# hmmscan :: search sequence(s) against a profile database
# HMMER 3.2.1 (June 2018); http://hmmer.org/
# Copyright (C) 2018 Howard Hughes Medical Institute.
# Freely distributed under the BSD open source license.
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
# query sequence file:             /oak/stanford/groups/akundaje/marinovg/genomes/Heterolobosea/Naegleria_gruberi_v1.0/GCA_000004985.1_V1.0_protein.faa
# target HMM database:             /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm
# output directed to file:         /oak/stanford/groups/akundaje/marinovg/genomes/Heterolobosea/Naegleria_gruberi_v1.0/GCA_000004985.1_V1.0_protein.PFam32-A
# per-seq hits tabular output:     /oak/stanford/groups/akundaje/marinovg/genomes/Heterolobosea/Naegleria_gruberi_v1.0/GCA_000004985.1_V1.0_protein.PFam32-A.tblout
# number of worker threads:        20
# - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Query:       EFC35186.1  [L=176]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.2e-27   94.1   0.6    8.1e-27   94.0   0.6    1.0  1  adh_short        short chain dehydrogenase
      1e-21   77.6   0.1    1.1e-21   77.4   0.1    1.0  1  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
    4.1e-08   33.4   0.1    4.4e-08   33.2   0.1    1.1  1  KR               KR domain
    2.2e-05   24.0   0.2    2.5e-05   23.9   0.2    1.3  1  Epimerase        NAD dependent epimerase/dehydratase family
    0.00025   20.3   0.1    0.00048   19.4   0.1    1.5  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
     0.0033   17.0   0.4     0.0053   16.3   0.4    1.3  1  Baculo_VP39      Baculovirus major capsid protein VP39
     0.0048   17.1   0.1     0.0059   16.9   0.1    1.3  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
  ------ inclusion threshold ------
      0.011   15.7   0.1      0.014   15.3   0.1    1.1  1  NAD_binding_10   NAD(P)H-binding
      0.013   14.7   0.3      0.022   13.9   0.1    1.5  2  RmlD_sub_bind    RmlD substrate binding domain
      0.014   14.7   1.2      0.018   14.4   1.2    1.1  1  LcrV             V antigen (LcrV) protein
      0.053   12.9   0.1      0.082   12.3   0.1    1.3  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.0   0.6     5e-30   8.1e-27       1     161 [.       6     174 ..       6     176 .] 0.85

  Alignments for each domain:
  == domain 1  score: 94.0 bits;  conditional E-value: 5e-30
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT.TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---S..S--SSGGGC CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee.gakalaiqvDvtdreevealvekavkklgkldvLvnNAGi..tgsgpfsel 96 
                 +++lvtGas+GIG ++ ++l+ ++ + +v++ s +  e ++k  ++  ++++++ q+Dv++ e++++lv+k +++  k+dvLvnNAG   +g  ++   
  EFC35186.1   6 NTILVTGASRGIGFELTQQLLDSNPNRIVYATSRSSSEDLVKLQEKVgAKRLIIEQLDVNNDESIDQLVQKLKDQNVKIDVLVNNAGSagNGADSVLTA 104
                 589**************************99999999888888777777889999*********************************44444445555 PP

                 SHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB.....-TTBHHHHHHHHHHHHHHH CS
   adh_short  97 seeewervievNltgvflltravlpamlkqssGrIvnvsSvagkvp.....vagvaaYsAsKaavagltr 161
                 + e + +++++N  +++ +++ ++++ l +++G + n+sS+ g  +     +a + +Y+ sK a+++ t+
  EFC35186.1 105 TRESVSALLQTNTLSPLIVAQKFYNNHLINENGLVANISSILGSISnvxshSAPYGSYGISKSALNMVTK 174
                 5666*********************9889**************65411111445667888*******997 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.4   0.1     7e-25   1.1e-21       1     153 [.      12     174 ..      12     176 .] 0.90

  Alignments for each domain:
  == domain 1  score: 77.4 bits;  conditional E-value: 7e-25
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGHHHHHHHHHHHTTSE..E.EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH-HHH CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneeakkrveelaeelgae..v.lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpfletsree 94 
                   Ga +gIG+++ ++l +   + ++   ++++ +++ +l+e++ga+  +  ++DV+++e++++lv++++++  k+D+lvnnag a +   ++l+++re+
    EFC35186.1  12 GASRGIGFELTQQLLDSNPNRIVYATSRSSSEDLVKLQEKVGAKrlIiEQLDVNNDESIDQLVQKLKDQNVKIDVLVNNAGSAGNGADSVLTATRES 108
                   999************999998888888888899*********9986469************************************999********* PP

                   HHHHHHHHTHHHHHHHHHHHH..HCTSCCEEEEEEEGGGTSB.STTTT....HHHHHHHHHHHHHH CS
  adh_short_C2  95 fdraldvnlyslfllakaalp..lmkeggsivnlssvgaerv.vpnyn....aygaaKaalealtr 153
                   +   l++n+ s + +a+ + +  l++e+g + n+ss+ ++++ v +++     yg++K al+ +t+
    EFC35186.1 109 VSALLQTNTLSPLIVAQKFYNnhLINENGLVANISSILGSISnVXSHSapygSYGISKSALNMVTK 174
                   ********************99999***********97776632222234459*********9998 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.2   0.1   2.7e-11   4.4e-08       2     109 ..       7     113 ..       6     157 .. 0.78

  Alignments for each domain:
  == domain 1  score: 33.2 bits;  conditional E-value: 2.7e-11
                 EEEEETTTSHHHHHHHHHHHHHHS-EEEE.E-SS..--HHHHHHHHHHHHTT-.EEEE----TT-HHHHHHHHHHHHHHSS---EEEE--------..- CS
          KR   2 tylitGGlGgLGlelarwlaekgarhlvl.lsRsaaadedskaliaelealga.evevvaaDvsdkdavealleeikaeeppikGvihaAgvlrdk..l 96 
                 t l+tG+  g+G el+++l+++  +++v+ +sRs     +s++l++  e+ ga +  + ++Dv + +++ +l++++k+++ +i   ++ Ag + ++   
  EFC35186.1   7 TILVTGASRGIGFELTQQLLDSNPNRIVYaTSRS-----SSEDLVKLQEKVGAkRLIIEQLDVNNDESIDQLVQKLKDQNVKIDVLVNNAGSAGNGadS 100
                 689******************9966666516666.....345455555556885788899******************************998754114 PP

                 TTT--HHHHHHHH CS
          KR  97 leemtaedleqvl 109
                 + + t e++ ++l
  EFC35186.1 101 VLTATRESVSALL 113
                 5566666666655 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.2   1.5e-08   2.5e-05       1      81 [.       8     101 ..       8     173 .. 0.83

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1.5e-08
                 EEEETTTSHHHHHHHHHHHHCT.SEEEEEES-STTTTCHHCHHC......EEEE--TT-HH....HHHHHHHHH.T-SEEEE--S.---HHHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekg.yevigldrlssasntarledl......elveldltdrs....alerlfkee.qpdavihlAa.vggvaass 81 
                 ilVtGa+  iG  l+++ll+ +  +++  +++ss++   +l+++       + +ld+ +++     +++l +++ ++d+ ++ A+  g+ a+s+
  EFC35186.1   8 ILVTGASRGIGFELTQQLLDSNpNRIVYATSRSSSEDLVKLQEKvgakrlIIEQLDVNNDEsidqLVQKLKDQNvKIDVLVNNAGsAGNGADSV 101
                 8*********************55577777777777777777667*****99*******99444444555556679*******99666665555 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.1   2.9e-07   0.00048       1      79 [.       8      80 ..       8      92 .. 0.79

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.9e-07
                     EEEETTTSHHHHHHHHHHHHHB-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT..T-S CS
  Polysacc_synt_2  1 vlvtGagGsiGselvrqilkkkpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrdkerlekaleelkvd 79
                     +lvtGa+  iG el++q+l+++p++i+   +   + + ++ +  e++ +k+l +e      dv++ e++++++++lk +
       EFC35186.1  8 ILVTGASRGIGFELTQQLLDSNPNRIVYATSRSSSEDLVKLQ--EKVGAKRLIIE----QLDVNNDESIDQLVQKLKDQ 80
                     89***********************99877666655555443..45666677455....67999999999999987655 PP

>> Baculo_VP39  Baculovirus major capsid protein VP39
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.4   3.3e-06    0.0053      87     176 ..      27     122 ..      15     152 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.3e-06
  Baculo_VP39  87 qkerdRvli.Psaknyeevfnvaslsaaeqlvfhli.YenkeavdkiCkdlkisefyte....kfsintqavialvsdvkksilglvspdilCsvv 176
                  +++ +R++   s+   e++ ++++   a++l++  +  +n+e++d++ ++lk+++   +    +  + ++  ++++  ++ s+  l+++++l   +
   EFC35186.1  27 DSNPNRIVYaTSRSSSEDLVKLQEKVGAKRLIIEQLdVNNDESIDQLVQKLKDQNVKIDvlvnNAGSAGNGADSVLTATRESVSALLQTNTLSPLI 122
                  34456766515677899****************88746999***********99986664333334444556778888888999999998887644 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.1   3.6e-06    0.0059       1      80 [.       8      94 ..       8     137 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 3.6e-06
                     EEEE--.SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHH..TTTCEEEEE--TTTHHHHHHHHHTTS.......SEEEE-SSGG CS
  Sacchrp_dh_NADP  1 vliiGa.GsvGqavaellarhfdvdaeitvadrskeklealaaka..lgvrfeaialdaenyeavLaallkeg.......dlvvnlsppi 80
                     +l+ Ga  ++G  +++ l+++++   +i+ a+   ++ + ++ ++    +r+++++ld++n+e+ +++l+++        d++vn +++ 
       EFC35186.1  8 ILVTGAsRGIGFELTQQLLDSNPN--RIVYATSRSSSEDLVKLQEkvGAKRLIIEQLDVNNDES-IDQLVQKLkdqnvkiDVLVNNAGSA 94
                     677788888999999999999998..88888766555444433334599***************.9999887777766666677666665 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.3   0.1   8.4e-06     0.014       1      87 [.      12     107 ..      12     127 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 8.4e-06
                     TTTSHHHHHHHHHHHHC-.T-EEEEEETT.HHHCHHHHCT...TTCEEEE--TT-CCHHHHHHT.......T-SEEEES---TCCHHHHHHHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellarg.ghevtalvRn.peklaeleae...eglevvegdvtdvedlaealk.......gadaVvsalggggkdeegaknivd 83 
                     GA+ ++G +l+++ll+++ +  v a  R+ +e+l +l+++   ++l + ++dv++ e++ + ++        +d+ v ++g+ g+   ga+++++
      EFC35186.1  12 GASRGIGFELTQQLLDSNpNRIVYATSRSsSEDLVKLQEKvgaKRLIIEQLDVNNDESIDQLVQklkdqnvKIDVLVNNAGSAGN---GADSVLT 103
                     9****************9877788888874456666664411156667789**99988888887666666666777777766665...3344443 PP

                     HHHH CS
  NAD_binding_10  84 aake 87 
                     a +e
      EFC35186.1 104 ATRE 107
                     3332 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   1.4e-05     0.022       2      59 ..       7      91 ..       6     116 .. 0.84
   2 ?   -2.8   0.0       1.6   2.6e+03     118     131 ..     155     168 ..     152     172 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.4e-05
                   EEEEESTTSHHHHHHHHHCTT..TSEEEEEE-TT....................T--TTSHHHHHHHH.....HHH--SEEEE-- CS
  RmlD_sub_bind  2 kilvtGanGqlGseLakqlae..eglevlaltre....................eldltdaeavaell.....keakpdvvvnaA 59
                   +ilvtGa+  +G eL++ql     +  v+a++r+                    +ld+++ e++++l+     +++k dv+vn A
     EFC35186.1  7 TILVTGASRGIGFELTQQLLDsnPNRIVYATSRSssedlvklqekvgakrliieQLDVNNDESIDQLVqklkdQNVKIDVLVNNA 91
                   69****************98722456688998889*********************************44444444555666655 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.6
                    ----SSHHHHHHHH CS
  RmlD_sub_bind 118 etsPlnvYGrtKla 131
                    + +P + YG +K a
     EFC35186.1 155 HSAPYGSYGISKSA 168
                    5689*****99975 PP

>> LcrV  V antigen (LcrV) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   1.2   1.1e-05     0.018      18     108 ..      56     149 ..      40     155 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.1e-05
                 XXXXXXXXXXEHHHHHHHHHHHHHTT-EEEE---TTT-SS----EEGCC-HHHHHHHHHHHS-HHHCHT-EE--HHH..HHH.HHHHHHHHHHS CS
        LcrV  18 kvrleqltgsgssvleelvqlvkdknidisikydprkdsevfanrvvtedkellkkllayflpedavlkgghldsql..kng.ikrlkefless 108
                 ++ +eql  +    +++lvq +kd+n++i +  +    +   a+ v+t  +e +  ll     +  ++    +++ l  +ng + ++ ++l s 
  EFC35186.1  56 RLIIEQLDVNNDESIDQLVQKLKDQNVKIDVLVNNAGSAGNGADSVLTATRESVSALLQTNTLSPLIVAQKFYNNHLinENGlVANISSILGSI 149
                 45689*************************999999888889***************9999999999999999999833345346777777665 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1     5e-05     0.082       1      75 [.       9      78 ..       9      92 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5e-05
                   EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevq 75
                   L+TG +  iG  l+++Ll+ + + ++    +s  + + + +l+++      ++l + + D+++ +s+++l+++ +
     EFC35186.1  9 LVTGASRGIGFELTQQLLDSNPNRIV--YATSRSSSEDLVKLQEKVG---AKRLIIEQLDVNNDESIDQLVQKLK 78
                   89****99***********9876544..3334444566777766553...579******************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       915  (0.0510346); expected 358.6 (0.02)
Passed bias filter:                      572  (0.0319036); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.57u 0.39s 00:00:00.96 Elapsed: 00:00:00.56
# Mc/sec: 948.82
//
Query:       EFC35187.1  [L=105]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       433  (0.0241508); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 609.00
//
Query:       EFC35188.1  [L=273]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-05   24.6   0.1      3e-05   24.1   0.1    1.2  1  DUF3074   Protein of unknown function (DUF3074)
     0.0035   16.8   0.0     0.0046   16.4   0.0    1.3  1  START     START domain


Domain annotation for each model (and alignments):
>> DUF3074  Protein of unknown function (DUF3074)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.1   3.4e-09     3e-05      56     167 ..     148     246 ..     106     263 .. 0.78

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 3.4e-09
     DUF3074  56 levvelsakfpgpltpRdFvvllltasseaeeeeseasekerefvvvslpidehpeaaerkglvrgqYeSvErirelpkeseesdeeenkveWimatrS 154
                  +++ ++a +p p+t+RdF v  + + ++ +++++e      +++++++p  +h+  +  k++vr++ + v ++++           + +v+ +++ + 
  EFC35188.1 148 NSIIYMEAPLPFPMTNRDFLVSKTIIPDKYDPSTGEYG----RYIMIQKPSYHHEFPPVAKSAVRANHTIVYIVEKK---------GNASVRYTCLETG 233
                 578899***************98888888888776653....59*******99999************999888433.........5678999999999 PP

     DUF3074 155 dagGsiPrflqek 167
                 d  G+iP  ++ +
  EFC35188.1 234 DMLGNIPAKITAQ 246
                 9999999988765 PP

>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   5.2e-07    0.0046      89     204 ..     139     264 ..      72     269 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 5.2e-07
                 CTT......EEEEEEEE--TT..-SS-EEEEEEEEEEE........TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEEXEE CS
       START  89 ssg......galqlyvaelvalsplspRdfvflRsire.......lgdgsyvivdrSvtseqnppesssvvRaellpSgilieplgnghskvtwvehvd 174
                 +++      +++ ++ a l +  p+ +Rdf++  +i          + g+y+       +  +pp  +s vRa++++  +++e++gn   + t +e  d
  EFC35188.1 139 DEQqgihypNSIIYMEAPLPF--PMTNRDFLVSKTIIPdkydpstGEYGRYIMIQKPSYHHEFPPVAKSAVRANHTI-VYIVEKKGNASVRYTCLETGD 234
                 444556666889999999999..*********9999888899887677888888877777888888******99988.7999999***9********** PP

                 XXSSXXHHHHHHHHHHHHHHHHHHHHHHTX CS
       START 175 lkgwlpkwllrslvksglaegaktwvatlq 204
                 + g++p  ++ ++ ks++  + k  ++ + 
  EFC35188.1 235 MLGNIPAKITAQFFKSTAKVMHKKIRKVCS 264
                 ******************999999888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (273 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       445  (0.0248201); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 1512.48
//
Query:       EFC35189.1  [L=178]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0042   15.8   1.4     0.0052   15.5   1.4    1.2  1  Tweety         Tweety
     0.0046   15.8   2.4     0.0062   15.3   2.4    1.2  1  DUF2207        Predicted membrane protein (DUF2207)
  ------ inclusion threshold ------
      0.058   13.7   0.2      0.058   13.7   0.2    2.2  2  Orf78          Orf78 (ac78)
       0.14   11.2   3.3       0.18   10.9   3.3    1.1  1  PHO4           Phosphate transporter family
          1    8.8  10.3       0.53    9.8   2.3    2.3  2  SieB           Super-infection exclusion protein B
        1.2    8.4   5.3        1.7    7.9   5.3    1.3  1  DUF3810        Protein of unknown function (DUF3810)
        3.1    8.1  17.0       0.51   10.6   2.4    2.5  2  Glycophorin_A  Glycophorin A
          9    5.9  10.3         18    4.9  10.3    1.5  1  Wzy_C          O-Antigen ligase
        9.1    6.5  13.5       0.27   11.5   1.5    2.4  2  Shisa          Wnt and FGF inhibitory regulator


Domain annotation for each model (and alignments):
>> Tweety  Tweety
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   1.4   2.6e-06    0.0052      18      70 ..      64     116 ..      48     163 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 2.6e-06
      Tweety  18 sllllasvaaallalsLlflllYlltlCCdrrkeeeeskkdsccvtwsvviat 70 
                 +l++ +++ ++++ +++ f+++Y++++ C+ r ++++++   + + + ++i  
  EFC35189.1  64 ALIMCGVIILIGILITITFVIFYIIRRLCCVRSSSTKKEYTNSNQMFIIIIYS 116
                 79999********************8766666555444442333333333322 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   2.4   3.1e-06    0.0062     338     427 ..      13     132 ..       3     168 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 3.1e-06
     DUF2207 338 eikkyakkskkkakkfkkalkkwksavkkkergyfdkkgkkklkklsalglgliilglilillallllvll............................ 408
                 +i++ +++++++++   +++++w ++++ k+ +  + ++     ++++ +++li++g+i+++++l++++++                            
  EFC35189.1  13 TIQQSSSNNNTNNNGDVSTWQDWFKNCDFKSVQSETPNNLDLCSWVRYSYFALIMCGVIILIGILITITFVifyiirrlccvrssstkkeytnsnqmfi 111
                 5677778878888888999999999999988888888888888888888888888888888888888887788999****************9988776 PP

     DUF2207 409 ..lvfllilllillliaiivl 427
                   ++ +li+l++++ ++ i++
  EFC35189.1 112 iiIYSFLIFLIVIGSLIGIIF 132
                 553333333333333222222 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.2   2.9e-05     0.058      27      91 ..      19      91 ..       8     104 .. 0.70
   2 ?    2.3   2.9      0.11   2.1e+02      54      80 ..     101     123 ..      92     138 .. 0.42

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.9e-05
       Orf78 27 dnddndkaenkkekksaaeknditekesn........aaekaqalnillisllavvcvlvllyviyYfvilre 91
                +n++++++ + ++ ++  ++ d+++ +s+        +  + +   +++ +++ ++ +l+ +  +++++i r 
  EFC35189.1 19 SNNNTNNNGDVSTWQDWFKNCDFKSVQSEtpnnldlcSWVRYSYFALIMCGVIILIGILITITFVIFYIIRRL 91
                3455555556666666777777777666677789888777888889999999999999999987788888886 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.11
       Orf78  54 snaaekaqalnillisllavvcvlvll 80 
                 ++  ++    n ++i ++  + +++++
  EFC35189.1 101 KE-YTNS---NQMFIIIIYSFLIFLIV 123
                 22.2222...33333333333333332 PP

>> PHO4  Phosphate transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   3.3   8.8e-05      0.18     113     211 ..      61     167 ..      41     175 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8.8e-05
        PHO4 113 kklvkivlswvlsPllggiiaallfllvkrlilvk..eklknalralpvlvlvtiailalsilfkgesk.....kddeeteklf.kflqvvsaalvsfa 203
                 + ++ i++++++   + + i +++f++++rl  v+  ++ k+  ++  ++++++ ++l+++i++          +++    +++ k++  +s ++  f 
  EFC35189.1  61 SYFALIMCGVIILIGILITITFVIFYIIRRLCCVRssSTKKEYTNSNQMFIIIIYSFLIFLIVIGSLIGiiftvSYGIGSGQVIsKTFETISKTFETFL 159
                 45667999999999999999***********88777655555566666677777777777777764432344445555555555588888999999999 PP

        PHO4 204 hGanDvan 211
                  +anD+++
  EFC35189.1 160 NSANDISK 167
                 99999887 PP

>> SieB  Super-infection exclusion protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   2.3   0.00027      0.53      28      71 ..      65     106 ..      53     113 .. 0.67
   2 ?    3.0   1.9     0.032        64      31      61 ..     124     154 ..     108     165 .. 0.59

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00027
        SieB  28 leeyglwiglvflisiayllaqvvskllaeikekikkkreqkkv 71 
                 l ++g +i +++li+i +++ +++ +l    ++  ++k+e+++ 
  EFC35189.1  65 LIMCGVIILIGILITITFVIFYIIRRLCCVRSS--STKKEYTNS 106
                 667888888888888888888888888844444..444444443 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.032
        SieB  31 yglwiglvflisiayllaqvvskllaeikek 61 
                  g  ig++f +s ++   qv+sk +++i++ 
  EFC35189.1 124 IGSLIGIIFTVSYGIGSGQVISKTFETISKT 154
                 3444555555555555555555555555555 PP

>> DUF3810  Protein of unknown function (DUF3810)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   5.3   0.00086       1.7      28      79 ..      75     137 ..      52     168 .. 0.48

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00086
     DUF3810  28 livllillvilylvlai...............klkkrkkkkkrllkvllrvllvllvvyflftllwg 79 
                  i+++i +vi+y    i               ++++ + +   ++++l+ ++++ +++ ++ft+ +g
  EFC35189.1  75 GILITITFVIFY----IirrlccvrssstkkeYTNSNQMFIIIIYSFLIFLIVIGSLIGIIFTVSYG 137
                 122233333333....245557665554322222222222222222444444444444444444444 PP

>> Glycophorin_A  Glycophorin A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   2.4   0.00026      0.51       8      90 ..      18      96 ..      11     109 .. 0.59
   2 ?    2.9   6.9     0.062   1.2e+02      62      82 ..     118     138 ..     100     153 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00026
                   XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXSSSSSSS-TTHHHHHHHHHHHHHHHH.HHHHHHHHTHSXXXX CS
  Glycophorin_A  8 ssttgdkskasvtastpsahevseltirtevaaeqeetgereqlvhdFselvitliifgvmAgvigti.llisYlirRliKKss 90
                   ss+ + +++ +v + +   ++    ++++e++ + +     + +   + +l + ++i+  + g++ ti ++i Y+irRl    s
     EFC35189.1 18 SSNNNTNNNGDVSTWQDWFKNCDFKSVQSETPNNLDL---CSWVRYSYFALIMCGVII--LIGILITItFVIFYIIRRLCCVRS 96
                   3333334445666666666666666666666665555...455555666677777764..4466555538899*****975443 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.062
                    HHHHHHHHHHHHHHHHHHHHH CS
  Glycophorin_A  62 liifgvmAgvigtillisYli 82 
                    li + v+ ++ig+i+ +sY i
     EFC35189.1 118 LIFLIVIGSLIGIIFTVSYGI 138
                    677889999**********99 PP

>> Wzy_C  O-Antigen ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9  10.3     0.009        18      19      74 ..      71     166 ..      60     170 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.009
       Wzy_C  19 iigllvalivlliifykrri.......................pfllllg.ilvgvilliilfv................lstnletlknitkafg 74 
                 ii +++++ + ++ify  r+                        + +l++ i++g +++ii+ v                +s+++et+ n  ++++
  EFC35189.1  71 IILIGILITITFVIFYIIRRlccvrssstkkeytnsnqmfiiiIYSFLIFlIVIGSLIGIIFTVsygigsgqvisktfetISKTFETFLNSANDIS 166
                 4555444444444554444456**************999999955555555777777777777788889999988888888888888888777766 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   1.5   0.00014      0.27      81     114 ..      43     100 ..       5     109 .. 0.59
   2 ?    2.6   4.2     0.073   1.4e+02      79     106 ..     104     131 ..      94     138 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00014
       Shisa  81 d........................iyvpvlivktifivfvivgvvvivcccgclkkk 114
                 +                         +v +li+  i i fvi  ++  +cc++    k
  EFC35189.1  43 SvqsetpnnldlcswvrysyfalimCGVIILIGILITITFVIFYIIRRLCCVRSSSTK 100
                 1222344556677778788888877889999999999999999888888887753322 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.073
       Shisa  79 pkdiyvpvlivktifivfvivgvvvivc 106
                  ++  ++++i+ + +i+++++g+++ ++
  EFC35189.1 104 TNSNQMFIIIIYSFLIFLIVIGSLIGII 131
                 22246899***************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1517  (0.0846115); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.62u 0.36s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 994.06
//
Query:       EFC35190.1  [L=215]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.3e-21   75.2   0.0    6.7e-21   74.8   0.0    1.1  1  Pkinase      Protein kinase domain
    2.7e-13   49.8   0.0    3.3e-13   49.5   0.0    1.1  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.8   0.0   7.5e-25   6.7e-21     117     260 ..       1     141 [.       1     144 [. 0.80

  Alignments for each domain:
  == domain 1  score: 74.8 bits;  conditional E-value: 7.5e-25
                 TTEE-SS-SGGGEEEET...TTE......EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCB..SHHHHHHHHHHHHHHHHHSS-STTTSSHHH CS
     Pkinase 117 kgiiHrDlKpeNiLide...kge......lKitDFGlakelessskltsfvgtseYlAPEvlkeney..skkvDvWslGvilyelltgkppfsgekgke 204
                 ++i H+D+Kp+NiL+++            +K++DF++  e + s+  +s  gt+ Yl+PEv  + +y   +k+Dv+s Gv+++ell+g+   +      
  EFC35190.1   1 MNISHCDIKPANILVNTieiA-GmnlfndVKLCDFDFIVEGDISN--SSHFGTRLYLPPEVKYDLGYseISKIDVYSFGVTMIELLCGHDFIK------ 90 
                 589*************64551.0466677********88777765..9*************98888844579********************9...... PP

                 HHHHHHHTHHHHHHHCTSHH...HH.HTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 205 kvekeldqlekilkilgetkeklpe.aseiseeakdllkkllkkdpkkRltaeellq 260
                 + ++++ qle      ++ + ++p   s++s+++ +++ +++++dpk+R+ ++ + +
  EFC35190.1  91 SLQSNVSQLE------ETLQHNFPClTSDMSKKLFEICVRCINQDPKERPPIKAIHE 141
                 3445666633......34445666415789********************9988765 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.5   0.0   3.7e-17   3.3e-13     123     259 .]       2     143 ..       1     143 [. 0.82

  Alignments for each domain:
  == domain 1  score: 49.5 bits;  conditional E-value: 3.7e-17
                  TEEEST-SGGGEEEEE........TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHH..HHHHHHHHHHHHHTTSSGTTTTS. CS
  Pkinase_Tyr 123 klvHrdlaarNvLlse........nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsks..DvWsfGvllwEiftlgespypgl. 209
                  ++ H d+   N+L+++         + vk++Df    +        +++++     +++pE+  +  +++ s  Dv+sfGv+++E+++ g++ +++l 
   EFC35190.1   2 NISHCDIKPANILVNTieiagmnlFNDVKLCDFDFIVEG-----DISNSSHFGTRLYLPPEVKYDLGYSEISkiDVYSFGVTMIELLC-GHDFIKSLq 93 
                  6779***********999999988889******998877.....4556666677779*********99975544*************9.999888886 PP

                  HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 210 kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                  +n + le   +++     ++++++l e+  +c ++dp+eRp +++++e+l
   EFC35190.1  94 SNVSQLEETLQHNFPCLTSDMSKKLFEICVRCINQDPKERPPIKAIHEQL 143
                  555555555444444555679**************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       487  (0.0271627); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 1292.64
//
Query:       EFC35191.1  [L=191]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1105  (0.061632); expected 358.6 (0.02)
Passed bias filter:                      255  (0.0142228); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.35s 00:00:00.91 Elapsed: 00:00:00.52
# Mc/sec: 1097.90
//
Query:       EFC35192.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.8e-17   60.9   0.0    9.2e-17   60.7   0.0    1.0  1  Ald_Xan_dh_C2    Molybdopterin-binding domain of aldehyde deh


Domain annotation for each model (and alignments):
>> Ald_Xan_dh_C2  Molybdopterin-binding domain of aldehyde dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.7   0.0   5.1e-21   9.2e-17     348     463 ..       2     120 ..       1     134 [. 0.82

  Alignments for each domain:
  == domain 1  score: 60.7 bits;  conditional E-value: 5.1e-21
                    HHHHHHT--GGGEEEE-SBTTSSS----S-TT-HHHHHHHHHHHHHHHHHHHHHHHHHHHCTS-CCCEEEETTEEEETEEEECHHHHHHHHHHTTS CS
  Ald_Xan_dh_C2 348 iaaeeLgvpledvrvvegdtdkvpngsgtaaSrstdlngnAvkkAaeklrerllkiaaellevspedleledgkvvvkeksvslaelaaaaylerv 443
                     ++++Lg+p e +++++++++ +pn + t +S++tdl  +A++ A++ l++rll+++++l++ + ++l+ ++ +   k  +++++el++ ay++r+
     EFC35192.1   2 CVSDKLGIPTELINISSANSNIIPNPISTCGSMGTDLFAGAALVACDILNQRLLPLKNKLFNENNNNLNENNLNENNKLSKKEWSELINYAYFNRI 97 
                    589*******************************************************999999999877433333334455************** PP

                    SEEEEEEE.........EEEETHCHC CS
  Ald_Xan_dh_C2 444 slsatgfykt......ldeetgkgpp 463
                     lsa g+yk+          ++++++
     EFC35192.1  98 CLSAIGYYKPkrttssN---NNNDNS 120
                    ********987764331...222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1700  (0.0948185); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.56
# Mc/sec: 873.43
//
Query:       EFC35193.1  [L=165]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-32  112.0   0.1    2.1e-32  111.6   0.1    1.1  1  Macro     Macro domain


Domain annotation for each model (and alignments):
>> Macro  Macro domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.6   0.1   1.2e-36   2.1e-32       1     117 [.      13     119 ..      13     120 .. 0.97

  Alignments for each domain:
  == domain 1  score: 111.6 bits;  conditional E-value: 1.2e-36
                 EEEEETTSS-CSHHHHHHHHHHHHHHHHHHHHHHHHHHS--TTSEEEEE-TTSSSSEEEEEESE-TTTSTSTTHHHHHHHHHHHHHHHHHHTT-SEEEE CS
       Macro   1 VnAaNsrllggggvagaihraagkalkeeckelekkqggcllGeavvtpaynlpakyvihtvgplftsskskeeeellakayknalelaeekgiksvaf 99 
                 VnAaN++llgggg++gaihraag +l+++  +l    +gc++G +++ p++ lpak++++tvgp+ +      ++++l++ay  +lel+ee +++++af
  EFC35193.1  13 VNAANESLLGGGGIDGAIHRAAGGKLRKYNAHL----HGCDTGCTKISPGFCLPAKFILNTVGPVGE------NPQKLTSAYTTCLELVEEYQLRTIAF 101
                 9********************************....78**************************95......9************************* PP

                 E-TTSSTTSBTHHHHHHH CS
       Macro 100 PaistGifgvpweeaarv 117
                 + istGifg+p+++a+ +
  EFC35193.1 102 CGISTGIFGYPLDKATII 119
                 **************9866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       451  (0.0251548); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 948.00
//
Query:       EFC35194.1  [L=340]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-19   69.1   0.7    0.00017   21.4   0.1    5.9  5  NHL             NHL repeat
    2.2e-14   53.5  43.9    3.8e-05   24.0  12.2    3.4  3  EGF_2           EGF-like domain
    8.7e-08   32.3  23.0    0.00045   20.5   2.7    3.5  3  EGF             EGF-like domain
    0.00024   21.6  35.2     0.0062   17.1   5.9    4.0  3  hEGF            Human growth factor-like EGF
  ------ inclusion threshold ------
       0.14   12.9   0.1       0.55   10.9   0.0    1.9  2  potato_inhibit  Potato inhibitor I family


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.1   1.4e-05     0.052       6      27 ..      31      51 ..      26      52 .. 0.86
   2 !   21.4   0.1   4.8e-08   0.00017       1      26 [.      81     106 ..      81     106 .. 0.96
   3 ?   -0.5   0.0      0.44   1.6e+03       5      16 ..     120     131 ..     120     133 .. 0.84
   4 !   11.5   0.0   6.7e-05      0.24       2      26 ..     137     161 ..     136     161 .. 0.92
   5 !   14.9   0.0   5.5e-06      0.02       1      27 [.     310     336 ..     310     337 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.4e-05
                EEEEETTTEEEEEECCCTEEEE CS
         NHL  6 GvavdsnGdiyVaDsenhrvqv 27
                Gv+v+ n+++y++Ds+n+ v++
  EFC35194.1 31 GVRVV-NDEVYISDSNNFKVRK 51
                99995.************9986 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 4.8e-08
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P++va +snG+ ++aD+ n+rv+
  EFC35194.1  81 LNHPTDVAFLSNGEMLIADTDNNRVR 106
                 79**********************96 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.44
                 EEEEEETTTEEE CS
         NHL   5 hGvavdsnGdiy 16 
                 +G+a +s+G+i 
  EFC35194.1 120 NGTASFSDGRIA 131
                 589999****96 PP

  == domain 4  score: 11.5 bits;  conditional E-value: 6.7e-05
                 SSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvq 26 
                 + P+G+ v+s+ +iy+aD +n r++
  EFC35194.1 137 SLPTGILVVSDVEIYIADAKNGRIR 161
                 679********************95 PP

  == domain 5  score: 14.9 bits;  conditional E-value: 5.5e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f +P+ +a +snGd++V+D   h +++
  EFC35194.1 310 FVDPQKIARLSNGDLIVSDATGHAIKK 336
                 678****************88888765 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   8.4   5.3e-08   0.00019       4      32 .]     176     204 ..     173     204 .. 0.87
   2 !   24.0  12.2   1.1e-08   3.8e-05       4      32 .]     215     243 ..     209     243 .. 0.89
   3 !   19.9   7.3     2e-07    0.0007       5      32 .]     256     282 ..     251     282 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 5.3e-08
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s +++C+g+G C ++   C+C++g++G++C
  EFC35194.1 176 SeNSACNGNGLCFDTD-TCVCQQGWSGANC 204
                 45799*******6566.8************ PP

  == domain 2  score: 24.0 bits;  conditional E-value: 1.1e-08
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ghG+Cvn++  C+C++g++ ++C
  EFC35194.1 215 NdNSVCSGHGSCVNTE-TCVCKQGWYSANC 243
                 3699********9999.9***********9 PP

  == domain 3  score: 19.9 bits;  conditional E-value: 2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ CgghG+C ++  qC+C   ++G +C
  EFC35194.1 256 SSVCGGHGSCLSLD-QCSCTGLWTGSNC 282
                 789*******9999.************* PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   2.7   1.3e-07   0.00045       5      32 .]     178     203 ..     174     203 .. 0.86
   2 !   18.6   2.9   4.8e-07    0.0017       4      28 ..     216     238 ..     213     242 .. 0.85
   3 ?    4.5   2.3     0.012        44       5      31 ..     255     280 ..     252     281 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.3e-07
                 T..STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGkr 32 
                 +  C+++G C+dt     tC C++G++G++
  EFC35194.1 178 NsaCNGNGLCFDTD----TCVCQQGWSGAN 203
                 446*******8888....**********85 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 4.8e-07
                 TT..STTT-EEEEETTTEEEEEECTTE CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGy 28 
                 ++  Cs++G Cv+t+    tC C++G+
  EFC35194.1 216 DNsvCSGHGSCVNTE----TCVCKQGW 238
                 3468***********....*******7 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.012
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                     C ++G C+++     +C C+  +tG+
  EFC35194.1 255 DssvCGGHGSCLSLD----QCSCTGLWTGS 280
                 444599*****9999....****9778876 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   7.5   6.5e-06     0.023       1      22 []     181     199 ..     181     199 .. 0.93
   2 !   17.1   5.9   1.7e-06    0.0062       1      22 []     220     238 ..     220     238 .. 0.97
   3 ?    0.5   5.9       0.3   1.1e+03       1      18 [.     259     273 ..     259     274 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 6.5e-06
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G C+   +  +C+C +G+
  EFC35194.1 181 CNGNGLCF---DTDTCVCQQGW 199
                 ********...667******** PP

  == domain 2  score: 17.1 bits;  conditional E-value: 1.7e-06
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G+C+   +  +C+C++G+
  EFC35194.1 220 CSGHGSCV---NTETCVCKQGW 238
                 ********...889******** PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.3
                 --TT-EES..-SS..-EE- CS
        hEGF   1 CnngGtCidgvgg.ykCiC 18 
                 C ++G+C     +  +C C
  EFC35194.1 259 CGGHGSCL----SlDQCSC 273
                 9*******....5579999 PP

>> potato_inhibit  Potato inhibitor I family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00015      0.55      28      57 ..      86     115 ..      78     118 .. 0.81
   2 ?   -2.3   0.0       2.1   7.6e+03      31      53 ..     144     166 ..     141     170 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00015
  potato_inhibit  28 vvevvpegspvtadfrcnRVrvfvdengiV 57 
                     +v ++ +g++++ad + nRVr +  +  iV
      EFC35194.1  86 DVAFLSNGEMLIADTDNNRVRMVLTNGTIV 115
                     4569*****************988754554 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2.1
  potato_inhibit  31 vvpegspvtadfrcnRVrvfvde 53 
                     vv + ++++ad +  R+r++  +
      EFC35194.1 144 VVSDVEIYIADAKNGRIRLLSTK 166
                     55666778889999999997654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       581  (0.0324056); expected 358.6 (0.02)
Passed bias filter:                      227  (0.0126611); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 2149.00
//
Query:       EFC35195.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-06   27.1   0.0      0.045   13.8   0.0    2.5  2  NHL       NHL repeat
      0.002   17.7   0.0        0.1   12.2   0.0    2.0  2  SGL       SMP-30/Gluconolactonase/LRE-like region


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0     5e-06     0.045       1      27 [.      38      64 ..      38      65 .. 0.94
   2 !   11.0   0.0     4e-05      0.36       8      27 ..     101     120 ..      94     121 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 5e-06
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +++P+Gv v +n+++y aD  nhrv++
  EFC35195.1 38 LYSPEGVFVAPNDEVYMADIQNHRVRK 64
                689**********************97 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 4e-05
                 EEETTTEEEEEECCCTEEEE CS
         NHL   8 avdsnGdiyVaDsenhrvqv 27 
                  v+ ++++y++D++n r+++
  EFC35195.1 101 FVSLTNEVYISDFGNYRIRK 120
                 555589************87 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   1.1e-05       0.1     169     218 ..      26      73 ..      11      83 .. 0.74
   2 !    4.0   0.0    0.0036        32     184     222 ..      95     133 ..      78     139 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.1e-05
         SGL 169 klsnrrvfadlkkge....gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 k+ n+++       +      p G++v  +++v++A +++++v+++ +dG++++
  EFC35195.1  26 KMMNKKLA------TeamlYSPEGVFVAPNDEVYMADIQNHRVRKILKDGTIVT 73 
                 23344433......2333355*****************************9886 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.0036
         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdpdGklieeikl 222
                 + p G++v  +++v++  +g+ +++++  +G++++ + +
  EFC35195.1  95 SHPCGVFVSLTNEVYISDFGNYRIRKILRNGNIVTIVGT 133
                 458899**************************9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       866  (0.0483016); expected 358.6 (0.02)
Passed bias filter:                      661  (0.0368676); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.25s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1094.56
//
Query:       EFC35196.1  [L=301]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       527  (0.0293937); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 2028.34
//
Query:       EFC35197.1  [L=214]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0094   15.7   0.0      0.012   15.3   0.0    1.1  1  Yip1       Yip1 domain
  ------ inclusion threshold ------
      0.026   14.4   2.4      0.046   13.6   2.4    1.5  1  TMEM154    TMEM154 protein family
      0.054   13.8   0.1       0.11   12.9   0.1    1.5  1  Orf78      Orf78 (ac78)
      0.083   12.8   0.1       0.12   12.3   0.1    1.2  1  Med12-PQL  Eukaryotic Mediator 12 catenin-binding domain


Domain annotation for each model (and alignments):
>> Yip1  Yip1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   2.8e-06     0.012      53     100 ..     148     202 ..     119     207 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 2.8e-06
        Yip1  53 evqgltlssllgaiiggylglllgllllalllhliakllg.......gkgsfkqt 100
                  v + ++s +l+++++++++++l++ll+a+++++++k lg       +++s++qt
  EFC35197.1 148 IVKKPATSNPLMWLLMLLVLIPLTALLIAVIIWFVVKKLGkdknntrNSHSYMQT 202
                 45667889999****************************9777777666667776 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   2.4     1e-05     0.046       8      93 ..      97     194 ..      81     211 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1e-05
     TMEM154   8 gdtaletatleeesadatsaasteseslkqeeakeslssaelsnesdqlel.................vlmiiiPlvllillllvviiliqkkkrkrsK 89 
                 g+ +let+ +   s++   +a  e ++l  ++a+ + +s+e++ +s++ +                  +l+++iPl +l++ +++  +   +kk  + K
  EFC35197.1  97 GSASLETDCAI--SIKNNQIATCECSTLGYNLAILEYKSIETASTSSSSNSniivkkpatsnplmwllMLLVLIPLTALLIAVIIWFV---VKKLGKDK 190
                 55555555443..344444555555666666666666666666666555545568888888899998899999999877654444333...44555555 PP

     TMEM154  90 ddek 93 
                 ++++
  EFC35197.1 191 NNTR 194
                 5543 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   2.4e-05      0.11      48      99 ..     139     196 ..     124     200 .. 0.49

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.4e-05
       Orf78  48 ditekesn...aaekaqalnillisllavvcvl.vllyviyYfvilrerqkssv..ke 99 
                  +++++sn   ++ ++++  + l++ll+++ +  +l+ vi++fv+ +  + +++  ++
  EFC35197.1 139 TSSSSNSNiivKKPATSNPLMWLLMLLVLIPLTaLLIAVIIWFVVKKLGKDKNNtrNS 196
                 2223333344322333333344444445555551455789999999885554442234 PP

>> Med12-PQL  Eukaryotic Mediator 12 catenin-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   2.7e-05      0.12      69     150 ..      10      92 ..       1     100 [. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.7e-05
   Med12-PQL  69 imgldksykmkvykpqpsipqgqllrqqlqakllnqgmlgqqqlrqmeplssygslql..apqGYTsYgshmglQqhpsqaggl 150
                 ++++   ++ + + +  si+    +r ++q+ + ++ ++ +q+ + ++ +s + slql  +pq Y  Y  ++ + q  sqa  +
  EFC35197.1  10 MVNITLPLNISTFLKTNSIKSPIKYRWNIQKNT-DTIAILKQPGKMISINSVVNSLQLdpSPQSYSKYLFDIEMKQYDSQATYV 92 
                 5555556667778888889888999999*9999.5555555599999**********6679*******************9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       999  (0.0557198); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1377.36
//
Query:       EFC35198.1  [L=227]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.25   11.3   4.7       0.97    9.5   4.7    2.0  1  TMF_DNA_bd  TATA element modulatory factor 1 DNA binding


Domain annotation for each model (and alignments):
>> TMF_DNA_bd  TATA element modulatory factor 1 DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   4.7   5.4e-05      0.97       2      43 ..      22      63 ..      21      68 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 5.4e-05
  TMF_DNA_bd  2 slekklkeKDeqIaqLmeEGekLskkelklnntikkLrkknk 43
                +l+k ++eKD +I+  ++E e ++ k    +++++k   +++
  EFC35198.1 22 ELTKIVEEKDIIIERFRKETESYKEKLESYRKSMSKYETQIQ 63
                78999**************************99999887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2248  (0.125383); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1358.89
//
Query:       EFC35199.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       840  (0.0468515); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1292.62
//
Query:       EFC35200.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0016   18.3   3.0       0.89    9.8   0.1    3.1  3  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
      0.024   15.3   2.6         16    6.4   0.0    3.6  4  LRR_2     Leucine Rich Repeat
        1.8    9.1   7.2        8.9    6.9   0.1    3.8  4  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0   0.00059       3.6       4      20 ..      76      92 ..      75      94 .. 0.90
   2 ?   -2.8   0.4       1.6   9.5e+03       3      10 ..     167     174 ..     166     174 .. 0.80
   3 !    9.8   0.1   0.00015      0.89       4      16 ..     246     258 ..     244     260 .. 0.90

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00059
       LRR_6  4 hLteLdLsgNdIgDeGa 20
                 L+++ ++ N+++D+Ga
  EFC35200.1 76 FLETVVITRNNFNDDGA 92
                6999************9 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.6
       LRR_6   3 thLteLdL 10 
                 ++L++L L
  EFC35200.1 167 SNLKTLKL 174
                 68999976 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00015
       LRR_6   4 hLteLdLsgNdIg 16 
                 hL++L+L gN+I 
  EFC35200.1 246 HLKYLHLEGNNIK 258
                 9***********7 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.8   1.7e+04       5      14 ..      29      38 ..      28      39 .. 0.79
   2 ?   -1.6   0.0      0.88   5.2e+03       7      13 ..      77      87 ..      76      92 .. 0.60
   3 ?    6.0   1.1    0.0034        20       1      15 [.     168     182 ..     168     186 .. 0.87
   4 ?    6.4   0.0    0.0026        16       2      17 ..     247     262 ..     246     263 .] 0.91

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.8
       LRR_2  5 LhLdsVrfsd 14
                L++ s+ f+d
  EFC35200.1 29 LYILSFAFPD 38
                8999999976 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.88
       LRR_2  7 LdsVrf....s 13
                L++V++    +
  EFC35200.1 77 LETVVItrnnF 87
                88888843333 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0034
       LRR_2   1 sLKtLhLdsVrfsde 15 
                 +LKtL L++V  +++
  EFC35200.1 168 NLKTLKLHRVHLFSD 182
                 6*********99877 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.0026
       LRR_2   2 LKtLhLdsVrfsdeds 17 
                 LK LhL+ + ++++ s
  EFC35200.1 247 LKYLHLEGNNIKGGQS 262
                 9**********99987 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.35   2.1e+03      22      36 ..      74      88 ..      60      90 .. 0.75
   2 ?   -3.1   0.0       2.1   1.3e+04      23      29 ..     145     151 ..     132     153 .. 0.56
   3 ?    2.9   1.1     0.028   1.6e+02      22      39 ..     166     183 ..     160     201 .. 0.71
   4 ?    6.9   0.1    0.0015       8.9      22      34 ..     244     256 ..     225     260 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.35
                -TT--EEE-.-S--- CS
       LRR_4 22 lpnLkeLdLsgNnli 36
                 p L+++ +++Nn+ 
  EFC35200.1 74 YPFLETVVITRNNFN 88
                677999999999876 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 2.1
                 TT--EEE CS
       LRR_4  23 pnLkeLd 29 
                 pn++ L+
  EFC35200.1 145 PNMERLS 151
                 5666655 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.028
                 -TT--EEE-.-S-----G CS
       LRR_4  22 lpnLkeLdLsgNnlitdl 39 
                 l nLk+L L++  l +dl
  EFC35200.1 166 LSNLKTLKLHRVHLFSDL 183
                 888888888665444444 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0015
                 -TT--EEE-.-S- CS
       LRR_4  22 lpnLkeLdLsgNn 34 
                 l +Lk+L+L gNn
  EFC35200.1 244 LEHLKYLHLEGNN 256
                 7788888888874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       379  (0.0211389); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1666.32
//
Query:       EFC35201.1  [L=144]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.6e-27   94.1   0.0    6.8e-27   93.6   0.0    1.2  1  Orn_DAP_Arg_deC  Pyridoxal-dependent decarboxylase, C-termina


Domain annotation for each model (and alignments):
>> Orn_DAP_Arg_deC  Pyridoxal-dependent decarboxylase, C-terminal sheet domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.6   0.0   3.8e-31   6.8e-27       6      98 .]      11      98 ..       7      98 .. 0.90

  Alignments for each domain:
  == domain 1  score: 93.6 bits;  conditional E-value: 3.8e-31
                     GGEEEEEEEEEEEEETCEEEEEES--TTTS-HHHHCTT-S-E.ESBTT-SCEEC.EEEEEEEE-SSSSTT-EEEEEEEEEE--TT-EEEESS-S CS
                     xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Orn_DAP_Arg_deC  6 eagvLvtrViavkesekkkfvivdaGmndllrpalygsfhei.pvkeeeaekeeeeeeevdvvGptCesgDvlakdrelpelevGdllafedaG 98
                     +ag+L+t+V + k+ e+k+f++vda+mndl+rpa+y+++h + +vke+     + + + +dvvGp+CesgD+la++rel ++++Gdlla+++aG
       EFC35201.1 11 NAGLLLTEVQYLKHGEEKNFAVVDAAMNDLMRPAMYEAWHGVqTVKEN-----AGQPRIYDVVGPVCESGDWLARSREL-AIHEGDLLALMSAG 98
                     8**************999************************666533.....334456********************.9***********99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (144 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       313  (0.0174578); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 913.19
//
Query:       EFC35202.1  [L=323]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00017   21.9  27.6    0.00022   21.5   5.1    2.8  3  EGF_2     EGF-like domain
  ------ inclusion threshold ------
      0.043   14.1   2.7      0.043   14.1   2.7    3.7  4  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   5.1   2.4e-08   0.00022       6      32 .]      49      74 ..      44      74 .. 0.90
   2 !   12.5   7.3   1.7e-05      0.15       6      32 .]      89     118 ..      85     118 .. 0.76
   3 ?   -3.1   0.7       1.2   1.1e+04      17      21 ..     129     134 ..     127     135 .. 0.45

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 2.4e-08
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                + C+ghG+Cv++   C+C++g++  +C
  EFC35202.1 49 NVCSGHGICVDTD-ICSCFPGHTNSQC 74
                68*******9777.9*********999 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 1.7e-05
       EGF_2   6 eiCgghGtCvnqcGqCdC..dsgyq..GktC 32 
                 + C+ghGtC+ ++  C C  ++g    G++C
  EFC35202.1  89 NVCSGHGTCIGPN-MCNCtiQDGVVygGDSC 118
                 67********888.9***8866544456666 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.2
       EGF_2  17 qcGq.C 21 
                 +cG+ C
  EFC35202.1 129 SCGNdC 134
                 344334 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.6      0.77   6.9e+03      12      23 ..      30      40 ..      28      40 .. 0.72
   2 ?   14.1   2.7   4.8e-06     0.043       4      29 ..      49      70 ..      45      73 .. 0.87
   3 ?    5.0   4.4    0.0034        30       5      24 ..      88     105 ..      85     115 .. 0.75
   4 ?   -2.0   0.6      0.53   4.7e+03       4      15 ..     128     137 ..     126     141 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.77
                EEEETTTEEEEE CS
         EGF 12 CvdtgrggytCi 23
                C+    ++++C+
  EFC35202.1 30 CLVDA-EDFSCF 40
                66666.899996 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 4.8e-06
                TTSTTT-EEEEETTTEEEEEECTTEE CS
         EGF  4 npCsngGtCvdtgrggytCiCpeGyt 29
                n Cs++G+Cvdt     +C C +G t
  EFC35202.1 49 NVCSGHGICVDTD----ICSCFPGHT 70
                44***********....******977 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0034
                 T..STTT-EEEEETTTEEEEEE CS
         EGF   5 p..CsngGtCvdtgrggytCiC 24 
                 p  Cs++GtC+    g   C C
  EFC35202.1  88 PnvCSGHGTCI----GPNMCNC 105
                 445*******4....4446777 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 0.53
                 TTSTTT-EEEEE CS
         EGF   4 npCsngGtCvdt 15 
                 n C n+  C +t
  EFC35202.1 128 NSCGND--CKST 137
                 449999..9665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.23s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 2315.42
//
Query:       EFC35203.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1399  (0.07803); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 1112.85
//
Query:       EFC35204.1  [L=227]
Description: glutathione S-transferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-10   39.8   0.2    1.4e-09   38.1   0.1    1.8  2  GST_C          Glutathione S-transferase, C-terminal domain
    5.9e-07   29.6   0.6    1.1e-06   28.7   0.6    1.4  1  GST_C_3        Glutathione S-transferase, C-terminal domain
    2.8e-05   24.0   0.0    5.3e-05   23.2   0.0    1.4  1  GST_C_2        Glutathione S-transferase, C-terminal domain
    8.4e-05   22.8   0.1    0.00016   21.9   0.1    1.4  1  GST_N_2        Glutathione S-transferase, N-terminal domain
    0.00023   21.5   0.0    0.00045   20.6   0.0    1.5  1  GST_N_3        Glutathione S-transferase, N-terminal domain
  ------ inclusion threshold ------
      0.077   13.3   0.5       0.55   10.6   0.5    2.2  1  GST_N          Glutathione S-transferase, N-terminal domain
       0.22   11.8   3.5       0.13   12.6   0.5    2.1  2  Thioredoxin_8  Thioredoxin-like


Domain annotation for each model (and alignments):
>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.84   2.1e+03      54      91 ..      78     116 ..      77     117 .. 0.76
   2 !   38.1   0.1   5.3e-13   1.4e-09       8      92 ..     126     210 ..     120     211 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.84
                 CHHHHHHHHHHHHHHHHTTTTT.TTTSHHHHHHHHHHHT CS
       GST_C  54 tlADialvpilnwlqrlglafg.qekfpnlkawlerima 91 
                 tlA ++++  l ++ +l+++    +k  + ++w++ i++
  EFC35204.1  78 TLAICYFLSELFINGKLEPNRNnLQKRAKFHQWMSLICN 116
                 666677778788888888877777999999999987776 PP

  == domain 2  score: 38.1 bits;  conditional E-value: 5.3e-13
                 HHHHHHSTTHHHHHHHHHHHHHHHHHHHHHHHHHHH.TSSSSSTT.SSCHHHHHHHHHHHHHHHHTTTTTTTTSHHHHHHHHHHHTS CS
       GST_C   8 illlfyvkaeekkeelvdealekvaevlsaleeelk.kqdylvGd.kltlADialvpilnwlqrlglafgqekfpnlkawlerimar 92 
                 +   +yvk++e++e l++e +e+++e ++++e+elk ++ y+ G+ ++++ Di+l+ +++w +  +l++   + p l ++leri++r
  EFC35204.1 126 YYSHRYVKSIEQEELLKKETEERMFEKFKIFENELKdGREYILGNnEYSIIDIYLFVVATWTRNMNLKAR--DLPFLGKYLERIFNR 210
                 556789*******************************9999988537**********************5..*************98 PP

>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.6   4.4e-10   1.1e-06       2      98 ..     121     219 ..     120     220 .. 0.84

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 4.4e-10
                 HHHHHHHCCCC.SHCHHHHHHHHHHHHHHHCHHHHHHHHHHCHGTSSSSTT.S--HHHHHHHHHHHHHHHHTCC.CC-HHHHHHHHHHHTSHHHHHHHC CS
     GST_C_3   2 Dlhhpiaklly.dqkeeaekkkefleerlpkflkyfekvlkkkgggylvgd.klTyADlalfqvldgleeaeal.kkfpklkalyervearpkikaYle 97 
                 D  h +++  y +  e++e  k+  eer+ + +k fe+ lk +g +y++g+ + ++ D+ lf v   +++++ + ++ p l ++ er+ +r+ + + ++
  EFC35204.1 121 DSYHYYYSHRYvKSIEQEELLKKETEERMFEKFKIFENELK-DGREYILGNnEYSIIDIYLFVVATWTRNMNLKaRDLPFLGKYLERIFNRKIVNEIVK 218
                 5566677777754444449**********************.8999***7659******************44459**************998887666 PP

                 T CS
     GST_C_3  98 s 98 
                 s
  EFC35204.1 219 S 219
                 5 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.0   2.1e-08   5.3e-05       5      67 ..     143     204 ..     138     206 .. 0.82

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 2.1e-08
                 CHHHHHCCHCHHHCTTT---SS..CTTC.S--HHHHHHHHHHHHHHHHHHS----TT-HHHHHHH CS
     GST_C_2   5 eraleqldaaldaleahLadsp.flfGd.qptlaDialapflvrlraagpgfdireaypnlraWl 67 
                 ++ +e+++++++ +e++L+d++ +++G+ + ++ Di l+++  ++r    +     ++p+l ++l
  EFC35204.1 143 KETEERMFEKFKIFENELKDGReYILGNnEYSIIDIYLFVVATWTRNMNLKA---RDLPFLGKYL 204
                 566899***************************************9886332...3455555555 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.1   6.1e-08   0.00016      30      69 ..      32      87 ..      16      88 .. 0.76

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 6.1e-08
                TTSHHHHHHHHCTTTSSSEEE-...........CTTE.......EEESHHHHHHHHHH CS
     GST_N_2 30 gfekseefprlnprgtVPvLwd...........kdgq.......vineSseIlrylet 69
                 + kse +++lnp+g VP+L++           +  +       vi+e+++I+ +l +
  EFC35204.1 32 KDLKSEKYLKLNPQGIVPTLVIeyinnnnnninD--NnneptiiVIYETLAICYFLSE 87
                3346899***************888777766652..04578899*********99976 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   1.8e-07   0.00045      24      71 ..      22      89 ..       4      93 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.8e-07
                EEEE---...TTTTHHHHHHH-TT--SSEE......ETTS-..............EEESHHHHHHHHHHHH CS
     GST_N_3 24 vevvevt...pgehdeellaknplgkvPvL......eddge..............altdSlaIidyLeely 71
                ve+ +++   ++ ++e +l+ np+g vP+L                         +++++laI+ +L el+
  EFC35204.1 22 VEIINLSrdvKDLKSEKYLKLNPQGIVPTLvieyinN---NnnnindnnneptiiVIYETLAICYFLSELF 89
                55666654445667****************8874430...23566677789****************9886 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.5   0.00021      0.55      27      61 ..      21      65 ..      19      87 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00021
                EEEEEEECSTTTCGGCHHHHHHCTTS-SSEEEET..........T CS
       GST_N 27 eyevvpldfeageekspellklnplgkvPaLedn..........g 61
                ++e+++l ++ +  ks+++lklnp g vP+L+++          +
  EFC35204.1 21 QVEIINLSRDVKDLKSEKYLKLNPQGIVPTLVIEyinnnnnninD 65
                6899999999999999***************99866655555550 PP

>> Thioredoxin_8  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.5   5.1e-05      0.13      32      74 ..      17      63 ..       6      78 .. 0.64
   2 ?   -0.9   0.1      0.82   2.1e+03      52      52 ..     143     143 ..      98     190 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 5.1e-05
                   H.TTSEEEEEEE-SS-HHHHHHHGGGS-T...TSEE.EE-TT-HHHH CS
  Thioredoxin_8 32 k.kkkveivyvsldkkeeefekylkknkk...pwlsvpfddkkrnkl 74
                   +  ++vei+ +s d k  + ekylk n++   p l +++ + ++n +
     EFC35204.1 17 QnIHQVEIINLSRDVKDLKSEKYLKLNPQgivPTLVIEYINNNNNNI 63
                   2479***********************33223444444444443333 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.82
                    H CS
  Thioredoxin_8  52 k 52 
                    k
     EFC35204.1 143 K 143
                    3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       908  (0.0506442); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1505.46
//
Query:       EFC35205.1  [L=289]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      1e-12   48.2 100.9    0.00042   20.6  10.2    7.8  8  EGF_2        EGF-like domain
    7.2e-06   26.0  78.9       0.12   12.5  15.6    5.8  5  Laminin_EGF  Laminin EGF domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   4.7   4.9e-06     0.044      14      32 .]       2      19 ..       1      19 [. 0.90
   2 !   20.6  10.2   4.7e-08   0.00042       5      32 .]      32      58 ..      24      58 .. 0.85
   3 !   13.7   4.9     7e-06     0.063       5      32 .]      71     102 ..      67     102 .. 0.84
   4 ?   -2.4   0.1      0.75   6.8e+03      23      32 .]     105     114 ..     104     114 .. 0.78
   5 !   15.7  15.4   1.6e-06     0.014       1      32 []     123     152 ..     123     152 .. 0.90
   6 ?    1.5   3.3     0.045     4e+02      23      32 .]     155     164 ..     154     164 .. 0.96
   7 !   16.3   8.0     1e-06    0.0092       1      32 []     168     204 ..     168     204 .. 0.75
   8 !    4.5   6.0    0.0053        48      22      32 .]     206     216 ..     203     216 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 4.9e-06
       EGF_2 14 CvnqcGqCdCdsgyqGktC 32
                C  ++G+CdC+ g++G++C
  EFC35205.1  2 CL-STGVCDCPYGWTGDSC 19
                75.589************* PP

  == domain 2  score: 20.6 bits;  conditional E-value: 4.7e-08
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyqGktC 32
                 + Cgg G+C++   +C+C++gy+G +C
  EFC35205.1 32 ASVCGGKGSCIDID-RCQCNAGYSGTKC 58
                789*******8666.9************ PP

  == domain 3  score: 13.7 bits;  conditional E-value: 7e-06
       EGF_2   5 deiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                  + C+ hG+C ++  +C+C     +  + G +C
  EFC35205.1  71 TTVCSSHGVCLSPD-KCQCaltleKGFWNGQQC 102
                 568********999.****99997777779988 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 0.75
       EGF_2  23 CdsgyqGktC 32 
                 C+  y+G +C
  EFC35205.1 105 CKLPYTGVKC 114
                 7777999999 PP

  == domain 5  score: 15.7 bits;  conditional E-value: 1.6e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C++ d +C ghG+C++  G C+C  +++G +C
  EFC35205.1 123 CQD-DVTCFGHGKCNS-KGSCVCTGNFYGTNC 152
                 887.799*******94.469************ PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.045
       EGF_2  23 CdsgyqGktC 32 
                 C++gy+G +C
  EFC35205.1 155 CKTGYYGYDC 164
                 *********9 PP

  == domain 7  score: 16.3 bits;  conditional E-value: 1e-06
       EGF_2   1 CsasdeiCgghGtCvnqc.GqCdC.....dsgyqGktC 32 
                 C + + +C+g+G+C++   G+C C     +  ++G +C
  EFC35205.1 168 CDP-KITCSGNGYCDSILgGVCTCnnnlsNGYFTGTNC 204
                 544.579*******655538****98885566669998 PP

  == domain 8  score: 4.5 bits;  conditional E-value: 0.0053
       EGF_2  22 dCdsgyqGktC 32 
                 +C+sgy+Gk+C
  EFC35205.1 206 KCQSGYYGKKC 216
                 7********** PP

>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   6.2   0.00075       6.7      16      32 ..       4      20 ..       1      41 [. 0.85
   2 ?    0.5  11.3      0.08   7.1e+02      13      32 ..      41      59 ..      24      74 .. 0.80
   3 ?    0.4  12.8     0.083   7.4e+02      11      32 ..      84     115 ..      62     127 .. 0.57
   4 !   12.3  20.8   1.5e-05      0.14       3      45 ..     129     164 ..     113     168 .. 0.75
   5 !   12.5  15.6   1.4e-05      0.12       3      42 ..     168     215 ..     164     219 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00075
                 TTECESBTTTEESTTS- CS
  Laminin_EGF 16 stgqClCkenveGrkCd 32
                 stg+C+C  + +G+ C+
   EFC35205.1  4 STGVCDCPYGWTGDSCE 20
                 59**************8 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.08
                 EETTTECESBTTTEESTTS- CS
  Laminin_EGF 13 CdsstgqClCkenveGrkCd 32
                 C     +C+C+ +++G+kC 
   EFC35205.1 41 CID-IDRCQCNAGYSGTKCS 59
                 554.458************7 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.083
                  SSEET.........TTECES.BTTTEESTTS- CS
  Laminin_EGF  11 ssCds.........stgqCl.CkenveGrkCd 32 
                  ++C+          +  qC+ Ck  ++G kC+
   EFC35205.1  84 DKCQCaltlekgfwNGQQCDsCKLPYTGVKCN 115
                  33333445555555555666666666666665 PP

  == domain 4  score: 12.3 bits;  conditional E-value: 1.5e-05
                  CCTTTBCCSSEETTTECESBTTTEESTTS-EE-TTEEEGTTSC CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCdrCkpgyyglpsds 45 
                  C +h    ++C+s +g C C  n+ G++C+ Ck gyyg   d 
   EFC35205.1 129 CFGH----GKCNS-KGSCVCTGNFYGTNCNGCKTGYYGY--DC 164
                  3333....36776.***********************98..44 PP

  == domain 5  score: 12.5 bits;  conditional E-value: 1.4e-05
                  CCTTTBCC..SSEET.TTECESBTTT.....EESTTS-EE-TTEEEGT CS
  Laminin_EGF   3 Cnphgsss..ssCds.stgqClCken.....veGrkCdrCkpgyyglp 42 
                  C+p+ + s  + Cds   g+C C++n     ++G++C++C++gyyg++
   EFC35205.1 168 CDPKITCSgnGYCDSiLGGVCTCNNNlsngyFTGTNCNKCQSGYYGKK 215
                  777777766689**999*******984444458************984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (289 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       712  (0.0397122); expected 358.6 (0.02)
Passed bias filter:                      187  (0.01043); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1747.71
//
Query:       EFC35206.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.5e-16   58.4   0.3      8e-16   57.9   0.3    1.3  1  Zn-ribbon_8     Zinc ribbon domain
  ------ inclusion threshold ------
      0.021   15.2   0.5      0.027   14.8   0.1    1.5  1  DUF1178         Protein of unknown function (DUF1178)
      0.029   14.4   1.2        1.3    9.1   0.0    2.2  2  zf-ACC          Acetyl-coA carboxylase zinc finger domain
      0.036   14.0   1.0       0.66    9.9   0.1    2.1  2  Zn_ribbon_SprT  SprT-like zinc ribbon domain
      0.036   14.1   0.5      0.058   13.4   0.5    1.4  1  DZR             Double zinc ribbon
      0.077   12.4   2.9       0.98    8.9   0.1    2.3  2  zf-ribbon_3     zinc-ribbon domain
        0.1   12.6   0.2       0.14   12.2   0.2    1.2  1  DUF1451         Zinc-ribbon containing domain
       0.11   12.3   0.0       0.22   11.3   0.0    1.4  1  A2L_zn_ribbon   A2L zinc ribbon domain
       0.17   11.9   0.1       0.22   11.6   0.1    1.2  1  HypA            Hydrogenase/urease nickel incorporation, meta
       0.17   12.3   0.7        9.8    6.7   0.1    2.2  2  zf-IS66         zinc-finger binding domain of transposase IS6
       0.23   11.3   1.0         13    5.8   0.1    2.3  2  TFIIS_C         Transcription factor S-II (TFIIS)
       0.46   10.2   3.9        8.1    6.2   0.3    2.5  2  zf-NADH-PPase   NADH pyrophosphatase zinc ribbon domain
       0.88    9.4   4.9        3.1    7.7   0.2    2.3  2  zinc_ribbon_2   zinc-ribbon domain
        2.1    8.3   5.4        2.1    8.3   5.4    1.1  1  MSA-2c          Merozoite surface antigen 2c


Domain annotation for each model (and alignments):
>> Zn-ribbon_8  Zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.9   0.3   6.2e-19     8e-16       1      39 [.       1      40 [.       1      41 [. 0.95

  Alignments for each domain:
  == domain 1  score: 57.9 bits;  conditional E-value: 6.2e-19
  Zn-ribbon_8  1 MPiYeYrCeeCghefevlqsisdapltaCPeCgs.evrrv 39
                 MPiY Y+C +Cgh  +vl++isdaplt+CP+Cg+ +  ++
   EFC35206.1  1 MPIYAYKCGSCGHAKDVLRKISDAPLTTCPACGAeAFSKQ 40
                 **********************************887776 PP

>> DUF1178  Protein of unknown function (DUF1178)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.1   2.1e-05     0.027      27      80 ..      21      76 ..      13     100 .. 0.65

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.1e-05
     DUF1178 27 qkarglveCpvCgstevekalmaprvakskkkaaeaaeaeaaaaaakaaaa..aek 80
                 +++ l +Cp Cg ++ +k+l+a   + +++   +++ +++ +++a++ a   +++
  EFC35206.1 21 ISDAPLTTCPACGAEAFSKQLTAAGFQLKGSGWYATDFKNSGSKSAATPAPaaDTQ 76
                56677899***************998887766555444444433333332222222 PP

>> zf-ACC  Acetyl-coA carboxylase zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.3      0.04        51       3       9 ..       7      13 ..       6      14 .. 0.89
   2 ?    9.1   0.0     0.001       1.3       2      16 ..      27      41 ..      27      43 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.04
      zf-ACC  3 KCpsCge 9 
                KC sCg+
  EFC35206.1  7 KCGSCGH 13
                9****97 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.001
      zf-ACC  2 tKCpsCgemlykkeL 16
                t Cp+Cg+  + k+L
  EFC35206.1 27 TTCPACGAEAFSKQL 41
                68******9999988 PP

>> Zn_ribbon_SprT  SprT-like zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.1   0.00052      0.66       3      12 ..       4      13 ..       3      23 .. 0.79
   2 ?    2.8   0.1      0.09   1.2e+02       6      13 ..      28      35 ..      28      42 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00052
  Zn_ribbon_SprT  3 yvYrCtgCgr 12
                    y+Y+C++Cg 
      EFC35206.1  4 YAYKCGSCGH 13
                    99*******5 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.09
  Zn_ribbon_SprT  6 rCtgCgre 13
                    +C+ Cg e
      EFC35206.1 28 TCPACGAE 35
                    5*****65 PP

>> DZR  Double zinc ribbon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.5   4.5e-05     0.058      12      38 ..       5      36 ..       1      44 [. 0.75

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 4.5e-05
         DZR 12 arfCseCgtk...lkavaa..edrCpsCgekv 38
                a  C+ Cg++   l++ ++   ++Cp+Cg+++
  EFC35206.1  5 AYKCGSCGHAkdvLRKISDapLTTCPACGAEA 36
                5679****99665555444999*******986 PP

>> zf-ribbon_3  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.3     0.032        41      18      24 ..       7      13 ..       5      17 .. 0.62
   2 ?    8.9   0.1   0.00077      0.98       3      10 ..      27      34 ..      25      38 .. 0.76

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.032
  zf-ribbon_3 18 vCpyCGt 24
                 +C +CG+
   EFC35206.1  7 KCGSCGH 13
                 4555554 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00077
  zf-ribbon_3  3 vrCPnCGa 10
                 ++CP+CGa
   EFC35206.1 27 TTCPACGA 34
                 56888876 PP

>> DUF1451  Zinc-ribbon containing domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.2   0.00011      0.14     116     145 ..       7      39 ..       4      41 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00011
     DUF1451 116 vCekCgkelalkkt...eeippCpkCgateFrR 145
                  C +Cg+  ++ +      +++Cp+Cga+ F+ 
  EFC35206.1   7 KCGSCGHAKDVLRKisdAPLTTCPACGAEAFSK 39 
                 79****99887543222679***********86 PP

>> A2L_zn_ribbon  A2L zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00017      0.22       4      30 ..       6      35 ..       5      36 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00017
  A2L_zn_ribbon  4 kvCsvCggngiln...seqgylvCieCgas 30
                   ++C  Cg+ +++    s+     C+ Cga+
     EFC35206.1  6 YKCGSCGHAKDVLrkiSDAPLTTCPACGAE 35
                   79**********988899999*******96 PP

>> HypA  Hydrogenase/urease nickel incorporation, metallochaperone, hypA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   0.00017      0.22      71      97 ..       6      37 ..       2      50 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00017
                EEETTTS-EEE.CHH..HHH...S-TTTSSS-E CS
        HypA 71 vrCreCgkefe.lee..kal...rCpkCgsadv 97
                ++C +Cg+  + l++  + +   +Cp+Cg++ +
  EFC35206.1  6 YKCGSCGHAKDvLRKisD-ApltTCPACGAEAF 37
                68*****99994444432.24569*****9876 PP

>> zf-IS66  zinc-finger binding domain of transposase IS66
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.1     0.046        59       3       9 ..       7      13 ..       3      23 .. 0.60
   2 ?    6.7   0.1    0.0077       9.8       2      10 ..      27      36 ..      27      46 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.046
     zf-IS66  3 tCpcCGg 9 
                +C  CG+
  EFC35206.1  7 KCGSCGH 13
                3555555 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0077
     zf-IS66  2 rtCpcCGg.l 10
                +tCp CG+ +
  EFC35206.1 27 TTCPACGAeA 36
                68*****944 PP

>> TFIIS_C  Transcription factor S-II (TFIIS)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.1    0.0099        13      29      36 ..       6      13 ..       2      18 .. 0.74
   2 ?    4.2   0.1     0.031        40       2       9 ..      28      35 ..      27      41 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0099
     TFIIS_C 29 ykCtkCgh 36
                ykC +Cgh
  EFC35206.1  6 YKCGSCGH 13
                77777776 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.031
     TFIIS_C  2 kCpkCgsr 9 
                +Cp Cg +
  EFC35206.1 28 TCPACGAE 35
                8****976 PP

>> zf-NADH-PPase  NADH pyrophosphatase zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.4      0.02        26       6      11 ..       8      13 ..       4      15 .. 0.69
   2 ?    6.2   0.3    0.0063       8.1      24      31 ..      29      36 ..      28      38 .. 0.75

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.02
  zf-NADH-PPase  6 CgrCGa 11
                   Cg CG+
     EFC35206.1  8 CGSCGH 13
                   666665 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0063
  zf-NADH-PPase 24 CpaCgleh 31
                   CpaCg+e 
     EFC35206.1 29 CPACGAEA 36
                   88888875 PP

>> zinc_ribbon_2  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.9     0.056        72      16      21 ..       8      13 ..       4      15 .. 0.63
   2 ?    7.7   0.2    0.0024       3.1      15      22 ..      28      35 ..      26      36 .. 0.69

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.056
  zinc_ribbon_2 16 CpyCGt 21
                   C  CG+
     EFC35206.1  8 CGSCGH 13
                   555555 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0024
  zinc_ribbon_2 15 FCpyCGtp 22
                    Cp CG++
     EFC35206.1 28 TCPACGAE 35
                   57777764 PP

>> MSA-2c  Merozoite surface antigen 2c
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   5.4    0.0017       2.1     153     187 ..      59     102 ..      18     105 .] 0.61

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0017
      MSA-2c 153 kPsrtssaetPaPsd...aesaaaqP......PeskpaqaPaPt 187
                 k s ++sa tPaP+    a +++a P      P++ pa aPaP 
  EFC35206.1  59 KNSGSKSAATPAPAAdtqASDTSAAPaatapaPAAAPASAPAPS 102
                 66778888888775411133444445333334555666666664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       703  (0.0392102); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.48u 0.33s 00:00:00.81 Elapsed: 00:00:00.51
# Mc/sec: 623.45
//
Query:       EFC35207.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       312  (0.017402); expected 358.6 (0.02)
Passed bias filter:                      165  (0.00920297); expected 358.6 (0.02)
Passed Vit filter:                         8  (0.000446204); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.34s 00:00:00.84 Elapsed: 00:00:00.53
# Mc/sec: 692.36
//
Query:       EFC35208.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0072   16.2   2.6        2.4    8.2   0.1    3.1  3  ApoC-I        Apolipoprotein C-I (ApoC-1)
  ------ inclusion threshold ------
       0.22   11.5   2.9       0.27   11.2   0.4    2.1  2  TnpV          Transposon-encoded protein TnpV
       0.39   11.5   6.2       0.32   11.7   4.3    1.8  1  COMPASS-Shg1  COMPASS (Complex proteins associated with Set1p
        4.2    8.0   8.2         14    6.3   0.4    2.9  3  DUF643        Protein of unknown function (DUF643)


Domain annotation for each model (and alignments):
>> ApoC-I  Apolipoprotein C-I (ApoC-1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.1   0.00053       2.4       7      35 ..      67      95 ..      63     101 .. 0.85
   2 !    6.5   0.0    0.0018       7.9       7      31 ..     109     133 ..     105     143 .. 0.81
   3 ?   -0.4   0.1      0.24   1.1e+03      29      39 ..     156     166 ..     144     169 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00053
                SC....HHHCHHHHHHHHHHCCHCCCHCT CS
      ApoC-I  7 afeslpdklkEfgktledKaraaieeIkq 35
                a++s  + +kE+++ l +K  +++e+ kq
  EFC35208.1 67 AMQSTLQSVKEMSNNLMEKGGELFENGKQ 95
                56666689****************99877 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0018
                 SC....HHHCHHHHHHHHHHCCHCC CS
      ApoC-I   7 afeslpdklkEfgktledKaraaie 31 
                 +++s  + +kE +++l +K+  +++
  EFC35208.1 109 TLQSALQSVKETSNDLLEKTIDFVK 133
                 44455589************87765 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.24
                 HCCCHCTTSSS CS
      ApoC-I  29 aieeIkqSelp 39 
                  +e Ikq e+ 
  EFC35208.1 156 EFETIKQEEIV 166
                 5899***9986 PP

>> TnpV  Transposon-encoded protein TnpV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1       0.2   9.1e+02      39      68 ..      55      84 ..      50      92 .. 0.62
   2 ?   11.2   0.4   6.1e-05      0.27      36      88 ..      94     146 ..      88     170 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.2
        TnpV 39 kkvlYtelllsgkLnehlaeideqaeerle 68
                kk    +++ s+ +++ l+++ e +++++e
  EFC35208.1 55 KKQILAKIVNSKAMQSTLQSVKEMSNNLME 84
                444445555566666666666666666555 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 6.1e-05
        TnpV  36 kehkkvlYtelllsgkLnehlaeideqaeerlerlvkqlaekegvteelkakd 88 
                 k++  ++Y+++  s++L++ l+++ e+++++le+ ++ ++++ +v  + ++++
  EFC35208.1  94 KQEVSAQYSKVSNSETLQSALQSVKETSNDLLEKTIDFVKQQLDVIPPSEQES 146
                 5677899******************************9999988865555544 PP

>> COMPASS-Shg1  COMPASS (Complex proteins associated with Set1p) component shg1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   4.3   7.2e-05      0.32      15      88 ..      54     126 ..      51     146 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7.2e-05
  COMPASS-Shg1  15 lRkeiledfkeseaeqnlrkkveeivesevkkdpsllfknrgkaaaliegeidrsdvykkleegvdrivdqdlq 88 
                   ++k+il+++ +s+a q  +++v+e+ ++ ++k  +l  + +++++a+  +++ +s+ ++++ ++v+++ ++ l+
    EFC35208.1  54 YKKQILAKIVNSKAMQSTLQSVKEMSNNLMEKGGELFENGKQEVSAQY-SKVSNSETLQSALQSVKETSNDLLE 126
                   79*************************************999999986.5677778888777666666555544 PP

>> DUF643  Protein of unknown function (DUF643)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.4    0.0032        14      61     108 ..      42      88 ..      22      92 .. 0.79
   2 ?    4.8   0.2    0.0095        43      45      73 ..     108     136 ..      90     139 .. 0.73
   3 ?    0.5   0.1       0.2   8.9e+02      55      89 ..     163     199 ..     153     212 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0032
      DUF643  61 iiepekefikdvlkdknlikkyknsknlkvdfsykkGmlekclkklGe 108
                 i+ +   +  d+  +k+++ k  nsk+++  +   k m +  ++k Ge
  EFC35208.1  42 IV-SITTIGHDIEYKKQILAKIVNSKAMQSTLQSVKEMSNNLMEKGGE 88 
                 44.34456788999999999999*****99999999999999999887 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0095
      DUF643  45 eykiktGksveeiindiiepekefikdvl 73 
                 e    + +sv+e  nd++e + +f+k+ l
  EFC35208.1 108 ETLQSALQSVKETSNDLLEKTIDFVKQQL 136
                 344556689*****************877 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.2
      DUF643  55 eeiindiiepekefikdvlkdknli..kkyknsknlk 89 
                 eei+++  +++k+ +k+   + +++   ky +  n+k
  EFC35208.1 163 EEIVESAGDSSKKEVKQEESSTEITihPKYSDRMNFK 199
                 6888888888888888776666555114555544544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2072  (0.115567); expected 358.6 (0.02)
Passed bias filter:                      647  (0.0360868); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1339.59
//
Query:       EFC35209.1  [L=262]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.9e-05   23.3   0.0    8.7e-05   22.5   0.0    1.5  1  PX          PX domain


Domain annotation for each model (and alignments):
>> PX  PX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0   4.9e-09   8.7e-05      32     111 ..     117     198 ..      70     200 .. 0.82

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 4.9e-09
                 SSEEEEEEEHHHHHHHHHHHHHHHTTSTSTSSSTSGSSSSS.....CTTSHHHHHHHHHHHHHHHHHHHTSCHHHHSHHHHHHHH CS
          PX  32 akewtvkRrYsdFeeLhskLlrkfprvkiPplPkkvlfgsv.....rkkdeefiekrrkgLeeyLqrllnhpelrnsevlteFLe 111
                 ++  tv+R+ +dFe+L+++L+    ++ iP   +k+l+ ++     ++ +++    + k+L  +L  +++hp l++s  + +F++
  EFC35209.1 117 KTGLTVSRKMKDFEWLYENLKIDCIGCLIP---PKDLLTTNidklyEQTSTDPKILKGKYLSLFLSFCARHPILCKSYLFWDFIS 198
                 55689***************9998877775...5555555555555777777777789*********************999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (262 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1553  (0.0866194); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 1472.02
//
Query:       EFC35210.1  [L=278]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-16   60.4   0.4    3.5e-16   59.3   0.3    1.5  2  BTB_2     BTB/POZ domain
    6.8e-07   29.4   0.3    1.2e-06   28.7   0.3    1.3  1  SPRY      SPRY domain


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.3   0.3   3.9e-20   3.5e-16       1      88 [.       5      95 ..       5      99 .. 0.91
   2 ?   -3.3   0.0       1.4   1.2e+04       2      25 ..     184     207 ..     184     220 .. 0.67

  Alignments for each domain:
  == domain 1  score: 59.3 bits;  conditional E-value: 3.9e-20
                EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS....S-B---TTS-HHHHHHHHHHHT--T CS
       BTB_2  1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtg...gkLhrpeevelkslleElefyglee 88
                vklnVgG++f+t+  t++   dt+++   +     +++e++n++f+DR ++ F+ iLny+r      kL   +e +l+ + eE+ +y+l++
  EFC35210.1  5 VKLNVGGKIFATNLATITSVKDTFFTGYFNDLFNPTAEEDDNSFFIDRPNEQFHLILNYLRGIdisSKLSSLNEHDLNDFIEEIVYYQLTS 95
                89***********************999984448999************************74345789999****************986 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.4
                 EEEETTEEEEEEHHHHHTSTTSTT CS
       BTB_2   2 klnVgGtrfetskstLsrkpdtlL 25 
                 ++n+ G++++     L +  +++L
  EFC35210.1 184 TININGSNYNSCGYYLYCAGNGYL 207
                 588888888776666666666665 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.3   1.3e-10   1.2e-06      14     117 ..     174     275 ..     163     277 .. 0.75

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 1.3e-10
                 SEEEEEEEETTSSSSSTSSSTSSTTE...EEEETETTEEE..EETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTEEEEEEEESTTTS.SEEEEEE CS
        SPRY  14 gsisvGlateqtdlsdksgegddrgs...wglcgdngtrt..saeqskaygkqparegdviGvalDleegelsFtkngknlgvaFrnvrga.elfPvvs 106
                  ++++G+a + ++ +     g+++ s   + +c  ng  +  +  + k+y + +   g +i + l   +g +sF  n k+ gvaF++++++ el+P++ 
  EFC35210.1 174 ANLMIGFAPKTININ-----GSNYNScgyYLYCAGNGYLFseRGDSCKSYINSRIVDGSIIECEL--RNGNISFKVNDKDYGVAFSEITNEnELYPAFN 265
                 567788887777744.....5556663336666666777677777777787889999******76..567********************99******9 PP

                 E.STCEEEEES CS
        SPRY 107 lgngaslkinl 117
                 l ++  +++++
  EFC35210.1 266 L-ANVDCTFEF 275
                 9.666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (278 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       456  (0.0254337); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1753.71
//
Query:       EFC35211.1  [L=175]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       856  (0.0477439); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1004.63
//
Query:       EFC35212.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.079   12.7   0.1       0.14   11.9   0.1    1.3  1  DUF3464   Photosynthesis affected mutant 68


Domain annotation for each model (and alignments):
>> DUF3464  Photosynthesis affected mutant 68
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   7.8e-06      0.14      77     109 ..      74     106 ..      71     107 .. 0.94

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 7.8e-06
     DUF3464  77 tfvvfylivskelvdlptwvvllvslvlFglgv 109
                 +f ++y+  ++++++l+t+++ll + +lFg+++
  EFC35212.1  74 MFLLYYYSTNQKKMKLQTFAILLLNCLLFGVAL 106
                 7999**************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       576  (0.0321267); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 1244.16
//
Query:       EFC35213.1  [L=235]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.9e-13   47.7   0.3    0.00025   20.9   0.0    4.1  5  NHL       NHL repeat
  ------ inclusion threshold ------
       0.21   11.9   0.0        1.8    9.0   0.0    2.1  2  DUF2573   Protein of unknown function (DUF2573)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.65   5.8e+03      19      28 .]      19      28 ..      18      28 .. 0.84
   2 !   20.9   0.0   2.8e-08   0.00025       5      27 ..      32      54 ..      28      55 .. 0.87
   3 !   10.4   0.0   5.9e-05      0.53       4      27 ..      89     112 ..      88     113 .. 0.89
   4 !   11.7   0.0   2.3e-05      0.21       1      27 [.     144     170 ..     144     171 .. 0.93
   5 ?   -2.8   0.0      0.92   8.2e+03       4      16 ..     202     213 ..     201     219 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.65
                ECCCTEEEEE CS
         NHL 19 DsenhrvqvF 28
                D+en +v +F
  EFC35213.1 19 DNENVTVAKF 28
                9999999888 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 2.8e-08
                EEEEEETTTEEEEEECCCTEEEE CS
         NHL  5 hGvavdsnGdiyVaDsenhrvqv 27
                + +a +s G++++aD +nhr+++
  EFC35213.1 32 QHIAFNSLGELVIADVYNHRIRK 54
                5699*****************86 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 5.9e-05
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P G ++++ +++++a+++n+r+++
  EFC35213.1  89 PYGFCYTKYNELIIAETNNNRLRK 112
                 568899999************986 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 2.3e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P++v   ++Gdiy +D+ n r+++
  EFC35213.1 144 LNNPRSVYCADSGDIYFTDTDNYRIRK 170
                 7899999999***************86 PP

  == domain 5  score: -2.8 bits;  conditional E-value: 0.92
                 EEEEEEETTTEEE CS
         NHL   4 PhGvavdsnGdiy 16 
                 P  v+++ nG +y
  EFC35213.1 202 PLFVTIF-NGTLY 213
                 7788888.77776 PP

>> DUF2573  Protein of unknown function (DUF2573)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.11   9.9e+02      15      42 ..      40      67 ..      35      69 .. 0.88
   2 ?    9.0   0.0    0.0002       1.8      11      40 ..      94     123 ..      88     128 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.11
     DUF2573 15 tELLlGesseelkekvkvwilYshiaKs 42
                 EL++ +  + ++ kv v  + s+ia s
  EFC35213.1 40 GELVIADVYNHRIRKVAVNGIVSTIAGS 67
                69999*************9999999976 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0002
     DUF2573  11 veKytELLlGesseelkekvkvwilYshia 40 
                 + Ky EL++ e+++++  kv    + +++a
  EFC35213.1  94 YTKYNELIIAETNNNRLRKVSSSGIITTLA 123
                 68*****************99877777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       422  (0.0235373); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1417.65
//
Query:       EFC35214.1  [L=360]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2677  (0.149311); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                       263  (0.014669); expected 17.9 (0.001)
Passed Fwd filter:                        82  (0.0045736); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.90u 0.44s 00:00:02.34 Elapsed: 00:00:00.64
# Mc/sec: 1700.53
//
Query:       EFC35215.1  [L=301]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       304  (0.0169558); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1703.51
//
Query:       EFC35216.1  [L=215]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-11   43.1   0.2    1.9e-10   40.9   0.0    2.0  3  BTB       BTB/POZ domain
     0.0015   18.6   0.1     0.0054   16.8   0.0    1.9  2  BACK      BTB And C-terminal Kelch
  ------ inclusion threshold ------
      0.034   12.8   0.0      0.044   12.5   0.0    1.1  1  AXE1      Acetyl xylan esterase (AXE1)


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.9   0.0   3.2e-14   1.9e-10      23     107 ..      63     145 ..      57     149 .. 0.92
   2 ?   -0.9   0.0      0.31   1.8e+03      86     109 ..     156     179 ..     150     181 .. 0.82
   3 ?   -1.7   0.0      0.56   3.3e+03      82      99 ..     179     196 ..     160     207 .. 0.51

  Alignments for each domain:
  == domain 1  score: 40.9 bits;  conditional E-value: 3.2e-14
                 EEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHHHHHH CS
         BTB  23 fkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlkkaceefl 107
                 + +h++++ +rSp+F+++f   ++ es+  +++l+d + e++ ++L+++Yt++++++   n   +L    +l++ +++ +c +++
  EFC35216.1  63 IAVHRLIM-SRSPFFSRMFVTSGMMESKERVVHLTDYSTEVMLEVLSYLYTDTIRLS-PRNCLGILVYCIMLDLVDMASVCRRMV 145
                 67899997.59***********888888899*************************6.***********************9876 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.31
                 HHHHHHHHHT-HHHHHHHHHHHHH CS
         BTB  86 elLaaadllqiprlkkaceeflkq 109
                 +++ +a l++ + l  +ce+++ +
  EFC35216.1 156 SVIDIAMLYNDKTLESECEHYILN 179
                 577889999999999999999865 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.56
                 GGHHHHHHHHHHHT-HHH CS
         BTB  82 enleelLaaadllqiprl 99 
                 +n e+l  aa +l++p+l
  EFC35216.1 179 NNFEKLRGAAGFLNLPEL 196
                 344444445555555555 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.46   2.8e+03       1      25 [.     122     146 ..     122     151 .. 0.84
   2 !   16.8   0.0     9e-07    0.0054       4      42 ..     157     195 ..     154     203 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.46
        BACK   1 clgilefAeaysceeLaeaakefil 25 
                 clgil ++ ++ + ++a+++++++ 
  EFC35216.1 122 CLGILVYCIMLDLVDMASVCRRMVV 146
                 8999999999999999999999875 PP

  == domain 2  score: 16.8 bits;  conditional E-value: 9e-07
        BACK   4 ilefAeaysceeLaeaakefilknfeevlkseeFleLsk 42 
                 + ++A  y+ + L++ ++++il+nfe++     Fl+L+ 
  EFC35216.1 157 VIDIAMLYNDKTLESECEHYILNNFEKLRGAAGFLNLPE 195
                 7899********************************986 PP

>> AXE1  Acetyl xylan esterase (AXE1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   7.4e-06     0.044     212     304 ..      90     186 ..      70     192 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.4e-06
                 HHHHHH-S..STTCHHHHHHHHHSH-CCHHHHHHHHHHTT-HHHHHCC--S-EEEEEE.TT-SSS-HHHHHHH.HHH--SSEEEEEETT-STTTTHH CS
        AXE1 212 kRvvelal..eeaYdEitrylkldperekeeevletLsYiDvknlAkrvkaevllsvg.LeDevcpPstvfaa.ynkletekeikvyeefahealka 304
                 +Rvv+l++  +e   E+ +yl +d+ r    + l  L Y  + +l + + +  +++v+ LeD++    +  a+ yn  + e e + y  ++ e+l++
  EFC35216.1  90 ERVVHLTDysTEVMLEVLSYLYTDTIRLSPRNCLGILVYCIMLDLVDMASVCRRMVVSlLEDSIVWSVIDIAMlYNDKTLESECEHYILNNFEKLRG 186
                 79999998778899*************************88778877777778888883589999999999966***********999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       394  (0.0219756); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1330.72
//
Query:       EFC35217.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-27   94.1  17.1    4.2e-11   42.4   0.6    4.2  4  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.018   14.4   0.3      0.029   13.7   0.3    1.4  1  6PF2K     6-phosphofructo-2-kinase


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   1.4   3.3e-07    0.0029      18      49 .]      63      94 ..      27      94 .. 0.92
   2 !   42.4   0.6   4.7e-15   4.2e-11       1      49 []      71     119 ..      71     119 .. 0.94
   3 !   40.2   0.1   2.2e-14     2e-10       1      49 []      96     145 ..      96     145 .. 0.96
   4 !   22.4   0.1   8.4e-09   7.6e-05       1      32 [.     121     153 ..     121     155 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.3e-07
     DUF4116 18 ylseeLknDkeivlkAvkqngtalsyaseeLr 49
                ++se ++n+ ei+lkA++ + + ++ as+eL+
  EFC35217.1 63 FISECMRNNEEIMLKAIRLDFCRIYDASNELK 94
                89999***************999999999996 PP

  == domain 2  score: 42.4 bits;  conditional E-value: 4.7e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++Ei+l+a++ + + ++ +s+eLk+++e+v+kA++ ng a++ + +eLr
  EFC35217.1  71 NEEIMLKAIRLDFCRIYDASNELKKNREFVMKALRVNGRAFELMVNELR 119
                 79**************************************998877776 PP

  == domain 3  score: 40.2 bits;  conditional E-value: 2.2e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq.ngtalsyaseeLr 49 
                 +rE+v++a++ ng a++   +eL+nD e+v  A+++ +g+al++a e+Lr
  EFC35217.1  96 NREFVMKALRVNGRAFELMVNELRNDQELVRLAIENgCGDALEFANEDLR 145
                 8**********************************86779*********8 PP

  == domain 4  score: 22.4 bits;  conditional E-value: 8.4e-09
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlk 32 
                 D E+v  a+++  g al++++e+L++D+e+vlk
  EFC35217.1 121 DQELVRLAIENGcGDALEFANEDLRSDRELVLK 153
                 669999999975467*****************9 PP

>> 6PF2K  6-phosphofructo-2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.3   3.2e-06     0.029     101     145 ..      86     131 ..      61     147 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.2e-06
                 EEES---SHHHHHHHHHHHHHTT.-EEEEEEEE--HHHHHHHHHHH CS
       6PF2K 101 ifDAtNttrerRklilefveenn.lkvlflesicsdeeiikeNike 145
                 i+DA N  +++R+++++ ++ n+    l+++ + +d+e+++  i++
  EFC35217.1  86 IYDASNELKKNREFVMKALRVNGrAFELMVNELRNDQELVRLAIEN 131
                 9******************9998566799999********988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.28s 00:00:00.71 Elapsed: 00:00:00.43
# Mc/sec: 1103.22
//
Query:       EFC35218.1  [L=314]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0056   16.9   3.0     0.0056   16.9   3.0    3.9  4  KxDL             Uncharacterized conserved protein
  ------ inclusion threshold ------
      0.092   13.1   0.9        4.3    7.8   0.0    3.5  3  HHH_8            Helix-hairpin-helix domain
       0.21   11.6  22.0       0.13   12.3   5.3    4.0  4  SOAR             STIM1 Orai1-activating region
       0.83   10.1  28.8        2.4    8.6   0.7    5.5  5  FlaC_arch        Flagella accessory protein C (FlaC)
       0.88   10.1  18.4        4.2    7.9   0.4    5.1  5  NPV_P10          Nucleopolyhedrovirus P10 protein
        1.3    9.4  13.3       0.13   12.6   1.0    3.1  3  DUF5517          Family of unknown function (DUF5517)
        1.6    9.3  22.3        1.8    9.2   0.6    4.7  4  Syntaxin-6_N     Syntaxin 6, N-terminal
        2.2    7.4  26.0        1.8    7.7   6.8    3.1  3  TMPIT            TMPIT-like protein
        4.3    7.4  31.5       0.15   12.2   5.7    3.6  3  Mod_r            Modifier of rudimentary (Mod(r)) protein
        4.7    7.5  33.3        2.2    8.5   3.4    4.9  5  Seryl_tRNA_N     Seryl-tRNA synthetase N-terminal domain
        6.8    6.7  23.4       0.43   10.6   1.1    4.0  4  DUF1664          Protein of unknown function (DUF1664)
        8.4    7.1  18.7         10    6.8   1.8    4.5  4  SlyX             SlyX


Domain annotation for each model (and alignments):
>> KxDL  Uncharacterized conserved protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   3.0   3.7e-06    0.0056      15      75 ..      33      94 ..      26      99 .. 0.86
   2 ?   -1.5   0.0       2.1   3.1e+03      28      42 ..      98     112 ..      95     126 .. 0.83
   3 !    6.0   2.1      0.01        15      23      79 ..     128     183 ..     124     188 .. 0.82
   4 ?    0.8   0.1      0.41   6.1e+02      39      64 ..     213     238 ..     203     245 .. 0.50

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 3.7e-06
        KxDL 15 lalQaqtsgrlnkknreLlelnalsqerlaklra..rfkqgtkllkevkkdLesifkkirslk 75
                l+ Q++t  +l +kn+ L+++ ++++ r  ++++  r+ +  ++++++kk+L+ i k+i+ + 
  EFC35218.1 33 LSEQEKTIRTLCEKNESLENQLKEAS-RIPNVKQvvRIPKASQTIHSLKKELNRIEKQISEMS 94
                789*****************999986.677777622566788******************986 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 2.1
        KxDL  28 knreLlelnalsqer 42 
                 kn e +eln+l++er
  EFC35218.1  98 KNIEFKELNQLLEER 112
                 678899999999987 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.01
        KxDL  23 grlnkknreLlelnalsqerlaklrarfk..qgtkllkevkkdLesifkkirslkakla 79 
                 +++ + +reL + ++ +++ l +++ +f+  q+++ lk  kkdL   fk +  +k+k++
  EFC35218.1 128 DEFDNDKRELINEIERVENSLREHEVNFEcfQNVNKLKLKKKDL---FKSLAEIKDKIE 183
                 6789999*********************9667778888888887...666777777665 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.41
        KxDL  39 sqerlaklrarfkqgtkllkevkkdL 64 
                 ++++l+++ +++ +  +  +e+++dL
  EFC35218.1 213 LEKKLSDMIQELSNMHERKSEIQNDL 238
                 33344444444444444444444444 PP

>> HHH_8  Helix-hairpin-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       1.4   2.2e+03      34      55 ..      39      63 ..      17      68 .. 0.64
   2 ?    7.8   0.0    0.0029       4.3      30      59 ..      71     100 ..      69     110 .. 0.89
   3 ?    0.9   0.1       0.4     6e+02      34      65 ..     209     223 ..     192     237 .. 0.65

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.4
                CCCC-SS-HHHH.TT..HCTTSTT- CS
       HHH_8 34 aiealpeeitsl.ee..eltklpgi 55
                +i+ l e+ +sl  +  e++++p++
  EFC35218.1 39 TIRTLCEKNESLeNQlkEASRIPNV 63
                3444444445553234447777776 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0029
                 HHHCCCCC-SS-HHHH.TTHCTTSTT--HHH CS
       HHH_8  30 rAaraiealpeeitsl.eeeltklpgiGkki 59 
                 +A ++i +l++e++ + ++ ++++  +Gk i
  EFC35218.1  71 KASQTIHSLKKELNRIeKQ-ISEMSTCGKNI 100
                 899*************666.********998 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.4
                 CCCC-SS-HHHHTTHCTTSTT--HHHHHHHHH CS
       HHH_8  34 aiealpeeitsleeeltklpgiGkkiaakiee 65 
                  ie+l++++ ++                 i+e
  EFC35218.1 209 EIERLEKKLSDM-----------------IQE 223
                 455555555555.................333 PP

>> SOAR  STIM1 Orai1-activating region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.5      0.22   3.3e+02      41      87 ..      12      58 ..       6      70 .. 0.74
   2 ?    4.5   0.2     0.023        35      64      94 ..      71     101 ..      62     109 .. 0.85
   3 ?    5.2   0.2     0.014        21      59      96 ..     124     161 ..     119     166 .. 0.86
   4 ?   12.3   5.3   8.5e-05      0.13      17      95 ..     159     236 ..     153     241 .. 0.94

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.22
        SOAR 41 eklkkkrssllgslrlahssslddvdkkileakqaleevtkelkerq 87
                +k+ + r + l +l  ++  +l++ +k i ++ ++ e+++++lke +
  EFC35218.1 12 DKISQLRIQHLEKLLKVNEYNLSEQEKTIRTLCEKNESLENQLKEAS 58
                56666666666667777778888888888888888888888888865 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.023
        SOAR  64 dvdkkileakqaleevtkelkerqeRWqqie 94 
                 +  + i+++k++l++++k+++e+++  ++ie
  EFC35218.1  71 KASQTIHSLKKELNRIEKQISEMSTCGKNIE 101
                 56789*****************998777776 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.014
        SOAR  59 ssslddvdkkileakqaleevtkelkerqeRWqqiekl 96 
                 s +ld++d+   e+ +++e+v+++l+e++  ++  +++
  EFC35218.1 124 SGKLDEFDNDKRELINEIERVENSLREHEVNFECFQNV 161
                 6789************************9887766655 PP

  == domain 4  score: 12.3 bits;  conditional E-value: 8.5e-05
        SOAR  17 lElkylnkkkqeaekqlqeAkeeveklkkkrssllgslrlahssslddvdkkileakqaleevtkelkerqeRWqqiek 95 
                 + +++l+ kk++  k l+e k+++e ++  + +l+ +++  + +++ +v+ +i ++ ++l+++ +el++++eR ++i++
  EFC35218.1 159 QNVNKLKLKKKDLFKSLAEIKDKIEDIEYAKDTLIFEIKTQKRNKIGKVE-EIERLEKKLSDMIQELSNMHERKSEIQN 236
                 5678999******************************************7.7*********************999985 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   4.3      0.17   2.5e+02       1      38 [.      18      55 ..       7      69 .. 0.87
   2 ?    8.6   0.7    0.0016       2.4       9      34 ..      69      94 ..      59     110 .. 0.89
   3 ?    1.2   0.1      0.33     5e+02      25      38 ..     136     149 ..     120     164 .. 0.54
   4 ?    6.1   0.9    0.0096        14       2      39 ..     141     184 ..     139     193 .. 0.88
   5 ?    6.9   2.0    0.0054       8.1       2      33 ..     210     241 ..     206     249 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.17
   FlaC_arch  1 ridelEnklsklsteletvkkeneelsksveelkenVk 38
                ri+ lE+ l+  + +l+  +k++  l ++ e l+ + k
  EFC35218.1 18 RIQHLEKLLKVNEYNLSEQEKTIRTLCEKNESLENQLK 55
                78899999999999999999999999999999988776 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0016
   FlaC_arch  9 lsklsteletvkkeneelsksveelk 34
                ++k s ++ ++kke++ ++k++ e+ 
  EFC35218.1 69 IPKASQTIHSLKKELNRIEKQISEMS 94
                789999999*********99999986 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.33
   FlaC_arch  25 elsksveelkenVk 38 
                 el +++e+++ + +
  EFC35218.1 136 ELINEIERVENSLR 149
                 44444444444332 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0096
   FlaC_arch   2 idelEnklsklst......eletvkkeneelsksveelkenVkd 39 
                 i+ +En l ++++      +++ +k + ++l ks+ e+k++++d
  EFC35218.1 141 IERVENSLREHEVnfecfqNVNKLKLKKKDLFKSLAEIKDKIED 184
                 67889999999998888889999999999999999999999987 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0054
   FlaC_arch   2 idelEnklsklsteletvkkeneelsksveel 33 
                 i+ lE+kls++  el+++ +  +e+++++ el
  EFC35218.1 210 IERLEKKLSDMIQELSNMHERKSEIQNDLMEL 241
                 7889*********************9998776 PP

>> NPV_P10  Nucleopolyhedrovirus P10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.8       0.1   1.5e+02      22      73 ..       9      63 ..       2      65 .. 0.56
   2 ?    5.5   0.5     0.016        24      26      61 ..      65     100 ..      63     153 .. 0.85
   3 ?    3.4   0.8     0.073   1.1e+02      34      62 ..     158     186 ..     132     192 .. 0.81
   4 ?    7.9   0.4    0.0028       4.2      33      74 ..     206     246 ..     188     248 .. 0.85
   5 ?   -1.4   0.0       2.2   3.3e+03      19      41 ..     274     296 ..     272     303 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.1
     NPV_P10 22 alqqqvddvq.enlpdvtelne.kLdaqsaqLaeletkvenIqdiLnpde.vPdl 73
                 l++++ +++ + l+++ ++ne +L +q +++ +l +k e+ ++ L +   +P++
  EFC35218.1  9 ELKDKISQLRiQHLEKLLKVNEyNLSEQEKTIRTLCEKNESLENQLKEASrIPNV 63
                4444444444222333333333257777777777777777777777755567766 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.016
     NPV_P10  26 qvddvqenlpdvtelnekLdaqsaqLaeletkvenI 61 
                 qv ++ + +++++ l+++L+++ +q+ e++t  +nI
  EFC35218.1  65 QVVRIPKASQTIHSLKKELNRIEKQISEMSTCGKNI 100
                 777888899999999999999999999999954444 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.073
     NPV_P10  34 lpdvtelnekLdaqsaqLaeletkvenIq 62 
                 +++v++l+ k  ++ ++Lae+++k+e+I+
  EFC35218.1 158 FQNVNKLKLKKKDLFKSLAEIKDKIEDIE 186
                 5788888888899999999**99999996 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0028
     NPV_P10  33 nlpdvtelnekLdaqsaqLaeletkvenIqdiLnpdevPdlp 74 
                 ++++++ l++kL ++ ++L ++++  ++Iq+ L  + +P+ p
  EFC35218.1 206 KVEEIERLEKKLSDMIQELSNMHERKSEIQNDLM-ELIPKFP 246
                 5788999************************999.6788877 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 2.2
     NPV_P10  19 kVdalqqqvddvqenlpdvteln 41 
                 +V alq+++  +++++ + t+++
  EFC35218.1 274 RVFALQNSILLLNTQFSNYTNIQ 296
                 57788998888888877777665 PP

>> DUF5517  Family of unknown function (DUF5517)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   1.0   8.6e-05      0.13      38      93 ..      31      88 ..      20      95 .. 0.84
   2 ?    3.2   2.4     0.071   1.1e+02      39      76 ..     126     163 ..     103     185 .. 0.84
   3 ?   -1.6   0.1       2.2   3.3e+03      41      50 ..     208     217 ..     177     244 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 8.6e-05
                EEETTTEEEEEEEESTT--HHHHHHHHHHHHHHHTT--STTHHHHHH..HHHHHHHHH CS
     DUF5517 38 ieldedeklekeiyadniklenelrqlkrlyevyqsveiddaqkaiq..kealltiak 93
                 +l e+ek  + +   n  len+l++  r+ +v q v i  a ++i+  k+ l  i k
  EFC35218.1 31 YNLSEQEKTIRTLCEKNESLENQLKEASRIPNVKQVVRIPKASQTIHslKKELNRIEK 88
                47999*************************************9998633555656655 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.071
                 EETTTEEEEEEEESTT--HHHHHHHHHHHHHHHTT--S CS
     DUF5517  39 eldedeklekeiyadniklenelrqlkrlyevyqsvei 76 
                 +lde ++ ++e+  +  ++en lr+    +e +q v+ 
  EFC35218.1 126 KLDEFDNDKRELINEIERVENSLREHEVNFECFQNVNK 163
                 57888888899999999*****************9975 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 2.2
                 TTTEEEEEEE CS
     DUF5517  41 dedeklekei 50 
                 +e e+lek++
  EFC35218.1 208 EEIERLEKKL 217
                 3334444433 PP

>> Syntaxin-6_N  Syntaxin 6, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.3     0.082   1.2e+02      53      90 ..       3      42 ..       2      46 .. 0.72
   2 ?    9.2   0.6    0.0012       1.8      12      61 ..      45      94 ..      37     104 .. 0.75
   3 ?    1.8   8.8      0.23   3.5e+02       9      98 ..     136     227 ..      99     244 .. 0.69
   4 ?   -2.9   0.0       6.9     1e+04      11      31 ..     279     299 ..     277     308 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.082
  Syntaxin-6_N 53 iewdledLeetvriveknp.sk.fkidekelsrrrafvee 90
                  +e++l++L++ ++ ++ +  +k  k++e  ls++++ ++ 
    EFC35218.1  3 LEYTLDELKDKISQLRIQHlEKlLKVNEYNLSEQEKTIRT 42
                  7889999999998776554466777777777777777765 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0012
  Syntaxin-6_N 12 kslnkaeslyrrwerlledtssstseeldetrteLrkalrsiewdledLe 61
                  ++ +++e+ +++ +r+ ++++  + ++ ++t + L+k+l+ ie++++++ 
    EFC35218.1 45 EKNESLENQLKEASRIPNVKQVVRIPKASQTIHSLKKELNRIEKQISEMS 94
                  333444444444466666666669***********************986 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.23
  Syntaxin-6_N   9 eVqkslnkaeslyrrwerlledtsss.....tseeldetrteLrkalrsiewdledLeetvr..iveknpsk.fkide.kelsrrrafveevreevk 96 
                   e  ++++++e+ +r+ e        +     + ++l+  +++L k+l +i+ ++ed+e + +  i e + +k  ki + +e++r ++ ++++ +e++
    EFC35218.1 136 ELINEIERVENSLREHEV-------NfecfqNVNKLKLKKKDLFKSLAEIKDKIEDIEYAKDtlIFEIKTQKrNKIGKvEEIERLEKKLSDMIQELS 225
                   444444444444444432.......022222467888888889999999999999888776522445555444777654677777777888777777 PP

  Syntaxin-6_N  97 em 98 
                   +m
    EFC35218.1 226 NM 227
                   77 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 6.9
  Syntaxin-6_N  11 qkslnkaeslyrrwerlledt 31 
                   q+s+  +++ ++++++++++ 
    EFC35218.1 279 QNSILLLNTQFSNYTNIQTLH 299
                   778888888899998887764 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   6.5    0.0032       4.8       5      87 ..       8      95 ..       4     101 .. 0.56
   2 ?    6.2   2.1    0.0035       5.2       2      85 ..     103     185 ..     102     186 .. 0.83
   3 ?    7.7   6.8    0.0012       1.8       3      98 ..     160     251 ..     158     305 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0032
       TMPIT  5 eelekefkeleetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksvk.......eeeeeeveelkeelkerkkvlkeves 87
                +el++++ +l+ ++ e   k++e++   s+  k+i++  ++ ++l+++lk+ ++  +        + ++++++lk+el++++k+++e++ 
  EFC35218.1  8 DELKDKISQLRIQHLEKLLKVNEYN--LSEQEKTIRTLCEKNESLENQLKEASRIPNvkqvvriPKASQTIHSLKKELNRIEKQISEMST 95
                5666666666666533333333322..22222223333333333333333333222233456689999*******************986 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0035
       TMPIT   2 eeweelekefkeleeta.keykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelkerkkvlkev 85 
                 +e+++l +e +++e+   ++y  kl+e  + + ++ +ei++ ++ l+e + +++ +++   ++ + + ++l ++l+e+k  ++++
  EFC35218.1 103 KELNQLLEERNRIEDLIfENYSGKLDEFDNDKRELINEIERVENSLREHEVNFECFQNV--NKLKLKKKDLFKSLAEIKDKIEDI 185
                 6788999999999996549*********************************9999876..455556677777777777777776 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0012
       TMPIT   3 eweelekefkeleetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelkerkkvlkevesllpkknglylk 98 
                 ++++l+ + k+l ++  e+k k+e+++  ++++  eik+qk++     +++++l+k++    ++ ++el+++ ++++++ +++ +l+pk   + ++
  EFC35218.1 160 NVNKLKLKKKDLFKSLAEIKDKIEDIEYAKDTLIFEIKTQKRNKIGKVEEIERLEKKL----SDMIQELSNMHERKSEIQNDLMELIPKFPEIIIE 251
                 67888889999999999***********************9999999999***99986....4566666666555555555666666665555444 PP

>> Mod_r  Modifier of rudimentary (Mod(r)) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   8.5     0.097   1.4e+02      18      88 ..      22      94 ..       3     100 .. 0.53
   2 ?    3.4   2.5     0.051        76       6      51 ..     103     150 ..      98     165 .. 0.80
   3 ?   12.2   5.7   9.7e-05      0.15      12      92 ..     166     246 ..     159     253 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.097
       Mod_r 18 lealvktlpevkqlkeekeellaeneslaeknlslep......eleelrs..elqekleelkelekefeekeqeldell 88
                le+l      +k  + +++e +++++ l ekn sle+      ++ ++++  ++ ++ +++++l+ke+++ e++ +e++
  EFC35218.1 22 LEKL------LKVNEYNLSEQEKTIRTLCEKNESLENqlkeasRIPNVKQvvRIPKASQTIHSLKKELNRIEKQISEMS 94
                3333......333344555555666666666666655222222555555511344555668888888888887777765 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.051
       Mod_r   6 eeLqelledeeklealvktl..pevkqlkeekeellaeneslaeknls 51 
                 +eL++lle+   +e l+ +    ++++ +++k el++e+e++ ++  +
  EFC35218.1 103 KELNQLLEERNRIEDLIFENysGKLDEFDNDKRELINEIERVENSLRE 150
                 79***********9999855346699************9998655444 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 9.7e-05
       Mod_r  12 ledeeklealvktlpevkqlkeekeellaeneslaeknlslepeleelrselqekleelkelekefeekeqeldellqkfs 92 
                 l++++++++l++  +++++++ +k+ l+ e++   ++++ + +e+e l ++l++ ++el +++++  e +++l el+ kf 
  EFC35218.1 166 LKKKDLFKSLAEIKDKIEDIEYAKDTLIFEIKTQKRNKIGKVEEIERLEKKLSDMIQELSNMHERKSEIQNDLMELIPKFP 246
                 78899******766**********************************************************999998875 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   1.9       0.7   1.1e+03      70      92 ..      34      56 ..       2      64 .. 0.46
   2 ?    6.1   1.9    0.0083        12      42      75 ..      73     111 ..      67     119 .. 0.56
   3 ?    8.3   0.9    0.0018       2.6      43      97 ..     103     155 ..      98     160 .. 0.79
   4 ?    3.7   4.7     0.048        72      59     100 ..     144     185 ..     126     192 .. 0.70
   5 ?    8.5   3.4    0.0015       2.2      17     101 ..     197     242 ..     188     254 .. 0.52

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.7
                  CCCCCCCHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N 70 eeliaevkelkeelkaleaelke 92
                  +e  + +++l e+ + le++lke
    EFC35218.1 34 SEQEKTIRTLCEKNESLENQLKE 56
                  33333333333333333333333 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0083
                   HHHHHHHHHHHHHHHHHCCCCCCTT.....S-TCCCCCC CS
  Seryl_tRNA_N  42 qveleelqaerNelskeIgkakkkk.....edaeeliae 75 
                    +++ +l++e N++ k+I++++  +     ++ ++l++e
    EFC35218.1  73 SQTIHSLKKELNRIEKQISEMSTCGkniefKELNQLLEE 111
                   455667777777777777777766633333333333333 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0018
                   HHHHHHHHHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  43 veleelqaerNelskeIgkakkkkedaeeliaevkelkeelkaleaelkeleael 97 
                   +el++l +erN++   I +    k   +e  ++ +el +e++++e+ l+e e ++
    EFC35218.1 103 KELNQLLEERNRIEDLIFENYSGK--LDEFDNDKRELINEIERVENSLREHEVNF 155
                   5899*****************866..67777777777777777777777766655 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.048
                   CCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  59 Igkakkkkedaeeliaevkelkeelkaleaelkeleaelekl 100
                   +++  +++e   e+ + v++lk + k+l + l+e+++++e++
    EFC35218.1 144 VENSLREHEVNFECFQNVNKLKLKKKDLFKSLAEIKDKIEDI 185
                   344444557778888999999999999999999999999876 PP

  == domain 5  score: 8.5 bits;  conditional E-value: 0.0015
                   HHCCCTCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  17 klkkRgedkadvdelleldekrrelqveleelqaerNelskeIgkakkkkedaeeliaevkelkeelkaleaelkeleaelekll 101
                   k +kR +   +v+e+  l++k   +++el ++ +++ e+++                                         +l+
    EFC35218.1 197 KTQKR-NKIGKVEEIERLEKKLSDMIQELSNMHERKSEIQNDL--------------------------------------MELI 242
                   33344.3445555555555555555555555555555554444......................................3333 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   4.3      0.52   7.8e+02      49     121 ..       6      87 ..       2      89 .. 0.49
   2 ?    3.0   2.9     0.066        99      64     120 ..      43     100 ..      33     120 .. 0.52
   3 ?   10.6   1.1   0.00029      0.43      55     115 ..     128     187 ..     118     193 .. 0.87
   4 ?    4.3   1.7     0.026        39      67      97 ..     209     239 ..     188     254 .. 0.48

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.52
     DUF1664  49 qleqvseslaatk.rhLssridrvdkkldeqkeiskeikeevtevredlseige..dvesv......keaveglesklerie 121
                  l+++++++++ + +hL++ ++  + +l eq+++++ + e+ ++++++l+e ++  +v++v      ++++++l+++l+rie
  EFC35218.1   6 TLDELKDKISQLRiQHLEKLLKVNEYNLSEQEKTIRTLCEKNESLENQLKEASRipNVKQVvripkaSQTIHSLKKELNRIE 87 
                 4666666666666345555555555566666666666666666666555554331112222111111445555666666665 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.066
     DUF1664  64 Lssridrvdkkldeqkeiskeik.eevtevredlseigedvesvkeavegleskleri 120
                 L ++ ++++++l+e ++i +  +   + ++++ +++++++++ +++ ++++ +  ++i
  EFC35218.1  43 LCEKNESLENQLKEASRIPNVKQvVRIPKASQTIHSLKKELNRIEKQISEMSTCGKNI 100
                 4444455555555554443322212344455555555555555555555554433333 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00029
     DUF1664  55 eslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeavegles 115
                 ++  + kr+L ++i+rv+++l e  e+  e  ++v++++ + +++ + + ++k+ +e++e 
  EFC35218.1 128 DEFDNDKRELINEIERVENSLREH-EVNFECFQNVNKLKLKKKDLFKSLAEIKDKIEDIEY 187
                 566789***************986.677778889*****************9999999875 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.026
     DUF1664  67 ridrvdkkldeqkeiskeikeevtevredls 97 
                 +i+r++kkl ++++  ++++e  +e+++dl 
  EFC35218.1 209 EIERLEKKLSDMIQELSNMHERKSEIQNDLM 239
                 3333333333333333333333333333332 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.89   1.3e+03      16      29 ..       4      17 ..       2      28 .. 0.56
   2 ?    6.8   1.8    0.0069        10      11      52 ..      18      59 ..      10      70 .. 0.84
   3 ?    4.2   0.1     0.045        67      30      51 ..      73      94 ..      67     111 .. 0.72
   4 ?    5.8   1.3     0.014        21      31      56 ..     208     233 ..     178     243 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.89
                HHHHHHHHHHHHHH CS
        SlyX 16 edtieeLndvvaeq 29
                e t++eL d + + 
  EFC35218.1  4 EYTLDELKDKISQL 17
                56666666666543 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0069
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXX CS
        SlyX 11 klafqedtieeLndvvaeqqqqidrlqrqlrllaerlkelee 52
                ++ ++e++++     + eq+++i  l ++ + l+++lke++ 
  EFC35218.1 18 RIQHLEKLLKVNEYNLSEQEKTIRTLCEKNESLENQLKEASR 59
                778888888888888999999999999999999999998875 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.045
                HHHHHHHHHHHHHHHHT-XXXX CS
        SlyX 30 qqqidrlqrqlrllaerlkele 51
                 q+i  l+++l++++++++e++
  EFC35218.1 73 SQTIHSLKKELNRIEKQISEMS 94
                4566666666666666666655 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.014
                 HHHHHHHHHHHHHHHT-XXXXXXXXX CS
        SlyX  31 qqidrlqrqlrllaerlkeleessga 56 
                 ++i+rl+++l  + ++l+++ e++++
  EFC35218.1 208 EEIERLEKKLSDMIQELSNMHERKSE 233
                 799**************999998764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (314 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2557  (0.142618); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        34  (0.00189637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.89u 0.36s 00:00:01.25 Elapsed: 00:00:00.55
# Mc/sec: 1721.98
//
Query:       EFC35219.1  [L=101]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.9e-18   67.2   0.0    2.2e-18   67.0   0.0    1.0  1  CPSF100_C  Cleavage and polyadenylation factor 2 C-terminal
  ------ inclusion threshold ------
       0.14   11.9   0.0       0.23   11.3   0.0    1.3  1  STN        Secretin and TonB N terminus short domain


Domain annotation for each model (and alignments):
>> CPSF100_C  Cleavage and polyadenylation factor 2 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.0   0.0   2.4e-22   2.2e-18      95     168 ..      25      96 ..      10      98 .. 0.90

  Alignments for each domain:
  == domain 1  score: 67.0 bits;  conditional E-value: 2.4e-22
   CPSF100_C  95 asvrsaaqplfvGdlrLadLkkallssgikAEFrgeGtLvidgaVaVrKsak.GrieiegvvletfyeVrkaiYe 168
                     + + ++ +Gdl+L+++ k+l++sg++AEF+  G+Lv+++ V+++K +k G+i++ g++++t+++Vr+++Y+
  EFC35219.1  25 P---KGHPTMLIGDLKLNQFFKLLKESGLSAEFQQGGVLVCNDEVMLQKDKKsGEIQVFGSLSPTYFQVRELLYK 96 
                 3...3789*****************************************9877*********************8 PP

>> STN  Secretin and TonB N terminus short domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   2.6e-05      0.23      31      48 ..      43      61 ..      36      61 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.6e-05
         STN 31 eLLkgtgLqyki.tgntir 48
                +LLk++gL++++ +g++++
  EFC35219.1 43 KLLKESGLSAEFqQGGVLV 61
                69**********8888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (101 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       358  (0.0199677); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.30s 00:00:00.76 Elapsed: 00:00:00.50
# Mc/sec: 613.02
//
Query:       EFC35220.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00016   21.9   8.3    0.00016   21.9   8.3    2.4  2  UPF0242          Uncharacterised protein family (UPF0242) N-t
    0.00031   20.2  11.7     0.0079   15.6   3.1    2.3  2  Tropomyosin      Tropomyosin
     0.0011   19.0  13.3     0.0085   16.1   6.2    2.7  2  Baculo_PEP_C     Baculovirus polyhedron envelope protein, PEP
     0.0036   16.9  14.9     0.0036   16.9  14.9    2.3  2  Leu_zip          Leucine zipper
     0.0047   16.8   3.0      0.012   15.5   1.7    2.1  1  Apolipoprotein   Apolipoprotein A1/A4/E domain
     0.0051   16.8  14.7       0.15   12.0   2.0    4.4  4  Prefoldin_2      Prefoldin subunit
  ------ inclusion threshold ------
       0.01   16.2  20.6       0.37   11.2   2.2    4.8  4  FlaC_arch        Flagella accessory protein C (FlaC)
      0.012   15.9   8.2      0.021   15.1   1.9    3.0  2  TSC22            TSC-22/dip/bun family
      0.013   15.4   4.6      0.013   15.4   4.6    2.4  2  STAT_alpha       STAT protein, all-alpha domain
      0.019   14.6   3.5       0.56    9.9   0.2    2.6  2  TEX13            Testis-expressed sequence 13 protein family
      0.032   14.3   6.9       0.12   12.5   5.2    2.6  2  Mei5_like        Putative double-strand recombination repair-
      0.032   14.3   3.6      0.032   14.3   3.6    4.0  3  bZIP_1           bZIP transcription factor
      0.033   14.3  14.1       0.72    9.9   3.4    3.0  2  TPR_MLP1_2       TPR/MLP1/MLP2-like protein
      0.045   13.9  16.6       0.12   12.5   7.4    3.2  3  Fib_alpha        Fibrinogen alpha/beta chain family
      0.047   14.0   5.1      0.055   13.8   3.7    1.8  1  E2R135           Coiled-coil receptor-binding R-domain of col
       0.06   13.4  15.2       0.87    9.6   4.5    3.4  3  DUF1664          Protein of unknown function (DUF1664)
      0.061   13.3   8.4        2.3    8.3   1.0    3.7  3  DUF2205          Short coiled-coil protein
      0.076   12.4   3.4       0.16   11.3   3.3    1.5  1  DUF4407          Domain of unknown function (DUF4407)
      0.083   12.7  13.0       0.73    9.7   1.6    4.2  4  Nsp1_C           Nsp1-like C-terminal region
      0.091   13.0   9.7       0.46   10.8   0.4    3.6  3  DUF948           Bacterial protein of unknown function (DUF94
       0.13   12.2   8.1         16    5.5   0.5    3.9  4  GIT_CC           GIT coiled-coil Rho guanine nucleotide excha
       0.13   12.9   1.5         11    6.8   0.0    3.2  2  SlyX             SlyX
       0.14   12.2  22.2        2.6    8.0  12.1    2.9  2  DUF1640          Protein of unknown function (DUF1640)
       0.15   11.9   8.5       0.29   11.0   0.5    3.6  3  DASH_Dam1        DASH complex subunit Dam1
       0.15   12.6  16.9        5.4    7.6   3.0    3.2  2  DUF16            Protein of unknown function DUF16
       0.15   12.3   4.2        0.3   11.3   0.2    2.7  2  MRPL52           Mitoribosomal protein mL52
       0.16    9.9  16.4          1    7.2   3.4    1.8  2  Prominin         Prominin
       0.21   11.8   5.7          1    9.6   0.5    2.7  2  DUF5446          Family of unknown function (DUF5446)
       0.22   12.0  14.3        3.4    8.1   0.2    4.7  3  LPP              Lipoprotein leucine-zipper
       0.29   11.6   1.3        1.7    9.1   0.5    2.2  2  PLAC9            Placenta-specific protein 9
       0.29   10.9   9.8        1.2    8.9   0.8    3.5  4  DivIC            Septum formation initiator
       0.35   11.2   4.6       0.88    9.9   1.2    3.1  2  DUF4164          Domain of unknown function (DUF4164)
       0.35   11.5  12.5        0.7   10.5   1.8    4.0  3  DUF5344          Family of unknown function (DUF5344)
       0.37   10.7  11.6        1.2    9.1   1.1    3.7  3  Prefoldin        Prefoldin subunit
       0.51   10.9  16.6        4.2    8.0   2.3    4.2  3  Syntaxin-6_N     Syntaxin 6, N-terminal
       0.58   10.8  19.1        2.7    8.7   2.9    3.9  4  YabA             Initiation control protein YabA
       0.62   10.4  14.6        1.8    8.9   0.6    3.6  3  BLOC1_2          Biogenesis of lysosome-related organelles co
       0.78   10.2  12.1        1.7    9.2   2.4    2.9  2  ZapB             Cell division protein ZapB
        0.9   10.1  16.4        2.4    8.7   2.8    2.9  2  APG6_N           Apg6 coiled-coil region
       0.95    9.5  15.7        1.4    9.0  10.8    2.9  2  ApoLp-III        Apolipophorin-III precursor (apoLp-III)
          1    9.4   8.2        1.7    8.6   7.1    2.1  1  GerPC            Spore germination protein GerPC
        1.3    9.1   6.0         16    5.7   0.3    3.3  3  YojJ             Bacterial membrane-spanning protein N-termin
        1.4    9.3   9.0        3.3    8.1   2.0    2.5  2  YlqD             YlqD protein
        1.8    8.9  14.8        1.5    9.1   7.2    2.9  2  DUF5082          Domain of unknown function (DUF5082)
        1.8    6.4  13.3        2.1    6.2   1.9    2.1  2  V_ATPase_I       V-type ATPase 116kDa subunit family
        1.8    8.9   8.1        8.7    6.7   4.7    2.3  2  PMEI             Plant invertase/pectin methylesterase inhibi
        1.9    8.9  16.9        2.1    8.8   4.1    2.3  2  Fez1             Fez1
        1.9    9.1   8.4         53    4.4   8.4    3.0  1  YtxH             YtxH-like protein
        2.2    8.8   6.4       0.98    9.9   0.3    3.0  2  DUF3644          Protein of unknown function (DUF3644)
        2.3    8.4  18.1        0.4   10.8   1.9    3.4  3  COG5             Golgi transport complex subunit 5
        3.5    7.9  19.0        8.3    6.7   2.0    4.5  4  XhlA             Haemolysin XhlA
        3.6    7.2  25.4    1.1e+02    2.4  24.9    2.7  1  SHE3             SWI5-dependent HO expression protein 3
        3.8    7.5  21.3        1.9    8.5   8.5    3.0  3  Laminin_II       Laminin Domain II
        4.9    7.8  11.9        7.7    7.2   2.0    3.4  3  BST2             Bone marrow stromal antigen 2
        6.5    6.9  11.0          5    7.3   1.0    3.3  3  Swi5             Swi5
        6.9    7.1  17.8        6.9    7.1  11.0    2.8  3  Uso1_p115_C      Uso1 / p115 like vesicle tethering protein, 
        7.3    6.4  19.6         17    5.2  10.5    3.1  2  Bacillus_HBL     Bacillus haemolytic enterotoxin (HBL)
        8.5    6.8  14.0         18    5.8   4.8    2.7  2  DUF4600          Domain of unknown function (DUF4600)


Domain annotation for each model (and alignments):
>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   8.3     5e-07   0.00016      82     189 ..     138     252 ..     108     258 .. 0.78
   2 ?   -0.1   0.3       2.7   8.5e+02      69      85 ..     287     303 ..     253     346 .. 0.41

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 5e-07
     UPF0242  82 eglktkeealeelqeeeeeLkeeldakeeelerlkeenq......qLqekleaiaedfeelkleleeqLaekqellqeyqetieeqrsvlekrqdqieq 174
                  +l+  e+ ++ l++  + L+ee +a +++le+l +++       q+++k+ ++ +d +++k +++ +L++   ++++++ ++++  + ++k ++ i+ 
  EFC35220.1 138 SSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDfkndmnQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKS 236
                 45666666777777777777777777777776666555555555599999999999******************************************* PP

     UPF0242 175 LeskVr.DlnyEiktL 189
                    kV+ D + Eik L
  EFC35220.1 237 AVEKVKsDFSSEIKSL 252
                 9999955*******98 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 2.7
     UPF0242  69 kleekeaklteldeglk 85 
                  ++++++ l++  +g++
  EFC35220.1 287 SISSQIQALQKSIDGVN 303
                 12222222222222333 PP

>> Tropomyosin  Tropomyosin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   3.1   2.6e-05    0.0079     104     165 ..     115     176 ..     109     195 .. 0.89
   2 !    9.5   1.4    0.0018      0.57       2      71 ..     212     282 ..     208     304 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.6e-05
  Tropomyosin 104 akeiaeeadrkyeEvarklvvvesdLeraeeraeaaeskiveLeeeLkvvgnnlksLevsee 165
                   ke+ +e+++k + v  k   ++s Le  e+r+++ es +++Leee    + nl +L+ +e+
   EFC35220.1 115 VKELIQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKED 176
                  5788899**************************************************98776 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.0018
  Tropomyosin   2 klkqveeeldeaeerlekakkkleeaekk.aekaeaEvaalnrriqlleeelerteerleealekLeeaek 71 
                  ++k +++ + +++e+ +k+k+++++a +k + +  +E  +l+  ++l  +++e   +r +  l+kL++   
   EFC35220.1 212 RMKHLNDSMTDINENINKLKESIKSAVEKvKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRS 282
                  79999999999999999999999988665155668999999999999999999999999999999887655 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   7.9    0.0069       2.1      26     115 ..     141     234 ..      97     235 .. 0.78
   2 !   16.1   6.2   2.8e-05    0.0085       3     123 ..     180     303 ..     179     320 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0069
  Baculo_PEP_C  26 rlqnvqilaqlatlldaietqLnalsedlksllaeldt.....rldtlltnLtdalnalqdtlrneLtnlnsiltnLlssvtNinstLnnllqal 115
                    +++  +   l++ ++++e++ +al+++l++l+++ d      +++  +tn+ + l  ++  ++ eL+n  s +  L+ s+t in+ +n l +++
    EFC35220.1 141 EMLEKRV-KTLESCVKSLEEENSALKSNLEKLVNKEDFkndmnQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESI 234
                   4445555.67888888888888888888888887544355666777788888889999999****************************996665 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 2.8e-05
  Baculo_PEP_C   3 dvqqLnggggnqfldLtn...vLn.airlqnvqilaqlatlldaietqLnalsedlksllaeldtrldtlltnLtdalnalqdtlrneLtnlnsilt 95 
                   d++q+n+ ++n   dL++    ++  +++  + +   l+  +++i++++n+l+e++ks+++++++++++ ++ L++ l   ++++++ L+  + +l+
    EFC35220.1 180 DMNQVNIKTTNVGKDLSDfksFMDgELKNNGSRM-KHLNDSMTDINENINKLKESIKSAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLN 275
                   6778866666666666551114542354444555.88999999999999999999999999999999999999999998777999999999999999 PP

  Baculo_PEP_C  96 nLlssvtNinstLnnllqalnnldlgal 123
                    L  +    + ++++ +qal+  + g  
    EFC35220.1 276 KLKKDRSDSEFSISSQIQALQKSIDGVN 303
                   9998888888888888888776543333 PP

>> Leu_zip  Leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9  14.9   1.2e-05    0.0036     142     248 ..     140     246 ..     101     267 .. 0.87
   2 ?    1.2   4.5      0.72   2.2e+02     165     217 ..     233     287 ..     224     318 .. 0.42

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 1.2e-05
     Leu_zip 142 nekLkerlkelEkqatsaleeksklekalkelqkelgekkdekenskeiskleeklaelkldlektleektasaksleedlastkhelLkvqeqLelae 240
                  e L++r+k+lE+ ++s+ ee+s+l+++l++l ++ + k+d+++ + +++++ + l+++k+ ++ +l+++ ++ k+l++ +++  +++ k++e ++ a 
  EFC35220.1 140 LEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAV 238
                 46799***************************999999999999***************************************************9998 PP

     Leu_zip 241 keLekkfq 248
                 + ++  f+
  EFC35220.1 239 EKVKSDFS 246
                 77766665 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.72
     Leu_zip 165 klekalkelqkelgekkdeke..nskeiskleeklaelkldlektleektasaks 217
                  +++a+++++++ +++ ++ +   s + +++e+ l+ +k+dl+k ++++++s+ s
  EFC35220.1 233 SIKSAVEKVKSDFSSEIKSLHsdLSLKKKDVETLLNRFKMDLNKLKKDRSDSEFS 287
                 2222222222222222111110111222333333344444444433333333333 PP

>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   1.7   3.9e-05     0.012      67     181 ..     156     274 ..     138     283 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 3.9e-05
                     HHHHHHHHCCHHHHHHHH..HHHHCHHCCHHCHCCHCHH...HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH-----..-----SSSHH CS
  Apolipoprotein  67 nleelrqrlapyteelre..rlaadaeelqeqlavyaee...lrerlerhvealkarlapyveelrqklaerleelkeslaphaeeveerlssrv 156
                     +lee ++ l++ +e+l +    + d++++  + + ++++   +++ ++ ++++  +r++ + +++ + + e++  lkes++ ++e+v++ +ss++
      EFC35220.1 156 SLEEENSALKSNLEKLVNkeDFKNDMNQVNIKTTNVGKDlsdFKSFMDGELKNNGSRMKHLNDSMTD-INENINKLKESIKSAVEKVKSDFSSEI 249
                     5666666666666666554455555555555555555553333334444455556666667777776.999999999999999999999999999 PP

                     HHHHHTS-TTSHHHHHS--XXXXXX CS
  Apolipoprotein 157 eelrekleeqaeelrerleanleel 181
                     + l   l+ + ++++  l++++ +l
      EFC35220.1 250 KSLHSDLSLKKKDVETLLNRFKMDL 274
                     9999999999999999999887766 PP

>> Prefoldin_2  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.0   2.0   0.00049      0.15      71     105 ..     140     174 ..     133     175 .. 0.81
   2 !    7.8   0.1    0.0099         3      67     103 ..     202     238 ..     184     241 .. 0.75
   3 ?    3.3   2.1      0.26        79      60      95 ..     231     266 ..     231     281 .. 0.68
   4 ?    1.2   0.8       1.1   3.5e+02      56      85 ..     270     299 ..     259     305 .. 0.65

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00049
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCTS- CS
  Prefoldin_2  71 ketlekeiktlekqleklekeleelkeelqkklqq 105
                  +e lek++ktle+  ++le+e + lk++l k++ +
   EFC35220.1 140 LEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNK 174
                  67888999999999999999999999998888765 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0099
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCT CS
  Prefoldin_2  67 Leerketlekeiktlekqleklekeleelkeelqkkl 103
                   + ++++   ++k l+++++++++++++lke++++++
   EFC35220.1 202 MDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAV 238
                  5555666667889999999999999999999998876 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.26
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2  60 keevkeeLeerketlekeiktlekqleklekeleel 95 
                  ke++k+ +e+ k + + eik+l + l+ ++k++e l
   EFC35220.1 231 KESIKSAVEKVKSDFSSEIKSLHSDLSLKKKDVETL 266
                  678999999999999999999988766555555443 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 1.1
                  EEE-HHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2  56 vkqdkeevkeeLeerketlekeiktlekql 85 
                  +k+d++++k++  +++ +++ +i++l+k++
   EFC35220.1 270 FKMDLNKLKKDRSDSEFSISSQIQALQKSI 299
                  456666666666666666666666666665 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   2.2    0.0012      0.37       3      33 ..     141     171 ..     140     179 .. 0.92
   2 ?    9.7   1.7    0.0035       1.1       6      39 ..     203     236 ..     200     242 .. 0.90
   3 ?    2.8   0.2       0.5   1.5e+02       7      38 ..     240     271 ..     235     275 .. 0.82
   4 ?    4.5   0.7      0.15        46       3      37 ..     261     299 ..     259     306 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.0012
   FlaC_arch   3 delEnklsklsteletvkkeneelsksveel 33 
                 + lE++++ l++ ++++++en+ l++++e+l
  EFC35220.1 141 EMLEKRVKTLESCVKSLEEENSALKSNLEKL 171
                 569**************************98 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0035
   FlaC_arch   6 EnklsklsteletvkkeneelsksveelkenVkd 39 
                 + +l++  ++++ + +++ ++++++++lke++k 
  EFC35220.1 203 DGELKNNGSRMKHLNDSMTDINENINKLKESIKS 236
                 56899999***********************986 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.5
   FlaC_arch   7 nklsklsteletvkkeneelsksveelkenVk 38 
                 +  s++s+e++++ ++++  +k+ve+l  ++k
  EFC35220.1 240 KVKSDFSSEIKSLHSDLSLKKKDVETLLNRFK 271
                 55578899****************99977776 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.15
   FlaC_arch   3 delEnklsklsteletvkkenee....lsksveelkenV 37 
                 +++E+ l+++++ l+ +kk+ ++    +s++++ l++++
  EFC35220.1 261 KDVETLLNRFKMDLNKLKKDRSDsefsISSQIQALQKSI 299
                 678999999999999999988753333677777777766 PP

>> TSC22  TSC-22/dip/bun family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   1.9   6.9e-05     0.021      10      45 ..     134     169 ..     132     178 .. 0.90
   2 ?    3.6   0.1      0.28        85      11      31 ..     222     242 ..     214     267 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 6.9e-05
       TSC22  10 fAVrEeVevLkekIkeLeernseleeENslLkalas 45 
                 +A++   e+L +++k Le+ ++ leeENs Lk+++ 
  EFC35220.1 134 LATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLE 169
                 4889999*************************9864 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.28
       TSC22  11 AVrEeVevLkekIkeLeerns 31 
                  ++E ++ Lke Ik  +e+++
  EFC35220.1 222 DINENINKLKESIKSAVEKVK 242
                 5799*********99888875 PP

>> STAT_alpha  STAT protein, all-alpha domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   4.6   4.2e-05     0.013       3      92 ..     142     255 ..     140     260 .. 0.86
   2 ?    7.2   2.7     0.014       4.4       2      87 ..     214     296 ..     213     318 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 4.2e-05
  STAT_alpha   3 eieqrleelrskvqeteqdirkLedeq......eeFdfqyqelqkl.................eqeraesekkelkkqkellqqmlnaLdqkRkelvdk 78 
                  +e+r+++l+s+v+ +e++ + L+++       e+F+ ++++++ +                 e +++ s +k+l+  ++ +++ +n+L+++ k+ v+k
  EFC35220.1 142 MLEKRVKTLESCVKSLEEENSALKSNLeklvnkEDFKNDMNQVNIKttnvgkdlsdfksfmdgELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEK 240
                 6899*******************9999677777777777777777799**************9999999****************************** PP

  STAT_alpha  79 lkell.nlleslqek 92 
                 +k  + ++++sl++ 
  EFC35220.1 241 VKSDFsSEIKSLHSD 255
                 986551466666665 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.014
  STAT_alpha   2 qeieqrleelrskvqeteqdirk.LedeqeeFdfqyqelqkleqeraesekkelkkqkellqqmlnaLdqkRkelvdklkellnlle 87 
                 ++++++++++++++++++++i++ +e++  +F+ ++++l++      + +kk ++   + ++  ln+L++ R +    ++  ++ l+
  EFC35220.1 214 KHLNDSMTDINENINKLKESIKSaVEKVKSDFSSEIKSLHSD----LSLKKKDVETLLNRFKMDLNKLKKDRSDSEFSISSQIQALQ 296
                 678999999**********99976889999999999999988....44444445555555555555555555444333333333333 PP

>> TEX13  Testis-expressed sequence 13 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.2    0.0018      0.56      82     126 ..     143     187 ..     112     204 .. 0.79
   2 ?    5.2   0.3      0.05        15      84     139 ..     225     281 ..     207     305 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0018
       TEX13  82 qarrvqkLqdqveehksaaqaLaselkrlreqqemerkeaasqlq 126
                  ++rv+ L+  v+  +   +aL s+l++l ++++  ++  +++++
  EFC35220.1 143 LEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMNQVNIK 187
                 579****************************87765554444443 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.05
       TEX13  84 rrvqkLqdqvee.hksaaqaLaselkrlreqqemerkeaasqlqlaqaalaevqker 139
                 + ++kL++ ++   + + + + se+k l++     +k++++ l+  + +l++++k+r
  EFC35220.1 225 ENINKLKESIKSaVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDR 281
                 567778877765246777788888888888888888888888888888888888777 PP

>> Mei5_like  Putative double-strand recombination repair-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.2       1.2   3.8e+02      71     110 ..     140     178 ..     129     186 .. 0.70
   2 ?   12.5   5.2   0.00038      0.12      17     111 ..     170     263 ..     154     270 .. 0.73

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 1.2
   Mei5_like  71 leeliekwkevieeciiiLkkefelkakevfkafdLkkyg 110
                 le + ek  +++e+c+  L++e ++ ++++ k  + + + 
  EFC35220.1 140 LE-MLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFK 178
                 44.5666677899999999999998888776666655555 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 0.00038
   Mei5_like  17 levdekafyklkekksekkkn..rRySDqFkdplfiekdiyrKLkliekfkkknkdleeliekwkevieeciiiLkkefelkakevfkafdLkkygf 111
                 + v+++ f++ +++   k +n  +  SD Fk   f++ +       ++++++   d++e i+k ke+i+++++ +k+ f+ + k ++  + Lkk  +
  EFC35220.1 170 KLVNKEDFKNDMNQVNIKTTNvgKDLSD-FKS--FMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKVKSDFSSEIKSLHSDLSLKKKDV 263
                 4566666666666666665555566666.553..33333333334468899999***************************************9766 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   3.6    0.0001     0.032      26      54 ..     145     173 ..     139     181 .. 0.80
   2 ?    4.4   1.2      0.13        39      33      58 ..     211     236 ..     204     242 .. 0.60
   3 ?    1.2   0.4       1.3     4e+02      38      61 ..     245     268 ..     239     271 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 0.0001
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  26 aeieeLerrvkaLekeNksLkseleelkk 54 
                 ++++ Le+ vk Le+eN++Lks le+l +
  EFC35220.1 145 KRVKTLESCVKSLEEENSALKSNLEKLVN 173
                 67888888889999999999888888854 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.13
                 HHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  33 rrvkaLekeNksLkseleelkkevek 58 
                 +r+k L+  +++  + +++lk+ +++
  EFC35220.1 211 SRMKHLNDSMTDINENINKLKESIKS 236
                 45666666666666666666666554 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 1.3
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  38 LekeNksLkseleelkkevekLks 61 
                 +++e ksL s l+  kk+ve+L++
  EFC35220.1 245 FSSEIKSLHSDLSLKKKDVETLLN 268
                 788889999999999999999876 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   3.4    0.0023      0.72      69     128 ..     111     170 ..     105     171 .. 0.88
   2 ?    8.5   3.0    0.0062       1.9       9     120 ..     212     328 ..     204     331 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0023
  TPR_MLP1_2  69 lkaeiaelkaeaesakaeleeseesweeqkeelekelselekriedlneqNklLhdQlEs 128
                 l ++++el +e  +  ++++ +  + ++  e+lek+++ le+ ++ l+e N+ L + lE+
  EFC35220.1 111 LMTRVKELIQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEK 170
                 556788888888888888889999999999***************************997 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0062
  TPR_MLP1_2   9 eikslkeekeeaeaklqklqedlekqaeiake....aqqkYerelvkhaedvke.lqalreelnelkaeiaelkaeaesakaeleeseesweeqkeele 102
                  +k l+++ ++ +++++kl+e +++  e +k       ++ ++ l ++++dv++ l++++ +ln+lk+++++ + +  s  ++l++s    ++ +  + 
  EFC35220.1 212 RMKHLNDSMTDINENINKLKESIKSAVEKVKSdfssEIKSLHSDLSLKKKDVETlLNRFKMDLNKLKKDRSDSEFSISSQIQALQKSIDGVNSNEGGIS 310
                 555666666666666666666666555555431111334455666666666665246666666666666666666666666666666666666666666 PP

  TPR_MLP1_2 103 kelselekriedlneqNk 120
                 k +s++     dl+ +N+
  EFC35220.1 311 KFVSQTVDDDLDLDRKNS 328
                 666666666666666655 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   2.5      0.01       3.1      56     117 ..     113     174 ..     101     185 .. 0.75
   2 ?   12.5   7.4    0.0004      0.12      32     130 ..     142     239 ..     136     244 .. 0.83
   3 ?    4.1   0.7      0.16        50      26      83 ..     256     313 ..     251     327 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.01
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHH CS
   Fib_alpha  56 elvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesneqk 117
                 + vke+ + ++ k +  + +  ++++s ++le+++ +l+  +++ e++  +L+++le++++k
  EFC35220.1 113 TRVKELIQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNK 174
                 334444444444444444468999********************************998876 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 0.0004
                 CCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  32 dvkkdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesneqkiqkLeqdidqker 130
                  ++k++++le+ +++++++++  ++  +++ ++   k+  ++  +  ++++ k+l +  + ++ +++++ s+++ L + + + +++i+kL++ i++  +
  EFC35220.1 142 MLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMNQ-VNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVE 239
                 567899999999999999999998888888776444444444.388999999****89999999*****************************987655 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.16
                 CCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  26 llkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnvikkss 83 
                 l+ ++kdv++ l++ + +l+++++  +++e  +++  + l++     + n+  i+k+ 
  EFC35220.1 256 LSLKKKDVETLLNRFKMDLNKLKKDRSDSEFSISSQIQALQKSIDGVNSNEGGISKFV 313
                 5567889999999999999999998888877666666666666666666655555543 PP

>> E2R135  Coiled-coil receptor-binding R-domain of colicin E2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   3.7   0.00018     0.055      16     123 ..     139     243 ..     130     268 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 0.00018
      E2R135  16 eldaedkniatlnsriastekaipgaraavqeadkkvkeaeankddfvtynp.pheygsgwqdqvryldkdiqnqneklkaaqtslnemneslsrdkaa 113
                  l+  +k + tl+s + s e       +a++    k+ + e  k+d+   n    + g    d   ++d +++n+  ++k  + s+ ++ne + + k +
  EFC35220.1 139 SLEMLEKRVKTLESCVKSLEE----ENSALKSNLEKLVNKEDFKNDMNQVNIkTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKES 233
                 556667777777777776665....45667767777778888899988888515689****************************************** PP

      E2R135 114 lsgamesrkq 123
                 +  a+e  k 
  EFC35220.1 234 IKSAVEKVKS 243
                 ****998775 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.4     0.023         7      76     122 ..     113     159 ..     106     162 .. 0.90
   2 ?    9.6   4.5    0.0028      0.87      35     112 ..     173     251 ..     166     265 .. 0.66
   3 ?    8.5   5.3    0.0065         2      37     121 ..     218     303 ..     212     323 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.023
     DUF1664  76 deqkeiskeikeevtevredlseigedvesvkeavegleskleriee 122
                   +ke+++e++ + t+v  +  ++++ +e +++ v++les ++++ee
  EFC35220.1 113 TRVKELIQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEE 159
                 567899999999999999999999********************997 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0028
     DUF1664  35 TkrslsdavesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedves.vkeaveg 112
                  k  +++ +++v  + ++v ++l++ k  +  ++++ ++++++ ++  ++i+e++++++e +++  e+v+s  ++ +++
  EFC35220.1 173 NKEDFKNDMNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKVKSdFSSEIKS 251
                 5666777777777777777777777777777777777777777777777777777777776666555554323333333 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0065
     DUF1664  37 rslsdavesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedve.svkeaveglesklerie 121
                  s++d  e++ k  e+++++++++k ++ss+i+++ + l   k+  + + +  +   ++l++ ++d+e s+++ ++ l+++++ ++
  EFC35220.1 218 DSMTDINENINKLKESIKSAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSEfSISSQIQALQKSIDGVN 303
                 467777788888778888889999999*****999998876654444433333333333333333333356667777777766655 PP

>> DUF2205  Short coiled-coil protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   1.0    0.0075       2.3      27      67 ..     135     175 ..     103     183 .. 0.77
   2 ?    4.3   0.1      0.13        41      24      44 ..     212     232 ..     193     246 .. 0.82
   3 ?    3.5   0.1      0.24        74       9      33 ..     276     300 ..     267     305 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0075
     DUF2205  27 eLqssLqaLaervdeVkeehdKLesenrfLqqYIgdLmsts 67 
                 + +ssL+ L +rv    +  + Le en  L +  ++L+ + 
  EFC35220.1 135 ATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKE 175
                 45788888888888888888888888888888888887665 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.13
     DUF2205  24 qakeLqssLqaLaervdeVke 44 
                 ++k L++s+ ++ e +++ ke
  EFC35220.1 212 RMKHLNDSMTDINENINKLKE 232
                 789999999999999999887 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.24
     DUF2205   9 dveklerearerLqqqakeLqssLq 33 
                 +++k  ++    +++q+++Lq+s +
  EFC35220.1 276 KLKKDRSDSEFSISSQIQALQKSID 300
                 444555556668999*******986 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   3.3   0.00052      0.16     116     257 ..     119     281 ..     108     304 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00052
     DUF4407 116 qqeeakelkeqlaaa.........ltaelaeleaqiaalqaeidaaearldalraeaqkeldgtk..................gtgttgvaGkgpaake 187
                  qe+a++ ++   ++         l++++++le+ +++l++e +a+++ l++l ++ + + d ++                   +g    + +g ++k+
  EFC35220.1 119 IQETATKGTAVDLKHlatnsslemLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMNQvnikttnvgkdlsdfksfMDG--ELKNNGSRMKH 215
                 44444444333333366455555544444444444444444444444444444444444433333666666688999999988666..57889999999 PP

     DUF4407 188 kkaqldaaqaelaelkakldatarlaalraelaeleaerakeraasqaaaaaddGllarlea.ldrltked 257
                  ++ ++++++++++lk++++  +++++ ++  ++   e+++ +++   ++++   ll r +  l++l k++
  EFC35220.1 216 LNDSMTDINENINKLKESIK--SAVEKVKSDFSS---EIKSLHSDLSLKKKDVETLLNRFKMdLNKLKKDR 281
                 *****************955..444443333332...4444444444444444456666666666665544 PP

>> Nsp1_C  Nsp1-like C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0         1   3.1e+02      58      92 ..      49      83 ..      31      87 .. 0.73
   2 ?    9.7   1.6    0.0024      0.73      58     110 ..     118     170 ..     111     176 .. 0.84
   3 ?    2.9   0.2       0.3        91      51      87 ..     205     242 ..     199     256 .. 0.70
   4 ?    4.3   0.2      0.11        33      10      36 ..     253     279 ..     242     289 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 1
      Nsp1_C 58 kIskLysevleaeqeqnkidqeLeyiesqqdeLes 92
                +++k+     +  + +  id++L y++ ++++L+s
  EFC35220.1 49 NLKKVIMTCWKLPSPEIGIDNNLAYVSVNREDLKS 83
                5555555555556666789*************987 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0024
      Nsp1_C  58 kIskLysevleaeqeqnkidqeLeyiesqqdeLeslLdnyEkeleellskles 110
                  I++  ++  +++ +  + + +Le++e+  + Les+++++E+e ++l s+le+
  EFC35220.1 118 LIQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEK 170
                 566667777788888889999************************99988765 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.3
      Nsp1_C  51 vLvengekIskLysevleaeqeqnkidqeLe.yiesqq 87 
                  L +ng+++++L++++ +++++ nk+ ++++  +e+ +
  EFC35220.1 205 ELKNNGSRMKHLNDSMTDINENINKLKESIKsAVEKVK 242
                 46678888888888888888888888777751355555 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.11
      Nsp1_C  10 psaaslknktldelinkWtteLeeqek 36 
                  s  slk+k  + l+n+++ +L++ +k
  EFC35220.1 253 HSDLSLKKKDVETLLNRFKMDLNKLKK 279
                 45667*****************99876 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   1.7      0.23        71      24      76 ..     143     190 ..     131     200 .. 0.63
   2 ?   10.8   0.4    0.0015      0.46      23      76 ..     208     269 ..     201     278 .. 0.77
   3 ?    1.3   0.0       1.4   4.3e+02      24      54 ..     288     318 ..     285     328 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.23
      DUF948  24 lkktldeaaatieelekqvdpilkevedllakvnelledvneklekvdpltea 76 
                 l+k ++ +++ +++le++  ++  ++e+l++k      d ++ +++v+  t++
  EFC35220.1 143 LEKRVKTLESCVKSLEEENSALKSNLEKLVNKE-----DFKNDMNQVNIKTTN 190
                 567777777777777777777777777777664.....334444444444444 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.0015
      DUF948  23 klkktldeaaatieelekqvdpilkevedllakvne........lledvneklekvdpltea 76 
                 + ++ ++++++++++++++++++ + ++ +++kv+         l +d++ k ++v++l + 
  EFC35220.1 208 NNGSRMKHLNDSMTDINENINKLKESIKSAVEKVKSdfsseiksLHSDLSLKKKDVETLLNR 269
                 55677888888888888888888888888888888766666666888888888888887765 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 1.4
      DUF948  24 lkktldeaaatieelekqvdpilkevedlla 54 
                 +++ +++++++i++++++ ++i+k v ++++
  EFC35220.1 288 ISSQIQALQKSIDGVNSNEGGISKFVSQTVD 318
                 6777899999999999999999999999876 PP

>> GIT_CC  GIT coiled-coil Rho guanine nucleotide exchange factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.5     0.051        16      42      65 ..     143     166 ..     130     175 .. 0.80
   2 ?    3.8   0.2      0.17        51      25      54 ..     206     235 ..     203     244 .. 0.88
   3 ?   -1.1   0.0       5.9   1.8e+03      35      53 ..     238     256 ..     232     262 .. 0.77
   4 ?    5.1   0.0     0.067        21      41      60 ..     287     306 ..     274     311 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.051
      GIT_CC  42 lsdelrlLQskvqkLqaeNaqlrd 65 
                 l++ ++ L s v++L++eN+ l++
  EFC35220.1 143 LEKRVKTLESCVKSLEEENSALKS 166
                 567788899999999999998875 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.17
      GIT_CC  25 laaseakiqqLlkvNtslsdelrlLQskvq 54 
                 l + ++++++L  + t +++++++L ++++
  EFC35220.1 206 LKNNGSRMKHLNDSMTDINENINKLKESIK 235
                 677899*******************98886 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 5.9
      GIT_CC  35 LlkvNtslsdelrlLQskv 53 
                 + kv++  s e++ L s +
  EFC35220.1 238 VEKVKSDFSSEIKSLHSDL 256
                 6788888888888887655 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.067
      GIT_CC  41 slsdelrlLQskvqkLqaeN 60 
                 s+s +++ LQ++++  ++++
  EFC35220.1 287 SISSQIQALQKSIDGVNSNE 306
                 899**********9998876 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1      0.37   1.2e+02      33      56 ..     140     163 ..     134     181 .. 0.57
   2 ?    6.8   0.0     0.035        11      20      50 ..     214     244 ..     211     255 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.37
                 HHHHHHHHHHHHHT-XXXXXXXXX CS
        SlyX  33 idrlqrqlrllaerlkeleessga 56 
                 ++ l+++++ l+  +k+lee+++a
  EFC35220.1 140 LEMLEKRVKTLESCVKSLEEENSA 163
                 444555555555555555555443 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.035
                 HHHHHHHHHHHHHHHHHHHHHHHHHHT-XXX CS
        SlyX  20 eeLndvvaeqqqqidrlqrqlrllaerlkel 50 
                 + Lnd +++ ++ i +l++ ++  +e++k+ 
  EFC35220.1 214 KHLNDSMTDINENINKLKESIKSAVEKVKSD 244
                 68*************************9865 PP

>> DUF1640  Protein of unknown function (DUF1640)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0  12.1    0.0085       2.6      34     148 ..     114     236 ..     108     245 .. 0.72
   2 ?    7.4   2.8     0.014       4.2      85     136 ..     246     300 ..     240     305 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0085
     DUF1640  34 slekvakslvsksel.ekseylqkaalselrkevqisersefaalrseteklqrelekl..kqkLreeidklkad...irldlnleKgrireelaklea 126
                 +++++ ++ ++k +  +  ++  ++ l+ l k v+++e s +++l++e+ +l+++lekl  k+++++++++++ +   +  dl++ K+ +  el++  +
  EFC35220.1 114 RVKELIQETATKGTAvDLKHLATNSSLEMLEKRVKTLE-SCVKSLEEENSALKSNLEKLvnKEDFKNDMNQVNIKttnVGKDLSDFKSFMDGELKNNGS 211
                 55666666666665437777788888888888888875.679999*************95555699999999865211568***************999 PP

     DUF1640 127 kiqelnnk...idrevsalrteiEs 148
                 ++++ln     i++++++l+ +i s
  EFC35220.1 212 RMKHLNDSmtdINENINKLKESIKS 236
                 9988866533355566666665543 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.014
     DUF1640  85 qreleklkqkL...reeidklkadirldlnleKgrireelakleakiqelnnkid 136
                  +e++ l+++L   ++++++l + +++dln+ K++  +   +++++iq l++ id
  EFC35220.1 246 SSEIKSLHSDLslkKKDVETLLNRFKMDLNKLKKDRSDSEFSISSQIQALQKSID 300
                 5678888887755568899999999999998888888888888888998888776 PP

>> DASH_Dam1  DASH complex subunit Dam1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.5      0.19        59       8      29 ..     143     164 ..     136     185 .. 0.55
   2 ?   11.0   0.5   0.00094      0.29       4      38 ..     212     247 ..     209     253 .. 0.81
   3 ?   -0.3   0.0       3.1   9.5e+02       4      16 ..     291     303 ..     261     312 .. 0.66

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.19
   DASH_Dam1   8 LaDsletLdknledLqqihesL 29 
                 L++ ++tL++ ++ L++ + +L
  EFC35220.1 143 LEKRVKTLESCVKSLEEENSAL 164
                 4444444444444444333333 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00094
   DASH_Dam1   4 afaeLaDsletLdknledLqq.ihesLsdfNeSFas 38 
                 +++ L+Ds++++++n+++L++ i+ +++++   F+s
  EFC35220.1 212 RMKHLNDSMTDINENINKLKEsIKSAVEKVKSDFSS 247
                 799****************86266666667666666 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 3.1
   DASH_Dam1   4 afaeLaDsletLd 16 
                 +++ L++s++ ++
  EFC35220.1 291 QIQALQKSIDGVN 303
                 3333333333333 PP

>> DUF16  Protein of unknown function DUF16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   3.0     0.018       5.4      32      96 ..     136     199 ..     104     203 .. 0.74
   2 ?    7.1   9.6     0.024       7.3      23      94 ..     193     265 ..     174     336 .. 0.68

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.018
                 BHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......HHHHHHHHHHHHH CS
       DUF16  32 nkqrLkkieakvdklgeqinkleqkvekqgekikelkveqkaqgeelnkvdetleliletLqkin 96 
                 ++  L+ +e++v++l+  ++ le++ +++  ++++l ++ + ++ ++n+v+     + + L +++
  EFC35220.1 136 TNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKN-DMNQVNIKTTNVGKDLSDFK 199
                 77788888888888888888888888888888888776655554.48888777777777777665 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.024
                 HHHHHB-..BHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHH.HH.......HHHHHHHHHHH CS
       DUF16  23 kqlnefkdsnkqrLkkieakvdklgeqinkleqkvekqgekikelkveqkaq.geelnkvdetleliletLqk 94 
                 k+l +fk   + +Lk+   +++ l+ ++  ++++++k+ e ik   +++k   + e++++++ l l  + +++
  EFC35220.1 193 KDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKVKSDfSSEIKSLHSDLSLKKKDVET 265
                 7888888776666666666666555555555555555555555555555442133444333333333332222 PP

>> MRPL52  Mitoribosomal protein mL52
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.8       1.5   4.6e+02      38      84 ..     137     183 ..     132     190 .. 0.81
   2 ?   11.3   0.2   0.00097       0.3      21      76 ..     193     249 ..     187     263 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 1.5
      MRPL52  38 sgqlkrkkkqeelakkivkllsEideaeerykkkqeeeeeeeqkiie 84 
                 +  l+ ++k+ ++ ++ vk l+E ++a +   +k  ++e+ ++ + +
  EFC35220.1 137 NSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMNQ 183
                 44788899999999999999999999999999999888888877665 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00097
      MRPL52  21 tdlpDf.sfaDGRpapvtsgqlkrkkkqeelakkivkllsEideaeerykkkqeeee 76 
                 +dl+Df sf+DG     +s+ +       ++ + i+kl + i++a+e++k+  + e 
  EFC35220.1 193 KDLSDFkSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKVKSDFSSEI 249
                 58999988*****************************************98776654 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   3.4    0.0033         1     648     700 ..     121     174 ..      77     187 .. 0.82
   2 ?    6.5   7.1    0.0055       1.7     209     324 ..     189     299 ..     175     323 .. 0.50

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0033
    Prominin 648 kqslkneaqdlraiqqelvlp.lessvkklkksvkkldeensdlqesikkllaa 700
                 ++++k +a dl+++ ++  l+ le+ vk+l++ vk+l+eens l+++++kl+++
  EFC35220.1 121 ETATKGTAVDLKHLATNSSLEmLEKRVKTLESCVKSLEEENSALKSNLEKLVNK 174
                 45678899999999998876637999************************9987 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0055
    Prominin 209 khvsddLddagkhlgldladtlesnvlpaLaelerllenlkeakeqLe.qvnklekeLrksgsqLrdglrgvkrdlnqalsn.lCqseeCskilsslei 305
                 ++v +dL+d ++ + ++l+++ +    +  ++++ + en+++ ke+++ +v+k++++  ++ + L++ l+  k+d++++l+  +      +k++++ + 
  EFC35220.1 189 TNVGKDLSDFKSFMDGELKNNGSRM-KHLNDSMTDINENINKLKESIKsAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRfKMD---LNKLKKDRSD 283
                 3355555555555555555543333.333345666666666666666523556666666666666666666666666666663332...3333333322 PP

    Prominin 306 ekldtskcl.dqlpnvdevl 324
                  +      + +q++ +++ +
  EFC35220.1 284 SEFS----IsSQIQALQKSI 299
                 1111....112333333333 PP

>> DUF5446  Family of unknown function (DUF5446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.5    0.0032         1      39      68 ..     132     161 ..     110     165 .. 0.76
   2 ?    4.0   0.6      0.18        57      27      59 ..     222     254 ..     214     268 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.0032
     DUF5446  39 keekeeerldllekElkdLvlCigklekae 68 
                 k+ + +  l+ lek +k L +C+ +le  +
  EFC35220.1 132 KHLATNSSLEMLEKRVKTLESCVKSLEEEN 161
                 667899*****************9998765 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.18
     DUF5446  27 elseavneteaekeekeeerldllekElkdLvl 59 
                 +++e +n+++   +++ e++ +   +E+k L++
  EFC35220.1 222 DINENINKLKESIKSAVEKVKSDFSSEIKSLHS 254
                 467777777777778888888888888887776 PP

>> LPP  Lipoprotein leucine-zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.3      0.13        40       3      32 ..     141     170 ..     139     184 .. 0.79
   2 ?    3.0   2.6      0.45   1.4e+02      12      34 ..     216     238 ..     210     280 .. 0.69
   3 ?    8.1   0.2     0.011       3.4       5      28 ..     288     311 ..     286     321 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.13
         LPP   3 deLssqVsqLkskvdqlssdvnsakaaaqa 32 
                 ++L + V++L+s v++l+++ +++k+++++
  EFC35220.1 141 EMLEKRVKTLESCVKSLEEENSALKSNLEK 170
                 677788888888888888888888877665 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.45
         LPP  12 Lkskvdqlssdvnsakaaaqaak 34 
                 L++ +  +++++n++k+ +++a 
  EFC35220.1 216 LNDSMTDINENINKLKESIKSAV 238
                 44444444444444444444433 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.011
         LPP   5 LssqVsqLkskvdqlssdvnsaka 28 
                 +ssq+++L++ +d ++s+   +++
  EFC35220.1 288 ISSQIQALQKSIDGVNSNEGGISK 311
                 9***************99544443 PP

>> PLAC9  Placenta-specific protein 9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.5    0.0054       1.7      13      56 ..     125     172 ..     119     175 .. 0.79
   2 ?    0.3   0.0       3.2   9.8e+02      28      52 ..     232     256 ..     213     259 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0054
       PLAC9  13 rstaCd.rhlavqsrldvieetv...ektvehleaevkGllgqleela 56 
                 + ta d +hla +s l+++e  v   e  v+ le e   l + le+l 
  EFC35220.1 125 KGTAVDlKHLATNSSLEMLEKRVktlESCVKSLEEENSALKSNLEKLV 172
                 566777579*******99997543338899999999999999999985 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 3.2
       PLAC9  28 dvieetvektvehleaevkGllgql 52 
                 + i   vek    + +e+k l + l
  EFC35220.1 232 ESIKSAVEKVKSDFSSEIKSLHSDL 256
                 4566778888888889999887765 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.8     0.004       1.2      19      55 ..     140     176 ..     135     180 .. 0.87
   2 ?    5.4   0.3     0.048        15      14      48 ..     208     242 ..     206     258 .. 0.79
   3 ?   -1.6   0.0       7.7   2.4e+03      21      39 ..     251     269 ..     246     290 .. 0.50
   4 ?   -0.2   0.0       2.8   8.6e+02      22      39 ..     288     305 ..     284     320 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.004
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-XXXXX CS
       DivIC  19 ykqlkqeiaalqaelaklkaeneeLeaevkdLksded 55 
                 +  l++ +++l+  +++l +en +L++++++L + ed
  EFC35220.1 140 LEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKED 176
                 6778999*************************76665 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.048
                 XXXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
       DivIC  14 kgllaykqlkqeiaalqaelaklkaeneeLeaevk 48 
                 ++ +++k l+  +++++++++klk+ +++  ++vk
  EFC35220.1 208 NNGSRMKHLNDSMTDINENINKLKESIKSAVEKVK 242
                 66678888899999999999999998888777665 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 7.7
                 HHHHHHHHHHHHHHHHHHH CS
       DivIC  21 qlkqeiaalqaelaklkae 39 
                 +l++++  +++++++l ++
  EFC35220.1 251 SLHSDLSLKKKDVETLLNR 269
                 3444444444444444333 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 2.8
                 HHHHHHHHHHHHHHHHHH CS
       DivIC  22 lkqeiaalqaelaklkae 39 
                 + ++i+alq+ ++ ++  
  EFC35220.1 288 ISSQIQALQKSIDGVNSN 305
                 667999999998877655 PP

>> DUF4164  Domain of unknown function (DUF4164)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   1.2    0.0028      0.88      17      88 ..     168     239 ..     133     240 .. 0.69
   2 ?   -0.1   0.1       3.7   1.1e+03       8      49 ..     240     282 ..     236     297 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0028
     DUF4164  17 ldsLEkavdrrleaerkrdele.aei.ealgedrsRLaeeLdqaearaarleevnrEvsrrLkaaietiravLa 88 
                 l++L +  d +  ++ ++ +++ +++ + l + +s ++ eL +   r + l++   +++++++ + e+i+++ +
  EFC35220.1 168 LEKLVNKEDFK--NDMNQVNIKtTNVgKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVE 239
                 33332222222..222222222133457788889999*********************************9865 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 3.7
     DUF4164   8 aaltrLeaaldsLEkavdrrleaerkr.deleaeiealgedrs 49 
                 ++ ++ +  ++sL + +  + +  ++  + ++ ++++l++drs
  EFC35220.1 240 KVKSDFSSEIKSLHSDLSLKKKDVETLlNRFKMDLNKLKKDRS 282
                 5555666666666666665555544444677777777777775 PP

>> DUF5344  Family of unknown function (DUF5344)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1      0.15        46      60      85 ..     140     165 ..     133     167 .. 0.85
   2 ?   10.5   1.8    0.0023       0.7       1      78 [.     181     253 ..     181     255 .. 0.83
   3 ?    0.8   0.2       2.5   7.6e+02       6      30 ..     258     282 ..     253     305 .. 0.53

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.15
     DUF5344  60 ktlllknvedtesaVdslkeaDeala 85 
                  ++l+k v++ es V+sl+e+  al 
  EFC35220.1 140 LEMLEKRVKTLESCVKSLEEENSALK 165
                 5799****************988875 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.0023
     DUF5344   1 mgEIklnqaeVeqkLselktaaeelktsipetisgknsldvvekineleeeleellkaYktlllknvedtesaVdslk 78 
                 m++++++++ V + Ls+ k+  ++  +++ + +++       +++++++e++++l ++ k++++k+  d+ s ++sl 
  EFC35220.1 181 MNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKH-----LNDSMTDINENINKLKESIKSAVEKVKSDFSSEIKSLH 253
                 88999999999999999998877665666666666.....66889999999999999999999999999999999885 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 2.5
     DUF5344   6 lnqaeVeqkLselktaaeelktsip 30 
                 l++++Ve+ L + k  +++lk++ +
  EFC35220.1 258 LKKKDVETLLNRFKMDLNKLKKDRS 282
                 5666666666666666666643322 PP

>> Prefoldin  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   1.1    0.0037       1.2      78     111 ..     139     172 ..     134     179 .. 0.88
   2 ?    6.2   0.5     0.031       9.5      85     111 ..     212     238 ..     210     244 .. 0.76
   3 ?   -0.6   0.1       3.8   1.2e+03      84     115 ..     240     271 ..     235     276 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0037
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  78 Aiellkkkleelekqlekleeeleklkdqittle 111
                 + e l+k++++le+ +++leee   lk+++++l 
  EFC35220.1 139 SLEMLEKRVKTLESCVKSLEEENSALKSNLEKLV 172
                 6799************************999876 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.031
                 HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  85 kleelekqlekleeeleklkdqittle 111
                 ++++l++++++++e+++klk+ i+++ 
  EFC35220.1 212 RMKHLNDSMTDINENINKLKESIKSAV 238
                 678888888888888888888887664 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 3.8
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  84 kkleelekqlekleeeleklkdqittleanla 115
                 k +++ ++ +++l  +l  +k+ ++tl + + 
  EFC35220.1 240 KVKSDFSSEIKSLHSDLSLKKKDVETLLNRFK 271
                 56678888999999999999999999887665 PP

>> Syntaxin-6_N  Syntaxin 6, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1       2.5   7.9e+02      36      78 ..      25      69 ..      10      84 .. 0.71
   2 ?    8.0   2.3     0.013       4.2      19      92 ..     110     182 ..     105     190 .. 0.79
   3 ?    5.4   3.7     0.085        26      48      81 ..     218     252 ..     202     332 .. 0.61

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 2.5
  Syntaxin-6_N 36 seeldetrteLrkalrs.iewdledLeetvriveknpsk.fkide 78
                   +eld t+t +r + +s  + +le+L++++ +  k ps   +id+
    EFC35220.1 25 LSELDATKTTMRLKWDSdHKMNLENLKKVIMTCWKLPSPeIGIDN 69
                  568888888888776542788899999999777776665566665 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.013
  Syntaxin-6_N  19 slyrrwerlledtssstseeldetrteLrkalrsiewdledLeetvriveknpskfkidekelsrrrafveevr 92 
                   sl++r ++l ++t ++    +d  +   +++l+ +e+ ++ Le  v+ +e+++s  k + ++l ++++f ++++
    EFC35220.1 110 SLMTRVKELIQETATK-GTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMN 182
                   6777788777777774.444444445557899******************999999999999999999977765 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.085
  Syntaxin-6_N  48 kalrsiewdledLeetvr.iveknpskfkidekel 81 
                    ++ +i+++++ L+e+++ +vek +s+f+ + k l
    EFC35220.1 218 DSMTDINENINKLKESIKsAVEKVKSDFSSEIKSL 252
                   44444444444444444323444444443333322 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       6.5     2e+03      20      46 ..      24      50 ..      15     112 .. 0.72
   2 ?    7.4   3.9     0.022       6.7      15      56 ..     138     181 ..     107     204 .. 0.68
   3 ?    8.7   2.9    0.0087       2.7       8      61 ..     211     265 ..     202     285 .. 0.77
   4 ?    1.7   0.0       1.3   3.9e+02       6      55 ..     288     337 ..     283     351 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 6.5
                HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        YabA 20 lleeleelkeelaelleenaeLelene 46
                +l+el++ k+++    + +++++len 
  EFC35220.1 24 FLSELDATKTTMRLKWDSDHKMNLENL 50
                566777777777777777777777763 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.022
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..XXXX CS
        YabA  15 eqleelleeleelkeelaelleenaeLeleneklrerl..eeee 56 
                 ++le l +++++l++ +++l een++L+ + ekl ++   +++ 
  EFC35220.1 138 SSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEdfKNDM 181
                 45666777777777777777777777777777765554222222 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0087
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHXXXXXXXXX CS
        YabA   8 dkleeleeqleelleeleelkeelaellee.naeLeleneklrerleeeekkeke 61 
                 +++++l++++++++e++++lke++++ +e+  ++++ e ++l++ l+ ++k+ ++
  EFC35220.1 211 SRMKHLNDSMTDINENINKLKESIKSAVEKvKSDFSSEIKSLHSDLSLKKKDVET 265
                 6899**********************99983567999***999999544444433 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 1.3
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXX CS
        YabA   6 lfdkleeleeqleelleeleelkeelaelleenaeLeleneklrerleee 55 
                 + +++++l+++++ ++++ + + + ++++++++ +L   n+ +++  +++
  EFC35220.1 288 ISSQIQALQKSIDGVNSNEGGISKFVSQTVDDDLDLDRKNSLFQTPRKKS 337
                 6789999*************************999999999887766443 PP

>> BLOC1_2  Biogenesis of lysosome-related organelles complex-1 subunit 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.6    0.0059       1.8      65      94 ..     138     167 ..     112     169 .. 0.79
   2 ?    7.1   0.4     0.022       6.7       5      50 ..     196     241 ..     192     253 .. 0.73
   3 ?    1.7   0.5         1   3.2e+02      32      75 ..     256     300 ..     247     315 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0059
     BLOC1_2  65 qqidqiekqvteLeeavseLDeyskeLEak 94 
                 ++++ +ek+v++Le+ v+ L+e  ++L+++
  EFC35220.1 138 SSLEMLEKRVKTLESCVKSLEEENSALKSN 167
                 678899999999999999999988888765 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.022
     BLOC1_2   5 ekvskyleaeleatvedyklLeklNeaasekykklkdvaaslekkl 50 
                 +++++++++el+   + +k+L+   +  +e+++klk++++s+ +k+
  EFC35220.1 196 SDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKV 241
                 5667777777777777777777777777777777777777766655 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 1
     BLOC1_2  32 asekykklkdvaaslekkleklnekyeelq.pylqqidqiekqvt 75 
                  s k k++++ ++ ++ +l+kl++     + +  +qi++++k+++
  EFC35220.1 256 LSLKKKDVETLLNRFKMDLNKLKKDRSDSEfSISSQIQALQKSID 300
                 567778888888889999999888776444155678888888886 PP

>> ZapB  Cell division protein ZapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   2.4    0.0054       1.7       6      40 ..     140     174 ..     135     190 .. 0.65
   2 ?    5.2   2.3     0.095        29       4      59 ..     225     285 ..     206     297 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0054
        ZapB   6 LeqLEskiqkaidtitlLqmeieeLkeeneelkee 40 
                 Le LE++++++   +++L +e+++Lk   e+l ++
  EFC35220.1 140 LEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNK 174
                 56666666666666666666666666666555443 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.095
        ZapB   4 elLeqLEskiqkaidtitl.LqmeieeLkeeneelkeenrele....eeneqlkeereawq 59 
                 e+ ++L ++i++a++++++  + ei+ L  + +  k+  + l       +++lk++r+  +
  EFC35220.1 225 ENINKLKESIKSAVEKVKSdFSSEIKSLHSDLSLKKKDVETLLnrfkMDLNKLKKDRSDSE 285
                 7788888888888888864388888888877777777666666666677777777777655 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   4.2      0.02       6.1      48      92 ..     132     176 ..     104     191 .. 0.61
   2 ?    8.7   2.8    0.0079       2.4      38     123 ..     209     285 ..     181     299 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.02
      APG6_N  48 eleeleeeleklekeeeelleeLkelekereeleaelaaleeele 92 
                 ++ +++ +le lek  ++l++  k le+e+++l++ l++l ++++
  EFC35220.1 132 KHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKED 176
                 444455556666666666666666666666666666666665554 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0079
      APG6_N  38 ekkeeekqdeeleeleeeleklekeeeelleeLk.elekereeleaelaaleeelealeeeeerfwreynelqlelleleeeldsle 123
                 +        + +++l++++ ++++  ++l e +k ++ek +++  +e+++l++ l+ ++++ e  ++    ++++l++l++++   e
  EFC35220.1 209 N-------GSRMKHLNDSMTDINENINKLKESIKsAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLN---RFKMDLNKLKKDRSDSE 285
                 2.......35677888888888888888888887346888889999999988888888887777654...44445555444444443 PP

>> ApoLp-III  Apolipophorin-III precursor (apoLp-III)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.6       1.5   4.5e+02      94     143 ..     113     164 ..     103     167 .. 0.58
   2 ?    9.0  10.8    0.0046       1.4       7     140 ..     164     293 ..     159     299 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 1.5
   ApoLp-III  94 sgvqslvkesqklaeslkensqeakeklakaik..qayddaveaaqklakqL 143
                 ++v++l++e+++ + +++ +  +++  l+ + k  + ++  v+++++ + +L
  EFC35220.1 113 TRVKELIQETATKGTAVDLKHLATNSSLEMLEKrvKTLESCVKSLEEENSAL 164
                 5677777777766666666655555555544431134555666665555555 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0046
   ApoLp-III   7 lqksvkkqlnlpsqeevvetiKensenlvdqlkqvikslqeelkkksdeleealkevkkkieetadklseenPevkkkaqelqekvQsgvqslvkesqk 105
                 l+ +++k +n  + ++ ++ +  +++n+ + l+++ + ++ elk++ + ++  l+++ ++i+e  +kl+e    +k ++++ ++ + s ++sl ++   
  EFC35220.1 164 LKSNLEKLVNKEDFKNDMNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMK-HLNDSMTDINENINKLKE---SIKSAVEKVKSDFSSEIKSLHSDLSL 258
                 6788889999777777888899999*******************9987765.578888999999999999...78889999999999999999999999 PP

   ApoLp-III 106 laeslkensqeakeklakaikqayddaveaaqkla 140
                   ++++   +  k +l+k+ k  +d  ++ +++++
  EFC35220.1 259 KKKDVETLLNRFKMDLNKLKKDRSDSEFSISSQIQ 293
                 99999999999999999998888888777666654 PP

>> GerPC  Spore germination protein GerPC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   7.1    0.0056       1.7       2     141 ..     148     281 ..     147     315 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0056
       GerPC   2 qklekqleelqeeleelkkkpatsiekieYkFDqLKvekLeGTLNiGlnPsdlgksiedfaveqaktvapeneaeselfqeiqeeveayLeeeapelle 100
                 ++le+ +++l+ee ++lk++ ++ ++k ++k D   v+    T N+G   sd+ ks  d + +++ +   + ++ ++ +++i+e++++ L+e++++ +e
  EFC35220.1 148 KTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMNQVNI--KTTNVGKDLSDF-KSFMDGELKNNGS---RMKHLNDSMTDINENINK-LKESIKSAVE 239
                 78*******************************999985..488********9.9999999977554...45677888899***9987.999999**** PP

       GerPC 101 elekqyeveldeeyrefil..eDikkQldsRikyYlkqvaaee 141
                 ++++ +++e+ + + ++ l  +D++  l +R k  l++ ++++
  EFC35220.1 240 KVKSDFSSEIKSLHSDLSLkkKDVET-LLNRFKMDLNKLKKDR 281
                 *9999999999888776441145554.3356666666544444 PP

>> YojJ  Bacterial membrane-spanning protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.8      0.14        44      16      47 ..     141     172 ..     136     185 .. 0.88
   2 ?   -0.8   0.0       5.6   1.7e+03      19      35 ..     189     205 ..     172     225 .. 0.47
   3 ?    5.7   0.3     0.052        16       6      34 ..     226     254 ..     220     257 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.14
        YojJ  16 eeLeqiekeleevlkaldeedeClLcelesir 47 
                 e+Le+  k+le  +k+l+ee++ l ++le++ 
  EFC35220.1 141 EMLEKRVKTLESCVKSLEEENSALKSNLEKLV 172
                 68999999********************9985 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 5.6
        YojJ  19 eqiekeleevlkaldee 35 
                  ++ k+l++    +d e
  EFC35220.1 189 TNVGKDLSDFKSFMDGE 205
                 34445555555555544 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.052
        YojJ   6 leeelkeklkeeLeqiekeleevlkalde 34 
                 + ++lke +k   e+++ + +  +k+l++
  EFC35220.1 226 NINKLKESIKSAVEKVKSDFSSEIKSLHS 254
                 5689**********************997 PP

>> YlqD  YlqD protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   5.5      0.17        53       9     103 ..     131     266 ..     126     268 .. 0.72
   2 ?    8.1   2.0     0.011       3.3      23      96 ..     214     287 ..     205     323 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.17
        YlqD   9 VKaivTeklKeelq...qqlqaqieqldkelqqLefqakrlikeikkqsaq.....................................qieeiqeqvek 67 
                 +K+  T+++ e+l+   ++l++ ++ l++e + L+ ++++l+++   ++                                       +++ i+e+++k
  EFC35220.1 131 LKHLATNSSLEMLEkrvKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMnqvnikttnvgkdlsdfksfmdgelknngsrmkhlndSMTDINENINK 229
                 566666666555551114677888899999999999999998888777666678888888888888888888888888888888777777777777777 PP

        YlqD  68 ekserlekkkqllqql.eqvqkLelgsevkqgqvesl 103
                  k+ ++ + ++++++  +++++L+ +  +k++ ve+l
  EFC35220.1 230 LKESIKSAVEKVKSDFsSEIKSLHSDLSLKKKDVETL 266
                 7777777777777775247888888888888888776 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.011
        YlqD  23 qqlqaqieqldkelqqLefqakrlikeikkqsaqqieeiqeqvekekserlekkkqllqqleqvqkLelgsevk 96 
                 ++l+++++ +++++++L+   k +++++k+   ++i+++++ ++ +k++++   ++++ +l++++k   +se +
  EFC35220.1 214 KHLNDSMTDINENINKLKESIKSAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSEFS 287
                 56777777888888888888888888888777777777777777777777777777777777777766666654 PP

>> DUF5082  Domain of unknown function (DUF5082)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   7.8       0.1        31      18     113 ..     139     243 ..     132     252 .. 0.58
   2 ?    9.1   7.2    0.0048       1.5      29     119 ..     206     296 ..     203     332 .. 0.70

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.1
     DUF5082  18 eiaaleekIerLkeaktklsdekeslkqk.kkklekplnsse....sWkGk.eennydgirsnlessyqtyvdkldelida...ieeEIerLenqisea 107
                  ++ le+ ++ L++  ++l++e+++lk++ +k ++k +++++    + k +   ++ +++ s+++ + ++  ++++ l d+   i+e I++L+++i++a
  EFC35220.1 139 SLEMLEKRVKTLESCVKSLEEENSALKSNlEKLVNKEDFKNDmnqvNIKTTnVGKDLSDFKSFMDGELKNNGSRMKHLNDSmtdINENINKLKESIKSA 237
                 456677777777777777777777776541444455555555423222222244444444446776666666555555443222789999999999998 PP

     DUF5082 108 qgvldt 113
                   ++++
  EFC35220.1 238 VEKVKS 243
                 887765 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0048
     DUF5082  29 LkeaktklsdekeslkqkkkklekplnssesWkGkeennydgirsnlessyqtyvdkldelidaieeEIerLenqiseaqgvldtlqsqln 119
                 Lk   ++++  + s+ + +++++k   s +s   k +++++++  +l s+ +  ++++++l  + +++ ++L++++s+++ +++++ ++l+
  EFC35220.1 206 LKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSEFSISSQIQALQ 296
                 5555566666666777777777777777777777777777777777777777777777777777777777777777777777666655554 PP

>> V_ATPase_I  V-type ATPase 116kDa subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   3.9     0.014       4.3      47     115 ..     116     184 ..     105     200 .. 0.76
   2 ?    6.2   1.9    0.0067       2.1     243     333 ..     208     305 ..     199     321 .. 0.67

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.014
  V_ATPase_I  47 eklekavikeeeaeesleapeekeldeleeelekleeelkelnenleklkkelnelvelkavlekakef 115
                 ++l ++++++ +a++ ++ +++++l+ le+++++le+ +k+l+e++++lk++l++lv+++   + ++++
  EFC35220.1 116 KELIQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKNDMNQV 184
                 3434444444555778888899999999*************************9999998877766655 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0067
  V_ATPase_I 243 ereeklkeveeriedlekvleqteealkevleei....akeleewklkv.kkekaiyhtLnlfnldvtk..kvliaegWvpkeeleeiqkalkeatee 333
                 +  +++k+++++++d+++ +++ +e++k+ +e++    ++e+++++  +  k+k + + Ln f++d +k  k    + +  +++++++qk+++ ++++
  EFC35220.1 208 NNGSRMKHLNDSMTDINENINKLKESIKSAVEKVksdfSSEIKSLHSDLsLKKKDVETLLNRFKMDLNKlkKDRSDSEFSISSQIQALQKSIDGVNSN 305
                 45567788888888888888888888888888876666777777766551588889999999998765311444555566666666666666666544 PP

>> PMEI  Plant invertase/pectin methylesterase inhibitor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   1.5     0.059        18      49     103 ..     126     183 ..      97     194 .. 0.58
   2 ?    6.7   4.7     0.028       8.7      15     126 ..     152     278 ..     151     305 .. 0.64

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.059
                 HHHHHHHHHHHHS......-.HH..HHHHHHHHHHHHHHHHHHHHHHHHH..-HH.....H CS
        PMEI  49 saaaaiskllkkskkkklkk.kk..aaledClelyedavdeLedalaalk..rskrk.vdd 103
                  +a  +++l ++s+ +   + +k  + le+C++ +e+  ++L++ l++l   ++++  +++
  EFC35220.1 126 GTAVDLKHLATNSSLE---MlEKrvKTLESCVKSLEEENSALKSNLEKLVnkEDFKNdMNQ 183
                 2233444443322222...2122457999***99999999999887777655444444444 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.028
                 HHHHHH..HHH..CHCH...........HHHHHHHHHHHHHHHHHHHHHHHHHHHS......-HHHHHHHHHHHHHHHHHHHHHHHHHHH....-HH.. CS
        PMEI  15 lCvssLssdpesasasaag.........dLakaalkvalanarsaaaaiskllkkskkkklkkkkaaledClelyedavdeLedalaalk....rskrk 100
                  Cv+sL + +++ +++ ++         d  +  +++  +n+ +  + +++ ++ + k+++++  + l+d   ++++ ++ L++++++      +++++
  EFC35220.1 152 SCVKSLEEENSALKSNLEKlvnkedfknD--MNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRM-KHLNDSMTDINENINKLKESIKSAVekvkSDFSS 247
                 69999988755545444446666533221..333333333333333333333333333344442.58*************9998866555677788888 PP

                 ...HHHHHHHHHHHHHHHHHHHHTTS....S CS
        PMEI 101 .vddaqtwlsaaltdqdtCedgfkea....k 126
                  ++++++ ls    d +t ++ fk +    k
  EFC35220.1 248 eIKSLHSDLSLKKKDVETLLNRFKMDlnklK 278
                 89999*******99**999999977653321 PP

>> Fez1  Fez1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   4.7      0.06        18      20     105 ..     116     197 ..     110     205 .. 0.72
   2 ?    8.8   4.1    0.0068       2.1      45     116 ..     211     287 ..     201     337 .. 0.41

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.06
        Fez1  20 kdsqaevtqklseivalkaqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelse 105
                 k+  +e ++k+   v lk     ++++le  e+++k+le+ +++ ++e+  ++++l++  ++++ +++ +++++ +++++ ++ls+
  EFC35220.1 116 KELIQETATKGT-AVDLKHL--ATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNKEDFKND-MNQVNIKTTNVGKDLSD 197
                 555555555544.3555543..4678899999999999999999999999999999999888888777.77777777766666665 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.0068
        Fez1  45 akleekeeeikeleesleektle....levcenelqrk.kseaellrekvekleeelkelreelselsleeeeaale 116
                 +++++ ++++++++e++++ +++    +e+++++++ + ks ++ l+ k + +e+ l++++ +l++l++++++++ +
  EFC35220.1 211 SRMKHLNDSMTDINENINKLKESiksaVEKVKSDFSSEiKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSEFS 287
                 22222333333222222222222111122222222222344444444444455555555555555544443333322 PP

>> YtxH  YtxH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   8.4      0.17        53      29      62 ..     222     255 ..     105     300 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.17
        YtxH  29 dlkekaddlkekakelleeakekakekaedlkek 62 
                 d++e+ ++lke++k+++e++k+  +++++ l ++
  EFC35220.1 222 DINENINKLKESIKSAVEKVKSDFSSEIKSLHSD 255
                 4555555555555555555555554444444444 PP

>> DUF3644  Protein of unknown function (DUF3644)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.3    0.0032      0.98      38      67 ..     145     173 ..     129     174 .. 0.91
   2 ?    0.8   0.3       2.3     7e+02      32      61 ..     207     233 ..     174     243 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0032
     DUF3644  38 pktisLeeclkkvdkekddpvrkNleaLie 67 
                 ++ + Le c+k +++e+ +++++Nle+L++
  EFC35220.1 145 KRVKTLESCVKSLEEEN-SALKSNLEKLVN 173
                 67899*********976.*********985 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 2.3
     DUF3644  32 knrdGnpktisLeeclkkvdkekddpvrkN 61 
                 kn +G ++ + L++ +++++++  +++++ 
  EFC35220.1 207 KN-NG-SRMKHLNDSMTDINENI-NKLKES 233
                 33.56.77888888888888876.444444 PP

>> COG5  Golgi transport complex subunit 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   1.8      0.34     1e+02      66     109 ..     132     168 ..     109     173 .. 0.42
   2 ?   10.8   1.9    0.0013       0.4      15      90 ..     161     236 ..     160     242 .. 0.93
   3 ?    4.2   3.1      0.14        44      24      91 ..     238     302 ..     234     305 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.34
                 XXXXXXXXXXXXXXXXXXXXXXXXXXX-TTHHHHHHHHHHHHHH CS
        COG5  66 kskslssvlselksslesLsasyerlkskvlepyeeaeklqsal 109
                 k++         +ssle L++ ++ l+s v    ee + l+s l
  EFC35220.1 132 KHLA-------TNSSLEMLEKRVKTLESCVKSLEEENSALKSNL 168
                 3333.......444444444444444444444444444444433 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.0013
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        COG5  15 nallkatnnnddteldlstplkrlnydiqeldkrlrqlitsnhleLlehlskskslssvlselksslesLsasyer 90 
                 n++lk++ ++  +++d +  ++++n  + ++ k l +  +    eL ++ s+ k+l+++++++++++++L++s++ 
  EFC35220.1 161 NSALKSNLEKLVNKEDFKNDMNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKS 236
                 7889999999999************************************************************985 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.14
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        COG5  24 nddteldlstplkrlnydiqeldkrlrqlitsnhleLlehlskskslssvlselksslesLsasyerl 91 
                  ++ ++d s+++k l++d++  +k +++l+++ + +L ++l+k +s   +  ++ s++++L++s++ +
  EFC35220.1 238 VEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDL-NKLKKDRSD--SEFSISSQIQALQKSIDGV 302
                 5688999999999999999999999999999999886.444444443..4557889999999998865 PP

>> XhlA  Haemolysin XhlA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   1.3     0.033        10       6      37 ..     140     171 ..     131     174 .. 0.74
   2 ?    6.5   3.9      0.03       9.4      11      43 ..     211     243 ..     176     247 .. 0.92
   3 ?    6.7   2.0     0.027       8.3       5      41 ..     219     256 ..     215     258 .. 0.57
   4 ?    1.9   0.2      0.87   2.7e+02       9      31 ..     263     285 ..     261     305 .. 0.62

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.033
        XhlA   6 lerietkldnleervdkleekaaeaeekiknl 37 
                 le +e+++++le+ v+ lee ++  +++++ l
  EFC35220.1 140 LEMLEKRVKTLESCVKSLEEENSALKSNLEKL 171
                 66778888888887778888887777777766 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.03
        XhlA  11 tkldnleervdkleekaaeaeekiknleedlkk 43 
                 ++ + l++ +++++e+ ++ +e+ik++ e++k+
  EFC35220.1 211 SRMKHLNDSMTDINENINKLKESIKSAVEKVKS 243
                 57889999999***************9999875 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.027
        XhlA   5 rlerietkldnleerv.dkleekaaeaeekiknleedl 41 
                   + i++++++l+e + + +e+ ++ + ++ik+l+ dl
  EFC35220.1 219 SMTDINENINKLKESIkSAVEKVKSDFSSEIKSLHSDL 256
                 44556666666666331356666666666666666666 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.87
        XhlA   9 ietkldnleervdkleekaaeae 31 
                 +et l+  +++++kl+++ +  e
  EFC35220.1 263 VETLLNRFKMDLNKLKKDRSDSE 285
                 67777777777777777766554 PP

>> SHE3  SWI5-dependent HO expression protein 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4  24.9      0.34   1.1e+02      56     205 ..     142     313 ..     130     346 .. 0.68

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.34
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......HHHHHHHHHHH....H CS
        SHE3  56 nLsslLkRKerrlkdlekelselkesveelklekkqlkkrlenssaseteleeelerlkvqYdalvdsqkeYkehY.......qqeieeLkesl....e 143
                 +L   +k  e  +k le+e+s lk++ e+l   k+ +k+++++ + + t++ ++l+  k   d  ++ +    +h        +++i++Lkes+    e
  EFC35220.1 142 MLEKRVKTLESCVKSLEEENSALKSNLEKLVN-KEDFKNDMNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLndsmtdiNENINKLKESIksavE 239
                 33333444456789999999999999998865.455777777777777777777777777777666544333333311111114556667665422227 PP

                 HHHHHHHSSSXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX............X CS
        SHE3 144 klklenekqleelqerissndkdidtkldsynnkkknlesieeeknkkllkkleslaseld............l 205
                 k k + + +++ l++++s ++kd++t+l+ ++   ++l++   + +  ++++++ l++ +d            +
  EFC35220.1 240 KVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSEFSISSQIQALQKSIDgvnsneggiskfV 313
                 88889999999999999999999999999999999999999999999999999999999987777666644440 PP

>> Laminin_II  Laminin Domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   4.9      0.25        79      26      81 ..     119     174 ..      97     189 .. 0.55
   2 ?    7.9   3.3    0.0092       2.9       4      62 ..     180     242 ..     177     260 .. 0.81
   3 ?    8.5   8.5    0.0062       1.9      12      99 ..     213     299 ..     202     304 .. 0.64

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.25
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHH CS
  Laminin_II  26 lentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelkql 81 
                 +++t  k   ++ +   tn  ++ + k ++  ++ vk Le++   L + l++l ++
  EFC35220.1 119 IQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKLVNK 174
                 33333333344444444455555555555555555555555555555555555554 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0092
                 XXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Laminin_II   4 laaeanetakevleqlap....lsqnlentkeklseinrsveetnekvkdankairdArrsvk 62 
                  ++++n ++++v ++l +    ++ +l+n  + ++++n+s+  +ne+++++++ i++A ++vk
  EFC35220.1 180 DMNQVNIKTTNVGKDLSDfksfMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKVK 242
                 566777778888777776444478899999999*************************99997 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0062
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH....HHHHHHHHHHHH CS
  Laminin_II  12 akevleqlaplsqnlentkeklseinrsveetnekvk.dankairdArrsvkkLeklapqLldklkelkqleeasss.lsdniseikelI 99 
                 +k+  + ++++++n++++ke+++++ ++   ++ + + + +    d + + k++e l+++    l++lk+ ++ s+  +s +i+ +++ I
  EFC35220.1 213 MKHLNDSMTDINENINKLKESIKSAVEK---VKSDFSsEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSEFsISSQIQALQKSI 299
                 4555666666777777777666555444...44444413333334566666777777777777777788777775548******998877 PP

>> BST2  Bone marrow stromal antigen 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   2.0     0.025       7.7      27      85 ..     113     171 ..     109     177 .. 0.80
   2 ?    5.1   0.6      0.11        33      31      83 ..     211     257 ..     189     265 .. 0.47
   3 ?    0.2   0.2       3.7   1.1e+03      43      78 ..     267     302 ..     253     305 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.025
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        BST2  27 tqaqeslreaeaqaatcnqtvvtLkasLekekaqsqkqqakvqelqgeikkLnqkLqda 85 
                 t+ +e ++e+ ++ ++ +      ++sLe+ + + +  ++ v+ l++e+  L+ +L++ 
  EFC35220.1 113 TRVKELIQETATKGTAVDLKHLATNSSLEMLEKRVKTLESCVKSLEEENSALKSNLEKL 171
                 56666666666666666666666679********9*********************986 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.11
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        BST2  31 eslreaeaqaatcnqtvvtLkasLekekaqsqkqqakvqelqgeikkLnqkLq 83 
                   +++ ++ ++  n+ + +Lk+s++  + +         ++  eik+L+  L 
  EFC35220.1 211 SRMKHLNDSMTDINENINKLKESIKSAVEK------VKSDFSSEIKSLHSDLS 257
                 333333333333333333333333333222......12345555555555555 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 3.7
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        BST2  43 cnqtvvtLkasLekekaqsqkqqakvqelqgeikkL 78 
                  n+  ++L++  +   + +    +++q lq+ i   
  EFC35220.1 267 LNRFKMDLNKLKKDRSDSEFSISSQIQALQKSIDGV 302
                 567777777766666666667788888888888765 PP

>> Swi5  Swi5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   1.0     0.016         5       2      30 ..     144     172 ..     143     190 .. 0.78
   2 ?    2.0   3.5      0.73   2.3e+02       7      44 ..     215     253 ..     210     297 .. 0.76
   3 ?   -1.5   0.0       8.9   2.7e+03       9      23 ..     289     303 ..     274     322 .. 0.68

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.016
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        Swi5   2 eaeikeleeqleelekelaelkeelkekk 30 
                 e+++k+le+ +++le+e ++lk++l++  
  EFC35220.1 144 EKRVKTLESCVKSLEEENSALKSNLEKLV 172
                 789999**************999999654 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.73
                 HHHHHHHHHHHHHHHHHHHHHHHH..HHHHHHHHHHHHH CS
        Swi5   7 eleeqleelekelaelkeelkekk.dpeetvkrhIklLh 44 
                  l++ ++ +++++++lke  k+   + +   ++ Ik Lh
  EFC35220.1 215 HLNDSMTDINENINKLKESIKSAVeKVKSDFSSEIKSLH 253
                 555555555555666655555433455566667777776 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 8.9
                 HHHHHHHHHHHHHHH CS
        Swi5   9 eeqleelekelaelk 23 
                  +q+++l+k+++ ++
  EFC35220.1 289 SSQIQALQKSIDGVN 303
                 466666666665554 PP

>> Uso1_p115_C  Uso1 / p115 like vesicle tethering protein, C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  11.0     0.022       6.9       4     113 ..     141     244 ..     110     250 .. 0.77
   2 ?    3.7   5.0      0.25        78      19      85 ..     215     266 ..     177     285 .. 0.52
   3 ?    4.9   2.2       0.1        32       3      62 ..     235     300 ..     233     311 .. 0.75

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.022
  Uso1_p115_C   4 seleseaaslkdeneklkaelqslskalesleqkeakkaaesqakeleaenkklek...eleklraelkeekekekekqkEldDLLlllgDleeKvek 98 
                  + le+++++l++  ++l+ e ++l+++le+l +k      e  ++++++ n+k+++   +l + ++ ++ e +++    k l+D    ++D  e+ +k
   EFC35220.1 141 EMLEKRVKTLESCVKSLEEENSALKSNLEKLVNK------EDFKNDMNQVNIKTTNvgkDLSDFKSFMDGELKNNGSRMKHLND---SMTDINENINK 229
                  4456666666666666666666666666666666......66667777777777766669999999999999999777999999...679******** PP

  Uso1_p115_C  99 ykarLkelGeevsdd 113
                  +k+ +k+  e+v++d
   EFC35220.1 230 LKESIKSAVEKVKSD 244
                  *******99999443 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.25
  Uso1_p115_C  19 klkaelqslskalesleqkeakkaaesqakeleaenkklekeleklraelkeekekekek....qkEldDL 85 
                   l++++ + ++++++l+++  k a e+++++ ++e+k+l +                  +    +k+++ L
   EFC35220.1 215 HLNDSMTDINENINKLKES-IKSAVEKVKSDFSSEIKSLHS------------------DlslkKKDVETL 266
                  3333333444444444444.444444444444444444444..................133333333333 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.1
  Uso1_p115_C   3 aseleseaaslkdeneklkaelqslskalesleqk......eakkaaesqakeleaenkklekele 62 
                  +s++e+ ++++++e ++l ++l+ ++k +e l +       + kk+ +  + ++++++++l+k ++
   EFC35220.1 235 KSAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRfkmdlnKLKKDRSDSEFSISSQIQALQKSID 300
                  688999999999999999999999999999999986666655555666666666666666666544 PP

>> Bacillus_HBL  Bacillus haemolytic enterotoxin (HBL)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2  10.5     0.056        17     108     176 ..     175     243 ..     109     244 .. 0.85
   2 ?    4.9   7.5     0.068        21      84     143 ..     227     285 ..     214     317 .. 0.58

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.056
  Bacillus_HBL 108 ekLqeeiqqnqkevkqlikeLkklklklakdsknFktdvdeltsilagdsgvisqlqneiedlqgkikk 176
                   e+ +++++q + +++++ k+L+++k+ ++ + kn  + ++ l+  +   + +i++l++ i+++ +k+k 
    EFC35220.1 175 EDFKNDMNQVNIKTTNVGKDLSDFKSFMDGELKNNGSRMKHLNDSMTDINENINKLKESIKSAVEKVKS 243
                   456888999999**************************************************9999985 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.068
  Bacillus_HBL  84 FqsyyktlveavdkkdkaellellekLqeeiqqnqkevkqlikeLkklklklakdsknFk 143
                    ++ ++ +++av +k k ++++ ++ L++++  ++k v++l++  k   +kl+kd ++ +
    EFC35220.1 227 INKLKESIKSAV-EKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSE 285
                   344445555555.66677777777777777777777777777766666666666654422 PP

>> DUF4600  Domain of unknown function (DUF4600)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   1.5     0.063        20      42      76 ..     138     171 ..     114     180 .. 0.77
   2 ?    5.8   4.8     0.058        18      13      90 ..     221     298 ..     210     304 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.063
     DUF4600  42 asirvleklteeelnqllkqLekekkslenqlkdl 76 
                 +s+++lek+ +++l++ +k Le+e ++l+++l +l
  EFC35220.1 138 SSLEMLEKR-VKTLESCVKSLEEENSALKSNLEKL 171
                 555555554.6889999************999876 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.058
     DUF4600  13 lelNdqLekqiailkeklekirgnpsdrlasirvleklteeelnqllkqLekekkslenqlkdlelrleqEsKayhka 90 
                 +++N++++k    +k  +ek++++ s + +s+++  +l ++++++ll++ + + ++l+++  d+e+ +    +a +k 
  EFC35220.1 221 TDINENINKLKESIKSAVEKVKSDFSSEIKSLHSDLSLKKKDVETLLNRFKMDLNKLKKDRSDSEFSISSQIQALQKS 298
                 678999999999999999999999999999999999999999999999999999999999999998888888877775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2173  (0.1212); expected 358.6 (0.02)
Passed bias filter:                      680  (0.0379274); expected 358.6 (0.02)
Passed Vit filter:                       143  (0.0079759); expected 17.9 (0.001)
Passed Fwd filter:                        75  (0.00418317); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              58  [number of targets reported over threshold]
# CPU time: 1.13u 0.34s 00:00:01.47 Elapsed: 00:00:00.58
# Mc/sec: 1865.08
//
Query:       EFC35221.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.011   16.2   0.1      0.031   14.8   0.1    1.8  1  2OG-FeII_Oxy  2OG-Fe(II) oxygenase superfamily
      0.042   13.6   0.0      0.095   12.4   0.0    1.5  1  Cupin_2       Cupin domain
      0.094   12.7   0.0       0.16   11.9   0.0    1.5  1  FNIP_M        Folliculin-interacting protein middle domain


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.1   5.2e-06     0.031      12     100 ..     218     297 ..     203     298 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.2e-06
                   S---------EEEEEESSSEEE.EEEE-TT---EEEETEEEE----TTEEEEEE-HHHHHHTTS-S----EEE----GTGSEEEEEEEE- CS
  2OG-FeII_Oxy  12 phpdpevilglgahtdasllti.llqddvgglevfkdgkwlrvppvdnslivniGdallflsngryksvlHrVlpvnegerRvsiayfie 100
                   p++d ++ ++  +h+d   +t+  l    g+++  +++++l+++  + +++v++Gd+ lf++++   +++H V +++ g  R+ + yf +
    EFC35221.1 218 PSNDGHR-IR-KPHKDNLDITPsSLFYF-GNFQ--NTEGYLELTDKNCKVFVQPGDV-LFFKGN---EYKHVVANITSGW-RIGLVYFAH 297
                   5555553.22.35555555666433333.5555..3344888888999********6.666777...688****999988.**9999987 PP

>> Cupin_2  Cupin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.6e-05     0.095      27      61 ..     250     285 ..     248     290 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.6e-05
                 ESEEEEEECTEEEEEETTEEEEE-TT.-EEEEEE-S CS
     Cupin_2  27 eGegeltvdgeeveleaGdsvyfpag.tpHrfrNtg 61 
                 eG++elt  + +v +++Gd+++f+ +   H ++N +
  EFC35221.1 250 EGYLELTDKNCKVFVQPGDVLFFKGNeYKHVVANIT 285
                 9******999***************97778778866 PP

>> FNIP_M  Folliculin-interacting protein middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   2.7e-05      0.16     105     143 ..     154     192 ..     108     219 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.7e-05
      FNIP_M 105 laerfleelsslleeldtkktnfFlstlltavLthhLaW 143
                 +  ++ +el + l+e+ +++ n+++s+llt+v +  +  
  EFC35221.1 154 VTADLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINY 192
                 56677899************************9876665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.36s 00:00:00.96 Elapsed: 00:00:00.55
# Mc/sec: 1752.78
//
Query:       EFC35222.1  [L=219]
Description: syntaxin SYP111, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-51  175.4  16.5    1.8e-51  175.4  16.5    1.5  2  EMP70     Endomembrane protein 70


Domain annotation for each model (and alignments):
>> EMP70  Endomembrane protein 70
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  175.4  16.5     1e-55   1.8e-51     346     518 ..       2     175 ..       1     176 [. 0.97
   2 ?   -3.2   1.2      0.13   2.4e+03     271     291 ..     184     204 ..     177     213 .. 0.68

  Alignments for each domain:
  == domain 1  score: 175.4 bits;  conditional E-value: 1e-55
       EMP70 346 lvffllnlilwakessgalpfgtlvlllllwflisvPlvliGsllgfkkkai.ehpvrtnqiprqipkqpwylkpllsvllgGilpFgaifielyfils 443
                 +++ ++n+++++++s++alpf+t+ ++l l+++is+Pl l+G++ g+++++  e p+rt+++pr+ip+ +wy  + l+ +++G+lpF++i+iel++++ 
  EFC35222.1   2 IIWAIINTVAVSYGSTAALPFKTVAIILGLYLVISFPLLLLGAITGKNFTKGfEAPCRTKKVPREIPPVAWYKDENLMSIVSGFLPFISIYIELHYLYL 100
                 6899********************************************99667********************************************** PP

       EMP70 444 slwlekiYylfgfLflvfllliittaevtilltYfqLcaedyrWwWrSflvggssalYvflysiyYyftklkisg 518
                 s+w +     f + ++v+l+li++t+++ti l+Y+ L++e+++WwWrS+  gg+s+++vf ys+yYy+ +  +sg
  EFC35222.1 101 SMWGQYGHVPFPIVLMVVLILIAVTSCITISLIYLTLSQENHNWWWRSIKFGGTSSIFVFGYSLYYYIMESGMSG 175
                 *****88999**********************************************************9998876 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.13
       EMP70 271 Gvqlllmalvtlllallgfls 291
                 G+ l++ + v l+++++gfls
  EFC35222.1 184 GYNLVIAFAVFLMMSTVGFLS 204
                 666666666666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       906  (0.0505327); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 1589.62
//
Query:       EFC35223.1  [L=249]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      3e-58  197.6   0.0    3.5e-58  197.4   0.0    1.0  1  Ald_Xan_dh_C2  Molybdopterin-binding domain of aldehyde dehyd
  ------ inclusion threshold ------
      0.092   12.6   0.1       0.32   10.8   0.0    1.9  2  Phi-29_GP16_7  Bacteriophage phi-29 early protein GP16.7


Domain annotation for each model (and alignments):
>> Ald_Xan_dh_C2  Molybdopterin-binding domain of aldehyde dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  197.4   0.0     4e-62   3.5e-58     355     550 .]       1     199 [.       1     199 [. 0.93

  Alignments for each domain:
  == domain 1  score: 197.4 bits;  conditional E-value: 4e-62
                    --GGGEEEE-SBTTSSS----S-TT-HHHHHHHHHHHHHHH.HHHHHHHHHHHHCTS-CCCEEEETTEEEETEEEECHHHHHHHHHH.TTSSEEEE CS
  Ald_Xan_dh_C2 355 vpledvrvvegdtdkvpngsgtaaSrstdlngnAvkkAaek.lrerllkiaaellevspedleledgkvvvkeksvslaelaaaayl.ervslsat 448
                    +ple +++++++tdkvpn+s+taaS s+dl+g+Av kA +  +re l  i ++ le  p +l+             +++el+++ay+  ++slsat
     EFC35223.1   1 IPLEFIHLSDTSTDKVPNTSATAASVSSDLYGQAVIKAYNSiIREDLNTIIKQDLERLPPKLTS-----------EEWKELIKNAYFqGDISLSAT 85 
                    7999**********************************98626899*****9888888877655...........49********996788***** PP

                    EEE........EEEETHCHCSBBEEEEEEEEEEEEETTT--EEEEEEEEEEE-BS-S-HHHHHHHHHHHHHHHHHHHHT---EEE.......TTTE CS
  Ald_Xan_dh_C2 449 gfykt.....ldeetgkgppfayfaygaavaeVevDtetgevkvlrvvivhDvGksiNpaivegQieGGfvqGiGlalmEelvyd.......edGq 532
                    g+y+t     +d+++g+g+pf+yf+yg+a++eVe+Dt+tg++ v r +iv+D G+s+Npai++gQieG+f+qG+Gl++mEe++y        ++G+
     EFC35223.1  86 GYYSTskdvwMDWNKGEGKPFNYFTYGCAASEVEIDTLTGDWSVIRSDIVMDLGNSLNPAIDIGQIEGAFIQGMGLYTMEEFIYGdenhqwfQQGS 181
                    ****9*******************************************************************************5344445556** PP

                    ESS-STTTS----GGGS- CS
  Ald_Xan_dh_C2 533 lltasladYkiPtaadiP 550
                    ++t++++ YkiP+a+diP
     EFC35223.1 182 VFTRGPGAYKIPSANDIP 199
                    *****************9 PP

>> Phi-29_GP16_7  Bacteriophage phi-29 early protein GP16.7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   3.6e-05      0.32      57     105 ..       8      57 ..       4      80 .. 0.83
   2 ?   -2.0   0.0      0.32   2.9e+03      84      96 ..     128     140 ..     110     144 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 3.6e-05
                    XXXXXXSSXSSS-HHHHHH.HHHHHHTT----HHHHHHHHTT--SSHHHH CS
  Phi-29_GP16_7  57 isnrsidktvnlsacevav.ldlyeqsniripsdiiedlvnqrlqseqev 105
                    +s+ s dk  n sa   +v  dly q+ i+    ii + +n  ++ + e 
     EFC35223.1   8 LSDTSTDKVPNTSATAASVsSDLYGQAVIKAYNSIIREDLNTIIKQDLER 57 
                    6899**********99888469*********9999988778777766665 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.32
                    ----HHHHHHHHT CS
  Phi-29_GP16_7  84 iripsdiiedlvn 96 
                      i sdi+ dl n
     EFC35223.1 128 SVIRSDIVMDLGN 140
                    3477999999977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (249 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       702  (0.0391544); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1706.94
//
Query:       EFC35224.1  [L=136]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-07   30.9   2.0    9.5e-06   25.3   0.1    2.6  2  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.8   0.2    0.0013        23      19      33 ..       2      16 ..       1      34 [. 0.82
   2 !   25.3   0.1   5.3e-10   9.5e-06       6      47 ..      71     116 ..      66     118 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0013
     DUF4116 19 lseeLknDkeivlkA 33
                ++eeL +D ei+l  
  EFC35224.1  2 IDEELLKDEEIILDF 16
                679999999999865 PP

  == domain 2  score: 25.3 bits;  conditional E-value: 5.3e-10
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtal.....syasee 47 
                 +  vk+ng++l+ +  ++++ ++iv +Av+qn+++l     +y+s+e
  EFC35224.1  71 MFMVKQNGLILEIFT-NHRSCRDIVREAVQQNPSVLdlmcnNYISKE 116
                 6679*****997777.9*****************9955555666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       431  (0.0240393); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.39u 0.28s 00:00:00.67 Elapsed: 00:00:00.43
# Mc/sec: 959.18
//
Query:       EFC35225.1  [L=131]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.5e-08   33.2   0.1    4.7e-08   32.8   0.1    1.1  1  Ras           Ras family
  ------ inclusion threshold ------
       0.11   11.9   0.0       0.14   11.6   0.0    1.2  1  AP_endonuc_2  Xylose isomerase-like TIM barrel


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.8   0.1   5.2e-12   4.7e-08      83     152 ..       3      72 ..       2      82 .. 0.87

  Alignments for each domain:
  == domain 1  score: 32.8 bits;  conditional E-value: 5.2e-12
                 BHHHHHTHH.HHHHHHHHHSTTTSEEEEEEETTTGG.GG-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHHH CS
         Ras  83 sresfenvk.kwveeikrvaeenvpivLvGnKvDle.ekravsteegeelakelglkfletSAktnenveea 152
                 +r++fe+++ kw++ i++  +   +++++++K+D+  ++r+vsteeg ++a+e+g+ f+e+   +  n++++
  EFC35225.1   3 NRNTFEQCTtKWLNLISQRSD--AKVIVIATKTDVGiKNRTVSTEEGLKFANEHGFDFVEICNVNGDNLSKL 72 
                 899*****9899999988877..79*********973589*********************99999998765 PP

>> AP_endonuc_2  Xylose isomerase-like TIM barrel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   1.6e-05      0.14       1      26 [.      48      80 ..      48     104 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.6e-05
                  HHHHHHCT-SEEEEECCTCSHHHHC.......H CS
  AP_endonuc_2  1 laaaaeaGfdgvElfgrdlvpvsel.......s 26
                  l++a e+Gfd+vE++  ++++ s l       s
    EFC35225.1 48 LKFANEHGFDFVEICNVNGDNLSKLesllldnS 80
                  6899******************98866644433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.55
# Mc/sec: 712.28
//
Query:       EFC35226.1  [L=150]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.19   11.3   5.9       0.41   10.3   6.1    1.4  1  TauE             Sulfite exporter TauE/SafE
       0.22   11.6   0.3        0.3   11.1   0.3    1.1  1  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe
       0.42    9.3   1.5       0.51    9.0   1.5    1.1  1  DUF2207          Predicted membrane protein (DUF2207)
        0.8   10.3   4.3         10    6.8   0.8    2.1  2  DUF2627          Protein of unknown function (DUF2627)
        1.9    8.8   3.7        7.5    6.9   1.4    2.1  2  DUF3040          Protein of unknown function (DUF3040)


Domain annotation for each model (and alignments):
>> TauE  Sulfite exporter TauE/SafE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   6.1   0.00011      0.41      91     147 ..      25      84 ..      12      89 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00011
        TauE  91 llkllfgvlllllallmllrkkr...srakgrerrptaillvligglvGllsGllGiGgG 147
                 ++ +++g++ ++l++l+l++++    s+ k+ ++  ++++++ + g++ +++G+  iGgG
  EFC35226.1  25 IFGFIVGFVSIALGVLFLYTPSDysySSSKSDSELFKWAVSAGAFGFCCIIAGYSMIGGG 84 
                 5788999999*******998877777334456888888888888788************9 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.3   8.3e-05       0.3      37      88 ..      16      84 ..       5      89 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 8.3e-05
  Phage_holin_3_6 37 agllgaagvlallalllllval.alal..............aa..lwlaalivaavllvlagvlalvgl 88
                      +++g+++++  + ++++++al +l+l              +    w+     ++++ ++ag  ++ g 
       EFC35226.1 16 TIFAGIGLIIFGFIVGFVSIALgVLFLytpsdysysssksdSElfKWAVSAGAFGFCCIIAGYSMIGGG 84
                     467777777777777777777765555666666666655432146777777778888888888777765 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   1.5   0.00014      0.51     377     426 ..      10      76 ..       3      91 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00014
     DUF2207 377 kkklkklsalglgliilglilillallllvll.................lvfllilllillliaiiv 426
                  +k++  +++g+glii+g+i+++++++l vl+                 l+ +++ + ++++ +ii+
  EFC35226.1  10 YRKATFTIFAGIGLIIFGFIVGFVSIALGVLFlytpsdysysssksdseLFKWAVSAGAFGFCCIIA 76 
                 4566777889999999999999999888888899999********9997444444444444444443 PP

>> DUF2627  Protein of unknown function (DUF2627)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.8    0.0029        10      23      56 ..       3      42 ..       1      43 [. 0.76
   2 ?    4.8   0.1     0.012        41      34      58 ..      59      83 ..      53      85 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0029
     DUF2627 23 mrdalfgilsspfssl......wlqflaGlllfaiglgfi 56
                +rd++ ++ +++f+ +      +  f++G++ +a+g+ f+
  EFC35226.1  3 LRDTMREYRKATFTIFagigliIFGFIVGFVSIALGVLFL 42
                567776666666666666666688999**********997 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.012
     DUF2627 34 pfsslwlqflaGlllfaiglgfiaG 58
                 f++++  +++G+ ++++g ++i+G
  EFC35226.1 59 LFKWAVSAGAFGFCCIIAGYSMIGG 83
                578888999***************9 PP

>> DUF3040  Protein of unknown function (DUF3040)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   1.4    0.0021       7.5      41      76 ..       7      40 ..       2      45 .. 0.70
   2 ?    2.2   0.0     0.062   2.2e+02      42      63 ..      57      78 ..      44      89 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0021
     DUF3040 41 lrrlavlavllfvaGllllvlGvaaaavvlgvvGfv 76
                +r+ +  a+ +++aG+ l+++G+++   v +++G++
  EFC35226.1  7 MRE-YRKATFTIFAGIGLIIFGFIVGF-VSIALGVL 40
                555.7778888999********76665.44555544 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.062
     DUF3040 42 rrlavlavllfvaGllllvlGv 63
                 +l  +av + ++G++++++G 
  EFC35226.1 57 SELFKWAVSAGAFGFCCIIAGY 78
                4556677888888999999983 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1344  (0.0749624); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 906.71
//
Query:       EFC35227.1  [L=138]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.2e-27   92.9   4.4    5.7e-09   36.4   0.1    4.6  5  Sel1      Sel1 repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.013   2.3e+02      29      38 .]       3      12 ..       1      12 [. 0.90
   2 !   28.4   0.0     1e-10   1.8e-06       3      38 .]      15      48 ..      13      48 .. 0.95
   3 !   36.4   0.1   3.2e-13   5.7e-09       3      37 ..      51      83 ..      49      84 .. 0.90
   4 !   23.7   0.0     3e-09   5.5e-05       3      37 ..      87     119 ..      85     120 .. 0.91
   5 ?   -0.8   0.0      0.16   2.9e+03       1      11 [.     121     131 ..     121     131 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.013
        Sel1 29 wyekAAeqGd 38
                w+ k+A+q++
  EFC35227.1  3 WFTKSANQNN 12
                ********86 PP

  == domain 2  score: 28.4 bits;  conditional E-value: 1e-10
        Sel1  3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                Am +L+  +ly+ G+ +p+++++A++w   AAe+Gd
  EFC35227.1 15 AMKKLA--QLYDIGDVIPRNVNEAFKWCLNAAELGD 48
                999***..999***99*******************7 PP

  == domain 3  score: 36.4 bits;  conditional E-value: 3.2e-13
        Sel1  3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37
                ++y+++   +y++G+g+++D +kA+ewy k+A q 
  EFC35227.1 51 SQYDVA--AMYEFGDGTERDLSKAFEWYSKSAHQK 83
                8*****..666*********************986 PP

  == domain 4  score: 23.7 bits;  conditional E-value: 3e-09
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                   +++G  ++y+ G+ v+kD +k++e+  +AAeqG
  EFC35227.1  87 GEFQVG--LMYCLGKHVEKDLSKGLEFALRAAEQG 119
                 67999*..677***********************9 PP

  == domain 5  score: -0.8 bits;  conditional E-value: 0.16
        Sel1   1 aeAmyrLGmfy 11 
                 + A+y ++ +y
  EFC35227.1 121 SKAQYVVADMY 131
                 689**999666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (138 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       328  (0.0182944); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.34s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 807.66
//
Query:       EFC35228.1  [L=351]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-21   74.7  17.2     0.0023   18.6   0.0    7.5  7  Sel1         Sel1 repeat
    2.5e-11   43.1   4.9    4.3e-09   35.9   0.2    4.8  4  TPR_11       TPR repeat
      7e-11   42.0   9.3        1.4    9.7   0.0    7.6  8  TPR_6        Tetratricopeptide repeat
    1.2e-08   34.4  35.6    7.9e-08   31.8   0.5    9.6 11  TPR_1        Tetratricopeptide repeat
    3.3e-08   33.7   4.3     0.0014   18.8   0.0    6.7  6  TPR_12       Tetratricopeptide repeat
    6.4e-08   32.1  29.5    1.1e-05   25.1   0.3    9.3 11  TPR_2        Tetratricopeptide repeat
    1.9e-07   31.6   0.0    5.1e-05   23.8   0.0    3.6  3  TPR_16       Tetratricopeptide repeat
    1.3e-06   28.0   1.3       0.81    9.9   0.0    5.8  7  TPR_7        Tetratricopeptide repeat
      2e-06   27.8  13.1    0.00062   20.0   0.1    6.3  6  TPR_17       Tetratricopeptide repeat
    5.2e-05   23.1   0.2    5.2e-05   23.1   0.2    6.9  6  TPR_8        Tetratricopeptide repeat
    0.00044   20.8   0.0       0.17   12.8   0.0    4.4  5  TPR_14       Tetratricopeptide repeat
     0.0032   17.9   5.9       0.45   11.1   0.1    4.4  4  TPR_19       Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.023   14.9   0.0      0.089   13.0   0.0    2.0  1  TPR_9        Tetratricopeptide repeat
      0.023   14.9  14.8       0.06   13.6   0.2    5.1  5  ANAPC3       Anaphase-promoting complex, cyclosome, subunit 3
      0.044   13.2   0.0      0.078   12.4   0.0    1.4  1  Coatomer_E   Coatomer epsilon subunit
        0.1   12.3   0.1        1.2    8.8   0.0    2.5  3  TOM20_plant  Plant specific mitochondrial import receptor sub
       0.11   12.5   0.3       0.11   12.5   0.3    3.7  4  Fis1_TPR_C   Fis1 C-terminal tetratricopeptide repeat
       0.15   11.6   3.3       0.36   10.3   0.1    3.1  4  SHNi-TPR     SHNi-TPR
       0.19   12.0   1.5         34    5.0   0.0    4.7  5  PPR          PPR repeat
        0.2   11.1   3.3          3    7.2   0.2    3.3  4  SPO22        Meiosis protein SPO22/ZIP4 like


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       3.9   3.5e+03      21      28 ..      73      80 ..      68      89 .. 0.71
   2 !    8.9   0.0    0.0029       2.6       6      33 ..      98     123 ..      93     125 .. 0.88
   3 ?    5.0   0.0     0.046        41      14      32 ..     175     195 ..     170     196 .. 0.80
   4 !   18.6   0.0   2.6e-06    0.0023       4      32 ..     202     229 ..     199     231 .. 0.85
   5 !   18.3   0.1     3e-06    0.0027       8      31 ..     237     258 ..     235     259 .. 0.94
   6 !   11.0   0.1   0.00061      0.55       6      29 ..     267     291 ..     266     293 .. 0.90
   7 !   17.8   1.1   4.3e-06    0.0038       2      30 ..     311     342 ..     310     344 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 3.9
        Sel1 21 kDpekAie 28
                k++ekAie
  EFC35228.1 73 KNYEKAIE 80
                58888886 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0029
        Sel1   6 rLGmfylylnGlgvpkDpekAiewyekA 33 
                  LG   +y +G  v+kD +kAi ++e++
  EFC35228.1  98 SLG--VCYKEGGCVKKDWDKAISLFERS 123
                 599..999***66*************95 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.046
        Sel1  14 lnGlgvpk..DpekAiewyek 32 
                 ++Gl      D+ kA+ew++k
  EFC35228.1 175 EYGLLCLNcnDYLKAVEWLKK 195
                 567666666699*******99 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 2.6e-06
        Sel1   4 myrLGmfylylnGlg.vpkDpekAiewyek 32 
                    LG   ly+nG   v kDp+kA+e+y k
  EFC35228.1 202 NTYLG--NLYMNGSTtVQKDPRKAFEYYSK 229
                 5679*..667****66************99 PP

  == domain 5  score: 18.3 bits;  conditional E-value: 3e-06
        Sel1   8 GmfylylnGlgvpkDpekAiewye 31 
                 +  y+y++G g+ kDp+kA++ y+
  EFC35228.1 237 A--YCYEEGIGTQKDPQKAFKMYQ 258
                 6..9*****************998 PP

  == domain 6  score: 11.0 bits;  conditional E-value: 0.00061
        Sel1   6 rLGmfylylnGl.gvpkDpekAiew 29 
                 +LGm  +y++G  g+ +D++k +++
  EFC35228.1 267 KLGMGRMYFKGWeGTNPDYQKSFKY 291
                 78888999****99*********99 PP

  == domain 7  score: 17.8 bits;  conditional E-value: 4.3e-06
        Sel1   2 eAmyrLGmfylylnGlgvpkD.....pekAiewy 30 
                 eAmy L+  ++y++G+g+p D      ekA  +y
  EFC35228.1 311 EAMYYLA--EMYYYGKGIPEDellhhTEKAASYY 342
                 8******..888********97777777777776 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.44   3.9e+02       3      25 ..      34      56 ..      32      60 .. 0.77
   2 !   35.9   0.2   4.8e-12   4.3e-09       5      40 ..      70     105 ..      67     107 .. 0.90
   3 ?    3.4   0.0     0.068        61      27      39 ..     125     137 ..     111     138 .. 0.79
   4 ?    0.5   0.1      0.56     5e+02       8      19 ..     184     195 ..     177     212 .. 0.56

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.44
      TPR_11  3 ayyeqGkyeeAieaYkkAlkldP 25
                 +y   +ye+A+  +++ ++ dP
  EFC35228.1 34 SFYTEKEYEKALLILNQIIESDP 56
                67888899999987777777666 PP

  == domain 2  score: 35.9 bits;  conditional E-value: 4.8e-12
      TPR_11   5 yeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40 
                  ++ +ye+Aie++++Al+ldP+na+ ++ LG+ y +
  EFC35228.1  70 KKLKNYEKAIEDLNRALELDPNNASYLNSLGVCYKE 105
                 67889**************************98865 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.068
      TPR_11  27 naeayynLGlayy 39 
                 n  a+ynLG +y 
  EFC35228.1 125 NGQAFYNLGIIYK 137
                 55799****9995 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.56
      TPR_11   8 GkyeeAieaYkk 19 
                 ++y +A+e++kk
  EFC35228.1 184 NDYLKAVEWLKK 195
                 555555555554 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   0.0    0.0016       1.4       4      31 ..      29      56 ..      28      57 .. 0.92
   2 !    8.6   0.0    0.0036       3.3      10      32 ..      69      91 ..      67      92 .. 0.89
   3 !    9.5   0.0    0.0019       1.7       6      25 ..      99     122 ..      98     125 .. 0.92
   4 ?   -0.4   0.0       2.6   2.3e+03       1      11 [.     127     137 ..     127     144 .. 0.88
   5 ?    0.6   0.0       1.3   1.1e+03       6      24 ..     205     228 ..     204     229 .. 0.78
   6 ?    4.1   0.1     0.099        89       6      25 ..     236     259 ..     235     259 .. 0.88
   7 ?   -1.0   0.0         4   3.6e+03       4      18 ..     268     287 ..     265     295 .. 0.71
   8 ?    5.1   1.5     0.045        41       1      23 [.     311     342 ..     311     346 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0016
                HHHHHHHHHHHHHHHHHHHHHHHHHH-T CS
       TPR_6  4 yklalsyrklgdtdkAlealerlikeYP 31
                + +a+s++  ++++kAl +l+++i++ P
  EFC35228.1 29 FGRAKSFYTEKEYEKALLILNQIIESDP 56
                6789****988**************998 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0036
                HHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6 10 yrklgdtdkAlealerlikeYPd 32
                ++kl++++kA+e l+r ++  P+
  EFC35228.1 69 FKKLKNYEKAIEDLNRALELDPN 91
                67799***************999 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.0019
                 HHHHHHHH....HHHHHHHHHHHH CS
       TPR_6   6 lalsyrkl....gdtdkAlealer 25 
                 l+ +y+++    +d+dkA+ ++er
  EFC35228.1  99 LGVCYKEGgcvkKDWDKAISLFER 122
                 799****77**99*********98 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 2.6
                 HHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyr 11 
                 +A+y+l+  y+
  EFC35228.1 127 QAFYNLGIIYK 137
                 69*****9996 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 1.3
                 HHHHHHHH.....HHHHHHHHHHH CS
       TPR_6   6 lalsyrkl.....gdtdkAleale 24 
                 l+ +y ++     +d++kA e++ 
  EFC35228.1 205 LGNLYMNGsttvqKDPRKAFEYYS 228
                 67777777777779*******996 PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.099
                 HHHHHHHH....HHHHHHHHHHHH CS
       TPR_6   6 lalsyrkl....gdtdkAlealer 25 
                  a++y+++    +d++kA +++++
  EFC35228.1 236 HAYCYEEGigtqKDPQKAFKMYQE 259
                 599****999989999*****995 PP

  == domain 7  score: -1.0 bits;  conditional E-value: 4
                 HHHHHHHHHH.....HHHHH CS
       TPR_6   4 yklalsyrkl.....gdtdk 18 
                 + +++ y+k+      d++k
  EFC35228.1 268 LGMGRMYFKGwegtnPDYQK 287
                 789999*9987776446555 PP

  == domain 8  score: 5.1 bits;  conditional E-value: 0.045
                 HHHHHHHHHHHHH.........HHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl.........gdtdkAleal 23 
                 +A+y+la+ y+ +           t+kA  ++
  EFC35228.1 311 EAMYYLAEMYYYGkgipedellHHTEKAASYY 342
                 7**********975555555554555555555 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0    0.0032       2.9       5      33 ..      29      57 ..      27      58 .. 0.91
   2 !   31.8   0.5   8.8e-11   7.9e-08      10      34 .]      68      92 ..      67      92 .. 0.95
   3 ?    3.1   0.1       0.1        93      14      25 ..     110     121 ..      93     123 .. 0.54
   4 ?    4.5   0.1     0.038        34       2      12 ..     127     137 ..     126     139 .. 0.88
   5 ?    2.7   0.0      0.14   1.2e+02       8      26 ..     177     195 ..     177     196 .. 0.92
   6 ?   -2.1   0.2       4.6   4.1e+03       6      12 ..     204     210 ..     203     211 .. 0.82
   7 ?    3.1   0.0       0.1        93      14      26 ..     217     229 ..     215     230 .. 0.91
   8 ?    0.4   0.1      0.72   6.5e+02      14      26 ..     247     259 ..     246     260 .. 0.91
   9 ?   -2.9   0.1       7.9   7.1e+03      16      27 ..     284     295 ..     284     297 .. 0.76
  10 ?   -2.8   1.0       7.5   6.7e+03       3      12 ..     312     321 ..     311     323 .. 0.80
  11 ?   -2.5   0.1       6.2   5.6e+03       1       6 [.     338     343 ..     334     344 .. 0.49

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0032
                HHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1  5 ynlGnayfklgkydeAleyyekALelnPn 33
                ++++  ++  ++y++Al   ++ +e +P+
  EFC35228.1 29 FGRAKSFYTEKEYEKALLILNQIIESDPT 57
                579999************99999999996 PP

  == domain 2  score: 31.8 bits;  conditional E-value: 8.8e-11
                HHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1 10 ayfklgkydeAleyyekALelnPnn 34
                ++ kl++y++A+e+ ++ALel+Pnn
  EFC35228.1 68 TFKKLKNYEKAIEDLNRALELDPNN 92
                689*********************8 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.1
                 TT-HHHHHHHHH CS
       TPR_1  14 lgkydeAleyye 25 
                 ++++d+A+  +e
  EFC35228.1 110 KKDWDKAISLFE 121
                 456666666666 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.038
                 HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayf 12 
                 +a+ynlG +y 
  EFC35228.1 127 QAFYNLGIIYK 137
                 699*******6 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.14
                 HHHHHHTT-HHHHHHHHHH CS
       TPR_1   8 GnayfklgkydeAleyyek 26 
                 G+++++ ++y +A+e  +k
  EFC35228.1 177 GLLCLNCNDYLKAVEWLKK 195
                 8999***********9998 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 4.6
                 HHHHHHH CS
       TPR_1   6 nlGnayf 12 
                  lGn+y+
  EFC35228.1 204 YLGNLYM 210
                 69****8 PP

  == domain 7  score: 3.1 bits;  conditional E-value: 0.1
                 TT-HHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyek 26 
                 ++++ +A eyy+k
  EFC35228.1 217 QKDPRKAFEYYSK 229
                 89*********98 PP

  == domain 8  score: 0.4 bits;  conditional E-value: 0.72
                 TT-HHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyek 26 
                 ++++++A + y++
  EFC35228.1 247 QKDPQKAFKMYQE 259
                 89*********96 PP

  == domain 9  score: -2.9 bits;  conditional E-value: 7.9
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 +y++  +y+ ++
  EFC35228.1 284 DYQKSFKYCTEV 295
                 688888888875 PP

  == domain 10  score: -2.8 bits;  conditional E-value: 7.5
                 HHHHHHHHHH CS
       TPR_1   3 alynlGnayf 12 
                 a y l+ +y+
  EFC35228.1 312 AMYYLAEMYY 321
                 7899999998 PP

  == domain 11  score: -2.5 bits;  conditional E-value: 6.2
                 HHHHHH CS
       TPR_1   1 akalyn 6  
                 a ++yn
  EFC35228.1 338 AASYYN 343
                 334444 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0      0.25   2.3e+02      51      73 ..      31      53 ..      22      57 .. 0.72
   2 !   18.8   0.0   1.6e-06    0.0014      15      72 ..      71     124 ..      62     127 .. 0.88
   3 ?    0.4   0.0      0.92   8.3e+02       9      29 ..     176     196 ..     169     196 .. 0.63
   4 ?   -1.2   0.0       2.8   2.5e+03      16      29 ..     217     230 ..     215     233 .. 0.69
   5 ?   -0.1   0.0       1.3   1.2e+03      16      28 ..     247     259 ..     245     263 .. 0.60
   6 ?    4.0   0.1     0.069        62      18      57 ..     284     322 ..     284     343 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.25
      TPR_12 51 LgrlyralgryeeAlelleeala 73
                 +  ++  ++ye+Al +l++ ++
  EFC35228.1 31 RAKSFYTEKEYEKALLILNQIIE 53
                56666777788888888888765 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 1.6e-06
      TPR_12  15 rlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralg....ryeeAlelleeal 72 
                 +l++y++A+e l++ale+      p++   a++l+ Lg +y + g    ++++A++l+e++ 
  EFC35228.1  71 KLKNYEKAIEDLNRALELD-----PNN---ASYLNSLGVCYKEGGcvkkDWDKAISLFERSR 124
                 799****************.....987...99*********996666669999999999986 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.92
      TPR_12   9 laavlrrlgrydeAlelleka 29 
                 ++++++   +y +A e+l+k+
  EFC35228.1 176 YGLLCLNCNDYLKAVEWLKKS 196
                 455555666666666666654 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 2.8
      TPR_12  16 lgrydeAlelleka 29 
                 +++  +A+e++ k+
  EFC35228.1 217 QKDPRKAFEYYSKS 230
                 56666777777665 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 1.3
      TPR_12  16 lgrydeAlellek 28 
                 +++ ++A++++++
  EFC35228.1 247 QKDPQKAFKMYQE 259
                 4555555555554 PP

  == domain 6  score: 4.0 bits;  conditional E-value: 0.069
      TPR_12  18 rydeAlellekaleiarrllGpdhpltattlrnLgrlyra 57 
                 +y+++++++ ++ e + ++  ++ +l  ++++ L+++y++
  EFC35228.1 284 DYQKSFKYCTEVFEYCINTK-DNQDLKNEAMYYLAEMYYY 322
                 79**************9994.5667889999999999864 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0    0.0021       1.9       5      33 ..      29      57 ..      28      58 .. 0.93
   2 !   25.1   0.3   1.2e-08   1.1e-05      12      34 .]      70      92 ..      67      92 .. 0.93
   3 ?    4.3   0.0     0.059        52      14      27 ..     110     123 ..      93     125 .. 0.88
   4 ?    0.1   0.0       1.3   1.2e+03       3      11 ..     128     136 ..     126     139 .. 0.84
   5 ?    4.4   0.1     0.052        47       6      26 ..     175     195 ..     171     196 .. 0.89
   6 ?   -2.3   0.1       7.5   6.7e+03       6      13 ..     204     211 ..     200     211 .. 0.80
   7 ?    0.4   0.0         1   9.4e+02      14      26 ..     217     229 ..     216     232 .. 0.89
   8 ?   -1.4   0.0       3.8   3.4e+03      14      26 ..     247     259 ..     246     259 .. 0.87
   9 ?   -2.2   0.0       7.2   6.4e+03      16      29 ..     284     297 ..     284     300 .. 0.79
  10 ?    1.0   1.1      0.65   5.8e+02       2      13 ..     311     322 ..     310     324 .. 0.89
  11 ?   -1.1   0.0       3.2   2.9e+03      15      25 ..     333     343 ..     330     346 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0021
       TPR_2  5 ynlGlayyklgdyeeAleafekAleldPn 33
                + ++++ y  ++ye+Al  +++ +e dP+
  EFC35228.1 29 FGRAKSFYTEKEYEKALLILNQIIESDPT 57
                57999*********************997 PP

  == domain 2  score: 25.1 bits;  conditional E-value: 1.2e-08
       TPR_2 12 yklgdyeeAleafekAleldPnn 34
                 kl++ye+A+e++++AleldPnn
  EFC35228.1 70 KKLKNYEKAIEDLNRALELDPNN 92
                689*******************8 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.059
       TPR_2  14 lgdyeeAleafekA 27 
                 ++d+++A+ +fe++
  EFC35228.1 110 KKDWDKAISLFERS 123
                 58999***999985 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 1.3
       TPR_2   3 alynlGlay 11 
                 a ynlG +y
  EFC35228.1 128 AFYNLGIIY 136
                 889***999 PP

  == domain 5  score: 4.4 bits;  conditional E-value: 0.052
       TPR_2   6 nlGlayyklgdyeeAleafek 26 
                 + Gl++++ +dy +A+e+++k
  EFC35228.1 175 EYGLLCLNCNDYLKAVEWLKK 195
                 5799**************998 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 7.5
       TPR_2   6 nlGlayyk 13 
                 +lG++y++
  EFC35228.1 204 YLGNLYMN 211
                 89999985 PP

  == domain 7  score: 0.4 bits;  conditional E-value: 1
       TPR_2  14 lgdyeeAleafek 26 
                 ++d+ +A e++ k
  EFC35228.1 217 QKDPRKAFEYYSK 229
                 78999******88 PP

  == domain 8  score: -1.4 bits;  conditional E-value: 3.8
       TPR_2  14 lgdyeeAleafek 26 
                 ++d+++A + +++
  EFC35228.1 247 QKDPQKAFKMYQE 259
                 7899***999986 PP

  == domain 9  score: -2.2 bits;  conditional E-value: 7.2
       TPR_2  16 dyeeAleafekAle 29 
                 dy++  +++ ++ e
  EFC35228.1 284 DYQKSFKYCTEVFE 297
                 79999999988766 PP

  == domain 10  score: 1.0 bits;  conditional E-value: 0.65
       TPR_2   2 ealynlGlayyk 13 
                 ea y+l++ yy+
  EFC35228.1 311 EAMYYLAEMYYY 322
                 899*******97 PP

  == domain 11  score: -1.1 bits;  conditional E-value: 3.2
       TPR_2  15 gdyeeAleafe 25 
                  + e+A+ +++
  EFC35228.1 333 HHTEKAASYYN 343
                 56688888886 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0      0.21   1.8e+02      38      65 ..      29      56 ..      29      59 .. 0.64
   2 !   23.8   0.0   5.6e-08   5.1e-05       9      60 ..      71     123 ..      68     133 .. 0.93
   3 ?   -1.1   0.0       3.5   3.1e+03      34      45 ..     310     321 ..     304     330 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.21
      TPR_16 38 lllgdaalrqgrlaeAaalyraalraap 65
                ++++ +++  +++++A+  ++  ++ +p
  EFC35228.1 29 FGRAKSFYTEKEYEKALLILNQIIESDP 56
                5677777777777777766666556665 PP

  == domain 2  score: 23.8 bits;  conditional E-value: 5.6e-08
      TPR_16   9 ragdyddAaaaleaalkrdpssPdaaeAllllgdaalrq....grlaeAaalyraa 60 
                 ++++y++A++ l++al++d   P +a  l+ lg+++ +     +++++A+ l+++ 
  EFC35228.1  71 KLKNYEKAIEDLNRALELD---PNNASYLNSLGVCYKEGgcvkKDWDKAISLFERS 123
                 579****************...****************99**********999986 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 3.5
      TPR_16  34 aeAllllgdaal 45 
                  eA+++l+++++
  EFC35228.1 310 NEAMYYLAEMYY 321
                 689999999987 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       5.6     5e+03      14      24 ..      40      50 ..      32      58 .. 0.69
   2 !    8.6   0.0    0.0024       2.1       9      35 ..      69      93 ..      67      94 .. 0.85
   3 !    9.9   0.0    0.0009      0.81       2      24 ..      96     122 ..      95     123 .. 0.88
   4 ?   -2.2   0.0       6.6     6e+03       1       9 [.     128     136 ..     128     137 .. 0.86
   5 ?    1.6   0.0      0.39   3.5e+02       7      24 ..     178     195 ..     177     196 .. 0.88
   6 ?   -1.3   0.0       3.3     3e+03       4      22 ..     204     227 ..     203     230 .. 0.73
   7 ?   -1.1   0.1       2.9   2.6e+03      15      22 ..     335     342 ..     333     344 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 5.6
       TPR_7 14 dyeeAielyeq 24
                +ye+A+ ++ q
  EFC35228.1 40 EYEKALLILNQ 50
                67888766665 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0024
       TPR_7  9 ysrlGdyeeAielyeqsLaltkdpeda 35
                + +l +ye+Aie + +  al+ dp++a
  EFC35228.1 69 FKKLKNYEKAIEDLNR--ALELDPNNA 93
                66788***********..999999876 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.0009
       TPR_7   2 LlnLarlysr....lGdyeeAielyeq 24 
                 L+ L+++y +      d+++Ai+l+e+
  EFC35228.1  96 LNSLGVCYKEggcvKKDWDKAISLFER 122
                 6889999999888899**********9 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 6.6
       TPR_7   1 aLlnLarly 9  
                 a++nL+ +y
  EFC35228.1 128 AFYNLGIIY 136
                 679****99 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.39
       TPR_7   7 rlysrlGdyeeAielyeq 24 
                  l+ +++dy +A+e +++
  EFC35228.1 178 LLCLNCNDYLKAVEWLKK 195
                 68999*********9998 PP

  == domain 6  score: -1.3 bits;  conditional E-value: 3.3
       TPR_7   4 nLarlysr.....lGdyeeAiely 22 
                 +L++ly +     + d ++A e+y
  EFC35228.1 204 YLGNLYMNgsttvQKDPRKAFEYY 227
                 699999887777777777777777 PP

  == domain 7  score: -1.1 bits;  conditional E-value: 2.9
       TPR_7  15 yeeAiely 22 
                 +e+A+++y
  EFC35228.1 335 TEKAASYY 342
                 79*****9 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0     0.031        28       3      34 .]      49      80 ..      47      80 .. 0.90
   2 !   20.0   0.1     7e-07   0.00062       3      33 ..      83     117 ..      81     122 .. 0.84
   3 ?    4.3   0.0     0.072        64      10      24 ..     123     137 ..     113     150 .. 0.74
   4 ?   -0.9   0.0       3.1   2.8e+03      18      33 ..     175     190 ..     167     191 .. 0.81
   5 ?    1.1   0.1      0.74   6.6e+02       2      25 ..     186     211 ..     185     225 .. 0.70
   6 ?    0.4   0.6       1.3   1.1e+03      14      24 ..     311     321 ..     311     338 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.031
      TPR_17  3 lkaleldPnnadaynnLAelllknGdlmtArq 34
                 + +e dP+ + +++++  +++k++++++A++
  EFC35228.1 49 NQIIESDPTKSIFLHQRYLTFKKLKNYEKAIE 80
                5789*************999******999986 PP

  == domain 2  score: 20.0 bits;  conditional E-value: 7e-07
      TPR_17   3 lkaleldPnnadaynnLAelll....knGdlmtAr 33 
                  +aleldPnna  +n L+++++     ++d+++A+
  EFC35228.1  83 NRALELDPNNASYLNSLGVCYKeggcVKKDWDKAI 117
                 69*******************96666555777775 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.072
      TPR_17  10 PnnadaynnLAelll 24 
                   n  a++nL+ +++
  EFC35228.1 123 SRNGQAFYNLGIIYK 137
                 56899*********9 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 3.1
      TPR_17  18 nLAelllknGdlmtAr 33 
                 +++ l l+ +d+ +A+
  EFC35228.1 175 EYGLLCLNCNDYLKAV 190
                 6888889999998886 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.74
      TPR_17   2 ylkaleldPnn..adaynnLAelllk 25 
                 ylka+e  +++  + + ++L++l+ +
  EFC35228.1 186 YLKAVEWLKKSdtPLSNTYLGNLYMN 211
                 7777777666557889999***9983 PP

  == domain 6  score: 0.4 bits;  conditional E-value: 1.3
      TPR_17  14 daynnLAelll 24 
                 +a+++LAe ++
  EFC35228.1 311 EAMYYLAEMYY 321
                 689*****886 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.1      0.06        53      10      33 ..      34      57 ..      29      58 .. 0.85
   2 !   23.1   0.2   5.8e-08   5.2e-05      10      34 .]      68      92 ..      67      92 .. 0.93
   3 ?    0.5   0.0         1   9.4e+02       2      12 ..     127     137 ..     126     139 .. 0.87
   4 ?    5.8   0.1     0.021        19       7      27 ..     176     196 ..     173     198 .. 0.90
   5 ?    0.2   0.0       1.3   1.2e+03      15      30 ..     218     233 ..     217     235 .. 0.81
   6 ?   -2.0   0.0       6.5   5.8e+03      18      25 ..     336     343 ..     334     346 .. 0.66

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.06
                HHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8 10 iylklgdyeeAkeyyekaleldpd 33
                   + ++ye+A   +++ +e dp+
  EFC35228.1 34 SFYTEKEYEKALLILNQIIESDPT 57
                5667899**************996 PP

  == domain 2  score: 23.1 bits;  conditional E-value: 5.8e-08
                HHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8 10 iylklgdyeeAkeyyekaleldpdn 34
                + +kl++ye+A+e +++aleldp+n
  EFC35228.1 68 TFKKLKNYEKAIEDLNRALELDPNN 92
                5789*******************97 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 1
                 CHHHHHHHHHH CS
       TPR_8   2 eayynlgsiyl 12 
                 +a ynlg iy+
  EFC35228.1 127 QAFYNLGIIYK 137
                 689*******7 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.021
                 HHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   7 lgsiylklgdyeeAkeyyeka 27 
                  g+++l+ +dy +A+e+++k 
  EFC35228.1 176 YGLLCLNCNDYLKAVEWLKKS 196
                 6999***************96 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 1.3
                 T-HHHHHHHHHHHHHH CS
       TPR_8  15 gdyeeAkeyyekalel 30 
                 +d  +A eyy k  ++
  EFC35228.1 218 KDPRKAFEYYSKSNTI 233
                 78899*****997655 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 6.5
                 HHHHHHHH CS
       TPR_8  18 eeAkeyye 25 
                 e+A +yy+
  EFC35228.1 336 EKAASYYN 343
                 67777776 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0       1.1   9.6e+02       7      33 ..      31      57 ..      29      68 .. 0.84
   2 !   12.8   0.0   0.00019      0.17      11      38 ..      69      96 ..      60     102 .. 0.84
   3 ?   -0.6   0.0       3.9   3.5e+03      16      27 ..     112     123 ..     110     125 .. 0.86
   4 ?   -1.7   0.0       8.5   7.6e+03       5      26 ..     174     195 ..     172     197 .. 0.84
   5 ?   -1.5   0.0       7.2   6.5e+03      14      26 ..     247     259 ..     246     259 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 1.1
      TPR_14  7 laeallalGdpdeAiallrralalaPd 33
                +a+ +++  ++++A+ +l+++++ +P+
  EFC35228.1 31 RAKSFYTEKEYEKALLILNQIIESDPT 57
                5778889999***********999985 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 0.00019
      TPR_14 11 llalGdpdeAiallrralalaPddaeaw 38
                +  l ++++Ai+ l+ral+l+P++a ++
  EFC35228.1 69 FKKLKNYEKAIEDLNRALELDPNNASYL 96
                66789*******************9776 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 3.9
      TPR_14  16 dpdeAiallrra 27 
                 d+d+Ai l++r 
  EFC35228.1 112 DWDKAISLFERS 123
                 899*****9985 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 8.5
      TPR_14   5 lalaeallalGdpdeAiallrr 26 
                 ++++ ++l+  d+ +A++ l++
  EFC35228.1 174 QEYGLLCLNCNDYLKAVEWLKK 195
                 6789999999999999999986 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 7.2
      TPR_14  14 lGdpdeAiallrr 26 
                 + dp++A +++++
  EFC35228.1 247 QKDPQKAFKMYQE 259
                 6799******985 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0     0.021        19      36      57 ..      36      57 ..      29      71 .. 0.85
   2 !   11.1   0.1    0.0005      0.45       5      37 ..      73     105 ..      71     124 .. 0.81
   3 ?   -0.0   0.0       1.4   1.3e+03       5      34 ..     111     135 ..     103     138 .. 0.74
   4 ?   -1.3   0.1       3.7   3.3e+03      21      50 ..     166     195 ..     158     197 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.021
      TPR_19 36 lalgqldeAealLdalpeedpd 57
                +  +++++A  +L+++ e+dp 
  EFC35228.1 36 YTEKEYEKALLILNQIIESDPT 57
                56689*************9996 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.0005
      TPR_19   5 gdyaeAlalleqalqedpknaearllLAealla 37 
                 ++y+ A++ l +al+ dp+na  +  L  ++ +
  EFC35228.1  73 KNYEKAIEDLNRALELDPNNASYLNSLGVCYKE 105
                 478889999999999999988888888888866 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 1.4
      TPR_19   5 gdyaeAlalleqalqedpknaearllLAea 34 
                 +d + A++l+e+       n+ a ++L ++
  EFC35228.1 111 KDWDKAISLFERS-----RNGQAFYNLGII 135
                 4889999999995.....566666666655 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 3.7
      TPR_19  21 dpknaearllLAeallalgqldeAealLda 50 
                 + +n   +  +  ++l+ +++ +A + L++
  EFC35228.1 166 EKDNKLCQQEYGLLCLNCNDYLKAVEWLKK 195
                 556666666777789999999999999975 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   9.9e-05     0.089       8      62 ..      38      92 ..      34      98 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 9.9e-05
       TPR_9  8 eedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapda 62
                e+++e+al +++ ++  +P     +  R l   +l ++++A++dL+++l+l+p++
  EFC35228.1 38 EKEYEKALLILNQIIESDPTKSIFLHQRYLTFKKLKNYEKAIEDLNRALELDPNN 92
                6788999999999999999999999999999999*******************76 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.2   6.7e-05      0.06      30      79 ..      32      82 ..      27      85 .. 0.85
   2 ?    7.7   0.1    0.0045       4.1       3      49 ..      73     123 ..      71     136 .. 0.72
   3 ?    4.9   0.3     0.034        30      27      51 ..     174     198 ..     142     214 .. 0.77
   4 ?   -0.0   0.2       1.2   1.1e+03      26      65 ..     233     273 ..     221     276 .. 0.61
   5 ?    0.4   0.3      0.88   7.9e+02      22      34 ..     309     321 ..     284     325 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 6.7e-05
                HHHHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHHHHH.H.HTT-HHHHHHHH CS
      ANAPC3 30 AlclylngqykrAyellrkaklnskslgcrylfAqcl.l.kLkkyeeAiaaL 79
                A+++y  ++y++A+ +l++  ++s   ++ +l+ + l + kLk+ye+Ai  L
  EFC35228.1 32 AKSFYTEKEYEKALLILNQI-IESDPTKSIFLHQRYLtFkKLKNYEKAIEDL 82
                8999****************.66666688999998884489*******9866 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0045
                 T-HHHHHHHHHHHH.HHH--HHHHHHHHHHH....HHTT-HHHHHHHHHCT CS
      ANAPC3   3 nnyknAiflaerllaaetespedayllAlcl....ylngqykrAyellrka 49 
                 +ny++Ai  ++r+l+ ++++++ +  l+ c+    +  +++++A+ l++++
  EFC35228.1  73 KNYEKAIEDLNRALELDPNNASYLNSLGVCYkeggCVKKDWDKAISLFERS 123
                 578888888888888888888888888888844444456677777777776 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.034
                 HHHHHHHHHTT-HHHHHHHHHCTSH CS
      ANAPC3  27 yllAlclylngqykrAyellrkakl 51 
                   ++l  ++ ++y +A e+l+k+++
  EFC35228.1 174 QEYGLLCLNCNDYLKAVEWLKKSDT 198
                 3489999999************943 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 1.2
                 HHHHHHHHHH....TT-HHHHHHHHHCTSHHHC-HHHHHHHHHH CS
      ANAPC3  26 ayllAlclyl....ngqykrAyellrkaklnskslgcrylfAqc 65 
                 + ++A+c+ +    +++ ++A++ ++++   ++ + c + +++ 
  EFC35228.1 233 ISYHAYCYEEgigtQKDPQKAFKMYQEN---ERLMDCKLGMGRM 273
                 4455777643222278888888888877...5556666655555 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.88
                 -HHHHHHHHHHHH CS
      ANAPC3  22 spedayllAlcly 34 
                  +e+ y+lA+ +y
  EFC35228.1 309 KNEAMYYLAEMYY 321
                 3566888899998 PP

>> Coatomer_E  Coatomer epsilon subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   8.7e-05     0.078     181     260 ..      39     118 ..      32     131 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 8.7e-05
                 THHHHHHHHHHHHHHHS---HHHHHHHHHHHH.HTT-HHHHHHHHHHHHHH-TT-HHHHHHHHHHHHHTT--HHHHHHHHH CS
  Coatomer_E 181 ekiqdAyyifqelsekykstplllngkAvvsl.llgryeeAeslLkeaLdkdakdeetLiNlvvaaqhlgkdaevsernls 260
                 ++++ A++i +++ e  ++t  +  ++      +l++ye+A + L+ aL+ d++++  L  l v+ ++ g  ++  ++ +s
  EFC35228.1  39 KEYEKALLILNQIIES-DPTKSIFLHQRYLTFkKLKNYEKAIEDLNRALELDPNNASYLNSLGVCYKEGGCVKKDWDKAIS 118
                 67899**********9.8888888887777662689*****************************9998876666666665 PP

>> TOM20_plant  Plant specific mitochondrial import receptor subunit TOM20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       2.1   1.9e+03      93     117 ..      38      62 ..      32      72 .. 0.81
   2 ?    8.8   0.0    0.0014       1.2      94     125 ..      73     104 ..      68     107 .. 0.91
   3 ?   -2.5   0.0         4   3.6e+03      99     121 ..     223     232 ..     199     271 .. 0.52

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2.1
                  HHHHHHHHHHHHHHHHH-TT-HHHH CS
  TOM20_plant  93 kenfekatqffqqavdedPdndlyr 117
                  ++++eka  +++q ++ dP + ++ 
   EFC35228.1  38 EKEYEKALLILNQIIESDPTKSIFL 62 
                  5689999999999999999988775 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.0014
                  HHHHHHHHHHHHHHHH-TT-HHHHHHHHHHHT CS
  TOM20_plant  94 enfekatqffqqavdedPdndlyrkslelaak 125
                  +n+eka + +++a + dP+n  y  sl ++ k
   EFC35228.1  73 KNYEKAIEDLNRALELDPNNASYLNSLGVCYK 104
                  699************************98876 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 4
                  HHHHHHHHHHH-TT-HHHHHHHH CS
  TOM20_plant  99 atqffqqavdedPdndlyrksle 121
                  a +++              ks +
   EFC35228.1 223 AFEYY-------------SKSNT 232
                  22222.............22222 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.047        42      15      33 ..      39      57 ..      25      59 .. 0.91
   2 ?   12.5   0.3   0.00013      0.11      13      35 ..      71      93 ..      67      97 .. 0.93
   3 ?   -1.6   0.0       3.4     3e+03      16      27 ..     284     295 ..     282     309 .. 0.83
   4 ?   -2.0   0.7       4.5     4e+03       2       9 ..     311     318 ..     310     321 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.047
                T-HHHHHHHHHHHHHHTTS CS
  Fis1_TPR_C 15 geYseArryvdalLeiEPe 33
                +eY++A+  +++++e +P 
  EFC35228.1 39 KEYEKALLILNQIIESDPT 57
                8**************9995 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 0.00013
                HHT-HHHHHHHHHHHHHHTTS-H CS
  Fis1_TPR_C 13 klgeYseArryvdalLeiEPenr 35
                kl++Y++A + +++ Le++P+n 
  EFC35228.1 71 KLKNYEKAIEDLNRALELDPNNA 93
                9*********************7 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 3.4
                 -HHHHHHHHHHH CS
  Fis1_TPR_C  16 eYseArryvdal 27 
                 +Y+++ +y+  +
  EFC35228.1 284 DYQKSFKYCTEV 295
                 89******9766 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 4.5
                 HHHHHHHH CS
  Fis1_TPR_C   2 eclYylAl 9  
                 e +YylA 
  EFC35228.1 311 EAMYYLAE 318
                 789***95 PP

>> SHNi-TPR  SHNi-TPR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.81   7.2e+02      22      36 ..      39      53 ..      38      55 .. 0.84
   2 ?   10.3   0.1    0.0004      0.36      16      30 ..      74      88 ..      73      88 .. 0.96
   3 ?   -2.4   0.0       3.9   3.5e+03      23      33 ..     185     195 ..     184     197 .. 0.83
   4 ?   -3.7   0.0       9.7   8.7e+03      23      29 ..     284     290 ..     284     296 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.81
    SHNi-TPR 22 eDlrkaLeLreqllp 36
                ++++kaL + +q+ +
  EFC35228.1 39 KEYEKALLILNQIIE 53
                69*****99999765 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.0004
    SHNi-TPR 16 nFpqAveDlrkaLeL 30
                n++ A+eDl++aLeL
  EFC35228.1 74 NYEKAIEDLNRALEL 88
                9*************8 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 3.9
    SHNi-TPR  23 DlrkaLeLreq 33 
                 D+ ka+e+  +
  EFC35228.1 185 DYLKAVEWLKK 195
                 9999**99765 PP

  == domain 4  score: -3.7 bits;  conditional E-value: 9.7
    SHNi-TPR  23 DlrkaLe 29 
                 D++k+ +
  EFC35228.1 284 DYQKSFK 290
                 9999966 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0         1   9.2e+02      13      29 ..      38      54 ..      33      55 .. 0.83
   2 ?    5.0   0.0     0.038        34      11      25 ..     108     122 ..     108     125 .. 0.89
   3 ?   -1.1   0.1       3.4   3.1e+03      10      25 ..     180     195 ..     179     195 .. 0.82
   4 ?   -2.3   0.0         8   7.2e+03      15      24 ..     219     228 ..     217     229 .. 0.82
   5 ?   -0.4   0.0         2   1.8e+03      14      25 ..     248     259 ..     245     259 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 1
         PPR 13 nGkleeAlelfkeMkek 29
                + ++e+Al ++++++e+
  EFC35228.1 38 EKEYEKALLILNQIIES 54
                5789********99886 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.038
         PPR  11 cknGkleeAlelfke 25 
                 c + ++++A++lf++
  EFC35228.1 108 CVKKDWDKAISLFER 122
                 7789*********97 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 3.4
         PPR  10 ycknGkleeAlelfke 25 
                 +  ++++ +A+e++k+
  EFC35228.1 180 CLNCNDYLKAVEWLKK 195
                 55688999****9986 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 8
         PPR  15 kleeAlelfk 24 
                 ++++A+e++ 
  EFC35228.1 219 DPRKAFEYYS 228
                 799****986 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 2
         PPR  14 GkleeAlelfke 25 
                  ++++A+++++e
  EFC35228.1 248 KDPQKAFKMYQE 259
                 5899******97 PP

>> SPO22  Meiosis protein SPO22/ZIP4 like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.2    0.0034         3      91     148 ..      32      87 ..      22      88 .. 0.85
   2 ?   -2.2   0.0       2.6   2.4e+03     261     274 ..     110     123 ..     102     124 .. 0.83
   3 ?   -0.3   0.0      0.66   5.9e+02      41      62 ..     175     196 ..     166     207 .. 0.85
   4 ?    1.6   0.0      0.17   1.6e+02      51      95 ..     284     321 ..     247     342 .. 0.73

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0034
       SPO22  91 arayleldqeesyekalkavell.qkeygkkehpsllllklkillkreadeeeieeale 148
                 a+  +   +e++yekal +++++ +++ +k++    ++l +k+l++ e   e++  ale
  EFC35228.1  32 AKSFY---TEKEYEKALLILNQIiESDPTKSIFLHQRYLTFKKLKNYEKAIEDLNRALE 87 
                 55566...89*************8889999999999*********99999888888876 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2.6
       SPO22 261 aknydeAaewyels 274
                 +k++d+A+ ++e s
  EFC35228.1 110 KKDWDKAISLFERS 123
                 68999999999876 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.66
       SPO22  41 niGksllskkkyeeavkWLqra 62 
                 ++G+  l++++y +av WL+++
  EFC35228.1 175 EYGLLCLNCNDYLKAVEWLKKS 196
                 5677788999999999999987 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.17
       SPO22  51 kyeeavkWLqraldilekqesesksssdlselrlsvlrllarayl 95 
                 +y+++ k+ ++ ++++        ++ d ++l++  + +la  y+
  EFC35228.1 284 DYQKSFKYCTEVFEYCI-------NTKDNQDLKNEAMYYLAEMYY 321
                 55555555555555555.......555668899999999998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.57
# Mc/sec: 1840.19
//
Query:       EFC35229.1  [L=291]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-05   24.6   0.2    5.6e-05   23.2   0.1    1.8  2  Mis12           Mis12 protein
  ------ inclusion threshold ------
      0.026   14.4   0.0      0.055   13.4   0.0    1.6  1  Endonuclease_7  Recombination endonuclease VII
      0.031   13.6   0.1       0.14   11.4   0.0    1.9  2  JMY             Junction-mediating and -regulatory protein
      0.042   14.0   0.1       0.23   11.6   0.1    2.1  2  TetR_C_4        YsiA-like protein, C-terminal region
      0.057   12.1   2.3      0.064   11.9   0.1    2.1  3  Dor1            Dor1-like family
      0.078   13.3   0.2         23    5.4   0.2    2.8  3  mCpol           minimal CRISPR polymerase domain
      0.096   12.8   0.1       0.17   12.0   0.1    1.4  1  Phage_RpbA      Phage RNA polymerase binding, RpbA


Domain annotation for each model (and alignments):
>> Mis12  Mis12 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       3.6   9.1e+03      53      70 ..      18      35 ..      12      39 .. 0.70
   2 !   23.2   0.1   2.2e-08   5.6e-05      16      85 ..     107     209 ..     104     256 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.6
                -HHHHHHHHHHHHHHHHH CS
       Mis12 53 steeieeGtakletllea 70
                s+ee++e +  l tll a
  EFC35229.1 18 SDEELKEQLGSLATLLAA 35
                567777777777777765 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 2.2e-08
                 HHHHHHHHHHHHHHHHHHHHH.........................................TTSTHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       Mis12  16 diinavndllyravdavekvL.................................dkkleedeeeekaaeesteeieeGtakletlleasvDknfdkfEl 81 
                 ++ n+v   ++ ++da+ ++                                  +k+ ++++  ++ +e +++ i+eG++k++t l++++Dk++++f +
  EFC35229.1 107 EVCNSVSGKANGCLDALSQIWdkfldngckkaaellpenlqtpantilewlkpaKKQVSSKDWIDNLTEITDNTIQEGVKKFKTQLQDALDKQVSNFMI 205
                 667777777777777777755666688888888888888888888888888887666777777999999****************************** PP

                 HHHH CS
       Mis12  82 yvlr 85 
                 ++l 
  EFC35229.1 206 FCLL 209
                 9985 PP

>> Endonuclease_7  Recombination endonuclease VII
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   2.1e-05     0.055      50      75 ..     100     125 ..      77     133 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.1e-05
                     -.EEEEEHHHHH.HHHTTT-HHHH.. CS
  Endonuclease_7  50 kvRgllCgsCNtalGklkdspealrr 75 
                      +R+ +C+ CN++ Gk++ + +al +
      EFC35229.1 100 VTREEICEVCNSVSGKANGCLDALSQ 125
                     589*****************999987 PP

>> JMY  Junction-mediating and -regulatory protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   5.6e-05      0.14      51     124 ..     128     201 ..     116     227 .. 0.87
   2 ?   -0.4   0.0      0.21   5.5e+02     184     212 ..     229     257 ..     211     274 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 5.6e-05
         JMY  51 eeeldelcrqleeyLgtaldicgkkilldvLfeededdaeeyfeslselrkkgleeelqrakeelrevlekhkk 124
                 ++ ld+ c++  e L   l++  ++il  +  ++++ ++++++++l e+  ++++e +++ k++l++ l+k+ +
  EFC35229.1 128 DKFLDNGCKKAAELLPENLQTPANTILEWLKPAKKQVSSKDWIDNLTEITDNTIQEGVKKFKTQLQDALDKQVS 201
                 56678899999999999999999999988888899999******************************998765 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.21
         JMY 184 gpkrvealqkeaeewqkkaeeavlsiqdl 212
                  pk++e ++ke+++ +++  ea l ++ +
  EFC35229.1 229 TPKQIEYIKKEFSKIRNHLVEACLLLESY 257
                 58999999999999999999998776655 PP

>> TetR_C_4  YsiA-like protein, C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.47   1.2e+03      38      83 ..      93     137 ..      72     152 .. 0.73
   2 ?   11.6   0.1   9.1e-05      0.23      69     119 ..     173     225 ..     140     238 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.47
                 HC-HHHHHHHHTTCCGSSHHHHHHHHHHHHHHHHHHHHHHHHHHHT CS
    TetR_C_4  38 sadkelaivtqlelrqsnlelrlkinevlkgyltlldeiiaeGkek 83 
                 ++  +  +vt+ e+    +++  k n  l +  ++ d+ + +G +k
  EFC35229.1  93 ETSLK-NAVTREEICEVCNSVSGKANGCLDALSQIWDKFLDNGCKK 137
                 44433.3578888888888889999999999999999999988765 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 9.1e-05
                 HHHHHHHHHHHHHHT..TSC-TT--HHHHHHHHHHHHHHHHHHHHHTTT-S-C CS
    TetR_C_4  69 yltlldeiiaeGkek..GefkeeldvrlarqlifGtldevvtnWvmkdqkydl 119
                   ++ d+ i+eG +k   ++++ ld ++   +if  ld   t+  ++++ y+ 
  EFC35229.1 173 LTEITDNTIQEGVKKfkTQLQDALDKQVSNFMIFCLLDSCTTTAQLAGKLYNY 225
                 457889999**988522678999*******************99888888875 PP

>> Dor1  Dor1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.26   6.6e+02      61      86 ..      77     102 ..      72     130 .. 0.61
   2 ?   -3.0   0.1      0.86   2.2e+03     139     170 ..     164     195 ..     160     202 .. 0.59
   3 ?   11.9   0.1   2.5e-05     0.064      30      84 ..     215     269 ..     210     284 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.26
        Dor1  61 qledLvlklpkLteectrfskkaeei 86 
                 ++ +L++++p L +e++ + k+a   
  EFC35229.1  77 HITELSSNIPSLLSEMETSLKNAVTR 102
                 56667777777777776666666433 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.86
        Dor1 139 istnpviqsiaaeveetvqelleqLiqkLrsp 170
                 +s+++ i+++ + +++t+qe +++   +L+  
  EFC35229.1 164 VSSKDWIDNLTEITDNTIQEGVKKFKTQLQDA 195
                 55566666666666666666666655555544 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 2.5e-05
        Dor1  30 iqdLarknyktlidaaealeairqelediraqledLvlklpkLteectrfskkae 84 
                 + +La k y+ +i++ +++e i +e+++ir++l +  l l+  ++      +k +
  EFC35229.1 215 TAQLAGKLYNYYITTPKQIEYIKKEFSKIRNHLVEACLLLESYYSHPMSTETKIK 269
                 679*******************************999988888776655555555 PP

>> mCpol  minimal CRISPR polymerase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       4.9   1.2e+04      28      53 ..      18      43 ..      12      45 .. 0.73
   2 ?    5.1   0.0     0.011        28       9      47 ..      62     100 ..      61     138 .. 0.88
   3 ?    5.4   0.2    0.0089        23      28      73 ..     181     226 ..     170     256 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.9
       mCpol 28 lskevkeaikklkkllkdelgasvif 53
                  +e+ke++ +l++ll  el  +v f
  EFC35229.1 18 SDEELKEQLGSLATLLAAELPDAVPF 43
                55788889999999888887666655 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.011
       mCpol   9 iGkklealllsndeeeleklskevkeaikklkkllkdel 47 
                 +Gk +e  ++  +++++ +ls+++   ++++++ lk+ +
  EFC35229.1  62 VGKVIELPFRLAAVNHITELSSNIPSLLSEMETSLKNAV 100
                 89*************************999999998765 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0089
       mCpol  28 lskevkeaikklkkllkdelgasvifaaGDsilakssleedllvel 73 
                 + + vk++  +l+++l +++++++if+  Ds + +++l  +l++ +
  EFC35229.1 181 IQEGVKKFKTQLQDALDKQVSNFMIFCLLDSCTTTAQLAGKLYNYY 226
                 45668888889999999999***********999997765444443 PP

>> Phage_RpbA  Phage RNA polymerase binding, RpbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   6.5e-05      0.17      20      60 ..     166     206 ..     152     245 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 6.5e-05
  Phage_RpbA  20 RkaWVlqisdeeaeklqaleqevrfelYkeiDkeVsdkwie 60 
                  k W+ ++++ + + +q   ++ + +l +++Dk+Vs+ +i 
  EFC35229.1 166 SKDWIDNLTEITDNTIQEGVKKFKTQLQDALDKQVSNFMIF 206
                 599*********************************99885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1038  (0.057895); expected 358.6 (0.02)
Passed bias filter:                      649  (0.0361983); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.56
# Mc/sec: 1554.99
//
Query:       EFC35230.1  [L=111]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       481  (0.026828); expected 358.6 (0.02)
Passed bias filter:                      311  (0.0173462); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.32s 00:00:00.78 Elapsed: 00:00:00.50
# Mc/sec: 673.85
//
Query:       EFC35231.1  [L=211]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.22   11.9   5.1      0.088   13.2   1.4    2.2  2  DUF5476   Family of unknown function (DUF5476)


Domain annotation for each model (and alignments):
>> DUF5476  Family of unknown function (DUF5476)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   1.4   4.9e-06     0.088       8      45 ..      53      93 ..      50     111 .. 0.78
   2 ?   -1.3   0.1      0.17     3e+03       6      40 ..     144     174 ..     140     189 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.9e-06
     DUF5476  8 kvPKvdtaqvkapePaPLteepkgvefGgdddd...sedet 45
                ++P+ d ++ k peP P+ +    v+ G+++++   +++ +
  EFC35231.1 53 QTPQLDLSAFKQPEPKPIDNAQPTVKLGTETKStgpTATLN 93
                69****************************99955444444 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.17
     DUF5476   6 KvkvPKvdtaqvkapePaPLteepkgvefGgdddd 40 
                 Kv +P  + ++v   +P   ++  ++  fG+ ++ 
  EFC35231.1 144 KVATPTEQKKNV--FNPF--ANTTSSSMFGTPSSR 174
                 666676666654..5554..666666667776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      253  (0.0141112); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 1177.91
//
Query:       EFC35232.1  [L=216]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-06   28.1   0.0    7.8e-06   25.7   0.0    2.0  2  VHL       VHL beta domain


Domain annotation for each model (and alignments):
>> VHL  VHL beta domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   0.0   4.4e-10   7.8e-06       8      63 ..      11      66 ..       4      80 .. 0.86
   2 ?   -0.1   0.0     0.048   8.6e+02       6      41 ..     152     187 ..     146     205 .. 0.78

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 4.4e-10
         VHL  8 ipvevvFcnrsprvvkplWidfeGePqsYeelkPgtgrrmttyvgHpWlFRDAetd 63
                 ++ ++F+n+ +  ++ +Wid+eG+ q+++ l+ g +   ++  +Hp++ R  +++
  EFC35232.1 11 HKCPIIFHNTLSEPIQMIWIDYEGNEQPFTVLNSGGKCCQQAGATHPFIMRRMNDE 66
                57889*******************************9999**********965554 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.048
         VHL   6 sripvevvFcnrsprvvkplWidfeGePqsYeelkP 41 
                  ++ v++  +n ++r  + + +d eG+ +s+    P
  EFC35232.1 152 GHELVDISIRNDTSRKYNVFRVDEEGNQTSHGYSAP 187
                 567889999999999999999999998877665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (216 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1264.57
//
Query:       EFC35233.1  [L=366]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.5e-12   44.3   5.5     0.0016   18.4   0.3    4.6  4  NHL       NHL repeat
    2.3e-06   27.4   0.3     0.0014   18.3   0.1    3.3  3  SGL       SMP-30/Gluconolactonase/LRE-like region


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.2   0.00075       6.7       8      23 ..      28      44 ..      28      48 .. 0.84
   2 !    9.9   0.0     9e-05       0.8       4      27 ..      87     109 ..      84     110 .. 0.76
   3 !    8.4   0.0   0.00025       2.3       1      23 [.     140     162 ..     140     166 .. 0.94
   4 !   18.4   0.3   1.8e-07    0.0016       1      27 [.     204     230 ..     204     231 .. 0.94

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00075
                EEE.TTTEEEEEECCCT CS
         NHL  8 avd.snGdiyVaDsenh 23
                +vd +nGd+y  D+ nh
  EFC35233.1 28 TVDpNNGDVYLVDYFNH 44
                5999*********7776 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 9e-05
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P +v v ++  +y++Ds nh++++
  EFC35233.1  87 PISVLV-DSTFVYITDSMNHCIRK 109
                 555555.5778***********97 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.00025
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 fn+P G a+  +G  +VaD  nh
  EFC35233.1 140 FNNPYGMALAADGTMFVADKANH 162
                 899*******************9 PP

  == domain 4  score: 18.4 bits;  conditional E-value: 1.8e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f +P+ v vdsn+++yV D++n+r+++
  EFC35233.1 204 FTNPNAVIVDSNNNVYVFDYGNFRIRK 230
                 7899*********************97 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0     0.026   2.4e+02       5      37 ..      27      59 ..      23      85 .. 0.77
   2 !   18.3   0.1   1.5e-07    0.0014     143     216 ..      92     173 ..      75     206 .. 0.71
   3 !    4.1   0.0    0.0033        29     186     214 ..     207     236 ..     193     252 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.026
         SGL  5 pvwdeeegaLlwvDilgqrihrldpatgketvl 37
                +++d+++g +++vD  +  + r+d  t+ ++ +
  EFC35233.1 27 CTVDPNNGDVYLVDYFNHMVRRIDVTTNISSIF 59
                678888999999999999999999888877765 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 1.5e-07
         SGL 143 pdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge........gepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                  d++ +Y++Ds++++i +++  ++  + ++      +++++        ++p G+a+ a+G ++vA  +++ ++r++pdG++
  EFC35233.1  92 VDSTFVYITDSMNHCIRKINKISNLVYTHAGSCGTSGSTNGntptaarfNNPYGMALAADGTMFVADKANHIIRRINPDGSV 173
                 58999**********999987444443333332233332226888888877****************************985 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.0033
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpd.G 214
                 p  ++vD+++nv+v  +g+ +++++d+  G
  EFC35233.1 207 PNAVIVDSNNNVYVFDYGNFRIRKIDNStG 236
                 667899***********9999999999855 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       423  (0.0235931); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 2060.25
//
Query:       EFC35234.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.022   12.6   5.5      0.024   12.5   5.5    1.0  1  Retinal     Retinal protein
       0.86    9.0   9.2          1    8.8   9.2    1.1  1  Endostatin  Collagenase NC10 and Endostatin
        2.4    6.8   5.9        2.4    6.7   5.9    1.0  1  Ndc1_Nup    Nucleoporin protein Ndc1-Nup


Domain annotation for each model (and alignments):
>> Retinal  Retinal protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   5.5     4e-06     0.024    1046    1117 ..      32     101 ..      15     155 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4e-06
     Retinal 1046 slptvqsspspplsprapsPpa...sprvlspptskkrtsppaqhklpsppkesspaqeklsspptqrteassps 1117
                     +v+++p pp+ p+ap  ++   + ++ spp ++ + +pp+q ++ ++p++ ++       +p+q++++    
  EFC35234.1   32 EEAQVNGQPQPPIGPQAPQQTQqtrQIQTNSPPRNRMNVTPPRQTQQNNTPPRNQTI-----YQPQQNENVIRNN 101 
                  56799************9887722245679****************99988533332.....2333333333333 PP

>> Endostatin  Collagenase NC10 and Endostatin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   9.2   0.00017         1      31     140 ..       2     113 ..       1     144 [. 0.46

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00017
  Endostatin  31 gdlYlrvrdgwrkvqlgelipllselekkenevaav..qps.Pvvksskerlvllearrktksskesvkake.keaskeeleekaekkveeseksltta 125
                 +++Yl+++   r++q +  ++  +e+  +ene a+v  qp+ P+  +  + +++++++ +t+s  +++ + + +++++++ +++ +++  + +++++  
  EFC35234.1   2 ENFYLKINRKARELQERFGVENGQENG-SENEEAQVngQPQpPIGPQAPQ-QTQQTRQIQTNSPPRNRMNVTpPRQTQQNNTPPRNQTIYQPQQNENVI 98 
                 579***********9555444444432.3333333301444244444444.333333333333333333333133333333333332222222222222 PP

  Endostatin 126 rraskkepeaaaets 140
                 r++++++ +   +++
  EFC35234.1  99 RNNQQANINPIRNNN 113
                 222222222222222 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   5.9   0.00041       2.4     373     478 ..      35     151 ..       2     203 .. 0.44

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00041
    Ndc1_Nup 373 pvkelprlsksplkkkddeifgnsltaeaspkssssskegvekalsslakspgqspsptarls....prarkllekaksrlls................ 451
                 +v+ +p+ +  p+  +         +++++ + +++s+ + +  ++++ +++++ ++p+++++    +++++++++++++ ++                
  EFC35234.1  35 QVNGQPQPPIGPQAPQ---------QTQQTRQIQTNSPPRNRMNVTPPRQTQQN-NTPPRNQTiyqpQQNENVIRNNQQANINpirnnnqnervmnhvp 123
                 3333333332222221.........11111111222222222222222222111.22222222222222233333333333332221111111111444 PP

    Ndc1_Nup 452 .keqkealsestikkkvekelaqllksp 478
                  ++ +   ++++++  v++ l+q+++ +
  EFC35234.1 124 iNNGQVVRHPQNQSLIVQPHLQQFNNAS 151
                 4555555555555555555555555543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1281  (0.0714485); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1293.79
//
Query:       EFC35235.1  [L=160]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.9e-22   78.1   9.3    3.1e-05   24.6   0.2    4.1  4  WD40         WD domain, G-beta repeat
    1.1e-07   32.1   0.0        1.1    9.8   0.0    4.1  4  PQQ_3        PQQ-like domain
  ------ inclusion threshold ------
      0.012   15.9   0.0        1.8    8.9   0.0    2.6  2  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
      0.016   14.2   0.0      0.068   12.1   0.0    1.8  1  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
      0.043   13.3   0.1      0.073   12.6   0.1    1.4  1  Tachylectin  Tachylectin
      0.047   13.7   0.0        2.4    8.2   0.0    2.4  2  BBS2_Mid     Ciliary BBSome complex subunit 2, middle region
      0.048   12.3   0.0      0.063   11.9   0.0    1.3  1  Nup160       Nucleoporin Nup120/160


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   5.3e-07    0.0014       4      38 .]      10      43 ..       7      43 .. 0.84
   2 !   24.6   0.2   1.2e-08   3.1e-05       1      37 [.      46      82 ..      46      82 .. 0.95
   3 !   17.2   0.5   2.8e-06    0.0072       4      38 .]      90     124 ..      87     124 .. 0.82
   4 !   20.6   0.1   2.2e-07   0.00057       1      34 [.     128     160 .]     128     160 .] 0.81

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 5.3e-07
                EEEEESS.SSEEEEEEETTSSE....EEEEETTSEEEEEE CS
        WD40  4 lrtltGH.ssvtslafspdgaw....lasGsdDgtvriWd 38
                 +++tGH +s++ l      ++    l sGs D t+r Wd
  EFC35235.1 10 SKEFTGHaKSISTL------QYfngkLYSGSHDATLRQWD 43
                578***********......665555679*99*******9 PP

  == domain 2  score: 24.6 bits;  conditional E-value: 1.2e-08
                TEEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  1 gqclrtltGH.ssvtslafspdgawlasGsdDgtvriW 37
                g+cl +++GH ++++++ +sp+g    +GsdDg +r W
  EFC35235.1 46 GSCLFVFKGHgKFISAMITSPEGVI-YTGSDDGDIRSW 82
                68********999***********9.89********99 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 2.8e-06
                 EEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 l+ ++GH + ++sl  +  ++ l sGs D+ +r Wd
  EFC35235.1  90 LHFFKGHtKTISSLTLHGKKH-LYSGSFDNDIRKWD 124
                 789****999****4444444.59***********9 PP

  == domain 4  score: 20.6 bits;  conditional E-value: 2.2e-07
                 TEEEEEEESSSS.EEEEEEETTSSEEEEEETTSEE CS
        WD40   1 gqclrtltGHss.vtslafspdgawlasGsdDgtv 34 
                 g+cl+t++GH++ vt++a+  d  +  s+s D+t+
  EFC35235.1 128 GECLQTFRGHTDiVTGIAVKNDYIY--SSSADKTI 160
                 69********7757***77666666..7777**98 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0     0.011        29      12      38 ..      18      44 ..      10      45 .. 0.79
   2 !    9.8   0.0   0.00043       1.1      10      38 ..      55      84 ..      52      86 .. 0.79
   3 !    7.5   0.0    0.0023       5.8      12      40 .]      98     127 ..      93     127 .. 0.86
   4 ?    4.4   0.0     0.021        55      10      33 ..     137     160 .]     133     160 .] 0.85

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.011
       PQQ_3 12 pvnsspavdgglvyvgtgdGtlyAlDa 38
                +  s++ + +g++y g++d tl+  D+
  EFC35235.1 18 KSISTLQYFNGKLYSGSHDATLRQWDP 44
                5556777889************98876 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00043
       PQQ_3 10 pgpvnsspavd.gglvyvgtgdGtlyAlDa 38
                +g+  s++ ++ +g++y+g++dG +++  a
  EFC35235.1 55 HGKFISAMITSpEGVIYTGSDDGDIRSWAA 84
                5667777877757***********998766 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0023
       PQQ_3  12 pvnsspavdg.glvyvgtgdGtlyAlDaet 40 
                 ++ ss+++ g  ++y g+ d+ ++  Daet
  EFC35235.1  98 KTISSLTLHGkKHLYSGSFDNDIRKWDAET 127
                 6679999999568***************98 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.021
       PQQ_3  10 pgpvnsspavdgglvyvgtgdGtl 33 
                 + +++++ av ++++y ++ d t+
  EFC35235.1 137 HTDIVTGIAVKNDYIYSSSADKTI 160
                 568999**********99999875 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0    0.0066        17      49      88 ..      67     104 ..      26     108 .. 0.83
   2 ?    8.9   0.0   0.00072       1.8      38      81 ..      97     139 ..      94     148 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0066
  ANAPC4_WD40  49 dgklLavaysdgevrlldaesgkvvhslsvksekavtclg 88 
                  +g ++  + +dg +r   ae + ++h ++ +++ ++++l+
   EFC35235.1  67 EG-VIYTGSDDGDIRSWAAERQVILHFFKGHTK-TISSLT 104
                  44.6788999***********999999998888.588876 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00072
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                   ++++sL  + + k L  +  d+ +r  dae+g+++++++ +++
   EFC35235.1  97 TKTISSLTLHGK-KHLYSGSFDNDIRKWDAETGECLQTFRGHTD 139
                  566777777766.45789999*****************998877 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   2.7e-05     0.068     173     292 ..      41     143 ..      16     155 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 2.7e-05
    Ge1_WD40 173 sveeieegllkieehsliveaafspdGtalatasedGevkffqvyledeeeprCLheWkPhdGkslssllfldnhkeesdeqfWrfaitgadnnselkl 271
                 + +   + l+ ++ h + ++a++++   ++ t s dG ++ +      +e++  Lh +k h  k++ssl +             +++  g+ +n +++ 
  EFC35235.1  41 QWDPSGSCLFVFKGHGKFISAMITSPEGVIYTGSDDGDIRSWA-----AERQVILHFFKGHT-KTISSLTLHG----------KKHLYSGSFDN-DIRK 122
                 5555566778889998666666554445788999999999885.....57888999999995.9999997533..........25666777766.7999 PP

    Ge1_WD40 272 WscelWtClqtikfapsiess 292
                 W +e+ +Clqt + +++i + 
  EFC35235.1 123 WDAETGECLQTFRGHTDIVTG 143
                 ***********9998887765 PP

>> Tachylectin  Tachylectin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   2.8e-05     0.073      99     163 ..      27      92 ..      24     131 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.8e-05
                  T.EEEEE---SSTTS-HHHH-EE.EESSSGGG-.SEEEE-TT--EEEEE.TTEEEEES--SSTT--H CS
  Tachylectin  99 dGeLykgppPsdeetsWeavatk.vidtgwkdf.dslfadpdGvlYavtstGrlvkrakPaevgddw 163
                  +G+Ly g + +    +W+ ++ +  + +g+++f ++++  p+Gv+Y  + +G+++ +a   +v  ++
   EFC35235.1  27 NGKLYSG-SHDATLRQWDPSGSClFVFKGHGKFiSAMITSPEGVIYTGSDDGDIRSWAAERQVILHF 92 
                  5888876.55667789*6555551567888776378999*************999888766655444 PP

>> BBS2_Mid  Ciliary BBSome complex subunit 2, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.029        74      15      32 ..      70      87 ..      48     102 .. 0.80
   2 ?    8.2   0.0   0.00095       2.4       5      51 ..     101     149 ..      97     160 .] 0.81

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.029
    BBS2_Mid 15 Lvvgsddfeirvfkeeel 32
                +  gsdd +ir +  e+ 
  EFC35235.1 70 IYTGSDDGDIRSWAAERQ 87
                678********9998853 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00095
    BBS2_Mid   5 advdgdgeneLvvgsddfeirvfkee..elvaeitetekvvslarleke 51 
                 + ++ +g+++L  gs d++ir ++ e  e +++++ +  +v+ ++++++
  EFC35235.1 101 SSLTLHGKKHLYSGSFDNDIRKWDAEtgECLQTFRGHTDIVTGIAVKND 149
                 6677899****************98866899999988888877777665 PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   2.5e-05     0.063     219     256 ..      90     134 ..      60     158 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.5e-05
                 EEEET............TTTEEEEEETT-EEEEEETTTTEEEEEE CS
      Nup160 219 ldvavavvei.......gqtylfalsrdgkLrvWnlltgkclati 256
                 l+++ + +++       g+++l++ s d+ +r W+ +tg cl t+
  EFC35235.1  90 LHFFKGHTKTissltlhGKKHLYSGSFDNDIRKWDAETGECLQTF 134
                 55555555555555566*************************994 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       350  (0.0195214); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 924.43
//
Query:       EFC35236.1  [L=116]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       777  (0.0433376); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 752.57
//
Query:       EFC35237.1  [L=130]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1085  (0.0605165); expected 358.6 (0.02)
Passed bias filter:                      649  (0.0361983); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.27s 00:00:00.70 Elapsed: 00:00:00.43
# Mc/sec: 901.23
//
Query:       EFC35238.1  [L=243]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       514  (0.0286686); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.55
# Mc/sec: 1334.68
//
Query:       EFC35239.1  [L=351]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-24   85.0  23.7      8e-11   42.0   6.0    4.2  4  LRR_4     Leucine Rich repeats (2 copies)
    1.5e-19   70.2   5.0    1.5e-14   53.8   1.9    2.3  2  LRR_9     Leucine-rich repeat
    1.1e-14   54.0  22.3    2.4e-07   30.4   4.8    4.0  3  LRR_8     Leucine rich repeat
    2.4e-06   27.2  18.5      0.017   15.1   0.3    6.1  7  LRR_6     Leucine Rich repeat
    0.00024   21.2  18.9          4    8.4   0.6    6.3  6  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   3.0     6e-10   2.1e-06       1      44 []     135     177 ..     135     177 .. 0.94
   2 !   42.0   6.0   2.2e-14     8e-11       2      43 ..     180     220 ..     179     221 .. 0.96
   3 !   23.3   0.1   1.7e-08   6.1e-05       2      38 ..     227     266 ..     226     272 .. 0.87
   4 ?    0.7   0.0      0.22   7.9e+02      19      29 ..     275     285 ..     271     285 .. 0.81

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 6e-10
                 SS--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGGXX CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeLkn 44 
                 + L+ L+L +N +t+i++l+ l++L+ L+L++N lit++++L+n
  EFC35239.1 135 TELKALWLEGNAITKIENLGHLDKLRCLYLNQN-LITTIENLEN 177
                 679***************************777.*******986 PP

  == domain 2  score: 42.0 bits;  conditional E-value: 2.2e-14
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeLk 43 
                 nL++L+Ls+N++t +++le +p+L++L+L gNn+i+++d+L+
  EFC35239.1 180 NLQTLNLSSNRITVVENLECCPQLETLNL-GNNKISSIDSLS 220
                 9****************************.*99******997 PP

  == domain 3  score: 23.3 bits;  conditional E-value: 1.7e-08
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38 
                 +L vLdLs+N + d +    l++lp+L++L+L gN+++++
  EFC35239.1 227 RLSVLDLSSNEIDDAGIvdiLSQLPKLTVLYLKGNPFVGK 266
                 5889**********999998889*********99*77655 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.22
                 HHH-TT--EEE CS
       LRR_4  19 leklpnLkeLd 29 
                 ++klp+L++Ld
  EFC35239.1 275 ISKLPHLTYLD 285
                 4579*****98 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.3   1.2e-07   0.00043      16      83 ..     110     175 ..      93     180 .. 0.74
   2 !   53.8   1.9   4.3e-18   1.5e-14      31     156 ..     169     295 ..     169     311 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 1.2e-07
       LRR_9  16 inairereldlrgykipvienlGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegl 83 
                   +  +  l l+   + vienl      + ++ l  n i k++++ +l +l++l+ln+n i+ i+ +l
  EFC35239.1 110 QTPYLNDKLFLHHRGFRVIENLELY-TELKALWLEGNAITKIENLGHLDKLRCLYLNQNLITTIE-NL 175
                 5555555566666667789999764.4678999999***********************999885.44 PP

  == domain 2  score: 53.8 bits;  conditional E-value: 4.3e-18
       LRR_9  31 ipvienlGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegle.evlPnleelvltnnelqeladldPlaslkklellsllknp.vtn 127
                 i++ienl   l  + t++ls n i  ++++    +l+tl l nn+i  i    +   l +l+ l l++ne+++ + +d l +l+kl++l l  np v +
  EFC35239.1 169 ITTIENLEN-LVNLQTLNLSSNRITVVENLECCPQLETLNLGNNKISSIDSLSSlCKLNRLSVLDLSSNEIDDAGIVDILSQLPKLTVLYLKGNPfVGK 266
                 578999975.66899*********************************97633314588999999******************************4456 PP

       LRR_9 128 kkeyrlyviyklkqlrlldfrkvklkere 156
                  k+yr+  i kl++l+ ld + v ++er 
  EFC35239.1 267 TKNYRKTFISKLPHLTYLDDKPVSKDERR 295
                 789**********************9997 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.5   8.2   1.1e-09   3.9e-06       2      61 .]     136     191 ..     135     191 .. 0.93
   2 !   30.4   4.8   6.7e-11   2.4e-07       1      60 [.     201     262 ..     201     263 .. 0.91
   3 ?    0.6   0.0      0.13   4.8e+02      18      31 ..     272     285 ..     266     285 .. 0.66

  Alignments for each domain:
  == domain 1  score: 26.5 bits;  conditional E-value: 1.1e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+ L L  N +t+++     +l +L+ L+L++Nl+tt++   +++L +L+ L+Ls+Nr+
  EFC35239.1 136 ELKALWLEGNAITKIE--NLGHLDKLRCLYLNQNLITTIE--NLENLVNLQTLNLSSNRI 191
                 699999999***9996..5899*****************6..****************98 PP

  == domain 2  score: 30.4 bits;  conditional E-value: 6.7e-11
                 TT-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G..GGGGGGTT--S-.EEE--SS- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsgNr 60 
                 p+L++L+L nN+++s+d  +    l++L vLdLs+N+++   +  + +s+Lp+L+ L+L gN+
  EFC35239.1 201 PQLETLNLGNNKISSIDSLSSLCkLNRLSVLDLSSNEIDDagI-VDILSQLPKLTVLYLKGNP 262
                 79***************9766655***************9866.699***************8 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.13
                 TTSSTT-TT--EEE CS
       LRR_8  18 deaFkglsnLkvLd 31 
                 +++ ++l++L++Ld
  EFC35239.1 272 KTFISKLPHLTYLD 285
                 45556677777775 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       2.6   9.3e+03       5      16 ..     137     148 ..     137     149 .. 0.82
   2 ?   -0.8   0.2      0.62   2.2e+03       4      16 ..     158     170 ..     157     171 .. 0.88
   3 !    9.5   0.7    0.0003       1.1       4      16 ..     180     192 ..     177     194 .. 0.90
   4 !    7.8   0.2    0.0011       3.9       2      16 ..     200     214 ..     199     216 .. 0.90
   5 !   15.1   0.3   4.8e-06     0.017       3      21 ..     226     244 ..     224     247 .. 0.86
   6 ?    2.1   0.0     0.071   2.6e+02       3      14 ..     251     262 ..     249     266 .. 0.85
   7 ?    0.5   0.1      0.23   8.2e+02       2       9 ..     278     285 ..     277     285 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.6
       LRR_6   5 LteLdLsgNdIg 16 
                 L++L L gN I+
  EFC35239.1 137 LKALWLEGNAIT 148
                 778889999997 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.62
       LRR_6   4 hLteLdLsgNdIg 16 
                 +L+ L L+ N I+
  EFC35239.1 158 KLRCLYLNQNLIT 170
                 699*******998 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.0003
       LRR_6   4 hLteLdLsgNdIg 16 
                 +L++L+Ls+N I+
  EFC35239.1 180 NLQTLNLSSNRIT 192
                 8**********98 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.0011
       LRR_6   2 nthLteLdLsgNdIg 16 
                 ++ L++L+L  N+I+
  EFC35239.1 200 CPQLETLNLGNNKIS 214
                 789**********97 PP

  == domain 5  score: 15.1 bits;  conditional E-value: 4.8e-06
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 + L  LdLs+N+I+D+G+ 
  EFC35239.1 226 NRLSVLDLSSNEIDDAGIV 244
                 56889************86 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.071
       LRR_6   3 thLteLdLsgNd 14 
                 ++Lt L L+gN 
  EFC35239.1 251 PKLTVLYLKGNP 262
                 79*********7 PP

  == domain 7  score: 0.5 bits;  conditional E-value: 0.23
       LRR_6   2 nthLteLd 9  
                  +hLt+Ld
  EFC35239.1 278 LPHLTYLD 285
                 58*****9 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.87   3.1e+03       2      13 ..     137     148 ..     136     154 .. 0.80
   2 ?    2.7   1.0     0.082   2.9e+02       1      15 [.     158     172 ..     158     178 .. 0.78
   3 !    8.4   0.6    0.0011         4       1      14 [.     180     193 ..     180     200 .. 0.82
   4 !    7.9   1.0    0.0016       5.8       1      18 [.     202     219 ..     202     225 .. 0.73
   5 ?    3.7   0.0     0.037   1.3e+02       2      13 ..     228     239 ..     227     251 .. 0.76
   6 !    5.7   0.0    0.0083        30       1      18 [.     252     269 ..     252     278 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.87
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L L++n ++
  EFC35239.1 137 LKALWLEGNAIT 148
                 899*****9775 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.082
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +Lr L+L++n ++ +
  EFC35239.1 158 KLRCLYLNQNLITTI 172
                 79********98644 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0011
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL++L+Ls+n+++ 
  EFC35239.1 180 NLQTLNLSSNRITV 193
                 8*********9964 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0016
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L+L+nn ++++ + 
  EFC35239.1 202 QLETLNLGNNKISSIDSL 219
                 59*********9544443 PP

  == domain 5  score: 3.7 bits;  conditional E-value: 0.037
       LRR_1   2 LrhLdLsnnpll 13 
                 L +LdLs+n ++
  EFC35239.1 228 LSVLDLSSNEID 239
                 889******984 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.0083
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L+L +np+ g+++n
  EFC35239.1 252 KLTVLYLKGNPFVGKTKN 269
                 79*********9888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1358  (0.0757432); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 2045.29
//
Query:       EFC35240.1  [L=215]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-72  245.1   0.0    1.2e-72  244.9   0.0    1.0  1  FTHFS     Formate--tetrahydrofolate ligase


Domain annotation for each model (and alignments):
>> FTHFS  Formate--tetrahydrofolate ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  244.9   0.0   6.6e-77   1.2e-72     345     554 .]       2     215 .]       1     215 [] 0.96

  Alignments for each domain:
  == domain 1  score: 244.9 bits;  conditional E-value: 6.6e-77
                 TTS--HHHHHHHHHHHHHHHHHHCTTT--EEEEEE--TT--HHHHHHHHHHH.HCTTSEEEEE-HHHHGGGGGHHHHHHHHHHCC...--.---SS-TT CS
       FTHFS 345 lkeenlealekGlanlekhienvkkfgvpvvvainkfktDteaelelvkela.eakavevalsevwakGgeGalelaeavveale...ekefkflYdle 439
                 +++ ++ea+++G+anl +hi+n++kfgvpvvv++n+f+tD+++e+e+v +l+ ea+a +++ s+++++Gg+Ga+++aea+v++++   + +fk+lYd +
  EFC35240.1   2 VTQPDVEAVKTGFANLGRHIANMRKFGVPVVVCVNQFTTDSAEEIETVVRLSkEAGADDCVPSNHFSEGGKGAVAIAEAIVRVCQdksKMNFKPLYDIN 100
                 6789**********************************************997888999**************************753366******** PP

                 S-HHHHHHHHHHHTT--SEEEE-HHHHHHHHHHHHTTCTTS-EEEE--SSSSSSSTT--SS--S-EEEEEEEEEETTTTEEEEESST--SS----SS-G CS
       FTHFS 440 lsieekietiakeiYgadgvelseeakkklkklekqgldklpvciaKtqySlsddpklkgapegftltvrevrlsaGagfivalageimtmPGlpkkpa 538
                  si+ekietiakeiYga+gve+ e+a+k+++kl+k   +k+++c aKtqyS+s+d+klkgap+gf l+++++rl +Gag++v+++g+i+ +PGlp++pa
  EFC35240.1 101 ISIKEKIETIAKEIYGAAGVEYAEAAEKEIQKLDKL-PEKYSICFAKTQYSFSHDEKLKGAPSGFILPIKSIRLYSGAGLLVPFCGDISALPGLPTRPA 198
                 *********************************998.799*********************************************************** PP

                 GGC-EE-TT.SEEES-- CS
       FTHFS 539 aekidvdee.gkieGlf 554
                 +  id+d e ++++Glf
  EFC35240.1 199 YLLIDIDPEtEEVKGLF 215
                 *******999*****98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.36s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1190.42
//
Query:       EFC35241.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.31   10.1  28.7       0.54    9.3  27.5    1.8  2  ABC2_membrane_3  ABC-2 family transporter protein


Domain annotation for each model (and alignments):
>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3  27.5     3e-05      0.54     165     283 ..      13     127 ..       3     202 .. 0.71
   2 ?   -1.1   1.2     0.046   8.2e+02     162     180 ..     186     205 ..     161     217 .. 0.63

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 3e-05
  ABC2_membrane_3 165 gliliilifitasfiavsiveEkes..rikelqlvsgvsplqywlskilgdflvyllqlllill.lafglgipfgnlglllllfllfglayial 255
                      +++++ +++i+++  ++ + +E e+  r  ++    g++ + y+lsk l++ +v +++++ +++ ++ +  +p +n+++l   ++l ++a  ++
       EFC35241.1  13 SFLVLAIALISIMRGLRVFGFEIENfkRESHV----GLNSWMYFLSKDLISIFVIAVISFSTTFgMLSA--LPHTNFFILYAIVFLTIMAGFPI 100
                      23333334444444444334444441144555....8**********7777777777777665537777..*********************** PP

  ABC2_membrane_3 256 gyllsslfknsetaqilifivilllsgf 283
                      gy ls++f+ +  aq+++ +v +++  f
       EFC35241.1 101 GYTLSFFFDPQ-IAQLAAALVVVVFYSF 127
                      ********966.4455444444422222 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.046
  ABC2_membrane_3 162 flvg.liliilifitasfia 180
                       +++ ++++++++i+++  +
       EFC35241.1 186 EAISfYFYALFFWIVVFRYM 205
                      33333555555555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1657.01
//
Query:       EFC35242.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0011   18.8   6.1     0.0017   18.2   6.1    1.3  1  C1_1          Phorbol esters/diacylglycerol binding domain (C
  ------ inclusion threshold ------
      0.023   15.0   4.4      0.054   13.8   4.4    1.6  1  zf-Di19       Drought induced 19 protein (Di19), zinc-binding
      0.073   13.1   0.4      0.088   12.8   0.4    1.3  1  HypA          Hydrogenase/urease nickel incorporation, metall
       0.22   11.6   3.4       0.39   10.9   3.4    1.4  1  Zf_RING       KIAA1045 RING finger
       0.55   10.6   7.0        1.2    9.6   7.0    1.5  1  zf-RING-like  RING-like domain
       0.55   10.2   6.4        1.2    9.1   6.4    1.6  1  PHD           PHD-finger
       0.91    9.6   6.0       0.58   10.3   0.6    2.4  2  zf-ACC        Acetyl-coA carboxylase zinc finger domain


Domain annotation for each model (and alignments):
>> C1_1  Phorbol esters/diacylglycerol binding domain (C1 domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   6.1   6.6e-07    0.0017       7      44 ..      82     116 ..      72     123 .. 0.86

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.6e-07
                 --SS--B-TTT-SB--SSSS-EEEETTT--EE-CCCCT CS
        C1_1   7 nfkqptfCkhCgeflwgkekqglkCswCkllvHkkChe 44 
                 ++k  + C+hC++     +++ +kC +C+ ++H+kC+ 
  EFC35242.1  82 SVKTRGLCEHCKNVH---SLTPIKCPACSSYIHQKCFV 116
                 5688999*****999...******************95 PP

>> zf-Di19  Drought induced 19 protein (Di19), zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   4.4   2.1e-05     0.054      12      50 ..      83     119 ..      79     124 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.1e-05
     zf-Di19  12 ltvkeLveHvedeHrveskevvCPvCaekvtkdlvaHlt 50 
                 +++  L+eH+++ H+   ++  CP C++++ +  +  ++
  EFC35242.1  83 VKTRGLCEHCKNVHSL--TPIKCPACSSYIHQKCFVDFH 119
                 56789*******9976..689******999876555333 PP

>> HypA  Hydrogenase/urease nickel incorporation, metallochaperone, hypA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.4   3.4e-05     0.088      65      95 ..      81     109 ..      28     116 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.4e-05
                 EEE--EEEETTTS-EEECHHHHHS-TTTSSS CS
        HypA  65 eevpvkvrCreCgkefeleekalrCpkCgsa 95 
                 ++v+ +  C++C++  +l+   ++Cp+C+s 
  EFC35242.1  81 SSVKTRGLCEHCKNVHSLT--PIKCPACSSY 109
                 5789999******999988..469****986 PP

>> Zf_RING  KIAA1045 RING finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   3.4   0.00015      0.39       3      36 ..      84     117 ..      82     123 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00015
     Zf_RING   3 eedelCeiCevytaeelypCRvCtkvfHegClrk 36 
                 ++  lCe C+   + + ++C  C+   H++C+  
  EFC35242.1  84 KTRGLCEHCKNVHSLTPIKCPACSSYIHQKCFVD 117
                 66789**************************976 PP

>> zf-RING-like  RING-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   7.0   0.00045       1.2       1      31 [.      89     118 ..      89     123 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00045
  zf-RING-like   1 CeaCkeiv.tqGvrCsnesCnvrlHvdCfqhy 31 
                   Ce Ck++  +  ++C+   C++ +H++Cf  +
    EFC35242.1  89 CEHCKNVHsLTPIKCP--ACSSYIHQKCFVDF 118
                   ******9736789***..***********776 PP

>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   6.4   0.00047       1.2       2      30 ..      89     115 ..      88     123 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00047
                 BTTTTSTTSTTSCEEEETTTSCEEETTTS CS
         PHD   2 CavCkkksdeeeelvqCdgCkrwfHqkCl 30 
                 C+ Ck+   ++ + + C  C++  HqkC 
  EFC35242.1  89 CEHCKN--VHSLTPIKCPACSSYIHQKCF 115
                 999998..678999**************6 PP

>> zf-ACC  Acetyl-coA carboxylase zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.5      0.12   3.1e+02       4       9 ..      89      94 ..      89      95 .. 0.87
   2 ?   10.3   0.6   0.00023      0.58       2      14 ..     101     113 ..     101     117 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.12
      zf-ACC  4 CpsCge 9 
                C++C++
  EFC35242.1 89 CEHCKN 94
                ****98 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00023
      zf-ACC   2 tKCpsCgemlykk 14 
                 +KCp+C++ +++k
  EFC35242.1 101 IKCPACSSYIHQK 113
                 8*******99998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       854  (0.0476323); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.53u 0.34s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 724.99
//
Query:       EFC35243.1  [L=152]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1485  (0.0828267); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.35s 00:00:00.92 Elapsed: 00:00:00.54
# Mc/sec: 847.88
//
Query:       EFC35244.1  [L=237]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-08   34.3   0.2       0.26   11.4   0.0    4.4  4  NHL       NHL repeat
    8.6e-06   26.0  30.7    5.9e-05   23.4   7.4    3.3  3  EGF_2     EGF-like domain
      0.003   17.2   0.0     0.0045   16.6   0.0    1.5  1  SGL       SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.088   13.5   5.0      0.088   13.5   5.0    4.0  4  hEGF      Human growth factor-like EGF
       0.56   10.6  24.0       0.62   10.4   3.4    3.6  3  EGF       EGF-like domain
        2.9    8.2  21.9        1.9    8.8   3.4    2.3  2  DSL       Delta serrate ligand


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.0   8.6e-05      0.26       1      25 [.       4      28 ..       4      29 .. 0.93
   2 !    7.6   0.0    0.0014       4.2       1      23 [.      65      87 ..      65      90 .. 0.90
   3 !    9.2   0.0   0.00042       1.3       1      25 [.     125     148 ..     125     149 .. 0.89
   4 ?    0.2   0.0       0.3     9e+02       3      13 ..     206     216 ..     204     217 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 8.6e-05
                BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrv 25
                +n P+G+ v+++Gdiy +D+ nh +
  EFC35244.1  4 LNLPNGLFVTDGGDIYFTDTLNHKI 28
                789*****************99988 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0014
                BSSEEEEEEETTTEEEEEECCCT CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenh 23
                +n P G++v  +G i+ +Ds+++
  EFC35244.1 65 LNTPKGLTVAEDGTIIFTDSGSN 87
                689*************9998875 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00042
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 f +P+G+ + s++++++aD +n  +
  EFC35244.1 125 FDDPAGLFL-SGNELLIADAKNGLI 148
                 788999999.8*********99877 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.3
                 SEEEEEEETTT CS
         NHL   3 yPhGvavdsnG 13 
                 y++Gva +s++
  EFC35244.1 206 YCSGVASNSSN 216
                 899****9765 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   1.5      0.23     7e+02      23      32 .]     155     164 ..     154     164 .. 0.93
   2 !   23.4   7.4     2e-08   5.9e-05       6      32 .]     177     202 ..     173     202 .. 0.87
   3 !   13.4   6.4   2.5e-05     0.076       4      27 ..     213     236 ..     207     237 .] 0.77

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.23
       EGF_2  23 CdsgyqGktC 32 
                 C++gy G tC
  EFC35244.1 155 CPTGYGGFTC 164
                 *********9 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 2e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ +G+C++ +  C+Cds+++G++C
  EFC35244.1 177 SVCSRNGKCIDYN-TCKCDSNHFGAYC 202
                 68*******8555.9************ PP

  == domain 3  score: 13.4 bits;  conditional E-value: 2.5e-05
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgy 27 
                 + ++ C+ hG Cv+  + C+C +g 
  EFC35244.1 213 NsSNVCSRHGRCVEY-NTCVCAPGS 236
                 25899*******944.48***8875 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   1.5e-06    0.0045     132     219 ..       3     101 ..       1     153 [. 0.83

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.5e-06
         SGL 132 dltipNGlawspdgktlYlaDsltrkiwaydvdaegg.klsnrrvfadlkkge...........gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 +l+ pNGl +  dg  +Y++D+l++ki  +  ++ +  ++    v a+++              ++p Gl+v ++G ++ +  g++ ++ ++ dGk i+
  EFC35244.1   3 KLNLPNGL-FVTDGGDIYFTDTLNHKIRLVTASTGKIsTIAGNGVRATTESLSkdgglptsaslNTPKGLTVAEDGTIIFTDSGSNYIRYVSSDGKTIN 100
                 67899999.56799999*********9988886544302333333344443337889999999988*****************************9987 PP

         SGL 219 e 219
                  
  EFC35244.1 101 I 101
                 6 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   1.4       0.8   2.4e+03       9      16 ..     157     164 ..     153     165 .. 0.63
   2 ?    7.8   4.9    0.0017       5.2       1      19 [.     179     194 ..     179     195 .. 0.90
   3 ?   -1.9   0.2         2   6.1e+03       4      10 ..     199     205 ..     197     211 .. 0.62
   4 ?   13.5   5.0   2.9e-05     0.088       1      21 [.     218     235 ..     218     235 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.8
                 ..-SS.-E CS
        hEGF   9 dgvggykC 16 
                  g+gg++C
  EFC35244.1 157 TGYGGFTC 164
                 46677777 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0017
                 --TT-EES..-SS.-EE-- CS
        hEGF   1 CnngGtCidgvggykCiCp 19 
                 C+ +G Ci   + ++C C+
  EFC35244.1 179 CSRNGKCI---DYNTCKCD 194
                 999*****...8899***8 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2
                 T-EES.. CS
        hEGF   4 gGtCidg 10 
                 g+ C+++
  EFC35244.1 199 GAYCENT 205
                 5567743 PP

  == domain 4  score: 13.5 bits;  conditional E-value: 2.9e-05
                 --TT-EES..-SS.-EE--TT CS
        hEGF   1 CnngGtCidgvggykCiCpPG 21 
                 C+ +G+C+     ++C+C+PG
  EFC35244.1 218 CSRHGRCV---EYNTCVCAPG 235
                 99******...7899*****9 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   1.1      0.14   4.3e+02      24      30 ..     155     161 ..     153     165 .. 0.73
   2 ?    9.5   4.6   0.00041       1.2       4      31 ..     175     200 ..     168     201 .. 0.86
   3 ?   10.4   3.4   0.00021      0.62       3      27 ..     215     235 ..     213     237 .] 0.88

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.14
                 ECTTEES CS
         EGF  24 CpeGytG 30 
                 Cp+Gy G
  EFC35244.1 155 CPTGYGG 161
                 8888866 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00041
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 n+  Cs +G+C+d+     tC+C++  +G+
  EFC35244.1 175 NTsvCSRNGKCIDYN----TCKCDSNHFGA 200
                 5578***********....*****998886 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00021
                 STTSTTT-EEEEETTTEEEEEECTT CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeG 27 
                 +n Cs +G+Cv++     tC C++G
  EFC35244.1 215 SNVCSRHGRCVEYN----TCVCAPG 235
                 466***********....******9 PP

>> DSL  Delta serrate ligand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   3.4   0.00065       1.9      15      51 ..     149     184 ..     140     191 .. 0.87
   2 ?    3.3  12.6     0.033     1e+02      19      52 ..     191     224 ..     186     236 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00065
                 EEEEEEE-TTEESSSS-EE----EETTEEEEE-TTS- CS
         DSL  15 ysvrvkCdenYygekCskfCrprddkfghytCdenGk 51 
                  s++++C + Y g +C+ +C +  ++++   C++nGk
  EFC35244.1 149 RSIKATCPTGYGGFTCKPICYDIMATNTS-VCSRNGK 184
                 57999******************999777.9*****8 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.033
                 EEE-TTEESSSS-E.E----EETTEEEEE-TTS-E CS
         DSL  19 vkCdenYygekCsk.fCrprddkfghytCdenGkk 52 
                 +kCd+n++g+ C++ +C+    + +   C+++G+ 
  EFC35244.1 191 CKCDSNHFGAYCENtYCSGVASN-SSNVCSRHGRC 224
                 79**********75389988665.6669****986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       630  (0.0351386); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1368.50
//
Query:       EFC35245.1  [L=312]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.05   13.3   4.4      0.076   12.7   4.4    1.2  1  QWRF      QWRF family
       0.34    9.4   4.1       0.38    9.3   4.1    1.1  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> QWRF  QWRF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   4.4   8.5e-06     0.076      23     113 ..      66     180 ..      46     198 .. 0.45

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 8.5e-06
        QWRF  23 tssrlrrlsdpgsptsss....................skvkskkssldsaplssprsransla........rg.g.saralsPsklss..stsspsrg 89 
                  +++++  +++++ ++s+                    +          + +++++ ++ans +         + + + r+lsPs  ss  s+ s s+ 
  EFC35245.1  66 ENQTTHTITEDNDDNTSNileddidtasegifldnvqsP----------T-TTTTAPQQANSCSdedsvssqHSiAiPIRSLSPSNISSpsSPVSISQL 153
                 455555544444444444454454444333333333221..........2.222222222222222221111111237788888777775545555555 PP

        QWRF  90 lespsrprsssslkvss...assgkgv 113
                  +sp++p s+ s k ss   +ss  + 
  EFC35245.1 154 SSSPTTPNSFLSRKNSSngvKSSNTSN 180
                 666666666666554433332222222 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   4.1   4.2e-05      0.38     233     378 ..      44     178 ..      18     263 .. 0.45

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 4.2e-05
    Macoilin 233 alsknnhslnkkdsslklpeleyrekkksakssrsdskkkhehnesvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssn... 328
                  +s n++   + +++ +l+ ++++++++ +  +++d++ ++  ++++ + ++e  +++n  ++   ++++++++++++  e+sv+s++s + +  +   
  EFC35245.1  44 DVSYNEALEVN-STNDTLSLIHEENQTTHTITEDNDDNTSNILEDDI-DTASEGIFLDNVQSP--TTTTTAPQQANSCSDEDSVSSQHSIAIPIRSlsp 138
                 33333332222.22223333322222222222212221111111111.112222222222222..2222334444444444444444433322211222 PP

    Macoilin 329 knskkasagsagssnssskkhsessksvtsssssknskkqklpaGkssaa 378
                 +n          ss ss+ + s+ s+s+t+ +s  + +k++  + kss++
  EFC35245.1 139 SNI---------SSPSSPVSISQLSSSPTTPNSFLS-RKNSSNGVKSSNT 178
                 232.........333444444444444444442222.2222211111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (312 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       891  (0.049696); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 1884.68
//
Query:       EFC35246.1  [L=384]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-17   64.1  95.5    0.00014   22.2  12.4    6.7  6  EGF_2     EGF-like domain
     0.0072   16.6  66.6       0.12   12.7   6.0    7.0  6  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   7.2   8.7e-05      0.78      11      32 .]       1      21 [.       1      21 [. 0.88
   2 !   17.2   7.9   5.5e-07    0.0049       4      32 .]      33      60 ..      29      60 .. 0.88
   3 !   13.3   7.2     9e-06      0.08       8      32 .]      81     103 ..      75     103 .. 0.90
   4 !   19.8  11.1   8.3e-08   0.00075       3      32 .]     114     142 ..     108     142 .. 0.91
   5 !   22.2  12.4   1.5e-08   0.00014       4      32 .]     153     181 ..     147     181 .. 0.82
   6 !   12.7   9.8   1.4e-05      0.13       6      32 .]     195     220 ..     191     220 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 8.7e-05
       EGF_2 11 hGtCvnqcGqCdCdsgyqGktC 32
                +G C  ++  C+C++gy+G  C
  EFC35246.1  1 GGNCSLPN-TCSCSNGYTGTEC 21
                599*8555.9************ PP

  == domain 2  score: 17.2 bits;  conditional E-value: 5.5e-07
       EGF_2  4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                s++ C+g G C +++ +C C++gy+   C
  EFC35246.1 33 SSNVCSGKGACLSSN-NCTCNAGYFDSEC 60
                4799*******9888.8********9998 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 9e-06
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 Cg +GtCv ++  C+C+ gy G +C
  EFC35246.1  81 CG-NGTCVGPN-LCSCNLGYVGSNC 103
                 76.7****888.9************ PP

  == domain 4  score: 19.8 bits;  conditional E-value: 8.3e-08
       EGF_2   3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++++iC+ +G C+++   C+C++g++G +C
  EFC35246.1 114 NNSNICSSNGLCISPD-ICQCFNGWYGQNC 142
                 3489*********999.************* PP

  == domain 5  score: 22.2 bits;  conditional E-value: 1.5e-08
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +  C+g+G+C n  + C+C++gy+G++C
  EFC35246.1 153 NeSAVCSGRGKCSNY-NLCSCNTGYTGPNC 181
                 35778*******844.47************ PP

  == domain 6  score: 12.7 bits;  conditional E-value: 1.4e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+  G C++ + +C+C+ gy G++C
  EFC35246.1 195 TVCSSFGDCISYN-NCQCKLGYRGNQC 220
                 67*******9555.8************ PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   1.5    0.0012        11      21      30 ..       9      18 ..       2      20 .. 0.93
   2 !    6.8   2.5   0.00097       8.7       3      30 ..      34      57 ..      32      59 .. 0.84
   3 ?    0.9   6.4     0.065   5.8e+02       6      32 .]      81     102 ..      77     102 .. 0.77
   4 !   12.7   6.0   1.3e-05      0.12       4      31 ..     114     140 ..     108     141 .. 0.85
   5 !    8.5   7.6   0.00027       2.4       5      32 .]     154     180 ..     142     180 .. 0.86
   6 !   10.9   3.6     5e-05      0.45       3      31 ..     193     218 ..     190     219 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0012
                EEEECTTEES CS
         EGF 21 tCiCpeGytG 30
                tC C++GytG
  EFC35246.1  9 TCSCSNGYTG 18
                8********9 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.00097
                STTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF  3 pnpCsngGtCvdtgrggytCiCpeGytG 30
                +n Cs+ G C+++     +C+C  Gy+ 
  EFC35246.1 34 SNVCSGKGACLSSN----NCTCNAGYFD 57
                566*******7777....*******975 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.065
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 C ++GtCv +      C C  Gy G++
  EFC35246.1  81 C-GNGTCVGP----NLCSCNLGYVGSN 102
                 6.67899333....37*******9985 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 1.3e-05
                 TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np...CsngGtCvdtgrggytCiCpeGytGk 31 
                 n+   Cs +G C+++     +C+C +G+ G 
  EFC35246.1 114 NNsniCSSNGLCISPD----ICQCFNGWYGQ 140
                 77779***********....********996 PP

  == domain 5  score: 8.5 bits;  conditional E-value: 0.00027
                 T...STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGkr 32 
                     Cs++G+C ++      C C +GytG++
  EFC35246.1 154 EsavCSGRGKCSNYN----LCSCNTGYTGPN 180
                 4556*******7777....8*********86 PP

  == domain 6  score: 10.9 bits;  conditional E-value: 5e-05
                 STT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 +++ Cs  G C+++     +C+C+ Gy G+
  EFC35246.1 193 DTTvCSSFGDCISYN----NCQCKLGYRGN 218
                 4447***********....*********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (384 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       688  (0.0383736); expected 358.6 (0.02)
Passed bias filter:                      185  (0.0103185); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.37s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2101.69
//
Query:       EFC35247.1  [L=244]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.5e-08   33.3   0.1    9.2e-08   32.6   0.1    1.3  1  Ank_2     Ankyrin repeats (3 copies)
    4.7e-05   23.5   0.0      0.034   14.7   0.0    2.9  2  Ank_3     Ankyrin repeat
    0.00015   22.1   0.0       0.36   11.4   0.0    2.5  2  Ank       Ankyrin repeat
    0.00068   20.1   0.0     0.0022   18.5   0.0    1.9  2  Ank_4     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.013   15.8   0.1      0.037   14.4   0.1    1.8  1  Ank_5     Ankyrin repeats (many copies)
      0.045   13.6   0.1       0.08   12.8   0.1    1.3  1  DUF3862   Domain of Unknown Function with PDB structure (DUF3


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.6   0.1   3.1e-11   9.2e-08       4      75 ..      14      96 ..       9     106 .. 0.74

  Alignments for each domain:
  == domain 1  score: 32.6 bits;  conditional E-value: 3.1e-11
       Ank_2  4 AakngnlelvklL.l.egadpnk.ngktaLhyAakng..nleivklLleh.......adndgrtpLhyAarsghleivklLlek 75
                A+k+g+l++++ L l +  + n+ ++ t L +A+ ++  + ei++lLl+         +++ rtpL++A +++++ei+klLl k
  EFC35247.1 14 AIKQGDLSILQSLdLvSVIN-NNyDEATLLSIACGQNkcCPEIIQLLLAVptidlnkNNEEERTPLQIAKSEKNIEIIKLLLGK 96
                45578899999995543333.334789********98556699*****955556443337799******9999********954 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   1.2e-05     0.034       3      30 ..      39      68 ..      37      69 .. 0.89
   2 !    5.8   0.0    0.0088        26       3      24 ..      75      96 ..      73     100 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.2e-05
       Ank_3  3 etpLhlAarsgnl..eivkfLlenkgadvn 30
                 t+L +A+ ++++  ei+++Ll  + +d+n
  EFC35247.1 39 ATLLSIACGQNKCcpEIIQLLLAVPTIDLN 68
                69***********655************99 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0088
       Ank_3  3 etpLhlAarsgnleivkfLlen 24
                +tpL +A +  n+ei+k+Ll +
  EFC35247.1 75 RTPLQIAKSEKNIEIIKLLLGK 96
                8******************985 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.1    0.0012       3.6       3      22 ..      39      60 ..      37      71 .. 0.73
   2 !   11.4   0.0   0.00012      0.36       3      24 ..      75      95 ..      73     104 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0012
                BBHHHHHH.HHTT..HHHHHHHH CS
         Ank  3 nTPLHlAa.tngk..kriiklLL 22
                 T L +A+ + +k  ++ii+lLL
  EFC35247.1 39 ATLLSIACgQ-NKccPEIIQLLL 60
                59999***44.33699******9 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00012
                BBHHHHHHHHTTHHHHHHHHTT CS
         Ank  3 nTPLHlAatngkkriiklLLhG 24
                +TPL +A ++++ +iiklLL G
  EFC35247.1 75 RTPLQIAKSEKNIEIIKLLL-G 95
                7*****9899**********.7 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       4.3   1.3e+04      42      52 ..      14      24 ..      13      26 .. 0.48
   2 !   18.5   0.0   7.5e-07    0.0022       3      55 .]      40      94 ..      38      94 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4.3
       Ank_4 42 Aakrgnveilk 52
                A+k g+++il+
  EFC35247.1 14 AIKQGDLSILQ 24
                44555555544 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 7.5e-07
       Ank_4  3 taLhyaai..sgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55
                t+L  a+   +++ e+++lLl+   +d+n+  n++ +t+l+iA +  n+ei+klLl
  EFC35247.1 40 TLLSIACGqnKCCPEIIQLLLAVpTIDLNKN-NEEERTPLQIAKSEKNIEIIKLLL 94
                67888888899**********8778*****9.***********9999********8 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.1   1.2e-05     0.037       8      56 .]      32      81 ..      23      81 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.2e-05
       Ank_5  8 dvnrldgggntpLhvAak.yg.aadvvrlLl.argadlnltdsrGltaldlA 56
                 +n++d+   t L +A+  +  ++++++lLl  +  dln  +++ +t+l++A
  EFC35247.1 32 INNNYDEA--TLLSIACGqNKcCPEIIQLLLaVPTIDLNKNNEEERTPLQIA 81
                34555555..********6553456666666********************9 PP

>> DUF3862  Domain of Unknown Function with PDB structure (DUF3862)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   2.7e-05      0.08      50      96 ..     105     151 ..      99     161 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.7e-05
                 EEEEEEEETTEEEEEEEETTEEEEEEEES--------B-HHHHHH-- CS
     DUF3862  50 lddytWtkDgvtitvqlyedstvvksisnfkfareaklskkdydslk 96 
                 +d+yt + Dg  i +   +d +++ksis++  +r++  ++++y+ + 
  EFC35247.1 105 IDKYTTSNDGEMILIGSENDPSISKSISEYLKNRSLVYGNDQYNTFS 151
                 89*****************************************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       521  (0.0290591); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1393.04
//
Query:       EFC35248.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0001   22.8   1.7     0.0001   22.8   1.7    2.3  2  Syntaxin-6_N     Syntaxin 6, N-terminal
    0.00011   22.2   2.5     0.0002   21.3   2.5    1.4  1  Apolipoprotein   Apolipoprotein A1/A4/E domain
    0.00011   22.2  11.9    0.00011   22.2  11.9    1.9  2  DUF1664          Protein of unknown function (DUF1664)
    0.00013   21.9   6.0    0.00025   20.9   6.0    1.4  1  Bacillus_HBL     Bacillus haemolytic enterotoxin (HBL)
    0.00018   21.3   3.2     0.0004   20.1   3.2    1.5  1  BCAS2            Breast carcinoma amplified sequence 2 (BCAS2
    0.00054   20.1   9.0     0.0013   18.9   9.0    1.6  1  TssO             Type VI secretion system, TssO
    0.00073   19.1   3.8     0.0015   18.1   3.8    1.5  1  Fzo_mitofusin    fzo-like conserved region
     0.0015   18.0  14.4     0.0015   18.0  14.4    2.2  2  DUF4618          Domain of unknown function (DUF4618)
     0.0015   18.7   1.9     0.0053   17.0   1.9    2.0  1  DUF948           Bacterial protein of unknown function (DUF94
      0.003   17.8   8.8      0.003   17.8   8.8    2.5  2  KxDL             Uncharacterized conserved protein
     0.0053   16.5  11.4      0.035   13.9   3.6    2.8  2  DivIC            Septum formation initiator
     0.0075   16.6   5.0      0.044   14.2   0.6    2.9  2  LPP              Lipoprotein leucine-zipper
     0.0077   16.0   2.6      0.018   14.8   2.6    1.7  1  Lectin_N         Hepatic lectin, N-terminal domain
     0.0078   16.2   4.2      0.084   12.8   2.7    2.4  2  DUF2461          Conserved hypothetical protein (DUF2461)
     0.0085   15.9  14.6     0.0085   15.9  14.6    2.4  2  CdvA             CdvA-like coiled-coil domain
  ------ inclusion threshold ------
      0.011   16.0   7.7      0.029   14.6   7.7    1.7  1  BLOC1_2          Biogenesis of lysosome-related organelles co
      0.011   15.7   0.0      0.019   15.0   0.0    1.4  1  Baculo_PEP_C     Baculovirus polyhedron envelope protein, PEP
      0.012   14.3  17.6      0.015   14.0  17.6    1.1  1  AAA_13           AAA domain
      0.015   15.8   3.2      0.015   15.8   3.2    1.7  1  T3SSipB          Type III cell invasion protein SipB
      0.022   15.3  10.9      0.022   15.3  10.9    2.6  2  HIP1_clath_bdg   Clathrin-binding domain of Huntingtin-intera
      0.023   15.3   4.4       0.13   12.9   4.4    2.2  1  DUF883           Bacterial protein of unknown function (DUF88
      0.025   15.0  17.4    1.2e+02    3.1  16.1    3.6  2  FlaC_arch        Flagella accessory protein C (FlaC)
      0.029   14.3   0.4      0.096   12.6   0.2    1.9  2  ApoO             Apolipoprotein O
       0.03   14.2   6.7       0.03   14.2   6.7    1.9  1  ACCA             Acetyl co-enzyme A carboxylase carboxyltrans
      0.049   13.8   2.9      0.049   13.8   2.9    3.0  2  Fib_alpha        Fibrinogen alpha/beta chain family
      0.062   13.4  11.5      0.032   14.3   9.2    1.8  1  DUF4337          Domain of unknown function (DUF4337)
      0.078   11.6   0.5       0.11   11.2   0.5    1.3  1  Tweety           Tweety
       0.12   12.7   4.9        4.1    7.8   1.5    3.8  5  NAAA-beta        beta subunit of N-acylethanolamine-hydrolyzi
       0.12   11.7   3.8       0.23   10.8   3.8    1.4  1  DUF4407          Domain of unknown function (DUF4407)
       0.12   10.7   6.7       0.19   10.1   6.7    1.2  1  Hemagglutinin    Haemagglutinin
       0.12   12.1   4.9       0.27   11.0   0.6    2.5  2  DASH_Duo1        DASH complex subunit Duo1
       0.15   12.0  12.4       0.06   13.3   7.5    2.6  2  FlxA             FlxA-like protein
       0.25    9.2  12.1      0.041   11.9   8.6    1.4  2  Prominin         Prominin
       0.25   11.4   0.2       0.25   11.4   0.2    2.9  2  TPR_MLP1_2       TPR/MLP1/MLP2-like protein
       0.25   11.3  12.5      0.029   14.4   7.5    2.1  1  Laminin_II       Laminin Domain II
       0.34   10.9  16.5       0.85    9.6  16.5    1.8  1  DUF1640          Protein of unknown function (DUF1640)
       0.44   10.5  11.4       0.11   12.4   7.3    2.1  1  DUF4446          Protein of unknown function (DUF4446)
       0.44   10.7   4.9       0.32   11.1   2.5    1.8  2  Cob_adeno_trans  Cobalamin adenosyltransferase
       0.51    9.2   7.1        0.6    9.0   7.1    1.1  1  LMBR1            LMBR1-like membrane protein
       0.59    9.9  21.5      0.099   12.4   7.8    2.3  2  FAM184           Family with sequence similarity 184, A and B
       0.65    9.7   6.8        1.4    8.7   6.8    1.6  1  EMC3_TMCO1       Integral membrane protein EMC3/TMCO1-like
       0.77    8.9  16.8      0.021   14.1   8.0    2.0  2  TMPIT            TMPIT-like protein
       0.91   10.0  17.8        1.4    9.3  17.8    1.4  1  AAA_23           AAA domain
       0.95    9.9  14.6       0.98    9.8   8.8    3.3  2  V-SNARE          Vesicle transport v-SNARE protein N-terminus
          1    8.9  22.5        1.4    8.4  22.5    1.3  1  DUF4795          Domain of unknown function (DUF4795)
        1.3    9.2  13.2       0.87    9.7   8.4    2.8  2  Vps51            Vps51/Vps67
        1.4    9.5  19.9       0.14   12.7  12.5    2.7  2  YtxH             YtxH-like protein
        1.7    8.3  15.8        1.4    8.6  14.7    1.3  1  AAA_11           AAA domain
        1.8    7.9   6.7        3.4    7.0   5.6    1.9  2  ZnuA             Zinc-uptake complex component A periplasmic
        2.2    8.2   4.3        2.6    7.9   1.2    2.6  3  DASH_Dam1        DASH complex subunit Dam1
        2.3    8.4  12.2      0.063   13.4   5.2    2.0  1  DUF2730          Protein of unknown function (DUF2730)
        2.6    7.9  10.2         11    5.8   0.1    2.1  2  FliP             FliP family
        2.8    8.3   7.4        3.7    7.9   6.9    1.4  1  DUF4199          Protein of unknown function (DUF4199)
        4.3    6.5  17.3       0.17   11.2   8.5    2.1  2  FmiP_Thoc5       Fms-interacting protein/Thoc5
        4.4    7.5  13.0       0.19   11.9   4.3    2.1  2  DAG_kinase_N     Diacylglycerol kinase N-terminus
        5.2    5.9  22.2      0.038   12.9  12.7    1.9  2  Spc7             Spc7 kinetochore protein
        5.5    7.3  18.9       0.39   11.0   7.9    2.2  2  Vfa1             AAA-ATPase Vps4-associated protein 1
        5.7    6.7  22.4      0.041   13.7  10.8    2.3  2  DUF724           Protein of unknown function (DUF724)
        5.7    6.5  12.3        1.5    8.4   9.1    1.7  1  Phage_GPO        Phage capsid scaffolding protein (GPO) serin
        5.7    5.8   9.0        0.6    9.1   4.5    1.6  2  DUF3987          Protein of unknown function (DUF3987)
        5.7    6.4   5.9        1.3    8.4   2.7    1.5  1  Allexi_40kDa     Allexivirus 40kDa protein
        6.2    7.6  13.6       0.21   12.3   5.1    2.4  2  DUF2203          Uncharacterized conserved protein (DUF2203)
        7.5    6.1  14.7        4.1    6.9  12.7    1.7  2  HAUS6_N          HAUS augmin-like complex subunit 6 N-terminu
        7.9    6.4  17.8        1.2    9.1   3.6    2.7  2  Prefoldin        Prefoldin subunit
        7.9    6.7  13.2         42    4.3  11.0    3.2  2  YojJ             Bacterial membrane-spanning protein N-termin
        8.1    6.3  12.0       0.78    9.6   5.9    2.2  2  CK2S             Casein Kinase 2 substrate


Domain annotation for each model (and alignments):
>> Syntaxin-6_N  Syntaxin 6, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.8       8.9   2.4e+03      52      52 ..      61      61 ..      14     107 .. 0.58
   2 !   22.8   1.7   3.8e-07    0.0001      23      81 ..     144     202 ..     128     209 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 8.9
  Syntaxin-6_N 52 s 52
                  +
    EFC35248.1 61 K 61
                  1 PP

  == domain 2  score: 22.8 bits;  conditional E-value: 3.8e-07
  Syntaxin-6_N  23 rwerlledtssstseeldetrteLrkalrsiewdledLeetvriveknpskfkidekel 81 
                   ++++ +++++++ +ee++e++++++k+++++++d++dL++ v+ v+k+ s+ k d +++
    EFC35248.1 144 EMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTV 202
                   332222333344799***************************99999877766555544 PP

>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   2.5   7.4e-07    0.0002      35     101 ..     138     203 ..     128     209 .. 0.87

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 7.4e-07
                     HHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHCCHHCHCCHC CS
  Apolipoprotein  35 leelrarlraeleevrarlepyrdevqeqlgqnleelrqrlapyteelrerlaadaeelqeqlavya 101
                     ++++ +++r+e++   + +++ ++e+++ +++++++++++++ + +e+ + +++d+ e+++ ++++ 
      EFC35248.1 138 QKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEV-KDVKKDVSEIKRDVRTVR 203
                     677889999********************************9999999.66999****999998875 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1       7.7   2.1e+03      88      88 ..      89      89 ..      57     133 .. 0.51
   2 !   22.2  11.9   4.1e-07   0.00011      36     104 ..     139     207 ..     126     212 .] 0.86

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 7.7
     DUF1664 88 e 88
                +
  EFC35248.1 89 N 89
                1 PP

  == domain 2  score: 22.2 bits;  conditional E-value: 4.1e-07
     DUF1664  36 krslsdavesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedve 104
                 k  +++  e++ k++++++e++++ k++++++i+ v k +++ k+  k++k++v+e+++d++++++ + 
  EFC35248.1 139 KNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILM 207
                 455788999999999999999999999999999999999999999999999999999999999887765 PP

>> Bacillus_HBL  Bacillus haemolytic enterotoxin (HBL)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   6.0   9.1e-07   0.00025      83     155 ..     133     208 ..     123     211 .. 0.81

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 9.1e-07
  Bacillus_HBL  83 kFqsyyktlveav...dkkdkaellellekLqeeiqqnqkevkqlikeLkklklklakdsknFktdvdeltsilag 155
                    F+s++k++ +      +k+ +e++e +++L++++ +  k vk++i++Lkk  ++++kd+++ k dv ++ +il +
    EFC35248.1 133 AFSSFQKNMMKEMreeMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILMN 208
                   5777777777777555577778899999999999999999999999999999999999999999999999999865 PP

>> BCAS2  Breast carcinoma amplified sequence 2 (BCAS2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   3.2   1.5e-06    0.0004     114     198 ..     123     208 ..     120     211 .. 0.88

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 1.5e-06
       BCAS2 114 leLlekygknaWrv.hneqleaelkklekeleetkeeieevnrqRkseQeeageeLksleekWrelvsknleieaaceeleaeiee 198
                 l+++ ++ ++a+   +++ ++++ ++++k+++e+kee++e++++ k+e +++++ +++l+++ +++ + + ei++++ ++++ + +
  EFC35248.1 123 LDIMMHFIAQAFSSfQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILMN 208
                 67788888888876146677889999***************************************************999987665 PP

>> TssO  Type VI secretion system, TssO
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   9.0   4.7e-06    0.0013      10      97 ..     116     205 ..     108     211 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 4.7e-06
        TssO  10 flyflllFlvtvlllflivffffkssplqekeil.lkelerkk.kfeekqkelkkkvdsiykkIdsLkpevnavfle.neIkkdlndiknt 97 
                 + +f++++ +++ ++    f +f++  ++e  ++  k++++ k +++e +k++kk+++ ++k+I+ Lk+ev++v    +eIk+d++ ++++
  EFC35248.1 116 IPLFVGSLDIMMHFIA-QAFSSFQKNMMKEMREEmQKNIKEMKeEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDvSEIKRDVRTVRKI 205
                 5567777777777777.4455555566666665557898886515677899****************9999999875489**999999987 PP

>> Fzo_mitofusin  fzo-like conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   3.8   5.6e-06    0.0015      88     139 ..     138     189 ..     123     210 .. 0.81

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 5.6e-06
  Fzo_mitofusin  88 sancshqvqqelsstfarlcqqvdetekeleeeikelekeiekleevqkkak 139
                     +n+ + +++e+++ +++++++ +e +k++++eik+++k+i+ l++  k  k
     EFC35248.1 138 QKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVK 189
                    4688889999*******************************99987655444 PP

>> DUF4618  Domain of unknown function (DUF4618)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6  12.1      0.14        38     186     217 ..     137     168 ..      23     169 .. 0.71
   2 !   18.0  14.4   5.5e-06    0.0015     154     230 ..     130     206 ..     105     209 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.14
     DUF4618 186 lenqvlkkeiekfrefieeleeeipeLkaeve 217
                 ++++ +k+  e+++++i+e++ee++eLk++++
  EFC35248.1 137 FQKNMMKEMREEMQKNIKEMKEEMQELKKDMK 168
                 33334444446778888888888888888876 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 5.5e-06
     DUF4618 154 lskkiqkkkekllkslaektlkatqeaLlqktlenqvlkkeiekfrefieeleeeipeLkaeveqLqaqaeeprevi 230
                 + + +   +++++k++ e+++k+++e+ +++   ++++kkei+ +++ i++l++e+++ k++v +++++++ +r++ 
  EFC35248.1 130 IAQAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKIL 206
                 45556667899999999999999999999999999999999999999999999999999999999999999999975 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   1.9   1.9e-05    0.0053      25      86 ..     143     201 ..     121     206 .. 0.67

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.9e-05
      DUF948  25 kktldeaaatieelekqvdpilkevedllakvnelledvneklekvdplteavadlgesvse 86 
                 k++ +e+++ i+e++++++++ k++++ ++ v++   d+n+  ++v+ + + v ++ + v++
  EFC35248.1 143 KEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKK---DINDLKKEVKDVKKDVSEIKRDVRT 201
                 4555677788888888888888888888877777...6666666666666666666666655 PP

>> KxDL  Uncharacterized conserved protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.3       1.7   4.6e+02      16      42 ..       4      31 ..       1      44 [. 0.78
   2 !   17.8   8.8   1.1e-05     0.003       4      78 ..     132     206 ..     129     209 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 1.7
        KxDL 16 alQaqtsgrl.nkknreLlelnalsqer 42
                ++Q+q s+rl n+k    le  a ++er
  EFC35248.1  4 KKQRQFSKRLfNSKVMDFLEAAAVVEER 31
                7999999995488888888888888877 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 1.1e-05
        KxDL   4 savdsedldeilalQaqtsgrlnkknreLlelnalsqerlaklrarfkqgtkllkevkkdLesifkkirslkakl 78 
                 +a++s + + +  + +++ + +++ ++e++el + ++++ +++++++++ +k +k+vkkd   i++ +r+ ++ l
  EFC35248.1 132 QAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKIL 206
                 666666666777778899999999999999999999999999999999999999999999999999999988766 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   2.1      0.01       2.7       7      48 ..     127     168 ..     125     169 .. 0.85
   2 !   13.9   3.6   0.00013     0.035      28      61 ..     166     199 ..     164     205 .. 0.55

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.01
                 XXXXXXXXXXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
       DivIC   7 lllifgkkgllaykqlkqeiaalqaelaklkaeneeLeaevk 48 
                 +++i  + + ++   +k+ +++ q++++++k+e +eL++  k
  EFC35248.1 127 MHFIAQAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMK 168
                 67777778888899999999*****************99877 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 0.00013
                 HHHHHHHHHHHHHHHHHHHHCC-XXXXXXXXXXX CS
       DivIC  28 alqaelaklkaeneeLeaevkdLksdedyieerA 61 
                 + ++e++ +k+++++L++evkd k+d + i++  
  EFC35248.1 166 DMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDV 199
                 4556666666666666666666666666555433 PP

>> LPP  Lipoprotein leucine-zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.7      0.25        69       5      26 ..     149     170 ..     138     176 .. 0.63
   2 !   14.2   0.6   0.00016     0.044       3      33 ..     172     202 ..     170     204 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.25
         LPP   5 LssqVsqLkskvdqlssdvnsa 26 
                 + ++++++k+++++l++d+++ 
  EFC35248.1 149 MQKNIKEMKEEMQELKKDMKKE 170
                 4455666666666666665554 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 0.00016
         LPP   3 deLssqVsqLkskvdqlssdvnsakaaaqaa 33 
                 + + +++++Lk++v+ +++dv+++k ++ ++
  EFC35248.1 172 KDVKKDINDLKKEVKDVKKDVSEIKRDVRTV 202
                 56779**********************9876 PP

>> Lectin_N  Hepatic lectin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   2.6   6.7e-05     0.018      61     123 ..     131     194 ..     123     208 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 6.7e-05
    Lectin_N  61 ketfsnfssstlaeiqa.lssqggslsekvtsleaklekkqqdlkadhselllhvkqlvkdLrt 123
                  ++fs f ++++ e+++ ++ + ++++e+++ l+  ++k+ +d+k+d  +l   vk ++kd+  
  EFC35248.1 131 AQAFSSFQKNMMKEMREeMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSE 194
                 6789999999999998625556899999999999999999999999999999999999999865 PP

>> DUF2461  Conserved hypothetical protein (DUF2461)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.1     0.018       4.8     104     138 ..     128     162 ..     118     164 .. 0.86
   2 !   12.8   2.7   0.00031     0.084      19      67 ..     154     200 ..     147     205 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.018
     DUF2461 104 sflggGlwapeaatlaklReaidenpeelrailee 138
                  f++  + + ++++++++Re++++n +e+++ ++e
  EFC35248.1 128 HFIAQAFSSFQKNMMKEMREEMQKNIKEMKEEMQE 162
                 57888899999*****************9998865 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 0.00031
     DUF2461  19 kahkaeYerakkpfealveelteelaevdpeipelpakdvvfRiyRDvR 67 
                 k+ k+e +++kk++++ +++++++++++++e+++   k+ v+ i+RDvR
  EFC35248.1 154 KEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDV--KKDVSEIKRDVR 200
                 56788888899999999999999999888888765..899********9 PP

>> CdvA  CdvA-like coiled-coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9  14.6   3.1e-05    0.0085      16      65 ..     138     187 ..     134     191 .. 0.92
   2 ?    7.5   2.5     0.013       3.4      23      65 ..     167     208 ..     167     210 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 3.1e-05
        CdvA  16 pkstyeeikekleealkklkekakelkeklkkrlkeledqikslekalan 65 
                 +k +++e++e++++ +k++ke+++elk+ +kk++k++++ i+ l+k + +
  EFC35248.1 138 QKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKD 187
                 7899****************************************997655 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.013
        CdvA  23 ikekleealkklkekakelkeklkkrlkeledqikslekalan 65 
                 +k+++++  k++++ +ke+k+ +kk ++e++  ++++ k l+n
  EFC35248.1 167 MKKEIKDVKKDINDLKKEVKD-VKKDVSEIKRDVRTVRKILMN 208
                 788888888999998888886.799999999999999999988 PP

>> BLOC1_2  Biogenesis of lysosome-related organelles complex-1 subunit 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   7.7   0.00011     0.029      23      79 ..     140     197 ..     132     206 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 0.00011
     BLOC1_2  23 klLeklNeaasekykklkdvaaslekkle.klnekyeelqpylqqidqiekqvteLee 79 
                 ++++++ e++++++k++k+++++l+k+++ +++  ++ ++ +++++++++k+v+e++ 
  EFC35248.1 140 NMMKEMREEMQKNIKEMKEEMQELKKDMKkEIKDVKKDINDLKKEVKDVKKDVSEIKR 197
                 6677888888888888888888888888624777777888888888888888877765 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.0   6.8e-05     0.019      55     111 ..     139     195 ..     120     208 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 6.8e-05
  Baculo_PEP_C  55 ksllaeldtrldtlltnLtdalnalqdtlrneLtnlnsiltnLlssvtNinstLnnl 111
                   k++++e++++++++++++++ +++l++++++e++ +++++++L  +v  +++ ++ +
    EFC35248.1 139 KNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEI 195
                   345668888999999999999999999999999999999999999888887766655 PP

>> AAA_13  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0  17.6   5.6e-05     0.015     315     469 ..      29     208 ..       3     211 .. 0.62

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 5.6e-05
      AAA_13 315 ensafeedkeelkaeaealeeqLkglqraleaK.rkepfksvelesvkaki.e........sikklvaeineliakhNekvanleeekeeakkklelhl 403
                 e+++ +e+++++++e  + e +Lkgl+r l +K rk++ k ve+ s ++ + e                + +++++  e +++ +  k++ ++++ l++
  EFC35248.1  29 EEREKNEAVHKVQQEPTVEEPRLKGLRRWLLKKgRKKLLKLVETVSESDVSkEnkeksednI-------VVAVVSEEKEGISSAQVIKQDYAEEIPLFV 120
                 3456788899******************9988868899998888776666632223333330.......445566666666666666666666666666 PP

      AAA_13 404 v.........................eeleseldeykkkykklekaieklekelkeeeaelkkleeeikeLekqlrdekpaaeeinkeLka 469
                                           ee++++++e+k+++++l+   ++++ke+k+ +++++ l++e+k+ +k ++++k+ +  + k+L +
  EFC35248.1 121 GsldimmhfiaqafssfqknmmkemrEEMQKNIKEMKEEMQELK---KDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILMN 208
                 56666666666666555543332222444444433333333333...55666666666777777777777777777777776666666655 PP

>> T3SSipB  Type III cell invasion protein SipB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.8   3.2   5.4e-05     0.015      32      94 ..     133     196 ..     125     205 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 5.4e-05
                 HHHHHTTTTT----STHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHHHHHHHHTT-- CS
     T3SSipB  32 amskaqqeaasklSdelqtalseakgatddleaai.ekadqaksaadaatkkvdeaqkrlkeLa 94 
                 a s  q+++ +++ +e+q+ ++e+k+  ++l++ + ++++++k+++++++k v++++k ++e++
  EFC35248.1 133 AFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMkKEIKDVKKDINDLKKEVKDVKKDVSEIK 196
                 5556677888888888888888887766666655514578999999999999999999999984 PP

>> HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interacting protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   3.4       8.2   2.2e+03      49      77 ..      32      60 ..       2     102 .. 0.58
   2 ?   15.3  10.9   8.2e-05     0.022      15      77 ..     139     201 ..     135     208 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 8.2
  HIP1_clath_bdg 49 eqkeelekLkreleakraelarlkssLes 77
                    e++e + k+++e + ++ +l+ l+  L +
      EFC35248.1 32 EKNEAVHKVQQEPTVEEPRLKGLRRWLLK 60
                    44455555555544444444444443332 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 8.2e-05
  HIP1_clath_bdg  15 lsvarqaqeeverekkeleeelerlkeeaerkleeqkeelekLkreleakraelarlkssLes 77 
                       ++++ +ee++++ ke++ee+++lk++ ++++++ k+ ++ Lk+e+++ +++++++k  +++
      EFC35248.1 139 KNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRT 201
                     67889999***********************************************99987776 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   4.4   0.00047      0.13       9      62 ..     140     193 ..     129     204 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 0.00047
      DUF883   9 slladleellkeaadeageeaeelRerleerlerarerlrdaeeavaerakeaa 62 
                 +++++++e +++  +e +ee++el++ ++++++++++ ++d++++v++  k+++
  EFC35248.1 140 NMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVS 193
                 556666666667777777788888888888888888888888877777666665 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0      0.46   1.2e+02      38      50 ..      64      77 ..      31      80 .. 0.87
   2 ?    3.1  16.1      0.45   1.2e+02       4      40 ..     166     202 ..     132     209 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.46
   FlaC_arch 38 kdllsLYEvVsn.q 50
                k+ll+L E+Vs+ +
  EFC35248.1 64 KKLLKLVETVSEsD 77
                89********9855 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.45
   FlaC_arch   4 elEnklsklsteletvkkeneelsksveelkenVkdl 40 
                 ++ +++++++  ++ +kke ++++k+v e+k++V+ +
  EFC35248.1 166 DMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTV 202
                 4556666666677777777777777777777777544 PP

>> ApoO  Apolipoprotein O
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.2   0.00035     0.096      20      63 ..     142     185 ..     135     195 .. 0.89
   2 ?   -1.2   0.0       6.7   1.8e+03      12      30 ..     191     209 ..     184     211 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00035
        ApoO  20 vrslRkslepytsavqdelnkvkskvetaeqsvtdtiasLkepp 63 
                 ++++R++++++++++++e++++k+ ++++ + v++ i+ Lk++ 
  EFC35248.1 142 MKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEV 185
                 6889************************************9875 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 6.7
        ApoO  12 ptdrLeegvrslRkslepy 30 
                 +++++++ vr++Rk l +y
  EFC35248.1 191 DVSEIKRDVRTVRKILMNY 209
                 5677888999999988776 PP

>> ACCA  Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   6.7   0.00011      0.03       3      49 ..     148     194 ..     146     208 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 0.00011
        ACCA   3 dfekpiaeleekieelkklaeesevdlseeieklekkleklkkeiyk 49 
                 +++k+i+e++e+++elkk  +++  d++++i++l+k+++++kk++ +
  EFC35248.1 148 EMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSE 194
                 7899************************************9998764 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   9.2         3   8.2e+02      25     125 ..     141     167 ..      40     171 .. 0.74
   2 ?   13.8   2.9   0.00018     0.049      22      66 ..     163     207 ..     162     211 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 3
                 CCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  25 lllkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesneqkiqkLeq 123
                 ++++++++                                                                          +q+++++ ++++q+L++
  EFC35248.1 141 MMKEMREE--------------------------------------------------------------------------MQKNIKEMKEEMQELKK 165
                 33333333..........................................................................44455555555555554 PP

                 HH CS
   Fib_alpha 124 di 125
                 d+
  EFC35248.1 166 DM 167
                 44 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 0.00018
                 HHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH CS
   Fib_alpha  22 lqdlllkyekdvkkdlekleneleeisnstkeaeelvkeikdslr 66 
                 l++ ++k  kdvkkd+++l++e++++++  +e+++ v++++++l 
  EFC35248.1 163 LKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILM 207
                 788999******************************999998875 PP

>> DUF4337  Domain of unknown function (DUF4337)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   9.2   0.00012     0.032      37     108 ..     131     200 ..      89     206 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 0.00012
     DUF4337  37 sdqWafYQAksikehlaeleleqlelllkakaeelaaavdkkiakykkkiarykkekkeikkkAkeleaerd 108
                 + +++ +Q + +ke   e++++  e++++   +el+++++k+i+++kk+i+  kke k++kk+  e+++++ 
  EFC35248.1 131 AQAFSSFQKNMMKEMREEMQKNIKEMKEE--MQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVR 200
                 56788999999999999998888888654..68899999999999999999999999999999999988776 PP

>> Tweety  Tweety
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.5    0.0004      0.11     265     333 ..     124     194 ..     108     211 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.0004
      Tweety 265 dilqyylkC..sqsltnpFqqrLtesqkaltemqeqveellriavelfptaekkLlaiqellnsternlhq 333
                 di+ ++++   s  ++n  +   +e+qk ++em+e+++el++   ++ +  +k+++ +++ ++  +  + +
  EFC35248.1 124 DIMMHFIAQafSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSE 194
                 56666654311344566677777788999999999999999999999999998888888877766655554 PP

>> NAAA-beta  beta subunit of N-acylethanolamine-hydrolyzing acid amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0       3.7     1e+03      38      57 ..       8      27 ..       5      31 .. 0.81
   2 ?    2.0   0.0      0.99   2.7e+02      23      53 ..     110     139 ..     105     149 .. 0.70
   3 ?    1.4   0.1       1.5     4e+02      20      40 ..     140     160 ..     130     163 .. 0.81
   4 ?    7.8   1.5     0.015       4.1      22      50 ..     153     179 ..     149     189 .. 0.72
   5 ?    6.7   0.7     0.033         9      21      43 ..     163     185 ..     161     204 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 3.7
   NAAA-beta 38 dllkslvpgklvdlvdklaa 57
                ++ k l++ k++d+++++a 
  EFC35248.1  8 QFSKRLFNSKVMDFLEAAAV 27
                566788899******99875 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.99
   NAAA-beta  23 kdykpelksliqvlkdllkslvpgklvdlvd 53 
                 +dy++e+  +++ l+ ++  ++ + + ++ +
  EFC35248.1 110 QDYAEEIPLFVGSLDIMMH-FIAQAFSSFQK 139
                 7899999999999988886.55556665555 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 1.5
   NAAA-beta  20 qvakdykpelksliqvlkdll 40 
                 +++k++++e+++ i+ +k+ +
  EFC35248.1 140 NMMKEMREEMQKNIKEMKEEM 160
                 678889999988888888765 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.015
   NAAA-beta  22 akdykpelksliqvlkdllkslvpgklvd 50 
                 +k++k+e+++l++++k+ +k++  +k ++
  EFC35248.1 153 IKEMKEEMQELKKDMKKEIKDV--KKDIN 179
                 6888999999999999999865..44443 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.033
   NAAA-beta  21 vakdykpelksliqvlkdllksl 43 
                 + kd+k+e+k+++++++dl k++
  EFC35248.1 163 LKKDMKKEIKDVKKDINDLKKEV 185
                 669**************987765 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   3.8   0.00084      0.23     104     162 ..     137     198 ..     126     204 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00084
     DUF4407 104 FekeIdaelaeeqqeeakelkeqlaaa...ltaelaeleaqiaalqaeidaaearldalrae 162
                 F+k   +e++ee q+++ke ke++++    +++e+++ +++i++l++e++  ++++++ +++
  EFC35248.1 137 FQKNMMKEMREEMQKNIKEMKEEMQELkkdMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRD 198
                 66666677777777777777666665566688888888888888888888888877766555 PP

>> Hemagglutinin  Haemagglutinin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   6.7    0.0007      0.19     367     423 ..     147     203 ..     137     209 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.0007
                    HHHHHHHHHHHHHHHHHHHHTTTEEEBXSSXXTTTTHHHHHHHHHHHHHHHHHHHHH CS
  Hemagglutinin 367 kstqeainkitkkvnsliekenkqleavgkelnelekrieeldkkvddgfldvityn 423
                    +  q+ i+++ +++  l + ++k+++ v k++n+l+k++++++k v + + dv t +
     EFC35248.1 147 EEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVR 203
                    6789************************************************98875 PP

>> DASH_Duo1  DASH complex subunit Duo1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.6      0.28        75      14      38 ..     144     168 ..     136     170 .. 0.75
   2 ?   11.0   0.6   0.00099      0.27       7      50 ..     169     212 .]     162     212 .] 0.89

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.28
   DASH_Duo1  14 evienviesLkkaksniervketve 38 
                 e+ e +++++k++k++++++k+ ++
  EFC35248.1 144 EMREEMQKNIKEMKEEMQELKKDMK 168
                 5667888888888888888877655 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00099
   DASH_Duo1   7 eqLrkinevienviesLkkaksniervketvestntLLdkWirI 50 
                 ++++++ + i++++++ k++k++++++k+ v ++ ++L ++ +I
  EFC35248.1 169 KEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILMNYRKI 212
                 468899999*******************************9988 PP

>> FlxA  FlxA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.2       4.2   1.1e+03      26      53 ..      63      89 ..      58      93 .. 0.65
   2 ?   13.3   7.5   0.00022      0.06       5      70 ..     132     197 ..     130     204 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 4.2
        FlxA 26 iknlqkqLkelsesdeltkeekkkqqql 53
                 k+l k ++ +ses + +ke+k+k ++ 
  EFC35248.1 63 RKKLLKLVETVSES-DVSKENKEKSEDN 89
                56666666777777.7777777766655 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 0.00022
        FlxA   5 sasssssssgsasqiasLqkQiknlqkqLkelsesdeltkeekkkqqqliqaQIqqlqaQIaqlqq 70 
                 +a+ss +++ +++  +++qk ik+++++++el+++ ++  ++ kk ++ ++++++++++ +  +++
  EFC35248.1 132 QAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKR 197
                 7888888999999999*******************88888889999999***99999998887776 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       2.1   5.7e+02     630     705 ..      25      98 ..       6     116 .. 0.63
   2 ?   11.9   8.6   0.00015     0.041     333     703 ..     136     201 ..      94     212 .] 0.44

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.1
    Prominin 630 aekleelanelsngkknlkqslkneaqdlraiqqelvlplessvkklkksvkkldeensdlqesikkllaaverae 705
                 a+ +ee  ++   +  +++q+ + e   l+ + + l ++ ++++ kl ++v + d ++++ ++s ++++ av + e
  EFC35248.1  25 AAVVEEREKNEAVH--KVQQEPTVEEPRLKGLRRWLLKKGRKKLLKLVETVSESDVSKENKEKSEDNIVVAVVSEE 98 
                 44444444444333..677777777777777777777777777777777777777766666666666666555544 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00015
    Prominin 333 tnlssivkeglarlneipekvknqtaevvpdlkkalakgreqikklakkiprealdavisdlenterssktfddvvekyekyrwliglivcsllllivv 431
                 +  ++++ke                                                                                          
  EFC35248.1 136 SFQKNMMKE------------------------------------------------------------------------------------------ 144
                 222222222.......................................................................................... PP

    Prominin 432 ililgLlcGilGlsrtatptdrgcskntGasfLlvgvglsFlffsllmlvvlltFlvGlnvyklvCeplesneLfrvlDtpgllpeldLsrllskklkk 530
                                                                                                                    
  EFC35248.1   - ---------------------------------------------------------------------------------------------------   -
                 ................................................................................................... PP

    Prominin 531 nltisevikaCkanesifkvLrlnnlydieellnikklteeiqkelenlkvdlsnlelLteeerkdLeklresglskihsslyleqlckkltkvnletl 629
                                                                                                                    
  EFC35248.1   - ---------------------------------------------------------------------------------------------------   -
                 ................................................................................................... PP

    Prominin 630 aekleelanelsngkknlkqslkneaqdlraiqqelvlplessvkklkksvkkldeensdlqesikkllaaver 703
                                  ++++++++ +++++  qel + +++++k++kk +++l++e +d ++ ++++ + v+ 
  EFC35248.1 145 -----------------MREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRT 201
                 .................333333333333333333333333333333333333333333333333333333333 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  15.1     0.019       5.2      74     117 ..     140     183 ..      67     197 .. 0.62
   2 ?   11.4   0.2   0.00093      0.25       1      39 [.     169     207 ..     169     211 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.019
  TPR_MLP1_2  74 aelkaeaesakaeleeseesweeqkeelekelselekriedlne 117
                 + +k+ +e+ +++++e +e+++e k+ ++ke+++++k i+dl++
  EFC35248.1 140 NMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKK 183
                 44566666666666666666666677777777777776666665 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00093
  TPR_MLP1_2   1 kelksleeeikslkeekeeaeaklqklqedlekqaeiak 39 
                 ke+k ++++i++lk+e ++ +++++++++d+++ ++i+ 
  EFC35248.1 169 KEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILM 207
                 588999999999999999999999999999999988875 PP

>> Laminin_II  Laminin Domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   7.5   0.00011     0.029      17      78 ..     144     202 ..     129     212 .] 0.74

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 0.00011
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHH CS
  Laminin_II  17 eqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkel 78 
                 e  +++++n++++ke+++e++++   +++++kd +k i+d +++vk+++k + ++   ++++
  EFC35248.1 144 EMREEMQKNIKEMKEEMQELKKD---MKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTV 202
                 56688999999999999999888...677777777777777777777777777766555555 PP

>> DUF1640  Protein of unknown function (DUF1640)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6  16.5    0.0031      0.85      49     124 ..     124     192 ..      64     205 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.0031
     DUF1640  49 ekseylqkaalselrkevqisersefaalrseteklqreleklkqkLreeidklkadirldlnleKgrireelakl 124
                 ++++  +  a+s+++k++ +  r+e   ++++ +++++e+++lk+++++ei+++k+d    +n+ K+++++  +  
  EFC35248.1 124 DIMMHFIAQAFSSFQKNMMKEMREE---MQKNIKEMKEEMQELKKDMKKEIKDVKKD----INDLKKEVKDVKKDV 192
                 5555556667777777776666655...45688888889999999999999888888....888888888866654 PP

>> DUF4446  Protein of unknown function (DUF4446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   7.3   0.00041      0.11      20      82 ..     130     192 ..     118     208 .. 0.41

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00041
     DUF4446  20 llvklkklkkkykklmkgkdgksleellkekleeveelkeeseelekeieeleeklkkslqkv 82 
                 +   +++++k++ k m+++ +k+++e+ +e  e  +++k+e ++++k+i++l++++k   + v
  EFC35248.1 130 IAQAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDV 192
                 333333344444444443333333333333333333333333334444444444333333322 PP

>> Cob_adeno_trans  Cobalamin adenosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       5.4   1.5e+03      57      69 ..      59      71 ..      16     110 .. 0.57
   2 ?   11.1   2.5    0.0012      0.32      28     106 ..     119     196 ..     104     208 .. 0.64

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 5.4
                     HHHHHHHHHHHHH CS
  Cob_adeno_trans 57 LeeiqneLfdlga 69
                     L++  ++L++l +
       EFC35248.1 59 LKKGRKKLLKLVE 71
                     2333334444444 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.0012
                      HHHHHHHHHHHHHHHHHHCTTT.....THHHHHHHHHHHHHHHHHHHHHHT.-BTCCG-S--HHHHHHHHHHHHHHHHHS--EE CS
  Cob_adeno_trans  28 ayGtvDelnsaiglarallaee.....eeelkeaLeeiqneLfdlgaelatpekkkekkkiteeeveelekeideleaelpplk 106
                      ++G++D +  +i  a +  +++     +ee+++ ++e+++e+ +l +++     kke k+++++ +++l ke+++++++++++k
       EFC35248.1 119 FVGSLDIMMHFIAQAFSSFQKNmmkemREEMQKNIKEMKEEMQELKKDM-----KKEIKDVKKD-INDLKKEVKDVKKDVSEIK 196
                      6788888888888888777655544444455555555555555555555.....3344445555.7777777777776666555 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   7.1    0.0022       0.6     220     312 ..      35     193 ..       9     210 .. 0.48

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0022
       LMBR1 220 e............................reledllkevkklrksisesd................................plrkyleeilk...... 252
                 e                            ++l +l++ v++++ s+++++                                p                
  EFC35248.1  35 EavhkvqqeptveeprlkglrrwllkkgrKKLLKLVETVSESDVSKENKEksednivvavvseekegissaqvikqdyaeeiP---------Lfvgsld 124
                 44455555555555555555555555555555555555555555554444222223333333333333333333333333330.........2444444 PP

       LMBR1 253 ...............kvPeeiaeklksnenkteeslaklekqlikalqkrertekqwkrllekalelediiknks 312
                                ++ +e++e++++n ++ +e++++l+k+++k++++ ++  + +k+ ++ +       k+ s
  EFC35248.1 125 immhfiaqafssfqkNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDV------KKDVS 193
                 4444444444444445555555555555666666666666666666666666666666655555......22222 PP

>> FAM184  Family with sequence similarity 184, A and B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   5.8      0.24        64     109     182 ..      11      86 ..       4     115 .. 0.73
   2 ?   12.4   7.8   0.00037     0.099     145     195 ..     142     192 ..     128     208 .. 0.54

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.24
      FAM184 109 krkFeeklrqfaqlqeqle.qekekaLeelrkkhreeveeLlkeqeaqsekllkeqekl.eekhkaeveklkeeve 182
                 kr F+ k+ +f ++++ +e +ek++a+ +++++ + e  +L+  ++   +k  k   kl e   + +v k ++e  
  EFC35248.1  11 KRLFNSKVMDFLEAAAVVEeREKNEAVHKVQQEPTVEEPRLKGLRRWLLKKGRKKLLKLvETVSESDVSKENKEKS 86 
                 899********9999888769***********99999999988888877777777777734444566666665544 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 0.00037
      FAM184 145 veeLlkeqeaqsekllkeqekleekhkaeveklkeeveelekekkklveey 195
                 ++e+++e +++ +++++e ++l++ +k+e++++k+++++l+ke k + ++ 
  EFC35248.1 142 MKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDV 192
                 344555555555555555555555555555555555555555555554443 PP

>> EMC3_TMCO1  Integral membrane protein EMC3/TMCO1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   6.8     0.005       1.4      25      87 ..     125     185 ..     112     208 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.005
  EMC3_TMCO1  25 iltgllsellqkllidkkkmekeqkrekelqkrarelqkngdklklkklekrqeelmedqsem 87 
                 i+ +++++  +++   k+ m+++++ +++  k+++e +++ +k ++k++++ ++++++ ++e+
  EFC35248.1 125 IMMHFIAQAFSSFQ--KNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEV 185
                 67788888888887..88888888888888888888888888888888888888887776665 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   1.5       1.2   3.4e+02      54     110 ..      23      82 ..       2     101 .. 0.68
   2 ?   14.1   8.0   7.7e-05     0.021      12      68 ..     143     199 ..     128     212 .] 0.59

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 1.2
       TMPIT  54 kklkksvkeeeeeeveelkeelkerkkvlkevesllpkk.nglylklvlG..nvnvslln 110
                 +      ++e++e+v+++++e   ++  lk +   l kk +   lklv +  + +vs  n
  EFC35248.1  23 EAAAVVEEREKNEAVHKVQQEPTVEEPRLKGLRRWLLKKgRKKLLKLVETvsESDVSKEN 82 
                 333333457889999999999999999999999999999888888887442244444433 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 7.7e-05
       TMPIT  12 kel.eetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeev 68 
                 ke+ ee +k++k+  ee+++l+++++keik  kk++++lk+++k++kk+v+e + + v
  EFC35248.1 143 KEMrEEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIK-RDV 199
                 333133446666677777777777777777777777777777777777765322.222 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3  17.8    0.0053       1.4      93     197 ..      72     190 ..       2     197 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0053
      AAA_23  93 erelsk..kkgkttkkaklellei..deleqfisellgskki..........ilnlilflgqerfeefelkdkkerleelekeleeledekkllekl.. 175
                 + ++s+  k++k++++++        +e ++ is+   +k++          +l++   + ++ f  f+++  ke  ee++k ++e ++e ++l+k   
  EFC35248.1  72 TVSESDvsKENKEKSEDNIVV--AvvSEEKEGISSAQVIKQDyaeeiplfvgSLDIMMHFIAQAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDmk 168
                 222222002222333333333..2447777888875555555446666666555555555556688899999999999999999999999999998765 PP

      AAA_23 176 eqekekekeleeleeeleeilk 197
                 +++k+ +k +++l++e ++++k
  EFC35248.1 169 KEIKDVKKDINDLKKEVKDVKK 190
                 5556666666666666666555 PP

>> V-SNARE  Vesicle transport v-SNARE protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1         7   1.9e+03      21      33 ..      31      43 ..      22      44 .. 0.78
   2 ?    9.8   8.8    0.0036      0.98      35      79 .]     147     187 ..     138     187 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 7
     V-SNARE 21 eerkaalreiekk 33
                 e+++a+++++++
  EFC35248.1 31 REKNEAVHKVQQE 43
                3899999999985 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.0036
     V-SNARE  35 deaeelldqMelEvrnlpsserasykaklreykselkklkkelkr 79 
                 +e+++ +++M  E ++l    ++ +k+ +++ k++++ lkke+k+
  EFC35248.1 147 EEMQKNIKEMKEEMQEL----KKDMKKEIKDVKKDINDLKKEVKD 187
                 57777777777777766....79*******************985 PP

>> DUF4795  Domain of unknown function (DUF4795)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4  22.5    0.0053       1.4      59     146 ..      73     193 ..      11     211 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0053
     DUF4795  59 adkeeveeelaekadkeaLatkvsrdq..............................fDeakkeLek.mleellekleeqeealkkaldtLqeelkekl 126
                    ++v++e +ek+  + + ++vs+++                              + +a++ ++k m++e++e ++++ +++k+ +++L++++k+ +
  EFC35248.1  73 VSESDVSKENKEKSEDNIVVAVVSEEKegissaqvikqdyaeeiplfvgsldimmhfIAQAFSSFQKnMMKEMREEMQKNIKEMKEEMQELKKDMKKEI 171
                 33468899999999999999999999999999999***************6666555445555554313477777777777777777777777777777 PP

     DUF4795 127 d..rlelepLkeqleerlkelq 146
                    ++++++Lk+++++  k ++
  EFC35248.1 172 KdvKKDINDLKKEVKDVKKDVS 193
                 7777777777777774433333 PP

>> Vps51  Vps51/Vps67
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.2       1.8   4.8e+02      10      62 ..      26      75 ..       9      90 .. 0.79
   2 ?    9.7   8.4    0.0032      0.87      23      84 ..     141     202 ..     126     204 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 1.8
       Vps51 10 ayvrellakstlkellkveasllseiraldselkalVydnYskLisasdtIrk 62
                a v+   ++++ + ++kv+++ + e+ +l+  ++ l  +  +kL++  +t+++
  EFC35248.1 26 AVVE---EREKNEAVHKVQQEPTVEEPRLKGLRRWLLKKGRKKLLKLVETVSE 75
                5555...3666677888888888888888888888888888888888888875 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0032
       Vps51  23 ellkveasllseiraldselkalVydnYskLisasdtIrkmksemdkldqklselkqaiski 84 
                  +++++++++++i+++++e+++l  d  ++  ++ ++I+++k+e++++++ +se+k  ++ +
  EFC35248.1 141 MMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTV 202
                 5678999************************************************9988766 PP

>> YtxH  YtxH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   6.2       1.8   4.9e+02      52      74 ..     132     160 ..      16     162 .. 0.72
   2 ?   12.7  12.5   0.00051      0.14      24      70 ..     143     192 ..     139     201 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 1.8
        YtxH  52 a......kekaedlkekvkekadelkekv 74 
                        k+  ++++e++++ ++e+ke++
  EFC35248.1 132 QafssfqKNMMKEMREEMQKNIKEMKEEM 160
                 04445554444444444444444444433 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 0.00051
        YtxH  24 ketRkdlkekaddlkekakelleeakeka...kekaedlkekvkekadel 70 
                 ke+R++++++ +++ke ++el++++k+     k+ ++dlk++vk+  +++
  EFC35248.1 143 KEMREEMQKNIKEMKEEMQELKKDMKKEIkdvKKDINDLKKEVKDVKKDV 192
                 89***********************7777555555666666655555554 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  14.7    0.0052       1.4      77     186 ..      56     204 ..      41     209 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0052
      AAA_11  77 glldsegekykpkivRvgneeeriseavksvsleekvekrlekee......................................kaqlakeiskelekla 137
                 + l ++g+k+ +k+v  ++e+ ++s+++k+ s +++v +  ++e+                                      + +++ke+++e +k+ 
  EFC35248.1  56 RWLLKKGRKKLLKLVETVSES-DVSKENKEKSEDNIVVAVVSEEKegissaqvikqdyaeeiplfvgsldimmhfiaqafssfQKNMMKEMREEMQKNI 153
                 45567999999*******999.89999999999999999998888999*********************999999999999998888999999999999 PP

      AAA_11 138 kelrafeeeeek..eklkkskekskskleqerrklkkerkelskeleeaee 186
                 ke++++ +e +k  +k+ k  +k+ ++l++e +++kk ++e++++++++++
  EFC35248.1 154 KEMKEEMQELKKdmKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRK 204
                 999777777665444445555555566666666666666666666666554 PP

>> ZnuA  Zinc-uptake complex component A periplasmic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.2         4   1.1e+03     190     221 ..      69     101 ..      26     117 .. 0.59
   2 ?    7.0   5.6     0.013       3.4     105     152 ..     126     177 ..      70     182 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 4
                 HHHHHHHTT-SEEEEETTS-THHHHHHHHHH.T CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.x RF
        ZnuA 190 lieeikeagvkaifveplaspklaetlaeea.g 221
                 l+e+++e++v     e+++++ +++ + ee  g
  EFC35248.1  69 LVETVSESDVSKENKEKSEDNIVVAVVSEEKeG 101
                 444444444444333334444444444443333 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.013
                 HHHHHHHHHHH....HTGGGHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSGT CS
                 xxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ZnuA 105 mveniadaLve....adpanadtyeanaaayiekLeeldaeireelaeipee 152
                 m++ ia+a+++    +  +  ++ ++n ++++e+++el++++++e+++++++
  EFC35248.1 126 MMHFIAQAFSSfqknMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKD 177
                 66667777777222235677889************************99975 PP

>> DASH_Dam1  DASH complex subunit Dam1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1       4.6   1.3e+03       8      20 ..     130     142 ..     126     150 .. 0.65
   2 ?    7.9   1.2    0.0096       2.6       2      32 ..     150     181 ..     147     185 .. 0.85
   3 ?    1.9   0.1       0.7   1.9e+02       3      21 ..     176     194 ..     167     200 .. 0.58

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 4.6
   DASH_Dam1   8 LaDsletLdknle 20 
                 +a + + ++kn++
  EFC35248.1 130 IAQAFSSFQKNMM 142
                 5566667777765 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0096
   DASH_Dam1   2 epafaeLaDsletLdknle.dLqqihesLsdf 32 
                 +++++e+++++++L+k ++ ++++++++++d+
  EFC35248.1 150 QKNIKEMKEEMQELKKDMKkEIKDVKKDINDL 181
                 6889*************973699999999875 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.7
   DASH_Dam1   3 pafaeLaDsletLdknled 21 
                 + +++L++++++++k +++
  EFC35248.1 176 KDINDLKKEVKDVKKDVSE 194
                 3455555555555555555 PP

>> DUF2730  Protein of unknown function (DUF2730)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   5.2   0.00023     0.063      32      91 ..     143     204 ..     118     207 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 0.00023
     DUF2730  32 redleklaekveendkrlteletkven..LPtakdlekLkllladlrgelkaleaevrqlsh 91 
                 +e  e+++++++e+++ ++el+  +++     +kd+++Lk++++d++ ++++++++vr++++
  EFC35248.1 143 KEMREEMQKNIKEMKEEMQELKKDMKKeiKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRK 204
                 33334455556666666666665443311345777788888888888888888777777765 PP

>> FliP  FliP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.1     0.042        11      69     121 ..      34      90 ..      18     108 .. 0.65
   2 ?    4.4   6.0      0.11        31      52     102 ..     127     179 ..      99     207 .. 0.64

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.042
                 XXXXXX-HHHH.HHHHHHHHHHHHHHHHHHHHHHHHHHHCTT-...-SSGGGS-HHH CS
        FliP  69 plleeeiteee.alekakeplrefllkqtrekdlalflelaek...eeeeeevplsv 121
                 + + +++++e  + e   + lr++llk+ r+k l+l+ +++e+   +e++e+++  +
  EFC35248.1  34 NEAVHKVQQEPtVEEPRLKGLRRWLLKKGRKKLLKLVETVSESdvsKENKEKSEDNI 90 
                 33333555555144557899*******************999876523333322222 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.11
                 XXXXXXXXXXXXXXXXXXXXXXX-HHHHHHHHHHHHHHHHHHHHHH..HHHHH CS
        FliP  52 lfvmaPvleeineeavkplleeeiteeealekakeplrefllkqtr..ekdla 102
                 ++ +a  +++ +++++k++ ee  ++ + +++++++l+++++k+ +  +kd++
  EFC35248.1 127 MHFIAQAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKdvKKDIN 179
                 22334455666666666666666666668999999999999997763333333 PP

>> DUF4199  Protein of unknown function (DUF4199)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   6.9     0.014       3.7      85     133 ..     125     176 ..     116     196 .. 0.54

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.014
     DUF4199  85 avfqyiyfnfi..dpdfienyiaeilekleeakeesae.eenaemseeeike 133
                 +++++i  +f   ++++++++ +e++++++e+kee++e ++ ++++ +  k+
  EFC35248.1 125 IMMHFIAQAFSsfQKNMMKEMREEMQKNIKEMKEEMQElKKDMKKEIKDVKK 176
                 4444444333222555566666666666555555555544444444444444 PP

>> FmiP_Thoc5  Fms-interacting protein/Thoc5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   1.5      0.84   2.3e+02     184     231 ..       6      74 ..       1     138 [. 0.56
   2 ?   11.2   8.5   0.00061      0.17     102     153 ..     144     199 ..     136     209 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.84
  FmiP_Thoc5 184 ykeavdkkleveIeGdveeakafnkssnsaeekkaeaessdsdsesq.....................e 231
                 ++++++  ++ ++++ +e a  ++++ ++++ +k ++e   +++  +                     +
  EFC35248.1   6 QRQFSKRLFNSKVMDFLEAAAVVEEREKNEAVHKVQQEPTVEEPRLKglrrwllkkgrkkllklvetvS 74 
                 455555668888888888888888555544444333333333333335444444433333333333221 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00061
  FmiP_Thoc5 102 eqRkelaeqlke....leekkkkleqeieekkkfLssLppkLkslkkatkplqeal 153
                 e R+e+++++ke    ++e kk +++ei+  kk ++ L++++k++kk ++++++++
  EFC35248.1 144 EMREEMQKNIKEmkeeMQELKKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDV 199
                 4566666666551111566788889999999****************999998765 PP

>> DAG_kinase_N  Diacylglycerol kinase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   1.3       1.6   4.4e+02      93     126 ..      37      82 ..       3     118 .. 0.36
   2 ?   11.9   4.3    0.0007      0.19      61     130 ..     122     191 ..     116     209 .. 0.55

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 1.6
  DAG_kinase_N  93 s.........................ksssseenvlkkseesllkskkkkkekkekkkk 126
                                             +             ++llk  ++ +e++ +k++
    EFC35248.1  37 VhkvqqeptveeprlkglrrwllkkgR-------------KKLLKLVETVSESDVSKEN 82 
                   122333333333333333333322220.............2222222222222111111 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.0007
  DAG_kinase_N  61 v.dlpeelcqrLFlsFqkkesqeespesqkkeasksssseenvlkkseesllkskkkkkekkekkkksekk 130
                     d+  ++ ++ F sFqk+  +e+++e+qk+ ++ + ++ ++ +k +++++++ kk  +  k++ k+++k 
    EFC35248.1 122 SlDIMMHFIAQAFSSFQKNMMKEMREEMQKNIKEMK-EEMQELKKDMKKEIKDVKKDINDLKKEVKDVKKD 191
                   5599999***************99977776666322.2222222333333333333333222222222222 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   2.3       5.8   1.6e+03     200     242 ..      58      98 ..      22     117 .. 0.50
   2 ?   12.9  12.7   0.00014     0.038     162     254 ..     139     203 ..     129     212 .] 0.37

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 5.8
        Spc7 200 eLeelreelaelkaeieekkkelaelqeqleeleekieelkeq 242
                  L++ r++l +l ++++  + ++++ ++++ e +  ++ ++e+
  EFC35248.1  58 LLKKGRKKLLKLVETVS--ESDVSKENKEKSEDNIVVAVVSEE 98 
                 34444444444444444..333333333433333333333333 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 0.00014
        Spc7 162 eeeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeae 254
                 ++ ++e+ +e++++ +e++ee+++l++                         +++   ke++++++++++l+++++++k+  se++ +++  +
  EFC35248.1 139 KNMMKEMREEMQKNIKEMKEEMQELKK-------------------------DMK---KEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVR 203
                 233333333333333333333333333.........................333...33333333333333333333333333333333333 PP

>> Vfa1  AAA-ATPase Vps4-associated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   3.2      0.75     2e+02      51     114 ..      16      87 ..       5     118 .. 0.49
   2 ?   11.0   7.9    0.0015      0.39      57     110 ..     138     191 ..     124     209 .. 0.54

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.75
        Vfa1  51 tpivdeeeeeaakkkkeleeeiekvkkeyeekqkkkkekekkk......kekd.......kkdkdkkkekekdkkke 114
                 ++++d  e++a  +++e++e ++kv++e + ++ + k   +++      k  +          ++++ +ke+++k+e
  EFC35248.1  16 SKVMDFLEAAAVVEEREKNEAVHKVQQEPTVEEPRLKG-LRRWllkkgrK--KllklvetV--SESDVSKENKEKSE 87 
                 45555555556667777888888888888888877773.34454544330..133332221..11111111111111 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.0015
        Vfa1  57 eeeeaakkkkeleeeiekvkkeyeekqkkkkekekkkkekd.kkdkdkkkekekd 110
                 +++  ++ ++e++++i+++k+e++e +k  k++ k+  +kd ++ k++ k+ +kd
  EFC35248.1 138 QKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDV-KKDiNDLKKEVKDVKKD 191
                 2333445566699999999999998888777555544.34432222222222222 PP

>> DUF724  Protein of unknown function (DUF724)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   3.6       6.2   1.7e+03     134     163 ..      64      93 ..      14     114 .. 0.61
   2 ?   13.7  10.8   0.00015     0.041     124     185 ..     138     196 ..     129     203 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 6.2
      DUF724 134 elekkilelerqlallkekkeaadkeiarl 163
                 ++  k +e   ++++ ke+ke+++ +i+  
  EFC35248.1  64 KKLLKLVETVSESDVSKENKEKSEDNIVVA 93 
                 333344555566667777777777776544 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 0.00015
      DUF724 124 ekrkleeeidelekkilelerqlallkekkeaadkeiarlkseaekleeeledveqeFeava 185
                 +k+ ++e  +e++k+i+e++++ + lk   ++++kei+++k++ ++l++e++dv++++++++
  EFC35248.1 138 QKNMMKEMREEMQKNIKEMKEEMQELK---KDMKKEIKDVKKDINDLKKEVKDVKKDVSEIK 196
                 456678888899999999999887555...56678888888888888888888888877764 PP

>> Phage_GPO  Phage capsid scaffolding protein (GPO) serine peptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   9.1    0.0056       1.5     180     248 ..     129     199 ..      83     210 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0056
   Phage_GPO 180 rikallskkkksd.darfadveeavelvAeevkelsekveall.aleaelaalkkeveklkaeleaLkekL 248
                  i + +s+ +k+  ++   ++++ ++++ ee++el++++++   + ++++++lkkev++ k++++++k+ +
  EFC35248.1 129 FIAQAFSSFQKNMmKEMREEMQKNIKEMKEEMQELKKDMKKEIkDVKKDINDLKKEVKDVKKDVSEIKRDV 199
                 45666666666652444567888888888888888888887665778888888888888888888888765 PP

>> DUF3987  Protein of unknown function (DUF3987)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       6.7   1.8e+03      95     121 ..      24      51 ..       7      78 .. 0.58
   2 ?    9.1   4.5    0.0022       0.6      62     111 ..     140     185 ..     125     202 .. 0.49

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 6.7
     DUF3987  95 kaakakeakaeealaeleaee.peePkl 121
                 +aa  +e++++ea  ++++e   eeP+l
  EFC35248.1  24 AAAVVEEREKNEAVHKVQQEPtVEEPRL 51 
                 3333334444444444444433344433 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0022
     DUF3987  62 eieaelreeyeeelkeyeaekkaweaelealekkaakakeakaeealael 111
                  + +e+ree+++++ke ++e++++++ +++  k+++k++    ++ ++e+
  EFC35248.1 140 NMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDI----NDLKKEV 185
                 333444555555555555555555554444444444443....2222222 PP

>> Allexi_40kDa  Allexivirus 40kDa protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   2.7    0.0049       1.3      70     137 ..     136     202 ..     119     210 .. 0.54

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0049
  Allexi_40kDa  70 pvsllsqttlLselrdalrtltklldklksvekklelsaetasdskllkklesietsleelhakldel 137
                   +++   ++ +  e++++++++++++++lk+++kk  ++ +++  ++l k+++ +++++ e+++ ++++
    EFC35248.1 136 SFQKNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDI-NDLKKEVKDVKKDVSEIKRDVRTV 202
                   3323333333444445555566666666665555555544443.345677777777777777776655 PP

>> DUF2203  Uncharacterized conserved protein (DUF2203)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   1.3         5   1.4e+03      26      37 ..      63      74 ..      12     120 .. 0.57
   2 ?   12.3   5.1   0.00079      0.21      18      86 ..     141     209 ..     126     211 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 5
     DUF2203 26 rkeleeleeele 37
                rk+l +l+e ++
  EFC35248.1 63 RKKLLKLVETVS 74
                233333333222 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 0.00079
     DUF2203  18 lleelr.alrkeleeleeeleeakaeaekseaaeleaeleeleaeieelveeieelGvevkdleaglvDF 86 
                 +++e+r +++k+++e++ee++e k++++ +e +  +++++ l++e++++ + ++e++ +v+ ++++l+++
  EFC35248.1 141 MMKEMReEMQKNIKEMKEEMQELKKDMK-KEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKILMNY 209
                 4444443456667777777777777754.45889999999999999999999999999999998888766 PP

>> HAUS6_N  HAUS augmin-like complex subunit 6 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.5         4   1.1e+03      72      72 ..      63      63 ..       4     110 .. 0.55
   2 ?    6.9  12.7     0.015       4.1     161     225 ..     132     189 ..      58     206 .. 0.50

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 4
     HAUS6_N 72 R 72
                R
  EFC35248.1 63 R 63
                0 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.015
     HAUS6_N 161 rekaaadrarqkyqenaqllekkerelraeleelqaelkaekeaakkekkeasedaeeekikkvr 225
                 +++++     ++++e  ++++k+++e+++e++el++++k+     ++++ +++++ +++++k+v+
  EFC35248.1 132 QAFSSF--QKNMMKEMREEMQKNIKEMKEEMQELKKDMKK-----EIKDVKKDINDLKKEVKDVK 189
                 222222..25555555555555555555555555555552.....22223333333333333332 PP

>> Prefoldin  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   6.1     0.072        20      82     108 ..     142     168 ..     131     173 .. 0.59
   2 ?    9.1   3.6    0.0044       1.2      72     113 ..     164     205 ..     163     209 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.072
                 HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  82 lkkkleelekqlekleeeleklkdqit 108
                  k+  ee++k++++++ee ++lk+ ++
  EFC35248.1 142 MKEMREEMQKNIKEMKEEMQELKKDMK 168
                 344455555555555555555555554 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0044
                 EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  72 eksleeAiellkkkleelekqlekleeeleklkdqittlean 113
                 +k++++ i+ +kk +++l+k ++++++++ ++k+ + t++++
  EFC35248.1 164 KKDMKKEIKDVKKDINDLKKEVKDVKKDVSEIKRDVRTVRKI 205
                 577888889999999999999999999999999999998776 PP

>> YojJ  Bacterial membrane-spanning protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3  11.0      0.16        42       4      55 ..     139     190 ..     131     194 .. 0.81
   2 ?    3.4   0.4       0.3        83      13      30 ..     180     197 ..     172     209 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.16
        YojJ   4 kcleeelkeklkeeLeqiekeleevlkaldeedeClLcelesirekfaelet 55 
                 k+  +e++e++++++++ ++e++e  k +++e + +  ++++++++++++++
  EFC35248.1 139 KNMMKEMREEMQKNIKEMKEEMQELKKDMKKEIKDVKKDINDLKKEVKDVKK 190
                 5566788899999999999999999999999888888888888888888775 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.3
        YojJ  13 klkeeLeqiekeleevlk 30 
                 +lk+e ++++k+++e+ +
  EFC35248.1 180 DLKKEVKDVKKDVSEIKR 197
                 567777777777777654 PP

>> CK2S  Casein Kinase 2 substrate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.3       3.4   9.1e+02      59      89 ..      53      83 ..      13     111 .. 0.53
   2 ?    9.6   5.9    0.0029      0.78      51     105 ..     132     187 ..     127     199 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 3.4
        CK2S 59 rLrekqlealeevlakLrekleelqkvrdsl 89
                 Lr+ +l++  + l kL e+++e +  ++  
  EFC35248.1 53 GLRRWLLKKGRKKLLKLVETVSESDVSKENK 83
                3566666666667777777777655444444 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0029
        CK2S  51 rdfpdlqerLrekqlealeevlakLrekleelqk.vrdsleklvrdalqlyeekad 105
                 ++f+ +q++++++ +e++++ +++++e+++el+k ++++++  ++d ++l++e +d
  EFC35248.1 132 QAFSSFQKNMMKEMREEMQKNIKEMKEEMQELKKdMKKEIKDVKKDINDLKKEVKD 187
                 68999***************************754999**********99998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5181  (0.288973); expected 358.6 (0.02)
Passed bias filter:                     1492  (0.0832171); expected 358.6 (0.02)
Passed Vit filter:                       380  (0.0211947); expected 17.9 (0.001)
Passed Fwd filter:                       104  (0.00580066); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              66  [number of targets reported over threshold]
# CPU time: 1.22u 0.39s 00:00:01.61 Elapsed: 00:00:00.64
# Mc/sec: 1005.76
//
Query:       EFC35249.1  [L=164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.4e-40  135.2  13.8    4.1e-11   43.2   0.1    5.1  5  Sel1            Sel1 repeat
    0.00043   20.5   0.4       0.76   10.1   0.0    3.4  3  Transpos_assoc  Transposase-associated domain
  ------ inclusion threshold ------
       0.02   15.1   5.4        1.3    9.3   0.2    3.3  3  ANAPC3          Anaphase-promoting complex, cyclosome, subuni
      0.023   15.3   4.4         67    4.4   0.1    4.3  4  TPR_6           Tetratricopeptide repeat
      0.034   14.2   0.5         17    5.7   0.0    3.3  3  TPR_7           Tetratricopeptide repeat
      0.048   13.1   2.7       0.87    9.0   0.4    2.4  2  SNAP            Soluble NSF attachment protein, SNAP
      0.057   13.5  11.6        2.6    8.4   0.1    4.7  5  TPR_2           Tetratricopeptide repeat
       0.11   12.3  10.2        6.9    6.7   0.0    4.7  5  TPR_1           Tetratricopeptide repeat
       0.36   11.7   4.4        5.1    8.0   1.3    2.9  3  Chorion_2       Chorion family 2
        2.7    8.4  22.3        4.7    7.7   0.3    5.8  5  TPR_8           Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.2    0.0015       2.7      29      38 .]       3      12 ..       1      12 [. 0.92
   2 !   40.2   0.1   1.9e-13   3.4e-10       2      38 .]      14      48 ..      13      48 .. 0.93
   3 !   27.6   0.1   1.8e-09   3.2e-06       1      38 []      49      84 ..      49      84 .. 0.91
   4 !   43.2   0.1   2.3e-14   4.1e-11       2      38 .]      86     120 ..      85     120 .. 0.94
   5 !   22.6   0.2     7e-08   0.00013       3      38 .]     123     156 ..     123     156 .. 0.97

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0015
        Sel1 29 wyekAAeqGd 38
                wy kAAe+G+
  EFC35249.1  3 WYLKAAENGH 12
                *********9 PP

  == domain 2  score: 40.2 bits;  conditional E-value: 1.9e-13
        Sel1  2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                 +++  G  +ly+nG+g  kD++kA+ew+ kAAe+G+
  EFC35249.1 14 ISQFEIG--CLYQNGQGATKDYSKAMEWFLKAAENGH 48
                69*****..777************************9 PP

  == domain 3  score: 27.6 bits;  conditional E-value: 1.8e-09
        Sel1  1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                ++++++ G  +ly +G+gv++D++kA+e++  + ++G+
  EFC35249.1 49 SASYHNIG--CLYGYGQGVKQDYSKAMEYFLISTNNGH 84
                57999***..777*****************99999987 PP

  == domain 4  score: 43.2 bits;  conditional E-value: 2.3e-14
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  +++  G   ly+nG+gv++D++kA+ew+ kAAe+G+
  EFC35249.1  86 ISQFEIG--FLYQNGQGVKQDYKKAMEWFLKAAEHGH 120
                 689****..777************************9 PP

  == domain 5  score: 22.6 bits;  conditional E-value: 7e-08
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 A+++ G   lyl G+gv  D+ kA+ew  kAAe+G+
  EFC35249.1 123 AQFQIG--WLYLIGKGVQHDYCKAMEWIIKAAENGS 156
                 9*****..**************************96 PP

>> Transpos_assoc  Transposase-associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   0.00042      0.76       7      58 ..      26      78 ..      21      85 .. 0.82
   2 ?    4.1   0.0     0.033        60       7      33 ..      98     125 ..      93     128 .. 0.80
   3 ?    2.8   0.0     0.081   1.4e+02       3      33 ..     129     161 ..     128     164 .] 0.80

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00042
  Transpos_assoc  7 kkrfskeyiegveeFlefaes.rlskeeeilCpckkCknkkslsreeveeHLl 58
                    ++  +k+y + +e Fl++ae+ ++++ ++i C +   +  k+  ++  e+ L+
      EFC35249.1 26 GQGATKDYSKAMEWFLKAAENgHSASYHNIGCLYGYGQGVKQDYSKAMEYFLI 78
                    677899***************88*********988777777766666666665 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.033
  Transpos_assoc   7 kkrfskeyiegveeFlefaes.rlskee 33 
                     ++  +++y++ +e Fl++ae+ +++++ 
      EFC35249.1  98 GQGVKQDYKKAMEWFLKAAEHgHSCAQF 125
                     567789*************996676665 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.081
  Transpos_assoc   3 Wmy.kkkrfskeyiegveeFlefaes.rlskee 33 
                     W+y  +k  +++y + +e  +++ae+  +++++
      EFC35249.1 129 WLYlIGKGVQHDYCKAMEWIIKAAENgSSAAQN 161
                     99978888999***********99994465555 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.2   0.00073       1.3      32      61 ..      21      53 ..       4      64 .. 0.74
   2 ?    5.9   0.2    0.0084        15      35      58 ..      96     122 ..      92     134 .. 0.72
   3 ?    0.5   0.0       0.4   7.2e+02      37      56 ..     139     158 ..     137     163 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00073
                HHHHTT-.....HHHHHHHHHCTSHHHC-HHHHHH CS
      ANAPC3 32 clylngq.....ykrAyellrkaklnskslgcryl 61
                cly+ngq     y +A+e++ ka +n++s    y 
  EFC35249.1 21 CLYQNGQgatkdYSKAMEWFLKAAENGHSA--SYH 53
                899998888888***********5555555..333 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0084
                 HTT-.....HHHHHHHHHCTSHHHC-HHH CS
      ANAPC3  35 lngq.....ykrAyellrkaklnskslgc 58 
                 +ngq     yk+A+e++ ka  +++ + c
  EFC35249.1  96 QNGQgvkqdYKKAMEWFLKA--AEHGHSC 122
                 555555555***********..4444444 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.4
                 T-HHHHHHHHHCTSHHHC-H CS
      ANAPC3  37 gqykrAyellrkaklnsksl 56 
                  +y +A+e++ ka +n++s 
  EFC35249.1 139 HDYCKAMEWIIKAAENGSSA 158
                 68999****99997777665 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.1     0.038        67       3      21 ..      16      38 ..      15      46 .. 0.82
   2 ?    3.5   0.0     0.075   1.3e+02       5      23 ..      54      76 ..      50      77 .. 0.71
   3 ?    4.2   0.1     0.046        82       3      21 ..      88     110 ..      87     116 .. 0.74
   4 ?    1.8   0.0      0.25   4.5e+02       2      11 ..     123     132 ..     123     146 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.038
                HHHHHHHHHH.H...HHHHHHHH CS
       TPR_6  3 lyklalsyrk.l...gdtdkAle 21
                ++ ++ +y++ +   +d++kA+e
  EFC35249.1 16 QFEIGCLYQNgQgatKDYSKAME 38
                7999*****95599889999987 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.075
                HHHHHHHHH....HHHHHHHHHH CS
       TPR_6  5 klalsyrkl....gdtdkAleal 23
                +++ +y  +    +d++kA+e++
  EFC35249.1 54 NIGCLYGYGqgvkQDYSKAMEYF 76
                56666666336766*******98 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.046
                 HHHHHHHHHH.H...HHHHHHHH CS
       TPR_6   3 lyklalsyrk.l...gdtdkAle 21 
                 ++ ++ +y++ +   +d+ kA+e
  EFC35249.1  88 QFEIGFLYQNgQgvkQDYKKAME 110
                 799*******6666556666665 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.25
                 HHHHHHHHHH CS
       TPR_6   2 Alyklalsyr 11 
                 A+++++++y+
  EFC35249.1 123 AQFQIGWLYL 132
                 89******96 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.16   2.8e+02       8      27 ..      22      43 ..      17      49 .. 0.71
   2 ?    5.7   0.0    0.0095        17       1      22 [.      51      76 ..      51      79 .. 0.89
   3 ?    2.9   0.0     0.078   1.4e+02      13      25 ..     103     115 ..      94     121 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.16
       TPR_7  8 lysr....lGdyeeAielyeqsLa 27
                ly++      dy++A e + +  a
  EFC35249.1 22 LYQNgqgaTKDYSKAMEWFLK--A 43
                55555555669*****99998..4 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0095
       TPR_7  1 aLlnLarlysr....lGdyeeAiely 22
                +++n++ ly       +dy++A e++
  EFC35249.1 51 SYHNIGCLYGYgqgvKQDYSKAMEYF 76
                6899999999999999*********8 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.078
       TPR_7  13 GdyeeAielyeqs 25 
                 +dy++A e + ++
  EFC35249.1 103 QDYKKAMEWFLKA 115
                 8*******99984 PP

>> SNAP  Soluble NSF attachment protein, SNAP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.4   0.00048      0.87     117     178 ..      16      76 ..       6      91 .. 0.74
   2 ?    4.9   0.5    0.0084        15     116     143 ..      87     117 ..      66     126 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00048
                 HHHHHHHHHHTT--HHHHHHHHHHHHHHHHH..TT.-HHHHHHHHHHHHHHHHHTT-HHHHHHHH CS
        SNAP 117 kkeiaelyekelgdlekAieaYekAaelyeq..ee.akalankcllkvAelsaelekyekAieiy 178
                 ++ei+ ly++     + A++ Y kA e++ +  e+  +a+ +++ + +   +  +++y+kA+e +
  EFC35249.1  16 QFEIGCLYQNG----QGATKDYSKAMEWFLKaaENgHSASYHNIGCLYGYGQGVKQDYSKAMEYF 76 
                 56777777777....78888888888888541144477777777777778888889999999988 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0084
                 HHHHHHHHHHHTT...--HHHHHHHHHHHHH CS
        SNAP 116 lkkeiaelyekel...gdlekAieaYekAae 143
                  ++ei+ ly++     +d++kA+e + kAae
  EFC35249.1  87 SQFEIGFLYQNGQgvkQDYKKAMEWFLKAAE 117
                 4778888998876666789999999999987 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       7.3   1.3e+04       7      12 ..      19      24 ..      16      27 .. 0.54
   2 ?    7.4   0.1     0.003       5.4      14      29 ..      30      45 ..      28      46 .. 0.90
   3 ?    2.5   0.4      0.11     2e+02      14      24 ..      66      76 ..      50      78 .. 0.85
   4 ?    8.4   0.1    0.0014       2.6      15      29 ..     103     117 ..     101     119 .. 0.90
   5 ?   -2.8   0.1       5.6     1e+04       4      12 ..     124     132 ..     123     133 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 7.3
       TPR_2  7 lGlayy 12
                +G++y 
  EFC35249.1 19 IGCLYQ 24
                555554 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.003
       TPR_2 14 lgdyeeAleafekAle 29
                 +dy +A e+f kA e
  EFC35249.1 30 TKDYSKAMEWFLKAAE 45
                68************86 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.11
       TPR_2 14 lgdyeeAleaf 24
                ++dy +A e+f
  EFC35249.1 66 KQDYSKAMEYF 76
                57999999999 PP

  == domain 4  score: 8.4 bits;  conditional E-value: 0.0014
       TPR_2  15 gdyeeAleafekAle 29 
                 +dy++A e+f kA e
  EFC35249.1 103 QDYKKAMEWFLKAAE 117
                 79***********87 PP

  == domain 5  score: -2.8 bits;  conditional E-value: 5.6
       TPR_2   4 lynlGlayy 12 
                  +++G++y+
  EFC35249.1 124 QFQIGWLYL 132
                 688999996 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.1    0.0083        15      15      29 ..      31      45 ..      27      46 .. 0.87
   2 ?   -0.0   0.4       0.5   8.9e+02       3      11 ..      51      59 ..      49      61 .. 0.84
   3 ?    2.9   0.0     0.062   1.1e+02      15      24 ..      67      76 ..      64      77 .. 0.86
   4 ?    6.7   0.0    0.0039       6.9      15      29 ..     103     117 ..     100     122 .. 0.87
   5 ?   -3.6   0.0       6.6   1.2e+04       4      12 ..     124     132 ..     123     132 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0083
                T-HHHHHHHHHHHHH CS
       TPR_1 15 gkydeAleyyekALe 29
                ++y +A e + kA e
  EFC35249.1 31 KDYSKAMEWFLKAAE 45
                89*********9965 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.5
                HHHHHHHHH CS
       TPR_1  3 alynlGnay 11
                ++ n+G +y
  EFC35249.1 51 SYHNIGCLY 59
                799****99 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.062
                T-HHHHHHHH CS
       TPR_1 15 gkydeAleyy 24
                ++y +A ey+
  EFC35249.1 67 QDYSKAMEYF 76
                6999999998 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0039
                 T-HHHHHHHHHHHHH CS
       TPR_1  15 gkydeAleyyekALe 29 
                 ++y++A e + kA e
  EFC35249.1 103 QDYKKAMEWFLKAAE 117
                 79***********87 PP

  == domain 5  score: -3.6 bits;  conditional E-value: 6.6
                 HHHHHHHHH CS
       TPR_1   4 lynlGnayf 12 
                  +++G +y+
  EFC35249.1 124 QFQIGWLYL 132
                 578999995 PP

>> Chorion_2  Chorion family 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1      0.08   1.4e+02      23      46 ..      19      51 ..       5      57 .. 0.69
   2 ?    2.9   0.8      0.11   1.9e+02      23      44 ..      55      85 ..      47      90 .. 0.70
   3 ?    8.0   1.3    0.0028       5.1       1      46 [.      60     121 ..      60     161 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.08
   Chorion_2 23 i...ygrgrG.nrgYgrsve.....sgrrygds 46
                i   y++g+G  + Y + +e        ++++s
  EFC35249.1 19 IgclYQNGQGaTKDYSKAMEwflkaAENGHSAS 51
                25559999**99999999998886644444444 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.11
   Chorion_2 23 i...ygrgrG.nrgYgrsve.....sgrryg 44
                i   yg g+G ++ Y + +e      + +++
  EFC35249.1 55 IgclYGYGQGvKQDYSKAMEyflisTNNGHS 85
                2445999999999999998888866444444 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0028
   Chorion_2   1 gYGsapvggyayqvqpaltvkai............ygrgrG.nrgYgrsve...sgrrygds 46 
                 gYG++  + y   ++ +l+  +             y++g+G ++ Y + +e   +  ++g+s
  EFC35249.1  60 GYGQGVKQDYSKAMEYFLISTNNghsisqfeigflYQNGQGvKQDYKKAMEwflKAAEHGHS 121
                 899999999999999999888778899*********************99988844444443 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.3    0.0026       4.7      14      29 ..      30      45 ..      15      46 .. 0.85
   2 ?    2.9   2.7     0.088   1.6e+02       3      24 ..      51      76 ..      49      77 .. 0.64
   3 ?    7.3   0.4    0.0035       6.3      14      28 ..     102     116 ..     102     117 .. 0.89
   4 ?   -0.7   0.1       1.3   2.3e+03       4      12 ..     124     132 ..     123     136 .. 0.78
   5 ?   -2.4   0.1       4.5     8e+03      19      27 ..     143     151 ..     140     153 .. 0.63

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0026
                TT-HHHHHHHHHHHHH CS
       TPR_8 14 lgdyeeAkeyyekale 29
                ++dy +A+e++ ka e
  EFC35249.1 30 TKDYSKAMEWFLKAAE 45
                79***********976 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.088
                HHHHHHHHHHH....TT-HHHHHHHH CS
       TPR_8  3 ayynlgsiylk....lgdyeeAkeyy 24
                +y+n+g++y      ++dy +A+ey+
  EFC35249.1 51 SYHNIGCLYGYgqgvKQDYSKAMEYF 76
                78999999843333345777777776 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0035
                 TT-HHHHHHHHHHHH CS
       TPR_8  14 lgdyeeAkeyyekal 28 
                 ++dy++A+e++ ka 
  EFC35249.1 102 KQDYKKAMEWFLKAA 116
                 579**********96 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 1.3
                 HHHHHHHHH CS
       TPR_8   4 yynlgsiyl 12 
                  +++g++yl
  EFC35249.1 124 QFQIGWLYL 132
                 6899**995 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 4.5
                 HHHHHHHHH CS
       TPR_8  19 eAkeyyeka 27 
                 +A+e++ ka
  EFC35249.1 143 KAMEWIIKA 151
                 677777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       508  (0.028334); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.55
# Mc/sec: 898.17
//
Query:       EFC35250.1  [L=191]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.8e-19   68.5   3.8    1.4e-18   67.8   3.8    1.3  1  Peptidase_C1    Papain family cysteine protease
    0.00024   20.9   0.0    0.00047   20.0   0.0    1.5  1  Propeptide_C1   Peptidase family C1 propeptide
  ------ inclusion threshold ------
      0.057   12.2   0.2      0.075   11.8   0.2    1.2  1  Peptidase_C1_2  Peptidase C1-like family
      0.097   13.1   0.0       0.17   12.3   0.0    1.4  1  Ycf70           Uncharacterized Ycf70-like


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.8   3.8     3e-22   1.4e-18       2      67 ..     125     191 .]     124     191 .] 0.95

  Alignments for each domain:
  == domain 1  score: 67.8 bits;  conditional E-value: 3e-22
                   TSCEETTTTTTG.SG---B-TSSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGG CS
  Peptidase_C1   2 pesvDwrekgga.vtpvkdqgsCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCn 67 
                   p+++D+re+  + ++++k+q++CGsCWafsa ++l dr++ik++ k +v+lS q +v+Cs+ +n+gCn
    EFC35250.1 125 PTQFDAREQWPQcIRSIKNQKNCGSCWAFSASSVLADRFCIKSGgKVNVDLSPQFMVSCSG-QNNGCN 191
                   99******76666*******************************999*************9.8****8 PP

>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.0     1e-07   0.00047       4      37 ..      52      88 ..      50      91 .. 0.94

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1e-07
                   HHHHHHHHC.T-SEEE---..-SSBSHHHHHCCS-B- CS
  Propeptide_C1  4 efIdyiNsk.nttWkAgrN..FdnttlsyikgLlGvl 37
                   e+I +iNs+  ++W+A  +  F++ +l++   LlG+l
     EFC35250.1 52 EMISNINSQpSASWQAVEYpqFKGKSLADMTNLLGAL 88
                   9**********************77**********98 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   1.7e-05     0.075      57      81 ..     140     164 ..     120     181 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.7e-05
                     S--B--BSSTHHHHHHHHHHHHHHH CS
  Peptidase_C1_2  57 evtnqkqsGRCWlFaalnvlRlkll 81 
                     ++ nqk+ G CW F+a  vl  ++ 
      EFC35250.1 140 SIKNQKNCGSCWAFSASSVLADRFC 164
                     688*************999877665 PP

>> Ycf70  Uncharacterized Ycf70-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   3.7e-05      0.17      29      59 ..       9      43 ..       2      67 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.7e-05
       Ycf70 29 ellvmvsglyalfcvflvl....fiffdsfkqesn 59
                 llvmv  l +++c fl+l      ++d f+q+s 
  EFC35250.1  9 TLLVMVGYLIVFLCSFLLLsnsiTCMYDDFQQNSW 43
                69***************9833324689****9984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 1062.10
//
Query:       EFC35251.1  [L=374]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00039   18.8  24.1    0.00048   18.6  24.1    1.1  1  CDC45           CDC45-like protein
  ------ inclusion threshold ------
        0.4    9.1  32.7        0.6    8.5  32.7    1.2  1  Borrelia_P83    Borrelia P83/100 protein
       0.81    8.5   8.8       0.98    8.2   8.8    1.1  1  LMBR1           LMBR1-like membrane protein
        1.6    7.6  22.5        2.2    7.1  22.5    1.1  1  DUF5427         Family of unknown function (DUF5427)
        6.3    6.8   8.6         10    6.1   8.6    1.4  1  Neur_chan_memb  Neurotransmitter-gated ion-channel transmembr
          8    6.2  26.4         15    5.3  26.4    1.4  1  RR_TM4-6        Ryanodine Receptor TM 4-6


Domain annotation for each model (and alignments):
>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6  24.1   1.6e-07   0.00048      98     223 ..     176     297 ..     119     305 .. 0.57

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 1.6e-07
       CDC45  98 seekerivvfDDgdieeeleeere..ayealeeeeesdeedeeeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdeeee....sddddersrk 190
                 s+++ +i+ + D++ +e+ ++e e  + e + ++++ d++ +eeee+  ++e++++ee  +++++ee+++++++krk+    ee+    ++++++ +++
  EFC35251.1 176 SQKNIGIFQWYDENNDEKENDETEinDNEDVGYMNDIDDRCDEEEESRLEEERKKKEE--EKRKQEEKKRNEEEKRKK----EEAikiaKEEKRRIEEE 268
                 3566677777666644444444333366777777777632212221111111111111..111222222222222222....22223333333333333 PP

       CDC45 191 rrrsepsakklrrqlkkerrkyeavlekyysqg 223
                 r+r++      +++++++r++ e++ +kyy++ 
  EFC35251.1 269 RKRKQ----DENQESRRKREEIENKKRKYYEEK 297
                 33333....335558888888899999999875 PP

>> Borrelia_P83  Borrelia P83/100 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  32.7    0.0002       0.6     240     347 ..     188     300 ..     179     314 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0002
  Borrelia_P83 240 ednadkqrkevreklqe.aknlpepadvsskkedkkva.eekkreiekaqkeikkkdeeakkakdak...aedlkkeskaeekeaedkeleakkere 331
                   e+n +k+ +e++ + +e    +++  d  +++e+ +++ e kk+e ek ++e kk++ee k+ k+++   a++ k+   +e k+ +d ++e++++re
    EFC35251.1 188 ENNDEKENDETEINDNEdVGYMNDIDDRCDEEEESRLEeERKKKEEEKRKQEEKKRNEEEKRKKEEAikiAKEEKRRIEEERKRKQDENQESRRKRE 284
                   4556666666666666523345555666677788888735678899999999999999988888886555666666677888899************ PP

  Borrelia_P83 332 evaeDlqkikeevkak 347
                   e+ +  +k  ee++ +
    EFC35251.1 285 EIENKKRKYYEEKQDN 300
                   ****999999888754 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   8.8   0.00033      0.98     192     332 ..      90     307 ..      51     325 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00033
       LMBR1 192 r....................eiksdldeelkklyfeaaklntekeeae.................................................r 221
                                      +++++++e lk ++++++ l+++k+e                                                   +
  EFC35251.1  90 GtlcvrtgidflaissttcdtKYSKEIKEFLKDYSIHIKDLTKTKNEIIisgskmlstgvslgekywlldpktspkrflmtlgnngsqknigifqwydE 188
                 055555555555555666667889999999999999999999888777799999999999999999999999999999999999999999999855543 PP

       LMBR1 222 eledllkevkklrksisesdplrkyleeilkkvPeeiaeklks.............nenkteeslaklekqlikalqkrertekqwkrllekaleledi 307
                      ++e ++ +++i++++    y+++i + + ee +++l++             +++ +ee+  k e++++ a ++++r+e++ kr  ++  e    
  EFC35251.1 189 ----NNDEKENDETEINDNE-DVGYMNDIDDRCDEEEESRLEEerkkkeeekrkqeEKKRNEEEKRKKEEAIKIAKEEKRRIEEERKRKQDENQESRRK 282
                 ....3334444444555555.6699***********999999998888888877654444666666666777777888888888888877777555544 PP

       LMBR1 308 iknksskekefkssessrrgefakq 332
                  ++ ++k+++ +++++ ++ +++k+
  EFC35251.1 283 REEIENKKRKYYEEKQDNEPPMKKK 307
                 5555555555555544555555554 PP

>> DUF5427  Family of unknown function (DUF5427)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  22.5   0.00074       2.2      17     131 ..     188     302 ..     166     318 .. 0.44

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00074
     DUF5427  17 kkkkktkkkkkakkkdee.diLaeLe.eLakke.srpaTPrvksnkskkaspkkkksaeepakeekkkeeessedkrksvestrsleasetpseeesee 112
                 ++++++++++++ +++e+   +++++    ++e sr +  r k++++ k+++++kk++ee++ ++++  + ++e+kr+ +e+ ++ ++++++s  ++ee
  EFC35251.1 188 ENNDEKENDETEINDNEDvGYMNDIDdRCDEEEeSRLEEERKKKEEE-KRKQEEKKRNEEEKRKKEEAIKIAKEEKRRIEEERKRKQDENQESRRKREE 285
                 33333333333333333346788888545554446665444444422.222222223333333333444556666655555444444444444444444 PP

     DUF5427 113 qeaekkeeeeeeaeeeead 131
                  e++k++  ee+++  +++
  EFC35251.1 286 IENKKRKYYEEKQD--NEP 302
                 44444422222222..222 PP

>> Neur_chan_memb  Neurotransmitter-gated ion-channel transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   8.6    0.0033        10     146     208 ..     217     279 ..     152     328 .. 0.56

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0033
                     ---------------SS---TTGGG--.....-----TTTTTHHHHHHHHHHHHHHHHHHHHH CS
  Neur_chan_memb 146 klseeqgsekastckckckegeeaspstqlskeelspelkkavegvkyiadhlraededksvk 208
                     + +ee+  e++ ++k ++k+++e ++ ++ +k+++++++k a e+ + i ++ ++++++++++
      EFC35251.1 217 DEEEESRLEEERKKKEEEKRKQEEKKRNEEEKRKKEEAIKIAKEEKRRIEEERKRKQDENQES 279
                     333333333333333333333333333333444444444444444444444443333333332 PP

>> RR_TM4-6  Ryanodine Receptor TM 4-6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3  26.4    0.0051        15      53     155 ..     192     299 ..     169     321 .. 0.48

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0051
                 XXXXXXXX...XXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXX...XXXX.XXXXXXXXXXXXXXXX..........XXXXXXXXX CS
    RR_TM4-6  53 kkeggqykvvakkseagLgDlseteaeespt..pelkkklaeeeeaeeekeeeeep...eaeaeekadaengekeekekekeeeekeseeeeeekkkkk 146
                 +ke+ ++++  ++  + + D+++   ee+ +   e++kk++ee+ ++eek+++ee+   ++ea++ a++e++  ee++k+k++e++es+ + ee + kk
  EFC35251.1 192 EKENDETEINDNEDVGYMNDIDDRCDEEEESrlEEERKKKEEEKRKQEEKKRNEEEkrkKEEAIKIAKEEKRRIEEERKRKQDENQESRRKREEIENKK 290
                 455555555666666566777776666665554333333333333333333333330003333333344444333333333333333333333333333 PP

                 XXXXXXXXX CS
    RR_TM4-6 147 kakskkkee 155
                 ++ +++k+ 
  EFC35251.1 291 RKYYEEKQD 299
                 333333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3378  (0.18841); expected 358.6 (0.02)
Passed bias filter:                      926  (0.0516482); expected 358.6 (0.02)
Passed Vit filter:                       384  (0.0214178); expected 17.9 (0.001)
Passed Fwd filter:                        83  (0.00462937); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.28u 0.41s 00:00:01.69 Elapsed: 00:00:00.57
# Mc/sec: 1992.13
//
Query:       EFC35252.1  [L=152]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       415  (0.0231469); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 876.65
//
Query:       EFC35253.1  [L=278]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-59  201.0   0.2    1.4e-59  200.8   0.2    1.1  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
     0.0057   16.1   0.2     0.0091   15.4   0.2    1.3  1  HNOBA          Heme NO binding associated


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  200.8   0.2   1.6e-63   1.4e-59       3     182 ..      43     223 ..      41     224 .. 0.98

  Alignments for each domain:
  == domain 1  score: 200.8 bits;  conditional E-value: 1.6e-63
  Guanylate_cyc   3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevavesk 97 
                    ae++ +vti+F+d+vgft++ss +++ ++v +Ln+++++fd+l++++ + k+ktiGday +vsg++ +++ +h ++++++a+ + + l+ ++++  
     EFC35253.1  43 AEKFADVTIFFSDMVGFTKMSSGMEADQLVMMLNTIVNEFDKLTEKYLIDKIKTIGDAYFAVSGTHsSKSSDHPERMLKFAISVYSFLRDFNIKFG 138
                    67899*************************************************************788999************************ PP

  Guanylate_cyc  98 eglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182
                    +++++r+G+htGp+v gviG+kk+ yd+wG+t+n+Asrmestg++g+iq+s++tye   + ++e++er++++vkGkg+++ty+l+
     EFC35253.1 139 KEVNLRIGMHTGPCVGGVIGTKKFAYDLWGDTINTASRMESTGVPGRIQISRATYERVFDLGYEFEERESIYVKGKGEMKTYLLK 223
                    **********************************************************************************997 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.2     1e-06    0.0091     190     221 .]       4      35 ..       1      35 [. 0.92

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 1e-06
       HNOBA 190 eLeesmkeleeekkrtdeLLysmiPkevAerL 221
                 + ++  + l eekk+++eLL +++P  vA+rL
  EFC35253.1   4 QVKKHASLLGEEKKKSEELLLNILPLPVANRL 35 
                 67888999**********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (278 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       402  (0.0224218); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1693.42
//
Query:       EFC35254.1  [L=273]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0075   16.0  36.2      0.082   12.5  18.3    3.2  2  DUF4045          Domain of unknown function (DUF4045)
  ------ inclusion threshold ------
      0.082   13.3   0.1         40    4.7   0.0    3.4  3  Acylphosphatase  Acylphosphatase
       0.11   12.1   0.6         15    5.2   0.1    3.9  5  THB              Tri-helix bundle domain


Domain annotation for each model (and alignments):
>> DUF4045  Domain of unknown function (DUF4045)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5  18.3   1.4e-05     0.082     220     355 ..      16     151 ..       1     161 [. 0.49
   2 !    5.2  21.0    0.0023        14     191     351 ..      99     272 ..      99     273 .] 0.45

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.4e-05
     DUF4045 220 kssvsgasaeaskakeeaseeaekestekeespapasseeskesekeeekeseeekapsk.kaeaseekkeeeeesepeeeeerkeapsllsptskaes 317
                 ++s+s+    + ++ + +s+ ++kest++ ++ a +s ++ ++ +++++++s++ ++ps+ + + +++ k++++ s++++++   ++  ++++++++++
  EFC35254.1  16 NTSSSSVGGGSVQQVDFRSALKKKESTSNLNTSA-TSPNTINTINTNTSNTSNSVNTPSSgQIDFRSNLKKKDQPSSSSTTQP--SSIDTTKSNNNNTI 111
                 1111111111222222222223334444333333.334444555566667777777777744444444444444444444444..44555555555556 PP

     DUF4045 318 dkpls..kserdsllkkpkpqspvkkDFRanLkkrevake 355
                 + p s  + ++ s++++ ++ s ++ DFR+nLkk+   + 
  EFC35254.1 112 TPPPSttTRTTTSPNTNNNTGSGTQVDFRSNLKKKTEDQS 151
                 66655445556666677777788889*******9865443 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0023
     DUF4045 191 svDlgrpssfkevs..pvglkrsea.pgshskkssvsgas..aeaskakeeas...........eeaekestekeespapasseeskesekeeekesee 273
                 s+D +++++ ++ +  p +  r++  p++++++ s ++    ++ +k++e++s            ++++  ++k ++p p++++++     ++ + +++
  EFC35254.1  99 SIDTTKSNNNNTITppPSTTTRTTTsPNTNNNTGSGTQVDfrSNLKKKTEDQSntsppsvqvvqDKKNEIPPSKPSNPPPSTTATTGGGGVQQVDFRSQ 197
                 567766666666663223333332214444444444444354333333333333444444443212222333333334444444444444222222222 PP

     DUF4045 274 ekapskkaeaseekkeeeeesepeeeeerkeapsllsptskaesdkplskserdsllkkpkpqspvkkDFRanLkkre 351
                  k+ +++++++++++++ ++  p ++++ +++p +++p s+  s+ p s++++++ ++     ++ + DFR+ Lkkr+
  EFC35254.1 198 LKNKTSNTTTPTSTTTPVTTPPPIKSTT-TTTPVTTTPPSSV-SSTP-STPTSGAAVTANSAGEAQQVDFRSILKKRK 272
                 2222222344444444444444433333.6666666666654.4555.57777777777777778888********97 PP

>> Acylphosphatase  Acylphosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0    0.0067        40       7      21 ..      25      39 ..      21      50 .. 0.85
   2 ?    3.8   0.0     0.013        77       7      22 ..     187     202 ..     183     206 .. 0.86
   3 ?   -0.2   0.0      0.23   1.4e+03       6      20 ..     256     270 ..     251     271 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0067
  Acylphosphatase  7 GrVQgvgFRkfvrrl 21
                     G VQ+v FR  ++++
       EFC35254.1 25 GSVQQVDFRSALKKK 39
                     89*******999875 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.013
  Acylphosphatase   7 GrVQgvgFRkfvrrlA 22 
                      G VQ+v FR  ++++ 
       EFC35254.1 187 GGVQQVDFRSQLKNKT 202
                      89********999875 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.23
  Acylphosphatase   6 tGrVQgvgFRkfvrr 20 
                       G+ Q+v FR  +++
       EFC35254.1 256 AGEAQQVDFRSILKK 270
                      5899******98875 PP

>> THB  Tri-helix bundle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.08   4.8e+02      24      32 ..      30      38 ..      30      38 .. 0.92
   2 ?   -0.5   0.0      0.16   9.4e+02      23      32 ..      76      85 ..      75      85 .. 0.83
   3 ?   -0.8   0.0       0.2   1.2e+03      24      32 ..     137     145 ..     137     145 .. 0.89
   4 ?   -1.7   0.0      0.38   2.3e+03      24      31 ..     192     199 ..     192     200 .. 0.85
   5 ?    5.2   0.1    0.0026        15      24      32 ..     262     270 ..     261     272 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.08
         THB 24 tDlRGmLkr 32
                +D+R  Lk+
  EFC35254.1 30 VDFRSALKK 38
                7******98 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.16
         THB 23 itDlRGmLkr 32
                 +D+R  Lk+
  EFC35254.1 76 QIDFRSNLKK 85
                58***99997 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.2
         THB  24 tDlRGmLkr 32 
                 +D+R  Lk+
  EFC35254.1 137 VDFRSNLKK 145
                 7***99997 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.38
         THB  24 tDlRGmLk 31 
                 +D+R  Lk
  EFC35254.1 192 VDFRSQLK 199
                 7***9888 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.0026
         THB  24 tDlRGmLkr 32 
                 +D+R +Lk+
  EFC35254.1 262 VDFRSILKK 270
                 7*******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (273 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1336  (0.0745161); expected 358.6 (0.02)
Passed bias filter:                      251  (0.0139997); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.89u 0.36s 00:00:01.25 Elapsed: 00:00:00.54
# Mc/sec: 1525.30
//
Query:       EFC35255.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.011   15.7   1.0      0.011   15.7   1.0    1.8  2  IL2          Interleukin 2
        1.5    8.6  15.6        1.7    8.4  15.6    1.1  1  RR_TM4-6     Ryanodine Receptor TM 4-6
        3.4    8.2   9.9        8.3    7.0   9.9    1.8  1  ANAPC1       Anaphase-promoting complex subunit 1
        5.7    5.7  10.4        7.4    5.3  10.4    1.2  1  ALMT         Aluminium activated malate transporter
        8.6    7.0  10.9          6    7.5   9.2    1.7  1  PFEMP        PFEMP DBL domain


Domain annotation for each model (and alignments):
>> IL2  Interleukin 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.2      0.52   1.9e+03      48      62 ..      37      51 ..      11      84 .. 0.58
   2 ?   15.7   1.0   3.1e-06     0.011      12      52 ..     120     158 .]     118     158 .] 0.84

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.52
                --HHHHTCEEEE-BS CS
         IL2 48 lklsrmltfklylPk 62
                ++ srml+ ++   +
  EFC35255.1 37 KQQSRMLKGRFGKQQ 51
                444555554444333 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 3.1e-06
                 XXXXXXXXXXXXXXXHHHHHHHHHHHHHHHHHHBTT--HHH CS
         IL2  12 ansaPtssstketqqqleqllldlqlllekvknyknlklsr 52 
                 +n  Ptssst    +q  q l+dl+ +l+ +k ++n+kl++
  EFC35255.1 120 TNQQPTSSSTT--TDQTIQTLVDLRNILDSIKSTRNRKLTM 158
                 6789****985..455567789****************985 PP

>> RR_TM4-6  Ryanodine Receptor TM 4-6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4  15.6   0.00047       1.7      20     138 ..      18     129 ..       2     150 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00047
                 XXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXX CS
    RR_TM4-6  20 eeeeeesleedlae.aageeeeedllsdvfgldlkkeggqykvvakkseagLgDlseteaeesptpelkkklaeeeeaeeekeeeeepeaeaeekadae 117
                 +e+++  +++++++ ++++++++ +l+  fg   k++gg++    ++ ++ Lg++s+te+++++  +  +k     +++++++ + ++  ++ ++++++
  EFC35255.1  18 NEQQQGMGQSNMQTnSQQGKQQSRMLKGRFG---KQQGGMQMNNRQHMQPQLGNQSNTESSQQN--NRMQKAG--GMKKSRQQGNMQRGMNR-RSKHQQ 108
                 3333333445555445556666666666666...899999888999*************99995..3333332..34444444444444444.222333 PP

                 XXXXXXXXXX..........X CS
    RR_TM4-6 118 ngekeekekekeeeekeseee 138
                 ng+ +++++++++++  s+  
  EFC35255.1 109 NGQLNNQQQQETNQQPTSSST 129
                 333333333322222222222 PP

>> ANAPC1  Anaphase-promoting complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   9.9    0.0023       8.3      48     127 ..      55     150 ..       7     153 .. 0.69

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0023
      ANAPC1  48 qapprslrnpsappnsfldssspll....................tsssqtssqkttfstesrgspkrlsltlsstleskkdsslPslfsLtdPlsevg 126
                 q+ +r++ +p++ ++s ++ss++                      ++ + +++q+ ++++++++++++ ++++s+t    +d+ + +l+ L++ l+ ++
  EFC35255.1  55 QMNNRQHMQPQLGNQSNTESSQQNNrmqkaggmkksrqqgnmqrgMNRRSKHQQNGQLNNQQQQETNQQPTSSSTT----TDQTIQTLVDLRNILDSIK 149
                 788999******9**9**9999866778877777777776666664444455555555555555555555444444....4455668888888888776 PP

      ANAPC1 127 l 127
                  
  EFC35255.1 150 S 150
                 5 PP

>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3  10.4    0.0021       7.4     371     461 ..      52     148 ..       5     155 .. 0.38

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0021
        ALMT 371 ekkeeekeseskkeea..........eaveeaeseseksllkeskrslklskkesapaeeslee..kqlskeeelkelelaealslatfaslLielvar 457
                   ++ ++++      +          +++++++++ +k   ++++r++ + ++ +   ++++++   + ++++e+++   +++   + ++  L++l + 
  EFC35255.1  52 GGMQMNNRQ------HmqpqlgnqsnTESSQQNNRMQKAGGMKKSRQQGNMQRGMNRRSKHQQNgqLNNQQQQETNQQPTSSSTTTDQTIQTLVDLRNI 144
                 111111111......011222222222222222222222222222222222222222222222211222333334444455555666667777888777 PP

        ALMT 458 ldki 461
                 ld+i
  EFC35255.1 145 LDSI 148
                 7776 PP

>> PFEMP  PFEMP DBL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   9.2    0.0017         6      55     133 ..      41     122 ..      29     150 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0017
       PFEMP  55 ekikerfkkqeklkkreaektldeeldlklflekellkkeikeakkdvkelkk..lkelldeegkkaqaesaknee.addnk 133
                 + +k rf kq+   + ++ +  + +l +++  e++++++++++a +  k+ ++  +++ ++   k++q+ + +n++ +++n+
  EFC35255.1  41 RMLKGRFGKQQGGMQMNNRQHMQPQLGNQSNTESSQQNNRMQKAGGMKKSRQQgnMQRGMNRRSKHQQNGQLNNQQqQETNQ 122
                 66899*******9998888888888999999999999999999877655544311555555433333332222322222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2910  (0.162307); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.76u 0.44s 00:00:01.20 Elapsed: 00:00:00.57
# Mc/sec: 836.90
//
Query:       EFC35256.1  [L=157]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.4e-41  139.7   0.7    8.8e-41  139.2   0.7    1.2  1  Ras          Ras family
    1.7e-22   79.9   0.1    3.6e-22   78.8   0.1    1.5  1  Roc          Ras of Complex, Roc, domain of DAPkinase
      5e-12   45.6   0.9    6.5e-12   45.3   0.9    1.1  1  Arf          ADP-ribosylation factor family
    0.00014   21.4   0.2    0.00017   21.2   0.2    1.2  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    0.00042   19.7   0.2    0.00051   19.5   0.2    1.2  1  Gtr1_RagA    Gtr1/RagA G protein conserved region
  ------ inclusion threshold ------
      0.012   14.9   0.0      0.016   14.5   0.0    1.2  1  DNA_pol_E_B  DNA polymerase alpha/epsilon subunit B
      0.022   14.3   0.5       0.26   10.8   0.1    2.0  2  PRORP        Protein-only RNase P


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.2   0.7   3.4e-44   8.8e-41      43     160 ..       3     121 ..       1     123 [. 0.96

  Alignments for each domain:
  == domain 1  score: 139.2 bits;  conditional E-value: 3.4e-44
                 ETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHSTTTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHT.SEEEE CS
         Ras  43 vdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrvaeenvpivLvGnKvDleekravsteegeelakelg.lkfle 140
                  +gk+vkl+iwDTAGqe+f++++++yy++a+g+++vydit+r+sfen+++w++++k++a+ nv+++LvGnKvDle++r+v+++e++e+a++++    l+
  EFC35256.1   3 KNGKKVKLQIWDTAGQERFRTITTSYYKGAQGVIMVYDITQRKSFENLSTWLNDVKQYADPNVSLILVGNKVDLEDQRQVTENEANEWAQRNNiSVCLQ 101
                 5799*****************************************************************************************66789* PP

                 EBTTTTCTHHHHHHHHHHHH CS
         Ras 141 tSAktnenveeafeellrei 160
                 tSA ++ nv+ af+++++ i
  EFC35256.1 102 TSAMNSLNVDVAFDRMVDGI 121
                 **************998765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.8   0.1   1.4e-25   3.6e-22      51     120 .]       3      76 ..       1      76 [. 0.89

  Alignments for each domain:
  == domain 1  score: 78.8 bits;  conditional E-value: 1.4e-25
                 TTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHHHHHHHHHHHCS.SS-EEEEEE-TTT CS
         Roc  51 kkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlkeWlkelkkvag.kspvilvgnkiDl 120
                 k+ kkvkl+iWDtaGqerfr+++++y+++a+ +i+vyd   ++s+enl++Wl+++k++a+ +  +ilvgnk+Dl
  EFC35256.1   3 KNGKKVKLQIWDTAGQERFRTITTSYYKGAQGVIMVYDitqRKSFENLSTWLNDVKQYADpNVSLILVGNKVDL 76 
                 56789*********************************86444679************98356899******95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.3   0.9   2.5e-15   6.5e-12      56     171 ..       6     117 ..       2     121 .. 0.78

  Alignments for each domain:
  == domain 1  score: 45.3 bits;  conditional E-value: 2.5e-15
                 TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-..HHHHHHHTTGGGSSSSSSEE CS
         Arf  56 knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLkalleeeelkevallvlaNKqDlpeals..eeelrellgleelkgkrkle 152
                 k++k+++wD  Gqe+ R +  +Y++  ++vi v D ++r+ +e+ ++ L+ + +     +v l++++NK Dl+++ +  e+e +e  + ++++    ++
  EFC35256.1   6 KKVKLQIWDTAGQERFRTITTSYYKGAQGVIMVYDITQRKSFENLSTWLNDVKQYA-DPNVSLILVGNKVDLEDQRQvtENEANEWAQRNNIS----VC 99 
                 89***********************************************9986655.5689999********987550045555555555555....33 PP

                 EEEEBTTTTBTHHHHHHHH CS
         Arf 153 iqkcsavkgeglkeglewl 171
                   ++sa++  +++ +++++
  EFC35256.1 100 -LQTSAMNSLNVDVAFDRM 117
                 .345666666666666665 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.2   6.6e-08   0.00017      65     149 ..       3      90 ..       1     148 [. 0.69

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 6.6e-08
                 TTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB....STHHHHHHHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHH CS
    GTP_EFTU  65 ketkkylinliDtPGHvdFskevirglrvlDgavlvvdaveG....vepqteevlrlalkegvpiivfiNKmDrlkaelkeiveevkqk 149
                 k++kk ++++ Dt G + F   ++  ++ + g+++v d+++       +   + +++  + +v +i++ NK+D  +++ + + +e+++ 
  EFC35256.1   3 KNGKKVKLQIWDTAGQERFRTITTSYYKGAQGVIMVYDITQRksfeNLSTWLNDVKQYADPNVSLILVGNKVDLEDQR-QVTENEANEW 90 
                 67999***********************************884322222333445777778889*********97443.2333333322 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.2     2e-07   0.00051      46     138 ..       6      89 ..       2     132 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 2e-07
   Gtr1_RagA  46 gnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletlkeilealrqy.speakvfvlihKmDliqedereeifeerke 138
                 ++++l++wD  Gqe+f + +      + ++  + +i V D++    ++++e+l++ l+ ++qy +p++++    +K+Dl ++++ +e  +e +e
  EFC35256.1   6 KKVKLQIWDTAGQERFRTIT-----TSYYKGAQGVIMVYDIT---QRKSFENLSTWLNDVKQYaDPNVSLILVGNKVDLEDQRQVTE--NEANE 89 
                 6899***********98886.....5678888999*******...67889999999999999845888888888****985443332..22222 PP

>> DNA_pol_E_B  DNA polymerase alpha/epsilon subunit B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   6.4e-06     0.016      10      77 ..      42     108 ..      37     125 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6.4e-06
                  -TT----HHHHHHHHHHH.HTT--SEEEEES-SSBTTSHHHHHT---S--SSHHHHHHHHTHHHHTTS CS
  DNA_pol_E_B  10 dndnrsleaLrkiLqgyapeesppdvlilaGnfvdaahkaiasskvstdekkenfdalalllsilesl 77 
                  + + +s+e+L+++L+ +++ ++p + lil+Gn vd + + + +++ +++ ++ n+ ++ l +s+++sl
   EFC35256.1  42 T-QRKSFENLSTWLNDVKQYADPNVSLILVGNKVDLEDQRQVTENEANEWAQRNNISVCLQTSAMNSL 108
                  3.8899************99999999*********999998887776556666666666666666665 PP

>> PRORP  Protein-only RNase P
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1    0.0001      0.26      70     132 ..      35      96 ..      18     107 .. 0.80
   2 ?    2.2   0.0     0.042   1.1e+02      59     106 ..     110     157 .]     102     157 .] 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0001
       PRORP  70 lnvaklvkkkkesivkaqallevvrqlakqklrllvlgrkhmlkekskwekkelekikeaaal 132
                 + + + ++++k+ ++++ + l+ v+q+a  +++l+++g+k  l++++++ ++e +++ +++++
  EFC35256.1  35 VIMVYDITQRKS-FENLSTWLNDVKQYADPNVSLILVGNKVDLEDQRQVTENEANEWAQRNNI 96 
                 555455555555.899999*********************999******99999999887665 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.042
       PRORP  59 ktlpfdiviDglnvaklvkkkkesivkaqallevvrqlakq.klrllvl 106
                    +fd ++Dg+   ++++++ ++ +k  + ++   q++k+ ++r+l+l
  EFC35256.1 110 VDVAFDRMVDGIFE-HSFENSLSAPKKETVKINNNDQVVKKpSKRCLIL 157
                 5678*******988.7777777767776666777777777779999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (157 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       845  (0.0471303); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 983.75
//
Query:       EFC35257.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       638  (0.0355848); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.37s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 664.52
//
Query:       EFC35258.1  [L=317]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.016   14.9   0.0      0.038   13.7   0.0    1.6  1  DUF4364   Domain of unknown function (DUF4364)


Domain annotation for each model (and alignments):
>> DUF4364  Domain of unknown function (DUF4364)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   2.1e-06     0.038      46     129 ..     212     298 ..     207     302 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.1e-06
     DUF4364  46 sglieeeek..enktlykiTekGketlelfenripksirekideylkenkeelkkesevkad.yykkengeytVklkikekdstlle 129
                  +++ee+e+  ++++++ + ++G+  + +f n+ip++i +++ e ++  + e k +++  +    ++  ++ ++   i+++++tll+
  EFC35258.1 212 RDHVEEHEEcnRKTNMIMLRPDGSMDAAYFPNSIPNNICDEMTEIVELSNIEPKDQKQAIIGgTWNRYGNSIEIVAGISDENNTLLD 298
                 5677776544488999******************************99888887776655540445555677788888888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       495  (0.0276089); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 2180.66
//
Query:       EFC35259.1  [L=177]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.8e-69  231.0   0.0    4.4e-69  230.8   0.0    1.0  1  S-AdoMet_synt_C  S-adenosylmethionine synthetase, C-terminal 
     0.0071   16.6   0.0      0.012   15.9   0.0    1.4  1  S-AdoMet_synt_M  S-adenosylmethionine synthetase, central dom


Domain annotation for each model (and alignments):
>> S-AdoMet_synt_C  S-adenosylmethionine synthetase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  230.8   0.0   4.9e-73   4.4e-69       1     138 []      32     171 ..      32     171 .. 0.98

  Alignments for each domain:
  == domain 1  score: 230.8 bits;  conditional E-value: 4.9e-73
                      S-TTTTS-EETTS-TTTTTTTTSS---S---TTB-TTSHHHHHHHHHHHHHHHHHHTTSBSEEEEEEEE-TT-SS-SEEEEEE-S-BSS..-HH CS
  S-AdoMet_synt_C   1 iGgpkgdaGltgrkiivdtYgglaahgggafsgKdptkvDrsaayaaryvaknlvaaglakkvevqlsYaigvaepvsisvetfgtekv..see 92 
                      iGgp+gdaGltgrkiivdtYgg++ahgggafsgKdp+kvDrsa+yaar+vak++vaaglak+++vq++Yaig+a+p+s++v+t+gt+    +++
       EFC35259.1  32 IGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSASYAARWVAKSVVAAGLAKRCLVQVAYAIGIAHPLSVHVDTYGTALNgkTDA 125
                      8*************************************************************************************7544499* PP

                      HHHHHHHHH----HHHHHHHHTTTSS--TGGGSS-SSS--T-TTS. CS
  S-AdoMet_synt_C  93 eiaeivkevfdlrpaaiieeldLkkpiykktaayghfgreelpwek 138
                      +i +iv+++fdlrp +ii++l+L +piy+ taayghfgr+e+pwe+
       EFC35259.1 126 DILAIVNKNFDLRPYHIIKDLNLMNPIYSPTAAYGHFGRSEFPWEQ 171
                      *********************************************7 PP

>> S-AdoMet_synt_M  S-adenosylmethionine synthetase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   1.3e-06     0.012      91     120 .]       2      30 ..       1      30 [. 0.92

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.3e-06
  S-AdoMet_synt_M  91 lkekvikkvlkeelldekktkllinptGkF 120
                      lke+vi +v++++lld+  t +++np+G+F
       EFC35259.1   2 LKEHVIVPVIPANLLDDA-TIYHLNPSGRF 30 
                      799********9999885.**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       228  (0.0127168); expected 358.6 (0.02)
Passed bias filter:                      206  (0.0114898); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.29s 00:00:00.73 Elapsed: 00:00:00.47
# Mc/sec: 1142.68
//
Query:       EFC35260.1  [L=214]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       739  (0.0412181); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 1451.58
//
Query:       EFC35261.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00012   22.9   0.0     0.0002   22.2   0.0    1.3  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.0   1.1e-08    0.0002       9      94 ..     104     182 ..      97     184 .. 0.79

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 1.1e-08
                     T-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--EEE..............---TT-EEEEE-..B-TEEE--B.-SS-EEEEEEE CS
  2OG-FeII_Oxy_3   9 gqeykpHvDnfekeegsgqrrltvllyLnekeseeGGelelyekdk....eavkikpkkgrlvlFesdellpHevlpvtkggeRlsltgw 94 
                      + y++H+D        ++  + vl+++   +++eGG+l +  + +    +  +++ + g+lv+ +s++ + H+v++vt+g  R  l+++
      EFC35261.1 104 VKPYRKHIDP-------NNNGMDVLMFFG--KTFEGGNLIVSYHYTnidfRMFTLPIQSGDLVFLNSRIYH-HKVTKVTSG-VRCGLVFF 182
                     456999***4.......246688999995..68*****9996666588888888888**********8775.******886.99988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1159  (0.0646439); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1674.93
//
Query:       EFC35262.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       352  (0.019633); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 1122.56
//
Query:       EFC35263.1  [L=359]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.087   12.8   0.8       0.22   11.5   0.8    1.6  1  RHH_1     Ribbon-helix-helix protein, copG family


Domain annotation for each model (and alignments):
>> RHH_1  Ribbon-helix-helix protein, copG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.8   1.2e-05      0.22       6      36 ..     309     340 ..     309     342 .. 0.95

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1.2e-05
                 EEHHHHHHHHHHHHHHT.SSHHHHHHHHHHHH CS
       RHH_1   6 ldeellerLdelarrrg.rSrSelIReAlrey 36 
                 ld ++++ L++l  +++  S ++++R++lre+
  EFC35263.1 309 LDNDEDDSLEQLEQATEeISLHYHLRRLLRER 340
                 7899**************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (359 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       989  (0.055162); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 2136.78
//
Query:       EFC35264.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       639  (0.0356406); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1169.28
//
Query:       EFC35265.1  [L=127]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00026   19.9   0.2     0.0003   19.6   0.2    1.1  1  DUF3808   Protein of unknown function (DUF3808)
     0.0047   17.6   0.1         31    5.7   0.0    3.5  4  TPR_14    Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.022   15.3   0.1       0.37   11.3   0.0    2.1  2  TPR_19    Tetratricopeptide repeat
      0.029   14.1   0.3      0.034   13.9   0.3    1.2  1  DUF1955   Domain of unknown function (DUF1955)
      0.056   14.1   0.4        1.3    9.9   0.1    2.7  3  TPR_6     Tetratricopeptide repeat
        0.1   12.8   0.1       0.22   11.8   0.1    1.4  1  TPR_5     Tetratrico peptide repeat


Domain annotation for each model (and alignments):
>> DUF3808  Protein of unknown function (DUF3808)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.2     1e-07    0.0003     260     332 ..      33     102 ..      11     108 .. 0.85

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 1e-07
     DUF3808 260 ksrkrfPksalwllfearieslkgnldeAlelleeiieesqselkqvkhlclfelaltlvylheykeaaesfl 332
                  +++++P+s+++l f+a i++  g+ +e+++l+++++   +++  +++  +l  l+++l   h+yk+ ae  +
  EFC35265.1  33 AMLQKYPESSVFLSFKALILMNLGKRKESIQLVDDVL---AQKKMEFHDFILRTLSMALEKVHDYKRIAELYE 102
                 57889*****************************876...566668*******************99887665 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.025        73      19      38 ..      26      45 ..      13      51 .. 0.79
   2 ?    5.7   0.0      0.01        31       8      30 ..      49      71 ..      44      74 .. 0.91
   3 ?    0.6   0.0      0.47   1.4e+03       7      27 ..      84     104 ..      80     114 .. 0.74
   4 ?    3.5   0.0     0.054   1.6e+02       6      30 ..      96     122 ..      91     123 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.025
      TPR_14 19 eAiallrralalaPddaeaw 38
                 A++ ++++l+++P++ +++
  EFC35265.1 26 NALKECDAMLQKYPESSVFL 45
                5999**********998766 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.01
      TPR_14  8 aeallalGdpdeAiallrralal 30
                a +l++lG+ +e+i+l +++la+
  EFC35265.1 49 ALILMNLGKRKESIQLVDDVLAQ 71
                6789****************996 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.47
      TPR_14   7 laeallalGdpdeAiallrra 27 
                 l  al+   d+++ ++l++++
  EFC35265.1  84 LSMALEKVHDYKRIAELYEKV 104
                 566778888888888988876 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.054
      TPR_14   6 alaeallalGd..pdeAiallrralal 30 
                 ++ae+++   +  p++Ai+ +++++++
  EFC35265.1  96 RIAELYEKVYNaiPAQAITQYEDVIEK 122
                 5666666655555899*******9987 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00013      0.37       8      56 ..      25      73 ..      18      80 .. 0.90
   2 ?    2.0   0.1     0.098   2.9e+02       6      25 ..      93     112 ..      86     119 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00013
      TPR_19  8 aeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedp 56
                 +Al+   ++lq++p+++  +   A +l++lg  +e ++l+d+++++++
  EFC35265.1 25 VNALKECDAMLQKYPESSVFLSFKALILMNLGKRKESIQLVDDVLAQKK 73
                58999999***********************************999875 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.098
      TPR_19   6 dyaeAlalleqalqedpkna 25 
                 dy + ++l+e+++ + p +a
  EFC35265.1  93 DYKRIAELYEKVYNAIPAQA 112
                 89999******998888765 PP

>> DUF1955  Domain of unknown function (DUF1955)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.3   1.1e-05     0.034      68     144 ..      21     104 ..       7     119 .. 0.67

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.1e-05
                 G-S-THHHHHHHHHTT--...-HHHHHHHHHHHHTT-HHH....HHHHHHHH---S-HHHHHHHHHHHHHTT-HHHHHHHHHHH CS
     DUF1955  68 kcqnlkrviecyvklnkl...seyvdlaldvlvkkgkkdq....ldkilkelkneikaelllkianalkklgdereanellkka 144
                 + +++  + ec ++l+k+   s ++     +l++ gk+ +    +d++l++ k e +  +l  ++ al+k++d +   el +k 
  EFC35265.1  21 ERKDVNALKECDAMLQKYpesSVFLSFKALILMNLGKRKEsiqlVDDVLAQKKMEFHDFILRTLSMALEKVHDYKRIAELYEKV 104
                 5556666667776666651114455544444455554433122246777777888999999****************9998876 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.26   7.9e+02      20      33 .]      28      41 ..      21      41 .. 0.73
   2 ?    0.9   0.0      0.31   9.3e+02       8      26 ..      86     104 ..      84     107 .. 0.73
   3 ?    9.9   0.1   0.00042       1.3       5      30 ..      96     123 ..      96     123 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.26
                HHHHHHHHHH-TT- CS
       TPR_6 20 lealerlikeYPdS 33
                l+  +  +++YP+S
  EFC35265.1 28 LKECDAMLQKYPES 41
                5555666899**98 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.31
                 HHHHH.HHHHHHHHHHHHHH CS
       TPR_6   8 lsyrk.lgdtdkAlealerl 26 
                 ++++k   d+ +  e++e++
  EFC35265.1  86 MALEKvH-DYKRIAELYEKV 104
                 6677767.888888888887 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00042
                 HHHHHHHH.HH.HHHHHHHHHHHHHHH- CS
       TPR_6   5 klalsyrk.lg.dtdkAlealerlikeY 30 
                 ++a++y+k  +  +++A++ +e++i++Y
  EFC35265.1  96 RIAELYEKvYNaIPAQAITQYEDVIEKY 123
                 688999987766888************9 PP

>> TPR_5  Tetratrico peptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   7.2e-05      0.22      48     115 ..      52     123 ..      48     127 .] 0.77

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 7.2e-05
       TPR_5  48 LRnlGeaeealaLLraeleapsdelddalaaflaLvLs...dlgrereavsivllal.aehlprYqRsvtnY 115
                 L nlG+ +e+++L+++ l++++ e++d +  +l+++L    d +r +e    v +a+ a+ +++Y   ++ Y
  EFC35265.1  52 LMNLGKRKESIQLVDDVLAQKKMEFHDFILRTLSMALEkvhDYKRIAELYEKVYNAIpAQAITQYEDVIEKY 123
                 78***************************9999888851125566777777777777566677777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.43u 0.34s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 814.22
//
Query:       EFC35266.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        3.3    6.5   5.9        3.6    6.4   5.9    1.1  1  LMBR1     LMBR1-like membrane protein


Domain annotation for each model (and alignments):
>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   5.9    0.0002       3.6     229     325 ..      12     151 ..       2     170 .. 0.60

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0002
       LMBR1 229 evkklrksisesdp.lrkyleeilk...........................kvPeeiaeklks................nenkteeslaklekqlika 283
                 ++k+ +++ ++sd+ l+++++  l+                           k+P+ + + ++s                ++n+  ++ a+++ +l + 
  EFC35266.1  12 KAKNRQEQNNQSDEsLERVIDGFLSvpnvkqriiaklveqgevkeispwseeKSPQRADDVVNSilrensidfndnsnsmDSNSLDSNSADSNDSLRYD 110
                 444555555555544555555555566666666666666777777777777766666666666677777776666665574444455556666666666 PP

       LMBR1 284 lqkrertekqwkrllekalelediiknksskekefkssessr 325
                  q++++++ + +   +++    d+ ++++++e++f +  ++r
  EFC35266.1 111 HQQEQQEQFEQYGEQDEQ-YSGDMNEQMQQEEEQFGRRGRRR 151
                 666666666666666666.56666666888888887654443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1747  (0.0974399); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1081.17
//
Query:       EFC35267.1  [L=366]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      313  (0.0174578); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.24s 00:00:00.76 Elapsed: 00:00:00.43
# Mc/sec: 2551.03
//
Query:       EFC35268.1  [L=243]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-21   75.7   2.0    7.4e-06   25.7   0.0    4.9  4  NHL             NHL repeat
      0.007   15.4   2.1         11    4.9   0.0    3.6  4  Peptidase_C107  Viral cysteine endopeptidase C107
     0.0084   15.7   0.2        1.7    8.2   0.0    2.6  3  SGL             SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.059   13.7   0.5        5.2    7.5   0.0    3.2  4  ComGF           Putative Competence protein ComGF
       0.49   10.8   3.6        8.2    6.9   0.0    3.7  5  Linker_histone  linker histone H1 and H5 family
        1.4    9.3   5.3        4.9    7.6   0.1    3.7  4  YdfZ            YdfZ protein


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   0.0   2.5e-09   7.4e-06       1      27 [.      31      57 ..      31      58 .. 0.96
   2 !   21.0   0.0   8.1e-08   0.00024       1      27 [.      87     113 ..      87     114 .. 0.95
   3 !   13.1   0.0   2.5e-05     0.076       7      27 ..     148     168 ..     142     169 .. 0.83
   4 !   11.8   0.0   6.4e-05      0.19       1      24 [.     198     221 ..     198     221 .. 0.95

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 2.5e-09
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +nyP+Gv v++n+++++aD +n+r+++
  EFC35268.1 31 LNYPSGVFVSTNNEVFIADKNNNRIRK 57
                79***********************97 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 8.1e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 ++yP++v v++n++i++aD+ nhr+++
  EFC35268.1  87 LYYPQSVFVSTNNEICIADTFNHRIRK 113
                 79***********************97 PP

  == domain 3  score: 13.1 bits;  conditional E-value: 2.5e-05
                 EEEETTTEEEEEECCCTEEEE CS
         NHL   7 vavdsnGdiyVaDsenhrvqv 27 
                 v v+ n+++y+aD+ nh++++
  EFC35268.1 148 VFVSANNEVYIADTFNHSIRK 168
                 55789*************986 PP

  == domain 4  score: 11.8 bits;  conditional E-value: 6.4e-05
                 BSSEEEEEEETTTEEEEEECCCTE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhr 24 
                 +n+P+Gv +++n +iy+++++nh+
  EFC35268.1 198 LNHPSGVFISTNYEIYITETNNHT 221
                 799********************5 PP

>> Peptidase_C107  Viral cysteine endopeptidase C107
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.9   0.0    0.0038        11     183     215 ..      21      53 ..      16      68 .. 0.85
   2 ?    3.2   0.0     0.012        35     184     216 ..      78     110 ..      61     121 .. 0.83
   3 ?   -1.2   0.0      0.26   7.9e+02     189     215 ..     138     164 ..     131     170 .. 0.81
   4 !    4.5   0.0    0.0048        14     188     215 ..     193     220 ..     185     232 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0038
                     TB--TTTT--S---EEEEE-TTS-BSSSSGGGT CS
  Peptidase_C107 183 gksniwtsyklqhpseimitlnneinlpnpany 215
                     g + + ts +l++ps ++++ nne+ + +  n 
      EFC35268.1  21 GDNGLATSAQLNYPSGVFVSTNNEVFIADKNNN 53 
                     5667889******************99887775 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.012
                     B--TTTT--S---EEEEE-TTS-BSSSSGGGTT CS
  Peptidase_C107 184 ksniwtsyklqhpseimitlnneinlpnpanyd 216
                      +   ts +l +p  ++++ nnei + +  n+ 
      EFC35268.1  78 DNGSATSSQLYYPQSVFVSTNNEICIADTFNHR 110
                     44567999****************999887765 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.26
                     TT--S---EEEEE-TTS-BSSSSGGGT CS
  Peptidase_C107 189 tsyklqhpseimitlnneinlpnpany 215
                     t+ +l++p  ++++ nne+ + +  n+
      EFC35268.1 138 TTAQLHRPYSVFVSANNEVYIADTFNH 164
                     677899999999999**9999887776 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.0048
                     TTT--S---EEEEE-TTS-BSSSSGGGT CS
  Peptidase_C107 188 wtsyklqhpseimitlnneinlpnpany 215
                      t+ +l+hps ++i+ n ei + +  n+
      EFC35268.1 193 ATNAQLNHPSGVFISTNYEIYITETNNH 220
                     57889****************9988876 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.013        38     183     217 ..      31      65 ..       8      72 .. 0.84
   2 !    7.7   0.0   0.00078       2.3     146     217 ..      99     175 ..      81     184 .. 0.83
   3 !    8.2   0.0   0.00057       1.7     143     218 ..     151     233 ..     139     236 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.013
         SGL 183 egepDGlavDaeGnvwvAvwgggkvvrfdpdGkli 217
                  ++p G++v  +++v++A  ++++++++ ++G+++
  EFC35268.1  31 LNYPSGVFVSTNNEVFIADKNNNRIRKIVKNGNIV 65 
                 36899***********************9999865 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00078
         SGL 146 ktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGkli 217
                 + + +aD+ +++i +++  +  +  +n ++ + +++g+       +p +++v a+++v++A   ++ ++++d+ G+ i
  EFC35268.1  99 NEICIADTFNHRIRKIENGRIVTIAGNGQPGYSGDNGPattaqlHRPYSVFVSANNEVYIADTFNHSIRKIDESGN-I 175
                 4555689999999999988888888888888999999899988877999***********************9997.4 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00057
         SGL 143 pdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 ++++ +Y+aD+ +++i ++d + + +++   +   + ++ g       + p G+++  + +++++  ++++ +++ ++G++i+
  EFC35268.1 151 SANNEVYIADTFNHSIRKIDESGNIETIAGNEQPgYGGDGGYatnaqlNHPSGVFISTNYEIYITETNNHTTRKILENGNIIT 233
                 67889999999999999999998888877666653666666688888767999999999999999999999999999998875 PP

>> ComGF  Putative Competence protein ComGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.0    0.0018       5.2      42      72 ..      38      67 ..      25      69 .. 0.83
   2 ?   -3.5   0.0       4.6   1.4e+04      53      62 ..     105     114 ..      91     124 .. 0.52
   3 ?    0.5   0.0      0.26   7.7e+02      44      68 ..     151     174 ..     137     179 .. 0.68
   4 ?    1.3   0.1      0.15   4.5e+02      47      70 ..     209     232 ..     195     238 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0018
       ComGF 42 llkkekktityekynnkirkrvnggGyqplL 72
                 +++++++++ +k+nn irk+v ++G+++l+
  EFC35268.1 38 FVSTNNEVFIADKNNNRIRKIV-KNGNIVLI 67
                56889999999999999*9999.99998876 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 4.6
       ComGF  53 ekynnkirkr 62 
                 ++ n+ irk+
  EFC35268.1 105 DTFNHRIRKI 114
                 3334444443 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.26
       ComGF  44 kkekktityekynnkirkrvnggGy 68 
                 + ++++++ ++ n++irk+ +++G+
  EFC35268.1 151 SANNEVYIADTFNHSIRKI-DESGN 174
                 5566666666666666655.88887 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.15
       ComGF  47 kktityekynnkirkrvnggGyqp 70 
                 + +i++ + nn++ +++ ++G+++
  EFC35268.1 209 NYEIYITETNNHTTRKILENGNII 232
                 445788888888888887777765 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.2       3.7   1.1e+04      53      69 ..       2      18 ..       1      18 [. 0.79
   2 ?    6.9   0.0    0.0027       8.2      43      69 ..      48      74 ..      30      76 .. 0.78
   3 ?   -1.2   0.0       0.9   2.7e+03      46      66 ..     107     126 ..      94     132 .. 0.62
   4 ?    0.0   0.0      0.38   1.1e+03      33      64 ..     153     180 ..     147     189 .. 0.72
   5 ?    1.1   0.0      0.18   5.2e+02      29      58 ..     205     230 ..     204     239 .. 0.57

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.7
  Linker_histone 53 gvekgelvqpkgkGasG 69
                     +++g +v + g+G +G
      EFC35268.1  2 ILKNGNIVTIAGNGKQG 18
                    57899999999988776 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0027
  Linker_histone 43 ksllkkalkkgvekgelvqpkgkGasG 69
                    +   ++ ++k v++g +v + g+G +G
      EFC35268.1 48 ADKNNNRIRKIVKNGNIVLIAGNGQTG 74
                    5555899***************99887 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.9
  Linker_histone  46 lkkalkkgvekgelvqpkgkG 66 
                     +++ ++k +e+g +v + g+G
      EFC35268.1 107 FNHRIRK-IENGRIVTIAGNG 126
                     4444444.6788888887766 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.38
  Linker_histone  33 kykvvdvskfksllkkalkkgvekgelvqpkg 64 
                     +++v     ++  +++ ++k  e+g ++ + g
      EFC35268.1 153 NNEV----YIADTFNHSIRKIDESGNIETIAG 180
                     4444....446678999999999999887764 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.18
  Linker_histone  29 yikakykvvdvskfksllkkalkkgvekge 58 
                     +i+++y++  ++ +++    + +k +e+g 
      EFC35268.1 205 FISTNYEIYITETNNH----TTRKILENGN 230
                     7889999853344444....4445555555 PP

>> YdfZ  YdfZ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.58   1.7e+03      10      25 ..       3      18 ..       2      20 .. 0.82
   2 ?    7.6   0.1    0.0017       4.9       5      26 ..      54      75 ..      47     101 .. 0.84
   3 ?    1.5   0.0      0.14     4e+02       9      26 ..     113     130 ..     105     158 .. 0.71
   4 ?   -1.9   0.1       1.6   4.7e+03       7      24 ..     223     240 ..     221     242 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.58
        YdfZ 10 ittGsrVMiagtgevg 25
                ++ G  V iag+g+ g
  EFC35268.1  3 LKNGNIVTIAGNGKQG 18
                6789999999999866 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0017
        YdfZ  5 RnrNaittGsrVMiagtgevgv 26
                R r  ++ G  V+iag+g++g 
  EFC35268.1 54 RIRKIVKNGNIVLIAGNGQTGC 75
                55666789************95 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.14
        YdfZ   9 aittGsrVMiagtgevgv 26 
                 +i+ G  V iag+g+ g 
  EFC35268.1 113 KIENGRIVTIAGNGQPGY 130
                 588899999999998764 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 1.6
        YdfZ   7 rNaittGsrVMiagtgev 24 
                 r  ++ G  + iag+g+ 
  EFC35268.1 223 RKILENGNIITIAGNGNE 240
                 556788999999999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       542  (0.0302304); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1491.76
//
Query:       EFC35269.1  [L=262]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (262 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1749.71
//
Query:       EFC35270.1  [L=247]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (247 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       348  (0.0194099); expected 358.6 (0.02)
Passed bias filter:                      304  (0.0169558); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.33s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 1438.24
//
Query:       EFC35271.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.7e-26   90.0  14.9     0.0012   18.7   0.0    8.8  9  LRR_6         Leucine Rich repeat
    1.6e-12   47.0  14.5    2.5e-06   27.1   0.7    3.9  4  LRR_8         Leucine rich repeat
    1.6e-12   47.4  21.3    0.00035   20.9   2.0    5.8  7  LRR_4         Leucine Rich repeats (2 copies)
      5e-06   26.3  13.2        3.1    8.7   0.1    7.1  7  LRR_1         Leucine Rich Repeat
     0.0003   20.3   1.6      0.076   12.5   0.1    2.5  3  LRR_9         Leucine-rich repeat
     0.0037   17.1   0.1         10    5.9   0.0    4.2  4  DUF4347       Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
       0.14   11.6   2.5        1.3    8.5   0.5    2.8  3  RNA_pol_I_TF  RNA polymerase I specific initiation factor


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.8e-06    0.0071       4      24 .]       3      23 ..       1      23 [. 0.86
   2 !   12.3   0.1   5.2e-05      0.13       5      20 ..      28      43 ..      25      46 .. 0.91
   3 ?   -1.2   0.0       1.1   2.9e+03       4      17 ..      51      64 ..      51      66 .. 0.86
   4 ?    1.6   0.0      0.14   3.6e+02       5      23 ..      75      93 ..      72      94 .. 0.87
   5 !   17.6   0.1   1.1e-06    0.0027       5      24 .]      99     118 ..      96     118 .. 0.91
   6 !   18.1   0.0   7.7e-07     0.002       5      21 ..     123     139 ..     120     141 .. 0.90
   7 ?    3.3   0.1      0.04     1e+02       5      19 ..     147     161 ..     146     166 .. 0.78
   8 !   18.7   0.0   4.7e-07    0.0012       5      24 .]     171     190 ..     168     190 .. 0.93
   9 ?    3.7   0.1     0.031        80      12      24 .]     202     214 ..     194     214 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.8e-06
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                 Lt L++s N+Ig+eG + ++
  EFC35271.1  3 QLTCLSVSNNNIGNEGFKFIC 23
                69**************77665 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 5.2e-05
       LRR_6  5 LteLdLsgNdIgDeGa 20
                Lt+Ld+  NdI+ +G+
  EFC35271.1 28 LTYLDVGRNDINSKGL 43
                9*************98 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.1
       LRR_6  4 hLteLdLsgNdIgD 17
                +L+ L + +N +gD
  EFC35271.1 51 KLKDLRIYYNSVGD 64
                58999999999999 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.14
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt L+++  +I+ +Ga+ +
  EFC35271.1 75 LTNLNVNTACINEKGAKFI 93
                999****999*99999977 PP

  == domain 5  score: 17.6 bits;  conditional E-value: 1.1e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 +t L++s+N+Ig++G+e ++
  EFC35271.1  99 VTNLNISFNEIGNQGLEHIS 118
                 689**************986 PP

  == domain 6  score: 18.1 bits;  conditional E-value: 7.7e-07
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt+L++++N+I+D G+ 
  EFC35271.1 123 LTHLNIQSNNIDDTGVY 139
                 9**************96 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.04
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt+Ld+s + Ig +G
  EFC35271.1 147 LTTLDISKHIIGEKG 161
                 9******98777666 PP

  == domain 8  score: 18.7 bits;  conditional E-value: 4.7e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s ++I+ eG++ ++
  EFC35271.1 171 LTHLDISECCIQYEGVKHIS 190
                 9****************986 PP

  == domain 9  score: 3.7 bits;  conditional E-value: 0.031
       LRR_6  12 gNdIgDeGaeaLa 24 
                  N++g  Ga++L+
  EFC35271.1 202 LNCFGKGGAKCLC 214
                 59**********8 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.8   2.9e-07   0.00075       1      59 [.       2      60 ..       2      62 .. 0.95
   2 !    8.1   0.3   0.00087       2.2      22      61 .]      70     109 ..      64     109 .. 0.91
   3 !   27.1   0.7   9.8e-10   2.5e-06       2      58 ..     122     178 ..     121     181 .. 0.96
   4 ?    3.0   0.0     0.034        87       2      51 ..     170     219 ..     169     223 .. 0.57

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 2.9e-07
                TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59
                ++Lt L++snN++ + + ++   +++L++Ld ++N +++   + + +L +L+ L + +N
  EFC35271.1  2 RQLTCLSVSNNNIGNEGFKFICEMKQLTYLDVGRNDINSKGLNHITNLDKLKDLRIYYN 60
                68999*************************************************99887 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00087
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + +++L+ L+ +  +++   ++ +s Lp ++ L++s N +
  EFC35271.1  70 SEMKQLTNLNVNTACINEKGAKFISELPLVTNLNISFNEI 109
                 67999********************************986 PP

  == domain 3  score: 27.1 bits;  conditional E-value: 9.8e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +Lt L++++N++ + +  + +gl +L++Ld+s   +     + +s +++L++Ld+s 
  EFC35271.1 122 QLTHLNIQSNNIDDTGVYFLHGLDQLTTLDISKHIIGEKGTKLLSEMEQLTHLDISE 178
                 79****************************************************996 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.034
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsL 51 
                 +Lt Ld+s   ++  + +  + ++nL++ ++  N+     ++++  +++L
  EFC35271.1 170 QLTHLDISECCIQYEGVKHISEMKNLTYPNICLNCFGKGGAKCLCEMKNL 219
                 45566666666666666666666666666666666666555555555555 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   2.0   1.4e-07   0.00035       2      43 ..       3      53 ..       2      54 .. 0.81
   2 !    6.3   0.5    0.0053        14       2      31 ..      51      81 ..      42      88 .. 0.76
   3 ?    2.7   0.3     0.071   1.8e+02      21      36 ..      95     109 ..      84     116 .. 0.75
   4 !   14.9   2.5   1.1e-05     0.027       3      37 ..      99     134 ..      97     137 .. 0.76
   5 !   20.3   0.6     2e-07   0.00052       1      32 [.     121     154 ..     121     160 .. 0.89
   6 !    8.5   0.0    0.0011       2.8       2      27 ..     170     197 ..     169     207 .. 0.77
   7 ?   -3.1   0.0       4.8   1.2e+04       1       6 [.     217     222 ..     214     223 .. 0.52

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 1.4e-07
                S--EEE--SS---E-S-.HH.H-TT--EEE-.-S.......-----GGGGX CS
       LRR_4  2 nLevLdLsnNqltdipl.le.klpnLkeLdLsgN.......nlitdldeLk 43
                +L+ L+ snN++   ++ +   +++L++Ld+ +N       n it+ld+Lk
  EFC35271.1  3 QLTCLSVSNNNIGNEGFkFIcEMKQLTYLDVGRNdinskglNHITNLDKLK 53
                699**********877784434*********88977788888888887775 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0053
                S--EEE--SS---E-S-...HHH-TT--EEE-. CS
       LRR_4  2 nLevLdLsnNqltdipl...leklpnLkeLdLs 31
                +L+ L +  N + d  +   ++ +++L+ L+++
  EFC35271.1 51 KLKDLRIYYNSVGD--GakyISEMKQLTNLNVN 81
                68888999899997..43344459999999993 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.071
                 H-TT--EEE-.-S--- CS
       LRR_4  21 klpnLkeLdLsgNnli 36 
                  lp  + L++s+N  i
  EFC35271.1  95 ELPLVTNLNISFN-EI 109
                 3888899999888.44 PP

  == domain 4  score: 14.9 bits;  conditional E-value: 1.1e-05
                 --EEE--SS---E-S-HH..H.-TT--EEE-.-S---- CS
       LRR_4   3 LevLdLsnNqltdiplle..k.lpnLkeLdLsgNnlit 37 
                  ++L++s N +   +l e  + +++L++L++ +N +i+
  EFC35271.1  99 VTNLNISFNEIGNQGL-EhiSrMKQLTHLNIQSN-NID 134
                 589*********6666.34555*********666.465 PP

  == domain 5  score: 20.3 bits;  conditional E-value: 2e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsg 32 
                 ++L++L++++N++ d +   l +l++L++Ld+s 
  EFC35271.1 121 KQLTHLNIQSNNIDDTGVyfLHGLDQLTTLDISK 154
                 58*************99997778*********86 PP

  == domain 6  score: 8.5 bits;  conditional E-value: 0.0011
                 S--EEE--SS---E-S-..HHH-TT--E CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLke 27 
                 +L++Ld+s ++++  +   ++ ++nL++
  EFC35271.1 170 QLTHLDISECCIQYEGVkhISEMKNLTY 197
                 79***********545576445999997 PP

  == domain 7  score: -3.1 bits;  conditional E-value: 4.8
                 SS--EE CS
       LRR_4   1 pnLevL 6  
                 +nL++L
  EFC35271.1 217 KNLIKL 222
                 355554 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.2      0.13   3.2e+02       2      14 ..       4      16 ..       3      24 .. 0.75
   2 !    7.4   0.1    0.0033       8.5       1      23 []      27      49 ..      27      49 .. 0.90
   3 ?   -0.9   0.0       1.7   4.4e+03       1      12 [.      51      62 ..      51      72 .. 0.80
   4 ?    1.2   0.1      0.35   8.9e+02       5      17 ..     102     114 ..      99     120 .. 0.70
   5 !    7.1   0.1     0.004        10       1      17 [.     122     138 ..     122     144 .. 0.75
   6 ?    1.2   0.0      0.35     9e+02       1      12 [.     146     157 ..     146     166 .. 0.79
   7 !    8.7   0.1    0.0012       3.1       1      13 [.     170     189 ..     170     216 .. 0.73

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.13
       LRR_1  2 LrhLdLsnnpllg 14
                L+ L +snn++++
  EFC35271.1  4 LTCLSVSNNNIGN 16
                8899*****9843 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0033
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                +L++Ld+++n + +++ n++ nL
  EFC35271.1 27 QLTYLDVGRNDINSKGLNHITNL 49
                599*********99999999876 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 1.7
       LRR_1  1 nLrhLdLsnnpl 12
                +L+ L + +n+ 
  EFC35271.1 51 KLKDLRIYYNSV 62
                799999999985 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.35
       LRR_1   5 LdLsnnpllglpp 17 
                 L++s n +++ + 
  EFC35271.1 102 LNISFNEIGNQGL 114
                 99**999855444 PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.004
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L+hL++ +n++++ + 
  EFC35271.1 122 QLTHLNIQSNNIDDTGV 138
                 59*****9999976555 PP

  == domain 6  score: 1.2 bits;  conditional E-value: 0.35
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+s  ++
  EFC35271.1 146 QLTTLDISKHII 157
                 599****97665 PP

  == domain 7  score: 8.7 bits;  conditional E-value: 0.0012
       LRR_1   1 nLrhLdLsnnpl.......l 13 
                 +L+hLd+s +++       +
  EFC35271.1 170 QLTHLDISECCIqyegvkhI 189
                 59*********955544440 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.0    0.0019       4.9      63     131 ..       1      68 [.       1      72 [. 0.77
   2 !   12.5   0.1     3e-05     0.076      63     149 ..      72     154 ..      64     163 .. 0.84
   3 !    9.8   0.1    0.0002      0.52      47     125 ..     102     181 ..      95     200 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0019
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkey 131
                 +++l +l+++nn i + + ++   + +l+ l +  n +++   l+ +++l kl+ l +  n+v +  +y
  EFC35271.1   1 MRQLTCLSVSNNNIGNEGFKFICEMKQLTYLDVGRNDINSK-GLNHITNLDKLKDLRIYYNSVGDGAKY 68 
                 67889999999999888877777888888888888888775.468888888888888888888777666 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 3e-05
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldfrk 149
                 +k+l  l +n   i   + ++   lP +++l ++ ne+ + + l+ +  +k+l+ l + +n + +      y ++ l+ql+ ld  k
  EFC35271.1  72 MKQLTNLNVNTACINEKGAKFISELPLVTNLNISFNEIGNQG-LEHISRMKQLTHLNIQSNNIDD---TGVYFLHGLDQLTTLDISK 154
                 788899999999999999999999*********999999865.7999999999999999987755...5677889999999999766 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.0002
       LRR_9  47 idlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 +++s n+i  + l+ +  +k+l  l +++n i  ++  + + l +l++l +++  + e ++ + l ++++l+ l + ++ +
  EFC35271.1 102 LNISFNEIgnQGLEHISRMKQLTHLNIQSNNIDDTGVYFLHGLDQLTTLDISKHIIGEKGT-KLLSEMEQLTHLDISECCI 181
                 56677777334588888899999999999***99999999999999999999999999998.8899999999999888776 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.77     2e+03     103     121 ..      15      33 ..      12      37 .. 0.88
   2 !    5.9   0.0     0.004        10      79     122 ..      42      81 ..      27     113 .. 0.78
   3 ?    2.7   0.0      0.04     1e+02     104     129 ..     111     137 ..     107     156 .. 0.71
   4 ?    2.7   0.0     0.038        98     103     122 ..     158     177 ..     154     179 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.77
     DUF4347 103 geaGeafvekLaqltgadv 121
                 g++G +f+ +++qlt  dv
  EFC35271.1  15 GNEGFKFICEMKQLTYLDV 33 
                 678999*********9988 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.004
     DUF4347  79 elaqwgealsedadillYgCnvAageaGeafvekLaqltgadva 122
                  l+++ ++l++ +d+ +Y  +v+ g    +++++++qlt+ +v 
  EFC35271.1  42 GLNHI-TNLDKLKDLRIYYNSVGDG---AKYISEMKQLTNLNVN 81 
                 45555.6778889999999999876...7999999999999995 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.04
     DUF4347 104 eaGeafvekLaqltgadvaAst.dltG 129
                 ++G + +++++qlt+ ++++++ d tG
  EFC35271.1 111 NQGLEHISRMKQLTHLNIQSNNiDDTG 137
                 678888888888888888776435565 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.038
     DUF4347 103 geaGeafvekLaqltgadva 122
                 ge+G++++++++qlt+ d++
  EFC35271.1 158 GEKGTKLLSEMEQLTHLDIS 177
                 789*************9995 PP

>> RNA_pol_I_TF  RNA polymerase I specific initiation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.15   3.7e+02      15      47 ..      20      52 ..       7      62 .. 0.78
   2 ?    8.5   0.5   0.00051       1.3      25      58 ..     101     134 ..      70     173 .. 0.79
   3 ?    0.9   0.0      0.11   2.7e+02      20      53 ..     168     201 ..     151     214 .. 0.74

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.15
  RNA_pol_I_TF 15 nflikskglevlpdskseirsyktkhienltql 47
                  +f  + k l  l+   ++i+s+  +hi+nl +l
    EFC35271.1 20 KFICEMKQLTYLDVGRNDINSKGLNHITNLDKL 52
                  566677778888888899999999999999887 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00051
  RNA_pol_I_TF  25 vlpdskseirsyktkhienltqllhlnilrrnwk 58 
                    l+ s +ei ++  +hi+ ++ql hlni ++n +
    EFC35271.1 101 NLNISFNEIGNQGLEHISRMKQLTHLNIQSNNID 134
                   445678899999*****************99975 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.11
  RNA_pol_I_TF  20 skglevlpdskseirsyktkhienltqllhlnil 53 
                    + l  l+ s+  i+ +  khi+++++l + ni 
    EFC35271.1 168 MEQLTHLDISECCIQYEGVKHISEMKNLTYPNIC 201
                   45555555555556667899**********9996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       431  (0.0240393); expected 358.6 (0.02)
Passed bias filter:                      238  (0.0132746); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.57
# Mc/sec: 1191.88
//
Query:       EFC35272.1  [L=155]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.038   14.0   4.8       0.12   12.4   3.7    2.1  2  Big_1     Bacterial Ig-like domain (group 1)


Domain annotation for each model (and alignments):
>> Big_1  Bacterial Ig-like domain (group 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0     0.045     8e+02      25      50 ..      11      37 ..       4      40 .. 0.80
   2 ?   12.4   3.7   6.6e-06      0.12      30      62 ..      86     122 ..      76     124 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.045
       Big_1 25 tVtfsvsg.galsassgtTdanGkatv 50
                +V++  +  g+l + +++T   G+++ 
  EFC35272.1 11 QVNWAKPIpGQLYNMTAVTTGGGQVRL 37
                688888888888888888888888765 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 6.6e-06
       Big_1  30 vsg.gals...assgtTdanGkatvtltstkagtvtv 62 
                 +s+  +++   ++++tT +nG++ v+ t+t +g+++v
  EFC35272.1  86 SSSsCTILkveTPQTTTSSNGIIAVNSTNTLPGSKSV 122
                 444333335779**********************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (155 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.55
# Mc/sec: 851.75
//
Query:       EFC35273.1  [L=306]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.2e-54  175.7   1.7    1.4e-05   24.8   0.0   10.1 10  LRR_6           Leucine Rich repeat
    3.6e-27   93.9  20.6    3.9e-07   29.7   0.2    5.0  5  LRR_8           Leucine rich repeat
    2.2e-25   88.3  10.7    5.7e-05   23.4   0.0    6.7  8  LRR_4           Leucine Rich repeats (2 copies)
    2.5e-15   54.7   0.0        9.3    7.2   0.0   10.3 11  LRR_1           Leucine Rich Repeat
    9.7e-05   21.9   0.9       0.21   11.1   0.2    3.3  5  LRR_9           Leucine-rich repeat
    0.00072   20.1   0.3         40    4.9   0.0    4.4  5  Apo-VLDL-II     Apovitellenin I (Apo-VLDL-II)
  ------ inclusion threshold ------
        0.1   12.0   2.6        1.6    8.1   0.1    3.8  3  ArenaCapSnatch  Arenavirus cap snatching domain
       0.11   12.6   0.2       0.25   11.4   0.2    1.6  1  Dynein_heavy    Dynein heavy chain region D6 P-loop domain
       0.28   11.0   7.2        3.1    7.5   0.2    3.2  3  UPF0193         Uncharacterised protein family (UPF0193)
        1.5    8.7   7.8        3.8    7.3   3.0    2.2  2  Beta_helix      Right handed beta helix region


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   6.1e-07    0.0011       4      23 ..      78      97 ..      76      98 .. 0.91
   2 !   15.5   0.0   7.1e-06     0.013       5      24 .]     103     122 ..     100     122 .. 0.92
   3 !   18.0   0.0   1.2e-06    0.0021       5      24 .]     127     146 ..     124     146 .. 0.92
   4 !   16.1   0.0   4.5e-06    0.0081       5      24 .]     151     170 ..     148     170 .. 0.92
   5 !   15.2   0.0     9e-06     0.016       5      22 ..     175     192 ..     172     194 .. 0.91
   6 !   12.5   0.0   6.6e-05      0.12       5      24 .]     199     218 ..     196     218 .. 0.92
   7 !   22.3   0.0   4.8e-08   8.6e-05       5      24 .]     223     242 ..     220     242 .. 0.92
   8 !   18.1   0.0   1.1e-06    0.0019       5      24 .]     247     266 ..     245     266 .. 0.91
   9 !   24.8   0.0   7.8e-09   1.4e-05       5      24 .]     271     290 ..     268     290 .. 0.92
  10 ?    1.5   0.0      0.23   4.1e+02       5      12 ..     295     302 ..     292     302 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 6.1e-07
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                 Lt+Ld+s+N+Ig +G++ +
  EFC35273.1 78 RLTSLDISFNQIGVQGVKFI 97
                59***************977 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 7.1e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s+N+ +DeGa+ ++
  EFC35273.1 103 LTSLDISFNQASDEGAKYIS 122
                 9***************9885 PP

  == domain 3  score: 18.0 bits;  conditional E-value: 1.2e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L +s N IgDeGa+ ++
  EFC35273.1 127 LTSLGISKNLIGDEGAKYIS 146
                 9***************9885 PP

  == domain 4  score: 16.1 bits;  conditional E-value: 4.5e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L+L +N+I DeGa+ ++
  EFC35273.1 151 LTSLNLYYNEICDEGAKYIS 170
                 9***************9885 PP

  == domain 5  score: 15.2 bits;  conditional E-value: 9e-06
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+s+N I+ eG++ 
  EFC35273.1 175 LTSLDISSNLIDVEGVKF 192
                 9***************86 PP

  == domain 6  score: 12.5 bits;  conditional E-value: 6.6e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N+Ig eGa+ ++
  EFC35273.1 199 LTSLNIYYNGIGVEGAKYIS 218
                 9***************9885 PP

  == domain 7  score: 22.3 bits;  conditional E-value: 4.8e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L+++ N+IgDeGa+ ++
  EFC35273.1 223 LTSLNITNNEIGDEGAKYIS 242
                 9***************9885 PP

  == domain 8  score: 18.1 bits;  conditional E-value: 1.1e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +L +s N+IgDeGa+ ++
  EFC35273.1 247 LISLIISRNQIGDEGAKYIC 266
                 66899************998 PP

  == domain 9  score: 24.8 bits;  conditional E-value: 7.8e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++sgN+IgDeGa+ ++
  EFC35273.1 271 LTSLNISGNEIGDEGAKYIS 290
                 9***************9885 PP

  == domain 10  score: 1.5 bits;  conditional E-value: 0.23
       LRR_6   5 LteLdLsg 12 
                 Lt+Ld+s+
  EFC35273.1 295 LTSLDISF 302
                 9*****96 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.2   2.2e-10   3.9e-07       2      61 .]      78     137 ..      77     137 .. 0.98
   2 !   26.9   1.2   1.6e-09   2.9e-06       2      61 .]     126     185 ..     125     185 .. 0.98
   3 !   29.5   0.6   2.5e-10   4.5e-07       2      61 .]     174     233 ..     173     233 .. 0.98
   4 !   28.6   0.2   4.9e-10   8.8e-07       2      61 .]     222     281 ..     221     281 .. 0.98
   5 !   19.1   0.0   4.7e-07   0.00084       2      57 ..     246     301 ..     245     303 .. 0.94

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 2.2e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+s+N++ + + ++ +g+++L++Ld+s N+ +   ++ +s +++L+sL +s N +
  EFC35273.1  78 RLTSLDISFNQIGVQGVKFISGMKQLTSLDISFNQASDEGAKYISEMKQLTSLGISKNLI 137
                 8*********************************************************87 PP

  == domain 2  score: 26.9 bits;  conditional E-value: 1.6e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL +s+N + + + +  + +++L++L+L +N++    ++ +s +++L+sLd+s+N +
  EFC35273.1 126 QLTSLGISKNLIGDEGAKYISEMKQLTSLNLYYNEICDEGAKYISEMEQLTSLDISSNLI 185
                 7*********************************************************87 PP

  == domain 3  score: 29.5 bits;  conditional E-value: 2.5e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+s+N + + + ++ k +++L++L++ +N + +  ++ +s +++L+sL++++N +
  EFC35273.1 174 QLTSLDISSNLIDVEGVKFIKEMKQLTSLNIYYNGIGVEGAKYISEMKQLTSLNITNNEI 233
                 7*********************************************************87 PP

  == domain 4  score: 28.6 bits;  conditional E-value: 4.9e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL+++nN + + + +  + +++L +L +s+N++    ++ +  +++L+sL++sgN +
  EFC35273.1 222 QLTSLNITNNEIGDEGAKYISEMKQLISLIISRNQIGDEGAKYICEMEQLTSLNISGNEI 281
                 7*********************************************************87 PP

  == domain 5  score: 19.1 bits;  conditional E-value: 4.7e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 +L sL++s+N++ + + +    +++L++L++s N++    ++ +s++++L+sLd+s
  EFC35273.1 246 QLISLIISRNQIGDEGAKYICEMEQLTSLNISGNEIGDEGAKYISDMKQLTSLDIS 301
                 57799*************************************************98 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.1   0.00044      0.79      17      36 ..      71      89 ..      49      90 .. 0.76
   2 !   23.4   0.0   3.2e-08   5.7e-05       1      33 [.      77     111 ..      77     116 .. 0.84
   3 !   15.2   0.0   1.2e-05     0.022       1      35 [.     125     160 ..     125     165 .. 0.85
   4 !   18.1   0.1   1.4e-06    0.0026       2      33 ..     174     207 ..     173     213 .. 0.82
   5 !   17.1   0.5   3.1e-06    0.0055       1      38 [.     197     235 ..     197     239 .. 0.83
   6 !   14.4   0.3   2.1e-05     0.038       1      38 [.     221     259 ..     221     262 .. 0.87
   7 !   19.3   0.0     6e-07    0.0011       1      37 [.     245     282 ..     245     287 .. 0.87
   8 !   17.0   0.1   3.3e-06     0.006       2      32 ..     270     302 ..     269     305 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00044
                S-HHH-TT--EEE-.-S--- CS
       LRR_4 17 plleklpnLkeLdLsgNnli 36
                 +++ ++ L++Ld+s+N +i
  EFC35273.1 71 KFISDMKRLTSLDISFN-QI 89
                23335*********888.76 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 3.2e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 ++L++Ld+s Nq+   +   ++++++L++Ld+s+N
  EFC35273.1  77 KRLTSLDISFNQIGVQGVkfISGMKQLTSLDISFN 111
                 68**********99777784556*********998 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 1.2e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 ++L++L +s N + d +   ++ +++L++L+L  N  
  EFC35273.1 125 KQLTSLGISKNLIGDEGAkyISEMKQLTSLNLYYN-E 160
                 58*************99986445*********777.4 PP

  == domain 4  score: 18.1 bits;  conditional E-value: 1.4e-06
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgN 33 
                 +L++Ld+s+N +   +  + k +++L++L++  N
  EFC35273.1 174 QLTSLDISSNLIDVEGVkFIKeMKQLTSLNIYYN 207
                 79*******8888555587777*********777 PP

  == domain 5  score: 17.1 bits;  conditional E-value: 3.1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++  N +   +   ++ +++L++L++  Nn i+d
  EFC35273.1 197 KQLTSLNIYYNGIGVEGAkyISEMKQLTSLNI-TNNEIGD 235
                 58************766676445*********.7778876 PP

  == domain 6  score: 14.4 bits;  conditional E-value: 2.1e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++ nN + d +   ++ +++L +L +s+N +i+d
  EFC35273.1 221 KQLTSLNITNNEIGDEGAkyISEMKQLISLIISRN-QIGD 259
                 58*************99986445*******99999.8876 PP

  == domain 7  score: 19.3 bits;  conditional E-value: 6e-07
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 ++L++L +s Nq+ d +    +e + +L++L++sgN  i+
  EFC35273.1 245 KQLISLIISRNQIGDEGAkyiCE-MEQLTSLNISGN-EIG 282
                 589************99987555.************.554 PP

  == domain 8  score: 17.0 bits;  conditional E-value: 3.3e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsg 32 
                 +L++L++s+N + d +   ++ +++L++Ld+s+
  EFC35273.1 270 QLTSLNISGNEIGDEGAkyISDMKQLTSLDISF 302
                 79************99986556*********75 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1       1.5   2.7e+03       7      15 ..       9      17 ..       2      22 .. 0.77
   2 ?    5.6   0.0     0.019        33       1      13 [.      78      90 ..      78     100 .. 0.79
   3 ?    3.3   0.0      0.11   1.9e+02       1      11 [.     102     112 ..     102     124 .. 0.82
   4 ?   -1.0   0.0       2.6   4.7e+03       2      20 ..     127     145 ..     126     148 .. 0.77
   5 ?    4.2   0.0     0.051        92       1      20 [.     150     169 ..     150     172 .. 0.80
   6 ?    4.8   0.0     0.033        60       1      13 [.     174     186 ..     174     196 .. 0.78
   7 ?    2.8   0.0      0.15   2.6e+02       1      17 [.     198     214 ..     198     220 .. 0.76
   8 !    7.0   0.0    0.0062        11       1      20 [.     222     241 ..     222     244 .. 0.82
   9 ?    2.2   0.0      0.24   4.2e+02       2      21 ..     247     266 ..     246     268 .. 0.82
  10 !    7.2   0.0    0.0052       9.3       1      19 [.     270     288 ..     270     292 .. 0.82
  11 ?    1.3   0.0      0.48   8.6e+02       1      11 [.     294     304 ..     294     305 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 1.5
       LRR_1  7 Lsnnpllgl 15
                L+n++l+++
  EFC35273.1  9 LNNCSLISK 17
                899999755 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.019
       LRR_1  1 nLrhLdLsnnpll 13
                +L++Ld+s n+++
  EFC35273.1 78 RLTSLDISFNQIG 90
                69********984 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++Ld+s n+
  EFC35273.1 102 QLTSLDISFNQ 112
                 599******97 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 2.6
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L++L +s n +++ ++ ++
  EFC35273.1 127 LTSLGISKNLIGDEGAKYI 145
                 8999999999887776665 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.051
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L+L +n + + ++ ++
  EFC35273.1 150 QLTSLNLYYNEICDEGAKYI 169
                 599*******9987776665 PP

  == domain 6  score: 4.8 bits;  conditional E-value: 0.033
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+s+n ++
  EFC35273.1 174 QLTSLDISSNLID 186
                 599*******885 PP

  == domain 7  score: 2.8 bits;  conditional E-value: 0.15
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++ +n ++  ++
  EFC35273.1 198 QLTSLNIYYNGIGVEGA 214
                 599*******9866655 PP

  == domain 8  score: 7.0 bits;  conditional E-value: 0.0062
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L+++nn +++ ++ ++
  EFC35273.1 222 QLTSLNITNNEIGDEGAKYI 241
                 599********988877766 PP

  == domain 9  score: 2.2 bits;  conditional E-value: 0.24
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L +L +s+n++++ ++ +++
  EFC35273.1 247 LISLIISRNQIGDEGAKYIC 266
                 889*******9988877765 PP

  == domain 10  score: 7.2 bits;  conditional E-value: 0.0052
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L++s+n +++ ++ +
  EFC35273.1 270 QLTSLNISGNEIGDEGAKY 288
                 599********98877665 PP

  == domain 11  score: 1.3 bits;  conditional E-value: 0.48
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++Ld+s ++
  EFC35273.1 294 QLTSLDISFQS 304
                 599****9876 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.1     0.017        31      55     126 ..      68     138 ..      11     156 .. 0.78
   2 !    6.3   0.0    0.0033         6      48     128 ..      83     164 ..      74     180 .. 0.73
   3 ?    4.7   0.0     0.011        19      63     125 ..     148     209 ..     140     218 .. 0.80
   4 !   11.1   0.2   0.00012      0.21      41     127 ..     172     259 ..     168     276 .. 0.73
   5 !    9.9   0.0   0.00028       0.5      62     127 ..     219     283 ..     198     301 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.017
       LRR_9  55 rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                  kl  +  +krl +l ++ n+i   + ++   + +l++l ++ n+  + +  + + ++k+l++l + kn + 
  EFC35273.1  68 EKLKFISDMKRLTSLDISFNQIGVQGVKFISGMKQLTSLDISFNQASDEGA-KYISEMKQLTSLGISKNLIG 138
                 566666678888888888888888888888888888888888888777666.77888888888888777665 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0033
       LRR_9  48 dlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 d+s n+i  + +  +  +k+l +l ++ n+    + +    + +l++l +++n + + +  + + ++k+l++l l  n ++++
  EFC35273.1  83 DISFNQIgvQGVKFISGMKQLTSLDISFNQASDEGAKYISEMKQLTSLGISKNLIGDEGA-KYISEMKQLTSLNLYYNEICDE 164
                 555555411445555567777788888888888777777888889999999999999888.8999999999999999999875 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.011
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 +k+l +l l  n i+  + +    + +l++l +++n + ++  ++ + ++k+l++l +  n +
  EFC35273.1 148 MKQLTSLNLYYNEICDEGAKYISEMEQLTSLDISSNLI-DVEGVKFIKEMKQLTSLNIYYNGI 209
                 77888888889999988888888888888888887766.677889999999999999887765 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00012
       LRR_9  41 ldqfdtidlsdndirkldgfPllkrlktl...llnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 ++q+ ++d+s n i +++g+ ++k +k l    +  n i   + +    + +l++l +tnne+ + +  + + ++k+l +l + +n + +
  EFC35273.1 172 MEQLTSLDISSNLI-DVEGVKFIKEMKQLtslNIYYNGIGVEGAKYISEMKQLTSLNITNNEIGDEGA-KYISEMKQLISLIISRNQIGD 259
                 57888999999855.67777777666655100555677766666666677788899999999999887.899999999999999888764 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00028
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                  +k+l +l + nn i   + +    + +l +l+++ n++ + +  + + ++++l++l +  n + +
  EFC35273.1 219 EMKQLTSLNITNNEIGDEGAKYISEMKQLISLIISRNQIGDEGA-KYICEMEQLTSLNISGNEIGD 283
                 47889999999999999999999999999999*******99888.899999999999999888765 PP

>> Apo-VLDL-II  Apovitellenin I (Apo-VLDL-II)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.1     0.032        58      47      71 ..      16      41 ..       8      48 .. 0.72
   2 ?    4.9   0.0     0.022        40      25      67 ..     109     151 ..     106     161 .. 0.87
   3 ?   -0.2   0.0      0.85   1.5e+03      16      51 ..     163     198 ..     157     224 .. 0.70
   4 ?    2.3   0.0      0.15   2.6e+02      29      69 ..     209     249 ..     203     254 .. 0.85
   5 ?    4.5   0.0     0.028        51      27      68 ..     231     272 ..     214     279 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.032
  Apo-VLDL-II 47 letrniliketakvsilfeq.lveki 71
                 ++    +ike +k+ i+f q + ek 
   EFC35273.1 16 SKQFFNVIKERSKLVIQFKQkFTEKR 41
                 5555569***********97245665 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.022
  Apo-VLDL-II  25 avnkvsPkvaqflvdivqipvvletrniliketakvsilfeql 67 
                  ++n+ s   a+++ ++ q + +  ++n++  e ak    + ql
   EFC35273.1 109 SFNQASDEGAKYISEMKQLTSLGISKNLIGDEGAKYISEMKQL 151
                  79*****************************999976666665 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.85
  Apo-VLDL-II  16 daiaayvyeavnkvsPkvaqflvdivqipvvletrn 51 
                  d  a y+ e     s  ++  l+d+  + ++ e ++
   EFC35273.1 163 DEGAKYISEMEQLTSLDISSNLIDVEGVKFIKEMKQ 198
                  444566666666666666666666666666666555 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.15
  Apo-VLDL-II  29 vsPkvaqflvdivqipvvletrniliketakvsilfeqlve 69 
                  +    a+++ ++ q + +  t n +  e ak    + ql+ 
   EFC35273.1 209 IGVEGAKYISEMKQLTSLNITNNEIGDEGAKYISEMKQLIS 249
                  5556789***********************98888888886 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.028
  Apo-VLDL-II  27 nkvsPkvaqflvdivqipvvletrniliketakvsilfeqlv 68 
                  n +    a+++ ++ q   +  +rn +  e ak    +eql 
   EFC35273.1 231 NEIGDEGAKYISEMKQLISLIISRNQIGDEGAKYICEMEQLT 272
                  566677789999999999999999999999999999999985 PP

>> ArenaCapSnatch  Arenavirus cap snatching domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.1   0.00091       1.6      99     144 ..      55     100 ..      48     109 .. 0.82
   2 ?    0.7   0.1      0.18   3.1e+02      56      56 ..     210     210 ..     142     276 .. 0.67
   3 ?    0.8   0.1      0.16   2.8e+02     114     123 ..     286     295 ..     206     305 .. 0.60

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00091
                     EEEEEEE-SSHHHHHH.HHHHHHHHHHTTHHHHHHTT-EEEEEEEEE CS
  ArenaCapSnatch  99 illecfvrsspaefek.kyiedlkkleqlkedlksagitlvpvvdGr 144
                     i l++f r   ++fek k+i+d+k+l++l   +++ g++ v  + G 
      EFC35273.1  55 INLKVF-RYLLDSFEKlKFISDMKRLTSLDISFNQIGVQGVKFISGM 100
                     555555.66678999889**************999999999999886 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.18
                     H CS
  ArenaCapSnatch  56 e 56 
                      
      EFC35273.1 210 G 210
                     1 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.16
                     HHHHHHHHHH CS
  ArenaCapSnatch 114 kkyiedlkkl 123
                      kyi+d+k+l
      EFC35273.1 286 AKYISDMKQL 295
                     3555555555 PP

>> Dynein_heavy  Dynein heavy chain region D6 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2   0.00014      0.25      53      99 ..       2      53 ..       1      69 [. 0.76

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00014
                  HHT-EEEEE-GGG-.CCCHHHHHHH...........HHTT-EEEEEEES-TT CS
  Dynein_heavy 53 kegsWvlLqNchla.pswlkeLekileel....eeklhssfRlwltsepspk 99
                   ++sW +L+Nc l+ +++ + +++  + +    ++ ++++  l++ s+  ++
    EFC35273.1  2 LDDSWFILNNCSLIsKQFFNVIKERSKLViqfkQKFTEKRVELFMKSQFRNR 53
                  5799*********989999988888542244556666778899998887776 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.2    0.0017       3.1     171     207 ..     141     177 ..     135     184 .. 0.91
   2 ?    5.9   0.1    0.0055       9.9     171     209 ..     189     227 ..     177     234 .. 0.89
   3 ?   -0.4   0.2      0.46   8.2e+02     170     207 ..     236     273 ..     230     281 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0017
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                  +++++eM++L   + Y ++I +e ++ + e+e+l +
  EFC35273.1 141 GAKYISEMKQLTSLNLYYNEICDEGAKYISEMEQLTS 177
                 5799*****************************9975 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0055
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklrelealdkkr 209
                  ++F++eM++L   + Y + I  e ++ + e+++l + +
  EFC35273.1 189 GVKFIKEMKQLTSLNIYYNGIGVEGAKYISEMKQLTSLN 227
                 579*******************************98765 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.46
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 e +++++eM++L      r+ I +e ++ + e+e+l +
  EFC35273.1 236 EGAKYISEMKQLISLIISRNQIGDEGAKYICEMEQLTS 273
                 55788889999988888999999999999999999876 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   3.5     0.039        69      18     133 ..      86     232 ..      73     233 .. 0.65
   2 ?    7.3   3.0    0.0021       3.8      20      91 ..     203     285 ..     188     301 .. 0.60

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.039
                 EES-SS-SEEE-SSS-.....EEES-EEES-SS-SEEE-TT....-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEE CS
  Beta_helix  18 isnsggyGiylrgssn....vvienneiannsgsGiyilgs....snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntie 106
                 ++ +g +G+++ ++++      i+ n  ++ +   i+        +   is+n i d +  +   +++     +++nei d g   i+ + + ++++i+
  EFC35273.1  86 FNQIGVQGVKFISGMKqltsLDISFNQASDEGAKYIS---EmkqlTSLGISKNLIGDEGaKYISEMKQLTSLNLYYNEICDEGAKYISEMeQLTSLDIS 181
                 4455778888888888433333333333333344444...3444899999*****99995555556688888899999999988777444378889999 PP

                 S-EEESTT................--SEE---TT........---EEES-E CS
  Beta_helix 107 nNiidnna................gsGividdss........snvtvtnNt 133
                  N id  +                 +Gi ++  +        +++++tnN 
  EFC35273.1 182 SNLIDVEGvkfikemkqltslniyYNGIGVEGAKyisemkqlTSLNITNNE 232
                 999987776666666666666666566666555555555556666666665 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0021
                 S-SS-SEEE-SSS-..........EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-S CS
  Beta_helix  20 nsggyGiylrgssn.........vvienneiannsgsGiyilgs.snntisnntisdnn.gggialfgasnnlienneitdng 91 
                 n++++Gi ++g++            i+nnei + +   i+  ++    +is+n+i d +  + + +++     i++nei d g
  EFC35273.1 203 NIYYNGIGVEGAKYisemkqltsLNITNNEIGDEGAKYISEMKQlISLIISRNQIGDEGaKYICEMEQLTSLNISGNEIGDEG 285
                 44555555555555555556665566666666655555555555566666666666666455555556666666666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (306 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       612  (0.0341346); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.70u 0.36s 00:00:01.06 Elapsed: 00:00:00.55
# Mc/sec: 1672.34
//
Query:       EFC35274.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.079   12.8   0.2       0.14   12.0   0.2    1.5  1  TIR       TIR domain


Domain annotation for each model (and alignments):
>> TIR  TIR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.2   7.8e-06      0.14      65     100 ..     124     156 ..      83     162 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 7.8e-06
                 E-TTHHHHCCCCHHHHHHHCHHH-CTSTCEEEEECS CS
         TIR  65 lSknyasskwcleElekilecalvekgqkvilifye 100
                 lS ++++sk c +E+ ++l+c+       +i+i ++
  EFC35274.1 124 LSAEMINSKACFDEFMIALYCKA---VVGIIPIALC 156
                 89********************9...6778888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       398  (0.0221987); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.54
# Mc/sec: 978.81
//
Query:       EFC35275.1  [L=295]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-28   99.0   0.0    4.4e-28   98.1   0.0    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    5.9e-15   55.4   0.1    1.1e-14   54.5   0.1    1.5  1  PAS_9          PAS domain
    1.1e-08   35.0   0.0    2.3e-08   34.0   0.0    1.6  1  PAS            PAS fold
     0.0076   16.8   0.0      0.014   15.9   0.0    1.5  1  PAS_10         PAS domain
  ------ inclusion threshold ------
      0.033   13.6   0.1      0.053   12.9   0.1    1.3  1  HNOBA          Heme NO binding associated
      0.089   12.8   0.0        0.2   11.7   0.0    1.5  1  PAS_8          PAS domain
       0.12   13.1   0.0       0.27   11.9   0.0    1.6  1  PAS_2          PAS fold
       0.44   10.1   1.8        3.5    7.3   0.2    2.6  2  Sgf11_N        SAGA-associated factor 11 N-terminal domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   98.1   0.0     2e-31   4.4e-28       3     113 ..     183     295 .]     181     295 .] 0.97

  Alignments for each domain:
  == domain 1  score: 98.1 bits;  conditional E-value: 2e-31
  Guanylate_cyc   3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevaves. 96 
                    ae+++++t +F+d+vgft++ss ++p e+v +L ++++ fd+l+d + ++k+ktiGday +v gl+ +++ +h ++ +++a+d ++ +++ ++e+ 
     EFC35275.1 183 AERFSDITCFFSDMVGFTKMSSGMNPSELVLMLSSIVNGFDDLTDVYSLEKIKTIGDAYFCVGGLHnNPQSDHPERTLRFAIDTFQVIRNYNIEHp 278
                    68999*************************************************************88999*****************99998888 PP

  Guanylate_cyc  97 keglkvrvGihtGpvva 113
                    +++l++rvGi+tG+vva
     EFC35275.1 279 QNQLNIRVGINTGSVVA 295
                    ***************96 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.5   0.1   4.9e-18   1.1e-14       2     103 ..      31     143 ..      30     144 .. 0.88

  Alignments for each domain:
  == domain 1  score: 54.5 bits;  conditional E-value: 4.9e-18
       PAS_9   2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk........kerevevvlirkngetfwvlltaspv.....kd 87 
                 dg l+ n++g+i+ +Ne a +++G s  +v+g++++ lf  ++e+n  l+++++++ +        +    e++++rkn ++f++ +t++       k 
  EFC35275.1  31 DGALLANENGEIIVFNEPAQNMFGKSISDVIGTHFSKLF--SDESNPALEKIIKMIGElkneeaakHGDVIELECVRKNLTKFPAVVTIFVSqisgmKG 127
                 6888999********************************..99999999999999999999***********************998884444244365 PP

       PAS_9  88 ddgelvgiivilrDit 103
                 ++   + i +i+rDit
  EFC35275.1 128 NSSSSMVISCIMRDIT 143
                 566666688******9 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.0   0.0     1e-11   2.3e-08       3      92 ..      22     104 ..      20     122 .. 0.81

  Alignments for each domain:
  == domain 1  score: 34.0 bits;  conditional E-value: 1e-11
                 HHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEECTTSSEEEEEEE CS
         PAS   3 lraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfklrdgrpihlevr 92 
                 +++++ s++d+ ++ +e+g+i+ +N+ a+ ++G s ++v+g +++ l++ e     + +le+ ++   e +++e    + +g +i+le+ 
  EFC35275.1  22 YKEFITSMIDGALLANENGEIIVFNEPAQNMFGKSISDVIGTHFSKLFSDE----SNPALEKIIKMIGELKNEEA--AK-HGDVIELECV 104
                 788999******************************************998....66677666666666666555..33.6666666655 PP

>> PAS_10  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   6.4e-06     0.014       4      72 ..      25      94 ..      22     108 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 6.4e-06
      PAS_10  4 lLnstpieltflDdnlqirrFtpaa.kklfklipadvGrpladihpkkavknveeviealrtgekdevev 72
                +++s+  + + +++n +i+ F++ a +++ k i++ +G + +++ ++++ + +e++i+ + + +++e  +
  EFC35275.1 25 FITSMIDGALLANENGEIIVFNEPAqNMFGKSISDVIGTHFSKLFSDESNPALEKIIKMIGELKNEEAAK 94
                7888999999************9651688899*************************9988887776654 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   2.4e-05     0.053     193     221 .]     147     175 ..     128     175 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.4e-05
       HNOBA 193 esmkeleeekkrtdeLLysmiPkevAerL 221
                 ++++ l eekk +++LL +++P  vA++L
  EFC35275.1 147 KQNSLLAEEKKNSENLLRNILPDAVASKL 175
                 567889********************987 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   9.1e-05       0.2       3      45 ..      22      65 ..      21      87 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 9.1e-05
       PAS_8  3 lralfesspdgiavvd.lgdrivdvNqaalellGys.adlkgell 45
                ++ ++ s+ dg ++++ +g+ i+  N+ a+ ++G s  d++g  +
  EFC35275.1 22 YKEFITSMIDGALLANeNGE-IIVFNEPAQNMFGKSiSDVIGTHF 65
                677899999****9*97888.*************77666666444 PP

>> PAS_2  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00012      0.27      20      68 ..      36      82 ..      31     102 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00012
                EEETTTTEEEEEETTHHHHCSS-CCCCTTTCCCCCSECTTHHHHCCHS- CS
       PAS_2 20 avdekslrvlqvSeNaaemLglteekllgtdlralltassaalLekals 68
                a  +++ +++ + e a++m g +  + +gt++++l++++s  +Lek ++
  EFC35275.1 36 A--NENGEIIVFNEPAQNMFGKSISDVIGTHFSKLFSDESNPALEKIIK 82
                3..5678899999********************************9875 PP

>> Sgf11_N  SAGA-associated factor 11 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.2    0.0016       3.5       1      19 [.      12      30 ..      12      32 .. 0.93
   2 ?    1.2   0.1      0.12   2.7e+02      15      25 ..     135     145 ..     134     153 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0016
                HBHHHHHHHHHHHHHHHHH CS
     Sgf11_N  1 eTidSvSegIynNLlTsmI 19
                eT  S+S++ y   +TsmI
  EFC35275.1 12 ETNSSTSQDSYKEFITSMI 30
                6889**************9 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.12
                 HHHHHHHHHHH CS
     Sgf11_N  15 lTsmIQDIVsr 25 
                 ++++  DI+s 
  EFC35275.1 135 ISCIMRDITSE 145
                 99******995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 1733.99
//
Query:       EFC35276.1  [L=449]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (449 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3679  (0.205198); expected 358.6 (0.02)
Passed bias filter:                      978  (0.0545485); expected 358.6 (0.02)
Passed Vit filter:                       869  (0.048469); expected 17.9 (0.001)
Passed Fwd filter:                       254  (0.014167); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 5.97u 0.47s 00:00:06.44 Elapsed: 00:00:01.17
# Mc/sec: 1161.60
//
Query:       EFC35277.1  [L=431]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.5e-23   82.7   0.1    4.4e-23   81.9   0.1    1.4  1  HATPase_c     Histidine kinase-, DNA gyrase B-, and HSP90-lik
    1.4e-15   57.5   0.1    3.5e-15   56.1   0.1    1.8  1  Response_reg  Response regulator receiver domain
    3.2e-10   39.9   0.4    3.2e-10   39.9   0.4    2.3  3  HisKA         His Kinase A (phospho-acceptor) domain
    7.6e-06   25.8   1.9    0.00026   20.8   0.1    2.7  2  HATPase_c_5   GHKL domain
    0.00014   21.7   0.0    0.00028   20.7   0.0    1.6  1  HATPase_c_3   Histidine kinase-, DNA gyrase B-, and HSP90-lik


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.9   0.1   1.2e-26   4.4e-23       3     111 ..     178     296 ..     176     297 .. 0.88

  Alignments for each domain:
  == domain 1  score: 81.9 bits;  conditional E-value: 1.2e-26
                 HHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE....EE.....TEEEEEEEESSSSSTTHHHTGTCSTTCH.HCSTCHTSTSSSHHHHHHHHHHHHTTTE CS
   HATPase_c   3 ekrLrqiisnlvdNavkfatkageieveika....se.....ddlvisveDnGiGipkedlkklfekfsq.ddstkrggggtGlGlsivkklvelmgGe 91 
                 ++ L+qi+snl++Navk+++k++++e+e k     +e      +++++++D G+Gip++++k++fe+f q  + +++    +GlGl+ v +++++m+G+
  EFC35277.1 178 PSSLHQILSNLLTNAVKASSKNNTVELEAKIietiQEesaefARVEFKIKDHGCGIPESNIKEIFEPFIQlHNVNESHVPSSGLGLTTVLQFIKQMDGT 276
                 678**************97788877766665655511466799***************************9888888899***********8888**** PP

                 EEEEEETTTEEEEEEEEESS CS
   HATPase_c  92 iwvesepgrGttftftlple 111
                 i vese ++G+tf++tlp++
  EFC35277.1 277 IDVESELEKGSTFIVTLPFK 296
                 *****************986 PP

>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.1   0.1   9.7e-19   3.5e-15       1      82 [.     347     429 ..     347     431 .] 0.96

  Alignments for each domain:
  == domain 1  score: 56.1 bits;  conditional E-value: 9.7e-19
                   EEEESSSHHHHHHHHHHHH.HTTEEEEEEESSHHHHHHHHHHHHESEEEEESSCSSSEHHHHHHHHHHCT.TTSEEEEEESSTS CS
  Response_reg   1 vlivdDdplvrellrqlle.eegyeevaeaedgkealellkeekvdlillDinmpgmdGlellkeireed.pelpviiltahse 82 
                   +++++D+ ++r+++ +l+e   gy + + ++dgke++++++ ++  l+++D+nmp+mdG+e++ke+++   +++++iilt++s+
    EFC35277.1 347 IILAEDNAINRKVILKLIEsITGY-TADFVSDGKELVKNFDIRRHRLVITDLNMPNMDGIEAAKELKRLYgNSVKIIILTGNSA 429
                   799****************78***.*****************************************9998899*******9876 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.9   0.4   8.8e-14   3.2e-10       1      65 [.      60     123 ..      60     125 .. 0.95
   2 ?   -2.3   0.0       1.3   4.6e+03      35      47 ..     203     215 ..     173     222 .. 0.55
   3 ?   -3.2   0.0       2.5   8.8e+03      21      47 ..     325     351 ..     323     367 .. 0.57

  Alignments for each domain:
  == domain 1  score: 39.9 bits;  conditional E-value: 8.8e-14
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHC..T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHH CS
       HisKA   1 slgrflagvaHELrtPLsailgnaeaLkregklteelkeyletiesearrldhlvedlLdlsrie 65 
                 s++ fl++++HE+r PL + lg +e+Lk++ + ++++ ++++ i+s+ + l+ l+e++L+l +ie
  EFC35277.1  60 SKSTFLSHISHEFRCPLLSSLGSLELLKET-NMSDKQNRLVDMIISSNNILLMLIEEVLQLMKIE 123
                 7999***********************997.67799999***********************998 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.3
                 SSCHHHHHHHHHH CS
       HisKA  35 eelkeyletiese 47 
                 e  ++ +eti++e
  EFC35277.1 203 ELEAKIIETIQEE 215
                 2233356666655 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.5
                 HHHHHHHHC..T-HSSCHHHHHHHHHH CS
       HisKA  21 lgnaeaLkregklteelkeyletiese 47 
                 l n++ +++e ++t + + y ++i  e
  EFC35277.1 325 LSNVHEMSEESAATNSPEVYSKIILAE 351
                 667777766544455555555555544 PP

>> HATPase_c_5  GHKL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.2     0.018        65      27      90 ..      95     163 ..      84     173 .. 0.62
   2 !   20.8   0.1   7.3e-08   0.00026       4      90 ..     179     282 ..     176     294 .. 0.65

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.018
  HATPase_c_5  27 ekrfIrltvrekkksliisieNsyeg......ekkklesskskkeehGiGlksireivkkykgnlsieae 90 
                  ++r +++ ++++ + l++ ie   +       +k+  +++  k+ + G  lks++ +++ y++++s++ e
   EFC35277.1  95 QNRLVDMIISSN-NILLMLIEEVLQLmkiefnSKNDKRDEYLKTFNLGECLKSLKDVISGYSNHFSVKLE 163
                  566666655543.4444455555444222222112223344556788999*************9998876 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 7.3e-08
  HATPase_c_5   4 ldlcvilgnlLdNAieacsk.............iee.ekrfIrltvrekkksliisieNsyegek..kkle.sskskkeehGiGlksireivkkykgn 84 
                    l  il+nlL NA+ a+sk             i+e + +f r++++ k++   i  +N  e  +   +l+  ++s+    G+Gl+++ + +k+ +g+
   EFC35277.1 179 SSLHQILSNLLTNAVKASSKnntveleakiietIQEeSAEFARVEFKIKDHGCGIPESNIKEIFEpfIQLHnVNESHVPSSGLGLTTVLQFIKQMDGT 276
                  56889**************96655544444444333244444444444444444444444433223422332445677899***************** PP

  HATPase_c_5  85 lsieae 90 
                  +++e e
   EFC35277.1 277 IDVESE 282
                  999876 PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0   7.9e-08   0.00028       4      86 ..     182     271 ..     179     313 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 7.9e-08
  HATPase_c_3   4 ekAlaelvdNsldAdaenvkievn..........knrgkt....geivieDdGkGmseeelknalr.latsskeakrkstslGkkGiGlklAslslgk 86 
                  ++ l  l+ N++ A+++n ++e++               +     e++i+D G G++e+++k+ ++ + + ++    ++  + + G+G  + +l++ k
   EFC35277.1 182 HQILSNLLTNAVKASSKNNTVELEakiietiqeeS----AefarVEFKIKDHGCGIPESNIKEIFEpFIQLHNV---NESHVPSSGLG-LTTVLQFIK 271
                  667889************66666644665553322....135559******************99834455555...45566666777.455555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (431 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       954  (0.0532099); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2507.84
//
Query:       EFC35278.1  [L=202]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (202 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       661  (0.0368676); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.35u 0.23s 00:00:00.57 Elapsed: 00:00:00.37
# Mc/sec: 1647.07
//
Query:       EFC35279.1  [L=318]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.6e-24   84.0   0.8    4.7e-06   26.4   0.0    5.7  5  NHL             NHL repeat
     0.0084   16.2   0.2         20    5.4   0.0    4.1  5  Str_synth       Strictosidine synthase
  ------ inclusion threshold ------
      0.033   14.5   0.2         48    4.4   0.0    3.7  3  Linker_histone  linker histone H1 and H5 family
       0.14   12.4   1.9        2.8    8.2   0.1    3.3  3  Arylesterase    Arylesterase


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.0   1.1e-09   4.7e-06       1      27 [.      52      78 ..      52      79 .. 0.95
   2 !   11.5   0.0   5.3e-05      0.24       4      27 ..     111     134 ..     110     135 .. 0.91
   3 !   13.2   0.0   1.6e-05     0.071       6      27 ..     169     190 ..     165     191 .. 0.91
   4 !   15.0   0.0   4.2e-06     0.019       8      26 ..     228     246 ..     227     247 .. 0.93
   5 !   11.2   0.1   6.5e-05      0.29       3      27 ..     281     305 ..     280     306 .. 0.93

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 1.1e-09
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +n P+++a++s G++y+aD  +hr+++
  EFC35279.1 52 LNGPSSTAINSLGEVYIADKSHHRIRK 78
                799**********************86 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 5.3e-05
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P G+ +ds + +y +Ds nhr+++
  EFC35279.1 111 PYGIGIDSKDLVYFSDSSNHRIRK 134
                 56999*****************97 PP

  == domain 3  score: 13.2 bits;  conditional E-value: 1.6e-05
                 EEEEETTTEEEEEECCCTEEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvqv 27 
                 G+++++n+d++ aD +n+r+++
  EFC35279.1 169 GLTISPNDDVIFADVNNNRIRK 190
                 9*******************97 PP

  == domain 4  score: 15.0 bits;  conditional E-value: 4.2e-06
                 EEETTTEEEEEECCCTEEE CS
         NHL   8 avdsnGdiyVaDsenhrvq 26 
                 av+++G ++++Ds+n+r++
  EFC35279.1 228 AVTPSGKLIISDSNNNRIR 246
                 788**************96 PP

  == domain 5  score: 11.2 bits;  conditional E-value: 6.5e-05
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                  P+Gv+v +n+++y  Ds n+r+++
  EFC35279.1 281 TPAGVSVATNNEVYFVDSLNNRIRK 305
                 6*********************987 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.28   1.3e+03       6      20 ..      61      74 ..      57      83 .. 0.72
   2 !    5.4   0.0    0.0046        20       5      20 ..     116     130 ..     113     139 .. 0.77
   3 ?    4.1   0.0     0.011        50      55      83 ..     163     190 ..     160     195 .. 0.84
   4 ?   -2.6   0.0       1.4   6.3e+03      62      73 ..     227     238 ..     220     248 .. 0.53
   5 ?   -0.1   0.0      0.22     1e+03      60      79 ..     283     301 ..     276     311 .. 0.54

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.28
   Str_synth  6 deetgvlyftdsSsk 20
                ++  g++y+ d S++
  EFC35279.1 61 NSL-GEVYIADKSHH 74
                444.99*****9863 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0046
   Str_synth   5 vdeetgvlyftdsSsk 20 
                 +d++ + +yf+dsS++
  EFC35279.1 116 IDSK-DLVYFSDSSNH 130
                 6777.*******9964 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.011
   Str_synth  55 kLyfanGialsedgsfvlvcetamkrisr 83 
                 k+y + G+++s++++ v+++++  +ri +
  EFC35279.1 163 KIYLPFGLTISPNDD-VIFADVNNNRIRK 190
                 6788999****9976.899***9999877 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 1.4
   Str_synth  62 ialsedgsfvlv 73 
                 +a+++ g+ +++
  EFC35279.1 227 CAVTPSGKLIIS 238
                 555555544332 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 0.22
   Str_synth  60 nGialsedgsfvlvcetamk 79 
                 +G++++ +++ v +++   +
  EFC35279.1 283 AGVSVATNNE-VYFVDSLNN 301
                 5555555443.334444444 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.1     0.026   1.1e+02      48      69 ..      74      95 ..      41      96 .. 0.90
   2 ?    4.4   0.0     0.011        48      44      69 ..     126     151 ..     114     155 .. 0.82
   3 ?    2.2   0.0     0.053   2.4e+02      41      64 ..     294     317 ..     281     318 .] 0.80

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.026
  Linker_histone 48 kalkkgvekgelvqpkgkGasG 69
                    + ++k  ++g++v + g+G++G
      EFC35279.1 74 HRIRKVYNNGTIVTIAGTGIAG 95
                    5799999************998 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.011
  Linker_histone  44 sllkkalkkgvekgelvqpkgkGasG 69 
                        ++ ++k +++g++v + g G +G
      EFC35279.1 126 DSSNHRIRKILSNGTIVTIAGIGSNG 151
                     556899**************977766 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.053
  Linker_histone  41 kfksllkkalkkgvekgelvqpkg 64 
                      f   l++ ++k +++g+++ + g
      EFC35279.1 294 YFVDSLNNRIRKILSNGTIITVAG 317
                     55667999**********999985 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.1   0.00062       2.8      31      78 ..      86     132 ..      65     136 .. 0.85
   2 ?    0.0   0.0      0.22   9.8e+02      51      77 ..     162     187 ..     152     194 .. 0.79
   3 ?    0.7   0.1      0.14   6.3e+02      42      78 ..     268     303 ..     266     307 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00062
  Arylesterase  31 lqlawtavvYyspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   +  a t++  y+++ +    ++l s+ GI+id+++  +y +d+ ++ i
    EFC35279.1  86 VTIAGTGIAGYNGDGIDATTAQLFSPYGIGIDSKD-LVYFSDSSNHRI 132
                   556667777899999999999***********976.899999999887 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.22
  Arylesterase  51 sglssanGInidadkkyiyvadilres 77 
                   ++++ + G++i++++ +i+ ad+ ++ 
    EFC35279.1 162 AKIYLPFGLTISPNDDVIF-ADVNNNR 187
                   5678899********9998.5665555 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.14
  Arylesterase  42 spsevkvvasglssanGInidadkkyiyvadilresi 78 
                   +++ ++   ++++++ G+ + +++ + +v d+l++ i
    EFC35279.1 268 NGDYINATSAKINTPAGVSVATNNEVYFV-DSLNNRI 303
                   55556667778899999999887765555.5666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       724  (0.0403815); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 1973.04
//
Query:       EFC35280.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.6e-14   52.5   1.6    9.2e-14   52.4   0.2    1.7  2  DUF1963         Domain of unknown function (DUF1963)
  ------ inclusion threshold ------
       0.51   10.8   4.5        1.1    9.7   4.5    1.5  1  CENP-B_dimeris  Centromere protein B dimerisation domain


Domain annotation for each model (and alignments):
>> DUF1963  Domain of unknown function (DUF1963)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.38   3.4e+03     103     116 ..     108     121 ..      48     149 .. 0.47
   2 !   52.4   0.2     1e-17   9.2e-14       1     140 [.     158     309 ..     158     341 .. 0.60

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.38
                 STTHHHHHTS-HHH CS
     DUF1963 103 dyrfeellleelee 116
                 +y+++++  +e+++
  EFC35280.1 108 KYSISNRSEAEINS 121
                 33333333333322 PP

  == domain 2  score: 52.4 bits;  conditional E-value: 1e-17
                 -EESS----BTTS---B-TTS-B-EEEEEEEGGGS--.-TTS...-.SS-EEEEEE.-SSSSSTT--SS-.--SSEEEEEESS-----SB......... CS
     DUF1963   1 SklGGlPylpkgaewPtdedgeplsflaQiNlaelpa.ledf...P.ekGlLqfFidleeedlygldped.sqegfrviYledveedfpl......... 84 
                 Sk+GG P+lpkg++wP+ e+    +f aQiNl+ l+  ++     P e G+L+fF    e +  g   +  s + + viY+   + + ++         
  EFC35280.1 158 SKVGGSPDLPKGMKWPKIEE--KFMFGAQINLQHLAYyDRTNsivPqEGGMLYFFCPE-EASGCGNYCNPnSSKPQPVIYVTAKQIK-EMgglerrnge 252
                 9*****************98..79*************7755579984668*****964.44444433322469999*****999988.55555656664 PP

                 ....-S-EEEEE.EE..EEE---TTSTTHHHHHTS-HHHHHHGGGGGHHHHHHHHHHT..--S CS
     DUF1963  85 ....edefklsf.el..eeekislpdyrfeellleeleeeeeeeaeeleeeyleeyeeeseeg 140
                           ++ +l  +++++++  yr +  + +e  +++++   ++eee  +e +e++e++
  EFC35280.1 253 gssyC-----HAaKLlfHNDEFNPR-YRTQMVFGKEDFNSDIDIYGDEEEEEEDEEKEKDEKN 309
                 33330.....332333333333322.3333333332222222221111111111111112222 PP

>> CENP-B_dimeris  Centromere protein B dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   4.5   0.00012       1.1       4      41 ..     276     312 ..     274     325 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00012
  CENP-B_dimeris   4 qlleagedsesesdeeeeeeeedeededeeddedddev 41 
                     q++ + ed +s+ d   +eee +eede++e de + +v
      EFC35280.1 276 QMVFGKEDFNSDIDIYGDEEE-EEEDEEKEKDEKNHNV 312
                     566678999999886655443.4455555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       805  (0.0448993); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 2012.50
//
Query:       EFC35281.1  [L=219]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-06   29.4   0.9    1.8e-06   28.7   0.2    1.7  2  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
    8.9e-06   25.0   0.0    1.3e-05   24.4   0.0    1.3  1  Pox_C4_C10      Poxvirus C4/C10 protein


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.67     6e+03      63      78 ..      25      40 ..       5      77 .. 0.57
   2 !   28.7   0.2     2e-10   1.8e-06       2      54 ..     151     201 ..     150     219 .] 0.78

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.67
                    TT-EEEEE-..B-TEE CS
  2OG-FeII_Oxy_3 63 kgrlvlFesdellpHe 78
                    +g+ v+ + ++++ H+
      EFC35281.1 25 PGDEVIVKERIVQVHS 40
                    4444444444443343 PP

  == domain 2  score: 28.7 bits;  conditional E-value: 2e-10
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--EEE..... CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekeseeGGelelyekdk 54 
                      +++y+ g+++k H+D   k++++++ ++t+l+yLn  ++++GGe ++y++ +
      EFC35281.1 151 RFNKYQIGEYFKIHTDGQFKRNNNERSIYTLLIYLN--DDFKGGETRFYNDPE 201
                     6899*999********9888888899*********8..789*******88764 PP

>> Pox_C4_C10  Poxvirus C4/C10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.0   1.5e-09   1.3e-05      37     119 ..     105     200 ..      67     206 .. 0.73

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 1.5e-09
  Pox_C4_C10  37 lenslnkdlveklknliydqlknvvs....................evevenkvtlvkyekgdyfkrtrn.lstklskntveyylvlyLekpeeGGetk 114
                 ++        + l  li+d+lk+ ++                       v++ + + ky+ g+yfk +++ + +++ ++   y+l++yL+   +GGet+
  EFC35281.1 105 ID--------ADLASLIFDKLKTRIDldaiskmvtpfgvdsagtwkACGVNEMMRFNKYQIGEYFKIHTDgQFKRNNNERSIYTLLIYLNDDFKGGETR 195
                 22........235555666666655555666666699999999998889*********************888888889999***************** PP

  Pox_C4_C10 115 iyikp 119
                 +y +p
  EFC35281.1 196 FYNDP 200
                 *9554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       546  (0.0304535); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1341.32
//
Query:       EFC35282.1  [L=203]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-52  178.3   0.2    2.1e-52  178.1   0.2    1.0  1  Pkinase        Protein kinase domain
    2.5e-29  102.3   0.0    3.1e-29  102.0   0.0    1.0  1  Pkinase_Tyr    Protein tyrosine kinase
    4.6e-06   25.8   2.0    9.9e-06   24.7   2.1    1.3  1  Haspin_kinase  Haspin like kinase domain
      2e-05   24.0   0.0    2.6e-05   23.7   0.0    1.1  1  Kdo            Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.059   13.0   0.2        0.4   10.3   0.2    2.0  2  FTA2           Kinetochore Sim4 complex subunit FTA2


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  178.1   0.2   5.9e-56   2.1e-52       1     175 [.      22     201 ..      22     203 .] 0.95

  Alignments for each domain:
  == domain 1  score: 178.1 bits;  conditional E-value: 5.9e-56
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.....SSEEEEEEE--TTEBHHHHHHHHSS CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladllerkgs 94 
                 y+ ++ +G G++G V ++++k+t+++vA+Kk+ k  ++  + k++lrEi++l++++h+ni+ ++++++       +++y+v+e+++++ l ++++ k++
  EFC35282.1  22 YSIIKPIGYGAYGFVCSGIDKKTNEKVAIKKVPKLFQDLVDGKRILREIELLRTFRHSNIISVKDIMTIpdkntFSDVYIVNELMDTD-LYQVIKSKQV 119
                 678899*************************************************************9877777889*********76.********** PP

                 --HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.TTSCBS CS
     Pkinase  95 lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl.keneys 175
                 ls+++++ +++qil+gl+y+H  +++HrDlKp+NiL++e+ ++Ki+D+Gla+ ++++s++t++v+t++Y+APE++   ++y+
  EFC35282.1 120 LSSDHIQYFVYQILRGLKYIHTSNVLHRDLKPSNILVNENCDVKICDLGLARGFDNNSEMTEYVVTRWYRAPELVlMCKDYG 201
                 *************************************************************************997667776 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  102.0   0.0   8.7e-33   3.1e-29       3     177 ..      24     194 ..      22     200 .. 0.86

  Alignments for each domain:
  == domain 1  score: 102.0 bits;  conditional E-value: 8.7e-33
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEEST.TSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE..SSSS....EEEEEE--TTEBHHHHHH CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlke.eateeekeelleeakimkklkhpnivkllgvct..keep....llivteyvkgGdLlkfLr 93 
                  + k +G Ga+G V++g  k    k+++kVa+K++ +  ++  + +++l+e++++++++h ni+++  ++t  + ++    ++iv e+++  dL + ++
   EFC35282.1  24 IIKPIGYGAYGFVCSGIDK----KTNEKVAIKKVPKlFQDLVDGKRILREIELLRTFRHSNIISVKDIMTipD-KNtfsdVYIVNELMDT-DLYQVIK 115
                  6789************999....9999*******66155556799*************************852.3346779*******86.9****** PP

                  HTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS.-HHHH CS
  Pkinase_Tyr  94 kkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWm.apEsl 177
                  +k  + l+ +++  f++q+ +G++y+++ +++Hrdl   N+L++en  vki+D GLar   +    +++ ++ +  +W+ apE +
   EFC35282.1 116 SK--QVLSSDHIQYFVYQILRGLKYIHTSNVLHRDLKPSNILVNENCDVKICDLGLARGFDN----NSEMTEYVVTRWYrAPELV 194
                  98..9*******************************************************33....3344455666666599976 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.7   2.1   2.8e-09   9.9e-06     122     261 ..      44     177 ..      36     186 .. 0.68

  Alignments for each domain:
  == domain 1  score: 24.7 bits;  conditional E-value: 2.8e-09
  Haspin_kinase 122 kdkevvlKviplevledvtiskelslkelkslklvkgtypglllllqdkvlkekpdfyseqqlflvlllkdkGtdLeev....klkswkqalsifw 213
                    ++++v++K++p    +d+   k + l e + l+ ++ +    ++ ++d ++  +    +++   ++++ + + tdL +v    ++ s ++++   +
     EFC35282.1  44 TNEKVAIKKVPK-LFQDLVDGKRI-LREIELLRTFRHS---NIISVKDIMTIPD----KNTFSDVYIVNELMDTDLYQVikskQVLSSDHIQYFVY 130
                    577888888886.67777666544.6788888877776...3333344333333....35555566666777799999884444555555555566 PP

  Haspin_kinase 214 qivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRlesseg 261
                    qi+  L+   t+ +  HRdL+  niLv++n  v ++dl l+R  ++++
     EFC35282.1 131 QILRGLKYIHTS-NVLHRDLKPSNILVNENCDVKICDLGLARGFDNNS 177
                    666666666665.567**************************764444 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0   7.2e-09   2.6e-05      53     161 ..      61     164 ..      37     177 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 7.2e-09
         Kdo  53 lgrtravrEfrllkrLeeagvavpkpvaagavkvgleyrAlllterlegaqdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknill 151
                 ++  r+ rE++ll+ +++  +   k ++     ++ +    ++ e ++   dL +++++ ++l+    +  + ++ r  + +h  +v H+dl + nil+
  EFC35282.1  61 VDGKRILREIELLRTFRHSNIISVKDIMTIP-DKNTFSDVYIVNELMD--TDLYQVIKSKQVLSSDHIQYFVYQILRGLKYIHTSNVLHRDLKPSNILV 156
                 566799********************98765.556778899***9999..5*******9888************************************* PP

         Kdo 152 qqeeeeeaei 161
                 +++   + +i
  EFC35282.1 157 NENC--DVKI 164
                 9987..4444 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0       0.1   3.6e+02     160     187 ..      24      62 ..      17      71 .. 0.74
   2 ?   10.3   0.2   0.00011       0.4     173     212 ..     124     168 ..      68     171 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.1
        FTA2 160 IVKel...........ellkeqeelevsqlpkllrdlkk 187
                 I+K+              +k +e++ ++++pkl +dl +
  EFC35282.1  24 IIKPIgygaygfvcsgIDKKTNEKVAIKKVPKLFQDLVD 62 
                 566656666666665545678899999********9987 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00011
        FTA2 173 levsqlpkllrdlkklhklgIvvrDlkeenyi.....dgkLvDls 212
                  ++  + ++lr lk +h + +++rDlk++n++     d k++Dl+
  EFC35282.1 124 HIQYFVYQILRGLKYIHTSNVLHRDLKPSNILvnencDVKICDLG 168
                 33334679**********************973333255666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       630  (0.0351386); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.57u 0.38s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1149.53
//
Query:       EFC35283.1  [L=124]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.3e-10   37.5   0.1    8.9e-10   37.4   0.1    1.0  1  HSP70     Hsp70 protein
  ------ inclusion threshold ------
       0.17   10.9   0.0        0.2   10.7   0.0    1.2  1  PhoD      PhoD-like phosphatase


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.4   0.1     1e-13   8.9e-10     441     528 ..      24     111 ..       4     123 .. 0.78

  Alignments for each domain:
  == domain 1  score: 37.4 bits;  conditional E-value: 1e-13
                 SBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEEEEETTTCCEEEEEEECCSSSBHHHHHHHHHHHHHCHHHHHHHHHHH CS
       HSP70 441 elvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvsakdketgkeeeitieaseglseeeiekmvkdaeesaeedkkkkeai 528
                   +++n +lg+ +l+gi+ + +G++qieV+f++  + il+v+a+d +t++++e  i+ ++  s+ e  +  ++  + + e+k+ ++  
  EFC35283.1  24 YEMEKNIQLGQLTLEGIELTEKGKSQIEVSFELSDSFILNVTATDLTTKEKSEKLISLEKLESNRELTNKLEQDASKDGEEKEIRKLL 111
                 4568899*****************************************9999999999999776666554444444555555555554 PP

>> PhoD  PhoD-like phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   2.2e-05       0.2      24      42 ..      11      29 ..       4      74 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 2.2e-05
        PhoD 24 edlDlvlhlGDyiYeygpg 42
                +++D+ ++ GD iYe +++
  EFC35283.1 11 DSVDFCIFAGDNIYEMEKN 29
                479************9633 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (124 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1076  (0.0600145); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.35s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 706.95
//
Query:       EFC35284.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.9e-11   41.7   9.7    1.5e-10   40.7   9.7    1.5  1  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
    2.9e-10   39.8   6.6    4.5e-10   39.2   6.6    1.2  1  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
    1.6e-09   37.5   9.2      3e-09   36.5   9.2    1.5  1  zf-C3HC4_2    Zinc finger, C3HC4 type (RING finger)
    2.1e-09   37.2   7.1    4.6e-09   36.2   7.1    1.6  1  zf-RING_UBOX  RING-type zinc-finger
    3.5e-09   36.7  10.0    7.2e-09   35.7  10.0    1.6  1  zf-C3HC4_4    zinc finger of C3HC4-type, RING
    3.9e-09   36.3   8.5    6.1e-09   35.7   8.5    1.3  1  zf-RING_5     zinc-RING finger domain
    4.4e-09   36.5  11.0    7.1e-09   35.9  11.0    1.4  1  zf-RING_2     Ring finger domain
    3.4e-06   26.8   6.8    6.8e-06   25.9   6.8    1.5  1  Prok-RING_4   Prokaryotic RING finger family 4
    5.1e-05   23.5   7.6    0.00012   22.3   7.6    1.7  1  zf-rbx1       RING-H2 zinc finger domain
    0.00027   20.9   7.2    0.00034   20.6   6.6    1.5  1  Baculo_IE-1   Baculovirus immediate-early protein (IE-0)
     0.0023   17.9   7.2     0.0044   17.0   7.2    1.5  1  zf-ANAPC11    Anaphase-promoting complex subunit 11 RING-H2 f
  ------ inclusion threshold ------
      0.021   15.0   0.6       0.13   12.4   0.0    2.5  3  U-box         U-box domain
      0.035   14.0   4.2      0.079   12.8   4.2    1.5  1  zf-RING_6     zf-RING of BARD1-type protein
       0.14   12.0   0.3       0.14   12.0   0.3    2.0  1  GAGA          GAGA factor
       0.15   11.8  11.6       0.79    9.5   6.6    2.3  2  zf-MIZ        MIZ/SP-RING zinc finger
        2.2    8.2   8.5        5.9    6.8   8.4    1.8  1  zf-RING_4     RING/Ubox like zinc-binding domain
        2.3    6.9   7.9        2.6    6.7   7.9    1.3  1  Presenilin    Presenilin
        4.3    6.2  14.3        4.9    6.0  13.6    1.4  1  Miga          Mitoguardin
        6.1    5.3  20.6        6.4    5.2  20.6    1.2  1  Macoilin      Macoilin family
          7    4.9  11.8        9.2    4.5  11.8    1.3  1  Menin         Menin


Domain annotation for each model (and alignments):
>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.7   9.7   1.7e-13   1.5e-10       1      41 []     140     181 ..     140     181 .. 0.96

  Alignments for each domain:
  == domain 1  score: 40.7 bits;  conditional E-value: 1.7e-13
                 -TTT-S--SS-E.E-TTS--B-CHHHHHHHHC..TSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepnelleCkHsfCskCirkilks..rkkvkCPlC 41 
                 C+iC+++a+ep+ +++C+H +C +Ci ++++s   ++ +CP+C
  EFC35284.1 140 CNICFDTASEPV-ITQCGHLYCWSCIYRWMQShsTQNLQCPVC 181
                 ************.*******************8888888**** PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.2   6.6   5.1e-13   4.5e-10       4      49 ..     139     187 ..     136     187 .. 0.95

  Alignments for each domain:
  == domain 1  score: 39.2 bits;  conditional E-value: 5.1e-13
                 B-TTTSSSBS-EEETTEEEEEE-HHHHHHHHH....TT-B-TTT--B--E CS
  zf-C3HC4_3   4 eCviClerprnvvllpCgHlvlCeeCaekllk....rkkkCpiCrrpiek 49 
                  C iC+++ ++ v+ +CgHl +C +C  ++++    ++ +Cp+C++ i++
  EFC35284.1 139 SCNICFDTASEPVITQCGHL-YCWSCIYRWMQshstQNLQCPVCKAGIQQ 187
                 6*******************.*********999************99985 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.5   9.2   3.4e-12     3e-09       2      40 .]     140     181 ..     139     182 .. 0.90

  Alignments for each domain:
  == domain 1  score: 36.5 bits;  conditional E-value: 3.4e-12
  zf-C3HC4_2   2 CpiCldmlkdpsvvtpCgHvfCqkCilrsLeek...n.eCPlC 40 
                 C iC+d  ++p v+t+CgH +C +Ci r+++++   n +CP+C
  EFC35284.1 140 CNICFDTASEP-VITQCGHLYCWSCIYRWMQSHstqNlQCPVC 181
                 ***********.******************986333588**** PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.2   7.1   5.1e-12   4.6e-09       1      39 []     140     179 ..     140     179 .. 0.92

  Alignments for each domain:
  == domain 1  score: 36.2 bits;  conditional E-value: 5.1e-12
  zf-RING_UBOX   1 CpIClelftdPlv.lpCGHtFCreCl..welskslegafkCP 39 
                   C IC+++ ++P v + CGH +C++C+  w +++++ ++++CP
    EFC35284.1 140 CNICFDTASEP-ViTQCGHLYCWSCIyrW-MQSHSTQNLQCP 179
                   ***********.6479**********744.9**********9 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.7  10.0     8e-12   7.2e-09       1      42 []     140     181 ..     140     181 .. 0.99

  Alignments for each domain:
  == domain 1  score: 35.7 bits;  conditional E-value: 8e-12
  zf-C3HC4_4   1 CPiCldYLekPvsleCGhsfClsCisslqkepdgeqllCplC 42 
                 C iC d  ++Pv  +CGh +C sCi++++++ + ++l+Cp+C
  EFC35284.1 140 CNICFDTASEPVITQCGHLYCWSCIYRWMQSHSTQNLQCPVC 181
                 9*********************************9******* PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.7   8.5   6.8e-12   6.1e-09       2      43 ..     140     182 ..     139     183 .. 0.96

  Alignments for each domain:
  == domain 1  score: 35.7 bits;  conditional E-value: 6.8e-12
   zf-RING_5   2 CnkCfeklskeekfyltsCgHifCekClkkll....ekeavCpiCr 43 
                 Cn+Cf+     +++++t+CgH +C++C+ + +    +++ +Cp+C+
  EFC35284.1 140 CNICFDTA---SEPVITQCGHLYCWSCIYRWMqshsTQNLQCPVCK 182
                 ********...99********************************8 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9  11.0   7.9e-12   7.1e-09       2      44 .]     139     182 ..     138     182 .. 0.89

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 7.9e-12
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreClerwlrssst....CPlCr 44 
                 +C IC+   ++a+++++++CgH ++++C+ rw++s+st    CP+C+
  EFC35284.1 139 SCNICF---DTASEPVITQCGHLYCWSCIYRWMQSHSTqnlqCPVCK 182
                 6****7...6666667677***************************7 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   6.8   7.6e-09   6.8e-06       1      43 [.     140     188 ..     140     191 .. 0.87

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 7.6e-09
  Prok-RING_4   1 CvlCgeqekkailepCgHlvCkeCfdskdls......sCPlCqrrisks 43 
                  C +C    +++++  CgHl C +C   +  s      +CP+C+  i+++
   EFC35284.1 140 CNICFDTASEPVITQCGHLYCWSCIYRWMQShstqnlQCPVCKAGIQQD 188
                  99**********************9999544467889******998776 PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   7.6   1.3e-07   0.00012      24      55 .]     139     182 ..     118     182 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 1.3e-07
     zf-rbx1  24 e........cpvvlGeCgHaFHlhCiskWlkt....rkvCPlcr 55 
                 +          +v+ +CgH +   Ci +W+++    + +CP+c+
  EFC35284.1 139 ScnicfdtaSEPVITQCGHLYCWSCIYRWMQShstqNLQCPVCK 182
                 033333333668889****************99998889****6 PP

>> Baculo_IE-1  Baculovirus immediate-early protein (IE-0)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   6.6   3.8e-07   0.00034      75     135 ..     132     189 ..      88     192 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 3.8e-07
  Baculo_IE-1  75 flekklyqcnicedtsaeerflkPneccGykicnlc.yanlwkfstvyPvcPvcktsfksss 135
                   ++ +++ cnic dt++e       + cG+  c  c y  +  +st   +cPvck++ ++++
   EFC35284.1 132 NDDDNMWSCNICFDTASEPVI----TQCGHLYCWSCiYRWMQSHSTQNLQCPVCKAGIQQDK 189
                  45779***********99876....46*******997788999*************998876 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   7.2   4.9e-06    0.0044      38      81 ..     140     185 ..     132     189 .. 0.78

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 4.9e-06
                 CSTTTTTS-.EEEBTTS-EEEHHHHHHHHHHHSTSS.B-TTTSSB- CS
  zf-ANAPC11  38 ckfpGddcp.lvlGkckhnfhlhcilkwletetskg.lcpmcrqtf 81 
                 c++  d  +  v+ +c h +   ci++w++++++++ +cp+c+  +
  EFC35284.1 140 CNICFDTASePVITQCGHLYCWSCIYRWMQSHSTQNlQCPVCKAGI 185
                 55555554315899****************99887637****9765 PP

>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2       2.2     2e+03      31      61 ..      60      89 ..      52     103 .. 0.68
   2 ?   -1.5   0.1       3.3   2.9e+03      19      37 ..     102     120 ..      96     134 .. 0.67
   3 ?   12.4   0.0   0.00015      0.13       6      56 ..     139     192 ..     135     195 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 2.2
                HHHHHTT.SSB-TTT-SB--GGGSEE-HHHH CS
       U-box 31 iekhllsrdktdPftrepltqdqlipnlelK 61
                i++ ++s ++++  ++++ ++++ + n el 
  EFC35284.1 60 INEINQS-SSSSTTNNNTSSSSDSTNNNELN 89
                5555666.66666667777777777777764 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 3.3
                 EETTTEEEEHHHHHHHHTT CS
       U-box  19 ilpsgvvvdrstiekhlls 37 
                 i ps+ +   stie    s
  EFC35284.1 102 INPSSSSPSSSTIETLKSS 120
                 6677777777777765554 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 0.00015
                 B-TTT-SB-SSEEEETTTEEEEHHHHHHHHTT....SSB-TTT-SB--GGGSEE CS
       U-box   6 ldpitlelmkdPvilpsgvvvdrstiekhlls...rdktdPftrepltqdqlip 56 
                  ++i +    +Pvi+  g+ +  s i ++++s   ++  +P+ ++ ++qd+lip
  EFC35284.1 139 SCNICFDTASEPVITQCGHLYCWSCIYRWMQShstQNLQCPVCKAGIQQDKLIP 192
                 699999999***********************87777789************99 PP

>> zf-RING_6  zf-RING of BARD1-type protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   4.2   8.8e-05     0.079       7      48 ..     137     183 ..     134     191 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 8.8e-05
   zf-RING_6   7 llrcsrctdilrepvclggcehifcsncisdcfgs......gcpvcyt 48 
                 +  c  c d   epv    c h++c  ci   + s       cpvc +
  EFC35284.1 137 MWSCNICFDTASEPVI-TQCGHLYCWSCIYRWMQShstqnlQCPVCKA 183
                 5679**********95.78**********8877663333335999964 PP

>> GAGA  GAGA factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.3   0.00016      0.14      18      37 ..     169     188 ..     157     191 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00016
                 CCTTS--EE-TTT--EESSH CS
        GAGA  18 ksqsEqPAtCPiCqAviRqs 37 
                 +s s q   CP+C+A i q 
  EFC35284.1 169 QSHSTQNLQCPVCKAGIQQD 188
                 7999*************996 PP

>> zf-MIZ  MIZ/SP-RING zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.2     0.026        23      36      47 ..     132     143 ..     124     146 .. 0.73
   2 ?    9.5   6.6   0.00088      0.79      20      49 ..     154     183 ..     150     184 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.026
                 HHHS---B-TTT CS
      zf-MIZ  36 nertetWnCPvC 47 
                 n+  + W+C +C
  EFC35284.1 132 NDDDNMWSCNIC 143
                 445567****** PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00088
                 T--SS--EEHHHHHHHHHHS---B-TTT-- CS
      zf-MIZ  20 kCkHlqCfdlesylelnertetWnCPvCsk 49 
                 +C Hl C  +    ++++ t++ +CPvC++
  EFC35284.1 154 QCGHLYCWSCIYRWMQSHSTQNLQCPVCKA 183
                 8*********999999999*********86 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   8.4    0.0066       5.9      18      45 ..     153     183 ..     139     184 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0066
   zf-RING_4  18 CeCgyqiClfCyhrile...eeegrCPaCre 45 
                  +Cg+  C+ C  r ++   +++ +CP C+ 
  EFC35284.1 153 TQCGHLYCWSCIYRWMQshsTQNLQCPVCKA 183
                 58*********9999886656799*****95 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   7.9    0.0029       2.6     237     310 ..      56     131 ..       6     177 .. 0.53

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0029
  Presenilin 237 eeeeaekkkeeasesskeeeseeesseksaqsse..seeeseeesseaessaeesseekeseessesseeeeeeee 310
                 +++  ++ ++++s+s+++++++++s ++++++ +  + ++++++s  ++ss++ ss++ e+ +ss++s++++++ee
  EFC35284.1  56 QSTFINEINQSSSSSTTNNNTSSSSDSTNNNELNnnNINNTTTTSIINPSSSSPSSSTIETLKSSSNSTNTQQQEE 131
                 2222222222222222222222222222222221111111111111111111111111121222222222221111 PP

>> Miga  Mitoguardin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0  13.6    0.0055       4.9      47     147 ..      53     152 ..      45     190 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0055
        Miga  47 saeqeelakevlktasvkkrasekksrssssksndtlslas..skassssaklsgslqslasvksvnsssssaaansaswdkeeeeelklenitvltpe 143
                 +++q+++++e+ +++ +  ++ +++s+ss s +n+ l ++   +++++s +++s+s+ s + +++++sss s+++  ++ ++++++++   ni   t+ 
  EFC35284.1  53 NTNQSTFINEINQSS-SSSTTNNNTSSSSDSTNNNELNNNNinNTTTTSIINPSSSSPSSSTIETLKSSSNSTNT--QQQEENDDDNMWSCNICFDTAS 148
                 456677777777776.333444555555555666667666622333344459********************999..5667777788888888877776 PP

        Miga 144 nlyl 147
                 +  +
  EFC35284.1 149 EPVI 152
                 6555 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2  20.6    0.0071       6.4     232     354 ..       7     129 ..       1     212 [. 0.50

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0071
    Macoilin 232 valsknnhslnkkdsslklpeleyrekkksakssrsdskkkhehnesvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssn.. 328
                 +a++ nn+ l++++ s ++ el+      +  s+ sds+  h +n              n+ +s+ +++ ++s+s+s+++ + s++s s+ +++ +n  
  EFC35284.1   7 TATTSNNNMLSSSSPSSQMNELDDDPIIVDYVSDISDSEDLHYQNI-------------NTNQSTFINEINQSSSSSTTNNNTSSSSDSTNNNELNNnn 92 
                 4444444455554555555555555554444444444433333221.............1112222222222222233333333222222222222200 PP

    Macoilin 329 ...........knskkasagsagssnssskkhsessk 354
                            ++s++ s++++++ +sss++ +++++
  EFC35284.1  93 innttttsiinPSSSSPSSSTIETLKSSSNSTNTQQQ 129
                 0000000000033333333333333333333333322 PP

>> Menin  Menin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5  11.8      0.01       9.2     526     594 ..      62     132 ..       5     154 .. 0.58

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.01
       Menin 526 qkqkkageeserreannnnnsksnsekeadkk......asttsnggeasstpsseseaavespsehkeakleeks 594
                 + ++++++++++    nn +s s+s ++ + +      ++tts  + +ss+pss++ ++++s s+  +++++e++
  EFC35284.1  62 EINQSSSSSTTN----NNTSSSSDSTNNNELNnnninnTTTTSIINPSSSSPSSSTIETLKSSSNSTNTQQQEEN 132
                 333333322222....22222222222111111123335555666666667777777887777776555544443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2396  (0.133638); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        97  (0.00541023); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.73u 0.37s 00:00:01.10 Elapsed: 00:00:00.57
# Mc/sec: 1130.28
//
Query:       EFC35285.1  [L=104]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0076   15.9   0.0     0.0083   15.7   0.0    1.1  1  DUF3053   Protein of unknown function (DUF3053)
  ------ inclusion threshold ------
      0.028   14.8   1.4      0.028   14.8   1.4    2.1  2  Csm1_N    Csm1 N-terminal domain
      0.031   14.5   0.1      0.039   14.2   0.1    1.4  1  DUF1477   Protein of unknown function (DUF1477)


Domain annotation for each model (and alignments):
>> DUF3053  Protein of unknown function (DUF3053)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   1.4e-06    0.0083     121     185 ..      18      86 ..       2     100 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.4e-06
     DUF3053 121 dkaraaLkqpddlkavy....dkayektVtqpanaltpllplaeallqqlvqvgdflqkqgnqvefegn 185
                 +++r aLk   +l + +     + y+k++t+ +++++ l ++  ++ +  ++v  ++ k++++ e++++
  EFC35285.1  18 REERDALKRKVELEEGFyeycMQFYQKIITENKKKMELLENQFGEIEALSIEVSSYITKRREKLEIQDK 86 
                 344555555555555442222699****************************************99876 PP

>> Csm1_N  Csm1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.52   3.1e+03      41      50 ..      19      28 ..       2      32 .. 0.52
   2 ?   14.8   1.4   4.7e-06     0.028      23      64 ..      43      84 ..      41      90 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.52
      Csm1_N 41 qeiesLkeql 50
                +e  +Lk+++
  EFC35285.1 19 EERDALKRKV 28
                3344444444 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 4.7e-06
      Csm1_N 23 sklvhENsvLsqkletkdqeiesLkeqlaeleekvkeleerr 64
                +k++ EN  +++ le++  eie+L  ++ +  +k++e  e +
  EFC35285.1 43 QKIITENKKKMELLENQFGEIEALSIEVSSYITKRREKLEIQ 84
                79**************************99888877766554 PP

>> DUF1477  Protein of unknown function (DUF1477)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.1   6.6e-06     0.039      36      71 ..      28      63 ..       4      83 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 6.6e-06
     DUF1477 36 rngrklfyelcisfvkklltknslaletlknlfdti 71
                 + ++ fye+c++f +k++t+n+ ++e l+n f  i
  EFC35285.1 28 VELEEGFYEYCMQFYQKIITENKKKMELLENQFGEI 63
                556788************************999776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (104 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1746  (0.0973841); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 670.59
//
Query:       EFC35286.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        3.9    7.9   6.8        5.8    7.4   6.6    1.5  1  DBR1      Lariat debranching enzyme, C-terminal domain


Domain annotation for each model (and alignments):
>> DBR1  Lariat debranching enzyme, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   6.6   0.00032       5.8      72     126 ..      23      85 ..       3      99 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00032
        DBR1  72 eaelaelieeelawveeni......vekgklkipenFertaP..ageeeaeekeqpkeytNpQ 126
                  ++  +++ ++l+ +e n       +  + +  p+nF++taP   +++++  ++qp+e  N Q
  EFC35286.1  23 INRITPQTVSQLRPIESNAptitnpQIYNSFVRPNNFVTTAPpaIARPNNFPQTQPHEAMNLQ 85 
                 5555556666666666666666655678999**********8652233367777777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       365  (0.0203581); expected 358.6 (0.02)
Passed bias filter:                      275  (0.0153383); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.31s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 772.75
//
Query:       EFC35287.1  [L=179]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      171  (0.00953762); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 1160.23
//
Query:       EFC35288.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1536  (0.0856713); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 791.25
//
Query:       EFC35289.1  [L=430]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.4e-77  259.1   0.0    9.5e-45  153.1   0.0    2.6  2  Ald_Xan_dh_C2    Molybdopterin-binding domain of aldehyde deh


Domain annotation for each model (and alignments):
>> Ald_Xan_dh_C2  Molybdopterin-binding domain of aldehyde dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.0   0.1     8e-34   1.4e-29     131     236 ..       1     107 [.       1     160 [. 0.86
   2 !  153.1   0.0   5.3e-49   9.5e-45     237     452 ..     162     429 ..     154     430 .] 0.87

  Alignments for each domain:
  == domain 1  score: 103.0 bits;  conditional E-value: 8e-34
                    HHHS-EEEEEEEEEEEEE-T.TS-EEEEEEEEEEEESSTHHHCHCCHCCTTGGGTTTB--SEEEEEEEEEE-SSS-EE-SSTTTHHHHHHHHHHHH CS
  Ald_Xan_dh_C2 131 mlatgkrhpfkikykvgadk.dGkitaldvdlladaGayadlspavleralshldgpYkipnvrvegrvvytNtppntafRGfGgpqamfalErlm 225
                    m +tg+rhp+++kykv++ k   k+ a++++l+a++G+++dls++vl+ral+ +d++Y ip   + gr+++tNt +ntafRGfGgpq+++a+E ++
     EFC35289.1   1 MSTTGQRHPYYVKYKVAIHKfTFKLHAIEMELIANGGYSMDLSESVLNRALQCADNCYYIPYSTIIGRICKTNTLSNTAFRGFGGPQGCMAMELIL 96 
                    789***************99456************************************************************************* PP

                    HHHHHHHT--H CS
  Ald_Xan_dh_C2 226 delAeelgldp 236
                    d+l ++l l  
     EFC35289.1  97 DHLSHQLSLYH 107
                    ******98854 PP

  == domain 2  score: 153.1 bits;  conditional E-value: 5.3e-49
                    HHHHHHHBCE.CGCC.SEEETEESSS-HHHHHHHHHHHHTHHHHHHSCCHHC.CT.ECEEEEEEEEEEEEBS--S.EETTEEEEEEEEE-.TTS-E CS
  Ald_Xan_dh_C2 237 lelRrrNlik.pgeltpygqpvydsgdlpelldklkessdyeerraeqaefn.ag.wkkrGiglapvvegiglgftakflnqegalvrvn.tdGsv 328
                    ++lR+ N+++ ++++tpy+++++ds+++++l++++ + s+ye+r + ++e+n ++  +k+G++++pv++gi  +f+a flnq+gal++++ +d sv
     EFC35289.1 162 IKLRQVNFYNnENNITPYKMKIMDSYRIERLFNETIKCSNYENRLKLIEEYNlKNrYRKKGMSIIPVKFGI--AFGAPFLNQGGALIQIYfNDASV 255
                    68*******7245669************************************7557888************..777799***********99**** PP

                    EEEESS--SSS-HHHHHHHHHHHHHT--GGGEEEE-SBTTSSS----S-TT-HHHHHHHHHHHHHHHHHHHHHHHHH....HHCTS-CCCEEEETT CS
  Ald_Xan_dh_C2 329 tvstggtemGqGletklaqiaaeeLgvpledvrvvegdtdkvpngsgtaaSrstdlngnAvkkAaeklrerllkiaa....ellevspedleledg 420
                    ++s+gg+ mGqGl  k++q ++++Lg+ple +++++++tdkvpn+s+taaS s+dl+g+Av kA+++l++rl  ++     +l+  + + l+  ++
     EFC35289.1 256 LLSIGGVCMGQGLFIKMIQCVSTTLGIPLEFIHLSDTSTDKVPNTSATAASVSSDLYGQAVIKACQTLNNRLDSLKRklfpHLYYDENDHLNNLNN 351
                    *****************************************************************************8886444444444444333 PP

                    EEEET.EEEE............................................CHHHHHHHHHH.TTSSEEEEEEE. CS
  Ald_Xan_dh_C2 421 kvvvk.eksv............................................slaelaaaayl.ervslsatgfyk 452
                    +   + ++++                                            +++el+++ay+  ++slsatg+y+
     EFC35289.1 352 NTNNNtNNNMnnntndmnnnlnninnldnsiiredlntiikqdlerlppkltseEWKELIKNAYFqGDISLSATGYYS 429
                    3333332222455566788889999999999******************************99996788*******95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (430 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1591  (0.0887389); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2826.27
//
Query:       EFC35290.1  [L=438]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (438 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.47
# Mc/sec: 2802.99
//
Query:       EFC35291.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.014   15.7   0.3        8.9    6.8   0.1    2.4  2  DUF2172   Domain of unknown function (DUF2172)


Domain annotation for each model (and alignments):
>> DUF2172  Domain of unknown function (DUF2172)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.1    0.0005       8.9       4      63 ..      11      73 ..      10      78 .. 0.74
   2 ?    6.7   0.0   0.00052       9.4      51      90 ..     133     172 ..     106     174 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0005
                EEEEEEE-TTS-EEEETTT-G.GGB-BT---.EEEEEEHHHHG.GGEE--TTSTT--B--B-S CS
     DUF2172  4 irdayikdskGerivdfkknn.LhvvgySvp.vdktlsleeLk.khlhtlpeqpdaipyrtsy 63
                i+d +ik+ +  r ++f+++n  h+v+yS++ +++t++   L+ k + + ++  +++p +t y
  EFC35291.1 11 INDQQIKKYEEYRDINFRDENgRHLVHYSTNcFSATIQHLGLElKDVVFCKDDNQTMPIQTFY 73
                678889998888899998876379*****9746888887655424455567778888888776 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.00052
                 TTSTT--B--B-SSS----EE--HHHHHT--SSEEEEEEE CS
     DUF2172  51 peqpdaipyrtsyykeeWGFclsheelkeLkdgeYevvid 90 
                   +p+++   t+y +  + F+++++ l++L++ +Y  +id
  EFC35291.1 133 SGEPELVSLCTHYLNGLYHFSIEKSPLQQLRNIKYYGCID 172
                 67899*****************************998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       458  (0.0255452); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1480.29
//
Query:       EFC35292.1  [L=413]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.014   14.7   5.0       0.02   14.2   5.0    1.2  1  DUF4407        Domain of unknown function (DUF4407)
       0.03   14.7   3.5          1    9.7   0.1    2.6  2  HCMV_UL139     Human Cytomegalovirus UL139 protein
      0.032   14.3   1.7      0.047   13.8   0.0    2.1  2  MMR_HSR1       50S ribosome-binding GTPase
      0.066   13.1   5.7       0.78    9.6   5.7    2.4  1  Mt_ATP-synt_D  ATP synthase D chain, mitochondrial (ATP5H)
      0.088   13.3   1.5       0.15   12.6   0.2    2.0  2  DUF4724        Domain of unknown function (DUF4724)
       0.15   12.3  10.2       0.12   12.6   8.2    2.0  1  Fib_alpha      Fibrinogen alpha/beta chain family
        1.1    8.7  13.0       0.39   10.3  10.1    1.6  2  Exonuc_VII_L   Exonuclease VII, large subunit
          7    7.2  20.3          3    8.4  17.6    1.8  2  APG6_N         Apg6 coiled-coil region


Domain annotation for each model (and alignments):
>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   5.0   9.1e-06      0.02     131     235 ..     240     342 ..     184     347 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 9.1e-06
     DUF4407 131 ltaelaeleaqiaalqaeidaaearldalraeaqkeldgtkgtgttgvaGkgpaakekkaqldaaqaelaelkakld....atarlaalraelaeleae 225
                  +  +++ +++ia+l++ i++ ++rl++ +++  ++ +      ++ + G    + ekk++++++++el++l+  ++    ++++l ++++el++ e++
  EFC35292.1 240 IKRLMDQQKTNIAELNTRIESYSDRLKEIQKTNIEKES------EQVDYGLQRLYSEKKDEIKRLTQELDALNLLIKktqfSRDELLKKQKELDSEEEK 332
                 55556677777777777777777777776666664444......345789999********************99999999888888888888887777 PP

     DUF4407 226 rakeraasqa 235
                 ++ +++ s++
  EFC35292.1 333 QIFKEQISEK 342
                 7766665555 PP

>> HCMV_UL139  Human Cytomegalovirus UL139 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1   0.00046         1      63     113 ..     195     245 ..     177     247 .. 0.86
   2 ?    4.9   1.3     0.014        32      49      97 ..     247     297 ..     237     304 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00046
  HCMV_UL139  63 isrdlrslkgeveeaerkeeereryyeakrkemeeflpmgetfesearpqv 113
                  +++l+ +  e  e +  +e+++ry ++ rk mee  +  ++++   r  +
  EFC35292.1 195 AINNLCPVSCEYFETNTFDETWNRYNNVIRKVMEESIKFYDNYVNIKRLMD 245
                 57899******************************9998888777776655 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.014
  HCMV_UL139  49 lrseidaldakyvaisrdlrsl.kgeve.eaerkeeereryyeakrkemee 97 
                  +++i +l+++ +++s  l+++ k ++e e+e+ +   +r y  k+ e ++
  EFC35292.1 247 QKTNIAELNTRIESYSDRLKEIqKTNIEkESEQVDYGLQRLYSEKKDEIKR 297
                 589****************88734555437788888888999998888776 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   2.1e-05     0.047      32     113 ..      22     114 ..       8     116 .. 0.61
   2 ?   -1.9   0.5       1.5   3.4e+03      74      84 ..     300     310 ..     236     347 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.1e-05
                 SSSSEEEEEEEETTEEEEEEECGGCSS..HHHHHH....HHHHHHHHHHCTSEEEEEEETT.....TTCSHHHHHHHHHHHHH..TTSEEEEEEE CS
    MMR_HSR1  32 tTrdinegrvklkgkeielvDtpGlie..gaseek....glgkaflaleeadlillvvdas.....eeklkpldeeleellee..akkplilvln 113
                  T +++  r +  + e++++D+pG+++  g+ ++     +++ ++++  +++ i++++d+      ++k+++  + +  +l+e   +k +i+v+n
  EFC35292.1  22 ETSTPICVRNN--DCEYIILDCPGFFDnrGDLTRLmvnlSIRLSIQQALQVKGIVIMIDIDdlinrSSKFNETASLFGTMLKEdfPEKSMIVVIN 114
                 34444444444..789********875332222222333677788888889********986665433455554445555555776777888776 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.5
                 HCTSEEEEEEE CS
    MMR_HSR1  74 eeadlillvvd 84 
                 +e d++ l+++
  EFC35292.1 300 QELDALNLLIK 310
                 23444444444 PP

>> Mt_ATP-synt_D  ATP synthase D chain, mitochondrial (ATP5H)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   5.7   0.00035      0.78      53     143 ..     232     328 ..     210     336 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00035
                    HHHHHHSSSTTHHHHHHHHHHH-------......-TTTTHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXXXXXXXXXXX CS
  Mt_ATP-synt_D  53 ayYkknvakeglVdeFekkYealkipype......dkyteevdaeekevkkeikefkeeskkrieelekeleklksllpfeemtmedfaeafPeta 142
                    ++Y + v+ + l d+ +++  +l++ +++      + +++++++e+++v    +   +e k++i+ l++el++l+ l++ +++  +++ + + e+ 
     EFC35292.1 232 KFYDNYVNIKRLMDQQKTNIAELNTRIESysdrlkEIQKTNIEKESEQVDYGLQRLYSEKKDEIKRLTQELDALNLLIKKTQFSRDELLKKQKELD 327
                    56777777777777777777777666666664443334599**********************************************998876665 PP

                    X CS
  Mt_ATP-synt_D 143 l 143
                     
     EFC35292.1 328 S 328
                    5 PP

>> DUF4724  Domain of unknown function (DUF4724)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.2   6.5e-05      0.15      20      78 ..     236     294 ..     231     304 .. 0.75
   2 ?   -1.8   0.1         2   4.5e+03      74      86 ..     321     334 ..     297     344 .. 0.52

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6.5e-05
     DUF4724  20 nyvkvkPlfvqsktnlvtvas..sstsdhtssldskyvdvvsdqiflslspkgresekpke 78 
                 nyv +k l+ q ktn++   +   s sd    + + ++++ s+q+ + l      sek++e
  EFC35292.1 236 NYVNIKRLMDQQKTNIAELNTriESYSDRLKEIQKTNIEKESEQVDYGLQR--LYSEKKDE 294
                 9***************98777224667999999999999999996554433..34444443 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2
     DUF4724  74 ekpke.ekskekql 86 
                 +k+ke ++++ekq+
  EFC35292.1 321 KKQKElDSEEEKQI 334
                 22333123333333 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   8.2   5.3e-05      0.12      10     128 ..     194     305 ..     185     312 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 5.3e-05
                 CCCEEEEE-CCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHH.H CS
   Fib_alpha  10 eefgslCPtgCglqdlllkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirv.L 107
                 + +++lCP  C+  +      ++++++ ++ +n ++++ +++ + ++  ++ik  + +++++ ++ ++ i+++s++l+ ei+  k +i ++ +++ + L
  EFC35292.1 194 KAINNLCPVSCEYFE-----TNTFDETWNRYNNVIRKVMEESIKFYDNYVNIKRLMDQQKTNIAELNTRIESYSDRLK-EIQ--KTNIEKESEQVDYgL 284
                 567889999998544.....47899999999999999999************************99************.544..56777777777655* PP

                 HHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha 108 qnvlesneqkiqkLeqdidqk 128
                 q ++++++ +i++L q+ d++
  EFC35292.1 285 QRLYSEKKDEIKRLTQELDAL 305
                 ****************99876 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       0.8   1.8e+03     197     223 ..     124     156 ..      80     204 .. 0.52
   2 ?   10.3  10.1   0.00017      0.39     147     251 ..     210     328 ..     186     357 .. 0.55

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.8
  Exonuc_VII_L 197 erleralkkqlkkkrerleelkerl.k.....e 223
                   + +++a++ ql+ +++r+ +l++++ +     +
    EFC35292.1 124 YTVNKAIELQLQGAKSRWLRLAQQTaSflkfcS 156
                   344555555555555555555544422443331 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00017
  Exonuc_VII_L 147 eqleelerrlekaikrlleekkqrlekl..asrlk.speellerkrqrldeleerleralkkqlkkkrerleelkerl.k...ekleekkerlkklk 236
                   ++++e+ +r+++ i++ +ee+ +  +++   +rl  ++++ +++ + r++++++rl++ +k++++k++e+++   +rl +   +++++ +++l    
    EFC35292.1 210 NTFDETWNRYNNVIRKVMEESIKFYDNYvnIKRLMdQQKTNIAELNTRIESYSDRLKEIQKTNIEKESEQVDYGLQRLySekkDEIKRLTQEL---- 302
                   455666666666666666555555554432234432666666666777777777777766666777777777666666443333333333333.... PP

  Exonuc_VII_L 237 erle..............lleekkerlee 251
                      +              +l +k+++l++
    EFC35292.1 303 ---DalnllikktqfsrdELLKKQKELDS 328
                   ...22222222222222222223333322 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       6.2   1.4e+04     100     114 ..     214     228 ..     212     230 .. 0.82
   2 ?    8.4  17.6    0.0014         3       9     101 ..     242     333 ..     240     346 .. 0.65

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 6.2
      APG6_N 100 rfwreynelqlelle 114
                 + w++yn+  ++++e
  EFC35292.1 214 ETWNRYNNVIRKVME 228
                 789999999888886 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0014
      APG6_N   9 lLleeldkqleqaekerdaYeeflkklkkekkeeek......qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerf 101
                  L+++ ++ +++++  +++Y++ lk+++k++ e+e+              ++ +++ ++e ++l +eL++l    ++ +  + +l ++ ++l+ eee+ 
  EFC35292.1 242 RLMDQQKTNIAELNTRIESYSDRLKEIQKTNIEKESeqvdygL-------QRLYSEKKDEIKRLTQELDALNLLIKKTQFSRDELLKKQKELDSEEEKQ 333
                 699***************************7777644445541.......4444444555555555555555555555555555555555555555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (413 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2290  (0.127726); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.69u 0.36s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2257.89
//
Query:       EFC35293.1  [L=103]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0056   17.1   8.2       0.12   12.9   0.6    3.1  3  LRR_4     Leucine Rich repeats (2 copies)
     0.0086   16.1   1.0        1.8    8.8   0.3    3.3  3  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
      0.083   13.3   2.0        2.2    8.7   0.4    2.3  2  CLU_N     Mitochondrial function, CLU-N-term


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.6   1.9e-05      0.12       1      28 [.       2      33 ..       2      42 .. 0.84
   2 !    7.6   0.3    0.0009       5.4       1      33 [.      28      62 ..      28      72 .. 0.72
   3 !    5.8   1.3    0.0033        20       2      30 ..      53      84 ..      52      93 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.9e-05
                SS--EEE--.SS---E-S-HH..H.-TT--EE CS
       LRR_4  1 pnLevLdLs.nNqltdiplle..k.lpnLkeL 28
                ++L++Ld+s nN+    pl e  + ++nLkeL
  EFC35293.1  2 TQLTNLDIScNNKFNGTPLAEiiSrMTNLKEL 33
                68***********999888334455*****99 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0009
                SS--EEE--SS---E-S-HH..H-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnNqltdiplle..klpnLkeLdLsgN 33
                +nL++L ++   l   +ll+   +++L++Ld+ g 
  EFC35293.1 28 TNLKELAFRFSGLDREGLLWilEMKQLTSLDIYGH 62
                67888888855788877744545********9664 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0033
                S--EEE--SS---E-S-....HHH-TT--EEE- CS
       LRR_4  2 nLevLdLsnNqltdipl....leklpnLkeLdL 30
                +L++Ld+ + +l d +      ++l++L +L++
  EFC35293.1 53 QLTSLDIYG-HLFDSNVeeliYNNLKQLVKLNI 84
                799999997.67765554643336999999998 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.3    0.0003       1.8       3      14 ..       2      13 ..       1      18 [. 0.84
   2 ?    3.3   0.0     0.018   1.1e+02       3      20 ..      28      45 ..      26      46 .. 0.89
   3 ?    0.1   0.0      0.18   1.1e+03       5      10 ..      54      59 ..      51      64 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0003
       LRR_6  3 thLteLdLsgNd 14
                t Lt Ld+s+N+
  EFC35293.1  2 TQLTNLDISCNN 13
                579********8 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.018
       LRR_6  3 thLteLdLsgNdIgDeGa 20
                t+L+eL  ++ +++ eG+
  EFC35293.1 28 TNLKELAFRFSGLDREGL 45
                89********99999997 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.18
       LRR_6  5 LteLdL 10
                Lt+Ld+
  EFC35293.1 54 LTSLDI 59
                99**97 PP

>> CLU_N  Mitochondrial function, CLU-N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.1    0.0096        57      20      39 ..       3      23 ..       1      38 [. 0.75
   2 ?    8.7   0.4   0.00037       2.2      15      62 ..      48      88 ..      42      92 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.0096
       CLU_N 20 ylTnyhLkyeng.ngerlnef 39
                +lTn ++  +n+ ng+ l e 
  EFC35293.1  3 QLTNLDISCNNKfNGTPLAEI 23
                89*****99988888877664 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00037
       CLU_N 15 lpstkylTnyhLkyengngerlnefvtlseiieeedvdelkLelkekp 62
                + ++k+lT+ ++ y    g  ++   + +e+i ++ ++ +kL++kekp
  EFC35293.1 48 ILEMKQLTSLDI-Y----GHLFDS--NVEELIYNNLKQLVKLNIKEKP 88
                567899999999.4....356665..56799999999*********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      426  (0.0237604); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.32s 00:00:00.80 Elapsed: 00:00:00.50
# Mc/sec: 615.13
//
Query:       EFC35294.1  [L=427]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (427 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       905  (0.0504769); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 2367.38
//
Query:       EFC35295.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-52  173.4  36.3    2.3e-08   34.4   0.2    8.8  8  Sel1      Sel1 repeat
    0.00027   21.5   4.2       0.21   12.3   0.2    4.3  5  TPR_16    Tetratricopeptide repeat
    0.00093   19.4  11.7        6.1    7.2   0.1    5.8  6  TPR_12    Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.015   15.2   1.3       0.99    9.4   0.6    2.8  3  Raptor_N  Raptor N-terminal CASPase like domain
      0.059   13.7   3.7       0.65   10.4   0.0    3.6  4  TPR_20    Tetratricopeptide repeat
       0.12   12.5   6.7       0.34   11.1   0.2    4.0  4  TPR_7     Tetratricopeptide repeat
       0.22   11.8   0.3       0.22   11.8   0.3    7.3  7  TPR_8     Tetratricopeptide repeat
       0.61    9.8  22.4        8.8    6.1   0.1    6.6  6  TPR_11    TPR repeat
        1.3    9.8  17.4         17    6.3   0.8    5.7  6  TPR_6     Tetratricopeptide repeat
        1.3    9.3  32.7       0.38   11.0   0.3    8.4 10  TPR_2     Tetratricopeptide repeat
        2.2    8.4  18.3         10    6.3   0.3    5.5  5  MIT       MIT (microtubule interacting and transport) domain


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0     3e-05     0.048       5      37 ..       4      34 ..       1      35 [. 0.94
   2 !   26.0   0.0   6.2e-09     1e-05       2      38 .]      37      71 ..      36      71 .. 0.94
   3 !   28.5   0.4     1e-09   1.7e-06       1      38 []      72     107 ..      72     107 .. 0.94
   4 !   34.4   0.2   1.4e-11   2.3e-08       3      38 .]     110     143 ..     110     143 .. 0.98
   5 !   31.4   0.0   1.3e-10   2.1e-07       2      37 ..     145     178 ..     144     179 .. 0.90
   6 !   19.3   0.5   8.4e-07    0.0014       1      37 [.     180     214 ..     180     215 .. 0.93
   7 !   27.5   0.9   2.2e-09   3.6e-06       1      34 [.     216     247 ..     216     251 .. 0.91
   8 !   10.3   3.6   0.00056      0.91       3      36 ..     254     281 ..     252     281 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3e-05
        Sel1  5 yrLGmfylylnGlgvpkDpekAiewyekAAeqG 37
                y L    +y++Glgvp   ek ++++  +A++G
  EFC35295.1  4 YYLS--HMYQKGLGVPISNEKSLQLLYESASHG 34
                9999..999***********************9 PP

  == domain 2  score: 26.0 bits;  conditional E-value: 6.2e-09
        Sel1  2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                +++  LG  + y nG g+++  ekA+ew ekA eq++
  EFC35295.1 37 HSQLHLG--LRYKNGEGIEQSNEKAFEWIEKAVEQDY 71
                68999**..*************************985 PP

  == domain 3  score: 28.5 bits;  conditional E-value: 1e-09
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a A++ LG   lyl+G+g+ + ++kA e+++kAA+q++
  EFC35295.1  72 AQAQNHLG--ILYLKGKGIYQSYDKACECFQKAANQNN 107
                 68******..777***********************86 PP

  == domain 4  score: 34.4 bits;  conditional E-value: 1.4e-11
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 A+y+LG  + y nG+g+++ +ekA+e+++k+A+q++
  EFC35295.1 110 AQYNLG--LRYKNGQGIEQSYEKAFEFFQKSANQDH 143
                 9*****..**************************98 PP

  == domain 5  score: 31.4 bits;  conditional E-value: 1.3e-10
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                  A+  LG   ++++G+gv++  ekA+ew+ek+A qG
  EFC35295.1 145 QAQTELG--IMFYHGQGVEQSLEKAFEWFEKSAVQG 178
                 59*****..7778*******************9776 PP

  == domain 6  score: 19.3 bits;  conditional E-value: 8.4e-07
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 a A+  LG  +ly +G g++  +ekA ew +k+A qG
  EFC35295.1 180 AQAQSYLG--LLYAKGHGIKLSYEKACEWCQKSAIQG 214
                 679*****..777*********************887 PP

  == domain 7  score: 27.5 bits;  conditional E-value: 2.2e-09
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAA 34 
                 +eA++ LG   ly+ G+gv k +e A++w+e+AA
  EFC35295.1 216 PEAQFLLG--NLYYCGKGVAKSKENAFYWMEMAA 247
                 79******..666********************9 PP

  == domain 8  score: 10.3 bits;  conditional E-value: 0.00056
        Sel1   3 AmyrLGmfylylnGlgvpkD.pekAiewyekAAeq 36 
                 A+++LG +y  +       +  ekA+ wy kAA+q
  EFC35295.1 254 AQFMLGRMY--ERE-----NlMEKALDWYLKAANQ 281
                 888888666..333.....44889*********97 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.044        72      18      47 ..      58      85 ..      57     108 .. 0.76
   2 ?    2.7   0.0      0.12     2e+02      17      61 ..     129     175 ..     122     185 .. 0.83
   3 ?    0.7   0.1      0.55   8.9e+02      18      45 ..     166     191 ..     158     193 .. 0.73
   4 ?   -1.2   0.0       2.1   3.4e+03      34      45 ..     216     227 ..     214     230 .. 0.89
   5 !   12.3   0.2   0.00013      0.21      35      61 ..     253     279 ..     246     288 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.044
      TPR_16 18 aaleaalkrdpssPdaaeAllllgdaalrq 47
                +a+e+  k+   + d a+A+++lg ++l+ 
  EFC35295.1 58 KAFEWIEKAV--EQDYAQAQNHLGILYLKG 85
                6777777777..4779********999976 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.12
      TPR_16  17 aaaleaalkrdpssPdaaeAllllgdaalrq....grlaeAaalyraal 61 
                 ++a+e + k++    d+ +A+ +lg ++++     + l++A +++++ +
  EFC35295.1 129 EKAFEFFQKSA--NQDHIQAQTELGIMFYHGqgveQSLEKAFEWFEKSA 175
                 67888888888..5889999*********99999999999999999866 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.55
      TPR_16  18 aaleaalkrdpssPdaaeAllllgdaal 45 
                 +a+e++ k++      a+A+ +lg++++
  EFC35295.1 166 KAFEWFEKSAV--QGYAQAQSYLGLLYA 191
                 67777777775..347778877877776 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 2.1
      TPR_16  34 aeAllllgdaal 45 
                 +eA++llg++++
  EFC35295.1 216 PEAQFLLGNLYY 227
                 689*****9987 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 0.00013
      TPR_16  35 eAllllgdaalrqgrlaeAaalyraal 61 
                 +A++ lg+++ r + +++A+++y++a+
  EFC35295.1 253 QAQFMLGRMYERENLMEKALDWYLKAA 279
                 8************************97 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0      0.06        98      27      56 ..      57      83 ..      47      87 .. 0.69
   2 ?    3.9   0.1     0.041        68      19      33 ..      92     106 ..      90     117 .. 0.85
   3 !    7.2   0.1    0.0037       6.1      21      58 ..     123     158 ..     109     175 .. 0.72
   4 ?    1.0   0.1      0.34   5.5e+02      26      36 ..     164     174 ..     160     194 .. 0.50
   5 ?   -1.5   0.0         2   3.3e+03      19      29 ..     200     210 ..     199     213 .. 0.84
   6 !    7.2   0.4    0.0038       6.1      47      72 ..     254     279 ..     250     288 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.06
      TPR_12 27 ekaleiarrllGpdhpltattlrnLgrlyr 56
                eka e ++++ +    ++a++++ Lg+ly+
  EFC35295.1 57 EKAFEWIEKAVEQ---DYAQAQNHLGILYL 83
                6777777666333...36888888888885 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.041
      TPR_12  19 ydeAlellekaleia 33 
                 yd+A+e+++ka ++ 
  EFC35295.1  92 YDKACECFQKAANQN 106
                 9**********8865 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.0037
      TPR_12  21 eAlellekaleiarrllGpdhpltattlrnLgrl.yral 58 
                   ++ +eka e ++++ + dh   ++++  Lg++ y+ +
  EFC35295.1 123 GIEQSYEKAFEFFQKSANQDH---IQAQTELGIMfYHGQ 158
                 678889999999999966666...889999999933454 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.34
      TPR_12  26 lekaleiarrl 36 
                 leka e ++++
  EFC35295.1 164 LEKAFEWFEKS 174
                 45555555444 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 2
      TPR_12  19 ydeAlelleka 29 
                 y++A+e+++k+
  EFC35295.1 200 YEKACEWCQKS 210
                 89999999987 PP

  == domain 6  score: 7.2 bits;  conditional E-value: 0.0038
      TPR_12  47 tlrnLgrlyralgryeeAlelleeal 72 
                 +++ Lgr+y++ +  e+Al+++ +a 
  EFC35295.1 254 AQFMLGRMYERENLMEKALDWYLKAA 279
                 56677777777777777777777764 PP

>> Raptor_N  Raptor N-terminal CASPase like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1      0.39   6.4e+02      59     114 ..      51     105 ..      20     115 .. 0.71
   2 ?    9.4   0.6    0.0006      0.99      50     112 ..     111     176 ..      52     185 .. 0.75
   3 ?    3.2   0.0     0.049        80      89     108 ..     225     244 ..     196     258 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.39
    Raptor_N  59 rykqlldptvedvkklcqslrrnakdervlfHYnGhgvprptengeiwvfdksytq 114
                  ++q+ ++ +e ++k++++  ++a++   +++  G g+  +  ++ + +f k  +q
  EFC35295.1  51 GIEQSNEKAFEWIEKAVEQDYAQAQNHLGILYLKGKGIY-QSYDKACECFQKAANQ 105
                 567777778888888888888888888888888888877.5555556666666655 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0006
    Raptor_N  50 qyes.lqlra..rykqlldptvedvkklcqslrrnakdervlfHYnGhgvprptengeiwvfdksy 112
                 qy+  l  ++   ++q+ ++ +e ++k  ++   +a++e  +++Y G+gv++  e++  w+     
  EFC35295.1 111 QYNLgLRYKNgqGIEQSYEKAFEFFQKSANQDHIQAQTELGIMFYHGQGVEQSLEKAFEWFEKSAV 176
                 444443333334999999999999***99**********************888877666655555 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.049
    Raptor_N  89 fHYnGhgvprptengeiwvf 108
                 ++Y+G gv +  en+  w+ 
  EFC35295.1 225 LYYCGKGVAKSKENAFYWME 244
                 89*******99999988875 PP

>> TPR_20  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.4   2.3e+03      25      63 ..      39      77 ..      36      84 .. 0.66
   2 ?   10.4   0.0    0.0004      0.65      16      64 ..     102     150 ..      93     156 .. 0.90
   3 ?    6.3   0.0    0.0075        12      17      53 ..     139     175 ..     136     191 .. 0.88
   4 ?   -0.2   0.2      0.81   1.3e+03      22      54 ..     252     284 ..     232     294 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.4
      TPR_20 25 rldlAlallaagryeeAleqLleilkrdrkweddaarkq 63
                +l l l +  ++  e++ e+ +e++++  + +  +a+++
  EFC35295.1 39 QLHLGLRYKNGEGIEQSNEKAFEWIEKAVEQDYAQAQNH 77
                566666666667777777777777776666666666555 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.0004
      TPR_20  16 aanpddldarldlAlallaagryeeAleqLleilkrdrkweddaarkql 64 
                 aan ++  a+++l l +  ++  e++ e+ +e++++  + +  +a+++l
  EFC35295.1 102 AANQNNKCAQYNLGLRYKNGQGIEQSYEKAFEFFQKSANQDHIQAQTEL 150
                 7889999*******************************99988888877 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0075
      TPR_20  17 anpddldarldlAlallaagryeeAleqLleilkrdr 53 
                 an d ++a+ +l    ++++ +e++le+ +e++++  
  EFC35295.1 139 ANQDHIQAQTELGIMFYHGQGVEQSLEKAFEWFEKSA 175
                 788999**************************99865 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.81
      TPR_20  22 ldarldlAlallaagryeeAleqLleilkrdrk 54 
                  +a++ l + +  ++  e+Al+  l+   + +k
  EFC35295.1 252 TQAQFMLGRMYERENLMEKALDWYLKAANQLSK 284
                 689999999999999999999877766555544 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.12   1.9e+02      15      27 ..      92     102 ..      88     108 .. 0.87
   2 ?   -2.5   0.0       4.4   7.1e+03      15      25 ..     128     138 ..     126     141 .. 0.81
   3 ?   -2.2   0.1       3.5   5.7e+03      15      24 ..     200     209 ..     200     213 .. 0.85
   4 ?   11.1   0.2   0.00021      0.34       4      31 ..     257     285 ..     256     289 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.12
       TPR_7  15 yeeAielyeqsLa 27 
                 y++A e++++  a
  EFC35295.1  92 YDKACECFQK--A 102
                 9********9..4 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 4.4
       TPR_7  15 yeeAielyeqs 25 
                 ye+A e++++s
  EFC35295.1 128 YEKAFEFFQKS 138
                 88999999885 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 3.5
       TPR_7  15 yeeAielyeq 24 
                 ye+A e +++
  EFC35295.1 200 YEKACEWCQK 209
                 8999999998 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00021
       TPR_7   4 nLarlysrlGdyeeAielyeqsL.altkd 31 
                  L+r+y+r++ +e+A++ y ++  +l kd
  EFC35295.1 257 MLGRMYERENLMEKALDWYLKAAnQLSKD 285
                 59*******************87777766 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.1     0.057        93      17      31 ..      56      70 ..      53      73 .. 0.86
   2 ?    4.4   1.5     0.032        52      16      32 ..      91     107 ..      72     109 .. 0.84
   3 ?    2.1   0.1      0.18   2.9e+02      16      27 ..     127     138 ..     124     142 .. 0.82
   4 ?    0.7   0.1      0.49     8e+02      17      26 ..     164     173 ..     161     175 .. 0.74
   5 ?    0.6   0.1      0.54   8.8e+02      23      32 ..     199     208 ..     197     210 .. 0.67
   6 ?   -0.9   0.0       1.6   2.7e+03       2      11 ..     217     226 ..     216     227 .. 0.87
   7 ?   11.8   0.3   0.00014      0.22       2      27 ..     253     278 ..     252     280 .. 0.94

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.057
                HHHHHHHHHHHHHHH CS
       TPR_8 17 yeeAkeyyekaleld 31
                 e+A e++eka+e d
  EFC35295.1 56 NEKAFEWIEKAVEQD 70
                69**********966 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.032
                 -HHHHHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekaleldp 32 
                  y++A e+++ka   + 
  EFC35295.1  91 SYDKACECFQKAANQNN 107
                 69**********87665 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.18
                 -HHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyeka 27 
                  ye+A e+++k 
  EFC35295.1 127 SYEKAFEFFQKS 138
                 699999999986 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.49
                 HHHHHHHHHH CS
       TPR_8  17 yeeAkeyyek 26 
                 +e+A e++ek
  EFC35295.1 164 LEKAFEWFEK 173
                 6888888888 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.54
                 HHHHHHHHHH CS
       TPR_8  23 yyekaleldp 32 
                 +yeka+e+ +
  EFC35295.1 199 SYEKACEWCQ 208
                 6788887754 PP

  == domain 6  score: -0.9 bits;  conditional E-value: 1.6
                 CHHHHHHHHH CS
       TPR_8   2 eayynlgsiy 11 
                 ea ++lg++y
  EFC35295.1 217 EAQFLLGNLY 226
                 7899*****9 PP

  == domain 7  score: 11.8 bits;  conditional E-value: 0.00014
                 CHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyeka 27 
                 +a ++lg+ y+  + +e+A  +y ka
  EFC35295.1 253 QAQFMLGRMYERENLMEKALDWYLKA 278
                 689**********************9 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.1    0.0054       8.8      24      40 ..      68      84 ..      53      85 .. 0.83
   2 ?    6.0   1.3    0.0058       9.5       9      36 ..      91     116 ..      90     121 .. 0.73
   3 ?   -2.8   0.0       3.4   5.5e+03      16      23 ..     127     134 ..     126     143 .. 0.61
   4 ?    0.9   0.5      0.23   3.8e+02      27      40 ..     179     192 ..     177     193 .. 0.89
   5 ?    4.4   0.3     0.019        31      17      39 ..     200     227 ..     198     228 .. 0.67
   6 ?    3.2   0.1     0.044        72      10      23 ..     268     281 ..     259     287 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0054
      TPR_11 24 dPdnaeayynLGlayyk 40
                 +d+a a ++LG +y+k
  EFC35295.1 68 EQDYAQAQNHLGILYLK 84
                579**********9986 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0058
      TPR_11   9 kyeeAieaYkkAlkldPdnaeayynLGl 36 
                  y++A e+++kA + +++   a ynLGl
  EFC35295.1  91 SYDKACECFQKAANQNNK--CAQYNLGL 116
                 69**********976655..56788884 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 3.4
      TPR_11  16 aYkkAlkl 23 
                 +Y+kA ++
  EFC35295.1 127 SYEKAFEF 134
                 56666554 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.23
      TPR_11  27 naeayynLGlayyk 40 
                 +a a + LGl+y+k
  EFC35295.1 179 YAQAQSYLGLLYAK 192
                 79999******986 PP

  == domain 5  score: 4.4 bits;  conditional E-value: 0.019
      TPR_11  17 YkkAlkldPdn.....aeayynLGlayy 39 
                 Y+kA++ ++++     +ea + LG++yy
  EFC35295.1 200 YEKACEWCQKSaiqgiPEAQFLLGNLYY 227
                 555555555553333379********98 PP

  == domain 6  score: 3.2 bits;  conditional E-value: 0.044
      TPR_11  10 yeeAieaYkkAlkl 23 
                  e+A+ +Y kA + 
  EFC35295.1 268 MEKALDWYLKAANQ 281
                 59*********875 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0         4   6.4e+03      14      19 ..      69      74 ..      38      78 .. 0.55
   2 ?    6.3   0.1      0.01        17       6      28 ..      78     104 ..      73     106 .. 0.85
   3 ?    4.5   0.2      0.04        65       2      25 ..     110     137 ..     110     141 .. 0.82
   4 ?   -0.8   0.1         2   3.2e+03       2      13 ..     182     193 ..     177     205 .. 0.65
   5 ?    0.3   0.0      0.87   1.4e+03       1      11 [.     217     227 ..     217     237 .. 0.87
   6 ?    6.3   0.8      0.01        17       1      21 [.     253     273 ..     253     290 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 4
                HHHHHH CS
       TPR_6 14 gdtdkA 19
                +d+++A
  EFC35295.1 69 QDYAQA 74
                466666 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.01
                 HHHHHHHH....HHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrkl....gdtdkAlealerlik 28 
                 l+ +y+k+    + +dkA+e +++  +
  EFC35295.1  78 LGILYLKGkgiyQSYDKACECFQKAAN 104
                 788888877888899********9876 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.04
                 HHHHHHHHHHHH....HHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl....gdtdkAlealer 25 
                 A+y+l+l y+++    + ++kA e +++
  EFC35295.1 110 AQYNLGLRYKNGqgieQSYEKAFEFFQK 137
                 89********954787788888888886 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 2
                 HHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl 13 
                 A+ +l+l+y k+
  EFC35295.1 182 AQSYLGLLYAKG 193
                 444667777664 PP

  == domain 5  score: 0.3 bits;  conditional E-value: 0.87
                 HHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyr 11 
                 +A+++l+ +y+
  EFC35295.1 217 EAQFLLGNLYY 227
                 79******998 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.01
                 HHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrklgdtdkAle 21 
                 +A+++l++ y++ +  +kAl+
  EFC35295.1 253 QAQFMLGRMYERENLMEKALD 273
                 69**********889999987 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1      0.31   5.1e+02      18      31 ..      57      70 ..      55      73 .. 0.90
   2 ?   -1.4   0.0       2.1   3.5e+03       1      13 [.      72      84 ..      72      86 .. 0.82
   3 ?    9.2   0.1   0.00086       1.4      17      32 ..      92     107 ..      90     109 .. 0.87
   4 ?   -2.6   0.1       5.2   8.5e+03       3      11 ..     110     118 ..     110     120 .. 0.78
   5 ?    2.3   0.2      0.14   2.3e+02      17      28 ..     128     139 ..     125     142 .. 0.84
   6 ?   -0.3   0.0      0.99   1.6e+03      17      27 ..     164     174 ..     162     176 .. 0.85
   7 ?   -1.0   0.2       1.6   2.6e+03       1      13 [.     180     192 ..     180     193 .. 0.82
   8 ?    0.3   0.1      0.61   9.9e+02      17      27 ..     200     210 ..     199     212 .. 0.85
   9 ?    2.4   0.0      0.13   2.1e+02       1      12 [.     216     227 ..     216     230 .. 0.89
  10 ?   11.0   0.3   0.00023      0.38       3      28 ..     254     279 ..     252     285 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.31
       TPR_2 18 eeAleafekAleld 31
                e+A e+ ekA+e d
  EFC35295.1 57 EKAFEWIEKAVEQD 70
                79********9986 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.1
       TPR_2  1 aealynlGlayyk 13
                a+a + lG +y+k
  EFC35295.1 72 AQAQNHLGILYLK 84
                6788999999987 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00086
       TPR_2  17 yeeAleafekAleldP 32 
                 y++A e+f+kA   + 
  EFC35295.1  92 YDKACECFQKAANQNN 107
                 9**********98775 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 5.2
       TPR_2   3 alynlGlay 11 
                 a ynlGl y
  EFC35295.1 110 AQYNLGLRY 118
                 579999988 PP

  == domain 5  score: 2.3 bits;  conditional E-value: 0.14
       TPR_2  17 yeeAleafekAl 28 
                 ye+A e+f+k+ 
  EFC35295.1 128 YEKAFEFFQKSA 139
                 9********986 PP

  == domain 6  score: -0.3 bits;  conditional E-value: 0.99
       TPR_2  17 yeeAleafekA 27 
                 +e+A e+fek+
  EFC35295.1 164 LEKAFEWFEKS 174
                 58999***996 PP

  == domain 7  score: -1.0 bits;  conditional E-value: 1.6
       TPR_2   1 aealynlGlayyk 13 
                 a+a  +lGl+y+k
  EFC35295.1 180 AQAQSYLGLLYAK 192
                 5788999*99986 PP

  == domain 8  score: 0.3 bits;  conditional E-value: 0.61
       TPR_2  17 yeeAleafekA 27 
                 ye+A e+++k+
  EFC35295.1 200 YEKACEWCQKS 210
                 89999999986 PP

  == domain 9  score: 2.4 bits;  conditional E-value: 0.13
       TPR_2   1 aealynlGlayy 12 
                 +ea + lG++yy
  EFC35295.1 216 PEAQFLLGNLYY 227
                 6899*******9 PP

  == domain 10  score: 11.0 bits;  conditional E-value: 0.00023
       TPR_2   3 alynlGlayyklgdyeeAleafekAl 28 
                 a ++lG+ y++ +  e+Al+++ kA 
  EFC35295.1 254 AQFMLGRMYERENLMEKALDWYLKAA 279
                 789*********************97 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.2    0.0078        13       2      18 ..      57      73 ..      57      77 .. 0.90
   2 ?    6.3   0.3    0.0062        10      24      42 ..      89     107 ..      88     120 .. 0.76
   3 ?    1.7   0.1      0.17   2.8e+02      18      31 ..     126     139 ..     124     147 .. 0.72
   4 ?   -0.7   0.2      0.95   1.5e+03      22      39 ..     174     191 ..     171     211 .. 0.61
   5 ?    3.6   0.3     0.042        69      14      35 ..     262     283 ..     246     289 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0078
         MIT  2 dkAlelvkkAveeDnag 18
                +kA+e ++kAve+D a+
  EFC35295.1 57 EKAFEWIEKAVEQDYAQ 73
                69************987 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0062
         MIT  24 lelYkealelLlqalkekn 42 
                 ++ Y +a+e +++a +++n
  EFC35295.1  89 YQSYDKACECFQKAANQNN 107
                 6899999999999998544 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.17
         MIT  18 gnyeeAlelYkeal 31 
                 + ye+A+e ++++ 
  EFC35295.1 126 QSYEKAFEFFQKSA 139
                 56777777777765 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.95
         MIT  22 eAlelYkealelLlqalk 39 
                  A++ Y +a  +L ++ +
  EFC35295.1 174 SAVQGYAQAQSYLGLLYA 191
                 577777777777765554 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.042
         MIT  14 eDnagnyeeAlelYkealelLl 35 
                 +++++  e+Al++Y +a + L+
  EFC35295.1 262 YERENLMEKALDWYLKAANQLS 283
                 5677778899999999988886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       814  (0.0454013); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 1835.30
//
Query:       EFC35296.1  [L=350]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-23   83.1   1.3    2.2e-23   82.8   1.3    1.1  1  MFS_1           Major Facilitator Superfamily
    7.7e-11   41.5   5.1    1.1e-10   41.0   4.9    1.4  1  Sugar_tr        Sugar (and other) transporter
    1.1e-05   24.6   3.7     0.0023   16.8   0.1    2.3  2  MFS_1_like      MFS_1 like family
  ------ inclusion threshold ------
      0.025   13.0   0.0      0.043   12.2   0.0    1.2  1  MFS_3           Transmembrane secretion effector
      0.052   12.3   7.0      0.014   14.1   0.4    2.6  2  Folate_carrier  Reduced folate carrier
      0.054   13.6   0.4      0.054   13.6   0.4    2.8  3  CRA             Circumsporozoite-related antigen (CRA)
      0.075   13.5   0.8        1.7    9.1   0.4    2.2  2  RNA_pol_Rpc4    RNA polymerase III RPC4
       0.27   11.5   1.4       0.31   11.4   0.0    1.7  2  DUF4634         Domain of unknown function (DUF4634)
        4.4    5.8   6.9       0.31    9.6   2.3    1.3  2  Peptidase_S46   Peptidase S46
        4.6    7.4   5.9       0.77    9.9   1.1    2.2  2  ETRAMP          Malarial early transcribed membrane protein (


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.8   1.3   1.2e-26   2.2e-23      34     166 ..      84     232 ..      70     342 .. 0.72

  Alignments for each domain:
  == domain 1  score: 82.8 bits;  conditional E-value: 1.2e-26
       MFS_1  34 igllltlyalgaavaslplGrlsdrfGrrrvlllglllfalglllllfasslw.lllvlrvlqGlgagalfpagaaliadwfpkeergraigllsagfs 131
                 +gl++++y+l ++++s+++G +sd +Gr++vll+g ++ a+++l++ f s +  + + +r+l Gl   + + ++ +++ +++  ++++ra++l s++f+
  EFC35296.1  84 VGLVASAYFLSQFISSFFWGTISDSIGRKPVLLFGTFFGAICGLMFGF-SKWLwWACGCRFLFGLL-NGNLGVVKSYLGEITDSTNQARAFSLTSITFG 180
                 799***************************************888889.88777************.58889999************************ PP

       MFS_1 132 lGailgpllgglla.sslg.................Wravfyilaivsllafv 166
                 l+++lgp+lggl++  +                    r ++++  ++ + + +
  EFC35296.1 181 LASVLGPVLGGLFSrPH-QqypdfiilfpewiqdfvIRFPYVLPSFFIFCFYI 232
                 *************9333.35888888888877777733333333333333322 PP

>> Sugar_tr  Sugar (and other) transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.0   4.9   5.9e-14   1.1e-10      44     158 ..      80     194 ..      40     322 .. 0.75

  Alignments for each domain:
  == domain 1  score: 41.0 bits;  conditional E-value: 5.9e-14
                 ...HHHHHHHTHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHH-TTTTSS-TGGGGGHHHHHHHHHHHHHHHHHHHHTTS..-SCCH..HH CS
    Sugar_tr  44 ssvlsglivsiflvGaiiGslfagllgdrfGRkkslliaavlfvigavlqaaakgknsvevlivgRvlvGigvGlasvlvPmyisEiA..pkklR..ga 138
                    ++gl++s++++ ++i+s+f g+++d +GRk++ll+++++  i++++ +++k    ++  + +R+l G+  G   ++v  y++Ei+  + + R  + 
  EFC35296.1  80 YGYYVGLVASAYFLSQFISSFFWGTISDSIGRKPVLLFGTFFGAICGLMFGFSK---WLWWACGCRFLFGLLNGN-LGVVKSYLGEITdsTNQARafSL 174
                 44689*************************************************...88999*********9986.567778999*9944444442233 PP

                 HHHHHHHHHHHHHHHHHHHH CS
    Sugar_tr 139 lvslyqlaitfGilvaaifg 158
                     + la ++G +++  f 
  EFC35296.1 175 TSITFGLASVLGPVLGGLFS 194
                 34445566666666655555 PP

>> MFS_1_like  MFS_1 like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   1.3e-06    0.0023      35      80 ..      83     127 ..      80     133 .. 0.89
   2 !    8.5   1.0   0.00045      0.81     309     373 ..     131     193 ..     127     204 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.3e-06
  MFS_1_like  35 eigiitlilpltsilsppiwgvlaDrfgkrkkvvilslllsavlfl 80 
                  +g++ ++  l +++s+ +wg+++D +g rk+v+++++++ a++ l
  EFC35296.1  83 YVGLVASAYFLSQFISSFFWGTISDSIG-RKPVLLFGTFFGAICGL 127
                 599**********************998.699*******9999866 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00045
  MFS_1_like 309 iienawlvlpievLhgisfgllwaaaveyvskiapksleatgqgllsglyfglGralGsliGGll 373
                 + + +w++    +L g+  g l +++ +y  +i+    +a+  +l s++ fgl + lG ++GGl+
  EFC35296.1 131 FSKWLWWACGCRFLFGLLNGNL-GVVKSYLGEITDSTNQARAFSLTSIT-FGLASVLGPVLGGLF 193
                 55779***************99.999******************98765.*************87 PP

>> MFS_3  Transmembrane secretion effector
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   2.4e-05     0.043      46     161 ..      83     192 ..      79     195 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.4e-05
       MFS_3  46 mvAlvqaaatLPifllsilaGalaDnfdrRkvllavqlllalvsvlltvlaalgllspwlllaltlligiGaalndPaWqAsvgelvkrrdvpaAvaLn 144
                  v lv  a  L  f+ s + G ++D++ r+ vll +  + a+  ++   +  l        l   l  ++G        +  +ge+ +  +   A  L+
  EFC35296.1  83 YVGLVASAYFLSQFISSFFWGTISDSIGRKPVLLFGTFFGAICGLMFGFSKWLWWACGCRFLFGLLNGNLG------VVKSYLGEITDSTNQARAFSLT 175
                 68999999*******************************99999888777766544444444333333344......457899**************** PP

       MFS_3 145 svginiaRsvGPAlgGv 161
                 s+ + +a   GP lgG+
  EFC35296.1 176 SITFGLASVLGPVLGGL 192
                 ****************8 PP

>> Folate_carrier  Reduced folate carrier
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   1.5      0.87   1.6e+03     196     229 ..      37      62 ..      17      78 .. 0.44
   2 ?   14.1   0.4     8e-06     0.014      54     248 ..      95     307 ..      89     340 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.87
  Folate_carrier 196 askkdekseeeseeseeeenekeeeeeksseese 229
                     ++k++++se +  e+ee+        e++ +++e
      EFC35296.1  37 ETKDASSSEVNIVEEEEQ--------EQEIQKEE 62 
                     222222222222122222........22111111 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 8e-06
  Folate_carrier  54 ylallvpvflltdylrYkpvivlqalalivvwllllftksllalqvlevfYgvataaevaYysyiYslvdkekYqrvtsytRsavlvgkfvssvl 148
                     +++  ++   ++d +  kpv+++ ++ + ++ l++ f k l+++    + +g+      +  sy+    d ++  r+ s t  +  ++ +++ vl
      EFC35296.1  95 QFISSFFWGTISDSIGRKPVLLFGTFFGAICGLMFGFSKWLWWACGCRFLFGLLNGNLGVVKSYLGEITDSTNQARAFSLTSITFGLASVLGPVL 189
                     555556666799**********************************************9********************9999999999999999 PP

  Folate_carrier 149 aQllvs...................lakvsystlnyislasvvvalll.slfLprpkkslffkkk..eaaskkdekseeeseeseeeenekeeee 221
                     + l                      + ++ y         + +va++l  l L++++k+ +++++  +    k+ + +  +e+s+++  ++++e 
      EFC35296.1 190 GGLFSRphqqypdfiilfpewiqdfVIRFPYVLPSFFIFCFYIVAFVLgCLKLEEANKNTWYYRRfiA----KEIVDNIDKETSKTKLISSNNEL 280
                     98876677777777777766655544444444444445556666666623557888888888887331....22222222223333333334444 PP

  Folate_carrier 222 eksseesekkvlklllkelkeaysnkk 248
                     e+++ ++   v k +l+++k+ ++n k
      EFC35296.1 281 EEEQDQEPIIVKKSMLQKFKNKFNNFK 307
                     444444444444555555555555433 PP

>> CRA  Circumsporozoite-related antigen (CRA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   7.1       2.2   3.9e+03      55      89 ..      31      64 ..       9      68 .. 0.75
   2 ?   -1.0   0.0      0.98   1.7e+03      94     106 ..     175     187 ..     169     192 .. 0.83
   3 ?   13.6   0.4     3e-05     0.054       6      73 ..     224     290 ..     221     325 .. 0.64

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.2
         CRA 55 aeekedeneedridvlkLikelekKeeeliivnKk 89
                 eek++e +++ +  +++++e+ ++e+e+++ +Kk
  EFC35296.1 31 DEEKDQETKDASSSEVNIVEEE-EQEQEIQKEEKK 64
                3566799999999899998776.567888887776 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.98
         CRA  94 ksatfglatiigl 106
                  s+tfgla+++g 
  EFC35296.1 175 TSITFGLASVLGP 187
                 589******9975 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 3e-05
         CRA   6 slfviilllvv.ycdevkGkkknngkkdvwksrftkkk.gkykknekevekaeekedeneedridvlkLi 73 
                 s f+i ++ +v ++ +    ++   k+  +  rf++k    +  +e++  k +  ++e ee++     +i
  EFC35296.1 224 S-FFIFCFYIVaFVLGCLKLEEA-NKNTWYYRRFIAKEiVDNIDKETSKTKLISSNNELEEEQD-QEPII 290
                 4.5666*****999887766644.699999999**99874444445555555555544444443.22222 PP

>> RNA_pol_Rpc4  RNA polymerase III RPC4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.4   0.00095       1.7      22      82 ..      24      73 ..       8     101 .. 0.54
   2 ?    2.6   0.0     0.094   1.7e+02       5      19 ..     214     265 ..     212     312 .. 0.60

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00095
  RNA_pol_Rpc4 22 saaeddkseaesqsaekakaeeeskaekasgaeaeekkskkksskkkkkkkskalklkslp 82
                  ++ +d+++e           e+++++++as++e +  ++++++++ +k++k++++k++ lp
    EFC35296.1 24 EEVNDVADE-----------EKDQETKDASSSEVNIVEEEEQEQEIQKEEKKTPQKVTPLP 73
                  333333333...........33333333333344444444444444444444444444444 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.094
  RNA_pol_Rpc4   5 ylfQfPpllPslkq.....................................k 19 
                   ++++fP +lPs+                                       +
    EFC35296.1 214 FVIRFPYVLPSFFIfcfyivafvlgclkleeankntwyyrrfiakeivdniD 265
                   7899*******98788888888888888877777777666666554433221 PP

>> DUF4634  Domain of unknown function (DUF4634)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.3       3.5   6.3e+03      76      86 ..      44      54 ..      21      74 .. 0.50
   2 ?   11.4   0.0   0.00017      0.31      54     123 ..     252     323 ..     244     329 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 3.5
     DUF4634 76 ttisleterad 86
                + ++   e+++
  EFC35296.1 44 SEVNIVEEEEQ 54
                33222222222 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00017
     DUF4634  54 ysifesedrlnrldkevteavettisleteradhqkpvtvkpvtmetqsPdlndavs..slqsPvslllswv 123
                 y  f +++ ++++dke+ ++     + e e++++q+p+ vk  +++    + n+  s   l sP++ll  + 
  EFC35296.1 252 YRRFIAKEIVDNIDKETSKTKLISSNNELEEEQDQEPIIVKKSMLQKFKNKFNNFKSheMLSSPIPLLTCFL 323
                 666778888999****999999999999999**********99999999999987662269*****987654 PP

>> Peptidase_S46  Peptidase S46
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   2.3   0.00017      0.31      88     162 ..       6      80 ..       4      87 .. 0.82
   2 ?   -3.7   0.2       1.9   3.4e+03     443     448 ..     280     285 ..     251     309 .. 0.37

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00017
                    -SSGGGSBE-TT--EEEEEEEEE-HHHHTTTTTTSS-CHHHHHHHHHHHHHHHHHS---TT-EEEEEEEGGGTEE CS
  Peptidase_S46  88 AksreeElpapglrvtvleritdVTkrvkaalkaeeeeeerakaieaelkalakeceeedglrcevasfygGneY 162
                    A+ +++E + p +r t le+++dV ++ k++ +++++++e++   e+e+++ +++ e+++ ++++  ++ +  eY
     EFC35296.1   6 AELKDDEDNSPMMRTTALEEVNDVADEEKDQETKDASSSEVNIVEEEEQEQEIQKEEKKTPQKVTPLPWENPTEY 80 
                    6678999999*********************99999999999998888888888888887777766666666666 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.9
                    HHHHS- CS
  Peptidase_S46 443 yreklk 448
                    + e+ +
     EFC35296.1 280 LEEEQD 285
                    111111 PP

>> ETRAMP  Malarial early transcribed membrane protein (ETRAMP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.3       2.6   4.7e+03      46      46 ..      48      48 ..      14      69 .. 0.54
   2 ?    9.9   1.1   0.00043      0.77       5      58 ..     220     274 ..     217     308 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.6
      ETRAMP 46 i 46
                i
  EFC35296.1 48 I 48
                1 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00043
      ETRAMP   5 kv.llffafLlavnlltpeslcdevnkkk..................ekakkaikkiddkiekkkkkkKliii 58 
                  v  +ff+f++ +  ++ ++l+ e+++k+                  e                ++k+K  +i
  EFC35296.1 220 YVlPSFFIFCFYIVAFVLGCLKLEEANKNtwyyrrfiakeivdnidkE----------------TSKTK--LI 274
                 55568*****************99998776766555555555444442................44444..22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1807  (0.100786); expected 358.6 (0.02)
Passed bias filter:                      790  (0.0440627); expected 358.6 (0.02)
Passed Vit filter:                       100  (0.00557756); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.72u 0.34s 00:00:01.06 Elapsed: 00:00:00.47
# Mc/sec: 2256.84
//
Query:       EFC35297.1  [L=238]
Description: hypothetical protein NAEGRDRAFT_54990, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.8e-20   72.8   0.0    4.5e-20   72.6   0.0    1.1  1  ADP_ribosyl_GH  ADP-ribosylglycohydrolase


Domain annotation for each model (and alignments):
>> ADP_ribosyl_GH  ADP-ribosylglycohydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.6   0.0   2.5e-24   4.5e-20       5     159 ..      65     238 .]      61     238 .] 0.81

  Alignments for each domain:
  == domain 1  score: 72.6 bits;  conditional E-value: 2.5e-24
                     HHHHHHHHHGGGTT--HH....HHHHHTSS--S-----STTTTTS-TT---HHHHHHHHHHHTEET.................TEE-HHH..... CS
  ADP_ribosyl_GH   5 GaavGDAlGlpvefwsyd....eirrrygelgetpdktgfghfglkpgewtddtqmallllesllea................ggldped..... 74 
                       avGDA+G+    w+ +    +i+++++++      ++ ++ + k + ++ddt  +l++l++l+++                +           
      EFC35297.1  65 LTAVGDAIGYRNGTWEFNfsgeRIHKELKDEF----GGKIANIDTKSWKVSDDTIFHLATLKTLTHKdlnqiltpklsigfkdE-----Gfmelv 150
                     579******76555555555579999998875....88889999**********************988877777777655553.....134444 PP

                     ..HHHHHHH.HHT....T--SS--HHHHHHHHHTTT.T-...-S-B...---BTTTGGG-HHHHHHTSS-HHHHHHHHHHHHHTTB-- CS
  ADP_ribosyl_GH  75 ..larrflaeWleepgdteprgignttrealrnlks.gepppeaganangsagngalmRaaplgllyagdpeeaaelaeeaarlTHnh 159
                       ++  +++e++ +++d+ +r +g+ +r++++ +k+  ++ +++  ++ +  g+g+ mRa+ +gl+++++++ ++++ +e++rlTHnh
      EFC35297.1 151 dkIMVVMVQEYVACWKDMGDRSPGKKCRDSINYIKQtRKNKWDSLNYDSRGGGCGGSMRAMSIGLAFHDNLDLLIAIGIESGRLTHNH 238
                     45555555556666667*****************997667778888889**************************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       464  (0.0258799); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.33s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1375.16
//
Query:       EFC35298.1  [L=141]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.055   12.6   1.5      0.059   12.5   1.5    1.2  1  SAP130_C  Histone deacetylase complex subunit SAP130 C-termin
       0.18   11.9   4.1       0.21   11.7   4.1    1.1  1  NST1      Salt tolerance down-regulator


Domain annotation for each model (and alignments):
>> SAP130_C  Histone deacetylase complex subunit SAP130 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   1.5   6.6e-06     0.059     184     224 ..       9      49 ..       1      91 [. 0.77

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 6.6e-06
    SAP130_C 184 apaltslanalsvpagdllpGasprkkprkqqhvisteese 224
                  +   ++ n+++ ++++l p a+ +kk rk++ +  t e++
  EFC35298.1   9 ETNTNTTNNNIGSSPTQLEPTATKKKKKRKKKTINPTSEGD 49 
                 3445567799***************************9998 PP

>> NST1  Salt tolerance down-regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   4.1   2.3e-05      0.21      11      76 ..       8      86 ..       3     115 .. 0.57

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.3e-05
        NST1 11 eqqqqqqdknevd.eksqvesskrkkkkkkkkk.........nrsnsnnqneesstslstsk...svaittssarsvkn 76
                +++++++ +n++  + +q e +++kkkkk+kkk         + s+s+++  ++  +l+ts+   + +i +s++++v++
  EFC35298.1  8 NETNTNTTNNNIGsSPTQLEPTATKKKKKRKKKtinptsegdGDSGSEKKRVKQLPPLQTSPkglDHVIDESTSNVVGT 86
                3444444444444044455777777777777777777766666666666666665555555411223455555555553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       885  (0.0493614); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.36u 0.24s 00:00:00.60 Elapsed: 00:00:00.40
# Mc/sec: 1069.20
//
Query:       EFC35299.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.065   13.5   4.0       0.11   12.7   4.0    1.4  1  DUF5041   Domain of unknown function (DUF5041)
        2.5    8.2  10.0       0.72    9.9   6.3    2.1  2  NYD-SP28  Sperm tail


Domain annotation for each model (and alignments):
>> DUF5041  Domain of unknown function (DUF5041)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   4.0   1.2e-05      0.11      14     110 ..      14     110 ..       4     140 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.2e-05
     DUF5041  14 frFdlsellkkeYnvevYvdeYkngkkidrvhefklGkniks..leevpeerreairkeeliaekkkeyelikelsiylrketDstavitisvPevaka 110
                  r  ls   +k Y+ ++ ++ Y++ kk+++ ++ ++ k ++s  l +vpee  e+i + ++++++++  + +k+  i    ++D       svP  +k+
  EFC35299.1  14 NREKLSSNYEKVYQ-DFRMERYEHEKKTNKKKQTRFEKEKRSllLGNVPEESDEEISRPKKVKKNNN-RNIVKSKVIENDDSSDESDNSASSVPPQKKS 110
                 55566666677776.899***********999999999988733589*********99888776655.4778887888777777766666677666544 PP

>> NYD-SP28  Sperm tail
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   6.3     8e-05      0.72       3      60 ..      13      70 ..      11      89 .. 0.90
   2 ?   -3.2   0.1         1     9e+03      22      35 ..     182     195 ..     167     205 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 8e-05
    NYD-SP28  3 dareeerrreeeelrqerkekleeeaksseekfeeinekWreilrknkpqeLrkelee 60
                 +re+   + e+  + +r e++e+e+k++++k  + +++ r++l  n+p+e ++e+  
  EFC35299.1 13 ANREKLSSNYEKVYQDFRMERYEHEKKTNKKKQTRFEKEKRSLLLGNVPEESDEEISR 70
                5788999999999**************************************9999975 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1
    NYD-SP28  22 ekleeeaksseekf 35 
                 + l +e++ss +k 
  EFC35299.1 182 NNLRNESSSSTKKK 195
                 45666666665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2718  (0.151598); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        95  (0.00529868); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.97u 0.34s 00:00:01.31 Elapsed: 00:00:00.52
# Mc/sec: 1911.45
//
Query:       EFC35300.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.052   12.9   0.3       0.07   12.5   0.3    1.2  1  30K_MP_C_Ter  C-Terminal of 30K viral movement proteins
      0.058   12.7   0.8      0.084   12.2   0.8    1.1  1  Peptidase_U4  Sporulation factor SpoIIGA


Domain annotation for each model (and alignments):
>> 30K_MP_C_Ter  C-Terminal of 30K viral movement proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.3   7.8e-06      0.07      15      55 ..      74     114 ..      64     128 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.8e-06
  30K_MP_C_Ter  15 vseeinqkrddykkklieneklrrregkgvkietetrssss 55 
                    s ei qkrdd  + +++ +++ r+e     +++et+s +s
    EFC35300.1  74 TSVEIIQKRDDISQSVLNSDQIIRKEDFREYVNSETKSNTS 114
                   588**************************9******99877 PP

>> Peptidase_U4  Sporulation factor SpoIIGA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.8   9.3e-06     0.084      89     160 ..      11      86 ..       6      90 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 9.3e-06
  Peptidase_U4  89 lllfylvsfllgGilfalsyll....lksknllvlllgalvaylllkllvkiikkkkkkekeiyeveielkgkkie 160
                   ++l+ l+s+ +gG++fa +  l    l  +++++ll++++v++ +  l + +i+ + + ++ +  vei  k   i+
    EFC35300.1  11 MALLNLISMSFGGLAFAYYIPLypicLFIHKISLLLFCIIVTFSFGPLDFVLIEFNSTSSQSVTSVEIIQKRDDIS 86 
                   678889**********9988777777445569**************9999999**************998877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       678  (0.0378158); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.32s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 927.28
//
Query:       EFC35301.1  [L=107]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-13   50.0  19.6      2e-13   50.0  19.6    1.7  2  Ifi-6-16      Interferon-induced 6-16 family
  ------ inclusion threshold ------
      0.053   12.9   0.0      0.071   12.5   0.0    1.2  1  2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, 


Domain annotation for each model (and alignments):
>> Ifi-6-16  Interferon-induced 6-16 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.9     0.047   4.2e+02      58      72 ..      31      45 ..      26      51 .. 0.57
   2 !   50.0  19.6   2.3e-17     2e-13       2      61 ..      43      97 ..      42     104 .. 0.96

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.047
    Ifi-6-16 58 GaaGlsaaatallgs 72
                G++G+++++++++g+
  EFC35301.1 31 GTVGAGTIGATVAGA 45
                555555555444444 PP

  == domain 2  score: 50.0 bits;  conditional E-value: 2.3e-17
    Ifi-6-16  2 ggvvavvaaPvvlsalGFtaaGiaagSlAAkmmSaaAianGGgVaaGslvAvlQSaGaaG 61
                +g+++ v +P+v s lGF+++G++ag++AA mmSaa     G+VaaGs+vA lQS+Ga+G
  EFC35301.1 43 AGATTYVGVPLVASSLGFGSGGVVAGTTAAGMMSAA-----GNVAAGSFVAGLQSVGATG 97
                688999******************************.....*****************99 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   7.9e-06     0.071      22      64 ..      13      55 ..       2      60 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.9e-06
                  CCHTTCCGSBS-GTTSEEEEES-SHHHHHHHHHHHHTT-EEEE CS
  2-Hacid_dh_C 22 ewksekallgkelsgktvGiiGlGrIGqavakrlkafgmkvia 64
                  + ++e+  ++++ s+  +G +G+G IG +va   + +g+ ++a
    EFC35301.1 13 KTQTETPPTQQQESNNLLGTVGAGTIGATVAGATTYVGVPLVA 55
                  33466677778889999**************999999988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (107 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.41u 0.30s 00:00:00.71 Elapsed: 00:00:00.45
# Mc/sec: 716.79
//
Query:       EFC35302.1  [L=220]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.7    8.1   6.2       0.73    9.9   0.3    2.6  3  DUF3568   Protein of unknown function (DUF3568)


Domain annotation for each model (and alignments):
>> DUF3568  Protein of unknown function (DUF3568)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1     0.055   9.9e+02      72     104 ..      23      56 ..      12      61 .. 0.63
   2 ?    9.9   0.3   4.1e-05      0.73      66     108 ..      60     102 ..      56     103 .. 0.93
   3 ?   -0.7   0.1     0.077   1.4e+03      56      79 ..     132     155 ..     123     169 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.055
     DUF3568  72 dsssatieakaaedktvf.iklekldknstkvsI 104
                 ++ +  ++ k  + k+v   +++k ++++t+++I
  EFC35302.1  23 NGEEILLHIKIPNRKNVIdLEIFKTKHQETQIRI 56 
                 5555555555555555545777788888888877 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 4.1e-05
     DUF3568  66 vvekskdsssatieakaaedktvfiklekldknstkvsIrvGs 108
                 + e+s +  +a++  k ++ ++ +++ +kl+k++tkv+ r G+
  EFC35302.1  60 FIEESLNRCDASYVKKIKTAENETVTGVKLSKDKTKVKLRLGI 102
                 678999999*******************************995 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.077
     DUF3568  56 kaiedlnvlsvvekskdsssatie 79 
                  +i + ++ ++ ++s+d  +++i+
  EFC35302.1 132 TTITNESQKQLENNSQDVDDTQID 155
                 566677777888888888887775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       844  (0.0470746); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.36s 00:00:00.97 Elapsed: 00:00:00.58
# Mc/sec: 1140.04
//
Query:       EFC35303.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.5e-39  131.1   8.1      3e-11   42.9   0.1    5.8  6  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.9   0.0   5.9e-14   1.1e-09       3      49 .]      26      72 ..      24      72 .. 0.97
   2 !   42.9   0.1   1.7e-15     3e-11       1      49 []      49      97 ..      49      97 .. 0.96
   3 !   30.5   0.1   1.2e-11   2.1e-07       4      45 ..      77     118 ..      74     122 .. 0.92
   4 !   25.8   0.0   3.6e-10   6.4e-06       5      49 .]     103     147 ..     102     147 .. 0.97
   5 !   23.8   0.0   1.5e-09   2.7e-05       7      47 ..     155     195 ..     150     196 .. 0.88
   6 !    6.7   0.4   0.00032       5.8      25      44 ..     196     220 ..     192     227 .. 0.77

  Alignments for each domain:
  == domain 1  score: 37.9 bits;  conditional E-value: 5.9e-14
     DUF4116  3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                E ++e+++ ng+al++l+++++ D  +v  Avk+ g +l+yase Lr
  EFC35303.1 26 ETMKELLEFNGYALEFLPNSFQDDESLVSIAVKSRGLSLKYASERLR 72
                889*****************************************998 PP

  == domain 2  score: 42.9 bits;  conditional E-value: 1.7e-15
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                D+ +v  avk+ g++lky+se+L+n+  iv  Av qn ++++yas eL+
  EFC35303.1 49 DESLVSIAVKSRGLSLKYASERLRNNPTIVDLAVSQNYYSFEYASRELK 97
                7788999****************************************97 PP

  == domain 3  score: 30.5 bits;  conditional E-value: 1.2e-11
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 iv  av++n ++++y+s eLknDk  +l+ v++ng  l+ ++
  EFC35303.1  77 IVDLAVSQNYYSFEYASRELKNDKMKILEYVERNGLLLEIVP 118
                 7778*******************************9998776 PP

  == domain 4  score: 25.8 bits;  conditional E-value: 3.6e-10
     DUF4116   5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +le+v++ng+ l+ ++  +k D +iv  A+ qn+ ++ +ase+++
  EFC35303.1 103 ILEYVERNGLLLEIVPGIFKEDLQIVQMAIAQNPLSIQFASEKFK 147
                 79***************************************9986 PP

  == domain 5  score: 23.8 bits;  conditional E-value: 1.5e-09
     DUF4116   7 eavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                  +++k g+ lk++s++L++D +i+l A k  g a+ y  ++
  EFC35303.1 155 PLIEKKGELLKFASNSLQSDSNIILTATKTFGLAILYSFKK 195
                 5799****************************999987665 PP

  == domain 6  score: 6.7 bits;  conditional E-value: 0.00032
     DUF4116  25 nDkeivlkAvkqngt.....alsya 44 
                  D e++l +vk+n+      +l+y+
  EFC35303.1 196 LDTELILDCVKINKLyenkqILNYV 220
                 599********99854666688887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       752  (0.0419432); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1863.64
//
Query:       EFC35304.1  [L=248]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (248 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       878  (0.0489709); expected 358.6 (0.02)
Passed bias filter:                      559  (0.0311785); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1540.98
//
Query:       EFC35305.1  [L=237]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1481  (0.0826036); expected 358.6 (0.02)
Passed bias filter:                      190  (0.0105974); expected 358.6 (0.02)
Passed Vit filter:                         9  (0.00050198); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 1352.28
//
Query:       EFC35306.1  [L=181]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       932  (0.0519828); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.40u 0.27s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 1310.03
//
Query:       EFC35307.1  [L=164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-10   39.7   5.2      1e-07   31.6   1.3    2.3  2  LRR_8     Leucine rich repeat
    8.8e-09   34.7   2.3     0.0076   16.2   0.1    4.5  4  LRR_6     Leucine Rich repeat
    1.6e-07   31.5  10.9    0.00032   21.0   3.1    3.5  3  LRR_4     Leucine Rich repeats (2 copies)
    8.2e-05   22.2   2.4    0.00038   20.0   1.9    1.9  2  LRR_9     Leucine-rich repeat
    8.7e-05   22.6   2.1        1.3    9.9   0.0    4.2  4  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.6   1.3   2.8e-11     1e-07       2      60 ..       3      61 ..       2      62 .. 0.97
   2 !   17.6   0.4   6.7e-07    0.0024       2      57 ..      51     107 ..      50     111 .. 0.96

  Alignments for each domain:
  == domain 1  score: 31.6 bits;  conditional E-value: 2.8e-11
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60
                +L++L+L++N +  l+    ++l+nL++L+L+n +++    + +s ++sLr L +  N+
  EFC35307.1  3 TLKTLILNDNPIGQLGAALISKLTNLRELNLTNTCMNDKGVEYISKMASLRDLQIGTNH 61
                79*****************************************************9998 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 6.7e-07
                 T-SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   2 nLtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 +L+ L++  N+ +t+l+    ++++nL+ L+    +++    + +++L sL++Ld +
  EFC35307.1  51 SLRDLQIGTNHmITKLGALYLSQMKNLQRLSVPATSINDQGVEFLVNLDSLQYLDAR 107
                 799***************************************************976 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.1   0.00016      0.59       4      23 ..       3      22 ..       1      23 [. 0.88
   2 !   16.2   0.1   2.1e-06    0.0076       2      24 .]      25      47 ..      24      47 .. 0.91
   3 ?    3.1   0.0     0.033   1.2e+02       4      23 ..      51      71 ..      48      72 .. 0.86
   4 ?    1.3   0.0      0.13   4.7e+02      14      23 ..      86      95 ..      74      96 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00016
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                +L++L L++N Ig  Ga  +
  EFC35307.1  3 TLKTLILNDNPIGQLGAALI 22
                9************9998766 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 2.1e-06
       LRR_6  2 nthLteLdLsgNdIgDeGaeaLa 24
                 t+L+eL+L+  +++D+G+e ++
  EFC35307.1 25 LTNLRELNLTNTCMNDKGVEYIS 47
                589****************9885 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.033
       LRR_6  4 hLteLdLsgNd.IgDeGaeaL 23
                +L+ L++  N+ I+  Ga  L
  EFC35307.1 51 SLRDLQIGTNHmITKLGALYL 71
                899**********99999877 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.13
       LRR_6 14 dIgDeGaeaL 23
                 I+D+G+e L
  EFC35307.1 86 SINDQGVEFL 95
                699****977 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   3.1     9e-08   0.00032       2      33 ..       3      35 ..       2      48 .. 0.87
   2 !   10.8   0.1   0.00015      0.54       2      30 ..      51      82 ..      50      90 .. 0.77
   3 ?    3.7   0.1     0.025        90      16      29 ..      92     105 ..      85     119 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 9e-08
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33
                 L++L L++N +  ++   ++kl+nL+eL+L  N
  EFC35307.1  3 TLKTLILNDNPIGQLGAalISKLTNLRELNL-TN 35
                69***************95557*********.55 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00015
                S--EEE--.SS---E-S-..HHH-TT--EEE- CS
       LRR_4  2 nLevLdLs.nNqltdipl..leklpnLkeLdL 30
                +L+ L ++ n ++t+++   l++++nL+ L++
  EFC35307.1 51 SLRDLQIGtNHMITKLGAlyLSQMKNLQRLSV 82
                688888885438******55558*******97 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.025
                 -S-HHH-TT--EEE CS
       LRR_4  16 iplleklpnLkeLd 29 
                 +++l +l++L++Ld
  EFC35307.1  92 VEFLVNLDSLQYLD 105
                 456889*******9 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   1.9   1.1e-07   0.00038      63     128 ..       1      65 [.       1      80 [. 0.90
   2 !    4.2   0.1    0.0074        27      90     127 ..      52      89 ..      47     115 .. 0.64

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1.1e-07
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 +k lktl+ln+n i +++  l   l nl+el ltn ++++ + ++ + ++ +l+ l + +n +++k
  EFC35307.1   1 MKTLKTLILNDNPIGQLGAALISKLTNLRELNLTNTCMNDKG-VEYISKMASLRDLQIGTNHMITK 65 
                 688***********************************9976.59999999999999988888776 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0074
       LRR_9  90 leelvl.tnnelqeladldPlaslkklellsllknpvtn 127
                 l+ l + tn ++++l+ l  l ++k+l+ ls+  +++ +
  EFC35307.1  52 LRDLQIgTNHMITKLGAL-YLSQMKNLQRLSVPATSIND 89 
                 555544156668888884.68999999998875555443 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.9   0.0   0.00035       1.3       2      23 .]       4      25 ..       3      25 .. 0.91
   2 !    8.0   0.0    0.0015       5.4       1      21 [.      27      47 ..      27      49 .. 0.81
   3 ?   -1.5   0.0         2   7.1e+03       1       6 [.      76      81 ..      65      90 .. 0.72
   4 ?    1.5   0.1      0.21   7.4e+02       1      12 [.     100     111 ..     100     163 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00035
       LRR_1  2 LrhLdLsnnpllglppnsfqnL 23
                L++L L++np+++l+++ +++L
  EFC35307.1  4 LKTLILNDNPIGQLGAALISKL 25
                9**************9998876 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0015
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                nLr+L+L+n +  +++ ++++
  EFC35307.1 27 NLRELNLTNTCMNDKGVEYIS 47
                9********998777777666 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 2
       LRR_1  1 nLrhLd 6 
                nL++L 
  EFC35307.1 76 NLQRLS 81
                566654 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.21
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld ++ pl
  EFC35307.1 100 SLQYLDARGLPL 111
                 588888766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       442  (0.0246528); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.34s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 924.19
//
Query:       EFC35308.1  [L=103]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.048   13.2   0.6      0.063   12.9   0.6    1.2  1  LOR       LURP-one-related
       0.19   10.2   1.6       0.21   10.1   1.6    1.1  1  Het-C     Heterokaryon incompatibility protein Het-C
        0.2   12.2   5.6       0.32   11.5   5.6    1.6  1  UPF0449   Uncharacterised protein family UPF0449
        0.3    8.6   8.5        1.8    6.0   0.1    2.0  2  DUF3584   Protein of unknown function (DUF3584)
       0.39   10.6   6.3       0.58   10.0   6.3    1.5  1  CHD5      CHD5-like protein


Domain annotation for each model (and alignments):
>> LOR  LURP-one-related
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.6   1.8e-05     0.063      50      91 ..      37      78 ..      30     101 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.8e-05
                TBTTEEEEE-TTS-EEEEEE--------EEEEEETT---GGG CS
         LOR 50 slsdelvLmDssGkvLltirrKklslhdrWevyrgesterkd 91
                + s+++++ D++G++L+ + rK l l +  +  ++e +e+k+
  EFC35308.1 37 NNSKKRSIEDLDGSKLVEMNRKLLKLSKDLKTENEELKESKK 78
                568899********************9997777777666655 PP

>> Het-C  Heterokaryon incompatibility protein Het-C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   1.6   5.9e-05      0.21     285     345 ..      25      87 ..      15     101 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 5.9e-05
       Het-C 285 qsevdeldaaleeaekss..ssssksalksllsklpgtgddlaeeaeelkakseaqeaenasa 345
                 qs+v  ld+ +++++k++  ++ + s+l ++ +kl + ++dl +e eelk++ +a e+en ++
  EFC35308.1  25 QSDVGYLDTFIKNNSKKRsiEDLDGSKLVEMNRKLLKLSKDLKTENEELKESKKALEKENLKQ 87 
                 89999*******999998444557899*****************************9999844 PP

>> UPF0449  Uncharacterised protein family UPF0449
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   5.6     9e-05      0.32      65      98 ..      50      83 ..       3      86 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 9e-05
     UPF0449 65 rtylelnerLeeakeeLkqkceeLktageeLeee 98
                 +++e+n++L + +++Lk + eeLk   + Le+e
  EFC35308.1 50 SKLVEMNRKLLKLSKDLKTENEELKESKKALEKE 83
                689**************************99975 PP

>> DUF3584  Protein of unknown function (DUF3584)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.1   0.00049       1.8     910     952 ..       4      46 ..       1      49 [. 0.87
   2 ?    4.7   4.8    0.0012       4.3     829     878 ..      50      99 ..      44     102 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.00049
     DUF3584 910 rerlsedvkkalerfkgvlkdksgsglaetweklreeestlsd 952
                     ++++++++e+f +v+ d+s  g ++t+ k ++++++++d
  EFC35308.1   4 STESQKEIEEKMENFSSVIPDQSDVGYLDTFIKNNSKKRSIED 46 
                 4567889***************************888887766 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0012
     DUF3584 829 saaeeleqeltrliedtklerkklekerkalekqldqldenlrklrdlls 878
                 s++ e++ +l +l++d+k+e+++l++ +kalek   + +++l  lr+++ 
  EFC35308.1  50 SKLVEMNRKLLKLSKDLKTENEELKESKKALEKENLKQKNLLLALRAMMD 99 
                 56778899999999999999999999999999999999999888999886 PP

>> CHD5  CHD5-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   6.3   0.00016      0.58      69     106 ..      54      91 ..       2      98 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00016
        CHD5  69 KlnRkldkleeeleklkkelsaskssfkkklkkvllvl 106
                  +nRkl kl+++l+++++el++sk++ +k   k + +l
  EFC35308.1  54 EMNRKLLKLSKDLKTENEELKESKKALEKENLKQKNLL 91 
                 58************************998755555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2250  (0.125495); expected 358.6 (0.02)
Passed bias filter:                      671  (0.0374254); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.53u 0.35s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 592.55
//
Query:       EFC35309.1  [L=160]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-06   27.0   0.0      7e-06   26.3   0.0    1.4  1  GST_N     Glutathione S-transferase, N-terminal domain
     0.0018   18.7   0.0     0.0038   17.6   0.0    1.6  1  GST_N_3   Glutathione S-transferase, N-terminal domain
  ------ inclusion threshold ------
      0.025   14.8   0.0      0.044   14.0   0.0    1.4  1  GST_C_3   Glutathione S-transferase, C-terminal domain
      0.096   13.0   0.0        0.2   12.0   0.0    1.5  1  GST_N_2   Glutathione S-transferase, N-terminal domain


Domain annotation for each model (and alignments):
>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.0   1.6e-09     7e-06       3      75 ..       6      81 ..       4      82 .. 0.89

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 1.6e-09
                EEEESSSTSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTT.....S-SSEEEETTEEEESHHHHHHHHH CS
       GST_N  3 ltlysirgsprahrirlllaakgveyevvpldfeageekspellklnpl.....gkvPaLedngkkltESraIleYia 75
                lt++s rg   ++ ir+ la  gv+y +v++ +    eks+ +++l +        +P  +d+   l++S  I++Y+ 
  EFC35309.1  6 LTYFSSRG--KSELIRIILADCGVDYDEVNVGVWHPTEKSDAFKQLVESktlafDSLPSYQDDQILLVQSSSIVRYLG 81
                89******..********************9987777777777776666666************************96 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   8.4e-07    0.0038      11      72 ..      16      85 ..       8      94 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 8.4e-07
                HHHHHHHHHHT--EEEE--...-TTTTHHHHHHH-.....TT--SSEEETTS-EEESHHHHHHHHHHHH- CS
     GST_N_3 11 rrvrlaLnekglpvevvev...tpgehdeellakn.....plgkvPvLeddgealtdSlaIidyLeelyp 72
                  +r++L  +g+++ +v+v   +p+e+++++++           +P  +dd+  l  S++I++yL ++++
  EFC35309.1 16 ELIRIILADCGVDYDEVNVgvwHPTEKSDAFKQLVesktlAFDSLPSYQDDQILLVQSSSIVRYLGKKFG 85
                568*************99944448889999999994444555568********************99987 PP

>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   9.9e-06     0.044      16      48 ..     127     160 .]     111     160 .] 0.75

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 9.9e-06
                 HHH..HHHHHHHHHHHHCHHHHHHHHHHCHGTSSS CS
     GST_C_3  16 eea..ekkkefleerlpkflkyfekvlkkkgggyl 48 
                 +e+  +k + +l+e+lpk l++fe++l+  g++yl
  EFC35309.1 127 NESieQKIQIILKEKLPKLLQFFERALE-GGKEYL 160
                 333668888999****************.666687 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   4.4e-05       0.2       8      69 ..      18      82 ..      15      83 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.4e-05
                HHHHHHHCT--EEEEEEH...-TTSHHHHHHHHCTTT.....SSSEEE-CTTEEEESHHHHHHHHHH CS
     GST_N_2  8 vlialalkglediisvvvlepkgfekseefprlnprg.....tVPvLwdkdgqvineSseIlrylet 69
                ++i la +g+++    v  + ++ eks+ f++l  +      ++P  +d d+  ++ Ss I+ryl++
  EFC35309.1 18 IRIILADCGVDYDEVNVGVW-HPTEKSDAFKQLVESKtlafdSLPSYQD-DQILLVQSSSIVRYLGK 82
                6999*******998888556.46778999*9999777455567*****8.878999*********86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 944.83
//
Query:       EFC35310.1  [L=102]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.014   15.2   0.6      0.019   14.8   0.6    1.2  1  VEFS-Box  VEFS-Box of polycomb protein
      0.016   15.0   0.1       0.03   14.1   0.0    1.5  2  UBA_4     UBA-like domain


Domain annotation for each model (and alignments):
>> VEFS-Box  VEFS-Box of polycomb protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.6   2.1e-06     0.019      31      70 ..      26      65 ..       8      70 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.1e-06
    VEFS-Box 31 leevdsdeDsedevDdealrlkerqmldeftDvnegekel 70
                l+e +sd   e e ++++ ++k ++++d+f D+n    ++
  EFC35310.1 26 LQEHKSDLEWEREHNEKLSKKKRKKQIDNFLDENPRVMNI 65
                799999***************************9876555 PP

>> UBA_4  UBA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   3.4e-06      0.03      10      35 ..       3      28 ..       1      29 [. 0.88
   2 ?   -3.8   0.0       1.3   1.2e+04      33      39 ..      52      58 ..      52      59 .. 0.63

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 3.4e-06
       UBA_4 10 iTGadeekArqlLeannWdLerAisl 35
                ++++ e++Ar +L  +++d   A++ 
  EFC35310.1  3 LCNVCEDEARYYLSIHDFDFKEALQE 28
                678899*****************985 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 1.3
       UBA_4 33 islyFds 39
                i+ ++d+
  EFC35310.1 52 IDNFLDE 58
                5677775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (102 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1825  (0.10179); expected 358.6 (0.02)
Passed bias filter:                      768  (0.0428356); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.35s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 582.06
//
Query:       EFC35311.1  [L=142]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.067   13.2   0.1       0.09   12.8   0.1    1.2  1  HypA      Hydrogenase/urease nickel incorporation, metallocha


Domain annotation for each model (and alignments):
>> HypA  Hydrogenase/urease nickel incorporation, metallochaperone, hypA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1     5e-06      0.09      45     108 ..      10      81 ..       3      85 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 5e-06
                 HHHHHHHHCC.T.TTT-EEEEEEE--EEEETTTS-EEECHHHHHS-TT.......TSSS-EEEEESSSEEEE CS
        HypA  45 efafellaegtv.legaeLeieevpvkvrCreCgkefeleekalrCpk.......CgsadveivsGeellvk 108
                   af +++e+ +  ++++ +i+  + k  C++C++e +l+++  +Cp+       C s+  +i++ +e++++
  EFC35311.1  10 VEAFFFVHENYIwRNSSNAHINFGEGKSFCHDCNTESDLNHYIHECPAldsaryfCLSKISDILDQRECKLT 81 
                 566777778888566788999999**************9986567986333333355555555556666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (142 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.53
# Mc/sec: 802.72
//
Query:       EFC35312.1  [L=266]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1847  (0.103017); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1766.76
//
Query:       EFC35313.1  [L=165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-50  171.2   0.3    2.1e-50  171.1   0.3    1.0  1  Pro_isomerase  Cyclophilin type peptidyl-prolyl cis-trans iso
     0.0073   16.3   0.0      0.011   15.8   0.0    1.3  1  Thioredoxin_3  Thioredoxin domain


Domain annotation for each model (and alignments):
>> Pro_isomerase  Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  171.1   0.3   2.4e-54   2.1e-50       2     157 ..       8     163 ..       7     164 .. 0.89

  Alignments for each domain:
  == domain 1  score: 171.1 bits;  conditional E-value: 2.4e-54
  Pro_isomerase   2 vdietss..kGrivieLfadkaPktvenFlklvkeg....fYdgttFhRvikgfmvqgGdptgktsageqe.kkggesiraipdEitsklkh.krG 89 
                    +di+++   +Gr+v+eL++d +Pkt+enF++l+ +g     Y+g++FhRvik+fm+qgGd+t+   +g++  +  g    +++dE+  k kh  +G
     EFC35313.1   8 FDITIGAapAGRVVFELYNDIVPKTAENFRALC-TGekgfGYKGSIFHRVIKDFMIQGGDFTNF--NGTGGkSIYG---TKFEDENF-KEKHtIPG 96 
                    6777766779***********************.5668899*******************9988..4453323333...69*****5.5566699* PP

  Pro_isomerase  90 alamartgkepnsagsqFfItlkeaphldgkytvFGkVveGmdvvekiekvetde.erpkknvkivsae 157
                    +l+ma++g  +n++gsqFf+t+ ++p+ldgk++vFGkVveG+++++kie  +t++ + p ++vki++++
     EFC35313.1  97 LLSMANAG--KNTNGSQFFVTTVPCPWLDGKHVVFGKVVEGYEIIKKIEGSKTNQrDTPLSEVKIADCG 163
                    *******8..6******************************************999***********97 PP

>> Thioredoxin_3  Thioredoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   1.2e-06     0.011      42      75 ..     109     142 ..      87     143 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.2e-06
                    HHHCT-SSSSEEECTTCEEEESS---CCHHHHHH CS
  Thioredoxin_3  42 iekygVmsvPalvidgkvvvsGkvpseeeirkll 75 
                     +++ V++vP   +dgk vv Gkv +++ei k +
     EFC35313.1 109 GSQFFVTTVPCPWLDGKHVVFGKVVEGYEIIKKI 142
                    56788************************97765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       350  (0.0195214); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1004.85
//
Query:       EFC35314.1  [L=410]
Description: hypothetical protein NAEGRDRAFT_54982, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.031   14.1   1.4       0.08   12.8   1.4    1.7  1  IQ           IQ calmodulin-binding motif
       0.12   13.0   8.5      0.082   13.5   2.6    2.5  2  AAA_assoc_C  C-terminal AAA-associated domain


Domain annotation for each model (and alignments):
>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   1.4   8.9e-06      0.08       4      19 ..     255     270 ..     255     272 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 8.9e-06
                 HHHHHHHHHHHHHHHH CS
          IQ   4 aikIQaawRGylaRkr 19 
                 a+kIQ+ +R++ a++r
  EFC35314.1 255 AVKIQRNVRRWIAKRR 270
                 89************98 PP

>> AAA_assoc_C  C-terminal AAA-associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.4     0.025   2.3e+02      58      94 ..     251     287 ..     219     312 .. 0.74
   2 ?   13.5   2.6   9.1e-06     0.082      41     109 ..     335     402 ..     322     405 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.025
  AAA_assoc_C  58 qllklvplaaairrvLderenkrlpeerfldeLeekl 94 
                  q+   v++ + +rr++++r++ +++eer ++  e  +
   EFC35314.1 251 QIEMAVKIQRNVRRWIAKRRADKIREEREEEFQETIY 287
                  6777899999999999999999999988554444334 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 9.1e-06
  AAA_assoc_C  41 rkfveadikerKeifreqllklvplaaairrvLderenkrlpeerfldeLeeklseeeaertletaieW 109
                  ++  +a++ erK+ ++e l k  +l ++i+r L+   n++ ++e++++ Le+  +++++e + +t +++
   EFC35314.1 335 NSTTKAGTIERKHAMKELLRKQTKLLQTIDR-LKIVANQQNKQENIQKDLEKMAQPKKVEYSNTTRVNY 402
                  567789999**********************.8***********************9999988887766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3098  (0.172793); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.47
# Mc/sec: 2599.67
//
Query:       EFC35315.1  [L=103]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       947  (0.0528195); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 590.93
//
Query:       EFC35316.1  [L=284]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (284 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 1602.07
//
Query:       EFC35317.1  [L=371]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-14   54.4   1.3    3.2e-14   52.9   1.2    1.7  1  Pkinase         Protein kinase domain
    7.2e-14   51.7   1.9    3.2e-13   49.5   1.9    1.9  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0039   16.0   0.0     0.0066   15.3   0.0    1.3  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.055   13.4   0.0       0.12   12.3   0.0    1.5  2  APH             Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.9   1.2   7.1e-18   3.2e-14      22     195 ..      49     232 ..      41     249 .. 0.76

  Alignments for each domain:
  == domain 1  score: 52.9 bits;  conditional E-value: 7.1e-18
                 TTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH......HHSS--HHHHHHHHHHHHHHHHH CS
     Pkinase  22 etgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle......rkgslseeeakkiakqilegley 113
                 +++++v++ ++++ + +   e +k  +  ki+k ++hpniv++ +v+  +++l++ +     + l++l+       ++++l+ + +  +a+q+ + l +
  EFC35317.1  49 NSKEKVVIRMVENLDPEVLAEfEKEYEAAKIVKDINHPNIVKINKVIPYEKYLIIEMPKYFSD-LEQLVLqnetasEETCLPTDLIFMVAYQLTNTLVF 146
                 6677888888887777776665666667899*****************999999888755544.6665552333345556666688999********** PP

                 HHHTTEE-SS-SGGGEEEETTTE......EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHHHHHHSS- CS
     Pkinase 114 lHskgiiHrDlKpeNiLidekge......lKitDFGlakelessskltsfvgtseYlAPEvl..keneyskkvDvWslGvilyelltgkp 195
                 l  k+iiHrD+  +N+L++e ++      + ++DF    +++s+   +   g+ +  +   +    + ys++ DvW lG i+y+++tg  
  EFC35317.1 147 LETKKIIHRDISLANLLVEEFDKekgilkIVLADFE---RMHSGP-PKMCDGDIDLSSGGQVtsPPELYSETYDVWELGAIIYQMITGDL 232
                 ******************963333588445567884...555555.56666777776666663333568******************976 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.5   1.9   7.2e-17   3.2e-13      19     147 ..      43     181 ..      29     291 .. 0.74

  Alignments for each domain:
  == domain 1  score: 49.5 bits;  conditional E-value: 7.2e-17
                  EEETTTTSSEEEEEEEEESTTSSHHHHHHHHHH...HHHHHTS-BTTB--EEEEEESSSSEEEEEE--TT.EBHHHHHHHT....CTTTSBHHHHHHH CS
  Pkinase_Tyr  19 tlkgekekkevkVavKtlkeeateeekeellee...akimkklkhpnivkllgvctkeepllivteyvkg.GdLlkfLrkk....ekekltlkdllsf 108
                  ++  ++ ++++kV+++++ e+ + e  +e+ +e   aki k+++hpnivk+  v+  e+  ++++e+ k+  dL++ + ++    e++ l ++ ++ +
   EFC35317.1  43 EIL-KDLNSKEKVVIRMV-ENLDPEVLAEFEKEyeaAKIVKDINHPNIVKINKVIPYEK--YLIIEMPKYfSDLEQLVLQNetasEETCLPTDLIFMV 136
                  444.6778999*******.555555577777652227899************9999543..6777777763699998888878777788888889999 PP

                  HHHHHHHHHHHHHTTEEEST-SGGGEEEEE....TTEEEE..-ST CS
  Pkinase_Tyr 109 alqvAkGmeyLeskklvHrdlaarNvLlse....nkvvki..sDf 147
                  a+q+ + + +Le+kk++Hrd++  N L++e    + + ki  +Df
   EFC35317.1 137 AYQLTNTLVFLETKKIIHRDISLANLLVEEfdkeKGILKIvlADF 181
                  *****************************8766655555522555 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   1.5e-06    0.0066     324     357 ..     148     182 ..     138     190 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1.5e-06
  Pkinase_fungal 324 lkagiLHrDiSenNilitds.kkegerkglLiDLD 357
                     ++++i+HrDiS  N+l+ +  k++g  k +L+D++
      EFC35317.1 148 ETKKIIHRDISLANLLVEEFdKEKGILKIVLADFE 182
                     5899**************98455577788888876 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       1.7   7.8e+03     212     229 ..      58      75 ..      54      78 .. 0.74
   2 ?   12.3   0.0   2.6e-05      0.12     151     201 ..     124     189 ..     100     193 .. 0.65

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.7
                 CSCHCCCHCHHHHHHHHC CS
         APH 212 wtseldpeflaallraye 229
                  +++ldpe+la++ ++ye
  EFC35317.1  58 MVENLDPEVLAEFEKEYE 75 
                 477889999999999987 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.6e-05
                 H...........HHHHHHHH--SSS-EEEE-SS-SGGGEEEC.....TTEEEEE-.--TT-EEEEC CS
         APH 151 q...........vlaalaallpgelptvllHgDlhpgNllvd...pddgrvtGvi.Dfedaglgpp 201
                 +           v+ +l  +l   + + ++H+D+++ Nllv+   +++g ++ v+ Dfe+++ gpp
  EFC35317.1 124 EetclptdlifmVAYQLTNTLVFLETKKIIHRDISLANLLVEefdKEKGILKIVLaDFERMHSGPP 189
                 1344444444445555555555589999**************886555555434369999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       757  (0.0422221); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.56
# Mc/sec: 1983.19
//
Query:       EFC35318.1  [L=215]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      1e-05   25.2   0.0    2.6e-05   23.9   0.0    1.5  2  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    0.00014   21.4   0.2    0.00025   20.6   0.2    1.5  1  adh_short     short chain dehydrogenase


Domain annotation for each model (and alignments):
>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.23   2.1e+03      86     118 ..      59      91 ..      53      97 .. 0.75
   2 !   23.9   0.0   2.9e-09   2.6e-05     122     178 ..     115     175 ..     105     197 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.23
                   -GGGH-HHHHHHHHHHHTHHHHHHHHHHHHHCT CS
  adh_short_C2  86 pfletsreefdraldvnlyslfllakaalplmk 118
                   ++ ++s  e+ + + +n+ s + la ++ ++mk
    EFC35318.1  59 KLSDVSVTEIVESQMINTVSPTILASELFEIMK 91 
                   566777777777888888888888888888776 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 2.9e-09
                   EEEEEEEGGGTSBSTTTT....HHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTG CS
  adh_short_C2 122 sivnlssvgaervvpnyn....aygaaKaalealtrylAvelgpkgiRvNavspgpikTla 178
                    i+n++s  ++  +++ +      +++Ka+l+ ltr++   ++++gi vN+v  g++   +
    EFC35318.1 115 FIINVTSHEGQFETSGKSdshiQTNTSKASLNMLTRSCSEYYARNGILVNSVDTGWVSSAL 175
                   58999999887665554444567899*******************************9766 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.2   2.8e-08   0.00025     131     186 ..     116     175 ..      55     181 .. 0.86

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 2.8e-08
                 EEEEEEGGGTSB-TTBH....HHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHH CS
   adh_short 131 IvnvsSvagkvpvagva....aYsAsKaavagltrslakelaptgirvnavaPGlvdTdm 186
                 I+nv+S  g+ +  g +       +sKa +++ltrs ++ +a+ gi vn+v +G v++++
  EFC35318.1 116 IINVTSHEGQFETSGKSdshiQTNTSKASLNMLTRSCSEYYARNGILVNSVDTGWVSSAL 175
                 999999999776655432111678*******************************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       354  (0.0197445); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1390.83
//
Query:       EFC35319.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.6e-56  189.9   0.0    6.2e-56  189.7   0.0    1.0  1  Actin        Actin
  ------ inclusion threshold ------
      0.023   13.5   0.0      0.028   13.2   0.0    1.1  1  MreB_Mbl     MreB/Mbl protein
       0.11   12.0   0.0       0.14   11.6   0.0    1.1  1  BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  189.7   0.0     1e-59   6.2e-56     236     405 ..       1     158 []       1     158 [] 0.98

  Alignments for each domain:
  == domain 1  score: 189.7 bits;  conditional E-value: 1e-59
       Actin 236 iKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleeekskllgiselivaainacdvdlrpeLlanivvtGGn 334
                 +Ke++c+v  ++e +e+k+ s  e++YeLPDg+ i++g+e+f+++E+ F+p+lig+e           gi+e i ++i +cdvd+r+e+++niv++GG+
  EFC35319.1   1 MKEKLCYVTTNFE-EESKKGSLLETEYELPDGNIITIGSEKFRTTEVFFHPNLIGMEVG---------GIHEHIATSIRKCDVDIRKEMYSNIVLSGGS 89 
                 7***********9.999999************************************988.........******************************* PP

       Actin 335 sllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGssvverk 405
                 +l++g+ eRl++el++ +s+++k +iia + +rky aW+GGSi+Asl+t +++++ k+EY+E G+++v+rk
  EFC35319.1  90 TLFNGIAERLSNELQE-ISPSMKNRIIALP-DRKYQAWVGGSIFASLSTYNKMCIRKEEYDETGPNIVHRK 158
                 ****************.9999*********.**************************************98 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   4.7e-06     0.028     247     298 ..      54     104 ..      38     114 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.7e-06
                 HHHHHHHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHS CS
    MreB_Mbl 247 kepvsaiveavkevLektppeLaadivdrgivltGGgallkgldkllseetg 298
                   +v  i e +++ ++k+  ++ ++++ + ivl+GG++l++g+ + ls+e++
  EFC35319.1  54 GMEVGGIHEHIATSIRKCDVDIRKEMYSN-IVLSGGSTLFNGIAERLSNELQ 104
                 56788999*****************9876.99****************9986 PP

>> BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   2.3e-05      0.14     197     267 .]      59     132 ..      57     132 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.3e-05
                  HHHHHHHHHHHHHHHTT---SS..EEEESGGGG-HHHHHHH.....HHHH-S..-EE--GGGGGHHHHHHHHHH CS
  BcrAD_BadFG 197 glhraialrvialisrsggvtde.vtltGGvakneaavkelrklvkenygev..kininpdsiytgalGAalfA 267
                  g+h+ ia+++ +    +  +    ++l GG    +++ + l + ++e    +   i   pd +y++ +G ++fA
   EFC35319.1  59 GIHEHIATSIRKCDVDIRKEMYSnIVLSGGSTLFNGIAERLSNELQEISPSMknRIIALPDRKYQAWVGGSIFA 132
                  678888877777655544443336*********99********999977666448999*************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       423  (0.0235931); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 989.28
//
Query:       EFC35320.1  [L=165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-11   44.2   0.0    2.3e-11   43.9   0.0    1.1  1  NAD_binding_10  NAD(P)H-binding


Domain annotation for each model (and alignments):
>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.9   0.0   1.3e-15   2.3e-11      92     183 ..       2     101 ..       1     102 [. 0.77

  Alignments for each domain:
  == domain 1  score: 43.9 bits;  conditional E-value: 1.3e-15
                     EEEEEEETTTTSGCGCHHHH.HHHH.CCHHHHHHHHHHHHHH....HHSSSEEEEEEE-CEE-ST.--SEEEEETTS.S----EEEHHHHHHHHH CS
  NAD_binding_10  92 Rfvlvsaigvgdevpgefge.wnke.llkaylaakraaeell....rasgldwTivrpggLtdep.ttkyrvvekge.pfkggsisradVAdvlv 178
                     R+ +++++g+ d  ++ f + + k+ ++ +++++ + +e+ l    ++s++++ ivrp+ L d p t +++ +e+++ p ++++++r+dVA +l+
      EFC35320.1   2 RIAIITSAGILDVKQSWFFDnILKKyIIHNVYQDLANSERTLcqltKDSKITYAIVRPPQLVDSPiTLDFEYGEDNNyPKGSSKVTRQDVASFLL 96 
                     899********9666554431333236677788888888876333366*****************8889**9988773566679*********** PP

                     HHCTX CS
  NAD_binding_10 179 avldd 183
                     ++l d
      EFC35320.1  97 RSLFD 101
                     99976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 1062.44
//
Query:       EFC35321.1  [L=170]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    9.7e-23   80.3   1.7    1.2e-22   80.0   1.7    1.1  1  HSP20       Hsp20/alpha crystallin family
    2.7e-05   23.6   0.0    3.9e-05   23.1   0.0    1.3  1  ArsA_HSP20  HSP20-like domain found in ArsA


Domain annotation for each model (and alignments):
>> HSP20  Hsp20/alpha crystallin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.0   1.7   1.3e-26   1.2e-22       1     101 [.      57     165 ..      57     166 .. 0.90

  Alignments for each domain:
  == domain 1  score: 80.0 bits;  conditional E-value: 1.3e-26
                 E--SSEEEEEEEEE-TT--CCCEEEEEETTE..EEEEEE--....---TT----SS---EEEEEE--STTB-TTT-EEEEETTEEEEEEEBSS--.... CS
       HSP20   1 dikeeeeefevkldvpglkkeelkvkvednr..vlvkgehe..eeeedekglikerssrkFsrkftLPenvdadkvkaslkdGvLtvtvpkkepekk.. 93 
                 d+ke+++efe+ +d+pg++k+e++  +++++  ++ kge++  +ee++++++iker +++F+r+f +P nv+ d++ka+lk+G L++t+pk e++++  
  EFC35321.1  57 DVKESDKEFELLADIPGFSKNEINCLIDQDKhlLTLKGEKKeeNEENEGNYIIKERYYNSFTRHFDIPSNVNLDQIKAQLKNGQLKLTIPKLENQNEte 155
                 689*********************8888777779*****99889999999*******************************************998765 PP

                 ..-------- CS
       HSP20  94 ..kkerkiqi 101
                   ++ ++i+i
  EFC35321.1 156 nvNNIKNIEI 165
                 5566666666 PP

>> ArsA_HSP20  HSP20-like domain found in ArsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.0   4.4e-09   3.9e-05       1      62 [.      62     144 ..      62     145 .. 0.91

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 4.4e-09
  ArsA_HSP20   1 ddeyvlkldLPfvdkeeidlsrs..gdeLtIkig....................nfrRqitLPsvlarkevtsAkfedgvLeIr 62 
                 d+e++l +d+P+++k ei+  ++     Lt+k +                    +f R++  Ps ++ +++ +A++++g L+ +
  EFC35321.1  62 DKEFELLADIPGFSKNEINCLIDqdKHLLTLKGEkkeeneenegnyiikeryynSFTRHFDIPSNVNLDQI-KAQLKNGQLKLT 144
                 6899*************99665522778999999*************************************.*********975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       655  (0.036533); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 987.18
//
Query:       EFC35322.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-51  169.7   5.9    4.1e-15   55.2   0.2    5.7  5  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.7   3.9e-09     7e-05       2      39 ..     124     162 ..     123     165 .. 0.95
   2 !   36.7   0.0   1.4e-13   2.5e-09       1      49 []     170     216 ..     170     216 .. 0.95
   3 !   44.4   0.0   5.5e-16   9.9e-12       1      41 [.     218     258 ..     218     262 .. 0.96
   4 !   24.0   0.1   1.3e-09   2.3e-05       1      45 [.     243     286 ..     243     290 .. 0.90
   5 !   55.2   0.2   2.3e-19   4.1e-15       1      45 [.     292     336 ..     292     338 .] 0.98

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 3.9e-09
     DUF4116   2 rEivleavkkngsalky.lseeLknDkeivlkAvkqngt 39 
                 +E+v ++++k  + l y ++++Lk+D+++ l+  k++g+
  EFC35322.1 124 KEFVIKLIEKSEYDLSYeIPKKLKKDRDVNLASAKKHGI 162
                 8****************99**************999996 PP

  == domain 2  score: 36.7 bits;  conditional E-value: 1.4e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+ a ++ g+ l  l++e++nD+eiv++Av +ng +l+ + +eL+
  EFC35322.1 170 DREIVMAAASS-GN-LSWLPKEFSNDREIVMAAVANNGRILRGVGDELK 216
                 9**********.55.***************************9999997 PP

  == domain 3  score: 44.4 bits;  conditional E-value: 5.5e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 DrEiv +a++++g+a+  ++ee+++D+e++  Avkqng a+
  EFC35322.1 218 DREIVRKAIENDGCAIADAPEEFQKDRELAEMAVKQNGRAF 258
                 9*************************************987 PP

  == domain 4  score: 24.0 bits;  conditional E-value: 1.3e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 DrE++  avk+ng a+  l  e+ nD+e+++ A+k + t+++ ++
  EFC35322.1 243 DRELAEMAVKQNGRAFICLK-EFENDRELLKIAIKGDTTIIDKLP 286
                 9******************9.**************8887776655 PP

  == domain 5  score: 55.2 bits;  conditional E-value: 2.3e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 DrEi++ av+k+g+a+ky+s +L+n k+iv+kA+++n+++l+y +
  EFC35322.1 292 DREIIMLAVEKDGLAIKYASADLRNQKDIVMKAIEKNPDVLCYTP 336
                 9******************************************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1448  (0.080763); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 2341.56
//
Query:       EFC35323.1  [L=358]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        7.2    7.2  13.9        1.7    9.2   0.6    4.6  5  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   2.5     0.021   3.8e+02       2      30 ..      66      97 ..      65     101 .. 0.79
   2 ?   -1.5   0.0      0.22   3.9e+03      20      30 ..     155     165 ..     145     188 .. 0.59
   3 ?    0.0   0.0     0.072   1.3e+03      22      30 ..     213     221 ..     204     247 .. 0.70
   4 ?    9.2   0.6   9.4e-05       1.7       4      32 ..     272     298 ..     270     314 .. 0.76
   5 ?   -2.3   0.0      0.37   6.7e+03       8      30 ..     339     349 ..     331     356 .. 0.47

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.021
                S--EEE--SS---E-S-HH...H-TT--EEE- CS
       LRR_4  2 nLevLdLsnNqltdiplle...klpnLkeLdL 30
                nL++L L +  lt+  l++   k  +L++L L
  EFC35323.1 66 NLKELELDDIPLTKNKLFKiltKTRKLETLVL 97
                89999999999999999554447888999988 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.22
                 HH-TT--EEE- CS
       LRR_4  20 eklpnLkeLdL 30 
                 ek  n +e+d+
  EFC35323.1 155 EKQSNIEEIDV 165
                 55566666664 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.072
                 -TT--EEE- CS
       LRR_4  22 lpnLkeLdL 30 
                 +pnL+ +d+
  EFC35323.1 213 NPNLEFVDI 221
                 677777776 PP

  == domain 4  score: 9.2 bits;  conditional E-value: 9.4e-05
                 -EEE--SS---E-S-HHH-TT--EEE.-.- CS
       LRR_4   4 evLdLsnNqltdiplleklpnLkeLd.Lsg 32 
                 e +d ++N++ ++p+   ++nLk++  +s+
  EFC35323.1 272 EAIDVNSNNIATLPS---CKNLKTVFwMSE 298
                 568999******999...*****9643544 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 0.37
                 --SS---E-S-HHH-TT--EEE- CS
       LRR_4   8 LsnNqltdiplleklpnLkeLdL 30 
                  s+           +++ ++L +
  EFC35323.1 339 ASG-----------CDSIEYL-I 349
                 332...........4444444.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       410  (0.022868); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.39u 0.23s 00:00:00.62 Elapsed: 00:00:00.36
# Mc/sec: 2953.17
//
Query:       EFC35324.1  [L=328]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-22   80.6   0.3    5.4e-22   78.8   0.0    1.8  2  Peptidase_S10  Serine carboxypeptidase


Domain annotation for each model (and alignments):
>> Peptidase_S10  Serine carboxypeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.8   0.0     3e-26   5.4e-22     267     396 ..      33     163 ..       5     167 .. 0.90
   2 ?   -0.9   0.6     0.045   8.1e+02     197     231 ..     215     253 ..     176     305 .. 0.46

  Alignments for each domain:
  == domain 1  score: 78.8 bits;  conditional E-value: 3e-26
                    CCCTTTTTCHHHHHHHHTSHHHHHHTT--..TTSSS--SB-HHHHHHCTCCC-SBCHHHHHHHHHTT-EEEEEEETT-STT-HHHHHHHHHHTECT CS
  Peptidase_S10 267 aqggedpydesyvekylnkkeVrkalhvn..asvkkweecndsvfeqleddisksveeileellesglrvliynGdvDlicnvlgteawikklels 360
                    +++++ ++ +++v +y+n++ Vr+a++++   + + w+ c++ +   ++++i++++ +++++ll + +r+l+y+GdvD++ n+lgt+a i+kl+l+
     EFC35324.1  33 DESDSPCVPDHSVISYFNTPAVRSAIGAThiGNPNGWQVCSTFI---NYTTIYTTMLPFYTKLLPQ-IRILVYSGDVDTVLNTLGTQAGINKLGLT 124
                    55678899999*****************99988899******99...689999*************.***************************** PP

                    TECCSCCCEEEETTTCESEEEEEEEETT...EEEEEETT CS
  Peptidase_S10 361 gkkefrpwevspkkengqvaGyvkeyen...ltfltvkg 396
                    ++ ++++w ++  + n +v G++k+y+n   ltf+tv+g
     EFC35324.1 125 VSVPYSQWLHNDVNGNPVVDGFYKKYSNgrgLTFVTVRG 163
                    **********99**************55567******98 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.045
                    TTSSHHHHHHHHHHHHEET....HHHHHHHHHHHHHHHH CS
  Peptidase_S10 197 hgliseeeyeslkkacekk....eeleqesekcanllek 231
                     +  +e++ e +++++++k    +++++e+++c+++  +
     EFC35324.1 215 TSSSDESDKEGVENENHHKrkltRRIRKEEKTCKKKKIN 253
                    222222223333333322222222333333333222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1702  (0.09493); expected 358.6 (0.02)
Passed bias filter:                      695  (0.038764); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.46
# Mc/sec: 2147.97
//
Query:       EFC35325.1  [L=476]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0013   18.7   0.0     0.0036   17.2   0.0    1.7  1  DUF4488   Domain of unknown function (DUF4488)
  ------ inclusion threshold ------
      0.053   11.8  20.5      0.088   11.1  20.5    1.3  1  CDC45     CDC45-like protein
        0.6    8.2  28.3          1    7.5  28.3    1.3  1  Nop14     Nop14-like family
        9.9    5.4  38.0      0.039   13.3  25.6    2.0  2  Nop53     Nop53 (60S ribosomal biogenesis)


Domain annotation for each model (and alignments):
>> DUF4488  Domain of unknown function (DUF4488)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   8.1e-07    0.0036      33      80 ..     118     167 ..     112     177 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 8.1e-07
     DUF4488  33 ddgkfvnlvleeksgasiiigyGeYelksdsvyvEsveks..vhlpqleg 80 
                 + g+++nlv++ek++a   + +G+++ k+++ + E+v+k+  v+ +ql++
  EFC35325.1 118 EGGNMMNLVMFEKAHAHNTVITGKFTKKAEQLIEEHVKKNprVKASQLKK 167
                 6799***********************************94456666655 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1  20.5     2e-05     0.088      99     203 ..     338     437 ..     258     471 .. 0.41

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 2e-05
       CDC45  99 eekerivvfDDgdieeeleeereayealeeeeesdeede....eeeeeddddeeeeeeeeedeedeeedeeeskkkrk....sksdeeeesddddersr 189
                  + e++ + +D+d     +e+++a+ + e ++e+d+e +    e ++++++d+eeee ee+ +  eee+ee++kkk+k    ++      ++ ++++++
  EFC35325.1 338 VGGESVEINNDEDY----CENNNAVDEDEVDDEVDDEVDevdeEVDNNSENDDEEEEGEEDGDYVEEEEEERRKKKTKvtkkKW------KNVTRRKQE 426
                 44455555555553....444444444444444442222221111111111111222221122222222222222222211111......111111111 PP

       CDC45 190 krrrsepsakklrr 203
                 k++++e   +   +
  EFC35325.1 427 KKNEEE---EGESK 437
                 111111...11111 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5  28.3   0.00023         1     337     435 ..     346     435 ..     310     467 .. 0.41

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00023
       Nop14 337 gkglka.taeeeeeededdfeedddlveseseeeeeeeeedeeeeedeeeee.eeeededdlsdlese..........eeeeedeleeelleeekkaae 423
                 +++ ++ ++++  +ede d+e dd+ +e ++e+++++e++deeee +e+ +  eeee+e  +++++            +             +ekk++e
  EFC35325.1 346 NNDEDYcENNNAVDEDEVDDEVDDEVDEVDEEVDNNSENDDEEEEGEEDGDYvEEEEEERRKKKTKVTkkkwknvtrrK-------------QEKKNEE 431
                 1111112222224444444444443344444444433333333333333333222222222222222222222222221.............1111111 PP

       Nop14 424 ekkekkkkkkks 435
                 e        + +
  EFC35325.1 432 E--------EGE 435
                 1........111 PP

>> Nop53  Nop53 (60S ribosomal biogenesis)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   4.5      0.42   1.9e+03      38      96 ..     144     205 ..     129     237 .. 0.53
   2 ?   13.3  25.6   8.7e-06     0.039     233     338 ..     359     465 ..     337     476 .] 0.54

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.42
       Nop53  38 kkdeeLFvvDtkgdeel.kkkarkkkkkpL..ksdeiLaqrsavpavsakrkrkkakkkkkk 96 
                 kk e+L  + +k++ ++ +++++k+++ +L  k  + L ++ av ++ +k+k k+  +++ k
  EFC35325.1 144 KKAEQLIEEHVKKNPRVkASQLKKRRSTNLvaKDCSALLNNDAVASLVRKKKDKHYGQNRFK 205
                 44456666666666666555555555555522555677788888777766655554222222 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 8.7e-06
       Nop53 233 eareeelseekdegleeeeeeeeeeeeeeeeeeeesee....eeklnapvkkkpkrKTkaqRnk...ekrrkeeekeekeekkekkkeaqlerlkeikk 324
                 ++ e  ++e +de   +e +ee ++++e+++eeee ee        +++++++ k+KTk  ++k     rrk+e+k e+ee + k ++ ++++ +  ++
  EFC35325.1 359 DEDEV-DDEVDDE--VDEVDEEVDNNSENDDEEEEGEEdgdyV---EEEEEERRKKKTKVTKKKwknVTRRKQEKKNEEEEGESKNEKTKISHFRRWNE 451
                 22222.1222221..1222222222222222222222222232...22233334666666665511166899999999999999999999****99999 PP

       Nop53 325 evaekekeraeaae 338
                 +v+   ++r+++  
  EFC35325.1 452 DVKSLGSKRKRNVV 465
                 99999999888744 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (476 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2716  (0.151486); expected 358.6 (0.02)
Passed bias filter:                      614  (0.0342462); expected 358.6 (0.02)
Passed Vit filter:                       126  (0.00702772); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.89u 0.36s 00:00:01.25 Elapsed: 00:00:00.57
# Mc/sec: 2514.24
//
Query:       EFC35326.1  [L=293]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0079   16.1   0.1      0.032   14.2   0.1    2.0  1  DUF3924   Protein of unknown function (DUF3924)
  ------ inclusion threshold ------
      0.015   16.0   3.8       0.16   12.7   0.7    3.0  4  DUF3349   Protein of unknown function (DUF3349)


Domain annotation for each model (and alignments):
>> DUF3924  Protein of unknown function (DUF3924)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.1   3.6e-06     0.032      17      51 ..     101     135 ..      97     141 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 3.6e-06
     DUF3924  17 dllkqayekktGasisestlvqtliskefiqaitP 51 
                 dllk  +    G s s  t+vq +isk f  +  P
  EFC35326.1 101 DLLKEEFKVTLGLSSSKETMVQEIISKLFSSSPSP 135
                 9**************************99776665 PP

>> DUF3349  Protein of unknown function (DUF3349)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.68   6.1e+03      52      64 ..      16      28 ..       3      67 .. 0.65
   2 ?   -3.5   0.0         2   1.8e+04      71      72 ..      62      63 ..      39      80 .. 0.51
   3 ?    2.8   0.0     0.023   2.1e+02      43      78 ..      99     137 ..      92     154 .. 0.70
   4 ?   12.7   0.7   1.8e-05      0.16      33      72 ..     254     292 ..     251     293 .] 0.94

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.68
                .SSS.BSHHHCHH CS
     DUF3349 52 eadeavdeediee 64
                +a+++v+++die+
  EFC35326.1 16 TAPKTVSSTDIEK 28
                3444444444444 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2
                TS CS
     DUF3349 71 ee 72
                ++
  EFC35326.1 62 QK 63
                22 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.023
                 HHHHHHH-.-...SSS.BSHHHCHHHHHHHCTS---HHH CS
     DUF3349  43 aeelvaea.a..eadeavdeedieelitkvteeepseed 78 
                  ++l++e+ +     ++ +e+ ++e+i+k+ ++ ps++d
  EFC35326.1  99 LRDLLKEEfKvtLGLSSSKETMVQEIISKLFSSSPSPKD 137
                 555555553122445566788899999999999999988 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 1.8e-05
                 T--HHHHHHHHHHHHHH--.SSS.BSHHHCHHHHHHHCTS CS
     DUF3349  33 rLsdeevkevaeelvaeaaeadeavdeedieelitkvtee 72 
                 +L+ +e+ +v++++ +++ +a+++++++ i+ +itk+t++
  EFC35326.1 254 KLTSDEIVSVITDIRSQR-DAKKQISDKTIHGAITKITNK 292
                 79**************99.89****************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1305  (0.0727871); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1772.96
//
Query:       EFC35327.1  [L=113]
Description: WD40 repeat domain-containing protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0016   19.3   0.1     0.0047   17.8   0.0    2.0  2  WD40         WD domain, G-beta repeat
  ------ inclusion threshold ------
       0.04   14.2   0.0      0.063   13.6   0.0    1.4  1  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   5.2e-07    0.0047       7      38 .]      56      88 ..      35      88 .. 0.87
   2 ?   -2.4   0.0       1.2   1.1e+04      31      36 ..      93      98 ..      92      98 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 5.2e-07
                EESSSS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  7 ltGHss.vtslafspdgawlasGsdDgtvriWd 38
                +t H++ v+  +f p g ++asG++ g+vriW+
  EFC35327.1 56 YTQHTHkVNVAKFAPTGFYIASGDESGNVRIWS 88
                677855697778********************5 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.2
                TSEEEE CS
        WD40 31 Dgtvri 36
                D+t+++
  EFC35327.1 93 DKTIKL 98
                9***97 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0     7e-06     0.063      35      89 ..      57     112 ..      40     113 .] 0.79

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 7e-06
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksek.avtclgW 89 
                  +++ ++v+  ++ p g  +a + + g+vr+ + e+++   +l+    + +v  l W
   EFC35327.1  57 TQHTHKVNVAKFAPTGFYIASGDESGNVRIWSTENADKTIKLEKRVLSkSVRDLAW 112
                  4678899999************************9977666654332225777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (113 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       333  (0.0185733); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.33s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 675.14
//
Query:       EFC35328.1  [L=177]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-07   29.8   0.0      3e-07   29.6   0.0    1.0  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6   0.0   1.7e-11     3e-07      21     135 ..      32     141 ..      15     156 .. 0.81

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 1.7e-11
                 CHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGH.HHHHHHHHHHHHHHTSHSTT.THHHH CS
        p450  21 elhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfang.ekwkklRrfltptltsfgkl.sleel 117
                  l ++++k+     ++frl   + ++v +s+p++ ke +i+k+++f++  ++++ a     f g+++l a+  e wkk+ ++++p++  + +l  l ++
  EFC35328.1  32 DLVKAVEKYGDPITKTFRLTTSKSNSVWISDPKLLKEYFIAKAHNFEKP-NYNVAA-----FFGENILSAQNnESWKKHFKVCNPAFGPK-NLkYLCKV 123
                 4445555555556789**************************9888883.544444.....666666666666***************99.88899*** PP

                 HHHHHHHHHHHHHCCCCH CS
        p450 118 veeeaedlveklrkkage 135
                   e+ + + e+++++++ 
  EFC35328.1 124 AVESCNSMFEMWDRRCDG 141
                 ************999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       395  (0.0220313); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.27s 00:00:00.67 Elapsed: 00:00:00.43
# Mc/sec: 1239.70
//
Query:       EFC35329.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1307  (0.0728987); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 1615.71
//
Query:       EFC35330.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-07   29.4   5.8    7.2e-07   28.9   5.8    1.2  1  zf-CCCH_4    CCCH-type zinc finger
     0.0007   19.6  10.8     0.0011   18.9  10.8    1.3  1  zf_CCCH_4    Zinc finger domain
     0.0054   16.6   3.9     0.0087   16.0   3.9    1.3  1  zf-CCCH      Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  ------ inclusion threshold ------
      0.052   11.8  26.1      0.066   11.5  26.1    1.2  1  CDC45        CDC45-like protein
      0.068   11.7  21.0       0.11   11.0  21.0    1.3  1  Utp14        Utp14 protein
      0.084   13.2   1.3      0.084   13.2   1.3    2.0  2  zf-UBP       Zn-finger in ubiquitin-hydrolases and other prot
        0.1   12.0  35.8       0.13   11.6  35.8    1.0  1  SDA1         SDA1
       0.14   12.9  12.4       0.11   13.2   3.3    2.6  2  Torus        Torus domain
       0.15   10.3  30.7       0.17   10.0  30.7    1.1  1  Nop14        Nop14-like family
        3.6    6.8  31.7        4.9    6.4  31.7    1.2  1  BUD22        BUD22
        5.5    5.6  11.1        6.9    5.3  11.1    1.3  1  COPI_C       Coatomer (COPI) alpha subunit C-terminus


Domain annotation for each model (and alignments):
>> zf-CCCH_4  CCCH-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   5.8   4.4e-10   7.2e-07       1      21 [.       2      22 ..       2      22 .. 0.95

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 4.4e-10
   zf-CCCH_4  1 rlCpyfakGsCrfGdnCrFsH 21
                ++C+y+++G+Cr+G+ C + H
  EFC35330.1  2 VVCRYWLQGCCRYGNSCWYDH 22
                59***************9988 PP

>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9  10.8   6.7e-07    0.0011       1      19 []       4      22 ..       4      22 .. 0.99

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 6.7e-07
   zf_CCCH_4  1 CkfflqGtCkkGdkCrFaH 19
                C+++lqG C++G++C++ H
  EFC35330.1  4 CRYWLQGCCRYGNSCWYDH 22
                *****************99 PP

>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   3.9   5.3e-06    0.0087       4      25 ..       2      22 ..       1      23 [. 0.93

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5.3e-06
                HCBCHHHHHS--TTGGG-SSBS CS
     zf-CCCH  4 elCrffmrtGyCkyGdrCkFaH 25
                + Cr++++ G C+yG++C + H
  EFC35330.1  2 VVCRYWLQ-GCCRYGNSCWYDH 22
                68******.*********9988 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  26.1   4.1e-05     0.066     107     202 ..      73     173 ..      27     188 .. 0.48

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 4.1e-05
       CDC45 107 fDDgd...ieeeleeereayealeeeeesdeedeeeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdeeee....sddddersrkrrrsepsa 198
                 +DD d   i + l + +e y   +++++  e+++  +e++++d+++e+++ e++ + ++d+ee+++++ +++dee++     ++ ++r+rk+r+ ++s+
  EFC35330.1  73 WDDDDaqkIRNALLHGKELYTYEDDDSDYYEDED--DEDEEEDSDDEDDDLEKKGRINSDDEEDEEDSDEDEDEEKDlnyyANKVSQRHRKKRKLNDSK 169
                 6666622233333334443333333333322221..111111111111111111111111111111111222222224455555667777777777444 PP

       CDC45 199 kklr 202
                 ++++
  EFC35330.1 170 RSTQ 173
                 4433 PP

>> Utp14  Utp14 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0  21.0     7e-05      0.11     297     401 ..      70     169 ..      65     184 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 7e-05
       Utp14 297 rakwdeeaReaiaeqlrrgeeLrrkiegkeededddddsdedssdseeeednseedaeeekrkkleklkeeeeke.eeeeeeepekgllamkFmkraea 394
                  + wd++  ++i++ l  g+eL     +  +d  +d+d++++++ds++e      d+++ek+ +++  +ee+e++ +e+e+ee++ + +a k  +r+++
  EFC35330.1  70 YEDWDDDDAQKIRNALLHGKELYTYEDDD-SDYYEDEDDEDEEEDSDDE------DDDLEKKGRINSDDEEDEEDsDEDEDEEKDLNYYANKVSQRHRK 161
                 57899999999999999999998765333.3333333333333333333......333344444444444333332477788888888999*****999 PP

       Utp14 395 rkk.eend 401
                 ++k ++ +
  EFC35330.1 162 KRKlNDSK 169
                 99943333 PP

>> zf-UBP  Zn-finger in ubiquitin-hydrolases and other protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   1.3   5.1e-05     0.084      20      49 ..       9      38 ..       3      51 .. 0.78
   2 ?   -2.4   0.1       3.8   6.2e+03      49      59 ..      90     100 ..      84     105 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 5.1e-05
                EEE-TTTT-HHHHHHHHH---EEEETTT-- CS
      zf-UBP 20 vgCgrksnghalkHyeetrHplavdlstls 49
                +gC+r+ n++ ++H+++t+H    +++  +
  EFC35330.1  9 QGCCRYGNSCWYDHFKTTEHSPSHQVNLEQ 38
                79*****************97665544443 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3.8
                 -EEETTTTEEB CS
      zf-UBP  49 svycyscddev 59 
                 ++y y++dd  
  EFC35330.1  90 ELYTYEDDDSD 100
                 68999998864 PP

>> SDA1  SDA1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6  35.8   8.1e-05      0.13      72     206 ..      35     176 ..      25     184 .. 0.45

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.1e-05
        SDA1  72 GleLlekwkeeekkekre......eeeedsddeddeedwevesddds....eedseggwidvesdeeeieesdesedeeeeeeeeeekeekeeeeeeee 160
                 +le +++w++e k+++++      + +e   ++++ edw+ +++  +    +    ++  + e+d+ +       ede++e+eee++++e+++ e++ +
  EFC35330.1  35 NLEQIKSWEKELKEQESSlesillDADEHYYENSEYEDWDDDDA--QkirnALLHGKELYTYEDDDSDY-----YEDEDDEDEEEDSDDEDDDLEKKGR 126
                 57778888888888887788898744444344444444444443..22343233333344444444322.....2333322333333333333333322 PP

        SDA1 161 ..eeeeeeeeeeeeeekekkkk..kakeaseeekkkekeeekiskasela 206
                   +++ee+ee+++e+e+e+k+    a++ s++++kk k ++++++++++ 
  EFC35330.1 127 inSDDEEDEEDSDEDEDEEKDLnyYANKVSQRHRKKRKLNDSKRSTQSIN 176
                 22222333333333223333335534444444444444444444444444 PP

>> Torus  Torus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   3.3   6.8e-05      0.11      71      92 ..       2      23 ..       1      36 [. 0.84
   2 ?    4.8   1.5     0.028        45       5      53 ..     124     175 ..     120     185 .. 0.59

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 6.8e-05
                -B-HHHHHT--SSGGG-SSB-S CS
       Torus 71 yfClfFarGlCakGkkCeylHr 92
                ++C ++ +G+C +G++C y H 
  EFC35330.1  2 VVCRYWLQGCCRYGNSCWYDHF 23
                68*****************995 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.028
                 ----S-SS----..----SSS-----TTSS----S-.THHHHS-----S--- CS
       Torus   5 parkqvdeeelk..sekeeqegeeyNiWynkwsgee.kekkkkskekaktrc 53 
                 + r   d+ee +  s+++e+e+++ N + nk s+++ k++k ++++++++ +
  EFC35330.1 124 KGRINSDDEEDEedSDEDEDEEKDLNYYANKVSQRHrKKRKLNDSKRSTQSI 175
                 5566665554442256666666899999999996651333344444444444 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0  30.7   0.00011      0.17     334     446 ..      51     181 ..      22     191 .. 0.40

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00011
       Nop14 334 fglgkgl.ka.....taeee.eeededdfeedd............dlveseseeeeeeeeedeeeeedeeeeeeeeededdlsdleseeeeeedeleee 413
                   l++ l +a     +++e  + +d+d +   +            + ++++s+  e+e++edeee++d+e+++ e++   +++d+e+ee+++ede ee+
  EFC35330.1  51 SSLESILlDAdehyyENSEYeDWDDDDAQ---KirnallhgkelyTYEDDDSDYYEDEDDEDEEEDSDDEDDDLEKKGRINSDDEEDEEDSDEDEDEEK 146
                 22222222111122211111122222222...1223455554433222222222224555555555555555544455555555555555555553333 PP

       Nop14 414 l....leeekkaaeekkekkkkkkkseekakeelpyt 446
                         +k +++++k++k +++k + ++ ++  +t
  EFC35330.1 147 DlnyyA--NKVSQRHRKKRKLNDSKRSTQSINTNSFT 181
                 344321..22222222222333333333334444455 PP

>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4  31.7     0.003       4.9     168     284 ..      42     174 ..      21     183 .. 0.35

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.003
       BUD22 168 esdkeeesedsed..eekeeseddeeeeeededdedaee...............deedeeaeerelaqydgllasddeded.......eyneetdeess 242
                 ++++ +e+e+s +    +++++  e++e ed dd+da++               d++++ +e+++ ++ ++  +sdded+d       +   ++dee++
  EFC35330.1  42 WEKELKEQESSLEsiLLDADEHYYENSEYEDWDDDDAQKirnallhgkelytyeDDDSDYYEDEDDEDEEE--DSDDEDDDlekkgriN---SDDEEDE 135
                 22223333333223433333444444455555555555555566665555554322222222222222222..3555555544443222...2222222 PP

       BUD22 243 eesdssdssesasesesessek.......kkkkkkkkkkkakakkvtss 284
                 e+sd+++++e+          +        ++  +kk+k  ++k++t+s
  EFC35330.1 136 EDSDEDEDEEK----------DlnyyankVSQRHRKKRKLNDSKRSTQS 174
                 22222222222..........1223322211222222222333333333 PP

>> COPI_C  Coatomer (COPI) alpha subunit C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3  11.1    0.0042       6.9      23      84 ..      62     136 ..      35     194 .] 0.50

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0042
                 XX...XXXXXXXXXXXXXXXXX...........XXXXXXXXXXXX......XXXXXXXXXXXXXXXX........XXXXXXXXXXXXXXX CS
      COPI_C  23 ee...eeagagWgddedldlee...........kkeeeededeee......eedeeeggWdvedlel........padldaeaaasaaae 84 
                 e+   +++ ++W dd+  ++++           +++++             +edeee++ d ed +l        +        +++++e
  EFC35330.1  62 EHyyeNSEYEDWDDDDAQKIRNallhgkelytyEDDDS------DyyededDEDEEEDSDD-EDDDLekkgrinsD--------DEEDEE 136
                 22334778899999999999999998876654422222......12333324444444444.55555224444331........222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2363  (0.131798); expected 358.6 (0.02)
Passed bias filter:                      601  (0.0335211); expected 358.6 (0.02)
Passed Vit filter:                       129  (0.00719505); expected 17.9 (0.001)
Passed Fwd filter:                        55  (0.00306766); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.90u 0.37s 00:00:01.27 Elapsed: 00:00:00.51
# Mc/sec: 1133.62
//
Query:       EFC35331.1  [L=478]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.076   12.5   1.6       0.14   11.6   1.6    1.4  1  DUF4607   Domain of unknown function (DUF4607)


Domain annotation for each model (and alignments):
>> DUF4607  Domain of unknown function (DUF4607)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   1.6   7.8e-06      0.14       4      54 ..     205     253 ..     202     267 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 7.8e-06
     DUF4607   4 krllctrqyiiPrspvstasfeeesygearpsptsssetdeapliftvree 54 
                 k+ ++t + +iP+s+ s++s++e++++ + + ++ +s+    +l++  ++e
  EFC35331.1 205 KKWIYTSNNSIPSSETSIQSSKENKEEKKGSASSDTSN--GMDLSMNTQQE 253
                 999******************99988777766666554..34444433333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (478 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1183  (0.0659825); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.46
# Mc/sec: 3106.35
//
Query:       EFC35332.1  [L=111]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.4e-15   55.9   0.0    8.9e-15   55.6   0.0    1.0  1  RNase_T   Exonuclease


Domain annotation for each model (and alignments):
>> RNase_T  Exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.6   0.0     5e-19   8.9e-15       7     109 ..       1     105 [.       1     108 [. 0.95

  Alignments for each domain:
  == domain 1  score: 55.6 bits;  conditional E-value: 5e-19
                 ESSSTTCTTS-EEEEEEEEEETTCC..EEEEEEEEEEEHSSHCSSSHHHHHHHHHCHHHHHTCEBHHHHHHHHHHHHHHHTCCCETT.TCEEEESSHHH CS
     RNase_T   7 ttgldakekdeiieiaaisidggen..eigetfhfyvkptelakltdecteftgitqemldeapsfkevleefkellrklallvahn.aafdvgflraa 102
                 +tgld    d+i+eia i++dg++n  +  ++  +++ +  l++++d+c +++g +++++ +++s+ ++ + ++ +l++ + +va +  a+++g++++ 
  EFC35332.1   1 MTGLDI-DSDHILEIAVIITDGNLNiiAQLDSLIVHQSDSVLDNMNDWCKQHHGDSGLTAAVRKSTLSIQQVEDTVLDFVKHYVASErLAPLAGNSVYC 98 
                 8*****.7*****************88777778889999999********************************************************* PP

                 HHHHHHH CS
     RNase_T 103 dkrilkk 109
                 d++++k+
  EFC35332.1  99 DRLFMKY 105
                 ****986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       460  (0.0256568); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.30s 00:00:00.73 Elapsed: 00:00:00.47
# Mc/sec: 713.95
//
Query:       EFC35333.1  [L=452]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (452 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       457  (0.0254894); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.23s 00:00:00.67 Elapsed: 00:00:00.40
# Mc/sec: 3374.91
//
Query:       EFC35334.1  [L=329]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.03   14.5   0.0      0.076   13.2   0.0    1.7  1  Toprim    Toprim domain


Domain annotation for each model (and alignments):
>> Toprim  Toprim domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   4.3e-06     0.076      37      89 ..      37      94 ..       2     106 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.3e-06
                S...TTEEEEEECTTTHHHHHH.HHHHHHHHSEEEEECSSSHHHHHHHHHHHHHHT.H CS
      Toprim 37 t...efkpvyeeiedkkkvlka.lkelakradeiilatDpDreGeaiawellevlk.e 89
                +   ++ +++++ +   +v k+ +++la++ +  i a D D+e  +i w+l++ ++  
  EFC35334.1 37 ShylKYIKEFQNDPLLDNVKKMkFEMLASKIESHISAGDDDVESLKIVWKLFTKFYdV 94
                1444444444444444444444799***************************988842 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       842  (0.046963); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.23s 00:00:00.65 Elapsed: 00:00:00.39
# Mc/sec: 2517.75
//
Query:       EFC35335.1  [L=178]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1422  (0.0793128); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1175.93
//
Query:       EFC35336.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-52  177.8   8.3    1.3e-52  177.6   8.3    1.0  1  CAP_C     Adenylate cyclase associated (CAP) C terminal
    5.1e-05   23.0   5.4    8.3e-05   22.3   5.4    1.4  1  TBCC      Tubulin binding cofactor C
  ------ inclusion threshold ------
       0.12   12.6   0.0       0.21   11.9   0.0    1.4  1  RisS_PPD  Periplasmic domain of Sensor histidine kinase RisS


Domain annotation for each model (and alignments):
>> CAP_C  Adenylate cyclase associated (CAP) C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  177.6   8.3   2.1e-56   1.3e-52       3     154 ..       3     155 ..       1     158 [. 0.98

  Alignments for each domain:
  == domain 1  score: 177.6 bits;  conditional E-value: 2.1e-56
       CAP_C   3 pklele.gnkwlvenqennkeieieetelkqsvyifkCknstiqikgKvnaitldnckkvsvvvdsvvSsvevincksvkvqvlgkvptisiDktdgvq 100
                 +klel+ gnkwlve+q+++++++i++t ++qsv+++kC+nst+ ++gKvn it+d+c++++++++s +S ++vinck+v+vqv++++p + i+kt +++
  EFC35336.1   3 AKLELNsGNKWLVEYQKGQQDLTINSTAIQQSVVVYKCENSTLVVRGKVNGITIDSCSNFNIIFESSISPLDVINCKRVQVQVEKTTPAVIINKTANIK 101
                 79999978******************************************************************************************* PP

       CAP_C 101 iyLskesldteivtsksseinvsvpkeedgdykElpipeqfktkikkgklvtev 154
                 ++Lskesl+te+v+s s+e+nv +p+++ +d+ Elpipe ++t++ kgkl+tev
  EFC35336.1 102 VFLSKESLHTEFVSSLSNEMNVYIPTQDGEDTIELPIPETLTTRVVKGKLETEV 155
                 **************************9999**********************98 PP

>> TBCC  Tubulin binding cofactor C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   5.4   1.4e-08   8.3e-05      21      88 ..      33     103 ..      21     128 .. 0.58

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 1.4e-08
                 S-EEEES-BS-EEE-.---SS-EEEES-BS-EEE---S..EEEEES-BS-EEE---SSEEEE.ES-BSEEEE CS
        TBCC  21 ssvtiddcknctivl.gpvsgsvfiedcenctivvacr..qlrihdctnvdvylltksrPii.edskgirfa 88 
                 +sv + +c+n+t+v+ g+v+g + i++c+n +i++ +    l + +c++v+v +  ++ ++i  +  +i+++
  EFC35336.1  33 QSVVVYKCENSTLVVrGKVNG-ITIDSCSNFNIIFESSisPLDVINCKRVQVQVEKTTPAVIiNKTANIKVF 103
                 455555666665555333333.55566666555555431145555566666655555555444444455443 PP

>> RisS_PPD  Periplasmic domain of Sensor histidine kinase RisS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   3.5e-05      0.21      20      75 ..     103     159 ..      84     161 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3.5e-05
    RisS_PPD  20 isadpelrvaLlkeLaekegirilprepsDkie.pleddrltrliaeevrerlgekt 75 
                   ++++l ++++++L+++ ++ i  ++ +D+ie p++++ +tr ++ ++++++g+k+
  EFC35336.1 103 FLSKESLHTEFVSSLSNEMNVYIPTQDGEDTIElPIPETLTTRVVKGKLETEVGSKA 159
                 56789999************************967888889999********99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       765  (0.0426683); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.42
# Mc/sec: 1152.82
//
Query:       EFC35337.1  [L=243]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      6e-17   61.4   0.0    7.6e-17   61.1   0.0    1.1  1  Aminotran_3  Aminotransferase class-III


Domain annotation for each model (and alignments):
>> Aminotran_3  Aminotransferase class-III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.1   0.0   4.3e-21   7.6e-17       9     214 ..      58     243 .]      51     243 .] 0.92

  Alignments for each domain:
  == domain 1  score: 61.1 bits;  conditional E-value: 4.3e-21
                  SCEEEEEEEBTEEEETTS-EEEESSHHHHTTTT-BT-HHHHHHHHHHHTT-S---TTTCEEHHHHHHHHHHHHHCT-..SEEEEESSHHHHHHHHHHH CS
  Aminotran_3   9 lllvitkaeGvyltdvdgkrylDlvssiavvnlGhahPkvvkavkeqaaklshvsfgaltnepalklaekllklapkgldkvflansGseAvetAlKl 106
                   +l++++a+G   td d+ +++D+  +    ++Gh+   vv+ v++q+++    +   l ne+a+ + + l k ++       +a s ++A+   l++
   EFC35337.1  58 HPLFVKQAKGGHFTDLDDVKFIDFCLGDTGSMTGHSPDVVVDFVSKQLNNGITYM---LPNENAIWVGDDLKKRFGL--PYWQVAVSATDANRFTLRI 150
                  4699***********************************************5555...9***************999..777788899********** PP

                  HHHHHHHTSHCTT-EEEEETTT---SSHHHHHHSS--TTTTTTCTTB-TSEEEE-TTBGGGTB-HHHHHHHHHHHHHHHH.CHTCCCEEEEEE-SCET CS
  Aminotran_3 107 arkyarekkatektkiiafkgafHGrtlgalsvtgskkkyktlfgpflpevvrlkypdeevlkeneeeeaalleeleale.kkkkdevaAvivEpiqg 203
                  ar+       t+++ki+ f+ ++HG +  a  + ++ +++ +++ ++  +    + + + v+++n+         +eale + +  +vaAv+ Ep   
   EFC35337.1 151 ARH------ITKRPKILVFNYCYHGTVDEAFVTLAD-DGVTAECRATNIGPQTNPTNTTKVVEFND---------VEALErALAPGDVAAVLCEPAMT 232
                  ***......9******************99988888.99999999998888889999999999999.........99999788999************ PP

                  TTTSEB--CCH CS
  Aminotran_3 204 egGvvvaspef 214
                  + G+v + ++f
   EFC35337.1 233 NIGIVLPHQDF 243
                  *****999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       437  (0.0243739); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1662.00
//
Query:       EFC35338.1  [L=489]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.1e-07   30.0   0.0    1.7e-06   28.8   0.0    1.7  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
      0.025   13.0   0.0      0.035   12.5   0.0    1.2  1  DUF505          Protein of unknown function (DUF505)
      0.074   12.0   0.0       0.21   10.6   0.0    1.6  2  Glucokinase     Glucokinase


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0   2.9e-10   1.7e-06       2      94 ..      91     178 ..      90     180 .. 0.77

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 2.9e-10
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....E.T-B--EEE...........---TT-E....EEEE-..B-TEEE--B.-SS-EEE CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekes.eeGGelelyekdk.eavkikpkkgrl....vlFesdellpHevlpvtkggeRls 90 
                     ++l y+eg++++ H D+    e+++++ +t+++ L    s ++GGe+ + + d+ e++++  k+g+       F++d+   H+v + t+g  Rl+
      EFC35338.1  91 KLLLYEEGGHFDFHRDT----EKEDKMFATLVVQLP---SlYSGGEIIVQHADSeETYEF-AKEGSSkpffFSFYCDCN--HKVAKLTSG-YRLC 174
                     6889************7....45589*********3...56********76666555555.677776554466666666..*****9886.9999 PP

                     EEEE CS
  2OG-FeII_Oxy_3  91 ltgw 94 
                     l+++
      EFC35338.1 175 LVYN 178
                     8765 PP

>> DUF505  Protein of unknown function (DUF505)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   5.9e-06     0.035     280     344 ..     350     413 ..     306     428 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.9e-06
      DUF505 280 ialeeeevevLkaIdelwkkaeenpevlPtlkeikrelidrkikeYkellekYGRkleempkkke 344
                 +ale  e e Lk ++++w ++e++p+ l t+   +  ++  k    k+l+ kY  kl++++  k+
  EFC35338.1 350 LALEIGETESLKELENMWTRYEQDPSLLDTVTDFVTRFLRNK-YFKKTLVTKYVIKLNNTELAKD 413
                 678889999**********************99988887333.233789********99766555 PP

>> Glucokinase  Glucokinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.22   1.3e+03      70      87 ..      52      69 ..      48      75 .. 0.78
   2 ?   10.6   0.0   3.5e-05      0.21     135     180 ..      75     120 ..      69     131 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.22
  Glucokinase 70 develtNlpWviseeela 87
                  ++++tN +W+  +++l 
   EFC35338.1 52 SQFRITNQHWKQYIDNLV 69
                 6899******97776665 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 3.5e-05
  Glucokinase 135 aGTGLGvallipekerrvvlasEGGhvdfapeseeevelleilrkk 180
                  +G G+  +++++++  +  l  EGGh df   +e+e ++++ l  +
   EFC35338.1  75 PGLGIHSSVVVRNSLYKLLLYEEGGHFDFHRDTEKEDKMFATLVVQ 120
                  7777778888888888889********************9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       608  (0.0339115); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 3178.57
//
Query:       EFC35339.1  [L=474]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.2e-46  153.5  17.1    3.4e-13   49.1   0.3    8.9 10  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   1.3e-09   2.3e-05       6      48 ..      93     135 ..      86     136 .. 0.83
   2 !   14.0   0.0   1.7e-06     0.031      19      43 ..     131     155 ..     128     161 .. 0.85
   3 ?    1.6   0.0     0.013   2.4e+02       1      23 [.     163     185 ..     163     189 .. 0.91
   4 !    7.3   0.0   0.00022         4      19      36 ..     237     254 ..     229     266 .. 0.78
   5 !   42.1   0.1   2.9e-15   5.1e-11       2      49 .]     267     314 ..     266     314 .. 0.98
   6 !   49.1   0.3   1.9e-17   3.4e-13       1      49 []     291     339 ..     291     339 .. 0.99
   7 !   39.5   0.2   1.9e-14   3.4e-10       1      49 []     316     386 ..     316     386 .. 0.98
   8 !   22.1   0.0     5e-09   8.9e-05       1      49 []     363     412 ..     363     412 .. 0.93
   9 !   15.0   0.2   8.5e-07     0.015      12      40 ..     400     428 ..     391     434 .. 0.81
  10 ?   -0.1   0.0     0.042   7.6e+02      26      39 ..     439     452 ..     431     460 .. 0.68

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 1.3e-09
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 ++ + k+g +l+ ls++L nD+ +vlkAv++++  +  a++++
  EFC35339.1  93 MQFIGKDGGVLRRLSKSLINDRSFVLKAVEICPVDIFAAPDHF 135
                 456668888***********************97777777665 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 1.7e-06
     DUF4116  19 lseeLknDkeivlkAvkqngtalsy 43 
                 +++ ++nD+eiv+ A++++  +l+ 
  EFC35339.1 131 APDHFQNDREIVITALRNDAWILEN 155
                 6999**************9988765 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.013
     DUF4116   1 DrEivleavkkngsalkylseeL 23 
                 D+Ei   + +++  al ++se+L
  EFC35339.1 163 DEEIFELVARTDLAALMFASERL 185
                 89999999999999*******99 PP

  == domain 4  score: 7.3 bits;  conditional E-value: 0.00022
     DUF4116  19 lseeLknDkeivlkAvkq 36 
                 + e+L+nD  +++k  ++
  EFC35339.1 237 VYERLRNDTSFIMKMFRK 254
                 689**********97765 PP

  == domain 5  score: 42.1 bits;  conditional E-value: 2.9e-15
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 rEi++  vk ng++l++l+ee++ D+eiv  A+++++++l yase +r
  EFC35339.1 267 REIAMRMVKMNGLSLQFLNEEYRDDFEIVTCALNNHCHSLAYASERIR 314
                 9********************************************887 PP

  == domain 6  score: 49.1 bits;  conditional E-value: 1.9e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D Eiv+ a+ +++ +l y+se++++D+++++kA+++++ ++syas++Lr
  EFC35339.1 291 DFEIVTCALNNHCHSLAYASERIRSDRDFMKKAIEKYSVVYSYASDDLR 339
                 88**********************************************8 PP

  == domain 7  score: 39.5 bits;  conditional E-value: 1.9e-14
     DUF4116   1 DrEivleavkkngsalkylseeLkn......................DkeivlkAvkqngtalsyaseeLr 49 
                 Dr+++++a++k++ ++ y+s++L+n                      ++++v++Avk++   l ++++eL+
  EFC35339.1 316 DRDFMKKAIEKYSVVYSYASDDLRNndvelalisirggnwipvehemNRQVVKEAVKKSALQLTRVPDELK 386
                 9********************************************************************97 PP

  == domain 8  score: 22.1 bits;  conditional E-value: 5e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt.alsyaseeLr 49 
                 +r++v+eavkk  + l+ +++eLk+   ++ ++++     +l+y+ +eLr
  EFC35339.1 363 NRQVVKEAVKKSALQLTRVPDELKSCAPFMFEIINETTEpILKYITNELR 412
                 79*********9999999*****************8885389*******8 PP

  == domain 9  score: 15.0 bits;  conditional E-value: 8.5e-07
     DUF4116  12 ngsalkylseeLknDkeivlkAvkqngta 40 
                    +lky+ +eL+   ++vl+A+++++++
  EFC35339.1 400 TEPILKYITNELRFSQDFVLEAIRISSNN 428
                 4679********************98853 PP

  == domain 10  score: -0.1 bits;  conditional E-value: 0.042
     DUF4116  26 DkeivlkAvkqngt 39 
                 +ke+++k  +  g+
  EFC35339.1 439 NKEFAKKVAQLTGY 452
                 77777777666664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.28s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 2883.41
//
Query:       EFC35340.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2050  (0.11434); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1331.91
//
Query:       EFC35341.1  [L=174]
Description: hypothetical protein NAEGRDRAFT_77005, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-55  188.8   0.0    1.3e-55  188.7   0.0    1.0  1  Actin     Actin
     0.0062   15.4   0.0      0.007   15.2   0.0    1.2  1  MreB_Mbl  MreB/Mbl protein


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  188.7   0.0   1.4e-59   1.3e-55       2     167 ..       3     173 ..       2     174 .] 0.93

  Alignments for each domain:
  == domain 1  score: 188.7 bits;  conditional E-value: 1.4e-59
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea....klyvgde.alt.krpelevrspvedGvvedwdaveelwehvlkeelkvdpee 94 
                 +e sa+V+DnGs++++aG++g ++P++v+psl+++p ++k+++     ++vgde +++ +++   vr+p+e+Gvv++w+ +e++w+hv+ + l+vd e+
  EFC35341.1   3 QEYSAIVFDNGSGSIKAGFSGCENPQVVFPSLIASPLKSKESEnikeIYLVGDEaKIDsRKNVRMVRYPIEHGVVTNWEGMEQIWRHVFSQ-LQVDCEN 100
                 6889******************************8888776657777899****666744666679**********************987.******* PP

       Actin  95 hpllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkk 167
                 hp+llt+pp np+++rek++Ei+fE+f++p++y++  avls+fa+g++tg+v+DsG++vt +vp+++  +L++
  EFC35341.1 101 HPVLLTQPPCNPKQNREKMTEIMFETFRIPSMYVSIPAVLSLFATGRTTGIVLDSGDGVTNIVPIFESHALEY 173
                 *******************************************************************999976 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   7.8e-07     0.007      35     104 ..      46     111 ..      28     163 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 7.8e-07
                 TT--EEEESHHHHTTTTS-GTTEEEE-.SEETTEESSHHHHHHHHHHHHHHHHTSS-SS--EEEEEE-SS- CS
    MreB_Mbl  35 ktkkvlavGeeAkkmlgktpgnikavr.PlkdGviadlevaeellkyfikkvkkkkslskprvvicvPsgi 104
                 + k+++ vG+eAk     +++n+++vr P+++Gv+++ e  e++ ++++++++ +  +++  v+++ P + 
  EFC35341.1  46 NIKEIYLVGDEAKI---DSRKNVRMVRyPIEHGVVTNWEGMEQIWRHVFSQLQVD--CENHPVLLTQPPCN 111
                 3688999*****95...57899999988***********************9986..56666666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       304  (0.0169558); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.29s 00:00:00.73 Elapsed: 00:00:00.46
# Mc/sec: 1128.72
//
Query:       EFC35342.1  [L=133]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       210  (0.0117129); expected 358.6 (0.02)
Passed bias filter:                      183  (0.0102069); expected 358.6 (0.02)
Passed Vit filter:                         7  (0.000390429); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 819.68
//
Query:       EFC35343.1  [L=209]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.04   13.7   0.0       0.39   10.5   0.0    2.0  2  Phage_integrase  Phage integrase family


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0     0.017     3e+02      27      49 ..      40      62 ..      18      69 .. 0.72
   2 ?   10.5   0.0   2.2e-05      0.39      91     153 ..     117     178 ..     101     193 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.017
                     HHHHHHHT--HHHHTT-BGGGEE CS
  Phage_integrase 27 lellyetGlRisEllsLrvkdld 49
                     l + ++  +R ++l+ L+++ ++
       EFC35343.1 40 LVIGFRLLARPGDLCDLSWSSVK 62
                     44555667899********9886 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 2.2e-05
                      CTTTSBSSBETTSSB--HHHHHHHHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHH CS
  Phage_integrase  91 aeksellfaskrgkplsrqtvrkafkraveeagiekpltpHtlRhsfataLleagvdlrvvqk 153
                      +++++ lf  +++  l + +++ ++k+a    g+  ++++H+ R  +at+L  +g++   ++ 
       EFC35343.1 117 KSPDSPLFSWADDLYLDTIDLSNIIKTAMSSIGVF-HTSGHSARIGAATKLTSKGISEVIIKT 178
                      55555666666666788889999**********99.*******************98766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       451  (0.0251548); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.35s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1199.73
//
Query:       EFC35344.1  [L=141]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-06   28.5   2.6    2.1e-06   27.8   0.0    2.4  2  Ribosomal_S30  Ribosomal protein S30


Domain annotation for each model (and alignments):
>> Ribosomal_S30  Ribosomal protein S30
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.8   0.0   1.2e-10   2.1e-06       4      33 ..       6      35 ..       4      57 .. 0.78
   2 ?   -0.2   0.8     0.067   1.2e+03      25      41 ..     111     127 ..      95     138 .. 0.65

  Alignments for each domain:
  == domain 1  score: 27.8 bits;  conditional E-value: 1.2e-10
                   X-STTTTHHHHHS-------------THHH CS
  Ribosomal_S30  4 GsLarAGKVrnqTPKveKqekkKkptGRak 33
                   G+Lar GKV+ qTP+veK      + G ak
     EFC35344.1  6 GGLARSGKVKYQTPRVEKTSDSSYHGGCAK 35
                   9*****************965554555554 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.067
                    -----THHHHHHHHHHH CS
  Ribosomal_S30  25 kKkptGRakkRlqYnrR 41 
                     Kk+    k R+ Yn  
     EFC35344.1 111 MKKEENILKNRYNYNPN 127
                    44455567778888754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       783  (0.0436723); expected 358.6 (0.02)
Passed bias filter:                      225  (0.0125495); expected 358.6 (0.02)
Passed Vit filter:                         6  (0.000334653); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.29s 00:00:00.71 Elapsed: 00:00:00.45
# Mc/sec: 937.14
//
Query:       EFC35345.1  [L=283]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.023   14.6   0.1      0.031   14.1   0.1    1.1  1  Med18            Med18 protein
       0.15   11.5   0.9       0.22   11.0   0.9    1.2  1  HGTP_anticodon2  Anticodon binding domain of tRNAs


Domain annotation for each model (and alignments):
>> Med18  Med18 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.1   3.4e-06     0.031      44     166 ..      53     225 ..      17     229 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 3.4e-06
                 T......SSSSS--CTTTSEEEEEEGTTSH..............TTSSTGCC......................TS-EEEEEE----SS-SSS-EEEEE CS
       Med18  44 rvfkpkflpgkvnqieqlymklittlndekedyslkviekvkeddsdieakklfseeekve.............erpwtLqisDiPeagknqkvlvrti 129
                 +++++kf++ k ++ e+ y   i+  ++ + +++  + +   e++  i   + f+ e++v+               + + ++ ++P+a+  +k  +  +
  EFC35345.1  53 NAVQVKFEKLKGGKSEKRYKLIINYPKERSGEIKFSISKYCIEKKQVIVLIEDFKLEKSVSlfvgriaaeskifMIELKEEYIGMPIAKVAEKLFAPHC 151
                 34588999999888887776666666665556666666665555666777777777777778888888887666666666899**************** PP

                 EEEEE.....................................ESS-HTHHHHHT..TEEEEEEEEEEEEEEEET CS
       Med18 130 yestlv...................................erkdsllqfledl..GysvineYivkGvrFfhg 166
                 ++ +++                                   +++ ++  +l +l  Gy+  n+++vkG+ F+ g
  EFC35345.1 152 IDKSVTsegcmiinpnlffvdepsqmikttcdmamgmfdpsGNHSHIEPVLHQLsiGYRKYNQIWVKGFSFMNG 225
                 ****99***********************************9999999999876448**************975 PP

>> HGTP_anticodon2  Anticodon binding domain of tRNAs
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.9   2.4e-05      0.22     121     183 ..      21      86 ..       3     105 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 2.4e-05
  HGTP_anticodon2 121 aessqkedeass..esseele.ealaskeerqkevrvlvaatrskksnkrekveqddAqeaaaelv 183
                      ++++++++++ss   s+++++ e ++++e +++ v+v+ ++ ++ ks+kr+k+  +  +e++ e+ 
       EFC35345.1  21 HHNNKNKNSSSSsaLSNRKQQvELEFETEGDENAVQVKFEKLKGGKSEKRYKLIINYPKERSGEIK 86 
                      2333333322223333333334667778889********************997777777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       717  (0.0399911); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1768.31
//
Query:       EFC35346.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
       0.12   12.4  10.6       0.15   12.1  10.6    1.2  1  Asp-B-Hydro_N  Aspartyl beta-hydroxylase N-terminal region
       0.22   11.3  13.0       0.27   11.0  13.0    1.1  1  RR_TM4-6       Ryanodine Receptor TM 4-6
        7.4    5.4  10.6        9.1    5.1  10.6    1.2  1  XRN_M          Xrn1 helical domain
        8.4    5.1  12.0        9.3    5.0  12.0    1.1  1  ALMT           Aluminium activated malate transporter


Domain annotation for each model (and alignments):
>> Asp-B-Hydro_N  Aspartyl beta-hydroxylase N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1  10.6   3.4e-05      0.15      68     168 ..     125     227 ..      91     232 .] 0.74

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.4e-05
  Asp-B-Hydro_N  68 kekstsessvpe..eeaevvaeeeeqlaeekekqkveeevkEqlkkvkeeivvkeeeeegieeepqleeekkllkedsderqeeleagkvkeevEe 161
                      k++s +s+p+   ea ++ ++e  la++++kq+ ++ +    +k   e++ + +++ ++  ++ +++++k +++dsd++  e++++k+k    +
     EFC35346.1 125 LLKTISLNSIPQdiSEAITTRQQELRLAKNESKQRTRQTIANAHQKELGEAISSANKKAKKSSKKVKNNKRKHVESDSDDSSSETDSKKKKVSKKK 220
                    335555688888434444455666678999999999999999999999999999888888888888888999999999999999998888877776 PP

  Asp-B-Hydro_N 162 slkveet 168
                    + k e  
     EFC35346.1 221 VSKKESK 227
                    6666654 PP

>> RR_TM4-6  Ryanodine Receptor TM 4-6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0  13.0   6.1e-05      0.27      36     160 ..      98     230 ..      68     232 .] 0.50

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 6.1e-05
                 .XXXXXXXXXXXXXXX.XXXXXXXXX....XXXXXXX.XXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXX.XXX.XXXXXXXXXXX CS
    RR_TM4-6  36 geeeeedllsdvfgld.lkkeggqykvva.kkseagL.gDlseteaeespt.....pelkkklaeeeeaeeekeeeeepeaeaeeka.daengekeeke 125
                 +ee+ ++l  + +++d ++k++g  k+   + s +++  D+se  ++++++      e k+++  +++a+ +++e  e  ++a++ka +++++ k++k+
  EFC35346.1  98 TEESLHELAGKYVTFDnTEKNNGILKLLLkTISLNSIpQDISEAITTRQQElrlakNESKQRTR-QTIANAHQKELGEAISSANKKAkKSSKKVKNNKR 195
                 4555566666666666544444444444313333333246666666655557775444444444.4566665555555555554444144444455555 PP

                 XX..........XXXXXXXXXXXXXXXXXXXXXXX CS
    RR_TM4-6 126 kekeeeekeseeeeeekkkkkkakskkkeeaeaee 160
                 k+ e+++++s+ e+ +kkkk  +k+ +k+e+++++
  EFC35346.1 196 KHVESDSDDSSSETDSKKKKVSKKKVSKKESKKKH 230
                 55555555555555555544444444444444444 PP

>> XRN_M  Xrn1 helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1  10.6     0.002       9.1      66     161 ..     136     227 ..      92     232 .] 0.48

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.002
       XRN_M  66 eklvslvgkveekifrkrkeredrkekklakeeeaskedaaneeaavaeeklseskvaksaeaeaeaeaeaeaeakaekekrekaekeleeseeee 161
                 + + + + + ++++   ++e ++r+++++a+ ++++  +a +++++ a++++++ k +k++++e++++      ++++++k++k+ k++ +++e++
  EFC35346.1 136 QDISEAITTRQQELRLAKNESKQRTRQTIANAHQKELGEAISSANKKAKKSSKKVKNNKRKHVESDSDD----SSSETDSKKKKVSKKKVSKKESK 227
                 334444555555555555555555555555554444444444444444444333333333333333333....33333333333333333333222 PP

>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0  12.0    0.0021       9.3     287     424 ..      82     225 ..      49     232 .] 0.52

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0021
        ALMT 287 apeelrkkfkeelqrvslesakvlrelaesvkkmkklsk.veellkev..kvaaeeLqskl.dskskLlvnsekweaakkkekaeeveekkeeekeses 381
                   +e r+ +   l +++ es + l  +     +++k++   + llk++  ++  +++ +++   +++L ++ ++ ++ ++++ a++++++  e+ +s +
  EFC35346.1  82 HDSEARQSLARGLLTLTEESLHELAGKYVTFDNTEKNNGiLKLLLKTIslNSIPQDISEAItTRQQELRLAKNESKQRTRQTIANAHQKELGEAISSAN 180
                 556777777777777777777777777777777777777445555544113445677777755666777777765555555555555544444333332 PP

        ALMT 382 kkeea.eaveeaeseseksllkeskrslklskkesapaee.slee 424
                 kk ++ +++ +++++++ ++ ++ ++s + skk+++++++ s++e
  EFC35346.1 181 KKAKKsSKKVKNNKRKHVESDSDDSSSETDSKKKKVSKKKvSKKE 225
                 222221111222222222222222222222222222221112222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3247  (0.181103); expected 358.6 (0.02)
Passed bias filter:                      655  (0.036533); expected 358.6 (0.02)
Passed Vit filter:                       154  (0.00858944); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 1358.57
//
Query:       EFC35347.1  [L=207]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00012   22.7   0.0    0.00018   22.1   0.0    1.3  1  VWA_2     von Willebrand factor type A domain
    0.00018   21.8   0.0    0.00025   21.4   0.0    1.3  1  VWA       von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   0.0     2e-08   0.00018       2     106 ..      21     130 ..      20     133 .. 0.82

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 2e-08
       VWA_2   2 vfvlDtSgSmrngdygptrleaakdaveallksl....pgd...rvglvtfsd...gpevli.pltkdkakilnalrnleak...gggtnlaaaLqlar 86 
                  f+lD + Sm +       ++ ak+ ++++lk+     +++   r++ v ++d   ++  +i p+t+  + i++a+ +   +   + + ++a +Lq++ 
  EFC35347.1  21 CFLLDITSSMKTW------MDSAKSVISKVLKEVasknQEVktiRYAFVGYADiddKVPFVIhPFTDQVEVIEKAIADCPLMygyDIAEDVAGGLQKVV 113
                 69*********98......9999999999999554444333556999999999865566555378999**********9988888899*********** PP

       VWA_2  87 kalkkrrkgekrvivlitDg 106
                 ++ ++     +rv+++i+D+
  EFC35347.1 114 DLDWNSF---TRVLIHIADA 130
                 9999766...9*******96 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.0   2.8e-08   0.00025       1      90 [.      19     114 ..      19     151 .. 0.78

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 2.8e-08
                 EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHTB...TTTTEEEEEEEESSS....EEEEEETTSHCHHHHHHHHHHTG..SGGGGSSC-HHHHHHHHHH CS
         VWA   1 DivfvlDgSgsmgeenfekvkefikklveklev...gpegtrvglvqfsse....vktefslndysskeellsalnnl..kysgggttntgkalkyale 90 
                 D+ f+lD  +sm +  ++++k+ i+k+++++ +     +++r+++v +++     + ++ +++d  + e + +a+ +   +y +    +++ +l+++++
  EFC35347.1  19 DLCFLLDITSSM-KTWMDSAKSVISKVLKEVASknqEVKTIRYAFVGYADIddkvPFVIHPFTD--QVEVIEKAIADCplMYGYDIAEDVAGGLQKVVD 114
                 99**********.88888**************6555667888******9665455666667777..5599999**997556666666666666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       917  (0.0511462); expected 358.6 (0.02)
Passed bias filter:                      658  (0.0367003); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1227.12
//
Query:       EFC35348.1  [L=570]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-62  207.6 240.7    4.3e-06   27.0   8.4   15.4 15  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.2   1.2    0.0063   1.1e+02      23      32 .]       1      10 [.       1      10 [. 0.97
   2 !   21.0   9.7   1.8e-08   0.00032       5      32 .]      23      49 ..      20      49 .. 0.92
   3 !   26.1   7.1   4.4e-10   7.8e-06       3      32 .]      60      88 ..      58      88 .. 0.89
   4 !   18.5  11.7   1.1e-07    0.0019       5      32 .]     101     127 ..      93     127 .. 0.89
   5 !   21.0   9.7   1.8e-08   0.00032       5      32 .]     140     166 ..     137     166 .. 0.92
   6 !   27.0   8.4   2.4e-10   4.3e-06       3      32 .]     177     205 ..     175     205 .. 0.92
   7 !   24.9  11.0   1.1e-09     2e-05       5      32 .]     218     244 ..     210     244 .. 0.89
   8 !   18.1   9.5   1.5e-07    0.0026       4      32 .]     256     283 ..     252     283 .. 0.91
   9 !   23.9   6.9   2.3e-09     4e-05       4      32 .]     295     322 ..     291     322 .. 0.91
  10 !   24.1   9.3   1.9e-09   3.5e-05       5      32 .]     335     361 ..     331     361 .. 0.91
  11 !   20.4  10.3   2.8e-08    0.0005       4      32 .]     373     400 ..     370     400 .. 0.91
  12 !   15.8   9.9   7.6e-07     0.014       5      32 .]     413     439 ..     409     439 .. 0.90
  13 !   17.0  10.4   3.2e-07    0.0057       5      32 .]     452     478 ..     449     478 .. 0.89
  14 !   21.0   6.7   1.8e-08   0.00033       4      32 .]     489     522 ..     487     522 .. 0.90
  15 !   14.3   7.9   2.2e-06      0.04       1      24 [.     540     561 ..     540     568 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.0063
       EGF_2 23 CdsgyqGktC 32
                C +gy+G++C
  EFC35348.1  1 CLDGYYGNDC 10
                99******** PP

  == domain 2  score: 21.0 bits;  conditional E-value: 1.8e-08
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyqGktC 32
                ++ C+g+G C++++ +C+C++ ++G++C
  EFC35348.1 23 SSVCSGQGRCISPN-NCSCSNEHYGNDC 49
                578********999.8************ PP

  == domain 3  score: 26.1 bits;  conditional E-value: 4.4e-10
       EGF_2  3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                ++++ C+ghGtC  ++ +C+C +gy+G +C
  EFC35348.1 60 TNGSVCSGHGTCLLPN-NCSCLAGYSGSDC 88
                56899*******8566.8************ PP

  == domain 4  score: 18.5 bits;  conditional E-value: 1.1e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C++++ +C+C  gy+G +C
  EFC35348.1 101 SSVCSGNGNCIAPN-NCSCTYGYYGSNC 127
                 789********999.8************ PP

  == domain 5  score: 21.0 bits;  conditional E-value: 1.8e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C++++ +C+C++ ++G++C
  EFC35348.1 140 SSVCSGQGRCISPN-NCSCSNEHYGNDC 166
                 578********999.8************ PP

  == domain 6  score: 27.0 bits;  conditional E-value: 2.4e-10
       EGF_2   3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++++ C+ghGtC +++ +C+C +gy+G +C
  EFC35348.1 177 TNGSVCSGHGTCLSPN-NCSCLAGYSGSDC 205
                 56899********999.8************ PP

  == domain 7  score: 24.9 bits;  conditional E-value: 1.1e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C++++ +C+C sgy+G+ C
  EFC35348.1 218 SSVCSGNGYCIAPN-NCSCTSGYYGNEC 244
                 789********999.8************ PP

  == domain 8  score: 18.1 bits;  conditional E-value: 1.5e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C ghG C++++ +C+C++ ++G++C
  EFC35348.1 256 SGSVCFGHGDCISPN-NCSCSNEHYGNDC 283
                 4899********999.8************ PP

  == domain 9  score: 23.9 bits;  conditional E-value: 2.3e-09
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C+  G Cv+++ +C+C +gy+G++C
  EFC35348.1 295 SGSVCSSYGRCVSPN-NCSCLAGYYGNDC 322
                 4899********999.8************ PP

  == domain 10  score: 24.1 bits;  conditional E-value: 1.9e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+ghG C++++ +C+C +gy+G++C
  EFC35348.1 335 ASACSGHGGCISPN-NCSCLDGYYGNDC 361
                 678********999.8************ PP

  == domain 11  score: 20.4 bits;  conditional E-value: 2.8e-08
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s+++C ghG C++++ +C+C +gy+G++C
  EFC35348.1 373 SGSACYGHGGCISPN-NCSCLDGYYGNDC 400
                 5899********999.8************ PP

  == domain 12  score: 15.8 bits;  conditional E-value: 7.6e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C ghG C++++ +C+C++gy G +C
  EFC35348.1 413 ASACYGHGGCISPN-NCSCSAGYNGYDC 439
                 678********999.8**********99 PP

  == domain 13  score: 17.0 bits;  conditional E-value: 3.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+g G C+ +   C+C+sgy+G +C
  EFC35348.1 452 ASACSGKGRCDFFD-HCSCQSGYYGSHC 478
                 578*******9788.8************ PP

  == domain 14  score: 21.0 bits;  conditional E-value: 1.8e-08
       EGF_2   4 s.deiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                 + ++ C+ghG+C +++  C+C     +  ++G++C
  EFC35348.1 489 NaSSVCSGHGQCTDLN-ICVCdniagKGYWTGADC 522
                 45789*******9888.****************** PP

  == domain 15  score: 14.3 bits;  conditional E-value: 2.2e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCd 24 
                 C a +++C+g+G+C++++ qC C 
  EFC35348.1 540 CNA-STTCSGNGYCNELE-QCTCY 561
                 777.599***********.****3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (570 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                       90  (0.0050198); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.28s 00:00:01.08 Elapsed: 00:00:00.49
# Mc/sec: 3484.49
//
Query:       EFC35349.1  [L=296]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0003   20.7   0.0        4.2    7.6   0.0    3.8  3  NHL       NHL repeat
  ------ inclusion threshold ------
        1.5    9.3   6.7        3.7    8.1   6.7    1.6  1  PHtD_u1   Unstructured region on Pneumococcal histidine triad


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0   0.00047       4.2       1      21 [.     146     167 ..     146     171 .. 0.91
   2 !    7.0   0.0    0.0007       6.3      11      23 ..     208     220 ..     204     223 .. 0.86
   3 ?    1.1   0.0     0.052   4.6e+02       1      17 [.     260     275 ..     260     283 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00047
                 BSSEEEEEEE.TTTEEEEEECC CS
         NHL   1 fnyPhGvavd.snGdiyVaDse 21 
                 + +P Gv +d s++ +y+ D++
  EFC35349.1 146 LTSPGGVYLDeSTNILYILDNG 167
                 568*****************75 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0007
                 TTTEEEEEECCCT CS
         NHL  11 snGdiyVaDsenh 23 
                 ++G +y+aD++n+
  EFC35349.1 208 NGGIFYIADTGNN 220
                 799********97 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.052
                 BSSEEEEEEETTTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyV 17 
                 +++P++++ +s+G i +
  EFC35349.1 260 LSSPTSITFSSDGMI-I 275
                 678******766644.4 PP

>> PHtD_u1  Unstructured region on Pneumococcal histidine triad protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   6.7   0.00041       3.7       2      43 ..      30      70 ..      29      72 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00041
     PHtD_u1  2 lsnSRtyntsstnwvpsqPtntrlSnNsnlnsqp.sQgedidS 43
                l++S t nt  +  +++    t + nN+n+   + s g+ idS
  EFC35349.1 30 LASSNTQNTTTSTIIKTT--TTTTANNYNIKIVAgSYGNTIDS 70
                789999999999999985..599******98655279****99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       855  (0.0476881); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1874.32
//
Query:       EFC35350.1  [L=576]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-37  128.4   1.0    6.3e-37  127.7   1.0    1.3  1  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  127.7   1.0   3.5e-41   6.3e-37       1     208 [.     289     536 ..     289     537 .. 0.81

  Alignments for each domain:
  == domain 1  score: 127.7 bits;  conditional E-value: 3.5e-41
      DUF563   1 nnygHwlvdvlprlllleqlvlddd...drilvpalaspqpfqrellkllgi.rpekrikveldepvhveklivpvppr......ssggfqgallp... 86 
                 n++ H+++d+++++l++e++ l+++   +++l +++++p +f+++++  + + rp  + +   +++v++e++i++++++      +       +l    
  EFC35350.1 289 NMF-HSMTDFFATYLMIEMFQLNSSqvqIVLLDDHYDGPFDFLWNSV--FSLkRPMMKASQFNNSTVRFERAIFQHAGYathflsH-------VLDfdk 377
                 689.*********************764444488989999***9999..888335555544467***************5555553.......333445 PP

      DUF563  87 ..............klrdrlrerlnlekr..kkp...trvlyisR...lkag......sRrilNeeevlkllpkrg.......fevvdpeslsfeeqik 150
                                +++r+ + l+++kr  k +    + l+isR    k+g      +R+i+Ne+e+++ ++ +        +e +d++sls+ eqi+
  EFC35350.1 378 qdprmchskiplvsSFANRIIQLLGIKKRemK-KgdmVKGLFISRkpyVKNGinhqfmGRQISNEDELMAFFRMHPlhstnftIEKIDFASLSLVEQIQ 475
                 55558888999999**************9962.24688999****8773333666777***********5555555555554499************** PP

      DUF563 151 lfssakvivgphGsgltnliFmpp.gttvielvppnrldns..fenlaallglkyayvlge 208
                  ++++++++g+hG+glt+++++p+  ++v+e++ ++  + +  fe+l+ ++g++y ++ ++
  EFC35350.1 476 KVHNSDFLIGYHGAGLTHSLWLPEdSSGVLEIWKSAFSKSWrcFEQLTLWKGNYYDLWSNT 536
                 **********************8857******99977766677************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       538  (0.0300073); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 4054.46
//
Query:       EFC35351.1  [L=422]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (422 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       966  (0.0538792); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 2631.03
//
Query:       EFC35352.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      286  (0.0159518); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1304.30
//
Query:       EFC35353.1  [L=227]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       578  (0.0322383); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1442.96
//
Query:       EFC35354.1  [L=191]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.012   15.7   1.2      0.019   15.1   1.2    1.3  1  Caenor_Her-1  Caenorhabditis elegans Her-1
      0.034   14.0   0.6      0.049   13.5   0.6    1.3  1  DarT          ssDNA thymidine ADP-ribosyltransferase, DarT


Domain annotation for each model (and alignments):
>> Caenor_Her-1  Caenorhabditis elegans Her-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   1.2   2.1e-06     0.019      35      88 ..      32      85 ..      25     121 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.1e-06
                  HHHHHHHHTSS-GGG---GGGGGGGGGGGCTTTCCCHHHHHHHHHHCT-TTS-H CS
  Caenor_Her-1 35 ykClqkelfaeeeekrlelddsvCCqvfkkdqndpkrrCekiCktvlesPslda 88
                  + C+  + +  +++  ++++ + CCq+ +  + +  +r ++ C+t+++ Ps  +
    EFC35354.1 32 FVCINIDYYYVNDPEAVKFKMVNCCQITSLQNCETSSRGTTFCRTTVKYPSNLQ 85
                  5799999999999999**********************************9432 PP

>> DarT  ssDNA thymidine ADP-ribosyltransferase, DarT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.6   5.4e-06     0.049      60     124 ..     116     175 ..      82     187 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.4e-06
        DarT  60 vpfYfaprspmlyriergnhaeykgedivvLvidleilasgercvftdgnaaasg.tefrngledl 124
                 +pfYf+p+++ ly++++++ +        +L ++++ +  ++ +  t++  ++s+ +  + +l+++
  EFC35354.1 116 APFYFNPNNVSLYEYYSEDYP-----RNLWLDFNCRAM-VEYVVNGTNSELTNSFtSSNYPNLASF 175
                 7***************99954.....667788888888.566666666666666666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       979  (0.0546043); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1239.71
//
Query:       EFC35355.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0045   16.8   2.6      0.011   15.5   0.7    2.3  3  Phage_GP20     Phage minor structural protein GP20
  ------ inclusion threshold ------
      0.014   15.0   0.0      0.056   13.1   0.0    1.8  1  PI3K_P85_iSH2  Phosphatidylinositol 3-kinase regulatory subun
      0.024   14.4   0.1      0.048   13.5   0.1    1.5  1  SKA2           Spindle and kinetochore-associated protein 2


Domain annotation for each model (and alignments):
>> Phage_GP20  Phage minor structural protein GP20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0     0.094   5.6e+02      28      46 ..      58      76 ..      37      87 .. 0.75
   2 !   15.5   0.7   1.9e-06     0.011       3      89 ..     148     235 ..     146     242 .. 0.88
   3 ?   -4.1   0.0         2   1.2e+04      92     106 ..     280     294 ..     278     303 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.094
  Phage_GP20 28 dtlkeqlkdrdkqLedLkk 46
                 + k+++++ d++L dL++
  EFC35355.1 58 SEHKKKIEEYDNKLGDLEG 76
                5678999999999999986 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 1.9e-06
  Phage_GP20   3 ikkvmkaengkdit..kakldeveeerdtlkeqlkdrdkqLedLkkkakdneeLqkqieelqaknkkakaeyeakiadlkldnaielaL 89 
                 +++vm + +g+++    ++l +v  + +  ++  +++ + L+ +k++ k  e+L+k+i++ ++++ ++ +++    +++++ +ai+l +
  EFC35355.1 148 YDSVM-EIDGNVLVedVEALVNVHVDPQVAQKGWEEKRTLLKAIKEVEKKYETLEKDIKTNKKDFVQKRETSLVSWYNVAFGSAISLLI 235
                 78999.888888864566777888888889999999*********************************************99999876 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 2
  Phage_GP20  92 akaknekavkalldk 106
                 +++++ k++ a+ d+
  EFC35355.1 280 QNFRDSKILAAIVDV 294
                 788999999999885 PP

>> PI3K_P85_iSH2  Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   9.3e-06     0.056      33     118 ..      29     211 ..      23     219 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 9.3e-06
  PI3K_P85_iSH2  33 ydqlkeeynkiseeiqlkrqaleaFneaikmFeeqiklqekfskea......q........................................... 79 
                    y + +++++ki    +l + a   F + +k F e+ k +e++ ++       +                                           
     EFC35355.1  29 YARRYKKWKKIG---KLIKFASASFHNCVKFFSEHKKKIEEYDNKLgdlegiDtttyvgerieliatsyyglksvisklpdppvttrtpffnfyfg 121
                    555555555555...4557899************************66655505566666666777777777788888888888889999999999 PP

  PI3K_P85_iSH2  80 ...................................................ehEieklqenleqlksrlkelhsskekLeedlkqqkeee 118
                                                                       ++  +k  e  + l + +ke++++ e Le+d+k++k++ 
     EFC35355.1 122 edgettwlnfcrtvgaanldesykkiydsvmeidgnvlvedvealvnvhvdPQVAQKGWEEKRTLLKAIKEVEKKYETLEKDIKTNKKDF 211
                    99999999999999999999999999999999999999999999999999988888888888888899****************999875 PP

>> SKA2  Spindle and kinetochore-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1     8e-06     0.048      37      84 ..     179     224 ..     161     226 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 8e-06
        SKA2  37 a.eNpvkLlerlkkvkeelqaLkeqceellaekkelidkirttlvanre 84 
                 + e+ ++Ll+ +k+v +++++L+++   + ++kk+ ++k +t+lv+ ++
  EFC35355.1 179 GwEEKRTLLKAIKEVEKKYETLEKD---IKTNKKDFVQKRETSLVSWYN 224
                 4567799****************86...679*************99887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1332  (0.074293); expected 358.6 (0.02)
Passed bias filter:                      634  (0.0353617); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2189.15
//
Query:       EFC35356.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.039   13.7   0.1       0.11   12.3   0.1    1.7  1  Ad_cyc_g-alpha  Adenylate cyclase G-alpha binding domain


Domain annotation for each model (and alignments):
>> Ad_cyc_g-alpha  Adenylate cyclase G-alpha binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1     6e-06      0.11      16      38 ..      43      65 ..      42      68 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6e-06
  Ad_cyc_g-alpha 16 hLDTnLndMeGIlskppPltPmD 38
                    +LDTnL  +  Il  p+ l+P +
      EFC35356.1 43 KLDTNLQKVHKILENPNTLPPYS 65
                    6*******************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2066  (0.115232); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1246.00
//
Query:       EFC35357.1  [L=160]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0089   15.9   0.0      0.013   15.4   0.0    1.3  1  Phage_T4_gp19  T4-like virus tail tube protein gp19
  ------ inclusion threshold ------
       0.02   13.7   0.1      0.024   13.5   0.1    1.0  1  ATHILA         ATHILA ORF-1 family
       0.13   12.5   0.0       0.25   11.5   0.0    1.5  2  PI_PP_I        Phosphoinositide phosphatase insertion domain


Domain annotation for each model (and alignments):
>> Phage_T4_gp19  T4-like virus tail tube protein gp19
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   2.2e-06     0.013      44      89 ..       7      49 ..       2      76 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.2e-06
                   EEEEEEE--EEEEEE--HHHHHHHHHHHHT--SSB---EEEEEEEE CS
  Phage_T4_gp19 44 lpgrtkyenltLkrgltsdselvkWfkkvieggvkearknisisll 89
                   +p+  + + +t+k g+++d++l kW+++v+  + +   +++ + ++
     EFC35357.1  7 SPTVSNITLMTVKIGMMADPRLKKWYSQVNGTDAD---RKVHVAVM 49
                   6777788899*******************988776...56666665 PP

>> ATHILA  ATHILA ORF-1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1     4e-06     0.024     294     375 ..      49     134 ..      42     149 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 4e-06
      ATHILA 294 lsskglepraidldylkr.keflelkasddayrykfehselkksellLpskevTtieekenIdfkPskeil...sappedeaelte 375
                 ++s+ +++   dl yl + ++ +    + d++++ f+   +   +ll+ s e+ ++ +++ I++ P +e+l   +++p++ ++ ++
  EFC35357.1  49 MESESFLSESSDLSYLYNeMSKIRDLDVIDQFKFTFNRFMIPYERLLIQSLEIAEVLNGKVINIVPLEERLqklAKNPQKGVKRFM 134
                 46778899999****96515667777899****************************************99776555555555555 PP

>> PI_PP_I  Phosphoinositide phosphatase insertion domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       1.4   8.5e+03      64      72 ..      28      36 ..      20      50 .. 0.73
   2 ?   11.5   0.0   4.3e-05      0.25      24      88 ..      75     139 ..      54     146 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.4
                --HHHHTS- CS
     PI_PP_I 64 lPsWfnels 72
                l +W+++++
  EFC35357.1 28 LKKWYSQVN 36
                567887765 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 4.3e-05
                 -SHHHHHHHHHHHHHHHHHHHHH-SSHHHHHHHHHCT-SS--HHHHTS-HHHHHHHHHHT.T..S CS
     PI_PP_I  24 aslkklkqdlnqfllkWeeikktslsLeedLnkiannktplPsWfnelskaqqellrvlaeakls 88 
                 + + + k+ +n+f++ +e +  +sl+++e Ln    n  pl + +++l k+ q+ ++ ++  + +
  EFC35357.1  75 DVIDQFKFTFNRFMIPYERLLIQSLEIAEVLNGKVINIVPLEERLQKLAKNPQKGVKRFMRIRND 139
                 45678899*************************9999****************999998866555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       555  (0.0309554); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.43u 0.30s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1076.18
//
Query:       EFC35358.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-18   65.6   4.7    7.1e-18   65.0   4.7    1.3  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.0   4.7   3.9e-22   7.1e-18       2     118 .]      36     166 ..      35     166 .. 0.95

  Alignments for each domain:
  == domain 1  score: 65.0 bits;  conditional E-value: 3.9e-22
                 HHHHHTSHHHHHHHHHHHHHTTCT.HHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.............STT CS
         RGS   2 leslledqpgrslFreFlesefse.enlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke.............qps 86 
                 +e +++ +p r  Fr++l++   + e + F++ ve+++k++ ++++++ a +I+n+++  +s++eln++ ++r+e+ k+  +              +  
  EFC35358.1  36 IEAIFDYSPARDTFRKYLKKVCLNeEPFMFYEMVENYQKTRLDKNRLELAADIINQFIVVNSKHELNMSMAIRNEILKQHAQIleknqnlpnlellTCP 134
                 57899999************64335*****************************************************99999999**********99* PP

                 TTTTHHHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS  87 rklfeeaqeevfellekdsypkFlkselylrl 118
                 ++lf +aq+ +f+ l++d +p+F++s+ ++++
  EFC35358.1 135 SDLFANAQDVIFTELKQDNFPRFVRSKEFKKF 166
                 *****************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       756  (0.0421663); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1463.36
//
Query:       EFC35359.1  [L=229]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   14.9   0.5      0.019   14.4   0.5    1.2  1  Cluap1    Clusterin-associated protein-1


Domain annotation for each model (and alignments):
>> Cluap1  Clusterin-associated protein-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.5   1.1e-06     0.019     218     265 ..     140     187 ..     118     190 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.1e-06
      Cluap1 218 slqsvrPafmdeyekleeeLqelyeeYvekfrnlsylekqlekknkae 265
                  l+++ P +++ + + e +L+elyeeY++k+  ++ ++++ +k++k  
  EFC35359.1 140 DLEETHPDWIEAHGDPEPNLKELYEEYLQKTNPEELVKEKRDKRKKMA 187
                 68999******************************9999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1259  (0.0702214); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.37u 0.24s 00:00:00.61 Elapsed: 00:00:00.36
# Mc/sec: 1889.16
//
Query:       EFC35360.1  [L=157]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.026   14.0   0.1      0.036   13.5   0.1    1.2  1  SpoIIP    Stage II sporulation protein P (SpoIIP)
       0.19   12.0   1.9       0.52   10.6   0.2    2.0  2  IMCp      Inner membrane complex protein


Domain annotation for each model (and alignments):
>> SpoIIP  Stage II sporulation protein P (SpoIIP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   4.1e-06     0.036     175     232 ..      55     111 ..      44     119 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 4.1e-06
      SpoIIP 175 ttteinGkkvAkimfvigkknpnweknlefakklkaklekkYPglsrgillkkngrYN 232
                  tt ++ ++++ki+f +  +++nw  +l+fa + +a l + + + +++ ++    +Y 
  EFC35360.1  55 KTTYMDPETTSKIAFKMSFEEKNWAYVLRFALNTNALLTEIFEDDFKEKVI-HALKYH 111
                 4888999***********************************998888777.566665 PP

>> IMCp  Inner membrane complex protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.1     0.081   7.2e+02      59      91 ..      35      67 ..      31      69 .. 0.82
   2 ?   10.6   0.2   5.8e-05      0.52      52      84 ..     100     132 ..      96     135 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.081
        IMCp 59 vpkiekkikekivEvpqikevdrykekevveev 91
                ++ i++ i +ki++ ++ k + +y + e++ ++
  EFC35360.1 35 KSHINTSIVTKITDDIECKLKTTYMDPETTSKI 67
                567899999999999999999999988887665 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 5.8e-05
        IMCp  52 ikEriievpkiekkikekivEvpqikevdryke 84 
                  kE++i  +k++kk  e++ Ev+q   vd+++e
  EFC35360.1 100 FKEKVIHALKYHKKGFEEQKEVLQNRIVDSIQE 132
                 59***************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (157 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1006  (0.0561102); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1030.04
//
Query:       EFC35361.1  [L=108]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.038   14.8   5.2      0.042   14.6   5.2    1.1  1  PHC2_SAM_assoc  Unstructured region on Polyhomeotic-like prot


Domain annotation for each model (and alignments):
>> PHC2_SAM_assoc  Unstructured region on Polyhomeotic-like protein 1 and 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   5.2   2.4e-06     0.042      24     101 ..       5      86 ..       1      98 [. 0.72

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.4e-06
  PHC2_SAM_assoc  24 akhaRRrgkkrssselskeakkqpqqsqplsvsskllsqksqeeSsrcsDnSSyeEplsplSasssssrrrr...ge.rele 101
                     +k ++R+++  ss  + k+ kk++++ q++  s++ +s++    Ss  sD S      spl  s++ ++r +   +e r  e
      EFC35361.1   5 KKDKKRKTPETSSDITPKKDKKKTKKEQTIIASTPSTSSQPATPSSSKSDTSLPFSTDSPLTFSPPVPPRPKivaSErRAXE 86 
                     44566777777777666777888888888888888888888899********999999*******99966654332323333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1207  (0.0673211); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 708.31
//
Query:       EFC35362.1  [L=365]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0095   15.7   0.8      0.018   14.8   0.8    1.4  1  DUF4364          Domain of unknown function (DUF4364)
  ------ inclusion threshold ------
      0.045   13.9   0.0       0.11   12.6   0.0    1.6  1  Cdc13_OB4_dimer  Cdc13 OB4 dimerization domain
      0.076   13.5   1.2       0.19   12.3   0.2    2.2  2  NTS              N-terminal segments of PfEMP1
        0.1   11.9   0.2       0.17   11.2   0.2    1.2  1  7TM_GPCR_Srz     Serpentine type 7TM GPCR chemoreceptor Srz
        1.8    9.2   5.1        2.2    8.9   2.7    2.2  2  PAS_10           PAS domain


Domain annotation for each model (and alignments):
>> DUF4364  Domain of unknown function (DUF4364)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.8   5.1e-06     0.018      33     109 ..      65     142 ..      63     159 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.1e-06
     DUF4364  33 YfdlqqalseLvesglieee.ekenktlykiTekGketlelfenripksirekideylkenkeelkkesevkadyykk 109
                 Y++ +++l+ L+++++i +  +   k++y+   +G+++ +++   +  ++  ki + + e++ ++ + + +k+   +k
  EFC35362.1  65 YVEDEEMLNSLMNKKHIVKLtKAGRKNVYRKLTQGRRNSKMLRRLVKRQVARKISHRMTEKRGRIGQSVHNKVSNNNK 142
                 7777899**********9995669999*************************************99999888765544 PP

>> Cdc13_OB4_dimer  Cdc13 OB4 dimerization domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   3.1e-05      0.11      30      86 ..      63     119 ..      54     130 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.1e-05
                      EEEEESS---T--B-GGG-EEEEEESHHHHHHHHSSS---GGGCGGGBTSEEEEEEE CS
  Cdc13_OB4_dimer  30 elyvtndlilkkkvdpkeiLkveilGkenvnyFlgdeealedilraLvlktlkfrll 86 
                       lyv ++ +l+  ++ k+i+k+   G++nv   l++++   ++lr Lv++++  ++ 
       EFC35362.1  63 SLYVEDEEMLNSLMNKKHIVKLTKAGRKNVYRKLTQGRRNSKMLRRLVKRQVARKIS 119
                      699****************************99999**************9987765 PP

>> NTS  N-terminal segments of PfEMP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.2   5.2e-05      0.19       8      22 ..     128     144 ..     128     150 .. 0.82
   2 ?   -3.1   0.0       3.2   1.2e+04       9      13 ..     243     247 ..     243     260 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.2e-05
         NTS   8 sIGkkVhdkvkkea..a 22 
                 +IG++Vh+kv ++   a
  EFC35362.1 128 RIGQSVHNKVSNNNkhA 144
                 7***********95444 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.2
         NTS   9 IGkkV 13 
                 IGkkV
  EFC35362.1 243 IGKKV 247
                 89998 PP

>> 7TM_GPCR_Srz  Serpentine type 7TM GPCR chemoreceptor Srz
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.2   4.6e-05      0.17      39      64 ..      17      42 ..      10      47 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4.6e-05
  7TM_GPCR_Srz 39 ivnhFykmvkityilfvilivllili 64
                  +v+hF kmvk+ y++f +li+l+i++
    EFC35362.1 17 LVKHFKKMVKLNYLIFAVLICLAIVV 42
                  69*****************9998876 PP

>> PAS_10  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   2.7   0.00062       2.2      10      79 ..      82     153 ..      72     165 .. 0.80
   2 ?   -0.4   0.0      0.49   1.8e+03      46      76 ..     164     196 ..     157     205 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00062
      PAS_10  10 ieltflDdnlqirrFtp...aakklfklipadvGrpladihpkkavknveeviealrtgekdevevvvpkngk 79 
                 ++lt + +++  r+ t+   ++k+l +l++ +v r++++  ++k+    ++v +++++++k+ +++v +kn +
  EFC35362.1  82 VKLTKAGRKNVYRKLTQgrrNSKMLRRLVKRQVARKISHRMTEKRGRIGQSVHNKVSNNNKHAKRTVSNKN-R 153
                 56777777888888888666789**************************************9999776644.3 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.49
      PAS_10  46 ihpk..kavknveeviealrtgekdevevvvpk 76 
                 +h++  ++ +n+++++ +++ +e++  ++++++
  EFC35362.1 164 FHSEgvSSPSNTNKIVSDVKPRETKDIRKPIEN 196
                 566666778899999999999999998888764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (365 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1454  (0.0810977); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.44
# Mc/sec: 2473.69
//
Query:       EFC35363.1  [L=145]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (145 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       604  (0.0336884); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 933.67
//
Query:       EFC35364.1  [L=107]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (107 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       839  (0.0467957); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 689.73
//
Query:       EFC35365.1  [L=250]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.081   12.7   0.1       0.21   11.3   0.1    1.6  1  KRE1         Killer toxin-resistance protein 1
       0.85    9.6   4.0        1.7    8.6   4.0    1.4  1  Macscav_rec  Macrophage scavenger receptor


Domain annotation for each model (and alignments):
>> KRE1  Killer toxin-resistance protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   2.4e-05      0.21      12      45 ..      68     102 ..      61     102 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.4e-05
        KRE1  12 TvtsnGklttvqttYsQsFsstyteva.svssGsI 45 
                  vt+n++++ vq+ ++Q+F++t  + + s  sG++
  EFC35365.1  68 PVTVNDNFQNVQVFFEQRFNNTAFDFTlSLLSGKV 102
                 5899******************9998877888876 PP

>> Macscav_rec  Macrophage scavenger receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   4.0   0.00019       1.7      19      36 ..      73      90 ..      70      99 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00019
  Macscav_rec 19 ehFqNfSvttdQrfndvL 36
                 ++FqN+ v  +Qrfn+  
   EFC35365.1 73 DNFQNVQVFFEQRFNNTA 90
                 79*************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       525  (0.0292822); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1673.55
//
Query:       EFC35366.1  [L=244]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0012   17.6   1.2     0.0017   17.1   1.2    1.1  1  DUF4455          Domain of unknown function (DUF4455)
     0.0025   16.8   0.7     0.0033   16.5   0.7    1.1  1  IFT57            Intra-flagellar transport protein 57
     0.0042   17.5   1.0      0.027   14.9   0.2    2.1  2  Snapin_Pallidin  Snapin/Pallidin
  ------ inclusion threshold ------
      0.021   15.0   0.4        0.4   10.9   0.2    2.4  2  SesA             N-terminal domain on NACHT_NTPase and P-loop
      0.025   13.3   0.4      0.085   11.6   0.2    1.6  2  DUF2207          Predicted membrane protein (DUF2207)
      0.033   14.3   0.0      0.078   13.1   0.0    1.6  1  DUF4337          Domain of unknown function (DUF4337)
      0.043   14.4   2.7      0.066   13.7   2.7    1.3  1  APG6_N           Apg6 coiled-coil region
      0.045   13.2   0.4       0.18   11.2   0.1    1.9  2  HBM              Helical bimodular sensor domain
      0.056   13.2   1.2       0.13   12.1   1.2    1.5  1  FAM184           Family with sequence similarity 184, A and B
       0.06   13.6   0.4       0.15   12.3   0.1    1.7  1  DUF5082          Domain of unknown function (DUF5082)
       0.06   13.6   2.3       0.63   10.4   0.5    2.2  2  KxDL             Uncharacterized conserved protein
      0.096   12.2   2.7       0.24   10.9   1.2    2.3  3  DUF4225          Protein of unknown function (DUF4225)
       0.11   11.7   1.1        0.2   10.9   0.3    1.6  2  TMPIT            TMPIT-like protein
       0.13   12.3   1.2        1.7    8.7   0.2    2.4  2  DUF1664          Protein of unknown function (DUF1664)
       0.16   12.4   1.6         15    6.0   0.1    3.1  2  FlaC_arch        Flagella accessory protein C (FlaC)
        0.2   12.0   1.0       0.41   11.0   0.2    1.9  2  PRD              PRD domain
       0.24   11.5   3.1        0.5   10.5   3.1    1.4  1  Mod_r            Modifier of rudimentary (Mod(r)) protein
       0.25   10.6   1.8        1.1    8.5   2.3    1.6  2  MIS13            Mis12-Mtw1 protein family
          1   10.1   4.9        7.6    7.3   1.7    2.2  2  Occludin_ELL     Occludin homology domain


Domain annotation for each model (and alignments):
>> DUF4455  Domain of unknown function (DUF4455)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   1.2   1.8e-06    0.0017     307     431 ..      23     147 ..       8     153 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 1.8e-06
     DUF4455 307 eellplvgklqrkaeeelekldksleelaketeaqsesLfkffqeaaqlwevheaklekqeeelekkleqlrqkhdeenqakeaeLdklldklrqa.st 404
                 e ++p++++  ++++e+l+++dk +++l ket+a   ++ + + ++    e  +a l+ + ++l   +e + q    + q++e++ d+ ++kl  + ++
  EFC35366.1  23 ENCFPIINNGMQSVQEYLNEMDKHVSKLGKETRADYLQFKRDVVSMTTECEDVCASLKGIFDSLLSMIERYEQGI-FDAQDCENAIDSQMKKLSDEfAK 120
                 78********************************99999888888888888888899999999999999887755.67899************998456 PP

     DUF4455 405 eekLketlekalqlLddikkeYeefhk 431
                  e++k++ ++  q+ ++i +e+ +++k
  EFC35366.1 121 LENVKKLIDESTQKCSNISQEFYKYRK 147
                 699**************9999887766 PP

>> IFT57  Intra-flagellar transport protein 57
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.7   3.5e-06    0.0033     197     307 ..      36     142 ..      28     154 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3.5e-06
       IFT57 197 aaeWklEleRvlpqLkvtikadakdWrahleqmkkhkksieeslpetksqlkklhedisktlekiesrEkylnsqleellqeyreaqeelsevkekykq 295
                  +e+  E+ +  ++L ++++ad  ++++++ +m +  + + +sl+ +  +l  + e  ++ +   +  E+ ++sq+++l +e+ ++++  + + e    
  EFC35366.1  36 VQEYLNEMDKHVSKLGKETRADYLQFKRDVVSMTTECEDVCASLKGIFDSLLSMIERYEQGIFDAQDCENAIDSQMKKLSDEFAKLENVKKLIDE---- 130
                 5788899999999********************************************************************99876554444443.... PP

       IFT57 296 lsegvseltrel 307
                  +++ s+ ++e+
  EFC35366.1 131 STQKCSNISQEF 142
                 333333333333 PP

>> Snapin_Pallidin  Snapin/Pallidin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.67   6.3e+02      70      89 ..      31      50 ..      28      52 .. 0.68
   2 !   14.9   0.2   2.9e-05     0.027       5      71 ..      80     141 ..      79     152 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.67
  Snapin_Pallidin 70 krmsslnerlqklkkRaekL 89
                     + m+s++e l+++ k ++kL
       EFC35366.1 31 NGMQSVQEYLNEMDKHVSKL 50
                     56777777777777777665 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 2.9e-05
  Snapin_Pallidin   5 egllellepkldeldeklkelrqsQeeLleqldrlnekLkeleeaqeaevlpdlkeyakKLvnikkr 71 
                      +g+++ l +++++ ++ + + +++ ++  +q+++l++++++le++++      ++e  +K +ni ++
       EFC35366.1  80 KGIFDSLLSMIERYEQGIFDAQDCENAIDSQMKKLSDEFAKLENVKK-----LIDESTQKCSNISQE 141
                      599999**************************************999.....778888888887765 PP

>> SesA  N-terminal domain on NACHT_NTPase and P-loop NTPases
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.2   0.00042       0.4      28      84 ..      26      90 ..      20     137 .. 0.78
   2 ?    2.6   0.4      0.16   1.5e+02      55     101 ..     100     148 ..      85     160 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00042
        SesA 28 FrevgkrLplvqetLedaksqlesskldedtesa.....ikpvlesckekatkleeifekv...a 84
                F  +++  + vqe L++  +++++  +++ ++       + ++ ++c++  ++l+ if+ +    
  EFC35366.1 26 FPIINNGMQSVQEYLNEMDKHVSKLGKETRADYLqfkrdVVSMTTECEDVCASLKGIFDSLlsmI 90
                667899999999999999999999988888777699999********************985541 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.16
        SesA  55 dedtesaikpvlesckekatkleeifekvapapad.srl.eryrkavrs 101
                  +d e+ai +  ++ +++ +kle++ + + +++++ s++ ++++k+ ++
  EFC35366.1 100 AQDCENAIDSQMKKLSDEFAKLENVKKLIDESTQKcSNIsQEFYKYRKE 148
                 4455555666666666666666666666655555555555555555444 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.54   5.1e+02     327     366 ..      26      67 ..      18      85 .. 0.62
   2 ?   11.6   0.2     9e-05     0.085     327     409 ..      98     207 ..      78     240 .. 0.46

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.54
     DUF2207 327 fdkseeg.ks....lkeikkyakkskkkakkfkkalkkwksavkk 366
                 f  +++g +s    l+e+ k+++k   ++k+ ++ + ++k++v +
  EFC35366.1  26 FPIINNGmQSvqeyLNEMDKHVSK---LGKETRADYLQFKRDVVS 67 
                 455555555566677788888877...777777777777777766 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 9e-05
     DUF2207 327 fdkseegks......lkeikkyakkskkkakkfkkalkkwksavkk......kergyfdkkgkkklkklsalglgliilglilillallllvll..... 408
                 f      +       +++  k+++++ +k +++kk +++ ++++ +      k+r+ fdk+        ++  l++  +gli +++++++ v++     
  EFC35366.1  98 F------DAqdcenaIDSQMKKLSDEFAKLENVKKLIDESTQKCSNisqefyKYRKEFDKA--------NVCKLLGSAVGLISSMALVGAGVSVvslgl 182
                 3......223332222222222222222555555555555555555443344444444444........444444444444443333333333222244 PP

     DUF2207 409 ........................l 409
                                          
  EFC35366.1 183 yiafnpgvnipivsqafgaltvqhG 207
                 5555555666666666666666551 PP

>> DUF4337  Domain of unknown function (DUF4337)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   8.2e-05     0.078      67     157 ..      97     185 ..      78     188 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 8.2e-05
     DUF4337  67 k..aeelaaavdkkiakykkkiarykkekkeikkkAkeleaerdeaneasdkfdlasalLqiaIvlaaialltkkklllylslvlglvGlvlf 157
                    a++ ++a+d++ +k++++ a+ ++ kk i +  ++  + ++e  +  ++fd a     ++ +l++   l+++ +l+ +++ +  +Gl+++
  EFC35366.1  97 IfdAQDCENAIDSQMKKLSDEFAKLENVKKLIDESTQKCSNISQEFYKYRKEFDKAN----VCKLLGSAVGLISSMALVGAGVSVVSLGLYIA 185
                 255788999***********************************************6....78899999999999999999999999999876 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   2.7     7e-05     0.066      11      96 ..      40     123 ..      36     153 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 7e-05
      APG6_N  11 leeldkqleqaeke.rdaYeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealee 96 
                 l+e+dk+++++ ke r +Y++f + + + ++e e   + +++l+  ++ l +  e+ ++ + ++++ + ++++++++l+ e ++le+
  EFC35366.1  40 LNEMDKHVSKLGKEtRADYLQFKRDVVSMTTECE---DVCASLKGIFDSLLSMIERYEQGIFDAQDCENAIDSQMKKLSDEFAKLEN 123
                 899*****9998874789**********977755...78888888899999999999999999999999999999999999998886 PP

>> HBM  Helical bimodular sensor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.63   5.9e+02     170     197 ..      34      61 ..      29      67 .. 0.61
   2 ?   11.2   0.1    0.0002      0.18      52      99 ..     106     154 ..      89     160 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.63
                 HHHHHHHHHHHHHHHH-GG.GHHHHHHH CS
         HBM 170 taldaalaeldqlrqalasdpraalqql 197
                 + +++ l+e+d++ ++l ++ ra++ q+
  EFC35366.1  34 QSVQEYLNEMDKHVSKLGKETRADYLQF 61 
                 5556666666666666666666666555 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.0002
                 HHHHHHHHHHHH--SHHHHHH.HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         HBM  52 elkaqlqklkakfkspenvrl.Lqeqlalvqeyrksfnelraayesrna 99 
                  +++q++kl ++f + env++ ++e +++ +++ ++f + r+ ++++n 
  EFC35366.1 106 AIDSQMKKLSDEFAKLENVKKlIDESTQKCSNISQEFYKYRKEFDKANV 154
                 57899**************862699*******************99885 PP

>> FAM184  Family with sequence similarity 184, A and B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.2   0.00013      0.13      70     160 ..      37     133 ..      11     157 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00013
      FAM184  70 rqalaefeqykrrveerelkleaehsqkvvelsreveevkrkFeeklrqfaqlqeqle......qekekaLeelrkkhreeveeLlkeqeaqsekll 160
                 +++l+e++++  +  +++ ++  +++  vv++ +e e+v +  +    ++ ++ e+ e      q+ e+a+++  kk ++e  +L++ ++   e+ +
  EFC35366.1  37 QEYLNEMDKHVSKLGKETRADYLQFKRDVVSMTTECEDVCASLKGIFDSLLSMIERYEqgifdaQDCENAIDSQMKKLSDEFAKLENVKKLIDESTQ 133
                 788999999999999999999999999999999999999999999999999999998899999*************99**99999987776555443 PP

>> DUF5082  Domain of unknown function (DUF5082)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   0.00016      0.15      44     121 ..      34     114 ..      29     117 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00016
     DUF5082  44 kqkkkklekplnssesWkGkeennydgirs...nlessyqtyvdkldelidaieeEIerLenqiseaqgvldtlqsqlnsl 121
                 ++ +++l++++ + + + ++++++y ++ +   ++ ++++ +   l+ + d++ + Ier+e+ i +aq   + ++sq+++l
  EFC35366.1  34 QSVQEYLNEMDKHVSKLGKETRADYLQFKRdvvSMTTECEDVCASLKGIFDSLLSMIERYEQGIFDAQDCENAIDSQMKKL 114
                 45566777777777788888********999999999*************************9988877766666666665 PP

>> KxDL  Uncharacterized conserved protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.1      0.14   1.3e+02      60      82 ..      36      58 ..      28      95 .. 0.56
   2 ?   10.4   0.5   0.00066      0.63       4      55 ..      96     147 ..      93     153 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.14
        KxDL 60 vkkdLesifkkirslkaklakky 82
                v++ L+ + k++++l ++++++y
  EFC35366.1 36 VQEYLNEMDKHVSKLGKETRADY 58
                44444444444444444444433 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00066
        KxDL   4 savdsedldeilalQaqtsgrlnkknreLlelnalsqerlaklrarfkqgtk 55 
                 +++d +d +++++ Q + +    +k + +++l+++s ++ ++++++f ++ k
  EFC35366.1  96 GIFDAQDCENAIDSQMKKLSDEFAKLENVKKLIDESTQKCSNISQEFYKYRK 147
                 689************9988888899**********************88765 PP

>> DUF4225  Protein of unknown function (DUF4225)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0         1   9.8e+02      78     137 ..      30      84 ..      24      91 .. 0.52
   2 ?   10.9   1.2   0.00026      0.24       2      85 ..     113     212 ..     112     224 .. 0.75
   3 ?    0.4   0.5      0.44   4.1e+02      41      57 ..     205     222 ..     194     237 .. 0.49

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1
     DUF4225  78 lhGannvvenisyllgreektGlvrdvYreaaeklGyskkdgdllYaavDlslSlyglfk 137
                  +G+ +v e ++++ ++ +k      + +  a+ l ++++   ++ +  D+ +Sl+g+f 
  EFC35366.1  30 NNGMQSVQEYLNEMDKHVSKL-----GKETRADYLQFKRDVVSMTTECEDVCASLKGIFD 84 
                 444444444444333332222.....2334444455555555666666677777777765 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00026
     DUF4225   2 elkkEieslrkqdemLrlkkakkyvvvei.......keenkvikyvikgigvVagglqivaGvalv.........skasetvvgavaGalLilhGannv 84 
                 +l +E ++l++ ++ +   + k + + +        +++ +v+k+  +++g++++++ + aGv +v               +v++ +Gal + hG++ v
  EFC35366.1 113 KLSDEFAKLENVKKLIDESTQKCSNISQEfykyrkeFDKANVCKLLGSAVGLISSMALVGAGVSVVslglyiafnPGVNIPIVSQAFGALTVQHGIGMV 211
                 6888888888888777766665554444368888889999**************************877643321122334678899999999998766 PP

     DUF4225  85 v 85 
                 +
  EFC35366.1 212 S 212
                 5 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.44
     DUF4225  41 ikgigvVaggl.qivaGv 57 
                  +gig+V++g+ ++va +
  EFC35366.1 205 QHGIGMVSAGTtAVVASA 222
                 334444443321333333 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.28   2.7e+02       4      56 ..      40      93 ..      19     100 .. 0.60
   2 ?   10.9   0.3   0.00021       0.2       6     103 ..      74     172 ..      69     181 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.28
       TMPIT  4 weelekefkel.eetakeykqkleelsklqskcskeikkqkkrlkelksslkkl 56
                ++e+ k++ +l +et   y q  +++ ++ ++c    ++ k    +l s+++++
  EFC35366.1 40 LNEMDKHVSKLgKETRADYLQFKRDVVSMTTECEDVCASLKGIFDSLLSMIERY 93
                344445555542334455666666666666666666666666666666665555 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00021
       TMPIT   6 elekefkeleetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelkerkkvlk..evesllpkknglylklvlG 102
                 ++  ++k + ++  +++++ e+     ++c ++i++q k+l++  ++l+++kk + +e+ ++++++++e+ + +k ++  +v +ll +  gl  ++ l 
  EFC35366.1  74 DVCASLKGIFDSLLSMIERYEQGIFDAQDCENAIDSQMKKLSDEFAKLENVKKLI-DESTQKCSNISQEFYKYRKEFDkaNVCKLLGSAVGLISSMALV 171
                 55555566666666677777888888899**********************9987.5888999999999999999998566677777777777776665 PP

       TMPIT 103 n 103
                  
  EFC35366.1 172 G 172
                 4 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.25   2.3e+02      99     121 ..      29      51 ..      12      54 .. 0.74
   2 ?    8.7   0.2    0.0018       1.7      43     108 ..      65     130 ..      59     142 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.25
     DUF1664  99 igedvesvkeaveglesklerie 121
                 i++ ++sv+e  ++++++++++ 
  EFC35366.1  29 INNGMQSVQEYLNEMDKHVSKLG 51 
                 66677778888888877777764 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0018
     DUF1664  43 vesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvke 108
                 v s++++ e+v +sl+   + L s i+r ++ + + +++ ++i++++++++++ +++++  + ++e
  EFC35366.1  65 VVSMTTECEDVCASLKGIFDSLLSMIERYEQGIFDAQDCENAIDSQMKKLSDEFAKLENVKKLIDE 130
                 668999999999999999999**********99999999999999999999998887655444444 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.1     0.016        15       3      35 ..      20      52 ..      19      95 .. 0.88
   2 ?    4.0   0.3     0.068        65       5      33 ..     107     138 ..     104     151 .. 0.60

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.016
   FlaC_arch  3 delEnklsklsteletvkkeneelsksveelke 35
                d +En ++ +   +++v++ ++e+ k v +l +
  EFC35366.1 20 DCVENCFPIINNGMQSVQEYLNEMDKHVSKLGK 52
                6789999999999999******99999999865 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.068
   FlaC_arch   5 lEnklsklst...eletvkkeneelsksveel 33 
                 ++++++kls    +le+vkk ++e  ++  ++
  EFC35366.1 107 IDSQMKKLSDefaKLENVKKLIDESTQKCSNI 138
                 45555555554445555555555555555555 PP

>> PRD  PRD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       3.6   3.4e+03      45      68 ..      18      41 ..       9      50 .. 0.46
   2 ?   11.0   0.2   0.00043      0.41      22      72 ..      80     133 ..      77     151 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 3.6
                HHHHHHHHTHHHHHHHHHHHHHHH CS
         PRD 45 lleeikekypkefeiakeileele 68
                 ++ +++++p + + ++++ e+l+
  EFC35366.1 18 IMDCVENCFPIINNGMQSVQEYLN 41
                444444443333333333333333 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00043
                 HHHHHHHHHHHHHHHTT....--HHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHT CS
         PRD  22 erLitHlkfaieRlkeg....itienplleeikekypkefeiakeileeleeeld 72 
                 +++++ l ++ieR ++g    ++ en   +++k+  ++ef+  +++ + ++e+++
  EFC35366.1  80 KGIFDSLLSMIERYEQGifdaQDCENAIDSQMKKL-SDEFAKLENVKKLIDESTQ 133
                 67888999*************************95.*********9999999876 PP

>> Mod_r  Modifier of rudimentary (Mod(r)) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   3.1   0.00053       0.5      17     126 ..      35     150 ..      28     152 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00053
       Mod_r  17 klealvktlpevkqlkeekeellaeneslaeknlslepeleelrselqekleelkelekefee.......keqeldellqkfspd.allarLqtavaea 107
                  ++++++++++   + +  +e +a   ++ ++  s  +e e++ ++l+  +++l ++ +++e+        e+  d+ ++k+s++ a l+++++ ++e+
  EFC35366.1  35 SVQEYLNEMDK--HVSKLGKETRADYLQFKRDVVSMTTECEDVCASLKGIFDSLLSMIERYEQgifdaqdCENAIDSQMKKLSDEfAKLENVKKLIDES 131
                 55666666633..555555666677788888888889999999999999999988888888762221111344445555999999445789******** PP

       Mod_r 108 eeeSealaeeflegeield 126
                  +++ ++++ef++  +e+d
  EFC35366.1 132 TQKCSNISQEFYKYRKEFD 150
                 ***********97666655 PP

>> MIS13  Mis12-Mtw1 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.35   3.3e+02     217     265 ..      13      62 ..       3      90 .. 0.68
   2 ?    8.5   2.3    0.0012       1.1     220     277 ..      71     149 ..      34     159 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.35
                 -S--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHH.C CS
       MIS13 217 pdtaqrilsdnanveskletkvDeLqdsvhkLdsaskalnelst.qklq.k 265
                  dt  +i++ ++n +  +++ +  +q+  + +d++++ l ++++ ++lq k
  EFC35366.1  13 IDTN-PIMDCVENCFPIINNGMQSVQEYLNEMDKHVSKLGKETRaDYLQfK 62 
                 4555.6667777777777888888888888888877666555441555544 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0012
                 -......................HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTSTTTSSXXXXX CS
       MIS13 220 a......................qrilsdnanveskletkvDeLqdsvhkLdsaskalnelstqklqklsrllakrskke 277
                                        ++   d ++ e+ ++ ++++L+d+  kL+  +k l ++stqk   +s + +k++k+ 
  EFC35366.1  71 EcedvcaslkgifdsllsmieryEQGIFDAQDCENAIDSQMKKLSDEFAKLEN-VKKLIDESTQKCSNISQEFYKYRKEF 149
                 455555555555555555664444445578999999****************9.78888999999999999999998875 PP

>> Occludin_ELL  Occludin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.1     0.089        84      30      68 ..      32      71 ..      22      95 .. 0.62
   2 ?    7.3   1.7    0.0081       7.6      26      68 ..     106     147 ..      87     157 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.089
  Occludin_ELL 30 eleevskkfseLerelkelkegsk.eykkieeeilqeykk 68
                   +++v++ ++e+++++++l ++++  y + ++++++   +
    EFC35366.1 32 GMQSVQEYLNEMDKHVSKLGKETRaDYLQFKRDVVSMTTE 71
                  5566666666666666666665555555555555544443 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0081
  Occludin_ELL  26 elhaeleevskkfseLerelkelkegskeykkieeeilqeykk 68 
                   ++ ++++++s++f++Le+  k  +e++++ ++i +e + +y+k
    EFC35366.1 106 AIDSQMKKLSDEFAKLENVKKLIDESTQKCSNISQE-FYKYRK 147
                   567889999999999999999999999999999999.445544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1706  (0.0951531); expected 358.6 (0.02)
Passed bias filter:                     1042  (0.0581181); expected 358.6 (0.02)
Passed Vit filter:                       129  (0.00719505); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 1449.83
//
Query:       EFC35367.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-05   26.0   0.2     0.0002   21.9   0.0    2.6  3  Sel1      Sel1 repeat
  ------ inclusion threshold ------
       0.23   11.3  22.2        1.1    9.2  14.3    2.5  2  ZZ        Zinc finger, ZZ type


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.0   2.2e-08    0.0002      13      38 .]       2      27 ..       1      27 [. 0.92
   2 ?    0.8   0.0       0.1   9.1e+02       8      30 ..      35      56 ..      35      60 .. 0.81
   3 ?   -1.2   0.0      0.43   3.9e+03      12      17 ..     104     109 ..      97     128 .. 0.69

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 2.2e-08
        Sel1 13 ylnGlgvpkDpekAiewyekAAeqGd 38
                +  G gv++D+++A+ w++ A++qGd
  EFC35367.1  2 FSSGEGVEQDIDRAMFWLKEACDQGD 27
                56799********************7 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.1
        Sel1  8 GmfylylnGl.gvpkDpekAiewy 30
                G   ++++Gl + + D ek ++++
  EFC35367.1 35 G--IMHYFGLhDCELDLEKSRQFL 56
                5..6899***88999999988876 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.43
        Sel1  12 lylnGl 17 
                 +y+nG 
  EFC35367.1 104 CYENGA 109
                 456664 PP

>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2  14.3   0.00012       1.1       6      36 ..      76     106 ..      72     109 .. 0.87
   2 ?    7.3   0.9   0.00044       3.9       3      16 ..     107     120 ..     106     125 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00012
                 E-TTT-S..EESSEEEESSSS.S-EE-HHHHH CS
          ZZ   6 tCdgCseapligvRyhclrcs.dYDLCqsCfs 36 
                  C++C   +  g+ y c+  s d+DLCq+C+ 
  EFC35367.1  76 CCNECFV-EDFGFNYECANLScDFDLCQRCYE 106
                 5****99.999******98655********97 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.00044
                 S-EE-TTT-S..EE CS
          ZZ   3 kkytCdgCseapli 16 
                 ++++C++C++  ++
  EFC35367.1 107 NGAKCNKCGNSKFA 120
                 6799*****97665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       861  (0.0480228); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 987.69
//
Query:       EFC35368.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.5e-17   59.7  13.2      0.027   14.5   0.0    7.1  7  LRR_6     Leucine Rich repeat
    1.5e-14   53.5  14.9    1.5e-06   27.8   1.7    4.1  4  LRR_8     Leucine rich repeat
    5.8e-13   48.8  22.2     0.0007   19.9   2.5    5.1  5  LRR_4     Leucine Rich repeats (2 copies)
    6.7e-08   32.0  11.9        3.1    8.7   0.0    6.8  7  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1     0.086   3.9e+02       4      13 ..       2      11 ..       1      12 [. 0.83
   2 !   14.2   0.0   7.4e-06     0.033       4      23 ..      26      45 ..      23      46 .. 0.90
   3 !   14.5   0.0   6.1e-06     0.027       4      23 ..      50      69 ..      47      70 .. 0.90
   4 !    8.7   0.0   0.00045         2       5      24 .]      75      95 ..      72      95 .. 0.93
   5 !    5.1   0.2    0.0061        28       3      13 ..      98     108 ..      96     111 .. 0.89
   6 !   14.1   0.4   8.3e-06     0.037       3      17 ..     122     136 ..     120     137 .. 0.89
   7 !    4.6   0.0    0.0087        39       3      18 ..     144     159 ..     142     159 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.086
       LRR_6  4 hLteLdLsgN 13
                +Lt LdL +N
  EFC35368.1  2 KLTCLDLYSN 11
                8*****9777 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 7.4e-06
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                +L++L+++++d++D+ ++ +
  EFC35368.1 26 NLKYLNVRYCDMDDKSVKYI 45
                8**************99876 PP

  == domain 3  score: 14.5 bits;  conditional E-value: 6.1e-06
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                +Lt+L+++ N I+D+G++ +
  EFC35368.1 50 NLTHLNVNENYISDKGVKFI 69
                8****************987 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.00045
       LRR_6  5 LteLdLsgNd.IgDeGaeaLa 24
                L eL++ +N  I+ +G+e ++
  EFC35368.1 75 LVELEIEDNPtISPQGVELIC 95
                889***************998 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.0061
       LRR_6   3 thLteLdLsgN 13 
                 t Lt+L++ +N
  EFC35368.1  98 TQLTHLNIGCN 108
                 67********9 PP

  == domain 6  score: 14.1 bits;  conditional E-value: 8.3e-06
       LRR_6   3 thLteLdLsgNdIgD 17 
                  +Lt+LdL+gN+Ig+
  EFC35368.1 122 KNLTSLDLNGNEIGN 136
                 68************8 PP

  == domain 7  score: 4.6 bits;  conditional E-value: 0.0087
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 ++Lt+L++ + ++++e
  EFC35368.1 144 SKLTYLNIGYSCMNNE 159
                 79******99988776 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.1   5.3e-05      0.24      26      60 ..       2      36 ..       1      37 [. 0.85
   2 !   17.5   0.1   5.6e-07    0.0025      22      59 ..      46      83 ..      41      84 .. 0.92
   3 !   27.8   1.7   3.4e-10   1.5e-06      23      61 .]      96     134 ..      91     134 .. 0.96
   4 !    4.8   0.2    0.0052        24      22      38 ..     141     157 ..     136     160 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 5.3e-05
                T--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8 26 nLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60
                +L+ LdL +N+ t  +   +s L++L++L++++++
  EFC35368.1  2 KLTCLDLYSNTTTEQDLIHISRLKNLKYLNVRYCD 36
                57889999999999999999999999999998876 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 5.6e-07
                TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8 22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59
                 +l+nL++L+ ++N ++    + +s L++L +L +++N
  EFC35368.1 46 GKLENLTHLNVNENYISDKGVKFISELKQLVELEIEDN 83
                579*********************************99 PP

  == domain 3  score: 27.8 bits;  conditional E-value: 3.4e-10
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 g+++L++L++++N l++ + + +  L++L+sLdL+gN +
  EFC35368.1  96 GMTQLTHLNIGCNYLNFENTRELTKLKNLTSLDLNGNEI 134
                 799**********************************87 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.0052
                 TT-TT--EEE--SS--- CS
       LRR_8  22 kglsnLkvLdLsnNllt 38 
                 + ls+L++L++++ +++
  EFC35368.1 141 SELSKLTYLNIGYSCMN 157
                 66999999999998875 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.8   4.4e-06      0.02       2      32 ..       2      34 ..       2      40 .. 0.83
   2 !   11.6   0.2   6.8e-05       0.3      17      38 ..      43      63 ..      39      64 .. 0.80
   3 !   13.3   0.7     2e-05     0.089       2      36 ..      50      86 ..      49      89 .. 0.84
   4 !   10.5   0.4   0.00015      0.66      20      39 ..      95     112 ..      86     123 .. 0.74
   5 !   19.9   2.5   1.6e-07    0.0007       1      32 [.     122     152 ..     122     162 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 4.4e-06
                S--EEE--SS---E-S-..HHH.-TT--EEE-.- CS
       LRR_4  2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsg 32
                +L+ LdL +N  t+ +l  + + l+nLk+L++  
  EFC35368.1  2 KLTCLDLYSNTTTEQDLihI-SrLKNLKYLNVRY 34
                79***************642.55********844 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 6.8e-05
                S-HHH-TT--EEE-.-S----- CS
       LRR_4 17 plleklpnLkeLdLsgNnlitd 38
                  ++kl nL++L++++N +i+d
  EFC35368.1 43 KYIGKLENLTHLNVNEN-YISD 63
                45678*********888.8865 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 2e-05
                S--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4  2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36
                nL++L+ + N ++d +  + + l++L eL + +N+ i
  EFC35368.1 50 NLTHLNVNENYISDKGVkFISeLKQLVELEIEDNPTI 86
                9*******99***866686655*********999666 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 0.00015
                 HH-TT--EEE-.-S-----G CS
       LRR_4  20 eklpnLkeLdLsgNnlitdl 39 
                  ++++L++L++ g+n++ ++
  EFC35368.1  95 CGMTQLTHLNI-GCNYL-NF 112
                 36*********.99999.44 PP

  == domain 5  score: 19.9 bits;  conditional E-value: 1.6e-07
                 SS--EEE--SS---E-S-HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsg 32 
                 +nL++LdL++N +     l+ l +L++L++ g
  EFC35368.1 122 KNLTSLDLNGNEIGNATYLSELSKLTYLNI-G 152
                 79*************999999********9.2 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1      0.39   1.8e+03       1      10 [.       2      11 ..       2      21 .. 0.86
   2 !    8.7   0.0    0.0007       3.1       1      22 [.      26      47 ..      26      48 .. 0.84
   3 !    7.3   0.1     0.002       8.9       1      21 [.      50      70 ..      50      72 .. 0.83
   4 ?    1.1   0.0      0.21   9.5e+02       2      11 ..      75      84 ..      74      93 .. 0.79
   5 !    5.5   0.2    0.0078        35       1      12 [.      99     110 ..      99     120 .. 0.83
   6 !    7.6   0.2    0.0016       7.2       1      12 [.     123     134 ..     123     143 .. 0.87
   7 ?    2.7   0.0     0.063   2.8e+02       1      11 [.     145     155 ..     145     168 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.39
       LRR_1  1 nLrhLdLsnn 10
                +L+ LdL +n
  EFC35368.1  2 KLTCLDLYSN 11
                7999***887 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0007
       LRR_1  1 nLrhLdLsnnpllglppnsfqn 22
                nL++L+++++  ++++  ++ +
  EFC35368.1 26 NLKYLNVRYCDMDDKSVKYIGK 47
                8*********998888777766 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.002
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                nL+hL+++ n +++++   ++
  EFC35368.1 50 NLTHLNVNENYISDKGVKFIS 70
                8**********9988877665 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.21
       LRR_1  2 LrhLdLsnnp 11
                L +L +++np
  EFC35368.1 75 LVELEIEDNP 84
                889******9 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.0078
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+hL+++ n l
  EFC35368.1  99 QLTHLNIGCNYL 110
                 59*******998 PP

  == domain 6  score: 7.6 bits;  conditional E-value: 0.0016
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++LdL++n +
  EFC35368.1 123 NLTSLDLNGNEI 134
                 8*********97 PP

  == domain 7  score: 2.7 bits;  conditional E-value: 0.063
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++L++++ +
  EFC35368.1 145 KLTYLNIGYSC 155
                 79*****8877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       393  (0.0219198); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.46u 0.31s 00:00:00.77 Elapsed: 00:00:00.48
# Mc/sec: 1105.88
//
Query:       EFC35369.1  [L=246]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.02   14.9   0.0      0.035   14.1   0.0    1.3  1  Vault_3   Major Vault Protein Repeat domain


Domain annotation for each model (and alignments):
>> Vault_3  Major Vault Protein Repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   1.9e-06     0.035       5      58 ..     171     224 ..     166     225 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.9e-06
     Vault_3   5 kvphNaavqiydyktkksRvvfGPelViLePhEeftvlsLSgGkPKepnaiksl 58 
                 ++  N +vq y+  +++ Rv   P+  + +P  +f v  LS+     +n i s+
  EFC35369.1 171 QLHYNYLVQYYNHYSNTHRVFDTPKNPLTNPRTQFYVGLLSADLYQASNLITSI 224
                 45679************************************9888888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       703  (0.0392102); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1462.97
//
Query:       EFC35370.1  [L=101]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.076   13.9   1.2      0.087   13.7   1.2    1.2  1  DUF4065   Protein of unknown function (DUF4065)


Domain annotation for each model (and alignments):
>> DUF4065  Protein of unknown function (DUF4065)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   1.2   4.9e-06     0.087      47      96 ..      35      80 ..       8      93 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 4.9e-06
     DUF4065 47 kpieekeeeisdeklekkekkeveeleddkeae.........lseeekevidkvikkyk 96
                ++i++++++  ++ +++++             +         l+eee+e+  kv++k++
  EFC35370.1 35 NNIDNNNNTLDNNSIDNNN-------------NkkeikledlLTEEEIEIASKVLEKLS 80
                2223333333333332222.............1244446677**************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (101 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1695  (0.0945396); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 630.98
//
Query:       EFC35371.1  [L=200]
Description: hypothetical protein NAEGRDRAFT_60098 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.9e-49  166.1   8.7    8.2e-29  100.8   0.3    2.1  2  MTP18     Mitochondrial 18 KDa protein (MTP18)


Domain annotation for each model (and alignments):
>> MTP18  Mitochondrial 18 KDa protein (MTP18)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.8   0.3   4.6e-33   8.2e-29       1      71 [.      36     106 ..      36     112 .. 0.94
   2 !   70.3   2.6     1e-23   1.9e-19     101     171 .]     109     177 ..     100     177 .. 0.87

  Alignments for each domain:
  == domain 1  score: 100.8 bits;  conditional E-value: 4.6e-33
       MTP18   1 selryaayaarlrtillsahRyvaytsdigEsfrPvahpalVkaaYgiswaYilgDvayegykaklrneea 71 
                 s+lry++y+ rl+t+++++ Ry+aytsd+gE+frP++hp +V+a+YgiswaY+lgDv+ ++y++k + +++
  EFC35371.1  36 SSLRYLGYLGRLKTAIVAGARYLAYTSDVGEAFRPIVHPLIVRAGYGISWAYVLGDVGIQTYREKEKGSST 106
                 579************************************************************99987765 PP

  == domain 2  score: 70.3 bits;  conditional E-value: 1e-23
       MTP18 101 yrlvmakravFqsiASmaLPaltiHsvVkysgkalknvknkrlrtwgpialgLavvPaLpylfDepveeav 171
                 +  +++k a+Fqs+ASm+LP++tiH++V+  + +lk+v  k   ++ p++ gLav+PaLp++fD+pve++v
  EFC35371.1 109 VLRTATKTAIFQSTASMILPMITIHQTVHVVSAILKKVGYKS--KVIPTISGLAVIPALPFMFDHPVEHFV 177
                 4446899******************************95543..467**********************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       655  (0.036533); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1262.40
//
Query:       EFC35372.1  [L=103]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.14   11.0   0.0       0.17   10.7   0.0    1.1  1  Trp_syntA  Tryptophan synthase alpha chain


Domain annotation for each model (and alignments):
>> Trp_syntA  Tryptophan synthase alpha chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   9.3e-06      0.17     199     229 ..       5      35 ..       2      55 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 9.3e-06
                 S-EEEESSS-SHHHHHHHHTT-SEEEE-HHH CS
   Trp_syntA 199 vPvavGFGistkeqvkqvakvadGvivGSal 229
                  P+ vG+Gi++++q k+v  + +G +v  ++
  EFC35372.1   5 EPIVVGYGIKREDQPKTVLIIKEGSVVDAKV 35 
                 6***********************9997765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       407  (0.0227007); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.29s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 708.92
//
Query:       EFC35373.1  [L=108]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1421  (0.0792571); expected 358.6 (0.02)
Passed bias filter:                      835  (0.0465726); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.32s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 673.94
//
Query:       EFC35374.1  [L=106]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0057   16.7   5.4     0.0057   16.7   5.4    1.4  1  PRIMA1          Proline-rich membrane anchor 1
  ------ inclusion threshold ------
      0.024   13.4   0.7      0.024   13.4   0.7    1.1  1  Sarcoglycan_2   Sarcoglycan alpha/epsilon
       0.03   14.3   0.0      0.032   14.3   0.0    1.1  1  Halogen_Hydrol  5-bromo-4-chloroindolyl phosphate hydrolysis 
      0.037   14.1   0.3      0.047   13.8   0.3    1.2  1  DUF3278         Protein of unknown function (DUF3278)
      0.078   12.6   0.5      0.093   12.3   0.5    1.3  1  SLATT_6         SMODS and SLOG-associating 2TM effector domai
       0.12   13.3   0.4       0.19   12.6   0.4    1.5  1  EphA2_TM        Ephrin type-A receptor 2 transmembrane domain
       0.14   12.4   3.7       0.19   12.0   3.6    1.4  1  Orf78           Orf78 (ac78)


Domain annotation for each model (and alignments):
>> PRIMA1  Proline-rich membrane anchor 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   5.4   2.2e-06    0.0057      45      92 ..      17      66 ..       9      84 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.2e-06
      PRIMA1 45 taaestvsple.pwwselviiiavvcaslvfllvl.viicykaikrkplr 92
                ++ +  v+++  + +++++ii +vvcas + l+++ +i  y  i rk  r
  EFC35374.1 17 QVLNKVVVQVGtNSFTDVIIICSVVCASCLILILVgIIALYLCILRKKRR 66
                5556666666657789************9888777255579999998655 PP

>> Sarcoglycan_2  Sarcoglycan alpha/epsilon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.7   9.5e-06     0.024     290     346 ..      29      88 ..      11     105 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 9.5e-06
  Sarcoglycan_2 290 RnYideiai.slaiPglilllLlgiLsailClqhekl.....keessvekdnpatsdvqlvqy 346
                     +++d i+i s++  + ++l+L+gi++  lC+ ++k      +e+  +e++++   + qlv +
     EFC35374.1  29 NSFTDVIIIcSVVCASCLILILVGIIALYLCILRKKRryylqREDVDTESQHM---KRQLVFH 88 
                    5666665552677788999*************999986665422222222222...2344422 PP

>> Halogen_Hydrol  5-bromo-4-chloroindolyl phosphate hydrolysis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   1.2e-05     0.032      26      70 ..      41      86 ..      12     103 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.2e-05
  Halogen_Hydrol 26 fflallia.ilggilvyvasrknkkkkhlkksglsrkelkyiretl 70
                    + +++li+ ++g+i++y+ + ++k++++l++++++++++++ r+ +
      EFC35374.1 41 VCASCLILiLVGIIALYLCILRKKRRYYLQREDVDTESQHMKRQLV 86
                    22336666699999******99*********999999865555444 PP

>> DUF3278  Protein of unknown function (DUF3278)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.3   1.8e-05     0.047      51     116 ..      22      91 ..      10      95 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.8e-05
     DUF3278  51 valllakktpeselilglvl...tnlllvvlvsglY..iliaskklglatkeveakdyekavkkivlksik 116
                 v++ ++ ++ ++ +i+  v+   + +l+ v++  lY  il++ +++ l+ ++v++++ ++ ++++v++  k
  EFC35374.1  22 VVVQVGTNSFTDVIIICSVVcasCLILILVGIIALYlcILRKKRRYYLQREDVDTES-QHMKRQLVFHTSK 91 
                 44444444444444333333222233444445555544899**************99.7788888888765 PP

>> SLATT_6  SMODS and SLOG-associating 2TM effector domain 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.5   3.6e-05     0.093      61     110 ..      45      95 ..      10     104 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.6e-05
     SLATT_6  61 salliiigiialyisayekdkekYekagkeltklfneLkelysevks.see 110
                  ++li++giialy+ +  k+++ Y +     t+  +  ++l +++ + s++
  EFC35374.1  45 CLILILVGIIALYLCILRKKRRYYLQREDVDTESQHMKRQLVFHTSKlSDS 95 
                 458999***********9999999776655555555445554444442444 PP

>> EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.4   7.5e-05      0.19       4      44 ..      42      79 ..      34     104 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 7.5e-05
    EphA2_TM  4 aavaglvllvilvilvlvlvrrrsknrkqksdlkskeekke 44
                 a   +++lv +++l+l+++r+++++  q++d    +++++
  EFC35374.1 42 CASCLILILVGIIALYLCILRKKRRYYLQREDV---DTESQ 79
                333344555555666666666666666666553...22222 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   3.6   7.6e-05      0.19      59      99 ..      28      71 ..       7      81 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 7.6e-05
       Orf78 59 kaqaln.illisllavvcvlvll..yviyYfvilrerqkssvke 99
                ++++++ i++ s+++  c++++l  ++ +Y  ilr+++++  ++
  EFC35374.1 28 TNSFTDvIIICSVVCASCLILILvgIIALYLCILRKKRRYYLQR 71
                3444440555677777787777755566899****998887644 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (106 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1229  (0.0685482); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.50u 0.33s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 652.53
//
Query:       EFC35375.1  [L=200]
Description: rop family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.3e-47  159.0   0.1    8.5e-47  158.8   0.1    1.0  1  Ras       Ras family
    1.6e-19   70.3   0.0    2.5e-19   69.7   0.0    1.3  1  Roc       Ras of Complex, Roc, domain of DAPkinase
    2.4e-10   40.2   0.0      3e-10   39.8   0.0    1.1  1  Arf       ADP-ribosylation factor family
  ------ inclusion threshold ------
      0.033   13.7   0.0      0.055   13.0   0.0    1.4  1  AAA_7     P-loop containing dynein motor region


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.8   0.1   1.9e-50   8.5e-47       1     160 [.       6     175 ..       6     177 .. 0.98

  Alignments for each domain:
  == domain 1  score: 158.8 bits;  conditional E-value: 1.9e-50
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 K+v +Gd++vGKt++l+++++++F+ee+ +T  +d++t+ +e++++++++++wDT Gq++ +s+r+ +y++a+ +l+++++ +r+sfe+vk kwv+e++
  EFC35375.1   6 KCVNIGDTGVGKTCVLVSYTENEFPEEHVPTA-FDNFTSIVEYKNNRYNVQLWDTSGQDN-DSMRPISYNGAHIFLIFFSLVDRKSFERVKdKWVKELE 102
                 8999****************************.*************************97.99************************************ PP

                 HHSTTTSEEEEEEETTTGGG..........G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee..........kravsteegeelakelg.lkfletSAktnenveeafeellrei 160
                 ++ + ++p ++vGnK Dl++          ++ v+++egeelak++g l ++e+SAkt++++ e+fe++++++
  EFC35375.1 103 ETSHIDLPYIIVGNKLDLRDdthtlkqlgvTNPVTRKEGEELAKKVGaLSYMECSAKTQTGLGEVFEAAVKAV 175
                 ****99*****************************************9*********************9987 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.7   0.0   5.6e-23   2.5e-19       1     120 []       6     120 ..       6     120 .. 0.84

  Alignments for each domain:
  == domain 1  score: 69.7 bits;  conditional E-value: 5.6e-23
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCH. CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenl. 95 
                 K v +Gd+gvGKt+ l +++e++f e++ +t   +f++  +++   ++n    +++++++WDt+Gq++ +s++p+ +++a+++++++    ++s+e++ 
  EFC35375.1   6 KCVNIGDTGVGKTCVLVSYTENEFPEEHVPTAFDNFTS--IVE---YKN----NRYNVQLWDTSGQDN-DSMRPISYNGAHIFLIFFSlvdRKSFERVk 94 
                 7789**************************99888854..323...232....4689*********86.899************987555377888873 PP

                 HHHHHHHHHHCS.SS-EEEEEE-TTT CS
         Roc  96 keWlkelkkvag.kspvilvgnkiDl 120
                 ++W+kel++ ++ + p i+vgnk+Dl
  EFC35375.1  95 DKWVKELEETSHiDLPYIIVGNKLDL 120
                 68*******999455*********95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.8   0.0   6.6e-14     3e-10      14     170 ..       4     170 ..       1     175 [. 0.74

  Alignments for each domain:
  == domain 1  score: 39.8 bits;  conditional E-value: 6.6e-14
                 EEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEE.EEETT..EEEEEEEE-SSG..GGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHH CS
         Arf  14 elrilllGLDnaGKtTilkklkleelvt.tvPTigfnvee.leikn..lkftvwDvGGqe..klRplWknYfektdavifvvDsadreRleeakeeLka 106
                  ++++ +G  + GKt +l  ++++e+ + +vPT   n  + +e+kn  +++++wD  Gq+  ++Rp+  +Y  +   +if    +dr+ +e  k++  +
  EFC35375.1   4 TIKCVNIGDTGVGKTCVLVSYTENEFPEeHVPTAFDNFTSiVEYKNnrYNVQLWDTSGQDndSMRPI--SYNGAHIFLIFF-SLVDRKSFERVKDKWVK 99 
                 689999**99***************96559***99997762678762367889*****972257776..666665556653.56677788888888889 PP

                 HCTSGCCTTSEEEEEEE-TTSTTSS-HHH...HHHHTTGGG....SSSSSSEEEEEEBTTTTBTHHHHHHH CS
         Arf 107 lleeeelkevallvlaNKqDlpealseee...lrellglee....lkgkrkleiqkcsavkgeglkeglew 170
                  lee    + + ++++NK Dl+++ ++ +   +++ ++ +e     k+   l+ ++csa +++gl e +e 
  EFC35375.1 100 ELEETSHIDLPYIIVGNKLDLRDDTHTLKqlgVTNPVTRKEgeelAKKVGALSYMECSAKTQTGLGEVFEA 170
                 99999999*************98765433111333333333555334667889999******999999876 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   1.2e-05     0.055      34      72 ..       5      44 ..       1      54 [. 0.79

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
       AAA_7 34 kpvllvGptGtGKtviikd.llkkldkekylsltinfsaq 72
                 +++ +G+tG+GKt+++ + + +++++e++ +++ nf++ 
  EFC35375.1  5 IKCVNIGDTGVGKTCVLVSyTENEFPEEHVPTAFDNFTSI 44
                567889***********99666778888877788888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       838  (0.0467399); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1365.45
//
Query:       EFC35376.1  [L=143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.5e-19   69.0   0.4    4.2e-19   68.7   0.4    1.1  1  Ras          Ras family
    5.9e-09   35.6   0.2    7.2e-09   35.3   0.2    1.1  1  Arf          ADP-ribosylation factor family
    4.9e-08   33.2   0.1    9.4e-08   32.3   0.1    1.4  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    1.1e-05   25.0   0.1    1.3e-05   24.9   0.1    1.1  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    0.00046   20.1   0.4     0.0028   17.6   0.3    2.0  2  RsgA_GTPase  RsgA GTPase
     0.0037   17.3   0.1        2.5    8.1   0.1    2.0  2  CbiA         CobQ/CobB/MinD/ParA nucleotide binding domain
  ------ inclusion threshold ------
       0.14   12.0   1.7       0.15   11.8   0.6    1.7  2  ATP_bind_1   Conserved hypothetical ATP binding protein


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.7   0.4   1.6e-22   4.2e-19       8     123 ..      17     130 ..      12     140 .. 0.91

  Alignments for each domain:
  == domain 1  score: 68.7 bits;  conditional E-value: 1.6e-22
                 TTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHST.TTS CS
         Ras   8 savGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrvae.env 105
                 ++vGKts++++f ++     y+    vd y k i vd+++ ++ei+DT   ee+++lr++++r++++++lv d+ + +s +++k ++e+i +++e +++
  EFC35376.1  17 GGVGKTSIVFQFFRNMLC--YDLSC-VDDYAKYILVDENTFRIEIFDTDAAEEYSTLRDQCIRSSKCFILVCDVFDFKSINSLKFMIEQILNIKEsNDI 112
                 69*************976..55666.8******************************************************************99889* PP

                 EEEEEEETTTGGGG-SS- CS
         Ras 106 pivLvGnKvDleekravs 123
                 piv   nK+Dl ++++++
  EFC35376.1 113 PIVFTLNKIDLINNNNLE 130
                 ***********9977665 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.3   0.2   2.8e-12   7.2e-09       7     143 ..       3     139 ..       1     142 [. 0.90

  Alignments for each domain:
  == domain 1  score: 35.3 bits;  conditional E-value: 2.8e-12
                 GGTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEE..TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHH CS
         Arf   7 klklkkkelrilllGLDnaGKtTilkklkleelvttvPTigfnveelei..knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakee 103
                 kl+ k+ ++++ ++G  + GKt i+ ++  + l      +    + + +  ++++++++D    e+   l ++  ++ +  i v D+ d + +++ k  
  EFC35376.1   3 KLHDKEYSIKCSIMG--GVGKTSIVFQFFRNMLCYDLSCVDDYAKYILVdeNTFRIEIFDTDAAEEYSTLRDQCIRSSKCFILVCDVFDFKSINSLKFM 99 
                 666777777888877..89*************9999999988888766533788899****************************************** PP

                 HHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGG CS
         Arf 104 LkalleeeelkevallvlaNKqDlpealseeelrellgle 143
                 ++++l+ +e ++++++   NK+Dl +  + ee+ e+l+++
  EFC35376.1 100 IEQILNIKESNDIPIVFTLNKIDLINNNNLEEMVEKLKMK 139
                 ************************************9987 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.3   0.1   3.7e-11   9.4e-08       8     120 .]      17     123 ..      15     123 .. 0.78

  Alignments for each domain:
  == domain 1  score: 32.3 bits;  conditional E-value: 3.7e-11
                 TTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHHHHHHHHH CS
         Roc   8 sgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlkeWlkelk 103
                 +gvGKts++ +f ++     ++  +  d+++  +  +++       ++++++i+Dt   e++++l++  +r+++++ilv+d    +s ++lk  ++++ 
  EFC35376.1  17 GGVGKTSIVFQFFRNMLC--YDLSCVDDYAKYIL--VDE-------NTFRIEIFDTDAAEEYSTLRDQCIRSSKCFILVCDvfdFKSINSLKFMIEQIL 104
                 68***********99885..44555556654433..222.......4689****************************988543556688999999998 PP

                 HHCS..SS-EEEEEE-TTT CS
         Roc 104 kvag..kspvilvgnkiDl 120
                 +  +  ++p+++  nkiDl
  EFC35376.1 105 NIKEsnDIPIVFTLNKIDL 123
                 87652155899999***95 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.1     5e-09   1.3e-05      66     150 ..      50     140 ..      18     142 .. 0.88

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 5e-09
                 TCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETT.....TBSTHHHHHHHHHHHHTTTEEEEEEESCGST.HHHHHHHHHHHHHHH CS
    GTP_EFTU  66 etkkylinliDtPGHvdFskevirglrvlDgavlvvdav.....eGvepqteevlrlalkegvpiivfiNKmDrl.kaelkeiveevkqkl 150
                 ++++++i + Dt   +++s    + +r   + +lv+d+      +  +   e++l++  ++++pi++ +NK+D + +++l+e+ve++k kl
  EFC35376.1  50 DENTFRIEIFDTDAAEEYSTLRDQCIRSSKCFILVCDVFdfksiNSLKFMIEQILNIKESNDIPIVFTLNKIDLInNNNLEEMVEKLKMKL 140
                 58999********************************9944444559999*************************999********99877 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.19   4.9e+02     108     117 ..      17      26 ..       5      38 .. 0.84
   2 !   17.6   0.3   1.1e-06    0.0028      29      72 ..      94     136 ..      66     141 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.19
                  TTSSHHHHHH CS
  RsgA_GTPase 108 SGvGKStLin 117
                   GvGK++++ 
   EFC35376.1  17 GGVGKTSIVF 26 
                  49*****985 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 1.1e-06
                  T--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHHHHHHHHHHH CS
  RsgA_GTPase  29 elslnlldrfLvlaeekgiepvivlnKiDlleeeeeleelkeel 72 
                  +  + +++++L + e+++i++v  lnKiDl+++++ lee+ e+l
   EFC35376.1  94 NSLKFMIEQILNIKESNDIPIVFTLNKIDLINNNN-LEEMVEKL 136
                  4456789***************************9.88887766 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0017       4.4       4      21 ..      13      30 ..      11      37 .. 0.84
   2 !    8.1   0.1     0.001       2.5      25     101 ..      51     137 ..      44     142 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0017
                EESSTTSSHHHHHHHHHH CS
                xxxxxxxxxxxxxxxxxx RF
        CbiA  4 astkGGvGKTtlaanLar 21
                +s  GGvGKT+++  + r
  EFC35376.1 13 CSIMGGVGKTSIVFQFFR 30
                5789********987665 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.001
                 HTT--EEEEEEEESSCCCCHHTTEB-HHHH...........CCHCCCHHHHHHCHCHHHH..EEEEEEEEESS...-TTCHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        CbiA  25 rrglrVllvDaDpqannlaileglendiep...........dlkrllellealgkkkalllkiagvvlnrvdgeneetllkealeelk 101
                 ++ +r+  +D+D   + +++ ++     ++           ++ +l+ ++e++ + k+ +  ++ + ln++d  n +++l+e++e+lk
  EFC35376.1  51 ENTFRIEIFDTDAAEEYSTLRDQCIRSSKCfilvcdvfdfkSINSLKFMIEQILNIKESNDIPIVFTLNKIDLIN-NNNLEEMVEKLK 137
                 4667888888888877777544444444449999999999999999********9999999999999*****985.888999999986 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.48   1.2e+03       5      16 ..      17      28 ..      16      40 .. 0.81
   2 ?   11.8   0.6   5.9e-05      0.15     121     177 ..      76     133 ..      32     142 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.48
  ATP_bind_1  5 aGsGKttfvgal 16
                 G+GKt++v ++
  EFC35376.1 17 GGVGKTSIVFQF 28
                599***999776 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 5.9e-05
  ATP_bind_1 121 efalvvvyLvDsqrltd..ptkfisgllsalsamlrlelPhvvvlnkfDllkek.lekel 177
                 + + + + + D+   ++  + kf+ +  + l++  + ++P v  lnk+Dl++++ le+ +
  EFC35376.1  76 RSSKCFILVCDVFDFKSinSLKFMIE--QILNIKESNDIPIVFTLNKIDLINNNnLEEMV 133
                 55678888888888888667899888..8999999***************9955433333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       784  (0.043728); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 984.04
//
Query:       EFC35377.1  [L=171]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1209  (0.0674327); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.38u 0.25s 00:00:00.63 Elapsed: 00:00:00.41
# Mc/sec: 1250.16
//
Query:       EFC35378.1  [L=295]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       537  (0.0299515); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.40u 0.26s 00:00:00.66 Elapsed: 00:00:00.41
# Mc/sec: 2150.90
//
Query:       EFC35379.1  [L=120]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-25   87.6   0.6    4.2e-25   87.6   0.6    2.0  2  IGR       IGR protein motif
  ------ inclusion threshold ------
      0.012   15.3   0.1       0.02   14.6   0.1    1.4  1  TerB_N    TerB N-terminal domain
      0.089   12.8   0.1       0.18   11.9   0.1    1.5  1  GvpG      Gas vesicle protein G


Domain annotation for each model (and alignments):
>> IGR  IGR protein motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.15   8.7e+02       6      20 ..       9      23 ..       8      52 .. 0.65
   2 !   87.6   0.6     7e-29   4.2e-25       1      55 []      55     109 ..      55     109 .. 0.99

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.15
         IGR  6 kIGRnceehaekfes 20
                 I R+++e ae  e+
  EFC35379.1  9 TIKRSYSEAAEEEED 23
                688888888876655 PP

  == domain 2  score: 87.6 bits;  conditional E-value: 7e-29
         IGR   1 etFLkkIGRnceehaekfeswekLfelsskqlkelGipvrqRRYiLrwrekyrqG 55 
                 e+FLk IG++ceeh++kf+swe+Lf+++s +lk + ipv qRR+iL+w+e+yr+G
  EFC35379.1  55 ESFLKNIGKGCEEHVDKFTSWEDLFTSKSLKLKVKEIPVAQRRWILKWLERYRKG 109
                 68***************************************************98 PP

>> TerB_N  TerB N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.1   3.4e-06      0.02      62      89 ..      89     118 ..      80     120 .] 0.88

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 3.4e-06
      TerB_N  62 sslspaqrrtYLdWlaqgRkg..pdtslsY 89 
                 ++++ aqrr+ L+Wl++ Rkg  p ++ +Y
  EFC35379.1  89 KEIPVAQRRWILKWLERYRKGevPGYPQTY 118
                 57999****************887777777 PP

>> GvpG  Gas vesicle protein G
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1     3e-05      0.18      17      44 ..      12      39 ..       8      44 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3e-05
        GvpG 17 eqvqeraeeqlddqenlrkeLaaLqqeL 44
                ++  e+aee+ dd+++lr +La+L + L
  EFC35379.1 12 RSYSEAAEEEEDDETKLRRQLANLPKPL 39
                667899*****************97755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (120 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      555  (0.0309554); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.43u 0.29s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 818.25
//
Query:       EFC35380.1  [L=200]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.3e-46  156.3   0.0      6e-46  156.1   0.0    1.0  1  Arf              ADP-ribosylation factor family
    1.2e-12   47.7   0.1    2.2e-12   46.8   0.1    1.4  2  SRPRB            Signal recognition particle receptor beta su
    4.8e-09   36.5   0.0    7.6e-09   35.8   0.0    1.3  1  Roc              Ras of Complex, Roc, domain of DAPkinase
    1.1e-08   34.8   0.0    1.3e-08   34.6   0.0    1.1  1  Ras              Ras family
    3.5e-07   29.7   1.7    0.00022   20.5   0.1    3.1  3  G-alpha          G-protein alpha subunit
    3.9e-07   30.2   0.1    5.7e-07   29.6   0.1    1.3  1  MMR_HSR1         50S ribosome-binding GTPase
    2.5e-05   23.7   0.0    3.5e-05   23.3   0.0    1.1  1  Gtr1_RagA        Gtr1/RagA G protein conserved region
    9.4e-05   22.0   0.7     0.0026   17.3   0.0    2.0  2  GTP_EFTU         Elongation factor Tu GTP binding domain
     0.0034   17.1   0.2     0.0066   16.2   0.2    1.6  1  PduV-EutP        Ethanolamine utilisation - propanediol utili
     0.0096   16.2   0.4       0.61   10.4   0.4    2.2  1  AAA_22           AAA domain
  ------ inclusion threshold ------
      0.012   15.2   0.2      0.045   13.3   0.2    1.9  1  FeoB_N           Ferrous iron transport protein B
      0.036   14.0   0.3          6    6.8   0.1    2.1  2  RsgA_GTPase      RsgA GTPase
      0.051   12.2   0.1      0.063   11.9   0.1    1.1  1  PEPCK_ATP        Phosphoenolpyruvate carboxykinase
      0.098   13.1   0.0       0.15   12.5   0.0    1.2  1  AAA              ATPase family associated with various cellul
       0.13   12.0   0.0        3.6    7.4   0.0    2.6  1  ACT              ACT domain
       0.17   11.6   0.0       0.24   11.1   0.0    1.2  1  Thymidylate_kin  Thymidylate kinase


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  156.1   0.0   5.3e-49     6e-46      12     175 .]      24     199 ..      12     199 .. 0.94

  Alignments for each domain:
  == domain 1  score: 156.1 bits;  conditional E-value: 5.3e-49
                 TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEE.TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHHCT CS
         Arf  12 kkelrilllGLDnaGKtTilkklkleelvttvPTigfnveelei.knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLkalle 109
                 + + +i++lGLDnaGKtT+l+klk++ +   + T+ +n e++ei  + +++  D+GG++ +R+lWk+Y  ++++++f+vDs+dr+R + a +eL+++l+
  EFC35380.1  24 SVKGKIIFLGLDNAGKTTLLHKLKSNLIGAYQSTTTPNKESIEIsSTCSVEAIDMGGHDLARQLWKQYCIDVNGIVFIVDSMDRKRSQVAAKELAKILN 122
                 5678***************************************955789************************************************** PP

                 SGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSS...........SSSSEEEEEEBTTTTBTHHHHHHHHHHHH CS
         Arf 110 eeelkevallvlaNKqDlpealseeelrellgleelk...........gkrkleiqkcsavkgeglkeglewlsesi 175
                 +++l++v++++l+NK D p+a+se el +++g+++l+           ++r+le++++s+++  +++e++ewl+++i
  EFC35380.1 123 DSDLANVPVVILGNKVDNPQAMSEFELCCTMGVSHLRtgptkginesnPQRPLEVFMTSIINEFNITESIEWLVSKI 199
                 ***********************************88888888889999************************9875 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.8   0.1   1.9e-15   2.2e-12       3     127 ..      26     143 ..      24     150 .. 0.78
   2 ?   -1.8   0.0       1.6   1.8e+03      50     100 ..     146     196 ..     134     197 .. 0.71

  Alignments for each domain:
  == domain 1  score: 46.8 bits;  conditional E-value: 1.9e-15
                 --EEEEE-STTSSHHHHHHHHHHS...S---B---SS-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHH CS
       SRPRB   3 kpavllvGlsdsGKTslftrLttd...svkktvtSqessaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEl 98 
                 k +++++Gl ++GKT+l+++L ++   ++++t t  ++s   ++  +   +++ iD+ Gh+ l+ +l ++  +   + g+vf+vDS +d k+ +  A  
  EFC35380.1  26 KGKIIFLGLDNAGKTTLLHKLKSNligAYQSTTTPNKES--IEI--SSTCSVEAIDMGGHD-LARQLWKQ--YCIDVNGIVFIVDS-MDRKRSQVAAKE 116
                 5689******************99443444444443333..333..56899*********8.67778888..7889*********9.689999999999 PP

                 HHHHHHHHHHHTT---EEEEEE-TTSTT- CS
       SRPRB  99 lyeilliteklkdavdiliACnKqelfla 127
                 l +il ++ +   +v+++i  nK +   a
  EFC35380.1 117 LAKILNDSDL--ANVPVVILGNKVDNPQA 143
                 ******9994..56888888899886655 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.6
                 T-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHHH CS
       SRPRB  50 kltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAElly 100
                 +++l    G  +lr+  ++ + +++  + l   + S i++ +++e  E+l+
  EFC35380.1 146 EFELCCTMGVSHLRTGPTKGINESNPQRPLEVFMTSIINEFNITESIEWLV 196
                 566666667777777777777777777777556678888889999888886 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.8   0.0   6.8e-12   7.6e-09       1     119 [.      28     139 ..      28     140 .. 0.73

  Alignments for each domain:
  == domain 1  score: 35.8 bits;  conditional E-value: 6.8e-12
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K++++G  ++GKt+ll+++ ++ +    +st+  +  +    +i+        ++++++  D++G++  r+l + y+ + + +++++d   +++s+ + 
  EFC35380.1  28 KIIFLGLDNAGKTTLLHKLKSNLIGAY-QSTTTPNKESI---EIS--------STCSVEAIDMGGHDLARQLWKQYCIDVNGIVFIVDsmdRKRSQVAA 114
                 9******************98877555.55544443332...222........368999***************************9955322233334 PP

                 HHHHHHHHH..CSSS-EEEEEE-TT CS
         Roc  97 eWlkelkkv..agkspvilvgnkiD 119
                 + l ++ +     + pv+++gnk+D
  EFC35380.1 115 KELAKILNDsdLANVPVVILGNKVD 139
                 4455554441245779********9 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.6   0.0   1.2e-11   1.3e-08       1     158 [.      28     197 ..      28     200 .] 0.69

  Alignments for each domain:
  == domain 1  score: 34.6 bits;  conditional E-value: 1.2e-11
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTB.HHHHHTHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvydits.resfenvkkwveeik 98 
                 K++++G  + GKt+ll++  ++     y+sT      +++ie+ ++++++e  D  G +  ++l ++y  d++gi+ + d  + ++s   +k++ + ++
  EFC35380.1  28 KIIFLGLDNAGKTTLLHKLKSN-LIGAYQSTT--TPNKESIEI-SSTCSVEAIDMGGHDLARQLWKQYCIDVNGIVFIVDSMDrKRSQVAAKELAKILN 122
                 89***************98665.566777777..344555665.5789**************************9877765550555555556655555 PP

                 HHSTTTSEEEEEEETTTGGG...............G-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee...............kravsteegeelakelglkfletSAktnenveeafeellr 158
                 +    nvp+v++GnKvD  +                r+  t+  +e   +  l+ + tS  ++ n++e +e l++
  EFC35380.1 123 DSDLANVPVVILGNKVDNPQamsefelcctmgvshLRTGPTKGINESNPQRPLEVFMTSIINEFNITESIEWLVS 197
                 555599***********9887777777776665432333333333333333356666666666666666666665 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.1    0.0025       2.8      24      44 ..      27      47 ..      20      52 .. 0.87
   2 !   20.5   0.1     2e-07   0.00022     180     280 ..      49     139 ..      47     140 .. 0.88
   3 ?   -1.0   0.0      0.69   7.8e+02     323     348 ..     168     193 ..     163     199 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0025
                EEEEEEESTTSSHHHHHHHHH CS
     G-alpha 24 vkllllGqseSGKsTilkqlk 44
                 k+++lG +  GK+T+l +lk
  EFC35380.1 27 GKIIFLGLDNAGKTTLLHKLK 47
                49***************9998 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 2e-07
                 HHHCS-----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE- CS
     G-alpha 180 DilkarlktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnK 278
                 +++ a + t+  ++ ++e++s+ +++ +d+gG+   r+ W+++  dv+ i+F+v         + d+   r + + k   +i+n + l+n+p++++ nK
  EFC35380.1  49 NLIGAYQSTTTPNKESIEISSTCSVEAIDMGGHDLARQLWKQYCIDVNGIVFIVD--------SMDR--KRSQVAAKELAKILNDSDLANVPVVILGNK 137
                 5677888999999999*************************************97........3444..566668899999999999999999999999 PP

                 HH CS
     G-alpha 279 lD 280
                 +D
  EFC35380.1 138 VD 139
                 99 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.69
                 CESGGSCEEEEEE-TT-HHHHHHHHH CS
     G-alpha 323 ksnnrrkiythftsatdtkevqkvie 348
                 +sn++r + +++ts++++ ++ + ie
  EFC35380.1 168 ESNPQRPLEVFMTSIINEFNITESIE 193
                 46888899999999999999998886 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6   0.1   5.1e-10   5.7e-07       1     114 []      28     137 ..      28     137 .. 0.70

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 5.1e-10
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETT.EEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT..TTCSHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkg.keielvDtpGliegaseekglgkaflaleeadlillvvdas..eeklkpldee 96 
                 +++++G  N+GK+tL+ +l  +   +++++ tT ++n++ ++++   ++e +D+ G  +     ++l k+++  ++++ i+++vd+   +   +   +e
  EFC35380.1  28 KIIFLGLDNAGKTTLLHKLKSN--LIGAYQSTT-TPNKESIEISStCSVEAIDMGG-HD---LARQLWKQYC--IDVNGIVFIVDSMdrK-RSQVAAKE 116
                 5899***************764..555555444.55666666555589********.44...4557777777..5789*******55531.23335577 PP

                 HHHHHHH...TTSEEEEEEES CS
    MMR_HSR1  97 leellee...akkplilvlnk 114
                 l+++l++   a+ p++++ nk
  EFC35380.1 117 LAKILNDsdlANVPVVILGNK 137
                 777776666777777777665 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.0   3.1e-08   3.5e-05       1     162 [.      28     185 ..      28     187 .. 0.72

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 3.1e-08
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletl 98 
                 k++++G  ++GKt++      ++  + +   ++t+  +k+++++++   ++ +D+gG +   +       ++   +v+ +++++D+ +r+  + + ++l
  EFC35380.1  28 KIIFLGLDNAGKTTLLH----KLKSNLIGAYQSTTTPNKESIEISSTCSVEAIDMGGHDLARQL-----WKQYCIDVNGIVFIVDSMDRKrSQVAAKEL 117
                 899**********9865....566666677899************************8754433.....3556779***********665234444444 PP

   Gtr1_RagA  99 keilealrqys..peakvfvlihKmDliqedereeifeerkeeireeiekleke......eiqffaTSiwde 162
                  +i     + s   ++ v +l +K+D+ q + + e+  ++  +  ++    + +       +++f+TSi +e
  EFC35380.1 118 AKI----LNDSdlANVPVVILGNKVDNPQAMSEFELCCTMGVSHLRTGPTKGINesnpqrPLEVFMTSIINE 185
                 444....444401456677777*******9999888777665555544432222345666899999999875 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.2     0.034        38       6      26 ..      29      49 ..      27      67 .. 0.75
   2 !   17.3   0.0   2.3e-06    0.0026      68     192 ..      69     199 ..      54     200 .] 0.74

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.034
                EEEEESTTSSHHHHHHHHHHH CS
    GTP_EFTU  6 igiighvDhGKtTLtdrLlyk 26
                i+++g  ++GKtTL+ +L  +
  EFC35380.1 29 IIFLGLDNAGKTTLLHKLKSN 49
                566777789******999765 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 2.3e-06
                 SSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB..STHHHHHHHHHHHH...TTTEEEEEEESCGST..HHHHHHHHHHHHHHHHHH.HHHHH CS
    GTP_EFTU  68 kkylinliDtPGHvdFskevirglrvlDgavlvvdaveG..vepqteevlrlalk...egvpiivfiNKmDrl..kaelkeiveevkqklsrk.eekle 158
                 +++ +  iD  GH    +   +    ++g v++vd+++    ++  +e+++++++    +vp++++ NK+D++   +e++ + ++  ++l++  ++ ++
  EFC35380.1  69 STCSVEAIDMGGHDLARQLWKQYCIDVNGIVFIVDSMDRkrSQVAAKELAKILNDsdlANVPVVILGNKVDNPqaMSEFELCCTMGVSHLRTGpTKGIN 167
                 67888999999998888888888999***********884434445666666665111566699999******8899********99999544333333 PP

                 HHHHTTTTTEEEEEEBTTTTBTHHHHHHHHHHHS CS
    GTP_EFTU 159 kygekgekevpvvfgSalkgegvktllealvell 192
                 +   +  +  +v+++S ++ +++++ +e lv+++
  EFC35380.1 168 ESNPQ--RPLEVFMTSIINEFNITESIEWLVSKI 199
                 33322..579999999999999999998888765 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.2   5.9e-06    0.0066       2      35 ..      27      61 ..      26     150 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 5.9e-06
   PduV-EutP  2 kkilliGkvgsGKttLtqalkgeel.kYkktqaie 35
                 ki+++G  ++GKttL ++lk + +  Y++t + +
  EFC35380.1 27 GKIIFLGLDNAGKTTLLHKLKSNLIgAYQSTTTPN 61
                59*******************98885699986533 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.4   0.00054      0.61       8     127 ..      29     133 ..      22     140 .. 0.49

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00054
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaee..erpevv..fvtlpsst...sskdllrellralglelkaerlsseellealeqalraravielliiDE 99 
                 ++  G   +GKTtll +l+++l   a++ +  +++e +  + t++++    +  dl+r                     ++  q++ +     ++i+D 
  EFC35380.1  29 IIFLGLDNAGKTTLLHKLKSNLI-GAYQSTttPNKESIeiSSTCSVEAidmGGHDLAR---------------------QLWKQYCIDVNG-IVFIVDS 104
                 66667777899999999998883.3333332422222222333333333233333333.....................344444444444.5555555 PP

      AAA_22 100 aqhlrseealeeLrsllnl.srkgvqliL 127
                 +++ rs+ a +eL ++ln+ +  +v++++
  EFC35380.1 105 MDRKRSQVAAKELAKILNDsDLANVPVVI 133
                 55543455555555555544455555554 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.2     4e-05     0.045       2      56 ..      28      80 ..      27     144 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 4e-05
                EEEEEESTTSSHHHHHHHHHTTSEEEEESTTSSSEEEEEEEEETTEEEEEEE--- CS
      FeoB_N  2 tvalvGnpnvGkttlfnaltgakqkvgNwpGvtvekkegklklkgkeveivDlPG 56
                +++++G  n+Gkttl+ +l   ++ +g ++ +t  +ke     ++ +ve +D+ G
  EFC35380.1 28 KIIFLGLDNAGKTTLLHKLK--SNLIGAYQSTTTPNKESIEISSTCSVEAIDMGG 80
                58899*************96..5789****9999888776666889999999977 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.1    0.0053         6      97     124 ..      25      51 ..      12      79 .. 0.78
   2 ?    5.6   0.0     0.012        14      19      63 ..      99     145 ..      81     162 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0053
                  CTTSEEEEECSTTSSHHHHHHHHCTT-- CS
  RsgA_GTPase  97 lkdktsvlvGqSGvGKStLinallpele 124
                  +k+k ++++G   +GK+tL+ +l+++l 
   EFC35380.1  25 VKGK-IIFLGLDNAGKTTLLHKLKSNLI 51 
                  4554.5899**************99854 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.012
                  EEEEEESTT..TT--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHH CS
  RsgA_GTPase  19 llivvslke..pelslnlldrfLvlaeekgiepvivlnKiDlleeee 63 
                  ++iv s+++   ++  + l ++L     +++++vi+ nK+D  + ++
   EFC35380.1  99 VFIVDSMDRkrSQVAAKELAKILNDSDLANVPVVILGNKVDNPQAMS 145
                  5677777651146778899**********************887766 PP

>> PEPCK_ATP  Phosphoenolpyruvate carboxykinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   5.6e-05     0.063     187     243 ..       9      59 ..       2      94 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.6e-05
                 HHHHHHHTT-EEEEEEEEE-T.TS-EEEEEE-TTSSHHHHH-BTTB-EEESSEEEE- CS
   PEPCK_ATP 187 mnyllpkkgvlsmhcsanvgekkgdvalfFGLSGtGKTtLsadperkligdDehgws 243
                 +ny+    ++l++ +s +         +f+GL  +GKTtL    + +lig  +   +
  EFC35380.1   9 LNYCSDLLKLLGLMSSVKGK------IIFLGLDNAGKTTLLHKLKSNLIGAYQSTTT 59 
                 56666666677776665433......59*********************97665555 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   0.00013      0.15       2     116 ..      30     142 ..      29     148 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00013
                 EEESSTTSSHHHHHHHHHHHH..........THEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHH CS
         AAA   2 llyGppGtGKTllakavakel..........gvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLl 90 
                 ++ G    GKT+l + + ++l          + e +eis +  ++ +   + +  r+l+k+        i+fi  +d++ ++r       ++ ++++L 
  EFC35380.1  30 IFLGLDNAGKTTLLHKLKSNLigayqstttpNKESIEISSTCSVEAIDMGGHDLARQLWKQYCIDV-NGIVFI--VDSMDRKR-------SQVAAKELA 118
                 78899999************8776666665556688888888886666677888899999976665.688888..88888888.......788999*** PP

                 HHHHHTTTSSSTEEEEEEESSGGGST CS
         AAA  91 teldgvkkkeskvivigatnrpdkld 116
                 + l++ +   ++v v++ +n++d+++
  EFC35380.1 119 KILNDSDL--ANVPVVILGNKVDNPQ 142
                 ****9999..58********999865 PP

>> ACT  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.0    0.0032       3.6      40      66 ..      95     121 ..      40     122 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0032
                 ECEEEEEEEEEEHHHHHHHHHHHHTTC CS
         ACT  40 vagivfvvivvdeedleevlealkkle 66 
                 v+givf+v+  d ++ + + ++l k++
  EFC35380.1  95 VNGIVFIVDSMDRKRSQVAAKELAKIL 121
                 4799******************99986 PP

>> Thymidylate_kin  Thymidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00021      0.24       3      32 ..      33      61 ..      31      72 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00021
                     ESTTSSHHHHHHHHHHHHHHTTE.EEEESS CS
  Thymidylate_kin  3 GlDGaGKttqaellkerlkeegikvvltre 32
                     GlD aGKtt + +lk+ l  +  +  +t+ 
       EFC35380.1 33 GLDNAGKTTLLHKLKSNLIGAYQS-TTTPN 61
                     9*****************998865.33333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1174.84
//
Query:       EFC35381.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0067   16.7   1.0       0.27   11.5   1.0    2.2  1  Ependymin  Ependymin


Domain annotation for each model (and alignments):
>> Ependymin  Ependymin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   1.0   1.5e-05      0.27      10      75 ..      78     144 ..      73     180 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1.5e-05
   Ependymin  10 lllfkekveYeidlktksCkkkklkepfrplevpdnatflgqvvl.Gsssapgegvlvnswsgklee 75 
                 ++ +   ++Y++  ++++C++ +l  +  p++  +natf g+ v+ G +    ++++ + w++++ +
  EFC35381.1  78 IQIHAGFTQYSFYPHNNTCNVVELGFNPLPYNWLQNATFAGNQVVnGVNCRVWKRLTSTYWEDETDG 144
                 77888889********************************976552666666666666666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       449  (0.0250432); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1067.44
//
Query:       EFC35382.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-10   41.5   0.1    3.5e-10   40.6   0.1    1.4  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.6   0.1   1.9e-14   3.5e-10       3      91 ..     144     237 ..     142     239 .. 0.79

  Alignments for each domain:
  == domain 1  score: 40.6 bits;  conditional E-value: 1.9e-14
                     EEEE-TT-EEEEE-SS--.--TT.-.EEEEEEEEE......ET-B--EEE.............---TT-EEEEE-..B-TEEE--B.-SS-EEEE CS
  2OG-FeII_Oxy_3   3 vlrygegqeykpHvDnfe.keegsgqrrltvllyLne..keseeGGelelyekdk...eavkikpkkgrlvlFesdellpHevlpvtkggeRlsl 91 
                     + +y++g+++++HvD +  +++++ +  lt+++yLn+  + ++eGG   +y+++      +  +p  + l++ ++d+   H++++v kg  ++++
      EFC35382.1 144 LCKYKPGHYFNKHVDGSFeDHKNKTKSYLTLIIYLNSqlDGEFEGGSTIFYDSRMelmTRKVTEPAGNALIFLQNDKHMLHGGEKVFKG-VKYIM 237
                     6789***********87687777799**********998888********999999944444456666666666665555******775.99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.28s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1807.99
//
Query:       EFC35383.1  [L=460]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.13   12.9   0.1        1.7    9.3   0.0    2.2  2  SPT6_acidic  Acidic N-terminal SPT6


Domain annotation for each model (and alignments):
>> SPT6_acidic  Acidic N-terminal SPT6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.0   9.3e-05       1.7       9      74 ..     103     173 ..     100     178 .. 0.63
   2 ?    0.8   0.0     0.042   7.6e+02      18      32 ..     218     232 ..     206     237 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 9.3e-05
  SPT6_acidic   9 deeeerkvregFIvddd..eeeeeeeesee..eeekkrrkkkkkrre....eeedaLdedDldLieentgvkvk 74 
                  d++++  + + FI ++d       ++++++  +e+ kr+   ++  +     e+  L  +D dL   n  ++ k
   EFC35383.1 103 DKQKATTIDDSFIINNDlsP--TGTNGDDSpiTETPKRKHDNRQP-SsikkLESYLLQSEDCDLFLTNIPENLK 173
                  8999************9642..33333332223333333333333.246544447999*****99888877665 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.042
  SPT6_acidic  18 egFIvdddeeeeeee 32 
                    F  ddde+ ++++
   EFC35383.1 218 TKFMNDDDEDISNTK 232
                  578889888866554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       580  (0.0323498); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 2793.67
//
Query:       EFC35384.1  [L=230]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.3e-16   57.6   0.0    3.7e-07   29.9   0.0    3.0  3  Biotin_lipoyl    Biotin-requiring enzyme
    2.5e-07   30.4   0.0    0.00035   20.4   0.0    3.3  3  Biotin_lipoyl_2  Biotin-lipoyl like
  ------ inclusion threshold ------
      0.015   15.1   0.0       0.23   11.2   0.0    2.7  3  PTS_EIIA_1       phosphoenolpyruvate-dependent sugar phosphot
      0.073   13.0   0.0        4.3    7.2   0.0    2.2  2  GCV_H            Glycine cleavage H-protein
       0.13   11.6   0.0        1.1    8.7   0.0    2.0  2  NQRA             Na(+)-translocating NADH-quinone reductase s
       0.18   11.9   0.0       0.51   10.4   0.0    1.7  2  QRPTase_N        Quinolinate phosphoribosyl transferase, N-te


Domain annotation for each model (and alignments):
>> Biotin_lipoyl  Biotin-requiring enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.09   2.7e+02      44      73 .]      11      40 ..       9      40 .. 0.91
   2 !   22.6   0.0   2.4e-08   7.1e-05      13      64 ..      54     106 ..      49     108 .. 0.95
   3 !   29.9   0.0   1.3e-10   3.7e-07      11      59 ..     165     214 ..     161     226 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.09
                   EEEBSSSEEEEEESSTTTEEE-TTCEEEEE CS
  Biotin_lipoyl 44 eieapkaGvvkeilvkeGdtvevgdllaki 73
                   e+++ ++G ++ ++  e+ t++ +d l+ +
     EFC35384.1 11 ELTSMVEGLITPLMRGEDLTITNSDYLFDL 40
                   79999*****************99999875 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 2.4e-08
                    EE..ECSESSSTTCEE-TTSEEEEEECTTEEEEEEBSSSEEEEEESSTTTEEE CS
  Biotin_lipoyl  13 eeg.vvevlvkvGdkVkagqvlaeveamKmemeieapkaGvvkeilvkeGdtv 64 
                    +eg ++++lvk+Gd V+ +q  ++ve  K + e +  k G++ e+  k+Gd v
     EFC35384.1  54 REGkILQFLVKPGDWVERNQAGIIVEREKKVEEWKFLKPGRILEVNLKVGDHV 106
                    678899*********************************************98 PP

  == domain 3  score: 29.9 bits;  conditional E-value: 1.3e-10
                    EEEE..ECSESSSTTCEE-TTSEEEEEECTTEEEEEEBSSSEEEEEESST CS
  Biotin_lipoyl  11 sveeg.vvevlvkvGdkVkagqvlaeveamKmemeieapkaGvvkeilvk 59 
                    +++e   +e+lvk+G+ Vk+g+ l+  ++ K+  e+ +p +G+++ +  +
     EFC35384.1 165 YYTEIyDIEWLVKEGQLVKKGDLLCSYQVPKLRLEFMSPYDGKIVWLRRD 214
                    56666779************************************987766 PP

>> Biotin_lipoyl_2  Biotin-lipoyl like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.17   5.1e+02      11      25 ..      56      70 ..      52      74 .. 0.87
   2 !    5.1   0.0    0.0069        21      10      24 ..      92     106 ..      89     107 .. 0.94
   3 !   20.4   0.0   1.2e-07   0.00035      15      39 ..     173     197 ..     172     200 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.17
  Biotin_lipoyl_2 11 GrVaqlnVkdGqrVk 25
                     G++ q +Vk G+ V+
       EFC35384.1 56 GKILQFLVKPGDWVE 70
                     999999***999886 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0069
  Biotin_lipoyl_2  10 sGrVaqlnVkdGqrV 24 
                      +Gr+ ++n k G++V
       EFC35384.1  92 PGRILEVNLKVGDHV 106
                      7*************9 PP

  == domain 3  score: 20.4 bits;  conditional E-value: 1.2e-07
  Biotin_lipoyl_2  15 qlnVkdGqrVkaGdvLaelDsralq 39 
                      +++Vk+Gq Vk+Gd+L     ++l+
       EFC35384.1 173 EWLVKEGQLVKKGDLLCSYQVPKLR 197
                      69**************887766665 PP

>> PTS_EIIA_1  phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.58   1.7e+03      80      99 ..      55      74 ..      49      86 .. 0.78
   2 ?   11.2   0.0   7.9e-05      0.23      72     109 ..     158     197 ..     156     203 .. 0.82
   3 ?    0.7   0.0      0.14   4.2e+02      39      53 ..     199     213 ..     193     229 .. 0.62

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.58
                TTTTEEES----SEE-SEEE CS
  PTS_EIIA_1 80 kgegFellvkegdkVkagdk 99
                +g+  + lvk gd V++++ 
  EFC35384.1 55 EGKILQFLVKPGDWVERNQA 74
                68888999999999998876 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 7.9e-05
                 -SSSTTTTTTTTE..EES----SEE-SEEEEEEE-HHHHG CS
  PTS_EIIA_1  72 iGidtvklkgegF..ellvkegdkVkagdklvevdleaik 109
                 +Gi t +   e +  e lvkeg+ Vk+gd+l+++++ +++
  EFC35384.1 158 CGISTKEYYTEIYdiEWLVKEGQLVKKGDLLCSYQVPKLR 197
                 688888888877744679***************9998876 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.14
                 EEEES--EEEEE--S CS
  PTS_EIIA_1  39 kvvapvdGkvekvfp 53 
                 ++++p dGk++ +  
  EFC35384.1 199 EFMSPYDGKIVWLRR 213
                 688899999887655 PP

>> GCV_H  Glycine cleavage H-protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0    0.0014       4.3      23      83 ..      48     107 ..      38     113 .. 0.86
   2 ?    3.5   0.0     0.021        62      38      72 ..     175     209 ..     157     214 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0014
                 -HHHHHHH-SEEEEE---TT-EE-TT-EEEEEEESS-EEEEE-SSSEEEEEE-GGGTT-TT CS
       GCV_H  23 tdfaqeelgdvvfvelpevgtkvkkgeslaavEsvKaasevyapvsGevvevNekleeepe 83 
                 + +  ++ g+++   ++  g+ v+ +++  +vE  K++ e      G ++evN k+ ++ +
  EFC35384.1  48 STICRAREGKILQFLVK-PGDWVERNQAGIIVEREKKVEEWKFLKPGRILEVNLKVGDHVG 107
                 66677778888887665.599**********************************998765 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.021
                 ---TT-EE-TT-EEEEEEESS-EEEEE-SSSEEEE CS
       GCV_H  38 lpevgtkvkkgeslaavEsvKaasevyapvsGevv 72 
                 l ++g+ vkkg+ l +    K   e+++p +G++v
  EFC35384.1 175 LVKEGQLVKKGDLLCSYQVPKLRLEFMSPYDGKIV 209
                 6789*****************************98 PP

>> NQRA  Na(+)-translocating NADH-quinone reductase subunit A (NQRA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0     0.095   2.8e+02      40      78 ..      58      97 ..      20     103 .. 0.75
   2 ?    8.7   0.0   0.00036       1.1      41      81 ..     172     213 ..     154     217 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.095
        NQRA 40 kpklkvkegdkVk...kGqvlfedKknpgvlftspasGevve 78
                 ++ +vk gd V+   +G ++  +Kk ++ +f  p  G++ e
  EFC35384.1 58 ILQFLVKPGDWVErnqAGIIVEREKKVEEWKFLKP--GRILE 97
                56788999999962225667888999999999988..55555 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00036
        NQRA  41 pklkvkegdkVkkGqvlfedKk.npgvlftspasGevveinr 81 
                  + +vkeg+ VkkG+ l  +   +  + f+sp +G++v ++r
  EFC35384.1 172 IEWLVKEGQLVKKGDLLCSYQVpKLRLEFMSPYDGKIVWLRR 213
                 5678************998875145789*********97776 PP

>> QRPTase_N  Quinolinate phosphoribosyl transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       2.8   8.3e+03      49      62 ..      60      73 ..      50      78 .. 0.76
   2 ?   10.4   0.0   0.00017      0.51      31      67 ..     158     191 ..     156     195 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 2.8
                EESS-TT-EEETTE CS
   QRPTase_N 49 ellvkDGervekgd 62
                ++lvk G++ve+++
  EFC35384.1 60 QFLVKPGDWVERNQ 73
                56788888888776 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00017
                 -SHHHHHHHHHHHTTTEEEESS-TT-EEETTEEEEEE CS
   QRPTase_N  31 aGlevaeevfellpglevellvkDGervekgdvllei 67 
                 +G++  e   e++    +e+lvk+G+ v+kgd l+  
  EFC35384.1 158 CGISTKEYYTEIY---DIEWLVKEGQLVKKGDLLCSY 191
                 6666666666666...99**************99975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (230 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       279  (0.0155614); expected 358.6 (0.02)
Passed bias filter:                      254  (0.014167); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.43u 0.28s 00:00:00.71 Elapsed: 00:00:00.43
# Mc/sec: 1591.90
//
Query:       EFC35385.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      1e-27   97.2   0.8    1.2e-27   97.0   0.8    1.1  1  Pkinase         Protein kinase domain
    1.3e-18   67.3   0.0    1.5e-18   67.1   0.0    1.0  1  Pkinase_Tyr     Protein tyrosine kinase
    8.6e-05   21.5   0.2    9.6e-05   21.3   0.2    1.1  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.022   14.6   0.1        1.6    8.7   0.0    2.5  2  HSBP1           Heat shock factor binding protein 1


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.0   0.8   2.6e-31   1.2e-27      52     202 ..       1     168 [.       1     221 [. 0.75

  Alignments for each domain:
  == domain 1  score: 97.0 bits;  conditional E-value: 2.6e-31
                 HHHHSCTTB--EEEEEEE....SSEEEEEEE--TTEBHHHHHH...HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE....... CS
     Pkinase  52 lkklkhpnivrlyevfee....kdelylvleyveggeladlle...rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge....... 136
                 + +l+h+ iv+++++ +     k++ ++++e ++++  +++ +     +  + +++ +++  + ++l+y+H+k+iiH D+Kp NiL+ +++        
  EFC35385.1   1 MSQLDHDGIVKVFKFETItdkfKKYSLILMEKMDKDLSEHIFTdfgGLKFGKISQILFVLLDVSSSLAYCHQKRIIHYDVKPVNILLTTRKIgnvdvid 99 
                 67899*******987665668888888*******88655555554322234456788999****************************54335678888 PP

                 .EEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH...TTSCB.SHHHHHHHHHHHHHHHHHSS-STTTSSH CS
     Pkinase 137 .lKitDFGlakelesssk.ltsfvgtseYlAPEvl...keney.skkvDvWslGvilyelltgkppfsgekg 202
                  +Ki+DFG++ e+ s+     + vgt+ Y++PE+l   k+ +y  ++ D +s G++++ell+g  + +   +
  EFC35385.1 100 kVKIADFGISVEMISTIAsSAEHVGTRVYMPPEMLkkvKDIKYnYRAFDAYSFGITMFELLSGDKLDN---D 168
                 8***********99988768999************877667776899****************98866...2 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.1   0.0   3.3e-22   1.5e-18      55     258 ..       1     219 [.       1     220 [. 0.83

  Alignments for each domain:
  == domain 1  score: 67.1 bits;  conditional E-value: 3.3e-22
                  HHTS-BTTB--EEEEEE....SSSSEEEEEE--TTEBHHHHHHHT..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE........ CS
  Pkinase_Tyr  55 mkklkhpnivkllgvct....keepllivteyvkgGdLlkfLrkk..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse........ 138
                  m++l+h+ ivk+  + t     ++  li++e +++ dL++++ ++    +  +++++l + l+v++ ++y ++k+++H d+   N+Ll++        
   EFC35385.1   1 MSQLDHDGIVKVFKFETitdkFKKYSLILMEKMDK-DLSEHIFTDfgGLKFGKISQILFVLLDVSSSLAYCHQKRIIHYDVKPVNILLTTrkignvdv 97 
                  89999999999998877555333447888998887.78888777733334446788888999***************************999999888 PP

                  TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE....EEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBH CS
  Pkinase_Tyr 139 nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk....ftsksDvWsfGvllwEiftlgespypglkneevleklkegkrlekpekcpe 232
                   ++vki+DfG++ ++   ++  ++ e+     +m+pE+lk+ k       + D +sfG++++E+++  +    +++n  ++e+l++++     e + e
   EFC35385.1  98 IDKVKIADFGISVEM--ISTIASSAEHVGTRVYMPPEMLKKVKdikyNYRAFDAYSFGITMFELLSGDKLDNDRVDNFLTIEQLSTKYPGLSYE-IVE 192
                  889*********999..778888888888999*******9998888555677**************888888899*********9999887776.889 PP

                  HHHHHHHHHT-SSGGGS-.-HHHHHHH CS
  Pkinase_Tyr 233 elyelmkkcweedpeeRp.tfselvek 258
                  +l++l ++c  ed  +R  +f+ ++++
   EFC35385.1 193 RLNKLGSSCILEDHLNRCcDFEYIHDE 219
                  999999999999998885368887766 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.2   2.2e-08   9.6e-05     293     389 ..      43     137 ..      16     176 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 2.2e-08
  Pkinase_fungal 293 spvGkpiekaespkellealrDaIkghrsLflkagiLHrDiSenNilitdskke...gerkglLiDLDlakelsddssesgarertGTleFmaie 384
                     +++G    k+++ +++l +l D+   +   + +++i+H D+   Nil+t  k       +k  ++D+ + +e+   s+ +++ e++GT+ +m  e
      EFC35385.1  43 TDFGG--LKFGKISQILFVLLDVSSSLAYCH-QKRIIHYDVKPVNILLTTRKIGnvdVIDKVKIADFGISVEMI--STIASSAEHVGTRVYMPPE 132
                     55554..3899999*****************.*****************6644455567888899999988888..67777789*********** PP

  Pkinase_fungal 385 vlkge 389
                     +lk+ 
      EFC35385.1 133 MLKKV 137
                     99964 PP

>> HSBP1  Heat shock factor binding protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.3      0.02        90      14      30 ..      18      34 ..      15      41 .. 0.85
   2 ?    8.7   0.0   0.00035       1.6      11      34 ..     176     199 ..     168     205 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.02
       HSBP1 14 lqdkFqtmsdqilsriD 30
                + dkF++ s  +++++D
  EFC35385.1 18 ITDKFKKYSLILMEKMD 34
                679*************9 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00035
       HSBP1  11 LqqlqdkFqtmsdqilsriDdMss 34 
                  +ql++k+  +s +i++r++ ++s
  EFC35385.1 176 IEQLSTKYPGLSYEIVERLNKLGS 199
                 47******************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       504  (0.0281109); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1531.50
//
Query:       EFC35386.1  [L=409]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-11   43.6   0.4    8.3e-11   42.1   0.4    1.8  1  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.1   0.4   4.6e-15   8.3e-11       1     102 [.     237     337 ..     237     344 .. 0.84

  Alignments for each domain:
  == domain 1  score: 42.1 bits;  conditional E-value: 4.6e-15
                 HHHHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST...TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT- CS
         BTB   1 lnelresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk...eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqi 96 
                 l++l++ ++ +D+++++g++k +++hk vL+  S++F alf+s+   ++ +++    + +  + e +e++++++Y   +++   e++  lL +a + +i
  EFC35386.1 237 LESLFNDKKTSDIQIKMGEDKYLYCHKTVLSTTSTFFAALFESGssfSDFNNGI-FTPDESEDLELLEIIIKYCYGISFDN---EKISGLLDMAMKHEI 331
                 57899***************************************7443333332.34456677899*********887777...59************* PP

                 HHHHHH CS
         BTB  97 prlkka 102
                 + l++ 
  EFC35386.1 332 KYLVDY 337
                 *99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       693  (0.0386525); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 2445.48
//
Query:       EFC35387.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.4e-08   34.3   0.0    2.2e-08   33.7   0.0    1.3  1  Pkinase_Tyr  Protein tyrosine kinase
    7.7e-06   25.5   0.0    1.4e-05   24.6   0.0    1.4  1  Pkinase      Protein kinase domain
     0.0062   15.6   0.4     0.0086   15.2   0.4    1.1  1  FUSC-like    FUSC-like inner membrane protein yccS


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.7   0.0   3.8e-12   2.2e-08     179     259 .]      10      90 ..       4      90 .. 0.69

  Alignments for each domain:
  == domain 1  score: 33.7 bits;  conditional E-value: 3.8e-12
                  HSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-B....BTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 179 ekkftsksDvWsfGvllwEiftlgespypglkneevleklkegkrlek....pekcpeelyelmkkcweedpeeRptfselvekl 259
                  ++ + ++ Dv+sfGv+++E+f+  ++ +++  ne+++ +l++++ le       +  +e+ ++ ++c+e++p++Rp+f+el+++l
   EFC35387.1  10 KEYLLTALDVYSFGVTMYELFS--QKHIEN--NERLTCFLSTNELLELfpclTLNQANEVIRIGNSCLEYNPKSRPSFAELQKHL 90 
                  55566788**************..444433..33344444444443321111345678999999*****************9986 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.0   2.4e-09   1.4e-05     173     261 ..      11      89 ..       5      91 .. 0.79

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 2.4e-09
                 CB.SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTS CS
     Pkinase 173 ey.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqh 261
                 ey  ++ Dv+s Gv++yel+++k++ +  +++ +    +++l +++  l           +  +e++++ +++l+++pk+R++++el +h
  EFC35387.1  11 EYlLTALDVYSFGVTMYELFSQKHIEN--NERLTCFLSTNELLELFPCL---------TLNQANEVIRIGNSCLEYNPKSRPSFAELQKH 89 
                 454899*************99999988..44444555566655555554.........3356899**********************998 PP

>> FUSC-like  FUSC-like inner membrane protein yccS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.4   1.4e-06    0.0086     173     278 ..      15     120 ..       2     128 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.4e-06
   FUSC-like 173 rllrlyfvaqDihErassshydYe.elreafknsdvlfrfqrllelqakaceeiaqaillnkpyq..hserleraleeleqslellakqnnekekella 268
                   l +y   + ++E +s  h++ + +l+  ++ +++l++f  l+  qa+++ +i+++ l+ +p      ++l++ l +l +++    +++++++++  +
  EFC35387.1  15 TALDVYSFGVTMYELFSQKHIENNeRLTCFLSTNELLELFPCLTLNQANEVIRIGNSCLEYNPKSrpSFAELQKHLLKLTANIL---QNEQKEQPSKKR 110
                 567888888999********987516888889**************************96666552223334444444444333...333333333333 PP

   FUSC-like 269 alrallrnLr 278
                 +l  +l+ ++
  EFC35387.1 111 KLVPTLQTIQ 120
                 3333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1024  (0.0571142); expected 358.6 (0.02)
Passed bias filter:                      539  (0.030063); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1310.22
//
Query:       EFC35388.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       427  (0.0238162); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 2037.69
//
Query:       EFC35389.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        3.5    8.0   7.8        6.6    7.2   5.8    2.4  3  GFA       Glutathione-dependent formaldehyde-activating enzym


Domain annotation for each model (and alignments):
>> GFA  Glutathione-dependent formaldehyde-activating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   5.8   0.00037       6.6      38      61 ..      17      42 ..       3      61 .. 0.76
   2 ?   -0.9   0.8      0.12   2.2e+03      49      59 ..      48      58 ..      43      71 .. 0.80
   3 ?   -2.6   0.0      0.41   7.3e+03       6      74 ..     234     250 ..     230     271 .. 0.53

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00037
         GFA 38 kkt..adsgnkvtrsfCpeCgsplys 61
                ++    +s+++v+r+fC +C ++l+ 
  EFC35389.1 17 EQVyfIQSNQHVDRYFCIHCYCELFP 42
                33333789***************994 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.12
         GFA 49 rsfCpeCgspl 59
                ++ C++C+s  
  EFC35389.1 48 TYCCEDCMSDT 58
                68899999875 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.41
         GFA   6 sdCrkasgsaftanavvkaealellegelkeykktadsgnkvtrsfCpeCgsplyseesaapevvivrv 74 
                 ++C++                                                     + a+++++v  
  EFC35389.1 234 KECKHE----------------------------------------------------EDASHFLVVDE 250
                 444444....................................................33334444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1822.25
//
Query:       EFC35390.1  [L=199]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-41  140.4   0.1    6.6e-41  139.6   0.1    1.4  1  Ras       Ras family
    1.7e-15   57.3   0.1    5.2e-15   55.7   0.1    1.8  1  Roc       Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.056   13.9   0.1       0.13   12.8   0.1    1.6  1  DUF4497   Protein of unknown function (DUF4497)


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.6   0.1   1.1e-44   6.6e-41       1     161 [.      10     164 ..      10     165 .. 0.97

  Alignments for each domain:
  == domain 1  score: 139.6 bits;  conditional E-value: 1.1e-44
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++++Gd+ vG  slllr+ +++F+++y s +gvdf++++ie+dgk++kl+iw         + ++ y++da+g+++ y+it+++sf+nv++w++e+ +
  EFC35390.1  10 KILFLGDRKVGTKSLLLRYSDNTFSDTYYSALGVDFKIRTIEMDGKTLKLQIWNAI------ENHPGYFKDAHGVFIAYSITDQSSFDNVSQWINEVDK 102
                 899**************************************************864......44799******************************** PP

                 HSTTTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHHHHHHHHHHHH CS
         Ras 100 vaeenvpivLvGnKvDleekravsteegeelakelglkfletSAktnenveeafeellreil 161
                  a+ +++  LvG K+Dl+ +r+++++ege+la++++++f+etSAk++ nveeaf +++ ei+
  EFC35390.1 103 AAPVDITKFLVGCKSDLTAERVIERSEGEQLANRYDMPFIETSAKSSANVEEAFIRMVLEIK 164
                 ***99**************************************************9998876 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.7   0.1   8.8e-19   5.2e-15       1     119 [.      10     118 ..      10     119 .. 0.86

  Alignments for each domain:
  == domain 1  score: 55.7 bits;  conditional E-value: 8.8e-19
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K++++Gd +vG  sll r+ +++fs+++ s +gvdf+ +++ +++        k++kl+iW         + hp y+++a+ +++ y    ++s++n++
  EFC35390.1  10 KILFLGDRKVGTKSLLLRYSDNTFSDTYYSALGVDFKIRTI-EMD-------GKTLKLQIWNA------IENHPGYFKDAHGVFIAYSitdQSSFDNVS 94 
                 9***********************************88765.333.......46899****74......5679********999988644377889*** PP

                 HHHHHHHHHCS.SS-EEEEEE-TT CS
         Roc  97 eWlkelkkvag.kspvilvgnkiD 119
                 +W++e++k a+ ++  +lvg k D
  EFC35390.1  95 QWINEVDKAAPvDITKFLVGCKSD 118
                 **********9445779*****99 PP

>> DUF4497  Protein of unknown function (DUF4497)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   2.1e-05      0.13      46      90 ..     147     191 ..     135     194 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.1e-05
     DUF4497  46 saeislselfnklikevkekkknepvsktikgtfpLkdedgqtvG 90 
                 + +  ++e+f +++ e+k++ +n+p+++t+++t +L+d++ ++ G
  EFC35390.1 147 KSSANVEEAFIRMVLEIKKNLDNKPKAATVTSTTKLSDKKAKKEG 191
                 6778899*******************************9988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (199 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       813  (0.0453455); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1267.37
//
Query:       EFC35391.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.027   13.4   7.1      0.029   13.3   7.1    1.1  1  PA26            PA26 p53-induced protein (sestrin)
       0.16   12.4   1.2       0.58   10.6   0.0    2.3  2  GCK             GCK domain
       0.22   11.6   8.6       0.25   11.3   8.6    1.0  1  Neur_chan_memb  Neurotransmitter-gated ion-channel transmembr
       0.49   10.5   7.0       0.69   10.0   7.0    1.3  1  RP-C_C          Replication protein C C-terminal region
       0.59    9.5   6.0       0.64    9.4   6.0    1.1  1  Endostatin      Collagenase NC10 and Endostatin
       0.61    9.1   9.5       0.74    8.8   9.5    1.0  1  SLC12           Solute carrier family 12
       0.87    7.6  11.3          1    7.4  11.3    1.0  1  Hid1            High-temperature-induced dauer-formation prot
          1    9.4   9.1        1.2    9.2   9.1    1.0  1  PARM            PARM
        1.1    8.9  10.3        1.4    8.6  10.3    1.1  1  SAGA-Tad1       Transcriptional regulator of RNA polII, SAGA,
        2.8    8.0  12.7        3.3    7.7  12.7    1.1  1  Asp-B-Hydro_N   Aspartyl beta-hydroxylase N-terminal region
        3.8    7.2  16.0        6.7    6.4  16.0    1.3  1  Use1            Membrane fusion protein Use1
        3.9    6.2  10.8        4.1    6.1  10.8    1.1  1  Presenilin      Presenilin
        4.2    7.4  12.9        5.1    7.2  12.9    1.1  1  TP53IP5         Cellular tumour antigen p53-inducible 5
        7.3    6.0   9.0        9.9    5.6   9.0    1.4  1  Sec62           Translocation protein Sec62


Domain annotation for each model (and alignments):
>> PA26  PA26 p53-induced protein (sestrin)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   7.1   2.2e-05     0.029     193     263 ..      46     139 ..      18     160 .. 0.58

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.2e-05
        PA26 193 s..............anekedsseeeeeelerkaaaeaeaevealmermkklqeeedeeeeaseeelserfekeeseslllaaa.........d 263
                 +              ++ +++ ++ee ++ ++++++ +++  e l++rmk+++ee++++  +++e+++e+   e s s+ +a++         +
  EFC35391.1  46 RieinladllgiptsNEAQQQPKKEEPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKQEEKPIETSPSAAVASQpkgeesiqqQ 139
                 233445555555543234444555555556666677778888***************9887777777777755555555555543344322221 PP

>> GCK  GCK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00045      0.58       8      25 ..       8      25 ..       5      45 .. 0.80
   2 ?   -0.7   0.8       1.6     2e+03      60      70 ..      90     100 ..      60     116 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00045
         GCK  8 FmkgGgCkesfiawekcv 25
                F+k+ +Ck++f+ +ek +
  EFC35391.1  8 FIKDPDCKDAFMGLEKLI 25
                9*************9976 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.6
         GCK  60 iLaaekaaeee 70 
                 +L+ +k+++ee
  EFC35391.1  90 LLQRMKEMREE 100
                 44555555544 PP

>> Neur_chan_memb  Neurotransmitter-gated ion-channel transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   8.6    0.0002      0.25      84     198 ..      33     150 ..      18     160 .. 0.50

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.0002
                     H-S-S---HHHHHHHTTHHHHHHC--------------.--------------------------------------SS---TTGGG--...... CS
  Neur_chan_memb  84 rsprthtmpawvrkvfldklprllfmkrpsevkdnekklssgasseaeelilskskseskkaklseeqgsekastckckckegeeaspstqlsk. 177
                         t +++++vr++ ++   +ll++ + +e+++++kk+ + +++++e +++ +s  e+  ++++e  +++k++++++++k++ee+  +t+ s+ 
      EFC35391.1  33 DISATAQTKPKVRRIEINLA-DLLGIPTSNEAQQQPKKE-EPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKQEEKPIETSPSAa 125
                     35678999999999999955.566666655555555543.2222233333333333333333444444333333333333333333222222222 PP

                     ....-----TTTTTHHHHHHHHHHH CS
  Neur_chan_memb 178 ....eelspelkkavegvkyiadhl 198
                          + ++++++ v++ + +a+++
      EFC35391.1 126 vasqPKGEESIQQQVKEQEIVAENT 150
                     2333666667777777777777665 PP

>> RP-C_C  Replication protein C C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   7.0   0.00054      0.69      23     118 ..      38     157 ..      14     161 .] 0.56

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00054
      RP-C_C  23 aeleelleelealreevenalesalkaenssanesqnerhiqnsnpdssse......sepasekereekeaaaasaeaepsek................ 99 
                 a+ ++ ++++e   +++  +  s++ +++ +++e ++e++ ++s+p+s +e      +    e ++e+k + ++++e++++ek                
  EFC35391.1  38 AQTKPKVRRIEINLADLLGIPTSNEAQQQPKKEEPKKEKKETTSTPQSFRElllqrmK----EMREEQKSQPSQTQEKKQEEKpietspsaavasqpkg 132
                 3444445555555555555557777777777788888888888888777774433321....1111222222222222222223344555566666677 PP

      RP-C_C 100 ......ksvplglvlkacPeiadYa 118
                       +  + ++v + +P+++ Y 
  EFC35391.1 133 eesiqqQVKEQEIVAENTPNMTRYK 157
                 7667644446677888888888885 PP

>> Endostatin  Collagenase NC10 and Endostatin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.0    0.0005      0.64      70     155 ..      58     152 ..       8     160 .. 0.48

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0005
  Endostatin  70 Pvvksskerlvllearrktksskesvkake........keaskeeleekae.kkveesekslttarraskkepeaaaetsesgpaLhLvAlnepl 155
                 P+ ++ +++ +++e ++++k ++++ ++          +++++++++++++ +k++e+++ +t+++ a +++p+   + +++ ++ ++vA n+p 
  EFC35391.1  58 PTSNEAQQQPKKEEPKKEKKETTSTPQSFRelllqrmkEMREEQKSQPSQTqEKKQEEKPIETSPSAAVASQPKGEESIQQQVKEQEIVAENTPN 152
                 33333333222221111111111111111112222221222222222222213333333344444444455566666666777778899999986 PP

>> SLC12  Solute carrier family 12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   9.5   0.00058      0.74     116     233 ..      24     139 ..      13     160 .. 0.35

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00058
       SLC12 116 aiLrlkegldvsellqeeeeeeeekekkeaeese.....keeeekkkakkkklleekskekeekekleekdsnlslseekkeeekekkkekkkkkek.. 207
                 +i+r+ +  d+s + q++ + ++ + +  a   +     +++e++++ k    +ee +kek+e++++ ++  +l l+++k+++e++k+++++++++k  
  EFC35391.1  24 LIFRVVHNADISATAQTKPKVRRIEINL-A---DllgipTSNEAQQQPK----KEEPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKqe 114
                 6999999999996666664444322221.1...1223332222222221....2222222222222222222333333333222222222222221100 PP

       SLC12 208 keklkkkekslllkeaskeekevlee 233
                 ++  +++ ++ + +++++ee +++++
  EFC35391.1 115 EKPIETSPSAAVASQPKGEE-SIQQQ 139
                 11122222222222222222.22221 PP

>> Hid1  High-temperature-induced dauer-formation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4  11.3    0.0008         1     552     677 ..      19     148 ..      14     160 .. 0.54

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0008
        Hid1 552 kgnrnLvYsilrkrkvfealrnltlesaseeiersne....sarldsideeeeenssessrieesrsesrspslsevpelksslaitddeskaereksa 646
                  g ++L++ ++ ++++  a+++++ + + +ei+   +    +++ ++ + ++ee ++e++++ ++ ++ r+  l++ +e+ ++ + ++++++++++ ++
  EFC35391.1  19 MGLEKLIFRVVHNADI-SATAQTKPKVRRIEINLADLlgipTSNEAQQQPKKEEPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKQ-EE 115
                 5567899999988774.7888888899999999988888884455555555566666666666666666777677777766666666655554433.33 PP

        Hid1 647 tessssqavs..qlremsekarakesaestees 677
                 +++++s+++    + + +e+ +++ ++++   +
  EFC35391.1 116 KPIETSPSAAvaSQPKGEESIQQQVKEQEIVAE 148
                 333333322211111122222222222222222 PP

>> PARM  PARM
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   9.1   0.00095       1.2      55     172 ..      35     157 ..      28     161 .] 0.75

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00095
        PARM  55 tasaetstlpknvsvepre..eeatspaskwegtetdpssvklsstssgveltptpeehssgtpe..asvpa.tgsqspaesptltSpqapasspssls 148
                 +a+a+t ++ + + ++  +    +ts+  +++ ++++p + k  +ts  + +     ++ ++  e   s p+ t+ +++ e+p+ tSp a+++s++   
  EFC35391.1  35 SATAQTKPKVRRIEINLADllGIPTSNEAQQQPKKEEPKKEKKETTSTPQSFRELLLQRMKEMREeqKSQPSqTQEKKQEEKPIETSPSAAVASQPKGE 133
                 455666666666666655411457899999998999999999999999999999987777776665555555144455899**********99999999 PP

        PARM 149 tslppevssasvstnhssaetstk 172
                  s+  +v   +++++++  +t  k
  EFC35391.1 134 ESIQQQVKEQEIVAENTPNMTRYK 157
                 9999****9999999988887665 PP

>> SAGA-Tad1  Transcriptional regulator of RNA polII, SAGA, subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  10.3    0.0011       1.4      63     168 ..      24     143 ..      23     158 .. 0.53

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0011
   SAGA-Tad1  63 LllsIlkNalrespdclaktppsatakkkks...............slkkspkksrsgdsqeerlkkrvmslpprdrkrlkaitkeag....vlaee.. 140
                 L+  +++Na  +     a+t+p++                        +++pkk++ ++++ +++++ ++s+ +   +r+k++ +e++           
  EFC35391.1  24 LIFRVVHNADIS---ATAQTKPKVR-----RieinladllgiptsnEAQQQPKKEEPKKEK-KETTSTPQSFRELLLQRMKEMREEQKsqpsQ---Tqe 110
                 778888888222...2333333332.....1223446666666664334444444444444.4667777788888888888887777744321...133 PP

   SAGA-Tad1 141 ........sskpkisvvseeetekrekennskewsq 168
                         +++p++ v+s++++e++++++ ++   q
  EFC35391.1 111 kkqeekpiETSPSAAVASQPKGEESIQQQVKE---Q 143
                 33444555555555666666666666655444...3 PP

>> Asp-B-Hydro_N  Aspartyl beta-hydroxylase N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7  12.7    0.0026       3.3     142     230 ..      59     149 ..      26     160 .. 0.62

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0026
  Asp-B-Hydro_N 142 dsderqeeleagkvkeevEeslkveetvseeakkdmkekaseeenekskepve.eaekekae..akeveeedkeeeaeedekveeskaieee 230
                    +s+e+q++ + ++ k+e  e+    +  +e   + mke+ +e+++++s+   + ++ek+ ++  +  v+++ k ee   +++v e++++ e+
     EFC35391.1  59 TSNEAQQQPKKEEPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKkQEEKPIETspSAAVASQPKGEE-SIQQQVKEQEIVAEN 149
                    4455555555555555556677778888888888899999998888877666623334333311345666666555.345555555555554 PP

>> Use1  Membrane fusion protein Use1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4  16.0    0.0052       6.7      83     173 ..      63     155 ..      33     157 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0052
        Use1  83 nqllapgeeskeekeeskereeaskelrqkekakyqkelrkellgkndsssspekekeskkk...ksdedldavlkkhenlqEklaeemlsLar 173
                  q+ ++ ee k+ek+e++++ ++ +el +++ +++++e++++  ++++++++++   e++++    s+ + ++ ++++ + qE +ae+  +++r
  EFC35391.1  63 AQQQPKKEEPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKQEEK-PIETSPSaavASQPKGEESIQQQVKEQEIVAENTPNMTR 155
                 233333345666677777778888****************99999988665544.444444468899999999999999999999999999998 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1  10.8    0.0032       4.1     236     316 ..      61     141 ..      23     157 .. 0.45

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0032
  Presenilin 236 eeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaeesseekeseessesseeeeeeeeeeeese 316
                 +e++++ kk+e ++e+++++++ +++ e   q+ ++ +e+++++ ++++++++++++ e+++s   +++ + ee+ +++++
  EFC35391.1  61 NEAQQQPKKEEPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKQEEKPIETSPSAAVASQPKGEESIQQQVK 141
                 222222222222222222222222222222222222222222222222222222222233333333333333333333322 PP

>> TP53IP5  Cellular tumour antigen p53-inducible 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2  12.9     0.004       5.1      73     161 ..      64     151 ..      33     160 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.004
     TP53IP5  73 lqearalekkleskklestkepkelkskewkeeskvrnkakgspaavpkkeeqaeaevpktsrgeglntkaq.kkqlatkkprvvllkty 161
                     + ++++++++k e+t  p+ +++   +  +++r+++k++p+ +++k+++ ++    +s+   +++k++ + q+++k++++v  +t 
  EFC35391.1  64 Q--QQPKKEEPKKEKKETTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKQEEKPIETSPSAAVASQPKGEeSIQQQVKEQEIVAENTP 151
                 2..35778888999999999999998877899999****999999999999888888888888877776665266888888888776665 PP

>> Sec62  Translocation protein Sec62
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   9.0    0.0077       9.9      25      78 ..      64     116 ..      40     159 .. 0.50

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0077
       Sec62  25 kkkkeklkevkkkekaekvfkelkksqlalrveklkekekkkkkeekkkkkkkk 78 
                 +++++k++++k+k++ ++ + ++ ++ l  r+++++e++k++ +++++kk+++k
  EFC35391.1  64 QQQPKKEEPKKEKKE-TTSTPQSFRELLLQRMKEMREEQKSQPSQTQEKKQEEK 116
                 122222222222222.22222222223333333333333333322222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2803  (0.156339); expected 358.6 (0.02)
Passed bias filter:                      794  (0.0442858); expected 358.6 (0.02)
Passed Vit filter:                       131  (0.0073066); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 1011.77
//
Query:       EFC35392.1  [L=695]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (695 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       793  (0.04423); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.47
# Mc/sec: 4470.02
//
Query:       EFC35393.1  [L=278]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      6e-18   65.2   3.9    7.9e-18   64.8   3.9    1.1  1  Pkinase         Protein kinase domain
    2.8e-08   33.4   0.6    4.1e-08   32.8   0.6    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
    6.9e-05   21.8   0.7     0.0034   16.2   0.1    2.0  2  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.8   3.9   1.3e-21   7.9e-18      14     164 ..     124     278 .]     121     278 .] 0.79

  Alignments for each domain:
  == domain 1  score: 64.8 bits;  conditional E-value: 1.3e-21
                 EEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH...HHSS--HHHHHHHHHHHH CS
     Pkinase  14 kVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlle...rkgslseeeakkiakqil 108
                 kVyk++    g+  +vKk+  + +         +E +il+kl+ h   v l++  +++++++l l +++    + +++   +++  +  ++  ++ + +
  EFC35393.1 124 KVYKGK---IGDNNVVKKVFSDVKIG------EHEYEILQKLNsHHGTVDLVHKEQTSESFHLYLKLMDFSLENCRITefgNNSFGKLYQLLMVFVKCA 213
                 555555...44444555555444443......259**********************************775444555675555566779999****** PP

                 HHHHHHHHTTEE-SS-SGGGEEEET.TTE........EEE-SGTTSEESSSSCS.BCTTTSCGGGS CS
     Pkinase 109 egleylHskgiiHrDlKpeNiLide.kge........lKitDFGlakelesssk.ltsfvgtseYl 164
                 + l+y+H+++iiH D+Kp+NiLid  + +        +Ki+DF +++++++ ++ + +  gts+Y+
  EFC35393.1 214 NTLNYMHKEKIIHYDIKPSNILIDMvD-VnglqlvgdVKIADFNVSEQVDNYQStTATASGTSHYM 278
                 ************************633.235666677*************9888788999*****8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.8   0.6   6.9e-12   4.1e-08      50     161 ..     148     269 ..     109     278 .] 0.78

  Alignments for each domain:
  == domain 1  score: 32.8 bits;  conditional E-value: 6.9e-12
                  HHHHHHHTS.-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT.CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE....... CS
  Pkinase_Tyr  50 eeakimkkl.khpnivkllgvctkeepllivteyvkgGdLlkfLrkk.ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse....... 138
                  +e++i++kl +h+  v l+     +e+  + +++++    +  +++  +++  +l +ll + ++ A+ ++y++++k++H d+   N+L++        
   EFC35393.1 148 HEYEILQKLnSHHGTVDLVHKEQTSESFHLYLKLMDFSLENCRITEFgNNSFGKLYQLLMVFVKCANTLNYMHKEKIIHYDIKPSNILIDMvdvnglq 245
                  5788888888888888888888877777777777766432333333333445678999********************************99999998 PP

                  .TTEEEE-STTTHEETTTSSEEEE CS
  Pkinase_Tyr 139 .nkvvkisDfGLardiekddeyvk 161
                      vki+Df +++++ + +++++
   EFC35393.1 246 lVGDVKIADFNVSEQVDNYQSTTA 269
                  8789************33333332 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.0    0.0023        14     159     213 ..     124     173 ..     106     190 .. 0.78
   2 !   16.2   0.1   5.7e-07    0.0034     302     381 ..     199     278 .]     190     278 .] 0.78

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0023
  Pkinase_fungal 159 tcwrarkegergkeyvvKdsWrdaerk.sEaelLkkaeergvegvarlvahedvee 213
                      +++++       + vvK +  d + + +E e+L+k   ++ +g + lv++e+  e
      EFC35393.1 124 KVYKGKIG----DNNVVKKVFSDVKIGeHEYEILQKL--NSHHGTVDLVHKEQTSE 173
                     45555554....4569999999999888*********..88999999999998654 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 5.7e-07
  Pkinase_fungal 302 aespkellealrDaIkghrsLflkagiLHrDiSenNilitdskke...gerkglLiDLDlakelsddssesgarertGTleFm 381
                     +++  +ll ++  + ++++ ++ k +i+H Di   Nili   + +         ++D+++  +++  + +s   +  GT  +m
      EFC35393.1 199 FGKLYQLLMVFVKCANTLNYMH-KEKIIHYDIKPSNILIDMVDVNglqLVGDVKIADFNVSEQVD--NYQSTTATASGTSHYM 278
                     77889*****************.***************985555533323345577777777777..5566667888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (278 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       462  (0.0257683); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1738.42
//
Query:       EFC35394.1  [L=358]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   15.3   0.1      0.034   14.0   0.1    1.7  1  UPF0167   Uncharacterised protein family (UPF0167)
      0.057   13.4   0.4       0.16   12.0   0.4    1.7  1  LOH1CR12  Tumour suppressor protein


Domain annotation for each model (and alignments):
>> UPF0167  Uncharacterised protein family (UPF0167)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.1   3.8e-06     0.034      20      79 ..      13      72 ..       4      90 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.8e-06
     UPF0167 20 eekCqcCgkereliyespfysvedvealCpwCiadGsaakkfegefqddasl.veeeldee 79
                +  C+c +k++  +  ++f s ++v +l  +Ci++ ++  k +g +++d +  ++ e  ++
  EFC35394.1 13 SDFCDCLNKNNVNLGGGQFVSANQVLNLANKCISEETINFKVDGAVSNDIKRwID-EAISS 72
                567********************************************99876455.33333 PP

>> LOH1CR12  Tumour suppressor protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.4   1.7e-05      0.16      59     111 ..     231     283 ..     222     291 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.7e-05
    LOH1CR12  59 kevdakiitllaelrekqkqyasyaealskvnelsdqlsriqiiledivpllE 111
                 k+ ++k + +la+  +++k+ + +     +v +ls+ ++++ + +e+i+  + 
  EFC35394.1 231 KTTSKKKSMILAKEDDRKKTVDRFKSLTDQVTSLSNTITSLSSTIEKIISHMK 283
                 677788888999*************************************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1090  (0.0607954); expected 358.6 (0.02)
Passed bias filter:                      690  (0.0384851); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2414.82
//
Query:       EFC35395.1  [L=370]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.019   15.1   0.4      0.044   14.0   0.3    1.7  1  DUF3853      Protein of unknown function (DUF3853)
      0.086   12.7   0.9       0.24   11.3   0.2    2.0  3  Tox-MPTase3  Metallopeptidase toxin 3


Domain annotation for each model (and alignments):
>> DUF3853  Protein of unknown function (DUF3853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.3   4.9e-06     0.044       2      34 ..      24      57 ..      23      75 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 4.9e-06
     DUF3853  2 leeLLekPvlkmtGeellfLlkka.etkeeaktp 34
                +++LL+kP+ k+t  el++L k+   ++e++k++
  EFC35395.1 24 IKKLLQKPLHKLTNLELVVLCKHYkFESEKVKQA 57
                899********************93344444433 PP

>> Tox-MPTase3  Metallopeptidase toxin 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.2   2.6e-05      0.24      22      94 ..      51     123 ..      40     130 .. 0.91
   2 ?   -3.7   0.0       1.1     1e+04      19      36 ..     139     157 ..     136     160 .. 0.78
   3 ?   -2.3   0.0      0.43   3.8e+03      44      83 ..     304     354 ..     300     363 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.6e-05
  Tox-MPTase3  22 kpevvkayaKlgglnesklkdalaWGkgplikieskllvkayGlttpddkgeeiliagklvekfekgkekelv 94 
                  +++v +a+ K ++ n ++  + ++     +i++e++ l++   ++++d++  + ++ + +++kfe +++  ++
   EFC35395.1  51 SEKVKQALEKNAKFNGADYDKLCKMKTKEEIEVEKERLIDVVNKYVNDEGESKFFVYQVVIAKFEDERKLFFM 123
                  678999***********************************************************99876555 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.1
  Tox-MPTase3  19 l.lkkpevvkayaKlggln 36 
                  +  ++p   + + Kl++++
   EFC35395.1 139 VhSNNPTTTSTFLKLCNNS 157
                  5567888999999999986 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 0.43
  Tox-MPTase3  44 laWGkgpliki..........eskllvkayGlttpddkgeei.liagklve 83 
                  ++W + +l+++          +++      G++ + d++++  ++ +k+  
   EFC35395.1 304 IEWNDNSLVRVecdsdqkldaNNTIAAIDIGEIAGADNVKKAfELITKISC 354
                  567777777777777666665555555566777777777665455555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1068  (0.0595683); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2292.40
//
Query:       EFC35396.1  [L=159]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       487  (0.0271627); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1075.22
//
Query:       EFC35397.1  [L=164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0037   16.6   0.0      0.005   16.2   0.0    1.1  1  Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase famil


Domain annotation for each model (and alignments):
>> Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   2.8e-07     0.005       1      35 [.      11      53 ..      11      59 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 2.8e-07
                  CCCS-EEET........TEEESSSEEE----S-TTTTTCS.HH CS
  Oxidored_FMN  1 kLFkPikig........nmtLknRivmapmtrlraldkgnvle 35
                  kLF+P+++g          tL +Rivmap+tr ra d +   +
    EFC35397.1 11 KLFTPLTLGtdkipatqRITLSHRIVMAPLTRCRAVDGDCEQT 53
                  689999998333333323589**************99885544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       353  (0.0196888); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.24s 00:00:00.64 Elapsed: 00:00:00.40
# Mc/sec: 1217.75
//
Query:       EFC35398.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.2e-05   23.4   0.0    6.6e-05   22.8   0.0    1.2  1  Phage_integrase  Phage integrase family


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   3.7e-09   6.6e-05      35     169 ..      10     155 ..       2     157 .. 0.83

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 3.7e-09
                      --HHHHTT-BGGG.EECTTTEEEEE...........EEECSSSSEEEEECT...HHHHHHHHHHHHHHCHCCTTTSBSSBETTSSB--HHHHHH CS
  Phage_integrase  35 lRisEllsLrvkd.ldlengvilvh...........eregKgskeravpls...eealellkellskaleeaeksellfaskrgkplsrqtvrk 113
                      +R +El++L+++   +l+ng i+++           e+ ++  k    +l       ++ll +++++    ++ ++ lf  +++   ++++v++
       EFC35398.1  10 ARPGELARLKWGYvTKLRNGNIKLDlsghktdffllEKPITIDK----HLEnpsVCPVKLLFDYMNTVQHFKKADSPLFSLQDNIFFNTEDVSQ 99 
                      6999********97789999999984444444444333333333....3333335678999999999999999999****************** PP

                      HHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHHHHT-SSCCHHHHHHCC CS
  Phage_integrase 114 afkraveeagiekpltpHtlRhsfataLleagvdlrvvqkllGHssisttqiYthv 169
                       +k+a    + e  +++H+lR  + t+ + +g++++ + +   H+++++ q Y + 
       EFC35398.1 100 LIKNAMFSVDSEITVSGHSLRIGATTESIIKGIPTQDIIMGTRHKDVKSLQPYQRQ 155
                      ********999999*************************************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       330  (0.0184059); expected 358.6 (0.02)
Passed bias filter:                      285  (0.015896); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.26s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 1275.12
//
Query:       EFC35399.1  [L=330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1103  (0.0615204); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1912.00
//
Query:       EFC35400.1  [L=608]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.045   14.2   0.3       0.62   10.5   0.0    2.8  3  Ntox35     Bacterial toxin 35


Domain annotation for each model (and alignments):
>> Ntox35  Bacterial toxin 35
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.11     2e+03      39      68 ..      66      99 ..      64     101 .. 0.74
   2 ?   10.5   0.0   3.5e-05      0.62      22      73 ..     252     303 ..     247     307 .. 0.91
   3 ?   -1.7   0.1      0.24   4.2e+03      21      33 ..     404     416 ..     399     427 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.11
      Ntox35 39 gkeeaiksakqk....vtkikGkeievtaiakdG 68
                 kee++k  +++    ++ ik+ ++ v++    G
  EFC35400.1 66 DKEEKFKPSNRAtdgiEYFIKNSSVHVKFLTYSG 99
                56777776666666668999*******9987666 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 3.5e-05
      Ntox35  22 knnwkdvkkivvkvmkegkeeaiksakqkvtkikGkeievtaiakdGkvkis 73 
                 ++  k+v ++v k m +  + + k++k    +i ++ i ++++ k+G+ k +
  EFC35400.1 252 ERMTKYVIELVYKSMASFASYPKKGNKYYIPEIANQFISGKCFLKNGEYKFI 303
                 455799*****************************************99876 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.24
      Ntox35  21 kknnwkdvkkivv 33 
                 +k+ wk+v+++v 
  EFC35400.1 404 GKRVWKNVQNLVP 416
                 5666999998774 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (608 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      541  (0.0301746); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.47
# Mc/sec: 3872.45
//
Query:       EFC35401.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00051   19.9   0.6    0.00087   19.1   0.6    1.3  1  ASFV_J13L    African swine fever virus J13L protein
  ------ inclusion threshold ------
      0.022   14.7   0.3      0.045   13.6   0.3    1.4  1  TMEM154      TMEM154 protein family
      0.053   13.6   3.6       0.11   12.6   3.6    1.5  1  Insulin_TMD  Insulin receptor trans-membrane segment
       0.19   11.2   0.7       0.27   10.8   0.7    1.1  1  DUF5385      Family of unknown function (DUF5385)
       0.34   10.4   7.8       0.76    9.2   7.8    1.6  1  SKG6         Transmembrane alpha-helix domain


Domain annotation for each model (and alignments):
>> ASFV_J13L  African swine fever virus J13L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.6   2.4e-07   0.00087      34      75 ..     174     213 ..     156     220 .. 0.76

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 2.4e-07
   ASFV_J13L  34 iliaivvliiiiivliylfssrkkkaaaaieeediqfinpyq 75 
                 ++i iv +ii+++v iyl+  rk+k  + +e++d++++n  +
  EFC35401.1 174 LIIPIVCIIIVLLVAIYLL--RKRKIKTNLENNDVDIVNVRE 213
                 4567888888888999998..666666789999999999655 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.3   1.3e-05     0.045      54     105 ..     166     210 ..     154     218 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.3e-05
     TMEM154  54 dqlelvlmiiiPlvllillllvviiliqkkkrkrsKddekseaesdeldsen 105
                 d  +l  ++iiP v +i++llv i l    +++++K +     e++++d  n
  EFC35401.1 166 DLFALFALLIIPIVCIIIVLLVAIYLL---RKRKIKTN----LENNDVDIVN 210
                 5556677899**999999988888888...66666665....4444555555 PP

>> Insulin_TMD  Insulin receptor trans-membrane segment
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   3.6   3.1e-05      0.11       6      42 ..     162     195 ..     160     198 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.1e-05
  Insulin_TMD   6 adyldpsnivkIvigPviciillllvigavfvvvkKr 42 
                   + +d   + +  i P++cii++llv+   + +++Kr
   EFC35401.1 162 RNNYDLFALFALLIIPIVCIIIVLLVAI--Y-LLRKR 195
                  5666667788899***********9865..3.56666 PP

>> DUF5385  Family of unknown function (DUF5385)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.7   7.4e-05      0.27       7      39 ..     175     208 ..     169     216 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 7.4e-05
     DUF5385   7 ii.liiiiiiilvivfllrkkkkqkeeekaggki 39 
                 ii ++ iii+ lv ++llrk+k + + e++   i
  EFC35401.1 175 IIpIVCIIIVLLVAIYLLRKRKIKTNLENNDVDI 208
                 3313446666688899999999888877777665 PP

>> SKG6  Transmembrane alpha-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   7.8   0.00021      0.76      18      38 .]     176     196 ..     175     196 .. 0.97

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00021
        SKG6  18 VPVaViiivLlailifvrRRk 38 
                 +P++ iiivLl+  ++ r+Rk
  EFC35401.1 176 IPIVCIIIVLLVAIYLLRKRK 196
                 9*******************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       960  (0.0535445); expected 358.6 (0.02)
Passed bias filter:                      618  (0.0344693); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1299.81
//
Query:       EFC35402.1  [L=230]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      1e-07   32.5   0.1      2e-07   31.6   0.1    1.5  1  MJ1316       MJ1316 RNA cyclic group end recognition domain
  ------ inclusion threshold ------
      0.029   14.3   0.7          3    7.9   0.0    2.9  3  Turandot     Stress-inducible humoral factor Turandot
       0.14   12.0   0.4       0.25   11.2   0.4    1.4  1  KdpC         K+-transporting ATPase, c chain


Domain annotation for each model (and alignments):
>> MJ1316  MJ1316 RNA cyclic group end recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.6   0.1   3.3e-11     2e-07       3      76 .]      72     140 ..      70     140 .. 0.82

  Alignments for each domain:
  == domain 1  score: 31.6 bits;  conditional E-value: 3.3e-11
      MJ1316   3 taqdvlnRirWdkeld..kskfvvgyldRfkgikevpleeiswiedflleeeegelaIPlHRiryikrk.gevvWdR 76 
                 t ++v++R+ Wd++l   +++    y dRf+g   ++ +e+   e     +e+     P+HRi+   ++ ++v Wd+
  EFC35402.1  72 TCKEVIDRLNWDESLAdvMQNLAMIYKDRFEGDVFISYSEYENSEL----KED----LPQHRIQSLIYRdEHVFWDK 140
                 889***********9834589999***************8888444....444....9******9777637777886 PP

>> Turandot  Stress-inducible humoral factor Turandot
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.0   0.00051         3      10      49 ..      38      77 ..      33      79 .. 0.86
   2 ?   -1.5   0.0      0.42   2.5e+03       7      21 ..      86     100 ..      83     130 .. 0.67
   3 ?    3.5   0.1     0.012        69      25      44 ..     204     223 ..     194     227 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00051
    Turandot 10 niqeliaiYekyssslqlspderekldrlireyke.eevlv 49
                + +++++ Y+k s s +ls++e+e +++  +++++ +e ++
  EFC35402.1 38 SSPSMMEYYKKSSGSSPLSKEEEELMNQKKERFQTcKE-VI 77
                5688999************************9999655.45 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.42
    Turandot   7 kikniqeliaiYeky 21 
                 + + +q+l+ iY++ 
  EFC35402.1  86 LADVMQNLAMIYKDR 100
                 556677888888764 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.012
    Turandot  25 lqlspderekldrlireyke 44 
                  +l++de++++d+ i ey e
  EFC35402.1 204 ENLEDDEEDEIDQYIAEYDE 223
                 4799**************86 PP

>> KdpC  K+-transporting ATPase, c chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.4   4.2e-05      0.25      57     101 ..      31      75 ..      10      92 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4.2e-05
                 --SSS--------ST-TTT-------SS-HHHHHHHHHHHHHHHH CS
        KdpC  57 tsdkYfhgRpsavnynaaasggsnlgpsnpellerveervaalra 101
                 +s+ ++ + ps ++y   +sg+s l+++++el+++ +er +++++
  EFC35402.1  31 SSPSHLSSSPSMMEYYKKSSGSSPLSKEEEELMNQKKERFQTCKE 75 
                 46889**********************************998874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (230 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1523  (0.0849462); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1399.06
//
Query:       EFC35403.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-10   41.0   2.0    4.7e-10   39.7   0.6    2.1  2  BTB       BTB/POZ domain
    4.9e-05   23.4   0.9    0.00072   19.6   0.9    2.6  1  BACK      BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.7   0.6   5.2e-14   4.7e-10      22     109 ..      95     185 ..      83     187 .. 0.83
   2 ?   -0.2   0.0      0.13   1.2e+03      28      53 ..     204     228 ..     201     267 .. 0.75

  Alignments for each domain:
  == domain 1  score: 39.7 bits;  conditional E-value: 5.2e-14
                 EEEE-HHHHHHH-HHHHHHHTST.TTTTCCCEEEEETTSGHHHHHH.HHHHHHHSEE.EC-CGGGHHHHHHHHHHHT-HHHHHHHHHHHHH CS
         BTB  22 efkahkavLaarSpyFkalftsk.eieessvseielddvepeafea.lLefiYtgel.eitseenleelLaaadllqiprlkkaceeflkq 109
                 ++k+hk++La  S yF++l++s+ +++++sv+e el+ ve ++fe+ +L++iY +++ +i++    + +L +a++lqi  l  ++ + +++
  EFC35403.1  95 SIKVHKVFLALESLYFRTLLNSEfTESTNSVVEFELTSVEKDIFEQiILRYIYGERTlDIDKGLPYACTLCLAHYLQISPLECQLLQQMTK 185
                 69*********************777777888************86279****98751555667788889999******999888776665 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.13
                 HHHHHH-HHHHHHHTSTTTTTCCCEE CS
         BTB  28 avLaarSpyFkalftskeieessvse 53 
                   La  S+++++ +t    ++ s+++
  EFC35403.1 204 SMLAVNSSFLSQSLTAF-GKDISKKR 228
                 67999999999999999.45554443 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.9     8e-08   0.00072      33     100 ..     227     305 ..     203     308 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 8e-08
        BACK  33 kseeFleLskeqllellssdeLnvesEeevfeavlkWvkhdeeerkkh...........lpelLekvRlpllspeyLke 100
                 k +e ++L++e +l l+s d+Lnv++E+evf+ + +++  +e++ +++           ++++ ++vR+ +ls++ L++
  EFC35403.1 227 KRDEVMNLPVEFFLWLVSLDNLNVSNEDEVFDLIQEYIIRNEKSIRQNnpegfdqkpdiIEQVWSNVRVCFLSETKLLS 305
                 468999*******************************999988665541111111111155666667777777766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 2068.72
//
Query:       EFC35404.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.017   14.8   8.3        0.3   10.8   3.2    2.1  2  Cytochrom_NNT  NapC/NirT cytochrome c family, N-terminal regi
       0.13   12.2  10.3        4.1    7.5   2.9    3.1  2  Cytochrome_C7  Cytochrome c7 and related cytochrome c
       0.16   12.2  17.4       0.41   10.8   0.2    4.5  5  HNH            HNH endonuclease
        1.7    8.8   5.7         12    6.1   0.2    3.2  3  Zn-ribbon_8    Zinc ribbon domain


Domain annotation for each model (and alignments):
>> Cytochrom_NNT  NapC/NirT cytochrome c family, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.2   0.00092       4.1     115     163 ..      41      90 ..       7      94 .. 0.75
   2 ?   10.8   3.2   6.6e-05       0.3      72     145 ..     105     177 ..     102     189 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00092
  Cytochrom_NNT 115 rewarmkandsreCrnCHseeamdlekqkkkaakahkkaa.eeektCidC 163
                    + w + +++ +  Cr CH  e+    +  ++ +  h+k++   + +C +C
     EFC35404.1  41 ADWFKKNEKLEVLCRPCHGLEHARNVEGGSNWQYCHEKMItLMGGKCQEC 90 
                    5566666777788********99988999999999999983345588888 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 6.6e-05
  Cytochrom_NNT  72 HvPkelvkklarkiqaskevlaklvgkidtkekfeakrlelaerewarmka..ndsreCrnCHseeamdlekqkkk 145
                    Hv +++ + +++++qa++++  +  +    ++++++ +l la +e +++++  + +  C  CH +e+m+ +++++ 
     EFC35404.1 105 HVHHKNRDGVKKRAQATEDIDDEEREV---AQHVNEYKLILAMTEEQQVEKlkEFELLCDGCHYFEHMEKHARSEV 177
                    99999999***********99988444...4555555566666555555550045677**********99888765 PP

>> Cytochrome_C7  Cytochrome c7 and related cytochrome c
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   2.9   0.00091       4.1      40      73 .]      44      77 ..      16      90 .. 0.73
   2 ?    1.8   6.7     0.054   2.4e+02      33      61 ..     143     171 ..      76     184 .. 0.63

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00091
  Cytochrome_C7 40 skkaeveslt..CgaCHdgknafsvakkaeCakCHt 73
                    kk+e    +  C  CH  ++a +v++  + + CH+
     EFC35404.1 44 FKKNEKL--EvlCRPCHGLEHARNVEGGSNWQYCHE 77
                   3233333..255999999999998888888888885 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.054
  Cytochrome_C7  33 aemekgkskkaeveslt.....CgaCHdgknafs 61 
                    a++e+++++k      +     C+ CH  +++++
     EFC35404.1 143 AMTEEQQVEKL-----KefellCDGCHYFEHMEK 171
                    33333333333.....044455999998777764 PP

>> HNH  HNH endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.2     0.039   1.7e+02       8      25 ..       4      21 ..       1      27 [. 0.75
   2 ?    7.4   0.4    0.0011       4.8      33      47 .]      50      64 ..      45      64 .. 0.88
   3 ?   -3.5   0.2       2.9   1.3e+04      39      42 ..      74      77 ..      73      78 .. 0.50
   4 ?   10.8   0.2   9.2e-05      0.41       1      19 [.      87     109 ..      87     125 .. 0.85
   5 ?    2.2   0.1     0.047   2.1e+02      34      43 ..     157     166 ..     134     170 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.039
         HNH  8 fhksealevdHiipisqg 25
                 h ++a++ +H+  +++ 
  EFC35404.1  4 LHEVNAFTLHHVMYKDDD 21
                455589******998875 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0011
         HNH 33 lqllCksCHnkkhdr 47
                l+ lC+ CH  +h+r
  EFC35404.1 50 LEVLCRPCHGLEHAR 64
                889********9986 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 2.9
         HNH 39 sCHn 42
                 CH 
  EFC35404.1 74 YCHE 77
                4664 PP

  == domain 4  score: 10.8 bits;  conditional E-value: 9.2e-05
         HNH   1 CeyCgrkfhks....ealevdHi 19 
                 C++Cg  f+ +    + ++v+H+
  EFC35404.1  87 CQECGLSFESNselgKIFHVHHK 109
                 ***********988888888885 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.047
         HNH  34 qllCksCHnk 43 
                 +llC  CH  
  EFC35404.1 157 ELLCDGCHYF 166
                 79******65 PP

>> Zn-ribbon_8  Zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.14   6.4e+02      24      37 ..      48      63 ..      41      66 .. 0.69
   2 ?    6.1   0.2    0.0027        12       7      17 ..      86      96 ..      86     111 .. 0.80
   3 ?    2.8   0.3     0.029   1.3e+02       4      21 ..     156     172 ..     155     178 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.14
  Zn-ribbon_8 24 aplta.CPeCgs.evr 37
                 ++l++ C  C++ e  
   EFC35404.1 48 EKLEVlCRPCHGlEHA 63
                 4566679999987654 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0027
  Zn-ribbon_8  7 rCeeCghefev 17
                 +C+eCg  fe 
   EFC35404.1 86 KCQECGLSFES 96
                 7********93 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.029
  Zn-ribbon_8   4 YeYrCeeCghefevlqsi 21 
                  +e  C+ C+  fe++ + 
   EFC35404.1 156 FELLCDGCH-YFEHMEKH 172
                  4566****9.***99864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1244  (0.0693848); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1322.68
//
Query:       EFC35405.1  [L=280]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.036   14.2  15.5      0.052   13.7  15.5    1.3  1  YL1          YL1 nuclear protein
        0.2    9.9  17.6       0.25    9.6  17.6    1.2  1  CDC45        CDC45-like protein
       0.22   11.5  10.7        0.4   10.7  10.7    1.4  1  DUF4614      Domain of unknown function (DUF4614)
        2.9    7.0   5.3        3.3    6.8   5.3    1.2  1  Zip          ZIP Zinc transporter


Domain annotation for each model (and alignments):
>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7  15.5   1.2e-05     0.052      18     114 ..       7      96 ..       2     177 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.2e-05
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1  18 eeeedelellFaEeedDeefeseeeeeeeensDsdfdsdeedeesdeeedeeegekelerqerkkrkkekkkrkaqkkkskkkkkkqkkkkkkkidp 114
                 e + d+ e++    edD++ +++++e+  + +D d  s+e +  sd+e de+++  +  ++e++k     kkrk+++ k  kk+k+ ++   +k+d+
  EFC35405.1   7 E-PSDDEEKILDQMEDDNDQQQDASEKSHH-DDQDKLSEEFEHVSDNEHDENDSYSNS-EEEKAKS----KKRKRNSLKNGKKQKNLIEYAVQKLDE 96 
                 3.38999999**9******99999887764.887777777666677777776666532.2333333....333322222222222222222222222 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6  17.6   5.7e-05      0.25     128     218 ..       6     104 ..       1     139 [. 0.49

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 5.7e-05
       CDC45 128 eeeesdeedeeeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdeeee...sddddersrkrrrsepsakklrrq.....lkkerrkyeavlek 218
                  e+ +dee+  ++ edd+d++++ +e+++++d+++ +ee ++ + +++de+++   s++++ +s+kr+r++ ++ k++++      +k+ + ++ +l+k
  EFC35405.1   6 TEPSDDEEKILDQMEDDNDQQQDASEKSHHDDQDKLSEEFEHVSDNEHDENDSysnSEEEKAKSKKRKRNSLKNGKKQKNlieyaVQKLDEANRITLQK 104
                 333333333333334444444444444444444444444333333444444446435555555555555552222222224444444444444445544 PP

>> DUF4614  Domain of unknown function (DUF4614)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7  10.7     9e-05       0.4       8      89 ..      23     104 ..       9     121 .. 0.53

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 9e-05
     DUF4614   8 essssssesessssssessssrslssssesslssksssstdsksssqssestkkrskt....ktrttvketavqTsdpalayqwtk 89 
                 ++ +++++se+s++  + + s+  ++ s  ++ +++s+s++    +++++s+k+++++    k+++ + e avq  d+a  ++ +k
  EFC35405.1  23 ND-QQQDASEKSHHDDQDKLSEEFEHVSDNEHDENDSYSNSE---EEKAKSKKRKRNSlkngKKQKNLIEYAVQKLDEANRITLQK 104
                 22.222223323332333333333333333333333333333...333333333333355689999********999988888776 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   5.3   0.00075       3.3     113     169 ..      20      76 ..       5     188 .. 0.71

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.00075
         Zip 113 kasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeq 169
                 + ++++++ a++ks+++d+ + see e +  +++ ++ds ++  ++k ++++ + ++
  EFC35405.1  20 EDDNDQQQDASEKSHHDDQDKLSEEFEHVSDNEHDENDSYSNSEEEKAKSKKRKRNS 76 
                 445566667777777777777777775544444444443333333333332222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2484  (0.138546); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                        90  (0.0050198); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 1628.60
//
Query:       EFC35406.1  [L=134]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.15   12.3   1.6        3.5    7.9   0.3    2.3  2  MBDa            p55-binding region of Methyl-CpG-binding doma
       0.38   11.0   3.5        2.7    8.2   1.7    2.3  2  GluR_Homer-bdg  Homer-binding domain of metabotropic glutamat


Domain annotation for each model (and alignments):
>> MBDa  p55-binding region of Methyl-CpG-binding domain proteins MBD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.3   0.00039       3.5      26      51 ..       1      26 [.       1      31 [. 0.90
   2 ?    3.5   0.1    0.0088        79      27      60 ..      63      94 ..      57     102 .. 0.75

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00039
        MBDa 26 TssIFkqPVTritshpenkvrtdlke 51
                Ts I  +PVT+  s +  kv++  k+
  EFC35406.1  1 TSKILHKPVTVPVSPNITKVKSSFKD 26
                99*************99***999876 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.0088
        MBDa 27 ssIFkqPVTritshpenkvrtdlkeetlekPkQl 60
                ss  k+ +T+ ++h   +v  ++ + ++ek  Q+
  EFC35406.1 63 SSTLKSAITTTNNH--RNVPMEPFNLATEKRGQV 94
                8999**********..445555556666665555 PP

>> GluR_Homer-bdg  Homer-binding domain of metabotropic glutamate receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   1.7   0.00031       2.7       6      48 ..      22      64 ..      21      67 .. 0.87
   2 ?    2.1   0.0     0.026   2.3e+02       7      38 ..      98     129 ..      97     132 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00031
  GluR_Homer-bdg  6 SPFRDsvaslssssgSPvsesaLcsppsprYtsliLrdYsqSS 48
                    S F Ds+ s +s+ +S v   +++      +++  + d+  SS
      EFC35406.1 22 SSFKDSILSSASVASSCVASTIIGPKLPHSFKARPMPDFNNSS 64
                    77*******************9998888888888888888876 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.026
  GluR_Homer-bdg   7 PFRDsvaslssssgSPvsesaLcsppsprYts 38 
                      F  s++s++ +s S + +  + s    +Y+s
      EFC35406.1  98 KFKASIQSMERVSISKIDDGTFTSVTKRVYNS 129
                     588899***********999999999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (134 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       464  (0.0258799); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.34s 00:00:00.90 Elapsed: 00:00:00.57
# Mc/sec: 704.31
//
Query:       EFC35407.1  [L=163]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.4    9.8   3.3       0.67    9.0   0.1    2.0  2  DUF787    Borrelia burgdorferi protein of unknown function (D


Domain annotation for each model (and alignments):
>> DUF787  Borrelia burgdorferi protein of unknown function (DUF787)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.4    0.0059   1.1e+02      38     102 ..      12      76 ..       4     125 .. 0.64
   2 ?    9.0   0.1   3.7e-05      0.67      18      40 ..     133     155 ..     125     159 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.0059
      DUF787  38 kdaknfitlalsvtnledlleklekesdsskdkiakeksllkkamsdff.nsseeslksvvlyvyk 102
                 +   n++ la   + + ++ + ++++ ++ ++k+a e  ++ +a+ +   +  + +l+  ++y  +
  EFC35407.1  12 NSQSNLMKLATLNSSF-QQQQSIDQDMGTFEKKLAAEAEAFERALIEETsQPLRRALQRYEFYTRQ 76 
                 4455656665443444.4557899999999999999999988887654403345566666666544 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 3.7e-05
      DUF787  18 srvnyynpllvyksaklkvnkda 40 
                  + nyy pllvy s+  + n+ +
  EFC35407.1 133 VEKNYYGPLLVYSSNSSASNNSS 155
                 578************99988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1759  (0.0981092); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.36s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 915.35
//
Query:       EFC35408.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.4e-17   62.0   8.2    6.7e-17   61.4   8.2    1.3  1  Prefoldin_2     Prefoldin subunit
    2.7e-05   24.0  11.3      7e-05   22.7   2.6    2.4  2  Prefoldin       Prefoldin subunit
     0.0021   15.7   6.0     0.0025   15.4   6.0    1.0  1  DUF3584         Protein of unknown function (DUF3584)
  ------ inclusion threshold ------
      0.017   14.9   0.5      0.019   14.8   0.5    1.1  1  DUF4448         Protein of unknown function (DUF4448)
      0.026   12.9   8.7      0.028   12.8   8.7    1.1  1  Hemagglutinin   Haemagglutinin
       0.03   14.3   8.1       0.04   13.9   2.0    2.2  2  Sec2p           GDP/GTP exchange factor Sec2p
       0.03   14.2   5.5       0.35   10.8   0.4    2.1  2  Sec34           Sec34-like family
      0.032   13.8   7.7        1.2    8.7   3.2    2.2  2  PI3K_P85_iSH2   Phosphatidylinositol 3-kinase regulatory subu
      0.036   13.6   0.3      0.066   12.7   0.2    1.4  1  TRAP-delta      Translocon-associated protein, delta subunit 
      0.044   13.6   1.6          2    8.3   0.3    2.4  2  DASH_Dam1       DASH complex subunit Dam1
      0.046   13.8  12.6        9.5    6.3  12.8    2.2  1  TssO            Type VI secretion system, TssO
      0.052   14.2   0.5      0.052   14.2   0.5    2.0  2  Fe-S_assembly   Iron-sulphur cluster assembly
      0.059   11.3   5.7      0.065   11.1   5.7    1.1  1  V_ATPase_I      V-type ATPase 116kDa subunit family
      0.064   11.9   8.3       0.11   11.1   8.1    1.4  1  FapA            Flagellar Assembly Protein A
      0.073   12.5   7.9       0.64    9.4   0.5    2.0  2  DUF4618         Domain of unknown function (DUF4618)
      0.081   12.0   5.7      0.034   13.3   2.4    1.7  2  Effector_1      Effector from type III secretion system
      0.099   12.8   0.6       0.98    9.6   0.4    2.0  2  Metal_resist    Heavy-metal resistance
        0.1   12.9   9.7       0.43   10.9   1.1    2.3  2  Spc24           Spc24 subunit of Ndc80
       0.12   12.4  11.8       0.93    9.6   3.4    2.1  2  NYD-SP28        Sperm tail
       0.12   11.4   0.3       0.16   11.1   0.3    1.1  1  Complex1_49kDa  Respiratory-chain NADH dehydrogenase, 49 Kd s
       0.16   11.7   6.2       0.39   10.4   0.4    2.0  2  BCAS2           Breast carcinoma amplified sequence 2 (BCAS2)
       0.24   11.2  11.2       0.61    9.9   4.9    2.3  2  CdvA            CdvA-like coiled-coil domain
       0.25   11.3   5.5        1.3    8.9   0.7    2.3  2  AAA_lid_9       AAA lid domain
       0.27   11.0   3.9       0.37   10.5   3.9    1.2  1  AAA_11          AAA domain
        0.3   10.5   8.7        4.5    6.6   8.7    2.1  1  FliD_C          Flagellar hook-associated protein 2 C-terminu
       0.31   11.5   6.9        0.5   10.8   0.4    2.5  2  FlaC_arch       Flagella accessory protein C (FlaC)
       0.31   10.3   2.6       0.24   10.7   0.7    1.5  1  DUF3810         Protein of unknown function (DUF3810)
       0.32   11.5   4.9        1.4    9.4   0.4    2.1  2  DUF4140         N-terminal domain of unknown function (DUF414
       0.36   11.2   4.1        2.6    8.4   0.5    2.1  2  DUF2935         Domain of unknown function (DUF2935)
       0.38   10.8  12.5        3.6    7.7   0.6    2.2  2  TPR_MLP1_2      TPR/MLP1/MLP2-like protein
       0.44   11.2  10.2        1.4    9.6   1.3    2.2  2  BST2            Bone marrow stromal antigen 2
       0.46   10.3   7.4       0.49   10.2   3.8    2.0  2  PRKCSH-like     Glucosidase II beta subunit-like
       0.48    9.7   6.3       0.78    9.0   6.3    1.3  1  DUF4407         Domain of unknown function (DUF4407)
       0.55   10.5  12.5        2.3    8.5   0.6    2.2  2  Seryl_tRNA_N    Seryl-tRNA synthetase N-terminal domain
       0.62   10.2  11.7       0.12   12.4   1.0    2.4  2  bZIP_1          bZIP transcription factor
       0.86    9.8   7.2        2.4    8.3   0.6    2.2  2  Fib_alpha       Fibrinogen alpha/beta chain family
       0.88    9.8   8.9        5.2    7.4   2.2    2.4  2  XhlA            Haemolysin XhlA
        1.6    9.1   8.8        3.2    8.2   2.2    2.2  2  PRP1_N          PRP1 splicing factor, N-terminal
        1.6    9.2  12.8       0.96   10.0  10.0    1.8  2  APG6_N          Apg6 coiled-coil region
        1.7    7.8   6.1        2.4    7.4   6.1    1.3  1  TMPIT           TMPIT-like protein
        2.6    8.8   8.8        4.1    8.2   1.6    2.4  2  FliD_N          Flagellar hook-associated protein 2 N-terminu
        3.8    7.0   5.5        1.3    8.5   2.2    1.7  2  SseC            Secretion system effector C (SseC) like famil


Domain annotation for each model (and alignments):
>> Prefoldin_2  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.4   8.2   1.6e-19   6.7e-17       1     105 [.      24     125 ..      24     126 .. 0.96

  Alignments for each domain:
  == domain 1  score: 61.4 bits;  conditional E-value: 1.6e-19
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS-TT--EEEEETTEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2   1 qelinkfqqlqqqlqqlaqqikqletqlkelelvleelelldedtkvyklvGdvlvkqdkeevkeeLeerketlekeiktlekqleklekeleelkee 98 
                  q++in+f++++ +  +l+ +i++l+++l++l+++++e+     d ++ + vG+++v+++ +++++ L+erke+++k +k  +k+ +++e++++elk++
   EFC35408.1  24 QKKINNFSRINVRFNELEREITDLKEELNKLNDASDEIFIS--D-NISYVVGELFVEVNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKAN 118
                  89***********************************9543..3.799************************************************** PP

                  HHCCTS- CS
  Prefoldin_2  99 lqkklqq 105
                  l++++++
   EFC35408.1 119 LYARFGS 125
                  *****86 PP

>> Prefoldin  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.1    0.0081       3.5      83     110 ..      34      61 ..      31      68 .. 0.83
   2 !   22.7   2.6   1.6e-07     7e-05      68     114 ..      73     119 ..      69     123 .. 0.94

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0081
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  83 kkkleelekqlekleeeleklkdqittl 110
                 + + +ele+ +++l+eel+kl d+ +++
  EFC35408.1  34 NVRFNELEREITDLKEELNKLNDASDEI 61 
                 5577899999999999999999988776 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 1.6e-07
                 TEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  68 gyyveksleeAiellkkkleelekqlekleeeleklkdqittleanl 114
                 + +ve+++++A++ll++++e+++k l++ ++e +++ +++++l anl
  EFC35408.1  73 ELFVEVNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 579****************************************9997 PP

>> DUF3584  Protein of unknown function (DUF3584)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   6.0   5.9e-06    0.0025     826     936 ..      11     127 ..       2     130 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 5.9e-06
     DUF3584 826 elesaaeeleqeltrlied...tklerkklekerkalekqldqldenlr..klrdllskl.aelkldadaeqaegelaerlaaleelkrkrerlsedvk 918
                 ++e++  +++ e +++i++    + + ++le+e   l++ l++l+++     + d +s++ +el ++ +a+qae+ l+er ++++ +++ r+++ +d++
  EFC35408.1  11 TTEDNTYQITWEDQKKINNfsrINVRFNELEREITDLKEELNKLNDASDeiFISDNISYVvGELFVEVNADQAEKLLDERKEKVKKDLKDRQKEFKDIE 109
                 4445555555444444444111445666777777777777777777666233699******************************************** PP

     DUF3584 919 kalerfkgvlkdksgsgl 936
                 ++++++k++l +  gs +
  EFC35408.1 110 NKMKELKANLYARFGSHI 127
                 **********88888865 PP

>> DUF4448  Protein of unknown function (DUF4448)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.5   4.4e-05     0.019      31     108 ..       6      90 ..       3     132 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.4e-05
     DUF4448  31 kegselkvgktYyiTWdprfFdekenekVkihlsyvkestkekglk........ksffssdwlpnsdGfypltvdeewlkgkkser 108
                 k+ ++ + ++tY iTW  +    ++ ++++++++ ++++  + +++        +++f sd+++   G + ++v+ +  ++  +er
  EFC35408.1   6 KQATTTTEDNTYQITWEDQKK-INNFSRINVRFNELEREITDLKEElnklndasDEIFISDNISYVVGELFVEVNADQAEKLLDER 90 
                 56678889********87765.58999********9999888666699******99******************998777644444 PP

>> Hemagglutinin  Haemagglutinin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   8.7   6.6e-05     0.028     373     461 ..      12     105 ..       1     118 [. 0.68

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 6.6e-05
                    HHHHHHHHHHHHHHTTTEEEBXSSXXTTTTHHHHHHHH...HHHHHHHHH.HHHHHHHHH.HHHHHHHHHHHHHHHHHHHHHHHHHHGGGEEEE CS
  Hemagglutinin 373 inkitkkvnsliekenkqleavgkelnelekrieeldk...kvddgfldv.ityniellv.llenerildfedsnvknleekvkkqlkdnakei 461
                     ++ t ++    +k+ +++ ++   +nele++i +l++   k++d   ++ i+ ni  +v  l  e   d  ++ + + +ekvkk lkd  ke 
     EFC35408.1  12 TEDNTYQITWEDQKKINNFSRINVRFNELEREITDLKEelnKLNDASDEIfISDNISYVVgELFVEVNADQAEKLLDERKEKVKKDLKDRQKEF 105
                    4455556666667788888888888888888888887622245566666524556666653355677777778888888999999999998885 PP

>> Sec2p  GDP/GTP exchange factor Sec2p
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.5      0.11        47      59      87 ..      30      58 ..       2      61 .. 0.65
   2 ?   13.9   2.0   9.4e-05      0.04      40      81 ..      79     120 ..      74     126 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.11
                HTTHCHCCCHCTSSSSHHHHCTTTXXXXX CS
       Sec2p 59 LkeketlleslqeqLkeLkevlekmeees 87
                 +  +  +++l+ +  +Lke l+k+++ s
  EFC35408.1 30 FSRINVRFNELEREITDLKEELNKLNDAS 58
                44555566666777777777777766665 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 9.4e-05
                 HHHHHHHHHHHHHHHHHHHHTTHCHCCCHCTSSSSHHHHCTT CS
       Sec2p  40 aarkekealekkneklkeqLkeketlleslqeqLkeLkevle 81 
                 +a + ++ l++++ek+k+ Lk+ ++ +++ ++++keLk  l+
  EFC35408.1  79 NADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANLY 120
                 677889999*****************************8775 PP

>> Sec34  Sec34-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.7     0.019       8.2      30      64 ..      27      61 ..       2      69 .. 0.62
   2 ?   10.8   0.4   0.00081      0.35       7      46 ..      78     118 ..      75     132 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.019
       Sec34 30 eekfksvsektsslheaceqlleeqkrleelaeei 64
                 ++f++++ + ++l+++  +l ee ++l++ ++ei
  EFC35408.1 27 INNFSRINVRFNELEREITDLKEELNKLNDASDEI 61
                45556666666666666666666666666666655 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00081
       Sec34   7 skeeecdelleq.tdealeqLeeleekfksvsektsslhea 46 
                  + ++ ++ll++  ++++++L++ +++fk++++k+++l+++
  EFC35408.1  78 VNADQAEKLLDErKEKVKKDLKDRQKEFKDIENKMKELKAN 118
                 567788888866157899*******************9976 PP

>> PI3K_P85_iSH2  Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.1    0.0063       2.7     118     139 ..      37      58 ..       6      63 .. 0.73
   2 ?    8.7   3.2    0.0028       1.2      98     132 ..      85     119 ..      76     122 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0063
  PI3K_P85_iSH2 118 ereleReinalkpellqLqkrk 139
                      eleRei+ lk el +L+   
     EFC35408.1  37 FNELEREITDLKEELNKLNDAS 58 
                    4577888888888887776555 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0028
  PI3K_P85_iSH2  98 kelhsskekLeedlkqqkeeereleReinalkpel 132
                    k l + kek+++dlk + +e + +e ++ +lk +l
     EFC35408.1  85 KLLDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                    567889**************************987 PP

>> TRAP-delta  Translocon-associated protein, delta subunit precursor (TRAP-delta)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2   0.00015     0.066      67      98 ..       8      39 ..       3      62 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 0.00015
  TRAP-delta 67 vakseetnkYQVSwteehkkassgtyevklfD 98
                ++ ++e+n+YQ++w ++ k  +  +++v++ +
  EFC35408.1  8 ATTTTEDNTYQITWEDQKKINNFSRINVRFNE 39
                678899**********9999999999999976 PP

>> DASH_Dam1  DASH complex subunit Dam1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.3    0.0047         2       4      29 ..      36      61 ..      33      66 .. 0.89
   2 ?    4.1   0.0     0.091        39       3      19 ..     103     119 ..      95     125 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0047
   DASH_Dam1  4 afaeLaDsletLdknledLqqihesL 29
                +f+eL+ ++++L++ l++L++ ++++
  EFC35408.1 36 RFNELEREITDLKEELNKLNDASDEI 61
                79******************988765 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.091
   DASH_Dam1   3 pafaeLaDsletLdknl 19 
                 ++f++++ ++++L++nl
  EFC35408.1 103 KEFKDIENKMKELKANL 119
                 56777777777777775 PP

>> TssO  Type VI secretion system, TssO
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  12.8     0.022       9.5      44     140 ..      24     118 ..      10     119 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.022
        TssO  44 lkelerkkkfeekqkelkkkvdsiykkIdsLkpevnavfleneIkkdlndikntygknssdeRykmyaqi.akfykmlledKkelksvseniklfkkq 140
                  k++++ ++++ + +el+ ++  +++++++L+    ++f+ ++I++ ++++    + ++ ++   + +    k  k+l +  ke k+++++ k++k +
  EFC35408.1  24 QKKINNFSRINVRFNELEREITDLKEELNKLNDASDEIFISDNISYVVGELFVEVNADQAEK---LLDERkEKVKKDLKDRQKEFKDIENKMKELKAN 118
                 489*********************************************99877776666665...333330333344555556666677777777666 PP

>> Fe-S_assembly  Iron-sulphur cluster assembly
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.5   0.00012     0.052       5      49 ..      15      60 ..      14      63 .. 0.78
   2 ?   -0.5   0.1       4.7     2e+03      23      32 ..     101     110 ..      80     119 .. 0.51

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 0.00012
  Fe-S_assembly  5 dseeIAiaLyekypdvdpltvrFtdLhewvleL.pefdddpeksnE 49
                   ++++I  + ++k +++  ++vrF +L++ +++L +e ++ +++s+E
     EFC35408.1 15 NTYQITWEDQKKINNFSRINVRFNELEREITDLkEELNKLNDASDE 60
                   57788888889999*******************4445555555554 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 4.7
  Fe-S_assembly  23 ltvrFtdLhe 32 
                    ++  F+d+++
     EFC35408.1 101 RQKEFKDIEN 110
                    3333333333 PP

>> V_ATPase_I  V-type ATPase 116kDa subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   5.7   0.00015     0.065      55     146 ..      14     106 ..       1     129 [. 0.64

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00015
  V_ATPase_I  55 keeeaeesleapeekeldeleeelekleeelkelnenleklkkelnelvelkavlekakefleeeeeeeeeeeseeeeee.keeeeeeeseee 146
                  ++ + + +++++ +++++++ ++++le+e+++l+e+l+kl++   e+    ++   + e++ e +++++e+  +e++e+ k++ +++++e +
  EFC35408.1  14 DNTYQITWEDQKKINNFSRINVRFNELEREITDLKEELNKLNDASDEIFISDNISYVVGELFVEVNADQAEKLLDERKEKvKKDLKDRQKEFK 106
                 222235667777888889999999999999999999999999999999999999999999998775555555554444443322222222111 PP

>> FapA  Flagellar Assembly Protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   8.1   0.00025      0.11     325     412 ..      32     116 ..      23     131 .. 0.52

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00025
        FapA 325 eievgldepelkeklkeleeeleeleeeleklkkk.....ikklpklka.ekqlesekkeqlkklletkeklkeeleeleeelkelkeeleskk 412
                 +i         + +++ele+e+ +l+eel+kl+++     i+ + +  + e  +e +  +  k l e kek k++l++ ++e+k++++++++ k
  EFC35408.1  32 RI---------NVRFNELEREITDLKEELNKLNDAsdeifISDNISYVVgELFVEVNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELK 116
                 33.........34445555555555555555555555555444444222122223333333334445556667777777777777777776662 PP

>> DUF4618  Domain of unknown function (DUF4618)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.5    0.0015      0.64     173     223 ..       8      58 ..       1      64 [. 0.82
   2 ?    7.2   1.6     0.007         3      66     104 ..      81     119 ..      68     121 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0015
     DUF4618 173 tlkatqeaLlqktlenqvlkkeiekfrefieeleeeipeLkaeveqLqaqa 223
                 + + t++   q t+e q+  ++  +     +ele ei +Lk+e+++L+   
  EFC35408.1   8 ATTTTEDNTYQITWEDQKKINNFSRINVRFNELEREITDLKEELNKLNDAS 58 
                 34457888889999999999999999999****************998765 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.007
     DUF4618  66 eqakaeLqeweekeekklekLeqqleqlnakvqklqeel 104
                 +qa++ L+e +ek++k+l++ +++ + +++k+++l+ +l
  EFC35408.1  81 DQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 678888999999999999999999999999999988765 PP

>> Effector_1  Effector from type III secretion system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.4     0.097        41      54      94 ..      12      62 ..       1      69 [. 0.44
   2 ?   13.3   2.4     8e-05     0.034     188     258 ..      44     119 ..      36     123 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.097
  Effector_1 54 karellkfqakaeseeskiqqeilese..........tkkekLepvktslf 94
                ++ +++++  + +++++ + +  +  +          +  +kL+ +++++f
  EFC35408.1 12 TEDNTYQITWEDQKKINNFSRINVRFNelereitdlkEELNKLNDASDEIF 62
                444444555555555554444444444000111111155555555555555 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 8e-05
  Effector_1 188 kdklakEkeqv...rkdlksaekAkekvkellkrveadk..kltteqkaklkdelngYadeleaiveqLaelkvll 258
                 ++ l++E +++      ++++ +   +v el  +v+ad+  kl +e+k k+k+ l+   +e++ i ++++elk  l
  EFC35408.1  44 ITDLKEELNKLndaSDEIFISDNISYVVGELFVEVNADQaeKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 4556666555411145799999999*************999*******************************9877 PP

>> Metal_resist  Heavy-metal resistance
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.76   3.2e+02      61      79 ..      36      54 ..      18      59 .. 0.83
   2 ?    9.6   0.4    0.0023      0.98      40      80 ..      83     123 ..      80     126 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.76
                  HHHHHHHHHHHHHHHHHHH CS
  Metal_resist 61 elralrrelraarrelaal 79
                  ++ +l+re+++ ++el+ l
    EFC35408.1 36 RFNELEREITDLKEELNKL 54
                  68999**********9987 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0023
                   HS-TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Metal_resist  40 algLpaeqraelraalrdharelralrrelraarrelaall 80 
                   a++L +e+ +++++ l+d+++e+ + ++ + + ++ l+a +
    EFC35408.1  83 AEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANLYARF 123
                   678999******************************99876 PP

>> Spc24  Spc24 subunit of Ndc80
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   1.1     0.001      0.43       9      37 ..      33      61 ..      18      87 .. 0.61
   2 ?    6.2   3.0     0.028        12       2      64 ..      87     124 ..      76     133 .] 0.50

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.001
       Spc24  9 iakelsdleselesleselaelkeeleel 37
                i    ++le+e+++l++el++l++  +e+
  EFC35408.1 33 INVRFNELEREITDLKEELNKLNDASDEI 61
                33344555555555555555555555554 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.028
       Spc24   2 ldnekfriakelsdleselesleselaelkeeleeleeeseekeservedetllklklYrsLG 64 
                 ld++k ++ k+l+d ++e +++e+                         + + lk++lY  +G
  EFC35408.1  87 LDERKEKVKKDLKDRQKEFKDIEN-------------------------KMKELKANLYARFG 124
                 233333333444444444444444.........................44446666666665 PP

>> NYD-SP28  Sperm tail
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   1.3    0.0065       2.8      24      69 ..      19      62 ..       2      68 .. 0.81
   2 ?    9.6   3.4    0.0022      0.93      11      47 ..      81     117 ..      76     120 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0065
    NYD-SP28 24 leeeaksseekfeeinekWreilrknkpqeLrkeleeqkqaceeli 69
                +  e+++   +f +in +++e++r+    +L++el++++ a +e+ 
  EFC35408.1 19 ITWEDQKKINNFSRINVRFNELEREI--TDLKEELNKLNDASDEIF 62
                5568888999************9986..69*********9999985 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0022
    NYD-SP28  11 reeeelrqerkekleeeaksseekfeeinekWreilr 47 
                  + e+l  erkek++++ k  +++f++i++k++e+++
  EFC35408.1  81 DQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKA 117
                 56788999************************99986 PP

>> Complex1_49kDa  Respiratory-chain NADH dehydrogenase, 49 Kd subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.3   0.00037      0.16     129     207 ..      24     122 ..       6     126 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00037
                     -SSBSHHHHHHHHHHHHHHHHHHHHHHHHT--...S-SB-.--TTTS---.................GGGGGT-HHHHHHHHHHHHS-----SEE CS
  Complex1_49kDa 129 geegDvydRylvrveEmrqSlkIieqaleklpe..gpvla.edkkvalpk.................keevkksmealihhfklvtegfkvpkge 203
                     +++ + ++R+ vr++E++  +  ++  l+kl++  +++ + ++ ++++ +                 ke+vkk++++  ++fk + +++k  k +
      EFC35408.1  24 QKKINNFSRINVRFNELEREITDLKEELNKLNDasDEIFIsDNISYVVGElfvevnadqaekllderKEKVKKDLKDRQKEFKDIENKMKELKAN 118
                     4567899************************876655555155555555589999999999999999********************99999988 PP

                     EEEE CS
  Complex1_49kDa 204 vyaa 207
                     +ya+
      EFC35408.1 119 LYAR 122
                     8876 PP

>> BCAS2  Breast carcinoma amplified sequence 2 (BCAS2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.9     0.068        29     160     204 ..       6      52 ..       4      54 .. 0.79
   2 ?   10.4   0.4   0.00092      0.39     132     186 ..      76     130 ..      68     132 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.068
       BCAS2 160 eQeeageeLksleekWr..elvsknleieaaceeleaeieelkrqaa 204
                 +Q ++ +e ++++ +W   + +++  +i++   ele+ei +lk++ +
  EFC35408.1   6 KQATTTTEDNTYQITWEdqKKINNFSRINVRFNELEREITDLKEELN 52 
                 67777777788888886115688999****************99865 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00092
       BCAS2 132 leaelkklekeleetkeeieevnrqRkseQeeageeLksleekWrelvsknleie 186
                 +e  ++++ek l+e ke++++  ++R++e +++++++k+l+++ ++  ++ +++e
  EFC35408.1  76 VEVNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANLYARFGSHINLE 130
                 5777899*********************************999888777777666 PP

>> CdvA  CdvA-like coiled-coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.4     0.037        16      26      44 ..      39      57 ..      29      74 .. 0.73
   2 ?    9.9   4.9    0.0014      0.61      27      69 ..      80     122 ..      57     126 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.037
        CdvA 26 kleealkklkekakelkek 44
                +le+++++lke+ ++l++ 
  EFC35408.1 39 ELEREITDLKEELNKLNDA 57
                5666666666666666654 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0014
        CdvA  27 leealkklkekakelkeklkkrlkeledqikslekalanlkis 69 
                  ++a k l+e+++++k+ lk r ke +d  ++++++ anl  +
  EFC35408.1  80 ADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANLYAR 122
                 4566667899999************999999999999998665 PP

>> AAA_lid_9  AAA lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.3     0.063        27      68      93 ..      34      59 ..       4      68 .. 0.73
   2 ?    8.9   0.7    0.0031       1.3      47      84 ..      81     118 ..      79     126 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.063
   AAA_lid_9 68 peeleklekelaklekekealekeee 93
                + + ++le+e+++l++e ++l+++++
  EFC35408.1 34 NVRFNELEREITDLKEELNKLNDASD 59
                34466677777777777777666554 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0031
   AAA_lid_9  47 dkAIDllDeaaarvrlkkeskpeeleklekelakleke 84 
                 d A  llDe   +v+ + +++++e +++e+++++l+ +
  EFC35408.1  81 DQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKAN 118
                 677789***************************99875 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   3.9   0.00086      0.37     121     190 ..      29     121 ..       2     129 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00086
      AAA_11 121 e.......kaqlakeiskeleklakelrafeeeeek................eklkkskekskskleqerrklkkerkelskeleeaeeslee 190
                 +        ++l +ei++ +e+l+k ++a++e + +                ++ +k  +++k+k ++++++ +ke k+++++++e +++l +
  EFC35408.1  29 NfsrinvrFNELEREITDLKEELNKLNDASDEIFISdnisyvvgelfvevnaDQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANLYA 121
                 133344434455666666666666666666666666999*********999988888899999999999999999999999999999988765 PP

>> FliD_C  Flagellar hook-associated protein 2 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   8.7     0.011       4.5     185     229 ..      80     124 ..       2     129 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.011
                 HSTT.SHHHHHHHHXXXXHHHHHHHHHHHHHCHHHHHHHHHHHHH CS
      FliD_C 185 vkssngtlqtasknltkqikdldkkiedldkrletleerlkkqfa 229
                  +  ++ l++++++++k++kd +k+ +d+++++++l++ l+++f 
  EFC35408.1  80 ADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANLYARFG 124
                 355668899*********************************995 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.4    0.0012       0.5       8      35 ..      29      56 ..      24      62 .. 0.83
   2 ?    3.6   1.2      0.21        92      11      36 ..      93     118 ..      76     122 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0012
   FlaC_arch  8 klsklsteletvkkeneelsksveelke 35
                 +s++ ++++ +++e+ +l++++++l++
  EFC35408.1 29 NFSRINVRFNELEREITDLKEELNKLND 56
                5677888999999999999999999997 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.21
   FlaC_arch  11 klsteletvkkeneelsksveelken 36 
                 k++  l+  +ke+++++++ +elk n
  EFC35408.1  93 KVKKDLKDRQKEFKDIENKMKELKAN 118
                 45555566666666666666666655 PP

>> DUF3810  Protein of unknown function (DUF3810)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.7   0.00055      0.24     235     287 ..      68     121 ..      62     128 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00055
     DUF3810 235 syvlnalyka.deeayeellktispevledlkeereywekyegtveevsdkvnd 287
                 syv+ +l+ + + +++e+ll++ +++v++dlk++++ ++ +e++++e++ +++ 
  EFC35408.1  68 SYVVGELFVEvNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANLYA 121
                 788888887779999****************************99999988875 PP

>> DUF4140  N-terminal domain of unknown function (DUF4140)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.4    0.0032       1.4      51      87 ..      14      57 ..       2      62 .. 0.55
   2 ?    4.2   0.5      0.13        57      60      93 ..      84     117 ..      68     121 .. 0.59

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0032
     DUF4140 51 dvqvervpnreaeee.......elkalraeleeledelaalede 87
                d +++ +++++++ +       + ++l++e++ l++el++l+d+
  EFC35408.1 14 DNTYQITWEDQKKINnfsrinvRFNELEREITDLKEELNKLNDA 57
                44444444444444445556655666666666666666666665 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.13
     DUF4140  60 reaeeeelkalraeleeledelaaledelaaaea 93 
                 ++  +e+ +++++ l+  ++e +++e++++ ++a
  EFC35408.1  84 EKLLDERKEKVKKDLKDRQKEFKDIENKMKELKA 117
                 3333334566666666666666666666666665 PP

>> DUF2935  Domain of unknown function (DUF2935)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.2       0.1        44      61      93 ..      23      55 ..       4      69 .. 0.72
   2 ?    8.4   0.5    0.0061       2.6      22      56 ..      84     118 ..      75     131 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.1
     DUF2935 61 sseleeavakLneealkltreliqFkkellekv 93
                ++++ ++++++n ++ +l re++++k+el +  
  EFC35408.1 23 DQKKINNFSRINVRFNELEREITDLKEELNKLN 55
                455667777888888888888888888877654 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0061
     DUF2935  22 ealldpkekdlikeakefkkeFekllaeavelseg 56 
                 e+lld++ +++ k +k+ +keF++++++  el+  
  EFC35408.1  84 EKLLDERKEKVKKDLKDRQKEFKDIENKMKELKAN 118
                 789**************************999765 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.6    0.0084       3.6      43      86 ..      14      57 ..       2      62 .. 0.70
   2 ?    7.4   5.5    0.0099       4.2      79     117 ..      79     117 ..      76     118 .. 0.91

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0084
  TPR_MLP1_2 43 qkYerelvkhaedvkelqalreelnelkaeiaelkaeaesakae 86
                ++  +   +  + +++ ++++ ++nel+ ei++lk+e+++++ +
  EFC35408.1 14 DNTYQITWEDQKKINNFSRINVRFNELEREITDLKEELNKLNDA 57
                44445555667778888888888899999999999988887765 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0099
  TPR_MLP1_2  79 eaesakaeleeseesweeqkeelekelselekriedlne 117
                 +a++a++ l+e +e+ ++  +  +ke +++e+++++l++
  EFC35408.1  79 NADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKA 117
                 6899********************************986 PP

>> BST2  Bone marrow stromal antigen 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   1.3    0.0032       1.4      55      86 ..      24      55 ..       1      60 [. 0.64
   2 ?    6.5   2.1     0.029        12      50      82 ..      87     119 ..      76     123 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.0032
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        BST2 55 ekekaqsqkqqakvqelqgeikkLnqkLqdae 86
                +k+  +  + + + +el++ei++L+++L++ +
  EFC35408.1 24 QKKINNFSRINVRFNELEREITDLKEELNKLN 55
                344444455667899*************9876 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.029
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        BST2  50 LkasLekekaqsqkqqakvqelqgeikkLnqkL 82 
                 L +  ek k   +++q++ +++++++k+L+ +L
  EFC35408.1  87 LDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 444445555555666777777777777777776 PP

>> PRKCSH-like  Glucosidase II beta subunit-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.1      0.37   1.6e+02      23      59 ..      10      46 ..       3      60 .. 0.74
   2 ?   10.2   3.8    0.0011      0.49     121     162 ..      78     119 ..      52     133 .] 0.80

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.37
  PRKCSH-like 23 apdklelykPdengnwkclnsseiklsfdqvnddycd 59
                 ++++ + y+ + +++ k  n s+i+++f+ ++ +  d
   EFC35408.1 10 TTTEDNTYQITWEDQKKINNFSRINVRFNELEREITD 46
                 4567778888888888888888888888877655544 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.0011
  PRKCSH-like 121 eiarkfeelleeankkvkkglkikeelllaakkkldelkkkl 162
                    a+++e+ll+e+++kvkk lk +++  +  ++k++elk++l
   EFC35408.1  78 VNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                  468899********************************9764 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   6.3    0.0018      0.78     121     232 ..      11     118 ..       2     129 .. 0.44

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0018
     DUF4407 121 kelkeqlaaa.....ltaelaeleaqiaalqaeidaaearldalraeaqkeldgtkgtgttgvaGkgpaakekkaqldaaqaelaelkakldatarlaa 214
                 ++ +++++ +       +  ++++ + ++l++ei+ ++++l++l+++  +e++   ++ ++ v G+  +  +    +d+a++ l+e k+k   +++l++
  EFC35408.1  11 TTEDNTYQITwedqkKINNFSRINVRFNELEREITDLKEELNKLNDA-SDEIFI--SDNISYVVGELFVEVN----ADQAEKLLDERKEK--VKKDLKD 100
                 22222222221111212222333333336666666666666655443.336665..6666666666554433....44444444444444..4455555 PP

     DUF4407 215 lraelaeleaerakeraa 232
                 +++e +++e+++++ +a+
  EFC35408.1 101 RQKEFKDIENKMKELKAN 118
                 555555555555444443 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.6    0.0054       2.3      57      99 ..      25      60 ..       3      65 .. 0.58
   2 ?    6.6   5.5     0.021       8.8      69     102 ..      84     117 ..      64     121 .. 0.66

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0054
                  HHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N 57 keIgkakkkkedaeeliaevkelkeelkaleaelkeleaelek 99
                  k+I        + +++  + +el  e+ +l++el++l+++ ++
    EFC35408.1 25 KKIN-------NFSRINVRFNELEREITDLKEELNKLNDASDE 60
                  3333.......34444444555555555555555555554444 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.021
                   TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC CS
  Seryl_tRNA_N  69 aeeliaevkelkeelkaleaelkeleaeleklll 102
                    + l ++ +++k++lk+ ++e k++e+++++l +
    EFC35408.1  84 EKLLDERKEKVKKDLKDRQKEFKDIENKMKELKA 117
                   3345566677777777777777777777777644 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.0   0.00029      0.12      22      57 ..      24      59 ..      24      61 .. 0.89
   2 ?    2.4   3.8      0.41   1.8e+02      23      46 ..      90     116 ..      81     121 .. 0.55

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00029
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1 22 qRKqaeieeLerrvkaLekeNksLkseleelkkeve 57
                q+K    ++   r+ +Le e ++Lk+el++l++ ++
  EFC35408.1 24 QKKINNFSRINVRFNELEREITDLKEELNKLNDASD 59
                678888889999********************9876 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.41
                 HHHHHHHHHHHHHHHHH...HHHHHHH CS
      bZIP_1  23 RKqaeieeLerrvkaLe...keNksLk 46 
                 RK++  + L++r k+++   +++k+Lk
  EFC35408.1  90 RKEKVKKDLKDRQKEFKdieNKMKELK 116
                 666666666655554431003444443 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   1.1      0.05        21      52      98 ..       7      52 ..       1      68 [. 0.63
   2 ?    8.3   0.6    0.0057       2.4      24      55 ..      85     116 ..      77     128 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.05
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH CS
   Fib_alpha 52 keaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketid 98
                + + ++  ++++++ e+qk+ + n + i+   +ele+ei++lke+++
  EFC35408.1  7 QATTTTEDNTYQITWEDQKKIN-NFSRINVRFNELEREITDLKEELN 52
                3444444556666666666666.566666666777777777776654 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0057
                 HCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHH CS
   Fib_alpha  24 dlllkyekdvkkdlekleneleeisnstkeae 55 
                 +ll++ +++vkkdl++ ++e+++i+n+ ke +
  EFC35408.1  85 KLLDERKEKVKKDLKDRQKEFKDIENKMKELK 116
                 56677777777777777777777777766654 PP

>> XhlA  Haemolysin XhlA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.6     0.025        11       2      27 ..      33      58 ..      24      62 .. 0.59
   2 ?    7.4   2.2     0.012       5.2      16      48 ..      87     119 ..      77     128 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.025
        XhlA  2 ikerlerietkldnleervdkleeka 27
                i  r +++e+++ +l+e+++kl++ +
  EFC35408.1 33 INVRFNELEREITDLKEELNKLNDAS 58
                34445555555555555555555555 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.012
        XhlA  16 leervdkleekaaeaeekiknleedlkklesnq 48 
                 l+er +k++++    +++ k +e+++k+l++n+
  EFC35408.1  87 LDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 455667899999999999999999999999987 PP

>> PRP1_N  PRP1 splicing factor, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.6     0.066        28     109     139 ..      25      54 ..       2      62 .. 0.49
   2 ?    8.2   2.2    0.0074       3.2      84     128 ..      75     119 ..      64     122 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.066
                 ......-HHHHHHHHHHHHHTT--HHHHHS- CS
      PRP1_N 109 kvreekpkiqeqFadlkrkLaevseeeWeni 139
                 k  ++ ++i+ +F++l r++++++ee  +++
  EFC35408.1  25 KKINNFSRINVRFNELEREITDLKEE-LNKL 54 
                 22222255555555555555555432.3333 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0074
                 --HHHHHHHHHHHHHHTT-------......-HHHHHHHHHHHHH CS
      PRP1_N  84 yeeiderlderrkkrreakekeelekvreekpkiqeqFadlkrkL 128
                 + e+++  +e+  ++r++k k++l++ ++e ++i++++++lk +L
  EFC35408.1  75 FVEVNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 556666677777777788888888877778888888888888887 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.8    0.0078       3.3      53     100 ..      13      60 ..       3      69 .. 0.59
   2 ?   10.0  10.0    0.0022      0.96      15      84 ..      34     119 ..      30     123 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0078
      APG6_N  53 eeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeer 100
                 e+   ++  e ++++++  ++     ele+e+ +l+eel++l++  ++
  EFC35408.1  13 EDNTYQITWEDQKKINNFSRINVRFNELEREITDLKEELNKLNDASDE 60 
                 444455555555556666666666666666666666666666655544 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.0022
      APG6_N  15 dkqleqaekerdaYeeflkklkkekkeeek................qdeeleeleeeleklekeeeelleeLkelekereeleael 84 
                 + +++++e+e+ +++e l+kl++ ++e                    d+ ++ l+e+ ek++k+ ++ ++e k++e++ +el+a l
  EFC35408.1  34 NVRFNELEREITDLKEELNKLNDASDEIFIsdnisyvvgelfvevnADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 66899*******************88866699*******99999988888888888899999999999999999999999988876 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   6.1    0.0055       2.4      30      95 ..      28     119 ..       2     129 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0055
       TMPIT  30 klqskcskeikkqkkrlkelksslkklkksvk.........................eeeeeeveelkeelkerkkvlkevesllpkk.ngl 95 
                 +  s++  + ++ ++++++lk++l+kl+ +++                         +  +e+ e++k++lk+r+k +k++e+ + +    l
  EFC35408.1  28 NNFSRINVRFNELEREITDLKEELNKLNDASDeifisdnisyvvgelfvevnadqaeKLLDERKEKVKKDLKDRQKEFKDIENKMKELkANL 119
                 33345555556666666666666666666644666666667777777777766655456677889999999999999999999877653444 PP

>> FliD_N  Flagellar hook-associated protein 2 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   1.2      0.11        48      18      60 ..      11      54 ..       1      82 [. 0.58
   2 ?    8.2   1.6    0.0096       4.1      20      51 ..      88     119 ..      77     132 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.11
                XXXXXXXXXXXXXXXXHHHHHHHHHHHHHHHHHHHHHXX.GGGG CS
      FliD_N 18 akldkleqkktklewkqsayrelnsklsnlksalsalsk.sstf 60
                ++ d+ +q   + ++k++ ++ +n  +++l+ ++++l++  +++
  EFC35408.1 11 TTEDNTYQITWEDQKKINNFSRINVRFNELEREITDLKEeLNKL 54
                44555556666677777788888888888887775553222222 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0096
                 XXXXXXXXXXXXXXHHHHHHHHHHHHHHHHHH CS
      FliD_N  20 ldkleqkktklewkqsayrelnsklsnlksal 51 
                  ++ e+ k++l+ +q++++++++k+++lk +l
  EFC35408.1  88 DERKEKVKKDLKDRQKEFKDIENKMKELKANL 119
                 4457788999******************9976 PP

>> SseC  Secretion system effector C (SseC) like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1       2.3   9.7e+02     272     295 ..      37      60 ..      20      64 .. 0.57
   2 ?    8.5   2.2    0.0032       1.3      11      51 ..      77     114 ..      68     120 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 2.3
        SseC 272 leqlqkvldeaaeeikellesiqe 295
                 + +l+  +  ++ee+ +l ++++e
  EFC35408.1  37 FNELEREITDLKEELNKLNDASDE 60 
                 344455555555555555555555 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0032
        SseC  11 kaaedsleskqkllkelqekqeklrqeqveeireqikkaee 51 
                 +    +++ + kll+e +ek +k+++++++e++  ++k++e
  EFC35408.1  77 E---VNADQAEKLLDERKEKVKKDLKDRQKEFKDIENKMKE 114
                 3...4556667899999999999999999999999999944 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2458  (0.137096); expected 358.6 (0.02)
Passed bias filter:                      750  (0.0418317); expected 358.6 (0.02)
Passed Vit filter:                       124  (0.00691617); expected 17.9 (0.001)
Passed Fwd filter:                        45  (0.0025099); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              42  [number of targets reported over threshold]
# CPU time: 0.70u 0.37s 00:00:01.06 Elapsed: 00:00:00.55
# Mc/sec: 731.78
//
Query:       EFC35409.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00025   21.3   0.1    0.00052   20.3   0.1    1.4  1  Calpain_III  Calpain large subunit, domain III


Domain annotation for each model (and alignments):
>> Calpain_III  Calpain large subunit, domain III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.1   2.9e-08   0.00052       2      34 ..      35      65 ..      34      93 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 2.9e-08
  Calpain_III  2 eWvkgstAGGcrnkketfwkNPqfrleleeeed 34
                 +W++  t+GG+ n+ +tf  NPq+ ++l+++ +
   EFC35409.1 35 SWTS-NTCGGSCNQINTFRLNPQYLISLPNT-N 65
                 6855.578999999**************993.2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       556  (0.0310112); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1228.06
//
Query:       EFC35410.1  [L=743]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      4e-37  126.2 292.6    0.00014   22.1   8.8   16.3 16  EGF_2         EGF-like domain
      1e-14   54.2 173.1      0.052   13.6   3.7   15.5 15  EGF_Tenascin  Tenascin EGF domain
    1.4e-07   31.7 218.0       0.51   10.7   4.3   15.9 16  EB            EB module


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2  11.4   0.00053       3.1       5      32 .]      20      45 ..      14      45 .. 0.90
   2 !   14.4  13.9   6.2e-06     0.037       5      32 .]      68      93 ..      62      93 .. 0.90
   3 !   13.2  12.9   1.5e-05     0.089       3      32 .]     112     141 ..     110     141 .. 0.89
   4 !   17.4  11.1   7.1e-07    0.0043       5      32 .]     164     189 ..     161     189 .. 0.93
   5 !   12.8   9.6   1.9e-05      0.12       5      32 .]     210     235 ..     206     235 .. 0.92
   6 !   16.2   9.2   1.7e-06      0.01       5      32 .]     257     282 ..     253     282 .. 0.94
   7 !   17.0   9.2   9.4e-07    0.0056       5      32 .]     303     328 ..     299     328 .. 0.93
   8 !   15.6  12.3   2.6e-06     0.016       5      32 .]     351     376 ..     345     376 .. 0.91
   9 !   14.4  12.3   6.3e-06     0.038       5      32 .]     399     424 ..     393     424 .. 0.91
  10 !   12.4  12.6   2.6e-05      0.16       5      32 .]     447     472 ..     441     472 .. 0.90
  11 !   22.1   8.8   2.3e-08   0.00014       5      32 .]     495     520 ..     491     520 .. 0.94
  12 !   14.4  12.3   6.3e-06     0.038       5      32 .]     543     568 ..     537     568 .. 0.91
  13 !    9.8  11.7   0.00017         1       5      32 .]     590     615 ..     584     615 .. 0.89
  14 !   18.6   9.7   2.9e-07    0.0018       5      32 .]     636     661 ..     632     661 .. 0.93
  15 !   14.4  12.3   6.3e-06     0.038       5      32 .]     684     709 ..     678     709 .. 0.91
  16 ?    2.1   3.4     0.045   2.7e+02       5      15 ..     732     742 ..     726     743 .] 0.80

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00053
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyqGktC 32
                +++C g+GtC    G C C  g  G +C
  EFC35410.1 20 ESNCYGNGTCL--DGLCICVEGMNGTYC 45
                678*******9..9************** PP

  == domain 2  score: 14.4 bits;  conditional E-value: 6.2e-06
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyqGktC 32
                +++C g+GtCv  +G C C+s+  G +C
  EFC35410.1 68 ENNCYGNGTCV--NGICICNSNVNGTYC 93
                689********..*************** PP

  == domain 3  score: 13.2 bits;  conditional E-value: 1.5e-05
       EGF_2   3 as..deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +s  +++C g+GtC+  +G C C+++  G  C
  EFC35410.1 112 SSieENTCYGNGTCI--NGICICNTNVNGTFC 141
                 5556899********..*************99 PP

  == domain 4  score: 17.4 bits;  conditional E-value: 7.1e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtC+  +G+C C+s+  G +C
  EFC35410.1 164 ENNCYGNGTCI--NGVCACNSNVNGTYC 189
                 678********..*************** PP

  == domain 5  score: 12.8 bits;  conditional E-value: 1.9e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtC+   G C+C  +  G  C
  EFC35410.1 210 ENNCYGNGTCI--DGICVCYGSANGTFC 235
                 688********..*************99 PP

  == domain 6  score: 16.2 bits;  conditional E-value: 1.7e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtC+  +G+C Cd g  G +C
  EFC35410.1 257 ENTCYGNGTCI--NGVCNCDVGVNGTYC 282
                 689********..*************** PP

  == domain 7  score: 17.0 bits;  conditional E-value: 9.4e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtC    G+C C+s+  G +C
  EFC35410.1 303 ENNCYGNGTCL--SGVCICNSNINGTYC 328
                 688********..9************** PP

  == domain 8  score: 15.6 bits;  conditional E-value: 2.6e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtC   +G C+C+s+  G +C
  EFC35410.1 351 ENNCYGNGTCL--NGICVCKSNINGTYC 376
                 678********..*************** PP

  == domain 9  score: 14.4 bits;  conditional E-value: 6.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtCv  +G C C+s+  G  C
  EFC35410.1 399 ENTCYGNGTCV--NGICICNSNVNGTFC 424
                 689********..**************9 PP

  == domain 10  score: 12.4 bits;  conditional E-value: 2.6e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C g+GtCv  +G C C+++  G  C
  EFC35410.1 447 ENSCYGNGTCV--NGICICNTNVNGTFC 472
                 678********..*************99 PP

  == domain 11  score: 22.1 bits;  conditional E-value: 2.3e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++iC g+GtC+  +G C+C+s+  G +C
  EFC35410.1 495 ENICYGNGTCI--NGICVCNSNINGTYC 520
                 79*********..*************** PP

  == domain 12  score: 14.4 bits;  conditional E-value: 6.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtCv  +G C C+s+  G  C
  EFC35410.1 543 ENTCYGNGTCV--NGICICNSNVNGTFC 568
                 689********..**************9 PP

  == domain 13  score: 9.8 bits;  conditional E-value: 0.00017
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtC   +G C+C ++  G  C
  EFC35410.1 590 ENNCYGNGTCM--NGICVCITNVNGTFC 615
                 689*******9..9************99 PP

  == domain 14  score: 18.6 bits;  conditional E-value: 2.9e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtC   +G+C C+s+  G +C
  EFC35410.1 636 ENNCYGNGTCL--NGVCICNSNINGTYC 661
                 688********..*************** PP

  == domain 15  score: 14.4 bits;  conditional E-value: 6.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C g+GtCv  +G C C+s+  G  C
  EFC35410.1 684 ENTCYGNGTCV--NGICICNSNVNGTFC 709
                 689********..**************9 PP

  == domain 16  score: 2.1 bits;  conditional E-value: 0.045
       EGF_2   5 deiCgghGtCv 15 
                 ++ C g+GtCv
  EFC35410.1 732 ENSCYGNGTCV 742
                 678*******8 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   4.3    0.0006       3.6       6      25 ..      23      42 ..      22      46 .. 0.79
   2 !   12.9   4.8   1.4e-05     0.085       6      28 ..      71      93 ..      70      94 .. 0.90
   3 !   10.2   2.4   9.9e-05      0.59       6      28 ..     119     141 ..     118     142 .. 0.87
   4 !    7.6   4.5   0.00067         4       6      28 ..     167     189 ..     166     190 .. 0.90
   5 !    5.3   6.0    0.0034        20       6      21 ..     213     228 ..     212     236 .. 0.80
   6 ?    3.0   6.7     0.019   1.1e+02       6      28 ..     260     282 ..     259     283 .. 0.85
   7 !    9.2   4.8   0.00021       1.3       6      28 ..     306     328 ..     305     329 .. 0.90
   8 !    8.6   3.3   0.00032       1.9       6      28 ..     354     376 ..     353     377 .. 0.90
   9 !   13.6   3.7   8.7e-06     0.052       6      28 ..     402     424 ..     401     425 .. 0.89
  10 !   10.7   3.8   7.1e-05      0.43       6      28 ..     450     472 ..     449     473 .. 0.87
  11 !    9.1   4.8   0.00023       1.4       6      28 ..     498     520 ..     497     521 .. 0.90
  12 !   13.6   3.7   8.7e-06     0.052       6      28 ..     546     568 ..     545     569 .. 0.89
  13 !    4.6   2.8    0.0058        35       6      26 ..     593     613 ..     592     616 .. 0.81
  14 !   11.4   3.6   4.4e-05      0.26       6      28 ..     639     661 ..     638     662 .. 0.90
  15 !   13.6   3.7   8.7e-06     0.052       6      28 ..     687     709 ..     686     710 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0006
  EGF_Tenascin  6 CssRGvCvDGqCiCDsEYsG 25
                  C   G C DG CiC     G
    EFC35410.1 23 CYGNGTCLDGLCICVEGMNG 42
                  7889**********765555 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 1.4e-05
  EGF_Tenascin  6 CssRGvCvDGqCiCDsEYsGDDC 28
                  C   G Cv+G CiC+s+  G  C
    EFC35410.1 71 CYGNGTCVNGICICNSNVNGTYC 93
                  7889*************999888 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 9.9e-05
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G C++G CiC+ +  G  C
    EFC35410.1 119 CYGNGTCINGICICNTNVNGTFC 141
                   8889**********999888766 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.00067
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G C++G C C+s+  G  C
    EFC35410.1 167 CYGNGTCINGVCACNSNVNGTYC 189
                   7889*************999888 PP

  == domain 5  score: 5.3 bits;  conditional E-value: 0.0034
  EGF_Tenascin   6 CssRGvCvDGqCiCDs 21 
                   C   G C+DG C+C  
    EFC35410.1 213 CYGNGTCIDGICVCYG 228
                   7889**********65 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.019
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G C++G C CD    G  C
    EFC35410.1 260 CYGNGTCINGVCNCDVGVNGTYC 282
                   8889***********88777666 PP

  == domain 7  score: 9.2 bits;  conditional E-value: 0.00021
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G C  G CiC+s+  G  C
    EFC35410.1 306 CYGNGTCLSGVCICNSNINGTYC 328
                   7889*************999888 PP

  == domain 8  score: 8.6 bits;  conditional E-value: 0.00032
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G C +G C+C s+  G  C
    EFC35410.1 354 CYGNGTCLNGICVCKSNINGTYC 376
                   7889*************999887 PP

  == domain 9  score: 13.6 bits;  conditional E-value: 8.7e-06
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G Cv+G CiC+s+  G  C
    EFC35410.1 402 CYGNGTCVNGICICNSNVNGTFC 424
                   8889************9999777 PP

  == domain 10  score: 10.7 bits;  conditional E-value: 7.1e-05
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G Cv+G CiC+ +  G  C
    EFC35410.1 450 CYGNGTCVNGICICNTNVNGTFC 472
                   8889**********999888766 PP

  == domain 11  score: 9.1 bits;  conditional E-value: 0.00023
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G C++G C+C+s+  G  C
    EFC35410.1 498 CYGNGTCINGICVCNSNINGTYC 520
                   7788*************999888 PP

  == domain 12  score: 13.6 bits;  conditional E-value: 8.7e-06
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G Cv+G CiC+s+  G  C
    EFC35410.1 546 CYGNGTCVNGICICNSNVNGTFC 568
                   8889************9999777 PP

  == domain 13  score: 4.6 bits;  conditional E-value: 0.0058
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGD 26 
                   C   G C++G C+C  +  G 
    EFC35410.1 593 CYGNGTCMNGICVCITNVNGT 613
                   7889**********8776665 PP

  == domain 14  score: 11.4 bits;  conditional E-value: 4.4e-05
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G C +G CiC+s+  G  C
    EFC35410.1 639 CYGNGTCLNGVCICNSNINGTYC 661
                   7889*************999888 PP

  == domain 15  score: 13.6 bits;  conditional E-value: 8.7e-06
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsGDDC 28 
                   C   G Cv+G CiC+s+  G  C
    EFC35410.1 687 CYGNGTCVNGICICNSNVNGTFC 709
                   8889************9999777 PP

>> EB  EB module
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.7   4.3   8.6e-05      0.51      24      46 ..      19      41 ..      13      47 .. 0.88
   2 !    7.2   9.3     0.001         6      24      44 ..      67      87 ..      40      96 .. 0.77
   3 !    8.2   7.8   0.00051       3.1      24      44 ..     115     135 ..      86     145 .. 0.71
   4 !    6.2   8.7    0.0022        13      24      44 ..     163     183 ..     153     196 .. 0.86
   5 !    6.4   7.7    0.0019        11      22      41 ..     204     226 ..     183     236 .. 0.72
   6 !    5.7   8.8     0.003        18      25      45 ..     257     277 ..     235     282 .. 0.84
   7 !    4.8   9.0     0.006        36      23      44 ..     301     322 ..     277     333 .. 0.77
   8 !    7.4   8.6   0.00092       5.5      25      44 ..     351     370 ..     321     379 .. 0.75
   9 !    9.0   7.6   0.00028       1.7      25      44 ..     399     418 ..     370     425 .. 0.78
  10 !    7.8   6.8   0.00066         4      26      44 ..     448     466 ..     439     475 .. 0.86
  11 !    6.9   7.9    0.0013       7.8      25      44 ..     495     514 ..     468     524 .. 0.83
  12 !    8.8   8.0   0.00032       1.9      25      44 ..     543     562 ..     513     572 .. 0.76
  13 !    6.2   7.8    0.0022        13      25      43 ..     590     608 ..     568     618 .. 0.86
  14 !    5.8   8.4    0.0029        17      24      44 ..     635     655 ..     610     662 .. 0.85
  15 !    8.9   8.0   0.00031       1.9      25      44 ..     684     703 ..     653     711 .. 0.74
  16 ?   -3.5   1.1       2.2   1.3e+04      26      35 ..     733     742 ..     726     743 .] 0.63

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 8.6e-05
          EB 24 vseqCsggsvCkagiCvCpegkt 46
                ++++C g+ +C +g C+C eg+ 
  EFC35410.1 19 EESNCYGNGTCLDGLCICVEGMN 41
                6789****************985 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.001
          EB 24 vseqCsggsvCkagiCvCpeg 44
                ++++C g+ +C++giC+C+++
  EFC35410.1 67 EENNCYGNGTCVNGICICNSN 87
                4568**************986 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00051
          EB  24 vseqCsggsvCkagiCvCpeg 44 
                 ++++C g+ +C +giC+C+ +
  EFC35410.1 115 EENTCYGNGTCINGICICNTN 135
                 5678**************875 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0022
          EB  24 vseqCsggsvCkagiCvCpeg 44 
                 ++++C g+ +C +g+C+C+++
  EFC35410.1 163 DENNCYGNGTCINGVCACNSN 183
                 5678**************986 PP

  == domain 5  score: 6.4 bits;  conditional E-value: 0.0019
          EB  22 C...evseqCsggsvCkagiCvC 41 
                 C   e++++C g+ +C +giCvC
  EFC35410.1 204 CgftEDENNCYGNGTCIDGICVC 226
                 655345667************** PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.003
          EB  25 seqCsggsvCkagiCvCpegk 45 
                 +++C g+ +C +g+C C+ g 
  EFC35410.1 257 ENTCYGNGTCINGVCNCDVGV 277
                 568**************9885 PP

  == domain 7  score: 4.8 bits;  conditional E-value: 0.006
          EB  23 evseqCsggsvCkagiCvCpeg 44 
                 e++++C g+ +C +g+C+C+++
  EFC35410.1 301 EDENNCYGNGTCLSGVCICNSN 322
                 45678**************986 PP

  == domain 8  score: 7.4 bits;  conditional E-value: 0.00092
          EB  25 seqCsggsvCkagiCvCpeg 44 
                 +++C g+ +C +giCvC+++
  EFC35410.1 351 ENNCYGNGTCLNGICVCKSN 370
                 567**************986 PP

  == domain 9  score: 9.0 bits;  conditional E-value: 0.00028
          EB  25 seqCsggsvCkagiCvCpeg 44 
                 +++C g+ +C++giC+C+++
  EFC35410.1 399 ENTCYGNGTCVNGICICNSN 418
                 568**************986 PP

  == domain 10  score: 7.8 bits;  conditional E-value: 0.00066
          EB  26 eqCsggsvCkagiCvCpeg 44 
                 + C g+ +C++giC+C+ +
  EFC35410.1 448 NSCYGNGTCVNGICICNTN 466
                 57**************875 PP

  == domain 11  score: 6.9 bits;  conditional E-value: 0.0013
          EB  25 seqCsggsvCkagiCvCpeg 44 
                 ++ C g+ +C +giCvC+++
  EFC35410.1 495 ENICYGNGTCINGICVCNSN 514
                 345**************986 PP

  == domain 12  score: 8.8 bits;  conditional E-value: 0.00032
          EB  25 seqCsggsvCkagiCvCpeg 44 
                 +++C g+ +C++giC+C+++
  EFC35410.1 543 ENTCYGNGTCVNGICICNSN 562
                 568**************986 PP

  == domain 13  score: 6.2 bits;  conditional E-value: 0.0022
          EB  25 seqCsggsvCkagiCvCpe 43 
                 +++C g+ +C +giCvC  
  EFC35410.1 590 ENNCYGNGTCMNGICVCIT 608
                 568**************75 PP

  == domain 14  score: 5.8 bits;  conditional E-value: 0.0029
          EB  24 vseqCsggsvCkagiCvCpeg 44 
                 ++++C g+ +C +g+C+C+++
  EFC35410.1 635 DENNCYGNGTCLNGVCICNSN 655
                 5678**************986 PP

  == domain 15  score: 8.9 bits;  conditional E-value: 0.00031
          EB  25 seqCsggsvCkagiCvCpeg 44 
                 +++C g+ +C++giC+C+++
  EFC35410.1 684 ENTCYGNGTCVNGICICNSN 703
                 568**************986 PP

  == domain 16  score: -3.5 bits;  conditional E-value: 2.2
          EB  26 eqCsggsvCk 35 
                 + C g+ +C+
  EFC35410.1 733 NSCYGNGTCV 742
                 3466666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (743 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       308  (0.0171789); expected 358.6 (0.02)
Passed bias filter:                       83  (0.00462937); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.81u 0.31s 00:00:01.12 Elapsed: 00:00:00.54
# Mc/sec: 4150.60
//
Query:       EFC35411.1  [L=209]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.012   15.9   0.2      0.015   15.5   0.2    1.2  1  MipA      MltA-interacting protein MipA
      0.026   14.3   0.1       0.59   10.0   0.0    2.4  2  DUF4812   Domain of unknown function (DUF4812)


Domain annotation for each model (and alignments):
>> MipA  MltA-interacting protein MipA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.5   0.2   1.7e-06     0.015     108     175 ..      64     131 ..      20     140 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.7e-06
        MipA 108 sasfsl.sgrwtlspgaglsyasskyndyyYGVsaaeaaasglpaYkagaglssvglglgasyrplten 175
                 + +f +  ++w+l +  ++s   + +++ yY V+ +   ++g+++Y+ ++ ++s++   +++y+ lt  
  EFC35411.1  64 AIQFFAdVEGWQLNVDSSFSRVKKGLTKAYYIVDRSKLKRNGFSSYDIKSYIDSISSHDEYTYN-LTTA 131
                 3445557789****************************************99999999999995.8854 PP

>> DUF4812  Domain of unknown function (DUF4812)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   6.5e-05      0.59      11      32 ..      52      73 ..      47      78 .. 0.87
   2 ?    1.6   0.0     0.027   2.5e+02       4      25 ..     181     203 ..     178     208 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 6.5e-05
     DUF4812 11 akksyvietLvPPFslwkgtka 32
                 kksy+i+tL P  +++++ ++
  EFC35411.1 52 NKKSYDINTLKPAIQFFADVEG 73
                69************99998765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.027
     DUF4812   4 Pkprtpya.kksyvietLvPPFs 25 
                 P p +py   k+y+  tL   F 
  EFC35411.1 181 PTPIEPYCgEKKYCPMTLFNLFY 203
                 88999**999****999987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       566  (0.031569); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1317.08
//
Query:       EFC35412.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.6e-09   36.7   0.0    1.1e-05   25.3   0.0    2.6  2  NHL          NHL repeat
  ------ inclusion threshold ------
       0.12   12.7   0.1       0.95    9.8   0.0    2.4  2  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.3   0.0   1.2e-09   1.1e-05       1      28 []     247     275 ..     247     275 .. 0.98
   2 !    8.9   0.0   0.00018       1.6       4      28 .]     293     318 ..     291     318 .. 0.92

  Alignments for each domain:
  == domain 1  score: 25.3 bits;  conditional E-value: 1.2e-09
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 f++P G+a+d ++G i+ +D+ n r++vF
  EFC35412.1 247 FSQPLGLAIDrKGGKIFLSDYDNKRIVVF 275
                 89**************************9 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00018
                 EEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   4 PhGvavd.snGdiyVaDsenhrvqvF 28 
                 P G+  d  +G +y++D   h++++F
  EFC35412.1 293 PYGLDFDeRTGLLYITDQQDHSIRIF 318
                 67999999****************99 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.19   1.7e+03      53      87 ..      76     107 ..      68     112 .. 0.78
   2 ?    9.8   0.0   0.00011      0.95      48      88 ..     165     205 ..     136     209 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.19
  ANAPC4_WD40  53 Lavaysdgevrlldaesgkvvhslsvksekavtcl 87 
                  L++  s+++v+++d  + + + ++ v+    vtcl
   EFC35412.1  76 LCI-SSNSAVKFFDLTNHEYLGAFFVEGG--VTCL 107
                  444.478899*****99999999988877..8887 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00011
  ANAPC4_WD40  48 pdgklLavaysdgevrlldaesgkvvhslsvksekavtclg 88 
                  ++ +l+ ++ s+g++ ++d  +gkv+++l+ ++ k+vt + 
   EFC35412.1 165 NQKQLFRFSDSKGAMDIIDTVNGKVIKELKLEKIKTVTDII 205
                  4567888999*********************9999888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       639  (0.0356406); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1978.43
//
Query:       EFC35413.1  [L=161]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-48  162.7   0.8    2.2e-17   62.5   0.0    4.3  5  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.5   0.0   1.2e-21   2.2e-17       1      46 [.       6      51 ..       6      54 .. 0.96
   2 !   46.3   0.0   1.4e-16   2.5e-12       1      49 []      31      79 ..      31      79 .. 0.99
   3 !   32.5   0.1   2.8e-12   5.1e-08       1      36 [.      56      91 ..      56      93 .. 0.95
   4 !   35.4   0.0   3.5e-13   6.4e-09       1      45 [.      81     125 ..      81     128 .. 0.94
   5 !    4.9   0.0    0.0012        22      23      39 ..     126     142 ..     124     158 .. 0.73

  Alignments for each domain:
  == domain 1  score: 62.5 bits;  conditional E-value: 1.2e-21
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46
                D+E+vl+avk+ g+a++y+seeLk+D+e vl+Avkq+gta++y+ +
  EFC35413.1  6 DKELVLQAVKNSGLAIYYASEELKRDRETVLEAVKQDGTAYNYVAP 51
                9******************************************966 PP

  == domain 2  score: 46.3 bits;  conditional E-value: 1.4e-16
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                DrE vleavk++g a++y+ + +++Dkei+  Av++++++++ ase+L+
  EFC35413.1 31 DRETVLEAVKQDGTAYNYVAPHFSSDKEIISLAVQRDSNFFNLASESLK 79
                9**********************************************97 PP

  == domain 3  score: 32.5 bits;  conditional E-value: 2.8e-12
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36
                D+Ei+  av+++++ ++ +se+LknD e+v+ +v  
  EFC35413.1 56 DKEIISLAVQRDSNFFNLASESLKNDYEFVMDIVST 91
                9******************************99976 PP

  == domain 4  score: 35.4 bits;  conditional E-value: 3.5e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 D E+v+ +v++ g++lk+l+e L nD+ i l+A+ +ng ++++ +
  EFC35413.1  81 DYEFVMDIVSTRGMILKFLPETLMNDRAINLAAILNNGRVIEFSP 125
                 669*************************************99966 PP

  == domain 5  score: 4.9 bits;  conditional E-value: 0.0012
     DUF4116  23 LknDkeivlkAvkqngt 39 
                 +k+D ei+ +Avk  ++
  EFC35413.1 126 FKHDPEILNQAVKVVPY 142
                 79999999999997664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 934.10
//
Query:       EFC35414.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.9e-09   35.9  15.8     0.0001   23.0   0.3    6.1  6  WD40         WD domain, G-beta repeat
    0.00066   19.9   6.4        1.4    9.3   0.1    4.9  6  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.2    0.0035        32      17      38 .]      66      90 ..      28      90 .. 0.69
   2 !    5.9   0.3    0.0029        26      15      37 ..     116     132 ..     104     133 .. 0.86
   3 !    7.2   0.1    0.0011        10      12      38 .]     171     198 ..     161     198 .. 0.84
   4 ?   -0.0   0.0      0.22   1.9e+03       3      35 ..     206     241 ..     205     244 .. 0.58
   5 !   23.0   0.3   1.2e-08    0.0001      10      38 .]     259     289 ..     249     289 .. 0.84
   6 ?   -1.5   0.0      0.64   5.8e+03      12      35 ..     329     353 ..     318     356 .. 0.60

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0035
                E...EETTSSEEE.EEETTSEEEEEE CS
        WD40 17 a...fspdgawla.sGsdDgtvriWd 38
                     +++ + l+ s++ D+ +r++d
  EFC35414.1 66 HilwSHRNESILLsSCH-DNVLRFFD 90
                24433344444551556.*****998 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0029
                 EEEEETTSSEEEEEETTSEEEEE CS
        WD40  15 slafspdgawlasGsdDgtvriW 37 
                 sl       w+++G+ D +++++
  EFC35414.1 116 SL------EWIITGGIDSSIKLY 132
                 56......89***********98 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.0011
                 SEEEEEEETTSSE.EEEEETTSEEEEEE CS
        WD40  12 svtslafspdgaw.lasGsdDgtvriWd 38 
                 ++++++++ ++++ +++ ++Dg v +Wd
  EFC35414.1 171 PIHDIQWNTHSPMqFLTTDRDGFVCLWD 198
                 48999888888889668899*******9 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 0.22
                 EEEEEESS.SSEEEEE....EETTSSEEEEEETTSEEE CS
        WD40   3 clrtltGH.ssvtsla....fspdgawlasGsdDgtvr 35 
                 c+++++ H +  ++l+      +++++ + G+ D++++
  EFC35414.1 206 CVKSFRIHnKT-CALKmdlnIFDENSLAL-GCFDNSLM 241
                 88899999533.33333343666666666.65588876 PP

  == domain 5  score: 23.0 bits;  conditional E-value: 1.2e-08
                 S.SSEEEEEEETTSSEEE.EEETTSEEEEEE CS
        WD40  10 H.ssvtslafspdgawla.sGsdDgtvriWd 38 
                 H s +ts ++sp+ + l+ ++s D+t+riWd
  EFC35414.1 259 HySQITSTQWSPHTQHLVaTSSTDRTLRIWD 289
                 8788************8637788*******9 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 0.64
                 SEEEEEEETTSSE........EEEEETTSEEE CS
        WD40  12 svtslafspdgaw........lasGsdDgtvr 35 
                 +v+++      aw         +++  D+ v+
  EFC35414.1 329 WVNDI------AWnihevglmALCCN-DQLVK 353
                 47888......555555554323555.77776 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0         1   9.4e+03      43      59 ..      13      30 ..      12      31 .. 0.73
   2 !    9.3   0.1   0.00015       1.4      42      90 ..      65     113 ..      55     115 .. 0.84
   3 ?    0.6   0.1     0.078     7e+02      51      82 ..     118     151 ..     104     187 .. 0.51
   4 ?    0.0   0.0      0.12   1.1e+03      49      71 ..     227     249 ..     195     258 .. 0.85
   5 !    6.0   0.0    0.0017        15      37      78 ..     259     301 ..     232     314 .. 0.79
   6 ?    2.9   0.1     0.016   1.4e+02      28      67 ..     317     357 ..     312     360 .] 0.78

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1
  ANAPC4_WD40 43 sLaWkp.dgklLavaysd 59
                 sL+W+p  ++ Lava+s+
   EFC35414.1 13 SLEWSPfIENQLAVATSN 30
                 678887347889998886 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00015
  ANAPC4_WD40  42 rsLaWkp.dgklLavaysdgevrlldaesgkvvhslsvksekavtclgWg 90 
                  +++ W++ ++++L  +++d+ +r++d ++++++     +++ +++ l+W 
   EFC35414.1  65 QHILWSHrNESILLSSCHDNVLRFFDTQNTDCMYREWFDTQ-SISNLDWD 113
                  56778642899*********************999888877.59999996 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.078
  ANAPC4_WD40  51 klLavaysdgevrlldae..sgkvvhslsvksek 82 
                  + +  +  d++++l++ +  s + ++++++k+++
   EFC35414.1 118 EWIITGGIDSSIKLYHENqdSNESLQTFHTKKHE 151
                  5566666666677766441134455555555554 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.12
  ANAPC4_WD40  49 dgklLavaysdgevrlldaesgk 71 
                  d++ La ++ d+++  +d  + k
   EFC35414.1 227 DENSLALGCFDNSLMTYDLRNVK 249
                  78899999999999988887755 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.0017
  ANAPC4_WD40  37 edsevrsLaWkpdgk.lLavaysdgevrlldaesgkvvhslsv 78 
                  + s+++s +W+p  + l a +  d ++r+ d+ + + + +++ 
   EFC35414.1 259 HYSQITSTQWSPHTQhLVATSSTDRTLRIWDMRESNNLLQFNN 301
                  56899******986515566777889*****999888777765 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.016
  ANAPC4_WD40  28 rvwtleedkedsevrsLaWkpdgk.lLavaysdgevrllda 67 
                  rv +++++k +  v+++aW+  +  l+a  ++d  v+ +++
   EFC35414.1 317 RVSNFKNQKMEDWVNDIAWNIHEVgLMALCCNDQLVKAYNI 357
                  6777888999999*******988526777888888877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 2128.74
//
Query:       EFC35415.1  [L=681]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (681 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       911  (0.0508115); expected 358.6 (0.02)
Passed bias filter:                      541  (0.0301746); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.50
# Mc/sec: 4067.50
//
Query:       EFC35416.1  [L=320]
Description: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   1.3e-119  399.5   8.6   1.5e-119  399.3   8.6    1.0  1  HMG-CoA_red  Hydroxymethylglutaryl-coenzyme A reductase


Domain annotation for each model (and alignments):
>> HMG-CoA_red  Hydroxymethylglutaryl-coenzyme A reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  399.3   8.6  8.4e-124  1.5e-119      62     367 .]       1     318 [.       1     318 [. 0.99

  Alignments for each domain:
  == domain 1  score: 399.3 bits;  conditional E-value: 8.4e-124
                  E---STTHHHHHHHHHHHHHHT..T-B.EEEE----EEEEEEEE.--S-HHHHHHHHHTHHHHHHHHHHCSHHCCT-EEEEEEEEE-SSEEEEEEEEE CS
  HMG-CoA_red  62 mAteEgslvAsasrgakaines..gGvkttvlkdgmtraqvvllesvedaaelkkwiekkeeleelanaaestsrggglkdievvlagrlvvlrlkvd 157
                  mAt Eg+lvAs++rg+ka+++s  gGv++++l+dgmtr++vv ++++++ +elk++i++ e+++el++ ++s sr+++l +++v +agr ++lr+k++
   EFC35416.1   1 MATVEGCLVASTHRGCKALSSSfeGGVNSVILSDGMTRGPVVQFANTKRCNELKQFIDNPENFKELCRVFNSDSRFARLLEVKVGIAGRKAFLRFKCR 98 
                  9******************99888************************************************************************** PP

                  -TTC--HHHHHHHHHHHHHHHH.HHHTSEEEEEEE-S--GGGEEEEEEEEEHHHH..-SSTTHHHHHHHHHHHHHHHHHH-HHHH....HHHHHHH.. CS
  HMG-CoA_red 158 tgDAmGaNmvnkateaaaelie.eefgeeellsilsNlctdkkasainaiegrgksvvaeatigeevvekilkasaealvdlnra.n.igtankGi.g 251
                  tgDAmG+Nm++kat++a+++++ e+f+++++ls+++N+ctdkk+sa+n+iegrgksvv++ati+++vv+++lk++++++v+ln++ n ig+a++G+ g
   EFC35416.1  99 TGDAMGMNMISKATQKALKFLKnEHFQDMDILSLSGNYCTDKKPSAMNWIEGRGKSVVVDATIPKDVVKNVLKTTVDEIVSLNISkNlIGSAMAGSvG 196
                  *********************9566************************************************************************* PP

                  ......HHHHHHHHHHTT--HHHHHHHHHHHTTSEEETTTEEEEEEEEE.----SBSHHHHH-HHHHHHHHTT---HH.........HHHHHHHHHHH CS
  HMG-CoA_red 252 gfnahaaNgiaAvflAtGqDlaaveesshaiaaleevedgdlygsvtlPsleVGtvGGgtklppqaellkllgvkgak......nakeLaeiiaavgL 343
                  gfnahaaN+++A+flAtGqD+a+++ess++++++e++++gdly+svt+Ps+eVGtvGGgt+l +q+++lk++gv+ga+      na++La+ +a++++
   EFC35416.1 197 GFNAHAANIVTAIFLATGQDAAQNVESSNCMTIMEKTDNGDLYVSVTMPSIEVGTVGGGTHLDAQKTCLKIIGVAGANqenpgqNAQTLAKCVASTVM 294
                  ************************************************************************************************** PP

                  HHHHHHHHHHT-----HHHHHHHH CS
  HMG-CoA_red 344 AqelsalrALaaeglqkgHmklhr 367
                  A+els+++ALaa++l+++H +++r
   EFC35416.1 295 AGELSLMAALAADHLVSAHIAHNR 318
                  *********************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       653  (0.0364214); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2036.22
//
Query:       EFC35417.1  [L=540]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-52  179.3  19.8    4.7e-30  104.9   3.4    2.1  2  Sugar_tr  Sugar (and other) transporter
    3.7e-21   75.4  32.6    1.7e-16   60.1  16.0    2.5  2  MFS_1     Major Facilitator Superfamily
    0.00017   21.0   6.9    0.00049   19.5   2.1    2.3  2  MFS_4     Uncharacterised MFS-type transporter YbfB
     0.0002   20.0   8.5     0.0012   17.3   2.3    2.2  2  TRI12     Fungal trichothecene efflux pump (TRI12)
  ------ inclusion threshold ------
      0.062   13.7   0.1       0.26   11.7   0.1    2.1  1  TMEM70    Assembly, mitochondrial proton-transport ATP synth 
       0.64   10.1   4.1        1.2    9.3   2.0    2.3  2  DUF2933   Protein of unknown function (DUF2933)


Domain annotation for each model (and alignments):
>> Sugar_tr  Sugar (and other) transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.9   3.4   1.6e-33   4.7e-30      49     227 ..       1     173 [.       1     197 [. 0.82
   2 !   80.3   8.6   4.5e-26   1.4e-22     232     440 ..     270     483 ..     236     487 .. 0.87

  Alignments for each domain:
  == domain 1  score: 104.9 bits;  conditional E-value: 1.6e-33
                 HHHHHTHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHH-TTTTSS-TGGGGGHHHHHHHHHHHHHHHHHHHHTTS-.SCCHHHHHHHHHHH CS
    Sugar_tr  49 glivsiflvGaiiGslfagllgdrfGRkkslliaavlfvigavlqaaakgknsvevlivgRvlvGigvGlasvlvPmyisEiAp.kklRgalvslyqla 146
                 gl++s+ ++G+++G+lfa++ g ++GRk s++ ++++++ig++  aa+    ++  liv R ++G+g G++++++++y+ E+ p +k+ g l+s+++l+
  EFC35417.1   1 GLFASSIFIGGLFGCLFAMFTGSVLGRKLSIILSCLISIIGSIGAAASY---QYSTLIVFRCILGFGSGIVTAVSSVYVVELMPfPKYMGLLGSMFNLG 96 
                 799**********************************************...9*****************************9868999********** PP

                 HHHHHHHHHHHHHHHHTSS-TTHHHHHHHCCHHHHHHHHHHG.GGS---HHHHHHTT-HHHHHHHHHHHHHCHHHHHHHHHH CS
    Sugar_tr 147 itfGilvaaifglglnktsnadgwrillglqlvpallllill.lflPESPrylvekgkeeeakevlaklrgeedadrelaee 227
                 i++G   ++ fg+++ ++s+   wr   ++  ++ + l++l+ + +PESP +   +g + + +e l++ + +++ d++ + +
  EFC35417.1  97 ISLGTCWGYAFGAIFVRSSE--MWRAVHAFHNLFIIPLFVLVvFIIPESPLFI--HGGHHDHEEELKQ-KHQQKMDESKVGI 173
                 ***************99999..899988887766666666552778****774..4444444444444.2334444444444 PP

  == domain 2  score: 80.3 bits;  conditional E-value: 4.5e-26
                 HHHHH.....HTTHHHHSH...HHHHHHHHHHHHHHTTHHHHHHHTTTHHHHSS-THH...HHHHHHHHHHHHHHHHHHHHHHHHS-SHHHHHHHHHHH CS
    Sugar_tr 232 eaeqeeekaswkellssktvrqrlligvvlqifqqltGinaimyysptifenlglsks...llvtiivgvvnfvatfvaiflvdrfGRRtllllGaagm 327
                 +++  ++ a  k+l+ s +v ++l+i++   ++   tGi +   + p+++e +g+s++    l++++v+v++ + +f  +flvd+fGR++l+++G+++ 
  EFC35417.1 270 KKKTMSTIAACKRLFCS-KVIKALIIACWGCFAMEWTGIQSSVMFLPSLIEAAGVSDPlgqQLASLGVSVWQLFCIFPTMFLVDKFGRKPLMIFGFTVS 367
                 33322224556777777.579999999999999****************************************************************** PP

                 HHHHHHHH..HHHHTTSS...CHHHHHHHHHHHHHHHTTTTHHHHHHHHHHS...HTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHT-HHHHHHH CS
    Sugar_tr 328 aicfvilgivalllvakskaasivaivfialfialfalgwgpvpwvlvsElf...pqsvRskalaiavavnwlanflisllfpiiteaigggyvflvfa 423
                 ++  +  g ++ ++++++  +  +a+ f +l+++ f +g+g++ +vl+ E+f    ++v  ++++i++ ++w  +++ sl+f  ++   ++++  ++fa
  EFC35417.1 368 FLTDLAEGFIFQFGENGQVYKVALALLFNCLYLIGFHVGVGSLGYVLAYEVFrgeNEKVVVLGTSISTIAMWSTSIILSLFFIPVVVMTNQAVPWFIFA 466
                 ********99*******9888999****************************44447888899*******************9999999999******* PP

                 HHHHHHHHHHHHHS--S CS
    Sugar_tr 424 glavlfiifvfffvpet 440
                 g+  ++ii+    + et
  EFC35417.1 467 GFSFIGIIIYSTLLEET 483
                 *******9987777776 PP

>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.1  16.0   5.8e-20   1.7e-16      36     258 ..       2     344 ..       1     345 [. 0.77
   2 !   23.0  15.3   1.1e-08   3.3e-05       3     194 ..     298     498 ..     296     513 .. 0.70

  Alignments for each domain:
  == domain 1  score: 60.1 bits;  conditional E-value: 5.8e-20
       MFS_1  36 llltlyalgaavaslplGrlsdrfGrrrvlllglllfalglllllfa.sslwlllvlrvlqGlgagalfpagaaliadwfpk.eergraigllsagfsl 132
                 l ++  ++g +++ l++++ +  +Gr+  ++l+ l++++g  +++ a  ++ +l+v+r++ G+g+g++++++ ++++++ p  +  g+  +++++g+sl
  EFC35417.1   2 LFASSIFIGGLFGCLFAMFTGSVLGRKLSIILSCLISIIG-SIGAAAsYQYSTLIVFRCILGFGSGIVTAVSSVYVVELMPFpKYMGLLGSMFNLGISL 99 
                 56677899999999999999999*****************.555534466679****************************933344444666666666 PP

       MFS_1 133 Gailgpllgglla.sslgWravfyilaivsllafvlfllll.............peepperkrkspkeee............................. 188
                 G+  g+++g++++ ss  Wrav  ++ ++ + +fvl+++ +                           ee                             
  EFC35417.1 100 GTCWGYAFGAIFVrSSEMWRAVHAFHNLFIIPLFVLVVFIIpesplfihgghhdH-------------EEelkqkhqqkmdeskvgianqnaanptenr 185
                 666677777777744444****999999999999998888855555554444330.............3334455555666677778888888888888 PP

       MFS_1 189 ....................................................................................kgtgpaplvp..... 198
                                                                                                     k        +     
  EFC35417.1 186 pvvegntdeeqiktlphvcsayvnndaiddsevlereqdaadietqqdespideqerpklqqeqpsgeanteiempviteeppiK--------Kktmst 276
                 888888888888******************************************9999999999999999999888666655544........244445 PP

       MFS_1 199 ..awkallkdpvlw....illialllfffgfsglltllplylqevlgls.....glllaglllallalvga 258
                   a k l+ ++v+     +++ ++++ ++g+++ +++lp+ l e  g s      l ++g  +++ +l+++
  EFC35417.1 277 iaACKRLFCSKVIKaliiACWGCFAMEWTGIQSSVMFLPS-LIEAAGVSdplgqQLASLG--VSVWQLFCI 344
                 556999999999954244555555555777777*******.5*******99976666666..888887776 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 1.1e-08
       MFS_1   3 laaflsalarsilgpalplalaedlgispse.igllltlyalgaavaslplGrlsdrfGrrrvlllglllfalg.lllll.fa....sslw.lllvlrv 93 
                  ++++  +++    ++lp  l e+ g+s    ++l+  ++++ +++ ++p+++l+d+fGr++++++g+++++l+ l+ ++ f      +++ + l+l +
  EFC35417.1 298 GCFAMEWTGIQSSVMFLP-SLIEAAGVSDPLgQQLASLGVSVWQLFCIFPTMFLVDKFGRKPLMIFGFTVSFLTdLAEGFiFQfgenGQVYkVALALLF 395
                 567777788888899999.77788887766636666666***********************************8887777534465444444444444 PP

       MFS_1  94 ....lqGlgagalfpagaaliadwfpkeergraigllsa.....gfslGailgpllggllasslgWravfyilaivsllafvlfllllpeepperkrks 183
                     l G+   ++ ++g++l+ ++f + e  +++ l ++     ++s ++il   + ++++   +  ++++i+a++s++++++   ll e+ p+   k+
  EFC35417.1 396 nclyLIGFH-VGVGSLGYVLAYEVFRG-ENEKVVVLGTSistiaMWSTSIILSLFFIPVVV-MTNQAVPWFIFAGFSFIGIIIYSTLLEETSPNIIAKR 491
                 444477776.588899999999***99.444444444441233355555555555555555.44577889**********9988888877777777777 PP

       MFS_1 184 pkeeekgtgpa 194
                  + +    +++
  EFC35417.1 492 AVAK----AKK 498
                 6666....333 PP

>> MFS_4  Uncharacterised MFS-type transporter YbfB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   2.1   1.6e-07   0.00049      31     170 ..       1     137 [.       1     170 [. 0.86
   2 !    3.8   0.2    0.0095        28     142     187 ..     453     499 ..     427     510 .. 0.66

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.6e-07
       MFS_4  31 gllaaaNylGYLvGallaafalsagaeRlrllagllatvllllamaltesfaaflliRflaGvasAvvlvfgsslvlahaaaarrervgallfaGvGlG 129
                 gl a+  ++G L G l+a+f+ s    +l +  + l + +  +  a+  + +++++ R ++G +s++v  + s  v++ +   +   +++ +f    lG
  EFC35417.1   1 GLFASSIFIGGLFGCLFAMFTGSVLGRKLSIILSCLISIIGSIGAAASYQYSTLIVFRCILGFGSGIVTAVSSVYVVELMPFPKYMGLLGSMFN---LG 96 
                 6789999***************999999999999999*************************************9*999888888889999986...9* PP

       MFS_4 130 iavsgllvllllqlglsasslWlalavlsavllllvalllp 170
                 i ++    ++  + ++ +s +W a+ ++  + ++ +++l+ 
  EFC35417.1  97 ISLGTCWGYAFGAIFVRSSEMWRAVHAFHNLFIIPLFVLVV 137
                 ************************99999888887777654 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.0095
       MFS_4 142 qlglsasslWlalavlsavllllvalllpraalr.easaaaeaakae 187
                 ++ +++++ W+++a +s++ +++  +ll +++++  a+ a  +ak+e
  EFC35417.1 453 VVMTNQAVPWFIFAGFSFIGIIIYSTLLEETSPNiIAKRAVAKAKKE 499
                 344555666*************9999999443330333333333333 PP

>> TRI12  Fungal trichothecene efflux pump (TRI12)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   2.3   4.1e-07    0.0012     103     237 ..      23     159 ..       1     172 [. 0.75
   2 !    6.4   0.5   0.00082       2.5      42     119 ..     293     368 ..     268     476 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 4.1e-07
       TRI12 103 drfgrrpfvilthilglvgaivgctatkfntllaamtllgvaagpaga.splfvgelmsnktkflgllivsipv.vvtsglspy.lgqrlaiqgs..wr 196
                   +gr+  +il+ ++ ++g+i  +++ ++ tl+    +lg  +g   a s ++v elm    k++gll       + + +   y +g    ++ s  wr
  EFC35417.1  23 SVLGRKLSIILSCLISIIGSIGAAASYQYSTLIVFRCILGFGSGIVTAvSSVYVVELMPF-PKYMGLLGSMFNLgISLGTCWGYaFGAI-FVRSSemWR 119
                 5689****************************************8654389*******85.79***99755443133333334415554.444431277 PP

       TRI12 197 wifyiyiitsaiavllivvwyyppsfaqlhgkkvrkreela 237
                  +   +  +  i + ++vv+  p s   +hg +  + eel 
  EFC35417.1 120 AVHA-FHNLFIIPLFVLVVFIIPESPLFIHGGHHDHEEELK 159
                 6654.445567888889999999999999*99999999986 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.00082
       TRI12  42 vvasfaafslnvvatyfvlqasasalpnilqdvgqse..nsslfstlwttgqavsilvmgrltdrfgrrpfvilthilgl 119
                 ++a + +f+++    +  +q+s   lp +++  g s+   + l s   ++ q   i+    l d+fgr+p++i    + +
  EFC35417.1 293 IIACWGCFAME----WTGIQSSVMFLPSLIEAAGVSDplGQQLASLGVSVWQLFCIFPTMFLVDKFGRKPLMIFGFTVSF 368
                 56666666665....44689************99998334778888889999999*9999************98877665 PP

>> TMEM70  Assembly, mitochondrial proton-transport ATP synth complex
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   8.6e-05      0.26       7      80 ..     441     514 ..     436     535 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 8.6e-05
      TMEM70   7 stsllslllqPvlvlkaeksvsslvlkvaicgiigfftvltpvllHlitkkYVirlyydaetdeytavtynlll 80 
                 ++ +lsl+++Pv+v+ ++ +  ++ +  +++gii+  t+l  +   +i+k+ V +   +ae++   +  ++ + 
  EFC35417.1 441 TSIILSLFFIPVVVMTNQAVPWFIFAGFSFIGIIIYSTLLEETSPNIIAKRAVAKAKKEAEKKAISVAGVENVQ 514
                 345789**************999***********************************9999988776665554 PP

>> DUF2933  Protein of unknown function (DUF2933)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   2.0   0.00039       1.2      15      48 ..     122     157 ..     117     161 .. 0.80
   2 ?   -0.7   0.0       0.5   1.5e+03      20      37 ..     334     351 ..     328     353 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00039
     DUF2933  15 hrahllgllPfllL..LlCPlmHlFMhgghgghggh 48 
                 h+ h+l ++P  +L  ++ P   lF hggh++h+++
  EFC35417.1 122 HAFHNLFIIPLFVLvvFIIPESPLFIHGGHHDHEEE 157
                 888888888876654588999************986 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.5
     DUF2933  20 lgllPfllLLlCPlmHlF 37 
                 lg+ ++ l+ + P m l+
  EFC35417.1 334 LGVSVWQLFCIFPTMFLV 351
                 79999**********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (540 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1561  (0.0870656); expected 358.6 (0.02)
Passed bias filter:                      631  (0.0351944); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.78u 0.35s 00:00:01.12 Elapsed: 00:00:00.52
# Mc/sec: 3120.89
//
Query:       EFC35418.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.7    7.4   9.0       0.28   10.6   3.0    1.9  2  PIEZO     Piezo


Domain annotation for each model (and alignments):
>> PIEZO  Piezo
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   3.0   1.5e-05      0.28     104     200 ..      19     135 ..       9     155 .. 0.62
   2 ?   -0.2   0.4     0.032   5.7e+02     110     129 ..     174     193 ..     151     206 .. 0.55

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 1.5e-05
       PIEZO 104 rkeeekksleqlkrqmerikakqqkikkg..............kkeseeeelakeeeee.............eeeaeeekkkse............... 160
                 r+  +   l++l +++e+ik +++  + +              +              +             +          +               
  EFC35418.1  19 RESDDLDDLDDLINRTENIKLNYETESGTddetdsssdgkgefT--------------SvslntpsdnrksnS----------Srriiesdsdnsdeei 93 
                 45556677899999*********974444444443333322220..............122222221222220..........1233444444444445 PP

       PIEZO 161 ..kkkwwrPwvdhasvvrsgdYylFesdseeeeeeeekeeee 200
                   +++ ++P  +++s v+sg  +l ++ s+ + ++e+ +eee
  EFC35418.1  94 slNTTTVKPNSSNNSTVNSGKIILKDHHSDSDSDSEQDDEEE 135
                 55899999****************997776666655544443 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.032
       PIEZO 110 ksleqlkrqmerikakqqki 129
                 + +++   +++r+k++q  +
  EFC35418.1 174 TRISKTSDKTKRVKKNQSTF 193
                 22222233333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1628  (0.0908026); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1264.72
//
Query:       EFC35419.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.5e-05   23.0   3.2    8.9e-05   22.6   2.4    1.7  2  PARP_reg    Poly(ADP-ribose) polymerase, regulatory domain
    0.00022   21.2   1.1     0.0025   17.8   0.3    2.8  2  WGR         WGR domain
  ------ inclusion threshold ------
       0.11   13.1   1.6       0.94   10.1   0.0    2.6  2  Phage_pRha  Phage regulatory protein Rha (Phage_pRha)
       0.12   12.3   0.6         18    5.3   0.1    2.4  2  Trm56       tRNA ribose 2'-O-methyltransferase, aTrm56
        3.8    7.7   7.7         11    6.1   0.0    2.5  3  Fib_alpha   Fibrinogen alpha/beta chain family


Domain annotation for each model (and alignments):
>> PARP_reg  Poly(ADP-ribose) polymerase, regulatory domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       3.1   1.1e+04       5      27 ..       5      27 ..       3      34 .. 0.63
   2 !   22.6   2.4   2.5e-08   8.9e-05      34     126 ..     138     234 ..     110     242 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3.1
    PARP_reg  5 kevqeLiklifdvelmkkamkel 27
                k+v+++ ++i  ++++++++k++
  EFC35419.1  5 KRVNNFSSTIHPIRSFSSSVKNF 27
                55666666666666666666655 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 2.5e-08
    PARP_reg  34 mPLGkLskeqikkgyevLkelselikkkekaeklkeklldlsneFytlIPhdfgrkrppvidteeelkkklelles....Lsdievaskllkaekee 126
                 +  G+ +keq+ ++ ++L+el+++ ++ +++e++ +++ +   + y +IP+++ + +  +i+++++ ++ ++ll++    L+ + +  k+ k+++++
  EFC35419.1 138 VGVGSVTKEQLDSAQSILDELYKVNENFKNDEDFLNSFNEKLLKLYAVIPRKMKKVQDYLINDKSNKESAASLLDDqqeiLDVMATQVKITKHDQSD 234
                 5689***********************99998899999999999*******9988889****************99445444444444555544433 PP

>> WGR  WGR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.3     7e-07    0.0025      11      75 ..      42      93 ..      33      97 .. 0.76
   2 ?   -2.1   0.0       1.1   4.1e+03      59      74 ..     169     184 ..     161     189 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 7e-07
                TTTEEEEEEEEE.EE-TTS-EEEEEE-S-TTS----EEEEESSHHHHHHHHHHHHHHHHSS-STT CS
         WGR 11 arnsnkFYkiqlleddlfggyslfvrWGRiGtrGqtklksfdseeeAikefeklfaeKtkkgyee 75
                ++n+nk+Y+++       ++ ++++ +GR+G +G           + ++e + l+++K kkgy +
  EFC35419.1 42 SKNNNKYYEMTE------KDGEIHIVYGRVGATGIAIK-------ASLSEWDSLVRSKMKKGYVD 93
                68**********......88899999*****9985433.......44567777777777777765 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.1
                 HHHHHHHHHHHSS-ST CS
         WGR  59 kefeklfaeKtkkgye 74 
                 ++f + f+eK  k y+
  EFC35419.1 169 EDFLNSFNEKLLKLYA 184
                 4577778888877775 PP

>> Phage_pRha  Phage regulatory protein Rha (Phage_pRha)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   0.00026      0.94      23      79 ..      19      76 ..       2      82 .. 0.62
   2 ?    1.3   0.5      0.14     5e+02      38      65 ..     172     221 ..     112     230 .. 0.52

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00026
  Phage_pRha 23 kliedleefgkelnfe.......eseykdsngretkvylltrdgftll.vmgftgkkavefkaay 79
                +  +++++f ++   +        +++k    ++ k+y++t+++ ++  v+g  g+ ++++ka +
  EFC35419.1 19 SFSSSVKNFTNT---AgryckliMVSSK----NNNKYYEMTEKDGEIHiVYGRVGATGIAIKASL 76
                333333333333...1444323233333....3569****877666654*************975 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.14
  Phage_pRha  38 e.....................eseykdsngretkvylltrdgftll.vm 65 
                                       ++  ++ +++++  + l  d+ ++l vm
  EFC35419.1 172 LnsfnekllklyaviprkmkkvQDYLINDKSNKESAASLLDDQQEILdVM 221
                 12333334444444444444543333444444555555555555555455 PP

>> Trm56  tRNA ribose 2'-O-methyltransferase, aTrm56
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1    0.0055        20      11      56 ..      18      63 ..      10      75 .. 0.87
   2 ?    5.3   0.1    0.0051        18      12      97 ..      78     163 ..      68     174 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0055
                --HHHHHHC-S...SEEEEE-TTSEEHHHHHHHHHC-SE.EEEEE- CS
       Trm56 11 kslkklikefkkeggivvhltmyGenieevieeikkkekdllvvvG 56
                +s ++ +k+f ++ g  ++l m   + ++   e+++k+ ++ +v G
  EFC35419.1 18 RSFSSSVKNFTNTAGRYCKLIMVSSKNNNKYYEMTEKDGEIHIVYG 63
                677899****************************999999999966 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0051
                 -HHHHHHC-S...SEEEEE-TTSEEHHHHHHHH..HC-SE.EEEEE------TCHHHHSSEEEESSSS---HHHHHHHHHHHHC.--T CS
       Trm56  12 slkklikefkkeggivvhltmyGenieevieei..kkkekdllvvvGaekvprevyeladynvsvgnqPhsevaalaifldrllegke 97 
                 ++ +l+++    +   v +t  G +++++ ++i  ++++ d+  ++      +++  +++ynv+vg+  +  + +   +ld+l++ +e
  EFC35419.1  78 EWDSLVRSKM--KKGYVDMTNLGSDMTNAGDDIylENSSPDVKSLISELNNFSNISIVSNYNVGVGSVTKEQLDSAQSILDELYKVNE 163
                 5666666644..34467888888888888888833334447777777777777888899*******9999999998889999988765 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0    0.0032        11      26      73 ..       3      50 ..       1     103 [. 0.71
   2 ?   -2.3   0.0       1.3   4.7e+03      30      49 ..     114     129 ..     107     153 .. 0.52
   3 ?    3.0   3.8      0.03   1.1e+02      22     102 ..     154     232 ..     150     252 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0032
                CCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha 26 llkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqkskk 73
                + k  ++++ +++ +++  ++++n t++a ++ k i+ s ++++k ++
  EFC35419.1  3 MMKRVNNFSSTIHPIRSFSSSVKNFTNTAGRYCKLIMVSSKNNNKYYE 50
                445555666666666666666666666666666666666666665544 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.3
                 CCCCCHHHCCCCCCCCCCCC CS
   Fib_alpha  30 ekdvkkdlekleneleeisn 49 
                       d+++l +el+++sn
  EFC35419.1 114 S----PDVKSLISELNNFSN 129
                 3....333333333333333 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.03
                 HHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHH CS
   Fib_alpha  22 lqdlllkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqes 102
                 + d l k+++++k+d + l++  e++ + +  + + +k+++d+l +++++k+   +++ + ++ l+  ++  + +i+++ +
  EFC35419.1 154 ILDELYKVNENFKNDEDFLNSFNEKLLKLYAVIPRKMKKVQDYLINDKSNKESAASLLDDQQEILD--VMATQVKITKHDQ 232
                 5578899999999999999999999999999999*************9999999999999999999..5555555555543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1390  (0.077528); expected 358.6 (0.02)
Passed bias filter:                      554  (0.0308997); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 1651.62
//
Query:       EFC35420.1  [L=117]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.6e-34  115.6   0.0    1.1e-33  115.4   0.0    1.1  1  FKBP_C    FKBP-type peptidyl-prolyl cis-trans isomerase
  ------ inclusion threshold ------
       0.15   12.2   0.0       0.77    9.9   0.0    1.9  1  FKBP_N_2  BDBT FKBP like N-terminal


Domain annotation for each model (and alignments):
>> FKBP_C  FKBP-type peptidyl-prolyl cis-trans isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.4   0.0   1.3e-37   1.1e-33       5      94 .]      26     114 ..      22     114 .. 0.96

  Alignments for each domain:
  == domain 1  score: 115.4 bits;  conditional E-value: 1.3e-37
                 B-TTCEEEEEEEEEETTSSEEEEHCCHTSEEEEETTSSSSCHHHHHHHTTSBTT-EEEEEEEGGGTTTTTTBCTTTB.TTSEEEEEEEEE CS
      FKBP_C   5 akegdtVtvhykgkledgkvfdssrsrakplefkvGsgqvikGfeealegmkvGekrtltippelaYgekglaggvippnatLvFeveLl 94 
                 +  g++V+vhy+g+l++gk+fdss++r++p++f++G gqvi+G++ ++++mk+Gek+ l+ip+e+aYg+++  ++ ip+n+tL+FeveLl
  EFC35420.1  26 PPHGSKVSVHYTGTLTNGKKFDSSVDRGTPFSFNLGLGQVIRGWDLGVKTMKKGEKAILEIPSEYAYGSQEI-PKLIPANSTLIFEVELL 114
                 6789********************************************************************.879************97 PP

>> FKBP_N_2  BDBT FKBP like N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   8.6e-05      0.77       4      88 ..       8      86 ..       6     115 .. 0.63

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 8.6e-05
    FKBP_N_2  4 adksisKevlklgfqklekPtevsscivlveklqnveerkdqllekleleeekeiviGealteideyierlleqmklgEtaevti 88
                +d  ++K ++ +g+   e P ++s+++v+      +++ k+     ++       ++G  l ++ +  +  +++mk+gE+a  +i
  EFC35420.1  8 KDGQVKKRIITQGSG-AELPPHGSKVSVHYTGT--LTNGKKF-DSSVDRGTPFSFNLG--LGQVIRGWDLGVKTMKKGEKAILEI 86
                67789********77.***********998766..5544433.222221233333333..3344455566666666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (117 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       211  (0.0117686); expected 358.6 (0.02)
Passed bias filter:                      202  (0.0112667); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.47
# Mc/sec: 753.55
//
Query:       EFC35421.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       637  (0.035529); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 2099.44
//
Query:       EFC35422.1  [L=351]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       791  (0.0441185); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2161.86
//
Query:       EFC35423.1  [L=377]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       598  (0.0333538); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2474.61
//
Query:       EFC35424.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.5e-17   61.5   0.0    1.4e-16   60.8   0.0    1.3  1  Lysine_decarbox  Possible lysine decarboxylase
      9e-13   48.1   0.0    9.3e-13   48.0   0.0    1.1  1  LDcluster4       SLOG cluster4 family
  ------ inclusion threshold ------
      0.046   13.3   0.3      0.071   12.7   0.3    1.2  1  C9orf72-like     C9orf72-like protein family


Domain annotation for each model (and alignments):
>> Lysine_decarbox  Possible lysine decarboxylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.8   0.0   2.4e-20   1.4e-16       3     131 ..      48     167 ..      46     168 .. 0.89

  Alignments for each domain:
  == domain 1  score: 60.8 bits;  conditional E-value: 2.4e-20
                      HHHHHHHHTTS-EEEEEECCHHHHHCCTTT-SEEEEESSHHHHHHHHHHHESEEEE-S-SHHHHHHHHHHHHHHHTTSS-S.EEEEEEGGGCCH CS
  Lysine_decarbox   3 avakgaleaggrviGiipkillaeeapneevnelvivedmeeRkealveladafvilPGGiGTleElleiltliqlgkhqkvPiillnpkgyyd 96 
                       v k  +e ggrvi i  ++  a++  +e ++e +  ++++eR++ l+e ++ ++ lPGGiGT+ El+++++ ++ +k ++v i l+n +g+++
       EFC35424.1  48 IVPKYFHERGGRVISI--NTKEANNGLDECYGENFLYDTLQERQRRLIENSELVICLPGGIGTISELFDVMA-MNNNKIRNVKILLYNFEGFFN 138
                      5666678999999999..777778899*********************************************.667777888************ PP

                      HHHHHHHHHHHTTSS-GGGGGCEEEESSHHHHHHH CS
  Lysine_decarbox  97 kllefletlveegtisekareliivvddpeevlek 131
                      +++e +      + ++++  e++iv++++++++e+
       EFC35424.1 139 HMIEQI------KLLGKNTDEYLIVTNEVNDLMER 167
                      ******......78899999999999999888875 PP

>> LDcluster4  SLOG cluster4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.0   0.0   1.6e-16   9.3e-13       2     121 ..       1     122 [.       1     165 [. 0.84

  Alignments for each domain:
  == domain 1  score: 48.0 bits;  conditional E-value: 1.6e-16
  LDcluster4   2 lkigVmGsaete.akeealelaeelGrliAkegavlltGgrt.GvmeaaskGakeagGltvGilpassekehsnkyvdiiiyTGlglagRnlilvlssd 98 
                 +kig++G  +t+  ++  +e  + l+ li +e++ ++ Gg + Gvm+ + k  +e+gG ++ i  ++ ++   + y +  +y  l+ + R   l+  s+
  EFC35424.1   1 MKIGIFGGCNTTrLTPVLEEELKVLASLINTEQHLVVYGGGKkGVMSIVPKYFHERGGRVISINTKEANNGLDECYGENFLYDTLQ-E-RQRRLIENSE 97 
                 58*****8887779997888************99999998877***********************99999999999999999888.4.888999**** PP

  LDcluster4  99 vviaiggrsGTlsEi..alaleegk 121
                  vi+++g++GT+sE+  ++a++++k
  EFC35424.1  98 LVICLPGGIGTISELfdVMAMNNNK 122
                 **************84446666665 PP

>> C9orf72-like  C9orf72-like protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.3   1.2e-05     0.071      56     113 ..     117     171 ..     112     174 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.2e-05
  C9orf72-like  56 ilpekelakylplielcedrlkdiikklrallkkekpeekltrvtdeiqrilellssl 113
                    ++++++++++ l  ++e +++++i +++ l k+ +++ +    t+e+  ++e l++l
    EFC35424.1 117 AMNNNKIRNVKILLYNFEGFFNHMIEQIKLLGKNTDEYLIV---TNEVNDLMERLKEL 171
                   49********************************9999999...**********9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       588  (0.032796); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 1039.22
//
Query:       EFC35425.1  [L=603]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-49  165.1  30.4    3.2e-09   36.4   0.0   10.8 11  DUF4116          Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.015   15.5   0.7      0.044   14.0   0.0    2.1  3  Helitron_like_N  Helitron helicase-like domain at N-terminus
       0.63    9.7   3.3        1.8    8.3   2.2    2.2  2  FRG1             FRG1-like domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.0   2.3e-10   1.4e-06       1      49 []      84     137 ..      84     137 .. 0.88
   2 !   11.7   0.0   2.7e-05      0.16      21      49 .]     134     162 ..     129     162 .. 0.90
   3 !   16.8   0.0     7e-07    0.0042       1      30 [.     139     168 ..     139     170 .. 0.96
   4 !   25.6   0.1   1.3e-09   7.5e-06       1      45 [.     164     208 ..     164     209 .. 0.93
   5 !   30.0   0.0   5.1e-11   3.1e-07       2      49 .]     214     260 ..     214     260 .. 0.97
   6 !   36.4   0.0   5.4e-13   3.2e-09       1      48 [.     237     284 ..     237     286 .. 0.94
   7 !   11.0   0.0   4.4e-05      0.26       1      36 [.     262     297 ..     262     313 .. 0.91
   8 !    8.0   0.1   0.00038       2.3       2      46 ..     319     365 ..     318     370 .. 0.88
   9 !   12.3   2.6   1.8e-05      0.11       3      39 ..     398     461 ..     396     474 .. 0.74
  10 !   17.3   4.7   4.8e-07    0.0028       1      48 [.     448     517 ..     448     518 .. 0.88
  11 !   27.8   0.0   2.6e-10   1.5e-06       1      46 [.     553     598 ..     544     599 .. 0.95

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 2.3e-10
     DUF4116   1 DrEivleavkkng.salkyl.seeLknDkeivlkAvkqngtal..syas.eeLr 49 
                 Dr +++ av+++g +alk++ +e++k+D+ei+++ ++++g++l  + ++ eeLr
  EFC35425.1  84 DRLLIWLAVRSFGvNALKHIrNEKFKCDREIIKAGLESDGSILfaCTIPrEELR 137
                 999*********989*****99******************98844666666665 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 2.7e-05
     DUF4116  21 eeLknDkeivlkAvkqngtalsyaseeLr 49 
                 eeL+ D e++lk ++ ++ +l+ a + +r
  EFC35425.1 134 EELRDDEELILKGLETCPRVLELANDRIR 162
                 89*******************99887765 PP

  == domain 3  score: 16.8 bits;  conditional E-value: 7e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeiv 30 
                 D+E++l+ +++++ +l+ ++++++nD+ +v
  EFC35425.1 139 DEELILKGLETCPRVLELANDRIRNDRSVV 168
                 9**************************998 PP

  == domain 4  score: 25.6 bits;  conditional E-value: 1.3e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 Dr +v  ++k++g+ lky+ e+ knD++ +  A+kqn  + ++++
  EFC35425.1 164 DRSVVESVLKRDGMQLKYCGESVKNDRNMIGIALKQNIESCKFIP 208
                 999**********************************87777766 PP

  == domain 5  score: 30.0 bits;  conditional E-value: 5.1e-11
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +++vl +v +ng+ l +++ e+ +++++v+  vkqng al++as+eLr
  EFC35425.1 214 EQLVLRVVLSNGLLLVHFP-EFNSNRNVVIVSVKQNGLALEFASNELR 260
                 579****************.***************************8 PP

  == domain 6  score: 36.4 bits;  conditional E-value: 5.4e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 +r +v   vk+ng+al+++s+eL++D eiv+ A++  ++al  as+ L
  EFC35425.1 237 NRNVVIVSVKQNGLALEFASNELRSDEEIVKLAMETQKDALLLASPTL 284
                 68888889*************************************987 PP

  == domain 7  score: 11.0 bits;  conditional E-value: 4.4e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 D+Eiv+ a+++   al  +s+ L   ke++   v +
  EFC35425.1 262 DEEIVKLAMETQKDALLLASPTLLIRKEFMDNLVSK 297
                 9*****************************999875 PP

  == domain 8  score: 8.0 bits;  conditional E-value: 0.00038
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkA..vkqngtalsyase 46 
                 +E++l   ++  +  +yls++L+ D +i + A  ++   ++++y+s+
  EFC35425.1 319 EEFMLSRYERGYEFPNYLSNSLSVDNWIRILAgnINLFRSFFEYYSK 365
                 8***************************9999677777789999996 PP

  == domain 9  score: 12.3 bits;  conditional E-value: 1.8e-05
     DUF4116   3 EivleavkkngsalkylseeLkn...........................DkeivlkAvkqngt 39 
                 E+ +e + k +s l+y++++Lk+                           ++e++l+ +k++++
  EFC35425.1 398 ELQKEMILKQPSLLYYFDPSLKSdvplmsrilretslyieinyfdkslfeNREFLLALLKKYSY 461
                 8889999999*************66666666666666666666666666677777777777665 PP

  == domain 10  score: 17.3 bits;  conditional E-value: 4.8e-07
     DUF4116   1 DrEivleavkkngs....................alkyls...eeLknDkeivlkAvkqngtalsyaseeL 48 
                 +rE+ l ++kk+++                    ++++     e+++n+ke +++A+k+n++ ++ +s++L
  EFC35425.1 448 NREFLLALLKKYSYnwvfittfddelyecgvvdsSYYF-GkylEKYCNNKEYLIRAIKRNSNLFEILSHKL 517
                 89**********99999999999999999999965544.4255788*******************999987 PP

  == domain 11  score: 27.8 bits;  conditional E-value: 2.6e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 D+E++   +k+ ++++ +++++LknD+++v++ v ++g +l+ +s+
  EFC35425.1 553 DKELIIGHLKISPMSFPFIDPSLKNDIDVVMATVTKHGGVLKLLSP 598
                 89999999******************************99999886 PP

>> Helitron_like_N  Helitron helicase-like domain at N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       1.1   6.6e+03      13      40 ..      46      71 ..      28     107 .. 0.53
   2 ?   -2.5   0.0      0.85   5.1e+03      16      50 ..     332     369 ..     318     405 .. 0.60
   3 ?   14.0   0.0   7.3e-06     0.044      36     108 ..     519     590 ..     498     592 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.1
  Helitron_like_N 13 hsrflflafnllqqyvvdayakveeerl 40
                     hsr ++l  + +q y   ++++v+ ++ 
       EFC35425.1 46 HSRSQHLTNENVQ-Y-LRMAVRVKRRSA 71
                     3333333333333.1.233333333333 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.85
  Helitron_like_N  16 flflafnllqqyvvdayakveeerlsflrk......nqkel 50 
                      f  +  n l    vd ++++ + +++ +r       + kel
       EFC35425.1 332 FPNYLSNSLS---VDNWIRILAGNINLFRSffeyysKSKEL 369
                      3334444444...8889998888888887765555544444 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 7.3e-06
  Helitron_like_N  36 eeerlsflrknqkelraesltgeeLkealeeetedeelkllgklvilpssvpgsprymqekrqdlmaivrelg 108
                      ee+r++  ++n ke+++ ++  +++++  +ee++d+ +  +g+l i p s+p  +++ ++    +ma+v+++g
       EFC35425.1 519 EEDRMQLTKNNSKEVKTTNYLTDRIERLSDEEKKDK-ELIIGHLKISPMSFPFIDPSLKNDIDVVMATVTKHG 590
                      789*****************999********96666.59******************************9998 PP

>> FRG1  FRG1-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.23   1.4e+03      34      60 ..     378     406 ..     371     409 .. 0.75
   2 ?    8.3   2.2    0.0003       1.8     124     165 ..     512     553 ..     488     555 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.23
        FRG1  34 kvasdeki..slKsgyGkYlgvdkegils 60 
                 k+a++ ki   +K +y  Yl+ +ke il 
  EFC35425.1 378 KLAQKMKIdaDFKESYSDYLELQKEMILK 406
                 666666653259***********999985 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0003
        FRG1 124 ktkdrirvedreklrekeskyvkkfqkiqdkklrldkedvkr 165
                   + +  +edr +l++ +sk+vk  + + d+  rl++e++k+
  EFC35425.1 512 ILSHKLDEEDRMQLTKNNSKEVKTTNYLTDRIERLSDEEKKD 553
                 45677899***********************99******986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (603 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1027  (0.0572815); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.36s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 3358.68
//
Query:       EFC35426.1  [L=132]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.066   13.6   0.0       0.15   12.5   0.0    1.6  1  GCK       GCK domain


Domain annotation for each model (and alignments):
>> GCK  GCK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   8.6e-06      0.15       7      31 ..      53      81 ..      49      87 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8.6e-06
         GCK  7 eFmkgGgCkesfiawekcv....eeaekn 31
                 F+k+ +Ck++f+ +ek +    ++ae++
  EFC35426.1 53 VFIKDPDCKDAFMGLEKLIfrvvHNAESK 81
                59**************9774444555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       439  (0.0244855); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 768.95
//
Query:       EFC35427.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.2e-20   71.5   0.0      1e-19   71.2   0.0    1.0  1  Polyketide_cyc2  Polyketide cyclase / dehydrase and lipid tra
      0.001   19.3   0.1     0.0013   19.0   0.1    1.4  1  Polyketide_cyc   Polyketide cyclase / dehydrase and lipid tra


Domain annotation for each model (and alignments):
>> Polyketide_cyc2  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.2   0.0   1.1e-23     1e-19       1     141 [.       3     151 ..       3     152 .. 0.85

  Alignments for each domain:
  == domain 1  score: 71.2 bits;  conditional E-value: 1.1e-23
                      EEEEEEEEEESS-HHHHHHHHTTTTGGGGT-TTEEEEECSESTSSSTTTEEEEECCCS........SEEEEEEEEEETTTTEEEEEEE..SSS- CS
  Polyketide_cyc2   1 mvkvtvsvviaappekVwalvsdfenwprWhpevarveleggggpargvegtvrvggr........gtvreelvevdpegrllsyriv.kpvpv 85 
                      +vkv +s+vi+a++e+Vw +v +f+++p+W   v+++ legg ++   + g+vrv+++        +++re+l+++d ++++++y+i  +p+p+
       EFC35427.1   3 QVKVYRSAVINASVETVWQVVKNFNELPKWTGVVSDSVLEGGMQD--NSIGCVRVVSLlnpnpqddRPIREQLIAYDSRNHSFTYKILsGPKPF 94 
                      5899*********************************99986666..667****99999999999888*********99********7767776 PP

                      T...SEEEEEEEEECCET..EEEEEEEEEEEE--TT--HHHHHHHHHHHHHHHHHHHHHHH CS
  Polyketide_cyc2  86 a...nyvatwtvtpdggg..trvtwtgefdagplggpfekpaaakavkgdleagLerLkar 141
                      +    y at+t+    +   t ++w+ ef +      ++ + ++k+ ++ + +g++ L+++
       EFC35427.1  95 EyfnEYYATVTLVKITDSnqTFIEWKSEFTC----PQGNQEQFEKFAGAVYMKGIKSLQQQ 151
                      5333777888888866655588********8....55566778999999999999999875 PP

>> Polyketide_cyc  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.1   1.4e-07    0.0013       1      35 [.      12      45 ..      12     134 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 1.4e-07
                    ESS-HHHHHHHHTTTGGCCSCCCCEEEEEE.SSSE CS
  Polyketide_cyc  1 vpapadqvyalvadvesypeflphcssvevleeae 35
                    ++a++++v+++v +++ +p+++  +s+++ le   
      EFC35427.1 12 INASVETVWQVVKNFNELPKWTGVVSDSV-LEGGM 45
                    79********************9888654.33333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       521  (0.0290591); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.35s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 919.48
//
Query:       EFC35428.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0035   17.6   0.1       0.39   11.0   0.0    2.7  3  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
  ------ inclusion threshold ------
       0.59   10.3   2.1        1.1    9.4   0.1    2.6  3  NHL          NHL repeat


Domain annotation for each model (and alignments):
>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.3   1.1e+04      36      68 ..      28      60 ..      23      66 .. 0.70
   2 !    3.6   0.0    0.0092        82      49      74 ..     191     217 ..     186     222 .. 0.87
   3 !   11.0   0.0   4.3e-05      0.39       1      90 [.     233     321 ..     233     323 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.3
  ANAPC4_WD40 36 kedsevrsLaWkpdgklLavaysdgevrlldae 68
                 +++  + +L+ k +++ L  a   g +++l ++
   EFC35428.1 28 HKQLDIFNLKIKLNETNLKKARGGGGISILLSY 60
                 456677778888888888777777777776555 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.0092
  ANAPC4_WD40  49 dgklLavaysdg.evrlldaesgkvvh 74 
                   g+l++va  d+ +++l+d+ +g++++
   EFC35428.1 191 RGNLIVVADTDNkRLKLYDSLDGNLLK 217
                  699*****9999789******999886 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 4.3e-05
  ANAPC4_WD40   1 lswcptmDLiAlatedgellvfRlngqrvwtleedkedsevrsLaWkpdg.klLavaysdgevrlldaesgkvvhslsvksekavtclgWg 90 
                  + ++ + DL+ ++t +++   + l+ +  +++++ ++ +++ +L+++p+  k+L   ++ + + +++ es kv ++++ + +  v+++++ 
   EFC35428.1 233 MIYSKELDLFLIVTREKSFFKCKLSHNLQFETSQLSTTQSIWCLCYEPSSrKVLFPNTNSSLICVMNLESMKVEKEYKGEGT--VSSISFD 321
                  689********************************************98725777777788899999999999988876655..7777765 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1      0.51   4.5e+03       7      16 ..      79      88 ..      78      88 .. 0.82
   2 ?   -3.7   0.0       1.7   1.6e+04      21      27 ..     153     159 ..     153     159 .. 0.82
   3 ?    9.4   0.1   0.00012       1.1      11      26 ..     191     206 ..     188     208 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.51
                EEEETTTEEE CS
         NHL  7 vavdsnGdiy 16
                v ++++G+i+
  EFC35428.1 79 VYLNDDGNII 88
                67889**996 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.7
                 CCTEEEE CS
         NHL  21 enhrvqv 27 
                 e+++++v
  EFC35428.1 153 ETNCIWV 159
                 6799998 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00012
                 TTTEEEEEECCCTEEE CS
         NHL  11 snGdiyVaDsenhrvq 26 
                  ++ i+VaD+ n r++
  EFC35428.1 191 RGNLIVVADTDNKRLK 206
                 6899*********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.41
# Mc/sec: 2500.94
//
Query:       EFC35429.1  [L=475]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-43  144.4  17.6    1.4e-15   56.7   0.0    7.1  8  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.1   0.00052       9.4      30      48 ..     167     185 ..     149     189 .. 0.67
   2 !   14.2   0.3   1.5e-06     0.027       4      46 ..     191     233 ..     165     234 .. 0.73
   3 !   23.6   0.5   1.7e-09   3.1e-05       2      44 ..     241     284 ..     240     289 .. 0.88
   4 !   12.7   0.6   4.6e-06     0.082      14      47 ..     279     312 ..     271     315 .. 0.87
   5 !   30.6   0.7   1.1e-11     2e-07       1      48 [.     290     339 ..     290     340 .. 0.86
   6 ?   -2.3   0.1      0.22   3.9e+03      23      41 ..     366     384 ..     360     387 .. 0.66
   7 !   56.7   0.0   7.7e-20   1.4e-15       1      49 []     392     440 ..     392     440 .. 0.99
   8 !   19.6   0.0     3e-08   0.00054       2      27 ..     443     468 ..     442     471 .. 0.94

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.00052
     DUF4116  30 vlkAvkqngtalsyaseeL 48 
                  + A++ +++++ y+++ +
  EFC35429.1 167 TMHAIELDPKCYAYVPDYI 185
                 4667777777777777665 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 1.5e-06
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 i+++++ +n+s  + +++eL  D ++v+   k++ ++l yas+
  EFC35429.1 191 IAKKVFIRNPSLGTLIPKELLEDTDFVMDVYKSSQSILFYASP 233
                 4444444555544557777777999999999999999999997 PP

  == domain 3  score: 23.6 bits;  conditional E-value: 1.7e-09
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqng.talsya 44 
                 r ++ ea+k++ + ++++see++ D+ei+  ++ ++  +++ y+
  EFC35429.1 241 RVFMIEALKSDVCLIRNCSEEIRTDREIIDMIIDIDAaSSFQYI 284
                 559**************************999988887777777 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 4.6e-06
     DUF4116  14 salkylseeLknDkeivlkA.vkqngtalsyasee 47 
                 s+++y+  ++k D +iv+kA  k+n t+l y+  +
  EFC35429.1 279 SSFQYIG-KFKEDEDIVKKAlFKSNFTILHYINSD 312
                 6899999.9**********98899999**999766 PP

  == domain 5  score: 30.6 bits;  conditional E-value: 1.1e-11
     DUF4116   1 DrEivleavkkngs.alkyl.seeLknDkeivlkAvkqngtalsyaseeL 48 
                 D++iv++a+ k ++ +l+y+ s+ L n++e+vl ++k+ng+ ++ ++e +
  EFC35429.1 290 DEDIVKKALFKSNFtILHYInSDFLLNNRELVLTILKSNGKYINEMPEAI 339
                 9*******6665555*****66779******************9999865 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 0.22
     DUF4116  23 LknDkeivlkAvkqngtal 41 
                 + +D+e  + +++ n++ l
  EFC35429.1 366 IESDREDFKSILQFNPDLL 384
                 5677777777777776655 PP

  == domain 7  score: 56.7 bits;  conditional E-value: 7.7e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+ +ea++++g++l+++see+k Dke+vl Av +ng+al yas++L+
  EFC35429.1 392 DRELLKEALSHCGFCLRFASEEFKADKELVLTAVTKNGSALMYASPKLK 440
                 9*********************************************997 PP

  == domain 8  score: 19.6 bits;  conditional E-value: 3e-08
     DUF4116   2 rEivleavkkngsalkylseeLknDk 27 
                 +Eivl av+++g+a++++s++++n k
  EFC35429.1 443 EEIVLAAVTNDGKAIRFASKRFSNQK 468
                 8**********************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       598  (0.0333538); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 2990.98
//
Query:       EFC35430.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      2e-22   79.8   0.2      4e-22   78.8   0.2    1.6  1  Pkinase      Protein kinase domain
    8.5e-22   77.7   0.0    7.1e-18   64.8   0.0    2.1  2  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.8   0.2   4.5e-26     4e-22     122     215 ..       3      99 ..       1     205 [. 0.69

  Alignments for each domain:
  == domain 1  score: 78.8 bits;  conditional E-value: 4.5e-26
                 SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-.STTTSSHHHHHHHHHHTHHH CS
     Pkinase 122 rDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkp.pfsgekgkekvekeldqlek 215
                 rDlKp NiL++++   K++DFGl+k  + +sk  +t +vg+  Y+APEvl +++y +k+Dv+s ++i+++l++ ++ +f+ + g++++++ ++ +++
  EFC35430.1   3 RDLKPGNILLSNDLTPKVCDFGLSKLSNDNSKttKTGQVGSLLYMAPEVLLGKNYNEKSDVYSFAIIMWQLIFDENcIFQYNYGTNQKYSTIMPTQE 99 
                 9**************************99999878889*********************************99875267766677766666655222 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.8   0.0   7.9e-22   7.1e-18     127     200 ..       3      75 ..       1     142 [. 0.88
   2 !   11.3   0.0   1.7e-05      0.15     209     259 .]     152     202 ..     146     202 .. 0.88

  Alignments for each domain:
  == domain 1  score: 64.8 bits;  conditional E-value: 7.9e-22
                  ST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHT CS
  Pkinase_Tyr 127 rdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEift 200
                  rdl   N+Lls++ + k++DfGL++   +d++ ++k+++  ++ +mapE+l  k++++ksDv+sf++++w ++ 
   EFC35430.1   3 RDLKPGNILLSNDLTPKVCDFGLSKLS-NDNSKTTKTGQVGSLLYMAPEVLLGKNYNEKSDVYSFAIIMWQLIF 75 
                  9************************88.888888999999******************************9875 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 1.7e-05
                  SHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 209 lkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                  l++++ l+ ++++   ek  ++ ++l ++++ +w ed  +Rp+fs+l e+l
   EFC35430.1 152 LNQAKRLSIIRQEDPFEKHLTVLDALFSMVQCSWCEDFYQRPSFSKLAEQL 202
                  56667778889999999999999************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       517  (0.028836); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1384.84
//
Query:       EFC35431.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.084   13.8   0.1       0.16   12.9   0.1    1.4  1  Cytochrom_C_2  Cytochrome C'
       0.24   11.9  12.9       0.46   11.0  12.9    1.5  1  APG6_N         Apg6 coiled-coil region
        0.5   10.4   2.9       0.73    9.9   2.1    1.7  1  DUF1664        Protein of unknown function (DUF1664)


Domain annotation for each model (and alignments):
>> Cytochrom_C_2  Cytochrome C'
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   2.6e-05      0.16      13      98 ..       1      87 [.       1      96 [. 0.84

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.6e-05
                   HHHHHHHHHHHHTTSST--HHHHHHHHHHHHHHHCSGGGGC-TTGSS..SSS--B-THHHHTHHHHHHHHHHHHHHHHHHHHHHHCTS CS
  Cytochrom_C_2 13 igknmgklgamlkgeapydaeavaaaaealaalakklpalFpegsdk..gektkakpeiWedkekfkakaaaleeaaaeLaaaakagd 98
                   +++n +++++m++g+ + + ++++++ ++  ++ +++ +lF e  d   ++++ a++++ +++e+ ++++ +l  +++eL++ +++ d
     EFC35431.1  1 MSNNSSRVNKMVSGASNCE-NTISQNNRKTLQTKASTSDLFVETVDRekRRNSIAEEKLLSENETLRQEKVDLLGRIRELEEKQNKSD 87
                   78999***********885.566666666666667779***99999888779*****************************8777766 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0  12.9   7.6e-05      0.46       6     106 ..      18     112 ..      15     128 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 7.6e-05
      APG6_N   6 CtdlLleeldkqleqaekerdaYeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwre 104
                 C +++ ++  k l++  +  d + e  ++ k++++        +e+l  e e+l++e+ +ll  ++ele+++ + ++ +++le el+   + e  ++++
  EFC35431.1  18 CENTISQNNRKTLQTKASTSDLFVETVDREKRRNSI------AEEKLLSENETLRQEKVDLLGRIRELEEKQNKSDELIRKLELELASFRNRESMEVTD 110
                 777777777777777777777666666666655444......5689******************************************99999887766 PP

      APG6_N 105 yn 106
                  +
  EFC35431.1 111 SK 112
                 54 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   2.1   0.00012      0.73      49     110 ..      57     120 ..      34     130 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00012
     DUF1664  49 qleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevre..dlseigedvesvkeav 110
                 +l +  e+l++ k +L  ri ++++k++++ e++++++ e+++ r+   ++ ++++ e + + +
  EFC35431.1  57 KLLSENETLRQEKVDLLGRIRELEEKQNKSDELIRKLELELASFRNreSMEVTDSKTELILNEI 120
                 56666799*******************************9998875114444555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1648  (0.0919181); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1588.63
//
Query:       EFC35432.1  [L=518]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-08   34.8   0.1    3.6e-08   33.9   0.1    1.4  1  VWA       von Willebrand factor type A domain
    4.8e-07   30.4   0.0      1e-06   29.3   0.0    1.6  1  VWA_2     von Willebrand factor type A domain
     0.0048   16.9   0.1       0.01   15.8   0.1    1.5  1  VWA_3     von Willebrand factor type A domain
  ------ inclusion threshold ------
       0.12   10.8   0.0       0.21   10.1   0.0    1.3  1  PaRep2b   PaRep2b protein


Domain annotation for each model (and alignments):
>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   0.1   7.9e-12   3.6e-08       3     174 ..     333     509 ..     332     510 .. 0.83

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 7.9e-12
                 EEEEE-STTSCHHHHH.....HHHHHHHHHHHHHTB.....TTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHH CS
         VWA   3 vfvlDgSgsmgeenfe.....kvkefikklveklev.....gpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyalek 91 
                 +fv D Sgsmg+++       +  + +  l+e+ e      +  ++ v+ +++ ++++  f  n  s  ++l s  ++  ++gggt+    a++ + + 
  EFC35432.1 333 IFVNDKSGSMGGSDARptsskYSNDRLGALFESCEKflevrDGSSDLVSCIMYDHSAYNCFTTNPLS--TSLVSTMSS-YVAGGGTS-FTNAMQSVSS- 426
                 6999******9988888655544455555555555255656677777******************88..899999999.68888888.8889998877. PP

                 HHHHHGTSSTTSEEEEEEEESS--CS.SHTHHHHHHHHGCTEEEEEEEESSSHHHHHHHHHSSSSCHHCEEEESSHHHHHHHHH CS
         VWA  92 lfkssagaRenakkviilltdGksnd.gdpkeaaneakeqgikvfavGvgnadekelLnkiasepgeghvftvtdfeeleelfe 174
                 l++s+  + + +k v+++++dG+++  + ++ + + + + +i ++++  g   +++ L+++a +++ g + +++d+++l  +++
  EFC35432.1 427 LISSTYPNHQSYKIVVLFMSDGEDSAdEAVSITGQLVSSHDIILHTIQLGGSSDNTGLRQMAATGR-GQFKRANDSASLAGIYQ 509
                 88888888889999**********7735999999999999*********88888888*********.**********9998886 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.0   2.3e-10     1e-06       2     107 .]     333     449 ..     332     449 .. 0.84

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 2.3e-10
       VWA_2   2 vfvlDtSgSmrngdygptrleaakdaveallksl.........pgdrvglvtfsdgpevlipltkdkakilnalrnleakgggtnlaaaLqlarkalkk 91 
                 +fv D SgSm+++d +pt   +  d + al++s            d v+ + ++++++  ++ +   +++ + + +  a gggt++++a+q +++++++
  EFC35432.1 333 IFVNDKSGSMGGSDARPTSSKYSNDRLGALFESCekflevrdgSSDLVSCIMYDHSAYNCFTTNPLSTSLVSTMSSYVA-GGGTSFTNAMQSVSSLISS 430
                 8999***********9998888888887777766666777675577*****************99999**********9.6***************976 PP

       VWA_2  92 rr...kgekrvivlitDge 107
                 +    +++k v+++++Dge
  EFC35432.1 431 TYpnhQSYKIVVLFMSDGE 449
                 6666566777777778986 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.1   2.2e-06      0.01      80     152 ..     417     494 ..     398     496 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.2e-06
       VWA_3  80 legaLkealrqp.....akpgevrsvilltDgss.aqge.ervsdlisrarekirfhalglgsslsaamlqaLAeasgGt 152
                    a++ +++       +++ +   v+ ++Dg + a  + + + +l+s +  +i +h+++lg s + + l+++A  ++G+
  EFC35432.1 417 FTNAMQSVSSLIsstypNHQSYKIVVLFMSDGEDsADEAvSITGQLVSSH--DIILHTIQLGGSSDNTGLRQMAATGRGQ 494
                 55555555532222233566666678889999974333346667888888..***************************7 PP

>> PaRep2b  PaRep2b protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   4.6e-05      0.21      10      85 ..      42     117 ..      33     128 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 4.6e-05
     PaRep2b  10 llfelrdalaeFadafkvvtreavkrkfgidlaydvrnesffkkleeivtmvedyvyrnv.averglldtsgklPkv 85 
                  + +    l+eF +++ ++t++ vk++f++++   +  + + k +e + t +e++v++++ +++ +  d s++  ++
  EFC35432.1  42 QFIQIDGLLKEFFTTHADLTNQLVKTHFRLGRII-LTTNCLDKIFEGVLTEIESHVQKELiQMRDNFNDSSREFNYI 117
                 5566677899*********************976.5566788889*************8615555556666665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (518 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       705  (0.0393218); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 3289.27
//
Query:       EFC35433.1  [L=303]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0023   16.6   0.0     0.0037   15.9   0.0    1.2  1  AMP-binding  AMP-binding enzyme


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   2.1e-07    0.0037      16      40 ..     241     267 ..     224     275 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 2.1e-07
                  E..CCSTEEEEHHHHHHHHHHHHHHHH CS
  AMP-binding  16 d..sgegqtlTYreldervnrlAagLr 40 
                  d  +++++++TY++l+erv r+++gLr
   EFC35433.1 241 DqyENKYRWFTYAQLHERVLRFGNGLR 267
                  146789********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (303 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       477  (0.0266049); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 2119.72
//
Query:       EFC35434.1  [L=644]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.5e-56  190.1   0.0    7.7e-56  189.4   0.0    1.3  1  Pkinase          Protein kinase domain
    1.5e-52  178.5   0.1    4.1e-45  154.1   0.0    2.2  2  Pkinase_Tyr      Protein tyrosine kinase
    0.00022   21.2   0.0    0.00033   20.7   0.0    1.3  1  APH              Phosphotransferase enzyme family
    0.00042   19.4   0.0     0.0022   17.0   0.0    2.0  1  Haspin_kinase    Haspin like kinase domain
  ------ inclusion threshold ------
      0.035   14.2   0.1       0.11   12.6   0.1    1.8  1  DUF2258          Uncharacterized protein conserved in archaea
      0.069   12.3   0.0       0.27   10.4   0.0    1.8  2  Fructosamin_kin  Fructosamine kinase
      0.086   12.1   0.1       0.14   11.4   0.1    1.2  1  DUF4436          Domain of unknown function (DUF4436)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  189.4   0.0     3e-59   7.7e-56       2     260 ..     334     633 ..     333     636 .. 0.87

  Alignments for each domain:
  == domain 1  score: 189.4 bits;  conditional E-value: 3e-59
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS-- CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsls 96 
                 e ++++GeG++G+V+ a   +++ +vA+K ik+e+ + ++ +++ +E ++l++l+hp ivr+y+v  ++++ y+v+ey+e+g+l++++      +++l+
  EFC35434.1 334 EIVKRIGEGAMGTVFLAN--WNETKVALKSIKTESSEISN-DEFEHEASLLNSLRHPSIVRFYGVTLSNTNKYMVVEYLENGSLDSIIAqckcGRKNLD 429
                 56899************9..9999********99887766.59*********************************************97777667788 PP

                 HHHHHHHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHH CS
     Pkinase  97 eeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl.keneyskkvDvWslGvilye 189
                  +   +i+k i++g++ylHs +   +iHrDlKp NiL+d++ + K++DFGl+k  +ss +  +t   gt  Y+APE++ +++e+++++Dv+s  +i+ye
  EFC35434.1 430 LKSKIEILKGIASGMDYLHSLKpraLIHRDLKPGNILLDSNLNPKVCDFGLSKLTSSSGSstMTMNLGTFLYMAPEIIgSGHEIGSAIDVYSFSMIMYE 528
                 88889**************988888******************************99988899***************888999*************** PP

                 HHHSS-STTTSSHHHHHHHHHHT.HHHHHHHCTSHH...HHHTTS....................................-HHHHHHHHHHT-SSGCC CS
     Pkinase 190 lltgkppfsgekgkekvekeldq.lekilkilgetkeklpeasei....................................seeakdllkkllkkdpkk 251
                 l++++ p++ +++ + ++k + + l +    l++  +++  +  +                                     ++ +dl+k++++++p++
  EFC35434.1 529 LFFEEKPYYPSNSIK-MRKVISNtLDSREGDLQQ--FSFSIPMRVvkgerpdipwnnsteletwigeyvksiesdlnyskvCSQYIDLMKQCWDQNPHN 624
                 *********444443.444444413333333333..33333333366888888888889*******************9998999************** PP

                 STTHHHHHT CS
     Pkinase 252 Rltaeellq 260
                 R+t++++ q
  EFC35434.1 625 RPTFKQITQ 633
                 ******987 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  154.1   0.0   1.6e-48   4.1e-45       2     219 ..     334     549 ..     333     561 .. 0.90
   2 !   22.4   0.1   2.4e-08   6.2e-05     227     259 .]     603     635 ..     562     635 .. 0.81

  Alignments for each domain:
  == domain 1  score: 154.1 bits;  conditional E-value: 1.6e-48
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ek 97 
                  e+ k++GeGa G+V+ ++++      e+kVa+K++k e++e +++e+ +ea+++++l+hp iv+++gv +++ + ++v+ey+++G+L++ + +    +
   EFC35434.1 334 EIVKRIGEGAMGTVFLANWN------ETKVALKSIKTESSEISNDEFEHEASLLNSLRHPSIVRFYGVTLSNTNKYMVVEYLENGSLDSIIAQCkcGR 425
                  7889****************......9****************************************************************9985568 PP

                  TTSBHHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.EEHHHHHHHH CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.ftsksDvWsf 191
                  ++l+lk+++++   +A+Gm+yL+s k   l+Hrdl   N+Ll++n   k++DfGL++ + +++  ++ + +   + +mapE++ +++ + s+ Dv+sf
   EFC35434.1 426 KNLDLKSKIEILKGIASGMDYLHSLKpraLIHRDLKPGNILLDSNLNPKVCDFGLSKLT-SSSGSSTMTMNLGTFLYMAPEIIGSGHeIGSAIDVYSF 522
                  99********************9965555****************************99.5666666777788999*******887659********* PP

                  HHHHHHHHTTSSGTTTTSHHHHHHHHHH CS
  Pkinase_Tyr 192 GvllwEiftlgespypglkneevleklk 219
                  +++++E+f   e+py   ++ ++ + ++
   EFC35434.1 523 SMIMYELFF-EEKPYYPSNSIKMRKVIS 549
                  ********9.678887766666666554 PP

  == domain 2  score: 22.4 bits;  conditional E-value: 2.4e-08
                  BTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 227 pekcpeelyelmkkcweedpeeRptfselvekl 259
                   +k++++  +lmk+cw+++p++Rptf+++++ l
   EFC35434.1 603 YSKVCSQYIDLMKQCWDQNPHNRPTFKQITQAL 635
                  4556677889*******************9876 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0   1.3e-07   0.00033     130     197 ..     418     482 ..     337     485 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 1.3e-07
                 HCHHH.CCCGCCTCCHHHHHHHHHHHHHHHH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 130 esata.rllaselldlleeleeqvlaalaallpgelptvllHgDlhpgNllvdpddgrvtGviDfedag 197
                  ++++ +++ ++l+   +e+ +  +a   + l++  p+ l+H+Dl+pgN+l+d++ ++   v Df++++
  EFC35434.1 418 IAQCKcGRKNLDLKS-KIEILK-GIASGMDYLHSLKPRALIHRDLKPGNILLDSNLNPK--VCDFGLSK 482
                 567773334444444.555555.56666666777778****************888888..99999876 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   8.8e-07    0.0022     228     261 ..     455     488 ..     304     497 .. 0.63

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 8.8e-07
  Haspin_kinase 228 FEHRdLhldniLvdknlnvtlidlklsRlesseg 261
                    + HRdL+ +niL+d+nln  ++d+ ls+l+ss+g
     EFC35434.1 455 LIHRDLKPGNILLDSNLNPKVCDFGLSKLTSSSG 488
                    56***************************95544 PP

>> DUF2258  Uncharacterized protein conserved in archaea (DUF2258)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   4.4e-05      0.11      33      75 ..     180     223 ..     171     226 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 4.4e-05
                 .HHHHHHHHHHHHHHHHHHHHCCTT-.-TTSEEEEEEEEEEETT CS
     DUF2258  33 ekkeiaraiaeLNkklYevlveklki.dKldvvrirveyeveek 75 
                 +++++ +++   N +++++++++ k+ dK+++v+++v++  ++ 
  EFC35434.1 180 THRIVTNSLDLYNNTVFNIFIQNTKLtDKQELVNVTVQFVDRDF 223
                 455566666666************9659**********988775 PP

>> Fructosamin_kin  Fructosamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0    0.0001      0.27      21      97 ..     335     412 ..     322     426 .. 0.75
   2 ?   -1.0   0.0       0.3   7.8e+02     165     212 ..     428     477 ..     416     478 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.0001
  Fructosamin_kin  21 eaekveggeineayllseeeqrfFvklne....kealemFeaEaesLealaetqtirvPkvlavGelkdasfLvleyLelk 97 
                        ++++ g + + +l + +e+++ +k  +    + + + Fe+Ea  L+ l++ + +   + + v  +++++++v+eyLe +
       EFC35434.1 335 IVKRIGEGAMGTVFLANWNETKVALKSIKtessEISNDEFEHEASLLNSLRHPSIV---RFYGVTLSNTNKYMVVEYLENG 412
                      55677888888888888888888887665222344556799999999999665554...68999999***********988 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.3
  Fructosamin_kin 165 lefakieelvervaells.khqpkp.sllHGdLWsgNaaltkdgepvifd 212
                      l+ ++  e+++ +a+ +   h+ kp +l+H dL  gN+ l+++ +p ++d
       EFC35434.1 428 LDLKSKIEILKGIASGMDyLHSLKPrALIHRDLKPGNILLDSNLNPKVCD 477
                      5555555555555554431244455489**********999886676665 PP

>> DUF4436  Domain of unknown function (DUF4436)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1   5.6e-05      0.14     119     191 ..     205     284 ..     186     292 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 5.6e-05
     DUF4436 119 agsdaapvpvrveltgrlegwdltvkrseea...dkaaavevtlaRskstl....ifalvivlvlialpvlalivaiqvl 191
                  +++++ v+v v++++r+ ++++ ++ ++ +   + +  + v + +++  +    +f+ +i+lvl++++++  i  +q+l
  EFC35434.1 205 LTDKQELVNVTVQFVDRDFSFKIGIQVEKCPfdySIDTSTGVCVFKAHTAIilaaVFGFTILLVLLIIGIVSCIKIVQTL 284
                 3678899********************99989885555556666666655411226888899999999988887777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (644 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1004  (0.0559987); expected 358.6 (0.02)
Passed bias filter:                      624  (0.0348039); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.71u 0.35s 00:00:01.06 Elapsed: 00:00:00.49
# Mc/sec: 3956.71
//
Query:       EFC35435.1  [L=592]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.2e-93  298.0  34.0      6e-07   29.0   0.1   19.2 19  LRR_6       Leucine Rich repeat
    6.2e-56  186.0  16.8    1.2e-08   34.6   0.2    7.9  7  LRR_8       Leucine rich repeat
    2.1e-51  171.0  29.7     0.0001   22.6   0.2   11.6 13  LRR_4       Leucine Rich repeats (2 copies)
    2.8e-31  103.2   0.3        2.7    8.9   0.0   18.0 20  LRR_1       Leucine Rich Repeat
    3.3e-10   39.7   4.1      0.045   13.3   0.0    5.7  6  LRR_9       Leucine-rich repeat
    5.8e-06   26.2   4.5         10    6.0   0.0    8.6  8  DUF4347     Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
      0.011   15.6   5.7      0.011   15.6   5.7    4.9  5  Beta_helix  Right handed beta helix region
          4    7.2   9.7         44    3.8   0.2    4.7  5  DUF5612     Domain of unknown function (DUF5612)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   9.8e-06     0.022       5      24 .]     135     154 ..     132     154 .. 0.93
   2 !   13.2   0.1   3.1e-05     0.069       5      24 .]     159     178 ..     156     178 .. 0.93
   3 !   29.0   0.1   2.7e-10     6e-07       3      24 .]     181     202 ..     179     202 .. 0.94
   4 !   11.1   0.0   0.00015      0.34       5      23 ..     207     225 ..     205     226 .. 0.89
   5 !   18.4   0.0   6.8e-07    0.0015       5      24 .]     231     250 ..     228     250 .. 0.92
   6 !    7.6   0.0     0.002       4.6       5      19 ..     255     269 ..     252     274 .. 0.86
   7 !   18.0   0.1   9.2e-07    0.0021       5      24 .]     279     298 ..     276     298 .. 0.93
   8 !   22.4   0.2   3.6e-08   8.1e-05       5      24 .]     303     322 ..     300     322 .. 0.92
   9 !   17.4   0.0   1.4e-06    0.0031       5      24 .]     327     346 ..     324     346 .. 0.93
  10 !   12.3   0.0   6.1e-05      0.14       5      24 .]     351     370 ..     348     370 .. 0.93
  11 !   14.8   0.0   9.8e-06     0.022       5      23 ..     375     393 ..     372     394 .. 0.91
  12 !   17.1   0.0   1.7e-06    0.0039       5      23 ..     399     417 ..     397     418 .. 0.92
  13 !   12.8   0.0   4.2e-05     0.094       5      24 .]     423     442 ..     420     442 .. 0.92
  14 !   24.2   0.0   9.7e-09   2.2e-05       5      24 .]     447     466 ..     444     466 .. 0.93
  15 !   11.1   0.0   0.00015      0.34       5      23 ..     471     489 ..     469     490 .. 0.89
  16 !   17.5   0.0   1.3e-06    0.0029       5      24 .]     495     514 ..     492     514 .. 0.93
  17 !   19.1   0.0     4e-07    0.0009       5      23 ..     519     537 ..     516     538 .. 0.91
  18 !   20.0   0.0   2.2e-07   0.00048       5      23 ..     543     561 ..     540     562 .. 0.91
  19 ?    1.9   0.0      0.13     3e+02       5      18 ..     567     580 ..     564     581 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 9.8e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt++d+sgN Ig eGa++++
  EFC35435.1 135 LTSVDISGNRIGIEGAKSIS 154
                 9****************996 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.1e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s N Ig eGa++++
  EFC35435.1 159 LTSLNISNNIIGVEGAKSIS 178
                 9****************996 PP

  == domain 3  score: 29.0 bits;  conditional E-value: 2.7e-10
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  hLt+Ld+sgN IgDeG+++++
  EFC35435.1 181 KHLTSLDISGNRIGDEGVKSIS 202
                 6******************996 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00015
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L +Ld+s N Ig+eGa+ +
  EFC35435.1 207 LISLDISTNVIGGEGAKFI 225
                 669*************977 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 6.8e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+ +N Ig+eGa+ ++
  EFC35435.1 231 LTSLDIFYNRIGGEGAKLIS 250
                 9****************985 PP

  == domain 6  score: 7.6 bits;  conditional E-value: 0.002
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt+L++s N+I+ eG
  EFC35435.1 255 LTSLNISTNEIDVEG 269
                 9***********999 PP

  == domain 7  score: 18.0 bits;  conditional E-value: 9.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++sgN Ig eG+++++
  EFC35435.1 279 LTSLNISGNLIGVEGVKSIS 298
                 9****************996 PP

  == domain 8  score: 22.4 bits;  conditional E-value: 3.6e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++sgN IgDeGa+ ++
  EFC35435.1 303 LTSLNISGNLIGDEGAKLIS 322
                 9****************985 PP

  == domain 9  score: 17.4 bits;  conditional E-value: 1.4e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+  N IgDeG+++++
  EFC35435.1 327 LTSLDIYNNRIGDEGVKSIS 346
                 9****************996 PP

  == domain 10  score: 12.3 bits;  conditional E-value: 6.1e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+ d+s N I DeGa++++
  EFC35435.1 351 LTSFDISNNLIYDEGAKSIS 370
                 9****************996 PP

  == domain 11  score: 14.8 bits;  conditional E-value: 9.8e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L +s N Ig+eG++ +
  EFC35435.1 375 LTSLTISNNRIGGEGVKFI 393
                 9***************977 PP

  == domain 12  score: 17.1 bits;  conditional E-value: 1.7e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++s N+I++eGa+ +
  EFC35435.1 399 LTSLNISKNEIDGEGAKFI 417
                 9***************977 PP

  == domain 13  score: 12.8 bits;  conditional E-value: 4.2e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L +  N+IgDeG+++++
  EFC35435.1 423 LTSLTIYKNGIGDEGVKSIS 442
                 9999999**********996 PP

  == domain 14  score: 24.2 bits;  conditional E-value: 9.7e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s N IgDeG+++++
  EFC35435.1 447 LTSLDISNNRIGDEGVKSIS 466
                 9****************996 PP

  == domain 15  score: 11.1 bits;  conditional E-value: 0.00015
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L +Ld+s N Ig+eGa+ +
  EFC35435.1 471 LISLDISTNVIGGEGAKFI 489
                 669*************977 PP

  == domain 16  score: 17.5 bits;  conditional E-value: 1.3e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+sgN I DeG+++++
  EFC35435.1 495 LTSLDISGNLIYDEGVKSIS 514
                 9****************996 PP

  == domain 17  score: 19.1 bits;  conditional E-value: 4e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++sgN+Ig eGa+ +
  EFC35435.1 519 LTSLNISGNQIGVEGAKFI 537
                 9***************977 PP

  == domain 18  score: 20.0 bits;  conditional E-value: 2.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+s N+IgD+Ga+ +
  EFC35435.1 543 LTSLDISKNEIGDAGAKFI 561
                 9***************977 PP

  == domain 19  score: 1.9 bits;  conditional E-value: 0.13
       LRR_6   5 LteLdLsgNdIgDe 18 
                 Lt+Ld+  N I+De
  EFC35435.1 567 LTSLDVYANRISDE 580
                 9***********98 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   3.7e-07   0.00082      18      59 ..     126     167 ..     125     169 .. 0.94
   2 !   27.7   0.0   7.5e-10   1.7e-06       2      61 .]     182     241 ..     181     241 .. 0.98
   3 !   33.9   1.4   8.8e-12     2e-08       2      61 .]     254     313 ..     252     313 .. 0.98
   4 !   34.6   0.2   5.2e-12   1.2e-08       2      61 .]     326     385 ..     325     385 .. 0.98
   5 !   28.7   0.2   3.7e-10   8.2e-07       2      61 .]     398     457 ..     397     457 .. 0.98
   6 !   31.3   0.1   5.6e-11   1.3e-07       2      61 .]     446     505 ..     445     505 .. 0.98
   7 !   28.5   0.0   4.2e-10   9.5e-07       2      61 .]     518     577 ..     517     577 .. 0.97

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 3.7e-07
                 TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  18 deaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +++ +g+++L++ d+s N++    ++++s +++L+sL++s+N
  EFC35435.1 126 PKFISGMKQLTSVDISGNRIGIEGAKSISEMKQLTSLNISNN 167
                 67889************************************9 PP

  == domain 2  score: 27.7 bits;  conditional E-value: 7.5e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+s Nr+ + + ++ + +++L +Ld+s N +    ++ +s +++L+sLd+ +Nr+
  EFC35435.1 182 HLTSLDISGNRIGDEGVKSISEMEQLISLDISTNVIGGEGAKFISEMKQLTSLDIFYNRI 241
                 8*********************************************************97 PP

  == domain 3  score: 33.9 bits;  conditional E-value: 8.8e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++s N + + + +  + +++L++L++s Nl+ +   +++sg+++L+sL++sgN +
  EFC35435.1 254 QLTSLNISTNEIDVEGSKLISEMKQLTSLNISGNLIGVEGVKSISGMKQLTSLNISGNLI 313
                 7*********************************************************87 PP

  == domain 4  score: 34.6 bits;  conditional E-value: 5.2e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+ nNr+ + + ++ + +++L+++d+snNl+    ++++sg+++L+sL++s+Nr+
  EFC35435.1 326 QLTSLDIYNNRIGDEGVKSISEMKQLTSFDISNNLIYDEGAKSISGMKQLTSLTISNNRI 385
                 7*********************************************************98 PP

  == domain 5  score: 28.7 bits;  conditional E-value: 3.7e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++s+N + + + ++ +g+++L++L +  N +     +++s +++L+sLd+s+Nr+
  EFC35435.1 398 QLTSLNISKNEIDGEGAKFISGMKQLTSLTIYKNGIGDEGVKSISEMKQLTSLDISNNRI 457
                 7*********************************************************98 PP

  == domain 6  score: 31.3 bits;  conditional E-value: 5.6e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+snNr+ + + ++ + +++L +Ld+s N +    ++ +s +++L+sLd+sgN +
  EFC35435.1 446 QLTSLDISNNRIGDEGVKSISEMEQLISLDISTNVIGGEGAKFISEMKQLTSLDISGNLI 505
                 7*********************************************************87 PP

  == domain 7  score: 28.5 bits;  conditional E-value: 4.2e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++s N++ + + ++ + +++L++Ld+s N++    ++ +s +++L+sLd+  Nr+
  EFC35435.1 518 QLTSLNISGNQIGVEGAKFISEMKQLTSLDISKNEIGDAGAKFISEMKQLTSLDVYANRI 577
                 7******************************************************99987 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.1   2.3e-07   0.00051       1      36 [.     133     169 ..     133     179 .. 0.81
   2 !   16.4   0.0     4e-06    0.0091       1      33 [.     181     215 ..     181     219 .. 0.87
   3 !   19.1   0.1   5.7e-07    0.0013       1      39 [.     229     267 ..     229     274 .. 0.84
   4 !   22.2   0.5   6.2e-08   0.00014       1      38 [.     277     315 ..     277     322 .. 0.84
   5 !   22.6   0.2   4.5e-08    0.0001       1      37 [.     325     362 ..     325     371 .. 0.84
   6 !   17.8   0.4   1.4e-06    0.0032       1      36 [.     349     385 ..     349     395 .. 0.87
   7 !   18.1   0.5   1.2e-06    0.0027       1      40 [.     373     410 ..     373     413 .. 0.86
   8 !   14.2   0.1     2e-05     0.045       1      37 [.     397     434 ..     397     442 .. 0.84
   9 !   18.0   0.1   1.3e-06    0.0028       1      38 [.     421     459 ..     421     466 .. 0.84
  10 !   18.5   0.2   8.6e-07    0.0019       1      33 [.     445     479 ..     445     483 .. 0.87
  11 !   13.1   0.1   4.6e-05       0.1       2      36 ..     470     505 ..     469     511 .. 0.81
  12 !   20.5   0.2     2e-07   0.00046       1      36 [.     493     529 ..     493     538 .. 0.82
  13 !   19.9   0.0   3.2e-07   0.00072       1      38 [.     541     579 ..     541     589 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 2.3e-07
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 ++L+++d+s+N++  i++   ++ +++L++L++s+N  i
  EFC35435.1 133 KQLTSVDISGNRIG-IEGaksISEMKQLTSLNISNN-II 169
                 58************.777565335*********666.44 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 4e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 ++L++Ld+s+N++ d +   ++ + +L +Ld+s N
  EFC35435.1 181 KHLTSLDISGNRIGDEGVksISEMEQLISLDISTN 215
                 68************999986445*********888 PP

  == domain 3  score: 19.1 bits;  conditional E-value: 5.7e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdl 39 
                 ++L++Ld++ N++   +  l + +++L++L++s N  i d+
  EFC35435.1 229 KQLTSLDIFYNRIGGEGAkLISeMKQLTSLNISTN-EI-DV 267
                 58************988896655*********888.66.54 PP

  == domain 4  score: 22.2 bits;  conditional E-value: 6.2e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++s+N +   +   ++++++L++L++sgN li+d
  EFC35435.1 277 KQLTSLNISGNLIGVEGVksISGMKQLTSLNISGN-LIGD 315
                 58********9*88655575557***********9.8876 PP

  == domain 5  score: 22.6 bits;  conditional E-value: 4.5e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++Ld+ nN++ d +   ++ +++L+++d+ +Nnli 
  EFC35435.1 325 KQLTSLDIYNNRIGDEGVksISEMKQLTSFDI-SNNLIY 362
                 58************999986445*********.555885 PP

  == domain 6  score: 17.8 bits;  conditional E-value: 1.4e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++ d+snN + d +   ++++++L++L++s+N +i
  EFC35435.1 349 KQLTSFDISNNLIYDEGAksISGMKQLTSLTISNN-RI 385
                 58*************99987668*********555.77 PP

  == domain 7  score: 18.1 bits;  conditional E-value: 1.2e-06
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdld 40 
                 ++L++L +snN++   +  + + +++L++L++s N     +d
  EFC35435.1 373 KQLTSLTISNNRIGGEGVkFISeIKQLTSLNISKN----EID 410
                 58************877786655*********999....554 PP

  == domain 8  score: 14.2 bits;  conditional E-value: 2e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L++s N +   +   ++++++L++L++  N  i+
  EFC35435.1 397 KQLTSLNISKNEIDGEGAkfISGMKQLTSLTIYKN-GIG 434
                 58************988895446*********777.665 PP

  == domain 9  score: 18.0 bits;  conditional E-value: 1.3e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L +  N + d +   ++ +++L++Ld+ +Nn+i+d
  EFC35435.1 421 KQLTSLTIYKNGIGDEGVksISEMKQLTSLDI-SNNRIGD 459
                 589*********99988886445*********.6669876 PP

  == domain 10  score: 18.5 bits;  conditional E-value: 8.6e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 ++L++Ld+snN++ d +   ++ + +L +Ld+s N
  EFC35435.1 445 KQLTSLDISNNRIGDEGVksISEMEQLISLDISTN 479
                 58************999986445*********888 PP

  == domain 11  score: 13.1 bits;  conditional E-value: 4.6e-05
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 +L++Ld+s N +   +  + + +++L++Ld+sgN li
  EFC35435.1 470 QLISLDISTNVIGGEGAkFISeMKQLTSLDISGN-LI 505
                 6999****55888877796655***********9.66 PP

  == domain 12  score: 20.5 bits;  conditional E-value: 2e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++Ld+s+N + d +   ++ +++L++L++sgN +i
  EFC35435.1 493 KQLTSLDISGNLIYDEGVksISEMKQLTSLNISGN-QI 529
                 58**********77766654333************.66 PP

  == domain 13  score: 19.9 bits;  conditional E-value: 3.2e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++Ld+s N + d +  + + +++L++Ld+  N +i+d
  EFC35435.1 541 KQLTSLDISKNEIGDAGAkFISeMKQLTSLDVYAN-RISD 579
                 58*************999*6655*********667.7765 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1       2.1   4.7e+03       7      16 ..      65      74 ..      58      79 .. 0.78
   2 ?    2.9   0.0      0.11   2.4e+02       2      17 ..     135     150 ..     134     156 .. 0.75
   3 !    8.7   0.0    0.0014         3       1      22 [.     158     179 ..     158     180 .. 0.87
   4 !    8.3   0.0    0.0018       4.1       1      21 [.     182     202 ..     182     204 .. 0.87
   5 ?    0.2   0.0      0.86   1.9e+03       2      17 ..     207     222 ..     206     228 .. 0.76
   6 ?    2.5   0.0      0.15   3.4e+02       1      18 [.     230     247 ..     230     252 .. 0.80
   7 ?    1.6   0.0       0.3   6.8e+02       1      17 [.     254     270 ..     254     276 .. 0.74
   8 ?    5.8   0.0     0.012        28       1      21 [.     278     298 ..     278     300 .. 0.83
   9 ?    5.1   0.0     0.021        48       1      17 [.     302     318 ..     302     324 .. 0.79
  10 !    6.2   0.0    0.0095        21       1      21 [.     326     346 ..     326     348 .. 0.87
  11 ?    2.2   0.0      0.19   4.3e+02       2      21 ..     351     370 ..     350     372 .. 0.78
  12 ?    3.3   0.0     0.081   1.8e+02       1      16 [.     374     389 ..     374     395 .. 0.80
  13 ?    4.4   0.0     0.035        78       1      20 [.     398     417 ..     398     420 .. 0.80
  14 ?   -1.5   0.0       3.1   6.9e+03       2      21 ..     423     442 ..     422     444 .. 0.83
  15 !    8.9   0.0    0.0012       2.7       1      21 [.     446     466 ..     446     468 .. 0.87
  16 ?    0.2   0.0      0.86   1.9e+03       2      17 ..     471     486 ..     470     492 .. 0.76
  17 ?    4.4   0.0     0.035        78       1      18 [.     494     511 ..     494     516 .. 0.74
  18 ?    5.8   0.0     0.013        28       1      15 [.     518     532 ..     518     540 .. 0.78
  19 ?    3.4   0.0     0.078   1.7e+02       1      14 [.     542     555 ..     542     564 .. 0.78
  20 ?   -2.6   0.0       7.2   1.6e+04       2      12 ..     567     577 ..     566     581 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 2.1
       LRR_1  7 Lsnnpllglp 16
                L+n++l++++
  EFC35435.1 65 LNNCSLISKQ 74
                8999997665 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.11
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L++ d+s+n+++  ++
  EFC35435.1 135 LTSVDISGNRIGIEGA 150
                 99********955555 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0014
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L++snn+++  ++ s+++
  EFC35435.1 158 QLTSLNISNNIIGVEGAKSISG 179
                 599*********9999888875 PP

  == domain 4  score: 8.3 bits;  conditional E-value: 0.0018
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld+s+n++++ +  s++
  EFC35435.1 182 HLTSLDISGNRIGDEGVKSIS 202
                 69**********999988876 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.86
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L +Ld+s n ++g ++
  EFC35435.1 207 LISLDISTNVIGGEGA 222
                 899****998877665 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.15
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld+ +n+++g ++ 
  EFC35435.1 230 QLTSLDIFYNRIGGEGAK 247
                 599********9877665 PP

  == domain 7  score: 1.6 bits;  conditional E-value: 0.3
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++s n ++  ++
  EFC35435.1 254 QLTSLNISTNEIDVEGS 270
                 599*****999855544 PP

  == domain 8  score: 5.8 bits;  conditional E-value: 0.012
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++s+n ++  +  s++
  EFC35435.1 278 QLTSLNISGNLIGVEGVKSIS 298
                 599*******99888877776 PP

  == domain 9  score: 5.1 bits;  conditional E-value: 0.021
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++s+n +++ ++
  EFC35435.1 302 QLTSLNISGNLIGDEGA 318
                 599*******9977665 PP

  == domain 10  score: 6.2 bits;  conditional E-value: 0.0095
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld+ nn++++ +  s++
  EFC35435.1 326 QLTSLDIYNNRIGDEGVKSIS 346
                 599*********999988876 PP

  == domain 11  score: 2.2 bits;  conditional E-value: 0.19
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L++ d+snn + + ++ s++
  EFC35435.1 351 LTSFDISNNLIYDEGAKSIS 370
                 999******98777777665 PP

  == domain 12  score: 3.3 bits;  conditional E-value: 0.081
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L +snn+++g +
  EFC35435.1 374 QLTSLTISNNRIGGEG 389
                 599********97765 PP

  == domain 13  score: 4.4 bits;  conditional E-value: 0.035
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++s n ++g ++  +
  EFC35435.1 398 QLTSLNISKNEIDGEGAKFI 417
                 599********988777665 PP

  == domain 14  score: -1.5 bits;  conditional E-value: 3.1
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L++L +  n +++ +  s++
  EFC35435.1 423 LTSLTIYKNGIGDEGVKSIS 442
                 999*9*99999888888876 PP

  == domain 15  score: 8.9 bits;  conditional E-value: 0.0012
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld+snn++++ +  s++
  EFC35435.1 446 QLTSLDISNNRIGDEGVKSIS 466
                 599*********999988876 PP

  == domain 16  score: 0.2 bits;  conditional E-value: 0.86
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L +Ld+s n ++g ++
  EFC35435.1 471 LISLDISTNVIGGEGA 486
                 899****998877665 PP

  == domain 17  score: 4.4 bits;  conditional E-value: 0.035
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld+s+n + + +  
  EFC35435.1 494 QLTSLDISGNLIYDEGVK 511
                 599*******88555555 PP

  == domain 18  score: 5.8 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L++s+n+++  
  EFC35435.1 518 QLTSLNISGNQIGVE 532
                 599*******99655 PP

  == domain 19  score: 3.4 bits;  conditional E-value: 0.078
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++Ld+s n +++
  EFC35435.1 542 QLTSLDISKNEIGD 555
                 599*******9865 PP

  == domain 20  score: -2.6 bits;  conditional E-value: 7.2
       LRR_1   2 LrhLdLsnnpl 12 
                 L++Ld+  n++
  EFC35435.1 567 LTSLDVYANRI 577
                 999**977765 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.0   0.0    0.0068        15      42     124 ..     133     216 ..      98     241 .. 0.67
   2 !    4.8   0.1    0.0078        18      61     123 ..     226     287 ..     202     293 .. 0.77
   3 !    7.3   0.6    0.0014       3.1      39     123 ..     274     359 ..     246     368 .. 0.60
   4 !   13.3   0.0     2e-05     0.045      43     126 ..     350     434 ..     346     451 .. 0.84
   5 ?    2.3   0.0     0.047     1e+02      62     119 ..     443     499 ..     436     506 .. 0.61
   6 !    9.3   0.0   0.00033      0.74      42     128 ..     493     580 ..     477     586 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0068
       LRR_9  42 dqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                  q+ ++d+s n i      ++  +k+l +l ++nn i   + +    + +l++l +++n++ + + ++ + ++++l +l + +n 
  EFC35435.1 133 KQLTSVDISGNRIgiEGAKSISEMKQLTSLNISNNIIGVEGAKSISGMKHLTSLDISGNRIGDEG-VKSISEMEQLISLDISTNV 216
                 56667777777542145566667777777777777776666666666677777777777776644.3555555555555554444 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0078
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                   +k+l +l +  nri   + +l   + +l++l ++ ne++  +  + + ++k+l++l +  n
  EFC35435.1 226 SEMKQLTSLDIFYNRIGGEGAKLISEMKQLTSLNISTNEIDVEGS-KLISEMKQLTSLNISGN 287
                 4588899999999*************************9986666.77889999999988766 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0014
       LRR_9  39 atldqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                 + + q+ ++++s n i    + ++  +k+l +l ++ n i   + +l   + +l++l + nn++ + + ++ + ++k+l+++ + +n
  EFC35435.1 274 SEMKQLTSLNISGNLIgvEGVKSISGMKQLTSLNISGNLIGDEGAKLISEMKQLTSLDIYNNRIGDEG-VKSISEMKQLTSFDISNN 359
                 34556666666666442245666666777777777777777777777777777777777777777754.467777777776666555 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 2e-05
       LRR_9  43 qfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 q+ + d+s+n i +    ++  +k+l +l ++nnri   + ++   + +l++l +++ne++  +  + +  +k+l++l++ kn + 
  EFC35435.1 350 QLTSFDISNNLIYDegAKSISGMKQLTSLTISNNRIGGEGVKFISEIKQLTSLNISKNEIDGEGA-KFISGMKQLTSLTIYKNGIG 434
                 66777788887765224667889**************99999999***************98877.8999**********999875 PP

  == domain 5  score: 2.3 bits;  conditional E-value: 0.047
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklells 119
                  +k+l +l ++nnri   + +    + +l +l ++ n +   +  + + ++k+l++l 
  EFC35435.1 443 EMKQLTSLDISNNRIGDEGVKSISEMEQLISLDISTNVIGGEGA-KFISEMKQLTSLD 499
                 68999999999999865444433444444445456666655444.5566666666665 PP

  == domain 6  score: 9.3 bits;  conditional E-value: 0.00033
       LRR_9  42 dqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                  q+ ++d+s n i +  + ++  +k+l +l ++ n+i   + ++   + +l++l +++ne+ + +  + + ++k+l++l +  n ++++
  EFC35435.1 493 KQLTSLDISGNLIYDegVKSISEMKQLTSLNISGNQIGVEGAKFISEMKQLTSLDISKNEIGDAGA-KFISEMKQLTSLDVYANRISDE 580
                 678888999998864338889999*************9999999999****************988.999*********9999998865 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       2.1   4.6e+03     109     123 ..     128     142 ..     126     171 .. 0.58
   2 ?    0.9   0.0      0.16   3.6e+02     104     121 ..     219     236 ..     213     240 .. 0.86
   3 ?   -0.0   0.0      0.32   7.1e+02     104     124 ..     243     263 ..     239     275 .. 0.85
   4 ?   -0.8   0.0      0.55   1.2e+03     105     122 ..     268     285 ..     265     294 .. 0.85
   5 ?    0.8   0.0      0.17   3.9e+02     103     122 ..     314     333 ..     311     342 .. 0.88
   6 ?    2.4   0.0     0.056   1.3e+02      86     121 ..     419     452 ..     386     470 .. 0.52
   7 ?    1.8   0.0     0.085   1.9e+02     104     122 ..     483     501 ..     464     504 .. 0.87
   8 !    6.0   0.0    0.0045        10     103     124 ..     554     575 ..     506     578 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.1
     DUF4347 109 fvekLaqltgadvaA 123
                 f++ ++qlt +d++ 
  EFC35435.1 128 FISGMKQLTSVDISG 142
                 555566666655543 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.16
     DUF4347 104 eaGeafvekLaqltgadv 121
                  +G +f+++++qlt  d+
  EFC35435.1 219 GEGAKFISEMKQLTSLDI 236
                 479************998 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.32
     DUF4347 104 eaGeafvekLaqltgadvaAs 124
                  +G +++++++qlt  +++ +
  EFC35435.1 243 GEGAKLISEMKQLTSLNISTN 263
                 4799************99865 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 0.55
     DUF4347 105 aGeafvekLaqltgadva 122
                 +G++++++++qlt  +++
  EFC35435.1 268 EGSKLISEMKQLTSLNIS 285
                 799***********9996 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.17
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +++++++qlt  d+ 
  EFC35435.1 314 GDEGAKLISEMKQLTSLDIY 333
                 689*************9996 PP

  == domain 6  score: 2.4 bits;  conditional E-value: 0.056
     DUF4347  86 alsedadillYgCnvAageaGeafvekLaqltgadv 121
                  +++   + +Y   ++  ++G + +++++qlt  d+
  EFC35435.1 419 GMKQLTSLTIYKNGIG--DEGVKSISEMKQLTSLDI 452
                 2333334444444333..346666666666666665 PP

  == domain 7  score: 1.8 bits;  conditional E-value: 0.085
     DUF4347 104 eaGeafvekLaqltgadva 122
                  +G +f+++++qlt  d++
  EFC35435.1 483 GEGAKFISEMKQLTSLDIS 501
                 47*************9996 PP

  == domain 8  score: 6.0 bits;  conditional E-value: 0.0045
     DUF4347 103 geaGeafvekLaqltgadvaAs 124
                 g+aG +f+++++qlt  dv A+
  EFC35435.1 554 GDAGAKFISEMKQLTSLDVYAN 575
                 5678888888888888888775 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.9       1.4   3.1e+03     102     114 ..      18      30 ..       5      68 .. 0.69
   2 ?    1.2   5.0      0.13   2.9e+02      55     132 ..     136     215 ..     101     263 .. 0.58
   3 ?    0.2   1.3      0.26   5.8e+02      74     133 ..     228     288 ..     185     297 .. 0.52
   4 ?   15.6   5.7   4.9e-06     0.011      51     135 ..     293     386 ..     240     399 .. 0.70
   5 ?    9.2   5.5   0.00044      0.99      35     157 ..     403     528 ..     386     582 .. 0.51

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.4
                 --EEES-EEESTT CS
  Beta_helix 102 nntienNiidnna 114
                   +++nN+ +nn+
  EFC35435.1  18 EEIFTNNNNNNNN 30 
                 3334444444443 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.13
                 -S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT---EEES- CS
  Beta_helix  55 snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdsssnvtvtnN 132
                 + + is+n+i   +  +   +++     i+nn i   g   i+ +   ++++i++N+i + +   i+ +++  ++ ++ N
  EFC35435.1 136 TSVDISGNRIGIEGaKSISEMKQLTSLNISNNIIGVEGAKSISGMkHLTSLDISGNRIGDEGVKSISEMEQLISLDISTN 215
                 45555555553333113333335555555555555555555544423555666666665555444444444433333333 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.26
                 TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT---EEES-E CS
  Beta_helix  74 lfgasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdsssnvtvtnNt 133
                 +++     i +n+i   g   i+ + + +++ i+ N id  +   i+ + + +++++++N 
  EFC35435.1 228 MKQLTSLDIFYNRIGGEGAKLISEMkQLTSLNISTNEIDVEGSKLISEMKQLTSLNISGNL 288
                 3333444455555555555555333245556666666666666666666665666666665 PP

  == domain 4  score: 15.6 bits;  conditional E-value: 4.9e-06
                 E-TT.......-S-EEES-EEE---SEEE-TT.--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT---EEES-EEE CS
  Beta_helix  51 ilgs.......snntisnntisdnngggialf.gasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdsssnvtvtnNtit 135
                   +s       +  +is+n i d ++  i  + +     i+nn+i d g   i+ + + ++ +i+nN i++ ++  i+ + + +++t++nN+i 
  EFC35435.1 293 GVKSisgmkqlTSLNISGNLIGDEGAKLISEMkQLTSLDIYNNRIGDEGVKSISEMkQLTSFDISNNLIYDEGAKSISGMKQLTSLTISNNRIG 386
                 2222444555788899999999999666666647777779999999999999966647888999999999999999999999999999999886 PP

  == domain 5  score: 9.2 bits;  conditional E-value: 0.00044
                 EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT---EEE CS
  Beta_helix  35 vienneiannsgsGiyilgs.snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdsssnvtvt 130
                  i++nei + +   i+  ++ +  ti++n i d +  +   +++     i+nn+i d g   i+ + +  +++i+ N+i + ++  i+ + + +++ ++
  EFC35435.1 403 NISKNEIDGEGAKFISGMKQlTSLTIYKNGIGDEGvKSISEMKQLTSLDISNNRIGDEGVKSISEMeQLISLDISTNVIGGEGAKFISEMKQLTSLDIS 501
                 344444444333333333334444444444444443333333344444455555555544444322123334444444444443333333333444444 PP

                 S-EEES-SSEEEE-TT-SS--EEES-E CS
  Beta_helix 131 nNtitnnkgaGiavvgsssnvtvrnNt 157
                 +N i++ + ++i  + + +++ +++N+
  EFC35435.1 502 GNLIYDEGVKSISEMKQLTSLNISGNQ 528
                 444444444444444444444444443 PP

>> DUF5612  Domain of unknown function (DUF5612)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.1      0.04        90      48     100 ..     187     239 ..     176     252 .. 0.84
   2 ?    3.8   0.2      0.02        44      48      97 ..     283     332 ..     259     343 .. 0.80
   3 ?   -0.8   0.0      0.52   1.2e+03      59      98 ..     366     405 ..     356     416 .. 0.81
   4 ?    0.9   0.1      0.16   3.6e+02      57      97 ..     460     500 ..     442     516 .. 0.85
   5 ?    1.3   0.0      0.12   2.7e+02      49      97 ..     500     548 ..     494     560 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.04
                 E--SHHHHHHHHHHGGGSTTEEEEEEESSB--THHHHHHHHHHHT.T-EEEEE CS
     DUF5612  48 plvGeeelaeaveavsrlprvkvlvlaGslmGGkiteavkklkeekdiivisl 100
                  + G++   e v+++s +++   l ++  ++GG+ ++ ++++k+ + + ++  
  EFC35435.1 187 DISGNRIGDEGVKSISEMEQLISLDISTNVIGGEGAKFISEMKQLTSLDIFYN 239
                 5666666678999******************************9998887755 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.02
                 E--SHHHHHHHHHHGGGSTTEEEEEEESSB--THHHHHHHHHHHT.T-EE CS
     DUF5612  48 plvGeeelaeaveavsrlprvkvlvlaGslmGGkiteavkklkeekdiiv 97 
                  + G+    e v+++s +++ + l ++G l+G + ++ ++++k+ + + +
  EFC35435.1 283 NISGNLIGVEGVKSISGMKQLTSLNISGNLIGDEGAKLISEMKQLTSLDI 332
                 55555555688999999999999999999999999999999998877665 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.52
                 HHHGGGSTTEEEEEEESSB--THHHHHHHHHHHT.T-EEE CS
     DUF5612  59 veavsrlprvkvlvlaGslmGGkiteavkklkeekdiivi 98 
                  +++s +++ + l ++   +GG+ ++ ++++k+ + + + 
  EFC35435.1 366 AKSISGMKQLTSLTISNNRIGGEGVKFISEIKQLTSLNIS 405
                 56788888889999999999***********999888765 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.16
                 HHHHHGGGSTTEEEEEEESSB--THHHHHHHHHHHT.T-EE CS
     DUF5612  57 eaveavsrlprvkvlvlaGslmGGkiteavkklkeekdiiv 97 
                 e v+++s +++   l ++  ++GG+ ++ ++++k+ + + +
  EFC35435.1 460 EGVKSISEMEQLISLDISTNVIGGEGAKFISEMKQLTSLDI 500
                 67999999999999999***************999866654 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.12
                 --SHHHHHHHHHHGGGSTTEEEEEEESSB--THHHHHHHHHHHT.T-EE CS
     DUF5612  49 lvGeeelaeaveavsrlprvkvlvlaGslmGGkiteavkklkeekdiiv 97 
                 + G+    e v+++s +++ + l ++G  +G + ++ ++++k+ + + +
  EFC35435.1 500 ISGNLIYDEGVKSISEMKQLTSLNISGNQIGVEGAKFISEMKQLTSLDI 548
                 5566666788999999999999999999999999999999998876654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (592 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       565  (0.0315132); expected 358.6 (0.02)
Passed bias filter:                      217  (0.0121033); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.55
# Mc/sec: 3250.84
//
Query:       EFC35436.1  [L=243]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2574  (0.143566); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 1515.83
//
Query:       EFC35437.1  [L=569]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      5e-29  101.0   7.1    1.2e-09   38.5   0.1    3.5  3  DOMON        DOMON domain
  ------ inclusion threshold ------
      0.021   15.1   1.6        4.6    7.6   0.1    3.1  3  WG_beta_rep  WG containing repeat


Domain annotation for each model (and alignments):
>> DOMON  DOMON domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.2   0.4   6.7e-13     6e-09      18     123 ..      43     148 ..      20     150 .. 0.82
   2 !   38.5   0.1   1.3e-13   1.2e-09      13     123 ..     248     360 ..     231     362 .. 0.81
   3 !   28.9   0.1   1.2e-10   1.1e-06      15      81 ..     494     560 ..     475     567 .. 0.81

  Alignments for each domain:
  == domain 1  score: 36.2 bits;  conditional E-value: 6.7e-13
       DOMON  18 iefelsgkvntngyvaiGfsd.dgk.Msnadvvvgwvd.ngrvyvqdyystggkgapriddtgsqditlls..gseengvttlkfrRkldtcdpkqdnk 111
                 +ef + + +nt+gyv++ f+  +g  M+++ +   +++ ++ v+++d ++  + ++p++d   s+di + +  + +  g t++k +R ++t+d+ +d  
  EFC35437.1  43 LEFGAVA-KNTRGYVSFCFGYlNGDpMKGDTIFGYYNSaSQSVTIMDAWMVAKPQSPVSDA--SDDILQRNggYNSATGETHIKWTRFVKTGDS-HDVI 137
                 6788885.568**********9555499988888888866*********7777777****5..5***999955666789**************9.**99 PP

       DOMON 112 idldttvyviwa 123
                 + ++  ++  wa
  EFC35437.1 138 F-TNAVMKTSWA 148
                 9.9999999998 PP

  == domain 2  score: 38.5 bits;  conditional E-value: 1.3e-13
       DOMON  13 gdgdeiefelsgkvnt.ngyvaiGfsd..dgkMsnadvvvgwvdn.grvyvqdyystggkgapriddtgsqditlls....gseengvttlkfrRkldt 103
                 +++  ief l   ++   gy ++Gf +  +++M  ad ++g+vd+ g+v + d y++g+ +ap++d++  qd+ + +      + n  ++lk +R ++t
  EFC35437.1 248 ANNPIIEFGLL--ATGiYGYASLGFNHgaSSGMQTADTMFGYVDStGKVVIVDAYMQGNLQAPTLDSS--QDFISKNgglrSVSGNYELHLKWTRLVNT 342
                 56778999999..44349*********99999************66********************77..66666553433455677899********* PP

       DOMON 104 cdpkqdnkidldttvyviwa 123
                  d+  d+++ ++ ++ + wa
  EFC35437.1 343 MDS-ADQAF-TNVQIPISWA 360
                 **9.*****.9999999998 PP

  == domain 3  score: 28.9 bits;  conditional E-value: 1.2e-10
       DOMON  15 gdeiefelsgkvnt.ngyvaiGfsd..dgkMsnadvvvgwvdn.grvyvqdyystggkgapriddtgsqdi 81 
                    ief l   ++   gy +iGf +  +++M+ ad ++g+vd+ g++ + d+y++g+ +ap++d++  qd+
  EFC35437.1 494 VPIIEFGLI--ATGiYGYASIGFNHgtNSGMDTADTMFGYVDStGKAVILDTYMQGNLQAPTLDSS--QDF 560
                 456888888..44349********998889************66********************77..887 PP

>> WG_beta_rep  WG containing repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.1   0.00051       4.6       1      12 [.     285     296 ..     285     299 .. 0.94
   2 ?   -3.3   0.0       1.3   1.2e+04       7      13 ..     419     425 ..     418     426 .. 0.87
   3 ?    5.6   0.0    0.0022        20       1      14 [.     529     542 ..     529     544 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00051
  WG_beta_rep   1 yGyiDknGkivi 12 
                  +Gy+D++Gk+vi
   EFC35437.1 285 FGYVDSTGKVVI 296
                  6*********98 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.3
  WG_beta_rep   7 nGkivip 13 
                  nG++v+p
   EFC35437.1 419 NGNVVTP 425
                  8****98 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0022
  WG_beta_rep   1 yGyiDknGkivipp 14 
                  +Gy+D++Gk vi  
   EFC35437.1 529 FGYVDSTGKAVILD 542
                  6********99955 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (569 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       361  (0.020135); expected 358.6 (0.02)
Passed bias filter:                      247  (0.0137766); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 3459.92
//
Query:       EFC35438.1  [L=660]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (660 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1316  (0.0734006); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.51
# Mc/sec: 3909.19
//
Query:       EFC35439.1  [L=277]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.018   15.3  12.0       0.55   10.6   0.0    4.8  5  Kelch_6   Kelch motif
      0.079   13.5   2.7         27    5.4   0.0    3.7  3  PQQ_3     PQQ-like domain


Domain annotation for each model (and alignments):
>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.1    0.0025        23      11      44 ..      11      45 ..       6      54 .. 0.86
   2 ?   10.6   0.0   6.1e-05      0.55      10      40 ..      57      89 ..      47      92 .. 0.90
   3 ?    3.5   0.3      0.01        92       6      28 ..     101     126 ..      97     141 .. 0.69
   4 ?    0.1   0.2      0.13   1.1e+03       7      23 ..     163     180 ..     158     215 .. 0.69
   5 ?   -1.8   0.0      0.51   4.6e+03      33      42 ..     228     237 ..     226     240 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0025
     Kelch_6 11 ggkiYifGGytds.spylnkvwvydpetksWeqlp 44
                + ++++ G  + + + ++n +  +++e k+W +l+
  EFC35439.1 11 NKYLFVSGTFNRAgDLWVNGLAYWNIEKKTWNKLE 45
                4599*******99******************9876 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 6.1e-05
     Kelch_6 10 vgg.kiYifGGytds.spylnkvwvydpetksW 40
                ++g ++Y++G +t +    ++   ++d+e+ +W
  EFC35439.1 57 YDGrYLYVVGSLTRAgKYVVKNAARFDMESQTW 89
                56669***********9999999********** PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.01
     Kelch_6   6 sl.vsvggkiYifGGytds..spyln 28 
                 s+ v+v+gk++++G +++s  s ++n
  EFC35439.1 101 SVgVVVDGKFVAWGSNGGSgvSFWQN 126
                 55699*********999965544444 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.13
     Kelch_6   7 lvs.vggkiYifGGytds 23 
                 +v+   gkiY ++  t +
  EFC35439.1 163 AVTyFKGKIYFLSAGTVY 180
                 555567788877777664 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 0.51
     Kelch_6  33 ydpetksWeq 42 
                 y+++tk++++
  EFC35439.1 228 YNIDTKNIQH 237
                 9*****9998 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0    0.0031        27       5      29 ..      41      67 ..      38      86 .. 0.70
   2 ?    1.8   0.1      0.04   3.6e+02      14      31 ..      96     117 ..      87     118 .. 0.75
   3 ?    4.1   0.1     0.008        72      20      35 ..     175     193 ..     158     195 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0031
       PQQ_3  5 Wsv.qlpg.pvnsspavdgglvyvgtg 29
                W++ ++ + +  s   +dg+++yv+++
  EFC35439.1 41 WNKlETNSmDSISDIDYDGRYLYVVGS 67
                55556666666677789********97 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.04
       PQQ_3  14 nssp....avdgglvyvgtgdG 31 
                  ssp    +v++g+ ++ +++G
  EFC35439.1  96 LSSPasvgVVVDGKFVAWGSNG 117
                 4666677889999999988887 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.008
       PQQ_3  20 dgglvyvgtg...dGtlyA 35 
                 + g+vyv+++    GtlyA
  EFC35439.1 175 SAGTVYVSDTsmsKGTLYA 193
                 5699999999999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       430  (0.0239835); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1726.13
//
Query:       EFC35440.1  [L=217]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.5e-06   27.0   0.0    1.4e-05   25.6   0.0    1.7  1  VWA_2     von Willebrand factor type A domain
    0.00051   20.3   0.1     0.0022   18.3   0.1    1.9  1  VWA       von Willebrand factor type A domain
  ------ inclusion threshold ------
       0.13   11.6   0.0       0.23   10.8   0.0    1.4  1  VWA_CoxE  VWA domain containing CoxE-like protein
       0.13   12.2   0.0        5.3    7.0   0.0    2.3  2  RepA_N    Replication initiator protein A (RepA) N-terminus


Domain annotation for each model (and alignments):
>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.0   3.2e-09   1.4e-05       1     106 [.      76     195 ..      76     196 .. 0.80

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 3.2e-09
       VWA_2   1 lvfvlDtSgSmrngdy...............gptrleaakdaveallksl...pgd.rvglvtfsdgpevlipltkdkakilnalrnleakgggtnlaa 80 
                 lv+++D SgSm++ d                + tr++ + +a++ l++s+   ++d +v l+ f+++++ +i   ++  ++ +a ++ ++    tnl  
  EFC35440.1  76 LVLIIDHSGSMGSFDEdatgqnrskglvdsnHWTRYDNVIQAAKYLSESIlqyDKDgKVPLIFFDSNVREVI--VDSIPRLVAAFEKNQPN-SSTNLLG 171
                 79*********9987778899999999998856677777777777777544446556***********8877..4678899999*****95.******* PP

       VWA_2  81 aLqlarkalkkrrkgekrvivlitDg 106
                 aL+la+k   ++  +e+   +++tDg
  EFC35440.1 172 ALELAFKNHVND--HENVLFIVFTDG 195
                 ******965433..568889999998 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.1   4.9e-07    0.0022       2     122 ..      76     205 ..      75     211 .. 0.59

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 4.9e-07
                 EEEEEE-STTSCHHHHH.HHHHHHHHHHHHHT...B.....TTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTG.SGGGGSSC-HHHHHHHHHH CS
         VWA   2 ivfvlDgSgsmgeenfe.kvkefikklvekle...v.....gpegtrvglvqfssevktefslndysskeellsalnnl.kysgggttntgkalkyale 90 
                 +v+++D Sgsmg  + + + ++  k lv++     +       +  + +++q+ ++ k+   + d + +e + +++ +l    ++++ n  ++l  ale
  EFC35440.1  76 LVLIIDHSGSMGSFDEDaTGQNRSKGLVDSNHwtrYdnviqAAKYLSESILQYDKDGKVPLIFFDSNVREVIVDSIPRLvAAFEKNQPNSSTNLLGALE 174
                 799********5555554455555566666654331333433444446667777775555444444445666666666665555555556666666666 PP

                 HHHHHHGTSSTTSEEEEEEEESS--CSS.HTHH CS
         VWA  91 klfkssagaRenakkviilltdGksndg.dpke 122
                  +fk   +  ++ + ++i++tdG +n++  pk 
  EFC35440.1 175 LAFKNHVN--DHENVLFIVFTDGSPNGEsYPKA 205
                 66666666..3445899********99435554 PP

>> VWA_CoxE  VWA domain containing CoxE-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   5.1e-05      0.23      23      73 ..      37      89 ..      19      93 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 5.1e-05
    VWA_CoxE 23 rrgrriDlrrtlranlrhggelvelvrrkp...rerkprelvllvDvSgSmaay 73
                rr+++i  +  + + +r ++e     +++      + + +lvl++D SgSm ++
  EFC35440.1 37 RREMEICRQYEIESKMREMHEAKFHQYSENkepALQ-NLQLVLIIDHSGSMGSF 89
                555555555666777777777555555543111444.45************876 PP

>> RepA_N  Replication initiator protein A (RepA) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.024   1.1e+02      37      62 ..     122     147 ..     113     160 .. 0.79
   2 ?    7.0   0.0    0.0012       5.3      33      54 ..     172     193 ..     167     196 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.024
      RepA_N  37 SiknnwiDeegrvYliftieelaell 62 
                 S +  + D++g+v lif  +++ e++
  EFC35440.1 122 SESILQYDKDGKVPLIFFDSNVREVI 147
                 5556678**********999988876 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0012
      RepA_N  33 RlelSiknnwiDeegrvYlift 54 
                  lel++kn+  D+e+  +++ft
  EFC35440.1 172 ALELAFKNHVNDHENVLFIVFT 193
                 689******************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       907  (0.0505884); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1334.78
//
Query:       EFC35441.1  [L=178]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       360  (0.0200792); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.42u 0.24s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 1340.67
//
Query:       EFC35442.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.2   11.7   3.4       0.63   10.1   0.1    2.6  2  ADK_lid   Adenylate kinase, active site lid


Domain annotation for each model (and alignments):
>> ADK_lid  Adenylate kinase, active site lid
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.1   3.5e-05      0.63      11      29 ..      14      33 ..       9      34 .. 0.78
   2 ?    1.3   0.5     0.019   3.4e+02       3       8 ..      43      48 ..      42      49 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 3.5e-05
                EETTT.B--SSTTB-TTT-- CS
     ADK_lid 11 Yhvvf.npPkveglCDkCGe 29
                Yh v   + +++ +CDkC++
  EFC35442.1 14 YHHVIhLKQRNDSICDKCNV 33
                8766546789********97 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.019
                E-TTT- CS
     ADK_lid  3 vCpkCG 8 
                +CpkC+
  EFC35442.1 43 TCPKCN 48
                79**97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       865  (0.0482459); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1021.92
//
Query:       EFC35443.1  [L=622]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
       0.12   12.1   0.1       0.12   12.1   0.1    2.6  3  Thioredoxin_9  Thioredoxin
       0.18   12.0   2.3        1.1    9.5   0.5    2.6  2  HTH_52         Helix-turn-helix domain


Domain annotation for each model (and alignments):
>> Thioredoxin_9  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.1   1.3e-05      0.12       8      70 ..       8      79 ..       1      96 [. 0.79
   2 ?   -2.9   0.0      0.61   5.4e+03       9      36 ..     188     214 ..     182     219 .. 0.73
   3 ?   -2.5   1.0      0.45   4.1e+03      13      28 ..     503     518 ..     475     544 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.3e-05
                   HHTS-H...HHHHHHHHHHHHHHHH---HH......HHHT--S-EEEEEE--TT-HHHHHHHHHHHHHHHH- CS
  Thioredoxin_9  8 leemtk...enkermlrvykkvelseetee......kiksiekklkilvltedwCgDaavnvPvlakiaeln 70
                    e+m++   ++k+ m+r+ + ++l+e+ +        i  ++  +ki+ +t  +C  ++ n P l+ i+e +
     EFC35443.1  8 KENMEEfmlKRKDIMERLTEPFQLTEKLIVtfelqdYIGDLSHFWKIFQITNSFCAHCMSNYPKLKFIQEKT 79
                   344444444688899999999999998877665555777889999***********************9876 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.61
                    HTS-HHHHHHHHHHHHHHHHH---HHHH CS
  Thioredoxin_9   9 eemtkenkermlrvykkvelseeteeki 36 
                    +e+++   +r +++y+++e  ++  e i
     EFC35443.1 188 KENSD-ISQRRKQIYERFEYGKDNLEWI 214
                    45555.6788899999999888877655 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.45
                    HHHHHHHHHHHHHHHH CS
  Thioredoxin_9  13 kenkermlrvykkvel 28 
                    ++ k++++++  +++ 
     EFC35443.1 503 RKIKDQLNEIAVRLKS 518
                    2344444444444444 PP

>> HTH_52  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1     0.053   4.7e+02       6      35 ..      21      51 ..      19      53 .. 0.75
   2 ?    9.5   0.5   0.00013       1.1      27      57 ..     360     390 ..     357     393 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.053
      HTH_52  6 vlkekeeewsi.qeLmehpeledYsvDLevl 35
                +++   e+++  + L+   el+dY  DL+ +
  EFC35443.1 21 IMERLTEPFQLtEKLIVTFELQDYIGDLSHF 51
                6666666775415699999*********865 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00013
      HTH_52  27 dYsvDLevlleyLveKgiievvkvetKgkgi 57 
                 +Y  +Le +leyL  K++ e vkve  +++i
  EFC35443.1 360 KYLPELEWFLEYLKSKKLDEYVKVERNQQKI 390
                 68889************99999999998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (622 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2796  (0.155948); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.80u 0.36s 00:00:01.16 Elapsed: 00:00:00.52
# Mc/sec: 3599.36
//
Query:       EFC35444.1  [L=246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.8e-17   61.5   8.1     0.0003   21.5   0.3    4.4  4  WD40         WD domain, G-beta repeat
  ------ inclusion threshold ------
      0.024   13.3   0.3        0.2   10.3   0.1    2.3  3  Nup160       Nucleoporin Nup120/160
        5.6    4.9  12.9        6.6    4.7  12.9    1.0  1  DNA_pol_phi  DNA polymerase phi
        7.9    5.7   8.9         14    4.9   8.9    1.5  1  NOA36        NOA36 protein


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.1   0.00019      0.84      19      38 .]      18      37 ..       2      37 .. 0.75
   2 !   19.7   0.4   2.5e-07    0.0011       9      38 .]      49      80 ..      41      80 .. 0.81
   3 !   21.5   0.3   6.6e-08    0.0003       4      38 .]     105     141 ..     102     141 .. 0.86
   4 !   11.9   0.0   7.5e-05      0.34       5      37 ..     152     186 ..     148     187 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00019
                ETTSSEEEEEETTSEEEEEE CS
        WD40 19 spdgawlasGsdDgtvriWd 38
                + +g+ ++s+s D t +iWd
  EFC35444.1 18 PINGDHFMSCSGDMTMKIWD 37
                457888999988*******9 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 2.5e-07
                SSSS.EEEEEEETTSSEEE.EEETTSEEEEEE CS
        WD40  9 GHss.vtslafspdgawla.sGsdDgtvriWd 38
                 H+  v ++++++ +  ++ +Gs D+t+++Wd
  EFC35444.1 49 VHNYeVLACDWNKFNEHIVcTGSVDKTIKVWD 80
                57556999*9999999976489*********9 PP

  == domain 3  score: 21.5 bits;  conditional E-value: 6.6e-08
                 EEEEESS.SSEEEEEEETTSSEEEEE..ETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtslafspdgawlasG..sdDgtvriWd 38 
                 + tltGH + ++ l+fsp+   ++ G  s+D ++ iWd
  EFC35444.1 105 ICTLTGHgFAIRRLKFSPHDENII-GsvSYDMSLCIWD 141
                 5789***777************99.63468*******9 PP

  == domain 4  score: 11.9 bits;  conditional E-value: 7.5e-05
                 EEEESS.SSEEEEEEETTSSE.......EEEEETTSEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgaw.......lasGsdDgtvriW 37 
                  +++ H  +v ++      ++       +as+s+D tv++W
  EFC35444.1 152 EKYEHHsEFVVGI------DFnlemedeIASCSWDETVYVW 186
                 5678885558899......666688999************* PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.11   4.8e+02     230     255 ..      21      46 ..      10      54 .. 0.72
   2 ?   10.3   0.1   4.4e-05       0.2     229     259 ..      63      93 ..      45     112 .. 0.81
   3 ?   -1.0   0.0      0.12   5.2e+02     229     250 ..     124     145 ..      95     150 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.11
                 TTEEEEEETT-EEEEEETTTTEEEEE CS
      Nup160 230 qtylfalsrdgkLrvWnlltgkclat 255
                  ++ ++ s d ++++W++ + + l +
  EFC35444.1  21 GDHFMSCSGDMTMKIWDIHDISSLQS 46 
                 56667788899*****9987666655 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 4.4e-05
                 TTTEEEEEETT-EEEEEETTTTEEEEEEE-- CS
      Nup160 229 gqtylfalsrdgkLrvWnlltgkclatidll 259
                 ++ ++++ s+d++++vW+l+++ + +++ + 
  EFC35444.1  63 NEHIVCTGSVDKTIKVWDLRNLNQHRSGAIM 93 
                 67899****************9998886665 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.12
                 TTTEEEEEETT-EEEEEETTTT CS
      Nup160 229 gqtylfalsrdgkLrvWnlltg 250
                 +++++ ++s d  L +W+++ g
  EFC35444.1 124 DENIIGSVSYDMSLCIWDTEQG 145
                 899999***********99876 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7  12.9    0.0015       6.6     669     718 ..     196     241 ..     144     245 .. 0.62

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0015
  DNA_pol_phi 669 eesdedeededdedvdeidelreklaealgesgededdddsdsDedmdDe 718
                  +e+de+ ed+++ ++    ++r+ l  a g +   ed++ +++Ded+d++
   EFC35444.1 196 HEEDENAEDDEENEIVS--QFRQVLGLARGGGA--EDEEYDEDDEDLDED 241
                  33333333333333333..89999999998888..666666666667776 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   8.9    0.0031        14     240     291 ..     198     245 ..     170     246 .] 0.53

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0031
       NOA36 240 qadgsddddddeedsdydaylkalasgddeddegdedddddddeedddeeed 291
                 ++++++dd+++e  s++ + l+   +g  ed+e dedd+d d    +d+ee+
  EFC35444.1 198 EDENAEDDEENEIVSQFRQVLGLARGGGAEDEEYDEDDEDLD----EDDEEE 245
                 344555555555555555544443333333333333222222....222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       624  (0.0348039); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 1351.65
//
Query:       EFC35445.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-05   25.1   0.2    2.6e-05   24.1   0.2    1.5  1  RWP-RK    RWP-RK domain


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.2   1.4e-09   2.6e-05       1      47 [.      18      68 ..      18      69 .. 0.86

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.4e-09
      RWP-RK  1 nltleelqqyFslplkeAAksLgvskttLKricR....elgIsRWPyRkik 47
                +ltl+el+++ +l+ ++A k Lg s+ +L+ + +    el + RWP  k +
  EFC35445.1 18 QLTLDELKSVLHLSQEQATKVLGTSSFKLRSLFKkhreELSMVRWPTQKAR 68
                58***********************9888776665555999*****99975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       753  (0.041999); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 2295.96
//
Query:       EFC35446.1  [L=449]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-16   59.4   0.7      1e-15   58.0   0.2    2.0  2  DUF1279   Protein of unknown function (DUF1279)


Domain annotation for each model (and alignments):
>> DUF1279  Protein of unknown function (DUF1279)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0      0.49   8.7e+03      30      52 ..     139     161 ..     137     178 .. 0.70
   2 !   58.0   0.2   5.7e-20     1e-15       2      92 .]     346     438 ..     345     438 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.49
     DUF1279  30 Yllvksgvdveelleklklsvkv 52 
                 Y  v++g++ve+++  +    ++
  EFC35446.1 139 YQEVRKGAEVEPFECGIDNLENW 161
                 66688888888887766655444 PP

  == domain 2  score: 58.0 bits;  conditional E-value: 5.7e-20
     DUF1279   2 klKelfkkYGkvalgvylsislidlgicYllvks....gvdveelleklklsvkvsskkvekksksswgefaiAYaihKilipiRlpiTlaitpl 92 
                 k+K+++k+YG++++++y+ i+++ lg+++ll+++     +dv ++l++ +l++ +  + ++  ++++++++ +A++++K + p+R+ +Tlaitp+
  EFC35446.1 346 KIKRFVKQYGALGIVIYFGIYFLVLGTIFLLLQQgvfaTKDVLQWLHSSGLDKLI--DMSDLDKSEMYANAGVAWVLTKFTEPLRMAVTLAITPS 438
                 89********************************555445788888888888444..566777789***************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (449 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       814  (0.0454013); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2911.71
//
Query:       EFC35447.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       661  (0.0368676); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.41u 0.23s 00:00:00.64 Elapsed: 00:00:00.41
# Mc/sec: 1107.73
//
Query:       EFC35448.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       838  (0.0467399); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1593.51
//
Query:       EFC35449.1  [L=218]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    8.4e-10   39.2   0.0    2.5e-09   37.6   0.0    1.8  2  PolyA_pol  Poly A polymerase head domain


Domain annotation for each model (and alignments):
>> PolyA_pol  Poly A polymerase head domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   0.0   1.4e-13   2.5e-09       1     126 []       9     154 ..       9     154 .. 0.80
   2 ?   -2.1   0.0      0.27   4.9e+03      17      45 ..     159     187 ..     156     211 .. 0.62

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 1.4e-13
                 EEEETHHHHHHHTT---C.............EEEEEECS-HHHHHHHHHHHHT-EEEEETTTTCCCCEECCEE...EEECCEE.CEEEEEE---SSHHH CS
   PolyA_pol   1 lylvGGaVRDlllgkepk.............DvDlatdaapeelakllrkkvkeallsgeefqtiavlekkql...levatfR.lekdesdarnpesek 82 
                 +++vGGaVRD++ +  ++             D+D+    +p+ ++  l +k+k  +      ++++v  ++ +   le   +  l++d ++++++  + 
  EFC35449.1   9 IFIVGGAVRDVIREVIVEkktnalqimnnikDIDIGFGCDPQTFHGRLTRKYKSGVPIPGPRGLVQVGSSNGSdlfLEGKAINgLNNDNKSVKAQIAQC 107
                 59********875443322344666777777**********************9888877778888888775557888665551566666677777788 PP

                 ...HHHHHHCTSSBGGGS-EEECTTTCEE-TTS...HHHHHHTTEE- CS
   PolyA_pol  83 stesleeDlkrRDftiNalaynlnkgkvlDlfg...GikdLkskvir 126
                 + ++l+   + RDft N+l y++ ++ ++D +g   Gikd+ sk +r
  EFC35449.1 108 YGTNLRGENICRDFTCNSLWYDPINKCIIDTIGngqGIKDVISKNLR 154
                 999****************************9887899999998876 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.27
                 -CEEEEEECS-HHHHHHHHHHHHT-EEEE CS
   PolyA_pol  17 pkDvDlatdaapeelakllrkkvkealls 45 
                 p D+ + ++++p++l +  +  +k++ + 
  EFC35449.1 159 PRDWEFWVSGNPTKLMRFYKFLLKGYSAD 187
                 56888888888888876655555554433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       468  (0.026103); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 1503.67
//
Query:       EFC35450.1  [L=1069]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.5e-17   61.7   0.0    2.3e-16   59.9   0.0    2.0  1  Lipase_3       Lipase (class 3)
    9.5e-07   28.9   0.0    3.1e-06   27.2   0.0    2.0  1  MMR_HSR1       50S ribosome-binding GTPase
    3.6e-06   27.2   0.1    9.5e-06   25.8   0.1    1.7  1  Roc            Ras of Complex, Roc, domain of DAPkinase
    0.00073   19.2   0.1     0.0021   17.7   0.1    1.7  1  Ras            Ras family
    0.00083   18.4   0.9     0.0069   15.4   0.0    2.3  2  Spore_IV_A     Stage IV sporulation protein A (spore_IV_A)
     0.0013   18.3   1.5      0.019   14.5   1.4    2.5  1  GTP_EFTU       Elongation factor Tu GTP binding domain
     0.0017   17.8   0.0     0.0048   16.3   0.0    1.7  1  ATPase         KaiC
     0.0045   16.9   0.5     0.0085   16.0   0.5    1.4  1  DUF5567        Family of unknown function (DUF5567)
     0.0049   15.7   0.4     0.0092   14.8   0.4    1.4  1  DUF2207        Predicted membrane protein (DUF2207)
      0.005   16.9   0.2      0.025   14.7   0.1    2.2  2  Dynamin_N      Dynamin family
  ------ inclusion threshold ------
      0.018   15.1   0.0      0.071   13.1   0.0    2.1  1  AAA_14         AAA domain
      0.046   13.0   0.0       0.31   10.3   0.0    2.2  2  Hydrolase_4    Serine aminopeptidase, S33
      0.052   14.1   0.0       0.11   13.0   0.0    1.5  1  Abhydrolase_6  Alpha/beta hydrolase family


Domain annotation for each model (and alignments):
>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.9   0.0   1.7e-19   2.3e-16       1     138 [.      89     220 ..      89     223 .. 0.85

  Alignments for each domain:
  == domain 1  score: 59.9 bits;  conditional E-value: 1.7e-19
                 EEEE----------------EEE-HHHH-GTT-EEEHHHHHHHHS-HHHHHHHHHHHHHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS...--- CS
    Lipase_3   1 vvafRGtesakdwltdldfslteakellekeggkvhsgfleayeeslreqvlkelkrllekypeysivvtGHSLGgalAlLaaldlvengene...kkk 96 
                 vva+RG+ s++d+ltd++  +           g +hsgfle +++   + +l+++      ++ y++v+tGHS+Gga+ +++a+ l +  e +   k +
  EFC35450.1  89 VVAIRGSYSKSDILTDVKLIPAMNYY--G--YGVLHSGFLERAKFIPLDYFLEKI------NEGYQVVITGHSMGGAVGAILATRLMQATEAKaikKPP 177
                 79*************99876654444..3..799**********66666666665......44688************9999999999999989999** PP

                 EEEEEES----B-HHHHHHHHT-TTEEEEEE.EETT--GGG-S CS
    Lipase_3  97 vtvvtfGqPrvgnkefaklvdsqlnkkvlrv.vntnDivPrlp 138
                 ++ + fG P   + +f++++ +  +++++++ +n++D vPr  
  EFC35450.1 178 IQFIGFGVPLLADVKFKERILKDEQSNYFHFyINEKDCVPRSI 220
                 ********************988888888853899*****975 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   0.0   2.3e-09   3.1e-06       2     114 .]     794     904 ..     793     904 .. 0.71

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 2.3e-09
                 EEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT....TTCSHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas....eeklkplde 95 
                 v++vG+   GKSt++ + + ++a +s++  tT +i+ + ++ + +++ ++D p  +e  s+++  + +f   +   d i++v da     +   ++ +e
  EFC35450.1 794 VGVVGMKKCGKSTFVEKFLHRNANASSIIATT-EIQAYPLTSNSSNFAVWDFPH-YE--SQDHLHKVQFITSRFlLDYIVVVYDALskcdK---EECKE 885
                 89**********************99998766.677777877789*********.99..33333334444333347********7743322...22233 PP

                 HHHHHHHHTTSEEEEEEES CS
    MMR_HSR1  96 eleelleeakkplilvlnk 114
                 +++ ++++++ ++i+++nk
  EFC35450.1 886 HINVIKQSNDHRFIVLMNK 904
                 3444433367778888887 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.1   6.9e-09   9.5e-06       4     119 ..     796     906 ..     794     907 .. 0.69

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 6.9e-09
                 EESSTTSSHHHHHHCHCT-CCC-EE.ETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HH.HHCTS...CEEEEEEE..GHHH.HC CS
         Roc   4 lvGdsgvGKtsllkrfvedkfseke.kstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhpl.ylrea...alailvyd..srss.en 94 
                 +vG ++ GK++++++f++++ + ++  +t+ ++ +  +             ++ ++++WD+   e  + lh++ +++++   + +++vyd  s+ + e+
  EFC35450.1 796 VVGMKKCGKSTFVEKFLHRNANASSiIATTEIQAYPLT------------SNSSNFAVWDFPHYESQDHLHKVqFITSRfllDYIVVVYDalSKCDkEE 882
                 79***************988875531345554444322............13458***************98725555522234678999654433267 PP

                 HHHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  95 lkeWlkelkkvagkspvilvgnkiD 119
                  ke ++ +k+ + +  +i+++nk+D
  EFC35450.1 883 CKEHINVIKQSN-DHRFIVLMNKAD 906
                 788888887755.566788899998 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.1   1.5e-06    0.0021       4     118 ..     796     909 ..     794     943 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 1.5e-06
                 EEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTE....SEEEEEEETTBHHHHHTHHHHHHHHH CS
         Ras   4 lvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrda....egillvyditsresfenvkkwveeik 98 
                 +vG + +GK++++ +f + + + +++  i +   ++   + +++ ++ +wD    e  ++l++  + ++    + i++vyd  s+   e++k+ ++ ik
  EFC35450.1 796 VVGMKKCGKSTFVEKFLHRNANASSI--I-ATTEIQAYPLTSNSSNFAVWDFPHYESQDHLHKVQFITSrfllDYIVVVYDALSKCDKEECKEHINVIK 891
                 89**************9876555433..3.55689999999***************9999999998887222245778999999999999999888888 PP

                 HHSTTTSEEEEEEETTTGGG CS
         Ras  99 rvaeenvpivLvGnKvDlee 118
                 +  +    ++++ nK+D   
  EFC35450.1 892 QSND--HRFIVLMNKADALY 909
                 8877..58888899*99765 PP

>> Spore_IV_A  Stage IV sporulation protein A (spore_IV_A)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0     5e-06    0.0069       9      39 ..     783     813 ..     776     819 .. 0.86
   2 ?    0.5   0.4      0.16   2.2e+02     194     259 ..     992    1057 ..     955    1066 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 5e-06
  Spore_IV_A   9 diaertngdiyigvvGpvRtGKStfikrfme 39 
                 +i++    ++y+gvvG  ++GKStf+ +f+ 
  EFC35450.1 783 QIRQELMKNFYVGVVGMKKCGKSTFVEKFLH 813
                 5777777899*******************86 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.16
  Spore_IV_A  194 seetkelaeeleekydvkvlavnveelkeedikeilekvLyefpvkeielelpkwvealekdhelk 259 
                  + ++ +++ e+++k + + ++++ ++lk+ + +e++e++  ef+ ++i++++ + +e++++ ++l 
  EFC35450.1  992 KYDALKVSIEFRRKGKNSSFCFSWDKLKNLQFRELVEELKNEFDYDNIKITTKNSLEEISDMQQLL 1057
                  445566666777888888899999999999999999*9999*****99999999999988777664 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   1.4   1.4e-05     0.019      87     150 ..     858     924 ..     790    1036 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.4e-05
                 HHHHHHT-SEEEEEEETTTB.STHHHHHHHHHHHHTTTE.EEEEEESCGST.HHHHHHHHHHHHHHH CS
    GTP_EFTU  87 virglrvlDgavlvvdaveG.vepqteevlrlalkegvp.iivfiNKmDrl.kaelkeiveevkqkl 150
                  i++   lD+ v+v da +   ++  +e+++++++ + + +iv++NK+D l k +++++++   ++ 
  EFC35450.1 858 FITSRFLLDYIVVVYDALSKcDKEECKEHINVIKQSNDHrFIVLMNKADALyKPNMNMTKDHFDDTR 924
                 5788899**********877256789*******9998777***********8666666666655433 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   3.5e-06    0.0048      18      92 ..     790     862 ..     781     900 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.5e-06
      ATPase  18 egrvvlitGepGtGKtifalqFlikgaekygepgvfvtveepaedlrenakslG.wdlekleeegklaiidasesa 92 
                 ++  v ++G   +GK++f+++Fl + a+      ++ t+e +a  l  n +++  wd+ ++e++++l  ++  +s+
  EFC35450.1 790 KNFYVGVVGMKKCGKSTFVEKFLHRNANA---SSIIATTEIQAYPLTSNSSNFAvWDFPHYESQDHLHKVQFITSR 862
                 55568899******************777...9*****************999669*********99988877765 PP

>> DUF5567  Family of unknown function (DUF5567)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.5   6.1e-06    0.0085     201     232 ..    1030    1061 ..    1024    1063 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 6.1e-06
     DUF5567  201 LdEeFDYDnVaLtpKfseaEletlkelskrkr 232 
                  L  eFDYDn+ +t K s  E++ +++l +++ 
  EFC35450.1 1030 LKNEFDYDNIKITTKNSLEEISDMQQLLEHED 1061
                  789***********************999875 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.4   6.7e-06    0.0092     310     474 ..     559     727 ..     511     729 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 6.7e-06
     DUF2207 310 kndeeldpyEkalldlLfdkseeg.ks...lkeikkyakkskkkakkfkkalkkwksavkk..........kergyfdkkgkkklkklsalglgliilg 394
                  n +   +   +ll+++f++ +e+  +   l +++  +++   +  k++++   +++ v+k          ++  +++++ ++k+     ++ ++i +g
  EFC35450.1 559 SNID-SQELNMKLLRMFFEGTNEQvGDygkLFHLNFSFST---ETAKLSEESLTFRDLVDKkfltvlhhnsVQCSLIKEMFSEKIGMGASAAGLGISAG 653
                 3333.37888899*****7776665447775566666666...89999999999999999999999999985555666665555555555555555555 PP

     DUF2207 395 lilillallllvlllvfllilllillliaiivlllfsrllgrrteeGaellakwkgFkkyLeDfsefkerppedlelwer 474
                 ++ +ll++ +    +++++i +li   +  + l+ f++++  + ++ +++l++ +++k ++  f     +++++l ++e+
  EFC35450.1 654 VCSGLLFVPG----INLFAIGALIATGV--VSLASFAAFMANYVRKNRDVLDYEQNLKTFMDSFYIVYSHSIPTLYHFEK 727
                 5555555433....33333333333333..3333444578899999**************99887776666666666666 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.1   1.8e-05     0.025       1      33 [.     794     826 ..     794     829 .. 0.92
   2 ?   -2.4   0.0       3.2   4.4e+03     130     167 ..     866     904 ..     826     905 .. 0.60

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.8e-05
                 EEEEEBTTTTHHHHHHHHHTS--S---SSS--- CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlgedilprgpnptTr 33 
                 + vvG+ + GKS+++++ l+++ + ++ + tT 
  EFC35450.1 794 VGVVGMKKCGKSTFVEKFLHRNANASSIIATTE 826
                 78********************99999988885 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3.2
                 EEEEEEEETTS-CCC-C.HHHHHHHHSTTBTTEEEEEE- CS
   Dynamin_N 130 diilavtsanhdlsnse.alflarevdpkgkrtivvltk 167
                 d i++v +a +++ + e ++ ++   +++++r+iv+++k
  EFC35450.1 866 DYIVVVYDALSKCDKEEcKEHINVIKQSNDHRFIVLMNK 904
                 566777777776666641444444455666668888777 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   5.2e-05     0.071       5      35 ..     794     823 ..     790     899 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 5.2e-05
      AAA_14   5 lvitGaRrvGKTtllkqlikellvkkesily 35 
                 + ++G++++GK+t+++++++++  +++si+ 
  EFC35450.1 794 VGVVGMKKCGKSTFVEKFLHRNA-NASSIIA 823
                 789****************9888.5555554 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   0.00022      0.31      71      96 ..     138     163 ..     132     178 .. 0.76
   2 ?   -1.0   0.0      0.61   8.4e+02     116     158 ..     266     309 ..     252     336 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00022
  Hydrolase_4  71 eehpelplfllGhSmGGliallyllr 96 
                  + +++ ++++ GhSmGG++ + +++r
   EFC35450.1 138 KINEGYQVVITGHSMGGAVGAILATR 163
                  4457889***********99887754 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.61
  Hydrolase_4 116 klk.appllklllkllgkllpklqvsnnlkadslsrdpevvaay 158
                   ++ ++++ k+++k++ k +p++++ +n+   s s++++ v ++
   EFC35450.1 266 GISvFQWFSKVIAKVIHKYAPQFSPFGNHIHISYSNNKQIVTEH 309
                  445588999999*********99994444444444444444333 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   8.3e-05      0.11      56      86 ..     135     161 ..     110     219 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 8.3e-05
                    HHCCTT..TTSEEEEEETCHHHHHHHHHHCC CS
  Abhydrolase_6  56 lldelaagggpvvlvGHSlGGalalaaapla 86 
                    +l+++   g +vv+ GHS+GGa+++    la
     EFC35450.1 135 FLEKIN-EGYQVVITGHSMGGAVGAI---LA 161
                    555554.78899**********9999...55 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1069 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1288  (0.0718389); expected 358.6 (0.02)
Passed bias filter:                      642  (0.0358079); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.91u 0.34s 00:00:01.25 Elapsed: 00:00:00.55
# Mc/sec: 5884.44
//
Query:       EFC35451.1  [L=262]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (262 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1593.95
//
Query:       EFC35452.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.6e-43  148.3   0.4    4.9e-43  147.4   0.4    1.4  1  Pkinase         Protein kinase domain
    5.2e-40  137.4   0.1    2.1e-38  132.1   0.1    2.0  1  Pkinase_Tyr     Protein tyrosine kinase
    1.5e-06   27.2   0.1    2.2e-06   26.7   0.1    1.2  1  Pkinase_fungal  Fungal protein kinase
     0.0055   16.6   0.0     0.0097   15.8   0.0    1.4  1  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.021   13.8   0.0      0.031   13.2   0.0    1.3  1  Haspin_kinase   Haspin like kinase domain
      0.051   12.9   0.0      0.064   12.6   0.0    1.2  1  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  147.4   0.4   1.7e-46   4.9e-43      52     259 ..       1     247 [.       1     250 [. 0.83

  Alignments for each domain:
  == domain 1  score: 147.4 bits;  conditional E-value: 1.7e-46
                 HHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS--HHHHH.HHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SG CS
     Pkinase  52 lkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgslseeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDF 142
                 + +l+hp iv +++v  +++  y+++ey+e+g+l++++      + ++   e+k ki++ +++gl ylHs +   iiHrDlKp N+L+d++ + K++DF
  EFC35452.1   1 MSSLRHPCIVSCFGVSLTTNGKYMIVEYLENGSLEKAIYnskmGR-TILRFETKlKILTDVAKGLVYLHSIKphrIIHRDLKPGNLLLDKNMNAKVGDF 98 
                 57899*******************************998654322.3445555559*************865566**************999******* PP

                 TTSEESSSSCS.BCTTTSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT..........SHH...H CS
     Pkinase 143 Glakelesssk.ltsfvgtseYlAPEvl..keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..........etkeklp 228
                 Gl+k ++++s  +t  vgt  Y+APE+l  ++++ s+kvD++s G+i++e+l+++ pfs         +e+d ++++++il+                 
  EFC35452.1  99 GLSKIVSNNSAtMTANVGTLLYMAPELLsnDHKGQSTKVDIYSFGIIMWEILFEESPFS---------NEIDGFTNVFQILKkvtkghrpplL------ 182
                 *******9998899**************7666888************************.........2455555555555522112223330...... PP

                 HHTTS......................................-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 229 easei......................................seeakdllkkllkkdpkkRltaeell 259
                     +                                       e+ +++++++++ d +kR+ + e+ 
  EFC35452.1 183 ----FetsallegdknqkvdewidhnftkkqietigkenisklYESYIEIMEQCWNHDASKRPEFIEIT 247
                 ....144455666666678888899****************9999******************987775 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  132.1   0.1     7e-42   2.1e-38      55     259 .]       1     250 [.       1     250 [. 0.87

  Alignments for each domain:
  == domain 1  score: 132.1 bits;  conditional E-value: 7e-42
                  HHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CTTTSBHHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETTEEEE-ST CS
  Pkinase_Tyr  55 mkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ekekltlkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDf 147
                  m++l+hp iv++ gv + ++  ++++ey+++G+L+k + ++   ++ l+++++l++ ++vAkG+ yL+s k   ++Hrdl   N Ll++n+ +k++Df
   EFC35452.1   1 MSSLRHPCIVSCFGVSLTTNGKYMIVEYLENGSLEKAIYNSkmGRTILRFETKLKILTDVAKGLVYLHSIKphrIIHRDLKPGNLLLDKNMNAKVGDF 98 
                  899**************99999**************99988445677999******************976555************************ PP

                  TTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..EEHHHHHHHHHHHHHHHHTTSSGT...................................... CS
  Pkinase_Tyr 148 GLardiekddeyvkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwEiftlgesp...................................... 205
                  GL++ +  +++  + + +   + +mapE l++ +   ++k D++sfG+++wEi+   esp                                      
   EFC35452.1  99 GLSKIV--SNNSATMTANVGTLLYMAPELLSNDHkgQSTKVDIYSFGIIMWEILF-EESPfsneidgftnvfqilkkvtkghrppllfetsallegdk 193
                  ****99..444455666778899*******9988779****************98.688899*******************************88877 PP

                  ...TTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 206 ...ypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                     + ++ ++++++k  e    e+ +k  e+  e+m++cw++d+++Rp+f e++++l
   EFC35452.1 194 nqkVDEWIDHNFTKKQIETIGKENISKLYESYIEIMEQCWNHDASKRPEFIEITDQL 250
                  7666666666666665555556666677888889******************99876 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.1   7.5e-10   2.2e-06     291     400 ..      39     142 ..      31     150 .. 0.78

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 7.5e-10
  Pkinase_fungal 291 vispvGkpiekaespkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaiev 385
                       s +G++i ++e+++++l+ ++  +  + s     +i+HrD   +N+l+      ++ +  + D+ l k +s+  +++     +GTl +ma e+
      EFC35452.1  39 YNSKMGRTILRFETKLKILTDVAKGLVYLHSIK-PHRIIHRDLKPGNLLLD-----KNMNAKVGDFGLSKIVSN--NSATMTANVGTLLYMAPEL 125
                     56889*********9888776666666666665.789*************9.....66788899*********6..4445578************ PP

  Pkinase_fungal 386 lkgee...HsyrhDLESf 400
                     l+ ++    s   D+ Sf
      EFC35452.1 126 LS-NDhkgQSTKVDIYSF 142
                     **.450233445566655 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   3.2e-06    0.0097     164     183 ..      71      90 ..      44     103 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 3.2e-06
                 S-EEEE-SS-SGGGEEEC.. CS
         APH 164 lptvllHgDlhpgNllvdpd 183
                  p++++H+Dl+pgNll+d++
  EFC35452.1  71 KPHRIIHRDLKPGNLLLDKN 90 
                 6899**************44 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   1.1e-05     0.031     226     263 ..      73     110 ..      21     120 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.1e-05
  Haspin_kinase 226 feFEHRdLhldniLvdknlnvtlidlklsRlessegkv 263
                     +  HRdL+ +n L+dkn+n  + d+ ls++ s+++ +
     EFC35452.1  73 HRIIHRDLKPGNLLLDKNMNAKVGDFGLSKIVSNNSAT 110
                    5667**************************98666655 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   2.2e-05     0.064     161     262 ..      71     169 ..      32     195 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.2e-05
  Kinase-like 161 qakglvhgkftvdnllldekgglmlggft..aLvragtkvvlseve.kgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwclklPltlate 255
                  + + ++h ++++ nllld++   ++g+f+  ++v        ++v    +  pEll++      ++k ++  k+d +  G+ ++ i   + P+ +  +
   EFC35452.1  71 KPHRIIHRDLKPGNLLLDKNMNAKVGDFGlsKIVSNNSATMTANVGtLLYMAPELLSN------DHKGQS-TKVDIYSFGIIMWEILFEESPFSNEID 161
                  45689*********************99622555555555544554467999****99......455555.589************999999999999 PP

  Kinase-like 256 eakeew.k 262
                  ++ + + +
   EFC35452.1 162 GFTNVFqI 169
                  98887633 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       765  (0.0426683); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1590.12
//
Query:       EFC35453.1  [L=309]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-13   51.0   0.0    2.9e-13   50.0   0.0    1.5  1  VWA_3            von Willebrand factor type A domain
  ------ inclusion threshold ------
      0.025   14.4   0.3      0.059   13.2   0.3    1.6  1  Peptidase_C25_C  Peptidase family C25, C terminal ig-like dom


Domain annotation for each model (and alignments):
>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.0   0.0   3.3e-17   2.9e-13       2      78 ..     227     307 ..     226     309 .] 0.94

  Alignments for each domain:
  == domain 1  score: 50.0 bits;  conditional E-value: 3.3e-17
       VWA_3   2 evvivvDvsssmsaen.klvkdaLsvalrq..Lptnd.kiavllfgtkprplfpgsravsaaelqealqkikelels.lgas 78 
                 ++vi+ D+s sm++++ k+++d++++++++  + t+d ki+++l+g++++ +f++ +++++++l++++q+++ ++++ lg++
  EFC35453.1 227 QIVILGDASGSMKGSPfKTLIDCFNNFVQSkaFITGDlKISIALWGSTTE-WFKHRDTIEPTDLDALNQFLNVWSVPlLGNT 307
                 8****************************999999999**********66.************************9966665 PP

>> Peptidase_C25_C  Peptidase family C25, C terminal ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.3   6.5e-06     0.059       5      51 ..     188     230 ..     185     233 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 6.5e-06
                      -EE--SEEETT-SEEEEEESSTT-EEEEEETTEEEEEEE-BTTEEEE CS
  Peptidase_C25_C   5 tvtaPasiplgtnsievscdvdgalvalSannkllGsaivasGqatl 51 
                      ++  Pa+++  +  +++++     l + S+n kl Gs i ++Gq ++
       EFC35453.1 188 KIIEPAQVTTRADALKINTS----LKTTSKNSKLAGSSIIEEGQIVI 230
                      67889999999999999876....99******************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       784  (0.043728); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1805.13
//
Query:       EFC35454.1  [L=346]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.046   14.0   0.0       0.15   12.4   0.0    1.9  1  LAGLIDADG_3     LAGLIDADG-like domain
        1.8    8.9   8.7       0.17   12.2   1.5    2.6  2  Cytomega_UL20A  Cytomegalovirus UL20A protein


Domain annotation for each model (and alignments):
>> LAGLIDADG_3  LAGLIDADG-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.7e-05      0.15      13      76 ..     278     333 ..     277     340 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.7e-05
                  HCCECCECSTTTTSEEEEES-HHHHHHHHHHHHHCT.HSCEEEEEEE-SCCCCECCCHCHCTTC CS
  LAGLIDADG_3  13 aDGsvskskkkgvsisltssskelledvqrlLlrlGIestiyekkkakgrgvyrlliisgenlk 76 
                  +DG v  +  +++ ++ +ss++ ll+ vq l++r+  es i+++     r+++rl  i ++ l+
   EFC35454.1 278 SDGDVISFVSTKT-LRHYSSNEALLNRVQVLMARF--ESVIHNS-----RNYPRLQEIQSKGLQ 333
                  6899988886544.*********************..8888887.....666666666665555 PP

>> Cytomega_UL20A  Cytomegalovirus UL20A protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   1.5   1.9e-05      0.17      16      48 ..      14      46 ..      11      69 .. 0.91
   2 ?   -0.0   0.8      0.12   1.1e+03      26      48 ..     159     181 ..     130     211 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.9e-05
  Cytomega_UL20A 16 tvalaapsqkskrsvtveqpststnsdgnttps 48
                    t  l++ps  s + v v  psts  sdg + ps
      EFC35454.1 14 TKDLSSPSAGSEQRVIVLTPSTSNSSDGSAMPS 46
                    567999************************998 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.12
  Cytomega_UL20A  26 skrsvtveqpststnsdgnttps 48 
                      ++ v+v + stst   g    +
      EFC35454.1 159 IRQRVSVSKSSTSTYKSGYILVT 181
                     34567888888888777765544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1005  (0.0560544); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 1933.70
//
Query:       EFC35455.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.6e-14   52.6   0.9    0.00056   19.7   0.0    3.8  4  LRR_6       Leucine Rich repeat
    3.4e-07   30.5   2.0      0.049   14.1   0.0    3.5  5  LRR_4       Leucine Rich repeats (2 copies)
    0.00023   20.9   2.5      0.005   16.6   0.1    2.9  3  LRR_8       Leucine rich repeat
     0.0076   16.1   0.1      0.014   15.3   0.1    1.5  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.059   13.4   1.6         13    5.9   0.0    3.7  3  ApoB100_C   Apolipoprotein B100 C terminal
       0.27   11.9   0.9         31    5.7   0.0    3.5  3  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       3.8   1.1e+04       8      13 ..      59      64 ..      59      65 .. 0.80
   2 !   19.7   0.0   1.9e-07   0.00056       5      22 ..     151     168 ..     148     169 .. 0.91
   3 !   14.7   0.0   7.6e-06     0.023       5      22 ..     175     192 ..     172     193 .. 0.91
   4 !   14.4   0.0     1e-05      0.03       5      23 ..     199     217 ..     196     218 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.8
       LRR_6  8 LdLsgN 13
                L Ls+N
  EFC35455.1 59 LILSHN 64
                679**9 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 1.9e-07
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+ gN+Ig eGa+ 
  EFC35455.1 151 LTSLDIGGNQIGAEGAKF 168
                 9***************85 PP

  == domain 3  score: 14.7 bits;  conditional E-value: 7.6e-06
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+L++  N+IgDeG++ 
  EFC35455.1 175 LTALNIYLNGIGDEGVKF 192
                 9***************85 PP

  == domain 4  score: 14.4 bits;  conditional E-value: 1e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++L++ gN+Ig eG++ +
  EFC35455.1 199 LKSLNIIGNQIGAEGVKFI 217
                 9***************977 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       4.1   1.2e+04       6      12 ..      59      65 ..      58      68 .. 0.79
   2 !    9.0   0.0   0.00064       1.9      20      36 ..     146     161 ..     141     170 .. 0.79
   3 !   14.1   0.0   1.6e-05     0.049       1      32 [.     149     181 ..     149     188 .. 0.80
   4 !   12.7   0.1   4.5e-05      0.13       2      36 ..     174     209 ..     173     215 .. 0.85
   5 !   12.5   0.5     5e-05      0.15       1      39 [.     197     236 ..     197     237 .] 0.81

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.1
                EE--SS- CS
       LRR_4  6 LdLsnNq 12
                L Ls+N+
  EFC35455.1 59 LILSHNR 65
                7789885 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00064
                 HH-TT--EEE-.-S--- CS
       LRR_4  20 eklpnLkeLdLsgNnli 36 
                 + +++L++Ld+ gN +i
  EFC35455.1 146 NEMKQLTSLDIGGN-QI 161
                 45999999999777.77 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 1.6e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsg 32 
                 ++L++Ld+++Nq+   +  + + +++L+ L++  
  EFC35455.1 149 KQLTSLDIGGNQIGAEGAkFINeMKQLTALNI-Y 181
                 58************877796666********9.4 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 4.5e-05
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 +L+ L++  N + d +    +  +++Lk+L++ gN +i
  EFC35455.1 174 QLTALNIYLNGIGDEGVkfiI-EMKQLKSLNIIGN-QI 209
                 79999999889***9999744.5*********999.76 PP

  == domain 5  score: 12.5 bits;  conditional E-value: 5e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdl 39 
                 ++L++L++ +Nq+   +  + + +++L++L + +N + +++
  EFC35455.1 197 KQLKSLNIIGNQIGAEGVkFISeMKQLTSLVI-NNQQMKSI 236
                 589***********766686655*******99.77676666 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.2   3.7e+03      30      35 ..      59      64 ..      57      70 .. 0.59
   2 !   16.6   0.1   1.7e-06     0.005       2      61 .]     150     209 ..     149     209 .. 0.97
   3 !    8.4   0.3    0.0006       1.8       2      41 ..     198     237 .]     197     237 .] 0.92

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.2
                EE--SS CS
       LRR_8 30 LdLsnN 35
                L Ls+N
  EFC35455.1 59 LILSHN 64
                334444 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 1.7e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+  N++ + + ++ + +++L+ L++  N +     + +  +++L+sL++ gN++
  EFC35455.1 150 QLTSLDIGGNQIGAEGAKFINEMKQLTALNIYLNGIGDEGVKFIIEMKQLKSLNIIGNQI 209
                 7*************************************9999****************97 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0006
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGG CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttls 41 
                 +L+sL++  N++ + + ++ + +++L++L ++n ++++++
  EFC35455.1 198 QLKSLNIIGNQIGAEGVKFISEMKQLTSLVINNQQMKSIN 237
                 799****************************999999885 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.1   4.6e-06     0.014      19      42 ..     104     127 ..      66     130 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 4.6e-06
  F-box-like  19 sdLlrlalVCrrWrrvaldtplLW 42 
                 ++Ll+l lV ++W+++++ + +L+
  EFC35455.1 104 EELLSLILVNKQWYELVSAHHQLY 127
                 46***************9999999 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.1     0.039   1.2e+02      17      32 ..     141     156 ..     125     161 .. 0.79
   2 ?    1.5   0.0     0.099     3e+02      19      32 ..     167     180 ..     158     181 .. 0.82
   3 ?    5.9   0.0    0.0042        13      19      35 ..     215     231 ..     198     233 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.039
   ApoB100_C  17 yEkliaeskrLiDLsI 32 
                 + k+i+e k+L  L I
  EFC35455.1 141 QAKFINEMKQLTSLDI 156
                 569********98877 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.099
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  L I
  EFC35455.1 167 KFINEMKQLTALNI 180
                 9********98877 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0042
   ApoB100_C  19 kliaeskrLiDLsIekY 35 
                 k+i+e k+L  L+I++ 
  EFC35455.1 215 KFISEMKQLTSLVINNQ 231
                 9*************985 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       5.2   1.5e+04       6      12 ..      60      66 ..      59      74 .. 0.68
   2 ?    5.7   0.0      0.01        31       1      12 [.     150     161 ..     150     189 .. 0.84
   3 ?    2.9   0.1     0.081   2.4e+02       1      12 [.     198     209 ..     198     233 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 5.2
       LRR_1  6 dLsnnpl 12
                 Ls+n+ 
  EFC35455.1 60 ILSHNRR 66
                5899984 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+++n++
  EFC35455.1 150 QLTSLDIGGNQI 161
                 599*******98 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.081
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++ +n++
  EFC35455.1 198 QLKSLNIIGNQI 209
                 59****988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1513  (0.0843884); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 1476.36
//
Query:       EFC35456.1  [L=179]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.8e-32  111.7   0.2    4.1e-32  111.6   0.2    1.0  1  Peptidase_M24  Metallopeptidase family M24


Domain annotation for each model (and alignments):
>> Peptidase_M24  Metallopeptidase family M24
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.6   0.2   2.3e-36   4.1e-32      29     188 ..       5     175 ..       1     179 [] 0.85

  Alignments for each domain:
  == domain 1  score: 111.6 bits;  conditional E-value: 2.3e-36
                    HHHHHHHHHHH....HHTTTCEESSSSEEEEGGGGGSTTTBC...SSSB--TTEEEEEEEEEEETTEEEEEEEEEECSSGSHHHHHHHHHHHHHHH CS
  Peptidase_M24  29 elaaeieattl....krhgarglafppivasgenaavlhytp...ndrvlkegdlvlidagaeydgyasDitrTvlvGkftpeqrelyeavleaqe 117
                    ++a++ ea+++    +++ + glafp   ++++n+ ++hy+p   +++v+ ++d++++d+g +++g ++D+++T++    +++++ l++av+ea++
     EFC35456.1   5 DAAEMYEAKARelleADKKKSGLAFP--LGCSINHVAAHYSPnggDETVIGKDDVIKFDLGTHVNGTIIDSAFTMCW---NDQYQPLLDAVKEATN 95 
                    56666665433222233449999***..**************7777888**************************99...778999********** PP

                    HHHHC-STTSBHHHHHHHHHHHHHHTTB........CCGBSSCSEEEESS.SSSEE..EEEESSSTTCSSB--TTBEEEEEE CS
  Peptidase_M24 118 aaikavkpGvtlseidaaarevlesagl........akffphglGHgvGl.evhde..gpsvsresndgrkleeGmvftiEp 188
                    ++++ +  +v+l++++aa++ev+es+++        +k + +++GH++ + +vh    +p+v+  s d++k+ee++ f+iE+
     EFC35456.1  96 MGVRTAGIDVRLGDVGAAIQEVMESYEVtingkthrVKSIENLCGHSIERyRVHSTksVPIVA--SPDNTKMEENEFFAIET 175
                    *************************866777778888999*********99***664467777..568*************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       451  (0.0251548); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1007.59
//
Query:       EFC35457.1  [L=228]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-17   63.3  85.5    0.00013   22.2   7.8    6.4  6  EGF_2     EGF-like domain
     0.0047   17.2   1.8     0.0047   17.2   1.8    7.3  8  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   7.8   2.9e-05      0.26       5      32 .]       5      33 ..       1      33 [. 0.73
   2 !   14.1   7.4   5.1e-06     0.046       6      32 .]      47      72 ..      43      72 .. 0.87
   3 !   15.1   8.5   2.5e-06     0.022       6      32 .]      86     112 ..      77     112 .. 0.86
   4 !   22.2   7.8   1.5e-08   0.00013       6      32 .]     126     151 ..     121     151 .. 0.92
   5 !   11.3  10.4   3.7e-05      0.34       4      32 .]     162     190 ..     156     190 .. 0.84
   6 !   20.6   3.8   4.8e-08   0.00043       6      30 ..     204     227 ..     199     228 .] 0.89

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.9e-05
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyq..GktC 32
                 + C+g GtCv ++ +C+C ++ +  G +C
  EFC35457.1  5 TSVCSGIGTCVYAN-NCSCWNSTFwgGQNC 33
                678********777.8***55544447777 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 5.1e-06
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                + C+g+G C +  G+C C   y G +C
  EFC35457.1 47 SVCSGNGNCLA-PGVCNCTEMYGGSNC 72
                57*******84.56***********99 PP

  == domain 3  score: 15.1 bits;  conditional E-value: 2.5e-06
       EGF_2   6 eiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 e C+   G Cv+++ +C+C+ gy+G +C
  EFC35457.1  86 EVCSYsKGRCVSPN-NCSCSEGYHGSNC 112
                 5677779****999.8************ PP

  == domain 4  score: 22.2 bits;  conditional E-value: 1.5e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g G+C +++ +C C++g++G +C
  EFC35457.1 126 NVCSGKGVCLSLN-NCTCQQGFYGEKC 151
                 68*******9899.8************ PP

  == domain 5  score: 11.3 bits;  conditional E-value: 3.7e-05
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ hG C n    C C   y+G +C
  EFC35457.1 162 DkKDVCSSHGNCSNID-TCNCTKPYYGTNC 190
                 36789*******8555.8************ PP

  == domain 6  score: 20.6 bits;  conditional E-value: 4.8e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 + C+ +G C ++  +C C+ gy+Gk
  EFC35457.1 204 SVCSSRGFCSSLD-NCTCQEGYYGK 227
                 68********999.8*********8 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   2.6     0.037   3.3e+02       5      15 ..       5      17 ..       2      23 .. 0.72
   2 ?   -3.2   0.4       1.3   1.1e+04       1       8 [.      33      40 ..      33      41 .. 0.77
   3 !    4.6   4.2    0.0046        41       5      30 ..      46      69 ..      43      71 .. 0.83
   4 ?   -4.4   1.6         2   1.8e+04       1       8 [.      72      79 ..      72      79 .. 0.64
   5 !   11.1   1.5   4.3e-05      0.38      10      32 .]      93     111 ..      90     111 .. 0.88
   6 !   11.9   3.4   2.3e-05      0.21       4      31 ..     125     149 ..     122     150 .. 0.87
   7 !    5.6   6.5    0.0022        19       5      31 ..     164     188 ..     156     189 .. 0.82
   8 !   17.2   1.8   5.2e-07    0.0047       6      31 ..     206     227 ..     199     228 .] 0.87

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.037
                T..STTT-EEEEE CS
         EGF  5 p..CsngGtCvdt 15
                +  Cs+ GtCv+ 
  EFC35457.1  5 TsvCSGIGTCVYA 17
                355*******975 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.3
                GCSTTSTT CS
         EGF  1 CspnpCsn 8 
                C+ ++C n
  EFC35457.1 33 CDIHKCGN 40
                88888865 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.0046
                T..STTT-EEEEETTTEEEEEECTTEES CS
         EGF  5 p..CsngGtCvdtgrggytCiCpeGytG 30
                p  Cs++G C+ +g     C C+e y G
  EFC35457.1 46 PsvCSGNGNCLAPG----VCNCTEMYGG 69
                566*******9999....****987666 PP

  == domain 4  score: -4.4 bits;  conditional E-value: 2
                GCSTT.STT CS
         EGF  1 Cspnp.Csn 8 
                C+  p Csn
  EFC35457.1 72 CN-VPkCSN 79
                65.367987 PP

  == domain 5  score: 11.1 bits;  conditional E-value: 4.3e-05
                 -EEEEETTTEEEEEECTTEESTT CS
         EGF  10 GtCvdtgrggytCiCpeGytGkr 32 
                 G+Cv++     +C C+eGy+G++
  EFC35457.1  93 GRCVSPN----NCSCSEGYHGSN 111
                 7798888....9*********86 PP

  == domain 6  score: 11.9 bits;  conditional E-value: 2.3e-05
                 TT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytGk 31 
                  + Cs+ G C+++     +C+C++G+ G+
  EFC35457.1 125 LNvCSGKGVCLSLN----NCTCQQGFYGE 149
                 445*******9999....*********98 PP

  == domain 7  score: 5.6 bits;  conditional E-value: 0.0022
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +  Cs +G C +      tC C+ +y G 
  EFC35457.1 164 KdvCSSHGNCSNID----TCNCTKPYYGT 188
                 156*******9999....********995 PP

  == domain 8  score: 17.2 bits;  conditional E-value: 5.2e-07
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G+C ++     +C+C+eGy Gk
  EFC35457.1 206 CSSRGFCSSLD----NCTCQEGYYGK 227
                 *******5555....**********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       647  (0.0360868); expected 358.6 (0.02)
Passed bias filter:                      129  (0.00719505); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.35s 00:00:00.97 Elapsed: 00:00:00.55
# Mc/sec: 1250.77
//
Query:       EFC35458.1  [L=523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0014   18.7   2.6     0.0014   18.7   2.6    2.3  2  I-EGF_1   Integrin beta epidermal growth factor like domain 1
  ------ inclusion threshold ------
      0.026   14.4   0.8       0.07   13.0   0.8    1.7  1  TMEM154   TMEM154 protein family
      0.042   13.6   0.0      0.067   12.9   0.0    1.2  1  Yip1      Yip1 domain
      0.076   13.2   0.2       0.27   11.5   0.2    1.9  1  Rota_NS6  Rotavirus non-structural protein 6
        1.7    9.1  11.4       0.32   11.4   6.8    2.1  2  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> I-EGF_1  Integrin beta epidermal growth factor like domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   2.6   3.9e-07    0.0014      11      29 .]     135     153 ..     132     153 .. 0.95
   2 ?   -3.2   0.6       2.7   9.8e+03      22      26 ..     425     429 ..     425     430 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 3.9e-07
     I-EGF_1  11 kCsgnGtleCGvCrCnpGy 29 
                  C+gnG +  G+C+Cn+G+
  EFC35458.1 135 LCNGNGQFKDGKCVCNSGF 153
                 6****************97 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.7
     I-EGF_1  22 vCrCn 26 
                 +C+C 
  EFC35458.1 425 TCECS 429
                 59996 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.8   1.9e-05      0.07      20      93 ..     416     503 ..     395     519 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.9e-05
     TMEM154  20 esadatsaasteseslkqeeakeslssaelsnesdqlel.................vlmiiiPlvllillllvviiliqkkkrkrsKddek 93 
                  s++   +a  e +sl+ ++++ + +s+e++ +s++ +                  +l+++iPl +l++ +++  +   +kk  + K++++
  EFC35458.1 416 ISIKNNQIATCECSSLRYNLSILEYKSIETASTSSSSNSniivkkpatsnplmwllMLLVLIPLTALLIAVIIWFV---VKKLGKDKNNTR 503
                 4455555666667777766666666677766666655555578888888899999899999999877654444333...445555555543 PP

>> Yip1  Yip1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   1.9e-05     0.067      55     100 ..     459     511 ..     436     516 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.9e-05
        Yip1  55 qgltlssllgaiiggylglllgllllalllhliakllg.......gkgsfkqt 100
                  + ++s +l+++++++++++l++ll+a+++++++k lg       +++s++qt
  EFC35458.1 459 KKPATSNPLMWLLMLLVLIPLTALLIAVIIWFVVKKLGkdknntrNSHSYMQT 511
                 5667889999**************************99777776666667776 PP

>> Rota_NS6  Rotavirus non-structural protein 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.2   7.6e-05      0.27       9      69 ..     196     254 ..     191     262 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 7.6e-05
    Rota_NS6   9 lflenllvgvnstfhqmqkhsintccrslqrildhlillqtihspvfrldrmqlrqmqtla 69 
                  ++ nll g+ns  ++ + hs +t+  sl  + d l  +q+  s  f l r +l ++q + 
  EFC35458.1 196 NYITNLLFGLNSISQNSEYHSNQTANSSLFLLRDALASVQS--STAFVLSRGDLVNLQNIM 254
                 5789*******************************999986..677888888887777665 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   6.8     9e-05      0.32       6      32 .]     134     158 ..     130     158 .. 0.90
   2 ?   -1.5   0.1      0.96   3.4e+03      20      25 ..     425     430 ..     419     433 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 9e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G+     G+C+C+sg++  +C
  EFC35458.1 134 DLCNGNGQFK--DGKCVCNSGFTTSNC 158
                 57*******9..9*********98888 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.96
       EGF_2  20 qCdCds 25 
                  C+C+s
  EFC35458.1 425 TCECSS 430
                 599976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1302  (0.0726198); expected 358.6 (0.02)
Passed bias filter:                      619  (0.0345251); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.73u 0.35s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 2932.93
//
Query:       EFC35459.1  [L=131]
Description: hypothetical protein NAEGRDRAFT_60091 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-15   57.4   0.1    3.2e-15   56.4   0.1    1.5  1  SUI1      Translation initiation factor SUI1


Domain annotation for each model (and alignments):
>> SUI1  Translation initiation factor SUI1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.4   0.1   1.8e-19   3.2e-15       2      77 .]      23     114 ..      22     114 .. 0.84

  Alignments for each domain:
  == domain 1  score: 56.4 bits;  conditional E-value: 1.8e-19
        SUI1   2 kpkihirleqrggrKkvTtvsgleafgid........lkklakelkkkfacsgsvvkdg..g.......eeiqvQGdqrkkvaelLtekygvp 77 
                 +p i++++e  +g+K++T+v+g+++  i+        +++l+k+lk+k+++s +++ ++  +         i++QG+++  ++++Lt++yg+p
  EFC35459.1  23 CPGISVEAEAIMGNKVITKVNGVKLL-INnsdlncvaFEDLVKKLKNKCSASIKTNTSNmpSvgggipeADITIQGNHIAMIEQILTQDYGFP 114
                 688********************444.4446677777*****************96633232445678899********************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       728  (0.0406046); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.55
# Mc/sec: 722.31
//
Query:       EFC35460.1  [L=104]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (104 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       660  (0.0368119); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.33s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 641.46
//
Query:       EFC35461.1  [L=451]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.2e-21   73.7   2.0    1.6e-20   72.5   2.0    1.7  1  PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.5   2.0   9.1e-25   1.6e-20       1      66 [.     306     382 ..     306     383 .. 0.89

  Alignments for each domain:
  == domain 1  score: 72.5 bits;  conditional E-value: 9.1e-25
  PhoLip_ATPase_N   1 vyindreene...........kkkyasNkIsTsKYtlltFlpknLfeqFrrvaNlYFLviailqliPqisplspvtt 66 
                      v+in+ e n+           +k+++sN+IsT+KYt+++F+ +nL++q+ ++ N+YF++++i  liP++sp++p+t+
       EFC35461.1 306 VHINNWELNSkatkkwflglrRKRFSSNYISTTKYTWWNFIILNLIYQLCKIGNIYFIITMIFALIPGVSPITPITA 382
                      57777665555667799999777***************************************************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       838  (0.0467399); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 2490.08
//
Query:       EFC35462.1  [L=246]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-07   32.0   0.4    3.8e-07   30.4   0.0    2.0  2  GHMP_kinases_C  GHMP kinases C terminal
    0.00067   19.8   0.0     0.0026   17.9   0.0    2.0  2  GHMP_kinases_N  GHMP kinases N terminal domain


Domain annotation for each model (and alignments):
>> GHMP_kinases_C  GHMP kinases C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.2      0.42   3.8e+03      12      31 ..      11      33 ..       6      38 .. 0.59
   2 !   30.4   0.0   4.2e-11   3.8e-07      13      80 ..     147     208 ..     137     225 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.42
  GHMP_kinases_C 12 llgellnlsqrs...elkavvgi 31
                     l++ ln+++ +   ++++v++ 
      EFC35462.1 11 NLNNNLNDNNLNkneTNENVLKY 33
                    46677777777665544445555 PP

  == domain 2  score: 30.4 bits;  conditional E-value: 4.2e-11
  GHMP_kinases_C  13 lgellnlsqrselkavvgilppeleellealselGalgaklsGaGgGptvfalfkdkdeaeqvaralr 80 
                     ++el+  ++   l++ +g  +p l+ +++++s++  l+akl+GaGgG++ f+l    ++ +++++  +
      EFC35462.1 147 MEELIDKNHS--LLNDIGTGHPKLDLICKIASKYN-LHAKLTGAGGGGCGFILL---NDINNIIDNNN 208
                     6899999***..89*********************.*****************9...44444554443 PP

>> GHMP_kinases_N  GHMP kinases N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   2.9e-07    0.0026      38      66 .]      26      61 ..      10      61 .. 0.78
   2 ?   -1.6   0.0      0.38   3.4e+03      38      55 ..     137     156 ..     120     161 .. 0.66

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.9e-07
                    H........HHHHHHHHHHHHHHHHHSHHHHHHHHSS CS
  GHMP_kinases_N 38 e........aklaleaerlaqggngsggDvaasvyGg 66
                    +        +++++  e l++ g +sg+D+++s++Gg
      EFC35462.1 26 TnenvlkyiNEWSYFVESLIH-GTPSGIDNSVSTFGG 61
                    1344666689***********.**************8 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.38
                     H...HHHHHHHHHHHHHHHHH CS
  GHMP_kinases_N  38 e...aklaleaerlaqggngs 55 
                         ++l l+ e+l+  +n s
      EFC35462.1 137 HlfsNELRLKMEELID-KNHS 156
                     1344888888888887.5544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1279  (0.0713369); expected 358.6 (0.02)
Passed bias filter:                      563  (0.0314016); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 1379.12
//
Query:       EFC35463.1  [L=641]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.017   15.9   5.9      0.017   15.9   5.9    2.7  2  Occludin_ELL  Occludin homology domain
       0.13   11.8   2.4         11    5.7   0.3    2.7  2  Ral           Antirestriction protein Ral
        1.8    9.1   5.7         16    6.1   0.1    3.3  4  DUF4473       Domain of unknown function (DUF4473)


Domain annotation for each model (and alignments):
>> Occludin_ELL  Occludin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.2      0.24   1.4e+03      31      57 ..     483     510 ..     478     531 .. 0.62
   2 ?   15.9   5.9   2.8e-06     0.017      19      85 ..     560     627 ..     559     635 .. 0.94

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.24
  Occludin_ELL  31 leevskkfseLerelkelkegsk.eykk 57 
                   +e+++k f+eL +  +++k++ + + ++
    EFC35463.1 483 IEKLKKVFTELAESADSYKKSAHtQSNE 510
                   6778888888888888877766643332 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 2.8e-06
  Occludin_ELL  19 keYkeYkelhaeleevskkfseLerelkelkegsk.eykkieeeilqeykklkkdpeyqekkkrceyL 85 
                   +eY++Yk  +++ + ++++ ++L+ e k  ++ +k ++kk++++++++y+ +k dpe+ e+ ++ ++L
    EFC35463.1 560 SEYSMYKLSKKDAKGLWHRERKLSVEYKGKRKANKeNHKKLHKKVIENYEYKKGDPEFTEETQQSTQL 627
                   68**************************998888879**************************99887 PP

>> Ral  Antirestriction protein Ral
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.3    0.0018        11      10      31 ..      58      79 ..      47      90 .. 0.90
   2 ?    5.1   0.1    0.0028        17       8      22 ..     454     470 ..     447     490 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0018
         Ral 10 wcsrfkkckGckldaecmvkPe 31
                wc + k  + c   +ec  k e
  EFC35463.1 58 WCCQIKYRNLCNYYSECAEKKE 79
                *****************98876 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0028
         Ral   8 nqwcsrfkkc..kGckl 22 
                 + wc++  kc  +Gck 
  EFC35463.1 454 DHWCGNHDKCygDGCKS 470
                 57********5456884 PP

>> DUF4473  Domain of unknown function (DUF4473)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.88   5.3e+03       3      25 ..     227     249 ..     225     258 .. 0.81
   2 ?   -3.4   0.0       2.5   1.5e+04      39      60 ..     382     403 ..     368     404 .. 0.70
   3 ?    4.2   0.2     0.011        64      43      75 ..     484     516 ..     469     523 .. 0.86
   4 ?    6.1   0.1    0.0027        16      16      56 ..     567     608 ..     567     618 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.88
     DUF4473   3 taeeakaeLvaaGlsekaadglv 25 
                 t+e  +++L  +Gl +  adgl 
  EFC35463.1 227 TDEALLENLKYMGLMKLMADGLS 249
                 66778889999999999999996 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.5
     DUF4473  39 kgdkeaakkafeklkaevdafi 60 
                  +   ++++++++++ +++++ 
  EFC35463.1 382 HDHDGSTRNIIHEHFPNAQEYL 403
                 4556788999999999999885 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.011
     DUF4473  43 eaakkafeklkaevdafiktqseeDqaaykafv 75 
                 e+ kk+f++l + +d + k+   +  +  ++ +
  EFC35463.1 484 EKLKKVFTELAESADSYKKSAHTQSNESLNNSM 516
                 7899****************9999888887755 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0027
     DUF4473  16 lsekaadglvkiaekfksefaka.kgdkeaakkafeklkaev 56 
                 ls+k a+gl+  + k   e++ + k +ke+ kk+ +k ++++
  EFC35463.1 567 LSKKDAKGLWHRERKLSVEYKGKrKANKENHKKLHKKVIENY 608
                 79999****************999*********999988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (641 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1373  (0.0765798); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.52
# Mc/sec: 3699.17
//
Query:       EFC35464.1  [L=233]
Description: hypothetical protein NAEGRDRAFT_76881 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (233 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       634  (0.0353617); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1357.18
//
Query:       EFC35465.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.1e-34  118.8   0.0    2.5e-34  118.6   0.0    1.0  1  AMP-binding  AMP-binding enzyme
  ------ inclusion threshold ------
      0.045   13.8   0.1      0.081   13.0   0.1    1.4  1  sCache_like  Single Cache-like


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.6   0.0   2.8e-38   2.5e-34       1     195 [.      57     246 ..      57     269 .. 0.78

  Alignments for each domain:
  == domain 1  score: 118.6 bits;  conditional E-value: 2.8e-38
                  HHHHHHHSTTSEEEEECCSTEEEEHHHHHHHHHHHHHHHHHTTSSTT-EEEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHHTESEE CS
  AMP-binding   1 leeqaaktpdkvalvdsgegqtlTYreldervnrlAagLrslGvkkgdrVaillpnspewvvallailkaGavvvplnptltaeelayiledseakvl 98 
                  ++eqa++tpd++ +vd   ++++T+++l++ +n+l+++L+++G+k++++V i+ ++s+  v+a+l +lk Ga+  +l+p+++a+++  +le s ++++
   EFC35465.1  57 FQEQAKQTPDRITMVD--NHESVTFEQLNRVSNQLSRHLLHKGLKRQEVVTIFGHRSCPVVLAILSTLKCGAIFNMLDPAYPADRIITCLEVSTPSAV 152
                  89*************9..99********************99******************************************************** PP

                  E......ETCTCCCHHHHHHHHSCC-EECEEEEESCCS-HCCHCCCHCCCCSCTTS-TSCCCS-BTTSEEEEEEE--SSSS-EEEEEEHHHHHHHHHH CS
  AMP-binding  99 i......atvdselleklleaaakleavklvivldadellkeeelkeeeeseekaekpeeeeelkpddlayiiYTSGTTGkPKGVmlshrnlvanvas 190
                  i      +      l+k+  +  + e +k v+vl++     +e+++++ ++++ +e+p+ ++++++dd a+  YTSG+TG PKGV  +h+ l++ + +
   EFC35465.1 153 IlieaagQ------LPKSVIDFIN-ENTKFVTVLKSMTDILNENVYSDYNDSNLSEDPTLNVKITQDDFAVCTYTSGSTGIPKGVLGRHGPLTHYYPW 243
                  *6654221......2222222221.233333333333222222333322222222245677899***************************9998766 PP

                  HHHHH CS
  AMP-binding 191 lklet 195
                  +k  +
   EFC35465.1 244 MK--Q 246
                  54..3 PP

>> sCache_like  Single Cache-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   9.1e-06     0.081      34      88 ..      55     106 ..      42     111 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 9.1e-06
                  HHHHHHHHHHT-EEEEEETTS-EEEETTS...S---HHHHHHHHTT--......EE CS
  sCache_like  34 kvleeasekldaritivdadgkvlydtgqeieeaeseavikellskee.rskevvi 88 
                  ++++e  ++ + rit+vd+++ v +++ +    + s++  + ll k   r+++v+i
   EFC35465.1  55 EIFQEQAKQTPDRITMVDNHESVTFEQLN----RVSNQLSRHLLHKGLkRQEVVTI 106
                  5789999999****************999....56666666666666655556655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 1547.76
//
Query:       EFC35466.1  [L=156]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.1e-09   37.4   0.1    2.9e-06   27.1   0.0    2.1  2  Abhydrolase_1  alpha/beta hydrolase fold
    4.5e-08   32.6   0.0    6.1e-06   25.7   0.0    2.1  2  Hydrolase_4    Serine aminopeptidase, S33
    6.2e-08   32.4   0.0    3.7e-05   23.3   0.0    2.0  2  Peptidase_S9   Prolyl oligopeptidase family
    0.00018   21.2   0.0    0.00019   21.1   0.0    1.1  1  FSH1           Serine hydrolase (FSH1)
    0.00036   20.2   0.1     0.0018   17.8   0.1    1.9  1  DLH            Dienelactone hydrolase family
    0.00041   20.2   0.1      0.018   14.9   0.0    2.0  2  Abhydrolase_2  Phospholipase/Carboxylesterase
     0.0048   17.0   0.0     0.0085   16.2   0.0    1.3  1  Abhydrolase_4  TAP-like protein
  ------ inclusion threshold ------
      0.015   15.2   0.1       0.68    9.8   0.0    2.1  2  BAAT_C         BAAT / Acyl-CoA thioester hydrolase C terminal
      0.021   14.3   0.0       0.14   11.6   0.0    1.9  1  Esterase_phd   Esterase PHB depolymerase
      0.081   13.5   0.0        7.8    7.0   0.0    2.0  2  Abhydrolase_6  Alpha/beta hydrolase family
      0.095   10.9   0.0       0.13   10.5   0.0    1.1  1  3HBOH          3HB-oligomer hydrolase (3HBOH)
       0.16   11.8   0.0       0.51   10.2   0.0    1.7  2  Abhydrolase_3  alpha/beta hydrolase fold


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0   0.00096       1.4      68      95 ..      16      43 ..       3      60 .. 0.82
   2 !   27.1   0.0   1.9e-09   2.9e-06     206     255 ..      78     134 ..      63     136 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00096
                   HHCTTSSEEEEEETHHHHHHHHHHHHHG CS
  Abhydrolase_1 68 dalgddkltlvGhSmGGmialayaaeyp 95
                   ++ +   +++ G S G+  ++++a++yp
     EFC35466.1 16 EKIDPADIVIFGISIGTGPSSYLAEKYP 43
                   556677899*****************97 PP

  == domain 2  score: 27.1 bits;  conditional E-value: 1.9e-09
                    C......THHHHSEEEEEEETTCSSSCH.HHHHHHHHCHTSEEEEEEETCSSSHHHH CS
  Abhydrolase_1 206 e......lknvlaptlvisgtsDplvpp.kaledlaqllpkkrlvvisdagHlafle 255
                    +      ++n++aptl+i+g+ D +vp+ + +e ++++ +k + +++++a H+++++
     EFC35466.1  78 MfcnihkVSNIKAPTLIIHGDRDSIVPYsHGKEIYENAKNKFKFITVPGADHNDIFD 134
                    244445599********************************9999999****99886 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0    0.0065       9.8      69     111 ..      12      54 ..       1      75 [. 0.78
   2 !   25.7   0.0   4.1e-09   6.1e-06     186     233 ..      84     130 ..      80     135 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0065
  Hydrolase_4  69 vkeehpel..plfllGhSmGGliallyllrypdkvaglilsaPal 111
                  ++++++     ++++G S G   +  ++++yp    glil  P+ 
   EFC35466.1  12 LVNNEKIDpaDIVIFGISIGTGPSSYLAEKYPV--GGLILQTPLK 54 
                  554444444589*******************99..9999999874 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 4.1e-09
  Hydrolase_4 186 raakitlPllllhGeaDkvvdpeasrelyerlgskdktlklypglyHe 233
                  ++++i++P+l++hG++D +v+++  +e+ye+++  + ++ + pg+ H 
   EFC35466.1  84 KVSNIKAPTLIIHGDRDSIVPYSHGKEIYENAKN-KFKFITVPGADHN 130
                  56789****************************7.8899999999997 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0    0.0019       2.9      50      74 ..       7      31 ..       2      43 .. 0.91
   2 !   23.3   0.0   2.5e-08   3.7e-05     130     187 ..      78     130 ..      72     151 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0019
                  HHHHHHHHTTS--GGGEEEEEETHH CS
  Peptidase_S9 50 aaaealakegyvdserlaitGgSyG 74
                  aa  +l++++ +d+  ++i+G S G
    EFC35466.1  7 AAYNYLVNNEKIDPADIVIFGISIG 31
                  7889*******************99 PP

  == domain 2  score: 23.3 bits;  conditional E-value: 2.5e-08
                   HHHHH-CGGG-----EEEEEEETT-SSS-THHHHHHHHHHH--S-SEEEEEETTS-SS CS
  Peptidase_S9 130 elspyspldnvkaypplLlihGlaDdrvppaealklvaaLqkkgknvlllifpdegHg 187
                    + +++++ n  +++p+L+ihG+ D+ vp++++ +++++ +   +++++ + p+++H 
    EFC35466.1  78 MFCNIHKVSN--IKAPTLIIHGDRDSIVPYSHGKEIYENAK---NKFKFITVPGADHN 130
                   4556666777..9**********************998654...57***********4 PP

>> FSH1  Serine hydrolase (FSH1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   1.3e-07   0.00019     151     199 ..      76     127 ..       2     130 .. 0.69

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 1.3e-07
        FSH1 151 yeeyy...eedkiqtptLhvlGelDtvvdeerseaLaeafknsskvlkHpgg 199
                 y+ +    + ++i+ ptL ++G++D++v+ +  ++++e+ kn+ k+++ pg+
  EFC35466.1  76 YDMFCnihKVSNIKAPTLIIHGDRDSIVPYSHGKEIYENAKNKFKFITVPGA 127
                 3333344466788*****************************9999999885 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.1   1.2e-06    0.0018      82     187 ..       5     129 ..       1     147 [. 0.76

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.2e-06
         DLH  82 lkaavaylksvpevstkkvgvvGfCmGGalalllaaevpevdaavafYG.......................lspekeleeaakikapilalfgeeDef 157
                 ++aa +yl ++++ ++  +++ G  +G   + +la + p v + +   +                         +  +++++ +ikap l+++g++D +
  EFC35466.1   5 AEAAYNYLVNNEKIDPADIVIFGISIGTGPSSYLAEKYP-VGGLILQTPlksilhvglgrsflapivpfmrpYDMFCNIHKVSNIKAPTLIIHGDRDSI 102
                 566777777777777777777777777777777777775.7777766667777777777777777776655545556788999**************** PP

         DLH 158 ipadevekleealkaanvdlelkvYpgagH 187
                 +p ++ +++ e+    + ++++   pga+H
  EFC35466.1 103 VPYSHGKEIYENA---KNKFKFITVPGADH 129
                 ****988888776...77889999999999 PP

>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.028        42     100     127 ..      16      43 ..       4      63 .. 0.82
   2 !   14.9   0.0   1.2e-05     0.018     153     199 ..      86     129 ..      66     146 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.028
                    TT--GGGEEEEEETHHHHHHHHHHHT-S CS
  Abhydrolase_2 100 kgipssriiigGFSqGaalalylaltlp 127
                    + i+  +i+i+G S G+  + yla ++p
     EFC35466.1  16 EKIDPADIVIFGISIGTGPSSYLAEKYP 43 
                    34999***********987777766554 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 1.2e-05
                    GGGG-EEEEEEETT-SSS-HHHHHHHHHHHHTTS-GEEEEEETT--S CS
  Abhydrolase_2 153 vtkklpilqiHgeeDpvvplalgkaakevlkkllkkvelksyeglaH 199
                    ++ k p l iHg+ D +vp+++gk+ +e  k+  k   + +++g  H
     EFC35466.1  86 SNIKAPTLIIHGDRDSIVPYSHGKEIYENAKNKFK---FITVPGADH 129
                    446899*****************998887665444...666665555 PP

>> Abhydrolase_4  TAP-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   5.7e-06    0.0085      34      76 ..      89     132 ..      74     138 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 5.7e-06
  Abhydrolase_4  34 aapvLllqnerDpaTPyegakklakalgg.avlvtvegeGHgal 76 
                    +ap+L++ + rD ++Py+ +k++ ++ ++  + +tv g++H+ +
     EFC35466.1  89 KAPTLIIHGDRDSIVPYSHGKEIYENAKNkFKFITVPGADHNDI 132
                    58*************************9978**********876 PP

>> BAAT_C  BAAT / Acyl-CoA thioester hydrolase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00046      0.68       7      43 ..       6      42 ..       2      48 .. 0.89
   2 ?    3.5   0.0     0.038        57     110     162 ..      84     130 ..      80     145 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00046
                HHHHHHHHCSTTB--SSEEEEEETHHHHHHHHHHHHS CS
      BAAT_C  7 eeainyllrhpkvkkdkigllGiSkGgelalllasfl 43
                e a+nyl +++k+   +i + GiS G     +la ++
  EFC35466.1  6 EAAYNYLVNNEKIDPADIVIFGISIGTGPSSYLAEKY 42
                88************************98888887766 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.038
                 -GGG--SEEEEEEETT-SSS-HHHHHHHHHHHHHCTT--.--EEEEETTB-S- CS
      BAAT_C 110 pvekakgpillvvgedDknwpSkesaekaserLkkagkkvevqlltYpkaGHl 162
                 +v ++k+p l++ g  D ++p ++   ++     ++ k+ + + +t p+a H+
  EFC35466.1  84 KVSNIKAPTLIIHGDRDSIVPYSHGK-EIY----ENAKN-KFKFITVPGADHN 130
                 78999**************9966544.333....33333.4555555666665 PP

>> Esterase_phd  Esterase PHB depolymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   9.7e-05      0.14      87     184 ..      11     104 ..       4     116 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.7e-05
  Esterase_phd  87 alvdehrvdaarvyvaGlsaGaaladllalhypd..vfaavalhsGlalGeaadvisaldvmrrGlrqapaaavdalveagaypglpalvvqGdadt 181
                    lv++ ++d+a + + G+s G++ ++ la +yp         l+s l +G   + ++ +  + r           + ++       p+l+++Gd d 
    EFC35466.1  11 YLVNNEKIDPADIVIFGISIGTGPSSYLAEKYPVggLILQTPLKSILHVGLGRSFLAPIVPFMRPYDMFCNIHKVSNIK------APTLIIHGDRDS 101
                   689999***************************5224666778888888888887766554443333333333333333......489999999998 PP

  Esterase_phd 182 vva 184
                   +v 
    EFC35466.1 102 IVP 104
                   875 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0    0.0052       7.8      55     112 ..      11      73 ..       2      79 .. 0.55
   2 ?    5.6   0.0     0.014        21     161     208 ..      80     131 ..      64     140 .. 0.67

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0052
                    HHHCCTT..TTSEEEEEETCHHHHHHH.HHHCC..EE.EEES-.......----TTTS----TTH CS
  Abhydrolase_6  55 alldelaagggpvvlvGHSlGGalala.aaplalvvg.vlldppp.....talpagllaaalell 112
                     l++ ++ ++ ++v++G S G+  ++  a +++ v g +l  p       ++l+ ++la++++++
     EFC35466.1  11 YLVNNEKIDPADIVIFGISIGTGPSSYlAEKYP-VGGlILQTP-LksilhVGLGRSFLAPIVPFM 73 
                    4555555589999********765555033344.455555555.223333333333355544444 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.014
                    TTCCHHTT-TTGCEEE.CTT-CHHHHCHHCCCH.....STTEEETCE...SSS.- CS
  Abhydrolase_6 161 lpaaawadlpvpllvl.ggeDplvprllerlla.....qagarlpvvlpgaGH.l 208
                     + + +  + +p+l++ g++D +vp  + +        ++++++ +++pga+H  
     EFC35466.1  80 CNIHKVSNIKAPTLIIhGDRDSIVP--YSHGKEiyenaKNKFKF-ITVPGADHnD 131
                    3466778888899888678899888..44333333555588888.********52 PP

>> 3HBOH  3HB-oligomer hydrolase (3HBOH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   8.6e-05      0.13     553     604 ..      89     133 ..      79     144 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 8.6e-05
       3HBOH 553 gkPaiivqGRaDallPvnhtsRpYlglnkkvegaasrlsyievtnaqhfDaf 604
                 + P++i++G  D+++P +h    Y       e a++++++i v  a+h D f
  EFC35466.1  89 KAPTLIIHGDRDSIVPYSHGKEIY-------ENAKNKFKFITVPGADHNDIF 133
                 46**************99987666.......677889999999999999987 PP

>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   0.00034      0.51      49      83 ..       2      33 ..       1      58 [. 0.86
   2 ?   -0.7   0.0      0.73   1.1e+03     167     207 ..      90     129 ..      63     131 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00034
                   HHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHH CS
  Abhydrolase_3 49 vedalaalrwlaeqawelgadpsrivlaGdSaGGn 83
                   +e a aa+++l+++    ++dp+ iv++G S G  
     EFC35466.1  2 YESAEAAYNYLVNN---EKIDPADIVIFGISIGTG 33
                   788999*******9...59*************976 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.73
                    --EEEEEETT-TTHHHHHHHHHHHHHTT--EEEEEETTEET CS
  Abhydrolase_3 167 pptlvvvaefDplrdegeayaerlraagvevelieyegmvH 207
                    +ptl++ +++D +   +    e  + a+++ ++i ++g+ H
     EFC35466.1  90 APTLIIHGDRDSIVPYSH-GKEIYENAKNKFKFITVPGADH 129
                    688888888887765443.2444455666666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       407  (0.0227007); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.57u 0.35s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 892.47
//
Query:       EFC35467.1  [L=188]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.7e-08   33.6   0.2    8.3e-05   22.4   0.1    2.5  2  Mito_carr        Mitochondrial carrier protein
  ------ inclusion threshold ------
      0.063   13.5   1.3        4.9    7.5   0.1    2.8  2  DUF3938          Protein of unknown function (DUF3938)
       0.11   12.4   0.7       0.22   11.4   0.1    1.9  2  CDP-OH_P_tran_2  CDP-alcohol phosphatidyltransferase 2
        1.2    9.3   5.3        3.6    7.8   0.2    3.2  4  NiFe_hyd_3_EhaA  NiFe-hydrogenase-type-3 Eha complex subunit 


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0   0.00032       1.4      48      80 ..      46      79 ..      16      84 .. 0.70
   2 !   22.4   0.1   1.8e-08   8.3e-05      15      81 ..     112     170 ..     104     184 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00032
                HHHHHHHHHHHHHH.HGGGTTHHHHHHHHHHHHH CS
   Mito_carr 48 ildvlkkiykeeGl.rglyrGllpnllrvapasa 80
                  + l+k++  +G+  gl+rG++p+l+ +   + 
  EFC35467.1 46 WKEELGKVITLNGMfGGLFRGIIPQLIANYLVNI 79
                45668899999998577*********98876665 PP

  == domain 2  score: 22.4 bits;  conditional E-value: 1.8e-08
                 HHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHH CS
   Mito_carr  15 agavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasal 81 
                  g++a+lv +P+ ++  r+q++++ +       + d++++ + +eG++g y G+   l+ ++ +++l
  EFC35467.1 112 IGVAAGLVSYPFTTLSLRMQMNPEVA-------MGDIISE-MTNEGISGIYAGFATHLVANILTAVL 170
                 467777889***************96.......4566666.569**************999987766 PP

>> DUF3938  Protein of unknown function (DUF3938)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1    0.0078        35      41      79 ..      56      95 ..      22     109 .. 0.77
   2 ?    7.5   0.1    0.0011       4.9      43      66 ..     110     133 ..     104     173 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0078
     DUF3938 41 lltmi.givggclsysitnyalvlqlssaffhglwawfia 79
                l  m  g+  g +   i+ny + +   s  f gl    i+
  EFC35467.1 56 LNGMFgGLFRGIIPQLIANYLVNIVNRSNVFNGLVIPGIS 95
                3344425677899999********999*****99766555 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0011
     DUF3938  43 tmigivggclsysitnyalvlqls 66 
                  mig+  g +sy +t  +l +q+ 
  EFC35467.1 110 VMIGVAAGLVSYPFTTLSLRMQMN 133
                 7****************9999986 PP

>> CDP-OH_P_tran_2  CDP-alcohol phosphatidyltransferase 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       2.5   1.1e+04      14      21 ..      21      28 ..      21      29 .. 0.86
   2 ?   11.4   0.1     5e-05      0.22      13      27 ..     114     128 ..     110     130 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.5
  CDP-OH_P_tran_2 14 aAlLityP 21
                     +A++it P
       EFC35467.1 21 MATIITHP 28
                     79999988 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 5e-05
  CDP-OH_P_tran_2  13 faAlLityPWltLsv 27 
                      +aA L++yP+ tLs+
       EFC35467.1 114 VAAGLVSYPFTTLSL 128
                      79***********96 PP

>> NiFe_hyd_3_EhaA  NiFe-hydrogenase-type-3 Eha complex subunit A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.61   2.7e+03      56      67 ..       7      18 ..       2      34 .. 0.51
   2 ?    2.3   0.0     0.042   1.9e+02      65      93 ..      51      79 ..      46      83 .. 0.78
   3 ?   -1.5   0.0      0.61   2.7e+03      72      87 ..     110     125 ..     100     136 .. 0.64
   4 ?    7.8   0.2    0.0008       3.6      54      94 ..     137     178 ..     125     181 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.61
  NiFe_hyd_3_EhaA 56 Gllalvfklgve 67
                     Gl al++k+++ 
       EFC35467.1  7 GLKALLMKFSMG 18
                     555555554333 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.042
  NiFe_hyd_3_EhaA 65 gve.iydGlllaiiiGvlsalfskyllekv 93
                     g   +++G+  +++ G++  l+++yl++ +
       EFC35467.1 51 GKViTLNGMFGGLFRGIIPQLIANYLVN-I 79
                     555467899999*************954.4 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.61
  NiFe_hyd_3_EhaA  72 lllaiiiGvlsalfsk 87 
                      +++++ +G++s  f+ 
       EFC35467.1 110 VMIGVAAGLVSYPFTT 125
                      4556666666655544 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.0008
  NiFe_hyd_3_EhaA  54 alG.llalvfklgve.iydGlllaiiiGvlsalfskyllekvf 94 
                      a+G +++ +++ g++ iy G    +++ +l+a++ k+l + v+
       EFC35467.1 137 AMGdIISEMTNEGISgIYAGFATHLVANILTAVLHKFL-DLVI 178
                      555455556666777799******************98.6555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (188 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       417  (0.0232584); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.36s 00:00:00.91 Elapsed: 00:00:00.53
# Mc/sec: 1062.41
//
Query:       EFC35468.1  [L=289]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.096   12.9   0.1       0.19   11.9   0.1    1.4  1  DUF2703     Domain of unknown function (DUF2703)
       0.73    9.5  14.2      0.064   13.0   9.4    1.7  2  Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
        1.7    8.7   6.1        1.1    9.2   4.3    1.6  2  DUF4484     Domain of unknown function (DUF4484)
        3.7    6.8   8.9        6.2    6.0   8.9    1.3  1  NOA36       NOA36 protein
        7.8    6.6   7.9        5.3    7.1   2.6    2.7  2  PDE8        PDE8 phosphodiesterase


Domain annotation for each model (and alignments):
>> DUF2703  Domain of unknown function (DUF2703)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   5.2e-05      0.19      15      73 ..     215     271 ..     206     282 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.2e-05
     DUF2703  15 CercgeTgktleeavkelkeaLealgievelekvelseeelareflesntilingrple 73 
                  ++ ++ ++++++ +++l++++++   +++le+++++++e +   l+++++ ++gr ++
  EFC35468.1 215 PKKSTTSKRNFDNTLETLSKVYSPKQNNINLETITIPKKEYE--DLKTDNVILQGRLIQ 271
                 5667778899*******************************9..99*********9984 PP

>> Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   9.4   1.8e-05     0.064      78     157 ..      48     128 ..       5     130 .. 0.47
   2 ?   -2.3   0.2       0.8   2.9e+03      76      76 ..     216     216 ..     159     262 .. 0.57

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.8e-05
                 ------------------------------..----------------------------------------.-------- CS
  Cwf_Cwc_15  78 eeeeekekkeeeeeeeeeeakrrkeelleeareidaddedseeeeeeeeeesdddsdsdsdddddedetaeL.lrELekik 157
                 +++++++++ ++++++++e  + + +l++  ++    ++ + ++++++ ++s++ +d+++d+dd+e+e++ L l  L+k++
  EFC35468.1  48 SSNTNNNTSISSNNSNTNEGLKINMSLIKAFNDSGTSENLNLNNSNDNINNSSKRDDDSDDEDDEENEDELLtLSSLAKLR 128
                 111122222222222223333333334433333333333333333333344444444444555555555554245677766 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.8
                 - CS
  Cwf_Cwc_15  76 e 76 
                 +
  EFC35468.1 216 K 216
                 1 PP

>> DUF4484  Domain of unknown function (DUF4484)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   4.3   0.00031       1.1      39     165 ..      30     175 ..      10     181 .. 0.57
   2 ?   -1.9   0.0      0.79   2.8e+03      30      62 ..     187     223 ..     178     253 .. 0.44

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00031
     DUF4484  39 LLadlapastsvsas.slaslaaeeeseereeaeeeeeeeearkelaiiaYFhrLTtqilsvladivdssdeekeddeddeeeldeeeedeeeee.... 132
                  L+   p+++s+s s + +s ++   ++++ ++++++++e  ++++ +i  F+   t+    l++  d+ ++++++d+d+++e+dee+ede   +    
  EFC35468.1  30 ALNIPGPSESSISSSpKQSSNTN---NNTSISSNNSNTNEGLKINMSLIKAFNDSGTSENLNLNNSNDNINNSSKRDDDSDDEDDEENEDELL-Tlssl 124
                 23222344444443312333333...3333344455577899********9998776654455544444444333333333333332222222.13567 PP

     DUF4484 133 ..................eeaeeeeeepLleeaesaeeeeeedevvridse 165
                                   + ae +++ ++l+ ++ ++++++++++v+++se
  EFC35468.1 125 aklrklipripklippdeNGAERSSTLNMLNLTSPKKSSNNSRGIVSLTSE 175
                 889999999999999976566666666777777888889999999999887 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.79
     DUF4484  30 eeeeaqdaaLLadlapa....stsvsasslaslaaee 62 
                  +++++d ++L d++p       s+s+s  +s+++++
  EFC35468.1 187 LDSKRTDLSILLDNEPGdhfnVFSLSNSPKKSTTSKR 223
                 4555567777766544333332233333223333311 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   8.9    0.0017       6.2     254     297 ..      73     116 ..      36     122 .. 0.42

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0017
       NOA36 254 sdydaylkalasgddeddegdedddddddeedddeeeddedeee 297
                 s  +a++++ +s++ + ++++++ ++ ++ +dd+++edde++e+
  EFC35468.1  73 SLIKAFNDSGTSENLNLNNSNDNINNSSKRDDDSDDEDDEENED 116
                 22334444444433333333333333333333333333333333 PP

>> PDE8  PDE8 phosphodiesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   2.6    0.0015       5.3      19      45 ..      38      70 ..      36      72 .. 0.75
   2 ?    1.3   0.2     0.098   3.5e+02      23      40 ..     212     229 ..     210     233 .. 0.75

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0015
        PDE8 19 dSdeStSPrq...T...TtvSqgnaaplpGLFi 45
                +S  S+SP+q   T   T++S +n+++  GL i
  EFC35468.1 38 ESSISSSPKQssnTnnnTSISSNNSNTNEGLKI 70
                5666788887555234589***********977 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.098
        PDE8  23 StSPrqTTtvSqgnaapl 40 
                 S+SP++ Tt   +  ++l
  EFC35468.1 212 SNSPKKSTTSKRNFDNTL 229
                 9*****999666656665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (289 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1353  (0.0754643); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.36s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 1638.06
//
Query:       EFC35469.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1096  (0.06113); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 1943.29
//
Query:       EFC35470.1  [L=880]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-65  216.7 322.4    0.00022   21.5   9.6   23.1 23  EGF_2     EGF-like domain
    7.1e-07   29.6   8.1        1.5    9.0   0.0    6.6  9  B9-C2     Ciliary basal body-associated, B9 protein
    1.1e-06   28.8 251.9     0.0046   17.2   2.1   23.2 22  EGF       EGF-like domain
     0.0015   18.3   2.9         22    5.2   0.0    6.5  7  MORN      MORN repeat
  ------ inclusion threshold ------
      0.045   13.5   0.1       0.14   12.0   0.1    1.7  1  PYST-C1   Plasmodium yoelii subtelomeric region (PYST-C1)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   3.1    0.0062        22      20      32 .]       2      14 ..       1      14 [. 0.93
   2 !   13.3   3.9   2.2e-05     0.081       5      28 ..      27      49 ..      19      52 .. 0.83
   3 !   17.5   5.2   1.1e-06     0.004       7      32 .]      69      93 ..      65      93 .. 0.90
   4 !   13.6   8.9   1.8e-05     0.066       4      32 .]     105     132 ..     102     132 .. 0.90
   5 !   21.5   9.6   6.1e-08   0.00022       6      32 .]     146     171 ..     141     171 .. 0.88
   6 !   19.3   7.4     3e-07    0.0011       6      32 .]     185     210 ..     179     210 .. 0.93
   7 !   14.7   3.0   8.2e-06     0.029       4      28 ..     222     245 ..     215     248 .. 0.83
   8 !   16.4   6.1   2.5e-06    0.0088       7      32 .]     265     289 ..     260     289 .. 0.87
   9 !   13.9   7.9   1.4e-05     0.052       5      32 .]     302     328 ..     298     328 .. 0.90
  10 !   21.0   8.8   8.7e-08   0.00031       6      32 .]     342     367 ..     337     367 .. 0.88
  11 !   16.0   6.7   3.2e-06     0.012       4      32 .]     399     427 ..     397     427 .. 0.88
  12 !   21.2   9.1     8e-08   0.00029       5      32 .]     441     467 ..     437     467 .. 0.89
  13 !   16.0   4.2   3.3e-06     0.012       5      32 .]     480     506 ..     472     506 .. 0.84
  14 !   17.9   5.5   8.4e-07     0.003       6      32 .]     520     545 ..     516     545 .. 0.92
  15 !   12.5   7.4   4.1e-05      0.15       5      32 .]     558     584 ..     554     584 .. 0.87
  16 !   14.3   7.3   1.1e-05      0.04       6      32 .]     598     623 ..     593     623 .. 0.86
  17 !   14.8   7.6   7.9e-06     0.028       6      32 .]     638     663 ..     633     663 .. 0.90
  18 !   19.9   4.7     2e-07   0.00071       4      28 ..     674     698 ..     668     701 .. 0.87
  19 !   17.8   6.3   8.8e-07    0.0032       5      32 .]     716     742 ..     712     742 .. 0.88
  20 !   13.6   8.9   1.8e-05     0.066       4      32 .]     754     781 ..     751     781 .. 0.90
  21 !   18.6   9.7   4.9e-07    0.0017       6      32 .]     795     820 ..     790     820 .. 0.87
  22 !   15.4   8.1   5.1e-06     0.018       5      32 .]     833     859 ..     829     859 .. 0.91
  23 ?   -0.7   0.3      0.53   1.9e+03       3      12 ..     869     879 ..     864     880 .] 0.79

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0062
       EGF_2 20 qCdCdsgyqGktC 32
                 C C++gy+G +C
  EFC35470.1  2 TCTCQNGYTGVNC 14
                5**********99 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 2.2e-05
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyq 28
                +  C ghG Cv+    C C++gy+
  EFC35470.1 27 SHSCYGHGNCVDHD-LCICNDGYT 49
                567*******9777.9*******8 PP

  == domain 3  score: 17.5 bits;  conditional E-value: 1.1e-06
       EGF_2  7 iCgghGtCvnqcGqCdCdsgyqGktC 32
                 C+ hG+C +++ +C+C++g++ ++C
  EFC35470.1 69 VCSSHGQCLAPN-NCSCFDGFTFDNC 93
                5********999.8*******97777 PP

  == domain 4  score: 13.6 bits;  conditional E-value: 1.8e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+g G C +++ +C+C  ++ G +C
  EFC35470.1 105 NQSVCNGFGECYSPN-NCKCHENHIGLQC 132
                 3899*******9999.8*********999 PP

  == domain 5  score: 21.5 bits;  conditional E-value: 6.1e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G+C+ q ++C+C+s y+G +C
  EFC35470.1 146 QSCNGNGQCI-QYNECVCNSDYTGIDC 171
                 56********.6679************ PP

  == domain 6  score: 19.3 bits;  conditional E-value: 3e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG+C ++  qC+C  gy+G +C
  EFC35470.1 185 TVCSSHGVCQAPD-QCQCHEGYTGMQC 210
                 56********999.**********999 PP

  == domain 7  score: 14.7 bits;  conditional E-value: 8.2e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyq 28 
                 ++++C+ hG C++ +  C C +gy+
  EFC35470.1 222 NSSTCSFHGECIDHN-LCTCHDGYT 245
                 3789*******8666.9*******7 PP

  == domain 8  score: 16.4 bits;  conditional E-value: 2.5e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ hG+C +++ +C C++g++ ++C
  EFC35470.1 265 VCSSHGQCLAPN-NCTCFDGFTFDNC 289
                 6********999.8*******97777 PP

  == domain 9  score: 13.9 bits;  conditional E-value: 1.4e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G C +++ +C+C  ++ G +C
  EFC35470.1 302 SSVCSGFGECYSPN-NCKCHENHIGLQC 328
                 789*******9999.8*********999 PP

  == domain 10  score: 21.0 bits;  conditional E-value: 8.7e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  +C+g+G+C+ q ++C+C s y+G +C
  EFC35470.1 342 QACNGNGQCI-QYNECVCHSDYTGIDC 367
                 68********.6679************ PP

  == domain 11  score: 16.0 bits;  conditional E-value: 3.2e-06
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ hG+C +   +C+C+ g++G tC
  EFC35470.1 399 NdSNVCSSHGSCQSVD-ECQCQLGFTGLTC 427
                 55899*******9666.8************ PP

  == domain 12  score: 21.2 bits;  conditional E-value: 8e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++iC+ hG+Cvn    C+Cd+gy+G  C
  EFC35470.1 441 SSICSSHGKCVNWD-TCQCDTGYTGLEC 467
                 79*********777.9*********999 PP

  == domain 13  score: 16.0 bits;  conditional E-value: 3.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hG+C++ + +C+C ++y   +C
  EFC35470.1 480 SLVCSSHGSCIDHN-NCSCMPSYVDIDC 506
                 789*******9777.8*****9988888 PP

  == domain 14  score: 17.9 bits;  conditional E-value: 8.4e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG C +++ +C+C  g++ ++C
  EFC35470.1 520 LVCSSHGDCLSPN-NCSCHEGFTSDNC 545
                 57********999.8***********9 PP

  == domain 15  score: 12.5 bits;  conditional E-value: 4.1e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G C  ++ +C+C  ++ G +C
  EFC35470.1 558 SSVCSGFGECTFPN-NCKCHENHVGLQC 584
                 789*******9667.8*********999 PP

  == domain 16  score: 14.3 bits;  conditional E-value: 1.1e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G+C+ q ++C+C   ++G +C
  EFC35470.1 598 QSCNGNGQCI-QYNECVCHLDFTGLNC 623
                 56********.6679*********999 PP

  == domain 17  score: 14.8 bits;  conditional E-value: 7.9e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C  hG+C ++  qC+C  gy+G +C
  EFC35470.1 638 HVCFSHGVCQAPD-QCQCHEGYTGMQC 663
                 56999*****999.**********999 PP

  == domain 18  score: 19.9 bits;  conditional E-value: 2e-07
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyq 28 
                 + +++C+ hG C++++ +C+C +gy+
  EFC35470.1 674 NdSSTCSSHGECIEFN-NCSCHDGYT 698
                 46899********999.8*******7 PP

  == domain 19  score: 17.8 bits;  conditional E-value: 8.8e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ hG+C +++ +C+C+ gy+  +C
  EFC35470.1 716 SVVCSSHGQCLAPN-NCSCFEGYTAENC 742
                 568********999.8*******98888 PP

  == domain 20  score: 13.6 bits;  conditional E-value: 1.8e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+g G C +++ +C+C  ++ G +C
  EFC35470.1 754 NQSVCNGFGECYSPN-NCKCHENHIGLQC 781
                 3899*******9999.8*********999 PP

  == domain 21  score: 18.6 bits;  conditional E-value: 4.9e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G+C+ q ++C+C s+y+G +C
  EFC35470.1 795 QSCNGNGQCI-QYNECMCHSNYTGLNC 820
                 56********.6679*********999 PP

  == domain 22  score: 15.4 bits;  conditional E-value: 5.1e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C  hG+C ++  qC+C  gy+G +C
  EFC35470.1 833 QPVCFSHGICQKPD-QCQCHEGYTGMQC 859
                 67899******999.**********999 PP

  == domain 23  score: -0.7 bits;  conditional E-value: 0.53
       EGF_2   3 as.deiCgghG 12 
                 a+ +++C+ hG
  EFC35470.1 869 ANdSSTCSSHG 879
                 446899****9 PP

>> B9-C2  Ciliary basal body-associated, B9 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.7     6e+03      82     104 ..      59      81 ..      56      85 .. 0.88
   2 !    6.4   0.0    0.0027       9.7      82     111 ..      98     127 ..      94     144 .. 0.87
   3 ?   -2.3   0.0       1.2   4.3e+03      84     109 ..     178     203 ..     175     223 .. 0.79
   4 ?   -1.7   0.0      0.79   2.8e+03      82     104 ..     255     277 ..     251     282 .. 0.88
   5 !    5.1   0.0    0.0068        24      82     111 ..     294     323 ..     290     339 .. 0.87
   6 !    9.0   0.0   0.00042       1.5      82     112 ..     550     580 ..     546     590 .. 0.87
   7 ?   -3.2   0.0       2.4   8.5e+03      89     109 ..     636     656 ..     626     668 .. 0.75
   8 ?   -1.6   0.0      0.78   2.8e+03      82     105 ..     708     731 ..     704     744 .. 0.87
   9 !    6.6   0.0    0.0023       8.2      82     111 ..     747     776 ..     742     787 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.7
       B9-C2  82 VyslDswgrerveGYGvlalPts 104
                 +y+lDs +   + ++G +  P +
  EFC35470.1  59 CYGLDSSQLIVCSSHGQCLAPNN 81 
                 699***************99975 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0027
       B9-C2  82 VyslDswgrerveGYGvlalPtspGshelt 111
                 +y++D  +++ ++G+G +  P +  +he  
  EFC35470.1  98 CYNIDASNQSVCNGFGECYSPNNCKCHENH 127
                 6899********************999854 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.2
       B9-C2  84 slDswgrerveGYGvlalPtspGshe 109
                 + + ++   + ++Gv++ P +  +he
  EFC35470.1 178 GSNATNPTVCSSHGVCQAPDQCQCHE 203
                 56677888999********9999987 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.79
       B9-C2  82 VyslDswgrerveGYGvlalPts 104
                 +y+lDs ++  + ++G +  P +
  EFC35470.1 255 CYGLDSSQSMVCSSHGQCLAPNN 277
                 699***************99976 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.0068
       B9-C2  82 VyslDswgrerveGYGvlalPtspGshelt 111
                 +y++D  +++ + G+G +  P +  +he  
  EFC35470.1 294 CYNIDASNSSVCSGFGECYSPNNCKCHENH 323
                 6899********************999854 PP

  == domain 6  score: 9.0 bits;  conditional E-value: 0.00042
       B9-C2  82 VyslDswgrerveGYGvlalPtspGsheltv 112
                 +y++D  +++ + G+G +++P +  +he  v
  EFC35470.1 550 CYNIDASNSSVCSGFGECTFPNNCKCHENHV 580
                 6899*********************999544 PP

  == domain 7  score: -3.2 bits;  conditional E-value: 2.4
       B9-C2  89 grerveGYGvlalPtspGshe 109
                 ++  + ++Gv++ P +  +he
  EFC35470.1 636 QSHVCFSHGVCQAPDQCQCHE 656
                 567888999999999998887 PP

  == domain 8  score: -1.6 bits;  conditional E-value: 0.78
       B9-C2  82 VyslDswgrerveGYGvlalPtsp 105
                 +y+lDs ++  + ++G +  P + 
  EFC35470.1 708 CYGLDSSQSVVCSSHGQCLAPNNC 731
                 699***************999765 PP

  == domain 9  score: 6.6 bits;  conditional E-value: 0.0023
       B9-C2  82 VyslDswgrerveGYGvlalPtspGshelt 111
                 +y++D  +++ ++G+G +  P +  +he  
  EFC35470.1 747 CYNIDASNQSVCNGFGECYSPNNCKCHENH 776
                 7999********************999854 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.7     0.001       3.6      21      31 ..       2      12 ..       2      13 .. 0.90
   2 ?    3.5   6.6     0.025        89       6      29 ..      30      49 ..      19      50 .. 0.87
   3 !    6.4   1.8    0.0032        11       6      31 ..      70      91 ..      64      92 .. 0.90
   4 ?   -0.8   5.1      0.55     2e+03       4      30 ..     105     129 ..     103     131 .. 0.73
   5 !    6.8   5.5    0.0024       8.7       5      31 ..     144     169 ..     141     170 .. 0.86
   6 !   16.8   4.6   1.7e-06    0.0063       4      30 ..     183     207 ..     180     208 .. 0.90
   7 ?    4.7   3.9     0.011        39       4      29 ..     224     245 ..     219     246 .. 0.88
   8 !    7.4   2.4    0.0015       5.5       6      31 ..     266     287 ..     260     288 .. 0.87
   9 ?   -0.4   3.9      0.41   1.5e+03       6      30 ..     305     325 ..     299     327 .. 0.72
  10 !    8.1   5.1   0.00092       3.3       5      31 ..     342     365 ..     337     366 .. 0.85
  11 !   17.2   2.1   1.3e-06    0.0046       3      31 ..     401     425 ..     398     426 .. 0.86
  12 !   15.1   3.6   5.9e-06     0.021       6      30 ..     444     464 ..     436     466 .. 0.90
  13 ?    2.1   3.4     0.071   2.5e+02       6      24 ..     483     497 ..     472     503 .. 0.81
  14 !    5.0   4.1    0.0085        31       6      29 ..     522     541 ..     511     544 .. 0.84
  15 ?    0.0   3.7      0.31   1.1e+03       6      28 ..     561     579 ..     555     583 .. 0.77
  16 !    6.2   4.5    0.0036        13       5      31 ..     598     621 ..     593     622 .. 0.86
  17 !   12.4   4.4   4.2e-05      0.15       4      30 ..     638     660 ..     634     661 .. 0.87
  18 !    7.2   4.0    0.0018       6.4       4      29 ..     677     698 ..     672     699 .. 0.87
  19 !    8.3   2.1   0.00078       2.8       6      29 ..     719     738 ..     713     741 .. 0.89
  20 ?   -0.8   5.1      0.55     2e+03       4      30 ..     754     778 ..     752     780 .. 0.73
  21 !    8.8   6.4   0.00056         2       5      31 ..     793     818 ..     790     819 .. 0.85
  22 !   15.2   4.9   5.5e-06      0.02       4      30 ..     833     856 ..     830     857 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.001
                EEEECTTEEST CS
         EGF 21 tCiCpeGytGk 31
                tC+C++GytG 
  EFC35470.1  2 TCTCQNGYTGV 12
                7********95 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.025
                STTT-EEEEETTTEEEEEECTTEE CS
         EGF  6 CsngGtCvdtgrggytCiCpeGyt 29
                C ++G Cvd       CiC  Gyt
  EFC35470.1 30 CYGHGNCVDHD----LCICNDGYT 49
                ***********....********8 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0032
                STTT-EEEEETTTEEEEEECTTEEST CS
         EGF  6 CsngGtCvdtgrggytCiCpeGytGk 31
                Cs +G C+ +     +C C  G+t +
  EFC35470.1 70 CSSHGQCLAPN----NCSCFDGFTFD 91
                *******9999....********976 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 0.55
                 TT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytG 30 
                 n   C++ G+C ++     +C+C e   G
  EFC35470.1 105 NQsvCNGFGECYSP----NNCKCHENHIG 129
                 6677*******444....48999887665 PP

  == domain 5  score: 6.8 bits;  conditional E-value: 0.0024
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                     C+++G C+++     +C C + ytG+
  EFC35470.1 144 EtqsCNGNGQCIQYN----ECVCNSDYTGI 169
                 3347***********....*********97 PP

  == domain 6  score: 16.8 bits;  conditional E-value: 1.7e-06
                 TT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytG 30 
                 np  Cs +G C  +     +C+C eGytG
  EFC35470.1 183 NPtvCSSHGVCQAPD----QCQCHEGYTG 207
                 8889*******7777....*********9 PP

  == domain 7  score: 4.7 bits;  conditional E-value: 0.011
                 TTSTTT-EEEEETTTEEEEEECTTEE CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGyt 29 
                  +Cs +G+C+d       C+C  Gyt
  EFC35470.1 224 STCSFHGECIDHN----LCTCHDGYT 245
                 45999****9999....********8 PP

  == domain 8  score: 7.4 bits;  conditional E-value: 0.0015
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G C+ +     +C+C  G+t +
  EFC35470.1 266 CSSHGQCLAPN----NCTCFDGFTFD 287
                 *******9999....********976 PP

  == domain 9  score: -0.4 bits;  conditional E-value: 0.41
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 Cs+ G+C ++     +C+C e   G
  EFC35470.1 305 CSGFGECYSP----NNCKCHENHIG 325
                 99*****444....48999887665 PP

  == domain 10  score: 8.1 bits;  conditional E-value: 0.00092
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                   C+++G C+++     +C C + ytG+
  EFC35470.1 342 QaCNGNGQCIQYN----ECVCHSDYTGI 365
                 37***********....**********7 PP

  == domain 11  score: 17.2 bits;  conditional E-value: 1.3e-06
                 STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 +n Cs +G C ++     +C+C+ G+tG 
  EFC35470.1 401 SNVCSSHGSCQSVD----ECQCQLGFTGL 425
                 366*******8888....**********6 PP

  == domain 12  score: 15.1 bits;  conditional E-value: 5.9e-06
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 Cs +G+Cv+      tC+C++GytG
  EFC35470.1 444 CSSHGKCVNWD----TCQCDTGYTG 464
                 *******9999....*********9 PP

  == domain 13  score: 2.1 bits;  conditional E-value: 0.071
                 STTT-EEEEETTTEEEEEE CS
         EGF   6 CsngGtCvdtgrggytCiC 24 
                 Cs +G C+d      +C C
  EFC35470.1 483 CSSHGSCIDHN----NCSC 497
                 *******9987....7777 PP

  == domain 14  score: 5.0 bits;  conditional E-value: 0.0085
                 STTT-EEEEETTTEEEEEECTTEE CS
         EGF   6 CsngGtCvdtgrggytCiCpeGyt 29 
                 Cs +G C+++     +C C eG+t
  EFC35470.1 522 CSSHGDCLSPN----NCSCHEGFT 541
                 *******9999....********8 PP

  == domain 15  score: 0.0 bits;  conditional E-value: 0.31
                 STTT-EEEEETTTEEEEEECTTE CS
         EGF   6 CsngGtCvdtgrggytCiCpeGy 28 
                 Cs+ G+C  +     +C+C e  
  EFC35470.1 561 CSGFGECTFPN----NCKCHENH 579
                 *******7777....79999875 PP

  == domain 16  score: 6.2 bits;  conditional E-value: 0.0036
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                   C+++G C+++     +C C   +tG 
  EFC35470.1 598 QsCNGNGQCIQYN----ECVCHLDFTGL 621
                 37***********....9********96 PP

  == domain 17  score: 12.4 bits;  conditional E-value: 4.2e-05
                 TTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytG 30 
                 + C  +G C  +     +C+C eGytG
  EFC35470.1 638 HVCFSHGVCQAPD----QCQCHEGYTG 660
                 55*******7777....*********9 PP

  == domain 18  score: 7.2 bits;  conditional E-value: 0.0018
                 TTSTTT-EEEEETTTEEEEEECTTEE CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGyt 29 
                  +Cs +G+C++      +C C  Gyt
  EFC35470.1 677 STCSSHGECIEFN----NCSCHDGYT 698
                 46*******9999....********8 PP

  == domain 19  score: 8.3 bits;  conditional E-value: 0.00078
                 STTT-EEEEETTTEEEEEECTTEE CS
         EGF   6 CsngGtCvdtgrggytCiCpeGyt 29 
                 Cs +G C+ +     +C C eGyt
  EFC35470.1 719 CSSHGQCLAPN----NCSCFEGYT 738
                 *******9999....********8 PP

  == domain 20  score: -0.8 bits;  conditional E-value: 0.55
                 TT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytG 30 
                 n   C++ G+C ++     +C+C e   G
  EFC35470.1 754 NQsvCNGFGECYSP----NNCKCHENHIG 778
                 6677*******444....48999887665 PP

  == domain 21  score: 8.8 bits;  conditional E-value: 0.00056
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                     C+++G C+++     +C C + ytG 
  EFC35470.1 793 EtqsCNGNGQCIQYN----ECMCHSNYTGL 818
                 3347***********....**********6 PP

  == domain 22  score: 15.2 bits;  conditional E-value: 5.5e-06
                 TT.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytG 30 
                 +p C  +G+C  +     +C+C eGytG
  EFC35470.1 833 QPvCFSHGICQKPD----QCQCHEGYTG 856
                 579*******5555....9********9 PP

>> MORN  MORN repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.046   1.7e+02      10      22 ..     109     121 ..     106     122 .. 0.88
   2 ?   -1.6   0.0      0.88   3.1e+03      13      22 ..     190     199 ..     187     200 .. 0.85
   3 ?    1.0   0.0      0.13   4.7e+02      10      22 ..     305     317 ..     304     318 .. 0.87
   4 !    5.2   0.0    0.0061        22      10      22 ..     561     573 ..     559     574 .. 0.88
   5 ?   -2.1   0.0       1.3   4.7e+03      13      22 ..     643     652 ..     643     653 .. 0.87
   6 ?    2.4   0.0     0.046   1.7e+02      10      22 ..     758     770 ..     755     771 .. 0.88
   7 ?   -3.0   0.0       2.5   8.9e+03      13      22 ..     839     848 ..     839     849 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.046
        MORN  10 rhGkGvytwpdGd 22 
                 ++G+G ++ p+ +
  EFC35470.1 109 CNGFGECYSPNNC 121
                 79*********87 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.88
        MORN  13 kGvytwpdGd 22 
                 +Gv++ pd +
  EFC35470.1 190 HGVCQAPDQC 199
                 8****99986 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.13
        MORN  10 rhGkGvytwpdGd 22 
                 + G+G ++ p+ +
  EFC35470.1 305 CSGFGECYSPNNC 317
                 67*********87 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0061
        MORN  10 rhGkGvytwpdGd 22 
                 + G+G +t+p+ +
  EFC35470.1 561 CSGFGECTFPNNC 573
                 68*********97 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 1.3
        MORN  13 kGvytwpdGd 22 
                 +Gv++ pd +
  EFC35470.1 643 HGVCQAPDQC 652
                 8****99986 PP

  == domain 6  score: 2.4 bits;  conditional E-value: 0.046
        MORN  10 rhGkGvytwpdGd 22 
                 ++G+G ++ p+ +
  EFC35470.1 758 CNGFGECYSPNNC 770
                 79*********87 PP

  == domain 7  score: -3.0 bits;  conditional E-value: 2.5
        MORN  13 kGvytwpdGd 22 
                 +G+++ pd +
  EFC35470.1 839 HGICQKPDQC 848
                 799**99986 PP

>> PYST-C1  Plasmodium yoelii subtelomeric region (PYST-C1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   3.8e-05      0.14      16      39 ..     375     398 ..     373     403 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3.8e-05
     PYST-C1  16 InrsNekndIeskhetqLkNnNpk 39 
                 In +N kn I s++et+L  n p 
  EFC35470.1 375 INATNQKNHIGSQCETPLCYNIPA 398
                 9*****************877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (880 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       396  (0.0220871); expected 358.6 (0.02)
Passed bias filter:                       82  (0.0045736); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.99u 0.31s 00:00:01.30 Elapsed: 00:00:00.54
# Mc/sec: 4911.71
//
Query:       EFC35471.1  [L=102]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.1e-05   23.1   0.0    5.5e-05   23.0   0.0    1.1  1  Phage_integrase  Phage integrase family


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0     3e-09   5.5e-05     107     162 ..      24      78 ..       2      86 .. 0.80

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 3e-09
                      -HHHHHHHHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHHHHT-SSCCH CS
  Phage_integrase 107 srqtvrkafkraveeagiekpltpHtlRhsfataLleagvdlrvvqkllGHssist 162
                      +  +++ ++++     g++ ++++H+lR s+at+L+ +gv+++v++ ++++   s 
       EFC35471.1  24 TPTQISNIISSSMSSIGVQ-NTSGHSLRISAATELASKGVSQSVIETAGNWVPNSK 78 
                      5567777778888888888.99****************************976665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (102 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.33s 00:00:00.73 Elapsed: 00:00:00.48
# Mc/sec: 635.35
//
Query:       EFC35472.1  [L=372]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.011   15.9   0.1      0.011   15.9   0.1    2.5  3  Fib_alpha  Fibrinogen alpha/beta chain family
      0.021   14.6   0.1      0.047   13.4   0.1    1.4  1  HGD-D      2-hydroxyglutaryl-CoA dehydratase, D-component
       0.18   11.8   2.5       0.49   10.5   1.3    2.3  2  Ins_beta   Nematode insulin-related peptide beta type


Domain annotation for each model (and alignments):
>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.9   0.1   1.9e-06     0.011      55     140 ..      98     183 ..      89     190 .. 0.81
   2 ?   -0.7   0.1      0.24   1.4e+03      64      94 ..     287     317 ..     279     330 .. 0.70
   3 ?   -3.2   0.0       1.4   8.4e+03      82      93 ..     346     357 ..     331     369 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.9e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSB-EE-- CS
   Fib_alpha  55 eelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesneqkiqkLeqdidqkerkCkepCkdsv 140
                 +++v ++ ++l+++  +k d ++vik++ske+ee+  r+   i++ +++  +L n+  + ++k+q L ++  q  ++ ++ C + +
  EFC35472.1  98 DSTVAAVIKKLEPTALEKLDPNHVIKNLSKEVEEKAPRIASIIVSSFRKALKLANTTTNSNEKLQALLKAYPQHLQNNHSLCDSGC 183
                 56666777777777777777799*******************************************99887777666555554444 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.24
                 HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH CS
   Fib_alpha  64 slrekqkskkdndnvikksskeleeeilrlk 94 
                  ++ +q + +++++++k+ + el++  l++k
  EFC35472.1 287 DTQYHQDKIRKQSKAYKERRVELRKTKLKFK 317
                 4455566666668888888888887777776 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 1.4
                 HHHHHHHCCCHH CS
   Fib_alpha  82 sskeleeeilrl 93 
                 +s+e+ + ++++
  EFC35472.1 346 YSSEVSKTVEKY 357
                 222222222232 PP

>> HGD-D  2-hydroxyglutaryl-CoA dehydratase, D-component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   7.9e-06     0.047      97     199 ..     122     226 ..     119     259 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 7.9e-06
                 HHHHHHHHHHHHT-..---HHHHHHHHHHHHHHHHHHHHHHHHTTSSS-SS-HHHHHHHHHHTT.S...-HHHHHHHHHHHHHHHHHHT.STS-EEE.. CS
       HGD-D  97 lenliaaleeitgk..rideesleaaikeanetrellkelytllpqspapihgfdllllakvvf.l...gkeeatealeelleeleerskseriRll.. 187
                 ++nl + +ee   +   i + s+++a+k+an t++  ++l  ll++   p h ++ + l+++ +     + + +t+   ++++e+++    +ri+    
  EFC35472.1 122 IKNLSKEVEEKAPRiaSIIVSSFRKALKLANTTTNSNEKLQALLKAY--PQHLQNNHSLCDSGCpHtikPEKLITKEEAQVVKEIFD----KRIKYShk 214
                 57888889999888777779************************666..9999999999999998789888888999999******9....33332222 PP

                 EEES---TT--H CS
       HGD-D 188 ltGipvellaak 199
                 ++ i++  ++++
  EFC35472.1 215 FCDIACNSQNNE 226
                 677766666655 PP

>> Ins_beta  Nematode insulin-related peptide beta type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   1.3   8.2e-05      0.49      10      47 ..     210     247 ..     207     248 .. 0.85
   2 ?   -1.0   0.0      0.31   1.9e+03       8      23 ..     350     364 ..     348     370 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 8.2e-05
                 HHHHHHTSSSS---S-TTHHHHHTTT---HHHHHHHH- CS
    Ins_beta  10 krVlalCGeecnvqndvdiatkCCkkeCtddyIksacC 47 
                 k+  + C  +cn+qn+++i +  C +     ++ ++ C
  EFC35472.1 210 KYSHKFCDIACNSQNNESIHSTICHTTPKTLDFSRNYC 247
                 666789*999**************99988788887777 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.31
                 HHHHHHHHTSSSS--- CS
    Ins_beta   8 LvkrVlalCGeecnvq 23 
                 ++k+V + C e  n  
  EFC35472.1 350 VSKTVEKYCAE-TNHH 364
                 679999***99.6655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (372 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1161  (0.0647554); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.46u 0.30s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 2475.79
//
Query:       EFC35473.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.019   14.7   8.4        0.3   10.8   3.2    2.1  2  Cytochrom_NNT  NapC/NirT cytochrome c family, N-terminal regi
       0.13   12.3   9.9        2.4    8.2   2.1    3.0  2  Cytochrome_C7  Cytochrome c7 and related cytochrome c
       0.49   11.0   0.2       0.49   11.0   0.2    3.1  2  zf-C2H2        Zinc finger, C2H2 type
       0.64   10.2  17.4        1.7    8.9   0.3    4.5  5  HNH            HNH endonuclease
        1.9    8.7   5.5         14    5.9   0.2    3.2  3  Zn-ribbon_8    Zinc ribbon domain


Domain annotation for each model (and alignments):
>> Cytochrom_NNT  NapC/NirT cytochrome c family, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.2    0.0012       4.3     115     163 ..      41      90 ..       7      94 .. 0.75
   2 ?   10.8   3.2   8.3e-05       0.3      72     145 ..     105     177 ..     102     189 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0012
  Cytochrom_NNT 115 rewarmkandsreCrnCHseeamdlekqkkkaakahkkaaeeek.tCidC 163
                    + w + +++ +  Cr CH  e+    +  ++ +  h+k+++    +C +C
     EFC35473.1  41 ADWFKKNEKLEVLCRPCHGLEHARNVEGGSNWQYCHEKMINLMGgKCKEC 90 
                    5566666777788********99988999999999999996433388888 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 8.3e-05
  Cytochrom_NNT  72 HvPkelvkklarkiqaskevlaklvgkidtkekfeakrlelaerewarmka..ndsreCrnCHseeamdlekqkkk 145
                    Hv +++ + +++++qa++++  +  +    ++++++ +l la +e +++++  + +  C  CH +e+m+ +++++ 
     EFC35473.1 105 HVHHKNRDGVKKRAQATEDIDDEEREV---AQHVNEYKLILAMTEEQQVEKlkEFELLCDGCHYFEHMEKHARSEV 177
                    99999999***********99988444...4555555566666555555550045677**********99888765 PP

>> Cytochrome_C7  Cytochrome c7 and related cytochrome c
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   2.1   0.00067       2.4      40      73 .]      44      77 ..      18      91 .. 0.73
   2 ?    1.8   6.8     0.068   2.4e+02      33      61 ..     143     171 ..      76     186 .. 0.64

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00067
  Cytochrome_C7 40 skkaeveslt..CgaCHdgknafsvakkaeCakCHt 73
                    kk+e    +  C  CH  ++a +v++  + + CH+
     EFC35473.1 44 FKKNEKL--EvlCRPCHGLEHARNVEGGSNWQYCHE 77
                   3223333..255999999999998888888888885 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.068
  Cytochrome_C7  33 aemekgkskkaeveslt.....CgaCHdgknafs 61 
                    a++e+++++k      +     C+ CH  +++++
     EFC35473.1 143 AMTEEQQVEKL-----KefellCDGCHYFEHMEK 171
                    33333344333.....044455999998777764 PP

>> zf-C2H2  Zinc finger, C2H2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.2   0.00014      0.49       2      16 ..      86     100 ..      86     102 .. 0.93
   2 ?   -1.5   1.8       1.3   4.6e+03      16      23 .]     165     172 ..     163     175 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00014
                 EETTTTEEESSHHHH CS
     zf-C2H2   2 kCpdCgksFkrksnL 16 
                 kC++Cg sF ++s+L
  EFC35473.1  86 KCKECGLSFESNSEL 100
                 7************98 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.3
                 HHHHHHCC CS
     zf-C2H2  16 LkrHirtH 23 
                 +  H+ +H
  EFC35473.1 165 YFEHMEKH 172
                 56677776 PP

>> HNH  HNH endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.2     0.048   1.7e+02       8      25 ..       4      21 ..       1      27 [. 0.75
   2 ?    7.4   0.4    0.0013       4.8      33      47 .]      50      64 ..      45      64 .. 0.88
   3 ?   -3.5   0.2       3.6   1.3e+04      39      42 ..      74      77 ..      73      78 .. 0.50
   4 ?    8.9   0.3   0.00048       1.7       1      19 [.      87     109 ..      87     125 .. 0.85
   5 ?    2.2   0.1     0.059   2.1e+02      34      43 ..     157     166 ..     134     170 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.048
         HNH  8 fhksealevdHiipisqg 25
                 h ++a++ +H+  +++ 
  EFC35473.1  4 LHEVNAFTLHHVMYKDDD 21
                455589******998875 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0013
         HNH 33 lqllCksCHnkkhdr 47
                l+ lC+ CH  +h+r
  EFC35473.1 50 LEVLCRPCHGLEHAR 64
                889********9986 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 3.6
         HNH 39 sCHn 42
                 CH 
  EFC35473.1 74 YCHE 77
                4664 PP

  == domain 4  score: 8.9 bits;  conditional E-value: 0.00048
         HNH   1 CeyCgrkfhks....ealevdHi 19 
                 C +Cg  f+ +    + ++v+H+
  EFC35473.1  87 CKECGLSFESNselgKIFHVHHK 109
                 ***********988888888885 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.059
         HNH  34 qllCksCHnk 43 
                 +llC  CH  
  EFC35473.1 157 ELLCDGCHYF 166
                 79******65 PP

>> Zn-ribbon_8  Zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.18   6.4e+02      24      37 ..      48      63 ..      41      66 .. 0.69
   2 ?    5.9   0.2     0.004        14       7      17 ..      86      96 ..      86     111 .. 0.79
   3 ?    2.8   0.3     0.037   1.3e+02       4      21 ..     156     172 ..     155     178 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.18
  Zn-ribbon_8 24 aplta.CPeCgs.evr 37
                 ++l++ C  C++ e  
   EFC35473.1 48 EKLEVlCRPCHGlEHA 63
                 4566679999987654 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.004
  Zn-ribbon_8  7 rCeeCghefev 17
                 +C+eCg  fe 
   EFC35473.1 86 KCKECGLSFES 96
                 7********93 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.037
  Zn-ribbon_8   4 YeYrCeeCghefevlqsi 21 
                  +e  C+ C+  fe++ + 
   EFC35473.1 156 FELLCDGCH-YFEHMEKH 172
                  4566****9.***99864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1248  (0.0696079); expected 358.6 (0.02)
Passed bias filter:                      574  (0.0320152); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1231.94
//
Query:       EFC35474.1  [L=337]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.9e-06   26.2   5.1    6.1e-06   25.6   1.6    2.6  3  NRDE-2       NRDE-2, necessary for RNA interference
    0.00072   19.6   9.0      0.002   18.1   9.0    1.8  1  Suf          Suppressor of forked protein (Suf)
  ------ inclusion threshold ------
      0.057   13.3   0.3        3.9    7.4   0.1    3.7  3  TPR_1        Tetratricopeptide repeat
      0.087   13.7   0.0         59    4.9   0.0    3.5  3  TPR_14       Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> NRDE-2  NRDE-2, necessary for RNA interference
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.1   0.00052       2.3      44     109 ..      20      82 ..       1      89 [. 0.69
   2 !   25.6   1.6   1.4e-09   6.1e-06      10     133 ..      34     179 ..      26     186 .. 0.85
   3 ?   -2.3   0.1       0.4   1.8e+03     202     211 ..     258     267 ..     237     328 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00052
      NRDE-2  44 kalaeiklsilekAleknksnpdserLllelLklgseiwdseklakeWeellkenpnsvkLWreyl 109
                  ++ +  ++ +e  l +n   p++     +++k  + + +s+k+ k +e++l++ p  ++ W++y 
  EFC35474.1  20 LKTPQDYIKEYELILLNN---PNDYYTWEKYIKVLEIEESSDKVLKGYEKFLEQFPLLFGYWKKYA 82 
                 445555555555555555...666666678999999999999999999999999999999999996 PP

  == domain 2  score: 25.6 bits;  conditional E-value: 1.4e-09
      NRDE-2  10 veenPedidaWlelvefQdellsaeee......................slskserkalaeiklsilekAleknksnpdserLllel.Lklgseiwdse 85 
                 + +nP+d  +W +++++ + + + +++                      ++ + +  + +e+ ++++ek++ k+++  ++ +L  ++ L  +++  d +
  EFC35474.1  34 LLNNPNDYYTWEKYIKVLE-IEESSDKvlkgyekfleqfpllfgywkkyATLTYQVTQSYEKTIQVYEKSVDKKTGIFNNPDLWANYcLFVAEQSPDVN 131
                 5689***********9998.33333336777888999999999999999777778999*************************998746777778999* PP

      NRDE-2  86 klakeWeellk...enpnsvkLWreyldfrqsnfasfsvekvkelyekclr 133
                 ++++ +e++++   +     +LW++y++f++s   + ++ekv +ly+++++
  EFC35474.1 132 EIRNLFEKAIQiigNDYYARTLWENYIEFEIS---QDEYEKVVKLYKRAIQ 179
                 ***********9865558899*********99...789**********998 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 0.4
      NRDE-2 202 lkeFeeFWes 211
                 l+++ ++W  
  EFC35474.1 258 LNDLTSYWRE 267
                 5555555543 PP

>> Suf  Suppressor of forked protein (Suf)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   9.0   4.6e-07     0.002      43     136 ..      83     180 ..      77     333 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 4.6e-07
         Suf  43 llEyyiskdkkvAtkIFelGlKk...FpedeefvlkYldyLisl.nddnnaRvlfekvvsklskekeakelykkfleyestfgdlssilklekRmeel 136
                 +l y++++  +  ++++e  + k     ++++  ++Y  +  +   d+n++R lfek+++ + ++  a+ l++ ++e+e  + + ++++kl kR  ++
  EFC35474.1  83 TLTYQVTQSYEKTIQVYEKSVDKktgIFNNPDLWANYCLFVAEQsPDVNEIRNLFEKAIQIIGNDYYARTLWENYIEFEISQDEYEKVVKLYKRAIQV 180
                 555666666555666666554221222245566666777776541599**********************************************8776 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.16     7e+02      11      27 ..      86     102 ..      84     105 .. 0.73
   2 ?   -0.5   0.0      0.28   1.3e+03      24      30 ..     137     143 ..     135     147 .. 0.77
   3 ?    7.4   0.1   0.00088       3.9      13      29 ..     163     179 ..     162     180 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.16
                 HHHTT-HHHHHHHHHHH CS
       TPR_1  11 yfklgkydeAleyyekA 27 
                 y+  + y++ ++ yek 
  EFC35474.1  86 YQVTQSYEKTIQVYEKS 102
                 55566789999999886 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.28
                 HHHHHHH CS
       TPR_1  24 yekALel 30 
                 +ekA+++
  EFC35474.1 137 FEKAIQI 143
                 8999998 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.00088
                 HTT-HHHHHHHHHHHHH CS
       TPR_1  13 klgkydeAleyyekALe 29 
                 ++ +y++ ++ y++A++
  EFC35474.1 163 SQDEYEKVVKLYKRAIQ 179
                 5899************8 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.051   2.3e+02       4      43 ..      44      83 ..      23      84 .. 0.91
   2 ?    1.7   0.0      0.13     6e+02      10      38 ..     123     151 ..     113     156 .. 0.73
   3 ?    4.9   0.0     0.013        59       4      29 ..     154     179 ..     151     186 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.051
      TPR_14  4 llalaeallalGdpdeAiallrralalaPddaeawlllaq 43
                + ++ ++l+  +  d+ ++ +++ l+++P    +w  +a 
  EFC35474.1 44 WEKYIKVLEIEESSDKVLKGYEKFLEQFPLLFGYWKKYAT 83
                66789999999999999999*********99999999886 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.13
      TPR_14  10 allalGdpdeAiallrralalaPddaeaw 38 
                 + +++ d  e ++l+++a++   +d  a+
  EFC35474.1 123 VAEQSPDVNEIRNLFEKAIQIIGNDYYAR 151
                 67889999999*******99866666555 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.013
      TPR_14   4 llalaeallalGdpdeAiallrrala 29 
                 +  + e++  ++++++ ++l++ra++
  EFC35474.1 154 WENYIEFEISQDEYEKVVKLYKRAIQ 179
                 5568899999**************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (337 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1930  (0.107647); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 2051.25
//
Query:       EFC35475.1  [L=225]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      8e-40  136.7   0.1    1.3e-39  136.0   0.1    1.3  1  Ku        Ku70/Ku80 beta-barrel domain
  ------ inclusion threshold ------
       0.61   10.1   6.7        2.6    8.1   6.7    2.2  1  DUF3926   Protein of unknown function (DUF3926)


Domain annotation for each model (and alignments):
>> Ku  Ku70/Ku80 beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  136.0   0.1   1.5e-43   1.3e-39      18     178 ..       2     218 ..       1     223 [. 0.88

  Alignments for each domain:
  == domain 1  score: 136.0 bits;  conditional E-value: 1.5e-43
          Ku  18 akkpkfkkldketnepvkvetkyvcsdtge.vdee..........................................divkgyeyGgevvpltkeelek 73 
                 ++kp  + l+++tn+ +k etk++c+dtg+ + ++                                          d++ +yeyGg +  +t eel++
  EFC35475.1   2 TRKPAAVHLHSDTNKLLKCETKFICQDTGTeLMRNgnnilqnelssstttttttnnnnnttssstneftnssssssnDMIYYYEYGGHKSEFTLEELTN 100
                 57899***********************8444444555555556666777777777888888888888888899999*********************8 PP

          Ku  74 iks.fd.........skglkllgFvplseilkeylsikssyfiyPddkdekgstkafsaLveamleskkvaivrfvlrskskprlvaLvPqeeelssee 162
                 ik+  +         ++g+kl+gF+p+s+ lk+y++ kss f+yP+d++++gs  ++saL+++m+e++++ai+rf+ r+ + p+++aL+Pqee +++e+
  EFC35475.1 101 IKQlKNvsgvknehvQPGIKLIGFKPKSR-LKIYHNYKSSGFLYPNDSKINGSLLTLSALHKKMIEMNRIAICRFIQREGTMPQFIALLPQEELIDEES 198
                 888444888999999************99.*************************************************************99999887 PP

          Ku 163 e....keglvlvtLpfaddi 178
                 +    ++g+ +++Lp+ad+ 
  EFC35475.1 199 NtqitPPGFQIIYLPYADEY 218
                 7***777***********96 PP

>> DUF3926  Protein of unknown function (DUF3926)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   6.7   0.00029       2.6      20      41 ..      39      58 ..      34      75 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00029
     DUF3926 20 NILQEELSSymqEttHstksNL 41
                NILQ ELSS    tt   ++N 
  EFC35475.1 39 NILQNELSSSTTTTTT--TNNN 58
                9********9876664..4553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1388  (0.0774165); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 1475.36
//
Query:       EFC35476.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.016   15.0   0.2      0.037   13.9   0.2    1.6  1  F-box      F-box domain
      0.027   14.1   0.0      0.063   12.9   0.0    1.6  2  Ras        Ras family
      0.074   13.6   0.2       0.52   10.9   0.0    2.1  2  AAA_18     AAA domain
      0.074   12.8   0.0       0.18   11.5   0.0    1.6  2  AAA_24     AAA domain
       0.17   11.1   0.3       0.81    8.9   0.2    1.9  2  Herpes_TK  Thymidine kinase from herpesvirus


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.2     1e-05     0.037       1      47 [.       1      47 [.       1      48 [. 0.92

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1e-05
                -HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHHHH CS
       F-box  1 ftlsrLPsevlrhILerLplsdllalrrVSkgwrilidsdrlwcksi 47
                ++l   P++ +  I ++L++s+ l l++  + w  l++sd+ w+ +i
  EFC35476.1  1 MSLQLIPLDTITIIAKFLSFSEHLQLMLINTIWFHLLNSDEMWRGRI 47
                577889***********************************998766 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.1   3.9e+03      70      91 ..      86     107 ..      73     123 .. 0.54
   2 ?   12.9   0.0   1.8e-05     0.063       2      60 ..     144     205 .]     143     205 .] 0.77

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.1
                 TTESEEEEEEETTBHHHHHTHH CS
         Ras  70 rdaegillvyditsresfenvk 91 
                 ++ e i l y +++ +  +++k
  EFC35476.1  86 ETKESIDLAYKLKECKKIKKLK 107
                 3334444555555555555555 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 1.8e-05
                 EEEEESTTSSHHHHHHH.HHHSSCSSSCTTTSSEE.EEEEEEEET.TEEEEEEEEEETTSGG CS
         Ras   2 lvlvGdsavGKtslllr.fvkdkFkeeyesTigvd.fytkeievd.gkevkleiwDTAGqee 60 
                 + lvG  a+GKt+l +  + +++ ++  e   g    y  ++++d ++ + l++ DT Gqee
  EFC35476.1 144 CCLVGPHAIGKTTLCYYlHLRNEKSKLEEWFSGWGpHYYDSCDIDrSEGYCLQLVDTPGQEE 205
                 679***********865256666665555555554488899999977889**********97 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.4      0.26   9.4e+02      16      68 ..      59     118 ..      38     138 .. 0.65
   2 ?   10.9   0.0   0.00015      0.52       2      22 ..     145     165 ..     144     196 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.26
      AAA_18  16 keLskrlgf.....gvnlrdvakenglllevdpe...aldeskrldedkldklldaleens 68 
                 k L++++ +     + n+r+++ + + ++ +  +   +l+e+k++++ k + ++++ ee+ 
  EFC35476.1  59 KLLNREEPIklhaeSSNIREILMNIYKETKESIDlayKLKECKKIKKLK-NTWSTNSEEIE 118
                 4454444445555666666666665555555555777777777777666.66666666654 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00015
      AAA_18   2 lltGtpGvGKttlakeLskrl 22 
                 +l G+++ GKttl+ +L  r+
  EFC35476.1 145 CLVGPHAIGKTTLCYYLHLRN 165
                 799**************4443 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.2   4.4e+03     177     190 ..      98     111 ..      79     123 .. 0.56
   2 ?   11.5   0.0   4.9e-05      0.18       2      22 ..     141     161 ..     140     171 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.2
      AAA_24 177 kvgervlktskses 190
                 k+++++ k+++++s
  EFC35476.1  98 KECKKIKKLKNTWS 111
                 44555555555544 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 4.9e-05
      AAA_24   2 klkiliyGpsgiGKTtlakel 22 
                 +++++++Gp  iGKTtl++ l
  EFC35476.1 141 PIRCCLVGPHAIGKTTLCYYL 161
                 579**************9877 PP

>> Herpes_TK  Thymidine kinase from herpesvirus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.2   0.00023      0.81     184     246 ..      22      87 ..      12     119 .. 0.85
   2 ?    0.1   0.0      0.11   3.9e+02       1      12 [.     148     159 ..     148     183 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00023
                 HHHHHHHHHHHHH..HHTT--HHHHGGGG...TS-----------SSSS.S---GGGSGGGGGG-G CS
   Herpes_TK 184 rnvyillvntvay..lkskdkweadweaLeffegslaetlikepeikar.erpsiedtLfavlklp 246
                  +   +l+nt+ +  l+s + w+    +L+      a+ l++e+ ik+  e  +i + L+ + k  
  EFC35476.1  22 EHLQLMLINTIWFhlLNSDEMWRGRITQLDSHLSIHAKLLNREEPIKLHaESSNIREILMNIYKET 87 
                 556679*****985567999*********988888888888899999887999*******999864 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.11
                 SSTTSSHHHHH. CS
   Herpes_TK   1 GafGiGkttvle 12 
                 G++ iGktt   
  EFC35476.1 148 GPHAIGKTTLCY 159
                 89******9874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1295  (0.0722293); expected 358.6 (0.02)
Passed bias filter:                      674  (0.0375927); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1256.07
//
Query:       EFC35477.1  [L=134]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.6e-11   41.3   6.4    1.6e-06   27.7   0.7    2.5  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    5.5e-05   23.7   1.8       0.21   12.2   0.0    3.1  3  RCC1      Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.7   1.8e-10   1.6e-06       1      29 [.       7      35 ..       7      36 .. 0.93
   2 !   16.7   0.1   5.1e-07    0.0046      11      30 .]      68      87 ..      64      87 .. 0.93
   3 ?   -2.7   0.0      0.64   5.7e+03       6      13 ..     120     127 ..     118     132 .. 0.68

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 1.8e-10
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29
                V ++ +G+   +a+t+ +eV+cWG+N++G
  EFC35477.1  7 VSKIFCGSLSGIAITSQDEVYCWGDNGSG 35
                668999*********************99 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 5.1e-07
      RCC1_2 11 scaLtedGeVlcWGsNsdGQ 30
                +++Lt++G Vl +G+Ns+ Q
  EFC35477.1 68 TIILTRSGQVLICGNNSNNQ 87
                789**************998 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 0.64
      RCC1_2   6 aGdyHsca 13 
                  G  H ++
  EFC35477.1 120 GGFQHMIV 127
                 58899887 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.05   4.5e+02      36      44 ..       6      14 ..       1      20 [. 0.81
   2 !    8.3   0.1    0.0004       3.6       2      20 ..      24      42 ..      23      51 .. 0.81
   3 !   12.2   0.0   2.4e-05      0.21       1      17 [.      74      90 ..      74     125 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.05
                -EEEEEEET CS
        RCC1 36 rvvkvacGd 44
                +v+k++cG+
  EFC35477.1  6 PVSKIFCGS 14
                89******7 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0004
                TEEEEEE--GGGTTSSSS- CS
        RCC1  2 GrVysWGrndyGqLGlgtt 20
                ++Vy+WG n  G  G++++
  EFC35477.1 24 DEVYCWGDNGSGETGIPSS 42
                58********999888776 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 2.4e-05
                TTEEEEEE--GGGTTSS CS
        RCC1  1 dGrVysWGrndyGqLGl 17
                +G+V+ +G+n+++qLG 
  EFC35477.1 74 SGQVLICGNNSNNQLGA 90
                69**************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (134 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       356  (0.0198561); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.44
# Mc/sec: 922.93
//
Query:       EFC35478.1  [L=117]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-11   43.9   0.1    2.4e-11   43.4   0.1    1.3  1  DUF4246   Protein of unknown function (DUF4246)


Domain annotation for each model (and alignments):
>> DUF4246  Protein of unknown function (DUF4246)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.4   0.1   1.4e-15   2.4e-11     401     448 ..       5      52 ..       1      57 [. 0.95

  Alignments for each domain:
  == domain 1  score: 43.4 bits;  conditional E-value: 1.4e-15
     DUF4246 401 pNvlqhrvepfeLaDktkpGhrkilaLfLVDPhiriistanVppQqkd 448
                 pN+ qhrv++f  +D+t    rkil++f VDP+ +i+st+n+  Q++d
  EFC35478.1   5 PNTHQHRVRHFFPKDPTEVATRKILVFFFVDPEKPIVSTSNIDNQRRD 52 
                 9*********************************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (117 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       691  (0.0385409); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.49
# Mc/sec: 721.55
//
Query:       EFC35479.1  [L=244]
Description: hypothetical protein NAEGRDRAFT_54894 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-90  303.4   0.1      1e-89  301.0   0.1    1.8  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  301.0   0.1   5.8e-94     1e-89     126     407 .]       1     244 []       1     244 [] 0.97

  Alignments for each domain:
  == domain 1  score: 301.0 bits;  conditional E-value: 5.8e-94
       Actin 126 lylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtprylikkkkvveaessaekeelekltesy 224
                 +y+a +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G++Lt++l+++l ++                              ++s+
  EFC35479.1   1 MYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMER------------------------------GYSF 69 
                 5899************************************************************8..............................9*** PP

       Actin 225 ktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleeekskllgiselivaainacdvdlr 321
                 +t++e+e++++iKe++c+v+ d+e+  +++++sss+++sYeLPDg+ i++g+eRf++pE+LF+p+ ig+e a         g++e ++++i +cd+d+r
  EFC35479.1  70 NTSAEREIVRDIKEKLCYVAFDFETemKKASDSSSIDTSYELPDGNIITVGNERFRCPEVLFQPNFIGMEAA---------GVHETTFNSIGKCDIDIR 159
                 ***********************98555566669************************************99.........****************** PP

       Actin 322 peLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGssvverkck 407
                 ++L+an+v++GG+++++g+ eR++kel+++a++++k+k++ap+ erkys+WiGGSiL+sl+tfq++w++ +EYe+ G  +v+rkc+
  EFC35479.1 160 KDLYANVVLSGGTTMFEGIAERMNKELTAMAPASMKIKVVAPP-ERKYSVWIGGSILSSLSTFQSMWITAEEYEDAGCAIVHRKCF 244
                 *******************************************.*****************************************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       417  (0.0232584); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1595.25
//
Query:       EFC35480.1  [L=104]
Description: cytochrome b5 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-15   56.3   0.1    3.1e-15   56.1   0.1    1.1  1  Cyt-b5    Cytochrome b5-like Heme/Steroid binding domain


Domain annotation for each model (and alignments):
>> Cyt-b5  Cytochrome b5-like Heme/Steroid binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.1   0.1   1.7e-19   3.1e-15       2      72 ..       7      77 ..       6      79 .. 0.90

  Alignments for each domain:
  == domain 1  score: 56.1 bits;  conditional E-value: 1.7e-19
                HHHHTTTE.CTTEEEEEETTEEEECTTTCCCSTTCSHHHHTTTTSBBHHHHHHTTGGCHHHHHHHHGGEEEE CS
      Cyt-b5  2 leelskhn.gkndlwvairgkVYDvskflskhpGgesailkyaGkDateafksvvhsekdaekllkkylvGk 72
                l+e+++h  +++d w++i gkV  +  + ++hpGge++il+ aGkD t+af++  h +++ +  ++ky vG+
  EFC35480.1  7 LSEVEEHGpNHQDPWIIISGKVVAFGTYKDEHPGGEDVILEWAGKDGTKAFNDAGHGSSA-KSDMQKYIVGE 77
                589****96666******************************************998885.555599****8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (104 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       303  (0.0169); expected 358.6 (0.02)
Passed bias filter:                      245  (0.013665); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.39u 0.27s 00:00:00.66 Elapsed: 00:00:00.43
# Mc/sec: 727.63
//
Query:       EFC35481.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1761.39
//
Query:       EFC35482.1  [L=234]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (234 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1617  (0.0901891); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1475.10
//
Query:       EFC35483.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.8e-31  108.0   0.1    7.8e-31  107.9   0.1    1.1  1  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.9   0.1   4.3e-35   7.8e-31      83     208 ..       7     155 ..       1     156 [. 0.85

  Alignments for each domain:
  == domain 1  score: 107.9 bits;  conditional E-value: 4.3e-35
      DUF563  83 allpklrdrlrerlnlekr..kkp...trvlyisR.........lkagsRrilNeeevl.......kllpkrgfevvdpeslsfeeqiklfssakvivg 160
                 +l  ++++r+++ l+++kr  + +   +rvl+isR         ++  sR+i+Neeevl       ++ +k+++e+vd+++l + eqi+ ++++++++g
  EFC35483.1   7 PLVANFANRILNGLGIKKReiN-KgdvIRVLFISRrpyvkfgveHNFMSRQISNEEEVLdrmkthrEYGKKFTVERVDFAHLKLVEQIQKVHDSDFLIG 104
                 55569*************9862.34699*******8776666655555**********988866655555666************************** PP

      DUF563 161 phGsgltnliFmpp.gttvielvppnrldns..fenlaallglkyayvlge 208
                 +hG+glt++++mp+  ++v+e++++ + + +  fe+++ ++g++y+++ ++
  EFC35483.1 105 YHGAGLTHSLWMPEeTSAVLEIWNTVTTRGWrcFEQFTFWKGNDYTLWSNS 155
                 ************7747******99977777788***************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 1128.75
//
Query:       EFC35484.1  [L=628]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.2e-25   87.6   4.2    1.7e-07   30.9   0.0    6.6  6  DUF4116     Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.031   15.1   0.7      0.057   14.3   0.7    1.4  1  Stm1_N      Stm1


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.3e-07     0.003       1      41 [.     325     365 ..     325     372 .. 0.92
   2 !   18.4   0.0   1.5e-07    0.0013       2      47 ..     375     420 ..     374     422 .. 0.95
   3 ?   -1.5   0.0      0.23   2.1e+03       2      16 ..     469     486 ..     469     497 .. 0.66
   4 ?   -1.3   0.0      0.21   1.9e+03       6      21 ..     526     541 ..     525     542 .. 0.61
   5 !   30.9   0.0   1.8e-11   1.7e-07       2      44 ..     546     587 ..     545     591 .. 0.95
   6 !   15.6   0.1   1.1e-06    0.0095       3      33 ..     598     628 .]     597     628 .] 0.95

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.3e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 D E++l++++ +g  + ++s +L+n+  + ++Av+qng  +
  EFC35484.1 325 DMEVMLKYIDFHGDFYLKASQRLQNHHKVRKRAVQQNGMLI 365
                 77************************************654 PP

  == domain 2  score: 18.4 bits;  conditional E-value: 1.5e-07
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 ++++leavk +g+a++ + ++ + D  i  +Avk+ng al+y+  e
  EFC35484.1 375 KDLILEAVKEDGMAITVFENNGCWDTVITTEAVKSNGMALEYLGSE 420
                 89****************************************9766 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.23
     DUF4116   2 rEivleavkkngs...al 16 
                 +Ei  e++k +++   +l
  EFC35484.1 469 KEILVEVMKVHPYsqyYL 486
                 577777777777744444 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.21
     DUF4116   6 leavkkngsalkylse 21 
                  ++++ +g+al  +++
  EFC35484.1 526 EKLIEYDGNALCLIND 541
                 4667777777766665 PP

  == domain 5  score: 30.9 bits;  conditional E-value: 1.8e-11
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 rE++l+av++ng++l+y++ +L  D ei+ +A+++n+ a+ ya
  EFC35484.1 546 REMILQAVQNNGESLEYANIDLV-DDEIIAEAIRNNPEAIQYA 587
                 9********************97.****************998 PP

  == domain 6  score: 15.6 bits;  conditional E-value: 1.1e-06
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkA 33 
                  ++l++ k ng+++ y   e++nD++++l+A
  EFC35484.1 598 SFILNLAKENGEIICYTHREIRNDRDVLLAA 628
                 59**************************997 PP

>> Stm1_N  Stm1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.7   6.4e-06     0.057       5      38 ..       3      36 ..       1      52 [. 0.77

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 6.4e-06
      Stm1_N  5 NlFDLLGdDdeeDpsqaapapppkevdkkstrsa 38
                NlFDLL +++++  +q+ p++  k ++kk+ +s+
  EFC35484.1  3 NLFDLLDEEENDQQEQQIPKKLSKRAQKKALKST 36
                *********8888888777777777777765544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (628 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1598  (0.0891293); expected 358.6 (0.02)
Passed bias filter:                      543  (0.0302861); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.82u 0.37s 00:00:01.19 Elapsed: 00:00:00.58
# Mc/sec: 3246.15
//
Query:       EFC35485.1  [L=286]
Description: rasGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-34  120.2   4.8    1.9e-34  119.4   4.8    1.4  1  RasGEF    RasGEF domain


Domain annotation for each model (and alignments):
>> RasGEF  RasGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  119.4   4.8     1e-38   1.9e-34       1     176 [.      74     249 ..      74     250 .. 0.90

  Alignments for each domain:
  == domain 1  score: 119.4 bits;  conditional E-value: 1e-38
      RasGEF   1 elAeqltlieaelfskikpeellgsawsked...rspnveaviarfnrlsnwvaseilseeslkkRakviekfikiakecrklnNfnslmailsaLqss 96 
                 e+A+qltl+e++lf +i  eel++  w++ +   r+pn+++++ +f ++++w++ +i++ +      + i++ i i+++++klnNfn+l ail a++  
  EFC35485.1  74 EIARQLTLYEYDLFVAIGLEELMSFGWKRLKfkhRCPNINKLLIHFENVTKWISFSICKPK----SKNPIKRCISICEHLKKLNNFNTLKAILNAFEYG 168
                 79*************************998887566**********************654....5678****************************** PP

      RasGEF  97 pvsrLkktweavskkslktleeleelmspennfknyrealkssa.sskpciPflglyltdltfieegnpdtl....egk.iNfeKr 176
                 +v+ Lk   ++   +++    ++++lms+e+n+++yr++lk+s+ +++++iP++ l+l+dl  +ee+ +d++    + + iN+ Kr
  EFC35485.1 169 EVKTLKINQSEQA-NKM----KFQQLMSEESNYQEYRQTLKESSeENTSIIPYVRLHLRDLFLVEENQNDFVigpnSIEfINWMKR 249
                 *****98877665.334....59******************9996677788**********99**9999999999866779*9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1338  (0.0746277); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 1628.98
//
Query:       EFC35486.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.4    8.4   9.7       0.12   12.6   3.0    2.3  3  PAC4      Proteasome assembly chaperone 4


Domain annotation for each model (and alignments):
>> PAC4  Proteasome assembly chaperone 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.2       0.4   7.2e+03      44      65 ..      25      44 ..      15      45 .. 0.43
   2 ?   -1.2   0.2      0.14   2.5e+03      27      52 ..      86     113 ..      73     124 .. 0.54
   3 ?   12.6   3.0   6.6e-06      0.12      18      64 ..     122     166 ..     105     167 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.4
        PAC4 44 ptisTtLlgdgsdeaserlAqr 65
                p is++  ++++ + +++l+++
  EFC35486.1 25 P-ISSSSSNTNT-NSTSSLSKI 44
                4.3443333333.345566665 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.14
        PAC4  27 plgslvvAmpsrtn.kktpti..sTtLlg 52 
                  +++l++  +s+   +++p +  +++L++
  EFC35486.1  86 IMNNLHLTPKSQSLtQSNP-LstTSSLFT 113
                 4666666655555533334.412334554 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 6.6e-06
        PAC4  18 gtasskeasplgslvvAmpsrtnkktptisTtLlgdg.sdeaserlAq 64 
                 +++ss +++++gs+ +A p+r +   +t+s+++++ + s++ s+++A+
  EFC35486.1 122 NNTSSSSKNQFGSWLLATPRRSQ---STTSSPIINNSvSNQSSSSVAS 166
                 44444444489**********99...579******9999999999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2108  (0.117575); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.38s 00:00:01.12 Elapsed: 00:00:00.54
# Mc/sec: 1771.07
//
Query:       EFC35487.1  [L=450]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-26   93.2   0.0    4.8e-26   91.5   0.0    1.7  2  FAD_binding_5  FAD binding domain in molybdopterin dehydrogen
    1.4e-14   54.4   0.0    3.7e-14   53.0   0.0    1.8  1  Ald_Xan_dh_C   Aldehyde oxidase and xanthine dehydrogenase, a
    1.7e-10   41.0   0.0    1.3e-09   38.1   0.0    2.2  1  CO_deh_flav_C  CO dehydrogenase flavoprotein C-terminal domai


Domain annotation for each model (and alignments):
>> FAD_binding_5  FAD binding domain in molybdopterin dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.5   0.0   8.1e-30   4.8e-26      59     170 ..      95     216 ..      86     217 .. 0.94
   2 ?   -1.9   0.0      0.41   2.5e+03      22      53 ..     294     325 ..     289     330 .. 0.77

  Alignments for each domain:
  == domain 1  score: 91.5 bits;  conditional E-value: 8.1e-30
                    EEEESSEEEEETTSBHHHHHHHHHHHHHHHHSH...........HHHHTSS-HHHHHH-BHHHHHHHT-TT-SSHHHHHHTTEEEEEEESSE.EEE CS
  FAD_binding_5  59 ieeteggleiGAavtlselaaealvrerypals...........ealekiAspqiRnvaTiGGNlataspisDlapaLlaldAevelrsaeg.ere 142
                    ++ + ++l iG+ +t+s+l  e++++++++ l+           ++ + +As+ iRn+a+++GN++tasp+sDl+p+++ald+++++++ +g  ++
     EFC35487.1  95 LNLNIKSLIIGSSITISNL--EEFIKKQIKILPkyqsqslecilHQTKYFASTPIRNAACLAGNIITASPASDLNPLWVALDCNLKIMQMDGhVKT 188
                    4556689************..9**********************************************************************99** PP

                    EECHHHEEETTEESS-TT-EEEEEEEE- CS
  FAD_binding_5 143 vpleeflkgpgktalepgelitaveiPa 170
                    +p++ef++g+++ +l+++el+ ++eiP 
     EFC35487.1 189 IPFKEFFTGYRQVQLKKSELLIHLEIPL 216
                    ***************************7 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.41
                    TTSEEESS-TTHHHHHHHTT---SEEEEGTTS CS
  FAD_binding_5  22 pdaklvaGgtdlgvlmkekvarpehliditgi 53 
                    +d+klv Gg +  +   ek +++   ++i+++
     EFC35487.1 294 QDIKLVYGGMNAYTVSAEKTRQYLIELKIREL 325
                    57899****99999999999877555555554 PP

>> Ald_Xan_dh_C  Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.0   0.0   6.2e-18   3.7e-14       1      74 [.     374     446 ..     374     450 .] 0.88

  Alignments for each domain:
  == domain 1  score: 53.0 bits;  conditional E-value: 6.2e-18
                   TT-SCCGGGCC.-TTTEEEEEEE-SSSSEEEEEEE-HHHHCSTTEEEEEEHHHHCCGTECCTTSSS-EEEESS-S CS
  Ald_Xan_dh_C   1 tGeavYvdDip.apgalylafvrStkahAkivsidvsaalalpGVvavitakdlpkenkaigsiledeedallae 74 
                   tGea+YvdDi+ ++g+ly+a+v S+k+ A i+si +++al+++GV+ ++++ d++++n+ ++ i++dee  l+++
    EFC35487.1 374 TGEAKYVDDIQpIYGQLYAALVQSSKPLALIKSISYDKALSMKGVIGYVDYRDVKGHNRVGAVIPDDEE--LFIS 446
                   8********96277788****************************************999987776664..7765 PP

>> CO_deh_flav_C  CO dehydrogenase flavoprotein C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.1   0.0   2.2e-13   1.3e-09       2      61 ..     231     324 ..     230     350 .. 0.92

  Alignments for each domain:
  == domain 1  score: 38.1 bits;  conditional E-value: 2.2e-13
                    EEEEESSSSSS-ESEEEEEEEEEET.................................TC.EECEEEEEEESSSSS-EE-HHHHHHHTTSBSSH CS
  CO_deh_flav_C   2 ayklsrrrendiaivnaAfrvelee.................................dg.kiedariafggvaptpvraekaeaaLiGkplse 61 
                    ++k+s+rre+diaiv+ A+ ++l +                                 ++  i+d+++++gg+++ +v+aek+ ++Li+ ++ e
     EFC35487.1 231 SFKQSKRREDDIAIVTSAMKIKLFKnnnlnninnnnlnninnnnsnsnnnninnnninNKyYIQDIKLVYGGMNAYTVSAEKTRQYLIELKIRE 324
                    8**********************99999**************************9996448***************************987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (450 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1330  (0.0741815); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 2540.60
//
Query:       EFC35488.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.012   15.8   0.1      0.024   14.8   0.1    1.5  1  PP-binding_2     Acyl-carrier
      0.032   14.1  19.2      0.038   13.8  19.2    1.1  1  ERM              Ezrin/radixin/moesin family
      0.053   13.6   3.1      0.053   13.6   3.1    3.3  3  TRPM_tetra       Tetramerisation domain of TRPM
       0.06   13.0   4.6       0.28   10.8   0.6    2.1  2  Pterin_bind      Pterin binding enzyme
          2    8.6   8.8        0.6   10.2   3.0    2.5  2  DASH_Dad3        DASH complex subunit Dad3
          2    8.0   7.8        1.7    8.3   1.4    2.3  2  DUF4988          Domain of unknown function
        2.8    8.1  27.4        8.6    6.5   1.1    3.0  2  Fib_alpha        Fibrinogen alpha/beta chain family
        6.3    6.9  13.0       0.74    9.9   4.2    2.7  3  Sin3_corepress   Sin3 family co-repressor
        6.5    7.0  15.7        8.3    6.7   0.2    3.5  3  XhlA             Haemolysin XhlA


Domain annotation for each model (and alignments):
>> PP-binding_2  Acyl-carrier
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.1   1.2e-05     0.024      38      90 ..     136     191 ..     113     195 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.2e-05
  PP-binding_2  38 lrtredrlwdgldtvefvedveelfdvivs...devadnfetlqeiadlvvaerak 90 
                   ++ r+  +   +dt ++v d ++ fd +++      +d fe ++eia++  +e +k
    EFC35488.1 136 IQKRNACMNIRIDTTHIVADHKQNFDSTLTsceKSQMDTFEYIKEIAQYTSSEMQK 191
                   56788888999***************99862224689************9999887 PP

>> ERM  Ezrin/radixin/moesin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8  19.2   1.9e-05     0.038       3     160 ..      15     168 ..      13     204 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.9e-05
         ERM   3 aerekreleerLkqlqeeaekaqeaLreseetaelLaekarraeeeaelLeqkaaeaeeeiqrlkesaekeeeekeklerklreaeleaarleeeserk 101
                 ++++k+ l+ +L +lq+++++aqe   e+      L++ ++  +e   +L + ++++    +++k++     ee  ++e+++++ e+  +r+++e+ + 
  EFC35488.1  15 VKQKKSILKTQLNSLQSQIQQAQELSIEKDHILLDLEQVLQDQQELHHNLMEAHSKLDDIYSQMKQH---HTEELLQIEKRIKATEEYSQRVHNEKIEY 110
                 578999***************************************9999999999999999999875...57999*****************9999887 PP

         ERM 102 eeeaerLkeeleeareaeeeakekllealstpsks........eseenveeseteeeeenseeesae 160
                  ++ +  ++el+ a+ +e+ ake+   + ++++          +    v+ ++++ ++     +s+e
  EFC35488.1 111 RHQLD--QNELIIAQLEETIAKEEAYFIQKRNACMniridtthI----VADHKQNFDSTL---TSCE 168
                 76666..899************9999888888544766543331....332222222222...2222 PP

>> TRPM_tetra  Tetramerisation domain of TRPM
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   3.1   2.7e-05     0.053      17      46 ..      11      40 ..       9      50 .. 0.94
   2 ?   -1.2   0.1       1.1   2.2e+03      40      49 ..      69      78 ..      44      84 .. 0.67
   3 ?    0.5   0.3      0.34   6.8e+02       2       9 ..      91      98 ..      90     135 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.7e-05
  TRPM_tetra 17 kveevneKenlikaSLqsldfrLgkLedls 46
                ++++v++K ++ k+ L sl +++++ ++ls
  EFC35488.1 11 RINDVKQKKSILKTQLNSLQSQIQQAQELS 40
                899**************************8 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.1
  TRPM_tetra 40 gkLedlsalt 49
                +kL+d+  ++
  EFC35488.1 69 SKLDDIYSQM 78
                3566666555 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.34
  TRPM_tetra  2 eRIrvttE 9 
                +RI++t E
  EFC35488.1 91 KRIKATEE 98
                67777765 PP

>> Pterin_bind  Pterin binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.6   0.00014      0.28     124     190 ..       2      69 ..       1      83 [. 0.76
   2 ?    4.0   0.3     0.017        34     137     197 ..     122     183 ..      79     190 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00014
                  SECSSTTTHCCCC.CCCSSHHHHHHHHHHHHHHHHHHTT--GGGEEEETTTTSSTTHHHHHHHHHTHH CS
  Pterin_bind 124 hmrgtpktmqeee.gqyedvveeveaflearveaaeeaGvaperillDpgigfgkteehnlellrrld 190
                  ++ +t ++++ +   q++++ +     l++++++a+e  ++++ illD     + ++e + +l+++ +
   EFC35488.1   2 TFSTTFNRWRINDvKQKKSILKTQLNSLQSQIQQAQELSIEKDHILLDLEQVLQDQQELHHNLMEAHS 69 
                  555566667777777999999****************************9999666665555555433 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.017
                  CCCSSHHHHHHHHHHHHHHHHHHTT--GGGEEEETTTTS.STTHHHHHHHHHTHHHHHHTTS CS
  Pterin_bind 137 gqyedvveeveaflearveaaeeaGvaperillDpgigf.gkteehnlellrrldelreale 197
                   q e+++++ ea++ ++++a+ +  ++++ i+ D    f +  +  + + +++++ ++e+ +
   EFC35488.1 122 AQLEETIAKEEAYFIQKRNACMNIRIDTTHIVADHKQNFdSTLTSCEKSQMDTFEYIKEIAQ 183
                  46678888899999999*****************9999984444455555555555555444 PP

>> DASH_Dad3  DASH complex subunit Dad3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.7      0.18   3.7e+02      13      38 ..      20      47 ..      13      52 .. 0.63
   2 ?   10.2   3.0    0.0003       0.6       6      48 ..      51      93 ..      47      96 .. 0.94

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.18
   DASH_Dad3 13 erLaenlktLaselkeLasn..steeil 38
                + L+++l++L+s++++ ++   ++++il
  EFC35488.1 20 SILKTQLNSLQSQIQQAQELsiEKDHIL 47
                5688999999999976544433344454 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.0003
   DASH_Dad3  6 qevLdeYerLaenlktLaselkeLasnsteeildgLReLErki 48
                ++vL+  ++L +nl +  s+l+++ s+ +++ +++L ++E++i
  EFC35488.1 51 EQVLQDQQELHHNLMEAHSKLDDIYSQMKQHHTEELLQIEKRI 93
                47**************************************998 PP

>> DUF4988  Domain of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   1.4   0.00083       1.7       4      51 ..      11      59 ..       9      67 .. 0.86
   2 ?    3.5   0.6     0.025        49       5      52 ..      86     136 ..      83     173 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00083
     DUF4988  4 dvndlkdrvaaleeqvkelndniealkkll.eegkviteveensdgsyv 51
                ++nd+k++ + l++q+++l+++i++ ++l  e+ +++ ++e++ + + +
  EFC35488.1 11 RINDVKQKKSILKTQLNSLQSQIQQAQELSiEKDHILLDLEQVLQDQQE 59
                79***************************97888888888887666555 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.025
     DUF4988   5 vndlkdrvaaleeqvkel.ndniealkklleegkviteveen..sdgsyvl 52 
                 + ++++r++a ee  + + n++ie  ++l +++ +i ++ee+  ++ +y +
  EFC35488.1  86 LLQIEKRIKATEEYSQRVhNEKIEYRHQLDQNELIIAQLEETiaKEEAYFI 136
                 55799*******998887589999999999999999999985223445665 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5  18.8     0.037        73      28     128 ..      17     131 ..      11     134 .. 0.70
   2 ?    6.5   1.1    0.0043       8.6      34      78 ..     154     198 ..     146     208 .] 0.77

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.037
                 CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH.....H..HHHHHHHHHHHHHCCCHHHHHHHCCHHHHH.......HHHHHHH CS
   Fib_alpha  28 kyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqkskkd.....n..dnvikksskeleeeilrlketidaqesnir.......vLqnvle 112
                 ++++ +k++l++l+++++++++ + e +++  +++++l+++q+ +++     +  d ++++++++  ee l+++++i+a+e+  +       + +  l+
  EFC35488.1  17 QKKSILKTQLNSLQSQIQQAQELSIEKDHILLDLEQVLQDQQELHHNlmeahSklDDIYSQMKQHHTEELLQIEKRIKATEEYSQrvhnekiEYRHQLD 115
                 455667889999999999999999999999999999999999888875555414689999999998889999999998877444301111113455666 PP

                 HHHHHHHHHHHHHHHH CS
   Fib_alpha 113 sneqkiqkLeqdidqk 128
                 +ne  i++Le+ i++ 
  EFC35488.1 116 QNELIIAQLEETIAKE 131
                 6666677777766655 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0043
                 CHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  34 kkdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnv 78 
                  ++ ++  ++l++ ++s+ +++e++kei +++ ++ ++  +n+++
  EFC35488.1 154 ADHKQNFDSTLTSCEKSQMDTFEYIKEIAQYTSSEMQKCINNSSA 198
                 5555788899********************999888776655443 PP

>> Sin3_corepress  Sin3 family co-repressor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.1      0.47   9.3e+02      52      91 ..      25      64 ..       7      73 .. 0.68
   2 ?    9.9   4.2   0.00037      0.74      27      90 ..      68     130 ..      49     135 .. 0.85
   3 ?    1.8   0.5      0.13   2.5e+02      47      91 ..     151     196 ..     143     202 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.47
  Sin3_corepress 52 rknqyeealfrcEderyelDmvieanrstiklleelakki 91
                    + n++  ++ +  +  +e D ++  ++++++  +el +++
      EFC35488.1 25 QLNSLQSQIQQAQELSIEKDHILLDLEQVLQDQQELHHNL 64
                    4466667777777777777777777777777777776665 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00037
  Sin3_corepress  27 kevLNdewvsvptwasedsgsfkasrknqyeealfrcEderyelDmvieanrstiklleelakk 90 
                     ++ L d +  + + ++e+   ++ +r  + ee   r+  e++e+   ++ n+ +i++lee+  k
      EFC35488.1  68 HSKLDDIYSQMKQHHTEEL-LQIEKRIKATEEYSQRVHNEKIEYRHQLDQNELIIAQLEETIAK 130
                     5678888888888888887.4888899********************************98765 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.13
  Sin3_corepress  47 sfkasrknqyeealfrcEderye.lDmvieanrstiklleelakki 91 
                     + +a +k+++  +l+ cE   ++ ++++ e  + t ++++++ ++ 
      EFC35488.1 151 HIVADHKQNFDSTLTSCEKSQMDtFEYIKEIAQYTSSEMQKCINNS 196
                     456779999999*****99877625666666666777777666655 PP

>> XhlA  Haemolysin XhlA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.2    0.0042       8.3      19      43 ..      11      35 ..       5      39 .. 0.89
   2 ?    3.1   0.4     0.056   1.1e+02      20      49 ..      50      79 ..      42      79 .. 0.84
   3 ?    3.9   4.2     0.031        62       4      48 ..      84     128 ..      81     129 .. 0.92

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0042
        XhlA 19 rvdkleekaaeaeekiknleedlkk 43
                r++++++k++  ++++ +l+ ++ +
  EFC35488.1 11 RINDVKQKKSILKTQLNSLQSQIQQ 35
                9********************9976 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.056
        XhlA 20 vdkleekaaeaeekiknleedlkklesnqk 49
                ++++ +++ e   ++++++ +l+++ s++k
  EFC35488.1 50 LEQVLQDQQELHHNLMEAHSKLDDIYSQMK 79
                55666899999999**********999887 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.031
        XhlA   4 erlerietkldnleervdkleekaaeaeekiknleedlkklesnq 48 
                 e+l +ie++++  ee  +++ + + e + +++++e  +++le+++
  EFC35488.1  84 EELLQIEKRIKATEEYSQRVHNEKIEYRHQLDQNELIIAQLEETI 128
                 8899***********6689***********************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3324  (0.185398); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.72u 0.37s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 1135.34
//
Query:       EFC35489.1  [L=1135]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.7e-05   23.3   0.5    7.7e-05   23.3   0.5    4.2  5  RNase_T   Exonuclease


Domain annotation for each model (and alignments):
>> RNase_T  Exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0      0.38   6.7e+03      27      82 ..      59     113 ..      48     121 .. 0.67
   2 ?    0.0   0.5     0.061   1.1e+03      60      89 ..     157     186 ..     128     244 .. 0.74
   3 ?   -0.7   0.1       0.1   1.8e+03      61     142 ..     420     492 ..     412     499 .. 0.65
   4 ?   -1.9   0.0      0.24   4.3e+03      32      63 ..     675     705 ..     667     711 .. 0.77
   5 !   23.3   0.5   4.3e-09   7.7e-05       1     160 [.     890    1046 ..     890    1051 .. 0.61

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.38
                 ETTCCEEEEEEEEEEEHSSHCSSSHHHHHHHHH..CHHHHHTCEBHHHHHHHHHHHHH CS
     RNase_T  27 dggeneigetfhfyvkptelakltdecteftgi..tqemldeapsfkevleefkellr 82 
                  ++ +   +++++ ++ + +  l+ +++++++i  ++ +l +  s+  + + +++llr
  EFC35489.1  59 HNKNR-KSDSCVKCCDLKSK--LDTNLQKVHKIleNPNTLPPYSSIIPYPQVMYQLLR 113
                 44443.44457777877777..999999999993334557777777767777776666 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.061
                 CHHHHHTCEBHHHHHHHHHHHHHHHTCCCE CS
     RNase_T  60 tqemldeapsfkevleefkellrklallva 89 
                  + ++++++ ++e le ++el++ +++++ 
  EFC35489.1 157 KDPTIENKQCEQELLENEQELIENEQEFIE 186
                 456678888888888888888887766665 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.1
                 HHHHHTCEBHHHHHHHHHHHHHHHTCCCETTTCEEEESSHHHHHHHHHHHHHHHHHCSEHCECHHHHHHHHHCHHHHHHHHH CS
     RNase_T  61 qemldeapsfkevleefkellrklallvahnaafdvgflraadkrilkkevpkrnqfldtlildkatlkelartsldklaek 142
                  +m+++ +  ++ ++ +++llr+  ++ +  ++++v++ ++++k   ++++   n ++   i++   +k + +  ++ l e 
  EFC35489.1 420 LKMVCGCADGEADAKNLQKLLRE--KIDP--NFIFVTDYVHNFKN--QRNCL-FNGTILKNINMSTLIKLMNN--YPHLYEM 492
                 56666666667778888889993..4555..69999999999996..77787.66666666665555544444..4444444 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 0.24
                 EEEEEEEEEEEHSSHCSSSHHHHHHHHHCHHH CS
     RNase_T  32 eigetfhfyvkptelakltdecteftgitqem 63 
                  i+++f+ + k++ +  l++++t+++++    
  EFC35489.1 675 NIDPNFVELTKDEIN-ALDKWLTKVNHNIEGY 705
                 478888888888776.9999999999987665 PP

  == domain 5  score: 23.3 bits;  conditional E-value: 4.3e-09
                  EEEEEEESSSTTCTTS-EEEEEEEEEETTCCEEEEEEEEEEEHSSHCSSSHHHHHHHHHCHHHHHTCEBHHHHHHHHHHHHHHH....TCCCETTTC CS
     RNase_T    1 vviDlEttgldakekdeiieiaaisidggeneigetfhfyvkptelakltdecteftgitqemldeapsfkevleefkellrkl....allvahnaa 93  
                  vv+DlEttgl +   +ei++++ is+ ++       f++y+kp+ +   +  + +++     ++++ +  ++++  ++ +l k+    a++  h ++
  EFC35489.1  890 VVLDLETTGLMP-NDHEIVQVGMISLISKC-----AFSIYIKPKYH-DWSSHAKKLHVDKMNEINNGKQLDQIIIPIHNYLTKNnsctAVVLVHSTS 979 
                  8***********.7*************997.....7*********9.88889999998888888888888884444555555453444344444455 PP

                  EEEESSHHHHHHHHHHHHHHHHHCSEHCECHHHHHHHHHC........HHHHHHHHHTTCHSSSSTSSHHHHHHH CS
     RNase_T   94 fdvgflraadkrilkkevpkrnqfldtlildkatlkelar........tsldklaeklgleedgraHrAldDaea 160 
                   d +fl +a+ ++           +d ++++  +  e++         +  +k + +  ++ +g aH+A  D+ +
  EFC35489.1  980 LDRNFLMKALTKH--------GLPIDRYMIVNTISEEFFPkqkletlfNQVNKPMNTTTKDIIGVAHDAAFDTAM 1046
                  5555555555554........222333333222222222232223333333333333344444447777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1135 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1404  (0.0783089); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.89u 0.31s 00:00:01.20 Elapsed: 00:00:00.53
# Mc/sec: 6504.55
//
Query:       EFC35490.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
        6.3    6.9   6.8        1.6    8.8   1.4    2.3  2  TcdB_toxin_midC  Insecticide toxin TcdB middle/C-terminal reg


Domain annotation for each model (and alignments):
>> TcdB_toxin_midC  Insecticide toxin TcdB middle/C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.3     0.032   5.8e+02     109     138 ..     107     136 ..      60     143 .. 0.81
   2 ?    8.8   1.4   8.9e-05       1.6      99     142 ..     173     216 ..     170     220 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.032
  TcdB_toxin_midC 109 lpeelwessvdeqQtklrltetessvtnli 138
                      l  +   ss+++qQ++   t + + + n++
       EFC35490.1 107 LLTSQPLSSFNKQQQQDDTTSKLNLYNNNN 136
                      444555689999999999998888888776 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 8.9e-05
  TcdB_toxin_midC  99 kpeanPypdtlpeelwessvdeqQtklrltetessvtnliedse 142
                       ++++P  +++p+++++++++ qQ+     e+++  ++  ++++
       EFC35490.1 173 TDDISPSLSITPKSHYHHHFEPQQQEHNAIEEQHDSHHSLHSNN 216
                      5789999999****************999999999999986665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1398  (0.0779742); expected 358.6 (0.02)
Passed bias filter:                      221  (0.0123264); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.37s 00:00:01.02 Elapsed: 00:00:00.57
# Mc/sec: 1844.73
//
Query:       EFC35491.1  [L=273]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-07   31.8   0.0    2.7e-07   30.9   0.0    1.5  1  Helicase_C  Helicase conserved C-terminal domain


Domain annotation for each model (and alignments):
>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   0.0   1.5e-11   2.7e-07      45     111 .]       2      71 ..       1      71 [. 0.91

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 1.5e-11
                 EESTTSTHHHHHHHHHHHH..TTSSS.EEEESGGGTSSSTSTTESEEEESSSSSSHHHHHHHHTTSSSTT CS
  Helicase_C  45 vlhgelpqnereeileqfn..kgesd.vLiatdvaerGidipkvnlVinfdlprnvtsyiqriGRtgRag 111
                 +++g++p ++r+  +++ n   ++++ +Li+t ++ +Gi++ ++n V  +d+ +n+++   +++R+ R+g
  EFC35491.1   2 RFDGSTPFDQRQSCIDKINdnTNNITvLLISTLAGCEGINLMGANRVALIDVNWNPSHDSEAVCRVFRIG 71 
                 579***************96556667678***************************************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (273 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       638  (0.0355848); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.34s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1557.95
//
Query:       EFC35492.1  [L=253]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      9e-76  255.4   0.0      1e-75  255.2   0.0    1.0  1  Peptidase_M18  Aminopeptidase I zinc metalloprotease (M18)
  ------ inclusion threshold ------
       0.12   12.2   0.2       0.86    9.5   0.1    2.0  2  DUF2612        Protein of unknown function (DUF2612)


Domain annotation for each model (and alignments):
>> Peptidase_M18  Aminopeptidase I zinc metalloprotease (M18)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  255.2   0.0   1.1e-79     1e-75       1     228 [.      21     253 .]      21     253 .] 0.93

  Alignments for each domain:
  == domain 1  score: 255.2 bits;  conditional E-value: 1.1e-79
                    HHHH--SHHHHHHHHHHHHHCTT-EESTTTS.-ST..STTCEEEEEEETTTEEEEEEEETTS-GG.G--EEEEEE---SEEEEECCEEEEETTEEE CS
  Peptidase_M18   1 finksptpyhvvaevaekllkagfkelseke.kwk..iepggkyfvtrngssliAFavgkkykae.ngfsiigaHtDsptlrvKpkskkkaegylq 92 
                    fin+s++pyh+v  ++++ll+ g+++l e+e +w+  i+p gkyf trn+s+++AFavg+k+ a+ +g++iigaHtDsp l +Kp+s++k++gylq
     EFC35492.1  21 FINESKSPYHAVGSIKKRLLDSGYEQLFEREaNWEqkIKPCGKYFFTRNHSTIVAFAVGGKFAAGtSGLKIIGAHTDSPHLVIKPISSQKSSGYLQ 116
                    9**************************98764899999************************99747***************************** PP

                    EEEEEESS.SSGGGTT--EEEEEEEEECTT--EEEEEECCSTT---BBB----GGG-GG..G.SS--TTTTTSEEEEEEEE------TTCCC..T. CS
  Peptidase_M18  93 vgvetYGggiwetWldrdLsvaGrvlvkkkkeekleaklvnierPvlriPnlaiHLdrdine.efkfneetelepilglaeeeeeekedkek..kn 185
                    vgv+tYGgg w+tW+drdL+vaGrv++ +  ++k ++ lv+++rP+lriP+laiHL+r++ +  fk+n+e +l pi+g++   e+  + ++k    
     EFC35492.1 117 VGVQTYGGGLWYTWFDRDLTVAGRVILSDG-QGKFKQHLVEVKRPILRIPSLAIHLQREVSTdGFKPNTELHLLPIIGTEL-GELSDDPNTKgfIA 210
                    *****************************9.79**************************975269**************65.34444444553348 PP

                    CCHHHHHHHHHHHHTS-CCCCCCCEEEEEE-S--EEETTTT-E CS
  Peptidase_M18 186 khkkalleliaeelgvevedivdlelilvdaqkakivGiekef 228
                    +h+++ll+ iaeel+++v+di d+++ ++d+q+++i+G+++ef
     EFC35492.1 211 NHHSVLLKAIAEELKCNVADIRDFDMSIADVQPGVIGGVNNEF 253
                    9****************************************98 PP

>> DUF2612  Protein of unknown function (DUF2612)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.1   9.6e-05      0.86      45      96 ..      84     137 ..      83     149 .. 0.89
   2 ?    0.1   0.0     0.074   6.6e+02     117     150 ..     205     238 ..     203     243 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 9.6e-05
     DUF2612  45 AegkgLDvwGrivgvsrvltvplsk.kyfgFdeag.lgFdqgsfkrrsdsttgl 96 
                 A + gL ++G++ + +  +  p+s+ k  g+ + g + ++ g +++ +d++ ++
  EFC35492.1  84 AGTSGLKIIGAHTDSPHLVIKPISSqKSSGYLQVGvQTYGGGLWYTWFDRDLTV 137
                 6678************999999999678***99999************998765 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.074
     DUF2612 117 wdgtvpninailrslfadggrvfvlDngdmtmtv 150
                 ++g ++n  ++l + +a++ ++ v D  d +m++
  EFC35492.1 205 TKGFIANHHSVLLKAIAEELKCNVADIRDFDMSI 238
                 5677888888888888899999999998888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       362  (0.0201908); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1488.37
//
Query:       EFC35493.1  [L=147]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.092   12.5   0.6       0.12   12.2   0.6    1.3  1  FAM209    FAM209 family


Domain annotation for each model (and alignments):
>> FAM209  FAM209 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.6   6.7e-06      0.12      60      96 ..      17      53 ..       5      99 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.7e-06
      FAM209 60 sekskeqtppglrgcsfrsplkKkqkaspskdyafnt 96
                +ek++++t +++ ++s++ p +Kk++a p+k ++f+ 
  EFC35493.1 17 KEKKSATTTTSRSTFSLGIPFRKKKEAPPDKSSTFTG 53
                35566667778888999****************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (147 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       515  (0.0287244); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 856.73
//
Query:       EFC35494.1  [L=234]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0077   16.2   1.1       0.01   15.8   1.1    1.1  1  CemA      CemA family
  ------ inclusion threshold ------
      0.017   15.0   1.2      0.022   14.6   1.2    1.2  1  Mei5      Double-strand recombination repair protein
      0.019   15.1   0.8      0.026   14.6   0.8    1.2  1  UPF0242   Uncharacterised protein family (UPF0242) N-terminus
      0.022   14.0   1.9       0.03   13.6   1.9    1.1  1  Frigida   Frigida-like protein


Domain annotation for each model (and alignments):
>> CemA  CemA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   1.1   2.2e-06      0.01      46     154 ..      82     194 ..      59     204 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.2e-06
        CemA  46 lflnkeleeealeel.kefe.ekleleeligeape..lseeeieeelkekaeelakeyreesseaiknifadlvsliafvvllllskeeleilksflde 140
                 +  n++ e e l+ + ke++ +kl l+  ig++++   + +e ++elk++a+e    ++ ++++++  i  d+++   f  l l ++++ +++   +++
  EFC35494.1  82 FSENDRREMENLRAIiKEYKaKKLVLDYEIGQKENniKTLKENNTELKSEADESFAVWNLTRQDTLDFISEDITASYDFGDLSLSEEDRAAVVIFLIQS 180
                 444455555555544144442467888889988775455788999****************************************************** PP

        CemA 141 vlygLsDsaKafli 154
                  + +L D  K  ++
  EFC35494.1 181 NICSLFDADKNNVL 194
                 *******9997665 PP

>> Mei5  Double-strand recombination repair protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   1.2     5e-06     0.022      99     156 ..      76     134 ..      39     153 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 5e-06
                 XXXX...............XXXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--HHH CS
        Mei5  99 cksesslilns..lkekielekkeLeeekakLekqvrekeelLrrLklvkkyeskndlse 156
                  + +ss+  n+  ++e++   +ke +++k+ L++++  ke+++++Lk+ +  e k++ +e
  EFC35494.1  76 DQIDSSFSENDrrEMENLRAIIKEYKAKKLVLDYEIGQKENNIKTLKENN-TELKSEADE 134
                 3333555555411567888899*************************864.677777766 PP

>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.8   5.8e-06     0.026      75     131 ..      80     137 ..      47     160 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 5.8e-06
     UPF0242  75 aklteld.eglktkeealeelqeeeeeLkeeldakeeelerlkeenqqLqekleaiae 131
                 +  +e+d  ++++ +  ++e ++++  L  e+ +ke++++ lke+n +L++++ ++ +
  EFC35494.1  80 SSFSENDrREMENLRAIIKEYKAKKLVLDYEIGQKENNIKTLKENNTELKSEADESFA 137
                 4445555567788888999999999999999******************988777544 PP

>> Frigida  Frigida-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   1.9   6.7e-06      0.03     204     287 ..      51     131 ..      39     133 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 6.7e-06
     Frigida 204 LtdkfsPvs.lLksylkeskksakkilkegnns.aaqkeanekelaaLkavikcieehkleselplesLkkriaqLekakaekkra 287
                 Ltd+++P +   k+ l++s  +a+      +   ++ +e++++e++ L+a+ik  +++kl  +++  + ++ i+ L+++++e k++
  EFC35494.1  51 LTDEYKPFKpTNKAPLNQSVATASAD----Q-IdSSFSENDRREMENLRAIIKEYKAKKLVLDYEIGQKENNIKTLKENNTELKSE 131
                 55555555445555555544443333....2.2368899****************************************9999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (234 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1066  (0.0594567); expected 358.6 (0.02)
Passed bias filter:                      583  (0.0325172); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 1558.57
//
Query:       EFC35495.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.23   11.9   7.9       0.49   10.8   7.9    1.5  1  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   7.9   2.7e-05      0.49       6      23 ..      44      61 ..      40      66 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 2.7e-05
       EGF_2  6 eiCgghGtCvnqcGq.CdC 23
                + C+g+G C  ++G  C+C
  EFC35495.1 44 DSCNGRGFCS-TTGDsCQC 61
                46*******8.46755*** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       535  (0.0298399); expected 358.6 (0.02)
Passed bias filter:                      245  (0.013665); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.46
# Mc/sec: 691.18
//
Query:       EFC35496.1  [L=444]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.1e-09   35.4   0.6    1.1e-08   34.7   0.6    1.4  1  Transposase_21  Transposase family tnp2
     0.0002   20.9   0.1    0.00035   20.2   0.1    1.4  1  DUF1258         Protein of unknown function (DUF1258)


Domain annotation for each model (and alignments):
>> Transposase_21  Transposase family tnp2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.7   0.6   1.2e-12   1.1e-08      26     151 ..     178     293 ..     166     316 .. 0.78

  Alignments for each domain:
  == domain 1  score: 34.7 bits;  conditional E-value: 1.2e-12
  Transposase_21  26 dprnvrlglatdGfnPfgsmsssysvWpvllipynlPPWlclkqsnfllsllipGpksPgkdidvylePlvddlkelweeGvetydalkeekfnl 120
                     ++ ++ l +  dG  Pf   ss++s+Wp+ ++  nlPP +  + +n+++  l  G+++Pg+   v+l+ +v+d+k++ ++ v   +++   +f  
      EFC35496.1 178 NSNQIFLQVNWDGASPFS--SSKWSMWPIYVVVQNLPPEVRYNPENLFMVGLWYGKTKPGN---VFLDYFVQDVKSMENNEVIINNGSWFVNF-- 265
                     56678888999******9..99**************************************6...9************9999987766554444.. PP

  Transposase_21 121 ravllwtindfPalstlsGlst.kgklacvtC 151
                            + d Pa ++   +s+ +g ++c  C
      EFC35496.1 266 ----CSIVCDLPAKAIAYCMSAfNGLFGCGFC 293
                     ....2334455555554444322455555555 PP

>> DUF1258  Protein of unknown function (DUF1258)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.1   3.9e-08   0.00035     102     219 ..     186     303 ..     153     334 .. 0.83

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 3.9e-08
     DUF1258 102 lsidGvsikGnkk.klWPvslilvdlPvaemqkstnillegivecsenPstalWnallPlilsdlesktGkvkkvkfkarivtltadqPakrslfGlra 199
                 +  dG s   ++k  +WP+ +++ +lP        n+ + g+  +  +P  ++ + ++  +   +e++   +++ ++ ++  ++  d Pak   + + a
  EFC35496.1 186 VNWDGASPFSSSKwSMWPIYVVVQNLPPEVRYNPENLFMVGLWYGKTKPGNVFLDYFVQDV-KSMENNEVIINNGSWFVNFCSIVCDLPAKAIAYCMSA 283
                 566888776677769***********************************99998888765.568999999**************************** PP

     DUF1258 200 hqsekscffclstgtlykke 219
                  +    c fcl +g   +++
  EFC35496.1 284 FNGLFGCGFCLNSGHSIQRR 303
                 ***********998765544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (444 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       685  (0.0382063); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.25s 00:00:00.80 Elapsed: 00:00:00.43
# Mc/sec: 3092.03
//
Query:       EFC35497.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.08   11.9   0.0       0.12   11.3   0.0    1.4  1  DDE_Tnp_ISAZ013  Rhodopirellula transposase DDE domain
       0.19   11.6   1.8        9.3    6.1   0.0    2.9  3  BING4CT          BING4CT (NUC141) domain


Domain annotation for each model (and alignments):
>> DDE_Tnp_ISAZ013  Rhodopirellula transposase DDE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   1.4e-05      0.12     183     244 ..      14      75 ..      11     132 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.4e-05
  DDE_Tnp_ISAZ013 183 llitaDaggsnssrsrlwkkelqkladelgleiqva.hfPpgtskwnkiEhRlfshitqnwrg 244
                      +++  D++ +    +r  + +++ l +  +l + ++  + p +sk+n++E R ++++++ + g
       EFC35497.1  14 IMVSSDNDHKFAPSNRKGQVRMAFLWEIFNLDVLIHsSYAPNCSKYNRVE-REMAQLSKVLIG 75 
                      67788888888888888889999999999999999736************.988988887766 PP

>> BING4CT  BING4CT (NUC141) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.2    0.0069        62      49      72 ..      80     103 ..      74     107 .. 0.89
   2 ?    6.1   0.0     0.001       9.3      49      73 ..     137     161 ..     132     163 .. 0.86
   3 ?   -3.9   0.0       1.4   1.3e+04      14      23 ..     216     225 ..     211     229 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.0069
     BING4CT  49 eanpfetkkqrrereVrsLLeKlq 72 
                 +  pf + k+ ++++ +++LeKl+
  EFC35497.1  80 DRKPFGEDKKAKQKNANAVLEKLK 103
                 5689******************97 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.001
     BING4CT  49 eanpfetkkqrrereVrsLLeKlqp 73 
                 e + f + k++ +++++sLL K++ 
  EFC35497.1 137 EIDLFLEGKNQDDEKIKSLLKKIHT 161
                 46889999***************86 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 1.4
     BING4CT  14 slrFvpfeDv 23 
                 + +F  +eD 
  EFC35497.1 216 NEHFYSYEDR 225
                 5578999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       650  (0.0362541); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 2028.04
//
Query:       EFC35498.1  [L=111]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       269  (0.0150036); expected 358.6 (0.02)
Passed bias filter:                      183  (0.0102069); expected 358.6 (0.02)
Passed Vit filter:                         9  (0.00050198); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.46
# Mc/sec: 733.06
//
Query:       EFC35499.1  [L=621]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.072   13.4   1.1       0.15   12.4   0.1    1.9  2  OmpH      Outer membrane protein (OmpH-like)


Domain annotation for each model (and alignments):
>> OmpH  Outer membrane protein (OmpH-like)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1      0.17   3.1e+03      12      30 ..     112     129 ..      89     132 .. 0.60
   2 ?   12.4   0.1   8.2e-06      0.15      21      98 ..     212     291 ..     170     293 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.17
                 HHSHHHHHHHHHHHHHHHH CS
        OmpH  12 eespegkaaqeqlekkfkk 30 
                 ++s++++a  +ql++ +k+
  EFC35499.1 112 NSSDYYEA-YQQLQANSKA 129
                 33333333.3335555544 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 8.2e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTS..-HHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHH CS
        OmpH  21 qeqlekkfkklqaeleakekelqklqeelqkkakkl.ekeekeqelqkkeqelqqkqqqka.qelqkkqqellkpildki 98 
                  eq+++ +kk++++     ++l+kl+  ++++  ++  + ++++e+q++++e   +++    +el+k+++e++++i +++
  EFC35499.1 212 VEQINSLEKKRNTQDSLISQDLEKLILGYNRRGGTSiIRGRRREEYQQMMDEAAPSLEGLVgEELMKRRNEIFQKIKNEV 291
                 567777778888888888888888888888777665559999999**********7877779*************99887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (621 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       707  (0.0394333); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.47
# Mc/sec: 3950.65
//
Query:       EFC35500.1  [L=735]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.5e-20   71.4   7.9    0.00025   20.9   0.1    8.9 10  NHL          NHL repeat
    1.5e-05   24.8   5.4      0.016   14.8   0.3    4.8  5  SGL          SMP-30/Gluconolactonase/LRE-like region
    0.00014   21.8   0.5        1.1    9.3   0.1    3.6  2  SBBP         Beta-propeller repeat
    0.00021   21.1   0.3        5.9    7.5   0.0    6.2  7  Reg_prop     Two component regulator propeller
    0.00093   19.5  28.2      0.004   17.5  10.9    5.8  6  EGF_2        EGF-like domain
  ------ inclusion threshold ------
      0.033   14.0   0.0      0.088   12.6   0.0    1.6  1  DUF2427      Domain of unknown function (DUF2427)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.013        38       1      19 [.      49      68 ..      49      76 .. 0.87
   2 !    6.9   0.9    0.0024       7.1       7      21 ..      89     103 ..      88     105 .. 0.92
   3 ?   -3.0   0.0       3.3   9.9e+03      13      21 ..     157     165 ..     156     166 .. 0.80
   4 ?   -2.8   0.0       2.8   8.4e+03       4      16 ..     204     216 ..     204     216 .. 0.90
   5 !    7.3   0.1    0.0018       5.3       1      23 [.     262     284 ..     262     285 .. 0.90
   6 ?    1.5   0.0      0.12   3.5e+02       4      19 ..     342     357 ..     339     361 .. 0.80
   7 !    9.8   0.0   0.00028      0.85       2      27 ..     401     426 ..     400     427 .. 0.86
   8 !   13.9   0.0   1.4e-05     0.042       2      27 ..     463     488 ..     462     489 .. 0.91
   9 !   20.9   0.1   8.5e-08   0.00025       3      27 ..     527     552 ..     527     553 .. 0.96
  10 ?   -0.2   0.0      0.43   1.3e+03       7      19 ..     594     605 ..     588     610 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.013
                BSSEEEEEEE.TTTEEEEEE CS
         NHL  1 fnyPhGvavd.snGdiyVaD 19
                f+y ++ ++d  nGd yVaD
  EFC35500.1 49 FRYLSSFCLDpRNGDMYVAD 68
                7888999************* PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0024
                 EEEETTTEEEEEECC CS
         NHL   7 vavdsnGdiyVaDse 21 
                 vavdsn++iyV D++
  EFC35500.1  89 VAVDSNDNIYVMDNG 103
                 8**********9986 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 3.3
                 TEEEEEECC CS
         NHL  13 GdiyVaDse 21 
                 Gdiy a+ +
  EFC35500.1 157 GDIYLAEAN 165
                 9****9865 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 2.8
                 EEEEEEETTTEEE CS
         NHL   4 PhGvavdsnGdiy 16 
                 P+ ++ +++G++y
  EFC35500.1 204 PTRISFSPTGQLY 216
                 8889999****98 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.0018
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +++P++v +dsnG+++V +s+++
  EFC35500.1 262 LSNPTSVFLDSNGNVFVGCSGTS 284
                 679****************9876 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.12
                 EEEEEEETTTEEEEEE CS
         NHL   4 PhGvavdsnGdiyVaD 19 
                 P G+ v++nGd+y aD
  EFC35500.1 342 PFGIHVTPNGDVYFAD 357
                 668999*******777 PP

  == domain 7  score: 9.8 bits;  conditional E-value: 0.00028
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                   P+++ v+++G iyV+D+  h++++
  EFC35500.1 401 KLPTSIFVTDDGTIYVSDTQLHQIRK 426
                 5699999***********99888876 PP

  == domain 8  score: 13.9 bits;  conditional E-value: 1.4e-05
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 + P G+ v+++G++y aD+ nh v++
  EFC35500.1 463 YTPMGIYVTKSGEVYFADTSNHKVRK 488
                 6788*******************987 PP

  == domain 9  score: 20.9 bits;  conditional E-value: 8.5e-08
                 SEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvqv 27 
                 yP+Gv+v+ ++G iy+aD ++h+++v
  EFC35500.1 527 YPTGVVVNeTSGSIYIADQGTHTIRV 552
                 8***********************98 PP

  == domain 10  score: -0.2 bits;  conditional E-value: 0.43
                 EEEETTTEEEEEE CS
         NHL   7 vavdsnGdiyVaD 19 
                 + + +++ iyV++
  EFC35500.1 594 IFL-KDNSIYVTE 605
                 444.9******96 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0     0.089   2.7e+02     138     165 ..      54      81 ..      34     105 .. 0.76
   2 !    4.9   0.0    0.0056        17     171     234 ..     250     310 ..     211     316 .. 0.71
   3 ?    3.7   0.2     0.013        38     116     210 ..     321     427 ..     270     436 .. 0.58
   4 !   14.8   0.3   5.4e-06     0.016     134     227 ..     401     506 ..     345     521 .. 0.70
   5 ?    0.9   0.0     0.094   2.8e+02     184     216 ..     526     559 ..     513     565 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.089
         SGL 138 GlawspdgktlYlaDsltrkiwaydvda 165
                   +++p +  +Y+aD + +k++++d ++
  EFC35500.1  54 SFCLDPRNGDMYVADDHFNKVFKIDHQT 81 
                 5678888888888888888888887643 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0056
         SGL 171 snrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfdpdGklieeiklpakrvtscaFgG 234
                  n + ++ +k + ++p ++++D++Gnv+v + g++  +  ++d ++   +k++++  t+ +F G
  EFC35500.1 250 YNGEDLLPTKVKLSNPTSVFLDSNGNVFVGCSGTSSTTGGENDARI---VKVDVNSNTASTFIG 310
                 455555555556677899999********99999998888888763...345555666666655 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.013
         SGL 116 alyrldpd.gklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge.............gepDGlavDaeGnvwvA 200
                 + +r +++ +    + ++l  p G++++p g+ +Y+aD  +  i  y+    +    + +    +++               + p +++v+ +G ++v 
  EFC35500.1 321 NTIRTKTSlKPYASIYTGLYTPFGIHVTPNGD-VYFADPSRYVIRMYNATLGTVSTIAGTMNTVCTD-SicdngqpalsahfKLPTSIFVTDDGTIYVS 417
                 45555555444666777777777777777765.6778888877777776554442222222211222.1244455777776666777777777777777 PP

         SGL 201 vwgggkvvrf 210
                   + ++++++
  EFC35500.1 418 DTQLHQIRKI 427
                 7777776666 PP

  == domain 4  score: 14.8 bits;  conditional E-value: 5.4e-06
         SGL 134 tipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge..............gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 + p  + +  d+ t+Y+ D+  ++i +++    +   +  +   +    +               +p G+ v+++G+v+ A  +++kv++++ dG  i+
  EFC35500.1 401 KLPTSI-FVTDDGTIYVSDTQLHQIRKIQNGIITAIAGTGTQCTTAGS-NtcdhgstsplrvdlYTPMGIYVTKSGEVYFADTSNHKVRKISSDGLTIT 497
                 444444.44577789*************99999985555554444444.358999999*99998779****************************9999 PP

         SGL 219 eiklpakrv 227
                 +++  a ++
  EFC35500.1 498 TVAGSAGNC 506
                 887664444 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.094
         SGL 184 gepDGlavDa.eGnvwvAvwgggkvvrfdpdGkl 216
                  +p G++v + +G +++A  g++++++++ +G++
  EFC35500.1 526 FYPTGVVVNEtSGSIYIADQGTHTIRVVSSNGSM 559
                 5678889988899999999999999999999875 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.1   0.00038       1.1      18      28 ..      89      99 ..      86     100 .. 0.92
   2 !    8.5   0.0   0.00064       1.9      14      29 ..     264     279 ..     261     285 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00038
        SBBP 18 IavDsnGNiYv 28
                +avDsn NiYv
  EFC35500.1 89 VAVDSNDNIYV 99
                8*********9 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00064
        SBBP  14 ygngIavDsnGNiYvt 29 
                 +++++  DsnGN++v+
  EFC35500.1 264 NPTSVFLDSNGNVFVG 279
                 799999*********7 PP

>> Reg_prop  Two component regulator propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.1   3.4e+03       9      21 ..      54      67 ..      50      70 .. 0.75
   2 ?    2.1   0.1      0.11   3.2e+02       8      20 ..      85      99 ..      79     103 .. 0.76
   3 ?   -2.4   0.0       3.2   9.7e+03       5      18 ..     104     117 ..      99     117 .. 0.71
   4 !    7.5   0.0     0.002       5.9       7      24 .]     265     282 ..     260     282 .. 0.86
   5 ?   -1.8   0.0       2.1   6.3e+03      10      21 ..     345     356 ..     340     357 .. 0.82
   6 ?    2.0   0.0      0.12   3.5e+02       8      21 ..     404     417 ..     402     420 .. 0.88
   7 ?   -2.0   0.0       2.4   7.3e+03       9      21 ..     467     479 ..     463     481 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.1
                EEEE-TTS.CEEEE CS
    Reg_prop  9 aileDsdG.rlWvG 21
                +++ D+++ +++v+
  EFC35500.1 54 SFCLDPRNgDMYVA 67
                77888888799998 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.11
                E..EEEE-TTSCEEE CS
    Reg_prop  8 t..aileDsdGrlWv 20
                +  a++ Ds+ +++v
  EFC35500.1 85 SwfAVAVDSNDNIYV 99
                3359999******98 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 3.2
                 SCEEEEEE-TTSCE CS
    Reg_prop   5 nnvtaileDsdGrl 18 
                  +v  + + s+G++
  EFC35500.1 104 VYVLRMIRASNGNI 117
                 34558889999997 PP

  == domain 4  score: 7.5 bits;  conditional E-value: 0.002
                 EEEEEE-TTSCEEEEESS CS
    Reg_prop   7 vtaileDsdGrlWvGteg 24 
                  t+++ Ds+G++ vG++g
  EFC35500.1 265 PTSVFLDSNGNVFVGCSG 282
                 57999**********975 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 2.1
                 EEE-TTSCEEEE CS
    Reg_prop  10 ileDsdGrlWvG 21 
                 i  +++G+++++
  EFC35500.1 345 IHVTPNGDVYFA 356
                 77899****997 PP

  == domain 6  score: 2.0 bits;  conditional E-value: 0.12
                 EEEEE-TTSCEEEE CS
    Reg_prop   8 taileDsdGrlWvG 21 
                 t+i+ + dG+++v+
  EFC35500.1 404 TSIFVTDDGTIYVS 417
                 699*********97 PP

  == domain 7  score: -2.0 bits;  conditional E-value: 2.4
                 EEEE-TTSCEEEE CS
    Reg_prop   9 aileDsdGrlWvG 21 
                  i+ ++ G ++++
  EFC35500.1 467 GIYVTKSGEVYFA 479
                 69999****9997 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   1.9       3.2   9.6e+03       1      12 [.     128     137 ..     126     138 .. 0.59
   2 ?   -2.3   0.6       2.1   6.2e+03      12      21 ..     504     511 ..     501     513 .. 0.61
   3 ?   -1.1   1.6      0.85   2.5e+03      23      32 .]     618     627 ..     617     627 .. 0.94
   4 !   16.7   9.2   2.4e-06    0.0072       5      32 .]     640     666 ..     632     666 .. 0.88
   5 ?    2.3   1.8     0.074   2.2e+02      23      32 .]     673     682 ..     672     682 .. 0.96
   6 !   17.5  10.9   1.3e-06     0.004       5      32 .]     695     721 ..     691     721 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.2
       EGF_2   1 CsasdeiCgghG 12 
                 Cs  d +Cg +G
  EFC35500.1 128 CS--DGNCGDGG 137
                 55..44566655 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2.1
       EGF_2  12 GtCvnqcGqC 21 
                 G C    G C
  EFC35500.1 504 GNCA--SGTC 511
                 6666..5555 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.85
       EGF_2  23 CdsgyqGktC 32 
                 C +gy G++C
  EFC35500.1 618 CRAGYGGDNC 627
                 99*******9 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 2.4e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C+++   C+C++g +G +C
  EFC35500.1 640 STVCSGNGACIESD-TCQCNAGSSGSNC 666
                 568*******9777.8************ PP

  == domain 5  score: 2.3 bits;  conditional E-value: 0.074
       EGF_2  23 CdsgyqGktC 32 
                 C sg++G +C
  EFC35500.1 673 CRSGFYGSNC 682
                 ********** PP

  == domain 6  score: 17.5 bits;  conditional E-value: 1.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG C+++   C+C+++y+G +C
  EFC35500.1 695 SSVCSGHGRCNSTD-SCSCSPNYFGGNC 721
                 789********777.7*********999 PP

>> DUF2427  Domain of unknown function (DUF2427)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   2.9e-05     0.088      31      75 ..     525     569 ..     518     579 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.9e-05
     DUF2427  31 vvyPvalvLslaksrwylpvqivnlvlavlglllghiykgstPel 75 
                 + yP+++v + ++ ++y++ q  +++ +v +  ++++y g++P +
  EFC35500.1 525 LFYPTGVVVNETSGSIYIADQGTHTIRVVSSNGSMSVYAGTFPGM 569
                 68****************************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (735 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       652  (0.0363657); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.48
# Mc/sec: 4648.85
//
Query:       EFC35501.1  [L=354]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   11.1  15.3       0.15   10.7  15.3    1.2  1  Hamartin  Hamartin protein


Domain annotation for each model (and alignments):
>> Hamartin  Hamartin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7  15.3   8.3e-06      0.15     335     476 ..       2     144 ..       1     212 [. 0.57

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 8.3e-06
    Hamartin 335 cgmttppsspgivpttelelsssasllsskvsstpeaagkatpetTPakssrklppslsesavv....valpassrksspprkdeks.esskpdlskqe 428
                 ++ ttpp+s  + +t ++ +ss  s  +++ + +++    +t +tTP+  + +++ s++ ++ +    ++ ++s  + + ++ d++s +s++++++ ++
  EFC35501.1   2 STTTTPPTSTDQENTLPIASSSGDSTTTTTTITPSS--PSNTITTTPSSPVLQQEASTTTNEPKfdfeISHNKSVYNITMKSLDSQSyDSKQSPTNHHQ 98 
                 678999999999988776555555555544444444..5677778887777765333333333335555666666666666777777777777777776 PP

    Hamartin 429 evenekeleeslkskssvtlse....Lsdvikelleaesedsvekeeeeaai 476
                 + +++++ ++ l+ ++  +++e    Ls++ +e+     ++++  e ++++i
  EFC35501.1  99 HYNTHNNNNNILN-NNNQQQQEhseiLSSLAQEQ-----QEQQVDEIQDKSI 144
                 6644444444433.23333333122244444444.....2222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2437  (0.135925); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.43
# Mc/sec: 2451.02
//
Query:       EFC35502.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.2e-05   23.2   0.1    0.00015   21.7   0.1    1.9  1  BSD         BSD domain
    0.00079   19.1  13.4     0.0011   18.6  13.4    1.2  1  SR-25       Nuclear RNA-splicing-associated protein
  ------ inclusion threshold ------
      0.038   12.4  10.8      0.048   12.0  10.8    1.3  1  Menin       Menin
       0.51   10.3  14.3       0.75    9.7  14.3    1.2  1  Suf         Suppressor of forked protein (Suf)
       0.74    8.4  13.0        1.1    7.9  13.0    1.2  1  Ndc1_Nup    Nucleoporin protein Ndc1-Nup
       0.92    8.2  15.9        1.2    7.8  15.9    1.1  1  Presenilin  Presenilin
        1.5    7.8  20.0          2    7.4  20.0    1.2  1  SLC12       Solute carrier family 12
        1.7    8.0  19.1        2.1    7.7  19.1    1.1  1  SDA1        SDA1
        1.9    8.5  14.4        2.7    8.0  14.4    1.2  1  Mucin       Mucin-like glycoprotein
        9.6    6.7  15.5         17    5.9  15.5    1.4  1  MGC-24      Multi-glycosylated core protein 24 (MGC-24), sial


Domain annotation for each model (and alignments):
>> BSD  BSD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.1   8.3e-08   0.00015      27      52 ..       1      26 [.       1      44 [. 0.94

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 8.3e-08
         BSD 27 lynelVPskvseeqFWsrYfyllrah 52
                +y+ lVP++v+  +FW+ Yfy l+ +
  EFC35502.1  1 MYDILVPKYVDDITFWKSYFYCLHRI 26
                78889****************99987 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6  13.4   6.3e-07    0.0011      19     118 ..     116     216 ..     101     242 .. 0.44

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 6.3e-07
       SR-25  19 krkksskdssrsssasksqsrkassasekee.erskekkkkkrrrsssssssssssss.sssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkk 115
                 ++++s  ++++s s s+++++     s+ ++ e ++e    +++++++  ++ss+s+s s++s+s+ ++s ++ k++ + ++k+++++ + +k+    k
  EFC35502.1 116 HQNNSNDSNENSNSDSNNNNE-IIDNSNISSnESNNETLSDNTTNTNTNIDNSSTSTStSTTSTSTPTTSTTNDKKKMNEERKRREEEYHTNKQLIEEK 213
                 333444444334444444333.33344433313333333333333333333333333303333333334444555555555555555443333333333 PP

       SR-25 116 ake 118
                  +e
  EFC35502.1 214 IRE 216
                 333 PP

>> Menin  Menin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0  10.8   2.7e-05     0.048     518     598 ..     109     201 ..      40     237 .. 0.56

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.7e-05
       Menin 518 ggdqplaeqkqkkageeserreannnnnsksnsekeadkk.................asttsnggeasstpsseseaavespse....hkeakleeksq 595
                   +q   +q++ + ++e++++++nnnn++ +ns+  ++++                 +        + st+ s+s+++ ++p+     +k+   ee+++
  EFC35502.1 109 NINQNNIHQNNSNDSNENSNSDSNNNNEIIDNSNISSNESnnetlsdnttntntnidN--------S-STSTSTSTTSTSTPTTsttnDKKKMNEERKR 198
                 3455556666666777777777777777666555433333344666654332222210........1.1222222222222222222222222233322 PP

       Menin 596 ela 598
                 ++ 
  EFC35502.1 199 REE 201
                 211 PP

>> Suf  Suppressor of forked protein (Suf)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  14.3   0.00042      0.75     156     294 ..     103     245 ..      72     246 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00042
         Suf 156 dpikkrelksetkqeeekallqkkeeqaaslees.........kvpqaqeskkrklesedssvkkPdklqmvespkkgaagrrleqqrksessksaeaa 245
                 d+i+++++++++ ++++++  +++ +      +s         +  +++es++  l++++++++     +++++ +++++++  + + +++ +k +e+ 
  EFC35502.1 103 DIIHENNINQNNIHQNNSNDSNENSN-----SDSnnnneiidnSNISSNESNNETLSDNTTNTNTNIDNSSTSTSTSTTSTSTPTTSTTNDKKKMNEER 196
                 33444444444333333322222222.....11133333444333333334444444444442222222222233356666666677777777777777 PP

         Suf 246 sksqkalqqqpaplprsivallsvLPsaqsfdgpvfnpeklvellrete 294
                 ++ +++ +++++ ++++i   +++  + ++f ++++ +e l+e +++++
  EFC35502.1 197 KRREEEYHTNKQLIEEKIREVIEIKKKVSLFSSEIITNETLIERISQSN 245
                 7788888888888******************************998775 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9  13.0   0.00061       1.1     342     485 ..      96     228 ..      90     250 .. 0.51

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00061
    Ndc1_Nup 342 likeltqrinergqpapkaapskapknkasapvkelprlsksplkkk....ddeifgnsltaeaspkssssskegvekalsslakspgqspsptarlsp 436
                 +i+++ + i    +        ++++ ++++++ ++  +++++++++    +++i  n+++ e+ + +++++++++ ++ +s+++s+ ++++pt +   
  EFC35502.1  96 IINSIDNDIIHENN----I---NQNNIHQNNSNDSNENSNSDSNNNNeiidNSNISSNESNNETLSDNTTNTNTNIDNSSTSTSTSTTSTSTPTTS--- 184
                 56666666665555....1...22222333333333333333333323455555666665666655566666666666666666555544444443... PP

    Ndc1_Nup 437 rarkllekaksrllskeqkealsestikkk.vekelaqllk.spligylFr 485
                       +++ ++ +++e+k++ +e + +k+ +e++++++++ ++  + lF+
  EFC35502.1 185 ------TTNDKKKMNEERKRREEEYHTNKQlIEEKIREVIEiKK-KVSLFS 228
                 ......44444445555555555555555524444444666332.344444 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8  15.9   0.00068       1.2     198     314 ..      73     198 ..      68     228 .. 0.36

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00068
  Presenilin 198 lLvelaqerneeifpaLiYsatvvvlaaeek......kaevaeseeeeeaekkkeeasesskeeeseeesseksaqsse.............seeesee 277
                 +++++  e  ++i   L+++ +   +  ++       +  ++ ++++ +++++++++++s++++++++e  ++s+ ss+             ++++ ++
  EFC35502.1  73 MIIKMEIENINQI---LLFEKNLNNQIINSIdndiihE--NNINQNNIHQNNSNDSNENSNSDSNNNNEIIDNSNISSNesnnetlsdnttnTNTNIDN 166
                 5566666665665...7777776665544433334321..22222222222222222222222222222222211111122233333222211111111 PP

  Presenilin 278 esseaessaeesseekeseessesseeeeeeeeeeee 314
                 +s+++++s++++s+++     +++++++++ +ee+++
  EFC35502.1 167 SSTSTSTSTTSTSTPT-----TSTTNDKKKMNEERKR 198
                 1111111111111111.....1111111111111111 PP

>> SLC12  Solute carrier family 12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4  20.0    0.0011         2      99     240 ..      65     213 ..      43     236 .. 0.36

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0011
       SLC12  99 eeYfnvihdafdlkla..vaiLrlkegldvsellqeeeeeeeekekkeaeesekeeeekkkakkkklle.............ekskekeekekleekds 182
                 e+ +++ih  + +++     iL  ++ l+ + ++++ +++  ++++ ++++ ++++++++++++++ ++             +              +s
  EFC35502.1  65 ESDCKIIHMIIKMEIEniNQILLFEKNLNNQ-IINSIDNDIIHENNINQNNIHQNNSNDSNENSNSDSNnnneiidnsnissN--------------ES 148
                 3334455554444443114577777777766.444444333333333333333222222222222222222334444433331..............33 PP

       SLC12 183 nlslseekk...................eeekekkkekkkkkekkeklkkkekslllkeaskeekevleeitqfqkk 240
                 n+++ ++++                   +  +++ +++++          ++k+++++e++++e+e  ++ + +++k
  EFC35502.1 149 NNETLSDNTtntntnidnsststststtS--TSTPTTSTT----------NDKKKMNEERKRREEEYHTNKQLIEEK 213
                 22222222222222222223332222111..111111111..........111111111111112222222222222 PP

>> SDA1  SDA1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7  19.1    0.0012       2.1      73     215 ..      85     236 ..      32     245 .. 0.45

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0012
        SDA1  73 leLlekwkeeekkekre..........eeeedsddeddeedwevesdddseedseggwidvesdeeeieesdesedeeeeeeeeeekeekeeeeeeee. 160
                 + L ek  +++  ++ +          +     ++  ++++++ +++++s+++++++ id ++ +      +es++e+ ++++ +++ + +++    + 
  EFC35502.1  85 ILLFEKNLNNQIINSIDndiihenninQ-----NNIHQNNSNDSNENSNSDSNNNNEIIDNSNISS-----NESNNETLSDNTTNTNTNIDNS----St 169
                 3344444444444443255544322210.....111112222222222222222333333322111.....1111111111111111111111....01 PP

        SDA1 161 ..............eeeeeeeeeeeeeekekkkkkakeaseeekkkekeeekiskaselattrILTpaD 215
                               + + +++++ +ee k++++ + +++++  ++k++e  +i+k+ +l ++ I+T++ 
  EFC35502.1 170 stststtststpttS-TTNDKKKMNEERKRREE-EYHTNKQLIEEKIREVIEIKKKVSLFSSEIITNET 236
                 111223334455431.22222222222222222.33333334455555666666667899999999985 PP

>> Mucin  Mucin-like glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0  14.4    0.0015       2.7      42      87 ..     143     186 ..     113     200 .. 0.47

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0015
       Mucin  42 qskltttttttkppttttttttasttittkttkatttttttttttt 87 
                  s++++   t+   tt t t+      +t t+++tt+t+t+tt+tt
  EFC35502.1 143 ISSNESNNETLSDNTTNTNTN--IDNSSTSTSTSTTSTSTPTTSTT 186
                 233333334444444333333..11112222222222222222222 PP

>> MGC-24  Multi-glycosylated core protein 24 (MGC-24), sialomucin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  15.5    0.0093        17      30      95 ..     122     187 ..     100     201 .. 0.51

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0093
      MGC-24  30 ekskcsenstvedCsvvnvtelcsaaskstpkptnstaktttkpsstttstsvatsgttnttvtpt 95 
                 +++++s++ + ++ +++ ++++ s +s++++ + n+t+++t+ + s+t++++++ts++t tt t +
  EFC35502.1 122 DSNENSNSDSNNNNEIIDNSNISSNESNNETLSDNTTNTNTNIDNSSTSTSTSTTSTSTPTTSTTN 187
                 333344444445555666666666666665555555555554444443333333333333332222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3992  (0.222656); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                       119  (0.00663729); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.71u 0.34s 00:00:01.05 Elapsed: 00:00:00.51
# Mc/sec: 1483.72
//
Query:       EFC35503.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.6e-17   62.3   4.2    7.8e-16   58.5   4.2    2.0  1  TLD       TLD


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.5   4.2   4.4e-20   7.8e-16      33     138 ..       2     146 ..       1     147 [. 0.96

  Alignments for each domain:
  == domain 1  score: 58.5 bits;  conditional E-value: 4.4e-20
         TLD  33 kkyifGaflsqpwkssnkkfygdsesflfsl..spkfkvykstgknkaylntssdglgfGggqp.kfsLwidsslekgtsrhsetfengllsg...... 122
                 +++++Gaf+s p++++++k+yg++e +l+s+  s ++k+y++t+ n++++ ++++++  Gg++  + +L+id++l +g+++ ++tf+++  s+      
  EFC35503.1   2 DGNVLGAFNSMPYNERGHKYYGNGEIMLYSFknSTNIKTYHWTKLNDFFIRSTDSMICYGGDEFgRSALIIDGELLTGSTNICKTFACSDDSNveqtpl 100
                 5689***************************9999*************************976589**********************9999999**** PP

         TLD 123 ..............................aseerfkikdiEVWgl 138
                                               ++e +f+i+ +EVWg+
  EFC35503.1 101 lekeissattpsnsgsssstlvksqsittfSTEVDFEIYALEVWGF 146
                 ******************************99*************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       514  (0.0286686); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 1040.96
//
Query:       EFC35504.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        6.5    7.1   6.3        1.4    9.3   0.6    2.5  3  Orf78     Orf78 (ac78)


Domain annotation for each model (and alignments):
>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1     0.071   1.3e+03      22      68 ..       8      61 ..       6      66 .. 0.35
   2 ?   -1.1   0.0      0.13   2.3e+03      49      71 ..      76      99 ..      68     103 .. 0.44
   3 ?    9.3   0.6   7.8e-05       1.4      28      78 ..     149     198 ..     128     215 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.071
       Orf78 22 Alndldnddndkaen.kkekksaaeknditekesn......aaekaqalnilli 68
                Al+d++n++++ +++   +++++  k+ + ++++n      ++++ ++ +il +
  EFC35504.1  8 ALRDITNTSSSLNAStLGSNNNSGLKSILISNNKNgprdsiKSTTSNTSSILST 61
                566663333322222022222222222222222223443344444444444444 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.13
       Orf78 49 itekesnaaekaqalni.llisll 71
                it++ + +++++++  + ++ +l+
  EFC35504.1 76 ITSSAAASNQQQSFNFNhMINALV 99
                344444333444444330444444 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 7.8e-05
       Orf78  28 nddndkaenkkekksaaeknditekesnaaekaqalnillisllavvcvlv 78 
                  +++++++n+++++s++++n+ t+ +++ +   +  + l++ l+ ++ + v
  EFC35504.1 149 MKKANQQSNSSNNNSNSSNNNNTTINRH-SMVSGLNEELVMELVEFFKIPV 198
                 3344444444455555555555555444.5666777889999999998866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1478  (0.0824363); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.25s 00:00:00.70 Elapsed: 00:00:00.41
# Mc/sec: 1631.53
//
Query:       EFC35505.1  [L=269]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-24   85.4   2.2    3.9e-24   85.4   2.2    2.3  2  RPN2_C    26S proteasome regulatory subunit RPN2 C-terminal d


Domain annotation for each model (and alignments):
>> RPN2_C  26S proteasome regulatory subunit RPN2 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.4   2.2   2.2e-28   3.9e-24       1     159 [.      88     243 ..      88     244 .. 0.71
   2 ?   -3.8   0.3      0.59   1.1e+04     100     103 ..     253     256 ..     247     263 .. 0.36

  Alignments for each domain:
  == domain 1  score: 85.4 bits;  conditional E-value: 2.2e-28
                 -BEEEEETTTBEE-.-EEEEES-TTTTSSS-S--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHG........------------------------- CS
      RPN2_C   1 TaiIglnkdLkiPk.fefksnakpslFaYPpeleekkekekekvatAvLSttakakarakkkekek.......eeeekeedkmdvdeekeekekkekek 91 
                 T+iIgln+dLk+P+ f fksn kps+         kke ++     A LS +aka+ r+++k++               +    + + + + ++  ++ 
  EFC35505.1  88 TSIIGLNTDLKMPSqFTFKSNQKPSI--------RKKEVTVG--PVAELSLSAKARVREERKRRRPegsatplL-----TPLTSTPTPQVDPKQLPSQP 171
                 9************66*********98........34444444..557788888888887777666623222221.....22222222222223333444 PP

                 ---------SS----SSEEEEESSSB--TTCCTTEEE-SSSSEEESSS-SSS....SEEEEEESSTSSSSSE CS
      RPN2_C  92 kekekeeekkkkekektfekleNpaRVlpaQlkyisfkkdsrYkpvkkkgtg....Givllkdkkpeeeeel 159
                 ++++k+++k+kk+ke+t+e l+NpaRV+p+Ql++isf++ srY+p+k ++++    Gi +l+d+kp+e++++
  EFC35505.1 172 SQTDKDTKKQKKKKEPTSESLTNPARVTPSQLNFISFDTTSRYVPIKLSSSSginlGINVLSDTKPGEDADI 243
                 4445555899*************************************9554412237789********9876 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 0.59
                 -SS- CS
      RPN2_C 100 kkkk 103
                 ++k+
  EFC35505.1 253 EEKE 256
                 1111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       711  (0.0396564); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1687.42
//
Query:       EFC35506.1  [L=635]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.1e-17   62.8   0.0      1e-16   61.1   0.0    1.9  1  Lipase_3       Lipase (class 3)
    5.8e-07   29.6   0.0    1.5e-06   28.3   0.0    1.8  1  MMR_HSR1       50S ribosome-binding GTPase
    1.8e-06   28.1   0.1    4.5e-06   26.9   0.1    1.6  1  Roc            Ras of Complex, Roc, domain of DAPkinase
    7.6e-05   22.2   0.1    0.00015   21.3   0.1    1.4  1  Arf            ADP-ribosylation factor family
    0.00029   19.9   1.1     0.0038   16.2   0.0    2.3  2  Spore_IV_A     Stage IV sporulation protein A (spore_IV_A)
    0.00037   20.1   0.1    0.00094   18.8   0.1    1.6  1  Ras            Ras family
     0.0006   19.4   2.4      0.011   15.3   1.4    2.6  2  GTP_EFTU       Elongation factor Tu GTP binding domain
    0.00072   19.0   0.0     0.0023   17.3   0.0    1.9  1  ATPase         KaiC
     0.0027   17.6   0.5     0.0049   16.8   0.5    1.4  1  DUF5567        Family of unknown function (DUF5567)
     0.0087   16.1   0.0      0.035   14.1   0.0    2.2  1  AAA_14         AAA domain
  ------ inclusion threshold ------
      0.013   15.6   0.1      0.013   15.6   0.1    2.2  3  Dynamin_N      Dynamin family
      0.032   13.5   0.1       0.17   11.1   0.0    2.1  3  Hydrolase_4    Serine aminopeptidase, S33
      0.036   14.7   0.0      0.058   14.0   0.0    1.3  1  Abhydrolase_6  Alpha/beta hydrolase family
      0.094   12.2   0.0       0.19   11.2   0.0    1.5  1  FeoB_N         Ferrous iron transport protein B


Domain annotation for each model (and alignments):
>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.1   0.0   8.1e-20     1e-16       1     138 [.      89     220 ..      89     223 .. 0.85

  Alignments for each domain:
  == domain 1  score: 61.1 bits;  conditional E-value: 8.1e-20
                 EEEE----------------EEE-HHHH-GTT-EEEHHHHHHHHS-HHHHHHHHHHHHHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS...--- CS
    Lipase_3   1 vvafRGtesakdwltdldfslteakellekeggkvhsgfleayeeslreqvlkelkrllekypeysivvtGHSLGgalAlLaaldlvengene...kkk 96 
                 vva+RG+ s++d+ltd++  +           g +hsgfle +++   + +l+++      ++ y++v+tGHS+Gga+ +++a+ l +  e +   k +
  EFC35506.1  89 VVAIRGSYSKSDILTDVKLIPAMNYY--G--YGVLHSGFLERAKFIPLDYFLEKI------NEGYQVVITGHSMGGAVGAILATRLMQATEAKaikKPP 177
                 79*************99876654444..3..799**********66666666665......44688************9999999999999989999** PP

                 EEEEEES----B-HHHHHHHHT-TTEEEEEE.EETT--GGG-S CS
    Lipase_3  97 vtvvtfGqPrvgnkefaklvdsqlnkkvlrv.vntnDivPrlp 138
                 ++ + fG P   + +f++++ +  +++++++ +n++D vPr  
  EFC35506.1 178 IQFIGFGVPLLADVKFKERILKDEQSNYFHFyINEKDCVPRSI 220
                 ********************988888888853899*****975 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.0   1.2e-09   1.5e-06       2     114 .]     360     470 ..     359     470 .. 0.71

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 1.2e-09
                 EEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT....TTCSHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas....eeklkplde 95 
                 v++vG+   GKSt++ + + ++a +s++  tT +i+ + ++ + +++ ++D p  +e  s+++  + +f   +   d i++v da     +   ++ +e
  EFC35506.1 360 VGVVGMKKCGKSTFVEKFLHRNANASSIIATT-EIQAYPLTSNSSNFAVWDFPH-YE--SQDHLHKVQFITSRFlLDYIVVVYDALskcdK---EECKE 451
                 89**********************99998766.677777877789*********.99..33333334444333347********7743322...22233 PP

                 HHHHHHHHTTSEEEEEEES CS
    MMR_HSR1  96 eleelleeakkplilvlnk 114
                 +++ ++++++ ++i+++nk
  EFC35506.1 452 HINVIKQSNDHRFIVLMNK 470
                 3444433367778888887 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   0.1   3.5e-09   4.5e-06       4     119 ..     362     472 ..     360     473 .. 0.69

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 3.5e-09
                 EESSTTSSHHHHHHCHCT-CCC-EE.ETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HH.HHCTS...CEEEEEEE..GHHH.HC CS
         Roc   4 lvGdsgvGKtsllkrfvedkfseke.kstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhpl.ylrea...alailvyd..srss.en 94 
                 +vG ++ GK++++++f++++ + ++  +t+ ++ +  +             ++ ++++WD+   e  + lh++ +++++   + +++vyd  s+ + e+
  EFC35506.1 362 VVGMKKCGKSTFVEKFLHRNANASSiIATTEIQAYPLT------------SNSSNFAVWDFPHYESQDHLHKVqFITSRfllDYIVVVYDalSKCDkEE 448
                 79***************988875531345554444322............13458***************98725555522234678999654433267 PP

                 HHHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  95 lkeWlkelkkvagkspvilvgnkiD 119
                  ke ++ +k+ + +  +i+++nk+D
  EFC35506.1 449 CKEHINVIKQSN-DHRFIVLMNKAD 472
                 788888887755.566788899998 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.1   1.2e-07   0.00015      12     134 ..     355     480 ..     346     517 .. 0.80

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 1.2e-07
                 TTEEEEEEEESTTSSHHHHHHHHHHSSCEE..CSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTT....ESEEEEEEETT-CTTHHHHHHHH CS
         Arf  12 kkelrilllGLDnaGKtTilkklkleelvt..tvPTigfnveeleiknlkftvwDvGGqeklRplWknYfek....tdavifvvDsadreRleeakeeL 104
                  k++ + ++G+ + GK+T ++k+ + + +   ++ T+  +   l+ +  +f vwD    e+  +l k  f +     d ++ v D+  +   ee+ke +
  EFC35506.1 355 MKNFYVGVVGMKKCGKSTFVEKFLHRNANAssIIATTEIQAYPLTSNSSNFAVWDFPHYESQDHLHKVQFITsrflLDYIVVVYDALSKCDKEECKEHI 453
                 56777889**************977655433399**********************9999999988877765233368899999999999999999999 PP

                 HHHCTSGCCTTSEEEEEEE-TTSTTSS-HH CS
         Arf 105 kalleeeelkevallvlaNKqDlpealsee 134
                 + + +++   +  ++vl NK D+    + +
  EFC35506.1 454 NVIKQSN---DHRFIVLMNKADALYKPNMN 480
                 8876554...56799*******87665544 PP

>> Spore_IV_A  Stage IV sporulation protein A (spore_IV_A)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0     3e-06    0.0038       9      39 ..     349     379 ..     342     385 .. 0.86
   2 ?    1.6   0.5     0.083   1.1e+02     194     259 ..     558     623 ..     508     633 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 3e-06
  Spore_IV_A   9 diaertngdiyigvvGpvRtGKStfikrfme 39 
                 +i++    ++y+gvvG  ++GKStf+ +f+ 
  EFC35506.1 349 QIRQELMKNFYVGVVGMKKCGKSTFVEKFLH 379
                 5777777899*******************86 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.083
  Spore_IV_A 194 seetkelaeeleekydvkvlavnveelkeedikeilekvLyefpvkeielelpkwvealekdhelk 259
                 + ++ +++ e+++k + + ++++ ++lk+ + +e++e++  ef+ ++i++++ + +e++++ ++l 
  EFC35506.1 558 KYDALKVSIEFRRKGKNSSFCFSWDKLKNLQFRELVEELKNEFDYDNIKITTKNSLEEISDMQQLL 623
                 445566666777888888899999999999999999999999999999999999999988777664 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   7.4e-07   0.00094       4     118 ..     362     475 ..     360     510 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 7.4e-07
                 EEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTE....SEEEEEEETTBHHHHHTHHHHHHHHH CS
         Ras   4 lvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrda....egillvyditsresfenvkkwveeik 98 
                 +vG + +GK++++ +f + + + +++  i +   ++   + +++ ++ +wD    e  ++l++  + ++    + i++vyd  s+   e++k+ ++ ik
  EFC35506.1 362 VVGMKKCGKSTFVEKFLHRNANASSI--I-ATTEIQAYPLTSNSSNFAVWDFPHYESQDHLHKVQFITSrfllDYIVVVYDALSKCDKEECKEHINVIK 457
                 89**************9876555433..3.55689999999***************9999999998887222245778999999999999999988888 PP

                 HHSTTTSEEEEEEETTTGGG CS
         Ras  99 rvaeenvpivLvGnKvDlee 118
                 +  +    ++++ nK+D   
  EFC35506.1 458 QSND--HRFIVLMNKADALY 475
                 8877..58888899*99765 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.079     1e+02       6      32 ..     360     386 ..     356     410 .. 0.83
   2 !   15.3   1.4   8.3e-06     0.011      87     154 ..     424     510 ..     390     625 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.079
                 EEEEESTTSSHHHHHHHHHHHTTSSCH CS
    GTP_EFTU   6 igiighvDhGKtTLtdrLlyktgaisk 32 
                 +g++g    GK+T++++ l+++ + s+
  EFC35506.1 360 VGVVGMKKCGKSTFVEKFLHRNANASS 386
                 789999999**********98887666 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 8.3e-06
                 HHHHHHT-SEEEEEEETTTB.STHHHHHHHHHHHHTTTE.EEEEEESCGST.HHHHHHHHHHHHHHHHHH.................H CS
    GTP_EFTU  87 virglrvlDgavlvvdaveG.vepqteevlrlalkegvp.iivfiNKmDrl.kaelkeiveevkqklsrk.................e 154
                  i++   lD+ v+v da +   ++  +e+++++++ + + +iv++NK+D l k +++++++   ++  r+                 +
  EFC35506.1 424 FITSRFLLDYIVVVYDALSKcDKEECKEHINVIKQSNDHrFIVLMNKADALyKPNMNMTKDHFDDTR-REcslklgvdisrviltsvD 510
                 57788899*********877256789*******9998777***********8666666666665433.22344444445555555550 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   1.8e-06    0.0023      18      92 ..     356     428 ..     346     466 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.8e-06
      ATPase  18 egrvvlitGepGtGKtifalqFlikgaekygepgvfvtveepaedlrenakslG.wdlekleeegklaiidasesa 92 
                 ++  v ++G   +GK++f+++Fl + a+      ++ t+e +a  l  n +++  wd+ ++e++++l  ++  +s+
  EFC35506.1 356 KNFYVGVVGMKKCGKSTFVEKFLHRNANA---SSIIATTEIQAYPLTSNSSNFAvWDFPHYESQDHLHKVQFITSR 428
                 55668899******************777...9*****************999669*********99988887765 PP

>> DUF5567  Family of unknown function (DUF5567)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.5   3.8e-06    0.0049     201     232 ..     596     627 ..     589     629 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 3.8e-06
     DUF5567 201 LdEeFDYDnVaLtpKfseaEletlkelskrkr 232
                 L  eFDYDn+ +t K s  E++ +++l +++ 
  EFC35506.1 596 LKNEFDYDNIKITTKNSLEEISDMQQLLEHED 627
                 789***********************999875 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.0   2.8e-05     0.035       5      35 ..     360     389 ..     356     467 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.8e-05
      AAA_14   5 lvitGaRrvGKTtllkqlikellvkkesily 35 
                 + ++G++++GK+t+++++++++  +++si+ 
  EFC35506.1 360 VGVVGMKKCGKSTFVEKFLHRNA-NASSIIA 389
                 789****************9888.5555554 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.6   0.1     1e-05     0.013       1      33 [.     360     392 ..     360     399 .. 0.92
   2 ?   -1.5   0.0       1.8   2.3e+03     130     167 ..     432     470 ..     392     471 .. 0.60
   3 ?   -3.8   0.1         9   1.2e+04      50      67 ..     604     621 ..     584     629 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1e-05
                 EEEEEBTTTTHHHHHHHHHTS--S---SSS--- CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlgedilprgpnptTr 33 
                 + vvG+ + GKS+++++ l+++ + ++ + tT 
  EFC35506.1 360 VGVVGMKKCGKSTFVEKFLHRNANASSIIATTE 392
                 78********************99999988885 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.8
                 EEEEEEEETTS-CCC-C.HHHHHHHHSTTBTTEEEEEE- CS
   Dynamin_N 130 diilavtsanhdlsnse.alflarevdpkgkrtivvltk 167
                 d i++v +a +++ + e ++ ++   +++++r+iv+++k
  EFC35506.1 432 DYIVVVYDALSKCDKEEcKEHINVIKQSNDHRFIVLMNK 470
                 567777777776666641444444455666668888777 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 9
                 ...SSEEEET-EB--CHH CS
   Dynamin_N  50 avkeelkekekkledfse 67 
                 + k++ k+  ++++d+++
  EFC35506.1 604 NIKITTKNSLEEISDMQQ 621
                 233344444444444444 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00013      0.17      71      96 ..     138     163 ..     132     178 .. 0.76
   2 ?   -1.8   0.0       1.2   1.5e+03     117     149 ..     267     300 ..     253     316 .. 0.69
   3 ?   -3.6   0.0       4.2   5.4e+03     109     159 ..     511     560 ..     500     563 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00013
  Hydrolase_4  71 eehpelplfllGhSmGGliallyllr 96 
                  + +++ ++++ GhSmGG++ + +++r
   EFC35506.1 138 KINEGYQVVITGHSMGGAVGAILATR 163
                  4457889***********99887754 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.2
  Hydrolase_4 117 lk.appllklllkllgkllpklqvsnnlkadsls 149
                  ++ ++++ k+++k++ k +p++++ +n+   s s
   EFC35506.1 267 ISvFQWFSKVIAKVIHKYAPQFSPFGNHIHISYS 300
                  4558899999999999999999983333333333 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 4.2
  Hydrolase_4 109 Palkikaklkappllklllkllgkllpklqvsnnlkadslsrdpevvaaye 159
                  Pa++  ++l  p+ +++++++   ++ +l+ +++   + + ++   +++y+
   EFC35506.1 511 PAINNIHQL-KPWGVNMMSEIRDVIWEDLKTTAKRTVAEVEQEWNSLKKYD 560
                  444433333.67778888899999999998877777777777777777776 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   4.5e-05     0.058      56      86 ..     135     161 ..     110     221 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 4.5e-05
                    HHCCTT..TTSEEEEEETCHHHHHHHHHHCC CS
  Abhydrolase_6  56 lldelaagggpvvlvGHSlGGalalaaapla 86 
                    +l+++   g +vv+ GHS+GGa+++    la
     EFC35506.1 135 FLEKIN-EGYQVVITGHSMGGAVGAI---LA 161
                    555554.78899**********9999...55 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00015      0.19       3     128 ..     360     484 ..     358     504 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00015
                 EEEEESTTSSHHHHHHHHHTTSEEEEESTTSSSEEEEEEEEETTEEEEEEE----SSSSSSSHHHHHHHHHHHCTSSSEEEEEEEG......GGHHHHH CS
      FeoB_N   3 valvGnpnvGkttlfnaltgakqkvgNwpGvtvekkegklklkgkeveivDlPGiYslsayseeekvardflleeepdvvvnvvda......tnlernL 95 
                 v +vG   +Gk+t++++    + + +     t e +   l+ +++++ + D+P   s ++  + + ++ +fll    d +v v da      ++ + ++
  EFC35506.1 360 VGVVGMKKCGKSTFVEKFLHRNANASSIIA-TTEIQAYPLTSNSSNFAVWDFPHYESQDHLHKVQFITSRFLL----DYIVVVYDAlskcdkEECKEHI 453
                 679****************99999887765.6689999999999*********98888999999999999998....7777777772111113455555 PP

                 HHHHHHHHTTSSEEEEEETHHHHHHTTEEE-HH CS
      FeoB_N  96 yLtlqllelgvpvvlalnmideaekkgieidlk 128
                  ++ q    ++++++ +n+ d++ k ++++ ++
  EFC35506.1 454 NVIKQSN--DHRFIVLMNKADALYKPNMNMTKD 484
                 5555544..467888888888888877776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (635 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1092  (0.0609069); expected 358.6 (0.02)
Passed bias filter:                      626  (0.0349155); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.79u 0.34s 00:00:01.13 Elapsed: 00:00:00.54
# Mc/sec: 3515.82
//
Query:       EFC35507.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-11   44.9   0.9    2.1e-11   44.2   0.1    1.8  2  RNase_H   RNase H


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1      0.47   8.5e+03      77      92 ..      38      53 ..      12      59 .. 0.47
   2 !   44.2   0.1   1.2e-15   2.1e-11       5     141 ..      64     188 ..      60     190 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.47
                HHCCCHHHHHTTSSSE CS
     RNase_H 77 itqwvhrwkknawktt 92
                ++++  + kkn++k++
  EFC35507.1 38 LKEYNLTLKKNEMKFK 53
                2233333444444444 PP

  == domain 2  score: 44.2 bits;  conditional E-value: 1.2e-15
                 EEEEEEEEECTTTCEEEEE.EE.CTT......EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSB CS
     RNase_H   5 vvYtDGsclgnpgeggaga.vl.ykeg....arnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkp 97 
                  ++tDGs l  +++ g+g+ ++  + +     r +s +++++ +nn aE++ +i+a k   +d+k++i tDS+ +++ +++         ++ + ++ p
  EFC35507.1  64 DIHTDGSRL--ESKTGMGInIYdCS-NmntpVRSLSLHINDQYSNNVAEICSIITAAKVIPRDSKIKIHTDSNVAIE-VLK---------ERYKGNFLP 149
                 589****66..67777888444222.2443444777777799****************989***********99999.555.........223445556 PP

                 HTTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHH CS
     RNase_H  98 vknkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkea 141
                 +k+   ++++    +k + ++k+v++H+    +N  +D lAk+a
  EFC35507.1 150 LKK-AFFKTI--KDRKLEYEFKKVEAHKDK--ENIKVDLLAKNA 188
                 777.555555..2558899*********98..8*********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       778  (0.0433934); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1728.66
//
Query:       EFC35508.1  [L=309]
Description: Hypothetical protein NAEGRDRAFT_82366, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00099   20.1   0.2     0.0025   18.8   0.2    1.8  1  CS        CS domain


Domain annotation for each model (and alignments):
>> CS  CS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.2   1.4e-07    0.0025       3      76 .]     180     264 ..     178     264 .. 0.76

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 1.4e-07
                 CEEEEETTEEEEEEE-...TTCTTTTTCEEEE..EETTEEEEEE.TS.CEEEEECE....BSS-BETTTEEEEEETTEEEEEEEB CS
          CS   3 ydWyQtldeVvvtiyv...kkvnikkkdvkve..fkerslkvki.gk.eklliege....LfgpIdpeesswtieskkveitLkK 76 
                 + W Q+++ ++v i++   k+  ++ ++++++  +k++++++ + +k   ++ e+     L  +++++es w+i ++++ + LkK
  EFC35508.1 180 FLWKQSKEYLYVLIPMggdKGFYKQDENIELDvqIKSKRIYAAFnEKgSDIPHEKLvdseLSIEVQVDESGWCIRNSHLLLELKK 264
                 569999999999999965555444555554444499999***998666666544337778********************99999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       457  (0.0254894); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1884.79
//
Query:       EFC35509.1  [L=146]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        9.6    4.3  11.3         11    4.0  11.3    1.0  1  Nop14     Nop14-like family


Domain annotation for each model (and alignments):
>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0  11.3   0.00063        11     376     434 ..      26      83 ..       3      99 .. 0.31

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.00063
       Nop14 376 deeeeedeeeee.eeeededdlsdlese.....eeeeedeleeelleeekkaaeekkekkkkkkk 434
                 +eeee+++e  +  ee+ +ddl + +s      ee+ee+e++e    +++++++e+       ++
  EFC35509.1  26 SEEEEDNQEVMHfGEESCDDDLCSIDSTssynpEEDEEEEFDEYDYSDDEDESSER-------NT 83 
                 11111111111111222222222222112222222222222222211111111111.......11 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       907  (0.0505884); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.35s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 839.89
//
Query:       EFC35510.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-37  123.1   8.3    1.1e-05   25.1   0.1    6.2  6  LRR_6     Leucine Rich repeat
    2.4e-18   65.6   5.6    8.3e-09   35.1   1.8    2.4  2  LRR_8     Leucine rich repeat
    3.9e-16   58.9  14.6    5.7e-05   23.4   1.7    3.5  4  LRR_4     Leucine Rich repeats (2 copies)
    1.7e-11   43.0   3.1        4.6    8.2   0.1    6.0  6  LRR_1     Leucine Rich Repeat
     0.0013   18.3   3.9     0.0023   17.5   0.4    2.1  2  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
      0.033   14.1   0.3       0.82    9.6   0.2    2.4  2  DUF1825   Domain of unknown function (DUF1825)
      0.045   13.6   5.9        6.9    6.5   0.1    3.6  5  DUF2100   Uncharacterized protein conserved in archaea (DUF21
      0.056   13.2   4.0        1.5    8.7   0.3    3.3  3  Lsm_C     Lsm C-terminal


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.1   4.8e-09   1.1e-05       5      24 .]       4      23 ..       2      23 .. 0.93
   2 !   19.4   0.0   3.1e-07    0.0007       5      24 .]      28      47 ..      25      47 .. 0.92
   3 !   22.9   0.1   2.4e-08   5.4e-05       5      24 .]      52      71 ..      49      71 .. 0.92
   4 !   13.3   0.0     3e-05     0.066       5      24 .]      76      95 ..      73      95 .. 0.92
   5 !   20.9   0.0     1e-07   0.00023       5      24 .]     100     119 ..      97     119 .. 0.92
   6 !   21.3   0.1     8e-08   0.00018       5      23 ..     124     142 ..     121     143 .. 0.91

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 4.8e-09
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++++N+IgDeG++ ++
  EFC35510.1  4 LTSLNINYNNIGDEGVKLIS 23
                9****************986 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 3.1e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++++N+Ig eGa+ ++
  EFC35510.1 28 LTSLNINYNNIGVEGAKYIS 47
                9***************9885 PP

  == domain 3  score: 22.9 bits;  conditional E-value: 2.4e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+s+N+Ig eG++ ++
  EFC35510.1 52 LTSLDISDNNIGVEGVKLIS 71
                9***************9986 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 3e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L+++ N+Ig eGa+ ++
  EFC35510.1 76 LTSLNIRINEIGVEGAKYIS 95
                9***************9885 PP

  == domain 5  score: 20.9 bits;  conditional E-value: 1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+++N+Ig eGa+ ++
  EFC35510.1 100 LTSLDINCNNIGVEGAKYIS 119
                 9***************9885 PP

  == domain 6  score: 21.3 bits;  conditional E-value: 8e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+s+N+Ig eG+  +
  EFC35510.1 124 LTSLDISDNNIGVEGVRLI 142
                 9***************887 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.1   1.8   3.7e-12   8.3e-09       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   32.0   0.1   3.3e-11   7.4e-08       2      61 .]      75     134 ..      74     134 .. 0.98

  Alignments for each domain:
  == domain 1  score: 35.1 bits;  conditional E-value: 3.7e-12
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsL+++ N++ + + +  + +++L++L++++N++ +  ++ +s +++L+sLd+s+N++
  EFC35510.1  3 QLTSLNINYNNIGDEGVKLISEMKQLTSLNINYNNIGVEGAKYISEMKQLTSLDISDNNI 62
                7*********************************************************97 PP

  == domain 2  score: 32.0 bits;  conditional E-value: 3.3e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL+++ N + + + +  + +++L++Ld+++N++ +  ++ +s +++L+sLd+s+N++
  EFC35510.1  75 QLTSLNIRINEIGVEGAKYISEMKQLTSLDINCNNIGVEGAKYISEMKQLTSLDISDNNI 134
                 7*********************************************************97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   1.7   2.5e-08   5.7e-05       1      34 [.       2      37 ..       2      42 .. 0.88
   2 !   20.9   0.3   1.5e-07   0.00034       1      36 [.      50      86 ..      50      93 .. 0.81
   3 !   14.4   1.4   1.8e-05     0.039       1      36 [.      74     110 ..      74     113 .. 0.79
   4 !   22.7   0.6   4.2e-08   9.5e-05       1      34 [.      98     133 ..      98     139 .. 0.83

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 2.5e-08
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNn 34
                ++L++L+++ N++ d +  l + +++L++L+++ Nn
  EFC35510.1  2 KQLTSLNINYNNIGDEGVkLISeMKQLTSLNINYNN 37
                58*************99996655*********8884 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 1.5e-07
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36
                ++L++Ld+s+N++   +  l + +++L++L++ + n i
  EFC35510.1 50 KQLTSLDISDNNIGVEGVkLISeMKQLTSLNI-RINEI 86
                58**********99666686655********9.64444 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 1.8e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ N +   +   ++ +++L++Ld+ ++n+i
  EFC35510.1  74 KQLTSLNIRINEIGVEGAkyISEMKQLTSLDI-NCNNI 110
                 589******77999766676445*********.66566 PP

  == domain 4  score: 22.7 bits;  conditional E-value: 4.2e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++Ld++ N++   +   ++ +++L++Ld+s+Nn
  EFC35510.1  98 KQLTSLDINCNNIGVEGAkyISEMKQLTSLDISDNN 133
                 58*******99999766675445*********9994 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0    0.0033       7.4       1      17 [.       3      19 ..       3      25 .. 0.79
   2 !    7.4   0.0    0.0037       8.4       1      19 [.      27      45 ..      27      49 .. 0.78
   3 !    7.7   0.0    0.0028       6.4       1      14 [.      51      64 ..      51      73 .. 0.78
   4 ?    0.9   0.0      0.49   1.1e+03       1      13 [.      75      87 ..      75      97 .. 0.72
   5 !    6.2   0.0    0.0089        20       1      18 [.      99     116 ..      99     121 .. 0.76
   6 !    8.2   0.1     0.002       4.6       1      16 [.     123     138 ..     123     150 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0033
       LRR_1  1 nLrhLdLsnnpllglpp 17
                +L++L++++n++++ + 
  EFC35510.1  3 QLTSLNINYNNIGDEGV 19
                599********976655 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0037
       LRR_1  1 nLrhLdLsnnpllglppns 19
                +L++L++++n+++  ++ +
  EFC35510.1 27 QLTSLNINYNNIGVEGAKY 45
                599********97666655 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0028
       LRR_1  1 nLrhLdLsnnpllg 14
                +L++Ld+s+n+++ 
  EFC35510.1 51 QLTSLDISDNNIGV 64
                599*******9954 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.49
       LRR_1  1 nLrhLdLsnnpll 13
                +L++L+++ n ++
  EFC35510.1 75 QLTSLNIRINEIG 87
                599***9877665 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.0089
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld++ n+++  ++ 
  EFC35510.1  99 QLTSLDINCNNIGVEGAK 116
                 599****99999766655 PP

  == domain 6  score: 8.2 bits;  conditional E-value: 0.002
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++Ld+s+n+++  +
  EFC35510.1 123 QLTSLDISDNNIGVEG 138
                 599********95444 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.4     0.023        51      63     116 ..       1      53 [.       1      55 [. 0.70
   2 !   17.5   0.4     1e-06    0.0023      41     125 ..      49     134 ..      44     140 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.023
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkle 116
                 +k+l +l +n n i   + +l   + +l++l ++ n++   +  + + ++k+l+
  EFC35510.1   1 MKQLTSLNINYNNIGDEGVKLISEMKQLTSLNINYNNIGVEGA-KYISEMKQLT 53 
                 5778888888888888888888888888888888888764443.5555555555 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 1e-06
       LRR_9  41 ldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelv...ltnnelqeladldPlaslkklellsllknpv 125
                 + q+ ++d+sdn+i  ++g+ l+  +k l   n ri  i+ + ++++ ++++l    ++ n++   +  + + ++k+l++l + +n +
  EFC35510.1  49 MKQLTSLDISDNNIG-VEGVKLISEMKQLTSLNIRINEIGVEGAKYISEMKQLTsldINCNNIGVEG-AKYISEMKQLTSLDISDNNI 134
                 568999********5.9***********************999999988777652115556665444.47899999999999888876 PP

>> DUF1825  Domain of unknown function (DUF1825)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.2   0.00037      0.82      10      50 ..      15      54 ..       7      99 .. 0.73
   2 ?    1.1   0.0      0.16   3.6e+02      15      48 ..      92     124 ..      84     129 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00037
     DUF1825 10 qqeakelfqdyqeliqlgskygkfdreGkkifiekleelle 50
                 +e  +l +++++l  l  +y +   eG k +i ++ +l  
  EFC35510.1 15 GDEGVKLISEMKQLTSLNINYNNIGVEGAK-YISEMKQLTS 54
                5788899*********************87.9999999864 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.16
     DUF1825  15 elfqdyqeliqlgskygkfdreGkkifiekleel 48 
                 +  +++++l  l  +  +   eG k +i ++ +l
  EFC35510.1  92 KYISEMKQLTSLDINCNNIGVEGAK-YISEMKQL 124
                 5667888888888888888888876.78888776 PP

>> DUF2100  Uncharacterized protein conserved in archaea (DUF2100)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.2     0.029        64     123     149 ..       2      28 ..       1      42 [. 0.71
   2 ?    6.5   0.1    0.0031       6.9     120     148 ..      23      51 ..      19      54 .. 0.90
   3 ?    4.4   0.1     0.013        29     121     155 ..      48      85 ..      43      94 .. 0.74
   4 ?    5.3   0.0     0.007        16     121     148 ..      96     123 ..      91     127 .. 0.91
   5 ?    1.2   0.0      0.13   2.9e+02     121     145 ..     120     144 ..     114     148 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.029
                 HHHHHHXSSSXEEEXSSXSSSHHHHTT CS
     DUF2100 123 KaLkeinvdlniisteGvLeieDmkei 149
                 K+L  +n++ n+i  eGv  i +mk++
  EFC35510.1   2 KQLTSLNINYNNIGDEGVKLISEMKQL 28 
                 778888888888888888667777654 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0031
                 HHHHHHHHHXSSSXEEEXSSXSSSHHHHT CS
     DUF2100 120 kvlKaLkeinvdlniisteGvLeieDmke 148
                 +++K+L  +n++ n+i +eG+  i +mk+
  EFC35510.1  23 SEMKQLTSLNINYNNIGVEGAKYISEMKQ 51 
                 578******************99999997 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.013
                 HHHHHHHHXSSSXEEEXSSXSSSHHHHT...T..XXXS CS
     DUF2100 121 vlKaLkeinvdlniisteGvLeieDmke...iNPkipe 155
                 ++K+L  +++  n+i +eGv  i +mk+   +N +i+e
  EFC35510.1  48 EMKQLTSLDISDNNIGVEGVKLISEMKQltsLNIRINE 85 
                 6899999999**********777778761114555655 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.007
                 HHHHHHHHXSSSXEEEXSSXSSSHHHHT CS
     DUF2100 121 vlKaLkeinvdlniisteGvLeieDmke 148
                 ++K+L  ++++ n+i +eG+  i +mk+
  EFC35510.1  96 EMKQLTSLDINCNNIGVEGAKYISEMKQ 123
                 78******************99999997 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.13
                 HHHHHHHHXSSSXEEEXSSXSSSHH CS
     DUF2100 121 vlKaLkeinvdlniisteGvLeieD 145
                 ++K+L  +++  n+i +eGv  i D
  EFC35510.1 120 EMKQLTSLDISDNNIGVEGVRLISD 144
                 689****************955555 PP

>> Lsm_C  Lsm C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.022        49       5      44 ..       5      43 ..       1      48 [. 0.83
   2 ?    8.7   0.3   0.00065       1.5      10      44 ..      58      91 ..      46      97 .. 0.85
   3 ?   -0.0   0.1      0.35   7.8e+02      19      43 ..     115     138 ..      97     144 .. 0.59

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.022
                HHHHHHHS...TTTEEEETTTTEEEETTTEEEETTEEE-- CS
       Lsm_C  5 aelvekelnlrpglVkvieeanvvvvldrikVsekGVeGs 44
                 +l + ++n+  + Vk i+e + ++ l+ i   + GVeG+
  EFC35510.1  5 TSLNINYNNIGDEGVKLISEMKQLTSLN-INYNNIGVEGA 43
                5566778999999********9999777.99999999995 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00065
                HHS...TTTEEEETTTTEEEETTTEEEETTEEE-- CS
       Lsm_C 10 kelnlrpglVkvieeanvvvvldrikVsekGVeGs 44
                + +n+  + Vk i+e + ++ l+ i++ e GVeG+
  EFC35510.1 58 SDNNIGVEGVKLISEMKQLTSLN-IRINEIGVEGA 91
                566788889*********99887.**********6 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.35
                 EEEETTTTEEEETTTEEEETTEEE- CS
       Lsm_C  19 VkvieeanvvvvldrikVsekGVeG 43 
                  k+i+e + ++ ld i   + GVeG
  EFC35510.1 115 AKYISEMKQLTSLD-ISDNNIGVEG 138
                 45555554444444.3334456666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       401  (0.022366); expected 358.6 (0.02)
Passed bias filter:                      211  (0.0117686); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.56u 0.35s 00:00:00.91 Elapsed: 00:00:00.55
# Mc/sec: 828.25
//
Query:       EFC35511.1  [L=295]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.2e-78  250.0  19.5    3.6e-06   26.6   0.0   12.0 12  LRR_6     Leucine Rich repeat
    1.4e-33  114.4  15.3    1.9e-08   34.0   0.8    4.5  4  LRR_8     Leucine rich repeat
    1.4e-26   88.9   2.0        3.1    8.7   0.0   11.7 12  LRR_1     Leucine Rich Repeat
    1.5e-25   88.8  34.2    0.00013   22.3   1.3    7.2  9  LRR_4     Leucine Rich repeats (2 copies)
    2.9e-06   26.9   8.2     0.0065   16.0   0.3    3.8  4  LRR_9     Leucine-rich repeat
    4.8e-05   23.1   0.7         13    5.7   0.0    5.7  7  PapC_C    PapC C-terminal domain
  ------ inclusion threshold ------
      0.035   13.9   4.0        4.3    7.2   0.2    4.7  6  Lsm_C     Lsm C-terminal
       0.21   11.3   9.0        4.8    6.9   0.1    4.4  5  DUF4869   Domain of unknown function (DUF4869)
       0.24   11.3   0.5         77    3.3   0.0    4.7  6  DUF3409   Domain of unknown function (DUF3409)
       0.27   11.3   3.1         69    3.5   0.1    4.1  5  AlphaC_N  Alpha C protein N terminal
       0.46   10.7  11.1         27    5.0   0.1    4.6  5  PI_PP_I   Phosphoinositide phosphatase insertion domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.1   1.6e-08   2.7e-05       5      24 .]       4      23 ..       2      23 .. 0.93
   2 !   18.8   0.0   6.7e-07    0.0011       5      24 .]      28      47 ..      25      47 .. 0.92
   3 !   21.7   0.1   8.3e-08   0.00014       5      24 .]      52      71 ..      49      71 .. 0.92
   4 !   12.0   0.0    0.0001      0.17       5      24 .]      76      95 ..      73      95 .. 0.92
   5 !   19.7   0.0   3.6e-07   0.00059       5      24 .]     100     119 ..      97     119 .. 0.92
   6 !   22.9   0.0   3.4e-08   5.5e-05       5      24 .]     124     143 ..     121     143 .. 0.92
   7 !   22.3   0.0   5.2e-08   8.4e-05       5      24 .]     148     167 ..     145     167 .. 0.92
   8 !   21.1   0.1   1.2e-07    0.0002       5      24 .]     172     191 ..     169     191 .. 0.92
   9 !   23.9   0.0   1.6e-08   2.7e-05       5      24 .]     196     215 ..     193     215 .. 0.92
  10 !   26.6   0.0   2.2e-09   3.6e-06       5      24 .]     220     239 ..     217     239 .. 0.92
  11 !   19.9   0.0     3e-07   0.00049       5      24 .]     244     263 ..     241     263 .. 0.92
  12 !   18.8   0.1   6.9e-07    0.0011       5      24 .]     268     287 ..     265     287 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1.6e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++++N+IgDeG++ ++
  EFC35511.1  4 LTSLNINYNNIGDEGVKLIS 23
                9***************9985 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 6.7e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+++N+Ig eGa+ ++
  EFC35511.1 28 LTSLDINYNNIGVEGAKYIS 47
                9***************9885 PP

  == domain 3  score: 21.7 bits;  conditional E-value: 8.3e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+s+N+Ig eG++ ++
  EFC35511.1 52 LTSLDISDNNIGVEGVKLIS 71
                9***************9985 PP

  == domain 4  score: 12.0 bits;  conditional E-value: 0.0001
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L+++ N+Ig eGa+ ++
  EFC35511.1 76 LTSLNIRINEIGVEGAKYIS 95
                9***************9885 PP

  == domain 5  score: 19.7 bits;  conditional E-value: 3.6e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+++N+Ig eGa+ ++
  EFC35511.1 100 LTSLDINCNNIGVEGAKYIS 119
                 9***************9885 PP

  == domain 6  score: 22.9 bits;  conditional E-value: 3.4e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s+N+Ig eGa+ ++
  EFC35511.1 124 LTSLDISWNNIGVEGAKLIS 143
                 9***************9985 PP

  == domain 7  score: 22.3 bits;  conditional E-value: 5.2e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L+++ N+IgDeGa+ ++
  EFC35511.1 148 LTSLNIRRNEIGDEGAKYIS 167
                 9***************9885 PP

  == domain 8  score: 21.1 bits;  conditional E-value: 1.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s+N+Ig eGa+ ++
  EFC35511.1 172 LTSLNISDNNIGVEGAKLIS 191
                 9***************9985 PP

  == domain 9  score: 23.9 bits;  conditional E-value: 1.6e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++++N+IgDeGa+ ++
  EFC35511.1 196 LTSLNINWNEIGDEGAKYIS 215
                 9***************9885 PP

  == domain 10  score: 26.6 bits;  conditional E-value: 2.2e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s+N+IgDeGa+ ++
  EFC35511.1 220 LTSLNISWNKIGDEGAKYIS 239
                 9***************9885 PP

  == domain 11  score: 19.9 bits;  conditional E-value: 3e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+++N+Ig eGa+ ++
  EFC35511.1 244 LTSLDINWNKIGVEGAKLIS 263
                 9***************9985 PP

  == domain 12  score: 18.8 bits;  conditional E-value: 6.9e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++++N+Ig eGa+ L+
  EFC35511.1 268 LTSLNINDNNIGVEGAKYLS 287
                 9***************9885 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.0   0.8   1.1e-11   1.9e-08       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   30.2   0.0   1.7e-10   2.7e-07       2      61 .]      75     134 ..      74     134 .. 0.98
   3 !   32.4   0.3   3.5e-11   5.6e-08       2      61 .]     147     206 ..     142     206 .. 0.98
   4 !   26.1   0.5   3.3e-09   5.4e-06       2      61 .]     219     278 ..     218     278 .. 0.98

  Alignments for each domain:
  == domain 1  score: 34.0 bits;  conditional E-value: 1.1e-11
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsL+++ N++ + + +  + +++L++Ld+++N++ +  ++ +s +++L+sLd+s+N++
  EFC35511.1  3 QLTSLNINYNNIGDEGVKLISEMKQLTSLDINYNNIGVEGAKYISEMKQLTSLDISDNNI 62
                7*********************************************************97 PP

  == domain 2  score: 30.2 bits;  conditional E-value: 1.7e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL+++ N + + + +  + +++L++Ld+++N++ +  ++ +s +++L+sLd+s+N++
  EFC35511.1  75 QLTSLNIRINEIGVEGAKYISEMKQLTSLDINCNNIGVEGAKYISEMKQLTSLDISWNNI 134
                 7*********************************************************97 PP

  == domain 3  score: 32.4 bits;  conditional E-value: 3.5e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++++N + + + +  + +++L++L++s+N++ +  ++ +s +++L+sL++++N +
  EFC35511.1 147 QLTSLNIRRNEIGDEGAKYISEMKQLTSLNISDNNIGVEGAKLISEMKQLTSLNINWNEI 206
                 7*********************************************************86 PP

  == domain 4  score: 26.1 bits;  conditional E-value: 3.3e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++s N++ + + +  + +++L++Ld++ N++ +  ++ +s +++L+sL++++N++
  EFC35511.1 219 QLTSLNISWNKIGDEGAKYISEMKQLTSLDINWNKIGVEGAKLISEMKQLTSLNINDNNI 278
                 7*********************************************************97 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.0     0.011        18       1      16 [.       3      18 ..       3      25 .. 0.79
   2 ?    6.3   0.0     0.011        19       1      19 [.      27      45 ..      27      49 .. 0.78
   3 !    6.5   0.0    0.0097        16       1      14 [.      51      64 ..      51      73 .. 0.78
   4 ?   -0.4   0.0       1.9   3.1e+03       2      12 ..      76      86 ..      75      96 .. 0.73
   5 ?    5.0   0.0     0.031        50       1      18 [.      99     116 ..      99     121 .. 0.76
   6 !    8.4   0.0    0.0024       3.8       1      15 [.     123     137 ..     123     145 .. 0.78
   7 ?    6.0   0.0     0.015        25       1      20 [.     147     166 ..     147     169 .. 0.82
   8 ?    6.5   0.0      0.01        16       1      15 [.     171     185 ..     171     193 .. 0.78
   9 !    7.7   0.0     0.004       6.6       1      20 [.     195     214 ..     195     217 .. 0.82
  10 !    8.7   0.0    0.0019       3.1       1      20 [.     219     238 ..     219     241 .. 0.82
  11 !    6.6   0.0    0.0092        15       1      15 [.     243     257 ..     243     265 .. 0.78
  12 ?    6.1   0.0     0.014        23       1      19 [.     267     285 ..     267     289 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.011
       LRR_1  1 nLrhLdLsnnpllglp 16
                +L++L++++n++++ +
  EFC35511.1  3 QLTSLNINYNNIGDEG 18
                599********97665 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.011
       LRR_1  1 nLrhLdLsnnpllglppns 19
                +L++Ld+++n+++  ++ +
  EFC35511.1 27 QLTSLDINYNNIGVEGAKY 45
                599********97666655 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0097
       LRR_1  1 nLrhLdLsnnpllg 14
                +L++Ld+s+n+++ 
  EFC35511.1 51 QLTSLDISDNNIGV 64
                599*******9854 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 1.9
       LRR_1  2 LrhLdLsnnpl 12
                L++L+++ n +
  EFC35511.1 76 LTSLNIRINEI 86
                99***976665 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.031
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld++ n+++  ++ 
  EFC35511.1  99 QLTSLDINCNNIGVEGAK 116
                 599****99998766655 PP

  == domain 6  score: 8.4 bits;  conditional E-value: 0.0024
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++Ld+s+n+++  
  EFC35511.1 123 QLTSLDISWNNIGVE 137
                 599********9654 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n +++ ++ ++
  EFC35511.1 147 QLTSLNIRRNEIGDEGAKYI 166
                 599********988877766 PP

  == domain 8  score: 6.5 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L++s+n+++  
  EFC35511.1 171 QLTSLNISDNNIGVE 185
                 599*******99654 PP

  == domain 9  score: 7.7 bits;  conditional E-value: 0.004
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n +++ ++ ++
  EFC35511.1 195 QLTSLNINWNEIGDEGAKYI 214
                 599********988877766 PP

  == domain 10  score: 8.7 bits;  conditional E-value: 0.0019
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++s+n +++ ++ ++
  EFC35511.1 219 QLTSLNISWNKIGDEGAKYI 238
                 599********988877766 PP

  == domain 11  score: 6.6 bits;  conditional E-value: 0.0092
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++Ld+++n ++  
  EFC35511.1 243 QLTSLDINWNKIGVE 257
                 599*******98554 PP

  == domain 12  score: 6.1 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L++++n+++  ++ +
  EFC35511.1 267 QLTSLNINDNNIGVEGAKY 285
                 599********97666655 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   1.3   7.7e-08   0.00013       1      34 [.       2      37 ..       2      41 .. 0.88
   2 !   19.5   0.3   6.1e-07   0.00099       1      36 [.      50      86 ..      50      93 .. 0.81
   3 !    8.2   0.2    0.0022       3.5      21      36 ..      96     110 ..      84     114 .. 0.74
   4 !   17.0   0.5   3.6e-06    0.0059       1      33 [.      98     133 ..      98     138 .. 0.81
   5 !   16.2   0.2   6.3e-06      0.01       1      37 [.     122     159 ..     122     163 .. 0.75
   6 !   18.9   1.1   9.2e-07    0.0015       1      36 [.     170     206 ..     170     211 .. 0.80
   7 !   11.7   0.4   0.00017      0.28       1      37 [.     194     231 ..     194     235 .. 0.81
   8 !   14.6   0.1   2.1e-05     0.034       1      35 [.     218     253 ..     218     258 .. 0.81
   9 !   15.8   2.2   8.8e-06     0.014       1      34 [.     242     277 ..     242     282 .. 0.82

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 7.7e-08
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNn 34
                ++L++L+++ N++ d +  l + +++L++Ld++ Nn
  EFC35511.1  2 KQLTSLNINYNNIGDEGVkLISeMKQLTSLDINYNN 37
                58*************99996655*********8884 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 6.1e-07
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36
                ++L++Ld+s+N++   +  l + +++L++L++ + n i
  EFC35511.1 50 KQLTSLDISDNNIGVEGVkLISeMKQLTSLNI-RINEI 86
                58**********99666686655********9.64444 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0022
                 H-TT--EEE-.-S--- CS
       LRR_4  21 klpnLkeLdLsgNnli 36 
                  +++L++Ld+ ++n+i
  EFC35511.1  96 EMKQLTSLDI-NCNNI 110
                 4999*****9.65565 PP

  == domain 4  score: 17.0 bits;  conditional E-value: 3.6e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-..-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdL.sgN 33 
                 ++L++Ld++ N++   +   ++ +++L++Ld+ ++N
  EFC35511.1  98 KQLTSLDINCNNIGVEGAkyISEMKQLTSLDIsWNN 133
                 58*******99999766675445*********6665 PP

  == domain 5  score: 16.2 bits;  conditional E-value: 6.3e-06
                 SS--EEE--.SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLs.nNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++Ld+s n ++   +   ++ +++L++L++ +N  i+
  EFC35511.1 122 KQLTSLDISwN-NIGVEGAklISEMKQLTSLNIRRN-EIG 159
                 58*******88.666444462445*********667.665 PP

  == domain 6  score: 18.9 bits;  conditional E-value: 9.2e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-.S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsg.Nnli 36 
                 ++L++L++s+N++   +  l + +++L++L++ + N  i
  EFC35511.1 170 KQLTSLNISDNNIGVEGAkLISeMKQLTSLNI-NwN-EI 206
                 58************766696655*********.434.44 PP

  == domain 7  score: 11.7 bits;  conditional E-value: 0.00017
                 SS--EEE--.SS---E-S-..HHH-TT--EEE-.-.S---- CS
       LRR_4   1 pnLevLdLs.nNqltdipl..leklpnLkeLdLsg.Nnlit 37 
                 ++L++L+++ n  + d +   ++ +++L++L++ + N +i+
  EFC35511.1 194 KQLTSLNINwN-EIGDEGAkyISEMKQLTSLNI-SwN-KIG 231
                 58*******77.****99986445*********.436.665 PP

  == domain 8  score: 14.6 bits;  conditional E-value: 2.1e-05
                 SS--EEE--.SS---E-S-..HHH-TT--EEE-.-.S-- CS
       LRR_4   1 pnLevLdLs.nNqltdipl..leklpnLkeLdLsg.Nnl 35 
                 ++L++L++s n ++ d +   ++ +++L++Ld+ + N +
  EFC35511.1 218 KQLTSLNISwN-KIGDEGAkyISEMKQLTSLDI-NwN-K 253
                 58*******77.****99986445*********.434.4 PP

  == domain 9  score: 15.8 bits;  conditional E-value: 8.8e-06
                 SS--EEE--.SS---E-S-.HHH.-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLs.nNqltdipl.lek.lpnLkeLdLsgNn 34 
                 ++L++Ld++ n ++   +  l + +++L++L++++Nn
  EFC35511.1 242 KQLTSLDINwN-KIGVEGAkLISeMKQLTSLNINDNN 277
                 58*******77.***766686655*********8884 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1      0.14   2.3e+02      63     115 ..       1      52 [.       1      55 [. 0.66
   2 !   16.0   0.3     4e-06    0.0065      41     148 ..      49     154 ..      42     160 .. 0.74
   3 !   12.1   0.6   6.4e-05       0.1      40     123 ..     168     252 ..     138     274 .. 0.54
   4 !    5.1   0.1    0.0088        14      45     101 ..     221     279 ..     215     293 .. 0.63

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.14
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkl 115
                 +k+l +l +n n i   + +l   + +l++l ++ n++   +  + + ++k+l
  EFC35511.1   1 MKQLTSLNINYNNIGDEGVKLISEMKQLTSLDINYNNIGVEGA-KYISEMKQL 52 
                 5677888888888888888888888888888887777754333.445555555 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 4e-06
       LRR_9  41 ldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelv...ltnnelqeladldPlaslkklellsllknpvtnkkeyrlyvi 136
                 + q+ ++d+sdn+i  ++g+ l+  +k l   n ri  i+ + ++++ ++++l    ++ n++   +  + + ++k+l++l +  n +  +      +i
  EFC35511.1  49 MKQLTSLDISDNNIG-VEGVKLISEMKQLTSLNIRINEIGVEGAKYISEMKQLTsldINCNNIGVEG-AKYISEMKQLTSLDISWNNIGVE---GAKLI 142
                 568999********5.9***********************999999988877752114555554333.36777788888777766665443...34566 PP

       LRR_9 137 yklkqlrlldfr 148
                   +kql+ l+ r
  EFC35511.1 143 SEMKQLTSLNIR 154
                 666666666655 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 6.4e-05
       LRR_9  40 tldqfdtidlsdndirkldgfPl...lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                  + q+ ++++sdn+i  ++g  l   +k+l +l +n n i   + +    + +l++l ++ n++ + +  + + ++k+l++l +  n
  EFC35511.1 168 EMKQLTSLNISDNNIG-VEGAKLiseMKQLTSLNINWNEIGDEGAKYISEMKQLTSLNISWNKIGDEGA-KYISEMKQLTSLDINWN 252
                 3456677777777763.4444441114444455555555555555555555555555556666665554.56666666666655544 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0088
       LRR_9  45 dtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelq 101
                  ++++s n+i +     +  +k+l +l +n n+i   + +l   + +l++l +++n++ 
  EFC35511.1 221 TSLNISWNKIGDegAKYISEMKQLTSLDINWNKIGVEGAKLISEMKQLTSLNINDNNIG 279
                 45555555554311223445667777777888887777777777777777777777764 PP

>> PapC_C  PapC C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0         2   3.3e+03      29      50 ..      14      35 ..       8      39 .. 0.82
   2 ?   -1.9   0.0       1.8     3e+03      29      50 ..      38      59 ..      32      61 .. 0.81
   3 ?    3.4   0.0     0.042        69      29      52 ..     110     133 ..      99     135 .. 0.90
   4 ?    0.8   0.0      0.28   4.5e+02      29      50 ..     158     179 ..     152     182 .. 0.88
   5 ?   -0.3   0.0      0.61   9.9e+02      30      52 ..     183     205 ..     173     209 .. 0.84
   6 !    5.7   0.0    0.0081        13      29      51 ..     206     228 ..     186     230 .. 0.90
   7 ?    5.1   0.0     0.012        20      29      52 ..     230     253 ..     229     255 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2
                B-CCCEEEEECE-SEEEEEEES CS
      PapC_C 29 VgqgGqvylrglpdqgtLtvkw 50
                +g++G   ++ +++  +L+++ 
  EFC35511.1 14 IGDEGVKLISEMKQLTSLDINY 35
                7999999999999999998865 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.8
                B-CCCEEEEECE-SEEEEEEES CS
      PapC_C 29 VgqgGqvylrglpdqgtLtvkw 50
                +g +G  y++ +++  +L+++ 
  EFC35511.1 38 IGVEGAKYISEMKQLTSLDISD 59
                577899999*999999998875 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.042
                 B-CCCEEEEECE-SEEEEEEES-S CS
      PapC_C  29 VgqgGqvylrglpdqgtLtvkwge 52 
                 +g +G  y++ +++  +L+++w++
  EFC35511.1 110 IGVEGAKYISEMKQLTSLDISWNN 133
                 6778999***************87 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.28
                 B-CCCEEEEECE-SEEEEEEES CS
      PapC_C  29 VgqgGqvylrglpdqgtLtvkw 50 
                 +g++G  y++ +++  +L+++ 
  EFC35511.1 158 IGDEGAKYISEMKQLTSLNISD 179
                 79************99999876 PP

  == domain 5  score: -0.3 bits;  conditional E-value: 0.61
                 -CCCEEEEECE-SEEEEEEES-S CS
      PapC_C  30 gqgGqvylrglpdqgtLtvkwge 52 
                 g +G   ++ +++  +L+++w+e
  EFC35511.1 183 GVEGAKLISEMKQLTSLNINWNE 205
                 66777889999**********86 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.0081
                 B-CCCEEEEECE-SEEEEEEES- CS
      PapC_C  29 VgqgGqvylrglpdqgtLtvkwg 51 
                 +g++G  y++ +++  +L+++w+
  EFC35511.1 206 IGDEGAKYISEMKQLTSLNISWN 228
                 79********************8 PP

  == domain 7  score: 5.1 bits;  conditional E-value: 0.012
                 B-CCCEEEEECE-SEEEEEEES-S CS
      PapC_C  29 VgqgGqvylrglpdqgtLtvkwge 52 
                 +g++G  y++ +++  +L+++w++
  EFC35511.1 230 IGDEGAKYISEMKQLTSLDINWNK 253
                 69********************85 PP

>> Lsm_C  Lsm C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.074   1.2e+02       6      44 ..       6      43 ..       1      49 [. 0.84
   2 ?    7.2   0.2    0.0026       4.3      11      44 ..      59      91 ..      49      97 .. 0.84
   3 ?   -1.6   0.0       1.5   2.4e+03      20      44 ..      92     115 ..      91     120 .. 0.72
   4 ?   -1.2   0.0       1.1   1.7e+03      19      43 ..     115     138 ..      98     144 .. 0.62
   5 ?   -0.4   0.0      0.63     1e+03       8      44 ..     152     187 ..     145     192 .. 0.68
   6 ?    0.2   0.0       0.4   6.5e+02      12      44 ..     228     259 ..     217     265 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.074
                HHHHHHS...TTTEEEETTTTEEEETTTEEEETTEEE-- CS
       Lsm_C  6 elvekelnlrpglVkvieeanvvvvldrikVsekGVeGs 44
                +l + ++n+  + Vk i+e + ++ ld i   + GVeG+
  EFC35511.1  6 SLNINYNNIGDEGVKLISEMKQLTSLD-INYNNIGVEGA 43
                566778999999********9999988.99999999995 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0026
                HS...TTTEEEETTTTEEEETTTEEEETTEEE-- CS
       Lsm_C 11 elnlrpglVkvieeanvvvvldrikVsekGVeGs 44
                 +n+  + Vk i+e + ++ l+ i++ e GVeG+
  EFC35511.1 59 DNNIGVEGVKLISEMKQLTSLN-IRINEIGVEGA 91
                567788889*******999887.**********6 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 1.5
                 EEETTTTEEEETTTEEEETTEEE-- CS
       Lsm_C  20 kvieeanvvvvldrikVsekGVeGs 44 
                 k+i+e + ++ ld i   + GVeG+
  EFC35511.1  92 KYISEMKQLTSLD-INCNNIGVEGA 115
                 6666666666666.77788899995 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 1.1
                 EEEETTTTEEEETTTEEEETTEEE- CS
       Lsm_C  19 VkvieeanvvvvldrikVsekGVeG 43 
                  k+i+e + ++ ld i   + GVeG
  EFC35511.1 115 AKYISEMKQLTSLD-ISWNNIGVEG 138
                 45555555555444.5555566666 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.63
                 HHHHS...TTTEEEETTTTEEEETTTEEEETTEEE-- CS
       Lsm_C   8 vekelnlrpglVkvieeanvvvvldrikVsekGVeGs 44 
                  ++ +++  +  k+i+e + ++ l+ i   + GVeG+
  EFC35511.1 152 NIRRNEIGDEGAKYISEMKQLTSLN-ISDNNIGVEGA 187
                 5566667777778888887776555.65666788885 PP

  == domain 6  score: 0.2 bits;  conditional E-value: 0.4
                 S...TTTEEEETTTTEEEETTTEEEETTEEE-- CS
       Lsm_C  12 lnlrpglVkvieeanvvvvldrikVsekGVeGs 44 
                 +++  +  k+i+e + ++ ld i   + GVeG+
  EFC35511.1 228 NKIGDEGAKYISEMKQLTSLD-INWNKIGVEGA 259
                 566677789999998888887.88899999996 PP

>> DUF4869  Domain of unknown function (DUF4869)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.13   2.2e+02      71     102 ..       9      40 ..       1      61 [. 0.70
   2 ?    2.9   0.3     0.051        83      56     101 ..      66     111 ..      55     129 .. 0.82
   3 ?    1.7   0.0      0.12     2e+02      62      97 ..     144     179 ..     128     190 .. 0.73
   4 ?    6.9   0.1     0.003       4.8      56     106 ..     186     236 ..     176     249 .. 0.82
   5 ?    5.0   0.1     0.011        19      63      97 ..     217     251 ..     201     285 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.13
     DUF4869  71 fnvsacGdnCakwlleiakkkdltinlrhimd 102
                 +n  ++Gd  +k++ e+ + + l in ++i  
  EFC35511.1   9 INYNNIGDEGVKLISEMKQLTSLDINYNNIGV 40 
                 56677888888888888888888877777644 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.051
     DUF4869  56 GvktLlllanedekifnvsacGdnCakwlleiakkkdltinlrhim 101
                 Gvk +  +++  +  + + ++G   ak++ e+ + + l in ++i 
  EFC35511.1  66 GVKLISEMKQLTSLNIRINEIGVEGAKYISEMKQLTSLDINCNNIG 111
                 77877778888888899999999*********99999999999875 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.12
     DUF4869  62 llanedekifnvsacGdnCakwlleiakkkdltinl 97 
                  +++  +  +   ++Gd  ak++ e+ + + l i+ 
  EFC35511.1 144 EMKQLTSLNIRRNEIGDEGAKYISEMKQLTSLNISD 179
                 444445555566789********9999988888865 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.003
     DUF4869  56 GvktLlllanedekifnvsacGdnCakwlleiakkkdltinlrhimdfgek 106
                 G+k +  +++  +  +n  ++Gd  ak++ e+ + + l i+ ++i d g k
  EFC35511.1 186 GAKLISEMKQLTSLNINWNEIGDEGAKYISEMKQLTSLNISWNKIGDEGAK 236
                 6666666777777889999*********************99999888755 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.011
     DUF4869  63 lanedekifnvsacGdnCakwlleiakkkdltinl 97 
                 +++  +  +   ++Gd  ak++ e+ + + l in 
  EFC35511.1 217 MKQLTSLNISWNKIGDEGAKYISEMKQLTSLDINW 251
                 33333333333455666666666665555555555 PP

>> DUF3409  Domain of unknown function (DUF3409)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.92   1.5e+03      40      49 ..      38      47 ..      36      54 .. 0.78
   2 ?    0.3   0.0      0.42   6.8e+02      37      47 ..      59      69 ..      56      77 .. 0.83
   3 ?   -1.1   0.0       1.1   1.8e+03      40      48 ..      86      94 ..      84     101 .. 0.78
   4 ?   -0.9   0.0         1   1.6e+03      40      48 ..     110     118 ..     108     125 .. 0.78
   5 ?   -3.4   0.0         6   9.8e+03      37      46 ..     179     188 ..     178     191 .. 0.82
   6 ?    3.3   0.0     0.047        77      37      55 ..     275     293 ..     265     294 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.92
     DUF3409 40 ivveGvkyqv 49
                i veG ky  
  EFC35511.1 38 IGVEGAKYIS 47
                78******65 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.42
     DUF3409 37 dativveGvky 47
                d  i veGvk 
  EFC35511.1 59 DNNIGVEGVKL 69
                78899****96 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 1.1
     DUF3409 40 ivveGvkyq 48
                i veG ky 
  EFC35511.1 86 IGVEGAKYI 94
                789*****6 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 1
     DUF3409  40 ivveGvkyq 48 
                 i veG ky 
  EFC35511.1 110 IGVEGAKYI 118
                 78******6 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 6
     DUF3409  37 dativveGvk 46 
                 d  i veG k
  EFC35511.1 179 DNNIGVEGAK 188
                 7789999988 PP

  == domain 6  score: 3.3 bits;  conditional E-value: 0.047
     DUF3409  37 dativveGvkyqvrkkGkt 55 
                 d  i veG ky    k kt
  EFC35511.1 275 DNNIGVEGAKYLSEMKRKT 293
                 88999******98888887 PP

>> AlphaC_N  Alpha C protein N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.1     0.043        69      64     100 ..      22      58 ..       4      64 .. 0.86
   2 ?    0.6   0.0      0.35   5.8e+02      58     100 ..      91     130 ..      68     136 .. 0.73
   3 ?   -1.5   0.0       1.5   2.5e+03      71     100 ..     149     178 ..     135     185 .. 0.69
   4 ?    2.8   0.0      0.07   1.1e+02      65     101 ..     191     227 ..     181     230 .. 0.89
   5 ?    0.0   0.0      0.53   8.6e+02      64      99 ..     238     273 ..     228     276 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.043
    AlphaC_N  64 aseltivgaakinyrvlksdgsdhiksdgqldivnvs 100
                  se++   + +iny+    +g+++i    ql ++++s
  EFC35511.1  22 ISEMKQLTSLDINYNNIGVEGAKYISEMKQLTSLDIS 58 
                 6899999999****************99999999988 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.35
    AlphaC_N  58 skvyaqaseltivgaakinyrvlksdgsdhiksdgqldivnvs 100
                 +k+    se++   + +in +    +g+++i    ql ++++s
  EFC35511.1  91 AKY---ISEMKQLTSLDINCNNIGVEGAKYISEMKQLTSLDIS 130
                 444...3666666677888888888888888888888888887 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1.5
    AlphaC_N  71 gaakinyrvlksdgsdhiksdgqldivnvs 100
                  + +i  +    +g+++i    ql ++n+s
  EFC35511.1 149 TSLNIRRNEIGDEGAKYISEMKQLTSLNIS 178
                 444455555556777888888888888887 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.07
    AlphaC_N  65 seltivgaakinyrvlksdgsdhiksdgqldivnvsl 101
                 se++   + +in++    +g+++i    ql ++n+s 
  EFC35511.1 191 SEMKQLTSLNINWNEIGDEGAKYISEMKQLTSLNISW 227
                 7888889999*************************95 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.53
    AlphaC_N  64 aseltivgaakinyrvlksdgsdhiksdgqldivnv 99 
                  se++   + +in++    +g++ i    ql ++n+
  EFC35511.1 238 ISEMKQLTSLDINWNKIGVEGAKLISEMKQLTSLNI 273
                 478888888999999999999999999999999998 PP

>> PI_PP_I  Phosphoinositide phosphatase insertion domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1      0.34   5.5e+02      32      59 ..       3      30 ..       1      38 [. 0.83
   2 ?    4.4   0.1     0.026        43      28      58 ..     119     149 ..      92     154 .. 0.82
   3 ?    4.2   0.4     0.029        48      28      58 ..     191     221 ..     164     229 .. 0.77
   4 ?    2.3   0.1      0.11   1.9e+02      30      58 ..     217     245 ..     209     248 .. 0.84
   5 ?    5.0   0.1     0.016        27      30      58 ..     241     269 ..     230     276 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.34
                HHHHHHHHHHHHHHH-SSHHHHHHHHHC CS
     PI_PP_I 32 dlnqfllkWeeikktslsLeedLnkian 59
                +l ++ +++++i +++++L ++++++++
  EFC35511.1  3 QLTSLNINYNNIGDEGVKLISEMKQLTS 30
                678899999*************999876 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.026
                 HHHHHHHHHHHHHHHHHHH-SSHHHHHHHHH CS
     PI_PP_I  28 klkqdlnqfllkWeeikktslsLeedLnkia 58 
                 + +++l ++ ++W++i  ++ +L +++++++
  EFC35511.1 119 SEMKQLTSLDISWNNIGVEGAKLISEMKQLT 149
                 446789999*****************99976 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.029
                 HHHHHHHHHHHHHHHHHHH-SSHHHHHHHHH CS
     PI_PP_I  28 klkqdlnqfllkWeeikktslsLeedLnkia 58 
                 + +++l ++ ++W+ei +++ +  +++++++
  EFC35511.1 191 SEMKQLTSLNINWNEIGDEGAKYISEMKQLT 221
                 44567888999*********99999999876 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.11
                 HHHHHHHHHHHHHHHHH-SSHHHHHHHHH CS
     PI_PP_I  30 kqdlnqfllkWeeikktslsLeedLnkia 58 
                 +++l ++ ++W++i +++ +  +++++++
  EFC35511.1 217 MKQLTSLNISWNKIGDEGAKYISEMKQLT 245
                 46788999**********99999999875 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.016
                 HHHHHHHHHHHHHHHHH-SSHHHHHHHHH CS
     PI_PP_I  30 kqdlnqfllkWeeikktslsLeedLnkia 58 
                 +++l ++ ++W++i  ++ +L +++++++
  EFC35511.1 241 MKQLTSLDINWNKIGVEGAKLISEMKQLT 269
                 5678999*****************99976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       336  (0.0187406); expected 358.6 (0.02)
Passed bias filter:                      156  (0.00870099); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 1694.54
//
Query:       EFC35512.1  [L=142]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   12.5   0.0        0.2   11.9   0.0    1.2  1  DUF3784   Domain of unknown function (DUF3784)


Domain annotation for each model (and alignments):
>> DUF3784  Domain of unknown function (DUF3784)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   1.1e-05       0.2      29      56 ..     101     128 ..      98     140 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.1e-05
     DUF3784  29 mskeekekydekklsrfmgivllligil 56 
                  s+eek+ y+  +l+ f+ + ++++g +
  EFC35512.1 101 FSEEEKKIYNDFALCAFYLKTCVCTGFA 128
                 69***********************943 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (142 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       373  (0.0208043); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.28s 00:00:00.72 Elapsed: 00:00:00.47
# Mc/sec: 910.61
//
Query:       EFC35513.1  [L=206]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.3e-17   61.9  60.2    2.8e-06   27.6   8.4    4.6  4  EGF_2         EGF-like domain
      6e-05   23.3  48.1     0.0059   16.9   2.4    5.3  5  EGF           EGF-like domain
  ------ inclusion threshold ------
      0.014   16.0   2.5      0.014   16.0   2.5    6.4  8  hEGF          Human growth factor-like EGF
      0.032   14.4  54.7       0.66   10.2   8.4    4.4  4  Laminin_EGF   Laminin EGF domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   8.4   6.3e-10   2.8e-06       4      32 .]      27      55 ..      25      55 .. 0.90
   2 !   17.4   9.3   9.8e-07    0.0044       6      32 .]      69      94 ..      64      94 .. 0.85
   3 !   13.2   6.7     2e-05     0.088       6      32 .]     109     134 ..     105     134 .. 0.87
   4 !   22.0  11.7   3.4e-08   0.00015       4      32 .]     146     172 ..     143     172 .. 0.91

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 6.3e-10
       EGF_2  4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32
                + ++ C+ hGtC +++ +C+C+sgy+G +C
  EFC35513.1 27 NnSSVCSRHGTCKSLN-VCECKSGYTGSDC 55
                34789*******9888.************* PP

  == domain 2  score: 17.4 bits;  conditional E-value: 9.8e-07
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                + C+ +G C n    C+C +gy+G +C
  EFC35513.1 69 NSCSARGNCTNVD-TCECRAGYSGSNC 94
                57*******8555.7************ PP

  == domain 3  score: 13.2 bits;  conditional E-value: 2e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G C +++  C+C s+  G  C
  EFC35513.1 109 VVCSGNGNCTAPN-ICSCASHAEGSWC 134
                 57********999.****999999877 PP

  == domain 4  score: 22.0 bits;  conditional E-value: 3.4e-08
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+ghG Cv   G C+C  gy+Gk C
  EFC35513.1 146 NNTVCNGHGNCV--SGACSCAVGYFGKGC 172
                 4899********..*************** PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   2.4   1.3e-06    0.0059       4      31 ..      27      53 ..      24      54 .. 0.86
   2 !   12.4   6.2   3.3e-05      0.15       4      32 .]      67      93 ..      65      93 .. 0.89
   3 ?   -1.9   0.8      0.98   4.4e+03       1       7 [.      94     100 ..      94     101 .. 0.68
   4 ?    1.0   3.1      0.12   5.4e+02       6      28 ..     111     129 ..     105     132 .. 0.76
   5 !   16.5   5.4   1.8e-06    0.0079       3      31 ..     145     170 ..     143     171 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 1.3e-06
                TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF  4 np...CsngGtCvdtgrggytCiCpeGytGk 31
                n+   Cs +GtC ++      C+C++GytG+
  EFC35513.1 27 NNssvCSRHGTCKSLN----VCECKSGYTGS 53
                45777*******8888....9*********7 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 3.3e-05
                TT..STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF  4 np..CsngGtCvdtgrggytCiCpeGytGkr 32
                np  Cs +G C ++     tC+C  Gy+G++
  EFC35513.1 67 NPnsCSARGNCTNVD----TCECRAGYSGSN 93
                7788*******9999....**********86 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.98
                 GCSTTST CS
         EGF   1 CspnpCs 7  
                 C +++C+
  EFC35513.1  94 CEQYTCN 100
                 7777884 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.12
                 STTT-EEEEETTTEEEEEECTTE CS
         EGF   6 CsngGtCvdtgrggytCiCpeGy 28 
                 Cs++G C  +     +C C+++ 
  EFC35513.1 111 CSGNGNCTAPN----ICSCASHA 129
                 *******7777....99998765 PP

  == domain 5  score: 16.5 bits;  conditional E-value: 1.8e-06
                 STT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +n+  C+++G Cv++      C C++Gy+Gk
  EFC35513.1 145 SNNtvCNGHGNCVSGA-----CSCAVGYFGK 170
                 56669***********.....*********8 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   1.6         4   1.8e+04       3       9 ..       1       7 [.       1      12 [. 0.59
   2 ?   -2.1   0.1       1.6     7e+03       3       9 ..      17      23 ..      16      28 .. 0.70
   3 ?   16.0   2.5   3.2e-06     0.014       1      22 []      32      50 ..      32      50 .. 0.93
   4 ?   -0.9   0.1      0.66     3e+03       6      13 ..      59      66 ..      55      72 .. 0.57
   5 ?    5.8   3.4     0.005        22       1      22 []      71      89 ..      65      89 .. 0.81
   6 ?   -2.7   0.6       2.5   1.1e+04       7      16 ..      94      99 ..      91     100 .. 0.65
   7 ?    1.9   7.5     0.089     4e+02       1      19 [.     111     126 ..     111     128 .. 0.89
   8 ?   10.0   8.2   0.00025       1.1       1      22 []     150     167 ..     150     167 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4
               TT-EES. CS
        hEGF 3 ngGtCid 9
               n+Gt  +
  EFC35513.1 1 NNGTNSG 7
               6668773 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.6
                TT-EES. CS
        hEGF  3 ngGtCid 9 
                n ++C++
  EFC35513.1 17 NQWSCFG 23
                7789994 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 3.2e-06
                --TT-EES..-SS..-EE--TTX CS
        hEGF  1 CnngGtCidgvgg.ykCiCpPGy 22
                C+ +GtC     + ++C+C++Gy
  EFC35513.1 32 CSRHGTCK----SlNVCECKSGY 50
                99******....669*******9 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.66
                EES..-SS CS
        hEGF  6 tCidgvgg 13
                tC++  ++
  EFC35513.1 59 TCFGVANN 66
                78844443 PP

  == domain 5  score: 5.8 bits;  conditional E-value: 0.005
                --TT-EES..-SS.-EE--TTX CS
        hEGF  1 CnngGtCidgvggykCiCpPGy 22
                C+  G C+   +  +C+C  Gy
  EFC35513.1 71 CSARGNCT---NVDTCECRAGY 89
                55567888...5578******9 PP

  == domain 6  score: -2.7 bits;  conditional E-value: 2.5
                ES..-SS.-E CS
        hEGF  7 CidgvggykC 16
                C+     y+C
  EFC35513.1 94 CE----QYTC 99
                55....5777 PP

  == domain 7  score: 1.9 bits;  conditional E-value: 0.089
                 --TT-EES..-SS.-EE-- CS
        hEGF   1 CnngGtCidgvggykCiCp 19 
                 C+++G C+     + C C+
  EFC35513.1 111 CSGNGNCT---APNICSCA 126
                 ********...667****8 PP

  == domain 8  score: 10.0 bits;  conditional E-value: 0.00025
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G C+    ++ C C+ Gy
  EFC35513.1 150 CNGHGNCV----SGACSCAVGY 167
                 ********....77*******9 PP

>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9  11.6    0.0015       6.7       3      33 ..      32      57 ..      20      71 .. 0.70
   2 ?    1.0  17.3       0.1   4.7e+02       4      36 ..      72     101 ..      59     117 .. 0.67
   3 ?    4.5   5.7    0.0088        39       4      32 ..     112     135 ..      98     137 .. 0.83
   4 ?   10.2   8.4   0.00015      0.66       3      33 ..     139     174 ..     137     175 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0015
                 CCTTTBCCSSEETTTECESBTTTEESTTS-E CS
  Laminin_EGF  3 CnphgsssssCdsstgqClCkenveGrkCdr 33
                 C+ hg    +C+s   +C+Ck +++G++C+ 
   EFC35513.1 32 CSRHG----TCKS-LNVCECKSGYTGSDCEL 57
                 44444....8887.789************95 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.1
                  CTTTBCCSSEETTTECESBTTTEESTTS-E..E-T CS
  Laminin_EGF   4 nphgsssssCdsstgqClCkenveGrkCdr..Ckp 36 
                  +     +++C +   +C+C+ +++G++C++  C+ 
   EFC35513.1  72 SA----RGNCTN-VDTCECRAGYSGSNCEQytCNG 101
                  22....235655.679*************844555 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.0088
                  CTTTBCCSSEETTTECESBTTTEESTTS- CS
  Laminin_EGF   4 nphgsssssCdsstgqClCkenveGrkCd 32 
                  +++g    +C      C+C  + eG+ Cd
   EFC35513.1 112 SGNG----NCTA-PNICSCASHAEGSWCD 135
                  4444....7877.788************9 PP

  == domain 4  score: 10.2 bits;  conditional E-value: 0.00015
                  CCTTTBCC.SSEET....TTECESBTTTEESTTS-E CS
  Laminin_EGF   3 Cnphgsss.ssCds....stgqClCkenveGrkCdr 33 
                  Cn+ +ss+ + C+     ++g+C+C  ++ G+ C++
   EFC35513.1 139 CNGISSSNnTVCNGhgncVSGACSCAVGYFGKGCEQ 174
                  88877777778888888889**************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (206 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       906  (0.0505327); expected 358.6 (0.02)
Passed bias filter:                      235  (0.0131073); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1312.36
//
Query:       EFC35514.1  [L=176]
Description: hypothetical protein NAEGRDRAFT_76832, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
        0.1   12.5   0.0       0.17   11.8   0.0    1.4  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   9.6e-06      0.17       2      37 ..      11      48 ..      10      56 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 9.6e-06
  F-box-like  2 srLPdEiLlqIFsy..LppsdLlrlalVCrrWrrvald 37
                ++LPdE+Ll I  +   +p d++  ++  +r  rv ++
  EFC35514.1 11 DQLPDELLLCIVTFstNNPIDIIKFSHINKRMERVLNS 48
                68*********976214566999999999999999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       377  (0.0210274); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1010.81
//
Query:       EFC35515.1  [L=136]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0063   16.0   0.0     0.0077   15.7   0.0    1.1  1  Peripla_BP_1    Periplasmic binding proteins and sugar bindin
  ------ inclusion threshold ------
      0.029   14.8   0.1        1.2    9.7   0.0    2.4  2  Ank             Ankyrin repeat
      0.081   13.5   0.0        1.2    9.8   0.0    2.1  2  Ank_4           Ankyrin repeats (many copies)
        0.1   12.5   0.1        2.9    7.9   0.0    2.2  2  TnpB_IS66       IS66 Orf2 like protein
       0.77    9.4   6.4       0.87    9.2   6.4    1.1  1  FAM176          FAM176 family
        1.2    7.5   8.5        1.3    7.3   8.5    1.1  1  SGT1            SGT1 protein


Domain annotation for each model (and alignments):
>> Peripla_BP_1  Periplasmic binding proteins and sugar binding domain of LacI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   2.6e-06    0.0077     126     188 ..      64     122 ..      36     125 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2.6e-06
                   EEE-TTSHHHHHHHHHHHHHHHTT-GGGEEEEE-SSSSHHHHHHHHHHHHTT-TT-SEEE-SS CS
  Peripla_BP_1 126 egpesaltakervqGflaalaeaGlevkdvhvalgsndiedaaealnelleshPeidaivain 188
                   e  ++a   ++r +G   a +e G    + +v+lg +d++++ +a++ ll+++ +++ai++ n
    EFC35515.1  64 EKGANAF-YNKRIEGVWGAYEEYGV---IHKVLLGWDDMKEQMQAIELLLSKGANVNAIYGSN 122
                   4444444.467888***********...99******************************988 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.058   1.7e+02      15      26 ..      55      68 ..      46      72 .. 0.74
   2 ?    9.7   0.0   0.00039       1.2      16      29 ..     103     117 ..      85     118 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.058
                HHHHHHHH..TTTS CS
         Ank 15 kriiklLL..hGAn 26
                 + +klLL  +GAn
  EFC35515.1 55 FNRLKLLLieKGAN 68
                45899988877998 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00039
                 HHHHHHH.TTTSTTC CS
         Ank  16 riiklLL.hGAnlna 29 
                 + i+lLL +GAn+na
  EFC35515.1 103 QAIELLLsKGANVNA 117
                 679****88*****8 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.15   4.6e+02       4      26 ..      46      68 ..      44      77 .. 0.59
   2 ?    9.8   0.0    0.0004       1.2       3      30 ..      86     118 ..      84     123 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.15
       Ank_4  4 aLhyaaisgrlelvrlLlekgad 26
                +L++a++    +l  lL+ekga+
  EFC35515.1 46 LLDSAINRDFNRLKLLLIEKGAN 68
                56666664444444566677776 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.0004
       Ank_4   3 taLhyaai.....sgrlelvrlLlekgadinaq 30 
                 +++h+        ++++++++lLl+kga++na 
  EFC35515.1  86 GVIHKVLLgwddmKEQMQAIELLLSKGANVNAI 118
                 5666666677777999***************85 PP

>> TnpB_IS66  IS66 Orf2 like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.0   0.00098       2.9      40      65 ..      51      76 ..      36      85 .. 0.92
   2 ?    2.6   0.0     0.041   1.2e+02      10      39 ..      96     125 ..      88     132 .. 0.90

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00098
   TnpB_IS66 40 rnrrrdrlKiLlwdgnGfvllykrLe 65
                +nr  +rlK+Ll ++     + kr+e
  EFC35515.1 51 INRDFNRLKLLLIEKGANAFYNKRIE 76
                699*********************98 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.041
   TnpB_IS66  10 vDmRkgidgLaalVqeelkldpfsgalFvF 39 
                  Dm+++++++  l ++  + + + g+ F+F
  EFC35515.1  96 DDMKEQMQAIELLLSKGANVNAIYGSNFIF 125
                 59***************************9 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   6.4   0.00029      0.87      52      93 ..       6      49 ..       1      76 [. 0.54

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00029
      FAM176 52 erlkkkkkklkeesekasededeeeeeeeedsseseaeeel..s 93
                ++++ ++++++ee+ +++e+e+eee +eee++ +++ ++el  s
  EFC35515.1  6 QSDQLNDQQQQEEEYNEEEEEEEEEFNEEEEEIKKTLDDELldS 49
                33333344444443333444444444455555555555554442 PP

>> SGT1  SGT1 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   8.5   0.00045       1.3     495     551 ..       4      59 ..       1      74 [. 0.70

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00045
        SGT1 495 dedssedsdeedeedeeeeeaeeeskeeekeslksYmdqmdeELaqttvgksFekkk 551
                 d ++s++ + +++++ee +e+eee++ee +e+ ++  +++d+EL  +++++ F++ k
  EFC35515.1   4 D-SQSDQLNDQQQQEEEYNEEEEEEEEEFNEEEEEIKKTLDDELLDSAINRDFNRLK 59 
                 2.223333333333344456677777777788888889***************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2451  (0.136706); expected 358.6 (0.02)
Passed bias filter:                     1128  (0.0629148); expected 358.6 (0.02)
Passed Vit filter:                       209  (0.0116571); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.38s 00:00:01.02 Elapsed: 00:00:00.55
# Mc/sec: 750.96
//
Query:       EFC35516.1  [L=456]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (456 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       555  (0.0309554); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 2627.17
//
Query:       EFC35517.1  [L=362]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-10   40.9  11.9    1.4e-06   27.7   5.7    2.3  2  ABC2_membrane_3  ABC-2 family transporter protein
    1.7e-05   25.3   0.4    1.7e-05   25.3   0.4    1.8  2  ABC_tran         ABC transporter
    0.00044   20.2   0.0     0.0032   17.4   0.0    2.2  2  Microtub_bd      Microtubule binding
     0.0044   16.3   6.5      0.016   14.5   6.9    1.7  2  ABC2_membrane_2  ABC-2 family transporter protein
  ------ inclusion threshold ------
       0.12   12.2   0.5       0.22   11.4   0.0    1.6  2  RsgA_GTPase      RsgA GTPase
       0.14   11.6   0.7        2.5    7.6   0.1    2.2  2  AAA_7            P-loop containing dynein motor region


Domain annotation for each model (and alignments):
>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.6   4.3e-07    0.0013     138     208 ..      12      86 ..       1      89 [. 0.78
   2 !   27.7   5.7   4.6e-10   1.4e-06     250     344 ..      86     218 ..      84     219 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 4.3e-07
  ABC2_membrane_3 138 atstsaninvestql....eeelsnvasflvgliliilifitasfiavsiveEkesrikelqlvsgvsplqywls 208
                         +s+++++++++     ++ +  + +   + ++ i ++i++++ ++s+v Eke +++  ++++g++ ++y++s
       EFC35517.1  12 DFRNSIKVDYKNLPQpptrKNGQVIIYNSTGPTFFSIGAMIILIVSLNSLVVEKEGKLRFAMIMMGMKDSAYFIS 86 
                      3446666777777666655777777777888899999999999999**************************997 PP

  == domain 2  score: 27.7 bits;  conditional E-value: 4.6e-10
  ABC2_membrane_3 250 layialgyllsslfknsetaqilifivilllsgffgglfp.....ledlp.....salkwifsiiPffapglgllrlitgd.plwe........ 324
                       +++++++lls+++k s++a +l f v+  ++ f+++lf+     + +l       a+++i+s+ P f +++++++++t + p ++        
       EFC35517.1  86 SCLVCFAFLLSTFIKESKSALVLGFTVL--AISFILNLFVsngniVYQLYstsvtPAFRVILSFYPPFNFAKVFTDIATKTlPVYDdqlrkfvp 177
                      58899**************997665554..566666666546666333335557799*********************8886776699999999 PP

  ABC2_membrane_3 325 .....................illsliilalfavvylllal 344
                                             l +i+l+l ++++l+l +
       EFC35517.1 178 gpgysfedffigtntydyvpaSYLGIIVLILNGLLFLILYW 218
                      9999999***********997779*************9976 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.9   5.7e+03      73      92 ..     251     277 ..     245     300 .. 0.48
   2 !   25.3   0.4   5.7e-09   1.7e-05       1      36 [.     326     361 ..     326     362 .] 0.94

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.9
                 TSBHHHH.......HHHTCHHHHHHHS CS
                 xxxxxxx.......xxxxxxxxxxxxx RF
    ABC_tran  73 eltvren.......esdeeiekalskl 92 
                 ++t+++n       +s+ e +++ +++
  EFC35517.1 251 KSTIKTNtnqdeqdYSQMETNDVKEEF 277
                 444444432222333333333333333 PP

  == domain 2  score: 25.3 bits;  conditional E-value: 5.7e-09
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllk 36 
                 lk ++l ++ +++v ++G+nGaGK++ +++l+gl k
  EFC35517.1 326 LKGLNLIVEDNQCVSLLGHNGAGKTSTMNILTGLFK 361
                 6899*****************************975 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.49   1.5e+03      61      95 ..     267     300 ..     261     306 .. 0.83
   2 !   17.4   0.0   1.1e-06    0.0032      56     101 ..     308     354 ..     304     359 .. 0.95

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.49
                  TTHCCCCCCCCHHHHHHHHTT--EEEEEEES.... CS
  Microtub_bd  61 eseqeevfeeisqlvqsaldgynvcifaygqTGsG 95 
                  + e+++v ee++   +s+++   v i+++ qT sG
   EFC35517.1 267 QMETNDVKEEFKRSRDSSINAV-VRIVSLRQTYSG 300
                  5578899999999999999865.889999998887 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 1.1e-06
                  EEEECTTHCCCCCCCCHHHHHHHH.TT--EEEEEEES.......... CS
  Microtub_bd  56 rvfeseseqeevfeeisqlvqsal.dgynvcifaygqTGsGKtyTme 101
                  ++f+++  q+ +f e ++l    l  + n c+  +g+ G+GKt Tm+
   EFC35517.1 308 KCFPAKIAQSRFFREKKALKGLNLiVEDNQCVSLLGHNGAGKTSTMN 354
                  89**********************99********************7 PP

>> ABC2_membrane_2  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.11   3.2e+02      81     103 ..      45      67 ..       3      73 .. 0.65
   2 !   14.5   6.9   5.4e-06     0.016     159     267 ..      66     203 ..      35     220 .. 0.60

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.11
  ABC2_membrane_2  81 mavlipviaalfgadaiagEker 103
                      ++ ++++i+++ + ++++ Eke 
       EFC35517.1  45 FFSIGAMIILIVSLNSLVVEKEG 67 
                      23466777888888888888886 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 5.4e-06
  ABC2_membrane_2 159 edllllvvasvll..lllv..vflalglllSsvarssreaaalalglfvvl...ailv..pivlygvaellagpavpqeindflsllsptsayn 243
                      e  l++++  + +   +++  +++ +++llS+++++s++a+ l + ++++    +++v  ++++y++ +   +    +  + +ls+++p++  +
       EFC35517.1  66 EGKLRFAMIMMGMkdSAYFisCLVCFAFLLSTFIKESKSALVLGFTVLAISfilNLFVsnGNIVYQLYSTSVT----PAFRVILSFYPPFNFAK 155
                      2222222222222111222468899**********99999998776665550003333112344445555554....55599*********999 PP

  ABC2_membrane_2 244 tllneilagsdlna........................lgstatnlli 267
                      + ++  +++ ++ +                         ++ a++l+i
       EFC35517.1 156 VFTDIATKTLPVYDdqlrkfvpgpgysfedffigtntyDYVPASYLGI 203
                      999999999888888888888887777777776665553333344444 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       1.8   5.5e+03     124     139 ..     267     282 ..     249     298 .. 0.60
   2 ?   11.4   0.0   7.3e-05      0.22      87     121 ..     323     358 ..     311     362 .] 0.83

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.8
                  ----S----------- CS
  RsgA_GTPase 124 elktgevseklgrGkh 139
                  +++t++v+e+ +r + 
   EFC35517.1 267 QMETNDVKEEFKRSRD 282
                  5566666666655554 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 7.3e-05
                  HTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCT CS
  RsgA_GTPase  87 kegleelkellkd.ktsvlvGqSGvGKStLinallp 121
                  k++l+ l+  ++d +++ l+G+ G+GK++ +n l++
   EFC35517.1 323 KKALKGLNLIVEDnQCVSLLGHNGAGKTSTMNILTG 358
                  567777777888879999**************9986 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.1     0.043   1.3e+02      20      55 ..      89     124 ..      85     138 .. 0.84
   2 ?    7.6   0.1   0.00083       2.5      26      52 ..     329     355 ..     325     361 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.043
       AAA_7  20 vrysyllelllknkkpvllvGptGtGKtviikdllk 55 
                 v++ +ll++++k++k+ l+ G t  + + i++ +++
  EFC35517.1  89 VCFAFLLSTFIKESKSALVLGFTVLAISFILNLFVS 124
                 6789*****************999998888877665 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00083
       AAA_7  26 lelllknkkpvllvGptGtGKtviikd 52 
                 l+l+++ ++ v l G+ G GKt++++ 
  EFC35517.1 329 LNLIVEDNQCVSLLGHNGAGKTSTMNI 355
                 678999*****************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       976  (0.0544369); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2086.69
//
Query:       EFC35518.1  [L=743]
Description: kinesin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   1.6e-107  359.3   0.9   1.6e-107  359.3   0.9    2.5  4  Kinesin      Kinesin motor domain
    5.6e-21   75.0   1.4    5.6e-21   75.0   1.4    3.7  2  Microtub_bd  Microtubule binding


Domain annotation for each model (and alignments):
>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   1.4       0.3   2.7e+03     194     223 ..      49      78 ..       5     128 .. 0.56
   2 !  359.3   0.9  1.8e-111  1.6e-107       1     333 []     152     485 ..     152     485 .. 0.93
   3 ?   -3.7   0.1      0.48   4.3e+03      30      49 ..     585     604 ..     564     624 .. 0.50
   4 ?   -5.0   1.7       1.2   1.1e+04      25      47 ..     672     694 ..     643     713 .. 0.48

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.3
                 STTSSCTSHHCCSEEEEEEEEEEEETTTTT CS
     Kinesin 194 vaetklneeSSRSHavftitleqknlkeet 223
                  +++++ ++  +SH+  ++  ++ n+k++t
  EFC35518.1  49 LSSSTASSNMTKSHSTSELSAQNINTKTKT 78 
                 333444444445555555444444444433 PP

  == domain 2  score: 359.3 bits;  conditional E-value: 1.8e-111
                 EE-SSSHHHHTTTTEBCEEEECTCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHTTSEEEEEEEESTTSSHHHHHTBC.... CS
     Kinesin   1 RvRplnekekeeeeeeeveveeekkeeekkskkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvleGynatifaYGqtgsGKTyTmegk.... 95 
                 RvRp  +++ ++++     +    ++ +++   +++   +++f+Fdkv++++++q+e+y+++ k++v++vl+Gyn+t++aYGqtgsGKT+T+ g+    
  EFC35518.1 152 RVRPQVSEDISNSQIFGE-YPPCVATVKNTVILKRECYDDREFTFDKVLEPTCSQDEMYKQVGKNIVNDVLKGYNGTVLAYGQTGSGKTFTIFGSstdp 249
                 778877766665555444.444667777777888888999*********************************************************** PP

                 ..........TTTSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEEEEEETTEEEETTSTTTTSTSSEBEEEECTTSCCEEETTS--EEESSHHHHHHH CS
     Kinesin  96 ..........eeeeeGiipraleelFesikkekeekekefsvkvsylEiYneeiyDLLeskkskkkkklkiredskkgevyvkgltevevksaeevlel 184
                            ++ +G+ipr+++++Fe++++ +++  +ef+v vs+++iY+e+i+DLL+ +    k++l ired+k+g v+v++lt+v+v++  ev++l
  EFC35518.1 250 kriikpneniIDKYSGVIPRCINQIFEHVQEYSNN--TEFRVFVSFMQIYMENIMDLLDAS----KTNLPIREDPKNG-VFVEQLTQVQVNEPYEVMQL 341
                 *******99977889***************99987..99********************98....456********98.******************** PP

                 HHHHHHHHTSTTSSCTSHHCCSEEEEEEEEEEEETTTTTCEEEEEEEEEEEEEEECCCHHHHSSTCHHHHHHHHHHHHHHHHHHHHHHHHHHTCCTSTS CS
     Kinesin 185 lekgeknrkvaetklneeSSRSHavftitleqknlkeeteekvkisklnLvDLAGsErasktgaaegerlkEaaniNkSLlaLgrvisaLaekkkskhi 283
                 +++g+knr+v++t++n+ SSRSH +++it+eqk+++++   +vk++ l++vDLAGsEr+ k+g +eg+rl+Ea++iNkSL+aLg++++aL+e+ +  h+
  EFC35518.1 342 IKEGSKNRQVNSTNMNKLSSRSHVILMITVEQKSSSDK---SVKRGVLHIVDLAGSERVFKSG-SEGQRLEEAKKINKSLSALGNCVAALTEE-NVYHV 435
                 *********************************96643...479*******************.58***************************.99*** PP

                 CGGGSHHHHHTGGGHSSSSEEEEEEEE-TBGGGHHHHHHHHHHHHHHCTT CS
     Kinesin 284 pYRdSkLTrlLqdsLgGnsktlmivtvspssenleetlstlkfaerakei 333
                 p+RdSkLTrlL dsLgGn+kt++++t+ ps  n++e++stl+fa+ra ++
  EFC35518.1 436 PFRDSKLTRLLTDSLGGNAKTCLVATIGPSMWNYDESYSTLHFANRAMNV 485
                 ***********************************************986 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 0.48
                 EEEEEECTTSCEEEEESEEE CS
     Kinesin  30 kskkenkeeeekkfkFdkvf 49 
                 k k++++++++++ + ++v+
  EFC35518.1 585 KAKNRQEQNNQSDESLERVI 604
                 22333333333333333333 PP

  == domain 4  score: -5.0 bits;  conditional E-value: 1.2
                 TCEEEEEEEEECTTSCEEEEESE CS
     Kinesin  25 keeekkskkenkeeeekkfkFdk 47 
                 ++ +++++ + ++++e++ +F++
  EFC35518.1 672 NSADSNDSLRYDHQQEQQEQFEQ 694
                 22222222222333333333333 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.9   5.6         2   1.8e+04      58     113 ..      59     115 ..      23     145 .. 0.65
   2 !   75.0   1.4   6.3e-25   5.6e-21      22     149 .]     147     305 ..     135     305 .. 0.80

  Alignments for each domain:
  == domain 1  score: -4.9 bits;  conditional E-value: 2
                  EECTTHCCCCCCCCHHHHHHHHTT--EEEEEEES.................ST-HCH CS
  Microtub_bd  58 feseseqeevfeeisqlvqsaldgynvcifaygqTGsGKtyTmeg.eeeeagmipra 113
                   +s+s++e  +++i+  ++  l++ n++i+    T s  t   ++ ++++++ +++a
   EFC35518.1  59 TKSHSTSELSAQNINTKTKTLLNNPNTSIIGNNPTISNNTVSNTTaNNATSTATTSA 115
                  456667778888888888888999999999888877777655444322333333333 PP

  == domain 2  score: 75.0 bits;  conditional E-value: 6.3e-25
                  -EEEEEEECCCS-T............EEEETTT.............TTTEEEE-SEEEECTTHCCCCCCCC.HHHHHHHHTT--EEEEEEES...... CS
  Microtub_bd  22 iRvfarvrpelesek...........akikfpe..........eekkkkkefsFdrvfeseseqeevfeei.sqlvqsaldgynvcifaygqTGsGKt 97 
                  + v +rvrp+ +++            +                +e   ++ef+Fd+v+e++++q+e+++++ + +v+ +l+gyn +++aygqTGsGKt
   EFC35518.1 147 VKVVVRVRPQVSEDIsnsqifgeyppC-----VatvkntvilkRECYDDREFTFDKVLEPTCSQDEMYKQVgKNIVNDVLKGYNGTVLAYGQTGSGKT 239
                  455555555555543333355555542.....03333466776778999*************99999999857899********************** PP

                  .........................ST-HCHHHHHHHHHHCCTSCCCCEEEEEEEEEEESS-EEETT CS
  Microtub_bd  98 yTmeg...............eeeeagmipraveeifetiselkekgwkyeielqfveiynekvqDlL 149
                  +T+ g                ++ +g+ipr +++ife ++e  +++ ++++ ++f++iy e++ DlL
   EFC35518.1 240 FTIFGsstdpkriikpneniIDKYSGVIPRCINQIFEHVQEY-SNNTEFRVFVSFMQIYMENIMDLL 305
                  ***9999999999988765556779****************9.79*********************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (743 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2623  (0.146299); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.94u 0.37s 00:00:01.31 Elapsed: 00:00:00.56
# Mc/sec: 3961.37
//
Query:       EFC35519.1  [L=284]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-09   37.0  19.9    3.4e-09   36.4  19.9    1.3  1  zf-C3HC4_3       Zinc finger, C3HC4 type (RING finger)
    2.1e-05   24.3  20.6    3.8e-05   23.4  20.6    1.4  1  Prok-RING_4      Prokaryotic RING finger family 4
    0.00023   20.9  22.0    0.00046   20.0  22.0    1.5  1  zf-C3HC4_2       Zinc finger, C3HC4 type (RING finger)
     0.0055   15.9   4.4     0.0078   15.4   4.4    1.3  1  Baculo_ODV-E27   Baculovirus occlusion-derived virus envelope
     0.0073   16.2  11.1      0.015   15.2  11.1    1.5  1  zf-RING_6        zf-RING of BARD1-type protein
  ------ inclusion threshold ------
      0.011   16.3   0.4      0.011   16.3   0.4    2.2  2  Ribosomal_L37    Mitochondrial ribosomal protein L37
      0.013   15.5  24.2      0.086   12.8  24.5    2.1  2  zf-RING_5        zinc-RING finger domain
      0.025   14.9  22.4      0.043   14.2  22.4    1.4  1  zf-RING_2        Ring finger domain
      0.042   13.9   3.7       0.13   12.3   0.0    3.1  1  ETRAMP           Malarial early transcribed membrane protein 
       0.06   13.4  22.5       0.46   10.6   4.9    3.4  3  DUF4558          Domain of unknown function (DUF4558)
      0.071   13.0  24.0       0.15   12.0  24.0    1.6  1  zf-C3HC4         Zinc finger, C3HC4 type (RING finger)
      0.076   13.5   0.4      0.076   13.5   0.4    2.1  2  DUF3078          Protein of unknown function (DUF3078)
       0.12   11.4   2.2       0.11   11.5   0.5    1.9  1  DUF808           Protein of unknown function (DUF808)
       0.16   11.2   6.7        0.7    9.0   1.6    2.2  2  7TM_GPCR_Srd     Serpentine type 7TM GPCR chemoreceptor Srd
       0.29   11.2  21.1      0.062   13.3  14.0    2.5  2  zf-RING_UBOX     RING-type zinc-finger
        1.3    8.3  10.5       0.52    9.7   1.3    3.2  2  CCB1             Cofactor assembly of complex C subunit B
        7.8    7.2  33.2      0.056   14.1   9.3    3.4  3  HIP1_clath_bdg   Clathrin-binding domain of Huntingtin-intera
        8.1    5.8  31.0        2.3    7.6  22.2    2.1  2  HMMR_N           Hyaluronan mediated motility receptor N-term
        8.2    5.4  15.2      0.022   13.9   1.6    2.3  2  ABC2_membrane_3  ABC-2 family transporter protein


Domain annotation for each model (and alignments):
>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.4  19.9   3.6e-12   3.4e-09       2      47 ..     235     276 ..     234     279 .. 0.92

  Alignments for each domain:
  == domain 1  score: 36.4 bits;  conditional E-value: 3.6e-12
                 GSB-TTTSSSBS-EEETTEEEEEE-HHHHHHHHHTT-B-TTT--B- CS
  zf-C3HC4_3   2 deeCviClerprnvvllpCgHlvlCeeCaekllkrkkkCpiCrrpi 47 
                 ++ C+iC++r++n+++ pCgH+ +Ce+C++++     kCpiC+++ 
  EFC35519.1 235 EQRCCICMDRNKNAAFNPCGHV-FCETCCSHC---LSKCPICKTKP 276
                 789*******************.*********...69******985 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4  20.6   4.1e-08   3.8e-05       1      39 [.     238     275 ..     238     279 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 4.1e-08
  Prok-RING_4   1 CvlCgeqekkailepCgHlvCkeCfdskdlssCPlCqrr 39 
                  C +C  ++k+a++ pCgH++C++C ++  ls CP+C+++
   EFC35519.1 238 CCICMDRNKNAAFNPCGHVFCETCCSHC-LSKCPICKTK 275
                  9************************987.666****987 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0  22.0   4.9e-07   0.00046       1      40 []     237     272 ..     237     272 .. 0.93

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 4.9e-07
  zf-C3HC4_2   1 kCpiCldmlkdpsvvtpCgHvfCqkCilrsLeekneCPlC 40 
                 +C iC+d+ k++   +pCgHvfC+ C    L   ++CP+C
  EFC35519.1 237 RCCICMDRNKNA-AFNPCGHVFCETCCSHCL---SKCPIC 272
                 6**********8.9***************86...58**99 PP

>> Baculo_ODV-E27  Baculovirus occlusion-derived virus envelope protein EC27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   4.4   8.3e-06    0.0078     172     270 ..      87     190 ..      75     223 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 8.3e-06
  Baculo_ODV-E27 172 l.dkiknvekkddlesqkiimyPfyetdeadfkitevevtqyltlllivenaylglyklkrsdvfeyfkslldhesklr..etsltkvsnll..l 261
                     l + +k  ek+++++ q+ + +   ++++ +   ++ + t y+t+l+iv  ++lg++ ++r    +  +   + e+ lr  e+   k++n l  +
      EFC35519.1  87 LtNYMKQLEKEQEYKLQQ-LKKEQDQIQLETQLANQFKNTIYMTVLVIVGGSFLGYWYIQRKLNEQIEQENKQVEQNLRtkEQEKIKIENKLieI 180
                     4467899***********.66777778888889999*********************99987666666666666655551167777888866245 PP

  Baculo_ODV-E27 262 skfkftve.k 270
                     +k k+++e k
      EFC35519.1 181 GKEKMKIEvK 190
                     7888888853 PP

>> zf-RING_6  zf-RING of BARD1-type protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2  11.1   1.6e-05     0.015       4      48 ..     232     274 ..     229     278 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.6e-05
   zf-RING_6   4 lekllrcsrctdilrepvclggcehifcsncisdcfgsgcpvcyt 48 
                 +e   rc  c d  ++   +  c h+fc  c s c+ s cp+c t
  EFC35519.1 232 IEEEQRCCICMDRNKN-AAFNPCGHVFCETCCSHCL-SKCPICKT 274
                 677789*****98765.6789**************9.78****98 PP

>> Ribosomal_L37  Mitochondrial ribosomal protein L37
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   16.3   0.4   1.2e-05     0.011      53     118 ..      91     177 ..      47     179 .. 0.80
   2 ?    1.2   2.2      0.53     5e+02      71     109 ..     198     237 ..     181     248 .. 0.50

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.2e-05
  Ribosomal_L37  53 skkarklakkklaakeaelakkipleeqsidlp.aeet.....................aeeaaeareelkkalrkkrrakIkesNfl 118
                    +k+ +k ++ kl++++ +++ +i+le q ++   ++++                     +e+ +++ ++++++lr k+++kIk +N l
     EFC35519.1  91 MKQLEKEQEYKLQQLK-KEQDQIQLETQLANQFkNTIYmtvlvivggsflgywyiqrklNEQIEQENKQVEQNLRTKEQEKIKIENKL 177
                    3333333333333333.2567899999999988777779*******************999999********************9987 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.53
  Ribosomal_L37  71 lakkipleeqsidlp.aeetaeeaaeareelkkalrkkrr 109
                    ++ + + e q+ +l   +++ e+a+ +  +lk+++ +++r
     EFC35519.1 198 QNSHQQPETQKRELErMKIELETANHELMDLKEKIEEEQR 237
                    3333334444444444444455555555555555554444 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   2.2      0.27   2.5e+02      33      42 ..     229     241 ..     221     243 .. 0.75
   2 ?   12.8  24.5   9.1e-05     0.086       2      44 .]     238     274 ..     236     274 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.27
   zf-RING_5  33 l...ekeavCpiC 42 
                 +   e+e++C+iC
  EFC35519.1 229 KekiEEEQRCCIC 241
                 2445899****** PP

  == domain 2  score: 12.8 bits;  conditional E-value: 9.1e-05
   zf-RING_5   2 CnkCfeklskeekfyltsCgHifCekClkkllekeavCpiCrk 44 
                 C +C+++   ++++ + +CgH+fCe+C++++l    +CpiC++
  EFC35519.1 238 CCICMDR---NKNAAFNPCGHVFCETCCSHCL---SKCPICKT 274
                 5555555...59999*****************...******95 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2  22.4   4.5e-05     0.043       2      44 .]     237     273 ..     236     273 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 4.5e-05
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreClerwlrssstCPlCr 44 
                  C+IC+   ++++++   pCgHvf+++C ++ l   s+CP+C+
  EFC35519.1 237 RCCICM---DRNKNAAFNPCGHVFCETCCSHCL---SKCPICK 273
                 6****8...6667788889*********99966...56****7 PP

>> ETRAMP  Malarial early transcribed membrane protein (ETRAMP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   0.00014      0.13       6      81 ..      10     147 ..       6     149 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00014
      ETRAMP   6 v.llffafLlavnlltpeslcdevnkkk.............................................................ekakkaikki 42 
                 v l+++++++++ ll+  ++cde ++k+                                                             e +++++kk 
  EFC35519.1  10 ViLFVLMMMMMMLLLITIASCDERTTKQlhdaiknnhwelinqlikggeanpyekvdywfskydafdiavyygntkfltnymkqlekeqEYKLQQLKKE 108
                 43778888888889999999999998889***********************************************************99999999999 PP

      ETRAMP  43 ddkiekkkkkkKliiistiatalallvasalGlgiykkk 81 
                 +d+i+  ++          +t+l+++ +s lG+ + + k
  EFC35519.1 109 QDQIQLETQLANQFKNTIYMTVLVIVGGSFLGYWYIQRK 147
                 999999977777666677778888999*****9987765 PP

>> DUF4558  Domain of unknown function (DUF4558)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.8   0.00058      0.55      11      50 ..      82     121 ..      77     124 .. 0.90
   2 ?    2.9   2.2      0.12   1.1e+02      57      78 ..     145     166 ..     145     173 .. 0.87
   3 ?   10.6   4.9   0.00049      0.46      20      55 ..     193     228 ..     178     237 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00058
     DUF4558  11 rekktqsralwqesleersnaralkrqqkemkeElelank 50 
                  + k+ ++ + q ++e+  + ++lk++q++++ E +lan+
  EFC35519.1  82 GNTKFLTNYMKQLEKEQEYKLQQLKKEQDQIQLETQLANQ 121
                 567888999999999************************8 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.12
     DUF4558  57 raaLkeLfekeerqyeqELnam 78 
                 + +L+e +e+e++q eq L+ +
  EFC35519.1 145 QRKLNEQIEQENKQVEQNLRTK 166
                 5689999**********99987 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00049
     DUF4558  20 lwqesleersnaralkrqqkemkeElelankellkv 55 
                 +  e+++  +++++ kr+ ++mk Ele+an el+ +
  EFC35519.1 193 EILEKQNSHQQPETQKRELERMKIELETANHELMDL 228
                 456899999999999******************975 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0  24.0   0.00016      0.15       1      41 []     238     272 ..     238     272 .. 0.99

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00016
                 -TTT-S--SS-E.E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepnelleCkHsfCskCirkilksrkkvkCPlC 41 
                 C iC++  k++  + +C+H fC++C +++l+     kCP+C
  EFC35519.1 238 CCICMDRNKNAA-FNPCGHVFCETCCSHCLS-----KCPIC 272
                 ************.******************.....9**** PP

>> DUF3078  Protein of unknown function (DUF3078)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.4     8e-05     0.076      50      84 ..      96     133 ..      71     141 .. 0.75
   2 ?   -0.9   0.1       2.5   2.4e+03      57      69 ..     165     177 ..     145     200 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 8e-05
     DUF3078  50 kdekrkl.....rkteDrlrlnsklgykaskkwyysasln 84 
                 k++  ++     +k +D+++l+++l+ ++++++y+++++ 
  EFC35519.1  96 KEQ--EYklqqlKKEQDQIQLETQLANQFKNTIYMTVLVI 133
                 333..2233555***********************99875 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 2.5
     DUF3078  57 rkteDrlrlnskl 69 
                  k ++++++++kl
  EFC35519.1 165 TKEQEKIKIENKL 177
                 3444444444444 PP

>> DUF808  Protein of unknown function (DUF808)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.5   0.00012      0.11      90     142 ..     126     178 ..     112     196 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00012
      DUF808  90 wlitplLmlGgayLcfEGae.KvlekllhkeeeeeeeeeeaeeadlaelEkekv 142
                   +t+l+++Gg +L +  ++ K+ e++  +e+++ e++ +++e+++ ++E++ +
  EFC35519.1 126 IYMTVLVIVGGSFLGYWYIQrKLNEQIE-QENKQVEQNLRTKEQEKIKIENKLI 178
                 5689999********9887526777775.5555555566666666667776665 PP

>> 7TM_GPCR_Srd  Serpentine type 7TM GPCR chemoreceptor Srd
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   1.6   0.00075       0.7     172     228 ..       3      56 ..       1      56 [. 0.88
   2 ?    4.9   0.2     0.013        12     149     223 ..      94     168 ..      75     173 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00075
  7TM_GPCR_Srd 172 dlksvaaliatliltipvvpipiiililrkkilkllksnssnmssetkaqhkqLikg 228
                   ++ ++++ i +++++++++++ i+i  + +++ k+l+     ++++  +++ qLikg
    EFC35519.1   3 KTLNLQSVILFVLMMMMMMLLLITIASCDERTTKQLHD---AIKNNHWELINQLIKG 56 
                   56788999****************************98...6788888888888886 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.013
  7TM_GPCR_Srd 149 veaetkeehpnynleeysvtGfsdlksvaaliatliltipvvpipiiililrkkilkllksnssnmssetkaqhk 223
                   +e+e+++++++ + e+ ++   ++l +    + ++++ ++v  + + ++++++k+ ++++++++++ ++ + + +
    EFC35519.1  94 LEKEQEYKLQQLKKEQDQIQLETQLANQFKNTIYMTVLVIVGGSFLGYWYIQRKLNEQIEQENKQVEQNLRTKEQ 168
                   444444444444444444544444444433333444444455678889999**********77788888776654 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3  14.0   6.5e-05     0.062       1      25 [.     238     262 ..     238     268 .. 0.83
   2 ?    1.5   0.6      0.33   3.1e+02       1       5 [.     269     273 ..     269     278 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 6.5e-05
  zf-RING_UBOX   1 CpIClelftdPlvlpCGHtFCreCl 25 
                   C IC++  ++  + pCGH+FC+ C 
    EFC35519.1 238 CCICMDRNKNAAFNPCGHVFCETCC 262
                   *********663357*********7 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.33
  zf-RING_UBOX   1 CpICl 5  
                   CpIC+
    EFC35519.1 269 CPICK 273
                   ****8 PP

>> CCB1  Cofactor assembly of complex C subunit B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   1.3   0.00055      0.52      43      95 ..      87     139 ..       6     146 .. 0.84
   2 ?    0.2   1.7      0.43     4e+02     130     166 ..     183     219 ..     178     224 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00055
        CCB1  43 lleelkeyleqraYrvaevdaeketvtfeGlvapslflAifLtllaalgllcl 95 
                 l + +k+  +++ Y+++++ +e++++++e ++a +   +i++t+l ++g   l
  EFC35519.1  87 LTNYMKQLEKEQEYKLQQLKKEQDQIQLETQLANQFKNTIYMTVLVIVGGSFL 139
                 4444555556799**********************************997655 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.43
        CCB1 130 rkeqvslkleseeeeseseitveahrdeleelqkelk 166
                  k ++++kl++  e+++s+   e ++ ele+++ el+
  EFC35519.1 183 EKMKIEVKLNEILEKQNSHQQPETQKRELERMKIELE 219
                 4557999999999999999999**********99987 PP

>> HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interacting protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   3.5       0.1        98      36      70 ..      91     118 ..      83     128 .. 0.56
   2 ?    1.5   7.4       0.5   4.7e+02      23      96 ..     150     184 ..     143     196 .. 0.55
   3 ?   14.1   9.3   5.9e-05     0.056      24      79 ..     179     236 ..     178     240 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.1
  HIP1_clath_bdg  36 lerlkeeaerkleeqkeelekLkreleakraelar 70 
                     +++l       ++eq+ +l++Lk+e  + + e + 
      EFC35519.1  91 MKQL-------EKEQEYKLQQLKKEQDQIQLETQL 118
                     3333.......445666666666665555555444 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.5
  HIP1_clath_bdg  23 eeverekkeleeelerlkeeaerkleeqkeelekLkreleakraelarlkssLesseqsgeqlssqlaaLqaEk 96 
                     e++                                       ++e +++++ L+++eq++ +++++l ++ +Ek
      EFC35519.1 150 EQI---------------------------------------EQENKQVEQNLRTKEQEKIKIENKLIEIGKEK 184
                     233.......................................45555566666666666666666666665555 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 5.9e-05
  HIP1_clath_bdg  24 everekkeleeelerl..keeaerkleeqkeelekLkreleakraelarlkssLesse 79 
                     e+ +ek ++e +l+++  k++++++ e qk ele++k ele+ ++el  lk+ +e+++
      EFC35519.1 179 EIGKEKMKIEVKLNEIleKQNSHQQPETQKRELERMKIELETANHELMDLKEKIEEEQ 236
                     567899999999999843455666777*************************999876 PP

>> HMMR_N  Hyaluronan mediated motility receptor N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   1.4     0.046        43     281     315 ..      83     117 ..      77     126 .. 0.77
   2 ?    7.6  22.2    0.0024       2.3     184     276 ..     149     237 ..     145     249 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.046
      HMMR_N 281 qvkdlnekckllekekeelvreeeekeqtlsaEle 315
                 ++k l++ +k+leke+e ++++ ++ +++++ E +
  EFC35519.1  83 NTKFLTNYMKQLEKEQEYKLQQLKKEQDQIQLETQ 117
                 67888889999999999998888887777777755 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0024
      HMMR_N 184 QedmeaklqvtqknLeeskakvaqLkeklvslekekieekseteklleyieelsnvseqlekykldiaqleellkekndeiesLkssLeekeq 276
                  e++e + +++++nL++  ++  ++++kl ++ ke    k+++e  l++i e +n  +q e  k +++ ++  l+++n+e+ +Lk+++ee++ 
  EFC35519.1 149 NEQIEQENKQVEQNLRTKEQEKIKIENKLIEIGKE----KMKIEVKLNEILEKQNSHQQPETQKRELERMKIELETANHELMDLKEKIEEEQR 237
                 588999999*******9999999******888877....88999999******************************************9876 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   4.2      0.18   1.7e+02     159     191 ..       7      37 ..       1      39 [. 0.54
   2 ?   13.9   1.6   2.4e-05     0.022      66     190 ..      34     150 ..      31     159 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.18
  ABC2_membrane_3 159 vasflvgliliilifitasfiavsiveEkesri 191
                       +s ++++++++++++ ++ ia   + E++++ 
       EFC35519.1   7 LQSVILFVLMMMMMMLLLITIA--SCDERTTKQ 37 
                      4455555555554444444444..588888875 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 2.4e-05
  ABC2_membrane_3  66 seeeakkalkngdidgilvipkgfskdllkgesatvtvlinssnlnss.......kailnalnsllqqlnasalvlqseatstsaninvestql 152
                      +++++ +a+kn+  + i+++ kg + +     + +v +++++ +  ++       k + n++++l +           e++   ++++ e  q 
       EFC35519.1  34 TTKQLHDAIKNNHWELINQLIKGGEANP----YEKVDYWFSKYDAFDIavyygntKFLTNYMKQLEK-----------EQEYKLQQLKKEQDQI 112
                      689*****************99999865....58999999777765552444444444555555432...........3334445555555555 PP

  ABC2_membrane_3 153 eeelsnvasflvgliliilifitasfiavsiveEkesr 190
                      + e++ +++f  ++++ +l+++++sf+ +++++ k + 
       EFC35519.1 113 QLETQLANQFKNTIYMTVLVIVGGSFLGYWYIQRKLNE 150
                      66666666666778888888899999999998888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (284 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3892  (0.217078); expected 358.6 (0.02)
Passed bias filter:                      685  (0.0382063); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.79u 0.36s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 1603.31
//
Query:       EFC35520.1  [L=165]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-08   34.1   1.3    4.4e-06   25.9   0.6    2.0  2  ASC       Amiloride-sensitive sodium channel


Domain annotation for each model (and alignments):
>> ASC  Amiloride-sensitive sodium channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0001       1.8     215     263 ..      22      67 ..       1      77 [. 0.75
   2 !   25.9   0.6   2.4e-10   4.4e-06     386     434 ..      90     138 ..      69     142 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0001
                 XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ASC 215 tseeseaaGfkvlihdpdevpdidkegvsvppgtetsigikpkkikrlp 263
                      +  G +v++h+p+++p++  e+  +  g  +++ +++ ++++l+
  EFC35520.1  22 R---DSRFGLQVSFHEPGTIPKVFAETNFAISGVDNYFVLTKIVTETLK 67 
                 2...3468******************99999999999999888888875 PP

  == domain 2  score: 25.9 bits;  conditional E-value: 2.4e-10
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ASC 386 eykrenlakvevyfeelnyerleeseaysltdllsdlGGllGLflGaSv 434
                 ++++enl+++++ +++ln ++++e ++ s++ ll+++ G++G+f+G+ v
  EFC35520.1  90 TQSDENLVVISIAYSSLNENKITELLTSSMEGLLGQIAGIIGIFMGLDV 138
                 46678*****************************************865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       462  (0.0257683); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1030.40
//
Query:       EFC35521.1  [L=522]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.6e-08   32.8   2.0    1.1e-07   31.5   2.0    1.6  1  Pkinase      Protein kinase domain
    4.2e-05   23.0   0.7    6.9e-05   22.3   0.7    1.2  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.5   2.0   1.2e-11   1.1e-07      53     145 ..     402     504 ..     383     513 .. 0.72

  Alignments for each domain:
  == domain 1  score: 31.5 bits;  conditional E-value: 1.2e-11
                 HHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET......TTE......EEE CS
     Pkinase  53 kklkhpnivrlyevfeekdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide......kge......lKi 139
                 k+++  ni++ ye+ e++ +  ++    +g +l ++ + k++l   ++ +i+ ++ +gl+ lH++++iH+D+Kp+N++++e      + +        i
  EFC35521.1 402 KQMHNANILT-YEITEKNGNEAIIISKYRGINLSNYRNLKTKLYLGNLLQILIKTSHGLKSLHDNNLIHCDIKPDNLFLQEtiitkkE-DnilhieTII 498
                 3333455555.5666665555555555566779999999999*************************************974555431.1333333556 PP

                 -SGTTS CS
     Pkinase 140 tDFGla 145
                 +D+G +
  EFC35521.1 499 GDLGSV 504
                 666665 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.7   7.7e-09   6.9e-05      56     144 ..     402     487 ..     390     508 .. 0.78

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 7.7e-09
                  HTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE CS
  Pkinase_Tyr  56 kklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvki 144
                  k++++ ni+ +  +  k+++  i++   +g +L+++ +   k+kl l +ll++ ++ ++G++ L++++l+H d+   N +l+e+ + k 
   EFC35521.1 402 KQMHNANILTY-EITEKNGNEAIIISKYRGINLSNYRNL--KTKLYLGNLLQILIKTSHGLKSLHDNNLIHCDIKPDNLFLQETIITKK 487
                  34566666654.45555566566666667889***9555..599**************************************9877664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       962  (0.0536561); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 3299.29
//
Query:       EFC35522.1  [L=658]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.048   13.5   1.6       0.11   12.3   1.6    1.5  1  LapA_dom   Lipopolysaccharide assembly protein A domain
        1.8    8.7   5.4        1.7    8.8   0.2    3.4  4  DUF2684    Protein of unknown function (DUF2684)


Domain annotation for each model (and alignments):
>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.6   1.2e-05      0.11      24      63 ..     563     603 ..     552     603 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.2e-05
    LapA_dom  24 lvafgiGallgwllsl.wsylrlrrelrrlkkkikklekel 63 
                 l+ f++G+ lg+ +++ w+++++ r+l++++k  k+ e++l
  EFC35522.1 563 LFLFALGIALGFGIFFvWKIVKKLRKLKSKEKAEKQIEEKL 603
                 788999998887555559999*********99999999875 PP

>> DUF2684  Protein of unknown function (DUF2684)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.31   2.8e+03      47      73 ..      50      77 ..      30      85 .. 0.67
   2 ?    8.8   0.2   0.00019       1.7       7      60 ..     202     252 ..     197     263 .. 0.85
   3 ?   -1.9   0.0      0.43   3.8e+03      40      65 ..     264     288 ..     253     311 .. 0.70
   4 ?   -0.4   0.0      0.15   1.3e+03      42      80 ..     391     429 ..     388     434 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.31
     DUF2684 47 lillktqlvi.vsdnadilriylllfsa 73
                 ++lk+ l+i +++  +ilr  +   + 
  EFC35522.1 50 SNVLKNSLKIsFTNQVNILRSSIYVTFG 77
                4788888765378889999966555554 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00019
     DUF2684   7 tslkvkdtGslsvnryGwiniwtailGqffalfplffesrlillktqlvivsdn 60 
                 ts   k  Gs+ +  y  in+w     +f+   pl   s l +  tq vi+   
  EFC35522.1 202 TSSFPKGVGSIEISSYSNINLWQC---NFYNNRPLIIGSVLSIESTQSVIFIGS 252
                 55555789**************85...8*******************9998655 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.43
     DUF2684  40 plffesrlillktqlvivsdnadilr 65 
                 pl+ e++ i  + +   + dn  +l 
  EFC35522.1 264 PLYIETCSI-FQVFNCTFRDNVALLS 288
                 888898875.5777888889887774 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.15
     DUF2684  42 ffesrlillktqlvivsdnadilriylllfsavlGikrd 80 
                 ff+  ++ll      +s+n    r+yl   s++   k+d
  EFC35522.1 391 FFNYDKNLLTLSDTTISENEIAERVYLKTVSVIGASKQD 429
                 8888899999999999***9999***8887766656655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (658 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1066  (0.0594567); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.31s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 3890.19
//
Query:       EFC35523.1  [L=347]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00052   19.9   0.2    0.00085   19.2   0.2    1.5  1  dCache_1  Cache domain
  ------ inclusion threshold ------
      0.034   14.4   0.0      0.082   13.2   0.0    1.6  1  DUF996    Protein of unknown function (DUF996)
      0.045   14.0   0.1       0.07   13.4   0.1    1.2  1  VWA       von Willebrand factor type A domain
      0.046   12.5   0.0       0.06   12.2   0.0    1.1  1  DctM      Tripartite ATP-independent periplasmic transporter,


Domain annotation for each model (and alignments):
>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.2   1.9e-07   0.00085     115     165 ..     201     251 ..      70     261 .. 0.82

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 1.9e-07
    dCache_1 115 aggggkpvisdpyvdqtgg.kpvitiavpiyddsgkfiGvlaadldldnlqd 165
                   g++++++s++y+d   g  +++t + p y+  g f+Gv+++d++++ ++ 
  EFC35523.1 201 RLGKNDIIWSNFYSDLL-GiGNMTTASLPCYSSGGMFLGVVGVDVPATLFNT 251
                 3444699******9999.8679**********99************998875 PP

>> DUF996  Protein of unknown function (DUF996)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   1.8e-05     0.082      69      96 ..     304     332 ..     283     337 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.8e-05
      DUF996  69 lillll.lvliiayvlliisavflkksye 96 
                 ++l+++ +vl++++v++i+s +f+k+s+ 
  EFC35523.1 304 VMLGFIpAVLVAFVVFVIVSFYFYKRSLM 332
                 555666155588889***********985 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   1.6e-05      0.07      20     143 ..      10     155 ..       3     164 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.6e-05
                 HHHHHHHHHHHHTBTTTTEEEEEEEESSS.......EEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHGTSST...TSEEEEE CS
         VWA  20 vkefikklveklevgpegtrvglvqfsse.......vktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssagaRe...nakkvii 108
                 + +++++l+++l+   e+++++ v f ++        kt f + ++ +k++ll+++ +l +++++ttn g+   +a e+ f   + + +   n    ++
  EFC35523.1  10 TVSALNSLLNSLN---ERDKIAAVLFTKKaiiypgnEKTGFLFATDATKSSLLDWILSLFVQTSSTTNSGSYHTAAFETSFAFLKQYSSsliNCDTSLV 105
                 5678899999999...***********66666555599999999999***********************99999999777766664344569999999 PP

                 EEESS--.CSS.....HTHHHHHHHH.........GCTEEEEEEEESSSH CS
         VWA 109 lltdGks.ndg.....dpkeaaneak.........eqgikvfavGvgnad 143
                 ++ d ++ +d+     +++++ +++          + ++  f+vG+++  
  EFC35523.1 106 VFGDADNiKDEsnpvnSLLTQYQSLSnylgtsfvkKVRVFSFSVGIQKGQ 155
                 99997773342343334444444444888888875557777777776655 PP

>> DctM  Tripartite ATP-independent periplasmic transporter, DctM component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   1.3e-05      0.06     163     208 ..     295     341 ..     290     347 .] 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.3e-05
        DctM 163 lgvsigdl.faaaiipglllavglllavaiaakkenlrsktkaelkr 208
                  +++ g+l ++ ++ip++l+a++++++v ++ +k+ l + + + +k+
  EFC35523.1 295 CNQPCGNLaVMLGFIPAVLVAFVVFVIVSFYFYKRSLMKAEGDDEKE 341
                 567777774689*********************99998866555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       685  (0.0382063); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2230.22
//
Query:       EFC35524.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1179  (0.0657594); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1381.26
//
Query:       EFC35525.1  [L=520]
Description: coatomer protein complex subunit beta [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   4.9e-117  391.7   3.0   6.3e-117  391.3   3.0    1.1  1  Coatomer_WDAD  Coatomer WD associated region
  ------ inclusion threshold ------
      0.038   14.4   1.3        3.4    8.1   0.0    3.1  3  Bacteroid_pep  Ribosomally synthesized peptide in Bacteroidet
       0.11   12.9   1.5       0.45   11.0   0.3    2.4  2  ACP_PD         Acyl carrier protein phosphodiesterase
       0.12   12.5   2.9        2.3    8.6   0.0    3.8  4  TPR_2          Tetratricopeptide repeat
       0.23   11.7   3.0        2.2    8.6   0.1    2.8  3  ANAPC3         Anaphase-promoting complex, cyclosome, subunit
       0.29   11.0   3.5        1.8    8.5   0.1    3.3  3  TPR_1          Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Coatomer_WDAD  Coatomer WD associated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  391.3   3.0  2.1e-120  6.3e-117      63     444 ..       1     385 [.       1     386 [. 0.96

  Alignments for each domain:
  == domain 1  score: 391.3 bits;  conditional E-value: 2.1e-120
                    XXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Coatomer_WDAD  63 lrnkaygkgldfvwvs.snrfavlessksvkifknfkekktksikleyqvdkifgGalLgvksegsvsfYDweqgklvrridvkkvknVvwsddge 157
                    +r+k+yg+g + vw+s s+ +av+ +s+++ki+k+fke k   +k+ ++ ++ifgG+lLg++s+++++fYDwe+ +++r+i + + ++V+w+dd  
     EFC35525.1   1 MRSKTYGSGEELVWSStSGCYAVRSKSNEIKIYKDFKEFK--VFKPFFTPKQIFGGQLLGISSKEFICFYDWETCQMIRNIGIIP-RKVYWNDD-- 91 
                    599*************9999********************..*******************************************.******99.. PP

                    XXXXXXXXXXXXXXXXXX....................XXXXXXX.XXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX.XXXXXXXXXXX. CS
  Coatomer_WDAD 158 lvalvskdtvyilsynleavee.......edeeegvedafevlhelsesiksgaWvgdvfiYttsnnrlkylvngevgiikhl.dktlyilgykgk 245
                     v ++s++++y+l+yn++ v++       e+e++ +ed++ + ++++e+i++g ++g++fiYt++++rl+y+++g+v +i hl d++ + lgy+ k
     EFC35525.1  92 SVLIASENEFYLLRYNSQLVKNalktrnpEEEDSQIEDSLILEYNIEEKIREGQFIGETFIYTNNDSRLNYVIGGQVTTITHLeDSKHFFLGYVSK 187
                    78999*************9999*****99999999************************************************457899******* PP

                    .XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......XXXXXXXXXXXXXXXX-GGGSS-HHHHHHHHHHTT-HHHHHH CS
  Coatomer_WDAD 246 enklylldkdgnvvsleidlselefktavlrkdleevlkiiaasnllpeipkeegqkiirfLekkgypelAlqlvqDpetkFdLAlelgnLelAle 341
                     n++y++dk+ n+ s+++ +++l+++t++lr+dle+      as llp+ipk+e +++++fL ++gy++lA+q++qD+e+ F++A++l++L+ A+e
     EFC35525.1 188 HNRIYIMDKERNILSFRLFVQVLQYETLILRGDLET------ASLLLPQIPKDEYNRLAKFLDQQGYKQLAMQVTQDDEHCFEIAIQLNDLQKAYE 277
                    ***********************************9......599*************************************************** PP

                    HHHHH--HH..HHHHHHHHHHHTT-HHHHHHHHHHTT-HHHHHHHHHHHT-HHHHHHHHHHHHHTT-...HHHHHHHHHHHT-HHHHHHHHHHTT- CS
  Coatomer_WDAD 342 lakelddee..kWkkLgdaAlsqgniklaeeayqkakdfdkLllLylstgnkekLkkLakiaekkgd...yniafqaalllgdvekcvdlLiksgr 432
                    ++k++++    kWk+Lg++Alsq+ni+la e+++  +df +LllLy+s g++e++ kLa++a+++      ni+f+++ llg+v++c++lLi+++r
     EFC35525.1 278 IIKKSKSALetKWKQLGQLALSQCNIELARECFELGNDFGGLLLLYSSIGDREGMIKLAEMAKNNSTtsyNNITFMCYYLLGQVDNCINLLIETKR 373
                    *****965444******************************************9999999998876522269************************ PP

                    HHHHHHHHHHTT CS
  Coatomer_WDAD 433 lpeAalfAktyg 444
                    lpeAalfA+ty 
     EFC35525.1 374 LPEAALFARTYA 385
                    **********97 PP

>> Bacteroid_pep  Ribosomally synthesized peptide in Bacteroidetes
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.7   5.1e+03      22      35 ..     160     173 ..     156     178 .. 0.76
   2 ?    8.1   0.0    0.0011       3.4      10      40 ..     399     432 ..     397     435 .. 0.82
   3 ?    3.4   0.2     0.034     1e+02      11      28 ..     449     466 ..     442     476 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.7
  Bacteroid_pep  22 lqsikGGlqtgyke 35 
                    l +++GG+ t+++ 
     EFC35525.1 160 LNYVIGGQVTTITH 173
                    789****9887765 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0011
  Bacteroid_pep  10 f.llenkkLnseqlqsikGGlqtgykeis..snf 40 
                    +  ++n+k+ns  l+si+ +l +++++     nf
     EFC35525.1 399 ElTSDNQKVNSQRLKSIADSLADPIDYPNmfNNF 432
                    55689***************99999998865555 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.034
  Bacteroid_pep  11 llenkkLnseqlqsikGG 28 
                    +l n++L+s+q q ik +
     EFC35525.1 449 KLQNNELSSNQYQNIKKS 466
                    788**********99966 PP

>> ACP_PD  Acyl carrier protein phosphodiesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.59   1.8e+03      76      98 ..     270     292 ..     245     301 .. 0.83
   2 ?   11.0   0.3   0.00015      0.45      16      68 ..     437     489 ..     427     506 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.59
      ACP_PD  76 sklaeaieeleenyaeleadFle 98 
                 ++l++a+e +++ +++le+++++
  EFC35525.1 270 NDLQKAYEIIKKSKSALETKWKQ 292
                 45888999999999999888776 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00015
      ACP_PD  16 pLeefvq.rvyaqlekneealPerlqrllprmieedwLesYaelegieralqrm 68 
                 + e+f++ ++y++l++ +e  ++++q++ +++ ++dw+e+Y++    +  ++ +
  EFC35525.1 437 QVEKFMNrDFYTKLQN-NELSSNQYQNIKKSLYNTDWIEQYKQEGESQFKINYI 489
                 5677765169999965.89999*******************9876666555555 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.74   2.2e+03       3      21 ..     235     253 ..     234     257 .. 0.84
   2 ?   -0.3   0.0      0.53   1.6e+03      10      22 ..     265     277 ..     261     283 .. 0.69
   3 ?    8.6   0.0   0.00076       2.3       4      25 ..     290     311 ..     288     312 .. 0.95
   4 ?    0.1   0.0      0.39   1.2e+03       9      22 ..     353     366 ..     353     370 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.74
       TPR_2   3 alynlGlayyklgdyeeAl 21 
                  +++l++ + ++g  + A 
  EFC35525.1 235 EYNRLAKFLDQQGYKQLAM 253
                 5999*********998886 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.53
       TPR_2  10 ayyklgdyeeAle 22 
                 ++++l+d+++A e
  EFC35525.1 265 IAIQLNDLQKAYE 277
                 4567778888766 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00076
       TPR_2   4 lynlGlayyklgdyeeAleafe 25 
                 + +lG++++ + + e A+e+fe
  EFC35525.1 290 WKQLGQLALSQCNIELARECFE 311
                 889******************8 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.39
       TPR_2   9 layyklgdyeeAle 22 
                 ++yy lg+ + +++
  EFC35525.1 353 MCYYLLGQVDNCIN 366
                 589****9998886 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.58   1.7e+03      64      64 ..     264     264 ..     211     281 .. 0.55
   2 ?    2.3   0.4     0.066     2e+02      35      63 ..     268     297 ..     251     314 .. 0.67
   3 ?    8.6   0.1   0.00073       2.2      10      65 ..     334     383 ..     330     386 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.58
                 H CS
      ANAPC3  64 q 64 
                 +
  EFC35525.1 264 E 264
                 2 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.066
                 HTT-HHHHHHHHHCTSHHHC-H.HHHHHHH CS
      ANAPC3  35 lngqykrAyellrkaklnsksl.gcrylfA 63 
                 ++++ ++Aye+++k+k++ +++ + +  +A
  EFC35525.1 268 QLNDLQKAYEIIKKSKSALETKwKQLGQLA 297
                 67889999***9999655555543333333 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00073
                 HHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHHHH CS
      ANAPC3  10 flaerllaaetespedayllAlclylngqykrAyellrkaklnskslgcrylfAqc 65 
                  lae + + +t s++++ +   c+yl+gq + +++ll ++    k l  + lfA++
  EFC35525.1 334 KLAEMAKNNSTTSYNNITF--MCYYLLGQVDNCINLLIET----KRLPEAALFART 383
                 5666666677888888777..7***************999....666556666665 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.48   1.4e+03      23      31 ..     262     270 ..     260     281 .. 0.66
   2 ?    8.5   0.1   0.00061       1.8       4      25 ..     290     311 ..     289     312 .. 0.97
   3 ?    0.9   0.0      0.15   4.4e+02       9      21 ..     353     365 ..     353     368 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.48
                 HHHHHHHHS CS
       TPR_1  23 yyekALeln 31 
                 ++e A++ln
  EFC35525.1 262 CFEIAIQLN 270
                 666666665 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00061
                 HHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   4 lynlGnayfklgkydeAleyye 25 
                 +++lG++ +++ + + A e++e
  EFC35525.1 290 WKQLGQLALSQCNIELARECFE 311
                 99*******************7 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.15
                 HHHHHTT-HHHHH CS
       TPR_1   9 nayfklgkydeAl 21 
                 ++y+ lg+ d ++
  EFC35525.1 353 MCYYLLGQVDNCI 365
                 59******99887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (520 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1316  (0.0734006); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 3227.60
//
Query:       EFC35526.1  [L=352]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        4.9    8.1   6.7       0.64   11.0   0.3    2.4  2  Gastrin   Gastrin/cholecystokinin family


Domain annotation for each model (and alignments):
>> Gastrin  Gastrin/cholecystokinin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.3   3.6e-05      0.64      44     106 ..      72     128 ..      17     131 .. 0.67
   2 ?   -0.8   1.6      0.15   2.8e+03      65     107 ..     293     332 ..     235     335 .. 0.50

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 3.6e-05
     Gastrin  44 raaasskqlkalqradeee....dqranlseLLarllsqkkkgsvrrlsaaksrlqsldanhrikDR 106
                 + ++  +q++        +    +++++++ +L++++ +kk++++++l +      s+d++ r +DR
  EFC35526.1  72 KPEPVYRQTRDK------SlkwrEEQRQINPVLQQFIDTKKEEEFKKLEQEM----SIDTMNRAMDR 128
                 334444444332......123338899*******************996555....58999999999 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.15
     Gastrin  65 ranlseLLarllsqkkkgsvrrlsaaksrlqsldanhrikDRd 107
                 ++   e  +++l++ ++ +v+r ++ak    + d ++  kDRd
  EFC35526.1 293 KEIKDENRTQYLQHIHDVQVERRPIAKV---KYDYEKELKDRD 332
                 2222333456677777777777777775...446677778887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (352 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1309  (0.0730102); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2375.19
//
Query:       EFC35527.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0021   18.6  20.1     0.0021   18.6  20.1    4.0  3  Nop25            Nucleolar protein 12 (25kDa)


Domain annotation for each model (and alignments):
>> Nop25  Nucleolar protein 12 (25kDa)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6  20.1   1.2e-07    0.0021       4     125 ..      25     152 ..      22     159 .. 0.73
   2 ?  -12.4  27.3         1   1.8e+04      71     112 ..     160     231 ..     151     257 .. 0.47
   3 ?  -13.6  29.0         1   1.8e+04      42     119 ..     244     320 ..     241     328 .] 0.52

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 1.2e-07
       Nop25   4 akkkkveevtFDkdsRkeYLTGFhKRKlqRqk...kAqeeakeqereerieeRkklreerkkeleeqleevketlkeseeeeeeeeeeeeeeeeeeeee 99 
                 +++k+v +v+FD+ds+++Y+T  +KRK   +    + q+++ e+ +++ +ee+k   +e  + l+   +++k + k++e e+  +++++ ++  ++e++
  EFC35527.1  25 TETKRVLTVKFDRDSKNQYVTNLKKRKDINRVigyEQQKRHDEKIKQQEKEEKKLRYDEMLRSLDIDPDQFKGNSKKNEYERLLKKQKTLNDGVNDEDD 123
                 6678999********************876651225566777777888888888888888888888999999999997777777777777777788999 PP

       Nop25 100 eeeewegfedee...eeeeeddeeeyide 125
                 e+++ +gf++++   +++ +++e e+ d+
  EFC35527.1 124 EDDDDDGFKSSTfnlKTDMDSSESESDDN 152
                 99999****98887633333333322222 PP

  == domain 2  score: -12.4 bits;  conditional E-value: 1
       Nop25  71 vketlkeseeeeeeeeeeeeeeeeeeeeeeeeewegfedee...............................e 112
                 +  +++++ ++++e+e ++++e++eeeee++++++  ++++                               +
  EFC35527.1 160 FLLNMNNQ-SDDDEDEADNNDESSEEEEEDNNNIKTYNNNNnedgeesssvsvtikpfnfntgsfdseessdS 231
                 44444443.2233333333344445555555555555554444444555566666666666666655444331 PP

  == domain 3  score: -13.6 bits;  conditional E-value: 1
       Nop25  42 keqereerieeRkklreerkkeleeqleevketlkeseeeeeeeeeeeeeeeeeeeeeeeeewegfedeeeeeeedde 119
                 +e++ e+++ +R+++   + +el++++ e++++ k+++++++ + ++   ++ +++++ ++e + f +++ ee+++++
  EFC35527.1 244 EEKKEERKVSIRHQVLSLKPHELNRKIVEMQREKKKEKKQKKFNPQK-AAQDLKKKKKFKKEGKSFAEKKREEKKKKQ 320
                 45666667777888777777888777777777777644333333322.223334455555555666655422222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4022  (0.224329); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                       201  (0.0112109); expected 17.9 (0.001)
Passed Fwd filter:                        68  (0.00379274); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.64u 0.42s 00:00:02.06 Elapsed: 00:00:00.63
# Mc/sec: 1575.04
//
Query:       EFC35528.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.4e-11   44.2   0.0      5e-11   43.1   0.0    1.6  1  Methyltransf_11  Methyltransferase domain
    5.5e-10   39.2   0.0    1.1e-09   38.3   0.0    1.4  1  Methyltransf_31  Methyltransferase domain
      8e-10   39.3   0.0    3.1e-09   37.4   0.0    1.9  1  Methyltransf_25  Methyltransferase domain
    0.00015   22.5   3.9     0.0011   19.7   0.0    2.8  3  Methyltransf_12  Methyltransferase domain
    0.00044   19.6   0.1      0.001   18.5   0.1    1.5  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
  ------ inclusion threshold ------
      0.023   14.7   0.0      0.041   13.9   0.0    1.6  1  Methyltransf_32  Methyltransferase domain


Domain annotation for each model (and alignments):
>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.1   0.0   1.7e-14     5e-11       3      95 ..     102     207 ..     100     208 .. 0.89

  Alignments for each domain:
  == domain 1  score: 43.1 bits;  conditional E-value: 1.7e-14
                      ET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-EEEETTEECCCT.SS-TT-EEEEEEES-CCC-..C.............CHHH CS
  Methyltransf_11   3 vGcGtGrlaealakrg.arvvgvDlskemlklakekaseeglkvefvvadaekl.pfednsfDlvvssevlhhv..e.............dpek 79 
                      +GcG+  l +++   g ++++++D+s ++++  k k+++    +e++++d+ ++  fe+++fD+v+ + +++ +  +             +  k
       EFC35528.1 102 IGCGNSTLGQDMYMDGyTNIINMDYSSKVIEKMKLKYPN----MEWIEMDMLDMkGFENETFDIVLDKGTMDALvvDagdpwdpeqhvryETLK 191
                      8***9999999996666*************999888887....569********88*****************97736778888999999**** PP

                      HHHHHHHHEEEEEEEE CS
  Methyltransf_11  80 alkeiaRvLkpgGllv 95 
                       +kei+R+Lkp G+++
       EFC35528.1 192 MCKEIYRILKPSGRFL 207
                      *************985 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3   0.0   3.5e-13   1.1e-09       2     114 ..      94     215 ..      93     250 .. 0.78

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 3.5e-13
  Methyltransf_31   2 dkglrvlDlGCGtGeltfelaeelgpkaevvGiDiseeaielArenaqklgldnveFeqgdieeleklledekfDlilsnevl........... 84 
                      +k+l++l +GCG+++l+  ++       ++++ D+s ++ie+++      ++ n+e  + d+ +++  +e e+fD++l+++++           
       EFC35528.1  94 KKELKILIIGCGNSTLGQDMYM--DGYTNIINMDYSSKVIEKMKL-----KYPNMEWIEMDMLDMKG-FENETFDIVLDKGTMdalvvdagdpw 179
                      78899999*************3..33467*************986.....799***********775.999*********99997787777777 PP

  Methyltransf_31  85 ....naladpdkileeiervlkpggilliedpr..l 114
                          +  ++  k  +ei r lkp g++l  +++  +
       EFC35528.1 180 dpeqHVRYETLKMCKEIYRILKPSGRFLQITFSqpH 215
                      777655666667777*************99988332 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.4   0.0     1e-12   3.1e-09       1      97 []      99     204 ..      99     204 .. 0.89

  Alignments for each domain:
  == domain 1  score: 37.4 bits;  conditional E-value: 1e-12
                      EEEET-TTSHHHHHHHCTSTSSEEEEEESSHHHHHHHHHHHHHTTTTEEEEESBCCGBS.SSTTTEEEEEEESTGG..............GSSH CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrlgkakvtgvDiseemleaareraeeeglnvefvqgdaedlp.fedgsfDlvvssgalh..............hlsd 79 
                      +L +GcG+ +l +++    g  +++ +D+s++ +e+++ ++    +n+e++++d+ d++ fe+++fD+v+  g++               h+  
       EFC35528.1  99 ILIIGCGNSTLGQDMYMD-GYTNIINMDYSSKVIEKMKLKY----PNMEWIEMDMLDMKgFENETFDIVLDKGTMDalvvdagdpwdpeqHVRY 187
                      788*************99.69********************....9************889**********77787777888887777766664 PP

                      HHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  80 edlekalkeiarvLkpgG 97 
                       ++ k++kei+r+Lkp G
       EFC35528.1 188 -ETLKMCKEIYRILKPSG 204
                      .4577***********98 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.5     0.055   1.6e+02      37      68 ..       5      36 ..       1      47 [. 0.55
   2 ?   -2.9   0.5       3.9   1.2e+04      47      56 ..      78      87 ..      68      96 .. 0.47
   3 !   19.7   0.0   3.6e-07    0.0011       1      99 []     100     206 ..     100     206 .. 0.79

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.055
  Methyltransf_12 37 keklakrennnnnnvelealdlldldggssfD 68
                     +++ +  +nnnnnn+  e +d  + + ++++D
       EFC35528.1  5 QQQVSNTNNNNNNNIITEPEDTNEYKFKHYWD 36
                     34444445555555555555544444446666 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.9
  Methyltransf_12 47 nnnnveleal 56
                      nnn + +++
       EFC35528.1 78 INNNTTDDNN 87
                     2222223333 PP

  == domain 3  score: 19.7 bits;  conditional E-value: 3.6e-07
  Methyltransf_12   1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvelealdlldldggssfDlvvasnvlhhl............... 79 
                      L iGcG+++l + +  +   ++++ +D+s+++ie+      k +  n +++e + ld  + +++++fD+v+  +++ +l               
       EFC35528.1 100 LIIGCGNSTLGQDMYMD-GYTNIINMDYSSKVIEKM-----KLKYPNMEWIEMDMLD-MKGFENETFDIVLDKGTMDALvvdagdpwdpeqhvr 186
                      569************99.999999*********333.....3333345567777666.4566669*********************99996554 PP

  Methyltransf_12  80 kdirevldnirklLkpgGrl 99 
                       ++ ++ ++i++ Lkp Gr+
       EFC35528.1 187 YETLKMCKEIYRILKPSGRF 206
                      44446666999*****9986 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.1   3.4e-07     0.001      42     160 ..      90     217 ..      77     225 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 3.4e-07
                      H--S--TTEEEEES-TT-HHHHHHHHHHHHHHEEEEEES-HHHHHHHHHHHHHHTSSTEEEEE--TTT.....-TTS-T-EEEEEEES-..... CS
  Ubie_methyltran  42 lvavkrgakvlDvagGtgDlafklsdsvgekgkvvvlDinenmLkvgekklkeegkinieflqanaee.....LpfeddsfDvvtvsfG..... 125
                      ++ +k+  k+l + +G + l  ++   ++   +++ +D+++++++  + k  +   i++++l  ++ e     +  +++++D + v  G     
       EFC35528.1  90 INEKKKELKILIIGCGNSTLGQDM--YMDGYTNIINMDYSSKVIEKMKLKYPNMEWIEMDMLDMKGFEnetfdIVLDKGTMDALVVDAGdpwdp 181
                      555666778888877777666555..56677789999999999999999999999998888877665411111445779999999999833322 PP

                      .GGG-S-HHHHHHHHHHHEEEEEEEEEEEE----SH CS
  Ubie_methyltran 126 .lrnvtDklkaLkeayrvlkpGGrlvvlefskvelp 160
                            ++lk  ke+yr+lkp Gr++ + fs+++  
       EFC35528.1 182 eQHVRYETLKMCKEIYRILKPSGRFLQITFSQPHFR 217
                      211223567899********************9865 PP

>> Methyltransf_32  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   1.4e-05     0.041      19      70 ..      89     137 ..      57     177 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.4e-05
  Methyltransf_32  19 elakesgaltvvDvGaGkgYLsfvlalkekeyklkvvgidakeelvekaekr 70 
                      ++++++++l+++ +G+G++ L++ ++    +  ++++ +d +++++ek +  
       EFC35528.1  89 TINEKKKELKILIIGCGNSTLGQDMYM---DGYTNIINMDYSSKVIEKMKLK 137
                      34678999*******************...8789************998755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1348  (0.0751855); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1502.77
//
Query:       EFC35529.1  [L=546]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.8e-50  170.4   0.2    7.8e-50  169.7   0.2    1.2  1  Pkinase         Protein kinase domain
    3.6e-46  157.5   0.2    1.1e-41  142.9   0.1    2.2  2  Pkinase_Tyr     Protein tyrosine kinase
    1.7e-06   28.3  52.4     0.0087   16.4   7.8    3.9  4  EGF_2           EGF-like domain
      0.001   18.0   0.1     0.0015   17.4   0.1    1.2  1  Pkinase_fungal  Fungal protein kinase
     0.0016   17.5   0.7      0.004   16.2   0.0    2.0  2  Haspin_kinase   Haspin like kinase domain
     0.0042   17.0   0.0     0.0065   16.4   0.0    1.2  1  APH             Phosphotransferase enzyme family
      0.005   16.2   0.0     0.0083   15.5   0.0    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
       0.01   14.9   0.1      0.021   13.9   0.1    1.5  1  Seadorna_VP7    Seadornavirus VP7
      0.015   14.6   0.0      0.027   13.8   0.0    1.4  1  Kinase-like     Kinase-like
      0.047   14.0  27.2        1.2    9.5   6.3    4.0  3  EGF             EGF-like domain
       0.15   11.7   0.0       0.24   11.0   0.0    1.4  1  RIO1            RIO1 family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.7   0.2   4.8e-53   7.8e-50       4     260 ..     244     536 ..     242     538 .. 0.82

  Alignments for each domain:
  == domain 1  score: 169.7 bits;  conditional E-value: 4.8e-53
                 EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS--HH CS
     Pkinase   4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgslsee 98 
                  e+lGeG+ G+V+  +   +g ivAvK+++ ++ + ++ +++ +E  +l kl+hpni+++y+v ++++++y+++e++++ ++++++     ++ +ls +
  EFC35529.1 244 TERLGEGGIGSVFMSK--YNGMIVAVKVFDLNNLNISE-EDFKNEAILLSKLRHPNIINFYGVSTSPTKRYIIMECLDQ-SMEKVIAklefKQLTLSLD 338
                 689**********998..8************9988766.59************************************95.5888877787888899999 PP

                 HHHHHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH....TTSCBSHHHHHHHHHHHHH CS
     Pkinase  99 eakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl....keneyskkvDvWslGvily 188
                 +  k++ +i++g+eylHs +   iiHrDlKp+NiL+d++g+ K++DFGl+k +++ +   lt++ gt+ Y++PE+      +  y ++vD++s  +i++
  EFC35529.1 339 QKLKMILNIANGIEYLHSLKprkIIHRDLKPQNILLDSNGNCKLCDFGLSKSISQATVsaLTNQLGTHFYMSPEMFdinaVDPTYATAVDIYSFSIIMW 437
                 *****************977777*******************************998789***************9887666889************** PP

                 HHHHS.S-STTTSSHHHHHHHHHHTHHHHHHHCT.........SHH...HHHTTS.............................-HHHHHHHHHHT-SS CS
     Pkinase 189 elltg.kppfsgekgkekvekeldqlekilkilg.........etkeklpeasei.............................seeakdllkkllkkd 248
                 +ll++ k p+   k++e ++k  ++  ++ ++           +     +                                    ++ +l+k++++ d
  EFC35529.1 438 QLLFEiKDPYL-FKSSELFHKLKTK--SLEQVSSyqltkmiceN-----N----YrpsipfqsinectdwctefmkselgntstIFKLGQLIKECWQAD 524
                 **986344554.2333333333322..23333322112122211.....2....1234466777899*************9865567789********* PP

                 GCCSTTHHHHHT CS
     Pkinase 249 pkkRltaeellq 260
                 pk R+++e++++
  EFC35529.1 525 PKLRPSIEQVVD 536
                 *********986 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.9   0.1   6.5e-45   1.1e-41       5     229 ..     245     487 ..     242     509 .. 0.83
   2 !   12.5   0.0   3.9e-05     0.063     233     259 .]     512     538 ..     505     538 .. 0.89

  Alignments for each domain:
  == domain 1  score: 142.9 bits;  conditional E-value: 6.5e-45
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTE..BHHHHHHHTCTTTS CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgG..dLlkfLrkkekekl 100
                  ++lGeG  G+V++ +++       + VavK+++ ++ + ++e++ +ea +++kl+hpni++++gv t+  + +i++e +++   ++   L+ k + +l
   EFC35529.1 245 ERLGEGGIGSVFMSKYN------GMIVAVKVFDLNNLNISEEDFKNEAILLSKLRHPNIINFYGVSTSPTKRYIIMECLDQSmeKVIAKLEFK-QLTL 335
                  79***************......9*********9999999*************************************9987533455555555.8899 PP

                  BHHHHHHHHHHHHHHHHHHHH...TTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE....EEHHHHHHHH CS
  Pkinase_Tyr 101 tlkdllsfalqvAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk....ftsksDvWsf 191
                  +l+++l+++l++A+G+eyL+s   +k++Hrdl  +N+Ll++n  +k++DfGL+++i ++ + ++ +++     +m+pE+++ +     + ++ D++sf
   EFC35529.1 336 SLDQKLKMILNIANGIEYLHSlkpRKIIHRDLKPQNILLDSNGNCKLCDFGLSKSI-SQATVSALTNQLGTHFYMSPEMFDINAvdptYATAVDIYSF 432
                  999****************9844467******************************.6777778888888999******998877888********** PP

                  HHHHHHHHTTSSGT................TTTSHHHHHHHHH.HTTEES-BBTT CS
  Pkinase_Tyr 192 GvllwEiftlgesp................ypglkneevlekl.kegkrlekpek 229
                  ++++w ++   ++p                ++++++ ++++++ ++++r + p +
   EFC35529.1 433 SIIMWQLLFEIKDPylfksselfhklktksLEQVSSYQLTKMIcENNYRPSIPFQ 487
                  **************66666666666666655566666666666555666555554 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 3.9e-05
                  HHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 233 elyelmkkcweedpeeRptfselvekl 259
                  +l +l+k+cw++dp+ Rp+++++v++l
   EFC35529.1 512 KLGQLIKECWQADPKLRPSIEQVVDQL 538
                  57799******************9986 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9  11.3   3.2e-05     0.051       1      32 []     119     152 ..     119     152 .. 0.84
   2 !   16.4   7.8   5.4e-06    0.0087       5      32 .]     165     192 ..     161     192 .. 0.87
   3 !   15.9  10.6   7.5e-06     0.012       1      32 []     197     231 ..     197     231 .. 0.92
   4 ?   -3.4   0.5       8.3   1.3e+04      11      15 ..     377     381 ..     376     386 .. 0.53

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 3.2e-05
       EGF_2   1 Csas..deiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 C  s  +  C+g+G+Cv++  +C+C +  y+G +C
  EFC35529.1 119 CFGSlgQFSCSGRGKCVEPD-NCSClQGLYTGSQC 152
                 666666788********999.8***777777***9 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 5.4e-06
       EGF_2   5 deiCgg.hGtC.vnqcGqCdCdsgyqGktC 32 
                 ++ C+  +GtC +  ++qC C++g++G+ C
  EFC35529.1 165 SSVCSYmNGTCgI--NNQCTCKDGFYGNMC 192
                 6789988****99..88***********99 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 7.5e-06
       EGF_2   1 Csas..deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 C +   +e Cgg  +GtC+++  +C+C+++++G  C
  EFC35529.1 197 CFSQivGESCGGslRGTCIHKD-RCSCNQHFTGERC 231
                 776678999**********999.************9 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 8.3
       EGF_2  11 hGtCv 15 
                 +G C 
  EFC35529.1 377 NGNCK 381
                 45554 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.1   9.1e-07    0.0015     304     387 ..     339     415 ..     315     439 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 9.1e-07
  Pkinase_fungal 304 spkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlk 387
                     ++++++  +++ I+ + sL    +i+HrD   +Nil+      ++ +  L D+ l k++s+  + s+  ++ GT  +m+ e+  
      EFC35529.1 339 QKLKMILNIANGIEYLHSLK-PRKIIHRDLKPQNILLD-----SNGNCKLCDFGLSKSISQ-ATVSALTNQLGTHFYMSPEMFD 415
                     5666777788999999***9.****************9.....456677***********7.6666679**********88876 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   2.5e-06     0.004     230     257 ..     364     391 ..     256     409 .. 0.91
   2 ?   -1.7   0.1      0.64     1e+03      56     121 ..     455     525 ..     440     536 .. 0.55

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 2.5e-06
  Haspin_kinase 230 HRdLhldniLvdknlnvtlidlklsRle 257
                    HRdL+ +niL+d+n+n  l+d+ ls+  
     EFC35529.1 364 HRDLKPQNILLDSNGNCKLCDFGLSKSI 391
                    ************************9865 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.64
  Haspin_kinase  56 kikkklrnsesllslnsqeev..kdfdevilsqilelc.kikkilnea..dlasllndseklssevyqtke 121
                    + k k ++ e++ s + ++ +  +++  +i  q ++ c +  +   +     +s++ +  +l +e +q+  
     EFC35529.1 455 FHKLKTKSLEQVSSYQLTKMIceNNYRPSIPFQSINECtDWCTEFMKSelGNTSTIFKLGQLIKECWQADP 525
                    44555555566655555555555788888887777777544332222211233333346677777777665 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0     4e-06    0.0065     159     195 ..     353     387 ..     314     391 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 4e-06
                 H--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT CS
         APH 159 llpgelptvllHgDlhpgNllvdpddgrvtGviDfed 195
                  l++  p+ ++H+Dl+p+N+l+d++++    + Df++
  EFC35529.1 353 YLHSLKPRKIIHRDLKPQNILLDSNGNCK--LCDFGL 387
                 34446679***************666555..677765 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   5.1e-06    0.0083      93     171 ..     311     390 ..     272     403 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 5.1e-06
         Kdo  93 lllterlegaqdLedllakwae....laeelkrallkavgrliaklhra...gvnHadlyaknillqqeeeeeaeiwliDldkarl 171
                  +++e l+  q++e+++ak +     l+   k +++ +++  i+ lh++   ++ H+dl ++nill+ ++    ++ l D+  ++ 
  EFC35529.1 311 YIIMECLD--QSMEKVIAKLEFkqltLSLDQKLKMILNIANGIEYLHSLkprKIIHRDLKPQNILLDSNG----NCKLCDFGLSKS 390
                 57788887..466666665433346677777888999**********96333699**************9....888889865554 PP

>> Seadorna_VP7  Seadornavirus VP7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   1.3e-05     0.021     147     187 ..     347     385 ..     337     399 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.3e-05
  Seadorna_VP7 147 ivaglkdLmdfhsestnllhGDcnpenlmcDknGylklvDP 187
                   i  g++ L+ +     +++h D +p+n++ D+nG+ kl D 
    EFC35529.1 347 IANGIEYLHSLK--PRKIIHRDLKPQNILLDSNGNCKLCDF 385
                   344455554444..5789********************995 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.7e-05     0.027     140     215 ..     336     416 ..     300     443 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.7e-05
  Kinase-like 140 kletiarlllTl.qlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvlseve.....kgfaPpEllgs 215
                  +l +  + +l + + i    +L+ + ++h +++++n+lld +g  +l +f+ L +   ++ +s        + +  pE++  
   EFC35529.1 336 SLDQKLKMILNIaNGIEYLHSLKPRKIIHRDLKPQNILLDSNGNCKLCDFG-LSKSISQATVSALTnqlgtHFYMSPEMFDI 416
                  33334444443313466677788899************************7.455444444444333444445566666655 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   6.3   0.00074       1.2       6      31 ..     128     150 ..     119     151 .. 0.90
   2 ?    7.4   3.5    0.0035       5.6       9      31 ..     172     190 ..     170     190 .. 0.90
   3 ?    7.7   2.0    0.0026       4.3       9      32 .]     211     230 ..     211     230 .. 0.91

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00074
                 STTT-EEEEETTTEEEEEECTT.EEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeG.ytGk 31 
                 Cs++G+Cv++     +C C +G ytG+
  EFC35529.1 128 CSGRGKCVEPD----NCSCLQGlYTGS 150
                 ***********....**********97 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0035
                 T-EE.EEETTTEEEEEECTTEEST CS
         EGF   9 gGtC.vdtgrggytCiCpeGytGk 31 
                 +GtC ++++     C+C+ G+ G+
  EFC35529.1 172 NGTCgINNQ-----CTCKDGFYGN 190
                 899*99999.....*******996 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0026
                 T-EEEEETTTEEEEEECTTEESTT CS
         EGF   9 gGtCvdtgrggytCiCpeGytGkr 32 
                 +GtC+       +C C +++tG+r
  EFC35529.1 211 RGTCIHKD----RCSCNQHFTGER 230
                 599*9999....**********97 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00015      0.24      81     150 ..     310     386 ..     266     400 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00015
                 TEEEEE--E...ETTEEGGBHHHCG.-.HHHHHHHHHHHHH..HHHHHHHTSTEEESS-STTSEEEETT.EEEE--GT CS
        RIO1  81 hvlvmefig...edgvaapklkdve.e.eeeaeelyeevle..emrklykeaglvHaDLSeyNvlvded.kvviIDvs 150
                   ++me ++   e+ +a  + k+++ + +++++    ++ +  e+   +k  +++H DL   N+l+d++ ++ + D++
  EFC35529.1 310 RYIIMECLDqsmEKVIAKLEFKQLTlSlDQKLKM-ILNIANgiEYLHSLKPRKIIHRDLKPQNILLDSNgNCKLCDFG 386
                 5678888885222333334445555333444443.3333334444556679*****************9999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (546 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       658  (0.0367003); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.48
# Mc/sec: 3438.62
//
Query:       EFC35530.1  [L=141]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-43  144.9   4.3    1.3e-16   60.1   0.2    4.1  4  DUF4116   Domain of unknown function (DUF4116)
     0.0058   17.2   0.3      0.023   15.2   0.0    2.0  2  CbiG_C    Cobalamin synthesis G C-terminus


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   5.7e-06     0.051      31      49 .]       1      19 [.       1      19 [. 0.92
   2 !   60.1   0.2   1.4e-20   1.3e-16       1      49 []      20      68 ..      20      68 .. 0.99
   3 !   52.9   0.1   2.4e-18   2.2e-14       1      49 []      70     119 ..      70     119 .. 0.96
   4 !   36.5   0.1   3.1e-13   2.8e-09       8      45 ..     103     140 ..     103     141 .] 0.94

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.7e-06
     DUF4116 31 lkAvkqngtalsyaseeLr 49
                ++Avkqng al ++++ Lr
  EFC35530.1  1 MEAVKQNGLALQHVCHYLR 19
                899*********9999998 PP

  == domain 2  score: 60.1 bits;  conditional E-value: 1.4e-20
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                D+Eivl a+k+n sa++++s e+knD+e+v++ vk++g  ++yas+ Lr
  EFC35530.1 20 DKEIVLAAIKQNMSAFEFASIEIKNDRELVMELVKKCGWMFEYASKQLR 68
                9**********************************************98 PP

  == domain 3  score: 52.9 bits;  conditional E-value: 2.4e-18
     DUF4116   1 DrEivleavkkngs.alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+ea+ ++   ++k++s+eL+nD+++++ A+k++ + l yasee+r
  EFC35530.1  70 DREIVTEAINRHADiVYKHVSKELRNDRQLAMIAIKNHACLLAYASEEIR 119
                 9***********645*********************************98 PP

  == domain 4  score: 36.5 bits;  conditional E-value: 3.1e-13
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 a+k++ + l y+see++nDkeiv++A+k     l++as
  EFC35530.1 103 AIKNHACLLAYASEEIRNDKEIVMEAIKGKRETLKMAS 140
                 89**************************9999999988 PP

>> CbiG_C  Cobalamin synthesis G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   2.6e-06     0.023      20      66 ..      14      66 ..       2      90 .. 0.78
   2 ?    0.6   0.1     0.092   8.2e+02      34      46 ..     110     122 ..      69     140 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.6e-06
                HHHHHHHCT--GGGEEE......EEESSCCSHHHHHHHHHHHCTSTEEEE-HH CS
      CbiG_C 20 ieealeeaglseeavaa......latidlKadepgllelaeklglplktfsae 66
                + + l+++++  +a+++      +a+i++K+d + ++el++k+g+ +++ s++
  EFC35530.1 14 VCHYLRDKEIVLAAIKQnmsafeFASIEIKNDRELVMELVKKCGWMFEYASKQ 66
                55556666666666666666666**********************99977664 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.092
                 EEEEEESSCCSHH CS
      CbiG_C  34 vaalatidlKade 46 
                 + a a+ ++++d+
  EFC35530.1 110 LLAYASEEIRNDK 122
                 1224444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       711  (0.0396564); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 878.76
//
Query:       EFC35531.1  [L=188]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (188 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       339  (0.0189079); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1227.39
//
Query:       EFC35532.1  [L=176]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0059   15.7   1.2     0.0097   15.1   1.2    1.3  1  AAA_9     ATP-binding dynein motor region


Domain annotation for each model (and alignments):
>> AAA_9  ATP-binding dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   1.2   5.4e-07    0.0097      36     120 ..       2      85 ..       1      98 [. 0.82

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 5.4e-07
                 THHHHHHH......HEESTTSTTHHHHHHHHHHTTSEEEESTT.SSHHSTTHHHHTTCCEE..CEEEESSSE.EE--S.SCEEEEE CS
       AAA_9  36 qankwiknkekeklkviklsdkkflktLenairfGkplliedvgeeldpiLepvLekeiikkgrkliklgdkeieyse.nFrLylt 120
                 + n+wik  ++++ k  k+s+k+      n i++ + +++ d++++l+p ++ v+ ++i++  ++ i+++ +++ey+e +F  + +
  EFC35532.1   2 KQNTWIKLVNTSNTKFKKISKKQASIIESNHIKYEEEVFLGDIQSKLQPKFMIVVFRSIYQ--NNNIQFTYDTVEYQEhKFVVFCI 85 
                 5689***987788777777775555555689****************************99..578**********7625776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       809  (0.0451224); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.36u 0.22s 00:00:00.57 Elapsed: 00:00:00.37
# Mc/sec: 1422.81
//
Query:       EFC35533.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.77    9.9   6.2        1.7    8.8   2.4    2.2  2  DMPK_coil  DMPK coiled coil domain like


Domain annotation for each model (and alignments):
>> DMPK_coil  DMPK coiled coil domain like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.3    0.0017        31      17      56 ..      72     113 ..      69     114 .. 0.76
   2 ?    8.8   2.4   9.5e-05       1.7      29      58 ..     111     140 ..     104     143 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0017
   DMPK_coil  17 qeeLekvkaanlafes.kLkeaEkknre.LeeeleqLkkemE 56 
                 ++e + v +  + + + kL  +E  +++ L+e++  L k+ E
  EFC35533.1  72 SDETQGVIELTIGTKClKLEKTEITSQDfLQEQVYLLEKKFE 113
                 566666666677777769*********966778888888877 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 9.5e-05
   DMPK_coil  29 afeskLkeaEkknreLeeeleqLkkemEel 58 
                 +fe+ Lke   k + L++e+++L+   Eel
  EFC35533.1 111 KFERMLKENDNKIKSLNDEVNSLRAMNEEL 140
                 79**********************998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1591  (0.0887389); expected 358.6 (0.02)
Passed bias filter:                      752  (0.0419432); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 1092.25
//
Query:       EFC35534.1  [L=217]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       381  (0.0212505); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.30s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1450.62
//
Query:       EFC35535.1  [L=235]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-16   59.0   0.0    7.9e-16   58.2   0.0    1.4  1  P5CR_dimer      Pyrroline-5-carboxylate reductase dimerisatio
    8.7e-11   42.3   0.4    1.4e-10   41.6   0.4    1.4  1  F420_oxidored   NADP oxidoreductase coenzyme F420-dependent
    0.00017   21.8   0.1    0.00056   20.1   0.0    1.9  2  NAD_binding_2   NAD binding domain of 6-phosphogluconate dehy
     0.0038   16.3   0.0      0.011   14.7   0.1    1.7  2  PDH             Prephenate dehydrogenase
  ------ inclusion threshold ------
      0.038   14.0   1.0      0.061   13.3   1.0    1.3  1  NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogen


Domain annotation for each model (and alignments):
>> P5CR_dimer  Pyrroline-5-carboxylate reductase dimerisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.2   0.0   2.2e-19   7.9e-16       1      51 [.     179     229 ..     179     233 .. 0.96

  Alignments for each domain:
  == domain 1  score: 58.2 bits;  conditional E-value: 2.2e-19
                 CCHHHHHHHHTTTHHHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHH CS
  P5CR_dimer   1 EkqldavtalsGsgpAyvflliealadagvklGlsreeArelaaqtvaGaa 51 
                 E++ld vt+lsGsgpA+vf++iealad+gv  Glsre+++ la+qtv+G+ 
  EFC35535.1 179 ENYLDCVTGLSGSGPAFVFMFIEALADGGVFTGLSRETSLILATQTVLGLQ 229
                 789**********************************************86 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.6   0.4     4e-14   1.4e-10       4      97 .]       1      99 [.       1      99 [. 0.90

  Alignments for each domain:
  == domain 1  score: 41.6 bits;  conditional E-value: 4e-14
                   EETTSHHHHHHHHHHHHTTS.-GGCEEEEEESSCCCHHHHHHHHC-EEECECHHHHHHH-SEEEE-S-HHHHHHHHHHC......GHHHHTTSEEEEE CS
  F420_oxidored  4 iiGaGnmgealasgllaaga.qpheivvansrnpekaeelaeelgvkvtavdneeaaeeadvvvlavkpedveevlsel......akdalkgklvisv 94
                   +iG+G m  a++ gl+++   + ++i+ + + + + ++e  ++ +++ ++ + +e+++++ v++l vkp+++ +v++++        +++++ l+is+
     EFC35535.1  1 FIGTGAMNGAIIYGLIKSKIiKSEQIY-GYDASDKILNECVKKNEIQKCQ-SSNELIQKCQVIILGVKPQYLNQVINQInnsliqVIKEKREILLISI 96
                   8*******************9******.*9********************.99999***********************7776654555666677888 PP

                   SSS CS
  F420_oxidored 95 lag 97
                   +ag
     EFC35535.1 97 AAG 99
                   775 PP

>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.0   1.6e-07   0.00056       4      83 ..       1      88 [.       1     118 [. 0.77
   2 ?   -1.6   0.0      0.77   2.7e+03     142     154 ..     163     175 ..     156     177 .. 0.81

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 1.6e-07
                   EE--SHHHHHHHHHH....HHTT-EEEEE-SSHHHHHHHHHTT.EEE-SSHHHHHHHCSEEEE-SSSHHHHHHHHHS....HCCC--TT CS
  NAD_binding_2  4 fiGlGvMGsnmalnl....lkagykvavynrtkekveelvaeg.akaaesieelvasldvvitmvkagkavdevieg....llealkkg 83
                   fiG+G M   ++  l    + +  ++++y+ + + ++e v+++ ++ ++s +el+++++v+i+ vk  +  ++vi++    l++ +k+ 
     EFC35535.1  1 FIGTGAMNGAIIYGLikskIIKSEQIYGYDASDKILNECVKKNeIQKCQSSNELIQKCQVIILGVKP-QYLNQVINQinnsLIQVIKEK 88
                   89*****888877772322346789***************9977*********************85.778888888444555555544 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.77
                    HHHHHHHHEEEEE CS
  NAD_binding_2 142 vkpvleaigakvt 154
                    v+ ++++ig++v+
     EFC35535.1 163 VEIIFSKIGKCVF 175
                    6779*******98 PP

>> PDH  Prephenate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.1   3.1e-06     0.011      11      68 ..      23      80 ..      15     116 .. 0.88
   2 ?   -1.6   0.0      0.31   1.1e+03     126     178 ..     147     199 ..     144     206 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 3.1e-06
                -SEEEEE-SSHHHHHHHHHTTSSSEEES-GGGGCCGSEEEE-S-GGGHHHHHHHHHHH CS
         PDH 11 kvtvigydideekaeaalelglvdeatddieavkeadivvlavPvevilevlkelaph 68
                + +++gyd++++  ++ ++ + + +++ + e ++++++++l v ++ +++v++++ + 
  EFC35535.1 23 SEQIYGYDASDKILNECVKKNEIQKCQSSNELIQKCQVIILGVKPQYLNQVINQINNS 80
                468************************99*****************999999987764 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.31
                 EEEEE-TTS-HHHHHHHHHHHHHCT-EEEE--HHHHHHHHHHHTHHHHHHHHH CS
         PDH 126 viLtPtektdkealekvkelleevgarvilmspeeHDrvvavvshlphvvaia 178
                 +i+ P +++d +  ++v  ++ ++g  v l++ +  D v+++    p +v++ 
  EFC35535.1 147 YIMHPLNNNDFKFKQIVEIIFSKIGKCVFLTDENYLDCVTGLSGSGPAFVFMF 199
                 78888887775555556667788888888888888888888888888877765 PP

>> NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   1.0   1.7e-05     0.061      42     122 ..      30     113 ..      16     129 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.7e-05
                     SSBTTTBTT----TTEEEES-HHHHHTT--EEEE---HHHHHHHHHHHCCC-......-TT-EEEE---SEET.TTEEHHHHHHHHH CS
  NAD_Gly3P_dh_N  42 henvkyLpgiklpenlvattdlaealkgadiivlvvPsqalrevlkklkgll......kkkailvsliKGieegtlkllsevieeel 122
                         k L++    ++++  +  +e ++++++i+l v  q+l++v++++++ l      k++  l+s++ G++     ++ e ++++l
      EFC35535.1  30 DASDKILNECVKKNEIQKCQSSNELIQKCQVIILGVKPQYLNQVINQINNSLiqvikeKREILLISIAAGFKL---TTIYEQLNQNL 113
                     566788889999999**********************************999899987778889999999976...33333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1173  (0.0654247); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1443.04
//
Query:       EFC35536.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    6.8e-64  211.8   5.2    1.2e-21   76.4   0.0    3.0  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.0   0.6   7.9e-25   1.4e-20       2      96 ..       6      99 ..       5     100 .. 0.94
   2 !   63.8   0.1   5.8e-22     1e-17       3      94 ..     105     191 ..     103     194 .. 0.95
   3 !   76.4   0.0   6.9e-26   1.2e-21       6      93 ..     202     289 ..     198     291 .] 0.96

  Alignments for each domain:
  == domain 1  score: 73.0 bits;  conditional E-value: 7.9e-25
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCTT CS
   Mito_carr  2 elsvlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllkk 96
                +l++ +++l Ggl+g++at++++P+d++Ktr+q+ ++ + k  s ++++v  +i k+eG++ +y+Gl+++l+r++ ++  ++++++tl ++l +k
  EFC35536.1  6 QLTTGQNFLFGGLSGCLATVIIQPTDFLKTRMQLLGEGQGKGSS-NFVQVATSIAKNEGISTFYKGLSAALFRQVTYTTTRLGVFNTLMDFLSNK 99
                678899*****************************999888655.5********************************************99887 PP

  == domain 2  score: 63.8 bits;  conditional E-value: 5.8e-22
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
   Mito_carr   3 lsvlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlll 94 
                  +++ +l +G++ag ++++v tP d+  +r+ + + ++++     i+d+l+ki k+eG++ l+rG++p+++r ++ +a+++++y + k+ ll
  EFC35536.1 105 PNFATKLGCGMIAGGIGAIVGTPADLSLIRMTSGRYNYSN-----IFDALYKISKNEGILNLWRGCSPTVIRAIVLNAAQLGVYAQAKQSLL 191
                 578999***************************9999998.....*******************************************9886 PP

  == domain 3  score: 76.4 bits;  conditional E-value: 6.9e-26
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   6 lkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrll 93 
                 l ++ a+++ag v t+v  P+d++Ktrlq+ +kss++ ++++ +dv+ k++k+eGl +l++G++p ++r  p++  +f++ e++k+++
  EFC35536.1 202 LLHISASLIAGYVCTVVSIPVDLAKTRLQSMQKSSNSIQYTGSIDVITKTIKHEGLFSLWKGFWPYFFRLGPQTIFTFLFLEQFKNHF 289
                 668899*******************************************************************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       451  (0.0251548); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1805.87
//
Query:       EFC35537.1  [L=173]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.14   11.3   0.0       0.18   10.9   0.0    1.1  1  Glyco_hydro_99  Glycosyl hydrolase family 99


Domain annotation for each model (and alignments):
>> Glyco_hydro_99  Glycosyl hydrolase family 99
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0     1e-05      0.18     122     193 ..      30     101 ..      21     117 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 1e-05
                     E---TT--HHHHHHHHHHHHHHHTTSTTB--BTTB-EEEETTGGG.S-HHHHHHHHSTT-TT--TTSTT--EE CS
  Glyco_hydro_99 122 iepyssrdaqnlrenikklidkyGnhpafyrkkgkplfyiydsyl.ikpsewakllapgGelsvrnseydglf 193
                     ie y+ ++++nlr+ +++l++    hp +  ++ +p+  + +  + ++pse ++l+ +   + vrn +    +
      EFC35537.1  30 IETYQ-KENNNLRDYLQQLVNICNGHPLLNNNNNNPIKPVNNNLInTQPSENENLFITRNPVNVRNLPTSRNL 101
                     77765.6789******************************99876489*****************98766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (173 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1002  (0.0558871); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1111.35
//
Query:       EFC35538.1  [L=197]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      7e-47  159.0   7.0    2.4e-45  154.0   7.0    2.0  1  Ras            Ras family
      4e-21   75.5   3.3    1.8e-19   70.1   1.0    2.6  2  Roc            Ras of Complex, Roc, domain of DAPkinase
    2.7e-11   43.2   4.1    1.3e-09   37.7   4.1    2.1  1  Arf            ADP-ribosylation factor family
    4.5e-06   26.7   0.3    6.7e-06   26.2   0.3    1.5  1  MMR_HSR1       50S ribosome-binding GTPase
     0.0012   18.4   1.7       0.17   11.4   1.7    2.1  1  FeoB_N         Ferrous iron transport protein B
     0.0013   18.7   2.5       0.78    9.6   0.8    2.3  2  RsgA_GTPase    RsgA GTPase
     0.0039   16.7   0.1     0.0077   15.8   0.1    1.5  1  AAA_7          P-loop containing dynein motor region
     0.0045   16.4   1.0      0.022   14.2   0.1    2.0  2  SRPRB          Signal recognition particle receptor beta subu
      0.005   16.3   0.0      0.014   14.8   0.0    1.7  2  TniB           Bacterial TniB protein
  ------ inclusion threshold ------
      0.013   14.8   0.2      0.013   14.8   0.2    1.7  2  Septin         Septin
      0.017   14.5   3.5       0.18   11.1   0.2    2.1  2  Gtr1_RagA      Gtr1/RagA G protein conserved region
      0.025   14.2   0.1      0.031   13.9   0.1    1.2  1  PRP8_domainIV  PRP8 domain IV core
      0.078   13.4   0.0       0.12   12.8   0.0    1.5  1  AAA_16         AAA ATPase domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  154.0   7.0   1.7e-48   2.4e-45       1     161 [.      11     159 ..      11     160 .. 0.98

  Alignments for each domain:
  == domain 1  score: 154.0 bits;  conditional E-value: 1.7e-48
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 KlvlvGdsa+GK+s++++f++d+Fke++ +Tigvdf++k ++v+ k+vkl+i+DTAG             +a+gi+lvyd+t++e+f+n+k+w++e   
  EFC35538.1  11 KLVLVGDSATGKSSIITQFTEDEFKEQMSPTIGVDFKVKFMNVNRKKVKLTIFDTAG-------------NAHGIILVYDVTREETFNNIKNWLKECDL 96 
                 9********************************************************.............699***********************999 PP

                 HST.TTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHHHHHHHHHHHH CS
         Ras 100 vae.envpivLvGnKvDleekravsteegeelakelglkfletSAktnenveeafeellreil 161
                 + + e+++ +L+GnK+Dl+e+r+vs ++++++ak++++ ++etSAkt+env++afee++ +il
  EFC35538.1  97 YSTfEECVKLLIGNKIDLKEERKVSLQDAQNFAKSNNMVYIETSAKTKENVDKAFEEVVYQIL 159
                 998989****************************************************99986 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.1   1.0   1.3e-22   1.8e-19       1     120 []      11     114 ..      11     114 .. 0.87
   2 ?   -2.2   0.1       3.2   4.4e+03      78      97 ..     130     149 ..     121     162 .. 0.50

  Alignments for each domain:
  == domain 1  score: 70.1 bits;  conditional E-value: 1.3e-22
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K+vlvGds++GK+s++++f+ed+f+e+ ++tigvdf+ k + +++        kkvkl i+DtaG             +a+ +ilvyd   +++++n+k
  EFC35538.1  11 KLVLVGDSATGKSSIITQFTEDEFKEQMSPTIGVDFKVKFM-NVNR-------KKVKLTIFDTAG-------------NAHGIILVYDvtrEETFNNIK 88 
                 99**********************************98754.4433.......6799********.............5899*****986566789*** PP

                 HHHHHHHHHCS..SS-EEEEEE-TTT CS
         Roc  97 eWlkelkkvag..kspvilvgnkiDl 120
                 +Wlke++ +++  +++ +l+gnkiDl
  EFC35538.1  89 NWLKECDLYSTfeECVKLLIGNKIDL 114
                 ******999764266778******95 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 3.2
                 CTSCEEEEEEEGHHHHCHHH CS
         Roc  78 reaalailvydsrssenlke 97 
                 ++++++ + + ++++en+++
  EFC35538.1 130 KSNNMVYIETSAKTKENVDK 149
                 33333333333444444433 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.7   4.1   9.7e-13   1.3e-09      12     173 ..       7     156 ..       1     158 [. 0.83

  Alignments for each domain:
  == domain 1  score: 37.7 bits;  conditional E-value: 9.7e-13
                 TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSS..EEEE..EEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHH CS
         Arf  12 kkelrilllGLDnaGKtTilkklkleelvt.tvPTig..fnve..eleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLk 105
                 +++++++l+G  ++GK+ i+++++++e+++ ++PTig  f+v+  +++ k++k+t++D  G+              +++i v D++ +e +++ k+ Lk
  EFC35538.1   7 DHNFKLVLVGDSATGKSSIITQFTEDEFKEqMSPTIGvdFKVKfmNVNRKKVKLTIFDTAGN-------------AHGIILVYDVTREETFNNIKNWLK 92 
                 6899***********************986589**99334444336777**********996.............57********************** PP

                 HHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHH CS
         Arf 106 alleeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlse 173
                 +    ++ +e++ l+++NK+Dl+e  + + l+   + ++  +++++  +++sa ++e++++++e ++ 
  EFC35538.1  93 ECDLYSTFEECVKLLIGNKIDLKEERKVS-LQ---DAQNFAKSNNMVYIETSAKTKENVDKAFEEVVY 156
                 **********************9765443.33...33444556788888999*******999998775 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.3   4.9e-09   6.7e-06       2      71 ..      12      91 ..      11     174 .. 0.70

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 4.9e-09
                EEEEESTTSSHHHHHHHHHTS..TEEESSSTTSSSSEEEEEEEETTEEEEEEECGG....C...........SSHHHHHHHHHHHHH CS
    MMR_HSR1  2 vaivGrpNvGKStLinaltge..kaivsdkpgtTrdinegrvklkgkeielvDtpG....l...........iegaseekglgkafl 71
                 ++vG + +GKS++i + t++  k ++s + g+  ++++ +v+ k+ ++++ Dt+G    +           +       +  k++l
  EFC35538.1 12 LVLVGDSATGKSSIITQFTEDefKEQMSPTIGVDFKVKFMNVNRKKVKLTIFDTAGnahgIilvydvtreetF-------NNIKNWL 91
                689*****************97778999999************999**********55441333222221110.......2222222 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   1.7   0.00012      0.17       2      56 ..      11      67 ..      10     154 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00012
                EEEEEESTTSSHHHHHHHHHTTSEEEEESTTSSSEEEEEEEEETT..EEEEEEE--- CS
      FeoB_N  2 tvalvGnpnvGkttlfnaltgakqkvgNwpGvtvekkegklklkg..keveivDlPG 56
                +++lvG+  +Gk++++ + t+ + k    p + v+ k   +++++   +++i D  G
  EFC35538.1 11 KLVLVGDSATGKSSIITQFTEDEFKEQMSPTIGVDFKVKFMNVNRkkVKLTIFDTAG 67
                679*****************9876666666666666666555555116667778766 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0    0.0013       1.8     102     122 ..      12      32 ..       4      45 .. 0.84
   2 !    9.6   0.8   0.00056      0.78      46      95 ..     102     152 ..      52     162 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0013
                  EEEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase 102 svlvGqSGvGKStLinallpe 122
                   vlvG S  GKS++i +++++
   EFC35538.1  12 LVLVGDSATGKSSIITQFTED 32 
                  69*************998775 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00056
                  T-EEEEEEE-GGG--HHH.HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHH CS
  RsgA_GTPase  46 giepvivlnKiDlleeee.eleelkeelealgyevllvsaktkegleelke 95 
                  +   +++ nKiDl ee++ +l++ ++  ++ ++  + +saktke++++  e
   EFC35538.1 102 ECVKLLIGNKIDLKEERKvSLQDAQNFAKSNNMVYIETSAKTKENVDKAFE 152
                  33445666*********9889999999999999***********9987655 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.1   5.6e-06    0.0077      28      64 ..       4      40 ..       1      58 [. 0.79

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 5.6e-06
       AAA_7 28 lllknkkpvllvGptGtGKtviikdllkkldkekyls 64
                + ++++ +++lvG++ tGK++ii+++++   ke++++
  EFC35538.1  4 KAFDHNFKLVLVGDSATGKSSIITQFTEDEFKEQMSP 40
                6678999******************877666566654 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.1   1.6e-05     0.022       5      60 ..      11      69 ..       7      86 .. 0.80
   2 ?    1.0   0.1      0.18   2.5e+02      74     110 ..     129     166 ..     110     171 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.6e-05
                EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG.....GGTT-SEEEETT-G CS
       SRPRB  5 avllvGlsdsGKTslftrLttdsvkktvtSq.essaalkv..ksekgskltliDfPGhe 60
                +++lvG s +GK s++t+ t+d++k+ +       +  k+   ++k+ klt+ D  G+ 
  EFC35538.1 11 KLVLVGDSATGKSSIITQFTEDEFKEQMSPTiGVDFKVKFmnVNRKKVKLTIFDTAGNA 69
                5799******************9887554444555566655467888899999999875 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.18
                 GGEEEEEEEEETTS-HHHHHHHH.HHHHHHHHHHHHHT CS
       SRPRB  74 sslkglvfvvDStidpkevkevA.Ellyeilliteklk 110
                 ++   +v++  S+  + +v +   E +y+il  t +l+
  EFC35538.1 129 AKSNNMVYIETSAKTKENVDKAFeEVVYQILNTTNLLE 166
                 44566788766666666665432389999998887665 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   9.9e-06     0.014      38      63 ..      12      37 ..       7      65 .. 0.79
   2 ?   -2.0   0.0       1.4     2e+03     119     152 ..      57      93 ..      46      96 .. 0.65

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 9.9e-06
        TniB 38 lllvGdsnnGKtmivekFarlhppek 63
                l+lvGds++GK++i+ +F++++ +e+
  EFC35538.1 12 LVLVGDSATGKSSIITQFTEDEFKEQ 37
                799****************9885543 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.4
        TniB 119 kvrvLiiD...EihnllagsarkqreflnalksLgne 152
                 kv++ i+D     h ++     +++e++n +k+   e
  EFC35538.1  57 KVKLTIFDtagNAHGIILVYDVTREETFNNIKNWLKE 93 
                 5666666622224555666667888889988876555 PP

>> Septin  Septin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.2   9.6e-06     0.013       4      72 ..       9      68 ..       6      99 .. 0.75
   2 ?   -1.8   0.1       1.1   1.5e+03     150     178 ..     130     159 ..     113     178 .. 0.55

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 9.6e-06
                EEEEEEEEBTTSSCCCCCCTTSSSS------------------S-EEEEEEEEETTCEEEEEEEE---B CS
      Septin  4 eftlmvvGesglGkttlintlfetdlieeekleeasekkkktveikkkkvvieedgvklnltviDtpgf 72
                +f l++vG+s++Gk+++i  + e++ +e+         ++ t+ ++ k + ++ +  k++lt+ Dt g 
  EFC35538.1  9 NFKLVLVGDSATGKSSIITQFTEDEFKEQ---------MSPTIGVDFKVKFMNVNRKKVKLTIFDTAGN 68
                799*************9987766555444.........3334555555556666667999999999884 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.1
                 SGGGS-HHHHH.HHHHHHHHHHHHTT---- CS
      Septin 150 KaDtltkeElk.efKkkireeleeeeikiy 178
                 K++ ++  E++ ++K+++ + +ee   +i 
  EFC35538.1 130 KSNNMVYIETSaKTKENVDKAFEEVVYQIL 159
                 444444433321334444444444433333 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   0.00013      0.18       1      78 [.      11      88 ..      11      97 .. 0.78
   2 ?    4.2   0.3     0.017        23     130     184 ..     112     167 ..     105     171 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00013
   Gtr1_RagA  1 kvLLmGksgsGKtsmrsiiF.dnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvg 78
                k++L+G s  GK+s+      d++  +   ++g+  +v+  +v + ++++l ++D  G  + +   +   +ee f+n++
  EFC35538.1 11 KLVLVGDSATGKSSIITQFTeDEFKEQMSPTIGVDFKVKFMNV-NRKKVKLTIFDTAGNAHGIILVYDVTREETFNNIK 88
                899***********98654313333444446777777777777.67899*********999998888999999999986 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.017
   Gtr1_RagA 130 eeifeerkeeireeieklekeeiqffaTSi.wdeslykAfssivqklipnldvlee 184
                  ++ eerk +++++ + ++++++ +  TS    e + kAf ++v+++   +++le+
  EFC35538.1 112 IDLKEERKVSLQDAQNFAKSNNMVYIETSAkTKENVDKAFEEVVYQILNTTNLLES 167
                 5667788888888888777778999999983578999*********9999999986 PP

>> PRP8_domainIV  PRP8 domain IV core
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   2.2e-05     0.031     154     228 ..      80     155 ..      30     157 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.2e-05
  PRP8_domainIV 154 kmvlfnlyddWlesissytafsrlililralkinkekakki.lkpdkevvvkehhlwptlsdeeWvevevklrdli 228
                    +   fn   +Wl++++ y++f+  + +l + ki+ ++ +k+ l+  ++   +++ ++   s+++ ++v+ ++++++
     EFC35538.1  80 REETFNNIKNWLKECDLYSTFEECVKLLIGNKIDLKEERKVsLQDAQNFAKSNNMVYIETSAKTKENVDKAFEEVV 155
                    56689999**************************876655527777788888888888889999999998888776 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   8.4e-05      0.12      27      47 ..      12      32 ..       4     130 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 8.4e-05
      AAA_16 27 vllsGesGvGKsslvrellra 47
                ++l+G+s++GKss+++++ + 
  EFC35538.1 12 LVLVGDSATGKSSIITQFTED 32
                579*************99974 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1348  (0.0751855); expected 358.6 (0.02)
Passed bias filter:                      662  (0.0369234); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 1286.51
//
Query:       EFC35539.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.4e-08   32.1   3.7    1.3e-07   31.3   3.7    1.5  1  ApoL      Apolipoprotein L
     0.0047   15.9   0.1     0.0064   15.4   0.1    1.1  1  DUF677    Protein of unknown function (DUF677)
  ------ inclusion threshold ------
      0.051   13.7   0.0      0.083   13.0   0.0    1.3  1  DUF1993   Domain of unknown function (DUF1993)


Domain annotation for each model (and alignments):
>> ApoL  Apolipoprotein L
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.3   3.7   2.2e-11   1.3e-07      76     183 ..     136     243 ..     132     326 .. 0.89

  Alignments for each domain:
  == domain 1  score: 31.3 bits;  conditional E-value: 2.2e-11
        ApoL  76 erIkkLralAdevdkvHrdctisnvvasstgavSgiLtilGlaLAPvtaGlSLvLsatGlgLGaaaavTsvstsiveessnssakaeasrlvststdkl 174
                 e Ik L +l ++++k  + + +++v    t +v   L + G++ AP+t G+SL+ s +G+g   + ++++v++si e ++ ++  + +++l + +t+++
  EFC35539.1 136 EIIKMLDNLIQSLEKKQQSTAKTKVKGTKTNIVGASLILGGIVAAPFTFGVSLIASGAGIGCVGVGTTATVAASIAEWKHAKKSAKSIQELLQRDTQAV 234
                 5799*******************************************************998888888999******9999999999999999998888 PP

        ApoL 175 kvvkevlee 183
                 + + + + e
  EFC35539.1 235 NAMIRKIYE 243
                 766544444 PP

>> DUF677  Protein of unknown function (DUF677)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.1   1.1e-06    0.0064     151     290 ..     137     279 ..     113     295 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 1.1e-06
      DUF677 151 vykeqvllleklrktkkkldk.klrniktkraisnvvfvaafvaVlvlSvvlaalaapavva.vagalavPleavgkwva..sawkkyeealkrqkeiv 245
                 + k +  l++ l+k+++   k k++  kt  + +++++ + ++a + + v l+a +a+ +   v g++a+   ++++w    +  k  +e l+r  ++v
  EFC35539.1 137 IIKMLDNLIQSLEKKQQSTAKtKVKGTKTNIVGASLILGGIVAAPFTFGVSLIASGAGIGCVgV-GTTATVAASIAEWKHakKSAKSIQELLQRDTQAV 234
                 4455666777777666554432666666666667788888888899999999999888665436.66666667788886644777888999******** PP

      DUF677 246 ssmekgievakkdvenisilverleseiksilktvefAvekeene 290
                 + m + i+ +  +   i + v ++  +  ++l+ ve  + +++++
  EFC35539.1 235 NAMIRKIYEQRLTDPYIDSRVMKIGNRNVNVLQFVESLTGHKHQD 279
                 ***********999*******************999988877655 PP

>> DUF1993  Domain of unknown function (DUF1993)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   1.4e-05     0.083       9     102 ..     137     240 ..     133     272 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.4e-05
                 HHHHHHHHHHHHHHHHCCHHHHC....HHHHHT--SSTT...S--HHHHHHHHHHHHHHHHCHHCT-GS-.....---S.-SSHHHHHHHHHHHHHHHH CS
     DUF1993   9 fikglknlsalLkkaeahaaakkid..peellearLapD...MlpLsfQvqiatdtakkavarlagkepp.....sledeektfadlrariaktialLe 97 
                 +ik+l nl + L+k ++  a++k++  + +++ a+L+       p++f v ++++ a  ++  + +++ +     ++++ +k+ +++++ +++  ++++
  EFC35539.1 137 IIKMLDNLIQSLEKKQQSTAKTKVKgtKTNIVGASLILGgivAAPFTFGVSLIASGAGIGCVGVGTTATVaasiaEWKHAKKSAKSIQELLQRDTQAVN 235
                 689************999999988743556*******9877799***************9999977655545566444444444444444444444444 PP

                 CS-GG CS
     DUF1993  98 svdpe 102
                 ++ ++
  EFC35539.1 236 AMIRK 240
                 43333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1044  (0.0582297); expected 358.6 (0.02)
Passed bias filter:                      641  (0.0357521); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2010.77
//
Query:       EFC35540.1  [L=224]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.5e-06   27.9   0.4    5.7e-06   26.8   0.4    1.6  1  GPS        GPCR proteolysis site, GPS, motif
    8.6e-05   22.0   2.7    8.6e-05   22.0   2.7    1.5  2  DAG1       Dystroglycan (Dystrophin-associated glycoprotein 1
  ------ inclusion threshold ------
      0.011   16.0   0.5      0.011   16.0   0.5    1.9  2  Shisa      Wnt and FGF inhibitory regulator
      0.026   14.6   1.9      0.091   12.8   0.0    2.2  2  CD20       CD20-like family
       0.04   13.8   1.2       0.04   13.8   1.2    2.1  2  Syndecan   Syndecan domain
       0.14   12.8   0.3       0.14   12.8   0.3    2.7  3  OAD_gamma  Oxaloacetate decarboxylase, gamma chain
        1.7    9.2   6.3        3.1    8.4   0.7    2.2  2  B_lectin   D-mannose binding lectin


Domain annotation for each model (and alignments):
>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.8   0.4   2.2e-09   5.7e-06       2      45 .]     101     153 ..     100     153 .. 0.87

  Alignments for each domain:
  == domain 1  score: 26.8 bits;  conditional E-value: 2.2e-09
         GPS   2 sCvfWdeeneetgsWsteGCel............tesdnknetvCsCnHLtsFAvL 45 
                 sCv++   +e+ ++W ++G e+             + + + ++ C  nHLtsF+v+
  EFC35540.1 101 SCVYY---EENSKEWKSDGMETeiknleihnladGNITLTLSILCNTNHLTSFSVI 153
                 8****...55689*******99999*******994444678899**********96 PP

>> DAG1  Dystroglycan (Dystrophin-associated glycoprotein 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.64   1.6e+03      44      85 ..      13      51 ..       6      60 .. 0.55
   2 !   22.0   2.7   3.4e-08   8.6e-05      36     175 ..      68     219 ..      55     223 .. 0.67

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.64
                XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        DAG1 44 sitkgsiiveftnntlklepcpkeqvaglskkildedgslre 85
                si   sii ++  nt    + +++ v+ +s  i++++ s ++
  EFC35540.1 13 SISLPSIISQYLQNT--DTSLKNDSVQVVS-SIAESKNSNSD 51
                455667777776665..3444555555444.34444444444 PP

  == domain 2  score: 22.0 bits;  conditional E-value: 3.4e-08
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXX.XXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXX CS
        DAG1  36 nsstitlksitkgsiiveftnntlklepcpkeqvaglskkildedgsl..reafkrale.Pelkltnisvvgssscrh.....lefiplnqleeiPsev 126
                 +s +it++++ k  i + f n tl +++    ++  +  +   ++ +    e+  + le  +l   ni+++ s  c+      ++ i+ n ++   +++
  EFC35540.1  68 SSEKITVQNLEK-PISLSFENVTLTVSSIETLNISCVYYEENSKEWKSdgMETEIKNLEiHNLADGNITLTLSILCNTnhltsFSVIDQNYKKAATKPT 165
                 567899999876.68899**********99999988754443333332112222333332578889******999975456556678877766665555 PP

                 XXXXX...XXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXX CS
        DAG1 127 astea...peedaeksseddvylhtvipav..vvaailliagiiamicyrkkrk 175
                 ++++    p +dae    + v + +++ av  v +++++i+ ii+++c+ +krk
  EFC35540.1 166 PQPAQsnqPTKDAEILQDNTVLIGAIVGAVggVCVIAVVISIIIIAVCLLRKRK 219
                 55544001444455555555666677778766677778899999******9998 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.53   1.4e+03      88      88 ..      63      63 ..      18     145 .. 0.63
   2 ?   16.0   0.5   4.3e-06     0.011      54     116 ..     156     220 ..     142     224 .] 0.64

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.53
       Shisa 88 i 88
                +
  EFC35540.1 63 L 63
                1 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 4.3e-06
       Shisa  54 ndeteeslktgreekekqlgsalevpkd....iyvpv.livktifivfvivgvvvivcccgclkkkqr 116
                 n++++++ +t+++ + +q ++  e+ +d    i++ v ++++ ++i+ vi +++++vc+ +   k ++
  EFC35540.1 156 NYKKAATKPTPQPAQSNQPTKDAEILQDntvlIGAIVgAVGGVCVIAVVISIIIIAVCLLR---KRKK 220
                 5666666666665555555555555566777655555245677888888888888888854...4333 PP

>> CD20  CD20-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.4      0.15     4e+02      41      83 ..      53      95 ..      38     128 .. 0.61
   2 ?   12.8   0.0   3.6e-05     0.091      78     156 .]     136     214 ..     124     214 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.15
        CD20 41 fiisGvlgiaaekrstkllvklslllnlvslvlalaGiillil 83
                ++is++++++  k s    ++++ l + +sl +  + + +++ 
  EFC35540.1 53 AVISSIVSLVLLKSSSSEKITVQNLEKPISLSFENVTLTVSSI 95
                4566666666666666665555555555555544444444444 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 3.6e-05
        CD20  78 iillilslalltsaeelkesesdltsstsrcsskesseeeesraycsslrslltgilavlliltilellvsllsailcc 156
                 + l+il   ++ ++++ ++++++   ++++ ++ +s++  ++ + ++ ++ l  +i++++  ++++ +++s+++ ++c+
  EFC35540.1 136 LTLSILCNTNHLTSFSVIDQNYKKAATKPTPQPAQSNQPTKDAEILQDNTVLIGAIVGAVGGVCVIAVVISIIIIAVCL 214
                 4566777777777888888888888889999999999999999999999999999**********************95 PP

>> Syndecan  Syndecan domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.5   3.8e+03      10      21 ..      52      63 ..      48      65 .. 0.66
   2 ?   13.8   1.2   1.6e-05      0.04       6      39 ..     184     222 ..     179     224 .] 0.63

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.5
    Syndecan 10 aaviggvvvgll 21
                aavi ++v  +l
  EFC35540.1 52 AAVISSIVSLVL 63
                677777665444 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 1.6e-05
    Syndecan   6 pevlaavigg.....vvvgllfaillvlflvYRmrKKDE 39 
                 + vl + i+g     +v+++++ i++++ ++ R rKK E
  EFC35540.1 184 NTVLIGAIVGavggvCVIAVVISIIIIAVCLLRKRKKEE 222
                 4555444443111114566778899999999******98 PP

>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1      0.44   1.1e+03      41      73 ..      30      59 ..      11      62 .. 0.55
   2 ?   12.8   0.3   5.5e-05      0.14      27      73 ..     149     195 ..     136     199 .. 0.87
   3 ?   -0.8   0.4      0.92   2.4e+03      13      27 ..     200     214 ..     196     223 .. 0.46

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.44
   OAD_gamma 41 kkakaaaaaaaaaaaaaeldddeelvAvIaaAi 73
                + +  + + +++ a   e +++   +AvI+  +
  EFC35540.1 30 SLKNDSVQVVSSIA---ESKNSNSDAAVISSIV 59
                43333333333333...4477888888888766 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 5.5e-05
   OAD_gamma  27 lfskiikkkakkkkkkakaaaaaaaaaaaaaeldddeelvAvIaaAi 73 
                  fs i + ++k+++k+ +++a+ +++++ a+ l+d++ l+ +I+ A+
  EFC35540.1 149 SFSVIDQNYKKAATKPTPQPAQSNQPTKDAEILQDNTVLIGAIVGAV 195
                 589999999999999999999999999888899**********9998 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.92
   OAD_gamma  13 vVFvvLilLslvisl 27 
                 v+ vv+ ++++++ l
  EFC35540.1 200 VIAVVISIIIIAVCL 214
                 333344444443333 PP

>> B_lectin  D-mannose binding lectin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   2.9    0.0021       5.3      32      94 ..      33      95 ..      22     101 .. 0.83
   2 ?    8.4   0.7    0.0012       3.1       5      63 ..      74     137 ..      72     163 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0021
    B_lectin 32 esksvvwstssssssakntvaqLldsGnLvlesssnseevlWqsfdhptdtllpgmklglnkk 94
                +++  v s+ ++s+++++ +a+++    Lvl +ss+se++  q  ++p    + +++l++++ 
  EFC35540.1 33 NDSVQVVSSIAESKNSNSDAAVISSIVSLVLLKSSSSEKITVQNLEKPISLSFENVTLTVSSI 95
                3355566777999999********************************999888888887765 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0012
    B_lectin   5 VaNrekPi..kdssgvlkisedgnLvl...lnesksvvwstssssssakntvaqLldsGnLvle 63 
                 V N ekPi  + ++ +l++s+  +L +   + e++s  w++   +++ kn  ++ l +Gn+ l+
  EFC35540.1  74 VQNLEKPIslSFENVTLTVSSIETLNIscvYYEENSKEWKSDGMETEIKNLEIHNLADGNITLT 137
                 8899****666667778888877787732246669******99999999999999999**9993 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1363  (0.0760221); expected 358.6 (0.02)
Passed bias filter:                      566  (0.031569); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.37s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 1241.76
//
Query:       EFC35541.1  [L=748]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      8e-61  201.1  39.3      4e-09   36.8   0.3   11.3 10  Sel1      Sel1 repeat
    3.5e-25   87.5   6.0    4.7e-08   32.6   0.0    4.7  4  DUF4116   Domain of unknown function (DUF4116)
    1.2e-08   35.0  18.5        1.1   10.0   0.2    8.7  9  TPR_6     Tetratricopeptide repeat
    1.3e-07   31.2  24.6     0.0021   18.0   0.1    9.7  9  TPR_2     Tetratricopeptide repeat
    2.3e-07   31.3   4.7        1.1    9.9   0.0    6.8  7  TPR_16    Tetratricopeptide repeat
    3.7e-06   26.5  32.5     0.0011   18.7   0.6    9.8 11  TPR_1     Tetratricopeptide repeat
    0.00064   19.7   0.7    0.00064   19.7   0.7    8.5  9  TPR_8     Tetratricopeptide repeat
     0.0014   18.9  15.1      0.027   14.7   0.2    6.7  9  TPR_12    Tetratricopeptide repeat
     0.0038   17.1   2.2        1.7    8.9   0.0    4.6  4  TPR_7     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.012   15.9  16.8        8.7    7.0   0.0    8.3  9  TPR_17    Tetratricopeptide repeat
      0.024   14.5   1.0       0.47   10.4   0.0    3.5  4  TPR_10    Tetratricopeptide repeat
      0.027   14.7  23.6       0.19   12.0   1.7    5.8  5  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
        6.8    6.4   6.1    1.1e+02    2.6   0.1    4.7  5  TAP_C     TAP C-terminal domain


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.3   0.00073         1       4      38 .]     387     415 ..     384     415 .. 0.81
   2 !   11.0   1.3   0.00039      0.53       2      38 .]     417     447 ..     416     447 .. 0.84
   3 !   17.8   0.0   2.9e-06    0.0039       1      38 []     448     488 ..     448     488 .. 0.80
   4 !   33.8   0.5   2.7e-11   3.7e-08       3      37 ..     491     523 ..     489     524 .. 0.92
   5 !   17.8   0.2   2.9e-06     0.004       2      38 .]     526     557 ..     525     557 .. 0.84
   6 !   17.4   0.0   3.9e-06    0.0054       2      30 ..     559     585 ..     558     587 .. 0.90
   7 !   31.8   0.1   1.2e-10   1.6e-07       2      38 .]     595     629 ..     594     629 .. 0.94
   8 !   15.7   0.4   1.3e-05     0.018       2      32 ..     631     655 ..     630     655 .. 0.90
   9 !   29.5   0.0     6e-10   8.3e-07       3      38 .]     664     698 ..     662     698 .. 0.90
  10 !   36.8   0.3   2.9e-12     4e-09       1      37 [.     699     733 ..     699     734 .. 0.94

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00073
        Sel1   4 myrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 ++rLG   ly+n     kD++ A  wy ++A+qG+
  EFC35541.1 387 QNRLG--VLYYNE----KDISNAAFWYDQSAKQGH 415
                 66777..444555....7****************9 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00039
        Sel1   2 eAmyrLG.mfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  A+++LG ++y  +n l++p     A +w+ k+AeqG+
  EFC35541.1 417 KAQFNLGlLYY--MNSLMEP-----AKHWFLKSAEQGY 447
                 59*****5555..9999665.....6**********96 PP

  == domain 3  score: 17.8 bits;  conditional E-value: 2.9e-06
        Sel1   1 aeAmyrLGmfylylnGl..gvpk.....DpekAiewyekAAeqGd 38 
                 a+A+++LG +y  ++ +  +          e+A+ wy k+AeqG+
  EFC35541.1 448 ADAQFNLGVVY--ETDQfvD--EserrsQLEQAFIWYMKSAEQGH 488
                 68******666..****653..4223566999************9 PP

  == domain 4  score: 33.8 bits;  conditional E-value: 2.7e-11
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 A+  L+  +ly++G+gv++D++k iewy k+AeqG
  EFC35541.1 491 AQGYLA--QLYEYGRGVERDYSKTIEWYTKSAEQG 523
                 77789*..999***********************9 PP

  == domain 5  score: 17.8 bits;  conditional E-value: 2.9e-06
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +++++L++++   +    ++D e A++w+ kAAe+G+
  EFC35541.1 526 SSQFNLALML---HL--YERDAETAFYWMGKAAENGH 557
                 7899999555...33..578****************8 PP

  == domain 6  score: 17.4 bits;  conditional E-value: 3.9e-06
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewy 30 
                 +A+++LG   lyl+G g+ kD++k++e +
  EFC35541.1 559 DAQFNLG--WLYLKGIGTVKDYSKGFEIL 585
                 7******..****************9865 PP

  == domain 7  score: 31.8 bits;  conditional E-value: 1.2e-10
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 e +++L+  y+y+ G g++k++++++e++ kAAe+G+
  EFC35541.1 595 EVLFNLA--YCYYQGFGTEKNIDLGLELFLKAAENGH 629
                 5579***..***************************8 PP

  == domain 8  score: 15.7 bits;  conditional E-value: 1.3e-05
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyek 32 
                 +A+y+ Gm+y       +++D++kA+ew+++
  EFC35541.1 631 AAQYNIGMIY------LEKQDYQKAFEWFKQ 655
                 69*****999......4789*********86 PP

  == domain 9  score: 29.5 bits;  conditional E-value: 6e-10
        Sel1   3 AmyrLGmfylylnGlg.vpkDpekAiewyekAAeqGd 38 
                 +++++++fy  +nG   v+kD+ kA+e++ ++AeqG+
  EFC35541.1 664 SLFQYALFY--YNGSHiVEKDYTKAFELFLRSAEQGH 698
                 789999667..****66*******************9 PP

  == domain 10  score: 36.8 bits;  conditional E-value: 2.9e-12
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 a A+y+L+  +ly++G g+++D++kA ew+ k+ e+G
  EFC35541.1 699 AQAQYNLA--LLYFKGIGIDQDYSKAKEWFLKSSENG 733
                 68******..777*********************998 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.3   1.5e-07   0.00021      11      47 ..     157     193 ..     156     195 .. 0.93
   2 !   26.6   0.4   2.6e-09   3.5e-06       2      47 ..     198     244 ..     198     255 .. 0.95
   3 !   22.7   0.0   4.4e-08   6.1e-05       1      49 []     269     317 ..     269     317 .. 0.95
   4 !   32.6   0.0   3.4e-11   4.7e-08       3      49 .]     296     342 ..     294     351 .. 0.97

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 1.5e-07
     DUF4116  11 kngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 ++ s++k+l +e+ n+  +v+ A+  +g +l+y++ e
  EFC35541.1 157 NFESNYKNLKSEFLNNESVVMSALSEDGLNLKYVPTE 193
                 67899******************************88 PP

  == domain 2  score: 26.6 bits;  conditional E-value: 2.6e-09
     DUF4116   2 rEivleavkkngsalkyl.seeLknDkeivlkAvkqngtalsyasee 47 
                 r ++l a+ +n s+++++ s+++k  k+++ +Avk++  +++ +++ 
  EFC35541.1 198 RNVILRAINQNASSYQFIrSKKWKYSKNVMEQAVKKDARVIELIPKQ 244
                 789***************************************99985 PP

  == domain 3  score: 22.7 bits;  conditional E-value: 4.4e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D E +++ v ++g +l+y+ + Lk + e+v + vk+ g+al +as+ +r
  EFC35541.1 269 DLEKMKKMVNIDGTYLQYATDTLKGNVELVTESVKNRGIALQFASNTMR 317
                 67889****************************************9876 PP

  == domain 4  score: 32.6 bits;  conditional E-value: 3.4e-11
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 E+v+e vk+ g al+++s+ ++++ +i+  Av qn+ a+ +++++L+
  EFC35541.1 296 ELVTESVKNRGIALQFASNTMRSNYDICYLAVSQNPEAIQFVDDSLQ 342
                 99******************************************996 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       2.9     4e+03       5      19 ..     389     403 ..     389     404 .. 0.86
   2 ?    1.5   0.1      0.41   5.7e+02       2      12 ..     418     428 ..     417     437 .. 0.83
   3 ?    0.1   0.1       1.2   1.6e+03       1      13 [.     449     462 ..     449     501 .. 0.66
   4 ?   -0.2   0.0       1.4     2e+03       2      15 ..     545     557 ..     544     559 .. 0.81
   5 !    8.0   0.0    0.0035       4.8       1      26 [.     559     588 ..     559     589 .. 0.91
   6 ?    6.4   0.0     0.011        15       1      17 [.     595     615 ..     595     627 .. 0.72
   7 !   10.0   0.2   0.00081       1.1       2      21 ..     632     651 ..     631     656 .. 0.86
   8 ?    3.2   0.0      0.12   1.6e+02       2      23 ..     664     690 ..     663     694 .. 0.91
   9 !    9.6   0.1    0.0011       1.5       1      21 [.     700     724 ..     700     728 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 2.9
                 HHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkA 19 
                 +l+ +y++ +d ++A
  EFC35541.1 389 RLGVLYYNEKDISNA 403
                 79******8898887 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.41
                 HHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrk 12 
                 A+++l+l+y++
  EFC35541.1 418 AQFNLGLLYYM 428
                 99*******96 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHH.H CS
       TPR_6   1 dAlyklalsyrk.l 13 
                 dA+++l+  y+  +
  EFC35541.1 449 DAQFNLGVVYETdQ 462
                 78999999887544 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrklgd 15 
                 A+y+++++ +++  
  EFC35541.1 545 AFYWMGKAAENG-H 557
                 99*****99986.5 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0035
                 HHHHHHHHHHHHH....HHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtdkAlealerl 26 
                 dA+++l+++y+k+    +d++k  e+l +l
  EFC35541.1 559 DAQFNLGWLYLKGigtvKDYSKGFEILSKL 588
                 8***********999999999999999887 PP

  == domain 6  score: 6.4 bits;  conditional E-value: 0.011
                 HHHHHHHHHHHHH....HHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtd 17 
                 ++l++la++y+++    ++ d
  EFC35541.1 595 EVLFNLAYCYYQGfgteKNID 615
                 68*********9865555555 PP

  == domain 7  score: 10.0 bits;  conditional E-value: 0.00081
                 HHHHHHHHHHH.HHHHHHHHH CS
       TPR_6   2 Alyklalsyrk.lgdtdkAle 21 
                 A+y++++ y++ + d++kA e
  EFC35541.1 632 AQYNIGMIYLEkQ-DYQKAFE 651
                 99********955.****965 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.12
                 HHHHHHHHHHHH.....HHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl.....gdtdkAleal 23 
                 +l++ al y+++     +d++kA e++
  EFC35541.1 664 SLFQYALFYYNGshiveKDYTKAFELF 690
                 69*********99**********9987 PP

  == domain 9  score: 9.6 bits;  conditional E-value: 0.0011
                 HHHHHHHHHHHHH....HHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtdkAle 21 
                 +A+y+lal+y+k+    +d++kA+e
  EFC35541.1 700 QAQYNLALLYFKGigidQDYSKAKE 724
                 69**********99**99**9*997 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       7.3     1e+04      13      31 ..     216     234 ..     212     234 .. 0.81
   2 !    9.3   0.2   0.00099       1.4       4      29 ..     387     412 ..     384     413 .. 0.89
   3 ?    3.6   0.1     0.064        88       2      28 ..     417     443 ..     416     445 .. 0.82
   4 ?    0.2   0.0       0.8   1.1e+03       1      12 [.     448     459 ..     448     469 .. 0.81
   5 ?   -0.0   0.0      0.93   1.3e+03       2      13 ..     559     570 ..     558     570 .. 0.87
   6 ?    4.0   0.2     0.047        65       2      13 ..     595     606 ..     594     607 .. 0.91
   7 !   18.0   0.1   1.5e-06    0.0021       3      27 ..     632     656 ..     630     663 .. 0.91
   8 ?    0.8   0.0      0.51   7.1e+02      13      29 ..     679     695 ..     676     696 .. 0.79
   9 ?    1.6   1.3      0.29     4e+02       3      26 ..     701     728 ..     699     731 .. 0.59

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 7.3
       TPR_2  13 klgdyeeAleafekAleld 31 
                 ++++++  ++ +e+A++ d
  EFC35541.1 216 RSKKWKYSKNVMEQAVKKD 234
                 6788888999999999875 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00099
       TPR_2   4 lynlGlayyklgdyeeAleafekAle 29 
                  ++lG +yy+ +d   A+ +++++ +
  EFC35541.1 387 QNRLGVLYYNEKDISNAAFWYDQSAK 412
                 689*******************9865 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.064
       TPR_2   2 ealynlGlayyklgdyeeAleafekAl 28 
                 +a +nlGl+yy +   e A+++f k+ 
  EFC35541.1 417 KAQFNLGLLYYMNSLMEPAKHWFLKSA 443
                 689********9988888888887765 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.8
       TPR_2   1 aealynlGlayy 12 
                 a+a +nlG +y+
  EFC35541.1 448 ADAQFNLGVVYE 459
                 7899******97 PP

  == domain 5  score: -0.0 bits;  conditional E-value: 0.93
       TPR_2   2 ealynlGlayyk 13 
                 +a +nlG++y+k
  EFC35541.1 559 DAQFNLGWLYLK 570
                 589*******86 PP

  == domain 6  score: 4.0 bits;  conditional E-value: 0.047
       TPR_2   2 ealynlGlayyk 13 
                 e+l+nl+++yy+
  EFC35541.1 595 EVLFNLAYCYYQ 606
                 89*********7 PP

  == domain 7  score: 18.0 bits;  conditional E-value: 1.5e-06
       TPR_2   3 alynlGlayyklgdyeeAleafekA 27 
                 a yn+G++y++++dy++A e+f+++
  EFC35541.1 632 AQYNIGMIYLEKQDYQKAFEWFKQC 656
                 88********************997 PP

  == domain 8  score: 0.8 bits;  conditional E-value: 0.51
       TPR_2  13 klgdyeeAleafekAle 29 
                   +dy +A e+f ++ e
  EFC35541.1 679 VEKDYTKAFELFLRSAE 695
                 57899999999998765 PP

  == domain 9  score: 1.6 bits;  conditional E-value: 0.29
       TPR_2   3 alynlGlayyk....lgdyeeAleafek 26 
                 a ynl+l+y+k     +dy +A+e+f k
  EFC35541.1 701 AQYNLALLYFKgigiDQDYSKAKEWFLK 728
                 6666666666522223677777777766 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       5.5   7.6e+03      43      61 ..     323     341 ..     322     344 .. 0.84
   2 ?    4.8   0.1     0.033        45       7      53 ..     394     435 ..     388     446 .. 0.75
   3 ?    1.5   0.0      0.36   4.9e+02      24      45 ..     440     459 ..     437     468 .. 0.79
   4 ?   -0.3   0.0       1.3   1.7e+03      33      46 ..     557     570 ..     550     578 .. 0.83
   5 ?    2.1   0.0      0.23   3.2e+02      34      63 ..     594     627 ..     590     629 .. 0.87
   6 !    9.9   0.0   0.00082       1.1      12      58 ..     613     654 ..     610     664 .. 0.85
   7 !    8.5   0.1    0.0023       3.2      11      47 ..     681     712 ..     669     729 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 5.5
      TPR_16  43 aalrqgrlaeAaalyraal 61 
                 ++l+ +  +eA+++++  l
  EFC35541.1 323 CYLAVSQNPEAIQFVDDSL 341
                 89999999*****999766 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.033
      TPR_16   7 alragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeA 53 
                 +++ +d   Aa  +++  k++     +  A+++lg++++ ++ +++A
  EFC35541.1 394 YYNEKDISNAAFWYDQSAKQG-----HGKAQFNLGLLYYMNSLMEPA 435
                 555555555555577777777.....999************999988 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.36
      TPR_16  24 lkrdpssPdaaeAllllgdaal 45 
                 lk++  +   a+A+++lg+++ 
  EFC35541.1 440 LKSA--EQGYADAQFNLGVVYE 459
                 6666..3569*********996 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 1.3
      TPR_16  33 aaeAllllgdaalr 46 
                 + +A+++lg+++l+
  EFC35541.1 557 HTDAQFNLGWLYLK 570
                 789********985 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.23
      TPR_16  34 aeAllllgdaalrq....grlaeAaalyraalra 63 
                  e l++l+ ++++     ++ ++ ++l+++a+++
  EFC35541.1 594 SEVLFNLAYCYYQGfgteKNIDLGLELFLKAAEN 627
                 5789*********999999999999999999876 PP

  == domain 6  score: 9.9 bits;  conditional E-value: 0.00082
      TPR_16  12 dyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyr 58 
                 + d  ++++  a +++     + +A+++ g ++l+++++++A ++++
  EFC35541.1 613 NIDLGLELFLKAAENG-----HIAAQYNIGMIYLEKQDYQKAFEWFK 654
                 5666778888888888.....889*********************97 PP

  == domain 7  score: 8.5 bits;  conditional E-value: 0.0023
      TPR_16  11 gdyddAaaaleaalkrdpssPdaaeAllllgdaalrq 47 
                 +dy++A +++ +  +++     +a+A+++l++++++ 
  EFC35541.1 681 KDYTKAFELFLRSAEQG-----HAQAQYNLALLYFKG 712
                 68888888888888888.....***********9976 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       2.7   3.7e+03      10      31 ..     323     344 ..     322     346 .. 0.78
   2 !    7.8   0.2    0.0021       2.9       5      27 ..     388     410 ..     384     413 .. 0.89
   3 ?    5.2   0.1     0.014        20       2      26 ..     417     441 ..     416     445 .. 0.85
   4 ?    1.5   0.0      0.21   2.9e+02       1      12 [.     448     459 ..     448     460 .. 0.91
   5 ?   -1.7   0.0       2.2     3e+03      16      27 ..     508     519 ..     506     521 .. 0.84
   6 ?    0.9   0.0      0.33   4.6e+02       2      13 ..     559     570 ..     558     570 .. 0.89
   7 ?    3.4   0.2     0.054        74       2      13 ..     595     606 ..     594     606 .. 0.89
   8 !   18.7   0.6     8e-07    0.0011       3      27 ..     632     656 ..     630     660 .. 0.93
   9 ?   -1.4   0.0       1.8   2.4e+03      22      30 ..     681     689 ..     679     693 .. 0.72
  10 ?    4.2   0.5     0.029        40       1      13 [.     699     711 ..     699     712 .. 0.93
  11 ?   -2.1   0.0       2.9   4.1e+03      16      26 ..     718     728 ..     717     729 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.7
                 HHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1  10 ayfklgkydeAleyyekALeln 31 
                 +y+   +  eA+++ +  L+ n
  EFC35541.1 323 CYLAVSQNPEAIQFVDDSLQQN 344
                 8999999999999877777766 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0021
                 HHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekA 27 
                 ++lG++y++ ++   A   y++ 
  EFC35541.1 388 NRLGVLYYNEKDISNAAFWYDQS 410
                 89***************999985 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.014
                 HHHHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyek 26 
                 ka +nlG++y+ +   + A   + k
  EFC35541.1 417 KAQFNLGLLYYMNSLMEPAKHWFLK 441
                 789********99999999888876 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.21
                 HHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayf 12 
                 a+a +nlG++y 
  EFC35541.1 448 ADAQFNLGVVYE 459
                 799*******95 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 2.2
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 +y + +e y k 
  EFC35541.1 508 DYSKTIEWYTKS 519
                 89999****996 PP

  == domain 6  score: 0.9 bits;  conditional E-value: 0.33
                 HHHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfk 13 
                 +a +nlG +y+k
  EFC35541.1 559 DAQFNLGWLYLK 570
                 6899******97 PP

  == domain 7  score: 3.4 bits;  conditional E-value: 0.054
                 HHHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfk 13 
                 ++l+nl+++y++
  EFC35541.1 595 EVLFNLAYCYYQ 606
                 789*******96 PP

  == domain 8  score: 18.7 bits;  conditional E-value: 8e-07
                 HHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekA 27 
                 a yn+G++y+++++y++A e ++++
  EFC35541.1 632 AQYNIGMIYLEKQDYQKAFEWFKQC 656
                 89********************996 PP

  == domain 9  score: -1.4 bits;  conditional E-value: 1.8
                 HHHHHHHHH CS
       TPR_1  22 eyyekALel 30 
                 ++y kA el
  EFC35541.1 681 KDYTKAFEL 689
                 677777766 PP

  == domain 10  score: 4.2 bits;  conditional E-value: 0.029
                 HHHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayfk 13 
                 a+a ynl+++yfk
  EFC35541.1 699 AQAQYNLALLYFK 711
                 7899*******98 PP

  == domain 11  score: -2.1 bits;  conditional E-value: 2.9
                 -HHHHHHHHHH CS
       TPR_1  16 kydeAleyyek 26 
                 +y +A e + k
  EFC35541.1 718 DYSKAKEWFLK 728
                 78899888866 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.035        48       5      27 ..     388     410 ..     387     412 .. 0.90
   2 ?    1.2   0.1      0.42   5.7e+02       2      27 ..     417     442 ..     416     444 .. 0.82
   3 ?   -1.6   0.0       3.1   4.3e+03       1      12 [.     448     459 ..     448     461 .. 0.87
   4 ?   -2.9   0.1       8.3   1.1e+04      17      27 ..     473     483 ..     472     485 .. 0.80
   5 ?   -0.0   0.0      0.99   1.4e+03       2      13 ..     559     570 ..     558     571 .. 0.86
   6 ?   -0.0   0.1         1   1.4e+03       2      13 ..     595     606 ..     594     607 .. 0.86
   7 !   19.7   0.7   4.6e-07   0.00064       3      27 ..     632     656 ..     630     657 .. 0.95
   8 ?   -3.0   0.0       8.9   1.2e+04      15      25 ..     681     691 ..     680     694 .. 0.66
   9 ?    3.1   1.2     0.097   1.3e+02       1      27 [.     699     729 ..     699     732 .. 0.70

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.035
                 HHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyeka 27 
                 ++lg +y + +d+ +A  +y + 
  EFC35541.1 388 NRLGVLYYNEKDISNAAFWYDQS 410
                 689**************999886 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.42
                 CHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyeka 27 
                 +a +nlg++y     +e Ak ++ k 
  EFC35541.1 417 KAQFNLGLLYYMNSLMEPAKHWFLKS 442
                 6889******9888888888888876 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 3.1
                 CCHHHHHHHHHH CS
       TPR_8   1 aeayynlgsiyl 12 
                 a+a +nlg +y+
  EFC35541.1 448 ADAQFNLGVVYE 459
                 6899*****997 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 8.3
                 HHHHHHHHHHH CS
       TPR_8  17 yeeAkeyyeka 27 
                 +e+A  +y+k 
  EFC35541.1 473 LEQAFIWYMKS 483
                 79999999997 PP

  == domain 5  score: -0.0 bits;  conditional E-value: 0.99
                 CHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylk 13 
                 +a +nlg++ylk
  EFC35541.1 559 DAQFNLGWLYLK 570
                 6889******86 PP

  == domain 6  score: -0.0 bits;  conditional E-value: 1
                 CHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylk 13 
                 e+++nl+++y +
  EFC35541.1 595 EVLFNLAYCYYQ 606
                 799******975 PP

  == domain 7  score: 19.7 bits;  conditional E-value: 4.6e-07
                 HHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyeka 27 
                 a yn+g+iyl+++dy++A e+++++
  EFC35541.1 632 AQYNIGMIYLEKQDYQKAFEWFKQC 656
                 78**********************9 PP

  == domain 8  score: -3.0 bits;  conditional E-value: 8.9
                 T-HHHHHHHHH CS
       TPR_8  15 gdyeeAkeyye 25 
                 +dy +A e + 
  EFC35541.1 681 KDYTKAFELFL 691
                 57777777665 PP

  == domain 9  score: 3.1 bits;  conditional E-value: 0.097
                 CCHHHHHHHHHHH....TT-HHHHHHHHHHH CS
       TPR_8   1 aeayynlgsiylk....lgdyeeAkeyyeka 27 
                 a+a ynl+++y+k     +dy +Ake++ k 
  EFC35541.1 699 AQAQYNLALLYFKgigiDQDYSKAKEWFLKS 729
                 6788899998865333336888888888886 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       2.5   3.5e+03      12      33 ..     323     344 ..     315     348 .. 0.61
   2 ?    0.6   0.0      0.52   7.2e+02      46      71 ..     417     442 ..     387     445 .. 0.80
   3 ?   -1.2   0.0       1.8   2.6e+03      43      56 ..     446     459 ..     440     464 .. 0.80
   4 ?    1.2   0.2      0.34   4.7e+02       5      36 ..     450     483 ..     446     504 .. 0.52
   5 ?   -1.7   0.1       2.7   3.7e+03      46      58 ..     526     538 ..     506     555 .. 0.55
   6 ?   -1.9   0.2       3.2   4.4e+03      31      31 ..     554     554 ..     526     570 .. 0.49
   7 ?   -1.9   0.0       3.1   4.3e+03      45      57 ..     594     606 ..     577     612 .. 0.79
   8 !   14.7   0.2     2e-05     0.027      43      71 ..     628     656 ..     595     657 .. 0.80
   9 !    6.2   0.1    0.0092        13      17      71 ..     681     729 ..     677     732 .. 0.67

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2.5
      TPR_12  12 vlrrlgrydeAlellekaleia 33 
                 ++++  +  eA+++ + +l++ 
  EFC35541.1 323 CYLAVSQNPEAIQFVDDSLQQN 344
                 4555555556666666665554 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.52
      TPR_12  46 ttlrnLgrlyralgryeeAlelleea 71 
                  +++nLg ly++    e A  ++ ++
  EFC35541.1 417 KAQFNLGLLYYMNSLMEPAKHWFLKS 442
                 57899999999988888887777666 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.8
      TPR_12  43 ltattlrnLgrlyr 56 
                 ++a +++nLg +y+
  EFC35541.1 446 GYADAQFNLGVVYE 459
                 57899999999994 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.34
      TPR_12   5 alnnlaavlrrlgrydeAlel..lekaleiarrl 36 
                 a+ nl++v+   +  de+++   le+a   + ++
  EFC35541.1 450 AQFNLGVVYETDQFVDESERRsqLEQAFIWYMKS 483
                 5556777777777777776531144444444444 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 2.7
      TPR_12  46 ttlrnLgrlyral 58 
                 ++++nL+ ++++ 
  EFC35541.1 526 SSQFNLALMLHLY 538
                 5666777775433 PP

  == domain 6  score: -1.9 bits;  conditional E-value: 3.2
      TPR_12  31 e 31 
                 e
  EFC35541.1 554 E 554
                 1 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 3.1
      TPR_12  45 attlrnLgrlyra 57 
                 +++l+nL+ +y++
  EFC35541.1 594 SEVLFNLAYCYYQ 606
                 5678888888875 PP

  == domain 8  score: 14.7 bits;  conditional E-value: 2e-05
      TPR_12  43 ltattlrnLgrlyralgryeeAlelleea 71 
                 + +++++n+g++y++  +y++A e+++++
  EFC35541.1 628 GHIAAQYNIGMIYLEKQDYQKAFEWFKQC 656
                 46889999999999999999999999986 PP

  == domain 9  score: 6.2 bits;  conditional E-value: 0.0092
      TPR_12  17 grydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleea 71 
                 ++y++A+el+ ++ e+  +    ++ l++ +  ++g+ +    +y +A e++ ++
  EFC35541.1 681 KDYTKAFELFLRSAEQGHAQ--AQYNLALLYFKGIGIDQ----DYSKAKEWFLKS 729
                 57777777777777777666..66666666666666665....777777777665 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       8.7   1.2e+04       3      19 ..     388     404 ..     388     411 .. 0.73
   2 ?    0.6   0.1      0.55   7.6e+02       4      26 ..     494     520 ..     493     532 .. 0.88
   3 !    8.9   0.0    0.0012       1.7       3      24 ..     634     655 ..     634     665 .. 0.85
   4 ?    3.0   0.0     0.092   1.3e+02       3      24 ..     703     728 ..     703     734 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 8.7
       TPR_7   3 lnLarlysrlGdyeeAi 19 
                 ++L++ly ++ d ++A+
  EFC35541.1 388 NRLGVLYYNEKDISNAA 404
                 57999998887777776 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.55
       TPR_7   4 nLarlysr....lGdyeeAielyeqsL 26 
                 +La+ly+     ++dy++ ie y++s 
  EFC35541.1 494 YLAQLYEYgrgvERDYSKTIEWYTKSA 520
                 79999999999999****999999965 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0012
       TPR_7   3 lnLarlysrlGdyeeAielyeq 24 
                 +n++ +y + +dy++A e ++q
  EFC35541.1 634 YNIGMIYLEKQDYQKAFEWFKQ 655
                 599*****************99 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.092
       TPR_7   3 lnLarlysr....lGdyeeAielyeq 24 
                 +nLa ly++    ++dy++A e + +
  EFC35541.1 703 YNLALLYFKgigiDQDYSKAKEWFLK 728
                 59******************999877 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       3.7     5e+03      12      28 ..     383     399 ..     382     404 .. 0.77
   2 ?   -0.6   0.1       1.7   2.4e+03      14      26 ..     417     429 ..     413     430 .. 0.82
   3 ?    2.2   0.0      0.22     3e+02      11      25 ..     446     469 ..     439     477 .. 0.71
   4 ?   -2.2   0.0       5.3   7.3e+03      12      23 ..     488     499 ..     480     504 .. 0.74
   5 ?    1.6   0.0      0.33   4.6e+02      13      25 ..     558     570 ..     553     579 .. 0.86
   6 ?    7.0   0.0    0.0063       8.7      12      24 ..     593     605 ..     590     618 .. 0.85
   7 ?    2.8   0.1      0.14   1.9e+02      16      32 ..     633     649 ..     620     651 .. 0.87
   8 ?    3.9   0.0      0.06        83      10      25 ..     659     674 ..     655     688 .. 0.87
   9 ?    1.0   0.0      0.52   7.2e+02      11      24 ..     697     710 ..     689     724 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3.7
      TPR_17  12 nadaynnLAelllknGd 28 
                 nad  n L++l+++ +d
  EFC35541.1 383 NADDQNRLGVLYYNEKD 399
                 6666689*****98766 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.7
      TPR_17  14 daynnLAelllkn 26 
                 +a +nL+ l+++n
  EFC35541.1 417 KAQFNLGLLYYMN 429
                 5679******976 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.22
      TPR_17  11 nnadaynnLAelll.........k 25 
                  +ada +nL+++++         +
  EFC35541.1 446 GYADAQFNLGVVYEtdqfvdeseR 469
                 689**********85555555444 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 5.3
      TPR_17  12 nadaynnLAell 23 
                 +a+a  +LA+l+
  EFC35541.1 488 HANAQGYLAQLY 499
                 677777899988 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.33
      TPR_17  13 adaynnLAelllk 25 
                  da +nL++l+lk
  EFC35541.1 558 TDAQFNLGWLYLK 570
                 6888*******85 PP

  == domain 6  score: 7.0 bits;  conditional E-value: 0.0063
      TPR_17  12 nadaynnLAelll 24 
                 ++++++nLA++++
  EFC35541.1 593 DSEVLFNLAYCYY 605
                 89*********98 PP

  == domain 7  score: 2.8 bits;  conditional E-value: 0.14
      TPR_17  16 ynnLAelllknGdlmtA 32 
                  +n + ++l++ d+++A
  EFC35541.1 633 QYNIGMIYLEKQDYQKA 649
                 69*************99 PP

  == domain 8  score: 3.9 bits;  conditional E-value: 0.06
      TPR_17  10 PnnadaynnLAelllk 25 
                 +n++++++++A ++++
  EFC35541.1 659 HNDPNSLFQYALFYYN 674
                 69************95 PP

  == domain 9  score: 1.0 bits;  conditional E-value: 0.52
      TPR_17  11 nnadaynnLAelll 24 
                  +a a +nLA l+ 
  EFC35541.1 697 GHAQAQYNLALLYF 710
                 578999******96 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1       1.2   1.7e+03       5      21 ..     387     403 ..     387     410 .. 0.81
   2 ?   -3.0   0.0       5.4   7.5e+03       7      14 ..     453     461 ..     448     468 .. 0.71
   3 ?   10.4   0.0   0.00034      0.47       3      28 ..     631     656 ..     630     656 .. 0.94
   4 ?   -1.5   0.1       1.9   2.6e+03       2      13 ..     699     710 ..     699     711 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.2
      TPR_10   5 lnNLanalrqrgrydeA 21 
                 +n L++++++ ++   A
  EFC35541.1 387 QNRLGVLYYNEKDISNA 403
                 699******98877666 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 5.4
      TPR_10   7 NLanal.rq 14 
                 NL++++ ++
  EFC35541.1 453 NLGVVYeTD 461
                 9****9444 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00034
      TPR_10   3 sslnNLanalrqrgrydeAealleea 28 
                 +++ N+++++ + ++y++A ++++++
  EFC35541.1 631 AAQYNIGMIYLEKQDYQKAFEWFKQC 656
                 6899*******************997 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 1.9
      TPR_10   2 AsslnNLanalr 13 
                 A ++ NLa +++
  EFC35541.1 699 AQAQYNLALLYF 710
                 67999****996 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.3    0.0058         8       3      49 ..     398     442 ..     380     458 .. 0.90
   2 ?   -0.1   0.2      0.79   1.1e+03      19      54 ..     521     557 ..     484     571 .. 0.68
   3 ?    4.9   2.2     0.023        32      19      77 ..     590     651 ..     576     656 .. 0.64
   4 ?    9.2   1.3     0.001       1.4      18      66 ..     625     672 ..     608     674 .. 0.81
   5 ?   12.0   1.7   0.00014      0.19      20      68 ..     659     711 ..     656     716 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0058
                 T-HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3   3 nnyknAiflaerllaaetespedayllAlclylngqykrAyellrka 49 
                 +++ nA f+++     ++ + ++ + l+l +y n+  + A +++ k+
  EFC35541.1 398 KDISNAAFWYDQSA--KQGHGKAQFNLGLLYYMNSLMEPAKHWFLKS 442
                 67899******999..8999999999****************99887 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.79
                 HH--HHHHHHHHHHH.HHTT-HHHHHHHHHCTSHHHC CS
      ANAPC3  19 etespedayllAlcl.ylngqykrAyellrkaklnsk 54 
                 e+   ++ + lAl l +   + ++A+++  ka +n++
  EFC35541.1 521 EQGFVSSQFNLALMLhLYERDAETAFYWMGKAAENGH 557
                 5566666666666541445668999999999944433 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.023
                 HH--HHHHHHHHHHHHH....TT-HHHHHHHHHCTSHHHC-HHHHHHHHHHHHHTT-HHHHHH CS
      ANAPC3  19 etespedayllAlclyl....ngqykrAyellrkaklnskslgcrylfAqcllkLkkyeeAia 77 
                  te++e ++ lA+c+y+     ++ +  +el+ ka  ++ ++++ y ++  +l+ + y++A  
  EFC35541.1 590 PTEDSEVLFNLAYCYYQgfgtEKNIDLGLELFLKA-AENGHIAAQYNIGMIYLEKQDYQKAFE 651
                 56666777777888886444456677777777777.666777777777777777777777654 PP

  == domain 4  score: 9.2 bits;  conditional E-value: 0.001
                 HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHHHHH CS
      ANAPC3  18 aetespedayllAlclylngqykrAyellrkaklnskslgcrylfAqcl 66 
                 ae+ +  + y  +  +++ ++y++A+e+++++ + ++++++++ +A  +
  EFC35541.1 625 AENGHIAAQYNIGMIYLEKQDYQKAFEWFKQC-EVHNDPNSLFQYALFY 672
                 6677777778889999999*************.8888889999888765 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 0.00014
                 H--HHHHHHHHHHHHH.....TT-HHHHHHHHHCTSHHHC-HHHHHHHHHHHHH CS
      ANAPC3  20 tespedayllAlclyl.....ngqykrAyellrkaklnskslgcrylfAqcllk 68 
                 +++p++++ +Al +y+      ++y++A+el+ ++  +  + ++ y +A  ++k
  EFC35541.1 659 HNDPNSLFQYALFYYNgshivEKDYTKAFELFLRS-AEQGHAQAQYNLALLYFK 711
                 689************944444566********999.788999****99998886 PP

>> TAP_C  TAP C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1     0.077   1.1e+02       1      24 [.     244     267 ..     244     268 .. 0.90
   2 ?   -1.1   0.1       1.1   1.5e+03      21      42 ..     393     414 ..     391     415 .. 0.88
   3 ?    0.6   0.1      0.32   4.4e+02      26      40 ..     644     658 ..     640     661 .. 0.84
   4 ?    1.5   0.0      0.17   2.3e+02      26      42 ..     681     697 ..     677     698 .. 0.85
   5 ?   -3.1   0.0       4.6   6.3e+03      27      41 ..     718     732 ..     716     734 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.077
                 HHHHHHHHHH-B-HHHHHHHHSST CS
       TAP_C   1 emvqafstqtgMnlewsqkcLeqn 24 
                 +mv+ +  ++ ++le ++k  ++ 
  EFC35541.1 244 QMVMYLNFESDLKLELPKKTIQDY 267
                 8****************9987776 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.1
                 HSSTTT-HHHHHHHHHHHG..G CS
       TAP_C  21 LeqnnWdyerAlqvFeelkakg 42 
                 L+ n+ d+++A+  + ++ ++g
  EFC35541.1 393 LYYNEKDISNAAFWYDQSAKQG 414
                 899*********9999999876 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.32
                 T-HHHHHHHHHHHG. CS
       TAP_C  26 WdyerAlqvFeelka 40 
                  dy++A++ F++  +
  EFC35541.1 644 QDYQKAFEWFKQCEV 658
                 59********99765 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.17
                 T-HHHHHHHHHHHG..G CS
       TAP_C  26 WdyerAlqvFeelkakg 42 
                  dy++A++ F  + ++g
  EFC35541.1 681 KDYTKAFELFLRSAEQG 697
                 6*********9998776 PP

  == domain 5  score: -3.1 bits;  conditional E-value: 4.6
                 -HHHHHHHHHHHG.. CS
       TAP_C  27 dyerAlqvFeelkak 41 
                 dy++A + F ++ ++
  EFC35541.1 718 DYSKAKEWFLKSSEN 732
                 99***9999988755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (748 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       841  (0.0469072); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.62u 0.27s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 4731.30
//
Query:       EFC35542.1  [L=368]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.6e-77  248.0  13.9    3.9e-05   23.3   0.0   15.0 15  LRR_6        Leucine Rich repeat
    2.1e-49  164.6  15.9    2.1e-06   28.0   0.1    8.8 10  LRR_4        Leucine Rich repeats (2 copies)
    3.1e-44  148.5  11.2    1.3e-08   34.5   0.0    5.6  5  LRR_8        Leucine rich repeat
      8e-29   95.7   0.4        7.7    7.5   0.0   14.8 15  LRR_1        Leucine Rich Repeat
    1.8e-10   40.6   9.7      0.044   13.3   0.9    5.0  8  LRR_9        Leucine-rich repeat
      2e-08   34.0  20.2      0.015   14.8   1.9    4.6  5  Sialidase    Sialidase, N-terminal domain
    2.8e-05   24.0  16.2        9.2    6.3   0.0    8.9 11  ApoB100_C    Apolipoprotein B100 C terminal
    7.8e-05   23.7   3.3         25    5.9   0.0    4.9  6  bZIP_C       Basic leucine-zipper C terminal
    8.7e-05   22.7  12.6        1.3    9.1   0.1    6.3  7  NKWYS        Putative capsular polysaccharide synthesis prote
    0.00021   21.5  14.2          1    9.7   0.2    5.8  5  DUF424       Protein of unknown function (DUF424)
    0.00087   19.2  23.0       0.14   12.0   6.7    3.5  3  Beta_helix   Right handed beta helix region
  ------ inclusion threshold ------
        1.4    8.3   9.1         14    5.0   0.1    3.9  5  Tropomyosin  Tropomyosin
        2.3    8.0  20.6        6.1    6.6   0.2    5.2  5  UPF0193      Uncharacterised protein family (UPF0193)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   0.0   0.00018      0.25       5      18 ..       4      17 ..       2      22 .. 0.93
   2 !   18.2   0.0   1.3e-06    0.0017       5      24 .]      28      47 ..      25      47 .. 0.93
   3 !   13.4   0.0   4.3e-05     0.059       5      23 ..      52      70 ..      49      70 .. 0.91
   4 !   21.8   0.0   8.8e-08   0.00012       5      23 ..      76      94 ..      73      95 .. 0.91
   5 !   12.9   0.0   6.2e-05     0.086       5      18 ..     100     113 ..      97     115 .. 0.93
   6 !   16.3   0.0   5.4e-06    0.0074       5      23 ..     124     142 ..     121     142 .. 0.93
   7 !   14.8   0.0   1.5e-05     0.021       5      23 ..     148     166 ..     145     167 .. 0.91
   8 ?    0.6   0.0      0.58   7.9e+02       7      24 .]     174     190 ..     170     190 .. 0.67
   9 !    9.5   0.0   0.00081       1.1       5      18 ..     195     208 ..     192     213 .. 0.92
  10 !   15.7   0.0   8.3e-06     0.011       5      23 ..     219     237 ..     216     238 .. 0.91
  11 !   16.5   0.0   4.6e-06    0.0063       4      23 ..     242     261 ..     239     261 .. 0.92
  12 !   20.9   0.0   1.7e-07   0.00023       4      23 ..     266     285 ..     264     286 .. 0.91
  13 !   19.8   0.0   3.8e-07   0.00053       5      24 .]     291     310 ..     288     310 .. 0.91
  14 !   23.3   0.0   2.9e-08   3.9e-05       5      24 .]     315     334 ..     312     334 .. 0.94
  15 !   23.3   0.0     3e-08   4.1e-05       4      23 ..     338     357 ..     336     358 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00018
       LRR_6  5 LteLdLsgNdIgDe 18
                Lt+L +sgN+IgD+
  EFC35542.1  4 LTSLIISGNQIGDK 17
                9************6 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 1.3e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+  N IgDeG+++++
  EFC35542.1 28 LTSLDIYNNRIGDEGVKSIS 47
                9****************996 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 4.3e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                L +L++  N IgDeG++++
  EFC35542.1 52 LVSLNIYNNRIGDEGVKSI 70
                889*************987 PP

  == domain 4  score: 21.8 bits;  conditional E-value: 8.8e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+Ld+ gN IgDeG++ +
  EFC35542.1 76 LTSLDIGGNRIGDEGVKFI 94
                9***************977 PP

  == domain 5  score: 12.9 bits;  conditional E-value: 6.2e-05
       LRR_6   5 LteLdLsgNdIgDe 18 
                 Lt+L++s N+IgD+
  EFC35542.1 100 LTSLNISENQIGDK 113
                 9***********96 PP

  == domain 6  score: 16.3 bits;  conditional E-value: 5.4e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++  N IgDeG++++
  EFC35542.1 124 LTSLNIYNNRIGDEGVKSI 142
                 9***************987 PP

  == domain 7  score: 14.8 bits;  conditional E-value: 1.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++Ld+  N+I+ eGa+ +
  EFC35542.1 148 LKSLDIGRNQISVEGAKFI 166
                 9***************977 PP

  == domain 8  score: 0.6 bits;  conditional E-value: 0.58
       LRR_6   7 eLdLsgNdIgDeGaeaLa 24 
                 +L++  N I DeG+++++
  EFC35542.1 174 SLNIYNNRI-DEGVKSIS 190
                 566655656.89998885 PP

  == domain 9  score: 9.5 bits;  conditional E-value: 0.00081
       LRR_6   5 LteLdLsgNdIgDe 18 
                 Lt+L+++ N IgD+
  EFC35542.1 195 LTSLNIAENRIGDK 208
                 9************6 PP

  == domain 10  score: 15.7 bits;  conditional E-value: 8.3e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+  N IgDeGa+ +
  EFC35542.1 219 LTSLDIYNNRIGDEGAIFI 237
                 9***************977 PP

  == domain 11  score: 16.5 bits;  conditional E-value: 4.6e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+L++  N IgDeG++++
  EFC35542.1 242 QLTSLNIYNNRIGDEGVKSI 261
                 59***************987 PP

  == domain 12  score: 20.9 bits;  conditional E-value: 1.7e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+Ld+  N IgDeG++ +
  EFC35542.1 266 RLTSLDIGRNRIGDEGVKFI 285
                 59***************977 PP

  == domain 13  score: 19.8 bits;  conditional E-value: 3.8e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +Ld+s N IgDeG+++++
  EFC35542.1 291 LASLDISENRIGDEGVKSIS 310
                 679**************996 PP

  == domain 14  score: 23.3 bits;  conditional E-value: 2.9e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s N IgDeGa++++
  EFC35542.1 315 LTSLNISENRIGDEGAKSIS 334
                 9****************996 PP

  == domain 15  score: 23.3 bits;  conditional E-value: 3e-08
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  L++Ld+ gN+IgDeG++ +
  EFC35542.1 338 RLKSLDIGGNQIGDEGVKFI 357
                 59***************977 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.0   4.6e-08   6.3e-05       1      38 [.       2      40 ..       2      47 .. 0.87
   2 !   23.0   0.4   5.5e-08   7.6e-05       1      38 [.      26      64 ..      26      69 .. 0.87
   3 !   19.6   0.1   6.4e-07   0.00088       2      38 ..      51      88 ..      50      90 .. 0.86
   4 !   24.8   0.0   1.5e-08   2.1e-05       1      38 [.      74     112 ..      74     120 .. 0.89
   5 !   23.3   0.6   4.5e-08   6.2e-05       1      38 [.      98     136 ..      98     144 .. 0.87
   6 !   23.0   0.1   5.6e-08   7.7e-05       1      38 [.     122     159 ..     122     164 .. 0.85
   7 !   18.3   0.3   1.7e-06    0.0024       2      38 ..     171     207 ..     170     214 .. 0.85
   8 !   28.0   0.1   1.5e-09   2.1e-06       1      38 [.     217     255 ..     217     260 .. 0.89
   9 !   18.8   0.0   1.1e-06    0.0016       1      38 [.     265     303 ..     265     311 .. 0.88
  10 !   23.3   0.0   4.5e-08   6.2e-05       1      38 [.     313     351 ..     313     355 .. 0.87

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 4.6e-08
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38
                ++L++L +s+Nq+ d +  + + +++L++Ld+  Nn+i+d
  EFC35542.1  2 KQLTSLIISGNQIGDKEAkFISeMKQLTSLDI-YNNRIGD 40
                58************977786655*********.8889987 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 5.5e-08
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38
                ++L++Ld+ nN++ d +   ++ +++L +L++  Nn+i+d
  EFC35542.1 26 KQLTSLDIYNNRIGDEGVksISEMKQLVSLNI-YNNRIGD 64
                58************999986445*********.8889987 PP

  == domain 3  score: 19.6 bits;  conditional E-value: 6.4e-07
                S--EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4  2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38
                +L +L++ nN++ d +    +  +++L++Ld+ gN +i+d
  EFC35542.1 51 QLVSLNIYNNRIGDEGVksiI-EMKQLTSLDIGGN-RIGD 88
                7899**********9998855.5*********778.7765 PP

  == domain 4  score: 24.8 bits;  conditional E-value: 1.5e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++Ld+++N++ d +  + + +++L++L++s+N +i+d
  EFC35542.1  74 KQLTSLDIGGNRIGDEGVkFISeMKQLTSLNISEN-QIGD 112
                 58*************99996655*********999.8876 PP

  == domain 5  score: 23.3 bits;  conditional E-value: 4.5e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L++s Nq+ d +  + + +++L++L++  Nn+i+d
  EFC35542.1  98 KQLTSLNISENQIGDKEAtFISeMKQLTSLNI-YNNRIGD 136
                 58************977786655*********.8889987 PP

  == domain 6  score: 23.0 bits;  conditional E-value: 5.6e-08
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38 
                 ++L++L++ nN++ d +    +  +++Lk+Ld+ +N +i +
  EFC35542.1 122 KQLTSLNIYNNRIGDEGVksiI-EMKQLKSLDIGRN-QI-S 159
                 58*************9998855.5*********666.88.4 PP

  == domain 7  score: 18.3 bits;  conditional E-value: 1.7e-06
                 S--EEE--SS---.E-S-HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqlt.diplleklpnLkeLdLsgNnlitd 38 
                 +L +L++ nN++   + +++ +++L++L++ +N +i+d
  EFC35542.1 171 QLVSLNIYNNRIDeGVKSISEMKQLTSLNIAEN-RIGD 207
                 7899*******9977666667*********888.7765 PP

  == domain 8  score: 28.0 bits;  conditional E-value: 1.5e-09
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+ nN++ d +   ++k+++L++L++  Nn+i+d
  EFC35542.1 217 KQLTSLDIYNNRIGDEGAifISKMKQLTSLNI-YNNRIGD 255
                 58*************99995557*********.8889987 PP

  == domain 9  score: 18.8 bits;  conditional E-value: 1.1e-06
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++Ld++ N++ d +  + + +++L +Ld+s+N +i+d
  EFC35542.1 265 KRLTSLDIGRNRIGDEGVkFISeMKQLASLDISEN-RIGD 303
                 68*************99996655*********999.7765 PP

  == domain 10  score: 23.3 bits;  conditional E-value: 4.5e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++s N++ d +   ++ ++ Lk+Ld+ gN +i+d
  EFC35542.1 313 KQLTSLNISENRIGDEGAksISEMKRLKSLDIGGN-QIGD 351
                 58*************99986445*********777.9876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.1     1e-09   1.4e-06       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   33.1   0.1   2.6e-11   3.6e-08       2      61 .]      75     134 ..      74     134 .. 0.98
   3 !   28.7   0.2   5.9e-10   8.2e-07       2      61 .]     147     205 ..     146     205 .. 0.96
   4 !   28.1   0.1   9.4e-10   1.3e-06       2      61 .]     218     277 ..     217     277 .. 0.98
   5 !   34.5   0.0   9.3e-12   1.3e-08       2      61 .]     290     349 ..     289     349 .. 0.98

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 1e-09
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsL++s N++ + + ++ + +++L++Ld+ nN++     +++s +++L sL++ +Nr+
  EFC35542.1  3 QLTSLIISGNQIGDKEAKFISEMKQLTSLDIYNNRIGDEGVKSISEMKQLVSLNIYNNRI 62
                7*********************************************************97 PP

  == domain 2  score: 33.1 bits;  conditional E-value: 2.6e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+  Nr+ + + ++ + +++L++L++s+N++   ++  +s +++L+sL++ +Nr+
  EFC35542.1  75 QLTSLDIGGNRIGDEGVKFISEMKQLTSLNISENQIGDKEATFISEMKQLTSLNIYNNRI 134
                 7*********************************************************97 PP

  == domain 3  score: 28.7 bits;  conditional E-value: 5.9e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+sLd+ +N++++ + ++ + +++L +L++ nN+++    +++s +++L+sL++  Nr+
  EFC35542.1 147 QLKSLDIGRNQISVEGAKFISEMKQLVSLNIYNNRIDEG-VKSISEMKQLTSLNIAENRI 205
                 7*************************************6.48****************97 PP

  == domain 4  score: 28.1 bits;  conditional E-value: 9.4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+ nNr+ + +  + +++++L++L++ nN++     +++  +++L+sLd+ +Nr+
  EFC35542.1 218 QLTSLDIYNNRIGDEGAIFISKMKQLTSLNIYNNRIGDEGVKSIIEMKRLTSLDIGRNRI 277
                 7*********************************************************97 PP

  == domain 5  score: 34.5 bits;  conditional E-value: 9.3e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L sLd+s Nr+ + + ++ + +++L++L++s+N++    ++++s +++L+sLd+ gN++
  EFC35542.1 290 QLASLDISENRIGDEGVKSISEMKQLTSLNISENRIGDEGAKSISEMKRLKSLDIGGNQI 349
                 799*******************************************************98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0     0.099   1.4e+02       1      20 [.       3      22 ..       3      25 .. 0.82
   2 !    6.9   0.0    0.0085        12       1      21 [.      27      47 ..      27      49 .. 0.87
   3 ?    3.7   0.0       0.1   1.4e+02       2      19 ..      52      69 ..      51      72 .. 0.81
   4 ?    5.8   0.0     0.019        27       1      17 [.      75      91 ..      75      97 .. 0.79
   5 ?    4.5   0.0     0.053        74       1      17 [.      99     115 ..      99     121 .. 0.80
   6 ?    5.5   0.0     0.025        35       1      19 [.     123     141 ..     123     144 .. 0.83
   7 ?    6.0   0.0     0.017        24       1      16 [.     147     162 ..     147     169 .. 0.78
   8 ?    3.2   0.0      0.14     2e+02       2      20 ..     172     189 ..     171     192 .. 0.76
   9 ?    2.5   0.0      0.24   3.3e+02       1      20 [.     194     213 ..     194     216 .. 0.81
  10 ?    4.9   0.0     0.039        54       1      15 [.     218     232 ..     218     240 .. 0.80
  11 ?    5.5   0.0     0.025        35       1      19 [.     242     260 ..     242     263 .. 0.83
  12 ?    5.4   0.0     0.027        37       1      17 [.     266     282 ..     266     288 .. 0.79
  13 ?    3.1   0.0      0.16   2.1e+02       2      21 ..     291     310 ..     290     312 .. 0.84
  14 ?    6.2   0.0     0.015        21       1      21 [.     314     334 ..     314     336 .. 0.88
  15 !    7.5   0.0    0.0056       7.7       1      17 [.     338     354 ..     338     360 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.099
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++L +s+n+++++++  +
  EFC35542.1  3 QLTSLIISGNQIGDKEAKFI 22
                599********998887665 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0085
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++Ld+ nn++++ +  s++
  EFC35542.1 27 QLTSLDIYNNRIGDEGVKSIS 47
                599*********999988876 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.1
       LRR_1  2 LrhLdLsnnpllglppns 19
                L +L++ nn++++ +  s
  EFC35542.1 52 LVSLNIYNNRIGDEGVKS 69
                889*******98777665 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.019
       LRR_1  1 nLrhLdLsnnpllglpp 17
                +L++Ld+++n++++ + 
  EFC35542.1 75 QLTSLDIGGNRIGDEGV 91
                599********977655 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.053
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++s n+++++++
  EFC35542.1  99 QLTSLNISENQIGDKEA 115
                 599********987765 PP

  == domain 6  score: 5.5 bits;  conditional E-value: 0.025
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L++ nn++++ +  s
  EFC35542.1 123 QLTSLNIYNNRIGDEGVKS 141
                 599********98777665 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.017
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++Ld+++n+++  +
  EFC35542.1 147 QLKSLDIGRNQISVEG 162
                 59********996555 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.14
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L +L++ nn++ + +  s+
  EFC35542.1 172 LVSLNIYNNRI-DEGVKSI 189
                 889******99.5666655 PP

  == domain 9  score: 2.5 bits;  conditional E-value: 0.24
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++  n+++++++  +
  EFC35542.1 194 QLTSLNIAENRIGDKEAKFI 213
                 599********988877655 PP

  == domain 10  score: 4.9 bits;  conditional E-value: 0.039
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++Ld+ nn++++ 
  EFC35542.1 218 QLTSLDIYNNRIGDE 232
                 599*******99665 PP

  == domain 11  score: 5.5 bits;  conditional E-value: 0.025
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L++ nn++++ +  s
  EFC35542.1 242 QLTSLNIYNNRIGDEGVKS 260
                 599********98777665 PP

  == domain 12  score: 5.4 bits;  conditional E-value: 0.027
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++Ld+++n++++ + 
  EFC35542.1 266 RLTSLDIGRNRIGDEGV 282
                 69*********977655 PP

  == domain 13  score: 3.1 bits;  conditional E-value: 0.16
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L +Ld+s n++++ +  s++
  EFC35542.1 291 LASLDISENRIGDEGVKSIS 310
                 669********999888876 PP

  == domain 14  score: 6.2 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++s n++++ ++ s++
  EFC35542.1 314 QLTSLNISENRIGDEGAKSIS 334
                 599*********999999887 PP

  == domain 15  score: 7.5 bits;  conditional E-value: 0.0056
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++Ld+++n++++ + 
  EFC35542.1 338 RLKSLDIGGNQIGDEGV 354
                 69*********977655 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.1   0.00063      0.87      49     123 ..       9      84 ..       1      90 [. 0.66
   2 !   11.4   0.4   0.00013      0.17      43     130 ..      27     115 ..      20     129 .. 0.73
   3 !    9.5   0.5   0.00046      0.64      42     123 ..      98     180 ..      93     186 .. 0.57
   4 !   11.3   1.3   0.00013      0.18      57     145 ..     139     222 ..     121     224 .. 0.76
   5 !   13.3   0.9   3.2e-05     0.044      43     142 ..     147     243 ..     143     250 .. 0.57
   6 !   12.2   0.2   6.8e-05     0.094      43     124 ..     194     276 ..     191     281 .. 0.74
   7 !   11.2   0.2   0.00014      0.19      57     127 ..     258     327 ..     240     345 .. 0.79
   8 !    8.2   0.0    0.0011       1.6      42     115 ..     289     363 ..     283     367 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00063
       LRR_9  49 lsdndirkldg..fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                 +s n+i + +   +  +k+l +l + nnri   + +    + +l +l + nn++ + + ++ ++++k+l++l +  n
  EFC35542.1   9 ISGNQIGDKEAkfISEMKQLTSLDIYNNRIGDEGVKSISEMKQLVSLNIYNNRIGDEG-VKSIIEMKQLTSLDIGGN 84 
                 5556664333211456888889999999987666555556677777778888888765.588888888888877655 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00013
       LRR_9  43 qfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkke 130
                 q+ ++d+ +n i +  + ++  +k+l +l + nnri   + +    + +l++l + +n++ + + ++ + ++k+l++l + +n + +k+ 
  EFC35542.1  27 QLTSLDIYNNRIGDegVKSISEMKQLVSLNIYNNRIGDEGVKSIIEMKQLTSLDIGGNRIGDEG-VKFISEMKQLTSLNISENQIGDKEA 115
                 6667777777774323677888999999999999998654444445678999999999999866.5899999999999999999988764 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00046
       LRR_9  42 dqfdtidlsdndirkldg..fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                  q+ ++++s+n+i + +   +  +k+l +l + nnri   + +    + +l++l +  n++   +  + + ++k+l +l + +n
  EFC35542.1  98 KQLTSLNISENQIGDKEAtfISEMKQLTSLNIYNNRIGDEGVKSIIEMKQLKSLDIGRNQISVEGA-KFISEMKQLVSLNIYNN 180
                 466666777777754443214557777777777777764333333334566666666666654433.56666666666666655 PP

  == domain 4  score: 11.3 bits;  conditional E-value: 0.00013
       LRR_9  57 ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrll 145
                 + ++  +k+lk+l +  n+i   + ++   + +l +l + nn+++e ++   + ++k+l++l + +n + +k+      i  +kql+ l
  EFC35542.1 139 VKSIIEMKQLKSLDIGRNQISVEGAKFISEMKQLVSLNIYNNRIDEGVK--SISEMKQLTSLNIAENRIGDKEA---KFISEMKQLTSL 222
                 5556678999999999999999999999999999999999999998655..89999999999999999988874...445566666555 PP

  == domain 5  score: 13.3 bits;  conditional E-value: 3.2e-05
       LRR_9  43 qfdtidlsdndirkldgfPl...lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyk 138
                 q+ ++d+  n+i  ++g  +   +k+l +l + nnri    + ++e + +l++l +++n++ +    + + ++k+l++l + +n + ++       i k
  EFC35542.1 147 QLKSLDIGRNQIS-VEGAKFiseMKQLVSLNIYNNRIDEGVKSISE-MKQLTSLNIAENRIGDKEA-KFISEMKQLTSLDIYNNRIGDEG---AIFISK 239
                 5556666666663.45544411144444555666666655555554.4677777777777777544.77777777777777777765543...344555 PP

       LRR_9 139 lkql 142
                 +kql
  EFC35542.1 240 MKQL 243
                 5555 PP

  == domain 6  score: 12.2 bits;  conditional E-value: 6.8e-05
       LRR_9  43 qfdtidlsdndirkldg..fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                 q+ ++++++n i + +   +  +k+l +l + nnri   +  +   + +l++l + nn++ + + ++ ++++k+l++l + +n 
  EFC35542.1 194 QLTSLNIAENRIGDKEAkfISEMKQLTSLDIYNNRIGDEGAIFISKMKQLTSLNIYNNRIGDEG-VKSIIEMKRLTSLDIGRNR 276
                 6666777777775443321567888889999999998888888888889999999999998865.5888899999888887776 PP

  == domain 7  score: 11.2 bits;  conditional E-value: 0.00014
       LRR_9  57 ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 + ++  +krl +l +  nri   + ++   + +l +l +++n++ + + ++ + ++k+l++l + +n + +
  EFC35542.1 258 VKSIIEMKRLTSLDIGRNRIGDEGVKFISEMKQLASLDISENRIGDEG-VKSISEMKQLTSLNISENRIGD 327
                 55666799************9999999999999***********9976.599**********999998765 PP

  == domain 8  score: 8.2 bits;  conditional E-value: 0.0011
       LRR_9  42 dqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkl 115
                  q+ ++d+s+n i +  + ++  +k+l +l +++nri   + +    + +l++l + +n++ + + ++ + ++k+l
  EFC35542.1 289 KQLASLDISENRIGDegVKSISEMKQLTSLNISENRIGDEGAKSISEMKRLKSLDIGGNQIGDEG-VKFISEMKQL 363
                 57777888888885433777888888888888888887777666666777777777777776643.3445555554 PP

>> Sialidase  Sialidase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.6   1.6e-05     0.022     124     184 ..      10      70 ..       2      75 .. 0.78
   2 !   13.6   0.6   2.5e-05     0.034     129     184 ..      85     142 ..      71     147 .. 0.80
   3 ?   -0.3   0.1      0.47   6.5e+02     141     185 ..     145     190 ..     142     196 .. 0.57
   4 !   14.8   1.9   1.1e-05     0.015     128     184 ..     203     261 ..     171     266 .. 0.78
   5 ?    1.7   0.1      0.11   1.5e+02     131     185 ..     278     334 ..     271     338 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.6e-05
   Sialidase 124 NGvieevsetsdkFikniedvdkatiGatnRegkeeyla...kgsidelsvyNkalsdeevskk 184
                  G  +++ ++  kFi++++++++  i   nR g+e  ++     ++  l++yN+ ++de v+++
  EFC35542.1  10 SG--NQIGDKEAKFISEMKQLTSLDIY-NNRIGDEGVKSiseMKQLVSLNIYNNRIGDEGVKSI 70 
                 55..6788999***************6.588887666551115567789***********9987 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 2.5e-05
   Sialidase 129 evsetsdkFikniedvdkatiGatnReg.keeylak.gsidelsvyNkalsdeevskk 184
                 ++ +   kFi++++++++  i   +  + +  + ++  ++  l++yN+ ++de v+++
  EFC35542.1  85 RIGDEGVKFISEMKQLTSLNISENQIGDkEATFISEmKQLTSLNIYNNRIGDEGVKSI 142
                 66777889*************98766554445655526899*************9987 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.47
   Sialidase 141 iedvdkatiGatn..RegkeeylakgsidelsvyNkalsdeevskks 185
                 ++++ +  iG+ +   eg +      ++  l++yN+ + de v+++s
  EFC35542.1 145 MKQLKSLDIGRNQisVEGAKFISEMKQLVSLNIYNNRI-DEGVKSIS 190
                 55555556665431123333344445777888888877.55666655 PP

  == domain 4  score: 14.8 bits;  conditional E-value: 1.1e-05
   Sialidase 128 eevsetsdkFikniedvdkatiGatnRegke..eylakg.sidelsvyNkalsdeevskk 184
                 +++ ++  kFi++++++++  i   nR g+e   + +k  ++  l++yN+ ++de v+++
  EFC35542.1 203 NRIGDKEAKFISEMKQLTSLDIY-NNRIGDEgaIFISKMkQLTSLNIYNNRIGDEGVKSI 261
                 6788999***************6.58998552267777538999************9987 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.11
   Sialidase 131 setsdkFikniedvdkatiGatnRegkeeylakg...sidelsvyNkalsdeevskks 185
                  +   kFi++++++ +  i   nR g+e  ++     ++  l++  + ++de  +++s
  EFC35542.1 278 GDEGVKFISEMKQLASLDISE-NRIGDEGVKSISemkQLTSLNISENRIGDEGAKSIS 334
                 5666799*****999999965.788876665544001555666777778888777766 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.1     0.018        25      11      33 ..      12      34 ..       9      38 .. 0.87
   2 ?    0.3   0.0      0.51   7.1e+02      19      33 ..      44      58 ..      34      61 .. 0.82
   3 ?    2.0   0.0      0.15   2.1e+02      19      32 ..      92     105 ..      84     108 .. 0.83
   4 ?    4.2   0.1     0.031        43      11      33 ..     108     130 ..     103     133 .. 0.87
   5 !    6.3   0.0    0.0066       9.2      11      34 ..     156     179 ..     149     182 .. 0.86
   6 ?    4.2   0.1      0.03        42      10      33 ..     202     225 ..     194     229 .. 0.84
   7 ?   -3.1   0.0       5.8   7.9e+03      20      32 ..     236     248 ..     234     250 .. 0.82
   8 ?    2.6   0.0     0.096   1.3e+02      19      33 ..     283     297 ..     274     301 .. 0.82
   9 ?   -2.6   0.0       4.1   5.7e+03      19      33 ..     307     321 ..     303     325 .. 0.83
  10 ?   -2.1   0.0       2.9     4e+03      14      31 ..     326     343 ..     314     346 .. 0.75
  11 ?    1.3   0.0      0.24   3.3e+02      12      30 ..     348     366 ..     339     367 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.018
   ApoB100_C 11 dqlsdyyEkliaeskrLiDLsIe 33
                +q+ d   k+i+e k+L  L I 
  EFC35542.1 12 NQIGDKEAKFISEMKQLTSLDIY 34
                68999999*********999885 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.51
   ApoB100_C 19 kliaeskrLiDLsIe 33
                k i+e k+L+ L I 
  EFC35542.1 44 KSISEMKQLVSLNIY 58
                779*********995 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.15
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  L I
  EFC35542.1  92 KFISEMKQLTSLNI 105
                 9********99988 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.031
   ApoB100_C  11 dqlsdyyEkliaeskrLiDLsIe 33 
                 +q+ d   ++i+e k+L  L I 
  EFC35542.1 108 NQIGDKEATFISEMKQLTSLNIY 130
                 79999999*********999985 PP

  == domain 5  score: 6.3 bits;  conditional E-value: 0.0066
   ApoB100_C  11 dqlsdyyEkliaeskrLiDLsIek 34 
                 +q+s    k+i+e k+L+ L I +
  EFC35542.1 156 NQISVEGAKFISEMKQLVSLNIYN 179
                 67777778************9965 PP

  == domain 6  score: 4.2 bits;  conditional E-value: 0.03
   ApoB100_C  10 sdqlsdyyEkliaeskrLiDLsIe 33 
                  +++ d   k+i+e k+L  L I 
  EFC35542.1 202 ENRIGDKEAKFISEMKQLTSLDIY 225
                 567888899*********999885 PP

  == domain 7  score: -3.1 bits;  conditional E-value: 5.8
   ApoB100_C  20 liaeskrLiDLsI 32 
                 +i++ k+L  L I
  EFC35542.1 236 FISKMKQLTSLNI 248
                 8999999988887 PP

  == domain 8  score: 2.6 bits;  conditional E-value: 0.096
   ApoB100_C  19 kliaeskrLiDLsIe 33 
                 k+i+e k+L  L I 
  EFC35542.1 283 KFISEMKQLASLDIS 297
                 9********999885 PP

  == domain 9  score: -2.6 bits;  conditional E-value: 4.1
   ApoB100_C  19 kliaeskrLiDLsIe 33 
                 k i+e k+L  L I 
  EFC35542.1 307 KSISEMKQLTSLNIS 321
                 569999999999885 PP

  == domain 10  score: -2.1 bits;  conditional E-value: 2.9
   ApoB100_C  14 sdyyEkliaeskrLiDLs 31 
                  d   k i+e krL  L 
  EFC35542.1 326 GDEGAKSISEMKRLKSLD 343
                 555568899999996665 PP

  == domain 11  score: 1.3 bits;  conditional E-value: 0.24
   ApoB100_C  12 qlsdyyEkliaeskrLiDL 30 
                 q+ d   k+i+e k+L  L
  EFC35542.1 348 QIGDEGVKFISEMKQLASL 366
                 6777777********9866 PP

>> bZIP_C  Basic leucine-zipper C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0     0.022        31      52     118 ..      15      86 ..      10      91 .. 0.79
   2 ?    2.2   0.1      0.25   3.4e+02      71     119 ..     106     135 ..      84     163 .. 0.47
   3 ?    4.6   0.0     0.045        62      69     120 ..     180     231 ..     160     234 .. 0.62
   4 ?    5.9   0.0     0.018        25      53     119 ..     207     278 ..     201     283 .. 0.76
   5 ?    4.6   0.0     0.045        62      64     119 ..     242     302 ..     231     305 .. 0.72
   6 ?    4.1   0.1     0.063        87      64     113 ..     290     344 ..     279     354 .. 0.66

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.022
      bZIP_C  52 qddpkhyfnltstaddlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkri 118
                  d+  ++ + ++  ++l++ nn ++d ++ ++ e ++l++ ++ ++ +g      + ++++ +sL+   +ri
  EFC35542.1  15 GDKEAKFISEMKQLTSLDIYNNRIGDEGVKSISEMKQLVSLNIYNNRIGdegvkSIIEMKQLTSLDIGGNRI 86 
                 566777778888888899999999999999999999999999988888888666666778889998777777 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.25
      bZIP_C  71 lnnglpdissvelqekadlanaavaagkmgrtasLqrvasLehlqkrir 119
                 ++n ++d   +                    ++++++ +sL+   +ri 
  EFC35542.1 106 SENQIGDKEAT-------------------FISEMKQLTSLNIYNNRIG 135
                 33333332222...................3444444444444444443 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.045
      bZIP_C  69 qvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkrirg 120
                 ++ ++g++ is +     ++l + ++a++ +g      ++++++ +sL+   +ri +
  EFC35542.1 180 NRIDEGVKSISEM-----KQLTSLNIAENRIGdkeakFISEMKQLTSLDIYNNRIGD 231
                 3344444444444.....444444445555554444488999*******99999964 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.018
      bZIP_C  53 ddpkhyfnltstaddlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkrir 119
                 d+  ++ + ++  ++l++ nn ++d + + + + ++l + ++ ++ +g      + +++r +sL+  ++ri 
  EFC35542.1 207 DKEAKFISEMKQLTSLDIYNNRIGDEGAIFISKMKQLTSLNIYNNRIGdegvkSIIEMKRLTSLDIGRNRIG 278
                 5566677777778888999999999988866666667777777777777755578888*******9999996 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.045
      bZIP_C  64 taddlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkrir 119
                   ++l++ nn ++d ++ ++ e + l +  +  + +g      ++++++ asL+   +ri 
  EFC35542.1 242 QLTSLNIYNNRIGDEGVKSIIEMKRLTSLDIGRNRIGdegvkFISEMKQLASLDISENRIG 302
                 4456677788888888877777777777777777777776667788899999998888885 PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.063
      bZIP_C  64 taddlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLeh 113
                   ++l++++n ++d ++ ++ e ++l + +++++ +g      +++++r  sL+ 
  EFC35542.1 290 QLASLDISENRIGDEGVKSISEMKQLTSLNISENRIGdegakSISEMKRLKSLDI 344
                 4455666677777777777777777777777777777776666777777777775 PP

>> NKWYS  Putative capsular polysaccharide synthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.1     0.013        18      37      63 ..      21      46 ..      16      70 .. 0.77
   2 ?    1.0   0.0      0.32   4.4e+02      40      67 ..      48      75 ..      46      85 .. 0.83
   3 ?    4.9   0.3      0.02        27      40      91 ..      96     148 ..      88     161 .. 0.53
   4 ?    4.6   0.3     0.023        32      37      87 ..     117     168 ..     112     181 .. 0.76
   5 ?    1.8   0.1      0.17   2.4e+02      37      56 ..     165     184 ..     156     211 .. 0.82
   6 !    9.1   0.1   0.00097       1.3      37      76 ..     212     251 ..     202     276 .. 0.79
   7 ?    2.4   0.1      0.12   1.6e+02      37      90 ..     284     338 ..     282     348 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.013
       NKWYS 37 FDnElkknlgiDvfnkdfdkdegfvif 63
                F  E+k+++++D++n+ + ++  ++ +
  EFC35542.1 21 FISEMKQLTSLDIYNNRIGDEG-VKSI 46
                678**************98654.4433 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.32
       NKWYS 40 ElkknlgiDvfnkdfdkdegfvifnnkk 67
                E+k++++++++n+ + ++    i++ k+
  EFC35542.1 48 EMKQLVSLNIYNNRIGDEGVKSIIEMKQ 75
                99*************9988777777665 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.02
       NKWYS  40 ElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikdfLni 91 
                 E+k+++++++ ++++ ++e ++i + k+   l i  +++ +   k+i ++  +
  EFC35542.1  96 EMKQLTSLNISENQIGDKEATFISEMKQLTSLNIYNNRIGDEgVKSIIEMKQL 148
                 56666666666666666665555555554444444333322224444444444 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.023
       NKWYS  37 FDnElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikd 87 
                 F  E+k++++++++n+ + ++    i++ k+ + l i  ++++    k i +
  EFC35542.1 117 FISEMKQLTSLNIYNNRIGDEGVKSIIEMKQLKSLDIGRNQISVEgAKFISE 168
                 678****************999999999999887777666655444555555 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.17
       NKWYS  37 FDnElkknlgiDvfnkdfdk 56 
                 F  E+k++++++++n+ +d+
  EFC35542.1 165 FISEMKQLVSLNIYNNRIDE 184
                 668999*********99986 PP

  == domain 6  score: 9.1 bits;  conditional E-value: 0.00097
       NKWYS  37 FDnElkknlgiDvfnkdfdkdegfvifnnkkfslllikse 76 
                 F  E+k+++++D++n+ + ++  ++i + k+   l i  +
  EFC35542.1 212 FISEMKQLTSLDIYNNRIGDEGAIFISKMKQLTSLNIYNN 251
                 778****************999999999888776665554 PP

  == domain 7  score: 2.4 bits;  conditional E-value: 0.12
       NKWYS  37 FDnElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikdfLn 90 
                 F  E+k++ ++D+ ++ + ++    i + k+   l i  +++ +   k+i ++  
  EFC35542.1 284 FISEMKQLASLDISENRIGDEGVKSISEMKQLTSLNISENRIGDEgAKSISEMKR 338
                 5579999999999999999887777777777776666666554444666666655 PP

>> DUF424  Protein of unknown function (DUF424)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.1      0.19   2.6e+02      28      63 ..      30      62 ..       6      72 .. 0.70
   2 !    8.2   0.2    0.0022         3      27      64 ..     101     135 ..      88     145 .. 0.81
   3 !    9.7   0.2   0.00073         1      31      64 ..     173     206 ..     159     215 .. 0.83
   4 ?    1.5   0.1      0.27   3.7e+02      32      64 ..     225     254 ..     208     266 .. 0.70
   5 ?    5.4   0.1     0.016        22      27      63 ..     292     325 ..     279     355 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.19
                EEE--HHHH--EEE-HHHHHHHHHHHEEEEEESHHH CS
      DUF424 28 llnvsegfyggelaseeeaikeLekatiaNivgeea 63
                +l + +  +g e +   ++i+e++++   Ni  +++
  EFC35542.1 30 SLDIYNNRIGDEGV---KSISEMKQLVSLNIYNNRI 62
                44444555555555...8888888888888877765 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0022
                 EEEE--HHHH--EEE-HHHHHHHHHHHEEEEEESHHHH CS
      DUF424  27 lllnvsegfyggelaseeeaikeLekatiaNivgeeav 64 
                 ++ln+se  +g + a   ++i+e++++t  Ni  +++ 
  EFC35542.1 101 TSLNISENQIGDKEA---TFISEMKQLTSLNIYNNRIG 135
                 899********9999...**************988765 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00073
                 --HHHH--EEE-HHHHHHHHHHHEEEEEESHHHH CS
      DUF424  31 vsegfyggelaseeeaikeLekatiaNivgeeav 64 
                 vs  +y +++++  ++i+e++++t  Ni ++++ 
  EFC35542.1 173 VSLNIYNNRIDEGVKSISEMKQLTSLNIAENRIG 206
                 78889***********************999875 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.27
                 -HHHH--EEE-HHHHHHHHHHHEEEEEESHHHH CS
      DUF424  32 segfyggelaseeeaikeLekatiaNivgeeav 64 
                  +  +g e a    +i++++++t  Ni  +++ 
  EFC35542.1 225 YNNRIGDEGA---IFISKMKQLTSLNIYNNRIG 254
                 3333444333...78999999999999887765 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.016
                 EEEE--HHHH--EEE-HHHHHHHHHHHEEEEEESHHH CS
      DUF424  27 lllnvsegfyggelaseeeaikeLekatiaNivgeea 63 
                 ++l +se  +g e +   ++i+e++++t  Ni ++++
  EFC35542.1 292 ASLDISENRIGDEGV---KSISEMKQLTSLNISENRI 325
                 678888888888888...9999999999999987764 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   8.0     0.002       2.7      36     134 ..      33     134 ..       2     142 .. 0.55
   2 !   12.0   6.7   9.9e-05      0.14      21     157 ..      86     228 ..      71     229 .. 0.79
   3 !   10.7   2.6   0.00025      0.34      59     143 ..     224     334 ..     213     353 .. 0.49

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.002
                 EES-EEES-SS-SEEE-TT.-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT---EEES CS
  Beta_helix  36 ienneiannsgsGiyilgs.snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdsssnvtvtn 131
                 i nn+i + +   i+  ++    +i+nn+i d +  + i +++     i +n+i d g   i+ + + +++ i++N+i + ++  i+ + + +++++ n
  EFC35542.1  33 IYNNRIGDEGVKSISEMKQlVSLNIYNNRIGDEGvKSIIEMKQLTSLDIGGNRIGDEGVKFISEMkQLTSLNISENQIGDKEATFISEMKQLTSLNIYN 131
                 334444443334444333355666666666666656666666666666666666666554443332456666777777666655555555556666666 PP

                 -EE CS
  Beta_helix 132 Nti 134
                 N+i
  EFC35542.1 132 NRI 134
                 666 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 9.9e-05
                 -SS-SEEE-SSS-.....EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEES CS
  Beta_helix  21 sggyGiylrgssn....vvienneiannsgsGiyilgs.snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntienNiidn 112
                 +g+ G+++ + ++      i++n i +   + i+  ++ +  +i+nn+i d +  + i +++ +   i +n i+  g   i+ + +  ++ i nN+id+
  EFC35542.1  86 IGDEGVKFISEMKqltsLNISENQIGDKEATFISEMKQlTSLNIYNNRIGDEGvKSIIEMKQLKSLDIGRNQISVEGAKFISEMkQLVSLNIYNNRIDE 184
                 37788888888887777666668888866777766666799999999999999889999999999999999999998877754435777999*****99 PP

                 TT--SEE---TT---EEES-EEES-SSEEEE-TT-SS--EEES-E CS
  Beta_helix 113 nagsGividdsssnvtvtnNtitnnkgaGiavvgsssnvtvrnNt 157
                      i+ + + +++++  N+i +   + i  + + +++ ++nN 
  EFC35542.1 185 GV-KSISEMKQLTSLNIAENRIGDKEAKFISEMKQLTSLDIYNNR 228
                 99.8888888878999*****999998888888888888888886 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00025
                 EES-EEE---.SEEE-TT--S--EEES-EEES-.....................SS-SEE-TT....-S--EEES-EEESTT--SEE---TT---EEES CS
  Beta_helix  59 isnntisdnn.gggialfgasnnlienneitdn.....................ggsGiylny....ssnntienNiidnnagsGividdsssnvtvtn 131
                 i+nn+i d +  +  ++++     i+nn+i d                      g+ G+ + +      +++i++N+i + +   i+ + + ++++++ 
  EFC35542.1 224 IYNNRIGDEGaIFISKMKQLTSLNIYNNRIGDEgvksiiemkrltsldigrnriGDEGVKFISemkqLASLDISENRIGDEGVKSISEMKQLTSLNISE 322
                 455555554422222233444444555555555322222222222222222222122333332222244477777777777777777777777777777 PP

                 -EEES-SSEEEE CS
  Beta_helix 132 NtitnnkgaGia 143
                 N+i + + ++i 
  EFC35542.1 323 NRIGDEGAKSIS 334
                 777766666655 PP

>> Tropomyosin  Tropomyosin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.039        54     155     183 ..       2      30 ..       1      52 [. 0.90
   2 ?    5.0   0.1      0.01        14     155     183 ..      98     126 ..      89     136 .. 0.88
   3 ?   -0.3   0.0      0.42   5.8e+02     155     202 ..     146     192 ..     140     197 .. 0.84
   4 ?    3.7   0.2     0.025        35     155     183 ..     193     221 ..     180     229 .. 0.87
   5 ?   -3.0   0.1       2.7   3.8e+03     155     167 ..     313     325 ..     288     341 .. 0.49

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.039
  Tropomyosin 155 nnlksLevseekaseredeyeeeirtLee 183
                  ++l sL +s ++  ++e ++  e+++L++
   EFC35542.1   2 KQLTSLIISGNQIGDKEAKFISEMKQLTS 30 
                  5789**********************985 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.01
  Tropomyosin 155 nnlksLevseekaseredeyeeeirtLee 183
                  ++l sL +se++  ++e ++  e+++L++
   EFC35542.1  98 KQLTSLNISENQIGDKEATFISEMKQLTS 126
                  6899**********************985 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.42
  Tropomyosin 155 nnlksLevseekaseredeyeeeirtLeekLkeaeeRaeeAErsvqkL 202
                  ++lksL +  ++ s    ++  e+++L   L  +++R +e  +s++++
   EFC35542.1 146 KQLKSLDIGRNQISVEGAKFISEMKQLV-SLNIYNNRIDEGVKSISEM 192
                  789**********************996.4888888888887777766 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.025
  Tropomyosin 155 nnlksLevseekaseredeyeeeirtLee 183
                  ++l sL ++e++  ++e ++  e+++L++
   EFC35542.1 193 KQLTSLNIAENRIGDKEAKFISEMKQLTS 221
                  6799**********************985 PP

  == domain 5  score: -3.0 bits;  conditional E-value: 2.7
  Tropomyosin 155 nnlksLevseeka 167
                  ++l sL +se++ 
   EFC35542.1 313 KQLTSLNISENRI 325
                  2344444444444 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.2    0.0044       6.1     172     207 ..      19      54 ..      11      62 .. 0.87
   2 ?    4.7   0.6     0.016        23     166     207 ..     108     150 ..      94     160 .. 0.86
   3 ?    2.5   0.2      0.08   1.1e+02     170     213 ..     161     203 ..     155     207 .. 0.84
   4 ?    4.4   0.2      0.02        28     172     207 ..     210     245 ..     201     252 .. 0.87
   5 ?    1.7   0.2      0.14   1.9e+02     170     213 ..     280     323 ..     275     326 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0044
     UPF0193 172 keFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 ++F++eM++L   + Y++ I +e  + + e+++l +
  EFC35542.1  19 AKFISEMKQLTSLDIYNNRIGDEGVKSISEMKQLVS 54 
                 58******************************9976 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.016
     UPF0193 166 keIeeRk.eFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 ++I +++  F++eM++L   + Y++ I +e  + + e+++l++
  EFC35542.1 108 NQIGDKEaTFISEMKQLTSLNIYNNRIGDEGVKSIIEMKQLKS 150
                 566666427******************************9976 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.08
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdkkrseel 213
                 e ++F++eM++L   + Y++ I + + + + e+++l + + +e+
  EFC35542.1 161 EGAKFISEMKQLVSLNIYNNRIDEGV-KSISEMKQLTSLNIAEN 203
                 5579******************8776.78999999988776665 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.02
     UPF0193 172 keFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 ++F++eM++L   + Y++ I +e +  + ++++l +
  EFC35542.1 210 AKFISEMKQLTSLDIYNNRIGDEGAIFISKMKQLTS 245
                 58***********************99999999876 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.14
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdkkrseel 213
                 e ++F++eM++L   +  ++ I +e  + + e+++l + + +e+
  EFC35542.1 280 EGVKFISEMKQLASLDISENRIGDEGVKSISEMKQLTSLNISEN 323
                 5579*******************************998776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (368 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       340  (0.0189637); expected 358.6 (0.02)
Passed bias filter:                      151  (0.00842211); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.77u 0.36s 00:00:01.12 Elapsed: 00:00:00.55
# Mc/sec: 2018.62
//
Query:       EFC35543.1  [L=320]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.7e-30  105.9   0.2      2e-26   92.7   0.3    2.1  2  adh_short     short chain dehydrogenase
    4.9e-19   68.8   0.0    2.2e-18   66.7   0.0    1.8  2  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    6.6e-05   22.9   0.1    9.1e-05   22.4   0.1    1.3  1  KR            KR domain
     0.0018   18.0   0.0     0.0032   17.2   0.0    1.3  1  Flavodoxin_4  Flavodoxin


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.7   0.3   4.4e-30     2e-26       1     150 [.      47     197 ..      47     198 .. 0.92
   2 !   11.2   0.0     4e-05      0.18     144     188 ..     214     261 ..     203     264 .. 0.90

  Alignments for each domain:
  == domain 1  score: 92.7 bits;  conditional E-value: 4.4e-30
                 SEEEEESTTS.HHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT...TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGG CS
   adh_short   1 kvvlvtGass.GIGraiakelakeGakvvvvdrseekleevakelkee...gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfse 95 
                 k+v+vtGas+ GIG +++k l + Ga+vv++ r++ +  ++++ +++e   ++k++++ +D++d ++v+++ e  ++k+ +ld+L+nNAGi    ++  
  EFC35543.1  47 KIVIVTGASAgGIGFETSKVLHRLGATVVLAVRNQLAGDKAKELIEKEngnSDKLIVMLIDLADLASVKKFTELFMSKFNQLDILINNAGI---MSIYG 142
                 79******8537******************999998888888888877777999*************************************...57788 PP

                 CSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-TTBHHHH CS
   adh_short  96 lseeewervievNltgvflltravlpamlkqssGrIvnvsSvagkvpvagvaaYs 150
                 ++++ +e ++  N  g fllt+++l+ ++k++ GrI+n +Sv ++  ++    Y+
  EFC35543.1 143 TTKQGVELLFGSNHLGHFLLTHLLLNLLKKSKDGRIINLTSVSANSNLEFIEKYA 197
                 88888***************************************99988887775 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 4e-05
                 TTBHHHHHHHHHHHHHHHHHHHHHGGGT...EEEEEEEESSBSSHHHH CS
   adh_short 144 agvaaYsAsKaavagltrslakelaptg...irvnavaPGlvdTdmak 188
                 +++a Y  sK a + ++++l++ela ++   +++ + +PG v+++m k
  EFC35543.1 214 NNFALYRRSKLANILFSKKLSRELALDSsnlVQCYSNHPGTVKSNMGK 261
                 67899*******************9988889**************986 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.7   0.0   4.9e-22   2.2e-18       1     141 [.      53     196 ..      53     199 .. 0.88
   2 ?   -0.5   0.0      0.16   7.3e+02     137     182 ..     215     263 ..     207     269 .. 0.76

  Alignments for each domain:
  == domain 1  score: 66.7 bits;  conditional E-value: 4.9e-22
                   TTT.TSHHHHHHHHHHHTT-EEEEEESSGGHHHHHHHHHHHTT..SE..E.EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH- CS
  adh_short_C2   1 Gaa.sgIGraiAkalaeeGaevvltdlneeakkrveelaeelg..ae..v.lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpflets 91 
                   Ga   gIG+++ k l++ Ga+vvl+ +n+ a ++++el e+ +  ++  + + +D +d ++v+++ e  ++kf++lDil+nnagi+         t+
    EFC35543.1  53 GASaGGIGFETSKVLHRLGATVVLAVRNQLAGDKAKELIEKENgnSDklIvMLIDLADLASVKKFTELFMSKFNQLDILINNAGIMSI-----YGTT 144
                   66669**************************77777777765434336635**********************************997.....889* PP

                   HHHHHHHHHHHTHHHHHHHHHHHHHCTSC..CEEEEEEEGGGTSBSTTTTHH CS
  adh_short_C2  92 reefdraldvnlyslfllakaalplmkeg..gsivnlssvgaervvpnynay 141
                   +++++  +  n  + fll++ +l+l+k++  g+i+nl+sv+a+  ++  + y
    EFC35543.1 145 KQGVELLFGSNHLGHFLLTHLLLNLLKKSkdGRIINLTSVSANSNLEFIEKY 196
                   ************************9998889**********99877666555 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.16
                   TTTHHHHHHHHHHHHHHHHHHHHGG...GTEEEEEEEE--BHCTGGGGS CS
  adh_short_C2 137 nynaygaaKaalealtrylAvelgp...kgiRvNavspgpikTlaasgi 182
                   n + y  +K a + +++ l +el+    + +++ + +pg +k ++ +++
    EFC35543.1 215 NFALYRRSKLANILFSKKLSRELALdssNLVQCYSNHPGTVKSNMGKHM 263
                   5568999999999999999999985222467888888888888887765 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.1     2e-08   9.1e-05       3      93 ..      49     139 ..      47     190 .. 0.90

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 2e-08
                 EEEETT.TSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE------ CS
          KR   3 ylitGG.lGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvlr 93 
                 +++tG+ +Gg+G e+++ l + ga+ +vl  R++ a +++k+li++ + +  +  v+ +D++d ++v++  e + ++++++   i+ Ag++ 
  EFC35543.1  49 VIVTGAsAGGIGFETSKVLHRLGAT-VVLAVRNQLAGDKAKELIEKENGNSDKLIVMLIDLADLASVKKFTELFMSKFNQLDILINNAGIMS 139
                 68999757***************96.6777788789999999***9999999************************************9975 PP

>> Flavodoxin_4  Flavodoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   7.1e-07    0.0032      81     148 ..      24      91 ..      16      95 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 7.1e-07
                   EE-BTTB--HHHHHHHHTS--TT-EEEEEEE-SS--SH.HHHHHHHHH-TTSEE---EE--S---HHHH CS
  Flavodoxin_4  81 fpvwwyiaptiintflesydfagkivvpfatsggsgig.nceknlhkaypdivwkdgkllngqitrdlv 148
                   f   ++  pt+ + +l+s d++gkiv+   +s g gig +  k lh+    +v    + l g+ +++l+
    EFC35543.1  24 FARKYFNGPTVSEKLLKSSDLTGKIVIVTGASAG-GIGfETSKVLHRLGATVVLAVRNQLAGDKAKELI 91 
                   66678889*****************987766655.444267899***9999999999999998888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       588  (0.032796); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 1773.31
//
Query:       EFC35544.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.8e-16   59.2   8.1      2e-14   53.9   8.1    2.2  1  Glyco_transf_34  galactosyl transferase GMA12/MNN10 family
    0.00041   20.0   0.4    0.00055   19.6   0.4    1.2  1  DUF273           Protein of unknown function, DUF273
  ------ inclusion threshold ------
      0.057   13.1   0.1       0.12   12.0   0.1    1.5  1  DUF3146          Protein of unknown function (DUF3146)


Domain annotation for each model (and alignments):
>> Glyco_transf_34  galactosyl transferase GMA12/MNN10 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.9   8.1   3.3e-18     2e-14      32     235 ..       5     177 ..       1     181 [. 0.79

  Alignments for each domain:
  == domain 1  score: 53.9 bits;  conditional E-value: 3.3e-18
  Glyco_transf_34  32 NrvdYaekhgyeifykkvsallaeemnsvWaklpairaamkkyPeaewiWwlDqdAlimnmdlsleehvlkperLeelllkntpvvplrryket 125
                      N++ Y+ kh+y+++  +   +++  ++ +W+k+p+i+  + +y   +wi w+D+dAl++  ++           L++++    + +p+++    
       EFC35544.1   5 NKIFYSLKHNYDFILFNQPFYKSWFVKPAWNKIPLIKSQLSSY---DWIIWIDSDALVLLHQVD----------LDQIIEESLKRDPNKN---- 81 
                      9**************9999999999*****************9...9************99999..........3333333333334443.... PP

  Glyco_transf_34 126 nlvedgedvlviisqdwnglnagsflirnsewsklllDlwadpllrekkkavtesdeqsaleyllekhpevlskvglveqkvinsydegekelg 219
                             ++++iis d ngln+g + irn++ws ++l+      +  +       +eq+ l   le  +    +v    + ++nsy  +     
       EFC35544.1  82 ------GEINLIISYDRNGLNSGIMAIRNCKWSHQILNNVLSWKYFLYSMH--WYAEQTPLVMELEHGKSQNVRV--ALKSFLNSYMYD----- 160
                      ......4899***************************97664444443333..359***9987777666655555..45899****877..... PP

  Glyco_transf_34 220 ykeg.dlvvhfagCkva 235
                      ykeg  ++ h+agC++ 
       EFC35544.1 161 YKEGkSFIFHLAGCNKY 177
                      555427********975 PP

>> DUF273  Protein of unknown function, DUF273
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.4   9.2e-08   0.00055       4     116 ..       9     129 ..       7     176 .. 0.79

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 9.2e-08
      DUF273   4 yakihgyefilaedtdyeCeqkdkffrrhCvvakilpkydavlfldadigvvnpk....rkleefle....eeidivlydrfynweiaagsylvkntey 94 
                 y+ +h+y+fil ++  y+    +  + +  ++   l++yd ++++d+d  v+  +    + +ee l+    ++ +i l   +    ++ g   ++n ++
  EFC35544.1   9 YSLKHNYDFILFNQPFYKSWFVKPAWNKIPLIKSQLSSYDWIIWIDSDALVLLHQvdldQIIEESLKrdpnKNGEINLIISYDRNGLNSGIMAIRNCKW 107
                 8899**************9999999************************99888722224445544322213456888888888899999999****** PP

      DUF273  95 avdlleefadyesklPksfhgt 116
                 + ++l++   ++  l ++   +
  EFC35544.1 108 SHQILNNVLSWKYFLYSMHWYA 129
                 ******9988887776555555 PP

>> DUF3146  Protein of unknown function (DUF3146)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1     2e-05      0.12       8      77 ..     101     171 ..      97     173 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2e-05
     DUF3146   8 ritkqswqegkleGeveageyeWqfkWafrkgeLsvePslGraL.ikepLerflekkDyqLepGgdYeftv 77 
                  i +  w+++ l+  ++ + + ++ +W  ++  L +e   G++  ++ +L+ fl+   y    G+ + f +
  EFC35544.1 101 AIRNCKWSHQILNNVLSWKYFLYSMHWYAEQTPLVMELEHGKSQnVRVALKSFLNSYMYDYKEGKSFIFHL 171
                 677888999999999999************************854899*****************999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1278.43
//
Query:       EFC35545.1  [L=101]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (101 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.38u 0.26s 00:00:00.64 Elapsed: 00:00:00.41
# Mc/sec: 730.77
//
Query:       EFC35546.1  [L=272]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1264  (0.0705003); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.24s 00:00:00.71 Elapsed: 00:00:00.42
# Mc/sec: 1963.67
//
Query:       EFC35547.1  [L=109]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.36u 0.27s 00:00:00.63 Elapsed: 00:00:00.41
# Mc/sec: 799.10
//
Query:       EFC35548.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       797  (0.0444531); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 2296.71
//
Query:       EFC35549.1  [L=631]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.2e-06   25.9   0.0    2.3e-05   24.3   0.0    1.8  2  Phage_integrase  Phage integrase family
  ------ inclusion threshold ------
      0.055   13.7   1.9       0.33   11.1   0.1    3.0  3  DUF2666          Protein of unknown function (DUF2666)


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0      0.76   6.8e+03     101     119 ..     172     194 ..     140     207 .. 0.52
   2 !   24.3   0.0   2.6e-09   2.3e-05      35     167 ..     470     613 ..     437     616 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 0.76
                      T....TSSB--HHHHHHHHHHHH CS
  Phage_integrase 101 k....rgkplsrqtvrkafkrav 119
                           r ++++++ ++k+++ ++
       EFC35549.1 172 SrnypRLQEIQSKGLQKMMEMLH 194
                      03333444444444444444444 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 2.6e-09
                      --HHHHTT-BGGGEE.CTTTEEEEE.................EEECSSSSEEEEECTHHHHHHHHHHHHHHCHCCTTTSBSSBETTSSB--HHH CS
  Phage_integrase  35 lRisEllsLrvkdld.lengvilvh.................eregKgskeravplseealellkellskaleeaeksellfaskrgkplsrqt 110
                      +R +E+++L+++ ++ l+ng i+++                  +++K+     ++l ++++ l++e  ++        + lf  +++k l +++
       EFC35549.1 470 ARPGEVARLKWSYIKvLKNGKIKIDlsghktdffliekpitiDKNTKNPSLCPITLLNSYMDLVREFKDDD-------SPLFSYENNKFLDSND 556
                      799**********8736899****98888888888876643333333333344444466666666666666.......9*************** PP

                      HHHHHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHHHHT-SSCCHHHHHH CS
  Phage_integrase 111 vrkafkraveeagiekpltpHtlRhsfataLleagvdlrvvqkllGHssisttqiYt 167
                      ++k++k+av   + + ++++H++R  + t+ l++gv+++ ++    H+  ++   Y 
       EFC35549.1 557 ISKILKNAVGMVDQDVRVSGHSIRIGAITEGLRKGVSTSDLMVGARHKKTNSLFPYL 613
                      ******************************************999999988876666 PP

>> DUF2666  Protein of unknown function (DUF2666)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2      0.21   1.9e+03      85     126 ..     249     290 ..     226     294 .. 0.73
   2 ?   11.1   0.1   3.7e-05      0.33      27     111 ..     372     459 ..     355     467 .. 0.77
   3 ?   -0.9   0.0       0.2   1.8e+03       9      30 ..     498     520 ..     491     535 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.21
                 T-.............---HHHHHHHHHHHHHTTT--SS--HH CS
     DUF2666  85 spattkklnkitdskegkeilkvilarivLerlGiktkvesk 126
                  +  ++ +++it++ + k+ +k ++++ + +++  ++k++ k
  EFC35549.1 249 PFIQSNTFADITEKARQKKREKSVVKHAITSKIQKPLKMKEK 290
                 555666777888888888888888888888887666665554 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 3.7e-05
                 HHHHHHHHHHHH....HHHHHHHHHHTT--HHHHHHHTTT--S--S....HHHHHHHHHHHHT-.............---HHHHHHHHH CS
     DUF2666  27 dleiarlLasie....etvskkikdylpfDlekleeiadeikkkkkgrvkeedisevleklkspattkklnkitdskegkeilkvilar 111
                 +  i+ lL+ i+     tv+  i+ ++++D + ++ i   + k+kkg +k   +s+ ++  ++p t k+l++  + k+  +     l+ 
  EFC35549.1 372 EYYISYLLINIQgykaKTVQAAIQFFANLDGKPIT-ISASYSKVKKGVLKLYTLSDKVSLQRDPITVKHLTDYVKCKDKVDNFTFRLTS 459
                 456788888886444479*************9997.5567899*************************999988887766655555554 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.2
                 EETTE.EEEEEEE--TTS-HHHH CS
     DUF2666   9 kkgkW.ivvkklkiDektedlei 30 
                 +k  + ++ k + iD +t++  +
  EFC35549.1 498 HKTDFfLIEKPITIDKNTKNPSL 520
                 444440566889******98655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (631 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       974  (0.0543254); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.41
# Mc/sec: 4662.76
//
Query:       EFC35550.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-54  185.1   2.5    1.5e-54  184.9   2.5    1.1  1  DUF924    Bacterial protein of unknown function (DUF924)


Domain annotation for each model (and alignments):
>> DUF924  Bacterial protein of unknown function (DUF924)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  184.9   2.5   8.3e-59   1.5e-54       1     179 [.      49     237 ..      49     238 .] 0.92

  Alignments for each domain:
  == domain 1  score: 184.9 bits;  conditional E-value: 8.3e-59
      DUF924   1 vldfWfeeeakekakrwfkkkeefDaeirerfesllea..........aaagelde..wakepegaLaliillDQfpRniyRgtakafatDalAlalak 87 
                 vl+fWf+   ++ +++wfk+++++D+ i++ fes+++a          ++ +e+d+   ++++e+ L+ +i+lDQfpRn+yR++ak+fa+D++A++l+ 
  EFC35550.1  49 VLEFWFQG-DMAPQQWWFKSSPTIDQGIKKLFESHVAAlsnklellfeKSFEEIDAvlKKQSKETLLSAMIMLDQFPRNMYRNSAKSFAFDDVAVKLSL 146
                 89******.6999*************************99999999974444455421335589*********************************** PP

      DUF924  88 ealekgldeelee.aerlffylplmHsEdladqeravelfeelaeeveeeeeeeslkfakkhrdiierFgRyPhRNaaLgResteeEkefLee 179
                  ++e+++d+++e   ++++fy+pl+H+Ed++ q++++elf +l ee+e++  + + k+a +hr++i++FgR+P+RN+aLgRest+eE+e+Le+
  EFC35550.1 147 WCIENQIDQQFEFpLQKIWFYFPLEHAEDAELQDMSCELFGKLVEEHEAM--ALFNKYAINHREVIQKFGRFPYRNKALGRESTPEEIEYLES 237
                 ***********9559******************************88887..99*************************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       581  (0.0324056); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 1738.57
//
Query:       EFC35551.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-57  194.6   0.6    2.2e-57  194.4   0.6    1.0  1  PhoPQ_related  PhoPQ-activated pathogenicity-related protein


Domain annotation for each model (and alignments):
>> PhoPQ_related  PhoPQ-activated pathogenicity-related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  194.4   0.6   1.2e-61   2.2e-57       3     214 ..      52     271 ..      50     277 .. 0.89

  Alignments for each domain:
  == domain 1  score: 194.4 bits;  conditional E-value: 1.2e-61
  PhoPQ_related   3 dyvek.edeelkyeltetkeleg.vtiyileltSQkWskeklvdpslwkHkltivvPkekkleetalllisggsnenvkkkskesesetlaeiare 96 
                    dy++  ++e++ky+l +++ + + +++y++++tS kW ++k+v++s+w H ++ivvP + +++++al+li+ggs    ++ ++++ ++ l ++   
     EFC35551.1  52 DYMKDrSNENFKYQLLNSVDIPNtAKFYVFNMTSVKWLTNKEVSRSEWYHFVEIVVPYQITQTKQALMLIAGGS----SNSQVPTLDKELIQMGVL 143
                    899988999**********998779*************************************************....445555667779999*** PP

  PhoPQ_related  97 tkavvaelsdvPnqpltfeddgk..arkEDdlvAytwrkfle..eekde.....tlplllpmtkaavraMdlvqeflkel.klkiekFvvsGaSKR 182
                    tk++v +++++Pnqpltf  d++  +r ED+++A++w++f++  +e+de     ++  +lpm+k++  aMdlvqe l +  ++k+e+F v+GaSKR
     EFC35551.1 144 TKSIVCTIHQIPNQPLTFLSDPEkkSRVEDAILAFAWARFMNltQENDElksntEWIPRLPMVKSTLFAMDLVQEYLLKNlNIKVEDFHVAGASKR 239
                    ******************8876533789*************97644443222227999*****************986666*************** PP

  PhoPQ_related 183 GWttwltaivDkrvkaivPvvidilnlekqlk 214
                    GWtt l+++vD+rvk+i+P+vi+i+ ++++l+
     EFC35551.1 240 GWTTNLVGVVDQRVKSIIPIVIPIWKTREVLG 271
                    ****************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       696  (0.0388198); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.25s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 2053.74
//
Query:       EFC35552.1  [L=614]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-09   37.8   0.0      1e-07   32.0   0.0    2.3  2  Peptidase_M16  Insulinase (Peptidase family M16)


Domain annotation for each model (and alignments):
>> Peptidase_M16  Insulinase (Peptidase family M16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.0   0.0   5.8e-12     1e-07      27     119 ..      57     145 ..      53     160 .. 0.88
   2 !    3.3   0.0    0.0041        73      61     127 ..     251     317 ..     248     334 .. 0.82

  Alignments for each domain:
  == domain 1  score: 32.0 bits;  conditional E-value: 5.8e-12
                    CTTTTTHHHHHHHHTTSBBSSSCHHHHHHHHHHTTCEE..EEEEESSEEEEEEEEEGGG.HHHHHHHHHHHHHSBTTSHHHHHHHHHHHHHHHHHH CS
  Peptidase_M16  27 pkdlnGlAHllehmafkgTkkypsnklaeeleklGgsl..nAttsrentvYyvevlskd.lekaldvladvfkaplleesevererkvvekeveav 119
                    p d  G+ H leh++f+g+++yp +++   +++   ++  nA+t+  nt+Y ++++ k+ +  +l v  d +  p+l+++++ +       e+ ++
     EFC35552.1  57 PADHDGIPHVLEHLIFMGSEEYPYKGILDKVANRCFAQgtNAYTQNTNTTYELTTAGKEgFYRLLPVYLDHILYPTLSDNAFIT-------EIHHI 145
                    67889*******************9999999999999889************98876666*****************9999887.......55554 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.0041
                    TCEEEEEEESSEEEEEEEEEGGGHHHHHHHHHHHHHSBTTSHHHHHHHHHHHHHHHHHHCCHHHHHH CS
  Peptidase_M16  61 GgslnAttsrentvYyvevlskdlekaldvladvfkaplleesevererkvvekeveavdaepekvv 127
                    G +l+A    e   ++++++ ++ ek+++   ++++++  +++ +e++ +v++ ev+  +  pe v+
     EFC35552.1 251 GKNLQAGLFAELVQFQLTFELDKYEKMIAWARNFLYNTVYTPEVIETKIQVLLSEVQLHKITPESVL 317
                    55678888889999*********************************88899999887666664444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (614 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       464  (0.0258799); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 3884.11
//
Query:       EFC35553.1  [L=255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.8e-19   68.7   1.3    5.2e-19   68.3   1.3    1.2  1  Glyco_hydro_71  Glycosyl hydrolase family 71


Domain annotation for each model (and alignments):
>> Glyco_hydro_71  Glycosyl hydrolase family 71
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.3   1.3   2.9e-23   5.2e-19     207     374 ..      20     174 ..       3     175 .. 0.87

  Alignments for each domain:
  == domain 1  score: 68.3 bits;  conditional E-value: 2.9e-23
  Glyco_hydro_71 207 lwakRweqvlelqpdfveiitWNDygEShYigplkekkaqdgsskyvegmpHdgwrdllkyyiaayKtgskkpaitedklvlwyRphpkkakcss 301
                      + + w + l+++ d+v + tWND+ ES  + p+ +           ++   +g+ dl++yy+++++tg + p+i +d ++++yR + ++a + +
      EFC35553.1  20 AYRNAWMSTLQTNADIVHVATWNDFSESGQLQPITD----------LQNTTGNGFYDLTAYYAHWWRTGLQ-PTIIRDVVYYFYRKEATNAYAPN 103
                     56777999999999*******************998..........4567789****************87.*******************9966 PP

  Glyco_hydro_71 302 gdttgnpanaelleDkvfvvallkspatvtvsvggkesetfsvkaGvnklsvpfngetGkvkvsvvrngktva 374
                      +        + +++++ v++++++++ +t+ + +++++ +  ++G+n++ +p+  ++Gk++++++rng +++
      EFC35553.1 104 MGCNFTMGISQSVSNQIEVLTFTTDQSILTIIIENSNYTFMINSSGINSFFIPL--QAGKPNIQLWRNGINII 174
                     655555555599**********************9999655557**********..************98875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       704  (0.039266); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.29s 00:00:00.72 Elapsed: 00:00:00.43
# Mc/sec: 1772.78
//
Query:       EFC35554.1  [L=588]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-22   80.2   0.0      3e-21   76.1   0.0    2.1  1  CHAT      CHAT domain


Domain annotation for each model (and alignments):
>> CHAT  CHAT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.1   0.0   1.7e-25     3e-21       1     266 [.     309     558 ..     309     579 .. 0.79

  Alignments for each domain:
  == domain 1  score: 76.1 bits;  conditional E-value: 1.7e-25
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        CHAT   1 qksaraLydlliaPleaeldgqsvrqlvivpdg.eLqliPfealvdpdgrylleryavsyapsarllselrkaaasaasalqlvvgdpkfdaaellrkl 98 
                 qk ++ Ly +li+P+e+el      +++i+p++ +   +Pf al+d+dg++l+e+y++s       +s+ +  +++ +      ++ ++  ++      
  EFC35554.1 309 QKHLQLLYSKLIEPIEEEL----KHEIIILPSDgAEAFFPFFALRDKDGNFLIEKYKIS-------FSTFPPTKKVGKDN----IKTACILDS------ 386
                 678999********88887....558888888768899*********************.......66666555555555....555555555...... PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xxxxxxxxxxxxxxxxx....... RF
        CHAT  99 vfpelpgteaEaeaiakllaegelkvllgeaatesalksalsrryrvvHfatHgvfn..................anpplqsglvlsaense....... 172
                   ++l+ + +E + i+++l  +     +++   +++l++      +vvH+a H  ++                   n              e       
  EFC35554.1 387 --EDLKHSIHESNSIKETLMGR----GVQCYSKAENLEEC-----NVVHLAMHSNATselmegenfqdtilswlkGN--------------Efmatgql 460
                 ..89**************9554....34444445555555.....7***********99998744444444444433..............13455566 PP

                 ...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxx RF
        CHAT 173 ...edglLtaeeilelnldgaelVvLsACqtglgevidgegvlgLaralllaGarsviaslwpVddeatalLmkrfyqnlla.glskaeALreaqlkl 266
                      ++L a  + e  l++++lVv+s+C++g g+   geg+lg+++ +l++G+ +vi +  +V+d++ + Lm  fy+ l + ++++  + r a l+ 
  EFC35554.1 461 frnGKQFLHATSFGEKCLSKIKLVVFSSCNSGKGKYVPGEGLLGFVYNALISGVDCVISTGSEVNDAYMRILMSDFYKCLTTtNMDVGSSIRSAILQN 558
                 655899*********89999**********************************************************99998666666666665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (588 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.44
# Mc/sec: 3991.06
//
Query:       EFC35555.1  [L=312]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (312 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       600  (0.0334653); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 2122.97
//
Query:       EFC35556.1  [L=332]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.099   12.9   0.0         13    6.0   0.0    2.5  2  Med22     Surfeit locus protein 5 subunit 22 of Mediator comp


Domain annotation for each model (and alignments):
>> Med22  Surfeit locus protein 5 subunit 22 of Mediator complex
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0   0.00073        13      71     104 ..     107     140 ..      87     141 .. 0.91
   2 ?    4.2   0.0    0.0027        48       2      21 ..     184     203 ..     183     217 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.00073
       Med22  71 fpelneeikdqeeeldeeneelsqllnnlreelt 104
                 ++e+n +++++++++++++ e +qll+++ ++++
  EFC35556.1 107 VKETNPQNQARNNGVGSTTVEFNQLLFKMTDKIV 140
                 5789**************************9986 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0027
       Med22   2 rldddveslldnfrelikla 21 
                 +ldd+++ l +nf+++ kl 
  EFC35556.1 184 KLDDNIKRLWRNFQDVWKLC 203
                 89*************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (332 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       851  (0.047465); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.25s 00:00:00.74 Elapsed: 00:00:00.42
# Mc/sec: 2351.74
//
Query:       EFC35557.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.4e-18   64.9   0.0    1.6e-17   64.0   0.0    1.5  1  IPK       Inositol polyphosphate kinase


Domain annotation for each model (and alignments):
>> IPK  Inositol polyphosphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.0   0.0   8.9e-22   1.6e-17       1      61 [.     176     234 ..     176     235 .] 0.97

  Alignments for each domain:
  == domain 1  score: 64.0 bits;  conditional E-value: 8.9e-22
                 EEEEE-TTTT-SSEEEEEEEESSSSS-TTSTCHHHHHHHHHHCCSTHHHHSEEEEEEEEEE CS
         IPK   1 ylvLedltagfkkPcvlDvKlGtrtydedaseekrekqqkkskettseslGfrilGmkvyk 61 
                 ++vLed+ta++++P+v+D+K+G+rty+edas++k+ + ++k  +  +++lG+ri+G k+y+
  EFC35557.1 176 FIVLEDITANMDHPNVMDIKMGQRTYGEDASPQKILEEESK--YVYQHQLGMRISGAKIYD 234
                 79************************************999..****************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       553  (0.0308439); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.24s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 1767.82
//
Query:       EFC35558.1  [L=177]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   14.6   1.0      0.099   11.7   0.1    2.0  2  DUF898    Bacterial protein of unknown function (DUF898)
       0.16   11.8   2.5       0.27   11.1   2.5    1.4  1  DUF728    Protein of unknown function (DUF728)


Domain annotation for each model (and alignments):
>> DUF898  Bacterial protein of unknown function (DUF898)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   1.1e-05     0.099     133     172 ..      40      79 ..      25      86 .. 0.85
   2 ?    1.7   0.1     0.012   1.1e+02     119     155 ..     121     157 ..     116     168 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.1e-05
      DUF898 133 aflllpllalltlglalpfaearlkrylvsntrfGasrfk 172
                  + l+   a+lt+g+++pf+++ ++  +++++r+G+ +f 
  EFC35558.1  40 LYTLMKTCAILTFGFLYPFVHQYYNPKFLEQVRYGRGQFV 79 
                 5677788899***************************996 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.012
      DUF898 119 lrfgfdgslgeaykaflllpllalltlglalpfaear 155
                  rf++++++ +++ +++l  ++  +t+g+  +  +++
  EFC35558.1 121 MRFEWTADTTDMFCRYFLGAVINNFTFGFFRCCYWYW 157
                 5777888888888888888888888887777666665 PP

>> DUF728  Protein of unknown function (DUF728)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   2.5     3e-05      0.27      41      65 ..     129     153 ..     119     166 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 3e-05
      DUF728  41 caenncgwfvcvvindftfdvyncc 65 
                  ++  c +f+  vin+ftf  + cc
  EFC35558.1 129 TTDMFCRYFLGAVINNFTFGFFRCC 153
                 56778******************** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       492  (0.0274416); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.24s 00:00:00.64 Elapsed: 00:00:00.41
# Mc/sec: 1309.23
//
Query:       EFC35559.1  [L=100]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        0.4   10.8   5.0        3.9    7.7   0.9    2.2  2  Herpes_UL49_2  Herpesvirus UL49 tegument protein


Domain annotation for each model (and alignments):
>> Herpes_UL49_2  Herpesvirus UL49 tegument protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.9   0.00021       3.9      18      58 ..      28      68 ..      15      75 .. 0.79
   2 ?    5.9   0.5   0.00074        13      42      63 ..      71      92 ..      58      95 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00021
                   --S-SSSTTS---HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Herpes_UL49_2 18 fstaPasasssWrsttaafnkrvFceavsrvaaaqaekaae 58
                   + +a ++a+ +W +tt a+n  ++ +a         ++a  
     EFC35559.1 28 YNAAFNAATTPWMATTGAYNPALYSNAYMGANSFTPYLATS 68
                   56788999**************9999976666555555555 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.00074
                   HHHHHHHHHHHHHHHHHHHHHH CS
  Herpes_UL49_2 42 ceavsrvaaaqaekaaealWek 63
                      +  +a +qa  aa + W +
     EFC35559.1 71 TSTIPILANMQASSAAFNTWST 92
                   5567789*************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (100 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.37u 0.25s 00:00:00.62 Elapsed: 00:00:00.41
# Mc/sec: 732.21
//
Query:       EFC35560.1  [L=149]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.084   12.8   0.0       0.13   12.2   0.0    1.4  1  DUF4743   Domain of unknown function (DUF4743)


Domain annotation for each model (and alignments):
>> DUF4743  Domain of unknown function (DUF4743)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   7.4e-06      0.13      27      70 ..      19      62 ..       4      82 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 7.4e-06
                EEEEEEEHHHHHHHCT-TTTEEE-SS.EEEE-TT--SHHHHHHH CS
     DUF4743 27 qqvGlirpdvaeklrkfpdvFevsekeaveLapslktyeeRtaa 70
                +  G+++++ + +l+k+++vF++++   +++ p+ k+ ++Rt++
  EFC35560.1 19 HMFGILKSQKTIQLSKHESVFCLTSGIDLQFTPTKKQTKKRTNK 62
                7889**********************99999**********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1603  (0.0894082); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.27s 00:00:00.68 Elapsed: 00:00:00.42
# Mc/sec: 1056.81
//
Query:       EFC35561.1  [L=305]
Description: hypothetical protein NAEGRDRAFT_60085 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       568  (0.0316805); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 2199.70
//
Query:       EFC35562.1  [L=105]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-26   91.6   0.0    4.6e-26   91.3   0.0    1.1  1  Ras       Ras family
    1.2e-12   48.1   0.0    1.4e-12   47.9   0.0    1.1  1  Roc       Ras of Complex, Roc, domain of DAPkinase
     0.0019   17.7   0.0     0.0019   17.6   0.0    1.1  1  Arf       ADP-ribosylation factor family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.3   0.0   7.7e-30   4.6e-26       1      78 [.       6      82 ..       6      86 .. 0.99

  Alignments for each domain:
  == domain 1  score: 91.3 bits;  conditional E-value: 7.7e-30
                EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEE CS
         Ras  1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillv 78
                Klv+vGd+avGK++ll+  ++++F+e+y +T+ +d+y++++++ ++++++ +wDTAGqe++++lr+l+y ++++++++
  EFC35562.1  6 KLVVVGDGAVGKSCLLIASTTNSFPEDYVPTV-FDNYSANVTYGNRNYNVGLWDTAGQEDYDRLRPLSYPGTDVFFVC 82
                9*******************************.******************************************998 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.9   0.0   2.4e-16   1.4e-12       1      85 [.       6      81 ..       6      94 .. 0.85

  Alignments for each domain:
  == domain 1  score: 47.9 bits;  conditional E-value: 2.4e-16
                EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEE CS
         Roc  1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalail 85
                K+v+vGd++vGK++ll   ++++f e++ +t+  +++  +vt   g  n    +++++ +WDtaGqe+++ l+pl + + +++++
  EFC35562.1  6 KLVVVGDGAVGKSCLLIASTTNSFPEDYVPTVFDNYSA-NVT--YG--N----RNYNVGLWDTAGQEDYDRLRPLSYPGTDVFFV 81
                99******************************888865.442..22..2....46899****************99988887765 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   3.2e-07    0.0019      13      79 ..       3      73 ..       1      93 [. 0.80

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 3.2e-07
                TEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEE.EEEEEE..TTEEEEEEEE-SSGGGGGGGGGGC CS
         Arf 13 kelrilllGLDnaGKtTilkklkleelvt.tvPTigfn.veelei..knlkftvwDvGGqeklRplWknYf 79
                ++l+++++G  + GK+ +l   +++++ +  vPT+  n + ++++  +n+++ +wD  Gqe   +l    +
  EFC35562.1  3 NSLKLVVVGDGAVGKSCLLIASTTNSFPEdYVPTVFDNySANVTYgnRNYNVGLWDTAGQEDYDRLRPLSY 73
                6799*****9999*******99999997659***98883568999556777888******97666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       232  (0.0129399); expected 358.6 (0.02)
Passed bias filter:                      210  (0.0117129); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.41u 0.26s 00:00:00.67 Elapsed: 00:00:00.44
# Mc/sec: 724.49
//
Query:       EFC35563.1  [L=109]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       537  (0.0299515); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.40u 0.25s 00:00:00.65 Elapsed: 00:00:00.43
# Mc/sec: 767.89
//
Query:       EFC35564.1  [L=192]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.4e-63  214.5   0.2    2.9e-63  214.2   0.2    1.0  1  Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase famil


Domain annotation for each model (and alignments):
>> Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  214.2   0.2   1.6e-67   2.9e-63      35     219 ..       6     188 ..       2     192 .] 0.90

  Alignments for each domain:
  == domain 1  score: 214.2 bits;  conditional E-value: 1.6e-67
                   HHHHHHHHHHHHHTT-SEEEEEEEESSCCC-SCTTSEE-SSGGGHHHHHHHHHHHHHTT-EEEEEEE--GGGS..SCSTCEC...SS.ESSSSSTTT CS
  Oxidored_FMN  35 edlaaeyysqraeipvtliiteaafvnpksggfdnapgiwdeeqieewrklteavhengskvvvqlwhlGreakseyladqe.vdspsdpvaldaqe 130
                   +d+ a yy+qra+ +++lii+ea+ ++p+++g++  pg+++e q+++w+k+t+avh++g+ +++qlwh Gr   ++++   +   +    ++l+  e
    EFC35564.1   6 TDVGAIYYNQRAS-KGGLIIAEASQITPQGQGYPFTPGCYSEAQVKAWKKITDAVHQKGGIIFLQLWHVGRVRYADSVSSSDiAMTQLSCFNLKTFE 101
                   567788*******.99*********************************************************999999999422223344555555 PP

                   -.S...CS-EE--HHHHHHHHHHHHHHHHHHHHTT-SEEEEEE-CTSHHHHHH-TTT----STTSSSHHHHHHHHHHHHHHHHHHH-SS CS
  Oxidored_FMN 131 eesaeevykkeltkeeikqliqefveAAkraieAgfDgVeihganGYLlnqFlspksnkrtDeygGslenRarFllevvdaVkeavgee 219
                   +++ae+   k+l+ eeik +++++  AAk+aieAgfDgVeihganGYL++qF++ + nkrtDeygGs+enR+rF++evv++V +av  e
    EFC35564.1 102 QVTAEPP--KSLSVEEIKTIVEQYGAAAKNAIEAGFDGVEIHGANGYLIDQFIQDGVNKRTDEYGGSIENRLRFMREVVESVLKAVNGE 188
                   5667776..****************************************************************************9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       560  (0.0312343); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1269.12
//
Query:       EFC35565.1  [L=218]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.4   0.0       0.31   11.0   0.0    1.7  1  SUV3_C    Mitochondrial degradasome RNA helicase subunit C te


Domain annotation for each model (and alignments):
>> SUV3_C  Mitochondrial degradasome RNA helicase subunit C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   1.7e-05      0.31      25      45 ..     121     141 ..     115     143 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.7e-05
                 ---HHHHHHHHHHHHHHHHHH CS
      SUV3_C  25 FpdrelaeelkkeveekIeea 45 
                 Fpd+++a++++k   + Iee+
  EFC35565.1 121 FPDEDWANHMRKVAISNIEEI 141
                 9*************9999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       368  (0.0205254); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.52
# Mc/sec: 1261.52
//
Query:       EFC35566.1  [L=266]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00016   21.8   0.1    0.00025   21.2   0.1    1.2  1  MACPF     MAC/Perforin domain


Domain annotation for each model (and alignments):
>> MACPF  MAC/Perforin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.1   1.4e-08   0.00025     144     209 .]      28      88 ..      21      88 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 1.4e-08
                 HH---EEEEEESS-GGG----HHHHHHHHHHTTTS-EEEEEEEEEGGGGS-TT-HHHHHHHHHHHH CS
       MACPF 144 qesessktlviGGepeseddksktyseWaesvkenpmpIklelvPisellkeeekkeslkkaleeY 209
                 q+++ s++++ GG+p    ++  ++    +s+ +np+pIk+e  Pi + ++  +k+e++k a+ +Y
  EFC35566.1  28 QYHKISQLDIAGGNP----QDD-NIPRRVQSIRTNPVPIKFESSPIWTVFPAGTKRENMKTAYYNY 88 
                 566777888999998....333.4445589********************************9888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       565  (0.0315132); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.25s 00:00:00.67 Elapsed: 00:00:00.40
# Mc/sec: 1976.63
//
Query:       EFC35567.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.1e-20   71.6   0.7    8.2e-20   71.4   0.7    1.0  1  TLD       TLD
     0.0034   17.3   0.0     0.0062   16.5   0.0    1.5  1  Kelch_4   Galactose oxidase, central domain


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.4   0.7   9.2e-24   8.2e-20       2     138 ..      13     162 .]      12     162 .] 0.82

  Alignments for each domain:
  == domain 1  score: 71.4 bits;  conditional E-value: 9.2e-24
         TLD   2 lyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkss.nkkfygdsesflfsl.....spkfkvyks.....tgkn.kaylntssdglg 88 
                 ly++s+dg++ ++++ k++n+g t+++ik + + ifG+++s  w+ +  ++f  +++ flfsl     + +fk +++     ++++   ++++s+ g++
  EFC35567.1  13 LYKASRDGFQSKQFHTKCDNQGATVTIIKADTGAIFGGYTSAAWNTTvMSQFAYSERAFLFSLvsnsgEERFKKLNQlappnSPSQgRSIYSHSRFGPT 111
                 8*******************************************5441458**************99977888888776655333355666666679** PP

         TLD  89 fGggqpkfsLwidsslekgtsrhs.....etfengllsgaseerfkikdiEVWgl 138
                 fGgg   ++L+i s+ +++t + +       f+ + l+g s ++  +kdiEV++l
  EFC35567.1 112 FGGG---HDLYICSNAHENTGSYChpntyADFGKEYLAG-SYKEWLVKDIEVYSL 162
                 **95...79999999888766666664666677999996.99**********975 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0     7e-07    0.0062       3      40 ..      33      79 ..      32      97 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 7e-07
     Kelch_4  3 aghsatsipdgtiylfGGrgedg.........tllndlylldlstnt 40
                +g+++t i  +t ++fGG+++ +         + +  ++l++l +n+
  EFC35567.1 33 QGATVTIIKADTGAIFGGYTSAAwnttvmsqfAYSERAFLFSLVSNS 79
                689******************88999999999999999999999994 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       578  (0.0322383); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.31s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 1035.19
//
Query:       EFC35568.1  [L=241]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0029   17.2   6.3     0.0041   16.8   6.3    1.2  1  SR-25       Nuclear RNA-splicing-associated protein
  ------ inclusion threshold ------
       0.71    8.6   7.1       0.84    8.3   7.1    1.1  1  Presenilin  Presenilin
          1    8.5   2.8        1.1    8.4   2.8    1.1  1  Zip         ZIP Zinc transporter
        7.6    6.3   6.9         15    5.3   6.9    1.4  1  DUF3464     Photosynthesis affected mutant 68


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   6.3   9.2e-07    0.0041      62     124 ..      13      75 ..       1      96 [. 0.46

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 9.2e-07
       SR-25  62 rssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkakekakaea 124
                 +++s+++     s+ ++++++sss+  ++++ kk+++k +++++ kk+kk+  k+++++k++ 
  EFC35568.1  13 TTTSTTDVTTVGSTTTTTTTISSSELVNEQNDKKRKNKFNNNNNNKKNKKQNNKQQNSNKERD 75 
                 334444444444444444444444444555555444444444443444444444443333322 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   7.1   0.00019      0.84     238     312 ..       5      80 ..       1     128 [. 0.50

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00019
  Presenilin 238 eeeaekkkeeasesskeeeseeesseksaqsse..seeeseeesseaessaeesseekeseessesseeeeeeeeee 312
                 ++e+++  +++s+++ ++  ++++++++ +sse  +e+++++++++ ++++++++++k+ ++++++s++e+++e+++
  EFC35568.1   5 QQETTTIPTTTSTTDVTTVGSTTTTTTTISSSElvNEQNDKKRKNKFNNNNNNKKNKKQ-NNKQQNSNKERDDEDAD 80 
                 22222222222222222222222222222222243333333333333333333333333.33333333333333333 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   2.8   0.00024       1.1     106     179 ..       5      78 ..       2     168 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00024
         Zip 106 hkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqaseeedkekl 179
                 ++e+t+ ++++s++   +++s    +++ s+    +++++++++++  +  n+k++k++++k+q+s++e++ ++
  EFC35568.1   5 QQETTTIPTTTSTTDVTTVGSTTTTTTTISSSELVNEQNDKKRKNKFNNNNNNKKNKKQNNKQQNSNKERDDED 78 
                 56677777777777777777777777777777777777777777777777777777777777776643333333 PP

>> DUF3464  Photosynthesis affected mutant 68
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   6.9    0.0033        15       9      45 ..      41      78 ..      32      91 .. 0.44

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0033
     DUF3464  9 ep.kkkrkkkpkkkkkskkakkeekekakeeekkdkee 45
                e+  kkrk+k ++++++kk+kk++++++++++++d+e+
  EFC35568.1 41 EQnDKKRKNKFNNNNNNKKNKKQNNKQQNSNKERDDED 78
                44123333333333333333333333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3232  (0.180267); expected 358.6 (0.02)
Passed bias filter:                      879  (0.0490267); expected 358.6 (0.02)
Passed Vit filter:                       165  (0.00920297); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.38s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 1320.13
//
Query:       EFC35569.1  [L=247]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.049   14.0   1.1       0.15   12.5   0.0    2.2  3  HCMV_UL139  Human Cytomegalovirus UL139 protein
       0.21   10.1   9.4       0.23   10.0   9.4    1.1  1  Macoilin    Macoilin family
       0.33    9.4  13.1       0.39    9.2  11.1    1.7  2  LRIF1       Ligand-dependent nuclear receptor-interacting fac
        1.1    9.3   4.9        2.1    8.4   4.9    1.5  1  Med26_C     Mediator complex subunit 26 C-terminal
          3    7.1   5.4        4.2    6.6   5.4    1.1  1  FAM76       FAM76 protein
        5.2    7.9   8.0         39    5.1   7.8    2.3  1  SUZ         SUZ domain
        9.7    4.2  14.3         12    3.9  14.3    1.1  1  SSP160      Special lobe-specific silk protein SSP160


Domain annotation for each model (and alignments):
>> HCMV_UL139  Human Cytomegalovirus UL139 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1      0.92   2.4e+03      57      80 ..      31      54 ..      28      67 .. 0.70
   2 ?   12.5   0.0   5.7e-05      0.15      51     101 ..     118     168 ..     110     177 .. 0.89
   3 ?   -2.5   0.0       2.5   6.5e+03      64      73 ..     175     184 ..     171     186 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.92
  HCMV_UL139 57 dakyvaisrdlrslkgeveeaerk 80
                +a+++   ++lr+lk  ++ a+r 
  EFC35569.1 31 KARKQQAAKKLRKLKAMSPVANRN 54
                688888888888888766555444 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 5.7e-05
  HCMV_UL139  51 seidaldakyvaisrdlrslkgeveeaerkeeereryyeakrkemeeflpm 101
                  +i a++a+ + ++  lr++ g+++e+ +k +ere    + ++++e+ +p 
  EFC35569.1 118 HDIMAIKAQMQEMIGVLRTVTGNISELTKKVQEREEESDDDFVNPEAISPE 168
                 578899999999***********************9999999999998875 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.5
  HCMV_UL139  64 srdlrslkge 73 
                  rdlr ++ge
  EFC35569.1 175 YRDLRRVRGE 184
                 699*****99 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   9.4     9e-05      0.23     235     349 ..       3     118 ..       1     186 [. 0.53

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 9e-05
    Macoilin 235 sknnhslnkkdsslklpeleyrekkksakssrsdskkkhehn...esvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnkn 330
                 +k+ ++ ++++s ++lp +e +  ++  k+++++++kk ++    + v ++ ++k+ ++  s++  l    s+  +s+ll ++   ++ss++ sssn++
  EFC35569.1   3 AKKPQDIDSSSSDEDLPAVEVEYPTTPVKARKQQAAKKLRKLkamSPVANRNKRKQSTSVSSSNSALDDGISTVVSSSLLSNSTLLDSSSTAPSSSNNS 101
                 566777777777777777777666555555555555554433233333333333333333333333333334444444444444444444444443333 PP

    Macoilin 331 skkasagsagssnssskkh 349
                 s+++s+    s  sss +h
  EFC35569.1 102 SSSNSGRD--SFASSSSEH 118
                 33333322..222222222 PP

>> LRIF1  Ligand-dependent nuclear receptor-interacting factor 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2  11.1   0.00015      0.39     596     686 ..      30     120 ..       7     131 .. 0.82
   2 ?    3.0   2.0     0.011        29     625     723 ..      98     201 ..      96     213 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00015
       LRIF1 596 kkikleqdlskKRkaktsklvdsaKrrktsnksstssnsetsspssqllssslsksavslqasistdsskssqekksEeellsqesdeket 686
                 +k + +q  +k Rk k ++ v +  +rk+s++ s+s +  +++ s  + ss ls+s ++  +s+  +ss+ s   +s +++ +++s e++ 
  EFC35569.1  30 VKARKQQAAKKLRKLKAMSPVANRNKRKQSTSVSSSNSALDDGISTVVSSSLLSNSTLLDSSSTAPSSSNNSSSSNSGRDSFASSSSEHDI 120
                 456778999999**********************999999999999999999999999988888888888887888888877777776654 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.011
       LRIF1 625 snksstssnsetsspssqllssslsksavslqasistdsskssqekksEeellsqesdeketlssvlvsseedeslfeesftd........daFPvtpp 715
                 sn+ss+s +  +s +ss+    +    a++ q + ++++  +++++ sE  ++ qe +e++ +  v   +  +e  + ++++d         +FPvt +
  EFC35569.1  98 SNNSSSSNSGRDSFASSSS---EHDIMAIKAQMQEMIGVLRTVTGNISELTKKVQEREEESDDDFVNPEAISPEVWLRQTYRDlrrvrgeaRVFPVTYL 193
                 3333333333333333333...33334455566667777778888888888888888888887777777777777777777764444443358****** PP

       LRIF1 716 dldeTirD 723
                 d+d T  +
  EFC35569.1 194 DVDFTNSE 201
                 ***99754 PP

>> Med26_C  Mediator complex subunit 26 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   4.9   0.00084       2.1      40     134 ..      46     139 ..       7     152 .. 0.65

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00084
     Med26_C  40 qrseseakekkaalpspfqqtnwkeLsrneiiqsylsrqsslltssgaqtpgahlfmseylkeeeseskeskklhvlvpessasdlPGvsrevtk 134
                   s   +++k+++ +s  + +   +   + ++ s+l + s+ll ss++  p+++   s     ++s +++s +  +++ +++ +++ Gv r vt 
  EFC35569.1  46 AMSPVANRNKRKQSTSVSSSNSALDDGISTVVSSSLLSNSTLLDSSSTA-PSSSNNSSSSNSGRDSFASSSSEHDIMAIKAQMQEMIGVLRTVTG 139
                 2222222222222333333333333344667899999999999988876.9999999999999999999999********************985 PP

>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   5.4    0.0016       4.2     143     235 ..      38     148 ..      23     163 .. 0.27

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0016
       FAM76 143 ee...krskskkkkskskkskkskekskekkaskkkskkh........kkrss...rlevskleeeklaeekesnetskk...........sldsnssd 216
                 ++   k ++++  ++++k++++ + +s+++  ++                  s    l++s++  ++ +++++sn+ + +           ++++++++
  EFC35569.1  38 AKklrKLKAMSPVANRNKRKQSTSVSSSNSALDDG----IstvvssslL---SnstLLDSSSTAPSSSNNSSSSNSGRDSfassssehdimAIKAQMQE 129
                 11111111111111222111111111111111111....0111222221...12221122221111111111111111111000000111133333333 PP

       FAM76 217 hlvavtqLkeeiaslkkql 235
                  + ++  +  +i +l k++
  EFC35569.1 130 MIGVLRTVTGNISELTKKV 148
                 3333333333333333333 PP

>> SUZ  SUZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   7.8     0.015        39      14      44 ..      97     154 ..      34     154 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.015
         SUZ  14 sssssssrgssgasssesssss...................................ktleEREae 44 
                 ss++sss++s++         s                                   k ++ERE+e
  EFC35569.1  97 SSNNSSSSNSGRD--------SfassssehdimaikaqmqemigvlrtvtgniseltKKVQEREEE 154
                 1111222222222........1344556689*********************************98 PP

>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9  14.3    0.0048        12      97     161 ..      56     118 ..      38     135 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.0048
      SSP160  97 aiqsgsgsasssssssatstssststtssssttssnstt.ttsnstsssnstssgltssasvvsli 161
                   qs s s+s+s+     st  s+s  s+s+   s st+ ++sn++sssns    ++ss+s     
  EFC35569.1  56 RKQSTSVSSSNSALDDGISTVVSSSLLSNSTLLDSSSTApSSSNNSSSSNSGRDSFASSSSE---H 118
                 45788888887778888999999999999999988888723456666677766666666554...3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (247 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1544  (0.0861175); expected 358.6 (0.02)
Passed bias filter:                      676  (0.0377043); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.66u 0.37s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 1389.18
//
Query:       EFC35570.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-11   44.8   0.8      2e-11   44.0   0.8    1.3  1  DEAD            DEAD/DEAH box helicase
  ------ inclusion threshold ------
      0.028   13.8   0.2       0.34   10.3   0.0    2.1  2  TniB            Bacterial TniB protein
      0.038   14.2   0.0       0.11   12.8   0.0    1.7  2  CobA_CobO_BtuR  ATP:corrinoid adenosyltransferase BtuR/CobO/C


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.8   3.3e-15     2e-11       3     154 ..      36     180 ..      27     189 .. 0.82

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 3.3e-15
                 HHHHHHHHHH..TTCEEEEEESTTSSHHHHHHHHHHHHHHHS....TTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHH CS
                 xxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   3 iQaeaiplil..gggdvlvaaeTGsGKTlaflipvlqivyet....kgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskld 95 
                  Q+++ p     ++ +++v+++ G GKT   +i vl++v  +    ++  + + li++P + L +q+ + +  +++yi+        + + +d+   ++
  EFC35570.1  36 QQQQTQPSQQqpSNSSMIVQGRSGEGKTIGLIIKVLKTVDFQkdddDNGVELQGLILVPNEYLGKQITKAMIYLGEYIR--------NATISDN---VN 123
                 4555555555557789********************9995447776667779************************954........3344444...43 PP

                 TTCSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHT..TTHHHHHHHHHHSHHHCT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxx RF
        DEAD  96 ngvdivvgtpgrlddllstgklnlsqvrflVlDEadrlldq..gfsdfinrilnqlpqitc 154
                 ++++i+++tp+ +++    +k+n+s++++l  DE+  +l+     ++ i+ril+q+p+ t+
  EFC35570.1 124 ENPRILITTPSIVIE----KKINVSKLKILACDEMNVMLQIgsPTRRCIKRILQQIPNETE 180
                 56********88886....899******************955578899999999986654 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.027   1.6e+02      33      50 ..      47      64 ..      25     108 .. 0.72
   2 ?   10.3   0.0   5.7e-05      0.34     117     161 ..     143     185 ..     117     200 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.027
        TniB 33 krmpnlllvGdsnnGKtm 50
                   +++++ G+s  GKt 
  EFC35570.1 47 PSNSSMIVQGRSGEGKTI 64
                233678888*******95 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 5.7e-05
        TniB 117 elkvrvLiiDEihnllagsarkqreflnalksLgnelkipivlvG 161
                   k+++L  DE++ +l+  + ++r +  +l+++ ne +i  v  G
  EFC35570.1 143 VSKLKILACDEMNVMLQIGSPTRRCIKRILQQIPNETEIICV--G 185
                 5789********************************998555..4 PP

>> CobA_CobO_BtuR  ATP:corrinoid adenosyltransferase BtuR/CobO/CobP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.32   1.9e+03     109     142 ..      28      62 ..      23      91 .. 0.67
   2 ?   12.8   0.0   1.8e-05      0.11      87     138 ..     136     187 ..      74     203 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.32
  CobA_CobO_BtuR 109 lklglldeeevlellk.kkpeklelvlTGrnapee 142
                     ++ ++l+ ++ ++  + ++p++  +++ Gr+ + +
      EFC35570.1  28 IQQEILNPQQQQTQPSqQQPSNSSMIVQGRSGEGK 62 
                     55566655444433333788888899998876544 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.8e-05
  CobA_CobO_BtuR  87 kakealaseeydlvvlDEinyalklglldeeevlellkkkpeklelvlTGrn 138
                      ++++++ ++++++  DE+n++l++g  +++ + ++l++ p+++e++  G +
      EFC35570.1 136 VIEKKINVSKLKILACDEMNVMLQIGSPTRRCIKRILQQIPNETEIICVGSS 187
                     56777888899************************************99954 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       814  (0.0454013); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1432.22
//
Query:       EFC35571.1  [L=121]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (121 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       573  (0.0319594); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 706.75
//
Query:       EFC35572.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.9e-22   77.8   0.0    1.3e-21   76.8   0.0    1.5  1  Alpha_adaptin_C  Alpha adaptin AP2, C-terminal domain
      2e-12   47.4   0.1      6e-12   45.9   0.0    1.8  2  Alpha_adaptinC2  Adaptin C-terminal domain
     0.0041   17.2   0.0      0.012   15.7   0.0    1.8  2  Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendag
     0.0071   16.4   0.4       0.08   13.0   0.4    2.3  1  B2-adapt-app_C   Beta2-adaptin appendage, C-terminal sub-doma
  ------ inclusion threshold ------
      0.096   12.7   0.3       0.16   12.0   0.3    1.4  1  DUF1930          Domain of unknown function (DUF1930)


Domain annotation for each model (and alignments):
>> Alpha_adaptin_C  Alpha adaptin AP2, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.8   0.0   3.7e-25   1.3e-21       8     112 ..     207     308 ..     199     309 .. 0.87

  Alignments for each domain:
  == domain 1  score: 76.8 bits;  conditional E-value: 3.7e-25
  Alpha_adaptin_C   8 ssedFfkrWkqlggapreaqkifklkaaekeideetvrkvl.eGfrlavlenvdpnpenivgagvlhtsesgkvgcLlrlepNkqakmvrltiR 100
                       +e+Ffk+W+ +g +++e+qkif  +      d +   kvl eGfrla+l+++d np+niv+ag +  +  gkv++Llrle N+ ++ +rlt++
       EFC35572.1 207 GAENFFKQWHAIG-KEQEVQKIFPCTPV--YSDVNACAKVLsEGFRLAILTGID-NPSNIVAAGSFFYDPVGKVNVLLRLEYNAPKQAYRLTVK 296
                      4899********7.778*******6644..4556667777779**********9.89************************************* PP

  Alpha_adaptin_C 101 atkeavpktllk 112
                      a+++++++++ +
       EFC35572.1 297 AQDATIAQQVFN 308
                      ********9875 PP

>> Alpha_adaptinC2  Adaptin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.9   0.0   1.7e-15     6e-12       1      96 [.      90     180 ..      90     185 .. 0.93
   2 ?   -3.0   0.0       2.4   8.6e+03      88      96 ..     288     296 ..     273     309 .. 0.49

  Alignments for each domain:
  == domain 1  score: 45.9 bits;  conditional E-value: 1.7e-15
                      SEEEEEEETTEEEEEEEEETTSTTEEEEEEEEEE-SSS-EEEEEEEEEEBTTCEEEEEEES-S-B-TTCEEEEEEEEEEESCTTS-EEEEEEEE CS
  Alpha_adaptinC2   1 pevvlyekddlqIgfkfekperpgqiritlsftNkssqpisnfsfqaavpkslklqlqppsstvlppnpggqitqvllienpskkplrmrlris 94 
                      +e+v+ e+ +lq+ +k e+  ++ ++r+ l ++Nk+++p+++f+  + vpk+l+ q++     + p   ++q++q + +++++++++   l++ 
       EFC35572.1  90 NEGVAIEDEHLQVKIKTEY--HGCKGRLILLYGNKTTNPLTQFKVHILVPKELEAQISKVPPMISP---KTQVQQYVDLVAKGPFSQLTDLDLY 178
                      5799***************..********************************9999999999999...9*********999999888877776 PP

                      EE CS
  Alpha_adaptinC2  95 yk 96 
                      ++
       EFC35572.1 179 FE 180
                      65 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.4
                      EEEEEEEEE CS
  Alpha_adaptinC2  88 rmrlrisyk 96 
                      +  +r++ k
       EFC35572.1 288 KQAYRLTVK 296
                      333333333 PP

>> Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendage platform
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.9   6.7e+03      79      96 ..      78      95 ..      69     103 .. 0.73
   2 !   15.7   0.0   3.3e-06     0.012       9     114 ..     208     309 ..     198     310 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.9
                     EEEEEEEEEE..SS.EEE CS
  Coatomer_g_Cpla 79 kvlvrarlalssskgvtl 96
                     + +v+ +++l+s++gv++
       EFC35572.1 78 DAAVKHQVLLKSNEGVAI 95
                     456677777777777776 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 3.3e-06
                      -S-HHHHHHHH-STT-EEEEEEE.SS---HHHHHHHHHHHHT-EE-TTTT---SS-SEEEEEEEEEETTS-..EEEEEEEEEE..SS.EEEEEE CS
  Coatomer_g_Cpla   9 vsnFeaaWeeleseaeavetfaL.ssvksleeavdkliellgmqplegsdkvpenassHtLklaGkfvgge..kvlvrarlalssskgvtlklt 99 
                      ++nF ++W ++++e+e+ + f     ++++++ ++ l e + +  l g d +p+n     +  aG f+ +   kv v +rl +++  + + +lt
       EFC35572.1 208 AENFFKQWHAIGKEQEVQKIFPCtPVYSDVNACAKVLSEGFRLAILTGID-NPSN-----IVAAGSFFYDPvgKVNVLLRLEYNA-PKQAYRLT 294
                      349*******************955667777777778899*********9.6655.....7789999997777**********98.5579**** PP

                      EEESSHHHHHHHHHH CS
  Coatomer_g_Cpla 100 vRsedeevaelvlsa 114
                      v+++d+++a+ v + 
       EFC35572.1 295 VKAQDATIAQQVFNY 309
                      ************986 PP

>> B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.4   2.2e-05      0.08       9     108 ..     209     310 ..     207     314 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.2e-05
  B2-adapt-app_C   9 eeFlekWkslpesneqsltlsnnvastspdaleekLqanniftiAkrgvegqqekl....YfsakltngilfLvellintsgksvkvsvKsedpe 99 
                     e+F ++W ++ +++e+++ ++ +++  +++a+ + L++     i   g +++ + +    +f+   + ++ +L+ l +n+++++++++vK++d++
      EFC35572.1 209 ENFFKQWHAIGKEQEVQKIFPCTPVYSDVNACAKVLSEGFRLAIL-TGIDNPSNIVaagsFFYD-PVGKVNVLLRLEYNAPKQAYRLTVKAQDAT 301
                     788888888888888887777765336888888877765433333.233333322222214444.567899********88845*********** PP

  B2-adapt-app_C 100 vaplflqll 108
                     +a+++++++
      EFC35572.1 302 IAQQVFNYI 310
                     ****99876 PP

>> DUF1930  Domain of unknown function (DUF1930)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.3   4.5e-05      0.16       6      63 ..      38      96 ..      33     101 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.5e-05
                SS---TTS-B--TTT--EEETTEEESS--HHHHHH.HTT-BTT-EEEEEETTS-EEEEE CS
     DUF1930  6 vspsLgdnpkAtldavtlvvDGavverPDaElksA.lvHlHiGEkAqvfFksrRvvviE 63
                +++ +g   k + d+     D +vv + D+ l++   vH  +  k qv  ks+  v iE
  EFC35572.1 38 QAANMGKQKKEQRDTTGFNFDDVVVANRDNALEQNeQVHQDAAVKHQVLLKSNEGVAIE 96
                6778899999999*******************875379*******************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       676  (0.0377043); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1825.81
//
Query:       EFC35573.1  [L=315]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-08   34.3   0.0    8.6e-08   31.7   0.0    1.9  2  Aminotran_1_2   Aminotransferase class I and II
    8.7e-05   21.5   0.0    0.00012   21.0   0.0    1.2  1  Aminotran_MocR  Alanine-glyoxylate amino-transferase


Domain annotation for each model (and alignments):
>> Aminotran_1_2  Aminotransferase class I and II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0     0.032   2.9e+02      30      88 ..      40     101 ..      12     107 .. 0.69
   2 !   31.7   0.0   9.6e-12   8.6e-08      93     252 ..     139     306 ..     135     315 .] 0.82

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.032
                    HHHHHTSTTST-BTTHHHHHHHHHHHHHCTCTTCHTTGGEG...EEEESHHHHHHHHHHHHH CS
  Aminotran_1_2  30 galaggtlneygpidglpeleealakflgrseklklkreaa...vvvgsGagaliealifll 88 
                    g  + ++  +y p++glp+l + + k  +  ++l+ + +++   v+++sG++ ++  ++ ++
     EFC35573.1  40 GGKELSDGLQYHPSQGLPSLTQYMRKHQQVTHQLPSDENKQlwdVICTSGSQDGLTKAFEMF 101
                    55666777899999****99999988888666666666654222667777766665555555 PP

  == domain 2  score: 31.7 bits;  conditional E-value: 9.6e-12
                    T-EEEEEESS-T.HHHHHHHHTTSE.EEEEEBEETTTTEE-HHHHHHHHTTHHCTTE..TEEEEE.EESS-TTT--B--HHHHHHHHHHHHHTTEE CS
  Aminotran_1_2  93 gdeilvpdptya.syknilrlsgge.vvryplyseedfhldlealeealkeapegnk..ktkvil.vesphNPtGtvatleeleklldlakkynll 183
                     d+i++ +pty+ s ++ + l+ +   v +        ++  e++eea+ e++++ +   +k+++ + + +NP+G   tle  ++++++ +kyn+l
     EFC35573.1 139 RDAIIIERPTYSgSLSTLFTLNPLMiQVDVD-----AHGIIPEQMEEAIIEFKKQHPnsMIKFLYtIPNGQNPSGCSQTLERKKQIYAISQKYNFL 229
                    5899999999964789999999998555566.....55999********999988887778999735899************************** PP

                    EEEEETTTTCBSSSS.HTHHH...........HGGSTTSTTEEEEEESSSTTSSGGG-EEEEEEEHHHHHHHHHHHHHHTS CS
  Aminotran_1_2 184 lfvDeaYagfvfgsl.davat...........ranveeepnllivgslsKafGlaGeRvGyilgnaavvsqlrklsrpfls 252
                    ++ D+ Y  + + +  d               ++ +++++ +l   s+sK ++  G+R+G+++g  ++++q+    ++ + 
     EFC35573.1 230 ILEDDPYYYLSLYDInD---KemsssiervpsYLSMDTDDRVLRFDSFSKILS-SGIRLGFVTGPVKLINQIVLHIQSSNL 306
                    *********99996642...233567899999999999999*********996.6*********99999987655555444 PP

>> Aminotran_MocR  Alanine-glyoxylate amino-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   1.3e-08   0.00012     125     268 ..     140     292 ..     107     306 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.3e-08
                     -EEEEEES--HHHHHHHHHHT-EEEEEEEETTEE-HHHHHHHHHC......-TTEEEEEE-SSS-TTT-----HHHHHHHHT---SSTT-EEEEE CS
  Aminotran_MocR 125 vkllvtvpGydrhfllleelGielltvdlqddGpdvdaveklvae......dasvkGilavpkysnptGetiseevarrlaalkaaapdfrifad 213
                       +++  p y   +  l +l   ++ vd++  G   +++e+ + e      ++ +k ++++p+  np+G   + e+ +++ a+     +f i+ d
      EFC35573.1 140 DAIIIERPTYSGSLSTLFTLNPLMIQVDVDAHGIIPEQMEEAIIEfkkqhpNSMIKFLYTIPNGQNPSGCSQTLERKKQIYAISQ-KYNFLILED 233
                     4578889999999999999999999999999997666666544322222225679**************************9976.579****** PP

                     -TTSS-BS.SSSS---....-HHHHHHHHT-TTSEEEEEESTTTS-TTSS-EEEEE-HH CS
  Aminotran_MocR 214 dayavhdlvaeedkda....nivalardaGhpdrafvlastskitfaGaGvafvassed 268
                     d y   +l+  +dk+     + v+   +    dr + + s ski  +G  ++fv+   +
      EFC35573.1 234 DPYYYLSLYDINDKEMsssiERVPSYLSMDTDDRVLRFDSFSKILSSGIRLGFVTGPVK 292
                     ********9877777666567799999999***********************987655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       898  (0.0500865); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1997.12
//
Query:       EFC35574.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.14   12.6   0.3       0.96    9.9   0.0    2.4  2  Ntox35    Bacterial toxin 35


Domain annotation for each model (and alignments):
>> Ntox35  Bacterial toxin 35
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   5.4e-05      0.96      26      73 ..       3      50 ..       2      54 .. 0.93
   2 ?   -0.8   0.1      0.12   2.1e+03      21      33 ..     151     163 ..     146     175 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 5.4e-05
      Ntox35 26 kdvkkivvkvmkegkeeaiksakqkvtkikGkeievtaiakdGkvkis 73
                k+v ++v k m +  + + k++k    +i ++ i ++++ k+G+ k +
  EFC35574.1  3 KYVIELVYKSMASFASYPKKGNKYYIPEIANQFISGKCFLKNGEYKFI 50
                79999**************************************99876 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.12
      Ntox35  21 kknnwkdvkkivv 33 
                 +k+ wk+v+++v 
  EFC35574.1 151 GKRVWKNVQNLVP 163
                 5666999998764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       576  (0.0321267); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2240.99
//
Query:       EFC35575.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-10   41.5   3.0      5e-10   39.7   3.0    1.8  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.7   3.0   2.8e-14     5e-10       2     112 ..      46     195 ..      45     198 .. 0.89

  Alignments for each domain:
  == domain 1  score: 39.7 bits;  conditional E-value: 2.8e-14
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHH.....HHHHHHHCSS............ CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklr.....eelekrleke............ 83 
                 ++++l +++  +lF +F e+ f+ e +  w a+e+fk+ k+++++ + +++I n+y+  ++p elni++k +     e++ k l+++            
  EFC35575.1  46 IRKILLNEKWNNLFLKFSEKCFACEDVMMWNAIEKFKTIKSEKQRRELFYNICNTYIRIGAPLELNISRKDFgipeiEKIFKSLKDStinfaskngnvs 144
                 68999***************************************************************98542211155555555559*********** PP

                 .......................STTTTTTHHHHHHHHHHHHHHHHHHHHTS CS
         RGS  84 .......................qpsrklfeeaqeevfellekdsypkFlks 112
                                          ++++f+++q+++   +  d y++F+ s
  EFC35575.1 145 pspklnispkqtstnpqdmsflfAITPEIFDRIQTACEHNML-DNYTRFQAS 195
                 ***************************************995.789999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1033  (0.0576162); expected 358.6 (0.02)
Passed bias filter:                      554  (0.0308997); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1340.45
//
Query:       EFC35576.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        4.7    7.0  12.6        3.9    7.3   0.6    3.0  3  Arg_repressor  Arginine repressor, DNA binding domain


Domain annotation for each model (and alignments):
>> Arg_repressor  Arginine repressor, DNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   1.8    0.0086   1.5e+02      14      32 ..      12      30 ..       6      31 .. 0.87
   2 ?    3.9   0.1    0.0026        46      17      37 ..      33      53 ..      31      57 .. 0.81
   3 ?    7.3   0.6   0.00022       3.9      16      52 ..      67     103 ..      62     110 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.0086
                   HHHS---SHHHHHHHHHTT CS
  Arg_repressor 14 ikeekissQkelvelLkee 32
                   ++e k+ +Q ++ ++L+++
     EFC35576.1 12 VEERKLAEQRQIEQALQKK 30
                   6899************985 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.0026
                   S---SHHHHHHHHHTTT---- CS
  Arg_repressor 17 ekissQkelvelLkeeGidvt 37
                   e+  +Q+el ++L++  + vt
     EFC35576.1 33 EERIKQEELRKELAKVKVPVT 53
                   55568*********9988887 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.00022
                    HS---SHHHHHHHHHTTT----HHHHHHHHHHHT-EE CS
  Arg_repressor  16 eekissQkelvelLkeeGidvtQatvSRdLkelglvk 52 
                    +e++ +Q e  e    + ++ +Q+tvS  ++ l ++ 
     EFC35576.1  67 KEQFLNQSEDKENCSPQQVETNQPTVSKNVQSLDVME 103
                    68899999999999999***********999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3022  (0.168554); expected 358.6 (0.02)
Passed bias filter:                      717  (0.0399911); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 833.65
//
Query:       EFC35577.1  [L=109]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00039   20.3   0.1    0.00072   19.4   0.0    1.5  2  PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase


Domain annotation for each model (and alignments):
>> PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0     4e-08   0.00072     202     248 ..       1      49 [.       1      51 [. 0.84
   2 ?   -2.2   0.0      0.16   2.9e+03      42      58 ..      79      95 ..      58     105 .. 0.51

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 4e-08
                     HHHHT..STTCCHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHCCSS CS
  PI3_PI4_kinase 202 lvlai..dpskdeglfresceealealrrdqnlltrllkkavkdglilw 248
                     +v+ +  ++s+ + +f+e+c++a+++lr+ ++l+++++ +++++++ ++
      EFC35577.1   1 MVEGMggSKSEGYIKFKELCVTAYNILRKSAHLILNMFILMIDANIRDL 49 
                     677784455566669***************************9998665 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.16
                    -----EEESSSSEEEEE CS
  PI3_PI4_kinase 42 lktysviplgrkcgiie 58
                    ++  s+i +++k+++++
      EFC35577.1 79 VYMQSIINESEKALFPQ 95
                    33334444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       543  (0.0302861); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.53
# Mc/sec: 618.15
//
Query:       EFC35578.1  [L=172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-21   74.9   5.1    5.6e-21   74.2   5.1    1.4  1  NuA4      Histone acetyltransferase subunit NuA4
  ------ inclusion threshold ------
      0.043   14.4   0.1      0.043   14.4   0.1    2.4  2  FAM104    Family 104


Domain annotation for each model (and alignments):
>> NuA4  Histone acetyltransferase subunit NuA4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.2   5.1   6.2e-25   5.6e-21       2      76 ..       1      82 [.       1      85 [. 0.86

  Alignments for each domain:
  == domain 1  score: 74.2 bits;  conditional E-value: 6.2e-25
        NuA4  2 LkellkkkrelekelakleeqIydkEteYleetssvGNiikGFdnylk.......ssssssaaerrkrkvtdedriFSlSSv 76
                ++ell+++++le+el+ l+++Iy+ E++Y+++t + GN ikG+d+yl+       +ssss++++ +  k++++driFS SS+
  EFC35578.1  1 MEELLRRRQKLEDELKILQQEIYQSEENYIQDTWHNGNAIKGYDGYLSnkssqrgKSSSSASTSSSTYKIKEKDRIFSDSSL 82
                6799********************************************877776544444444445778************7 PP

>> FAM104  Family 104
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.1   4.8e-06     0.043       3      53 ..       6      76 ..       5      86 .. 0.85
   2 ?    0.2   0.2      0.12   1.1e+03      10      27 ..     153     170 ..     136     172 .] 0.76

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 4.8e-06
      FAM104  3 RrrngneednhllpqpkRskrnsvlqdswdtE...................sssSdsessss.sinspdra 53
                Rrr+  e++ ++l q   +++++ +qd+w +                    sssS s+sss+  i+  dr 
  EFC35578.1  6 RRRQKLEDELKILQQEIYQSEENYIQDTWHNGnaikgydgylsnkssqrgkSSSSASTSSSTyKIKEKDRI 76
                99999*************************999**********9999999777777766666667776664 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.12
      FAM104  10 ednhllpqpkRskrnsvl 27 
                  d+hl+p p+++ rn++ 
  EFC35578.1 153 SDQHLMPPPPKQIRNQFS 170
                 577999999999999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       931  (0.051927); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 1109.39
//
Query:       EFC35579.1  [L=164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.088   13.1   0.0       0.23   11.8   0.0    1.6  1  NUC130_3NT  NUC130/3NT domain


Domain annotation for each model (and alignments):
>> NUC130_3NT  NUC130/3NT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   1.3e-05      0.23       8      25 ..      24      41 ..      22      43 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.3e-05
  NUC130_3NT  8 cYpketkefpqeLselLl 25
                cY++ t ef +++++lL 
  EFC35579.1 24 CYKDVTNEFVEQITDLLG 41
                ****************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       894  (0.0498633); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1064.84
//
Query:       EFC35580.1  [L=416]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.8e-24   83.3   0.9    1.4e-06   28.4   0.0    5.5  6  Kelch_3   Galactose oxidase, central domain
    2.9e-22   78.4   5.3    2.1e-06   27.6   0.0    5.8  6  Kelch_4   Galactose oxidase, central domain
    4.1e-22   77.7   3.6    2.3e-08   34.0   0.0    5.3  6  Kelch_6   Kelch motif
    3.3e-20   71.6  11.7      6e-05   22.9   0.2    5.6  6  Kelch_5   Kelch motif
    5.5e-16   57.9   7.1      9e-06   25.2   0.0    5.4  5  Kelch_1   Kelch motif
      2e-12   46.5   7.7    1.1e-05   25.2   0.0    5.1  6  Kelch_2   Kelch motif
    0.00074   19.3   0.5     0.0016   18.2   0.5    1.5  1  F-box     F-box domain


Domain annotation for each model (and alignments):
>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0         7   1.8e+04      39      46 ..      10      17 ..       7      18 .. 0.81
   2 !   28.4   0.0   5.5e-10   1.4e-06       1      48 [.      21      70 ..      21      71 .. 0.91
   3 !   20.4   0.1   1.8e-07   0.00046       2      47 ..      80     126 ..      79     128 .. 0.86
   4 !   25.4   0.0   4.8e-09   1.2e-05       1      47 [.     129     177 ..     129     179 .. 0.88
   5 ?   -1.1   0.0      0.99   2.5e+03       5      32 ..     186     211 ..     183     237 .. 0.54
   6 ?    2.5   0.0     0.075   1.9e+02       1      17 [.     243     258 ..     243     282 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 7
     Kelch_3 39 paRaghaa 46
                + R+gh++
  EFC35580.1 10 TSRVGHSG 17
                5799**96 PP

  == domain 2  score: 28.4 bits;  conditional E-value: 5.5e-10
     Kelch_3  1 gdrlyifGGlgddgqdrlndvyvydldtntWaei...aslppaRaghaata 48
                +d++y+fGG+  +++  +nd+  +d+++ +W++     + p+aR +h++++
  EFC35580.1 21 NDKVYLFGGFV-NSELLVNDLIQVDVSSQKWENKtihNRGPSARNFHSSCL 70
                799********.889999**************44469999*********96 PP

  == domain 3  score: 20.4 bits;  conditional E-value: 1.8e-07
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWaei....aslppaRaghaat 47 
                 d+++ifGG+    + ++ndv++y +dt +W  +    ++  ++R+g +at
  EFC35580.1  80 DEMVIFGGKS---NGFHNDVWSYRFDTFEWGLLepsgDEIITPRYGQSAT 126
                 78********...*************999986665667778899999988 PP

  == domain 4  score: 25.4 bits;  conditional E-value: 4.8e-09
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWa..eiaslppaRaghaat 47 
                 gd+l++fGG++d++  ++n+++ ++l + +W+  e++    +R++ha++
  EFC35580.1 129 GDYLVVFGGYDDNNSFPSNELFIFNLKSREWKlmELSVELKGRYYHASV 177
                 89******************************55557777799999876 PP

  == domain 5  score: -1.1 bits;  conditional E-value: 0.99
     Kelch_3   5 yifGGlgddgqdrlndvyvydldtntWa 32 
                 yi GG+    +  ++d+  + l+t  ++
  EFC35580.1 186 YILGGKS--ATGLVKDFVKIKLSTLDVK 211
                 7888888..6666666666666655444 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.075
     Kelch_3   1 gdrlyifGGlgddgqdr 17 
                 g rly +GG++ d+ dr
  EFC35580.1 243 GKRLYSIGGCN-DRIDR 258
                 679********.56555 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   1.8e-06    0.0045       2      42 ..      12      51 ..      11      61 .. 0.89
   2 !   17.1   0.1   1.7e-06    0.0042       1      44 [.      62     109 ..      62     114 .. 0.83
   3 !   27.6   0.0   8.3e-10   2.1e-06       2      43 ..     120     161 ..     119     165 .. 0.85
   4 !    6.1   0.0    0.0044        11       1      38 [.     170     207 ..     170     216 .. 0.81
   5 !    8.2   0.0   0.00099       2.5       1      23 [.     229     254 ..     229     272 .. 0.84
   6 ?   -2.1   0.0       1.6   4.2e+03      16      22 ..     314     320 ..     302     322 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.8e-06
     Kelch_4  2 RaghsatsipdgtiylfGGrgedgtllndlylldlstntWr 42
                R+ghs +   ++++ylfGG  +   l+ndl   d+s+ +W+
  EFC35580.1 12 RVGHSGIFH-NDKVYLFGGFVNSELLVNDLIQVDVSSQKWE 51
                9********.79***********9999***999****9994 PP

  == domain 2  score: 17.1 bits;  conditional E-value: 1.7e-06
     Kelch_4   1 pRaghsatsi....pd..gtiylfGGrgedgtllndlylldlstntWrrl 44 
                 +R +hs++ +    +d  ++ ++fGG ++ g ++nd++ + + t +W  l
  EFC35580.1  62 ARNFHSSCLVkrksNDcsDEMVIFGGKSN-G-FHNDVWSYRFDTFEWGLL 109
                 79********866533688**********.5.**********99999555 PP

  == domain 3  score: 27.6 bits;  conditional E-value: 8.3e-10
     Kelch_4   2 RaghsatsipdgtiylfGGrgedg.tllndlylldlstntWrr 43 
                 R g sat   ++++++fGG+ +++  ++n+l++++l++++W+ 
  EFC35580.1 120 RYGQSATIY-GDYLVVFGGYDDNNsFPSNELFIFNLKSREWKL 161
                 555566666.69***********88****************85 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0044
     Kelch_4   1 pRaghsatsi.pdgtiylfGGrgedgtllndlylldlst 38 
                 +R +h+++ +   g+ y+ GG ++ g l++d  ++ lst
  EFC35580.1 170 GRYYHASVLDeETGDWYILGGKSATG-LVKDFVKIKLST 207
                 599*******666**********985.888876666655 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.00099
     Kelch_4   1 pRaghsatsi...pdgtiylfGGrge 23 
                 pR+ghs++     ++ ++y +GG+++
  EFC35580.1 229 PRFGHSLVLEkseNGKRLYSIGGCND 254
                 9*********764447********98 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 1.6
     Kelch_4  16 ylfGGrg 22 
                 ++fGG +
  EFC35580.1 314 FVFGGTY 320
                 6899986 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.7   0.0   7.6e-09   1.9e-05       2      41 ..      12      51 ..      11      53 .. 0.97
   2 !   13.7   0.1   2.4e-05      0.06      14      44 ..      82     110 ..      62     114 .. 0.80
   3 !   34.0   0.0   8.9e-12   2.3e-08       1      41 [.     119     160 ..     119     163 .. 0.95
   4 ?   -0.2   0.0      0.53   1.4e+03      14      23 ..     185     194 ..     171     217 .. 0.60
   5 ?   -0.2   0.0      0.55   1.4e+03       2      20 ..     230     252 ..     229     268 .. 0.68
   6 ?   -2.0   0.0       2.1   5.3e+03      15      23 ..     314     322 ..     314     342 .. 0.72

  Alignments for each domain:
  == domain 1  score: 24.7 bits;  conditional E-value: 7.6e-09
     Kelch_6  2 raghslvsvggkiYifGGytdsspylnkvwvydpetksWe 41
                r+ghs + +++k+Y+fGG ++s+  +n+++  d+++ +We
  EFC35580.1 12 RVGHSGIFHNDKVYLFGGFVNSELLVNDLIQVDVSSQKWE 51
                899************************************8 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2.4e-05
     Kelch_6  14 iYifGGytdsspylnkvwvydpetksWeqlp 44 
                  +ifGG ++   ++n+vw y+++t  W  l+
  EFC35580.1  82 MVIFGGKSN--GFHNDVWSYRFDTFEWGLLE 110
                 68******9..59************997765 PP

  == domain 3  score: 34.0 bits;  conditional E-value: 8.9e-12
     Kelch_6   1 praghslvsvggkiYifGGytds.spylnkvwvydpetksWe 41 
                 pr+g s++++g+++++fGGy+d  s ++n +++++++++ W+
  EFC35580.1 119 PRYGQSATIYGDYLVVFGGYDDNnSFPSNELFIFNLKSREWK 160
                 68999****************99******************7 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.53
     Kelch_6  14 iYifGGytds 23 
                  Yi+GG ++ 
  EFC35580.1 185 WYILGGKSAT 194
                 5999999874 PP

  == domain 5  score: -0.2 bits;  conditional E-value: 0.55
     Kelch_6   2 raghslvs.vg..g.kiYifGGy 20 
                 r ghslv+     g ++Y +GG 
  EFC35580.1 230 RFGHSLVLeKSenGkRLYSIGGC 252
                 56777777422322489999995 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 2.1
     Kelch_6  15 YifGGytds 23 
                 ++fGG ++ 
  EFC35580.1 314 FVFGGTYHK 322
                 699999884 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.1   1.2e-07   0.00031       4      35 ..      11      41 ..      10      47 .. 0.79
   2 !   18.6   0.0   5.2e-07    0.0013       2      42 .]      60     104 ..      59     104 .. 0.86
   3 !   22.9   0.2   2.3e-08     6e-05       4      41 ..     119     156 ..     118     157 .. 0.94
   4 !   11.1   0.1   0.00012      0.31       5      25 ..     171     193 ..     170     200 .. 0.86
   5 ?    2.0   0.0     0.082   2.1e+02       4      22 ..     229     251 ..     228     256 .. 0.74
   6 ?   -3.8   0.1       5.4   1.4e+04      28      37 ..     343     352 ..     342     354 .. 0.76

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 1.2e-07
     Kelch_5  4 pRaghcavtvsekiYvyGGkvgrdgsv.sddvy 35
                +R gh+ +++++k+Y++GG+v  ++++  +d+ 
  EFC35580.1 11 SRVGHSGIFHNDKVYLFGGFV--NSELlVNDLI 41
                899******************..5554158776 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 5.2e-07
     Kelch_5   2 PppRaghcavtv.......sekiYvyGGkvgrdgsvsddvyvLdlpsf 42 
                 P++R  h+++ v       s+++ ++GGk+   +++ +dv+ +   +f
  EFC35580.1  60 PSARNFHSSCLVkrksndcSDEMVIFGGKS---NGFHNDVWSYRFDTF 104
                 99********9977766555**********...9999****8877776 PP

  == domain 3  score: 22.9 bits;  conditional E-value: 2.3e-08
     Kelch_5   4 pRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdlps 41 
                 pR+g +a ++++++ v+GG++ +++ +s+++++++l+s
  EFC35580.1 119 PRYGQSATIYGDYLVVFGGYDDNNSFPSNELFIFNLKS 156
                 89999999*************999999********997 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00012
     Kelch_5   5 Raghcavtvs..ekiYvyGGkvg 25 
                 R++h++v ++  + +Y+ GGk++
  EFC35580.1 171 RYYHASVLDEetGDWYILGGKSA 193
                 9********97888*******96 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.082
     Kelch_5   4 pRaghcavtvs....ekiYvyGG 22 
                 pR+gh+ v  +      +Y +GG
  EFC35580.1 229 PRFGHSLVLEKsengKRLYSIGG 251
                 9*******994233355888888 PP

  == domain 6  score: -3.8 bits;  conditional E-value: 5.4
     Kelch_5  28 gsvsddvyvL 37 
                 +  +dd+++L
  EFC35580.1 343 NVMNDDIFRL 352
                 56789*9988 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   2.8e-07   0.00071       1      41 [.      11      52 ..      11      54 .. 0.95
   2 !    6.3   0.7    0.0028       7.3      12      39 ..      80     106 ..      78     107 .. 0.92
   3 !   25.2   0.0   3.5e-09     9e-06       1      41 [.     119     161 ..     119     163 .. 0.96
   4 !    5.0   0.2    0.0073        19      12      30 ..     244     263 ..     242     264 .. 0.79
   5 ?    1.0   0.0      0.13   3.2e+02      15      33 ..     314     342 ..     314     344 .. 0.93

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 2.8e-07
                BBBSEEEEEETTEEEEEEEBCS.SSBEEEEEEEETTTTEEEE CS
     Kelch_1  1 aragagavvvggkiYviGGsdg.gnalssvevyDpetntWre 41
                +r g++   +++k+Y +GG+ +    ++++   D+ +++W+ 
  EFC35580.1 11 SRVGHSGIFHNDKVYLFGGFVNsELLVNDLIQVDVSSQKWEN 52
                699*************************************96 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0028
                 TEEEEEEEBCSSSBEEEEEEEETTTTEE CS
     Kelch_1  12 gkiYviGGsdggnalssvevyDpetntW 39 
                 +++ ++GG ++  + ++v+ y + t +W
  EFC35580.1  80 DEMVIFGGKSN-GFHNDVWSYRFDTFEW 106
                 57899*****9.*********9999999 PP

  == domain 3  score: 25.2 bits;  conditional E-value: 3.5e-09
                 BBBSEEEEEETTEEEEEEEBCS..SSBEEEEEEEETTTTEEEE CS
     Kelch_1   1 aragagavvvggkiYviGGsdg..gnalssvevyDpetntWre 41 
                 +r+g +a+  g+++ v+GG+d+  + +++ ++++++++ +W  
  EFC35580.1 119 PRYGQSATIYGDYLVVFGGYDDnnSFPSNELFIFNLKSREWKL 161
                 799**************************************86 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.0073
                 TEEEEEEEBCS.SSBEEEEE CS
     Kelch_1  12 gkiYviGGsdg.gnalssve 30 
                  ++Y iGG+++   +l++++
  EFC35580.1 244 KRLYSIGGCNDrIDRLDCIY 263
                 589*******9777777665 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.13
                 EEEEEBCS..........SSBEEEEEEEE CS
     Kelch_1  15 YviGGsdg..........gnalssvevyD 33 
                 +v+GG  +          ++++ ++ev+D
  EFC35580.1 314 FVFGGTYHkievekkkqvNEPTFNIEVFD 342
                 699**999999999999999*******99 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.1   1.9e-05     0.049       2      46 ..      12      54 ..      11      55 .. 0.92
   2 ?    3.5   0.3     0.029        75      14      47 ..      82     111 ..      65     113 .. 0.80
   3 !   25.2   0.0   4.4e-09   1.1e-05       1      45 [.     119     162 ..     119     165 .. 0.96
   4 ?   -2.7   0.0       2.6   6.8e+03      34      45 ..     177     188 ..     175     191 .. 0.78
   5 ?    4.7   0.0     0.013        33       1      24 [.     229     253 ..     229     283 .. 0.81
   6 ?   -2.6   0.0       2.5   6.4e+03      15      43 ..     314     342 ..     314     344 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.9e-05
     Kelch_2  2 rgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWeevt 46
                r+ghs    ++k+y++GG+   n+ l  +d+   d ++++We+ t
  EFC35580.1 12 RVGHSGIFHNDKVYLFGGF--VNSELLVNDLIQVDVSSQKWENKT 54
                8999999************..999999999999999*****9875 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.029
     Kelch_2  14 iyvvGGahtdnpnlsssdvhvldlekhvWeevtp 47 
                 ++++GG     +n +++dv+ +++++ +W ++ p
  EFC35580.1  82 MVIFGGK----SNGFHNDVWSYRFDTFEWGLLEP 111
                 6788888....99*************99966665 PP

  == domain 3  score: 25.2 bits;  conditional E-value: 4.4e-09
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 +r+g+s++  g+ ++v+GG+ +dn++  s+ + +++l++++W+++
  EFC35580.1 119 PRYGQSATIYGDYLVVFGGY-DDNNSFPSNELFIFNLKSREWKLM 162
                 7*******************.*********************998 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 2.6
     Kelch_2  34 vldlekhvWeev 45 
                 vld+e+  W  +
  EFC35580.1 177 VLDEETGDWYIL 188
                 689999999765 PP

  == domain 5  score: 4.7 bits;  conditional E-value: 0.013
     Kelch_2   1 rrgghsssvp....ggkiyvvGGahtdn 24 
                 +r+ghs +      g ++y++GG    n
  EFC35580.1 229 PRFGHSLVLEksenGKRLYSIGGC---N 253
                 688899988888989********9...3 PP

  == domain 6  score: -2.6 bits;  conditional E-value: 2.5
     Kelch_2  15 yvvGGahtdnpnlsssdvhvldlekhvWe 43 
                 +v+GG ++   +++   v+   ++ +v++
  EFC35580.1 314 FVFGGTYHKIEVEKKKQVNEPTFNIEVFD 342
                 79999877777777777766666666655 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.5   6.4e-07    0.0016       7      36 ..     346     375 ..     344     376 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.4e-07
                 -HHHHHHHHHTS-HHHHHHHCTT-HHHHHH CS
       F-box   7 PsevlrhILerLplsdllalrrVSkgwril 36 
                  +++ r +L+++  +dl+ l +VSk++ri+
  EFC35580.1 346 NDDIFRLVLSFMTITDLCKLELVSKKLRIC 375
                 689*************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       558  (0.0311228); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2535.13
//
Query:       EFC35581.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0063   16.4   1.4     0.0063   16.4   1.4    2.7  3  cEGF      Complement Clr-like EGF-like
  ------ inclusion threshold ------
      0.023   14.7   0.0        3.1    8.0   0.0    3.6  3  NHL       NHL repeat
      0.038   14.4  11.3      0.038   14.4  11.3    3.5  3  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   1.4     1e-06    0.0063       6      22 ..     200     216 ..     199     216 .. 0.93
   2 ?   -4.2   2.3       2.9   1.7e+04       3       6 ..     239     242 ..     239     243 .. 0.85
   3 ?   -2.8   0.3       1.1   6.4e+03      15      23 ..     267     274 ..     261     274 .. 0.67

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1e-06
                 -STTEEE.ETTTEEEE- CS
        cEGF   6 CppGYkltpdGrsCtDI 22 
                 C +GY+l++dG++C  I
  EFC35581.1 200 CDSGYQLSSDGKTCDPI 216
                 99************866 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 2.9
                 EEE- CS
        cEGF   3 rCsC 6  
                 +C+C
  EFC35581.1 239 TCQC 242
                 7999 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 1.1
                 TTTEEEE-- CS
        cEGF  15 dGrsCtDID 23 
                 +G +Ct +D
  EFC35581.1 267 QG-TCTAVD 274
                 44.898666 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.43   2.6e+03      15      25 ..      33      43 ..      32      44 .. 0.84
   2 ?    1.8   0.0     0.046   2.8e+02       5      19 ..      75      89 ..      71      93 .. 0.81
   3 ?    8.0   0.0   0.00051       3.1       5      25 ..     170     193 ..     167     196 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.43
                EEEEECCCTEE CS
         NHL 15 iyVaDsenhrv 25
                ++  Ds n+rv
  EFC35581.1 33 FITLDSVNSRV 43
                6789******9 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.046
                EEEEEETTTEEEEEE CS
         NHL  5 hGvavdsnGdiyVaD 19
                +G++v++ G+ y aD
  EFC35581.1 75 SGITVSTAGEYYFAD 89
                8*********99888 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.00051
                 EEEEEETTTEEEEEE...CCCTEE CS
         NHL   5 hGvavdsnGdiyVaD...senhrv 25 
                 +G+ v++ ++iy+++   s n  +
  EFC35581.1 170 SGIYVTNKNEIYITEarsSPNGNI 193
                 7*************9766666655 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.9     0.022   1.3e+02      22      32 .]     199     213 ..     199     213 .. 0.93
   2 ?   14.4  11.3   6.3e-06     0.038       5      32 .]     223     251 ..     217     251 .. 0.89
   3 ?    6.9   4.0    0.0014       8.2       5      15 ..     261     271 ..     256     277 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.022
       EGF_2  22 dCdsgyq....GktC 32 
                 +Cdsgyq    GktC
  EFC35581.1 199 YCDSGYQlssdGKTC 213
                 6******99999999 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 6.3e-06
       EGF_2   5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 d +Cgg  +GtC ++   C+C ++y+G+ C
  EFC35581.1 223 DAACGGptQGTCSAPD-TCQCTTNYFGNEC 251
                 789**********999.9************ PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0014
       EGF_2   5 deiCgghGtCv 15 
                 +++C+++GtC 
  EFC35581.1 261 SNACNNQGTCT 271
                 689*******6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      255  (0.0142228); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.36u 0.25s 00:00:00.61 Elapsed: 00:00:00.40
# Mc/sec: 2180.21
//
Query:       EFC35582.1  [L=426]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.7e-22   77.6  21.4    2.5e-10   39.8   3.7    5.4  5  Pentapeptide    Pentapeptide repeats (8 copies)
    2.8e-16   59.5  36.3    1.3e-10   41.3  10.9    4.8  4  Pentapeptide_4  Pentapeptide repeats (9 copies)
    5.9e-12   45.6  23.2    5.9e-06   26.3   0.8    5.6  5  Pentapeptide_3  Pentapeptide repeats (9 copies)
    0.00033   20.9   0.6     0.0015   18.9   0.0    2.4  2  BTB_2           BTB/POZ domain
  ------ inclusion threshold ------
      0.044   13.4   0.3      0.086   12.4   0.3    1.5  1  F-protein       Negative factor, (F-Protein) or Nef
       0.79    9.9   8.1        6.1    7.0   1.4    2.8  2  TRAF6_Z2        TNF receptor-associated factor 6 zinc finger 
       0.93    9.8  11.1        1.7    8.9  11.1    1.3  1  Vfa1            AAA-ATPase Vps4-associated protein 1
        2.5    6.8  13.8        3.7    6.3  13.8    1.1  1  Mitofilin       Mitochondrial inner membrane protein


Domain annotation for each model (and alignments):
>> Pentapeptide  Pentapeptide repeats (8 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.8   2.6e-07   0.00058      12      40 .]     255     283 ..     253     283 .. 0.93
   2 !   39.8   3.7   1.1e-13   2.5e-10       1      37 [.     284     320 ..     284     321 .. 0.97
   3 !   19.6   0.2   2.3e-07   0.00053       2      35 ..     331     364 ..     328     368 .. 0.55
   4 !    4.9   0.0    0.0091        20       6      18 ..     390     402 ..     382     405 .. 0.66
   5 ?    3.2   0.1     0.031        69       3      13 ..     414     424 ..     408     426 .] 0.45

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 2.6e-07
                   CCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide  12 nLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   +Ls +++sg nL ++n+    L+g+++s+
    EFC35582.1 255 DLSACDFSGMNLESSNFKMLILKGCDFSN 283
                   7999***********************97 PP

  == domain 2  score: 39.8 bits;  conditional E-value: 1.1e-13
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEE CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsgan 37 
                   +nL++An+ ++++ ++nls++ L+++n+s+++Lsga+
    EFC35582.1 284 CNLTNANFIECDMIECNLSNSILNNTNISKSNLSGAK 320
                   9**********************************96 PP

  == domain 3  score: 19.6 bits;  conditional E-value: 2.3e-07
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EECC CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLsg 35 
                   ++s++nLs+  +++  + +  +t++ + g+++++
    EFC35582.1 331 DFSRCNLSNICFKQFKFDNVIFTNSIIDGSKFEN 364
                   4555555555555555555555555555555555 PP

  == domain 4  score: 4.9 bits;  conditional E-value: 0.0091
                   -B-CCSCCEECCC CS
  Pentapeptide   6 AnLsganLsganl 18 
                   ++++g+++++ ++
    EFC35582.1 390 CDFTGTIFEEIDF 402
                   5556666555555 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.031
                   -TT-B-CCSCC CS
  Pentapeptide   3 LsgAnLsganL 13 
                   +s++ + +++L
    EFC35582.1 414 FSNCTFKNSDL 424
                   23333333332 PP

>> Pentapeptide_4  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.2       2.8   6.3e+03       9      27 ..     160     178 ..     159     178 .. 0.81
   2 !   13.9   1.4     2e-05     0.046      31      77 .]     230     281 ..     209     281 .. 0.77
   3 !   41.3  10.9   5.7e-14   1.3e-10       3      75 ..     276     350 ..     274     352 .. 0.94
   4 !   18.5  12.7   7.3e-07    0.0016       2      72 ..     331     402 ..     330     426 .] 0.81

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.8
  Pentapeptide_4   9 nncklsnvnFsearlrdcn 27 
                      ++++s++n   ++++dc+
      EFC35582.1 160 YQTQCSTFNSDPVYFIDCD 178
                     5788888888999999995 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 2e-05
  Pentapeptide_4  31 crl.snvnFdecnlsdvdfaevdlkra...sFsgcnlknvnfsd.klkdidF 77 
                      +l + vn+++ + ++++f   +++++    Fsg+nl+++nf++  lk++dF
      EFC35582.1 230 LNLkNFVNLHKIQKRSLNFKYYNFNDLsacDFSGMNLESSNFKMlILKGCDF 281
                     5553446677777888888887777777779***********9989****98 PP

  == domain 3  score: 41.3 bits;  conditional E-value: 5.7e-14
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdl.krasFsgcnlknvnfsd.klkdi 75 
                     ++ c f nc+l+n+nF e+++++cn++++ l+n+n +++nls +++  ++l  ++ Fs+cnl+n+ f+  k++++
      EFC35582.1 276 LKGCDFSNCNLTNANFIECDMIECNLSNSILNNTNISKSNLSGAKIDVCELiQKVDFSRCNLSNICFKQfKFDNV 350
                     689**********************************************975899************99999876 PP

  == domain 4  score: 18.5 bits;  conditional E-value: 7.3e-07
  Pentapeptide_4   2 eftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsd.kl 72 
                     +f+rc + n +++++ F ++ + ++ + ++++ n +F++c++++    ++ l +  + +c+++++ f++  +
      EFC35582.1 331 DFSRCNLSNICFKQFKFDNVIFTNSIIDGSKFENITFEKCKIKTHFKKNNGLINCKYIACDFTGTIFEEiDF 402
                     789999999999999999998888888888888888888888888888888888888888888888865444 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.2      0.05   1.1e+02      12      29 ..     256     272 ..     252     279 .. 0.60
   2 !   26.3   0.8   2.6e-09   5.9e-06       2      47 ..     277     319 ..     275     320 .. 0.83
   3 !   15.7   3.7   5.4e-06     0.012       1      39 [.     332     368 ..     331     371 .. 0.94
   4 !    6.6   0.1    0.0039       8.8      11      33 ..     381     402 ..     373     403 .. 0.74
   5 !    5.3   0.1    0.0095        21      23      31 ..     414     422 ..     408     426 .] 0.49

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.05
  Pentapeptide_3  12 FrgatFsgaasFsnadFg 29 
                     ++ + Fsg+ + ++++F 
      EFC35582.1 256 LSACDFSGM-NLESSNFK 272
                     556666666.66666664 PP

  == domain 2  score: 26.3 bits;  conditional E-value: 2.6e-09
  Pentapeptide_3   2 sganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsga 47 
                     +g+ Fs++ ++++a+F+ + ++ +++++++ + +++++  +++sga
      EFC35582.1 277 KGCDFSNC-NLTNANFIEC-DMIECNLSNSILNNTNIS-KSNLSGA 319
                     68899999.9999999999.999999999999999988.8888876 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 5.4e-06
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFt 39 
                     Fs++n+s+   F    F++   F+n+ ++++ F++ +F+
      EFC35582.1 332 FSRCNLSNI-CFKQFKFDNV-IFTNSIIDGSKFENITFE 368
                     99*******.**********.5****************8 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0039
  Pentapeptide_3  11 dFrgatFsgaasFsnadFgsadF 33 
                      + ++  + + +F+++ F+++dF
      EFC35582.1 381 GLINCKYIAC-DFTGTIFEEIDF 402
                     5668888888.999999999998 PP

  == domain 5  score: 5.3 bits;  conditional E-value: 0.0095
  Pentapeptide_3  23 FsnadFgsa 31 
                     Fsn++F ++
      EFC35582.1 414 FSNCTFKNS 422
                     333333333 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.2      0.88     2e+03      14      41 ..      32      58 ..      26      92 .. 0.71
   2 !   18.9   0.0   6.6e-07    0.0015       1      73 [.     122     203 ..     122     222 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.88
                HHHHHTSTTSTTTSSGG....GGEETTT CS
       BTB_2 14 kstLsrkpdtlLgkllkteelddydeet 41
                k+tL+rk++  L+k   ++ ++  ++++
  EFC35582.1 32 KETLKRKFNDKLEKEYAKR-TKILENTQ 58
                6788888888887776644.44444333 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 6.6e-07
                 EEEEETTEEEEEEHHHH...HTSTTSTTTSSGG..........GGEETTTTEEEE-S-HHHHHHHHHHHHS..S-B---TTS- CS
       BTB_2   1 vklnVgGtrfetskstL...srkpdtlLgkllkte......elddydeetneyffDRspklFetiLnyyrtg.gkLhrpeeve 73 
                 ++lnV G+++ +s       +r pd l++k+ + +      ++++++++   yf+D +p +F++i+++++ g + ++ +++v+
  EFC35582.1 122 IHLNVRGKIMTVSLGDFihnEREPDNLFKKMFTGQhpcyqtQCSTFNSD-PVYFIDCDPIVFKHIIEWLQYGaIAIELSNDVK 203
                 5688888888887654422246799******999889997447777666.79*******************877777665544 PP

>> F-protein  Negative factor, (F-Protein) or Nef
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.3   3.8e-05     0.086     165     219 ..       6      58 ..       4      59 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.8e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
   F-protein 165 vdveeeeeeaenncLlHpaqlsevdDeegevLvWkfdsklaleykafekypeefk 219
                 v++ + +e++e++c lH a   ++ De +e+L+ kf+ kl  ey  ++k  e+ +
  EFC35582.1   6 VERGQLKEHQEKHCPLHDAY--KQVDELKETLKRKFNDKLEKEYAKRTKILENTQ 58 
                 77888999*********985..67899******************9999887765 PP

>> TRAF6_Z2  TNF receptor-associated factor 6 zinc finger 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.8    0.0066        15       9      27 .]       2      20 ..       1      20 [. 0.88
   2 ?    7.0   1.4    0.0027       6.1      13      24 ..     367     378 ..     365     379 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0066
    TRAF6_Z2  9 CQraFQKnqlkeHilkdCP 27
                C +   + qlkeH  k CP
  EFC35582.1  2 CKGGVERGQLKEHQEKHCP 20
                77777789**********9 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0027
    TRAF6_Z2  13 FQKnqlkeHilk 24 
                 F K+++k+H  k
  EFC35582.1 367 FEKCKIKTHFKK 378
                 99*******876 PP

>> Vfa1  AAA-ATPase Vps4-associated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9  11.1   0.00077       1.7      72     173 ..      21     121 ..       5     124 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00077
        Vfa1  72 iekvkkeyeekqkkkkekekkkkekdkkdkdkkkekekdkkkekek....eeekkkelkkaeeeleekeeprvkkykLhkefyqsRlerkrqaeaaken 166
                 +++  k+++e +++ k+k ++k    +k+ +k  +  +++++e       +++ +k  k++++  e++  + +++++L+++ ++ R+++  +   ++e+
  EFC35582.1  21 LHDAYKQVDELKETLKRKFNDKL---EKEYAKRTKILENTQHE--VvkllQSDYEKLVKQTKQDFEQRRDELTQEFELKEQSFKIRVNEFENSVVSREK 114
                 33333333333333332222222...22222222222222222..123445666666666666666667788889***************999999999 PP

        Vfa1 167 eerlqdp 173
                  e +++p
  EFC35582.1 115 LEASNKP 121
                 9998877 PP

>> Mitofilin  Mitochondrial inner membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  13.8    0.0016       3.7     325     413 ..      26     114 ..      10     133 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0016
   Mitofilin 325 kqkee.lekqeealsarleeerakeerqlrlelereleeireeyeekLrteLerqaeaheehLkdvlveqeieLkrefqqeikekveeEr 413
                 kq +e +e+++++ + +le+e ak+ + l+ ++ + ++ ++++ye+ ++ + ++  e   + L ++ + +e+ +k++ +++ ++ v +E+
  EFC35582.1  26 KQVDElKETLKRKFNDKLEKEYAKRTKILENTQHEVVKLLQSDYEKLVK-QTKQDFEQRRDELTQEFELKEQSFKIRVNEFENSVVSREK 114
                 455566999***********************************98887.99*************************9999999998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (426 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2369  (0.132132); expected 358.6 (0.02)
Passed bias filter:                      639  (0.0356406); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.45
# Mc/sec: 2847.05
//
Query:       EFC35583.1  [L=255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00067   20.0   5.5        0.2   12.1   1.6    2.7  2  CLZ             C-terminal leucine zipper domain of cyclic nu
     0.0033   17.5  14.9       0.01   15.9   3.5    3.0  3  bZIP_1          bZIP transcription factor
  ------ inclusion threshold ------
      0.011   16.3  10.8      0.011   16.3  10.8    1.9  2  APG6_N          Apg6 coiled-coil region
       0.64   10.4  14.3       0.17   12.3  10.7    1.7  2  Fez1            Fez1
        4.7    8.3   5.3        9.2    7.4   0.5    2.5  2  DUF5320         Family of unknown function (DUF5320)
        5.2    7.2  12.5        4.9    7.3   0.7    3.6  3  bZIP_2          Basic region leucine zipper
        5.6    7.0  19.0      0.063   13.3   7.5    2.8  3  CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein C
        5.7    7.0  12.1       0.59   10.2   3.6    2.7  2  DUF1664         Protein of unknown function (DUF1664)
        6.1    6.3  10.3        8.4    5.9  10.0    1.3  1  Exonuc_VII_L    Exonuclease VII, large subunit


Domain annotation for each model (and alignments):
>> CLZ  C-terminal leucine zipper domain of cyclic nucleotide-gated channels
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   1.6   9.9e-05       0.2      15      62 ..     135     182 ..     129     187 .. 0.91
   2 !    9.2   0.1   0.00078       1.6      33      60 ..     194     221 ..     182     234 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.9e-05
         CLZ  15 LDeeaakagaeqkeleekverLessLeaLqtrlarLlaeyessqrkLk 62 
                 L+ e+++ +ae+ + +e +e L+ sL+ L++r+  L +  ++s++k++
  EFC35583.1 135 LEVEVKEVKAENSTCNEEIEILKDSLNKLTKRIDILENRQSQSESKIT 182
                 777888999******************************999999975 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00078
         CLZ  33 verLessLeaLqtrlarLlaeyessqrk 60 
                 +e ++++ ++L+t++  + +e +s+q+k
  EFC35583.1 194 LEGFYNRFNTLETKFTEFTTENQSAQKK 221
                 67789999******************99 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   3.5     5e-06      0.01      26      61 ..     130     165 ..     124     168 .. 0.91
   2 ?   -1.8   0.1       1.8   3.5e+03      12      20 ..     171     179 ..     165     181 .. 0.80
   3 !    8.4   1.0    0.0012       2.3      29      58 ..     202     231 ..     199     238 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 5e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  26 aeieeLerrvkaLekeNksLkseleelkkevekLks 61 
                  + ++Le +vk+ ++eN++  +e+e lk+  +kL +
  EFC35583.1 130 IYLKNLEVEVKEVKAENSTCNEEIEILKDSLNKLTK 165
                 589****************************99976 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.8
                 -HHHHHHHH CS
      bZIP_1  12 kNReaArrs 20 
                  NR ++++s
  EFC35583.1 171 ENRQSQSES 179
                 699999887 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0012
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  29 eeLerrvkaLekeNksLkseleelkkevek 58 
                 + Le+++ ++++eN+s +++ e + ke+ +
  EFC35583.1 202 NTLETKFTEFTTENQSAQKKQEDYLKEILN 231
                 68**************99998887666543 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       1.8   3.7e+03      72      90 ..      59      77 ..      25      90 .. 0.60
   2 ?   16.3  10.8   5.3e-06     0.011      18     129 ..     118     225 ..     102     229 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.8
      APG6_N 72 elekereeleaelaaleee 90
                ++   ++e+e+++++++++
  EFC35583.1 59 DINIRHDEIEKAIEEQWKT 77
                4444455555555555554 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 5.3e-06
      APG6_N  18 leqaekerdaYeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreynelqlellele 116
                 l++   + ++++ +lk+l+ e ke    + e    +ee+e l++  ++l + ++ le+ +++ e+++ ++e+ + a+  e e f +++n l+++ +e+ 
  EFC35583.1 118 LSYKHYKQQSMKIYLKNLEVEVKEV---KAENSTCNEEIEILKDSLNKLTKRIDILENRQSQSESKITNIENNAVAR-VELEGFYNRFNTLETKFTEFT 212
                 5666677889999******996665...479999*************************************998876.56689**************** PP

      APG6_N 117 eeldsleaqyeha 129
                  e +s + + e+ 
  EFC35583.1 213 TENQSAQKKQEDY 225
                 *****99987765 PP

>> Fez1  Fez1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.84   1.7e+03      61      92 ..      60      91 ..      28     130 .. 0.62
   2 ?   12.3  10.7   8.6e-05      0.17      43     152 ..     128     238 ..     118     248 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.84
        Fez1 61 leektlelevcenelqrkkseaellrekvekl 92
                ++ +++e+e+  +e  ++k+ +++ ++k   +
  EFC35583.1 60 INIRHDEIEKAIEEQWKTKAVVTISNDKRLMF 91
                44455555555555555555555555544333 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 8.6e-05
        Fez1  43 lrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelre.elselsleeeeaalesdeakaqrqeaeeleelkreverl 140
                 ++  l++ e e+ke++++ ++ ++e+e +++ l++ +++ ++l++++++ e++++++ + ++++++le   ++ ++ e+k  + ++e+ ++ k++ + l
  EFC35583.1 128 MKIYLKNLEVEVKEVKAENSTCNEEIEILKDSLNKLTKRIDILENRQSQSESKITNIENnAVARVELEGFYNRFNTLETKFTEFTTENQSAQKKQEDYL 226
                 56679999************************************************9872556666666677778888888888888888888888888 PP

        Fez1 141 raeLkeerqkke 152
                 ++ L++ + k+ 
  EFC35583.1 227 KEILNQLQPKNS 238
                 888876554433 PP

>> DUF5320  Family of unknown function (DUF5320)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.5    0.0046       9.2      64      97 ..     135     168 ..     108     177 .. 0.75
   2 ?    2.5   0.4      0.15   3.1e+02      50      86 ..     197     234 ..     191     240 .. 0.59

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0046
     DUF5320  64 aetaeaskeeekelLeeqaeaLeeeleaikkrlk 97 
                  e + ++ ++e++  +e++e+L+++l+++ kr++
  EFC35583.1 135 LEVEVKEVKAENSTCNEEIEILKDSLNKLTKRID 168
                 4566677788888888999999999998888875 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.15
     DUF5320  50 fgrrrraggarla.aaetaeaskeeekelLeeqaeaLe 86 
                 f +r+++  ++++   + +++++++++++L+e  + L+
  EFC35583.1 197 FYNRFNTLETKFTeFTTENQSAQKKQEDYLKEILNQLQ 234
                 44444444444444445566666677777777666665 PP

>> bZIP_2  Basic region leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.7    0.0025       4.9      24      52 ..     129     157 ..     121     159 .. 0.86
   2 ?    4.9   0.9     0.014        27      29      52 ..     155     178 ..     151     180 .. 0.87
   3 ?    3.0   0.7     0.053   1.1e+02      30      54 .]     204     228 ..     200     238 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0025
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_2  24 kakeeeleervkeLeeeNaqLrqkveqLe 52 
                 k++ ++le +vke+++eN++  +++e L+
  EFC35583.1 129 KIYLKNLEVEVKEVKAENSTCNEEIEILK 157
                 667789*************9999998776 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.014
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_2  29 eleervkeLeeeNaqLrqkveqLe 52 
                  l++ +++L+++++ L+++++q e
  EFC35583.1 155 ILKDSLNKLTKRIDILENRQSQSE 178
                 588999**************9976 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.053
                 HHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_2  30 leervkeLeeeNaqLrqkveqLeke 54 
                 le +  e ++eN+  ++k+e + ke
  EFC35583.1 204 LETKFTEFTTENQSAQKKQEDYLKE 228
                 8999999999999999999887665 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.3      0.29   5.8e+02      31      81 ..      58     107 ..      34     108 .. 0.77
   2 ?   13.3   7.5   3.1e-05     0.063      55     131 ..     126     204 ..     119     212 .. 0.81
   3 ?    1.5   0.4      0.14   2.7e+02      52      85 ..     192     225 ..     185     245 .. 0.56

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.29
  CENP-F_leu_zip  31 relemseenqekvileaEtskaevetlkeeieelaeelreleldLvalrse 81 
                     +++++   + ek+i e  + ka v t+ + ++ + ++  + e +++++++e
      EFC35583.1  58 QDINIRHDEIEKAIEEQWKTKA-VVTISNDKRLMFAQIVKSEFKVENCTKE 107
                     5666666777777777766666.4578888888888888888888888877 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 3.1e-05
  CENP-F_leu_zip  55 etlkeeieelaeelreleldLvalrsekeeLekelqkkqervseLeslnsslenlleekEqe..kvqmkeeskaaveeL 131
                     +++k  +++l+ e +e +++ +++ +e e L+ +l+k  +r++ Le+++s+ e+ + + E++   + + e   ++ + L
      EFC35583.1 126 QSMKIYLKNLEVEVKEVKAENSTCNEEIEILKDSLNKLTKRIDILENRQSQSESKITNIENNavARVELEGFYNRFNTL 204
                     5688888999999999999999999***********************************9944333444455555555 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.14
  CENP-F_leu_zip  52 aevetlkeeieelaeelreleldLvalrsekeeL 85 
                      e+e++ +  ++l+++ +e++++ ++ ++ +e+ 
      EFC35583.1 192 VELEGFYNRFNTLETKFTEFTTENQSAQKKQEDY 225
                     5555555566666666666666555554444432 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.6      0.14   2.8e+02      45     103 ..      35      95 ..      29     110 .. 0.72
   2 ?   10.2   3.6    0.0003      0.59      74     124 .]     124     174 ..     100     187 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.14
     DUF1664  45 svskqleqvseslaat..krhLssridrvdkkldeqkeiskeikeevtevredlseigedv 103
                 ++s++l+   + ++++  k  L ++i+   +++++ +e + ++k+ vt  +++   + + v
  EFC35583.1  35 NISQNLKLSRDLIKTVnfKFTLGQDINIRHDEIEKAIEEQWKTKAVVTISNDKRLMFAQIV 95 
                 6777777666666543337788999999999999999999999888876666655555554 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.0003
     DUF1664  74 kldeqkeiskeikeevtevredlseigedvesvkeaveglesklerieekQ 124
                 k++++k   k+++ ev+ev+ + s+ +e++e +k+  ++l ++++ +e++Q
  EFC35583.1 124 KQQSMKIYLKNLEVEVKEVKAENSTCNEEIEILKDSLNKLTKRIDILENRQ 174
                 566677777777778888888888888888888888888888888877776 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  10.0    0.0042       8.4     153     263 ..     121     237 ..      63     242 .. 0.58

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0042
  Exonuc_VII_L 153 errlekaikrlleekkqrleklasrlkspeellerkrqrldeleerleralkkqlkkkrerleelkerl.k.ekleekkerlkklkerle.....ll 242
                   ++  ++++k +l++ + ++++++ + ++ +e +e  +++l++l++r++  l+++ +++++++++++++     +le   +r+++l+++++     + 
    EFC35583.1 121 KHYKQQSMKIYLKNLEVEVKEVKAENSTCNEEIEILKDSLNKLTKRIDI-LENRQSQSESKITNIENNAvArVELEGFYNRFNTLETKFTeftteNQ 216
                   2233344444445555555555555555666666666667777777776.66667777777777776554355555555666666555555544434 PP

  Exonuc_VII_L 243 eekkerleeleeklealsplk 263
                   +++k++ + l+e l++l+p++
    EFC35583.1 217 SAQKKQEDYLKEILNQLQPKN 237
                   555555568899999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2786  (0.155391); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.74u 0.30s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 1498.09
//
Query:       EFC35584.1  [L=157]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (157 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1099  (0.0612973); expected 358.6 (0.02)
Passed bias filter:                      266  (0.0148363); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 986.92
//
Query:       EFC35585.1  [L=455]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (455 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1124  (0.0626917); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 2868.85
//
Query:       EFC35586.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       622  (0.0346924); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 1030.14
//
Query:       EFC35587.1  [L=172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
       0.21   11.3   4.9         15    5.3   0.0    2.3  2  DUF359         Protein of unknown function (DUF359)
       0.46   10.2   5.0        0.2   11.3   1.0    1.9  2  Guanylate_kin  Guanylate kinase


Domain annotation for each model (and alignments):
>> DUF359  Protein of unknown function (DUF359)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0    0.0016        15       9      24 ..      27      42 ..      22      50 .. 0.87
   2 ?    5.1   3.3    0.0019        17      13      72 ..      59     118 ..      51     123 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0016
      DUF359  9 gikPdlaivDgktkRe 24
                ++kP++ i+D k++R+
  EFC35587.1 27 KFKPSIQILDSKIQRK 42
                689************9 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0019
      DUF359  13 dlaivDgktkReeveeeekeeekekekekevievkNpaGtiteelieaikealeseekvl 72 
                 +l+++D+ ++  ++++  +++++++++++++++++N+   i++++i+  ++ + +++++ 
  EFC35587.1  59 KLVFIDEPIRQLPTTTIVNNNNNNNNNNNNITNANNRIDKIEKSIIDLTQQLMLTNNNIN 118
                 67889999998888885555555899999***********************97666654 PP

>> Guanylate_kin  Guanylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.0   2.2e-05       0.2      97     178 ..      34     127 ..      27     130 .. 0.67
   2 ?    0.4   0.2     0.052   4.6e+02      57      79 ..     136     158 ..     133     165 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.2e-05
                    EEE--CHHHHHHH....HTTTTEE..EEEEE......ESSHHHHHHHHTTSSSSHHHHHHHHHHHHHHHHGGGCSSEEEEESSHHHHHHHHHHH CS
  Guanylate_kin  97 iLDvdiqavkqlr....kaelspi..ivFik......ppslkelqrrlksrgkeqeeklakrlaaaekelqeyefdvvivnddleealkklkel 178
                    iLD  iq  ++l+    + elspi   vFi       p++  + ++++++ ++++  + ++r++++ek +      ++++n++++++++ lk++
     EFC35587.1  34 ILDSKIQRKSKLHpylpQLELSPIdkLVFIDepirqlPTTTIVNNNNNNNNNNNNITNANNRIDKIEKSIIDLTQQLMLTNNNINNIVEILKQA 127
                    5566665555544222245666654468885221121334444555566677778889999999999999988899***************975 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.052
                    HHHHHHHHTTTEEEEEE.ETTEEE CS
  Guanylate_kin  57 eemekdiskneflEaae.fsgnly 79 
                    ++m ++++ n++lE ++  ++n++
     EFC35587.1 136 NKMLNNPN-NKMLEDSNnSNNNML 158
                    57777775.689999996777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1669  (0.0930894); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 957.26
//
Query:       EFC35588.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00019   21.6   0.1       0.54   10.6   0.0    2.7  3  Ank_5     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.014   15.9   0.2        6.3    7.7   0.0    3.0  3  Ank_3     Ankyrin repeat
       0.15   11.8   0.0        0.2   11.4   0.0    1.1  1  DUF2857   Protein of unknown function (DUF2857)


Domain annotation for each model (and alignments):
>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.81   4.8e+03      19      24 ..       7      12 ..       6      28 .. 0.68
   2 !    9.4   0.0   0.00023       1.4      16      40 ..      39      61 ..      34      65 .. 0.85
   3 !   10.6   0.0   9.1e-05      0.54       8      41 ..      60      94 ..      59      99 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.81
       Ank_5 19 pLhvAa 24
                pLh A+
  EFC35588.1  7 PLHRAC 12
                789888 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00023
       Ank_5 16 gntpLhvAakygaadvvrlLlarga 40
                g  pL +A+++++  ++++++ +++
  EFC35588.1 39 G-YPLEIAIENRNTIIFEWIF-NNC 61
                4.79*****************.444 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 9.1e-05
       Ank_5  8 dvnrldgggntpLhvAak.ygaadvvrlLlargad 41
                ++n + +   ++L + a  +g+a+++++L++ ga+
  EFC35588.1 60 NCNLSSNVLSNALVTVADiNGSAEWAQNLIKKGAS 94
                5566666666********************99987 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0    0.0081        48       3      23 ..       5      25 ..       3      32 .. 0.79
   2 ?    7.7   0.0    0.0011       6.3       4      26 ..      40      62 ..      39      67 .. 0.87
   3 ?   -1.1   0.0      0.76   4.6e+03      18      29 ..      85      95 ..      70      97 .. 0.72

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0081
       Ank_3  3 etpLhlAarsgnleivkfLle 23
                + pLh+A+    l+ +++  +
  EFC35588.1  5 NGPLHRACVLEYLPAIQWYSN 25
                569*****9998888888766 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0011
       Ank_3  4 tpLhlAarsgnleivkfLlenkg 26
                +pL +A+++ n+ i +++++n++
  EFC35588.1 40 YPLEIAIENRNTIIFEWIFNNCN 62
                69*****************9765 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.76
       Ank_3 18 vkfLlenkgadv 29
                ++ L++ kga +
  EFC35588.1 85 AQNLIK-KGASI 95
                567888.78876 PP

>> DUF2857  Protein of unknown function (DUF2857)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   3.4e-05       0.2      53      94 ..      60     101 ..      47     108 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3.4e-05
     DUF2857  53 kvsvdhealrrlLkqareeeereelidralrlGAsiellakl 94 
                 ++++++++l ++L  +++ + + e  + +++ GAsie+++k+
  EFC35588.1  60 NCNLSSNVLSNALVTVADINGSAEWAQNLIKKGASIEFVQKY 101
                 57889999********************************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       622  (0.0346924); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.54
# Mc/sec: 737.28
//
Query:       EFC35589.1  [L=157]
Description: kinesin, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.1e-43  148.5   0.3    2.4e-43  148.4   0.3    1.0  1  Kinesin      Kinesin motor domain
    3.3e-18   66.0   0.1    4.9e-18   65.5   0.1    1.3  1  Microtub_bd  Microtubule binding
  ------ inclusion threshold ------
       0.47   10.4   4.8        3.1    7.8   0.3    2.5  2  ResIII       Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  148.4   0.3     4e-47   2.4e-43      73     225 ..       1     148 [.       1     156 [. 0.93

  Alignments for each domain:
  == domain 1  score: 148.4 bits;  conditional E-value: 4e-47
                 TSEEEEEEEESTTSSHHHHHTBC..TTTSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEEEEEETTEEEETTSTTTTSTSSEBEEEECTTSCCEEETT CS
     Kinesin  73 GynatifaYGqtgsGKTyTmegk..eeeeeGiipraleelFesikkekeekekefsvkvsylEiYneeiyDLLeskkskkkkklkiredskkgevyvkg 169
                 G+n+t++aYGqtg+GKTyTm g+  +ee  G+ipr+ +e+Fe+i++  e+   e+++ +s+lEiYne+i DL++++    k++l+i++++k+g vyv+ 
  EFC35589.1   1 GFNVTMMAYGQTGAGKTYTMIGSldKEELFGLIPRTAKEMFEIIRSGDEN--IEYKIGCSFLEIYNEKINDLFDKE----KRDLTIIDSPKRG-VYVDR 92 
                 9**********************9888889**************997766..**********************98....456********98.***** PP

                 S--EEESSHHHHHHHHHHHHHHHTSTTSSCTSHHCCSEEEEEEEEEEEETTTTTCE CS
     Kinesin 170 ltevevksaeevlellekgeknrkvaetklneeSSRSHavftitleqknlkeetee 225
                 lte+ v++ +e+l++++ g++nr   +t+ n++  +SH++f i++e+ ++++++++
  EFC35589.1  93 LTEEYVTTEDEMLDIIKIGNNNRLSLSTRTNQDPAQSHSIFIIRVESLSKDSSSNQ 148
                 ***********************************************998877663 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.5   0.1   8.3e-22   4.9e-18      81     148 ..       1      70 [.       1      71 [. 0.95

  Alignments for each domain:
  == domain 1  score: 65.5 bits;  conditional E-value: 8.3e-22
                  T--EEEEEEES...................ST-HCHHHHHHHHHHCCTSCCCCEEEEEEEEEEESS-EEET CS
  Microtub_bd  81 gynvcifaygqTGsGKtyTmeg...eeeeagmipraveeifetiselkekgwkyeielqfveiynekvqDl 148
                  g nv+++aygqTG+GKtyTm g   +ee  g ipr+ +e+fe+i++  +++++y+i ++f+eiynek++Dl
   EFC35589.1   1 GFNVTMMAYGQTGAGKTYTMIGsldKEELFGLIPRTAKEMFEIIRSG-DENIEYKIGCSFLEIYNEKINDL 70 
                  57********************887788899***************9.78********************9 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.3   0.00053       3.1      32      43 ..      11      22 ..       4      30 .. 0.84
   2 ?    4.4   0.6    0.0056        33      85     120 ..     107     146 ..      36     155 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00053
                STTSTHHHHHHH CS
      ResIII 32 aTGtGKTlvaak 43
                 TG+GKT++++ 
  EFC35589.1 11 QTGAGKTYTMIG 22
                7*********75 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0056
                 GEEEESSS-B--...........-SEEEEEHHHHHHTH.. CS
      ResIII  85 igkkvsgdkkka....kekdstnkkilvttiqsldadsee 120
                 i k+ ++++ +     ++  +++ +i+++ ++sl++ds++
  EFC35589.1 107 IIKIGNNNRLSLstrtNQDPAQSHSIFIIRVESLSKDSSS 146
                 2232222222224555556799999***********9943 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (157 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       622  (0.0346924); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 907.22
//
Query:       EFC35590.1  [L=248]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (248 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       989  (0.055162); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1375.38
//
Query:       EFC35591.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.042   14.0   0.3      0.059   13.5   0.3    1.4  1  RFC1      Replication factor RFC1 C terminal domain


Domain annotation for each model (and alignments):
>> RFC1  Replication factor RFC1 C terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.3   3.3e-06     0.059      76     143 ..      52     120 ..      33     159 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.3e-06
                 --HHHHHTTTHHHHHHHHS---------.HHHHHHTTT--SHHHHHHHHHH-X...XXXXXXXXXXXXX CS
        RFC1  76 skselrldylpllkkklvkpLkeegkdg.veevielmdeysLtkedvdslvelslvkgekkkedplkki 143
                 +  el  + l++ +++l+++L +++k g ve+ i++  + ++t e+v+++++ls  ++++ k+++++++
  EFC35591.1  52 TPFELLKYGLEMSFDILYNQLSTHKKIGlVEKLIATYLNQDFTPEHVETIHSLSSLERKDLKANKYTSV 120
                 55567777899999*********98888*************************9995555545555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1294.89
//
Query:       EFC35592.1  [L=289]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (289 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       919  (0.0512577); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1610.69
//
Query:       EFC35593.1  [L=321]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1362  (0.0759663); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1925.56
//
Query:       EFC35594.1  [L=301]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2231  (0.124435); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.29s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 1868.94
//
Query:       EFC35595.1  [L=343]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.5e-05   25.6   2.8       0.16   12.9   0.0    4.2  5  WD40            WD domain, G-beta repeat
  ------ inclusion threshold ------
      0.099   12.7   1.2       0.16   12.0   0.1    2.0  3  Dynein_AAA_lid  Dynein heavy chain AAA lid domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       1.8   1.6e+04      19      29 ..      26      36 ..      21      42 .. 0.61
   2 ?   -3.3   0.0         2   1.8e+04      12      19 ..      66      75 ..      58      79 .. 0.64
   3 ?    1.7   0.0     0.061   5.5e+02      14      38 .]     121     148 ..     110     148 .. 0.74
   4 !    8.0   0.3   0.00064       5.7      12      38 .]     201     233 ..     187     233 .. 0.78
   5 !   12.9   0.0   1.7e-05      0.16       5      38 .]     241     274 ..     237     274 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.8
                ETTSSEEEEEE CS
        WD40 19 spdgawlasGs 29
                s++++ ++s+s
  EFC35595.1 26 SSNNNIITSSS 36
                45555555443 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2
                S..EEEEEEE CS
        WD40 12 s..vtslafs 19
                +  ++sl++s
  EFC35595.1 66 DwmIYSLSWS 75
                2467777665 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.061
                 EEEEEETTSSE....EEEEETTSEEEEEE CS
        WD40  14 tslafspdgaw....lasGsdDgtvriWd 38 
                 t ++f+p+ +     l++ s    +r+W+
  EFC35595.1 121 TKIQFHPSASInnpdLIATS-GDYLRLWN 148
                 56677777777777765567.88899997 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.00064
                 S.....EEEEEEETTSSEEE.EEETTSEEEEEE CS
        WD40  12 s.....vtslafspdgawla.sGsdDgtvriWd 38 
                 s      ts++++ +++ ++ ++s D t+ iWd
  EFC35595.1 201 SefcapLTSFDWCEYNPNMIgTCSIDTTCTIWD 233
                 144455899*99999999998899********9 PP

  == domain 5  score: 12.9 bits;  conditional E-value: 1.7e-05
                 EEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 + l +H + v++++f +++ + + G  Dg++r++d
  EFC35595.1 241 TQLVAHdKEVYDISFKDENIFCTVGA-DGSLRMFD 274
                 45779*888************88888.*****998 PP

>> Dynein_AAA_lid  Dynein heavy chain AAA lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   1.8e-05      0.16      25      95 ..      25      90 ..      10     124 .. 0.79
   2 ?   -2.6   0.1       0.6   5.4e+03      51      69 ..     173     191 ..     155     212 .. 0.62
   3 ?   -2.9   0.0      0.78     7e+03     104     120 ..     242     258 ..     219     259 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.8e-05
  Dynein_AAA_lid 25 pvtdlnlvqslcrllealldefeekeeesadeeleeeeleevleklflfalvWSiGatldedsrekfdefl 95
                    +++++n+++s  + +++ +++  +++   +++ ++++e+ ++   +++++l WS+    de+ r  + +f+
      EFC35595.1 25 SSSNNNIITSSSSSFNSNINNNINSN---NNNRMNQKEIYTYNSDWMIYSLSWSVR--RDEKYRLAIGSFI 90
                    57899999999999999999955554...4699*********************84..4555555555555 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.6
  Dynein_AAA_lid  51 eesadeeleeeeleevlek 69 
                     ++++ ++++++++ + ++k
      EFC35595.1 173 NNNNISSQQQQQTVQTVQK 191
                     2333344444444444444 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 0.78
  Dynein_AAA_lid 104 klppeegtvyDyffdke 120
                     +l  +++ vyD  f+ e
      EFC35595.1 242 QLVAHDKEVYDISFKDE 258
                     34467888999888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2141  (0.119415); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2224.57
//
Query:       EFC35596.1  [L=268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-07   30.2  34.2    1.1e-05   25.5  34.3    3.2  1  Mlf1IP         Myelodysplasia-myeloid leukemia factor 1-inter
  ------ inclusion threshold ------
       0.11   11.6   4.6       0.19   10.8   4.6    1.4  1  Amidinotransf  Amidinotransferase


Domain annotation for each model (and alignments):
>> Mlf1IP  Myelodysplasia-myeloid leukemia factor 1-interacting protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.5  34.3   1.2e-09   1.1e-05      27     171 ..      71     224 ..      10     225 .. 0.72

  Alignments for each domain:
  == domain 1  score: 25.5 bits;  conditional E-value: 1.2e-09
      Mlf1IP  27 rerekrekkaaardpfgamdnm.............msnmrkrmeemarnfeklsndpnahsfssSsvmtyskvgdekpkvyqassstrsapgGiketrr 112
                 +++++++++++  dpf++m+                 +m ++m++ ++ f+++ +d n+h     +   +++  +     + + ss r ++  i + + 
  EFC35596.1  71 TNSNNNDRRRRSEDPFNMMKMSnsffdndpffsnsPFDMMSSMKRSEQLFKRMDEDFNSHFNNINNHSNFDNANSYYSSSFSSISSNRDGS-KISKRKE 168
                 2333333335555566532222333343444222255666777777778888889999888777777777776666666666666665444.4999999 PP

      Mlf1IP 113 avkdsesGlekmaiGhhigdrahvvekkknkktGeeeenqefiNldeseaesFdeewqs 171
                  +kds++G+ek++i +++gd++  +ek+++ k+G+e   +++ N+     ++Fd+ew++
  EFC35596.1 169 IIKDSRTGTEKVSITKQVGDKKSLLEKTRD-KQGKEHVFKKLENVST--DQDFDKEWKQ 224
                 9****************************8.99*****999999975..589*****97 PP

>> Amidinotransf  Amidinotransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   4.6   2.1e-05      0.19      76     152 ..      55     127 ..      21     147 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 2.1e-05
                    TTTITTTGGGS-S-HHHHHHHHHHHHH----EEE---GGGG-TTTTEEEEBSEEEE---SSGGGHHHHHHHHHHHHH CS
  Amidinotransf  76 selgiklgvklseeikiekleladkatsnnsflipplpnlvFtrdwfstigggvvlnpmaapnRrrErllaeliykk 152
                     +++ +++ ++s+  + ++++  ++ +s+ +f + +++n+ F +d+f++ +     + m+++  r E+l++++   +
     EFC35596.1  55 TRSRTTSNSNNSNNSNTNSNNNDRRRRSEDPFNMMKMSNSFFDNDPFFSNSP----FDMMSSMKRSEQLFKRMDEDF 127
                    233333377788888888899999999**********************988....566666666677666665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2361  (0.131686); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.34s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 1600.91
//
Query:       EFC35597.1  [L=318]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      7e-46  156.9   0.1      1e-45  156.3   0.1    1.2  1  AAA-ATPase_like  Predicted AAA-ATPase


Domain annotation for each model (and alignments):
>> AAA-ATPase_like  Predicted AAA-ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  156.3   0.1   5.7e-50     1e-45       1     213 [.      80     316 ..      80     318 .] 0.90

  Alignments for each domain:
  == domain 1  score: 156.3 bits;  conditional E-value: 5.7e-50
  AAA-ATPase_like   1 piGiqdFeeireegylYvDKtelieelveegkyyflsRPRRFGKsLllstLeayfd.....gkkelFkglaiekletkwkeknkypvlkldfsa 89 
                      p+G +dF++ir+   +YvDKt+li  l+e+gk++f++RP R+GKsLlls+L+ y+d     +++elF+gl+i+++++    kn+y+vlkldfs 
       EFC35597.1  80 PYGESDFASIRRSKQFYVDKTNLIPLLEESGKQLFFVRPPRWGKSLLLSMLSSYYDinkkdEFDELFSGLWIGDEQNWTPGKNQYYVLKLDFSI 173
                      89********************************************************9999************77755789************ PP

  AAA-ATPase_like  90 vkleseeeleeslkeklkelekefgkkke........ekslakrlkelieraaektgkkvvvLiDEYDkpilealeee.elaeelre....... 167
                      +   + ++++++l++k++++ + f + +         +++  ++ ++li+ + +++g k++vLiDEYD++ ++++ e+ e ++ + e       
       EFC35597.1 174 QVDGTADDINQRLHTKINTTIEGFLECYGmggevsinQNDSFDTYQKLIQLLVKRKG-KLMVLIDEYDRFANKLIFENpEKYQLIVEgkrgdpt 266
                      ************************999999999*99777778888888888777655.7899***********987665777777777888999 PP

  AAA-ATPase_like 168 ..flrefykvlkk.adeylk..fvfltGvskvtkdsifSglnnlkdislde 213
                         +r+f++ lk+ + + l+  + ++tG+++++  +  Sg+n  ++is d+
       EFC35597.1 267 ssPIRSFFERLKEsSATGLQdfRSIITGITPIALAD-ASGYNVSSNISSDK 316
                      889**********755556534679**********9.7**********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       761  (0.0424452); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 1979.46
//
Query:       EFC35598.1  [L=187]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       418  (0.0233142); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1170.41
//
Query:       EFC35599.1  [L=400]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-31  107.3 197.4    0.00042   20.6  15.1   10.8 10  EGF_2     EGF-like domain
    5.1e-18   65.0 151.7      0.018   15.3   6.7   10.6 10  EGF       EGF-like domain
    4.1e-14   52.6 174.2      0.013   16.1   8.0   12.4 12  hEGF      Human growth factor-like EGF
      0.006   16.8 168.5        2.3    8.6  12.8   10.0  9  EB        EB module


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   1.3     0.004        18      21      30 ..       2      11 ..       1      12 [. 0.89
   2 !   14.8  16.6   6.1e-06     0.027       1      30 [.      19      46 ..      13      49 .. 0.82
   3 !   16.9  14.8   1.3e-06     0.006       6      30 ..      58      81 ..      54      87 .. 0.86
   4 !   19.5  12.6   2.1e-07   0.00092       1      30 [.      89     116 ..      89     117 .. 0.85
   5 !   14.0  16.9   1.1e-05      0.05       6      30 ..     128     151 ..     118     154 .. 0.86
   6 !   14.3  13.0   9.1e-06     0.041       6      28 ..     163     184 ..     159     192 .. 0.82
   7 !   18.6  11.1     4e-07    0.0018       6      30 ..     198     221 ..     194     222 .. 0.84
   8 !   20.6  15.1   9.3e-08   0.00042       1      32 []     229     258 ..     223     258 .. 0.85
   9 !   19.0  10.2     3e-07    0.0013       1      29 [.     263     289 ..     263     293 .. 0.81
  10 !   18.6  15.9   3.9e-07    0.0017       5      32 .]     301     327 ..     293     327 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.004
       EGF_2 21 CdCdsgyqGk 30
                C+C+sg+ G+
  EFC35599.1  2 CECQSGWRGN 11
                ********97 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 6.1e-06
       EGF_2  1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30
                C a  ++C+g+G+C++ +  C+C++g+ G+
  EFC35599.1 19 CDAL-SQCNGNGKCISNN-TCECNDGWKGN 46
                4443.68*******9555.9********97 PP

  == domain 3  score: 16.9 bits;  conditional E-value: 1.3e-06
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGk 30
                ++C+ghG+C++ +  C+C++g+ G+
  EFC35599.1 58 NNCNGHGSCISNN-SCQCNDGWNGN 81
                67*******9666.7********97 PP

  == domain 4  score: 19.5 bits;  conditional E-value: 2.1e-07
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C + +++C+ghG+C++ +  C+C+ g+ G+
  EFC35599.1  89 CDS-SNNCNGHGSCISNN-TCQCFEGWKGN 116
                 766.589*******9555.9*******996 PP

  == domain 5  score: 14.0 bits;  conditional E-value: 1.1e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C+g+G+C++ +  C+C++g+ G+
  EFC35599.1 128 NNCNGNGQCISNN-TCECNDGWRGN 151
                 67*******9555.9********97 PP

  == domain 6  score: 14.3 bits;  conditional E-value: 9.1e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyq 28 
                 ++C+g+G+C++ +  C+C+sg+ 
  EFC35599.1 163 NNCNGNGKCISNN-TCECQSGWN 184
                 68*******9555.9*******6 PP

  == domain 7  score: 18.6 bits;  conditional E-value: 4e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C+g+G+C++ +  C+C+sg+ G+
  EFC35599.1 198 NQCNGNGKCISNN-TCECQSGWRGN 221
                 68*******9555.9********97 PP

  == domain 8  score: 20.6 bits;  conditional E-value: 9.3e-08
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C a  ++C+g+G+C++ +  C+C+ g++G +C
  EFC35599.1 229 CDAL-SQCNGNGKCISNN-TCECKEGWSGIDC 258
                 4443.68*******9555.9************ PP

  == domain 9  score: 19.0 bits;  conditional E-value: 3e-07
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqG 29 
                 Cs+  ++C+g+G+C +  + C+C+sg+  
  EFC35599.1 263 CSSL-NDCNGNGQCLTN-NTCQCESGWKN 289
                 7774.78*******844.48*******75 PP

  == domain 10  score: 18.6 bits;  conditional E-value: 3.9e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+g+G+C++ +  C+C+sg+ G +C
  EFC35599.1 301 MNQCNGNGQCISNN-SCQCNSGWVGLDC 327
                 478*******9666.7***********9 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.4     0.001       4.5      21      31 ..       1      11 [.       1      12 [. 0.92
   2 !    9.7   9.3   0.00023         1       1      32 []      19      47 ..      19      47 .. 0.87
   3 !    9.7  10.5   0.00024       1.1       1      31 [.      54      81 ..      54      82 .. 0.91
   4 !   14.8  10.1   5.9e-06     0.027       1      31 [.      89     116 ..      89     117 .. 0.94
   5 !   10.7  10.9   0.00011      0.51       1      31 [.     124     151 ..     124     152 .. 0.93
   6 !   14.6   9.0   6.7e-06      0.03       1      28 [.     159     183 ..     159     186 .. 0.93
   7 !   14.9   8.8   5.4e-06     0.024       1      31 [.     194     221 ..     194     222 .. 0.89
   8 !   15.3   6.7     4e-06     0.018       1      31 [.     229     256 ..     229     257 .. 0.86
   9 !   12.2   8.7   3.9e-05      0.18       1      30 [.     263     289 ..     263     291 .. 0.86
  10 !   10.8   7.7    0.0001      0.47       1      30 [.     298     324 ..     298     326 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.001
                EEEECTTEEST CS
         EGF 21 tCiCpeGytGk 31
                tC+C++G+ G+
  EFC35599.1  1 TCECQSGWRGN 11
                7********97 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00023
                GCS.TTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF  1 Csp.npCsngGtCvdtgrggytCiCpeGytGkr 32
                C+    C+++G+C+++     tC+C  G++G++
  EFC35599.1 19 CDAlSQCNGNGKCISNN----TCECNDGWKGNN 47
                666456*******9999....**********86 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00024
                GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF  1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31
                C   n+C+++G C+++     +C+C  G+ G+
  EFC35599.1 54 CELlNNCNGHGSCISNN----SCQCNDGWNGN 81
                777688*******9999....*********97 PP

  == domain 4  score: 14.8 bits;  conditional E-value: 5.9e-06
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C++ n+C+++G C+++     tC+C eG++G+
  EFC35599.1  89 CDSsNNCNGHGSCISNN----TCQCFEGWKGN 116
                 889899*******9999....*********97 PP

  == domain 5  score: 10.7 bits;  conditional E-value: 0.00011
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  n+C+++G C+++     tC+C  G+ G+
  EFC35599.1 124 CNLlNNCNGNGQCISNN----TCECNDGWRGN 151
                 999788*******9999....*********97 PP

  == domain 6  score: 14.6 bits;  conditional E-value: 6.7e-06
                 GCS.TTSTTT-EEEEETTTEEEEEECTTE CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGy 28 
                 C++ n+C+++G+C+++     tC+C++G+
  EFC35599.1 159 CDSlNNCNGNGKCISNN----TCECQSGW 183
                 999888*******9999....*******9 PP

  == domain 7  score: 14.9 bits;  conditional E-value: 5.4e-06
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   n C+++G+C+++     tC+C++G+ G+
  EFC35599.1 194 CELmNQCNGNGKCISNN----TCECQSGWRGN 221
                 788456*******9999....*********97 PP

  == domain 8  score: 15.3 bits;  conditional E-value: 4e-06
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+    C+++G+C+++     tC+C+eG++G+
  EFC35599.1 229 CDAlSQCNGNGKCISNN----TCECKEGWSGI 256
                 666456*******9999....*********97 PP

  == domain 9  score: 12.2 bits;  conditional E-value: 3.9e-05
                 GCSTT.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytG 30 
                 Cs+ + C+++G C+++     tC+C +G++ 
  EFC35599.1 263 CSSLNdCNGNGQCLTNN----TCQCESGWKN 289
                 9**555*******7777....*******986 PP

  == domain 10  score: 10.8 bits;  conditional E-value: 0.0001
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytG 30 
                 C   n C+++G C+++     +C+C +G+ G
  EFC35599.1 298 CELmNQCNGNGQCISNN----SCQCNSGWVG 324
                 788456*******9999....********98 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.1   0.6    0.0083        37      15      22 .]       1       8 [.       1       8 [. 0.95
   2 !   12.8   9.8   3.2e-05      0.14       1      22 []      25      43 ..      25      43 .. 0.91
   3 ?   -2.9   0.6       2.9   1.3e+04       3      16 ..      46      54 ..      45      55 .. 0.64
   4 !   12.3  10.1   4.5e-05       0.2       1      22 []      60      78 ..      60      78 .. 0.90
   5 ?   -2.3   1.6       1.8   8.1e+03       1       8 [.      84      90 ..      79      94 .. 0.58
   6 !    8.2   9.2    0.0009         4       1      22 []      95     113 ..      95     113 .. 0.84
   7 !   12.5  10.7   4.1e-05      0.18       1      22 []     130     148 ..     130     148 .. 0.91
   8 !   14.4   9.1     1e-05     0.046       1      22 []     165     183 ..     165     183 .. 0.91
   9 !   14.4   9.1     1e-05     0.046       1      22 []     200     218 ..     200     218 .. 0.91
  10 !   16.1   8.0   2.9e-06     0.013       1      22 []     235     253 ..     235     253 .. 0.91
  11 !   12.5   9.7   4.1e-05      0.18       1      22 []     269     287 ..     269     287 .. 0.93
  12 !   13.2  11.2   2.4e-05      0.11       1      22 []     304     322 ..     304     322 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0083
                -EE--TTX CS
        hEGF 15 kCiCpPGy 22
                +C+C +G+
  EFC35599.1  1 TCECQSGW 8 
                7******* PP

  == domain 2  score: 12.8 bits;  conditional E-value: 3.2e-05
                --TT-EES..-SS.-EE--TTX CS
        hEGF  1 CnngGtCidgvggykCiCpPGy 22
                Cn++G Ci    +++C+C+ G+
  EFC35599.1 25 CNGNGKCI---SNNTCECNDGW 43
                ********...446*******9 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 2.9
                TT-EES..-SS.-E CS
        hEGF  3 ngGtCidgvggykC 16
                n+ +C      ++C
  EFC35599.1 46 NN-QCS----LFTC 54
                55.787....6777 PP

  == domain 4  score: 12.3 bits;  conditional E-value: 4.5e-05
                --TT-EES..-SS.-EE--TTX CS
        hEGF  1 CnngGtCidgvggykCiCpPGy 22
                Cn++G+Ci    ++ C+C+ G+
  EFC35599.1 60 CNGHGSCI---SNNSCQCNDGW 78
                ********...4459******9 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 1.8
                --TT-EES CS
        hEGF  1 CnngGtCi 8 
                C ++ tC+
  EFC35599.1 84 CTQH-TCD 90
                4444.555 PP

  == domain 6  score: 8.2 bits;  conditional E-value: 0.0009
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G+Ci    +++C+C  G+
  EFC35599.1  95 CNGHGSCI---SNNTCQCFEGW 113
                 ********...446****7776 PP

  == domain 7  score: 12.5 bits;  conditional E-value: 4.1e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G+Ci    +++C+C+ G+
  EFC35599.1 130 CNGNGQCI---SNNTCECNDGW 148
                 ********...446*******9 PP

  == domain 8  score: 14.4 bits;  conditional E-value: 1e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G Ci    +++C+C +G+
  EFC35599.1 165 CNGNGKCI---SNNTCECQSGW 183
                 ********...446******** PP

  == domain 9  score: 14.4 bits;  conditional E-value: 1e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G Ci    +++C+C +G+
  EFC35599.1 200 CNGNGKCI---SNNTCECQSGW 218
                 ********...446******** PP

  == domain 10  score: 16.1 bits;  conditional E-value: 2.9e-06
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G Ci    +++C+C+ G+
  EFC35599.1 235 CNGNGKCI---SNNTCECKEGW 253
                 ********...446******** PP

  == domain 11  score: 12.5 bits;  conditional E-value: 4.1e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G+C    ++++C+C +G+
  EFC35599.1 269 CNGNGQCL---TNNTCQCESGW 287
                 ********...666******** PP

  == domain 12  score: 13.2 bits;  conditional E-value: 2.4e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G+Ci    ++ C+C++G+
  EFC35599.1 304 CNGNGQCI---SNNSCQCNSGW 322
                 ********...4459******* PP

>> EB  EB module
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6  19.1     0.019        84      19      49 ..      16      47 ..       2      49 .. 0.80
   2 ?    1.2  13.5       0.1   4.7e+02      21      45 ..      53      78 ..      46      84 .. 0.86
   3 ?    2.6  15.3     0.037   1.7e+02      19      44 ..      86     112 ..      79     119 .. 0.83
   4 !    6.2  11.9    0.0028        13      21      47 ..     123     150 ..     113     155 .. 0.82
   5 !    4.5  13.9    0.0093        42      20      48 ..     157     186 ..     151     190 .. 0.86
   6 !    7.2  13.3    0.0014       6.4      21      47 ..     193     220 ..     185     225 .. 0.84
   7 !    7.8  13.3   0.00089         4      20      44 ..     227     252 ..     220     258 .. 0.89
   8 !    5.2  12.4    0.0058        26      21      49 ..     262     291 ..     258     294 .. 0.86
   9 !    8.6  12.8   0.00051       2.3      20      44 ..     296     321 ..     289     326 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.019
          EB 19 gssCevseqCsggsvC.kagiCvCpegktern 49
                 +sC++ +qC g+ +C ++++C+C++g + +n
  EFC35599.1 16 ATSCDALSQCNGNGKCiSNNTCECNDGWKGNN 47
                568*************7789******987665 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.1
          EB 21 sCevseqCsggsvC.kagiCvCpegk 45
                +Ce  ++C g  +C +++ C+C++g 
  EFC35599.1 53 TCELLNNCNGHGSCiSNNSCQCNDGW 78
                599*******999*7789*****996 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.037
          EB  19 gssCevseqCsggsvC.kagiCvCpeg 44 
                 +++C++s++C g  +C ++++C+C eg
  EFC35599.1  86 QHTCDSSNNCNGHGSCiSNNTCQCFEG 112
                 567*********999*7789****888 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0028
          EB  21 sCevseqCsggsvC.kagiCvCpegkte 47 
                 +C+  ++C g+ +C ++++C+C++g + 
  EFC35599.1 123 ECNLLNNCNGNGQCiSNNTCECNDGWRG 150
                 49************7789******9765 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.0093
          EB  20 ssCevseqCsggsvC.kagiCvCpegkter 48 
                 +sC++ ++C g+ +C ++++C+C++g  ++
  EFC35599.1 157 KSCDSLNNCNGNGKCiSNNTCECQSGWNAK 186
                 58*************7789******97766 PP

  == domain 6  score: 7.2 bits;  conditional E-value: 0.0014
          EB  21 sCevseqCsggsvC.kagiCvCpegkte 47 
                 +Ce  +qC g+ +C ++++C+C++g + 
  EFC35599.1 193 ECELMNQCNGNGKCiSNNTCECQSGWRG 220
                 4*************7789*****99765 PP

  == domain 7  score: 7.8 bits;  conditional E-value: 0.00089
          EB  20 ssCevseqCsggsvC.kagiCvCpeg 44 
                 +sC++ +qC g+ +C ++++C+C+eg
  EFC35599.1 227 TSCDALSQCNGNGKCiSNNTCECKEG 252
                 68*************7789*****98 PP

  == domain 8  score: 5.2 bits;  conditional E-value: 0.0058
          EB  21 sCevseqCsggsvC.kagiCvCpegktern 49 
                 +C++ + C g+ +C  +++C+C +g ++++
  EFC35599.1 262 TCSSLNDCNGNGQClTNNTCQCESGWKNKS 291
                 59999*********8899******987765 PP

  == domain 9  score: 8.6 bits;  conditional E-value: 0.00051
          EB  20 ssCevseqCsggsvC.kagiCvCpeg 44 
                 +sCe  +qC g+ +C +++ C+C++g
  EFC35599.1 296 HSCELMNQCNGNGQCiSNNSCQCNSG 321
                 68*************7789****998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (400 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       847  (0.0472419); expected 358.6 (0.02)
Passed bias filter:                      216  (0.0120475); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.82u 0.32s 00:00:01.13 Elapsed: 00:00:00.54
# Mc/sec: 2228.30
//
Query:       EFC35600.1  [L=183]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.2e-59  198.3   1.2      9e-59  198.0   1.2    1.1  1  DPCD      DPCD protein family


Domain annotation for each model (and alignments):
>> DPCD  DPCD protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  198.0   1.2     5e-63     9e-59       8     164 ..      29     183 .]      24     183 .] 0.96

  Alignments for each domain:
  == domain 1  score: 198.0 bits;  conditional E-value: 5e-63
        DPCD   8 akktsliqdgkrkvhykfedgkemvEEYdvktdellvRkwrkksklgkekeWevevGeeekkanaaseeelikesssnPilvrkdtkksfqwRiRNlpY 106
                   +ts+++dg+rk+h+++e+g emvEE+d++t++ll+Rk+r+ s lg e++W++e+G e k++n    ++li+ s+ nPi++rkdt++ fqwR+RN+ Y
  EFC35600.1  29 PYTTSVVADGRRKFHTTYENGVEMVEEFDLQTNQLLLRKRRTVSILG-EGTWTIEIGGEVKSFNP--IHDLIAPSTVNPIFMRKDTSTLFQWRVRNCFY 124
                 6789****************************************995.677***********999..99****************************** PP

        DPCD 107 pkevysvtvdeeereivvrTtNkKYyKklsipdldrl.klkleqealsfahanntLiis 164
                 + +vy+v++d+e++eiv+ TtNkKYyK++sipd++++ k+kl++e+lsf+ +nntLiis
  EFC35600.1 125 EPNVYKVNIDHEKQEIVISTTNKKYYKRFSIPDMKESpKTKLNDESLSFKLENNTLIIS 183
                 **********************************99879******************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       625  (0.0348597); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.23s 00:00:00.65 Elapsed: 00:00:00.42
# Mc/sec: 1309.44
//
Query:       EFC35601.1  [L=196]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0011   18.6   2.9     0.0017   18.0   2.9    1.3  1  DUF4116       Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.19   11.5   2.1        0.2   11.4   0.5    2.0  2  LpxD          UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyl
       0.22   10.9  37.2       0.25   10.7  37.2    1.0  1  CDC27         DNA polymerase subunit Cdc27
          8    5.0  19.7        9.6    4.7  19.7    1.1  1  SWI-SNF_Ssr4  Fungal domain of unknown function (DUF1750)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   2.9   3.8e-07    0.0017       3      42 ..     156     195 ..     155     196 .] 0.92

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 3.8e-07
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                  i+l+ ++kn ++ + +s+eL+ D++i l+ +k+  ++++
  EFC35601.1 156 KIILKMISKNILCNEIISNELREDRDIKLALIKIGNYPFK 195
                 69*******************************9877775 PP

>> LpxD  UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.3   5.9e+03      55      61 ..      44      50 ..      28      58 .. 0.55
   2 ?   11.4   0.5   4.5e-05       0.2      28      59 ..      98     129 ..      94     146 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.3
                EESS-HH CS
        LpxD 55 ivvenPy 61
                +vve   
  EFC35601.1 44 VVVEKVE 50
                5555544 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 4.5e-05
                 GGCCC---SEEEEEHHHHCCHTTSCS.EESS- CS
        LpxD  28 kqlattkAgavivppdlaealpanaalivven 59 
                 k+ ++tk +av+v ++ ++++++++ ++vve+
  EFC35601.1  98 KKKEETKSSAVVVEKSSKKQKKETKPAVVVEE 129
                 55689*****************9999999986 PP

>> CDC27  DNA polymerase subunit Cdc27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7  37.2   5.6e-05      0.25     106     267 ..       4     156 ..       1     174 [. 0.31

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 5.6e-05
       CDC27 106 nkkndskdslirgaqagpivnkevkraeelgrpplaapaseakektangkkpka.akekaaketssakseskkksaekskdaskettkekaekaas... 200
                 nkkn++k s+i    ag  +++  k+ ++    p+aa  + a e++ +   +ka + +++ +++++ k+  +k+ +ek k+   + +k k     +   
  EFC35601.1   4 NKKNNKKTSAIASEVAGSSSKPSSKKTTTT--APPAA--PVATEVVVEK-VEKAtPTTTTIEKKQTKKATTTKTTQEKKKPDVAADKKRKL----Dqvv 93 
                 445555555555555555444444444443..11111..1111111111.11110111222222222222222222222222222222222....1221 PP

       CDC27 201 skaaslkkkasaksnimksffkakpaekkkkteakeqkveeeseeekekedkeleddsaaeeeeeee 267
                 +++a++k ++++++ ++++ +k++++e k+         e es+ee+e e ++++ +++++++++++
  EFC35601.1  94 EEPAKKKEETKSSAVVVEKSSKKQKKETKP----AVVVEEVESKEEEETEVVVEDXKEEKKKNKQKK 156
                 222222222222222222222222222222....222233344444444444433333322222222 PP

>> SWI-SNF_Ssr4  Fungal domain of unknown function (DUF1750)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7  19.7    0.0021       9.6     517     642 ..      27     154 ..       2     179 .. 0.55

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0021
  SWI-SNF_Ssr4 517 sststpvn.nfptpqeqlsaaqsaaatpasanvaspapaqataqeaqsaesededvemggtee.keketetapdaatesgdwVvvpkggkspseaaa 611
                   s+++t++    ++ ++++   + + atp+++++++ ++++at+ +++++e+++ dv  +  ++  +  +e a+++++  +  Vvv+k  k+++++++
    EFC35601.1  27 SKKTTTTApPAAPVATEVVVEKVEKATPTTTTIEKKQTKKATT-TKTTQEKKKPDVAADKKRKlDQVVEEPAKKKEETKSSAVVVEKSSKKQKKETK 122
                   2222222223344445555556666777666666655555555.55667888889998888885444444455555566677888887776666555 PP

  SWI-SNF_Ssr4 612 kaaaeasaeagaaaaekaakesa.akateaag 642
                    a + ++ e++++++++   e+  ++++++++
    EFC35601.1 123 PAVVVEEVESKEEEETEVVVEDXkEEKKKNKQ 154
                   55554444444444444432222122222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4002  (0.223214); expected 358.6 (0.02)
Passed bias filter:                      620  (0.0345808); expected 358.6 (0.02)
Passed Vit filter:                       153  (0.00853366); expected 17.9 (0.001)
Passed Fwd filter:                        47  (0.00262145); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.97u 0.39s 00:00:01.36 Elapsed: 00:00:00.56
# Mc/sec: 1059.07
//
Query:       EFC35602.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.055   13.4   0.2       0.11   12.4   0.2    1.4  1  TMEM154   TMEM154 protein family


Domain annotation for each model (and alignments):
>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.2   6.3e-06      0.11      66     120 ..       7      61 ..       6      68 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.3e-06
     TMEM154  66 lvllillllvviiliqkkkrkrsKddekseaesdeldsenvkvpifEedvpsvme 120
                 l+ll+l++l+v i iq  +++ +K   ks   ++e+ s++ k++  ++d +  me
  EFC35602.1   7 LILLLLIFLLVGIQIQHTNQQEIKFIRKSSLIHQEISSDQWKQSSIDDDQAYLME 61 
                 68999***************************************99999998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       891  (0.049696); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.39s 00:00:01.04 Elapsed: 00:00:00.57
# Mc/sec: 1666.35
//
Query:       EFC35603.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       740  (0.0412739); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 1449.28
//
Query:       EFC35604.1  [L=277]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.7e-06   28.1   1.9    4.6e-06   26.7   0.4    2.1  2  PP2         Phloem protein 2
     0.0071   16.2   0.1      0.018   14.9   0.1    1.7  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.012   15.5   0.1      0.025   14.5   0.1    1.6  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> PP2  Phloem protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0     0.098   5.8e+02      61     112 ..      61     102 ..      21     134 .. 0.69
   2 !   26.7   0.4   7.7e-10   4.6e-06      13      77 ..     217     276 ..     211     277 .] 0.91

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.098
         PP2  61 YsaylvfkladkaygldekpvevsvkvgseskrkvclvpkkredgWleielg 112
                 +++ ++++   +++g+++++++ ++++ s            ++++W++ +l 
  EFC35604.1  61 FKLEWKIHQDIEHRGWNFVEIDGRLEF-S---------HLGKDEEWMNEKLT 102
                 344444444335777777777777776.3.........23455566666555 PP

  == domain 2  score: 26.7 bits;  conditional E-value: 7.7e-10
         PP2  13 ItwgddpryWkwisepesrfsevaeLkqvcwLeirGkiktkmlspattYsaylvfkladkaygld 77 
                 I+w + ++yWk +++++s f ++ +L +v+w++  +++       +++Y++ l++k++++a+gl 
  EFC35604.1 217 IIWLN-ENYWKTKKSSSSVFGKIIKLSSVWWFDFGATLT----LRRGRYKVSLRYKTTSNACGLA 276
                 66665.59******99*******************9999....899***********99999985 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1     3e-06     0.018      11      38 ..     134     161 ..     132     166 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 3e-06
  F-box-like  11 qIFsyLppsdLlrlalVCrrWrrvaldt 38 
                  I+syL+ +dL  + ++C+  r+++++ 
  EFC35604.1 134 NILSYLHVKDLNTCYQTCKIMRELISSR 161
                 7***********************9776 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.1   4.1e-06     0.025      11      47 ..     132     168 ..     108     169 .. 0.93

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 4.1e-06
                 HHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHHHH CS
       F-box  11 lrhILerLplsdllalrrVSkgwrilidsdrlwcksi 47 
                 + +IL++L  +dl  + +++k +r li s  +  k i
  EFC35604.1 132 WQNILSYLHVKDLNTCYQTCKIMRELISSRDFLIKLI 168
                 78***************************99988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1694.66
//
Query:       EFC35605.1  [L=266]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.018   15.9   1.8        3.9    8.5   0.3    4.0  5  WD40            WD domain, G-beta repeat
      0.024   14.7   1.2      0.044   13.9   0.1    2.0  2  Dynein_AAA_lid  Dynein heavy chain AAA lid domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.3   1.2e+04      19      29 ..      25      35 ..      19      41 .. 0.62
   2 ?   -2.3   0.0       1.1     1e+04      12      19 ..      64      73 ..      55      86 .. 0.65
   3 ?    2.2   0.0     0.043   3.9e+02      14      38 .]     119     146 ..     108     146 .. 0.74
   4 ?    8.5   0.3   0.00043       3.9      12      38 .]     191     223 ..     176     223 .. 0.78
   5 ?    1.0   0.0       0.1     9e+02       5      24 ..     231     251 ..     227     255 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.3
                ETTSSEEEEEE CS
        WD40 19 spdgawlasGs 29
                s++++ ++s+s
  EFC35605.1 25 SSNNNIITSSS 35
                45555555443 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.1
                S..EEEEEEE CS
        WD40 12 s..vtslafs 19
                +  ++sl++s
  EFC35605.1 64 DwmIYSLSWS 73
                2467778554 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.043
                 EEEEEETTSSE....EEEEETTSEEEEEE CS
        WD40  14 tslafspdgaw....lasGsdDgtvriWd 38 
                 t ++f+p+ +     l++ s    +r+W+
  EFC35605.1 119 TKIQFHPSASInnpdLIATS-GDYLRLWN 146
                 56677777777777766567.88899997 PP

  == domain 4  score: 8.5 bits;  conditional E-value: 0.00043
                 S.....EEEEEEETTSSEEE.EEETTSEEEEEE CS
        WD40  12 s.....vtslafspdgawla.sGsdDgtvriWd 38 
                 s      ts++++ +++ ++ ++s D t+ iWd
  EFC35605.1 191 SefcapLTSFDWCEYNPNMIgTCSIDTTCTIWD 223
                 144555899*99999999998899********9 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.1
                 EEEESS.SSEEEEEEETTSSE CS
        WD40   5 rtltGH.ssvtslafspdgaw 24 
                 + l +H + v++++f +++ +
  EFC35605.1 231 TQLVAHdKEVYDISFKDENIF 251
                 45779*888****88777665 PP

>> Dynein_AAA_lid  Dynein heavy chain AAA lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   4.9e-06     0.044      24      96 ..      23      89 ..       9     124 .. 0.79
   2 ?   -0.9   0.1      0.18   1.7e+03      98      98 ..     200     200 ..     148     249 .. 0.55

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 4.9e-06
  Dynein_AAA_lid 24 vpvtdlnlvqslcrllealldefeekeeesadeeleeeeleevleklflfalvWSiGatldedsrekfdeflr 96
                     +++++n+++s  + +++ +++    +++++++ ++++e+ ++   +++++l WS+    de+ r  + +f+ 
      EFC35605.1 23 PSSSNNNIITSSSSSFNSNINN----NNNNNSNRMNQKEIYTYNSDWMIYSLSWSVR--RDEKYRLAIGSFIE 89
                    4678899999999999999999....44446799*********************84..45555555555555 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.18
  Dynein_AAA_lid  98 l 98 
                     +
      EFC35605.1 200 F 200
                     1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2705  (0.150873); expected 358.6 (0.02)
Passed bias filter:                      577  (0.0321825); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 1497.80
//
Query:       EFC35606.1  [L=209]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.9e-18   66.1   0.0    6.9e-18   64.9   0.0    1.6  1  VIT         Vault protein inter-alpha-trypsin domain
    0.00042   20.1   0.0    0.00076   19.3   0.0    1.4  1  VIT_2       Vault protein inter-alpha-trypsin domain
  ------ inclusion threshold ------
       0.13   11.1   6.4       0.16   10.8   6.4    1.1  1  Nucleo_P87  Nucleopolyhedrovirus capsid protein P87
        2.4    8.1  19.1        3.8    7.5  19.1    1.5  1  Mucin       Mucin-like glycoprotein
        4.1    6.9   8.0        5.7    6.4   8.0    1.2  1  PP_M1       Phosphoprotein


Domain annotation for each model (and alignments):
>> VIT  Vault protein inter-alpha-trypsin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.9   0.0   1.9e-21   6.9e-18       1      95 [.     113     209 .]     113     209 .] 0.97

  Alignments for each domain:
  == domain 1  score: 64.9 bits;  conditional E-value: 1.9e-21
         VIT   1 lksvsvevkivdrvarvtvtqtfvNpsseakeakYvfplpegaavsgfemeiggkvikgevkekeearkeyeeavaqgktaglleqe..epdvftvs 95 
                 l s++v+++++  +++v+ t+tf  p+ +++e++ v+p+p+ga+  g++me++gk + ++  eke+a++++e  v++g t++++e+   +++ f+++
  EFC35606.1 113 LVSHHVKCHVTYPIVQVVSTMTFNSPHGKTIEGELVLPMPDGATMMGYAMEVNGKLVDAVPVEKEKAKAVFESEVRAGGTVSIVEKLtqASNCFKTK 209
                 5799**********************************************************************************98779999985 PP

>> VIT_2  Vault protein inter-alpha-trypsin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   2.1e-07   0.00076       8      71 ..     107     170 ..     103     177 .. 0.94

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 2.1e-07
       VIT_2   8 trtplplkaskvsacvlgaslgvtasltYyNdqeqpvegvFvyPldekttvvgfeaeiagRvis 71 
                  +t+lpl++ +v+  v     +v +++t+  ++ + +eg  v P+ ++ t +g+  e++g+++ 
  EFC35606.1 107 ASTLLPLVSHHVKCHVTYPIVQVVSTMTFNSPHGKTIEGELVLPMPDGATMMGYAMEVNGKLVD 170
                 5799*******************************************************99885 PP

>> Nucleo_P87  Nucleopolyhedrovirus capsid protein P87
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   6.4   4.5e-05      0.16     300     395 ..       7     109 ..       3     124 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 4.5e-05
  Nucleo_P87 300 lqspaqtpaperslqsPeqtparrkstkmteeslqsPaqtpawqtpattptretssdteaiksepe.....ktleeklreklpsdlsaqssvpdkk..s 391
                  +s+a   ++  +l++ ++tp ++++t  ++   ++Pa+t + + p++t ++  ss+t+++++ ++      t ++  ++ lp+d + +++v  +k  +
  EFC35606.1   7 KKSAAAVDEEISELEKSSTTPNNTETTSSKQPTATTPAKTEVLDKPKETSQPSISSTTNTTTNATDdkkeiATTTTTSKKDLPTDSFIHVQVTGEKfsD 105
                 45555555666688999999999999999999**********9999999998888887776665431111145566778999*9999988886554114 PP

  Nucleo_P87 392 easa 395
                 +as+
  EFC35606.1 106 KAST 109
                 4444 PP

>> Mucin  Mucin-like glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5  19.1    0.0011       3.8      37      93 ..      21      90 ..       7     136 .. 0.56

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0011
       Mucin 37 eaaegqskltttttttkppttttttt..............tasttittkttkattttttttttttateaPs 93
                e +++ ++ +t tt+ k pt+tt ++               +stt tt+ ++      +ttttt+  + P+
  EFC35606.1 21 EKSSTTPN-NTETTSSKQPTATTPAKtevldkpketsqpsISSTTNTTTNATDDKKEIATTTTTSKKDLPT 90
                44444444.45555555555555555245555555333322222222222222222233333344444444 PP

>> PP_M1  Phosphoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   8.0    0.0016       5.7     119     212 ..      10     106 ..       1     111 [. 0.83

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0016
                 XXXXXXXXXXX..XXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHHHHHHHHHHHHHHHH.HTTT-- CS
       PP_M1 119 sqaveeiisyv..avnfpapvgktsedkstktteekvkkeassapskkeeqsskiklasqessgppaldwsatndeddasveaeiahqia.esfskk 212
                 ++av+e is +  +   p+ ++ ts+++ t tt  k++   ++  + + + ss ++++++ +++  +   ++t  ++d   ++ i  q++ e fs k
  EFC35606.1  10 AAAVDEEISELekSSTTPNNTETTSSKQPTATTPAKTEVLDKPKETSQPSISSTTNTTTNATDDKKEIATTTTTSKKDLPTDSFIHVQVTgEKFSDK 106
                 56777777766225567888888999999**********99999999**********************999999999999*999999965899987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1685  (0.0939818); expected 358.6 (0.02)
Passed bias filter:                      656  (0.0365888); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.38s 00:00:01.02 Elapsed: 00:00:00.55
# Mc/sec: 1147.32
//
Query:       EFC35607.1  [L=167]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.35s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 957.29
//
Query:       EFC35608.1  [L=184]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.065   13.5   1.4       0.19   12.0   0.3    2.1  2  Clr5      Clr5 domain


Domain annotation for each model (and alignments):
>> Clr5  Clr5 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0     0.069   1.2e+03      24      34 ..      42      55 ..      31      67 .. 0.74
   2 ?   12.0   0.3   1.1e-05      0.19       2      48 ..     127     174 ..     126     175 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.069
        Clr5 24 kdvmeiMee...eh 34
                ++vmei+++   +h
  EFC35608.1 42 EQVMEILKDpqqRH 55
                79999997643244 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 1.1e-05
        Clr5   2 eedWeahkatIrrLYleenrsL.kdvmeiMeeehgFkatkrqyktrfk 48 
                 + +W+   + I++ +l +n +L +++ ++M+++++ + +k+ + ++++
  EFC35608.1 127 DSRWDLIAQHITEGFLFKNSKLwSELQKVMKARYKYRSSKAEFDAKLN 174
                 678************988888879*****************9999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (184 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       728  (0.0406046); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1043.83
//
Query:       EFC35609.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1445  (0.0805957); expected 358.6 (0.02)
Passed bias filter:                      859  (0.0479112); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 946.84
//
Query:       EFC35610.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       536  (0.0298957); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 894.17
//
Query:       EFC35611.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.3e-12   46.9   0.6    2.7e-12   46.6   0.6    1.0  1  OST3_OST6  OST3 / OST6 family, transporter family


Domain annotation for each model (and alignments):
>> OST3_OST6  OST3 / OST6 family, transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.6   0.6   1.5e-16   2.7e-12     168     291 ..      23     151 ..       7     152 .. 0.87

  Alignments for each domain:
  == domain 1  score: 46.6 bits;  conditional E-value: 1.5e-16
   OST3_OST6 168 lrrklllkilksktlwavlslliillftsGymfnqIrgvpfva..kdekgg...isyfaggsqnQfgaEtqivallygllallvilLiklvpriknakv 261
                 l+ +++++    k+l+ vl l+ +++  sG ++  I+++p ++  +d +g+   +  +    ++Q+++E++  ++l ++ +l++i+L+ ++   + +++
  EFC35611.1  23 LKLPSIFEKGLPKMLVFVLLLASYFVICSGIVYDMINEPPSIGsrRDADGRvrpVAVLEYRLNAQYVIEGFSAGFLFTIGGLGFISLNWAADPSTTTRS 121
                 555566666667999***************************82245556544456777777**************************99999999*** PP

   OST3_OST6 262 qrvlvivllvlifllfslllslfriKnpgY 291
                 + ++  ++++li+++++ l+   ++K ++Y
  EFC35611.1 122 RYIFLGLGIFLIIIAYNTLIMFLKMKITNY 151
                 **************************9988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 893.38
//
Query:       EFC35612.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.015   14.9   9.0      0.019   14.6   9.0    1.1  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   9.0     1e-06     0.019      49      99 ..     114     163 ..      73     173 .. 0.50

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1e-06
       SR-25  49 e..erskekkkkkrrrssssssssssssssssssssssssddrkkrgkkkdkk 99 
                    er k kk  k+r+sss s   sss s +ss+ +s+ ++  ++  k k++k
  EFC35612.1 114 PvgERAKYKKIGKKRKSSSCS--ISSSNSTTSSCYISNQEHLTRR-RKYKKRK 163
                 233666666655555333333..3333333344444444443333.3333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       881  (0.0491383); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.36u 0.25s 00:00:00.61 Elapsed: 00:00:00.40
# Mc/sec: 1419.24
//
Query:       EFC35613.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.28   12.0   2.6         23    5.8   0.1    2.9  3  FAM24     FAM24 family


Domain annotation for each model (and alignments):
>> FAM24  FAM24 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.1    0.0019        35      19      51 ..      69     104 ..      56     110 .. 0.77
   2 ?    5.8   0.1    0.0013        23      21      50 ..     141     170 ..     127     176 .. 0.83
   3 ?   -2.8   0.0      0.66   1.2e+04      26      44 ..     220     231 ..     197     243 .. 0.50

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0019
       FAM24  19 aekakn...vtqdkviraktittescraLqccdeCs 51 
                  +++++     q++v++ak+  t+s r   ++de +
  EFC35613.1  69 DLNQHQtgeTHQQQVTNAKPSETSSNRRVSIIDETN 104
                 4444445667899****************9999975 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0013
       FAM24  21 kaknvtqdkviraktittescraLqccdeC 50 
                 ++++vt  k+i+ +t++ +s +  q c+ +
  EFC35613.1 141 SSNEVTTFKIIPSETTSQDSSHDQQSCNTS 170
                 4455899*******************9876 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 0.66
       FAM24  26 tqdkviraktittescraL 44 
                 t       ++   +s  +L
  EFC35613.1 220 T-------SAHFHNSSLTL 231
                 2.......22233344444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2088  (0.116459); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 1672.00
//
Query:       EFC35614.1  [L=159]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-09   37.8   0.3    3.3e-09   37.1   0.3    1.4  1  TLD       TLD


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   0.3   1.8e-13   3.3e-09       1     138 [.       6     157 ..       6     158 .. 0.81

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 1.8e-13
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygd.....sesflfsl.spkfkvykstgkn.kaylntssdglgfGgg 92 
                 ll+++++dg++   +++++++k  t+++ik++++++fG++++  + s++++f +      +esf f l ++k  +++ ++++ ++ l+t +++l +   
  EFC35614.1   6 LLFRATRDGFRSADFHRHCDGKLKTVTIIKSDQDDLFGFYATRDLASNCDDFEKGilirdDESFTFRLeNDKCYTFHLEEDKaECPLVTYDSTLLLSY- 103
                 69***************************99999***********777777765555555********989999999855553777777777788765. PP

         TLD  93 qpkfsLwidsslekgtsrhsetfengllsg..........aseerfkikdiEVWgl 138
                   ++ +wi+++ +  +s+++e  e ++l++           se++f +k+iEV+++
  EFC35614.1 104 --AYCFWISDQSDVKYSSSQEDVELHILPQnrlpgkkqryFSEDDFLVKEIEVFHI 157
                 ..89****998888888877555555444445555888888899*********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       389  (0.0216967); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.30s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1045.17
//
Query:       EFC35615.1  [L=185]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.04   13.8   2.3      0.056   13.3   2.3    1.2  1  DUF5089      Domain of unknown function (DUF5089)
      0.094   13.0   3.1       0.15   12.4   3.1    1.3  1  PTPRCAP      Protein tyrosine phosphatase receptor type C-ass
       0.24    9.5   5.6       0.29    9.2   5.6    1.1  1  DNA_pol_phi  DNA polymerase phi
       0.25   10.9   7.6       0.31   10.6   7.6    1.2  1  PPP4R2       PPP4R2
       0.29   10.2   8.2       0.33   10.1   8.2    1.1  1  DUF2457      Protein of unknown function (DUF2457)
        3.7    6.8  10.1        5.4    6.2  10.1    1.2  1  NOA36        NOA36 protein


Domain annotation for each model (and alignments):
>> DUF5089  Domain of unknown function (DUF5089)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   2.3   1.9e-05     0.056      84     136 ..      37      88 ..      31     107 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.9e-05
     DUF5089  84 vdkikkwfkkdkkaeeeveeiknkeeeakeeeedkk.eeeefipedkelvpgee 136
                  ++ikkw+k d++  e+ +e+  ++e++++e +d++  e +++ +d+e v+ e+
  EFC35615.1  37 NSQIKKWIKTDAH--ENTHEFYMEREDSDDEDDDEDyVEDNQVDDDEEKVDNEK 88 
                 579********76..556666555555544444444266667777777777663 PP

>> PTPRCAP  Protein tyrosine phosphatase receptor type C-associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   3.1   4.9e-05      0.15      28      77 ..      38      85 ..      29     104 .. 0.58

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 4.9e-05
     PTPRCAP 28 sppgrWlraraedgeede..eeEdqedeedeeedsedleggeeeaesqeeeq 77
                s   +W +++a +++++   e Ed +de+d e+  ed + + +e    e+ +
  EFC35615.1 38 SQIKKWIKTDAHENTHEFymEREDSDDEDDDEDYVEDNQVDDDE----EKVD 85
                56789*****9666555401445555555555532222222222....2222 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   5.6   9.6e-05      0.29     657     688 ..      57      89 ..      30     112 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 9.6e-05
  DNA_pol_phi 657 eededse.edddeeesdedeededdedvdeide 688
                  +e eds+ eddde+  ++++ d+d+e+vd++++
   EFC35615.1  57 MEREDSDdEDDDEDYVEDNQVDDDEEKVDNEKN 89 
                  222222212222222233333555566665543 PP

>> PPP4R2  PPP4R2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   7.6    0.0001      0.31     250     281 ..      36      88 ..       3      94 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.0001
      PPP4R2 250 e.....................kdddeeddeedtdyveeeeddesedddeeee 281
                                       + +d++d+++d+dyve+++ d++e++ ++e+
  EFC35615.1  36 YnsqikkwiktdahenthefymEREDSDDEDDDEDYVEDNQVDDDEEKVDNEK 88 
                 044444444444444444555556899999********977666666655554 PP

>> DUF2457  Protein of unknown function (DUF2457)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   8.2   0.00011      0.33      47      87 ..      45      86 ..       6     111 .. 0.51

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00011
     DUF2457 47 eeEaeeeeeeeeddeedeedddddd.ddedddedddeedede 87
                  +a+e+ +e   + ed++d+ddd+   ed++ dddee  d+
  EFC35615.1 45 KTDAHENTHEFYMEREDSDDEDDDEdYVEDNQVDDDEEKVDN 86
                344444433332222222222222202222222222222222 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2  10.1    0.0018       5.4     268     300 ..      55      87 ..      27      93 .. 0.46

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0018
       NOA36 268 deddegdedddddddeedddeeeddedeeeeee 300
                    +++d+dd+ddd++  +d++ dd++e+ ++e
  EFC35615.1  55 FYMEREDSDDEDDDEDYVEDNQVDDDEEKVDNE 87 
                 223334444444444444444433333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1015  (0.0566122); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1232.59
//
Query:       EFC35616.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.15   12.1   0.2       0.59   10.2   0.1    1.8  2  DUF3568   Protein of unknown function (DUF3568)


Domain annotation for each model (and alignments):
>> DUF3568  Protein of unknown function (DUF3568)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.1   3.3e-05      0.59       2      49 ..       7      48 ..       4      65 .. 0.75
   2 ?   -0.4   0.0     0.062   1.1e+03     102     121 ..     107     125 ..     100     128 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 3.3e-05
     DUF3568  2 lllllllsislillasCaalvagaaagagtvayvnGelkaeyeanlkk 49
                l++ll++s++l +++ C  +v +++      +y++G+l  ++e+n+++
  EFC35616.1  7 LFILLAVSLLLFASVTCENIVYSTT------TYMDGTLVPSFETNVET 48
                4556666666677777888888877......8*****99999999875 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.062
     DUF3568 102 vsIrvGslGDeqaSrrllda 121
                 ++ r   +GD++ S  + ++
  EFC35616.1 107 LQCRTSVIGDSKNSLLI-SQ 125
                 66788899**9999655.44 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       717  (0.0399911); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.51
# Mc/sec: 767.31
//
Query:       EFC35617.1  [L=328]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0058   16.5   0.1       0.01   15.7   0.1    1.4  1  Propeptide_C1   Peptidase family C1 propeptide
  ------ inclusion threshold ------
        0.1   12.8   0.2       0.45   10.7   0.1    2.1  2  Condensin2nSMC  Condensin II non structural maintenance of ch
        0.2   11.8   2.1        1.3    9.2   0.1    2.7  3  Lipin_mid       Lipin/Ned1/Smp2 multi-domain protein middle d


Domain annotation for each model (and alignments):
>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.1   1.7e-06      0.01       4      32 ..     180     210 ..     178     212 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.7e-06
                    HHHHHHHHCT-SEEE---..-SSBSHHHHHC CS
  Propeptide_C1   4 efIdyiNsknttWkAgrN..Fdnttlsyikg 32 
                    ++I+ iNs+n +W+A+    F++ tl+++k+
     EFC35617.1 180 SLIQRINSNNFGWRAKAHkvFAGKTLGDLKK 210
                    79**************9999*9779999998 PP

>> Condensin2nSMC  Condensin II non structural maintenance of chromosomes subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.54   3.2e+03     119     142 ..     178     201 ..     176     203 .. 0.89
   2 ?   10.7   0.1   7.5e-05      0.45      86     112 ..     215     240 ..     207     250 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.54
  Condensin2nSMC 119 epilwrsLkvanskvRanAaella 142
                     +p l + ++++n   Ra+A +++a
      EFC35617.1 178 DPSLIQRINSNNFGWRAKAHKVFA 201
                     688899999***********9997 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 7.5e-05
  Condensin2nSMC  86 krkklakklrkvLsafhskkkekevee 112
                     + ++++ ++++vL+++hs+kkekev+ 
      EFC35617.1 215 D-SSVMDRFKDVLDKIHSQKKEKEVDS 240
                     3.88999******************96 PP

>> Lipin_mid  Lipin/Ned1/Smp2 multi-domain protein middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.1   0.00022       1.3      26      84 ..       8      70 ..       2      79 .. 0.86
   2 ?    0.9   0.0     0.087   5.2e+02      39      60 ..     176     197 ..     167     204 .. 0.82
   3 ?   -2.2   0.3      0.78   4.7e+03      84      84 ..     244     244 ..     218     270 .. 0.50

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00022
   Lipin_mid 26 lvtyedfcknpslledpnLvvrin..dkYynwavaaplilsllvFqkplpeeavekllke..k 84
                +++  ++++n  lle+++L+++i   +k +n    + ++ sl  F +++ +e+ ekl k+  +
  EFC35617.1  8 KIKQAYIENNIPLLENDELLIEIPrlTKILNKPFQVQIVGSLFYFDRKIAKEKTEKLFKNfpR 70
                556667788889***********9999******************************998542 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.087
   Lipin_mid  39 ledpnLvvrindkYynwavaap 60 
                  +dp+L+ rin+  + w++ a 
  EFC35617.1 176 ANDPSLIQRINSNNFGWRAKAH 197
                 689********99999998665 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.78
   Lipin_mid  84 k 84 
                 +
  EFC35617.1 244 S 244
                 0 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2021  (0.112722); expected 358.6 (0.02)
Passed bias filter:                      672  (0.0374812); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.47u 0.25s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 2318.61
//
Query:       EFC35618.1  [L=177]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       658  (0.0367003); expected 358.6 (0.02)
Passed bias filter:                      192  (0.0107089); expected 358.6 (0.02)
Passed Vit filter:                         6  (0.000334653); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 1166.00
//
Query:       EFC35619.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.9e-26   91.3   8.2    7.1e-26   91.0   8.2    1.1  1  Form_Nir_trans  Formate/nitrite transporter
  ------ inclusion threshold ------
      0.076   11.9   2.9      0.086   11.7   2.9    1.0  1  PelG            Putative exopolysaccharide Exporter (EPS-E)


Domain annotation for each model (and alignments):
>> Form_Nir_trans  Formate/nitrite transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.0   8.2   7.9e-30   7.1e-26     159     236 .]       1      82 [.       1      82 [. 0.97

  Alignments for each domain:
  == domain 1  score: 91.0 bits;  conditional E-value: 7.9e-30
                     HHHHHHCC-SSHHHHHHHHHHHHHHHHHCT---HHHHHHHHHHHHHH....SHHHHHHHCHHHHHHHHHHHHHCCHHHHHHH CS
  Form_Nir_trans 159 lavwlalaakdvigkilaiflpifafvasgfeHsvanmfliplglll....tvadfilknlipvtlGNivGGallvgllyly 236
                     +a++ alaa+++ gkil+i++pi++fv + feHsvan ++iplg+l+    t++dfi+knlip+tlGNi+GGa+++g+l++y
      EFC35619.1   1 MATYNALAATTLEGKILGIWFPIMVFVSCSFEHSVANAYFIPLGMLYganvTMYDFIVKNLIPATLGNIIGGAFIIGCLFYY 82 
                     688999***************************************9999999***************************997 PP

>> PelG  Putative exopolysaccharide Exporter (EPS-E)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   2.9   9.6e-06     0.086     133     232 ..       6     106 ..       1     116 [. 0.90

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 9.6e-06
        PelG 133 kllalalfvvlsliWiamiflsalkdykaiilsFligylvsvllalllrkl.legleglllgfalGllvllvlllvlilreFpesesisfdflkylkky 230
                 +l+a++l   ++ iW  +++  ++    +++ +++i +++   + + + ++ +++l+ + lg ++G + ++ +l++++  + ++ ++  f+f++++ ky
  EFC35619.1   6 ALAATTLEGKILGIWFPIMVFVSCSFEHSVANAYFIPLGMLYGANVTMYDFiVKNLIPATLGNIIGGAFIIGCLFYYVNDYRNRHNRFIFNFIEKIWKY 104
                 56666777788999*99999999*************************999999***********************999999************9999 PP

        PelG 231 ps 232
                 ++
  EFC35619.1 105 LK 106
                 76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1068  (0.0595683); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.53
# Mc/sec: 918.80
//
Query:       EFC35620.1  [L=181]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.029   13.9   4.9      0.035   13.6   4.9    1.2  1  Exo5           Exonuclease V - a 5' deoxyribonuclease


Domain annotation for each model (and alignments):
>> Exo5  Exonuclease V - a 5' deoxyribonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   4.9   1.9e-06     0.035     191     290 ..       5     112 ..       1     162 [. 0.66

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.9e-06
        Exo5 191 iQlmlYrrlLselaadkldiesvferydldpdepfsdaflaqigkledevfeeldseaeseseee........eeveassssqdslsellkyntLssll 281
                 + + +Y+++ +++++++   + +f  y++dp+++fs +   q ++++++++ + +++++++s+++        ++++  +++++s ++ + +n++++ +
  EFC35620.1   5 YSIEYYNNINNNITNNNTANQPIFTFYNFDPNNNFSSNNNIQSSNINNNININNNNTTSTTSNNNnfinfspsKNSNFVKEAKKSCKKRTFNNNINTNI 103
                 5678999999999999999****************9988888888886555555444444444444677766533333333444444444445555544 PP

        Exo5 282 kllkkelal 290
                 +   ++ + 
  EFC35620.1 104 TSSSSQSTS 112
                 443333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2343  (0.130682); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.35s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1017.65
//
Query:       EFC35621.1  [L=334]
Description: type-B carboxylesterase/lipase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-31  110.0   2.2    5.2e-20   71.8   1.7    2.0  2  COesterase  Carboxylesterase family


Domain annotation for each model (and alignments):
>> COesterase  Carboxylesterase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   0.0   1.1e-13   1.9e-09     206     327 ..       3     125 ..       1     136 [. 0.87
   2 !   71.8   1.7   2.9e-24   5.2e-20     378     511 ..     160     318 ..     150     319 .. 0.90

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 1.1e-13
                 GGGTTSBSEEEEES--TTSTTTSBSHHHHHHHHHHHHTTS-CSSHHHHHHHHHCS-HHHHHHCCGG.....SSSSSSTTC-SSS-B--SSSSSS-HHHH CS
  COesterase 206 plsrglfkraIlqSGsalspwaiqkkarkrakklakkvgckassskelveclrsksaeelldaqek.....aleasssklvsfaPvvdgdflpekPeel 299
                 + s+glf++aI qS     p+   k+  +  +++ ++ +c      ++++cl++ + + +++   +      +  + + ++++ Pv+d   l e+P+++
  EFC35621.1   3 KKSEGLFNQAIFQSNPLSLPFRDLKSLNNLGERFIQDSKC------KTLSCLKQLNFNLIVKYSDEssnhlNILHPIISFMPWTPVIDHIELFEQPLDA 95 
                 6799**********87777777777788888999999999......7899***********999888998878889999**********88888***** PP

                 HHCGC..CSEEEEEEETTTTHHHHCCHSTT CS
  COesterase 300 lkseg..kvplliGvnkdegllflaylldk 327
                 +k+ +  k+p+++G+ ++e+ +f++  l++
  EFC35621.1  96 FKNGNyfKIPIMMGTCSEEAIMFIYLALSS 125
                 ***77******************9876655 PP

  == domain 2  score: 71.8 bits;  conditional E-value: 2.9e-24
                 HHHHHHHHHHHHTHHHHHHHHHHHHHTT-S..EEEEEEE--STTSSS......T.TTGSSBTTTTHHHHTTGGGTSGCSS-HHHHHHHHHHHHHHHHHH CS
  COesterase 378 rkallelltdvlfkapvlrtaklhasrgsp..vYlYsfdyrnssskk......p.kwmgvvhgdeleyvfglpllekeeftkedeklsrkmmtywtnFa 467
                 r +++ l td++f+ap++++++++ +++s+  +++Y+f++  s s++      p     v+hg+el+ +f+ + + +   ++++e ls++m++ywtnFa
  EFC35621.1 160 RIQFSILGTDYIFTAPTRNALENIYQHQSNipIFFYEFNHTLSFSEQvfkeryPfCIGHVCHGSELPILFHSSQYVNLYLNEQEELLSHQMIQYWTNFA 258
                 55677788***************996666555**********99999888777656678**************9999966667999************* PP

                 HHSSTTS................TTSS----B.TTTBEEEEESSSSSEEEESTTHHHHHH CS
  COesterase 468 ktgnPnk................eeeekWpkytkeeekylkinlkpkrvkkklkeeevaf 511
                 ++gnPn                    + W+++t+++   ++++++++++ ++l+++++++
  EFC35621.1 259 YSGNPNYkskdnsksndstrndsIDLPYWSAFTTSNVLNMEFQTPKTSMVQGLRKQKLDM 318
                 ********************999999*****************************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1891.29
//
Query:       EFC35622.1  [L=963]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-07   30.9  15.0    2.2e-07   30.9  15.0    2.6  2  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
        6.7    7.0   7.8        8.8    6.6   0.2    3.7  3  HALZ      Homeobox associated leucine zipper


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.2     0.054   4.9e+02      20      27 ..     170     177 ..     153     189 .. 0.76
   2 !   30.9  15.0   2.4e-11   2.2e-07       2      38 ..     833     867 ..     832     869 .. 0.93

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.054
                 -HHHHHCT CS
     Zn_clus  20 CsnCkkln 27 
                 CsnC+++ 
  EFC35622.1 170 CSNCEQNF 177
                 9***9875 PP

  == domain 2  score: 30.9 bits;  conditional E-value: 2.4e-11
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysessk 38 
                 +Cd+C k K++C+ +kP C +Ck+ln+eC+ ys ++k
  EFC35622.1 833 SCDSCVKLKIRCNSGKP-CIHCKRLNKECV-YSTKQK 867
                 9****************.************.877764 PP

>> HALZ  Homeobox associated leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.3     0.041   3.6e+02      25      38 ..     106     119 ..     104     123 .. 0.85
   2 ?    0.8   0.2     0.067     6e+02      30      42 ..     520     532 ..     519     533 .. 0.87
   3 ?    6.6   0.2   0.00098       8.8       9      25 ..     738     754 ..     737     759 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.041
        HALZ  25 kkenekLkaelqeL 38 
                 +ke ekLkae+++ 
  EFC35622.1 106 EKETEKLKAEIRKI 119
                 599*******9986 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.067
        HALZ  30 kLkaelqeLkekl 42 
                 +L+a++q+Lk++ 
  EFC35622.1 520 SLEAKIQKLKGMS 532
                 8*********986 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.00098
        HALZ   9 vLKasYdaLksdydsLk 25 
                 +LK+++++Lks  +sL 
  EFC35622.1 738 TLKQDFEKLKSCSESLS 754
                 79*********999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (963 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1541  (0.0859501); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.84u 0.32s 00:00:01.15 Elapsed: 00:00:00.53
# Mc/sec: 5488.40
//
Query:       EFC35623.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.01   16.4   2.4       0.01   16.4   2.4    2.0  2  PRESAN        Plasmodium RESA N-terminal
       0.17   12.0   3.6        1.5    8.9   1.0    2.6  2  Nucleoporin2  Nucleoporin autopeptidase


Domain annotation for each model (and alignments):
>> PRESAN  Plasmodium RESA N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.3      0.16   1.4e+03      60      90 ..      33      67 ..      17      71 .. 0.58
   2 ?   16.4   2.4   1.1e-06      0.01      35     119 ..      76     158 ..      69     162 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.16
                HHHHHHH....HHHHHHHHHHHHHHHHHHHHHHHH CS
      PRESAN 60 eeykkkl....wkeckneitkelkklekeynknfy 90
                ++ + k+     k++k+ +  ++ +le+++ ++  
  EFC35623.1 33 KDTSSKMktqaGKKFKKPLWAKMLELEQKHIDKVR 67
                33333333333666666666666666666666555 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 1.1e-06
                 HHHHHHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS-SEEEHHHHHHHHHHHHHHHHHHHH CS
      PRESAN  35 kkkyknmikkLsnyleelakkynipeeykkklwkeckneitkelkklekeynknfynllkkkklsidefkefinsyrklwkkllk 119
                  ++y+++i++L+n+l+ + +   i  +y++k+wke+  + t  lk+   + n +f n l+ ++++   f+++i ++  + k++  
  EFC35623.1  76 DDEYNRIIEDLKNKLSITTDTEFI--DYAQKKWKEFCIDATTVLKDNLTFGNVKFGNGLNLGNMNYAIFDKIITRNYQCAKDVVY 158
                 679*******************99..7999**********************************************999998876 PP

>> Nucleoporin2  Nucleoporin autopeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   1.0   0.00017       1.5      74     135 ..      39     106 ..       8     112 .. 0.65
   2 ?    3.0   0.1     0.011     1e+02      33      71 ..     122     161 ..     110     171 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00017
                   .---TTSTT-S-EEE...EESS---B-TTT--B---TT-HHHHHHHHHHHH-....SSSEEEEEETTTT CS
  Nucleoporin2  74 ekppvGegLNkpaei...tLenvwpkdkatkeeikdkskarvkkhieklkkv....egteFvsydpetg 135
                    k + G+++ kp      +Le+    dk ++ +    s+ +++++ie lk++    ++teF++y ++++
    EFC35623.1  39 MKTQAGKKFKKPLWAkmlELEQKHI-DKVRSFKAIPISDDEYNRIIEDLKNKlsitTDTEFIDYAQKKW 106
                   4677788887775440003444333.344444444456677888888888888888********98875 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.011
                   TTEEEEESS-B--GGG-HHHHBTTTEEEETTEE..EESSSC CS
  Nucleoporin2  33 gvGsveFlepvdlssldldeiagkivklekkev..tVYpde 71 
                    +G+v+F + ++l +++   i++ki++ + + +  +VY+++
    EFC35623.1 122 TFGNVKFGNGLNLGNMNY-AIFDKIITRNYQCAkdVVYDEQ 161
                   68**************96.4668888766654422577766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       873  (0.0486921); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1548.50
//
Query:       EFC35624.1  [L=587]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00061   19.2   1.5      0.003   17.0   0.2    2.5  2  Pkinase   Protein kinase domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1     0.018   3.3e+02     193     249 ..     171     232 ..     164     240 .. 0.68
   2 !   17.0   0.2   1.6e-07     0.003     233     264 .]     434     484 ..     315     484 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.018
                 SS-STTTSSHHHHHHHHHHTHHHHHHHCT......SHH...HHHTTS-HHHHHHHHHHT-SSG CS
     Pkinase 193 gkppfsgekgkekvekeldqlekilkilg......etkeklpeaseiseeakdllkkllkkdp 249
                 g+  +  ++ k ++++el++++ki+++ +      ++k+kl+  + i   +kdl+++ll+ ++
  EFC35624.1 171 GEIQMG-SELKGEKWEELENVKKIFMVSElleislNSKKKLRVSNVIYLMIKDLITQLLTTKK 232
                 555444.44555677777777777777776656666677777777778889999999998765 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 1.6e-07
                 S...................-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 233 i...................seeakdllkkllkkdpkkRltaeellqhpyl 264
                                     + ++ ++++++l++dpkkRlt e++l hp+l
  EFC35624.1 434 SysfskkhlklsklmrlrsnDYQFVSFITSILEYDPKKRLTPEKALFHPFL 484
                 03333334444455555555899**************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (587 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1429  (0.0797033); expected 358.6 (0.02)
Passed bias filter:                      437  (0.0243739); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.23s 00:00:00.80 Elapsed: 00:00:00.45
# Mc/sec: 3917.80
//
Query:       EFC35625.1  [L=165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       532  (0.0296726); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1010.08
//
Query:       EFC35626.1  [L=276]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.2e-17   62.3  19.1    0.00024   20.9   0.3    6.8  7  LRR_6      Leucine Rich repeat
    5.8e-08   32.9  28.4    1.4e-05   25.3   1.7    5.4  6  LRR_4      Leucine Rich repeats (2 copies)
    6.2e-07   29.1  26.1    2.9e-05   23.8   6.2    4.3  4  LRR_8      Leucine rich repeat
  ------ inclusion threshold ------
      0.023   15.2  19.8       0.89   10.4   0.2    6.7  7  LRR_1      Leucine Rich Repeat
      0.095   12.7   0.0       0.18   11.9   0.0    1.4  1  DNMT1-RFD  Cytosine specific DNA methyltransferase replicatio


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0         3   1.1e+04       4      12 ..     107     115 ..     106     117 .. 0.78
   2 !   13.0   0.3   2.3e-05     0.082       2      23 ..     129     150 ..     128     151 .. 0.93
   3 ?    3.9   0.1     0.019        68       2      16 ..     156     170 ..     155     177 .. 0.90
   4 !    6.3   0.0    0.0032        11       3      24 .]     184     205 ..     182     205 .. 0.91
   5 !   13.5   0.0   1.6e-05     0.058       4      23 ..     211     230 ..     208     231 .. 0.91
   6 !   20.9   0.3   6.6e-08   0.00024       3      23 ..     237     257 ..     235     258 .. 0.88
   7 !   14.1   0.2     1e-05     0.037       4      17 ..     262     275 ..     259     276 .] 0.89

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3
       LRR_6   4 hLteLdLsg 12 
                 ++++L L++
  EFC35626.1 107 NMKKLKLAC 115
                 789999987 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 2.3e-05
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  ++LteL + + +I+++G++aL
  EFC35626.1 129 LRNLTELRIVDSNISNDGGIAL 150
                 589******************9 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.019
       LRR_6   2 nthLteLdLsgNdIg 16 
                  ++L+ L+L +N++g
  EFC35626.1 156 LQNLKFLQLDDNELG 170
                 589*********998 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0032
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 t+L++L+L  N + DeG++ L+
  EFC35626.1 184 TNLESLSLDINFLRDEGLKYLS 205
                 89****************9885 PP

  == domain 5  score: 13.5 bits;  conditional E-value: 1.6e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt+L+L+ NdI+ +Ga+ +
  EFC35626.1 211 KLTYLSLARNDISHKGASYI 230
                 7****************987 PP

  == domain 6  score: 20.9 bits;  conditional E-value: 6.6e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 + L++L+L+gN+I+DeG+  +
  EFC35626.1 237 SQLKHLNLNGNHISDEGIYEI 257
                 67***************9877 PP

  == domain 7  score: 14.1 bits;  conditional E-value: 1e-05
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +Lt+L+LsgN+I+ 
  EFC35626.1 262 TLTSLHLSGNQITT 275
                 9***********96 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       1.1     4e+03      17      30 ..      74      86 ..      55     103 .. 0.59
   2 !    6.0   1.7    0.0046        17       5      33 ..     110     140 ..     106     150 .. 0.66
   3 ?    3.4   0.6     0.032   1.1e+02      20      33 ..     154     167 ..     141     172 .. 0.69
   4 !   10.6   5.1   0.00017       0.6       1      38 [.     157     198 ..     157     232 .. 0.78
   5 !   16.4   1.3   2.5e-06     0.009       2      37 ..     211     250 ..     210     253 .. 0.74
   6 !   25.3   1.7     4e-09   1.4e-05       2      37 ..     238     274 ..     237     276 .] 0.86

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.1
                S-HHH-TT--EEE- CS
       LRR_4 17 plleklpnLkeLdL 30
                + l  +  L  L+L
  EFC35626.1 74 DELL-FERLDGLSL 86
                3333.444444445 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0046
                 EEE--.SS---.E-S-HHH-TT--EEE-.-S CS
       LRR_4   5 vLdLs.nNqlt.diplleklpnLkeLdLsgN 33 
                 +L L+ + +l   ++  ++l nL+eL + + 
  EFC35626.1 110 KLKLAcSQKLAiQLSERNNLRNLTELRIVDS 140
                 5555543367733555778********9554 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.032
                 HH-TT--EEE-.-S CS
       LRR_4  20 eklpnLkeLdLsgN 33 
                 e+l nLk L L +N
  EFC35626.1 154 ENLQNLKFLQLDDN 167
                 46777777777555 PP

  == domain 4  score: 10.6 bits;  conditional E-value: 0.00017
                 SS--EEE--SS---.E-S-...HH...H-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqlt.dipl...le...klpnLkeLdLsgNnlitd 38 
                 +nL++L L +N l  +  +   l+    ++nL++L+L + n+++d
  EFC35626.1 157 QNLKFLQLDDNELGvK--FaksLSespYMTNLESLSL-DINFLRD 198
                 6999999999997733..3335334545999999999.7667765 PP

  == domain 5  score: 16.4 bits;  conditional E-value: 2.5e-06
                 S--EEE--SS---.E-S-.....HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqlt.dipl.....leklpnLkeLdLsgNnlit 37 
                 +L++L+L+ N ++ +  +     ++ l +Lk+L+L+gN  i+
  EFC35626.1 211 KLTYLSLARNDIShKGASyisssFN-LSQLKHLNLNGN-HIS 250
                 79******99976553334332255.*********999.554 PP

  == domain 6  score: 25.3 bits;  conditional E-value: 4e-09
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L++L+L++N+++d +   +++l  L++L+LsgN +it
  EFC35626.1 238 QLKHLNLNGNHISDEGIyeISQLETLTSLHLSGN-QIT 274
                 7*************99955447999*********.776 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   4.8    0.0003       1.1       2      61 .]     107     169 ..     106     169 .. 0.80
   2 !    8.0   5.1   0.00068       2.4       1      57 [.     130     192 ..     130     196 .. 0.78
   3 !    6.6   2.3    0.0018       6.6       2      40 ..     185     225 ..     184     231 .. 0.84
   4 !   23.8   6.2     8e-09   2.9e-05       3      61 .]     212     273 ..     211     273 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0003
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G...GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt...lspgafsgLpsLrsLdLsgNrL 61 
                 n ++L L +++  +++ +  ++l+nL++L + + +++    +    +++L +L++L L++N L
  EFC35626.1 107 NMKKLKLACSQKLAIQLSERNNLRNLTELRIVDSNISNdggIALVQCENLQNLKFLQLDDNEL 169
                 889999999999999999999***************984445555556677777788888865 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00068
                 TT-SEEE-TTS--SEE-TTSS...TT-TT--EEE--SS---GGGGGGGTT...--S-.EEE-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaF...kglsnLkvLdLsnNllttlspgafsg...LpsLrsLdLs 57 
                 +nLt+L + ++++++ +  a    ++l+nLk L+L +N+l +  ++++s    +++L+sL L+
  EFC35626.1 130 RNLTELRIVDSNISNDGGIALvqcENLQNLKFLQLDDNELGVKFAKSLSEspyMTNLESLSLD 192
                 69***********99888776222679999999******999888988863335677777776 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.0018
                 T-SEEE-TTS--SEE-TTSSTT..-TT--EEE--SS---GG CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg..lsnLkvLdLsnNllttl 40 
                 nL+sL+L+ N l + + +  ++    +L++L+L +N +++ 
  EFC35626.1 185 NLESLSLDINFLRDEGLKYLSNssTLKLTYLSLARNDISHK 225
                 89999999999998888888885566889*******99985 PP

  == domain 4  score: 23.8 bits;  conditional E-value: 8e-09
                 -SEEE-TTS--SEE-TTSS...TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaF...kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 Lt+L+L +N +++ + +     ++ls+Lk+L+L+ N ++      +s+L+ L+sL+LsgN++
  EFC35626.1 212 LTYLSLARNDISHKGASYIsssFNLSQLKHLNLNGNHISDEGIYEISQLETLTSLHLSGNQI 273
                 888999999998888764411145****************8889****************98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.6       2.7   9.8e+03       5       5 ..      84      84 ..      55     106 .. 0.59
   2 ?   -0.9   0.0       1.2   4.4e+03       1      11 [.     131     142 ..     131     152 .. 0.64
   3 ?    3.3   0.1     0.053   1.9e+02       1      21 [.     158     178 ..     158     180 .. 0.88
   4 ?    1.1   0.5      0.28     1e+03       1      16 [.     185     200 ..     185     207 .. 0.73
   5 ?    5.2   0.0     0.012        43       1      21 [.     211     231 ..     211     234 .. 0.88
   6 ?   10.4   0.2   0.00025      0.89       1      16 [.     238     253 ..     238     260 .. 0.79
   7 ?    4.2   0.0     0.026        92       2      12 ..     263     273 ..     262     276 .] 0.87

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.7
       LRR_1  5 L 5 
                L
  EFC35626.1 84 L 84
                2 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.2
       LRR_1   1 nLrhLdL.snnp 11 
                 nL++L +  +n+
  EFC35626.1 131 NLTELRIvDSNI 142
                 899998733333 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.053
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL+ L L +n l+ + + s++
  EFC35626.1 158 NLKFLQLDDNELGVKFAKSLS 178
                 8***********988888875 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.28
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 nL++L L  n+l + +
  EFC35626.1 185 NLESLSLDINFLRDEG 200
                 89***99888885554 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.012
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L L +n ++++++++++
  EFC35626.1 211 KLTYLSLARNDISHKGASYIS 231
                 79**********999988776 PP

  == domain 6  score: 10.4 bits;  conditional E-value: 0.00025
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L+hL+L++n++++ +
  EFC35626.1 238 QLKHLNLNGNHISDEG 253
                 59*********97665 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.026
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L+Ls+n++
  EFC35626.1 263 LTSLHLSGNQI 273
                 99*******98 PP

>> DNMT1-RFD  Cytosine specific DNA methyltransferase replication foci domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0     5e-05      0.18      97     128 ..       1      32 [.       1      44 [. 0.88

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5e-05
                 -SB-TTTHHHHHHHHHHHHHHHHHHHHHHHHT CS
   DNMT1-RFD  97 lkPsaeYapiyekviekarlsvevvkfLkrsp 128
                 +kP ++Ya++++ ++e++++ + +++f+  sp
  EFC35626.1   1 MKPTKSYAKVIHPLQEQFDMMYLIFEFIGISP 32 
                 8*************************998777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       361  (0.020135); expected 358.6 (0.02)
Passed bias filter:                      237  (0.0132188); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 1844.17
//
Query:       EFC35627.1  [L=319]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.6e-12   45.5   0.2    9.8e-12   44.4   0.2    1.6  1  TFA2_Winged_2  TFA2 Winged helix domain 2
  ------ inclusion threshold ------
          4    8.1   8.3        1.9    9.1   1.0    3.0  3  Nexin_C        Sorting nexin C terminal


Domain annotation for each model (and alignments):
>> TFA2_Winged_2  TFA2 Winged helix domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.4   0.2   1.1e-15   9.8e-12       2      61 .]     166     225 ..     165     225 .. 0.93

  Alignments for each domain:
  == domain 1  score: 44.4 bits;  conditional E-value: 1.1e-15
  TFA2_Winged_2   2 nkeeLlalLkkrp.kaeGikvkdLkdswpdveealeeLeaegeilvlrtkkdgqpkiVfwN 61 
                     k+  l+lL++ +   +Gi+v++L +s+++v +++eeL++e+ ++ + + +d++ +i+++N
     EFC35627.1 166 EKKHVLELLQNPEfVISGIPVSELAESYKGVLNDIEELKKEKAVISIPN-QDKKCDILYFN 225
                    6888999998887669*******************************88.9*********9 PP

>> Nexin_C  Sorting nexin C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.2      0.26   2.4e+03      59      80 ..      42      63 ..      26      76 .. 0.65
   2 ?    1.5   0.7     0.048   4.3e+02      60      90 ..      97     127 ..      50     129 .. 0.74
   3 ?    9.1   1.0   0.00021       1.9      45      88 ..     266     314 ..     258     316 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.26
     Nexin_C 59 esaperseeeklrtraearklL 80
                e +p+ +++ek +++a  + +L
  EFC35627.1 42 EATPTLTKQEKAQKKATKEHTL 63
                4455566666665555555544 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.048
     Nexin_C  60 saperseeeklrtraearklLlellpdalvs 90 
                 ++++ +eeek++t  +++ +L ++l d +++
  EFC35627.1  97 TNEVDEEEEKEKTGVKFEDSLAAHLDDRIKK 127
                 45678999999***99999999988887776 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00021
     Nexin_C  45 klrdalWPdgeskaesaperseeekl....rtraearklLle.llpdal 88 
                  ++   WP++e ++++++er+e+ k+    rtr+  +k++ + +l +++
  EFC35627.1 266 AIQTVEWPEDEHRKKKEAEREENAKNtktkRTRKMNVKKMTNkHLAEEF 314
                 678888**99888888899999999655668888888888777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2318  (0.129288); expected 358.6 (0.02)
Passed bias filter:                      593  (0.0330749); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 1915.36
//
Query:       EFC35628.1  [L=1255]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.9e-06   27.8   1.5    4.3e-06   27.2   0.1    2.1  2  HATPase_c    Histidine kinase-, DNA gyrase B-, and HSP90-like
      0.004   17.0   0.0      0.012   15.5   0.0    1.8  1  HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like
     0.0062   16.4   1.3      0.031   14.2   1.3    2.2  1  Elf4         Early Flowering 4 domain
  ------ inclusion threshold ------
        5.4    6.8   9.3        2.3    8.0   4.3    2.6  2  Lectin_N     Hepatic lectin, N-terminal domain


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   0.1   9.6e-10   4.3e-06       1      62 [.      26     110 ..      26     125 .. 0.79
   2 ?   -2.8   0.2         2     9e+03       2      21 ..     789     817 ..     788     842 .. 0.54

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 9.6e-10
                 EHHHHHHHHHHHHHHHHHHH..........HSTTTEEEEEEEEEETEEEEEEEESSSSSTTHHHT.............GTCSTTC CS
   HATPase_c   1 gdekrLrqiisnlvdNavkf..........atkageieveikaseddlvisveDnGiGipkedlk.............klfekfs 62 
                 ++e++Lr++isn++d+++k             ++ e++++i +++++++++++D+G G++k+dl               +f+ f 
  EFC35628.1  26 NKEIFLRELISNASDALDKLrhisltepsvLDSERELFIHIIPDKVNKTLTIRDSGLGMTKADLInclihtsaennlqDMFAQFL 110
                 5899****************8888776543336668899999888******************9988777777765555555444 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2
                 HHHHHHHHHHHHHHHHHHH.........H CS
   HATPase_c   2 dekrLrqiisnlvdNavkf.........a 21 
                 d+k +r+ ++ +v+N +k+         +
  EFC35628.1 789 DSKVFREYVDDVVKNHLKIgdifglnenE 817
                 56677888888888888886666554331 PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   2.6e-06     0.012       1      55 [.      24      94 ..      24     113 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 2.6e-06
  HATPase_c_3  1 ysl.ekAlaelvdNsldAdaen..................vkievnknrgktgeivieDdGkGmseeelknalr 55
                 ys+ e+ l el+ N+ dA  +                   ++i  +k    +++++i+D G Gm++++l+n l 
   EFC35628.1 24 YSNkEIFLRELISNASDALDKLrhisltepsvldserelfIHIIPDKV---NKTLTIRDSGLGMTKADLINCLI 94
                 566688899*********877767888888998888887777766665...48******************763 PP

>> Elf4  Early Flowering 4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   1.3   6.9e-06     0.031      23      55 ..     316     348 ..     299     358 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 6.9e-06
        Elf4  23 qNrlLIqevneNhesripdnlsrnvaLirelNg 55 
                 +N++LI+e+n Nh+s i +  ++   L+ e+N+
  EFC35628.1 316 RNKSLISEMNTNHQSLILELDTKHQMLVSEMNQ 348
                 8*******************************7 PP

>> Lectin_N  Hepatic lectin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.2      0.17   7.5e+02      88     113 ..     198     223 ..     170     229 .. 0.74
   2 ?    8.0   4.3   0.00051       2.3      64     122 ..     321     383 ..     300     390 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.17
    Lectin_N  88 kvtsleaklekkqqdlkadhselllh 113
                  ++sl+ k+e  +++ ++d+s+ +l 
  EFC35628.1 198 IMNSLKKKIETLNKEQEEDKSQYFLE 223
                 57899999999999999999998775 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00051
    Lectin_N  64 fsnfssstlaeiqalss....qggslsekvtsleaklekkqqdlkadhselllhvkqlvkdLr 122
                 +s++ +++++ i +l++      ++++++  +  ++le+++++l+ d s++ll +++ +  + 
  EFC35628.1 321 ISEMNTNHQSLILELDTkhqmLVSEMNQRYMTKLSELEEENKQLRVDTSNFLLELQHSKLRID 383
                 4555556666666666533323577888888999**********************9766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1823  (0.101679); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.04u 0.34s 00:00:01.38 Elapsed: 00:00:00.58
# Mc/sec: 6503.05
//
Query:       EFC35629.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       625  (0.0348597); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 2016.86
//
Query:       EFC35630.1  [L=791]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (791 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1359  (0.075799); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.78u 0.31s 00:00:01.09 Elapsed: 00:00:00.50
# Mc/sec: 4727.18
//
Query:       EFC35631.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       622  (0.0346924); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1047.40
//
Query:       EFC35632.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.1e-78  262.7   0.0    6.2e-78  262.4   0.0    1.0  1  Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase famil
  ------ inclusion threshold ------
       0.25   10.4   0.1         27    3.7   0.0    2.6  2  Dus           Dihydrouridine synthase (Dus)


Domain annotation for each model (and alignments):
>> Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  262.4   0.0   6.9e-82   6.2e-78       2     339 ..      12     354 ..      11     356 .. 0.89

  Alignments for each domain:
  == domain 1  score: 262.4 bits;  conditional E-value: 6.9e-82
                   CCS-EEETTEEESSSEEE----S-TTTTTCS.HHHHHHHHHHHHHHTT-SEEEEEEEESSCCC-SCTTSEE-SSGGGHHHHHHHHHHHHHTT-EEEE CS
  Oxidored_FMN   2 LFkPikignmtLknRivmapmtrlraldkgnvledlaaeyysqraeipvtliiteaafvnpksggfdnapgiwdeeqieewrklteavhengskvvv 98 
                   LF+P+ki   tLknRiv++pm+++++ d    ++++ ++++  r  ++ +l i+ea+ v+  +++ ++  gi+++e++  + k+ +  he+g+ +++
    EFC35632.1  12 LFQPFKIRGLTLKNRIVVSPMCQYSSVDGF--ANFWHVQHIGSRIVGGAGLFIVEATGVSDIGRISPGCLGIYKDEHVDMLSKICQFTHEQGGHIGI 106
                   9***********************999865..99*************************************************************** PP

                   EEE--GGGS..SCSTCEC...............SS.ESSSSSTTT-.S...CS-EE--HHHHHHHHHHHHHHHHHHHHTT-SEEEEEE-CTSHHHHH CS
  Oxidored_FMN  99 qlwhlGreakseyladqe.............vdspsdpvaldaqeeesaeevykkeltkeeikqliqefveAAkraieAgfDgVeihganGYLlnqF 182
                   q+ h+Gr+a +  l ++              v +ps p+a+d++     ++v + el+ e+i+++iq+fv+AAkra++AgfD++eihga+GYL+  F
    EFC35632.1 107 QIGHAGRKASTGRLWEALgrkaltneeggwdVIGPS-PIAFDDN-----HKV-PAELSIEQIQEVIQQFVDAAKRAVKAGFDVIEIHGAHGYLISSF 196
                   *********876655554566788855555555555.5555555.....344.77****************************************** PP

                   H-TTT----STTSSSHHHHHHHHHHHHHHHHHHH-SSS.EEEEEECE--STT.S--HHHHHHHHHHHCHCCEEEEEEETT-SSSSSTTS-TTTTHHH CS
  Oxidored_FMN 183 lspksnkrtDeygGslenRarFllevvdaVkeavgeer.vgyRlSpedvvek.gldfaetaqkivllkelekrlkdgkklalvhaaeprkrgagsvr 277
                   lsp sn+rtD ygGs enR+rFl+e+v+ ++e +  e+ +++R+S++++v++ g ++ +t++ +++l + +++l+d++++     + ++k ++   +
    EFC35632.1 197 LSPTSNQRTDAYGGSFENRIRFLIEIVQRIRENIPTEMpLFVRVSADEYVGEeGWTMKDTTELAKILRDSGVDLLDCSSGGN---NAKAKISPIGIV 290
                   ************************************************997516788899999************9999864...445566888888 PP

                   CCTT.HHHHHHCCCH.SSEEEE-SS--SHHHHHHHHHTTS-SEEEESTHHHH-TTHHHHHHCCT CS
  Oxidored_FMN 278 teqe.kntefvkevw.kkplitvgriadeekaaeivaegeadLvamgRefladpdlveklkkgl 339
                     ++  + e vk+ +   ++ +vg+i +++ a++ v+ g+adLv +gR+ l dp ++ +++++l
    EFC35632.1 291 QGYQvPFSEGVKKSVdGLATGAVGKIVEAKFANDLVKDGKADLVLIGRQDLNDPYWPIRAAQDL 354
                   8888788887776551579****************************************99987 PP

>> Dus  Dihydrouridine synthase (Dus)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0    0.0031        27     133     159 ..     161     187 ..     144     208 .. 0.80
   2 ?    3.6   0.0    0.0033        30     178     222 ..     301     346 ..     198     357 .. 0.64

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.0031
                 SSTTTC.HHHHHHHHHHCT-SEEEEES CS
         Dus 133 iddeeenalelakiveaaGaqaltvHg 159
                 i++  ++ +++ak++ +aG + + +Hg
  EFC35632.1 161 IQEVIQQFVDAAKRAVKAGFDVIEIHG 187
                 55777899******************9 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.0033
                 HHHH-S.S-EEEESS--SHHHHHHHHHHH--SEEEESCHHCCSTTH CS
         Dus 178 vkqavs.ipviaNGdIkdaedaqaileetGadgvmigrgalgnPwl 222
                 vk++v  +   a G I +a+ a++ ++   ad v+igr  l++P+ 
  EFC35632.1 301 VKKSVDgLATGAVGKIVEAKFANDLVKDGKADLVLIGRQDLNDPYW 346
                 5666666666777888888888888888888899999999998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       501  (0.0279436); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2262.80
//
Query:       EFC35633.1  [L=178]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.036   14.0   0.1      0.063   13.2   0.1    1.3  1  Gag_p10   Retroviral GAG p10 protein


Domain annotation for each model (and alignments):
>> Gag_p10  Retroviral GAG p10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   3.5e-06     0.063      35      75 ..      55      97 ..      44     101 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.5e-06
                H-THHHH.H--SSHHHHHHHHHHHHHHHHHH-GG.GS-TTHHH CS
     Gag_p10 35 vcPWfpe.eGtlnletWkkvgkelkkqatehGpe.kipvdvlp 75
                vc +fp+ e +ln+++W +v ++ k ++++hG + +ip ++++
  EFC35633.1 55 VCFYFPRfEKALNIKNWMHVLRRRKAHIKIHGNDfRIPSETWN 97
                67889976889*********************87679999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1103.44
//
Query:       EFC35634.1  [L=121]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-07   32.2   0.3    3.1e-07   30.9   0.1    1.7  2  RA        Ras association (RalGDS/AF-6) domain
    1.2e-05   25.2   0.0    1.9e-05   24.5   0.0    1.3  1  FERM_N    FERM N-terminal domain


Domain annotation for each model (and alignments):
>> RA  Ras association (RalGDS/AF-6) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   0.1   3.5e-11   3.1e-07       2      75 ..       4      70 ..       3      88 .. 0.92
   2 ?   -0.7   0.0      0.25   2.3e+03      65      91 ..      85     108 ..      71     110 .. 0.67

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 3.5e-11
                ECEEEEEETTT-TT..EEEEEEETTSBHHHHHHHHHHHCT-GGGGCCEEEECCCTTTTEEEEE-TTSBCHHHHC CS
          RA  2 tgvlkVytedlkpgttyksikvsststaqeViealLekfgledspedyvLveskerggeerkLdddecplqiql 75
                + v++Vy  d++    +k+i vs t +a+++   +++k  l ++ e+++L     + ge+r Lddde+p +++ 
  EFC35634.1  4 KLVIRVYFVDDS----FKTIAVSPTISARDLSIVVADKIEL-EQRETFAL--FFYKNGECRCLDDDEQPCKLMV 70
                569*********....*************************.********..6778899**********99986 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.25
                 -TTSBCHHHHCCC-TTTSTCEEEEEEC CS
          RA  65 dddecplqiqlqwkkreeslrFvLrek 91 
                 +d+  + ++++ w+k   ++++v++++
  EFC35634.1  85 NDKQEWEKLKKDWEK---DSKLVFKRR 108
                 455555566666766...677777776 PP

>> FERM_N  FERM N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.5   0.0   2.2e-09   1.9e-05       1      58 [.       9      64 ..       9      71 .. 0.91

  Alignments for each domain:
  == domain 1  score: 24.5 bits;  conditional E-value: 2.2e-09
                EE-TTS-EEEEEEETTSSHHHHHHHHHHHHT-S-GGGEEEEE--SSS-SXEEE-SSS- CS
      FERM_N  1 VrlLDgtvkeitvddsktvtdlLdtVcarigltehdyFgLvfmeekkdegnWLdhskt 58
                V ++D+++k+i+v++   ++dl   V+ +i+l++ + F L+f   k++e + Ld++ +
  EFC35634.1  9 VYFVDDSFKTIAVSPTISARDLSIVVADKIELEQRETFALFF--YKNGECRCLDDDEQ 64
                5699**************************************..99999999998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (121 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       788  (0.0439511); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.26s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 862.42
//
Query:       EFC35635.1  [L=193]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-37  129.8   0.0    1.6e-37  129.6   0.0    1.0  1  Peptidase_S15  X-Pro dipeptidyl-peptidase (S15 family)
    0.00013   21.7   0.1    0.00016   21.4   0.1    1.1  1  Abhydrolase_1  alpha/beta hydrolase fold
    0.00014   21.5   0.0    0.00019   21.0   0.0    1.2  1  Peptidase_S9   Prolyl oligopeptidase family
    0.00022   20.6   0.0    0.00029   20.2   0.0    1.1  1  Hydrolase_4    Serine aminopeptidase, S33


Domain annotation for each model (and alignments):
>> Peptidase_S15  X-Pro dipeptidyl-peptidase (S15 family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  129.6   0.0   3.6e-41   1.6e-37       1     164 [.       3     173 ..       3     185 .. 0.91

  Alignments for each domain:
  == domain 1  score: 129.6 bits;  conditional E-value: 3.6e-41
                    TS-EEEEEEEEE....TTSSSEEEEEEEESS-CCT.CCCCHTTCHHCCHGGGHH.....HHHTT-EEEEEE-TTSTTS-S---TT.TTTHHHHHHH CS
  Peptidase_S15   1 DGvrLavdiyrP..etkskeklPvlltrtPYgkndelasdkalaleelelqdkv.....fvarGYavVvqdvrGtggSeGeftvg.dsdeaedgad 88 
                    DGv++a d+y+P    +++++lP+ll+ t+Y+++  +++   ++l +++l+        fvarGYavV  d+rGtg+S G +    ++de++d+ +
     EFC35635.1   3 DGVKIACDLYLPyrAVNENHRLPTLLHITRYNRSF-KVNFPFNYLFGEKLSIRGipfkkFVARGYAVVSCDTRGTGASFGSRPYDfHRDEVQDFGE 97 
                    9************999****************877.78888888877766655588999**********************988879********* PP

                    HHHHHHHCTTEEEEEEEEEECHHHHHHHHHCTT--TTEEEEEEECE-S-TCCCCSECTTEEBCCHHHHHHHHHCCC CS
  Peptidase_S15  89 vidWlakqpwsnGkVgmtGiSYlGttqllaaatgvpalkaivpeaaisdlyddyyregGlvrapgglswedldlla 164
                    + dW++kq++snGk+  tGiSY+G+++  + + +++ l a++++++ +dly+d++++gGl ++ +++  ++ + + 
     EFC35635.1  98 IMDWVVKQKFSNGKIVSTGISYDGMVSDFLVSLNHKSLVAVASVSSPFDLYRDIIYPGGLYQKSFIDHYLKFTQHV 173
                    ***************************************************************9999886555554 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.1   3.6e-08   0.00016      26     116 ..      63     150 ..      46     179 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 3.6e-08
                    HHTTSEEEEEEETTSTTSSSTTTGB.CHHSHHHHH...HHHHHH.HHHCTTSSEEEEEETHHHHHHHHHHHHHGGGEEEEEEESECSSCCHHHHH CS
  Abhydrolase_1  26 akdgfdvillDlrGvgySspapacinddygtasva...ddldri.ldalgddkltlvGhSmGGmialayaaeyperVkalvllgaidpaasliea 116
                    a+ g+ v+  D rG g S  +      d++ + v+   +++d++ ++++ ++k++  G S+ Gm++  + +++ ++  a++++++   +++l ++
     EFC35635.1  63 AR-GYAVVSCDTRGTGASFGSRP---YDFHRDEVQdfgEIMDWVvKQKFSNGKIVSTGISYDGMVSDFLVSLNHKSLVAVASVSS---PFDLYRD 150
                    33.***************99999...7885555550006677889***********************99998776666777666...5554444 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   4.2e-08   0.00019      10      92 ..      61     139 ..      56     166 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 4.2e-08
                   HHCCT-EEEEE--TTSSTTHCHHHHTTSGGGGHHHHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHHHHHHHH.H-GGG-SEE CS
  Peptidase_S9  10 ladrGyvvvvanirGsggyGeafhdagkrklgqnefdDfiaaaealakegyvdserlaitGgSyGGyltgaaln.qrpdlFkaa 92 
                   + +rGy+vv ++ rG+g    +f  +  ++    e++Df +++++++k+++  + +++ tG Sy G+++  ++  ++++l ++a
    EFC35635.1  61 FVARGYAVVSCDTRGTG---ASFGSR-PYDFHRDEVQDFGEIMDWVVKQKFS-NGKIVSTGISYDGMVSDFLVSlNHKSLVAVA 139
                   448************98...666663.45577889***************97.789***********99887774444444333 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   6.5e-08   0.00029      25     111 ..      59     145 ..      55     175 .. 0.80

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 6.5e-08
  Hydrolase_4  25 eaLaaqGfavyalDhrGhGrsegkrghvpsfddyvdDlaafvekvk.eehpelplfllGhSmGGliallyl.lrypdkvaglilsaPal 111
                  ++++a+G+av+  D rG G s g r   +   d v+D+ ++++ v+ ++ ++ +++  G S  G+++  ++ l++++ + ++  +++ +
   EFC35635.1  59 KKFVARGYAVVSCDTRGTGASFGSRP-YDFHRDEVQDFGEIMDWVVkQKFSNGKIVSTGISYDGMVSDFLVsLNHKS-LVAVASVSSPF 145
                  7899******************9999.67778899*******99995777777********9999987776355555.55444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (193 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       398  (0.0221987); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1218.79
//
Query:       EFC35636.1  [L=1041]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   7.1e-104  339.9  46.7    2.3e-15   56.5   0.3   15.1 14  PPR_2          PPR repeat family
    2.6e-66  215.4  32.9    1.8e-07   31.0   0.0   22.7 22  PPR            PPR repeat
    3.9e-60  199.8  37.0      2e-09   37.4   0.1   12.4 12  PPR_3          Pentatricopeptide repeat domain
    2.6e-34  116.6  36.9     0.0029   17.3   0.0   17.1 18  PPR_1          PPR repeat
    3.6e-30  104.9   6.2    5.2e-06   26.0   0.1    7.2  6  PPR_long       Pentacotripeptide-repeat region of PRORP
      9e-27   93.5   2.4    2.8e-26   91.9   0.6    2.8  2  DYW_deaminase  DYW family of nucleic acid deaminases
    1.3e-11   44.6   4.5     0.0042   17.3   0.1    6.0  5  TUG-UBL1       TUG ubiquitin-like domain
    3.1e-08   34.0   0.0        1.9    9.0   0.0    6.7  7  TPR_19         Tetratricopeptide repeat
    3.8e-07   29.3   5.5      0.091   11.6   0.0    5.5  7  MRP-S27        Mitochondrial 28S ribosomal protein S27
    4.2e-06   26.6  14.4          4    7.3   0.0   10.0 12  ATP13          Mitochondrial ATPase expression
    9.5e-05   22.3   0.1         45    4.2   0.0    6.2  5  PHB_acc        PHB accumulation regulatory domain
    0.00017   20.8   6.2        2.9    6.9   0.0    6.2  7  ECSIT          Evolutionarily conserved signalling intermedia
    0.00033   20.3   0.0         15    5.6   0.0    5.3  5  TPR_1          Tetratricopeptide repeat
     0.0028   17.7   0.8         15    5.7   0.0    5.4  7  Ocnus          Janus/Ocnus family (Ocnus)
     0.0089   16.1   0.7          2    8.4   0.0    3.5  4  Katanin_con80  con80 domain of Katanin
  ------ inclusion threshold ------
      0.045   14.0   2.1         58    4.3   0.0    6.1  7  TPR_8          Tetratricopeptide repeat
      0.051   13.9   4.6       0.43   11.0   0.1    4.0  3  Uteroglobin    Uteroglobin family
      0.097   13.0   0.0        8.3    6.8   0.1    3.5  3  TPR_12         Tetratricopeptide repeat
       0.18   12.0   0.0         62    4.1   0.0    4.9  6  TPR_2          Tetratricopeptide repeat
       0.28   11.2   5.2         19    5.3   0.1    4.5  4  Nrap           Nrap protein domain 1
        1.1    9.1  21.8        4.1    7.3   0.5    6.9  8  Clathrin       Region in Clathrin and VPS


Domain annotation for each model (and alignments):
>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.2   3.7e-05     0.032       2      37 ..       2      37 ..       1      47 [. 0.95
   2 !   56.5   0.3   2.7e-18   2.3e-15       3      50 .]     106     153 ..     104     153 .. 0.96
   3 !    8.1   0.0    0.0034       2.9       7      34 ..     181     208 ..     176     210 .. 0.93
   4 !   40.5   0.2   2.7e-13   2.3e-10       2      50 .]     210     258 ..     209     258 .. 0.98
   5 !   29.1   0.0   9.5e-10   8.1e-07      17      49 ..     303     335 ..     285     336 .. 0.88
   6 ?    2.0   0.0      0.29   2.4e+02       9      35 ..     365     391 ..     363     394 .. 0.88
   7 !   53.4   0.1   2.6e-17   2.2e-14       2      49 ..     392     439 ..     391     440 .. 0.96
   8 !   20.3   0.1   5.6e-07   0.00048      24      48 ..     464     488 ..     460     490 .. 0.91
   9 !   43.3   0.1   3.6e-14   3.1e-11       2      49 ..     547     594 ..     546     595 .. 0.97
  10 !   26.7   0.1   5.5e-09   4.7e-06       2      48 ..     652     708 ..     651     710 .. 0.90
  11 !   49.7   2.7   3.6e-16     3e-13       2      49 ..     769     816 ..     768     817 .. 0.95
  12 !   16.0   0.2   1.2e-05      0.01       9      49 ..     811     852 ..     811     853 .. 0.92
  13 ?    4.8   0.0     0.039        33       5      30 ..     843     868 ..     839     872 .. 0.83
  14 ?    4.9   0.3     0.034        29       5      35 ..     872     902 ..     868     903 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 3.7e-05
       PPR_2  2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePn 37
                +v+ y++ I+ +  + ++e A+ +   Mk + +ePn
  EFC35636.1  2 NVFLYTHFINNCIWNDDLERALAIVLNMKGKDIEPN 37
                99*********************************9 PP

  == domain 2  score: 56.5 bits;  conditional E-value: 2.7e-18
       PPR_2   3 vvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglck 50 
                 ++t+N+lI+++ +++++++A+++ +eMk++g+ P+s T++ili+++++
  EFC35636.1 106 IITWNSLIQAYIQENNIKKAIDVIHEMKDNGICPDSATFNILITACAN 153
                 79*******************************************985 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.0034
       PPR_2   7 NtlIsglckkgkveeAfklfneMkkrgl 34 
                 +++I+ + k g++e A+   ++Mk++gl
  EFC35636.1 181 TSIINFYTKCGHPEIAINECEKMKSKGL 208
                 78************************98 PP

  == domain 4  score: 40.5 bits;  conditional E-value: 2.7e-13
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglck 50 
                 +vv++++l  ++ + +++++A++   eMk+ +++Pn+ T+sil+++++k
  EFC35636.1 210 NVVSFTCLVEAYIQINEIQKAIDTVTEMKQFKVTPNATTFSILLTACAK 258
                 9*********************************************987 PP

  == domain 5  score: 29.1 bits;  conditional E-value: 9.5e-10
       PPR_2  17 gkveeAfklfneMkkrglePnsyTysilikglc 49 
                 +++++A+++  eM++ g+ePns T++il+++++
  EFC35636.1 303 NEFRQAIEIITEMQDYGVEPNSTTFNILLTACA 335
                 6789***************************97 PP

  == domain 6  score: 2.0 bits;  conditional E-value: 0.29
       PPR_2   9 lIsglckkgkveeAfklfneMkkrgle 35 
                 + + + k g++e A+k  ++ k++gl 
  EFC35636.1 365 IVNFYTKCGHPETAIKECEQLKSKGLM 391
                 678899******************995 PP

  == domain 7  score: 53.4 bits;  conditional E-value: 2.6e-17
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49 
                 + +++N+lI+++ ++++v++A+++  eM++ g+ePns T++il+k+++
  EFC35636.1 392 NNIVWNCLIQAYIQNKEVRQAIEVITEMQDYGIEPNSTTFNILLKACA 439
                 7799******************************************97 PP

  == domain 8  score: 20.3 bits;  conditional E-value: 5.6e-07
       PPR_2  24 klfneMkkrglePnsyTysilikgl 48 
                 +l n+M++ gl P+s Ty+i++k++
  EFC35636.1 464 ELNNKMQQFGLNPDSTTYTIILKAC 488
                 6789********************7 PP

  == domain 9  score: 43.3 bits;  conditional E-value: 3.6e-14
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49 
                 +v ++N+lI+++ + ++v + +k+  eM++ g+ePns T++il+++++
  EFC35636.1 547 NVAVWNCLIQAHIQTKEVPKSIKIITEMQDCGVEPNSTTFNILLTACA 594
                 99********************************************97 PP

  == domain 10  score: 26.7 bits;  conditional E-value: 5.5e-09
       PPR_2   2 dvvtyNtlIsglc..........kkgk.veeAfklfneMkkrglePnsyTysilikgl 48 
                 dv ++N+lI+++           + +  +++A+ +fneMk   +eP+ +Ty il+ g+
  EFC35636.1 652 DVAIWNCLIQAHIqsttntqnpsTIEYgLNKAMVVFNEMK-EHIEPDKITYLILLAGC 708
                 899*******************9655559***********.5799**********997 PP

  == domain 11  score: 49.7 bits;  conditional E-value: 3.6e-16
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49 
                 +++tyN ++s+++++gk  +A+ lfneM+ +++e+n+ T++i+++ + 
  EFC35636.1 769 SIITYNNMLSCYAQHGKGTQAMNLFNEMVAKNVEMNENTFTIMLNTFS 816
                 589*****************************************9875 PP

  == domain 12  score: 16.0 bits;  conditional E-value: 1.2e-05
       PPR_2   9 lIsglckkgkveeAfklfneMkkr.glePnsyTysilikglc 49 
                 +++ + + g+++eA +l+ eMk + +  P+++  +++++ ++
  EFC35636.1 811 MLNTFSHCGMIDEANQLYGEMKTKyNHNPSVIVDCVMVDVFA 852
                 8999*******************8799****99999998876 PP

  == domain 13  score: 4.8 bits;  conditional E-value: 0.039
       PPR_2   5 tyNtlIsglckkgkveeAfklfneMk 30 
                 +  ++ + +++ g+++eA k+ ne  
  EFC35636.1 843 VDCVMVDVFARSGRFHEAEKIINERM 868
                 556799*****************975 PP

  == domain 14  score: 4.9 bits;  conditional E-value: 0.034
       PPR_2   5 tyNtlIsglckkgkveeAfklfneMkkrgle 35 
                  + +l++g+ k ++ve+A  + + M ++g++
  EFC35636.1 872 LWSALMAGCRKFNNVEKADNIRQLMIENGIK 902
                 699*************************996 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0     0.013        11       2      30 ..       5      33 ..       4      34 .. 0.92
   2 !   31.0   0.0   2.1e-10   1.8e-07       1      31 []     107     137 ..     107     137 .. 0.97
   3 ?    4.9   0.0     0.044        37       2      19 ..     143     160 ..     142     165 .. 0.83
   4 ?    6.8   0.0      0.01       8.7       4      31 .]     181     208 ..     179     208 .. 0.94
   5 !   10.2   0.0   0.00088      0.75       1      29 [.     212     240 ..     212     242 .. 0.94
   6 ?    5.6   0.0     0.026        22       2      22 ..     248     268 ..     247     270 .. 0.88
   7 ?    2.9   0.0      0.19   1.6e+02       4      20 ..     286     302 ..     284     320 .. 0.69
   8 !    7.0   0.0    0.0094         8       2      24 ..     326     348 ..     325     349 .. 0.90
   9 ?    0.9   0.0      0.81   6.9e+02       6      30 ..     365     389 ..     364     390 .. 0.76
  10 !   22.6   0.0   9.8e-08   8.3e-05       2      31 .]     395     424 ..     394     424 .. 0.96
  11 ?    6.8   0.0     0.011       9.1       2      22 ..     430     450 ..     429     452 .. 0.89
  12 ?    3.9   0.0     0.087        74       2      25 ..     480     503 ..     479     507 .. 0.87
  13 ?    1.0   0.0      0.77   6.6e+02       4      17 ..     517     530 ..     515     543 .. 0.90
  14 !   13.9   0.0   5.6e-05     0.048       2      31 .]     550     579 ..     549     579 .. 0.96
  15 !    7.0   0.0    0.0094         8       2      24 ..     585     607 ..     584     608 .. 0.90
  16 ?    0.3   0.0       1.2   1.1e+03       2      12 ..     655     665 ..     654     666 .. 0.84
  17 ?    3.9   0.1     0.091        78      17      28 ..     681     692 ..     680     693 .. 0.88
  18 ?   -1.7   0.1       5.6   4.8e+03       2      30 ..     700     728 ..     699     729 .. 0.63
  19 !   30.1   0.1   3.9e-10   3.3e-07       1      31 []     771     801 ..     771     801 .. 0.95
  20 !   20.2   0.1   5.7e-07   0.00049       2      29 ..     807     834 ..     806     835 .. 0.96
  21 !   10.5   0.0   0.00067      0.57       5      25 ..     846     866 ..     845     866 .. 0.94
  22 !   15.2   0.1   2.2e-05     0.019       2      31 .]     872     901 ..     871     901 .. 0.96

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.013
         PPR  2 tynslIsgycknGkleeAlelfkeMkekG 30
                 y+  I+ +  n +le Al +   Mk k+
  EFC35636.1  5 LYTHFINNCIWNDDLERALAIVLNMKGKD 33
                69************************986 PP

  == domain 2  score: 31.0 bits;  conditional E-value: 2.1e-10
         PPR   1 vtynslIsgycknGkleeAlelfkeMkekGi 31 
                 +t+nslI++y +++++++A+++++eMk++Gi
  EFC35636.1 107 ITWNSLIQAYIQENNIKKAIDVIHEMKDNGI 137
                 69***************************97 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.044
         PPR   2 tynslIsgycknGkleeA 19 
                 t+n+lI +++   ++ e 
  EFC35636.1 143 TFNILITACANTKLFAEG 160
                 9*********99988776 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.01
         PPR   4 nslIsgycknGkleeAlelfkeMkekGi 31 
                 +s+I+ y k+G +e A+   ++Mk+kG+
  EFC35636.1 181 TSIINFYTKCGHPEIAINECEKMKSKGL 208
                 89****************99***99996 PP

  == domain 5  score: 10.2 bits;  conditional E-value: 0.00088
         PPR   1 vtynslIsgycknGkleeAlelfkeMkek 29 
                 v++++l+ +y + +++++A++   eMk+ 
  EFC35636.1 212 VSFTCLVEAYIQINEIQKAIDTVTEMKQF 240
                 89*************************87 PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.026
         PPR   2 tynslIsgycknGkleeAlel 22 
                 t+++l+ +++k  +++e + +
  EFC35636.1 248 TFSILLTACAKLKLYKEGILI 268
                 9***************98765 PP

  == domain 7  score: 2.9 bits;  conditional E-value: 0.19
         PPR   4 nslIsgycknGkleeAl 20 
                 +s+I+ y k+G ++ A+
  EFC35636.1 286 TSIINFYTKCGHPDIAI 302
                 67777777777777654 PP

  == domain 8  score: 7.0 bits;  conditional E-value: 0.0094
         PPR   2 tynslIsgycknGkleeAlelfk 24 
                 t+n+l+ +++ + ++ee + ++k
  EFC35636.1 326 TFNILLTACADSKLFEEGKAIHK 348
                 9****************988765 PP

  == domain 9  score: 0.9 bits;  conditional E-value: 0.81
         PPR   6 lIsgycknGkleeAlelfkeMkekG 30 
                 +++ y k+G +e A++  +++k+kG
  EFC35636.1 365 IVNFYTKCGHPETAIKECEQLKSKG 389
                 6788**********98555555555 PP

  == domain 10  score: 22.6 bits;  conditional E-value: 9.8e-08
         PPR   2 tynslIsgycknGkleeAlelfkeMkekGi 31 
                 ++n+lI++y +n +++ A+e++ eM++ Gi
  EFC35636.1 395 VWNCLIQAYIQNKEVRQAIEVITEMQDYGI 424
                 8**************************997 PP

  == domain 11  score: 6.8 bits;  conditional E-value: 0.011
         PPR   2 tynslIsgycknGkleeAlel 22 
                 t+n+l+++++ + ++ee + l
  EFC35636.1 430 TFNILLKACADSKLFEEGKLL 450
                 9****************8766 PP

  == domain 12  score: 3.9 bits;  conditional E-value: 0.087
         PPR   2 tynslIsgycknGkleeAlelfke 25 
                 ty+++++++   +++ee + ++++
  EFC35636.1 480 TYTIILKACTDFNLFEEGKLIHEQ 503
                 9****************9888776 PP

  == domain 13  score: 1.0 bits;  conditional E-value: 0.77
         PPR   4 nslIsgycknGkle 17 
                 +s+Is y k+G +e
  EFC35636.1 517 TSIISFYTKCGHPE 530
                 89*********998 PP

  == domain 14  score: 13.9 bits;  conditional E-value: 5.6e-05
         PPR   2 tynslIsgycknGkleeAlelfkeMkekGi 31 
                 ++n+lI+++ +  ++ + ++++ eM+++G+
  EFC35636.1 550 VWNCLIQAHIQTKEVPKSIKIITEMQDCGV 579
                 7**************************997 PP

  == domain 15  score: 7.0 bits;  conditional E-value: 0.0094
         PPR   2 tynslIsgycknGkleeAlelfk 24 
                 t+n+l+ +++ + ++ee + ++k
  EFC35636.1 585 TFNILLTACADSKLFEEGKAIHK 607
                 9****************988765 PP

  == domain 16  score: 0.3 bits;  conditional E-value: 1.2
         PPR   2 tynslIsgyck 12 
                 ++n+lI+++ +
  EFC35636.1 655 IWNCLIQAHIQ 665
                 6******9865 PP

  == domain 17  score: 3.9 bits;  conditional E-value: 0.091
         PPR  17 eeAlelfkeMke 28 
                  +A+ +f+eMke
  EFC35636.1 681 NKAMVVFNEMKE 692
                 69*********8 PP

  == domain 18  score: -1.7 bits;  conditional E-value: 5.6
         PPR   2 tynslIsgycknGkleeAlelfkeMkekG 30 
                 ty +l+ g++     ++ l++++e+k kG
  EFC35636.1 700 TYLILLAGCGEYFARKMGLDIIDELKLKG 728
                 88888888876554555666666666555 PP

  == domain 19  score: 30.1 bits;  conditional E-value: 3.9e-10
         PPR   1 vtynslIsgycknGkleeAlelfkeMkekGi 31 
                 +tyn ++s+y+++Gk   A+ lf+eM+ k++
  EFC35636.1 771 ITYNNMLSCYAQHGKGTQAMNLFNEMVAKNV 801
                 69************************99875 PP

  == domain 20  score: 20.2 bits;  conditional E-value: 5.7e-07
         PPR   2 tynslIsgycknGkleeAlelfkeMkek 29 
                 t++++++ ++++G+++eA +l+ eMk k
  EFC35636.1 807 TFTIMLNTFSHCGMIDEANQLYGEMKTK 834
                 8************************975 PP

  == domain 21  score: 10.5 bits;  conditional E-value: 0.00067
         PPR   5 slIsgycknGkleeAlelfke 25 
                 +++++++++G+++eA+++++e
  EFC35636.1 846 VMVDVFARSGRFHEAEKIINE 866
                 69****************987 PP

  == domain 22  score: 15.2 bits;  conditional E-value: 2.2e-05
         PPR   2 tynslIsgycknGkleeAlelfkeMkekGi 31 
                  +++l+ g+ k +++e+A  + + M+e+Gi
  EFC35636.1 872 LWSALMAGCRKFNNVEKADNIRQLMIENGI 901
                 5***************************97 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.1   2.8e-07   0.00024      14      59 ..       2      47 ..       1      51 [. 0.94
   2 !   14.5   0.2   3.3e-05     0.028       2      46 ..      25      69 ..      25      82 .. 0.90
   3 !   35.8   0.1   7.4e-12   6.4e-09      14      62 ..     105     153 ..      87     154 .. 0.93
   4 !   33.3   0.3   4.4e-11   3.7e-08       4      61 ..     201     257 ..     198     258 .. 0.94
   5 !   18.4   0.0   1.9e-06    0.0016      32      62 ..     306     336 ..     300     337 .. 0.91
   6 !   37.4   0.1   2.3e-12     2e-09       6      62 ..     385     440 ..     382     441 .. 0.90
   7 !    7.2   0.0    0.0063       5.4      39      60 ..     467     488 ..     459     491 .. 0.71
   8 !   29.8   0.0   5.4e-10   4.6e-07       4      62 ..     537     595 ..     536     596 .. 0.96
   9 !    9.7   0.1     0.001      0.88      32      62 ..     681     710 ..     641     711 .. 0.83
  10 !   12.9   0.1    0.0001     0.086      12      41 ..     767     796 ..     755     796 .. 0.93
  11 !   15.9   0.4   1.2e-05      0.01       2      44 ..     792     834 ..     791     851 .. 0.91
  12 ?   -0.3   0.0       1.3   1.1e+03      18      47 ..     873     902 ..     862     909 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 2.8e-07
       PPR_3 14 dvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgv 59
                +v  Yth ++ ++ + ++++al ++  mk k i+P+   y  +l++
  EFC35636.1  2 NVFLYTHFINNCIWNDDLERALAIVLNMKGKDIEPNYAIYIPLLKA 47
                9999*********************************999888886 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 3.3e-05
       PPR_3  2 ilremerkgikldvvtYthLLtayanagnkklalevlermkkkgi 46
                i+ +m+ k+i+++   Y+ LL+a+ + +n +  +   + +kk  +
  EFC35636.1 25 IVLNMKGKDIEPNYAIYIPLLKAATVKKNIQVGMTLYQLVKKSNL 69
                5679************************************99875 PP

  == domain 3  score: 35.8 bits;  conditional E-value: 7.4e-12
       PPR_3  14 dvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvigg 62 
                  ++t+++L++ay++  n k a  v+ +mk +gi P   t+N+++ ++ +
  EFC35636.1 105 TIITWNSLIQAYIQENNIKKAIDVIHEMKDNGICPDSATFNILITACAN 153
                 699*******************************************975 PP

  == domain 4  score: 33.3 bits;  conditional E-value: 4.4e-11
       PPR_3   4 remerkgikldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvig 61 
                 ++m+ kg+ ++vv +t L +ay++  + + a  ++ +mk+ +++P+  t++++l ++ 
  EFC35636.1 201 EKMKSKGL-MNVVSFTCLVEAYIQINEIQKAIDTVTEMKQFKVTPNATTFSILLTACA 257
                 67888898.7**********************************************95 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 1.9e-06
       PPR_3  32 klalevlermkkkgikPtvvtyNailgvigg 62 
                 + a e++ +m+  g++P+  t+N++l ++ +
  EFC35636.1 306 RQAIEIITEMQDYGVEPNSTTFNILLTACAD 336
                 5799************************965 PP

  == domain 6  score: 37.4 bits;  conditional E-value: 2.3e-12
       PPR_3   6 merkgikldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvigg 62 
                 ++ kg+  ++v ++ L++ay+++++ + a ev+ +m+  gi+P+  t+N++l+++ +
  EFC35636.1 385 LKSKGLMNNIV-WNCLIQAYIQNKEVRQAIEVITEMQDYGIEPNSTTFNILLKACAD 440
                 66777776765.8******************************************65 PP

  == domain 7  score: 7.2 bits;  conditional E-value: 0.0063
       PPR_3  39 ermkkkgikPtvvtyNailgvi 60 
                 ++m++ g++P   ty +il+++
  EFC35636.1 467 NKMQQFGLNPDSTTYTIILKAC 488
                 5677777777777777777777 PP

  == domain 8  score: 29.8 bits;  conditional E-value: 5.4e-10
       PPR_3   4 remerkgikldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvigg 62 
                 ++++ kg+  +v  ++ L++a +++++     +++ +m+  g++P+  t+N++l ++ +
  EFC35636.1 537 EKLQSKGLMNNVAVWNCLIQAHIQTKEVPKSIKIITEMQDCGVEPNSTTFNILLTACAD 595
                 67899***************************************************965 PP

  == domain 9  score: 9.7 bits;  conditional E-value: 0.001
       PPR_3  32 klalevlermkkkgikPtvvtyNailgvigg 62 
                 + a+ v+++mk+ +i+P  +ty ++l  +g+
  EFC35636.1 681 NKAMVVFNEMKE-HIEPDKITYLILLAGCGE 710
                 57999*****86.9***********999985 PP

  == domain 10  score: 12.9 bits;  conditional E-value: 0.0001
       PPR_3  12 kldvvtYthLLtayanagnkklalevlerm 41 
                 +l+++tY+ +L+ ya+ g+   a++ +++m
  EFC35636.1 767 RLSIITYNNMLSCYAQHGKGTQAMNLFNEM 796
                 689*************************99 PP

  == domain 11  score: 15.9 bits;  conditional E-value: 1.2e-05
       PPR_3   2 ilremerkgikldvvtYthLLtayanagnkklalevlermkkk 44 
                 +++em++k+++++ +t+t +L+ +   g  + a++  ++mk k
  EFC35636.1 792 LFNEMVAKNVEMNENTFTIMLNTFSHCGMIDEANQLYGEMKTK 834
                 899**************************************76 PP

  == domain 12  score: -0.3 bits;  conditional E-value: 1.3
       PPR_3  18 YthLLtayanagnkklalevlermkkkgik 47 
                 + +L+ ++ +  n + a ++ + m ++gik
  EFC35636.1 873 WSALMAGCRKFNNVEKADNIRQLMIENGIK 902
                 678999999999****************98 PP

>> PPR_1  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.4e-06    0.0029       6      34 .]     105     133 ..     104     133 .. 0.95
   2 !   11.6   0.1   0.00021      0.18       1      16 [.     135     150 ..     135     152 .. 0.91
   3 ?   -2.7   0.0       6.1   5.2e+03      11      33 ..     181     203 ..     180     204 .. 0.84
   4 !    7.4   0.1    0.0042       3.5       6      34 .]     210     238 ..     206     238 .. 0.93
   5 ?    2.2   0.0      0.17   1.5e+02       3      16 ..     242     255 ..     240     259 .. 0.84
   6 ?   -2.4   0.0       4.9   4.2e+03      11      30 ..     286     305 ..     286     309 .. 0.83
   7 !    7.6   0.1    0.0036       3.1       2      15 ..     319     332 ..     318     335 .. 0.89
   8 !   10.4   0.0   0.00048      0.41       6      34 .]     392     420 ..     388     420 .. 0.93
   9 !    9.0   0.0    0.0013       1.1       2      16 ..     423     437 ..     422     441 .. 0.91
  10 !    6.7   0.1     0.007         6       2      16 ..     473     487 ..     472     488 .. 0.89
  11 ?   -0.3   0.0         1   8.7e+02       1      16 [.     542     557 ..     542     558 .. 0.84
  12 !    7.7   0.1    0.0033       2.8       2      15 ..     578     591 ..     577     594 .. 0.89
  13 ?    0.4   0.0      0.65   5.6e+02       1      16 [.     647     662 ..     647     663 .. 0.85
  14 ?    3.3   0.3     0.079        67      23      34 .]     680     691 ..     680     691 .. 0.92
  15 ?    2.8   0.0      0.12        99       2      16 ..     693     707 ..     692     709 .. 0.85
  16 !   16.8   0.1   4.8e-06    0.0041       7      34 .]     770     797 ..     767     797 .. 0.95
  17 !   16.8   0.5   4.7e-06     0.004       1      34 []     799     832 ..     799     832 .. 0.95
  18 ?    5.2   0.0      0.02        17      13      32 ..     847     866 ..     837     866 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.4e-06
                 -HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   6 dvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 +++T+N+LI ++ +++++++A+++  eM+
  EFC35636.1 105 TIITWNSLIQAYIQENNIKKAIDVIHEMK 133
                 579*************************7 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00021
                 SS----HHHHHHHHHH CS
       PPR_1   1 kGlkPdvvTYNtLIdG 16 
                 +G++Pd  T+N+LI +
  EFC35636.1 135 NGICPDSATFNILITA 150
                 69************75 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 6.1
                 HHHHHHHHHTS-HHHHHHHHHHH CS
       PPR_1  11 NtLIdGlCkaGrvdeAfelfdeM 33 
                 +++I+ + k+G+ + A+   ++M
  EFC35636.1 181 TSIINFYTKCGHPEIAINECEKM 203
                 78999999999999998877777 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.0042
                 -HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   6 dvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 +vv++++L+ ++ + +++ +A++ + eM+
  EFC35636.1 210 NVVSFTCLVEAYIQINEIQKAIDTVTEMK 238
                 9*************************996 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.17
                 ----HHHHHHHHHH CS
       PPR_1   3 lkPdvvTYNtLIdG 16 
                 + P++ T+++L+ +
  EFC35636.1 242 VTPNATTFSILLTA 255
                 78*********866 PP

  == domain 6  score: -2.4 bits;  conditional E-value: 4.9
                 HHHHHHHHHTS-HHHHHHHH CS
       PPR_1  11 NtLIdGlCkaGrvdeAfelf 30 
                 +++I+ + k+G+ d A+  f
  EFC35636.1 286 TSIINFYTKCGHPDIAINEF 305
                 68999999***999998755 PP

  == domain 7  score: 7.6 bits;  conditional E-value: 0.0036
                 S----HHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLId 15 
                 G++P+  T+N+L+ 
  EFC35636.1 319 GVEPNSTTFNILLT 332
                 99**********85 PP

  == domain 8  score: 10.4 bits;  conditional E-value: 0.00048
                 -HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   6 dvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 + + +N+LI ++ ++ +v  A+e+  eM+
  EFC35636.1 392 NNIVWNCLIQAYIQNKEVRQAIEVITEMQ 420
                 8999************************5 PP

  == domain 9  score: 9.0 bits;  conditional E-value: 0.0013
                 S----HHHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLIdG 16 
                 G++P+  T+N+L+++
  EFC35636.1 423 GIEPNSTTFNILLKA 437
                 9***********986 PP

  == domain 10  score: 6.7 bits;  conditional E-value: 0.007
                 S----HHHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLIdG 16 
                 Gl+Pd  TY++++++
  EFC35636.1 473 GLNPDSTTYTIILKA 487
                 9**********9876 PP

  == domain 11  score: -0.3 bits;  conditional E-value: 1
                 SS----HHHHHHHHHH CS
       PPR_1   1 kGlkPdvvTYNtLIdG 16 
                 kGl  +v  +N+LI +
  EFC35636.1 542 KGLMNNVAVWNCLIQA 557
                 5777899*******86 PP

  == domain 12  score: 7.7 bits;  conditional E-value: 0.0033
                 S----HHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLId 15 
                 G++P+  T+N+L+ 
  EFC35636.1 578 GVEPNSTTFNILLT 591
                 99**********85 PP

  == domain 13  score: 0.4 bits;  conditional E-value: 0.65
                 SS----HHHHHHHHHH CS
       PPR_1   1 kGlkPdvvTYNtLIdG 16 
                 kGl  dv  +N+LI +
  EFC35636.1 647 KGLMNDVAIWNCLIQA 662
                 577889********86 PP

  == domain 14  score: 3.3 bits;  conditional E-value: 0.079
                 HHHHHHHHHHHH CS
       PPR_1  23 vdeAfelfdeMe 34 
                 +++A+ +f+eM+
  EFC35636.1 680 LNKAMVVFNEMK 691
                 689********7 PP

  == domain 15  score: 2.8 bits;  conditional E-value: 0.12
                 S----HHHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLIdG 16 
                  ++Pd +TY +L+ G
  EFC35636.1 693 HIEPDKITYLILLAG 707
                 589******999877 PP

  == domain 16  score: 16.8 bits;  conditional E-value: 4.8e-06
                 HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   7 vvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 ++TYN +++++ ++G+   A+ lf+eM+
  EFC35636.1 770 IITYNNMLSCYAQHGKGTQAMNLFNEMV 797
                 79*************************6 PP

  == domain 17  score: 16.8 bits;  conditional E-value: 4.7e-06
                 SS----HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   1 kGlkPdvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 k+++ +  T++++++ +  +G++deA +l  eM+
  EFC35636.1 799 KNVEMNENTFTIMLNTFSHCGMIDEANQLYGEMK 832
                 57899****************************7 PP

  == domain 18  score: 5.2 bits;  conditional E-value: 0.02
                 HHHHHHHTS-HHHHHHHHHH CS
       PPR_1  13 LIdGlCkaGrvdeAfelfde 32 
                 ++d + + Gr +eA+++ +e
  EFC35636.1 847 MVDVFARSGRFHEAEKIINE 866
                 7899************9876 PP

>> PPR_long  Pentacotripeptide-repeat region of PRORP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.0   1.2e-07   0.00011      15     173 ..       7     154 ..       4     172 .. 0.83
   2 !   26.0   0.1   6.1e-09   5.2e-06      23     173 ..     118     259 ..     113     276 .. 0.85
   3 !   25.5   0.0   8.5e-09   7.2e-06      27     174 ..     305     442 ..     293     462 .. 0.88
   4 !   12.1   0.0   0.00011     0.093      72     173 ..     495     596 ..     462     609 .. 0.81
   5 !   23.8   0.7   2.9e-08   2.5e-05      70     180 ..     713     828 ..     637     846 .. 0.83
   6 !   15.6   0.0   9.2e-06    0.0079      24     120 ..     783     871 ..     781     902 .. 0.72

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 1.2e-07
                 HHHHHHHHHHT-HHHHHHHHHHHHHSSS---HHHHHHHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHH CS
    PPR_long  15 rrqldkCskekDaaaAlelydkavaegvrlaqyhynvllylcskaeaaseskknkalargfevfeamkakgvspnEatvtalarlaaakedgdlafelv 113
                  + +++C  + D+++Al++  +++ ++++ +  +y   + l+ +a+     k  k ++ g+  ++ +k+++ ++     t+++  a + +  +l  e +
  EFC35636.1   7 THFINNCIWNDDLERALAIVLNMKGKDIEPNYAIY---IPLLKAATV----K--KNIQVGMTLYQLVKKSNLASP-QLSTTIISFALKLRKPELVIEEI 95 
                 56799***********************8775555...566644432....2..35999*****99999887665.56788999999999999888877 PP

                 HHHHHH-S---HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHHHHHHHHT CS
    PPR_long 114 kemekagvsPrLRsyaPaLaayckagdadkaleveehlkasgveleEaelaaLLkvsaka 173
                 + +++++    + +++ +++ay + ++++ka+ v + +k  g+ ++ a ++ L+ ++a++
  EFC35636.1  96 ELVKQQKWM-TIITWNSLIQAYIQENNIKKAIDVIHEMKDNGICPDSATFNILITACANT 154
                 766666655.577*****************************************999976 PP

  == domain 2  score: 26.0 bits;  conditional E-value: 6.1e-09
                 HHT-HHHHHHHHHHHHHSSS---HHHHHHHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S CS
    PPR_long  23 kekDaaaAlelydkavaegvrlaqyhynvllylcskaeaaseskknkalargfevfeamkakgvspnEatvtalarlaaakedgdlafelvkemekagv 121
                 +e+ +++A+++  +++++g+   + ++n+l+  c++++  +e  k        ++ ++  ++  + +   +t+++   ++ +  + a +  ++m+++g+
  EFC35636.1 118 QENNIKKAIDVIHEMKDNGICPDSATFNILITACANTKLFAE-GK-----LIHKITTNTLKD--NCSVELLTSIINFYTKCGHPEIAINECEKMKSKGL 208
                 78999*****************************98854433.22.....223333333333..3334589**************************99 PP

                 ---HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHHHHHHHHT CS
    PPR_long 122 sPrLRsyaPaLaayckagdadkaleveehlkasgveleEaelaaLLkvsaka 173
                      s+  +  ay + ++++ka+     +k+ +v+++ + ++ LL ++ak 
  EFC35636.1 209 MN-VVSFTCLVEAYIQINEIQKAIDTVTEMKQFKVTPNATTFSILLTACAKL 259
                 85.77********************************************986 PP

  == domain 3  score: 25.5 bits;  conditional E-value: 8.5e-09
                 HHHHHHHHHHHHHSSS---HHHHHHHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S---H CS
    PPR_long  27 aaaAlelydkavaegvrlaqyhynvllylcskaeaaseskknkalargfevfeamkakgvspnEatvtalarlaaakedgdlafelvkemekagvsPrL 125
                  ++A+e+  ++ + gv+ ++ ++n+ll  c++++           ++g  + + ++ +  + +   +++++   ++ +  ++a +  ++++++g+   +
  EFC35636.1 305 FRQAIEIITEMQDYGVEPNSTTFNILLTACADSKLF---------EEGKAIHKLATGTLKDYSSELLASIVNFYTKCGHPETAIKECEQLKSKGLMNNI 394
                 679***************************888433.........45666677666666666667999****************************998 PP

                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHHHHHHHHTT CS
    PPR_long 126 RsyaPaLaayckagdadkaleveehlkasgveleEaelaaLLkvsakag 174
                   ++ +++ay + +++ +a+ev   ++  g+e++ + ++ LLk++a+  
  EFC35636.1 395 -VWNCLIQAYIQNKEVRQAIEVITEMQDYGIEPNSTTFNILLKACADSK 442
                 .79******************************************9865 PP

  == domain 4  score: 12.1 bits;  conditional E-value: 0.00011
                 HHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S---HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHHHHHH CS
    PPR_long  72 argfevfeamkakgvspnEatvtalarlaaakedgdlafelvkemekagvsPrLRsyaPaLaayckagdadkaleveehlkasgveleEaelaaLLkvs 170
                 ++g  + e++ ++  + +   +t+++   ++ +  + +    ++++++g+      ++ +++a+ +++++ k++++   ++  gve++ + ++ LL ++
  EFC35636.1 495 EEGKLIHEQAIENVKDCSTELLTSIISFYTKCGHPEVSIGECEKLQSKGLMNNVAVWNCLIQAHIQTKEVPKSIKIITEMQDCGVEPNSTTFNILLTAC 593
                 45556666666677777778899999999999999999999999999999999999****************************************999 PP

                 HHT CS
    PPR_long 171 aka 173
                 a+ 
  EFC35636.1 594 ADS 596
                 975 PP

  == domain 5  score: 23.8 bits;  conditional E-value: 2.9e-08
                 HHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S---HH..HHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHH CS
    PPR_long  70 alargfevfeamkakgvspnEatvtalarlaaakedgdlafelvkemekagvsPrLR..syaPaLaayckagdadkaleveehlkasgveleEaelaaL 166
                 a + g+ + +++k kg++  E +v+ ++   +  +   +a +l +++ +   + rL   +y+ +L +y + g+  +a++  + + a++ve++E+ ++ +
  EFC35636.1 713 ARKMGLDIIDELKLKGMDVHEEIVSVMIYFYSRIAYQSTAQQLFEKLVEESAQKRLSiiTYNNMLSCYAQHGKGTQAMNLFNEMVAKNVEMNENTFTIM 811
                 44679999***************************************9999999985559*************************************** PP

                 HHHHHHTT...-HHHHH CS
    PPR_long 167 Lkvsakag...redkvY 180
                 L+   ++g   +++++Y
  EFC35636.1 812 LNTFSHCGmidEANQLY 828
                 *9988877222455555 PP

  == domain 6  score: 15.6 bits;  conditional E-value: 9.2e-06
                 HT-HHHHHHHHHHHHHSSS---HHHHHHHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHH.TT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH- CS
    PPR_long  24 ekDaaaAlelydkavaegvrlaqyhynvllylcskaeaaseskknkalargfevfeamka.kgvspnEatvtalarlaaakedgdlafelvkemekag 120
                 ++  ++A++l++++va++v+++++++ ++l+  s+            ++++ + + +mk+  + +p+  +   ++ + a ++ + +a+++++e  ++ 
  EFC35636.1 783 HGKGTQAMNLFNEMVAKNVEMNENTFTIMLNTFSHCG---------MIDEANQLYGEMKTkYNHNPSVIVDCVMVDVFARSGRFHEAEKIINERMNYS 871
                 5666899999999999999999999999999998873.........3677788999998834556666666778889999999999999998855554 PP

>> DYW_deaminase  DYW family of nucleic acid deaminases
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       2.6   2.2e+03      11      47 ..     210     245 ..     201     250 .. 0.77
   2 !   91.9   0.6   3.3e-29   2.8e-26       5     127 .]     909    1031 ..     905    1031 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2.6
  DYW_deaminase  11 kvvkfasgdkahpeskeieekleelsqrllsigyapd 47 
                    +vv+f+   +a+++++ei+++++ ++ ++++  + p+
     EFC35636.1 210 NVVSFTCLVEAYIQINEIQKAIDTVT-EMKQFKVTPN 245
                    67889999999*******99997765.6777777665 PP

  == domain 2  score: 91.9 bits;  conditional E-value: 3.3e-29
  DYW_deaminase    5 lvegkkkvvkfasgdkahpeskeieekleelsqrllsigyapdlekalh.dvkeeekekkplllsHsEKlalaygllktesgaqiriiknlrvC 97  
                       e ++k ++f+sg k +   keie+  ee+ ++++++g++pd++ +   +   ee+ k + l++H+EK a a ++   +++  i+ + nlrvC
     EFC35636.1  909 YQEEDGKSYQFVSGSKKYERFKEIEKMREEIYRKIIQAGFEPDTRWVTNsKLLTEEE-KLDSLCRHAEKTATAHAFVLNPKRKSIILAANLRVC 1001
                     5677889**********************************9988777645544444.346********************************* PP

  DYW_deaminase   98 eDChsafkliskilkaeivvrdaerfrhfk 127 
                     +DCh+a+++isk+++ ei++rda+r +hfk
     EFC35636.1 1002 NDCHTATEFISKVMDVEIIIRDANRYHHFK 1031
                     *****************************7 PP

>> TUG-UBL1  TUG ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.1   4.9e-06    0.0042       8      41 ..     238     269 ..     231     284 .. 0.84
   2 ?    3.9   0.0     0.072        62      12      32 ..     320     340 ..     315     363 .. 0.81
   3 ?    5.5   0.0     0.024        20      12      42 ..     424     452 ..     420     460 .. 0.88
   4 !    8.2   0.0    0.0035         3       3      43 ..     465     503 ..     463     511 .. 0.88
   5 ?    5.5   0.0     0.024        21      10      40 ..     577     614 ..     573     625 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 4.9e-06
    TUG-UBL1   8 fkvkvtpnttlndvLeeackkfklddsasytLkh 41 
                 +++kvtpn t   +L +ac+k+kl +  ++ L h
  EFC35636.1 238 KQFKVTPNATTFSILLTACAKLKLYK--EGILIH 269
                 799*********************54..466666 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.072
    TUG-UBL1  12 vtpnttlndvLeeackkfkld 32 
                 v pn+t   +L +ac+  kl 
  EFC35636.1 320 VEPNSTTFNILLTACADSKLF 340
                 89**************99993 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.024
    TUG-UBL1  12 vtpnttlndvLeeackkfklddsasytLkhn 42 
                 + pn+t   +L +ac+  kl  + ++ L+h+
  EFC35636.1 424 IEPNSTTFNILLKACADSKL-FE-EGKLLHQ 452
                 68******************.77.8999987 PP

  == domain 4  score: 8.2 bits;  conditional E-value: 0.0035
    TUG-UBL1   3 ynfrrfkvkvtpnttlndvLeeackkfklddsasytLkhnn 43 
                  n++ +++ ++p +t  +++ +ac+ f+l  + ++ L h +
  EFC35636.1 465 LNNKMQQFGLNPDSTTYTIILKACTDFNL-FE-EGKLIHEQ 503
                 588889999********************.77.89998876 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.024
    TUG-UBL1  10 vkvtpnttlndvLeeackkfklddsa.......sytLk 40 
                 + v pn+t   +L +ac+  kl ++        ++tLk
  EFC35636.1 577 CGVEPNSTTFNILLTACADSKLFEEGkaihklaTGTLK 614
                 5699*****************94443466666666666 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.0     0.049        41      31      48 ..     112     129 ..     108     135 .. 0.87
   2 ?    3.3   0.0      0.14   1.2e+02      31      48 ..     217     234 ..     215     240 .. 0.90
   3 ?   -2.1   0.0       6.9   5.9e+03       7      25 ..     305     325 ..     300     365 .. 0.64
   4 ?    4.3   0.0      0.07        60      31      51 ..     399     419 ..     373     423 .. 0.76
   5 ?   -1.0   0.0         3   2.6e+03      23      49 ..     546     572 ..     541     576 .. 0.84
   6 ?    2.1   0.0      0.34   2.9e+02      10      51 ..     752     796 ..     750     802 .. 0.76
   7 !    9.0   0.0    0.0022       1.9       6      50 ..     820     866 ..     819     879 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.049
      TPR_19  31 LAeallalgqldeAealL 48 
                 L++a+++ +++++A++++
  EFC35636.1 112 LIQAYIQENNIKKAIDVI 129
                 89************9986 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.14
      TPR_19  31 LAeallalgqldeAealL 48 
                 L+ea+++ +++++A++++
  EFC35636.1 217 LVEAYIQINEIQKAIDTV 234
                 789***********9987 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 6.9
      TPR_19   7 yaeAlalleqalqe..dpkna 25 
                 + +A+++ +++ ++  +p++ 
  EFC35636.1 305 FRQAIEIITEMQDYgvEPNST 325
                 455666666653324455555 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.07
      TPR_19  31 LAeallalgqldeAealLdal 51 
                 L++a+++++++ +A++++ + 
  EFC35636.1 399 LIQAYIQNKEVRQAIEVITEM 419
                 89**************98765 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 3
      TPR_19  23 knaearllLAeallalgqldeAealLd 49 
                 +n +++  L++a+++++++ + ++++ 
  EFC35636.1 546 NNVAVWNCLIQAHIQTKEVPKSIKIIT 572
                 678888889*********999988875 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.34
      TPR_19  10 Alalleqalqedpknaearl...lLAeallalgqldeAealLdal 51 
                 A++l+e++ +e+++     +   ++  ++ + g  ++A++l ++ 
  EFC35636.1 752 AQQLFEKLVEESAQKRLSIItynNMLSCYAQHGKGTQAMNLFNEM 796
                 899999999999884444443447799999999999999998865 PP

  == domain 7  score: 9.0 bits;  conditional E-value: 0.0022
      TPR_19   6 dyaeAlalleqalqedpknaearl..lLAeallalgqldeAealLda 50 
                   +eA +l+ ++ +++++n+ +     ++++   +g++ eAe+++++
  EFC35636.1 820 MIDEANQLYGEMKTKYNHNPSVIVdcVMVDVFARSGRFHEAEKIINE 866
                 579*********************6666****************986 PP

>> MRP-S27  Mitochondrial 28S ribosomal protein S27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   0.0   0.00011     0.091     106     157 ..     108     159 ..      95     207 .. 0.80
   2 ?    1.4   0.1      0.13   1.1e+02     105     161 ..     214     268 ..     202     297 .. 0.77
   3 ?    1.3   0.0      0.14   1.2e+02     121     146 ..     306     331 ..     300     349 .. 0.86
   4 !   11.1   0.0   0.00015      0.13     109     146 ..     398     435 ..     387     446 .. 0.92
   5 ?   -1.5   0.0      0.99   8.5e+02     110     146 ..     554     590 ..     547     606 .. 0.86
   6 ?   -2.5   0.0         2   1.7e+03     116     161 ..     782     827 ..     768     843 .. 0.64
   7 ?   -1.9   0.0       1.4   1.2e+03     143     166 ..     845     868 ..     839     871 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00011
     MRP-S27 106 tshaliRqlLkygakdkaLkllknkvqyGiFpDdftanlllDsflkngdyks 157
                 t  +li+ +++ ++ +ka+ ++++  + Gi pD +t+n+l+     ++ +++
  EFC35636.1 108 TWNSLIQAYIQENNIKKAIDVIHEMKDNGICPDSATFNILITACANTKLFAE 159
                 55679***********************************976666665555 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.13
     MRP-S27 105 stshaliRqlLkygakdkaLkllknkvqyGiFpDdftanlllDsflkngdyksAvsv 161
                 +t   l+  +++ ++ +ka+ ++ +  q+ + p+  t+ +ll    k + yk+++ +
  EFC35636.1 214 FTC--LVEAYIQINEIQKAIDTVTEMKQFKVTPNATTFSILLTACAKLKLYKEGILI 268
                 444..8889999999999999999999999999999999999888888888887765 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.14
     MRP-S27 121 dkaLkllknkvqyGiFpDdftanlll 146
                  +a++++ +  +yG+ p+  t+n+ll
  EFC35636.1 306 RQAIEIITEMQDYGVEPNSTTFNILL 331
                 589999*******************8 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00015
     MRP-S27 109 aliRqlLkygakdkaLkllknkvqyGiFpDdftanlll 146
                  li+ +++++++ +a++++ +  +yGi p+  t+n+ll
  EFC35636.1 398 CLIQAYIQNKEVRQAIEVITEMQDYGIEPNSTTFNILL 435
                 5899********************************98 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 0.99
     MRP-S27 110 liRqlLkygakdkaLkllknkvqyGiFpDdftanlll 146
                 li+  ++ +++ k +k++ +  + G+ p+  t+n+ll
  EFC35636.1 554 LIQAHIQTKEVPKSIKIITEMQDCGVEPNSTTFNILL 590
                 677888899999999999999999**********998 PP

  == domain 6  score: -2.5 bits;  conditional E-value: 2
     MRP-S27 116 kygakdkaLkllknkvqyGiFpDdftanlllDsflkngdyksAvsv 161
                 ++g+  +a++l ++ v   + +++ t+ ++l +f + g + +A ++
  EFC35636.1 782 QHGKGTQAMNLFNEMVAKNVEMNENTFTIMLNTFSHCGMIDEANQL 827
                 5556666666666666666666666777777777666666666555 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 1.4
     MRP-S27 143 nlllDsflkngdyksAvsvvtelm 166
                 ++++D+f ++g +++A ++  e m
  EFC35636.1 845 CVMVDVFARSGRFHEAEKIINERM 868
                 89**************99988766 PP

>> ATP13  Mitochondrial ATPase expression
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       9.2   7.9e+03      67      99 ..      16      46 ..       8      61 .. 0.58
   2 ?    2.6   0.0      0.13   1.1e+02      59      79 ..     111     131 ..      97     135 .. 0.88
   3 ?    0.4   0.0      0.68   5.8e+02      53      78 ..     176     201 ..     142     206 .. 0.77
   4 ?    2.6   0.0      0.14   1.2e+02      60     104 ..     217     259 ..     210     270 .. 0.76
   5 ?    2.7   0.0      0.12   1.1e+02      53     105 ..     281     338 ..     263     348 .. 0.66
   6 ?    3.9   0.0     0.052        45      53      82 ..     358     387 ..     338     401 .. 0.82
   7 !    7.3   0.0    0.0046         4      60     105 ..     399     442 ..     395     451 .. 0.83
   8 ?    2.0   0.0      0.21   1.8e+02      48      99 ..     507     556 ..     490     570 .. 0.77
   9 ?    1.3   0.0      0.35     3e+02      53     110 ..     617     672 ..     594     678 .. 0.77
  10 ?    0.9   0.0      0.45   3.9e+02      51      85 ..     767     801 ..     736     827 .. 0.73
  11 ?   -1.4   0.0       2.5   2.1e+03      56      86 ..     807     837 ..     798     854 .. 0.85
  12 ?   -1.5   0.0       2.5   2.2e+03       5      26 ..     845     866 ..     841     891 .. 0.73

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 9.2
       ATP13 67 nneiesAlklvdkfskkYpeielkkefWeelle 99
                n+++e+Al +v ++  k  +ie +  +++ ll+
  EFC35636.1 16 NDDLERALAIVLNMKGK--DIEPNYAIYIPLLK 46
                66777777777555443..24444444444444 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.13
       ATP13  59 aivssfsynneiesAlklvdk 79 
                 +++++++++n+i++A++++ +
  EFC35636.1 111 SLIQAYIQENNIKKAIDVIHE 131
                 7899*************9986 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.68
       ATP13  53 tselLkaivssfsynneiesAlklvd 78 
                 + elL++i++ + ++++ e A++  +
  EFC35636.1 176 SVELLTSIINFYTKCGHPEIAINECE 201
                 789*************9999987655 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.14
       ATP13  60 ivssfsynneiesAlklvdkfskkYpeielkkefWeellewaiil 104
                 +v+++++ nei++A++ v+++ k+++ +  + + ++ ll  + +l
  EFC35636.1 217 LVEAYIQINEIQKAIDTVTEM-KQFK-VTPNATTFSILLTACAKL 259
                 799***************995.6677.555666666666666665 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.12
       ATP13  53 tselLkaivssfsyn.......neiesAlklvdkfskkYpeielkkefWeellewaiilt 105
                 + +lL++i++ + ++       ne+ +A+++++++ + Y+ +e + + ++ ll  +  + 
  EFC35636.1 281 SLKLLTSIINFYTKCghpdiaiNEFRQAIEIITEM-QDYG-VEPNSTTFNILLTACADSK 338
                 46788888888887733333325577778888775.4577.7777777777776666555 PP

  == domain 6  score: 3.9 bits;  conditional E-value: 0.052
       ATP13  53 tselLkaivssfsynneiesAlklvdkfsk 82 
                 +selL++iv+ + ++++ e+A+k  +++ +
  EFC35636.1 358 SSELLASIVNFYTKCGHPETAIKECEQLKS 387
                 79********************98777655 PP

  == domain 7  score: 7.3 bits;  conditional E-value: 0.0046
       ATP13  60 ivssfsynneiesAlklvdkfskkYpeielkkefWeellewaiilt 105
                 +++++++n+e+ +A+++++++ + Y+ ie + + ++ ll+ +  + 
  EFC35636.1 399 LIQAYIQNKEVRQAIEVITEM-QDYG-IEPNSTTFNILLKACADSK 442
                 589*****************6.57**.9989999999999887665 PP

  == domain 8  score: 2.0 bits;  conditional E-value: 0.21
       ATP13  48 splyPtselLkaivssfsynneiesAlklvdkfskkYpeielkkefWeelle 99 
                 ++   ++elL++i+s + ++++ e  +   +k+++k     ++  +W+ l++
  EFC35636.1 507 NVKDCSTELLTSIISFYTKCGHPEVSIGECEKLQSKGL--MNNVAVWNCLIQ 556
                 55566899*************99999988888888744..557777777776 PP

  == domain 9  score: 1.3 bits;  conditional E-value: 0.35
       ATP13  53 tselLkaivssfsynneiesAlklvdkfskkYpeielkkefWeellewaiiltskked 110
                 +selL++iv+ + ++++ e  ++  +++ +k   + ++  +W+ l++  i +t+++++
  EFC35636.1 617 SSELLASIVNFYTKCGHPEVSIEECEQLKSKG--LMNDVAIWNCLIQAHIQSTTNTQN 672
                 799*************9999999888887764..466888888888877777766655 PP

  == domain 10  score: 0.9 bits;  conditional E-value: 0.45
       ATP13  51 yPtselLkaivssfsynneiesAlklvdkfskkYp 85 
                 + +  +  +++s+++++++  +A++l ++++ k  
  EFC35636.1 767 RLSIITYNNMLSCYAQHGKGTQAMNLFNEMVAKNV 801
                 555556678999***************99988744 PP

  == domain 11  score: -1.4 bits;  conditional E-value: 2.5
       ATP13  56 lLkaivssfsynneiesAlklvdkfskkYpe 86 
                 + + +++ fs+++ i++A +l  ++ +kY++
  EFC35636.1 807 TFTIMLNTFSHCGMIDEANQLYGEMKTKYNH 837
                 56667899****************9999996 PP

  == domain 12  score: -1.5 bits;  conditional E-value: 2.5
       ATP13   5 stvilslgrsgqlelieklikk 26 
                 + ++  ++rsg+ ++ ek+i++
  EFC35636.1 845 CVMVDVFARSGRFHEAEKIINE 866
                 5666678888888888888875 PP

>> PHB_acc  PHB accumulation regulatory domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.053        45       2      14 ..     176     188 ..     176     189 .. 0.91
   2 ?    1.4   0.0       0.4   3.4e+02       4      14 ..     283     293 ..     281     294 .. 0.86
   3 ?    1.6   0.0      0.34   2.9e+02       2      14 ..     358     370 ..     358     371 .. 0.90
   4 ?    3.9   0.0     0.066        56       2      14 ..     512     524 ..     512     525 .. 0.92
   5 ?    1.6   0.0      0.34   2.9e+02       2      14 ..     617     629 ..     617     630 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.053
     PHB_acc   2 ptefLaqlIrfYg 14 
                 ++e+L+ +I+fY 
  EFC35636.1 176 SVELLTSIINFYT 188
                 689*********6 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.4
     PHB_acc   4 efLaqlIrfYg 14 
                  +L+ +I+fY 
  EFC35636.1 283 KLLTSIINFYT 293
                 68********6 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.34
     PHB_acc   2 ptefLaqlIrfYg 14 
                 ++e+La +++fY 
  EFC35636.1 358 SSELLASIVNFYT 370
                 689*********6 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.066
     PHB_acc   2 ptefLaqlIrfYg 14 
                 +te+L+ +I+fY 
  EFC35636.1 512 STELLTSIISFYT 524
                 79**********6 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.34
     PHB_acc   2 ptefLaqlIrfYg 14 
                 ++e+La +++fY 
  EFC35636.1 617 SSELLASIVNFYT 629
                 689*********6 PP

>> ECSIT  Evolutionarily conserved signalling intermediate in Toll pathway
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0    0.0034       2.9     118     143 ..     124     149 ..      95     157 .. 0.79
   2 ?   -0.9   0.0      0.83   7.1e+02     118     143 ..     229     254 ..     218     260 .. 0.84
   3 ?    2.8   0.0     0.062        53     119     143 ..     308     332 ..     303     339 .. 0.84
   4 ?    4.4   0.0     0.021        18     112     143 ..     403     436 ..     386     442 .. 0.77
   5 ?    1.5   0.0      0.16   1.3e+02     119     143 ..     567     591 ..     542     597 .. 0.85
   6 ?   -3.3   0.0       4.7     4e+03     116     143 ..     634     661 ..     618     672 .. 0.72
   7 ?   -1.9   0.1       1.7   1.5e+03      32      58 ..     754     784 ..     746     820 .. 0.61

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0034
       ECSIT 118 cgvdvLeqmeengvlPdketeallvq 143
                  ++dv+++m++ng+ Pd+ t  +l+ 
  EFC35636.1 124 KAIDVIHEMKDNGICPDSATFNILIT 149
                 479***************99999986 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.83
       ECSIT 118 cgvdvLeqmeengvlPdketeallvq 143
                  ++d + +m+++ v P+  t ++l+ 
  EFC35636.1 229 KAIDTVTEMKQFKVTPNATTFSILLT 254
                 57899999*********999888875 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.062
       ECSIT 119 gvdvLeqmeengvlPdketeallvq 143
                 +++++ +m+++gv P++ t  +l+ 
  EFC35636.1 308 AIEIITEMQDYGVEPNSTTFNILLT 332
                 6899999999999999998888775 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.021
       ECSIT 112 yprqqec..gvdvLeqmeengvlPdketeallvq 143
                 y +++e+  +++v+ +m+++g+ P++ t  +l++
  EFC35636.1 403 YIQNKEVrqAIEVITEMQDYGIEPNSTTFNILLK 436
                 544444422799**************99999886 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.16
       ECSIT 119 gvdvLeqmeengvlPdketeallvq 143
                  ++++ +m+++gv P++ t  +l+ 
  EFC35636.1 567 SIKIITEMQDCGVEPNSTTFNILLT 591
                 699*************999888875 PP

  == domain 6  score: -3.3 bits;  conditional E-value: 4.7
       ECSIT 116 qecgvdvLeqmeengvlPdketeallvq 143
                  e+ ++  eq++++g++ d  +   l+q
  EFC35636.1 634 PEVSIEECEQLKSKGLMNDVAIWNCLIQ 661
                 4677777889999999988887777776 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 1.7
       ECSIT  32 elfekaagekkdka....tfleavevfekrs 58 
                 +lfek  +e+ +k+    t+++++++++++ 
  EFC35636.1 754 QLFEKLVEESAQKRlsiiTYNNMLSCYAQHG 784
                 4455444444444333337777777777765 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0     0.017        15       3      22 ..     108     127 ..     106     130 .. 0.93
   2 ?   -1.9   0.0         4   3.5e+03      10      22 ..     220     232 ..     219     233 .. 0.89
   3 ?    4.1   0.0     0.053        45       5      30 ..     286     311 ..     283     312 .. 0.87
   4 ?   -2.1   0.0       4.7     4e+03      10      25 ..     368     383 ..     367     384 .. 0.83
   5 ?    3.1   0.0      0.11        91       3      22 ..     395     414 ..     394     418 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.017
                 HHHHHHHHHHHTT-HHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAle 22 
                 +++ l +ay + ++ ++A++
  EFC35636.1 108 TWNSLIQAYIQENNIKKAID 127
                 7*****************97 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 4
                 HHHHTT-HHHHHH CS
       TPR_1  10 ayfklgkydeAle 22 
                 ay + ++ ++A++
  EFC35636.1 220 AYIQINEIQKAID 232
                 89999******97 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.053
                 HHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekALel 30 
                   + n y k g +d A+  +++A+e+
  EFC35636.1 286 TSIINFYTKCGHPDIAINEFRQAIEI 311
                 566688******************98 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 4.7
                 HHHHTT-HHHHHHHHH CS
       TPR_1  10 ayfklgkydeAleyye 25 
                  y k g ++ A++ +e
  EFC35636.1 368 FYTKCGHPETAIKECE 383
                 599*********9776 PP

  == domain 5  score: 3.1 bits;  conditional E-value: 0.11
                 HHHHHHHHHHHTT-HHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAle 22 
                 +++ l +ay ++++  +A+e
  EFC35636.1 395 VWNCLIQAYIQNKEVRQAIE 414
                 79*****************8 PP

>> Ocnus  Janus/Ocnus family (Ocnus)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       7.4   6.3e+03      69     103 ..     117     151 ..     115     154 .. 0.86
   2 ?   -1.0   0.0       2.3     2e+03      43     104 ..     192     257 ..     166     260 .. 0.78
   3 ?    1.7   0.0      0.32   2.7e+02      66     105 ..     297     336 ..     270     338 .. 0.86
   4 ?    5.7   0.0     0.018        15      36     105 ..     368     440 ..     343     442 .. 0.76
   5 ?   -2.4   0.0       6.2   5.3e+03      81     106 ..     466     491 ..     459     492 .. 0.81
   6 ?   -0.1   0.0       1.2   9.9e+02      67     105 ..     557     595 ..     516     597 .. 0.83
   7 ?    1.5   0.1      0.38   3.2e+02       4      54 ..     892     939 ..     890     950 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 7.4
       Ocnus  69 iehdeekkkikvYGysqtfGkadheitaeilkkky 103
                 i+ ++ kk i v    +  G ++ + t +il +++
  EFC35636.1 117 IQENNIKKAIDVIHEMKDNGICPDSATFNILITAC 151
                 88899999999999999999999999999987665 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.3
       Ocnus  43 hadifekveeeleklg....levkclGGGriehdeekkkikvYGysqtfGkadheitaeilkkkyp 104
                 h +i+ + +e+++++g    ++ +cl   +i+++e +k i      ++f  +++++t +il ++++
  EFC35636.1 192 HPEIAINECEKMKSKGlmnvVSFTCLVEAYIQINEIQKAIDTVTEMKQFKVTPNATTFSILLTACA 257
                 777777888888887644445678999999999999999999999999999999999999887665 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.32
       Ocnus  66 GGriehdeekkkikvYGysqtfGkadheitaeilkkkypd 105
                    i ++e ++ i++    q +G  ++++t +il ++++d
  EFC35636.1 297 HPDIAINEFRQAIEIITEMQDYGVEPNSTTFNILLTACAD 336
                 55688999999**********************9988765 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.018
       Ocnus  36 glkkaeyhadifekveeeleklg....levkclGGGriehdeekkkikvYGysqtfGkadheitaeilkkkypd 105
                  ++k+  h + + k +e+l+++g    +  +cl   +i+++e ++ i+v    q +G  ++++t +il k+++d
  EFC35636.1 368 FYTKCG-HPETAIKECEQLKSKGlmnnIVWNCLIQAYIQNKEVRQAIEVITEMQDYGIEPNSTTFNILLKACAD 440
                 555554.5556666667777755222255678888899******************************998775 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 6.2
       Ocnus  81 YGysqtfGkadheitaeilkkkypdy 106
                   + q+fG  + ++t  i+ k+++d+
  EFC35636.1 466 NNKMQQFGLNPDSTTYTIILKACTDF 491
                 556799*************9999887 PP

  == domain 6  score: -0.1 bits;  conditional E-value: 1.2
       Ocnus  67 GriehdeekkkikvYGysqtfGkadheitaeilkkkypd 105
                   i+++e  k+ik+    q  G  ++++t +il ++++d
  EFC35636.1 557 AHIQTKEVPKSIKIITEMQDCGVEPNSTTFNILLTACAD 595
                 579999999**********************99988765 PP

  == domain 7  score: 1.5 bits;  conditional E-value: 0.38
       Ocnus   4 vpdvdideeGkfkYilikvkeeekeeekeivrglkkaeyhadifekveeel 54 
                 + +  i+ +G  k   i v++ee++++ ++v g kk+e  ++i  k++ee+
  EFC35636.1 892 IRQLMIE-NGIKKIPGI-VYQEEDGKSYQFVSGSKKYERFKEIE-KMREEI 939
                 5566666.666554444.55699999************999884.444444 PP

>> Katanin_con80  con80 domain of Katanin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0    0.0024         2      19      49 ..     112     142 ..     108     158 .. 0.87
   2 ?   -3.0   0.0       7.9   6.7e+03      20      44 ..     218     242 ..     216     253 .. 0.76
   3 ?   -2.2   0.0       4.3   3.6e+03      27      44 ..     303     320 ..     301     321 .. 0.89
   4 ?    3.5   0.0     0.077        66      20      44 ..     400     424 ..     396     426 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0024
  Katanin_con80  19 vvrtlweqndiksaveaivklqdqsvlvDvl 49 
                    +++++ ++n+ik+a+++i +++d++++ D  
     EFC35636.1 112 LIQAYIQENNIKKAIDVIHEMKDNGICPDSA 142
                    578899*******************998865 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 7.9
  Katanin_con80  20 vrtlweqndiksaveaivklqdqsv 44 
                    v ++ + n+i++a++++ +++   v
     EFC35636.1 218 VEAYIQINEIQKAIDTVTEMKQFKV 242
                    5566777888999999998887766 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 4.3
  Katanin_con80  27 ndiksaveaivklqdqsv 44 
                    n++++a+e i ++qd +v
     EFC35636.1 303 NEFRQAIEIITEMQDYGV 320
                    67899**********987 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.077
  Katanin_con80  20 vrtlweqndiksaveaivklqdqsv 44 
                    ++++ +++++++a+e+i ++qd ++
     EFC35636.1 400 IQAYIQNKEVRQAIEVITEMQDYGI 424
                    78899*****************975 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0       1.7   1.4e+03       9      22 ..     114     127 ..     109     129 .. 0.88
   2 ?    4.3   0.0     0.067        58      10      30 ..     291     311 ..     290     314 .. 0.92
   3 ?    1.5   0.0      0.54   4.6e+02       3      26 ..     361     384 ..     359     387 .. 0.85
   4 ?   -2.0   0.0       6.8   5.8e+03       9      24 ..     401     416 ..     401     418 .. 0.86
   5 ?   -1.7   0.0       5.5   4.7e+03       3      26 ..     620     643 ..     618     645 .. 0.83
   6 ?   -2.3   0.1       8.4   7.2e+03       4      25 ..     773     794 ..     772     795 .. 0.82
   7 ?   -2.1   0.0       7.6   6.5e+03      13      25 ..     853     865 ..     849     866 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 1.7
                 HHHHHTT-HHHHHH CS
       TPR_8   9 siylklgdyeeAke 22 
                 ++y++ +++++A+ 
  EFC35636.1 114 QAYIQENNIKKAID 127
                 79**********96 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.067
                 HHHHTT-HHHHHHHHHHHHHH CS
       TPR_8  10 iylklgdyeeAkeyyekalel 30 
                  y k g  + A+  +++a+e+
  EFC35636.1 291 FYTKCGHPDIAINEFRQAIEI 311
                 59999**************98 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.54
                 HHHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyek 26 
                 ++  + + y k g  e A++ +e+
  EFC35636.1 361 LLASIVNFYTKCGHPETAIKECEQ 384
                 66778899************9998 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 6.8
                 HHHHHTT-HHHHHHHH CS
       TPR_8   9 siylklgdyeeAkeyy 24 
                 ++y++ ++  +A+e++
  EFC35636.1 401 QAYIQNKEVRQAIEVI 416
                 689*********9976 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 5.5
                 HHHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyek 26 
                 ++  + + y k g  e ++e +e+
  EFC35636.1 620 LLASIVNFYTKCGHPEVSIEECEQ 643
                 6677788999******99999987 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 8.4
                 HHHHHHHHHHTT-HHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyye 25 
                 y+n+ s+y + g+  +A+  ++
  EFC35636.1 773 YNNMLSCYAQHGKGTQAMNLFN 794
                 9999999999998888887776 PP

  == domain 7  score: -2.1 bits;  conditional E-value: 7.6
                 HTT-HHHHHHHHH CS
       TPR_8  13 klgdyeeAkeyye 25 
                   g+++eA++ ++
  EFC35636.1 853 RSGRFHEAEKIIN 865
                 679******9876 PP

>> Uteroglobin  Uteroglobin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.99   8.5e+02      42      74 ..     415     448 ..     399     461 .. 0.72
   2 ?   11.0   0.1    0.0005      0.43      26      84 ..     449     508 ..     437     513 .. 0.90
   3 ?    1.6   0.2       0.4   3.4e+02      23      82 ..     752     813 ..     735     826 .. 0.63

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.99
                  HHHHHHTT---HHHHHHHHHHHHHHT.TS-HHHH CS
  Uteroglobin  42 YkeeLqkynpdpeaeealaelKqcvd.klsnetk 74 
                     e+q+y  +p+       lK c d kl +e k
   EFC35636.1 415 VITEMQDYGIEPNSTTFNILLKACADsKLFEEGK 448
                  5568899999999999999999999955554444 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.0005
                  HHHHHHHHHHHS-HHHHHHHHHTT---HHHHHHHHHHHHHHT.TS-HHHHHHHHHHHHHH CS
  Uteroglobin  26 aleevvekflegseeeYkeeLqkynpdpeaeealaelKqcvd.klsnetkenvaklleki 84 
                  +l ++  ++l++++ e+++++q++  +p+    +  lK c+d +l +e k   ++++e++
   EFC35636.1 449 LLHQASGQVLNNPTIELNNKMQQFGLNPDSTTYTIILKACTDfNLFEEGKLIHEQAIENV 508
                  67888889999**********************************999999888888776 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.4
                  --HHHHHHHHHHH..HS-HHHHHHHHHTT---HHHHHHHHHHHHHHTTS-HHHHHHHHHHHH CS
  Uteroglobin  23 gCpaleevvekfl..egseeeYkeeLqkynpdpeaeealaelKqcvdklsnetkenvaklle 82 
                  + +++e+ ve+      s   Y++ L+ y ++ +  +a+  + + v k  + + + ++ +l+
   EFC35636.1 752 AQQLFEKLVEESAqkRLSIITYNNMLSCYAQHGKGTQAMNLFNEMVAKNVEMNENTFTIMLN 813
                  55666666666664333666777777777777777777776666666655555555555544 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       1.8   1.5e+03      10      34 ..     289     313 ..     281     317 .. 0.68
   2 ?    6.8   0.1    0.0097       8.3      22      70 ..     752     795 ..     747     798 .. 0.81
   3 ?    0.5   0.0      0.89   7.6e+02      11      27 ..     849     865 ..     845     869 .. 0.65

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.8
      TPR_12  10 aavlrrlgrydeAlellekaleiar 34 
                  +++++ g  d A+  +++a+ei++
  EFC35636.1 289 INFYTKCGHPDIAINEFRQAIEIIT 313
                 5666777777777777777777764 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0097
      TPR_12  22 AlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlellee 70 
                 A++l+ek +e        ++ l ++t++n+  +y + g+  +A +l++e
  EFC35636.1 752 AQQLFEKLVEES-----AQKRLSIITYNNMLSCYAQHGKGTQAMNLFNE 795
                 555555553333.....677799************************98 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.89
      TPR_12  11 avlrrlgrydeAlelle 27 
                 +v +r gr++eA+++ +
  EFC35636.1 849 DVFARSGRFHEAEKIIN 865
                 45666677777776654 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0       1.9   1.6e+03       9      23 ..     114     128 ..     114     131 .. 0.86
   2 ?    4.1   0.0     0.073        62      11      30 ..     292     311 ..     290     312 .. 0.90
   3 ?   -2.1   0.0       6.8   5.8e+03      11      26 ..     369     384 ..     367     386 .. 0.85
   4 ?   -1.5   0.0       4.4   3.8e+03       9      24 ..     401     416 ..     395     419 .. 0.85
   5 ?   -2.1   0.0       6.9   5.9e+03      10      29 ..     779     798 ..     778     800 .. 0.85
   6 ?   -1.5   0.0       4.5   3.8e+03      11      22 ..     851     862 ..     849     866 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 1.9
       TPR_2   9 layyklgdyeeAlea 23 
                 +ay++ ++ ++A++ 
  EFC35636.1 114 QAYIQENNIKKAIDV 128
                 69**********986 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.073
       TPR_2  11 yyklgdyeeAleafekAlel 30 
                 y k g+++ A++ f++A+e+
  EFC35636.1 292 YTKCGHPDIAINEFRQAIEI 311
                 77889*************97 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 6.8
       TPR_2  11 yyklgdyeeAleafek 26 
                 y k g++e A++ +e+
  EFC35636.1 369 YTKCGHPETAIKECEQ 384
                 77889*******9998 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 4.4
       TPR_2   9 layyklgdyeeAleaf 24 
                 +ay+++++  +A+e  
  EFC35636.1 401 QAYIQNKEVRQAIEVI 416
                 69**********9975 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 6.9
       TPR_2  10 ayyklgdyeeAleafekAle 29 
                 +y++ g+  +A ++f++ ++
  EFC35636.1 779 CYAQHGKGTQAMNLFNEMVA 798
                 7999999999***9999776 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 4.5
       TPR_2  11 yyklgdyeeAle 22 
                  +++g++ eA++
  EFC35636.1 851 FARSGRFHEAEK 862
                 6799******98 PP

>> Nrap  Nrap protein domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.2     0.077        65      52     101 ..     115     165 ..      61     187 .. 0.79
   2 ?    0.0   0.0      0.92   7.8e+02      70      96 ..     317     343 ..     261     350 .. 0.78
   3 ?    5.3   0.1     0.022        19      53     103 ..     403     454 ..     383     504 .. 0.69
   4 ?   -0.5   0.0       1.3   1.1e+03      72      97 ..     578     603 ..     554     613 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.077
                 EEGGG-TT-EEEEEEE--.-.----GGGTEEEEEEEE--TTSS-GGGGSTT CS
        Nrap  52 eylngdelkpiLvirpkk.eaekkfskskfririipvapsdlfklsklsps 101
                 +y++++++k  + + ++  ++    +++ f+i i ++a+ +lf   kl  +
  EFC35636.1 115 AYIQENNIKKAIDVIHEMkDNGICPDSATFNILITACANTKLFAEGKLIHK 165
                 56777777777766665414444556677**************99999655 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.92
                 -.----GGGTEEEEEEEE--TTSS-GG CS
        Nrap  70 eaekkfskskfririipvapsdlfkls 96 
                 +   + +++ f+i + ++a+s+lf+  
  EFC35636.1 317 DYGVEPNSTTFNILLTACADSKLFEEG 343
                 4455677889*************9765 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.022
                 EGGG-TT-EEEEE.EE---.----GGGTEEEEEEEE--TTSS-GGGGSTTS- CS
        Nrap  53 ylngdelkpiLvi.rpkkeaekkfskskfririipvapsdlfklsklspskn 103
                 y++++e ++ + + +  ++   + +++ f+i + ++a+s+lf+  kl+ + +
  EFC35636.1 403 YIQNKEVRQAIEViTEMQDYGIEPNSTTFNILLKACADSKLFEEGKLLHQAS 454
                 5566666666654044445555677888**************9999987744 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 1.3
                 ----GGGTEEEEEEEE--TTSS-GGG CS
        Nrap  72 ekkfskskfririipvapsdlfklsk 97 
                   + +++ f+i + ++a+s+lf+  k
  EFC35636.1 578 GVEPNSTTFNILLTACADSKLFEEGK 603
                 55677899**************7655 PP

>> Clathrin  Region in Clathrin and VPS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.1     0.092        78      45      67 ..     109     132 ..      60     166 .. 0.69
   2 ?    6.4   0.7    0.0091       7.8       7      99 ..     177     275 ..     171     301 .. 0.72
   3 ?    7.3   0.5    0.0048       4.1      11      99 ..     363     457 ..     357     495 .. 0.76
   4 ?    3.6   0.9     0.063        54      13      99 ..     399     508 ..     397     564 .. 0.68
   5 ?    2.2   0.0      0.17   1.5e+02       9      66 ..     515     572 ..     507     607 .. 0.73
   6 ?   -2.4   0.0       4.6   3.9e+03     122     137 ..     650     665 ..     612     669 .. 0.72
   7 ?   -1.5   0.2       2.4     2e+03      40      52 ..     788     800 ..     747     839 .. 0.59
   8 ?   -1.9   0.0       3.1   2.7e+03      73     102 ..     860     889 ..     847     899 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.092
                 HHHHHHHHHHTT-HHHHHHTTS.S CS
    Clathrin  45 qtallelyakyddpqeleeflk.k 67 
                  ++l+++y+++++++++ +++  +
  EFC35636.1 109 WNSLIQAYIQENNIKKAIDVIHeM 132
                 455555555555555555555432 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0091
                 TS-CCCCHHHHHCTT-HHHHCHHHCCHHHCHTS--HHHHHHHHHHHHHTT-HHHHHHTTS.......S---S-TTHHHHHHHT-SSHHHHHHHHHTTXT CS
    Clathrin   7 pidlsrvvklfeeaglleelleyLekvlkedskenpalqtallelyakyddpqeleeflk.......knnnydlekvaklcekadlyeeavilykkine 98 
                  + l+++++ + + g++e ++   ek  +++  +n+  +t l+e+y++ +++q++ + ++       + n      ++  c k +ly+e ++++k  n+
  EFC35636.1 177 VELLTSIINFYTKCGHPEIAINECEKMKSKG-LMNVVSFTCLVEAYIQINEIQKAIDTVTemkqfkvTPNATTFSILLTACAKLKLYKEGILIHKIANN 274
                 5567788888888888888888888888544.477999999********99999999998544443333335556788999999999999999987666 PP

                 H CS
    Clathrin  99 f 99 
                 +
  EFC35636.1 275 T 275
                 5 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0048
                 CCCHHHHHCTT-HHHHCHHHCCHHHCHTS--HHHHHHHHHHHHHTT-HHHHHHTTS.......S---S-TTHHHHHHHT-SSHHHHHHHHHTTXTH CS
    Clathrin  11 srvvklfeeaglleelleyLekvlkedskenpalqtallelyakyddpqeleeflk.......knnnydlekvaklcekadlyeeavilykkinef 99 
                  ++v+ + + g++e +++  e++ +++  +n ++ + l+++y++++++  + e+++       + n+   + ++k c + +l+ee ++l+++ +++
  EFC35636.1 363 ASIVNFYTKCGHPETAIKECEQLKSKG-LMNNIVWNCLIQAYIQNKEVRQAIEVITemqdygiEPNSTTFNILLKACADSKLFEEGKLLHQASGQV 457
                 567777777777777777777777444.4779999**********777777777775444444666667778999999999999999999887765 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.063
                 CHHHHHCTT-HHHHCHHHCCHHHCHTS--HHHHHHHHHHHHHT.......................T-HHHHHHTTSS---S-TTHHHHHHHT-SSHHH CS
    Clathrin  13 vvklfeeaglleelleyLekvlkedskenpalqtallelyaky.......................ddpqeleeflkknnnydlekvaklcekadlyee 88 
                 +++++ +++  ++++e+  + ++ + + n+  ++ ll++ a++                          +++++f  + ++     ++k c +++l+ee
  EFC35636.1 399 LIQAYIQNKEVRQAIEVITEMQDYGIEPNSTTFNILLKACADSklfeegkllhqasgqvlnnptieL-NNKMQQFGLNPDSTTYTIILKACTDFNLFEE 496
                 6777777777777777777777777777777777777777777666666666666666666666642.2466666666666666666666666666666 PP

                 HHHHHHT.TXTH CS
    Clathrin  89 avilykk.inef 99 
                  ++++   i+++
  EFC35636.1 497 GKLIHEQaIENV 508
                 666665545555 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.17
                 -CCCCHHHHHCTT-HHHHCHHHCCHHHCHTS--HHHHHHHHHHHHHTT-HHHHHHTTS CS
    Clathrin   9 dlsrvvklfeeaglleelleyLekvlkedskenpalqtallelyakyddpqeleeflk 66 
                  l++++  + + g++e  +   ek+++++ ++n+a+ + l+++ ++++++ +  ++++
  EFC35636.1 515 LLTSIISFYTKCGHPEVSIGECEKLQSKGLMNNVAVWNCLIQAHIQTKEVPKSIKIIT 572
                 5677888888888888888888899988888999999999999999988777777776 PP

  == domain 6  score: -2.4 bits;  conditional E-value: 4.6
                 TXXSHHHHHHHHHHHS CS
    Clathrin 122 vsnpelwekllealld 137
                 +++ ++w++l++a ++
  EFC35636.1 650 MNDVAIWNCLIQAHIQ 665
                 5667777777777665 PP

  == domain 7  score: -1.5 bits;  conditional E-value: 2.4
                 --HHHHHHHHHHH CS
    Clathrin  40 enpalqtallely 52 
                 + ++l+++++  +
  EFC35636.1 788 QAMNLFNEMVAKN 800
                 2344444444444 PP

  == domain 8  score: -1.9 bits;  conditional E-value: 3.1
                 TTHHHHHHHT-SSHHHHHHHHHTTXTHSSH CS
    Clathrin  73 lekvaklcekadlyeeavilykkinefkka 102
                 +ek+++  +++ l+  ++   +k+n+++ka
  EFC35636.1 860 AEKIINERMNYSLWSALMAGCRKFNNVEKA 889
                 567777777788887777777778877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1041 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1039  (0.0579508); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              21  [number of targets reported over threshold]
# CPU time: 0.92u 0.34s 00:00:01.26 Elapsed: 00:00:00.53
# Mc/sec: 5861.89
//
Query:       EFC35637.1  [L=385]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-32  110.1 145.1    5.4e-06   26.7   8.1    9.5  9  EGF_2     EGF-like domain
  ------ inclusion threshold ------
      0.022   15.1   2.9      0.022   15.1   2.9   10.2 10  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5  11.9   7.7e-06     0.069       3      32 .]      39      66 ..      37      66 .. 0.81
   2 !   17.6  11.5   4.1e-07    0.0037       6      32 .]      80     105 ..      75     105 .. 0.87
   3 !   22.3  10.0   1.4e-08   0.00013       5      32 .]     119     145 ..     115     145 .. 0.90
   4 !   19.8   8.9   8.3e-08   0.00074       5      32 .]     158     184 ..     154     184 .. 0.90
   5 !   23.3  15.9   6.6e-09   5.9e-05       5      32 .]     195     221 ..     189     221 .. 0.87
   6 !   15.6   7.2   1.8e-06     0.016       4      32 .]     233     262 ..     230     262 .. 0.85
   7 !   26.7   8.1     6e-10   5.4e-06       5      32 .]     275     301 ..     270     301 .. 0.90
   8 !   15.8   9.5   1.5e-06     0.013       5      32 .]     315     342 ..     310     342 .. 0.86
   9 !    3.8   0.3    0.0082        74       6      15 ..     356     365 ..     352     368 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 7.7e-06
       EGF_2  3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                ++++ C+ghG+C  + G C C+sg+ G++C
  EFC35637.1 39 NNETVCNGHGQCQ-KDGSCLCSSGF-GDQC 66
                44889*******8.5799******7.6666 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 4.1e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g G C +    C+C++g++G +C
  EFC35637.1  80 NVCNGYGNCTSYD-TCSCNAGWSGQYC 105
                 68*******9444.8************ PP

  == domain 3  score: 22.3 bits;  conditional E-value: 1.4e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C +++ +C+C++g++G +C
  EFC35637.1 119 SSVCSGNGLCYASN-KCKCNDGWTGSNC 145
                 688*******9788.************* PP

  == domain 4  score: 19.8 bits;  conditional E-value: 8.3e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+ hGtC++    C C+  ++G++C
  EFC35637.1 158 ATVCSRHGTCNSDH-TCTCNGDWTGDNC 184
                 568********999.9************ PP

  == domain 5  score: 23.3 bits;  conditional E-value: 6.6e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +e C++hG+C++ +  C+C++g++G++C
  EFC35637.1 195 GESCSQHGSCISNN-TCQCNNGWFGADC 221
                 789*******9555.9************ PP

  == domain 6  score: 15.6 bits;  conditional E-value: 1.8e-06
       EGF_2   4 s.deiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+  +G+Cv++   C+C+  ++G  C
  EFC35637.1 233 DlQNVCNRgRGQCVDTD-LCSCNETWTGQLC 262
                 457889877****9777.9**********99 PP

  == domain 7  score: 26.7 bits;  conditional E-value: 6e-10
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+ hG+C+n+   C+C+ g++G +C
  EFC35637.1 275 ISVCSSHGQCINAD-TCHCNKGWFGSNC 301
                 578*******9888.8************ PP

  == domain 8  score: 15.8 bits;  conditional E-value: 1.5e-06
       EGF_2   5 deiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g +G+C+ ++  C C++++ G  C
  EFC35637.1 315 KNVCNGgNGQCIGTE-LCLCNQNWAGQFC 342
                 789**99*****666.7***********9 PP

  == domain 9  score: 3.8 bits;  conditional E-value: 0.0082
       EGF_2   6 eiCgghGtCv 15 
                 + C+ hG C 
  EFC35637.1 356 TVCSTHGNCT 365
                 67*******6 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   4.9   2.7e-05      0.24       4      28 ..      39      62 ..      37      65 .. 0.82
   2 ?    3.0   8.2     0.015   1.3e+02       4      31 ..      79     103 ..      71     104 .. 0.87
   3 ?    7.1   5.7   0.00078         7       4      32 .]     117     144 ..     111     144 .. 0.80
   4 ?   -3.5   0.9       1.5   1.4e+04      18      23 ..     146     151 ..     145     151 .. 0.69
   5 ?    9.1   5.3   0.00017       1.6       5      31 ..     158     182 ..     155     183 .. 0.83
   6 ?    8.9   5.5   0.00021       1.9       6      31 ..     198     219 ..     192     220 .. 0.88
   7 ?    4.0   1.9    0.0069        62       6      30 ..     238     259 ..     232     261 .. 0.79
   8 ?   15.1   2.9   2.4e-06     0.022       6      32 .]     278     300 ..     271     300 .. 0.90
   9 ?    0.5   3.4     0.086   7.7e+02       9      30 ..     322     339 ..     314     341 .. 0.76
  10 ?    1.0   0.1     0.061   5.5e+02       5      18 ..     356     370 ..     353     373 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.7e-05
                TT...STTT-EEEEETTTEEEEEECTTE CS
         EGF  4 np...CsngGtCvdtgrggytCiCpeGy 28
                n+   C+++G C   +  + +C C++G+
  EFC35637.1 39 NNetvCNGHGQC---Q-KDGSCLCSSGF 62
                55578*******...4.777*******9 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.015
                 TT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++ C++ G C ++     tC C  G++G 
  EFC35637.1  79 TNvCNGYGNCTSYD----TCSCNAGWSGQ 103
                 446*******9999....*********96 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.00078
                 TT...STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   4 np...CsngGtCvdtgrggytCiCpeGytGkr 32 
                 ++   Cs++G C      + +C+C  G+tG++
  EFC35637.1 117 YNssvCSGNGLCY----ASNKCKCNDGWTGSN 144
                 55566*******3....4558*********86 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 1.5
                 TEEEEE CS
         EGF  18 ggytCi 23 
                 ++ytC+
  EFC35637.1 146 DMYTCF 151
                 578885 PP

  == domain 5  score: 9.1 bits;  conditional E-value: 0.00017
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                    Cs +GtC    + ++tC+C   +tG+
  EFC35637.1 158 AtvCSRHGTC----NSDHTCTCNGDWTGD 182
                 246*******....9*******9888887 PP

  == domain 6  score: 8.9 bits;  conditional E-value: 0.00021
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G C+++     tC+C +G++G+
  EFC35637.1 198 CSQHGSCISNN----TCQCNNGWFGA 219
                 *******9999....*********96 PP

  == domain 7  score: 4.0 bits;  conditional E-value: 0.0069
                 STTT-E..EEEETTTEEEEEECTTEES CS
         EGF   6 CsngGt..CvdtgrggytCiCpeGytG 30 
                 C n+G+  Cvdt      C C e +tG
  EFC35637.1 238 C-NRGRgqCVDTD----LCSCNETWTG 259
                 7.777777*****....****988887 PP

  == domain 8  score: 15.1 bits;  conditional E-value: 2.4e-06
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs +G C++      tC+C  G++G++
  EFC35637.1 278 CSSHGQCINAD----TCHCNKGWFGSN 300
                 *******8888....**********86 PP

  == domain 9  score: 0.5 bits;  conditional E-value: 0.086
                 T-EEEEETTTEEEEEECTTEES CS
         EGF   9 gGtCvdtgrggytCiCpeGytG 30 
                 +G C+ t+     C C + ++G
  EFC35637.1 322 NGQCIGTE----LCLCNQNWAG 339
                 46686666....9******999 PP

  == domain 10  score: 1.0 bits;  conditional E-value: 0.061
                 T.STTT-EEEEETTT CS
         EGF   5 p.CsngGtCvdtgrg 18 
                 + Cs +G C d+g  
  EFC35637.1 356 TvCSTHGNCTDVGLV 370
                 45*******998855 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       692  (0.0385967); expected 358.6 (0.02)
Passed bias filter:                      153  (0.00853366); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.36s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2199.51
//
Query:       EFC35638.1  [L=257]
Description: hypothetical protein NAEGRDRAFT_54819 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   3.8e-100  335.4   0.1      2e-99  333.0   0.1    1.8  1  Actin            Actin
  ------ inclusion threshold ------
       0.17   10.4   0.0       0.37    9.3   0.0    1.5  2  Methyltransf_29  Putative S-adenosyl-L-methionine-dependent m


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  333.0   0.1  2.2e-103     2e-99     113     407 .]       1     257 []       1     257 [] 0.98

  Alignments for each domain:
  == domain 1  score: 333.0 bits;  conditional E-value: 2.2e-103
       Actin 113 alEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtprylikkkkvveaess 211
                 +++i+fE+f vpa+y+a +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G++Lt++l+++l ++                     
  EFC35638.1   1 MTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMER--------------------- 78 
                 689**************************************************************************8..................... PP

       Actin 212 aekeelekltesyktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleeekskllgisel 308
                          ++s++t++e+e++++iKe++c+++ d+e+  + +++sss eksYeLPDg++i++g+eRf++pE+LF+p+ ig+e a         g++e 
  EFC35638.1  79 ---------GYSFNTTAEREIVRDIKEKLCYIALDFEAemKVAAESSSVEKSYELPDGNVITVGNERFRCPEVLFQPNFIGMEAA---------GVHET 159
                 .........9**************************996666677799***********************************99.........***** PP

       Actin 309 ivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGssvverkck 407
                 ++++i +cd+d+r++L+ n+v++GG+++++g+ eR+ kel+++a++++k+k++ap+ erkys+WiGGSiLAsl+tfqq+w++k+EYe+ G+ +v+rkc+
  EFC35638.1 160 TFNSIGKCDIDIRKDLYGNVVLSGGTTMFEGIAERMTKELTAMAPASMKIKVVAPP-ERKYSVWIGGSILASLSTFQQMWITKEEYEDAGPGIVHRKCF 257
                 ********************************************************.*****************************************6 PP

>> Methyltransf_29  Putative S-adenosyl-L-methionine-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.0   4.2e-05      0.37     104     163 ..      17      80 ..       4     101 .. 0.88
   2 ?   -2.6   0.0      0.17   1.5e+03      87     112 ..     181     206 ..     177     212 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 4.2e-05
  Methyltransf_29 104 klaelipliaaggkvrtvlDvGCgvas....fgayllsrdvltlslapkDeheaqvqfaLeRgv 163
                       ++ +++l a+g ++ +vlD G gv+     + +y l + +l l la +D  +  +++ +eRg 
       EFC35638.1  17 AIQAVLSLYASGRTTGIVLDSGDGVSHtvpiYEGYALPHAILRLDLAGRDLTDYLMKILMERGY 80 
                      68999999999************9985444489*****************************95 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.17
  Methyltransf_29  87 fPgggtqfkkgadkYidklaelipli 112
                        gg t+f+  a++  ++l+ + p+ 
       EFC35638.1 181 LSGGTTMFEGIAERMTKELTAMAPAS 206
                      679999**999999999999998874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       453  (0.0252663); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1686.17
//
Query:       EFC35639.1  [L=242]
Description: hypothetical protein NAEGRDRAFT_54818, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.013   15.6   1.1      0.013   15.6   1.1    2.2  2  DUF2433     Protein of unknown function (DUF2433)
       0.06   13.0   0.2      0.098   12.3   0.2    1.3  1  Herpes_UL4  Herpesvirus UL4 family
       0.29   10.3  12.0      0.026   13.8   5.8    1.9  2  ISG65-75    Invariant surface glycoprotein
       0.83   10.2   5.7       0.49   10.9   1.8    2.2  2  MRFAP1      MORF4 family-associated protein1


Domain annotation for each model (and alignments):
>> DUF2433  Protein of unknown function (DUF2433)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.2      0.28   1.2e+03      18      47 ..      68      96 ..      53     119 .. 0.59
   2 ?   15.6   1.1     3e-06     0.013      18      84 ..     172     233 ..     161     239 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.28
     DUF2433 18 rsklakskakfaevwetvkkeveaaideaq 47
                +  lak k+  +++ e +++ v + ++e+q
  EFC35639.1 68 KVELAKYKQVVNKMNEMMREMV-QCLNENQ 96
                4444555555555555555544.3344333 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 3e-06
     DUF2433  18 rsklakskakfaevwetvkkeveaaideaqrklLenalevvekiPtiakeeakkneastskekeesa 84 
                 +skl    +k+++v+ t+k++ +a ++++++++ e++++ +e+iP+ ++++  ++++++++++++ a
  EFC35639.1 172 KSKL----TKYKNVFRTIKSKAKAKLEGENSNS-ESTVNEFEEIPKKKSKKGDNESKKKNEKNNSDA 233
                 4444....56889999******99999888777.788999*********888888888877777665 PP

>> Herpes_UL4  Herpesvirus UL4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.2   2.2e-05     0.098      16      73 ..      68     125 ..      59     141 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.2e-05
  Herpes_UL4  16 asalpdyeqvvysfeaGtRsiavkkkarrdrlpsgkvviqhtpvgtlivvDcetefca 73 
                 +  l +y+qvv  ++  +R ++   ++ +d +  + + iqh+  +++++   ++e+c 
  EFC35639.1  68 KVELAKYKQVVNKMNEMMREMVQCLNENQDIFQLSDLTIQHGDQVIVLTHKQRAEICE 125
                 556789**************************************************96 PP

>> ISG65-75  Invariant surface glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.4     0.084   3.8e+02      52     110 ..      33      90 ..      25     106 .. 0.66
   2 ?   13.8   5.8   5.7e-06     0.026      22     128 ..     119     231 ..     112     236 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.084
    ISG65-75  52 adyllketkdklayienakekvdyyvekleslleeakekgtltesdaeklkkaceeAka 110
                 ++   k+tkd+ + + n+ + +++y e +e+ l+  k +  ++++ ++k+++ ++e  +
  EFC35639.1  33 SKSSTKSTKDDSNILLNNPAFLKHYNEIVEENLRL-KVELAKYKQVVNKMNEMMREMVQ 90 
                 55666777777777777777788888777777776.55556666666666666655444 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 5.7e-06
    ISG65-75  22 qekadkkLnkeaakaL..C..alkkladkvreetadyllketkd.klayienakekvdyyvekleslleeakekgtltesdaeklkkaceeAka.knkk 114
                 q+   ++L+++ a++L  C  +lkk ++++ +++++ l k + + + ++ie +k+k+ +y++ ++ ++ +ak+k + ++s++e   +++ee  + k kk
  EFC35639.1 119 QRAEICELSEKTAQILhvCssILKKPITELDGSEKQLLFKIIFEcMGKSIERNKSKLTKYKNVFRTIKSKAKAKLEGENSNSESTVNEFEEIPKkKSKK 217
                 4455588888888886667445999999998888888888875526789************************************99999986548999 PP

    ISG65-75 115 arekakkalekaek 128
                  ++++kk++ek ++
  EFC35639.1 218 GDNESKKKNEKNNS 231
                 99999999999876 PP

>> MRFAP1  MORF4 family-associated protein1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1      0.23     1e+03      96     114 ..      75      93 ..      52      97 .. 0.67
   2 ?   10.9   1.8   0.00011      0.49      41      97 ..     167     223 ..     162     233 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.23
      MRFAP1  96 akeaarmgkrlvelvrrie 114
                  + + +m +++ e+v+ ++
  EFC35639.1  75 KQVVNKMNEMMREMVQCLN 93 
                 3446678888888777665 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00011
      MRFAP1  41 aylrarrklleidslldeikseveaseesaldparsPgaeaeervaklcakaerkak 97 
                 +  r+++kl   ++++  iks+  a+ e+   + +s  +e ee   k+++k ++ +k
  EFC35639.1 167 SIERNKSKLTKYKNVFRTIKSKAKAKLEGENSNSESTVNEFEEIPKKKSKKGDNESK 223
                 5679**********************9999999999999999988888887776554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (242 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2792  (0.155725); expected 358.6 (0.02)
Passed bias filter:                      629  (0.0350828); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.35s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 1399.21
//
Query:       EFC35640.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.7e-05   22.5   0.0    0.00012   21.9   0.0    1.2  1  Phage_integrase  Phage integrase family


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.0   6.8e-09   0.00012      35     169 ..      10     155 ..       2     157 .. 0.83

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 6.8e-09
                      --HHHHTT-BGGG.EECTTTEEEEE...........EEECSSSSEEEEECT...HHHHHHHHHHHHHHCHCCTTTSBSSBETTSSB--HHHHHH CS
  Phage_integrase  35 lRisEllsLrvkd.ldlengvilvh...........eregKgskeravpls...eealellkellskaleeaeksellfaskrgkplsrqtvrk 113
                      +R +El++L+++   +l+ng i+++           e+ ++  k    +l       ++ll +++++    ++ ++ lf  +++   ++++v++
       EFC35640.1  10 ARPGELARLKWGYvTKLRNGNIKLDlsghktdffllEKPITIDK----HLEnpsVCPVKLLFDYMDTVQHFKKADSPLFSLQDNIFFNTEDVSQ 99 
                      6999********97789999999984444444443333333333....3333335678999999999999999999****************** PP

                      HHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHHHHT-SSCCHHHHHHCC CS
  Phage_integrase 114 afkraveeagiekpltpHtlRhsfataLleagvdlrvvqkllGHssisttqiYthv 169
                       +k+a    + e  +++H+lR  + t+ + +g++++ + +   H+++++ q Y + 
       EFC35640.1 100 LIKNAMFYVDSEITVSGHSLRIGATTESIIKGIPTQDIIMGTRHKDVKSLQPYQRQ 155
                      ********999999*************************************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       317  (0.0176809); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.52
# Mc/sec: 1008.87
//
Query:       EFC35641.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.14   12.5   1.7       0.28   11.6   0.1    2.3  3  HCMV_UL139  Human Cytomegalovirus UL139 protein
        0.2   10.2  10.1       0.21   10.1   9.6    1.3  1  Macoilin    Macoilin family


Domain annotation for each model (and alignments):
>> HCMV_UL139  Human Cytomegalovirus UL139 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.54   4.9e+03      57      80 ..      31      54 ..      29      65 .. 0.69
   2 ?   11.6   0.1   3.1e-05      0.28      51     101 ..     118     168 ..     110     178 .. 0.89
   3 ?   -2.9   0.0      0.97   8.7e+03      37      62 ..     305     329 ..     302     336 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.54
  HCMV_UL139 57 dakyvaisrdlrslkgeveeaerk 80
                +a+++   ++lr+lk  ++ a+r 
  EFC35641.1 31 KARKQQAAKKLRKLKAMSPVANRN 54
                678888888888888765554443 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 3.1e-05
  HCMV_UL139  51 seidaldakyvaisrdlrslkgeveeaerkeeereryyeakrkemeeflpm 101
                  +i a++a+ + ++  lr++ g+++e+ +k +ere    + ++++e+ +p 
  EFC35641.1 118 HDIMAIKAQMQEMIGVLRTVTGNISELTKKVQEREEESDDDFVNPEAISPE 168
                 578899999999***********************9999999999998875 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 0.97
  HCMV_UL139  37 rkiadlnsrilslrseidaldakyva 62 
                 r i   ns  +++ se+ ++++ y+ 
  EFC35641.1 305 RYI-STNSFETAAESELHNIRTTYHY 329
                 555.4666667888888888888875 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   9.6   2.3e-05      0.21     235     362 ..       3     119 ..       1     338 [. 0.41

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 2.3e-05
    Macoilin 235 sknnhslnkkdsslklpeleyrekkksakssrsdskkkhehnesvdsklqekeymenkskskrl..........sksessgsesellveesvkskssss 323
                 +k+ ++ ++++s ++lp +e +  ++  k+++++++kk +       kl+ ++ ++n+ k k++              s+  +s+ll ++   ++ss++
  EFC35641.1   3 AKKPQDIDSSSSDEDLPAVEVEYPTTPVKARKQQAAKKLR-------KLKAMSPVANRNKRKQStsvsssnsalDDGISTVVSSSLLSNSTLLDSSSTA 94 
                 5666666666777777777666665555555444444433.......3333333333333333300000000002222233333333333333333333 PP

    Macoilin 324 ssssnknskkasagsagssnssskkhsessksvtsss.ss 362
                  sss               n+ss + s +++  +sss ++
  EFC35641.1  95 PSSS---------------NNSSSSNSGRDSFASSSSeHD 119
                 3332...............222222222222222211111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1493  (0.0832729); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2111.07
//
Query:       EFC35642.1  [L=169]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00015   22.0   0.0    0.00052   20.2   0.0    1.9  2  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0     0.082   1.5e+03      33      45 ..      21      36 ..      19      56 .. 0.68
   2 !   20.2   0.0   2.9e-08   0.00052      33     102 ..      78     168 ..      56     169 .] 0.73

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.082
                H-HHHHHHHTST...T CS
         BTB 33 rSpyFkalftsk...e 45
                 S+y+ ++f s    +
  EFC35642.1 21 MSNYLLNMFRSLnggS 36
                5999999999875541 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 2.9e-08
                 H-HHHHHHHTST...............TTTTCCCEEEEETTSGH...HHHHHHHHHHHHSEEEC-....CGGGHHHHHHHHHHHT-HHHHHH CS
         BTB  33 rSpyFkalftsk...............eieessvseielddvep...eafealLefiYtgeleit....seenleelLaaadllqiprlkka 102
                 rS   ++++++                + ++ s+ +iel++ ++   ++f+ +Le++Y ++l+i+    + ++l+++ ++a++l++p+l+++
  EFC35642.1  78 RSGLIRRMIEQSsdvaivdgkyvvdmtKVADISQ-QIELTEGTYlvrSDFDVVLEYLYGDNLNINgladDLGKLKKIVKLARYLDLPALMQE 168
                 5666666666666666666555555443344443.57777777744479********************999****************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       359  (0.0200234); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1066.46
//
Query:       EFC35643.1  [L=354]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-73  247.1   0.3    3.1e-71  239.3   0.3    2.2  1  Urocanase    Urocanase Rossmann-like domain
    1.9e-31  109.1   0.9      3e-31  108.4   0.0    1.8  2  Urocanase_C  Urocanase C-terminal domain
     0.0067   16.1   0.6      0.036   13.8   0.2    2.1  2  Urocanase_N  Urocanase N-terminal domain


Domain annotation for each model (and alignments):
>> Urocanase  Urocanase Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  239.3   0.3   5.2e-75   3.1e-71      30     210 .]      32     220 ..      21     220 .. 0.95

  Alignments for each domain:
  == domain 1  score: 239.3 bits;  conditional E-value: 5.2e-75
                 EEEEE--STTGGGHHHHHHHTT-EEEEEES-HHHHHHHHHTTS-SE.EES-HHHHHHHHHHHHHCT--EEEEEES-HHHHHHHHHCT.T---SEE---S CS
   Urocanase  30 lvvtaGlGgMsgaQplAatiagavalvvevdesriekrleqgyvde.vaddldealalikeakkekealsigllgnvvdvleelvee.gvlvdlvsdqt 126
                 +v+ aGlGgMsgaQp+A+ i+g++++v+ev+e +++kr+eqg++ e v +dl++++++ik+a+  k+++sig+lgn+v+++e+l++e ++lv+l+sdqt
  EFC35643.1  32 VVLNAGLGGMSGAQPKAGVISGCITVVAEVNELALKKRYEQGWLLEsVGNDLEKCIERIKQARLLKQVTSIGYLGNIVELWERLANEdELLVELGSDQT 130
                 6889***************************************8652789*************************************779********* PP

                 -TT-TTTS.---TT--HHHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHTT-EE-B-SS-HHHHHHHTT-T.....TGGGS-BHHHHT CS
   Urocanase 127 sahdplnG.YlPegltleeakelrkedpekfkeevkeslarhveailklqekGavvfdYGnnlrkeakeagvk.....eafkypsyvedi 210
                 s+h+p++G Y+P+glt+ee+++l+k++p++fk +v+esl+r+v+ai+kl ekG++++dYGn ++ ea++ag++     ++fkypsyv+di
  EFC35643.1 131 SLHNPYQGgYYPVGLTFEESNQLMKDNPNEFKLKVSESLKRQVNAINKLVEKGMKFWDYGNCFLYEANRAGADicnqdGNFKYPSYVQDI 220
                 *************************************************************************9987777********97 PP

>> Urocanase_C  Urocanase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.3      0.68   4.1e+03     130     153 ..      27      50 ..      24      68 .. 0.72
   2 !  108.4   0.0   5.1e-35     3e-31       1      89 [.     223     325 ..     223     327 .. 0.98

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.68
                  HT-SEEEEEESTTT-TTS-EEEEE CS
  Urocanase_C 130 rgatwvslhnGGgvgiGesinagf 153
                   g+t+v l  G g   G   +ag+
   EFC35643.1  27 HGTTLVVLNAGLGGMSGAQPKAGV 50 
                  688999999997777777666664 PP

  == domain 2  score: 108.4 bits;  conditional E-value: 5.1e-35
                  HHHTTT---EEEEETT--HHHHHHHHHHHHHHS..............TT-HHHHHHHHHHHHH----SS-EEE----TTHHHHHHHHHHHHHHHSSSS CS
  Urocanase_C   1 plFsegkGPFRwvalsgdpeDlaktdeavlell..............kekedlirWikeAeekvkvqGlpaRilyldaeeRekialafnelvregeik 84 
                  ++Fs g+GPFRwv+lsg+++Dl++td+++++++               +++d+++Wi +A e+++v+G++aRily+d e+R +ialafn+++reg+i+
   EFC35643.1 223 DIFSLGFGPFRWVCLSGNEKDLEETDKIAAQVIerlmknpslgekshLQYQDNYKWIVQAMENKLVVGSQARILYSDIEGRVEIALAFNKAIREGKIS 320
                  69*******************************************9999************************************************* PP

                  S-EEE CS
  Urocanase_C  85 apvvl 89 
                  ++++l
   EFC35643.1 321 GSIAL 325
                  **987 PP

>> Urocanase_N  Urocanase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.2     6e-06     0.036     111     127 .]       2      18 ..       1      18 [. 0.91
   2 ?   -0.1   0.0      0.11   6.8e+02      42      69 ..     103     130 ..      68     145 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 6e-06
                  HHTT---B-TTTTTTT- CS
  Urocanase_N 111 eakgltmyGqmtAgswi 127
                  +a+g t+yGqmtAgs++
   EFC35643.1   2 YALGNTIYGQMTAGSYC 18 
                  6899************7 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.11
                  TTTEESSSSHHHHHHHHHHHHH--TTEE CS
  Urocanase_N  42 ggtgkaarnweqfelivktLkeleedet 69 
                  g  g++++ we   +  + L el +d+t
   EFC35643.1 103 GYLGNIVELWERLANEDELLVELGSDQT 130
                  5566777777777777777777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       572  (0.0319036); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2153.38
//
Query:       EFC35644.1  [L=403]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (403 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2104  (0.117352); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 2247.34
//
Query:       EFC35645.1  [L=336]
Description: rabGTPase-activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    7.7e-44  149.9   3.8    1.3e-23   83.8   0.0    2.1  2  RabGAP-TBC  Rab-GTPase-TBC domain


Domain annotation for each model (and alignments):
>> RabGAP-TBC  Rab-GTPase-TBC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.8   0.0   7.1e-28   1.3e-23       3     125 ..      14     133 ..      12     138 .. 0.83
   2 !   66.0   1.8     2e-22   3.6e-18     117     215 .]     184     283 ..     172     283 .. 0.93

  Alignments for each domain:
  == domain 1  score: 83.8 bits;  conditional E-value: 7.1e-28
  RabGAP-TBC   3 lRgevWklllgyepevkrlkksekkqeksekeksklekseeskelsqIkkDvprtfp.es.esfknkqgqnqLeriLkaysiynpevgYcqGmndivap 99 
                 lR+++W   lg+e +     ++  k+++    ++  +++++ + +  I+ D++rtfp  + ++  +++  +  + iL +ys+ +p++gY+qGm++ va+
  EFC35645.1  14 LRSKMWVASLGNELQITPGLYEILKDKT----NQPSTMERQCSSIDLISVDLSRTFPaLQfFQYPDGPYYQPFKTILECYSKFRPDIGYVQGMSYMVAT 108
                 8***********8866666665555544....4455555555569************733588889999****************************** PP

  RabGAP-TBC 100 lllvsldeeeaFwcfvsLlekyklrd 125
                 ll +++de++aF cf++Ll++ k+++
  EFC35645.1 109 LL-LYMDEYDAFVCFCNLLHRSKCNS 133
                 **.999*************8777765 PP

  == domain 2  score: 66.0 bits;  conditional E-value: 2e-22
  RabGAP-TBC 117 Llekyklrdlytsslpglkrklkvleellkkkdpklykhl.keegldlelfaikwfltlflrefpletvlrlwD.lllegekfvllrvalailklleee 213
                 L +++++  ++t +++ + + +k ++ ll++++ +lykhl  ++g+++ +++i+wfltlf++++pl++v+r+wD +l++g   +++++++ il ++++e
  EFC35645.1 184 LYTSNHFIPFFTMNTDYIDKNVKFVRILLREHHAQLYKHLvVDLGVEFAVIIIDWFLTLFSKSLPLDVVARIWDgYLVHGR-LYMYSCTMGILIYYQKE 281
                 5567788899*****************************9799*******************************9999998.88999*********999 PP

  RabGAP-TBC 214 ll 215
                 ll
  EFC35645.1 282 LL 283
                 86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       705  (0.0393218); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.36s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 1886.60
//
Query:       EFC35646.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1237  (0.0689944); expected 358.6 (0.02)
Passed bias filter:                      757  (0.0422221); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 824.24
//
Query:       EFC35647.1  [L=302]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.4e-09   35.7   0.9    7.4e-09   35.7   0.9    2.1  2  HSP20     Hsp20/alpha crystallin family


Domain annotation for each model (and alignments):
>> HSP20  Hsp20/alpha crystallin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.25   4.4e+03      75      96 ..      62      83 ..      46      88 .. 0.64
   2 !   35.7   0.9   4.1e-13   7.4e-09      18     101 ..     221     301 ..     200     302 .] 0.79

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.25
                EEETTEEEEEEEBSS--..--- CS
       HSP20 75 slkdGvLtvtvpkkepekkkke 96
                s ++  L ++ +k+++ ++kk+
  EFC35647.1 62 SSSNPQLNIKTEKSKKLSRKKS 83
                4566667777777776655333 PP

  == domain 2  score: 35.7 bits;  conditional E-value: 4.1e-13
                 --CCCEEEEEETTEEEEEEE--..---TT----SS---EEEEEE--ST.TB-TTT-EEEE.ETTEEEEEEEBSS--...-------- CS
       HSP20  18 lkkeelkvkvednrvlvkgeheeeeedekglikerssrkFsrkftLPe.nvdadkvkasl.kdGvLtvtvpkkepekk.kkerkiqi 101
                 ++k++++vk+++n++    +   e+++e+g+ +      Fs++f+ P+  +d dkvka+l ++G L+v++p+  +++  + +++i+i
  EFC35647.1 221 FEKKDIEVKIKENSLGDLITISAEKKTENGHFQ------FSKSFRFPKgSLDLDKVKATLsDEGTLSVKIPRIDEPEIkERVKEISI 301
                 789**********96444444445678899999......*********558*********************776655488999988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1740  (0.0970495); expected 358.6 (0.02)
Passed bias filter:                      609  (0.0339673); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1823.07
//
Query:       EFC35648.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.04   13.9   0.2      0.097   12.7   0.2    1.6  1  DUF4911   Domain of unknown function (DUF4911)
        0.1   12.0   0.2       0.16   11.4   0.2    1.2  1  GP88      Gene product 88


Domain annotation for each model (and alignments):
>> DUF4911  Domain of unknown function (DUF4911)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2   1.1e-05     0.097      11      38 ..     256     283 ..     254     288 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.1e-05
     DUF4911  11 lkfIlEaydgLavvttvdkkkGlvrirt 38 
                 +k+I+E++  L v+t++d+++ ++ri +
  EFC35648.1 256 IKKIVESESELIVITQTDNRNEIMRIVV 283
                 89************************86 PP

>> GP88  Gene product 88
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2   1.8e-05      0.16      89     140 ..     388     439 ..     362     442 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 1.8e-05
        GP88  89 kwirvhdaGdffsdeyllaWlriiratPdtsfyaytkevsrfkrlvepdaPe 140
                 k+  + da +++ + y  + +  + ++ + + y + ++v+r++ l +++ Pe
  EFC35648.1 388 KYEWLDDAAEYYGQMYNVSRMLCMSSKDHENIYQWERDVERYRDLCHENMPE 439
                 455678*******************************************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       641  (0.0357521); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2806.78
//
Query:       EFC35649.1  [L=300]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.1e-17   61.1   2.9    3.8e-06   26.6   0.2    3.6  3  LRR_8       Leucine rich repeat
    9.8e-17   59.5   9.4     0.0052   16.7   0.0    7.9  8  LRR_6       Leucine Rich repeat
    1.1e-12   47.9  10.6     0.0048   17.3   0.1    6.3  7  LRR_4       Leucine Rich repeats (2 copies)
    0.00032   20.5   0.0    0.00074   19.4   0.0    1.6  1  F-box-like  F-box-like
     0.0074   16.7   6.7         13    6.8   0.0    6.4  7  LRR_1       Leucine Rich Repeat
  ------ inclusion threshold ------
       0.13   12.2   0.0       0.36   10.8   0.0    1.8  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   2.8e-05     0.084      22      61 .]     106     145 ..      95     145 .. 0.86
   2 !   26.6   0.2   1.3e-09   3.8e-06       2      58 ..     159     216 ..     158     219 .. 0.95
   3 !   20.3   0.3   1.2e-07   0.00036       3      58 ..     233     288 ..     231     291 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.8e-05
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  +l++L++L++    ++  + ++++ L++L+sL++sgN +
  EFC35649.1 106 GQLKQLTSLEIQGMDIDDEHVESMAELKQLTSLYISGNYI 145
                 5689999999999999999999999999999999999976 PP

  == domain 2  score: 26.6 bits;  conditional E-value: 1.3e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsg 58 
                 +Lt+L++s N++ +++ +  ++l++L++L++ +N ++       +sgL++L+ Ld+s+
  EFC35649.1 159 KLTKLNISANYIDNVGAKYISQLKQLTSLEIACNdSIGDAGIIYLSGLEHLTNLDISR 216
                 79********************************9999999999**********9985 PP

  == domain 3  score: 20.3 bits;  conditional E-value: 1.2e-07
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 Lt L+++  ++ +   ++ ++l++L vL++s+N+++   ++ +s L++L+sL++s 
  EFC35649.1 233 LTCLNINTCSIDDEVLQSISQLKKLIVLHISENEISIEGAKYISKLNQLTSLYISE 288
                 666666666666666678899********************************985 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.11   3.4e+02       4      18 ..     110     124 ..     107     130 .. 0.83
   2 !   10.4   0.0   0.00019      0.57       5      21 ..     135     151 ..     132     154 .. 0.92
   3 !   10.5   0.0   0.00018      0.53       4      24 .]     159     179 ..     158     179 .. 0.92
   4 !   16.7   0.0   1.8e-06    0.0052       4      24 .]     183     204 ..     180     204 .. 0.90
   5 !    6.8   0.0    0.0027         8       4      23 ..     208     227 ..     205     228 .. 0.89
   6 ?    4.3   0.1     0.016        49       5      18 ..     233     246 ..     231     252 .. 0.86
   7 !    7.4   0.0    0.0017       5.1       4      24 .]     256     276 ..     253     276 .. 0.88
   8 ?   -1.7   0.0       1.4   4.2e+03       3      14 ..     279     290 ..     277     292 .. 0.73

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.11
       LRR_6   4 hLteLdLsgNdIgDe 18 
                  Lt+L+++g dI+De
  EFC35649.1 110 QLTSLEIQGMDIDDE 124
                 59*******999998 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00019
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt+L +sgN Ig eG++
  EFC35649.1 135 LTSLYISGNYIGSEGVK 151
                 9**************97 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.00018
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L++s N I+++Ga+ ++
  EFC35649.1 159 KLTKLNISANYIDNVGAKYIS 179
                 8****************9885 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 1.8e-06
       LRR_6   4 hLteLdLsgNd.IgDeGaeaLa 24 
                  Lt+L++++Nd IgD+G++ L+
  EFC35649.1 183 QLTSLEIACNDsIGDAGIIYLS 204
                 59***************99875 PP

  == domain 5  score: 6.8 bits;  conditional E-value: 0.0027
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 hLt Ld+s  +Ig  Ga+ +
  EFC35649.1 208 HLTNLDISRIKIGSGGAQYI 227
                 9************9999876 PP

  == domain 6  score: 4.3 bits;  conditional E-value: 0.016
       LRR_6   5 LteLdLsgNdIgDe 18 
                 Lt L+++ + I+De
  EFC35649.1 233 LTCLNINTCSIDDE 246
                 9************9 PP

  == domain 7  score: 7.4 bits;  conditional E-value: 0.0017
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L  L++s N+I+ eGa+ ++
  EFC35649.1 256 KLIVLHISENEISIEGAKYIS 276
                 6889*************9875 PP

  == domain 8  score: -1.7 bits;  conditional E-value: 1.4
       LRR_6   3 thLteLdLsgNd 14 
                 + Lt+L +s  +
  EFC35649.1 279 NQLTSLYISESG 290
                 569999998655 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1     0.015        44      19      40 ..     105     122 ..      58     128 .. 0.83
   2 !   10.4   0.0   0.00024      0.71       3      37 ..     111     146 ..     109     155 .. 0.69
   3 !   17.3   0.1   1.6e-06    0.0048       1      39 [.     133     173 ..     133     177 .. 0.87
   4 !   11.2   0.3   0.00013      0.39       2      35 ..     159     194 ..     158     202 .. 0.83
   5 !    9.2   0.1   0.00057       1.7       1      33 [.     182     217 ..     182     222 .. 0.83
   6 !    9.3   0.1   0.00052       1.5       2      40 ..     208     244 ..     207     252 .. 0.80
   7 !   14.2   0.0   1.5e-05     0.046       1      32 [.     255     288 ..     255     293 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.015
                 HHH-TT--EEE-.-S-----GG CS
       LRR_4  19 leklpnLkeLdLsgNnlitdld 40 
                 +++l++L++L + g+    d+d
  EFC35649.1 105 IGQLKQLTSLEIQGM----DID 122
                 4579******99998....876 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00024
                 --EEE--SS---E-S-HH...H-TT--EEE-.-S---- CS
       LRR_4   3 LevLdLsnNqltdiplle...klpnLkeLdLsgNnlit 37 
                 L++L +++  + d    e    l++L++L++sgN +i+
  EFC35649.1 111 LTSLEIQGMDIDDEHV-EsmaELKQLTSLYISGN-YIG 146
                 6666666645554222.13534***********9.875 PP

  == domain 3  score: 17.3 bits;  conditional E-value: 1.6e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitdl 39 
                 ++L++L++s+N + + +     e++ +L++L++s N +i+++
  EFC35649.1 133 KQLTSLYISGNYIGSEGVkiiSESFNKLTKLNISAN-YIDNV 173
                 58************9999985558*********998.99876 PP

  == domain 4  score: 11.2 bits;  conditional E-value: 0.00013
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 +L++L++s N +  ++   +++l++L++L +  N  
  EFC35649.1 159 KLTKLNISANYIDNVGAkyISQLKQLTSLEIACNDS 194
                 79******88****99987668********966644 PP

  == domain 5  score: 9.2 bits;  conditional E-value: 0.00057
                 SS--EEE--SS.---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnN.qltdipl..leklpnLkeLdLsgN 33 
                 ++L++L ++ N  + d +   l++l +L+ Ld+s+ 
  EFC35649.1 182 KQLTSLEIACNdSIGDAGIiyLSGLEHLTNLDISRI 217
                 5799999**9988***99977778*********775 PP

  == domain 6  score: 9.3 bits;  conditional E-value: 0.00052
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GG CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdld 40 
                 +L++Ld+s  ++ + +   ++k+ +L+ L+++ +    ++d
  EFC35649.1 208 HLTNLDISRIKIGSGGAqyIGKFEQLTCLNINTC----SID 244
                 79******98888755576668*********878....554 PP

  == domain 7  score: 14.2 bits;  conditional E-value: 1.5e-05
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsg 32 
                 ++L+vL++s N ++ i++   ++kl +L++L++s+
  EFC35649.1 255 KKLIVLHISENEIS-IEGakyISKLNQLTSLYISE 288
                 69************.778576668*********76 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   2.5e-07   0.00074       6      38 ..       8      42 ..       8      44 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.5e-07
  F-box-like  6 dEiLlqIFsyL.pps.dLlrlalVCrrWrrvaldt 38
                d+i+ +I s+  +++    ++alV+++W++v+l+t
  EFC35649.1  8 DDIIYEIVSFYgDFKfLVMNCALVSKQWYNVILST 42
                67888999977789955667************987 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0         6   1.8e+04       2       9 ..     111     118 ..     110     127 .. 0.71
   2 !    6.8   0.0    0.0043        13       1      20 [.     134     157 ..     134     160 .. 0.72
   3 ?    3.1   0.0     0.069   2.1e+02       1      20 [.     159     178 ..     159     181 .. 0.78
   4 ?    0.5   0.1      0.53   1.6e+03       2       2 ..     206     206 ..     183     230 .. 0.57
   5 ?    2.4   0.3      0.13   3.8e+02       2      21 ..     233     252 ..     232     254 .. 0.79
   6 ?    0.8   0.0       0.4   1.2e+03       1      18 [.     256     273 ..     256     279 .. 0.73
   7 ?   -1.7   0.0       2.8   8.2e+03       2       8 ..     281     287 ..     280     293 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 6
       LRR_1   2 LrhLdLsn 9  
                 L++L + +
  EFC35649.1 111 LTSLEIQG 118
                 78888755 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0043
       LRR_1   1 nLrhLdLsnnpl....lglppnsf 20 
                 +L++L++s+n +      ++++sf
  EFC35649.1 134 QLTSLYISGNYIgsegVKIISESF 157
                 599********9666655566666 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.069
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++s n +++ ++ ++
  EFC35649.1 159 KLTKLNISANYIDNVGAKYI 178
                 79******999977666655 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.53
       LRR_1   2 L 2  
                 L
  EFC35649.1 206 L 206
                 1 PP

  == domain 5  score: 2.4 bits;  conditional E-value: 0.13
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L+++ +++++   +s++
  EFC35649.1 233 LTCLNINTCSIDDEVLQSIS 252
                 899*******9887777766 PP

  == domain 6  score: 0.8 bits;  conditional E-value: 0.4
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L +L++s n ++  ++ 
  EFC35649.1 256 KLIVLHISENEISIEGAK 273
                 7999****9998555555 PP

  == domain 7  score: -1.7 bits;  conditional E-value: 2.8
       LRR_1   2 LrhLdLs 8  
                 L++L++s
  EFC35649.1 281 LTSLYIS 287
                 999**97 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00012      0.36      23      38 ..      25      40 ..       8      43 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00012
                HHHHCTT-HHHHHHHT CS
       F-box 23 llalrrVSkgwrilid 38
                + ++++VSk w+++i 
  EFC35649.1 25 VMNCALVSKQWYNVIL 40
                889**********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       694  (0.0387082); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1803.07
//
Query:       EFC35650.1  [L=119]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00021   21.1   0.1    0.00038   20.3   0.1    1.4  1  DUF501    Protein of unknown function (DUF501)


Domain annotation for each model (and alignments):
>> DUF501  Protein of unknown function (DUF501)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.1   2.1e-08   0.00038       2      44 ..      73     118 ..      72     119 .] 0.81

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 2.1e-08
      DUF501   2 aarcadgvPvvlltaplrkklsrgk...pfptlywLtcpelvkavs 44 
                  +rc++g+P+v      ++k++ ++   +  t +wLtcp+++  ++
  EFC35650.1  73 VKRCKWGYPQVTFAFTSKNKAETSEntyVPGTFLWLTCPRVNLIID 118
                 589**********999998887765665556888******987776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1115  (0.0621897); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.27s 00:00:00.71 Elapsed: 00:00:00.42
# Mc/sec: 848.48
//
Query:       EFC35651.1  [L=275]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.068   12.2   0.1      0.091   11.8   0.1    1.2  1  IIGP      Interferon-inducible GTPase (IIGP)


Domain annotation for each model (and alignments):
>> IIGP  Interferon-inducible GTPase (IIGP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   5.1e-06     0.091     196     239 ..      58     101 ..      15     130 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.1e-06
                 BBTTBTTSTTHHHHHHHHHHHS-GGGHHHHHHHS---SHHHHHH CS
        IIGP 196 vsnldvsayDFPkLretLlkdlpaikrhefleslsnvtdkviee 239
                 +s  +v ++ FP L++tL  +++ i+r+e l  l  ++ + i++
  EFC35651.1  58 LSLEQVFTFSFPLLKNTLVGEFFEIRRRENLMKLVVIMTSLISD 101
                 56778899**************************9999999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       652  (0.0363657); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1830.28
//
Query:       EFC35652.1  [L=629]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.4e-06   26.4   0.0    1.1e-05   25.1   0.0    1.7  1  Peptidase_S41    Peptidase family S41
  ------ inclusion threshold ------
       0.15   11.9   9.5      0.063   13.0   6.7    2.0  1  Ephrin_rec_like  Putative ephrin-receptor like
        9.2    6.3   7.2        7.3    6.6   0.4    2.7  2  cEGF             Complement Clr-like EGF-like


Domain annotation for each model (and alignments):
>> Peptidase_S41  Peptidase family S41
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.0   1.8e-09   1.1e-05       1     115 [.     191     383 ..     191     401 .. 0.71

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 1.8e-09
                    EEEEEEES-B..CC..THHHHHHHHHHHHHHTTSSEEEEE-TTB-EBEHHHHHHHHHCCSSSSEEEEEECTTSEEE.................... CS
  Peptidase_S41   1 kiGyiripsf..se..ktkeelakalkelkkknvkglilDlRnNgGGlldeavelaslflddglivstrgrdgkkk.................... 72 
                    k+G+i+++sf  +   + +++++ a+   k ++++ +i+D++nNgGG     ++l+++++ +     ++    +++                    
     EFC35652.1 191 KVGVITVESFvpKDevQFAKDFQTAMYLAKLNKIPRIIVDVTNNGGGEECLGYALIKYLHSNAFSSNFETLFARTDmiatelgrqlatagtklspd 286
                    79********5411574445554444433336***************************9998888888887777777888888888888888888 PP

                    .......................................................EEEHTCSS-S.......TT-BSSEEEEEE-TTBBTHHHHHH CS
  Peptidase_S41  73 .......................................................kksktekase.......evqykgplvvLvnegsaSaseifa 106
                                                                           +                 +      ++L n+++aS    f+
     EFC35652.1 287 adsiwnfatwktidgknfkdetwytnqksyirgtdgkpafyssilkenycqpsfdN--------YyftgedlLKYSPDDFILLSNGRCASTCALFT 374
                    88888888888888877777766666666666666665555555555555444432........03334443345667788888888888888888 PP

                    HHHHHTTSE CS
  Peptidase_S41 107 galkdngra 115
                      l++ + +
     EFC35652.1 375 RHLQESQKV 383
                    888887765 PP

>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   6.7   1.1e-05     0.063       5      33 ..     531     559 ..     527     574 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.1e-05
  Ephrin_rec_like   5 ntgletCipCprgtYqneegqlsClaCP..l 33 
                      +++ + CipC +g Y++  gqlsC+aC   +
       EFC35652.1 531 SAEKKNCIPCAIGEYNP--GQLSCTACTnkP 559
                      467789*********87..9*******8542 PP

>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.4    0.0012       7.3       5      20 ..     523     538 ..     518     539 .. 0.93
   2 ?    1.9   1.6     0.037   2.2e+02       5      20 ..     577     592 ..     574     592 .. 0.92

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0012
                 E-STTEEE.ETTTEEE CS
        cEGF   5 sCppGYkltpdGrsCt 20 
                 sC+pG+  ++  ++C+
  EFC35652.1 523 SCNPGFGFSAEKKNCI 538
                 7**************7 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.037
                 E-STTEEE.ETTTEEE CS
        cEGF   5 sCppGYkltpdGrsCt 20 
                 +C +GY  +++ ++C+
  EFC35652.1 577 ACDDGYDYNASKNTCV 592
                 5**************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (629 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       837  (0.0466841); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.36s 00:00:01.10 Elapsed: 00:00:00.54
# Mc/sec: 3531.14
//
Query:       EFC35653.1  [L=397]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.045   13.3   0.2        6.3    6.3   0.0    2.4  2  SGL       SMP-30/Gluconolactonase/LRE-like region


Domain annotation for each model (and alignments):
>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0    0.0011        20     122     151 ..      97     128 ..      78     152 .. 0.81
   2 ?    6.3   0.0   0.00035       6.3     114     153 ..     223     266 ..     210     310 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0011
         SGL 122 pd.gklervlddltipNGlawspdgktlYl.a 151
                 p+  k++ +  +++++N  +w+ d++t Y   
  EFC35653.1  97 PSpPKINYQCGRVMVSNNNMWNTDNDTTYClS 128
                 555678888899*****************743 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.00035
         SGL 114 v....galyrldpdgklervlddltipNGlawspdgktlYlaDs 153
                 +    +++y++d d+  + +++  ti+NG+a+  d   +++ + 
  EFC35653.1 223 GlkldTKVYVWDEDNMPNTTKSYYTISNGVAFLMDAVRVFVKEN 266
                 1334689*******999999999*********999988887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.27s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2409.80
//
Query:       EFC35654.1  [L=965]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.039   14.1   0.2       0.13   12.4   0.2    1.9  1  RINGv            RING-variant domain
       0.04   13.0   1.6      0.095   11.8   1.6    1.6  1  ABC2_membrane_3  ABC-2 family transporter protein
        1.7    8.7   9.6        3.6    7.6   9.6    1.5  1  FAD-SLDH         Membrane bound FAD containing D-sorbitol deh
        8.6    7.1  14.4         19    6.0  12.2    2.7  2  DUF2203          Uncharacterized conserved protein (DUF2203)


Domain annotation for each model (and alignments):
>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.2   2.8e-05      0.13      13      33 ..     249     268 ..     231     279 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.8e-05
                 --B-SS--STCCCSB-HHHHH CS
       RINGv  13 plispCkCrGslklvHesCle 33 
                 +l+s+C+CrG +kl H+sC +
  EFC35654.1 249 NLVSECECRG-VKLRHNSCKS 268
                 79********.********66 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.6   2.1e-05     0.095      94     151 ..      51     137 ..      10     155 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.1e-05
  ABC2_membrane_3  94 l.............................kgesatvtvlinssnlnsskailnalnsllqqlnasalv.........lqseatstsaninves 149
                      l                             k+  ++v+ +i+s+++  s+++l++l++llq++  ++l+         +         + ++e+
       EFC35654.1  51 LetselnrcknvcgsnyipediclkliltqKQFHDQVVKFIYSKQQDESDQLLSQLQQLLQEQQEQQLQqlqqqqeqqQ---------QQQLEE 135
                      15555555555555555555555555566645556778888999999***********777766666664644444331.........333333 PP

  ABC2_membrane_3 150 tq 151
                      t+
       EFC35654.1 136 TS 137
                      32 PP

>> FAD-SLDH  Membrane bound FAD containing D-sorbitol dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   9.6   0.00081       3.6      46     111 ..      77     140 ..      73     142 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00081
    FAD-SLDH  46 lLtgrkkLdpalgarlyaalvaedaefkaqlaaLaallekqkakdveallaaaaadaalkdlalkI 111
                 +Lt+++    ++ + +y++ ++e +++ +ql++L++  ++q++++ ++++++ +++++l+++  +I
  EFC35654.1  77 ILTQKQ-FHDQVVKFIYSKQQDESDQLLSQLQQLLQEQQEQQLQQLQQQQEQ-QQQQQLEETSNEI 140
                 456555.9999999*****999999999999999999999999999999999.9999999998887 PP

>> DUF2203  Uncharacterized conserved protein (DUF2203)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0  12.2    0.0043        19       6      86 ..      97     177 ..      95     186 .. 0.73
   2 ?   -1.2   0.0      0.71   3.2e+03      38      69 ..     204     235 ..     174     244 .. 0.61

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0043
     DUF2203   6 eeAnalLpllkelleelralrkeleeleeeleeakaeaekse......aaeleaeleeleaeieelveeieelGvevkdleaglvDF 86 
                 +e  +lL +l++ll+e ++++ +  + ++e +++++ +e  +      +++ ++++++ ++ ++ l ee+++  ve+ d     +DF
  EFC35654.1  97 DESDQLLSQLQQLLQEQQEQQLQQLQQQQEQQQQQQLEE--TsneitiRTQIQQQIKHHTELLKLLQEELQQCRVELEDD----CDF 177
                 68899**********999554433333333333333333..23479999999***********************99986....666 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.71
     DUF2203  38 eakaeaekseaaeleaeleeleaeieelveei 69 
                 e +++++ ++ ++ +++l+++e++++e +++ 
  EFC35654.1 204 EDRTTYTPKKPSKVNEKLDKIENQLDECIKKY 235
                 33333333336777788888888888777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (965 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4281  (0.238775); expected 358.6 (0.02)
Passed bias filter:                      786  (0.0438396); expected 358.6 (0.02)
Passed Vit filter:                       126  (0.00702772); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.26u 0.39s 00:00:01.65 Elapsed: 00:00:00.57
# Mc/sec: 5086.68
//
Query:       EFC35655.1  [L=302]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.024   14.8   0.0      0.044   13.9   0.0    1.4  1  CAMSAP_CKK  Microtubule-binding calmodulin-regulated spectrin


Domain annotation for each model (and alignments):
>> CAMSAP_CKK  Microtubule-binding calmodulin-regulated spectrin-associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   2.5e-06     0.044      35      78 ..     234     277 ..     209     293 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.5e-06
  CAMSAP_CKK  35 kkvleelekseskhfliLfrdsklqyralYslseeeeelvklaG 78 
                  ++l  l++s+ k+++i +rd+ ++yr l    + e++  kl+G
  EFC35655.1 234 ATILSRLDESNEKVLMIHYRDTAKKYRHLVRRISFEDNNGKLVG 277
                 5799************************9877666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       478  (0.0266607); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.57
# Mc/sec: 1597.25
//
Query:       EFC35656.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       592  (0.0330191); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1138.13
//
Query:       EFC35657.1  [L=474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.7e-07   29.6   0.0    8.1e-07   28.8   0.0    1.4  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0   4.5e-11   8.1e-07       2     155 ..      22     187 ..      21     237 .. 0.74

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 4.5e-11
                    EEEESTG.....CHHHHTHHHHHHHHHHHHHHCTTSEEEEEEEBSCTCHHHHHHHHH................TTCEEEEECCHECSSSTTSSEEE CS
                    xxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................xxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos   2 twNvngq.....aspalgssrrsdrladlltaydaDvlgLQEvdddelsriplllal................ggflgasstsptgggggggngga 76 
                    ++Nv ++      s+        + l + l++++ D+++L+Ev+ d++   pl  +                 ++          + g ++++   
     EFC35657.1  22 SFNVHHFstaygRSN-------LTELYKYLHKNNFDIVCLNEVYEDSEYSHPLRDLVyalnsslpeevevarpYQ---------YRSGPTNYESNI 101
                    899999843332222.......2225555555566************9999999977777777777775544322.........34668899999* PP

                    EEECSTE.....EEEEEEEEEETSSSSGCEEEEEEEEEEEEEEE.......CCCHHGHHHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-SS CS
                    xxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  77 vlsrfpl.....tslfrrtfiefndlvaalrreplaakleqlni.......ashrdhdlvrdlqllalllqvealnadrgapvivaGDfNa 155
                    +ls++p+     + + r  ++  +++ ++   +++  +              ++   + v   ++   ++++ + ++d+++ +i++GDfN+
     EFC35657.1 102 ILSKYPIlfqekKDVGRGERSVLGIKIDHPLVRNVFVT-----HldhvsenKRVLQLKRVLSFMKHFIDRKLVDYPNDENKNFILLGDFNS 187
                    *******7554444444444444444444444444444.....255555999999999999999999999999****************** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.24s 00:00:00.80 Elapsed: 00:00:00.43
# Mc/sec: 3336.39
//
Query:       EFC35658.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0067   15.2   0.0      0.009   14.8   0.0    1.2  1  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0     5e-07     0.009     370     407 ..      13      50 ..       3      51 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5e-07
  Pkinase_fungal 370 garertGTleFmaievlkgeeHsyrhDLESffyvllwi 407
                     ++++ tGT+ + +++  kg e s r+DLES+ yvll+ 
      EFC35658.1  13 KDKHLTGTARYASLNNHKGYEQSRRDDLESLGYVLLYF 50 
                     45899*******************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       508  (0.028334); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.46
# Mc/sec: 978.75
//
Query:       EFC35659.1  [L=239]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00074   19.4   0.1       0.12   12.5   0.0    2.9  3  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0      0.76   1.4e+04       5      15 ..      85      94 ..      83     101 .. 0.65
   2 !   12.5   0.0   6.6e-06      0.12      12      27 ..     177     192 ..     176     193 .. 0.92
   3 !    3.9   0.0    0.0035        62       9      28 .]     218     238 ..     215     238 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 0.76
                EEEEEETTTEE CS
         NHL  5 hGvavdsnGdi 15
                +G+ ++ ++++
  EFC35659.1 85 WGLDLM-GNQV 94
                777776.5555 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 6.6e-06
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 +G +y +D+en+r++v
  EFC35659.1 177 SGLVYLSDTENNRIFV 192
                 699***********98 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.0035
                 EE.TTTEEEEEECCCTEEEEE CS
         NHL   9 vd.snGdiyVaDsenhrvqvF 28 
                 vd  +G +yV ++++  + +F
  EFC35659.1 218 VDkRTGLLYVVNNKSKEISIF 238
                 77789*********9999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       534  (0.0297841); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1519.14
//
Query:       EFC35660.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1185  (0.066094); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 968.21
//
Query:       EFC35661.1  [L=209]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-07   31.0   0.0    4.8e-07   30.3   0.0    1.4  1  AAA       ATPase family associated with various cellular acti


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   0.0   2.7e-11   4.8e-07      27     129 ..      10     108 ..       2     111 .. 0.76

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 2.7e-11
                 EEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEESS.....GGGSTHHHH CS
         AAA  27 leisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkkeskvivigatnr.....pdkldpall 120
                  e+   +l+ +yvg+++ k++++++ea+      +lfiDE+++l + +  s+++++++ +++++tel   k+++   i++ a+++       +++p l 
  EFC35661.1  10 KEVGRXDLVGEYVGHTAPKTQKVIDEARG----GVLFIDEAYSLSRGK--SSNDFGKECIEVIMTELTSGKDDTP--IIVFAGYDqeianFIEINPGLK 100
                 567778999****************9963....7**********7777..99*******************9755..4444444434333334455555 PP

                 STTSSEEEE CS
         AAA 121 rgRfdrkie 129
                  +R+ ++i 
  EFC35661.1 101 -SRIRKHIT 108
                 .66666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       558  (0.0311228); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1321.48
//
Query:       EFC35662.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 774.32
//
Query:       EFC35663.1  [L=306]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.8e-15   55.1   9.7    8.2e-06   26.4   0.0    5.8  5  RCC1      Regulator of chromosome condensation (RCC1) repeat
    5.4e-11   42.0  20.4     0.0029   17.3   1.2    4.6  4  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.059   13.2   0.0       0.19   11.6   0.0    1.8  1  DUF2862   Protein of unknown function (DUF2862)


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.1   0.0    0.0059        35      28      48 ..      69      89 ..      42      91 .. 0.85
   2 !   11.7   0.2   5.3e-05      0.31       1      50 []      94     149 ..      94     149 .. 0.74
   3 !   26.4   0.0   1.4e-09   8.2e-06       1      50 []     152     203 ..     152     203 .. 0.91
   4 !   10.1   0.0   0.00017      0.99       3      45 ..     208     248 ..     206     253 .. 0.86
   5 ?    3.2   0.5     0.023   1.4e+02       2      13 ..     257     268 ..     256     269 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0059
                E-GGGTTS-EEEEEEETTEEE CS
        RCC1 28 kveglsgnrvvkvacGddhtv 48
                kv  l++ +vvkv +G +ht 
  EFC35663.1 69 KVVHLPNINVVKVISGRHHTH 89
                555666569**********96 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 5.3e-05
                 TTEEEEEE--GGGTTSSSS-.--E.EEE....EE-GGGTTS.-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt.esv.lvP....tkveglsgn.rvvkvacGddhtval 50 
                 +Gr++s+G n +G L +g +       P     + eg  ++ ++++ a G++h++++
  EFC35663.1  94 EGRILSFGTNAHGELCCGVSgA-LgGSPirglIRAEGVINEyKIIDGAGGGYHSIFI 149
                 7****************99853.3355844333334444449999999999999986 PP

  == domain 3  score: 26.4 bits;  conditional E-value: 1.4e-09
                 TTEEEEEE--GGGTTSSSS---EEEEEE-..GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkv..eglsgnrvvkvacGddhtval 50 
                 dG+V+  G+n+ +qLG+ +tes+ +P+k+    ++g+++ kv + + h+v++
  EFC35663.1 152 DGSVFVNGSNSANQLGISDTESQKKPVKLpsDYFDGQPICKVGANNTHSVFI 203
                 9****************************55556666************997 PP

  == domain 4  score: 10.1 bits;  conditional E-value: 0.00017
                 EEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETT CS
        RCC1   3 rVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGdd 45 
                 +Vy  G++++G++   ++ sv  P +++++ +   ++v+cG+d
  EFC35663.1 208 QVYVAGSDSNGCCAGIKSSSV--PLLLKFPIQFTPIDVSCGYD 248
                 689999999999977777777..********99********98 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.023
                 TEEEEEE--GGG CS
        RCC1   2 GrVysWGrndyG 13 
                 G V+++G++++G
  EFC35663.1 257 GVVLGCGCGSHG 268
                 99*********9 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.7   0.0   6.1e-05      0.36       2      29 ..      79     106 ..      78     107 .. 0.88
   2 !   15.9   0.8   1.4e-06    0.0081       3      30 .]     138     165 ..     136     165 .. 0.90
   3 !   17.3   1.2   4.9e-07    0.0029       2      30 .]     191     219 ..     190     219 .. 0.94
   4 !    8.6   2.4   0.00027       1.6       2      29 ..     241     268 ..     241     269 .. 0.94

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 6.1e-05
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 ++v +G+ H+  +t +G++l++G N +G
  EFC35663.1  79 VKVISGRHHTHLITFEGRILSFGTNAHG 106
                 56668999*****************999 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 1.4e-06
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 + + G+yHs++++ dG V+  GsNs  Q
  EFC35663.1 138 DGAGGGYHSIFISIDGSVFVNGSNSANQ 165
                 55789********************988 PP

  == domain 3  score: 17.3 bits;  conditional E-value: 4.9e-07
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                  +v a++ Hs+++t++  V+  Gs+s+G+
  EFC35663.1 191 CKVGANNTHSVFITRNSQVYVAGSDSNGC 219
                 6899************************8 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.00027
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 ++vs+G++ + +Lt+ G Vl++G+ s+G
  EFC35663.1 241 IDVSCGYDDTKFLTSQGVVLGCGCGSHG 268
                 68999999999***************99 PP

>> DUF2862  Protein of unknown function (DUF2862)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   3.2e-05      0.19      26      43 ..     127     144 ..     120     150 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 3.2e-05
                 .EEEEEEEEE-SSSSEEE CS
     DUF2862  26 pvgtikdfKmtDGsgiGv 43 
                 ++g+i+++K++DG g G+
  EFC35663.1 127 AEGVINEYKIIDGAGGGY 144
                 58************9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (306 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       418  (0.0233142); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.45
# Mc/sec: 2043.49
//
Query:       EFC35664.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.1e-30  103.1   0.2    0.00025   20.8   0.0    6.4  6  LRR_6        Leucine Rich repeat
    1.7e-16   59.7  15.5    2.3e-06   27.3   0.6    4.2  5  LRR_8        Leucine rich repeat
    7.6e-15   54.8   9.0    0.00026   21.3   0.5    4.7  6  LRR_4        Leucine Rich repeats (2 copies)
    1.7e-08   33.8   0.2         25    6.0   0.0    6.6  7  LRR_1        Leucine Rich Repeat
    0.00017   21.5   8.3        1.2    9.1   0.2    6.1  7  ApoB100_C    Apolipoprotein B100 C terminal
     0.0006   19.8   1.9         38    4.4   0.0    6.1  7  DUF5490      Family of unknown function (DUF5490)
  ------ inclusion threshold ------
      0.024   15.2   1.0         60    4.3   0.0    4.0  4  Apo-VLDL-II  Apovitellenin I (Apo-VLDL-II)
      0.077   12.8   9.9       0.74    9.6   0.4    3.0  3  UPF0193      Uncharacterised protein family (UPF0193)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   1.5e-07   0.00034       5      24 .]     135     154 ..     132     154 .. 0.92
   2 !   16.0   0.0   4.1e-06    0.0091       5      24 .]     159     178 ..     156     178 .. 0.92
   3 !   15.2   0.1   7.4e-06     0.016       8      24 .]     186     202 ..     182     202 .. 0.91
   4 !   20.8   0.0   1.1e-07   0.00025       5      23 ..     207     225 ..     204     226 .. 0.91
   5 !    8.6   0.0   0.00094       2.1       5      24 .]     231     250 ..     228     250 .. 0.92
   6 !   13.6   0.0   2.3e-05     0.052       8      24 .]     258     274 ..     254     274 .. 0.91

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.5e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s+N Ig eGa+ ++
  EFC35664.1 135 LTSLDISHNLIGYEGAKYIS 154
                 9***************9885 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 4.1e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N+I+D+Ga+ ++
  EFC35664.1 159 LTSLNIYYNQISDKGAKYIS 178
                 9***************9885 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 7.4e-06
       LRR_6   8 LdLsgNdIgDeGaeaLa 24 
                 L++ +N IgDeGa+ ++
  EFC35664.1 186 LNIGSNRIGDEGAKYIS 202
                 9************9885 PP

  == domain 4  score: 20.8 bits;  conditional E-value: 1.1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++s N+I DeGa+ +
  EFC35664.1 207 LTSLNVSNNEIRDEGAKFI 225
                 9***************987 PP

  == domain 5  score: 8.6 bits;  conditional E-value: 0.00094
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++  N I+ eGa+ ++
  EFC35664.1 231 LTSLNVYKNRISVEGAKYIS 250
                 9***************9885 PP

  == domain 6  score: 13.6 bits;  conditional E-value: 2.3e-05
       LRR_6   8 LdLsgNdIgDeGaeaLa 24 
                 L++ +N I+DeGa+ ++
  EFC35664.1 258 LNIGSNRISDEGAKYIS 274
                 9************9885 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.71   1.6e+03       8      21 ..      50      63 ..      49      67 .. 0.81
   2 !   18.2   0.2     7e-07    0.0016      21      61 .]     129     169 ..     125     169 .. 0.88
   3 !   27.3   0.6     1e-09   2.3e-06       2      61 .]     158     217 ..     157     217 .. 0.98
   4 !   23.1   0.9     2e-08   4.5e-05       5      61 .]     185     241 ..     181     241 .. 0.95
   5 !   20.7   0.1   1.1e-07   0.00025       2      55 ..     230     283 ..     229     285 .. 0.96

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.71
                -TTS--SEE-TTSS CS
       LRR_8  8 LsnNrltslddeaF 21
                +++  ++ +dd++F
  EFC35664.1 50 ICFEIISMIDDSWF 63
                6777899******9 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 7e-07
                 STT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  21 FkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  + +++L++Ld+s+Nl+    ++ +s +++L+sL++ +N++
  EFC35664.1 129 ISEMKQLTSLDISHNLIGYEGAKYISEMKQLTSLNIYYNQI 169
                 56699999999999999999999999999999999999987 PP

  == domain 3  score: 27.3 bits;  conditional E-value: 1e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  N++++ + +  + +++L  L++++N++    ++ +s +++L+sL++s+N +
  EFC35664.1 158 QLTSLNIYYNQISDKGAKYISEMKQLILLNIGSNRIGDEGAKYISEMKQLTSLNVSNNEI 217
                 7*********************************************************87 PP

  == domain 4  score: 23.1 bits;  conditional E-value: 2e-08
                 EEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   5 sLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  L++ +Nr+ + + +  + +++L++L+ snN+++   ++ +s +++L+sL++  Nr+
  EFC35664.1 185 LLNIGSNRIGDEGAKYISEMKQLTSLNVSNNEIRDEGAKFISEMKQLTSLNVYKNRI 241
                 69*************************************************999987 PP

  == domain 5  score: 20.7 bits;  conditional E-value: 1.1e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 +LtsL++ +Nr+++ + +  + +++L  L++++N+++   ++ +s +++L+sL+
  EFC35664.1 230 QLTSLNVYKNRISVEGAKYISEMKQLILLNIGSNRISDEGAKYISEMKQLTSLH 283
                 7*************************************************9996 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0   0.00067       1.5      17      36 ..     130     145 ..     125     149 .. 0.75
   2 !   20.2   0.1   2.6e-07   0.00058       1      38 [.     133     171 ..     133     174 .. 0.81
   3 !   13.9   0.3   2.6e-05     0.057       1      38 [.     157     195 ..     157     199 .. 0.83
   4 !   20.1   0.4   2.7e-07   0.00061       1      38 [.     181     219 ..     181     221 .. 0.83
   5 !   21.3   0.5   1.2e-07   0.00026       1      36 [.     205     241 ..     205     248 .. 0.85
   6 !   10.3   0.1   0.00035      0.78       1      29 [.     253     283 ..     253     286 .] 0.84

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00067
                 S-HHH-TT--EEE-.-S--- CS
       LRR_4  17 plleklpnLkeLdLsgNnli 36 
                 +    +++L++Ld+s+N li
  EFC35664.1 130 SE---MKQLTSLDISHN-LI 145
                 33...999999999998.65 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 2.6e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+s+N +   +   ++ +++L++L++  N +i+d
  EFC35664.1 133 KQLTSLDISHNLIGYEGAkyISEMKQLTSLNIYYN-QISD 171
                 58********9***555576445*********777.8865 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 2.6e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++  Nq++d +   ++ +++L  L++ g n+i+d
  EFC35664.1 157 KQLTSLNIYYNQISDKGAkyISEMKQLILLNI-GSNRIGD 195
                 58************977776445*********.6558876 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 2.7e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L+ L++++N++ d +   ++ +++L++L++s+N  i+d
  EFC35664.1 181 KQLILLNIGSNRIGDEGAkyISEMKQLTSLNVSNN-EIRD 219
                 57999**********99986445*********555.7765 PP

  == domain 5  score: 21.3 bits;  conditional E-value: 1.2e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L+ snN ++d +  + + +++L++L++  N +i
  EFC35664.1 205 KQLTSLNVSNNEIRDEGAkFISeMKQLTSLNVYKN-RI 241
                 58*************999*6655*********777.66 PP

  == domain 6  score: 10.3 bits;  conditional E-value: 0.00035
                 SS--EEE--SS---E-S-..HHH-TT--EEE CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLd 29 
                 ++L+ L++++N+++d +   ++ +++L++L+
  EFC35664.1 253 KQLILLNIGSNRISDEGAkyISEMKQLTSLH 283
                 57999**********9998644599999996 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1         8   1.8e+04       7      13 ..      65      71 ..      64      75 .. 0.64
   2 ?    5.3   0.0     0.018        40       1      12 [.     134     145 ..     134     155 .. 0.82
   3 ?    5.7   0.0     0.013        29       1      21 [.     158     178 ..     158     180 .. 0.86
   4 ?    3.2   0.0     0.091     2e+02       2      20 ..     183     201 ..     182     204 .. 0.80
   5 ?    6.0   0.0     0.011        25       1      17 [.     206     222 ..     206     228 .. 0.77
   6 ?    1.3   0.0      0.36   8.1e+02       1      18 [.     230     247 ..     230     252 .. 0.77
   7 ?    3.2   0.0     0.087     2e+02       2      20 ..     255     273 ..     254     276 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 8
       LRR_1  7 Lsnnpll 13
                L+n+ l+
  EFC35664.1 65 LNNCALI 71
                6777665 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.018
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+s+n +
  EFC35664.1 134 QLTSLDISHNLI 145
                 599*******87 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++ +n+++++++ +++
  EFC35664.1 158 QLTSLNIYYNQISDKGAKYIS 178
                 599*********999888775 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.091
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L  L++++n++++ ++ ++
  EFC35664.1 183 LILLNIGSNRIGDEGAKYI 201
                 788*******988877766 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++snn + + ++
  EFC35664.1 206 QLTSLNVSNNEIRDEGA 222
                 599*******9966555 PP

  == domain 6  score: 1.3 bits;  conditional E-value: 0.36
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L++  n+++  ++ 
  EFC35664.1 230 QLTSLNVYKNRISVEGAK 247
                 599*******99766665 PP

  == domain 7  score: 3.2 bits;  conditional E-value: 0.087
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L  L++++n++++ ++ ++
  EFC35664.1 255 LILLNIGSNRISDEGAKYI 273
                 788*******998887766 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.3   0.0    0.0086        19       8      33 ..     114     141 ..     105     156 .. 0.86
   2 ?    0.6   0.1      0.25   5.6e+02       8      32 ..     139     164 ..     138     166 .. 0.77
   3 !    9.1   0.2   0.00055       1.2       9      32 ..     165     188 ..     158     193 .. 0.89
   4 ?    0.5   0.0      0.26   5.8e+02      11      34 ..     191     214 ..     187     218 .. 0.81
   5 ?    2.8   0.0      0.05   1.1e+02      13      32 ..     217     236 ..     208     252 .. 0.81
   6 ?    1.8   0.1       0.1   2.3e+02      18      32 ..     246     260 ..     237     265 .. 0.80
   7 ?    1.6   0.1      0.12   2.7e+02      10      30 ..     262     282 ..     254     286 .] 0.86

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0086
   ApoB100_C   8 efsdqlsdyyE..kliaeskrLiDLsIe 33 
                 efs+ l+ + E  k+i+e k+L  L I 
  EFC35664.1 114 EFSGYLLGSRErvKFISEMKQLTSLDIS 141
                 789999999996679*******999885 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.25
   ApoB100_C   8 efsdqlsdyy.EkliaeskrLiDLsI 32 
                 ++s  l+ y   k i+e k+L  L I
  EFC35664.1 139 DISHNLIGYEgAKYISEMKQLTSLNI 164
                 66777777652499******998877 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00055
   ApoB100_C   9 fsdqlsdyyEkliaeskrLiDLsI 32 
                  ++q+sd   k i+e k+Li L I
  EFC35664.1 165 YYNQISDKGAKYISEMKQLILLNI 188
                 69******************9988 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.26
   ApoB100_C  11 dqlsdyyEkliaeskrLiDLsIek 34 
                 +++ d   k i+e k+L  L + +
  EFC35664.1 191 NRIGDEGAKYISEMKQLTSLNVSN 214
                 5666677799******99998865 PP

  == domain 5  score: 2.8 bits;  conditional E-value: 0.05
   ApoB100_C  13 lsdyyEkliaeskrLiDLsI 32 
                 + d   k+i+e k+L  L +
  EFC35664.1 217 IRDEGAKFISEMKQLTSLNV 236
                 566667*********98877 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.1
   ApoB100_C  18 EkliaeskrLiDLsI 32 
                  k i+e k+Li L I
  EFC35664.1 246 AKYISEMKQLILLNI 260
                 599********9988 PP

  == domain 7  score: 1.6 bits;  conditional E-value: 0.12
   ApoB100_C  10 sdqlsdyyEkliaeskrLiDL 30 
                 s+++sd   k i+e k+L  L
  EFC35664.1 262 SNRISDEGAKYISEMKQLTSL 282
                 789999999*******99766 PP

>> DUF5490  Family of unknown function (DUF5490)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.29   6.6e+02      13      24 ..     123     134 ..     121     153 .. 0.88
   2 ?   -1.5   0.0       1.2   2.7e+03      11      24 ..     145     158 ..     139     177 .. 0.77
   3 ?   -1.7   0.0       1.3     3e+03      10      23 ..     168     181 ..     159     183 .. 0.82
   4 ?    3.8   0.0     0.025        57       8      24 ..     190     206 ..     187     211 .. 0.92
   5 ?    1.5   0.0      0.14   3.1e+02      10      24 ..     216     230 ..     209     235 .. 0.86
   6 ?    1.2   0.0      0.17   3.8e+02       9      24 ..     239     254 ..     234     256 .. 0.89
   7 ?    4.4   0.0     0.017        38       8      24 ..     262     278 ..     259     280 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.29
     DUF5490  13 eerakffqnmkh 24 
                  er kf  +mk 
  EFC35664.1 123 RERVKFISEMKQ 134
                 699******996 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.2
     DUF5490  11 iaeerakffqnmkh 24 
                 i  e ak+  +mk 
  EFC35664.1 145 IGYEGAKYISEMKQ 158
                 55677888888875 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.3
     DUF5490  10 riaeerakffqnmk 23 
                 +i+++ ak+  +mk
  EFC35664.1 168 QISDKGAKYISEMK 181
                 68888899999998 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.025
     DUF5490   8 sqriaeerakffqnmkh 24 
                 s+ri +e ak+  +mk 
  EFC35664.1 190 SNRIGDEGAKYISEMKQ 206
                 89*************95 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.14
     DUF5490  10 riaeerakffqnmkh 24 
                  i +e akf  +mk 
  EFC35664.1 216 EIRDEGAKFISEMKQ 230
                 68899********95 PP

  == domain 6  score: 1.2 bits;  conditional E-value: 0.17
     DUF5490   9 qriaeerakffqnmkh 24 
                 +ri+ e ak+  +mk 
  EFC35664.1 239 NRISVEGAKYISEMKQ 254
                 79************95 PP

  == domain 7  score: 4.4 bits;  conditional E-value: 0.017
     DUF5490   8 sqriaeerakffqnmkh 24 
                 s+ri++e ak+  +mk 
  EFC35664.1 262 SNRISDEGAKYISEMKQ 278
                 89*************95 PP

>> Apo-VLDL-II  Apovitellenin I (Apo-VLDL-II)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.1     0.058   1.3e+02      46      70 ..      71      95 ..      63     104 .. 0.74
   2 ?    4.3   0.0     0.027        60      26      66 ..     166     206 ..     160     214 .. 0.86
   3 ?    2.1   0.0      0.13     3e+02      27      68 ..     215     256 ..     210     260 .. 0.83
   4 ?    2.0   0.0      0.14   3.1e+02      27      65 ..     239     277 ..     233     283 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.058
  Apo-VLDL-II 46 vletrniliketakvsilfeqlvek 70
                 +++    +ike +k+ i+f +   k
   EFC35664.1 71 ISKQFFNVIKERSKLVIQFKNKFTK 95
                 55555569***********876544 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.027
  Apo-VLDL-II  26 vnkvsPkvaqflvdivqipvvletrniliketakvsilfeq 66 
                  +n++s k a+++ ++ q  ++    n++  e ak    + q
   EFC35664.1 166 YNQISDKGAKYISEMKQLILLNIGSNRIGDEGAKYISEMKQ 206
                  699*****************999999999999986555555 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.13
  Apo-VLDL-II  27 nkvsPkvaqflvdivqipvvletrniliketakvsilfeqlv 68 
                  n +    a+f+ ++ q + +   +n++  e ak    + ql+
   EFC35664.1 215 NEIRDEGAKFISEMKQLTSLNVYKNRISVEGAKYISEMKQLI 256
                  66777789999999****999999999999999777777765 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.14
  Apo-VLDL-II  27 nkvsPkvaqflvdivqipvvletrniliketakvsilfe 65 
                  n++s   a+++ ++ q  ++    n++  e ak    + 
   EFC35664.1 239 NRISVEGAKYISEMKQLILLNIGSNRISDEGAKYISEMK 277
                  889999999999999999999999999999888655555 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         3   6.8e+03     125     125 ..      35      35 ..      11      60 .. 0.55
   2 ?    8.5   0.4   0.00071       1.6     165     207 ..     119     161 ..      73     164 .. 0.77
   3 ?    9.6   0.4   0.00033      0.74     166     205 ..     215     255 ..     202     259 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3
     UPF0193 125 r 125
                 +
  EFC35664.1  35 K 35 
                 1 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00071
     UPF0193 165 vkeIeeRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 +   +eR++F++eM++L   +  ++ I  e ++ + e+++l +
  EFC35664.1 119 LLGSRERVKFISEMKQLTSLDISHNLIGYEGAKYISEMKQLTS 161
                 44559**********************************9975 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00033
     UPF0193 166 keIe.eRkeFLeeMeaLGqgkkYraiIeteIsqklreleal 205
                 +eI+ e ++F++eM++L   + Y++ I  e ++ + e+++l
  EFC35664.1 215 NEIRdEGAKFISEMKQLTSLNVYKNRISVEGAKYISEMKQL 255
                 577624689*****************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       922  (0.0514251); expected 358.6 (0.02)
Passed bias filter:                      251  (0.0139997); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 1672.52
//
Query:       EFC35665.1  [L=302]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0026   18.6   0.0     0.0046   17.8   0.0    1.4  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
      0.018   14.2   0.8      0.027   13.6   0.0    1.6  2  DRAT            Dinitrogenase reductase ADP-ribosyltransferas


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   5.1e-07    0.0046      10      94 ..     159     233 ..     150     235 .. 0.78

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 5.1e-07
                     -EEEEE-SS----TT.-.EEEEEEEEE....E.T-B--EEE..........---TT-EEEEE-..B-TEEE--B.-SS-EEEEEEE CS
  2OG-FeII_Oxy_3  10 qeykpHvDnfekeegsgqrrltvllyLnekes.eeGGelelyekdkeavkikpkkgrlvlFesdellpHevlpvtkggeRlsltgw 94 
                     + y++H+D        ++  l vl y+   ++  eGG+l ++ ++ +  +++ ++ +lv+ +s+ +  H+v++vt+g  R+ l+++
      EFC35665.1 159 KPYRKHTDG-------NDIGLGVLTYFG--SEiIEGGNLIIHIENLKVFNFPIQRRDLVFLNSK-FYAHQVTKVTSG-IRFGLVYF 233
                     459999995.......347799999996..3468*******77766999998899999999996.557******886.89887765 PP

>> DRAT  Dinitrogenase reductase ADP-ribosyltransferase (DRAT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   3.1e-06     0.027      13      73 ..      99     159 ..      90     168 .. 0.84
   2 ?   -3.0   0.1      0.38   3.4e+03      65      88 ..     258     282 ..     250     291 .. 0.53

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3.1e-06
        DRAT  13 slefneepvpleiagvrelhaelfekldeaedaeeaaevFqdymsvlFkleeaeeaeeaeg 73 
                  +e n++  p  ++ ++++++++f+kld++++  +  ++F +y + + +++++e+ + +++
  EFC35665.1  99 LHELNDKCGPFVLDKLKHINKNMFNKLDNINEDIKNYKIFAKYPTLALNVSHNENYNISKK 159
                 567899999999************************************9988887665554 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.38
        DRAT  65 aeeaeeaegekrrlkasYl.rllrg 88 
                 +e +ee++++ r+  ++Y  r+l+ 
  EFC35665.1 258 KELREERSKKGRKSMNEYKkRFLKK 282
                 4444444444455666664245554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1220  (0.0680462); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1789.45
//
Query:       EFC35666.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.5e-22   77.0   0.0    8.4e-05   22.3   0.0    5.3  5  LRR_6            Leucine Rich repeat
    3.2e-18   65.2   6.1      1e-06   28.4   0.1    2.5  3  LRR_8            Leucine rich repeat
    3.5e-15   55.9  13.2    0.00047   20.5   0.7    3.6  5  LRR_4            Leucine Rich repeats (2 copies)
    6.1e-09   35.2   0.0        9.7    7.2   0.0    5.1  5  LRR_1            Leucine Rich Repeat
      7e-05   22.4   1.3     0.0093   15.5   0.1    2.0  2  LRR_9            Leucine-rich repeat
    0.00065   20.2   0.1         12    6.5   0.0    3.1  3  Apo-VLDL-II      Apovitellenin I (Apo-VLDL-II)
     0.0018   18.2   1.1     0.0029   17.5   1.1    1.3  1  Beta_helix       Right handed beta helix region
     0.0031   18.0   0.0        8.2    7.0   0.0    3.0  3  Glyco_tranf_2_4  Glycosyl transferase family 2
  ------ inclusion threshold ------
      0.019   14.7   0.7        0.3   10.7   0.7    2.2  1  CAP59_mtransfer  Cryptococcal mannosyltransferase 1
      0.054   13.6   0.2         13    5.9   0.0    2.5  3  Arteri_GP4       Arterivirus glycoprotein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.0   0.00085       1.5       5      24 .]       4      23 ..       2      23 .. 0.80
   2 !   15.0   0.0   1.1e-05     0.019       5      24 .]      28      47 ..      25      47 .. 0.93
   3 !   15.5   0.0   7.2e-06     0.013       5      24 .]      52      71 ..      49      71 .. 0.91
   4 !   22.3   0.0   4.7e-08   8.4e-05       5      24 .]      76      95 ..      73      95 .. 0.92
   5 !    8.5   0.0    0.0013       2.3      11      24 .]     106     119 ..      98     119 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00085
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L +  N+I+D+Ga+ L+
  EFC35666.1  4 LTSLCIYNNEISDKGAKYLS 23
                6666666799******9886 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.1e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++s N+ +DeGa+ ++
  EFC35666.1 28 LTSLNVSNNETSDEGAKHIS 47
                9****************986 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 7.2e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L + +N+IgD+Ga+ ++
  EFC35666.1 52 LTSLYIYDNQIGDKGAKYIS 71
                9***************9885 PP

  == domain 4  score: 22.3 bits;  conditional E-value: 4.7e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++ +N+I+DeGa+ ++
  EFC35666.1 76 LTSLNIGYNEISDEGAKYIS 95
                9***************9885 PP

  == domain 5  score: 8.5 bits;  conditional E-value: 0.0013
       LRR_6  11 sgNdIgDeGaeaLa 24 
                   N+I+D+Ga+ L+
  EFC35666.1 106 YNNEISDKGAKYLS 119
                 5688******9886 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   0.3   2.9e-09   5.3e-06       2      61 .]       3      62 ..       2      62 .. 0.97
   2 !   28.4   0.1   5.8e-10     1e-06       2      61 .]      51     110 ..      50     110 .. 0.97
   3 !   24.8   0.1   7.6e-09   1.4e-05       2      54 ..      75     127 ..      74     128 .. 0.97

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 2.9e-09
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsL + nN +++ + +  + +++L++L+ snN+ +   ++ +s +++L+sL++ +N++
  EFC35666.1  3 QLTSLCIYNNEISDKGAKYLSEMKQLTSLNVSNNETSDEGAKHISEMKQLTSLYIYDNQI 62
                79********************************************************97 PP

  == domain 2  score: 28.4 bits;  conditional E-value: 5.8e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++ +N++ + + +  + +++L++L++++N+++   ++ +s +++L+ L++ +N +
  EFC35666.1  51 QLTSLYIYDNQIGDKGAKYISEMKQLTSLNIGYNEISDEGAKYISEMKQLTLLYIYNNEI 110
                 7*******************************************************9986 PP

  == domain 3  score: 24.8 bits;  conditional E-value: 7.6e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsL 54 
                 +LtsL++  N +++ + +  + +++L+ L++ nN+++   ++ +s +++L+sL
  EFC35666.1  75 QLTSLNIGYNEISDEGAKYISEMKQLTLLYIYNNEISDKGAKYLSEMKQLTSL 127
                 7**************************************************99 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.7   2.6e-07   0.00047       1      33 [.       2      36 ..       2      43 .. 0.86
   2 !   19.7   0.3   4.7e-07   0.00084       1      38 [.      26      64 ..      26      67 .. 0.87
   3 !   20.1   0.0   3.5e-07   0.00062       1      37 [.      50      87 ..      50      91 .. 0.82
   4 !   20.1   0.2   3.5e-07   0.00062       1      38 [.      74     112 ..      74     120 .. 0.87
   5 !    9.8   0.2    0.0006       1.1       1      28 [.      98     127 ..      98     128 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 2.6e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33
                ++L++L++ nN ++d +   l+ +++L++L++s+N
  EFC35666.1  2 KQLTSLCIYNNEISDKGAkyLSEMKQLTSLNVSNN 36
                58************977788777*********777 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 4.7e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38
                ++L++L+ snN  +d +   ++ +++L++L++ +N +i+d
  EFC35666.1 26 KQLTSLNVSNNETSDEGAkhISEMKQLTSLYIYDN-QIGD 64
                58*************99987555*********666.9976 PP

  == domain 3  score: 20.1 bits;  conditional E-value: 3.5e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37
                ++L++L++ +Nq+ d +   ++ +++L++L++  N  i+
  EFC35666.1 50 KQLTSLYIYDNQIGDKGAkyISEMKQLTSLNIGYN-EIS 87
                58************977776445*********556.665 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 3.5e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L+++ N ++d +   ++ +++L+ L++  Nn i+d
  EFC35666.1  74 KQLTSLNIGYNEISDEGAkyISEMKQLTLLYI-YNNEISD 112
                 58*************99986445*********.7778865 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.0006
                 SS--EEE--SS---E-S-..HHH-TT--EE CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeL 28 
                 ++L+ L++ nN ++d +   l+ +++L++L
  EFC35666.1  98 KQLTLLYIYNNEISDKGAkyLSEMKQLTSL 127
                 579***********9777876679999988 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0      0.03        54       1      21 [.       3      23 ..       3      25 .. 0.86
   2 ?    6.0   0.0     0.013        24       1      20 [.      27      46 ..      27      49 .. 0.75
   3 ?    6.0   0.0     0.014        25       1      21 [.      51      71 ..      51      73 .. 0.85
   4 !    7.2   0.0    0.0054       9.7       1      21 [.      75      95 ..      75      97 .. 0.83
   5 ?    5.1   0.0     0.027        49       2      21 ..     100     119 ..      99     121 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.03
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++L + nn ++++++ +++
  EFC35666.1  3 QLTSLCIYNNEISDKGAKYLS 23
                599*********999988776 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.013
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++L++snn  ++ ++ ++
  EFC35666.1 27 QLTSLNVSNNETSDEGAKHI 46
                599*******8666666555 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.014
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++L++ +n+++++++ +++
  EFC35666.1 51 QLTSLYIYDNQIGDKGAKYIS 71
                599*********999888775 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0054
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++L++++n +++ ++ +++
  EFC35666.1 75 QLTSLNIGYNEISDEGAKYIS 95
                599********9988877665 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.027
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L++ nn ++++++ +++
  EFC35666.1 100 LTLLYIYNNEISDKGAKYLS 119
                 899********999988776 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.1   5.2e-05     0.093      63     129 ..       1      66 [.       1      80 [. 0.85
   2 !   15.5   0.1   5.2e-06    0.0093      42     130 ..      26     115 ..      23     128 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.2e-05
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                 +k+l +l + nn i   + +    + +l++l ++nne  + +  + + ++k+l++l + +n + +k 
  EFC35666.1   1 MKQLTSLCIYNNEISDKGAKYLSEMKQLTSLNVSNNETSDEGA-KHISEMKQLTSLYIYDNQIGDKG 66 
                 688999********999999999999**********9999887.899************99998774 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 5.2e-06
       LRR_9  42 dqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkke 130
                  q+ ++++s+n+  +     +  +k+l +l++ +n+i   + +    + +l++l +  ne+ + +  + + ++k+l+ll + +n +++k  
  EFC35666.1  26 KQLTSLNVSNNETSDegAKHISEMKQLTSLYIYDNQIGDKGAKYISEMKQLTSLNIGYNEISDEGA-KYISEMKQLTLLYIYNNEISDKGA 115
                 5777888888888652245677899999*********9999999999999***********99988.999**************9998854 PP

>> Apo-VLDL-II  Apovitellenin I (Apo-VLDL-II)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0    0.0068        12      27      60 ..      12      45 ..       6      54 .. 0.83
   2 ?    5.7   0.0     0.012        22      20      63 ..      55      96 ..      49     102 .. 0.84
   3 ?    5.1   0.0     0.018        33      21      45 ..     104     126 ..      99     129 .] 0.84

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0068
  Apo-VLDL-II 27 nkvsPkvaqflvdivqipvvletrniliketakv 60
                 n +s k a++l ++ q + +  + n    e ak 
   EFC35666.1 12 NEISDKGAKYLSEMKQLTSLNVSNNETSDEGAKH 45
                 89****************9999999888887774 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.012
  Apo-VLDL-II 20 ayvyeavnkvsPkvaqflvdivqipvvletrniliketakvsil 63
                  y+y+  n++  k a+++ ++ q + +    n +  e ak    
   EFC35666.1 55 LYIYD--NQIGDKGAKYISEMKQLTSLNIGYNEISDEGAKYISE 96
                 68887..99*****************999999999999986544 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.018
  Apo-VLDL-II  21 yvyeavnkvsPkvaqflvdivqipv 45 
                  y+y+  n +s k a++l ++ q + 
   EFC35666.1 104 YIYN--NEISDKGAKYLSEMKQLTS 126
                  6665..9*************99875 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   1.1   1.6e-06    0.0029      35     136 ..       8     112 ..       2     122 .. 0.68

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.6e-06
                 EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---SEEE-TT.--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT---EEE CS
  Beta_helix  35 vienneiannsgsGiyilgs.snntisnntisdnngggialf.gasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdsssnvtvt 130
                 +i nnei++ +   ++  ++ +  ++snn+ sd ++ +i  + +     i++n i d g   i+ + + +++ i +N i++ ++  i+ + + + +++ 
  EFC35666.1   8 CIYNNEISDKGAKYLSEMKQlTSLNVSNNETSDEGAKHISEMkQLTSLYIYDNQIGDKGAKYISEMkQLTSLNIGYNEISDEGAKYISEMKQLTLLYIY 106
                 677777777555555555556777788888887777777666567777778888888777666444357777788888887777777777777777777 PP

                 S-EEES CS
  Beta_helix 131 nNtitn 136
                 nN i++
  EFC35666.1 107 NNEISD 112
                 777776 PP

>> Glyco_tranf_2_4  Glycosyl transferase family 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0    0.0045       8.2      20      51 ..       5      36 ..       2      53 .. 0.69
   2 ?    3.9   0.0     0.044        79      19      44 ..      52      77 ..      42      99 .. 0.79
   3 ?    4.6   0.0     0.026        47      20      44 ..     101     125 ..      91     129 .] 0.83

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0045
  Glyco_tranf_2_4 20 drilvydndstDgtrailkelpevkllhvdks 51
                     + +++y+n+ +D+ +++l+e+++++ l+v ++
       EFC35666.1  5 TSLCIYNNEISDKGAKYLSEMKQLTSLNVSNN 36
                     679****************9988774444432 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.044
  Glyco_tranf_2_4 19 fdrilvydndstDgtrailkelpevk 44
                      + +++ydn+  D+ +++++e+++++
       EFC35666.1 52 LTSLYIYDNQIGDKGAKYISEMKQLT 77
                     5789***********99999988765 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.026
  Glyco_tranf_2_4  20 drilvydndstDgtrailkelpevk 44 
                      + +++y+n+ +D+ +++l+e+++++
       EFC35666.1 101 TLLYIYNNEISDKGAKYLSEMKQLT 125
                      669***************9998765 PP

>> CAP59_mtransfer  Cryptococcal mannosyltransferase 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.7   0.00017       0.3      35      88 ..       6      68 ..       2     129 .] 0.78

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00017
  CAP59_mtransfer 35 fvSiyesgskdgtkeaLraleaelealgversivlneeteleldeles...........gkkelk 88
                     ++ iy+++ +d+ ++ L+++ ++l++l+v+++ +++ e  ++ +e+++           g+k  k
       EFC35666.1  6 SLCIYNNEISDKGAKYLSEM-KQLTSLNVSNNETSD-EGAKHISEMKQltslyiydnqiGDKGAK 68
                     689*****************.999*****9999776.4456677777666777776665333333 PP

>> Arteri_GP4  Arterivirus glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.67   1.2e+03      99     116 ..       4      21 ..       2      37 .. 0.80
   2 ?    5.0   0.0     0.014        25      80     116 ..      32      69 ..      12      74 .. 0.81
   3 ?    5.9   0.0     0.007        13      81     115 ..      81     116 ..      72     121 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.67
  Arteri_GP4  99 lsacliyaselsekGfkv 116
                 l++  iy  e+s+kG k 
  EFC35666.1   4 LTSLCIYNNEISDKGAKY 21 
                 566778999999999774 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.014
  Arteri_GP4  80 titanvt.desylhsadllmlsacliyaselsekGfkv 116
                  ++ n t de+ +h +++  l++  iy  ++ +kG k 
  EFC35666.1  32 NVSNNETsDEGAKHISEMKQLTSLYIYDNQIGDKGAKY 69 
                 55555543899***********************9886 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.007
  Arteri_GP4  81 itan.vtdesylhsadllmlsacliyaselsekGfk 115
                 i +n ++de+ ++ +++  l+   iy  e+s+kG k
  EFC35666.1  81 IGYNeISDEGAKYISEMKQLTLLYIYNNEISDKGAK 116
                 44443789**************************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      304  (0.0169558); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 839.82
//
Query:       EFC35667.1  [L=955]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (955 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1994  (0.111216); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.23s 00:00:00.83 Elapsed: 00:00:00.41
# Mc/sec: 6918.75
//
Query:       EFC35668.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      258  (0.0143901); expected 358.6 (0.02)
Passed Vit filter:                         8  (0.000446204); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1330.20
//
Query:       EFC35669.1  [L=661]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-40  139.5   0.0    5.4e-40  137.9   0.0    1.7  1  S-methyl_trans  Homocysteine S-methyltransferase
  ------ inclusion threshold ------
      0.058   13.2   0.6       0.29   10.9   0.1    2.3  2  Exo84_C         Exocyst component 84 C-terminal
       0.11   11.7   1.2       0.26   10.5   0.9    1.8  1  DUF3834         Protein of unknown function (DUF3834)


Domain annotation for each model (and alignments):
>> S-methyl_trans  Homocysteine S-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.9   0.0     9e-44   5.4e-40       1     238 [.     334     635 ..     334     652 .. 0.82

  Alignments for each domain:
  == domain 1  score: 137.9 bits;  conditional E-value: 9e-44
                     EEB---SHHHHHHT.----STTHHCCHH.H-HHHHHHHHHHHHHHT.-SEEE-TTTT--......GG.T--HHHHH.H...HHHHHHHHHHHHHH CS
  S-methyl_trans   1 lilDGgmgteLerr.adlseelwsaell.trpelikeihrdyleaG.adiieTnTyqas......kikgleeeeevee...lnraavelareaad 83 
                     lilDGg++t + +   +l+ +lw a++l  +p++i ++h dy++ G +di ++ +yq+s      ++ +++eee++e    + r++v++ar++++
      EFC35669.1 334 LILDGGISTYMTELgLELNGSLWGANYLlENPKAIAKVHSDYVHEGlCDICTSSSYQISqeglaaDHVSMKEEERIELasrMFRDSVQIARKVVR 428
                     79*********8778899999**8888868**************9989***********6665542224555555432555************** PP

                     HH....HEEEEE--HHHHCTS.....................-.-..-................--HHHHHHHHHHHHHHHHHCT-SEEEEEEE- CS
  S-methyl_trans  84 eaaaplfvagsvGpygatlsd.....................g.y..d.............l..lsfeelveahreqiralleagvDlllietip 139
                     e  ++l va+sv+++ga +s+                     g y  +             +    ++ ++++h +++r l+ a++D++l+et+p
      EFC35669.1 429 EK-EKL-VAASVSCFGASISNllgeakeyfgdyldkdvdsnsGhYvhKfvkqlseklgetlEksGMEQVIYDFHYPRVRELILAEPDFILLETMP 521
                     97.455.*******************999977777777766644455144455566666542556667789********8999************ PP

                     -HHHHHHHHH.HHT.....T....--EEEEE-ECCT.TETTS-BHHH.HHHHHCT-......TEEEEEEES--GGGHHHHHHHHHTT--S-..EE CS
  S-methyl_trans 140 dlleakaave.llaa....e....lpvwisftikdestlrsGetleeavaalaaat......qplavgvNCakpeelepllkelksetalpa.vi 218
                      l+e++++++ ++ +    +    ++v+isf +kd+ ++ +Ge++e++v+ + + +      +++avg NC +p+ +  l+++++++ ++++ +i
      EFC35669.1 522 VLKEVEILCDrVIPDilkeLnkkgIKVMISFYCKDGLHTGHGESIEKCVEYVNQDRfnpslfEIFAVGANCISPSIVPILIENIHTHLRKDIsII 616
                     ********996333334332566788********9854669******999999988*9*998889*******************8888888899* PP

                     EE---.S-----------.. CS
  S-methyl_trans 219 vypnsagevydltpeewaes 238
                     +ypns ge yd  +++w+  
      EFC35669.1 617 LYPNS-GEIYDNLTKSWSIP 635
                     ****8.***********855 PP

>> Exo84_C  Exocyst component 84 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   4.9e-05      0.29      17      77 ..     227     287 ..     222     348 .. 0.83
   2 ?   -0.6   0.0      0.16   9.8e+02       8      36 ..     405     433 ..     389     492 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 4.9e-05
     Exo84_C  17 rkFeeAVdlleklesklkklskklkdeeavlqdlislkveqrreelasklsrellsknevk 77 
                 +++eeA++++++ ++  +++ +++  +e+ +  +i+lk +  ++ l s+l++ l +++++ 
  EFC35669.1 227 KEYEEAINKINESKTTSAEIIRNIYLSEEPVMGVIRLKSKDHADMLSSSLINYLKNRSKKV 287
                 78***********************99999*********************9997655433 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.16
     Exo84_C   8 deldieiarrkFeeAVdlleklesklkkl 36 
                 +e  ie+a r F ++V+  +k+  + +kl
  EFC35669.1 405 EEERIELASRMFRDSVQIARKVVREKEKL 433
                 66678888888888888777765444444 PP

>> DUF3834  Protein of unknown function (DUF3834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.9   4.4e-05      0.26     148     196 ..     217     262 ..     197     269 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 4.4e-05
     DUF3834 148 avkeneeefidaYeeGIelikedpeeaaeyiaskLpikidkefiknilk 196
                 ++ke ++ ++++Yee I++i+e  +++ae+i +   i++++e + ++++
  EFC35669.1 217 TMKEASNAVVKEYEEAINKINESKTTSAEIIRN---IYLSEEPVMGVIR 262
                 4688899**********************9965...4777777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (661 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1227  (0.0684366); expected 358.6 (0.02)
Passed bias filter:                      774  (0.0431703); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.81u 0.36s 00:00:01.17 Elapsed: 00:00:00.54
# Mc/sec: 3689.73
//
Query:       EFC35670.1  [L=218]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0053   17.3   0.1     0.0093   16.5   0.1    1.4  1  MCM_N     MCM N-terminal domain
  ------ inclusion threshold ------
      0.057   13.3   0.1        0.1   12.4   0.1    1.4  1  MCM_OB    MCM OB domain


Domain annotation for each model (and alignments):
>> MCM_N  MCM N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.1     1e-06    0.0093      36      82 ..     104     150 ..      97     183 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1e-06
       MCM_N  36 kttLevdlddLaafdeeLaeailenpkeylplleealkevvkkleps 82 
                 ++++ +d+++  + + e+   +l++p e +p++e+al +  +++ ++
  EFC35670.1 104 HYSVFIDVSHFMSANIEIGSILLSYPTELIPIFERALIKTQQRHIEK 150
                 57899********************************9999886663 PP

>> MCM_OB  MCM OB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   1.2e-05       0.1       2      37 ..     182     217 ..     181     218 .] 0.88

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.2e-05
                 XGG--GGGTTSEEEEEEEEEEE---EEEEEEEEEEE CS
      MCM_OB   2 lRdlrsehigklvkveGivtrasevkpklkkavfec 37 
                 +R++rs + ++l++v+G+v+++  +k    k  + c
  EFC35670.1 182 VRSVRSCDANRLISVSGTVIKTGPIKMLEYKKIYIC 217
                 8*********************99998777777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1311.12
//
Query:       EFC35671.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      2e-46  158.8   2.8    2.5e-46  158.5   2.8    1.1  1  G-alpha         G-protein alpha subunit
  ------ inclusion threshold ------
      0.011   15.5   0.8      0.043   13.5   0.2    2.1  2  DNA_pol_A_exo1  3'-5' exonuclease
        2.8    8.0   8.3         19    5.2   0.0    2.3  2  MACPF           MAC/Perforin domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.5   2.8   4.1e-50   2.5e-46      11     211 ..      46     241 ..      16     255 .. 0.86

  Alignments for each domain:
  == domain 1  score: 158.5 bits;  conditional E-value: 4.1e-50
                 XXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH CS
     G-alpha  11 lkaerkarkkkrevkllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasli 109
                 ++++ + ++ + +vkllllG++eSGKsT++kq++++ +  f e+e++  ++ +++n+v+s+  ++++l++l+ e+    +++el++ ++++++++++  
  EFC35671.1  46 MNENADPNSGNYDVKLLLLGSGESGKSTFFKQVRIISQRPFLENERRRVKNTVHFNVVSSMAVMCQKLKELNLEF----SSEELSKCAERVLQLSKNR- 139
                 3344444444789*********************************************************98888....6777777777777777764. PP

                 ............HHCCHHC-HCHHHHHHHHCCSHHHHHHHC.CGCCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEE CS
     G-alpha 110 aklssateee..qeiefnpraevgedikaLwndpgiqelye.rrnkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdsklefr 205
                 a+++s+t+ +  + ++ ++  e+++di +Lw+d +iq++++ +rn++++ d+aeyF+++l+ i ++dY+p+++D+l++r+kt+Gi e++f+ + +l+f 
  EFC35671.1 140 AFMTSTTSVKggDRNFYTD--EIANDIYQLWKDSTIQKVFQnNRNDVHVFDGAEYFFERLDIIRKNDYIPSEEDLLYCRQKTIGIVEVSFDHE-SLKFS 235
                 4556666666789999999..********************666************************************************9.***** PP

                 EEEE-S CS
     G-alpha 206 ivdvgG 211
                 ++dv +
  EFC35671.1 236 LFDVVS 241
                 ***965 PP

>> DNA_pol_A_exo1  3'-5' exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.12   7.4e+02     119     138 ..     104     124 ..      86     144 .. 0.71
   2 ?   13.5   0.2   7.2e-06     0.043      67      94 ..     162     189 ..     145     235 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.12
                     SSHHHHHHHHHS.B---GHCC CS
  DNA_pol_A_exo1 119 hsLdsLaekylg.dleldkee 138
                      s++++++k+ + +le++ ee
      EFC35671.1 104 SSMAVMCQKLKElNLEFSSEE 124
                     799999999999545544443 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 7.2e-06
                     HHHHHHHT-TTSEEEESSHHHHHHHHHH CS
  DNA_pol_A_exo1  67 ealkrlledenitkvghnakfDlevlar 94 
                     + + +l++d++i+kv++n ++D++v++ 
      EFC35671.1 162 NDIYQLWKDSTIQKVFQNNRNDVHVFDG 189
                     556689*******************986 PP

>> MACPF  MAC/Perforin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   5.2     0.011        66     124     166 ..      11      53 ..       3      58 .. 0.83
   2 ?    5.2   0.0    0.0032        19     139     175 ..     134     172 ..      86     176 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.011
                 HHHHHHHHHHHHTT-SS-HHHH---EEEEEESS-GGG----HH CS
       MACPF 124 vslkgkkknssetkekksssqesessktlviGGepeseddksk 166
                  ++++++++ss++  k++++q +++      GG+ ++e  +++
  EFC35671.1  11 SQSSSSNNQSSNQDGKNKNNQRINDNDPNNEGGDEMNENADPN 53 
                 5667888889999999999***************999886655 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0032
                 SS-HHHH---EEEEEESS-GGG--..--HHHHHHHHHHT CS
       MACPF 139 kksssqesessktlviGGepesed..dksktyseWaesv 175
                 + s++ + ++s+t+v+GG+  + +   +++ y+ W++s+
  EFC35671.1 134 QLSKNRAFMTSTTSVKGGDRNFYTdeIANDIYQLWKDST 172
                 456688999*********9976667767779999*9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       906  (0.0505327); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1924.24
//
Query:       EFC35672.1  [L=192]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      275  (0.0153383); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1243.10
//
Query:       EFC35673.1  [L=425]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.045   13.5   0.0       0.14   11.9   0.0    1.8  1  DUF956    Domain of unknown function (DUF956)


Domain annotation for each model (and alignments):
>> DUF956  Domain of unknown function (DUF956)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   7.5e-06      0.14      45     101 ..     278     333 ..     268     339 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 7.5e-06
      DUF956  45 yiqipWeevdsvvasvlfkgklirrfaivtkkngkfsFsskdskkvLkavrkyvgke 101
                 ++ i +  ++++vas +f+ +l++     +k+ +++ Fss  +kkvL +++++ g+ 
  EFC35673.1 278 HMEISYRTIRQLVASKTFNIRLGHGVGFLLKS-TNYAFSSELTKKVLNKMEEHAGNL 333
                 478999*****************999999988.99*****************98875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (425 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       836  (0.0466284); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2540.94
//
Query:       EFC35674.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       543  (0.0302861); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.35u 0.26s 00:00:00.61 Elapsed: 00:00:00.41
# Mc/sec: 929.89
//
Query:       EFC35675.1  [L=462]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.6e-05   22.1   1.1    0.00018   21.1   1.1    1.6  1  SWIM      SWIM zinc finger
  ------ inclusion threshold ------
      0.071   13.1   0.8       0.15   12.1   0.8    1.5  1  FlxA      FlxA-like protein


Domain annotation for each model (and alignments):
>> SWIM  SWIM zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   1.1     2e-08   0.00018      14      39 ..     249     275 ..     241     276 .. 0.83

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 2e-08
        SWIM  14 katCsCpefqk.ngipCkHalAvllal 39 
                   +CsC +f +  g pCkH++ v+l+l
  EFC35675.1 249 GFFCSCDDFLHtCGRPCKHIYRVILSL 275
                 558********************9986 PP

>> FlxA  FlxA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.8   1.7e-05      0.15       3      36 ..     145     178 ..     143     180 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.7e-05
        FlxA   3 sssasssssssgsasqiasLqkQiknlqkqLkel 36 
                 +ss s +++++  +s i+sLqkQik  +++ k+l
  EFC35675.1 145 TSSMSFMNTTNYVESAIKSLQKQIKGTTQKKKSL 178
                 577788999999****************998877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (462 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       921  (0.0513693); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2909.15
//
Query:       EFC35676.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.6e-18   66.3   3.9    3.5e-18   65.9   3.9    1.1  1  Pkinase      Protein kinase domain
    3.4e-10   39.7   0.3    4.5e-10   39.3   0.3    1.2  1  Pkinase_Tyr  Protein tyrosine kinase
    0.00052   19.4   0.1    0.00086   18.7   0.1    1.3  1  Kdo          Lipopolysaccharide kinase (Kdo/WaaP) family
    0.00063   19.2   0.0    0.00096   18.6   0.0    1.3  1  Kinase-like  Kinase-like
  ------ inclusion threshold ------
      0.022   14.4   0.2      0.036   13.6   0.2    1.5  1  RIO1         RIO1 family
      0.044   13.7   0.0      0.057   13.3   0.0    1.3  1  APH          Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.9   3.9   1.2e-21   3.5e-18      51     246 ..     119     314 ..      96     318 .. 0.77

  Alignments for each domain:
  == domain 1  score: 65.9 bits;  conditional E-value: 1.2e-21
                 HHHHHSCTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEE CS
     Pkinase  51 ilkklkhpnivrlyevfee..kdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlake 147
                 i +k+k  +i  + +++e   +++++++ e +e++ l+++le    ls e   +++ q +e +  lH+++i+H+DlKp+N+L+ ++g l++tDF  ++ 
  EFC35676.1 119 IYNKVKEAEISCVQHYYEYleHQYFVIISEKAECD-LKTYLE-TNELSLEVRINLCVQYAELVLKLHEQNIVHCDLKPSNVLVLKDGSLRLTDFEGSSY 215
                 56677766665555555544499999*******99.9***98.5779999999*****************************************99999 PP

                 SSSSCS.BCTTTSCGGGS-HHHHTTSCB..SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHH CS
     Pkinase 148 lesssk.ltsfvgtseYlAPEvlkeney..skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkk 243
                 l+ +++ ++s + +  Y   E ++ +++    + D+++lG+ ++e+++  +p ++ ++k+++ k   ++ k        ++++  +++ s+++kdl++k
  EFC35676.1 216 LKDNKSfFNSHCKSIGYFD-ETVSVEQFqdLLNRDLFALGISFIEIFMC-NPNNHITTKHEFIKRK-EFAKYPYSTIYXTVESFLKNDQSRSIKDLIHK 311
                 9988888**********95.66654444237899************655.5555455554333322.22222222225567777788889*******99 PP

                 HT- CS
     Pkinase 244 llk 246
                 l +
  EFC35676.1 312 LQE 314
                 865 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.3   0.3   1.5e-13   4.5e-10      67     215 ..     134     276 ..     105     312 .. 0.73

  Alignments for each domain:
  == domain 1  score: 39.3 bits;  conditional E-value: 1.5e-13
                  EEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTS CS
  Pkinase_Tyr  67 lgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkee 164
                  +  +++++  +i+ e  ++ dL+++L+++   +l+l+  +++++q A+ +  L+++++vH dl   NvL+ ++   +++Df  ++ +++ ++   +++
   EFC35676.1 134 YYEYLEHQYFVIISE-KAECDLKTYLETN---ELSLEVRINLCVQYAELVLKLHEQNIVHCDLKPSNVLVLKDGSLRLTDFEGSSYLKD-NKSFFNSH 226
                  333445555555555.5667*******99...9************************************************99999944.44444444 PP

                  STSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTS.HHHHHH CS
  Pkinase_Tyr 165 aklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypgl.kneevl 215
                  +k    +    s+++ +   + D ++ G+  +Eif    +p +++ +++e++
   EFC35676.1 227 CKSIGYFDETVSVEQFQDLLNRDLFALGISFIEIFM--CNPNNHItTKHEFI 276
                  4433333333333333344688*************9..34444442444444 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.1   2.9e-07   0.00086     103     168 ..     152     212 ..     129     222 .. 0.88

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 2.9e-07
         Kdo 103 qdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldk 168
                  dL+++l++ +el+ e++ +l  + + l+ klh+ ++ H dl + n+l+ +++     + l D++ 
  EFC35676.1 152 CDLKTYLET-NELSLEVRINLCVQYAELVLKLHEQNIVHCDLKPSNVLVLKDG----SLRLTDFEG 212
                 599****97.88*************************************9999....888888875 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.0   3.2e-07   0.00096     138     189 ..     160     211 ..     117     230 .. 0.88

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 3.2e-07
  Kinase-like 138 hkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggft 189
                   ++l    r  l +q   l+ +L+++ +vh ++++ n+l  ++g l l++f+
   EFC35676.1 160 TNELSLEVRINLCVQYAELVLKLHEQNIVHCDLKPSNVLVLKDGSLRLTDFE 211
                  556666779999***************************************8 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.2   1.2e-05     0.036     117     159 ..     177     220 ..     122     244 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.2e-05
                 HHHHHHHTSTEEESS-STTSEEEETT.EEEE--GTTEEETTSTT CS
        RIO1 117 emrklykeaglvHaDLSeyNvlvded.kvviIDvsQaveldhpn 159
                 e+   ++e+++vH+DL   Nvlv +d  + + D+  +  l++++
  EFC35676.1 177 ELVLKLHEQNIVHCDLKPSNVLVLKDgSLRLTDFEGSSYLKDNK 220
                 445567899**************999899999998777666554 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.9e-05     0.057     155     197 ..     174     214 ..      99     216 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.9e-05
                 HHHHH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 155 alaallpgelptvllHgDlhpgNllvdpddgrvtGviDfedag 197
                 + a+l+++  ++ ++H+Dl+p N+lv   dg +  + Dfe ++
  EFC35676.1 174 QYAELVLKLHEQNIVHCDLKPSNVLVL-KDGSL-RLTDFEGSS 214
                 5566777778999**************.44444.477777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1999.42
//
Query:       EFC35677.1  [L=210]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (210 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       977  (0.0544927); expected 358.6 (0.02)
Passed bias filter:                      545  (0.0303977); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1418.81
//
Query:       EFC35678.1  [L=246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1782  (0.099392); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1582.38
//
Query:       EFC35679.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.8e-18   66.6   0.0    2.4e-18   66.2   0.0    1.2  1  GST_N       Glutathione S-transferase, N-terminal domain
    5.2e-15   55.6   0.0    6.3e-15   55.4   0.0    1.1  1  GST_N_3     Glutathione S-transferase, N-terminal domain
    4.1e-14   52.6   0.0      5e-14   52.3   0.0    1.1  1  GST_N_2     Glutathione S-transferase, N-terminal domain
  ------ inclusion threshold ------
       0.11   13.0   0.0       0.16   12.4   0.0    1.3  1  PSII_Pbs31  Photosystem II Psb31 protein


Domain annotation for each model (and alignments):
>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.2   0.0   5.5e-22   2.4e-18       4      75 ..       3      75 ..       1      76 [. 0.96

  Alignments for each domain:
  == domain 1  score: 66.2 bits;  conditional E-value: 5.5e-22
                EEESSSTSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTTS-SSEEEET..TEEEESHHHHHHHHH CS
       GST_N  4 tlysirgsprahrirlllaakgveyevvpldfeageekspellklnplgkvPaLedn..gkkltESraIleYia 75
                 lys  + p+ h+i ++l++ g+ey+   +d  +ge+ spe+lk+ p+ k+Pa +d+  g+ l+ES+aIl+Y+a
  EFC35679.1  3 DLYSLAT-PNGHKIAIALEEMGLEYKAHTIDIRKGEQFSPEFLKISPNNKIPAIVDQenGLALFESGAILQYLA 75
                5888888.9****************************************************************8 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.4   0.0   1.4e-18   6.3e-15       2      72 ..       5      79 ..       4      87 .. 0.87

  Alignments for each domain:
  == domain 1  score: 55.4 bits;  conditional E-value: 1.4e-18
                ES-TTSHHHHHHHHHHHHHT--EEEE---..TTTT.HHHHHHH-TT--SSEEETT..S-EEESHHHHHHHHHHHH- CS
     GST_N_3  2 ygfpaSpyarrvrlaLnekglpvevvevt..pgeh.deellaknplgkvPvLedd..gealtdSlaIidyLeelyp 72
                y+  + p+  ++++aL+e gl+++ + ++  +ge  ++e+l+++p++k+P+++d+  g al++S aI++yL ++ +
  EFC35679.1  5 YSLAT-PNGHKIAIALEEMGLEYKAHTIDirKGEQfSPEFLKISPNNKIPAIVDQenGLALFESGAILQYLADKSG 79
                55544.9*****************887765588889****************8766699************99865 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.3   0.0   1.1e-17     5e-14       3      69 ..      10      76 ..       8      77 .. 0.93

  Alignments for each domain:
  == domain 1  score: 52.3 bits;  conditional E-value: 1.1e-17
                HHHHHHHHHHHHCT--EEEEEEH...-TTSHHHHHHHHCTTTSSSEEE-C.TTEEEESHHHHHHHHHH CS
     GST_N_2  3 PwahRvlialalkglediisvvvlepkgfekseefprlnprgtVPvLwdk.dgqvineSseIlrylet 69
                P  h++ ial+++gle++ + + + +kg++ s+ef++++p+ ++P+++d  +g  + eS +Il+yl++
  EFC35679.1 10 PNGHKIAIALEEMGLEYKAHTI-DIRKGEQFSPEFLKISPNNKIPAIVDQeNGLALFESGAILQYLAD 76
                889***************9999.669***********************86888************86 PP

>> PSII_Pbs31  Photosystem II Psb31 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.6e-05      0.16      28      56 ..      50      79 ..      43      93 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.6e-05
  PSII_Pbs31 28 GdfaavveeknaftLFnsGay.ksaadKak 56
                  + a+v+++n + LF sGa+ +  adK+ 
  EFC35679.1 50 NKIPAIVDQENGLALFESGAIlQYLADKSG 79
                56789***************9766777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       239  (0.0133304); expected 358.6 (0.02)
Passed bias filter:                      230  (0.0128284); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 709.39
//
Query:       EFC35680.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-09   36.4   0.1    1.1e-08   35.2   0.1    1.6  1  BTB_2     BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2   0.1   6.3e-13   1.1e-08       1      55 [.     218     270 ..     218     271 .] 0.94

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 6.3e-13
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHH CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFet 55 
                 v+lnVgG +f+t+++tL+   ++l++ + +++     +++++++f+DR+pk+F++
  EFC35680.1 218 VTLNVGGQIFQTTSKTLR-GCESLFSLVFSEK-DTVLRDDNGHVFIDRDPKYFRY 270
                 89***************9.999****999966.99999***************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1597  (0.0890736); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.43
# Mc/sec: 1878.73
//
Query:       EFC35681.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0047   17.4   2.3     0.0066   17.0   2.3    1.3  1  PIN_12    PIN domain


Domain annotation for each model (and alignments):
>> PIN_12  PIN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   2.3   3.7e-07    0.0066      12      98 ..       7      94 ..       3     122 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3.7e-07
      PIN_12 12 ffrlseeealkklleliesgkiklivpdivldEflknrekkieeskkle.kalkslsklksakkklnekkkllslkeikkkieekvee 98
                 + l++ + +k l + +  ++ +  v ++vl+E  k+++k+i+++++++ ++lk+++  +s+++kl  +  + +  +  +k+++ +++
  EFC35681.1  7 EYSLEYTKLMKVLINIVLVNREYCKVAKQVLNESTKKYKKDISSIESAIeSKLKEYESTQSNQDKLLMLRLSSYTIQSISKLDSDLDA 94
                566666667777777788888888899****************995555577777777777777777777777777777777776554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2076  (0.11579); expected 358.6 (0.02)
Passed bias filter:                      664  (0.037035); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1042.21
//
Query:       EFC35682.1  [L=143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      266  (0.0148363); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 894.35
//
Query:       EFC35683.1  [L=246]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1580.51
//
Query:       EFC35684.1  [L=311]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-08   33.7  10.1    6.1e-08   32.7  10.1    1.6  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7  10.1   3.4e-12   6.1e-08       2      39 ..      42      78 ..      41      80 .. 0.86

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 3.4e-12
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                aC++Crk + KCd+k   Cs+C  +++eC++++ ++ r
  EFC35684.1 42 ACIRCRKLHKKCDKKLSGCSKCLAVGSECVYNTPQK-R 78
                9*************8888************555544.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1209  (0.0674327); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1904.94
//
Query:       EFC35685.1  [L=297]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.5   7.9      0.039   14.1   3.4    2.0  2  EamA      EamA-like transporter family


Domain annotation for each model (and alignments):
>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   3.4   2.2e-06     0.039       4      63 ..     160     218 ..     157     227 .. 0.86
   2 ?    0.5   0.1     0.036   6.4e+02      76      93 ..     279     296 ..     252     297 .] 0.73

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.2e-06
        EamA   4 illallaalfwaiyfvlskillrkvspltltfvrfliagillliiallkegklaklslkd 63 
                  l++ +   +++   +ls ++l+ ++p+ ++f+r ++  i l++i+l+ ++k+ k++ + 
  EFC35685.1 160 HLMIWTNLTLFSGFLILSPYGLKIYNPIIFSFFRGVVLVISLFPIMLFVDRKF-KFKSET 218
                 567777788899999**************************************.777665 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.036
        EamA  76 vlafllffyalkktsasn 93 
                 v+ +llf+ +l+ ts+++
  EFC35685.1 279 VVNQLLFVAGLNLTSSTV 296
                 577899999999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.42
# Mc/sec: 2112.56
//
Query:       EFC35686.1  [L=275]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-35  122.5   1.3    2.6e-35  122.1   1.3    1.1  1  Pkinase         Protein kinase domain
    5.6e-20   71.7   0.4      7e-20   71.4   0.4    1.1  1  Pkinase_Tyr     Protein tyrosine kinase
    5.3e-07   28.8   0.3    3.9e-06   25.9   0.0    2.3  3  Pkinase_fungal  Fungal protein kinase
    0.00046   20.2   0.1     0.0016   18.4   0.2    1.7  2  APH             Phosphotransferase enzyme family
      0.002   17.8   0.1     0.0045   16.6   0.0    1.5  2  PIP49_C         Protein-kinase domain of FAM69
     0.0021   17.5   0.2     0.0034   16.8   0.2    1.2  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.017   14.5   0.0      0.021   14.1   0.0    1.2  1  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  122.1   1.3     1e-38   2.6e-35      25     259 ..       7     248 ..       2     251 .. 0.78

  Alignments for each domain:
  == domain 1  score: 122.1 bits;  conditional E-value: 1e-38
                 EEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.....SSEEEEEEE--TTEBHHHHHH.HHSS--HH...HHHHHHHHHHHHHHHH CS
     Pkinase  25 kivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladlle.rkgslsee...eakkiakqilegleyl 114
                 ++v+vKk+    ++++ +    +  k+l+kl+h+ni+++++  +       + ly+v+e  +++ la++l+ r+++ +++   e+ +i+ q+++g++++
  EFC35686.1   7 EEVVVKKVYDTPETEDFH----ESNKLLQKLDHSNIIKYLDHGKFdspetGEFLYIVTEKGDED-LARYLKeRQTNHANDnlqEMLEIFVQLVRGVAFI 100
                 567788887777776555....6789*************97654444555999*******9966.999999533334444344777999********** PP

                 HHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH....TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHH CS
     Pkinase 115 HskgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl....keneyskkvDvWslGvilyelltgkppfsgekgkekve 207
                 Hs++i HrD+Kp+N+ +  k++ Ki+DF   ++ +++ +    + vgt++Y+AP +     k++  +++ D +slG++l+e++t +  +   +g++ ++
  EFC35686.1 101 HSQNIYHRDIKPANVVVR-KNDWKIIDFEDYAKTDTQDEsiSAQKVGTEYYMAPQICirgcKDRILGNSLDSYSLGCTLLEMITDSSSLT-LNGNTLAY 197
                 ******************.9********75555555555589999***********9998666777*********************999.56666555 PP

                 HHHHTHHHHHHHCT.SHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 208 keldqlekilkilg.etkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                 + +++  +  ++ +   k+  ++    ++++ dl+ +l++k   kRlta+ +l
  EFC35686.1 198 NLVKN--EESDVHNhIRKVIGEKVAMSKQSCGDLVCNLIQKSAAKRLTARCVL 248
                 55555..22333331333344455555899******************98765 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.4   0.4   2.7e-23     7e-20      26     254 ..       4     250 ..       1     255 [. 0.75

  Alignments for each domain:
  == domain 1  score: 71.4 bits;  conditional E-value: 2.7e-23
                  SSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE....SSSS...EEEEEE--TTEBHHHHHHHTCTTTS..BHHHHHHHHHHHHH CS
  Pkinase_Tyr  26 kkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct....keep...llivteyvkgGdLlkfLrkkekekl..tlkdllsfalqvAk 114
                  + +++V+vK++   ++  e+e++ e  k+++kl+h ni+k+l        +  +   l+ivte  +  dL  +L+++++++   +l+++l++ +q+ +
   EFC35686.1   4 QFTEEVVVKKV---YDTPETEDFHESNKLLQKLDHSNIIKYLDHGKfdspE--TgefLYIVTEKGD-EDLARYLKERQTNHAndNLQEMLEIFVQLVR 95 
                  55689999999...6667789********************9888754542..1456999999654.59******9955544227999********** PP

                  HHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHH.HHHSE...EEHHHHHHHHHHHHHHHHTTSSGT... CS
  Pkinase_Tyr 115 GmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEs.lkekk...ftsksDvWsfGvllwEiftlgesp... 205
                  G+++++s+++ Hrd+   Nv+++ ++  ki Df    ++ ++de   + ++     +map + ++ +k   +  + D +s G +l E++t ++s    
   EFC35686.1  96 GVAFIHSQNIYHRDIKPANVVVR-KNDWKIIDFEDYAKTDTQDES-ISAQKVGTEYYMAPQIcIRGCKdriLGNSLDSYSLGCTLLEMITDSSSLtln 191
                  **********************9.5668*****877777444444.444555666789998624433355489999**************88877888 PP

                  .....TTTSHHHH.....HHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHH CS
  Pkinase_Tyr 206 .....ypglknee.....vleklkegkrlekpekcpeelyelmkkcweedpeeRptfse 254
                       y+ +knee      ++k+  +k     ++c + + +l++k+ +++ + R  + +
   EFC35686.1 192 gntlaYNLVKNEEsdvhnHIRKVIGEKVAMSKQSCGDLVCNLIQKSAAKRLTARCVLVS 250
                  99998555544433322244455555666677789999999999999999988877665 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0     0.052   1.3e+02     187     219 ..      52      84 ..      24      86 .. 0.81
   2 !   25.9   0.0   1.5e-09   3.9e-06     303     384 ..      81     154 ..      74     161 .. 0.88
   3 ?   -0.9   0.1       0.2   5.2e+02     208     248 ..     197     242 ..     177     271 .. 0.62

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.052
  Pkinase_fungal 187 EaelLkkaeergvegvarlvahedveekdddia 219
                      +e+L  ++e+g e++ar++++++ ++++d+ +
      EFC35686.1  52 TGEFLYIVTEKGDEDLARYLKERQTNHANDNLQ 84 
                     4799******************99877777665 PP

  == domain 2  score: 25.9 bits;  conditional E-value: 1.5e-09
  Pkinase_fungal 303 espkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaie 384
                     ++ +e+le + + ++g    +  ++i HrDi   N+++       ++ + +iD++ + ++++ + es + +++GT ++ma +
      EFC35686.1  81 DNLQEMLEIFVQLVRGVAFIH-SQNIYHRDIKPANVVVR------KNDWKIIDFEDYAKTDT-QDESISAQKVGTEYYMAPQ 154
                     57899****************.****************9......889******88888885.77777889********965 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.2
  Pkinase_fungal 208 hedveekdddi.aeiRkgldvtkaekfrskrkvvsssssqe....l 248
                     ++ v++++ d+ ++iRk +  + a + +s+ ++v++  +++    l
      EFC35686.1 197 YNLVKNEESDVhNHIRKVIGEKVAMSKQSCGDLVCNLIQKSaakrL 242
                     4455644444448888888777777777777777776665533330 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.23     6e+02      35     102 ..      18      87 ..       6     104 .. 0.64
   2 !   18.4   0.2   6.4e-07    0.0016     163     196 ..     100     130 ..      60     136 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.23
                 HHHHHHHHHHHHHHHTT-.B--B-CTTB.S-EEETTEEEEEEE----EE-SSHHHHHHHHHHHHHHHHHH CS
         APH  35 eeirrevallrlLakagv.pvPevlagd.tddeeigllfalieyvpgrsllrklsaaqlpellealgefl 102
                 +e+++++++ +lL+k++   + + l+ +  d  e g   ++++  + ++l+r+l ++q+ ++ ++l e+l
  EFC35686.1  18 PETEDFHESNKLLQKLDHsNIIKYLDHGkFDSPETGEFLYIVTEKGDEDLARYLKERQTNHANDNLQEML 87 
                 3455555555555555444556777655467777777777777778888888777777777777776666 PP

  == domain 2  score: 18.4 bits;  conditional E-value: 6.4e-07
                 SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 163 elptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                   ++ + H+D++p N++v+++d++   +iDfed 
  EFC35686.1 100 IHSQNIYHRDIKPANVVVRKNDWK---IIDFEDY 130
                 5566788************99999...8****95 PP

>> PIP49_C  Protein-kinase domain of FAM69
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   1.8e-06    0.0045      35     141 ..      59     161 ..      53     167 .. 0.81
   2 ?   -2.5   0.0       1.3   3.4e+03      22      34 ..     218     230 ..     196     256 .. 0.60

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.8e-06
     PIP49_C  35 vveklgalkllek.srslsqflkspwekrakialqlLelveelenndpdslylcdvslenfgvsddgrlkliDldnvfiedkleeklseqkcekdedcs 132
                 v+ek +   l +  +++  +  +++ ++ ++i +ql   v  +++   +++y  d+++ n+ v+++ + k+iD+++ +  d+ +e++s qk  ++    
  EFC35686.1  59 VTEKGD-EDLARYlKERQTNHANDNLQEMLEIFVQLVRGVAFIHS---QNIYHRDIKPANVVVRKN-DWKIIDFEDYAKTDTQDESISAQKVGTEYYMA 152
                 444444.23333343333467799999***********9999999...88*************999.********************999998887777 PP

     PIP49_C 133 ffdclskcd 141
                  + c+  c+
  EFC35686.1 153 PQICIRGCK 161
                 788888886 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.3
     PIP49_C  22 pfpkllGaCGrly 34 
                  ++    +CG+l+
  EFC35686.1 218 KVAMSKQSCGDLV 230
                 4444455677664 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.2   1.3e-06    0.0034      95     168 ..      59     129 ..      56     143 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.3e-06
         Kdo  95 lterlegaqdLedllakwae.laeelkrallk...avgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldk 168
                 +te+  g +dL+ +l++ ++  a+   +++l+   ++ r +a +h+ +++H+d+ + n+ +++++       +iD++ 
  EFC35686.1  59 VTEK--GDEDLARYLKERQTnHANDNLQEMLEifvQLVRGVAFIHSQNIYHRDIKPANVVVRKND-----WKIIDFED 129
                 5664..6689*****9977784444445444422278888899********************98.....88999985 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   8.4e-06     0.021     127     197 ..      67     136 ..      55     220 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 8.4e-06
  Kinase-like 127 lnkvlqkrsethkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtk 197
                  l   l++r+++h++ +    l + +ql+r +a ++++ + h ++++ n++   k   ++ +f+   +  t+
   EFC35686.1  67 LARYLKERQTNHANDNLQEMLEIFVQLVRGVAFIHSQNIYHRDIKPANVVVR-KNDWKIIDFEDYAKTDTQ 136
                  6778999****9999999999999************************9975.456777777777766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       621  (0.0346366); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 1749.66
//
Query:       EFC35687.1  [L=275]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0089   16.5   0.1      0.015   15.8   0.1    1.5  1  DUF1801   Domain of unknown function (DU1801)


Domain annotation for each model (and alignments):
>> DUF1801  Domain of unknown function (DU1801)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.1   8.1e-07     0.015      18      78 ..     107     247 ..      74     252 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 8.1e-07
                 TSEEEEETTEEEEEE...................................................................-.....SSEEEE..... CS
     DUF1801  18 eveesikwgmpfYty...................................................................a.....kkhvslffkGa 44 
                  + e+ik  +p+Y++                                                                   +     kk +sl+++ +
  EFC35687.1 107 ALVEKIKTEQPHYSVecisfipkygdlqidiaktfyicehfetlsfdlieqiklnekfimdiqaslgenngnssliyptseeKfdkstKKEMSLYVNRS 205
                 689****************************999999999999999999999999888888888877777766666666555055666******99977 PP

                 ...........HHTHHHHHH.-EEESSEEEEETTS---HHHHHH CS
     DUF1801  45 k..........edpkgllegkkgkgkrcirfkslddideellee 78 
                 +          + +++ l   ++++kr i+fk++++i e  + +
  EFC35687.1 206 EsefsyhtlilDACSSNLFT-YDTKKRKIHFKDAQKIKEL-ILK 247
                 79865554444455555555.*************999654.334 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       687  (0.0383178); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 2045.79
//
Query:       EFC35688.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00025   21.1   0.9     0.0005   20.1   0.9    1.5  1  MIT            MIT (microtubule interacting and transport) do
  ------ inclusion threshold ------
       0.18   11.6   0.1        1.2    9.1   0.0    2.2  2  Cys_rich_CPCC  Cysteine-rich CPCC
       0.39   10.8   3.3        1.2    9.3   0.1    2.7  3  BACK           BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.9   8.4e-08    0.0005       9      55 ..      15      59 ..      12      68 .. 0.88

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 8.4e-08
         MIT  9 kkAveeDnagnyeeAlelYkealelLlqalkekneerrellrekiee 55
                ++A+++D++ n++eAl+ Y  ++  L q+lk  +++  e l++++++
  EFC35688.1 15 SEAIKRDEQRNFSEALKQYGACMLSLGQLLK--EDNLAEELKSNAQT 59
                79*****************************..66789999888876 PP

>> Cys_rich_CPCC  Cysteine-rich CPCC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.28   1.7e+03      53      63 ..      29      39 ..       6      48 .. 0.75
   2 ?    9.1   0.0   0.00019       1.2       9      46 ..      58      96 ..      56     100 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.28
  Cys_rich_CPCC 53 nfkkfGaceee 63
                     k++Gac  +
     EFC35688.1 29 ALKQYGACMLS 39
                   34789999755 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00019
  Cys_rich_CPCC  9 ltleeeegsydiCpvCfWe.dDlvqlkapdleggaNkvs 46
                   +t+++ + + +iC++Cf    D v+ + p+ ++g N+++
     EFC35688.1 58 QTFKQVSQALKICKMCFERvSDIVDKEIPNSSSGGNTLT 96
                   6888888999*******8779***************876 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1     0.061   3.6e+02      11      52 ..      44      84 ..      35      90 .. 0.74
   2 ?   -2.3   0.0      0.81   4.8e+03       2      26 ..     274     298 ..     273     302 .. 0.74
   3 ?    9.3   0.1    0.0002       1.2       3      46 ..     317     360 ..     315     366 .. 0.94

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.061
        BACK 11 ysceeLaeaakefilknfeevlkseeFleLskeqllellssd 52
                ++ ++Lae  k+   + f++v++     ++ +e++ ++++++
  EFC35688.1 44 LKEDNLAEELKSN-AQTFKQVSQALKICKMCFERVSDIVDKE 84
                5555666665554.5789999999999999999999999876 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.81
        BACK   2 lgilefAeaysceeLaeaakefilk 26 
                 +++l ++++y +++L++ ++ +i +
  EFC35688.1 274 ISLLTLSNKYMISSLSSICELYIAS 298
                 5667788888888888888888765 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.0002
        BACK   3 gilefAeaysceeLaeaakefilknfeevlkseeFleLskeqll 46 
                  i+e++e+y+  +L++++     ++++e+ k+ ++++ + ++l+
  EFC35688.1 317 TIFEISETYQALQLQKVVLYSFASHLKEIKKDPQWKTFPYKELV 360
                 699*************************************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       957  (0.0533772); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2158.38
//
Query:       EFC35689.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0072   16.0   0.7      0.012   15.3   0.7    1.3  1  PNK3P            Polynucleotide kinase 3 phosphatase
  ------ inclusion threshold ------
      0.045   13.6   1.4      0.076   12.9   0.1    2.0  2  DUF3173          Domain of unknown function (DUF3173)
       0.63   10.1   4.2        2.1    8.5   4.1    1.9  1  PTPlike_phytase  Inositol hexakisphosphate


Domain annotation for each model (and alignments):
>> PNK3P  Polynucleotide kinase 3 phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.7     2e-06     0.012      19      79 ..     102     163 ..      94     176 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 2e-06
       PNK3P  19 efakdaddwkllses..vlekLkklkeegykivifsNqggvvekktkkslekfkekieallke 79 
                 + ++  ++wkl+++s  v++ +kkl e + +  if Nq+  + k+ kk++ ++ ++ +++++e
  EFC35689.1 102 VKNEMMEEWKLMKPShvVKKAIKKL-EREGEFTIFDNQEIELPKECKKRIVTWENQARQIIRE 163
                 3344689******999455555555.55557799*****99999************9999986 PP

>> DUF3173  Domain of unknown function (DUF3173)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1      0.32   1.9e+03      32      40 ..     116     138 ..      96     146 .. 0.49
   2 ?   12.9   0.1   1.3e-05     0.076      15      42 ..     154     181 ..     153     183 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.32
     DUF3173  32 k..............GysfYnnk 40 
                                 +++++n+
  EFC35689.1 116 ShvvkkaikkleregEFTIFDNQ 138
                 03333333334444345666666 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 1.3e-05
     DUF3173  15 ehtArdiIrqaKkilVkkGysfYnnkrl 42 
                 e +Ar+iIr+aKk+  + + s +n+ r+
  EFC35689.1 154 ENQARQIIREAKKYEQTGSLSSFNSYRI 181
                 689**********999999999998887 PP

>> PTPlike_phytase  Inositol hexakisphosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   4.1   0.00035       2.1      27      84 ..      83     157 ..      74     184 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00035
                      TT--.HHHHHHHHHHHHHHHHT-SEEEEEEEHHHHHTT-CCG-EE.................E-S-......... CS
  PTPlike_phytase  27 nlkeytgisaeeleklearlkeevlaeakksegrvlvhdeteegk.................dvktlqevweeve 84 
                       l+ y++ ++e l ++e+++k+e+++e k  ++  +v++  ++ +                 ++k+ +  we+  
       EFC35689.1  83 YLECYDEERNEGLRNIEKQVKNEMMEEWKLMKPSHVVKKAIKKLEregeftifdnqeielpkECKKRIVTWENQA 157
                      555688999999****************99999999999999888887665554444433333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1292  (0.072062); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.43u 0.31s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1237.94
//
Query:       EFC35690.1  [L=120]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.1e-10   39.5   9.5    7.7e-10   38.9   9.5    1.3  1  zf-RING_2      Ring finger domain
    9.1e-09   35.0   5.5    1.5e-08   34.3   5.5    1.4  1  zf-C3HC4_2     Zinc finger, C3HC4 type (RING finger)
    8.4e-08   32.0   5.4    1.7e-07   31.0   5.4    1.5  1  zf-C3HC4       Zinc finger, C3HC4 type (RING finger)
    1.1e-07   32.0  10.1    5.9e-07   29.7  10.1    2.1  1  zf-rbx1        RING-H2 zinc finger domain
      4e-07   29.6   4.6      4e-07   29.6   4.6    2.2  2  zf-RING_11     RING-like zinc finger
      8e-06   25.8   5.7    0.00017   21.5   1.8    2.3  2  zf-RING_UBOX   RING-type zinc-finger
    4.1e-05   23.4   5.4    7.2e-05   22.6   5.4    1.4  1  zf-C3HC4_3     Zinc finger, C3HC4 type (RING finger)
    0.00012   22.0   5.1    0.00025   21.1   5.2    1.6  1  zf-ANAPC11     Anaphase-promoting complex subunit 11 RING-H2 
     0.0018   18.4   9.7      0.064   13.4   9.7    2.4  1  FANCL_C        FANCL C-terminal domain
  ------ inclusion threshold ------
      0.013   15.5   6.1       0.03   14.3   6.1    1.7  1  zf-RING_5      zinc-RING finger domain
      0.013   15.1   7.0      0.022   14.3   7.0    1.4  1  Zn_ribbon_17   Zinc-ribbon, C4HC2 type
      0.016   15.0   5.0      0.016   15.0   5.0    1.7  2  zf-RING_4      RING/Ubox like zinc-binding domain
      0.017   15.0   6.0      0.065   13.1   6.0    1.9  1  Prok-RING_4    Prokaryotic RING finger family 4
      0.025   14.2   0.7        6.6    6.4   0.1    2.6  3  Sgf11          Sgf11 (transcriptional regulation protein)
      0.047   13.6   6.1        2.6    8.0   1.7    2.3  2  Prok-RING_1    Prokaryotic RING finger family 1
       0.13   12.4   0.0       0.22   11.7   0.0    1.3  1  U-box          U-box domain
       0.17   12.2   6.0       0.47   10.7   6.0    1.9  1  zf-LITAF-like  LITAF-like zinc ribbon domain
       0.23   11.3   6.2       0.47   10.3   6.2    1.5  1  zf-Nse         Zinc-finger of the MIZ type in Nse subunit
       0.29   11.3   8.3       0.12   12.6   2.2    2.2  2  zf-C3HC4_4     zinc finger of C3HC4-type, RING
       0.34   10.7   5.8        7.6    6.4   1.6    2.3  2  YacG           DNA gyrase inhibitor YacG
       0.93    9.4   4.6        1.9    8.4   4.6    1.6  1  zf-RING_6      zf-RING of BARD1-type protein
        1.2    9.3  11.0         10    6.4  11.1    2.3  1  RINGv          RING-variant domain
        1.5    9.2  12.2        9.3    6.6   4.7    3.1  2  zf-Di19        Drought induced 19 protein (Di19), zinc-bindin
        1.8    8.9   9.3        4.2    7.8   9.3    1.7  1  zf-RING-like   RING-like domain


Domain annotation for each model (and alignments):
>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.9   9.5     1e-12   7.7e-10       2      44 .]      35      79 ..      34      79 .. 0.89

  Alignments for each domain:
  == domain 1  score: 38.9 bits;  conditional E-value: 1e-12
   zf-RING_2  2 eCpICleelssadsvlllp.CgHvfhreClerwlrssst.CPlCr 44
                +C+ICle+l+ ++ +   p C+H fh eC+e+wl+   + CP+C+
  EFC35690.1 35 TCSICLEDLEVGSFASEIPfCNHKFHTECIEKWLKDYGHtCPVCK 79
                7********99998886656*************9888778****7 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.3   5.5     2e-11   1.5e-08       2      40 .]      36      78 ..      35      78 .. 0.90

  Alignments for each domain:
  == domain 1  score: 34.3 bits;  conditional E-value: 2e-11
  zf-C3HC4_2  2 CpiCldmlkdpsvvt...pCgHvfCqkCilrsLeekn.eCPlC 40
                C iCl+ l+ +s       C+H+f+ +Ci ++L++    CP+C
  EFC35690.1 36 CSICLEDLEVGSFASeipFCNHKFHTECIEKWLKDYGhTCPVC 78
                *********9977665658****************999***** PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   5.4   2.2e-10   1.7e-07       1      41 []      36      78 ..      36      78 .. 0.95

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 2.2e-10
                -TTT-S--SS-E....E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4  1 CpiCleeakepn...elleCkHsfCskCirkilksrkkvkCPlC 41
                C+iCle ++  +   e+  C+H+f+++Ci+k+lk +   +CP+C
  EFC35690.1 36 CSICLEDLEVGSfasEIPFCNHKFHTECIEKWLK-DYGHTCPVC 78
                ***********99989999***************.88899**** PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7  10.1   7.9e-10   5.9e-07      28      55 .]      51      79 ..      27      79 .. 0.74

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 7.9e-10
     zf-rbx1 28 vlGeCgHaFHlhCiskWlkt.rkvCPlcr 55
                 +  C+H+FH++Ci+kWlk   ++CP+c+
  EFC35690.1 51 EIPFCNHKFHTECIEKWLKDyGHTCPVCK 79
                4446****************8889****6 PP

>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6   4.6   5.4e-10     4e-07       2      29 .]      36      64 ..      35      64 .. 0.93
   2 ?    1.0   0.1      0.49   3.7e+02       2      11 ..      75      84 ..      75      90 .. 0.87

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 5.4e-10
  zf-RING_11  2 CsICLeefkpgqalfilp.CsHtFHfkCI 29
                CsICLe++++g      p C+H FH +CI
  EFC35690.1 36 CSICLEDLEVGSFASEIPfCNHKFHTECI 64
                ************8887777*********9 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.49
  zf-RING_11  2 CsICLeefkp 11
                C +C +e+++
  EFC35690.1 75 CPVCKQEVTE 84
                99**999986 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   1.8   2.3e-07   0.00017       1      33 [.      36      69 ..      36      74 .. 0.83
   2 ?    6.1   0.1     0.016        12       1       9 [.      75      83 ..      75      95 .. 0.83

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 2.3e-07
  zf-RING_UBOX  1 CpIClelft.......dPlvlpCGHtFCreCl..welsksle 33
                  C+ICle+++        P +  C H F+ eC+  w     l+
    EFC35690.1 36 CSICLEDLEvgsfaseIP-F--CNHKFHTECIekW-----LK 69
                  ********9999999999.7..**********433.....33 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.016
  zf-RING_UBOX  1 CpIClelft 9 
                  Cp+C+++ t
    EFC35690.1 75 CPVCKQEVT 83
                  *****9876 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   5.4   9.7e-08   7.2e-05       2      49 ..      33      84 ..      32      85 .. 0.85

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 9.7e-08
                GSB-TTTSSSBS-EEETT....EEEEEE-HHHHHHHHH.TT-B-TTT--B--E CS
  zf-C3HC4_3  2 deeCviClerprnvvllp....CgHlvlCeeCaekllk.rkkkCpiCrrpiek 49
                + +C+iCle  +   +      C+H  +  eC ek+lk   ++Cp+C++++++
  EFC35690.1 33 ECTCSICLEDLEVGSFASeipfCNHK-FHTECIEKWLKdYGHTCPVCKQEVTE 84
                568******9666666544669****.9*********99***********987 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   5.2   3.3e-07   0.00025      50      82 ..      53      83 ..      26      86 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 3.3e-07
                BTTS-EEEHHHHHHHHHHHSTSSB-TTTSSB-- CS
  zf-ANAPC11 50 Gkckhnfhlhcilkwletetskglcpmcrqtfk 82
                  c+h+fh+ ci kwl+       cp+c+q+++
  EFC35690.1 53 PFCNHKFHTECIEKWLKDYG--HTCPVCKQEVT 83
                46**************9765..68******875 PP

>> FANCL_C  FANCL C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   9.7   8.6e-05     0.064       2      46 ..      33      73 ..      30      87 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 8.6e-05
                --S-SSS--SS-TT-----B--S-TT----B-SGGGHHHHHHHHS CS
     FANCL_C  2 eveCgiCyayrldsgevpdisCdnekCnkkfHsaCLkeWlrslke 46
                e  C+iC+       ev   + + + Cn+kfH++C++ Wl+   +
  EFC35690.1 33 ECTCSICLEDL----EVGSFASEIPFCNHKFHTECIEKWLKDYGH 73
                56799997543....69999999*****************98654 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   6.1     4e-05      0.03       2      44 .]      36      80 ..      34      80 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 4e-05
   zf-RING_5  2 CnkCfekl.skeekfyltsCgHifCekClkkll.ekeavCpiCrk 44
                C++C e l  ++ +  +  C H f+ +C+ k l    ++Cp+C++
  EFC35690.1 36 CSICLEDLeVGSFASEIPFCNHKFHTECIEKWLkDYGHTCPVCKQ 80
                9*******43333466778************9988899*****97 PP

>> Zn_ribbon_17  Zinc-ribbon, C4HC2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   7.0     3e-05     0.022       4      47 ..      33      77 ..      30      84 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3e-05
  Zn_ribbon_17  4 lksCayC..elavkgrvvlcgvCeHvlHasCarewfenddlaeCps 47
                    +C++C  +l+v       + C+H  H++C+++w++    + Cp+
    EFC35690.1 33 ECTCSICleDLEVGSFASEIPFCNHKFHTECIEKWLKDYG-HTCPV 77
                  5689999656777777777899*************99888.89997 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.2      0.52   3.9e+02      19      26 ..      33      40 ..      30      45 .. 0.68
   2 ?   15.0   5.0   2.1e-05     0.016       1      46 [.      36      81 ..      36      83 .. 0.93

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.52
   zf-RING_4 19 eCgyqiCl 26
                eC + iCl
  EFC35690.1 33 ECTCSICL 40
                56666665 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 2.1e-05
   zf-RING_4  1 cplCdeeldetdkdlkpCeCgyqiClfCyhrileeeegrCPaCree 46
                c +C e+l+    +     C++++   C ++ l++ +  CP C++e
  EFC35690.1 36 CSICLEDLEVGSFASEIPFCNHKFHTECIEKWLKDYGHTCPVCKQE 81
                8899999999998999999*************************96 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   6.0   8.7e-05     0.065       1      41 [.      36      83 ..      34      87 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 8.7e-05
  Prok-RING_4  1 CvlCgeq....ekkailepCgHlvCkeCfdsk..dls.sCPlCqrris 41
                 C +C e          +  C+H +  eC +++  d+  +CP+C++++ 
   EFC35690.1 36 CSICLEDlevgSFASEIPFCNHKFHTECIEKWlkDYGhTCPVCKQEVT 83
                 7777777444333334555*************766659*******986 PP

>> Sgf11  Sgf11 (transcriptional regulation protein)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0     0.016        12       3      21 ..      32      50 ..      30      50 .. 0.88
   2 ?    6.4   0.1    0.0089       6.6       5      14 ..      73      82 ..      70      84 .. 0.88
   3 ?   -2.5   0.0       5.4     4e+03      12      19 ..     107     114 ..     106     114 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.016
                -EEE-TTTSSEEEGGGHHH CS
       Sgf11  3 eyvtCpnCgRqiaasRFAp 21
                + +tC +C  +   + FA+
  EFC35690.1 32 KECTCSICLEDLEVGSFAS 50
                579******9999999996 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0089
                EE-TTTSSEE CS
       Sgf11  5 vtCpnCgRqi 14
                +tCp C++++
  EFC35690.1 73 HTCPVCKQEV 82
                69******99 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 5.4
                 SEEEGGGH CS
       Sgf11  12 RqiaasRF 19 
                 +++  sRF
  EFC35690.1 107 KNVTESRF 114
                 678999*9 PP

>> Prok-RING_1  Prokaryotic RING finger family 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   1.7    0.0035       2.6       3      37 ..      32      66 ..      30      68 .. 0.92
   2 ?    7.6   0.2    0.0048       3.6       2      16 ..      70      84 ..      69      86 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0035
  Prok-RING_1  3 tgkkCpvCgkelkeedDiVvCpeCgtpyHraCyek 37
                 ++  C++C + l+ ++ +   p C   +H +C ek
   EFC35690.1 32 KECTCSICLEDLEVGSFASEIPFCNHKFHTECIEK 66
                 6789***********99999************987 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0048
  Prok-RING_1  2 ytgkkCpvCgkelke 16
                 ++g+ CpvC++e++e
   EFC35690.1 70 DYGHTCPVCKQEVTE 84
                 57899******9876 PP

>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00029      0.22      29      65 ..      62      98 ..      54     103 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00029
                HHHHHHHTT.SSB-TTT-SB--GGGSEE-HHHHHHHH CS
       U-box 29 stiekhllsrdktdPftrepltqdqlipnlelKekId 65
                + iek+l+  ++t+P+ ++ +t+ +      +Ke+++
  EFC35690.1 62 ECIEKWLKDYGHTCPVCKQEVTEIDFNHAKIIKEEVN 98
                67**********************9999999999997 PP

>> zf-LITAF-like  LITAF-like zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   6.0   0.00063      0.47      43      67 ..      50      83 ..       8      86 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00063
  zf-LITAF-like 43 cliPfcv.........dslkdvehyCpnCgallg 67
                     iPfc          ++lkd  h+Cp C++ + 
     EFC35690.1 50 SEIPFCNhkfhtecieKWLKDYGHTCPVCKQEVT 83
                   44566666666666679*************9886 PP

>> zf-Nse  Zinc-finger of the MIZ type in Nse subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   6.2   0.00062      0.47       8      56 ..      30      78 ..      25      79 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00062
                SBXXSB-TTTSSB-SSEEEES...SS--EEEHHHHHHHCTTTS-EE-SCCC- CS
      zf-Nse  8 erislkCPltlqpfeePvtsk...kCpHvFEreaIlelikrkktvkCPvagC 56
                e+ + +C + l+ +e          C+H F  e I++ +k      CPv  C
  EFC35690.1 30 EEKECTCSICLEDLEVGSFASeipFCNHKFHTECIEKWLKDYG-HTCPV--C 78
                6667778888888877654444668**************6555.67***..8 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.4      0.29   2.2e+02      15      23 ..      33      41 ..      31      47 .. 0.77
   2 ?   12.6   2.2   0.00016      0.12      16      42 .]      55      78 ..      52      78 .. 0.93

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.29
  zf-C3HC4_4 15 eCGhsfCls 23
                eC +s+Cl+
  EFC35690.1 33 ECTCSICLE 41
                677888874 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 0.00016
  zf-C3HC4_4 16 CGhsfClsCisslqkepdgeqllCplC 42
                C h f  +Ci+++ k+    +++Cp+C
  EFC35690.1 55 CNHKFHTECIEKWLKDY---GHTCPVC 78
                **************998...589**** PP

>> YacG  DNA gyrase inhibitor YacG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   1.6      0.01       7.6       2      28 ..      35      61 ..      34      71 .. 0.81
   2 ?    6.3   0.1     0.011       7.9       2      11 ..      74      83 ..      73      91 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.01
        YacG  2 kCPtCkkevewseenpfrPFCSeRCkl 28
                +C +C ++ e+ +  +  PFC ++  +
  EFC35690.1 35 TCSICLEDLEVGSFASEIPFCNHKFHT 61
                799******************988655 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.011
        YacG  2 kCPtCkkeve 11
                +CP+Ck+ev+
  EFC35690.1 74 TCPVCKQEVT 83
                7******996 PP

>> zf-RING_6  zf-RING of BARD1-type protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   4.6    0.0025       1.9       6      48 ..      32      80 ..      27      94 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0025
   zf-RING_6  6 kllrcsrctdilrep...vclggcehifcsncisdc...fgsgcpvcyt 48
                k   cs c + l        +  c+h f ++ci      +g  cpvc  
  EFC35690.1 32 KECTCSICLEDLEVGsfaSEIPFCNHKFHTECIEKWlkdYGHTCPVCKQ 80
                55566666655543311033567**********8643338*******75 PP

>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4  11.1     0.014        10      20      48 .]      55      78 ..      28      80 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.014
                -STCCCSB-HHHHHHHHHHTCT-SB-TTT CS
       RINGv 20 CrGslklvHesClekWldekeantqCeiC 48
                C   ++ +H +C+ekWl+     ++C +C
  EFC35690.1 55 C---NHKFHTECIEKWLKD--YGHTCPVC 78
                4...4689**********9..77889999 PP

>> zf-Di19  Drought induced 19 protein (Di19), zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.7     0.042        32      28      41 ..      30      43 ..      16      52 .. 0.81
   2 ?    6.6   4.7     0.012       9.3       6      46 ..      53      87 ..      49      94 .. 0.65

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.042
     zf-Di19 28 eskevvCPvCaekv 41
                e+ke+ C++C e +
  EFC35690.1 30 EEKECTCSICLEDL 43
                67899*****8765 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.012
     zf-Di19  6 PyCgkeltvkeLveHvedeHrveskevvCPvCaekvtkdlv 46
                P+C+++++++ + + ++d        + CPvC+++vt+  +
  EFC35690.1 53 PFCNHKFHTECIEKWLKD------YGHTCPVCKQEVTEIDF 87
                566666555555555444......56789999999987333 PP

>> zf-RING-like  RING-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   9.3    0.0056       4.2      19      43 .]      55      78 ..      30      78 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0056
  zf-RING-like 19 CnvrlHvdCfqhyirthsskkCpkC 43
                  Cn ++H +C+++ + +   ++Cp C
    EFC35690.1 55 CNHKFHTECIEKWL-KDYGHTCPVC 78
                  99************.88889***** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (120 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1055  (0.0588432); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              24  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.48
# Mc/sec: 744.56
//
Query:       EFC35691.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.8e-08   33.1   0.0      2e-07   31.1   0.0    1.9  1  tRNA_edit    Aminoacyl-tRNA editing domain
  ------ inclusion threshold ------
       0.11   12.5   0.1        4.3    7.4   0.0    2.2  2  NADH_u_ox_C  C-terminal of NADH-ubiquinone oxidoreductase 21 


Domain annotation for each model (and alignments):
>> tRNA_edit  Aminoacyl-tRNA editing domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.1   0.0   2.2e-11     2e-07      20      98 ..      57     133 ..      31     195 .. 0.79

  Alignments for each domain:
  == domain 1  score: 31.1 bits;  conditional E-value: 2.2e-11
   tRNA_edit  20 aiaKtlvlkdkkge..lvlvllpgdreldlkklakllg..akklrlaseeelrellgvepGgvgPlglkaagvpvllDeslke 98 
                 +++K+ +l  kk++   +  ++  d+++ +++l+k lg  + +lr+a+ +el ++l++ pG+v+Pl+ +      ll +++ e
  EFC35691.1  57 KLCKNFFLNHKKKKqnKFYGVACTDTQVEMNALSKNLGlgSGNLRFADSAELTNYLDILPGNVTPLAFH------LLHPKVQE 133
                 459999999955555678888889*************98669*************************99......44444444 PP

>> NADH_u_ox_C  C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1     0.011        99      11      54 ..      26      68 ..      19      91 .. 0.74
   2 ?    7.4   0.0   0.00048       4.3      31      73 ..     164     206 ..     139     214 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.011
  NADH_u_ox_C 11 gklpYkenesvLddrlkdvanRnsqysalllailPWFnlayhpy 54
                  ++ Y+ ++ ++dd lk v  R     ++ + +   F l +h++
   EFC35691.1 26 ADTSYHAQSDTVDDWLKAVEGRYVDSDQVKFKLCKNFFL-NHKK 68
                 5678****************9998888888888777744.4444 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.00048
  NADH_u_ox_C  31 nRnsqysalllailPWFnlayhpyhgvdlkkYYenregeeewg 73 
                   R+s+  +++l   P  n+a     + +  kY ++  ge++w 
   EFC35691.1 164 LRKSKEFTTMLLFHPLHNCASTSMSQDEFIKYMKECLGEDAWM 206
                  6999999**********************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       555  (0.0309554); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.24s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 1630.53
//
Query:       EFC35692.1  [L=336]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.4e-15   56.2   8.1    1.3e-14   54.3   8.1    1.8  1  DDE_Tnp_1_7  Transposase IS4
  ------ inclusion threshold ------
       0.07   13.0   0.0       0.07   13.0   0.0    1.7  2  DUF4811      Domain of unknown function (DUF4811)


Domain annotation for each model (and alignments):
>> DDE_Tnp_1_7  Transposase IS4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.3   8.1   1.4e-18   1.3e-14       1     186 [.     111     313 ..     111     324 .. 0.90

  Alignments for each domain:
  == domain 1  score: 54.3 bits;  conditional E-value: 1.4e-18
  DDE_Tnp_1_7   1 spvelFelflpdkilerivkatNayakqk...........................kkwleltaeElkaFlGllllmglvr.lpsvedyWstkd..fy 68 
                  +p  +F+++++++i + ++k++N++ + +                           + +++++++++k+Fl ll+  g+ + + ++ d+W+  +   +
   EFC35692.1 111 TPLSMFSKIFTPEIEKYLLKQMNERRRHRiearsekgkrgrpltkndqksrdnylkRFNKPFKKKDFKTFLCLLFKLGNGEkRTKIVDCWRMPTvdAT 208
                  6999*********************9988*************************************************98768889*****9885522 PP

  DDE_Tnp_1_7  69 g.npllseiMsreRFeeilsalhladnstkkaekdklkkvrelidslnermqkvyrpsqtlvldeslv.lfkgrvpfkqylpgkprkvgiklhvlcds 164
                  g    +++ M++ +F e +++l+++ +               + +++n++ ++vy+p++ l++des+v     + p ++++p+kp k+g kl++++d 
   EFC35692.1 209 GdGLFFKSRMKYHKFAEMAACLKFDFD--------------VVESFFNKNSKEVYQPGTVLAFDESMVgMMMRNNPHHVFMPKKPEKNGCKLYTIAD- 291
                  245789******************992..............24589**********************6556899**********************. PP

  DDE_Tnp_1_7 165 qtgyilalelyegearnlrlsr 186
                  ++g+++  +l +++ +++++++
   EFC35692.1 292 KNGFLVYAQLMKRTMEEPEDPA 313
                  **********999988887654 PP

>> DUF4811  Domain of unknown function (DUF4811)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.5      0.54   4.8e+03      29      42 ..       8      21 ..       2      27 .. 0.44
   2 ?   13.0   0.0   7.8e-06      0.07      20      64 ..     262     304 ..     253     308 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.54
     DUF4811 29 dHfGmkkvtttktq 42
                +H+  +++++++tq
  EFC35692.1  8 QHTTQTTQVNNNTQ 21
                33333333333333 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 7.8e-06
     DUF4811  20 vllivandsdHfGmkkvtttktqkiysaadskdlglllyqeiGtk 64 
                 v +++ n  +H +m k+ +++  k+y++ad++  g+l+y+++ ++
  EFC35692.1 262 VGMMMRNNPHHVFMPKKPEKNGCKLYTIADKN--GFLVYAQLMKR 304
                 346778999**********************8..9****998764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1090  (0.0607954); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2051.01
//
Query:       EFC35693.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-19   69.9   0.7    2.8e-19   69.2   0.7    1.4  1  CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) a
    6.5e-10   39.5   0.8    8.2e-10   39.1   0.8    1.2  1  Histone        Core histone H2A/H2B/H3/H4
  ------ inclusion threshold ------
      0.018   15.1   0.1      0.024   14.8   0.1    1.2  1  CENP-T_C       Centromere kinetochore component CENP-T histon
       0.03   13.9   0.3      0.037   13.6   0.3    1.2  1  DUF3919        Protein of unknown function (DUF3919)
      0.038   14.5   1.5       0.71   10.4   0.3    2.1  2  FolB           Dihydroneopterin aldolase


Domain annotation for each model (and alignments):
>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.2   0.7   7.7e-23   2.8e-19       3      65 .]      37      99 ..      35      99 .. 0.98

  Alignments for each domain:
  == domain 1  score: 69.2 bits;  conditional E-value: 7.7e-23
                   XXHHHHHHHHHCCTTXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF  3 LPiarvkkImksdpdarkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65
                   +P+arv++Imksd d+r+i+++A +l+++++e  ie+la+e+ + + +++rKt+++++++ Av
     EFC35693.1 37 MPVARVRRIMKSDADVRTISQEAVVLVSKAAEKLIEHLARESLKNTIRDNRKTVNYNDLSEAV 99
                   8***********************************************************997 PP

>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1   0.8   2.3e-13   8.2e-10      60     129 ..      32     100 ..      15     102 .. 0.93

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 2.3e-13
                 XXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXSEEXHHHHHHHHH CS
     Histone  60 lliqklpfaRvvreivksekedlrisaeavlalqealEallvelfeeAnllakhaKRvTitpkDiqlArr 129
                 ++i   p+aR vr i+ks+ +   is+eav+++ +a+E l+++l+ e+ + +++ +R+T++  D+  A++
  EFC35693.1  32 RQIVDMPVAR-VRRIMKSDADVRTISQEAVVLVSKAAEKLIEHLARESLKNTIRDNRKTVNYNDLSEAVK 100
                 678899****.******9************************************************9997 PP

>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.1   6.7e-06     0.024       8      78 ..      37     103 ..      30     122 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 6.7e-06
    CENP-T_C   8 lPaavvkklakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilLmkrqr 78 
                 +P+a v+++    +k+ +  + +++ea+  + ka +k +e ++++    +    RKt++ +D+   +k+q 
  EFC35693.1  37 MPVARVRRI----MKSDADVRTISQEAVVLVSKAAEKLIEHLARESLKNTIRDNRKTVNYNDLSEAVKSQD 103
                 677777765....555667799*********************999999999***********99999985 PP

>> DUF3919  Protein of unknown function (DUF3919)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.3     1e-05     0.037     125     172 ..      57     103 ..      40     114 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1e-05
     DUF3919 125 knkviivdsnnkakklnssdkkllkeeikklkkisdnkelkktlkskk 172
                 ++ v++v++   +k ++   +++lk++i+  +k  ++++l +++ks++
  EFC35693.1  57 QEAVVLVSK-AAEKLIEHLARESLKNTIRDNRKTVNYNDLSEAVKSQD 103
                 455566665.899********************************996 PP

>> FolB  Dihydroneopterin aldolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.3    0.0002      0.71      18      77 ..      26      79 ..      23      87 .. 0.73
   2 ?    4.0   0.1     0.019        69      43      60 ..      85     102 ..      78     126 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.0002
                HHHC-EEEEEEEEEEE-CHHHHHHTTGGGS.S-HHHHHHHHHHHHHSSEES-HHHHHHHHH CS
        FolB 18 ErelkQrvvvdleleldlskaaesddledt.vdYaelakavkelvesssfkllEalaeria 77
                E++++ r +vd+ +       a+  ++ ++  d ++++++++ lv++   kl+E+la++ +
  EFC35693.1 26 EQQQPIRQIVDMPV-------ARVRRIMKSdADVRTISQEAVVLVSKAAEKLIEHLARESL 79
                55555555555555.......44455445549**************99*********8754 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.019
                 TGGGSS-HHHHHHHHHHH CS
        FolB  43 dledtvdYaelakavkel 60 
                 d ++tv+Y +l++avk  
  EFC35693.1  85 DNRKTVNYNDLSEAVKSQ 102
                 557899999999999853 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1283  (0.07156); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 833.07
//
Query:       EFC35694.1  [L=450]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.16   11.9   1.0       0.24   11.2   1.0    1.2  1  FdhE      Protein involved in formate dehydrogenase formation


Domain annotation for each model (and alignments):
>> FdhE  Protein involved in formate dehydrogenase formation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   1.0   1.4e-05      0.24     188     230 ..     298     342 ..     290     350 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 1.4e-05
                 ----EEEEEETTT-..-EEE--TTS-TTT---SS-EEE------C CS
        FdhE 188 eaeglRylhCslCe..teWhvvRvkCsnCeetkelaylsledeka 230
                 ++ + +y +C +C+  + W++v  +C+ C+++ +l y++ ++++a
  EFC35694.1 298 NKLNKKYPSCHVCNkkATWEHVFSECIMCKSELSLLYKKWNESSA 342
                 5667899******83357*******************99887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (450 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 3075.18
//
Query:       EFC35695.1  [L=195]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (195 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       575  (0.0320709); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 1317.58
//
Query:       EFC35696.1  [L=257]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-07   29.5   0.0    7.7e-07   28.8   0.0    1.3  1  Ras       Ras family
  ------ inclusion threshold ------
       0.01   15.8   0.2      0.017   15.1   0.2    1.3  1  NICE-3    NICE-3 protein


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0   8.6e-11   7.7e-07      73     141 ..     147     230 ..     121     246 .. 0.84

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 8.6e-11
                 SEEEEEE...ETTBHHHHHTHHHHHHHHHHHSTTTSEEEEEEETTTGGG...........G-SS-HHHHHHHHHHHT.SEEEEE CS
         Ras  73 egillvy...ditsresfenvkkwveeikrvaeenvpivLvGnKvDlee...........kravsteegeelakelg.lkflet 141
                 +g+llv    d++++  ++++  wv+++++v +++vpivL+Gn +D ++           +  +ste+ge+la++lg ++++e+
  EFC35696.1 147 HGFLLVIdtvDVSENYLLNELPLWVKDLRSVISDSVPIVLIGNNADKRDallstqhkledRLPLSTEQGEKLAEKLGcFTYIEM 230
                 67777752225778888999**************************************97778**************999*997 PP

>> NICE-3  NICE-3 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.2   1.9e-06     0.017      56     142 ..      11     104 ..       5     109 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.9e-06
      NICE-3  56 eierrlelvskikyePrllsesderllelesqeekssysylyRmkavDavreleselesldkklgrhp.......genlrsyLlrlr.ssplksv 142
                  i++ l  v++ +++ +ll e  ++ ++ +++ e+ + ++++Rm  +++v+ le+++++ + +++  +       +++   +L r+  ++ ++ +
  EFC35696.1  11 IIQQDLVDVQQHHHKHKLLLETLRKPIHHHHHDEENNDHHFFRMANIEKVSVLEDKIPKTS-DYEPLSwacfgkcKKSRIDFLSRITnQEVFQAM 104
                 5888999999999999999888444556666669999*********************998.333333466777677777888887766666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       730  (0.0407162); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1718.25
//
Query:       EFC35697.1  [L=167]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       456  (0.0254337); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1051.54
//
Query:       EFC35698.1  [L=311]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.069   13.4   0.4        0.2   12.0   0.4    1.7  1  NES_C_h   Nicking enzyme C-terminal middle helical domain


Domain annotation for each model (and alignments):
>> NES_C_h  Nicking enzyme C-terminal middle helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.4   1.1e-05       0.2      35      82 ..      10      57 ..       5      69 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.1e-05
     NES_C_h 35 nWknStlikkavgedktkqleeiekqeelleeAdellnkeadrlvekl 82
                nWk+S  i+   +++ tk ++++++q++ +   d+ ln+  +  + ++
  EFC35698.1 10 NWKKSSDITAIKKKKPTKRVNIVNNQRDIILDMDDTLNTMPNEGTIQH 57
                9********9999999*********************99887655555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       588  (0.032796); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1900.74
//
Query:       EFC35699.1  [L=268]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.3e-38  131.4   0.0    3.4e-38  130.9   0.0    1.3  1  CRAL_TRIO       CRAL/TRIO domain
    2.3e-08   34.3   0.0    4.1e-08   33.5   0.0    1.4  1  CRAL_TRIO_2     Divergent CRAL/TRIO domain
    3.2e-07   30.4   0.2    6.8e-07   29.4   0.2    1.5  1  CRAL_TRIO_N     CRAL/TRIO, N-terminal domain
  ------ inclusion threshold ------
      0.019   14.4   0.0      0.025   14.0   0.0    1.1  1  GCP_C_terminal  Gamma tubulin complex component C-terminal
      0.045   14.0   0.0      0.095   13.0   0.0    1.5  1  DUF4368         Domain of unknown function (DUF4368)


Domain annotation for each model (and alignments):
>> CRAL_TRIO  CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  130.9   0.0   9.4e-42   3.4e-38       3     159 .]     103     255 ..     101     255 .. 0.96

  Alignments for each domain:
  == domain 1  score: 130.9 bits;  conditional E-value: 9.4e-42
   CRAL_TRIO   3 ileggkvgihgrDkegrpvlylrlgrfdpkklsleelvralvlvlerllkeleedgqvegvtvviDlkglslskmlwkpisllkkilkilqdnyperlg 101
                 + ++gk + +g+Dk++rp++y+ ++r + ++++  + +++lv+++er++++++e  +ve++t +iD++g++ ++ +  p+s++k++l il+++yperlg
  EFC35699.1 103 ESSSGKLFQRGFDKNNRPIIYMFPARENSTDYE--KNIKLLVYTMERAVDAMPE--GVEQMTWIIDFNGYTTRNAP--PFSVAKQTLSILNECYPERLG 195
                 67899***************************9..*******************..***************88888..7******************** PP

   CRAL_TRIO 102 kilivnaPklfkfafklvkpfldektreKikfvspsntea..tlekyidpeqlpkelGGt 159
                  +++v+ P++f+++++ ++pf++++t++Ki+fv++++ e+   + k+id  q+  ++GGt
  EFC35699.1 196 ACFMVDTPFIFNIFWRAISPFINPVTKNKIHFVNGKESEKakIFGKHIDLAQIDTTWGGT 255
                 *********************************99888767799***************7 PP

>> CRAL_TRIO_2  Divergent CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.5   0.0   1.2e-11   4.1e-08       2     124 ..     119     243 ..     118     262 .. 0.77

  Alignments for each domain:
  == domain 1  score: 33.5 bits;  conditional E-value: 1.2e-11
  CRAL_TRIO_2   2 rpVfvfiaafllsskadldkllryvlhtladkivgke.....yvlVyfhtglssenkpslswlkkvystlprrykknlkklyivhpstfvktllktvl 94 
                  rp++++ +a+   +  d++k ++ ++ t+++ +   +     ++ +++ +g +  n p  s++k+++s+l   y+++l + ++v   + + ++   + 
   EFC35699.1 119 RPIIYMFPARE--NSTDYEKNIKLLVYTMERAVDAMPegveqMTWIIDFNGYTTRNAPPFSVAKQTLSILNECYPERLGACFMVDTPFIFNIFW-RAI 213
                  56666554444..23477777777777774443332244567*******************************************999999999.999 PP

  CRAL_TRIO_2  95 safvsskfrkkveyvsrleeLarkidrtql 124
                  s+f  +  ++k+++v+  e  + ki+ +++
   EFC35699.1 214 SPFINPVTKNKIHFVNGKESEKAKIFGKHI 243
                  ***99999******9888777555554443 PP

>> CRAL_TRIO_N  CRAL/TRIO, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4   0.2   1.9e-10   6.8e-07      10      52 ..      42      80 ..      28      82 .. 0.80

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 1.9e-10
  CRAL_TRIO_N 10 qeseyk.lteeekfWltredhddaclLRfLRArkwdvekAikrL 52
                 ++++y  lt++e+ +l +       lLRfLRAr++d++kA k +
   EFC35699.1 42 KKIDYDsLTDRERKYLDEP-----SLLRFLRARDYDLNKAEKLM 80
                 3444449************.....****************9976 PP

>> GCP_C_terminal  Gamma tubulin complex component C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0     7e-06     0.025     159     308 ..      12     168 ..       3     168 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 7e-06
  GCP_C_terminal 159 emlhfvsqlqyYvldeviessWreleekl.kkeatdldelieaHeafLdsilkkclLrskkkllklleeilelileFakvldglylsvselt... 249
                      + +f++  + Y   + + ++ +e ++   k +  d d+l +  +++Ld+     +Lr ++  l+  e++++ +le+++ ++    + +el+   
      EFC35699.1  12 SATSFIDVTKGYNPRTSLTQEQNEILNDFiK-KI-DYDSLTDRERKYLDEPSLLRFLRARDYDLNKAEKLMNSCLEWRRTFKPDEITAKELEdes 104
                     5556666666666665555555555544424.44.59********************9995448999*********9986655333444434667 PP

  GCP_C_terminal 250 ......aeeaeeeeleekleerleelekeFrkkvslllkvlralkeqeededlrqLllrLdfnef 308
                           ++ +++++ +  +    +e +++++k+++ll+ ++++   +   e ++q+   +dfn++
      EFC35699.1 105 ssgklfQRGFDKNNRPIIYMFPARENSTDYEKNIKLLVYTMERA-VDAMPEGVEQMTWIIDFNGY 168
                     889999888888888888889999*****************664.233457************98 PP

>> DUF4368  Domain of unknown function (DUF4368)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   2.6e-05     0.095       9      41 ..      10      45 ..       4      56 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.6e-05
     DUF4368  9 kedvekFlalvrkytdieeLtp...eilnelIekIe 41
                  ++++F+++ + y   + Lt+   eiln++I+kI 
  EFC35699.1 10 MHSATSFIDVTKGYNPRTSLTQeqnEILNDFIKKID 45
                567899**************973336*********6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       643  (0.0358637); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1680.36
//
Query:       EFC35700.1  [L=297]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1258  (0.0701657); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 1636.76
//
Query:       EFC35701.1  [L=106]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0056   15.5   0.6     0.0056   15.5   0.6    1.1  1  LAX       Lymphocyte activation family X


Domain annotation for each model (and alignments):
>> LAX  Lymphocyte activation family X
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.6   3.1e-07    0.0056     263     306 ..      60     103 ..      25     106 .] 0.86

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 3.1e-07
         LAX 263 qccrdyenVppadpngsqqqaeeevtssntdhverrtdglgthv 306
                   c+d+ nV  +d n+++++ e++v + nt+++e+++ ++++h 
  EFC35701.1  60 FICKDDSNVEETDSNKEEKNLEQDVDANNTENQENKSTNPDVHH 103
                 47**********************************99999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (106 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1091  (0.0608511); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.27s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 772.92
//
Query:       EFC35702.1  [L=213]
Description: hypothetical protein NAEGRDRAFT_76639 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.2e-08   33.1   0.0    1.9e-07   31.7   0.0    1.7  1  MJ1316        MJ1316 RNA cyclic group end recognition domain
  ------ inclusion threshold ------
       0.13   11.4   2.4        0.2   10.7   2.4    1.2  1  SprA-related  SprA-related family
        1.4    9.4   7.1         21    5.7   0.1    2.5  2  COX16         Cytochrome c oxidase assembly protein COX16


Domain annotation for each model (and alignments):
>> MJ1316  MJ1316 RNA cyclic group end recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7   0.0   3.1e-11   1.9e-07       3      76 .]      42     110 ..      41     110 .. 0.79

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 3.1e-11
      MJ1316   3 taqdvlnRirWdkeldks..kfvvgyldRfkgikevpleeiswiedflleeeegelaIPlHRiryikrkgevv.WdR 76 
                 t ++ +nRi+Wd++l+ +  + +  y dRf+g   ++ ee+   +d    +ee     P+HRi++  +++e v Wd+
  EFC35702.1  42 TCKEAINRIMWDSDLNDAylHLSMIYKDRFEGDTFISYEEFLN-SD---LAEE----LPQHRIQQLIYRDEYVfWDK 110
                 56789***********9833456789999**********9998.55...2334....9******9888866652665 PP

>> SprA-related  SprA-related family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   2.4   3.4e-05       0.2      93     164 ..     134     205 ..     120     209 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 3.4e-05
  SprA-related  93 saeqanekadfaaifgqeeesasaakekeqqkkdeqsqqerekvaqeqkqkqvfaketqeSnaqqsqeEndi 164
                       a+e+a+f+++ +     +s+ k   q+k++++++  +e v ++++ kq+ ++ +++ + +q  eE d 
    EFC35702.1 134 QERIAREHAEFTTVLQPTTPETSTLKSCSQKKNKKNKKIMKEFVRNQETGKQIVSSIDEDDEYEQYMEEYDE 205
                   456799*********999999*****************************************9999999875 PP

>> COX16  Cytochrome c oxidase assembly protein COX16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.1    0.0035        21      31      67 ..      21      57 ..       9      60 .. 0.84
   2 ?    5.4   2.7    0.0045        27      18      67 ..     158     205 ..     155     209 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0035
       COX16 31 rkvkelskeealelkkkrrkvdleeeyerlqakldld 67
                +k++++ +ee++ lkkk+r ++ +e  +r++ ++dl+
  EFC35702.1 21 SKNEQIAEEETIWLKKKERFLTCKEAINRIMWDSDLN 57
                5799***************99********99887765 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0045
       COX16  18 Lteftqlryevrdrkvkelskeealelkkkrrkvdleeeyerlqakldld 67 
                 L++  q +++++++ +ke  ++++++ k+  + +d+++eye+ +++  ++
  EFC35702.1 158 LKSCSQKKNKKNKKIMKEFVRNQETG-KQIVSSIDEDDEYEQYMEE-YDE 205
                 55556666666666688887777777.5677888**********97.444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1708  (0.0952647); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1326.60
//
Query:       EFC35703.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.18   12.2   0.1       0.37   11.1   0.1    1.5  1  RPN6_N    26S proteasome regulatory subunit RPN6 N-terminal d


Domain annotation for each model (and alignments):
>> RPN6_N  26S proteasome regulatory subunit RPN6 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   2.1e-05      0.37      52      89 ..     191     228 ..     183     238 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 2.1e-05
      RPN6_N  52 eeLaelikesrsflssiaKaKtaKlvrtLldlfskipn 89 
                  +L+++++++ +   s +K K aK++++L+d + ++++
  EFC35703.1 191 GKLKKIFQKVSPSTPSSPKKKRAKVLKNLFDSMPNLTK 228
                 58999**************************9988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       566  (0.031569); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1945.87
//
Query:       EFC35704.1  [L=509]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.8e-17   61.2  20.9    3.5e-08   33.1   0.2    3.1  3  Voltage_CLC  Voltage gated chloride channel


Domain annotation for each model (and alignments):
>> Voltage_CLC  Voltage gated chloride channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.8   0.00028         5     194     260 ..      90     163 ..      78     166 .. 0.67
   2 !   33.1   0.2   1.9e-12   3.5e-08       3      60 ..     157     216 ..     155     217 .. 0.92
   3 !   31.3  10.6   6.7e-12   1.2e-07     277     353 ..     218     296 ..     217     297 .. 0.92

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.00028
                  CHH..CHHHHHHHHHHHHHHHHHHHCCCSC.C..CSSSSCCHHHHHCTT-S-...HHHHHH...HHHHHHHHHH CS
  Voltage_CLC 194 kle..klkikkrlepalvgllvgllglllp.a.svlgggyeliasllegstl...llsllllllllllkllata 260
                   l+  + k++ + ++ ++g++ g++ + +    +++  g  ++ +++++++    +l l++l+ l+++++ +++
   EFC35704.1  90 GLKgiRRKKYTWTFLTVCGFVGGVIIYTHDlIvKYMFQGRLTLINAFDSNSYfglRLVLWILFNLVFMYVSLMM 163
                  3333134445788*************999755779999999999999877546666666666666666554443 PP

  == domain 2  score: 33.1 bits;  conditional E-value: 1.9e-12
                  HHHHHHCCCCC-GGGSC-SHHHHHHHCTTSS--..-HHHHHHHHHHHHHHHHCTT-S-BT CS
  Voltage_CLC   3 gllagllvklvapeaagsGipevkaalngvkgp..lslrvllvkflasvltvgsGlslGr 60 
                  + ++ +++ ++ap ++gsGip +ka+lng+  +  ls++++lvk++++  ++g+G++ G+
   EFC35704.1 157 MYVSLMMTIFIAPASEGSGIPAIKAILNGTPLEdpLSFKTFLVKIITLPAVLGTGMFFGK 216
                  56777889999*******************99999***********************98 PP

  == domain 3  score: 31.3 bits;  conditional E-value: 6.7e-12
                  HHHHHHHHHHHHHHHHH-C....TSSC...HHHHHHCCTHHHHHCCS-HHHHHHHHHHCC--GCCHHHHHHHHHHHHHHHC CS
  Voltage_CLC 277 viGAalGrlvglvlalllp....gaassdpgafalvGmaaflagvtrapltaiviviEltgdlelllplmlavliAkavad 353
                  +iGA  Gr++g+++a+++p      ++   ga+a+vG +a+ a +t+  +++++i +E++g +++ lp ++a+liA  +++
   EFC35704.1 218 IIGAGCGRFFGEIVAIIFPngfvAGQPIYAGAYAVVGIVALTASATH-AFSTVFIFLEIVG-VAVYLPSLMAALIAVRISR 296
                  69*****************99985555677*****************.9************.999999999*****99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (509 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1135  (0.0633053); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 3210.28
//
Query:       EFC35705.1  [L=178]
Description: hypothetical protein NAEGRDRAFT_82355 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.18   11.9   2.7       0.24   11.5   2.7    1.2  1  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe
        1.3    9.0   6.8       0.33   11.0   3.5    1.7  2  DUF5345          Family of unknown function (DUF5345)


Domain annotation for each model (and alignments):
>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   2.7   2.7e-05      0.24      27      95 ..     107     171 ..     102     178 .] 0.66

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.7e-05
  Phage_holin_3_6  27 keeakragsgagllgaagvlallalllllvala...lalaalwlaalivaavllvlagvlalvglkklkkak 95 
                      + ++k+++ g +++++  ++ + ++ ++  +l+   ++l       +i a++ l++a++  ++g+  l k +
       EFC35705.1 107 DNNKKNIMMGCIMFVLVSLFIVSTVYFVKSLLMnniVIL-------TICAIMSLLAALIISVLGIIWLTKHS 171
                      678999999999999999999999888888885332333.......44555555555555555555555544 PP

>> DUF5345  Family of unknown function (DUF5345)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   3.5   3.7e-05      0.33      31      76 ..     107     155 ..     100     156 .. 0.79
   2 ?   -1.0   2.0       0.2   1.8e+03      45      55 ..     152     162 ..     136     170 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 3.7e-05
     DUF5345  31 erkrkrlrrElllFlliAllilsllll...alvqapalfiviQvialia 76 
                  +++k  +   ++F+l++l+i+s + +   +l+++++++ ++ +++l+a
  EFC35705.1 107 DNNKKNIMMGCIMFVLVSLFIVSTVYFvksLLMNNIVILTICAIMSLLA 155
                 57888899999************87652226888888888888888877 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.2
     DUF5345  45 lliAllilsll 55 
                  l+A li+s+l
  EFC35705.1 152 SLLAALIISVL 162
                 34455555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1406  (0.0784204); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.25s 00:00:00.69 Elapsed: 00:00:00.41
# Mc/sec: 1318.01
//
Query:       EFC35706.1  [L=262]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (262 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       766  (0.0427241); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1720.10
//
Query:       EFC35707.1  [L=252]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
        8.9    6.1   9.3        1.3    8.8   0.6    2.5  3  Phage_holin_2_4  Bacteriophage holin family, superfamily II-l


Domain annotation for each model (and alignments):
>> Phage_holin_2_4  Bacteriophage holin family, superfamily II-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1      0.47   8.5e+03       2      25 ..     103     126 ..     103     127 .. 0.70
   2 ?    8.8   0.6   7.2e-05       1.3      29      49 ..     155     175 ..     147     177 .. 0.90
   3 ?    2.6   0.5    0.0064   1.1e+02       5      36 ..     180     212 ..     178     217 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.47
  Phage_holin_2_4   2 KtEtiealaaagnkatggGavvsf 25 
                      K+ ti+  +a+ + +  g + v+f
       EFC35707.1 103 KQVTIQSGSAVNGNTKLGQSQVGF 126
                      566777777887777777777776 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 7.2e-05
  Phage_holin_2_4  29 lasselialvGlavAliGlLv 49 
                      l+s +l+ l+G++v +iGlLv
       EFC35707.1 155 LTSMKLACLLGMLVTVIGLLV 175
                      679999**************9 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.0064
  Phage_holin_2_4   5 tiealaaagnkatgg.GavvsfaGflasselia 36 
                      +i a a+a+ kat +  av+ +     ss+++ 
       EFC35707.1 180 AIAAFATASTKATDIlIAVGKVTSLFESSNAVV 212
                      68899******9976257777888888988886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (252 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1513  (0.0843884); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 1662.25
//
Query:       EFC35708.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-19   70.6   0.0    1.4e-19   70.5   0.0    1.0  1  Pkinase      Protein kinase domain
    4.5e-10   39.2   0.0    5.4e-10   39.0   0.0    1.0  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.5   0.0   1.6e-23   1.4e-19     136     264 .]       7     125 ..       1     125 [. 0.85

  Alignments for each domain:
  == domain 1  score: 70.5 bits;  conditional E-value: 1.6e-23
                 EEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS- CS
     Pkinase 136 elKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseis 234
                 ++ i+DFGlak+ ++s+   s  gt+ Y++PE+l + + ++k+D++slGv+ly++l+  +  s  ++      +l++ e++ +il+e        +  s
  EFC35708.1   7 DIIIADFGLAKNSKQST-SFSLAGTPLYISPELLCGISCDHKTDIFSLGVTLYQILSHDTTTS-INQ----MYMLKDSETVKQILKE----KISLQIYS 95 
                 5789***********98.889*************************************99999.222....3456665677777753....23344559 PP

                 HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 235 eeakdllkkllkkdpkkRltaeellqhpyl 264
                  e+ +l+ ++l+kdp++R+ a ++l+h+y+
  EFC35708.1  96 LELVELVFSMLEKDPERRPDAGSILKHHYF 125
                 *****************************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.0     6e-14   5.4e-10     142     256 ..       8     120 ..       2     123 .. 0.73

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 6e-14
                  EEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGT.TTTS...HHHHHHHHH.HTTEES-BBTTSBHHH CS
  Pkinase_Tyr 142 vkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgesp.ypgl...kneevlekl.kegkrlekpekcpeel 234
                  + i+DfGLa++     +++++ +      +++pE l   ++ +k+D++s Gv+l+ i+++  ++ ++++   k++e+++++ ke+  l+     + el
   EFC35708.1   8 IIIADFGLAKNS----KQSTSFSLAGTPLYISPELLCGISCDHKTDIFSLGVTLYQILSHDTTTsINQMymlKDSETVKQIlKEKISLQI---YSLEL 98 
                  78********98....33344445555669****************************96554333333223555555555244444433...4689* PP

                  HHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 235 yelmkkcweedpeeRptfselv 256
                   el+ + +e+dpe+Rp+  +++
   EFC35708.1  99 VELVFSMLEKDPERRPDAGSIL 120
                  ****************987776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.32s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 899.68
//
Query:       EFC35709.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.5e-07   29.3   0.0    1.2e-06   28.5   0.0    1.4  1  BPL_LplA_LipB  Biotin/lipoate A/B protein ligase family
  ------ inclusion threshold ------
      0.055   13.4   0.0       0.11   12.4   0.0    1.5  1  BPL_C          Biotin protein ligase C terminal domain


Domain annotation for each model (and alignments):
>> BPL_LplA_LipB  Biotin/lipoate A/B protein ligase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5   0.0   1.3e-10   1.2e-06      23     131 .]      54     167 ..      35     167 .. 0.84

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 1.3e-10
                    TT-EEEEEEESS-B....-B--B-TT..SEEEEEEEEESS...-CCGTHHHHHHHHHHHHHHH......HHTT-TTEEEETTTEEEE.......TT CS
  BPL_LplA_LipB  23 sgglvvvrrqtgGr....nvwhspkg..eltyslllspeqktfqnrvlelyvsllvlavlealgyrdskpgiegipvfikwpnDlyv.......ng 105
                    +g+l ++++qt+Gr    + w s++   +l++++++ ++  + q  +l  + + + la++ +l      + +   ++ ikwpnD+ v         
     EFC35709.1  54 TGTLILAEEQTKGRgrrgREWSSAGKgkNLYFTIVFHVRLDNAQ--ELIKLNLAIPLAITITL------RDEGLENCGIKWPNDVWVipnekdsLP 141
                    67899*****************9976589********9997777..44444666677777777......6788889*************9988777 PP

                    EEEEEEEEEEEETTS-EEEEEEEEEE CS
  BPL_LplA_LipB 106 rKlaGiavtstrgktlhhivigvgvn 131
                     K++G ++ s+ ++++     g+g+n
     EFC35709.1 142 SKISGMLIDSVQSGETLFALAGIGIN 167
                    8***********99999999999988 PP

>> BPL_C  Biotin protein ligase C terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.2e-05      0.11      13      35 ..     247     269 ..     234     283 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.2e-05
                 CEEEEEEEEE-TTSEEEEEETTE CS
       BPL_C  13 gkveGiavGIdddGaLllktddg 35 
                  +++++avGI+ +G+L ++  dg
  EFC35709.1 247 PSYTAKAVGISKFGNLMVEMKDG 269
                 5689**************99998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       379  (0.0211389); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1766.12
//
Query:       EFC35710.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-16   59.3   1.0    4.8e-16   58.9   1.0    1.2  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.9   1.0   2.7e-20   4.8e-16      85     157 ..       1      78 [.       1      95 [. 0.90

  Alignments for each domain:
  == domain 1  score: 58.9 bits;  conditional E-value: 2.7e-20
  Guanylate_cyc  85 mlealeevaveskeglkvrvGiht...GpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellk..e 157
                    m+ +++++++++ ++l+vrvGiht   G v+a v+G++k+ yd++G +v +A  me tg +++ ++s++ty++ k  +
     EFC35710.1   1 MITTVNQFSESTGNSLQVRVGIHTsigGDVIAAVVGKVKRTYDLFGSDVKIAQLMEMTGITNELHISNNTYKSIKseK 78 
                    677889999999***********99989*********************************************99431 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       709  (0.0395449); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.35u 0.20s 00:00:00.55 Elapsed: 00:00:00.38
# Mc/sec: 1028.57
//
Query:       EFC35711.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.8e-05   22.4   0.1    0.00015   21.4   0.1    1.5  1  LRR_8         Leucine rich repeat
  ------ inclusion threshold ------
       0.11   12.4   0.0       0.15   12.0   0.0    1.1  1  Phage_Mu_Gam  Bacteriophage Mu Gam like protein


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.1   1.7e-08   0.00015       5      61 .]     123     180 ..     119     180 .. 0.88

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 1.7e-08
                 EEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   5 sLdLsnNr.ltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 sL+L +N+   +l+ +   +l+++++++L  N +    p+     psL+ ++L +N++
  EFC35711.1 123 SLNLARNNlTGVLPTGIADSLQSVMIINLAFNAIGGQIPKEYGEIPSLTGIHLGSNHF 180
                 89******445566677777****************88******************96 PP

>> Phage_Mu_Gam  Bacteriophage Mu Gam like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   1.7e-05      0.15      36      95 ..      42     100 ..      37     110 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.7e-05
                   HHHHCHHHHHHHHHHHHHHHHHHHCTHHHH-..-----EE-SS-EE---------.--TT CS
  Phage_Mu_Gam  36 leaeleplkkeieylesllkqYaeankdeLfkdgktKslklpfGkvgfrkstpkvkkrdk 95 
                   ++  le+ + +i+ l+++l+ +ae+  + L +    +   l +G   +r++t +  ++d+
    EFC35711.1  42 YKRDLEKFQRRIDRLKEQLEFFAESDSEGLSERDFLRKFYLSTGGHYWRNNTGWN-TMDT 100
                   78899*************************9888888999999999999999875.4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1002  (0.0558871); expected 358.6 (0.02)
Passed bias filter:                      616  (0.0343577); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1543.26
//
Query:       EFC35712.1  [L=252]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      6e-16   58.9   1.3    1.7e-15   57.5   1.3    1.8  1  HATPase_c    Histidine kinase-, DNA gyrase B-, and HSP90-like
    7.6e-15   54.7   0.0    1.4e-14   53.8   0.0    1.5  1  HisKA        His Kinase A (phospho-acceptor) domain
  ------ inclusion threshold ------
       0.14   12.0   8.1       0.53   10.1   8.1    2.0  1  HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like
        1.9    8.7  10.5        3.3    7.9   4.4    2.5  2  STT3_PglB_C  STT3/PglB C-terminal beta-barrel domain


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.5   1.3   3.8e-19   1.7e-15       2      83 ..     132     251 ..     131     252 .] 0.71

  Alignments for each domain:
  == domain 1  score: 57.5 bits;  conditional E-value: 3.8e-19
                 HHHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE........................EE.........TEEEEEEEESSSSSTTHHHTGTCSTTCH.... CS
   HATPase_c   2 dekrLrqiisnlvdNavkfatkageieveika........................se.........ddlvisveDnGiGipkedlkklfekfsq.... 63 
                  + rL+q+++nl++Navk+++++g +++++++                        ++         + +++++ DnG+Gipk+ +++lf++f +    
  EFC35712.1 132 ESVRLQQVLINLLTNAVKASNSNGIVTLKVETiedlneinlnnninlnennnnlnnNNlnlnindkkQLVTFKIIDNGKGIPKNVQELLFKPFFSgfin 230
                 689***************955666555544445555555555555554444444430033334444589999***********************9**6 PP

                 .HCSTCHTSTSSSHHHHHHHH CS
   HATPase_c  64 .ddstkrggggtGlGlsivkk 83 
                  + ++k+   gtGlGlsi+kk
  EFC35712.1 231 sSTNSKSAVMGTGLGLSIAKK 251
                 5444444569*********98 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.8   0.0   3.2e-18   1.4e-14       1      67 []      11      76 ..      11      76 .. 0.96

  Alignments for each domain:
  == domain 1  score: 53.8 bits;  conditional E-value: 3.2e-18
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHC..T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH CS
       HisKA  1 slgrflagvaHELrtPLsailgnaeaLkregklteelkeyletiesearrldhlvedlLdlsrieag 67
                s++ ++++++HE+r PL +i+g +e+L ++ klte++ +yl+ti  ++  l+ l+ed+L++s++e g
  EFC35712.1 11 SKNSLVSSISHEFRSPLMSISGCIELLLDT-KLTEDQIQYLKTIGCCSSILLTLIEDILQYSKLEKG 76
                6889***********************996.*********************************976 PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   8.1   0.00012      0.53       4      77 ..     137     246 ..     134     251 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00012
  HATPase_c_3   4 ekAlaelvdNsldAdaen...................................vkievnknrgktgeivieDdGkGmsee..elk.n.alr.latssk 61 
                  +++l+ l+ N++ A+  n                                    ++++n+++ +  +++i D+GkG++++  el  + +++ + +ss+
   EFC35712.1 137 QQVLINLLTNAVKASNSNgivtlkvetiedlneinlnnninlnennnnlnnnnLNLNINDKK-QLVTFKIIDNGKGIPKNvqELLfKpFFSgFINSST 233
                  689999********99999*999999999999999999999999999999988888888765.679************98543321223321333333 PP

  HATPase_c_3  62 eakrkstslGkkGiGl 77 
                  +  +ks ++G  G+Gl
   EFC35712.1 234 N--SKSAVMGT-GLGL 246
                  3..45555553.5554 PP

>> STT3_PglB_C  STT3/PglB C-terminal beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.3     0.011        50      11      58 ..      74     120 ..      68     130 .. 0.82
   2 ?    7.9   4.4   0.00074       3.3      11      51 ..     166     209 ..     150     219 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.011
                  ----EEETTTEEEETTTTEEEETTEEEEEEEEEEEEETTTTEEEE..E CS
  STT3_PglB_C  11 knegveLgnGivlskdfkslkiggqkvpvktfveteydkngklkvket 58 
                  +++ +e++n i+ s++ + +++g+    vk++  t y +n ++k++++
   EFC35712.1  74 EKGNLEIANSIEDSSNHSIFSLGECIEHVKSI-TTTYAQNFNVKINVQ 120
                  5778999***************9999999886.577899988888776 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00074
                  ----EEETTTEEEETTTTEEEETTEEEEEE...EEEEEEETTTT CS
  STT3_PglB_C  11 knegveLgnGivlskdfkslkiggqkvpvk...tfveteydkng 51 
                  + ++++L+n+i l+++ ++l+ ++ +++++   ++v  + + ng
   EFC35712.1 166 DLNEINLNNNINLNENNNNLNNNNLNLNINdkkQLVTFKIIDNG 209
                  5579************************9722245555556665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (252 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1145  (0.063863); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.53
# Mc/sec: 1418.91
//
Query:       EFC35713.1  [L=119]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       447  (0.0249317); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 705.71
//
Query:       EFC35714.1  [L=367]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (367 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       947  (0.0528195); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2306.95
//
Query:       EFC35715.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      1e-34  118.0   5.9    3.8e-16   58.5   0.0    4.6  5  DUF4116        Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.023   13.9   3.4         10    5.4   0.0    4.2  4  DUF3666        Ribose-5-phosphate isomerase
       0.05   13.1   0.1        6.5    6.3   0.0    3.4  4  DNA_gyraseA_C  DNA gyrase C-terminal domain, beta-propeller
      0.053   12.2   0.0      0.077   11.7   0.0    1.2  1  Lgl_C          Lethal giant larvae(Lgl) like, C-terminal


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.3   5.7e-06     0.026      14      47 ..       9      42 ..       3      44 .. 0.88
   2 !   35.6   0.8   1.2e-12   5.5e-09       1      48 [.      20      69 ..      20      70 .. 0.87
   3 ?   -0.5   0.1      0.23     1e+03      21      41 ..      94     114 ..      85     118 .. 0.70
   4 !   58.5   0.0   8.5e-20   3.8e-16       1      49 []     122     170 ..     122     170 .. 0.99
   5 !   21.8   0.0   2.5e-08   0.00011       2      27 ..     173     198 ..     172     201 .. 0.94

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 5.7e-06
     DUF4116 14 salkylseeLknDkeivlkA.vkqngtalsyasee 47
                s+++y+  ++k D +iv+kA  k+n t+l y+  +
  EFC35715.1  9 SSFQYIG-KFKEDEDIVKKAlFKSNFTILHYINSD 42
                6899999.9**********9889999***999766 PP

  == domain 2  score: 35.6 bits;  conditional E-value: 1.2e-12
     DUF4116  1 DrEivleavkkngs.alkyl.seeLknDkeivlkAvkqngtalsyaseeL 48
                D++iv++a+ k ++ +l+y+ s+ L n++e+vl ++k+ng++++ ++e +
  EFC35715.1 20 DEDIVKKALFKSNFtILHYInSDFLLNNRELVLTILKSNGKCINEMPEAI 69
                9*******6665555*****66779**********************965 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.23
     DUF4116  21 eeLknDkeivlkAvkqngtal 41 
                 + + +D+e  + +++ n++ l
  EFC35715.1  94 KIIESDREDFKSILQFNPDLL 114
                 555677777777777777665 PP

  == domain 4  score: 58.5 bits;  conditional E-value: 8.5e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+ +ea++++g++l+++see+k Dke+vl Av +ng+al yas++L+
  EFC35715.1 122 DRELLKEALSHCGFCLRFASEEFKADKELVLTAVTKNGSALMYASPKLK 170
                 9*********************************************997 PP

  == domain 5  score: 21.8 bits;  conditional E-value: 2.5e-08
     DUF4116   2 rEivleavkkngsalkylseeLknDk 27 
                 +Eivl av+++g+a++++s++L+n k
  EFC35715.1 173 EEIVLAAVTNDGKAIRFASKRLSNQK 198
                 8**********************976 PP

>> DUF3666  Ribose-5-phosphate isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1     0.018        79      14      34 ..      20      40 ..      18      43 .. 0.84
   2 ?   -0.7   0.0      0.18   8.2e+02      28      37 ..      73      82 ..      68      92 .. 0.74
   3 ?    5.4   0.0    0.0023        10      14      24 ..     122     132 ..     111     139 .. 0.85
   4 ?    3.1   0.0     0.012        53      14      23 ..     147     156 ..     145     159 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.018
                -HHHHHHHT-STTHHHHHTTT CS
     DUF3666 14 DqdLvkgAisGerFqeyFFan 34
                D+d+vk A+    F  + + n
  EFC35715.1 20 DEDIVKKALFKSNFTILHYIN 40
                99*******999998777665 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.18
                HHHHTTT--- CS
     DUF3666 28 qeyFFancqd 37
                 e+FF  ++ 
  EFC35715.1 73 RECFFLAART 82
                59***88776 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0023
                 -HHHHHHHT-S CS
     DUF3666  14 DqdLvkgAisG 24 
                 D++L+k+A+s 
  EFC35715.1 122 DRELLKEALSH 132
                 9*******985 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.012
                 -HHHHHHHT- CS
     DUF3666  14 DqdLvkgAis 23 
                 D++Lv +A++
  EFC35715.1 147 DKELVLTAVT 156
                 9*******97 PP

>> DNA_gyraseA_C  DNA gyrase C-terminal domain, beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.32   1.4e+03      34      42 ..      16      24 ..      12      25 .. 0.82
   2 ?    1.8   0.0     0.037   1.7e+02       6      21 ..     130     145 ..     129     146 .. 0.88
   3 ?    1.5   0.0     0.046   2.1e+02      30      48 .]     160     182 ..     154     182 .. 0.76
   4 ?    6.3   0.0    0.0015       6.5       5      24 ..     179     198 ..     176     199 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.32
                   ETTTTSSEE CS
  DNA_gyraseA_C 34 klkegdklv 42
                   k+ke++ +v
     EFC35715.1 16 KFKEDEDIV 24
                   89***9998 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.037
                    EETTSEEEEEEGGGS- CS
  DNA_gyraseA_C   6 iTsnGyvkrfplselp 21 
                     ++ G+++rf  +e++
     EFC35715.1 130 LSHCGFCLRFASEEFK 145
                    6999*******99996 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.046
                    EEGS....ETTTTSSEEEEEEES CS
  DNA_gyraseA_C  30 vkgi....klkegdklvsvlvvs 48 
                      ++    klk+ +++v ++v++
     EFC35715.1 160 SALMyaspKLKDCEEIVLAAVTN 182
                    55566777999999999988875 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0015
                    EEETTSEEEEEEGGGS-BT- CS
  DNA_gyraseA_C   5 liTsnGyvkrfplselpeqg 24 
                     +T+ G+++rf    l++q+
     EFC35715.1 179 AVTNDGKAIRFASKRLSNQK 198
                    79*********988888775 PP

>> Lgl_C  Lethal giant larvae(Lgl) like, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   1.7e-05     0.077     265     301 ..     143     178 ..     116     200 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.7e-05
                 EEE-EEEEEEEEEEETTSEEEEEETTT--EEEEEE-S CS
       Lgl_C 265 kteekkkgivlvaltkdgevkvlslPsLkeikkvklp 301
                 +++  +k  vl a+tk+g++ +++ P+Lk+ +++ l 
  EFC35715.1 143 EFK-ADKELVLTAVTKNGSALMYASPKLKDCEEIVLA 178
                 333.68999**********************999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       710  (0.0396006); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1262.10
//
Query:       EFC35716.1  [L=257]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   3.8e-100  335.4   0.1      2e-99  333.0   0.1    1.8  1  Actin            Actin
  ------ inclusion threshold ------
       0.17   10.4   0.0       0.37    9.3   0.0    1.5  2  Methyltransf_29  Putative S-adenosyl-L-methionine-dependent m


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  333.0   0.1  2.2e-103     2e-99     113     407 .]       1     257 []       1     257 [] 0.98

  Alignments for each domain:
  == domain 1  score: 333.0 bits;  conditional E-value: 2.2e-103
       Actin 113 alEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtprylikkkkvveaess 211
                 +++i+fE+f vpa+y+a +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G++Lt++l+++l ++                     
  EFC35716.1   1 MTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMER--------------------- 78 
                 689**************************************************************************8..................... PP

       Actin 212 aekeelekltesyktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleeekskllgisel 308
                          ++s++t++e+e++++iKe++c+++ d+e+  + +++sss eksYeLPDg++i++g+eRf++pE+LF+p+ ig+e a         g++e 
  EFC35716.1  79 ---------GYSFNTTAEREIVRDIKEKLCYIALDFEAemKVAAESSSVEKSYELPDGNVITVGNERFRCPEVLFQPNFIGMEAA---------GVHET 159
                 .........9**************************996666677799***********************************99.........***** PP

       Actin 309 ivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGssvverkck 407
                 ++++i +cd+d+r++L+ n+v++GG+++++g+ eR+ kel+++a++++k+k++ap+ erkys+WiGGSiLAsl+tfqq+w++k+EYe+ G+ +v+rkc+
  EFC35716.1 160 TFNSIGKCDIDIRKDLYGNVVLSGGTTMFEGIAERMTKELTAMAPASMKIKVVAPP-ERKYSVWIGGSILASLSTFQQMWITKEEYEDAGPGIVHRKCF 257
                 ********************************************************.*****************************************6 PP

>> Methyltransf_29  Putative S-adenosyl-L-methionine-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.0   4.2e-05      0.37     104     163 ..      17      80 ..       4     101 .. 0.88
   2 ?   -2.6   0.0      0.17   1.5e+03      87     112 ..     181     206 ..     177     212 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 4.2e-05
  Methyltransf_29 104 klaelipliaaggkvrtvlDvGCgvas....fgayllsrdvltlslapkDeheaqvqfaLeRgv 163
                       ++ +++l a+g ++ +vlD G gv+     + +y l + +l l la +D  +  +++ +eRg 
       EFC35716.1  17 AIQAVLSLYASGRTTGIVLDSGDGVSHtvpiYEGYALPHAILRLDLAGRDLTDYLMKILMERGY 80 
                      68999999999************9985444489*****************************95 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.17
  Methyltransf_29  87 fPgggtqfkkgadkYidklaelipli 112
                        gg t+f+  a++  ++l+ + p+ 
       EFC35716.1 181 LSGGTTMFEGIAERMTKELTAMAPAS 206
                      679999**999999999999998874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       453  (0.0252663); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1567.02
//
Query:       EFC35717.1  [L=1402]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.2e-07   29.2   0.0    0.00082   19.6   0.0    2.7  2  Ank_5     Ankyrin repeats (many copies)
      9e-06   26.1   0.0    3.3e-05   24.4   0.0    2.0  1  Ank_4     Ankyrin repeats (many copies)
     0.0008   19.9   0.0     0.0038   17.8   0.0    2.2  2  Ank_2     Ankyrin repeats (3 copies)
     0.0013   19.0   0.1      0.019   15.4   0.0    2.7  2  Ank_3     Ankyrin repeat
     0.0055   17.1   0.0       0.02   15.4   0.0    1.9  2  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0     0.003        11      22      45 ..     178     201 ..     178     207 .. 0.87
   2 !   19.6   0.0   2.3e-07   0.00082       9      44 ..     228     264 ..     226     266 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.003
       Ank_5  22 vAakygaadvvrlLlargadlnlt 45 
                 +A++ g++d+v+++l++++d++  
  EFC35717.1 178 LAIWIGNLDLVKWCLEYRSDNGNN 201
                 59999***************9865 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 2.3e-07
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLl.argadlnl 44 
                 +  +dg g ++Lh+A+++ + ++v+lL+ ++ a++++
  EFC35717.1 228 CYKRDGAGLNILHYAIRGKNVEIVKLLIeKYKANPFQ 264
                 66789***********************999998875 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.0   9.1e-09   3.3e-05      12      55 .]     183     255 ..     177     255 .. 0.96

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 9.1e-09
       Ank_4  12 grlelvrlLlekgad..............................inaqdnrsGetalhiAakrgnveilklLl 55 
                 g+l+lv+++le++ d                              ++++ ++ G++ lh+A+++ nvei+klL+
  EFC35717.1 183 GNLDLVKWCLEYRSDngnnridtllrtgilegepssynivssygaCYKR-DGAGLNILHYAIRGKNVEIVKLLI 255
                 89********999999999999***************************.***********************8 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   1.1e-06    0.0038       7      78 ..     182     261 ..     148     267 .. 0.58
   2 ?   -3.8   0.0         5   1.8e+04      25      34 ..     920     929 ..     901     955 .. 0.52

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.1e-06
       Ank_2   7 ngnlelvklLl.egadpn.kngktaLhyAakngnleivklLleh.....adndgrtpLhyAarsghleivklLlek.gad 78 
                  gnl+lvk+ l + +d + +   t L + + +g      +  ++      d  g ++LhyA+r ++ eivklL+ek +a+
  EFC35717.1 182 IGNLDLVKWCLeYRSDNGnNRIDTLLRTGILEGEPSSYNIVSSYgacykRDGAGLNILHYAIRGKNVEIVKLLIEKyKAN 261
                 45556666666533332211223444444444422222222222322233344777777777777777777777653444 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 5
       Ank_2  25 ngktaLhyAa 34 
                 ++ +aL++A 
  EFC35717.1 920 EEYSALIIAR 929
                 4455555442 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.66   2.4e+03      13      27 ..     183     196 ..     178     200 .. 0.82
   2 !   15.4   0.0   5.4e-06     0.019       2      29 ..     235     262 ..     234     263 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.66
       Ank_3  13 gnleivkfLlenkga 27 
                 gnl++vk++le +  
  EFC35717.1 183 GNLDLVKWCLE-YRS 196
                 8999*******.655 PP

  == domain 2  score: 15.4 bits;  conditional E-value: 5.4e-06
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                 G ++Lh+A+r  n+eivk+L+e++ a++
  EFC35717.1 235 GLNILHYAIRGKNVEIVKLLIEKYKANP 262
                 7899******************998875 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0         5   1.8e+04       8      22 ..     178     192 ..     178     197 .. 0.80
   2 !   15.4   0.0   5.5e-06      0.02       5      27 ..     238     262 ..     235     266 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 5
                 HHHHHTTHHHHHHHH CS
         Ank   8 lAatngkkriiklLL 22 
                 lA+++g+++ +k+ L
  EFC35717.1 178 LAIWIGNLDLVKWCL 192
                 79999*999999755 PP

  == domain 2  score: 15.4 bits;  conditional E-value: 5.5e-06
                 HHHHHHHHTTHHHHHHHH..TTTST CS
         Ank   5 PLHlAatngkkriiklLL..hGAnl 27 
                  LH+A+++++++i+klL+  + An+
  EFC35717.1 238 ILHYAIRGKNVEIVKLLIekYKANP 262
                 59*****999********8336998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       832  (0.0464053); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.89u 0.30s 00:00:01.19 Elapsed: 00:00:00.50
# Mc/sec: 8382.07
//
Query:       EFC35718.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1586.03
//
Query:       EFC35719.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.029   14.4   0.2      0.029   14.4   0.2    1.7  2  Cdc6_C       CDC6, C terminal winged helix domain
       0.67    9.9   3.6        1.3    9.1   0.1    2.4  2  Nudix_N_2    Nudix N-terminal
        1.8    8.1   4.6       0.29   10.6   0.4    1.9  2  zf-ribbon_3  zinc-ribbon domain


Domain annotation for each model (and alignments):
>> Cdc6_C  CDC6, C terminal winged helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.2   4.8e-06     0.029      18      59 ..      20      64 ..      10      69 .. 0.87
   2 ?   -2.7   0.1         1   6.1e+03       9      20 ..      82      93 ..      76      98 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 4.8e-06
                HHHHHHHHHHHHHHTT-...----HHHHHHHHHHHHHTTSEEEEE CS
      Cdc6_C 18 tgevyevYkslCesegv...dpltqrevsdllseLemlgilelek 59
                + ++++ Y+++C+++++   d l+  + +++++ L+   i ++ +
  EFC35719.1 20 LEKIHKNYERICDRYNLekkDFLNDVSLYNHCDLLSVSNIYSTIR 64
                679**************77778999**********9999887765 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1
                CHCSSS-EEHHH CS
      Cdc6_C  9 rksgkeevttge 20
                rk++++++t+ge
  EFC35719.1 82 RKRNQNTTTLGE 93
                356777777776 PP

>> Nudix_N_2  Nudix N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   1.1     0.097   5.8e+02       3       7 ..     111     115 ..     109     117 .. 0.61
   2 ?    9.1   0.1   0.00021       1.3      14      32 ..     150     168 ..     143     168 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.097
                 -TTT- CS
   Nudix_N_2   3 CsqCG 7  
                 C +CG
  EFC35719.1 111 CAHCG 115
                 66666 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00021
                 --TT-SS-EEEETTTTEEE CS
   Nudix_N_2  14 ipdgDnreRlvCpaCgtih 32 
                 + dgD    +vC  Cg++h
  EFC35719.1 150 LTDGDGVSLHVCVGCGMVH 168
                 568888888*********9 PP

>> zf-ribbon_3  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.4   4.9e-05      0.29      13      24 ..     105     116 ..     101     117 .. 0.86
   2 ?   -2.6   0.3       0.7   4.2e+03      19      24 ..     161     166 ..     160     167 .. 0.52

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 4.9e-05
  zf-ribbon_3  13 ssddnvCpyCGt 24 
                  +s+d++C++CG+
   EFC35719.1 105 TSSDKTCAHCGG 116
                  799********6 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.7
  zf-ribbon_3  19 CpyCGt 24 
                  C  CG+
   EFC35719.1 161 CVGCGM 166
                  444665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1457  (0.081265); expected 358.6 (0.02)
Passed bias filter:                      665  (0.0370907); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1343.17
//
Query:       EFC35720.1  [L=266]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-08   34.3   0.0    6.9e-08   32.7   0.0    1.8  2  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   0.0   3.9e-12   6.9e-08       3      93 ..       6      98 ..       4     105 .. 0.83
   2 ?   -2.0   0.0      0.24   4.3e+03      62      74 ..     177     189 ..     154     199 .. 0.62

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 3.9e-12
                EEEEEEEEESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEE.EEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHT CS
          C2  3 levtvieAknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWn.ekftfevaeleeakLeveVfdndrlskddfiGkveiplstlls 93
                l +t +++++Lp+ d  +s+d+y++v +     +++++kT+ +++  nP W+   f  +v+   ++   ve++d+d+  +++ + ++ ++l +l+s
  EFC35720.1  6 LNLTLHCGRDLPKADLLSSIDAYAVVIVpiigGQTKTFKTKCVQDDPNPDWEfDLFCTDVD--GTRDCLVEIWDEDT-LRNEKVCTAILSLVELKS 98
                8899**********************999**999*******999999****6333444555..588888********.666668888888877655 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.24
                 TSEEEEEEEEECS CS
          C2  62 eakLeveVfdndr 74 
                  ++ +++V+d + 
  EFC35720.1 177 GKRFKISVLDTSE 189
                 4555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       529  (0.0295053); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.36u 0.25s 00:00:00.61 Elapsed: 00:00:00.37
# Mc/sec: 2127.09
//
Query:       EFC35721.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-35  123.2   0.9    1.6e-35  122.8   0.9    1.1  1  Pkinase         Protein kinase domain
    3.7e-14   52.6   0.4      5e-14   52.2   0.4    1.1  1  Pkinase_Tyr     Protein tyrosine kinase
    8.7e-07   28.2   1.3    1.4e-06   27.5   1.3    1.2  1  Haspin_kinase   Haspin like kinase domain
    5.2e-06   25.5   0.1    7.9e-06   24.9   0.1    1.2  1  Pkinase_fungal  Fungal protein kinase
     0.0011   18.6   2.5     0.0026   17.4   1.9    1.6  1  Choline_kinase  Choline/ethanolamine kinase
     0.0024   17.3   0.6     0.0042   16.4   0.6    1.4  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
      0.005   16.8   0.1      0.007   16.3   0.1    1.2  1  APH             Phosphotransferase enzyme family
     0.0065   15.8   0.0      0.025   13.9   0.0    1.8  2  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  122.8   0.9   6.9e-39   1.6e-35       5     245 ..      13     273 ..      10     304 .. 0.81

  Alignments for each domain:
  == domain 1  score: 122.8 bits;  conditional E-value: 6.9e-39
                 EEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE....SSEEEEEEE--TTEBHHHHHH........H CS
     Pkinase   5 eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee....kdelylvleyveggeladlle........r 91 
                 +k+G+G+ G V+k+++++ ++iv++K+  + +++ ++++k     +++k+ + + ivr +e+       +++ yl++e+ +    +++++         
  EFC35721.1  13 SKIGKGAQGIVFKCFHTQLEQIVVLKVNITPEEQPERTEK---LFNFMKTPNLKGIVRTFECNFYelhnSKYSYLIMEMGSPL--DHVMSemhqnysnL 106
                 79*************************9999998877654...467999999******9987432355599999****98744..44443332222232 PP

                 HSS--HH.......HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH........TTSCBS CS
     Pkinase  92 kgslsee.......eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl........keneys 175
                     +++       e+ ++++++leg+  lH+ ++ HrDlK +N++i+++g+ K++DF+ +k ++s+++ t  +gt eYlAPEv         ++ ++s
  EFC35721.1 107 ----EHClstqdliEVLQYFTEVLEGVISLHNLNFTHRDLKLANVIINNEGHAKLIDFDNSKVIQSNHSITVNIGTWEYLAPEVYdeeegkqtENFKIS 201
                 ....33355556778889*******************************************************************99887743334569 PP

                 HHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHT..HHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT CS
     Pkinase 176 kkvDvWslGvilyelltgkppfsgekgkekvekeldq..lekilkilgetkeklpeaseiseeakdllkkll 245
                 k++D +s+G++l+++++++++   ++++++ ++ l       ++k+l + + +   +++i +e+ ++++  l
  EFC35721.1 202 KNCDTYSMGCVLMKMICNRTLSIISTNEDSGSSCLFGvgKNYFFKLLSTPQGEAMLHQSIRKEIDKFIDPNL 273
                 *******************99886666666666555544466788888888888888888888888887555 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.2   0.4   2.2e-17     5e-14       5     200 ..      13     218 ..       9     231 .. 0.80

  Alignments for each domain:
  == domain 1  score: 52.2 bits;  conditional E-value: 2.2e-17
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE....SSSSEEEEEE--T.TEBHHHHHHHT.. CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct....keepllivteyvk.gGdLlkfLrkk.. 95 
                  +k+G+Ga G V+++  +    + e+ V++K+    + ee+ e+  +  ++mk+ + + iv+   +      +++  ++++e+ +   ++ + ++++  
   EFC35721.1  13 SKIGKGAQGIVFKCFHT----QLEQIVVLKVN--ITPEEQPERTEKLFNFMKTPNLKGIVRTFECNFyelhNSKYSYLIMEMGSpLDHVMSEMHQNys 104
                  68************999....77778888887..33444455666667899999*******999887777677779*****85314455555555588 PP

                  ....CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE........ CS
  Pkinase_Tyr  96 ....ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk........ 181
                        ++ +l ++l++ ++v +G+  L++ ++ Hrdl   Nv+++++ ++k+ Df  ++ i++    ++ + +    +++apE+ +e++        
   EFC35721.1 105 nlehCLSTQDLIEVLQYFTEVLEGVISLHNLNFTHRDLKLANVIINNEGHAKLIDFDNSKVIQS---NHSITVNIGTWEYLAPEVYDEEEgkqtenfk 199
                  7544444445556678899*******************************************44...44455567789********999999999999 PP

                  EEHHHHHHHHHHHHHHHHT CS
  Pkinase_Tyr 182 ftsksDvWsfGvllwEift 200
                  ++++ D +s G +l+ +++
   EFC35721.1 200 ISKNCDTYSMGCVLMKMIC 218
                  99***********998876 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   1.3   6.2e-10   1.4e-06     115     263 ..      22     172 ..       4     176 .. 0.71

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 6.2e-10
  Haspin_kinase 115 evyqtke.kdkevvlKvipl..evledvtis..kelslkelks.lklvkgtypglllllqdkvlkekpdfyseqqlflvlllkdkGtdLeev.klk 203
                     v+++ + + +++v+ ++ +  e +++ t +  ++++  +lk  ++ ++  + +l     +++++e      +    ++ +++++ ++Le++ + +
     EFC35721.1  22 IVFKCFHtQLEQIVVLKVNItpEEQPERTEKlfNFMKTPNLKGiVRTFECNFYELHNSKYSYLIMEM----GSPLDHVMSEMHQNYSNLEHClSTQ 113
                    5666655433455555555544444444443344455566664256677777777777777777777....55556678899999999**999999 PP

  Haspin_kinase 204 swkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRlessegkv 263
                    +  ++l+ f ++++ +     +++F HRdL+l n++++++++  lid+  s++ +s++ +
     EFC35721.1 114 DLIEVLQYFTEVLEGVISL-HNLNFTHRDLKLANVIINNEGHAKLIDFDNSKVIQSNHSI 172
                    9999999999999876544.68*****************************998666655 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.1   3.5e-09   7.9e-06     303     387 ..     113     188 ..     105     197 .. 0.87

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 3.5e-09
  Pkinase_fungal 303 espkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlk 387
                     ++  e+l+ + ++++g  sL+ + ++ HrD    N++i+     +e +  LiD+D  k ++   ++s     +GT e++a ev  
      EFC35721.1 113 QDLIEVLQYFTEVLEGVISLH-NLNFTHRDLKLANVIIN-----NEGHAKLIDFDNSKVIQS--NHSI-TVNIGTWEYLAPEVYD 188
                     566789999************.*****************.....778899**********95..4543.579********99876 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   1.9   1.2e-06    0.0026     112     176 ..     100     165 ..      92     181 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.2e-06
                     CHHGGCCHCCCTHHHHHHHHHTHHHHHHCHGG-..EEEE-S--SGGGEEE.-CTTEEEE--GTT-EE CS
  Choline_kinase 112 kekkkkqlklinledlekelekleklleelesp..vvfcHnDlqegNillnkeekklvlIDFEYagy 176
                     ++++++  ++++++dl + l+ + ++le   s   ++f H Dl   N++  ++e++  lIDF  + +
      EFC35721.1 100 HQNYSNLEHCLSTQDLIEVLQYFTEVLEGVISLhnLNFTHRDLKLANVII-NNEGHAKLIDFDNSKV 165
                     56677778899999999999999999975544345***************.9999*******98865 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.6   1.9e-06    0.0042     126     172 ..     124     166 ..      94     175 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.9e-06
         Kdo 126 avgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldkarlr 172
                 +v   +  lh+++  H+dl   n+ +++e+    ++ liD+d ++  
  EFC35721.1 124 EVLEGVISLHNLNFTHRDLKLANVIINNEG----HAKLIDFDNSKVI 166
                 55566778**********************....********99765 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   3.1e-06     0.007     152     197 ..     118     164 ..      88     167 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.1e-06
                 HHHHHHHH--S...SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 152 vlaalaallpg...elptvllHgDlhpgNllvdpddgrvtGviDfedag 197
                 vl+ + + l g        ++H+Dl++ N++++ +++    +iDf+ ++
  EFC35721.1 118 VLQYFTEVLEGvisLHNLNFTHRDLKLANVIINNEGHAK--LIDFDNSK 164
                 44444444444444677789*************444444..9***9876 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.43   9.5e+02      18      54 ..      13      49 ..       5      55 .. 0.82
   2 !   13.9   0.0   1.1e-05     0.025     152     246 ..     124     219 ..      75     244 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.43
  Kinase-like 18 ellkkgdrsvvfevkdqetgeplavkvfllpseaskk 54
                 + ++kg +++vf+    +  + +++kv ++p+e +++
   EFC35721.1 13 SKIGKGAQGIVFKCFHTQLEQIVVLKVNITPEEQPER 49
                 6789999999**99999989999999*9999976654 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 1.1e-05
  Kinase-like 152 qlirlaanLqakglvhgkftvdnllldekgglmlggft..aLvragtkvvlsevekgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwcl 246
                  +++  + +L+++   h +++  n++ +++g  +l +f+  + ++  ++  ++     +  pE+  +  g ++ ++ k++ + d++ +G v   + c 
   EFC35721.1 124 EVLEGVISLHNLNFTHRDLKLANVIINNEGHAKLIDFDnsKVIQSNHSITVNIGTWEYLAPEVYDEEEG-KQTENFKISKNCDTYSMGCVLMKMICN 219
                  46666789****************************962257777788887888889999******999.8889*********************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 2153.19
//
Query:       EFC35722.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       539  (0.030063); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.45
# Mc/sec: 1577.76
//
Query:       EFC35723.1  [L=622]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.8e-28   98.0   0.5    9.9e-28   97.2   0.5    1.3  1  Pkinase         Protein kinase domain
    1.5e-17   63.8   0.3    2.6e-17   63.0   0.3    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
    1.1e-09   37.8   0.1    1.8e-09   37.1   0.1    1.3  1  Gln-synt_C      Glutamine synthetase, catalytic domain
    4.9e-05   22.3   0.0    9.6e-05   21.3   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
        0.6   10.3   2.9        2.2    8.5   0.1    3.1  3  DUF2615         Protein of unknown function (DUF2615)
        1.5    8.7   8.1       0.41   10.6   0.5    2.3  2  Wzy_C_2         Virulence factor membrane-bound polymerase, C
        5.1    7.1  15.7          3    7.8   3.4    2.8  2  DUF3043         Protein of unknown function (DUF3043)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.2   0.5   3.9e-31   9.9e-28       3     167 ..     394     558 ..     392     560 .. 0.91

  Alignments for each domain:
  == domain 1  score: 97.2 bits;  conditional E-value: 3.9e-31
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEE.EEEE--TTEBHHHHHHHHSS--HHHH CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely.lvleyveggeladllerkgslseeea 100
                  +e + +G+fG+Vyk++ +++ ++ A+K  k+ ++   +    +rE + ++++ h ni++  + f   d ++ + +e+++  +l++++++++ +se+ +
  EFC35723.1 394 SKEFIATGGFGTVYKVT-TKNYEKLALKLGKQTSEVMIS----VREYQKMRQITHCNIIKTCDLFMIGDGIVgIEMELMKM-SLKNVMTTEKPFSEKIM 486
                 5678889**********.689999****99999888755....7***********************99998899****95.5**************** PP

                 HHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET.TTE......EEE-SGTTSEESSSSCSBCTTTSCGGGS-HH CS
     Pkinase 101 kkiakqilegleylHskgiiHrDlKpeNiLide.kge......lKitDFGlakelessskltsfvgtseYlAPE 167
                 + i+ q++++le l   ++iHrD+Kp+NiLi + +        + ++DFGla++l++ +  t + gt +++APE
  EFC35723.1 487 QTILVQMCSALEILKVCNLIHRDIKPDNILIRDlD-LereevsVVLSDFGLARNLDTFT-STGISGTVNFIAPE 558
                 *******************************9532.1355678**************88.999**********9 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.0   0.3     1e-20   2.6e-17       5     175 ..     396     558 ..     393     561 .. 0.88

  Alignments for each domain:
  == domain 1  score: 63.0 bits;  conditional E-value: 1e-20
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE.SSSSEEEEEE--TTEBHHHHHHHTCTTTSB CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct.keepllivteyvkgGdLlkfLrkkekeklt 101
                  + ++ G fG+V++ t k     + +k a+K  k++++       ++e++ m+++ h ni+k   + +  ++ + i +e++k  +L++ ++++  ++++
   EFC35723.1 396 EFIATGGFGTVYKVTTK-----NYEKLALKLGKQTSE---VMISVREYQKMRQITHCNIIKTCDLFMiGDGIVGIEMELMKM-SLKNVMTTE--KPFS 482
                  56899**********99.....8999****9966544...457799*******************99566667788999987.8******98..99** PP

                  HHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE......TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HH CS
  Pkinase_Tyr 102 lkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse......nkvvkisDfGLardiekddeyvkkeeaklpvkWmapE 175
                   k +  + +q+++++e L+  +l+Hrd+   N+L+++      +  v +sDfGLar++    ++ ++++    v+++apE
   EFC35723.1 483 EKIMQTILVQMCSALEILKVCNLIHRDIKPDNILIRDldlereEVSVVLSDFGLARNL----DTFTSTGISGTVNFIAPE 558
                  ************************************888887677999**********....666777888899999998 PP

>> Gln-synt_C  Glutamine synthetase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   0.1     7e-13   1.8e-09     284     345 .]     557     618 ..     541     618 .. 0.90

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 7e-13
                 TTTHTSS-B--SSHHHHHHHHHCSHHHCCSS-HHHHHHHHHHHHHCHHHH.HCT--HHHHHHH CS
  Gln-synt_C 284 peerkgieelPasleeAlealeedellkevlgeevieaylalkraEleel.eeevsdwelery 345
                 pe ++g+e lP++l eA++++e+d l+kev+ e+ ++ +  +kraE++++ ++ v+dwe+ery
  EFC35723.1 557 PE-KEGLELLPENLLEAIKEFEKDPLMKEVFLEHNFNMFKMAKRAEWDKYvHHCVTDWEFERY 618
                 43.478999***************************************9956779******98 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.0   3.8e-08   9.6e-05     314     382 ..     492     556 ..     472     561 .. 0.81

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 3.8e-08
  Pkinase_fungal 314 DaIkghrsLflkagiLHrDiSenNilitds.kkegerkglLiDLDlakelsddssesgarertGTleFma 382
                     +   +++ L   ++++HrDi  +Nili d   + +e + +L+D+ la +l++ +s        GT++F+a
      EFC35723.1 492 QMCSALEILK-VCNLIHRDIKPDNILIRDLdLEREEVSVVLSDFGLARNLDTFTS----TGISGTVNFIA 556
                     5556777787.9*****************94455888999***********6433....34789999998 PP

>> DUF2615  Protein of unknown function (DUF2615)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.1   0.00085       2.2      50      83 ..      46      79 ..      32      83 .. 0.81
   2 ?   -1.8   0.3       1.4   3.5e+03      58      73 ..     216     231 ..     200     238 .. 0.57
   3 ?   -0.5   0.0      0.53   1.4e+03      59      91 ..     341     373 ..     335     387 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00085
     DUF2615 50 keggsslfliallwlvvaavlfllrPsslrnasa 83
                +++ s lf+++++ l++++++f++r ++++  ++
  EFC35723.1 46 DQSISFLFILLFISLILVMIIFIVRNQTWKTLRK 79
                55667788999999*************9987644 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.4
     DUF2615  58 liallwlvvaavlfll 73 
                 +  ++ +++++++f++
  EFC35723.1 216 ISSAMYFLLVVAVFVM 231
                 3333333344444443 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.53
     DUF2615  59 iallwlvvaavlfllrPsslrnasaknkpsrkd 91 
                  +l++ ++++ l+      + ++++++  +  +
  EFC35723.1 341 GILIFSILVMCLYHPSFDFFNRNQSEQDTTTTN 373
                 567788888888876655555442222222222 PP

>> Wzy_C_2  Virulence factor membrane-bound polymerase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.5   0.00016      0.41      25      79 ..      54     111 ..      50     139 .. 0.77
   2 ?    1.5   1.8     0.097   2.5e+02      23     103 ..     220     295 ..     219     299 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00016
     Wzy_C_2  25 fllaaflvlgllds...ksrsrrlrlrpklvlrvvalvlallglalllsilhdyqrle 79 
                 +ll++ l+l+++     ++ ++ lr++ + vl +v ++l++ +lal++ ++ ++  ++
  EFC35723.1  54 ILLFISLILVMIIFivrNQTWKTLRKAQRIVLILVNTLLIVQTLALCARTAYTFCNIS 111
                 555555555444434556***************************9999999987555 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.097
     Wzy_C_2  23 spfllaaflvlglldsksrsrrlrlrpklvlrvvalvlallglalllsilhdyqrleqlyltsepneaalrevtnpkvwkd 103
                 ++fll++++ ++l+ +     +l++    ++ ++ + +a++++ l++++     +++++++  ++ +++++++++   wk+
  EFC35723.1 220 MYFLLVVAVFVMLVIE-----SLKVTVDILFIFSIACFAFFAIQLIVQTIAISIVFSRVIILLNKTRKQFKDQSQSYSWKQ 295
                 6999999999988888.....566655555555555566666666666666666999999999999999999887777765 PP

>> DUF3043  Protein of unknown function (DUF3043)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   4.5      0.02        50      72     128 ..      45     102 ..      43     116 .. 0.76
   2 ?    7.8   3.4    0.0012         3      63     125 ..     201     266 ..     194     292 .. 0.66

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.02
     DUF3043  72 VDsrrnlgelflplalvvlvlllv.slvkvpevqavvsllllvllllvvidgillgrk 128
                 +D  +++  ++l++ l++++++++  ++++++++++  ++l+++  l++++++ l+ +
  EFC35723.1  45 IDQSISFLFILLFISLILVMIIFIvRNQTWKTLRKAQRIVLILVNTLLIVQTLALCAR 102
                 5666666666666666666664444889999999999999999999999988877765 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0012
     DUF3043  63 pvRryvRDlVDsrrnlgelflplalvvlvlllv..slvkvpevqavvsllllv.llllvvidgill 125
                 ++ + +R + D+ + +++ + +l++v ++++lv  sl  +  +  ++s+++++ + + +++++i +
  EFC35723.1 201 KQTKIIRKIFDTSFFISSAMYFLLVVAVFVMLVieSLKVTVDILFIFSIACFAfFAIQLIVQTIAI 266
                 667899**********99888887777777555234444444444555555543333344444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (622 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1810  (0.100954); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.88u 0.38s 00:00:01.26 Elapsed: 00:00:00.58
# Mc/sec: 3247.24
//
Query:       EFC35724.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2044  (0.114005); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.35s 00:00:00.96 Elapsed: 00:00:00.56
# Mc/sec: 1026.92
//
Query:       EFC35725.1  [L=103]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
          1    7.5  12.8       0.97    7.5  12.8    1.0  1  SSP160    Special lobe-specific silk protein SSP160
        8.9    6.5   6.9        8.2    6.6   0.1    2.1  2  PBP3      Penicillin Binding Protein 3 Domain


Domain annotation for each model (and alignments):
>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5  12.8   0.00011      0.97     284     337 ..       9      62 ..       1      85 [. 0.67

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00011
      SSP160 284 nstssststststttststtttnsttstnstsssnsstiagsidiaanltvalq 337
                    s+ ++t+t+ttt t t t n       + ss s      id ++n+t+ ++
  EFC35725.1   9 TYNSNNNTTTTTTTTNTNTCTNNNNHGIRRSDSSSSNNNMSFIDETSNVTMKVK 62 
                 334555566666666666666666666666666666667778898888887654 PP

>> PBP3  Penicillin Binding Protein 3 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   3.8     0.033     3e+02      70     100 ..       4      35 ..       1      37 [. 0.50
   2 ?    6.6   0.1   0.00092       8.2      15      51 ..      37      74 ..      35      79 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.033
        PBP3  70 kvrrpl.atkaftaastlvssadtalsaddeG 100
                 +++r    ++ +t+++t++++ +t  + +++G
  EFC35725.1   4 NTNRDTyNSNNNTTTTTTTTNTNTCTNNNNHG 35 
                 34444404455555555555556655555556 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.00092
        PBP3 15 prpkeikeaaelpLid.vanrkisvevlpkgekievaa 51
                +r  +  +++++++id  +n++++v+v  +++++++++
  EFC35725.1 37 RRSDSSSSNNNMSFIDeTSNVTMKVKVKKRNHQLNIKQ 74
                6667777888999996489****************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2595  (0.144738); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.48
# Mc/sec: 646.61
//
Query:       EFC35726.1  [L=181]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       798  (0.0445089); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 1184.71
//
Query:       EFC35727.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-15   56.2   0.1    5.1e-15   55.9   0.1    1.0  1  Profilin  Profilin
  ------ inclusion threshold ------
        0.1   12.9   0.1       0.17   12.2   0.1    1.3  1  DUF1922   Domain of unknown function (DUF1922)


Domain annotation for each model (and alignments):
>> Profilin  Profilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.9   0.1   5.7e-19   5.1e-15       3     124 ..       6     128 ..       5     130 .. 0.85

  Alignments for each domain:
  == domain 1  score: 55.9 bits;  conditional E-value: 5.7e-19
                 HHHHHHCCCH...HCSSESEEEEEETTSSSEEEEETTGG--HHHHHHHHHHHHSTCHHHHH-EEETTEEEEEEEEETTEEEEE.ETTEEEEEEE-SSEE CS
    Profilin   3 Wqayvdesll...gtgkvdkAaIigadggsvwaasegfkvtpeevkaivkafkdpsklqsnGvtiggekYlviraddesiygk.kgkegvvivktkqal 97 
                 W a+v+  ll   ++   ++  ++gadg s+w   ++++v+++e++++++a+k +s+ ++  +t+gg+k++ +radd  +     +k+ v+    k++ 
  EFC35727.1   6 WTAWVQGALLaplAQSGASAVLLMGADG-SMWGLAGQWNVSAQEAATLANAIK-TSAGAPISCTLGGVKFMGMRADDSEFVSNsTQKTCVCGHMLKKTT 102
                 9999999988555455567777778888.************************.9999*******************9988875888677777777777 PP

                 EEEEE-TTS-HHHHHHHHHHHHHHHHH CS
    Profilin  98 viavydegvqpgnankavekladyLis 124
                 +++ +  + ++ n n+av k+a+ L++
  EFC35727.1 103 IVVWGALD-HARNINAAVSKVAEALAQ 128
                 77777776.***************986 PP

>> DUF1922  Domain of unknown function (DUF1922)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   1.9e-05      0.17      18      53 ..      87     122 ..      83     128 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.9e-05
                 -SEEEETTTEEEE--SSS-BS--SSHHHHHHHHHHH CS
     DUF1922  18 aktrkCvCGktikvkerrilkkaedaeeAselVrkl 53 
                 + +++CvCG+ +k  +  +    ++a++   +V k+
  EFC35727.1  87 STQKTCVCGHMLKKTTIVVWGALDHARNINAAVSKV 122
                 679*********999988888777777777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       478  (0.0266607); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.33s 00:00:00.81 Elapsed: 00:00:00.51
# Mc/sec: 802.72
//
Query:       EFC35728.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2486  (0.138658); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.77u 0.38s 00:00:01.14 Elapsed: 00:00:00.57
# Mc/sec: 1151.29
//
Query:       EFC35729.1  [L=300]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-09   37.4   1.4       0.97    9.7   0.1    5.5  5  LRR_6            Leucine Rich repeat
    1.4e-07   31.1   7.1    6.8e-06   25.7   1.2    3.0  4  LRR_8            Leucine rich repeat
    2.6e-05   24.0   0.0    4.4e-05   23.3   0.0    1.4  1  Methyltransf_16  Lysine methyltransferase
    5.8e-05   23.4   5.1       0.37   11.3   0.7    4.1  5  LRR_4            Leucine Rich repeats (2 copies)
      9e-05   22.4   0.1       0.57   10.0   0.0    2.8  3  DUF4347          Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
      0.026   15.0   1.9         34    5.5   0.0    4.4  5  LRR_1            Leucine Rich Repeat
      0.047   13.6   0.8        0.1   12.5   0.8    1.5  1  Cas6             Cas6 Crispr
      0.053   13.0   0.2       0.49    9.9   0.0    2.2  3  LRR_9            Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0      0.01        23       5      23 ..      52      70 ..      49      71 .. 0.89
   2 ?    2.8   0.0     0.067   1.5e+02       5      15 ..      76      86 ..      73      95 .. 0.83
   3 !    8.6   0.0   0.00095       2.1       5      19 ..     100     114 ..      97     119 .. 0.88
   4 ?    5.0   0.0     0.013        29       4      24 .]     123     143 ..     120     143 .. 0.90
   5 !    9.7   0.1   0.00043      0.97       5      20 ..     148     163 ..     145     165 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.01
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                L++L++ g +I +eG+  +
  EFC35729.1 52 LKSLHIYGSQIRGEGVRYI 70
                9**************9876 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.067
       LRR_6  5 LteLdLsgNdI 15
                Lt Ld+++++I
  EFC35729.1 76 LTNLDIRSHNI 86
                9********98 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00095
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt+L++ gN+Ig +G
  EFC35729.1 100 LTTLNIYGNHIGAKG 114
                 9************99 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.013
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt+L ++ N +g eGa+ L+
  EFC35729.1 123 QLTTLFIAENSVGVEGAKYLS 143
                 699**************9885 PP

  == domain 5  score: 9.7 bits;  conditional E-value: 0.00043
       LRR_6   5 LteLdLsgNdIgDeGa 20 
                 Lt L +s N +g+eG+
  EFC35729.1 148 LTNLGISVNWLGNEGL 163
                 9**************8 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.15   3.5e+02      43      56 ..      44      57 ..      15      62 .. 0.69
   2 !    7.5   0.5    0.0015       3.4      19      58 ..      44      83 ..      29      86 .. 0.86
   3 !   25.7   1.2     3e-09   6.8e-06       2      59 ..      75     132 ..      74     134 .. 0.96
   4 !   16.2   0.5   2.9e-06    0.0066       2      59 ..      99     156 ..      98     158 .. 0.96

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.15
                GGGTT--S-.EEE- CS
       LRR_8 43 gafsgLpsLrsLdL 56
                + +s L++L+sL++
  EFC35729.1 44 HHLSELKQLKSLHI 57
                34555555555554 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0015
                TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8 19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58
                +  + l++Lk+L++   +++    + +s L++L+ Ld+++
  EFC35729.1 44 HHLSELKQLKSLHIYGSQIRGEGVRYISELKQLTNLDIRS 83
                5667899**************999************9987 PP

  == domain 3  score: 25.7 bits;  conditional E-value: 3e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+Ld+++ ++ +++ +  + l++L++L++  N +     + +s L++L+ L +  N
  EFC35729.1  75 QLTNLDIRSHNIFHIGAKYLSELKQLTTLNIYGNHIGAKGSKYISELNQLTTLFIAEN 132
                 7*****************************************************9988 PP

  == domain 4  score: 16.2 bits;  conditional E-value: 2.9e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+L++  N++ + + +  + l++L++L + +N+  +  ++ +s L++L+ L +s N
  EFC35729.1  99 QLTTLNIYGNHIGAKGSKYISELNQLTTLFIAENSVGVEGAKYLSELKQLTNLGISVN 156
                 79***************************************************99977 PP

>> Methyltransf_16  Lysine methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.0   1.9e-08   4.4e-05      84     160 ..     163     242 ..     156     260 .. 0.81

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 1.9e-08
  Methyltransf_16  84 llkknielnknalkskvkvevLdWgeeleedll...ekeevDlilaaDcvYledslelLvkvLkellkkeskvlvaykkr 160
                      l  +n++ln +  ++ ++v+   Wge+le+ +    eke++D+il +D+++++   ++L+++ + l+++++ ++v y + 
       EFC35729.1 163 LAYRNVALNFDEDNTVMEVRGHAWGEKLEQTFGkgeEKETFDIILLSDLLFNHFCHSQLLDSCEYLSHPNTLIYVGYSHH 242
                      56689***9888888889999*******876542225778***********************************99876 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.031        69      18      36 ..      43      62 ..      23      65 .. 0.68
   2 !    9.2   0.1   0.00077       1.7       1      33 [.      50      85 ..      50      88 .. 0.83
   3 !   11.3   0.7   0.00017      0.37       1      36 [.      74     110 ..      74     122 .. 0.81
   4 !   10.7   0.1   0.00026      0.57       1      33 [.      98     132 ..      98     150 .. 0.80
   5 !    5.7   0.1    0.0096        21       2      31 ..     123     154 ..     122     161 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.031
                -..HHH-TT--EEE-.-S--- CS
       LRR_4 18 l..leklpnLkeLdLsgNnli 36
                   l+ l++Lk+L++ g  +i
  EFC35729.1 43 VhhLSELKQLKSLHIYGS-QI 62
                3445569******99765.54 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00077
                SS--EEE--SS---E-S-..HHH-TT--EEE-..-S CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdL.sgN 33
                ++L++L++ + q++  +   ++ l++L+ Ld+ s+N
  EFC35729.1 50 KQLKSLHIYGSQIRGEGVryISELKQLTNLDIrSHN 85
                5799*****88***988865335*********8888 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 0.00017
                 SS--EEE--.SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLs.nNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++Ld++ +N    i+   l+ l++L++L++ gN  i
  EFC35729.1  74 KQLTNLDIRsHNIFH-IGAkyLSELKQLTTLNIYGN-HI 110
                 57999****987766.55555888*********999.44 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00026
                 SS--EEE--SS---.E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqlt.dipl..leklpnLkeLdLsgN 33 
                 ++L++L++ +N++  +  +  ++ l +L++L + +N
  EFC35729.1  98 KQLTTLNIYGNHIGaKG-SkyISELNQLTTLFIAEN 132
                 58************443.355445*********888 PP

  == domain 5  score: 5.7 bits;  conditional E-value: 0.0096
                 S--EEE--SS---E-S-..HHH-TT--EEE-. CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLs 31 
                 +L++L ++ N +   +   l+ l++L+ L +s
  EFC35729.1 123 QLTTLFIAENSVGVEGAkyLSELKQLTNLGIS 154
                 69******99*997666766668888888774 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0   0.00025      0.57      76     123 ..      39      83 ..      23      94 .. 0.83
   2 !    9.1   0.0    0.0005       1.1      85     122 ..      95     130 ..      84     142 .. 0.87
   3 ?    0.0   0.0       0.3   6.7e+02     102     121 ..     134     153 ..     126     162 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00025
     DUF4347  76 yaeelaqwgealsedadillYgCnvAageaGeafvekLaqltgadvaA 123
                 ++ee++++ ++l++ + +++Yg ++  +  G +++++L+qlt+ d+ +
  EFC35729.1  39 EEEEVHHL-SELKQLKSLHIYGSQIRGE--GVRYISELKQLTNLDIRS 83 
                 55666666.789999**********765..***************975 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0005
     DUF4347  85 ealsedadillYgCnvAageaGeafvekLaqltgadva 122
                 ++l++  ++ +Yg +++a+  G++++++L+qlt   +a
  EFC35729.1  95 SELKQLTTLNIYGNHIGAK--GSKYISELNQLTTLFIA 130
                 567888899********98..************99987 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.3
     DUF4347 102 ageaGeafvekLaqltgadv 121
                  g +G +++++L+qlt+  +
  EFC35729.1 134 VGVEGAKYLSELKQLTNLGI 153
                 5678999*********9877 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.23   5.1e+02       1      22 [.      51      72 ..      51      73 .. 0.82
   2 ?    3.3   0.1     0.083   1.9e+02       2      22 ..      76      96 ..      75      97 .. 0.80
   3 ?    5.5   0.0     0.015        34       1      21 [.      99     119 ..      99     121 .. 0.82
   4 ?   -2.2   0.0       5.2   1.2e+04      21      21 ..     143     143 ..     123     160 .. 0.50
   5 ?   -2.3   0.1       5.8   1.3e+04      13      22 ..     209     218 ..     205     219 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.23
       LRR_1  1 nLrhLdLsnnpllglppnsfqn 22
                +L++L++ + ++ g + ++++ 
  EFC35729.1 51 QLKSLHIYGSQIRGEGVRYISE 72
                59*****999998888887765 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.083
       LRR_1  2 LrhLdLsnnpllglppnsfqn 22
                L+ Ld+++ +++++++ +++ 
  EFC35729.1 76 LTNLDIRSHNIFHIGAKYLSE 96
                899***888877999988876 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++ +n+++ +++ +++
  EFC35729.1  99 QLTTLNIYGNHIGAKGSKYIS 119
                 599********9888877776 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 5.2
       LRR_1  21 q 21 
                 +
  EFC35729.1 143 S 143
                 2 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 5.8
       LRR_1  13 lglppnsfqn 22 
                 ++l+ n+f++
  EFC35729.1 209 SDLLFNHFCH 218
                 6788899986 PP

>> Cas6  Cas6 Crispr
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.8   4.7e-05       0.1      42     107 ..      12      83 ..       5     147 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.7e-05
        Cas6  42 isgaeskng....llllsrrsrLrlRvpkeqvaellaLag.ktleigghklrlgip.klrllepastLkarl 107
                 +++ +++++    l+l+++ ++L++R+++e+v++l++L++ k+l+i g+++r      +++l++ ++L  r 
  EFC35729.1  12 LKVNATSEDtfkkLILMKSLTKLVIRIEEEEVHHLSELKQlKSLHIYGSQIRGEGVrYISELKQLTNLDIRS 83 
                 44444444455558999999*****************865389******99854431566677766665443 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.1      0.11   2.6e+02     104     146 ..      41      80 ..       5      91 .. 0.55
   2 ?    9.6   0.1   0.00027       0.6      63     126 ..      73     135 ..      47     155 .. 0.73
   3 ?    9.9   0.0   0.00022      0.49      60     125 ..      94     158 ..      71     184 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.11
       LRR_9 104 adldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                  +++ l +lk+l++l +  + +  +     + i  lkql+ ld
  EFC35729.1  41 EEVHHLSELKQLKSLHIYGSQIRGE---GVRYISELKQLTNLD 80 
                 3455566666666666655544322...223345555555555 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00027
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 lk+l  l + +  i +i+ +    l +l++l + +n++   +  + + +l++l++l + +n+v 
  EFC35729.1  73 LKQLTNLDIRSHNIFHIGAKYLSELKQLTTLNIYGNHIGAKGS-KYISELNQLTTLFIAENSVG 135
                 5666667788888888888888888888888888888888777.77888888888888888775 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00022
       LRR_9  60 fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 +  lk+l tl +  n i   + +    l +l++l +++n++   +  + l +lk+l++l +  n +
  EFC35729.1  94 LSELKQLTTLNIYGNHIGAKGSKYISELNQLTTLFIAENSVGVEGA-KYLSELKQLTNLGISVNWL 158
                 3445666666666777776666666667777777777777665444.6677777777776666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1800.66
//
Query:       EFC35730.1  [L=188]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-07   31.7   3.4      0.015   16.2   0.1    4.1  4  WD40      WD domain, G-beta repeat
      0.008   16.1   0.0        3.3    7.6   0.0    2.2  2  eIF2A     Eukaryotic translation initiation factor eIF2A


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1     0.083   7.4e+02      31      38 .]       2       9 ..       1       9 [. 0.88
   2 !   16.2   0.1   1.7e-06     0.015       7      38 .]      19      52 ..      13      52 .. 0.84
   3 !   11.0   0.0   6.9e-05      0.62      16      38 .]     100     113 ..      74     113 .. 0.78
   4 ?    1.2   0.0     0.089     8e+02      22      33 ..     154     170 ..     125     172 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.083
                TSEEEEEE CS
        WD40 31 DgtvriWd 38
                +g v++Wd
  EFC35730.1  2 NGIVKLWD 9 
                699****9 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 1.7e-06
                EESS.SSEEEEEEETTSSE.EEEEETTSEEEEEE CS
        WD40  7 ltGH.ssvtslafspdgaw.lasGsdDgtvriWd 38
                l  H + v  ++f+p++   l++G+ Dg + +Wd
  EFC35730.1 19 LVHHvKEVLNCSFNPYNGInLVTGGVDGLINVWD 52
                56688889888888888888*************9 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 6.9e-05
                 EEEETTSSEEEEEETTSEEEEEE CS
        WD40  16 lafspdgawlasGsdDgtvriWd 38 
                 +        ++sG  Dg vr+Wd
  EFC35730.1 100 I--------ISSGF-DGVVRFWD 113
                 2........55566.*******9 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.089
                 SSE.....EEEEETTSE CS
        WD40  22 gaw.....lasGsdDgt 33 
                 g+w     +++G++D++
  EFC35730.1 154 GSWsehlmVVCGGYDKK 170
                 45555555789999986 PP

>> eIF2A  Eukaryotic translation initiation factor eIF2A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0   0.00036       3.3      82     157 ..       2      78 ..       1      85 [. 0.72
   2 !    7.2   0.0   0.00046       4.2     101     142 ..      85     124 ..      71     132 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00036
                 SCEEEEEECS....CEEEEEEEEES--EEEE-TTSSEEEEE-TTSSS-EEEEEETTTTEEEEEEE-TT--EEEE-TTSSE CS
       eIF2A  82 pakvslfdlk....vkviskleeqkrNtiffspkgklvllaGfgnlaGeleiwdvkkkkkiakaeaanatlvewspdgry 157
                 +  v+l+dl+    v  +++  ++  N+ f  ++g  ++++G   l   +++wd  ++++   a+++++   ++++d  y
  EFC35730.1   2 NGIVKLWDLRtgllVANLVHHVKEVLNCSFNPYNGINLVTGGVDGL---INVWDLRNISQTIAAKQTDSNPEQFKQDPVY 78 
                 5678888887666533333444556777777777878888887666...**********999999999988888877655 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.00046
                 ES--EEEE-TT.SSEEEEE-TTSSS-EEEEEETTTTEEEEEEE CS
       eIF2A 101 qkrNtiffspk.gklvllaGfgnlaGeleiwdvkkkkkiakae 142
                 +  Nti+++p+ g+ ++ +Gf  +   + +wd  ++k i++  
  EFC35730.1  85 KLMNTIMYEPScGRSIISSGFDGV---VRFWDPISFKPISQSS 124
                 457******9769*******9755...*****99999998865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (188 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       299  (0.0166769); expected 358.6 (0.02)
Passed bias filter:                      286  (0.0159518); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.30s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 1193.09
//
Query:       EFC35731.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.2e-08   32.6   0.0    8.4e-08   31.9   0.0    1.4  1  RRM_1         RNA recognition motif. (a.k.a. RRM, RBD, or RNP
  ------ inclusion threshold ------
      0.028   14.3   0.0      0.064   13.1   0.0    1.7  1  RRM_occluded  Occluded RNA-recognition motif


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.9   0.0   9.3e-12   8.4e-08       1      62 [.      82     147 ..      82     158 .. 0.92

  Alignments for each domain:
  == domain 1  score: 31.9 bits;  conditional E-value: 9.3e-12
                 EEEESETTTSSHHHHHHHHHT..TSCEEEEEEEEE...TTTSEEEEEEEEESSHHHHHHHHHHHTTE CS
       RRM_1   1 lfVgnLppdvteeeLkelFsk..fGpiksiklvrd...etgkskgfafVeFeskedAekAlealngk 62 
                 ++++ Lp +vt +++k+lF +  +G i ++ l +    e  +s+ +afVeF+ +++ + A++ l+++
  EFC35731.1  82 IYITPLPGTVTSQQVKRLFYQnrCGVILNVHLLKHktvESFQSQTYAFVEFAHPDSVQLAMR-LQHQ 147
                 8******************9999***********9999999*******************99.7664 PP

>> RRM_occluded  Occluded RNA-recognition motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   7.1e-06     0.064       1      35 [.      79     114 ..      79     163 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 7.1e-06
  RRM_occluded   1 ertisllplsDtvnkariralveek.egeikkivLv 35 
                   +rti + pl+ tv+++++++l+ ++  g i +++L 
    EFC35731.1  79 DRTIYITPLPGTVTSQQVKRLFYQNrCGVILNVHLL 114
                   69********************99962544444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       750  (0.0418317); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1414.57
//
Query:       EFC35732.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-09   36.3   0.0    8.7e-09   35.2   0.0    1.6  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2   0.0   4.8e-13   8.7e-09      24     233 .]     154     407 ..     134     407 .. 0.76

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 4.8e-13
                    HHHHHCTTSEEEEEEEBSCTCHHHHHHHHH..............TTCEEEEECCHECSSSTTSSEEEEEECSTEEEEEEEEEEETSSSSGCEEEEE CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  24 dlltaydaDvlgLQEvdddelsriplllal..............ggflgasstsptgggggggnggavlsrfpltslfrrtfiefndlvaalrrep 105
                    +++++ + D+++LQE       +ipl  ++                    +      g+    +g+++l++  l  l       + + + +l+++ 
     EFC35732.1 154 NVFKNLNVDIICLQE-------VIPLYVIDfitkndfiknnyiiS-----DI----DGNSIDPYGVMILIKKNLPILDIKINKLTTRMGRCLINCT 233
                    55666688*******.......******99999998986443331.....22....36678889**********8885555555555555555555 PP

                    EEEEEEEEEECCCHHGHHHHHHHHHHHHHHHHHHHHHTTSEEEE.................................................... CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................................................... RF
  Exo_endo_phos 106 laakleqlniashrdhdlvrdlqllalllqvealnadrgapviv.................................................... 149
                    +a + ++l                                 + +                                                    
     EFC35732.1 234 FAKNIPNLD--------------------------------IYLkylnsinnndinsnieelekliptyaiigtvhleslsskerrhvqlneiysi 297
                    555555555................................3337777777777777778888888888888888888888888888888888888 PP

                    ............EEE-SSSTSGGGBSCGHHHHHHCTTTHH.SSCESCETTTTTTTTTTTEB-BEEEEEECHHHCCEEEEEEECCHHEEC....... CS
                    ............xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....... RF
  Exo_endo_phos 150 ............aGDfNarpsdddsrvlrtrglalapapv.glyllgggptptyvtraggsrlDrilaspalalfrsgvlppplalvrr....... 225
                                +GDfN+++s+ +   l t+   +  +++  ly++  g t+ y ++  g+rlDril ++        +++p++   ++       
     EFC35732.1 298 ynqypnteikmlMGDFNFDSSSIENDQLLTGNYKDYKDIWyYLYPNIEGKTFLYQNNRKGQRLDRILLNS-------KNYIPKEIKIIGnekliln 386
                    888888888888***********************99999****************************98.......7777777766667777777 PP

                    .............TSSCSSSB CS
                    .............xxxxxxxx RF
  Exo_endo_phos 226 .............ealtlSDH 233
                                 +  ++SDH
     EFC35732.1 387 eqdqlklkqsfslDYTCMSDH 407
                    777777777777777777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1601  (0.0892967); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2506.19
//
Query:       EFC35733.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.9e-14   53.1  30.8    2.2e-10   41.1  30.2    3.2  1  Ku_C        Ku70/Ku80 C-terminal arm
    5.9e-10   38.7   0.3    5.9e-10   38.7   0.3    2.2  2  SAP         SAP domain
    6.6e-07   29.2   0.3    6.6e-07   29.2   0.3    2.6  2  Ku          Ku70/Ku80 beta-barrel domain
  ------ inclusion threshold ------
       0.17   10.2  18.7         13    4.0   0.0    2.4  2  CDC45       CDC45-like protein
        6.6    7.6  15.2          2    9.2   3.1    2.6  2  Apc15p      Apc15p protein


Domain annotation for each model (and alignments):
>> Ku_C  Ku70/Ku80 C-terminal arm
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.1  30.2     6e-14   2.2e-10       1      77 [.     354     437 ..     354     504 .. 0.84

  Alignments for each domain:
  == domain 1  score: 41.1 bits;  conditional E-value: 6e-14
                 ---GGG---HHHHHHHHHHHHHHTT---..---SS--HHHHHHHHH-....HHHHHHHHHHHHH...HHHHH............. CS
        Ku_C   1 sydpskfpNPsLqrhykiLqalAldedlpeeledktlpkyeaidkragslleewkelfeleeedke.kkkekrkaed.......e 77 
                 +++p++f NPsLq++y+ LqalAl+   +e++ed ++p++e + k+ ++l++e+k+++ + ++d++ kk +k ++ +       e
  EFC35733.1 354 DFNPHEFTNPSLQQFYQSLQALALEHSNIEQIEDVLKPDKEGM-KKYENLMNEFKDMIFPSDYDPDsKKLTKSTTRTssskvkkE 437
                 69*************************************5555.8999*****************76656665554322234321 PP

>> SAP  SAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.3       1.4   5.1e+03       8      19 ..     194     205 ..     193     209 .. 0.58
   2 !   38.7   0.3   1.7e-13   5.9e-10       3      35 .]     517     549 ..     515     549 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.4
                 HHHHHHHHTT-- CS
         SAP   8 eLKeeLkkrGLp 19 
                 eLK++ +kr  +
  EFC35733.1 194 ELKDKIRKREFK 205
                 777776666444 PP

  == domain 2  score: 38.7 bits;  conditional E-value: 1.7e-13
                 T--HHHHHHHHHHTT--TTS-HHHHHHHHHHHH CS
         SAP   3 kltVaeLKeeLkkrGLptsGkKaeLieRLkeyl 35 
                 kl+V+ LKe++k++ L++sG K++LieR++e+l
  EFC35733.1 517 KLKVDILKEFCKQYKLKVSGSKKDLIERITEFL 549
                 9******************************97 PP

>> Ku  Ku70/Ku80 beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.2   0.3   1.8e-10   6.6e-07       5      79 ..     228     346 ..     224     369 .. 0.80
   2 ?  -13.4  14.6         5   1.8e+04      19      44 ..     456     479 ..     416     534 .. 0.56

  Alignments for each domain:
  == domain 1  score: 29.2 bits;  conditional E-value: 1.8e-10
          Ku   5 vsipVklykateeakkpkfkkldketnepvkvetkyvcsdtge.vdee...........................................divkgyey 59 
                 + ++ +ly+ +++++kp  + l+++tn+ +k etk++c+dtg+ + ++                                           d++ +yey
  EFC35733.1 228 IILNCTLYSCISKTRKPAAVHLHSDTNKLLKCETKFICQDTGTeLMRNgnnilqnelsstttttttinnnnnnnttssstneftnsssssnDMIYYYEY 326
                 677889***********************************84455445555555566667777777777888888888888888889999******** PP

          Ku  60 Ggevvpltkeelekiksfds 79 
                 Gg +  +t eel++ik+ ++
  EFC35733.1 327 GGHKSEFTLEELTNIKQLKN 346
                 *************7776323 PP

  == domain 2  score: -13.4 bits;  conditional E-value: 5
          Ku  19 kkpkfkkldketnepvkvetkyvcsd 44 
                 +++k++   k+tn+  + ++k+ +++
  EFC35733.1 456 TSKKKTATRKKTND--SKKRKKAEES 479
                 33333333333333..2222222222 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0    0.0035        13     213     287 ..     131     205 ..     119     229 .. 0.79
   2 ?    4.0  18.1    0.0035        13     126     198 ..     413     496 ..     362     533 .. 0.48

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.0035
       CDC45 213 eavlekyysqgtsygesvsslmYsLaselgredndlLWlAIvGltslelserisaeryerlrallrdeVrrlnps 287
                 +++l++  +    + + + ++++sL    +  + dl+W   + +++ + ++ri+++  e+  + l+d++r+ + +
  EFC35733.1 131 SSKLKTIERGRDLMNSEIEIQLFSLKIPANTFKFDLIWKQLIHVSDDDYTGRIQYDCLENGLKELKDKIRKREFK 205
                 4455555545555555678899***********************************************997765 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.0035
       CDC45 126 leeeeesd..eede..........eeeeeddddeeeeeeeeedeedeeedeeeskkkrk.sksdeeeesddddersrkrrrsepsa 198
                  +++++s+     +          ++eee++ ++++ ++++ +e+++++++ ++kk +  +k+++ ees++++e++ k+++ e s+
  EFC35733.1 413 SDYDPDSKklT--KsttrtssskvKKEEEEEATTAAADSQDVSESTSKKKTATRKKTNDsKKRKKAEESEEEEEKKPKKKKAELSE 496
                 33333333220..1222222222222222222222222222222222222222111111111222222333333333333333122 PP

>> Apc15p  Apc15p protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   3.1   0.00056         2      20      96 ..     281     349 ..     265     350 .. 0.59
   2 ?    3.3   4.4     0.039   1.4e+02      17      66 ..     449     496 ..     417     526 .. 0.49

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00056
      Apc15p  20 ksnsssernkklnngnatn...kakernedqkksrrsgyapplsaynaieespyyprggkldelrmeeeqmerrlkaIrn 96 
                 +++ ss++++        +   +++++n++ ++s+++ +++++s+  +     yy  gg+ +e+++ee    ++lk+I++
  EFC35733.1 281 QNELSSTTTT--------TttiNNNNNNNTTSSSTNEFTNSSSSSNDM---IYYYEYGGHKSEFTLEELTNIKQLKNITK 349
                 2222222222........223233444555666666666666666555...34445899*********999999999986 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.039
      Apc15p  17 esnksnsssernkklnngnatnkakernedqkksrrsgyapplsaynaie 66 
                 ++    s+s+++kk    ++tn++k+r++ ++++++++  p  + ++++e
  EFC35733.1 449 SQD--VSESTSKKKTATRKKTNDSKKRKKAEESEEEEEKKPKKKKAELSE 496
                 222..222222222222222222334444444444444444444444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3252  (0.181382); expected 358.6 (0.02)
Passed bias filter:                      619  (0.0345251); expected 358.6 (0.02)
Passed Vit filter:                       175  (0.00976072); expected 17.9 (0.001)
Passed Fwd filter:                        37  (0.0020637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.08u 0.34s 00:00:01.42 Elapsed: 00:00:00.54
# Mc/sec: 3103.30
//
Query:       EFC35734.1  [L=657]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.023   14.6   0.0          2    8.4   0.0    2.9  2  Intein_splicing  Intein splicing domain
       0.22   10.1   0.6       0.35    9.5   0.6    1.2  1  PSII             Photosystem II protein


Domain annotation for each model (and alignments):
>> Intein_splicing  Intein splicing domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.0   0.00022         2      66      94 ..     297     346 ..     288     451 .. 0.67
   2 ?    2.0   0.0      0.02   1.8e+02      48      72 ..     538     562 ..     490     575 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00022
                      -EEEECCTTEEEEEECCC--TT-EEEEE.....................H CS
                      xxxxxxxxxxxxxxxxxxxxxxxxxxxx.....................x RF
  Intein_splicing  66 HkllvvrdegivEkradeLkegdliavp.....................d 94 
                      H  l+v++ +  Ek  +eLke +li+v                      +
       EFC35734.1 297 HAQLIVDKSKYWEKAKQELKEDELIVVMdfasgwevidkavettneffeK 346
                      778889776666***************94444444444444444444440 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.02
                      EEEEEEETTS-EEEEETT-EEEECC CS
                      xxxxxxxxxxxxxxxxxxxxxxxxx RF
  Intein_splicing  48 elyeiklesgrkikaTpeHkllvvr 72 
                       + +++l  ++  k+Tp+H+l+  +
       EFC35734.1 538 VIKNVNLITNSGGKLTPNHCLFCNK 562
                      455555555666678*******985 PP

>> PSII  Photosystem II protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.6   3.9e-05      0.35      75     130 ..     327     379 ..     321     385 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 3.9e-05
        PSII  75 wggwevvgetvtdpglysfegvavaHlvlsallflaaiyHfvewDlelfkdkrtge 130
                  +gwev++++v+ ++ + fe+  +  +++  +  l++ +H++++D  l +d++t++
  EFC35734.1 327 ASGWEVIDKAVETTNEF-FEKHYIKDMIVVVVRKLGGEFHYTYFD--LINDNHTSD 379
                 68******877766655.89999999*******************..778877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (657 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1375  (0.0766914); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.29s 00:00:01.01 Elapsed: 00:00:00.48
# Mc/sec: 4096.33
//
Query:       EFC35735.1  [L=420]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0011   18.5   0.8     0.0011   18.5   0.8    2.1  2  Sec62     Translocation protein Sec62
  ------ inclusion threshold ------
       0.03   14.3   0.2        2.1    8.4   0.4    2.8  2  Surp      Surp module
       0.21    9.9  14.4       0.34    9.1  14.4    1.4  1  CDC45     CDC45-like protein
       0.52    9.6  25.3       0.66    9.3  25.3    1.0  1  BUD22     BUD22


Domain annotation for each model (and alignments):
>> Sec62  Translocation protein Sec62
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   3.4      0.79   3.5e+03      31      98 ..      76     144 ..      46     155 .. 0.42
   2 !   18.5   0.8   2.5e-07    0.0011      10     157 ..     174     326 ..     167     341 .. 0.60

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.79
       Sec62  31 lkevkkkekaekvfkelkksqlalrvekl....kekekkkkkeekkkkkkkkkkvkleieeeqefvddnevY 98 
                 ++ev  k +  ++   + + +l+ + +++     ++e+k   ++  +kk+   +vkl   e+ e+vd+ ++Y
  EFC35735.1  76 KEEVFAKPEVMNILDDIFNVKLQGKYNNNiteyVAQEEK---HSLGEKKQVDVEVKLFDDEDEELVDKPAIY 144
                 222222222222222222222222222221100222211...123444445555555555666666665555 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 2.5e-07
       Sec62  10 kvvralksekekkkskkkkeklkevkkkekaekvfkelkksqlalrveklkekekkkkkee.....kkkkkkkkkkvkleieeeqefvddnevYvWiYe 103
                 + v+++ks +++k+++kk + l++ ++++++++++++l++++ + + +++  k+k+++  +     ++k kk+ k  k+   ++ +  d +  Y  + +
  EFC35735.1 174 RQVQKEKSGHKRKRKEKKFSFLEDSDDEDEEHDKSIALNDEDEESDEDEDLLKNKAAE--ThnfisSTKVKKSEKPNKVAKRHKEQN-DRKRLYSDFNN 269
                 3444444544444444444455555555554555555555544444444422222222..133665444444444555555555555.8********** PP

       Sec62 104 pkqlktlligl....lvvvailavvlFPLWPaelrkgvyYLSiaalgllglilalaiv 157
                 ++ l ++l+      +v +a+  +vl+P+  a+  + + Y+S   +g+  +++ l++ 
  EFC35735.1 270 GVLLIYYLMFPvmypIVTLAVPSIVLYPIF-AFYETYALYISENSTGFWSMMISLTVT 326
                 *99888876431111456677789*****9.567889999**9999999999999875 PP

>> Surp  Surp module
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.4   0.00046       2.1      19      40 ..     179     200 ..     163     206 .. 0.75
   2 ?    2.5   0.0     0.032   1.4e+02       6      23 ..     304     321 ..     303     325 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00046
                 HHHHHHH.T--TTSGGGSTT.S CS
        Surp  19 eqklrerernnpqFaFLkdpdh 40 
                 e+  ++r+r++ +F+FL d+d+
  EFC35735.1 179 EKSGHKRKRKEKKFSFLEDSDD 200
                 4444677888*******88864 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.032
                 HHHHHHTT-S.SHHHHHH CS
        Surp   6 ktAqfVarnGkeFeqklr 23 
                 + A ++++n   F+++++
  EFC35735.1 304 TYALYISENSTGFWSMMI 321
                 679************987 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1  14.4   7.6e-05      0.34      94     218 ..     143     262 ..      79     282 .. 0.43

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 7.6e-05
       CDC45  94 lfgsseekerivvfDDgdi......eeeleeereayealeeeeesdeede........eeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdee 178
                 ++ +++++ +i  fDD d       +++l+e + + e+  ++ +     +        +++  d+d                                 
  EFC35735.1 143 IYDENQKEVKIKLFDDIDDdddvpfKDQLKERQVQKEKSGHKRKR----KekkfsfleDSD--DED--------------------------------- 202
                 333444555555555544311112222222211111111111111....011233321111..111................................. PP

       CDC45 179 ee..............sddddersrkrrrse...................psakklrrq.lkkerrkyeavlek 218
                  e              s             +                   ++ kk+++  + ++r+k ++  ++
  EFC35735.1 203 -EehdksialndedeeS-------------DededllknkaaethnfissTKVKKSEKPnKVAKRHKEQNDRKR 262
                 .1111111111111001.............01111111122222333322111111111222222222222222 PP

>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3  25.3   0.00015      0.66      91     279 ..      49     254 ..      10     266 .. 0.57

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00015
       BUD22  91 ksnpeekneelektkalenvtsrLlnsktvkevveeivesvkkllgiek.kkkkkeeekkkkkkkkkkkkkkeeeeeeesdkeeesedsed...eekee 185
                 ++ p+ + ++  ++++  n +s+L   k+   + +e+++ ++ +++++   k++++  +  ++++k++ ++k++ + e++  ++e+e+  d     +e+
  EFC35735.1  49 SMVPNVIINKKYDNQQQMNGMSKLQIEKEEVFAKPEVMNILDDIFNVKLqGKYNNNITEYVAQEEKHSLGEKKQVDVEVKLFDDEDEELVDkpaIYDEN 147
                 444444456666667777888888888888888899999999999999986777777777777777777777777766666666666666655422222 PP

       BUD22 186 seddeeeeeededdedaee...............deedeeaeerelaqydgllasddededeyneetdeesseesdssdssesasesesessek..kkk 267
                 +++ + + ++d dd+d+                 ++++++++e++++ +++   sddede+++++   ++++eesd++++  + +++e+ +  +  k k
  EFC35735.1 148 QKEVKIKLFDDIDDDDD-VpfkdqlkerqvqkekSGHKRKRKEKKFSFLED---SDDEDEEHDKSIALNDEDEESDEDEDLLKNKAAETHNFISstKVK 242
                 22333333333333332.247777777777665555556666666666666...******944444444444444444444443333322211122222 PP

       BUD22 268 kkkkkkkkakak 279
                 k++k +k ak  
  EFC35735.1 243 KSEKPNKVAKRH 254
                 222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (420 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2241  (0.124993); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.46
# Mc/sec: 2764.52
//
Query:       EFC35736.1  [L=108]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.6e-14   53.1   0.0    2.9e-14   53.0   0.0    1.1  1  Aldo_ket_red  Aldo/keto reductase family


Domain annotation for each model (and alignments):
>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.0   0.0   1.6e-18   2.9e-14       1      70 [.      28     105 ..      28     108 .] 0.94

  Alignments for each domain:
  == domain 1  score: 53.0 bits;  conditional E-value: 1.6e-18
                   .EEEE-SSS-ST.........TS-HHHHHHHHHHHHHTT--EEE--TT-TTTHHHHHHHHHHHH-TTTGGG-EEEEEE CS
  Aldo_ket_red   1 elglGtwqlgsk........eeiskeealellrraleaGinffDtAevYgkgqseellGealkksrkkreeviiatKv 70 
                   ++ lGt+++g             ++ee  ++  r+l+aG nf+DtA++Y++g+se+l+G+ +kk + +r e++iatK 
    EFC35736.1  28 PIALGTGHFGHNavfstsmgVGSTDEENEKIFLRYLQAGGNFIDTANLYQDGESEKLIGQLIKKHNIDRNELVIATKY 105
                   6899999999989999999878889999999**********************************************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       305  (0.0170115); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 720.18
//
Query:       EFC35737.1  [L=218]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-19   69.7   0.1    2.8e-19   69.4   0.1    1.2  1  START     START domain


Domain annotation for each model (and alignments):
>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.4   0.1   1.5e-23   2.8e-19      62     183 ..      68     192 ..      16     205 .. 0.77

  Alignments for each domain:
  == domain 1  score: 69.4 bits;  conditional E-value: 1.5e-23
                 HHHHCCCGGGTTCT-TT-SEEEEEEEECTTEEEEEEEE--TT..-SS-EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEE CS
       START  62 veellkdaeyraqWdktlasaetvevissggalqlyvaelvalsplspRdfvflRsirelgdgsyvivdrSvtseqnppesssvvRaellpSgiliepl 160
                 ++ l++++    + ++ l +++ ++++++ +++++   + ++   +s Rd+++ R  ++ +dgs v++  Sv  ++  pe+s++vR+ ll+Sg++i+p+
  EFC35737.1  68 ANVLWDSN-HVLKLSTSLSEIKSLKKVEDIEVVVHSHKSPAF--GVSKRDYLICRRLKKREDGSIVLCQKSVVDNALYPEQSGYVRGDLLVSGYVIKPV 163
                 34444444.223334445577777777766777777666666..6777***********************8777766669****************** PP

                 CTCE......EEEEEEEXEEXXSSXXHHH CS
       START 161 gngh......skvtwvehvdlkgwlpkwl 183
                 +++       + vt+v ++d+kgw+p+ +
  EFC35737.1 164 KKPNettatsCHVTYVIQTDVKGWIPDFV 192
                 **************************533 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       417  (0.0232584); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1359.99
//
Query:       EFC35738.1  [L=279]
Description: silent information regulator family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.7e-19   68.0   0.5    9.7e-12   45.2   0.1    3.3  2  SIR2             Sir2 family
     0.0017   18.1   0.0       0.12   12.1   0.0    2.3  2  TPP_enzyme_M     Thiamine pyrophosphate enzyme, central domai
  ------ inclusion threshold ------
      0.038   14.4   0.1       0.09   13.2   0.1    1.6  2  Goodbye          fungal STAND N-terminal Goodbye domain
        1.3    9.3   5.0        3.2    8.1   3.4    2.1  2  DNA_pol_delta_4  DNA polymerase delta, subunit 4


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   9.1e-06     0.041       1      24 [.      65      88 ..      65      98 .. 0.90
   2 !   45.2   0.1   2.2e-15   9.7e-12      54     177 .]      99     212 ..      89     212 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 9.1e-06
                -GGGGGGGT---SSSTTSHHHHSC CS
        SIR2  1 GAGiStesGipdfRskeGlyakla 24
                GAGiSt++ + d+R+ +G+++ ++
  EFC35738.1 65 GAGISTSAQLSDYRGPKGVWTAME 88
                9*******************9764 PP

  == domain 2  score: 45.2 bits;  conditional E-value: 2.2e-15
                 CCTSS--HHHHHHHHHHHTTCEEEEEES-SSSHHHHTT-SSEEETTEEEEEEEETTTSBEE....ECCGGHCHHHCCTT.B-TTTCCBEEEEE--CTSB CS
        SIR2  54 aeeaepnaaHkalkklekkgkllrliTQNiDgLekkaGskkvvelHGslakakcvkcekkl....dkeelqeeieaekvpecekcgkllkpdvvfFGea 148
                  e+a p+ +H+a+++l kk+ ++ ++  N+DgL++                  c+kc+k++    d ++ +++ +++ +++ ++cg+ lk +++ F e+
  EFC35738.1  99 IEQAVPTYCHYAITHLVKKDYVKYVVSTNVDGLHNV---------------EYCNKCDKEYlrgfDVSKNEKDWTKHFTGRKCECGGRLKDNIIHFDED 182
                 45899****************************974...............3566666654222266777788888888999***************** PP

                 -S.HHHHHHHHHHHH-SEEEEES--STSTT CS
        SIR2 149 lp.dklkkliekveeadlllviGtSlkVap 177
                 lp + +++++++ ++ d  lv+GtS+kV+p
  EFC35738.1 183 LPeKDFDQAMDHSKKGDFALVLGTSMKVTP 212
                 **999***********************98 PP

>> TPP_enzyme_M  Thiamine pyrophosphate enzyme, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   2.6e-05      0.12       1      25 [.      47      71 ..      47      77 .. 0.89
   2 ?    3.6   0.0     0.011        51      70     135 ..     190     254 ..     177     256 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 2.6e-05
                  HHHHHHHHHH-SSEEEEE-CHHCHT CS
  TPP_enzyme_M  1 iekaaellkaakrpvilvGggvars 25
                  ++k+a++lk+ak +vi+ G g+++s
    EFC35738.1 47 VKKLANYLKEAKHVVIYTGAGISTS 71
                  689******************9966 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.011
                   HHHHHHHH-SEEEEES-SSSTCCCTTTTT.TTTTT-.EEEEEESSCCCCTTCC--SEEEECTHHHHHH CS
  TPP_enzyme_M  70 aanealeeaDlvlalGarfddirttgsep.efapea.kiihididpaeigknyqvdlaivgdvketle 135
                   +a ++ ++ D+ l+lG+ ++ + + + +p e+  ++  +  ++ +++e ++    ++ i+g+ + +++
    EFC35738.1 190 QAMDHSKKGDFALVLGTSMKVTPSCE-FPlEVLDNKgMMCIVNLQKTEYDRLA--TVRIFGKTDLFMQ 254
                   566677889**********9966665.55477777767778888888888875..6788877776665 PP

>> Goodbye  fungal STAND N-terminal Goodbye domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1     2e-05      0.09      14      93 ..      13      93 ..       5     103 .. 0.87
   2 ?   -2.8   0.0       1.9   8.6e+03      77     104 ..     246     273 ..     226     276 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2e-05
     Goodbye 14 kdlkdealkelssvedllkqieaekdkfeefrekkeklkealkkilspiqllggiaaqgasma.FgPaslcfnAvsyLika 93
                ++ + e+ +e++++ +l +++++++++ ++ ++k +kl ++lk++ +++   g  +++ a+++ +   + + +A+ y ++ 
  EFC35738.1 13 SQTTSEKASEPAKPKELPASLKEHEESETSIKRKVKKLANYLKEAKHVVIYTGAGISTSAQLSdYRGPKGVWTAMEYGVEE 93
                3344788999****************99999*******************************9999999999999886665 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.9
     Goodbye  77 FgPaslcfnAvsyLikaakkvseiydai 104
                 Fg ++l+++ ++  ++  ++v++++da+
  EFC35738.1 246 FGKTDLFMQLLMTELEEEENVDTSFDAL 273
                 5555555555555566666666666665 PP

>> DNA_pol_delta_4  DNA polymerase delta, subunit 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   3.4   0.00071       3.2      13      61 ..       5      53 ..       1      72 [. 0.73
   2 ?    0.1   0.0      0.21   9.6e+02      53      86 ..     117     152 ..      95     153 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00071
  DNA_pol_delta_4 13 evdkekkvssaekeevaetkepekleeelkaekelekqidkewkkieee 61
                     +++k+k++s++++e+  e ++p++l ++lk+++e+e++i+ + kk+++ 
       EFC35738.1  5 SKKKSKSSSQTTSEKASEPAKPKELPASLKEHEESETSIKRKVKKLANY 53
                     3444455555556666666889999999999999999999999988764 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.21
  DNA_pol_delta_4  53 kewkkieeerkappvHa.eelskvek.vLreFDvss 86 
                      k + k         +H+ e  +k++k  Lr FDvs 
       EFC35738.1 117 KDYVKYVVSTNVDGLHNvEYCNKCDKeYLRGFDVSK 152
                      44445555555677888777888876479****996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1534  (0.0855597); expected 358.6 (0.02)
Passed bias filter:                      878  (0.0489709); expected 358.6 (0.02)
Passed Vit filter:                       105  (0.00585643); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 1695.39
//
Query:       EFC35739.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.6e-51  175.5   6.7      2e-51  175.2   6.7    1.1  1  Peptidase_C1    Papain family cysteine protease
    2.9e-06   26.3   1.4      0.042   12.6   0.0    2.2  2  Peptidase_C1_2  Peptidase C1-like family
    0.00012   21.9   0.1    0.00027   20.7   0.1    1.6  1  Propeptide_C1   Peptidase family C1 propeptide


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  175.2   6.7   3.4e-55     2e-51       1     216 [.     103     320 ..     103     322 .. 0.86

  Alignments for each domain:
  == domain 1  score: 175.2 bits;  conditional E-value: 3.4e-55
                   STSCEETTTTTTG.SG---B-TSSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS--SSSC CS
  Peptidase_C1   1 lpesvDwrekgga.vtpvkdqgsCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdypYkake 95 
                   +p ++D+r++    v +++dq++CG+CWafsa  +l  rl+i+t+ +++v lS +  v+C++ +n+ C+GG+ ++++ +++++g   +++ pY + +
    EFC35739.1 103 IPMNFDARTQWRGcVPAIRDQQTCGACWAFSANYVLAHRLCIATNgQTNVVLSPEYQVQCDT-MNKACQGGYLKYSWTFLENTGTPLDTCIPYASGR 198
                   6999*****55434*******************************99**************9.9******************************877 PP

                   S....SS-CGCGGGSEEBEESEEEEEESS...BHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEEEEEETTEEEEEEE CS
  Peptidase_C1  96 g....gkCkkkkkkekvakikgygkvken...seealkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivGygvengkkyWivk 185
                   g    g+C ++ k ++ +++++y+  + +     +++k+a++++g v++ +++++ d+  YksGvyk+  +s+    hav+++G+gve+g++yW+++
    EFC35739.1 199 GtfssGTCPTQCKIAS-MSMSKYKAKNTRyitGINNIKTAIMTYGSVQAGFTVYR-DLTGYKSGVYKHV-VSTVLGGHAVALIGFGVEGGSNYWLAA 292
                   7788856655543333.3344443333333344689*******************.6***********6.555678********************* PP

                   -SBTTTSTBTTEEEEESSSSTGGGTTSSEEE CS
  Peptidase_C1 186 NsWgtdwgekGYiriargknnecgieseava 216
                   NsWg++wg++GY++ia+g+    gie++++a
    EFC35739.1 293 NSWGANWGMSGYFKIAQGEG---GIENQVYA 320
                   ****************9965...99998876 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0     7e-06     0.042      57     105 ..     119     168 ..      85     173 .. 0.83
   2 !   12.5   0.4   7.6e-06     0.045     360     398 ..     272     308 ..     250     311 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 7e-06
                     S--B--BSSTHHHHHHHHHHHHHHHH.HCT-SS--B-HHHHHHHHHHHHH CS
  Peptidase_C1_2  57 evtnqkqsGRCWlFaalnvlRlkllk.klklkefelsqaylffwDklEka 105
                      + +q++ G CW F+a  vl ++l   +    ++ ls  y+   D ++ka
      EFC35739.1 119 AIRDQQTCGACWAFSANYVLAHRLCIaTNGQTNVVLSPEYQVQCDTMNKA 168
                     5789*****************99865055577999*****9999999887 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 7.6e-06
                     -EEEEEEEEEE-TTSSEEEEEEE-SBTTTSTBTTEEEEE CS
  Peptidase_C1_2 360 tHamvltgvdvdddgkvtkwkvEnsWGedsGekGyfvms 398
                      Ha+ l+g+ v  +g  + w   nsWG + G  Gyf ++
      EFC35739.1 272 GHAVALIGFGV--EGGSNYWLAANSWGANWGMSGYFKIA 308
                     6*********9..888999*****************875 PP

>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.1   4.6e-08   0.00027       3      31 ..      45      76 ..      44      79 .. 0.93

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 4.6e-08
                   HHHHHHHHHC.T-SEEE---..-SSBSHHHHH CS
  Propeptide_C1  3 defIdyiNsk.nttWkAgrN..Fdnttlsyik 31
                   +++Id iNs+   +WkA  +  Fdn t+s+++
     EFC35739.1 45 KSLIDRINSNhTHGWKATEYsrFDNMTISQLR 76
                   689*******9999****************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       577  (0.0321825); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2072.69
//
Query:       EFC35740.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.2e-13   48.9   0.1      9e-11   41.8   0.1    2.3  1  NTP_transferase  Nucleotidyl transferase


Domain annotation for each model (and alignments):
>> NTP_transferase  Nucleotidyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.8   0.1     5e-15     9e-11       3     239 ..       7     315 ..       5     323 .. 0.70

  Alignments for each domain:
  == domain 1  score: 41.8 bits;  conditional E-value: 5e-15
                      EEE--S--GGGTTCCTTSSGGGSEETTET.....E....TTHHHHHHHHH....TT-SEE..EEEEETTTHHHHHHHHTTSGGGT......... CS
  NTP_transferase   3 vILaGGsGtRLwPLtrtlakklvpvlgke.....r....liqatlsrlan....sgieei..ivvltqehsflveeqlkegskfg......... 72 
                      +I   G GtR++P ++ ++k l+p+l+ +     +    +i++ +++l++     g+++i   +v++++++ ++ee +++   f+         
       EFC35740.1   7 IIPIAGHGTRMFPASKVMPKALFPILDPKdklckPilliIIEHAVEALLAeqpqIGWDDIqvCIVMQENQRSIIEEFFNAPCAFSmegkakeiq 100
                      66678*********************9765222242222356666666653332345554315566666667777777777777799******* PP

                      ..........SEEEEEEESS--BGGHHHHHTHHHHTTSSE..EEEEETTEEEEST.......THHHHHHHHHTHSSTTSEEEEEEESS-CTTSE CS
  NTP_transferase  73 ..........vevlialepegkgtAdAvalaaelledeksdelvlvLggDhlikd.......ayeeavkkaiekaakgtvtfgivpveeateyG 149
                                 ++++++++e+ g  +A++  a+ + +e+  e ++vL gDh+++         ++ av+ + + ++  +vt+ +  ++   + G
       EFC35740.1 101 dsmrmiekisKTLTFIVQEEQLGFGHALLCCADKFIKEN--EAFIVLLGDHIYTSrtqsgksCLQYAVRAFNKFNK-AIVTLDTISEKHTYANG 191
                      ********888999****************999999998..49**********99888555334445555544444.6899999999999999* PP

                      EEEEC.....TTS....BEEEEECS-SSHSH.........................CSEECCSEEEEETTHHHHHHH..CCHHHTTSSCHHHHH CS
  NTP_transferase 150 viead.....eeg....rverfvEKPkeaka.........................selassGiYvfnsevllflak..dleelkrgedeitdi 207
                      v +++     e++     + + +EKP++ +                            +   Gi + + ev+  l +  ++ +l++ge ++ ++
       EFC35740.1 192 VLKIGqvlekESEvvytSILTTIEKPNKIQCenhnlyiteeelqmlevertcknenDVVCYFGIDILTYEVFTHLREnwKCGKLHNGELNLREA 285
                      *****99976333778899********9887666667776666666666666665533344455555555555554435556666666666666 PP

                      HHHHHHTTEEEEEECSTTEE-EEEXSSHHHHH CS
  NTP_transferase 208 lpkaleegkvalaflfkdaeyWsDvGtldsll 239
                      +   +e+g+    f++++++   D+G +  ++
       EFC35740.1 286 MCPTIERGDMVGVFVRDASR--HDTGLPFEYW 315
                      66666666666666666654..5666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       798  (0.0445089); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 2233.29
//
Query:       EFC35741.1  [L=277]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-07   29.6   0.1     0.0015   18.5   0.1    3.0  2  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.1   8.2e-08    0.0015       6      27 ..     124     146 ..     119     147 .. 0.92
   2 !    8.0   0.0   0.00017         3       9      27 ..     197     215 ..     189     216 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 8.2e-08
                 EEEEE.TTTEEEEEECCCTEEEE CS
         NHL   6 Gvavd.snGdiyVaDsenhrvqv 27 
                 G++v+  nGd+y++D +nhr+++
  EFC35741.1 124 GISVNpMNGDVYICDINNHRIRK 146
                 9999*99**************86 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00017
                 EETTTEEEEEECCCTEEEE CS
         NHL   9 vdsnGdiyVaDsenhrvqv 27 
                 vds Gd+y aD++n  +++
  EFC35741.1 197 VDSKGDVYFADTYNGLIRK 215
                 89************99975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       479  (0.0267165); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.25s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1840.24
//
Query:       EFC35742.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      0.002   17.6   0.0     0.0037   16.7   0.0    1.4  1  PTase_Orf2  Aromatic prenyltransferase Orf2
     0.0068   16.9   0.3      0.061   13.8   0.0    2.7  2  DUF1660     Prophage protein (DUF1660)
  ------ inclusion threshold ------
      0.057   12.9   0.1      0.084   12.3   0.1    1.2  1  T6SS_VasJ   Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A01


Domain annotation for each model (and alignments):
>> PTase_Orf2  Aromatic prenyltransferase Orf2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   6.3e-07    0.0037      86     151 ..     137     199 ..     111     226 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 6.3e-07
  PTase_Orf2  86 llaeWsslkkgapvesiDfdvgkGlkKvWvyfGgerpledllglenvPeslrqhekkfleagldkv 151
                 +la+W +++++   esi+ + ++ ++  Wv+   e+ le ++ l++ P+ +++h +++ +  ldkv
  EFC35742.1 137 ILAHWYAVYQK---ESIELNSAQYFESEWVFNNREQCLESVAILKSYPKYIQKHINRYSQEELDKV 199
                 57789888765...7788**********************************************98 PP

>> DUF1660  Prophage protein (DUF1660)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0     1e-05     0.061      25      62 ..     170     208 ..     157     210 .. 0.81
   2 ?   -1.1   0.0      0.46   2.7e+03      17      28 ..     228     239 ..     217     254 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1e-05
     DUF1660  25 CeRC.eivkekvkclekklnrsdLdesenvfpekWLDKh 62 
                 C     i+k++ k ++k++nr++ +e ++vfp+k + K 
  EFC35742.1 170 CLESvAILKSYPKYIQKHINRYSQEELDKVFPKKIISKR 208
                 554445668888999*******************99886 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.46
     DUF1660  17 aadseelyCeRC 28 
                 + ++++ +C +C
  EFC35742.1 228 TGSTTPTFCIKC 239
                 45567779**** PP

>> T6SS_VasJ  Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   1.4e-05     0.084     132     196 ..      11      81 ..       6      98 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.4e-05
   T6SS_VasJ 132 LsFsDgtPFadeetraWlaeea......aseavaesaatsesadedlaealelaaeegleaalsllqqala 196
                 L F+Dg   +d e r+W+ e++      ++ a+++  ++++s++++l++    ++ ++l++++++ + ++a
  EFC35742.1  11 LLFQDGLRMIDIESREWILEQVdfdqdwQYVACSNVYSKKKSTNSQLERTNVSMNLKNLKDYIDWKECKQA 81 
                 88********************8888887777777777777777788888888888888888888665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1139  (0.0635284); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 1861.22
//
Query:       EFC35743.1  [L=279]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.5e-24   85.4   0.1    7.2e-24   85.1   0.1    1.1  1  2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.1   0.1     4e-28   7.2e-24       1     196 []      65     258 ..      65     258 .. 0.79

  Alignments for each domain:
  == domain 1  score: 85.1 bits;  conditional E-value: 4e-28
  2OG-FeII_Oxy_2   1 glllipnflsaeeaaellrelleegpfrqptilggkrvsvqqtllgplgwatdgpgyrysekesvdakplspfpeallrlverlvkaag...peg 92 
                     g+++i+n++s+ee  ++++ + ++  ++++ +++++ + +++    + +  +++++ + s+  +++   l++f      l+erlv+++g    + 
      EFC35743.1  65 GAIYIKNYISEEEEERIMKLI-DSKAWCHEICRRTQMYGYTYY--HTRHNLPTMQPVNESSS-NYQHLDLKEFDW----LIERLVERDGlykTDY 151
                     689*********987777655.5999***********999864..33444444444444433.444444444333....3334444444333566 PP

  2OG-FeII_Oxy_2  93 wspnaalvnfYrdgariglHqDkeesaleapivSlSLGasatfrfgkesreeeiiailLesGdllvmggesrkay.Hgvprikkdtapele...l 183
                      +p+++lvn Y  ++ i+ H+D+  + +++ i  +SL +++++ ++ +s+e+ +++ilLe+ +l vm+ +sr  + Hg++++k+   p+     +
      EFC35743.1 152 GNPTQCLVNEYIGTQGISSHVDNPGP-FGDIITLVSLNKPIYMVLKLASNENIQTKILLEPRSLFVMKDDSRFKWkHGITHMKQVYVPSTGetlI 245
                     79**********************99.*********************************************************84444335669 PP

  2OG-FeII_Oxy_2 184 eelrtrRinlTfR 196
                     +++++rR++lTfR
      EFC35743.1 246 RDENYRRVSLTFR 258
                     999*********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       550  (0.0306766); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1723.37
//
Query:       EFC35744.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.6e-06   25.3   0.1     0.0016   18.0   0.0    2.1  2  Exo_endo_phos    Endonuclease/Exonuclease/phosphatase family
     0.0053   16.6   0.0       0.57   10.0   0.0    2.1  2  Exo_endo_phos_2  Endonuclease-reverse transcriptase


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   1.8e-07    0.0016       2      86 ..      22     112 ..      21     125 .. 0.69
   2 !    5.6   0.1    0.0011        10     197     233 .]     135     165 ..     123     165 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.8e-07
                    EEEESTG.....CHHHHTHHHHHHHHHHHHHHCTTSEEEEEEEBSCTCHHHHHHHHH................TTCEEEEECCHECSSSTTSSEEE CS
                    xxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................xxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos   2 twNvngq.....aspalgssrrsdrladlltaydaDvlgLQEvdddelsriplllal................ggflgasstsptgggggggngga 76 
                    ++Nv ++      s+        + l + l++++ D+++L+Ev+ d++   pl  +                 ++          + g ++++   
     EFC35744.1  22 SFNVHHFstaygRSN-------LTELYKYLHKNNFDIVCLNEVYEDSEYSHPLRDLVyalnsslpeevevarpYQ---------YRSGPTNYESNI 101
                    899999843332222.......2225555555566************9999988877777777777775543322.........34668889999* PP

                    EEECSTE.EEE CS
                    xxxxxxx.xxx RF
  Exo_endo_phos  77 vlsrfpl.tsl 86 
                    +ls++p+ ++ 
     EFC35744.1 102 ILSKYPIlFQE 112
                    ******95444 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0011
                    B-BEEEEEECHHHCCEEEEEEECCHHEECTSSCSSSB CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 197 srlDrilaspalalfrsgvlppplalvrrealtlSDH 233
                     r+D+++ +++l++   ++ +++ a+       +SDH
     EFC35744.1 135 TRIDYVISNTELEPYLKQSWIDSDAS------GISDH 165
                    59********************9965......45**9 PP

>> Exo_endo_phos_2  Endonuclease-reverse transcriptase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.8   0.0    0.0027        24      31      81 ..      13      63 ..       2      92 .. 0.69
   2 !   10.0   0.0   6.3e-05      0.57      86     118 ..     132     168 ..     115     169 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0027
  Exo_endo_phos_2 31 p..kiiilGDfNakhplWgsedtdssargeeLiefleehslsll..nllksgptf 81
                     +  +++ ++ fN++h +      +  ++ +eL+++l++++  ++  n++ +  ++
       EFC35744.1 13 EsnNLLSCCSFNVHHFSTAY--GR--SNLTELYKYLHKNNFDIVclNEVYEDSEY 63
                     34577788899999988777..44..789*********99997733444444444 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 6.3e-05
  Exo_endo_phos_2  86 g.sstiDltltsdnlals...kleleeedlgSDHrpi 118
                      + ++ iD ++++++l      ++++++    SDH+p+
       EFC35744.1 132 RlDTRIDYVISNTELEPYlkqSWIDSDASGISDHLPV 168
                      23789*********99999999*************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       351  (0.0195772); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1187.96
//
Query:       EFC35745.1  [L=331]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        6.4    7.0   7.6       0.27   11.4   0.5    2.5  3  Cnn_1N    Centrosomin N-terminal motif 1


Domain annotation for each model (and alignments):
>> Cnn_1N  Centrosomin N-terminal motif 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.3      0.55   9.8e+03      47      66 ..      19      38 ..      10      43 .. 0.55
   2 ?   -2.5   0.0      0.34   6.1e+03      34      58 ..     217     241 ..     210     248 .. 0.67
   3 ?   11.4   0.5   1.5e-05      0.27       3      23 ..     265     285 ..     264     324 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.55
      Cnn_1N 47 elkveveslqkelkekkkll 66
                   +e e+ q+ +  ++++l
  EFC35745.1 19 VETEEFENDQNRVSLRRRKL 38
                44455555555555555555 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.34
      Cnn_1N  34 seeqkeellkenielkveveslqke 58 
                 ++ ++e+l+++ i l+  +e+  ++
  EFC35745.1 217 AQMSQEDLIAKIIRLEGIIEDRDNT 241
                 4566788888888887666666555 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 1.5e-05
      Cnn_1N   3 rEqeeqidkLkKENFdLKLri 23 
                 +E+ +qi++L+KEN dLK  +
  EFC35745.1 265 QELFQQINRLNKENCDLKCTL 285
                 67889*************766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (331 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1467  (0.0818227); expected 358.6 (0.02)
Passed bias filter:                      592  (0.0330191); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1916.56
//
Query:       EFC35746.1  [L=149]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00014   21.8   9.6    0.00023   21.1   9.6    1.4  1  EGF_Tenascin  Tenascin EGF domain
    0.00042   20.6  10.7    0.00078   19.8  10.7    1.5  1  EGF_2         EGF-like domain
  ------ inclusion threshold ------
      0.019   14.8   0.3      0.028   14.3   0.3    1.2  1  ECSCR         Endothelial cell-specific chemotaxis regulator
      0.023   15.3   2.8      0.023   15.3   2.8    1.9  2  hEGF          Human growth factor-like EGF
      0.051   13.5   0.1       0.06   13.3   0.1    1.3  1  TMEM154       TMEM154 protein family
      0.095   13.0   1.5       0.17   12.2   1.5    1.4  1  Sigma_reg_N   Sigma factor regulator N-terminal
      0.097   12.6   0.8       0.12   12.3   0.8    1.3  1  Tmemb_9       TMEM9
       0.13   12.2   3.2       0.23   11.5   3.2    1.3  1  OppC_N        N-terminal TM domain of oligopeptide transport 
       0.22   11.6  10.0       0.44   10.6  10.0    1.4  1  Insulin_TMD   Insulin receptor trans-membrane segment
        9.8    5.9   7.4       0.44   10.3   1.2    1.8  2  ASFV_J13L     African swine fever virus J13L protein


Domain annotation for each model (and alignments):
>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   9.6   1.3e-07   0.00023       2      29 .]      24      51 ..      23      51 .. 0.98

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 1.3e-07
  EGF_Tenascin  2 CPLGCssRGvCvDGqCiCDsEYsGDDCs 29
                  CP  Cs  G+C DG C C s + G DCs
    EFC35746.1 24 CPNHCSLNGICLDGVCQCLSGFLGSDCS 51
                  ***************************9 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8  10.7   4.3e-07   0.00078       1      32 []      24      50 ..      19      50 .. 0.94

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 4.3e-07
       EGF_2  1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                C+++   C+ +G+C    G+C+C sg+ G +C
  EFC35746.1 24 CPNH---CSLNGICL--DGVCQCLSGFLGSDC 50
                8877...*******9..9************** PP

>> ECSCR  Endothelial cell-specific chemotaxis regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.3   1.5e-05     0.028      27      94 ..      64     129 ..      46     136 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.5e-05
       ECSCR  27 visfivilvvvviilvsvvslrfkcrknkesedpqkpeisglsescstaigekdsitlismkninsnn 94 
                 + + i ++vv+viilv++  l +   k k+    ++  i  ++  + t +g kd i +    ni ++n
  EFC35746.1  64 IGAVISVVVVLVIILVAIFVLFYIGTKLKKGWGDKHRTIPSMVSIVPTLTG-KDEIPM-DHGNIVMDN 129
                 224566778889*********999999999888888888888877677666.666654.445555555 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.3       3.7   6.6e+03       1       3 [.      19      21 ..      12      26 .. 0.57
   2 ?   15.3   2.8   1.3e-05     0.023       1      22 []      28      45 ..      28      45 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3.7
                --T CS
        hEGF  1 Cnn 3 
                C n
  EFC35746.1 19 CAN 21
                334 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 1.3e-05
                --TT-EES..-SS.-EE--TTX CS
        hEGF  1 CnngGtCidgvggykCiCpPGy 22
                C+ +G+C    +g +C+C++G+
  EFC35746.1 28 CSLNGICL---DG-VCQCLSGF 45
                77789***...78.*******9 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   3.3e-05      0.06      51      90 ..      54      93 ..       9     111 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3.3e-05
     TMEM154 51 nesdqlelvlmiiiPlvllillllvviiliqkkkrkrsKd 90
                + + q + +++ ++ +v+++l++++v+i++  +  ++ K 
  EFC35746.1 54 DANAQFASIIIGAVISVVVVLVIILVAIFVLFYIGTKLKK 93
                5667788899999999*9999999****998888888775 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   1.5   9.4e-05      0.17       7      53 ..      57     106 ..      55     109 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 9.4e-05
  Sigma_reg_N   7 akrksilrivlislivlllifvilvvtllyl...aekegnklrevlelav 53 
                  a++ si+  ++is++v+l+i+++ ++ l y    ++k + + +++++++v
   EFC35746.1  57 AQFASIIIGAVISVVVVLVIILVAIFVLFYIgtkLKKGWGDKHRTIPSMV 106
                  78999999999***999999999999999997765555555566665555 PP

>> Tmemb_9  TMEM9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.8   6.6e-05      0.12       8      75 ..      12      85 ..       5     127 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.6e-05
     Tmemb_9  8 vsskkcncegvvlpklsdevkgkele.fcprC.......eCkyesRntttikvvviivivvislLviYmlflllld 75
                 +s+  +c++v  p+   +++g  l+ +c +C       +C+    n++   +++  vi+v+ +Lvi ++ + +l 
  EFC35746.1 12 CESNPASCANVTCPNHC-SLNGICLDgVC-QClsgflgsDCSVVDANAQFASIIIGAVISVVVVLVIILVAIFVLF 85
                55666677777777665.67776666333.3333344448999999999999999999999999999998877765 PP

>> OppC_N  N-terminal TM domain of oligopeptide transport permease C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   3.2   0.00013      0.23      16      35 ..      66      85 ..      65      94 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00013
      OppC_N 16 AvvglvilllllliaifaPl 35
                Av++ v++l+++l+aif  +
  EFC35746.1 66 AVISVVVVLVIILVAIFVLF 85
                9****************755 PP

>> Insulin_TMD  Insulin receptor trans-membrane segment
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6  10.0   0.00025      0.44      13      39 ..      58      85 ..      51      86 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00025
  Insulin_TMD 13 nivkIvigPviciillllvi.gavfvvv 39
                 + + I+ig vi ++++l++i +a+fv++
   EFC35746.1 58 QFASIIIGAVISVVVVLVIIlVAIFVLF 85
                 7899********9998877638999987 PP

>> ASFV_J13L  African swine fever virus J13L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.6       1.2   2.1e+03     137     154 ..       2      19 ..       1      31 [. 0.50
   2 ?   10.3   1.2   0.00024      0.44      18      52 ..      50      84 ..      40      95 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.2
   ASFV_J13L 137 asatasaaasdpaypael 154
                 asa+a aa +  + pa  
  EFC35746.1   2 ASANAVAADACESNPASC 19 
                 455554444444444432 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00024
   ASFV_J13L 18 lssvsapsffsthmytiliaivvliiiiivliylf 52
                 s v a + f++ +   +i++vv+++ii+v i+++
  EFC35746.1 50 CSVVDANAQFASIIIGAVISVVVVLVIILVAIFVL 84
                57788888888888888888888877777777643 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1598  (0.0891293); expected 358.6 (0.02)
Passed bias filter:                      820  (0.045736); expected 358.6 (0.02)
Passed Vit filter:                       151  (0.00842211); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 900.22
//
Query:       EFC35747.1  [L=391]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.7e-13   49.9   0.1    1.1e-12   48.4   0.0    1.8  2  Ank_2            Ankyrin repeats (3 copies)
    6.6e-10   38.4   0.1    0.00027   21.1   0.0    2.8  2  Ank_3            Ankyrin repeat
      2e-09   37.8   0.2    2.8e-05   24.6   0.0    2.5  3  Ank_4            Ankyrin repeats (many copies)
    9.6e-08   32.2   0.1     0.0088   16.5   0.0    2.7  2  Ank              Ankyrin repeat
    1.5e-07   31.5   0.0     0.0059   16.9   0.0    2.6  2  Ank_5            Ankyrin repeats (many copies)
     0.0072   16.9   6.0     0.0072   16.9   6.0    3.2  3  APG6_N           Apg6 coiled-coil region
  ------ inclusion threshold ------
      0.045   12.6   0.2      0.094   11.6   0.2    1.4  1  DUF1729          Domain of unknown function (DUF1729)
      0.055   13.9   2.5       0.13   12.7   0.1    2.7  3  Pullulanase_Ins  Pullulanase Ins domain
        1.7    9.1   4.2         30    5.1   1.0    2.6  2  DUF4062          Domain of unknown function (DUF4062)
        3.7    7.1  23.2      0.086   12.5   9.7    2.3  2  PTRF_SDPR        PTRF/SDPR family


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       8.9   1.6e+04      67      75 ..      51      59 ..      44      71 .. 0.57
   2 !   48.4   0.0     6e-16   1.1e-12      20      80 ..     220     282 ..     200     284 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 8.9
       Ank_2 67 eivklLlek 75
                e+++ Llek
  EFC35747.1 51 ETIEELLEK 59
                455555543 PP

  == domain 2  score: 48.4 bits;  conditional E-value: 6e-16
       Ank_2  20 adpnkngktaLhyAakngnleivklLleh..ad.ndgr..tpLhyAarsghleivklLlek.gadin 80 
                 +d+     t+L++A++ng+leivklLl+   +d n gr   pL+ A+++ghleivk Ll++ +++in
  EFC35747.1 220 VDF----DTPLYTACQNGYLEIVKLLLSCktIDvNLGRkfPPLYTACQNGHLEIVKQLLQHpNININ 282
                 343....4*******************96686665555337******************87566666 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0   2.4e-05     0.043       4      30 ..     224     250 ..     221     251 .. 0.87
   2 !   21.1   0.0   1.5e-07   0.00027       5      30 ..     257     282 ..     254     282 .. 0.95

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 2.4e-05
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 tpL++A+ +g leivk+Ll  k +dvn
  EFC35747.1 224 TPLYTACQNGYLEIVKLLLSCKTIDVN 250
                 9******************94477776 PP

  == domain 2  score: 21.1 bits;  conditional E-value: 1.5e-07
       Ank_3   5 pLhlAarsgnleivkfLlenkgadvn 30 
                 pL++A+ +g+leivk Ll+++++++n
  EFC35747.1 257 PLYTACQNGHLEIVKQLLQHPNININ 282
                 9**********************998 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0     2e-05     0.036      34      55 .]     221     242 ..     211     242 .. 0.89
   2 !   24.6   0.0   1.6e-08   2.8e-05       3      54 ..     224     273 ..     223     274 .. 0.90
   3 !   10.2   0.0    0.0005      0.89       4      30 ..     257     284 ..     255     291 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2e-05
       Ank_4  34 sGetalhiAakrgnveilklLl 55 
                 + +t+l+ A+++g++ei+klLl
  EFC35747.1 221 DFDTPLYTACQNGYLEIVKLLL 242
                 679******************8 PP

  == domain 2  score: 24.6 bits;  conditional E-value: 1.6e-08
       Ank_4   3 taLhyaaisgrlelvrlLl.ekgadinaqdnrsGetalhiAakrgnveilklL 54 
                 t+L  a++ g le+v+lLl +k +d+n    ++ +++l+ A+++g++ei+k L
  EFC35747.1 224 TPLYTACQNGYLEIVKLLLsCKTIDVNL---GRKFPPLYTACQNGHLEIVKQL 273
                 8999***************558899988...689****************966 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.0005
       Ank_4   4 aLhyaaisgrlelvrlLlek.gadinaq 30 
                 +L  a++ g+le+v+ Ll++ +++in++
  EFC35747.1 257 PLYTACQNGHLEIVKQLLQHpNININYT 284
                 5677888888888888888888888887 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   4.9e-06    0.0088       3      28 ..     223     250 ..     221     252 .. 0.83
   2 !   12.8   0.0   6.9e-05      0.12       5      29 ..     257     281 ..     255     284 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 4.9e-06
                 BBHHHHHHHHTTHHHHHHHH.TT.TSTT CS
         Ank   3 nTPLHlAatngkkriiklLL.hG.Anln 28 
                 +TPL  A++ng ++i+klLL +   ++n
  EFC35747.1 223 DTPLYTACQNGYLEIVKLLLsCKtIDVN 250
                 6*******************65345666 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 6.9e-05
                 HHHHHHHHTTHHHHHHHH.TTTSTTC CS
         Ank   5 PLHlAatngkkriiklLL.hGAnlna 29 
                 PL  A++ng+++i+k LL h  n+n+
  EFC35747.1 257 PLYTACQNGHLEIVKQLLqHP-NINI 281
                 9999**************663.6664 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   3.3e-06    0.0059       6      43 ..     214     245 ..     211     251 .. 0.83
   2 !   15.1   0.0   1.2e-05     0.021       1      38 [.     241     277 ..     241     284 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 3.3e-06
       Ank_5   6 padvnrldgggntpLhvAakygaadvvrlLlargadln 43 
                 ++dv + d +  tpL +A+ +g++++v+lLl    +++
  EFC35747.1 214 SEDVFDVDFD--TPLYTACQNGYLEIVKLLL----SCK 245
                 5788888888..*******************....554 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 1.2e-05
       Ank_5   1 LlehgpadvnrldgggntpLhvAakygaadvvrlLl.ar 38 
                 Ll++  +dvn  +++   pL +A+ +g++++v+ Ll  +
  EFC35747.1 241 LLSCKTIDVNLGRKF--PPLYTACQNGHLEIVKQLLqHP 277
                 7888999****9999..******************9433 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   6.0     4e-06    0.0072      11     127 ..       7     125 ..       5     131 .. 0.82
   2 ?   -0.6   0.6      0.99   1.8e+03      30      71 ..     156     209 ..     150     215 .. 0.54
   3 ?    2.1  10.6      0.14   2.6e+02      42      98 ..     302     360 ..     270     385 .. 0.66

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 4e-06
      APG6_N  11 leeldkqleqaekerdaYeeflkklkkekkeeek.qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreynel 108
                 l++++++le++e+++++  + l++l+ +++++ +   +++  l e +e+l ++ ++l +++++l k++ ++e+++++ +++++++ ++ ++  ++ + +
  EFC35747.1   7 LSTYTHELESVESKIEENITTLRRLNITNQSDPNfISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQSKTF 105
                 56789999999******9*****999765554337899***********************************************99999999999996 PP

      APG6_N 109 qlelleleeeldsl.eaqye 127
                   ++++  ++ +s  ++++e
  EFC35747.1 106 IETKAKGLNDGKSSnNSALE 125
                 66555555555544044455 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.99
      APG6_N  30 eflkklkkekkeeek............qdeeleeleeeleklekeeeelleeLk 71 
                 +f +kl++ k+++++            +d ++ +  +  ++l +e+++   e++
  EFC35747.1 156 TFANKLNEGKNSSNAieeddvvevkrnSDADVTNMYKGNANLTQEQRQRHDEIE 209
                 667777777666555655565555555444444444444555555554444443 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.14
      APG6_N  42 eek.qdeeleeleeeleklekeeeelleeLkelekereeleae.laaleeelealeeee 98 
                 e++  +e+ e+l+    ++e+ e+e +++L+    e+e++e+e l ++e+e ++le+++
  EFC35747.1 302 EQQlLKEQSEQLKFNQLEMERLERERIKKLEMERIEKERIEKEcLLKIERERKELEKKQ 360
                 11123444445555555566667777777777777777777763456666666666654 PP

>> DUF1729  Domain of unknown function (DUF1729)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.2   5.3e-05     0.094     119     177 ..      44     102 ..      33     117 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.3e-05
     DUF1729 119 svrSelgepihkianraaklwkeldetifsleavekrkaalekkrdeiierlnkdyakp 177
                 s  S l e i ++  ++ kl++++++   + ++ve+++   +kk++eii++l + y++ 
  EFC35747.1  44 SQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQS 102
                 67899*************************************************99754 PP

>> Pullulanase_Ins  Pullulanase Ins domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.1      0.95   1.7e+03      38      53 ..      48      63 ..      19      85 .. 0.65
   2 ?   -1.0   0.2       1.5   2.6e+03      35      35 ..      84      84 ..      51     136 .. 0.53
   3 ?   12.7   0.1   7.5e-05      0.13      15      36 ..     366     387 ..     357     389 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.95
  Pullulanase_Ins 38 sssktiaevleelkkd 53
                     + s+ti+e le+ +k 
       EFC35747.1 48 TLSETIEELLEKCRKL 63
                     4466777777776654 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.5
  Pullulanase_Ins 35 e 35
                      
       EFC35747.1 84 T 84
                     1 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 7.5e-05
  Pullulanase_Ins  15 dqpFskLCevnpavknseFaey 36 
                      ++ FskLC++n++v n + ++y
       EFC35747.1 366 SETFSKLCSLNQQVDNNRRKNY 387
                      579*************998887 PP

>> DUF4062  Domain of unknown function (DUF4062)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.1     0.028        50       3      45 ..      41      90 ..      41     107 .. 0.61
   2 ?    5.1   1.0     0.017        30       9      40 ..     297     339 ..     292     363 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.028
     DUF4062  3 FiSStfrdlkeeRealieallelglep.......vgmeefaardqsqlel 45
                FiSS ++ l+e  e+l+e++++l  +          +e+++++++++ + 
  EFC35747.1 41 FISSQISTLSETIEELLEKCRKLYNKInnltkndPSVENQVSDTKKKHKE 90
                99999999999999999999955443344433332223344444444444 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.017
     DUF4062   9 rdlkeeRealieallelglepvgmee...........faardq 40 
                 +d+++e + l+e+ ++l+++++ me+           +  +++
  EFC35747.1 297 SDMEKEQQLLKEQSEQLKFNQLEMERlererikklemERIEKE 339
                 79*******************9999855555554444444444 PP

>> PTRF_SDPR  PTRF/SDPR family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   9.7   4.8e-05     0.086       9     189 ..       2     197 ..       1     217 [. 0.74
   2 ?    0.5   5.6      0.22   3.9e+02     138     199 ..     299     359 ..     265     385 .. 0.55

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.8e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHXXXXXXX CS
   PTRF_SDPR   9 alLdkvvgivdsvqesqkrlEerqaelenavksiqgdllkLakshssTsntvnklleksrkvsvnvkevrerlekqavqvkklEaneaelLkrnkFkVl 107
                 + L+k+++   ++++  +++Ee  + l +   + q+d   ++ + s+ s+t++ llek rk  +++ ++ ++    ++qv    ++++e++ +   +  
  EFC35747.1   2 SSLEKLSTYTHELESVESKIEENITTLRRLNITNQSDPNFISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAK--LRAS 98 
                 679**************************9999*************************************998888999999999*****986..5666 PP

                 XXXXXXXXXXXX.XXXX......XXXXXXXXXXXXXX.XXXXXXXX.......................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
   PTRF_SDPR 108 iyqeenevpsklsvkksktpepeleeketeeeelekptidlssdee......................eveveeeaeesraerlkrsslkkvdslKkaF 184
                   q  + + +k+   ++ +++++++ ++t+  +l+  + + ss  +                      +++ ++ +ee     +kr+s   v ++ k  
  EFC35747.1  99 YKQSKTFIETKAKGLNDGKSSNNSALESTN-SNLT--SNSSSSATNsggasgggkkegfftfanklneGKNSSNAIEEDDVVEVKRNSDADVTNMYKGN 194
                 678888888888666652333222222222.2222..12222322256777777888888888887776667777777777888888888887777664 PP

                 XXXXX CS
   PTRF_SDPR 185 skenl 189
                 +  nl
  EFC35747.1 195 A--NL 197
                 4..44 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.22
                 XXXXXXX.XXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXX CS
   PTRF_SDPR 138 eeelekptidlssdeeeveveeeaeesraerlkrsslkkvdslKkaFske...nlektrqniekk 199
                  e++++   +  s++  +  + e+e+   er+k+  ++++++  +   ke    +e+ r+++ekk
  EFC35747.1 299 MEKEQQL-LKEQSEQL-KFNQLEMERLERERIKKLEMERIEK--ERIEKEcllKIERERKELEKK 359
                 2222211.22222222.2233334445556666666666653..222333111345555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2788  (0.155502); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.75u 0.37s 00:00:01.12 Elapsed: 00:00:00.56
# Mc/sec: 2111.69
//
Query:       EFC35748.1  [L=320]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.2e-06   26.3   1.3        1.2   10.1   0.1    4.0  4  WD40      WD domain, G-beta repeat


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.1   6.8e-05       1.2       5      37 ..     108     140 ..     104     141 .. 0.77
   2 ?    2.1   0.0     0.022     4e+02      14      32 ..     171     188 ..     162     192 .. 0.85
   3 !    9.7   0.0   9.4e-05       1.7      16      37 ..     220     242 ..     205     242 .. 0.85
   4 ?   -1.2   0.0      0.26   4.7e+03       9      18 ..     284     294 ..     277     314 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 6.8e-05
                 EEEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 + l+GH   +ts+++s  +  +a++s  g++ i+
  EFC35748.1 108 QLLDGHdETITSVKWSNLHGRIAACS-RGKIVIY 140
                 5689**666****8888888899999.6666665 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.022
                 EEEEEETTSSEEEEEETTS CS
        WD40  14 tslafspdgawlasGsdDg 32 
                  +++++ +g+ l+ G+ + 
  EFC35748.1 171 ECMDWNFYGDRLIVGG-KT 188
                 5999********9999.55 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 9.4e-05
                 EEEETTSSEEEEEET.TSEEEEE CS
        WD40  16 lafspdgawlasGsd.DgtvriW 37 
                 +a+spd +++a+ s+ D+ v++W
  EFC35748.1 220 VAYSPDEKYFATVSKfDRLVKVW 242
                 89*********99977******* PP

  == domain 4  score: -1.2 bits;  conditional E-value: 0.26
                 SS.SSEEEEEE CS
        WD40   9 GH.ssvtslaf 18 
                  H  svts+++
  EFC35748.1 284 PHpRSVTSISW 294
                 58667999954 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       491  (0.0273858); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1968.33
//
Query:       EFC35749.1  [L=468]
Description: hypothetical protein NAEGRDRAFT_54768 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1154  (0.064365); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2856.46
//
Query:       EFC35750.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-09   38.2   0.0    2.1e-09   37.4   0.0    1.3  1  ZT_dimer       Dimerisation domain of Zinc Transporter
    5.7e-09   36.0   3.8    8.2e-09   35.5   3.8    1.4  1  Cation_efflux  Cation efflux family


Domain annotation for each model (and alignments):
>> ZT_dimer  Dimerisation domain of Zinc Transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.4   0.0   2.3e-13   2.1e-09       3      77 ..     149     223 ..     147     224 .. 0.89

  Alignments for each domain:
  == domain 1  score: 37.4 bits;  conditional E-value: 2.3e-13
                 ..HHHHHHHHH.TT-SS-EEEEEEEEE-S----EEEEEEEE-TTS-HHHHHHHHHHHHHHHHHH-TT--EEEEEEE CS
    ZT_dimer   3 eeeeeeireii.ksvpgvkgvhdlrtrksGskifvdlhievdgdlsvkeaHeiadevekrikeefpgvadvliHve 77 
                 +e +++++ ++ ++ p +++v+++ + +sG +++v++++++++++++ ++H++ + ++k+i e++p+v+++++H++
  EFC35750.1 149 KEYIQKLTFMAlNHSPLITQVDSVMAYYSGANMIVEIDVVLPKETPLLDSHDVGESLQKKI-ESLPDVERCYVHLD 223
                 55566666666467999********************************************.599*********86 PP

>> Cation_efflux  Cation efflux family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.5   3.8   9.2e-13   8.2e-09     100     198 ..      52     142 ..       2     143 .. 0.91

  Alignments for each domain:
  == domain 1  score: 35.5 bits;  conditional E-value: 9.2e-13
  Cation_efflux 100 eihaglalvvalvslvvnlalllilrragrklrsaalkaaalhvlgDaltslgvlvsalvillfnlksgplaDpvaslligliilysalkllkesl 195
                    +i  ++ ++v+l+ ++++lal l +rr+    +s+++ a a+++++D+l++   lvs++++ +    +  ++D+++++l++ +i++s+ +   e +
     EFC35750.1  52 SIFYWYGIGVLLATILIKLALHLVCRRVK---HSPSVIAYAFDHRNDVLSNSLLLVSLFLSTYL---W--WLDSIGAVLLSTYIIKSWIQESLEHI 139
                    56678999*******************96...8**************************99997...4..9*****************99988887 PP

  Cation_efflux 196 seL 198
                      L
     EFC35750.1 140 TKL 142
                    776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       632  (0.0352502); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1569.76
//
Query:       EFC35751.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.42   10.6   7.7       0.95    9.6   7.7    1.6  1  AT_hook   AT hook motif
        1.5    7.3  21.4        1.7    7.1  21.4    1.1  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   7.7   0.00011      0.95       1      10 [.     213     222 .]     213     222 .] 0.95

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00011
     AT_hook   1 kRkRGRPrKa 10 
                 kR+RGRPrK+
  EFC35751.1 213 KRGRGRPRKN 222
                 8********7 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  21.4   0.00019       1.7     208     374 ..      42     218 ..      14     222 .] 0.50

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00019
    Macoilin 208 lldkeereaeeqlaaakelv....evd.pvalsknnhslnkk..dsslklpeleyrekk.ksakssrsdskkkhehnesvdsklqekeymenkskskrl 298
                   +++e+++   +++++e v    +v+ ++a  +++h+ ++   ++++ +  +  +ek+  s+ +  + s+++ +h  ++ +  q+++  +n s+++++
  EFC35751.1  42 QQEQQEQQGMLMQNTTNEHVegliCVEnTKASVQQQHAVAEPstSKTKPMMRIVLSEKNgISKCEIIETSQESMHHDVHKPHVSQHASTSTNFSHEHKI 140
                 222233333333334443333444777455555566665554223444455555555541455555555555666666777777788888888888888 PP

    Macoilin 299 sksessgsesellveesvkskssssssssnknskkasagsagssnsssk..khsessksvtsssssknskkqklpaGk 374
                  k ++ +s ++ +  + v+s ss+sssss+++s+++  ++ ++ n   +  k+s  +        +kn ++ k + G+
  EFC35751.1 141 IKPSKIKSRNNQNIMSRVRSVSSTSSSSSSSTSSSKIIEQNQTLNENENgiKLSVVTMDSYREEMTKNLNRPKRGRGR 218
                 887777777777777666666666655555444444333333333333300333333333333345555666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2464  (0.137431); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 1441.13
//
Query:       EFC35752.1  [L=285]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1049  (0.0585086); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.39u 0.21s 00:00:00.60 Elapsed: 00:00:00.36
# Mc/sec: 2401.48
//
Query:       EFC35753.1  [L=209]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.9e-08   32.3   4.8    2.7e-07   30.9   4.3    2.0  1  RGS          Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.012   15.2   2.2      0.012   15.2   2.2    2.1  2  SR-25        Nuclear RNA-splicing-associated protein
      0.054   13.5   1.6      0.071   13.1   0.7    1.6  1  PAPS_reduct  Phosphoadenosine phosphosulfate reductase family


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   4.3   4.5e-11   2.7e-07       7     116 ..       2     172 ..       1     174 [. 0.92

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 4.5e-11
                 TSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS........................................................SHHHHHHHH CS
         RGS   7 edqpgrslFreFlesefseenlsFwlaveefkka........................................................keqeelkkk 49 
                  d+++r+lFr+ +++e s +n  +++++ ++k                                                          + +++  + 
  EFC35753.1   2 RDNKLRKLFRDHCKQEMSLDNYLLLDKITDYKILceksfeiqvflyddmspnshsdslsdsgssatanssnldhqhkkkkkkgytekdlhEIEKKKYEI 100
                 5889****************************999***************************************************9885445555555 PP

                 HHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS  50 akeIyneylapsspkelnidkklreelekrleke......qpsrklfeeaqeevfellekdsypkFlkselyl 116
                 a+eIy  +l+ + +k++ni+k+  ++++++l         + + +lf+++++e++ l+  d +++F ++  ++
  EFC35753.1 101 AFEIYTDFLDINGDKSVNINKSAADRVKEQLDYFasgeneHLTDTLFDNVESEICVLML-DTHHRFKQTVEFQ 172
                 ******************************98777888889**************9995.7788999988776 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   2.2   2.1e-06     0.012      66     114 ..      52      96 ..      47     110 .. 0.46
   2 ?    1.9   1.4     0.024   1.4e+02     106     119 ..     173     186 ..     151     206 .. 0.46

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.1e-06
       SR-25  66 sssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekk 114
                   s+s s s s ss++++ss+ d+++++k k+k   +k  +     ekk
  EFC35753.1  52 PNSHSDSLSDSGSSATANSSNLDHQHKKK-KKKGYTEKDLH---EIEKK 96 
                 34444444444444444444443333332.22222222222...22222 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.024
       SR-25 106 kkkkkkekkkakek 119
                 k+ +k++ kk+k k
  EFC35753.1 173 KQTQKQHVKKNKVK 186
                 11122211111111 PP

>> PAPS_reduct  Phosphoadenosine phosphosulfate reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.7   1.2e-05     0.071      21      63 ..     149     191 ..     134     203 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.2e-05
                  HHCTTHEEEEEE-STB-HHHHHHHHHHHHHTT-EEEEEE-SCH CS
  PAPS_reduct  21 kafkpvpvvfvdtghefpetiefvdeleeryglrlkvyepeee 63 
                  ++  ++ v+ +dt h f++t+ef ++++++ + + kv  + ++
   EFC35753.1 149 NVESEICVLMLDTHHRFKQTVEFQKQTQKQHVKKNKVKFESNK 191
                  34445689*********************99444344443333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2419  (0.134921); expected 358.6 (0.02)
Passed bias filter:                      505  (0.0281667); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1325.45
//
Query:       EFC35754.1  [L=141]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1346  (0.0750739); expected 358.6 (0.02)
Passed bias filter:                      162  (0.00903564); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 937.00
//
Query:       EFC35755.1  [L=493]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.7e-39  134.2   0.2    5.2e-07   30.2   0.0    8.7  8  RCC1       Regulator of chromosome condensation (RCC1) repeat
    1.2e-32  111.0   9.3    1.8e-10   40.3   0.0    6.1  7  RCC1_2     Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.072   13.3   0.0         16    5.8   0.1    3.7  3  DUF4213    Putative heavy-metal chelation
       0.27   11.1   2.9        4.8    7.1   0.9    2.6  2  PKcGMP_CC  Coiled-coil N-terminus of cGMP-dependent protein k
       0.28   11.4   2.5        9.4    6.5   0.4    2.6  2  Sterile    Male sterility protein


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.0   5.5e-05       0.2       4      50 .]      14      63 ..      13      63 .. 0.71
   2 !   13.1   0.1   3.1e-05      0.11       1      21 [.      66      86 ..      66     102 .. 0.82
   3 ?    4.9   0.0     0.011        40      36      48 ..     166     178 ..     152     180 .. 0.74
   4 !   10.7   0.1   0.00018      0.66      32      49 ..     186     201 ..     179     202 .. 0.80
   5 !   14.0   0.0   1.6e-05     0.059       1      50 []     205     280 ..     205     280 .. 0.74
   6 !   17.3   0.0   1.6e-06    0.0056       1      50 []     283     340 ..     283     340 .. 0.77
   7 !   30.2   0.0   1.5e-10   5.2e-07       1      50 []     343     396 ..     343     396 .. 0.90
   8 !   20.0   0.0   2.3e-07   0.00082       5      31 ..     411     437 ..     409     450 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.5e-05
                EEEEE--GGGTTSSSS---E.......EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1  4 VysWGrndyGqLGlgttesv.......lvPtkveglsgnrvvkvacGddhtval 50
                ++s G n+++qL l ++ ++       ++P +     ++r++++++G  h+++l
  EFC35755.1 14 LFSSGYNEFYQLFLHDNINRnvltfsnTIPLQK----DERIKQISSGEKHSFLL 63
                7999**********9995551232222335333....33*************86 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 3.1e-05
                TTEEEEEE--GGGTTSSSS-- CS
        RCC1  1 dGrVysWGrndyGqLGlgtte 21
                +G++y+ G n++Gq G g+  
  EFC35755.1 66 KGKLYGIGMNEFGQVGVGNVS 86
                59***************9983 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.011
                 -EEEEEEETTEEE CS
        RCC1  36 rvvkvacGddhtv 48 
                  ++ v+cG d+t+
  EFC35755.1 166 FITNVVCGRDFTF 178
                 6889********9 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00018
                 GTTS-EEEEEEETTEEEE CS
        RCC1  32 lsgnrvvkvacGddhtva 49 
                 ++  +v ++acG++ht+ 
  EFC35755.1 186 PE--KVASIACGAFHTII 201
                 33..9***********87 PP

  == domain 5  score: 14.0 bits;  conditional E-value: 1.6e-05
                 TTEEEEEE--GGGTTSSSS-..--E...................EEEEE-GGGTTS.....-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt..esv...................lvPtkveglsgn.....rvvkvacGddhtval 50 
                 d ++y  G n +GqLG+ ++  e++                   ++P ++  ++        +++++ G+ h+++l
  EFC35755.1 205 DHHIYIMGLNIFGQLGIDPKvmEQRvknevyinpkgelidfsyiSKPIRLDYFDYMayegdFISHISTGACHSAFL 280
                 6789*************999884444556777777776666666669999555433555559999*****999986 PP

  == domain 6  score: 17.3 bits;  conditional E-value: 1.6e-06
                 TTEEEEEE--GGGTTSSSS---E.EEEEE-......GGGTTS...-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesv.lvPtkv......eglsgn...rvvkvacGddhtval 50 
                 +G+++ +G+n +G  G g++ +   +P+k       +    +    + +++cG dht+++
  EFC35755.1 283 SGKLFMCGFNINGEIGMGQSIRYsFTPKKPifrypyPYM--DespTIRAISCGLDHTIVV 340
                 59******************6664778776455544333..14469999********985 PP

  == domain 7  score: 30.2 bits;  conditional E-value: 1.5e-10
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS....-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgn....rvvkvacGddhtval 50 
                 +G+V+s G+n++GqLGlg+ +++     ve ++++    ++++v cG  h++++
  EFC35755.1 343 NGEVFSTGKNEDGQLGLGDVKNRYEFNMVEYFENEtlnsKIIDVECGMCHSIFI 396
                 69******************9997767788888778899************987 PP

  == domain 8  score: 20.0 bits;  conditional E-value: 2.3e-07
                 EEEE--GGGTTSSSS---EEEEEE-GG CS
        RCC1   5 ysWGrndyGqLGlgttesvlvPtkveg 31 
                 y  G+n yG LGlg+ e++ +Ptk+++
  EFC35755.1 411 YMSGCNKYGNLGLGDFENRKLPTKLTS 437
                 667*********************976 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.4   0.0   5.9e-10   2.1e-06       1      30 []      50      79 ..      50      79 .. 0.99
   2 ?   -0.5   0.0      0.32   1.1e+03       3      15 ..     169     181 ..     167     183 .. 0.78
   3 !   24.3   0.0   5.2e-09   1.9e-05       1      30 []     189     218 ..     189     218 .. 0.98
   4 !   18.6   0.5   3.3e-07    0.0012       2      26 ..     268     292 ..     267     296 .. 0.88
   5 !   40.3   0.0   5.1e-14   1.8e-10       1      30 []     327     356 ..     327     356 .. 0.97
   6 ?   -0.9   0.1      0.44   1.6e+03       1      14 [.     383     396 ..     383     397 .. 0.88
   7 ?   -3.9   0.0       3.7   1.3e+04      22      29 ..     412     419 ..     407     419 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.4 bits;  conditional E-value: 5.9e-10
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30
                +k++s+G  Hs+ Lt+ G++++ G N++GQ
  EFC35755.1 50 IKQISSGEKHSFLLTSKGKLYGIGMNEFGQ 79
                89***************************9 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.32
      RCC1_2   3 svsaGdyHscaLt 15 
                  v +G++++++ t
  EFC35755.1 169 NVVCGRDFTFIST 181
                 699*****98755 PP

  == domain 3  score: 24.3 bits;  conditional E-value: 5.2e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V+s+++G++H+++Lt+d +++  G N +GQ
  EFC35755.1 189 VASIACGAFHTIILTRDHHIYIMGLNIFGQ 218
                 89************************9999 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 3.3e-07
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsN 26 
                  ++s G++Hs +L+++G+++ +G N
  EFC35755.1 268 SHISTGACHSAFLSNSGKLFMCGFN 292
                 67*********************77 PP

  == domain 5  score: 40.3 bits;  conditional E-value: 5.1e-14
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++s+G +H++++te+GeV+++G N+dGQ
  EFC35755.1 327 IRAISCGLDHTIVVTENGEVFSTGKNEDGQ 356
                 689**************************9 PP

  == domain 6  score: -0.9 bits;  conditional E-value: 0.44
      RCC1_2   1 VksvsaGdyHscaL 14 
                 +++v +G +Hs+++
  EFC35755.1 383 IIDVECGMCHSIFI 396
                 799*******9875 PP

  == domain 7  score: -3.9 bits;  conditional E-value: 3.7
      RCC1_2  22 cWGsNsdG 29 
                   G+N +G
  EFC35755.1 412 MSGCNKYG 419
                 5699*998 PP

>> DUF4213  Putative heavy-metal chelation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.17     6e+02       9      38 ..      45      75 ..      39     114 .. 0.77
   2 ?    1.3   0.0      0.12   4.2e+02      13      31 ..     166     184 ..     154     232 .. 0.57
   3 ?    5.8   0.1    0.0044        16       8      32 ..     321     345 ..     318     405 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.17
     DUF4213  9 pedltVedvviGlnwtlVelsdg.gaGlAyt 38
                ++d +++++  G + +   +s+g   G+ ++
  EFC35755.1 45 QKDERIKQISSGEKHSFLLTSKGkLYGIGMN 75
                58999***********999999975677777 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.12
     DUF4213  13 tVedvviGlnwtlVelsdg 31 
                  +++vv+G  +t + +++ 
  EFC35755.1 166 FITNVVCGRDFTFISTDKE 184
                 5666666666666666552 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0044
     DUF4213   8 apedltVedvviGlnwtlVelsdgg 32 
                 ++e  t++ + +Gl  t+V++++g 
  EFC35755.1 321 MDESPTIRAISCGLDHTIVVTENGE 345
                 678899*****************63 PP

>> PKcGMP_CC  Coiled-coil N-terminus of cGMP-dependent protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.023        83       4      12 ..      44      52 ..      41      55 .. 0.83
   2 ?    7.1   0.9    0.0013       4.8       7      21 ..     151     165 ..     148     166 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.023
   PKcGMP_CC  4 llKDERIRE 12
                l KDERI+ 
  EFC35755.1 44 LQKDERIKQ 52
                57*****95 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0013
   PKcGMP_CC   7 DERIRELEkrlaekd 21 
                 ++ I+ELEk l+ kd
  EFC35755.1 151 EIQIKELEKELNYKD 165
                 789*********998 PP

>> Sterile  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.1     0.015        55      48      78 ..      82     113 ..      69     116 .. 0.87
   2 ?    6.5   0.4    0.0026       9.4      35      85 ..     119     173 ..     114     176 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.015
     Sterile  48 ndnlekLldrlsee.drkiFnfdvrsidwedY 78 
                 + n+++ l++l+++ d+k+++  +++i++++ 
  EFC35755.1  82 VGNVSSFLQNLNPQmDKKMYQQHMEKIEMSTH 113
                 6799999********************98776 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0026
     Sterile  35 lleyFtlnewkfdndnlekLldrlseedrkiFnfdv....rsidwedYfenyilG 85 
                 +l++ ++n+ +f+n+n +++ ++ ++  +k  ++++    ++++++d+++n++ G
  EFC35755.1 119 VLNPIINNNNNFNNNNNNNIKNENTKYGNKELEIQIkeleKELNYKDFITNVVCG 173
                 6888999*****************************6666669********9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (493 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1295  (0.0722293); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 3010.03
//
Query:       EFC35756.1  [L=373]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (373 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       740  (0.0412739); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2326.44
//
Query:       EFC35757.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.3e-05   22.1   2.3    0.00026   20.4   1.2    2.3  2  Terpene_synth_C  Terpene synthase family, metal binding domai


Domain annotation for each model (and alignments):
>> Terpene_synth_C  Terpene synthase family, metal binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   1.2   1.4e-08   0.00026      37     253 ..      49     260 ..      24     269 .. 0.80
   2 ?    0.1   0.0     0.024   4.2e+02     213     248 ..     261     295 ..     258     312 .. 0.80

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.4e-08
  Terpene_synth_C  37 faRdrlvecyfwalgvvfepeysraRiilaKvivlitilDDtyDvygtleEl..eklteaierWde.s.aveelpeymkilykallntfneled 126
                      + +  ++ c  +a+g + +  y+ +Ri +a ++  ++i+DD +D    ++E   ++l++ i+  ++ + + e ++       +  l +++el +
       EFC35757.1  49 YHKYGIADCCGCACGPFPQVSYKIMRI-FALITLYLSIVDDACDCLKDVDETirKELITHIQLVEKfEgQEEYFSRTHNPSIRLGLYVMDELFN 141
                      667778899999******999999986.67789999***********99996436788888777775424456666667777777888888888 PP

  Terpene_synth_C 127 elekeeksdrvskylkeawkelvkaylkeakWreekyvPsfeEylenslvssglpllllaalvgmgdevtk.eafewvasypklvkalstilRL 219
                      +++   +  ++ ++l+ ++ +++k+ l+ a+   ++   s+e   +   + s + + + +a + + d vt+ e        +k+ + +++++ L
       EFC35757.1 142 SCSFFTQF-QI-RTLQFEMVKYFKTSLEMATYWADGSQISVEKCDQWRRIDSLGSIYMEMAKLQF-DFVTTlE-------IEKFQRISNECFFL 225
                      88886666.67.699999***********998888877778888888888888888888875333.4455546.......99************ PP

  Terpene_synth_C 220 lnDiasyereqkrgdvassvecymkehg.vseeeA 253
                      +nD+as+ +e  +g +++   c  +e++ ++e++ 
       EFC35757.1 226 INDLASFPKELRDGTLVNHAICLQNETKqSTEQSF 260
                      *************9999999999999994555554 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.024
  Terpene_synth_C 213 lstilRLlnDiasyereqkrgdvassvecymkehgv 248
                      l+ti+RL + + + er ++  +v +s++  mk  gv
       EFC35757.1 261 LMTIARLYDFLMELER-METCQVRNSIKEAMKGFGV 295
                      5789999999999999.6666899999999998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.25s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 2359.40
//
Query:       EFC35758.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.3e-16   58.9   0.6    1.2e-15   58.2   0.6    1.3  1  Peptidase_C1  Papain family cysteine protease


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.2   0.6   6.9e-20   1.2e-15     124     195 ..       2      71 ..       1      78 [. 0.91

  Alignments for each domain:
  == domain 1  score: 58.2 bits;  conditional E-value: 6.9e-20
                   HHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEEEEEETTEEEEEEE-SBTTTSTBT CS
  Peptidase_C1 124 alkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivGygvengkkyWivkNsWgtdwgek 195
                   ++k+ ++++g v+  + a + df +Y+sG+y+ +  ++    hav+++G+g+e+g+ yWi  NsWg++wg +
    EFC35758.1   2 EIKRSIMNEGSVHTIMIALR-DFLTYESGIYTRN-SDTLVGIHAVQLIGWGKEKGESYWIGVNSWGETWGLN 71 
                   68999*********999999.6**********95.4445679****************************65 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       434  (0.0242066); expected 358.6 (0.02)
Passed bias filter:                      238  (0.0132746); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 2625.18
//
Query:       EFC35759.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-25   88.3   0.4    5.2e-19   68.1   0.1    2.0  2  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.1   0.1   2.9e-23   5.2e-19     114     174 ..       2      62 ..       1      67 [. 0.96
   2 !   19.9   0.0   1.3e-08   0.00023     214     278 ..      62     128 .]      58     128 .] 0.81

  Alignments for each domain:
  == domain 1  score: 68.1 bits;  conditional E-value: 2.9e-23
       Actin 114 lEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdl 174
                  +++fEkf vpaly+a+ avl+++asgkstg++v+sG+svt++vp+++G +L +ai ++++
  EFC35759.1   2 SQVMFEKFCVPALYVANRAVLALYASGKSTGMIVNSGDSVTHAVPIYEGHTLPHAILKMEM 62 
                 689*****************************************************99875 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 1.3e-08
       Actin 214 keelekltesyktleeeevleeiKesvcevsedpeg....deekss....sspeksYeLPDgseiklgeeRfk 278
                  + l++ ++ +++++e+e+  + Ke++c+ +  +++              +  +k Y +P g++++lg+eRf+
  EFC35759.1  62 MKMLTERGYTFTNTAEREI--DRKEKLCYLALYFQEemnsV----VreepTIDRKLYDIPKGNVVTLGNERFR 128
                 566788999*********9..679**********9654332....14454788888****************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       427  (0.0238162); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 757.24
//
Query:       EFC35760.1  [L=224]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      221  (0.0123264); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1502.59
//
Query:       EFC35761.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-19   68.2   5.2    0.00012   21.9   0.1    6.0  6  NHL       NHL repeat
    0.00026   20.7   0.2        9.5    5.7   0.0    3.5  3  SGL       SMP-30/Gluconolactonase/LRE-like region


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   4.9e-06     0.044       2      27 ..       5      29 ..       4      30 .. 0.82
   2 !   15.1   0.0     2e-06     0.018       1      27 [.      47      73 ..      47      74 .. 0.93
   3 !   10.1   0.1   7.6e-05      0.68       1      27 [.     103     129 ..     103     130 .. 0.88
   4 !    4.6   0.0    0.0042        38      12      27 ..     169     184 ..     159     185 .. 0.83
   5 ?   -2.1   0.1      0.54   4.9e+03      12      23 ..     224     235 ..     214     239 .. 0.68
   6 !   21.9   0.1   1.3e-08   0.00012       1      27 [.     270     296 ..     270     297 .. 0.96

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.9e-06
                SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  2 nyPhGvavdsnGdiyVaDsenhrvqv 27
                n+P+ v v sn+++++aD++n rv++
  EFC35761.1  5 NRPSAVFV-SNDEVFIADTGNDRVRK 29
                66666666.9*************987 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 2e-06
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +++P++++v+s++++y+++ e++ +++
  EFC35761.1 47 LYDPSSIVVSSSNQVYISEGERNLIFK 73
                689*******************99986 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 7.6e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P G+ +++n++++ +D +nhrv++
  EFC35761.1 103 LNSPCGLFITDNDEVLFCDKRNHRVRK 129
                 5677788899***************97 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.0042
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                  ++iy+aDs ++r+++
  EFC35761.1 169 KDEIYIADSFSNRIRK 184
                 589*****98888876 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 0.54
                 TTEEEEEECCCT CS
         NHL  12 nGdiyVaDsenh 23 
                 n++iy +D  nh
  EFC35761.1 224 NDEIYFSDLDNH 235
                 888888888888 PP

  == domain 6  score: 21.9 bits;  conditional E-value: 1.3e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P+G+ vds +++y aD +nh+v++
  EFC35761.1 270 LCWPTGIFVDSKNQVYFADHYNHCVRK 296
                 8************************97 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.9   0.0    0.0019        17     178     217 ..     100     136 ..      54     142 .. 0.66
   2 !    5.7   0.0    0.0011       9.5     146     217 ..     170     247 ..     167     258 .. 0.78
   3 !    5.4   0.0    0.0013        12     186     215 ..     273     302 ..     257     307 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0019
         SGL 178 dlkkgegepDGlavDaeGnvwvAvwgggkvvrfdpdGkli 217
                 ++k   + p Gl+++ +++v  +  ++++v+++d +G  i
  EFC35761.1 100 NTKL--NSPCGLFITDNDEVLFCDKRNHRVRKIDRNGI-I 136
                 2222..34888888888899999889999999888883.4 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0011
         SGL 146 ktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGkli 217
                 + +Y+aDs  ++i ++d +    ++       +++++ +      ++pD+l+v + ++++   ++++ ++++ p+G + 
  EFC35761.1 170 DEIYIADSFSNRIRKIDRNGIIHTIAGNGIEgYNGDRRNatdtslNNPDSLFVHN-DEIYFSDLDNHVIRKILPNGIIK 247
                 678**************988777776666545777777788888877******76.57888889999999999999544 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0013
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGk 215
                 p G++vD++++v+ A   +++v+++ ++G+
  EFC35761.1 273 PTGIFVDSKNQVYFADHYNHCVRKIFKNGN 302
                 779*********************999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       375  (0.0209158); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 2072.47
//
Query:       EFC35762.1  [L=301]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00045   19.2   0.8    0.00077   18.4   0.8    1.3  1  Fmp27_WPPW       RNA pol II promoter Fmp27 protein domain
     0.0042   16.4   2.3      0.007   15.6   2.3    1.3  1  TMPIT            TMPIT-like protein
     0.0088   15.4   2.2     0.0088   15.4   2.2    1.7  2  DUF3450          Protein of unknown function (DUF3450)
      0.009   15.7   0.5      0.009   15.7   0.5    1.9  2  DUF4988          Domain of unknown function
     0.0095   16.0   3.2     0.0096   16.0   1.5    1.8  2  Peptidase_S49_N  Peptidase family S49 N-terminal
  ------ inclusion threshold ------
      0.023   14.5   1.6       0.05   13.4   1.6    1.6  1  DivIC            Septum formation initiator
      0.025   13.7   3.0       0.04   13.0   3.0    1.3  1  Atg14            Vacuolar sorting 38 and autophagy-related su
      0.027   14.7   4.0      0.084   13.1   4.0    1.8  1  Seryl_tRNA_N     Seryl-tRNA synthetase N-terminal domain
      0.094   12.7   0.2       0.17   11.9   0.2    1.4  1  PilJ             Type IV pili methyl-accepting chemotaxis tra
       0.26   12.0   1.8       0.34   11.6   0.6    1.7  2  DUF2203          Uncharacterized conserved protein (DUF2203)
       0.69   10.3   8.4        1.9    8.8   8.4    1.7  1  YlqD             YlqD protein
        5.1    5.9  12.2       0.13   11.1   5.0    1.7  2  Spc7             Spc7 kinetochore protein


Domain annotation for each model (and alignments):
>> Fmp27_WPPW  RNA pol II promoter Fmp27 protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.8   5.2e-07   0.00077     166     236 ..      63     133 ..      52     179 .. 0.86

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 5.2e-07
  Fmp27_WPPW 166 ndpervqkelleeRleeleeqiekleekleelelksekedeelkeeieelekeikelkeklefletlledl 236
                  ++e+v+ + le+R+++l+eq +k + ++e+l+ k++++  ++++  ++ e++ +++++ ++++ ++++++
  EFC35762.1  63 SSSESVKITKLEKRIQQLNEQAKKYKATIEDLKRKRQEDALTIQSCKKQCERHDASMQQTKKLVLDFHNSI 133
                 46789999******************************988888888999999988888888887777665 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   2.3   4.7e-06     0.007       4      60 ..      70     126 ..      67     161 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 4.7e-06
       TMPIT   4 weelekefkeleetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksv 60 
                 +++lek++++l+e+ak+yk+++e+l++  ++ + +i+++kk++++ ++s++++kk v
  EFC35762.1  70 ITKLEKRIQQLNEQAKKYKATIEDLKRKRQEDALTIQSCKKQCERHDASMQQTKKLV 126
                 7899***********************************************999864 PP

>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   2.2   5.9e-06    0.0088      15      84 ..      67     136 ..      55     138 .. 0.87
   2 ?   -1.2   0.0      0.66   9.9e+02      85     112 ..     189     216 ..     186     220 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 5.9e-06
     DUF3450  15 aatldqalkeaekavaaaaqsqkkidklddekqellaeyralkeeleslevyneqlerlvasqeqeiasl 84 
                 + ++++++k  ++ +++a++  + i++l++++qe +  +++ k++ e+ ++  +q ++lv + +++i s+
  EFC35762.1  67 SVKITKLEKRIQQLNEQAKKYKATIEDLKRKRQEDALTIQSCKKQCERHDASMQQTKKLVLDFHNSILSM 136
                 55788999999999******************************************99999998888665 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.66
     DUF3450  85 eeqieeieeierelvpllekmidrLeqf 112
                 ++q   ++ i +++ pl+++   rL++f
  EFC35762.1 189 TQQFRALDLIMTRICPLMKESKHRLKNF 216
                 5788889999999*******99999988 PP

>> DUF4988  Domain of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.5     6e-06     0.009       4      90 ..      69     153 ..      67     173 .. 0.86
   2 ?   -1.0   0.1      0.78   1.2e+03     144     175 ..     228     257 ..     210     282 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 6e-06
     DUF4988   4 dvndlkdrvaaleeqvkelndniealkkll.eegkviteveensdgsyvltlsdgktitltqgkdgeakaPvigvdeegyWtvtlnge 90 
                 ++ +l++r++ l+eq+k+ +  ie lk+   e+  +i + +++ +   +  ++  k+++l   ++  +++ ++ v+e  yW++ ++g 
  EFC35762.1  69 KITKLEKRIQQLNEQAKKYKATIEDLKRKRqEDALTIQSCKKQCER-HDASMQQTKKLVLDFHNS-ILSMDIFEVKEGTYWIT-FEGV 153
                 6899***********************9994556788888887777.999************999.8999*****9999**98.5554 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.78
     DUF4988 144 Avgdkssedsffksvevdeeenlvvtlkdgee 175
                 Av+d++  ++  k v vde++n +v l+d+e+
  EFC35762.1 228 AVDDGT--TARAKVVLVDEDSNSTVLLQDAEQ 257
                 444444..444455555556666666666655 PP

>> Peptidase_S49_N  Peptidase family S49 N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   1.5   6.4e-06    0.0096      36     110 ..      63     136 ..      47     145 .. 0.82
   2 ?   -1.5   0.0       1.5   2.3e+03      66      76 ..     208     218 ..     173     250 .. 0.55

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 6.4e-06
  Peptidase_S49_N  36 kekgelevtkLneeykelkeeleealldeeelkaaekkekkeekeekkaekkkakeeeekkrvfvldFkGdikAs 110
                      ++++++++tkL+++ ++l+e+ ++   + e+lk+++++   + ++ kk+  ++++++ ++++  vldF+ +i   
       EFC35762.1  63 SSSESVKITKLEKRIQQLNEQAKKYKATIEDLKRKRQEDALTIQSCKKQC-ERHDASMQQTKKLVLDFHNSILSM 136
                      67899***********************9999999888888877777777.5555667777788*****998665 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.5
  Peptidase_S49_N  66 elkaaekkekk 76 
                      e k++ k+ k 
       EFC35762.1 208 ESKHRLKNFKD 218
                      22222222221 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   1.6   3.4e-05      0.05      21      55 ..      65     101 ..      54     124 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.4e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHCC-XX..XXX CS
       DivIC  21 qlkqeiaalqaelaklkaeneeLeaevkdLks..ded 55 
                 +   +i++l++ +++l+++ ++ +a ++dLk   +ed
  EFC35762.1  65 SESVKITKLEKRIQQLNEQAKKYKATIEDLKRkrQED 101
                 5566899***********************7555555 PP

>> Atg14  Vacuolar sorting 38 and autophagy-related subunit 14
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   3.0   2.7e-05      0.04      81     173 ..      68     152 ..      62     191 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.7e-05
       Atg14  81 erlqelkdklsqlkkeieekkkklaklsdklkkRrsdleslqneleerrkkqiaklqdaikrieqklsslssktlesrsslcselaklyglrr 173
                  ++ +l+++++ql+++ ++ k++++ l++k   R++d+        ++ kkq +++  +++++++   ++++++l++++++++e++ + +   
  EFC35762.1  68 VKITKLEKRIQQLNEQAKKYKATIEDLKRK---RQEDA-----LTIQSCKKQCERHDASMQQTKKLVLDFHNSILSMDIFEVKEGTYWITFEG 152
                 578899999999999999999999999988...77883.....33456778888899999999999999*********999999999887666 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   4.0   5.6e-05     0.084      29      81 ..      75     127 ..      65     139 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 5.6e-05
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHH CS
  Seryl_tRNA_N  29 delleldekrrelqveleelqaerNelskeIgkakkkkedaeeliaevkelke 81 
                   +++ +l+e+ ++ ++++e+l+++r e + +I+++kk+ e  ++ ++++k+l  
    EFC35762.1  75 KRIQQLNEQAKKYKATIEDLKRKRQEDALTIQSCKKQCERHDASMQQTKKLVL 127
                   57889999999999999999999999999999999999999999999998865 PP

>> PilJ  Type IV pili methyl-accepting chemotaxis transducer N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.2   0.00011      0.17      38      95 ..      71     126 ..      60     138 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
        PilJ  38 ydaaearaqlretiaqfdrtlaalrlgdpapgllvpaeavraqleaveqlWqelkkpa 95 
                 ++ +++ +ql+e+++ + +t++ l+++ +++ l     + ++q e+ ++ +q+ kk +
  EFC35762.1  71 TKLEKRIQQLNEQAKKYKATIEDLKRKRQEDALTIQ--SCKKQCERHDASMQQTKKLV 126
                 4668899***********************766665..9***************9987 PP

>> DUF2203  Uncharacterized conserved protein (DUF2203)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.6   0.00023      0.34      28      89 ..      69     132 ..      56     139 .. 0.79
   2 ?   -1.9   0.0       3.5   5.3e+03      27      45 ..     207     225 ..     190     267 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00023
     DUF2203  28 eleeleeeleeakaeaekse..aaeleaeleeleaeieelveeieelGvevkdleaglvDFpak 89 
                 ++++le+++++ +++a+k +   + l+++ +e +  i++  ++ e++ + +++ +++++DF+ +
  EFC35762.1  69 KITKLEKRIQQLNEQAKKYKatIEDLKRKRQEDALTIQSCKKQCERHDASMQQTKKLVLDFHNS 132
                 56666666666666665555558889999999999999***********************865 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 3.5
     DUF2203  27 keleeleeeleeakaeaek 45 
                 ke +++ ++ ++ k++  +
  EFC35762.1 207 KESKHRLKNFKDRKSKLFN 225
                 3333333333333333332 PP

>> YlqD  YlqD protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   8.4    0.0013       1.9      28      89 ..      69     136 ..      64     157 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0013
        YlqD  28 qieqldkelqqLefqakrlikeikkqsaq......qieeiqeqvekekserlekkkqllqqleqvqkL 89 
                 +i++l+k +qqL+ qak+  + i+  + +      +i++ ++q e+  + ++++kk +l+  + + ++
  EFC35762.1  69 KITKLEKRIQQLNEQAKKYKATIEDLKRKrqedalTIQSCKKQCERHDASMQQTKKLVLDFHNSILSM 136
                 78999************998888775555556777888888888888888888887777665555444 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   5.0   8.8e-05      0.13     197     255 ..      66     124 ..      61     145 .. 0.56
   2 ?   -1.3   0.7      0.51   7.6e+02     230     306 ..     207     283 ..     205     287 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 8.8e-05
        Spc7 197 dkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeaer 255
                 ++ ++ +l +++++l+++ ++ k+ +++l+++++e + +i++ k+q++++ + +++ ++
  EFC35762.1  66 ESVKITKLEKRIQQLNEQAKKYKATIEDLKRKRQEDALTIQSCKKQCERHDASMQQTKK 124
                 34445555555555555555555555555555555555555555555555555555554 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.51
        Spc7 230 eeleekieelkeqkseleeeiaeaervleeckgwsesevsrlkeevkaleeltgwkivslsgstleltyrselevsf 306
                 +e++ ++++ k++ks+l ++ a  + ++ + k +  +e s+ +  +++ e+ t+++  ++ ++  ++ +++++e++ 
  EFC35762.1 207 KESKHRLKNFKDRKSKLFNRKAVDDGTTARAKVVLVDEDSNSTVLLQDAEQNTDISTDGIVNNNNNMNIDNNIELNE 283
                 67778888888888888888888888888888888888888888889999999999999999999999999998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2313  (0.129009); expected 358.6 (0.02)
Passed bias filter:                      917  (0.0511462); expected 358.6 (0.02)
Passed Vit filter:                       168  (0.00937029); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.73u 0.38s 00:00:01.10 Elapsed: 00:00:00.58
# Mc/sec: 1558.36
//
Query:       EFC35763.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.19   11.0   0.0       0.49    9.7   0.0    1.6  2  Pec_lyase  Pectic acid lyase


Domain annotation for each model (and alignments):
>> Pec_lyase  Pectic acid lyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0   2.8e-05      0.49      12      75 ..       3      67 ..       1      75 [. 0.88
   2 ?   -1.3   0.0     0.061   1.1e+03     124     143 ..      82     101 ..      68     105 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 2.8e-05
   Pec_lyase 12 dykseltekeakkvlkekkkeegtiDndatvtell.flaevykatkdekykdavrkglefllkaq 75
                +yk +++++ +++vl++kk++ + +D    v  ll +l ev+ +++ eky +  +  + fll+a 
  EFC35763.1  3 KYKVTIKPQSSSDVLEKKKEVLSLLDKPEQVDSLLaLLDEVFSNSNVEKYSAISKDDFAFLLEAR 67
                688899999999**************99888876516789**********************986 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.061
   Pec_lyase 124 ksqrkrlkkavekGidciLk 143
                 +++r  + ka++ G +c+++
  EFC35763.1  82 EEKRLAILKALNSGQECVIN 101
                 33444466999999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       534  (0.0297841); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1143.87
//
Query:       EFC35764.1  [L=389]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00015   21.6   0.1    0.00035   20.4   0.0    1.7  2  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.066   12.8   0.2       0.38   10.3   0.1    2.3  2  F-box_5     F-box


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   3.9e-08   0.00035       2      47 ..      97     145 ..      96     146 .. 0.89
   2 ?   -2.8   0.0      0.69   6.2e+03      38      47 ..     243     252 ..     240     253 .. 0.73

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 3.9e-08
  F-box-like   2 srLPdE.iLlqIFsyLppsdLlrla..lVCrrWrrvaldtplLWrrlvl 47 
                  +LP+E +   I  ++++++ l+++  lVCr+W++   d+ ++W++l++
  EFC35764.1  97 KSLPPEvVAYSIVPFMDLESVLNGSvfLVCRSWYEGMIDEERMWQELFC 145
                 68****6667899999*******9999********999999****9987 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.69
  F-box-like  38 tplLWrrlvl 47 
                  p+L++r  +
  EFC35764.1 243 APSLYSRFHI 252
                 469**99876 PP

>> F-box_5  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.18   1.6e+03       6      19 ..      40      53 ..      36      54 .. 0.83
   2 ?   10.3   0.1   4.3e-05      0.38      24      34 ..     121     131 ..     120     133 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.18
                GGTHHHHHCC---H CS
     F-box_5  6 DeVlecVlpyitsp 19
                ++V e+ l++++s 
  EFC35764.1 40 EQVDEHMLKFVEST 53
                67889******985 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 4.3e-05
                 HHTTS-HHHHH CS
     F-box_5  24 AvSlVCkrWYe 34 
                 +v lVC++WYe
  EFC35764.1 121 SVFLVCRSWYE 131
                 6779******7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1471  (0.0820458); expected 358.6 (0.02)
Passed bias filter:                      574  (0.0320152); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.40
# Mc/sec: 2882.94
//
Query:       EFC35765.1  [L=333]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.3e-29  101.2   0.2    7.3e-29  100.5   0.2    1.3  1  Ras          Ras family
    4.8e-11   42.9   0.0    9.1e-11   42.0   0.0    1.5  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    1.5e-09   37.5   0.0    2.9e-09   36.6   0.0    1.3  1  Arf          ADP-ribosylation factor family
    5.8e-09   35.8   0.1    1.1e-08   34.8   0.1    1.4  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    2.9e-06   27.3   0.2    0.00069   19.6   0.2    2.3  2  RsgA_GTPase  RsgA GTPase
    0.00013   22.0   0.0    0.00026   21.1   0.0    1.5  1  MMR_HSR1     50S ribosome-binding GTPase
     0.0057   16.5   0.3      0.027   14.3   0.1    2.0  2  ATP_bind_1   Conserved hypothetical ATP binding protein
     0.0088   15.4   1.0      0.024   14.0   1.0    1.7  1  Gtr1_RagA    Gtr1/RagA G protein conserved region
  ------ inclusion threshold ------
      0.018   14.3   2.9        1.5    7.9   0.1    2.8  3  G-alpha      G-protein alpha subunit
       0.12   11.8   0.5        4.6    6.6   0.0    2.2  2  ParA         NUBPL iron-transfer P-loop NTPase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.5   0.2     4e-32   7.3e-29       1     159 [.     127     293 ..     127     295 .. 0.89

  Alignments for each domain:
  == domain 1  score: 100.5 bits;  conditional E-value: 4e-32
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++++G+++vGK+++++ f+++ F +ey++Ti +d y+k ++vd++ + +ei+DTAG eef+   ++y+r ++++++v + ++++s +++++ ve++ r
  EFC35765.1 127 KIIVLGEGGVGKSAITIFFIQHIFITEYDPTI-EDTYRKYFRVDEEPAMVEILDTAGPEEFS---NQYMRVGDAFVIVCSSSDENSVSDMRRHVENMLR 221
                 89******************************.***************************97...69******************************** PP

                 HST...TTSEEEEEEETTTGGG....G-SS-..HHHHHHHHHHHT.SEE..EEEBTTTTCTHHHHHHHHHHH CS
         Ras 100 vae...envpivLvGnKvDlee....kravs..teegeelakelg.lkf..letSAktnenveeafeellre 159
                  ++   +++p+v v nK+Dl      +++++  ++e++++ ++++ l++  +e+SAk+ en++ +fee +r+
  EFC35765.1 222 CKDvevNDMPVVFVLNKMDLLVstnrNETIDrfRQEVNSIVSDNSlLNYsiIECSAKNGENIDAIFEETVRK 293
                 99999999***********977677755565223666666666665555448****************9987 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.0   0.0     5e-14   9.1e-11       1     120 []     127     241 ..     127     241 .. 0.74

  Alignments for each domain:
  == domain 1  score: 42.0 bits;  conditional E-value: 5e-14
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHHHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssenlkeWl 99 
                 K++++G++gvGK+ +   f+++ f +++++ti  ++  k + ++++       +   ++i DtaG e+f++    y+r  +++++v+ s++++++++  
  EFC35765.1 127 KIIVLGEGGVGKSAITIFFIQHIFITEYDPTIEDTYR-KYF-RVDE-------EPAMVEILDTAGPEEFSN---QYMRVGDAFVIVCSSSDENSVSDMR 213
                 9*******************************98875.444.3433.......34679***********86...6999999999998755554443333 PP

                 HHHHHH.......CSSS-EEEEEE-TTT CS
         Roc 100 kelkkv.......agkspvilvgnkiDl 120
                 ++++++       +++ pv++v nk+Dl
  EFC35765.1 214 RHVENMlrckdveVNDMPVVFVLNKMDL 241
                 333332111121245679********95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6   0.0   1.6e-12   2.9e-09      10     169 ..     121     288 ..     116     293 .. 0.81

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 1.6e-12
                 T.TTEEEEEEEESTTSSHHHHHHHHHHSSC.EECSSSSSEEEEE...EEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHH CS
         Arf  10 lkkkelrilllGLDnaGKtTilkklkleel.vttvPTigfnvee...leiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeL 104
                 +++ e++i++lG  + GK+ i   + ++ + ++  PTi  + ++   +  +   +++ D  G e+     ++Y++  da + v  s+d++ ++++++ +
  EFC35765.1 121 QQQEEVKIIVLGEGGVGKSAITIFFIQHIFiTEYDPTIEDTYRKyfrVDEEPAMVEILDTAGPEEF---SNQYMRVGDAFVIVCSSSDENSVSDMRRHV 216
                 4589****************987776666515689***999876333677889999*****99975...679*************************** PP

                 HHHCTSGCCT..TSEEEEEEE-TTSTTSS-HHHHHHHTTGGG..SS...SSSSEEEEEEBTTTTBTHHHHHH CS
         Arf 105 kalleeeelk..evallvlaNKqDlpealseeelrellglee..lk...gkrkleiqkcsavkgeglkegle 169
                 +++l+ ++++  +++++ + NK+Dl  + +++e  +    e   +    +  + +i++csa +ge+++  +e
  EFC35765.1 217 ENMLRCKDVEvnDMPVVFVLNKMDLLVSTNRNETIDRFRQEVnsIVsdnSLLNYSIIECSAKNGENIDAIFE 288
                 ****977654449************999999887665543322455344455789**********9988776 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.8   0.1   6.2e-12   1.1e-08      55     190 ..     157     292 ..     152     295 .. 0.78

  Alignments for each domain:
  == domain 1  score: 34.8 bits;  conditional E-value: 6.2e-12
                 CSSCEEEEEET.TCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB....STHHHHHHHHHHHHTTTE...EEEEEESCGST.HHHHHHHHH CS
    GTP_EFTU  55 Tiksaaislek.etkkylinliDtPGHvdFskevirglrvlDgavlvvdaveG....vepqteevlrlalkegvp...iivfiNKmDrl.kaelkeive 144
                 Ti+ +  ++++ +++   + ++Dt G ++Fs++    +rv D  v+v+++++      + +  e++  +++++v+   +++++NKmD l  ++ +e+++
  EFC35765.1 157 TIEDTYRKYFRvDEEPAMVEILDTAGPEEFSNQY---MRVGDAFVIVCSSSDEnsvsDMRRHVENMLRCKDVEVNdmpVVFVLNKMDLLvSTNRNETID 252
                 677777777766889999*************987...6789999999999987666545555566666677777677689999*****99888889999 PP

                 HHHHHHHHHHHHHHHHHHTTT.TTEEEEEEBTTTTBTHHHHHHHHHH CS
    GTP_EFTU 145 evkqklsrkeeklekygekge.kevpvvfgSalkgegvktllealve 190
                   +q++       ++++ +++  +++++ +Sa++ge++++++e  v+
  EFC35765.1 253 RFRQEV-------NSIVSDNSlLNYSIIECSAKNGENIDAIFEETVR 292
                 999888.......2222222225689**************9998765 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0    0.0086        15     101     116 ..     127     142 ..      94     152 .. 0.83
   2 !   19.6   0.2   3.8e-07   0.00069      17      96 ..     195     289 ..     184     296 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0086
                  EEEEECSTTSSHHHHH CS
  RsgA_GTPase 101 tsvlvGqSGvGKStLi 116
                   ++++G+ GvGKS++ 
   EFC35765.1 127 KIIVLGEGGVGKSAIT 142
                  46789********975 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 3.8e-07
                  -EEEEEEESTTTT-.-..HHHHHHHHHH..HHHTT-EEEEEEE-GGG--HHH..........HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHH CS
  RsgA_GTPase  17 dqllivvslkepel.s..lnlldrfLvl..aeekgiepvivlnKiDlleeee..........eleelkeelealgyevllvsaktkegleelkel 96 
                  d  +iv+s ++++  s   + ++ +L    +e +++++v vlnK+Dll +++          e++++ ++ + l+y+++ +sak++e+++++ e+
   EFC35765.1 195 DAFVIVCSSSDENSvSdmRRHVENMLRCkdVEVNDMPVVFVLNKMDLLVSTNrnetidrfrqEVNSIVSDNSLLNYSIIECSAKNGENIDAIFEE 289
                  566777776644331211345677775333788999***********9888888999999999999999999******************99765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   1.4e-07   0.00026       1     114 []     127     238 ..     127     238 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 1.4e-07
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSE.EEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.TTCSHHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdi.negrvklkgkeielvDtpGliegaseekglgkaflaleeadlillvvdas.eeklkpldeel 97 
                 +++++G   vGKS +    ++   i++  p    +  +++rv+++   +e++Dt+G  e      ++++++ ++ +  ++++v+++s e++++++++++
  EFC35765.1 127 KIIVLGEGGVGKSAITIFFIQHIFITEYDPTIEDTYrKYFRVDEEPAMVEILDTAG-PE------EFSNQYMRVGD--AFVIVCSSSdENSVSDMRRHV 216
                 5899****************9988887666444443478889877799********.88......89999998776..555555544456799999999 PP

                 HHHHHH.....TTSEEEEEEES CS
    MMR_HSR1  98 eellee.....akkplilvlnk 114
                 e++l+      ++ p+++vlnk
  EFC35765.1 217 ENMLRCkdvevNDMPVVFVLNK 238
                 999866788889999999*998 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.44   7.9e+02       1      20 [.     130     149 ..     130     158 .. 0.81
   2 !   14.3   0.1   1.5e-05     0.027     127     210 ..     201     289 ..     178     304 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.44
  ATP_bind_1   1 vvGpaGsGKttfvgalseil 20 
                 v+G  G+GK+ ++  +++++
  EFC35765.1 130 VLGEGGVGKSAITIFFIQHI 149
                 8999******9998888876 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1.5e-05
  ATP_bind_1 127 vyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek.lekeleffedvealslllekee.......ekykklaeaiaellee 210
                     D + ++d    +++ ++ ++ +   ++P v vlnk+Dll +  +++ +++f   ++++ +  +++       e  +k+ e+i +++ee
  EFC35765.1 201 CSSSDENSVSDMRRHVEN-MLRCKDVEVNDMPVVFVLNKMDLLVSTnRNETIDRFR--QEVNSIVSDNSllnysiiECSAKNGENIDAIFEE 289
                 445688889999999999.55566666679************99777777777776..2333333222233355555555555555555555 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   1.0   1.3e-05     0.024       1     149 [.     127     267 ..     127     289 .. 0.66

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.3e-05
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidve.ksevrf.lgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedlet 97 
                 k++ +G++g GK+++     + +  ++      ti+ + ++ +r+  +  +++++D  G e+f ++y+        r  ++ + V  +++++  +d+++
  EFC35765.1 127 KIIVLGEGGVGKSAITIFFIQHIFITEY---DPTIEDTyRKYFRVdEEPAMVEILDTAGPEEFSNQYM--------RVGDAFVIVCSSSDENSVSDMRR 214
                 6888899999998887544444444443...3444333033344414456889999999999999883........33346666777776765555555 PP

   Gtr1_RagA  98 lkeilealrqys.peakvfvlihKmDliqedereeifeerkeeireeieklek 149
                  +e + + ++++ +++ v   ++KmDl+ + +r+e++++ ++e+++ +++ + 
  EFC35765.1 215 HVENMLRCKDVEvNDMPVVFVLNKMDLLVSTNRNETIDRFRQEVNSIVSDNSL 267
                 5555555555441667777778*********************9998887554 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.75   1.3e+03     277     297 ..      42      63 ..      26     113 .. 0.69
   2 ?    5.9   0.0    0.0035       6.3      20      39 ..     122     141 ..     111     167 .. 0.80
   3 ?    7.9   0.1   0.00081       1.5     262     294 ..     222     254 ..     195     295 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.75
                 E-HHHHHHHCCCS.-GGGCCTT CS
     G-alpha 277 nKlDileeKlkkg.klskyfps 297
                  K+   ++K++++ ++++yf  
  EFC35765.1  42 AKFQSINKKISNMkEMQDYFNA 63 
                 4555555666555566666544 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0035
                 E..EEEEEEEESTTSSHHHH CS
     G-alpha  20 kkrevkllllGqseSGKsTi 39 
                 +++evk+++lG+++ GKs i
  EFC35765.1 122 QQEEVKIIVLGEGGVGKSAI 141
                 3679**************87 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.00081
                 CC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGGC CS
     G-alpha 262 cnnkllkntpiiLflnKlDileeKlkkgklsky 294
                 c+  +++++p++++lnK+D+l +  +++ + ++
  EFC35765.1 222 CKDVEVNDMPVVFVLNKMDLLVSTNRNETIDRF 254
                 4445568**************887776655554 PP

>> ParA  NUBPL iron-transfer P-loop NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.0    0.0026       4.6       5      22 ..     126     143 ..     122     154 .. 0.84
   2 ?    3.2   0.2     0.028        49     139     197 ..     198     262 ..     187     294 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0026
        ParA   5 viavlSgKGGVGKStvav 22 
                 v +++ g GGVGKS +++
  EFC35765.1 126 VKIIVLGEGGVGKSAITI 143
                 456778*********996 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.028
        ParA 139 aviVttpqevaladvkkaie.m..fkkv...kvkvlGvveNmsgfvcpkcgekteifgkgggekl 197
                 ++++++  e +++d ++++e m  +k+v   +++v+ v++ m  +v ++ +e+++ f+++  + +
  EFC35765.1 198 VIVCSSSDENSVSDMRRHVEnMlrCKDVevnDMPVVFVLNKMDLLVSTNRNETIDRFRQEVNSIV 262
                 56778889999999999986352234441115688999999************999988755544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1034  (0.0576719); expected 358.6 (0.02)
Passed bias filter:                      572  (0.0319036); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 2074.59
//
Query:       EFC35766.1  [L=246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1012  (0.0564449); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1601.38
//
Query:       EFC35767.1  [L=468]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-22   79.6  91.6    1.5e-06   28.4   9.0    7.8  7  EGF_2     EGF-like domain
    2.6e-07   30.8  63.7    0.00084   19.6   2.2    8.0  7  EGF       EGF-like domain
  ------ inclusion threshold ------
        2.5    8.2   4.7        4.8    7.2   4.7    1.4  1  OppC_N    N-terminal TM domain of oligopeptide transport perm
        5.1    6.9   7.4         31    4.4   0.0    4.5  7  DUF346    Repeat of unknown function (DUF346)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   6.1   1.7e-07   0.00077       5      32 .]      20      46 ..      17      46 .. 0.91
   2 !   28.4   9.0   3.4e-10   1.5e-06       1      32 []      63      93 ..      63      93 .. 0.92
   3 !   15.7   4.7   3.2e-06     0.014       7      32 .]     108     132 ..     103     132 .. 0.94
   4 !   10.7   6.0   0.00012      0.52       7      32 .]     147     170 ..     143     170 .. 0.79
   5 !   15.4   5.0     4e-06     0.018       6      32 .]     184     209 ..     180     209 .. 0.89
   6 !   14.8   4.8     6e-06     0.027       5      32 .]     226     252 ..     222     252 .. 0.88
   7 !   11.8   8.3   5.2e-05      0.23       5      32 .]     265     291 ..     257     291 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 1.7e-07
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyqGktC 32
                ++ C+  G+Cv ++ qC+C sg+ Gk C
  EFC35767.1 20 SNVCNSLGVCVGPN-QCKCLSGWGGKLC 46
                689********888.************9 PP

  == domain 2  score: 28.4 bits;  conditional E-value: 3.4e-10
       EGF_2  1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                C a +++C+g+G+C++++ +C+C+ g++G+ C
  EFC35767.1 63 CIAKSNACSGNGKCIDLN-RCKCEKGWTGPLC 93
                6667899*******9999.************9 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 3.2e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g G+Cv++  +C C + + G  C
  EFC35767.1 108 VCNGFGVCVAPD-KCNCYRDWGGEFC 132
                 6********999.***********99 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00012
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ +G+C++   +C+C+s + Gk C
  EFC35767.1 147 VCNSRGICIEND-ECRCNS-WGGKLC 170
                 6*******9555.8***85.777777 PP

  == domain 5  score: 15.4 bits;  conditional E-value: 4e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+  G+Cv++  +C+C+sgy  + C
  EFC35767.1 184 NVCNSSGVCVDFD-KCECFSGYGDAFC 209
                 67********9*9.********77777 PP

  == domain 6  score: 14.8 bits;  conditional E-value: 6e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g+G C  ++ +C C++++ G  C
  EFC35767.1 226 GAVCSGRGLCLGPN-KCICQPNWGGFMC 252
                 568********888.********99877 PP

  == domain 7  score: 11.8 bits;  conditional E-value: 5.2e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +e C+ghG C++    C+C +gy   +C
  EFC35767.1 265 KEVCSGHGDCIAVD-TCKCYQGYMDYDC 291
                 789*******9667.8*******87776 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   2.1   0.00027       1.2       3      31 ..      20      44 ..      18      45 .. 0.80
   2 !   19.6   2.2   1.9e-07   0.00084       3      31 ..      67      91 ..      65      92 .. 0.91
   3 !    5.7   1.4    0.0042        19       5      31 ..     107     130 ..     102     131 .. 0.84
   4 !    5.6   3.5    0.0043        19       4      24 ..     144     162 ..     142     164 .. 0.85
   5 !   11.3   1.6   7.6e-05      0.34       3      29 ..     183     205 ..     180     208 .. 0.86
   6 !    4.7   3.5    0.0088        39       6      30 ..     229     249 ..     223     249 .. 0.85
   7 !    8.8   3.8   0.00045         2       5      28 ..     266     286 ..     257     288 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00027
                STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF  3 pnpCsngGtCvdtgrggytCiCpeGytGk 31
                +n C+  G Cv +     +C+C +G+ Gk
  EFC35767.1 20 SNVCNSLGVCVGP----NQCKCLSGWGGK 44
                466*******433....47********98 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 1.9e-07
                STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF  3 pnpCsngGtCvdtgrggytCiCpeGytGk 31
                +n Cs++G+C+d+     +C+C  G+tG+
  EFC35767.1 67 SNACSGNGKCIDLN----RCKCEKGWTGP 91
                466***********....**********7 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0042
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + C++ G Cv +     +C C   + G+
  EFC35767.1 107 TvCNGFGVCVAPD----KCNCYRDWGGE 130
                 55***********....****8877776 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.0043
                 TT..STTT-EEEEETTTEEEEEE CS
         EGF   4 np..CsngGtCvdtgrggytCiC 24 
                 +p  C+ +G+C+++     +C+C
  EFC35767.1 144 DPtvCNSRGICIEND----ECRC 162
                 5667*******9999....9999 PP

  == domain 5  score: 11.3 bits;  conditional E-value: 7.6e-05
                 STTSTTT-EEEEETTTEEEEEECTTEE CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGyt 29 
                 pn C+  G Cvd      +C+C +Gy 
  EFC35767.1 183 PNVCNSSGVCVDFD----KCECFSGYG 205
                 455***********....*******96 PP

  == domain 6  score: 4.7 bits;  conditional E-value: 0.0088
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 Cs++G C     g  +CiC++ + G
  EFC35767.1 229 CSGRGLC----LGPNKCICQPNWGG 249
                 *******....57779*****9987 PP

  == domain 7  score: 8.8 bits;  conditional E-value: 0.00045
                 T.STTT-EEEEETTTEEEEEECTTE CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGy 28 
                   Cs++G C+ +     tC+C +Gy
  EFC35767.1 266 EvCSGHGDCIAVD----TCKCYQGY 286
                 25***********....*******9 PP

>> OppC_N  N-terminal TM domain of oligopeptide transport permease C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   4.7    0.0011       4.8      18      36 ..     424     442 ..     423     450 .. 0.90

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0011
      OppC_N  18 vglvilllllliaifaPli 36 
                 v+l ++++++l++++ P+i
  EFC35767.1 424 VALLLIIIIVLLSFLSPYI 442
                 78999************** PP

>> DUF346  Repeat of unknown function (DUF346)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.52   2.3e+03      29      34 ..       2       7 ..       1      11 [. 0.79
   2 ?   -2.5   0.1      0.98   4.4e+03      28      36 ..      40      48 ..      39      50 .. 0.76
   3 ?   -0.3   0.1       0.2     9e+02      28      38 ..      87      97 ..      85      98 .. 0.89
   4 ?    2.9   0.0     0.021        95      26      38 ..     124     136 ..     118     137 .. 0.84
   5 ?   -2.8   0.1       1.2   5.4e+03      31      38 ..     139     146 ..     138     146 .. 0.90
   6 ?    4.4   0.0     0.007        31      24      38 ..     160     174 ..     155     175 .. 0.83
   7 ?   -3.6   0.1       2.3     1e+04      28      35 ..     246     253 ..     244     255 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.52
      DUF346 29 WgGtia 34
                WgG++ 
  EFC35767.1  2 WGGQFC 7 
                ****96 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.98
      DUF346 28 dWgGtiagd 36
                 WgG++ + 
  EFC35767.1 40 GWGGKLCTI 48
                5***98765 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.2
      DUF346 28 dWgGtiagdPt 38
                 W G + ++Pt
  EFC35767.1 87 GWTGPLCSTPT 97
                6*********8 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.021
      DUF346  26 radWgGtiagdPt 38 
                 + dWgG++ + Pt
  EFC35767.1 124 YRDWGGEFCTIPT 136
                 679*****99887 PP

  == domain 5  score: -2.8 bits;  conditional E-value: 1.2
      DUF346  31 GtiagdPt 38 
                 Gt+a+dPt
  EFC35767.1 139 GTLATDPT 146
                 99****98 PP

  == domain 6  score: 4.4 bits;  conditional E-value: 0.007
      DUF346  24 lkradWgGtiagdPt 38 
                  + ++WgG++  +Pt
  EFC35767.1 160 CRCNSWGGKLCATPT 174
                 6789*********98 PP

  == domain 7  score: -3.6 bits;  conditional E-value: 2.3
      DUF346  28 dWgGtiag 35 
                 +WgG   g
  EFC35767.1 246 NWGGFMCG 253
                 8**96655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1109  (0.0618551); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.72u 0.27s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 2822.88
//
Query:       EFC35768.1  [L=615]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.043   13.7   0.9        0.9    9.5   0.1    3.3  3  F-box       F-box domain
       0.19   11.6   0.6        1.5    8.8   0.1    2.4  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.1    0.0001       0.9      21      40 ..      67      86 ..      46      89 .. 0.86
   2 ?   -3.5   0.0       1.2     1e+04      11      21 ..     122     132 ..     108     134 .. 0.86
   3 ?    0.5   0.0     0.065   5.8e+02      22      38 ..     191     207 ..     183     210 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.0001
                HHHHHHCTT-HHHHHHHTTH CS
       F-box 21 sdllalrrVSkgwrilidsd 40
                 +l+a++ V+  wr++++++
  EFC35768.1 67 HTLIAFAGVCSEWRRIVKEC 86
                579**************976 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.2
                 HHHHHHTS-HH CS
       F-box  11 lrhILerLpls 21 
                 l++I+++++ +
  EFC35768.1 122 LLQIFSQMEIR 132
                 78999999876 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.065
                 HHHHHCTT-HHHHHHHT CS
       F-box  22 dllalrrVSkgwrilid 38 
                 ++ +lr  ++++ +l+d
  EFC35768.1 191 EVENLRTICTNLLNLTD 207
                 6889**********987 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.1   0.00016       1.5      14      37 ..      62      85 ..      47      88 .. 0.75
   2 ?   -0.1   0.0     0.099   8.9e+02       9      17 ..     122     130 ..     122     136 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00016
  F-box-like 14 syLppsdLlrlalVCrrWrrvald 37
                 y +  +L++ a VC+ Wrr++  
  EFC35768.1 62 PYFNSHTLIAFAGVCSEWRRIVKE 85
                3666778999***********965 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.099
  F-box-like   9 LlqIFsyLp 17 
                 LlqIFs+++
  EFC35768.1 122 LLQIFSQME 130
                 8*****976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (615 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       668  (0.0372581); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 3969.29
//
Query:       EFC35769.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
          2    6.9  20.9        2.6    6.5  20.9    1.2  1  Macoilin     Macoilin family
        3.3    8.5   5.4        0.7   10.7   0.1    2.4  3  CaM_binding  Plant calmodulin-binding domain


Domain annotation for each model (and alignments):
>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  20.9   0.00029       2.6     231     390 ..      71     240 ..      17     285 .. 0.53

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.00029
    Macoilin 231 pvalsknnhslnkkdsslklpeleyrekkksakssrsdskkkhehn..........esvdsklqekeymenkskskrlsksessgsesellveesvksk 319
                     +kn  ++ ++  ++ l++l+ ++++ ++ ++++d++     +          ++  +++q+++  ++++++++ ++ +s++++++l ++  ++s+
  EFC35769.1  71 GIFSQKNVDTMMNNIIQQILSTLSVQQERMNNIEQKQDHGF----AsgntssmlvpNASTDQHQKIQACTSHVNHQQPETPSSNANQQQLVMDRGSTSS 165
                 22222232222222333344445544444444444444333....244457777777777788888888888887777666666666665555443333 PP

    Macoilin 320 ssssssssnknskkasagsagssnssskkhsessks.vtsssssknskkqklpaGkssa......alkdaaenslpnn 390
                  +  s +     +  s++  +ss s s++  +ss+s  tssss ++skk  l+ G +s+      a+++++  s +n+
  EFC35769.1 166 FNNGSGD--VGLQ-GSSSFPSSSHSLSNNTTNSSSStSTSSSSFNDSKKFMLSPGTNSStlefinAHNNPMLASSANQ 240
                 3222222..2222.2333334444444444444444045555666777777766766653433333333333344444 PP

>> CaM_binding  Plant calmodulin-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   7.8e-05       0.7      52     101 ..      47      97 ..       7     100 .. 0.68
   2 ?   -0.2   0.3      0.18   1.6e+03      27      61 ..     121     154 ..      94     160 .. 0.55
   3 ?   -2.2   0.1      0.76   6.8e+03      17      22 ..     205     210 ..     182     254 .. 0.55

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 7.8e-05
  CaM_binding  52 rkprelpeesek.eaekVvLrhqd.veekkkaeewllnnvieetaskLvear 101
                  ++ re +++s++  +  ++ r  + +  +k+ ++ ++nn+i++++s+L  ++
   EFC35769.1  47 DTRREYSSSSSSlVSSSIQSRGLEgIFSQKNVDT-MMNNIIQQILSTLSVQQ 97 
                  3333333333444777777776643667788888.*************8765 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.18
  CaM_binding  27 rkrkkaleekeskke.ereslrkfnprkprelpees 61 
                     ++++ ++++k + ++  ++ ++p++p+++++++
   EFC35769.1 121 VP-NAST-DQHQKIQaCTSHVNHQQPETPSSNANQQ 154
                  33.3233.4556666688888888888887776554 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.76
  CaM_binding  17 swsslr 22 
                  s +  +
   EFC35769.1 205 SFNDSK 210
                  222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1422  (0.0793128); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 2032.76
//
Query:       EFC35770.1  [L=558]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   15.7   2.3      0.013   15.7   2.3    3.1  3  Shisa     Wnt and FGF inhibitory regulator
      0.034   12.9   5.1      0.028   13.2   3.7    1.5  1  p450      Cytochrome P450
        1.1    9.2   3.8        6.4    6.6   1.4    2.3  2  Dak2      DAK2 domain


Domain annotation for each model (and alignments):
>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   4.3       0.7   4.2e+03     129     175 ..      86     137 ..      39     152 .. 0.53
   2 ?   -0.9   1.3      0.28   1.7e+03     107     150 ..     131     173 ..     114     205 .. 0.65
   3 ?   15.7   2.3   2.2e-06     0.013      81     164 ..     461     551 ..     436     557 .. 0.55

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.7
       Shisa 129 laev.gpivte.ttsattvvhsrys...epqqssssssypgatnqgyqpvpv 175
                 ++++   iv + +t+++t+++s  +   ++q+ s + +   at+q+ q++p 
  EFC35770.1  86 VVTTiTQIVHQvNTQTNTIMSSFVKdgdSSQSISQTINTIVATTQMLQALPE 137
                 2222233444444555555544332110222222223333333444444443 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.28
       Shisa 107 ccgclkkkqrekrpgrenlssalaevgpivtettsattvvhsry 150
                 + + l + ++++++   n+++ l+++ +  tetts++t+++s  
  EFC35770.1 131 MLQAL-PESEKSSTTITNIQTTLLDILANATETTSEETISKSIS 173
                 33332.23333336777788888888555555666666666654 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 2.2e-06
       Shisa  81 d.....iyvpvlivktifivfvivgvvvivcccgclkkkqrekr.pgrenl.ssalaev...gpivtettsattvvhsrysepqqssssssypg 164
                 +     i+++ +i++t++i+ +   +  + +++ c++  +r+k+ p++e+  ss  ae+   +pi +     ++ ++s+y+e+++++s++s+  
  EFC35770.1 461 NltthiIIISAVIGGTCLISVTCFFIALVAVVIYCIRGCGRRKTrPHEEKDnSSDGAEMvirIPIAQ---MISLPSQSPYQESANTTSTQSQGS 551
                 1223347788899999999754443333334444555555555444444430333344443445444...777778888877666666654433 PP

>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   3.7   4.6e-06     0.028     173     279 ..      58     164 ..      40     177 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.6e-06
                 HHHHHHHHHHHHHCHHHHCCCCCH.HHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC.SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHH CS
        p450 173 lvkaveelssllskssvqllllfp.llkylptkllrklkeavkklkdlldklieerretldsa.kksrrdfldalllakkekkgesklsdeelaatvle 269
                  vk + el +   +  ++++ +   +++++ t + + ++++  + + ++  ++++  ++ + + + ++   +  +l+a   ++++s+ + +++++t+l+
  EFC35770.1  58 VVKIFVELTDTH-TGEFRIMYYHVtVMRVVVTTITQIVHQVNTQTNTIMSSFVKDGDSSQSISqTINTIVATTQMLQA-LPESEKSSTTITNIQTTLLD 154
                 455555554444.4444454444459***************9999999999**9999998888323334444444444.35666689************ PP

                 HHHHHHHHHH CS
        p450 270 llfaGvdTts 279
                 +l+ +++Tts
  EFC35770.1 155 ILANATETTS 164
                 *********9 PP

>> Dak2  DAK2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   1.4    0.0011       6.4      49     122 ..     101     175 ..      79     186 .. 0.69
   2 ?    3.0   0.1     0.014        82      16      65 ..     181     232 ..     172     263 .. 0.72

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0011
                 HHHHHHHHHHHHHHHC......TT---HHHHHHHHHHHHHHHH---TTSSSTHHHHHHHHHHHHT.......... CS
        Dak2  49 sGvlysqflralakalkekee.ldaedlaaalkaaleaiqavgkarpgdkTmlDvlrpavealekakdgedlkea 122
                   +++s+f +   ++ + +++  ++ +  ++l+a  e+ ++ +  +  + T+lD+l+ a e+ ++++ ++++  +
  EFC35770.1 101 TNTIMSSFVKDGDSSQSISQTiNTIVATTQMLQALPESEKSSTTITNIQTTLLDILANATETTSEETISKSISSM 175
                 555666666655444444333136666778888888999999********************9994434555554 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.014
                 HHHHHHHHC---SSHHHHHHHHHHHHHHH--STHHH..HHHHHHHHHHHHC. CS
        Dak2  16 eavlkaleeleeaslaevlkalakallsgagGtsGv..lysqflralakalk 65 
                 + +lk+ ++  +a +++ ++al ++++++++++ Gv    sq +++++++l 
  EFC35770.1 181 HTMLKNEHNIGQAVIEKSVNALENIVEQNFRSNVGVssQTSQTFMSVVENLV 232
                 5566666667889999999999999999999999983336777777777663 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (558 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1532  (0.0854482); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 3811.77
//
Query:       EFC35771.1  [L=721]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.6   2.6        1.2    9.4   0.4    2.6  2  RecJ_OB   RecJ OB domain


Domain annotation for each model (and alignments):
>> RecJ_OB  RecJ OB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.4   6.7e-05       1.2      33     100 ..     429     490 ..     426     494 .. 0.86
   2 ?    2.2   0.1     0.011     2e+02      29      95 ..     550     612 ..     547     620 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 6.7e-05
     RecJ_OB  33 fllknvkvesarivgkeknhlklkledesgksleaiaFnlaekleelekgdkvdiaytleinefngre 100
                 fl+kn +ve+ + +gk k+h+kl+   ++ + ++ i F ++++     k  +++++ +++ n+fn  +
  EFC35771.1 429 FLQKN-TVEKLKEIGK-KEHIKLSKLTKD-EIIQKIQFICNSTNV---KSLQLHALHSFDQNQFNATS 490
                 89999.**********.*******99888.999999999988877...57789999999999999766 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.011
     RecJ_OB  29 pePvfllknvkvesarivgkeknhlklkledesgksleaiaFnlaekleelekgdkvdiaytleine 95 
                 +  +f ++ v v++ +i+ ++++ + ++  ++++ + + i F+  +        ++ +i yt+ +n+
  EFC35771.1 550 HIATFDTNTVLVSERSIMERKQQDVSISTFKKESINSNLISFSFVDIST----VNNQSISYTFHLNS 612
                 556899999***********9999999886666699999***9977655....44555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (721 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1029  (0.0573931); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 4335.93
//
Query:       EFC35772.1  [L=152]
Description: polyubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.4e-63  208.7   7.1    5.3e-32  109.4   0.6    2.0  2  ubiquitin    Ubiquitin family
    3.2e-29  100.5   7.8    3.6e-15   55.6   0.6    2.0  2  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
    6.6e-10   39.3   4.5    0.00027   21.3   0.8    3.1  2  Ubiquitin_2  Ubiquitin-like domain
    7.8e-09   35.6   0.4     0.0021   18.2   0.0    2.8  2  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
    7.9e-09   35.3   0.6     0.0022   17.9   0.1    2.2  2  TBK1_ULD     TANK binding kinase 1 ubiquitin-like domain
    8.4e-08   32.7   0.1     0.0022   18.6   0.0    2.2  2  DUF2407      DUF2407 ubiquitin-like domain
    1.6e-07   31.6   2.3     0.0075   16.6   0.2    2.1  2  Ubiquitin_5  Ubiquitin-like domain
      9e-05   22.4   8.1        3.7    7.7   0.2    4.0  4  Ubiquitin_4  Ubiquitin-like domain
  ------ inclusion threshold ------
      0.024   14.8   0.3        2.4    8.4   0.0    2.4  2  DUF3861      Domain of Unknown Function with PDB structure (D
      0.028   14.2   0.7        2.3    8.0   0.1    2.4  2  PI3K_p85B    PI3-kinase family, p85-binding domain
      0.072   13.5   0.1        2.8    8.4   0.0    2.1  2  PilN_bio_d   PilN biogenesis protein dimerization domain
       0.18   12.2   2.0        4.7    7.6   0.3    2.9  3  bPH_3        Bacterial PH domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.4   0.6   3.5e-35   5.3e-32       1      72 []       3      74 ..       3      74 .. 0.99
   2 !  103.2   1.0   3.1e-33   4.6e-30       1      72 []      79     150 ..      79     150 .. 0.99

  Alignments for each domain:
  == domain 1  score: 109.4 bits;  conditional E-value: 3.5e-35
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                ++vktl+gk+itleve++d++e++K k+++kegip+eqqrLiy+Gk+Led rt+ +y+iq++stlhlvlrlr
  EFC35772.1  3 LFVKTLTGKTITLEVESNDSIENVKRKVQDKEGIPPEQQRLIYAGKQLEDGRTINDYNIQKDSTLHLVLRLR 74
                79*******************************************************************986 PP

  == domain 2  score: 103.2 bits;  conditional E-value: 3.1e-33
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 ++vktl+gk+it+e+e++dt+++ K+ki +kegip +qqrLiy+Gk+Led r l++y++q++st+hlvlrlr
  EFC35772.1  79 LFVKTLTGKTITIEMESNDTIQNMKQKIFDKEGIPSDQQRLIYAGKQLEDGRQLSDYNLQKDSTVHLVLRLR 150
                 79*******************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.6   0.6   2.4e-18   3.6e-15       1      72 []       1      71 [.       1      71 [. 0.98
   2 !   49.2   1.4   2.3e-16   3.4e-13       1      72 []      77     147 ..      77     147 .. 0.98

  Alignments for each domain:
  == domain 1  score: 55.6 bits;  conditional E-value: 2.4e-18
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                +++++k+ +gk+++++V+++  +++++++ ++k+gip+ +++rLi+ G++L++  t++d+ i++++t+++v+
  EFC35772.1  1 MQLFVKTLTGKTITLEVESNDSIENVKRKVQDKEGIPP-EQQRLIYAGKQLEDGRTINDYNIQKDSTLHLVL 71
                79************************************.******************************986 PP

  == domain 2  score: 49.2 bits;  conditional E-value: 2.3e-16
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 +++++k+ +gk+++i+ +++ t+++++++  +k+gip  +++rLi+ G++L++  ++ d+ +++++t+++v+
  EFC35772.1  77 MQLFVKTLTGKTITIEMESNDTIQNMKQKIFDKEGIPS-DQQRLIYAGKQLEDGRQLSDYNLQKDSTVHLVL 147
                 79************************************.******************************996 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.2   2.5e-06    0.0038      18      79 ..      15      68 ..       3      71 .. 0.79
   2 !   21.3   0.8   1.8e-07   0.00027      14      80 ..      87     145 ..      77     146 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 2.5e-06
                 EEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2 18 rrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79
                   ++++++ie++K+k++   G++p+++rL +          k  +d ++ ++Y+++  +++h
   EFC35772.1 15 LEVESNDSIENVKRKVQDKEGIPPEQQRLIYA--------GKQLEDGRTINDYNIQKDSTLH 68
                 5678899**********************997........4445677777777777777777 PP

  == domain 2  score: 21.3 bits;  conditional E-value: 1.8e-07
                  SEEEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2  14 vsserrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                  +  ++ +++++ti+++K+k+    G++ +++rL +          k  +d ++L++Y+++  +++h 
   EFC35772.1  87 KTITIEMESNDTIQNMKQKIFDKEGIPSDQQRLIYA--------GKQLEDGRQLSDYNLQKDSTVHL 145
                  567788999************************998........556789999*****999999995 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.1   1.8e-05     0.028      12      87 ..      10      71 ..       2      75 .. 0.72
   2 !   18.2   0.0   1.4e-06    0.0021      11      87 ..      85     147 ..      77     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.8e-05
                 S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2 12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87
                 G+ +  ++ +++++++++k+kv     +dke  p  +++ +li+aGk Le+ +t+++++++        +++H+v+
   EFC35772.1 10 GK-TITLEVESNDSIENVKRKV-----QDKEGIP--PEQQRLIYAGKQLEDGRTINDYNIQKD------STLHLVL 71
                 55.5566778888888888888.....4566633..34569***************9965433......3466665 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 1.4e-06
                  TS-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  11 dGsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                   G+ +  +++++++t++++k+k++++     e  p++    +li+aGk Le+ ++l++++l+         ++H+v+
   EFC35772.1  85 TGK-TITIEMESNDTIQNMKQKIFDK-----EGIPSDQ--QRLIYAGKQLEDGRQLSDYNLQKDS------TVHLVL 147
                  577.77788999************74.....4445544..48****************9655433......466665 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   5.5e-06    0.0083      19      55 ..      17      51 ..       8      72 .. 0.83
   2 !   17.9   0.1   1.5e-06    0.0022      15      53 ..      89     127 ..      80     145 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5.5e-06
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrllle 55
                +++++ ++++  +v+++  i++e+Q l++ g++l  e
  EFC35772.1 17 VESNDSIENVKRKVQDKEGIPPEQQRLIYAGKQL--E 51
                6789999*************************87..3 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 1.5e-06
    TBK1_ULD  15 hkiYihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 ++i +++++t++++ ++++++  i++++Q l++ g++l 
  EFC35772.1  89 ITIEMESNDTIQNMKQKIFDKEGIPSDQQRLIYAGKQLE 127
                 66778999****************************973 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0   0.00012      0.18      15      63 ..      14      58 ..       7      72 .. 0.78
   2 !   18.6   0.0   1.4e-06    0.0022      16      64 ..      89     135 ..      79     148 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00012
     DUF2407 15 eLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslas 63
                +L+++  ++ +++++k+ + ++    +  ++ rLIyaG+ Led  ++++
  EFC35772.1 14 TLEVE--SNDSIENVKRKVQDKE--GIPPEQQRLIYAGKQLEDGRTIND 58
                56666..5567788888888876..67777889**********998865 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 1.4e-06
     DUF2407  16 LdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslass 64 
                 ++i+  ++ t++++kq i ++    + s + rLIyaG+ Led  +l++ 
  EFC35772.1  89 ITIEMESNDTIQNMKQKIFDKE--GIPSDQQRLIYAGKQLEDGRQLSDY 135
                 678888899**********998..88888889*************9875 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1   1.7e-05     0.025      33      93 ..      12      73 ..       5      78 .. 0.83
   2 !   16.6   0.2     5e-06    0.0075      34      93 ..      89     149 ..      81     151 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.7e-05
  Ubiquitin_5 33 kklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93
                   +le++ + + +++ +k+ ++ g+  ++ +li+ gk+le ++t+++ +++++s + +vL+l
   EFC35772.1 12 TITLEVESNDSIENVKRKVQDKEGIPPEQQRLIYAGKQLEDGRTINDYNIQKDSTLhLVLRL 73
                 5567777777888899999999999999**********************999875467765 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 5e-06
  Ubiquitin_5  34 klletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                   ++e++ + t +++ +ki ++ g+  ++ +li+ gk+le +++L + +++++s v +vL+l
   EFC35772.1  89 ITIEMESNDTIQNMKQKIFDKEGIPSDQQRLIYAGKQLEDGRQLSDYNLQKDSTVhLVLRL 149
                  5667777778999*************************************99998567765 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.2    0.0028       4.2       1      33 [.       1      33 [.       1      42 [. 0.92
   2 !    6.6   0.1    0.0053         8      58      86 ..      43      70 ..      38      73 .. 0.84
   3 !    7.7   0.2    0.0024       3.7       1      30 [.      77     106 ..      77     118 .. 0.91
   4 ?    4.1   0.0     0.031        47      58      86 ..     119     146 ..     115     149 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0028
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaierk 33
                 +++ vk l g+++ ++v++n +++++k+ ++ k
   EFC35772.1  1 MQLFVKTLTGKTITLEVESNDSIENVKRKVQDK 33
                 78999************************9975 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0053
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L++ g++L+ d  ++++y i+++s+l+ v
   EFC35772.1 43 LIYAGKQLE-DGRTINDYNIQKDSTLHLV 70
                 889999986.6789************976 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0024
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkai 30 
                  +++ vk l g+++ +++++n t++++k+ i
   EFC35772.1  77 MQLFVKTLTGKTITIEMESNDTIQNMKQKI 106
                  78999**********************988 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.031
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L++ g++L+ d  +l++y ++++s+++ v
   EFC35772.1 119 LIYAGKQLE-DGRQLSDYNLQKDSTVHLV 146
                  889999986.6679**********99876 PP

>> DUF3861  Domain of Unknown Function with PDB structure (DUF3861)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.0    0.0016       2.4      19      60 ..       9      50 ..       5      84 .. 0.89
   2 ?    4.6   0.1     0.025        38      19      59 ..      85     125 ..      78     128 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0016
     DUF3861 19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglkL 60
                + k++++e+e+ d i ++ +++++ke++ +++++ +  g +L
  EFC35772.1  9 TGKTITLEVESNDSIENVKRKVQDKEGIPPEQQRLIYAGKQL 50
                5579*************************9998877766655 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.025
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d i ++ +++ +ke++ +d+++ +  g +
  EFC35772.1  85 TGKTITIEMESNDTIQNMKQKIFDKEGIPSDQQRLIYAGKQ 125
                 5579************************9999887766655 PP

>> PI3K_p85B  PI3-kinase family, p85-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.1     0.022        33       1      18 [.      13      30 ..      13      34 .. 0.92
   2 ?    8.0   0.1    0.0015       2.3       1      21 [.      89     109 ..      89     111 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.022
   PI3K_p85B  1 itlrvsreatLseiKeeL 18
                itl+v+++ +++++K+++
  EFC35772.1 13 ITLEVESNDSIENVKRKV 30
                89*************987 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0015
   PI3K_p85B   1 itlrvsreatLseiKeeLwee 21 
                 it++++++ t++++K++++++
  EFC35772.1  89 ITIEMESNDTIQNMKQKIFDK 109
                 899***************985 PP

>> PilN_bio_d  PilN biogenesis protein dimerization domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.072   1.1e+02      15      49 ..      18      52 ..       6      70 .. 0.81
   2 ?    8.4   0.0    0.0019       2.8      12      67 ..      91     146 ..      81     149 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.072
                GGGEEEEEEEEEE--HHHHHHHHHTTGGGG--ECE CS
  PilN_bio_d 15 essvalsslsvravdagalealqqegvydgkavsr 49
                es+ ++++++ +  d++  +  qq+ +y+gk+++ 
  EFC35772.1 18 ESNDSIENVKRKVQDKEGIPPEQQRLIYAGKQLED 52
                5667888999999999999999*********9875 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0019
                 S--GGGEEEEEEEEEE--HHHHHHHHHTTGGGG--ECEEEEEEEEESSHHHHHHHH CS
  PilN_bio_d  12 lpsessvalsslsvravdagalealqqegvydgkavsreldlsGeArsqqavvnfl 67 
                 +  es+ ++++++ +  d++  ++ qq+ +y+gk+++   +ls   +++++ v+++
  EFC35772.1  91 IEMESNDTIQNMKQKIFDKEGIPSDQQRLIYAGKQLEDGRQLSDYNLQKDSTVHLV 146
                 55667778999*************************99999998888888877765 PP

>> bPH_3  Bacterial PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0       0.5   7.5e+02      70      92 ..       6      29 ..       2      32 .. 0.62
   2 ?    7.6   0.3    0.0031       4.7      30      92 ..      41     105 ..      39     108 .. 0.84
   3 ?    1.5   0.0      0.25   3.7e+02      29      56 ..     116     143 ..     114     149 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.5
       bPH_3 70 et.sgktitidnidksevrkivea 92
                +t  gktit++  ++++++++ + 
  EFC35772.1  6 KTlTGKTITLEVESNDSIENVKRK 29
                455677777776666666666555 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0031
       bPH_3  30 kRiifldpkmfggkdfeeipYksIksvdlkkgl.lgakitlet.sgktitidnidksevrkivea 92 
                 +R+i+  ++   g++++++  ++ +  +l  +l  g ++ ++t  gktiti++ ++++++++ + 
  EFC35772.1  41 QRLIYAGKQLEDGRTINDYNIQKDSTLHLVLRLrGGMQLFVKTlTGKTITIEMESNDTIQNMKQK 105
                 89999999999999999999999999999988877777888999999999999899999988766 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.25
       bPH_3  29 nkRiifldpkmfggkdfeeipYksIksv 56 
                 ++R+i+  ++   g++  ++ +++ + v
  EFC35772.1 116 QQRLIYAGKQLEDGRQLSDYNLQKDSTV 143
                 58********999999999999885555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       668  (0.0372581); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 955.02
//
Query:       EFC35773.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.021   15.2   1.0      0.032   14.6   1.0    1.4  1  DUF2122          RecB-family nuclease (DUF2122)
      0.028   14.3   0.4      0.028   14.3   0.4    2.4  2  Prefoldin_2      Prefoldin subunit
      0.035   14.0   0.2      0.045   13.6   0.2    1.1  1  Oxidored_q6      NADH ubiquinone oxidoreductase, 20 Kd subuni
      0.045   13.8   0.3      0.054   13.5   0.3    1.2  1  AAA_14           AAA domain
      0.049   13.5   0.1      0.062   13.2   0.1    1.1  1  Methyltrn_RNA_4  SAM-dependent RNA methyltransferase
        1.5    9.3   5.5        7.3    7.1   0.4    2.6  3  MKRN1_C          E3 ubiquitin-protein ligase makorin-1, C-ter


Domain annotation for each model (and alignments):
>> DUF2122  RecB-family nuclease (DUF2122)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   1.0   1.1e-05     0.032      24      85 ..      41      96 ..      25     112 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.1e-05
     DUF2122 24 vlpdlkDalellkpekvlllskeegeelleeeeleekgrvllvfsgadegfskke.lelgetv 85
                 +++++Dal  l       l+k+  ee++++  ++++++vl+v +++de  +k+e l++ ++ 
  EFC35773.1 41 LIDEISDALHRL------SLQKQ-TEEMIKKLVEQKDQSVLIVAGSGDETSDKLEtLQKMQQE 96
                567888888888......45554.89999999999*****************99976665554 PP

>> Prefoldin_2  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   2.5      0.11   3.2e+02      27      92 ..      41      65 ..      31      72 .. 0.51
   2 ?   14.3   0.4   9.5e-06     0.028      30      64 ..      82     116 ..      78     118 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.11
                 HHHHHHHHHHHHHHS-TT--EEEEETTEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2 27 qlkelelvleelelldedtkvyklvGdvlvkqdkeevkeeLeerketlekeiktlekqleklekel 92
                  ++e+ ++l  l+l ++                                          e++ k+l
   EFC35773.1 41 LIDEISDALHRLSLQKQ-----------------------------------------TEEMIKKL 65
                 44444444444444444.........................................44444444 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 9.5e-06
                  HHHHHHHHHHHS-TT--EEEEETTEEEEE-HHHHH CS
  Prefoldin_2  30 elelvleelelldedtkvyklvGdvlvkqdkeevk 64 
                  e  + le+l+++ ++++v  +vG++l+++d ++++
   EFC35773.1  82 ETSDKLETLQKMQQEEMVVLKVGGMLLLFDDDDLN 116
                  667789************************99986 PP

>> Oxidored_q6  NADH ubiquinone oxidoreductase, 20 Kd subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.2   1.5e-05     0.045       9      80 ..      35     104 ..      28     105 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.5e-05
                  T-TTTTHHHHHHTEEEEEETTT-S--HHH..HHHTHTTTSEEEEEESBE...EEEHHHHHHHHGGGSSEEEEES CS
  Oxidored_q6   9 laleedlldllelielryhetlladskee..eieakekeadvlvveGavtrkpkealellkelaekakaviavG 80 
                  ++ +e+l+d    i+ ++h   l+++ ee  +   ++k++ vl+v G+   ++ ++le+l+++ ++  +v  vG
   EFC35773.1  35 NDQNEKLIDE---ISDALHRLSLQKQTEEmiKKLVEQKDQSVLIVAGSG-DETSDKLETLQKMQQEEMVVLKVG 104
                  5555555555...55555444444444445855666789**********.999************999999988 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.3   1.8e-05     0.054      58     105 ..      30      84 ..       4     107 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.8e-05
      AAA_14  58 eklkeekktylflDEiqev.......pewekalkslvdegknldvivtGSnskll 105
                 +++ e++++  ++DEi+ +       ++ e+++k+lv+++++  +iv+GS     
  EFC35773.1  30 SEVFENDQNEKLIDEISDAlhrlslqKQTEEMIKKLVEQKDQSVLIVAGSGDETS 84 
                 222223444469****************************9999******76654 PP

>> Methyltrn_RNA_4  SAM-dependent RNA methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   2.1e-05     0.062      64     135 ..      34     101 ..      27     112 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.1e-05
                      HTSGGGGT-SSSHHHHTTEEEESSHHHHHHHHHHHHSS--EEEE--SS--SS-B-HHHHHHHHHH--S-EEE CS
  Methyltrn_RNA_4  64 tegagaeynpdRkealslvkvvesleealeeiekeegkkplvvatsArkkentvsyeelrelleeeekpvll 135
                      ++++++++  + ++al+++++ ++ ee+++++ +++++++l+va s  ++++++++  l+++   +e+ v+l
       EFC35773.1  34 ENDQNEKLIDEISDALHRLSLQKQTEEMIKKLVEQKDQSVLIVAGSGDETSDKLET--LQKMQ--QEEMVVL 101
                      56677777888899*******************************99977666543..33333..3333333 PP

>> MKRN1_C  E3 ubiquitin-protein ligase makorin-1, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.4    0.0024       7.3      28      61 ..      28      61 ..       5      64 .. 0.82
   2 ?   -1.3   0.0      0.96   2.9e+03      52      63 ..      74      85 ..      63      91 .. 0.82
   3 ?    3.8   0.5     0.025        75      35      51 ..      93     109 ..      82     117 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0024
     MKRN1_C 28 esespfdnddeelvtfeLselLlmllaagaddEl 61
                +s++ f+nd++e ++ e+s+ L +l++  + +E+
  EFC35773.1 28 ASSEVFENDQNEKLIDEISDALHRLSLQKQTEEM 61
                68899********************999988886 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.96
     MKRN1_C 52 llaagaddEltd 63
                l++ag++dE +d
  EFC35773.1 74 LIVAGSGDETSD 85
                678888999887 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.025
     MKRN1_C  35 nddeelvtfeLselLlm 51 
                  ++ee+v+++++ +Ll 
  EFC35773.1  93 MQQEEMVVLKVGGMLLL 109
                 4679***********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2132  (0.118913); expected 358.6 (0.02)
Passed bias filter:                      905  (0.0504769); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 751.43
//
Query:       EFC35774.1  [L=736]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-27   96.4   0.6    3.1e-27   95.6   0.6    1.4  1  Pkinase         Protein kinase domain
    5.9e-17   62.0   1.0    1.4e-08   35.2   0.3    2.5  2  Ank_2           Ankyrin repeats (3 copies)
    7.4e-14   51.7   0.0    1.6e-13   50.6   0.0    1.6  1  Pkinase_Tyr     Protein tyrosine kinase
    3.2e-13   48.5   2.7       0.14   12.8   0.0    6.6  7  Ank_3           Ankyrin repeat
      7e-13   48.5   1.8     0.0052   17.1   0.0    3.8  3  Ank_5           Ankyrin repeats (many copies)
    1.7e-08   34.9   0.4      0.045   14.3   0.0    4.1  5  Ank_4           Ankyrin repeats (many copies)
    5.2e-06   26.7   0.0       0.82   10.2   0.0    4.2  3  Ank             Ankyrin repeat
    0.00083   18.2   0.0     0.0014   17.5   0.0    1.3  1  Pkinase_fungal  Fungal protein kinase
     0.0016   17.9   0.1     0.0053   16.1   0.0    1.8  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.012   15.0   0.2      0.026   13.8   0.0    1.6  2  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.6   0.6   1.7e-30   3.1e-27      69     260 ..     525     730 ..     469     732 .. 0.80

  Alignments for each domain:
  == domain 1  score: 95.6 bits;  conditional E-value: 1.7e-30
                 E.......SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET...TTE...EEE-SGTTSEESSSSCSB CS
     Pkinase  69 e.......kdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide...kge...lKitDFGlakelessskl 154
                 +       k++l++ ++y ++g+l++l+++k++l+e+ +kk+++qi+  l+y+ +++i+Hr +Kp+NiL+ e   + e     ++ F l+k ++ s + 
  EFC35774.1 525 QnsndltnKSTLCVEMDYYDKGSLESLIKQKVVLKEAVIKKFISQIIGTLQYMNKHKIVHRNIKPHNILLREwdpS-EnidTVLIGFRLSKSVSDSASD 622
                 0555555599999*********************************************************965552.1456999*************** PP

                 CTTTSCGGGS-HHHH.......TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT..SHH...HHHTTS-HHHHHHHHHH CS
     Pkinase 155 tsfvgtseYlAPEvl.......keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..etkeklpeaseiseeakdllkkl 244
                  ++ g+ ++++PE+l       +++ + +++D+++lGv++y+llt  ++    +g     k      +  k+++   ++   ++++  s  + +l+ ++
  EFC35774.1 623 IQQAGSLQFIPPELLdiseeleENTAMFASADIFALGVTCYQLLTFDTVTM-INGLI--MKYG----NEEKVMNhlRSSIIKNQHYPYSTGLVELVISM 714
                 *****************998855566699********************99.44433..2222....234455522224444556666*********** PP

                 T-SSGCCSTTHHHHHT CS
     Pkinase 245 lkkdpkkRltaeellq 260
                 l+ +  +R+t +e+l+
  EFC35774.1 715 LRLNTADRITLDEILD 730
                 ************9986 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.0   1.1e-08     2e-05       3      80 ..     115     202 ..      99     205 .. 0.84
   2 !   35.2   0.3     8e-12   1.4e-08      10      83 .]     236     325 ..     227     325 .. 0.77

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 1.1e-08
       Ank_2   3 lAakngnlelvklLl..egadpn..k.ngktaLhyAakngnleivklLleh...ad..ndgrtpLhyAarsghleivklLlekgadin 80 
                  ++++gn+e+v+ ++   +a +n  +  g taL +A+ + n +++k+L+     ++   +gr++L+y+ + + + ++ +L+  ga+++
  EFC35774.1 115 KMVREGNYEMVEAMInnREAGINdcDtSGCTALGVAVDSVNMKMLKFLIRRggnTNgiIYGRSILQYCMERNLIPFASYLIRMGAKPK 202
                 56788999*******5433444453269**********999999*****97766668888*********9999********7799876 PP

  == domain 2  score: 35.2 bits;  conditional E-value: 8e-12
       Ank_2  10 lelvklLl.egadpn....k....ngktaLhyAakngnleivklLleh...ad....ndgrtpLhyAarsghleivklLlekgadinlkd 83 
                 +e  ++L+ ++ + n    +    + +t+L++  k++n e+v++L++h   +d    + +++ L++A++++h ++vk L+++ga++ ++d
  EFC35774.1 236 FERANYLItKNLKHNilivDclnqERETPLYALSKHNNPEAVEWLIKHgaqVDlkvmDRNMNSLQVAIQCKHWNVVKTLIKNGANMYIRD 325
                 55667777644333333331333588*********************99884466767899*******************99***99886 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.6   0.0   8.9e-17   1.6e-13      30     259 .]     475     732 ..     453     732 .. 0.79

  Alignments for each domain:
  == domain 1  score: 50.6 bits;  conditional E-value: 8.9e-17
                  EEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE........SSSS..........EEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHH CS
  Pkinase_Tyr  30 kVavKtlkeeateeekeelleeakimkklkhpnivkllgvct........keep..........llivteyvkgGdLlkfLrkkekekltlkdllsfa 109
                   +avK ++  +te   ++ l+ a  + kl++++i+ +  v +        +  +          l++ ++y ++G+L++ +++k    l+   + +f+
   EFC35774.1 475 VIAVKLVDFFSTEA-LNKSLKSAMNLIKLRQDHIIGVRDVAVlkckipenN--QnsndltnkstLCVEMDYYDKGSLESLIKQK--VVLKEAVIKKFI 567
                  56788775555555.666666677777777777777666655445555431..134566666669999*************998..999999999*** PP

                  HHHHHHHHHHHHTTEEEST-SGGGEEEEE.....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.......EEHHHHHHHHHHHH CS
  Pkinase_Tyr 110 lqvAkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.......ftsksDvWsfGvll 195
                   q+   ++y++++k+vHr++   N+Ll+e     n    +  f L++++   ++  ++ ++  ++++++pE l+ ++       +  ++D+++ Gv++
   EFC35774.1 568 SQIIGTLQYMNKHKIVHRNIKPHNILLREwdpseNIDTVLIGFRLSKSV---SDSASDIQQAGSLQFIPPELLDISEeleentaMFASADIFALGVTC 662
                  ****************************988876444445569999999...5556667777889999999988777677777788899********* PP

                  HHHHTTSSGT......TTTS.HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 196 wEiftlgesp......ypgl.kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                  + ++t+   +      + ++ ++e+v+++l+++   ++    ++ l el+ + ++ + ++R t+ e++++l
   EFC35774.1 663 YQLLTFDTVTmingliM-KYgNEEKVMNHLRSSIIKNQHYPYSTGLVELVISMLRLNTADRITLDEILDRL 732
                  *****888776777744.444889999999999999999999999******************99998765 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0     0.002       3.5       4      30 ..     111     137 ..     109     138 .. 0.92
   2 !   10.2   0.0   0.00055      0.98       2      30 ..     143     170 ..     142     171 .. 0.91
   3 ?    5.8   0.0     0.015        27       1      29 [.     174     201 ..     174     203 .. 0.93
   4 ?   -1.5   0.0       3.6   6.5e+03       8      23 ..     229     244 ..     226     250 .. 0.84
   5 !   12.8   0.0   7.9e-05      0.14       3      30 ..     262     288 ..     260     289 .. 0.92
   6 ?    5.0   0.0     0.026        47       3      28 ..     296     320 ..     294     323 .. 0.87
   7 ?   -2.6   0.1       8.2   1.5e+04      23      31 .]     336     344 ..     335     344 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.002
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 ++L   +r gn+e+v+++++n+ a +n
  EFC35774.1 111 SLLLKMVREGNYEMVEAMINNREAGIN 137
                 79999***************9999888 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00055
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 G+t+L +A+ s n +++kfL++ +g + n
  EFC35774.1 143 GCTALGVAVDSVNMKMLKFLIR-RGGNTN 170
                 99********************.887765 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.015
       Ank_3   1 nGetpLhlAarsgnleivkfLlenkgadv 29 
                 +G+++L ++++ + ++ + +L++ +ga +
  EFC35774.1 174 YGRSILQYCMERNLIPFASYLIR-MGAKP 201
                 79*********************.99976 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 3.6
       Ank_3   8 lAarsgnleivkfLle 23 
                  A+r  n+e++ +L+ 
  EFC35774.1 229 NALRIRNFERANYLIT 244
                 5899999*******98 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 7.9e-05
       Ank_3   3 etpLhlAarsgnleivkfLlenkgadvn 30 
                 etpL+   +++n+e v++L++ +ga v+
  EFC35774.1 262 ETPLYALSKHNNPEAVEWLIK-HGAQVD 288
                 8********************.899886 PP

  == domain 6  score: 5.0 bits;  conditional E-value: 0.026
       Ank_3   3 etpLhlAarsgnleivkfLlenkgad 28 
                 ++ L +A+ + + ++vk L++ +ga+
  EFC35774.1 296 MNSLQVAIQCKHWNVVKTLIK-NGAN 320
                 567999***************.8987 PP

  == domain 7  score: -2.6 bits;  conditional E-value: 8.2
       Ank_3  23 enkgadvna 31 
                 +++g+d+na
  EFC35774.1 336 KHNGIDLNA 344
                 689****96 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.2   4.2e-05     0.075      17      53 ..     107     147 ..      93     150 .. 0.80
   2 !   17.1   0.0   2.9e-06    0.0052       9      45 ..     254     290 ..     249     295 .. 0.89
   3 !   15.2   0.0   1.1e-05      0.02      16      51 ..     295     330 ..     292     331 .. 0.94

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 4.2e-05
       Ank_5  17 n...tpLhvAakygaadvvrlLl.argadlnltdsrGltal 53 
                 n   + L   ++ g+ ++v+ ++ +r+a +n +d +G tal
  EFC35774.1 107 NgkiSLLLKMVREGNYEMVEAMInNREAGINDCDTSGCTAL 147
                 3455778889999***************************9 PP

  == domain 2  score: 17.1 bits;  conditional E-value: 2.9e-06
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLlargadlnlt 45 
                 v++l+++++tpL   +k+++++ v++L+++ga  +l+
  EFC35774.1 254 VDCLNQERETPLYALSKHNNPEAVEWLIKHGAQVDLK 290
                 567888888********************99998876 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 1.1e-05
       Ank_5  16 gntpLhvAakygaadvvrlLlargadlnltdsrGlt 51 
                  ++ L vA+ + +++vv+ L+++ga+  ++d+ Glt
  EFC35774.1 295 NMNSLQVAIQCKHWNVVKTLIKNGANMYIRDEFGLT 330
                 579999****************************98 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   7.8e-05      0.14       9      55 .]     117     163 ..     111     163 .. 0.88
   2 ?   -1.3   0.0       2.1   3.7e+03      39      55 .]     227     243 ..     227     243 .. 0.91
   3 !   10.7   0.0   0.00036      0.65      27      55 .]     254     281 ..     232     281 .. 0.69
   4 !   14.3   0.0   2.5e-05     0.045       3      55 .]     263     315 ..     261     315 .. 0.90
   5 ?    5.4   0.0     0.016        28      15      38 ..     309     331 ..     295     343 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.8e-05
       Ank_4   9 aisgrlelvrlLlekg.adinaqdnrsGetalhiAakrgnveilklLl 55 
                 + +g++e+v+  ++++ a in + + sG tal  A+   n ++lk+L+
  EFC35774.1 117 VREGNYEMVEAMINNReAGINDC-DTSGCTALGVAVDSVNMKMLKFLI 163
                 4589*********996477***9.9*********************98 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 2.1
       Ank_4  39 lhiAakrgnveilklLl 55 
                 +++A+++ n+e++ +L+
  EFC35774.1 227 FINALRIRNFERANYLI 243
                 679************98 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00036
       Ank_4  27 inaqdnrsGetalhiAakrgnveilklLl 55 
                 +++  n + et+l+   k++n+e++++L+
  EFC35774.1 254 VDCL-NQERETPLYALSKHNNPEAVEWLI 281
                 3333.66677******************8 PP

  == domain 4  score: 14.3 bits;  conditional E-value: 2.5e-05
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklLl 55 
                 t+L ++ ++++ e+v++L+ +ga+++    ++ ++ l+ A++  + +++k L+
  EFC35774.1 263 TPLYALSKHNNPEAVEWLIKHGAQVDLKVMDRNMNSLQVAIQCKHWNVVKTLI 315
                 78988899****************999977889999***99999999999887 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.016
       Ank_4  15 elvrlLlekgadinaqdnrsGeta 38 
                  +v+ L+ +ga+ + + ++ G+t+
  EFC35774.1 309 NVVKTLIKNGANMYIR-DEFGLTC 331
                 689*************.*****98 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0      0.08   1.4e+02       2      28 ..     143     170 ..     142     171 .. 0.82
   2 !    7.7   0.0    0.0029       5.2       4      29 ..     263     289 ..     261     290 .. 0.87
   3 !   10.2   0.0   0.00046      0.82       8      31 ..     301     325 ..     298     326 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.08
                 SBBHHHHHH...HHTTHHHHHHHH.TTTSTT CS
         Ank   2 GnTPLHlAa...tngkkriiklLL.hGAnln 28 
                 G+T+L +A+   + +   ++k+L+ +G n n
  EFC35774.1 143 GCTALGVAVdsvNMK---MLKFLIrRGGNTN 170
                 9******99887667...******7776766 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0029
                 BHHHHHHHHTTHHHHHHHH.TTTSTTC CS
         Ank   4 TPLHlAatngkkriiklLL.hGAnlna 29 
                 TPL   +  ++++ +++L+ hGA +++
  EFC35774.1 263 TPLYALSKHNNPEAVEWLIkHGAQVDL 289
                 99996699999***********98775 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00046
                 HHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   8 lAatngkkriiklLL.hGAnlnald 31 
                 +A+++++++++k L+ +GAn  ++d
  EFC35774.1 301 VAIQCKHWNVVKTLIkNGANMYIRD 325
                 69999**********99***98887 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   7.8e-07    0.0014     306     386 ..     560     637 ..     552     646 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 7.8e-07
  Pkinase_fungal 306 kellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievl 386
                     +++++ ++  I g  + ++k +i+Hr i  +Nil+ + +  ++   +Li + l k++sd  s +++ ++ G l+F+  e+l
      EFC35774.1 560 EAVIKKFISQIIGTLQYMNKHKIVHRNIKPHNILLREWDPSENIDTVLIGFRLSKSVSD--S-ASDIQQAGSLQFIPPELL 637
                     5667778888888888899*****************9999999***************6..3.334689999999977766 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.95   1.7e+03      87     115 ..     235     264 ..     220     283 .. 0.75
   2 !   16.1   0.0     3e-06    0.0053     103     167 ..     546     611 ..     513     625 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.95
         Kdo  87 gleyrAlllterlegaqdLedllakwae.l 115
                 ++e+   l+t++l++ + ++d+l++ +e +
  EFC35774.1 235 NFERANYLITKNLKHNILIVDCLNQEREtP 264
                 455777899*******99999999977652 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 3e-06
         Kdo 103 qdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqee.eeeaeiwliDld 167
                  +Le l+++  +l+e++ ++ + ++  + + +++ ++ H+ + ++nill++ + +e++  +li + 
  EFC35774.1 546 GSLESLIKQKVVLKEAVIKKFISQIIGTLQYMNKHKIVHRNIKPHNILLREWDpSENIDTVLIGFR 611
                 5899999997779**************************************999999999999875 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       1.4   2.5e+03      64     137 ..     231     302 ..     228     315 .. 0.66
   2 ?   13.8   0.0   1.4e-05     0.026     144     285 ..     562     719 ..     532     722 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.4
  Kinase-like  64 lairllrgknpeqAkdhlrlllpfdlvkiqkkkpfiqlkskesiywvvnallllpaasvdleilnkvlqkrset 137
                  l+ir++   n    k+    +l +d  + ++  p+  l+++++  +v    l+   a+vdl+++   +++ ++ 
   EFC35774.1 231 LRIRNFERANYLITKNLKHNILIVDCLNQERETPLYALSKHNNPEAV--EWLIKHGAQVDLKVMDRNMNSLQVA 302
                  55555555555555555666666666677777777777777777744..5677888888888888888877765 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 1.4e-05
  Kinase-like 144 iarlllTlqlirlaanLqakglvhgkftvdnlllde.....kgglmlggftaLvragtkvvlseve....kgfaPpEllgsrggytrknktkmthkld 232
                  + ++ +  q+i   +++ ++ +vh +++++n+ll e     +   +l gf  L +       s ++      f PpEll        +++t m  + d
   EFC35774.1 562 VIKKFI-SQIIGTLQYMNKHKIVHRNIKPHNILLREwdpseNIDTVLIGFR-LSKSVSDSA-SDIQqagsLQFIPPELLDISEE--LEENTAMFASAD 654
                  445555.689999*********************86222224556777775.444333333.55554444679******99777..567999999*** PP

  Kinase-like 233 aWqlGlviyriwclk...lPltlateeakeew........kfklck.kipekvkaLlkkfLqlsq 285
                    +lG++ y +  ++   + ++l+ + ++ee         + k  + + +  +  L++ +L+l+ 
   EFC35774.1 655 IFALGVTCYQLLTFDtvtMINGLIMKYGNEEKvmnhlrssIIKNQHyPYSTGLVELVISMLRLNT 719
                  *********99876511134455555555554555555543333333555555556666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (736 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       850  (0.0474092); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.74u 0.32s 00:00:01.06 Elapsed: 00:00:00.52
# Mc/sec: 4283.55
//
Query:       EFC35775.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-82  277.2   0.0    1.6e-82  277.0   0.0    1.0  1  Aldo_ket_red  Aldo/keto reductase family


Domain annotation for each model (and alignments):
>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  277.0   0.0   9.2e-87   1.6e-82       1     292 [.      15     342 ..      15     344 .. 0.93

  Alignments for each domain:
  == domain 1  score: 277.0 bits;  conditional E-value: 9.2e-87
                   .EEEE-SSS-ST.....TS-HHHHHHHHHHHHHTT--EEE--TT-TTTHHHHHHHHHHHH-TTTGGG-EEEEEE...............--SSSTTS CS
  Aldo_ket_red   1 elglGtwqlgsk....eeiskeealellrraleaGinffDtAevYgkgqseellGealkksrkkreeviiatKv...............dlrdaeik 78 
                   +++lG +++gs+    ++ +++e+  +l++a e GinffDtA++Y +g+se++lG+++ +++ +reev+iatKv                ++++ + 
    EFC35775.1  15 KICLGCMSFGSPkwfdWVLEEPESMIILKKAWELGINFFDTANLYSNGESERILGKFIRENNIPREEVVIATKVfgpvdksgeqrylplSDDKKVNT 111
                   69***************************************************************************************99****** PP

                   SSS-HHHHHHHHHHHHHHHT-S-EEEEEE-S--TTS-.HHHHHHHHHHHHHTTSEEEEEEES--HHHHHHH....HHTTT--EEEEE-B-BTT-HHH CS
  Aldo_ket_red  79 sglskeniresleeslkrLgtdyvDllllHrpdpslpsieevldaleelvkeGkiraiGvSnfsveqleka....kkkkkvkivavqveynllrele 171
                    gls+++i++++eesl+rLgtdy+Dl+ +Hr+dp++p iee++++l++lvk+Gk+r+iG S   ++q  ka     kk+ +k+v+ q+ y+ll ++e
    EFC35775.1 112 HGLSRKHIMHAVEESLERLGTDYIDLYIIHRWDPDTP-IEETMETLHDLVKSGKVRYIGASLMFAWQFAKAqhyaDKKGLTKFVSMQNLYHLLYREE 207
                   *************************************.***********************777777777777799********************* PP

                   HTTHHHHHHHTT-EEEEBSTTGGGTTGTTTS...S---SSSCCC-------...........TS-HHHHHHHHHHHHHHHHTT--HHHHHHHHHTTS CS
  Aldo_ket_red 172 eegllelckkkgvpliaysplggGlltgkyq...seedkedkeprkdlkrd...........ertsknldaaeelselakehgvslaqlalryalsq 254
                   e+ ++++c ++gv l +yspl++G+l +  +   se+  +d+++++++kr             +t++  + ++++sela++++vs+aq+a++++l++
    EFC35775.1 208 ERDMIPMCLDQGVSLTPYSPLAKGILARAHEfvnSEKTSNDEDEDEKSKRAnsdfiqkqfqeTITEGDKENLRRVSELANKKNVSPAQIAIAWLLKK 304
                   **************************98654111344444444444444448899******999********************************* PP

                   TT-SEEEE--SSHHHHHHHHGGGG----HHHHHHHHHH CS
  Aldo_ket_red 255 pavgivipgasnieqlednldalelklseeevaeldel 292
                   p+v+++i+ga++++ +e +++al+++l++eev++lde 
    EFC35775.1 305 PGVTSPIVGATKVSNIESSIAALDIELTTEEVKYLDES 342
                   ***********************************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       819  (0.0456802); expected 358.6 (0.02)
Passed bias filter:                      539  (0.030063); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2286.90
//
Query:       EFC35776.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0044   16.2   2.6     0.0045   16.2   2.6    1.1  1  MMS19_C   RNAPII transcription regulator C-terminal
  ------ inclusion threshold ------
       0.14   13.0   7.1       0.63   11.0   7.1    2.0  1  DUF2624   Protein of unknown function (DUF2624)


Domain annotation for each model (and alignments):
>> MMS19_C  RNAPII transcription regulator C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   2.6     5e-07    0.0045      63     179 ..       3     111 ..       1     164 [. 0.74

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 5e-07
     MMS19_C  63 ailstllkllekkq.tdlekeellnsyydrivprlltlvvsaastss....siltddrllevlgriinlivrslssskqqevleevvalfltgdaskkf 156
                 ai +++ +ll++   ++l   ++  +y++ i+ ++ +++++    ++      ++d  + +++++iin+ + +ls  + ++ ++++ +++ t  +++  
  EFC35776.1   3 AISQNISTLLNNIPfNQL--FQNSLQYSQPIINQMAQQFTNQQVIETvkssLKQNDIDFSTIVSEIINATITKLSEPQTKQEINQILNYYATHATDS-- 97 
                 567778888888775333..24555677777777777766655544455547888889999******************************998888.. PP

     MMS19_C 157 eplsesasesqkqliilftaila 179
                  p         + l+i f ++l 
  EFC35776.1  98 IP---------TWLLIFFGSVLV 111
                 22.........223344444444 PP

>> DUF2624  Protein of unknown function (DUF2624)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   7.1   7.1e-05      0.63       1      82 [.       1      90 [.       1      91 [. 0.75

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 7.1e-05
     DUF2624  1 MniiqqlVnqklnsiTaeellkyakqygveltksqAek.....ivkilre..kkidifnkeerkkllk.elakitspqtakkvneLlkqf 82
                M+ i q +   ln+i  + l++ + qy  ++ ++ A++     +++++++  k++di   + ++++++  + k+ +pqt +++n++l+ +
  EFC35776.1  1 MSAISQNISTLLNNIPFNQLFQNSLQYSQPIINQMAQQftnqqVIETVKSslKQNDIDFSTIVSEIINaTITKLSEPQTKQEINQILNYY 90
                665667788999*****************99998887522222555555433455665588888888736899999***********977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1637  (0.0913046); expected 358.6 (0.02)
Passed bias filter:                      566  (0.031569); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.55
# Mc/sec: 959.82
//
Query:       EFC35777.1  [L=822]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (822 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2242  (0.125049); expected 358.6 (0.02)
Passed bias filter:                      648  (0.0361426); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.89u 0.30s 00:00:01.19 Elapsed: 00:00:00.50
# Mc/sec: 4920.19
//
Query:       EFC35778.1  [L=257]
Description: calponin homology domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-12   48.1   0.0    2.2e-12   47.1   0.0    1.6  1  CH          Calponin homology (CH) domain
     0.0092   15.8   0.0      0.024   14.5   0.0    1.7  1  CAMSAP_CH   CAMSAP CH domain
  ------ inclusion threshold ------
       0.13   12.4   1.2        8.3    6.7   0.0    3.1  3  SRI         SRI (Set2 Rpb1 interacting) domain
        2.9    8.4   4.9        3.3    8.2   0.2    3.1  3  Bombolitin  Bombolitin family


Domain annotation for each model (and alignments):
>> CH  Calponin homology (CH) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.1   0.0   4.9e-16   2.2e-12       3      81 ..      16      96 ..      14     124 .. 0.92

  Alignments for each domain:
  == domain 1  score: 47.1 bits;  conditional E-value: 4.9e-16
                HHHHHHHHHHHHHTTSTTSSTTSCHHHHHTTSHHHHHHHHHHSTTTSSGGGSTTT....HHHHHHHHHHHHHHHHHHTTCHTT CS
          CH  3 qkkellrWinshleeagpkvkvedfeedlrDGvlLckLlnklapglvdkkklnks....efkkleNinlaldvaekklgvpkv 81
                +++e+ rWi++ ++e+ p   + +f ++lrDG++L+kL + +ap +++k + +ks    ef +++Ni++++++++ k+++p+ 
  EFC35778.1 16 RQEEAKRWIEELIQESLPPG-TANFGDNLRDGIALAKLGKIFAPTAIKKINTPKSgsvlEFMAVDNISQFFEACK-KVNFPDH 96
                6899*********9986655.6******************************999*****************777.9999875 PP

>> CAMSAP_CH  CAMSAP CH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   5.4e-06     0.024      15      67 ..      38      90 ..      29      97 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 5.4e-06
   CAMSAP_CH 15 dllrdlsdGvaLaalihfYcPqliklediclkesmsl..adslyNiqllqefcer 67
                ++  +l+dG+aLa+l + + P++ik   i+  +s s+  +  ++Ni++++e+c++
  EFC35778.1 38 NFGDNLRDGIALAKLGKIFAPTAIKK--INTPKSGSVleFMAVDNISQFFEACKK 90
                666789******************55..7766776652266789********986 PP

>> SRI  SRI (Set2 Rpb1 interacting) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.027   1.2e+02      10      32 ..     114     136 ..     112     145 .. 0.83
   2 ?    6.7   0.0    0.0018       8.3       9      43 ..     182     217 ..     178     235 .. 0.90
   3 ?   -1.4   0.1      0.62   2.8e+03      30      39 ..     248     257 .]     239     257 .] 0.75

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.027
         SRI  10 kelakvVvnvlnkYrkklkkedf 32 
                 ++l+ v+v++ +kY k+++ + +
  EFC35778.1 114 NKLSDVIVKLSEKYYKEISPDIL 136
                 68999***********9987755 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0018
         SRI   9 kkelakvVvnvlnkYrkk.lkkedfKklakeltkkl 43 
                 k+++ ++ +  ++ Y+ k l+ ++fKk+  ++t  l
  EFC35778.1 182 KNTFTNLLITSISVYERKvLDCDKFKKVLTHITDRL 217
                 78999999********************99999876 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.62
         SRI  30 edfKklakel 39 
                 e++Kkl+k+l
  EFC35778.1 248 EELKKLTKKL 257
                 7888888886 PP

>> Bombolitin  Bombolitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.2   0.00074       3.3       7      15 ..      49      57 ..      47      58 .. 0.91
   2 ?   -3.3   0.1       3.3   1.5e+04       2      10 ..     115     123 ..     115     123 .. 0.79
   3 ?    0.7   0.1      0.18   7.9e+02      10      17 .]     206     213 ..     204     213 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00074
  Bombolitin  7 LAKLGKVLA 15
                LAKLGK+ A
  EFC35778.1 49 LAKLGKIFA 57
                9*****987 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.3
  Bombolitin   2 KItDILAKL 10 
                 K  D+  KL
  EFC35778.1 115 KLSDVIVKL 123
                 678998887 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.18
  Bombolitin  10 LGKVLAHV 17 
                   KVL H+
  EFC35778.1 206 FKKVLTHI 213
                 55*****6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       695  (0.038764); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 1714.71
//
Query:       EFC35779.1  [L=893]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      3e-22   79.3   0.2    6.5e-22   78.1   0.2    1.5  1  Pkinase        Protein kinase domain
    2.4e-10   40.4   0.5    0.00072   19.4   0.0    2.8  2  Peptidase_C97  PPPDE putative peptidase domain
    1.5e-09   37.5   0.0    2.8e-09   36.7   0.0    1.3  1  Pkinase_Tyr    Protein tyrosine kinase
    4.4e-05   23.8   2.2       0.54   10.6   0.2    3.4  3  LRAT           Lecithin retinol acyltransferase
  ------ inclusion threshold ------
      0.013   14.9   0.0      0.024   14.0   0.0    1.3  1  Kdo            Lipopolysaccharide kinase (Kdo/WaaP) family
        0.1   13.0   0.3        1.4    9.3   0.1    2.3  2  DUF778         Protein of unknown function (DUF778)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.1   0.2   2.2e-25   6.5e-22      46     245 ..      68     269 ..      48     279 .. 0.68

  Alignments for each domain:
  == domain 1  score: 78.1 bits;  conditional E-value: 2.2e-25
                 HHHHHHHHHHS.CTTB--EEEEEEE....SSEEEEEEE--TTEB..HHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE CS
     Pkinase  46 lrEikilkklk.hpnivrlyevfee....kdelylvleyvegge..ladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge 136
                 l+E +  k+ k  ++iv+  e++      + +++l   + ++g+  l+++l+     + ee  ki +qi +gl  lHs++iiH  lKpeNiL+  e+  
  EFC35779.1  68 LTEYECNKHEKiRQQIVNQHEIVPIwdtgDYDMFLKYSISPKGTcnLNEYLTYY-EPNLEESLKIYSQIEKGLLKLHSMNIIHGNLKPENILFFeEDFT 165
                 555555555555555555555443333334445555555555555577777632.23334566899**************************9945555 PP

                 EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCB.SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS- CS
     Pkinase 137 lKitDFGlakelessskltsfvgtseYlAPEvlkeney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseis 234
                 +K+ DF  +   ++    ++f  + eY APEvl ++++ +k++D++slG+il++llt++p+    kg++ +++++++ ++ + + +  +e+++e   + 
  EFC35779.1 166 FKLFDFKYSVLDNQP---SEFRHSNEYTAPEVLLASQIvDKSADLFSLGCILFKLLTRQPLRI--KGETFAQMMIRE-KRRIGVGKYIDETTKEIMGLH 258
                 ******999877664...69*************665555*****************9998866..666656666666.334444444444555544445 PP

                 HHHHHHHHHHT CS
     Pkinase 235 eeakdllkkll 245
                 +++++ lk ll
  EFC35779.1 259 SNLLEHLKALL 269
                 55555555554 PP

>> Peptidase_C97  PPPDE putative peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   2.4e-07   0.00072      70     121 ..     423     477 ..     355     483 .. 0.61
   2 !   18.2   0.1   5.8e-07    0.0017      59     121 ..     684     749 ..     629     752 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.4e-07
                    S-SEEEEEEEE---HHHHHHHHHHHHT...T--GG.G-BTTTB-HHHHHHHHHHHH CS
  Peptidase_C97  70 kpresieigeTevteeevraileelss...eytgd.kYnLiskNCnhFtdelvdfL 121
                    k   +i+ige     e+v++  ++l +   +y+g+ +Y+ ++ NC+hFt e++  L
     EFC35779.1 423 KTLAIIDIGEIRG-AENVKQTFRKLTEiicKYNGSvQYHQFKANCQHFTSEVLSAL 477
                    3333345554443.34445555555554436998549***************9887 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 5.8e-07
                    EESTT-STT-.S-SEEEEEEEE---HHHHHHHH..HHHHTT--GG.G-BTTTB-HHHHHHHHHHHH CS
  Peptidase_C97  59 elkpgttsegakpresieigeTevteeevrail..eelsseytgd.kYnLiskNCnhFtdelvdfL 121
                    e+ + +     +    i+ige    ++ ++a++   ++s +y+++ +Y L++ NC+hF  +l++ L
     EFC35779.1 684 ECDSDQKLDTNNTIAAIDIGEIAGADNVKKAFEliTKISCNYNATkNYSLLGANCQHFVSDLLEAL 749
                    55555544455566667777777777777776555999999997526**************99877 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.7   0.0   9.3e-13   2.8e-09      87     238 ..     113     255 ..      55     260 .. 0.79

  Alignments for each domain:
  == domain 1  score: 36.7 bits;  conditional E-value: 9.3e-13
                  BHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETT.EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.E CS
  Pkinase_Tyr  87 dLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenk.vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.f 182
                  +L+++L+     + +l++ l++  q+ kG+  L+s++++H +l   N+L  e++ + k+ Df  +         ++ +e + + +++apE+l +++ +
   EFC35779.1 113 NLNEYLTYY---EPNLEESLKIYSQIEKGLLKLHSMNIIHGNLKPENILFFEEDfTFKLFDFKYSVLD------NQPSEFRHSNEYTAPEVLLASQiV 201
                  677777766...788999*******************************87655499*****887755......45566777889******9888746 PP

                  EHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHH.HTTEES-BBTTSBHHHHHHH CS
  Pkinase_Tyr 183 tsksDvWsfGvllwEiftlgespypglkneevlekl.kegkrlekpekcpeelyelm 238
                   +++D +s G +l+ ++t  ++p++ +k e++++++ +e++r+   +++ e+ +e+m
   EFC35779.1 202 DKSADLFSLGCILFKLLT--RQPLR-IKGETFAQMMiREKRRIGVGKYIDETTKEIM 255
                  7778*************9..88885.5566666655488888888888888888888 PP

>> LRAT  Lecithin retinol acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   0.00019      0.56      96     121 ..     448     473 ..     399     478 .. 0.71
   2 ?   -0.3   0.0      0.42   1.2e+03       7      44 ..     652     690 ..     647     717 .. 0.63
   3 !   10.6   0.2   0.00018      0.54      93     120 ..     717     744 ..     689     749 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00019
                 HHHHHHTT-E-SCGHHCHHHHHHHHH CS
        LRAT  96 qrAeelvGeveYsllsnNCEhFvtyc 121
                 +   + +G+v+Y+ ++ NC hF +++
  EFC35779.1 448 EIICKYNGSVQYHQFKANCQHFTSEV 473
                 4445689***************9875 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.42
                 -EEEEE-SSSEEEEEEEETTEEEEEE-SB...........-G CS
        LRAT   7 dllevsRtlyeHhgiyvGdgkVvHltpes....tsekskiek 44 
                  +l+v+ +   H gi +G+ k+  + ++         ++ +k
  EFC35779.1 652 AILNVNNYGVVHTGILIGEWKIEWYDNSLvrveC---DSDQK 690
                 56889999999*******9998888755553321...22233 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00018
                 HHHHHHHHHTT-E-SCGHHCHHHHHHHH CS
        LRAT  93 eviqrAeelvGeveYsllsnNCEhFvty 120
                  + + + + + + +Ysll  NC hFv+ 
  EFC35779.1 717 LITKISCNYNATKNYSLLGANCQHFVSD 744
                 5556666677889*************86 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0     8e-06     0.024     103     172 ..     112     177 ..     109     188 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 8e-06
         Kdo 103 qdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldkarlr 172
                  +L+++l+ + e++ e   +++ ++ +   klh++++ H+ l + nil+ +e+   +++ l D+  + l 
  EFC35779.1 112 CNLNEYLT-YYEPNLEESLKIYSQIEKGLLKLHSMNIIHGNLKPENILFFEED---FTFKLFDFKYSVLD 177
                 56777777.3556666667899999999*********************9997...9******9877665 PP

>> DUF778  Protein of unknown function (DUF778)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.14   4.3e+02     145     169 ..     448     480 ..     372     547 .. 0.81
   2 ?    9.3   0.1   0.00047       1.4     126     167 ..     707     750 ..     673     789 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.14
      DUF778 145 g........eeynLltanchsfvalaLnklrye 169
                 +         +y  + anc+ f +  L  l+ +
  EFC35779.1 448 EiickyngsVQYHQFKANCQHFTSEVLSALNLQ 480
                 24555555579999********99999877765 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00047
      DUF778 126 dadgirsaPdl.sssseef.qgeeynLltanchsfvalaLnklr 167
                  ad +++a +l ++ s ++  +++y+Ll anc+ fv+  L+ l+
  EFC35779.1 707 GADNVKKAFELiTKISCNYnATKNYSLLGANCQHFVSDLLEALN 750
                 4688888888624566788899***************9998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (893 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       559  (0.0311785); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.75u 0.35s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 5030.52
//
Query:       EFC35780.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.13   12.3   4.0       0.16   12.0   4.0    1.1  1  p53-inducible11  Tumour protein p53-inducible protein 11


Domain annotation for each model (and alignments):
>> p53-inducible11  Tumour protein p53-inducible protein 11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   4.0   8.9e-06      0.16      58     168 ..      17     129 ..       4     141 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 8.9e-06
  p53-inducible11  58 llsavvf.talallalvfPdtlvevvfseeladtkisilalrlyGgallalalilWnalttaek..viirwtLllealylaiqvlvtavtlves 148
                       l+ +++   +a  al+fP+++ + +f  ++ ++  s++a+ + G   +a+ +i   +l  + +  ++  + L+ + lyl + +l     ++ +
       EFC35780.1  17 YLANIMVaGYVACFALFFPQQAQSELFYGNSLTDDGSTIAVMIVGCHWMAIVIISMLGLFFPLQcsIVFVHQLIYKSLYLLLVALPA---MWMK 107
                      444444415699***************999999999999*******99999999888777665411444566777777766554433...3333 PP

  p53-inducible11 149 esl..staavllllsrllalvi 168
                       ++  ++++++ +   ll lvi
       EFC35780.1 108 REVpqPMTTLFAIWVLLLPLVI 129
                      3330034445555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       713  (0.039768); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 945.12
//
Query:       EFC35781.1  [L=741]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (741 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       904  (0.0504211); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.28s 00:00:00.94 Elapsed: 00:00:00.45
# Mc/sec: 4972.83
//
Query:       EFC35782.1  [L=159]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-11   43.2   1.2      9e-11   42.1   1.2    1.5  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.076   13.2   0.1       0.14   12.3   0.1    1.4  1  DicB      DicB protein


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.1   1.2     1e-14     9e-11       2     112 ..       7     142 ..       6     145 .. 0.89

  Alignments for each domain:
  == domain 1  score: 42.1 bits;  conditional E-value: 1e-14
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHH..HHHHHHHCSS............... CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklr..eelekrleke............... 83 
                 ++++l +++   lF +F e+ f+ e +  w a+e+fk+ k+++++ + +++I n+y+  ++p elni++k +   e+ k +e                 
  EFC35782.1   7 IRKILLNEKWNDLFLKFSEKCFACEDVMMWNAIEKFKAIKSEKQRRELFYNICNTYIRLGAPLELNISRKDFgiPEIMKTFEALresairgssgspsgt 105
                 5789999*************************************************************98651133444444336778*********** PP

                 .........STTTTTTHHHHHHHHHHHHHHHHHHHHTS CS
         RGS  84 .........qpsrklfeeaqeevfellekdsypkFlks 112
                            ++++f+++q+++   +  d y++F+ s
  EFC35782.1 106 dspkkrtifAITSEMFDRIQTACEHNML-DNYTRFQAS 142
                 **************************95.789999987 PP

>> DicB  DicB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   1.6e-05      0.14      11      46 ..      24      60 ..      20      69 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.6e-05
        DicB 11 seGcfei.GvtisnPvftedainkrkqerellnkici 46
                se cf    v + n +    ai   kq rel+  ic 
  EFC35782.1 24 SEKCFACeDVMMWNAIEKFKAIKSEKQRRELFYNICN 60
                8999987359999***999*****************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       749  (0.0417759); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1051.78
//
Query:       EFC35783.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
          9    6.7  11.4       0.34   11.3   3.9    2.2  3  DUF2663   Protein of unknown function (DUF2663)


Domain annotation for each model (and alignments):
>> DUF2663  Protein of unknown function (DUF2663)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.4      0.17   3.1e+03      27      49 ..      68      97 ..      53     124 .. 0.46
   2 ?   -1.0   0.3      0.12   2.1e+03       9      64 ..      79     137 ..      72     149 .. 0.59
   3 ?   11.3   3.9   1.9e-05      0.34       5      69 ..     255     320 ..     252     329 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.17
     DUF2663 27 llvlllfliyvlik.......ssslsslls 49
                llv++ +l+y l k       ++++ ++l+
  EFC35783.1 68 LLVSVGGLVYKLRKlhilqkeHKQVVNYLQ 97
                444444444444444444222233333333 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.12
     DUF2663   9 Kkkweklekrlll.lsllallvlllfliyvlik..ssslssllsallessvlllllllv 64 
                  +k   l+k++++ ++ l ++   +++++ +i   ++++  + ++l++ +++  +++ +
  EFC35783.1  79 LRKLHILQKEHKQvVNYLQVARNPALMVMGAIIgwTYTFVLMTRVLIGRKIYPCFIFSL 137
                 55666666665541344555555555555544455666677777777777776666655 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 1.9e-05
     DUF2663   5 likrKkkweklekrllllsllallvlllfliyvliksssl.ssllsallessvlllllllvallyv 69 
                 l + K kwe +ekrl++l+ + + + ++f++y li++ ++  +++ a+++   ++ + ++  +ly+
  EFC35783.1 255 LFRNKTKWEIFEKRLFTLFRFIVGTKFIFVVYGLIVALHImIYYIIAIVDYFRSICIYFICSFLYF 320
                 5678*****************************999544415566666666555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1244  (0.0693848); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2279.37
//
Query:       EFC35784.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       890  (0.0496402); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 977.31
//
Query:       EFC35785.1  [L=823]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0045   16.8   3.8      0.014   15.2   3.8    1.8  1  Pox_Ag35  Pox virus Ag35 surface protein


Domain annotation for each model (and alignments):
>> Pox_Ag35  Pox virus Ag35 surface protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   3.8   7.6e-07     0.014      53     132 ..     547     630 ..     536     636 .. 0.48

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 7.6e-07
    Pox_Ag35  53 kkkrattprkkpakkekkkkeeekeeaaeee........eledseedeenendedeseesvqaeeeksnesteddadeldeSdLkvat 132
                  ++r+ tp+k++++++    +    ++  ++         ++++++d +n+nd d++++  + ++ +s+++    +++  e + ++at
  EFC35785.1 547 LRQRIVTPKKNTTTSSTSAPSYATARKRAKKtssdssesRVDNNNNDADNNNDADNNNDIGSDNDVSSDNN----TNNNIEAEVELAT 630
                 57899999999555443333222222222230111111144445555555555555554444444333333....3333345555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (823 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1837  (0.10246); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.32s 00:00:01.12 Elapsed: 00:00:00.49
# Mc/sec: 5031.00
//
Query:       EFC35786.1  [L=105]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      236  (0.013163); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.43
# Mc/sec: 726.63
//
Query:       EFC35787.1  [L=526]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.56    9.0   2.4       0.33    9.7   0.1    1.8  2  Amnionless  Amnionless


Domain annotation for each model (and alignments):
>> Amnionless  Amnionless
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.5      0.21   3.8e+03     348     371 ..     235     257 ..     227     265 .. 0.58
   2 ?    9.7   0.1   1.8e-05      0.33     342     389 ..     357     411 ..     328     445 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 0.21
  Amnionless 348 glvlgivfglvlllllllilllll 371
                  l++  ++g+++l ++ +i+++ +
  EFC35787.1 235 VLIVISLVGMIVLCCFSAIYTF-I 257
                 3455556666555555555443.3 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 1.8e-05
  Amnionless 342 apgesaglvlgivfglvlllllllillllllrrkgvlrlpqllksps.......r 389
                 ++ +  ++++giv+gl l+  ++ +l+  ++ r+++ r+++++ksps        
  EFC35787.1 357 EDMMGIAMFFGIVLGLSLIFSIIGVLIGDIYTRSIMRRIRSIMKSPSavvghmaS 411
                 4567789999999999888888888777778887777*********654322220 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (526 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1569  (0.0875119); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.76u 0.35s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 3100.73
//
Query:       EFC35788.1  [L=124]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (124 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1510  (0.0842211); expected 358.6 (0.02)
Passed bias filter:                      211  (0.0117686); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.48
# Mc/sec: 770.91
//
Query:       EFC35789.1  [L=692]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (692 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1220  (0.0680462); expected 358.6 (0.02)
Passed bias filter:                      228  (0.0127168); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.50
# Mc/sec: 4153.36
//
Query:       EFC35790.1  [L=206]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-65  221.0   0.5    2.6e-65  220.8   0.5    1.0  1  DUF4419   Domain of unknown function (DUF4419)
  ------ inclusion threshold ------
        2.9    8.9   5.7         12    7.0   4.1    2.3  2  WD40      WD domain, G-beta repeat


Domain annotation for each model (and alignments):
>> DUF4419  Domain of unknown function (DUF4419)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  220.8   0.5   2.9e-69   2.6e-65      92     302 .]       1     200 [.       1     200 [. 0.94

  Alignments for each domain:
  == domain 1  score: 220.8 bits;  conditional E-value: 2.9e-69
     DUF4419  92 lpdFsTttetdkvvaavllmatlkkyfeykvsllCGiPsvtLlGekeDWekllerlekLkefg...eelkewaklLrpildrfvesfdepdseenkeFW 187
                 +pdF+Tttetd+++ av+lma++k+yf+y +sl+C +P+vtLlGe eDW++++er+++L ef+   + +k+w+klL p+ld+fves++  +++ +ke+W
  EFC35790.1   1 MPDFTTTTETDRMIGAVVLMAAMKNYFDYMFSLCCNLPNVTLLGEVEDWVSIRERANRLLEFDtkeNCMKKWSKLLFPVLDKFVESIK--GNP-DKEWW 96 
                 89************************************************************555599********************..656.799** PP

     DUF4419 188 nkivkeeseegsgeselsGWitaFcvydkdgkvleeekkeeeeeeseeeealvldgveypeidtddipsglasvpvkldedngkeyelelvaGsvGvkv 286
                 n+++++ ++ gsg+s+lsGWit+Fcv++++g++ +++k+ +   e++         +e+p id+d ip+g++svp+ +d dng+ y++e++aG+++++ 
  EFC35790.1  97 NRVAHHCGG-GSGPSYLSGWITSFCVFSDKGHWVGDQKSVNIWGETT--------TMEWPIIDQDVIPRGYVSVPIVVD-DNGTIYDTEMFAGHMSTEL 185
                 ****99998.9************************999888776543........468********************9.999**************** PP

     DUF4419 287 sseeedtlqpvsgWal 302
                  +++ +tl+p ++Wal
  EFC35790.1 186 LEDG-KTLKPRADWAL 200
                 ***9.8********96 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1     0.096   8.6e+02      12      25 ..      83      99 ..      77     108 .. 0.75
   2 ?    7.0   4.1    0.0013        12      12      37 ..     111     138 ..      98     138 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.096
                SEEEEEEETTSSE...E CS
        WD40 12 svtslafspdgaw...l 25
                +v s++ +pd+ w   +
  EFC35790.1 83 FVESIKGNPDKEWwnrV 99
                58999*******96663 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0013
                 S....EEEEE.EETTSSEEEEEETTSEEEEE CS
        WD40  12 s....vtsla.fspdgawlasGsdDgtvriW 37 
                      +ts++ fs+ g+w+  G+  ++v iW
  EFC35790.1 111 YlsgwITSFCvFSDKGHWV--GD-QKSVNIW 138
                 14456999999*******6..99.******* PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (206 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       504  (0.0281109); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1246.94
//
Query:       EFC35791.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.2e-30  102.6  11.4    7.5e-08   32.8   0.7    5.1  5  Sel1      Sel1 repeat
  ------ inclusion threshold ------
      0.086   12.9   3.5         16    5.8   0.0    3.5  4  TPR_7     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.0   3.4e-05       0.3      18      37 ..       7      26 ..       1      27 [. 0.86
   2 !   32.8   0.7   8.4e-12   7.5e-08       4      38 .]      31      63 ..      28      63 .. 0.94
   3 !   20.6   0.1   5.6e-08   0.00051       3      38 .]      66      99 ..      64      99 .. 0.89
   4 !   15.8   0.0   1.9e-06     0.017       8      35 ..     108     133 ..     107     135 .. 0.91
   5 !   25.0   1.0   2.4e-09   2.2e-05       3      38 .]     140     173 ..     139     173 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.4e-05
        Sel1 18 gvpkDpekAiewyekAAeqG 37
                g+ +D +kA+e++e +Ae+G
  EFC35791.1  7 GLNQDLHKAFEYFENSAELG 26
                5679**************99 PP

  == domain 2  score: 32.8 bits;  conditional E-value: 8.4e-12
        Sel1  4 myrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                 +r++  y+y+ G gv+ D++kA+e+y kAAe+Gd
  EFC35791.1 31 IFRVA--YAYHSGEGVKLDYSKAMEYYLKAAEMGD 63
                5899*..***************************7 PP

  == domain 3  score: 20.6 bits;  conditional E-value: 5.6e-08
        Sel1  3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                A ++ +   +yl+G+gv ++ + A++w + A eqG+
  EFC35791.1 66 AKNNIA--DMYLKGQGVQQNFQTALKWIKEAMEQGN 99
                667899..666**********************997 PP

  == domain 4  score: 15.8 bits;  conditional E-value: 1.9e-06
        Sel1   8 GmfylylnGlgvpkDpekAiewyekAAe 35 
                 G  ++++nG gv+kD++ A+ +++++ +
  EFC35791.1 108 G--EMLFNGNGVEKDYNTAFDHFKRSSD 133
                 8..888******************9875 PP

  == domain 5  score: 25.0 bits;  conditional E-value: 2.4e-09
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 A + LG   +y++G g +kD++kA+ +y + A+ Gd
  EFC35791.1 140 AHFLLG--RMYEYGWGCKKDINKAYVLYLRGAKDGD 173
                 899***..666*********************9986 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.27   2.4e+03      14      27 ..      11      24 ..       9      26 .. 0.75
   2 ?    5.6   0.2    0.0021        18      14      28 ..      47      61 ..      47      67 .. 0.83
   3 ?    5.8   0.0    0.0018        16       3      29 ..      68      96 ..      68     101 .. 0.91
   4 ?   -2.3   0.0      0.69   6.2e+03       1      10 [.     140     149 ..     140     150 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.27
       TPR_7 14 dyeeAielyeqsLa 27
                d  +A e++e s +
  EFC35791.1 11 DLHKAFEYFENSAE 24
                67788899998765 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0021
       TPR_7 14 dyeeAielyeqsLal 28
                dy++A e+y ++ ++
  EFC35791.1 47 DYSKAMEYYLKAAEM 61
                8**********7665 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0018
       TPR_7  3 lnLarlysr....lGdyeeAielyeqsLalt 29
                +n+a++y +    ++++++A++  ++  a++
  EFC35791.1 68 NNIADMYLKgqgvQQNFQTALKWIKE--AME 96
                79********************9999..665 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 0.69
       TPR_7   1 aLlnLarlys 10 
                 a++ L+r+y+
  EFC35791.1 140 AHFLLGRMYE 149
                 5788999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 1495.14
//
Query:       EFC35792.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-09   36.0   0.0    7.8e-09   35.3   0.0    1.3  1  HELP      HELP motif
    5.2e-08   33.4   0.2    0.00011   22.9   0.1    3.3  3  WD40      WD domain, G-beta repeat


Domain annotation for each model (and alignments):
>> HELP  HELP motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.3   0.0   8.8e-13   7.8e-09      13      74 .]      15      76 ..       7      76 .. 0.88

  Alignments for each domain:
  == domain 1  score: 35.3 bits;  conditional E-value: 8.8e-13
        HELP 13 tlyiPsklenldakkkselPdekLkLewvyGYrgkdcrnnlfll.ptgeivYfvAavvvlynv 74
                t ++P  +++  ++++ e+P  kLk+e+++G+  k c  n+f + +++ +vY +A+ +v++nv
  EFC35792.1 15 TTHPPP-NSSGLMESNPEKPLSKLKIEYIHGCSKKGCYGNVFHVdDEQHLVYPAAGCGVVLNV 76
                556665.4677779999*************************9978999************96 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.1   1.3e-08   0.00011       3      38 .]      80     118 ..      78     118 .. 0.91
   2 !    5.5   0.0    0.0039        35      12      27 ..     139     155 ..     126     168 .. 0.71
   3 ?    1.2   0.0     0.087   7.8e+02       1      19 [.     173     192 ..     173     194 .] 0.81

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 1.3e-08
                 EEEEEESS.SSEEEEEEETTSSEEEEE..ETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasG..sdDgtvriWd 38 
                 +++++  H ++v +la +p+g+++asG  ++D  ++iWd
  EFC35792.1  80 TQKVFCKHdDDVVALAKHPNGRYFASGqmGKDDMIYIWD 118
                 6788889*77799**************9999*******9 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0039
                 S.EEEEEEETTSSEEEE CS
        WD40  12 s.vtslafspdgawlas 27 
                 + v  ++fs +g++la+
  EFC35792.1 139 GgVLTCCFSTEGSLLAC 155
                 2586777*******985 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.087
                 TEEEEEEESSSS.EEEEEEE CS
        WD40   1 gqclrtltGHss.vtslafs 19 
                 g+cl   +G +  v++l+fs
  EFC35792.1 173 GTCLANVKGTNEeVYALCFS 192
                 5799999999445****998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       383  (0.021362); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 1318.88
//
Query:       EFC35793.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.063   13.7   0.0      0.096   13.1   0.0    1.2  1  HsbA      Hydrophobic surface binding protein A


Domain annotation for each model (and alignments):
>> HsbA  Hydrophobic surface binding protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   5.3e-06     0.096      35      86 ..      69     120 ..      61     124 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 5.3e-06
                 HHHHHHHHHHHHHHHHHHHTS----HHHHHHHHHHHHHCHHHHHHHHHHHHH CS
        HsbA  35 lsasnalvsaikkattdaqasapltdeealalaqavqtLepdvkaaldalia 86 
                 +++s+++  ++kka ++a   a  +++e ++l+ ++q Le+++k++++++i+
  EFC35793.1  69 HTTSSKMFFDLKKAKQQAAEKAVYSEQEQNELIKNYQVLEDKFKKLTENIIE 120
                 56677777799**************************************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1581  (0.0881812); expected 358.6 (0.02)
Passed bias filter:                      614  (0.0342462); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 1116.05
//
Query:       EFC35794.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.021   14.6   2.6       0.03   14.2   2.6    1.2  1  Band_3_cyto  Band 3 cytoplasmic domain
       0.03   13.0   3.4       0.03   13.0   3.4    1.1  1  Ndc1_Nup     Nucleoporin protein Ndc1-Nup
       0.37    9.1   1.4       0.36    9.2   1.4    1.2  1  Mem_trans    Membrane transport protein
       0.66    9.1   2.3       0.79    8.9   2.3    1.2  1  Zip          ZIP Zinc transporter
       0.75   10.0  15.8        1.1    9.5  15.8    1.2  1  PNISR        Arginine/serine-rich protein PNISR
        1.1    9.3  11.8        1.9    8.6  11.8    1.3  1  PARM         PARM
        1.3    7.8  15.2        1.9    7.3  15.2    1.1  1  DUF5427      Family of unknown function (DUF5427)


Domain annotation for each model (and alignments):
>> Band_3_cyto  Band 3 cytoplasmic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   2.6   1.2e-05      0.03      57     172 ..      17     204 ..       7     211 .. 0.57

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.2e-05
                  TTSS-HHHHHHHHHHHTS-EE-CCHHHHHT-EEE-EE-TTS----------EE--SSS-SS-HHHHHHTTTTTSS--..................... CS
  Band_3_cyto  57 edqlkeedreevlraLLlkhrHqneekekgvllptvrslssigsllsekkkaskellskqssleteeakaseslsksssees................ 138
                   + +++e+ ++vlr+   k   ++++++ +     + s ss++ ++s+++ ++k++++  ++ +t++  +++s+ +++ ++                 
   EFC35794.1  17 PQRISTEKPKKVLRSSVSKNDQKQHTEA-KKEEVKQASSSSLSAEKSSHHIQTKQEQDPVNTSNTSTEDKKSSIAEKKVSRAlskyekrdeqllstwg 113
                  5667788888888888877766666333.223333334444444444444333333333333333322333333322222223567777888888888 PP

                  ..............................................................--SSTTGGGCCGGGS-TT-EEEEEEEEEE CS
  Band_3_cyto 139 .........................................................lsssleeekkkkkekilkkipegaEatlvLvgev 172
                                                                           +  ++ ++k+ k      +ip+  E+ +vL+  +
   EFC35794.1 114 kwlssgetnkyvanddvyyfemnncfpdcffldieggdidmetivfvrvrgystviaTMIQQVDDKNDKAVLTSIQIPKSIESDKVLLPII 204
                  8888888888888888888888888888888888888888888888888888888652223333333333333347788888888877655 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   3.4   1.2e-05      0.03     367     465 ..       7     103 ..       3     227 .. 0.55

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
    Ndc1_Nup 367 knkasapvkelprlsksplkkkddeifgnsltaeaspkssssskegvekalsslakspgqspsptarls............prarkllekaksrllske 453
                 ++k+ ++v+e +r+s++++kk     +++s ++++++++++++ke+v++a ss  ++ ++s++ + +++            +++ +  ek+ sr+ls  
  EFC35794.1   7 TQKQLKNVEEPQRISTEKPKKV----LRSSVSKNDQKQHTEAKKEEVKQASSSSLSAEKSSHHIQTKQEqdpvntsntsteDKKSSIAEKKVSRALS-- 99 
                 4667778889999998888884....44344455555556666666666666666666655222222222333222232331222222222222222.. PP

    Ndc1_Nup 454 qkealsestikk 465
                         +++k
  EFC35794.1 100 --------KYEK 103
                 ........1111 PP

>> Mem_trans  Membrane transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   1.4   0.00014      0.36     151     225 ..      41     112 ..       7     219 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00014
   Mem_trans 151 aklliseefpdtaasivsikvdsdvvsldgrk.pleteaeikedgklhvtvrksnasrsdivssstprpsnltnae 225
                   + ++ee ++++ s+ s+++ s+ ++ ++++ p++t++   ed+k+ ++ +k +       s+ ++r+++l + +
  EFC35794.1  41 HTEAKKEEVKQASSSSLSAEKSSHHIQTKQEQdPVNTSNTSTEDKKSSIAEKKVSRAL----SKYEKRDEQLLSTW 112
                 3333444444777777777777777777766668888888888888777665544332....23334555555555 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   2.3   0.00031      0.79     110     172 ..      33     117 ..       6     178 .. 0.51

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00031
         Zip 110 tpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqas......................e 172
                  +k+ +++++e+++++  ++++++ s ek +h  +++ ++d + +   + ++k++s++e++                       +
  EFC35794.1  33 VSKNDQKQHTEAKKEEVKQASSSSLSAEKSSHHIQTKQEQDPVNTSNTSTEDKKSSIAEKKVsralskyekrdeqllstwgkwlS 117
                 3344444444444444444444444444444444444444444444444444444444443344444444444445555555550 PP

>> PNISR  Arginine/serine-rich protein PNISR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5  15.8   0.00044       1.1      39     144 ..       8     110 ..       3     118 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00044
       PNISR  39 aerrkeekkesskeeeeaknprnlakskfdsedeksdeeeeegaegedsesqekasskksevdeqespeeeeaarkeieesspaeeeeeeepeakteee 137
                 +++ k++++ + + +e++k++ + + sk d+++  + ++ee +++  +s+s ek+s++ +  ++++ p +++++  e+++ss ae++ +      ++e+
  EFC35794.1   8 QKQLKNVEEPQRISTEKPKKVLRSSVSKNDQKQHTEAKKEEVKQASSSSLSAEKSSHHIQ-TKQEQDPVNTSNTSTEDKKSSIAEKKVSR--ALSKYEK 103
                 344455666666666666666666666666666555555555566666667777666666.55666665555555555666666555444..4457888 PP

       PNISR 138 kqaelml 144
                 + ++l+ 
  EFC35794.1 104 RDEQLLS 110
                 8888765 PP

>> PARM  PARM
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  11.8   0.00073       1.9     143     212 ..      16      85 ..       3     104 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00073
        PARM 143 spsslstslppevssasvstnhssaetstkptgapttpesp.teehssaetptshataepvpeettsqatv 212
                  p+ +st  p +v  +svs n+  ++t +k++++++++ s   +e+ss++ +t++  ++pv++ +ts +  
  EFC35794.1  16 EPQRISTEKPKKVLRSSVSKNDQKQHTEAKKEEVKQASSSSlSAEKSSHHIQTKQE-QDPVNTSNTSTEDK 85 
                 58889999**********************99999887665168888888888765.56666665554433 PP

>> DUF5427  Family of unknown function (DUF5427)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3  15.2   0.00075       1.9      39     150 ..      10     122 ..       5     134 .. 0.47

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00075
     DUF5427  39 eLeeLakkesrpaTPrvksn.kskkaspkkkksaeepakeekkkeeessedkrksvestr.slea.setpseeeseeqeaekkeeeeeeaeeeeadpia 134
                 +L +++++ +r +T + k+  + ++ s++ +k+++e +kee k++++ss +++ks    + ++e+   + s++++e ++++ +e++ ++a ++ ++  +
  EFC35794.1  10 QLKNVEEP-QRISTEKPKKVlR-SSVSKNDQKQHTEAKKEEVKQASSSSLSAEKSSHHIQtKQEQdPVNTSNTSTEDKKSSIAEKKVSRALSKYEKRDE 106
                 45666663.4555544444431.2222222223333333333333333333334433333033332222222222333333335555566666667777 PP

     DUF5427 135 sgsgWWgsilatasaa 150
                 +  + Wg++l+++++ 
  EFC35794.1 107 QLLSTWGKWLSSGETN 122
                 7778899999999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2711  (0.151208); expected 358.6 (0.02)
Passed bias filter:                      720  (0.0401584); expected 358.6 (0.02)
Passed Vit filter:                       124  (0.00691617); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.48
# Mc/sec: 1458.11
//
Query:       EFC35795.1  [L=282]
Description: 3-hydroxyisobutyrate dehydrogenase, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-42  145.5   0.6    2.2e-42  144.9   0.6    1.3  1  NAD_binding_2   NAD binding domain of 6-phosphogluconate dehy
    6.7e-31  107.1   0.1    1.1e-30  106.4   0.1    1.4  1  NAD_binding_11  NAD-binding of NADP-dependent 3-hydroxyisobut
    9.9e-08   32.5   0.1    2.1e-07   31.4   0.1    1.5  1  F420_oxidored   NADP oxidoreductase coenzyme F420-dependent
      1e-06   28.9   0.0    1.8e-06   28.0   0.0    1.5  1  Shikimate_DH    Shikimate / quinate 5-dehydrogenase
    1.9e-05   24.1   0.0    3.2e-05   23.3   0.0    1.3  1  2-Hacid_dh_C    D-isomer specific 2-hydroxyacid dehydrogenase
     0.0043   16.4   0.3     0.0079   15.5   0.3    1.4  1  AlaDh_PNT_C     Alanine dehydrogenase/PNT, C-terminal domain
     0.0079   16.1   0.1      0.012   15.5   0.1    1.3  1  3HCDH_N         3-hydroxyacyl-CoA dehydrogenase, NAD binding 


Domain annotation for each model (and alignments):
>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  144.9   0.6   8.6e-46   2.2e-42       1     158 []      15     176 ..      15     176 .. 0.97

  Alignments for each domain:
  == domain 1  score: 144.9 bits;  conditional E-value: 8.6e-46
                    EEEEE--SHHHHHHHHHHHHTT-E.EEEE-SSHHHHHHHHHTTEEE-SSHHHHHHHCSEEEE-SSSHHHHHHHHHS....HCCC--TT-EEEE-S- CS
  NAD_binding_2   1 kigfiGlGvMGsnmalnllkagyk.vavynrtkekveelvaegakaaesieelvasldvvitmvkagkavdevieg....llealkkgdilidgst 91 
                    ++gf+G+GvMG+++a+nl+++gyk ++vy rtk+k++ l++ gak+a+s++e+ a+ dvvi +v   ++v++vi +    +l+ +k+g +++d++t
     EFC35795.1  15 RVGFLGVGVMGKSIATNLINKGYKnMTVYTRTKSKADPLIELGAKLAASPKEVGANSDVVISIVGYPSDVRSVILDeengVLSGMKEGGVIVDMTT 110
                    58********************96589***********************************************9999****************** PP

                    --HHHHHHHHHHHHHTT-EEEEEEEESHHHHHHHT-EEEEEEE-HHHHHHHHHHHHHHEEEEEEE-E CS
  NAD_binding_2  92 sspedtrelakelkekglkfldaPVSGGeegAekGtLsimvGGseeafervkpvleaigakvthviG 158
                    s+p+ + e+++++kekg+  ldaP SGG+ gA+++tL+i+vGG+e ++ +v+p++e+ig+++  ++G
     EFC35795.1 111 SQPSLAVEIYNKAKEKGVYSLDAPCSGGDIGARNATLTIFVGGDEPVLGAVTPIFESIGKTIN-FMG 176
                    ************************************************************998.445 PP

>> NAD_binding_11  NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  106.4   0.1   4.2e-34   1.1e-30       1     103 [.     179     280 ..     179     282 .] 0.98

  Alignments for each domain:
  == domain 1  score: 106.4 bits;  conditional E-value: 4.2e-34
  NAD_binding_11   1 GaGqavKlvnnlllainlaaasEalvlaekaGldpekvlevinassgrsnalenklpqrvlsrdfdpgFaldlmlKDlglalelareagaplpll 95 
                     G+Gq++K++n++++a++++ ++E+l++a+kaGld+++ l+++++++++s++l+++ p r+l+rdf+pgF +++++KD++++l++a+++++ lp l
      EFC35795.1 179 GKGQHAKMANQVIIATSMIGVCEGLLYAHKAGLDVHQTLKAVSGGAANSFSLQSYGP-RILKRDFEPGFYVEHFIKDMEIVLSEANKMQLVLPGL 272
                     99*******************************************************.8************************************ PP

  NAD_binding_11  96 alaeqlya 103
                     +la+ ly 
      EFC35795.1 273 NLAKMLYD 280
                     ****9997 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   0.1   8.1e-11   2.1e-07       1      78 [.      15      88 ..      15     110 .. 0.77

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 8.1e-11
                   EEEEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHHHHHC-EEECECHHHHHHH-SEEEE-S-.HHHHHHHH CS
  F420_oxidored  1 kigiiGaGnmgealasgllaagaqpheivvansrnpekaeelaeelgvkvtavdneeaaeeadvvvlavk.pedveevl 78
                   ++g++G G mg+++a +l+++g   ++++ + +r+++ka+ l e lg+k+ a + +e+ +++dvv+  v  p+dv +v+
     EFC35795.1 15 RVGFLGVGVMGKSIATNLINKG--YKNMT-VYTRTKSKADPLIE-LGAKLAA-SPKEVGANSDVVISIVGyPSDVRSVI 88
                   69********************..44455.669********965.5789988.8999********97774255666665 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.0   7.2e-10   1.8e-06      12      84 ..      13      79 ..       4     126 .. 0.81

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 7.2e-10
                  T-EEEEES-SHHHHHHHHHHHCCT-CEEEEEESSHHHHHHHHHHHT.ET-EEEEGCGHHHHHHT-SEEEE-SS CS
  Shikimate_DH 12 ekkvlliGaGemaelvakhLlakgvkkvvvaNRtlerakelaeelkgeeiealkleelkellaeadvvisata 84
                  + +v  +G G m++ +a++L++kg+k+++v  Rt ++a+ l e   ++        + ke+ a++dvvis ++
    EFC35795.1 13 STRVGFLGVGVMGKSIATNLINKGYKNMTVYTRTKSKADPLIELG-AK-----LAASPKEVGANSDVVISIVG 79
                  578999**********************************97644.33.....44455566678888887665 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.0   1.3e-08   3.2e-05      37     126 ..      14     108 ..       4     115 .. 0.89

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 1.3e-08
                   SEEEEES-SHHHHHHHHHHHHTT-.EEEEESSSHHHHHCHHHHTCEEC.SHHHHHHH-SEEEE-S--STTTTTSBSHHH...HHCSTTTEEEEES CS
  2-Hacid_dh_C  37 ktvGiiGlGrIGqavakrlkafgm.kviaydrskkkeeeeeelgvelv.sleellaesDivslhlpltpetrhlinaee...lakmkkgailiNt 126
                    +vG +G+G +G+++a  l   g  ++++y r+k+k +   elg++l+ s +e+ a+sD+v+  + +  + r +i +ee   l+ mk+g +++ +
    EFC35795.1  14 TRVGFLGVGVMGKSIATNLINKGYkNMTVYTRTKSKADPLIELGAKLAaSPKEVGANSDVVISIVGYPSDVRSVILDEEngvLSGMKEGGVIVDM 108
                   68*****************9999978999****9999999999998777*******************99999996664455999***9999975 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.3   3.1e-06    0.0079      31     131 ..      16     112 ..      10     129 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 3.1e-06
                  EEEESTSHHHHHHHHHHHHTT-.EEEEEESSHHHHHHHHHTTTCECEEHCHHHHHHHHHHHH-SEEEE---BTTSS---SC-HH..HHHTS-TTEEEE CS
  AlaDh_PNT_C  31 vlviGgGvaGlqAiatakglga.kVtvlDvrparleqleslgakfvevlksqeellaeavkeadvvigtvlipGkkaPkLvtee..mvksMkpgsViv 125
                  v  +G+Gv G + + +  + g  + tv+   ++++  l +lgak    l   +++ +e  +++dvvi+ v  p     ++++ee  +++ Mk+g Viv
   EFC35795.1  16 VGFLGVGVMGKSIATNLINKGYkNMTVYTRTKSKADPLIELGAK----L---AASPKEVGANSDVVISIVGYPSDVRSVILDEEngVLSGMKEGGVIV 106
                  55677777777655555555541445555555555556666666....3...34444556789****************999874479********** PP

                  ETTGGG CS
  AlaDh_PNT_C 126 DvAidq 131
                  D+ ++q
   EFC35795.1 107 DMTTSQ 112
                  **9887 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   4.9e-06     0.012       2      36 ..      16      50 ..      15      87 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 4.9e-06
                EEEE--SCCHHHHHHHHHHTT-EEEEE-S-HHHHH CS
     3HCDH_N  2 vaviGaGtmGagiaavfasagleVvlvdiseeale 36
                v+ +G G+mG++ia+ ++++g++   v +++++ +
  EFC35795.1 16 VGFLGVGVMGKSIATNLINKGYKNMTVYTRTKSKA 50
                899*******************8666555554444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (282 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       363  (0.0202465); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1850.92
//
Query:       EFC35796.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.1e-07   31.0  10.0    6.2e-07   29.4   7.5    2.4  2  Folate_rec  Folate receptor family


Domain annotation for each model (and alignments):
>> Folate_rec  Folate receptor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4   7.5   3.5e-11   6.2e-07      19     108 ..      48     147 ..      38     153 .. 0.73
   2 ?    0.2   0.0     0.033   5.9e+02     140     170 ..     158     188 ..     151     190 .. 0.64

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 3.5e-11
                 GGGGGGGTTSBSSBHHHHHHTTSSSXTTTSS.TTTT.........SCXXHHHHHHHHHHHHHHHHXSCCGGGEEE..TCCEEEXSEEEXHHHHHHHHHH CS
  Folate_rec  19 leeCspykensCCtsetseelssdesilanfrwerC.........gelsqeCekfleqlecfyecsphlglwikp..erkerilkvpLCeelCdawfea 106
                 l  C++y+ nsCCt + s++++++ +  +  +  +           +    C + l+q  c y csp + ++i++  +   + + + LC+++Cd+++++
  EFC35796.1  48 LATCQWYNPNSCCTVDSSKKIKQGWESQSGRNSGSSnvtipqflvEAFAGGCLDELHQYIC-YLCSPGQTNFIEEkiQILGQKSILYLCSSFCDRLYSK 145
                 445***********9999998876554332222222223333354778889**********.66********999443344445556************ PP

                 TT CS
  Folate_rec 107 Ck 108
                 C 
  EFC35796.1 146 CA 147
                 *5 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.033
                 HHHSSSHHHHHHHTTTTSEEEXSSXTTSSSS CS
  Folate_rec 140 kqvfangtdlcesvlgesfkvaekskgskrC 170
                  + +a+g+d+ces l++  +  + +    +C
  EFC35796.1 158 ITSYASGKDFCESGLNDPSNQLQIKVRDANC 188
                 566899*****99887744444333344555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1439.13
//
Query:       EFC35797.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       578  (0.0322383); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.21s 00:00:00.65 Elapsed: 00:00:00.41
# Mc/sec: 867.11
//
Query:       EFC35798.1  [L=249]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.6e-52  178.9   0.0    1.9e-52  178.6   0.0    1.0  1  Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase famil


Domain annotation for each model (and alignments):
>> Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  178.6   0.0   1.1e-56   1.9e-52     130     342 .]      12     225 ..       2     225 .. 0.88

  Alignments for each domain:
  == domain 1  score: 178.6 bits;  conditional E-value: 1.1e-56
                   T-.S...CS-EE--HHHHHHHHHHHHHHHHHHHHTT-SEEEEEE-CTSHHHHHH-TTT----STTSSSHHHHHHHHHHHHHHHHHHH-SSS..EEEE CS
  Oxidored_FMN 130 eeesaeevykkeltkeeikqliqefveAAkraieAgfDgVeihganGYLlnqFlspksnkrtDeygGslenRarFllevvdaVkeavgeer..vgyR 224
                    +e++ +  +k+l+ eeik ++ ++++AA +a+ AgfDgVe h+anGYL++qFl+++ nkrtDeygGs+enR+rF++e + a  e   +e   vg+R
    EFC35798.1  12 TREQQLPTTPKALSIEEIKVIMGQYKQAASNAKLAGFDGVELHAANGYLVDQFLQNGVNKRTDEYGGSIENRLRFMREAISACIEGFDNESdrVGIR 108
                   2355666669****************************************************************************9999888**** PP

                   EECE--STTS--HHHHHHHHHHHCHCCEEEEEEETT-SSSSSTTS-TTTTHHHCCTT.HHH....HHHCCCHSSEEEE-SS--SHHHHHHHHHTTS- CS
  Oxidored_FMN 225 lSpedvvekgldfaetaqkivllkelekrlkdgkklalvhaaeprkrgagsvrteqe.knt....efvkevwkkplitvgriadeekaaeivaegea 316
                   lSp++ + + +d+       + l e +++++d   la++h++epr  g  ++   q  ++     + +k +   p+i +g+++ ++ a+ + +eg  
    EFC35798.1 109 LSPSGCFLEISDSDP-----KPLFEAAVKALDEYDLAYIHLVEPRISGGANSDDGQAeSKPvvvtKELKPLTRSPIISAGGFTPAT-AKSTTEEGAT 199
                   *******98877644.....578888899999999**********98766666554322223455999******************.9999****** PP

                   SEEEESTHHHH-TTHHHHHHCCTCGG CS
  Oxidored_FMN 317 dLvamgRefladpdlveklkkglpln 342
                   d++a+gR+f+++pdlve++++g pln
    EFC35798.1 200 DMIAFGRHFISNPDLVERIRNGHPLN 225
                   *********************99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (249 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       353  (0.0196888); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1705.42
//
Query:       EFC35799.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1061.19
//
Query:       EFC35800.1  [L=183]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    9.7e-39  133.3   0.0    1.2e-38  133.0   0.0    1.1  1  PEPCK_ATP  Phosphoenolpyruvate carboxykinase


Domain annotation for each model (and alignments):
>> PEPCK_ATP  Phosphoenolpyruvate carboxykinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.0   0.0   6.9e-43   1.2e-38       2     121 ..      52     173 ..      51     177 .. 0.98

  Alignments for each domain:
  == domain 1  score: 133.0 bits;  conditional E-value: 6.9e-43
                 -EEES--HHHHHHHHHHTTS.-EE-TTS-EEE--TT--S--GGGEEEE--TTTTTTS-BTTTBEEE-HHHHHHHHHHHHHHHHTS.-EEEEEEEE-SST CS
   PEPCK_ATP   2 kvirnlsvaeLveealkree.gkltstgalvvetgkktgRspkdkfiVedeetedkiwWgkvnkpiseekfealkekvleylkek.elyvvdafagadp 98 
                 +v++n+sv+ L+e+alk+e+ + lt tgalv+ +g+ktgRspkdk+iV++e+++d+iw g vn+p+se++f  ++e++++yl+++ +lyv+d++ag+dp
  EFC35800.1  52 RVYHNASVPVLYEQALKHERgTALTCTGALVAFSGQKTGRSPKDKRIVSEETSKDDIWFGPVNIPLSEDSFMVNRERAVDYLNTReQLYVFDGYAGWDP 150
                 699***************99899**************************************************************9************* PP

                 TT-EEEEEEES-HHHHHHHHHHS CS
   PEPCK_ATP  99 kyrlkvrviterawqalfvknll 121
                 kyr+k+rv+ +ra++alf++n++
  EFC35800.1 151 KYRIKIRVVSTRAYHALFMRNIF 173
                 *********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       396  (0.0220871); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 1197.65
//
Query:       EFC35801.1  [L=155]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
          7    6.8   8.7        2.2    8.5   2.2    2.0  2  dsRBD2      Double-stranded RNA binding domain 2


Domain annotation for each model (and alignments):
>> dsRBD2  Double-stranded RNA binding domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.5    0.0079   1.4e+02      79     131 ..      22      72 ..       1      77 [. 0.63
   2 ?    8.5   2.2   0.00012       2.2      41      99 ..      83     140 ..      79     149 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.0079
      dsRBD2  79 eeelengkevakekeesaesgssfrCevkilsksqdlilecspkelykkqsda 131
                 e+e+ ++ ++   +++  + +++++ +v  + ++q+  l+  +++ y++q+++
  EFC35801.1  22 EQEIIDQLDMI--DDQPGSINHQYESNVGPFIQHQQYELDDDQQQYYQQQQHS 72 
                 22223333333..3334446789999999999999999*99999999999886 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00012
      dsRBD2  41 rqhrLsePvfsissapvksssellrsakklkdseskekeeelengkevakekeesaesg 99 
                 +qh+L eP+++ +++  +  + +  ++++ ++ + +++ +e++n k+ ++ k+e+++++
  EFC35801.1  83 QQHELDEPYYNNQQH-HSRRNIIADKRSNQQQYNDDSQYREYNNTKGRNQIKQEMPSQT 140
                 79*********9974.4555556666666677777777888888888888888877643 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (155 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2362  (0.131742); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1001.93
//
Query:       EFC35802.1  [L=218]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.6e-28   98.1   0.0    1.4e-27   97.1   0.0    1.5  1  Acetyltransf_2  N-acetyltransferase


Domain annotation for each model (and alignments):
>> Acetyltransf_2  N-acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.1   0.0   7.6e-32   1.4e-27       5     134 ..      33     183 ..      30     215 .. 0.84

  Alignments for each domain:
  == domain 1  score: 97.1 bits;  conditional E-value: 7.6e-32
                     HHHHHHHHHHHS-EE-HHHHTT............-----SHHHHHHHHTTST--B-HHHHHHHHHHHHHHTT-EEEEEEEEEETTGGSSS..... CS
  Acetyltransf_2   5 LrellqahlraiPFENldvllg............eeieldlealfdklVkkkRGGyCyelNgLlarvLkelGFevtllagrvvvkaeeaa..... 82 
                     L++++ +h++ iPFENl+                 +++ld +++f k+V + RGG+C+e+N Llar+L+e GF+v+++++r v++ +e       
      EFC35802.1  33 LHAIVWNHATHIPFENLATIYPdeyrivsdsnskIKVSLDPNDIFRKMVLNDRGGFCFEQNLLLARALREFGFTVKPIGARGVNRLAEVDpisgl 127
                     99***************99887778888888877889********************************************99887663211111 PP

                     .SSSCEEEEEEEEETTE.EEEE-SSSSCG..-SS-EESSTTCEEEESSE.EEEEEE CS
  Acetyltransf_2  83 .stertHllllVtidge.tylvDvGFGgs.tltaplelesgkdqqtthg.ifrlve 134
                        + tHl+llV+ ++  tylvD G G    + +pl+l +g++++++ g +frlv 
      EFC35802.1 128 pVGPFTHLALLVDCQDGnTYLVDNGLGWGgMPRSPLPLVNGSEKTESTGeVFRLVL 183
                     35689*******986655*********9989**********999999888***974 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       251  (0.0139997); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 1433.85
//
Query:       EFC35803.1  [L=405]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-22   78.8   5.9    1.5e-13   50.3   0.1    4.8  5  DUF4116   Domain of unknown function (DUF4116)
     0.0077   17.2   0.2      0.024   15.6   0.2    1.9  1  DUF2018   Domain of unknown function (DUF2018)
  ------ inclusion threshold ------
       0.14   12.3   0.8       0.49   10.5   0.4    2.1  2  KH_8      Krr1 KH1 domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.1   1.2e-08   7.4e-05      15      48 ..     146     179 ..     135     181 .. 0.89
   2 !   50.3   0.1   2.4e-17   1.5e-13       1      49 []     182     230 ..     182     230 .. 0.97
   3 ?   -1.4   0.0      0.32   1.9e+03      13      47 ..     244     268 ..     239     270 .. 0.62
   4 !    4.6   0.1    0.0046        27      22      47 ..     328     354 ..     298     356 .. 0.82
   5 ?    0.0   0.0      0.12   7.2e+02      28      40 ..     392     404 ..     378     405 .] 0.67

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 1.2e-08
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                  l+ +s+eL+nD e +++ vk ng +l+ya++++
  EFC35803.1 146 TLEEISHELRNDPEYIKARVKENGLFLYYAHPDI 179
                 6899***************************986 PP

  == domain 2  score: 50.3 bits;  conditional E-value: 2.4e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +r+ivlea+++ng a+k+l+ +L++D ++v+kAv+ ng++++y+  e+r
  EFC35803.1 182 NRDIVLEAIRNNGAAFKFLPFNLRQDEDFVKKAVELNGDSFYYLNREFR 230
                 8*******************************************98887 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.32
     DUF4116  13 gsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 g+a++ + e+++          k++ ++++ +s++
  EFC35803.1 244 GMAIQRAGENIR----------KSHFSIFKSVSND 268
                 667777777766..........5555666666665 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.0046
     DUF4116  22 eLknDkeivlkAvkqngtalsyas.ee 47 
                 e++ D +++ kA+++n  + +y+s ++
  EFC35803.1 328 EITLDEQVIVKAMNKNILVANYLSlDH 354
                 566799999999999999999998555 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.12
     DUF4116  28 eivlkAvkqngta 40 
                 +i+ + +++++++
  EFC35803.1 392 DIARELIRKYPCC 404
                 5566666666654 PP

>> DUF2018  Domain of unknown function (DUF2018)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.2   4.1e-06     0.024      23      63 ..     353     392 ..     333     397 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 4.1e-06
                 HHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHCCCHHHHHHH CS
     DUF2018  23 keLekllerlaalellleekGlekvekeikslilenkdeve 63 
                 + L  +l+++a+++++++++G+e +++++ +lil+n++ v+
  EFC35803.1 353 DHLTTVLNDHALIKQMIQHQGVE-WNEDMAELILKNSSSVD 392
                 67999******************.************99987 PP

>> KH_8  Krr1 KH1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.38   2.3e+03       3      39 ..     262     298 ..     260     302 .. 0.82
   2 ?   10.5   0.4   8.2e-05      0.49      27      81 .]     307     361 ..     293     361 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.38
        KH_8   3 fevlfpkyrekylkeveekikklleekklklevdlke 39 
                 f+ +  ++r+ y  e++    + l e  l+ +v+ +e
  EFC35803.1 262 FKSVSNDWRAIYWVEKSYPFYSNLIESILTSKVNESE 298
                 6777789999999999999999999999999998776 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 8.2e-05
        KH_8  27 eekklklevdlkerslkvsTtekTrDPyiilkardlikLisrgvpleeakkvleD 81 
                 ++++l   +d++ + + + Tte T D  +i+ka +   L++   +l++ + vl+D
  EFC35803.1 307 SKEQLLKLLDISHKAFLMGTTEITLDEQVIVKAMNKNILVANYLSLDHLTTVLND 361
                 455666679999**********************************999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       704  (0.039266); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 2519.25
//
Query:       EFC35804.1  [L=128]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.1e-17   61.4   5.0    4.1e-14   52.9   0.8    2.0  2  Ank_2     Ankyrin repeats (3 copies)
    2.4e-12   45.9   4.5     0.0013   19.1   0.0    3.8  4  Ank_3     Ankyrin repeat
    8.4e-09   35.8   0.1    5.4e-07   30.0   0.0    2.3  2  Ank_4     Ankyrin repeats (many copies)
    6.6e-08   32.7   0.5       0.11   12.9   0.0    3.1  3  Ank_5     Ankyrin repeats (many copies)
      8e-08   32.4   4.3       0.02   15.3   0.0    4.0  3  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.2   2.4e-06    0.0085      27      80 ..       3      62 ..       1      65 [. 0.55
   2 !   52.9   0.8   1.1e-17   4.1e-14       1      81 [.      38     125 ..      38     127 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.4e-06
       Ank_2 27 ktaLhyAakngnleivklLleh......adndgrtpLhyAarsghleivklLlek.gadin 80
                +++L++ + n ++ ++++L  +      +++  ++ L +A+++++lei+k+Ll   ++++n
  EFC35804.1  3 NSPLQAIVNN-DIATLSTLQLQdcindlQTDRKTSLLAIACEKSNLEIIKILLSVpNINVN 62
                5666655544.34445555533454342223344455888888888888888843455554 PP

  == domain 2  score: 52.9 bits;  conditional E-value: 1.1e-17
       Ank_2   1 LhlAakngnlelvklLl..egadpn.k.ngktaLhyAakngnleivklLleh......adndgrtpLhyAarsghleivklLlekgadinl 81 
                 L +A+++ nle++k+Ll     ++n +  +k +L++A+++g++eivklLl+       ++++g t+L  +++ g++ ivk Ll++ ++in+
  EFC35804.1  38 LAIACEKSNLEIIKILLsvP--NINvNlGHKPPLYIACERGSEEIVKLLLNIptinvnQEYTGLTALCKSCKLGNILIVKQLLNN-SNINV 125
                 789***9779*******544..444433569*******************945555445599*********99**********54.56554 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.84     3e+03       2      13 ..       2      12 ..       1      22 [. 0.62
   2 !   14.8   0.1   8.6e-06     0.031       4      30 ..      36      62 ..      33      63 .. 0.91
   3 !   19.1   0.0   3.5e-07    0.0013       4      30 ..      67      93 ..      65      94 .. 0.94
   4 !   11.3   0.2   0.00012      0.42       2      30 ..      98     126 ..      97     127 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.84
       Ank_3  2 GetpLhlAarsg 13
                G++pL  A+ ++
  EFC35804.1  2 GNSPLQ-AIVNN 12
                777776.33333 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 8.6e-06
       Ank_3  4 tpLhlAarsgnleivkfLlenkgadvn 30
                ++L +A++  nlei+k Ll  ++++vn
  EFC35804.1 36 SLLAIACEKSNLEIIKILLSVPNINVN 62
                5677*********************99 PP

  == domain 3  score: 19.1 bits;  conditional E-value: 3.5e-07
       Ank_3  4 tpLhlAarsgnleivkfLlenkgadvn 30
                 pL++A++ g+ eivk+Ll+++ ++vn
  EFC35804.1 67 PPLYIACERGSEEIVKLLLNIPTINVN 93
                59*******************999999 PP

  == domain 4  score: 11.3 bits;  conditional E-value: 0.00012
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 G t+L   ++ gn+ ivk Ll+n +++vn
  EFC35804.1  98 GLTALCKSCKLGNILIVKQLLNNSNINVN 126
                 78999999***************999999 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.0   0.0   1.5e-10   5.4e-07       3      55 .]      36      85 ..      34      85 .. 0.92
   2 ?    3.7   0.0     0.027        98      35      52 ..      98     115 ..      90     127 .. 0.57

  Alignments for each domain:
  == domain 1  score: 30.0 bits;  conditional E-value: 1.5e-10
       Ank_4  3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklLl 55
                ++L  a+++++le++++Ll + ++in   n  + ++l+iA+ rg+ ei+klLl
  EFC35804.1 36 SLLAIACEKSNLEIIKILL-SVPNINV--NLGHKPPLYIACERGSEEIVKLLL 85
                678899*************.7888888..999********************8 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.027
       Ank_4  35 GetalhiAakrgnveilk 52 
                 G+tal + +k gn+ i+k
  EFC35804.1  98 GLTALCKSCKLGNILIVK 115
                 555555555555543333 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.0     3e-05      0.11      10      44 ..      28      63 ..      22      64 .. 0.77
   2 !    8.5   0.0   0.00073       2.6      19      36 ..      68      85 ..      58      94 .. 0.81
   3 !    9.4   0.1   0.00038       1.4       9      44 ..      92     125 ..      88     127 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3e-05
       Ank_5 10 nrldgggntpLhvAakygaadvvrlLl.argadlnl 44
                + +  ++++ L +A+++ +++++++Ll  ++ + nl
  EFC35804.1 28 DLQTDRKTSLLAIACEKSNLEIIKILLsVPNINVNL 63
                34444556*******************888877775 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00073
       Ank_5 19 pLhvAakygaadvvrlLl 36
                pL +A+++g+ ++v+lLl
  EFC35804.1 68 PLYIACERGSEEIVKLLL 85
                9***************** PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00038
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLlargadlnl 44 
                 v +++  g t+L+ ++k g+  +v+ Ll +++++n+
  EFC35804.1  92 V-NQEYTGLTALCKSCKLGNILIVKQLL-NNSNINV 125
                 4.4567788*******************.7776665 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.3   0.00064       2.3       6      28 ..      38      60 ..       1      64 [. 0.65
   2 !   15.3   0.0   5.7e-06      0.02       5      24 ..      68      86 ..      67      95 .. 0.81
   3 !    6.6   0.4    0.0033        12       2      28 ..      98     124 ..      97     127 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00064
                HHHHHHHTTHHHHHHHHTT.TSTT CS
         Ank  6 LHlAatngkkriiklLLhG.Anln 28
                L +A+   +++iik LL +  n+n
  EFC35804.1 38 LAIACEKSNLEIIKILL-SvPNIN 60
                335898788********.533444 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 5.7e-06
                HHHHHHHHTTHHHHHHHHTT CS
         Ank  5 PLHlAatngkkriiklLLhG 24
                PL +A+ +g+++i+klLL  
  EFC35804.1 68 PLYIACERGSEEIVKLLL-N 86
                9****************9.3 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.0033
                 SBBHHHHHHHHTTHHHHHHHHTTTSTT CS
         Ank   2 GnTPLHlAatngkkriiklLLhGAnln 28 
                 G T+L   +  g+  i+k LL+ +n+n
  EFC35804.1  98 GLTALCKSCKLGNILIVKQLLNNSNIN 124
                 78999988999**********544666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       601  (0.0335211); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 853.70
//
Query:       EFC35805.1  [L=209]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-16   61.1   2.4    2.1e-16   60.7   2.4    1.2  1  RhoGEF    RhoGEF domain
     0.0048   16.2   6.2     0.0055   16.0   6.2    1.2  1  SOG2      RAM signalling pathway protein


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.7   2.4   2.3e-20   2.1e-16      90     182 .]      67     161 ..      25     161 .. 0.78

  Alignments for each domain:
  == domain 1  score: 60.7 bits;  conditional E-value: 2.3e-20
                 HHHHHHCHHHHHHH.HHHHHHHHHHHHHHHHHHHTS.GGGTT--HHHHTTHHHHHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHHHHH CS
      RhoGEF  90 YseYcsnypnalkl.lkelskknkkfkafleeaeer.pecskldLeslLikPvqRlprYpLLLkellkntpeshpdyealkkaleaikevaseiN 182
                   +Y s+y++  ++ l +  ++ +kfk+++++ +++ + +++ldL+slLi+P+qR+++Y LL k++lk t+e+h+dye l+ + ++i++ a+eiN
  EFC35805.1  67 SNNYQSHYSRTVHTnLPQAYQEYPKFKQVIQDSSKNvKGTDGLDLTSLLIMPCQRIVKYCLLSKAILKETNENHSDYEMLNLTCQKIQQQAHEIN 161
                 4445555444333214445668999999999977776777*****************************************************99 PP

>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   6.2   6.1e-07    0.0055     248     383 ..      12      92 ..       2     197 .. 0.50

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 6.1e-07
        SOG2 248 sssgnsaspaangaqsetsersasssgvqssasstPlgegstsppgalsrqslsttgststltsssksrsssrsntnasastprslattpappasaesf 346
                  + +n++++++++++++++        +++++s+ P +++st++    +++++stt++tst+t  s++ +s+ s   ++++ p+  ++ p         
  EFC35805.1  12 PPPSNNTNNNNTNNNTPPPT-------LNTTSSPPPKKDTSTTT---NNTNNTSTTTNTSTTTNTSNNYQSHYSR-TVHTNLPQAYQEYP--------- 90 
                 33333333333333333222.......22223332333333332...3333334444444444444444433333.23333333333333......... PP

        SOG2 347 astltasrintlaavDeqlletletavklalvvysql 383
                                                    + 
  EFC35805.1  91 -----------------------------------KF 92 
                 ...................................22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2877  (0.160466); expected 358.6 (0.02)
Passed bias filter:                      714  (0.0398237); expected 358.6 (0.02)
Passed Vit filter:                        86  (0.0047967); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1195.50
//
Query:       EFC35806.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.3e-10   39.1  12.8    5.3e-10   39.1  12.8    2.0  2  ABC2_membrane    ABC-2 type transporter
  ------ inclusion threshold ------
      0.033   13.3  17.4      0.054   12.6  17.4    1.4  1  ABC2_membrane_3  ABC-2 family transporter protein
       0.43   10.9   6.9        6.6    7.1   0.2    2.5  2  DUF4064          Protein of unknown function (DUF4064)
        3.8    7.7   5.0        1.1    9.4   0.4    2.4  3  PufQ             PufQ cytochrome subunit


Domain annotation for each model (and alignments):
>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1  12.8   1.2e-13   5.3e-10      95     208 ..       2     115 ..       1     117 [. 0.88
   2 ?    1.4   0.4     0.041   1.8e+02      99     121 ..     144     160 ..     125     171 .. 0.50

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 1.2e-13
  ABC2_membrane  95 ayvlakvlvelpvsllqalifllivyflvgldlsrfflflllllltalaasslgllisalapsfedasqlaslvllpllllsGffipidsm.pkwl 189
                    +y+l+k+++e+p  l+  l+f++++y+lv+ + + f  ++ l+ll+ +++sslg +is++++    a +++ + ++++ ll+G+  ++ +m ++w 
     EFC35806.1   2 SYFLGKLTGEIPSLLIYPLVFVTFWYILVNPEAE-FYTYYGLFLLFEIVFSSLGYFISVFVQR-THAEFVGVMYIILCALLGGVQPTVRTMsKEWY 95 
                    7***************************888886.9999*******************88865.88*************************65555 PP

  ABC2_membrane 190 qw.iaylnPltyavealrsn 208
                       +   +P+++ave++  +
     EFC35806.1  96 TLvLVCSSPVRWAVELMYTV 115
                    55233447*******99776 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.041
  ABC2_membrane  99 akvlvelpvsllqalifllivyf 121
                    +      p++l++++i++l+  f
     EFC35806.1 144 S------PIILIAITIIFLVLSF 160
                    2......2222222222222222 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6  17.4   1.2e-05     0.054     205     344 ..       3     160 ..       1     165 [. 0.68

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.2e-05
  ABC2_membrane_3 205 ywlskilgdflvyllqlllilllafglgipfgnlglll.llfllfglayialgyllsslfknsetaqilifivilllsgffgglfp.ledlpsa 296
                      y+l+k++g     l+  l+++ +++   ++ +  +++   lfllf +++++lgy++s++++++ + ++ ++ +  +l++++gg+ p + ++++ 
       EFC35806.1   3 YFLGKLTGEIPSLLIYPLVFVTFWYI-LVNPEAEFYTYyGLFLLFEIVFSSLGYFISVFVQRTHAEFVGVMYI--ILCALLGGVQPtVRTMSK- 92 
                      67777777777777777777666554.466775555555**********************997755544444..469999999988899996. PP

  ABC2_membrane_3 297 lkwifsiiPffapglgllrlitgdplwe........................illsliilalfavvylllal 344
                        w + ++  ++p    + l++++   e                        + +s iil+++++++l+l++
       EFC35806.1  93 -EWYTLVLVCSSPVRWAVELMYTV---EirkyqesnqnvatalenygfsykaYYISPIILIAITIIFLVLSF 160
                      .56666666666666666666433...222244455567788889999999855666666666666666664 PP

>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   1.9     0.003        13      55      98 ..      34      78 ..      12      82 .. 0.73
   2 ?    7.1   0.2    0.0015       6.6      62      81 ..     146     165 ..     107     167 .. 0.65

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.003
     DUF4064 55 eflstllivlgvialiaivlgivgalllkknkk.vsGilfiiaai 98
                + + t+  +++++ ++++ lg + ++++ + +  + G+++ii  +
  EFC35806.1 34 AEFYTYYGLFLLFEIVFSSLGYFISVFVQRTHAeFVGVMYIILCA 78
                5555666666667666666666666666655555*******9765 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0015
     DUF4064  62 ivlgvialiaivlgivgall 81 
                 i+l+ i +i++vl++vg+++
  EFC35806.1 146 IILIAITIIFLVLSFVGLVM 165
                 45666677777777777765 PP

>> PufQ  PufQ cytochrome subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.4   0.00024       1.1      17      49 ..      31      63 ..      28      73 .. 0.88
   2 ?   -0.5   0.2       0.3   1.4e+03      26      53 ..      95     122 ..      86     150 .. 0.75
   3 ?   -2.6   0.1       1.4   6.1e+03      28      32 ..     146     150 ..     124     165 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00024
        PufQ 17 apkaEFavYFaiilvaalPlAlltWvlaairsr 49
                 p+aEF++Y+++ l+  + +  l++ +++  +r
  EFC35806.1 31 NPEAEFYTYYGLFLLFEIVFSSLGYFISVFVQR 63
                599********************9999887666 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.3
        PufQ  26 FaiilvaalPlAlltWvlaairsrslte 53 
                 ++++lv + P+     ++ ++  r+++e
  EFC35806.1  95 YTLVLVCSSPVRWAVELMYTVEIRKYQE 122
                 6788888888877777777777777665 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.4
        PufQ  28 iilva 32 
                 iil+a
  EFC35806.1 146 IILIA 150
                 33332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1328  (0.0740699); expected 358.6 (0.02)
Passed bias filter:                      629  (0.0350828); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.44
# Mc/sec: 1661.74
//
Query:       EFC35807.1  [L=402]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00025   21.3   0.0    0.00065   19.9   0.0    1.7  1  BTB        BTB/POZ domain
  ------ inclusion threshold ------
        1.2    9.6   5.0          7    7.2   0.8    3.6  4  EF-hand_7  EF-hand domain pair


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   7.3e-08   0.00065      16     104 ..      61     163 ..      54     170 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 7.3e-08
                 EETTTEEEEE-HHHHHHH-HHHHHHHTST................TTTTCCCE.....EEEETTSGHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHHH CS
         BTB  16 vvgdgkefkahkavLaarSpyFkalftsk................eieessvs.....eielddvepeafealLefiYtgeleit.seenleelLaaad 92 
                 ++   k f +h + +  rS  F++++ s+                +      s       e +  + ++fe++++++Y++ ++    +++l+ ++ +a+
  EFC35807.1  61 KTS-FKDFNVHEFAV-KRSGLFRTMIDSNeqwklgkvddkfnidlT------SvegsiSTEGEPLKKKDFEIIFRYLYCDDFNCYmGTSTLKRIIDMAK 151
                 555.46677777764.689999999999988888777765544431......0334335666778889************999777799********** PP

                 HHT-HHHHHHHH CS
         BTB  93 llqiprlkkace 104
                 +l+ip+l++++ 
  EFC35807.1 152 YLDIPSLITKIL 163
                 ********9875 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.65   5.8e+03      36      53 ..     112     129 ..      79     136 .. 0.65
   2 ?    1.0   0.0     0.068   6.1e+02      23      52 ..     154     195 ..     143     203 .. 0.81
   3 ?   -0.1   0.0      0.15   1.3e+03      27      53 ..     232     258 ..     216     264 .. 0.68
   4 ?    7.2   0.8   0.00079         7      12      53 ..     338     372 ..     335     395 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.65
   EF-hand_7  36 gegsklsdeelellfkef 53 
                  eg++l ++  e +f+ +
  EFC35807.1 112 TEGEPLKKKDFEIIFRYL 129
                 677777777788877765 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.068
   EF-hand_7  23 ellrllrkifqga...........gegsklsdee.lellfke 52 
                 ++ +l++ki +g+           + + +l+++e ++l+fk 
  EFC35807.1 154 DIPSLITKILDGIqfslkyfpikySLKGELTEHEiVDLIFKL 195
                 677799999999999999999999888888998868888886 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.15
   EF-hand_7  27 llrkifqgagegsklsdeelellfkef 53 
                 ll+++ +++  g+++++e l+ +++++
  EFC35807.1 232 LLQRHLTQNNKGFVITKEMLQPFSDCI 258
                 455555555999999999999999887 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.00079
   EF-hand_7  12 Dtdgdgyldkeellrllrkifqgagegsklsdeelellfkef 53 
                  +++ g+l+ +e  rll k     +e+++l+++e+e+l++++
  EFC35807.1 338 EKNRKGFLEISE--RLLDK-----DEKKVLDRKEMEELIEKV 372
                 577888888888..45565.....888888888877666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1252  (0.069831); expected 358.6 (0.02)
Passed bias filter:                      615  (0.034302); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.45
# Mc/sec: 2681.99
//
Query:       EFC35808.1  [L=124]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-18   66.9   0.0    1.5e-18   66.6   0.0    1.1  1  Hydrolase_like  HAD-hyrolase-like


Domain annotation for each model (and alignments):
>> Hydrolase_like  HAD-hyrolase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.6   0.0   8.6e-23   1.5e-18       2      75 .]      27     115 ..      26     115 .. 0.91

  Alignments for each domain:
  == domain 1  score: 66.6 bits;  conditional E-value: 8.6e-23
                     .STTSSHHHHHHHHHH...............---GGGEEEEES-TTTHHHHHHHCT-EEEEESSSSS-TTTHHHHHHHHT---SEEES- CS
  Hydrolase_like   2 lgKPepemydfalevl...............gsdpeevlmiGDrlatDiagAnnaGwksvLVltGvtrpedleepehkptyvaddlaea 75 
                     +gKP++++yd+a +vl               ++d   +++iGD++ +Di+gAn+aG  s+L +tGv + ++ ++ +  +t+v+++++ea
      EFC35808.1  27 FGKPHKVTYDYAKKVLidqlrsshaghedrdNVDDMTIYAIGDNPLSDIKGANGAGFVSMLLRTGVWQSSEENDSQNPATHVFPSVREA 115
                     69****************9998888766655555666**********************************99999**********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (124 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       392  (0.021864); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.28s 00:00:00.71 Elapsed: 00:00:00.44
# Mc/sec: 852.51
//
Query:       EFC35809.1  [L=191]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-34  119.4   0.3    1.7e-34  119.1   0.3    1.1  1  DEAD           DEAD/DEAH box helicase
    4.9e-05   23.4   0.0    9.2e-05   22.5   0.0    1.3  1  ResIII         Type III restriction enzyme, res subunit
     0.0014   18.0   1.1      0.002   17.5   0.1    1.7  2  CMS1           U3-containing 90S pre-ribosomal complex subuni
     0.0039   17.5   0.1     0.0062   16.9   0.1    1.4  1  AAA_19         AAA domain
      0.005   16.6   0.0     0.0085   15.8   0.0    1.3  1  AAA_30         AAA domain
  ------ inclusion threshold ------
      0.033   14.0   0.0      0.051   13.4   0.0    1.2  1  Helicase_RecD  Helicase


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  119.1   0.3   5.7e-38   1.7e-34       3     135 ..      55     190 ..      53     191 .] 0.94

  Alignments for each domain:
  == domain 1  score: 119.1 bits;  conditional E-value: 5.7e-38
                 HHHHHHHHHH...TTCEEEEEESTTSSHHHHHHHHHHHHHHHSTTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHHTTC CS
                 xxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   3 iQaeaiplil...gggdvlvaaeTGsGKTlaflipvlqivyetkgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskldngv 98 
                 iQ++ai  i       dv+++a+ G+GKT+ f i +lq++  + +  +p+ l+++PtreLa+q+++ + ++++y++++v++++gg++ +++++ l++gv
  EFC35809.1  55 IQQRAILPITtsePPADVIGQAQSGTGKTATFTISLLQRLNISPDVIQPQGLVLAPTRELAQQIHKVIMSLGEYMKVKVHACVGGTKVQHDIAILEEGV 153
                 7888887777443337************************7779******************************************************* PP

                 SEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  99 divvgtpgrlddllstgklnlsqvrflVlDEadrlld 135
                 +i+vgtpgr+++++++g+ln++++++lV+DEad++l+
  EFC35809.1 154 HIIVGTPGRVFHMIQSGHLNVNSIKMLVIDEADEMLS 190
                 ***********************************98 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0   3.1e-08   9.2e-05      24     141 ..      69     185 ..      50     188 .. 0.78

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 3.1e-08
                 TSEEEEEESTTSTHHHHH.HHHHHHH-S.......-EEEEESSHHHHHHHHHHGGGGTGG.........GEEEESSS-B--.......-SEEEEEHHHH CS
      ResIII  24 dkrglikmaTGtGKTlva.aklierllkkgkee..kflflvprkslleqtleefkkflseayke.....igkkvsgdkkkakekdstnkkilvttiqsl 114
                    ++ ++  GtGKT +  ++l +rl  + +    + l+l+p+++l +q  + ++++ +  + +      g+kv+ d  +     ++  +i+v t  ++
  EFC35809.1  69 PADVIGQAQSGTGKTATFtISLLQRLNISPDVIqpQGLVLAPTRELAQQIHKVIMSLGEYMKVKvhacvGGTKVQHDIAIL----EEGVHIIVGTPGRV 163
                 5566667889********89999999887554377****************888777776655544454455555555555....9************* PP

                 HHTH........HHHTTT-SEEEEETG CS
      ResIII 115 dadseeeeeeseellrdrfdviiiDEa 141
                    +     +s +l  +++++++iDEa
  EFC35809.1 164 FHMI-----QSGHLNVNSIKMLVIDEA 185
                 ****.....9999999**********8 PP

>> CMS1  U3-containing 90S pre-ribosomal complex subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.2      0.45   1.3e+03      23      43 ..      15      35 ..       4      44 .. 0.59
   2 !   17.5   0.1   6.8e-07     0.002     165     209 ..     141     184 ..     102     186 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.45
        CMS1 23 kkRskkkerkkgklketqDvk 43
                k++s k++ +++++ke +D++
  EFC35809.1 15 KQKSGKARYEQKEVKEFDDMN 35
                344555555555555555543 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 6.8e-07
        CMS1 165 kleesvtylkksrigiavGtpgRildLleeeslsvdeLkrivlDa 209
                 k++ +++ l    + i vGtpgR+ ++++ + l+v+++k +v+D 
  EFC35809.1 141 KVQHDIAILE-EGVHIIVGTPGRVFHMIQSGHLNVNSIKMLVIDE 184
                 6666666665.458999**************************95 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.1   2.1e-06    0.0062       3     113 ..      58     187 ..      56     190 .. 0.59

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 2.1e-06
      AAA_19   3 eav.e.alkekvllvtaGp..GtGKTrvlkhiv.allvelggvkpeeillvaftgrAakelrerlaalgae...........atTiHrlalldfddllt 85 
                 +a+   +++e++  v++ +  GtGKT + +  + + l+   +v   + l++a+t+  a+++++ + +lg+            ++  H +a+        
  EFC35809.1  58 RAIlPiTTSEPPADVIGQAqsGTGKTATFTISLlQRLNISPDVIQPQGLVLAPTRELAQQIHKVIMSLGEYmkvkvhacvggTKVQHDIAI-------- 148
                 444345666677777755433*****9987654144444445555899***************9977766665555555555344444433........ PP

      AAA_19  86 ealelle................eaeeekklqeeellivDEfqd 113
                      le                 ++ + ++++ ++l++DE+ +
  EFC35809.1 149 -----LEegvhiivgtpgrvfhmIQSGHLNVNSIKMLVIDEADE 187
                 .....233333333444444444224555665666999999865 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   2.8e-06    0.0085       6      97 ..      56     185 ..      53     190 .. 0.64

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.8e-06
      AAA_30   6 Qaaavealltsgdrv.avltGpAGtGKtta..lkalreaweaag...grviglAptgkaAkvLae...elg.ieastiakllkrlk............. 81 
                 Q++a+  ++ts+    ++ ++  GtGKt +  ++ l+++  +      + ++lApt + A+++ +   +lg      ++  +  +k             
  EFC35809.1  56 QQRAILPITTSEPPAdVIGQAQSGTGKTATftISLLQRLNISPDviqPQGLVLAPTRELAQQIHKvimSLGeYMKVKVHACVGGTKvqhdiaileegvh 154
                 6666666666665551566999*****876114455544443335667788*************64442222122233333333334555556666777 PP

      AAA_30  82 ...............grarlepgtllivDEa 97 
                                g+ ++++ ++l++DEa
  EFC35809.1 155 iivgtpgrvfhmiqsGHLNVNSIKMLVIDEA 185
                 77777778888887977889999*******9 PP

>> Helicase_RecD  Helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   1.7e-05     0.051       4      99 ..      76     185 ..      73     189 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.7e-05
  Helicase_RecD   4 AdRGRGKSaalGlalaaliaegk....snilvtapskenvktlfeflakglealglke.........eekkkkaekaelrvr.......kqrieyi 79 
                    A+ G+GK+a+  + l + ++ +      + lv ap++e ++++ + + +  e +++k          +   ++    ++  +            ++
     EFC35809.1  76 AQSGTGKTATFTISLLQRLNISPdviqPQGLVLAPTRELAQQIHKVIMSLGEYMKVKVhacvggtkvQ---HDI---AILEEgvhiivgTPGRVFH 165
                    899**********999999888767777889**************99887777777767776653221...221...2222245566765556677 PP

  Helicase_RecD  80 apdellklkeqadllvvDEA 99 
                    + ++ + + ++ ++lv+DEA
     EFC35809.1 166 MIQSGHLNVNSIKMLVIDEA 185
                    777777777789*******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       548  (0.030565); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1259.46
//
Query:       EFC35810.1  [L=524]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.6e-23   82.0   0.2    4.6e-23   82.0   0.2    2.2  3  AAA-ATPase_like  Predicted AAA-ATPase
  ------ inclusion threshold ------
       0.13   12.0   0.2       0.59    9.9   0.0    2.2  2  RecO_N_2         RecO N terminal


Domain annotation for each model (and alignments):
>> AAA-ATPase_like  Predicted AAA-ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.0   0.2   5.1e-27   4.6e-23     106     279 ..       8     191 ..       1     192 [. 0.79
   2 ?   -1.3   0.1      0.13   1.2e+03      94     133 ..     339     378 ..     316     404 .. 0.77
   3 ?   -3.2   0.2      0.49   4.4e+03     236     236 ..     473     473 ..     433     508 .. 0.47

  Alignments for each domain:
  == domain 1  score: 82.0 bits;  conditional E-value: 5.1e-27
  AAA-ATPase_like 106 lkelekefgkkke....ekslakrlkelieraaektgkkvvvLiDEYDkpilealeee.elaeelre.........flrefykvlkk.adeylk 184
                      ++  ++ +g   e    +++  ++ ++li+ + +++g k++vLiDEYD++ ++++ e+ e ++ + e          +r+f++ lk+ + + l+
       EFC35810.1   8 IEGFLECYGMGGEvsinQNDSFDTYQKLIQLLVKRKG-KLMVLIDEYDRFANKLIFENpEKYQLIVEgkrgdptssPIRSFFERLKEsSATGLQ 100
                      4444444444444444466777778888887776655.7899***********987665777777777888999889**********7555565 PP

  AAA-ATPase_like 185 ..fvfltGvskvtkdsifSglnnlkdisldekysallGfteeeveellkeeleelalkeatveelieelkewYdgYsFaeeseesvyNpfsvln 276
                        + ++tG+++++  +  Sg+n  ++is d+ +  l+Gfte++++  l+++ + + +   + + +i+++k++Y gY+F   s+++++N +  + 
       EFC35810.1 101 dfRSIITGITPIALAD-ASGYNVSSNISSDKIFGGLVGFTENDLRMALNNI-DIIGN---DQDITISTMKKYYKGYHF-PGSKHALFNTTLSMF 188
                      34679**********9.7*******************************99.33433...56899*************.56778*****99999 PP

  AAA-ATPase_like 277 llk 279
                      +l+
       EFC35810.1 189 FLN 191
                      887 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.13
  AAA-ATPase_like  94 seeeleeslkeklkelekefgkkkeekslakrlkeliera 133
                      ++++l++ l ++l+++e+ f+++ +e+sl++++++ +++ 
       EFC35810.1 339 TQDNLKKLLWSILSKQETVFDNDMSERSLQSCIESALRSY 378
                      5677788888888888888888888888877777776654 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 0.49
  AAA-ATPase_like 236 e 236
                      +
       EFC35810.1 473 K 473
                      1 PP

>> RecO_N_2  RecO N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   6.6e-05      0.59      14      42 ..     155     183 ..     146     191 .. 0.85
   2 ?   -2.8   0.1      0.61   5.5e+03      13      29 ..     235     251 ..     231     255 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 6.6e-05
    RecO_N_2  14 edlivtiltkeklktlyrfyGarhsliql 42 
                 +d  +ti t +k +++y f G +h+l + 
  EFC35810.1 155 NDQDITISTMKKYYKGYHFPGSKHALFNT 183
                 56679*******************98775 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.61
    RecO_N_2  13 dedlivtiltkeklktl 29 
                 ++d+i ++l+k+ ++++
  EFC35810.1 235 SNDIIQQLLSKDYIEVT 251
                 68999999999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (524 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1128  (0.0629148); expected 358.6 (0.02)
Passed bias filter:                      541  (0.0301746); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.29s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 3034.09
//
Query:       EFC35811.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.034   13.9   1.0      0.073   12.9   1.0    1.5  1  Synaptobrevin  Synaptobrevin


Domain annotation for each model (and alignments):
>> Synaptobrevin  Synaptobrevin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   1.0   4.1e-06     0.073       3      52 ..      45      94 ..      44     107 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.1e-06
                   XHHHHHHHHHHCCCCHHCCHHHHCHCCCCCHHHHCCCCHHHHHHHHHHHH CS
  Synaptobrevin  3 dklakikaevdevkdimkeNidkvlergekldeLvdktenLqssaqqFkk 52
                   +++++i +++++ k+ +++N ++  e ++++d+L++  + L ++a+++++
     EFC35811.1 45 NNTQTISTNLNQYKERIINNDQQQYEDNDDIDDLDEDGDVLMAEANTYQQ 94
                   67899*******************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       981  (0.0547158); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1757.27
//
Query:       EFC35812.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-31  110.0  14.7    1.3e-31  109.8  14.7    1.0  1  Calreticulin  Calreticulin family


Domain annotation for each model (and alignments):
>> Calreticulin  Calreticulin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.8  14.7   7.2e-36   1.3e-31     193     312 ..       8     122 ..       2     123 .] 0.94

  Alignments for each domain:
  == domain 1  score: 109.8 bits;  conditional E-value: 7.2e-36
  Calreticulin 193 eppvnppkeidDpedkkPedWddrekipDpeavkPedwdek...apekipdpeavkPedWledepelipdpeaekPedwdeeedgeweaplikNpkC 286
                   +p+v+p+keidDp+dkkP  W+d+e ++Dpea+k edwde+   ++e+i dpe+++ edWle+e+++ipd ea+   +wde+edg we+p++ N+kC
    EFC35812.1   8 SPSVVPSKEIDDPTDKKPLGWVDEELMDDPEASKLEDWDETlsrEEEFISDPEDNMLEDWLENEQDMIPDSEAKM-LEWDEDEDGAWETPIVGNKKC 103
                   89**************************************8777999***********************99876.79******************* PP

  Calreticulin 287 eeasgCgkwkpplikNpkYkGkwkap 312
                   e        +p+likNp+Y+Gkw a+
    EFC35812.1 104 E-------TQPRLIKNPAYRGKWVAR 122
                   *.......589************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       443  (0.0247086); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.32s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 733.81
//
Query:       EFC35813.1  [L=834]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (834 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1285  (0.0716716); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.49
# Mc/sec: 5076.44
//
Query:       EFC35814.1  [L=234]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-26   91.4   0.4    7.2e-26   90.5   0.4    1.3  1  DYW_deaminase  DYW family of nucleic acid deaminases
    4.2e-06   26.6   0.1      0.017   15.3   0.0    3.0  3  PPR            PPR repeat
    0.00073   19.7   0.0     0.0058   16.8   0.0    2.4  2  PPR_2          PPR repeat family


Domain annotation for each model (and alignments):
>> DYW_deaminase  DYW family of nucleic acid deaminases
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.5   0.4   1.2e-29   7.2e-26      12     121 ..     117     227 ..     110     229 .. 0.87

  Alignments for each domain:
  == domain 1  score: 90.5 bits;  conditional E-value: 1.2e-29
  DYW_deaminase  12 vvkfasgdkahpeskeieekleelsqrllsig.yapdlekalh.dvk.eeekekkplllsHsEKlalaygllktesgaqiriiknlrvCeDChsaf 104
                    v +f+s d  h e++ i+++l+ l  +ll++  y pd++     d++ eeeke  ++l++H EKla+aygl+ +++g+++ i+ nlrvC+DCh+a+
     EFC35814.1 117 VITFVSEDDKHKEINLIRAELDTLRLELLESKlYHPDTSLGMKkDITtEEEKE--KVLFQHCEKLAIAYGLISLPKGSTLCITANLRVCGDCHQAA 210
                    689**********************9997766266777765443555144454..5**************************************** PP

  DYW_deaminase 105 kliskilkaeivvrdae 121
                    k iski++++i+vrd +
     EFC35814.1 211 KAISKIRECDIIVRDGN 227
                    ***************65 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   2.9e-06     0.017       3      28 ..      12      37 ..      10      39 .. 0.91
   2 !    8.0   0.0    0.0006       3.6       4      20 ..      49      65 ..      48      70 .. 0.88
   3 ?   -2.6   0.0       1.5   9.2e+03       2      24 ..      77      99 ..      76     103 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 2.9e-06
         PPR  3 ynslIsgycknGkleeAlelfkeMke 28
                 ++++++++++G+++e +++++ M+ 
  EFC35814.1 12 VSAVLNACSHSGLIKEGFQIYESMQT 37
                5899********************86 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0006
         PPR  4 nslIsgycknGkleeAl 20
                +++I+ ++++G leeA 
  EFC35814.1 49 TCIIDMLGRAGFLEEAH 65
                689*************6 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.5
         PPR  2 tynslIsgycknGkleeAlelfk 24
                ++ +l+ +  k +++e  +  f+
  EFC35814.1 77 IWMTLLGASRKYNNIEFGEVAFE 99
                68888887777777666655555 PP

>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   9.7e-07    0.0058       4      47 ..      10      54 ..       7      57 .. 0.84
   2 ?    0.5   0.0      0.12     7e+02       7      22 ..      49      64 ..      47      67 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 9.7e-07
       PPR_2  4 vtyNtlIsglckkgkveeAfklfneMkkr.glePnsyTysilikg 47
                ++  ++++++ + g ++e f++++ M+ +  +eP+ +  + +i+ 
  EFC35814.1 10 FVVSAVLNACSHSGLIKEGFQIYESMQTNhDIEPDIKHKTCIIDM 54
                566799**********************65*****8766666665 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.12
       PPR_2  7 NtlIsglckkgkveeA 22
                +++I++l ++g +eeA
  EFC35814.1 49 TCIIDMLGRAGFLEEA 64
                689************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (234 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       621  (0.0346366); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1441.64
//
Query:       EFC35815.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-19   70.0   1.8    4.3e-07   30.0   0.1    4.4  4  PPR_2     PPR repeat family
    9.7e-19   66.2   6.9      5e-06   26.4   0.1    5.8  6  PPR       PPR repeat
    1.6e-08   34.5   0.8      7e-05   22.8   0.0    4.1  4  PPR_3     Pentatricopeptide repeat domain
  ------ inclusion threshold ------
       0.03   14.0   0.1        3.4    7.5   0.0    3.5  4  PPR_1     PPR repeat


Domain annotation for each model (and alignments):
>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0   0.00064       2.9       1      30 [.     119     148 ..     119     151 .. 0.92
   2 !    8.3   0.0    0.0006       2.7       2      32 ..     176     206 ..     175     208 .. 0.91
   3 !   30.0   0.1   9.7e-11   4.3e-07       3      48 ..     208     252 ..     206     254 .. 0.94
   4 !   20.0   0.0   1.3e-07   0.00058       6      39 ..     277     310 ..     275     318 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00064
       PPR_2   1 pdvvtyNtlIsglckkgkveeAfklfneMk 30 
                 pd + y ++I++l++ +++++A+   +eM+
  EFC35815.1 119 PDKFHYSCYIKALVNTKQIQKALIAVSEMR 148
                 77889******************9999997 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0006
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkr 32 
                 d+++ ++lIs++ k g +e  ++l + M+k+
  EFC35815.1 176 DIIVQTSLISMFSKCGLLERSIELXHSMEKK 206
                 6777799*********************997 PP

  == domain 3  score: 30.0 bits;  conditional E-value: 9.7e-11
       PPR_2   3 vvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikgl 48 
                 + t+N+++s+++++  ++e + lf+eM+  ++e +  T+s++i +l
  EFC35815.1 208 TATWNAMLSAYAHHSLYNEVLLLFSEME-SSIETDKQTFSYVILAL 252
                 68*************************8.89************887 PP

  == domain 4  score: 20.0 bits;  conditional E-value: 1.3e-07
       PPR_2   6 yNtlIsglckkgkveeAfklfneMkkrglePnsy 39 
                 y +lI+g+ +  ++ +A+ +++ Mk++ ++Pns 
  EFC35815.1 277 YHALIKGCINSSNFTQALNVLELMKSNRIPPNSR 310
                 889*****************************86 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.6   7.3e+03      16      24 ..      69      77 ..      68      80 .. 0.85
   2 !    5.8   0.0    0.0041        18       2      28 ..     123     149 ..     122     150 .. 0.92
   3 !   14.4   0.0   7.8e-06     0.035       4      29 ..     181     206 ..     181     207 .. 0.95
   4 !   26.4   0.1   1.1e-09     5e-06       2      28 ..     210     236 ..     209     237 .. 0.95
   5 ?    4.3   0.0     0.013        58       2      23 ..     244     265 ..     243     267 .. 0.92
   6 !   14.4   0.0   7.7e-06     0.034       2      30 ..     276     304 ..     275     305 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.6
         PPR 16 leeAlelfk 24
                +ee+ ++fk
  EFC35815.1 69 VEECDKIFK 77
                799999998 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0041
         PPR   2 tynslIsgycknGkleeAlelfkeMke 28 
                  y++ I++++   ++++Al    eM+ 
  EFC35815.1 123 HYSCYIKALVNTKQIQKALIAVSEMRG 149
                 799**********************86 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 7.8e-06
         PPR   4 nslIsgycknGkleeAlelfkeMkek 29 
                 +slIs ++k+G+le  +el + M++k
  EFC35815.1 181 TSLISMFSKCGLLERSIELXHSMEKK 206
                 79*********************986 PP

  == domain 4  score: 26.4 bits;  conditional E-value: 1.1e-09
         PPR   2 tynslIsgycknGkleeAlelfkeMke 28 
                 t+n+++s+y+++ ++ e+l lf eM++
  EFC35815.1 210 TWNAMLSAYAHHSLYNEVLLLFSEMES 236
                 9************************97 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.013
         PPR   2 tynslIsgycknGkleeAlelf 23 
                 t++ +I ++++ Gk++ Al+++
  EFC35815.1 244 TFSYVILALSSLGKYQNALQIL 265
                 89999**************986 PP

  == domain 6  score: 14.4 bits;  conditional E-value: 7.7e-06
         PPR   2 tynslIsgycknGkleeAlelfkeMkekG 30 
                  y +lI+g+  + ++  Al +++ Mk++ 
  EFC35815.1 276 HYHALIKGCINSSNFTQALNVLELMKSNR 304
                 699***********************987 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.27   1.2e+03      16      42 ..     122     148 ..     118     151 .. 0.83
   2 !    4.2   0.0    0.0098        44      10      60 ..     172     218 ..     166     221 .. 0.86
   3 ?    2.0   0.0     0.048   2.2e+02       5      39 ..     233     266 ..     229     271 .. 0.84
   4 !   22.8   0.0   1.6e-08     7e-05      18      59 ..     277     318 ..     275     322 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.27
       PPR_3  16 vtYthLLtayanagnkklalevlermk 42 
                   Y   ++a +n++  + al  + +m+
  EFC35815.1 122 FHYSCYIKALVNTKQIQKALIAVSEMR 148
                 56778899999**99999999999997 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0098
       PPR_3  10 gikldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvi 60 
                 g+  d++  t+L++ + + g +++  e    m+kk   Pt  t+Na+l+++
  EFC35815.1 172 GFFNDIIVQTSLISMFSKCGLLERSIELXHSMEKK---PT-ATWNAMLSAY 218
                 667799999***********************996...76.5899999988 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.048
       PPR_3   5 emerkgikldvvtYthLLtayanagnkklalevle 39 
                 eme   i+ d  t+   + a    g+++ al++l 
  EFC35815.1 233 EME-SSIETDKQTFSYVILALSSLGKYQNALQILT 266
                 554.359999999999999**************85 PP

  == domain 4  score: 22.8 bits;  conditional E-value: 1.6e-08
       PPR_3  18 YthLLtayanagnkklalevlermkkkgikPtvvtyNailgv 59 
                 Y +L+++++n  n   al+vle mk ++i P+   + +++++
  EFC35815.1 277 YHALIKGCINSSNFTQALNVLELMKSNRIPPNSRIFISLMKT 318
                 99********************************99999997 PP

>> PPR_1  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.92   4.1e+03       5      16 ..     119     130 ..     118     131 .. 0.80
   2 ?    7.5   0.0   0.00075       3.4      11      34 .]     181     204 ..     172     204 .. 0.92
   3 ?    2.0   0.0     0.038   1.7e+02       9      34 .]     210     235 ..     208     235 .. 0.87
   4 ?   -1.6   0.0      0.51   2.3e+03      12      34 .]     279     301 ..     276     301 .. 0.63

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.92
                 --HHHHHHHHHH CS
       PPR_1   5 PdvvTYNtLIdG 16 
                 Pd + Y++ I++
  EFC35815.1 119 PDKFHYSCYIKA 130
                 9*****986665 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.00075
                 HHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1  11 NtLIdGlCkaGrvdeAfelfdeMe 34 
                 ++LI+ + k+G++++ +el   Me
  EFC35815.1 181 TSLISMFSKCGLLERSIELXHSME 204
                 79*****************99996 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.038
                 HHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   9 TYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 T+N +++++  + + +e + lf+eMe
  EFC35815.1 210 TWNAMLSAYAHHSLYNEVLLLFSEME 235
                 99*****9999999999899999996 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 0.51
                 HHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1  12 tLIdGlCkaGrvdeAfelfdeMe 34 
                  LI+G+    +   A+ +++ M+
  EFC35815.1 279 ALIKGCINSSNFTQALNVLELMK 301
                 56666555555667888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       661  (0.0368676); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.25s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2222.30
//
Query:       EFC35816.1  [L=569]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00033   20.5   0.0    0.00084   19.2   0.0    1.6  1  Phage_integrase  Phage integrase family
  ------ inclusion threshold ------
       0.05   12.2   5.9      0.058   11.9   5.9    1.2  1  Macoilin         Macoilin family


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   9.3e-08   0.00084      34     169 ..     404     550 ..     391     552 .. 0.82

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 9.3e-08
                      T--HHHHTT-BGGG.EECTTTEEEEE...........EEECSSSSEEEEECT...HHHHHHHHHHHHHHCHCCTTTSBSSBETTSSB--HHHHH CS
  Phage_integrase  34 GlRisEllsLrvkd.ldlengvilvh...........eregKgskeravpls...eealellkellskaleeaeksellfaskrgkplsrqtvr 112
                       +R +El++L+++   +l+ng i+++           e+ ++  k    +l       ++ll +++++    ++ ++ lf  +++   ++++v+
       EFC35816.1 404 FARPGELARLKWGYvTKLRNGNIKLDlsghktdffllEKPITIDK----HLEnpsVCPVKLLFDYMNTVQHFKKADSPLFSLQDNIFFNTEDVS 493
                      57999********97789999999984444444444333333333....3333335678999999999999999999***************** PP

                      HHHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHHHHT-SSCCHHHHHHCC CS
  Phage_integrase 113 kafkraveeagiekpltpHtlRhsfataLleagvdlrvvqkllGHssisttqiYthv 169
                      + +k+a    + e  +++H+lR  + t+ + +g++++ + +   H+++++ q Y + 
       EFC35816.1 494 QLIKNAMFSVDSEITVSGHSLRIGATTESIIKGIPTQDIIMGTRHKDVKSLQPYQRQ 550
                      *********999999*************************************99875 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   5.9   6.5e-06     0.058     235     349 ..       3     118 ..       1     340 [. 0.50

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 6.5e-06
    Macoilin 235 sknnhslnkkdsslklpeleyrekkksakssrsdskkkhehn...esvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnkn 330
                 +k+ ++ ++++s ++lp +e +  ++  k+++++++kk ++    + v ++ ++k+ ++  s++  l    s+  +s+ll ++   ++ss++ sssn++
  EFC35816.1   3 AKKPQDIDSSSSDEDLPAVEVEYPTTPVKARKQQAAKKLRKLkamSPVANRNKRKQSTSVSSSNSALDDGISTVVSSSLLSNSTLLDSSSTAPSSSNNS 101
                 566666666677777777766666555555544444443322222222222222222222222222222223333333333333333333333332222 PP

    Macoilin 331 skkasagsagssnssskkh 349
                 s+++s+    s  sss +h
  EFC35816.1 102 SSSNSGRD--SFASSSSEH 118
                 22222221..222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (569 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1135  (0.0633053); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.34s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 3296.33
//
Query:       EFC35817.1  [L=275]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-09   37.2   3.4    0.00072   19.5   0.1    4.2  5  NHL       NHL repeat
  ------ inclusion threshold ------
      0.065   12.0   0.1      0.093   11.5   0.1    1.1  1  RHSP      Retrotransposon hot spot protein


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       1.9   1.7e+04       9      17 ..      38      46 ..      38      48 .. 0.82
   2 !   12.3   0.3   1.5e-05      0.14      11      27 ..     101     117 ..      99     118 .. 0.88
   3 ?   -2.5   0.0      0.75   6.8e+03       1      10 [.     192     201 ..     192     202 .. 0.78
   4 ?    3.3   0.0     0.011        95      15      27 ..     210     222 ..     209     223 .. 0.88
   5 !   19.5   0.1   8.1e-08   0.00072       1      27 [.     244     271 ..     244     272 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 1.9
                EETTTEEEE CS
         NHL  9 vdsnGdiyV 17
                vd+ G i++
  EFC35817.1 38 VDKEGKIVI 46
                788999987 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 1.5e-05
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                  ++ ++VaD++nh +++
  EFC35817.1 101 RDNVVFVADNYNHAIKI 117
                 5899**********986 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.75
                 BSSEEEEEEE CS
         NHL   1 fnyPhGvavd 10 
                 +++P G+++d
  EFC35817.1 192 LYSPFGICID 201
                 567889**97 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.011
                 EEEEECCCTEEEE CS
         NHL  15 iyVaDsenhrvqv 27 
                 ++V+Ds+++++++
  EFC35817.1 210 LIVSDSYHSSLKI 222
                 89*******9987 PP

  == domain 5  score: 19.5 bits;  conditional E-value: 8.1e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 f +P G++++  + +i+  D++n+r+qv
  EFC35817.1 244 FHHPYGLCYNrRQQEILLVDRNNSRIQV 271
                 77899**********************9 PP

>> RHSP  Retrotransposon hot spot protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1     1e-05     0.093     182     240 ..     105     170 ..      96     184 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1e-05
        RHSP 182 vtfyedeedavkaveelar...enlkGyiiydvgkdldtPaPldpPegw....avivlasPdkksy 240
                 v    ++++a+k+v  +     + +  y+ y +gk+++   P    + +    + +++asPdk++ 
  EFC35817.1 105 VFVADNYNHAIKIVSTVDGsilQSITRYVSYSLGKEIHVKNPNIVNVECftkfGEVIIASPDKNNI 170
                 344568999999999887767789999***********99997766654333388********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       465  (0.0259356); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 1901.53
//
Query:       EFC35818.1  [L=109]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0031   17.0   0.3     0.0038   16.7   0.3    1.2  1  DUF851      Protein of unknown function (DUF851)
  ------ inclusion threshold ------
      0.041   14.0   0.9      0.043   13.9   0.9    1.2  1  Pkip-1      Pkip-1 protein
      0.077   13.2   0.0        1.6    9.0   0.0    2.1  2  Requiem_N   N-terminal domain of DPF2/REQ.
       0.11   12.7   0.0        2.1    8.5   0.0    2.1  2  Ig_GlcNase  Exo-beta-D-glucosaminidase Ig-fold domain


Domain annotation for each model (and alignments):
>> DUF851  Protein of unknown function (DUF851)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.3   8.5e-07    0.0038       9      62 ..      24      79 ..      16      99 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 8.5e-07
      DUF851  9 knrevdekemerllkklkeekkqskkitlpldekskllmdrvvKkpy..plkyskk 62
                ++ e+++++++r+l  + ee  + +++t +ld+k+k+++d+ v   y  p ky++ 
  EFC35818.1 24 NELEIENATIKRVLPLMLEEDFEKRPTTNDLDDKTKIIIDKEVDDYYenPNKYKRY 79
                57799************9***********************887766335677554 PP

>> Pkip-1  Pkip-1 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.9   9.6e-06     0.043      52     117 ..       2      67 ..       1      98 [. 0.82

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 9.6e-06
      Pkip-1  52 leaLesenasdkek.ldfvndlsdLdlsneeieslletkendeflkkkykaaklleaiqkifdknak 117
                 le+L ++++++ e+  + v+ l++L+++n+ i+++l     +e + k++ + +l+++ + i+dk+  
  EFC35818.1   2 LEVLSRKRIRNLENhSNVVQCLNELEIENATIKRVLP-LMLEEDFEKRPTTNDLDDKTKIIIDKEVD 67 
                 5677787777766637777777**************8.666779******************97654 PP

>> Requiem_N  N-terminal domain of DPF2/REQ.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0     0.057   2.5e+02      24      39 ..       7      22 ..       5      34 .. 0.83
   2 ?    9.0   0.0   0.00036       1.6      22      45 ..      74      97 ..      72     103 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.057
   Requiem_N 24 klRlpflDsqTgvaqr 39
                ++R+++l+++++v q 
  EFC35818.1  7 RKRIRNLENHSNVVQC 22
                68**********9985 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00036
   Requiem_N 22 eRklRlpflDsqTgvaqrecelwm 45
                ++ +R+p+l++ T ++ ++c+l+ 
  EFC35818.1 74 NKYKRYPNLNHLTPISEEDCKLVQ 97
                5779****************9975 PP

>> Ig_GlcNase  Exo-beta-D-glucosaminidase Ig-fold domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0   0.00047       2.1      38      69 ..      12      43 ..       6      45 .. 0.90
   2 ?    2.2   0.0     0.044     2e+02       2      22 ..      69      89 ..      68     108 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00047
  Ig_GlcNase 38 tLenkssvpAffvrlnlvdaageevlPvlwsD 69
                +Len+s+v+  +++l++ +a+ ++vlP + ++
  EFC35818.1 12 NLENHSNVVQCLNELEIENATIKRVLPLMLEE 43
                79*************************99876 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.044
  Ig_GlcNase  2 yytpvtkyadytaLnkLpkak 22
                yy   +ky+ y +Ln+L + +
  EFC35818.1 69 YYENPNKYKRYPNLNHLTPIS 89
                788899**********99865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 696.66
//
Query:       EFC35819.1  [L=108]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.017   14.4   0.2       0.02   14.2   0.2    1.1  1  DUF5050   Domain of unknown function (DUF5050)


Domain annotation for each model (and alignments):
>> DUF5050  Domain of unknown function (DUF5050)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.2   1.1e-06      0.02     195     254 ..      33      92 ..      21     100 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.1e-06
                 GTT-EEEE-SSS---EE-S-S-EEEEEEETTEEEEEE-SSS-E.EEEEETTS---EEEEE CS
     DUF5050 195 knyaLyrvklsgsekevltedkvdnyNvtgnwiYyqkesdeekalyrikldGsekeklae 254
                 +n ++  v+++gse e+ t+d +  +   g+++Y  +++d++ +  ++ l+G + + +++
  EFC35819.1  33 HNSTISSVTIKGSEYEITTNDGACRFVRIGEIVYIEQNKDKKTKYAKMALEGRKITWITH 92 
                 7899999999****999999998888888999**99999999999999999999888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       731  (0.0407719); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.30s 00:00:00.74 Elapsed: 00:00:00.48
# Mc/sec: 682.70
//
Query:       EFC35820.1  [L=281]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0032   18.4   0.0     0.0069   17.3   0.0    1.6  1  Trypsin_2  Trypsin-like peptidase domain


Domain annotation for each model (and alignments):
>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.9e-07    0.0069       1     139 [.      48     253 ..      48     262 .. 0.58

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.9e-07
   Trypsin_2   1 GsGflvgsdglilTnaHvvdsadgaav........................kaikkkveeagadgrevpakvvaadp........el.DlAllkvssde 66 
                 GsGf++ ++  i+Tn Hv ++ ++  +                         + k   ++  ++   v+ ++v++dp        +  D++ + + s++
  EFC35820.1  48 GSGFYILPNT-IITNSHVANEIESIGKvnaynnswninstisgmpkkletlFSGKAIKYFQMEKSFPVTQNWVGRDPitttvgnfDFfDITAMNF-SGS 144
                 9*********.********5555555544444233233333222222222222222333333355555666999999998887554489******.888 PP

   Trypsin_2  67 raglpplplgpsealkggepvyvvGyplggeksg........................................svssGivsgvvesesaasgegesfl 125
                 ++++ ++p    + l++ ++++ ++yp+ ++k++                                         +++G v +v++  +++  ++e++ 
  EFC35820.1 145 PNKVFFIPSP--RILQPNDEIITLSYPGDENKPPfsssqnyvdwapsesflkdnifngygtlcasvgkilhpydFTQNGLVEKVED-FCYDKSNQECLA 240
                 8888888833..36677779******866666556555555666666655555555555555444444444444444444444444.555555555554 PP

   Trypsin_2 126 qtdaatspGsSGGp 139
                    + +  GsSGG 
  EFC35820.1 241 SSESLI-FGSSGGV 253
                 444433.3666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (281 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       301  (0.0167884); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1807.22
//
Query:       EFC35821.1  [L=524]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    9.9e-24   83.9   0.4    1.4e-23   83.4   0.4    1.2  1  p450       Cytochrome P450
  ------ inclusion threshold ------
      0.034   13.7   1.1       0.16   11.6   0.0    2.8  3  EF-hand_1  EF hand
      0.045   14.1   0.0       0.14   12.4   0.0    1.8  1  C2         C2 domain
      0.076   13.0   0.1        1.8    8.7   0.0    3.3  3  EF-hand_6  EF-hand domain
       0.18   11.3   1.1       0.47   10.0   0.1    2.2  2  EF-hand_5  EF hand


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.4   0.4     4e-27   1.4e-23      35     276 ..     276     524 .]     259     524 .] 0.89

  Alignments for each domain:
  == domain 1  score: 83.4 bits;  conditional E-value: 4e-27
                 SEEEEEETT.EEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHHTSHSTT.THHHHHHHHHHHHHHHHHC CS
        p450  35 pifrlklgs.kpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltptltsfgkl.sleelveeeaedlveklrk 131
                 ++++++lg+  ++++ ++ ++++e+l+kk + +s+    +l++    +  +   + +n + w+k+R++ +p + s+  l ++  ++ ee +++++ +++
  EFC35821.1 276 KVVKIQLGTfSQIHISNDENLIREILVKKYKTVSK---GNLFEPVGIFGPNIFSADSNDPIWRKHRTLANPIFSSSSHLkNVFRVTLEECKKMIKFWKS 371
                 78899999867788888999*********766555...467776443445555555555*****************77789****************** PP

                 CCCHCS.....EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHHH CS
        p450 132 kagess.....elditellskaaldvigsilFgarfdlledeklselvkaveelssllskssvqllllfpllkylptkllrklkeavkklkdlldklie 225
                   g+ s     +++i++ l  ++ldvi++++F   ++ + d+++   +   + +++ll+   ++++l++ l+ ++p  +++++k+a +k+k+ +  +ie
  EFC35821.1 372 IYGSESdgtirKVNISNELKSITLDVINRVAFDYDVG-IFDKDAAHRDGIHDWINNLLNGLIYNFVLPKYLFEIIPFGFFKRYKDAKEKFKQATYSMIE 469
                 99999999*****************************.99998989999999999999999999999999***************************** PP

                 HHHHCHCHC...SCSSCSHHHHHHHHC..TTCTCTSSSSHHHHHHHHHHHHHHHHH CS
        p450 226 erretldsa...kksrrdfldalllak..kekkgesklsdeelaatvlellfaGvd 276
                 ++++++d++   +k++ d+l +ll+++   +k++ +kls+ el   ++ +lfaG++
  EFC35821.1 470 KKQQEFDDHtylEKDDEDLLTLLLKSSaaATKEE-EKLSKSELLSAIFIVLFAGFE 524
                 ************99*************9655555.5******************87 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       3.2   1.1e+04      20      28 ..     149     157 ..     149     158 .. 0.79
   2 ?   11.6   0.0   4.5e-05      0.16       5      22 ..     180     197 ..     176     201 .. 0.88
   3 ?   -2.4   0.0       1.3   4.7e+03      17      27 ..     357     367 ..     356     367 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3.2
                 HHHHHHHHH CS
   EF-hand_1  20 eEfkellkk 28 
                 eEf+++l +
  EFC35821.1 149 EEFISFLVS 157
                 799999876 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 4.5e-05
                 HHHHHTTTSSSEEEHHHH CS
   EF-hand_1   5 iFrefDkDgdGkIdfeEf 22 
                  ++++D ++d k++++Ef
  EFC35821.1 180 YWMMADENNDNKLSIQEF 197
                 5899*************9 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 1.3
                 EEHHHHHHHHH CS
   EF-hand_1  17 IdfeEfkellk 27 
                 +++eE k+++k
  EFC35821.1 357 VTLEECKKMIK 367
                 78999999875 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.9e-05      0.14      54      96 ..     196     238 ..     194     246 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.9e-05
                 EEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHH CS
          C2  54 tfevaeleeakLeveVfdndrlskddfiGkveiplstllsgee 96 
                 +f+va +  a L+++++d++++s d+f+ +  ip++ l +g+ 
  EFC35821.1 196 EFDVAAPDLANLQISIWDKNKVSADKFVCENIIPVTALREGSL 238
                 577888889**************************99777665 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0    0.0005       1.8       3      22 ..     178     197 ..     177     201 .. 0.87
   2 ?   -1.2   0.0      0.78   2.8e+03      17      27 ..     357     367 ..     356     369 .. 0.88
   3 ?   -3.2   0.0       3.3   1.2e+04      16      26 ..     505     515 ..     505     516 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0005
   EF-hand_6   3 reaFklfDkdgdGkidaeEl 22 
                 ++ +++ D ++d+k++++E+
  EFC35821.1 178 MRYWMMADENNDNKLSIQEF 197
                 5678999************9 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.78
   EF-hand_6  17 idaeElrkalr 27 
                 ++ eE++k+++
  EFC35821.1 357 VTLEECKKMIK 367
                 899*****997 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 3.3
   EF-hand_6  16 kidaeElrkal 26 
                 k++++El +a+
  EFC35821.1 505 KLSKSELLSAI 515
                 6899***9886 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.1   0.00013      0.47       7      21 ..     183     197 ..     182     199 .. 0.92
   2 ?   -2.5   0.1       1.2   4.3e+03      15      21 ..     505     511 ..     505     513 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00013
                 HH-SS-SSCE-HHHH CS
   EF-hand_5   7 aiDlNgDGkIskeEL 21 
                 ++D N+D k+s++E+
  EFC35821.1 183 MADENNDNKLSIQEF 197
                 58************9 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.2
                 CE-HHHH CS
   EF-hand_5  15 kIskeEL 21 
                 k+sk+EL
  EFC35821.1 505 KLSKSEL 511
                 79****9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (524 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1060  (0.0591221); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.41
# Mc/sec: 3802.97
//
Query:       EFC35822.1  [L=206]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      2e-18   66.9   0.1    5.6e-18   65.4   0.1    1.6  1  AA_kinase  Amino acid kinase family


Domain annotation for each model (and alignments):
>> AA_kinase  Amino acid kinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.4   0.1   3.1e-22   5.6e-18     115     241 .]      18     176 ..       3     176 .. 0.89

  Alignments for each domain:
  == domain 1  score: 65.4 bits;  conditional E-value: 3.1e-22
                 E......HHHTTTCEEECCHHHHHHHTT-EEEEESEEEEETTTE..........................EEEE-HHHHHHHHHHHCTSSEEEEEESSS CS
   AA_kinase 115 r....degsdgnvesvdaeaieelleagvvpvltgfigldeege..........................lgrgssDtiaallAealgAdkliiltdVd 183
                       ++s+ ++  ++ ++i++l+++g++++++g++g+++ +                            +++++D++++llA++l +d+ iilt Vd
  EFC35822.1  18 EgyrrVVPSPTPIDIIELDTIKTLFNEGHLVICNGGGGIPVVKSrdevggdekamigkkqaqrknhlmgiEAVIDKDRSSSLLAQKLTVDYFIILTKVD 116
                 14455789999************************9977777777777779999988888888888877777*************************** PP

                 SCESSTTTTCCTTCECCEEEHHHCHH..CSSS.TTTHHHHCHHHHHHHHHCTT-EEEEEE CS
   AA_kinase 184 GVydadpkkvpdarllpeisvdeaee..saselatgGmkvkhpaalaaarrggipvvItn 241
                 +Vy +  +k +  ++++ ++v++a++  +++ +  g m +k+++a +++ + g p+ It+
  EFC35822.1 117 HVYLNYSSKKEEKKPITSMDVETARQyiTEGCFEEGTMLPKIESATEFVTKTGKPALITS 176
                 ***************************************************99***9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (206 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       594  (0.0331307); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1313.26
//
Query:       EFC35823.1  [L=296]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.068   13.8   4.9        2.8    8.6   0.5    2.6  2  FOXP-CC      FOXP coiled-coil domain
       0.15   12.2   8.4       0.61   10.2   7.0    2.6  2  zf_ZIC       Zic proteins zinc finger domain
        4.7    7.9  16.1        4.5    7.9   4.0    3.8  3  zf-C2H2      Zinc finger, C2H2 type


Domain annotation for each model (and alignments):
>> FOXP-CC  FOXP coiled-coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.5    0.0021        13      12      32 ..      63      83 ..      59      89 .. 0.91
   2 ?    8.6   0.5   0.00047       2.8      12      39 ..      90     117 ..      84     125 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0021
     FOXP-CC 12 CekvledveeflkhlnseHal 32
                C+  + ++e++lkh+ +eH++
  EFC35823.1 63 CDYSCVKSETLLKHITKEHSI 83
                8999***************97 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00047
     FOXP-CC  12 CekvledveeflkhlnseHalddkstaq 39 
                 C+k+ +++ee++ h+n +H+++ ks+ +
  EFC35823.1  90 CDKHYTTMEEYVDHINFKHQTNTKSAIE 117
                 9**********************99865 PP

>> zf_ZIC  Zic proteins zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.5      0.12   6.9e+02      33      42 ..      72      81 ..      47      83 .. 0.80
   2 ?   10.2   7.0    0.0001      0.61      14      42 ..      78     108 ..      67     109 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.12
                HHHHHHHCTT CS
      zf_ZIC 33 elVtHltveH 42
                 l  H+t eH
  EFC35823.1 72 TLLKHITKEH 81
                5789*****9 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.0001
                 -TT-..SSS-------BSSHHHHHHHHHCTT CS
      zf_ZIC  14 deeq..gspkkpCsktFstmhelVtHltveH 42 
                  +e+  + pk  C+k+++tm e V H+   H
  EFC35823.1  78 TKEHsiKFPKVCCDKHYTTMEEYVDHINFKH 108
                 555533568999***************9988 PP

>> zf-C2H2  Zinc finger, C2H2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.4      0.33     2e+03       2       9 ..      16      23 ..      16      27 .. 0.85
   2 ?    7.9   4.0   0.00075       4.5       3      23 .]      60      81 ..      60      81 .. 0.96
   3 ?    6.4   0.3    0.0022        13       6      23 .]      90     108 ..      90     108 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.33
                EETTTTEE CS
     zf-C2H2  2 kCpdCgks 9 
                +C+ C+ks
  EFC35823.1 16 RCDSCKKS 23
                79****98 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00075
                ETTTTEEESSHHHHHHHHHC.C CS
     zf-C2H2  3 CpdCgksFkrksnLkrHirt.H 23
                C  C++s+  ++ L +Hi + H
  EFC35823.1 60 CCLCDYSCVKSETLLKHITKeH 81
                999***************9988 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0022
                 TTEEESSHHHHHHHHHC.C CS
     zf-C2H2   6 CgksFkrksnLkrHirt.H 23 
                 C+k +++ ++++ Hi+  H
  EFC35823.1  90 CDKHYTTMEEYVDHINFkH 108
                 ***************9777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1084  (0.0604607); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.25s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1887.94
//
Query:       EFC35824.1  [L=582]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-50  171.6   0.1    6.9e-50  169.5   0.1    2.0  1  Copine         Copine
    2.8e-15   56.2   0.1    5.1e-15   55.4   0.1    1.4  1  WH1            WH1 domain
    2.9e-11   43.6   0.0    7.7e-11   42.2   0.0    1.8  1  PBD            P21-Rho-binding domain
     0.0039   17.3   0.0     0.0068   16.5   0.0    1.5  1  vWA-TerF-like  vWA found in TerF C terminus
  ------ inclusion threshold ------
       0.26   10.5   9.4       0.37    9.9   9.4    1.2  1  SOG2           RAM signalling pathway protein
        5.1    6.6  14.2        8.1    5.9  14.2    1.2  1  Pneumo_att_G   Pneumovirinae attachment membrane glycoprotein
        8.8    6.1  10.9         14    5.5  10.9    1.2  1  SPX            SPX domain


Domain annotation for each model (and alignments):
>> Copine  Copine
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.5   0.1   2.7e-53   6.9e-50       1     216 [.     350     572 ..     350     574 .. 0.91

  Alignments for each domain:
  == domain 1  score: 169.5 bits;  conditional E-value: 2.7e-53
      Copine   1 sLHyispeqpneYekallsvgeilqaydsdklipafGFGaklpsdaevsdefvlnfneenkevegiegvleaYrealpnlql......ygPT....... 86 
                 sLHy+s +++n+Y++al +v++il++ydsdk ++a+G+Ga++ ++ +++  f+l+++++++ + g  ++leaY++a+p+l+       + P        
  EFC35824.1 350 SLHYLS-SKKNHYQQALAQVLQILEPYDSDKIYGAYGYGARIDKELKMNPMFNLSLSDKEELCVG--EILEAYEKAVPRLSFgdmgsaTNPKtgkpyrg 445
                 8*****.999***********************************************99999987..9***********97533222222212222233 PP

      Copine  87 .nfapviekvakiaeasakeasqYfvLliitDGvvtdmketidaivaAsklplSiiivGvGdadfekmreldddd.alkssdgriakRdivqfVdfrdl 183
                  +f  vie+v++     +++++ Y +Ll+i DG   dm+ tid+i++A + p+Si+ivG+G + f + r++d+dd  l +s+g  ++RdivqfV f++ 
  EFC35824.1 446 dDFYRVIEHVVERTPPVTQQQQFYNILLLIIDGDAFDMQGTIDSIIEANDKPISIVIVGIGGRSFPSCRKFDADDePLIHSNGTKMTRDIVQFVSFSEC 544
                 37999*********************************************************************999********************** PP

      Copine 184 ksnasakeaalakavLaeiPkqlkaylelrklk 216
                  +      ++la++vLaeiPkq+++y+e++++ 
  EFC35824.1 545 SD-----LTQLASEVLAEIPKQMVTYFESKEII 572
                 99.....999******************99875 PP

>> WH1  WH1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.4   0.1     2e-18   5.1e-15      13     109 ..      30     124 ..      22     126 .. 0.87

  Alignments for each domain:
  == domain 1  score: 55.4 bits;  conditional E-value: 2e-18
                 EEEEEEEEEETTTTCEEEECECEEEEEEEEETTTTEEEEEEEETTT-SEEEEEEE-SS---B-SSSSEEEEESSSSEEEEEESSHHHHHHHHHHHHH CS
         WH1  13 savaqvyladpakketWikakhagavslvkdstqnsyflrlvklqdakvvieqeiyknleynqarqkfhtfederavvGLnFaseeeakkFakkvqe 109
                 sa +++y+a ++ ++ W++a+  g + +   + q +  +rlv+l+ + v +eqe y+++ y++ + +fh fe ++++vGL Fa++ +a++Fak+v +
  EFC35824.1  30 SAPVRLYKA-NNGNQ-WSYANSYGILTVTLVEKQSVVMIRLVDLKSKSVTMEQECYEGFDYQTLSSNFHAFESDDGFVGLLFAERFDADQFAKQVCQ 124
                 678999999.44445.****7766666666667889999******************************************************9965 PP

>> PBD  P21-Rho-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.2   0.0     3e-14   7.7e-11       2      52 ..     259     310 ..     258     314 .. 0.90

  Alignments for each domain:
  == domain 1  score: 42.2 bits;  conditional E-value: 3e-14
                 B---.EE.EEEEEEEEEETTTTEEES--CCHCCCHHHT.TTSXXXBEXXXXXX CS
         PBD   2 IStP.tn.fkHtvHVGwdgdsgnftglPpewkkllkssgItedelkenpkavl 52 
                 IS P  + fkH++H+G+d++ g ft++Pp+ k +++++gI+e elk+  +a +
  EFC35824.1 259 ISGPkVDkFKHVSHIGFDPKLG-FTEIPPQLKTIFEKAGISEAELKDKKTAKF 310
                 88888555**************.6***********************999876 PP

>> vWA-TerF-like  vWA found in TerF C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   2.7e-06    0.0068      84     154 ..     446     518 ..     347     559 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 2.7e-06
  vWA-TerF-like  84 neeapvleevlekvrk..epaelptlvlFitDGgvkkkkeiekalreaskepiFwqFvglgkseygvLeklDd 154
                     +  +v+e+v+e+     ++++   ++l i DG++ + + + + ++ea ++pi    vg+g +++   +k+D 
     EFC35824.1 446 DDFYRVIEHVVERTPPvtQQQQFYNILLLIIDGDAFDMQGTIDSIIEANDKPISIVIVGIGGRSFPSCRKFDA 518
                    566789999998875433666677888999****************************************995 PP

>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   9.4   0.00014      0.37     244     345 ..     134     231 ..      80     273 .. 0.59

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00014
        SOG2 244 srrssssgnsaspaangaqsetsersasssg.vqssasstPlgegstsppgalsrqslsttgs..tstltsssksrsssrsntnasastprslattpap 339
                 ++ s++s +s++p+ n+++ +++ +s+s +g  +s+a++tP+++++++p  +++ ++++++++  ts   sss ++ s++s    s++ p+++   p+ 
  EFC35824.1 134 INGSTPSLPSTKPSVNMRSDSSDSSSSSPTGtGSSTAPPTPVKKTNPPP--STPPPVANKPTAvnTSIAASSSVHTTSTTS----SHKEPEKKH-IPSN 225
                 4455566666666666665555555555556666677777777766666..222222222222002222222222222222....222222222.2222 PP

        SOG2 340 pasaes 345
                 ++s+ s
  EFC35824.1 226 SSSGGS 231
                 222222 PP

>> Pneumo_att_G  Pneumovirinae attachment membrane glycoprotein G
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  14.2    0.0032       8.1     174     246 ..     157     233 ..     144     266 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0032
  Pneumo_att_G 174 tskttskpaev.stPaypsqra..sksdpasqgeqtataklllastesvltedtat.skssepqleprpsqrGksts 246
                   +s+ ++ ++ + + P+ p +++  + s p++ ++++++ ++ +a+  sv t  t+  +k +e++  p+ s+ G s+s
    EFC35824.1 157 SSSSSPTGTGSsTAPPTPVKKTnpPPSTPPPVANKPTAVNTSIAASSSVHTTSTTSsHKEPEKKHIPSNSSSGGSSS 233
                   455566666665889888876633689****************9999998877665155666666666665665554 PP

>> SPX  SPX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5  10.9    0.0053        14      62     163 ..     144     248 ..     120     283 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0053
         SPX  62 e......rtepstsaaadesgnsaadasssepkdeaeslprrsplsrssrssssygglvssppsansssssddssesnpadssssssssesessssssp 154
                 +      r+++s+s++++++g+ +++a ++++k++  ++p+++p    ++++   +++ +s++ + +s+ s++++++     ++  s+s+s++ssss  
  EFC35824.1 144 TkpsvnmRSDSSDSSSSSPTGTGSSTAPPTPVKKT--NPPPSTPPPVANKPTAVNTSIAASSSVHTTSTTSSHKEPEK----KHIPSNSSSGGSSSSGG 236
                 02344566666777777777777777777776666..89999999888888888888888888888888888888888....88888999999999999 PP

         SPX 155 sllrrlfs...e 163
                  l++++f+   +
  EFC35824.1 237 GLFSKIFGtknK 248
                 9*****993220 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (582 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       744  (0.041497); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.49u 0.22s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 4241.17
//
Query:       EFC35825.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.6e-05   22.5   7.7    9.6e-05   22.5   7.7    1.5  2  Rootletin       Ciliary rootlet component, centrosome cohesio
    0.00031   20.8   3.5        0.2   11.7   0.9    3.1  3  COG2            COG (conserved oligomeric Golgi) complex comp
  ------ inclusion threshold ------
      0.019   15.0   1.5      0.019   15.0   1.5    2.8  3  TPR_MLP1_2      TPR/MLP1/MLP2-like protein
      0.062   13.2  10.9      0.068   13.1  10.0    1.6  1  CortBP2         Cortactin-binding protein-2
      0.097   12.3   0.3       0.12   12.0   0.3    1.3  1  Carbam_trans_N  Carbamoyltransferase N-terminus
        0.6   10.0   4.1        1.8    8.5   0.1    3.5  4  PKcGMP_CC       Coiled-coil N-terminus of cGMP-dependent prot
        2.4    8.6  14.0    2.2e+02    2.2  12.4    2.9  2  DUF4200         Domain of unknown function (DUF4200)
        2.6    8.4  11.5        7.6    6.9   1.3    4.1  3  Lzipper-MIP1    Leucine-zipper of ternary complex factor MIP1
        8.1    6.6  12.3        1.3    9.2   4.6    2.7  3  Fib_alpha       Fibrinogen alpha/beta chain family


Domain annotation for each model (and alignments):
>> Rootletin  Ciliary rootlet component, centrosome cohesion
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0         3   6.1e+03     106     119 ..      21      34 ..       5      50 .. 0.60
   2 !   22.5   7.7   4.8e-08   9.6e-05      19     115 ..      95     214 ..      81     230 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3
   Rootletin 106 aLtedlqkltkdwe 119
                 +L ++++ lt++++
  EFC35825.1  21 HLYDEINDLTSELS 34 
                 34444444444433 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 4.8e-08
   Rootletin  19 skLqaKvlqYkkrcseleqrlle......ktselektkltlll.................ssareleeeesadleealakLeeErqrseklaqvnslLr 94 
                 ++L +K+ +Ykk  ++ e  l++      k+ +  ++k+++l+                 s+++ ++++ +++++++  +L  E  ++e+l + n++Lr
  EFC35825.1  95 NSLERKLVNYKKLGKDSEVSLAQckklytKSKDESNKKIHDLTtslhgrldeiqllkkglSNEKDITNSLKTEIDRLKYRLSIEVTQTESLRKSNDILR 193
                 6899**************88888766665555555555544447888888888888888777799********************************** PP

   Rootletin  95 eqleearqaneaLtedlqklt 115
                 +ql +++  ++ L++++ k++
  EFC35825.1 194 QQLLKTQDYSNFLHKEILKIE 214
                 ****************99975 PP

>> COG2  COG (conserved oligomeric Golgi) complex component, COG2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.0    0.0085        17      81     127 ..      22      71 ..      15      77 .. 0.88
   2 ?    2.7   0.1     0.064   1.3e+02      32      48 ..      87     103 ..      68     105 .. 0.80
   3 !   11.7   0.9    0.0001       0.2      59     120 ..     135     196 ..     129     209 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0085
        COG2  81 arkkvesvreklsereeeveskleeakeleekr...ellklllkldevve 127
                 + +++++++++ls + + ++s l+e +   +++   e+lk++ +l+e ++
  EFC35825.1  22 LYDEINDLTSELSTKLNLLNSVLSEDTPYHRNQvpfEFLKSMHNLSESIS 71 
                 5689*****************************99999999988888766 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.064
        COG2  32 rrdLeaylkllekelle 48 
                  r+Le+y+++le++l++
  EFC35825.1  87 FRELEQYANSLERKLVN 103
                 589***********985 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 0.0001
        COG2  59 slSghLvglqeeleevesplaaarkkvesvreklsereeeveskleeakeleekrellklll 120
                 +l ++L+g  +e++ +++ l++ ++  +s++ ++++ +++++ ++ + ++l++ + +l+  l
  EFC35825.1 135 DLTTSLHGRLDEIQLLKKGLSNEKDITNSLKTEIDRLKYRLSIEVTQTESLRKSNDILRQQL 196
                 5889*************************************************997776433 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       6.6   1.3e+04       6      11 ..      29      34 ..      22      45 .. 0.45
   2 ?   15.0   1.5   9.8e-06     0.019      66     117 ..      87     138 ..      81     147 .. 0.89
   3 ?    4.9   2.0     0.012        25      58     117 ..     146     187 ..     141     210 .. 0.56

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 6.6
  TPR_MLP1_2  6 leeeik 11
                l++e++
  EFC35825.1 29 LTSELS 34
                222222 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 9.8e-06
  TPR_MLP1_2  66 lnelkaeiaelkaeaesakaeleeseesweeqkeelekelselekriedlne 117
                 + el++ +++l+ ++ + k+  + se s+++ k+ + k ++e++k+i dl++
  EFC35825.1  87 FRELEQYANSLERKLVNYKKLGKDSEVSLAQCKKLYTKSKDESNKKIHDLTT 138
                 67999*********************************************85 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.012
  TPR_MLP1_2  58 elqalreelnelkaeiaelkaeaesakaeleeseesweeqkeelekelselekriedlne 117
                 e+q l++ l++ k+  ++lk+e +++k  l+ +  + e                   l +
  EFC35825.1 146 EIQLLKKGLSNEKDITNSLKTEIDRLKYRLSIEVTQTE------------------SLRK 187
                 56666666666666666666666666666664433222..................2222 PP

>> CortBP2  Cortactin-binding protein-2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1  10.0   3.4e-05     0.068      48     173 ..      63     198 ..      43     212 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.4e-05
     CortBP2  48 kvnlsdplqALqRDselaksketsesevkklye..........kqlaeLekliekqreaqermleqLaaaekrhrkvleeLeeekrkheedtaqgddvt 136
                  +nls+ ++ L RD    +++e +  e+++ ++          k  +  e  ++++++ + + +++  +  +  ++ l+   +e +  ++ ++++ d+t
  EFC35825.1  63 MHNLSESISFLTRDTIFERQSEIKFRELEQYANslerklvnykKLGKDSEVSLAQCKKLYTKSKDESNKKIHDLTTSLHGRLDEIQLLKKGLSNEKDIT 161
                 56789999999999955555555554555444445533333322222223334566666666666666666666666666677788888889999**** PP

     CortBP2 137 ylLekererLkqeleqekaqkkklekelkklleklee 173
                 + L++e +rLk  l  e +q ++l+k ++ l ++l +
  EFC35825.1 162 NSLKTEIDRLKYRLSIEVTQTESLRKSNDILRQQLLK 198
                 ********************99999998888777654 PP

>> Carbam_trans_N  Carbamoyltransferase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.3   5.9e-05      0.12     198     287 ..      93     179 ..      25     193 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 5.9e-05
  Carbam_trans_N 198 kknsdegKlmalaayGkpkeriveelyellkkagyrinl.ennieiskkkvhdffeasalrlkearekdedlaAsiqvflErlvvevlniv 287
                     + ns e Kl  + ++Gk  e  +++  +l+ k++   n+ ++++      +h ++++++l +k   ++ +d++ s+++ ++rl  ++   v
      EFC35825.1  93 YANSLERKLVNYKKLGKDSEVSLAQCKKLYTKSKDESNKkIHDL---TTSLHGRLDEIQLLKKGLSNE-KDITNSLKTEIDRLKYRLSIEV 179
                     778889*************************9876777534555...5556799****9887776666.9******999999876664444 PP

>> PKcGMP_CC  Coiled-coil N-terminus of cGMP-dependent protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0         1     2e+03      22      31 ..      24      33 ..      23      35 .. 0.87
   2 ?    0.2   0.2      0.35     7e+02       7      15 ..      84      92 ..      81     100 .. 0.85
   3 ?    8.5   0.1   0.00089       1.8       5      29 ..     125     152 ..     123     155 .. 0.86
   4 ?   -3.6   0.0       5.5   1.1e+04      23      31 ..     167     175 ..     166     175 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1
   PKcGMP_CC 22 eEIqELrskL 31
                +EI++L s L
  EFC35825.1 24 DEINDLTSEL 33
                89***99877 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.35
   PKcGMP_CC  7 DERIRELEk 15
                +++ RELE+
  EFC35825.1 84 EIKFRELEQ 92
                7899***96 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00089
   PKcGMP_CC   5 lKDE...RIRELEkrlaekdeEIqELrs 29 
                 +KDE   +I +L   l+ + +EIq L+ 
  EFC35825.1 125 SKDEsnkKIHDLTTSLHGRLDEIQLLKK 152
                 67776669****************9997 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 5.5
   PKcGMP_CC  23 EIqELrskL 31 
                 EI  L+ +L
  EFC35825.1 167 EIDRLKYRL 175
                 899999877 PP

>> DUF4200  Domain of unknown function (DUF4200)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       2.2   4.4e+03      71      91 ..      15      35 ..       9      42 .. 0.70
   2 ?    2.2  12.4      0.11   2.2e+02      33     115 ..      87     208 ..      74     211 .. 0.65

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.2
     DUF4200 71 erklkkekeaeikklkaeiet 91
                 + l+ +   ei++l++e++t
  EFC35825.1 15 DESLRMHLYDEINDLTSELST 35
                556666677788888877765 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.11
     DUF4200  33 eeelekkeqeleedllkfdkflkendakraralkkaeeerklkkekeaeik.klkaeietlk..................................... 93 
                  +ele+  + le++l++++k  k+ +   a+  k + + +++  +k  ++   l+  +++++                                     
  EFC35825.1  87 FRELEQYANSLERKLVNYKKLGKDSEVSLAQCKKLYTKSKDESNKKIHDLTtSLHGRLDEIQllkkglsnekditnslkteidrlkyrlsievtqtesl 185
                 467888888888888888888888888888888887666665555555543145555555555556666666666666655555555555555556555 PP

     DUF4200  94 .seiekleekleeykkYeefLek 115
                  + ++ l ++l + + Y +fL+k
  EFC35825.1 186 rKSNDILRQQLLKTQDYSNFLHK 208
                 57777777777777778888765 PP

>> Lzipper-MIP1  Leucine-zipper of ternary complex factor MIP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   1.1     0.027        54      67      82 ..      87     102 ..      14     104 .. 0.72
   2 ?    2.5   0.1     0.088   1.8e+02      11      30 ..     145     164 ..     128     165 .. 0.80
   3 ?    6.9   1.3    0.0038       7.6       6      34 ..     161     189 ..     156     233 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.027
  Lzipper-MIP1  67 vvkLEqkllsLyrklf 82 
                     +LEq+ +sL+rkl 
    EFC35825.1  87 FRELEQYANSLERKLV 102
                   45799******99986 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.088
  Lzipper-MIP1  11 qeveqLqerLqeeeklrraL 30 
                    e++ L++ L++e+++  +L
    EFC35825.1 145 DEIQLLKKGLSNEKDITNSL 164
                   58999999999999998877 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0038
  Lzipper-MIP1   6 rssLeqeveqLqerLqeeeklrraLekal 34 
                     sL++e+ +L+ rL+ e +  ++L+k  
    EFC35825.1 161 TNSLKTEIDRLKYRLSIEVTQTESLRKSN 189
                   579****************9999999875 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.7     0.008        16      45     133 ..      24     119 ..      16     122 .. 0.75
   2 ?    9.2   4.6   0.00063       1.3      44     128 ..      87     171 ..      81     175 .. 0.81
   3 ?    0.6   1.8      0.29   5.7e+02      84     118 ..     162     196 ..     156     243 .. 0.60

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.008
                 CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHCCCHHH.HHHHCCHHHH..HHHHHHHHHHHHHH...HHHHHHHHHHHHHTT CS
   Fib_alpha  45 eeisnstkeaeelvkeikdslrekqkskkdn.dnvikksskeleeeilrlk.etidaqesni..rvLqnvlesneqki...qkLeqdidqkerkCk 133
                 +ei++ t+e ++  + ++++l e+   ++++    + ks ++l e i+ l  +ti +  s+i  r+L +  +s+e+k+   +kL +d++   ++Ck
  EFC35825.1  24 DEINDLTSELSTKLNLLNSVLSEDTPYHRNQvPFEFLKSMHNLSESISFLTrDTIFERQSEIkfRELEQYANSLERKLvnyKKLGKDSEVSLAQCK 119
                 578888889999999999999999888886666777788888998998875257877776662267999999998887444678888888888887 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00063
                 CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  44 leeisnstkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesneqkiqkLeqdidqk 128
                 ++e+++  ++ e+  ++ k+  ++ + s ++ +++++ks++e +++i +l  ++     +i+ L++ l++ +   + L+++id +
  EFC35825.1  87 FRELEQYANSLERKLVNYKKLGKDSEVSLAQCKKLYTKSKDESNKKIHDLTTSLHGRLDEIQLLKKGLSNEKDITNSLKTEIDRL 171
                 5566777777777777878887888888887799999999999999999999999999999999999998888888899999876 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.29
                 HHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  84 keleeeilrlketidaqesnirvLqnvlesneqki 118
                 ++l++ei rlk +++ ++++ + L++  + ++q++
  EFC35825.1 162 NSLKTEIDRLKYRLSIEVTQTESLRKSNDILRQQL 196
                 34444444444444444444444444443333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1365  (0.0761336); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 1574.74
//
Query:       EFC35826.1  [L=272]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.066   12.5   1.0      0.088   12.1   1.0    1.1  1  NicO      High-affinity nickel-transport protein


Domain annotation for each model (and alignments):
>> NicO  High-affinity nickel-transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.0   4.9e-06     0.088      68     152 ..     116     208 ..      94     219 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.9e-06
        NicO  68 ltslsetgaaigteiasFllvilllnllllrklrklfrklerlgrapaaeleaalakr.........gllsrilgklfrlitkswhmypvgflf 152
                 +++ +e++ +++ ++ s+l+++ l+ l+ +r +r+l++ +++ +  +  ++ +++a++          ++ ++ ++ +  +++++h + +++ +
  EFC35826.1 116 TNNQTEKDMQMAFKVLSYLYMAILILLFTFRYVRELIAISRK-KPLSIWSTHYLHAGHsvslylakaQHIPKNAHPGHDQNQNHYHDAFDHHAH 208
                 455677788889999**********************99999.888888999999999999999999667777778888888888888887654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       729  (0.0406604); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.51
# Mc/sec: 1611.68
//
Query:       EFC35827.1  [L=572]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.8e-18   64.5   0.4    1.6e-17   63.6   0.1    1.7  2  Response_reg  Response regulator receiver domain
    3.5e-07   30.2   0.0    3.1e-05   23.9   0.1    2.7  2  HisKA         His Kinase A (phospho-acceptor) domain
  ------ inclusion threshold ------
       0.12   12.2   1.2        3.9    7.4   0.0    3.0  3  partial_CstF  Partial cleavage stimulation factor domain
        0.2   11.4   5.7       0.24   11.2   0.1    2.2  2  DUF4588       Domain of unknown function (DUF4588)


Domain annotation for each model (and alignments):
>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       2.4   1.1e+04       2      15 ..      90     103 ..      90     117 .. 0.76
   2 !   63.6   0.1   3.7e-21   1.6e-17       1     111 [.     449     563 ..     449     564 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.4
                   EEESSSHHHHHHHH CS
  Response_reg   2 livdDdplvrellr 15 
                   l+vdD  ++r+++ 
    EFC35827.1  90 LVVDDIIKNRRNID 103
                   79999999999885 PP

  == domain 2  score: 63.6 bits;  conditional E-value: 3.7e-21
                   EEEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHHHHHHESEEEEESSCSSSEHHHHHHHHHHCT.....TTSEEEEEESSTSHHHHHHHHHC CS
  Response_reg   1 vlivdDdplvrellrqlleeegyeevaeaedgkealellkeekvdlillDinmpgmdGlellkeireed.....pelpviiltahseeedavealka 92 
                   +li dD+ ++r++++++++  g++ev+ a++g e++e++k++++ +illD+ mp m G + +k+ire +     + +pvi++ta+   e +    ++
    EFC35827.1 449 ILITDDNLINRKVMEKMVRLLGFTEVDCASNGLECFEMYKQKQYSIILLDLLMPVMCGKQSVKHIREFEesegrKRTPVIAITANIW-ESVDTLSQL 544
                   89****************************************************************9997777777*******9996.8899999** PP

                   TESEEEESSG-HHHHHHHH CS
  Response_reg  93 gaddflsKpfdpeeLlkal 111
                   g d ++ Kp+ +e+L++ +
    EFC35827.1 545 GFDSVIYKPILIEKLREEV 563
                   ***************9987 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.1   6.9e-09   3.1e-05       2      31 ..     286     316 ..     285     335 .. 0.79
   2 ?    3.3   0.0     0.018        83      16      66 ..     341     404 ..     339     405 .. 0.69

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 6.9e-09
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHC... CS
       HisKA   2 lgrflagvaHELrtPLsailgnaeaLkre.g 31 
                 ++ ++a+++HE r+PL++i+g++ +L+ + +
  EFC35827.1 286 KTHMIANISHEARNPLHGIIGASTILRHDmE 316
                 6789**********************66441 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.018
                 HHHHHHHHHHHHHC...............T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH CS
       HisKA  16 PLsailgnaeaLkre.............gklteelkeyletiesearrldhlvedlLdlsriea 66 
                 P++a  g++++  ++               + +   e++++i ++a+ l+h+ ++ L+++++e 
  EFC35827.1 341 PMNAKNGFLHVSNDDghyssdcesscgdSTAEQPYLELVNDIYNNANLLLHIFSTSLQMTSLEM 404
                 55666666666655556666666666432222333459********************999985 PP

>> partial_CstF  Partial cleavage stimulation factor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.1     0.044     2e+02       8      27 ..      45      64 ..      40      67 .. 0.83
   2 ?   -2.3   0.0      0.86   3.8e+03      17      25 ..      91      99 ..      82     102 .. 0.75
   3 ?    7.4   0.0   0.00086       3.9      12      34 ..     373     395 ..     367     402 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.044
  partial_CstF  8 sgvepaeeaLVdeViknkdi 27
                  + +++ +e+L+ eV +n ++
    EFC35827.1 45 DSISNMKENLITEVKNNDEL 64
                  679999********999765 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.86
  partial_CstF 17 LVdeViknk 25
                   Vd +ikn+
    EFC35827.1 91 VVDDIIKNR 99
                  5899**996 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.00086
  partial_CstF  12 paeeaLVdeViknkdiLqnilks 34 
                   ++  +LV+ + +n ++L +i + 
    EFC35827.1 373 QPYLELVNDIYNNANLLLHIFST 395
                   55669**************9854 PP

>> DUF4588  Domain of unknown function (DUF4588)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   1.7     0.038   1.7e+02     141     195 ..     135     189 ..      91     233 .. 0.59
   2 ?   11.2   0.1   5.3e-05      0.24     164     248 ..     256     339 ..     242     341 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.038
     DUF4588 141 revekdksssatelsssveidLqpfreaialnslsgamskislavelrsptsfrp 195
                  +  ++++ +++e  +++    q++r+++ +ns + +  k+++  +++ +  +++
  EFC35827.1 135 IPILPKTKDQEKEKMQKNKLTFQNSRNSLFQNSNKTTYTKVEMNKQSNDKRGQTK 189
                 3333443446677777777779999999999999999999665555544444433 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 5.3e-05
     DUF4588 164 pfreaialnslsgamskislavelrsptsfrpssvsakssrrrlailksledlsefesddlarhldsrkrsssqkddvltdsPsr 248
                 ++r a+++++l  ++s + +a+  ++  s +++ + a+ s+   + l+ + + s++  +d+ ++  s kr +   ++++ +sPs+
  EFC35827.1 256 AYR-ALSQQNLFFMTSWFRFAYMQEKYLSNEKTHMIANISHEARNPLHGIIGASTILRHDMEKNSHSDKRKKRGRKNSILQSPSH 339
                 443.788888888899999999999999999999999999999999****************99999999998999********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (572 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1190  (0.0663729); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 3359.00
//
Query:       EFC35828.1  [L=152]
Description: polyubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.4e-63  208.2   5.9    6.7e-31  105.9   0.5    2.0  2  ubiquitin    Ubiquitin family
    2.9e-30  103.9   7.5    8.2e-15   54.4   1.0    2.0  2  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
    5.5e-09   36.4   3.2     0.0014   19.0   0.3    3.1  2  Ubiquitin_2  Ubiquitin-like domain
    1.3e-08   34.6   0.2     0.0026   17.7   0.0    2.2  2  TBK1_ULD     TANK binding kinase 1 ubiquitin-like domain
    1.4e-08   34.8   0.4      0.001   19.2   0.0    2.8  2  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
    5.8e-07   29.8   1.6      0.025   14.9   0.2    2.1  2  Ubiquitin_5  Ubiquitin-like domain
    1.2e-06   29.0   0.1      0.015   15.9   0.0    2.1  2  DUF2407      DUF2407 ubiquitin-like domain
      9e-05   22.4   6.5        2.6    8.1   0.1    4.0  4  Ubiquitin_4  Ubiquitin-like domain
  ------ inclusion threshold ------
      0.043   13.7   0.3        3.3    7.6   0.1    2.2  2  Coagulin     Coagulin
       0.05   13.8   0.6       0.84    9.8   0.1    2.3  2  DUF3861      Domain of Unknown Function with PDB structure (D
      0.072   13.5   1.0       0.84   10.0   0.2    2.5  3  bPH_3        Bacterial PH domain
       0.11   12.2   0.0          7    6.4   0.0    2.3  2  Raf1_HTH     Rubisco accumulation factor 1 helix turn helix d
       0.14   12.3   1.4         17    5.6   0.2    2.2  2  ProRS-C_2    Prolyl-tRNA synthetase, C-terminal
       0.22   11.7   1.5        2.2    8.5   0.2    2.6  3  PI3K_rbd     PI3-kinase family, ras-binding domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  105.5   0.6   6.6e-34   8.4e-31       1      72 []       3      74 ..       3      74 .. 0.99
   2 !  105.9   0.5   5.2e-34   6.7e-31       1      72 []      79     150 ..      79     150 .. 0.99

  Alignments for each domain:
  == domain 1  score: 105.5 bits;  conditional E-value: 6.6e-34
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                ++vktl+g++itleve++d++e++K k+++kegi ++qqrLi++Gk+Led rt+ +y+iq++stlhlvlrlr
  EFC35828.1  3 LFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQLEDGRTINDYNIQKDSTLHLVLRLR 74
                79*******************************************************************986 PP

  == domain 2  score: 105.9 bits;  conditional E-value: 5.2e-34
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 ++vktl+gk+it+e+e++dtve+ K+ki +kegip +qqrLiy+Gk+Led rt+++y++q++st+hlvlrlr
  EFC35828.1  79 LFVKTLTGKTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQLEDGRTIGDYNLQKDSTVHLVLRLR 150
                 79*******************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.7   0.8   1.1e-17   1.4e-14       1      72 []       1      71 [.       1      71 [. 0.98
   2 !   54.4   1.0   6.4e-18   8.2e-15       1      72 []      77     147 ..      77     147 .. 0.98

  Alignments for each domain:
  == domain 1  score: 53.7 bits;  conditional E-value: 1.1e-17
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                +++++k+ +g +++++V+++  +++++++ ++k+gi++ +++rLiF G++L++  t++d+ i++++t+++v+
  EFC35828.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISP-DQQRLIFAGKQLEDGRTINDYNIQKDSTLHLVL 71
                79************************************.******************************986 PP

  == domain 2  score: 54.4 bits;  conditional E-value: 6.4e-18
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 +++++k+ +gk+++i+ +++ tv++++++  +k+gip  +++rLi+ G++L++  t++d+ +++++t+++v+
  EFC35828.1  77 MQLFVKTLTGKTITIEMESNDTVENMKQKIFDKEGIPS-DQQRLIYAGKQLEDGRTIGDYNLQKDSTVHLVL 147
                 79************************************.******************************996 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.2   8.2e-06      0.01      18      79 ..      15      68 ..       3      71 .. 0.79
   2 !   19.0   0.3   1.1e-06    0.0014      14      79 ..      87     144 ..      77     146 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 8.2e-06
                 EEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2 18 rrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79
                   ++++++ie++K+k++   G+sp+++rL +          k  +d ++ ++Y+++  +++h
   EFC35828.1 15 LEVESNDSIENVKRKVQDKEGISPDQQRLIFA--------GKQLEDGRTINDYNIQKDSTLH 68
                 5678899**********************997........4445677777777777777776 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 1.1e-06
                  SEEEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2  14 vsserrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79 
                  +  ++ +++++t+e++K+k+    G++ +++rL +          k  +d ++ g+Y+++  +++h
   EFC35828.1  87 KTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYA--------GKQLEDGRTIGDYNLQKDSTVH 144
                  567788999************************998........4556788888888888888888 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   1.1e-05     0.015      19      55 ..      17      51 ..       9      72 .. 0.83
   2 !   17.7   0.0     2e-06    0.0026      15      52 ..      89     126 ..      80     142 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.1e-05
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrllle 55
                +++++ ++++  +v+++  i++++Q l+f g++l  e
  EFC35828.1 17 VESNDSIENVKRKVQDKEGISPDQQRLIFAGKQL--E 51
                6789999*************************87..3 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 2e-06
    TBK1_ULD  15 hkiYihpyntvaifqeevakqTkiaaekQellfeghrl 52 
                 ++i +++++tv+++ ++++++  i++++Q l++ g++l
  EFC35828.1  89 ITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQL 126
                 66778999***************************997 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   7.5e-05     0.096      18      87 ..      15      71 ..       2      75 .. 0.72
   2 !   19.2   0.0   7.8e-07     0.001      11      87 ..      85     147 ..      77     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.5e-05
                 EEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2 18 vkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87
                 ++ +++++++++k+kv      dke    s+++ +li aGk Le+ +t+++++++        +++H+v+
   EFC35828.1 15 LEVESNDSIENVKRKVQ-----DKEG--ISPDQQRLIFAGKQLEDGRTINDYNIQKD------STLHLVL 71
                 56677777777777774.....4444..567778****************9965433......3466665 PP

  == domain 2  score: 19.2 bits;  conditional E-value: 7.8e-07
                  TS-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  11 dGsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                   G+ +  +++++++tv+++k+k++++     e  p++    +li+aGk Le+ +t+++++l+         ++H+v+
   EFC35828.1  85 TGK-TITIEMESNDTVENMKQKIFDK-----EGIPSDQ--QRLIYAGKQLEDGRTIGDYNLQKDS------TVHLVL 147
                  577.77789999************74.....4455544..48****************9655433......466665 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.2     2e-05     0.025      34      93 ..      13      73 ..       5      78 .. 0.83
   2 !   14.3   0.1     3e-05     0.039      34      93 ..      89     149 ..      80     151 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2e-05
  Ubiquitin_5 34 klletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93
                  +le++ + + +++ +k+ ++ g+  ++ +li  gk+le ++t+++ +++++s + +vL+l
   EFC35828.1 13 ITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQLEDGRTINDYNIQKDSTLhLVLRL 73
                 5677777778889999999999***************************999875467765 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 3e-05
  Ubiquitin_5  34 klletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                   ++e++ + t++++ +ki ++ g+  ++ +li+ gk+le ++t+ + +++++s v +vL+l
   EFC35828.1  89 ITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQLEDGRTIGDYNLQKDSTVhLVLRL 149
                  5667777778999************************************999998567765 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.1   0.00024       0.3      15      63 ..      14      58 ..       7      86 .. 0.82
   2 !   15.9   0.0   1.2e-05     0.015      16      62 ..      89     133 ..      67     145 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00024
     DUF2407 15 eLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslas 63
                +L+++  ++ +++++k+ + ++    ++  + rLI+aG+ Led  ++++
  EFC35828.1 14 TLEVE--SNDSIENVKRKVQDKE--GISPDQQRLIFAGKQLEDGRTIND 58
                56666..5667888999999887..88999999**********998875 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 1.2e-05
     DUF2407  16 LdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttsla 62 
                 ++i+  ++ tv+++kq i ++    + s + rLIyaG+ Led  ++ 
  EFC35828.1  89 ITIEMESNDTVENMKQKIFDKE--GIPSDQQRLIYAGKQLEDGRTIG 133
                 678888899**********997..88888889**********98875 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.2    0.0047       6.1       1      33 [.       1      33 [.       1      42 [. 0.91
   2 !    6.5   0.1    0.0066       8.5      58      86 ..      43      70 ..      39      73 .. 0.84
   3 !    8.1   0.1     0.002       2.6       1      30 [.      77     106 ..      77     118 .. 0.91
   4 ?    2.7   0.0      0.11   1.4e+02      58      86 ..     119     146 ..     115     149 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0047
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaierk 33
                 +++ vk l g+++ ++v++n +++++k+ ++ k
   EFC35828.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDK 33
                 78999************************9976 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0066
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L+f g++L+ d  ++++y i+++s+l+ v
   EFC35828.1 43 LIFAGKQLE-DGRTINDYNIQKDSTLHLV 70
                 889999986.6789************976 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.002
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkai 30 
                  +++ vk l g+++ +++++n tv+++k+ i
   EFC35828.1  77 MQLFVKTLTGKTITIEMESNDTVENMKQKI 106
                  78999**********************988 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.11
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L++ g++L+ d  ++ +y ++++s+++ v
   EFC35828.1 119 LIYAGKQLE-DGRTIGDYNLQKDSTVHLV 146
                  889999986.6779*********999876 PP

>> Coagulin  Coagulin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.1    0.0026       3.3      12      44 ..       7      39 ..       5      64 .. 0.86
   2 ?    4.5   0.0     0.023        29      12      43 ..      83     114 ..      80     143 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0026
    Coagulin 12 tllgrkvivsteikdkiekaveavadkdevsgr 44
                tl gr+  +  e +d ie+  + v dk+++s  
  EFC35828.1  7 TLTGRTITLEVESNDSIENVKRKVQDKEGISPD 39
                789***************************964 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.023
    Coagulin  12 tllgrkvivsteikdkiekaveavadkdevsg 43 
                 tl g++  +  e +d +e+  + + dk+++  
  EFC35828.1  83 TLTGKTITIEMESNDTVENMKQKIFDKEGIPS 114
                 788999**********************9954 PP

>> DUF3861  Domain of Unknown Function with PDB structure (DUF3861)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   0.00066      0.84      19      60 ..       9      50 ..       5      84 .. 0.90
   2 ?    2.2   0.1      0.16     2e+02      19      59 ..      85     125 ..      78     128 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00066
     DUF3861 19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglkL 60
                + +++++e+e+ d i ++ +++++ke++++d+++ +  g +L
  EFC35828.1  9 TGRTITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQL 50
                5579**************************999877777665 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.16
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d + ++ +++ +ke++ +d+++ +  g +
  EFC35828.1  85 TGKTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQ 125
                 557999********999999999999999998877666655 PP

>> bPH_3  Bacterial PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       1.9   2.5e+03      71      91 ..       7      28 ..       3      32 .. 0.58
   2 ?   10.0   0.2   0.00065      0.84      29      93 ..      40     106 ..      36     108 .. 0.90
   3 ?    0.5   0.0      0.62   7.9e+02      29      53 ..     116     140 ..     114     149 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.9
       bPH_3 71 t.sgktitidnidksevrkive 91
                t  g tit++  ++++++++ +
  EFC35828.1  7 TlTGRTITLEVESNDSIENVKR 28
                4456666666666666666555 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00065
       bPH_3  29 nkRiifldpkmfggkdfeeipYksIksvdlkkgl.lgakitlet.sgktitidnidksevrkiveai 93 
                 ++R+if  ++   g++++++  ++ +  +l  +l  g ++ ++t  gktiti++ ++++v+++ + i
  EFC35828.1  40 QQRLIFAGKQLEDGRTINDYNIQKDSTLHLVLRLrGGMQLFVKTlTGKTITIEMESNDTVENMKQKI 106
                 58********9999999**99999999999999977778999999********99*****9997765 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.62
       bPH_3  29 nkRiifldpkmfggkdfeeipYksI 53 
                 ++R+i+  ++   g+++ ++ +++ 
  EFC35828.1 116 QQRLIYAGKQLEDGRTIGDYNLQKD 140
                 58********999999999988875 PP

>> Raf1_HTH  Rubisco accumulation factor 1 helix turn helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.05        64      35      55 ..      29      49 ..      26      52 .. 0.86
   2 ?    6.4   0.0    0.0054         7      33      55 ..     103     125 ..     101     128 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.05
    Raf1_HTH 35 eIfEaTGiepvqQnqliVaaq 55
                ++ ++ Gi+p qQ ++  + q
  EFC35828.1 29 KVQDKEGISPDQQRLIFAGKQ 49
                678999********9998877 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0054
    Raf1_HTH  33 pqeIfEaTGiepvqQnqliVaaq 55 
                  q+If++ Gi   qQ ++  + q
  EFC35828.1 103 KQKIFDKEGIPSDQQRLIYAGKQ 125
                 599************99988877 PP

>> ProRS-C_2  Prolyl-tRNA synthetase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.2     0.014        17       6      26 ..      16      36 ..      12      37 .. 0.85
   2 ?    5.6   0.1     0.014        18       6      26 ..      92     112 ..      88     117 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.014
                S--....HHHHHHHCTTT-SE CS
   ProRS-C_2  6 aenvnlllenikeklsekkGv 26
                ++++n   en+k k+++k G+
  EFC35828.1 16 EVESNDSIENVKRKVQDKEGI 36
                5678999***********998 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.014
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n  +en+k+k+ +k G+
  EFC35828.1  92 EMESNDTVENMKQKIFDKEGI 112
                 567899************997 PP

>> PI3K_rbd  PI3-kinase family, ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.24   3.1e+02      28      50 ..      10      32 ..       2      43 .. 0.80
   2 ?    8.5   0.2    0.0017       2.2      27      52 ..      85     112 ..      76     138 .. 0.81
   3 ?   -2.5   0.0       4.4   5.6e+03      92     103 ..     137     148 ..     134     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.24
                SEEEEEEEETTS-HHHHHHHHHH CS
    PI3K_rbd 28 qqkvtlkvnpnstpesllaealr 50
                  ++tl+v+ n++ e+++ ++  
  EFC35828.1 10 GRTITLEVESNDSIENVKRKVQD 32
                5689*********9999887655 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0017
                 -SEEEEEEEETTS-HHHHHHHHHHC..H CS
    PI3K_rbd  27 kqqkvtlkvnpnstpesllaealrk..k 52 
                 + +++t++++ n+t+e+++++++ k   
  EFC35828.1  85 TGKTITIEMESNDTVENMKQKIFDKegI 112
                 46799******************99442 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 4.4
                 HHCT--EEEEEE CS
    PI3K_rbd  92 lksgrephLvLv 103
                 l++++++hLvL+
  EFC35828.1 137 LQKDSTVHLVLR 148
                 678888999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       665  (0.0370907); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.52
# Mc/sec: 883.48
//
Query:       EFC35829.1  [L=101]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-06   27.8   0.1    4.8e-05   22.7   0.1    2.3  2  CHZ       Histone chaperone domain CHZ


Domain annotation for each model (and alignments):
>> CHZ  Histone chaperone domain CHZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.8   0.0    0.0044        79      21      30 ..      27      36 ..      27      39 .. 0.88
   2 !   22.7   0.1   2.7e-09   4.8e-05       9      31 ..      43      63 ..      40      64 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.0044
         CHZ 21 TRgktiDfak 30
                TR+k iD +k
  EFC35829.1 27 TRSKPIDLSK 36
                9******887 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 2.7e-09
         CHZ  9 IDtsNIIsgGRRTRgktiDfaka 31
                IDtsNIIs G R  + +iD+  a
  EFC35829.1 43 IDTSNIIS-GTR-HRNNIDYHHA 63
                *******7.999.99****9766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (101 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1652  (0.0921412); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 639.96
//
Query:       EFC35830.1  [L=116]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.3e-06   25.3   0.2      1e-05   25.0   0.2    1.3  1  Pkinase_Tyr  Protein tyrosine kinase
     0.0037   16.7   0.0     0.0054   16.1   0.0    1.3  1  Pkinase      Protein kinase domain


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.2   1.1e-09     1e-05     212     259 .]      59     108 ..      18     108 .. 0.82

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 1.1e-09
                  HHHHHHHHTTEES-BBTTS..BHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 212 eevleklkegkrlekpekc..peelyelmkkcweedpeeRptfselvekl 259
                  +e++e +++++ l++ + c  +++  elmk+cw++ p++Rp+f+e+++ l
   EFC35830.1  59 REFIEPFEKKNSLDHETVCnvCSDYVELMKQCWNSIPSKRPSFREITQYL 108
                  45777788888877776552268999********************9875 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0     6e-07    0.0054     194     260 ..      45     106 ..       1     108 [. 0.57

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 6e-07
                 S-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 194 kppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellq 260
                 k p++   ++e+ e  l+++       ++++++ ++  ++ ++  +l+k++++  p+kR++++e+ q
  EFC35830.1  45 KIPWN---NNEELEVWLREFI--EPFEKKNSLDHETVCNVCSDYVELMKQCWNSIPSKRPSFREITQ 106
                 22222...4444444444422..2222345555555566699*********************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.29s 00:00:00.72 Elapsed: 00:00:00.47
# Mc/sec: 740.42
//
Query:       EFC35831.1  [L=160]
Description: hypothetical protein NAEGRDRAFT_54720 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.7e-18   64.1  11.6    4.9e-09   36.3   0.3    4.0  4  LRR_4     Leucine Rich repeats (2 copies)
    1.4e-13   50.4   5.3    1.7e-05   24.5   1.3    3.6  3  LRR_8     Leucine rich repeat
    1.5e-13   50.6   0.1    1.3e-06   28.0   0.1    2.1  2  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
        0.2   12.3   9.2    1.1e+02    4.0   0.0    5.0  5  LRR_1     Leucine Rich Repeat
       0.42   10.8   4.9         29    5.0   0.0    4.1  4  LRR_6     Leucine Rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.4   1.4e-08   5.1e-05       1      42 [.       9      49 ..       9      51 .. 0.91
   2 !   36.3   0.3   1.4e-12   4.9e-09       1      42 [.      54      94 ..      54      96 .. 0.92
   3 !   23.4   0.6   1.5e-08   5.5e-05       2      37 ..      77     114 ..      77     118 .. 0.81
   4 ?    2.5   0.0     0.059   2.1e+02      16      29 ..     126     139 ..     120     145 .. 0.84

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 1.4e-08
                SS--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGG CS
       LRR_4  1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeL 42
                +n + L Ls N++  i++l++l +L+ L+L +N +i++l++L
  EFC35831.1  9 KNCKRLALSTNCIDRIGGLQGLVSLEILSLARN-QIKRLENL 49
                689999***66*******************888.***99988 PP

  == domain 2  score: 36.3 bits;  conditional E-value: 1.4e-12
                SS--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGG CS
       LRR_4  1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeL 42
                p Le L+Ls N+lt++ + ekl++Lk+L++ gNn+i++ +e+
  EFC35831.1 54 PTLEQLWLSYNNLTSLAGVEKLKKLKVLYC-GNNKISSWSEI 94
                679***************99**********.999**998775 PP

  == domain 3  score: 23.4 bits;  conditional E-value: 1.5e-08
                 S--EEE--SS---E-S-...HHH-TT--EEE-..-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdL.sgNnlit 37 
                 +L+vL+++nN++++++    l+ lp+L+e+ L +gN +++
  EFC35831.1  77 KLKVLYCGNNKISSWSEidrLKDLPDLEEI-LlTGN-PLE 114
                 79***************655556******8.54888.554 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.059
                 -S-HHH-TT--EEE CS
       LRR_4  16 iplleklpnLkeLd 29 
                 i+ l+ lp+Lk+Ld
  EFC35831.1 126 IEVLRRLPSLKKLD 139
                 5566669****997 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   6.8e-09   2.4e-05      19      61 .]       3      43 ..       2      43 .. 0.93
   2 !   24.5   1.3   4.7e-09   1.7e-05       1      61 []      54     113 ..      54     113 .. 0.90
   3 ?    0.4   0.0      0.16   5.6e+02      45      55 ..     129     139 ..     125     139 .. 0.56

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 6.8e-09
                TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8 19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                ++ ++++n k L Ls N+++++  g ++gL sL+ L L +N++
  EFC35831.1  3 TTVSQMKNCKRLALSTNCIDRI--GGLQGLVSLEILSLARNQI 43
                567889****************..7****************98 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 4.7e-09
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 p+L+ L Ls N+ltsl     ++l++LkvL+ +nN++++  + + + +Lp L+++ L+gN+L
  EFC35831.1  54 PTLEQLWLSYNNLTSLAG--VEKLKKLKVLYCGNNKISSwSEIDRLKDLPDLEEILLTGNPL 113
                 68999***********86..467****************555589***************97 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.16
                 GTT--S-.EEE CS
       LRR_8  45 fsgLpsLrsLd 55 
                 ++ LpsL++Ld
  EFC35831.1 129 LRRLPSLKKLD 139
                 45566666554 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.1   3.6e-10   1.3e-06      47     115 ..      14      81 ..       3      84 .. 0.92
   2 !   24.9   0.0   3.3e-09   1.2e-05      86     161 ..      74     154 ..      73     159 .. 0.88

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 3.6e-10
       LRR_9  47 idlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkl 115
                 + ls n i ++ g+  l  l++l+l+ n+i r+ e+l+ v P+le+l l+ n+l++la ++ l +lk l
  EFC35831.1  14 LALSTNCIDRIGGLQGLVSLEILSLARNQIKRL-ENLDAVAPTLEQLWLSYNNLTSLAGVEKLKKLKVL 81 
                 57999*************************998.79*************************99999977 PP

  == domain 2  score: 24.9 bits;  conditional E-value: 3.3e-09
       LRR_9  86 vlPnleelvltnnelqeladldPlaslkklellsllknpvtnk.....keyrlyviyklkqlrlldfrkvklkereeaekl 161
                  l +l+ l   nn++ + +++d l +l++le + l  np+ ++     +++r  v+ +l++l+ ld r   l+ere+ae +
  EFC35831.1  74 KLKKLKVLYCGNNKISSWSEIDRLKDLPDLEEILLTGNPLEKNtkdagENWRIEVLRRLPSLKKLDGRPFDLAEREQAEGV 154
                 5778999999****************************998652233368****************************865 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.8   6.5e+03       3      13 ..      12      22 ..      10      28 .. 0.64
   2 ?    3.6   0.1      0.04   1.4e+02       1      17 [.      32      48 ..      32      52 .. 0.83
   3 ?    4.0   0.0     0.031   1.1e+02       2      14 ..      56      68 ..      55      72 .. 0.86
   4 ?    3.9   0.1     0.032   1.2e+02       1      12 [.      77      88 ..      77     100 .. 0.82
   5 ?    2.9   0.1     0.067   2.4e+02       2      13 ..     103     114 ..     102     138 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.8
       LRR_1  3 rhLdLsnnpll 13
                ++L Ls n+++
  EFC35831.1 12 KRLALSTNCID 22
                56667777774 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.04
       LRR_1  1 nLrhLdLsnnpllglpp 17
                +L+ L L +n++ +l++
  EFC35831.1 32 SLEILSLARNQIKRLEN 48
                69********9977665 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.031
       LRR_1  2 LrhLdLsnnpllg 14
                L+ L Ls+n+l++
  EFC35831.1 56 LEQLWLSYNNLTS 68
                999*******975 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.032
       LRR_1  1 nLrhLdLsnnpl 12
                +L++L+ +nn +
  EFC35831.1 77 KLKVLYCGNNKI 88
                7*********97 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.067
       LRR_1   2 LrhLdLsnnpll 13 
                 L+++ L++npl+
  EFC35831.1 103 LEEILLTGNPLE 114
                 89999*****94 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.36   1.3e+03       6      16 ..      12      22 ..      12      27 .. 0.79
   2 ?    5.0   0.0    0.0082        29       4      15 ..      32      43 ..      30      44 .. 0.91
   3 ?    4.5   0.1     0.013        45       3      16 ..      54      67 ..      52      76 .. 0.85
   4 ?   -2.1   0.0       1.6   5.8e+03       3       9 ..     133     139 ..     132     139 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.36
       LRR_6  6 teLdLsgNdIg 16
                + L Ls N+I+
  EFC35831.1 12 KRLALSTNCID 22
                5799999**97 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0082
       LRR_6  4 hLteLdLsgNdI 15
                +L+ L+L+ N+I
  EFC35831.1 32 SLEILSLARNQI 43
                79*********9 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.013
       LRR_6  3 thLteLdLsgNdIg 16
                ++L+ L Ls+N+++
  EFC35831.1 54 PTLEQLWLSYNNLT 67
                7999999*****98 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 1.6
       LRR_6   3 thLteLd 9  
                 ++L++Ld
  EFC35831.1 133 PSLKKLD 139
                 689*998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       450  (0.025099); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1029.69
//
Query:       EFC35832.1  [L=576]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-32  110.7  33.5    1.1e-23   83.8  15.3    3.0  3  MFS_1     Major Facilitator Superfamily
    1.2e-09   37.6   4.5    1.2e-09   37.6   4.5    2.7  3  Sugar_tr  Sugar (and other) transporter
    4.5e-05   22.0   0.8    0.00012   20.7   0.8    1.7  1  MFS_3     Transmembrane secretion effector
  ------ inclusion threshold ------
      0.025   15.0   0.2      0.091   13.2   0.2    1.9  1  DUF4094   Domain of unknown function (DUF4094)
       0.07   13.3   0.9       0.67   10.1   0.8    2.7  2  DUF2371   Uncharacterised conserved protein (DUF2371)


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.2     0.016        56     194     230 ..      61     113 ..      41     132 .. 0.58
   2 !   83.8  15.3     3e-27   1.1e-23      22     273 ..     117     415 ..      91     420 .. 0.68
   3 !   30.0  10.7   6.9e-11   2.5e-07      58     172 ..     439     555 ..     435     571 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.016
       MFS_1 194 aplvpawkallkdpvl..........w.......illialllfffgfsglltll 230
                 +p +   + +++d++l          w       il+++ll++f++++++++++
  EFC35832.1  61 KPKLL-CGCIRTDRYLgfielkpgitWvhitcfyILVVILLSMFVFINAMSSYV 113
                 33333.567777776666565555555555554445555555555555555544 PP

  == domain 2  score: 83.8 bits;  conditional E-value: 3e-27
       MFS_1  22 alaedlgispse...igllltlyalgaavaslplGrlsdrf.GrrrvlllglllfalglllllfasslwlllvlrvlqGlgagalfpagaaliadwfpk 116
                 +l  + +  +++   +g l     l  +++ l++G+l+d + Gr+ v+++g+l++++gl+l +fa ++w l++ r++ ++ga++  ++  a++ d+++ 
  EFC35832.1 117 YLRGTVN-RKDQgklAGDLSFYNELCILAFGLIWGVLTDILrGRKFVYMIGFLFMGIGLFLYTFAETIWQLIIYRIIFAIGAASTSSMLTAIVGDYVKN 214
                 4555555.4444333666777788899*************736666************5555599********************************** PP

       MFS_1 117 eergraigllsagfslGailgpllggllasslg...........Wravfyilaivsllafvlfllll.................peepperkrkspkee 187
                 ++rg+a gll+++++lGa++ +l+   +  ++               +f+i+a+++++a+   ++++                 +              
  EFC35832.1 215 KDRGKASGLLGLASGLGAVVSALACLKIPLWIQsadptistgqaGMIAFMIMAFFCIIAMCALMIFFkgrifpicdskqereatR-------------- 299
                 ********************98887744433335557777765555679999999999955333444566666555444443332.............. PP

       MFS_1 188 e...........kgtgpaplvp........awkallkdpvlw...illialllfffgfsg....lltllply....lqevlgls...glllaglllall 253
                 +              +++++++        +w+ l+  p      +l++a +++ f+  g    ++t+++l+    + + ++ s   +   +g++++++
  EFC35832.1 300 RemaessdceeeDDEERFNIKKsfirfkniIWEGLFVAP--AkrpSLILAYISG-FVARGdsilITTFITLWvsqqMIDIHDSSkadATARGGTISGIC 395
                 033455555554223444444433334444455555555..1555555555555.47777778888888887555556666666***77********** PP

       MFS_1 254 alvgailallagrlsdrlgr 273
                 + +++i+a+++g ++d   r
  EFC35832.1 396 QTFALIAAPFVGIFADLRFR 415
                 ***************76333 PP

  == domain 3  score: 30.0 bits;  conditional E-value: 6.9e-11
       MFS_1  58 rfGrrrvlllglllfalglllllfa.sslw.lllvlrvlqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggllasslgWravf 154
                 +++r  v+ +  +++++g ++l+f       ++++  +l G+g+ +++  +++l+++ +p + rg++ g+++++ ++G++++  +gg+l + +  +++f
  EFC35832.1 439 KMSRLIVMAIVSAISGVGYTMLSFLtDVTGgFVYLPIALIGIGEIGVIICSQILVTAESPSKVRGSVSGIFTLFGAAGILVATKVGGYLFDDWKPSGPF 537
                 68777799999999999966777753334457999999************************************************************* PP

       MFS_1 155 yilaivsllafvlfllll 172
                 ++ +++ + +f++ + ++
  EFC35832.1 538 LFYGVLNFALFIISIGFI 555
                 ***********9866666 PP

>> Sugar_tr  Sugar (and other) transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   4.5   3.3e-13   1.2e-09      63     257 ..     146     345 ..     134     356 .. 0.81
   2 ?   -0.9   0.0      0.16   5.7e+02       4      73 ..     346     413 ..     343     418 .. 0.68
   3 !    5.3   8.0     0.002       7.2      71     166 ..     438     533 ..     433     563 .. 0.71

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 3.3e-13
                 HHHHHHHHHHT.THHHHHHHHHHHHHHHHHHHH-TTTTSS-TGGGGGHHHHHHHHHHHHHHHHHHHHTTS-SCCHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Sugar_tr  63 slfagllgdrf.GRkkslliaavlfvigavlqaaakgknsvevlivgRvlvGigvGlasvlvPmyisEiApkklRgalvslyqlaitfGilvaaifglg 160
                 +l+ g l+d++ GRk +++i+ +++ ig +l  +a+   ++++li+ R++  ig+  +s + +  ++ + + k Rg+  +l  la  +G +v+a   l+
  EFC35832.1 146 GLIWGVLTDILrGRKFVYMIGFLFMGIGLFLYTFAE---TIWQLIIYRIIFAIGAASTSSMLTAIVGDYVKNKDRGKASGLLGLASGLGAVVSALACLK 241
                 4777888888769***********************...9*******************************************************9999 PP

                 H.HTSS-........TTHHHHHHHCCHHHHHHHHHHGGGS---HHHHHHTT-HH.HHHH.HHHH.HHHCHHHHHHHHHHHHHHHHHHH.....HTTHHH CS
    Sugar_tr 161 l.nktsn........adgwrillglqlvpallllilllflPESPrylvekgkee.eake.vlak.lrgeedadrelaeekdsleaeqeeekaswkells 247
                 +   +++        + g+  ++ ++++  +++++l++f+     + +   k+e ea++  +a+ ++ ee++d+e  ++k+s+ +    +++ w+ l+ 
  EFC35832.1 242 IpLWIQSadptistgQAGMIAFMIMAFFCIIAMCALMIFFK-GRIFPICDSKQErEATRrEMAEsSDCEEEDDEERFNIKKSFIRF---KNIIWEGLFV 336
                 976666689****9999***********************9.56677766666655543133332444466666666666555554...4788888888 PP

                 HSH...HHHH CS
    Sugar_tr 248 sktvrqrlli 257
                      ++ li
  EFC35832.1 337 APAK-RPSLI 345
                 7663.44333 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.16
                 HHHHHHHHHHHHHHCGGGTHHHHHHHHTSTT--SHHHHHH...HHHHHHHTHHHHHHHHHHHHHHHHHHT CS
    Sugar_tr   4 vaalggllfgYdtgvigafltllkfaknfglsksksskeessvlsglivsiflvGaiiGslfagllgdrf 73 
                 +a+++g++   d+ +i +f+tl   + +     ++ssk++++ + g i +i +  a+i + f+g+++d  
  EFC35832.1 346 LAYISGFVARGDSILITTFITLWVSQQMID--IHDSSKADATARGGTISGICQTFALIAAPFVGIFADLR 413
                 566777777777778888888877444444..44444555578888889999888888888888888854 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.002
                 HHTTHHHHHHHHHHHHHHHHHHHH-TTTTSS-TGGGGGHHHHHHHHHHHHHHHHHHHHTTS-SCCHHHHHHHHHHHHHHHHHHHHHHH.HHHHTSS- CS
    Sugar_tr  71 drfGRkkslliaavlfvigavlqaaakgknsvevlivgRvlvGigvGlasvlvPmyisEiApkklRgalvslyqlaitfGilvaaifg.lglnktsn 166
                  +++R  +++i+++++ +g  +  + ++  +   +++   l+Gig  ++ +++ +++   +p k+Rg + +++ l+ ++Gilva+ +g + +++ + 
  EFC35832.1 438 RKMSRLIVMAIVSAISGVGYTMLSFLTDV-TGGFVYLPIALIGIGEIGVIICSQILVTAESPSKVRGSVSGIFTLFGAAGILVATKVGgYLFDDWKP 533
                 56777777888888888887666666633.4444444567999998888888889998899**********************98775144466665 PP

>> MFS_3  Transmembrane secretion effector
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.8   3.3e-08   0.00012      56     144 ..     140     224 ..     137     249 .. 0.88

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 3.3e-08
       MFS_3  56 LPifllsilaGalaDnfdrRkvllavqlllalvsvlltvlaalgllspwlllaltlligiGaalndPaWqAsvgelvkrrdvpaAvaLn 144
                 L i+ + ++ G+l+D++  Rk++ ++  l +   ++l ++a     + w l+++ ++ +iGaa ++    A+vg+ vk++d  +A  L 
  EFC35832.1 140 LCILAFGLIWGVLTDILRGRKFVYMIGFLFMGIGLFLYTFAE----TIWQLIIYRIIFAIGAASTSSMLTAIVGDYVKNKDRGKASGLL 224
                 7788999***************99999988888888877775....68******************************99987776665 PP

>> DUF4094  Domain of unknown function (DUF4094)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   2.5e-05     0.091       5      53 ..     266     316 ..     263     328 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.5e-05
     DUF4094   5 vllLcvasflagll.ftnRlwtvp.sdiirqs.keelkl.vsedcdskdaesr 53 
                 ++++c+++ +a ++ f++R+   p  d  +++  ++ ++  s+dc+++d e+r
  EFC35832.1 266 MAFFCIIAMCALMIfFKGRIF--PiCDSKQEReATRREMaESSDCEEEDDEER 316
                 678999999988765999*98..5334444443344455499****9887777 PP

>> DUF2371  Uncharacterised conserved protein (DUF2371)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.8   0.00019      0.67      44     125 ..      94     183 ..      78     185 .. 0.60
   2 ?   -1.7   0.0      0.84     3e+03      50      67 ..     267     294 ..     256     326 .. 0.48

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00019
     DUF2371  44 lllGllvllvGiamavlgywpkk...aklaseekssssstaesssekl....gllarfleqylysdkl.kvlGPlimGiGiflfiCanav 125
                 +l+ +l+++     a+ +y  ++    +++++++ + +++ +  +e +    gl+  +l++ l  +k+  ++G l mGiG+fl+  a+++
  EFC35832.1  94 ILVVILLSMFVFINAMSSYVFEAylrGTVNRKDQGKLAGDLSFYNELCilafGLIWGVLTDILRGRKFvYMIGFLFMGIGLFLYTFAETI 183
                 44444444444444555555555333233333333334444443333355666677777777777765269*************999887 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.84
     DUF2371  50 vllvGiamavlgywpkk..........a 67 
                   +  iam+ l  + k           +
  EFC35832.1 267 AFFCIIAMCALMIFFKGrifpicdskqE 294
                 3333455555554444444444433331 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1061  (0.0591779); expected 358.6 (0.02)
Passed bias filter:                      514  (0.0286686); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.48
# Mc/sec: 3606.66
//
Query:       EFC35833.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-44  151.9   1.6    1.5e-44  151.7   1.6    1.1  1  Pyrophosphatase  Inorganic pyrophosphatase


Domain annotation for each model (and alignments):
>> Pyrophosphatase  Inorganic pyrophosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  151.7   1.6   8.1e-49   1.5e-44       1     160 []      57     255 ..      57     255 .. 0.93

  Alignments for each domain:
  == domain 1  score: 151.7 bits;  conditional E-value: 8.1e-49
                      EEEEE-TTCSEEEEEETTT...........TEEEEEEE-SSSB-BSSEEEEETT--BT....................CCBEETSSSEEEEEES CS
  Pyrophosphatase   1 vvvEiprgsnaKyeidkee...........gklrldrvlftskgypanYGfipqTled....................telkGDgDPlDvlvlg 63 
                      +v Eip+++ +K+e++++e           gklr      ++ g+p+nYG++pqT+ed                      ++GD+DP+Dv++++
       EFC35833.1  57 FVNEIPMHTLKKMEVNTKEqfnpiiqdekkGKLREFTYRLDAGGIPFNYGMLPQTWEDpkklihvpfgqvkdgvyqptVAVQGDNDPIDVVEIS 150
                      689***************************9****9*****************************************999************** PP

                      SS---TTEEEEEEEEEEEEEEETTEEEEEEE..EEETTSGGG.T...T-SSGGGSTHHHHHHHHHHHHHTTTTSCCT-SE.EEE.EEEEHHHHH CS
  Pyrophosphatase  64 eeplspgevvevkvlGvlamiDegetDdKii..avpvkdprl.k...kindiedlpgllleeiehfFetykdlegkkknv.kve.ewkdkeeAe 149
                      +++l++gev+++kv G+lamiDege+D+K+i  +v+++++++ +   +++di d+p+  +++i ++F++yk+ +gk +n+  ++ ++ dk++A+
       EFC35833.1 151 DVALEMGEVYKIKVFGILAMIDEGEMDWKVIgrVVSESETSTlQpdeDLQDIYDIPKGKINDIIDWFRMYKTTDGKPENHfGFNtTVLDKAYAK 244
                      *******************************88787774433343448888888********************9966888************* PP

                      HHHHHHHHHHH CS
  Pyrophosphatase 150 kvieeaheryk 160
                      ++i+++h++++
       EFC35833.1 245 HIINQTHKHWS 255
                      *********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       534  (0.0297841); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1626.49
//
Query:       EFC35834.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.5   0.0        0.2   11.6   0.0    1.4  1  APC_u13   Unstructured region on APC between APC_crr and SAMP


Domain annotation for each model (and alignments):
>> APC_u13  Unstructured region on APC between APC_crr and SAMP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   1.1e-05       0.2       7      32 ..      97     122 ..      96     126 .] 0.94

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.1e-05
     APC_u13   7 ELanaesvstGaesaefEkRDtiPTE 32 
                 EL n  ++s+G ++  f k  tiPTE
  EFC35834.1  97 ELNNQSETSSGRKKSLFKKAQTIPTE 122
                 999**********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1016  (0.056668); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 794.10
//
Query:       EFC35835.1  [L=149]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      9e-20   71.6   0.2    1.2e-19   71.2   0.2    1.2  1  Ribosomal_L27A  Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27


Domain annotation for each model (and alignments):
>> Ribosomal_L27A  Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.2   0.2     7e-24   1.2e-19       3     127 ..      28     146 ..      26     147 .. 0.85

  Alignments for each domain:
  == domain 1  score: 71.2 bits;  conditional E-value: 7e-24
                     GGTSSTTTTTTTTT-..S--........S--.........---GGG..---EEEEHHHHHHTTTTGTTS--......----EEEGGGTTTTSSS. CS
  Ribosomal_L27A   3 ktgGrGhkGqkkrsg..vkk.kpg.feGGqmplyrrlpkrGfknskfkkeykvvnlkdLdelideerlela......deaeeidleelaeaglik 87 
                     ++gGrG++G +++++  v++ +pg f  G+      + ++++++++    ++ +n+++L++++ +e+ ++a      ++a +id+ +        
      EFC35835.1  28 HPGGRGMAGGQHHHRiwVDRfHPGyF--GKI----GIRRFHMNKNH--FLTNCLNVDELWKVAGQEVYQQAkegkfgGKAVVIDAHKA------- 107
                     78*************999999***89..**9....44444554433..44489**************995558887777888888888....... PP

                     ...SE.EEE--S---..--EEEESEE-HHHHHHHHHTT-EEE CS
  Ribosomal_L27A  88 kkdgv.Kvlgkgeltk.klkvkaskfSkkAkekIeaaGGkve 127
                        g+ K++g+g+l+k ++ v+a+ fSk+A+ekI+a GG +e
      EFC35835.1 108 ---GFdKIMGRGDLPKiPIVVRARLFSKSAEEKIKAIGGVCE 146
                     ...***********9967**********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       402  (0.0224218); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.26s 00:00:00.71 Elapsed: 00:00:00.44
# Mc/sec: 1020.02
//
Query:       EFC35836.1  [L=246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-22   78.5   0.0    1.2e-21   76.5   0.0    2.0  3  EFG_C     Elongation factor G C-terminus
    8.7e-21   73.9   0.0    1.2e-20   73.4   0.0    1.2  1  EFG_IV    Elongation factor G, domain IV


Domain annotation for each model (and alignments):
>> EFG_C  Elongation factor G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       1.8   1.6e+04      27      38 ..      13      24 ..      12      28 .. 0.77
   2 !   76.5   0.0   1.3e-25   1.2e-21       2      86 ..     125     210 ..     124     213 .. 0.97
   3 ?   -1.4   0.0      0.27   2.4e+03      14      34 ..     212     232 ..     208     234 .. 0.79

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 1.8
                HCT-EEEEEEEE CS
       EFG_C 27 srrGeiedmeqd 38
                ++r++i++++ +
  EFC35836.1 13 NKRAKILEIDFE 24
                689999998865 PP

  == domain 2  score: 76.5 bits;  conditional E-value: 1.3e-25
                 EEEEEEEEEEEEECCCCCCHHHHHHHCT-EEEEEEEE..TTEEEEEEEEEGGG-TTHHHCHHHCTTTS-EEEEEEEEEEE--HHHH CS
       EFG_C   2 llEPivkveievpeeyvgkvisdlssrrGeiedmeqd.asgrviieaeiPlaeligfateLrslTkGegsfsmefsgYeevpgdkl 86 
                 l+EP++ ve+++p++++g v+s +s+rrG i+++e   ++  v i++++P+ e++g+ +eLr +T+G++  +++fs+++ ++ ++ 
  EFC35836.1 125 LVEPMYLVEVQCPQSVMGSVYSVISNRRGVIKSTEMViGTPLVSITGNLPVLESFGLTEELRGVTQGQAFPQCSFSHWKVMEDNVY 210
                 89**********************************999******************************************99876 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.27
                 ECCCCCCHHHHHHHCT-EEEE CS
       EFG_C  14 peeyvgkvisdlssrrGeied 34 
                 p++ v k i+++ +r+G  ed
  EFC35836.1 212 PQSKVHKLIKSIRKRKGLKED 232
                 777788999999999997665 PP

>> EFG_IV  Elongation factor G, domain IV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.4   0.0   1.4e-24   1.2e-20      12     120 ..      11     121 ..       5     122 .. 0.96

  Alignments for each domain:
  == domain 1  score: 73.4 bits;  conditional E-value: 1.4e-24
                 -CCHCCCCCCCHTSSSHCCCCCEEEECCTTTTSSEEEEE--STCCCHCCCCHHHHCCCCCCTTS-TTTS--EESEEEEEEEEE--T..TTC-HHHHHHH CS
      EFG_IV  12 pvkereeklkkqsggdgqyakvileiePleegsgnefvdetkggqvpkeyieavekGfqealkeGplagepvtdvkvtLldgslhe..vdsseaafkpa 108
                 ++++r+++l    ++d+   k i++++P+  +++n++v++tk + + +e++++v++ fq+   +G l++e +++v +++ d+ lh+  ++++++++ +a
  EFC35836.1  11 DQNKRAKILEIDFEWDPSITKRIWSFGPEADKGSNILVNATKSVDYINEIQQYVVTSFQQSSSSGGLCDEAMRGVLFKFNDCNLHAdsIHRGAGQILQA 109
                 556699********************************************************************************************* PP

                 HCHHHHHHHHCC CS
      EFG_IV 109 arralkeallkA 120
                 ++r++ ++ l+A
  EFC35836.1 110 TSRVMTASQLRA 121
                 *******99988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       466  (0.0259914); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1549.86
//
Query:       EFC35837.1  [L=269]
Description: silent information regulator family protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.2e-47  161.3   0.0    2.6e-47  161.0   0.0    1.1  1  SIR2           Sir2 family
  ------ inclusion threshold ------
      0.083   13.1   2.2       0.26   11.5   2.2    1.8  2  FYVE_2         FYVE-type zinc finger
       0.42   10.6   2.9        2.7    8.0   2.9    2.2  1  zinc_ribbon_4  zinc-ribbon domain


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  161.0   0.0   4.4e-51   2.6e-47       8     177 .]       1     182 [.       1     182 [. 0.93

  Alignments for each domain:
  == domain 1  score: 161.0 bits;  conditional E-value: 4.4e-51
                 GT---SSS.TTSHHHHSCHHHHSSHHHHHHHHHHHHH..HHHHHHHHHHCCTSS--HHHHHHHHHHHTTCEEEEEES-SSSHHHHTT-S..SEEETTEE CS
        SIR2   8 sGipdfRs.keGlyaklakeelaspealfskkllvee..vfyniarellaeeaepnaaHkalkklekkgkllrliTQNiDgLekkaGsk..kvvelHGs 101
                 +GipdfR   +Gly++l+k++l +p+a+f+ k+l ++  +f ++ r+ ++  ++p++aH+++k le+k+kl+rl+TQNiDgLe k+G++  ++v++HG 
  EFC35837.1   1 AGIPDFRTpGTGLYDNLQKYNLPHPTAIFELKYLPTNphPFFHLSRDFISSGYKPTKAHYFIKLLEEKNKLKRLYTQNIDGLEAKSGITkeHLVNCHGM 99 
                 6*******9*************************999999************************************************9899******* PP

                 EEEEEETTTSBEEECCGGHCHHH...CCTT.B-TTTCCBEEEEE--CTSB-SHHHHHHHH.HH...HH-SEEEEES--STSTT CS
        SIR2 102 lakakcvkcekkldkeelqeeie...aekvpecekcgkllkpdvvfFGealpdklkklie.kv...eeadlllviGtSlkVap 177
                     +c++c+k+++ +e+ +++    + ++p+c+kcg+++kpd+v+FGe+lp+k+ ++++ ++   +++++++viGtSl+V+p
  EFC35837.1 100 YDIGHCIECSKEYSLSEIVKKMGtdeEVQIPKCDKCGHIVKPDIVLFGESLPNKYVDCCKsDLlrsKDCEVFIVIGTSLSVYP 182
                 ******************9999732244678*********************9999988865433389*************98 PP

>> FYVE_2  FYVE-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   2.2   4.3e-05      0.26      15      90 ..      65     140 ..      55     168 .. 0.77
   2 ?   -1.6   0.0      0.49   2.9e+03      67      96 ..     228     257 ..     226     261 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 4.3e-05
      FYVE_2  15 vqrdeklrkkeeeRlgelkeklekekskrellgnqaklgethCilCleefkllvnskrqCldCklnv..CkkCsvenk 90 
                 ++  +kl++   + ++ l  k     +k++l+  +  +   hCi C +e+ l    k++ +d ++++  C kC++  k
  EFC35837.1  65 LEEKNKLKRLYTQNIDGLEAKS--GITKEHLVNCHGMYDIGHCIECSKEYSLSEIVKKMGTDEEVQIpkCDKCGHIVK 140
                 5555666666666666666665..55677777777788899***********99999999887666555999*98755 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.49
      FYVE_2  67 lvnskrqCldCklnvCkkCsvenkkekvwl 96 
                 l  ++   ++C  ++Ck  + e + e+ ++
  EFC35837.1 228 LGGEDSSIDECVEKLCKLLGWEAELEELYV 257
                 555666778899999998888877777775 PP

>> zinc_ribbon_4  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   2.9   0.00045       2.7       4      34 ..     104     138 ..     103     140 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00045
  zinc_ribbon_4   4 tCpsCkakyeidd..eklp.akgvkv.rCskCghv 34 
                    +C +C+++y++++  +k+  ++ v + +C kCgh+
     EFC35837.1 104 HCIECSKEYSLSEivKKMGtDEEVQIpKCDKCGHI 138
                    699********99334444433333358*****97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1839.88
//
Query:       EFC35838.1  [L=165]
Description: PFAM domain(EF-Hand)-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.8e-23   81.7   9.2    9.9e-12   45.1   1.6    3.0  3  EF-hand_7     EF-hand domain pair
    8.7e-23   78.1   4.3    3.6e-05   23.0   0.3    4.2  4  EF-hand_1     EF hand
    2.3e-20   70.7   3.3    0.00024   20.8   0.0    4.2  4  EF-hand_6     EF-hand domain
    9.6e-17   60.6   4.9    1.3e-05   24.9   0.0    3.5  4  EF-hand_8     EF-hand domain pair
    1.5e-15   55.8   1.7     0.0011   18.3   0.1    4.2  4  EF-hand_5     EF hand
    1.9e-07   30.8   1.2    0.00019   21.3   0.0    3.4  3  EF-hand_10    EF hand
      0.004   17.5   2.2        3.8    7.9   0.5    3.1  3  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
  ------ inclusion threshold ------
      0.026   14.5   1.9       0.17   11.9   0.5    2.3  2  EF-hand_4     Cytoskeletal-regulatory complex EF hand
      0.034   14.4   1.1      0.067   13.5   0.1    1.9  2  MecA_N        NTF2-like N-terminal transpeptidase domain
       0.08   12.8   2.8       0.34   10.8   0.1    2.2  2  IFN-gamma     Interferon gamma


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.1   1.6   5.5e-15   9.9e-12       2      69 ..      11      73 ..      10      75 .. 0.95
   2 !   19.3   0.0   6.2e-07    0.0011      46      71 .]     100     125 ..      79     125 .. 0.84
   3 !   33.6   0.2   2.2e-11     4e-08       8      70 ..     104     162 ..     103     163 .. 0.91

  Alignments for each domain:
  == domain 1  score: 45.1 bits;  conditional E-value: 5.5e-15
   EF-hand_7  2 eklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkl 69
                ++++  Fk++D+d++++++ +e+++l+ +     + g ++sd+ l ++   +D+d+dG+isfdEF ++
  EFC35838.1 11 SVIHSLFKKYDQDNSNSINISEMKNLFVA-----DMGINFSDDNLMAIQMYMDKDSDGKISFDEFFNY 73
                789**********************9999.....*******************************876 PP

  == domain 2  score: 19.3 bits;  conditional E-value: 6.2e-07
   EF-hand_7  46 lellfkefDtdkdGvisfdEFlklyr 71 
                   llfk+ Dt+++++is++EF+ +y+
  EFC35838.1 100 AALLFKNTDTSGNRQISREEFVSFYQ 125
                 6789********************97 PP

  == domain 3  score: 33.6 bits;  conditional E-value: 2.2e-11
   EF-hand_7   8 FkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkly 70 
                 Fk  Dt g+  +++ee+ +++++++       ++ d  +++ ++ +Dtdk+G++sf+E+ ++ 
  EFC35838.1 104 FKNTDTSGNRQISREEFVSFYQQLYN--NYSANMAD--IDYALNYIDTDKSGSLSFQELINWL 162
                 999********************976..67777777..*********************9986 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   2.6e-07   0.00047       2      26 ..      13      37 ..      12      39 .. 0.90
   2 !   23.0   0.3     2e-08   3.6e-05       9      28 ..      57      76 ..      55      77 .. 0.90
   3 !   13.4   0.0   2.4e-05     0.043       6      27 ..     104     125 ..     102     127 .. 0.89
   4 !   21.2   0.0   7.5e-08   0.00013       1      27 [.     137     163 ..     137     163 .. 0.92

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 2.6e-07
                HHHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1  2 lkeiFrefDkDgdGkIdfeEfkell 26
                +  +F+++D+D++  I+++E+k+l+
  EFC35838.1 13 IHSLFKKYDQDNSNSINISEMKNLF 37
                5679******************987 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 2e-08
                HTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1  9 fDkDgdGkIdfeEfkellkk 28
                +DkD dGkI+f+Ef +++++
  EFC35838.1 57 MDKDSDGKISFDEFFNYWTT 76
                8*************999876 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 2.4e-05
                 HHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   6 FrefDkDgdGkIdfeEfkellk 27 
                 F+  D+ g+ +I++eEf+++ +
  EFC35838.1 104 FKNTDTSGNRQISREEFVSFYQ 125
                 9999**************9865 PP

  == domain 4  score: 21.2 bits;  conditional E-value: 7.5e-08
                 HHHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellk 27 
                 +++ + + +D+D++G ++f+E++++l+
  EFC35838.1 137 DIDYALNYIDTDKSGSLSFQELINWLR 163
                 588999*****************9986 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.1   3.6e-07   0.00065       2      26 ..      13      37 ..      12      42 .. 0.91
   2 !   14.7   0.1   1.2e-05     0.021       8      24 ..      56      72 ..      52      80 .. 0.87
   3 !   13.8   0.0   2.3e-05     0.041       5      28 ..     103     126 ..     102     133 .. 0.91
   4 !   20.8   0.0   1.3e-07   0.00024       2      27 ..     138     163 ..     137     165 .] 0.93

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 3.6e-07
   EF-hand_6  2 lreaFklfDkdgdGkidaeElrkal 26
                ++++Fk++D+d++++i+++E+++++
  EFC35838.1 13 IHSLFKKYDQDNSNSINISEMKNLF 37
                679******************9876 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.2e-05
   EF-hand_6  8 lfDkdgdGkidaeElrk 24
                ++Dkd dGki+++E+ +
  EFC35838.1 56 YMDKDSDGKISFDEFFN 72
                57************965 PP

  == domain 3  score: 13.8 bits;  conditional E-value: 2.3e-05
   EF-hand_6   5 aFklfDkdgdGkidaeElrkalrk 28 
                 +Fk  D++g+ +i++eE+++++++
  EFC35838.1 103 LFKNTDTSGNRQISREEFVSFYQQ 126
                 69******************9985 PP

  == domain 4  score: 20.8 bits;  conditional E-value: 1.3e-07
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalr 27 
                 +++a +++D+d++G+++++El+++lr
  EFC35838.1 138 IDYALNYIDTDKSGSLSFQELINWLR 163
                 678999*******************8 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0   6.1e-05      0.11      25      52 ..      10      37 ..       2      39 .. 0.87
   2 !   22.6   2.7     4e-08   7.2e-05      15      53 ..      39      75 ..      32      76 .. 0.88
   3 !    6.7   0.0    0.0037       6.6      31      53 ..     103     125 ..     102     127 .. 0.84
   4 !   24.9   0.0   7.5e-09   1.3e-05       3      50 ..     113     160 ..     111     163 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.1e-05
   EF-hand_8 25 eeevdilfrefDtdgdGkisfeEFcvll 52
                 + +++lf++ D+d+++ i+  E  +l+
  EFC35838.1 10 RSVIHSLFKKYDQDNSNSINISEMKNLF 37
                56799***************99988887 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 4e-08
   EF-hand_8 15 rilglkkglseeevdilfrefDtdgdGkisfeEFcvlle 53
                + +g++  +s++++ ++ +++D d dGkisf+EF+++++
  EFC35838.1 39 ADMGIN--FSDDNLMAIQMYMDKDSDGKISFDEFFNYWT 75
                667889..9999999**********************96 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0037
   EF-hand_8  31 lfrefDtdgdGkisfeEFcvlle 53 
                 lf+  Dt g+  is eEF+ +++
  EFC35838.1 103 LFKNTDTSGNRQISREEFVSFYQ 125
                 78888999999999999999877 PP

  == domain 4  score: 24.9 bits;  conditional E-value: 7.5e-09
   EF-hand_8   3 gkItreelrrilrilglkk.glseeevdilfrefDtdgdGkisfeEFcv 50 
                  +I+ree+++++  l ++  + +  ++d  ++++Dtd++G +sf E ++
  EFC35838.1 113 RQISREEFVSFYQQL-YNNySANMADIDYALNYIDTDKSGSLSFQELIN 160
                 69********99443.44478*************************886 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.0   3.2e-05     0.057       3      24 ..      15      36 ..      13      38 .. 0.88
   2 !   18.3   0.1   6.4e-07    0.0011       8      21 ..      57      70 ..      55      77 .. 0.93
   3 ?    4.0   0.0     0.022        39      15      24 ..     114     123 ..     103     127 .. 0.85
   4 !   17.1   0.0   1.5e-06    0.0027       4      22 ..     141     159 ..     138     162 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.2e-05
                HHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeELktl 24
                 +F++ D +++  I+++E k+l
  EFC35838.1 15 SLFKKYDQDNSNSINISEMKNL 36
                58*****************994 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 6.4e-07
                H-SS-SSCE-HHHH CS
   EF-hand_5  8 iDlNgDGkIskeEL 21
                +D++ DGkIs++E+
  EFC35838.1 57 MDKDSDGKISFDEF 70
                8************9 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.022
                 CE-HHHHHHH CS
   EF-hand_5  15 kIskeELktl 24 
                 +Is+eE+  +
  EFC35838.1 114 QISREEFVSF 123
                 6******655 PP

  == domain 4  score: 17.1 bits;  conditional E-value: 1.5e-06
                 HHHHH-SS-SSCE-HHHHH CS
   EF-hand_5   4 tFqaiDlNgDGkIskeELk 22 
                 +++ iD++++G +s++EL 
  EFC35838.1 141 ALNYIDTDKSGSLSFQELI 159
                 4789*************95 PP

>> EF-hand_10  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.1     0.007        13      25      45 ..      15      35 ..      13      41 .. 0.88
   2 !   21.3   0.0     1e-07   0.00019      21      50 .]      98     127 ..      97     127 .. 0.96
   3 ?    0.2   0.0      0.39   6.9e+02      32      47 ..     147     162 ..     143     165 .] 0.55

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.007
  EF-hand_10 25 kLFkkcDkSksgrLegeEiee 45
                +LFkk D+ +s++++ +E+++
  EFC35838.1 15 SLFKKYDQDNSNSINISEMKN 35
                79************9999875 PP

  == domain 2  score: 21.3 bits;  conditional E-value: 1e-07
  EF-hand_10  21 eYAekLFkkcDkSksgrLegeEieeFyklL 50 
                  YA  LFk+ D+S + ++  eE++ Fy++L
  EFC35838.1  98 TYAALLFKNTDTSGNRQISREEFVSFYQQL 127
                 5**************************987 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.39
  EF-hand_10  32 kSksgrLegeEieeFy 47 
                 + ksg+L  +E+ + +
  EFC35838.1 147 TDKSGSLSFQELINWL 162
                 5556666555554444 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.5    0.0021       3.8      53     111 ..      10      71 ..       2      73 .. 0.78
   2 ?    3.5   0.0     0.048        87      93     111 ..     103     121 ..      98     123 .. 0.88
   3 ?    3.4   0.0     0.052        93      47      77 ..     129     159 ..     122     163 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0021
  SPARC_Ca_bdg  53 kepvawkFsklDtnsdkvlsksELaplrap...lvklehCikpflescDadkdkkislkEwc 111
                   ++ ++  F+k D+++ ++++ sE+++l      +   +    +  +  D d+d+kis  E+ 
    EFC35838.1  10 RSVIHSLFKKYDQDNSNSINISEMKNLFVAdmgINFSDDNLMAIQMYMDKDSDGKISFDEFF 71 
                   5678889*****************99976511155566666777788999*******99996 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.048
  SPARC_Ca_bdg  93 flescDadkdkkislkEwc 111
                   ++++ D+  +++is++E++
    EFC35838.1 103 LFKNTDTSGNRQISREEFV 121
                   79999***********997 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.052
  SPARC_Ca_bdg  47 knlkeckepvawkFsklDtnsdkvlsksELa 77 
                   +n+++    + +  + +Dt++ ++ls +EL 
    EFC35838.1 129 NNYSANMADIDYALNYIDTDKSGSLSFQELI 159
                   5677777889999999************996 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.5   9.3e-05      0.17      38      66 ..      43      71 ..      12      90 .. 0.78
   2 ?    2.0   0.0      0.11   1.9e+02      46      67 ..     139     160 ..     103     165 .] 0.72

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 9.3e-05
   EF-hand_4 38 skleedklekiwdladidedgkldfeefc 66
                 ++++d+l  i    d d+dgk+ f+ef 
  EFC35838.1 43 INFSDDNLMAIQMYMDKDSDGKISFDEFF 71
                46899**********************96 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.11
   EF-hand_4  46 ekiwdladidedgkldfeefci 67 
                 +   +  d d+ g+l f+e++ 
  EFC35838.1 139 DYALNYIDTDKSGSLSFQELIN 160
                 4445566888889999999875 PP

>> MecA_N  NTF2-like N-terminal transpeptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1       1.1   1.9e+03      64      64 ..      58      58 ..      11      84 .. 0.59
   2 ?   13.5   0.1   3.7e-05     0.067      21      67 ..     103     149 ..      98     159 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.1
                E CS
      MecA_N 64 d 64
                d
  EFC35838.1 58 D 58
                2 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 3.7e-05
                 HHCTB--BSSBSS-HHHHHHHHHHHCCCTT-EEEEE.EEEEEEEEETT CS
      MecA_N  21 aasllseqskkeisekeavekyqaiydglqvkklki.eakkvkkdken 67 
                 +++++++    +is++e+v+ yq+ y++ +++  +i + +  + d ++
  EFC35838.1 103 LFKNTDTSGNRQISREEFVSFYQQLYNNYSANMADIdY-ALNYIDTDK 149
                 5789999999***********************99952.333333333 PP

>> IFN-gamma  Interferon gamma
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.6     0.082   1.5e+02      15      56 ..      28      68 ..      10      93 .. 0.65
   2 ?   10.8   0.1   0.00019      0.34      42      85 ..     104     148 ..      97     157 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.082
   IFN-gamma 15 keiekLkeYfnasssdvadggsLfldilknwkeesdkkilqs 56
                 +i ++k+ f a+ + +  +++ ++ i + + ++sd ki   
  EFC35838.1 28 INISEMKNLFVAD-MGINFSDDNLMAIQMYMDKDSDGKISFD 68
                4677788888765.4555555556677777888888888655 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00019
   IFN-gamma  42 lknwkeesdkkilqsqivsfYfklFeklkdnq.viqksletiked 85 
                 +kn    ++++i + + vsfY +l++++  n   i  +l+ i  d
  EFC35838.1 104 FKNTDTSGNRQISREEFVSFYQQLYNNYSANMaDIDYALNYIDTD 148
                 6899999********************997651588777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       994  (0.0554409); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 975.22
//
Query:       EFC35839.1  [L=416]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1374  (0.0766356); expected 358.6 (0.02)
Passed bias filter:                      693  (0.0386525); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 2292.37
//
Query:       EFC35840.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-51  174.4   0.7    2.3e-51  174.1   0.7    1.1  1  adh_short        short chain dehydrogenase
    2.6e-37  128.6   0.4    3.3e-37  128.3   0.4    1.0  1  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
      4e-11   43.1   0.2    5.6e-11   42.7   0.2    1.1  1  KR               KR domain
    2.9e-05   23.6   0.2    4.3e-05   23.1   0.2    1.4  1  Epimerase        NAD dependent epimerase/dehydratase family
    0.00073   18.8   0.7    0.00097   18.4   0.7    1.1  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
  ------ inclusion threshold ------
      0.022   14.6   0.3       0.04   13.8   0.3    1.5  1  NAD_binding_10   NAD(P)H-binding
      0.029   13.8   0.1      0.054   12.9   0.1    1.6  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  174.1   0.7   8.9e-55   2.3e-51       1     189 [.       7     198 ..       7     203 .. 0.97

  Alignments for each domain:
  == domain 1  score: 174.1 bits;  conditional E-value: 8.9e-55
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHHHHHHHH.SSESEEEE---SS--SSGGGC CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealvekavkkl.gkldvLvnNAGitgsgpfsel 96 
                 k v++tGassGIG a+a  +a++G+k+++++r++++lee+++  +    +++ l+ q+Dvt+ e++++ ve a kk+  ++d+++nNAGi +s+p se 
  EFC35840.1   7 KLVVITGASSGIGEATAVLFAQKGYKLLLLARRKDRLEELVNDSRYSfnQDNTLIHQCDVTNVEDIRTGVELATKKFnLPVDCFINNAGIGHSSPLSEQ 105
                 689****************************************999998889*************************89******************** PP

                 SHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHHHHH CS
   adh_short  97 seeewervievNltgvflltravlpamlkqssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakelaptgirvnavaPGlvdTdmake 189
                 s ++  +vi+vN++gv++ +  v++ m+++++G+I+n+sS+ag++ + g ++Y+ sK+av++++++l+ e+a++++rv+++ PG+++++++  
  EFC35840.1 106 SLDKQYAVIDVNIKGVLNGINVVAKDMVQRQAGTIINISSIAGRKTMDGASVYCGSKFAVHAISETLRSEVASSKVRVVVISPGVTESEITGH 198
                 ***************************************************************************************999865 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.3   0.4   1.3e-40   3.3e-37       1     213 [.      13     229 ..      13     232 .. 0.96

  Alignments for each domain:
  == domain 1  score: 128.3 bits;  conditional E-value: 1.3e-40
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE...EEE--TTSHHHHHHHHHHHHHHH.SSEEEEEE-----EGCSS-GGGH-H CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgae...vlecDVtdeeqvealveevvekf.gklDilvnnagiapklkgpfletsr 92 
                   Ga sgIG+a+A ++a++G++++l  +++++ ++ v++   +++++   + +cDVt+ e++++ ve +++kf   +D+++nnagi ++  +p+ e s 
    EFC35840.1  13 GASSGIGEATAVLFAQKGYKLLLLARRKDRlEELVNDSRYSFNQDntlIHQCDVTNVEDIRTGVELATKKFnLPVDCFINNAGIGHS--SPLSEQSL 107
                   899******************9999999998**********99776544**********************889*************..******** PP

                   HHHHHHHHHHTHHHHHHHHHHHH.HCTSC.CEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTGGGGSTTHHH CS
  adh_short_C2  93 eefdraldvnlyslfllakaalp.lmkeg.gsivnlssvgaervvpnynaygaaKaalealtrylAvelgpkgiRvNavspgpikTlaasgikgfde 187
                   ++   ++dvn++++++ ++ +++ +++++ g i+n+ss+++++++++ ++y+ +K a++a++ +l  e+++ ++Rv ++spg+++ +++ + ++ +e
    EFC35840.1 108 DKQYAVIDVNIKGVLNGINVVAKdMVQRQaGTIINISSIAGRKTMDGASVYCGSKFAVHAISETLRSEVASSKVRVVVISPGVTESEITGHDEKLHE 204
                   ***********************8888889******************************************************************* PP

                   HHHHHHHHSTTSS-B-HHHHHHHHHH CS
  adh_short_C2 188 lleelearaplgrlgtpeevaeaalf 213
                   + e +++   lg   ++++vae +l+
    EFC35840.1 205 MVEGMKKGLTLGI-LKAQDVAESILY 229
                   ***********98.9*******9987 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.7   0.2   2.2e-14   5.6e-11       3     169 ..       9     178 ..       8     192 .. 0.85

  Alignments for each domain:
  == domain 1  score: 42.7 bits;  conditional E-value: 2.2e-14
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE---------TTT- CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvlrdklleem 100
                 ++itG+  g+G ++a   a+kg + l+l  R+ + +e  ++   ++++   +  + ++Dv++ +++++ +e +++++  p+   i+ Ag+ + ++l+e+
  EFC35840.1   9 VVITGASSGIGEATAVLFAQKGYKLLLLARRKDRLEELVNDSRYSFNQD--NTLIHQCDVTNVEDIRTGVELATKKFnLPVDCFINNAGIGHSSPLSEQ 105
                 68********************987777777755555555555555554..555679********************99******************** PP

                 -HHHHHHHHTTTTHHHHHHHHHTTT....S--SEEEEEEEHHHHH--TT-HHHHHHHHHHHHHHHHHHHHHHT CS
          KR 101 taedleqvlapKvkGawnLhelled....esldffvlfSSiagllgsagqanYaaaNaflDalaeyrrsqglp 169
                 + ++  +v+   +kG+ n  +++++    ++   ++ +SSiag   + g + Y      ++a+ e+ rs+ ++
  EFC35840.1 106 SLDKQYAVIDVNIKGVLNGINVVAKdmvqRQAGTIINISSIAGRKTMDGASVYCGSKFAVHAISETLRSEVAS 178
                 ***************99976666665777999*********************99988888888888876655 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.2   1.7e-08   4.3e-05       1     123 [.       9     151 ..       9     233 .. 0.74

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.7e-08
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC........EEEE--TT-HH......HHHHHHHHH..T-SEEEE--S---H....HH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl........elveldltdrs......alerlfkee..qpdavihlAavggv....aa 79 
                 +++tGa+  iG a++  +++kgy+++ l+r++++ ++  ++           ++++d+t+ +      +   + k++   +d+ i+ A++g+     ++
  EFC35840.1   9 VVITGASSGIGEATAVLFAQKGYKLLLLARRKDRLEELVNDSRysfnqdntLIHQCDVTNVEdirtgvE--LATKKFnlPVDCFINNAGIGHSsplsEQ 105
                 68*****************************7766666666669******9899999999994444331..2223323489********9996222257 PP

                 HHHSHHHHHHHHTHHHHHHHHHHHHHTCT....EEEEEEEGGGGTSCS CS
   Epimerase  80 ssedpadfieknlqgtlnlleaarkagvk....rllflsSsevYGkda 123
                 s +++ ++i+ n++g+ln ++++ k  v+     ++++sS  + G+++
  EFC35840.1 106 SLDKQYAVIDVNIKGVLNGINVVAKDMVQrqagTIINISS--IAGRKT 151
                 88888899**********9999998877655557777777..666554 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.7   3.8e-07   0.00097       1     166 [.       9     186 ..       9     191 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.8e-07
                      EEEETTTSHHHHHHHHHHHHHB-SEEEEEES-HHHHHHHHHH......-TTE..EEE....E--TT-HHHHHHHTT..T-SEEEE------.HH CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkkkpkkiillerdElklyeiekeleeelkkkkl..kveivpvigdvrdkerlekaleelkvdvvfhaAAlKh.VP 91 
                      v++tGa+  iG++    +++k   k++ll r   +l e+ ++ + +++++++  +   v+ + d+r   +l++   +l vd+ ++ A + h  P
       EFC35840.1   9 VVITGASSGIGEATAVLFAQKGY-KLLLLARRKDRLEELVNDSRYSFNQDNTliHQCDVTNVEDIRTGVELATKKFNLPVDCFINNAGIGHsSP 101
                      79*********998776666655.56666666667777777755555555440133445667777776666555555889**999999988469 PP

                      HHHH...SHHHHHHHHHHHHHHHHHHHHHTT-S....EEEEEEE...GGGSS--SHHHHHHHHHHHHHHHGGG--SSS--EEEEE CS
  Polysacc_synt_2  92 lvee...npleaiktNvlgtenvieaaieagvk....kvvliSt...DKAvnPtnvmGatKrlaekllqalakeseekktkfvvv 166
                      l e+   + + +i+ N+ g  n i++  +  v+    +++ iS+    K ++  +v+  +K +   +  +l++e +++k ++vv+
       EFC35840.1 102 LSEQsldKQYAVIDVNIKGVLNGINVVAKDMVQrqagTIINISSiagRKTMDGASVYCGSKFAVHAISETLRSEVASSKVRVVVI 186
                      999833346789******99987777666555422227899987444799999********999999999999998888887765 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.3   1.5e-05      0.04       1     179 [.      13     229 ..      13     234 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.5e-05
                     TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHH.......CTTTCEEEE--TT-CCHHHHHHT........T-SEEEES---TCC....... CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRnpeklaele.......aeeglevvegdvtdvedlaealk........gadaVvsalggggk....... 73 
                     GA+ ++G + +   +++ g+++ +l+R++++l+el        +++++ + + dvt+ved++  ++         +d  + ++g g++       
      EFC35840.1  13 GASSGIGEATAVLFAQK-GYKLLLLARRKDRLEELVndsrysfNQDNTLIHQCDVTNVEDIRTGVElatkkfnlPVDCFINNAGIGHSsplseqs 106
                     99999**9999866666.7*************96552333333456888999***********99988888877778777777666666765444 PP

                     .HHHH...............HHHHHHHHHHCT--EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEEEEEEE-CEE-S... CS
  NAD_binding_10  74 .deeg...............aknivdaakeagvkRfvlvsaigvgdevpgefgewnkellkaylaakraaeellrasgldwTivrpggLtde... 149
                      d                   + +++ + + +   ++ +s+i  ++  +g+          a++a  +    ++ +s++  ++++pg  + e   
      EFC35840.1 107 lD--KqyavidvnikgvlngINVVAKDMVQRQAGTIINISSIAGRKTMDGASVYC--GSKFAVHAISETLRSEVASSKVRVVVISPGVTESEitg 197
                     43..045788888888888555666788888888899999987665444433222..22235555566666678889999999999988766211 PP

                     .T--SEEEEETTSS-.---EEEHHHHHHHHHH CS
  NAD_binding_10 150 .pttkyrvvekgepf.kggsisradVAdvlva 179
                      +++  ++ve+ ++  + g    +dVA+ ++ 
      EFC35840.1 198 hDEKLHEMVEGMKKGlTLGILKAQDVAESILY 229
                     12333333333332202344577777777765 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   2.1e-05     0.054       2      70 ..      11      75 ..      10     146 .. 0.75
   2 ?   -3.0   0.0       1.4   3.7e+03     149     170 ..     154     175 ..     149     214 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.1e-05
                   EETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGC.CEEEEE--TT-HHHHHHH CS
  GDP_Man_Dehyd  2 iTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeelee.nlklhkgDltDssslerl 70
                   iTG +  iG  +a l+ +kgy+   + rr++      +e+l +d + + ++ n  +h++D+t+ + ++  
     EFC35840.1 11 ITGASSGIGEATAVLFAQKGYKLLLLARRKDR-----LEELVNDSRYSFNQdNTLIHQCDVTNVEDIRTG 75
                   9****9******************99999875.....5566666555555438889******98887654 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.4
                    --SHHHHHHHHHHHHHHHHHHH CS
  GDP_Man_Dehyd 149 PrsPYaaaKlyadwivvnyrea 170
                      s Y  +K + + i +  r +
     EFC35840.1 154 GASVYCGSKFAVHAISETLRSE 175
                    5677777777777776666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 1560.69
//
Query:       EFC35841.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.6e-18   65.0   0.0    6.6e-18   65.0   0.0    2.0  2  PRiA4_ORF3      Plasmid pRiA4b ORF-3-like protein
  ------ inclusion threshold ------
       0.12   12.4  15.5       0.24   11.5  15.5    1.5  1  YL1             YL1 nuclear protein
       0.34    9.1  16.2       0.48    8.6  16.2    1.2  1  Nop14           Nop14-like family
       0.37   11.0   2.0       0.43   10.8   0.1    2.0  3  CCG             Cysteine-rich domain
        1.5    7.3  29.9        2.6    6.5  29.9    1.3  1  TFIIF_alpha     Transcription initiation factor IIF, alpha su
          2    6.8  16.6        2.8    6.3  16.6    1.2  1  SGT1            SGT1 protein
        4.7    7.1  11.9        9.2    6.2  11.9    1.6  1  Pox_RNA_Pol_19  Poxvirus DNA-directed RNA polymerase 19 kDa s


Domain annotation for each model (and alignments):
>> PRiA4_ORF3  Plasmid pRiA4b ORF-3-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   1.6       0.5   1.3e+03      48      89 ..      50      93 ..      34      96 .. 0.58
   2 !   65.0   0.0   2.6e-21   6.6e-18      24     114 ..     132     217 ..     109     244 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.5
  PRiA4_ORF3 48 eFeieekryge..eeeedeeeeeevldeskvklddvlkekgkkl 89
                eFe + + y +   eee  +ee++  +e++  +++v+++k+kk 
  EFC35841.1 50 EFEKRMEMYMKemLEEEGIDEESDESEEETKIVKKVVEPKKKKQ 93
                56665566666442233333444444444455677777777765 PP

  == domain 2  score: 65.0 bits;  conditional E-value: 2.6e-21
  PRiA4_ORF3  24 editlarLhevlqaafgwedyHlheFeieekrygeeeeedeeeeeevldeskvklddvlkekgkkltyeYDfgdsWeheielekvledkee 114
                 ++++l+ Lh++l+ af+w+d Hlh F++ +      e +d++  +e ++esk++ld+vl+++ +++ y+YDf  +W+ +i lek+l+++  
  EFC35841.1 132 QNANLRHLHNLLMYAFDWDDGHLHMFHTCKG-----EFTDRSMCQEGKEESKCRLDSVLNRSVDSIDYVYDFSSEWNISISLEKILTEQAM 217
                 6899************************333.....35668899999***************************************99654 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  15.5   9.5e-05      0.24      13      97 ..       3     100 ..       1     135 [. 0.52

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 9.5e-05
                 xxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxx..............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1  13 kLleqeee...edelellFaEeedDeefeseeeeeeee..............nsDsdfdsdeedeesdeeedeeegekelerqerkkrkkekkkrkaqk 94 
                 kLl++++    +d+ +  +  ++dD +++++e+ eee                 ++ + +  e+e  dee+de+e+e ++ ++  + +   kkk+k ++
  EFC35841.1   3 KLLANKQGsddDDDDD-DYYSDDDDGDYTDDEDGEEELynsgdrtekeefekRMEMYMKEMLEEEGIDEESDESEEETKIVKKVVEPK---KKKQKMES 97 
                 6665554344222222.23446666666666555554466666666665544444444444444444555555555554444444444...22222222 PP

                 xxx RF
         YL1  95 kks 97 
                  +s
  EFC35841.1  98 GQS 100
                 222 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  16.2   0.00019      0.48     352     437 ..      11     104 ..       2     132 .. 0.36

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00019
       Nop14 352 eddfeedddlveseseeeeeeeeedeeeeedeeeeeeeeededdlsdlese.......eeeeedeleeel.....leeekkaaeekkekkkkkkksee 437
                 +dd+++ddd  +++++ +  +++ed eee  ++ +  e+e+ ++ +++ ++        +ee+de eee+     ++e kk++++ +   + +++s++
  EFC35841.1  11 SDDDDDDDDYYSDDDDGD-YTDDEDGEEELYNSGDRTEKEEFEKRMEMYMKemleeegIDEESDESEEETkivkkVVEPKKKKQKME---SGQSASSS 104
                 222222222222222222.23333333332222222111222222222222234445633333333333333432222222222221...22233322 PP

>> CCG  Cysteine-rich domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       2.2   5.6e+03      55      67 ..      52      64 ..      42      83 .. 0.55
   2 ?   -3.6   0.0       5.5   1.4e+04      15      26 ..      76      87 ..      69      96 .. 0.58
   3 ?   10.8   0.1   0.00017      0.43      17      65 ..     213     267 ..     208     269 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.2
         CCG 55 ealakrnvetaee 67
                e+ +++ ++++ e
  EFC35841.1 52 EKRMEMYMKEMLE 64
                3333333333332 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 5.5
         CCG 15 pevrkalkklle 26
                +e +k++kk++e
  EFC35841.1 76 EEETKIVKKVVE 87
                444445555543 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 0.00017
         CCG  17 vrkalkkllealgveleel..ekesCCGagggrsgkee....laealakrnveta 65 
                 +++a+k+  e+l++el+    +  +CCG  gg  ++e      +++++k+n + +
  EFC35841.1 213 TEQAMKAQAEKLNIELPNDltKVVYCCGGLGGSIDEESgkkkGTFDINKENKRKF 267
                 678999999******998767889*******987776654335668888887665 PP

>> TFIIF_alpha  Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  29.9     0.001       2.6     259     358 ..       8     106 ..       3     110 .. 0.40

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.001
                  XXXXXXXXXXXX.XXXX..XX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  TFIIF_alpha 259 kkkrgsdddadeydsdd..Gd....degrEldyisDdsasendpeeredkkseEeeekkeieqdedeeekeeekkeeegklskkkkkakklkkkkkek 350
                  k+  ++ddd+d+y sdd  Gd    + g E+ y s d +++++ e+r ++  +E       e  e+  ++e++++eee k  kk  ++kk+k+k +  
   EFC35841.1   8 KQGSDDDDDDDDYYSDDddGDytddEDGEEELYNSGDRTEKEEFEKRMEMYMKEML-----E--EEGIDEESDESEEETKIVKKVVEPKKKKQKMESG 98 
                  23334444444443333003211112333444444444433333333332222222.....2..2223344445556666777777777666655555 PP

                  ..XXXXXX CS
  TFIIF_alpha 351 dkkdSdde 358
                  +  +S+++
   EFC35841.1  99 QSASSSSG 106
                  44444444 PP

>> SGT1  SGT1 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  16.6    0.0011       2.8     479     567 ..       3      96 ..       1     110 [. 0.63

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0011
        SGT1 479 kllgskieeeldsddld.edssedsdeedeedeeee.ea..eeeskeeekeslksYmdqm.deELaqttvgksFekkkkkkekakkkeekeets 567
                 kll +k+  + d+dd d  ++++d d+ d+ed eee  +  ++++kee ++ ++ Ym++m +eE    + ++s e++k  k+  + k++k++ +
  EFC35841.1   3 KLLANKQGSDDDDDDDDyYSDDDDGDYTDDEDGEEElYNsgDRTEKEEFEKRMEMYMKEMlEEEGIDEESDESEEETKIVKKVVEPKKKKQKME 96 
                 677777777777766666778888888888887776533467888889999******9994445555556666666655554444444333332 PP

>> Pox_RNA_Pol_19  Poxvirus DNA-directed RNA polymerase 19 kDa subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2  11.9    0.0036       9.2       2      74 ..      12      91 ..      11     116 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0036
  Pox_RNA_Pol_19  2 edsedivdyasedeeseyeeeeedeeees..slessdvsslkese.ykvekvss.nvee...eessskqvsekisaikkr 74
                    +d +d +dy+s+d++ +y+++e+ eee    +  +++ +  k+ e y  e ++   ++e   e++++ ++ +k+ + kk+
      EFC35841.1 12 DDDDDDDDYYSDDDDGDYTDDEDGEEELYnsGDRTEKEEFEKRMEmYMKEMLEEeGIDEesdESEEETKIVKKVVEPKKK 91
                    5778889************9998877654333333333333333324435555444444333556666788888877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1630  (0.0909142); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.42
# Mc/sec: 1944.99
//
Query:       EFC35842.1  [L=125]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (125 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       560  (0.0312343); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.37u 0.26s 00:00:00.63 Elapsed: 00:00:00.40
# Mc/sec: 940.41
//
Query:       EFC35843.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      0.002   16.9   3.8     0.0033   16.2   3.8    1.3  1  efThoc1       THO complex subunit 1 transcription elongation 
  ------ inclusion threshold ------
      0.041   13.9   1.5        1.5    8.8   0.1    3.0  3  Mistic        Membrane-integrating protein Mistic
       0.11   12.7   2.3        6.2    7.1   0.3    2.9  2  FANCI_S2      FANCI solenoid 2
       0.13   12.4   2.5         10    6.4   0.1    3.3  3  T3SchapCesA   Type III secretion system filament chaperone Ce
       0.18   12.0   0.9       0.52   10.6   0.9    1.7  1  Glutaredoxin  Glutaredoxin


Domain annotation for each model (and alignments):
>> efThoc1  THO complex subunit 1 transcription elongation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   3.8   9.3e-07    0.0033     333     424 ..     279     381 ..     274     394 .] 0.77

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 9.3e-07
     efThoc1 333 kwKnegcpefekp......avseeelseapekaekfkk.........krlrgfikmGnkeltrlwkietglealkkkerntlpslesylekikleekde 416
                 k K + c++++k+      ++s +e ++a++                  +r++ik+G+++  +l ki t+lea k    + + +l++y+e ++  ++ +
  EFC35843.1 279 KCKCDHCKSVKKFlksndmEFSFKEKKDART------HvetilngidDIKRETIKHGSPQTLKLTKIRTTLEAKKAIVTSAETVLKQYIEYATKSDQKP 371
                 56899********544444333333334444......3455666999999*************************999**************9899999 PP

     efThoc1 417 eaekeee..e 424
                 +a   +e  +
  EFC35843.1 372 QARPASEsvS 381
                 8888877552 PP

>> Mistic  Membrane-integrating protein Mistic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.032   1.2e+02      16      33 ..      50      67 ..      45      79 .. 0.77
   2 ?    8.8   0.1   0.00042       1.5      38      68 ..     105     135 ..      97     140 .. 0.89
   3 ?   -2.7   0.0       1.7   6.1e+03      40      57 ..     206     221 ..     196     224 .. 0.67

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.032
                HHHHHHH--SSS-SS-SS CS
      Mistic 16 ldafieLYNeseedkpli 33
                +d+fi+LY +se  +   
  EFC35843.1 50 IDQFIDLYTKSEMRNTAF 67
                699******999876655 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00042
                 HHHHHHHHHHHHTSSSS-HHHHHHHHHHHHH CS
      Mistic  38 evleaiekAkekYGeevvnkKiNtivkevLs 68 
                 ++l++i    + +G +v+++ +N+iv+++L 
  EFC35843.1 105 NILQEIVTVMKHFGIQVLEECLNAIVEDMLV 135
                 678999999********************96 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.7
                 HHHHHHHHHHTSSSS-HH CS
      Mistic  40 leaiekAkekYGeevvnk 57 
                 +e+i+kAk  +G+  v+k
  EFC35843.1 206 VEKITKAK--HGHSLVQK 221
                 56666665..66666655 PP

>> FANCI_S2  FANCI solenoid 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.3    0.0017       6.2      37      73 ..      95     131 ..      52     135 .. 0.80
   2 ?    4.0   0.1     0.016        56      37      71 ..     152     186 ..     138     255 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0017
    FANCI_S2  37 vaqaaaklgsqiLlelfkvhesarseiieqllsriit 73 
                  +++ +++  +iL+e++ v +++  +++e++l+ i+ 
  EFC35843.1  95 LVHSKQEINLNILQEIVTVMKHFGIQVLEECLNAIVE 131
                 4566689999************************986 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.016
    FANCI_S2  37 vaqaaaklgsqiLlelfkvhesarseiieqllsri 71 
                 ++ +a+ ++s+iL++++++++ ++++  e++ + +
  EFC35843.1 152 ESDEAKHFASKILSSIIRKFDNTSEDPSEECAQLL 186
                 56678888888888888886666655555554433 PP

>> T3SchapCesA  Type III secretion system filament chaperone CesA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.017        61      40      80 ..      36      76 ..      26      88 .. 0.78
   2 ?   -0.9   0.0      0.52   1.9e+03      16      58 ..     105     148 ..      94     181 .. 0.57
   3 ?    6.4   0.1    0.0028        10      12      52 ..     334     374 ..     324     384 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.017
  T3SchapCesA 40 ilsekaktdpqaaeklnkliegytygeerkl.ydsalskiek 80
                 ils k k  p ++ k++++i+ yt  e r+  + s  ski+ 
   EFC35843.1 36 ILSFKEK-YPTCSAKIDQFIDLYTKSEMRNTaFSSEESKINA 76
                 5666666.5888999************997527888899974 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.52
  T3SchapCesA  16 kirseieaikkiiaefdvvkesvnilsekaktdp..qaaeklnkl 58 
                  +i  ei ++ k    ++v+ e +n + e     p  q  e   +l
   EFC35843.1 105 NILQEIVTVMKHF-GIQVLEECLNAIVEDMLVYPlrQRIEAYTRL 148
                  5555666665554.3567777777777766655533344444444 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0028
  T3SchapCesA  12 lldkkirseieaikkiiaefdvvkesvnilsekaktdpqaa 52 
                  l   kir+ +ea k i++  + v ++  + + k+  +pqa 
   EFC35843.1 334 LKLTKIRTTLEAKKAIVTSAETVLKQYIEYATKSDQKPQAR 374
                  55579**************9999889999999******985 PP

>> Glutaredoxin  Glutaredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.9   0.00014      0.52       8      27 ..     281     300 ..     276     307 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00014
                   SSHHHHHHHHHHHHTTGGEE CS
  Glutaredoxin   8 tCpyCkkakrlLkelgvkfe 27 
                    C +Ck +k++Lk++ ++f 
    EFC35843.1 281 KCDHCKSVKKFLKSNDMEFS 300
                   7***************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1194  (0.066596); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2531.14
//
Query:       EFC35844.1  [L=731]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.9e-16   59.5 129.8    4.2e-06   27.0   9.8    9.8  9  EGF_2         EGF-like domain
    1.2e-08   34.5   3.1    0.00019   21.3   0.0    5.4  6  NHL           NHL repeat
    4.7e-06   26.8  95.8     0.0055   17.0   7.9    9.2  9  EGF           EGF-like domain
     0.0006   19.5   0.3     0.0018   17.9   0.2    1.8  2  SGL           SMP-30/Gluconolactonase/LRE-like region
     0.0028   18.2   8.6     0.0028   18.2   8.6   11.1 11  hEGF          Human growth factor-like EGF
     0.0049   16.9   3.6     0.0049   16.9   3.6    8.0  9  EGF_Tenascin  Tenascin EGF domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   9.8   1.4e-09   4.2e-06       3      30 ..     281     305 ..     278     306 .. 0.89
   2 ?    2.5   2.6     0.066     2e+02      20      32 .]     329     341 ..     323     341 .. 0.77
   3 !   15.3   7.7   6.7e-06      0.02       6      30 ..     355     378 ..     350     381 .. 0.84
   4 ?    2.5   2.6     0.066     2e+02      20      32 .]     402     414 ..     396     414 .. 0.77
   5 !   18.2   4.8   8.3e-07    0.0025       5      30 ..     427     451 ..     423     452 .. 0.83
   6 ?    1.7   5.7      0.11   3.4e+02      10      32 .]     465     486 ..     454     486 .. 0.72
   7 !   20.6   5.6   1.4e-07   0.00043       6      30 ..     500     523 ..     495     524 .. 0.84
   8 !    9.3  17.7   0.00049       1.5       6      32 .]     535     560 ..     531     560 .. 0.84
   9 !   12.0  10.2   6.9e-05       0.2       7      30 ..     573     595 ..     565     596 .. 0.83

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 1.4e-09
       EGF_2   3 asdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 + +++C++hG+Cv  +G+C+Cdsg+ G+
  EFC35844.1 281 D-KNTCNNHGSCV--NGKCVCDSGWRGN 305
                 4.689********..**********996 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.066
       EGF_2  20 qCdCdsgyqGktC 32 
                 q +C++g++G +C
  EFC35844.1 329 QFSCQDGWTGLNC 341
                 558*******999 PP

  == domain 3  score: 15.3 bits;  conditional E-value: 6.7e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 + C+ hG+C++ +  C C sg+ G+
  EFC35844.1 355 TVCSSHGQCISNN-TCNCVSGWRGN 378
                 67*******9555.9********97 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.066
       EGF_2  20 qCdCdsgyqGktC 32 
                 q +C++g++G +C
  EFC35844.1 402 QFSCQDGWTGLNC 414
                 558*******999 PP

  == domain 5  score: 18.2 bits;  conditional E-value: 8.3e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGk 30 
                  + C+ hG+C++ +  C C sg+ G+
  EFC35844.1 427 TTVCSSHGKCISNN-TCNCVSGWRGN 451
                 568*******9555.9*******997 PP

  == domain 6  score: 1.7 bits;  conditional E-value: 0.11
       EGF_2  10 ghGtCvnqcGqCdCdsgyqGktC 32 
                  +++C+ ++   +C++g+ G+ C
  EFC35844.1 465 HGEYCIGPN-TYKCQDGWIGDLC 486
                 367899777.569*********9 PP

  == domain 7  score: 20.6 bits;  conditional E-value: 1.4e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                   C+ hG+C++ +  C C+sg+ G+
  EFC35844.1 500 AVCNSHGQCISNN-TCNCFSGWRGN 523
                 46*******9555.9********97 PP

  == domain 8  score: 9.3 bits;  conditional E-value: 0.00049
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ hG+C++ +  C+C++gy G+ C
  EFC35844.1 535 NNCQPHGQCISNN-TCKCSTGYGGNGC 560
                 68*******9555.9***********9 PP

  == domain 9  score: 12.0 bits;  conditional E-value: 6.9e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGk 30 
                  C+++G+C n+  +C+C++ y+G 
  EFC35844.1 573 GCSNNGYCSNTD-KCSCFPLYFGQ 595
                 4*******8777.*********96 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       2.1   6.3e+03      10      17 ..      54      61 ..      52      62 .. 0.69
   2 ?   -1.0   0.0      0.76   2.3e+03       2      21 ..      95     115 ..      94     119 .. 0.81
   3 !    7.2   0.0    0.0019       5.5       2      19 ..     149     166 ..     149     175 .. 0.83
   4 !   21.3   0.0   6.3e-08   0.00019       1      24 [.     203     226 ..     203     229 .. 0.89
   5 ?    1.0   0.0      0.18   5.3e+02       4      16 ..     249     261 ..     246     261 .. 0.83
   6 ?   -1.7   0.1       1.2   3.6e+03       2      11 ..     537     546 ..     536     547 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.1
                ETTTEEEE CS
         NHL 10 dsnGdiyV 17
                +s+G+++V
  EFC35844.1 54 VSDGNLCV 61
                37888887 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.76
                 SSEEEEEEE.TTTEEEEEECC CS
         NHL   2 nyPhGvavd.snGdiyVaDse 21 
                 + P+   +d +++ +y+ Ds 
  EFC35844.1  95 YGPTNMYYDaTTDFLYILDSS 115
                 6788888999999******86 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.0019
                 SSEEEEEEETTTEEEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaD 19 
                 n P+G+ +++nGd+y+a 
  EFC35844.1 149 NGPNGIMYTPNGDLYIAS 166
                 68**************95 PP

  == domain 4  score: 21.3 bits;  conditional E-value: 6.3e-08
                 BSSEEEEEEETTTEEEEEECCCTE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhr 24 
                 +nyP++v+v+s+G++y+aD +n  
  EFC35844.1 203 LNYPADVTVSSTGEVYIADWGNRA 226
                 79*****************99955 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.18
                 EEEEEEETTTEEE CS
         NHL   4 PhGvavdsnGdiy 16 
                  +Gv++++nGd++
  EFC35844.1 249 LNGVTLTPNGDLL 261
                 58********985 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 1.2
                 SSEEEEEEET CS
         NHL   2 nyPhGvavds 11 
                 ++PhG ++++
  EFC35844.1 537 CQPHGQCISN 546
                 9****88754 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   7.9   1.8e-06    0.0055       3      31 ..     282     305 ..     279     306 .. 0.91
   2 ?   -0.3   0.0      0.46   1.4e+03      24      31 ..     332     339 ..     331     340 .. 0.86
   3 !    9.5   6.5   0.00041       1.2       5      31 ..     355     378 ..     346     379 .. 0.86
   4 ?   -0.3   0.0      0.46   1.4e+03      24      31 ..     405     412 ..     404     413 .. 0.86
   5 !   11.0   6.9   0.00014       0.4       5      31 ..     426     451 ..     419     452 .. 0.86
   6 ?   -0.9   0.4      0.74   2.2e+03      18      25 ..     473     478 ..     464     484 .. 0.60
   7 !   11.4   5.2    0.0001       0.3       4      31 ..     498     523 ..     495     524 .. 0.91
   8 ?    4.5  13.6     0.015        44       1      31 [.     531     558 ..     531     559 .. 0.91
   9 !    9.4   5.0   0.00043       1.3       5      30 ..     573     594 ..     568     596 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.8e-06
                 STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 +n+C+n+G Cv+++     C C++G+ G+
  EFC35844.1 282 KNTCNNHGSCVNGK-----CVCDSGWRGN 305
                 588***********.....********97 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.46
                 ECTTEEST CS
         EGF  24 CpeGytGk 31 
                 C+ G+tG 
  EFC35844.1 332 CQDGWTGL 339
                 ******96 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00041
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + Cs +G C+++     tC C +G+ G+
  EFC35844.1 355 TvCSSHGQCISNN----TCNCVSGWRGN 378
                 37*******9999....*********97 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.46
                 ECTTEEST CS
         EGF  24 CpeGytGk 31 
                 C+ G+tG 
  EFC35844.1 405 CQDGWTGL 412
                 ******96 PP

  == domain 5  score: 11.0 bits;  conditional E-value: 0.00014
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                 +   Cs +G+C+++     tC C +G+ G+
  EFC35844.1 426 TttvCSSHGKCISNN----TCNCVSGWRGN 451
                 3458*******9999....*********97 PP

  == domain 6  score: -0.9 bits;  conditional E-value: 0.74
                 TEEEEEEC CS
         EGF  18 ggytCiCp 25 
                 ++y+C  +
  EFC35844.1 473 NTYKC--Q 478
                 55655..4 PP

  == domain 7  score: 11.4 bits;  conditional E-value: 0.0001
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 np  C+ +G C+++     tC C +G+ G+
  EFC35844.1 498 NPavCNSHGQCISNN----TCNCFSGWRGN 523
                 7799*******9999....*********97 PP

  == domain 8  score: 4.5 bits;  conditional E-value: 0.015
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  n+C+ +G C+++     tC+C++Gy G+
  EFC35844.1 531 CDGvNNCQPHGQCISNN----TCKCSTGYGGN 558
                 777799*******9999....********997 PP

  == domain 9  score: 9.4 bits;  conditional E-value: 0.00043
                 TSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 pCsngGtCvdtgrggytCiCpeGytG 30 
                  Csn+G C    +++ +C C + y+G
  EFC35844.1 573 GCSNNGYC----SNTDKCSCFPLYFG 594
                 5*******....5777******9999 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.2   6.1e-07    0.0018     131     220 ..     146     240 ..     140     245 .. 0.92
   2 ?   -2.6   0.0       1.1   3.3e+03     132     151 ..     245     264 ..     241     269 .. 0.83

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 6.1e-07
         SGL 131 ddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklieei 220
                 d+++ pNG++ +p g+ lY+a   ++ki++y+ ++ ++  +n    + ++ g+      ++p  ++v ++G+v++A wg+  v+++  +G++i+ i
  EFC35844.1 146 DGINGPNGIMYTPNGD-LYIASQGNNKIMKYSNSQLSTVAGNGYAGYSGDGGParnaklNYPADVTVSSTGEVYIADWGNRAVRKVFRNGTIITLI 240
                 89999********997.7889999**********999989999988999999999999988999**************************999865 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.1
         SGL 132 dltipNGlawspdgktlYla 151
                 +l+  NG+ ++p g+ lY +
  EFC35844.1 245 GLSELNGVTLTPNGDLLYST 264
                 56668***********9976 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       3.9   1.2e+04       5       9 ..     277     281 ..     274     283 .. 0.74
   2 !   18.2   8.6   9.3e-07    0.0028       1      22 []     285     302 ..     285     302 .. 0.97
   3 ?    0.2   0.7      0.47   1.4e+03       6      11 ..     331     336 ..     320     342 .. 0.56
   4 !    8.6   7.0     0.001       3.1       1      22 []     357     375 ..     357     375 .. 0.89
   5 ?    0.2   0.7      0.47   1.4e+03       6      11 ..     404     409 ..     393     415 .. 0.56
   6 !    8.9   6.2   0.00082       2.4       1      22 []     430     448 ..     430     448 .. 0.89
   7 ?    4.6   0.5     0.019        56       3      17 ..     465     478 ..     463     478 .. 0.82
   8 ?    1.9   8.9      0.13   3.9e+02       1      22 []     502     520 ..     502     520 .. 0.84
   9 ?   -3.2   0.7       5.2   1.6e+04       4      17 ..     523     532 ..     522     532 .. 0.69
  10 !    8.8   7.2   0.00088       2.6       1      22 []     537     555 ..     537     555 .. 0.90
  11 ?    1.7   8.7      0.15   4.6e+02       1      18 [.     574     588 ..     574     588 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3.9
                 -EES. CS
        hEGF   5 GtCid 9  
                 G+Cid
  EFC35844.1 277 GSCID 281
                 79996 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 9.3e-07
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cnn+G+C+   +g kC+C++G+
  EFC35844.1 285 CNNHGSCV---NG-KCVCDSGW 302
                 ********...88.******** PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.47
                 EES..- CS
        hEGF   6 tCidgv 11 
                 +C+dg 
  EFC35844.1 331 SCQDGW 336
                 355555 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.001
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+ +G+Ci    +++C C +G+
  EFC35844.1 357 CSSHGQCI---SNNTCNCVSGW 375
                 9999****...446******** PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.47
                 EES..- CS
        hEGF   6 tCidgv 11 
                 +C+dg 
  EFC35844.1 404 SCQDGW 409
                 355555 PP

  == domain 6  score: 8.9 bits;  conditional E-value: 0.00082
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+ +G Ci    +++C C +G+
  EFC35844.1 430 CSSHGKCI---SNNTCNCVSGW 448
                 9999****...446******** PP

  == domain 7  score: 4.6 bits;  conditional E-value: 0.019
                 TT-EES..-SS.-EE CS
        hEGF   3 ngGtCidgvggykCi 17 
                 +g  Ci g++ ykC+
  EFC35844.1 465 HGEYCI-GPNTYKCQ 478
                 4448**.99*****7 PP

  == domain 8  score: 1.9 bits;  conditional E-value: 0.13
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn +G+Ci    +++C C +G+
  EFC35844.1 502 CNSHGQCI---SNNTCNCFSGW 520
                 9*******...446****7777 PP

  == domain 9  score: -3.2 bits;  conditional E-value: 5.2
                 T-EES..-SS.-EE CS
        hEGF   4 gGtCidgvggykCi 17 
                 + +C+     ++C+
  EFC35844.1 523 NSICT----QFTCD 532
                 44898....78885 PP

  == domain 10  score: 8.8 bits;  conditional E-value: 0.00088
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G+Ci    +++C C  Gy
  EFC35844.1 537 CQPHGQCI---SNNTCKCSTGY 555
                 ********...446*****999 PP

  == domain 11  score: 1.7 bits;  conditional E-value: 0.15
                 --TT-EES..-SS.-EE- CS
        hEGF   1 CnngGtCidgvggykCiC 18 
                 C+n+G C    +  kC C
  EFC35844.1 574 CSNNGYCS---NTDKCSC 588
                 ********...778***9 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       4.2   1.3e+04       5      18 ..      67      80 ..      66      81 .. 0.81
   2 !   16.9   3.6   1.6e-06    0.0049       6      25 ..     285     304 ..     283     308 .. 0.90
   3 ?   -3.6   0.7       4.2   1.3e+04      16      27 ..     323     334 ..     322     335 .. 0.77
   4 ?    0.7   8.1       0.2   5.9e+02       6      29 .]     357     382 ..     355     382 .. 0.86
   5 ?   -3.6   0.7       4.2   1.3e+04      16      27 ..     396     407 ..     395     408 .. 0.77
   6 ?    1.3   7.3      0.12   3.6e+02       6      29 .]     430     455 ..     428     455 .. 0.86
   7 ?    0.8   2.3      0.18   5.3e+02       5      25 ..     501     522 ..     498     526 .. 0.70
   8 ?   -0.2   3.7      0.37   1.1e+03       6      28 ..     537     560 ..     535     561 .. 0.76
   9 ?    1.7   1.3     0.096   2.9e+02       5      25 ..     573     594 ..     571     598 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.2
  EGF_Tenascin  5 GCssRGvCvDGqCi 18
                  G  sR v   G C+
    EFC35844.1 67 GNQSRVVAGTGECL 80
                  66799999999995 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 1.6e-06
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsG 25 
                   C   G Cv+G+C+CDs + G
    EFC35844.1 285 CNNHGSCVNGKCVCDSGWRG 304
                   9999************9887 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 4.2
  EGF_Tenascin  16 qCiCDsEYsGDD 27 
                   qCi    +s  D
    EFC35844.1 323 QCIGPNQFSCQD 334
                   999888888766 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.2
  EGF_Tenascin   6 CssRGvCvD.GqCiCDsEYsGD.DCs 29 
                   Css G C+    C C s + G+ DCs
    EFC35844.1 357 CSSHGQCISnNTCNCVSGWRGNsDCS 382
                   *******96267*******9966998 PP

  == domain 5  score: -3.6 bits;  conditional E-value: 4.2
  EGF_Tenascin  16 qCiCDsEYsGDD 27 
                   qCi    +s  D
    EFC35844.1 396 QCIGPNQFSCQD 407
                   999888888766 PP

  == domain 6  score: 1.3 bits;  conditional E-value: 0.12
  EGF_Tenascin   6 CssRGvCvD.GqCiCDsEYsGD.DCs 29 
                   Css G C+    C C s + G+ DCs
    EFC35844.1 430 CSSHGKCISnNTCNCVSGWRGNsDCS 455
                   *******96267*******9966998 PP

  == domain 7  score: 0.8 bits;  conditional E-value: 0.18
  EGF_Tenascin   5 GCssRGvCvD.GqCiCDsEYsG 25 
                    C s G C+    C C s + G
    EFC35844.1 501 VCNSHGQCISnNTCNCFSGWRG 522
                   6889999885146888777666 PP

  == domain 8  score: -0.2 bits;  conditional E-value: 0.37
  EGF_Tenascin   6 CssRGvCvD.GqCiCDsEYsGDDC 28 
                   C   G C+    C C   Y G+ C
    EFC35844.1 537 CQPHGQCISnNTCKCSTGYGGNGC 560
                   666778875156999999*99999 PP

  == domain 9  score: 1.7 bits;  conditional E-value: 0.096
  EGF_Tenascin   5 GCssRGvCvDG.qCiCDsEYsG 25 
                   GCs  G C +  +C C   Y G
    EFC35844.1 573 GCSNNGYCSNTdKCSCFPLYFG 594
                   9*******87536888666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (731 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       626  (0.0349155); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.82u 0.36s 00:00:01.18 Elapsed: 00:00:00.57
# Mc/sec: 3838.23
//
Query:       EFC35845.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.1   0.0       0.28   11.0   0.0    1.6  1  RVP_2     Retroviral aspartyl protease


Domain annotation for each model (and alignments):
>> RVP_2  Retroviral aspartyl protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   1.6e-05      0.28      78     129 ..     164     215 ..     160     222 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.6e-05
       RVP_2  78 keicksveieiqgiefladlilLdlkdlDviLgmdWLsknkanidcaekkvt 129
                 + + k++++ i++++f  d  lL  + +D i+ md  ++   + d a kk++
  EFC35845.1 164 HLVGKKLTVCIASWSFFWDWNLLSESRVDKIITMDTYAARAEQFDSAFKKAV 215
                 5678999*****************************9999999998766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       485  (0.0270511); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1773.71
//
Query:       EFC35846.1  [L=119]
Description: rho family small GTPase, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-40  137.1   0.0    4.3e-40  137.0   0.0    1.0  1  Ras       Ras family
      2e-22   79.6   0.0    2.3e-22   79.5   0.0    1.0  1  Roc       Ras of Complex, Roc, domain of DAPkinase
    2.4e-07   30.3   0.0    2.6e-07   30.2   0.0    1.1  1  Arf       ADP-ribosylation factor family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.0   0.0   7.1e-44   4.3e-40       1     110 [.       8     116 ..       8     119 .] 0.97

  Alignments for each domain:
  == domain 1  score: 137.0 bits;  conditional E-value: 7.1e-44
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 K+v vGd+avGKt+ll+ ++k++F++ey +T+ +d+y++ +e+++kev++ +wDTAGqe++++lr+l+y ++++++++y++t+++s+env+ kw+ e++
  EFC35846.1   8 KIVTVGDGAVGKTCLLYAYAKNEFPQEYVPTV-FDNYNTMVEINDKEVSIGLWDTAGQEDYDKLRPLSYPGTNCFIVCYAVTNQASYENVEaKWYPELQ 105
                 89******************************.****************************************************************** PP

                 HHSTTTSEEEEE CS
         Ras  99 rvaeenvpivLv 110
                 + ++ + pi+L 
  EFC35846.1 106 KNCP-DAPIILW 116
                 ****.5999985 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5   0.0   3.8e-26   2.3e-22       1     113 [.       8     115 ..       8     119 .] 0.87

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 3.8e-26
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K+v vGd++vGKt+ll  + +++f +++ +t+  ++ t  +++i+        k+v++ +WDtaGqe++++l+pl + + +++i++y    + s+en++
  EFC35846.1   8 KIVTVGDGAVGKTCLLYAYAKNEFPQEYVPTVFDNYNT--MVEIND-------KEVSIGLWDTAGQEDYDKLRPLSYPGTNCFIVCYAvtnQASYENVE 97 
                 9*******************************988865..334433.......5799****************************99854344567885 PP

                 .HHHHHHHHHCSSS-EEE CS
         Roc  97 .eWlkelkkvagkspvil 113
                  +W+ el+k+++++p+il
  EFC35846.1  98 aKWYPELQKNCPDAPIIL 115
                 38**************98 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.2   0.0   4.4e-11   2.6e-07      14      91 ..       6      87 ..       1     107 [. 0.80

  Alignments for each domain:
  == domain 1  score: 30.2 bits;  conditional E-value: 4.4e-11
                EEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEEEEE...TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEET CS
         Arf 14 elrilllGLDnaGKtTilkklkleelvt.tvPTigfnveelei...knlkftvwDvGGqeklRplWknYfektdavifvvDs 91
                 l+i+ +G  + GKt +l+ + ++e+ +  vPT+  n +++     k++++ +wD  Gqe   +l    ++ t+  i +  +
  EFC35846.1  6 ILKIVTVGDGAVGKTCLLYAYAKNEFPQeYVPTVFDNYNTMVEindKEVSIGLWDTAGQEDYDKLRPLSYPGTNCFIVCYAV 87
                579*****9999************9966499***99887643224499***********98888877788888887776555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       461  (0.0257125); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 806.45
//
Query:       EFC35847.1  [L=278]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.6e-82  276.2   0.3      3e-82  276.0   0.3    1.0  1  ATP_bind_1  Conserved hypothetical ATP binding protein
  ------ inclusion threshold ------
       0.02   15.4   0.6      0.087   13.4   0.1    2.3  2  AAA_18      AAA domain
      0.061   13.6   0.1       0.23   11.7   0.0    2.0  2  AAA_22      AAA domain
      0.076   12.5   0.0        0.9    9.0   0.0    2.1  2  AAA_7       P-loop containing dynein motor region
      0.076   12.8   0.0          1    9.1   0.0    2.6  3  CLP1_P      mRNA cleavage and polyadenylation factor CLP1 P-l
      0.086   12.8   0.0       0.44   10.5   0.0    1.9  2  gpD         Bacteriophage scaffolding protein D
       0.09   12.5   0.0       0.16   11.8   0.0    1.4  1  AAA_29      P-loop containing region of AAA domain


Domain annotation for each model (and alignments):
>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  276.0   0.3   1.2e-85     3e-82       1     241 []       8     258 ..       8     258 .. 0.92

  Alignments for each domain:
  == domain 1  score: 276.0 bits;  conditional E-value: 1.2e-85
  ATP_bind_1   1 vvGpaGsGKttfvgalseilelrgrsvavvNLDPAaeelpYeaavdirelitledvmedlglgpngalvvaleflresl.dwldeelekeeddyllfDt 98 
                 v+GpaGsGK+t+++ ++e+ ++++r ++vvNLDPAaee++Y++a dir+l+tledvme+ +lgpng+lv+++e+l+++l dw++eel+++e+dyl+fD+
  EFC35847.1   8 VIGPAGSGKSTYCQ-IQEHGNNTKRIIHVVNLDPAAEEFKYQCAFDIRDLVTLEDVMEEFQLGPNGGLVYCMEYLMQNLeDWFSEELSDYENDYLIFDC 105
                 8************7.89********************************************************************************** PP

  ATP_bind_1  99 PGQielfthseslakiveeLes.efalvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek..lekeleffedvealslllekee 194
                 PGQiel+ h++ ++ +v+eLe+  +++++vy++D+q+++d+tk+isg+ +alsam++ e+Phv++++k+D lk +  +   le ++ +++ +ll  +e+
  EFC35847.1 106 PGQIELYSHVPIMQLFVKELERrGYRVCCVYCMDVQFIEDVTKYISGITQALSAMIQFETPHVNIFTKCDTLKGNkeRSNILEKLKVPDKTELLYALEK 204
                 **********************9**************************************************88764444555444444443333333 PP

  ATP_bind_1 195 ........ekykklaeaiaelleefalvlrflplssekeesiedllslidealqe 241
                         + ++kl+ ai++l+++f++v  fl l+  +eesie++ls++d ++q+
  EFC35847.1 205 etnphkrnSSFSKLNHAIVSLIDNFNMV-GFLELDITDEESIEYILSYVDMTIQY 258
                 337***9999******************.*********************99986 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   3.4e-05     0.087       2      70 ..       7      93 ..       7     139 .. 0.62
   2 ?   -1.2   0.0       1.1   2.7e+03      11      62 ..     195     250 ..     194     269 .. 0.67

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.4e-05
      AAA_18  2 lltGtpGvGKttlakeLskrlgf.....................gvnlrdvakenglllevdpealdeskrldedkldklldaleenss..a 70
                l+ G++G+GK+t ++  ++++++                      + +rd+++ ++  +e++     ++  l+   +++l+++le + s   
  EFC35847.1  7 LVIGPAGSGKSTYCQI-QEHGNNtkriihvvnldpaaeefkyqcAFDIRDLVTLEDVMEEFQLG---PNGGLVY-CMEYLMQNLEDWFSeeL 93
                589***********95.68865568888766666666655555555555555555555555444...2222222.22455555555555542 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.1
      AAA_18  11 KttlakeLskrlgf.gvnlrdvakenglllevdpe...aldeskrldedkldklld 62 
                 Kt+l  +L+k+++   +n+++   ++ ++   d++    + e ++ de+  +++l+
  EFC35847.1 195 KTELLYALEKETNPhKRNSSFSKLNHAIVSLIDNFnmvGFLELDITDEESIEYILS 250
                 77888888777633677777777777777777777666666666666666666555 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   9.1e-05      0.23       9      30 ..       7      28 ..       2     104 .. 0.66
   2 ?   -1.4   0.0         1   2.6e+03      60      88 ..     186     208 ..     162     258 .. 0.54

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 9.1e-05
      AAA_22  9 vvtGesGtGKTtllrrlleqld 30
                +v+G++G+GK+t ++   + ++
  EFC35847.1  7 LVIGPAGSGKSTYCQIQEHGNN 28
                79************98777764 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1
      AAA_22  60 llralglelka..........erlsseellealeqalra 88 
                 +l++l+++ k+          +                 
  EFC35847.1 186 ILEKLKVPDKTellyaleketN----------------P 208
                 5555555444433322222221................2 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.0   0.00035       0.9      33      68 ..       3      37 ..       1      52 [. 0.73
   2 ?    1.2   0.0     0.087   2.2e+02      82     136 ..     202     258 ..     188     268 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00035
       AAA_7 33 kkpvllvGptGtGKtviikdllkkldkekylsltin 68
                k+  l++Gp+G+GK+++++   +  + +k +++++n
  EFC35847.1  3 KHAQLVIGPAGSGKSTYCQIQEHGNN-TKRIIHVVN 37
                56789************986555444.555555555 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.087
       AAA_7  82 iesklekrrkgvygPpggkklvvFvDDlnmpake..kygaqppiellRqlldyggwY 136
                 +e++ + ++++    + ++ +v  +D++nm      +  + + ie +  ++d+   Y
  EFC35847.1 202 LEKETNPHKRNSSFSKLNHAIVSLIDNFNMVGFLelDITDEESIEYILSYVDMTIQY 258
                 56666666666777788999999*******743201234455566665666655555 PP

>> CLP1_P  mRNA cleavage and polyadenylation factor CLP1 P-loop
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.0    0.0004         1       1      40 [.      10      48 ..      10      67 .. 0.86
   2 ?   -0.4   0.0      0.32   8.3e+02      84     115 ..      78     110 ..      73     122 .. 0.71
   3 ?   -1.4   0.0      0.69   1.8e+03      23      48 ..     230     254 ..     212     269 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0004
      CLP1_P  1 GpkdsGKSTlarlLlNyalrkgrkpv.yvDlDvGqseispP 40
                Gp  sGKST++++      +++++++ +v+lD+   e+ + 
  EFC35847.1 10 GPAGSGKSTYCQIQEH--GNNTKRIIhVVNLDPAAEEFKYQ 48
                899*********8654..478888888******99998765 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.32
      CLP1_P  84 vkelareveek.leenkkakasgliIntpGwvk 115
                 ++ l++++e   +ee ++++++ li ++pG ++
  EFC35847.1  78 MEYLMQNLEDWfSEELSDYENDYLIFDCPGQIE 110
                 555555555542345567899*********987 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.69
      CLP1_P  23 rkpvyvDlDvGqseispPgtislalv 48 
                 + + +++lD+ + e s+ +++s + +
  EFC35847.1 230 NMVGFLELDITDEE-SIEYILSYVDM 254
                 44559999999888.88888886654 PP

>> gpD  Bacteriophage scaffolding protein D
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.42   1.1e+03      91     121 ..      18      47 ..      14      66 .. 0.70
   2 ?   10.5   0.0   0.00017      0.44      56     121 ..     134     202 ..     121     210 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.42
                 HHHHHHTTSBSHHHHHCTCEEBB-HHHHHHH CS
         gpD  91 taclimegaefteniingverpvkaaelfaf 121
                 t c i e  + t+ ii  v+    aae f +
  EFC35847.1  18 TYCQIQEHGNNTKRIIHVVNLDP-AAEEFKY 47 
                 78999999999999999988654.4454443 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00017
                 HHHHH.HHHTT.--SSSBB.HHHHHHHHHHHS-HHHHHHHHHHHTTSBSHHHHHCTCEEBB-HHHHHHH CS
         gpD  56 cvygt.ldfvg.yprfpap.vefiaaviayyvhpvniqtaclimegaefteniingverpvkaaelfaf 121
                 cvy   ++f+    ++ +   + ++a+i +    vni t c  ++g +   ni++ ++ p k+  l+a+
  EFC35847.1 134 CVYCMdVQFIEdVTKYISGiTQALSAMIQFETPHVNIFTKCDTLKGNKERSNILEKLKVPDKTELLYAL 202
                 555432455541344444414678999***999*****************************9999986 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   6.1e-05      0.16      24      37 ..       5      18 ..       1      20 [. 0.86

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 6.1e-05
      AAA_29 24 atlltGpsGsGKST 37
                a l++Gp GsGKST
  EFC35847.1  5 AQLVIGPAGSGKST 18
                579**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (278 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       662  (0.0369234); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1777.27
//
Query:       EFC35848.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      6e-70  234.9   0.1    7.8e-70  234.5   0.1    1.1  1  ATP-grasp_2   ATP-grasp domain
    3.7e-10   39.7   0.1    5.5e-10   39.1   0.1    1.3  1  ATP-grasp_5   ATP-grasp domain
  ------ inclusion threshold ------
      0.042   13.6   0.0       0.18   11.5   0.0    1.9  1  GARS_A        Phosphoribosylglycinamide synthetase, ATP-grasp
      0.053   12.9   0.1       0.45    9.9   0.0    2.2  2  Endonuc-MspI  Restriction endonuclease MspI
      0.088   12.6   0.1       0.18   11.6   0.1    1.6  1  Ligase_CoA    CoA-ligase


Domain annotation for each model (and alignments):
>> ATP-grasp_2  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  234.5   0.1   2.2e-73   7.8e-70       1     201 [.      31     239 ..      31     240 .. 0.99

  Alignments for each domain:
  == domain 1  score: 234.5 bits;  conditional E-value: 2.2e-73
                  BE-HHHHHHHHHCTT----SEEEESSHHHHHHHHHHHTSS.SEEEEE--SSSTCCCT.......TCEEEESSHHHHHHHHHCCTTSEEE-TTS-TT-E CS
  ATP-grasp_2   1 nlhEyqakeilakygvkvpegevaesaeeaeeaakklgek.elvvKaQvlaGGRGKa.......gGvklvkskeeakeaakellgkelvtkqtgkeGk 90 
                  nlhEyqa++++++y+++vp+g+v +sa e ++a ++lg++ +++vKaQvlaGGRG++       gGv+ + s  ea+++++++lg+ lvtkqtg+eGk
   EFC35848.1  31 NLHEYQAQDLFRSYDISVPRGKVLTSATETKKACTELGNHvDYIVKAQVLAGGRGRGkfksglkGGVQKALSIGEAEDYVSKMLGQVLVTKQTGAEGK 128
                  79***********************************987359******************************************************* PP

                  EE--EEEEE---ECEEEEEEEEEETTTTEEEEEEESSTTS-HHHHHHH-GGGEEEEEEBTTTB--HHHHHHHHHHCT--CHHHHHHHHHHHHHHHHHH CS
  ATP-grasp_2  91 kvekvlveealdikkElYlsivlDraskkvvviaSseGGvdiEevaakkPekiikvaidpakglkeeqareiakklglekelvkkaakiikklyklfv 188
                  +++kv+v+e+l  ++ElYl+i+lDr+s ++v+i S++GG+ iE+va ++Pe+i+ ++i +++gl+++qa+ +a+klg+++el+++a+++i+kly+lf+
   EFC35848.1 129 PCNKVYVQERLYARRELYLAILLDRQSGGPVLIGSTQGGMAIEDVARESPEEIHTIPISVKEGLHKSQAEGLARKLGFRDELLDQAVDQITKLYNLFM 226
                  ************************************************************************************************** PP

                  HTTEEEEEEEEEE CS
  ATP-grasp_2 189 eldatlvEiNPLv 201
                  ++d  l+EiNPL+
   EFC35848.1 227 KTDSVLLEINPLI 239
                  ************8 PP

>> ATP-grasp_5  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1   0.1   1.5e-13   5.5e-10       8     222 .]      30     255 ..      23     255 .. 0.80

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 1.5e-13
  ATP-grasp_5   8 tlLteaeakelleaygipvvetrlassaeeaveaaeeigypvvlKivspdil.......hKtdv.gGvrlnlk...daeevraaaeeilervkekspe 94 
                    L e++a++l++ y+i+v++ ++ +sa+e  +a+ e+g  v   +  + +         K+ + gGv+  l+    ++ v + + ++l + ++ +++
   EFC35848.1  30 LNLHEYQAQDLFRSYDISVPRGKVLTSATETKKACTELGNHVDYIVKAQVLAggrgrgkFKSGLkGGVQKALSigeAEDYVSKMLGQVLVTKQTGAEG 127
                  5699**********************************999876555544444444433366553789887763323344555555555555666688 PP

  ATP-grasp_5  95 ariegvlVqemakrggrElivgvteDpvFGpvilfGl..GGtavevlkdvavalpplnstlareliertkaskllkgvrgekkadlaaleellvrlsq 190
                  +  ++v Vqe    + rEl + +  D + G  +l+G   GG+a+e ++  + +        ++e + + +a  l+++   +    l++ ++ +++l +
   EFC35848.1 128 KPCNKVYVQERLY-ARRELYLAILLDRQSGGPVLIGStqGGMAIEDVARESPEEIHTIPISVKEGLHKSQAEGLARKLGFR-DELLDQAVDQITKLYN 223
                  99********966.78************99888888555******999998888888889999999999999999997777.6689999999****** PP

  ATP-grasp_5 191 LvvdlpeIreldinPllveeeg.vvalDarirl 222
                  L ++   +  l+inPl+ +++g v+++Da++++
   EFC35848.1 224 LFMKTDSV-LLEINPLIETADGkVICADAKVNI 255
                  ****8887.5**********998*******987 PP

>> GARS_A  Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0     5e-05      0.18       6      53 ..      37      85 ..      34     161 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5e-05
                HHHHHHHTT--B--EEEESSHHHHHHHHHHHSSSE.EEEEESC-GGGT- CS
      GARS_A  6 akdllkkagiptaeyeaftdpeeakeyieeataka.lVvKadglaagKg 53
                a+dl++ ++i  ++ +++t++ e k+  +e+++++ ++vKa+ la+g+g
  EFC35848.1 37 AQDLFRSYDISVPRGKVLTSATETKKACTELGNHVdYIVKAQVLAGGRG 85
                6899****************************99989**********98 PP

>> Endonuc-MspI  Restriction endonuclease MspI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00013      0.45     108     141 ..      14      47 ..       7      71 .. 0.88
   2 ?    0.1   0.0      0.12   4.4e+02     108     154 ..     180     220 ..     172     230 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00013
  Endonuc-MspI 108 elkiatisvkntsaktvsvHeysaedlikvldls 141
                   +++ ++is   t+++ + +Hey+a+dl +  d+s
    EFC35848.1  14 KKNLSQISTNTTQKRLLNLHEYQAQDLFRSYDIS 47 
                   556799*********************9988775 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.12
  Endonuc-MspI 108 elkiatisvkntsaktvsvHeysaedlikvldlsdsdlrellkkfqe 154
                   e++++ isvk+       +H  +ae l++ l  +d+ l +++ ++ +
    EFC35848.1 180 EIHTIPISVKE------GLHKSQAEGLARKLGFRDELLDQAVDQITK 220
                   55555666665......468999999999999999999999988766 PP

>> Ligase_CoA  CoA-ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   5.1e-05      0.18       1      25 [.     299     323 ..     299     344 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.1e-05
                 EESSHHHHHHHHHHHHHT....... CS
  Ligase_CoA   1 lvnGGtLayeamdlikealgdvasn 25 
                 +vnG++La+++md+ik+  +d + +
  EFC35848.1 299 IVNGAGLAMATMDIIKLYGEDSMME 323
                 69**************998777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       432  (0.024095); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2189.60
//
Query:       EFC35849.1  [L=354]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.6e-32  108.4  19.0    9.1e-09   34.9   0.6    7.4  8  NHL           NHL repeat
    1.5e-08   34.2   7.7     0.0038   16.4   1.5    3.6  3  DUF5128       6-bladed beta-propeller
    9.2e-08   32.0   0.6      0.006   16.2   0.0    4.5  4  SGL           SMP-30/Gluconolactonase/LRE-like region
    2.7e-05   24.3   0.0       0.02   14.8   0.0    3.1  2  Phytase-like  Esterase-like activity of phytase
    0.00041   20.2   5.6        1.3    9.0   0.1    4.1  4  DUF4934       Domain of unknown function (DUF4934)
  ------ inclusion threshold ------
      0.014   15.8   0.3        1.4    9.5   0.0    3.0  3  PQQ_3         PQQ-like domain
       0.02   15.1   0.0        7.6    6.9   0.0    3.3  3  NUMOD1        NUMOD1 domain
      0.039   13.9   0.0          2    8.5   0.0    3.1  3  PQQ           PQQ enzyme repeat
        8.5    6.6   8.8         41    4.4   0.3    4.1  4  zf-SAP30      SAP30 zinc-finger


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.0   0.1   8.9e-12   1.8e-08       1      28 []      86     113 ..      86     113 .. 0.98
   2 ?    1.2   0.0      0.22   4.4e+02       4      18 ..     128     143 ..     126     149 .. 0.87
   3 ?   -0.9   0.0         1   2.1e+03       1       9 [.     172     180 ..     172     185 .. 0.81
   4 !   15.9   0.0     5e-06      0.01      13      28 .]     189     204 ..     188     204 .. 0.92
   5 !   23.8   0.3   1.6e-08   3.1e-05       1      28 []     228     255 ..     228     255 .. 0.98
   6 ?   -0.6   0.0      0.84   1.7e+03       2       8 ..     275     281 ..     275     286 .. 0.83
   7 ?    5.2   0.0     0.012        24      17      27 ..     294     304 ..     292     305 .. 0.90
   8 !   34.9   0.6   4.6e-12   9.1e-09       1      28 []     326     353 ..     326     353 .. 0.98

  Alignments for each domain:
  == domain 1  score: 34.0 bits;  conditional E-value: 8.9e-12
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f++P+++a+d++++i+++D+en+rvq+F
  EFC35849.1  86 FSSPTDIAIDPSDNIIICDNENNRVQIF 113
                 899************************9 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.22
                 EEEEEEE.TTTEEEEE CS
         NHL   4 PhGvavd.snGdiyVa 18 
                 P Gv+ d + G i+V+
  EFC35849.1 128 PYGVTFDaKEGVILVT 143
                 669****999*99997 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 1
                 BSSEEEEEE CS
         NHL   1 fnyPhGvav 9  
                 f+yP+G+ v
  EFC35849.1 172 FSYPTGIIV 180
                 899**9965 PP

  == domain 4  score: 15.9 bits;  conditional E-value: 5e-06
                 TEEEEEECCCTEEEEE CS
         NHL  13 GdiyVaDsenhrvqvF 28 
                 G i+V+D +nhr+q F
  EFC35849.1 189 GKIIVCDHHNHRIQMF 204
                 89***********965 PP

  == domain 5  score: 23.8 bits;  conditional E-value: 1.6e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f+ P+++ +d +G+++++D++n rvqvF
  EFC35849.1 228 FYGPNSLDIDIDGNLVITDRYNCRVQVF 255
                 899************************9 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.84
                 SSEEEEE CS
         NHL   2 nyPhGva 8  
                 ++P+G++
  EFC35849.1 275 CDPTGIC 281
                 89****9 PP

  == domain 7  score: 5.2 bits;  conditional E-value: 0.012
                 EEECCCTEEEE CS
         NHL  17 VaDsenhrvqv 27 
                 ++D+ n+r+q+
  EFC35849.1 294 ICDYANNRIQI 304
                 89********8 PP

  == domain 8  score: 34.9 bits;  conditional E-value: 4.6e-12
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f  P+Gv+++s G+++V D++nhrvq+F
  EFC35849.1 326 FDGPNGVSITSEGHLVVVDYHNHRVQIF 353
                 889************************9 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   5.8e-06     0.012      63      87 ..      98     122 ..      80     126 .. 0.83
   2 !    5.1   0.1    0.0054        11      65     113 ..     140     187 ..     132     188 .. 0.85
   3 !   16.4   1.5   1.9e-06    0.0038      63     140 ..     189     268 ..     185     316 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.8e-06
     DUF5128  63 krifvlDsaknnlfvFdkkGkfvrk 87 
                 + i++ D+ +n++ +Fdk+Gkf rk
  EFC35849.1  98 DNIIICDNENNRVQIFDKQGKFLRK 122
                 889*******************998 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0054
     DUF5128  65 ifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesI 113
                 i+v  s +  ++ Fdk+G  v k g++G   g + + + +i+ + + +I
  EFC35849.1 140 ILV-TSDDHCVYAFDKSGTEVGKFGSKGAEYGHFSYPTGIIVSETKSQI 187
                 555.344455********************************9999887 PP

  == domain 3  score: 16.4 bits;  conditional E-value: 1.9e-06
     DUF5128  63 krifvlDsaknnlfvFdkkGkfvrkIgaqGeGP...gE.YlqindfiidksnesIyildfmknkiltYdLegykfieekkld 140
                 ++i+v D  + ++  Fdk G f +  g  G  P   g  +   n+  id +  ++ i d+ + ++ ++ L+g  f+++  + 
  EFC35849.1 189 GKIIVCDHHNHRIQMFDKYGSFLKSFGTNGTNPemeGGyFYGPNSLDIDIDG-NLVITDRYNCRVQVFTLDG-TFVRKFSVK 268
                 79*******************************4442425569******666.7888*************99.998876554 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0     3e-06     0.006     186     232 ..      89     133 ..      57     145 .. 0.81
   2 ?    3.3   0.0     0.027        53     184     219 ..     173     213 ..     135     226 .. 0.57
   3 ?    4.7   0.0      0.01        20     186     229 ..     231     274 ..     216     280 .. 0.84
   4 ?    1.9   0.0     0.068   1.4e+02     183     210 ..     325     353 ..     290     354 .] 0.71

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 3e-06
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGklieeiklpakrvtscaF 232
                 p  +a+D ++n++++  ++++v+ fd++Gk +++ ++p  ++  ++F
  EFC35849.1  89 PTDIAIDPSDNIIICDNENNRVQIFDKQGKFLRKFSVP--KPYGVTF 133
                 55589*********************************..5555555 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.027
         SGL 184 gepDGlavDae.....GnvwvAvwgggkvvrfdpdGkliee 219
                 ++p G++v ++     G+++v+  ++++++ fd+ G+ ++ 
  EFC35849.1 173 SYPTGIIVSETksqipGKIIVCDHHNHRIQMFDKYGSFLKS 213
                 34555555543233337888888888888888888877665 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.01
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGklieeiklpakrvts 229
                 p +l +D +Gn+ ++   + +v++f+ dG+ +++ +++ +  + 
  EFC35849.1 231 PNSLDIDIDGNLVITDRYNCRVQVFTLDGTFVRKFSVKKQENSE 274
                 778899***************************99999555555 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.068
         SGL 183 e..gepDGlavDaeGnvwvAvwgggkvvrf 210
                 +  g p G+ +++eG++ v  +++++v+ f
  EFC35849.1 325 QfdG-PNGVSITSEGHLVVVDYHNHRVQIF 353
                 2423.8889999999999999999999876 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0     1e-05      0.02      72     112 ..      91     131 ..      27     139 .. 0.83
   2 !    6.0   0.0    0.0052        10      69     112 ..     230     273 ..     129     291 .. 0.65

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1e-05
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkllrelplpaellp 112
                   +ia++p +++++++  ++++  fd++Gk+lr++++p+ + +
    EFC35849.1  91 DIAIDPSDNIIICDNENNRVQIFDKQGKFLRKFSVPKPYGV 131
                   79**********************************99865 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0052
  Phytase-like  69 DpEgiavapdgtfwvssEggpfilefdadGkllrelplpaellp 112
                    p ++ ++ dg++++++ ++ ++  f++dG++ r+++++++ + 
    EFC35849.1 230 GPNSLDIDIDGNLVITDRYNCRVQVFTLDGTFVRKFSVKKQENS 273
                   55677888999***********************9999987654 PP

>> DUF4934  Domain of unknown function (DUF4934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.0    0.0065        13      63     101 ..      82     120 ..      74     123 .. 0.68
   2 !    5.2   0.1    0.0098        20      34      70 ..     138     174 ..     130     187 .. 0.72
   3 !    9.0   0.1   0.00065       1.3      35      68 ..     190     224 ..     176     263 .. 0.61
   4 ?    0.0   0.1       0.4     8e+02      28      82 ..     286     340 ..     276     352 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0065
     DUF4934  63 edPegysevagwlndatgllyfsrkpdklvkydakGefl 101
                 ed +  s +   ++++++++   +++++++++d++G+fl
  EFC35849.1  82 EDGQFSSPTDIAIDPSDNIIICDNENNRVQIFDKQGKFL 120
                 455555555667777777777777888888888888774 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0098
     DUF4934  34 dkivvsskkqC.llfdketGkflasvGhiGedPegyse 70 
                   i+v+s+++C ++fdk +G  + + G +G +   +s 
  EFC35849.1 138 GVILVTSDDHCvYAFDK-SGTEVGKFGSKGAEYGHFSY 174
                 56899999999457887.57778888888877665555 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00065
     DUF4934  35 kivvss..kkqCllfdketGkflasvGhiGedPegy 68 
                 ki+v    +++ ++fdk  G fl+s G  G +Pe  
  EFC35849.1 190 KIIVCDhhNHRIQMFDK-YGSFLKSFGTNGTNPEME 224
                 45555446789999998.59*************953 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.4
     DUF4934  28 kikllkdkivvsskkqCllfdketGkflasvGhiGedPegysevagwlndatgll 82 
                 +i l    i  +++++ ++++ ++G  +++ G  G +   +   +g+   ++g+l
  EFC35849.1 286 NIGLNYAAICDYANNRIQIWNLREGAIIKQFGCYGSEDGQFDGPNGVSITSEGHL 340
                 5666666777778899999999999999999999987766666666666555655 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00071       1.4      17      37 ..     131     153 ..     121     155 .. 0.74
   2 ?   -2.6   0.0       4.4   8.8e+03      30      33 ..     239     242 ..     223     260 .. 0.58
   3 ?    2.9   0.0     0.087   1.7e+02      17      31 ..     332     348 ..     305     352 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00071
       PQQ_3  17 pavd..gglvyvgtgdGtlyAlD 37 
                 +++d  +g++ v+++d+ +yA+D
  EFC35849.1 131 VTFDakEGVILVTSDDHCVYAFD 153
                 4444338***************9 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 4.4
       PQQ_3  30 dGtl 33 
                 dG+l
  EFC35849.1 239 DGNL 242
                 3333 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.087
       PQQ_3  17 p.avdgglvyvgtg.dG 31 
                 +  +++g+++v+++ ++
  EFC35849.1 332 VsITSEGHLVVVDYhNH 348
                 347899******99555 PP

>> NUMOD1  NUMOD1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.15   2.9e+02       3      17 ..     110     124 ..     109     124 .. 0.90
   2 ?    6.9   0.0    0.0038       7.6       2      19 ..     148     165 ..     148     167 .. 0.91
   3 ?    1.9   0.0      0.14   2.8e+02       3      17 ..     252     266 ..     251     270 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.15
      NUMOD1   3 VyvYDlntktigkFs 17 
                 V ++D  +k+++kFs
  EFC35849.1 110 VQIFDKQGKFLRKFS 124
                 679***********7 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0038
      NUMOD1   2 pVyvYDlntktigkFsSi 19 
                 +Vy++D +++++gkF S+
  EFC35849.1 148 CVYAFDKSGTEVGKFGSK 165
                 6**************997 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.14
      NUMOD1   3 VyvYDlntktigkFs 17 
                 V v++l++++++kFs
  EFC35849.1 252 VQVFTLDGTFVRKFS 266
                 779***********8 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.17   3.4e+02       1      26 [.      98     123 ..      98     127 .. 0.85
   2 ?    8.5   0.0     0.001         2       1      23 [.     138     159 ..     138     171 .. 0.83
   3 ?   -2.1   0.0       2.3   4.6e+03       7      26 ..     297     316 ..     293     317 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.17
                 TEEEEE.ETTSEEEEEETTTCCEEEEE CS
         PQQ   1 gvvylg.sadGylyAlDadTGkvlWrf 26 
                 ++++++   ++++  +D + Gk l +f
  EFC35849.1  98 DNIIICdNENNRVQIFD-KQGKFLRKF 123
                 689999999********.999987666 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.001
                 TEEEEEETTSEEEEEETTTCCEE CS
         PQQ   1 gvvylgsadGylyAlDadTGkvl 23 
                 gv+ ++s+d ++yA+D ++G+++
  EFC35849.1 138 GVILVTSDDHCVYAFD-KSGTEV 159
                 567788**********.999987 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 2.3
                 ETTSEEEEEETTTCCEEEEE CS
         PQQ   7 sadGylyAlDadTGkvlWrf 26 
                  a++++   +++ G ++ +f
  EFC35849.1 297 YANNRIQIWNLREGAIIKQF 316
                 67899999999999999888 PP

>> zf-SAP30  SAP30 zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.59   1.2e+03      47      61 ..      99     113 ..      91     122 .. 0.77
   2 ?    4.4   0.3     0.021        41      48      60 ..     191     203 ..     184     206 .. 0.87
   3 ?    2.7   0.1      0.07   1.4e+02      47      59 ..     291     303 ..     280     309 .. 0.82
   4 ?    1.4   0.2      0.18   3.6e+02      46      60 ..     338     352 ..     334     354 .] 0.85

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.59
    zf-SAP30  47 hiyiCdyhknliqsv 61 
                  i iCd   n +q  
  EFC35849.1  99 NIIICDNENNRVQIF 113
                 588****99999965 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.021
    zf-SAP30  48 iyiCdyhknliqs 60 
                 i +Cd+h + iq 
  EFC35849.1 191 IIVCDHHNHRIQM 203
                 789********95 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.07
    zf-SAP30  47 hiyiCdyhknliq 59 
                 +  iCdy  n iq
  EFC35849.1 291 YAAICDYANNRIQ 303
                 567********99 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.18
    zf-SAP30  46 rhiyiCdyhknliqs 60 
                  h+ + dyh + +q 
  EFC35849.1 338 GHLVVVDYHNHRVQI 352
                 5999******99995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       506  (0.0282224); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2066.69
//
Query:       EFC35850.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       443  (0.0247086); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1394.80
//
Query:       EFC35851.1  [L=513]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        4.5    7.3  10.9         24    5.0   3.7    3.3  3  cEGF      Complement Clr-like EGF-like


Domain annotation for each model (and alignments):
>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0    0.0018        32      14      22 ..      65      73 ..      59      73 .. 0.90
   2 ?   -0.0   0.3      0.05   8.9e+02      17      22 ..     107     112 ..     106     112 .. 0.86
   3 ?    5.0   3.7    0.0013        24       1      10 [.     207     217 ..     207     221 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0018
                ETTTEEEE- CS
        cEGF 14 pdGrsCtDI 22
                pdG sC+D+
  EFC35851.1 65 PDGFSCEDV 73
                8*******8 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.05
                 TEEEE- CS
        cEGF  17 rsCtDI 22 
                 r+C+D+
  EFC35851.1 107 RTCIDV 112
                 9****8 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0013
                 SEEEE-S.TTE CS
        cEGF   1 SYrCsCp.pGY 10 
                 SY+C+C  +GY
  EFC35851.1 207 SYYCTCLsNGY 217
                 9*****98888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (513 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1234  (0.068827); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 3127.39
//
Query:       EFC35852.1  [L=285]
Description: FabG domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.9e-16   58.5   0.0    2.6e-14   53.2   0.0    2.2  2  adh_short     short chain dehydrogenase
    1.6e-11   44.2   0.0    2.9e-11   43.4   0.0    1.3  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    3.5e-05   23.8   0.0    0.00012   22.1   0.0    1.7  2  KR            KR domain
     0.0015   17.7   0.0     0.0022   17.2   0.0    1.2  1  PAE           Pectinacetylesterase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.2   0.0   5.7e-18   2.6e-14       1     137 [.       4     144 ..       4     153 .. 0.83
   2 ?    3.1   0.0     0.013        57     160     188 ..     179     207 ..     171     211 .. 0.88

  Alignments for each domain:
  == domain 1  score: 53.2 bits;  conditional E-value: 5.7e-18
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGGCS CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfsels 97 
                 k +l +G++sGIGra+a ++a++ ++v +++rsee+ +e+++e+k++    k+ +i+vD + ++++e++ ++ ++++++ld  v   Gi+ ++   +++
  EFC35852.1   4 KQALCVGGTSGIGRALAIKFASQKFNVSIMGRSEEAGKEIIEEMKKLnpDGKFEMIKVDASLMKDIEKVCDEYKQNHDRLDYCVLSQGIASMNG--RTE 100
                 57899******************************************99999*************************************54443..444 PP

                 HHH.HHHHHHHHTHHHHHHHHHHHHHHH...HCTTEEEEEEEEG CS
   adh_short  98 eee.wervievNltgvflltravlpaml...kqssGrIvnvsSv 137
                  +e ++  +++ + g ++ +r++ + +    k+s  r+ +v S 
  EFC35852.1 101 TKEgIDVKLALHYYGRVMFVRQLQDLLRltsKNSDVRVLTVLSA 144
                 44447777888888888888777666656556666666666665 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.013
                 HHHHHHHHGGGTEEEEEEEESSBSSHHHH CS
   adh_short 160 trslakelaptgirvnavaPGlvdTdmak 188
                 +++l+ke  +++i  +  aPG+++T+  +
  EFC35852.1 179 MDQLSKEEGNQNIAFIHQAPGFIATQWGR 207
                 578999*******************9765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.4   0.0   6.5e-15   2.9e-11       3     118 ..      12     128 ..      10     152 .. 0.81

  Alignments for each domain:
  == domain 1  score: 43.4 bits;  conditional E-value: 6.5e-15
                   TTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTT.SEE..EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH-HHHH CS
  adh_short_C2   3 asgIGraiAkalaeeGaevvltdlneea.kkrveelaeelg.aev..lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpfletsreef 95 
                    sgIGra+A ++a++  +v ++ ++eea k+ +ee+++  +  ++  +++D++  +++e++ +e ++++++lD++v + gia   +g+  + ++e++
    EFC35852.1  12 TSGIGRALAIKFASQKFNVSIMGRSEEAgKEIIEEMKKLNPdGKFemIKVDASLMKDIEKVCDEYKQNHDRLDYCVLSQGIASM-NGR--TETKEGI 105
                   69**************************8887777777555333455************************************9.555..5679999 PP

                   HHHHHHHTHHHHHHHHHHHHHCT CS
  adh_short_C2  96 draldvnlyslfllakaalplmk 118
                   d  l+   y+ ++++++++ l++
    EFC35852.1 106 DVKLALHYYGRVMFVRQLQDLLR 128
                   **********9999999998443 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   0.0   2.6e-08   0.00012       4      91 ..       7      92 ..       5     103 .. 0.82
   2 ?   -1.3   0.0       0.4   1.8e+03      80     107 ..     162     189 ..     115     192 .. 0.73

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 2.6e-08
                EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHT..T-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE---- CS
          KR  4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaeleal..gaevevvaaDvsdkdavealleeikaeeppikGvihaAgv 91
                l +GG+ g+G++la   a++ + ++ +++Rs++a ++    i+e+++l  + + e++++D s  +++e++ +e+k++++++  ++ + g+
  EFC35852.1  7 LCVGGTSGIGRALAIKFASQ-KFNVSIMGRSEEAGKE---IIEEMKKLnpDGKFEMIKVDASLMKDIEKVCDEYKQNHDRLDYCVLSQGI 92
                679*************9988.57899*****554444...5666666533459************************9999888876666 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.4
                 S---EEEE---------TTT--HHHHHH CS
          KR  80 ppikGvihaAgvlrdklleemtaedleq 107
                  ++k    aAg+ +d +++++++e+ +q
  EFC35852.1 162 FTLKNAADAAGFYNDLAMDQLSKEEGNQ 189
                 5777778889999999999888887665 PP

>> PAE  Pectinacetylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   4.8e-07    0.0022      93     191 ..      73     177 ..      54     205 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 4.8e-07
         PAE  93 pdfynwNrvkvrYC...dg.asfsGdveev...dkstklyFrGqrilqaviedLlekglkkakkvlLsGcSAGglaailhcdklrellpkeakvkclsd 184
                  d y+ N+ ++ YC   +g as +G +e++   d +  l++ G+ ++   ++dLl+   k+++  +L+  SAG  + ++++d+l   l+++ ++k+ +d
  EFC35852.1  73 CDEYKQNHDRLDYCvlsQGiASMNGRTETKegiDVKLALHYYGRVMFVRQLQDLLRLTSKNSDVRVLTVLSAGVHSPYTKLDDLD--LKHNFTLKNAAD 169
                 56677777788888443223577787774324477889*********************************************97..8999*****999 PP

         PAE 185 a.GfFlda 191
                 a Gf+ d 
  EFC35852.1 170 AaGFYNDL 177
                 63888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      508  (0.028334); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 1906.29
//
Query:       EFC35853.1  [L=223]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-18   66.2   2.9    6.3e-05   22.8   0.0    4.8  4  NHL             NHL repeat
    0.00024   21.2   0.5        4.1    7.7   0.0    3.6  4  IreB            IreB regulatory phosphoprotein
     0.0035   17.7   0.1         28    5.1   0.0    3.8  4  Linker_histone  linker histone H1 and H5 family
  ------ inclusion threshold ------
      0.011   15.8   0.0         49    4.1   0.0    3.3  3  TGT_C2          Patch-forming domain C2 of tRNA-guanine trans
      0.019   15.1   0.0          6    7.1   0.0    3.3  4  E2_bind         E2 binding domain
        0.2   11.4   2.3         28    4.5   0.1    3.2  3  Ribosomal_S21   Ribosomal protein S21
       0.22   11.0   0.0        5.1    6.5   0.0    2.1  2  MHC_I_3         MHC-I family domain
       0.53   10.5   5.5         34    4.7   0.1    4.1  4  DUF1939         Domain of unknown function (DUF1939)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   7.1e-07    0.0016       1      27 [.       4      30 ..       4      31 .. 0.95
   2 !   13.8   0.1     2e-05     0.044      12      27 ..      70      85 ..      60      86 .. 0.87
   3 !   22.8   0.0   2.8e-08   6.3e-05       2      27 ..     116     141 ..     115     142 .. 0.85
   4 !    8.4   0.0     0.001       2.4       8      27 ..     178     197 ..     171     198 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 7.1e-07
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +nyP++v v+ nG++y++D+ n+rv++
  EFC35853.1  4 LNYPTSVFVSENGEVYISDYLNNRVRK 30
                79***********************86 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 2e-05
                TTEEEEEECCCTEEEE CS
         NHL 12 nGdiyVaDsenhrvqv 27
                n ++y++Ds nhr+++
  EFC35853.1 70 NEEVYITDSANHRIRK 85
                679***********86 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 2.8e-08
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n+P ++ v+snG+iy++Ds+n+r+++
  EFC35853.1 116 NCPMSTFVNSNGEIYITDSNNFRIRK 141
                 666666699***************86 PP

  == domain 4  score: 8.4 bits;  conditional E-value: 0.001
                 EEETTTEEEEEECCCTEEEE CS
         NHL   8 avdsnGdiyVaDsenhrvqv 27 
                  v+sn++ y++Ds+n+ +++
  EFC35853.1 178 FVSSNDEMYISDSGNNAIRK 197
                 5889************9986 PP

>> IreB  IreB regulatory phosphoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.8   4.1e+03      48      57 ..      18      27 ..      11      33 .. 0.74
   2 ?    2.4   0.0     0.081   1.8e+02      46      72 ..      71      95 ..      66      98 .. 0.79
   3 !    6.8   0.0    0.0034       7.6      41      72 ..     122     151 ..     118     154 .. 0.87
   4 !    7.7   0.0    0.0018       4.1      41      72 ..     178     207 ..     175     210 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.8
        IreB 48 tYitsyknAR 57
                 Yi+ y n R
  EFC35853.1 18 VYISDYLNNR 27
                6999998887 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.081
        IreB 46 dptYitsyknARslirkleRdelleel 72
                +  Yit   n    irk+ ++ ++e++
  EFC35853.1 71 EEVYITDSANH--RIRKVSKSGIIETI 95
                66799987665..599***99999986 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0034
        IreB  41 YllsgdptYitsyknARslirkleRdelleel 72 
                 ++ s+   Yit  +n R  irk++R+ +++++
  EFC35853.1 122 FVNSNGEIYITDSNNFR--IRKVQRNGIIKTI 151
                 66788889*******98..9********9976 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.0018
        IreB  41 YllsgdptYitsyknARslirkleRdelleel 72 
                 ++ s+d  Yi+   n  + irk+ R+ ++e++
  EFC35853.1 178 FVSSNDEMYISDSGN--NAIRKVSRNGIIETV 207
                 6789******98766..79**********976 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.026        59      41      66 ..      19      44 ..       2      51 .. 0.76
   2 ?    3.2   0.0      0.05   1.1e+02      45      69 ..      78     102 ..      65     106 .. 0.78
   3 ?   -0.8   0.0      0.89     2e+03      49      67 ..     138     156 ..     121     161 .. 0.69
   4 ?    5.1   0.0     0.013        28      46      67 ..     191     212 ..     170     221 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.026
  Linker_histone 41 kfksllkkalkkgvekgelvqpkgkG 66
                     ++ +l++ ++k +++g +v + g+G
      EFC35853.1 19 YISDYLNNRVRKVLQNGNIVTIAGNG 44
                    347799****************9966 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.05
  Linker_histone  45 llkkalkkgvekgelvqpkgkGasG 69 
                       ++ ++k  ++g+++ + g+G  G
      EFC35853.1  78 SANHRIRKVSKSGIIETIAGNGNEG 102
                     568999************9966544 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.89
  Linker_histone  49 alkkgvekgelvqpkgkGa 67 
                      ++k   +g+++ + g+G 
      EFC35853.1 138 RIRKVQRNGIIKTIAGNGN 156
                     5677777777777777665 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.013
  Linker_histone  46 lkkalkkgvekgelvqpkgkGa 67 
                      ++a++k   +g+++ + g+G+
      EFC35853.1 191 GNNAIRKVSRNGIIETVAGEGP 212
                     589***************9776 PP

>> TGT_C2  Patch-forming domain C2 of tRNA-guanine transglycosylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.024        54      31      67 ..      25      59 ..      10      63 .. 0.78
   2 ?    4.1   0.0     0.022        49      19      40 ..      68      89 ..      65     114 .. 0.84
   3 ?    3.8   0.0     0.028        63      23      41 ..     128     146 ..     120     159 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.024
      TGT_C2 31 tgrirqvlvdgerlatlraqdgrltLsleGarrlhes 67
                 +r+r+vl +g+ ++t+ a +g l  s  G+  ++  
  EFC35853.1 25 NNRVRKVLQNGN-IVTI-AGNGKLGCSGDGGLAINAE 59
                68******9886.6776.9999999999988877765 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.022
      TGT_C2 19 Lfpedvtitrsatgrirqvlvd 40
                +f+e+v it sa  rir+v   
  EFC35853.1 68 VFNEEVYITDSANHRIRKVSKS 89
                58899*************9874 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.028
      TGT_C2  23 dvtitrsatgrirqvlvdg 41 
                 ++ it s+  rir+v+ +g
  EFC35853.1 128 EIYITDSNNFRIRKVQRNG 146
                 4778999*********987 PP

>> E2_bind  E2 binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       2.7     6e+03      65      70 ..      18      23 ..       8      41 .. 0.53
   2 ?    0.0   0.0      0.43   9.6e+02      60      73 ..      68      81 ..      56      87 .. 0.71
   3 ?    7.1   0.0    0.0027         6      46      72 ..     110     136 ..     109     143 .. 0.87
   4 ?    3.1   0.0     0.049   1.1e+02      46      72 ..     166     192 ..     164     199 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.7
     E2_bind 65 itvtDk 70
                ++++D 
  EFC35853.1 18 VYISDY 23
                555443 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.43
     E2_bind 60 edgeeitvtDkklp 73
                + +ee+++tD++ +
  EFC35853.1 68 VFNEEVYITDSANH 81
                47899*****9876 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0027
     E2_bind  46 atrpNLekkLkeLvedgeeitvtDkkl 72 
                 at+  L+ +++ +v+++ ei++tD++ 
  EFC35853.1 110 ATQAQLNCPMSTFVNSNGEIYITDSNN 136
                 68999*******************985 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.049
     E2_bind  46 atrpNLekkLkeLvedgeeitvtDkkl 72 
                 at   L+ +++ +v++++e++++D+  
  EFC35853.1 166 ATNAQLNYPMHVFVSSNDEMYISDSGN 192
                 79999*******************875 PP

>> Ribosomal_S21  Ribosomal protein S21
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.13   2.8e+02      19      29 ..      84      94 ..      83      96 .. 0.89
   2 ?    4.5   0.1     0.012        28      19      30 ..     140     151 ..     139     152 .. 0.91
   3 ?    3.2   0.1     0.032        72      19      30 ..     196     207 ..     195     208 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.13
  Ribosomal_S21 19 rkveragvire 29
                   rkv+++g+i +
     EFC35853.1 84 RKVSKSGIIET 94
                   9*******986 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.012
  Ribosomal_S21  19 rkveragvirev 30 
                    rkv+r+g+i+++
     EFC35853.1 140 RKVQRNGIIKTI 151
                    9********975 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.032
  Ribosomal_S21  19 rkveragvirev 30 
                    rkv+r+g+i +v
     EFC35853.1 196 RKVSRNGIIETV 207
                    9********876 PP

>> MHC_I_3  MHC-I family domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0    0.0023       5.1     105     149 ..       1      45 [.       1      81 [. 0.85
   2 ?    2.4   0.0     0.042        94     103     129 ..     166     192 ..     163     202 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0023
                 HHSS-SSEEEEEEEEEEEESTTEEEEEEEEEETTEEEEEEETTEE CS
     MHC_I_3 105 elkleYPfevqlsaGCelhpgeasvsFlrvAyqgsdllsfqntsw 149
                 +++l+YP  v +s+  e+++ +  ++ +r   q  +++++ ++  
  EFC35853.1   1 MVQLNYPTSVFVSENGEVYISDYLNNRVRKVLQNGNIVTIAGNGK 45 
                 579**********************************99988764 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.042
                 HHHHSS-SSEEEEEEEEEEEESTTEEE CS
     MHC_I_3 103 vkelkleYPfevqlsaGCelhpgeasv 129
                 + + +l+YP++v +s   e+++ ++ +
  EFC35853.1 166 ATNAQLNYPMHVFVSSNDEMYISDSGN 192
                 56789***********99999877655 PP

>> DUF1939  Domain of unknown function (DUF1939)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.1      0.44   9.9e+02       3      21 ..      18      36 ..      10      45 .. 0.74
   2 ?    2.9   0.0     0.057   1.3e+02       3      17 ..      73      87 ..      72     104 .. 0.90
   3 ?    4.7   0.1     0.015        34       3      19 ..     129     145 ..     129     163 .. 0.81
   4 ?    1.8   0.1      0.13   2.8e+02       4      18 ..     186     200 ..     185     202 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.44
     DUF1939  3 vyindsnnwksrwvqskwa 21
                vyi+d  n++ r+v  + +
  EFC35853.1 18 VYISDYLNNRVRKVLQNGN 36
                7888888888777766544 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.057
     DUF1939  3 vyindsnnwksrwvq 17
                vyi ds+n + r+v+
  EFC35853.1 73 VYITDSANHRIRKVS 87
                8*********99997 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.015
     DUF1939   3 vyindsnnwksrwvqsk 19 
                 +yi dsnn + r+vq +
  EFC35853.1 129 IYITDSNNFRIRKVQRN 145
                 69************974 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.13
     DUF1939   4 yindsnnwksrwvqs 18 
                 yi+ds n+  r+v+ 
  EFC35853.1 186 YISDSGNNAIRKVSR 200
                 9********999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (223 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       370  (0.020637); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.43
# Mc/sec: 1572.29
//
Query:       EFC35854.1  [L=257]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0094   16.1   0.7        1.1    9.5   0.3    2.3  2  DUF4115    Domain of unknown function (DUF4115)
  ------ inclusion threshold ------
      0.098   12.3  14.3       0.13   11.9  14.3    1.1  1  Laminin_I  Laminin Domain I
       0.34   11.3   1.9       0.53   10.6   1.9    1.3  1  TM2        TM2 domain
        6.2    5.6   7.9        8.4    5.2   7.9    1.2  1  LMBR1      LMBR1-like membrane protein


Domain annotation for each model (and alignments):
>> DUF4115  Domain of unknown function (DUF4115)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.3   0.00024       1.1      26      68 ..      49      91 ..      45      96 .. 0.84
   2 !    4.5   0.0    0.0087        39      48      63 ..     111     126 ..     108     130 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00024
     DUF4115 26 lkaGetkevsgkppltltiGnagavevsvnGkpvdllgyargn 68
                ++ G+ +++++++p+++  Gnag  +  vn+ + ++ +y + +
  EFC35854.1 49 FSGGNYVNFNNAQPYQVSNGNAGYSQYYVNDGQQQPQSYVPPQ 91
                567889999999******************9999999985444 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0087
     DUF4115  48 gavevsvnGkpvdllg 63 
                 ++ ++ +nG+pvdl+ 
  EFC35854.1 111 SGFTMYINGQPVDLSN 126
                 68899********986 PP

>> Laminin_I  Laminin Domain I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9  14.3     3e-05      0.13      61     147 ..     160     245 ..     145     249 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3e-05
   Laminin_I  61 kkatqvlakaqkvnaesertlnnakeLaekikkladnikeilekvatlneneealpssklseelaeaqrlLeelrsRdftkqleeae 147
                  +a+++++ +  +++  e ++ + +   e+i+++++ni+  +e+  ++nen++ +  +++++++ ++ r+ + + s++++ ++++++
  EFC35854.1 160 RRAEENRRLHDSIRRTNESINRSNEIHRENIRRMNENIHRTNEQNRRTNENNMRMHHQNMNRMHDNM-RMHQNIHSQNMQRMHQQNT 245
                 5788999999999999999999999999************************************997.9***************998 PP

>> TM2  TM2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   1.9   0.00012      0.53      30      50 ..       1      20 [.       1      21 [. 0.93

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00012
         TM2 30 sGvlqlltfvGglgiwwlidl 50
                +G+++l+tf G++g+++++d+
  EFC35854.1  1 MGIVYLFTF-GLCGVGQIFDV 20
                69*******.********996 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   7.9    0.0019       8.4     216     309 ..     161     247 ..     122     256 .. 0.62

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0019
       LMBR1 216 keeaereledllkevkklrksisesdplrkyleeilkkvPeeiaeklksnenkteeslaklekqlikalqkrertekq.wkrllekalelediik 309
                 ++e +r+l    ++++++++si++s+   +   e ++ ++e+i+ ++++n+  +e+++   ++++ ++++++ r +++  +++++++ + ++ ++
  EFC35854.1 161 RAEENRRLH---DSIRRTNESINRSN---EIHRENIRRMNENIHRTNEQNRRTNENNMRMHHQNM-NRMHDNMRMHQNiHSQNMQRM-HQQNTMN 247
                 344445555...88888888888888...566666667777888787776666666666666333.333333333333033344443.3333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3002  (0.167438); expected 358.6 (0.02)
Passed bias filter:                      563  (0.0314016); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 1685.44
//
Query:       EFC35855.1  [L=268]
Description: hypothetical protein NAEGRDRAFT_60078 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5016  (0.27977); expected 358.6 (0.02)
Passed bias filter:                     1355  (0.0755759); expected 358.6 (0.02)
Passed Vit filter:                       815  (0.0454571); expected 17.9 (0.001)
Passed Fwd filter:                       339  (0.0189079); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 3.89u 0.38s 00:00:04.27 Elapsed: 00:00:00.77
# Mc/sec: 1049.67
//
Query:       EFC35856.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       397  (0.0221429); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.25s 00:00:00.69 Elapsed: 00:00:00.41
# Mc/sec: 1847.71
//
Query:       EFC35857.1  [L=697]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.7e-10   41.4   0.5    3.2e-09   37.3   0.2    2.4  2  PHM7_cyt   Cytosolic domain of 10TM putative phosphate transp
    8.1e-07   28.6  20.7    8.1e-07   28.6  20.7    2.7  3  RSN1_7TM   Calcium-dependent channel, 7TM region, putative ph
    7.4e-05   21.8   6.9    7.4e-05   21.8   6.9    3.5  4  Anoctamin  Calcium-activated chloride channel
  ------ inclusion threshold ------
       0.14   12.0   0.1         32    4.5   0.0    2.8  2  RRM_1      RNA recognition motif. (a.k.a. RRM, RBD, or RNP do
        4.7    6.7   9.5       0.34   10.4   1.8    2.4  2  Stevor     Subtelomeric Variable Open Reading frame


Domain annotation for each model (and alignments):
>> PHM7_cyt  Cytosolic domain of 10TM putative phosphate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.3   0.2   8.9e-13   3.2e-09       1     176 []     121     281 ..     121     281 .. 0.75
   2 ?   -4.1   0.0       4.5   1.6e+04      18      45 ..     652     679 ..     647     684 .. 0.79

  Alignments for each domain:
  == domain 1  score: 37.3 bits;  conditional E-value: 8.9e-13
    PHM7_cyt   1 srTvlvtgiPkelrse..eklkeffeelypgkvvesvqivrdvkkldklveerekavrkleaalskykkngkklpkkrpthklgflglkligkkvdaid 97 
                 +++v ++++P+       ++l ++f+++   k ++++ ++ d++++ k +++++++++++e++     + g             +   + + +k+  i 
  EFC35857.1 121 DYSVHIRDLPSTEAAHgkKRLYKHFSKFG--K-LDNIALALDCGDISKSIKKKDELIKEIEKCDIVISRGG-------------C---FVLIEKIKRI- 199
                 6899999**998854333999****9984..4.488***************************75444333.............2...2333666664. PP

    PHM7_cyt  98 yyrekleeldeeieeerekvkkkplgaaFvtfesersaaavak.......qakcaaqiqqssnptl..kpkkwtvelAPePrDviWeN 176
                 y++  l+ +++ i +  +k  ++ +g aF+tfe+e+s  ++++       q    + +  s+  t+  k+++++ve+A eP+D+iWeN
  EFC35857.1 200 YFSIYLNFIQKDIAKSMRKKAYRCTGDAFITFENEKSRFKCLHtfnrpmiQ----RIC--SKSGTYskKKHRIRVEPAHEPHDIIWEN 281
                 666666666777777777777999*****************9776644322....222..223333346789***************9 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 4.5
    PHM7_cyt  18 klkeffeelypgkvvesvqivrdvkkld 45 
                 + ++ f+++ p   v++v  v++  +l+
  EFC35857.1 652 DYRNGFDKYIPPIDVSNVKYVYHGEELE 679
                 5577899999888899999999888876 PP

>> RSN1_7TM  Calcium-dependent channel, 7TM region, putative phosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   3.5       1.5   5.4e+03     167     228 ..      37     100 ..      17     108 .. 0.51
   2 !   28.6  20.7   2.3e-10   8.1e-07       6     270 ..     296     571 ..     289     576 .. 0.80
   3 ?   -4.4   4.3       2.6   9.5e+03     214     241 ..     593     620 ..     568     631 .. 0.55

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 1.5
    RSN1_7TM 167 lflikrkflsktprdlaerytkppsfdygteypkvllifv..ialiYsviaPlilpfaliyfll 228
                 + ++  + + + p  ++ ++++ ps  ++  ++++ l ++  + +++ ++  +i +f+++y+ +
  EFC35857.1  37 VIFFVILSALHAPYLYFYAQKTNPSTFFQMSMANYDLNASggVNIAFGTLEVVIALFSIVYLRF 100
                 2222222222455555544445555555555555444333236666666777777777776655 PP

  == domain 2  score: 28.6 bits;  conditional E-value: 2.3e-10
    RSN1_7TM   6 tlllvlliifwiipvafvgllsnletltkvlpflkkilelskkllsvvtgllPtlllslllallpiilrllsklqGalsrselelsvvskyfa..Flv. 101
                  +l ++l+   ++ va+v  + + +++++ +++  +i + s + +++ ++l  ++l+ +l  ++ +il+lls+++ +  + + ++s++ k+ +  Fl  
  EFC35857.1 296 SFLATVLFSGAVVAVAVVLEVLKKDKFSS-ISISDWIENPSFQNWQIFASLGLSVLVFILVQVMTYILYLLSNFEKHRFQLNAKQSLMMKVTFgsFLTt 393
                 34444444444555555555555556665.788999966666677*****************************************9999865346541 PP

    RSN1_7TM 102 vnvFlvftlagtalslleeiid............nptsipkllaeslpkasnFfityillqglagaaleLlqlvklilflikrkflsktprdlaerytk 188
                 +  ++v+  + t+ s+ +e++d             + +ip l+ +s   +s Ff+t   +++   +  +Ll + + +l+  + + +s t++dl +  ++
  EFC35857.1 394 IAYLFVYLTSPTVGSYYSEMTDnsviipkgaftiGNANIPILVESSAWYSSLFFVTCTSVASN-TIKDALLGIYHYFLKRYRIA-TSVTQEDLNK-AHE 489
                 556666666668888888888888898888888888888888888888888888888888877.66677888888886666643.4478888877.55* PP

    RSN1_7TM 189 ppsfdygteypkvllifvialiYsviaPlilpfaliyfllgylvykyqllyvydtkyesgGklwpralnrllvglvlfqlll 270
                 pp ++y   y++ l  + i++++s + P+ l +++  +++ y+v+k ++l +y+ + +    l p+aln l ++ +l  +l+
  EFC35857.1 490 PPVYSYEYRYSYQLKNMFIGIVFSGLFPVSLFIITGGLMACYFVDKFNILKIYRAEGKEVDLLSPTALNFLSIAFLLRYILM 571
                 ******************************************************9988889999999999988888877777 PP

  == domain 3  score: -4.4 bits;  conditional E-value: 2.6
    RSN1_7TM 214 iaPlilpfaliyfllgylvykyqllyvy 241
                 +  +i p  +++f++  l+  y ++  +
  EFC35857.1 593 VLSIITPYHICFFSAFLLYIIYLIIHFF 620
                 3336666666666666555555555554 PP

>> Anoctamin  Calcium-activated chloride channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   1.2     0.038   1.4e+02     112     187 ..      15     107 ..       2     125 .. 0.39
   2 !   21.8   6.9   2.1e-08   7.4e-05     111     218 ..     287     399 ..     232     411 .. 0.67
   3 ?   -2.3   3.2      0.42   1.5e+03     107     176 ..     496     569 ..     470     624 .. 0.54
   4 ?   -2.4   0.3      0.45   1.6e+03     122     152 ..     597     628 ..     575     642 .. 0.64

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.038
   Anoctamin 112 ppwkrrlfrllvslplvllliclavvgvlilrcla.............lqelvssvke......................llsflptvlnlvlililne 175
                 p+wk  l+ l  s +l l + +l+v++++il+ l                       +                      +        + v+i +++ 
  EFC35857.1  15 PFWK--LTSLGRSSMLYLYISLLIVIFFVILSALHapylyfyaqktnpS--------TffqmsmanydlnasggvniafgT--------LEVVIALFSI 95 
                 6777..3322223323333333334443333222222222222333331........033333333445555533333221........2233333334 PP

   Anoctamin 176 vykklaiwltdl 187
                 vy ++  w+t+ 
  EFC35857.1  96 VYLRFLFWITNR 107
                 444444444443 PP

  == domain 2  score: 21.8 bits;  conditional E-value: 2.1e-08
   Anoctamin 111 yppwkrrlfrllvslplvllliclavvg.vlilrclalqelvssvke............lls...flptvlnlvlililnevykklaiwltdlEnhrtq 193
                 +++++rr + +l+++     l+  avv+  ++l +l+  ++     +            + +   +++++ + vl++il +v++++ + l ++E+hr q
  EFC35857.1 287 ISKYSRRSVSFLATV-----LFSGAVVAvAVVLEVLKKDKF-----SsisisdwienpsF-QnwqIFASLGLSVLVFILVQVMTYILYLLSNFEKHRFQ 374
                 333333333333333.....222233331333333332222.....01222345444541.1456********************************** PP

   Anoctamin 194 seyekslilKvflfqfvnsylslfy 218
                  + ++sl++Kv + +f+++ + lf+
  EFC35857.1 375 LNAKQSLMMKVTFGSFLTTIAYLFV 399
                 ****************999999986 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 0.42
   Anoctamin 107 eefyyppwkrrlfrllvslplvlllicl.avvgvlilrcla....l.qelvssvkells.flptvlnlvlilil.nev 176
                 e  y  + k+ ++ +++s     + + l ++ g l+ ++++    + +++  + ke+ + ++pt+ln++ i +l   +
  EFC35857.1 496 EYRYSYQLKNMFIGIVFSGL---FPVSLfIITGGLMACYFVdkfnIlKIYRAEGKEV-DlLSPTALNFLSIAFLlRYI 569
                 33444444434444444431...1222213333444432222222323333333332.24777777777766652333 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 0.45
   Anoctamin 122 lvslplvllliclavvgvlilrclal.qelvs 152
                 ++   ++++ ++l++++ li+ ++ + +++v+
  EFC35857.1 597 ITPYHICFFSAFLLYIIYLIIHFFTTgTNFVQ 628
                 33344566666666666666665665555554 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.011        40      13      33 ..     139     159 ..     136     167 .. 0.83
   2 ?    4.5   0.0    0.0088        32      34      61 ..     219     246 ..     211     251 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.011
                 HHHHHHHHTTSCEEEEEEEEE CS
       RRM_1  13 eeLkelFskfGpiksiklvrd 33 
                 + L+++FskfG+  +i l  d
  EFC35857.1 139 KRLYKHFSKFGKLDNIALALD 159
                 569*********999987766 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0088
                 TTTSEEEEEEEEESSHHHHHHHHHHHTT CS
       RRM_1  34 etgkskgfafVeFeskedAekAlealng 61 
                 +  + +g af++Fe++ +  k+l ++n+
  EFC35857.1 219 KAYRCTGDAFITFENEKSRFKCLHTFNR 246
                 55677889**********9999998886 PP

>> Stevor  Subtelomeric Variable Open Reading frame
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   1.8   9.4e-05      0.34     190     255 ..     298     364 ..     203     382 .. 0.63
   2 ?   -0.2   1.1      0.17   5.9e+02     209     253 ..     573     617 ..     494     621 .. 0.56

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 9.4e-05
      Stevor 190 lasslsilnlfsesslesalk.aavsaaaasdlagtaasaassafepygiaalvllilavvliiLYi 255
                 la++l    ++  + + ++lk  ++s+  +sd+  + +    ++f + g+++lv++++ v+  iLY+
  EFC35857.1 298 LATVLFSGAVVAVAVVLEVLKkDKFSSISISDWIENPSFQNWQIFASLGLSVLVFILVQVMTYILYL 364
                 333333333334444455566677888899999999999***************************7 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.17
      Stevor 209 lkaavsaaaasdlagtaasaassafepygiaalvllilavvliiL 253
                 ++  + +  + +  +++++ + s+++py i  +   +l ++ +i+
  EFC35857.1 573 ITRIYFTISLNYDPSNTSQPVLSIITPYHICFFSAFLLYIIYLII 617
                 2223333333334445588899********988766666665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (697 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       895  (0.0499191); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.79u 0.29s 00:00:01.08 Elapsed: 00:00:00.50
# Mc/sec: 4175.38
//
Query:       EFC35858.1  [L=123]
Description: CHY zinc finger domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.1e-12   45.3  12.7    1.5e-11   44.6  12.7    1.3  1  zf-CHY    CHY zinc finger


Domain annotation for each model (and alignments):
>> zf-CHY  CHY zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.6  12.7   8.3e-16   1.5e-11       1      64 [.      41     104 ..      41     118 .. 0.92

  Alignments for each domain:
  == domain 1  score: 44.6 bits;  conditional E-value: 8.3e-16
      zf-CHY   1 CkHykravvairapcCkklyaCreCHeeledhelerlevkevlcllCeteqekavlCkkCkkef 64 
                 C+Hyk++  ++r+ cC ++y+C+ CHe +++ + +    ++++c  C++eq  a++C+ C+k++
  EFC35858.1  41 CEHYKNSKRWFRFDCCGRAYPCDICHELECTAPSSDIMGRKMICGYCSREQGLAQTCHFCQKNL 104
                 **************************998999999999999*******************9964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       963  (0.0537119); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.36u 0.24s 00:00:00.60 Elapsed: 00:00:00.41
# Mc/sec: 904.74
//
Query:       EFC35859.1  [L=141]
Description: hypothetical protein NAEGRDRAFT_54708 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.8e-48  162.9   0.7    7.5e-48  162.8   0.7    1.0  1  DUF1768   Domain of unknown function (DUF1768)


Domain annotation for each model (and alignments):
>> DUF1768  Domain of unknown function (DUF1768)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  162.8   0.7   4.2e-52   7.5e-48      31     160 ..       3     134 ..       1     135 [. 0.96

  Alignments for each domain:
  == domain 1  score: 162.8 bits;  conditional E-value: 4.2e-52
     DUF1768  31 lealtyntaehymmaqKallfedtevaeeilak.spkeakalgrkvrnfdeedWeeekeevvregnlaKfsqneelrelLlatgdrelveasprDriWG 128
                 ++++t+ t+e+ymm+qKa lf+d+e+ae+il++ +pk++k+ grkv+nfd ++We++++++v+egn+aKf+qnee+r+ Ll+  d e veasp D+iWG
  EFC35859.1   3 IDGKTFVTCEQYMMYQKAQLFNDHEMAEKILKTsDPKQCKEFGRKVKNFDTNQWEANRDRIVYEGNYAKFTQNEEMRRDLLSRLDVEYVEASPYDKIWG 101
                 5789***************************777***************************************************************** PP

     DUF1768 129 iGlkadea.aeerekwkGkNlLGkalmevReel 160
                 iGl+++++ a++r++wkG NlLG++++++R++l
  EFC35859.1 102 IGLEEKDQrAHDRSQWKGLNLLGRIITQIRDDL 134
                 ****8877577*******************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 942.45
//
Query:       EFC35860.1  [L=755]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-08   35.1   2.7    3.1e-08   33.9   2.7    1.6  1  RGS         Regulator of G protein signaling domain
    0.00037   20.3   0.2    0.00081   19.1   0.2    1.6  1  RGS-like    Regulator of G protein signalling-like domain
  ------ inclusion threshold ------
      0.079   12.9   0.2        1.1    9.3   0.0    2.8  2  Holin_BhlA  BhlA holin family
      0.092   13.3   5.6       0.16   12.6   1.7    2.7  2  JHD         Jumonji helical domain
       0.12   12.3   0.6        1.3    8.9   0.1    2.6  2  RCC1_2      Regulator of chromosome condensation (RCC1) repea


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   2.7   8.6e-12   3.1e-08       2     102 ..     585     687 ..     584     705 .. 0.88

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 8.6e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-H..HHHHHHHHHHCSS.STTTTTTHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidk..klreelekrleke.qpsrklfeeaqeev 97 
                 le+ l++++  +++ +F +++++ e +  ++++e+fk + +++++k++a  I ++yl+p+sp eln +k  +++e++ k +e+      + f+++q ++
  EFC35860.1 585 LEHFLKSKKTFNILLDFARRSYCPESVLCYQDIERFKLT-NKKNRKQAALHITKTYLKPNSPLELNFPKlsQMFEQISKAIETTpLLETNFFDNIQWHC 682
                 7889999********************************.***************************96448999******997544567778888888 PP

                 HHHHH CS
         RGS  98 felle 102
                  e + 
  EFC35860.1 683 IEDMT 687
                 77774 PP

>> RGS-like  Regulator of G protein signalling-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.2   2.3e-07   0.00081      18      79 ..     595     656 ..     583     737 .. 0.84

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 2.3e-07
                 HHHHHHHHHHHS--HHHHHHHHHHHHTTS-TTHHHHHHHHHHHHHTSTT-TT-----HHHHH CS
    RGS-like  18 LavflnyvlsqfdPsallfylitdlykqgtsKetrrvaleifstFleknallrvpvpeslal 79 
                   ++l +      P ++l+y   + +k ++ K+ +++al i +t+l++n++l  + p+ +++
  EFC35860.1 595 FNILLDFARRSYCPESVLCYQDIERFKLTNKKNRKQAALHITKTYLKPNSPLELNFPKLSQM 656
                 4678888888889****************************************999976553 PP

>> Holin_BhlA  BhlA holin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.0   0.00029       1.1      17      47 ..     321     351 ..     318     374 .. 0.82
   2 ?   -0.5   0.1      0.34   1.2e+03      47      68 ..     682     703 ..     676     705 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00029
  Holin_BhlA  17 vLfvvllvYilkkqekreekqeerekkyqei 47 
                 v  v+llvYi+k  ++r+e  +e  k+  ++
  EFC35860.1 321 VSIVFLLVYITKMDSNRKETNHENLKSSMKV 351
                 5679**************9998776665555 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.34
  Holin_BhlA  47 iikkltekfeiveeikkdvdei 68 
                  i+++t+ fe + + +k+v +i
  EFC35860.1 682 CIEDMTDVFERLKSQNKEVRNI 703
                 6999*****9999999988877 PP

>> JHD  Jumonji helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1      0.14   4.9e+02      66      97 ..     142     175 ..     133     177 .. 0.73
   2 ?   12.6   1.7   4.3e-05      0.16      11      97 ..     659     744 ..     648     750 .. 0.72

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.14
         JHD  66 alkewtkkea..vaekeeeipetikpskLikdls 97 
                 +lk+++++++   ++ e++i ++ + +kLik l 
  EFC35860.1 142 QLKNYSRDDSedEEDDEKDIGNQAEEKKLIKYLR 175
                 6777776554004566788************875 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 4.3e-05
         JHD  11 eiEkklkteekfkfPsfetihWfvakrlleklkelneegkraaeylvkgakalltalkewtkkeavaekeeeipetikpskLikdls 97 
                 +i k+++t+ + +  +f+ i+W+  + + + +++l++++k+  + l +   a l+ l + ++    + ++++ +++ + ++ +kd++
  EFC35860.1 659 QISKAIETTPLLETNFFDNIQWHCIEDMTDVFERLKSQNKEVRNILKQWKVASLNDLTTSQQVTLHNITSND-TNNNNNQEELKDIK 744
                 48899*******************************999988888877766666666665554444443333.33344444456665 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.1   0.00038       1.3      13      29 ..       6      22 ..       4      23 .. 0.92
   2 ?    0.5   0.0      0.16   5.7e+02      13      24 ..      65      76 ..      63      79 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00038
      RCC1_2 13 aLtedGeVlcWGsNsdG 29
                +L+++G++++ G N+dG
  EFC35860.1  6 ILSSNGNLYSIGYNGDG 22
                799*************9 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.16
      RCC1_2 13 aLtedGeVlcWG 24
                aLt++G+++ +G
  EFC35860.1 65 ALTDNGRIFLCG 76
                8******98666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (755 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1639  (0.0914161); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.78u 0.29s 00:00:01.07 Elapsed: 00:00:00.49
# Mc/sec: 4607.60
//
Query:       EFC35861.1  [L=968]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.8e-35  116.9  10.1    1.1e-05   25.1   0.0    8.7  9  LRR_6         Leucine Rich repeat
    4.9e-21   74.3   0.7    8.2e-08   31.9   0.0    4.1  4  LRR_8         Leucine rich repeat
    7.4e-20   71.7   9.7    1.4e-19   70.8   9.7    1.4  1  ABC_membrane  ABC transporter transmembrane region
    6.3e-19   68.8   0.0    1.5e-18   67.6   0.0    1.7  1  ABC_tran      ABC transporter
    1.1e-16   60.6   5.7     0.0015   18.9   0.0    5.5  6  LRR_4         Leucine Rich repeats (2 copies)
    9.5e-08   31.6   0.0        9.6    7.2   0.0    7.4  7  LRR_1         Leucine Rich Repeat
     0.0001   22.3   0.0    0.00019   21.4   0.0    1.4  1  RsgA_GTPase   RsgA GTPase
     0.0045   16.7   0.1      0.011   15.4   0.1    1.6  1  AAA_29        P-loop containing region of AAA domain
  ------ inclusion threshold ------
      0.012   15.6   0.0      0.038   14.0   0.0    1.8  1  Dynamin_N     Dynamin family
      0.014   14.8   1.2       0.36   10.2   1.2    2.3  1  SMC_N         RecF/RecN/SMC N terminal domain
      0.047   13.8   0.4       0.13   12.4   0.4    1.7  1  MMR_HSR1      50S ribosome-binding GTPase
       0.27   11.5   1.2       0.83    9.9   0.3    2.0  2  AAA_22        AAA domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       3.5   5.2e+03       3      10 ..     554     561 ..     553     562 .. 0.87
   2 ?   -1.2   0.0         2     3e+03      15      24 .]     773     782 ..     771     782 .. 0.86
   3 !   21.8   0.0   8.5e-08   0.00013       5      24 .]     787     806 ..     784     806 .. 0.94
   4 !   17.8   0.0   1.6e-06    0.0024       5      23 ..     811     829 ..     808     829 .. 0.93
   5 ?    1.9   0.0      0.21   3.1e+02       4      23 ..     834     853 ..     831     854 .. 0.82
   6 !   25.1   0.0   7.3e-09   1.1e-05       5      24 .]     859     878 ..     856     878 .. 0.94
   7 !   13.7   0.1   3.3e-05     0.049       5      24 .]     883     902 ..     880     902 .. 0.93
   8 !   17.6   0.0   1.8e-06    0.0027       5      24 .]     907     926 ..     904     926 .. 0.92
   9 !   16.0   0.0     6e-06     0.009       5      22 ..     931     948 ..     928     949 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3.5
       LRR_6   3 thLteLdL 10 
                 ++Lt L+L
  EFC35861.1 554 PTLTDLNL 561
                 69*****9 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 2
       LRR_6  15 IgDeGaeaLa 24 
                 Ig eGa++++
  EFC35861.1 773 IGVEGAKSIS 782
                 999****996 PP

  == domain 3  score: 21.8 bits;  conditional E-value: 8.5e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+  N+IgDeGa++++
  EFC35861.1 787 LTSLDIGENQIGDEGAKSIS 806
                 9****************996 PP

  == domain 4  score: 17.8 bits;  conditional E-value: 1.6e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L +sgN IgDeG++++
  EFC35861.1 811 LTSLTISGNSIGDEGVKSI 829
                 9***************987 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.21
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+ ++s+N+ g +Ga+ +
  EFC35861.1 834 QLTSFNISYNETGVAGAKFI 853
                 59********9888888765 PP

  == domain 6  score: 25.1 bits;  conditional E-value: 7.3e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s+N+IgDeGa++++
  EFC35861.1 859 LTSLDISYNEIGDEGAKSIS 878
                 9****************996 PP

  == domain 7  score: 13.7 bits;  conditional E-value: 3.3e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L +sgN Ig eGa++++
  EFC35861.1 883 LTSLTISGNSIGVEGAKSIS 902
                 9****************996 PP

  == domain 8  score: 17.6 bits;  conditional E-value: 1.8e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+  N+IgDeGa++++
  EFC35861.1 907 LTLLDIGENQIGDEGAKSIS 926
                 899**************996 PP

  == domain 9  score: 16.0 bits;  conditional E-value: 6e-06
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 L++L +s N+IgDeGa+ 
  EFC35861.1 931 LKSLTISENQIGDEGAKF 948
                 9***************85 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       4.1   6.1e+03      11      25 ..     291     307 ..     290     313 .. 0.67
   2 !   19.6   0.0   3.9e-07   0.00058      20      61 .]     780     821 ..     773     821 .. 0.93
   3 !   31.9   0.0   5.5e-11   8.2e-08       2      61 .]     834     893 ..     833     893 .. 0.98
   4 !   30.3   0.3   1.8e-10   2.6e-07       2      61 .]     882     941 ..     881     941 .. 0.98

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 4.1
                 S--SEE-TTSSTT..-T CS
       LRR_8  11 NrltslddeaFkg..ls 25 
                 Nr++s++   Fk+  l+
  EFC35861.1 291 NRIKSVERRKFKSgeLN 307
                 78888888888764444 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 3.9e-07
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + + +++L++Ld+++N++    ++++s +++L+sL++sgN +
  EFC35861.1 780 SISEMKQLTSLDIGENQIGDEGAKSISEMKQLTSLTISGNSI 821
                 66789***********************************87 PP

  == domain 3  score: 31.9 bits;  conditional E-value: 5.5e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lts ++s N   + + ++ + +++L++Ld+s+N++    ++++s L++L+sL++sgN +
  EFC35861.1 834 QLTSFNISYNETGVAGAKFISEMKQLTSLDISYNEIGDEGAKSISELKQLTSLTISGNSI 893
                 79********************************************************87 PP

  == domain 4  score: 30.3 bits;  conditional E-value: 1.8e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL +s N++ + + ++ + +++L+ Ld+++N++    ++++s L++L+sL++s N++
  EFC35861.1 882 QLTSLTISGNSIGVEGAKSISEMKQLTLLDIGENQIGDEGAKSISELKQLKSLTISENQI 941
                 7*********************************************************98 PP

>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.8   9.7   9.5e-23   1.4e-19      27     273 ..     223     476 ..     219     477 .. 0.86

  Alignments for each domain:
  == domain 1  score: 70.8 bits;  conditional E-value: 9.5e-23
                   HHHHSSTCCHH........HHHHHHHHHHHHHHHHHHHHHHHHHHHH..HHHHHHHHHHHHHHHHHHHHCSTHHHHHHSCHHHHHHHHHHHHHHHHH CS
  ABC_membrane  27 dtlldkgdpet........ealnvysllllllglaqfilallqsyll..nvtgerlskrlrrklfkkilrqpmsffdtnsvGellsrltndvsklrd 113
                   +++++++++++            ++ l++ll+++ + ++ + ++y++  +++ + l+ +l+ ++++k+ r       + ++Gel+++++ d++++  
    EFC35861.1 223 SNFTMNNETNWfqenlplsNIFFQLTLVILLFTFNSMASLFNHQYFFatSKIWIPLIGALQGSILQKLNRIKSVERRKFKSGELNNLFAIDTRSVAM 319
                   556666666666666655433445567888888888999999999998899********************9999999*****************98 PP

                   HHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHTTTHHHHHHHHHHHH CS
  ABC_membrane 114 glgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgirtVkafgreeyflekfekal 210
                      + +  ++++l+++vg+++v +++g + +lv++  ++++ +v  +++k  +++  k  + ++++ +++ E+l+gir Vk +  e+++ ek ++a+
    EFC35861.1 320 DGIDIHEAWLMPLTLIVGIVLVFVFFGYS-SLVGVLAMIICGPVLPFLGKYQTSFAGKAAQFRDERIKHMSEILNGIRIVKFYVFEDKMKEKVNQAR 415
                   8889*************999999999997.8****************************************************************** PP

                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHHHH CS
  ABC_membrane 211 eeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailfga 273
                   e++++  +k+ ++ +    +t +l+ ++ + a++  t++   g+l++ ++++ l+lf ++  +
    EFC35861.1 416 EKEYSLLRKYVTVMSGY-CFTSSLMAIVGSGATF-VTFYYAGGDLTLPKMFTGLVLFGTFRLP 476
                   ******88888777755.5666666666666645.66666699**************999766 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.6   0.0     1e-21   1.5e-18       1     135 [.     556     693 ..     556     695 .. 0.74

  Alignments for each domain:
  == domain 1  score: 67.6 bits;  conditional E-value: 1e-21
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEET.TCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.................HH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................xx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilld.gkdlkeqeleslrkeigvlpqepqlfpeltvren.................es 81 
                 l +++lk+++g+++ ++G++G+GKStL++ ++g++  ++G+++++   +            i+   ++p l + + vren                  +
  EFC35861.1 556 LTDLNLKIERGKLYCVIGNTGSGKSTLISSIYGESVVKSGKVKVNpLCN------------ISLSDETPWLINAS-VRENivfdknltfdrerynriLD 641
                 6799**************************************7774333............33333444443333.44444333334322223444455 PP

                 HTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEEST CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  82 deeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEp 135
                   ++ + ls++ + +  +t ++ s+ +LSgGqk r++lara  ++++++l+D  
  EFC35861.1 642 VCQLRDDLSRFPNYD--KTEIGFSGINLSGGQKHRISLARACYSNSEIVLMDST 693
                 555777777777666..88888999***************************76 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.2       1.2   1.9e+03      23      31 ..      13      21 ..       4      24 .. 0.68
   2 !    6.6   0.0    0.0072        11      17      38 ..     782     799 ..     779     806 .. 0.76
   3 !   18.9   0.0     1e-06    0.0015       1      39 [.     785     821 ..     785     825 .. 0.86
   4 !   13.9   0.1   3.8e-05     0.056       1      33 [.     809     843 ..     809     846 .. 0.92
   5 !   18.5   0.0   1.3e-06     0.002       1      39 [.     857     893 ..     857     897 .. 0.87
   6 !   17.3   0.0   3.1e-06    0.0047       1      38 [.     905     943 ..     905     945 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.2
                TT--EEE-. CS
       LRR_4 23 pnLkeLdLs 31
                + L+eLdL+
  EFC35861.1 13 DELEELDLN 21
                678899984 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0072
                 S-HHH-TT--EEE-.-S----- CS
       LRR_4  17 plleklpnLkeLdLsgNnlitd 38 
                 +    +++L++Ld+ +N +i+d
  EFC35861.1 782 SE---MKQLTSLDIGEN-QIGD 799
                 33...999999999555.8876 PP

  == domain 3  score: 18.9 bits;  conditional E-value: 1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++Ld++ Nq+ d +   ++ +++L++L++sgN    ++
  EFC35861.1 785 KQLTSLDIGENQIGDEGAksISEMKQLTSLTISGN----SI 821
                 58*************99986445************....54 PP

  == domain 4  score: 13.9 bits;  conditional E-value: 3.8e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 ++L++L +s+N + d +   ++k+++L+++++s N
  EFC35861.1 809 KQLTSLTISGNSIGDEGVksIRKMKQLTSFNISYN 843
                 58*************99998889*********999 PP

  == domain 5  score: 18.5 bits;  conditional E-value: 1.3e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++Ld+s N + d +   ++ l++L++L++sgN    ++
  EFC35861.1 857 KQLTSLDISYNEIGDEGAksISELKQLTSLTISGN----SI 893
                 58*************99986445************....55 PP

  == domain 6  score: 17.3 bits;  conditional E-value: 3.1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L+ Ld++ Nq+ d +   ++ l++Lk+L++s+N +i+d
  EFC35861.1 905 KQLTLLDIGENQIGDEGAksISELKQLKSLTISEN-QIGD 943
                 589************99986445*********999.8876 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       5.9   8.9e+03       2       8 ..      15      21 ..      14      42 .. 0.79
   2 ?    3.4   0.0      0.11   1.6e+02       1      21 [.     786     806 ..     786     808 .. 0.87
   3 ?    4.0   0.0     0.072   1.1e+02       1      22 [.     810     831 ..     810     832 .. 0.86
   4 !    7.2   0.0    0.0064       9.6       1      23 []     858     880 ..     858     880 .. 0.90
   5 ?    3.3   0.0      0.13   1.9e+02       1      21 [.     882     902 ..     882     904 .. 0.85
   6 ?    2.2   0.0      0.29   4.4e+02       2      23 .]     907     928 ..     906     928 .. 0.88
   7 ?   -0.2   0.0       1.7   2.5e+03       1      15 [.     930     944 ..     930     951 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 5.9
       LRR_1  2 LrhLdLs 8 
                L++LdL+
  EFC35861.1 15 LEELDLN 21
                99***94 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld++ n++++ ++ s++
  EFC35861.1 786 QLTSLDIGENQIGDEGAKSIS 806
                 599*********999999886 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.072
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L +s+n++++ +  s+ +
  EFC35861.1 810 QLTSLTISGNSIGDEGVKSIRK 831
                 599*********9999888765 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0064
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++Ld+s+n +++ ++ s++ L
  EFC35861.1 858 QLTSLDISYNEIGDEGAKSISEL 880
                 599*********99999999865 PP

  == domain 5  score: 3.3 bits;  conditional E-value: 0.13
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L +s+n+++  ++ s++
  EFC35861.1 882 QLTSLTISGNSIGVEGAKSIS 902
                 599*********888888876 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.29
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ Ld++ n++++ ++ s++ L
  EFC35861.1 907 LTLLDIGENQIGDEGAKSISEL 928
                 899********99999999865 PP

  == domain 7  score: -0.2 bits;  conditional E-value: 1.7
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L +s n++++ 
  EFC35861.1 930 QLKSLTISENQIGDE 944
                 59********99665 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.0   1.3e-07   0.00019      53     131 ..     514     598 ..     484     601 .. 0.74

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 1.3e-07
                  EE-GGG--HHH...HHHHHHHHHHHTTSE..EEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT-----S--- CS
  RsgA_GTPase  53 lnKiDlleeee...eleelkeelealgye..vllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinallpelelktgevs 131
                   nK++l e +e   e+++++++ +a++++   + +s+++  +l++l+ +++  k+ +++G++G GKStLi ++ +e  +k g+v+
   EFC35861.1 514 ENKANLWEYDEeqtEFSSIMDNDTAIECKdaSIGWSEEEAPTLTDLNLKIERgKLYCVIGNTGSGKSTLISSIYGESVVKSGKVK 598
                  57777776655445677777777777776224556778888999***999988***********************999998886 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.1   7.5e-06     0.011      17      40 ..     561     584 ..     555     593 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 7.5e-06
      AAA_29  17 ieidlkgatlltGpsGsGKSTllD 40 
                 ++i++   + ++G++GsGKSTl+ 
  EFC35861.1 561 LKIERGKLYCVIGNTGSGKSTLIS 584
                 6677555999************95 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   2.6e-05     0.038       3      31 ..     571     599 ..     570     652 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.6e-05
                 EEEBTTTTHHHHHHHHHTS--S---SSS- CS
   Dynamin_N   3 vvGsqSsGKSSvlnaLlgedilprgpnpt 31 
                 v+G++ sGKS+++ ++ ge +  +g+  +
  EFC35861.1 571 VIGNTGSGKSTLISSIYGESVVKSGKVKV 599
                 9*******************988876654 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   1.2   0.00024      0.36      26     209 ..     568     736 ..     560     743 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00024
                 EEEEEESTTSSHHHHHHHHHHHCTT.TTTTTTCHCCCCCC--BTTCSSTTEEEEEEEEEETTEESSSSSSCEEEEEEEETTSEEEEEETTEEE-HHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N  26 ftaivGpNGSGKsnlldAilFvLGersakklrseklsdlihkskekasvkkaeveitfdnedkklkiekeevsisrrvkrkgeseykingkevtkkevs 124
                 + +++G+ GSGKs l+ +i +  +  ++ k++ + l ++   s+e + + +a+v   +        + +++++  r+ ++      ++ +   ++ ++ 
  EFC35861.1 568 LYCVIGNTGSGKSTLISSI-YGESVVKSGKVKVNPLCNISL-SDETPWLINASVRENI--------VFDKNLTFDRERYNRILDVCQLRDDLSRFPNYD 656
                 5689***************.544444555566666665555.4888888888887642........333446666777766666777777777777777 PP

                 HHHHCTT-STTCS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHH.HHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 125 ellesagiskelLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvk.kvaellkeksknaQfivislreemlekadklv 209
                 +   + g+s  +LSgG+k  ++la       ++ + ++l+D     +D+k  + ++ e +    k+   i ++++ ++le ad+++
  EFC35861.1 657 K--TEIGFSGINLSGGQKHRISLA----RACYSNSEIVLMDSTLNSIDAKLCRkIFNECICGFLKDRTRILVTHSLQLLEMADEVI 736
                 6..477777788888888766554....4567777788888877777777644044567777777777788888888888887765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.4   8.5e-05      0.13       3      28 ..     570     596 ..     569     602 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 8.5e-05
                 EEEESTTSSHHHHHHHHHTS.TEEESS CS
    MMR_HSR1   3 aivGrpNvGKStLinaltge.kaivsd 28 
                 +++G++ +GKStLi+++ ge +++ ++
  EFC35861.1 570 CVIGNTGSGKSTLISSIYGEsVVKSGK 596
                 79****************985555554 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.3   0.00056      0.83       4      24 ..     565     585 ..     562     600 .. 0.87
   2 ?   -1.0   0.0       1.3     2e+03      52     117 ..     693     757 ..     668     767 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00056
      AAA_22   4 tagilvvtGesGtGKTtllrr 24 
                 + ++ +v+G +G+GK+tl+  
  EFC35861.1 565 RGKLYCVIGNTGSGKSTLISS 585
                 678899***********9865 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.3
      AAA_22  52 sskdllrellralglelka..erlsseellealeqalraravielliiDEaqhlrseealeeLrslln 117
                 ++ ++  +l+r++ +e+      ++++ l+++  q l+ ++   +++ ++   +  +  l+e+++ ++
  EFC35861.1 693 TLNSIDAKLCRKIFNECICgfLKDRTRILVTHSLQLLEMADE--VIVFENGKLI-AKGSLKEIKNSYD 757
                 466666777777776666666778888899999999999988..9999998888.7888888877666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (968 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       755  (0.0421105); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.86u 0.34s 00:00:01.20 Elapsed: 00:00:00.53
# Mc/sec: 5481.45
//
Query:       EFC35862.1  [L=260]
Description: hypothetical protein NAEGRDRAFT_76478 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0029   17.4   0.1     0.0062   16.4   0.1    1.4  1  F-box     F-box domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.1   3.4e-07    0.0062       9      41 ..      21      53 ..      16      57 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 3.4e-07
                HHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHH CS
       F-box  9 evlrhILerLplsdllalrrVSkgwrilidsdr 41
                ++l  ++++L+l++l+al +VS  +++ i +++
  EFC35862.1 21 DILSLVFQFLELKELFALQKVSPFFYRTIEHLK 53
                7999**********************9998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.31s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 1638.34
//
Query:       EFC35863.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      2e-07   30.5   2.8    1.9e-05   24.0   0.9    2.2  2  G-alpha        G-protein alpha subunit
  ------ inclusion threshold ------
      0.015   15.1   2.0      0.037   13.8   2.0    1.6  1  Orthopox_B11R  Orthopoxvirus B11R protein


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0   0.00047       4.2      94     155 ..      52     117 ..       5     162 .. 0.65
   2 !   24.0   0.9   2.1e-09   1.9e-05     244     348 ..     205     309 ..     166     312 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.00047
                 -SS-SCCCS-HCHHHH............................HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCGCCTT- CS
     G-alpha  94 lkerldplkkveasliaklssateee..................qeiefnpraevgedikaLwndpgiqelyerrnkikl 155
                 +++r+++  ++e+            +                    +++++  ++ e++++Lw++p+++e y  +  +++
  EFC35863.1  52 IENRIENAANYEKV-----------KseclkgihqrlvkyfpvhFHDTVSE--KIEEQLVDLWHSPNFKEEYFAN-RFQV 117
                 22222333333332...........12334344344466654445555555..99**************998755.5654 PP

  == domain 2  score: 24.0 bits;  conditional E-value: 2.1e-09
                 S-TTSBHHHHHHHHHHCCCC-.GGGTTSEEEEEEE-HHHHHHHCCCS-GGG.......CCTT--H.CCHHHHHHHHHHHH.HHCCCCCCE...SGGSCE CS
     G-alpha 244 edekvnrleeslklFkeicnn.kllkntpiiLflnKlDileeKlkkgklsk.......yfpsyegrkndlesvlkylrnk.Feeihkeks...nnrrki 330
                  de           F ++c + + + ++++iL++++lD+l+eK+k g ++        + ++++  +++    ++yl+++  ++i +++     ++r++
  EFC35863.1 205 LDE-----------FYQVCRRlSGFSTYRMILIFTHLDVLNEKIKLGLINFggdkdieIRKEFNHIPKECALIIEYLIKEaIKNI-EMNPshdFPNRTL 291
                 444...........88889887789*******************99955542244444458888999999999**9995414444.33322456668** PP

                 EEEEE-TT-HHHHHHHHH CS
     G-alpha 331 ythftsatdtkevqkvie 348
                  +h++++    ++++ ++
  EFC35863.1 292 EYHIVNTSSDSDMKELLD 309
                 ******999999888765 PP

>> Orthopox_B11R  Orthopoxvirus B11R protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   2.0   4.1e-06     0.037      11      66 ..     256     312 ..     247     315 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.1e-06
  Orthopox_B11R  11 ineidrekeeilknveiennkninknhpsGyir...ealvintssnsdsidkeviecic 66 
                     n i +e   i+  +  e  kni+ n    +     e  ++ntss+sd   ke+++cic
     EFC35863.1 256 FNHIPKECALIIEYLIKEAIKNIEMNPSHDFPNrtlEYHIVNTSSDSDM--KELLDCIC 312
                    57788888888888888999999888665554411266799***99885..******** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 2303.80
//
Query:       EFC35864.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.44
# Mc/sec: 853.00
//
Query:       EFC35865.1  [L=115]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.038   13.3   9.5      0.045   13.0   9.5    1.1  1  Moulting_cycle   Moulting cycle
       0.04   14.5   3.6       0.31   11.6   3.4    2.1  1  TetR_C_19        Tetracyclin repressor-like, C-terminal domai
      0.042   14.3   6.1      0.054   14.0   5.4    1.6  1  TFIIS_M          Transcription factor S-II (TFIIS), central d
      0.097   12.8   5.5       0.12   12.5   5.5    1.2  1  Gti1_Pac2        Gti1/Pac2 family
       0.28   11.4  10.1       0.31   11.3  10.1    1.1  1  RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc3
       0.32   10.3   6.9       0.39   10.0   6.9    1.1  1  PPL5             Prim-pol family 5
       0.63   10.2   2.8        1.3    9.2   2.8    1.6  1  UPF0767          UPF0767 family
        2.2    7.0   5.4        2.6    6.7   5.4    1.0  1  Presenilin       Presenilin


Domain annotation for each model (and alignments):
>> Moulting_cycle  Moulting cycle
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   9.5     2e-05     0.045      14      92 ..      34     112 ..      25     115 .] 0.81

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2e-05
  Moulting_cycle  14 ralknkekeskWqdiierikeeserikkrkkveellkkrlsvfseakkklldprkaleea.elkkekkikedeslkeled 92 
                     ++ k+k+k sk++ +   i ++ ++ k  k++e++ kk+ +   + +kk  ++r++ +++ ++++e+++ e++s  +++d
      EFC35865.1  34 KISKHKNKLSKYRGVFRTIASNLKKKKGAKQNESVKKKKTELEETISKK-RKEREENNDSgSSSCEEETIEEDSTDDMSD 112
                     789****************************999999998865555554.444444444458899999999999999999 PP

>> TetR_C_19  Tetracyclin repressor-like, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   3.4   0.00014      0.31       6      62 ..       4      57 ..       1      95 [. 0.81

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00014
   TetR_C_19  6 yeeffeklldeiseeenakffkniflnmnykiekkftkefkkkkkkerlkelyelid 62
                +  +fek +++++++e + +fk if  m +ki+k+ +++ +k+++   ++ + ++++
  EFC35865.1  4 CSTYFEKSITKLNQDERKLLFKIIFDAMGWKISKH-KNKLSKYRGV--FRTIASNLK 57
                6789************************9988877.4444444332..445555555 PP

>> TFIIS_M  Transcription factor S-II (TFIIS), central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   5.4   2.4e-05     0.054      41      84 ..      25      78 ..       3      91 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.4e-05
                H..........HT------HHHHHHHHHHHHHS-TT-HHHHHTSSSS--STTTT CS
     TFIIS_M 41 e..........kekkstdkkykqkvrslvfNLkdkkNpeLrrrvlsgeispekl 84
                +          +++k+  +ky+  +r++ +NLk+kk ++  ++v +++ + e+ 
  EFC35865.1 25 KiifdamgwkiSKHKNKLSKYRGVFRTIASNLKKKKGAKQNESVKKKKTELEET 78
                3333366666656777889******************99999999999988765 PP

>> Gti1_Pac2  Gti1/Pac2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   5.5   5.1e-05      0.12      60     128 ..      29      97 ..      11     114 .. 0.59

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.1e-05
                 -S--B---EEETTEEEEEB-------------------------------.................-- CS
   Gti1_Pac2  60 DGvsWSpSrilgnfLvYreldkkrakkkkkkkkkkskestkkeesksekasssssesseakessssses 128
                 D++ W  S+  ++   Yr + ++ a++ kkkk +k++es kk++++ e++ s+++++ e++++s ss+ 
  EFC35865.1  29 DAMGWKISKHKNKLSKYRGVFRTIASNLKKKKGAKQNESVKKKKTELEETISKKRKEREENNDSGSSSC 97 
                 999*****************6666666655555555555555555444433333333222222222211 PP

>> RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc31
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3  10.1   0.00014      0.31     151     209 ..      53     114 ..      14     114 .. 0.55

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00014
  RNA_pol_3_Rpc31 151 kgkskkkk...eadeedeegkelleklkelaeeeddeeekkekedeeeee.eeeeddefdddd 209
                      + + kkkk   ++++ ++++ el+e+++++++e ++++++      eee  ee+  d+ +dd+
       EFC35865.1  53 ASNLKKKKgakQNESVKKKKTELEETISKKRKEREENNDS-GSSSCEEETiEEDSTDDMSDDE 114
                      3344444433233333444444555555544444443222.2222223334677777777776 PP

>> PPL5  Prim-pol family 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   6.9   0.00017      0.39     180     237 ..      57     112 ..      28     113 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00017
        PPL5 180 aeakgveeveeksskkkskekkkklkkktsrkkkkegkkekesekeeededeeddlsd 237
                 +++kg+++  ++s kkk++e +++++kk +++++++++ +++ e+e+ +ed+ dd+sd
  EFC35865.1  57 KKKKGAKQ--NESVKKKKTELEETISKKRKEREENNDSGSSSCEEETIEEDSTDDMSD 112
                 22233333..334444445555555566566666666667777888899999***998 PP

>> UPF0767  UPF0767 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   2.8   0.00058       1.3      33      67 ..      66     100 ..      54     111 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00058
     UPF0767  33 sllsdkytpyeksisekReeRlleeelnkdvtqve 67 
                 + ++ k+t+ e++is kR+eR+ ++++++   + e
  EFC35865.1  66 ESVKKKKTELEETISKKRKEREENNDSGSSSCEEE 100
                 5678999999*************999887665555 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   5.4    0.0011       2.6     204     289 ..      17     104 ..      10     114 .. 0.29

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0011
  Presenilin 204 qerneeifpaLiYsatvvvlaaeek...kaevaeseeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaees 289
                 q+  + ++  +i++a  + ++++++   k +   ++ +++ +kkk +++++s +++++e +++ s++++e+ee++++ ss+ e+++ e+
  EFC35865.1  17 QDERK-LLFKIIFDAMGWKISKHKNklsKYRGVFRTIASNLKKKKGAKQNESVKKKKTELEETISKKRKEREENNDSGSSSCEEETIEE 104
                 44444.44557777776666555543421111111111111111111111111111111111111111112222222222222222111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (115 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2908  (0.162195); expected 358.6 (0.02)
Passed bias filter:                      826  (0.0460706); expected 358.6 (0.02)
Passed Vit filter:                       103  (0.00574488); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 792.66
//
Query:       EFC35866.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   15.2   0.1      0.018   14.8   0.1    1.2  1  CPDase    Cyclic phosphodiesterase-like protein
       0.11   12.4   0.5       0.17   11.8   0.5    1.2  1  PID_2     Phosphotyrosine interaction domain (PTB/PID)


Domain annotation for each model (and alignments):
>> CPDase  Cyclic phosphodiesterase-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.1     2e-06     0.018      87     144 ..      29      89 ..       4      99 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2e-06
      CPDase  87 Yfkkvvlevkkdkellslaqlireafveaedeas...qraaewvkeefePHvSLlYsDisl 144
                   k+ ++e kk+k +++  +l+ ++f++ + +      +++++  ++++PH  +lYs ++ 
  EFC35866.1  29 MMKQSLIEGKKQKKVKKTSKLTSKDFINSPRDPLndsLKQDSKQFSNYHPHQNILYSQLYN 89 
                 566778889999999***********99998776555677889999***********9985 PP

>> PID_2  Phosphotyrosine interaction domain (PTB/PID)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.5   1.9e-05      0.17      98     165 ..       9      78 ..       4      85 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.9e-05
       PID_2  98 havlvkkeekakalaelLeqtleaaleefkrekllrqkarlslaaavadspsvPkrkll.akgt..lnyrP 165
                 ha    k++ +++  e L+++++++l e k++k+++++ +l+ +    +sp+ P+   l + ++   ny+P
  EFC35866.1   9 HAKASVKQSLTEEQLEKLHNMMKQSLIEGKKQKKVKKTSKLT-SKDFINSPRDPLNDSLkQDSKqfSNYHP 78 
                 7877888888999999*************************8.6678889999999999555554567777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1462  (0.0815439); expected 358.6 (0.02)
Passed bias filter:                      605  (0.0337442); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 1221.05
//
Query:       EFC35867.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.1   13.3   0.3       0.35   11.6   0.2    1.8  2  Pre-PUA   Pre-PUA-like domain


Domain annotation for each model (and alignments):
>> Pre-PUA  Pre-PUA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.29   5.1e+03      39      64 ..     103     130 ..      80     138 .. 0.53
   2 ?   11.6   0.2     2e-05      0.35      14      50 ..     199     235 ..     194     249 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.29
     Pre-PUA  39 ellpkke..evkvvklqgehvelyvvdg 64 
                 e++ k     ++ v++  + +++y+vd+
  EFC35867.1 103 EFVFKSDsaLLHSVRFATDGLSFYFVDQ 130
                 3333322124555666677778888775 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 2e-05
     Pre-PUA  14 ksSdrrkLraklleqfpslseeqleellpkkeevkvv 50 
                 +sS++r++r++l   f s +ee+l++ +p +   +++
  EFC35867.1 199 SSSQAREIREQLSYDFLSEDEEELQNAFPGQHVASHQ 235
                 69***************************87765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       926  (0.0516482); expected 358.6 (0.02)
Passed bias filter:                      626  (0.0349155); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1414.53
//
Query:       EFC35868.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       331  (0.0184617); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 778.00
//
Query:       EFC35869.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       770  (0.0429472); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 2019.71
//
Query:       EFC35870.1  [L=587]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.7e-06   26.0  30.7     0.0037   17.6  11.5    2.7  2  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6  11.2   3.8e-06     0.068       5      32 .]     508     533 ..     504     533 .. 0.79
   2 !   17.6  11.5   2.1e-07    0.0037       6      32 .]     547     572 ..     543     572 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3.8e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG+C  + G C C+sg+ G++C
  EFC35870.1 508 ETVCNGHGQCQ-EDGSCLCSSGF-GDQC 533
                 789*******8.3589******7.6666 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 2.1e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g G C +   +C+C++g++G +C
  EFC35870.1 547 NVCNGYGNCTSYD-NCSCNAGWSGQYC 572
                 67*******9555.8************ PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (587 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 3386.90
//
Query:       EFC35871.1  [L=406]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      7e-08   33.6   0.1    8.1e-07   30.2   0.1    2.3  1  ADH_zinc_N_2  Zinc-binding dehydrogenase
    3.4e-06   27.0   0.0    7.8e-06   25.9   0.0    1.5  1  ADH_zinc_N    Zinc-binding dehydrogenase


Domain annotation for each model (and alignments):
>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.2   0.1     9e-11   8.1e-07       1     133 []     232     403 ..     232     403 .. 0.66

  Alignments for each domain:
  == domain 1  score: 30.2 bits;  conditional E-value: 9e-11
                   TT-SEEEETTSTTHH..................HHH-TT-EEEEEES-H.HHHH.HHHHHHE....EEEEE.EEE--.--................. CS
  ADH_zinc_N_2   1 lGAdevidyrtedfe..................aatggegvDvvldtvg.gealleaslkvl....pggGr.lvsig.gpp................ 56 
                   +GAd vidy++++ +                  ++ g   vD+vld+vg +e +++++++      +  G  + +i+ + +                
    EFC35871.1 232 MGADVVIDYTKTSSKpridgesenlksicqtikEDHGDSYVDIVLDCVGgTEMYYRDVCNNFeckkARDGVaFTTISpN-Vpfepnmglsslmkigy 327
                   59********999999*************99975555688*********855555666543345464447746777744.36999999999988864 PP

                   ..S-EEE-CHHHCTTT-EEEE--GGG...-.-HHHHHHHHHHH.HHHH--...--EEEEEEGGG..HHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  57 ..lsaallkpakkrkgrsvkyeflfsmkasaqadileelaali.eeGklr...pvvdrvfplee..aaeAhrylesgrarGKiVl 133
                     +s+++       +++  +++f+f m ++  +d ++ l++ i  ++++    p    +f++++  +++Ah+++es r++GKiV+
    EFC35871.1 328 fvVSNKIKS----LSSAYPSFHFVF-MDKN-VKD-MNLLMNHIvISNQVYnqlPLM--EFEFSAqgLNDAHKQMESQRTVGKIVI 403
                   333333222....344444555555.5666.666.544444321333332111333..35555566******************7 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.0   8.7e-10   7.8e-06      18      69 ..     217     281 ..     211     288 .. 0.80

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 8.7e-10
                 EEEESSHHHHHHHHHTTESEEEET.............TTC.HHHHHHHHHTTTSSEEEEEESSCSH CS
  ADH_zinc_N  18 iavdsseeklelakklGadeviny.............kea.dlverikeltggegvdvvfecvGsg 69 
                 + ++ se++++++ k+Gad+vi+y             ++  ++ + ike  g+  vd+v++cvG g
  EFC35871.1 217 VYAVCSERNIDIVTKMGADVVIDYtktsskpridgesENLkSICQTIKEDHGDSYVDIVLDCVG-G 281
                 455667789***************999888888877655555777777777999**********.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (406 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.25s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2709.89
//
Query:       EFC35872.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.2e-26   90.5  11.5    6.7e-06   25.9   0.1    6.5  6  NHL             NHL repeat
    9.1e-06   25.9   1.9        3.5    8.0   0.0    5.0  5  Linker_histone  linker histone H1 and H5 family
     0.0069   16.5   1.2        2.6    8.2   0.1    3.8  5  B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domai
     0.0072   16.7   0.2         29    5.1   0.0    4.3  5  ComGF           Putative Competence protein ComGF
  ------ inclusion threshold ------
      0.014   15.3   0.2        3.2    7.8   0.0    3.6  4  HP1451_C        HP1451 C-terminal domain
      0.028   14.1   0.3      0.053   13.2   0.3    1.5  1  UNC-93          Ion channel regulatory protein UNC-93
       0.05   13.2  28.7        1.3    8.7   0.4    6.5  8  Plasmo_rep      Plasmodium repeat family
       0.19   11.2   0.8         42    3.5   0.0    3.8  5  Peptidase_A3    Cauliflower mosaic virus peptidase (A3)
        0.3    9.9   0.4         12    4.6   0.0    2.6  3  DUF4551         Protein of unknown function (DUF4551)
       0.85    9.1   6.6        5.5    6.4   0.1    3.7  4  BcrAD_BadFG     BadF/BadG/BcrA/BcrD ATPase family
       0.87    8.3   4.0       0.69    8.6   0.3    2.5  4  DPPIV_N         Dipeptidyl peptidase IV (DPP IV) N-terminal r
        3.2    8.1   8.6         30    5.0   0.1    3.9  5  TRL             TRL-like protein family
        3.9    7.7  10.0         63    3.8   0.0    4.8  5  PilN            Fimbrial assembly protein (PilN)
        5.7    7.3   9.3    1.9e+02    2.5   0.1    4.9  5  TAL_effector    TAL effector repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1   1.6e-05      0.02       3      27 ..      10      34 ..       8      35 .. 0.83
   2 ?   -1.1   0.0       1.9   2.4e+03       1      14 [.      64      77 ..      64      79 .. 0.77
   3 !   25.9   0.1   5.2e-09   6.7e-06       1      27 [.     107     133 ..     107     134 .. 0.96
   4 !   18.7   0.1   9.6e-07    0.0012       1      26 [.     163     187 ..     163     189 .. 0.89
   5 !   13.5   0.1   4.4e-05     0.056       1      24 [.     218     241 ..     218     245 .. 0.88
   6 !   20.1   0.0   3.7e-07   0.00047       1      27 [.     274     300 ..     274     301 .. 0.94

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.6e-05
                SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrvqv 27
                +P +v v+sn+++++aD++n+++++
  EFC35872.1 10 NPFSVFVSSNNEVFIADYNNQSIRK 34
                55566689**************986 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.9
                BSSEEEEEEETTTE CS
         NHL  1 fnyPhGvavdsnGd 14
                +n+P Gv v+s+  
  EFC35872.1 64 LNNPIGVFVSSMKK 77
                799***98887655 PP

  == domain 3  score: 25.9 bits;  conditional E-value: 5.2e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+ v v+sn+++y+aD++n+r+++
  EFC35872.1 107 LNYPRNVYVSSNNEVYIADFCNQRIRK 133
                 79***********************86 PP

  == domain 4  score: 18.7 bits;  conditional E-value: 9.6e-07
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n P+Gv v sn+++y+aD+ nh ++
  EFC35872.1 163 LNGPAGVFV-SNNEVYIADYSNHVIR 187
                 799******.8************665 PP

  == domain 5  score: 13.5 bits;  conditional E-value: 4.4e-05
                 BSSEEEEEEETTTEEEEEECCCTE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhr 24 
                 +++P+G+ v+sn+++y++D+ nh 
  EFC35872.1 218 LYNPSGTFVSSNNEVYISDCFNHV 241
                 689****************88885 PP

  == domain 6  score: 20.1 bits;  conditional E-value: 3.7e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P Gv v+s++++y++D+ nhr+++
  EFC35872.1 274 LYSPLGVFVSSDNEVYISDCFNHRIRK 300
                 689**********************97 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.0     0.023        30      42      69 ..      23      54 ..      12      58 .. 0.77
   2 ?    0.5   0.0      0.64   8.2e+02      48      67 ..      73      92 ..      65      95 .. 0.85
   3 !    8.0   0.0    0.0028       3.5      29      69 ..     114     150 ..     106     153 .. 0.82
   4 ?    2.0   0.0      0.21   2.7e+02      43      67 ..     179     203 ..     168     209 .. 0.78
   5 ?    4.2   0.0     0.043        55      41      68 ..     233     260 ..     224     265 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.023
  Linker_histone 42 f.ksllkkalkkgvekgelvqpkg...kGasG 69
                    f + + ++ ++k +++g +v + g   kG+sG
      EFC35872.1 23 FiADYNNQSIRKVLQNGNIVTIAGngdKGFSG 54
                    3367789***************9966666666 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.64
  Linker_histone 48 kalkkgvekgelvqpkgkGa 67
                    + +kk +++g++v + g+G 
      EFC35872.1 73 SSMKKILQNGTIVTIAGNGK 92
                    5789**********999885 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0028
  Linker_histone  29 yikakykvvdvskfksllkkalkkgvekgelvqpkgkGasG 69 
                     y++++++v     ++ ++++ ++k +++g ++ + g+G++G
      EFC35872.1 114 YVSSNNEV----YIADFCNQRIRKVLQNGNIITIAGNGTKG 150
                     55555554....56788*******************88887 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.21
  Linker_histone  43 ksllkkalkkgvekgelvqpkgkGa 67 
                     + + ++ ++k  ++g++v + g+G 
      EFC35872.1 179 ADYSNHVIRKISQNGTIVTIAGNGK 203
                     6677999*************99664 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.043
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGas 68 
                      ++  +++ ++k  ++g++v + g+G  
      EFC35872.1 233 YISDCFNHVIRKISQNGTIVTIAGNGKG 260
                     446679****************986633 PP

>> B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.1     0.002       2.6      29      58 ..      19      50 ..       2      73 .. 0.72
   2 ?    1.0   0.0      0.35   4.4e+02      36      56 ..      71      91 ..      55      95 .. 0.73
   3 ?    3.6   0.0     0.054        69      37      56 ..     128     147 ..     105     152 .. 0.77
   4 ?   -3.1   0.0       6.2     8e+03      38      56 ..     183     202 ..     174     205 .. 0.72
   5 ?   -3.4   0.0       7.7   9.9e+03      40      56 ..     241     258 ..     234     261 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.002
  B2-adapt-app_C 29 snnv.as.tspdaleekLqanniftiAkrgve 58
                    +n+v     + +++++ Lq+ ni+tiA  g++
      EFC35872.1 19 NNEVfIAdYNNQSIRKVLQNGNIVTIAGNGDK 50
                    44444455799****************65553 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.35
  B2-adapt-app_C 36 spdaleekLqanniftiAkrg 56
                     ++++++ Lq+  i+tiA  g
      EFC35872.1 71 FVSSMKKILQNGTIVTIAGNG 91
                    6789999***********554 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.054
  B2-adapt-app_C  37 pdaleekLqanniftiAkrg 56 
                      + +++ Lq+ ni+tiA  g
      EFC35872.1 128 NQRIRKVLQNGNIITIAGNG 147
                     5789999**********444 PP

  == domain 4  score: -3.1 bits;  conditional E-value: 6.2
  B2-adapt-app_C  38 daleekLqann.iftiAkrg 56 
                     + +++k+++n+ i+tiA  g
      EFC35872.1 183 NHVIRKISQNGtIVTIAGNG 202
                     55677777777799999444 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 7.7
  B2-adapt-app_C  40 leekLqann.iftiAkrg 56 
                     +++k+++n+ i+tiA  g
      EFC35872.1 241 VIRKISQNGtIVTIAGNG 258
                     667777777699999443 PP

>> ComGF  Putative Competence protein ComGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0     0.062        79      44      69 ..      17      41 ..       2      46 .. 0.66
   2 ?    0.6   0.0      0.59   7.6e+02      41      70 ..     113     141 ..      65     145 .. 0.70
   3 ?    5.1   0.0     0.023        29      47      69 ..     173     195 ..     169     200 .. 0.85
   4 ?    0.5   0.0      0.62     8e+02      46      69 ..     228     251 ..     214     256 .. 0.66
   5 ?   -1.9   0.0       3.5   4.5e+03      43      67 ..     282     304 ..     271     311 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.062
       ComGF 44 kkekktityekynnkirkrvnggGyq 69
                ++ ++++ +  ynn+ +++v ++G++
  EFC35872.1 17 SS-NNEVFIADYNNQSIRKVLQNGNI 41
                44.45555666666666666688876 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.59
       ComGF  41 lllkkekktityekynnkirkrvnggGyqp 70 
                 +++++++++++ +  n+ irk+  ++G+++
  EFC35872.1 113 VYVSSNNEVYIADFCNQRIRKVL-QNGNII 141
                 46777777777777777777665.777765 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.023
       ComGF  47 kktityekynnkirkrvnggGyq 69 
                 ++++++  y+n+ +++++++G++
  EFC35872.1 173 NNEVYIADYSNHVIRKISQNGTI 195
                 78999999999999999999976 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.62
       ComGF  46 ekktityekynnkirkrvnggGyq 69 
                  +++++++   n+ +++++++G++
  EFC35872.1 228 SNNEVYISDCFNHVIRKISQNGTI 251
                 455566666656666666777765 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 3.5
       ComGF  43 lkkekktityekynnkirkrvnggG 67 
                 +++++++++ +  n+ irk+   + 
  EFC35872.1 282 VSSDNEVYISDCFNHRIRKIS--NS 304
                 677888888888888888875..44 PP

>> HP1451_C  HP1451 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.49   6.3e+02       4      28 ..      19      43 ..      15      48 .. 0.84
   2 ?   -1.6   0.0       2.2   2.8e+03       4      29 ..     118     143 ..     117     148 .. 0.77
   3 ?    7.8   0.0    0.0025       3.2       1      29 [.     170     198 ..     170     203 .. 0.90
   4 ?    2.0   0.0      0.16   2.1e+02       4      29 ..     229     254 ..     225     259 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.49
                HHHHHHHHHHHHHHCCCCCTS-EEE CS
    HP1451_C  4 nQeemiesylksviekvkeegkaqt 28
                n e +i+ y ++ i+kv ++g++ t
  EFC35872.1 19 NNEVFIADYNNQSIRKVLQNGNIVT 43
                6788999************999988 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 2.2
                 HHHHHHHHHHHHHHCCCCCTS-EEEE CS
    HP1451_C   4 nQeemiesylksviekvkeegkaqtk 29 
                 n e  i+ + ++ i+kv ++g++ t 
  EFC35872.1 118 NNEVYIADFCNQRIRKVLQNGNIITI 143
                 56778888999999999999988875 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0025
                 HHHHHHHHHHHHHHHHHCCCCCTS-EEEE CS
    HP1451_C   1 FLknQeemiesylksviekvkeegkaqtk 29 
                 F+ n e  i+ y ++vi+k+ ++g + t 
  EFC35872.1 170 FVSNNEVYIADYSNHVIRKISQNGTIVTI 198
                 8999********************99885 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.16
                 HHHHHHHHHHHHHHCCCCCTS-EEEE CS
    HP1451_C   4 nQeemiesylksviekvkeegkaqtk 29 
                 n e  i+   ++vi+k+ ++g + t 
  EFC35872.1 229 NNEVYISDCFNHVIRKISQNGTIVTI 254
                 6677899999***********99885 PP

>> UNC-93  Ion channel regulatory protein UNC-93
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.3   4.1e-05     0.053      39      90 ..     288     342 ..     282     348 .] 0.81

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.1e-05
      UNC-93  39 GYyslaiiyavftvanlvapsvvd...lltakwalvigallyaifqlgFlllnky 90 
                  Y s ++ + +  ++n ++p + +   +++  + l+i+++++++f++gFl+l ++
  EFC35872.1 288 VYISDCFNHRIRKISNSFSPVLFEtfsKTSNPFNLTIASAFFSVFEMGFLQLLSI 342
                 5899999999999999999988751115677899*****************9776 PP

>> Plasmo_rep  Plasmodium repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.5     0.057        72       1      10 [.      17      26 ..      17      29 .. 0.84
   2 ?    5.7   0.1    0.0082        11       1       8 [.     116     123 ..     116     125 .. 0.86
   3 ?    5.0   0.2     0.014        18       2      10 ..     172     180 ..     172     186 .. 0.88
   4 ?   -3.3   0.0       5.4   6.9e+03      12      16 ..     188     192 ..     187     192 .. 0.86
   5 ?   -2.6   0.0       3.3   4.2e+03       3       9 ..     215     221 ..     215     221 .. 0.84
   6 ?    8.3   0.9    0.0013       1.7       1      10 [.     227     236 ..     227     248 .. 0.90
   7 ?   -3.0   0.0       4.5   5.7e+03       3       9 ..     271     277 ..     271     277 .. 0.83
   8 ?    8.7   0.4     0.001       1.3       1      10 [.     283     292 ..     283     292 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.057
  Plasmo_rep  1 FsDnEvYspk 10
                +s+nEv++ +
  EFC35872.1 17 SSNNEVFIAD 26
                69****9976 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0082
  Plasmo_rep   1 FsDnEvYs 8  
                 +s+nEvY+
  EFC35872.1 116 SSNNEVYI 123
                 69*****8 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.014
  Plasmo_rep   2 sDnEvYspk 10 
                 s+nEvY+ +
  EFC35872.1 172 SNNEVYIAD 180
                 9*****976 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 5.4
  Plasmo_rep  12 EieqN 16 
                 +i+qN
  EFC35872.1 188 KISQN 192
                 79**9 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 3.3
  Plasmo_rep   3 DnEvYsp 9  
                 + ++Y+p
  EFC35872.1 215 NAQLYNP 221
                 679**98 PP

  == domain 6  score: 8.3 bits;  conditional E-value: 0.0013
  Plasmo_rep   1 FsDnEvYspk 10 
                 +s+nEvY+++
  EFC35872.1 227 SSNNEVYISD 236
                 6*******98 PP

  == domain 7  score: -3.0 bits;  conditional E-value: 4.5
  Plasmo_rep   3 DnEvYsp 9  
                 + ++Ysp
  EFC35872.1 271 NAQLYSP 277
                 679**98 PP

  == domain 8  score: 8.7 bits;  conditional E-value: 0.001
  Plasmo_rep   1 FsDnEvYspk 10 
                 +sDnEvY+++
  EFC35872.1 283 SSDNEVYISD 292
                 6*******97 PP

>> Peptidase_A3  Cauliflower mosaic virus peptidase (A3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0       0.2   2.5e+02      50      71 ..      19      40 ..      10      48 .. 0.80
   2 ?    1.1   0.0      0.18   2.3e+02      49      72 ..     117     140 ..     104     147 .. 0.79
   3 ?    3.5   0.0     0.032        42      51      69 ..     174     192 ..     170     202 .. 0.81
   4 ?   -2.0   0.0       1.6   2.1e+03      51      69 ..     230     248 ..     222     257 .. 0.76
   5 ?   -2.2   0.0       1.9   2.5e+03      53     147 ..     288     302 ..     274     343 .. 0.62

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.2
  Peptidase_A3 50 Pkevkiadkskitiskvikdvd 71
                    ev iad  +  i+kv+++ +
    EFC35872.1 19 NNEVFIADYNNQSIRKVLQNGN 40
                  57899************99854 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.18
  Peptidase_A3  49 rPkevkiadkskitiskvikdvdl 72 
                      ev iad  +  i+kv+++ ++
    EFC35872.1 117 SNNEVYIADFCNQRIRKVLQNGNI 140
                   557899************998654 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.032
  Peptidase_A3  51 kevkiadkskitiskvikd 69 
                    ev iad s++ i+k+ ++
    EFC35872.1 174 NEVYIADYSNHVIRKISQN 192
                   5899***********9887 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.6
  Peptidase_A3  51 kevkiadkskitiskvikd 69 
                    ev i+d  ++ i+k+ ++
    EFC35872.1 230 NEVYISDCFNHVIRKISQN 248
                   6788999999999998776 PP

  == domain 5  score: -2.2 bits;  conditional E-value: 1.9
  Peptidase_A3  53 vkiadkskitiskvikdvdlkienkifliPivylqesGldliiGnnflklyePfiqflervilrkkklyPkeiaklsrkvlvktevlkeslkkrs 147
                   v i+d  ++ i+k+                                                                                s
    EFC35872.1 288 VYISDCFNHRIRKI--------------------------------------------------------------------------------S 302
                   44444444444443................................................................................2 PP

>> DUF4551  Protein of unknown function (DUF4551)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0    0.0092        12      34      72 ..       6      44 ..       4      45 .. 0.91
   2 ?   -1.6   0.0      0.71   9.1e+02      44      72 ..     115     143 ..     112     144 .. 0.88
   3 ?    2.2   0.0     0.051        65      43      72 ..     169     198 ..     167     199 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0092
     DUF4551 34 dsikkvfkyvvLsdelvYLtenpPrtlreavslrdvrsi 72
                 + ++ f+  v s++ v+++++  +++r++++ ++++ i
  EFC35872.1  6 AQLNNPFSVFVSSNNEVFIADYNNQSIRKVLQNGNIVTI 44
                5678899*************************9999987 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.71
     DUF4551  44 vLsdelvYLtenpPrtlreavslrdvrsi 72 
                 v s++ vY++++  + +r++++ +++  i
  EFC35872.1 115 VSSNNEVYIADFCNQRIRKVLQNGNIITI 143
                 66999***************999888876 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.051
     DUF4551  43 vvLsdelvYLtenpPrtlreavslrdvrsi 72 
                 v +s++ vY+++++  ++r++ + ++++ i
  EFC35872.1 169 VFVSNNEVYIADYSNHVIRKISQNGTIVTI 198
                 679*****************9999999887 PP

>> BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.17   2.2e+02     104     131 ..      81     108 ..      41     111 .. 0.86
   2 ?    6.4   0.1    0.0043       5.5     106     133 ..     139     166 ..      97     168 .. 0.85
   3 ?    1.0   0.0       0.2   2.5e+02     102     131 ..     190     219 ..     170     223 .. 0.79
   4 ?    1.1   0.0      0.18   2.3e+02     103     132 ..     247     276 ..     231     278 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.17
                  --EEEEEETTEEEEEEEETTEEEEEEEE CS
  BcrAD_BadFG 104 trtvldigGqdskgiqidkgkvenfqmn 131
                  + t++ i+G +  g++ d+g  +n q n
   EFC35872.1  81 NGTIVTIAGNGKPGFGGDNGLATNAQLN 108
                  339*****************99999987 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0043
                  EEEEEETTEEEEEEEETTEEEEEEEESS CS
  BcrAD_BadFG 106 tvldigGqdskgiqidkgkvenfqmndr 133
                   ++ i+G ++kg+  d+g  +n q n+ 
   EFC35872.1 139 NIITIAGNGTKGFSGDNGPATNAQLNGP 166
                  699*********************9985 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.2
                  TT--EEEEEETTEEEEEEEETTEEEEEEEE CS
  BcrAD_BadFG 102 pgtrtvldigGqdskgiqidkgkvenfqmn 131
                  +++ t++ i+G +  g+  d+g  +n q +
   EFC35872.1 190 SQNGTIVTIAGNGKPGFSGDNGLATNAQLY 219
                  3444****************9999998875 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.18
                  T--EEEEEETTEEEEEEEETTEEEEEEEES CS
  BcrAD_BadFG 103 gtrtvldigGqdskgiqidkgkvenfqmnd 132
                  ++ t++ i+G +  g+  d+g  +n q ++
   EFC35872.1 247 QNGTIVTIAGNGKGGFSGDNGPATNAQLYS 276
                  455******************999999875 PP

>> DPPIV_N  Dipeptidyl peptidase IV (DPP IV) N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.1   1.4e+03     332     352 ..      12      32 ..       4      47 .. 0.62
   2 ?    8.6   0.3   0.00054      0.69      12      93 ..     108     206 ..      99     227 .. 0.78
   3 ?   -0.7   0.0      0.37   4.7e+02      61      89 ..     228     256 ..     219     262 .. 0.78
   4 ?   -3.9   0.0       3.5   4.5e+03      61      80 ..     284     303 ..     276     312 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.1
                 EEEEE-TTSSEEEEEEESSSS CS
     DPPIV_N 332 ysasfspsgkyyvlkysgpdt 352
                 +s+ +s++ ++++  y+++++
  EFC35872.1  12 FSVFVSSNNEVFIADYNNQSI 32 
                 555666666666666655543 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00054
                 CEEEESSSEETTEEEEEETTTEECEEEETT.................TT.BSEEEEESSTTEEEEEETTEEEEESTTTSEEEECES-STTTEE..ESB- CS
     DPPIV_N  12 naeknwRhsytaeyyiydletneveelspg.................eeklqlakwSPagdklafvrnnnLyvrelatgkeiqlTsdgsagif..nGva 91 
                 n+ +n+  s+ +e+yi d+ +++++++ ++                 +++++ a++  +g + +fv nn++y+++ ++   ++++++g+ + +  nG++
  EFC35872.1 108 NYPRNVYVSSNNEVYIADFCNQRIRKVLQNgniitiagngtkgfsgdNGPATNAQL--NGPAGVFVSNNEVYIADYSNHVIRKISQNGTIVTIagNGKP 204
                 56667777888899999999988888888888888888888888766666666666..377779**************9*********44444346766 PP

                 -H CS
     DPPIV_N  92 dW 93 
                  +
  EFC35872.1 205 GF 206
                 65 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.37
                 ETTEEEEESTTTSEEEECES-STTTEEES CS
     DPPIV_N  61 rnnnLyvrelatgkeiqlTsdgsagifnG 89 
                  nn++y++++ +   ++++++g+ + ++G
  EFC35872.1 228 SNNEVYISDCFNHVIRKISQNGTIVTIAG 256
                 5788******9999999999996665555 PP

  == domain 4  score: -3.9 bits;  conditional E-value: 3.5
                 ETTEEEEESTTTSEEEECES CS
     DPPIV_N  61 rnnnLyvrelatgkeiqlTs 80 
                  +n++y++++ + + +++++
  EFC35872.1 284 SDNEVYISDCFNHRIRKISN 303
                 46777777777776666654 PP

>> TRL  TRL-like protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.1     0.024        30      33      54 ..      24      45 ..       3      46 .. 0.83
   2 ?   -3.3   0.1       9.1   1.2e+04      40      54 ..      74      88 ..      73      88 .. 0.82
   3 ?    4.9   0.0     0.024        31      27      54 ..     117     144 ..      97     146 .. 0.86
   4 ?    0.8   0.1      0.47   6.1e+02      29      54 ..     174     199 ..     153     200 .. 0.81
   5 ?   -1.8   0.0       3.1   3.9e+03      40      54 ..     241     255 ..     228     256 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.024
         TRL 33 lvstGdaSieaaaknggItkia 54
                +  + ++Si+++ +ng+I +ia
  EFC35872.1 24 IADYNNQSIRKVLQNGNIVTIA 45
                556789************9996 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 9.1
         TRL 40 SieaaaknggItkia 54
                S++++ +ng I +ia
  EFC35872.1 74 SMKKILQNGTIVTIA 88
                788999999998885 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.024
         TRL  27 aksiLglvstGdaSieaaaknggItkia 54 
                 +++  ++  + ++ i+++ +ng+I +ia
  EFC35872.1 117 SNNEVYIADFCNQRIRKVLQNGNIITIA 144
                 56677899999*************9996 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.47
         TRL  29 siLglvstGdaSieaaaknggItkia 54 
                 +  ++  + +  i+++++ng I +ia
  EFC35872.1 174 NEVYIADYSNHVIRKISQNGTIVTIA 199
                 5567777888999********99986 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 3.1
         TRL  40 SieaaaknggItkia 54 
                  i+++++ng I +ia
  EFC35872.1 241 VIRKISQNGTIVTIA 255
                 588999999998886 PP

>> PilN  Fimbrial assembly protein (PilN)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1      0.46   5.9e+02      16      31 ..      32      47 ..      29      50 .. 0.84
   2 ?    0.8   0.0      0.44   5.6e+02      18      31 ..      74      90 ..      64      92 .. 0.73
   3 ?   -0.4   0.1      0.98   1.3e+03      17      31 ..     132     146 ..     130     149 .. 0.83
   4 ?    3.8   0.0     0.049        63      16      31 ..     186     201 ..     183     204 .. 0.89
   5 ?    3.8   0.1     0.051        65      16      31 ..     242     257 ..     239     260 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.46
        PilN 16 ltsisqegnqltitGs 31
                + ++ q+gn +ti G+
  EFC35872.1 32 IRKVLQNGNIVTIAGN 47
                567789*********8 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.44
        PilN 18 sis...qegnqltitGs 31
                s++   q+g  +ti G+
  EFC35872.1 74 SMKkilQNGTIVTIAGN 90
                444444*********97 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.98
        PilN  17 tsisqegnqltitGs 31 
                  ++ q+gn +ti G+
  EFC35872.1 132 RKVLQNGNIITIAGN 146
                 56779*********8 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.049
        PilN  16 ltsisqegnqltitGs 31 
                 + +isq+g  +ti G+
  EFC35872.1 186 IRKISQNGTIVTIAGN 201
                 789************8 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.051
        PilN  16 ltsisqegnqltitGs 31 
                 + +isq+g  +ti G+
  EFC35872.1 242 IRKISQNGTIVTIAGN 257
                 789************8 PP

>> TAL_effector  TAL effector repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1      0.15   1.9e+02      26      33 .]      40      47 ..      33      47 .. 0.84
   2 ?    2.3   0.0      0.17   2.2e+02      26      33 .]      83      90 ..      79      90 .. 0.88
   3 ?   -0.3   0.1       1.1   1.4e+03      26      33 .]     139     146 ..     132     146 .. 0.84
   4 ?    2.0   0.1      0.21   2.7e+02      26      33 .]     194     201 ..     192     201 .. 0.90
   5 ?    2.0   0.1      0.21   2.7e+02      26      33 .]     250     257 ..     248     257 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.15
                  HHHHHHTS CS
  TAL_effector 26 dIVkIAgN 33
                   IV IAgN
    EFC35872.1 40 NIVTIAGN 47
                  7******9 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.17
                  HHHHHHTS CS
  TAL_effector 26 dIVkIAgN 33
                   IV IAgN
    EFC35872.1 83 TIVTIAGN 90
                  6******9 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 1.1
                   HHHHHHTS CS
  TAL_effector  26 dIVkIAgN 33 
                    I+ IAgN
    EFC35872.1 139 NIITIAGN 146
                   799****9 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.21
                   HHHHHHTS CS
  TAL_effector  26 dIVkIAgN 33 
                    IV IAgN
    EFC35872.1 194 TIVTIAGN 201
                   6******9 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.21
                   HHHHHHTS CS
  TAL_effector  26 dIVkIAgN 33 
                    IV IAgN
    EFC35872.1 250 TIVTIAGN 257
                   6******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       445  (0.0248201); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2194.49
//
Query:       EFC35873.1  [L=476]
Description: hypothetical protein NAEGRDRAFT_82336 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (476 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2158  (0.120364); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.81u 0.31s 00:00:01.12 Elapsed: 00:00:00.54
# Mc/sec: 2645.13
//
Query:       EFC35874.1  [L=107]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0017   18.7   0.0     0.0082   16.6   0.0    2.0  2  Ank_3     Ankyrin repeat
     0.0029   18.2   0.1     0.0035   17.9   0.1    1.2  1  Ank_2     Ankyrin repeats (3 copies)


Domain annotation for each model (and alignments):
>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.43   3.9e+03       5      14 ..      61      70 ..      53      71 .. 0.74
   2 !   16.6   0.0   9.2e-07    0.0082       2      30 ..      73     101 ..      72     102 .. 0.95

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.43
       Ank_3  5 pLhlAarsgn 14
                 Lhl + +++
  EFC35874.1 61 KLHLIINNNS 70
                5777777765 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 9.2e-07
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 Get+L++A++   +ei+++L + +++d+n
  EFC35874.1  73 GETILMTAVKESAHEIIELLTQVPNIDFN 101
                 9**************************99 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.1   3.9e-07    0.0035      33      80 ..      48     101 ..      30     104 .. 0.71

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 3.9e-07
       Ank_2  33 AakngnleivklLleh..adnd...grtpLhyAarsghleivklLlek.gadin 80 
                 A+  ++le++k L  h  ++n+   g+t+L+ A++++  ei++lL +  ++d+n
  EFC35874.1  48 AICDQDLETLKSLKLHliINNNsvlGETILMTAVKESAHEIIELLTQVpNIDFN 101
                 444556777777777777443334499999999988777999988854566666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (107 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.32s 00:00:00.80 Elapsed: 00:00:00.52
# Mc/sec: 623.98
//
Query:       EFC35875.1  [L=690]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00078   18.7   0.0     0.0035   16.6   0.0    2.1  2  Transposase_21  Transposase family tnp2


Domain annotation for each model (and alignments):
>> Transposase_21  Transposase family tnp2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.16   2.9e+03      47      67 ..      38      58 ..      19      69 .. 0.74
   2 !   16.6   0.0   1.9e-07    0.0035      26     157 ..     214     333 ..     191     349 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.16
  Transposase_21 47 ssysvWpvllipynlPPWlcl 67
                    +s s W    + +nl  W  l
      EFC35875.1 38 TSESEWSSTQVDFNLHHWNNL 58
                    57799999999****999866 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 1.9e-07
  Transposase_21  26 dprnvrlglatdGfnPfgsmsssysvWpvllipyn.lPPWlclkqsnfllsllipGpksPgk.didvylePlvddlkelweeGvetydalkeekf 118
                      ++ +  +l  dG+ Pf++  ++   +  +++++n + P    k++n++l  ++p  ++P+k di++ l+ +++dl  l +         +++++
      EFC35875.1 214 STKRLTGTLNGDGVSPFKKSLNN---FYNFIVQFNeMSPSDRKKSTNNFLWAILP--RKPDKiDIEIGLKVIMNDLNCLNS---------NQKNL 294
                     45556667999******964444...34567777658899988888888877765..6677659************99976.........899** PP

  Transposase_21 119 nlravllwtindfPalstlsGlstkgklacvtCkkntes 157
                     nl+ ++   i d Pa s +   + +g++ c  C+++ e 
      EFC35875.1 295 NLEMIIERVIADLPARSEILFFKRQGFYFCHLCNTKGED 333
                     **********************************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (690 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       699  (0.0389871); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 3891.92
//
Query:       EFC35876.1  [L=220]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.012   15.6   4.4      0.022   14.7   4.4    1.5  1  GerD      Spore germination GerD central core domain
      0.062   13.6   8.3      0.096   13.0   8.3    1.3  1  GEMIN8    Gemini of Cajal bodies-associated protein 8


Domain annotation for each model (and alignments):
>> GerD  Spore germination GerD central core domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   4.4   2.5e-06     0.022      33      73 ..      43      83 ..      10     102 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2.5e-06
        GerD 33 kfaealaksmkkenekllkdLmkDpeYqkmlleilkdpeme 73
                +  + la+s +k ++k  ++L k+p+Y  ++++++ +++m+
  EFC35876.1 43 RMDSYLAESEQKTEKKRKRQLEKEPTYDDEMMNVITNNQMK 83
                445678*********************************97 PP

>> GEMIN8  Gemini of Cajal bodies-associated protein 8
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   8.3   1.1e-05     0.096     102     160 ..      12      73 ..       2     106 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.1e-05
      GEMIN8 102 dqsivseeeeeses.ekevecdlsn.meiteelRqyfaeterHreErrrqqqldaerl..ddy 160
                 +++  +e+e e+++  ++v++d+++  e t+ +  y ae+e+   E++r+ ql+ e +  d+ 
  EFC35876.1  12 KTKNETETEPEDDDvSENVDEDMIErQEFTDRMDSYLAESEQK-TEKKRKRQLEKEPTydDEM 73 
                 333344444444444899*999987369*************95.6677779999998753333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1719  (0.0958782); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1408.36
//
Query:       EFC35877.1  [L=994]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.7e-08   34.4   2.7    1.2e-07   31.7   0.0    3.0  2  N6_N4_Mtase  DNA methylase
  ------ inclusion threshold ------
        9.9    6.4  11.8        1.4    9.2   3.3    3.0  3  PH_10        Pleckstrin homology domain


Domain annotation for each model (and alignments):
>> N6_N4_Mtase  DNA methylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7   0.0   1.3e-11   1.2e-07     166     229 ..     827     892 ..     702     894 .. 0.74
   2 ?   -2.9   4.2      0.51   4.5e+03      94     139 ..     927     952 ..     899     991 .. 0.44

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 1.3e-11
                  CHH..----SS---HHHHHHHHHHHS-TT-EEEETT-TTTHHHHHHHHTT-EEEEEESSHHHHHHH CS
  N6_N4_Mtase 166 gdt..kkkHpaqkPvallerlIklstkkgdivlDpFaGSGtTavaakelgrkfiGieieeeyvela 229
                  +d   +++ + qkP+ l+  l+  +++ ++ivlD   G+ tTavaa + gr++i+ e +   +e a
   EFC35877.1 827 KDSnsRECNKGQKPLSLISWLVYQFSNVDGIVLDLCSGTATTAVAAVSYGRNSISLESNHGQFEHA 892
                  22233444589***********************************************99888765 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.51
                  TCCS-B--EEEEEEEESSTT-..---GGGSSBSS-HHHHHHHHHH......C CS
  N6_N4_Mtase  94 nkdrltsthEyilvfsknkkyllkfnldaikvpyeekdklekrga......y 139
                   k++  +t+++    sk+                          +      +
   EFC35877.1 927 TKRKTAPTKKTPKKASKK--------------------------KktetplK 952
                  111111111111111111..........................11222342 PP

>> PH_10  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.7     0.053   4.8e+02      43      84 ..     220     264 ..     205     283 .. 0.71
   2 ?   -2.7   0.0      0.74   6.6e+03      22      42 ..     784     804 ..     774     838 .. 0.72
   3 ?    9.2   3.3   0.00015       1.4      23      77 ..     900     958 ..     885     984 .. 0.60

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.053
       PH_10  43 kkkksksssllkkkssssskkkktklqLKGrilisnvtevt...s 84 
                 +k+  + s+l+ kk+ ++s +++++   KG+   s++ +++   +
  EFC35877.1 220 SKETPSVSKLKIKKKPRASLTSSSSYVVKGSMSTSKIASIIvpkT 264
                 3555555556666666677999***************99986542 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.74
       PH_10  22 reyevyLFekillcvkevkee 42 
                  ++ +y +e+ llc+ + + +
  EFC35877.1 784 ANFGTYKYESFLLCFPNKQVN 804
                 567778888999998554443 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00015
       PH_10  23 eyevyLFekillcv.kevkee....kkkksksssllkkksssss.....kkkktklqLKGrilis 77 
                 e+e   Fe  ++c  +e ++e    kk  ++++   kk     +     kkkkt+  LKG+ + s
  EFC35877.1 900 EFEKVNFEPLVVCTvSE-DKEkkekKKSTKRKTAPTKK-----TpkkasKKKKTETPLKGSKMQS 958
                 55666688877776433.33322212222222222233.....13445699*********86555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (994 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1967  (0.109711); expected 358.6 (0.02)
Passed bias filter:                      639  (0.0356406); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.96u 0.35s 00:00:01.31 Elapsed: 00:00:00.51
# Mc/sec: 5815.00
//
Query:       EFC35878.1  [L=610]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.5e-07   30.7   9.0    4.8e-07   29.8   9.0    1.5  1  Zn_clus        Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
       0.48   10.9   5.2       0.16   12.4   1.5    2.1  2  Prot_inhib_II  Potato type II proteinase inhibitor family


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.8   9.0   5.3e-11   4.8e-07       2      38 ..     283     328 ..     282     330 .. 0.91

  Alignments for each domain:
  == domain 1  score: 29.8 bits;  conditional E-value: 5.3e-11
                 S-HHHHHCT---STSSSS.......-HHHHHCT..HHHCCCCTCCC CS
     Zn_clus   2 aCdnCrkkKvKCdakkPa.......CsnCkkln..leCtfysessk 38 
                 aC+nCrk ++KC   +P+       C++Ckk++   eC++y+ +++
  EFC35878.1 283 ACINCRKSHRKCKIYRPHfkdkgmpCGECKKRGipDECVYYEPKKR 328
                 9*************99999999999**************7777665 PP

>> Prot_inhib_II  Potato type II proteinase inhibitor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.5   1.8e-05      0.16      18      42 ..     274     298 ..     270     308 .. 0.86
   2 ?   -1.8   0.2      0.48   4.3e+03      28      42 ..     308     324 ..     299     326 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.8e-05
  Prot_inhib_II  18 ssgskklkqiCtnCcagkkgCklys 42 
                     +++ + + +C+nC + ++ Ck+y+
     EFC35878.1 274 PTDPSQARMACINCRKSHRKCKIYR 298
                    566777889***************7 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.48
  Prot_inhib_II  28 CtnCcagk..kgCklys 42 
                    C  C++     +C +y+
     EFC35878.1 308 CGECKKRGipDECVYYE 324
                    77777644478999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (610 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1500  (0.0836633); expected 358.6 (0.02)
Passed bias filter:                      501  (0.0279436); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.50
# Mc/sec: 3650.71
//
Query:       EFC35879.1  [L=295]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.2e-31  103.8   0.6    7.6e-05   22.5   0.0    7.5  7  LRR_6         Leucine Rich repeat
    1.3e-18   66.8  10.8    3.1e-05   24.3   0.0    4.8  6  LRR_4         Leucine Rich repeats (2 copies)
    3.1e-18   65.3   1.8    8.3e-06   25.5   0.0    4.2  4  LRR_8         Leucine rich repeat
    6.2e-10   38.2   0.1         10    7.1   0.0    7.6  8  LRR_1         Leucine Rich Repeat
     0.0046   16.8   0.1         25    4.7   0.0    4.3  5  DUF4347       Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
      0.027   14.5   0.1      0.065   13.3   0.1    1.6  1  Dynein_heavy  Dynein heavy chain region D6 P-loop domain
      0.091   13.0   3.7        5.9    7.2   0.0    3.9  4  DUF2097       Uncharacterized protein conserved in archaea (D
       0.16   12.0  12.1       0.61   10.1   0.1    5.7  8  ApoB100_C     Apolipoprotein B100 C terminal


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   7.1e-05      0.16       5      18 ..     134     147 ..     131     153 .. 0.88
   2 !   22.5   0.0   3.4e-08   7.6e-05       5      24 .]     158     177 ..     155     177 .. 0.92
   3 !   19.5   0.0   3.1e-07   0.00069       5      24 .]     182     201 ..     179     201 .. 0.92
   4 ?    2.1   0.0      0.11   2.5e+02       5      21 ..     206     221 ..     204     224 .. 0.74
   5 !   11.6   0.0   0.00011      0.24       5      23 ..     229     247 ..     226     248 .. 0.91
   6 !    9.2   0.0   0.00061       1.4       3      23 ..     251     271 ..     249     272 .. 0.89
   7 !   17.3   0.0   1.5e-06    0.0033       5      22 ..     277     294 ..     275     295 .] 0.91

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.1e-05
       LRR_6   5 LteLdLsgNdIgDe 18 
                 L +L++sgN+IgDe
  EFC35879.1 134 LISLNISGNGIGDE 147
                 679**********9 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 3.4e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s N+IgDeGa+ L+
  EFC35879.1 158 LTSLDISANQIGDEGAKYLS 177
                 9***************9885 PP

  == domain 3  score: 19.5 bits;  conditional E-value: 3.1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s N IgDeGa+ L+
  EFC35879.1 182 LTSLDISANLIGDEGAKYLS 201
                 9***************9885 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.11
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 L +L++  N+I DeGa+
  EFC35879.1 206 LISLNIGKNEI-DEGAK 221
                 66899999999.56666 PP

  == domain 5  score: 11.6 bits;  conditional E-value: 0.00011
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+s+ +++ eG++ +
  EFC35879.1 229 LTSLDISYTQVDVEGVKFI 247
                 9***************977 PP

  == domain 6  score: 9.2 bits;  conditional E-value: 0.00061
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 + Lt+L++ gN Ig eG++ +
  EFC35879.1 251 RQLTSLNICGNRIGIEGVKFI 271
                 569***************977 PP

  == domain 7  score: 17.3 bits;  conditional E-value: 1.5e-06
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 L++Ld+s+N Ig eGa+ 
  EFC35879.1 277 LKSLDISYNRIGVEGAKF 294
                 9***************85 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   0.0   1.4e-08   3.1e-05       1      38 [.     132     170 ..     132     174 .. 0.89
   2 !   22.2   0.1   6.2e-08   0.00014       1      38 [.     156     194 ..     156     197 .. 0.89
   3 !   14.1   0.2   2.1e-05     0.047       1      39 [.     180     216 ..     180     219 .. 0.85
   4 !   13.2   0.0   4.1e-05     0.091       1      36 [.     204     239 ..     204     246 .. 0.79
   5 !   14.5   0.0   1.6e-05     0.036       1      36 [.     227     263 ..     227     267 .. 0.81
   6 !   15.6   0.0   7.1e-06     0.016       2      36 ..     252     287 ..     251     291 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 1.4e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L++s+N + d +  + + +++L++Ld+s N +i+d
  EFC35879.1 132 KQLISLNISGNGIGDEEAkFISeMKQLTSLDISAN-QIGD 170
                 58*************99996655*********999.8876 PP

  == domain 2  score: 22.2 bits;  conditional E-value: 6.2e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+s Nq+ d +   l+ +++L++Ld+s N li+d
  EFC35879.1 156 KQLTSLDISANQIGDEGAkyLSEMKQLTSLDISAN-LIGD 194
                 58*******88****99998778*********998.8876 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 2.1e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++Ld+s N + d +   l+ +++L +L++  N     +
  EFC35879.1 180 KQLTSLDISANLIGDEGAkyLSEMKQLISLNIGKN----EI 216
                 58*******88****99998778*********667....44 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 4.1e-05
                 SS--EEE--SS---.E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLsgNnli 36 
                 ++L++L+++ N +      ++ +++L++Ld+s   ++
  EFC35879.1 204 KQLISLNIGKNEIDeGAKYISEMKQLTSLDISYT-QV 239
                 589***********44444556*********876.55 PP

  == domain 5  score: 14.5 bits;  conditional E-value: 1.6e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++Ld+s +q+   +  + + + +L++L++ gN +i
  EFC35879.1 227 KQLTSLDISYTQVDVEGVkFISeMRQLTSLNICGN-RI 263
                 58**********99655585555********9999.55 PP

  == domain 6  score: 15.6 bits;  conditional E-value: 7.1e-06
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnli 36 
                 +L++L++ +N++  i++  + +  ++Lk+Ld+s N +i
  EFC35879.1 252 QLTSLNICGNRIG-IEGvkFISeVKQLKSLDISYN-RI 287
                 69*********99.777675555*********999.55 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.55   1.2e+03       8      22 ..      49      63 ..      48      71 .. 0.79
   2 !   17.9   0.0   8.3e-07    0.0019      20      61 .]     127     168 ..     118     169 .. 0.87
   3 !   25.5   0.0   3.7e-09   8.3e-06       2      60 ..     181     238 ..     176     239 .. 0.96
   4 !   17.9   0.0   8.7e-07     0.002       1      37 [.     251     287 ..     251     289 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.55
                -TTS--SEE-TTSST CS
       LRR_8  8 LsnNrltslddeaFk 22
                +++  ++ +dd++F 
  EFC35879.1 49 ICFEIISMIDDSWFI 63
                67778999*****96 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 8.3e-07
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + + +++L +L++s N +   +++ +s +++L+sLd+s N++
  EFC35879.1 127 FISEMKQLISLNISGNGIGDEEAKFISEMKQLTSLDISANQI 168
                 445599**********************************97 PP

  == domain 3  score: 25.5 bits;  conditional E-value: 3.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +LtsLd+s N + + + +  + +++L +L+++ N+++   ++ +s +++L+sLd+s+++
  EFC35879.1 181 QLTSLDISANLIGDEGAKYLSEMKQLISLNIGKNEIDEG-AKYISEMKQLTSLDISYTQ 238
                 7*************************************9.7***************986 PP

  == domain 4  score: 17.9 bits;  conditional E-value: 8.7e-07
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37 
                 ++LtsL+++ Nr+   + ++ + +++Lk+Ld+s+N++
  EFC35879.1 251 RQLTSLNICGNRIGIEGVKFISEVKQLKSLDISYNRI 287
                 68***********9999999999************98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1         8   1.8e+04       7      14 ..      64      71 ..      62      75 .. 0.69
   2 ?    5.5   0.0     0.015        34       2      18 ..     134     150 ..     133     155 .. 0.79
   3 ?    4.2   0.0     0.041        91       1      20 [.     157     176 ..     157     179 .. 0.82
   4 ?    2.8   0.0      0.12   2.6e+02       1      20 [.     181     200 ..     181     203 .. 0.80
   5 ?    1.5   0.0      0.31     7e+02       2      15 ..     206     218 ..     205     226 .. 0.76
   6 ?    0.6   0.0      0.62   1.4e+03       1      10 [.     228     237 ..     228     247 .. 0.84
   7 ?    4.9   0.0     0.025        56       1      12 [.     252     263 ..     252     273 .. 0.83
   8 !    7.1   0.0    0.0045        10       1      13 [.     276     288 ..     276     294 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 8
       LRR_1  7 Lsnnpllg 14
                L+n+ l++
  EFC35879.1 64 LNNCTLIS 71
                67887755 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.015
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L +L++s+n +++ ++ 
  EFC35879.1 134 LISLNISGNGIGDEEAK 150
                 89*******99777665 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.041
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+s n++++ ++ ++
  EFC35879.1 157 QLTSLDISANQIGDEGAKYL 176
                 599********988877766 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+s n +++ ++ ++
  EFC35879.1 181 QLTSLDISANLIGDEGAKYL 200
                 599*****999988777666 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.31
       LRR_1   2 LrhLdLsnnpllgl 15 
                 L +L+++ n + + 
  EFC35879.1 206 LISLNIGKNEI-DE 218
                 899*****998.44 PP

  == domain 6  score: 0.6 bits;  conditional E-value: 0.62
       LRR_1   1 nLrhLdLsnn 10 
                 +L++Ld+s+ 
  EFC35879.1 228 QLTSLDISYT 237
                 599****975 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.025
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++++n++
  EFC35879.1 252 QLTSLNICGNRI 263
                 599*******98 PP

  == domain 8  score: 7.1 bits;  conditional E-value: 0.0045
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+s+n+++
  EFC35879.1 276 QLKSLDISYNRIG 288
                 59********984 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.011        25     103     125 ..     145     167 ..     130     171 .. 0.86
   2 ?    4.0   0.0     0.018        41     103     127 ..     169     191 ..     166     199 .. 0.87
   3 ?    0.0   0.0       0.3   6.7e+02     104     122 ..     217     235 ..     200     241 .. 0.85
   4 ?    1.1   0.0      0.14   3.2e+02     105     122 ..     242     259 ..     238     264 .. 0.87
   5 ?   -0.8   0.0      0.53   1.2e+03     104     121 ..     265     282 ..     245     288 .. 0.68

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.011
     DUF4347 103 geaGeafvekLaqltgadvaAst 125
                 g++  +f+++++qlt  d++A++
  EFC35879.1 145 GDEEAKFISEMKQLTSLDISANQ 167
                 677899*************9974 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.018
     DUF4347 103 geaGeafvekLaqltgadvaAstdl 127
                 g++G +++++++qlt  d++A+  l
  EFC35879.1 169 GDEGAKYLSEMKQLTSLDISAN--L 191
                 689****************996..5 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.3
     DUF4347 104 eaGeafvekLaqltgadva 122
                 ++G +++++++qlt  d++
  EFC35879.1 217 DEGAKYISEMKQLTSLDIS 235
                 68999999*****999986 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.14
     DUF4347 105 aGeafvekLaqltgadva 122
                 +G +f+++++qlt  ++ 
  EFC35879.1 242 EGVKFISEMRQLTSLNIC 259
                 79***********99985 PP

  == domain 5  score: -0.8 bits;  conditional E-value: 0.53
     DUF4347 104 eaGeafvekLaqltgadv 121
                  +G +f+++++ql   d+
  EFC35879.1 265 IEGVKFISEVKQLKSLDI 282
                 357888888888877776 PP

>> Dynein_heavy  Dynein heavy chain region D6 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   2.9e-05     0.065      52      96 ..      56     105 ..      47     113 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.9e-05
                   HHHT-EEEEE-GGG-.CCCHHHHHHH...........HHTT-EEEEEEES CS
  Dynein_heavy  52 akegsWvlLqNchla.pswlkeLekileel....eeklhssfRlwltsep 96 
                   + ++sW +L+Nc l+ +++ + +++  + +    ++ ++++ +l+l s+ 
    EFC35879.1  56 MIDDSWFILNNCTLIsKQFFNVIKERSKLAiqfkKKFTKKRVQLFLKSQF 105
                   5679**********98999999999854224555677778899**99875 PP

>> DUF2097  Uncharacterized protein conserved in archaea (DUF2097)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.3      0.59   1.3e+03      41      70 ..      29      58 ..      15      60 .. 0.73
   2 ?   -0.4   0.0      0.61   1.4e+03      18      40 ..      78     100 ..      67     128 .. 0.62
   3 ?    3.0   0.0     0.053   1.2e+02       8      35 ..     217     243 ..     211     261 .. 0.84
   4 ?    7.2   0.0    0.0026       5.9      16      35 ..     272     291 ..     265     292 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.59
     DUF2097 41 ekkeslrltlkldgelinqlvevdleeikd 70
                + +e+ +  +kl++e++++ + +++  + d
  EFC35879.1 29 NMEEKSKKVVKLEQEIFSDDICFEIISMID 58
                336777888999999999988888766666 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.61
     DUF2097  18 vkegdileisynrvfvpGevlsi 40 
                 +ke+ +l i + + f++ +v   
  EFC35879.1  78 IKERSKLAIQFKKKFTKKRVQLF 100
                 55555555555555555444333 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.053
     DUF2097   8 eelieYiknnvkegdileisynrvfvpG 35 
                 +e   Yi  ++k+   l+isy  v v+G
  EFC35879.1 217 DEGAKYI-SEMKQLTSLDISYTQVDVEG 243
                 6778899.789999**********9998 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0026
     DUF2097  16 nnvkegdileisynrvfvpG 35 
                  +vk+   l+isynr+ v+G
  EFC35879.1 272 SEVKQLKSLDISYNRIGVEG 291
                 68999***********9998 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.2   7.2e+03       7      22 ..       7      23 ..       6      26 .. 0.68
   2 ?   10.1   0.1   0.00027      0.61      10      32 ..     115     139 ..     113     141 .. 0.89
   3 ?    2.5   0.1     0.063   1.4e+02      17      32 ..     148     163 ..     142     168 .. 0.83
   4 ?   -1.7   0.0       1.3   2.9e+03      11      32 ..     166     187 ..     162     190 .. 0.78
   5 ?    1.6   0.1      0.12   2.7e+02      19      34 ..     198     213 ..     185     231 .. 0.82
   6 ?   -0.8   0.0      0.66   1.5e+03      19      32 ..     221     234 ..     215     253 .. 0.75
   7 ?   -0.8   0.0      0.66   1.5e+03      19      32 ..     245     258 ..     235     259 .. 0.87
   8 ?   -0.6   0.0      0.57   1.3e+03      19      32 ..     269     282 ..     268     285 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.2
   ApoB100_C  7 qefsd.qlsdyyEklia 22
                q+f + q++++ E + +
  EFC35879.1  7 QDFENhQFINSEEIFTN 23
                66654278888888766 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00027
   ApoB100_C  10 sdqlsdyyE..kliaeskrLiDLsI 32 
                 sd l+d++E  k+i+e k+Li L I
  EFC35879.1 115 SDWLLDSFEeaKFISEMKQLISLNI 139
                 788999999889***********98 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.063
   ApoB100_C  17 yEkliaeskrLiDLsI 32 
                   k+i+e k+L  L I
  EFC35879.1 148 EAKFISEMKQLTSLDI 163
                 569********98887 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 1.3
   ApoB100_C  11 dqlsdyyEkliaeskrLiDLsI 32 
                 +q+ d   k ++e k+L  L I
  EFC35879.1 166 NQIGDEGAKYLSEMKQLTSLDI 187
                 6777777788999999987776 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.12
   ApoB100_C  19 kliaeskrLiDLsIek 34 
                 k ++e k+Li L I k
  EFC35879.1 198 KYLSEMKQLISLNIGK 213
                 88999*****999965 PP

  == domain 6  score: -0.8 bits;  conditional E-value: 0.66
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k i+e k+L  L I
  EFC35879.1 221 KYISEMKQLTSLDI 234
                 67888888877766 PP

  == domain 7  score: -0.8 bits;  conditional E-value: 0.66
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e ++L  L I
  EFC35879.1 245 KFISEMRQLTSLNI 258
                 99****99988876 PP

  == domain 8  score: -0.6 bits;  conditional E-value: 0.57
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  L I
  EFC35879.1 269 KFISEVKQLKSLDI 282
                 8******9977766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       856  (0.0477439); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.42
# Mc/sec: 2087.90
//
Query:       EFC35880.1  [L=538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       924  (0.0515366); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.21s 00:00:00.66 Elapsed: 00:00:00.36
# Mc/sec: 4451.88
//
Query:       EFC35881.1  [L=422]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0053   16.5   0.1     0.0091   15.8   0.1    1.5  1  Met_10    Met-10+ like-protein
  ------ inclusion threshold ------
       0.17   11.2   0.0       0.27   10.6   0.0    1.3  1  PrmA      Ribosomal protein L11 methyltransferase (PrmA)


Domain annotation for each model (and alignments):
>> Met_10  Met-10+ like-protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.1     1e-06    0.0091     100     165 ..     202     269 ..     187     366 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1e-06
                 TT-EEEETT-TTTCCHHHCCHHTTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEE....EEES-GGG--- CS
      Met_10 100 egevVvdvfAGiGpfaipiakyskakrvlaidlnPesvkylkeniklNkvekvvk....pileDgrevir 165
                 +  ++vdv    G+++i  a    + +v++ +++P+ v+ +k+   lN+v+k v+    ++  D+r++i+
  EFC35881.1 202 KKCLIVDVGSHLGFYSIYPAL--LGCKVISYEIQPKMVEVIKSSASLNDVDKLVSvknlAVFRDARKYIQ 269
                 55678999999******9998..67889************************997222234567777665 PP

>> PrmA  Ribosomal protein L11 methyltransferase (PrmA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0     3e-05      0.27     161     217 ..     202     257 ..     182     283 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 3e-05
        PrmA 161 egeevlDvGtGSGiLaiaaakLgakkvvavDiDevAvkvakeNaelNkveakleval 217
                 ++  ++DvG   G  +i  a+Lg k v+ + i +  v+v k+ a+lN+v++ ++v++
  EFC35881.1 202 KKCLIVDVGSHLGFYSIYPALLGCK-VISYEIQPKMVEVIKSSASLNDVDKLVSVKN 257
                 344788*****************85.889**********************998854 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (422 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       774  (0.0431703); expected 358.6 (0.02)
Passed bias filter:                      606  (0.0338); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 2671.77
//
Query:       EFC35882.1  [L=290]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0002   21.6   0.0    0.00027   21.2   0.0    1.3  1  Acetyltransf_1   Acetyltransferase (GNAT) family
  ------ inclusion threshold ------
      0.042   13.9   0.2       0.14   12.2   0.1    1.8  2  Acetyltransf_9   Acetyltransferase (GNAT) domain
      0.049   13.6   0.4       0.12   12.3   0.4    1.6  1  Acetyltransf_10  Acetyltransferase (GNAT) domain


Domain annotation for each model (and alignments):
>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   4.4e-08   0.00027      56     117 .]     187     246 ..      96     246 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 4.4e-08
                     TSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHTTESEEEEEEETTEHHHHHHHHH.TTE CS
  Acetyltransf_1  56 ekggvayieslaVspeyrgkGlGsaLlealeerareegikkivlaveedndaairlYek.lGF 117
                      k++++ ++s  V   +r++ l++++le+ +e+a++ g+++ vl ve +   ++ lY k  GF
      EFC35882.1 187 KKKKTMKVCSAGVFAFARRMRLATRMLEKNLEYAKQLGYNE-VL-VECTGAYSQQLY-KsYGF 246
                     68899999999999***************************.77.7778999*****.66**9 PP

>> Acetyltransf_9  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.79   4.7e+03       6      26 ..      70      90 ..      66      98 .. 0.79
   2 ?   12.2   0.1   2.4e-05      0.14      69     126 ..     187     247 ..     182     248 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.79
                    -GGGHHHHHHHHHHHTT---- CS
  Acetyltransf_9  6 teedldevlellkyaFqdees 26
                    t+e +++v+  l+ +F++ee+
      EFC35882.1 70 TQEYVQQVAVALSVVFAQEEP 90
                    677888888888888888876 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 2.4e-05
                     EEEEEEEEEEEEE-CCGTTS-HHHHHHHHHHHHHHHTT--EEEE--...SSHHHHHTTT-E CS
  Acetyltransf_9  69 ktlkaagvtgVavapehrgrgvlskLlaraleemreegqplsllfP...ssipiYrrfGye 126
                     k+ k+  v++ +v +  r+  +++++l++ le++++ g++ +l      +s ++Y+++G++
      EFC35882.1 187 KKKKTMKVCSAGVFAFARRMRLATRMLEKNLEYAKQLGYNEVLVECtgaYSQQLYKSYGFN 247
                     667788899999***********************9876655444334699********96 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.4     2e-05      0.12      63     110 ..     203     250 ..     185     256 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2e-05
  Acetyltransf_10  63 yrgqGigkaLleaveeeaekdgikleltvnasp.yavpfYeklGFkavg 110
                      +r+  +++++le+ +e+a++ g++ e+ v+ +  y +++Y+++GF +  
       EFC35882.1 203 ARRMRLATRMLEKNLEYAKQLGYN-EVLVECTGaYSQQLYKSYGFNEKA 250
                      788889************999999.999999988***********9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (290 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1748.57
//
Query:       EFC35883.1  [L=201]
Description: hypothetical protein NAEGRDRAFT_76458 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.3e-19   69.9   2.7    3.6e-19   69.3   2.7    1.3  1  Voldacs          Regulator of volume decrease after cellular 
  ------ inclusion threshold ------
       0.15   13.0   1.9       0.46   11.4   1.1    2.1  2  Ribosomal_L18_c  Ribosomal L18 C-terminal region


Domain annotation for each model (and alignments):
>> Voldacs  Regulator of volume decrease after cellular swelling
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.3   2.7     4e-23   3.6e-19       2     120 ..      90     200 ..      89     201 .] 0.92

  Alignments for each domain:
  == domain 1  score: 69.3 bits;  conditional E-value: 4e-23
     Voldacs   2 dLyvtesrllwvsekansgisipypsIalHAiqrdkkdeqeepclyvqldeeldesdnkeseegededdneededeeessveltlvPknae...etild 97 
                 +Lyv++++ll+++    + ++i++++I++H++q     +q++ c+y+ql ++   +    ++e+++++++e+d++  es +e++++ + ++   e+i++
  EFC35883.1  90 HLYVMSEHLLLFNM--VHAYKIHFSDILMHGVQ-----KQPQICMYCQLACDTGVA----KDEKDESQMDEDDDEGFESVCEMIIQLQVQSsalEQIYN 177
                 8************8..89***************.....699********9977765....8999*************************96677889** PP

     Voldacs  98 nifealsacqelhpdpdeeddee 120
                 ++++a+s+ +e  p +d++dd+e
  EFC35883.1 178 QMYQAFSRAAENVPLSDMQDDDE 200
                 *****************888876 PP

>> Ribosomal_L18_c  Ribosomal L18 C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.56     5e+03      27      43 ..     106     122 ..     102     131 .. 0.81
   2 ?   11.4   1.1   5.2e-05      0.46      19      57 ..     146     184 ..     140     200 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.56
  Ribosomal_L18_c  27 kykkqFskyikkgiead 43 
                      +yk +Fs+ + +g++ +
       EFC35883.1 106 AYKIHFSDILMHGVQKQ 122
                      79999999999988765 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 5.2e-05
  Ribosomal_L18_c  19 eLkeedeekykkqFskyikkgieaddleelykkahaaIr 57 
                      ++ e+d+e +++  +  i+ ++++  le++y+++++a  
       EFC35883.1 146 QMDEDDDEGFESVCEMIIQLQVQSSALEQIYNQMYQAFS 184
                      799******************************999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (201 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1263  (0.0704445); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1220.31
//
Query:       EFC35884.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.18   11.4  11.2       0.31   10.6  11.2    1.4  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6  11.2   1.7e-05      0.31      36     118 ..     137     214 ..     104     229 .. 0.49

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 1.7e-05
       SR-25  36 sqsrkassasekeeerskekkkkkrrrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkake 118
                 +++rk s++s+ e+e++k     ++ +++ ss+sss+  +ss s+  +s ++      ++    ++ k+ k+++k +k+k++ 
  EFC35884.1 137 KRKRKISNVSSFESEKRKTSISSTTPPTTCSSNSSSIGNNSSLSTNVHSQQSF-----NNCIVISNPKHLKRRRKYQKRKNSA 214
                 34444455554444444444444444444444444444444444433333333.....2333333444444444444444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1391  (0.0775838); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1515.16
//
Query:       EFC35885.1  [L=566]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.064   13.8   7.8        5.8    7.5   1.4    5.0  6  PQQ_3          PQQ-like domain
        1.3    9.5  17.9       0.39   11.1   6.3    2.9  2  EGF_2          EGF-like domain


Domain annotation for each model (and alignments):
>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.38   3.4e+03      11      25 ..      86     100 ..      82     100 .. 0.87
   2 ?    4.0   0.0    0.0086        77      13      30 ..     209     226 ..     200     237 .. 0.79
   3 ?    7.5   1.4   0.00065       5.8       7      37 ..     333     363 ..     332     366 .. 0.88
   4 ?   -3.0   0.0       1.4   1.2e+04      22      32 ..     389     409 ..     384     411 .. 0.61
   5 ?    1.1   0.0     0.069   6.2e+02      12      40 .]     435     467 ..     426     467 .. 0.74
   6 ?   -2.5   0.0      0.94   8.4e+03      13      30 ..     488     510 ..     470     518 .. 0.48

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.38
       PQQ_3  11 gpvnsspavdgglvy 25 
                 g+vns +a+++ lvy
  EFC35885.1  86 GEVNSLVATAEKLVY 100
                 6899999*******9 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.0086
       PQQ_3  13 vnsspavdgglvyvgtgd 30 
                 ++ ++av++ ++y++ +d
  EFC35885.1 209 TTKGVAVVDSTLYISEYD 226
                 45778*********9885 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.00065
       PQQ_3   7 vqlpgpvnsspavdgglvyvgtgdGtlyAlD 37 
                 +q+ g v++   +++g++yv ++ G++y + 
  EFC35885.1 333 TQFTGGVYGDIDAYNGYIYVISSVGSIYKIR 363
                 788899999999****************875 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 1.4
       PQQ_3  22 glvyvgtg..........dGt 32 
                 g++ +g++          dG+
  EFC35885.1 389 GTILIGSHtavyrfegaqDGS 409
                 788888874444444444555 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.069
       PQQ_3  12 pvnsspavdggl..vyvgtg..dGtlyAlDaet 40 
                 +  s++a+++++  ++++++   G+++ l+a+t
  EFC35885.1 435 REISQVAMSDDYqrLFIADPhhLGGVTQLNAKT 467
                 556899***99555****997767777666665 PP

  == domain 6  score: -2.5 bits;  conditional E-value: 0.94
       PQQ_3  13 vnssp.....avdgglvyvgtgd 30 
                 +++s      a  + +v  g+g 
  EFC35885.1 488 TYCSIscnsvASNNPTVCSGSGS 510
                 33444444323344556656554 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   6.3   4.4e-05      0.39       6      32 .]     503     537 ..     498     537 .. 0.82
   2 ?    3.0   3.8     0.015   1.3e+02       8      21 ..     553     565 ..     547     566 .] 0.75

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 4.4e-05
       EGF_2   6 eiCgghGtCvnqcG..........qCdCdsgyqGktC 32 
                 + C+g G+C                CdC+ gy+G tC
  EFC35885.1 503 TVCSGSGSCT--AYlvnpsylgkpFCDCEYGYSGTTC 537
                 57*******9..5555688888555************ PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.015
       EGF_2   8 CgghGtCvnqc.GqC 21 
                 C+ hGtCv  + + C
  EFC35885.1 553 CKSHGTCV--GyNTC 565
                 *******9..52356 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (566 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       464  (0.0258799); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 3617.44
//
Query:       EFC35886.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00049   20.4   6.0    0.00049   20.4   6.0    8.6  5  EGF_2     EGF-like domain
  ------ inclusion threshold ------
      0.043   14.1   3.9      0.043   14.1   3.9    8.5 10  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   6.0   5.4e-08   0.00049       5      32 .]      14      43 ..      10      43 .. 0.86
   2 ?   -6.1   9.9         2   1.8e+04       7      18 ..      60      71 ..      47      99 .. 0.70
   3 ?  -20.1  23.8         2   1.8e+04      11      21 ..     119     127 ..      86     167 .. 0.74
   4 ?   -2.6   3.1      0.85   7.7e+03       1      17 [.     225     243 ..     225     248 .. 0.72
   5 ?   -5.6   6.9         2   1.8e+04       1       4 [.     272     275 ..     261     295 .. 0.53

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 5.4e-08
       EGF_2  5 deiCgghGtCvnqcGq..CdCdsgyqGktC 32
                +  C ++G C  + G+  C+C++g+ GktC
  EFC35886.1 14 NVVCENGGNCTFSKGVevCSCPPGFAGKTC 43
                678*******87889555************ PP

  == domain 2  score: -6.1 bits;  conditional E-value: 2
       EGF_2  7 iCgghGtCvnqc 18
                iC + G+C  +c
  EFC35886.1 60 ICDVSGVCTYEC 71
                566666665222 PP

  == domain 3  score: -20.1 bits;  conditional E-value: 2
       EGF_2  11 hGtCvnqcGqC 21 
                 +G+C   +  C
  EFC35886.1 119 DGVCS--NYAC 127
                 45554..3333 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 0.85
       EGF_2   1 Csas..deiCgghGtCvnq 17 
                 Cs+s  + +C  h  C+++
  EFC35886.1 225 CSNSfcKIECLSHTDCNKP 243
                 8888877889999888844 PP

  == domain 5  score: -5.6 bits;  conditional E-value: 2
       EGF_2   1 Csas 4  
                 Cs++
  EFC35886.1 272 CSEN 275
                 3333 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   3.9   4.8e-06     0.043       5      32 .]      15      42 ..      12      42 .. 0.88
   2 ?   -2.5   5.5      0.73   6.6e+03       1      22 [.      67      86 ..      44      87 .. 0.82
   3 ?    2.7   0.5     0.018   1.6e+02       9      23 ..      96     110 ..      94     116 .. 0.69
   4 ?    0.2   2.3      0.11   9.5e+02       1      12 [.     117     127 ..     117     139 .. 0.80
   5 ?   -2.0   0.9      0.53   4.8e+03       1      12 [.     150     165 ..     141     179 .. 0.62
   6 ?   -1.8   1.7      0.45     4e+03       6      23 ..     183     200 ..     176     200 .. 0.67
   7 ?   -3.1   0.6       1.1     1e+04       1       8 [.     217     227 ..     217     232 .. 0.70
   8 ?   -3.9   0.8         2   1.8e+04       1       7 [.     234     241 ..     234     244 .. 0.72
   9 ?   -4.9   4.7         2   1.8e+04       6      13 ..     272     280 ..     260     287 .. 0.56
  10 ?   -2.4   0.0      0.71   6.4e+03       8      13 ..     290     295 ..     289     298 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 4.8e-06
                T.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF  5 p.CsngGtCvdtgrggytCiCpeGytGkr 32
                  C ngG C  ++ g   C Cp+G++Gk+
  EFC35886.1 15 VvCENGGNCTFSK-GVEVCSCPPGFAGKT 42
                37*******9999.9999*********96 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.73
                GCSTTSTTT-EEEEETTTEEEE CS
         EGF  1 CspnpCsngGtCvdtgrggytC 22
                C+ + C+ +G C ++  g++ C
  EFC35886.1 67 CT-YECLSDGDCATVV-GRPMC 86
                54.6699999998888.88888 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.018
                 T-EEEEETTTEEEEE CS
         EGF   9 gGtCvdtgrggytCi 23 
                 gG+C+ +  ++ +Ci
  EFC35886.1  96 GGKCIAGCINDTSCI 110
                 566666666666664 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.11
                 GCSTTSTTT-EE CS
         EGF   1 CspnpCsngGtC 12 
                 C+++ Csn + C
  EFC35886.1 117 CNDGVCSNYA-C 127
                 8887799988.7 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 0.53
                 GCSTT.STTT-E...E CS
         EGF   1 Cspnp.CsngGt...C 12 
                 C+ n  Cs  G+   C
  EFC35886.1 150 CHVNSdCSDFGKysiC 165
                 4443346666665555 PP

  == domain 6  score: -1.8 bits;  conditional E-value: 0.45
                 STTT-EEEEET.TTEEEEE CS
         EGF   6 CsngGtCvdtg.rggytCi 23 
                 C n+  C   +  g+++C+
  EFC35886.1 183 CFNNSDC-ADPmTGTPRCD 200
                 7777777.33358888885 PP

  == domain 7  score: -3.1 bits;  conditional E-value: 1.1
                 GCSTT...STT CS
         EGF   1 Cspnp...Csn 8  
                 C ++    Csn
  EFC35886.1 217 CYSYGyslCSN 227
                 77777778887 PP

  == domain 8  score: -3.9 bits;  conditional E-value: 2
                 GCSTT.ST CS
         EGF   1 Cspnp.Cs 7  
                 C +++ C+
  EFC35886.1 234 CLSHTdCN 241
                 88877786 PP

  == domain 9  score: -4.9 bits;  conditional E-value: 2
                 STTT-E.EE CS
         EGF   6 CsngGt.Cv 13 
                 Cs + + C+
  EFC35886.1 272 CSENRItCL 280
                 444444343 PP

  == domain 10  score: -2.4 bits;  conditional E-value: 0.71
                 TT-EEE CS
         EGF   8 ngGtCv 13 
                 n G+Cv
  EFC35886.1 290 NLGKCV 295
                 899**5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       662  (0.0369234); expected 358.6 (0.02)
Passed bias filter:                      127  (0.0070835); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2169.80
//
Query:       EFC35887.1  [L=1705]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.7e-34  118.3   3.5    3.7e-34  118.3   3.5    3.5  4  REJ          REJ domain
    9.8e-05   22.3   0.6    9.8e-05   22.3   0.6    2.3  2  TMEM154      TMEM154 protein family
    0.00037   20.6  16.0    0.00037   20.6  16.0   11.8 11  Laminin_EGF  Laminin EGF domain
  ------ inclusion threshold ------
        1.8    7.9  12.1       0.16   11.3   6.4    2.2  2  DAG1         Dystroglycan (Dystrophin-associated glycoprotein


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.7   0.00015      0.68     101     213 ..     808     905 ..     788     920 .. 0.70
   2 !  118.3   3.5   8.2e-38   3.7e-34     152     417 ..    1050    1294 ..     964    1316 .. 0.80
   3 ?   -1.1   1.0      0.13     6e+02     251     427 ..    1382    1422 ..    1300    1439 .. 0.53
   4 ?   -4.0   0.8       1.1   4.7e+03     131     210 ..    1580    1598 ..    1531    1625 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00015
         REJ 101 ltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrs.rksasteqtilvv 198
                 ++Ld+s S   d+       l+++W++++               +  +  s++ +++++s +t+++++l  +  y +t t++      sas+++  lv+
  EFC35887.1 808 VYLDASGSTSTDRR-----TLQFSWSVQSAP----------SPLNGLTLTSLITNQQGSSGVTINSNSLGVG-SYSVTATITSPFsGLSASSTVSFLVT 890
                 67787777777655.....588888883333..........2222222333456777888888888888888.68888887665446688888888888 PP

         REJ 199 dgepplvsiecisnc 213
                 d   p+vsi+  s+ 
  EFC35887.1 891 DLTAPIVSIKEGSES 905
                 888888888876655 PP

  == domain 2  score: 118.3 bits;  conditional E-value: 8.2e-38
         REJ  152 gtllssstssltfpaselvanltynftltvskrsrksasteqtilvvd...gepplvsiecisncngk.vnpndrlvllasclncakdlkdvtfeWs 244 
                    + +  + +l+f ++ +v++  y ft t++k+sr s+s++  ++v d   + + +vsi  + n++ + v+p+++++l+a+++++   + d +++W 
  EFC35887.1 1050 SGEANIDQTTLKF-SKFMVPG-PYLFTATFTKGSR-SSSASIKVTVIDqpkDTVIRVSIAAPPNTDLTaVDPSSDFILQAYSSDVL--STDRVYTW- 1140
                  3333444445555.4445555.7************.8888888777652235678999*9999988652888899******99996..57888***. PP

         REJ  245 lsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaftvrC.qgwtD 340 
                            +pd   s  +t+++  ++ + +  L +g+   + l+v   +++ sg a+isf++n+pPt G ++v P +gval+++f+++C +gw D
  EFC35887.1 1141 ---------SSPDLDMSGIVTSNK--YILLPKILLVPGTFHIINLNV--VDDQRSGEATISFTINSPPTVGILEVSPATGVALQDDFQIKCgNGWYD 1224
                  .........455633666677766..*******************55..55555666**************************************** PP

         REJ  341 kdqPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarvsvsltitVkppavnns 417 
                   ++PL Ye++y+++ +s+ +++l+e s++ si + LP G+       +++  VyD+++a++++++ +tV+ p+ +++
  EFC35887.1 1225 TQLPLMYEFKYRVVGDST-WKVLSEMSEKKSITSQLPAGKI------EIKTIVYDSLSASSETTTLVTVTVPSLSEA 1294
                  ***************999.*********************9......9*************************9999 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.13
         REJ  251 eysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaftvrCqgwtDkdqPLgY 347 
                  + s++ d+++s+ +++++++++  k++  q+ ++ al l                                                          
  EFC35887.1 1382 TISKVIDQFSSTISSASSSSNVNMKTDDIQNSKEAALNL---------------------------------------------------------- 1420
                  223455555555555555555555555555555555555.......................................................... PP

         REJ  348 evsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarvsvsltitVkppavnnstieellenrt 427 
                                                                                                ++
  EFC35887.1 1421 ------------------------------------------------------------------------------KS 1422
                  ..............................................................................33 PP

  == domain 4  score: -4.0 bits;  conditional E-value: 1.1
         REJ  131 qpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrsrksasteqtilvvdgepplvsieci 210 
                  q ++++                                                             v+ +++ +s  c+
  EFC35887.1 1580 Q-ISCY------------------------------------------------------------SVQNNVYSISPNCK 1598
                  1.3333............................................................34444444444432 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.4       1.7   7.8e+03      18      47 ..    1388    1416 ..    1377    1424 .. 0.50
   2 !   22.3   0.6   2.2e-08   9.8e-05      17      88 ..    1619    1693 ..    1601    1700 .. 0.65

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.7
     TMEM154   18 eeesadatsaasteseslkqeeakeslssa 47  
                  +++s++ +sa s+ +  +k + ++++ ++a
  EFC35887.1 1388 DQFSSTISSASSSSNVNMK-TDDIQNSKEA 1416
                  3445555444444333333.4444444444 PP

  == domain 2  score: 22.3 bits;  conditional E-value: 2.2e-08
     TMEM154   17 leeesada.tsaasteseslkqeeakeslssaelsnesdqlelvlmi..iiPlvllillllvviiliqkkkrkrs 88  
                  + e++ d+  ++++++ ++ ++++++  ++ + +++ +++l  ++ +  iiP vlli++ ++v+i  ++kk+k++
  EFC35887.1 1619 VAEVTVDSpITPTNSTPKPTESNNNNIVTPIPGVNQSDSNLYYIIFVlaIIPIVLLIIVGILVCICCMIKKKKKR 1693
                  444444330233444344444445555667777877777777766543389**************9999888875 PP

>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.81   3.6e+03      15      24 ..       4      20 ..       2      27 .. 0.71
   2 ?  -10.2  17.0         4   1.8e+04       3      45 ..      39      86 ..      16      92 .. 0.77
   3 ?   -4.5   8.2         4   1.8e+04      11      38 ..     103     140 ..      88     148 .. 0.63
   4 ?   -8.6  11.1         4   1.8e+04      11      43 ..     164     207 ..     152     214 .. 0.59
   5 ?   -1.5  15.5      0.63   2.8e+03       3      33 ..     390     415 ..     357     429 .. 0.83
   6 ?   -4.8   7.9         4   1.8e+04       3      32 ..     429     453 ..     425     464 .. 0.82
   7 ?   -2.9   9.7       1.8   8.1e+03       3      32 ..     457     510 ..     455     525 .. 0.87
   8 ?    0.4  13.0      0.16   7.2e+02       3      38 ..     514     559 ..     513     574 .. 0.70
   9 ?   -4.5  13.7         4   1.8e+04      13      43 ..     568     604 ..     556     609 .. 0.64
  10 !   14.4  14.6   6.9e-06     0.031       3      41 ..     615     648 ..     603     652 .. 0.79
  11 !   20.6  16.0   8.2e-08   0.00037       1      42 [.     654     690 ..     654     696 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.81
                 T.......TTECESBTT CS
  Laminin_EGF 15 s.......stgqClCke 24
                 s       ++g+C C  
   EFC35887.1  4 StlkltldQNGKCVCDA 20
                 55555555799999975 PP

  == domain 2  score: -10.2 bits;  conditional E-value: 4
                 CCTTTBCCSSEET...TTECESBTTTEESTT....S-EE-TTEEEGTTSC CS
  Laminin_EGF  3 CnphgsssssCds...stgqClCkenveGrk....CdrCkpgyyglpsds 45
                 C+ +  s++ C+    +t  C Ck+++  ++    C  C +g ++   +s
   EFC35887.1 39 CPIACGSNGACQLltpTTSGCVCKNGFITTNetkpCSSCPQGKINS--SS 86
                 55555566788888889999****99865433344****9999987..33 PP

  == domain 3  score: -4.5 bits;  conditional E-value: 4
                  SSEET.......TTECESBTTT....EESTTS-EE-TTE CS
  Laminin_EGF  11 ssCds.......stgqClCken....veGrkCdrCkpgy 38 
                    Cd        s+g C+C+ n    + G+ C  Ck +y
   EFC35887.1 103 CGCDAsrgyiagSDGLCSCNANlnlvTYGSSC-VCKLNY 140
                  45666888888899999999984444457777.466555 PP

  == domain 4  score: -8.6 bits;  conditional E-value: 4
                  SSEET......TTECESBTTTEESTT.....S-EE-TTEEEGTT CS
  Laminin_EGF  11 ssCds......stgqClCkenveGrk.....CdrCkpgyyglps 43 
                  ++C            C+C  +++        C  C++ y ++++
   EFC35887.1 164 GQCMYedvnntARTICQCDTGYTTASystslCVDCARDYRMDKN 207
                  45555555555667799988876543233338888888887765 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 0.63
                  CCTTTBCCSSEETTTECESBTTTEESTTS-E CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCdr 33 
                  C+++g    +C + + +C+C++++ G++C++
   EFC35887.1 390 CSGRG----QCIQ-KDTCNCNNGYGGKNCEQ 415
                  44444....7877.899*************8 PP

  == domain 6  score: -4.8 bits;  conditional E-value: 4
                  CCTTTBCCSSEETTTECESBTTTEESTTS- CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCd 32 
                  Cn +g    +C     +C C+   +G++C+
   EFC35887.1 429 CNYRG----KCVG-PHTCACNGPWTGSDCQ 453
                  55555....7777.889************7 PP

  == domain 7  score: -2.9 bits;  conditional E-value: 1.8
                  CCTTTBCCSSEET.......................TTECES.BTTTEESTTS- CS
  Laminin_EGF   3 CnphgsssssCds.......................stgqCl.CkenveGrkCd 32 
                  Cn + ++++ C++                       s++ C+ C  +  G+ C+
   EFC35887.1 457 CNRKTEKQGGCNFngvcklilgspscicassgnwakSDVSCSvCATGWGGPGCN 510
                  88888888888888888888888888888899999999***************8 PP

  == domain 8  score: 0.4 bits;  conditional E-value: 0.16
                  CCTTTBCC.......SSEET...TTECESBTTTEESTTS-EE-TTE CS
  Laminin_EGF   3 Cnphgsss.......ssCds...stgqClCkenveGrkCdrCkpgy 38 
                  Cn+  s+s       + Cds    +  C C +++eG++C++ k + 
   EFC35887.1 514 CNGVISTSpdvcggrGGCDSirlAQPSCTCLKGYEGNNCQNFKCNE 559
                  666666666444444567779999999************9644444 PP

  == domain 9  score: -4.5 bits;  conditional E-value: 4
                  EET.....TTECESBTTTEESTT.S-EE-TTEEEGTT CS
  Laminin_EGF  13 Cds.....stgqClCkenveGrk.CdrCkpgyyglps 43 
                  C          +C Ck n++  k C +C p y g + 
   EFC35887.1 568 CSGrgtcaGLNTCVCKGNFDPAKfCSECTPAYNGTDC 604
                  433333333668******995544******9998743 PP

  == domain 10  score: 14.4 bits;  conditional E-value: 6.9e-06
                  CCTTTBCCSSEETTTECESBTTTEESTTS-EE-TTEEEG CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCdrCkpgyygl 41 
                  Cn++g     C+s +g+C+C  n  G+ Cd+C pg++g 
   EFC35887.1 615 CNGNG----ICNS-NGKCDCTGNWVGQFCDKCLPGFVGS 648
                  44444....7877.**********************987 PP

  == domain 11  score: 20.6 bits;  conditional E-value: 8.2e-08
                  S-CCTTTBCCSSEETTTECESBTTTEESTTS-EE-TTEEEGT CS
  Laminin_EGF   1 CeCnphgsssssCdsstgqClCkenveGrkCdrCkpgyyglp 42 
                  C+Cn++g    sC++ +g C C en eG+kC+ Ck g yg++
   EFC35887.1 654 CDCNGRG----SCNN-DGSCICSENAEGTKCETCKTGWYGDK 690
                  *******....**99.***********************985 PP

>> DAG1  Dystroglycan (Dystrophin-associated glycoprotein 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.3      0.71   3.2e+03      55      78 ..      68      91 ..      47      94 .. 0.79
   2 ?   11.3   6.4   3.6e-05      0.16      45     175 ..    1545    1691 ..    1502    1694 .. 0.58

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.71
                XXXXXXXXXXXXXXXXXXXXXXXX CS
        DAG1 55 tnntlklepcpkeqvaglskkild 78
                tn+t + ++cp+ +++  sk + d
  EFC35887.1 68 TNETKPCSSCPQGKINSSSKCVCD 91
                79999**********999988766 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 3.6e-05
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXX.......XXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXX CS
        DAG1   45 itkgsiiveftnntlklepcpkeqvaglskkildedgslreaf..kralePelkl.......tnisvvgssscrh...lefiplnqleeiPsevast 129 
                  it++   + f  + + l + + e+v++ +  +++ + s  ++   + ++ P+ k+       ++isv+ ++s      +   p++++++ P+++ s+
  EFC35887.1 1545 ITENDNNLSFASENITLATIKIEKVKTARTSFTQTQISCYSVQnnVYSISPNCKVvstnsatADISVTNTGSYVVaevTVDSPITPTNSTPKPTESN 1641
                  5555555555555556666666667666666666666654443003456666664111111134667666664431123334566666666555443 PP

                  X...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXX CS
        DAG1  130 e...apeedaeksseddvylhtvipavvvaailliagiiamicyr.kkrk 175 
                  +   ++  +   +s  + y + ++ a++ +++l+i gi++ ic   kk+k
  EFC35887.1 1642 NnniVTPIPGVNQSDSNLYYIIFVLAIIPIVLLIIVGILVCICCMiKKKK 1691
                  311134456678999***********************998887634443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1705 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1592  (0.0887947); expected 358.6 (0.02)
Passed bias filter:                      591  (0.0329634); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.23u 0.34s 00:00:01.57 Elapsed: 00:00:00.55
# Mc/sec: 9321.82
//
Query:       EFC35888.1  [L=295]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.2e-31  105.4   7.2    8.2e-07   28.8   0.0    6.0  6  NHL           NHL repeat
    2.2e-14   53.3   8.1    7.2e-06   25.4   0.5    3.7  4  DUF5128       6-bladed beta-propeller
    3.5e-10   39.9   0.9    1.9e-05   24.4   0.1    4.4  5  SGL           SMP-30/Gluconolactonase/LRE-like region
    6.7e-05   22.8   7.7     0.0065   16.4   0.2    4.3  5  SBBP          Beta-propeller repeat
     0.0014   18.5   0.5      0.016   15.1   0.0    2.8  4  DUF4934       Domain of unknown function (DUF4934)
     0.0027   17.9   0.9        5.4    7.3   0.0    4.4  5  Arylesterase  Arylesterase
  ------ inclusion threshold ------
      0.022   14.7   0.0        2.2    8.1   0.0    2.6  2  Phytase-like  Esterase-like activity of phytase


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.1   1.1e-08   2.8e-05       1      28 []      32      60 ..      32      60 .. 0.97
   2 ?   -1.6   0.0       1.3   3.5e+03       4      17 ..      77      90 ..      76      91 .. 0.85
   3 !   21.5   0.2   6.6e-08   0.00017       3      28 .]     122     147 ..     120     147 .. 0.96
   4 !   28.8   0.0   3.2e-10   8.2e-07       1      27 [.     167     193 ..     167     194 .. 0.97
   5 !   13.6   0.0     2e-05     0.052       1      28 []     214     242 ..     214     242 .. 0.95
   6 !   16.9   0.0   1.9e-06    0.0048       1      28 []     264     292 ..     264     292 .. 0.95

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1.1e-08
                BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL  1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28
                f +P++va+d +n  i+V D+ n r+qvF
  EFC35888.1 32 FKNPSDVAIDfKNQLIFVVDTDNRRIQVF 60
                789*************************9 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.3
                EEEEEEETTTEEEE CS
         NHL  4 PhGvavdsnGdiyV 17
                P+ v+v ++  +++
  EFC35888.1 77 PNAVTVHWDHTLII 90
                999***99999887 PP

  == domain 3  score: 21.5 bits;  conditional E-value: 6.6e-08
                 SEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqvF 28 
                 +P+Gv+vd  G+iyV+D   hr++vF
  EFC35888.1 122 SPTGVVVDYEGNIYVCDWFKHRIVVF 147
                 7************************9 PP

  == domain 4  score: 28.8 bits;  conditional E-value: 3.2e-10
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f++P+++ +ds G+i+++Ds+n+r+q+
  EFC35888.1 167 FSFPRDIDIDSAGNIIISDSGNNRIQI 193
                 89************************8 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 2e-05
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 f+ P++v vd s+Gdi+ ++  +hr+ +F
  EFC35888.1 214 FQAPNSVFVDkSTGDIFLTEWDSHRISKF 242
                 677999*********************99 PP

  == domain 6  score: 16.9 bits;  conditional E-value: 1.9e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 + yP+G+a +  + ++++ D++n+r++v+
  EFC35888.1 264 LKYPSGIAFCyGSSRLFIVDTGNNRIKVY 292
                 569************************98 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.1   1.8e-06    0.0047      88     147 ..      22      82 ..      17     106 .. 0.87
   2 !   25.4   0.5   2.8e-09   7.2e-06      56     122 ..     125     190 ..     114     191 .. 0.86
   3 !   20.3   0.5     1e-07   0.00026      63     120 ..     179     236 ..     177     246 .. 0.90
   4 ?   -1.2   0.0      0.33   8.6e+02      50      75 ..     262     289 ..     259     293 .. 0.67

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.8e-06
     DUF5128  88 IgaqGeGPgEYlqindfiidksnesIyildfmknkiltYdLegykfieekkldllvsdv.a 147
                 Ig+ G+  g + + +d +id +n+ I+++d  +++i ++d  ++ f++  + ++++++v +
  EFC35888.1  22 IGSYGSQNGQFKNPSDVAIDFKNQLIFVVDTDNRRIQVFDESTLTFKYMFTTPFKPNAVtV 82 
                 88999999**********************************************9976633 PP

  == domain 2  score: 25.4 bits;  conditional E-value: 2.8e-09
     DUF5128  56 skikvvdkrifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknk 122
                 + ++++++ i+v D+ k ++ vF+  G+  + Ig++G+  g +    d+ id    +I+i d+ +n+
  EFC35888.1 125 GVVVDYEGNIYVCDWFKHRIVVFSPGGELLKSIGSMGKEYGQFSFPRDIDIDSAG-NIIISDSGNNR 190
                 5678899*********************************************665.77778887776 PP

  == domain 3  score: 20.3 bits;  conditional E-value: 1e-07
     DUF5128  63 krifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmk 120
                 + i++ Ds +n++ +   +G+f++  g+ G+  gE+   n+ ++dks   I++ +   
  EFC35888.1 179 GNIIISDSGNNRIQILKSNGEFISSFGSIGNDKGEFQAPNSVFVDKSTGDIFLTEWDS 236
                 579************************************************9876555 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 0.33
     DUF5128  50 cligeiskikvvd..krifvlDsaknnl 75 
                 + ++++s i + +  +r+f++D+ +n++
  EFC35888.1 262 NSLKYPSGIAFCYgsSRLFIVDTGNNRI 289
                 5667777777666557888888887765 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0     0.089   2.3e+02     145     164 ..      44      63 ..      28     107 .. 0.57
   2 !   24.4   0.1   7.4e-09   1.9e-05     151     220 ..      91     157 ..      76     163 .. 0.70
   3 ?   -0.3   0.0      0.26   6.6e+02     191     217 ..     175     201 ..     170     206 .. 0.77
   4 !    5.2   0.0    0.0055        14     183     213 ..     213     245 ..     201     250 .. 0.84
   5 ?    3.2   0.0     0.022        58     130     163 ..     261     294 ..     252     295 .] 0.90

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.089
         SGL 145 gktlYlaDsltrkiwaydvd 164
                 ++ ++++D+ +r+i+++d +
  EFC35888.1  44 NQLIFVVDTDNRRIQVFDES 63 
                 33344444444444444432 PP

  == domain 2  score: 24.4 bits;  conditional E-value: 7.4e-09
         SGL 151 aDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfdpdGklieei 220
                   ++   i +yd++  ++ +      +++k+    p G++vD eGn++v+ w ++++v+f+p G+l++ i
  EFC35888.1  91 SFTRDSLICKYDFN-GNEIWRWGG--VTTKNVMDSPTGVVVDYEGNIYVCDWFKHRIVVFSPGGELLKSI 157
                 45556667777774.222233333..23444445699*****************************9977 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.26
         SGL 191 vDaeGnvwvAvwgggkvvrfdpdGkli 217
                 +D+ Gn+++   g+++++ ++ +G+ i
  EFC35888.1 175 IDSAGNIIISDSGNNRIQILKSNGEFI 201
                 688888888888888888888888766 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0055
         SGL 183 e.gepDGlavDa.eGnvwvAvwgggkvvrfdpd 213
                 e ++p +++vD+ +G ++ + w+++++++f p+
  EFC35888.1 213 EfQAPNSVFVDKsTGDIFLTEWDSHRISKFHPN 245
                 2456999*****9*****************997 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.022
         SGL 130 lddltipNGlawspdgktlYlaDsltrkiwaydv 163
                  ++l+ p G+a+   ++ l+++D+ +++i +y v
  EFC35888.1 261 ENSLKYPSGIAFCYGSSRLFIVDTGNNRIKVYRV 294
                 6789999***********************9986 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.89   2.3e+03      14      23 ..      34      43 ..      25      50 .. 0.76
   2 !   16.4   0.2   2.5e-06    0.0065      13      29 ..     121     137 ..     115     137 .. 0.91
   3 !    6.9   0.2    0.0024       6.2      14      26 ..     169     181 ..     166     183 .. 0.94
   4 ?   -2.8   0.0       2.7   6.9e+03      15      29 ..     217     232 ..     217     232 .. 0.66
   5 ?    0.2   0.0      0.31   7.9e+02       7      20 ..     258     272 ..     255     272 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.89
        SBBP 14 ygngIavDsn 23
                +++++a+D  
  EFC35888.1 34 NPSDVAIDFK 43
                7999***976 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 2.5e-06
        SBBP  13 tygngIavDsnGNiYvt 29 
                 ++++g+ vD +GNiYv+
  EFC35888.1 121 DSPTGVVVDYEGNIYVC 137
                 689************95 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0024
        SBBP  14 ygngIavDsnGNi 26 
                 ++++I +Ds GNi
  EFC35888.1 169 FPRDIDIDSAGNI 181
                 79**********8 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 2.7
        SBBP  15 gngIavDsnGN.iYvt 29 
                 +n++ vD++   i+ t
  EFC35888.1 217 PNSVFVDKSTGdIFLT 232
                 5777788776657765 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.31
        SBBP   7 Ggpgast.ygngIav 20 
                 G++++s+ y++gIa+
  EFC35888.1 258 GNHENSLkYPSGIAF 272
                 67777777*****96 PP

>> DUF4934  Domain of unknown function (DUF4934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.2   3.1e+03      68      86 ..      32      50 ..      12      66 .. 0.49
   2 ?   -0.4   0.0      0.44   1.1e+03      77      99 ..      85     106 ..      37     108 .. 0.58
   3 ?   -2.0   0.0       1.3   3.4e+03      51      63 ..     150     162 ..     126     168 .. 0.64
   4 !   15.1   0.0   6.1e-06     0.016      34      97 ..     180     245 ..     171     250 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.2
     DUF4934 68 ysevagwlndatgllyfsr 86
                +++ + +  d +++l f  
  EFC35888.1 32 FKNPSDVAIDFKNQLIFVV 50
                4444433333333333332 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.44
     DUF4934  77 datgllyfsrkpdklvkydakGe 99 
                 d+t +++f+r ++ + kyd +G+
  EFC35888.1  85 DHTLIISFTR-DSLICKYDFNGN 106
                 3344455554.445667777665 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1.3
     DUF4934  51 tGkflasvGhiGe 63 
                  G  l+s+G +G+
  EFC35888.1 150 GGELLKSIGSMGK 162
                 4777788887776 PP

  == domain 4  score: 15.1 bits;  conditional E-value: 6.1e-06
     DUF4934  34 dkivvsskkqCllfdketGkflasvGhiGedPegysev.agwlndatgllyfsrkpd.klvkydak 97 
                 + i+  s ++ +   k++G f++s G iG+d   ++   + +++++tg ++++++++ +++k++ +
  EFC35888.1 180 NIIISDSGNNRIQILKSNGEFISSFGSIGNDKGEFQAPnSVFVDKSTGDIFLTEWDShRISKFHPN 245
                 334444577888889****************99988874678999999999998875156676655 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.051   1.3e+02      52      81 ..      31      60 ..      25      64 .. 0.84
   2 !    7.3   0.0    0.0021       5.4      52      80 ..     119     146 ..     113     149 .. 0.86
   3 ?    0.6   0.0      0.25   6.5e+02      52      82 ..     166     195 ..     159     199 .. 0.84
   4 ?   -1.2   0.0      0.93   2.4e+03      53      78 ..     214     239 ..     209     243 .. 0.80
   5 ?    0.7   0.0      0.24   6.2e+02      51      83 ..     262     294 ..     257     295 .] 0.89

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.051
  Arylesterase 52 glssanGInidadkkyiyvadilresihvm 81
                  +++ +  + id +++ i+v d  ++ i v+
    EFC35888.1 31 QFKNPSDVAIDFKNQLIFVVDTDNRRIQVF 60
                  6889999*************9988888765 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0021
  Arylesterase  52 glssanGInidadkkyiyvadilresihv 80 
                    ++s++G+++d +   iyv d  ++ i v
    EFC35888.1 119 VMDSPTGVVVDYEG-NIYVCDWFKHRIVV 146
                   579********987.59********9977 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.25
  Arylesterase  52 glssanGInidadkkyiyvadilresihvmk 82 
                   ++s++  I id+   +i ++d+ ++ i ++k
    EFC35888.1 166 QFSFPRDIDIDSAGNII-ISDSGNNRIQILK 195
                   699*********99877.8898888888877 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 0.93
  Arylesterase  53 lssanGInidadkkyiyvadilresi 78 
                   ++++n + +d     i++++   + i
    EFC35888.1 214 FQAPNSVFVDKSTGDIFLTEWDSHRI 239
                   88899999999999999988777766 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.24
  Arylesterase  51 sglssanGInidadkkyiyvadilresihvmkk 83 
                   ++l+ + GI +      +++ d  ++ i v+++
    EFC35888.1 262 NSLKYPSGIAFCYGSSRLFIVDTGNNRIKVYRV 294
                   578999*****999999******9999999986 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.0   0.00088       2.2      18     104 ..      48     157 ..      31     164 .. 0.60
   2 ?    3.8   0.0     0.018        45      73     104 ..     173     204 ..     170     221 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00088
  Phytase-like  18 fyalsDrgs.k.nsarfytlkldldad.klgkveitevtplkdpd........................gapfpkkglD.pEgiavapdgtfwvssE 86 
                   f++ +D++  +    + +t+k+  ++  k ++v++   +                              g   +k+ +D p g++v+ +g+++v++ 
    EFC35888.1  48 FVVDTDNRRiQvFDESTLTFKYMFTTPfKPNAVTVHWDH-----TliisftrdslickydfngneiwrwGGVTTKNVMDsPTGVVVDYEGNIYVCDW 139
                   444466666544444555555555322333333333222.....233333444566666666666666633334555652569999*********** PP

  Phytase-like  87 ggpfilefdadGkllrel 104
                   ++++i+ f++ G+ll+++
    EFC35888.1 140 FKHRIVVFSPGGELLKSI 157
                   **************9987 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.018
  Phytase-like  73 iavapdgtfwvssEggpfilefdadGkllrel 104
                   i +++ g++++s+ g+++i   + +G++++++
    EFC35888.1 173 IDIDSAGNIIISDSGNNRIQILKSNGEFISSF 204
                   678899*********************99887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       343  (0.019131); expected 358.6 (0.02)
Passed bias filter:                      301  (0.0167884); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1687.65
//
Query:       EFC35889.1  [L=136]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       619  (0.0345251); expected 358.6 (0.02)
Passed bias filter:                      207  (0.0115455); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.24s 00:00:00.75 Elapsed: 00:00:00.50
# Mc/sec: 825.41
//
Query:       EFC35890.1  [L=754]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.1e-25   90.4   0.2    1.9e-25   89.6   0.2    1.4  1  Pkinase_Tyr  Protein tyrosine kinase
    9.7e-21   74.3   0.6    9.7e-21   74.3   0.6    1.6  2  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
          3    8.5  49.2       0.99   10.0   0.1    8.4  9  Chlam_PMP    Chlamydia polymorphic membrane protein (Chlamydi


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   89.6   0.2   3.2e-29   1.9e-25       4     127 ..     636     754 .]     633     754 .] 0.93

  Alignments for each domain:
  == domain 1  score: 89.6 bits;  conditional E-value: 3.2e-29
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTT..T CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkeke..k 99 
                  +kk+GeG  G V+ g+++      +  Va+K+lk e t++ ++e+ +ea+++++l+hpniv ++gv + +++ ++v+ey++ G+L+k++++ +++  +
   EFC35890.1 636 EKKIGEGGSGVVYLGKWH------HHPVAIKCLKIEDTAN-SDEIEKEAAMLCRLRHPNIVLFYGVSLTQHKQYLVVEYLERGSLEKYIQDMKRQeiS 726
                  689***************......99*******8877777.89**********************************************998555115 PP

                  SBHHHHHHHHHHHHHHHHHHHHTTEEES CS
  Pkinase_Tyr 100 ltlkdllsfalqvAkGmeyLeskklvHr 127
                  +t++++l++ +++A+Gm yL+s k++Hr
   EFC35890.1 727 VTFSEKLKLLIDIACGMVYLHSLKIIHR 754
                  6789***********************9 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1      0.49   2.9e+03      15      54 ..     570     607 ..     564     614 .. 0.75
   2 !   74.3   0.6   1.6e-24   9.7e-21       4     122 ..     636     754 .]     634     754 .] 0.94

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.49
                 EEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHH CS
     Pkinase  15 VykaveketgkivAvKkikkekakkkkekkvlrEikilkk 54 
                  y +v+ +++  + vK+ k ek+ +k+   + +Ei++++ 
  EFC35890.1 570 TYLCVKITRKVNYWVKRDKAEKDIEKRL--LENEITYMED 607
                 4888988888899999888887777665..8888888875 PP

  == domain 2  score: 74.3 bits;  conditional E-value: 1.6e-24
                 EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS--HH CS
     Pkinase   4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgslsee 98 
                 ++k+GeG++G+Vy ++  + ++ vA+K++k e++ +++e  + +E ++l +l+hpniv +y+v  ++++ ylv+ey+e g+l+++++    ++ s++ +
  EFC35890.1 636 EKKIGEGGSGVVYLGK--WHHHPVAIKCLKIEDTANSDE--IEKEAAMLCRLRHPNIVLFYGVSLTQHKQYLVVEYLERGSLEKYIQdmkrQEISVTFS 730
                 589************9..99************9999886..**********************************************998666778888 PP

                 HHHHHHHHHHHHHHHHHHTTEE-S CS
     Pkinase  99 eakkiakqilegleylHskgiiHr 122
                 e  k++  i+ g+ ylHs +iiHr
  EFC35890.1 731 EKLKLLIDIACGMVYLHSLKIIHR 754
                 99999******************9 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   1.4      0.23   1.4e+03       3      10 ..     125     132 ..     124     138 .. 0.83
   2 ?   -3.3   0.5         3   1.8e+04       3       9 ..     155     161 ..     154     163 .. 0.84
   3 ?    9.4   0.2   0.00027       1.6       2      25 ..     210     224 ..     209     225 .. 0.91
   4 ?    7.7   0.7   0.00091       5.4       2      26 ..     242     256 ..     241     257 .. 0.91
   5 ?   10.0   0.1   0.00017      0.99       4      28 .]     268     283 ..     267     283 .. 0.94
   6 ?    5.6   1.9    0.0041        25       2      25 ..     291     318 ..     290     320 .. 0.93
   7 ?    5.8   1.0    0.0036        21       3      25 ..     336     348 ..     335     351 .. 0.79
   8 ?   -3.9   0.4         3   1.8e+04      22      26 ..     372     376 ..     371     377 .. 0.86
   9 ?    1.0   0.0      0.12   7.5e+02       3      10 ..     394     401 ..     394     406 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.23
   Chlam_PMP   3 tFsnNtat 10 
                 +FsnN+++
  EFC35890.1 125 SFSNNHVN 132
                 8****995 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3
   Chlam_PMP   3 tFsnNta 9  
                  F nN a
  EFC35890.1 155 NFFNNIA 161
                 599**99 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00027
   Chlam_PMP   2 itFsnNtatvsstptpaaggGGAI 25 
                  +F++N++         +++GGA+
  EFC35890.1 210 SIFTDNKS---------YSKGGAL 224
                 69******.........******6 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.00091
   Chlam_PMP   2 itFsnNtatvsstptpaaggGGAIy 26 
                 ++Fs N++            GGAI+
  EFC35890.1 242 CSFSENSG----------EFGGAIH 256
                 89******..........******8 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00017
   Chlam_PMP   4 FsnNtatvsstptpaaggGGAIyae 28 
                 F +Nta           +GGAI+a+
  EFC35890.1 268 FYSNTA---------VQQGGAIFAK 283
                 899***.........9*******96 PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.0041
   Chlam_PMP   2 itFsnNtatvss....tptpaaggGGAI 25 
                 ++F nN++  +s    t ++  g+GGA 
  EFC35890.1 291 TYFINNSVIDTSltycTDNNCIGSGGAV 318
                 78*************************7 PP

  == domain 7  score: 5.8 bits;  conditional E-value: 0.0036
   Chlam_PMP   3 tFsnNtatvsstptpaaggGGAI 25 
                 +F +Nta            GG+I
  EFC35890.1 336 SFDGNTA----------TRGGGI 348
                 8******..........677776 PP

  == domain 8  score: -3.9 bits;  conditional E-value: 3
   Chlam_PMP  22 GGAIy 26 
                 GGA++
  EFC35890.1 372 GGALF 376
                 9**98 PP

  == domain 9  score: 1.0 bits;  conditional E-value: 0.12
   Chlam_PMP   3 tFsnNtat 10 
                 +FsnN++ 
  EFC35890.1 394 EFSNNQGL 401
                 6*****94 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (754 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       609  (0.0339673); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.47
# Mc/sec: 4787.33
//
Query:       EFC35891.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.073   13.5   0.1       0.11   13.0   0.1    1.3  1  FERM_M         FERM central domain
      0.092   12.6   0.1        0.2   11.5   0.1    1.5  1  DUF1381        Protein of unknown function (DUF1381)
        0.1   13.3   2.7       0.16   12.6   2.7    1.3  1  PLATZ          PLATZ transcription factor
       0.11   12.9   0.1       0.15   12.5   0.1    1.2  1  DUF668         Protein of unknown function (DUF668)
       0.43   10.6   3.4        3.5    7.7   0.3    2.5  2  zinc_ribbon_6  Zinc-ribbon
       0.47   11.3   5.8        1.1   10.1   5.8    1.6  1  Ntox50         Bacterial toxin 50


Domain annotation for each model (and alignments):
>> FERM_M  FERM central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   3.6e-05      0.11       8      78 ..      23      90 ..      17     105 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.6e-05
                HHHHHHHHHHHHHHHHTTSSXXXHHHHHHHHHHHHHHHHHHHHCXXXXXXXSSSXGGGSSXCHHHHHSXHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      FERM_M  8 evrinllYeQakwdllegeldcteeeallLAaLqlqiekgdlsesssekakeslnleeylpprlikklksk 78
                e  ++ lYeQ+++++ +++++ + +++++    q  +   + +  + ++ ++++n++++ +++ ++k k+k
  EFC35891.1 23 EWLREKLYEQLRNSIQTEKIKSEIKKYTKIRNCQTYTVVENSN--EVNEMSKEFNPKDV-SNERSRKTKNK 90
                567899************************9999999999977..45555555555543.33333344444 PP

>> DUF1381  Protein of unknown function (DUF1381)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   6.7e-05       0.2      19      37 ..      49      69 ..      46      74 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 6.7e-05
     DUF1381 19 FtAARDnqtFtvvEA..EskE 37
                +t  R+ qt+tvvE   E  E
  EFC35891.1 49 YTKIRNCQTYTVVENsnEVNE 69
                8999*********95224445 PP

>> PLATZ  PLATZ transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   2.7   5.3e-05      0.16      12      65 ..      44     107 ..      34     114 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 5.3e-05
       PLATZ  12 adieklldvseiQtYvi..nsakvvflnerpqarsakakakek.skkssse.......aCetCa 65 
                 ++i+k+  +++ QtY++  ns++v  +++  ++++ ++++++k ++k   e       +C+ C+
  EFC35891.1  44 SEIKKYTKIRNCQTYTVveNSNEVNEMSKEFNPKDVSNERSRKtKNKPIIEikksaglQCNNCN 107
                 689************8766899998888876666555555444333332224567788999997 PP

>> DUF668  Protein of unknown function (DUF668)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   5.1e-05      0.15      24      76 ..      17      70 ..       4      78 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.1e-05
      DUF668 24 rsssvpesardeLYqmLpasvrs.alrakLrslekkeavdellaaeikeeveki 76
                 s+ v+e  r++LY+ L +s+++ ++++ +++++k ++++  ++ e ++ev+++
  EFC35891.1 17 ISKDVHEWLREKLYEQLRNSIQTeKIKSEIKKYTKIRNCQTYTVVENSNEVNEM 70
                567788999************96379*********9999999999999998876 PP

>> zinc_ribbon_6  Zinc-ribbon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.2     0.029        86       4      32 ..      27      55 ..      26      64 .. 0.81
   2 ?    7.7   0.3    0.0012       3.5      46      56 ..      99     109 ..      95     112 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.029
  zinc_ribbon_6  4 eayfraldaeiaeqpmpeeyknkkvkilC 32
                   e+ +++l + i+ +++ +e+k+++    C
     EFC35891.1 27 EKLYEQLRNSIQTEKIKSEIKKYTKIRNC 55
                   5789999*********9999877654444 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0012
  zinc_ribbon_6  46 lglkCkeCgSY 56 
                    +gl+C++C+S+
     EFC35891.1  99 AGLQCNNCNSF 109
                    79********9 PP

>> Ntox50  Bacterial toxin 50
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   5.8   0.00036       1.1      10      71 ..      43     107 ..      24     115 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00036
      Ntox50  10 ikghknYeegk...Syllidskeaqellkkyagtgevvkdrkgkwrnkevvdfgevigvvvdket 71 
                 ++  k+Y++ +    y+++++++  + + k+++  +v+++r+ k +nk ++++++  g + ++ +
  EFC35891.1  43 KSEIKKYTKIRncqTYTVVENSNEVNEMSKEFNPKDVSNERSRKTKNKPIIEIKKSAGLQCNNCN 107
                 445567776555558888888888888888889999***********************999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2220  (0.123822); expected 358.6 (0.02)
Passed bias filter:                      777  (0.0433376); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 757.47
//
Query:       EFC35892.1  [L=556]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.035   13.7   0.0      0.077   12.6   0.0    1.5  1  DUF4218   Domain of unknown function (DUF4218)
      0.074   13.4   0.3       0.18   12.2   0.3    1.6  1  EZH2_N    EZH2 N-terminal domain


Domain annotation for each model (and alignments):
>> DUF4218  Domain of unknown function (DUF4218)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   8.6e-06     0.077      11      75 ..     444     508 ..     439     514 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 8.6e-06
     DUF4218  11 lekleeeiaitlcklEkiFppaffdvmvHLivHlvdeaklaGPvhyrnmypveRkllvlkkyvrn 75 
                 ++ ++ e++ +l ++Ek F  +  ++  H + H +d +  +GP+++ + + +e  + ++ ++++n
  EFC35892.1 444 IKLFDYEVSTLLQNVEKEFGSNCCTLATHSVKHFPDSIWNTGPLYATSTFVLEDAIGTIISTIKN 508
                 556677899999********************************************999999988 PP

>> EZH2_N  EZH2 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.3     2e-05      0.18      33      65 ..     359     391 ..     352     400 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2e-05
      EZH2_N  33 vPkYrFHhveikkniLspntmLkfvPHlRDled 65 
                 v  Y+ H  +i+kn+Ls nt+  +   +RDl +
  EFC35892.1 359 VVLYDRHLPDINKNLLSINTPSMYHRQVRDLSN 391
                 556999************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (556 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       612  (0.0341346); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 3464.83
//
Query:       EFC35893.1  [L=368]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      0.005   17.1   2.0       0.01   16.1   2.0    1.5  1  DUF4164          Domain of unknown function (DUF4164)
  ------ inclusion threshold ------
      0.019   15.1   3.3      0.039   14.0   3.3    1.5  1  Cep57_CLD_2      Centrosome localisation domain of PPC89
        7.1    7.3   8.5       0.93   10.2   2.9    2.2  2  YabA             Initiation control protein YabA
        9.1    6.5  13.0        0.4   10.9   5.3    2.3  2  TMF_TATA_bd      TATA element modulatory factor 1 TATA bindin


Domain annotation for each model (and alignments):
>> DUF4164  Domain of unknown function (DUF4164)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   2.0   2.3e-06      0.01      33      73 ..     192     232 ..     183     241 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 2.3e-06
     DUF4164  33 krdeleaeiealgedrsRLaeeLdqaearaarleevnrEvs 73 
                 +++++e++i++l ++r  La++ dq   ++ +l+++n+E+ 
  EFC35893.1 192 QQKKYEERIAQLVQERDELAQRTDQLVLECDTLKKLNEELV 232
                 56899**********************************86 PP

>> Cep57_CLD_2  Centrosome localisation domain of PPC89
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   3.3   8.8e-06     0.039      20      60 ..     194     234 ..     188     253 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 8.8e-06
  Cep57_CLD_2  20 qvheeelkrLnkERdsalrqLgvAyeelneLkaevealrkE 60 
                   ++ee +++L +ERd+ +++  +  +e++ Lk  +e l k 
   EFC35893.1 194 KKYEERIAQLVQERDELAQRTDQLVLECDTLKKLNEELVKS 234
                  689*********************************99765 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   2.9   0.00021      0.93      11      69 ..     194     252 ..     183     277 .. 0.63
   2 ?   -0.6   0.3      0.47   2.1e+03      33      57 ..     337     361 ..     308     368 .] 0.49

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00021
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXXXXXXXXXXXXXXXX CS
        YabA  11 eeleeqleelleeleelkeelaelleenaeLeleneklrerleeeekkekekkkelseg 69 
                 ++ ee++++l++e +el +++ +l+ e ++L+  ne+l +  +e++k++++ + + ++ 
  EFC35893.1 194 KKYEERIAQLVQERDELAQRTDQLVLECDTLKKLNEELVKSESEAKKRTSQVEFHFKQK 252
                 45677777777777777777777777777777777777666644444444443333333 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.47
                 HHHHHHHHHHHHHHHHHHHHXXXXX CS
        YabA  33 elleenaeLeleneklrerleeeek 57 
                 + +e+ +  +   ++ r++ +++++
  EFC35893.1 337 DAVEDQKVKKKRFDNYRQTRKKAQQ 361
                 3333333333333333333322222 PP

>> TMF_TATA_bd  TATA element modulatory factor 1 TATA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   5.3   8.8e-05       0.4      25      78 ..     190     243 ..     179     263 .. 0.83
   2 ?   -0.7   0.9      0.35   1.6e+03      52      81 ..     335     364 ..     319     366 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8.8e-05
  TMF_TATA_bd  25 EgElaslkeelerleaerdeareeivklmkeneelkelkkeleelekeleelqe 78 
                  E + ++++e++++l +erde+++   +l+ e+++lk+l++el + e+e ++ ++
   EFC35893.1 190 EFQQKKYEERIAQLVQERDELAQRTDQLVLECDTLKKLNEELVKSESEAKKRTS 243
                  566678899********************************9999998776544 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.35
  TMF_TATA_bd  52 lmkeneelkelkkeleelekeleelqerye 81 
                   +  +e++k +kk+ ++ ++  ++ q++ +
   EFC35893.1 335 TVDAVEDQKVKKKRFDNYRQTRKKAQQKNS 364
                  346788999999999999999999998865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (368 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1622  (0.090468); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 2238.79
//
Query:       EFC35894.1  [L=1080]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
          0 1138.0  63.1    2.6e-21   75.1   0.1   16.6 20  DUF4116         Domain of unknown function (DUF4116)
    1.2e-15   57.7   0.0    6.1e-15   55.3   0.0    2.2  2  Pkinase         Protein kinase domain
    3.4e-14   53.0   0.0        5.6    7.0   0.0    9.8 14  AfsA            A-factor biosynthesis hotdog domain
    3.9e-09   36.1  36.8       0.44    9.8   0.9   10.3 11  6PF2K           6-phosphofructo-2-kinase
    1.5e-05   24.4   0.0    5.6e-05   22.5   0.0    1.9  1  Pkinase_Tyr     Protein tyrosine kinase
    0.00025   21.2  15.0         24    5.1   0.0    9.6 11  DUF4853         Domain of unknown function (DUF4853)
  ------ inclusion threshold ------
      0.044   13.7  23.8         28    4.6   0.0    9.0 12  Kinase-PolyVal  Serine/Threonine/Tyrosine Kinase found in pol
      0.053   13.6   0.2    1.4e+02    2.6   0.0    4.9  3  P_C10           Protein C10
       0.21   11.2   0.6         97    2.6   0.0    4.8  5  DUF5551         Family of unknown function (DUF5551)
       0.52   11.5  16.1      2e+02    3.2   0.0    7.8  4  DUF2971         Protein of unknown function (DUF2971)
       0.83   10.2  37.9        4.8    7.7   0.6    8.8  8  AAA_18          AAA domain
        5.2    6.9   6.0    3.1e+02    1.2   0.0    4.9  2  CLTH            CTLH/CRA C-terminal to LisH motif domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.8   0.0   1.6e-22   2.4e-19       1      49 []     318     366 ..     318     366 .. 0.99
   2 !   68.6   0.0   1.8e-22   2.7e-19       1      49 []     343     391 ..     343     391 .. 0.99
   3 !   69.2   0.0   1.2e-22   1.8e-19       1      49 []     368     416 ..     368     416 .. 0.99
   4 !   75.1   0.1   1.8e-24   2.6e-21       1      49 []     393     441 ..     393     441 .. 0.99
   5 !   66.4   0.0   8.9e-22   1.3e-18       1      41 [.     418     458 ..     418     459 .. 0.98
   6 !   58.5   0.1   2.5e-19   3.8e-16       1      39 [.     443     481 ..     443     481 .. 0.99
   7 !   68.3   0.1   2.2e-22   3.3e-19       2      49 .]     482     529 ..     481     529 .. 0.98
   8 !   74.1   0.1   3.4e-24   5.1e-21       1      49 []     531     579 ..     531     579 .. 0.99
   9 !   65.4   0.1   1.8e-21   2.7e-18       1      49 []     556     604 ..     556     604 .. 0.99
  10 !   62.3   0.1   1.6e-20   2.5e-17       1      49 []     581     629 ..     581     629 .. 0.99
  11 !   73.1   0.0   7.2e-24   1.1e-20       1      49 []     606     654 ..     606     654 .. 0.99
  12 !   64.9   0.0   2.6e-21   3.9e-18       1      49 []     631     679 ..     631     679 .. 0.99
  13 !   54.0   0.4   6.6e-18   9.9e-15       1      49 []     656     704 ..     656     704 .. 0.99
  14 !   70.4   0.1     5e-23   7.5e-20       1      49 []     706     754 ..     706     754 .. 0.99
  15 !   55.6   0.1   2.1e-18   3.1e-15       3      49 .]     760     806 ..     759     806 .. 0.98
  16 !   62.3   0.0   1.8e-20   2.6e-17       1      49 []     808     856 ..     808     856 .. 0.99
  17 !   71.0   0.1   3.2e-23   4.8e-20       1      49 []     858     906 ..     858     906 .. 0.99
  18 !   66.7   0.1   7.1e-22   1.1e-18       1      49 []     908     956 ..     908     956 .. 0.99
  19 !   71.1   0.1     3e-23   4.5e-20       1      49 []     958    1006 ..     958    1006 .. 0.99
  20 !   70.2   0.1   5.7e-23   8.5e-20       1      49 []    1008    1056 ..    1008    1056 .. 0.99

  Alignments for each domain:
  == domain 1  score: 68.8 bits;  conditional E-value: 1.6e-22
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +rE+vleavk++g+a+ky++++L++D+eivl+A+kqng al+ya+e+Lr
  EFC35894.1 318 NREVVLEAVKQDGLAFKYADKSLRKDREIVLEAIKQNGRALEYADESLR 366
                 8**********************************************98 PP

  == domain 2  score: 68.6 bits;  conditional E-value: 1.8e-22
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivlea+k+ng al+y++e+L++D+eivl+A+kq+g+al ya+e+Lr
  EFC35894.1 343 DREIVLEAIKQNGRALEYADESLRKDREIVLEAIKQYGFALGYADESLR 391
                 9**********************************************98 PP

  == domain 3  score: 69.2 bits;  conditional E-value: 1.2e-22
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivlea+k++g+al y++e+L++D+eivl+A+kq+g+al+y++e+Lr
  EFC35894.1 368 DREIVLEAIKQYGFALGYADESLRKDREIVLEAIKQYGFALKYVDESLR 416
                 9**********************************************98 PP

  == domain 4  score: 75.1 bits;  conditional E-value: 1.8e-24
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivlea+k++g+alky++e+L++D+e+vl+Avkqng+al+y++e+Lr
  EFC35894.1 393 DREIVLEAIKQYGFALKYVDESLRKDREFVLEAVKQNGFALKYVDESLR 441
                 9**********************************************98 PP

  == domain 5  score: 66.4 bits;  conditional E-value: 8.9e-22
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 DrE+vleavk+ng+alky++e+L++D+eivl+Avkqng+al
  EFC35894.1 418 DREFVLEAVKQNGFALKYVDESLRKDREIVLEAVKQNGCAL 458
                 9**************************************99 PP

  == domain 6  score: 58.5 bits;  conditional E-value: 2.5e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 DrEivleavk+ng+al+ ++e+L++D+eivl+Avkqng+
  EFC35894.1 443 DREIVLEAVKQNGCALEDADESLRKDREIVLEAVKQNGY 481
                 9************************************97 PP

  == domain 7  score: 68.3 bits;  conditional E-value: 2.2e-22
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 rEivleavk+ng al+y++e+L++++e+vl+Avkqng+a++y++e+Lr
  EFC35894.1 482 REIVLEAVKQNGRALEYVDESLRKNREFVLEAVKQNGFAFKYVDESLR 529
                 9*********************************************98 PP

  == domain 8  score: 74.1 bits;  conditional E-value: 3.4e-24
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivleavk+ng+a+ky++e+L++Dk++vl+Avkqng+al+y++e+Lr
  EFC35894.1 531 DREIVLEAVKQNGFAFKYADESLRKDKQFVLEAVKQNGFALKYVDESLR 579
                 9**********************************************98 PP

  == domain 9  score: 65.4 bits;  conditional E-value: 1.8e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+++vleavk+ng+alky++e+L++Dkeivl+Avkqn  al+ a+e+Lr
  EFC35894.1 556 DKQFVLEAVKQNGFALKYVDESLRKDKEIVLEAVKQNRRALEDADESLR 604
                 9**********************************************98 PP

  == domain 10  score: 62.3 bits;  conditional E-value: 1.6e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eivleavk+n  al+ ++e+L++D+e+vl+A+kqng+al+y++e+Lr
  EFC35894.1 581 DKEIVLEAVKQNRRALEDADESLRKDREFVLEAIKQNGFALKYVDESLR 629
                 9**********************************************98 PP

  == domain 11  score: 73.1 bits;  conditional E-value: 7.2e-24
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vlea+k+ng+alky++e+L++D+e+vl+Avkq g+a++ya+e+Lr
  EFC35894.1 606 DREFVLEAIKQNGFALKYVDESLRKDREFVLEAVKQTGFAFKYADESLR 654
                 9**********************************************98 PP

  == domain 12  score: 64.9 bits;  conditional E-value: 2.6e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vleavk+ g+a+ky++e+L++Dkeivl+Avkqn  al+ a+e+Lr
  EFC35894.1 631 DREFVLEAVKQTGFAFKYADESLRKDKEIVLEAVKQNRRALEDADESLR 679
                 9**********************************************98 PP

  == domain 13  score: 54.0 bits;  conditional E-value: 6.6e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eivleavk+n  al+ ++e+L++D+eivl+A+kqn  al+ a+e+Lr
  EFC35894.1 656 DKEIVLEAVKQNRRALEDADESLRKDREIVLEAIKQNRRALEDADESLR 704
                 9**********************************************98 PP

  == domain 14  score: 70.4 bits;  conditional E-value: 5e-23
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vleavk+ng+al+ ++e+L++Dkeivl+Avkqn  al+ya+e+Lr
  EFC35894.1 706 DREFVLEAVKQNGCALEDADESLRKDKEIVLEAVKQNRRALEYADESLR 754
                 9**********************************************98 PP

  == domain 15  score: 55.6 bits;  conditional E-value: 2.1e-18
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +ivl ++k+n sal+ ++e L++D+e+vl+Avkqng+al+ya+++Lr
  EFC35894.1 760 QIVLAVIKQNISALEDADELLRKDREFVLEAVKQNGCALEYADNSLR 806
                 79*******************************************98 PP

  == domain 16  score: 62.3 bits;  conditional E-value: 1.8e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+vleavk+ng al+ ++++L++D+eivl+A+kqng al ya+++Lr
  EFC35894.1 808 DKEFVLEAVKQNGRALEDADNSLRKDREIVLEAIKQNGRALAYADNSLR 856
                 9*********************************************998 PP

  == domain 17  score: 71.0 bits;  conditional E-value: 3.2e-23
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+vleavk+ng+al+y++e L++D+eivl+Avkqng al+ya+++Lr
  EFC35894.1 858 DKEFVLEAVKQNGFALEYADELLRKDREIVLEAVKQNGRALEYADNSLR 906
                 9**********************************************98 PP

  == domain 18  score: 66.7 bits;  conditional E-value: 7.1e-22
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivlea+k++g+al+y++e L++D+eivl+Avkqng+al+ a+e+Lr
  EFC35894.1 908 DREIVLEAIKQYGFALEYADELLRKDREIVLEAVKQNGFALEDADESLR 956
                 9**********************************************98 PP

  == domain 19  score: 71.1 bits;  conditional E-value: 3e-23
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  D+Ei+leavk+ g+al+y++e L++D+eivl+A+kqng+al+y++e+Lr
  EFC35894.1  958 DKEIILEAVKQTGCALEYADELLRKDREIVLEAIKQNGCALKYVDESLR 1006
                  9**********************************************98 PP

  == domain 20  score: 70.2 bits;  conditional E-value: 5.7e-23
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  D+Ei+leavk+ g+alky++e+L++Dke+vl+Avkqn  al+ya+e+Lr
  EFC35894.1 1008 DKEIILEAVKQTGCALKYADESLRKDKEFVLEAVKQNRRALEYADESLR 1056
                  9**********************************************98 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.3   0.0   4.1e-18   6.1e-15      93     218 ..     130     278 ..     115     306 .. 0.79
   2 ?   -2.6   0.0       1.8   2.7e+03      69     113 ..     315     360 ..     276     361 .. 0.75

  Alignments for each domain:
  == domain 1  score: 55.3 bits;  conditional E-value: 4.1e-18
                 SS--HHHHHHHHHHHHHHHHHHH..HTTEE-SS-SGGGEEEE.TTTE........EEE-SGTTSEESSSSCS.................BCTTTSCGGG CS
     Pkinase  93 gslseeeakkiakqilegleylH..skgiiHrDlKpeNiLid.ekge........lKitDFGlakelesssk.................ltsfvgtseY 163
                 g+l  +ea +i+ +i+++l  lH  +++iiH D+Kp+Ni+i+ e             ++D+G+a+ ++s+s+                 + +  gt  Y
  EFC35894.1 130 GKLFLCEALQILIRIANALCRLHehKHNIIHSDIKPANIFISfE-PTiysfdvidAALGDLGIARTVSSKSQpiysstnifstpdtadtYLTHHGTCGY 227
                 45666788899999*****999944566**************55.334677787899*************99****************9999******* PP

                 S-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHH CS
     Pkinase 164 lAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilk 218
                 +APE  k+++    +DvWslG  ++ ll+ + + + +++ e v ++l++   i+k
  EFC35894.1 228 IAPECFKGEQC-VLSDVWSLGRAMLWLLFARKIDETQSHAE-VLMKLQE--DIQK 278
                 ******88776.679************99999988554444.3333333..2333 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.8
                 ESSEEEEEEE--TTEBHHHHHHHHSS--HHHHH.HHHHHHHHHHHH CS
     Pkinase  69 ekdelylvleyveggeladllerkgslseeeak.kiakqilegley 113
                 +kd++ +vle v+++ la  + +k+  +++e+  + +kq  ++ley
  EFC35894.1 315 SKDNREVVLEAVKQDGLAFKYADKSLRKDREIVlEAIKQNGRALEY 360
                 3788889999999999888887666655444443888888888888 PP

>> AfsA  A-factor biosynthesis hotdog domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.34     5e+02      26      79 ..     324     377 ..     313     391 .. 0.61
   2 ?    3.1   0.0     0.058        86      38      80 ..     361     403 ..     342     415 .. 0.77
   3 !    6.2   0.0    0.0064       9.6      48      92 ..     396     440 ..     383     462 .. 0.83
   4 ?   -0.6   0.0      0.81   1.2e+03      48      81 ..     446     479 ..     435     491 .. 0.85
   5 ?    0.1   0.0      0.49   7.4e+02      49      91 ..     485     527 ..     466     534 .. 0.91
   6 !    6.8   0.0    0.0041       6.2      40      98 ..     526     584 ..     502     603 .. 0.73
   7 !    7.0   0.0    0.0037       5.6      48     107 ..     609     668 ..     580     690 .. 0.77
   8 ?    3.2   0.0     0.056        83      48     104 ..     684     740 ..     657     770 .. 0.70
   9 ?    0.7   0.0      0.31   4.7e+02      49      81 ..     787     819 ..     777     830 .. 0.88
  10 ?    4.8   0.0     0.017        26      48      90 ..     836     878 ..     826     918 .. 0.79
  11 ?    0.6   0.0      0.34   5.1e+02      49      87 ..     912     950 ..     884     968 .. 0.58
  12 ?    1.8   0.0      0.15   2.3e+02      48      90 ..     936     978 ..     919     994 .. 0.82
  13 ?    0.1   0.0       0.5   7.5e+02      48      91 ..     961    1004 ..     950    1007 .. 0.82
  14 ?    4.4   0.0     0.023        34      48      87 ..    1011    1050 ..     997    1056 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.34
        AfsA  26 tarlprshefffdhesdhvdgllllEalRQaaiavaHtalgvpldtafildsls 79 
                 +a+ ++  +f ++++s + d  ++lEa+ Q + a+  +  ++  d++++l +++
  EFC35894.1 324 EAVKQDGLAFKYADKSLRKDREIVLEAIKQNGRALEYADESLRKDREIVLEAIK 377
                 445555556666666666666667777777776666666666666666665554 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.058
        AfsA  38 dhesdhvdgllllEalRQaaiavaHtalgvpldtafildslsl 80 
                 ++es + d  ++lEa+ Q ++a++ +  ++  d++++l +++ 
  EFC35894.1 361 ADESLRKDREIVLEAIKQYGFALGYADESLRKDREIVLEAIKQ 403
                 556666666689************99999**999999998765 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0064
        AfsA  48 lllEalRQaaiavaHtalgvpldtafildslslsfaafaeldvpv 92 
                 ++lEa+ Q ++a+     ++  d++f+l +++ + +a+ ++d+++
  EFC35894.1 396 IVLEAIKQYGFALKYVDESLRKDREFVLEAVKQNGFALKYVDESL 440
                 69******************************9999999998854 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 0.81
        AfsA  48 lllEalRQaaiavaHtalgvpldtafildslsls 81 
                 ++lEa+ Q + a+  +  ++  d++++l +++ +
  EFC35894.1 446 IVLEAVKQNGCALEDADESLRKDREIVLEAVKQN 479
                 589**********999999999999999998766 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.49
        AfsA  49 llEalRQaaiavaHtalgvpldtafildslslsfaafaeldvp 91 
                 +lEa+ Q + a+     ++   ++f+l +++ + +af ++d++
  EFC35894.1 485 VLEAVKQNGRALEYVDESLRKNREFVLEAVKQNGFAFKYVDES 527
                 8999999999999999999999******999999999999876 PP

  == domain 6  score: 6.8 bits;  conditional E-value: 0.0041
        AfsA  40 esdhvdgllllEalRQaaiavaHtalgvpldtafildslslsfaafaeldvpvvvrvev 98 
                 es + d  ++lEa+ Q ++a   +  ++  d++f+l +++ + +a+ ++d+++    e+
  EFC35894.1 526 ESLRKDREIVLEAVKQNGFAFKYADESLRKDKQFVLEAVKQNGFALKYVDESLRKDKEI 584
                 55566666789999999999999999999999999999999998888888855444444 PP

  == domain 7  score: 7.0 bits;  conditional E-value: 0.0037
        AfsA  48 lllEalRQaaiavaHtalgvpldtafildslslsfaafaeldvpvvvrvevsaseeeggr 107
                  +lEa+ Q ++a+     ++  d++f+l +++ + +af + d+++    e+  +++++ r
  EFC35894.1 609 FVLEAIKQNGFALKYVDESLRKDREFVLEAVKQTGFAFKYADESLRKDKEIVLEAVKQNR 668
                 689************999*************99999999999976665555555555444 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.056
        AfsA  48 lllEalRQaaiavaHtalgvpldtafildslslsfaafaeldvpvvvrvevsaseee 104
                 ++lEa+ Q   a+  +  ++  d++f+l +++ + +a++  d+++    e+  ++++
  EFC35894.1 684 IVLEAIKQNRRALEDADESLRKDREFVLEAVKQNGCALEDADESLRKDKEIVLEAVK 740
                 678888888888888888888888888888888877777777754444444333333 PP

  == domain 9  score: 0.7 bits;  conditional E-value: 0.31
        AfsA  49 llEalRQaaiavaHtalgvpldtafildslsls 81 
                 +lEa+ Q + a+  +  ++  d++f+l +++ +
  EFC35894.1 787 VLEAVKQNGCALEYADNSLRKDKEFVLEAVKQN 819
                 89***********99999*********998765 PP

  == domain 10  score: 4.8 bits;  conditional E-value: 0.017
        AfsA  48 lllEalRQaaiavaHtalgvpldtafildslslsfaafaeldv 90 
                 ++lEa+ Q + a+a +  ++  d++f+l +++ + +a+++ d+
  EFC35894.1 836 IVLEAIKQNGRALAYADNSLRKDKEFVLEAVKQNGFALEYADE 878
                 589***************************9999888888777 PP

  == domain 11  score: 0.6 bits;  conditional E-value: 0.34
        AfsA  49 llEalRQaaiavaHtalgvpldtafildslslsfaafae 87 
                 +lEa+ Q ++a+  +   +  d++++l +++ + +a++ 
  EFC35894.1 912 VLEAIKQYGFALEYADELLRKDREIVLEAVKQNGFALED 950
                 556666666655444444555555555555544433333 PP

  == domain 12  score: 1.8 bits;  conditional E-value: 0.15
        AfsA  48 lllEalRQaaiavaHtalgvpldtafildslslsfaafaeldv 90 
                 ++lEa+ Q ++a+  +  ++  d+++il +++ + +a+++ d+
  EFC35894.1 936 IVLEAVKQNGFALEDADESLRKDKEIILEAVKQTGCALEYADE 978
                 5899999999999999999999999999999887777776665 PP

  == domain 13  score: 0.1 bits;  conditional E-value: 0.5
        AfsA   48 lllEalRQaaiavaHtalgvpldtafildslslsfaafaeldvp 91  
                  ++lEa+ Q++ a+  +   +  d++++l +++ + +a+ ++d++
  EFC35894.1  961 IILEAVKQTGCALEYADELLRKDREIVLEAIKQNGCALKYVDES 1004
                  689******99998777669999999999999888888888765 PP

  == domain 14  score: 4.4 bits;  conditional E-value: 0.023
        AfsA   48 lllEalRQaaiavaHtalgvpldtafildslslsfaafae 87  
                  ++lEa+ Q++ a+  +  ++  d++f+l +++ +  a+++
  EFC35894.1 1011 IILEAVKQTGCALKYADESLRKDKEFVLEAVKQNRRALEY 1050
                  68***************************99987555555 PP

>> 6PF2K  6-phosphofructo-2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.2    0.0045       6.7     106     189 ..     338     421 ..     331     436 .. 0.80
   2 ?    3.5   0.0     0.025        38     107     147 ..     414     455 ..     411     460 .. 0.85
   3 !    8.7   0.0   0.00063      0.94     100     137 ..     457     494 ..     448     500 .. 0.87
   4 !    5.2   0.2    0.0079        12     108     160 ..     503     555 ..     499     586 .. 0.77
   5 ?    1.3   0.0      0.12   1.8e+02     106     147 ..     551     593 ..     546     598 .. 0.84
   6 !    9.8   0.9    0.0003      0.44     102     182 ..     597     677 ..     590     691 .. 0.84
   7 ?    4.1   0.2     0.017        25     102     156 ..     697     751 ..     683     759 .. 0.81
   8 ?    0.8   0.0      0.17   2.5e+02     102     145 ..     774     818 ..     757     822 .. 0.77
   9 !    8.0   0.3    0.0011       1.6     100     155 ..     822     877 ..     799     899 .. 0.83
  10 ?    2.1   0.0     0.066        98     104     154 ..     901     952 ..     897     968 .. 0.81
  11 !    7.3   0.7    0.0017       2.6     108     184 ..     980    1056 ..     968    1074 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0045
                 --SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHTTTSGGGTTS-HHHHHHHHHHHHHHHHTT-----TTTTTTSEE CS
       6PF2K 106 NttrerRklilefveennlkvlfl.esicsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsy 189
                  + r++R+++le +++n+    +  es+ +d+ei+ e ik+  +    Y+d++  +  +  l+ +++y  + + +d++  ++ ++
  EFC35894.1 338 KSLRKDREIVLEAIKQNGRALEYAdESLRKDREIVLEAIKQYGFA-LGYADESLRKDREIVLEAIKQYGFALKYVDESLRKDREF 421
                 567899999999999998554443389999999999999999999.899999999988888899999988888888776666655 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.025
                 -SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHT CS
       6PF2K 107 ttrerRklilefveennlkvlfl.esicsdeeiikeNikevk 147
                 + r++R+++le v++n++   ++ es+ +d+ei+ e +k+  
  EFC35894.1 414 SLRKDREFVLEAVKQNGFALKYVdESLRKDREIVLEAVKQNG 455
                 5699*************99888857999******99999876 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00063
                 EEEES---SHHHHHHHHHHHHHTT-EEEEEEEE--HHH CS
       6PF2K 100 aifDAtNttrerRklilefveennlkvlflesicsdee 137
                 a+ DA  + r++R+++le v++n+++ ++le++ ++ +
  EFC35894.1 457 ALEDADESLRKDREIVLEAVKQNGYREIVLEAVKQNGR 494
                 6679***************************9988765 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0079
                 SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHTTTSGGGTTS-HHH CS
       6PF2K 108 trerRklilefveennlkvlfl.esicsdeeiikeNikevklsspDYkdketee 160
                  r++R+++le v++n++   ++ es+ +d+ei+ e +k+  +    Y+d++  +
  EFC35894.1 503 LRKNREFVLEAVKQNGFAFKYVdESLRKDREIVLEAVKQNGFA-FKYADESLRK 555
                 6899999999999999888877578999999999999999988.7787776555 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.12
                 --SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHT CS
       6PF2K 106 NttrerRklilefveennlkvlfl.esicsdeeiikeNikevk 147
                  + r++++++le v++n++   ++ es+ +d+ei+ e +k+  
  EFC35894.1 551 ESLRKDKQFVLEAVKQNGFALKYVdESLRKDKEIVLEAVKQNR 593
                 57899*************99888857999******99998876 PP

  == domain 6  score: 9.8 bits;  conditional E-value: 0.0003
                 EES---SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHTTTSGGGTTS-HHHHHHHHHHHHHHHHTT-----TT CS
       6PF2K 102 fDAtNttrerRklilefveennlkvlfl.esicsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyepldde 182
                  DA  + r++R+++le +++n++   ++ es+ +d+e++ e +k+  +    Y+d++  +  +  l+ +++++++ e  d++
  EFC35894.1 597 EDADESLRKDREFVLEAIKQNGFALKYVdESLRKDREFVLEAVKQTGFA-FKYADESLRKDKEIVLEAVKQNRRALEDADES 677
                 59999*****************99888857999**************99.89999998888888888888887777777755 PP

  == domain 7  score: 4.1 bits;  conditional E-value: 0.017
                 EES---SHHHHHHHHHHHHHTT-EEE.EEEEE--HHHHHHHHHHHHTTTSGGGTTS CS
       6PF2K 102 fDAtNttrerRklilefveennlkvl.flesicsdeeiikeNikevklsspDYkdk 156
                  DA  + r++R+++le v++n++      es+ +d+ei+ e +k+       Y+d+
  EFC35894.1 697 EDADESLRKDREFVLEAVKQNGCALEdADESLRKDKEIVLEAVKQNRRA-LEYADE 751
                 59999****************9776524588899999999988887766.667665 PP

  == domain 8  score: 0.8 bits;  conditional E-value: 0.17
                 EES---SHHHHHHHHHHHHHTT-EEEEEE.EE--HHHHHHHHHHH CS
       6PF2K 102 fDAtNttrerRklilefveennlkvlfle.sicsdeeiikeNike 145
                  DA    r++R+++le v++n++   + + s+ +d+e++ e +k+
  EFC35894.1 774 EDADELLRKDREFVLEAVKQNGCALEYADnSLRKDKEFVLEAVKQ 818
                 588888999999999999999987766642566777777666665 PP

  == domain 9  score: 8.0 bits;  conditional E-value: 0.0011
                 EEEES---SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHTTTSGGGTT CS
       6PF2K 100 aifDAtNttrerRklilefveennlkvlfl.esicsdeeiikeNikevklsspDYkd 155
                 a+ DA N+ r++R+++le +++n+    +  +s+ +d+e++ e +k+  +    Y+d
  EFC35894.1 822 ALEDADNSLRKDREIVLEAIKQNGRALAYAdNSLRKDKEFVLEAVKQNGFA-LEYAD 877
                 667********************9777766257889999999999999888.67766 PP

  == domain 10  score: 2.1 bits;  conditional E-value: 0.066
                 S---SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHTTTSGGGT CS
       6PF2K 104 AtNttrerRklilefveennlkvlfl.esicsdeeiikeNikevklsspDYk 154
                 A N+ r++R+++le +++ ++   +  e + +d+ei+ e +k+  +  +D  
  EFC35894.1 901 ADNSLRKDREIVLEAIKQYGFALEYAdELLRKDREIVLEAVKQNGFALEDAD 952
                 779999*********9999988877624567899999999999888877754 PP

  == domain 11  score: 7.3 bits;  conditional E-value: 0.0017
                  SHHHHHHHHHHHHHTT-EEEEE.EEE--HHHHHHHHHHHHTTTSGGGTTS-HHHHHHHHHHHHHHHHTT-----TTTT CS
       6PF2K  108 trerRklilefveennlkvlfl.esicsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeed 184 
                   r++R+++le +++n++   ++ es+ +d+eii e +k+       Y+d++  +  +  l+ +++++++ e  d++  
  EFC35894.1  980 LRKDREIVLEAIKQNGCALKYVdESLRKDKEIILEAVKQTGCA-LKYADESLRKDKEFVLEAVKQNRRALEYADESLR 1056
                  589*************99988857999************9999.8999999888777777888888888887776543 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0   3.8e-08   5.6e-05      87     200 ..     120     256 ..     111     284 .. 0.69

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 3.8e-08
                  BHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEE........TTEEEE-STTTHEETTTSSEE..............E CS
  Pkinase_Tyr  87 dLlkfLrkkekekltlkdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlse........nkvvkisDfGLardiekddey..............v 160
                  d++k+ ++k + kl l + l++ + +A+++  L+++k  ++H d+   N+++s            + ++D G+ar+++++++                
   EFC35894.1 120 DMKKYGKNK-SGKLFLCEALQILIRIANALCRLHEHKhnIIHSDIKPANIFISFeptiysfdVIDAALGDLGIARTVSSKSQPiysstnifstpdtaD 216
                  667777777.99999999***************875434**************856666654445689*********777664323333332211111 PP

                  ETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHH.HHHHHHHT CS
  Pkinase_Tyr 161 kkeeaklpvkWmapEslkekkftsksDvWsfG.vllwEift 200
                  +  +++  + ++apE++k +++ + sDvWs G  +lw +f 
   EFC35894.1 217 TYLTHHGTCGYIAPECFKGEQC-VLSDVWSLGrAMLWLLFA 256
                  111223456799****998876.68*******445666665 PP

>> DUF4853  Domain of unknown function (DUF4853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.12   1.7e+02      66     108 ..     317     358 ..     311     361 .. 0.88
   2 ?    5.0   0.0     0.017        25      68     105 ..     394     430 ..     385     439 .. 0.86
   3 ?   -0.7   0.0      0.94   1.4e+03      68      99 ..     444     476 ..     437     485 .. 0.83
   4 ?    5.1   0.0     0.016        24      68     105 ..     532     568 ..     519     577 .. 0.85
   5 ?    1.8   0.0      0.17   2.5e+02      68      98 ..     607     637 ..     593     651 .. 0.86
   6 ?   -2.0   0.1       2.5   3.7e+03      68      97 ..     707     736 ..     682     744 .. 0.73
   7 ?   -0.4   0.0      0.78   1.2e+03      68     106 ..     784     821 ..     775     826 .. 0.85
   8 ?    0.2   0.0      0.52   7.8e+02      68     105 ..     834     870 ..     826     878 .. 0.85
   9 ?    1.7   0.0      0.17   2.6e+02      66     102 ..     907     943 ..     889     950 .. 0.78
  10 ?    1.4   0.0      0.22   3.2e+02      68      97 ..     934     963 ..     930     975 .. 0.85
  11 ?   -1.1   0.0       1.3   1.9e+03      68      97 ..     984    1013 ..     980    1044 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.12
                 HHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EE CS
     DUF4853  66 dlrevveeelkplGfkysekpderdkdesrtvvwgderyGgsl 108
                 d revv e++k++G++++  ++  +kd + ++ +  + +G  l
  EFC35894.1 317 DNREVVLEAVKQDGLAFKYADKSLRKDREIVLEAIKQ-NGRAL 358
                 6699*************************99988887.77766 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.017
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyG 105
                 re+v e++k++Gf+++  ++  +kd ++++ +  + +G
  EFC35894.1 394 REIVLEAIKQYGFALKYVDESLRKDREFVLEAVKQ-NG 430
                 89**************************9965555.55 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.94
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEE.EE CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtv.vw 99 
                 re+v e++k++G +++  ++  +kd + ++ ++
  EFC35894.1 444 REIVLEAVKQNGCALEDADESLRKDREIVLeAV 476
                 89999***********99999999999988444 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.016
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyG 105
                 re+v e++k++Gf+++  ++  +kd+++++ +  + +G
  EFC35894.1 532 REIVLEAVKQNGFAFKYADESLRKDKQFVLEAVKQ-NG 568
                 89**************************9966555.55 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.17
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEE CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvv 98 
                 re v e++k++Gf+++  ++  +kd ++++ 
  EFC35894.1 607 REFVLEAIKQNGFALKYVDESLRKDREFVLE 637
                 7889999********************9884 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 2.5
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEE CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtv 97 
                 re v e++k++G +++  ++  +kd++ ++
  EFC35894.1 707 REFVLEAVKQNGCALEDADESLRKDKEIVL 736
                 667777888888888888888888887766 PP

  == domain 7  score: -0.4 bits;  conditional E-value: 0.78
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS- CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyGg 106
                 re v e++k++G +++  +   +kd+++++ +  + +G 
  EFC35894.1 784 REFVLEAVKQNGCALEYADNSLRKDKEFVLEAVKQ-NGR 821
                 77888999********************9966666.665 PP

  == domain 8  score: 0.2 bits;  conditional E-value: 0.52
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyG 105
                 re+v e++k++G ++   +   +kd+++++ +  + +G
  EFC35894.1 834 REIVLEAIKQNGRALAYADNSLRKDKEFVLEAVKQ-NG 870
                 899*************************9966555.56 PP

  == domain 9  score: 1.7 bits;  conditional E-value: 0.17
                 HHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET CS
     DUF4853  66 dlrevveeelkplGfkysekpderdkdesrtvvwgde 102
                 + re+v e++k++Gf+++  ++  +kd + ++ +  +
  EFC35894.1 907 KDREIVLEAIKQYGFALEYADELLRKDREIVLEAVKQ 943
                 5599*************99999999999988854444 PP

  == domain 10  score: 1.4 bits;  conditional E-value: 0.22
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEE CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtv 97 
                 re+v e++k++Gf+++  ++  +kd++  +
  EFC35894.1 934 REIVLEAVKQNGFALEDADESLRKDKEIIL 963
                 899**************9999999998765 PP

  == domain 11  score: -1.1 bits;  conditional E-value: 1.3
                  HHHHHHT.--TTEEEEEE-SS--TTS-EEE CS
     DUF4853   68 revveeelkplGfkysekpderdkdesrtv 97  
                  re+v e++k++G +++  ++  +kd++  +
  EFC35894.1  984 REIVLEAIKQNGCALKYVDESLRKDKEIIL 1013
                  778888888888888888888888777655 PP

>> Kinase-PolyVal  Serine/Threonine/Tyrosine Kinase found in polyvalent proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.97   1.5e+03     101     138 ..     365     402 ..     333     405 .. 0.72
   2 ?    4.6   0.1      0.02        29      95     140 ..     409     454 ..     406     465 .. 0.89
   3 ?    2.6   0.1      0.08   1.2e+02      95     139 ..     497     541 ..     489     550 .. 0.91
   4 ?    2.4   0.1     0.088   1.3e+02     102     139 ..     554     591 ..     539     601 .. 0.84
   5 ?    2.7   0.1     0.071   1.1e+02      95     139 ..     622     666 ..     605     676 .. 0.88
   6 ?   -2.2   0.0       2.4   3.5e+03     105     139 ..     707     741 ..     700     743 .. 0.82
   7 ?   -2.5   0.0       2.9   4.3e+03     103     139 ..     782     818 ..     758     830 .. 0.67
   8 ?   -1.7   0.0       1.6   2.5e+03     102     139 ..     806     843 ..     787     854 .. 0.79
   9 ?    4.1   0.1     0.028        41     102     139 ..     856     893 ..     847     903 .. 0.86
  10 ?    2.5   0.1     0.083   1.2e+02     101     139 ..     905     943 ..     885     952 .. 0.86
  11 ?    4.6   0.0     0.018        28     104     139 ..     933     968 ..     921     990 .. 0.86
  12 ?   -1.6   0.0       1.5   2.2e+03     104     139 ..     983    1018 ..     971    1028 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.97
  Kinase-PolyVal 101 eevdleevkeflekngfentrnndyinkelgliledlh 138
                      + d e v e +++ gf   + ++   k+ +++le+++
      EFC35894.1 365 LRKDREIVLEAIKQYGFALGYADESLRKDREIVLEAIK 402
                     44556666777777888888888888888888888775 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.02
  Kinase-PolyVal  95 pfikadeevdleevkeflekngfentrnndyinkelgliledlhde 140
                     ++++++ + d e v e +++ngf  ++ ++   k+ +++le+++++
      EFC35894.1 409 KYVDESLRKDREFVLEAVKQNGFALKYVDESLRKDREIVLEAVKQN 454
                     588899999999999***************************9984 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.08
  Kinase-PolyVal  95 pfikadeevdleevkeflekngfentrnndyinkelgliledlhd 139
                     ++++++ + + e v e +++ngf  ++ ++   k+ +++le++++
      EFC35894.1 497 EYVDESLRKNREFVLEAVKQNGFAFKYVDESLRKDREIVLEAVKQ 541
                     58888888899999999*************************987 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.088
  Kinase-PolyVal 102 evdleevkeflekngfentrnndyinkelgliledlhd 139
                     + d++ v e +++ngf  ++ ++   k+ +++le++++
      EFC35894.1 554 RKDKQFVLEAVKQNGFALKYVDESLRKDKEIVLEAVKQ 591
                     566777888999**********************9987 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.071
  Kinase-PolyVal  95 pfikadeevdleevkeflekngfentrnndyinkelgliledlhd 139
                     ++++++ + d e v e ++++gf  ++ ++   k+ +++le++++
      EFC35894.1 622 KYVDESLRKDREFVLEAVKQTGFAFKYADESLRKDKEIVLEAVKQ 666
                     58888888999999999999********************99987 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 2.4
  Kinase-PolyVal 105 leevkeflekngfentrnndyinkelgliledlhd 139
                      e v e +++ng   ++ ++   k+ +++le++++
      EFC35894.1 707 REFVLEAVKQNGCALEDADESLRKDKEIVLEAVKQ 741
                     55566778999999999999999999999999986 PP

  == domain 7  score: -2.5 bits;  conditional E-value: 2.9
  Kinase-PolyVal 103 vdleevkeflekngfentrnndyinkelgliledlhd 139
                      d e v e +++ng   ++ ++   k+ + +le++++
      EFC35894.1 782 KDREFVLEAVKQNGCALEYADNSLRKDKEFVLEAVKQ 818
                     3455566777888999999999999999999998876 PP

  == domain 8  score: -1.7 bits;  conditional E-value: 1.6
  Kinase-PolyVal 102 evdleevkeflekngfentrnndyinkelgliledlhd 139
                     + d+e v e +++ng   ++ ++   k+ +++le++++
      EFC35894.1 806 RKDKEFVLEAVKQNGRALEDADNSLRKDREIVLEAIKQ 843
                     55666777888889999999999999999999998876 PP

  == domain 9  score: 4.1 bits;  conditional E-value: 0.028
  Kinase-PolyVal 102 evdleevkeflekngfentrnndyinkelgliledlhd 139
                     + d+e v e +++ngf  ++ ++   k+ +++le++++
      EFC35894.1 856 RKDKEFVLEAVKQNGFALEYADELLRKDREIVLEAVKQ 893
                     56677788999************************987 PP

  == domain 10  score: 2.5 bits;  conditional E-value: 0.083
  Kinase-PolyVal 101 eevdleevkeflekngfentrnndyinkelgliledlhd 139
                      + d e v e +++ gf  ++ ++   k+ +++le++++
      EFC35894.1 905 LRKDREIVLEAIKQYGFALEYADELLRKDREIVLEAVKQ 943
                     5567778889999***********************987 PP

  == domain 11  score: 4.6 bits;  conditional E-value: 0.018
  Kinase-PolyVal 104 dleevkeflekngfentrnndyinkelgliledlhd 139
                     d e v e +++ngf  ++ ++   k+ ++ile++++
      EFC35894.1 933 DREIVLEAVKQNGFALEDADESLRKDKEIILEAVKQ 968
                     5667788999***********************987 PP

  == domain 12  score: -1.6 bits;  conditional E-value: 1.5
  Kinase-PolyVal  104 dleevkeflekngfentrnndyinkelgliledlhd 139 
                      d e v e +++ng   ++ ++   k+ ++ile++++
      EFC35894.1  983 DREIVLEAIKQNGCALKYVDESLRKDKEIILEAVKQ 1018
                      566677888999999999999999999999999875 PP

>> P_C10  Protein C10
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0      0.14   2.1e+02      50      63 ..     370     383 ..     369     388 .. 0.85
   2 ?    1.8   0.0      0.17   2.5e+02      50      62 ..     395     407 ..     394     415 .. 0.88
   3 ?    2.6   0.0     0.095   1.4e+02      50      63 ..     910     923 ..     909     957 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.14
       P_C10  50 qiqmevikkyGFae 63 
                 +i  e+ik+yGFa 
  EFC35894.1 370 EIVLEAIKQYGFAL 383
                 6889********85 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.17
       P_C10  50 qiqmevikkyGFa 62 
                 +i  e+ik+yGFa
  EFC35894.1 395 EIVLEAIKQYGFA 407
                 6889********8 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.095
       P_C10  50 qiqmevikkyGFae 63 
                 +i  e+ik+yGFa 
  EFC35894.1 910 EIVLEAIKQYGFAL 923
                 68899*******94 PP

>> DUF5551  Family of unknown function (DUF5551)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.37   5.6e+02      48      78 ..     320     350 ..     299     379 .. 0.73
   2 ?   -2.2   0.0       1.9   2.8e+03      54      79 ..     451     476 ..     418     521 .. 0.67
   3 ?    2.6   0.0     0.065        97       6      79 ..     768     841 ..     763     857 .. 0.85
   4 ?   -1.6   0.0       1.3   1.9e+03      47      78 ..     884     915 ..     853     924 .. 0.76
   5 ?    1.1   0.0      0.19   2.8e+02      21      78 ..     958    1015 ..     939    1061 .. 0.64

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.37
     DUF5551  48 emyipdmnrpgkaerraekglrpprelaget 78 
                 e+ +  +++ g a + a+k lr  re+  e+
  EFC35894.1 320 EVVLEAVKQDGLAFKYADKSLRKDREIVLEA 350
                 5556667777888888888888888887665 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.9
     DUF5551  54 mnrpgkaerraekglrpprelagetr 79 
                 +++ g a   a++ lr  re+  e+ 
  EFC35894.1 451 VKQNGCALEDADESLRKDREIVLEAV 476
                 44555555555555555555555443 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.065
     DUF5551   6 rriysmesmapeisedigcllaymkesvcvllisqsffscvaemyipdmnrpgkaerraekglrpprelagetr 79 
                 + i ++e     + +d   +l  +k++ c l  +++ +    e+ +  +++ g+a   a++ lr  re+  e+ 
  EFC35894.1 768 QNISALEDADELLRKDREFVLEAVKQNGCALEYADNSLRKDKEFVLEAVKQNGRALEDADNSLRKDREIVLEAI 841
                 5566677766667788889999999999***9999999999***************************987765 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 1.3
     DUF5551  47 aemyipdmnrpgkaerraekglrpprelaget 78 
                  e+ +  +++ g+a   a++ lr  re+  e+
  EFC35894.1 884 REIVLEAVKQNGRALEYADNSLRKDREIVLEA 915
                 56777788899999999999999999998775 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.19
     DUF5551   21 digcllaymkesvcvllisqsffscvaemyipdmnrpgkaerraekglrpprelaget 78  
                  d   +l  +k++ c l  ++ ++    e+ +  +++ g a +  ++ lr  +e+  e+
  EFC35894.1  958 DKEIILEAVKQTGCALEYADELLRKDREIVLEAIKQNGCALKYVDESLRKDKEIILEA 1015
                  5555566666666666666666666666666666666666666666666666655443 PP

>> DUF2971  Protein of unknown function (DUF2971)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       2.8   4.2e+03       9      52 ..     328     371 ..     325     382 .. 0.71
   2 ?    3.1   0.1      0.15   2.2e+02      10      61 ..     869     920 ..     849     960 .. 0.58
   3 ?    3.2   0.0      0.13     2e+02       9      76 ..     968    1036 ..     965    1060 .. 0.57
   4 ?    1.0   0.0      0.67     1e+03       8      56 ..    1017    1065 ..    1015    1073 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 2.8
     DUF2971   9 hkGvclgfdkeklkedteeglaeekkssesviYeeeeenktile 52 
                 + G ++ + +++l++d e  l+ +k+  + + Y++e  +k+ + 
  EFC35894.1 328 QDGLAFKYADKSLRKDREIVLEAIKQNGRALEYADESLRKDREI 371
                 56788888888888888888888887777788888776665554 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.15
     DUF2971  10 kGvclgfdkeklkedteeglaeekkssesviYeeeeenktileevekeieee 61 
                 +G++l++ +e l++d e  l+  k+  + + Y+++  +k+ +   e  +++ 
  EFC35894.1 869 NGFALEYADELLRKDREIVLEAVKQNGRALEYADNSLRKDREIVLEAIKQYG 920
                 5666666666666666666665555555566655555544444443333333 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.13
     DUF2971    9 hkGvclgfdkeklkedteeglaeekkssesviYeeeeenktileevekeieee...eeeeeekklnKhkdw 76  
                  ++G++l++ +e l++d e  l+ +k+    + Y +e  +k+++ + e  +++    ++++e+ +  K+k++
  EFC35894.1  968 QTGCALEYADELLRKDREIVLEAIKQNGCALKYVDESLRKDKEIILEAVKQTGcalKYADESLR--KDKEF 1036
                  5677777777777777777777776666666666666555555555555444321111111111..44443 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.67
     DUF2971    8 nhkGvclgfdkeklkedteeglaeekkssesviYeeeeenktileevek 56  
                  +++G++l + +e+l++d e  l+  k+  + + Y++e  +k+ +  +++
  EFC35894.1 1017 KQTGCALKYADESLRKDKEFVLEAVKQNRRALEYADESLRKDRELYWKQ 1065
                  579************9999999999888888999999887776665555 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       6.9     1e+04       5      19 ..     125     139 ..     124     161 .. 0.73
   2 ?    4.5   0.2     0.033        49      18      99 ..     314     398 ..     309     405 .. 0.82
   3 ?    2.3   3.2      0.15   2.3e+02      25      57 ..     507     539 ..     407     595 .. 0.55
   4 ?    3.8   0.8     0.054        81      30      99 ..     562     636 ..     551     669 .. 0.79
   5 ?    1.3   4.2      0.31   4.6e+02      49      87 ..     681     719 ..     624     790 .. 0.57
   6 ?    7.7   0.6    0.0032       4.8      25      97 ..     784     861 ..     771     868 .. 0.83
   7 ?    4.2   0.3      0.04        60      28     100 ..     862     939 ..     847     944 .. 0.79
   8 ?    2.6   0.4      0.12   1.8e+02      26      83 ..     960    1017 ..     922    1047 .. 0.55

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 6.9
      AAA_18   5 GtpGvGKttlakeLs 19 
                 G+  +GK  l+++L+
  EFC35894.1 125 GKNKSGKLFLCEALQ 139
                 667789999999986 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.033
      AAA_18  18 Lskrlgfgvnlrdvakenglllevdpealdeskrldedkldklldaleenssaleegknlvidghlaeleseaakdikk.....vvL 99 
                 Lsk +   +++ + +k++gl + + ++ l++ ++++ +  +++ +ale ++++l++   +v++ + +  +   + d        +vL
  EFC35894.1 314 LSKDN--REVVLEAVKQDGLAFKYADKSLRKDREIVLEAIKQNGRALEYADESLRKDREIVLEAIKQYGFALGYADESLrkdreIVL 398
                 66666..77888899999*********9**********************999**********998888776666644444455555 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.15
      AAA_18  25 gvnlrdvakenglllevdpealdeskrldedkl 57 
                  + + + +k+ng  + + +e l++ ++++ + +
  EFC35894.1 507 REFVLEAVKQNGFAFKYVDESLRKDREIVLEAV 539
                 333333344444444444444444444444444 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.054
      AAA_18  30 dvakenglllevdpealdeskrldedkldklldaleenssaleegknlvidghlaeleseaakdikk.....vvL 99 
                 + +k+ng  l + +e l++ k+++ + ++++ +ale ++++l++    v++ + ++ +  +++d        +vL
  EFC35894.1 562 EAVKQNGFALKYVDESLRKDKEIVLEAVKQNRRALEDADESLRKDREFVLEAIKQNGFALKYVDESLrkdreFVL 636
                 566777778888888899999999999999999999999999999999999999998887777755455555555 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.31
      AAA_18  49 skrldedkldklldaleenssaleegknlvidghlaele 87 
                  ++++ +  +++ +ale ++++l++    v++ + ++ +
  EFC35894.1 681 DREIVLEAIKQNRRALEDADESLRKDREFVLEAVKQNGC 719
                 333333333333333333333333333333333333333 PP

  == domain 6  score: 7.7 bits;  conditional E-value: 0.0032
      AAA_18  25 gvnlrdvakenglllevdpealdeskrldedkldklldaleenssaleegknlvidghlaeleseaakdikk.....v 97 
                  + + + +k+ng+ le+ ++ l++ k+++ + ++++ +ale ++++l++   +v++ + ++ +  a+ d+       +
  EFC35894.1 784 REFVLEAVKQNGCALEYADNSLRKDKEFVLEAVKQNGRALEDADNSLRKDREIVLEAIKQNGRALAYADNSLrkdkeF 861
                 6677888999**********************************9************999988888777664555555 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.04
      AAA_18  28 lrdvakenglllevdpealdeskrldedkldklldaleenssaleegknlvidghlaeleseaakdikk.....vvLt 100
                 + + +k+ng  le+ +e l++ ++++ + ++++ +ale ++++l++   +v++ + +  +  ++ d        +vL+
  EFC35894.1 862 VLEAVKQNGFALEYADELLRKDREIVLEAVKQNGRALEYADNSLRKDREIVLEAIKQYGFALEYADELLrkdreIVLE 939
                 55678899999999999999*******************999999*******99988887655555333345555555 PP

  == domain 8  score: 2.6 bits;  conditional E-value: 0.12
      AAA_18   26 vnlrdvakenglllevdpealdeskrldedkldklldaleenssaleegknlvidghl 83  
                  +++ + +k+ g+ le+ +e l++ ++++ +  +++  al+  +++l++ k ++++ + 
  EFC35894.1  960 EIILEAVKQTGCALEYADELLRKDREIVLEAIKQNGCALKYVDESLRKDKEIILEAVK 1017
                  3333444444555555555555555555555555555555555555555555555554 PP

>> CLTH  CTLH/CRA C-terminal to LisH motif domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.21   3.1e+02      55      92 ..     328     388 ..     257     413 .. 0.66
   2 ?   -0.1   3.8       0.5   7.5e+02      60      93 ..     996    1029 ..     620    1071 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.21
        CLTH  55 t.......................kdieealeyarenlefendehlkelekamsLLafsdp 92 
                 +                       k+  +aleya e l+++ +  l+ +++   +L + d 
  EFC35894.1 328 QdglafkyadkslrkdreivleaiKQNGRALEYADESLRKDREIVLEAIKQYGFALGYADE 388
                 0444444444445544555555555567899999999998888899999988888877774 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.5
        CLTH   60 ealeyarenlefendehlkelekamsLLafsdpe 93  
                   al+y+ e l+++++  l+ ++++  +L + d +
  EFC35894.1  996 CALKYVDESLRKDKEIILEAVKQTGCALKYADES 1029
                  3555555555555555555555555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1080 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       832  (0.0464053); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                        29  (0.00161749); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 1.45u 0.34s 00:00:01.79 Elapsed: 00:00:00.53
# Mc/sec: 6117.19
//
Query:       EFC35895.1  [L=214]
Description: hypothetical protein NAEGRDRAFT_54684, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.1e-28   97.9   0.2    8.2e-28   97.7   0.2    1.0  1  Trypsin    Trypsin
    0.00079   20.3   0.0     0.0012   19.8   0.0    1.3  1  Trypsin_2  Trypsin-like peptidase domain


Domain annotation for each model (and alignments):
>> Trypsin  Trypsin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.7   0.2   9.1e-32   8.2e-28       3     169 ..      36     212 ..      34     214 .] 0.86

  Alignments for each domain:
  == domain 1  score: 97.7 bits;  conditional E-value: 9.1e-32
                 SSEETTTTSSTTEEEEEETTC....EEEEEEEEEETTEEEEEGGGTTTGGGEEEEESESBTTSCTTTEEEEEEEEEEEETTEBTTTTTTTEEEEEESSS CS
     Trypsin   3 ggeeaqkgsfpwqvslsvksg....khlCgGslisenwvlTAaHCvsnasdvkvvlgehnlkksegkeqklkvekvivhpnynpstldnDiallklkep 97 
                 +g++a +++fp++vs++ + +    +hlC+Gs++s+ +vlTAaHC+++++ + vv g+++ + s++  +++kv++ i hp y++ t  nDia+ +l++ 
  EFC35895.1  36 NGQTAGEHEFPFIVSIQKQLSsgafEHLCTGSILSSTFVLTAAHCLDSSTTLVVVYGTYDNTCSDN-CKYIKVKNQIAHPSYQKGTERNDIAVFELESA 133
                 799999**********9877778*************************9999999***88888888.49****************************** PP

                 STSBS.SBHCCBBCS.....TTHTTSTTTEEEEEESSBSSTSS.BSSBEEEEEEEEEEHHHHHHHTTTTSTTTEEEEES CS
     Trypsin  98 vklgd.tvrpiclpa.....assslpvgttclvsGwgrtkekg.ksdtlqevevpvvsretcksaykgkvtenmlcaga 169
                 + + d tv+++++ a      ++++   + +l+sGwg  +++  ++++lq++ vp+v+ + c++   g v+ +++caga
  EFC35895.1 134 LPIDDsTVSTVSIDAnsiaiHDEESDSSRLVLISGWGALNSNLdYPKKLQKASVPIVKMSYCNNLNLGGVNIEQICAGA 212
                 665432566666666666665555578889********666666********************855559********8 PP

>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.0   1.3e-07    0.0012       1      64 [.      64     135 ..      64     193 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 1.3e-07
   Trypsin_2   1 GsGflvgsdglilTnaHvvdsadgaav.......kaikkkveeagadgrevpakvvaadpelDlAllkv...ss 64 
                 ++G +++s+  +lT+aH++ds+++ +v       ++  ++ ++  ++  ++p    +++ + D+A++++    +
  EFC35895.1  64 CTGSILSSTF-VLTAAHCLDSSTTLVVvygtydnTCSDNCKYIKVKNQIAHPSYQKGTE-RNDIAVFELesaLP 135
                 699999***9.****************88777766666666666666666666666666.88*******75522 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       327  (0.0182386); expected 358.6 (0.02)
Passed bias filter:                      243  (0.0135535); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1332.30
//
Query:       EFC35896.1  [L=512]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
        1.1    7.9   4.0        1.4    7.5   4.0    1.1  1  Ndc1_Nup    Nucleoporin protein Ndc1-Nup
        2.8    7.3   8.1        6.6    6.1   7.8    1.7  2  Paramyxo_C  Paramyxovirus non-structural protein C


Domain annotation for each model (and alignments):
>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   4.0   0.00016       1.4     394     461 ..     294     360 ..     268     425 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00016
    Ndc1_Nup 394 gnsltaeaspkssssskegvekalsslakspgqspsptarlsprarkllekaksrllskeqkealses 461
                 g+s+  +as++sss+s++g +++ +  ak++++sp+   r+s +ar++ +++++++++++++ + +++
  EFC35896.1 294 GKSRGGKASSSSSSASSKGARRSAATKAKATNKSPTDLGRVSVTARRTSKTKTTQQQQQQES-KETKN 360
                 22333445556666777788888888888888888888888877887777777766662222.22222 PP

>> Paramyxo_C  Paramyxovirus non-structural protein C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   7.8   0.00073       6.6      20     113 ..     277     369 ..     264     382 .. 0.82
   2 ?   -3.2   0.0      0.49   4.4e+03     114     134 ..     480     500 ..     474     509 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.00073
  Paramyxo_C  20 srsrmlsdsstqsyqvnqltsegteagstipstpskgqalpteskvrareksrhrrpkiidqvrrveslgeqasqrqkhmletlinkiytgplg 113
                 s sr  s s  +s   n   s g +a s+  s+ skg    + +k +a +ks     ++    rr         q+q+   et  n+  +g  g
  EFC35896.1 277 SGSRSSSRSGRNS-GRNSGKSRGGKASSSSSSASSKGARRSAATKAKATNKSPTDLGRVSVTARRTSKTKTTQQQQQQESKETKNNRTKSGGEG 369
                 4555555554444.5688899********************************************99998888999999999999998888665 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.49
  Paramyxo_C 114 eelvqtlylriwameetpesl 134
                 + lv t y++++ +e++   +
  EFC35896.1 480 DRLVATQYVKLYGIENASRRI 500
                 579999999999999887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (512 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1836  (0.102404); expected 358.6 (0.02)
Passed bias filter:                      708  (0.0394891); expected 358.6 (0.02)
Passed Vit filter:                       108  (0.00602376); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.88u 0.38s 00:00:01.26 Elapsed: 00:00:00.53
# Mc/sec: 2932.18
//
Query:       EFC35897.1  [L=139]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.18   11.7   1.5       0.32   10.9   1.5    1.4  1  DUF3377   Domain of unknown function (DUF3377)
        3.2    7.3   5.5        6.7    6.3   5.5    1.5  1  NapE      Periplasmic nitrate reductase protein NapE


Domain annotation for each model (and alignments):
>> DUF3377  Domain of unknown function (DUF3377)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   1.5   3.6e-05      0.32      22      56 ..      82     119 ..      73     125 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 3.6e-05
     DUF3377  22 eesgtvnaiaVvvPlvLllci....Lvliyailqfrrkg 56 
                 e +++v ++aVvvP+v +++i     vli +i+ + +k 
  EFC35897.1  82 E-NTGVIVAAVVVPIVSVAVIgsgvAVLITTIVIMMKKK 119
                 3.4568999******988875333368888888855554 PP

>> NapE  Periplasmic nitrate reductase protein NapE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   5.5   0.00075       6.7      20      37 ..      86     103 ..      83     114 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.00075
        NapE  20 lfltvvlfPiLsValVgg 37 
                 +++++v++Pi+sVa++g+
  EFC35897.1  86 VIVAAVVVPIVSVAVIGS 103
                 57899***********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (139 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       825  (0.0460148); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.31s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 864.89
//
Query:       EFC35898.1  [L=316]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-10   39.8   0.1    5.8e-10   39.0   0.1    1.3  1  Ras       Ras family
    0.00095   19.4   0.0     0.0021   18.3   0.0    1.7  1  Roc       Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.092   12.3   0.1       0.23   11.0   0.1    1.6  2  GTP_EFTU  Elongation factor Tu GTP binding domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.1   9.7e-14   5.8e-10       1     157 [.     129     295 ..     129     298 .. 0.81

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 9.7e-14
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTS.GGGHHHHHHHHTTESEEEEEEETTBH.HHHHTHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGq.eefkslrelyyrdaegillvyditsr.esfenvkkwveei 97 
                 Kl + G ++ G  s+++r+ +d F ++y+  i  d + k+i +++++v+leiw T     ++  + e+ +++a+g +++  i+   + +   +++++ i
  EFC35898.1 129 KLCITGPGGSGIHSFIHRYLNDVFYDQYDYSI-DDIFYKTILFNERKVELEIWETGFRsTDYYLFLESKLKGARGYIVLLPIHADvDKYGVFERIIKSI 226
                 88999***************************.9*********************865268999999**************986527889999999999 PP

                 HHHSTTTSEEEEEE.ETTTGGG......G-SS-HHHHH..HHHHHHTSEEEEEBTTTTCTHHHHHHHHH CS
         Ras  98 krvaeenvpivLvG.nKvDlee......kravsteege..elakelglkfletSAktnenveeafeell 157
                   + +++ + +L+G +++D  e        +v+++     ++ + l+++ +etS k+n n+++++e++l
  EFC35898.1 227 VYMHDDESVPLLIGiTQIDKLEtnsslnLDQVKQKVTDimNVYSCLDFEIVETSSKSNINIHTVIEKAL 295
                 999885555555653788965556666634444333330034456667889*************99875 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   3.5e-07    0.0021       1      88 [.     129     208 ..     129     246 .. 0.69

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 3.5e-07
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SG.GCTTTT-HHHHCTSCEEEEEEE CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGq.erfrslhplylreaalailvyd 88 
                 K+++ G +g+G  s+++r+++d f ++++  i   f++ ++       n+   +kv+l+iW t+   ++++   ++ l++a  +i+++ 
  EFC35898.1 129 KLCITGPGGSGIHSFIHRYLNDVFYDQYDYSIDDIFYK-TIL-----FNE---RKVELEIWETGFRsTDYYLFLESKLKGARGYIVLLP 208
                 899**************************999877765.442.....233...4699******98525677777888888888887764 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.35   2.1e+03     131     157 ..      90     115 ..      66     151 .. 0.56
   2 ?   11.0   0.1   3.8e-05      0.23     109     187 ..     221     293 ..     186     297 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.35
                 SCGSTHHHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU 131 KmDrlkaelkeiveevkqklsrkeekl 157
                 K D++ +e+ e ++  k+++ +  +++
  EFC35898.1  90 KKDQTLQEFVERKRSFKRSF-AILNEM 115
                 44555566666666666555.223333 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 3.8e-05
                 HHHHHHHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHH CS
    GTP_EFTU 109 pqteevlrlalkegvpiivfiNKmDrlkaelkeiveevkqklsrkeeklekygekgekevpvvfgSalkgegvktllea 187
                    + ++++  +e vp+ + i+ +D+l+++ +   ++vkqk+   ++ +++y      ++++v +S++++ ++ t++e 
  EFC35898.1 221 RIIKSIVYMHDDESVPLLIGITQIDKLETNSSLNLDQVKQKV---TDIMNVYSCL---DFEIVETSSKSNINIHTVIEK 293
                 4567778888999**************************999...4444444333...699************999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       811  (0.045234); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.24s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 2094.82
//
Query:       EFC35899.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.019   14.5   0.0      0.024   14.1   0.0    1.1  1  Tab2_like  RNA-binding protein Tab2/Atab2


Domain annotation for each model (and alignments):
>> Tab2_like  RNA-binding protein Tab2/Atab2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   1.3e-06     0.024      97     157 ..      97     155 ..      89     161 .] 0.80

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.3e-06
   Tab2_like  97 leereeevYpqeegyteqaaakeplaldkpppvpLPdalrgekwafvsLeaseleeakewe 157
                 l   ++++Y +++g ++++  ++  +  +++ ++L d++  ++w fv+L+ s l+e ++ +
  EFC35899.1  97 LPASAKDIYLRNHGNSSNP--SSASSNPNRNTNKLDDEFFADNWYFVELHQSILQESTHSN 155
                 6667889999999997777..555566678889*********************9986655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 1031.62
//
Query:       EFC35900.1  [L=306]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      2e-27   96.2   3.1    7.5e-27   94.3   3.1    1.8  1  Pkinase         Protein kinase domain
    1.8e-17   63.5   0.2    2.3e-17   63.1   0.2    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    4.9e-05   22.3   0.1      7e-05   21.8   0.1    1.3  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.021   14.9   0.5        4.8    7.3   0.0    2.9  2  DUF3791         Protein of unknown function (DUF3791)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.3   3.1   1.7e-30   7.5e-27      28     246 ..       4     257 ..       1     293 [. 0.73

  Alignments for each domain:
  == domain 1  score: 94.3 bits;  conditional E-value: 1.7e-30
                 EEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE....SSEEE.EEEE--TTEBHHHHHHHHSS--HH....................... CS
     Pkinase  28 AvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee....kdely.lvleyveggeladllerkgslsee....................... 98 
                 A+K+ +++  +++   ++++  k  k+++hpn+vr++++       + +l+ +v+e+++ + l++++ ++++++++                       
  EFC35900.1   4 ALKTYRESTVSNDLP-RLIEAFKRAKEFNHPNVVRYLDYGVLeqsfE-NLHfVVMELAPLD-LEKYILNHSVVNSDsgnerfrigevsqnknreyslsl 99 
                 778777777777665.78888899999*********87644323643.3433788888866.6666654444444445555555555666666666666 PP

                 .HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE..EEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH....TTSCBSHHHHHHHHHHHHH CS
     Pkinase  99 .eakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelesssk.ltsfvgtseYlAPEvl....keneyskkvDvWslGvily 188
                  e+  +++ il+g +ylH+++iiHrDlKp+NiLi   +ge   Ki+D + +k  e +   +t + gt+eY APE+     ++n+  ++vD++slG+i +
  EFC35900.1 100 kEVTLLFRDILKGYDYLHQNKIIHRDLKPQNILIYrVQGEivPKISDHDECKISELDLVrTTMIQGTREYAAPELFekhlSNNNLYETVDIYSLGCIYL 198
                 6**********************************66777889*********999876669999***********9888788999***********988 PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT..SHH...HHHTTS-HHHHHHHHHHT- CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilg..etkeklpeaseiseeakdllkkllk 246
                  +l ++ +   + ++   +++++q ek+ + ++   + +  +++++i + +++ll   +k
  EFC35900.1 199 FVLIKTCLEV-DGKTFFDWMIVNQEEKVHNFIKerIEMLYKNTNEKIRNCIIRLLYCTIK 257
                 8877665544.4444445666666566555555432223333444445555555554444 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.1   0.2   5.2e-21   2.3e-17      31     200 ..       3     203 ..       1     268 [. 0.81

  Alignments for each domain:
  == domain 1  score: 63.1 bits;  conditional E-value: 5.2e-21
                  EEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSS....EEEEEE--TTEBHHHHHHHT......................CTTTSBH CS
  Pkinase_Tyr  31 VavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeep....llivteyvkgGdLlkfLrkk......................ekekltl 102
                   a+Kt +e++ +++  +l+e  k  k+++hpn+v++l   + e++    +++v+e+++  dL+k++ ++                      ++ +l+l
   EFC35900.1   3 AALKTYRESTVSNDLPRLIEAFKRAKEFNHPNVVRYLDYGVLEQSfenlHFVVMELAPL-DLEKYILNHsvvnsdsgnerfrigevsqnknREYSLSL 99 
                  589********************************976555333333569999**9998.9*****9999*******************998999*** PP

                  HHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE...TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE....EEHHHHHHHHHH CS
  Pkinase_Tyr 103 kdllsfalqvAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk....ftsksDvWsfGv 193
                  k+++ +  ++ kG +yL+++k++Hrdl  +N+L+ +   + v kisD   ++    + + v+++  +   ++ apE ++++     + +  D++s G 
   EFC35900.1 100 KEVTLLFRDILKGYDYLHQNKIIHRDLKPQNILIYRvqgEIVPKISDHDECKIS--ELDLVRTTMIQGTREYAAPELFEKHLsnnnLYETVDIYSLGC 195
                  *********************************998664557799999988755..77778889999999******99887766668899******96 PP

                  H.HHHHHT CS
  Pkinase_Tyr 194 l.lwEift 200
                  + l+ +++
   EFC35900.1 196 IyLFVLIK 203
                  51444444 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.1   1.6e-08     7e-05     306     360 ..     100     159 ..      70     184 .. 0.83

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 1.6e-08
  Pkinase_fungal 306 kellealrDaIkghrsLflkagiLHrDiSenNilitdskke......gerkglLiDLDlak 360
                     ke+   +rD +kg+  L+ + +i+HrD   +Nili+  + e      ++++  +++LDl  
      EFC35900.1 100 KEVTLLFRDILKGYDYLH-QNKIIHRDLKPQNILIYRVQGEivpkisDHDECKISELDLVR 159
                     5666679***********.*****************6565566666666677777777754 PP

>> DUF3791  Protein of unknown function (DUF3791)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.0    0.0011       4.8       6      59 ..      20      69 ..      17      70 .. 0.88
   2 ?    4.6   0.2    0.0074        33      12      37 ..      93     119 ..      89     120 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0011
     DUF3791  6 cIeeyarklglsgkevykllkksgvldylidcYevlHtqSkeyivedideylkn 59
                +Ie+++r++  +  +v+++l+ +gv   l++++e lH    e +  d+++y+ n
  EFC35900.1 20 LIEAFKRAKEFNHPNVVRYLD-YGV---LEQSFENLHFVVMELAPLDLEKYILN 69
                7*******************6.888...99999999999999888888888876 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0074
     DUF3791  12 rklglsgkevykllk.ksgvldylidc 37 
                 r+++ls kev  l++   +++dyl+++
  EFC35900.1  93 REYSLSLKEVTLLFRdILKGYDYLHQN 119
                 678999999999999778999999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (306 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       752  (0.0419432); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1743.11
//
Query:       EFC35901.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      5e-10   39.6  10.6    8.6e-10   38.9  10.6    1.3  1  FA_desaturase  Fatty acid desaturase


Domain annotation for each model (and alignments):
>> FA_desaturase  Fatty acid desaturase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.9  10.6   4.8e-14   8.6e-10       6     235 ..      56     288 ..      49     298 .. 0.63

  Alignments for each domain:
  == domain 1  score: 38.9 bits;  conditional E-value: 4.8e-14
  FA_desaturase   6 llla.lllglfllgitg.slaHeaaHgalfkkrklnrwlndllgallglplgi..sysawrisH.lrHHaytngp.deDpdlaplal......... 86 
                    l+l+ l++     g ++    H+++H+     ++ln+++ dll   lg+ +g   +++  +i H  +HH + +g+  +  +   +a+         
     EFC35901.1  56 LPLVyLIC-----GGRWtLCYHNLLHQ----EKSLNPIV-DLL---LGVGFGHllTFKPGKIGHdSHHHFN-YGQdSRKYSM-DIAQdyltpsdil 136
                    33222333.....33344788999996....55599**9.666...55555555589999****6655544.4430222222.2222466677788 PP

  FA_desaturase  87 ........srfeglfryllrlllgllvlgwllalvlglwlrrlarrrapsksrrrkwrllawlllllawlglwlalllllglalllwlvplllllf 174
                            +  +++ +  ++ + ++++ +    l+ + ++ ++ + ++++k     w +  + +++l  ++l++++ll +++a l+ lv+++l+++
     EFC35901.1 137 yrhkqimqRDADYWCKSSPNRWVLFMRSS----LFDFNYISFYLKKKRDMK-----WKYAPMTFARL--VLLLAPFLLMNPIAYLIHLVMCRLVMT 221
                    77775554222222222333333333333....222236666666666655.....88888888888..************988855555555555 PP

  FA_desaturase 175 llalvlnyveHyg.....gdwgerqvetsasir.saswllnlltgnlnyHieHHlfPgvpwyrLpel 235
                    ++ +v++ + H         +   +++++ +i+     l ++ +++ n H +HH+fP+   + L ++
     EFC35901.1 222 VIFMVFTTLAHEEgwfdsLVDNFYPFQQTVDINlVLEILIGYHIHHVNEHDNHHIFPKRDVSMLEQI 288
                    555555777776668888888888888888888889999999999999999******9988877766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       842  (0.046963); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2135.83
//
Query:       EFC35902.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-17   62.4   0.1    1.1e-10   41.9   0.1    2.1  2  Ank_2     Ankyrin repeats (3 copies)
      1e-13   50.1   0.1      0.004   17.5   0.0    4.2  4  Ank_3     Ankyrin repeat
    8.4e-13   48.6   0.3     0.0015   19.0   0.0    4.0  3  Ank_4     Ankyrin repeats (many copies)
    1.9e-10   40.7   0.1      0.066   13.7   0.1    4.1  4  Ank       Ankyrin repeat
    8.6e-10   38.7   0.1     0.0078   16.5   0.1    4.1  4  Ank_5     Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.9   0.1   3.2e-14   1.1e-10       2      80 ..       4      99 ..       3     102 .. 0.78
   2 !   18.6   0.0   5.8e-07    0.0021      21      49 ..     113     142 ..     101     151 .. 0.67

  Alignments for each domain:
  == domain 1  score: 41.9 bits;  conditional E-value: 3.2e-14
       Ank_2  2 hlAakngnlelvklLleg...adpn.k.ngktaLhyAakngnleivklLleh.....ad.....ndgr.tpLhyAarsghleivklLlek.gadin 80
                  A+kng+ + v+lLl+g   +d+n +    ++L++A+k gn+ ivklLl+      ++     ++ + + L++A   g  +ivklLl   g+++n
  EFC35902.1  4 NKACKNGDVSQVQLLLSGdevVDINdQySYSSPLYAACKLGNIAIVKLLLATgrrvnINkgvhcYTDYcSNLFAAYMRGFRDIVKLLLTIdGINVN 99
                679****99*******554558899646779*******************956664522455564444488****999*99*******43488777 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 5.8e-07
       Ank_2  21 dpnkngktaLhyAakngnleivklLleh....a 49 
                 d   +  ++L+yA+k g+ e+vk+Ll++    +
  EFC35902.1 113 D---KQDFPLYYACKIGDYEMVKWLLKFedieV 142
                 3...34789999999999999999998545332 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.053   1.9e+02       6      23 ..       3      20 ..       2      28 .. 0.80
   2 !   14.7   0.0   9.5e-06     0.034       3      29 ..      34      61 ..      32      63 .. 0.83
   3 !    9.7   0.0   0.00039       1.4       6      30 ..      75      99 ..      71     100 .. 0.91
   4 !   17.5   0.0   1.1e-06     0.004       5      29 ..     118     142 ..     115     144 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.053
       Ank_3  6 LhlAarsgnleivkfLle 23
                L  A+++g+++ v++Ll 
  EFC35902.1  3 LNKACKNGDVSQVQLLLS 20
                789*******55999997 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 9.5e-06
       Ank_3  3 etpLhlAarsgnleivkfLle.nkgadv 29
                 +pL+ A++ gn++ivk+Ll   + +++
  EFC35902.1 34 SSPLYAACKLGNIAIVKLLLAtGRRVNI 61
                59******************95555555 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00039
       Ank_3  6 LhlAarsgnleivkfLlenkgadvn 30
                L+ A + g  +ivk+Ll + g++vn
  EFC35902.1 75 LFAAYMRGFRDIVKLLLTIDGINVN 99
                6678899999**************9 PP

  == domain 4  score: 17.5 bits;  conditional E-value: 1.1e-06
       Ank_3   5 pLhlAarsgnleivkfLlenkgadv 29 
                 pL++A++ g++e+vk+Ll+   ++v
  EFC35902.1 118 PLYYACKIGDYEMVKWLLKFEDIEV 142
                 9******************555555 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0    0.0007       2.5      39      55 .]       3      19 ..       1      19 [. 0.92
   2 !   13.7   0.2     2e-05     0.071       2      55 .]      34      91 ..      33      91 .. 0.61
   3 !   19.0   0.0   4.2e-07    0.0015      38      55 .]     118     135 ..     104     135 .. 0.93

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0007
       Ank_4 39 lhiAakrgnveilklLl 55
                l +A+k+g+v+ ++lLl
  EFC35902.1  3 LNKACKNGDVSQVQLLL 19
                789*************8 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2e-05
       Ank_4  2 ltaLhyaaisgrlelvrlLlekg..adinaqdnrsGet....alhiAakrgnveilklLl 55
                +++L +a++ g++ +v+lLl++g  ++in+     + t     l  A +rg+ +i+klLl
  EFC35902.1 34 SSPLYAACKLGNIAIVKLLLATGrrVNINKG-VH-CYTdycsNLFAAYMRGFRDIVKLLL 91
                689999**************76423554442.11.1111221355555777777777776 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 4.2e-07
       Ank_4  38 alhiAakrgnveilklLl 55 
                 +l++A+k+g++e++k+Ll
  EFC35902.1 118 PLYYACKIGDYEMVKWLL 135
                 9****************8 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.029     1e+02       9      28 ..       6      28 ..       3      30 .. 0.78
   2 !   13.7   0.1   1.8e-05     0.066       4      28 ..      35      62 ..      34      64 .. 0.86
   3 !    7.2   0.0    0.0021       7.4      10      28 ..      78      99 ..      66     101 .. 0.75
   4 !   11.2   0.0   0.00011       0.4       5      22 ..     118     135 ..     116     145 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.029
                HHHHTTHHHHHHHHTT...TSTT CS
         Ank  9 AatngkkriiklLLhG...Anln 28
                A+ ng+++ ++lLL+G    ++n
  EFC35902.1  6 ACKNGDVSQVQLLLSGdevVDIN 28
                788999999*****885555555 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1.8e-05
                BHHHHHHHHTTHHHHHHHH.TT..TSTT CS
         Ank  4 TPLHlAatngkkriiklLL.hG..Anln 28
                +PL  A+  g+  i+klLL  G   n+n
  EFC35902.1 35 SPLYAACKLGNIAIVKLLLaTGrrVNIN 62
                79*****999999******877668887 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.0021
                H.HHTTHHHHHHHH..TTTSTT CS
         Ank 10 a.tngkkriiklLL..hGAnln 28
                a ++g  +i+klLL  +G n+n
  EFC35902.1 78 AyMRGFRDIVKLLLtiDGINVN 99
                35444456******988*9998 PP

  == domain 4  score: 11.2 bits;  conditional E-value: 0.00011
                 HHHHHHHHTTHHHHHHHH CS
         Ank   5 PLHlAatngkkriiklLL 22 
                 PL +A+ +g+ +++k+LL
  EFC35902.1 118 PLYYACKIGDYEMVKWLL 135
                 9****************9 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0026       9.2      19      43 ..       2      28 ..       1      30 [. 0.89
   2 !   16.5   0.1   2.2e-06    0.0078       1      43 [.      18      62 ..      18      63 .. 0.80
   3 ?    1.9   0.0     0.086   3.1e+02      22      36 ..      76      91 ..      76     104 .. 0.81
   4 !   12.1   0.0   5.2e-05      0.19      18      37 ..     117     136 ..     109     148 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0026
       Ank_5 19 pLhvAakygaadvvrlLl..argadln 43
                 L+ A+k+g  + v+lLl  ++ +d+n
  EFC35902.1  2 SLNKACKNGDVSQVQLLLsgDEVVDIN 28
                599***************998888887 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 2.2e-06
       Ank_5  1 Llehg.padvnrldgggntpLhvAakygaadvvrlLl..argadln 43
                Ll+ +  +d+n++  ++ +pL  A+k g+  +v+lLl   r++++n
  EFC35902.1 18 LLSGDeVVDINDQYSYS-SPLYAACKLGNIAIVKLLLatGRRVNIN 62
                56666556677776666.*******************888888776 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.086
       Ank_5 22 vAak.ygaadvvrlLl 36
                +Aa+ +g  d+v+lLl
  EFC35902.1 76 FAAYmRGFRDIVKLLL 91
                69999999*******9 PP

  == domain 4  score: 12.1 bits;  conditional E-value: 5.2e-05
       Ank_5  18 tpLhvAakygaadvvrlLla 37 
                  pL +A+k g  ++v++Ll+
  EFC35902.1 117 FPLYYACKIGDYEMVKWLLK 136
                 79*****************4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       425  (0.0237046); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.38u 0.25s 00:00:00.63 Elapsed: 00:00:00.41
# Mc/sec: 1116.55
//
Query:       EFC35903.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.7e-19   68.8   4.3     0.0011   18.9   0.0    5.8  6  NHL           NHL repeat
    0.00028   20.5   0.3        2.9    7.4   0.0    4.0  4  SGL           SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.054   13.9   0.2        8.3    6.8   0.0    3.6  4  ComGF         Putative Competence protein ComGF
      0.068   13.1   0.0         40    4.0   0.0    3.8  4  Phytase-like  Esterase-like activity of phytase
       0.29   10.4   5.8        4.5    6.4   0.1    3.5  4  DUF5050       Domain of unknown function (DUF5050)
        4.1    7.0   7.9        3.6    7.2   0.4    3.6  3  Plasmo_rep    Plasmodium repeat family


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   5.2e-05      0.15       6      27 ..       9      29 ..       4      30 .. 0.81
   2 !   17.9   0.0   7.4e-07    0.0022       1      25 [.      47      71 ..      47      73 .. 0.95
   3 !   12.3   0.1   4.6e-05      0.14       1      27 [.     103     129 ..     103     130 .. 0.90
   4 ?    4.3   0.0     0.016        47      13      27 ..     170     184 ..     165     185 .. 0.85
   5 ?   -2.9   0.0       3.1   9.1e+03       1      16 [.     214     228 ..     214     235 .. 0.68
   6 !   18.9   0.0   3.7e-07    0.0011       1      27 [.     270     296 ..     270     297 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.2e-05
                EEEEETTTEEEEEECCCTEEEE CS
         NHL  6 GvavdsnGdiyVaDsenhrvqv 27
                 + v sn+++++aD++n rv++
  EFC35903.1  9 AIFV-SNDEVFIADTGNDRVRK 29
                4445.9*************987 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 7.4e-07
                BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrv 25
                +++P++++v+s++++y++++e+h +
  EFC35903.1 47 LYNPSSIVVSSSNQVYISENERHLI 71
                789********************87 PP

  == domain 3  score: 12.3 bits;  conditional E-value: 4.6e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P G+ v+++++++ +D++nhrv++
  EFC35903.1 103 LNSPCGLFVTDDDEVLFCDRRNHRVRK 129
                 6778899999***************97 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.016
                 TEEEEEECCCTEEEE CS
         NHL  13 GdiyVaDsenhrvqv 27 
                 ++iy+aDs ++r+++
  EFC35903.1 170 DEIYIADSFSNRIRK 184
                 79*****98888876 PP

  == domain 5  score: -2.9 bits;  conditional E-value: 3.1
                 BSSEEEEEEETTTEEE CS
         NHL   1 fnyPhGvavdsnGdiy 16 
                 +n+P+++ v  n++iy
  EFC35903.1 214 LNNPNSLFVH-NDEIY 228
                 6788887775.77776 PP

  == domain 6  score: 18.9 bits;  conditional E-value: 3.7e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P G+ vds +++y aD++nh+v++
  EFC35903.1 270 LSWPKGIFVDSKNQVYFADYYNHCVRK 296
                 678**********************97 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.0    0.0031       9.3     183     216 ..      97     136 ..      14     141 .. 0.69
   2 ?    2.2   0.0     0.039   1.2e+02     146     165 ..     170     189 ..     167     255 .. 0.73
   3 ?   -0.7   0.0       0.3   8.9e+02      10      46 ..     223     259 ..     216     270 .. 0.79
   4 !    7.4   0.0   0.00096       2.9     184     215 ..     271     302 ..     252     307 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0031
         SGL 183 e......gepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                        + p Gl+v+ +++v  +  ++++v+++d +G +
  EFC35903.1  97 LavnanlNSPCGLFVTDDDEVLFCDRRNHRVRKIDRNGII 136
                 2333333458899999999999999999999999998854 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.039
         SGL 146 ktlYlaDsltrkiwaydvda 165
                 + +Y+aDs  ++i ++d d 
  EFC35903.1 170 DEIYIADSFSNRIRKIDRDG 189
                 57899999999999999885 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.3
         SGL  10 eegaLlwvDilgqrihrldpatgketvldtpesvGai 46 
                  +++++++D  +q i ++ p++  ++ + +p++ G+ 
  EFC35903.1 223 HNDEIYFSDLDNQVIRKILPNGIIKNIAGIPGKKGYN 259
                 4789999999999999999988888887777766665 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.00096
         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdpdGk 215
                 + p G++vD++++v+ A + +++v+++ ++G+
  EFC35903.1 271 SWPKGIFVDSKNQVYFADYYNHCVRKIFKNGN 302
                 4588**********************999986 PP

>> ComGF  Putative Competence protein ComGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0       0.1     3e+02      45      70 ..      56      81 ..      16      96 .. 0.79
   2 ?   -0.9   0.0      0.73   2.2e+03      46      70 ..     113     137 ..     103     140 .. 0.79
   3 ?   -1.4   0.0         1     3e+03      47      63 ..     224     240 ..     210     259 .. 0.66
   4 ?    6.8   0.0    0.0028       8.3      46      77 ..     280     311 ..     264     313 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.1
       ComGF 45 kekktityekynnkirkrvnggGyqp 70
                +  ++++++++++++++++++ G+++
  EFC35903.1 56 SSSNQVYISENERHLIYKIDEFGIMT 81
                45677999999999999999999886 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.73
       ComGF  46 ekktityekynnkirkrvnggGyqp 70 
                 +++++ +  + n+ +++++++G+++
  EFC35903.1 113 DDDEVLFCDRRNHRVRKIDRNGIIT 137
                 6677777778888888889999875 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 1
       ComGF  47 kktityekynnkirkrv 63 
                 +++i+++  +n+ ++++
  EFC35903.1 224 NDEIYFSDLDNQVIRKI 240
                 56677777777766655 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0028
       ComGF  46 ekktityekynnkirkrvnggGyqplLtnVkk 77 
                  k+++++  y n+ ++++ ++G++ ++ ++ +
  EFC35903.1 280 SKNQVYFADYYNHCVRKIFKNGNMKIIAGIGD 311
                 5788888888888888888*****99998865 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.013        40      68      98 ..      48      78 ..       9      96 .. 0.78
   2 ?    1.3   0.0     0.091   2.7e+02      72     100 ..     108     136 ..      82     140 .. 0.89
   3 ?    2.1   0.0     0.051   1.5e+02      78     100 ..     169     191 ..     165     195 .. 0.87
   4 ?   -1.6   0.0      0.67     2e+03      72      99 ..     275     302 ..     209     305 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.013
  Phytase-like 68 lDpEgiavapdgtfwvssEggpfilefdadG 98
                  ++p +i+v++ +++++s+  ++ i+++d  G
    EFC35903.1 48 YNPSSIVVSSSNQVYISENERHLIYKIDEFG 78
                  477799*******************999766 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.091
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkl 100
                   g+ v++d+++++++ ++++++++d++G +
    EFC35903.1 108 GLFVTDDDEVLFCDRRNHRVRKIDRNGII 136
                   778899*******************9965 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.051
  Phytase-like  78 dgtfwvssEggpfilefdadGkl 100
                   ++++++++ + ++i+++d+dG +
    EFC35903.1 169 KDEIYIADSFSNRIRKIDRDGII 191
                   7899****************965 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 0.67
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGk 99 
                   gi v++++++++++ +++ ++++ ++G+
    EFC35903.1 275 GIFVDSKNQVYFADYYNHCVRKIFKNGN 302
                   6777788888888888888877777776 PP

>> DUF5050  Domain of unknown function (DUF5050)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.1     0.069   2.1e+02      10      33 ..      52      74 ..       5      91 .. 0.53
   2 ?   -2.6   0.0      0.85   2.5e+03       9      23 ..     107     121 ..     100     134 .. 0.65
   3 ?    6.4   0.1    0.0015       4.5     161     196 ..     200     235 ..     165     243 .. 0.80
   4 ?    3.7   0.2      0.01        31       9      28 ..     274     293 ..     272     304 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.069
                T-EEEETTEEEEE-GGGTTEEEEE CS
     DUF5050 10 GlfcekdgkiYFsnpydenkLYkm 33
                 +++++ +++Y s  ++++ +Yk+
  EFC35903.1 52 SIVVSSSNQVYIS-ENERHLIYKI 74
                2223333333333.2223333333 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.85
                 TT-EEEETTEEEEE- CS
     DUF5050   9 gGlfcekdgkiYFsn 23 
                  Glf+++d+++ F  
  EFC35903.1 107 CGLFVTDDDEVLFCD 121
                 489999999998853 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0015
                 EEEETTTTEEEEEE-S-EEEEEEEETTEEEEEGGGT CS
     DUF5050 161 ykldtdgksiskvseenlyllvvegdyiYyidlskn 196
                   ++ dg++ ++ s +n ++l+v +d iY+ dl+++
  EFC35903.1 200 EGYNGDGRNATDTSLNNPNSLFVHNDEIYFSDLDNQ 235
                 556667777777777777778888888888887664 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.01
                 TT-EEEETTEEEEE-GGGTT CS
     DUF5050   9 gGlfcekdgkiYFsnpyden 28 
                 +G+f+++ +++YF+  y+++
  EFC35903.1 274 KGIFVDSKNQVYFADYYNHC 293
                 79************988765 PP

>> Plasmo_rep  Plasmodium repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.4    0.0012       3.6       2      12 ..      57      67 ..      56      68 .. 0.89
   2 ?   -2.1   0.2      0.96   2.9e+03      17      20 ..     170     173 ..     165     174 .. 0.67
   3 ?    2.4   0.1      0.04   1.2e+02      15      20 ..     223     228 ..     222     228 .. 0.93

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0012
  Plasmo_rep  2 sDnEvYspkqE 12
                s n+vY++++E
  EFC35903.1 57 SSNQVYISENE 67
                779*******9 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.96
  Plasmo_rep  17 rEIY 20 
                 +EIY
  EFC35903.1 170 DEIY 173
                 5666 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.04
  Plasmo_rep  15 qNrEIY 20 
                 +N+EIY
  EFC35903.1 223 HNDEIY 228
                 7***** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       387  (0.0215851); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2135.15
//
Query:       EFC35904.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.8e-84  281.7  26.7    6.7e-84  281.5  26.7    1.0  1  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  281.5  26.7   3.7e-88   6.7e-84       1     246 [.      20     274 ..      20     277 .. 0.96

  Alignments for each domain:
  == domain 1  score: 281.5 bits;  conditional E-value: 3.7e-88
  PhoLip_ATPase_C   1 vraSDyaiaqFrfLkrLLlvhGrwsyrRisklilyffyKnvvftlvqfwfqfyngfsgqslyeswlltlynllftslpvivlgifdqdvsaell 94 
                      v+aSDyai+qFrfLkrLLlvhGrw+yrR+skl++y+fyKn++f+l+q+wf++yng+sg sl+++w+++lyn++ft lp+++l+ +d+dv++ ++
       EFC35904.1  20 VNASDYAIGQFRFLKRLLLVHGRWNYRRVSKLVVYVFYKNILFFLTQLWFNIYNGYSGASLHDNWTIALYNTIFTGLPIVALAFMDRDVPDYIA 113
                      79******************************************************************************************** PP

  PhoLip_ATPase_C  95 lkyPelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvaletktwtliliililgsi 188
                      +kyPelY +gqkn++fn k f+ wi++++++s+i+ff++y++l ds+f dg++ d q++g++v+++++ v+++k+a+et +wt++++++++g  
       EFC35904.1 114 EKYPELYFQGQKNRYFNAKIFISWIVNAVFHSTICFFIPYYCLVDSKFIDGQDIDTQTIGIAVYSCVLAVTLFKLAIETASWTIVHCLFYFGFY 207
                      *******************************************999999*******************************************99 PP

  PhoLip_ATPase_C 189 llyflflllyssllps.........ssefygvleelfsspsfwlvlllvvvvallpdllikvlkrtf 246
                      l++ +f++ y s++           +++ ++   ++f sp+f+++l+lv ++++l+d+++k + r++
       EFC35904.1 208 LSFPAFVFSYGSVYYLikypypvlsETYSITQRWRIFLSPQFYFILMLVAFACCLRDIFWKGFVRMY 274
                      9******9998888878899999876666666899***************************99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1673.26
//
Query:       EFC35905.1  [L=556]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-17   62.7   0.0    0.00039   20.3   0.0    6.2  6  NHL           NHL repeat
     0.0006   19.8   0.0     0.0028   17.7   0.0    2.0  3  Phytase-like  Esterase-like activity of phytase
     0.0011   18.9   1.2        7.9    6.6   0.1    4.6  3  SBBP          Beta-propeller repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0    0.0034        20       2      16 ..      60      75 ..      59      79 .. 0.91
   2 !   18.0   0.1   3.5e-07    0.0021       1      22 [.      97     118 ..      97     120 .. 0.95
   3 ?   -1.5   0.0      0.52   3.1e+03       4      16 ..     193     205 ..     192     206 .. 0.81
   4 !    9.9   0.0   0.00013      0.76       1      27 [.     246     271 ..     246     272 .. 0.92
   5 ?   -0.6   0.0      0.27   1.6e+03       4      20 ..     305     322 ..     302     325 .. 0.75
   6 !   20.3   0.0   6.5e-08   0.00039       1      27 [.     419     445 ..     419     446 .. 0.94

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0034
                SSEEEEEEE.TTTEEE CS
         NHL  2 nyPhGvavd.snGdiy 16
                ++P G+avd +nG+iy
  EFC35905.1 60 YRPYGLAVDkKNGNIY 75
                5788***********8 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 3.5e-07
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 ++yP ++av++ ++i+++D++n
  EFC35905.1  97 LSYPVCIAVSPKDEIFICDNNN 118
                 78*******************9 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.52
                 EEEEEEETTTEEE CS
         NHL   4 PhGvavdsnGdiy 16 
                 P  ++ dsnG+++
  EFC35905.1 193 PGAIVFDSNGNLF 205
                 7779999999985 PP

  == domain 4  score: 9.9 bits;  conditional E-value: 0.00013
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f yP+G+a+  ++ +yV+D+   r+++
  EFC35905.1 246 FTYPSGLAL-YGNSLYVSDFADYRIRK 271
                 89*******.6*********9999986 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 0.27
                 EEEEEEE.TTTEEEEEEC CS
         NHL   4 PhGvavd.snGdiyVaDs 20 
                 P ++ ++ + ++++V Ds
  EFC35905.1 305 PVSTFYNsKRDELLVVDS 322
                 55555777899******7 PP

  == domain 6  score: 20.3 bits;  conditional E-value: 6.5e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P+G+a++++G+++++D ++h++++
  EFC35905.1 419 LSSPEGIAISTSGEVFISDKGSHTIRK 445
                 679**********************87 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.35   2.1e+03      72     106 ..     155     190 ..     137     230 .. 0.82
   2 ?   -2.9   0.0      0.84     5e+03      49     100 ..     228     279 ..     195     282 .. 0.71
   3 !   17.7   0.0   4.7e-07    0.0028      51     103 ..     402     455 ..     348     471 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.35
  Phytase-like  72 giav.apdgtfwvssEggpfilefdadGkllrelpl 106
                   gia+ + +g++++s+  ++ i+ +  +G+ll+ +++
    EFC35905.1 155 GIAFhPVTGEMYFSDINNNVIRYVASNGTLLTYVSI 190
                   788988999999999999999999999999887766 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.84
  Phytase-like  49 itevtplkdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdad.Gkl 100
                    ++v+ +  + g++++ + + p g+a+  +++++vs+  + +i+++d+  G++
    EFC35905.1 228 NAGVVGFSGDGGSALNARFTYPSGLAL-YGNSLYVSDFADYRIRKIDLVlGNI 279
                   455666666667777666667778888.8888888888888888888766665 PP

  == domain 3  score: 17.7 bits;  conditional E-value: 4.7e-07
  Phytase-like  51 evtplkdpdgapfpkkgl.DpEgiavapdgtfwvssEggpfilefdadGkllre 103
                   ++      dg p +  +l  pEgia++  g++++s+ g + i+++d +G + + 
    EFC35905.1 402 GSQAYSSGDGYPATAARLsSPEGIAISTSGEVFISDKGSHTIRKIDSKGVISNV 455
                   33334444588888888889*****************************98765 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.1    0.0013       7.9      14      29 ..      61      77 ..      47      79 .. 0.77
   2 !    6.2   0.1    0.0017        10      13      28 ..     191     206 ..     181     215 .. 0.78
   3 ?    0.4   0.0      0.12   6.9e+02      14      28 ..     421     435 ..     414     436 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0013
        SBBP 14 ygngIavDs.nGNiYvt 29
                 ++g+avD+ nGNiY +
  EFC35905.1 61 RPYGLAVDKkNGNIYYA 77
                69******64999**75 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0017
        SBBP  13 tygngIavDsnGNiYv 28 
                 +++  I +DsnGN + 
  EFC35905.1 191 VSPGAIVFDSNGNLFA 206
                 67888********986 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.12
        SBBP  14 ygngIavDsnGNiYv 28 
                 ++ gIa+ ++G +++
  EFC35905.1 421 SPEGIAISTSGEVFI 435
                 699********9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (556 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       408  (0.0227564); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.50
# Mc/sec: 3333.03
//
Query:       EFC35906.1  [L=728]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.1e-43  142.5   7.8    1.3e-06   28.1   0.0    6.9  6  NHL             NHL repeat
    5.4e-11   42.7   0.4        4.6    7.7   0.0    6.6  6  Linker_histone  linker histone H1 and H5 family
    2.6e-10   40.5   2.7    2.6e-10   40.5   0.3    2.3  3  BTB             BTB/POZ domain
    8.6e-08   32.1   0.0        1.1    8.8   0.0    4.5  4  SGL             SMP-30/Gluconolactonase/LRE-like region
    0.00029   20.6   3.1         89    3.1   0.0    6.5  7  DUF1236         Protein of unknown function (DUF1236)
    0.00047   19.6  27.2        4.2    7.0   0.2    7.0  7  Plasmo_rep      Plasmodium repeat family
    0.00056   19.1   1.4        5.6    5.9   0.1    4.0  5  Coatomer_WDAD   Coatomer WD associated region
      0.001   19.8   5.1    2.5e+02    2.5   0.0    6.3  6  MJ1316          MJ1316 RNA cyclic group end recognition domai
  ------ inclusion threshold ------
       0.15   11.8   0.9        5.9    6.6   0.0    3.6  4  PCMT            Protein-L-isoaspartate(D-aspartate) O-methylt


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.2   0.0   5.4e-09   1.1e-05       1      27 [.      10      36 ..      10      37 .. 0.94
   2 !   27.1   0.1   1.4e-09   2.7e-06       1      27 [.      66      92 ..      66      93 .. 0.95
   3 !   17.8   0.1   1.2e-06    0.0025       1      27 [.     122     148 ..     122     149 .. 0.95
   4 !   28.1   0.0   6.7e-10   1.3e-06       1      27 [.     178     204 ..     178     205 .. 0.95
   5 !   17.8   0.1   1.2e-06    0.0025       1      27 [.     234     260 ..     234     261 .. 0.95
   6 !   25.3   0.0   5.2e-09     1e-05       1      27 [.     290     316 ..     290     317 .. 0.95

  Alignments for each domain:
  == domain 1  score: 25.2 bits;  conditional E-value: 5.4e-09
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +++P++v v+sn+++y+aD++nhr+++
  EFC35906.1 10 LYSPESVFVSSNNEVYIADYGNHRIRK 36
                689**********************97 PP

  == domain 2  score: 27.1 bits;  conditional E-value: 1.4e-09
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +n P Gv v+sn+++y+aD+ nhr+++
  EFC35906.1 66 LNGPVGVFVSSNNEVYIADYDNHRIRK 92
                799**********************97 PP

  == domain 3  score: 17.8 bits;  conditional E-value: 1.2e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P++v v+sn+++y+aD  nhr+++
  EFC35906.1 122 LNFPRCVFVSSNNEVYIADQINHRIRK 148
                 79***********************87 PP

  == domain 4  score: 28.1 bits;  conditional E-value: 6.7e-10
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+Gv v+sn++iy+aD+ nhr+++
  EFC35906.1 178 LNSPAGVFVSSNNEIYIADYDNHRIRK 204
                 799**********************97 PP

  == domain 5  score: 17.8 bits;  conditional E-value: 1.2e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P++v v+sn+++y+aD  nhr+++
  EFC35906.1 234 LNFPRCVFVSSNNEVYIADQINHRIRK 260
                 79***********************87 PP

  == domain 6  score: 25.3 bits;  conditional E-value: 5.2e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+Gv v+sn++iy+a+++nhr+++
  EFC35906.1 290 LNSPAGVFVSSNNEIYIAEYGNHRIRK 316
                 799**********************97 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.027        53      43      69 ..      27      53 ..      16      56 .. 0.81
   2 ?    3.5   0.0     0.047        94      44      69 ..      84     109 ..      71     112 .. 0.82
   3 !    7.7   0.0    0.0023       4.6      40      69 ..     136     165 ..     128     167 .. 0.83
   4 ?    4.8   0.0     0.019        37      46      69 ..     198     221 ..     185     224 .. 0.83
   5 !    7.7   0.0    0.0023       4.6      40      69 ..     248     277 ..     240     279 .. 0.83
   6 ?    5.6   0.0      0.01        21      42      69 ..     306     333 ..     296     336 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.027
  Linker_histone 43 ksllkkalkkgvekgelvqpkgkGasG 69
                    + + ++ ++k +e+g +v + g+G++G
      EFC35906.1 27 ADYGNHRIRKILENGNIVTIAGNGTAG 53
                    5667899***************99988 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.047
  Linker_histone  44 sllkkalkkgvekgelvqpkgkGasG 69 
                      + ++ ++k +e+g +v + gkG++G
      EFC35906.1  84 DYDNHRIRKILENGNIVIIAGKGTAG 109
                     555889***************99988 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0023
  Linker_histone  40 skfksllkkalkkgvekgelvqpkgkGasG 69 
                       ++ ++++ ++k +e+g +v + g+G+ G
      EFC35906.1 136 VYIADQINHRIRKILENGNIVTIAGNGPYG 165
                     356889*********************987 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.019
  Linker_histone  46 lkkalkkgvekgelvqpkgkGasG 69 
                      ++ ++k +e+g +v + gkG++G
      EFC35906.1 198 DNHRIRKILENGNIVTIAGKGTAG 221
                     5889***************99998 PP

  == domain 5  score: 7.7 bits;  conditional E-value: 0.0023
  Linker_histone  40 skfksllkkalkkgvekgelvqpkgkGasG 69 
                       ++ ++++ ++k +e+g +v + g+G+ G
      EFC35906.1 248 VYIADQINHRIRKILENGNIVTIAGNGPYG 277
                     356889*********************987 PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.01
  Linker_histone  42 fksllkkalkkgvekgelvqpkgkGasG 69 
                     ++ + ++ ++k +e+g +v + g+G++G
      EFC35906.1 306 IAEYGNHRIRKILENGNIVTVAGNGTAG 333
                     56677999***************99988 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       2.5     5e+03      62      92 ..     408     439 ..     394     451 .. 0.69
   2 ?   -3.0   0.0       4.2   8.4e+03      75      98 ..     465     488 ..     457     498 .. 0.71
   3 !   40.5   0.3   1.3e-13   2.6e-10       3     106 ..     555     660 ..     553     664 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.5
                 HHHHHHHHHHHHSEEEC-.CGGGHHHHHHHHH CS
         BTB  62 eafealLefiYtgeleit.seenleelLaaad 92 
                 e++++l++ +  ++ +++ ++e++ ++L +  
  EFC35906.1 408 EIIQKLIDSLIYDKNKVKfNKEEMLDVLFILG 439
                 67777777776666666666777777776555 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.2
                 EEEC-CGGGHHHHHHHH.HHHT-HH CS
         BTB  75 eleitseenleelLaaa.dllqipr 98 
                 +l+++ +e++e+lL++  + +++++
  EFC35906.1 465 NLTFK-WETIENLLKICnEEFNVQN 488
                 45564.7788888877766666654 PP

  == domain 3  score: 40.5 bits;  conditional E-value: 1.3e-13
                 HHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST....TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-H CS
         BTB   3 elresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk....eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqip 97 
                 +l + ++ +Dv +++g++k +++hk +L + S+ F+alf s+      ++++    + +  + e +e++++++Y   ++i+ + ++  lL++  + +i+
  EFC35906.1 555 SLYNDKKTSDVKIKMGQDKYLYCHKTILTSFSTLFNALFDSGscfsDLSDDGI-FTPDESEDLELLEIVIKYCYGISIDID-DVKIIGLLEMVTKHEIQ 651
                 6788899***********************************76543344443.3555777889****************7.***************** PP

                 HHHHHHHHH CS
         BTB  98 rlkkaceef 106
                  +++ c++ 
  EFC35906.1 652 YVIDYCKNN 660
                 ******976 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.0    0.0095        19     185     218 ..      12      45 ..       3      52 .. 0.87
   2 ?    4.4   0.0     0.012        24     184     216 ..      67      99 ..      48     103 .. 0.84
   3 !    7.9   0.0     0.001       2.1     145     218 ..     133     213 ..     127     217 .. 0.78
   4 !    8.8   0.0   0.00053       1.1     145     218 ..     245     325 ..     231     329 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0095
         SGL 185 epDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                  p +++v ++++v++A +g+++++++ ++G++++
  EFC35906.1  12 SPESVFVSSNNEVYIADYGNHRIRKILENGNIVT 45 
                 488999***********************99875 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.012
         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                 + p G++v ++++v++A +++++++++ ++G++
  EFC35906.1  67 NGPVGVFVSSNNEVYIADYDNHRIRKILENGNI 99 
                 34889**********************999986 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.001
         SGL 145 gktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 ++ +Y+aD  +++i ++  + +  ++    ++ +++++g       + p G++v +++++++A +++++++++ ++G++++
  EFC35906.1 133 NNEVYIADQINHRIRKILENGNIVTIAGNGPYgFCGDNGLatnaqlNSPAGVFVSSNNEIYIADYDNHRIRKILENGNIVT 213
                 6677777777777777777776666666666656666666777777679***************************99875 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.00053
         SGL 145 gktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 ++ +Y+aD  +++i ++  + +  ++    ++ +++++g       + p G++v +++++++A +g+++++++ ++G++++
  EFC35906.1 245 NNEVYIADQINHRIRKILENGNIVTIAGNGPYgFCGDNGLatnaqlNSPAGVFVSSNNEIYIAEYGNHRIRKILENGNIVT 325
                 667788888888888877777777776666665666666688777767****************************99875 PP

>> DUF1236  Protein of unknown function (DUF1236)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.045        89      39      64 ..      13      38 ..       7      39 .. 0.84
   2 ?    1.6   0.1      0.13   2.5e+02      43      64 ..      73      94 ..      71      95 .. 0.87
   3 ?    1.6   0.0      0.13   2.5e+02      42      64 ..     128     150 ..     120     151 .. 0.84
   4 ?    2.7   0.0     0.057   1.1e+02      43      64 ..     185     206 ..     178     207 .. 0.88
   5 ?    1.6   0.0      0.13   2.5e+02      42      64 ..     240     262 ..     232     263 .. 0.84
   6 ?    2.0   0.0     0.096   1.9e+02      43      64 ..     297     318 ..     290     319 .. 0.88
   7 ?   -0.7   0.0      0.69   1.4e+03      12      36 ..     691     716 ..     688     724 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.045
     DUF1236 39 peyrYvvvndrtviVdpqtrriVevi 64
                pe  +v  n++++i d +++ri +++
  EFC35906.1 13 PESVFVSSNNEVYIADYGNHRIRKIL 38
                6777999**************97776 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.13
     DUF1236 43 YvvvndrtviVdpqtrriVevi 64
                +v  n++++i d +++ri +++
  EFC35906.1 73 FVSSNNEVYIADYDNHRIRKIL 94
                7888*************97776 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.13
     DUF1236  42 rYvvvndrtviVdpqtrriVevi 64 
                  +v  n++++i d+ ++ri +++
  EFC35906.1 128 VFVSSNNEVYIADQINHRIRKIL 150
                 58999*************97776 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.057
     DUF1236  43 YvvvndrtviVdpqtrriVevi 64 
                 +v  n++++i d +++ri +++
  EFC35906.1 185 FVSSNNEIYIADYDNHRIRKIL 206
                 7889*************97776 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.13
     DUF1236  42 rYvvvndrtviVdpqtrriVevi 64 
                  +v  n++++i d+ ++ri +++
  EFC35906.1 240 VFVSSNNEVYIADQINHRIRKIL 262
                 58999*************97776 PP

  == domain 6  score: 2.0 bits;  conditional E-value: 0.096
     DUF1236  43 YvvvndrtviVdpqtrriVevi 64 
                 +v  n++++i + +++ri +++
  EFC35906.1 297 FVSSNNEIYIAEYGNHRIRKIL 318
                 7889*************97776 PP

  == domain 7  score: -0.7 bits;  conditional E-value: 0.69
     DUF1236  12 vveeevsvGaalPet.VelrpvPdev 36 
                 +v ++++ G++l ++  e+  +P++v
  EFC35906.1 691 IVTFSMVNGKQLFRDrTEISKLPEKV 716
                 57899999****99999******985 PP

>> Plasmo_rep  Plasmodium repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       4.1   8.2e+03       5      10 ..       9      14 ..       9      14 .. 0.90
   2 !    5.6   0.1    0.0057        11       1      10 [.      19      28 ..      19      30 .. 0.84
   3 !    5.2   0.3    0.0075        15       1      10 [.      75      84 ..      75      86 .. 0.85
   4 !    7.0   0.2    0.0021       4.2       1      11 [.     131     141 ..     131     143 .. 0.88
   5 !    5.2   0.4     0.008        16       1      10 [.     187     196 ..     187     198 .. 0.82
   6 !    7.0   0.2    0.0021       4.2       1      11 [.     243     253 ..     243     255 .. 0.88
   7 !    5.9   0.2    0.0047       9.5       1      11 [.     299     309 ..     299     310 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.1
  Plasmo_rep  5 EvYspk 10
                ++Ysp+
  EFC35906.1  9 QLYSPE 14
                89***8 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0057
  Plasmo_rep  1 FsDnEvYspk 10
                +s+nEvY+ +
  EFC35906.1 19 SSNNEVYIAD 28
                69*****977 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0075
  Plasmo_rep  1 FsDnEvYspk 10
                +s+nEvY+ +
  EFC35906.1 75 SSNNEVYIAD 84
                69*****976 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0021
  Plasmo_rep   1 FsDnEvYspkq 11 
                 +s+nEvY+ +q
  EFC35906.1 131 SSNNEVYIADQ 141
                 69******998 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.008
  Plasmo_rep   1 FsDnEvYspk 10 
                 +s+nE+Y+ +
  EFC35906.1 187 SSNNEIYIAD 196
                 69*****966 PP

  == domain 6  score: 7.0 bits;  conditional E-value: 0.0021
  Plasmo_rep   1 FsDnEvYspkq 11 
                 +s+nEvY+ +q
  EFC35906.1 243 SSNNEVYIADQ 253
                 69******998 PP

  == domain 7  score: 5.9 bits;  conditional E-value: 0.0047
  Plasmo_rep   1 FsDnEvYspkq 11 
                 +s+nE+Y+ ++
  EFC35906.1 299 SSNNEIYIAEY 309
                 69*****9775 PP

>> Coatomer_WDAD  Coatomer WD associated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.022        43      42      93 ..      39      90 ..      31     103 .. 0.80
   2 ?   -0.3   0.0      0.21   4.1e+02      42      92 ..      95     145 ..      91     151 .. 0.80
   3 !    5.4   0.0    0.0039       7.8      42      93 ..     151     202 ..     141     217 .. 0.77
   4 ?    0.3   0.0      0.14   2.7e+02      42      93 ..     207     258 ..     201     264 .. 0.81
   5 !    5.9   0.1    0.0028       5.6      41      93 ..     262     314 ..     240     329 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.022
                   XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Coatomer_WDAD 42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvki 93
                   +ng++v++ g+g+  +    +  +ka+ +g   v+vssn+ +++ +  + +i
     EFC35906.1 39 ENGNIVTIAGNGTAGFSGDNGIATKAQLNGPVGVFVSSNNEVYIADYDNHRI 90
                   799**********************************776554444444444 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.21
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Coatomer_WDAD  42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvk 92 
                    +ng++v++ g+g+  +    +l +k++ +    v+vssn+ +++ ++ + +
     EFC35906.1  95 ENGNIVIIAGKGTAGFSGDNGLATKEKLNFPRCVFVSSNNEVYIADQINHR 145
                    6999*********************************66644444444433 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0039
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXX CS
  Coatomer_WDAD  42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnr.favlessksvki 93 
                    +ng++v++ g+g y ++   +l ++a+ ++   v+vssn+ + + +   + +i
     EFC35906.1 151 ENGNIVTIAGNGPYGFCGDNGLATNAQLNSPAGVFVSSNNeIYIAD-YDNHRI 202
                    79***********************************665233333.333333 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.14
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Coatomer_WDAD  42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvki 93 
                    +ng++v++ g+g+  +    +l +k++ +    v+vssn+ +++ ++ + +i
     EFC35906.1 207 ENGNIVTIAGKGTAGFSGDNGLATKEKLNFPRCVFVSSNNEVYIADQINHRI 258
                    799**********************************666555555444444 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.0028
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Coatomer_WDAD  41 npngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvki 93 
                     +ng++v++ g+g y ++   +l ++a+ ++   v+vssn+  ++ + ++ +i
     EFC35906.1 262 LENGNIVTIAGNGPYGFCGDNGLATNAQLNSPAGVFVSSNNEIYIAEYGNHRI 314
                    579***********************************776555555555555 PP

>> MJ1316  MJ1316 RNA cyclic group end recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0      0.13   2.5e+02      60      73 ..      31      44 ..      12      45 .. 0.88
   2 ?    2.5   0.0      0.13   2.5e+02      61      73 ..      88     100 ..      73     101 .. 0.89
   3 ?    2.4   0.0      0.14   2.7e+02      61      73 ..     144     156 ..     124     157 .. 0.90
   4 ?    2.5   0.0      0.13   2.5e+02      61      73 ..     200     212 ..     181     213 .. 0.88
   5 ?    2.4   0.0      0.14   2.7e+02      61      73 ..     256     268 ..     236     269 .. 0.90
   6 ?    2.5   0.0      0.13   2.5e+02      60      73 ..     311     324 ..     293     325 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.13
      MJ1316 60 lHRiryikrkgevv 73
                 HRir+i  +g++v
  EFC35906.1 31 NHRIRKILENGNIV 44
                5**********998 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.13
      MJ1316  61 HRiryikrkgevv 73 
                 HRir+i  +g++v
  EFC35906.1  88 HRIRKILENGNIV 100
                 **********998 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.14
      MJ1316  61 HRiryikrkgevv 73 
                 HRir+i  +g++v
  EFC35906.1 144 HRIRKILENGNIV 156
                 **********998 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.13
      MJ1316  61 HRiryikrkgevv 73 
                 HRir+i  +g++v
  EFC35906.1 200 HRIRKILENGNIV 212
                 **********998 PP

  == domain 5  score: 2.4 bits;  conditional E-value: 0.14
      MJ1316  61 HRiryikrkgevv 73 
                 HRir+i  +g++v
  EFC35906.1 256 HRIRKILENGNIV 268
                 **********998 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.13
      MJ1316  60 lHRiryikrkgevv 73 
                  HRir+i  +g++v
  EFC35906.1 311 NHRIRKILENGNIV 324
                 5**********998 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.9   3.7e+03     106     138 ..      22      55 ..       6      62 .. 0.71
   2 ?   -1.5   0.0      0.85   1.7e+03      92     138 ..      64     111 ..      55     113 .. 0.76
   3 ?    6.6   0.0     0.003       5.9      97     145 ..     293     342 ..     242     346 .. 0.85
   4 ?    0.7   0.0      0.19   3.8e+02      88     131 ..     526     570 ..     524     579 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.9
                 SBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 106 rikelveeakrnlkkldle.nvivvvgDGrkGye 138
                     +++  +++++k   + n++++ g G+ G+ 
  EFC35906.1  22 NEVYIADYGNHRIRKILENgNIVTIAGNGTAGFS 55 
                 4555566667777775444599999****99996 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.85
                 HHHHCTTCEEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT  92 arlvgekgrvvsierikelveeakrnlkkldle.nvivvvgDGrkGye 138
                 a+l g++g  vs +    +++  +++++k   + n++++ g G+ G+ 
  EFC35906.1  64 AQLNGPVGVFVSSNNEVYIADYDNHRIRKILENgNIVIIAGKGTAGFS 111
                 5666777777777777777778888888865556***********985 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.003
                 TTCEEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTGGG-SEEE CS
        PCMT  97 ekgrvvsierikelveeakrnlkkldle.nvivvvgDGrkGyeekaPYda 145
                 + g  vs +    ++e  +++++k   + n+++v g G+ G+   +P+d 
  EFC35906.1 293 PAGVFVSSNNEIYIAEYGNHRIRKILENgNIVTVAGNGTAGFSGDSPFDI 342
                 55666666666677788888998865556*******************95 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.19
                 HHHHHHHHCTTCEEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES CS
        PCMT  88 tavlarlvgekgrvvsierikelveeakrnlkkldle.nvivvvg 131
                 ta++++++ ++ +++ ie + e   +  + l +++ + +v++++g
  EFC35906.1 526 TAIFSKMIITQPTAINIEETIETEPQIIESLYNDKKTsDVKIKMG 570
                 9****************9988887777777766554437777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (728 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       604  (0.0336884); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.76u 0.29s 00:00:01.05 Elapsed: 00:00:00.51
# Mc/sec: 4271.52
//
Query:       EFC35907.1  [L=294]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-32  111.6   0.0    1.4e-17   63.9   0.0    2.3  2  adh_short        short chain dehydrogenase
    1.4e-19   70.6   0.0    5.7e-11   42.4   0.0    2.1  2  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
    6.9e-09   35.9   0.0    2.7e-07   30.7   0.0    2.1  2  KR               KR domain
  ------ inclusion threshold ------
      0.025   13.7   0.6      0.052   12.7   0.1    1.7  2  Polysacc_synt_2  Polysaccharide biosynthesis protein


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.9   0.0     3e-21   1.4e-17       1     104 [.      18     123 ..      18     128 .. 0.94
   2 !   46.3   0.0   7.2e-16   3.2e-12     126     190 ..     125     193 ..     122     198 .. 0.91

  Alignments for each domain:
  == domain 1  score: 63.9 bits;  conditional E-value: 3e-21
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT.TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGGCSH CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee.gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfselse 98 
                 +v+++ GassGIGr +a +lak   ++v+++r++++le+v ke+  + + + l++++Dvt++++v++ +e ++ k+++++ L  +AGi+gs pf e+++
  EFC35907.1  18 NVIVISGASSGIGRGLALQLAKFKTNIVLIARTKSALEQVSKECLLNgALSTLILPCDVTNEDQVKNSIELIKIKYKEINQLFLCAGISGSIPFIEIED 116
                 689******************************************998899************************************************ PP

                 HH.HHHH CS
   adh_short  99 ee.werv 104
                  + +e++
  EFC35907.1 117 MKiFEQI 123
                 **66654 PP

  == domain 2  score: 46.3 bits;  conditional E-value: 7.2e-16
                 CTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGT....EEEEEEEESSBSSHHHHHH CS
   adh_short 126 qssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakelaptg....irvnavaPGlvdTdmakel 190
                 +++ +I  +sS+ g  p +  +aY+ sK+av+g++r+l+ el++t      +++ ++PG vdT+++k  
  EFC35907.1 125 SNNSHITVISSMSGIIPIPLRTAYCMSKFAVEGFFRTLRSELKNTPkyshLTITLICPGWVDTEIRKHH 193
                 5677899***********************************99877788**************99865 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.4   0.0   1.3e-14   5.7e-11       1      93 [.      24     117 ..      24     126 .. 0.82
   2 !   27.2   0.0   5.8e-10   2.6e-06     114     188 ..     121     199 ..     117     217 .. 0.81

  Alignments for each domain:
  == domain 1  score: 42.4 bits;  conditional E-value: 1.3e-14
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGHHHHHHHHHHHTT..SE.EEE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH-HH CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneeakkrveelaeelg..ae.vlecDVtdeeqvealveevvekfgklDilvnnagiapklkgpfletsre 93 
                   Ga sgIGr++A +la+   ++vl  + ++a ++v +     g  ++ +l+cDVt+e+qv++ +e ++ k+++++ l+ +agi+ +   pf+e+++ 
    EFC35907.1  24 GASSGIGRGLALQLAKFKTNIVLIARTKSALEQVSKECLLNGalSTlILPCDVTNEDQVKNSIELIKIKYKEINQLFLCAGISGS--IPFIEIEDM 117
                   899**************************9555555444334234446************************************9..999998543 PP

  == domain 2  score: 27.2 bits;  conditional E-value: 5.8e-10
                   HHHCTSCCEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHHHGG....GTEEEEEEEE--BHCTGGGGSTTHHHH CS
  adh_short_C2 114 lplmkeggsivnlssvgaervvpnynaygaaKaalealtrylAvelgp....kgiRvNavspgpikTlaasgikgfdel 188
                   +++  +++ i  +ss+++ + +p  +ay+++K a+e++ r+l  el +       ++  ++pg+++T++ ++   +++ 
    EFC35907.1 121 EQINSNNSHITVISSMSGIIPIPLRTAYCMSKFAVEGFFRTLRSELKNtpkySHLTITLICPGWVDTEIRKHHLTEHQT 199
                   556677899999**********************************985566799*************97766544444 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.7   0.0     6e-11   2.7e-07       3     101 ..      20     115 ..      18     125 .. 0.82
   2 ?    3.4   0.0     0.014        63     127     166 ..     126     165 ..     117     173 .. 0.83

  Alignments for each domain:
  == domain 1  score: 30.7 bits;  conditional E-value: 6e-11
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE---------TTT-- CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvlrdklleemt 101
                  +i G+  g+G+ la +la+  ++++vl++R+++a e+ +   + l +   +  ++++Dv+++d+v++ +e ik + ++i+  + +Ag++   ++ e +
  EFC35907.1  20 IVISGASSGIGRGLALQLAK-FKTNIVLIARTKSALEQVS--KECLLNGALSTLILPCDVTNEDQVKNSIELIKIKYKEINQLFLCAGISGSIPFIEIE 115
                 689***************85.689********44444333..34444445589999*********************************9887776655 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.014
                 --SEEEEEEEHHHHH--TT-HHHHHHHHHHHHHHHHHHHH CS
          KR 127 sldffvlfSSiagllgsagqanYaaaNaflDalaeyrrsq 166
                 +  +++++SS++g++  + +++Y      ++++ ++ rs+
  EFC35907.1 126 NNSHITVISSMSGIIPIPLRTAYCMSKFAVEGFFRTLRSE 165
                 5567899****************99999999988877765 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1   1.2e-05     0.052       1      79 [.      20      92 ..      20     132 .. 0.82
   2 ?   -1.5   0.0      0.25   1.1e+03     203     248 ..     209     254 ..     201     267 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.2e-05
                     EEEETTTSHHHHHHHHHHHHHB-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT..T-S CS
  Polysacc_synt_2  1 vlvtGagGsiGselvrqilkkkpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrdkerlekaleelkvd 79
                     ++++Ga+  iG+ l  q++k+k  +i+l+ r+  +l +++ke+  +     l  +++ + +dv++++++++ +e +k++
       EFC35907.1 20 IVISGASSGIGRGLALQLAKFKT-NIVLIARTKSALEQVSKECLLNG---AL--STLILPCDVTNEDQVKNSIELIKIK 92
                     78******************986.68999999**********74333...34..3334569*********999876654 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.25
                      EE-HHHHHHHHHHHHHH--SS-EEEE--.-EEEHHHHHHHH..... CS
  Polysacc_synt_2 203 fmtieeavqLvlqalalakggeifvldmGepvkivdlakalielsg 248
                      +mti+e v   l+a+ + k  + f l    +  i+d++ ++ie + 
       EFC35907.1 209 MMTIDECVLKTLNAVRMKKYTQRFKLLYQFAPIIYDIVPSIIENMT 254
                      6788888888888888777777665555445556666666665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (294 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       855  (0.0476881); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1775.54
//
Query:       EFC35908.1  [L=312]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.7e-64  211.7   3.5    3.8e-22   78.0   0.0    3.0  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.0   0.0   2.1e-26   3.8e-22       4      96 ..       8     105 ..       5     106 .. 0.92
   2 !   70.1   0.0   6.1e-24   1.1e-19       5      91 ..     115     200 ..     112     205 .. 0.94
   3 !   63.3   0.2     8e-22   1.4e-17       4      93 ..     212     301 ..     209     304 .. 0.93

  Alignments for each domain:
  == domain 1  score: 78.0 bits;  conditional E-value: 2.1e-26
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS......HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCTT CS
   Mito_carr   4 svlkellaGglagavatlvttPldvvKtrlqtqkksskksksaa......ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllkk 96 
                  +++++++Gg++gava+++t+P+++vK  +qtq  + + +   +      i++++ ++  e+G+++++rG+  n++r++p++a +f++ +++k+++ k+
  EFC35908.1   8 AFVRDFAIGGASGAVAKTLTAPIERVKLLIQTQDANPRIRSG-EiprytgIANCFTRVASEQGIAAFWRGNFTNVIRYFPTQAFNFAFKDSIKKIFPKY 105
                 5899*****************************999876543.3588899*********************************************9986 PP

  == domain 2  score: 70.1 bits;  conditional E-value: 6.1e-24
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHH.HHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiyk.eeGlrglyrGllpnllrvapasalkfvlyetlkr 91 
                 +l +l++Gglaga++ ++++Pld+++trl ++ ++++   +++++d+l k+ k   G++gly G+++++ +++p+++++f+ly++l++
  EFC35908.1 115 FLVQLASGGLAGAGSLCIVYPLDYARTRLASDVGKERV--FNGLADCLAKTAKgPAGFMGLYNGFGVSVAGIIPYRGVYFGLYDSLRE 200
                 6789****************************999876..778**********889****************************9986 PP

  == domain 3  score: 63.3 bits;  conditional E-value: 8e-22
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS.HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   4 svlkellaGglagavatlvttPldvvKtrlqtqkksskksksaa.ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrll 93 
                 +++++++++ + +++a+ + +P+d+v+ rlq+q+++ k++  ++ ++d++ ki+keeG  ++++G+++n lr++  sal +vly++l+ +l
  EFC35908.1 212 GIISKFAVAQTTAIAAGYASYPFDTVRRRLQMQSEKPKDQWLYKgTADCFTKILKEEGTQAMFKGAGANALRTV-GSALVLVLYDQLQGML 301
                 5778999999**************************999876667*****************************.***********99887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (312 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       324  (0.0180713); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1958.16
//
Query:       EFC35909.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0059   15.7   0.9     0.0059   15.7   0.9    1.4  2  Trp_Tyr_perm   Tryptophan/tyrosine permease family
  ------ inclusion threshold ------
       0.24   11.5   4.4        2.6    8.2   0.2    2.4  2  Suv3_N         Suv3 helical N-terminal domain


Domain annotation for each model (and alignments):
>> Trp_Tyr_perm  Tryptophan/tyrosine permease family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.9   6.6e-07    0.0059      10      54 ..     116     160 ..     110     180 .. 0.70
   2 ?   -3.4   0.1      0.42   3.8e+03      34      60 ..     288     314 ..     283     337 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 6.6e-07
  Trp_Tyr_perm  10 lliagtviGaGmlalPvatagagfip..sllllilswvlmlasglll 54 
                   ++  +t+ G G+l+lPv+  ++gf p  +++++++++  m+  +++l
    EFC35909.1 116 FISVATILGTGILGLPVKLYRTGFWPffTTFIICFIMQAMI--IIYL 160
                   67789*************99888755115665555555444..4444 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.42
  Trp_Tyr_perm  34 ipsllllilswvlmlasgllllEvlla 60 
                   +  +llli++ ++ + s l  lE + +
    EFC35909.1 288 FKGTLLLIMVGLVGFISNLTNLEFVDK 314
                   556777777777777777777776655 PP

>> Suv3_N  Suv3 helical N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.2   0.00029       2.6      35      96 ..     112     173 ..      86     181 .. 0.74
   2 ?    4.4   0.8    0.0044        40      18      85 ..     206     275 ..     191     290 .. 0.59

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00029
                 HHHHHH-HHHHHHHHH.TT--HHHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHCTSS-GGGG CS
      Suv3_N  35 LneFlrrkaireLake.nGldeklfleafksFRklclesksldvdlhillsDilkgkkdvddl 96 
                 Ln F+ + a   L++   Gl  kl+ + f  F ++ +    +++ + i+l Dil++++ + +l
  EFC35909.1 112 LNTFFISVAT-ILGTGiLGLPVKLYRTGFWPFFTTFIICFIMQAMIIIYLTDILQKTEFIMKL 173
                 5655544333.34433169************************************99877766 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0044
                 ----------HH.HHHHHHHHHHH-HHHHHHHHHTT--HHHHHHHHH.HHHHHHHH-..SS--HHHHHHHHH CS
      Suv3_N  18 vgeeltekldke.eiskvLneFlrrkaireLakenGldeklfleafk.sFRklcles..ksldvdlhillsD 85 
                  + e +++++++ e +++++e ++ ++i ++ ++n   +++  +  + +  ++++e+   + d+dlhi+l D
  EFC35909.1 206 NNLENNNNIENNlEEIEMIEEQVNENQIEDIVNDNN--NQINNQINNeNNNTIIIEQeePVFDPDLHIILGD 275
                 333444444332133445677788889999988873..444444433033445555533578********99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2653  (0.147973); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 2060.57
//
Query:       EFC35910.1  [L=364]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.016   14.9   0.4        8.8    6.0   0.0    3.0  3  Neurensin   Neurensin
      0.037   14.2   1.8       0.12   12.6   0.2    2.3  2  DUF4040     Domain of unknown function (DUF4040)
      0.066   12.9   0.0        1.7    8.3   0.0    2.5  3  DUF4131     Domain of unknown function (DUF4131)
      0.077   12.9   3.5        1.7    8.6   0.1    3.4  3  DUF4083     Domain of unknown function (DUF4083)
       0.33   11.0   0.1       0.33   11.0   0.1    3.5  5  COPI_assoc  COPI associated protein
       0.39   10.6   3.8        0.4   10.6   0.0    2.6  3  DUF2721     Protein of unknown function (DUF2721)
        4.9    7.9   8.7        5.7    7.7   0.0    3.7  4  DUF3139     Protein of unknown function (DUF3139)


Domain annotation for each model (and alignments):
>> Neurensin  Neurensin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.36   9.3e+02     101     125 ..      45      69 ..      33      77 .. 0.73
   2 ?    5.3   0.0    0.0057        15      34      68 ..     114     157 ..      68     183 .. 0.71
   3 ?    6.0   0.0    0.0034       8.8      44      78 ..     285     319 ..     242     329 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.36
   Neurensin 101 vllclGglllalsllvpalsksdkk 125
                 ++l +G +ll +++++ + ++++ +
  EFC35910.1  45 IILFIGTILLGVCIFIRIYQRNEIN 69 
                 5566788888888888887776655 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0057
   Neurensin  34 qksesllwkv..........slvvgtlvlllGvtallvGylvprr 68 
                  + + ++w++           + +g+l  +lG+ +l + +l+p  
  EFC35910.1 114 MSYPTTCWRIphsnqernatHMKSGILSFILGLGCL-IAFLIPMS 157
                 456788999999999999996677777777777765.45666543 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0034
   Neurensin  44 slvvgtlvlllGvtallvGylvprrlelvksegel 78 
                  +++g+l+ ++G+++  +G  +++ l  + s++ +
  EFC35910.1 285 GISLGLLFFIFGIVCFFMGRNLSQDLPQYTSNNTI 319
                 6899*************998888877777665555 PP

>> DUF4040  Domain of unknown function (DUF4040)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.45   1.2e+03      17      36 ..     135     154 ..     130     156 .. 0.84
   2 ?   12.6   0.2   4.6e-05      0.12       7      38 ..     265     296 ..     261     296 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.45
     DUF4040  17 laavillgvvGllvallfvl 36 
                 +++ il+ ++Gl++ ++f++
  EFC35910.1 135 MKSGILSFILGLGCLIAFLI 154
                 677799999****9999985 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 4.6e-05
     DUF4040   7 alaavlardrlaavillgvvGllvallfvllg 38 
                 a a+++++d l  v+++g +G+ + llf+++g
  EFC35910.1 265 AGAVIFVPDILETVVATGSCGISLGLLFFIFG 296
                 899**************************996 PP

>> DUF4131  Domain of unknown function (DUF4131)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0     0.079     2e+02      30      56 ..      43      67 ..       6      90 .. 0.61
   2 ?   -2.9   0.0       1.8   4.5e+03      35      43 ..     143     151 ..     122     159 .. 0.61
   3 ?    8.3   0.0   0.00066       1.7      35      86 ..     287     338 ..     268     360 .. 0.72

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.079
     DUF4131 30 rrvllllllllllallgfalrapqpna 56
                +   ++l++  +l+++++++r +q+n+
  EFC35910.1 43 P--SIILFIGTILLGVCIFIRIYQRNE 67
                3..344444444444444444444444 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.8
     DUF4131  35 lllllllla 43 
                 +l+l +l+a
  EFC35910.1 143 ILGLGCLIA 151
                 111111111 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00066
     DUF4131  35 llllllllallgfalrapqpnandlsqllesgqeviveGvv..aslpeltgsgt 86 
                 +l+ ll+++++ +++   ++ ++dl+q+++ ++++ v   v   +lpe++ ++t
  EFC35910.1 287 SLG-LLFFIFGIVCFFMGRNLSQDLPQYTS-NNTIPVISSVmmNELPEQNQNST 338
                 445.55555555555556666669*****9.66666555555599999998887 PP

>> DUF4083  Domain of unknown function (DUF4083)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.4      0.17   4.4e+02       5      18 ..       3      16 ..       1      20 [. 0.76
   2 ?    8.6   0.1   0.00067       1.7       5      36 ..      39      70 ..      36      84 .. 0.69
   3 ?    1.6   0.0      0.11   2.7e+02      12      43 ..     288     319 ..     285     320 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.17
     DUF4083  5 liyliivivLilll 18
                +i++i++ +L+ll+
  EFC35910.1  3 TIFQIMISLLVLLV 16
                79999888887775 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00067
     DUF4083  5 liyliivivLilllvfsftlfiRrvvsrsaak 36
                ++++  +i+ i+ ++ ++ +fiR        +
  EFC35910.1 39 MLITPSIILFIGTILLGVCIFIRIYQRNEINS 70
                7888889***************9654443334 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.11
     DUF4083  12 ivLilllvfsftlfiRrvvsrsaakkkkskel 43 
                 ++L+  +++ + +f+ r +s+   ++++++ +
  EFC35910.1 288 LGLLFFIFGIVCFFMGRNLSQDLPQYTSNNTI 319
                 67788888888999*99999988888888765 PP

>> COPI_assoc  COPI associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.7   0.7         7   1.8e+04      86      96 ..       4      14 ..       3      16 .. 0.47
   2 ?   -1.5   0.0      0.97   2.5e+03       9      26 ..      45      62 ..      37      77 .. 0.56
   3 ?   -1.1   0.2      0.74   1.9e+03      92     106 ..     138     152 ..     132     160 .. 0.63
   4 ?    0.4   3.9      0.24   6.1e+02       7      66 ..     156     210 ..     150     222 .. 0.86
   5 ?   11.0   0.1   0.00013      0.33      82     122 ..     279     319 ..     255     341 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.7 bits;  conditional E-value: 7
  COPI_assoc 86 vlsilialllf 96
                +++i+i+ll++
  EFC35910.1  4 IFQIMISLLVL 14
                34555555544 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.97
  COPI_assoc  9 lvvgglaillgisqliil 26
                ++ +  +illg+  +i +
  EFC35910.1 45 IILFIGTILLGVCIFIRI 62
                333344444444444444 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.74
  COPI_assoc  92 alllflvGLvyillh 106
                 ++l f++GL +++  
  EFC35910.1 138 GILSFILGLGCLIAF 152
                 566777777765543 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.24
  COPI_assoc   7 lnlvvgglaillgisqliilfsnflsfilsiYiillgivlillEfrvpfeiykyfsfmfs 66 
                 ++++++++  ++ i++ ++ + n ++++ s Yi + ++     E+   +++++++ + ++
  EFC35910.1 156 MSIGFSVVNNVMYITSNVSNIPNSFQLYYSNYIYACCL-----EVYNSYYALDQATYITT 210
                 78999999999999999999************999998.....88777777777776655 PP

  == domain 5  score: 11.0 bits;  conditional E-value: 0.00013
  COPI_assoc  82 syggvlsilialllflvGLvyillhlvpsieepenlkkena 122
                   +g   i ++ll+f++G+v+++++   s++ p+   ++++
  EFC35910.1 279 VATGSCGISLGLLFFIFGIVCFFMGRNLSQDLPQYTSNNTI 319
                 456788999*****************888888887766655 PP

>> DUF2721  Protein of unknown function (DUF2721)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.4       1.2   3.2e+03      70      82 ..      41      53 ..       5      64 .. 0.63
   2 ?   -0.1   0.1      0.32   8.2e+02      98     114 ..     138     154 ..     128     166 .. 0.79
   3 ?   10.6   0.0   0.00016       0.4      25     112 ..     218     303 ..     205     307 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.2
     DUF2721 70 lvlsallvvlvvl 82
                ++ s++l++ ++l
  EFC35910.1 41 ITPSIILFIGTIL 53
                2333333333333 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.32
     DUF2721  98 aailfvlalllllvsll 114
                   + f+l+l +l++ l+
  EFC35910.1 138 GILSFILGLGCLIAFLI 154
                 56789999999987665 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00016
     DUF2721  25 iadrirqLedeleelaeeeeedeelakeiknlrrRarlirrailllvlsallvvlvvlllflsallsldlsllaailfvlalllllvs 112
                 +++ i++L   + ++++++++ + + + i+++r Ra+ i +a +++ ++a+++v  +l  ++  ++     +l  ++f++++++++++
  EFC35910.1 218 LVKGINSLYCAIPQQNTNTHNGTIYGNFIDQVRGRAQAIEYAKTSCNAGAVIFVPDILETVV--ATGSCGISLGLLFFIFGIVCFFMG 303
                 66667777777777777777655566669*********************************..677788889999999999999876 PP

>> DUF3139  Protein of unknown function (DUF3139)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.4       4.1   1.1e+04       5      16 ..       5      16 ..       1      20 [. 0.52
   2 ?    2.5   0.0     0.092   2.3e+02       6      36 ..      45      74 ..      42     101 .. 0.71
   3 ?    0.9   0.3      0.28   7.3e+02      37      69 ..     161     189 ..     136     196 .. 0.56
   4 ?    7.7   0.0    0.0022       5.7       6      50 ..     286     339 ..     283     364 .] 0.67

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 4.1
     DUF3139  5 iiililliillv 16
                  i+i+l++llv
  EFC35910.1  5 FQIMISLLVLLV 16
                334555555443 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.092
     DUF3139  6 iililliillvivkvflglvgskpikkylan 36
                iil++  ill  v++f+ +   ++i++y++ 
  EFC35910.1 45 IILFIGTILLG-VCIFIRIYQRNEINSYYQD 74
                45554444444.4788867777777777764 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.28
     DUF3139  37 kkldkylqekgykeddIksikpkydskkgsyya 69 
                   +++ +    y  +++++i  +++ + ++y +
  EFC35910.1 161 SVVNNVM----YITSNVSNIPNSFQLYYSNYIY 189
                 3345555....6667777777777777776655 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.0022
     DUF3139   6 iililliillvivkvflglvgskpikkylan...kkldkyl......qekgyke 50 
                 i l+ll+ +  iv++f+g + s+ + +y++n     +++ +      q ++ +e
  EFC35910.1 286 ISLGLLFFIFGIVCFFMGRNLSQDLPQYTSNntiPVISSVMmnelpeQNQNSTE 339
                 77889999999999999*************944444566666666554444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (364 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       852  (0.0475208); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.41u 0.28s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 2595.69
//
Query:       EFC35911.1  [L=258]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-15   57.8   8.7    1.5e-15   57.8   8.7    3.0  2  NST1           Salt tolerance down-regulator
  ------ inclusion threshold ------
        1.5    9.2  11.5        0.1   12.8   3.1    2.9  3  Syntaxin-18_N  SNARE-complex protein Syntaxin-18 N-terminus


Domain annotation for each model (and alignments):
>> NST1  Salt tolerance down-regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.8   8.7   1.7e-19   1.5e-15      73     180 ..       7     114 ..       1     127 [. 0.78
   2 ?   -6.6  12.5         2   1.8e+04      65     108 ..     155     199 ..     118     252 .. 0.46

  Alignments for each domain:
  == domain 1  score: 57.8 bits;  conditional E-value: 1.7e-19
        NST1  73 svknnppsvssaalrsakkvskdrsiwntssqE..ereklkeFWlsLgEeERReLvkvEKeavLkKmKeqqKhsCsCsvCGRkRvaiEEELEvlYDaYY 169
                 s+ ++++s+s+++++s+k ++ + ++ ++s++   +   l +FW  L    R++L +v+  ++LkK Keq +  CsC+vCGR + +++ EL+ l+  Y 
  EFC35911.1   7 SN-SKKKSTSKSQSKSEKSSAPQPQTVKRSTTLesQITTLNDFWRTLNFGTRKKLLHVDACSLLKKTKEQYQRVCSCTVCGRNKSILDRELDRLFTDYC 104
                 22.234444445555655556666678888775145568************************************************************ PP

        NST1 170 eeLeqYanmnd 180
                  eL  Y+n+ d
  EFC35911.1 105 KELA-YQNHVD 114
                 **97.556555 PP

  == domain 2  score: -6.6 bits;  conditional E-value: 2
        NST1  65 aittssarsvknnppsvssaalrsakkvskdrsiwntssqE.ere 108
                 ++t++++  v+  +++v+  ++ + + + k +s + ++ +E +re
  EFC35911.1 155 TTTVKKSGNVRVIEKTVKYYSTTKVNPNDKASSPIIEDITEdNRE 199
                 222222222333333333222222222222222222222221232 PP

>> Syntaxin-18_N  SNARE-complex protein Syntaxin-18 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   3.1   1.2e-05       0.1      18      61 ..       5      48 ..       2      53 .. 0.85
   2 ?    0.3   0.0     0.095   8.5e+02      22      42 ..     123     143 ..      98     157 .. 0.53
   3 ?   -0.7   0.2       0.2   1.8e+03      14      14 ..     204     204 ..     168     239 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.2e-05
  Syntaxin-18_N 18 ssskseekeakkrkkkrlkkskekdeFikeAkeilkhItkLrkf 61
                   +ss s++k+++k+++k++k+s+++ + +k++ ++ ++It+L++f
     EFC35911.1  5 KSSNSKKKSTSKSQSKSEKSSAPQPQTVKRSTTLESQITTLNDF 48
                   4566777778888999999999999*****************99 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.095
  Syntaxin-18_N  22 seekeakkrkkkrlkkskekd 42 
                    s++++++k ++++++ +++k 
     EFC35911.1 123 SNSSDRSKLRNNSRSPKTTKR 143
                    222333333333333333333 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.2
  Syntaxin-18_N  14 v 14 
                    +
     EFC35911.1 204 K 204
                    1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2162  (0.120587); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 1622.88
//
Query:       EFC35912.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.3e-22   79.7  25.9    2.6e-22   79.5  25.9    1.0  1  TPT           Triose-phosphate Transporter family
    4.5e-08   33.3  30.5    1.6e-06   28.4  15.4    2.9  2  EamA          EamA-like transporter family
    0.00029   20.1  31.0    0.00044   19.5  31.0    1.4  1  UAA           UAA transporter family
  ------ inclusion threshold ------
      0.018   15.2   0.4       0.12   12.6   0.2    2.1  2  Ly-6_related  Caenorhabditis elegans ly-6-related protein
        1.3    8.4   6.8        1.9    8.0   5.8    1.8  1  DUF1129       Protein of unknown function (DUF1129)
        7.7    5.6  26.8         26    3.9  26.8    2.3  1  PUNUT         Purine nucleobase transmembrane transport


Domain annotation for each model (and alignments):
>> TPT  Triose-phosphate Transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5  25.9   8.7e-26   2.6e-22      13     290 .]       9     303 ..       1     303 [. 0.88

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 8.7e-26
         TPT  13 lnvvfnilnKkilnvf....pyPltvsavqllvgsvlilvlwal.glkk...........rpkisse..flkailplalvktlghvlavvslskvaVSf 93 
                 ++++  +l K+++ +     ++Plt++ ++l+v  ++i+++++l +lkk            p+++ +  + ++i p++l+ +    + ++ l    +  
  EFC35912.1   9 TSILSVFLTKYLMDMGeysfHFPLTMAWFHLIVSLLCIICTYNLnRLKKtnhlirtcfsfLPDFEFKfdTAVQIAPVSLCYVGMVTFNNLCLDYADIHT 107
                 566666777777775333339**********************977888***********666666655999*************************** PP

         TPT  94 thtvKasePiFtvilsrlllgeklsllvylsLlpivgGvalasvtElsF...nligfisAlisnltfslrnifsKkllkklkdldalnlfaiitilsll 189
                  ht +++   Ftvi++++llgek++  ++ + l i  G  ++ + El+    + igf   l+s  + +l +i+ Kkl++++ + ++  ++ +  ++++l
  EFC35912.1 108 YHTARSISICFTVIFTSVLLGEKVQKRIIGACLMIAIGYFMTGFEELQLskmQSIGFAFGLMSSCFMALYSIYLKKLMSSS-HRNHWIILIYNVVCAIL 205
                 ***********************************************86222679*************************3.46777788888889999 PP

         TPT 190 lllPvallvegvlktpsllkstkvslkevllllllsgvlfhlynqvaymvLervspvthsvantvKrvvvIvlsvlvfknpvsllnaiGtavaivGvfl 288
                 +l+Pv  ++ ++ k +s+         ++l+ l + +++ ++ n+  +m+++ +sp+t sv  ++K vv   ls  v +++vs+  ++ +a ++vG++l
  EFC35912.1 206 FLFPVCYFTGEFEKAISVNYL---FEPKFLAILTTTALIAYVVNISNFMLISYTSPLTTSVTISMKSVVESFLSFAVHNTHVSTYGLLSSAFTVVGTYL 301
                 999*99888875444444333...3799*********************************************************************** PP

         TPT 289 Ys 290
                 Ys
  EFC35912.1 302 YS 303
                 *8 PP

>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   7.1   0.00034         1      82     135 ..      96     149 ..       2     151 .. 0.83
   2 !   28.4  15.4   5.2e-10   1.6e-06       2     136 ..     162     303 ..     161     304 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00034
        EamA  82 ffyalkktsasnaslitslePvftlilsvlllgekltlkqllgivlillGvlli 135
                  +  l + +  +   + s++  ft+i+ ++llgek++++ + ++++i +G +++
  EFC35912.1  96 NNLCLDYADIHTYHTARSISICFTVIFTSVLLGEKVQKRIIGACLMIAIGYFMT 149
                 455666666677777789999*****************************9987 PP

  == domain 2  score: 28.4 bits;  conditional E-value: 5.2e-10
        EamA   2 lgillallaalfwaiyfvlskillrkv..spltltfvrfliagillliiallkegklaklslkd.....wllllllgllgtvlafllffyalkktsasn 93 
                 +g  + l +++f+a+y ++ k+l+++   + + ++ +  + a ++l++++ ++++  + +s++      +l++l + +l   ++++  f+++++ts+ +
  EFC35912.1 162 IGFAFGLMSSCFMALYSIYLKKLMSSShrNHWIILIYNVVCAILFLFPVCYFTGEFEKAISVNYlfepkFLAILTTTALIAYVVNISNFMLISYTSPLT 260
                 678899**************9997766457889999******************99977777765566666666666667777789************* PP

        EamA  94 aslitslePvftlilsvlllgekltlkqllgivlillGvllil 136
                  s+ +s+  v+  +ls+++ + +++ + ll+ ++ ++G++l +
  EFC35912.1 261 TSVTISMKSVVESFLSFAVHNTHVSTYGLLSSAFTVVGTYLYS 303
                 ***************************************9976 PP

>> UAA  UAA transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5  31.0   1.5e-07   0.00044      69     301 ..      86     305 ..       1     306 [. 0.82

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.5e-07
         UAA  69 valffitsvlnnealkydisvPvhiifrssklipvmilGililgkrYsllqylsvllltlGviiftllsakdkkedskeslnkfllGiallvlalllda 167
                 ++  +++ + nn  l+y   + +   +rs ++  + i   ++lg + +++ + + l++++G ++  +       e+ + s++ +++G+a  +++ +++a
  EFC35912.1  86 SLCYVGMVTFNNLCLDY-ADIHTYHTARSISICFTVIFTSVLLGEKVQKRIIGACLMIAIGYFMTGF-------EELQLSKM-QSIGFAFGLMSSCFMA 175
                 5667788889*******.89999999*****************************************.......44344443.689************* PP

         UAA 168 vlglvqeklykkygkhskealfyshllslplfl...llqgellsavkflsesedvallslpsklfylllnvltqyvcikgVlilisefgaltvtlvltl 263
                 + +++  kl++    +   +l y+ ++++++++    ++ge+ +a+ +    e++        l  l   +l++yv   + ++lis ++ lt+++ +++
  EFC35912.1 176 LYSIYLKKLMSSSHRNHWIILIYNVVCAILFLFpvcYFTGEFEKAISVNYLFEPKF-------LAILTTTALIAYVVNISNFMLISYTSPLTTSVTISM 267
                 **********9655444455555555555555566666666666666666655555.......69999999*****999******************** PP

         UAA 264 RKfvslllSillFknpltlqhlvgtllVflglllysyv 301
                   +v   lS+ + + +++   l+++++ ++g++lysy 
  EFC35912.1 268 KSVVESFLSFAVHNTHVSTYGLLSSAFTVVGTYLYSYF 305
                 ***********************************996 PP

>> Ly-6_related  Caenorhabditis elegans ly-6-related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.25   7.4e+02      55      89 ..      53      86 ..      42      92 .. 0.66
   2 ?   12.6   0.2   4.1e-05      0.12      17      69 ..      89     141 ..      80     163 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.25
  Ly-6_related 55 agvkigkkviRGClssvlrkglnakktlsllerkd 89
                  +  k+ ++ iR C+s +  + ++   t+ +++  +
    EFC35912.1 53 NRLKKTNHLIRTCFSFLPDFEFK-FDTAVQIAPVS 86
                  455667789*****998888777.33333355555 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 4.1e-05
  Ly-6_related  17 ykePknFtdrCdeeeaeskielvaCssiCvtlvedkvvagvkigkkviRGCls 69 
                   y    +F++ C + ++ ++ ++ +  siC+t++  +v+ g+k++k++i  Cl 
    EFC35912.1  89 YVGMVTFNNLCLDYADIHTYHTARSISICFTVIFTSVLLGEKVQKRIIGACLM 141
                   5555689********999******************************99985 PP

>> DUF1129  Protein of unknown function (DUF1129)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   5.8   0.00062       1.9      89     195 ..     142     244 ..     129     255 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00062
     DUF1129  89 lalfallfgilalfskkkqtasiGlitlllvalvgGlamvlvyrlltrekkkkkrpplwkrllilllllvvwlvlftlvallpavi..NpvLpplvlii 185
                 +a+  +++g+  l  + k+++ iG    + ++l++ ++m l+  +l++ +++++r+ ++  +  ++ ++++++ ++++++ + + i  N   +p  l+i
  EFC35912.1 142 IAIGYFMTGFEELQLS-KMQS-IG----FAFGLMSSCFMALYSIYLKKLMSSSHRNHWIILIYNVVCAILFLFPVCYFTGEFEKAIsvNYLFEPKFLAI 234
                 4444444444442222.2222.23....56788888889999999988899***********9999999999999888888776552277788888888 PP

     DUF1129 186 igviafvvry 195
                 +   a+++++
  EFC35912.1 235 LTTTALIAYV 244
                 7777666654 PP

>> PUNUT  Purine nucleobase transmembrane transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9  26.8    0.0088        26      72     321 ..      78     311 ..       1     312 [. 0.70

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.0088
       PUNUT  72 kklvllyivlGllvavdnllyslgllylpvstfslilatqLaFtaifsalinkqkftrfiinsvvlltisaallalssssdkpaeeskkkyvigfiltl 170
                 + + ++ ++l+  +    ++  l l y  + t+    + ++ Ft if+ ++   k+   ii + +++ i+  +++ ++   + ++ +    +igf+  l
  EFC35912.1  78 TAVQIAPVSLC--YVGMVTFNNLCLDYADIHTYHTARSISICFTVIFTSVLLGEKVQKRIIGACLMIAIGYFMTGFEEL--QLSKMQ----SIGFAFGL 168
                 22333333333..33344566677888999999999999**************************99999999995543..344444....79**9999 PP

       PUNUT 171 aasllfaLlLslvellfekvlkketfslvlemqivlslvatvvcvvGllisGefkelkkeaeeFkkGkslYvlvlvgsavswQvlavGavgLvflvSsl 269
                 ++s ++aL+   +++l+++  +    ++++ +  v++ + +++ v      Gef++  +    F   +  + ++l  +a++  v+ +    L+ ++S l
  EFC35912.1 169 MSSCFMALYSIYLKKLMSSSHR---NHWIILIYNVVCAILFLFPV--CYFTGEFEKAISVNYLF---EPKFLAILTTTALIAYVVNISNFMLISYTSPL 259
                 9999998875555555554443...56666666666666666555..4679**98766655566...689***************************** PP

       PUNUT 270 fsnvistvllpvvsvlavilfrdkfsavkgvalllailgfasYvYgeykskk 321
                 +  v++++ + v s l  ++ + ++s    ++ + +++g   Y Y ++k+k+
  EFC35912.1 260 TTSVTISMKSVVESFLSFAVHNTHVSTYGLLSSAFTVVGTYLYSYFKVKDKR 311
                 ***********************************************99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1087  (0.060628); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 1841.19
//
Query:       EFC35913.1  [L=239]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.7e-14   52.1   2.6     0.0028   17.5   0.1    5.1  5  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0   8.7e-05       1.6       5      29 ..      22      46 ..      19      57 .. 0.87
   2 !    4.2   0.1    0.0023        41      64      90 ..      65      93 ..      60      97 .. 0.71
   3 !   10.4   0.0   2.6e-05      0.47       5      29 ..     111     135 ..     109     143 .. 0.89
   4 !   17.5   0.1   1.6e-07    0.0028      61      92 ..     150     181 ..     144     186 .. 0.90
   5 !    6.9   0.0   0.00032       5.7       6      41 ..     194     229 ..     190     237 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 8.7e-05
                HHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr  5 vlkellaGglagavatlvttPldvv 29
                +l + l+Gg++ a++ ++t+P+d+ 
  EFC35913.1 22 FLTDYLIGGASRAIGRTLTAPIDRF 46
                567899*****************75 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0023
                GGTTHHHHHHHHHHHHHH..HHHHHHHHH CS
   Mito_carr 64 lyrGllpnllrvapasal..kfvlyetlk 90
                ++rG+l n+++++  + +  +f++ + +k
  EFC35913.1 65 FWRGNLLNMIKSFFPNTVvfNFAIKDLIK 93
                9**********987665511455555555 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 2.6e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvv 29 
                 v++++++Gglaga+  +v +P+d +
  EFC35913.1 111 VVNQFVSGGLAGACCEFVRFPFDNI 135
                 6899******************954 PP

  == domain 4  score: 17.5 bits;  conditional E-value: 1.6e-07
                 HHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr  61 lrglyrGllpnllrvapasalkfvlyetlkrl 92 
                   gl++G++++++  +++++l+f+l+++l+++
  EFC35913.1 150 YFGLFKGAGISVMSAMVYRSLYFGLNDSLREV 181
                 679*************************9986 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.00032
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSST CS
   Mito_carr   6 lkellaGglagavatlvttPldvvKtrlqtqkkssk 41 
                 +++  ++ la a a+++  P+ ++  r+ +q++ s 
  EFC35913.1 194 ISKYGIAQLASASAWIMNSPISTIQRRMIMQQQYSP 229
                 566667889*********************998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       307  (0.0171231); expected 358.6 (0.02)
Passed bias filter:                      252  (0.0140554); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 1432.03
//
Query:       EFC35914.1  [L=391]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-11   44.6   0.1    4.1e-11   43.2   0.1    1.7  1  RNase_H   RNase H


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.2   0.1   2.3e-15   4.1e-11       5     141 ..      69     193 ..      65     195 .. 0.76

  Alignments for each domain:
  == domain 1  score: 43.2 bits;  conditional E-value: 2.3e-15
                 EEEEEEEEECTTTCEEEEE.EE.CTT......EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSB CS
     RNase_H   5 vvYtDGsclgnpgeggaga.vl.ykeg....arnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkp 97 
                  ++tDGs l  +++ g+g+ ++  + +     r +s +++++ +nn aE++ +i+a k   +d+k++i tDS+ +++ +++         ++ + ++ p
  EFC35914.1  69 DIHTDGSRL--ESKTGMGInIYdCS-NmntpVRSLSLHINDQYSNNVAEICSIITAAKVIPRDSKIKIHTDSNVAIE-VLK---------ERYKGNFLP 154
                 589****66..67777888444222.2443444777777799****************989***********99999.555.........223445556 PP

                 HTTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHH CS
     RNase_H  98 vknkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkea 141
                 +k+   ++++    +k + ++k+v++H+    +N  +D lAk+a
  EFC35914.1 155 LKK-AFFKTI--KDRKLEYEFKKVEAHKDK--ENIKVDLLAKNA 193
                 777.555555..2558899*********98..8*********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       905  (0.0504769); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 2458.34
//
Query:       EFC35915.1  [L=842]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (842 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1186  (0.0661498); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.76u 0.30s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 4691.41
//
Query:       EFC35916.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       739  (0.0412181); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1563.11
//
Query:       EFC35917.1  [L=186]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.079   12.5   0.0       0.14   11.7   0.0    1.5  1  YhfZ_C    YhfZ C-terminal domain


Domain annotation for each model (and alignments):
>> YhfZ_C  YhfZ C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   7.6e-06      0.14      10      71 ..      73     132 ..      64     144 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7.6e-06
      YhfZ_C  10 glrnlvgamPlpyskkyeGLatglkaafeklgiplnlaymrGadkRlealkegrydfavvSr 71 
                 + +nl+ +  +p s k++ L t l++ f+++ i   + +++G  +R+  l+   +d++++Sr
  EFC35917.1  73 KQHNLLDIAFIPASLKMSTLWTKLNSDFNQKRIVNFYGFVKGYGQRFHILE--DFDMIITSR 132
                 5566666666899*******************99999************97..59******8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       705  (0.0393218); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.52
# Mc/sec: 1084.53
//
Query:       EFC35918.1  [L=146]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0052   17.1   2.4      0.007   16.7   2.4    1.1  1  DUF4680   Domain of unknown function (DUF4680)
  ------ inclusion threshold ------
       0.14   12.0   4.0      0.081   12.7   1.7    1.7  2  Nop52     Nucleolar protein,Nop52
       0.24   10.0   5.4       0.27    9.9   5.4    1.0  1  Ndc1_Nup  Nucleoporin protein Ndc1-Nup
       0.72    9.6   7.9       0.89    9.3   7.7    1.3  1  ATP11     ATP11 protein


Domain annotation for each model (and alignments):
>> DUF4680  Domain of unknown function (DUF4680)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   2.4   1.6e-06     0.007      52     120 ..      13      84 ..       2      95 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.6e-06
     DUF4680  52 paaPdsassqrassarsatrqaaragliqknlakkfdfpi..pLnea.sklmkkkkkvsvWnrvykvisrml 120
                  ++P sas q  s  +s++++  + g  qk+++kk    i  +L ++ +  +++ +   vW+  +kv s+ +
  EFC35918.1  13 YTSPRSASDQEESDQESTQNKQTSQGTPQKKVSKKRTKRIipNLSDTkFASLNHTRLKKVWQTKHKVFSKGI 84 
                 4689***************************99998766633354441233334444579********9854 PP

>> Nop52  Nucleolar protein,Nop52
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.1     0.092   4.1e+02      11      44 ..      41      74 ..      36      76 .. 0.83
   2 ?   12.7   1.7   1.8e-05     0.081     104     180 ..      60     140 ..      56     145 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.092
       Nop52 11 dkktRdkalksLrkfLskkkkkklselellkLwk 44
                +kk+ +k  k++   Ls+ k ++l+++ l+k+w+
  EFC35918.1 41 QKKVSKKRTKRIIPNLSDTKFASLNHTRLKKVWQ 74
                5677778888888889999988899*******97 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 1.8e-05
       Nop52 104 KfllLvRrvlreslkllkkeewdkelveeylevlket....plss.edkkvpnglayhladiyldelekvleseleeeeeee 180
                 Kf  L  + l++  +  k++ ++k +++ + ++++++    +l++ +++++  +la+h+++++ + le  +e+el+e+eee+
  EFC35918.1  60 KFASLNHTRLKKVWQ-TKHKVFSKGIIQGFYKYVQKQgsdfVLDIlKKEELLVSLAHHFVKLFSETLEARSEEELTEREEED 140
                 666666666766666.456678999999999988888788855441455578********************9999998885 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   5.4     6e-05      0.27     370     494 ..       8     131 ..       1     141 [. 0.47

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 6e-05
    Ndc1_Nup 370 asapvkelprlsksplkkkddeifgnsltaeaspkssssskegvekalsslakspgqspsptarls.prarkllekaksrlls.......keqkealse 460
                 +++++ ++pr++++ + + d+e  +n++t++ +p+++  sk+++++ + +l+ +  +s      l+  r +k+++++ + + +       k        
  EFC35918.1   8 TPSNQYTSPRSASDQEES-DQESTQNKQTSQGTPQKK-VSKKRTKRIIPNLSDTKFAS------LNhTRLKKVWQTKHKVFSKgiiqgfyK-------- 90 
                 222333344443222222.333333333333333333.33333333333333333322......223677788877777666633333332........ PP

    Ndc1_Nup 461 stikkkvekelaqllksp........ligylFrqslrrrlea 494
                   ++k+ +++++++lk++         ++ lF+++l++r+e 
  EFC35918.1  91 -YVQKQGSDFVLDILKKEellvslahHFVKLFSETLEARSEE 131
                 .222222333333333225777777789*********99875 PP

>> ATP11  ATP11 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   7.7    0.0002      0.89      48     114 ..      13      78 ..       2     108 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0002
                 XXXXXXXXXXXXXXXXXXXXXXXXXX---.......SS--HHHHS-HHHHTTS-HHHHHHHHHHHTT CS
       ATP11  48 sksesekekeakasssektekkesaakskkkskskspvkpLssildleklkelpakeiealWrarha 114
                 + ++ ++++ +++s +e+t++k++++ + +k+ sk+  k     l   k ++l+++ ++++W+++h+
  EFC35918.1  13 Y-TSPRSASDQEESDQESTQNKQTSQGTPQKKVSKKRTKRIIPNLSDTKFASLNHTRLKKVWQTKHK 78 
                 2.2222223333333333333333344447788888888888888889******************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1944  (0.108428); expected 358.6 (0.02)
Passed bias filter:                      649  (0.0361983); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 857.90
//
Query:       EFC35919.1  [L=770]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.049   13.8   0.7         11    6.2   0.1    3.0  3  Ribonuc_2-5A    Ribonuclease 2-5A
       0.18   11.8   0.1       0.45   10.5   0.1    1.6  1  Arm_vescicular  Armadillo tether-repeat of vescicular transpo
       0.66   10.4   4.0       0.41   11.1   0.1    2.5  3  CelTOS          Cell-traversal protein for ookinetes and spor
        1.5    9.7   4.4        1.7    9.5   0.0    3.2  4  Csm2_III-A      Csm2 Type III-A
        9.1    6.3   6.8          3    7.9   0.2    3.4  5  Symplekin_C     Symplekin tight junction protein C terminal


Domain annotation for each model (and alignments):
>> Ribonuc_2-5A  Ribonuclease 2-5A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.1    0.0031        11       2      55 ..      72     126 ..      71     134 .. 0.85
   2 ?    4.7   0.0    0.0091        33      89     113 ..     243     267 ..     234     275 .. 0.84
   3 ?   -3.4   0.0       2.9   1.1e+04      55      69 ..     393     408 ..     371     430 .. 0.57

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0031
  Ribonuc_2-5A   2 lefLrdvSdrfeiekrdpesellkkLeseasevvks.dWtkkldkelvdslgkyr 55 
                    +f  d+  + e  ++ +++ell++L++ +++v+++ +++k+  k+lv++l + +
    EFC35919.1  72 TKFVLDINQKAEAWPTYTSEELLQHLKEMRNRVINQaSYRKEPCKTLVQNLIEMY 126
                   67899999999999*999999******9999996666*************96554 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0091
  Ribonuc_2-5A  89 elpegflsYftkrFPkLlievyevv 113
                    +p+  ++Yf k F +L+++ y++ 
    EFC35919.1 243 GVPSLQVKYFLKHFKSLIVTYYNAS 267
                   5788889*************99875 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 2.9
  Ribonuc_2-5A  55 rkYkg.dsvrdLLRai 69 
                    kY+  + v d LRa+
    EFC35919.1 393 LKYSDeELVIDCLRAL 408
                   2554304456777776 PP

>> Arm_vescicular  Armadillo tether-repeat of vescicular transport factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.1   0.00012      0.45      13      41 ..     399     427 ..     394     433 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00012
  Arm_vescicular  13 hlmLqvvRaLVspsnpsqvvrsCqkamrk 41 
                     +l+++ +RaL spsn++ + + C++++++
      EFC35919.1 399 ELVIDCLRALSSPSNNQRNFSRCKNVVQA 427
                     5678889******************9975 PP

>> CelTOS  Cell-traversal protein for ookinetes and sporozoites
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1      0.62   2.2e+03      16      46 ..     362     395 ..     350     434 .. 0.72
   2 ?   11.1   0.1   0.00012      0.41      10      59 ..     538     586 ..     533     606 .. 0.81
   3 ?   -3.2   0.1       3.1   1.1e+04      44      46 ..     704     706 ..     684     726 .. 0.41

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.62
      CelTOS  16 klseiir..adldskgd.elvdliandlekelqk 46 
                 ++++ii+  + +d+ gd ++v+ i++ l + l+ 
  EFC35919.1 362 RVRKIISimEIIDQRGDnNIVESISSFLTRLLKY 395
                 5555554226678887635889998888887764 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00012
      CelTOS  10 qkslssklseiiradldskgdelvdliandlekelqknslvaasfLqsgf 59 
                  ++l+  l ei+r  +dsk  e+vd++ + l+++l + +l++++f + g+
  EFC35919.1 538 SETLVRPLDEIVRGAIDSKSLEVVDIVQK-LVESLLNTELTKLVFKNLGN 586
                 567888999****************7665.66666777789999977664 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 3.1
      CelTOS  44 lqk 46 
                 l  
  EFC35919.1 704 LYV 706
                 222 PP

>> Csm2_III-A  Csm2 Type III-A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00047       1.7      36      92 ..      76     133 ..      73     146 .. 0.87
   2 ?   -1.2   0.0      0.99   3.6e+03      21      73 ..     242     295 ..     235     337 .. 0.64
   3 ?   -1.5   0.1       1.2   4.3e+03      85      85 ..     393     393 ..     315     429 .. 0.55
   4 ?   -2.1   0.2       1.9   6.7e+03      56     105 ..     476     524 ..     459     528 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00047
                 HHHHHHHHHTHHHHHHHTHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHH--SH. CS
  Csm2_III-A  36 krieekikkkkeeeseeilrklkllkpklaYaag.reeavkelsevlkkaidkvkksk 92 
                  +i++k + + + +see+l++lk ++ +++++a+ r+e  k+l++ l ++ ++v++ k
  EFC35919.1  76 LDINQKAEAWPTYTSEELLQHLKEMRNRVINQASyRKEPCKTLVQNLIEMYKTVSNGK 133
                 567788888888889***************9987478****************99974 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.99
                 TTS-STTTHHHHHHHHHHHHHHHHTHHHH.HHHTHHHHHHHHHHHHHHHHHHHH CS
  Csm2_III-A  21 kklktsqiRkfydevkrieekikkkkeee.seeilrklkllkpklaYaagreea 73 
                   + + q+  f++++k++   + + ++ e s   ++++  +   l+Y+++ e +
  EFC35919.1 242 AGVPSLQVKYFLKHFKSLIVTYYNASNWEgSYIDMNDMDCILLDLIYKSKDEDQ 295
                 456777888888888888888777777776666677777777888887776433 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1.2
                 H CS
  Csm2_III-A  85 i 85 
                 +
  EFC35919.1 393 L 393
                 1 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 1.9
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--SH.HHHHHHHHHHHHH CS
  Csm2_III-A  56 klkllkpklaYaagreeavkelsevlkkaidkvkkskekfkrfvdffEAi 105
                 k+++lk+  a  + +      +se+  ++i+kv +  ++ + f+++ ++i
  EFC35919.1 476 KVNYLKIFTAAFKYC-CTESIFSEKALEVIQKVAECMKEQDYFLQVADSI 524
                 566666544433333.1223366666666666665555555555555544 PP

>> Symplekin_C  Symplekin tight junction protein C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       2.8     1e+04      51      69 ..      83     101 ..      72     123 .. 0.63
   2 ?   -1.0   0.0      0.44   1.6e+03      17      48 ..     385     417 ..     367     444 .. 0.67
   3 ?    7.9   0.2   0.00085         3      79     127 ..     502     548 ..     488     569 .. 0.89
   4 ?   -1.8   0.0      0.79   2.8e+03      16      44 ..     559     589 ..     553     606 .. 0.76
   5 ?   -1.5   0.1      0.64   2.3e+03      59     106 ..     667     717 ..     653     723 .. 0.65

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.8
  Symplekin_C  51 kekspltpaellvalhnle 69 
                  ++  ++t++ell +l ++ 
   EFC35919.1  83 EAWPTYTSEELLQHLKEMR 101
                  4455677777777777666 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.44
  Symplekin_C  17 vislLpklikl.nekvvkevfrrllaassekse 48 
                  + s+L +l+k  +e++v +++r l ++s+++++
   EFC35919.1 385 ISSFLTRLLKYsDEELVIDCLRALSSPSNNQRN 417
                  445556666657788888888888887773322 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.00085
  Symplekin_C  79 slvealdlclsekevftqevlaaalqqlveeeplpllfmrtviqalkky 127
                  ++++++  c++e+++f q  +a+ +q l++ ++lp +f +t+++ l+++
   EFC35919.1 502 EVIQKVAECMKEQDYFLQ--VADSIQALLNIPALPSVFSETLVRPLDEI 548
                  6899************87..89********************9877765 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 0.79
  Symplekin_C  16 evislLpklikl..nekvvkevfrrllaass 44 
                  ev+++ +kl+++  n ++ k vf++l  + +
   EFC35919.1 559 EVVDIVQKLVESllNTELTKLVFKNLGNIVH 589
                  7888899999988889999999988876665 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 0.64
  Symplekin_C  59 aellvalhnlekkkkevelkslvealdlclseke...vftqevlaaalqql 106
                  a++ +  hnl+  +k  +++ + +a+  c+s +e   ++    l  + qql
   EFC35919.1 667 AHITLGQHNLDVRPKHLNVDDIFDAITDCISFNEsrsLYVTSLLKRITQQL 717
                  556666788888888999999999999998533322255444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (770 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       931  (0.051927); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 4386.03
//
Query:       EFC35920.1  [L=605]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.7e-39  134.7   0.8      7e-39  133.8   0.2    1.8  2  Pkinase      Protein kinase domain
    6.5e-26   91.2   0.0    9.4e-26   90.6   0.0    1.2  1  Pkinase_Tyr  Protein tyrosine kinase
    4.5e-11   43.2   0.0      9e-11   42.2   0.0    1.5  1  Cyclase      Putative cyclase
     0.0062   15.9   0.0      0.011   15.1   0.0    1.3  1  Kdo          Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.8   0.2   1.6e-42     7e-39       1     182 [.     128     324 ..     128     386 .. 0.84
   2 ?   -3.5   0.0       1.2   5.2e+03     181     211 ..     539     569 ..     538     591 .. 0.67

  Alignments for each domain:
  == domain 1  score: 133.8 bits;  conditional E-value: 1.6e-42
                 EEEEEEEEEESSEEEEEEE..ETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHSCTTB--EEEEEEE....SSEEEEEEE--TTEBHHHHHH.. CS
     Pkinase   1 yekleklGeGsfGkVykav..eketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfee....kdelylvleyveggeladlle.. 90 
                 y+ ++ +GeG+fG ++++   ++ ++  vA+K+i++ k++ +k  +++ +E +++k+l+h+n+v++y++f+     ++ +++v+e+ +g+ ++++++  
  EFC35920.1 128 YKIIRIIGEGGFGIIFECQvlNTPEEPNVAIKTIATGKNSIQKPtQDAENEANLVKQLDHQNVVKIYDTFQVdtehSSMFCIVMELYKGD-VMSIISes 225
                 78899**********9986115666778********99999888899***********************98777666778*******77.66666645 PP

                 ..HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE......EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHH CS
     Pkinase  91 ..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge......lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDv 180
                      +++   + ki++q+ ++l+y+Hs++++HrD+Kp+Ni+i  ++        + ++DFG+ake  +++ ++++ g+  Y++PE+l +++y+ ++D+
  EFC35920.1 226 ikSAATIPLPIIWKIISQTTQALNYVHSQQVMHRDIKPQNIFIRrRD-IdsnlieVVLGDFGIAKENAHTT-KNTYAGSLCYISPELLLNQPYGFATDI 322
                 53556688889*********************************433.35889999**********99988.9*************************9 PP

                 HH CS
     Pkinase 181 Ws 182
                  s
  EFC35920.1 323 LS 324
                 87 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHHSS-STTTSSHHHHHHHHHH CS
     Pkinase 181 WslGvilyelltgkppfsgekgkekvekeld 211
                 W + + ++e l+ +++fs+++++++++ + +
  EFC35920.1 539 WNARIAILENLNCEMIFSHTTNSSDNSINSN 569
                 6666778888888999997666665544443 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.6   0.0   2.1e-29   9.4e-26       3     210 ..     130     343 ..     128     388 .. 0.82

  Alignments for each domain:
  == domain 1  score: 90.6 bits;  conditional E-value: 2.1e-29
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH..HHHHHHHHHHHHTS-BTTB--EEEEEE....SSSSEEEEEE--TTEBHHHHHHH CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateee..keelleeakimkklkhpnivkllgvct....keepllivteyvkgGdLlkfLrk 94 
                  + + +GeG fG ++e+++   ++ +e +Va+Kt+  ++++ +  +++  +ea++ k+l+h+n+vk++        +++  +iv+e+ k Gd+ + + +
   EFC35920.1 130 IIRIIGEGGFGIIFECQVL--NTPEEPNVAIKTIATGKNSIQkpTQDAENEANLVKQLDHQNVVKIYDTFQvdteHSSMFCIVMELYK-GDVMSIISE 224
                  6789***************..888899*******8766665545899********************9998765455559999*9986.788888888 PP

                  T..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE......TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEH CS
  Pkinase_Tyr  95 k..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse......nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkfts 184
                  +  + +++ l  + +++ q  ++++y++s++++Hrd+  +N+++++         v ++DfG+a++       ++k++   ++ +++pE l ++ +  
   EFC35920.1 225 SikSAATIPLPIIWKIISQTTQALNYVHSQQVMHRDIKPQNIFIRRrdidsnLIEVVLGDFGIAKEN----AHTTKNTYAGSLCYISPELLLNQPYGF 318
                  74345677788999*******************************9777753336889*******88....66777888899**************** PP

                  HHHHHHHHHHHHHHHTTSSGTTTTSH CS
  Pkinase_Tyr 185 ksDvWsfGvllwEiftlgespypglk 210
                  ++D+ s ++ +w +++l  sp +++ 
   EFC35920.1 319 ATDILS-SIKVWNVIELTVSPCAKYA 343
                  *****9.8*********999965543 PP

>> Cyclase  Putative cyclase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.2   0.0     2e-14     9e-11      17     136 .]     393     524 ..     325     524 .. 0.73

  Alignments for each domain:
  == domain 1  score: 42.2 bits;  conditional E-value: 2e-14
     Cyclase  17 p..........islsehtGTHlDapgHfaektide.lpleelvgpavvldvsakaaaedyeiitaedleaalakqgveikpgdi..vlirTgwskrled 102
                            i  ++h+GTH D p Hf ++ i e     ++ g ++vl++ ++ + ++ ei ++e++++a++k++  i++ +i   +i+T  ++  +d
  EFC35920.1 393 CngvcivtrnvILSNSHAGTHADQPKHFEKNPIVEyFHTLQYNGACLVLNLVEELK-NNLEI-SEEMFRNAIEKSK--IPKDKIlrCIIKTRSNQP-SD 486
                 0555555555455678************8865655222334666777777744322.46655.*********9999..777777447999977665.77 PP

     Cyclase 103 keky..rnpglseeaaewlaekg..vkavGvDtlsvDa 136
                 ++++  +   ++++aae+l ++   + ++G+Dt+s+D+
  EFC35920.1 487 EQEWtnDFAHFHPSAAEYLSRELpnLLLIGIDTPSIDH 524
                 8899666699***********987799*********96 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   2.5e-06     0.011     123     172 ..     240     291 ..     226     299 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.5e-06
         Kdo 123 llkavgrliaklhragvnHadlyaknillqqee..eeeaeiwliDldkarlr 172
                 ++ ++ ++ +  h+ +v+H+d+ ++ni+++ ++  ++ +e++l D+  a++ 
  EFC35920.1 240 IISQTTQALNYVHSQQVMHRDIKPQNIFIRRRDidSNLIEVVLGDFGIAKEN 291
                 567788888999********************98777788888888766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (605 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       855  (0.0476881); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 3377.24
//
Query:       EFC35921.1  [L=116]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0035   17.2   4.0     0.0046   16.8   4.0    1.1  1  Curto_V2         Curtovirus V2 protein
     0.0068   16.7  11.4     0.0073   16.6  11.4    1.0  1  RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc3
  ------ inclusion threshold ------
      0.029   13.6   0.1      0.035   13.3   0.1    1.0  1  Endonuc-BsobI    Restriction endonuclease BsobI
      0.038   13.7   3.5      0.049   13.3   3.5    1.1  1  tRNA_bind_2      Possible tRNA binding domain
      0.042   13.5   0.2      0.059   13.1   0.2    1.3  1  MiaE_2           tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like
          2    6.4  13.8        2.1    6.4  13.8    1.1  1  DNA_pol_phi      DNA polymerase phi
        2.4    7.4   9.8        2.6    7.3   9.8    1.1  1  NOA36            NOA36 protein


Domain annotation for each model (and alignments):
>> Curto_V2  Curtovirus V2 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   4.0   1.8e-06    0.0046      49     124 ..      34     109 ..      26     111 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.8e-06
    Curto_V2  49 vflqfqkevkkllklkvtfsrkcely.ekiykkyls..dvpekkgelskvvveeeedyyefekipmeeacdkdedsevk 124
                  +l++++ +   l+   ++s k   y +k yk  +   ++ e+  e++  +veeee+     + p ee    d+++ev+
  EFC35921.1  34 LYLEIKQAIDTHLRIASDYSNKITKYlDKKYKDQVVadNADEEEEEVADRMVEEEEE---NTEEPAEEEEATDDGNEVE 109
                 68999999999***********9887578999876433678999999*******999...4455888888888888887 PP

>> RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc31
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6  11.4   2.9e-06    0.0073     112     210 ..      14     111 ..       3     116 .] 0.44

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 2.9e-06
  RNA_pol_3_Rpc31 112 ylkkertlpklderpyvkefFPkELwptlkdgkd...e.....kkeikgkskkkk....eadeedeegkelleklkelaeeeddeeekkekede 193
                      y+ ++ tl++ +    ++  +P++L+  +k++ d   +     +++i++  +kk      ad+ dee++e+ +++ e +ee+ +  e+ e+e+ 
       EFC35921.1  14 YRIPKDTLKSRS----HRTSLPRDLYLEIKQAIDthlRiasdySNKITKYLDKKYkdqvVADNADEEEEEVADRMVEEEEENTE--EPAEEEE- 100
                      444444544444....5589*********8666665514455533344444444322232233333333333333322222222..2333333. PP

  RNA_pol_3_Rpc31 194 eeeeeeeeddefdddde 210
                              dd  + +++
       EFC35921.1 101 ------ATDDGNEVEED 111
                      ......33333333333 PP

>> Endonuc-BsobI  Restriction endonuclease BsobI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   1.4e-05     0.035      42     107 ..      20      87 ..      12      89 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.4e-05
  Endonuc-BsobI  42 alkslaskvktpadl.lnikd.irealltaaGlsdkalkylteedkveaikkliknflePagekfvee 107
                    +lks +++++ p+dl l+ik+ i + l  a+  s+k  kyl+++ k++++++   +  e  +++ vee
     EFC35921.1  20 TLKSRSHRTSLPRDLyLEIKQaIDTHLRIASDYSNKITKYLDKKYKDQVVADNADEEEEEVADRMVEE 87 
                    899***********978998648888999*********************998888888888888877 PP

>> tRNA_bind_2  Possible tRNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   3.5   1.9e-05     0.049     124     207 ..      30     113 ..      24     115 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.9e-05
                  HHHHHT--SSHHHHHHHHHHHHHHHHH-HHHHHHHHH-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  tRNA_bind_2 124 lekeLnlpsnQvlalFvkiirkvskalreilekaieeelpkekeeekaaeaeeeeakekelkpleesleeeLeeaakeveeklk 207
                  l ++L l+ +Q++    +i    s+ +++ l+k++++++ + ++ e+++e  ++ ++e+e ++ e   eee +++++evee+ +
   EFC35921.1  30 LPRDLYLEIKQAIDTHLRIASDYSNKITKYLDKKYKDQVVADNADEEEEEVADRMVEEEEENTEEPAEEEEATDDGNEVEEDSE 113
                  678999**************9999999999999999999999988777777888888888888888889999999999999876 PP

>> MiaE_2  tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.2   2.3e-05     0.059      86     140 ..      31      86 ..      14      95 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.3e-05
                 -SSHHHHHHHHHHHH.HHHHHHHHHHCCCS-HHHHHHHHHHS--HHHHHHHHHHHH CS
      MiaE_2  86 Padwleslvkayvgd.svaadfyrevaeyldadtrelvlavlddtghaevaeekvr 140
                 P d +  + +a  +   +a+d+  ++++yld + ++ v a  +d+++ eva + v+
  EFC35921.1  31 PRDLYLEIKQAIDTHlRIASDYSNKITKYLDKKYKDQVVADNADEEEEEVADRMVE 86 
                 555555555553322259********************************999875 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4  13.8    0.0008       2.1     621     681 ..      56     113 ..      25     115 .. 0.56

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0008
  DNA_pol_phi 621 lldvLearenkegqaelfedededeeddeeeeeeddeededse.edddeeesdedeededde 681
                  +++ L+++ +    +++++d+ ++ee++  +   ++ee++ +e  +++e ++d +e +ed+e
   EFC35921.1  56 ITKYLDKKYK----DQVVADNADEEEEEVADRMVEEEEENTEEpAEEEEATDDGNEVEEDSE 113
                  5555555544....555534444444444444444444444443333332333222233332 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   9.8     0.001       2.6     219     298 ..      27     106 ..       8     115 .. 0.46

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.001
       NOA36 219 etqetkdlslstrslkfgrqkqadgsddddddeedsdydaylkalasgddeddegdedddddddeedddeeeddedeeee 298
                  t+  +dl l +++      + a++  ++  +  d++y+++  a +++++e++ +d+  ++++++ ++  ee++ +++ +
  EFC35921.1  27 RTSLPRDLYLEIKQAIDTHLRIASDYSNKITKYLDKKYKDQVVADNADEEEEEVADRMVEEEEENTEEPAEEEEATDDGN 106
                 55555555555555444444433333333334455556655555555444444444444444443333333222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1930  (0.107647); expected 358.6 (0.02)
Passed bias filter:                      722  (0.04027); expected 358.6 (0.02)
Passed Vit filter:                        94  (0.0052429); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 718.39
//
Query:       EFC35922.1  [L=163]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.1e-22   79.4   0.0    2.6e-22   79.2   0.0    1.1  1  Alpha_adaptin_C  Alpha adaptin AP2, C-terminal domain
     0.0015   18.6   0.4      0.017   15.2   0.4    2.0  1  B2-adapt-app_C   Beta2-adaptin appendage, C-terminal sub-doma
     0.0015   18.6   0.0     0.0023   18.1   0.0    1.2  1  Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendag


Domain annotation for each model (and alignments):
>> Alpha_adaptin_C  Alpha adaptin AP2, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.2   0.0   4.3e-26   2.6e-22       8     112 ..      53     154 ..      45     155 .. 0.87

  Alignments for each domain:
  == domain 1  score: 79.2 bits;  conditional E-value: 4.3e-26
  Alpha_adaptin_C   8 ssedFfkrWkqlggapreaqkifklkaaekeideetvrkvl.eGfrlavlenvdpnpenivgagvlhtsesgkvgcLlrlepNkqakmvrltiR 100
                       +e+Ffk+W+ +g +++e+qkif  +      d +   kvl eGfrla+l+++d np+niv+ag +  +  gkv++Llrle N+ ++ +rlt++
       EFC35922.1  53 GAENFFKQWHAIG-KEQEVQKIFPCTPV--YSDVNACAKVLsEGFRLAILTGID-NPSNIVAAGSFFYDPVGKVNVLLRLEYNAPKQAYRLTVK 142
                      4899********7.778*******6644..4556667777779**********9.89************************************* PP

  Alpha_adaptin_C 101 atkeavpktllk 112
                      a+++++++++ +
       EFC35922.1 143 AQDATIAQQVFN 154
                      ********9875 PP

>> B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.4   2.8e-06     0.017       9     108 ..      55     156 ..      53     160 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.8e-06
  B2-adapt-app_C   9 eeFlekWkslpesneqsltlsnnvastspdaleekLqanniftiAkrgvegqqekl....YfsakltngilfLvellintsgksvkvsvKsedpe 99 
                     e+F ++W ++ +++e+++ ++ +++  +++a+ + L++     i   g +++ + +    +f+   + ++ +L+ l +n+++++++++vK++d++
      EFC35922.1  55 ENFFKQWHAIGKEQEVQKIFPCTPVYSDVNACAKVLSEGFRLAIL-TGIDNPSNIVaagsFFYD-PVGKVNVLLRLEYNAPKQAYRLTVKAQDAT 147
                     789999999998888888888766337888888888765433333.333333332222214444.66789*********88845*********** PP

  B2-adapt-app_C 100 vaplflqll 108
                     +a+++++++
      EFC35922.1 148 IAQQVFNYI 156
                     ****99876 PP

>> Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendage platform
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   3.8e-07    0.0023       9     115 .]      54     156 ..      44     156 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 3.8e-07
                      -S-HHHHHHHH-STT-EEEEEEE.SS---HHHHHHHHHHHHT-EE-TTTT---SS-SEEEEEEEEEETTS-..EEEEEEEEEE..SS.EEEEEE CS
  Coatomer_g_Cpla   9 vsnFeaaWeeleseaeavetfaL.ssvksleeavdkliellgmqplegsdkvpenassHtLklaGkfvgge..kvlvrarlalssskgvtlklt 99 
                      ++nF ++W ++++e+e+ + f     ++++++ ++ l e + +  l g d +p+n     +  aG f+ +   kv v +rl +++  + + +lt
       EFC35922.1  54 AENFFKQWHAIGKEQEVQKIFPCtPVYSDVNACAKVLSEGFRLAILTGID-NPSN-----IVAAGSFFYDPvgKVNVLLRLEYNA-PKQAYRLT 140
                      349*******************955667777777778899*********9.6655.....7789999997777**********98.5579**** PP

                      EEESSHHHHHHHHHH- CS
  Coatomer_g_Cpla 100 vRsedeevaelvlsav 115
                      v+++d+++a+ v + +
       EFC35922.1 141 VKAQDATIAQQVFNYI 156
                      ************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       481  (0.026828); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 933.70
//
Query:       EFC35923.1  [L=572]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.9e-28   97.9   0.1    6.9e-28   97.9   0.1    2.0  2  ELMO_CED12  ELMO/CED-12 family
  ------ inclusion threshold ------
      0.059   13.4   0.2      0.059   13.4   0.2    2.2  2  Daxx        Daxx N-terminal Rassf1C-interacting domain


Domain annotation for each model (and alignments):
>> ELMO_CED12  ELMO/CED-12 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.4       1.1   9.9e+03     132     152 ..     186     206 ..     171     210 .. 0.43
   2 !   97.9   0.1   7.7e-32   6.9e-28       4     121 ..     413     531 ..     410     561 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.1
  ELMO_CED12 132 klktnntkllssnlnafeelf 152
                 ++k++++k++s+++n+ ++ f
  EFC35923.1 186 HKKSTKKKSSSKTKNQHNRTF 206
                 222233344444444444444 PP

  == domain 2  score: 97.9 bits;  conditional E-value: 7.7e-32
  ELMO_CED12   4 ekkrktpldlenpeherlLkelwsalypdepeinstksrisekWkklGFqgedPatDFrgtGlLgLenLlyfaenheeefqkllsessrrpsee..... 97 
                 +k ++ ++d en +h++lL +l+++++ ++++i       +e+Wk lGFq+++P tDFrg+G+LgL+nLlyf++++++ f++   +++++ s       
  EFC35923.1 413 KKYCSKKFDIENDKHQKLLFSLYKCCT-QKKTIL----TEGEHWKFLGFQNTKPETDFRGAGILGLRNLLYFSKHYKKRFKNYFGKCTNEISVTddgtf 506
                 788999******************999.667776....89*************************************************9995567889 PP

  ELMO_CED12  98 .eypfavasinvtslllelleiekt 121
                  +ypf++a++nvt+lll+ l i  +
  EFC35923.1 507 tSYPFVIAGLNVTMLLLSFLGIGFQ 531
                 9****************99988433 PP

>> Daxx  Daxx N-terminal Rassf1C-interacting domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.2   6.6e-06     0.059       4      69 ..      70     130 ..      68     145 .. 0.83
   2 ?   -2.7   0.2      0.72   6.4e+03      15      30 ..     404     419 ..     399     444 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 6.6e-06
        Daxx   4 sakkekkvlkleneklfeeflelCkketedhPevvtflktrkqkaspeflasvefrnvlgrvlsra 69 
                 s++k k ++ ++ne  f+e+++l ++  +d P  + f ++r+qk sp        rn ++++l+r 
  EFC35923.1  70 SSEKRKTIYIINNENDFSEMMKLIQEIPQDKP--ILFRQQRHQKQSPRNQQ---ARNFITKILARK 130
                 6788999*************************..6799*******998654...566677777765 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.72
        Daxx  15 eneklfeeflelCkke 30 
                 e ++++e+f ++C+k+
  EFC35923.1 404 EKKQILEQFKKYCSKK 419
                 5667778888888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (572 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1456  (0.0812092); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 3624.73
//
Query:       EFC35924.1  [L=390]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.5e-53  180.4   0.0    4.2e-53  179.7   0.0    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.8e-15   57.1   0.2      4e-15   55.9   0.2    1.6  1  PAS_9          PAS domain
    5.2e-07   29.7   0.0    9.5e-07   28.8   0.0    1.4  1  PAS            PAS fold
  ------ inclusion threshold ------
      0.014   15.7   0.0      0.026   14.8   0.0    1.5  1  PAS_3          PAS fold
      0.015   14.8   0.0       0.03   13.7   0.0    1.5  1  HNOBA          Heme NO binding associated
       0.05   13.7   0.1      0.094   12.8   0.1    1.4  1  FlgT_M         Flagellar assembly protein T, middle domain
      0.093   13.0   0.0       0.19   12.0   0.0    1.4  1  PAS_4          PAS fold


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  179.7   0.0   1.7e-56   4.2e-53       3     182 ..     142     326 ..     140     327 .. 0.97

  Alignments for each domain:
  == domain 1  score: 179.7 bits;  conditional E-value: 1.7e-56
  Guanylate_cyc   3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp..eekaahaaklaelaLdmlealeevaves 96 
                    ae++++v+ +F+d+vgft+ls+  ++ e+v++Lne++  fd+l+d+++++k+ktiGd+y +v gl+  +++ +h ++++++++d ++ l+ ++ +s
     EFC35924.1 142 AEKFNDVSCFFSDMVGFTKLSTGIQASELVQMLNEIVIGFDDLTDKYNLEKIKTIGDSYFCVGGLHglNAQSDHPERILRFSIDTFDVLQRFNSKS 237
                    68899**************************************************************99************************999 PP

  Guanylate_cyc  97 ....keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182
                        +e++++rvGi+tG+v+agviG+kk+ yd+wG+t+n+Asrmes++ +g+iq+s++tye   + +f+++er + +vkGkg+ ++y+l+
     EFC35924.1 238 gkqpSEQINIRVGINTGSVIAGVIGRKKFAYDLWGDTINTASRMESNSIPGRIQISRSTYERVYDLGFTFEER-HLNVKGKGECIAYMLH 326
                    77777*****************************************************************998.69************97 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.9   0.2   1.6e-18     4e-15      13     104 .]       9     103 ..       2     103 .. 0.96

  Alignments for each domain:
  == domain 1  score: 55.9 bits;  conditional E-value: 1.6e-18
       PAS_9  13 ilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.......kerevevvlirkngetfwvlltaspvkdddgelvgiivilrDite 104
                 i+ +N+aa +++Gy+  e +g+s+ +lf  +++++++++++++++         k  + e+++irkn++ f+ ++++++   +++ +v   ++++Dit+
  EFC35924.1   9 IEIFNPAAQKIFGYNQTETIGRSLYQLF--EKNEQSKIKNLIDEMLVnaargdsKGDSIELECIRKNQTSFPSRVNIFATLHNSQSIVT--CFIKDITT 103
                 7799************************..***********************************************************..******95 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0   3.7e-10   9.5e-07      26     113 .]      12     101 ..       5     101 .. 0.93

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 3.7e-10
                 ECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEEEEEEETTEEEEEEEEEEEES CS
         PAS  26 vNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevraspvrdaggeilgflgvlrdi 113
                 +N+aa++++G+++ e +g+sl+ l+  +++++ + l+ + l ++ ++ ++  s++l    ++++ ++ +v+   +++ ++    + ++++di
  EFC35924.1  12 FNPAAQKIFGYNQTETIGRSLYQLFEKNEQSKIKNLIDEMLVNAARGDSKGDSIELecirKNQTSFPSRVNIFATLHNSQS--IVTCFIKDI 101
                 8**********************************************99999999999999**********9999999998..699999997 PP

>> PAS_3  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0     1e-05     0.026       4      81 ..      12      93 ..       9      99 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1e-05
       PAS_3  4 vserveeilGyspeellgkveswldlvhpeDrervrealqeal.......kkgepyegeyRirrkdGeyrwveararvi.rdengk 81
                 +++ ++i+Gy + e +g+  s+++l    +++++++ ++e+l       +kg   ++e  ++rk+ + +  +  ++++ +++++ 
  EFC35924.1 12 FNPAAQKIFGYNQTETIGR--SLYQLFEKNEQSKIKNLIDEMLvnaargdSKGD--SIELECIRKNQTSFPSRVNIFATlHNSQSI 93
                58999**************..*******************99999875544444..788888999988777777776665555555 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   1.2e-05      0.03     193     221 .]     106     134 ..      89     134 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.2e-05
       HNOBA 193 esmkeleeekkrtdeLLysmiPkevAerL 221
                 + ++ l eekk ++eLL +++P  vA++L
  EFC35924.1 106 KHNSLLTEEKKHSEELLLNILPSAVASKL 134
                 667889********************987 PP

>> FlgT_M  Flagellar assembly protein T, middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   3.7e-05     0.094      31     111 ..      22     112 ..       8     120 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.7e-05
      FlgT_M  31 ydlgkalsrklaqelnqqsslavleatsqalid..d..........aptseslsnkeqlenirsLaeqtdsQYvlsgvIrDlsveeeeassls 111
                 y+  +++ r l q +++++++ + +++ + l++  +          +    ++++++ +++++  a+ ++sQ ++   I+D+++e++++s l+
  EFC35924.1  22 YNQTETIGRSLYQLFEKNEQSKIKNLIDEMLVNaaRgdskgdsielECI--RKNQTSFPSRVNIFATLHNSQSIVTCFIKDITTEKKHNSLLT 112
                 6667889999999999999999999999988886525678877755333..33444478899999**********************999765 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   7.3e-05      0.19      18      60 ..      10      52 ..       4      59 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 7.3e-05
       PAS_4 18 lyaNaaaaelfgappeellGktlaellpeedaarleralrrvl 60
                +  N+aa+++fg+ + e +G++l++l+ +  +  + + ++++l
  EFC35924.1 10 EIFNPAAQKIFGYNQTETIGRSLYQLFEKNEQSKIKNLIDEML 52
                557**************************99999999888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (390 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       665  (0.0370907); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2312.19
//
Query:       EFC35925.1  [L=157]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-58  194.0   1.2    1.6e-20   72.6   0.1    3.1  3  DUF4116          Domain of unknown function (DUF4116)
    0.00044   19.6   0.1        0.1   11.9   0.0    2.3  2  6PF2K            6-phosphofructo-2-kinase
     0.0031   17.6   0.0        8.5    6.5   0.0    3.0  3  Rsbr_N           Rsbr N terminal
  ------ inclusion threshold ------
      0.017   15.2   0.0        4.4    7.4   0.0    2.8  4  YafO_toxin       Toxin YafO, type II toxin-antitoxin system
      0.025   14.6   0.5         29    4.6   0.0    3.3  3  DUF5033          Domain of unknown function (DUF5033)
       0.06   13.2   0.0       0.22   11.4   0.0    1.8  1  Sec7_N           Guanine nucleotide exchange factor in Golgi 
       0.06   13.2   0.2        1.6    8.6   0.0    2.1  2  Peptidase_M10_C  Peptidase M10 serralysin C terminal
       0.17   12.0   4.2         25    5.0   0.0    4.1  6  DUF3929          Protein of unknown function (DUF3929)
       0.19   11.7   0.3         40    4.2   0.0    3.4  3  TP1              Nuclear transition protein 1
       0.28   10.9   3.1         48    3.8   0.0    4.0  4  Vta1_C           Vta1 C-terminal domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.6   0.0   1.8e-18   3.1e-15       1      49 []       7      55 ..       7      55 .. 0.96
   2 !   72.6   0.1   8.7e-24   1.6e-20       1      47 [.      57     103 ..      57     105 .. 0.96
   3 !   63.6   0.0   5.5e-21   9.9e-18       1      44 [.     107     150 ..     107     152 .. 0.97

  Alignments for each domain:
  == domain 1  score: 55.6 bits;  conditional E-value: 1.8e-18
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                Dr  vleavk+ g+al+y++e++k+D+e++l+Avk ng  l y++ +L+
  EFC35925.1  7 DRTYVLEAVKQRGNALEYVDESFKKDREFILEAVKHNGWELLYVDSSLK 55
                7778****************************************99986 PP

  == domain 2  score: 72.6 bits;  conditional E-value: 8.7e-24
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 DrEivleavk+ngsal+y++++Lk+D+eivl+Avkqng+al+ya+  
  EFC35925.1  57 DREIVLEAVKHNGSALEYADSSLKKDREIVLEAVKQNGSALKYADSL 103
                 9******************************************9865 PP

  == domain 3  score: 63.6 bits;  conditional E-value: 5.5e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 DrEivle vk+ngsalky++++Lk+D+eivl+Avkq+g+a  ya
  EFC35925.1 107 DREIVLEFVKHNGSALKYVDSSLKKDREIVLEAVKQCGHAVQYA 150
                 9***************************************9998 PP

>> 6PF2K  6-phosphofructo-2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.0   5.6e-05       0.1     108     157 ..      29      78 ..      25      93 .. 0.84
   2 !    5.6   0.0    0.0048       8.5     109     153 ..     105     149 ..      90     156 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.6e-05
                 SHHHHHHHHHHHHHTT-EEEEEEEE-.-HHHHHHHHHHHHTTTSGGGTTS- CS
       6PF2K 108 trerRklilefveennlkvlflesic.sdeeiikeNikevklsspDYkdke 157
                  +++R++ile v++n+ + l+++s+  +d+ei+ e +k+  +    Y+d++
  EFC35925.1  29 FKKDREFILEAVKHNGWELLYVDSSLkKDREIVLEAVKHNGSA-LEYADSS 78 
                 689*******************98752799***9999988777.7788766 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0048
                 HHHHHHHHHHHHHTT-EEEEEEEE-.-HHHHHHHHHHHHTTTSGGG CS
       6PF2K 109 rerRklilefveennlkvlflesic.sdeeiikeNikevklsspDY 153
                 + +R+++lefv++n+    +++s+  +d+ei+ e +k+       Y
  EFC35925.1 105 KRDREIVLEFVKHNGSALKYVDSSLkKDREIVLEAVKQCGHA-VQY 149
                 789************99999997652799***9999987765.555 PP

>> Rsbr_N  Rsbr N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0    0.0048       8.5      61      93 ..      34      67 ..      11      68 .. 0.79
   2 ?    4.1   0.0     0.026        47      68      96 ..      67      95 ..      63     116 .. 0.79
   3 ?    4.5   0.0     0.019        35      68      93 ..     117     142 ..     108     155 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0048
                HHHHHHH.HTT--HHHHHHHHHHHHHHHHHHHHH CS
      Rsbr_N 61 efaerlv.qlGwpLkyltkgLqefrkvvlellse 93
                ef   +v ++Gw L y+ ++L++ r++vle++++
  EFC35925.1 34 EFILEAVkHNGWELLYVDSSLKKDREIVLEAVKH 67
                4554444279******************998865 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.026
                HTT--HHHHHHHHHHHHHHHHHHHHH..T CS
      Rsbr_N 68 qlGwpLkyltkgLqefrkvvlellseedd 96
                ++G  L+y  ++L++ r++vle+++++ +
  EFC35925.1 67 HNGSALEYADSSLKKDREIVLEAVKQNGS 95
                7899*******************999653 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.019
                 HTT--HHHHHHHHHHHHHHHHHHHHH CS
      Rsbr_N  68 qlGwpLkyltkgLqefrkvvlellse 93 
                 ++G  Lky+ ++L++ r++vle++++
  EFC35925.1 117 HNGSALKYVDSSLKKDREIVLEAVKQ 142
                 68*******************99987 PP

>> YafO_toxin  Toxin YafO, type II toxin-antitoxin system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.0    0.0024       4.4      51      90 ..      16      55 ..       2      64 .. 0.78
   2 ?    3.5   0.0      0.04        72      53      80 ..      43      70 ..      29      87 .. 0.73
   3 ?    3.8   0.0     0.032        58      51      81 ..      91     121 ..      76     138 .. 0.81
   4 ?    2.1   0.0      0.11     2e+02      48      80 ..     113     145 ..      98     153 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0024
  YafO_toxin 51 rtSdayLvYckgavnsnryllisilkpeaheqardeslle 90
                +  ++ L Y+   ++++r  ++ ++k++++e +   s l+
  EFC35925.1 16 KQRGNALEYVDESFKKDREFILEAVKHNGWELLYVDSSLK 55
                45567899***********************987555555 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.04
  YafO_toxin 53 SdayLvYckgavnsnryllisilkpeah 80
                ++  L+Y+   ++++r +++ ++k+++ 
  EFC35925.1 43 NGWELLYVDSSLKKDREIVLEAVKHNGS 70
                4556888888888888888888888865 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.032
  YafO_toxin  51 rtSdayLvYckgavnsnryllisilkpeahe 81 
                 + +++ L Y+  +++++r +++ ++k+++  
  EFC35925.1  91 KQNGSALKYADSLFKRDREIVLEFVKHNGSA 121
                 56778899*******************9755 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.11
  YafO_toxin  48 qfkrtSdayLvYckgavnsnryllisilkpeah 80 
                  f + +++ L Y+   ++++r +++ ++k+ +h
  EFC35925.1 113 EFVKHNGSALKYVDSSLKKDREIVLEAVKQCGH 145
                 444556666777777777777777777777666 PP

>> DUF5033  Domain of unknown function (DUF5033)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.15   2.7e+02      41      64 ..       9      28 ..       4      44 .. 0.70
   2 ?    4.6   0.0     0.016        29      21      56 ..      64      99 ..      58     112 .. 0.79
   3 ?    4.1   0.0     0.022        40      20      54 ..     113     147 ..     101     152 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.15
     DUF5033 41 devLeaLrkntnakeecesesveg 64
                  vLea+++ +na e +    +e+
  EFC35925.1  9 TYVLEAVKQRGNALEYV----DES 28
                57999999999998763....333 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.016
     DUF5033 21 svtynnsdlkdvPavsleemdevLeaLrkntnakee 56
                 v +n s l+   + + ++ + vLea+++n+ a + 
  EFC35925.1 64 AVKHNGSALEYADSSLKKDREIVLEAVKQNGSALKY 99
                5566777788888888999999********998765 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.022
     DUF5033  20 esvtynnsdlkdvPavsleemdevLeaLrkntnak 54 
                 e v +n s lk v + + ++ + vLea+++ ++a 
  EFC35925.1 113 EFVKHNGSALKYVDSSLKKDREIVLEAVKQCGHAV 147
                 66778999999*******************98875 PP

>> Sec7_N  Guanine nucleotide exchange factor in Golgi transport N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00012      0.22      42     133 ..      20     116 ..       4     150 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00012
      Sec7_N  42 svlsnhgdvfrkhpel.lqllkqklcplLlknlsespsfpvferslrivllLlkkfrseLktEievflsllililles....dssl.wqrvlaLeilr 133
                 ++l+  ++ f+k  e+ l+++k++  +lL+   s +++ ++++ +++     l++  s+Lk++ e++l+ + +         ds + + r+++Le+++
  EFC35925.1  20 NALEYVDESFKKDREFiLEAVKHNGWELLYVDSSLKKDREIVLEAVKHNGSALEYADSSLKKDREIVLEAVKQNGS-AlkyaDSLFkRDREIVLEFVK 116
                 5788888999999999899***********9999999999999999999999999999999999999998877773.335433333567777777654 PP

>> Peptidase_M10_C  Peptidase M10 serralysin C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.045        81     128     178 ..      12      61 ..       6      77 .. 0.75
   2 ?    8.6   0.0   0.00087       1.6     125     193 .]      84     154 ..      68     154 .. 0.76

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.045
                      -TTSHHHHTS-EE-SS--S-TTEEEEEEETTTTEEEEEEESSSS.SS-SEE CS
                      xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M10_C 128 lsaltknaknlqfvdeftgkageillrynevlnitelaidlsgelenadfl 178
                      l a++++ ++l++vde  +k  e +l+  +++    l++d s + ++ +++
       EFC35925.1  12 LEAVKQRGNALEYVDESFKKDREFILEAVKHNGWELLYVDSSLK-KDREIV 61 
                      56778888889999999999999999988888888888887765.444444 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00087
                      EEE-TTSHHHHTS-EE-SS--S-TTEEEEEEETTTTEEEEEEESSSS.SS-SE...EEEEES---G.GGEE- CS
                      xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxx RF
  Peptidase_M10_C 125 kidlsaltknaknlqfvdeftgkageillrynevlnitelaidlsgelenadf...lvkivGqkkleadviv 193
                      +i l a+++n ++l++ d++ ++  ei+l++ +++  +  ++d s + ++ ++   +vk  G++ + ad ++
       EFC35925.1  84 EIVLEAVKQNGSALKYADSLFKRDREIVLEFVKHNGSALKYVDSSLK-KDREIvleAVKQCGHAVQYADLFI 154
                      488999*************************9988887777887755.334431115667777777777765 PP

>> DUF3929  Protein of unknown function (DUF3929)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.5   2.7e+03      21      32 ..       7      18 ..       5      23 .. 0.83
   2 ?    4.1   0.1     0.026        47       7      32 ..      18      43 ..       9      50 .. 0.88
   3 ?    0.2   0.0      0.43   7.7e+02      20      32 ..      56      68 ..      43      73 .. 0.83
   4 ?   -1.5   0.0       1.5   2.7e+03      19      31 ..      80      92 ..      67      93 .. 0.74
   5 ?    5.0   0.0     0.014        25       7      32 ..      93     118 ..      90     127 .. 0.88
   6 ?    1.5   0.0      0.18   3.2e+02       7      31 ..     118     142 ..     117     148 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.5
     DUF3929 21 dqnkvlervknr 32
                d+  vle vk+r
  EFC35925.1  7 DRTYVLEAVKQR 18
                888899999987 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.026
     DUF3929  7 dGktikdvkefyyrdqnkvlervknr 32
                 G++++ v e + +d++ +le vk++
  EFC35925.1 18 RGNALEYVDESFKKDREFILEAVKHN 43
                588899999***************96 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.43
     DUF3929 20 rdqnkvlervknr 32
                +d++ vle vk++
  EFC35925.1 56 KDREIVLEAVKHN 68
                799999****995 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 1.5
     DUF3929 19 yrdqnkvlervkn 31
                 +d++ vle vk+
  EFC35925.1 80 KKDREIVLEAVKQ 92
                5788999999986 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.014
     DUF3929   7 dGktikdvkefyyrdqnkvlervknr 32 
                 +G ++k    ++ rd++ vle vk++
  EFC35925.1  93 NGSALKYADSLFKRDREIVLEFVKHN 118
                 888899999999************96 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.18
     DUF3929   7 dGktikdvkefyyrdqnkvlervkn 31 
                 +G ++k v     +d++ vle vk+
  EFC35925.1 118 NGSALKYVDSSLKKDREIVLEAVKQ 142
                 7889999999999*********996 PP

>> TP1  Nuclear transition protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.09   1.6e+02      22      39 ..      64      81 ..      56      86 .. 0.88
   2 ?    0.7   0.0      0.28   4.9e+02      22      37 ..      89     103 ..      85     109 .. 0.76
   3 ?    4.2   0.0     0.022        40      23      39 ..     115     131 ..     113     146 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.09
         TP1 22 GvkrGGskrkyrkGslks 39
                 vk  Gs   y   slk 
  EFC35925.1 64 AVKHNGSALEYADSSLKK 81
                69**************96 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.28
         TP1  22 GvkrGGskrkyrkGsl 37 
                  vk+ Gs  ky   sl
  EFC35925.1  89 AVKQNGSALKYAD-SL 103
                 69*********75.34 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.022
         TP1  23 vkrGGskrkyrkGslks 39 
                 vk  Gs  ky   slk 
  EFC35925.1 115 VKHNGSALKYVDSSLKK 131
                 8999***********95 PP

>> Vta1_C  Vta1 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.027        48      11      22 ..      65      76 ..      63      78 .. 0.87
   2 ?    1.8   0.1      0.11   1.9e+02      12      22 ..      91     101 ..      89     102 .. 0.81
   3 ?    2.5   0.0     0.066   1.2e+02      12      22 ..     116     126 ..     114     128 .. 0.86
   4 ?   -1.2   0.0      0.97   1.7e+03      26      33 ..     139     146 ..     136     152 .. 0.55

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.027
      Vta1_C 11 aKfAiSALqYeD 22
                 K+  SAL+Y D
  EFC35925.1 65 VKHNGSALEYAD 76
                58999*****99 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.11
      Vta1_C  12 KfAiSALqYeD 22 
                 K+  SAL+Y D
  EFC35925.1  91 KQNGSALKYAD 101
                 6667*****98 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.066
      Vta1_C  12 KfAiSALqYeD 22 
                 K+  SAL+Y D
  EFC35925.1 116 KHNGSALKYVD 126
                 8999*****88 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 0.97
      Vta1_C  26 AiknLqeA 33 
                 A+k++  A
  EFC35925.1 139 AVKQCGHA 146
                 55555433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (157 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       556  (0.0310112); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 1027.87
//
Query:       EFC35926.1  [L=819]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-05   24.9  20.1    0.00041   20.7   5.4   11.8 12  EGF_2     EGF-like domain
     0.0012   18.6   0.0       0.11   12.3   0.0    3.4  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5  17.0   0.00014       1.3       1      32 []      19      47 ..      19      47 .. 0.87
   2 ?   -6.6   6.9         2   1.8e+04      13      32 .]      58      77 ..      52      77 .. 0.62
   3 ?   -0.3   9.7      0.17   1.5e+03       1      32 []      81     106 ..      81     106 .. 0.80
   4 ?   -1.1   0.7      0.28   2.5e+03      23      30 ..     253     260 ..     252     261 .. 0.87
   5 !   20.7   5.4   4.6e-08   0.00041       6      32 .]     451     476 ..     447     476 .. 0.90
   6 !   19.0   6.7   1.5e-07    0.0014       5      32 .]     489     515 ..     485     515 .. 0.90
   7 ?   -1.9   0.3       0.5   4.5e+03      22      28 ..     532     538 ..     523     544 .. 0.73
   8 ?   -2.0   8.9      0.54   4.8e+03       1      32 []     548     573 ..     544     573 .. 0.79
   9 ?    2.2  11.6     0.026   2.3e+02      13      32 .]     585     605 ..     578     605 .. 0.81
  10 ?   -0.4  11.9      0.18   1.6e+03       1      32 []     609     634 ..     609     634 .. 0.85
  11 ?   -2.8  10.6      0.98   8.8e+03      13      32 .]     645     664 ..     638     664 .. 0.78
  12 ?   -7.1   7.8         2   1.8e+04      12      32 .]     673     693 ..     666     693 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00014
       EGF_2  1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                C + +++C  +G+C+   G+C+C+sgy G +C
  EFC35926.1 19 CAPKCTNCA-NGQCI--DGVCVCNSGYGGVNC 47
                766677776.7****..************999 PP

  == domain 2  score: -6.6 bits;  conditional E-value: 2
       EGF_2 13 tCvnqcGqC.dCdsgyqGktC 32
                +C ++   C +C +  +G+tC
  EFC35926.1 58 KCSTPY-LCsSCLPRTFGATC 77
                455444.56348888889998 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.17
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C +++++C+ + tC       +Cd+g++G tC
  EFC35926.1  81 CIPNCLTCSDDKTCT------KCDAGFTGQTC 106
                 666677777777777......59********* PP

  == domain 4  score: -1.1 bits;  conditional E-value: 0.28
       EGF_2  23 CdsgyqGk 30 
                 C+sg++G 
  EFC35926.1 253 CPSGFFGV 260
                 9*****95 PP

  == domain 5  score: 20.7 bits;  conditional E-value: 4.6e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G+C++    C+C++gy G +C
  EFC35926.1 451 NVCSGNGICEEMD-MCYCKTGYAGINC 476
                 68********677.9************ PP

  == domain 6  score: 19.0 bits;  conditional E-value: 1.5e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g G+C +++ +C+C++gy G +C
  EFC35926.1 489 ASVCSGIGSCLSPN-NCSCPNGYNGTNC 515
                 578********999.8************ PP

  == domain 7  score: -1.9 bits;  conditional E-value: 0.5
       EGF_2  22 dCdsgyq 28 
                 +C+sg++
  EFC35926.1 532 SCKSGFY 538
                 4899988 PP

  == domain 8  score: -2.0 bits;  conditional E-value: 0.54
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C  ++e C+  +tC+      +C +g  G +C
  EFC35926.1 548 CLVNCEVCSSSETCN------KCLDGLKGQYC 573
                 4445999********......47888888887 PP

  == domain 9  score: 2.2 bits;  conditional E-value: 0.026
       EGF_2  13 tCvnqcGqC.dCdsgyqGktC 32 
                 tC +++G C +C+ gy+G +C
  EFC35926.1 585 TCSTSTGDClECNEGYYGSYC 605
                 79889999966********** PP

  == domain 10  score: -0.4 bits;  conditional E-value: 0.18
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C++++  C+   +C   +    C sg++G+tC
  EFC35926.1 609 CPSNCKSCSSEVSCS--T----CRSGWTGPTC 634
                 888888888888888..7....********** PP

  == domain 11  score: -2.8 bits;  conditional E-value: 0.98
       EGF_2  13 tCvnqcGqC.dCdsgyqGktC 32 
                 tC +++ qC +C++g +G +C
  EFC35926.1 645 TCSSPN-QCsKCFNGLYGSDC 664
                 577666.8956********** PP

  == domain 12  score: -7.1 bits;  conditional E-value: 2
       EGF_2  12 GtCvnqcGqC.dCdsgyqGktC 32 
                 ++C+n++  C  C++  +G  C
  EFC35926.1 673 ESCINST-SClTCPPYSSGSMC 693
                 4677777.57448999999888 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.0   1.3e-05      0.11       2      24 ..     223     245 ..     222     252 .. 0.89
   2 ?    0.8   0.0     0.051   4.5e+02      15      26 ..     290     303 ..     287     307 .. 0.78
   3 ?    0.2   0.0      0.08   7.2e+02       9      21 ..     338     350 ..     337     355 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.3e-05
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWG 24 
                 ++v  ++y+s++Lt +G+V+++G
  EFC35926.1 223 IDVYTNNYFSFFLTKEGNVRSFG 245
                 68889*****************9 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.051
      RCC1_2  15 tedGeVlcWG..sN 26 
                 +e+ ++++WG  s+
  EFC35926.1 290 RESRRLYGWGpiSD 303
                 58899*****6655 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.08
      RCC1_2   9 yHscaLtedGeVl 21 
                 y+ + L+e+G+++
  EFC35926.1 338 YFVLYLMESGKIF 350
                 67899******97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (819 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1061  (0.0591779); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.82u 0.34s 00:00:01.15 Elapsed: 00:00:00.58
# Mc/sec: 4236.07
//
Query:       EFC35927.1  [L=382]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   15.5   2.3      0.013   15.5   2.3    3.1  3  Apis_Csd  Complementary sex determiner protein
       0.17   12.3   2.8       0.96    9.9   1.3    2.5  2  Eaf7      Chromatin modification-related protein EAF7


Domain annotation for each model (and alignments):
>> Apis_Csd  Complementary sex determiner protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -9.2  20.0         2   1.8e+04      49      80 ..      67     104 ..      34     133 .. 0.67
   2 ?   15.5   2.3   1.5e-06     0.013      41      84 ..     219     267 ..     206     300 .. 0.79
   3 ?   -2.8   0.3      0.64   5.7e+03      55      92 ..     354     378 ..     337     382 .] 0.41

  Alignments for each domain:
  == domain 1  score: -9.2 bits;  conditional E-value: 2
    Apis_Csd  49 isslsnlsnnynyn.nnynnyn.....nynklyyniny 80 
                 +ss +n+ n +n n nn nn++     +y+++y   ny
  EFC35927.1  67 LSSITNNNNTNNMNnNNMNNNEmieeeEYEEYYLPENY 104
                 34444433333333033344333333455555655566 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 1.5e-06
    Apis_Csd  41 ersrekkiisslsn...lsnnynynnnynnynnynkl..yyninyieqi 84 
                 +rs e+ ii++lsn   l+nn+n nnn nn  n n      n+++ eq+
  EFC35927.1 219 KRSAESMIINQLSNlmkLYNNNNMNNNMNNTTNMNGNgnNVNVKFYEQL 267
                 6899999998777622268888888888888766655337788888886 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 0.64
    Apis_Csd  55 lsnnynynnnynnynnynklyyninyieqipvpvyygn 92 
                 ++               n     in i+ i   + y n
  EFC35927.1 354 NT-------------TTNTIIKPINSIKPIKHLIMYQN 378
                 11.............23333344444444444444433 PP

>> Eaf7  Chromatin modification-related protein EAF7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   1.3   0.00011      0.96      55     104 ..      46     103 ..      27     105 .. 0.81
   2 ?    1.0   0.0     0.062   5.6e+02      51      87 ..     222     258 ..     208     313 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00011
        Eaf7  55 iwekLktlYdLkaldelenekeeeeeeeekekee........kakeleekkdFeLPed 104
                 i  k+k+ ++++ l++++++  ++ +++++++++        +  e ee++++ LPe+
  EFC35927.1  46 ISVKIKKNFNMNNLNNMNKTSLSSITNNNNTNNMnnnnmnnnEMIEEEEYEEYYLPEN 103
                 77899************9997777666665555577888877888999999999*986 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.062
        Eaf7  51 siediwekLktlYdLkaldelenekeeeeeeeekeke 87 
                    +i ++L++l +L   ++++n+ +++++ + + ++
  EFC35927.1 222 AESMIINQLSNLMKLYNNNNMNNNMNNTTNMNGNGNN 258
                 5567788888777777777777775544444444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (382 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1756  (0.0979419); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 2159.67
//
Query:       EFC35928.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0037   17.0   1.0     0.0055   16.4   1.0    1.2  1  Casc1_N   Cancer susceptibility candidate 1 N-terminus
  ------ inclusion threshold ------
       0.56   10.3   6.6        1.1    9.4   6.6    1.5  1  AT_hook   AT hook motif


Domain annotation for each model (and alignments):
>> Casc1_N  Cancer susceptibility candidate 1 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   1.0   6.2e-07    0.0055      77     122 ..     137     182 ..     136     200 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 6.2e-07
     Casc1_N  77 ecdglPdptdekeiNtflslwseeeeedieevmetctlvlklieeL 122
                 +c+++P  t+   +N+f++  s++++ di++ +++c++ ++   ++
  EFC35928.1 137 NCHHSPSSTNNNNVNNFIMMKSNDDNIDIDNNTRRCSMFVNYQCDV 182
                 7***********************************9988877766 PP

>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.6   0.00012       1.1       1      12 [.      29      40 ..      29      41 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00012
     AT_hook  1 kRkRGRPrKaat 12
                kR+RGRP+K+ +
  EFC35928.1 29 KRRRGRPAKNDP 40
                8********976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       763  (0.0425568); expected 358.6 (0.02)
Passed bias filter:                      201  (0.0112109); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.64
# Mc/sec: 1062.43
//
Query:       EFC35929.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.5e-07   29.0   0.2    1.5e-06   28.1   0.2    1.5  1  RWP-RK          RWP-RK domain
  ------ inclusion threshold ------
       0.21   11.6   2.3       0.39   10.8   1.9    1.6  1  Pinin_SDK_memA  pinin/SDK/memA/ protein conserved region


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.1   0.2   1.6e-10   1.5e-06       1      47 [.      18      68 ..      18      69 .. 0.86

  Alignments for each domain:
  == domain 1  score: 28.1 bits;  conditional E-value: 1.6e-10
      RWP-RK  1 nltleelqqyFslplkeAAksLgvskttLKricR....elgIsRWPyRkik 47
                +ltl+el+++ +l+ ++AAk Lg s+ +L+ + +    el + RWP  k +
  EFC35929.1 18 QLTLDELKSVLHLSQEQAAKVLGTSSFKLRSLFKkhreELSMVRWPTQKAR 68
                58***********************9888776665555999*****99975 PP

>> Pinin_SDK_memA  pinin/SDK/memA/ protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   1.9   4.3e-05      0.39      58     124 ..      65     136 ..      29     141 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 4.3e-05
  Pinin_SDK_memA  58 rekreeleeerraeqkelraleeklelke......lmetwhenkkalanflrTktePpiyYlPwkltekteel 124
                     ++ r+++ ++++++ + + ++ee+  ++e      ++    +++ +  n   T+ eP+i YlP+ l  ++  +
      EFC35929.1  65 QKARQQMLTNNNNNNIIV-KEEEEFPRDEndfpifKKSLIYKQQIKKGNNPFTSIEPKILYLPSPLENNQHNV 136
                     233333333333333333.44555545555677777777777888888888**************99988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       755  (0.0421105); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.35s 00:00:00.92 Elapsed: 00:00:00.54
# Mc/sec: 2053.49
//
Query:       EFC35930.1  [L=284]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.04   13.8   0.9      0.071   13.0   0.2    1.8  2  DUF1508   Domain of unknown function (DUF1508)


Domain annotation for each model (and alignments):
>> DUF1508  Domain of unknown function (DUF1508)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   3.9e-06     0.071      12      42 ..      65      95 ..      64      97 .. 0.93
   2 ?   -3.6   0.0      0.58     1e+04      10      18 ..     111     119 ..     110     122 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.9e-06
                -TTS-EEEEEEEBSSHHHHHHHHHHHHHHTT CS
     DUF1508 12 aaNgevIatsegYsskaaaenGIesVkknap 42
                ++N++ I +s  ++ k++a n I sV + +p
  EFC35930.1 65 HNNNNNIENSPSFTRKSSASNEISSVLSSSP 95
                89************************88776 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 0.58
                 EE-TTS-EE CS
     DUF1508  10 LkaaNgevI 18 
                  +++N++ +
  EFC35930.1 111 IRHSNNQFL 119
                 689999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (284 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1014  (0.0565564); expected 358.6 (0.02)
Passed bias filter:                      220  (0.0122706); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 1689.52
//
Query:       EFC35931.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.4e-05   22.9   1.5       0.74   10.0   0.0    3.9  3  Arm            Armadillo/beta-catenin-like repeat
  ------ inclusion threshold ------
      0.016   15.4   0.3      0.038   14.2   0.3    1.6  1  PBP_GOBP       PBP/GOBP family
      0.032   13.5   0.4      0.054   12.7   0.4    1.4  1  NTP_transf_7   Nucleotidyltransferase
      0.083   12.9   6.9       0.94    9.4   0.1    3.6  3  UNC45-central  Myosin-binding striated muscle assembly centra
      0.091   12.6   0.0       0.16   11.8   0.0    1.3  1  Inhibitor_I48  Peptidase inhibitor clitocypin


Domain annotation for each model (and alignments):
>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0     0.073   2.6e+02       6      27 ..      53      74 ..      51      84 .. 0.76
   2 !    7.5   0.1    0.0012       4.3      13      40 ..     104     131 ..      99     132 .. 0.87
   3 !   10.0   0.0   0.00021      0.74       4      41 .]     276     312 ..     272     312 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.073
                HHHHHTTHHHHHHHHTTTSSHH CS
         Arm  6 davieaGavppLvrLLssedee 27
                +++++ G v+  v+ L++++ e
  EFC35931.1 53 KLLVKEGFVEKMVSILENPNSE 74
                5799*************55543 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0012
                 HHHHHHHHTTTSSHHHHHHHHHHHHHHT CS
         Arm  13 avppLvrLLssedeevqeeAawALsNLa 40 
                 a+++  ++L++  +++ + Aa+A++N+ 
  EFC35931.1 104 ALKVVSNFLTHAVDSIAQSAAGAVGNIV 131
                 48888999******************95 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00021
                 HHHHHHHTTHHHHHHHHTTTSSHHHHHHHHHHHHHHTT CS
         Arm   4 nkdavieaGavppLvrLLssedeevqeeAawALsNLaa 41 
                 +k+++ +a +vp+L+r+ + +d +v   Aa  L+NL+a
  EFC35931.1 276 QKILLSHA-IVPQLIRFANGKDKQVSSFAAKSLWNLSA 312
                 55555566.***************************96 PP

>> PBP_GOBP  PBP/GOBP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.3     1e-05     0.038       8      79 ..      26     113 ..      20     124 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1e-05
                 HHHHHHHHHHHH.............HHHHTS-TTHHHHHHT.T-SSS-HHHHHHHHHHHHHTTCBETTSSBBHHHHHHHHHHHTC..H CS
    PBP_GOBP   8 qkekikqlrkeC.............lkelgvsdesleklkk.gefpdddelkcfikCilkkfglmdedgklnedklveqlekmfs..e 79 
                 q+e+i++    C             +++l v++  +ek+++  e p+++++ c+++C++    + +++g+ +e +lv  l+   +   
  EFC35931.1  26 QLEQIRSKTVFCvynlivsddeggsIQKLLVKEGFVEKMVSiLENPNSENNECLANCLMSLSFVCEKKGQCSEIQLVRALKVVSNflT 113
                 667777777777555555555555556777777778888888778999999***********************99999988776653 PP

>> NTP_transf_7  Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.4   1.5e-05     0.054      82     168 ..      20     119 ..       2     184 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.5e-05
  NTP_transf_7  82 elseeeeldkvkeavlealldllPegvskekissltlkeaYvqklvkvsn.....dadr..WsLisls...nekgrnvelkfvdslrRqfef...sv 165
                   +  + ++l+++++  + ++ +l+ ++ +   i++l +ke +v+k+v + +     ++++    L+sls   ++kg++ e++ v  l+   +f   +v
    EFC35931.1  20 KQIDLTQLEQIRSKTVFCVYNLIVSDDEGGSIQKLLVKEGFVEKMVSILEnpnseNNEClaNCLMSLSfvcEKKGQCSEIQLVRALKVVSNFlthAV 116
                   444457899**************************************9652222122222246889876678999********99997666633356 PP

  NTP_transf_7 166 Dsf 168
                   Ds 
    EFC35931.1 117 DSI 119
                   665 PP

>> UNC45-central  Myosin-binding striated muscle assembly central
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.4    0.0083        30      75     115 ..      51      93 ..      49     124 .. 0.80
   2 ?   -0.6   0.1      0.31   1.1e+03     118     149 ..     143     173 ..     137     176 .. 0.82
   3 ?    9.4   0.1   0.00026      0.94      76     127 ..     276     327 ..     258     334 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0083
                    HHHHHTSTTHHHHHHHHHHS...S-HHHHHHHHHHHHTT--SS CS
  UNC45-central  75 asalflsegflesllelves..kkskkvqlaalellsaAcidk 115
                    +++l+ +egf+e +++ +e+  ++++++   +l  ls  c +k
     EFC35931.1  51 IQKLLVKEGFVEKMVSILENpnSENNECLANCLMSLSFVCEKK 93 
                    6789***************966666666666777777777666 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.31
                    SHHHHHHHHHHHHHHHH-SSHH..HHHHHHTT CS
  UNC45-central 118 rkaiaknyvewLeelvkssddeklvkalAavv 149
                    +++i +n v+  ++ + ++++  + ++l++vv
     EFC35931.1 143 HTFIMSNLVSAFKKFSSKNKTALE-HVLSSVV 173
                    689999999999998888888876.8888886 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00026
                    HHHHTSTTHHHHHHHHHHS.S-HHHHHHHHHHH.HTT--SSSSSHHHHHHHHH CS
  UNC45-central  76 salflsegflesllelveskkskkvqlaalell.saAcidkkcrkaiaknyve 127
                    ++++ls  +++ l+  ++  k+k+v++ a++ l + +++d kcr+ i+k++++
     EFC35931.1 276 QKILLSHAIVPQLIRFANG-KDKQVSSFAAKSLwNLSATDMKCREDIRKEGIN 327
                    5799999**********98.9999999888855499*************9985 PP

>> Inhibitor_I48  Peptidase inhibitor clitocypin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   4.5e-05      0.16      14      90 ..     189     267 ..     178     292 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.5e-05
  Inhibitor_I48  14 atGglyatgngvdkivavasqvpvlfdrqvW...kieavhGkkeaytsisihtlGgnwtskdgesiPetPvvtseesyef 90 
                    + Ggl    n + + +++asq p+ f+  +    k++  +   ea+   ++  l  +w+sk   +iP+  ++ s +   f
     EFC35931.1 189 SKGGLIILTNFLRDEISIASQKPSCFNMATSllvKLTNMRENIEAFRESGFVKLIAEWFSKSPCPIPQPNLE-SYNAALF 267
                    679999**********************998889*************99999***************75444.4444344 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       883  (0.0492498); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 1979.94
//
Query:       EFC35932.1  [L=176]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.073   13.8   0.8       0.13   13.0   0.8    1.4  1  DUF2626   Protein of unknown function (DUF2626)


Domain annotation for each model (and alignments):
>> DUF2626  Protein of unknown function (DUF2626)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.8   7.4e-06      0.13       4      36 ..       1      33 [.       1      44 [. 0.92

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 7.4e-06
     DUF2626  4 mfRvlgfwtgiiavlafvGdliemallflaqta 36
                mf    f+ +i+a+lafvG  + ++l fl+ t+
  EFC35932.1  1 MFNTKQFLVVILALLAFVGTCQAATLAFLSLTV 33
                888889***********************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       587  (0.0327403); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1071.86
//
Query:       EFC35933.1  [L=363]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.043   13.8   0.1      0.071   13.0   0.1    1.4  1  CYTH      CYTH domain


Domain annotation for each model (and alignments):
>> CYTH  CYTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1     4e-06     0.071      96     137 ..     268     320 ..     225     348 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 4e-06
                 HHHHHHHHHHTT.........-EEEEEEEEEEEEEEETTEEEEEEEETTT..T CS
        CYTH  96 aaeaaelldglg.........lepvasvkklRrkyklegvevalDavefl..e 137
                 ++e + ++d l          l pv+ v++ R +ykl++++v+lD ++    +
  EFC35933.1 268 RNELKLIIDELNngsseygeeLHPVQDVTIARKQYKLKDTLVELDVNKEEklF 320
                 444444444444445577777*************************9987444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (363 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2240.43
//
Query:       EFC35934.1  [L=202]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (202 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       476  (0.0265492); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.43
# Mc/sec: 1420.13
//
Query:       EFC35935.1  [L=141]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.043   13.2   1.1      0.063   12.6   1.1    1.3  1  7TM_GPCR_Srv  Serpentine type 7TM GPCR chemoreceptor Srv


Domain annotation for each model (and alignments):
>> 7TM_GPCR_Srv  Serpentine type 7TM GPCR chemoreceptor Srv
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   1.1   3.5e-06     0.063     169     232 ..       4      68 ..       1      82 [. 0.78

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.5e-06
  7TM_GPCR_Srv 169 livvvvtciiliiayvllfvvlrkkk.kkksqtkskslkrevrLaiqvlilvlaeliilifvils 232
                   + ++v++  + i++y ++ + +r  +  +++ +++k++++e +L++q l   l ++   ++vi++
    EFC35935.1   4 IAIEVASLALRIMIYWVTKKLFRDTTiVHNTPSAKKKREKERNLFKQLLFYALPFFLFGVWVIVY 68 
                   4566777777788888888888855544999999*************999999888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       566  (0.031569); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 966.59
//
Query:       EFC35936.1  [L=467]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-30  106.1   0.6    3.5e-30  105.3   0.6    1.5  1  Peptidase_M20  Peptidase family M20/M25/M40
    5.2e-14   52.1   0.1    1.7e-13   50.5   0.0    1.8  2  M20_dimer      Peptidase dimerisation domain


Domain annotation for each model (and alignments):
>> Peptidase_M20  Peptidase family M20/M25/M40
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  105.3   0.6   3.9e-34   3.5e-30       2     206 ..     134     462 ..     133     463 .. 0.81

  Alignments for each domain:
  == domain 1  score: 105.3 bits;  conditional E-value: 3.9e-34
                    EEEES-BSSTTCGGGSSS..TTSEEETTTEEESTTTTTTHHHHHHHHHHHHHHHHHTTT-..SSEEEEEEESTTSSTTTHH.HHHHH.......HH CS
                    xxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxx.xxxxx.......xx RF
  Peptidase_M20   2 lgsHlDvVpeeetdgwtt..pfslteedGklyGrGaddmkggvlaalealralkdegikp..kgtivllfqpdEEggrgGa.kalle.......gl 85 
                    +++H+DvVp ++ ++w    pfs+++++ ++yGrG++dmkgg+ a+l a++a++++   +  kg+i +  +++EE+g++G+  a+l        g+
     EFC35936.1 134 INGHIDVVPVGNPKAWYLenPFSGHINNSNIYGRGTTDMKGGLYAGLLAIEAVQRALNVTnmKGKIIVHSVVEEESGGAGTvSAVLRgyghadaGI 229
                    89*******888889*989********99**************************987776688***********865666655555333222222 PP

                    HTTTCESEEEEEEEESSSBTCHSTETEEEE.................................................................. CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................................................................. RF
  Peptidase_M20  86 eerekvdavfelhieepgileagklaigvv.................................................................. 115
                                   ep++         +                                                                   
     EFC35936.1 230 -------------FPEPSNFL-------IFpqqqgslwfritvhgksahggtrydgisaieksqivlnaikkleferthlirnvlkqklfenitip 305
                    .............23333333.......22222233333333558888888999999999999999999999999********************* PP

                    ..............................................................EEEEEEE.EEESHEEEC.CHHHHHHHHHHHHHHH CS
                    ..............................................................xxxxxxx.xxxxxxxxx.xxxxxxxxxxxxxxxx RF
  Peptidase_M20 116 ..............................................................kvevell.eggapvtln.dsplvkalaeaaeelf 147
                                                                                    ++e++  +  p  ++ ++++v  l ++ ++++
     EFC35936.1 306 vpinvgvikggewpssvpdftviegrfgiipnyetvedakkvlndlvfkiiveedpehfnayPSKLEFIgASWVPGYVPlEHEFVSQLTKSFSQVT 401
                    ****************************************************9999999988444443333333444446799************9 PP

                    TSCEEEEEESSSBHTHHHHTTT...EEEEEEESS.GGCTTSTTTEEEHHHHHHHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M20 148 gekvelivsgpggtdarffagi...ptvmifgpg.sglaHspnEyvdledlekgikvlarlle 206
                    g ++    s+  +tda++++++   p+v +fgpg   +aH+ nEy+ +e+++k+++v+a+++ 
     EFC35936.1 402 GQDPIIASSP-WATDAGYVNALgntPSV-VFGPGvTHMAHQTNEYIPIENIYKAAEVIANTIV 462
                    9777777777.********666635666.7****55***********************9985 PP

>> M20_dimer  Peptidase dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       1.1   9.6e+03      86     105 ..      47      65 ..      40      67 .. 0.68
   2 !   50.5   0.0   1.9e-17   1.7e-13       3     100 ..     242     351 ..     241     359 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.1
                 HHHHHHHHHHHHHHHHTSCC CS
   M20_dimer  86 pgedpeevleeieeilekea 105
                 p+++ ++v+ +i+++l++e+
  EFC35936.1  47 PEQE-HDVQIDIAKYLKEEL 65 
                 5444.458888999988875 PP

  == domain 2  score: 50.5 bits;  conditional E-value: 1.9e-17
                 B-EEEEEEEEEE-B-EEGG-TTTTB-HHHHHHHHHHCSCTTEEC................TCCTCCCCCEECCE-CCCCEESSEEEEEEEEEHHHH.HH CS
   M20_dimer   3 hkGlaggkitvkgkagHsgapgagaNAieklarllaeledeegdia...........eerslprttlnvtgiegGsaknvipdeaeakidiRllpg.ed 89 
                 + G+++++itv+gk++H+g + +g++Aiek   +l++++++e++ +            e+++ +  +nv++i+gG ++ ++pd +  +  + + p+ e+
  EFC35936.1 242 QQGSLWFRITVHGKSAHGGTRYDGISAIEKSQIVLNAIKKLEFERThlirnvlkqklFENITIPVPINVGVIKGGEWPSSVPDFTVIEGRFGIIPNyET 340
                 68******************************************************************************************7776155 PP

                 HHHHHHHHHHH CS
   M20_dimer  90 peevleeieei 100
                 +e++++ ++++
  EFC35936.1 341 VEDAKKVLNDL 351
                 77777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (467 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       600  (0.0334653); expected 358.6 (0.02)
Passed bias filter:                      514  (0.0286686); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 2846.51
//
Query:       EFC35937.1  [L=1397]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      2e-28   98.6   0.1    8.5e-28   96.6   0.1    2.2  1  SPA          Stabilization of polarity axis
    4.5e-07   30.0   1.5    4.5e-07   30.0   1.5    2.6  2  DENN         DENN (AEX-3) domain
      6e-06   26.8   0.0      6e-06   26.8   0.0    2.8  3  Afi1         Docking domain of Afi1 for Arf3 in vesicle traff
    0.00034   20.3   0.8    0.00092   18.9   0.2    2.1  2  ubiquitin    Ubiquitin family
      0.002   18.0   0.0     0.0049   16.7   0.0    1.7  1  UBA          UBA/TS-N domain
     0.0082   16.4   0.0      0.022   15.0   0.0    1.6  1  L_HMGIC_fpl  Lipoma HMGIC fusion partner-like protein
  ------ inclusion threshold ------
       0.48   10.5   1.6        1.2    9.1   1.6    1.6  1  DGF-1_C      Dispersed gene family protein 1 of Trypanosoma c
        3.2    8.1   6.4       0.73   10.2   0.8    2.8  3  DED          Death effector domain


Domain annotation for each model (and alignments):
>> SPA  Stabilization of polarity axis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   96.6   0.1   3.8e-31   8.5e-28       2     113 ..     471     586 ..     470     587 .. 0.94

  Alignments for each domain:
  == domain 1  score: 96.6 bits;  conditional E-value: 3.8e-31
         SPA   2 tsllkllekftpeiill.inalltskriivlstkasadevsefvLalsnlispagdvlrgfknnsfPyvdlse....ldalekvpgyIvGvtNPiF... 92 
                 tsl++l+++f+ e++l+ +nall++kri+v+++ a+   vs+++L+l +li+p    +++  n+++Pyv+lse    l+a++k+p+yI+G+tN++F   
  EFC35937.1 471 TSLVQLVQYFGLETMLVcWNALLLDKRIMVIGSPAKL--VSQICLTLPLLIYP----FQYNVNRVHPYVPLSEmddvLSATSKIPEYIIGTTNALFetq 563
                 689**************9*******************..*************9....66666777********9999999****************999 PP

         SPA  93 ..eeqeqlWDvlydldsgsvkls 113
                   ++++q+WDv+++++s++v+l+
  EFC35937.1 564 gkNQRTQWWDVCLSVNSRKVQLA 586
                 99999***************997 PP

>> DENN  DENN (AEX-3) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.0   1.5     2e-10   4.5e-07      64     171 ..     446     563 ..     357     577 .. 0.70
   2 ?   -2.3   0.4       1.6   3.6e+03      35     102 ..    1022    1086 ..    1000    1116 .. 0.62

  Alignments for each domain:
  == domain 1  score: 30.0 bits;  conditional E-value: 2e-10
        DENN  64 aveekillqrpedsel..Pl...edvdlkelfrcLsienilqlfeavLlErriillSeklarLtsvaealvallyPlkWq....hiyiPvlpaslldvl 153
                  ++++i+l+ p + +   P+   ++++l +l + +++e++l    a+Ll++ri+++ +  +++++++ +l  l+yP++++    h+y+P+  +   dvl
  EFC35937.1 446 PNTDTITLNIPRQIDPftPIaftHGTSLVQLVQYFGLETMLVCWNALLLDKRIMVIGSPAKLVSQICLTLPLLIYPFQYNvnrvHPYVPLSEMD--DVL 542
                 35566666666633333477777899*****************************************************766669999996543..333 PP

        DENN 154 ea..PtP.fiiGvessllele 171
                 +a   +P +iiG ++ l+e++
  EFC35937.1 543 SAtsKIPeYIIGTTNALFETQ 563
                 33113334*******999933 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.6
        DENN   35 eaplesfianlllevplPapgktlklvslaveekillqrpedselPledvdlkelfrcLsienilqlf 102 
                    +++++i+++++++    ++++ ++  ++  e  +  + + +e+  ++++++ l+  L++ n+++++
  EFC35937.1 1022 FTEMYHHISSIIMNIKNDLKKSSSVQ--QSEGEDSSDPQTHINEFHHHHMSVY-LLALLQSTNLINII 1086
                  46777888887777665554444444..4444555555555556634666666.78888888888765 PP

>> Afi1  Docking domain of Afi1 for Arf3 in vesicle trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.8   0.0   2.7e-09     6e-06       1      79 [.     233     315 ..     233     353 .. 0.65
   2 ?   -2.9   0.1       3.8   8.6e+03      95     101 ..    1046    1052 ..    1006    1080 .. 0.45
   3 ?   -2.8   0.4       3.6   8.1e+03      75      75 ..    1283    1283 ..    1227    1376 .. 0.57

  Alignments for each domain:
  == domain 1  score: 26.8 bits;  conditional E-value: 2.7e-09
        Afi1   1 yilvAeFdidkGpvikhqYPkaipg..detlseLAelmlPdqvhkrkqDitvFfLykdtsteeeeleeeek..knklekrkkk 79 
                 yil  eFd  kG  + h YP +     +  +s+L ++ lPd++h+ ++D t  ++ ++  + +     ++   +n+ +++ ++
  EFC35937.1 233 YILETEFDLLKGNTLSHVYPPERRTilNTFTSHLGDYCLPDGAHYFEEDATYLVIPSNVVSSSLYSYLKSGasSNNVSSVSNS 315
                 9*******************8844477777779********************999986654432221111112222222222 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.8
        Afi1   95 eddnedl 101 
                   +++e +
  EFC35937.1 1046 VQQSEGE 1052
                  1111111 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 3.6
        Afi1   75 k 75  
                   
  EFC35937.1 1283 I 1283
                  0 PP

>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.2   4.1e-07   0.00092       2      57 ..       6      62 ..       5      72 .. 0.78
   2 ?   -3.2   0.0       3.2   7.1e+03      50      64 ..    1234    1248 ..    1234    1248 .. 0.93

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 4.1e-07
                EEEE.TTSEEEEE.EEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGH CS
   ubiquitin  2 tvkt.ldgkkitl.eveesdtveelKekiaekegipaeqqrLiysGkvLedertleey 57
                +v+t ldg  + + +    +t+ +lK+ i    g +a+ q L+ +G +L+d++tl++ 
  EFC35937.1  6 KVRTvLDGI-VKVpKSTTLQTITDLKKGIYNLRGWEASTQHLYQNGTELKDDQTLSDS 62
                555544444.33335555689999*******************************996 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 3.2
                  TTSBHGGHTTSTTEE CS
   ubiquitin   50 dertleeygiqdgst 64  
                  d++++++y i+++st
  EFC35937.1 1234 DSQCVTQYFIEEDST 1248
                  899*********997 PP

>> UBA  UBA/TS-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.2e-06    0.0049       8      37 .]     196     225 ..     193     225 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.2e-06
                 HHHHTTS-HHHHHHHHHHTTTSHHHHHHHH CS
         UBA   8 rLveMGFdreevveALratgnNeErAveyL 37 
                   +e+GF++  +++AL   + ++E+Ave++
  EFC35937.1 196 MVMELGFSKRIAKKALILHNLDPEAAVEWI 225
                 579*************88888********8 PP

>> L_HMGIC_fpl  Lipoma HMGIC fusion partner-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   9.6e-06     0.022      62     137 ..     452     530 ..     420     534 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 9.6e-06
  L_HMGIC_fpl  62 flaipssawkaaavlvalgilllllvlll...slltlcrqsilkksvfkicallqlvaglllllglllyPlgWdseevr 137
                   l+ip ++  ++ +  + g+ l+ lv  +   ++l++ +  +l+k++  i + ++lv+ ++l+l ll+yP+ ++ ++v+
   EFC35937.1 452 TLNIPRQIDPFTPIAFTHGTSLVQLVQYFgleTMLVCWNALLLDKRIMVIGSPAKLVSQICLTLPLLIYPFQYNVNRVH 530
                  4555555544444445555555555544311156667778899*******************************99997 PP

>> DGF-1_C  Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   1.6   0.00056       1.2      29      70 ..     117     158 ..     113     166 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00056
     DGF-1_C  29 sdeelrklhdvtsssyasgttvassyrPPapplqplagdtrs 70 
                 sd+ ++ +h+ ts+  + +tt++++ rPP +p q  + + r+
  EFC35937.1 117 SDQLAQIMHEFTSTHPSGNTTTTTATRPPTQPVQNTTQQPRT 158
                 7888999*********99***************998887665 PP

>> DED  Death effector domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       4.2   9.5e+03      52      69 ..     408     424 ..     405     434 .. 0.71
   2 ?   -1.6   0.0       1.5   3.5e+03      52      73 ..     642     663 ..     638     666 .. 0.62
   3 ?   10.2   0.8   0.00032      0.73      31      77 ..     724     773 ..     713     777 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4.2
                 SSTTC-HHHHHHHCTTT- CS
         DED  52 lsednldlLkelLrrikr 69 
                 l+e++l+lL ++ ++i +
  EFC35937.1 408 LNETDLNLLNQVHDQI-N 424
                 7788888888887777.3 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.5
                 SSTTC-HHHHHHHCTTT-HHHH CS
         DED  52 lsednldlLkelLrrikrqdLl 73 
                  +  nl+++ elL + k  d++
  EFC35937.1 642 FKTHNLKFITELLTKGKLTDIV 663
                 5566777777777666555555 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00032
                 S--TT.S.HHHHHHHHHHCTSSSTTC-HHH...HHHHCTTT-HHHHHHCC CS
         DED  31 rklekiksglelfleLekrgllsednldlL...kelLrrikrqdLlkkie 77 
                 ++ ++++s l+l+++L++  ++++++l++L    ++L ++ ++dLl  ++
  EFC35937.1 724 SDDKQSESVLQLLQYLQDDRIIKKQKLKYLfdlDKMLCNVDQIDLLLSVS 773
                 44466799*******************99622267799999999997776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1056  (0.058899); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.92u 0.30s 00:00:01.22 Elapsed: 00:00:00.49
# Mc/sec: 8640.04
//
Query:       EFC35938.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.7e-26   92.5   2.5    2.6e-26   92.0   2.5    1.3  1  UPF0113_N  UPF0113 Pre-PUA domain
      2e-25   88.9   0.0      4e-25   87.9   0.0    1.5  1  UPF0113    UPF0113 PUA domain
    0.00076   19.4   0.0     0.0012   18.8   0.0    1.3  1  PUA        PUA domain


Domain annotation for each model (and alignments):
>> UPF0113_N  UPF0113 Pre-PUA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.0   2.5   4.4e-30   2.6e-26       1      81 [.       2      79 ..       2      80 .. 0.98

  Alignments for each domain:
  == domain 1  score: 92.0 bits;  conditional E-value: 4.4e-30
   UPF0113_N  1 RklseeetrivfekLtkyigdnvkelldrkdgtycfrlkkkrVyyvseellklaetikpenlisaGtclGkftktkkFrls 81
                R+l++ee+++ f+kLtkyig+nvk+l++   ++y fr +k++V+y+s+++l++ae+i  e l ++G+c+G+f+k+kkF+l+
  EFC35938.1  2 RPLTDEEMETFFDKLTKYIGKNVKQLIN---DKYSFRFHKDKVFYMSNQVLQFAENITFERLKTVGVCFGRFSKSKKFKLE 79
                99**************************...58**********************************************97 PP

>> UPF0113  UPF0113 PUA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.9   0.0   6.6e-29     4e-25       1      76 []      93     172 ..      93     172 .. 0.98

  Alignments for each domain:
  == domain 1  score: 87.9 bits;  conditional E-value: 6.6e-29
     UPF0113   1 kvvvkekaeklFLYGrdvlkesilkitesvkenqvvvVlnengeplGiGkirkdt...k.aspgkivvknlaDiGeYlRr 76 
                 kv+vk++ae +FLYG+++lk+++ ++te++++ q+vvV+n+n+ plG+G+++k+t   +  +p++iv+ ++aD+G YlR+
  EFC35938.1  93 KVWVKPQAELSFLYGNHILKTGLGRMTEDCPQYQGVVVMNMNDVPLGFGVAAKSTdecRyVKPTDIVCFHQADVGQYLRD 172
                 89********************************************************99*******************5 PP

>> PUA  PUA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0     2e-07    0.0012       2      63 ..      93     154 ..      92     159 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 2e-07
                 EEEE-HHHHHHHHTT-EEEGGGEEEEETT--TTSEEEEEETTSCEEEEEEESS-HHHHHHHC CS
         PUA   2 rvvvddgAvkallsgasLlapGvvevegdfeegdvVaivdedgelvavGlanysseelakik 63 
                 +v+v+ +A    l+g ++l  G+ ++ +d+ + + V++++ ++ +++ G+a  s++e + +k
  EFC35938.1  93 KVWVKPQAELSFLYGNHILKTGLGRMTEDCPQYQGVVVMNMNDVPLGFGVAAKSTDECRYVK 154
                 899999*************************************************9988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       608  (0.0339115); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1130.67
//
Query:       EFC35939.1  [L=149]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1468  (0.0818785); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.25s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 983.86
//
Query:       EFC35940.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.9e-08   33.8   0.0    7.6e-08   33.2   0.0    1.3  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
      0.067   13.9   0.1       0.18   12.5   0.1    1.8  1  2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
      0.071   12.1   0.0      0.098   11.6   0.0    1.1  1  PAD             Protein-arginine deiminase (PAD)


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.2   0.0   1.3e-11   7.6e-08       3      81 ..     113     200 ..     111     212 .. 0.86

  Alignments for each domain:
  == domain 1  score: 33.2 bits;  conditional E-value: 1.3e-11
                     EEEE-TT-EEEEE-SS--............--TT.-.EEEEEEEEE....ET-B--EEE...........---TT-EEEEE-..B-TEEE-- CS
  2OG-FeII_Oxy_3   3 vlrygegqeykpHvDnfe............keegsgqrrltvllyLnekeseeGGelelyekdk.eavkikpkkgrlvlFesdellpHevlp 81 
                     +++y +g+++ pH+D +             k +  ++  +tvllyLn  + e+GGe  + +++    +++kp++g++++F  ++   He++ 
      EFC35940.1 113 FYKYAAGEYFAPHYDGCFqrptlnveingkKMKVVERSFITVLLYLN--DVESGGETNFLNSRCeIIHSVKPQAGQVLMFVHSNY--HEGSV 200
                     789999*********9889********998666667899*******8..5699***9998777788999************9777..99875 PP

>> 2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1     3e-05      0.18      22      73 ..     149     197 ..     111     212 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3e-05
  2OG-FeII_Oxy_4  22 eRrvayilyleeeWkeddGGaLllsddegdvtksivPkwnqlvlFevkeshs 73 
                     + +++++lyl+   + + GG+ ++ ++++++ +s+ P+ +q+ +F  ++ h+
      EFC35940.1 149 RSFITVLLYLN---DVESGGETNFLNSRCEIIHSVKPQAGQVLMFVHSNYHE 197
                     44566677776...5799***************************7665564 PP

>> PAD  Protein-arginine deiminase (PAD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   1.6e-05     0.098     212     279 ..      26      95 ..      18      98 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.6e-05
                 EEEHHHHHHHHHHCCCTTTTT-EETTTS......TTS--EECHHHHC-CCHHHHHHHHHHHHHHHHHHHH CS
         PAD 212 laspsaclellrekkkeghgdvklfsglsk..aekevekvtinelLadeslikenayvqkkidknreilk 279
                 l s+++c +ll+e ++ g+g++++ +g+++  ++k+v++ + + + +++      ++++k++ +n++ lk
  EFC35940.1  26 LFSTEECSKLLKESEEIGYGEAPISTGPTSstIMKDVRNNSRAMIDKKQYSDMLYKKLEKYLPQNVSSLK 95 
                 679************************9876544444444433333333333334455666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       405  (0.0225891); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1384.82
//
Query:       EFC35941.1  [L=307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    8.7e-25   84.6   6.1     0.0014   18.5   0.1    8.4  8  LRR_6       Leucine Rich repeat
    1.1e-14   53.9   8.3    2.1e-07   30.6   0.9    4.3  4  LRR_8       Leucine rich repeat
      2e-14   53.5   8.9     0.0033   17.8   1.0    5.2  4  LRR_4       Leucine Rich repeats (2 copies)
    0.00036   20.3   0.1     0.0028   17.5   0.0    2.2  2  FTH         FTH domain
     0.0007   19.8   4.7         40    5.3   0.1    6.5  7  LRR_1       Leucine Rich Repeat
    0.00081   19.2   0.3     0.0014   18.4   0.3    1.3  1  F-box-like  F-box-like
    0.00098   18.9   0.8     0.0021   17.9   0.8    1.5  1  F-box       F-box domain
     0.0032   17.7   0.2        1.6    9.0   0.1    3.4  4  Phage_CI_C  Bacteriophage CI repressor C-terminal domain
  ------ inclusion threshold ------
       0.02   14.6   0.8       0.82    9.4   0.0    3.2  4  RecO_N_2    RecO N terminal
       0.11   12.4   1.3         48    4.0   0.0    4.3  5  ApoB100_C   Apolipoprotein B100 C terminal


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0      0.01        19      12      24 .]     115     127 ..     115     127 .. 0.91
   2 ?    5.5   0.0     0.012        22       5      24 .]     132     151 ..     128     151 .. 0.89
   3 !   18.5   0.1   7.7e-07    0.0014       4      24 .]     155     175 ..     152     175 .. 0.91
   4 ?    5.4   0.0     0.013        23       5      24 .]     180     199 ..     177     199 .. 0.87
   5 !   16.5   0.0   3.5e-06    0.0063       3      24 .]     202     223 ..     200     223 .. 0.91
   6 !   16.3   0.0   3.9e-06    0.0069       5      23 ..     228     246 ..     225     247 .. 0.92
   7 ?    3.5   0.0     0.053        94       3      24 .]     250     271 ..     248     271 .. 0.89
   8 !    7.9   0.0     0.002       3.6       5      19 ..     276     290 ..     273     295 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.01
       LRR_6  12 gNdIgDeGaeaLa 24 
                 +NdIg eGa+ ++
  EFC35941.1 115 FNDIGVEGAKHIS 127
                 6*********986 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.012
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L +sgN +g eGa+ ++
  EFC35941.1 132 LTFLGVSGNFVGVEGAKYIS 151
                 999*************9875 PP

  == domain 3  score: 18.5 bits;  conditional E-value: 7.7e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt Ld+ +N+IgDeGa+ ++
  EFC35941.1 155 QLTNLDICFNNIGDEGAKHIS 175
                 59****************986 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.013
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ L +  N Ig eGa+ ++
  EFC35941.1 180 LKNLKIGNNYIGVEGAKYIS 199
                 8889999999******9875 PP

  == domain 5  score: 16.5 bits;  conditional E-value: 3.5e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  hLt+L++s+N++  eG++ ++
  EFC35941.1 202 KHLTKLSISYNNVRVEGVKYIS 223
                 6*****************9875 PP

  == domain 6  score: 16.3 bits;  conditional E-value: 3.9e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++  N IgDeGa+ +
  EFC35941.1 228 LTDLNIGENVIGDEGAKHI 246
                 9***************987 PP

  == domain 7  score: 3.5 bits;  conditional E-value: 0.053
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt L++sg +I+ +Ga+ ++
  EFC35941.1 250 NQLTRLSISGVEISEAGAKYIC 271
                 579**************99987 PP

  == domain 8  score: 7.9 bits;  conditional E-value: 0.002
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt L+++ N+Ig  G
  EFC35941.1 276 LTQLNIKNNNIGKIG 290
                 9**********9766 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.028        50      41      59 ..     122     140 ..     100     141 .. 0.78
   2 !   30.6   0.9   1.2e-10   2.1e-07       2      60 ..     155     213 ..     154     214 .. 0.98
   3 !   24.2   0.2   1.2e-08   2.1e-05       2      58 ..     203     259 ..     202     262 .. 0.97
   4 !   13.2   0.4   3.1e-05     0.055       2      41 ..     251     290 ..     250     301 .. 0.91

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.028
                 GGGGGTT--S-.EEE--SS CS
       LRR_8  41 spgafsgLpsLrsLdLsgN 59 
                  ++ +s+L++L++L +sgN
  EFC35941.1 122 GAKHISQLKQLTFLGVSGN 140
                 5677899**********99 PP

  == domain 2  score: 30.6 bits;  conditional E-value: 1.2e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+Ld+++N++ + + +  + l++Lk L+++nN + +  ++ +s+L++L++L +s+N+
  EFC35941.1 155 QLTNLDICFNNIGDEGAKHISELKQLKNLKIGNNYIGVEGAKYISQLKHLTKLSISYNN 213
                 7*********************************************************8 PP

  == domain 3  score: 24.2 bits;  conditional E-value: 1.2e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +Lt+L++s N+  + + +  + +++L+ L++++N +    ++ +  L++L+ L +sg
  EFC35941.1 203 HLTKLSISYNNVRVEGVKYISEMKQLTDLNIGENVIGDEGAKHIKKLNQLTRLSISG 259
                 8*****************************************************997 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 3.1e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGG CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttls 41 
                 +Lt+L++s   +++ + +    +++L+ L+++nN++  + 
  EFC35941.1 251 QLTRLSISGVEISEAGAKYICEMKQLTQLNIKNNNIGKIG 290
                 7999*******************************98885 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.021        38       2      33 ..     107     140 ..     106     154 .. 0.80
   2 !   17.8   1.0   1.9e-06    0.0033       1      36 [.     154     190 ..     154     194 .. 0.89
   3 !   17.6   0.1   2.1e-06    0.0038       1      34 [.     202     240 ..     202     264 .. 0.70
   4 !   14.7   0.4   1.8e-05     0.032       3      39 ..     252     289 ..     250     304 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.021
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 +L +L    N +   +   +++l++L+ L +sgN
  EFC35941.1 107 RLSHLRACFNDIGVEGAkhISQLKQLTFLGVSGN 140
                 6788888888999655576667999999999999 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 1.9e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++Ld+  N++ d +   ++ l++Lk L + gNn+i
  EFC35941.1 154 KQLTNLDICFNNIGDEGAkhISELKQLKNLKI-GNNYI 190
                 58*************99987555*********.99999 PP

  == domain 3  score: 17.6 bits;  conditional E-value: 2.1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S...- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN...n 34 
                 ++L++L++s N+++  +   ++ +++L+ L++ +N    
  EFC35941.1 202 KHLTKLSISYNNVRVEGVkyISEMKQLTDLNIGENvigD 240
                 68*******66666444443666*********7774440 PP

  == domain 4  score: 14.7 bits;  conditional E-value: 1.8e-05
                 --EEE--SS---E-S-...HHH-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdipl...leklpnLkeLdLsgNnlitdl 39 
                 L+ L++s+  +++ +    +e +++L++L++  Nn+i+++
  EFC35941.1 252 LTRLSISGVEISEAGAkyiCE-MKQLTQLNI-KNNNIGKI 289
                 788888886777766665444.999999999.88889888 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   1.6e-06    0.0028      42     112 ..     154     225 ..     124     235 .. 0.92
   2 ?    0.1   0.0      0.35   6.2e+02      83     112 ..     244     273 ..     226     297 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.6e-06
         FTH  42 gtLeeIel.sseeeeeefeelveleQWKnAkklkiessklssfpiehlfhFeefeikldkfsvedaikirdi 112
                 ++L ++++ +++   e  + + el+Q Kn k  + +     ++ i +l h+++++i+ +++ ve +++i ++
  EFC35941.1 154 KQLTNLDIcFNNIGDEGAKHISELKQLKNLKIGNNYIGVEGAKYISQLKHLTKLSISYNNVRVEGVKYISEM 225
                 57999999888889999*****************9999999999**********************999775 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.35
         FTH  83 fpiehlfhFeefeikldkfsvedaikirdi 112
                 ++i++l ++++++i+  ++s+  a++i ++
  EFC35941.1 244 KHIKKLNQLTRLSISGVEISEAGAKYICEM 273
                 378888888888888888888888888665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       4.7   8.4e+03       2      21 ..     108     127 ..     107     129 .. 0.68
   2 ?   -1.9   0.0       5.2   9.4e+03       2      16 ..     132     146 ..     131     153 .. 0.68
   3 ?    5.3   0.1     0.023        40       2      23 .]     156     177 ..     155     177 .. 0.88
   4 ?    2.8   0.1      0.15   2.8e+02       1       1 [.     203     203 ..     179     224 .. 0.59
   5 ?    2.1   0.0      0.25   4.5e+02       2      23 .]     228     249 ..     227     249 .. 0.90
   6 ?   -3.0   0.0        10   1.8e+04       2       9 ..     252     259 ..     251     260 .. 0.81
   7 ?    3.7   0.1     0.075   1.3e+02       2      19 ..     276     293 ..     275     299 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 4.7
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L hL  + n ++  ++ +++
  EFC35941.1 108 LSHLRACFNDIGVEGAKHIS 127
                 67787788887777666665 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 5.2
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L+ L +s+n+ +  +
  EFC35941.1 132 LTFLGVSGNFVGVEG 146
                 778889999975555 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.023
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ Ld++ n++++ ++ +++ L
  EFC35941.1 156 LTNLDICFNNIGDEGAKHISEL 177
                 899********99999998765 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.15
       LRR_1   1 n 1  
                 +
  EFC35941.1 203 H 203
                 2 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.25
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ L+++ n +++ ++ ++++L
  EFC35941.1 228 LTDLNIGENVIGDEGAKHIKKL 249
                 889**********999999987 PP

  == domain 6  score: -3.0 bits;  conditional E-value: 10
       LRR_1   2 LrhLdLsn 9  
                 L++L +s+
  EFC35941.1 252 LTRLSISG 259
                 89999986 PP

  == domain 7  score: 3.7 bits;  conditional E-value: 0.075
       LRR_1   2 LrhLdLsnnpllglppns 19 
                 L+ L++ nn+++ +++++
  EFC35941.1 276 LTQLNIKNNNIGKIGKEY 293
                 899******997766655 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.3   8.1e-07    0.0014       6      38 ..      31      65 ..      31      71 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 8.1e-07
  F-box-like  6 dEiLlqIFsyL.pps.dLlrlalVCrrWrrvaldt 38
                d+iL +I+s+  +++   l++alV+++W +v+l  
  EFC35941.1 31 DDILGEILSFYdDFKfIVLNCALVSKQWLNVILER 65
                689******87677777**************9765 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.8   1.2e-06    0.0021       8      47 ..      31      72 ..      28      73 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 1.2e-06
                HHHHHHHHHTS-HHH....HHHHCTT-HHHHHHHTTHHHHHHHH CS
       F-box  8 sevlrhILerLplsd....llalrrVSkgwrilidsdrlwcksi 47
                +++l +IL++ +  d    +l++++VSk w ++i + ++ c ++
  EFC35941.1 31 DDILGEILSFYD--DfkfiVLNCALVSKQWLNVILERSRLCFRC 72
                678888888844..466******************999999887 PP

>> Phage_CI_C  Bacteriophage CI repressor C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0         3   5.4e+03      59      73 ..     118     132 ..     117     140 .. 0.86
   2 ?   -0.6   0.0      0.92   1.6e+03      59      74 ..     142     157 ..     137     177 .. 0.80
   3 ?    4.4   0.0     0.025        45      48      88 ..     179     217 ..     164     225 .. 0.79
   4 !    9.0   0.1   0.00091       1.6      47      96 ..     226     278 ..     213     281 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3
  Phage_CI_C  59 vdieGrlsirelari 73 
                 +++eG++ i +l+++
  EFC35941.1 118 IGVEGAKHISQLKQL 132
                 6799***99999876 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.92
  Phage_CI_C  59 vdieGrlsirelariP 74 
                 v++eG++ i +l+++ 
  EFC35941.1 142 VGVEGAKYISQLKQLT 157
                 899******9999885 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.025
  Phage_CI_C  48 keadvsdGkwLvdieGrlsirelariPvkklrvsgdevsfe 88 
                 + ++++ G+  +++eG++ i +l+++   kl +s ++v +e
  EFC35941.1 179 QLKNLKIGNNYIGVEGAKYISQLKHLT--KLSISYNNVRVE 217
                 56788889999***********99986..888887777665 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00091
  Phage_CI_C  47 kkeadvsdGkwLvdieGrlsire...lariPvkklrvsgdevsfecklddikv 96 
                 k+ +d++ G+  ++ eG++ i++   l+r+ ++ +++s++++++ c++++++ 
  EFC35941.1 226 KQLTDLNIGENVIGDEGAKHIKKlnqLTRLSISGVEISEAGAKYICEMKQLTQ 278
                 456788889999999**99987522268999***************9998875 PP

>> RecO_N_2  RecO N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.8   6.9e+03      47      62 ..      98     113 ..      94     116 .. 0.70
   2 ?    9.4   0.0   0.00046      0.82      32      70 ..     120     163 ..     110     164 .. 0.91
   3 ?    2.0   0.1     0.094   1.7e+02      46      70 ..     187     211 ..     169     212 .. 0.69
   4 ?   -2.8   0.0       2.9   5.2e+03      54      67 ..     243     256 ..     240     258 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.8
    RecO_N_2  47 dfeleengkfLprLra 62 
                 d+++    k L++Lra
  EFC35941.1  98 DYQILGLMKRLSHLRA 113
                 6777777777788776 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00046
    RecO_N_2  32 fyGarh.....sliqlgtkidfeleengkfLprLravlhlgfkw 70 
                 + Ga+h      l+ lg  ++f+  e +k++++L++ + l+  +
  EFC35941.1 120 VEGAKHisqlkQLTFLGVSGNFVGVEGAKYISQLKQLTNLDICF 163
                 579999999999999***********************998765 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.094
    RecO_N_2  46 idfeleengkfLprLravlhlgfkw 70 
                  ++   e +k++++L++ ++l  ++
  EFC35941.1 187 NNYIGVEGAKYISQLKHLTKLSISY 211
                 46778889999********998877 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 2.9
    RecO_N_2  54 gkfLprLravlhlg 67 
                 +k +++L++ + l 
  EFC35941.1 243 AKHIKKLNQLTRLS 256
                 56788888888775 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.82   1.5e+03      19      34 ..     172     187 ..     163     208 .. 0.67
   2 ?   -2.0   0.0         2   3.5e+03      19      32 ..     196     209 ..     194     214 .. 0.73
   3 ?    4.0   0.0     0.027        48      19      32 ..     220     233 ..     205     236 .. 0.89
   4 ?    0.7   0.0      0.29   5.2e+02      14      34 ..     263     283 ..     258     286 .. 0.83
   5 ?    1.9   0.0      0.12   2.2e+02      18      32 ..     292     306 ..     290     307 .] 0.85

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.82
   ApoB100_C  19 kliaeskrLiDLsIek 34 
                 k i+e k+L  L I +
  EFC35941.1 172 KHISELKQLKNLKIGN 187
                 6688888888888854 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k i++ k L  LsI
  EFC35941.1 196 KYISQLKHLTKLSI 209
                 56777777777777 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.027
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k i+e k+L DL I
  EFC35941.1 220 KYISEMKQLTDLNI 233
                 88**********99 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.29
   ApoB100_C  14 sdyyEkliaeskrLiDLsIek 34 
                 s+   k i e k+L  L I++
  EFC35941.1 263 SEAGAKYICEMKQLTQLNIKN 283
                 6666799*********99987 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.12
   ApoB100_C  18 EkliaeskrLiDLsI 32 
                 E + +e k LiDL +
  EFC35941.1 292 EYICTELKYLIDLEV 306
                 677899*******76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1794.10
//
Query:       EFC35942.1  [L=184]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (184 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       547  (0.0305092); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.37u 0.23s 00:00:00.60 Elapsed: 00:00:00.40
# Mc/sec: 1368.83
//
Query:       EFC35943.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0047   17.4   2.3     0.0066   17.0   2.3    1.3  1  PIN_12    PIN domain


Domain annotation for each model (and alignments):
>> PIN_12  PIN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   2.3   3.7e-07    0.0066      12      98 ..       7      94 ..       3     122 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3.7e-07
      PIN_12 12 ffrlseeealkklleliesgkiklivpdivldEflknrekkieeskkle.kalkslsklksakkklnekkkllslkeikkkieekvee 98
                 + l++ + +k l + +  ++ +  v ++vl+E  k+++k+i+++++++ ++lk+++  +s+++kl  +  + +  +  +k+++ +++
  EFC35943.1  7 EYSLEYTKLMKVLINIVLVNREYCKVAKQVLNESTKKYKKDISSIESAIeSKLKEYESTQSNQDKLLMLRLSSYTIQSISKLDSDLDA 94
                566666667777777788888888899****************995555577777777777777777777777777777777776554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2076  (0.11579); expected 358.6 (0.02)
Passed bias filter:                      664  (0.037035); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1024.71
//
Query:       EFC35944.1  [L=143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.23   10.0   3.9       0.24    9.9   3.9    1.1  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   3.9   1.3e-05      0.24     316     391 ..      10      86 ..       3     132 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 1.3e-05
    Macoilin 316 vkskssssssssnknskkasagsagssnssskkhsessksvtsssssknskkqklpaGkssa.alkdaaenslpnnq 391
                 +++++ss ss+++k+   + + +   s+ss+++ +++++  +sssss++ kk  l   +++  +++d   +++p + 
  EFC35944.1  10 SSNNNSSPSSDTQKSFPATGGRTLRVSSSSTNEDNSTDRIGASSSSSTDVKKAPLNNNNNNIiIKRDDGMENIPREF 86 
                 45666677777778888777777777888888888887778888888888887776555555656665555566554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      236  (0.013163); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.32s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 902.98
//
Query:       EFC35945.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.8e-12   46.8   0.0    4.1e-12   46.3   0.0    1.3  1  NUDIX           NUDIX domain
  ------ inclusion threshold ------
      0.023   14.0   0.2      0.037   13.3   0.2    1.2  1  Glyco_hydro_97  Glycoside hydrolase 97
      0.073   12.6   0.6        0.1   12.2   0.1    1.5  2  NUDIX_2         Nucleotide hydrolase


Domain annotation for each model (and alignments):
>> NUDIX  NUDIX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.3   0.0   6.9e-16   4.1e-12       7     114 ..      53     164 ..      47     179 .. 0.75

  Alignments for each domain:
  == domain 1  score: 46.3 bits;  conditional E-value: 6.9e-16
                 EEEEEETTSE...EEEEEESSSSTTTEESSEEECBTTSHHHHHHHHHHHHHHSEEEEEEEEEEEEEEEEEEEEEEEE......EEEEEEEEEEEECSGC CS
       NUDIX   7 gvvllnekge...vLlvrrskkpfpgWelPgGkvepgEtpeeAArREleEEtGleaellellgrlhylapydgpygd......eheilyvfleevegel 96 
                 g++l+++ +    +Ll+++s    +  +lP+G++epgEt+ e+A RE++EEt ++ +l+ ++ ++  + +y  + ++      ++  +y+ ++++  +l
  EFC35945.1  53 GILLFRKLTSkydFLLMKHS----RRLDLPKGRMEPGETFIETAKREFNEETSIPLDLIGIHPDFLFEEKYAYFSKSksiqvgKTLKMYIAFAKDSTKL 147
                 66666666555669999999....4478*************************9889996555555555555555544455876666688887777777 PP

                 SSTSTTTEEEEEEEEHHH CS
       NUDIX  97 epndenevsevrwvplee 114
                 + +   e+ +++w  ++e
  EFC35945.1 148 NIK-LTEHGDCKWTQFKE 164
                 776.78889999998877 PP

>> Glyco_hydro_97  Glycoside hydrolase 97
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.2   6.2e-06     0.037      35      97 ..     132     194 ..     116     204 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 6.2e-06
  Glyco_hydro_97  35 etvkryiDfAae.ngleyvlvegwdegWeekkkkekefdftkpypdfdleelvaYakekgvgve 97 
                     +t k yi fA++  +l+  l e  d +W++ +k+++ + + +++ d  l+++ +Y +ekg ++e
      EFC35945.1 132 KTLKMYIAFAKDsTKLNIKLTEHGDCKWTQ-FKEKEAMTIQNNTIDPLLKSIQDYMNEKGLDLE 194
                     7899******972578888999******96.66677888899999999************5554 PP

>> NUDIX_2  Nucleotide hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   1.7e-05       0.1      15      96 ..      21     101 ..      12     145 .. 0.69
   2 ?   -2.9   0.0      0.69   4.1e+03      15      40 ..     164     189 ..     158     195 .. 0.49

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.7e-05
     NUDIX_2  15 kkeklkekd..ksveeklkrlkesyekeglrrtveavllvhrhelphvLlLqielqefkLpggklksgedeiegLkrkLakkls 96 
                 k +++++++   + +e+l+++ + +e+e +    +++ll  +    + +lL +++  + Lp g++++ge+ ie+ kr +++  s
  EFC35945.1  21 KTNSKENRHvfLTEKEQLEQYGRIVEHEEI---SCGILLFRKLTSKYDFLLMKHSRRLDLPKGRMEPGETFIETAKREFNEETS 101
                 444444444224445555555555555544...68******************************************9998876 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.69
     NUDIX_2  15 kkeklkekdksveeklkrlkesyeke 40 
                 +ke+ + ++++++  lk  ++  +++
  EFC35945.1 164 EKEAMTIQNNTIDPLLKSIQDYMNEK 189
                 44444444444444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1044  (0.0582297); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1284.09
//
Query:       EFC35946.1  [L=189]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       363  (0.0202465); expected 358.6 (0.02)
Passed bias filter:                      263  (0.014669); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1271.30
//
Query:       EFC35947.1  [L=477]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-10   39.3   0.0    1.2e-09   38.4   0.0    1.4  1  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.4   0.0   6.6e-14   1.2e-09      11     108 ..     292     402 ..     284     405 .. 0.83

  Alignments for each domain:
  == domain 1  score: 38.4 bits;  conditional E-value: 6.6e-14
                 S-EEEEETT....TEEEEE-HHHHHHH-HHHHHHHTST........TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHHHHHT- CS
         BTB  11 cDvtlvvgd....gkefkahkavLaarSpyFkalftsk........eieessvseielddvepeafealLefiYtgeleit.seenleelLaaadllqi 96 
                 +D+++++ d     k++++hk vL+++S+++++ f  +        + +  +v+++     +p+++e ++e++Y    +i+ s++++  l++aa++++i
  EFC35947.1 292 SDAVVKIPDslggVKTIYCHKTVLSSASEMLEVNFGPNwsneededGRAIINVEHLIEVASDPSVMEFIIEYAYGIFAPIKvSSKQVIPLIKAAHFYRI 390
                 5666666666666789**********************987655543344445577777889*************999999999*************** PP

                 HHHHHHHHHHHH CS
         BTB  97 prlkkaceeflk 108
                 + l ++c +++ 
  EFC35947.1 391 QGLLDECLYLCV 402
                 *******88775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (477 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       905  (0.0504769); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 2804.41
//
Query:       EFC35948.1  [L=267]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-19   70.0   0.0    2.6e-19   69.6   0.0    1.2  1  ThiF           ThiF family
    3.2e-05   24.0   0.4    0.00012   22.2   0.2    2.1  2  E1_FCCH        Ubiquitin-activating enzyme E1 FCCH domain
    4.7e-05   23.8   0.0    7.8e-05   23.1   0.0    1.3  1  NAD_binding_7  Putative NAD(P)-binding
    6.5e-05   23.2   0.0    0.00014   22.1   0.0    1.5  1  TrkA_N         TrkA-N domain
     0.0014   18.7   0.1     0.0089   16.1   0.0    2.1  2  Shikimate_DH   Shikimate / quinate 5-dehydrogenase
  ------ inclusion threshold ------
      0.021   14.8   0.1      0.028   14.4   0.1    1.3  1  KR             KR domain


Domain annotation for each model (and alignments):
>> ThiF  ThiF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.6   0.0   8.6e-23   2.6e-19      11     149 ..      21     164 ..       6     198 .. 0.87

  Alignments for each domain:
  == domain 1  score: 69.6 bits;  conditional E-value: 8.6e-23
                 HHHHHHHTSEEEEE--SHHHHHHHHHHHHHTTTEEEEEESSB--GGGGGTBTTS.....-GGGTTSBHHHHHHHHHHHT-TTSEEEEEES-CCG.CCS- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx RF
        ThiF  11 dgqekLrdskvllvGaGglGsellknLalsGvgkltlvDnDkielsNlnRqflf.....reediGkpKaevaaealqeinpdveveavteritd.etvl 103
                 d     ++++vl+ G+GglG e++knL   G+++ltl+D   +++++l   + +     +ee iG+++ae a   l+ +np ++++   +++++     
  EFC35948.1  21 DKITTFNKCRVLVCGMGGLGLEVAKNLLQNGIEQLTLMDSKMVSYEDLADFYSIvadskEEEVIGRNRAERAMIVLNGLNPFAKINVKDGQVDSlAG-D 118
                 666677889****************************************998763333345667****************************99665.5 PP

                 HHHHTT-SEEEEESSSHHHHHHHHHHHHHHT-EEEEEEEETTEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF 104 eellesvDlVvdalDniearrlvnracvkkgiplieagtlgfegqv 149
                  ++l+++D+V+ +  ++++   ++++c+ + i+++ +++ g+++ +
  EFC35948.1 119 VQFLKEFDFVICTEHSLSSLIDLAQICHDNNIKFVASDMKGLSSLI 164
                 69***********************************999988755 PP

>> E1_FCCH  Ubiquitin-activating enzyme E1 FCCH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.3   3.9e+03      41      52 ..     119     130 ..      92     137 .. 0.53
   2 !   22.2   0.2   3.9e-08   0.00012      13      61 ..     208     257 ..     192     267 .] 0.81

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.3
                 -EE-SSSEEE-- CS
     E1_FCCH  41 ikvlgpytFeIg 52 
                 ++ l+++ F I+
  EFC35948.1 119 VQFLKEFDFVIC 130
                 333355555555 PP

  == domain 2  score: 22.2 bits;  conditional E-value: 3.9e-08
                 -S---TT-EEEEES-BT-CCGGGS--EE-EE-SSSEEE--.--TTS-SEE CS
     E1_FCCH  13 rhgledgDyVtFseveGmtelNgkeprkikvlgpytFeIg.dtsnfspYk 61 
                 + g++  + + F++v+GmtelN+++ ++ik +  +   ++ d +nf++++
  EFC35948.1 208 EEGMNVHQNIVFRNVRGMTELNEHKAVRIKSKIGNRVVVDlDSTNFGKFE 257
                 45677778899*************99****99888888888888988886 PP

>> NAD_binding_7  Putative NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.0   2.6e-08   7.8e-05       4     102 ..      25     165 ..      23     166 .. 0.70

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 2.6e-08
  NAD_binding_7   4 dlkgkkvlvvGgGevAarkvrklleag.akvtvvapev..keele.............elvklaeee...................lekd...... 58 
                     +++ +vlv G G ++++ +++ll++g  ++t+++ ++   e  +             e       e                   +         
     EFC35948.1  25 TFNKCRVLVCGMGGLGLEVAKNLLQNGiEQLTLMDSKMvsYE--DladfysivadskeE-------EvigrnraeramivlnglnpF--Akinvkd 109
                    57889**********************889******985422..233333333333220.......233333333444444444441..0444444 PP

  NAD_binding_7  59 ............legadlviaatddrelneriaeaakarrilvnvadkpelcdfif 102
                                l+++d+vi++    +    +a+ +++++i + ++d + l++ if
     EFC35948.1 110 gqvdslagdvqfLKEFDFVICTEHSLSSLIDLAQICHDNNIKFVASDMKGLSSLIF 165
                    555566666888999*******999999999******************9999987 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   0.0   4.6e-08   0.00014       1      67 [.      31      96 ..      31     105 .. 0.90

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 4.6e-08
                EEEES-SHHHHHHHHHHHHTT.EEEEEEESSHHHHHHHHHTTSEEEES-TTSHHHHHHTTGGGESEEE CS
      TrkA_N  1 iiiiGlGrvGrslaeeLsegg.kdvvvidkdeerveelreeglevvvgdatdeevLeeagiekadavi 67
                ++++G+G +G ++a++L ++g ++ ++ d++    e l+   +  +v+d  +eev+ +  +e+a +v+
  EFC35948.1 31 VLVCGMGGLGLEVAKNLLQNGiEQLTLMDSKMVSYEDLA--DFYSIVADSKEEEVIGRNRAERAMIVL 96
                68*****************77789******999999987..6779***************99998886 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0     3e-06    0.0089       6      56 ..      22      72 ..      19      82 .. 0.88
   2 ?   -0.3   0.0      0.35     1e+03      65      91 ..     114     140 ..      82     157 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 3e-06
                  HHS..TT-EEEEES-SHHHHHHHHHHHCCT-CEEEEEESSHHHHHHHHHHH CS
  Shikimate_DH  6 kleslkekkvlliGaGemaelvakhLlakgvkkvvvaNRtlerakelaeel 56
                  k+ ++++++vl+ G G ++ +vak+Ll++g+++++ +   +   ++la+ +
    EFC35948.1 22 KITTFNKCRVLVCGMGGLGLEVAKNLLQNGIEQLTLMDSKMVSYEDLADFY 72
                  566799******************************999888888888755 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.35
                   EGCGHHHHHHT-SEEEE-SSSSS-SB- CS
  Shikimate_DH  65 kleelkellaeadvvisataseepile 91 
                   +l    + l+e+d vi+   s + +++
    EFC35948.1 114 SLAGDVQFLKEFDFVICTEHSLSSLID 140
                   455555788999999988777766665 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.1   9.2e-06     0.028       5      35 ..      32      62 ..      29     156 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 9.2e-06
                EETTTSHHHHHHHHHHHHHHS-EEEEE-SS. CS
          KR  5 itGGlGgLGlelarwlaekgarhlvllsRsa 35
                ++ G+GgLGle+a+ l+++g ++l l+  + 
  EFC35948.1 32 LVCGMGGLGLEVAKNLLQNGIEQLTLMDSKM 62
                4557*********************997664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       609  (0.0339673); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1724.13
//
Query:       EFC35949.1  [L=454]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-12   47.4   3.2    4.3e-12   46.6   3.2    1.4  1  VWA       von Willebrand factor type A domain
    1.4e-09   38.5   0.7    9.6e-09   35.9   0.1    2.3  2  VWA_2     von Willebrand factor type A domain
    2.2e-08   34.2   0.2    3.8e-08   33.4   0.2    1.4  1  VWA_3     von Willebrand factor type A domain
    4.2e-06   26.9   0.2    8.5e-06   25.9   0.2    1.6  1  DUF2201   VWA-like domain (DUF2201)
    0.00026   20.4   0.1    0.00049   19.5   0.1    1.4  1  VWA_CoxE  VWA domain containing CoxE-like protein


Domain annotation for each model (and alignments):
>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.6   3.2   1.2e-15   4.3e-12       2     172 ..      41     207 ..      40     210 .. 0.79

  Alignments for each domain:
  == domain 1  score: 46.6 bits;  conditional E-value: 1.2e-15
                 EEEEEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSSEEEEEETTSHC..HHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHGT CS
         VWA   2 ivfvlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfssevktefslndys..skeellsalnnlkysgggttntgkalkyaleklfkssag 98 
                 iv++lD+Sgsm+++ ++++k +i++l+e++    ++  v l+++ ++++  ++l+++   ++++ l+++++    gggt+   +  ++  +  +++ ++
  EFC35949.1  41 IVIALDVSGSMRGQGIDQAKIAISNLFEQVV---DTPDVVLITYDTSAE-LYDLRKKPaeTRQSTLEQIQA----GGGTD-FTCVFEAISN--LDMFNR 128
                 9******************************...**********98765.579998663344555555555....56666.6666665544..344444 PP

                 SSTTSEEEEEEEESS--CSS.HTHHHHHHHH......GCTEEEEEEEESSSHHHHHHHHHSSSSC.HHCEEEESSHHHHHHH CS
         VWA  99 aRenakkviilltdGksndg.dpkeaaneak......eqgikvfavGvgnadekelLnkiasepg.eghvftvtdfeeleel 172
                    + +  i+++tdG++ ++ + ++a++++k       q  +++++G+ + ++ +lL++i + ++ +g++ +v+d +e+++ 
  EFC35949.1 129 ---QSEVAILFFTDGQDGSShKREKAIEQMKkvletkTQSFEFHTIGFTSSHDVALLTQITQLGSvQGTFQYVKDANEINQS 207
                 ...445789999*****7755777777777777777699*********99999999****8877788899999999987765 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9   0.1   2.7e-12   9.6e-09       1     107 []      41     141 ..      41     141 .. 0.84
   2 ?    0.6   0.0      0.25     9e+02      18      70 ..     149     212 ..     142     249 .. 0.62

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 2.7e-12
       VWA_2   1 lvfvlDtSgSmrngdygptrleaakdaveallksl.pgdrvglvtfsdgpevlipltkdkakilnalrnleakgggtnlaaaLqlark..alkkrrkge 96 
                 +v+ lD+SgSmr++      +++ak a+++l+++  ++  v l+t+++++e+    +k  ++ ++ l++++a  ggt+++  ++  ++  +++++    
  EFC35949.1  41 IVIALDVSGSMRGQ-----GIDQAKIAISNLFEQVvDTPDVVLITYDTSAELYDLRKKPAETRQSTLEQIQAG-GGTDFTCVFEAISNldMFNRQ---S 130
                 69***********9.....5*************994566*********999776667778888999*****95.888888888888862255544...5 PP

       VWA_2  97 krvivlitDge 107
                 +  i+++tDg+
  EFC35949.1 131 EVAILFFTDGQ 141
                 999999***96 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.25
       VWA_2  18 ptrleaakdaveallksl.........pgdrvglvtfsd..gpevlipltkdkakilnalrnle 70 
                 ++ +e++k+ +e+  +s+          +d   l +     +++  ++  kd ++i++ ++nl 
  EFC35949.1 149 EKAIEQMKKVLETKTQSFefhtigftsSHDVALLTQITQlgSVQGTFQYVKDANEINQSMENLI 212
                 3467777777777777665555555422333333333333334555555577777777777764 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.4   0.2   1.1e-11   3.8e-08       2     149 ..      40     189 ..      39     196 .. 0.82

  Alignments for each domain:
  == domain 1  score: 33.4 bits;  conditional E-value: 1.1e-11
       VWA_3   2 evvivvDvsssmsaen.klvkdaLsvalrqLptndkiavllfgtkprplfpgsravsaaelqealqkikelelslgasnlegaLkealrqp.akpgevr 98 
                 ++vi++Dvs sm++++ + +k a+s++ +q  +   + ++  +t+++    + r+  a+++q +l+ i++     g+++   + ++++      +++  
  EFC35949.1  40 QIVIALDVSGSMRGQGiDQAKIAISNLFEQVVDTPDVVLITYDTSAE--LYDLRKKPAETRQSTLEQIQA----GGGTDFTCVFEAISNLDmFNRQSEV 132
                 8*************99*****************************88..556666677899999988888....699**99999999975555669999 PP

       VWA_3  99 svilltDgssaqge...ervsdlisrar....ekirfhalglgsslsaamlqaLAeas 149
                 +++ +tDg++  ++   e++++++++      + + fh++g+ ss++ a+l ++ + +
  EFC35949.1 133 AILFFTDGQD-GSShkrEKAIEQMKKVLetktQSFEFHTIGFTSSHDVALLTQITQLG 189
                 *********5.54412266666666544555556*****************9998865 PP

>> DUF2201  VWA-like domain (DUF2201)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.2   2.4e-09   8.5e-06       1      78 [.      41     123 ..      41     164 .. 0.74

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 2.4e-09
     DUF2201   1 lvlavDtSgSikdkelarfaaeiadilrrleae..vhvvavdeevqsvqrlep...aeklaelqltggGGTdlvpvlEavakl 78 
                 +v+a+D+SgS++ + + + +  i+++ +++  +  v++++ d++ +     ++   +++ +  q++ gGGTd++ v+Ea+++l
  EFC35949.1  41 IVIALDVSGSMRGQGIDQAKIAISNLFEQVVDTpdVVLITYDTSAELYDLRKKpaeTRQSTLEQIQAGGGTDFTCVFEAISNL 123
                 799**************************95553477777787766555444444323333346789************9975 PP

>> VWA_CoxE  VWA domain containing CoxE-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.1   1.4e-07   0.00049      49     176 ..      30     155 ..      13     165 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.4e-07
    VWA_CoxE  49 rrkprerkprelvllvDvSgSmaaysaiflallhA.llqqlp...rtevfaFdtr..lvdlTralrerDpaeaLarvsaavedlgGgTrigaalaefle 141
                 +++  +rk++++v+ +DvSgSm       ++++ + l +q+    ++ ++++dt+  l dl ++ + + +++ L++++      gGgT+    ++++ +
  EFC35949.1  30 LISNIQRKEKQIVIALDVSGSMRGQGIDQAKIAISnLFEQVVdtpDVVLITYDTSaeLYDLRKKPA-ETRQSTLEQIQ-----AGGGTDFTCVFEAISN 122
                 55556788889***********98554444443321333332455888899998633778877766.67888999999.....9***********9999 PP

    VWA_CoxE 142 lvtrpaLsrravvvlvsDglergdreellaelarl 176
                 l  ++  +++ +++ ++Dg ++ ++++ +++++++
  EFC35949.1 123 LDMFNR-QSEVAILFFTDGQDGSSHKR-EKAIEQM 155
                 888888.77999*******88776543.3344433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (454 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       754  (0.0420548); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2845.29
//
Query:       EFC35950.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       571  (0.0318478); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 831.76
//
Query:       EFC35951.1  [L=149]
Description: hypothetical protein NAEGRDRAFT_54658 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0012   19.2   0.8     0.0017   18.7   0.8    1.4  1  GyrI-like  GyrI-like small molecule binding domain


Domain annotation for each model (and alignments):
>> GyrI-like  GyrI-like small molecule binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.8   9.6e-08    0.0017      80     153 ..      64     144 ..      12     146 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 9.6e-08
                 CGBTTSEEEEE-SEEEEEEEEECEGGGHHHHHHHHHHTHHHHTT-........EEEESEEEEEEECCCTSSCGCEEEEEEEE CS
   GyrI-like  80 egpeglefleipageyAvfrhkGpyddlqatyaklygewlpesgy........errdgpsiEiYlsdprereeelkteiyip 153
                 + + +++ ++ip+g y++ ++ Gpy +l  ++++l +e  ++ g         +  + p +Ei + + + ++eel  +++ +
  EFC35951.1  64 SYSLPIQLKTIPKGVYLKKHYVGPYMHLGRVWEELKTELSEKFGEiyeeapypSWEEHPNHEILMKEVP-KDEELISDLFTR 144
                 6778999******************99999999998888888888777777677788899999999888.888888888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       495  (0.0276089); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 993.56
//
Query:       EFC35952.1  [L=435]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.7    8.3   4.6        6.1    6.6   0.0    3.0  3  DUF842    Eukaryotic protein of unknown function (DUF842)


Domain annotation for each model (and alignments):
>> DUF842  Eukaryotic protein of unknown function (DUF842)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.0   0.00034       6.1      40      55 ..      28      43 ..      24      57 .. 0.82
   2 ?    0.8   0.1      0.02   3.6e+02      69     101 ..     216     243 ..     196     274 .. 0.62
   3 ?    0.6   0.3     0.023   4.1e+02      37      77 ..     365     405 ..     330     415 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.00034
      DUF842 40 kasresveqCvekCse 55
                k s ++veqC+e+C  
  EFC35952.1 28 KPSLDQVEQCIEHCDL 43
                55789*********75 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.02
      DUF842  69 eqfqerLqrcvmvCqdkakdklgpnssekqtak 101
                 ++fq + ++ + vCq  +k+kl+      ++++
  EFC35952.1 216 DSFQTKAHKLALVCQLVVKNKLE-----MDRNE 243
                 45555555555555555555552.....22222 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.023
      DUF842  37 ddrkasresveqCvekCseplqkaqkvvqqEleqfqerLqr 77 
                 d++k + e++++ +e+    +++ q++++  +e+ ++rL+ 
  EFC35952.1 365 DTHKHQLEEIKSNIEQIMILAEENQRTIDLQIEKAKDRLNH 405
                 56777788888889988888899999998888888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (435 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1003  (0.0559429); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2562.33
//
Query:       EFC35953.1  [L=409]
Description: hypothetical protein NAEGRDRAFT_60071, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.043   12.6   0.1      0.071   11.9   0.1    1.2  1  NRDD      Anaerobic ribonucleoside-triphosphate reductase


Domain annotation for each model (and alignments):
>> NRDD  Anaerobic ribonucleoside-triphosphate reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1     4e-06     0.071     403     498 ..      16     119 ..      12     131 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4e-06
                 -EEEEE---TTHHHHHHHHH..HH................HHG..........-SSSS-TTSSB-HHHHHHHHHHHTGGGTT-S-EEEEBSS--SSHHH CS
        NRDD 403 nfsleatPaEslsgrfakldkkkf..geipgvdke....pyYt..........NsfhvpvdekislfekikleaefqklttGGailyieldeekknpea 485
                  f++ +tPaE ++ +f +  kk +  g    + ++       +          N fh + ++   l + +++  + q++ ++G i+ i+ +e ++   +
  EFC35953.1  16 YFAVTKTPAEDTGAQFLQHMKKVYsdG----FVNGfvngY--NyrqssepkdhNIFHSHTNYV--LNQSLSVVIKAQRIPQAGIITKIFSQELQSFFPV 106
                 599*********************442....333334331..233555666669999999995..778888888999999*********9999999999 PP

                 HHHHHHHHHHTT- CS
        NRDD 486 leklvkiakktgi 498
                 l++l k+++ + +
  EFC35953.1 107 LSSLAKLIESNSL 119
                 9999997766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2585.61
//
Query:       EFC35954.1  [L=255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.2   0.6       0.17   11.6   0.1    1.5  2  DDE_3     DDE superfamily endonuclease


Domain annotation for each model (and alignments):
>> DDE_3  DDE superfamily endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   9.6e-06      0.17      84     136 ..      94     143 ..      52     150 .. 0.71
   2 ?   -3.9   0.0      0.58     1e+04      55      70 ..     210     225 ..     205     225 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.6e-06
       DDE_3  84 ilDnasiHkseslrelveeeadrlellylPpySPelNpiEivwsklkrellk.r 136
                 + D+ +    +  + l+   ++ l+l y+P yS  lN ++++ +++ r++++ +
  EFC35954.1  94 VKDQYKENETALAQTLL---WKPLVLYYFPNYSASLN-VKNWMHVMRRRVIHlQ 143
                 44444444444444444...559**************.69********999844 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 0.58
       DDE_3  55 feetlnaedfaefler 70 
                 ++e ++ +df++++++
  EFC35954.1 210 VYEVISDNDFEHHVKQ 225
                 5777888888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       795  (0.0443416); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1629.42
//
Query:       EFC35955.1  [L=243]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.014   15.2   0.1       0.02   14.7   0.1    1.3  1  Acetyltransf_2  N-acetyltransferase


Domain annotation for each model (and alignments):
>> Acetyltransf_2  N-acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.1   1.1e-06      0.02      82     159 ..      71     151 ..      56     229 .. 0.62

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.1e-06
                     SSSSCEEEEEEEEETTEEEEE-SSSSCG...-SS-EESSTTCEEEESSEEEEEEEETTCEEEEEEEETTEEE..EEEEEEEE CS
  Acetyltransf_2  82 astertHllllVtidgetylvDvGFGgs..tltaplelesgkdqqtthgifrlveeeenewvlekkkreewv..klYsftle 159
                       t  +H++++V   +  y+  ++FGg+   +  p + e+    +t   +++ +++ e +++le + +++ +    Y  +++
      EFC35955.1  71 NNTSINHAMFYVVSGEYYYIFETSFGGCseVYKIPTNTEPSGSVNTYNRKICRTNNSE-QFTLEFQDKNGTTkcICYVREIT 151
                     26999**********************9555566666666555555555555555555.66666666665552234433333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1269  (0.0707792); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1600.99
//
Query:       EFC35956.1  [L=210]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (210 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      600  (0.0334653); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1397.13
//
Query:       EFC35957.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-07   31.8   0.1    1.2e-07   31.8   0.1    2.7  3  Ribosomal_S30  Ribosomal protein S30


Domain annotation for each model (and alignments):
>> Ribosomal_S30  Ribosomal protein S30
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.8   0.1   6.8e-12   1.2e-07       2      23 ..       4      25 ..       3      57 .. 0.78
   2 ?   -0.2   2.1     0.068   1.2e+03      28      54 ..     114     139 ..      97     144 .. 0.73
   3 ?   -2.1   0.1      0.26   4.6e+03      37      43 ..     147     153 ..     130     156 .. 0.63

  Alignments for each domain:
  == domain 1  score: 31.8 bits;  conditional E-value: 6.8e-12
                   TBX-STTTTHHHHHS------- CS
  Ribosomal_S30  2 vhGsLarAGKVrnqTPKveKqe 23
                   +hGsLar GKV+ qTP+v+K  
     EFC35957.1  4 IHGSLARSGKVKWQTPRVAKTS 25
                   7*******************94 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.068
                    --THHHHHHHHHHHTTSSS--SSSSS- CS
  Ribosomal_S30  28 ptGRakkRlqYnrRfvnvvvggkkkkg 54 
                    +  Ra k++  n Rf +    ++kk +
     EFC35957.1 114 HEERAFKKQTRNGRFRS-EGRNHKKWH 139
                    55699999999999998.555555555 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.26
                    HHHHHTT CS
  Ribosomal_S30  37 qYnrRfv 43 
                     Y++R+v
     EFC35957.1 147 IYQKRMV 153
                    4666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       558  (0.0311228); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.33s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 1060.46
//
Query:       EFC35958.1  [L=280]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-09   37.0   7.8    0.00029   20.7   0.1    5.8  6  LRR_6     Leucine Rich repeat
    3.4e-09   36.8  13.7       0.16   12.5   3.5    5.8  6  LRR_4     Leucine Rich repeats (2 copies)
    3.2e-06   26.8  10.6      0.073   12.8   0.0    4.7  4  LRR_8     Leucine rich repeat
  ------ inclusion threshold ------
       0.14   12.8  11.1         11    7.1   0.0    6.8  9  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.1       2.7   1.2e+04       3      10 ..     102     109 ..     101     111 .. 0.76
   2 ?    3.4   0.2     0.022     1e+02       1      12 [.     124     135 ..     124     139 .. 0.89
   3 !   11.0   0.1   7.8e-05      0.35       2      23 ..     174     196 ..     173     197 .. 0.89
   4 ?    0.2   0.0      0.23     1e+03      14      24 .]     214     224 ..     213     224 .. 0.86
   5 !   20.7   0.1   6.4e-08   0.00029       2      24 .]     226     248 ..     225     248 .. 0.92
   6 ?    0.3   0.0      0.22   9.9e+02       2      13 ..     251     262 ..     250     266 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 2.7
       LRR_6   3 thLteLdL 10 
                 ++L +L L
  EFC35958.1 102 QTLHTLKL 109
                 68889877 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.022
       LRR_6   1 snthLteLdLsg 12 
                 +n++++ L+Ls 
  EFC35958.1 124 NNHTIQVLNLSR 135
                 79********96 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 7.8e-05
       LRR_6   2 nthLteLdLsgNd.IgDeGaeaL 23 
                  ++L+ LdL+ N  +gD+G+  +
  EFC35958.1 174 LSKLEILDLKQNTaFGDAGCAMI 196
                 589****************9776 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.23
       LRR_6  14 dIgDeGaeaLa 24 
                 +I D+G++ L+
  EFC35958.1 214 QIHDKGVTELS 224
                 699****9885 PP

  == domain 5  score: 20.7 bits;  conditional E-value: 6.4e-08
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  t+L+eLd++++dI+++G+  +a
  EFC35958.1 226 LTNLEELDVRFCDITNKGLVTIA 248
                 589****************9887 PP

  == domain 6  score: 0.3 bits;  conditional E-value: 0.22
       LRR_6   2 nthLteLdLsgN 13 
                 +++L++ ++ g+
  EFC35958.1 251 CSKLQTIHVGGC 262
                 89*******998 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.0   5.2e-05      0.23       1      30 [.      45      76 ..      36      84 .. 0.87
   2 ?    4.3   0.5     0.013        59       4      28 ..     129     155 ..     102     156 .. 0.53
   3 !   12.5   3.5   3.5e-05      0.16       2      34 ..     151     186 ..     150     193 .. 0.86
   4 ?   -0.7   0.0      0.48   2.2e+03      23      33 ..     200     209 ..     194     217 .. 0.71
   5 !   10.2   0.3   0.00018      0.82      12      40 ..     219     240 ..     200     244 .. 0.62
   6 !   10.1   0.0    0.0002      0.88       1      42 [.     227     270 ..     227     272 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.2e-05
                SS--EEE--.SS---E-S-HH.H-TT--EEE- CS
       LRR_4  1 pnLevLdLs.nNqltdiplle.klpnLkeLdL 30
                pnLe++ +   N ++d++ +  + +nL++Ld+
  EFC35958.1 45 PNLEIIRIEsRNFISDVGDCVaNWKNLQVLDC 76
                79999999988********6637********9 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.013
                 -EEE--SS---E-S-HH..H.-TT--EE CS
       LRR_4   4 evLdLsnNqltdiplle..k.lpnLkeL 28 
                 +vL+Ls   ++  + ++  + + nLk+L
  EFC35958.1 129 QVLNLSRATMS-EDVFNtiStFSNLKHL 155
                 45555553333.2333333225666655 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 3.5e-05
                 S--EEE--S...S---E-S-HHH-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsn...NqltdiplleklpnLkeLdLsgNn 34 
                 nL++L+  +   N l +++ l++l +L+ LdL +N+
  EFC35958.1 151 NLKHLYADSiigNSLNSLGKLANLSKLEILDLKQNT 186
                 9*******5555********************8884 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.48
                 TT--EEE-.-S CS
       LRR_4  23 pnLkeLdLsgN 33 
                 ++L++L++  N
  EFC35958.1 200 KSLRKLYV-MN 209
                 67777776.33 PP

  == domain 5  score: 10.2 bits;  conditional E-value: 0.00018
                 ---E-S-HHH-TT--EEE-.-S-----GG CS
       LRR_4  12 qltdiplleklpnLkeLdLsgNnlitdld 40 
                  +t++++   l+nL+eLd+ ++    d++
  EFC35958.1 219 GVTELSS---LTNLEELDVRFC----DIT 240
                 3666666...********9777....765 PP

  == domain 6  score: 10.1 bits;  conditional E-value: 0.0002
                 SS--EEE--SS---E-S-HH...H.-TT--EEE-.-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqltdiplle...k.lpnLkeLdLsgNnlitdldeL 42 
                 +nLe+Ld + + +t   +l    k + +L+++++ g++++ d+++L
  EFC35958.1 227 TNLEELDVRFCDITN-KGLVtiaKaCSKLQTIHVGGCSKV-DVNSL 270
                 7*************5.454445577*********999777.66655 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.4   0.0    0.0073        33      24      55 ..      44      75 ..      23      79 .. 0.60
   2 !    4.6   0.7    0.0061        27      22      57 ..     123     158 ..     102     159 .. 0.82
   3 !    7.8   4.2   0.00062       2.8      19      59 ..     147     185 ..     144     186 .. 0.85
   4 !   12.8   0.0   1.6e-05     0.073      22      61 .]     200     239 ..     197     239 .. 0.94

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.0073
                -TT--EEE-.-SS---GGGGGGGTT--S-.EEE CS
       LRR_8 24 lsnLkvLdL.snNllttlspgafsgLpsLrsLd 55
                 +nL+++ + s+N ++ +  ++ ++ ++L+ Ld
  EFC35958.1 44 TPNLEIIRIeSRNFISDV-GDCVANWKNLQVLD 75
                555555555334455555.35555555555554 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0061
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 k+++  +vL+Ls+ +++    +++s +++L++L+ +
  EFC35958.1 123 KNNHTIQVLNLSRATMSEDVFNTISTFSNLKHLYAD 158
                 6778899******99999778999999999999865 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.00062
                 TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 ++F++l++L   ++  N+l++l  g +++L++L+ LdL +N
  EFC35958.1 147 STFSNLKHLYADSIIGNSLNSL--GKLANLSKLEILDLKQN 185
                 4677777777778999******..7*************998 PP

  == domain 4  score: 12.8 bits;  conditional E-value: 1.6e-05
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 k+l++L v++L++ +++      +s+L++L++Ld++ +++
  EFC35958.1 200 KSLRKLYVMNLGEDQIHDKGVTELSSLTNLEELDVRFCDI 239
                 7899*******************************99886 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0         4   1.8e+04       7      13 ..      27      33 ..      24      41 .. 0.61
   2 ?   -0.9   0.0      0.96   4.3e+03       1      13 [.      46      59 ..      46      65 .. 0.73
   3 ?   -0.2   0.0       0.6   2.7e+03       1      12 [.      70      83 ..      70      90 .. 0.68
   4 ?   -1.4   0.1       1.4   6.4e+03       3       7 ..     129     133 ..     103     135 .. 0.62
   5 ?    1.8   0.3      0.13   5.8e+02       1      19 [.     151     167 ..     151     174 .. 0.63
   6 ?    1.2   0.0      0.19   8.7e+02       1      10 [.     176     185 ..     176     191 .. 0.89
   7 ?   -2.6   0.0       3.5   1.6e+04       1       7 [.     201     207 ..     201     218 .. 0.75
   8 ?    7.1   0.0    0.0024        11       1      15 [.     228     242 ..     228     250 .. 0.85
   9 ?    1.6   0.0      0.15   6.6e+02       1      11 [.     253     263 ..     253     274 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 4
       LRR_1  7 Lsnnpll 13
                L+++ ++
  EFC35958.1 27 LEYCGPT 33
                5666664 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.96
       LRR_1  1 nLrhLdL.snnpll 13
                nL+ + + s+n+++
  EFC35958.1 46 NLEIIRIeSRNFIS 59
                78888887777764 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.6
       LRR_1  1 nLrhLdL..snnpl 12
                nL++Ld    +n++
  EFC35958.1 70 NLQVLDCkfDRNHF 83
                89999963355554 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 1.4
       LRR_1   3 rhLdL 7  
                 ++L+L
  EFC35958.1 129 QVLNL 133
                 44555 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.13
       LRR_1   1 nLrhLd...Lsnnpllglppns 19 
                 nL+hL+   + +n+l     ns
  EFC35958.1 151 NLKHLYadsIIGNSL-----NS 167
                 89***8555555555.....33 PP

  == domain 6  score: 1.2 bits;  conditional E-value: 0.19
       LRR_1   1 nLrhLdLsnn 10 
                 +L+ LdL +n
  EFC35958.1 176 KLEILDLKQN 185
                 7******877 PP

  == domain 7  score: -2.6 bits;  conditional E-value: 3.5
       LRR_1   1 nLrhLdL 7  
                 +Lr+L++
  EFC35958.1 201 SLRKLYV 207
                 5899976 PP

  == domain 8  score: 7.1 bits;  conditional E-value: 0.0024
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL++Ld++ + ++++
  EFC35958.1 228 NLEELDVRFCDITNK 242
                 8*********99765 PP

  == domain 9  score: 1.6 bits;  conditional E-value: 0.15
       LRR_1   1 nLrhLdLsnnp 11 
                 +L+++++++++
  EFC35958.1 253 KLQTIHVGGCS 263
                 79********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       336  (0.0187406); expected 358.6 (0.02)
Passed bias filter:                      269  (0.0150036); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1823.02
//
Query:       EFC35959.1  [L=128]
Description: hypothetical protein NAEGRDRAFT_76376 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1081  (0.0602934); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 788.94
//
Query:       EFC35960.1  [L=437]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.43   10.6   2.2        4.3    7.4   1.4    2.6  2  PheRS_DBD2  PheRS DNA binding domain 2


Domain annotation for each model (and alignments):
>> PheRS_DBD2  PheRS DNA binding domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   1.4   0.00024       4.3      24      31 ..      17      24 ..      16      24 .. 0.96
   2 ?    0.4   0.0     0.038   6.8e+02       1      14 [.     361     374 ..     361     382 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00024
  PheRS_DBD2 24 nELKKRKL 31
                +++KKRKL
  EFC35960.1 17 QDYKKRKL 24
                8******9 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.038
  PheRS_DBD2   1 DeVqekLkliqeGk 14 
                 DeV ++L+ i++  
  EFC35960.1 361 DEVNQYLREINKSS 374
                 99********9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       651  (0.0363099); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2541.10
//
Query:       EFC35961.1  [L=167]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-23   81.8   1.4    6.7e-11   42.5   0.2    3.3  3  Sel1      Sel1 repeat
  ------ inclusion threshold ------
        1.1    9.2   4.3        1.6    8.7   0.1    2.9  3  TPR_1     Tetratricopeptide repeat
        1.9    8.6   4.8        1.2    9.2   0.2    2.5  2  MIT       MIT (microtubule interacting and transport) domain


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.052   3.1e+02      26      38 .]       2      14 ..       1      14 [. 0.89
   2 !   42.5   0.2   1.1e-14   6.7e-11       3      38 .]      18      51 ..      16      51 .. 0.96
   3 !   34.6   0.1   3.3e-12     2e-08       1      38 []      52      87 ..      52      87 .. 0.95

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.052
        Sel1 26 AiewyekAAeqGd 38
                A+ew+ k+ +q++
  EFC35961.1  2 AMEWLLKSVDQNN 14
                99******99986 PP

  == domain 2  score: 42.5 bits;  conditional E-value: 1.1e-14
        Sel1  3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                A+++ G  y++++Glg ++++++A+ewye+AAeqGd
  EFC35961.1 18 ALFNIG--YMFETGLGREQNYSEALEWYEMAAEQGD 51
                99****..***************************7 PP

  == domain 3  score: 34.6 bits;  conditional E-value: 3.3e-12
        Sel1  1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                +eA++ +G+fy  ++G+gv+kD+e+A+ewy kAA+ G+
  EFC35961.1 52 PEAQFTVGLFY--EFGKGVEKDEEQAREWYWKAARCGH 87
                79******777..***********************98 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.22   1.3e+03       2      11 ..      17      26 ..      16      27 .. 0.83
   2 ?    8.7   0.1   0.00026       1.6      15      29 ..      34      48 ..      30      49 .. 0.86
   3 ?   -0.1   0.2      0.16   9.5e+02      16      27 ..      71      82 ..      69      84 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.22
                HHHHHHHHHH CS
       TPR_1  2 kalynlGnay 11
                +al+n+G+++
  EFC35961.1 17 NALFNIGYMF 26
                599****876 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00026
                T-HHHHHHHHHHHHH CS
       TPR_1 15 gkydeAleyyekALe 29
                ++y eAle ye A e
  EFC35961.1 34 QNYSEALEWYEMAAE 48
                79*********9965 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.16
                -HHHHHHHHHHH CS
       TPR_1 16 kydeAleyyekA 27
                + ++A e y kA
  EFC35961.1 71 DEEQAREWYWKA 82
                558999999998 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.2    0.0002       1.2      17      32 ..      33      48 ..      30      49 .. 0.89
   2 ?    0.3   0.7      0.13   7.7e+02      41      56 ..      89     104 ..      66     106 .. 0.54

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0002
         MIT 17 agnyeeAlelYkeale 32
                ++ny+eAle+Y+ a e
  EFC35961.1 33 EQNYSEALEWYEMAAE 48
                89**********9976 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.13
         MIT  41 kneerrellrekieeY 56 
                 +++++ ell + +++Y
  EFC35961.1  89 DAQKKIELLNKSTQQY 104
                 2346677777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      501  (0.0279436); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1083.08
//
Query:       EFC35962.1  [L=167]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.063   13.7   2.5      0.094   13.1   2.5    1.3  1  PRP1_N      PRP1 splicing factor, N-terminal
      0.072   13.1   0.1      0.099   12.6   0.1    1.2  1  Lipoprot_C  Lipoprotein GNA1870 C terminal like


Domain annotation for each model (and alignments):
>> PRP1_N  PRP1 splicing factor, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   2.5   1.1e-05     0.094      50     111 ..      23      89 ..       2     108 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.1e-05
                 --------------------...----------------H.HHHHHHHHHHHHH.TT-------... CS
      PRP1_N  50 edlqdeendefegeseglfa...kaeydedDeeAdriyee.iderlderrkkrr.eakekeelekvr 111
                  +++d+e+ e+ + s++lf+    + +d++D++A +iy++ +d +l++ + k   +++ k+e+e+++
  EFC35962.1  23 PSQEDDEQSEILTFSSDLFSmnsFKLNDSEDRQAMEIYNQfLDTELARNHVKYSkHEEIKKEIERYQ 89 
                 223333344444444555552114478***********98579999877766540444556666554 PP

>> Lipoprot_C  Lipoprotein GNA1870 C terminal like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   1.1e-05     0.099       5      78 ..      39     113 ..      36     134 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.1e-05
                 EEEEEEEEEEE-SSBTTCEEEEEEEEEEEEEESB-BGGGS-SSSEEEEE.EEEEETTEEEEEEEEEEETTTTEEE CS
  Lipoprot_C   5 alvalriekiqdsekidklvakrsflvsdlagehtafdklpeggkaeyr.gkafssddadgkltytidfaakqgn 78 
                  l +++  k++dse  + +    +fl ++la +h  + k  e  k   r    +s+ d++g lt   d a  q  
  EFC35962.1  39 DLFSMNSFKLNDSEDRQAMEIYNQFLDTELARNHVKYSKHEEIKKEIERyQVKISTGDSEGDLTNIFDEAQIQIG 113
                 566777889*******************************99777543314568999**********99987744 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1389  (0.0774723); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.43
# Mc/sec: 1176.79
//
Query:       EFC35963.1  [L=660]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.31   11.2  13.4        0.7   10.1  13.4    1.6  1  Laminin_EGF   Laminin EGF domain
       0.41   11.1  17.7      0.057   13.8  12.6    2.2  2  EGF_2         EGF-like domain
       0.55   10.3   7.7       0.15   12.1   4.3    1.8  2  EGF_Tenascin  Tenascin EGF domain


Domain annotation for each model (and alignments):
>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1  13.4   0.00012       0.7       3      41 ..     555     599 ..     553     604 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00012
                  CCTTTBCC..SSEETTTECESBTTTEE.....STTS-EE-TTEEEG CS
  Laminin_EGF   3 Cnphgsss..ssCdsstgqClCkenve.....GrkCdrCkpgyygl 41 
                  C+ h + s  ++C+s +gqC C  n+e     G+kC+ C+ ++yg+
   EFC35963.1 555 CDRHVNCSnhGDCNS-EGQCICSSNYEegfwsGTKCEFCAINFYGK 599
                  666654444579*99.*********9555555************96 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8  12.6   9.5e-06     0.057       6      32 .]     559     589 ..     555     589 .. 0.71
   2 ?   -1.6   0.2      0.64   3.8e+03      23      32 .]     592     601 ..     591     601 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 9.5e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyq.....GktC 32 
                  +C++hG C+ ++GqC C+s+y      G +C
  EFC35963.1 559 VNCSNHGDCN-SEGQCICSSNYEegfwsGTKC 589
                 56*******9.679****88875433336666 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.64
       EGF_2  23 CdsgyqGktC 32 
                 C  +++Gk C
  EFC35963.1 592 CAINFYGKLC 601
                 67789***99 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       2.1   1.3e+04      13      18 ..      57      62 ..      57      66 .. 0.81
   2 ?   12.1   4.3   2.6e-05      0.15       6      23 ..     561     579 ..     558     589 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.1
  EGF_Tenascin 13 vDGqCi 18
                  vD +Ci
    EFC35963.1 57 VDSKCI 62
                  899999 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 2.6e-05
  EGF_Tenascin   6 CssRGvC.vDGqCiCDsEY 23 
                   Cs  G C  +GqCiC s+Y
    EFC35963.1 561 CSNHGDCnSEGQCICSSNY 579
                   *******558********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (660 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2642  (0.147359); expected 358.6 (0.02)
Passed bias filter:                      218  (0.0121591); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.79u 0.26s 00:00:01.05 Elapsed: 00:00:00.45
# Mc/sec: 4362.35
//
Query:       EFC35964.1  [L=920]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-06   28.1   0.9    0.00013   21.8   0.9    2.8  1  DDE_3     DDE superfamily endonuclease


Domain annotation for each model (and alignments):
>> DDE_3  DDE superfamily endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.9   7.1e-09   0.00013      61     135 ..     442     514 ..     361     523 .. 0.59

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 7.1e-09
       DDE_3  61 aedfaeflerlletalqakkivlilDnasiHkseslrelveeeadrlellylPpySPelNpiEi.vwsklkrellk 135
                  e++++++e++  +  ++ + +l++Dn+s Hk++s+++++++  ++   + lP   +++ p  + ++++ krel +
  EFC35964.1 442 IEHIEQWVEKVYIPNSKE-GDILLWDNLSHHKCKSVQKILKQ--HNRINILLPVGGHHQSPLDNmCFRYAKRELAD 514
                 234455555555555555.***********************..88888889999999999765378888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (920 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1519  (0.0847231); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.94u 0.35s 00:00:01.29 Elapsed: 00:00:00.56
# Mc/sec: 4927.21
//
Query:       EFC35965.1  [L=640]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (640 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1291  (0.0720062); expected 358.6 (0.02)
Passed bias filter:                      698  (0.0389313); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.84u 0.36s 00:00:01.20 Elapsed: 00:00:00.55
# Mc/sec: 3512.71
//
Query:       EFC35966.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-29  102.6   0.9    2.4e-29  102.4   0.9    1.0  1  p450      Cytochrome P450
  ------ inclusion threshold ------
      0.019   14.7   0.0      0.034   13.9   0.0    1.3  1  Coa1      Cytochrome oxidase complex assembly protein 1


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  102.4   0.9   2.6e-33   2.4e-29     138     316 ..      19     200 ..       4     213 .] 0.87

  Alignments for each domain:
  == domain 1  score: 102.4 bits;  conditional E-value: 2.6e-33
                 EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC.. CS
        p450 138 elditellskaaldvigsilFgarfdlledeklselvkaveelssllskssvqllllfpllkylptkllrklkeavkklkdlldklieerretldsa.. 234
                 ++++t+ l  ++l++i++++F  +++ + d++++  +++   +s+ll    ++++++ +l+ y+p  +++++k+a +++ ++++k+i ++ ++ ++a  
  EFC35966.1  19 NVNTTQELKSITLSIINRVAFDFNIE-IFDKNPEHRDEVHGWISDLLVGLLYKFVFPEWLFEYVPFGIFKRFKDAKNRFRETAMKMILKKTKEYENAnq 116
                 7999**********************.999999999999999***99999999999999*********************************9999988 PP

                 SCSSCSHHHHHHHHC..TTCTCT....SSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCCTTTT-HHH CS
        p450 235 kksrrdfldalllak..kekkge....sklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlgdkreptyd 316
                  k++ d+l++ll+++       +    + l+++el+  ++ ++faG++T+s+ l ++L +La++Pe+qekl eEid+ +++ ++++ +
  EFC35966.1 117 VKEDEDLLSLLLKSSnnG----KlteeERLTNDELVSAIFIIFFAGFETSSNSLNFMLRLLATRPEIQEKLIEEIDNEIPSMDSIKSK 200
                 779***********9531....2334689************************************************99777766554 PP

>> Coa1  Cytochrome oxidase complex assembly protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   3.8e-06     0.034      11      74 ..     148     208 ..     146     209 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 3.8e-06
        Coa1  11 vvvalayifnyektsssivrsvlyqlrrspevrelLGeeipfkssipwisGelntvkGkidlsf 74 
                 v ++++++f    tss+ ++ +l+ l + pe++e L e  +++++ip  +++++  ++ i+l++
  EFC35966.1 148 VSAIFIIFFAGFETSSNSLNFMLRLLATRPEIQEKLIE--EIDNEIP-SMDSIKSKESLINLNI 208
                 4566777888888999**********************..99*****.9********9999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       777  (0.0433376); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1344.77
//
Query:       EFC35967.1  [L=412]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00026   20.8   3.6    0.00048   20.0   3.6    1.4  1  dCache_1  Cache domain
     0.0058   16.0   0.0     0.0097   15.3   0.0    1.3  1  NucS      Endonuclease NucS


Domain annotation for each model (and alignments):
>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   3.6   5.4e-08   0.00048      83     247 ..     130     315 ..     102     317 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 5.4e-08
    dCache_1  83 dGqviassdpssppnlegtddpadrdwykealaggg...gkpvisdpyvdqtggkpvitiavpiyd.......dsgkfiGvlaadldldnlqdllsnik 171
                  G+++ ++++ +  +    ++pa++d++  +l++ +    + v+++py   + +   i+++  +yd        +   +G + ++l+l+++ ++ls+i 
  EFC35967.1 130 TGDIVKVNSTVDLTP----YVPAKQDFFIYTLKNYYekgLEGVYGEPYKVLG-STVAIYYSQLMYDpeiyklnKTKSLVGLAKVNLSLETIVNFLSKIE 223
                 466665555555544....5888888888888888888878889999*7667.9999999999997655444455688********************* PP

    dCache_1 172 lgetgyvfivdsdGniiahpdkdl....................lgknlrdelkaq....ealekalakiesgvssvklngeeylva.yapiptglgWy 245
                 l ++gyv++  ++ ++i ++  +                     l+k +++ ++ +    ++  k+           +++g +y+++ y+ + ++  W 
  EFC35967.1 224 LLGRGYVLVAQDNFIVIGGSIDTIsgdglnstnifdvksrnagsLMKQFYELNNRTfsilPSVMKI---------VGESDGVSYIITpYKYVLENMQWN 313
                 ********9977777777766333333455555555555555555555554443223232222222.........223567899999999888888887 PP

    dCache_1 246 lv 247
                 ++
  EFC35967.1 314 IF 315
                 65 PP

>> NucS  Endonuclease NucS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   1.1e-06    0.0097     115     161 ..     219     266 ..     191     282 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1.1e-06
        NucS 115 iehpdLieeGfkpvare.yavaiGivdiLgkdeegklvivelkrrkae 161
                 + +++L+++G+ +va++ + v  G +d ++ d  +++ i ++k+r+a+
  EFC35967.1 219 LSKIELLGRGYVLVAQDnFIVIGGSIDTISGDGLNSTNIFDVKSRNAG 266
                 5789**********99725555679********************775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (412 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       730  (0.0407162); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2436.55
//
Query:       EFC35968.1  [L=270]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      274  (0.0152825); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1726.63
//
Query:       EFC35969.1  [L=495]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.013   15.1   0.0        4.3    6.8   0.0    2.7  3  SGL         SMP-30/Gluconolactonase/LRE-like region
      0.032   13.6   0.1       0.13   11.7   0.0    1.9  2  tify        tify domain
       0.53   10.4   4.7        2.4    8.3   0.1    3.6  4  NHL         NHL repeat


Domain annotation for each model (and alignments):
>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.27   1.6e+03      53     104 ..      75     124 ..      67     128 .. 0.74
   2 ?    6.8   0.0   0.00072       4.3      10      59 ..     170     219 ..     165     249 .. 0.79
   3 ?    5.0   0.0    0.0027        16       4      61 ..     260     319 ..     258     356 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.27
         SGL  53 rlvvasksglalldlasgeletladeeedekpllrfNDgvvdpdGrlwfGtm 104
                  ++++ ++++ ++dl+s+++++ ++   ++++ + +N  ++ ++  l++++m
  EFC35969.1  75 CVIITDRDRIQVFDLHSRKFKKSIQF--QNYRINYLNIEKINQKEYLYVTSM 124
                 68899999999999999998888876..444666666666666667777777 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.00072
         SGL  10 eegaLlwvDilgqrihrldpatgketvldtpe.svGaiaprkdgrlvvask 59 
                  ++++l +D+  +rih ld+ tg++++  + + + G++++ +++ ++v+ +
  EFC35969.1 170 HDNQILVSDMSIGRIHVLDSITGMKVQEILAStPYGIAFL-NSNSFLVGDA 219
                 4789999****************9988555555*******.9999999864 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0027
         SGL   4 GpvwdeeegaLlwvDilgqrihrldpatgketvldtpe..svGaiaprkdgrlvvasksg 61 
                 G + d+ e+ +l v+i++++i+++++++++   +  ++  s G+  ++  g+l+v+++++
  EFC35969.1 260 GLLFDPIEKNILIVNIRKSQICAFKQENRSLIKTFKSGmfSYGMCLDQYTGELYVCNNDK 319
                 566677788888888888888888777766543333334788888885558888888765 PP

>> tify  tify domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   2.1e-05      0.13      13      30 ..     182     199 ..     182     200 .. 0.96
   2 ?   -2.0   0.0      0.39   2.4e+03      11      20 ..     308     317 ..     308     317 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.1e-05
        tify  13 GkVvVfDdvpaeKAkaIm 30 
                 G+++V D+++ +K+++I+
  EFC35969.1 182 GRIHVLDSITGMKVQEIL 199
                 9****************8 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.39
        tify  11 YgGkVvVfDd 20 
                 Y G+ +V+++
  EFC35969.1 308 YTGELYVCNN 317
                 89******96 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       1.1   6.5e+03      18      28 .]      79      87 ..      76      87 .. 0.51
   2 ?   -1.0   0.1      0.37   2.2e+03      12      19 ..     171     178 ..     168     186 .. 0.82
   3 ?    8.3   0.1   0.00041       2.4       4      28 .]     203     227 ..     201     227 .. 0.87
   4 ?    1.8   0.0      0.05     3e+02       6      21 ..     302     318 ..     302     323 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.1
                EECCCTEEEEE CS
         NHL 18 aDsenhrvqvF 28
                +D+   r+qvF
  EFC35969.1 79 TDRD--RIQVF 87
                5554..55555 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.37
                 TTEEEEEE CS
         NHL  12 nGdiyVaD 19 
                 +++i+V+D
  EFC35969.1 171 DNQILVSD 178
                 7999**99 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00041
                 EEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqvF 28 
                 P G+a ++++ ++V D +n  ++++
  EFC35969.1 203 PYGIAFLNSNSFLVGDACNDNIHIY 227
                 669*************999888776 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.05
                 EEEEE.TTTEEEEEECC CS
         NHL   6 Gvavd.snGdiyVaDse 21 
                 G ++d  +G++yV+++ 
  EFC35969.1 302 GMCLDqYTGELYVCNND 318
                 66777779******964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (495 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4551  (0.253835); expected 358.6 (0.02)
Passed bias filter:                     1240  (0.0691617); expected 358.6 (0.02)
Passed Vit filter:                       898  (0.0500865); expected 17.9 (0.001)
Passed Fwd filter:                       208  (0.0116013); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 2.45u 0.42s 00:00:02.87 Elapsed: 00:00:00.69
# Mc/sec: 2167.65
//
Query:       EFC35970.1  [L=205]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.2e-11   43.4   0.9    5.1e-11   42.8   0.3    1.6  2  BTB_2     BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.8   0.3   2.9e-15   5.1e-11      10      88 ..       2      83 ..       1      86 [. 0.85
   2 ?   -2.4   0.0      0.36   6.5e+03       4       8 ..     144     148 ..     125     182 .. 0.60

  Alignments for each domain:
  == domain 1  score: 42.8 bits;  conditional E-value: 2.9e-15
                EEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-B---....TTS-HHHHHHHHHHHT--T CS
       BTB_2 10 fetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtggkLhrp....eevelkslleElefyglee 88
                f+ts +tL+   dt+++   + +   +++e++n+yf+DR  + F+ iLny+r  ++++++    +  +l  + eE+ +y++++
  EFC35970.1  2 FSTSLQTLKSVKDTFFTGYFNDHFSPTVEEDDNAYFIDRPFEQFQLILNYLRG-IDIKEQvenlNGNDLVGFVEEVVYYQITP 83
                99****************999666999*************************9.77766511114567889*********986 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.36
                 EETTE CS
       BTB_2   4 nVgGt 8  
                 nV Gt
  EFC35970.1 144 NVLGT 148
                 33333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       543  (0.0302861); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.53
# Mc/sec: 1173.89
//
Query:       EFC35971.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00043   20.3   2.5     0.0011   19.0   2.5    1.7  1  Insulin_TMD     Insulin receptor trans-membrane segment
  ------ inclusion threshold ------
      0.019   15.2   0.4      0.038   14.2   0.4    1.5  1  DUF2782         Protein of unknown function (DUF2782)
      0.029   14.4   3.6      0.053   13.6   3.6    1.4  1  DUF2273         Small integral membrane protein (DUF2273)
      0.069   11.9   0.0       0.57    8.9   0.0    1.9  2  DUF2207         Predicted membrane protein (DUF2207)
      0.072   12.7   0.0       0.33   10.6   0.0    1.9  2  Baculo_11_kDa   Baculovirus 11 kDa family
      0.089   12.3   0.0       0.14   11.7   0.0    1.2  1  DUF5385         Family of unknown function (DUF5385)
       0.11   12.8   0.2       0.31   11.3   0.2    1.8  1  Chordopox_A13L  Chordopoxvirus A13L protein
       0.14   12.4   5.1        1.7    9.0   0.2    3.2  3  Sigma_reg_N     Sigma factor regulator N-terminal
       0.16   10.7   2.9        6.6    5.4   0.1    2.5  3  DUF2206         Predicted membrane protein (DUF2206)
       0.26   11.2   0.0       0.26   11.2   0.0    2.4  3  TMEM154         TMEM154 protein family
       0.27   11.3   1.2        6.4    6.9   0.0    2.7  3  DHHC            DHHC palmitoyltransferase
        0.6   10.2   7.7        1.2    9.2   7.7    1.9  1  ETRAMP          Malarial early transcribed membrane protein (


Domain annotation for each model (and alignments):
>> Insulin_TMD  Insulin receptor trans-membrane segment
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   2.5   7.3e-07    0.0011      16      44 ..     300     328 ..     292     330 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 7.3e-07
  Insulin_TMD  16 kIvigPviciillllvigavfvvvkKrQt 44 
                   +v +  i++i++++vig+ +++ kK+Q 
   EFC35971.1 300 IVVLVGFILMIIIAIVIGVGYYIYKKKQG 328
                  4788899*********************5 PP

>> DUF2782  Protein of unknown function (DUF2782)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.4   2.5e-05     0.038       8      72 ..     269     334 ..     258     343 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.5e-05
     DUF2782   8 vPppp.peeleedeelepevtiikkgeetieEYrvnGklymikvtPkigppYYLvdkdgdgkleek 72 
                 +P+p  p++++++++     tii ++ ++ +   + G ++mi +   ig+ YY+++k++  +  ++
  EFC35971.1 269 TPSPNkPSTSSNKPTSSSAGTIITEKGDKSYIVVLVGFILMIIIAIVIGVGYYIYKKKQGQTAPQN 334
                 23332356667777788889**********99**********************998764333333 PP

>> DUF2273  Small integral membrane protein (DUF2273)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   3.6   3.5e-05     0.053      21      43 ..     300     322 ..     298     327 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3.5e-05
     DUF2273  21 liltiGFwktLliillvliGyyi 43 
                 +++++GF+ +++i++++++Gyyi
  EFC35971.1 300 IVVLVGFILMIIIAIVIGVGYYI 322
                 6899******************9 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0       0.1   1.5e+02     369     405 ..       2      38 ..       1     151 [. 0.77
   2 ?    8.9   0.0   0.00038      0.57     155     237 ..     211     327 ..     188     342 .. 0.59

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.1
     DUF2207 369 rgyfdkkgkkklkklsalglgliilglilillallll 405
                 +++fd++g+ k ++ + ++l l+i +l+l++l++ + 
  EFC35971.1   2 KRFFDSAGRVKSFSHHEYLLSLFISSLLLMMLLFSTT 38 
                 6899999999999999999999999988876655443 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00038
     DUF2207 155 tftarnlppgeglevrvlf...................................ptnnarktsgnkldeilkeeqk....ntreraarlslallillil 214
                 ++t+  l++++g+++ ++                                    p  n+ + s nk+++  +   k    ++    +++    +i++++
  EFC35971.1 211 RVTTTILSSQQGATASTYSvvcstthwpssfaliaqpitpptsssgktpqptpsP--NKPTPSPNKPSTSSN---KptssSAGTIITEKGDKSYIVVLV 304
                 5667777777777777777777888888877777777777777766664433321..222222222222222...122244444555556667777888 PP

     DUF2207 215 llilllllllllliklllwkkyg 237
                   il++++++++ + ++++kk+ 
  EFC35971.1 305 GFILMIIIAIVIGVGYYIYKKKQ 327
                 88888888888888877777743 PP

>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       1.1   1.7e+03      46      61 ..      24      39 ..      18      53 .. 0.59
   2 ?   10.6   0.0   0.00022      0.33      34      72 ..     297     335 ..     296     343 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.1
  Baculo_11_kDa 46 fvvivlfilLlvvilk 61
                   f+  +l+++Ll++ ++
     EFC35971.1 24 FISSLLLMMLLFSTTT 39
                   4455555566554433 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00022
  Baculo_11_kDa  34 rdFvLvicglvvfvvivlfilLlvvilknaeaeeaekek 72 
                    +++++v+ g++++++i + i + ++i k+++ ++a +++
     EFC35971.1 297 KSYIVVLVGFILMIIIAIVIGVGYYIYKKKQGQTAPQNQ 335
                    689************************999888876655 PP

>> DUF5385  Family of unknown function (DUF5385)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   9.1e-05      0.14       6      37 ..     306     336 ..     303     344 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 9.1e-05
     DUF5385   6 liiliiiiiiilvivfllrkkkkqkeeekagg 37 
                 + il+iii+i++ + ++++kkk+ + + ++++
  EFC35971.1 306 F-ILMIIIAIVIGVGYYIYKKKQGQTAPQNQN 336
                 3.455555554444555577777665554443 PP

>> Chordopox_A13L  Chordopoxvirus A13L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.2   0.00021      0.31       5      35 ..     306     335 ..     302     344 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00021
  Chordopox_A13L   5 lllliiCvaivglivYgiYnrkketqttnps 35 
                     ++l+ii ++++g+  Y iY++k+ +  ++ +
      EFC35971.1 306 FILMIIIAIVIGV-GYYIYKKKQGQTAPQNQ 335
                     7888887777775.688**999887776655 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.2      0.34   5.1e+02      19      49 ..      23      53 ..      16      57 .. 0.74
   2 ?    2.8   0.0     0.097   1.4e+02      37      62 ..     148     173 ..     135     191 .. 0.70
   3 ?    9.0   0.2    0.0011       1.7      16      42 ..     300     326 ..     298     337 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.34
  Sigma_reg_N 19 slivlllifvilvvtllylaekegnklrevl 49
                  +i+ ll++++l++t+ + a++++n+l  ++
   EFC35971.1 23 LFISSLLLMMLLFSTTTINATSSDNNLAPTY 53
                 5677888888888888888888888776555 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.097
  Sigma_reg_N  37 laekegnklrevlelaveitsPNvyv 62 
                    ++++++++    ++v++t+PN+  
   EFC35971.1 148 SGSSSNENTDGLPANTVKLTNPNTVT 173
                  355556666788899********965 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.0011
  Sigma_reg_N  16 vlislivlllifvilvvtllylaekeg 42 
                  +++ ++++l+i++ +v++  y++ k++
   EFC35971.1 300 IVVLVGFILMIIIAIVIGVGYYIYKKK 326
                  678899999999999*******55554 PP

>> DUF2206  Predicted membrane protein (DUF2206)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.1    0.0044       6.6     220     249 ..      25      54 ..       4      73 .. 0.78
   2 ?   -2.2   0.1      0.91   1.4e+03      73     115 ..     131     172 ..     127     184 .. 0.77
   3 ?    5.1   0.1    0.0054       8.1      90     141 ..     277     328 ..     272     335 .. 0.69

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0044
     DUF2206 220 isvflvvllLfnsGfiyeivkdsptsiald 249
                 is +l+++lLf+++ i+++  d+   + ++
  EFC35971.1  25 ISSLLLMMLLFSTTTINATSSDNNLAPTYK 54 
                 677889999***********9998776665 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.91
     DUF2206  73 afktiasivnkilssiateflnptttqglavitkqissllhtv 115
                 +f +i  +v+ i+  +a++++++++t gl + t + +++  tv
  EFC35971.1 131 VFDNIPTVVSTIAGVAASGSSSNENTDGLPANTVKLTNPN-TV 172
                 6889999999999999999999999999988877777665.44 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0054
     DUF2206  90 teflnptttqglavitkqissllhtvskylhliiqfliviGvlsvlflrkkk 141
                 t++ +pt +++  +it++       v +   l+i   iviGv + ++++k+ 
  EFC35971.1 277 TSSNKPTSSSAGTIITEKGDKSYIVVLVGFILMIIIAIVIGVGYYIYKKKQG 328
                 6666788888888888777666655555555566666899999988987664 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.1       4.5   6.7e+03      19      23 ..      37      41 ..      18      59 .. 0.57
   2 ?   -1.8   0.7       1.8   2.6e+03      60      68 ..     176     184 ..     146     239 .. 0.63
   3 ?   11.2   0.0   0.00017      0.26      22      88 ..     263     328 ..     239     345 .. 0.58

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.5
     TMEM154 19 eesad 23
                +++++
  EFC35971.1 37 TTTIN 41
                33333 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.8
     TMEM154  60 lmiiiPlvl 68 
                 lm ++P  +
  EFC35971.1 176 LMTVVPTSV 184
                 333333333 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00017
     TMEM154  22 adatsaasteseslk........qeeakeslssaelsnesdqlelvlmiiiPlvllillllvviiliqkkkrkrs 88 
                   +           +        ++ +k + ssa +  ++   +  +++++  +l+i++ +v+ +   ++k+k+ 
  EFC35971.1 263 PSPNK---------PtpspnkpsTSSNKPTSSSAGTIITEKGDKSYIVVLVGFILMIIIAIVIGVGYYIYKKKQG 328
                 11112.........1222233444566667777777777777777889999999999998887776544444433 PP

>> DHHC  DHHC palmitoyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.1      0.12   1.9e+02      55      81 ..      20      46 ..       8      63 .. 0.58
   2 ?   -1.4   0.0       1.5   2.3e+03      66      71 ..     190     195 ..     138     244 .. 0.61
   3 ?    6.9   0.0    0.0043       6.4      41      83 ..     289     331 ..     285     344 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.12
        DHHC 55 llylllllilalvlllialvklveeek 81
                ll+l+++++l ++ll+ + + + ++++
  EFC35971.1 20 LLSLFISSLLLMMLLFSTTTINATSSD 46
                444444444444444444444444444 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.5
        DHHC  66 lvllli 71 
                 + l+ i
  EFC35971.1 190 VALSRI 195
                 223333 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0043
        DHHC  41 nciGerNykyFllfllylllllilalvlllialvklveeekks 83 
                 + i e+  k ++++l+ ++l++i+a+v+ + ++++  ++ ++ 
  EFC35971.1 289 TIITEKGDKSYIVVLVGFILMIIIAIVIGVGYYIYKKKQGQTA 331
                 6688888899*************99999998888877766655 PP

>> ETRAMP  Malarial early transcribed membrane protein (ETRAMP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   7.7   0.00083       1.2      33      83 .]     277     326 ..      21     326 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00083
      ETRAMP  33 ekakkaikkiddkiekkkkkkKliiistiatalallvasalGlgiykkkka 83 
                   ++k + +   +i    k  K  i  +++ +l++ +a+++G+g+y +kk+
  EFC35971.1 277 TSSNKPTSSSAGTIITE-KGDKSYIVVLVGFILMIIIAIVIGVGYYIYKKK 326
                 55666666666666666.89999**************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1097  (0.0611858); expected 358.6 (0.02)
Passed bias filter:                      673  (0.037537); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.74u 0.34s 00:00:01.08 Elapsed: 00:00:00.56
# Mc/sec: 1872.20
//
Query:       EFC35972.1  [L=310]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.051   13.1   0.2      0.071   12.7   0.2    1.2  1  Filament  Intermediate filament protein


Domain annotation for each model (and alignments):
>> Filament  Intermediate filament protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2     4e-06     0.071     164     242 ..     153     236 ..     145     273 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4e-06
                 XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXX-HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament 164 kld...Lteilkeiraqyeelaeknreeaeewykskleelqeaa..eknsealrsakeeitelrrqiqsleieleslkkqkasl 242
                 kl+   L++il+ei+    ++++k +++ e++++  l++  ++    +++++ ++   e+++++r+  ++   +++ +k+k+ +
  EFC35972.1 153 KLEgnsLKTILEEIKWSDSRIVQKRNKKGERVFQLTLKQDGKHTygVHEKDKWKNKTFEVNDTNRNFAEKMLGIDDAQKKKQFW 236
                 5555559***************************988775444311466788999999*********************99855 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       807  (0.0450109); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 1858.68
//
Query:       EFC35973.1  [L=239]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.5e-06   26.4   2.8       0.78   10.7   0.2    4.1  4  WD40         WD domain, G-beta repeat
      0.007   15.7   1.2      0.048   13.0   0.1    2.3  3  WD40_like    WD40-like domain
     0.0076   16.5   0.0        5.6    7.3   0.0    3.1  3  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.66   3.9e+03      33      38 .]     103     108 ..     101     108 .. 0.93
   2 ?    3.9   0.0     0.019   1.1e+02       1      26 [.     112     137 ..     112     145 .. 0.83
   3 !    9.1   0.0   0.00043       2.6       5      30 ..     157     183 ..     150     189 .. 0.76
   4 !   10.7   0.2   0.00013      0.78      12      37 ..     207     234 ..     194     235 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.66
                 EEEEEE CS
        WD40  33 tvriWd 38 
                 tv++Wd
  EFC35973.1 103 TVKMWD 108
                 8****9 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.019
                 TEEEEEEESSSSEEEEEEETTSSEEE CS
        WD40   1 gqclrtltGHssvtslafspdgawla 26 
                 g+c +++ + s v sl +sp +++++
  EFC35973.1 112 GKCFQEFQTNSRVLSLTNSPASDLIV 137
                 689999999988***********987 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00043
                 EEEESS.SSEEEEEEETTSSEEEEEET CS
        WD40   5 rtltGH.ssvtslafspdgawlasGsd 30 
                 +    H ++v   +fsp g++++sG +
  EFC35973.1 157 HNVIKHsDCVLTTKFSPKGNYIISGAK 183
                 55566844488889**********984 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00013
                 SE..EEEEEETTSSEEEEEETTSEEEEE CS
        WD40  12 sv..tslafspdgawlasGsdDgtvriW 37 
                 sv  +++  s dg++++ G++D+++ ++
  EFC35973.1 207 SVlsCDVVSSTDGDYISVGTWDNKISLY 234
                 562345559****************997 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0     0.059   3.5e+02     134     178 ..      85     130 ..      56     140 .. 0.71
   2 ?    1.7   0.0     0.021   1.3e+02       3      50 ..     124     171 ..     122     171 .. 0.86
   3 !   13.0   0.1   8.1e-06     0.048       6      70 ..     169     236 ..     164     238 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.059
   WD40_like 134 iysLsesafivfdlfsqnieykisvkdiktfeii.enkdilligte 178
                    + +  ++  d  s+++ +  +++ +k+f+ +  n+ +l ++++
  EFC35973.1  85 KKNILDLDLVQLDKVSEETVKMWDINSGKCFQEFqTNSRVLSLTNS 130
                 5555667788888999999999999999999988556777777665 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.021
   WD40_like   3 iYsidiskkgslilyGgkddkctvlkleslesvsivesfedSvifvkl 50 
                 + s+  s+ ++li+yG +d  + +++ +++     v + +d v+ +k+
  EFC35973.1 124 VLSLTNSPASDLIVYGLEDGGLDLVTYKTQSNSHNVIKHSDCVLTTKF 171
                 5677789999*****************999999999999999987776 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 8.1e-06
   WD40_like   6 idiskkgslilyGgkddkctvlkleslesvsivesfedSvifvkll...dddlilvvtlDGtillsll 70 
                   +s+kg++i+ G+k   +t+  ++        e +++Sv+ + ++   d+d i v+t D +i+l++l
  EFC35973.1 169 TKFSPKGNYIISGAKGGMLTISGVDACFRQLASELLSNSVLSCDVVsstDGDYISVGTWDNKISLYKL 236
                 5789***************************************998333467999********99887 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.011        65      58      85 ..     100     125 ..      96     129 .. 0.85
   2 !    7.3   0.0   0.00093       5.6       4      65 ..     130     190 ..     127     211 .. 0.84
   3 ?    1.3   0.0     0.072   4.3e+02      48      66 ..     217     235 ..     212     237 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.011
  ANAPC4_WD40  58 sdgevrlldaesgkvvhslsvksekavt 85 
                  s+ +v++ d++sgk+ ++++++s   v 
   EFC35973.1 100 SEETVKMWDINSGKCFQEFQTNSR--VL 125
                  7889***************99987..55 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.00093
  ANAPC4_WD40   4 cptmDLiAlatedgellvfRlngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrll 65 
                  +p  DLi ++ edg l +   + q   +    k++  v   +++p+g+ +  + + g + + 
   EFC35973.1 130 SPASDLIVYGLEDGGLDLVTYKTQSNSHN-VIKHSDCVLTTKFSPKGNYIISGAKGGMLTIS 190
                  8999***********99998888765554.46778999999********9999999988775 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.072
  ANAPC4_WD40  48 pdgklLavaysdgevrlld 66 
                   dg  + v++ d++++l++
   EFC35973.1 217 TDGDYISVGTWDNKISLYK 235
                  699999*********9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1386.04
//
Query:       EFC35974.1  [L=112]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.054   13.1   0.2      0.066   12.8   0.2    1.2  1  DUF1624   Protein of unknown function (DUF1624)
      0.084   12.8   0.0       0.11   12.5   0.0    1.1  1  TetR_C_3  YcdC-like protein, C-terminal region


Domain annotation for each model (and alignments):
>> DUF1624  Protein of unknown function (DUF1624)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.2   7.3e-06     0.066       1      20 [.      62      81 ..      62     110 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.3e-06
     DUF1624  1 RieeiDalRGiAlilMiifH 20
                R+ ++D++RG++++lMii++
  EFC35974.1 62 RMVALDIMRGMTIMLMIIVN 81
                899**************986 PP

>> TetR_C_3  YcdC-like protein, C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   1.2e-05      0.11       6      60 ..      24      78 ..      20      87 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.2e-05
                HHHHHHHHH--TTS-HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHTTSTTTHHH CS
    TetR_C_3  6 etwlealkeleeeddPaealaayiraKleisrdkPeasrlfanEilqGapllkee 60
                +++l++ +++++++dP    +a +++ +  +   P++ r+ a++i++G + +   
  EFC35974.1 24 QQLLSSGTAVNNNEDPSPSSSAAVTTEITTTNAPPRKERMVALDIMRGMTIMLMI 78
                5778888999**************************************9988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (112 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       537  (0.0299515); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 710.41
//
Query:       EFC35975.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       949  (0.052931); expected 358.6 (0.02)
Passed bias filter:                      620  (0.0345808); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 807.49
//
Query:       EFC35976.1  [L=646]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0019   18.3  17.6     0.0019   18.3  17.6    2.5  2  UPF0242     Uncharacterised protein family (UPF0242) N-termin
  ------ inclusion threshold ------
      0.026   14.1   3.7      0.041   13.5   2.1    2.0  2  HXXSHH      Protein of unknown function (DUF1552)
       0.11   12.9   0.0       0.36   11.2   0.0    1.9  1  DUF3085     Protein of unknown function (DUF3085)


Domain annotation for each model (and alignments):
>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   5.6       1.9   1.2e+04      57     151 ..     330     420 ..     326     436 .. 0.45
   2 !   18.3  17.6   3.2e-07    0.0019      78     172 ..     538     636 ..     510     644 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 1.9
     UPF0242  57 wekalkeklekskleekeaklteldeglktkeealeelqeeeeeLkeeldakeeelerlkeenqqLqekleaiaedfeelkleleeqLaekqell 151
                 +e+ ++e + ++ ++++++ +  ++     ++e++e+++ ee+ L   + a +ee    ++ n +++++ ++ + +++ ++   + +La +q+  
  EFC35976.1 330 FENYVHETFGTNSNKNNQSIVNRKPAISVFEDENIEKSTIEEQYL---FGAEDEEPSMETNVNRNFEKRPSQ-QSNNQFSSPLKKRKLASQQLIS 420
                 555555666555555555555555522223344455554444444...344444444444555555544433.2222222222233444444444 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 3.2e-07
     UPF0242  78 teld....eglktkeealeelqeeeeeLkeeldakeeelerlkeenqqLqekleaiaedfeelkleleeqLaekqellqeyqetieeqrsvlekrqdqi 172
                 t+ +    e+l++ ++ + +l++e e  +++l++ + ++e+l+ en++L+++ + i++ +ee + e e++ + +++ +q ++e+i eq+ +++ ++   
  EFC35976.1 538 TNRSsilnESLRERDDIIDQLNNEAEGERRKLKEYKLLIEKLQSENAHLKQQNSSIKKKNEEILIETEKENNTRELEIQSLKEKIAEQQTTINLQNLSK 636
                 22224445999*******************************************************************************998665555 PP

>> HXXSHH  Protein of unknown function (DUF1552)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.15     9e+02     246     269 ..       9      33 ..       1      52 [. 0.82
   2 ?   13.5   2.1   6.8e-06     0.041     101     222 ..     470     601 ..     462     632 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.15
      HXXSHH 246 facDltrvatlql.gneesnrtype 269
                 fa+D+ r+  l++ +n++++ t+++
  EFC35976.1   9 FATDFERISGLKFvSNGNQSPTFQM 33 
                 99***********999999888875 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 6.8e-06
      HXXSHH 101 psLelgvesgrgkssaysstisysgpgrpipp..ennPreaFsrL.....Fgsgaggs...eeaeaaarrlarrksvlDlvledakslkrkLgaa...d 186
                 p Le g+ +gr+ ++++  + sy +pg+p+    ennP+ + s+           +++   ++++  ++++ +r s+l   l++ +++ ++L+++   +
  EFC35976.1 470 PILEAGLYTGRSRDRKSRIKSSYYEPGSPLNTglENNPSMIISSSpllkyT---VPSTesaSNNNMLNDSITNRSSILNESLRERDDIIDQLNNEaegE 565
                 779999999998899999999********974449******9986665632...22223456677788899***********************9999* PP

      HXXSHH 187 rqKLdeylesvreiekrlekaekwaptakaeagasa 222
                 r+KL ey   ++++  + ++ ++++++ k+++++  
  EFC35976.1 566 RRKLKEYKLLIEKLQSENAHLKQQNSSIKKKNEEIL 601
                 ******************888887776666665443 PP

>> DUF3085  Protein of unknown function (DUF3085)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0     6e-05      0.36      21      59 ..      43      82 ..      36     110 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6e-05
     DUF3085 21 adgqkklvaYaeecdPktnp.edwwevkrqelGgDdgvef 59
                + +++k  +Y  e  P+ n+     + k+ ++GgDd   f
  EFC35976.1 43 TSNKRKRQIYDSEISPDDNNySTSIQSKQYHIGGDDTFSF 82
                456677889***********9999************8876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (646 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2494  (0.139104); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.28s 00:00:01.02 Elapsed: 00:00:00.48
# Mc/sec: 4077.46
//
Query:       EFC35977.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.3e-22   79.1  27.9    1.2e-18   66.9   1.7    2.4  2  MAD              Mitotic checkpoint protein
     0.0018   18.0  17.4     0.0018   18.0  17.4    2.0  2  DUF4201          Domain of unknown function (DUF4201)
  ------ inclusion threshold ------
      0.082   13.4   4.5       0.83   10.2   0.2    3.0  3  MerR-DNA-bind    MerR, DNA binding
       0.11   12.3   0.2       0.11   12.3   0.2    2.2  2  Orthopox_B11R    Orthopoxvirus B11R protein
       0.31   11.3  17.6       0.28   11.4   1.2    3.0  3  Seryl_tRNA_N     Seryl-tRNA synthetase N-terminal domain
       0.36   10.1  11.3       0.96    8.7   9.0    2.0  2  HemX             HemX, putative uroporphyrinogen-III C-methyl
       0.77    8.6   6.5       0.85    8.4   6.5    1.1  1  LMBR1            LMBR1-like membrane protein
       0.84    9.4  12.3          1    9.1  12.3    1.1  1  DUF445           Protein of unknown function (DUF445)
          1    9.6  19.6       0.23   11.7   9.5    2.6  2  ATG16            Autophagy protein 16 (ATG16)
          1   10.3  18.9        3.5    8.6  14.5    2.8  2  PRKG1_interact   cGMP-dependent protein kinase interacting do
        2.3    7.9  10.9        4.4    7.0  10.9    1.6  1  AAA_11           AAA domain
        2.6    7.4  21.3        6.4    6.2   1.4    2.8  2  LRRFIP           LRRFIP family
        2.7    8.0  11.2        4.8    7.2   0.6    3.8  4  DASH_Dad4        DASH complex subunit Dad4
        4.2    6.8  10.1        1.6    8.2   6.3    1.9  2  Allexi_40kDa     Allexivirus 40kDa protein
        5.4    7.1   8.3         21    5.2   0.3    2.3  2  Cob_adeno_trans  Cobalamin adenosyltransferase
        5.7    7.5  17.1        4.6    7.8   1.2    3.6  3  Cep57_MT_bd      Centrosome microtubule-binding domain of Cep
          8    6.0  14.1        6.4    6.3   2.9    3.0  3  Fzo_mitofusin    fzo-like conserved region


Domain annotation for each model (and alignments):
>> MAD  Mitotic checkpoint protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0  22.4   1.2e-05     0.012     141     298 ..      16     160 ..       1     177 [. 0.62
   2 !   66.9   1.7   1.1e-21   1.2e-18     586     661 .]     178     250 ..     153     250 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.2e-05
         MAD 141 ldllkkklseleqliqqlekkqkelaeaeqrikeLefeiqsqeddslivknskselaripelekelerlreenkklnelkenkelLkEevedlkkkLer 239
                   +++ +  e++ l +++e  + + ++ + +i+eL        + + ++k+ k+el    e +k+++ l++e +k +e+ + +e+LkE ++d+++ L +
  EFC35977.1  16 MTVYHSQKHEFNLLSHEYEILTFKTSQYDSKIQELD-------QLQDEIKTLKAELNERNEDKKKIRILEAELQKASESLQSQEVLKEAIKDFESELTK 107
                 233444444444444555555555555555555554.......33445666666666556666666666666666677777788888888888888888 PP

         MAD 240 eEkareelvkLelekekleqeLksWeklaqdtgLnlrsPealsrkieqLqqeeivlkee 298
                  E  r e  +Le ++  +e  LksWe+ + +     ++P ++  +i +Lq + i+  ee
  EFC35977.1 108 LEVLRIENSSLESKLYNTESLLKSWESAFPN-----NTPSDVNYNI-KLQAKKITRLEE 160
                 8888888888888888888888888888887.....7788877776.477777776665 PP

  == domain 2  score: 66.9 bits;  conditional E-value: 1.1e-21
         MAD 586 idittnsqyRltSmYaeekedallfklsesnesklkLletpfSrtleelidlhlaeqksiPaflsalTLeLfsrqt 661
                 +d+  n+ +Rl+SmYae++ed+l+f   es +  +kLl+++f+ +lee     l++  siP+fl ++TL+Lf++qt
  EFC35977.1 178 LDVIENNRFRLSSMYAESPEDYLIF---ESDGNAMKLLNSEFACSLEEKSMRFLKNFRSIPGFLCSITLDLFNKQT 250
                 79***********************...666678****************************************98 PP

>> DUF4201  Domain of unknown function (DUF4201)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0  17.4   1.7e-06    0.0018      62     175 ..      12     129 ..       1     131 [. 0.84
   2 ?    0.4   0.1      0.44   4.6e+02     100     121 ..     148     169 ..     138     177 .. 0.63

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.7e-06
     DUF4201  62 nkeLkrlkkkttktvhalthlkeklhmleselselkkelkekeerlaklrkelykvklerdklrkqneklkqqggllrvPaLlk....DYdktkekvee 156
                 n eL    ++ + +   l+h+ e l++ +s++  + +el++++++++ l++el++ +++++k+r   ++l++ ++ l+  ++lk    D++ +  k+e 
  EFC35977.1  12 NSELMTVYHSQKHEFNLLSHEYEILTFKTSQYDSKIQELDQLQDEIKTLKAELNERNEDKKKIRILEAELQKASESLQSQEVLKeaikDFESELTKLEV 110
                 667777777777788889*****************************************************9999888888874333399999999999 PP

     DUF4201 157 krksvkkLrrkvkilemrl 175
                 +r +  +L+ k+ + e+ l
  EFC35977.1 111 LRIENSSLESKLYNTESLL 129
                 9999999999999887655 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.44
     DUF4201 100 lkekeerlaklrkelykvkler 121
                 +k + +++++l++ +++v++e+
  EFC35977.1 148 IKLQAKKITRLEETIQEVNQEK 169
                 5555566666666666666665 PP

>> MerR-DNA-bind  MerR, DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.2   0.00079      0.83      42      64 ..      44      66 ..      31      67 .. 0.86
   2 ?   -0.9   0.6       2.4   2.5e+03      29      59 ..      82     112 ..      73     114 .. 0.66
   3 ?    3.3   0.0      0.11   1.2e+02      23      56 ..     128     166 ..     122     169 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00079
                   HHHHHHHHHHHHHHHHHHHHHHH CS
  MerR-DNA-bind 42 arklaeleeriaeLqalraeLaa 64
                   + k++el++ ++e++ l+aeL++
     EFC35977.1 44 DSKIQELDQLQDEIKTLKAELNE 66
                   57899999999999999999986 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 2.4
                    STTTBHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  MerR-DNA-bind  29 drappcqdvrallarklaeleeriaeLqalr 59 
                    ++a+++ + +++l++ +++ e  + +L+ lr
     EFC35977.1  82 QKASESLQSQEVLKEAIKDFESELTKLEVLR 112
                    4455555566788888888888888887777 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.11
                    HHHHHHS..TTTBHHHHH...HHHHHHHHHHHHHHHHHH CS
  MerR-DNA-bind  23 lLalydd..rappcqdvr...allarklaeleeriaeLq 56 
                    lL  +++  ++ +  dv+   +l a+k+ +lee i+e  
     EFC35977.1 128 LLKSWESafPNNTPSDVNyniKLQAKKITRLEETIQEVN 166
                    666666667777888888888899999999999999865 PP

>> Orthopox_B11R  Orthopoxvirus B11R protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.4         1   1.1e+03      11      35 ..      47      71 ..      40     101 .. 0.60
   2 ?   12.3   0.2    0.0001      0.11       4      31 ..     155     185 ..     152     200 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1
  Orthopox_B11R 11 ineidrekeeilknveie.nnknink 35
                   i+e+d+ ++ei k ++ e n++n +k
     EFC35977.1 47 IQELDQLQDEI-KTLKAElNERNEDK 71
                   77888888777.34444413334333 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 0.0001
  Orthopox_B11R   4 vtnvediineidrekeeilknve...iennk 31 
                    +t +e+ i+e+++ek +i k ve   ienn+
     EFC35977.1 155 ITRLEETIQEVNQEKFDIAKHVEldvIENNR 185
                    899*******************944456664 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   1.2   0.00026      0.28      31      92 ..       5      66 ..       2      69 .. 0.88
   2 ?    8.9   5.3    0.0017       1.8      50      94 ..      65     109 ..      64     118 .. 0.95
   3 ?    0.0   0.2      0.93   9.8e+02      81      96 ..     153     168 ..     133     177 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00026
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N 31 lleldekrrelqveleelqaerNelskeIgkakkkkedaeeliaevkelkeelkaleaelke 92
                  l e+ +   el++   + ++e N ls e + +  k  + ++ i+e ++l++e+k+l+ael+e
    EFC35977.1  5 LEEASTTNSELMTVYHSQKHEFNLLSHEYEILTFKTSQYDSKIQELDQLQDEIKTLKAELNE 66
                  6677777888999999999********99999999999**********************98 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0017
                   HHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  50 aerNelskeIgkakkkkedaeeliaevkelkeelkaleaelkele 94 
                   +erNe  k+I  + ++ ++a+e +++ + lke +k+ e el++le
    EFC35977.1  65 NERNEDKKKIRILEAELQKASESLQSQEVLKEAIKDFESELTKLE 109
                   69****************************************998 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.93
                   HHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  81 eelkaleaelkeleae 96 
                   +++ +le++ +e+++e
    EFC35977.1 153 KKITRLEETIQEVNQE 168
                   3444444444444444 PP

>> HemX  HemX, putative uroporphyrinogen-III C-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   9.0   0.00091      0.96      24     105 ..      37     119 ..      29     134 .. 0.78
   2 ?    2.9   0.1     0.053        56      36     113 ..     114     205 ..     105     211 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00091
        HemX  24 ylgqqqvqeltaevaelqqqlaaleqqlaqveaekeqkqeleerlqqlaeklealekeleqlqkqleel.qqqlskvsgaerk 105
                 +++  q +++ +e ++lq+++++l+++l++ +++k++   le++lq+++e+l+++e ++e+ +   +el + ++ ++++++ +
  EFC35977.1  37 TFKTSQYDSKIQELDQLQDEIKTLKAELNERNEDKKKIRILEAELQKASESLQSQEVLKEAIKDFESELtKLEVLRIENSSLE 119
                 56667777777788****************999999999**************999998887665555414567777766544 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.053
        HemX  36 evaelqqqlaaleqqlaq............veaekeqkqeleerlqqlaeklealekeleql..qkqleelqqqlskvsgaerkdWlLaeAd 113
                 e+++l+++l + e+ l++            v+ + + +++ ++rl+++ +++++ +  +++      +e+++ +ls + +++++d+l+ e d
  EFC35977.1 114 ENSSLESKLYNTESLLKSwesafpnntpsdVNYNIKLQAKKITRLEETIQEVNQEKFDIAKHveLDVIENNRFRLSSMYAESPEDYLIFESD 205
                 55556666666666666666666666666644444444444555555555555555444443114568888899999999999999999877 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   6.5   0.00081      0.85     199     311 ..      48     185 ..      14     246 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00081
       LMBR1 199 deelkklyfeaaklntekeeaerele...dllkevkklrksisesdplrkyleeilk.......................kvPeeiaeklks....... 264
                 + el++l+ e+++l+ e++e +++ +    l  e++k+++s++++    ++l+e +k                       +          +       
  EFC35977.1  48 Q-ELDQLQDEIKTLKAELNERNEDKKkirILEAELQKASESLQSQ----EVLKEAIKdfeseltklevlriensslesklY----------Ntesllks 131
                 3.6666777777777777666655551113334555555555444....56666666444455556555544444444430..........14455555 PP

       LMBR1 265 .......nenkteeslaklekqlikalqkrertekqwkrllekalelediiknk 311
                        n ++  ++ +kl+ + i++l+++ ++ +q k  + k +el  i +n+
  EFC35977.1 132 wesafpnNTPSDVNYNIKLQAKKITRLEETIQEVNQEKFDIAKHVELDVIENNR 185
                 555555333445667777777777777777777777777777777776444443 PP

>> DUF445  Protein of unknown function (DUF445)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1  12.3   0.00097         1     184     322 ..      44     180 ..       6     191 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00097
      DUF445 184 vsmflreltsilekvksdpdhllreeedkkvreliadllndpelaakveklkkkklsdlevqeyeea.....lwealkdlllkdlneeesllreriskl 277
                  s++++  +++ +++k+ +++l +++edkk    i++l+   el++  e l+ + + +++ ++ e++     + +  ++ l+ +l + esll+++ s++
  EFC35977.1  44 DSKIQEL-DQLQDEIKTLKAELNERNEDKK---KIRILEA--ELQKASESLQSQEVLKEAIKDFESEltkleVLRIENSSLESKLYNTESLLKSWESAF 136
                 4555555.9999999988888888888877...5655555..555666666666666666666666622222333334444444444346777777777 PP

      DUF445 278 leklgeklaedpklreklnkflenaaakvlekyrldiskiveetv 322
                  ++  + ++ + kl++k++ +le+ +++v ++ ++di+k+ve  v
  EFC35977.1 137 PNNTPSDVNYNIKLQAKKITRLEETIQEVNQE-KFDIAKHVELDV 180
                 77777788888*****************9999.9*******9655 PP

>> ATG16  Autophagy protein 16 (ATG16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   9.5   0.00022      0.23     101     177 ..       2      74 ..       1      88 [. 0.91
   2 ?    2.4   2.4      0.15   1.6e+02      18      89 ..      95     168 ..      87     177 .. 0.57

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00022
       ATG16 101 aqrllelneelqkleeklkedeerlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnqaEeklrkl 177
                 +++l e++++ ++l +   +++ + + l++e + l+ k ++ + +++e++    +lqDE+ +L+ +ln + e ++k+
  EFC35977.1   2 NKQLEEASTTNSELMTVYHSQKHEFNLLSHEYEILTFKTSQYDSKIQELD----QLQDEIKTLKAELNERNEDKKKI 74 
                 689*********************************************86....68************999988865 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.15
       ATG16  18 aeliqaynrLldrtsaleaenaklekaaasaks..sksskksakekeasasqsnskqsakiqsleqklaqlree 89 
                 +e i+ +   l + + l+ en++le++  +++s  ++++++  + +++  + + + q++ki+ le++++++++e
  EFC35977.1  95 KEAIKDFESELTKLEVLRIENSSLESKLYNTESllKSWESAFPNNTPSDVNYNIKLQAKKITRLEETIQEVNQE 168
                 45555555556666777777777777777777766555444433333333335556666666666666666655 PP

>> PRKG1_interact  cGMP-dependent protein kinase interacting domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  14.5    0.0034       3.5       9      87 ..      46     119 ..       1     127 [. 0.75
   2 ?    3.0   0.1      0.19     2e+02      11      36 ..     153     178 ..     139     232 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0034
  PRKG1_interact   9 ekeenerLkreLeelekelselkseleklkqqrqe..svskrssllelekrerrslerkiseleeelkeleeLraenqrLk 87 
                     + +       eL++l+ e+++lk+el++ ++ +++   ++++ + ++ + ++++ l++ i++ e+el++le Lr en+ L 
      EFC35977.1  46 KIQ-------ELDQLQDEIKTLKAELNERNEDKKKirILEAELQKASESLQSQEVLKEAIKDFESELTKLEVLRIENSSLE 119
                     444.......566666666666666655554433321334444455556677788999999****************9986 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.19
  PRKG1_interact  11 eenerLkreLeelekelselkselek 36 
                     ++  rL ++++e+++e+ ++ +++e 
      EFC35977.1 153 KKITRLEETIQEVNQEKFDIAKHVEL 178
                     44567777777777777766665554 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0  10.9    0.0042       4.4      83     185 ..       8     109 ..       2     200 .. 0.91

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0042
      AAA_11  83 gekykpkivRvgneeeriseavksvsleekvekrlekeekaqlakeiskeleklakelrafeeeeekeklkkskekskskleqerrklkkerkelskel 181
                  ++++ +++ v++++ + + ++ s+  e  + k ++  +k+q  +++++e+++l++el++++e+++k + ++++ +++s+  q+++ lk+++k++++el
  EFC35977.1   8 ASTTNSELMTVYHSQ-KHEFNLLSHEYEILTFKTSQYDSKIQELDQLQDEIKTLKAELNERNEDKKKIRILEAELQKASESLQSQEVLKEAIKDFESEL 105
                 566778899999999.778888888888888888888889999******************99999999999999999999999999999999999999 PP

      AAA_11 182 eeae 185
                 ++ e
  EFC35977.1 106 TKLE 109
                 9876 PP

>> LRRFIP  LRRFIP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   1.4    0.0061       6.4     124     174 ..       3      53 ..       1      59 [. 0.91
   2 ?    4.6  12.5     0.018        19     110     214 ..      65     174 ..      61     187 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0061
      LRRFIP 124 dkleeleeslaelqrelrekckelerlkrqlealkleldelkeklkqrdeL 174
                  +lee   +  el   ++ +  e++ l ++ e+l+++ +++ +k+++ d+L
  EFC35977.1   3 KQLEEASTTNSELMTVYHSQKHEFNLLSHEYEILTFKTSQYDSKIQELDQL 53 
                 57889999999999999999*****************************98 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.018
      LRRFIP 110 NeksallYevdlLkdkleeleeslaelqrelrekckelerlkrqlealkleldelkeklkqrdeLiedhglvlveeeatdge......keeesssssks 202
                 Ne+++ + ++  L  +l++  esl ++q  l+e +k++e++ ++le+l+ e ++l++kl + ++L++       +++ +d++       ++ +  ++++
  EFC35977.1  65 NERNEDKKKIRILEAELQKASESL-QSQEVLKEAIKDFESELTKLEVLRIENSSLESKLYNTESLLKSWESAFPNNTPSDVNyniklqAKKITRLEETI 162
                 899999999999999999999875.899**************************************875545555544444455555444444555555 PP

      LRRFIP 203 alvskeaaelle 214
                 + v +e+ ++ +
  EFC35977.1 163 QEVNQEKFDIAK 174
                 666666655555 PP

>> DASH_Dad4  DASH complex subunit Dad4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.2      0.12   1.3e+02      30      47 ..       1      18 [.       1      32 [. 0.80
   2 ?    7.2   0.6    0.0045       4.8      17      49 ..      47      79 ..      46      91 .. 0.86
   3 ?   -1.9   0.0       3.2   3.3e+03      21      37 ..      92     108 ..      88     120 .. 0.72
   4 ?    3.4   0.3      0.07        74      25      43 ..     153     171 ..     144     193 .. 0.66

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.12
   DASH_Dad4 30 lnkeleeinkkNknvelv 47
                +nk+lee+++ N+++ +v
  EFC35977.1  1 MNKQLEEASTTNSELMTV 18
                899999999999987665 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0045
   DASH_Dad4 17 iknvekLnesvvelnkeleeinkkNknvelvsq 49
                i+ +++L + +++l+ el+e n++ k+++++  
  EFC35977.1 47 IQELDQLQDEIKTLKAELNERNEDKKKIRILEA 79
                67899***********************99865 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 3.2
   DASH_Dad4  21 ekLnesvvelnkeleei 37 
                 e L e+++++++el + 
  EFC35977.1  92 EVLKEAIKDFESELTKL 108
                 55788888888887654 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.07
   DASH_Dad4  25 esvvelnkeleeinkkNkn 43 
                 +++++l+++++e+n++  +
  EFC35977.1 153 KKITRLEETIQEVNQEKFD 171
                 4555566666666555443 PP

>> Allexi_40kDa  Allexivirus 40kDa protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   6.3    0.0015       1.6      65     146 ..      35     117 ..      20     145 .. 0.76
   2 ?    0.2   0.2      0.41   4.4e+02      93     113 ..     151     171 ..     117     195 .. 0.48

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0015
  Allexi_40kDa  65 inklnpvsllsqttlLselrdalrtltklldklksvekklel.saetasdskllkklesietsleelhakldelsssetsese 146
                   i ++ +++  s+ ++L +l+d+++tl+ +l++ ++++kk+++ +ae ++ s+ l++ e++++ +++   +l +l     ++s+
    EFC35977.1  35 ILTFKTSQYDSKIQELDQLQDEIKTLKAELNERNEDKKKIRIlEAELQKASESLQSQEVLKEAIKDFESELTKLEVLRIENSS 117
                   44677777889999999999999999999999999998887515666777888999999999999999998887665555444 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.41
  Allexi_40kDa  93 lldklksvekklelsaetasd 113
                   + +k++++e+++++ +++++d
    EFC35977.1 151 QAKKITRLEETIQEVNQEKFD 171
                   222222222222222222222 PP

>> Cob_adeno_trans  Cobalamin adenosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   3.6      0.03        32      52     105 ..      45     108 ..      10     124 .. 0.58
   2 ?    5.2   0.3     0.019        21      51     102 ..     116     169 ..     101     182 .. 0.67

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.03
                      HHHHHHHHHHHHHHHHHHHHHT.-BTCCG-S--HHHH..........HHHHHHHHHHHHHS--E CS
  Cob_adeno_trans  52 elkeaLeeiqneLfdlgaelatpekkkekkkiteeev..........eelekeideleaelppl 105
                      +  ++L ++q+e+ +l ael   +++k+k +i e+e+          e l ++i+++e+el++l
       EFC35977.1  45 SKIQELDQLQDEIKTLKAELNERNEDKKKIRILEAELqkaseslqsqEVLKEAIKDFESELTKL 108
                      4456778888888888888864433333333333333222222222233445555555555544 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.019
                      HHHHHHHHHHHHHHHHHHHHHHT...-BTCCG-S--HHHHHHHHHHHHHHHHHS CS
  Cob_adeno_trans  51 eelkeaLeeiqneLfdlgaelatp..ekkkekkkiteeeveelekeideleael 102
                      ++l+++L + ++ L +  +++ ++  ++ + + k++++++++le+ i+e+++e 
       EFC35977.1 116 SSLESKLYNTESLLKSWESAFPNNtpSDVNYNIKLQAKKITRLEETIQEVNQEK 169
                      5566666666666666666664334355555667777789********999764 PP

>> Cep57_MT_bd  Centrosome microtubule-binding domain of Cep57
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   4.0     0.034        35       3      67 ..       5      67 ..       3      69 .. 0.76
   2 ?    7.0   1.3    0.0073       7.7      23      58 ..      49      82 ..      47      84 .. 0.66
   3 ?    7.8   1.2    0.0044       4.6       2      30 ..      83     111 ..      82     127 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.034
  Cep57_MT_bd  3 lrpsqspkeaLaevlkeLedEfehlklelqelaaqynaldpslgkrkRkdLaeeleelvkrlEaK 67
                 l+++++ + +L +v +  + Ef  l+ e++ l  +  + d  +  ++ ++L+ e++ l  +l+++
   EFC35977.1  5 LEEASTTNSELMTVYHSQKHEFNLLSHEYEILTFKTSQYD--SKIQELDQLQDEIKTLKAELNER 67
                 5677888888888888888888888888888888888888..77777788888888887777765 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0073
  Cep57_MT_bd 23 EfehlklelqelaaqynaldpslgkrkRkdLaeele 58
                 E+++l+ e ++l a++n+ +   +k+k ++L++el+
   EFC35977.1 49 ELDQLQDEIKTLKAELNERN--EDKKKIRILEAELQ 82
                 66777777777777777776..56666666666665 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0044
  Cep57_MT_bd   2 tlrpsqspkeaLaevlkeLedEfehlkle 30 
                  + ++s +++e+L+e +k  e E+++l + 
   EFC35977.1  83 KASESLQSQEVLKEAIKDFESELTKLEVL 111
                  5799*******************998765 PP

>> Fzo_mitofusin  fzo-like conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   2.9     0.006       6.4     117     154 ..      36      83 ..       8      88 .. 0.59
   2 ?    5.4   2.5     0.012        13     110     159 ..      87     136 ..      71     138 .. 0.75
   3 ?   -0.1   0.1      0.55   5.8e+02     115     139 ..     142     166 ..     137     180 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.006
  Fzo_mitofusin 117 leeeikelekeiekleevqkkakllr..........nkaslleseLek 154
                    l+ ++++ +++i++l+++q + k+l+          +k  +le+eL+k
     EFC35977.1  36 LTFKTSQYDSKIQELDQLQDEIKTLKaelnernedkKKIRILEAELQK 83 
                    455666777777777777777777773333333333555666666665 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.012
  Fzo_mitofusin 110 vdetekeleeeikelekeiekleevqkkakllrnkaslleseLekfeeqy 159
                    + ++++ l+e ik+ e+e++kle +  +   l  k  + es L++ e+ +
     EFC35977.1  87 SLQSQEVLKEAIKDFESELTKLEVLRIENSSLESKLYNTESLLKSWESAF 136
                    33567789999999999999999999999999999998888888877765 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.55
  Fzo_mitofusin 115 keleeeikelekeiekleevqkkak 139
                    ++++ +ik   k+i++lee++++ +
     EFC35977.1 142 SDVNYNIKLQAKKITRLEETIQEVN 166
                    5677777778888888888776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2596  (0.144793); expected 358.6 (0.02)
Passed bias filter:                      728  (0.0406046); expected 358.6 (0.02)
Passed Vit filter:                        94  (0.0052429); expected 17.9 (0.001)
Passed Fwd filter:                        39  (0.00217525); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.92u 0.40s 00:00:01.32 Elapsed: 00:00:00.57
# Mc/sec: 1330.69
//
Query:       EFC35978.1  [L=189]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       925  (0.0515924); expected 358.6 (0.02)
Passed bias filter:                      248  (0.0138323); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1166.44
//
Query:       EFC35979.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.012   16.0   4.0      0.044   14.2   4.0    1.9  1  PPV_E1_N  E1 Protein, N terminal domain


Domain annotation for each model (and alignments):
>> PPV_E1_N  E1 Protein, N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   4.0   2.5e-06     0.044      28     111 ..     247     342 ..     237     350 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.5e-06
    PPV_E1_N  28 aesdeesendsevedLv......Ddasvvqgnslelfqaqeaeesekalqv...LKRKylkSPksr..dvaelSPrLeaislekq.skkakrrLfe 111
                  e dee+en+ +++ L       Dd++++++ns++ f ++e+ e ek+l++   L+  + +   ++  ++ +l  rLe  ++e + + k+  ++f+
  EFC35979.1 247 EEMDEEEENVTSTNYLFavppinDDKDTEKDNSENHFLKKENAELEKKLAEsnrLQNHFASESAKKskEIEDLKMRLEFKTVESNqKSKYLSQIFN 342
                 45677778888888887889999*******************999998865111666776543333469*********999988757777788886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1989  (0.110938); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 2948.51
//
Query:       EFC35980.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      9e-24   83.8   0.1    9.7e-24   83.7   0.1    1.1  1  DSPc           Dual specificity phosphatase, catalytic domain
    2.5e-06   27.3   0.0    2.8e-06   27.1   0.0    1.2  1  Y_phosphatase  Protein-tyrosine phosphatase
     0.0031   17.2   0.1      0.004   16.8   0.1    1.2  1  CDKN3          Cyclin-dependent kinase inhibitor 3 (CDKN3)
  ------ inclusion threshold ------
      0.011   16.0   0.0      0.015   15.6   0.0    1.3  1  Init_tRNA_PT   Rit1 DUSP-like domain


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.7   0.1   2.2e-27   9.7e-24      17     127 ..      37     149 ..      17     152 .] 0.84

  Alignments for each domain:
  == domain 1  score: 83.7 bits;  conditional E-value: 2.2e-27
                 HTCSEEEEESSSSSECECCTTTTSEEEEECCESSTTSCCGGGHHHHHHHHHHH..HHTT-EEEEEESSSSSHHHHHHHHHHHHHHTSCHHHHHH.HHHH CS
        DSPc  17 lgitlvinvtkevpnanalkkseieklripvedehetkiskyleeavefidka..kqkgkkvlVHCqaGisRSatliiaYlmktknlslneaye.flke 112
                 +++t++  +     + +  k+s+ie+ +i+  d    +i+k+ ++  efid+a   +++++vlVHC  G+sRSa++++aYlm +k+++ +eay+  +k+
  EFC35980.1  37 YKFTHICVCGFGLIK-KHEKTSQIEYHHIKAVDLPVYNITKDVKSCAEFIDNAlnGDENNRVLVHCSRGVSRSASIVTAYLMLKKGMTFEEAYYgNVKK 134
                 567777666655554.44599*********9999*******************777799*********************************86379** PP

                 HSTT-SSTHHHHHHH CS
        DSPc 113 rrpaispnagfirqL 127
                 +r+ ++ n gf +qL
  EFC35980.1 135 KRSIVCLNQGFAEQL 149
                 **************9 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.0   6.2e-10   2.8e-06     126     196 ..      52     120 ..      21     140 .. 0.81

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 6.2e-10
                    TTTTEEEEEEEEEEESSS-SSSSGSCCHHHHHHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHHHHHHHH CS
  Y_phosphatase 126 kkeeseerevkqlqytnWpdhgvpesaksllklirkvekskeaksgpvvVhCsaGvgRtgtfvaldillqq 196
                    k e++ + e ++++  + p  ++ ++ ks  ++i+++ +    +++ v+VhCs Gv+R++++v++ ++l++
     EFC35980.1  52 KHEKTSQIEYHHIKAVDLPVYNITKDVKSCAEFIDNALNGD--ENNRVLVHCSRGVSRSASIVTAYLMLKK 120
                    333333556677777777788888999*******9999999..89********************999987 PP

>> CDKN3  Cyclin-dependent kinase inhibitor 3 (CDKN3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1     9e-07     0.004     111     156 ..      73     118 ..      42     127 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 9e-07
                 TS---HHHHHHHHHHHHHHHHTT--EEEE-SSSSSHHH.HHHHHHHH CS
       CDKN3 111 ggtpdiascleimeelatclknyrktlihcygglgrsc.lvaaclll 156
                   t d+ sc e +++     +n+r  l+hc  g+ rs+ +v+a l+l
  EFC35980.1  73 NITKDVKSCAEFIDNALNGDENNR-VLVHCSRGVSRSAsIVTAYLML 118
                 4589*********99888877776.89*********97245555555 PP

>> Init_tRNA_PT  Rit1 DUSP-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.6   0.0   3.2e-06     0.015      16      61 ..      73     118 ..      50     144 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 3.2e-06
  Init_tRNA_PT  16 nLrtalpkivdfvrkrlsedkkkkilvacetGkdlsvgvaLailck 61 
                   n+ + ++++ +f+ + l+ d+++++lv+c  G + s++++ a l+ 
    EFC35980.1  73 NITKDVKSCAEFIDNALNGDENNRVLVHCSRGVSRSASIVTAYLML 118
                   6778899*************************99999999998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       476  (0.0265492); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 900.52
//
Query:       EFC35981.1  [L=163]
Description: hypothetical protein NAEGRDRAFT_76351 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
       0.01   15.7   0.2       0.44   10.5   0.0    2.9  2  HTH_25           Helix-turn-helix domain
  ------ inclusion threshold ------
      0.015   15.2   0.0      0.027   14.3   0.0    1.4  1  F-box-like       F-box-like
       0.04   13.8   0.9      0.062   13.2   0.1    1.7  2  F-box            F-box domain
       0.05   13.0   3.0      0.053   12.9   0.5    1.9  2  Put_Phosphatase  Putative Phosphatase
      0.055   13.8   0.1      0.055   13.8   0.1    2.6  3  PRANC            PRANC domain
       0.12   11.3   0.1       0.17   10.8   0.1    1.4  1  Glyco_hydro_79n  Glycosyl hydrolase family 79, N-terminal dom
        0.3   11.2   3.8       0.21   11.7   1.2    2.1  2  COMM_domain      COMM domain
        3.6    7.6  20.0       0.13   12.3   3.0    2.3  2  CENP-F_leu_zip   Leucine-rich repeats of kinetochore protein 
        3.8    8.0  12.5       0.98    9.9   2.2    3.3  3  FlaC_arch        Flagella accessory protein C (FlaC)
        5.3    6.9  11.4         17    5.2   2.9    2.5  2  SKA2             Spindle and kinetochore-associated protein 2
        6.4    6.6  10.7      2e+02    1.7  10.7    2.0  1  PCRF             PCRF domain


Domain annotation for each model (and alignments):
>> HTH_25  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   0.00027      0.44      38      59 ..      39      60 ..      16      63 .. 0.86
   2 ?    1.9   0.4      0.13   2.1e+02      12      32 ..      65      85 ..      61      89 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00027
                SS-HHHHHHHHHHHHHHTT--H CS
      HTH_25 38 lpepvylrgylrnYArlLgldp 59
                  ++++ r +++nY +lLg d+
  EFC35981.1 39 VQSETFWRTLIKNYSKLLGSDS 60
                4578***************986 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.13
                -HHHHHHHSS--HHHHHHHHC CS
      HTH_25 12 sleevaketkIrkdylealEe 32
                s++e+ +   I+k+ +e +E 
  EFC35981.1 65 SVQELLEIAEIKKKFIELIEM 85
                8899999999*********96 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   1.7e-05     0.027       3      45 ..       6      48 ..       4      50 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.7e-05
  F-box-like  3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrl 45
                +LP E+ ++IFs L+ + L ++    ++ ++       +Wr+l
  EFC35981.1  6 DLPSELQIEIFSNLSVKHLKNILSINKSTHEQLVQSETFWRTL 48
                8******************997777666665554455777776 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   3.8e-05     0.062       2      25 ..       3      26 ..       2      36 .. 0.84
   2 ?   -3.0   0.0       4.4   7.2e+03      33      39 ..      45      51 ..      43      54 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.8e-05
                HHHHS-HHHHHHHHHTS-HHHHHH CS
       F-box  2 tlsrLPsevlrhILerLplsdlla 25
                ++ +LPse+  +I+++L+ ++l +
  EFC35981.1  3 NFVDLPSELQIEIFSNLSVKHLKN 26
                5779**************999755 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.4
                HHHHHTT CS
       F-box 33 wrilids 39
                wr li++
  EFC35981.1 45 WRTLIKN 51
                9999986 PP

>> Put_Phosphatase  Putative Phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.5   3.3e-05     0.053      29      92 ..      34      95 ..      13      99 .. 0.81
   2 ?    0.5   0.1       0.2   3.2e+02      42      71 ..     132     161 ..     108     163 .] 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.3e-05
  Put_Phosphatase 29 lfeelretlrkglwnelmdrvlkelheqgvseadikkvlrsiplspglvelikslakkkleldl 92
                     + e+l ++  +++w +l+++  k l+++ + e+++++ l+   ++ +++eli++ +++++e+++
       EFC35981.1 34 THEQLVQS--ETFWRTLIKNYSKLLGSDSRVEKSVQELLEIAEIKKKFIELIEMKKRTTEEFQM 95
                     33444443..47*****************************************99998888876 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.2
  Put_Phosphatase  42 wnelmdrvlkelheqgvseadikkvlrsip 71 
                       n  m+r+ +e ++ ++++++i++ lr++ 
       EFC35981.1 132 LNIGMERMKQECESVKKEKEEIEEKLRKLI 161
                      566699999999999999999999999875 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   3.4e-05     0.055      72      96 ..       4      28 ..       1      29 [. 0.90
   2 ?    0.3   0.5      0.55     9e+02      40      63 ..      61      84 ..      30     106 .. 0.57
   3 ?   -1.9   0.1       2.7   4.5e+03      40      60 ..     138     158 ..     127     161 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 3.4e-05
       PRANC 72 WnlLPiEIkykIleyLndkdLknll 96
                   LP E++++I+++L+ k+Lkn+l
  EFC35981.1  4 FVDLPSELQIEIFSNLSVKHLKNIL 28
                568********************97 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.55
       PRANC 40 likkiiksakkrykliekaievln 63
                +++k+++++ +  ++ +k ie ++
  EFC35981.1 61 RVEKSVQELLEIAEIKKKFIELIE 84
                444444444444444444444444 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2.7
       PRANC  40 likkiiksakkrykliekaie 60 
                 ++k+  +s+kk ++ ie+ ++
  EFC35981.1 138 RMKQECESVKKEKEEIEEKLR 158
                 556666666666666665554 PP

>> Glyco_hydro_79n  Glycosyl hydrolase family 79, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1    0.0001      0.17      54      96 ..     110     152 ..      61     157 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0001
  Glyco_hydro_79n  54 lanaikafsplrirlGGslqdkvvyevgekkkpckefkkkede 96 
                       ++ ++a ++  + lGG++ d++   ++++k++c+++kk+++e
       EFC35981.1 110 AQREMQAGNESVLLLGGTISDQLNIGMERMKQECESVKKEKEE 152
                      45567788888899*************************9887 PP

>> COMM_domain  COMM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   1.2   0.00013      0.21      44      69 ..      91     116 ..      76     118 .. 0.85
   2 ?   -1.7   0.1         2   3.3e+03      56      71 ..     132     147 ..     130     148 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00013
  COMM_domain  44 vtlelskeqLqeLlneLeeiqkqles 69 
                   +++++  +L+ +l eLe +q+++++
   EFC35981.1  91 EEFQMTSLKLKYMLRELEMAQREMQA 116
                  47**********************96 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 2
  COMM_domain  56 LlneLeeiqkqlesla 71 
                  L  ++e+++++ es++
   EFC35981.1 132 LNIGMERMKQECESVK 147
                  5567999999999986 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   9.3      0.23   3.8e+02      69     122 ..      63     116 ..      20     124 .. 0.74
   2 ?   12.3   3.0     8e-05      0.13      42      73 ..     131     162 ..     126     163 .] 0.88

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.23
  CENP-F_leu_zip  69 releldLvalrsekeeLekelqkkqervseLeslnsslenlleekEqekvqmke 122
                     ++  ++L ++ + k++  + ++ k+++ +e +++ ++l+ +l+e+E+ +++m+ 
      EFC35981.1  63 EKSVQELLEIAEIKKKFIELIEMKKRTTEEFQMTSLKLKYMLRELEMAQREMQA 116
                     455567777777788888888888888888888888888888888888888865 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 8e-05
  CENP-F_leu_zip  42 kvileaEtskaevetlkeeieelaeelrelel 73 
                     ++ + +E  k+e+e++k+e+ee++e+lr+l +
      EFC35981.1 131 QLNIGMERMKQECESVKKEKEEIEEKLRKLII 162
                     566789**********************9965 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.4      0.14   2.3e+02      29      45 ..      58      74 ..      35      85 .. 0.69
   2 ?    2.1   0.1      0.16   2.5e+02      14      34 ..     105     125 ..      89     134 .. 0.68
   3 ?    9.9   2.2    0.0006      0.98      12      41 ..     132     161 ..     129     162 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.14
   FlaC_arch 29 sveelkenVkdllsLYE 45
                s  +++++V++ll++ E
  EFC35981.1 58 SDSRVEKSVQELLEIAE 74
                55567777888877654 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.16
   FlaC_arch  14 teletvkkeneelsksveelk 34 
                  ele++++e++  ++sv  l 
  EFC35981.1 105 RELEMAQREMQAGNESVLLLG 125
                 388999999988888876555 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.0006
   FlaC_arch  12 lsteletvkkeneelsksveelkenVkdll 41 
                 l + +e +k+e e+++k+ ee++e+ ++l+
  EFC35981.1 132 LNIGMERMKQECESVKKEKEEIEEKLRKLI 161
                 666788888899999999999998888886 PP

>> SKA2  Spindle and kinetochore-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   2.9     0.011        17      53      93 ..      71     111 ..      50     121 .. 0.85
   2 ?    5.1   5.8     0.011        18      11      79 ..      93     161 ..      93     163 .] 0.79

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.011
        SKA2  53 elqaLkeqceellaekkelidkirttlvanrellqqLqasa 93 
                 e++++k+++ el + kk+++++++ t  + + +l++L+ + 
  EFC35981.1  71 EIAEIKKKFIELIEMKKRTTEEFQMTSLKLKYMLRELEMAQ 111
                 68899*********************99*******999776 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.011
        SKA2  11 FqkaesdLdyvqhrLekefqqsypdnaeNpvkLlerlk.kvkeelqaLkeqceellaekkelidkirttl 79 
                 Fq  + +L+y  + Le+  ++  + n e ++ L   ++ +++  ++ +k++ce + +ek+e+ +k+r+ +
  EFC35981.1  93 FQMTSLKLKYMLRELEMAQREMQAGN-ESVLLLGGTISdQLNIGMERMKQECESVKKEKEEIEEKLRKLI 161
                 55566677888888887666666666.58888888887469999*********************99876 PP

>> PCRF  PCRF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7  10.7      0.12     2e+02      25      89 ..      53     160 ..      28     163 .] 0.39

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.12
                 SSTTHHHHHTHHHHHHHHHHHHHTTTHHH...HT.....-S-..-GG...........................................GTHHHHHHH CS
        PCRF  25 kklskelaeleeivealeeleealedleeakelle.edeelaelaee...........................................eleelekel 79 
                 +kl  + +++e+ v++l e+ e +++  e+ e+ + + ee++ + +                                            e+e+++ke 
  EFC35981.1  53 SKLLGSDSRVEKSVQELLEIAEIKKKFIELIEMKKrTTEEFQ-MTSLklkymlrelemaqremqagnesvlllggtisdqlnigmermkqECESVKKEK 150
                 444444455555555555555555555554333322111221.11111112222111111112222222222222222222222222222566666666 PP

                 HHH..HHHHH CS
        PCRF  80 eeleeelkkl 89 
                 ee+ee+l+kl
  EFC35981.1 151 EEIEEKLRKL 160
                 6666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2157  (0.120308); expected 358.6 (0.02)
Passed bias filter:                      602  (0.0335769); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 1045.92
//
Query:       EFC35982.1  [L=176]
Description: acetyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-15   57.2   0.0    2.2e-15   56.9   0.0    1.2  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    3.9e-12   46.4   0.1    5.4e-12   46.0   0.1    1.3  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
      1e-11   44.9   0.0    1.7e-11   44.2   0.0    1.3  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    1.1e-06   29.4   0.0    1.3e-06   29.1   0.0    1.1  1  Acetyltransf_3   Acetyltransferase (GNAT) domain
      7e-06   26.3   0.2      4e-05   23.8   0.2    2.1  1  Acetyltransf_4   Acetyltransferase (GNAT) domain
    3.7e-05   23.8   0.0    7.8e-05   22.7   0.0    1.5  1  Acetyltransf_CG  GCN5-related N-acetyl-transferase
    6.1e-05   22.6   1.7    0.00018   21.0   1.7    1.9  1  Acetyltransf_15  Putative acetyl-transferase
     0.0003   20.7   0.0    0.00058   19.8   0.0    1.5  1  FR47             FR47-like protein
    0.00049   19.8   0.0    0.00085   19.1   0.0    1.4  1  PanZ             Acetyltransferase (GNAT) domain, PanZ
     0.0023   17.9   0.5     0.0036   17.3   0.5    1.3  1  LRR_5            BspA type Leucine rich repeat region (6 copi
     0.0035   17.4   0.3     0.0091   16.1   0.2    1.7  2  Acetyltransf_9   Acetyltransferase (GNAT) domain
  ------ inclusion threshold ------
      0.018   14.7   0.2      0.048   13.3   0.2    1.7  1  zf-P11           P-11 zinc finger
      0.043   14.0   0.7       0.11   12.6   0.2    1.8  2  Mss4             Mss4 protein
      0.045   13.3   0.1      0.085   12.4   0.1    1.4  1  GNAT_acetyltran  GNAT acetyltransferase
      0.058   13.3   0.0      0.091   12.7   0.0    1.3  1  LppA             Lipoprotein confined to pathogenic Mycobacte
      0.068   12.7   0.0      0.094   12.2   0.0    1.3  1  PNKP_ligase      PNKP adenylyltransferase domain, ligase doma


Domain annotation for each model (and alignments):
>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.9   0.0     2e-18   2.2e-15      33     117 .]      63     152 ..      27     152 .. 0.81

  Alignments for each domain:
  == domain 1  score: 56.9 bits;  conditional E-value: 2e-18
                     CEEEE.EEET.......TEEEEEEEEEEEETTSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHTTESEEEEEEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  33 egllv.aeed.......geliGfisllkipdekggvayieslaVspeyrgkGlGsaLlealeerareegikkivlaveedndaairlYeklGF 117
                     +g+l  +e +        ++i+ ++++k  +    +++++ ++ ++eyrgkGlG++Lle ++e+a+e ++k ++l++ +  + a +lYek+GF
      EFC35982.1  63 NGYLEiVELNsnsssieSKIIASCGIYKLSE---SKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYKQMELETASVLVEALALYEKFGF 152
                     3333334444556666688**********99...9******************************************999************9 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.0   0.1   4.8e-15   5.4e-12      12      75 ..      80     153 ..      55     154 .. 0.67

  Alignments for each domain:
  == domain 1  score: 46.0 bits;  conditional E-value: 4.8e-15
                     TEEEEEEEEEEES...TCTEEEEE-GGGTTSSHHHHHHH.HTT....SEEEEE.EEEETHH....HHHHHHHHTTEE CS
  Acetyltransf_7  12 gkivGfialslld...aeitrlaVdpeyrgkGiGraLle.aae....kgiile.qlelnae....kaikfYeklGFe 75 
                      ki+  ++++ l+   +e+ +++ ++eyrgkG+Gr+Lle a+e       + + q el++     +a+++Yek+GF 
      EFC35982.1  80 SKIIASCGIYKLSeskCELRKMYLREEYRGKGLGRKLLErAIEkakeM--N-YkQMELETAsvlvEALALYEKFGFS 153
                     455544444444455488888*****************9652233231..2.223344221235689*********7 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.2   0.0   1.5e-14   1.7e-11      43     109 ..      86     155 ..      75     166 .. 0.85

  Alignments for each domain:
  == domain 1  score: 44.2 bits;  conditional E-value: 1.5e-14
  Acetyltransf_10  43 vGviel.rdgshisllfVdpeyrgqGigkaLleaveeeaekdgikl.eltvnasp.yavpfYeklGFkav 109
                      +G+ +l +++ ++  ++ ++eyrg+G+g++Lle+++e+a+++++k+ el+  +   +a ++Yek+GF +v
       EFC35982.1  86 CGIYKLsESKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYKQmELETASVLvEALALYEKFGFSRV 155
                      377788555559*********************************88888888889***********988 PP

>> Acetyltransf_3  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.1   0.0   1.2e-09   1.3e-06       3     137 ..      13     152 ..      12     153 .. 0.76

  Alignments for each domain:
  == domain 1  score: 29.1 bits;  conditional E-value: 1.2e-09
  Acetyltransf_3   3 lLrplteeDlealfelrsdpevmry.lpe.pltleeaeewlera....waeeseeegygwaivl..kdtg......viGsvglrdleeedeeael 83 
                     ++r +te+D ++++e+++ + +++y l++ + + ++ ++ l ++    ++    ++gy  +++l  +  +      +i s+g+++l+e+   +el
      EFC35982.1  13 TFRAATEQDGPQILEMVT-QILTKYgLKQiQDPSDNIDDDLLNIekyyFT----NNGYLEIVELnsN--SssieskIIASCGIYKLSESK--CEL 98 
                     789999999999999666.5678897444444444445555555333333....4888777766542..22345537**********996..*** PP

  Acetyltransf_3  84 g.ymlapsfwgkGyateavralleyafeelglerlvavidkeNeaSirvleklGf 137
                       ++l+++++gkG+++  ++ ++e a +e+++++++ +++       +++ek Gf
      EFC35982.1  99 RkMYLREEYRGKGLGRKLLERAIEKA-KEMNYKQMELETASVLVEALALYEKFGF 152
                     94556677******************.9999***********************9 PP

>> Acetyltransf_4  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.2   3.6e-08     4e-05      75     137 ..      93     155 ..      14     162 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 3.6e-08
  Acetyltransf_4  75 dwkael.svylaerdnnkeglgrelidaleqvlkeqnienllaeiaspnensiqfhkalGFelv 137
                     + k+el ++yl  +  + +glgr+l++  ++ +ke+n+++++ e+as   ++ ++++++GF+ v
      EFC35982.1  93 ESKCELrKMYLR-EEYRGKGLGRKLLERAIEKAKEMNYKQMELETASVLVEALALYEKFGFSRV 155
                     4666664799*5.89**********************************************976 PP

>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   6.9e-08   7.8e-05      17      59 ..      89     130 ..      74     132 .. 0.87

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 6.9e-08
  Acetyltransf_CG  17 YevrkegvldfthTeVpeelrGkGiAkkLvkaalddareeglk 59 
                      Y+   e + ++ + +  ee+rGkG+++kL ++a+++a+e ++k
       EFC35982.1  89 YK-LSESKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYK 130
                      55.6677999999**************************9986 PP

>> Acetyltransf_15  Putative acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   1.7   1.6e-07   0.00018      32     107 ..      61     131 ..      26     174 .. 0.73

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.6e-07
  Acetyltransf_15  32 knenkydivqykkkeeLvasvfivkkkyyslvssilieknvleiYtlyvsekyrgkGlakklLeeslkelkkn.Ykv 107
                       n+ + +iv+ + +   + s  i  +  y+l++s        e+ ++y  e+yrgkGl +klLe+++++ k + Yk 
       EFC35982.1  61 TNNGYLEIVELNSNSSSIESKIIASCGIYKLSES------KCELRKMYLREEYRGKGLGRKLLERAIEKAKEMnYKQ 131
                      3334557777777777777777777777777763......3477789*******************99987542544 PP

>> FR47  FR47-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.0   5.2e-07   0.00058      21      80 ..      95     155 ..      79     160 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 5.2e-07
                 TSSEEEEEE-GGG-SSSHHHHHHHHHHHHHHH.S-S-EEEEEETT-HHHHHHHHHHT-EEE CS
        FR47  21 ggelgalqvlpehrrrGlgsrlvkalakeiae.rgktvllvvvasNtpsirlyeklGfeki 80 
                   el  +++++e r++Glg++l +  +++  e + k++ l ++    ++ +lyek Gf   
  EFC35982.1  95 KCELRKMYLREEYRGKGLGRKLLERAIEKAKEmNYKQMELETASVLVEALALYEKFGFSRV 155
                 578999*****************999999999667777788888899***********865 PP

>> PanZ  Acetyltransferase (GNAT) domain, PanZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   7.6e-07   0.00085      56     105 ..      90     139 ..      75     157 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 7.6e-07
        PanZ  56 eledkeaelsdlcVRevTRrRGVgsyLleearrqaPevkswvlaeedvke 105
                 +l++++ el+++  Re+ R +G g++Lle+a ++a e++  ++  e+ + 
  EFC35982.1  90 KLSESKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYKQMELETASV 139
                 56778899***************************999999988887554 PP

>> LRR_5  BspA type Leucine rich repeat region (6 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.5   3.2e-06    0.0036      63     107 ..      47      91 ..      30     102 .. 0.83

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.2e-06
       LRR_5  63 tipssltsigeyaFsncsslkeitlpsnlttigssaFsncslesi 107
                 +i ++l +i++y F+n+  l+ ++l+sn ++i+s+++++c + ++
  EFC35982.1  47 NIDDDLLNIEKYYFTNNGYLEIVELNSNSSSIESKIIASCGIYKL 91 
                 577788889999999999999999999999999999988887765 PP

>> Acetyltransf_9  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       3.7   4.1e+03       2      18 ..      14      30 ..      13      37 .. 0.82
   2 !   16.1   0.2   8.1e-06    0.0091      83     126 ..     105     153 ..     101     155 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 3.7
                    EEEE-GGGHHHHHHHHH CS
  Acetyltransf_9  2 irelteedldevlellk 18
                    +r +te+d +++le++ 
      EFC35982.1 14 FRAATEQDGPQILEMVT 30
                    68999999999999876 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 8.1e-06
                     CCGTTS-HHHHHHHHHHHHHHHTT--EEEE--SSH.....HHHHTTT-E CS
  Acetyltransf_9  83 pehrgrgvlskLlaraleemreegqplsllfPssi.....piYrrfGye 126
                      e+rg+g+ +kLl+ra+e+++e++++   l  +s+     ++Y++fG++
      EFC35982.1 105 EEYRGKGLGRKLLERAIEKAKEMNYKQMELETASVlvealALYEKFGFS 153
                     69*********************998887777555555569******97 PP

>> zf-P11  P-11 zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.2   4.2e-05     0.048      12      33 ..     152     173 ..     149     174 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 4.2e-05
                 -SSEEE-SSSEEEHHHHHHHHH CS
      zf-P11  12 dksLveCsdHYLClrClqllLs 33 
                 +  ++ C+d  LC rC  ++++
  EFC35982.1 152 FSRVIDCEDKHLCSRCDIIMIK 173
                 6779*************99975 PP

>> Mss4  Mss4 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       1.5   1.7e+03      33      54 ..      51      65 ..      20      96 .. 0.58
   2 ?   12.6   0.2    0.0001      0.11      24      71 ..     122     169 ..     103     172 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.5
        Mss4 33 eselleefllvedvfdFdnvgv 54
                +  ++e++++ ++       g+
  EFC35982.1 51 DLLNIEKYYFTNN-------GY 65
                2233444444443.......33 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 0.0001
        Mss4  24 kksekeeqkeselleefllvedvfdFdnvgvskevesskyLiCAdCek 71 
                 +k ++++ k++el+++ +lve    ++  g+s+ ++  +  +C+ C++
  EFC35982.1 122 EKAKEMNYKQMELETASVLVEALALYEKFGFSRVIDCEDKHLCSRCDI 169
                 23567788899999***********************99999****96 PP

>> GNAT_acetyltran  GNAT acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   7.5e-05     0.085     165     236 ..      79     154 ..      75     157 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 7.5e-05
  GNAT_acetyltran 165 ngeivsgasSysvyekgiei.eidTkedyrrkgLAtivaaalileclkrgly.PsWDaa..neaSvaLaekLGYef 236
                      +++i++ +  y  +e++ e  +   +e+yr+kgL +++ ++ i+++ + ++   +  +a    +++aL+ek+G+ +
       EFC35982.1  79 ESKIIASCGIYKLSESKCELrKMYLREEYRGKGLGRKLLERAIEKAKEMNYKqMELETAsvLVEALALYEKFGFSR 154
                      6789999999999999999844777*********************997754167888877788999999999975 PP

>> LppA  Lipoprotein confined to pathogenic Mycobacterium
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   8.2e-05     0.091      85     120 ..      15      50 ..       6      64 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 8.2e-05
                 S---HHHHHHHHHHHHHHHHTTT--EEE-S-BSSS- CS
        LppA  85 gpipddqWpqaleiVrelAakygatevevfkDepgd 120
                  + ++++ pq+le+V+++  kyg+++++   D+ +d
  EFC35982.1  15 RAATEQDGPQILEMVTQILTKYGLKQIQDPSDNIDD 50 
                 5789***********************998887665 PP

>> PNKP_ligase  PNKP adenylyltransferase domain, ligase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   8.4e-05     0.094      40      71 ..     142     174 ..     126     176 .] 0.91

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 8.4e-05
                  HHHHHHHTTT--EEE.EEEE-SSEEEEEEEESS CS
  PNKP_ligase  40 eafeayrkegveevv.ceekHmGsRavvlvcrd 71 
                  ea++ y+k g ++v+ ce+kH+ sR  +++++d
   EFC35982.1 142 EALALYEKFGFSRVIdCEDKHLCSRCDIIMIKD 174
                  89************99**********9999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       714  (0.0398237); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.48u 0.33s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1135.39
//
Query:       EFC35983.1  [L=260]
Description: cell cycle dependent kinase C, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-06   28.2   0.0    1.9e-06   27.5   0.0    1.4  1  Pkinase     Protein kinase domain
  ------ inclusion threshold ------
      0.095   11.9  17.5        0.1   11.8  17.5    1.1  1  SOG2        RAM signalling pathway protein


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.0   2.1e-10   1.9e-06     209     264 .]      16      98 ..       6      98 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 2.1e-10
                 HHHTHHHHHHHCT.SHH...HHHTTS..........................-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 209 eldqlekilkilg.etkeklpeasei..........................seeakdllkkllkkdpkkRltaeellqhpyl 264
                 +++qleki++  g +++e+++e +++                          s++++dll+kll  +p kRlt +e+l+h+++
  EFC35983.1  16 DVNQLEKIFEWCGtPSTEEWAEVENLahwnalkpkeskkrrllerfanlkscSKKVLDLLDKLLVLNPAKRLTTNECLNHDWF 98 
                 5666666666666666666666666677777788888888888888888888******************************8 PP

>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8  17.5   1.1e-05       0.1     222     339 ..     130     253 ..      37     259 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.1e-05
        SOG2 222 dveqGaalt.plrsdqipfnl....srsrrssssgnsaspaangaqsetsersasssg.vqssasstPlgegstspp.galsrqslsttgststltsss 313
                   +++ +l+ + +++q+p+n      +s++sss+       + + +s+ + +s + s   qss++s+  +++s+s++ g++ ++s+  ++s++ ++sss
  EFC35983.1 130 PNAPSHQLPgSTSVQQLPHNInqsyGVSSTSSSH-------PPFGSSNGNRHSYNPSHhHQSSHHSSHHSNTSSSHHnGSSHHNSHHHHQSSHHHSSSS 221
                 3445556663333447777554443333333333.......3333333333333333334445555455566666655555556555555555555555 PP

        SOG2 314 ksrs.....ssrsnt....nasastprslattpap 339
                  + s     s+   +    n ++ +p+  +++ ap
  EFC35983.1 222 HHGStgsghSN---NyhrdNRHHHDPPQRNNQLAP 253
                 55556654322...123455555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1434  (0.0799822); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 1573.04
//
Query:       EFC35984.1  [L=490]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      5e-10   39.3   0.4      5e-10   39.3   0.4    3.5  3  DSPc           Dual specificity phosphatase, catalytic domain
    0.00038   20.1   0.4     0.0012   18.4   0.0    2.1  2  Y_phosphatase  Protein-tyrosine phosphatase


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.6   6.3         2   1.8e+04      14      63 ..     141     184 ..     109     189 .. 0.57
   2 !   39.3   0.4   5.6e-14     5e-10      41     115 ..     270     350 ..     232     369 .. 0.65
   3 ?    0.2   2.0     0.066   5.9e+02      12      61 ..     409     468 ..     401     474 .. 0.58

  Alignments for each domain:
  == domain 1  score: -4.6 bits;  conditional E-value: 2
                 HHHHTCSEEEEESSSSSECECCTTTTSEEEEECCESSTTSCCGGGHHHHH CS
        DSPc  14 lsklgitlvinvtkevpnanalkkseieklripvedehetkiskyleeav 63 
                 +++++++ ++n     +     ++ ++++l+  +++++++ i++y+++++
  EFC35984.1 141 TNNNNLDNNLNNN--LN----NNNLDNNNLDNNLNNSSQNVIRNYFSNSK 184
                 3333333333322..22....23334555555556666666666666655 PP

  == domain 2  score: 39.3 bits;  conditional E-value: 5.6e-14
                 EEEEECCES....STTSCCGGGHHHHHHHHHHH..HHTT-EEEEEESSSSSHHHHHHHHHHHHHHTS.CHHHHHHHHHHHS.T CS
        DSPc  41 eklripved....ehetkiskyleeavefidka..kqkgkkvlVHCqaGisRSatliiaYlmktknl.slneayeflkerr.p 115
                 ++++  ++d     + + ++++++ +v+ id     +  k +l+HC++G++R++ +i+ Yl+k+k + ++++a+e++k  r  
  EFC35984.1 270 YYMN--IHDlnknLNVKLFTEQMDTIVNDIDLYisNNPTKYILIHCTHGLNRTGFVICYYLLKKKIIeNVEKAIEIFKIHRmT 350
                 2333..44442222333445566666666665544556689************************9999********998842 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.066
                 HHHHHHTCSEEEEESSSSSEC........ECCTTTTSEEEEECCES..STTSCCGGGHHH CS
        DSPc  12 allsklgitlvinvtkevpna........nalkkseieklripved..ehetkiskylee 61 
                 ++ + ++i   in+ ++++n+        n+  ++e  k++i  +d  +++t +s++l++
  EFC35984.1 409 ECFKHYHILKSINLLNKNDNNddnkddnnNDNDNEEEMKKNISKSDndDSSTRLSDDLDS 468
                 467777888888888888877665555543333333334444433333666666666665 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.4      0.32   2.9e+03     122     129 ..     125     132 ..      84     190 .. 0.56
   2 !   18.4   0.0   1.4e-07    0.0012     167     213 ..     303     351 ..     253     355 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.32
                    EEEETTTT CS
  Y_phosphatase 122 evkkkkee 129
                    + ++++++
     EFC35984.1 125 NTTNDNNN 132
                    22222222 PP

  == domain 2  score: 18.4 bits;  conditional E-value: 1.4e-07
                    STTSS-EEEECSSSSHHHHHHHHHHHHHHHHHHHSE..EEHHHHHHHHH CS
  Y_phosphatase 167 eaksgpvvVhCsaGvgRtgtfvaldillqqleaeee..vdvlqivkelr 213
                    ++ ++ +++hC +G +Rtg +++  +l +++ ++ e  +++++i ++ r
     EFC35984.1 303 NNPTKYILIHCTHGLNRTGFVICYYLLKKKIIENVEkaIEIFKIHRMTR 351
                    5678889******************999999994444599999988877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (490 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2738  (0.152713); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.24s 00:00:00.85 Elapsed: 00:00:00.40
# Mc/sec: 3637.49
//
Query:       EFC35985.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.6  13.5        2.3    8.5   0.2    2.5  2  DUF4064   Protein of unknown function (DUF4064)
       0.21   11.3   0.1       0.21   11.3   0.1    2.6  3  DUF5381   Family of unknown function (DUF5381)
        1.5    7.8  15.8       0.14   11.2  10.8    1.7  2  DuoxA     Dual oxidase maturation factor
        7.5    5.2  12.7         31    3.2  12.7    1.8  1  DUF2207   Predicted membrane protein (DUF2207)


Domain annotation for each model (and alignments):
>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.2   0.00051       2.3      30      82 ..      73     127 ..      65     132 .. 0.66
   2 ?    6.3   9.0    0.0026        12      56     100 ..     130     175 ..     127     180 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00051
     DUF4064  30 lssgefsqeltee..qalsgedasavleflstllivlgvialiaivlgivgalll 82 
                 ++s++++ +++e+  ++l  +++ + l  ++ l+ +l+++a++ ++ giv a+++
  EFC35985.1  73 NNSNQEQVNNEETcdNNLVNQEHVYRLNAIFLLIGYLILLAIFEGLCGIVMAFKI 127
                 3333333333333886666666666666666777788889999999999999987 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0026
     DUF4064  56 flstllivlgvialiaivlgivgalllkknkk.vsGilfiiaails 100
                 +  +++i ++++ li+++++i  + ++kk kk ++ i+ ii+  +s
  EFC35985.1 130 ISRGYFICITIAYLITSFAFITILCMIKKEKKwLGFIIQIIIMFVS 175
                 66789999************************66656666655554 PP

>> DUF5381  Family of unknown function (DUF5381)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   4.7e-05      0.21      64     114 ..      12      62 ..       1      74 [. 0.82
   2 ?   -1.4  12.4      0.37   1.7e+03       8      64 ..     102     157 ..      95     171 .. 0.85
   3 ?   -3.7   9.1       1.9   8.7e+03       9      57 ..     129     179 ..     123     192 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 4.7e-05
     DUF5381  64 pallkkGkvlftikeGenGkvisrkksvpikdIkdiklerkslklkgllle 114
                 p ++   k+l+ ike +nGk +s+++++++k+  ++kl+++   +k  l++
  EFC35985.1  12 PKITLGEKLLLWIKEKKNGKKKSNQEMITFKETISVKLRKHLHTIKQTLFN 62 
                 555553489999**************************9888877766665 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.37
     DUF5381   8 rkflrvllflatvglglaglfllfeglkfeskysllyiiigiigtifgliillmvlp 64 
                 +++l ++l+l ++  gl g+++ f+++ ++   +++ i+i+ + t f +i++l +++
  EFC35985.1 102 IFLLIGYLILLAIFEGLCGIVMAFKIISISR-GYFICITIAYLITSFAFITILCMIK 157
                 5566788899999999***********9865.5699****************99876 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 1.9
     DUF5381   9 kflrvllflatvglglagl..fllfeglkfeskysllyiiigiigtifgli 57 
                  + r++ + +t+  +++++   ++   +k e k   + i i i+++ f++i
  EFC35985.1 129 SISRGYFICITIAYLITSFafITILCMIKKEKKWLGFIIQIIIMFVSFCVI 179
                 455556666666555555410344555666666666666666777777765 PP

>> DuoxA  Dual oxidase maturation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0      0.82   3.7e+03     110     130 ..      33      53 ..      26      63 .. 0.70
   2 ?   11.2  10.8   3.1e-05      0.14      15      70 ..     135     190 ..     126     196 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.82
       DuoxA 110 sqlnetidYNErfswslaeel 130
                 ++ +e i + E++s +l+++l
  EFC35985.1  33 KSNQEMITFKETISVKLRKHL 53 
                 456788888888888766655 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 3.1e-05
       DuoxA  15 liiiilvflilavsfllilPGirgkerlftlvrvllslfigavilvvnfgseWeva 70 
                 +i i ++ li+ ++f+ il  i+++++++ ++  ++ +f+   ++v  f++ W v 
  EFC35985.1 135 FICITIAYLITSFAFITILCMIKKEKKWLGFIIQIIIMFVSFCVIVGSFTYVWIVF 190
                 57889999*********************************************875 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2  12.7    0.0068        31     312     409 ..      29     161 ..       8     194 .. 0.60

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.0068
     DUF2207 312 deeldpyEkalldlLfdkseeg.kslkeikkyakkskkkakkfkkalkkwksavkkkergyfdkkg..kkklkklsalglgliilglilillallllvl 407
                 +++ +++ ++ + +  + s +  k+l +ik+++ +sk +  ++  + ++ +++v++  ++  d++   +++ ++l+a+ l+++ l+l++i+ +l+++v+
  EFC35985.1  29 NGK-KKSNQEMITFKETISVKLrKHLHTIKQTLFNSK-LDMSYTPQNNSNQEQVNN--EETCDNNLvnQEHVYRLNAIFLLIGYLILLAIFEGLCGIVM 123
                 111.444444444444444444444777888888877.999999999999999999..55555553335667777777777777777777777777666 PP

     DUF2207 408 l....................................l 409
                 +                                     
  EFC35985.1 124 AfkiisisrgyficitiaylitsfafitilcmikkekK 161
                 68888988777555544444444444444444444432 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1999  (0.111495); expected 358.6 (0.02)
Passed bias filter:                      594  (0.0331307); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1213.78
//
Query:       EFC35986.1  [L=114]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       399  (0.0222544); expected 358.6 (0.02)
Passed bias filter:                      251  (0.0139997); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 679.31
//
Query:       EFC35987.1  [L=132]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       404  (0.0225333); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 809.85
//
Query:       EFC35988.1  [L=793]
Description: kinesin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   5.2e-107  357.6   1.0   5.2e-107  357.6   1.0    2.8  3  Kinesin      Kinesin motor domain
    5.4e-21   75.1   1.2    5.4e-21   75.1   1.2    3.9  4  Microtub_bd  Microtubule binding


Domain annotation for each model (and alignments):
>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.8     0.092   8.2e+02      18      72 ..      15      69 ..       3      81 .. 0.63
   2 ?   -4.1   4.8      0.63   5.7e+03     122     212 ..     158     251 ..     145     262 .. 0.58
   3 !  357.6   1.0  5.7e-111  5.2e-107       1     331 [.     250     581 ..     250     582 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.092
                EEEECTCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHT CS
     Kinesin 18 veveeekkeeekkskkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvle 72
                 ++++ +++++ +++ ++ +  +++ ++  ++d++a +++v + t  +  ++ ++
  EFC35988.1 15 PNTNNMNTTNNMTNNPQQINYMQQQQQYMMMMDPNAMNQTVTSPTLLQQQQQYMN 69
                3333345666777777777777788888888888888888777665555555554 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 0.63
                 EEEEEEEEEEEEEETTEEEETTSTTTTSTSS.EBEEEECTTSCCEEETTS--EEESSHHHHHHHH...HHHHHHHTSTTSSCTSHHCCSEEEEEE CS
     Kinesin 122 ekefsvkvsylEiYneeiyDLLeskkskkkk.klkiredskkgevyvkgltevevksaeevlell...ekgeknrkvaetklneeSSRSHavfti 212
                 +++ +++ + +   n +   LL++ +++    + +i +++  ++++ ++ t++  +sa++  + l    + ++n ++ +t+ n++  R   v+++
  EFC35988.1 158 HSTSQLSAQNINTINTKTKTLLNNPNTSIIGnNPTISNNTV-SNTTANNATSTAATSASNNNNSLvssTSTNTNTNTTTTTSNNNTTRVKVVVRV 251
                 55666777777777888888888776333221223333333.34666666666666665555444111344556666777778777777777666 PP

  == domain 3  score: 357.6 bits;  conditional E-value: 5.7e-111
                 EE-SSSHHHHTTTTEBCEEEECTCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHTTSEEEEEEEESTTSSHHHHHTBC.... CS
     Kinesin   1 RvRplnekekeeeeeeeveveeekkeeekkskkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvleGynatifaYGqtgsGKTyTmegk.... 95 
                 RvRp  +++ ++++     +    ++ +++   +++   +++f+Fdkv++++++q+e+y+++ k++v++vl+Gyn+t++aYGqtgsGKT+T+ g+    
  EFC35988.1 250 RVRPQVSEDISNSQIFGE-YPPCVATVKNTVILKRECYDDREFTFDKVLEPTCSQDEMYKQVGKNIVNDVLKGYNGTVLAYGQTGSGKTFTIFGSstdp 347
                 778877766665555444.444667777777888888999*********************************************************** PP

                 ..........TTTSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEEEEEETTEEEETTSTTTTSTSSEBEEEECTTSCCEEETTS--EEESSHHHHHHH CS
     Kinesin  96 ..........eeeeeGiipraleelFesikkekeekekefsvkvsylEiYneeiyDLLeskkskkkkklkiredskkgevyvkgltevevksaeevlel 184
                            ++ +G+ipr+++++Fe++++ +++  +ef+v vs+++iY+e+i+DLL+ +    k++l ired+k+g v+v++lt+v+v++  ev++l
  EFC35988.1 348 kriikpneniIDKYSGVIPRCINQIFEHVQEYSNN--TEFRVFVSFMQIYMENIMDLLDAS----KTNLPIREDPKNG-VFVEQLTQVQVNEPYEVMQL 439
                 *******99977889***************99987..99********************98....456********98.******************** PP

                 HHHHHHHHTSTTSSCTSHHCCSEEEEEEEEEEEETTTTTCEEEEEEEEEEEEEEECCCHHHHSSTCHHHHHHHHHHHHHHHHHHHHHHHHHHTCCTSTS CS
     Kinesin 185 lekgeknrkvaetklneeSSRSHavftitleqknlkeeteekvkisklnLvDLAGsErasktgaaegerlkEaaniNkSLlaLgrvisaLaekkkskhi 283
                 +++g+knr+v++t++n+ SSRSH +++it+eqk+++++   +vk++ l++vDLAGsEr+ k+g +eg+rl+Ea++iNkSL+aLg++++aL+e+ +  h+
  EFC35988.1 440 IKEGSKNRQVNSTNMNKLSSRSHVILMITVEQKSSSDK---SVKRGVLHIVDLAGSERVFKSG-SEGQRLEEAKKINKSLSALGNCVAALTEE-NVYHV 533
                 *********************************96643...479*******************.58***************************.99*** PP

                 CGGGSHHHHHTGGGHSSSSEEEEEEEE-TBGGGHHHHHHHHHHHHHHC CS
     Kinesin 284 pYRdSkLTrlLqdsLgGnsktlmivtvspssenleetlstlkfaerak 331
                 p+RdSkLTrlL dsLgGn+kt++++t+ ps  n++e++stl+fa+ra 
  EFC35988.1 534 PFRDSKLTRLLTDSLGGNAKTCLVATIGPSMWNYDESYSTLHFANRAM 581
                 **********************************************97 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.7       0.4   3.5e+03      47      78 ..      39      71 ..       9     119 .. 0.60
   2 ?   -2.2   1.7       0.4   3.6e+03      70      94 ..     111     135 ..      56     186 .. 0.65
   3 ?   -2.6   2.2      0.53   4.8e+03      73      94 ..     114     135 ..      90     237 .. 0.59
   4 !   75.1   1.2     6e-25   5.4e-21      22     149 .]     245     403 ..     232     403 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.4
                 TTTEEEE-S.EEEECTTHCCCCCCCCHHHHHHH CS
  Microtub_bd 47 kkkkefsFd.rvfeseseqeevfeeisqlvqsa 78
                 ++++    d   ++++ ++  + ++ +q++++ 
   EFC35988.1 39 QQQYMMMMDpNAMNQTVTSPTLLQQQQQYMNMI 71
                 333333333123333335555555555555554 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.4
                  CCHHHHHHHHTT--EEEEEEES... CS
  Microtub_bd  70 eisqlvqsaldgynvcifaygqTGs 94 
                   is l qs + g+n ++ ++++T s
   EFC35988.1 111 SISNLPQSNMIGSNNNVTTTSTTKS 135
                  4566777777777777777777543 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.53
                  HHHHHHHTT--EEEEEEES... CS
  Microtub_bd  73 qlvqsaldgynvcifaygqTGs 94 
                   l qs + g+n ++ ++++T s
   EFC35988.1 114 NLPQSNMIGSNNNVTTTSTTKS 135
                  4555555555555555555322 PP

  == domain 4  score: 75.1 bits;  conditional E-value: 6e-25
                  -EEEEEEECCCS-T............EEEETTT.............TTTEEEE-SEEEECTTHCCCCCCCC.HHHHHHHHTT--EEEEEEES...... CS
  Microtub_bd  22 iRvfarvrpelesek...........akikfpe..........eekkkkkefsFdrvfeseseqeevfeei.sqlvqsaldgynvcifaygqTGsGKt 97 
                  + v +rvrp+ +++            +                +e   ++ef+Fd+v+e++++q+e+++++ + +v+ +l+gyn +++aygqTGsGKt
   EFC35988.1 245 VKVVVRVRPQVSEDIsnsqifgeyppC-----VatvkntvilkRECYDDREFTFDKVLEPTCSQDEMYKQVgKNIVNDVLKGYNGTVLAYGQTGSGKT 337
                  455555555555533333355555542.....03333466676778999*************99999999857899********************** PP

                  .........................ST-HCHHHHHHHHHHCCTSCCCCEEEEEEEEEEESS-EEETT CS
  Microtub_bd  98 yTmeg...............eeeeagmipraveeifetiselkekgwkyeielqfveiynekvqDlL 149
                  +T+ g                ++ +g+ipr +++ife ++e  +++ ++++ ++f++iy e++ DlL
   EFC35988.1 338 FTIFGsstdpkriikpneniIDKYSGVIPRCINQIFEHVQEY-SNNTEFRVFVSFMQIYMENIMDLL 403
                  ***9999999999988765556779****************9.79*********************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (793 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2708  (0.15104); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.04u 0.34s 00:00:01.38 Elapsed: 00:00:00.56
# Mc/sec: 4278.59
//
Query:       EFC35989.1  [L=953]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   5.7e-106  352.6   0.9   1.1e-105  351.7   0.9    1.5  1  MCM              MCM P-loop domain
    1.9e-39  134.4   0.2    4.5e-39  133.2   0.2    1.6  1  MCM_OB           MCM OB domain
    3.4e-27   94.7   2.0    1.2e-26   93.0   2.0    2.0  1  MCM_lid          MCM AAA-lid domain
    1.9e-07   30.7   0.0    5.8e-06   25.8   0.0    2.5  2  Mg_chelatase     Magnesium chelatase, subunit ChlI
    1.2e-05   25.9   0.1    1.2e-05   25.9   0.1    2.7  2  MCM_N            MCM N-terminal domain
     0.0001   22.2   0.0    0.00027   20.8   0.0    1.6  1  AAA_3            ATPase family associated with various cellul
    0.00056   19.9   0.0     0.0015   18.5   0.0    1.8  1  AAA_5            AAA domain (dynein-related subfamily)
     0.0017   18.0   0.3     0.0049   16.6   0.0    1.9  2  Sigma54_activat  Sigma-54 interaction domain


Domain annotation for each model (and alignments):
>> MCM  MCM P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  351.7   0.9    5e-109  1.1e-105       2     224 .]     408     630 ..     407     630 .. 0.99

  Alignments for each domain:
  == domain 1  score: 351.7 bits;  conditional E-value: 5e-109
                 HHHHHHHHTSSTHHHHHHHHSSTTSSS-HHHHHHHHHHHH---EBBBSSSSBBCSS-EEEEEESSTSTHHHHHHHHHHHSSSEEEEESSSSSSSHSSSE CS
         MCM   2 veeikelakekdiieklvksiapsiyghedvkkaillqlfggvkkkledktklrgdinvllvgdpgtaKsqlLkyveklapravytsgkgssaagLtaa 100
                  e+i +++k++di+e+l++s++psi+gh+++kk+ill+lfggv+k++e+k+++rgdin+++vgdp+taKsq+Lk+v++l+pravytsgk+ssaagLta+
  EFC35989.1 408 HEKILKMSKDEDIYENLASSLCPSIFGHKNIKKGILLMLFGGVHKETEEKIQIRGDINICIVGDPSTAKSQFLKFVSHLIPRAVYTSGKASSAAGLTAS 506
                 689************************************************************************************************ PP

                 EEEESSSSSEEEEETHHHHTTTSEEEEESGGGSTCHHHHHHHHHHHHSEEEEESSSCEEEEE--EEEEEEE--SSSSCCTTS-HHHHSSSSHHHHHHSS CS
         MCM 101 vvrdeetgefvleaGalvladkGvcciDefdkmkeedrsalhEamEqqtisiaKaGivatLnartsvlaAanpkagrydkkksvaeninlsaalLsrFD 199
                 vv+d+e gef++eaGal+lad+GvcciDefdkm+ +d++a+hEamEqqtisiaKaGi atLnar+s+laAanp++gry+++k+++ n+ +++a++srFD
  EFC35989.1 507 VVKDSERGEFTIEAGALMLADNGVCCIDEFDKMDVKDQVAIHEAMEQQTISIAKAGIRATLNARASILAAANPIGGRYNPRKTLKANLGITPAIMSRFD 605
                 *************************************************************************************************** PP

                 EEEEE-SSTTHHHHHHHHHHHHHHH CS
         MCM 200 lifvllDkvdeekDeelaehivslh 224
                 l+fv++D++d+e D+++aehivs+h
  EFC35989.1 606 LFFVVQDECDAEIDKKIAEHIVSVH 630
                 **********************987 PP

>> MCM_OB  MCM OB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.2   0.2     2e-42   4.5e-39       1     125 [.     169     298 ..     169     299 .. 0.96

  Alignments for each domain:
  == domain 1  score: 133.2 bits;  conditional E-value: 2e-42
                 XXGG--GGGTTSEEEEEEEEEEE---EEEEEEEEEEETTT-.-EE.E....S----SB-..TTT-HHH-EEE-GGGSEEEEEEEEEEE----------- CS
      MCM_OB   1 slRdlrsehigklvkveGivtrasevkpklkkavfeckkcgktve.v....eleePrkCeekeCeskdpfkletekskfvdfqklklQEspeevpaGel 94 
                 ++R+lrs+hig+l++++G+vtr+sev+p+l++  f+c +cg++   +    +++eP++C +k+C+++++++l++++s+fvd+qklk+QE++ e+p G++
  EFC35989.1 169 QIRQLRSAHIGQLISLSGVVTRSSEVRPELVEGIFHCVECGTVSDpIpqqfKYTEPTSCINKTCTNTKRWRLDMHNSRFVDWQKLKVQENTHEIPSGSM 267
                 68***************************************98887799999999******************************************** PP

                 --EEEEEEEGGGTT---TT-EEEEEEEEEEE CS
      MCM_OB  95 PrslevileddlvdkvkPGdrvevtGiyral 125
                 Pr+l++il++d+v+++k+Gdr+ +tG++ a+
  EFC35989.1 268 PRTLDIILRNDCVESAKAGDRCLFTGTLLAV 298
                 **************************98765 PP

>> MCM_lid  MCM AAA-lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.0   2.0   5.3e-30   1.2e-26       2      87 .]     685     769 ..     684     769 .. 0.95

  Alignments for each domain:
  == domain 1  score: 93.0 bits;  conditional E-value: 5.3e-30
                 HHHHHHHHHHHTT--BETCHHHHHHHHHHHHHHHHHTSSTSSSST--HHHHHHHHHHHHHHHHHHTSSSE-HHHHHHHHHHHHHHH CS
     MCM_lid   2 llrkYiayarekikPklseeakeklseaYvelRkeeedskrksipitvRqLesliRLseAlAklrlsevvteedveeairllkesl 87 
                  ++ Y++y+r+ i+P+l+++a+e+l+++Y++lR++++   ++s++itvRqLesliRLseAlA+l++++ v+ ++v++ai+llk+s+
  EFC35989.1 685 DIKLYLRYCRNCIHPILTTQAREELTKQYIKLRQNDK-VGSNSYRITVRQLESLIRLSEALARLHCESRVEINHVRRAIELLKTSI 769
                 5899******************************994.4699****************************************9985 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0     0.053   1.2e+02      15      50 ..     456     491 ..     445     513 .. 0.83
   2 !   25.8   0.0   2.6e-09   5.8e-06      94     160 ..     515     581 ..     504     612 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.053
  Mg_chelatase  15 leiaaaGgHnlllvGppGsGKtmlakrlpsllppls 50 
                    +i + G  n+ +vG p + K+   k ++ l+p+  
    EFC35989.1 456 EKIQIRGDINICIVGDPSTAKSQFLKFVSHLIPRAV 491
                   5788899************************99865 PP

  == domain 2  score: 25.8 bits;  conditional E-value: 2.6e-09
  Mg_chelatase  94 gskpkpGeislahnGvLfLDElpefkrkvlevLRePledgevtisrakakvefparfqlvaamNpcp 160
                     +++ G++ la nGv  +DE+ +++ k   ++ e +e+++++i++a  +++  ar  ++aa+Np  
    EFC35989.1 515 EFTIEAGALMLADNGVCCIDEFDKMDVKDQVAIHEAMEQQTISIAKAGIRATLNARASILAAANPIG 581
                   457889**********************************************************964 PP

>> MCM_N  MCM N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.1   5.2e-09   1.2e-05      37     104 .]      87     163 ..      82     163 .. 0.86
   2 ?   -3.0   0.5         5   1.1e+04      52      74 ..     817     839 ..     806     884 .. 0.60

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 5.2e-09
       MCM_N  37 ttLevdlddLaafdeeLaeailenpkeylplleealkevvkklepsykdd.........akefpaeltrrfqvrfkn 104
                 +++ vd++++ ++d ++a++i+++ +++ p+l + l+ v+k+  +s+  +         ++++p e++ ++q+ f n
  EFC35989.1  87 RSVMVDFTNVMNYDMDIAMSIRQEFYRFEPFLTQSLNIVYKEWIHSNITRkmidihqidQSSSPHENNSTIQLKFVN 163
                 6889************************************99777544445777776544999*********99986 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 5
       MCM_N  52 eLaeailenpkeylplleealke 74 
                 +L +++ ++ +++  +l+ al+ 
  EFC35989.1 817 DLLRNLKNQRRKIETALNLALDS 839
                 55555555555555555555543 PP

>> AAA_3  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   1.2e-07   0.00027      39     114 ..     501     581 ..     466     586 .. 0.77

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 1.2e-07
       AAA_3  39 sdilGtevfeekekefefkkGpvf...anllladeinrappktqsalleameerqvtvege..thklpepflvlatqnPie 114
                 + ++ + v ++++ ef++++G+++   + +   de ++   k q a+ eame+++++++++  + +l+    +la+ nPi 
  EFC35989.1 501 AGLTASVVKDSERGEFTIEAGALMladNGVCCIDEFDKMDVKDQVAIHEAMEQQTISIAKAgiRATLNARASILAAANPIG 581
                 4567777888899*********98433359999**********************99976522678*************95 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   6.7e-07    0.0015       1     125 [.     465     585 ..     465     604 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 6.7e-07
                 EEEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--...........--------G-SEEEEESGGG--HHHHHHHHHHHHSSEEE.. CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreik..ngttslvdsplvraaregeilvlDEveraesevlnsLlslleerrllle 97 
                 ++++vG+p t+Ks++ + +++++ r v +    +  +++ l+ ++  +   g+   + ++l+       ++++DE+++++ + + + +  +e+++++++
  EFC35989.1 465 NICIVGDPSTAKSQFLKFVSHLIPRAVYT--SGKASSAAGLTASVVKDseRGEFTIEAGALM--LADNGVCCIDEFDKMDVKDQVAIHEAMEQQTISIA 559
                 689********************776644..3445666667766664455689999999999..77889***********999***************9 PP

                 -SSSEEE---......-EEEEEESS--.... CS
       AAA_5  98 eggelvkaknddllerfrviatanpld...r 125
                 + g +   ++       +++a+anp     +
  EFC35989.1 560 KAGIRATLNAR-----ASILAAANPIGgryN 585
                 99999988886.....899999999885443 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       2.7     6e+03      69      91 ..     303     325 ..     301     328 .. 0.88
   2 !   16.6   0.0   2.2e-06    0.0049      21     142 ..     462     578 ..     450     594 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.7
                      HHHEBSSSSSTTTSS-BEHHHHH CS
  Sigma54_activat  69 eLFGhekGaFtGAekekkGlfek 91 
                      ++FG ++     A+++kkG +ek
       EFC35989.1 303 KMFGGAQSQLINANSKKKGDIEK 325
                      689999999999*******9986 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 2.2e-06
                      SSS-EEEECSTTSSHHHHHHHHHHHSTTTTS-EEEEETTTS-TTCHHHHHHEBSSSSSTTTSS-BEHHHHHTTTSEEEEETGGGS-HHHHHHHH CS
  Sigma54_activat  21 tdlsvlitGesGtGKellaraiheaskrkekpfvavncaaipeelleseLFGhekGaFtGAekekkGlfekadgGtlfLDeigelplelQekLl 114
                       d+++ i+G+  t K+ + + + +  +r+     +   a+ ++ l +s +   e+G Ft     ++G++  ad+G+  +De  +++++ Q+ + 
       EFC35989.1 462 GDINICIVGDPSTAKSQFLKFVSHLIPRAV---YTSGKASSAAGLTASVVKDSERGEFT----IEAGALMLADNGVCCIDEFDKMDVKDQVAIH 548
                      557777777777777777777777666543...34455555666777766677778777....468**************************** PP

                      HHHHHSEE..ESBTSSSEEE--EEEEEEES CS
  Sigma54_activat 115 rvlqegev..ervGsskeikvdvriiaatn 142
                      ++++++++   + G +++ ++   i+aa+n
       EFC35989.1 549 EAMEQQTIsiAKAGIRATLNARASILAAAN 578
                      ****99752268999999999999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (953 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2800  (0.156172); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.04u 0.39s 00:00:01.43 Elapsed: 00:00:00.57
# Mc/sec: 5072.87
//
Query:       EFC35990.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.7e-25   88.4   0.0    8.8e-25   86.7   0.0    1.9  2  ADH_N_2        N-terminal domain of oxidoreductase
    4.5e-21   75.2   0.1    7.8e-21   74.4   0.1    1.4  1  ADH_zinc_N     Zinc-binding dehydrogenase
    2.5e-10   41.5   0.0    6.6e-10   40.2   0.0    1.7  2  ADH_zinc_N_2   Zinc-binding dehydrogenase
     0.0044   16.8   0.0        2.1    8.0   0.0    2.2  2  DUF2855        Protein of unknown function (DUF2855)
  ------ inclusion threshold ------
      0.075   12.7   0.1       0.13   11.9   0.1    1.4  1  ELFV_dehydrog  Glutamate/Leucine/Phenylalanine/Valine dehydro


Domain annotation for each model (and alignments):
>> ADH_N_2  N-terminal domain of oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.7   0.0   2.5e-28   8.8e-25       4      99 ..      11     110 ..       8     119 .. 0.88
   2 ?   -2.7   0.0       1.5   5.5e+03      27      35 ..     156     164 ..     153     179 .. 0.74

  Alignments for each domain:
  == domain 1  score: 86.7 bits;  conditional E-value: 2.5e-28
     ADH_N_2   4 vlkkrpegaptesdfeleee.elp.elkdGevlvralylSvDPymRgrmnda..ksyvepvelgdvmrggavgeVveSknpdfkvGdlVvgllgwqdya 98 
                 +  + peg ++esdf+++ + e+  +l+++e+lv+ l+lSvDPymRgrm+++  k y + +e+g+++ gg+v++V++S++++fk+Gd+ +g+ +wq+  
  EFC35990.1  11 IYSSYPEGLVKESDFTYNAAlEIDsTLQADEILVELLHLSVDPYMRGRMSKNvpKGYFPAFEIGKPINGGGVAKVLKSNHENFKEGDVLLGYFDWQKIQ 109
                 66789**********99875244349***********************9965699****************************************965 PP

     ADH_N_2  99 v 99 
                  
  EFC35990.1 110 K 110
                 4 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.5
     ADH_N_2  27 elkdGevlv 35 
                 ++k+Gev+v
  EFC35990.1 156 QPKEGEVVV 164
                 677888776 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.4   0.1   2.2e-24   7.8e-21       1     123 [.     171     304 ..     171     314 .. 0.83

  Alignments for each domain:
  == domain 1  score: 74.4 bits;  conditional E-value: 2.2e-24
                 HHHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTTESEEEET....TTC.HHHHHHHHHTT.TSSEEEEEESSCSHHHHHHHHHCEEEEEEEEECSC..T CS
  ADH_zinc_N   1 gvGlaavqlAkalGaeviavdsseeklelakklGadeviny....kea.dlverikeltg.gegvdvvfecvGsgatleaalkllkpgGrlvvvGg..g 91 
                 +vG+++ qlAk+ G++vi++++s e+++ +k+lG de+iny    +++  l+e+i+++   + gvd +f+ vG g +l+a + ++++ Gr+ ++G    
  EFC35990.1 171 AVGSLVGQLAKIKGCKVIGISGSTENVQHLKDLGFDEIINYkdfnNDTnALKEAIEKAALpKTGVDCYFDNVG-GFVLDAVTLSMNRYGRISCCGSisE 268
                 69***************************************6665444458888888886688**********.**********************975 PP

                 SSEEE...EEHHHHH.HTT-EEEEE-SSCHHHHHHH CS
  ADH_zinc_N  92 kgeee...fdlrnll.lkeksilGsllgslreefke 123
                 +++++    +l+ +   +e++i+G+++gs  +++ e
  EFC35990.1 269 YNGQKdlgPRLNSVYvVRELKIQGFIVGSFYHRLDE 304
                 55554666334445449***********97776655 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       4.2   1.5e+04      39      54 ..     151     167 ..     139     185 .. 0.65
   2 !   40.2   0.0   1.8e-13   6.6e-10       1     133 []     203     349 ..     203     349 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.2
                   HHHHE.EEEEEEEE--- CS
  ADH_zinc_N_2  39 slkvl.pggGrlvsigg 54 
                    l+++ p++G +v++++
    EFC35990.1 151 FLDICqPKEGEVVVVSA 167
                   45666677788887774 PP

  == domain 2  score: 40.2 bits;  conditional E-value: 1.8e-13
                   TT-SEEEETTSTTHH..........HHH-TT-EEEEEES-HHHHH.HHHHHHEEEEEEEEE----.........S-EEE-CHHHCTTT-EEEE--GG CS
  ADH_zinc_N_2   1 lGAdevidyrtedfe..........aatggegvDvvldtvggealleaslkvlpggGrlvsiggpp........lsaallkpakkrkgrsvkyeflf 79 
                   lG+de+i+y++ +            aa+ + gvD  +d+vgg  l +a+   ++ +Gr+ + g+ +        l    +++++    r +k++   
    EFC35990.1 203 LGFDEIINYKDFNNDtnalkeaiekAALPKTGVDCYFDNVGGFVL-DAVTLSMNRYGRISCCGS-IseyngqkdL---GPRLNSVYVVRELKIQG-- 292
                   8******999333335799999998777789**********9999.8887667899***77775.2234443221...22222222233333333.. PP

                   G...-........-HHHHHHHHHHHHHHH----EEEEEEGGGHHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  80 smkas.......aqadileelaalieeGklrpvvdrvfpleeaaeAhrylesgrarGKiVl 133
                       +       +  +  +++++++ eGkl++  ++v +le++++A+ +l +g  +GK+++
    EFC35990.1 293 ----FivgsfyhRLDEGVKAMTKWVLEGKLKVLESKVAGLENIPKALIKLFTGDKVGKMII 349
                   ....24444477555558*****************************************97 PP

>> DUF2855  Protein of unknown function (DUF2855)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0   0.00057       2.1      43      71 ..      81     109 ..      77     128 .. 0.86
   2 !    6.6   0.0    0.0016       5.6     145     210 ..     161     220 ..     144     247 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00057
     DUF2855  43 GfatVveStvpkiavGerlyGylPiashl 71 
                 G a+V++S++++ ++G  l Gy+   +  
  EFC35990.1  81 GVAKVLKSNHENFKEGDVLLGYFDWQKIQ 109
                 89********************9776655 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0016
     DUF2855 145 kvvvllsASsKTAlslayllrkrrkaeegplklvglT.SaknrafveslglydkvvsYddlesleaa 210
                 +vvv+++AS+  +  +  +l+k +       k++g++ S +n++  ++lg+ d++++Y+d+++ ++a
  EFC35990.1 161 EVVVVSAASGAVGSLVG-QLAKIKG-----CKVIGISgSTENVQHLKDLGF-DEIINYKDFNNDTNA 220
                 48899999998887777.5555554.....79***9748889999999997.99*******987776 PP

>> ELFV_dehydrog  Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   3.8e-05      0.13      31      94 ..     159     223 ..     143     242 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3.8e-05
                    TTEEEEEE--.SHHHHHHHHHHHHCT-EEEEEEESSEEEEETTEE-HHHHHHHHHCSSSSTTHSH CS
  ELFV_dehydrog  31 egkrvaisGs.GnvgsyaallltelgakvvavsDssGviydpeGldieellelkeerksvkeykk 94 
                    eg+ v++s   G vgs + +l++ +g kv+++s s+  + + + l ++e++++k+ ++  + +k+
     EFC35990.1 159 EGEVVVVSAAsGAVGSLVGQLAKIKGCKVIGISGSTENVQHLKDLGFDEIINYKDFNNDTNALKE 223
                    78889999888*****************************************9987777666664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       408  (0.0227564); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2038.72
//
Query:       EFC35991.1  [L=456]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.6e-86  288.0   0.1    1.1e-85  287.8   0.1    1.0  1  AMP-binding    AMP-binding enzyme
    1.2e-16   61.5   0.2    3.4e-16   60.0   0.2    1.8  1  AMP-binding_C  AMP-binding enzyme C-terminal domain
  ------ inclusion threshold ------
       0.11   11.5   0.2       0.16   11.0   0.2    1.2  1  DNA_pol_A      DNA polymerase family A


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  287.8   0.1   1.9e-89   1.1e-85      50     422 ..       2     363 ..       1     364 [. 0.91

  Alignments for each domain:
  == domain 1  score: 287.8 bits;  conditional E-value: 1.9e-89
                  EEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHHTESEEEETCTCCCHHHHHHHHSCC-EECEEEEESCCS-HCCHCCCHCCCCSCTT CS
  AMP-binding  50 VaillpnspewvvallailkaGavvvplnptltaeelayiledseakvliatvdselleklleaaakleavklvivldadellkeeelkeeeeseeka 147
                  +a++lpn p + v++++i ++G++v +lnp ++ ee++ +l+ds+a ++i  ++++ lek+++  ++  +vk+  vld ++   e+ lk ee   +++
   EFC35991.1   2 IAVMLPNLPLFPVLFHGISYVGGIVTTLNPLYSYEEIQSQLADSGAIMMI--TSKDFLEKAQKSIEN-TKVKQLFVLDLKDEIVENVLKVEETLLKES 96 
                  89************************************************..888888888777775.688888999999988888887777666655 PP

                  .S....-TSCCCS-BTTSEEEEEEE--SSSS-EEEEEEHHHHHHHHHHHHHHHCSCCTTT-EEEESS-TTSCHHHHHHHHHHHHTT-EEEE-TTCGCC CS
  AMP-binding 148 .e....kpeeeeelkpddlayiiYTSGTTGkPKGVmlshrnlvanvaslkletrfklkeddvvlsilplahifglilelllallsGatvvllpkdaal 240
                   +    +  +++ ++++d+  + Y+SGT G  KGV l+h n+++n+ ++ ++  +k++++d  +++lp++hi+gl+l +++al+ Ga+vv + +++  
   EFC35991.1  97 vRtemiN--TVSFNTKEDVFAVPYSSGTVGLCKGVCLTHFNTLSNILQFRCSV-EKISSGDCTIAVLPFFHIYGLTLICNAALYEGAKVVTMARFDL- 190
                  5156532..5567999********************************87554.456789*********************************9988. PP

                  HHHHHHHHHHHHT-SEEEEEHHHHHHHHHCCCHHCHHHHCCGTT-SEEEEESS-EBHHHHHHHHHHHTCEEEEEEEEGGGSSECEECHCTTTCTSTTS CS
  AMP-binding 241 dpklllelieklkvtviagvPrvleallesgalkaakkakdlsslrlvllggeplspellrffralfgeevlegYGlTEttgvvtvlpleedkkklgs 338
                    +++l+ i++++vt i++vP ++ al++++ ++    +++l s+++++++++pls+e++  +++++   v +gYGlTEt++v++v+  ++d++k+gs
   EFC35991.1 191 --ETFLRNIQTHQVTRIHLVPPIMIALAKHPLIE----KYNLTSIKTLVSAAAPLSAEVASMVSKRLNVIVKQGYGLTETGPVCCVC--PDDNVKVGS 280
                  ..4578***********************99888....569**************************99***************944..466689*** PP

                  -BEE-TTEEEEEE-TTTSCBE.ETTSEEEEEEEETTS-SEBTT-HHHHHHHEEETCCEEEEEEEEEEETTSEEEEEEECCCEEEE CS
  AMP-binding 339 vGkplpgvevkivDeetgepv.pdgeeGellvrgpgvmkgYlkkpeataeafdsegrwlrTGDlgrldedGyleivgRkkdlikl 422
                  vG  lp +++ki+D et+e++ + g++Gel+++gp++mkgYl+++eat+ ++  + ++ +TGD+g++d dG l+iv+R k+lik 
   EFC35991.1 281 VGLLLPLTDLKILDLETEEEItQVGKQGELCFSGPQMMKGYLNNEEATKYTLR-N-GFIHTGDVGYIDSDGFLYIVDRVKELIKY 363
                  ****************99999459999*************************8.5.7**************************96 PP

>> AMP-binding_C  AMP-binding enzyme C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.0   0.2   5.7e-20   3.4e-16       1      76 []     372     447 ..     372     447 .. 0.95

  Alignments for each domain:
  == domain 1  score: 60.0 bits;  conditional E-value: 5.7e-20
                    HHHHHHHSSTTEEEEEEE-----TTS---EEEEEE------HHHHHHHHHHHHT-TTTS-SEEEE-S---B-TTS- CS
  AMP-binding_C   1 evEsalvshpaVaeaaVvGvpdevkGealvafVvlkdgsealeeeLkahvrkelgpyavpkkvvfvdelpktrsGK 76 
                    e+E +l++hp++ +aaV+G++de+ Ge ++afVv ++++++ e+e++ +v++++ p  + + v+fv+e+pk  sGK
     EFC35991.1 372 ELEGILLKHPKILDAAVIGIQDETVGELPKAFVVMRPNETLSEDEVMNFVAEHVSPQRRVRLVEFVKEIPKSSSGK 447
                    89********************************987755579********************************9 PP

>> DNA_pol_A  DNA polymerase family A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.2   2.7e-05      0.16     298     362 ..      38     109 ..      36     122 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 2.7e-05
                 HHHHHHHHHHHHHHHHHHHHHHTT-SEE.......EEEEETTEEEEEEECCCHHHHHHHHHHHHHHHHHSSS CS
   DNA_pol_A 298 iQGsAaDiiklamikieealkeeklkar.......lllqvHDElvfevpeeeveevaelvkeamesaveldv 362
                 iQ+  aD   ++mi  ++ l++++ + +       ++l + DE+v +v + e   ++e v+++m ++v+++ 
  EFC35991.1  38 IQSQLADSGAIMMITSKDFLEKAQKSIEntkvkqlFVLDLKDEIVENVLKVEETLLKESVRTEMINTVSFNT 109
                 8999999999****999999776654223344455*****************************99998633 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (456 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       596  (0.0332422); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 2588.70
//
Query:       EFC35992.1  [L=453]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-06   26.3   0.2    3.2e-05   23.6   0.0    2.5  2  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
     0.0001   22.9   0.1     0.0011   19.5   0.0    2.8  4  RCC1      Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.018   15.3   1.5       0.91    9.9   0.0    3.6  4  Kelch_6   Kelch motif
       0.19   11.3   0.6         18    5.0   0.0    3.1  3  Kelch_1   Kelch motif


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   0.0   7.1e-09   3.2e-05       1      30 []     301     330 ..     301     330 .. 0.93
   2 ?   -2.7   0.0       1.2   5.5e+03       2      17 ..     358     373 ..     357     376 .. 0.75

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 7.1e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++ +G +H ++Lt dG+V++ G N + Q
  EFC35992.1 301 IIQLESGFDHCVVLTQDGKVYAMGINQYSQ 330
                 78999*******************999876 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.2
      RCC1_2   2 ksvsaGdyHscaLted 17 
                   + +G+  +  Lte+
  EFC35992.1 358 LRIGCGSTYTALLTES 373
                 5678999888889887 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.5   6.5e+03      35      46 ..     119     130 ..     101     134 .. 0.70
   2 ?   -1.6   0.0      0.95   4.3e+03      35      50 .]     298     314 ..     292     314 .. 0.78
   3 !   19.5   0.0   2.5e-07    0.0011       1      50 []     317     370 ..     317     370 .. 0.72
   4 ?   -2.5   0.0       1.9   8.6e+03      36      50 .]     410     424 ..     400     424 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.5
                 S-EEEEEEETTE CS
        RCC1  35 nrvvkvacGddh 46 
                  ++v+v++ ++ 
  EFC35992.1 119 SPIVQVVSSGNC 130
                 299998887765 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.95
                 S.-EEEEEEETTEEEEE CS
        RCC1  35 n.rvvkvacGddhtval 50 
                 +  +++  +G dh+v+l
  EFC35992.1 298 KsQIIQLESGFDHCVVL 314
                 34899999******986 PP

  == domain 3  score: 19.5 bits;  conditional E-value: 2.5e-07
                 TTEEEEEE--GGGTTSSSS---E....EE....EEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesv....lv....Ptkveglsgn..rvvkvacGddhtval 50 
                 dG+Vy+ G n+y q+G  +++s+     v    Pt          rv  + cG+ +t++l
  EFC35992.1 317 DGKVYAMGINQYSQCGMLPDQSNivrqFVeiipPTM------YhsRVLRIGCGSTYTALL 370
                 9****************7776662222334453333......1349*********99975 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 1.9
                 -EEEEEEETTEEEEE CS
        RCC1  36 rvvkvacGddhtval 50 
                  + ++ c + h +a+
  EFC35992.1 410 GINDIYCAGWHLCAI 424
                 577899999999887 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0    0.0002      0.91      12      41 ..      25      56 ..      23      58 .. 0.90
   2 ?    0.8   0.0      0.15   6.7e+02       6      17 ..     267     278 ..     264     294 .. 0.82
   3 ?    0.2   0.0      0.23     1e+03       9      21 ..     315     327 ..     308     342 .. 0.75
   4 ?   -3.2   0.0       2.7   1.2e+04      11      23 ..     372     384 ..     366     388 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0002
     Kelch_6 12 gkiYifGGytds..spylnkvwvydpetksWe 41
                + + ++G y ++  ++++++++++d+ tks +
  EFC35992.1 25 NNLLVMGSYFGYfaTSHFKDWHRIDLHTKSSQ 56
                66899****9999****************977 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.15
     Kelch_6   6 slvsvggkiYif 17 
                 ++v+ ++kiYi+
  EFC35992.1 267 AVVTNDNKIYIL 278
                 678999*****8 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.23
     Kelch_6   9 svggkiYifGGyt 21 
                 + +gk+Y++G + 
  EFC35992.1 315 TQDGKVYAMGINQ 327
                 4688*****9765 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 2.7
     Kelch_6  11 ggkiYifGGytds 23 
                  ++i i+G  t+s
  EFC35992.1 372 ESHILIVGRFTGS 384
                 5799999988874 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.1     0.018        81       5      17 ..     266     278 ..     264     279 .. 0.88
   2 ?    5.0   0.0    0.0039        18       4      18 ..     310     324 ..     308     324 .. 0.93
   3 ?   -1.8   0.0      0.53   2.4e+03      12      19 ..     412     419 ..     412     420 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.018
                 EEEEEETTEEEEE CS
     Kelch_1   5 agavvvggkiYvi 17 
                 +++v+ ++kiY++
  EFC35992.1 266 YAVVTNDNKIYIL 278
                 589********85 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0039
                 SEEEEEETTEEEEEE CS
     Kelch_1   4 gagavvvggkiYviG 18 
                 ++++ + +gk+Y++G
  EFC35992.1 310 HCVVLTQDGKVYAMG 324
                 7999**********9 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.53
                 TEEEEEEE CS
     Kelch_1  12 gkiYviGG 19 
                 + iY+ G+
  EFC35992.1 412 NDIYCAGW 419
                 78*****7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (453 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 2552.68
//
Query:       EFC35993.1  [L=344]
Description: peroxidase PPOD1, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-31  110.1   0.0    3.3e-09   36.7   0.0    5.3  5  FRG1          FRG1-like domain
    2.5e-24   85.6   0.0    5.2e-08   33.1   0.0    4.1  4  Fascin        Fascin domain
    2.1e-09   37.7   0.1    3.3e-09   37.0   0.1    1.4  1  EF-hand_7     EF-hand domain pair
    6.5e-07   28.8   0.3     0.0052   16.6   0.0    2.5  2  EF-hand_6     EF-hand domain
    5.2e-06   26.2   0.0        1.2    8.8   0.0    3.7  5  DUF569        Domain of unknown function (DUF569)
    0.00011   21.5   0.1     0.0093   15.5   0.0    2.4  2  EF-hand_1     EF hand
     0.0031   16.9   0.0      0.007   15.8   0.0    1.6  1  EF-hand_5     EF hand
  ------ inclusion threshold ------
      0.024   14.5   0.1      0.098   12.5   0.0    1.9  2  EF-hand_8     EF-hand domain pair
       0.16   12.3   0.3       0.25   11.7   0.3    1.3  1  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca


Domain annotation for each model (and alignments):
>> FRG1  FRG1-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0    0.0007       1.4      42      77 ..     106     141 ..      82     145 .. 0.85
   2 !   22.0   0.0   5.5e-08   0.00011      32      81 ..     138     186 ..     135     187 .. 0.88
   3 !   21.9   0.0   5.7e-08   0.00011      37      73 ..     182     218 ..     179     221 .. 0.92
   4 !   18.6   0.0   5.9e-07    0.0012      35      74 ..     221     260 ..     218     266 .. 0.92
   5 !   36.7   0.0   1.7e-12   3.3e-09      39     111 ..     266     338 ..     260     343 .. 0.92

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0007
        FRG1  42 slKsgyGkYlgvdkegilsaraeAisseEqfevvfe 77 
                  l+s + kY+ ++ +g+++a+ +A ++ E  +++  
  EFC35993.1 106 NLRSCHSKYFCIEPSGQVVANRDASGAWEAMTLIHI 141
                 5899*************************9999865 PP

  == domain 2  score: 22.0 bits;  conditional E-value: 5.5e-08
        FRG1  32 avkvasdekislKsgyGkYlgvdkegilsaraeAisseEqfevvfeegkt 81 
                 ++++ s +  ++Ks +Gk++  + +g ++a+ +A+++ E f +v + +++
  EFC35993.1 138 LIHI-SGNDYAFKSAHGKFMCAEPSGEIIANRDALGPWETFSLVQSGNQV 186
                 5667.77889*********************************9887665 PP

  == domain 3  score: 21.9 bits;  conditional E-value: 5.7e-08
        FRG1  37 sdekislKsgyGkYlgvdkegilsaraeAisseEqfe 73 
                 s +++++Ks +Gk+l  + +g+++a+ +A+++ Eqf+
  EFC35993.1 182 SGNQVAFKSAHGKFLCAEPSGLVIANRDALGPWEQFQ 218
                 6789*******************************97 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 5.9e-07
        FRG1  35 vasdekislKsgyGkYlgvdkegilsaraeAisseEqfev 74 
                 +a ++ isl+ ++Gk l  +++  ++a+ +A+++ Eqf+v
  EFC35993.1 221 LAPNQSISLRHHHGKLLCAESNHSMVANRDAVGPWEQFTV 260
                 567899********************************97 PP

  == domain 5  score: 36.7 bits;  conditional E-value: 1.7e-12
        FRG1  39 ekislKsgyGkYlgvdkegilsaraeAisseEqfev.vfeegktallalaketflsvdeekdivakskkaaeee 111
                  k +++s +Gk +  + +g+l+a+ +A+++ Eqf v +  +g  al + +++t++ v++++div++++ ++e e
  EFC35993.1 266 GKNAFRSAHGKLMCAEPSGLLVANRDAVGPWEQFSVeLHGNGAIALKS-EHNTYVCVEPSGDIVVNRSAVGEWE 338
                 5789******************************9978999999**99.******************9999866 PP

>> Fascin  Fascin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   9.1e-06     0.018      23     107 ..      47     134 ..      25     138 .. 0.83
   2 !   33.1   0.0   2.6e-11   5.2e-08      32     110 ..     142     218 ..     134     219 .. 0.92
   3 !   29.5   0.0   3.5e-10   6.9e-07      29     111 .]     219     301 ..     215     301 .. 0.90
   4 !    7.0   0.0    0.0033       6.6      68     105 ..     298     336 ..     297     341 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 9.1e-06
                 GGGEEEEEEETTSEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEE...TCEEEEEETTSCEEEECTTTEEEEEESSSSGGG CS
      Fascin  23 kkqlftLefdeesyavaLrshngkYlsldkdGrvvaeaetkeedtlFelefr...grwallresngryLgigkeglLkasastvgkde 107
                  k lf+L+   +s+++ L ++ + Yl ++  G  + + +   ++  ++++     +  a lr+++ +y++i+++g+++a+ ++ g+ e
  EFC35993.1  47 IKFLFKLVDHAKSKSISLSDFINVYLFVTGGGMSYPGTNYSGPHGSYTVHSAkhrSLLANLRSCHSKYFCIEPSGQVVANRDASGAWE 134
                 4568999988889999***********777777777788899999999998864455566899*****************99988765 PP

  == domain 2  score: 33.1 bits;  conditional E-value: 2.6e-11
                 ETTSEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEETCEEEEEETTSCEEEECTTTEEEEEESSSSGGGEEE CS
      Fascin  32 deesyavaLrshngkYlsldkdGrvvaeaetkeedtlFelefrgrwallresngryLgigkeglLkasastvgkdelft 110
                 + + ya  ++s+ gk++ ++ +G++ a+++   +   F+l  +g  +++++ +g++L+++++gl+ a+ +++g+ e f+
  EFC35993.1 142 SGNDYA--FKSAHGKFMCAEPSGEIIANRDALGPWETFSLVQSGNQVAFKSAHGKFLCAEPSGLVIANRDALGPWEQFQ 218
                 455788..******************************************************************99997 PP

  == domain 3  score: 29.5 bits;  conditional E-value: 3.5e-10
                 EEEETTSEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEE.TCEEEEEETTSCEEEECTTTEEEEEESSSSGGGEEEE CS
      Fascin  29 LefdeesyavaLrshngkYlsldkdGrvvaeaetkeedtlFelefr.grwallresngryLgigkeglLkasastvgkdelftl 111
                 ++  ++++ + Lr h gk l ++++ + va+++   +  +F++e + +++ ++r+ +g+ ++++++glL+a+ ++vg+ e f++
  EFC35993.1 219 FSLAPNQS-ISLRHHHGKLLCAESNHSMVANRDAVGPWEQFTVEHHgAGKNAFRSAHGKLMCAEPSGLLVANRDAVGPWEQFSV 301
                 44444444.48***********************************989999999*************************9985 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0033
                 EEEEEEE.TCEEEEEETTSCEEEECTTTEEEEEESSSSG CS
      Fascin  68 lFelefr.grwallresngryLgigkeglLkasastvgk 105
                 +F++e + ++ ++l++ +  y++++++g+++ + s+vg+
  EFC35993.1 298 QFSVELHgNGAIALKSEHNTYVCVEPSGDIVVNRSAVGE 336
                 6999999889999999999*******9999999999987 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   0.1   1.7e-12   3.3e-09       3      70 ..      12      71 ..      10      72 .. 0.89

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 1.7e-12
   EF-hand_7  3 klkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkly 70
                + +  F+++D+d++++l+k e +++ +      + g  l +ee++ lfk +D+ k+ +is+++F + y
  EFC35993.1 12 QAQSTFQQYDKDHSNSLNKKEWKKAAQ------DIG--LAKEEIKFLFKLVDHAKSKSISLSDFINVY 71
                56778******************9999......555..55789*********************9887 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   2.6e-06    0.0052       3      27 ..      14      38 ..      12      41 .. 0.88
   2 !    9.8   0.1   0.00041      0.81       1      26 [.      46      71 ..      46      74 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 2.6e-06
   EF-hand_6  3 reaFklfDkdgdGkidaeElrkalr 27
                ++ F+++Dkd++++++++E++ka +
  EFC35993.1 14 QSTFQQYDKDHSNSLNKKEWKKAAQ 38
                789******************9976 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00041
   EF-hand_6  1 elreaFklfDkdgdGkidaeElrkal 26
                e++ +Fkl D+ ++ +i+ +++++++
  EFC35993.1 46 EIKFLFKLVDHAKSKSISLSDFINVY 71
                68899*****************9975 PP

>> DUF569  Domain of unknown function (DUF569)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.045        89      41      65 ..      92     116 ..      83     128 .. 0.81
   2 !    7.1   0.0     0.002         4      11      67 ..     106     159 ..      97     166 .. 0.72
   3 !    8.4   0.0   0.00083       1.7       7      72 ..     143     204 ..     136     208 .. 0.78
   4 !    8.8   0.0   0.00062       1.2       8      73 ..     225     287 ..     219     293 .. 0.82
   5 ?   -1.9   0.0       1.2   2.4e+03       9      24 ..     308     323 ..     301     336 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.045
      DUF569  41 kwtvevvekkaelirlkscyGkylt 65 
                  +tv   ++++ l  l+sc+ ky+ 
  EFC35993.1  92 SYTVHSAKHRSLLANLRSCHSKYFC 116
                 6788888888888999999999975 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.002
      DUF569  11 rlrsvhdkylvadedeetvrqdrdGsakrakwtvevvekkaelirlkscyGkyltas 67 
                  lrs+h ky+  +   + v+ +rd s         +++ + +   +ks++Gk++ a 
  EFC35993.1 106 NLRSCHSKYFCIEPSGQVVA-NRDASGAWEAM--TLIHISGNDYAFKSAHGKFMCAE 159
                 79*******99987776665.55554433333..445555577889*******9985 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.00083
      DUF569   7 akavrlrsvhdkylvadedeetvrqdrdGsakrakwtvevvekkaelirlkscyGkyltasnkpll 72 
                 ++   ++s h k++ a+   e +++ r   +    w    ++++ + + +ks++Gk+l a  + l+
  EFC35993.1 143 GNDYAFKSAHGKFMCAEPSGEIIAN-R---DALGPWETFSLVQSGNQVAFKSAHGKFLCAEPSGLV 204
                 5566788999999999998887764.3...44567888888888999***********99876665 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.00062
      DUF569   8 kavrlrsvhdkylvadedeetvrqdrdGsakrakwtvevvekkaelirlkscyGkyltasnkplll 73 
                 +++ lr +h k l a+ ++ ++  +rd      ++tve      +   ++s++Gk + a  + ll+
  EFC35993.1 225 QSISLRHHHGKLLCAESNH-SMVANRDAVGPWEQFTVEHHGAGKNA--FRSAHGKLMCAEPSGLLV 287
                 6789*******99997765.5667899999999*****98877775..579****99998887775 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 1.2
      DUF569   9 avrlrsvhdkylvade 24 
                 a+ l+s h++y+  + 
  EFC35993.1 308 AIALKSEHNTYVCVEP 323
                 6778888888877664 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   4.7e-06    0.0093       3      26 ..      14      37 ..      12      40 .. 0.88
   2 ?    3.8   0.0     0.025        50       1      24 [.      46      69 ..      46      71 .. 0.91

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 4.7e-06
                HHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1  3 keiFrefDkDgdGkIdfeEfkell 26
                +  F+ +DkD++  ++++E+k++ 
  EFC35993.1 14 QSTFQQYDKDHSNSLNKKEWKKAA 37
                568******************986 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.025
                HHHHHHHHHTTTSSSEEEHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfke 24
                e+k +F+++D  ++  I++++f++
  EFC35993.1 46 EIKFLFKLVDHAKSKSISLSDFIN 69
                7999*****************987 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   3.5e-06     0.007       3      23 ..      15      35 ..      13      37 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 3.5e-06
                HHHHHH-SS-SSCE-HHHHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeELkt 23
                 tFq+ D++++  ++k E+k+
  EFC35993.1 15 STFQQYDKDHSNSLNKKEWKK 35
                69*****************96 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.47   9.3e+02      28      48 ..      13      33 ..      11      39 .. 0.80
   2 ?   12.5   0.0   4.9e-05     0.098      21      51 ..      39      70 ..      27      72 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.47
   EF-hand_8 28 vdilfrefDtdgdGkisfeEF 48
                +++ f   D d+++ ++++E 
  EFC35993.1 13 AQSTFQQYDKDHSNSLNKKEW 33
                67778999*********9995 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 4.9e-05
   EF-hand_8 21 k.glseeevdilfrefDtdgdGkisfeEFcvl 51
                + gl +ee+  lf+++D  ++  is+ +F+++
  EFC35993.1 39 DiGLAKEEIKFLFKLVDHAKSKSISLSDFINV 70
                35699************************986 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.3   0.00013      0.25      50     111 ..       7      68 ..       2      70 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00013
  SPARC_Ca_bdg  50 keckepvawkFsklDtnsdkvlsksELaplraplvklehCikpflescDadkdkkislkEwc 111
                   ++  ++++  F++ D+++ ++l+k+E ++  +++    + ik +++  D  k k+isl++++
    EFC35993.1   7 QQLISQAQSTFQQYDKDHSNSLNKKEWKKAAQDIGLAKEEIKFLFKLVDHAKSKSISLSDFI 68 
                   5566778889************************999999*****************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       503  (0.0280551); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 2301.78
//
Query:       EFC35994.1  [L=311]
Description: 3-isopropylmalate dehydratase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-16   59.5   0.0    5.6e-16   59.2   0.0    1.1  1  PAC2      PAC2 family


Domain annotation for each model (and alignments):
>> PAC2  PAC2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.2   0.0   3.1e-20   5.6e-16       1     211 [.      48     294 ..      48     296 .. 0.88

  Alignments for each domain:
  == domain 1  score: 59.2 bits;  conditional E-value: 3.1e-20
                 EEEESSCGGGHHHHHHHHHHHHTTEEEEEEEEHCCHSBCCCC.SEEEEETTEEE-SEEEEEETTT.SEEEEEEE....E-HSCHHHHHHHHHHHHHHHT CS
        PAC2   1 LilGfpgiGnVgqlavdlLiesleaekvgeidsdyllpfvgprpvvlveegrelepprlyakdsgsrdllvlqg....repilqyeefakalldwaeel 95 
                 Li+Gfp+     + a+ +++e+l++  +g + s+  +p     pv l+++ ++ + +r+y ++    +++v+++     +p +  + +++al ++ +++
  EFC35994.1  48 LIEGFPSGATTISTAAGYVVEQLDLPLIGDVISEV-FP-----PVCLINNYTPQSGVRIYGNN----KIVVFTSeyelKDPFVSHQ-MVNALFEFGKRH 135
                 8*********************************9.**.....**999999*********666....8*********888888888.************ PP

                 TESEEEEEEEEEESS-..................................ES..TTS-.EEEEEESSHHHHHHH.HCT......-CEEEEHHHHHHHHH CS
        PAC2  96 gvkevvvLggldager..................................advphtrpekvtgaatdeelleel.ees......eyggivgitglLlsa 153
                 g+k +v L++++  e+                                  +d++ ++ ++++ + +d+e+++ l +        ++ + +gi+++ l+ 
  EFC35994.1 136 GCKCIVSLEAIPMDEKkkrliagedvediqtpihppsreellklltaasnEDTS-DQSDSIYFITNDQEMADTLvK-YghfpikDNMVLSGISSVVLGK 232
                 ************7777******************99999999999988874443.455589999999999999944.334566699999********** PP

                 HHHTT-EEEEEEEEEECCC..--HHHHHHHHHHHHHHHT--..-HCHHHHHHHHHHHHHHHH CS
        PAC2 154 akergipavgllaevphyl..pdPkaaaalleflskllgle..vdtedLeedaeeleeqlee 211
                 a   ++ +vgl+a+++      + k  ++++++++kllg e  ++t++Le+  e+++ +l+e
  EFC35994.1 233 APFTDLVVVGLFAPISLTQeiLSTKPIISIVHAIDKLLGEElfIKTDKLEKTGEAIRIKLNE 294
                 ***************99643445555678*********9665599**********9999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       589  (0.0328518); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1877.41
//
Query:       EFC35995.1  [L=569]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.9e-25   87.1   1.9    9.3e-11   42.2   1.0    4.7  4  Ank_2     Ankyrin repeats (3 copies)
    3.5e-19   66.9   2.3     0.0083   16.6   0.1    7.3  8  Ank_3     Ankyrin repeat
    8.3e-18   64.2   2.1      0.073   13.4   0.0    6.3  6  Ank_5     Ankyrin repeats (many copies)
    2.4e-16   59.9   0.6      0.011   16.3   0.0    5.2  5  Ank_4     Ankyrin repeats (many copies)
    3.3e-13   49.4   0.9    0.00045   20.5   0.2    5.0  5  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0    0.0026       9.4      12      47 ..      53      87 ..      10      99 .. 0.60
   2 !   27.5   0.3     1e-09   3.6e-06      25      80 ..     172     236 ..     146     239 .. 0.79
   3 !   42.2   1.0   2.6e-14   9.3e-11       3      82 ..     179     277 ..     177     278 .. 0.79
   4 !   31.7   0.0   4.9e-11   1.8e-07       8      83 .]     391     490 ..     379     490 .. 0.72

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0026
       Ank_2 12 lvklLlegadpnkngktaLhyAakng.nleivklLle 47
                lvk  l+g++  + g+ ++h+A+  + ++e+ + L+ 
  EFC35995.1 53 LVKKSLFGTN--SRGLQPIHTACFFNeSEELFRELVR 87
                2222222222..2466666666664423355555553 PP

  == domain 2  score: 27.5 bits;  conditional E-value: 1e-09
       Ank_2  25 ngktaLhyAakngnleivklLleh........adndgrtpLhyAarsghleivklLlek.gadin 80 
                 +g + + yA+k++ l++vk +le+        +dn+ ++pL  A+  g +++vk+L++  ++d++
  EFC35995.1 172 QGVSLINYACKYNRLHLVKKMLEKsnidvnlhVDNYYHNPLTSAVLGGAFNVVKYLIDEvKVDVE 236
                 7889999***************9666776666779999*******99**********65466665 PP

  == domain 3  score: 42.2 bits;  conditional E-value: 2.6e-14
       Ank_2   3 lAakngnlelvklLl..egadpn...k.ngktaLhyAakngnleivklLleh.........ad....ndgr.tpLhyAarsghleivklLlekgadinl 81 
                 +A+k++ l+lvk +l  ++ d+n   +   +++L  A+ +g  ++vk+L+++          +    +d   ++Lh+A+  gh+ei+ +L+ +ga++n+
  EFC35995.1 179 YACKYNRLHLVKKMLekSNIDVNlhvDnYYHNPLTSAVLGGAFNVVKYLIDEvkvdveareSEtqsrRD-FpSALHLAILRGHFEIAHFLISRGANMNA 276
                 89**9989*******5544555575526779*******************9666665554411444344.359******************99***998 PP

       Ank_2  82 k 82 
                 +
  EFC35995.1 277 T 277
                 6 PP

  == domain 4  score: 31.7 bits;  conditional E-value: 4.9e-11
       Ank_2   8 gnlelvklLleg........adpn..k.ngktaLhyAakngnleivklLleh...............adndgrtpLhyAarsghleivklLlekgadin 80 
                 g +++++++l++        a  n  + n+++ Lh+   +g +e++++ +++                + +g tpLh+A++ g+ +i+  L++ gadi 
  EFC35995.1 391 GCDQIFEWILNHfysdrqklA--NlrDkNKNNMLHWISGYGRVEMLEIAISYmsedssmdvhvmmnqKNLSGDTPLHVASQLGRKDICTKLIDLGADIR 487
                 444688888844333333222..23325899*************988888755555665555653332255*********99**********99****9 PP

       Ank_2  81 lkd 83 
                 +++
  EFC35995.1 488 VRN 490
                 875 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       3.3   1.2e+04       7      23 ..      16      34 ..      12      35 .. 0.66
   2 ?    2.0   0.0      0.12   4.4e+02       2      23 ..      65      87 ..      64      91 .. 0.83
   3 !   12.2   0.0     6e-05      0.21       2      30 ..     173     201 ..     172     202 .. 0.93
   4 !    8.0   0.0    0.0014       4.9       3      30 ..     209     236 ..     207     237 .. 0.88
   5 !   16.6   0.1   2.3e-06    0.0083       4      28 ..     250     273 ..     249     276 .. 0.92
   6 ?   -3.0   0.0         5   1.8e+04      14      25 ..     392     403 ..     389     406 .. 0.71
   7 ?    4.2   0.0     0.025        91       2      23 ..     418     439 ..     417     449 .. 0.84
   8 !   15.7   0.0   4.4e-06     0.016       2      30 ..     460     487 ..     459     488 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 3.3
       Ank_3  7 hlAarsgnle..ivkfLle 23
                hl ++  n e  i+k L+e
  EFC35995.1 16 HLLCETPNAEskILKSLIE 34
                6677777775557777776 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.12
       Ank_3  2 GetpLhlAarsgnle.ivkfLle 23
                G  p+h+A+ ++  e + + L++
  EFC35995.1 65 GLQPIHTACFFNESEeLFRELVR 87
                6679*******999768888876 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 6e-05
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 G +++ +A+++++l +vk +le+ ++dvn
  EFC35995.1 173 GVSLINYACKYNRLHLVKKMLEKSNIDVN 201
                 678999**********************9 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0014
       Ank_3   3 etpLhlAarsgnleivkfLlenkgadvn 30 
                  +pL  A++ g +++vk+L+++  +dv 
  EFC35995.1 209 HNPLTSAVLGGAFNVVKYLIDEVKVDVE 236
                 68999****************8888875 PP

  == domain 5  score: 16.6 bits;  conditional E-value: 2.3e-06
       Ank_3   4 tpLhlAarsgnleivkfLlenkgad 28 
                 ++LhlA++ g++ei++fL+  +ga+
  EFC35995.1 250 SALHLAILRGHFEIAHFLIS-RGAN 273
                 79******************.9998 PP

  == domain 6  score: -3.0 bits;  conditional E-value: 5
       Ank_3  14 nleivkfLlenk 25 
                 +  i +++l+++
  EFC35995.1 392 CDQIFEWILNHF 403
                 556899999965 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.025
       Ank_3   2 GetpLhlAarsgnleivkfLle 23 
                  +++Lh+   +g++e+++  + 
  EFC35995.1 418 KNNMLHWISGYGRVEMLEIAIS 439
                 6899***********9887665 PP

  == domain 8  score: 15.7 bits;  conditional E-value: 4.4e-06
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 G tpLh+A   g+ +i+  L++  gad++
  EFC35995.1 460 GDTPLHVASQLGRKDICTKLID-LGADIR 487
                 89********************.****97 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.28   9.9e+02      12      24 ..      61      73 ..      54      93 .. 0.73
   2 !   11.6   0.2   7.4e-05      0.26      16      49 ..     173     207 ..     167     212 .. 0.85
   3 !    9.0   0.0   0.00048       1.7      13      49 ..     209     242 ..     199     248 .. 0.80
   4 !   13.3   0.1   2.2e-05     0.079      18      47 ..     250     279 ..     243     287 .. 0.79
   5 !   10.5   0.0   0.00017      0.59       8      36 ..     410     438 ..     406     451 .. 0.86
   6 !   13.4   0.0     2e-05     0.073      11      46 ..     455     490 ..     447     496 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.28
       Ank_5 12 ldgggntpLhvAa 24
                ++ +g  p+h+A+
  EFC35995.1 61 TNSRGLQPIHTAC 73
                6777888899988 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 7.4e-05
       Ank_5  16 gntpLhvAakygaadvvrlLl.argadlnltdsrG 49 
                 g++ +++A+ky+++ +v+++l + + d nl  +++
  EFC35995.1 173 GVSLINYACKYNRLHLVKKMLeKSNIDVNLHVDNY 207
                 7899*****************99999999876665 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00048
       Ank_5  13 dgggntpLhvAakygaadvvrlLl.argadlnltdsrG 49 
                      +pL  A+ +ga++vv++L+ +  +d  +++s+ 
  EFC35995.1 209 H----NPLTSAVLGGAFNVVKYLIdEVKVDVEARESET 242
                 2....9******************98888888888775 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 2.2e-05
       Ank_5  18 tpLhvAakygaadvvrlLlargadlnltds 47 
                 ++Lh+A+ +g+++++ +L+ rga+ n+t++
  EFC35995.1 250 SALHLAILRGHFEIAHFLISRGANMNATCK 279
                 69*****************66666666554 PP

  == domain 5  score: 10.5 bits;  conditional E-value: 0.00017
       Ank_5   8 dvnrldgggntpLhvAakygaadvvrlLl 36 
                   n +d+++n+ Lh+ + yg+ +++++ +
  EFC35995.1 410 LANLRDKNKNNMLHWISGYGRVEMLEIAI 438
                 5689999999***************9987 PP

  == domain 6  score: 13.4 bits;  conditional E-value: 2e-05
       Ank_5  11 rldgggntpLhvAakygaadvvrlLlargadlnltd 46 
                  ++  g tpLhvA+  g+ d++ +L++ gad+++++
  EFC35995.1 455 QKNLSGDTPLHVASQLGRKDICTKLIDLGADIRVRN 490
                 5666777***************************98 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.012        43      14      51 ..      47      82 ..      27      86 .. 0.74
   2 !   15.9   0.1   4.1e-06     0.015       4      55 .]     176     228 ..     173     228 .. 0.93
   3 !   16.2   0.0   3.2e-06     0.011       3      30 ..     250     277 ..     242     290 .. 0.80
   4 ?    4.3   0.0     0.017        62       3      53 ..     377     436 ..     375     438 .. 0.83
   5 !   16.3   0.0   3.2e-06     0.011       5      55 .]     422     480 ..     418     480 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.012
       Ank_4 14 lelvrlLlekgadinaqdnrsGetalhiAakrg.nveil 51
                +++v+ L+ k  ++  + n++G+ ++h A+ ++ + e +
  EFC35995.1 47 MPSVKDLVKK--SLFGT-NSRGLQPIHTACFFNeSEELF 82
                5556666643..44466.999*********887566655 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 4.1e-06
       Ank_4   4 aLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55 
                 ++ ya++++rl lv+  lek ++d+n   +++  ++l  A+++g ++++k+L+
  EFC35995.1 176 LINYACKYNRLHLVKKMLEKsNIDVNLHVDNYYHNPLTSAVLGGAFNVVKYLI 228
                 6679**************9979****99899999******************8 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 3.2e-06
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaq 30 
                 +aLh a+  g++e++++L+++ga+ na+
  EFC35995.1 250 SALHLAILRGHFEIAHFLISRGANMNAT 277
                 5788888888888888888888888887 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.017
       Ank_4   3 taLhyaai.....sgrlelvrlLlekgad.....inaqdnrsGetalhiAakrgnveilkl 53 
                 +++  a+      +g+ ++ +++l++  +      n + +++ ++ lh     g+ve+l+ 
  EFC35995.1 377 EPIWFAIRtignkQGCDQIFEWILNHFYSdrqklANLR-DKNKNNMLHWISGYGRVEMLEI 436
                 567677777778899999999***99866688889999.9********9999999999975 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 3.2e-06
       Ank_4   5 LhyaaisgrlelvrlLl.....ekgadinaq...dnrsGetalhiAakrgnveilklLl 55 
                 Lh+   +gr+e++++ +     ++ +d++     +n sG+t+lh A + g+++i   L+
  EFC35995.1 422 LHWISGYGRVEMLEIAIsymseDSSMDVHVMmnqKNLSGDTPLHVASQLGRKDICTKLI 480
                 899999***********767655677755555556************999999987775 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       4.3   1.5e+04       5      21 ..      68      85 ..      67      88 .. 0.67
   2 ?   -0.2   0.1      0.47   1.7e+03       6      29 ..     177     202 ..     172     206 .. 0.70
   3 ?    2.0   0.0      0.09   3.2e+02       5      27 ..     211     235 ..     208     240 .. 0.71
   4 !   20.5   0.2   1.3e-07   0.00045       4      30 ..     250     277 ..     250     279 .. 0.92
   5 !   20.2   0.0   1.6e-07   0.00058       2      30 ..     460     489 ..     459     490 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 4.3
                HHHHHH.HHTTHHHHHHH CS
         Ank  5 PLHlAa.tngkkriiklL 21
                P H A+  n +++  ++L
  EFC35995.1 68 PIHTACfFNESEELFREL 85
                889999655555555555 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.47
                 HHHHHHHTTHHHHHHHH.TT.TSTTC CS
         Ank   6 LHlAatngkkriiklLL.hG.Anlna 29 
                   +A+ ++ ++ +k  L ++  ++n+
  EFC35995.1 177 INYACKYNRLHLVKKMLeKSnIDVNL 202
                 55899999888999888743366765 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.09
                 HHHHHHHHTTHHHHHHHHTT..TST CS
         Ank   5 PLHlAatngkkriiklLLhG..Anl 27 
                 PL  A+ +g  +++k+L++    ++
  EFC35995.1 211 PLTSAVLGGAFNVVKYLIDEvkVDV 235
                 899999666688*****94322555 PP

  == domain 4  score: 20.5 bits;  conditional E-value: 1.3e-07
                 BHHHHHHHHTTHHHHHHHH.TTTSTTCB CS
         Ank   4 TPLHlAatngkkriiklLL.hGAnlnal 30 
                 ++LHlA+ +g+ +i+++L+ +GAn na+
  EFC35995.1 250 SALHLAILRGHFEIAHFLIsRGANMNAT 277
                 69*****************779****97 PP

  == domain 5  score: 20.2 bits;  conditional E-value: 1.6e-07
                 SBBHHHHHHHHTTHHHHHHHHT.TTSTTCB CS
         Ank   2 GnTPLHlAatngkkriiklLLh.GAnlnal 30 
                 G+TPLH+A++ g k+i+  L++ GA++  +
  EFC35995.1 460 GDTPLHVASQLGRKDICTKLIDlGADIRVR 489
                 9*******************966***8655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (569 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       652  (0.0363657); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.57
# Mc/sec: 3031.24
//
Query:       EFC35996.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.1e-10   39.7   1.5    1.3e-09   38.4   1.5    1.8  1  TLD       TLD


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.4   1.5     7e-14   1.3e-09       1     112 [.      64     175 ..      64     231 .. 0.75

  Alignments for each domain:
  == domain 1  score: 38.4 bits;  conditional E-value: 7e-14
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnk.kfygdsesflfsl.spkfkvyks...tgknkaylntssdglgfGggqp 94 
                 l++++s+dg+s  ++ +++e++g +++++k++++++fG+++++ +k +++  +++d+esf f + ++++ +++    ++  + y ++s + ++fG    
  EFC35996.1  64 LIFRASRDGFSEVEFRKRCEDQGKIVIIVKSKGGDLFGGYTTETLKLDQRgSNVKDEESFTFRFdDNTLYIFRLmhdHNIHALYRYSSLYLFAFG---- 158
                 69*******************************************7666657999*********9888888988533333366667777779999.... PP

         TLD  95 kfsLwidsslekgtsrhs 112
                  + +w+ ++ +++t ++s
  EFC35996.1 159 -YCFWVCGDANTSTYSSS 175
                 .67777777777655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       384  (0.0214178); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.34s 00:00:00.87 Elapsed: 00:00:00.53
# Mc/sec: 1322.83
//
Query:       EFC35997.1  [L=234]
Description: hypothetical protein NAEGRDRAFT_82322 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (234 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       582  (0.0324614); expected 358.6 (0.02)
Passed bias filter:                      259  (0.0144459); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1585.56
//
Query:       EFC35998.1  [L=220]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.6e-23   82.7   4.6    3.8e-23   82.1   4.6    1.2  1  Ribosomal_S3Ae  Ribosomal S3Ae family
  ------ inclusion threshold ------
      0.034   13.7   0.6      0.067   12.8   0.1    1.6  2  LBP_BPI_CETP    LBP / BPI / CETP family, N-terminal domain


Domain annotation for each model (and alignments):
>> Ribosomal_S3Ae  Ribosomal S3Ae family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.1   4.6   4.2e-27   3.8e-23      36     161 ..      76     209 ..      61     216 .. 0.90

  Alignments for each domain:
  == domain 1  score: 82.1 bits;  conditional E-value: 4.2e-27
                     --BSSSESHHSHTT-EEEEESHHHHTCS.HTSSSEEEEEEEEEEE.SSEEEEEEEEEEE-HHHHHHH--SSB-EEEEEEEEEESSSEEEEEEEEE CS
  Ribosomal_S3Ae  36 rtqgtkiaseklkgrvvevslaDLtnde.keqafrklklkieevq.gknaltnFkgmeltrDklrslvrkwsslIeaivdvktkDgyllrvfvva 128
                     +t ++  + ek+ +r++evs  D+  +  +e  +  + lki+++   ++a t+F+g +lt+Dkl  l+++ +s+I+ +++ k  Dgy++r+f++a
      EFC35998.1  76 KTVNHTPTFEKVLNRTLEVSAPDIMPSIkEEMNYNIVNLKINNIPiPQHADTEFNGFRLTKDKLATLTKRFHSTITLNHEFKSLDGYKIRIFMIA 170
                     44445566899************99888777889999******973679********************************************** PP

                     EE-ST.T.....B---HHHHHHHHHHHHHHHHHHHHHS- CS
  Ribosomal_S3Ae 129 fTkkr.n.....sYakssqkkaIrkkmveilteeaseld 161
                      T+ +       sYa++sq+k+Ir +m++++++++s+++
      EFC35998.1 171 STRMKaLqfkktSYANKSQIKKIRTVMTDVISKKISQMK 209
                     ***995379***************************987 PP

>> LBP_BPI_CETP  LBP / BPI / CETP family, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   7.5e-06     0.067      11      53 ..      86     123 ..      83     130 .. 0.89
   2 ?   -3.0   0.0      0.56     5e+03     145     157 ..     193     205 ..     182     213 .. 0.49

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.5e-06
                   HHHHHHHHTS-CCCEEEEEEETTTECEEEEEEEEEEEEEEEEE CS
  LBP_BPI_CETP  11 kvlqkeleklqlpdilgeekikllgkvkynisnlkIsnlqlps 53 
                   kvl+++le ++ pdi+ ++k++    ++yni nlkI+n  +p+
    EFC35998.1  86 KVLNRTLE-VSAPDIMPSIKEE----MNYNIVNLKINNIPIPQ 123
                   67888888.***********66....79**********99998 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.56
                   HHHHHHHHHHHHH CS
  LBP_BPI_CETP 145 lkkvlesqlCpvi 157
                   ++ v+ + + ++i
    EFC35998.1 193 IRTVMTDVISKKI 205
                   3333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.38u 0.24s 00:00:00.62 Elapsed: 00:00:00.40
# Mc/sec: 1646.20
//
Query:       EFC35999.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00065   19.0   0.3     0.0037   16.5   0.1    1.9  2  Peptidase_M56    BlaR1 peptidase M56
     0.0047   17.2   4.7      0.011   16.0   1.0    2.3  2  Orf78            Orf78 (ac78)
     0.0063   16.0   3.9      0.056   12.9   0.4    2.2  2  Nodulin-like     Nodulin-like
     0.0069   16.0   0.3        1.8    8.1   0.1    2.2  2  CD34_antigen     CD34/Podocalyxin family
  ------ inclusion threshold ------
      0.034   12.9   0.1      0.048   12.4   0.1    1.2  1  DUF2207          Predicted membrane protein (DUF2207)
      0.052   13.6   0.2        3.2    7.8   0.0    2.2  2  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe
      0.082   13.5   2.3       0.19   12.3   2.3    1.6  1  Ctr              Ctr copper transporter family
        0.1   13.0   2.2       0.62   10.5   0.5    2.2  2  DUF2663          Protein of unknown function (DUF2663)
       0.16   12.3   4.3        0.5   10.7   0.0    2.5  2  DUF4064          Protein of unknown function (DUF4064)
       0.19   12.6   1.5       0.62   11.0   0.0    2.3  2  EphA2_TM         Ephrin type-A receptor 2 transmembrane domai
       0.28   11.3   3.1         12    6.0   0.1    2.7  3  ETRAMP           Malarial early transcribed membrane protein 
        0.3   11.4   3.9        7.6    6.9   0.6    2.7  2  Sigma_reg_N      Sigma factor regulator N-terminal


Domain annotation for each model (and alignments):
>> Peptidase_M56  BlaR1 peptidase M56
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.18   2.7e+02      88     130 ..      31      71 ..      11      85 .. 0.71
   2 !   16.5   0.1   2.5e-06    0.0037      62     151 ..     142     234 ..     122     237 .] 0.67

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.18
  Peptidase_M56  88 alatdvkkvewktilkillliWivgalilllyliaallvlkkr 130
                    +  +++ k++ k+i   +ll++i  +l+++l  + +l ++  r
     EFC35999.1  31 ENRKEIVKLKAKKI--GILLVVISSCLVCFLLGVGSLYLVATR 71 
                    55556666666666..789999999999999988888777655 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 2.5e-06
  Peptidase_M56  62 tskinsaaskaplasaaskvlddkas....alatdvkkvewktilkillliWivgalilllyliaallvlkkrfvrklgklraeelkeaLkeak 151
                    t +i + +   +++ ++s++  ++a+     +++++++   +t  ++l + +iv++++ + +++  +lvl  +fv ++++ ++++++e++ke +
     EFC35999.1 142 THAITTFNYLKKFTPNNSTICYSNAEetifTFNEPIHTTTISTTQQVLFY-FIVISVLAFCFFMVMVLVLGFYFVERKSEKKDKSQYEEIKEGE 234
                    333333333444444444444444444578999*****999999777765.4555555567777777778877****************99875 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1      0.13   1.9e+02      55      93 ..      36      74 ..      16      82 .. 0.51
   2 !   16.0   1.0   7.2e-06     0.011      42      97 ..     169     224 ..     144     230 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.13
       Orf78 55 naaekaqalnillisllavvcvlvllyv.iyYfvilrerq 93
                  + ka+ +  +l+++++   v+ ll v  +Y v +r  +
  EFC35999.1 36 IVKLKAK-KIGILLVVISSCLVCFLLGVgSLYLVATRLSE 74
                2233333.33455555555555555544145666666555 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 7.2e-06
       Orf78  42 saaeknditekesnaaekaqalnillisllavvcvlvllyviyYfvilrerqkssv 97 
                 ++ + n+  ++++ +++++     ++is+la+   +v++ v+ ++++ r+ +k+ +
  EFC35999.1 169 TIFTFNEPIHTTTISTTQQVLFYFIVISVLAFCFFMVMVLVLGFYFVERKSEKKDK 224
                 333333333333335778888889999999999999999***99999999888765 PP

>> Nodulin-like  Nodulin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.4   3.8e-05     0.056      67     115 ..      48      97 ..      36     103 .. 0.82
   2 ?    4.4   0.2     0.015        22     188     220 ..     178     210 ..     129     224 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.8e-05
  Nodulin-like  67 vvllvgaamg.lvGYgvvwLvvtesiaklpywllfllillaanseawlnT 115
                   +v++ ++  + l+G g ++Lv t+  +++ +  +  +++  + s +++n 
    EFC35999.1  48 LVVISSCLVCfLLGVGSLYLVATRLSEQIDVQYVHNCCFAVGTSYCYMNS 97 
                   34444455552579**********************************96 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.015
  Nodulin-like 188 pkkkeersesavFlvllvisvllavyllvvsil 220
                    +++ ++ ++  F+++ +  +++++++++v +l
    EFC35999.1 178 HTTTISTTQQVLFYFIVISVLAFCFFMVMVLVL 210
                   456667778888999988888888888887776 PP

>> CD34_antigen  CD34/Podocalyxin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.1   0.1    0.0012       1.8     108     138 ..      46      76 ..      20      92 .. 0.69
   2 !    6.1   0.0    0.0048       7.1     108     149 ..     194     232 ..     173     237 .] 0.71

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0012
  CD34_antigen 108 lialvt.sglllaiLlvagyYgclhrRlsksk 138
                   + ++v+ s l+ ++L+v+ +Y  +  Rls + 
    EFC35999.1  46 ILLVVIsSCLVCFLLGVGSLY-LVATRLSEQI 76 
                   4444551456778899*****.7799999765 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0048
  CD34_antigen 108 lialvtsglllaiLlvagyYgclhrRlskskagerLgEelqy 149
                   +i+++     ++++lv g Y  +  R s +k++++  Ee++ 
    EFC35999.1 194 VISVLAFCFFMVMVLVLGFY--FVERKSEKKDKSQ-YEEIKE 232
                   55555555555555556666..689********99.777665 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   3.2e-05     0.048     374     440 ..      30     221 ..      15     231 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.2e-05
     DUF2207 374 kkgkkklkklsalglgliilglilillallllvll................................................................ 408
                  +++k++ kl a  +g++++ +i ++l+++ll+++                                                                
  EFC35999.1  30 GENRKEIVKLKAKKIGILLV-VISSCLVCFLLGVGslylvatrlseqidvqyvhnccfavgtsycymnshdsnyeyceykvsyaklsptivsnpnqfns 127
                 45566666666655555333.33344455555555567778889******************************************************* PP

     DUF2207 409 ..............................................................lvfllilllillliaiivlllfsrllgrrtee 440
                                                                               ++f++i +l++ +++++vl+l  ++++r +e+
  EFC35999.1 128 sfiseqcqqimpsnthaittfnylkkftpnnsticysnaeetiftfnepihtttisttqqvlFYFIVISVLAFCFFMVMVLVLGFYFVERKSEK 221
                 ***********************************************************99999999999999999999999998999998765 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0    0.0022       3.2      27      58 ..      38      69 ..      16      92 .. 0.86
   2 ?    3.8   0.0     0.037        55      37      58 ..     189     210 ..     181     226 .. 0.60

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0022
  Phage_holin_3_6 27 keeakragsgagllgaagvlallalllllval 58
                     k +ak++g++++++   +v+ ll++++l + +
       EFC35999.1 38 KLKAKKIGILLVVISSCLVCFLLGVGSLYLVA 69
                     5599**********************998876 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.037
  Phage_holin_3_6  37 agllgaagvlallalllllval 58 
                      +  +++  vla++ ++++++ l
       EFC35999.1 189 LFYFIVISVLAFCFFMVMVLVL 210
                      4445555555555554444444 PP

>> Ctr  Ctr copper transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   2.3   0.00013      0.19      25     143 ..      51     214 ..      48     217 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00013
         Ctr  25 agsciglfllaifyeflralrerlerewdrhl.a.............rsrekrkaassplvdssssseeeaea.......................... 83 
                 + sc+++fll ++  +l a   rl++++d +  +             +s+ ++ ++ + +v++++ s +                              
  EFC35999.1  51 ISSCLVCFLLGVGSLYLVA--TRLSEQIDVQYvHnccfavgtsycymNSHDSNYEYCEYKVSYAKLSPT---Ivsnpnqfnssfiseqcqqimpsntha 144
                 679*********9988884..455555554443245566777777774444444444444443333333...1334777888999999999999999** PP

         Ctr  84 ............kstsslskseakksvrttpeqqlirallyvvqvllaYilMLlvMtyNvglflavilGagv 143
                             ++++ ++++ +++ +++++   +  +++ + q +l Y++  +v  +   +++ ++lG ++
  EFC35999.1 145 ittfnylkkftpNNSTICYSNAEETIFTFNEP--IHTTTISTTQQVLFYFIVISVLAFCFFMVMVLVLGFYF 214
                 ********997777777777777777777777..*********************************99876 PP

>> DUF2663  Protein of unknown function (DUF2663)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0      0.16   2.4e+02      14      78 ..      38     102 ..      30     125 .. 0.62
   2 ?   10.5   0.5   0.00041      0.62      40      89 ..     182     231 ..     146     233 .. 0.63

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.16
     DUF2663  14 klekrllllsllallvlllfliyvlikssslssllsallessvlllllllvallyvavkllkkKa 78 
                 kl++++  + l+ + + l+ +++ +   + +++ ls  ++ + +    ++v ++y+ ++     +
  EFC35999.1  38 KLKAKKIGILLVVISSCLVCFLLGVGSLYLVATRLSEQIDVQYVHNCCFAVGTSYCYMNSHDSNY 102
                 45554444444444444444444434466667777777777777777777777777777665555 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00041
     DUF2663  40 kssslssllsallessvlllllllvallyvavkllkkKaeKaEk.efhaLr 89 
                  s+++++l+ ++   svl +  ++v++l++ +++++ K+eK++k ++++++
  EFC35999.1 182 ISTTQQVLFYFI-VISVLAFCFFMVMVLVLGFYFVERKSEKKDKsQYEEIK 231
                 244444444444.44555555566666667777777777777652577665 PP

>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   1.6       0.2   2.9e+02      82     102 ..      39      58 ..      36      59 .. 0.67
   2 ?   10.7   0.0   0.00033       0.5      43      82 ..     171     210 ..     120     235 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.2
     DUF4064  82 lkknkkvsGilfiiaailslf 102
                 lk  kk++ +l++i+++l++f
  EFC35999.1  39 LK-AKKIGILLVVISSCLVCF 58 
                 33.455777788899999998 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00033
     DUF4064  43 qalsgedasavleflstllivlgvialiaivlgivgalll 82 
                   +++  ++++ +  +++l++++vi+++a+ ++ v +l+l
  EFC35999.1 171 FTFNEPIHTTTISTTQQVLFYFIVISVLAFCFFMVMVLVL 210
                 6677778888888888888888888888888888888765 PP

>> EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.8       1.6   2.4e+03       7      11 ..      54      58 ..      43     116 .. 0.58
   2 ?   11.0   0.0   0.00041      0.62       2      35 ..     194     227 ..     192     236 .. 0.54

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.6
    EphA2_TM  7 aglvl 11
                  +++
  EFC35999.1 54 CLVCF 58
                11222 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00041
    EphA2_TM   2 iaaavaglvllvilvilvlvlvrrrsknrkqksd 35 
                 +++++a ++++v++++l +++v r+s+++ +++ 
  EFC35999.1 194 VISVLAFCFFMVMVLVLGFYFVERKSEKKDKSQY 227
                 4555555566666667777777555555544432 PP

>> ETRAMP  Malarial early transcribed membrane protein (ETRAMP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.1     0.015        22      18      76 ..       9      63 ..       3      67 .. 0.56
   2 ?   -2.0   0.0       2.6     4e+03      20      20 ..     115     115 ..      79     170 .. 0.55
   3 ?    6.0   0.1     0.008        12       4      45 ..     195     236 ..     193     237 .] 0.84

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.015
      ETRAMP 18 lltpeslcdevnkkkekakkaikkiddkiekkkkkkKliiistiatalallvasalGlg 76
                ll++++++++ +     + ++++  + k   k k kK+ i+ +++++  l+   +lG+g
  EFC35999.1  9 LLAVQCCAEVATI--VREIDETDGENRKEIVKLKAKKIGILLVVISSC-LVC-FLLGVG 63
                6777777777765..555555555555555554666644444444433.333.566665 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.6
      ETRAMP  20 t 20 
                 +
  EFC35999.1 115 S 115
                 1 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.008
      ETRAMP   4 tkvllffafLlavnlltpeslcdevnkkkekakkaikkiddk 45 
                   vl f +f+++v +l    +  +++kk + +  +ik+ +d+
  EFC35999.1 195 ISVLAFCFFMVMVLVLGFYFVERKSEKKDKSQYEEIKEGEDN 236
                 56899999999************9999988888888887776 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.0     0.022        33      13      46 ..      44      77 ..      34     111 .. 0.78
   2 ?    6.9   0.6    0.0051       7.6      15      49 ..     192     227 ..     184     232 .. 0.53

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.022
  Sigma_reg_N 13 lrivlislivlllifvilvvtllylaekegnklr 46
                 + i l++++++l+ f++ v +l  +a+  +++++
   EFC35999.1 44 IGILLVVISSCLVCFLLGVGSLYLVATRLSEQID 77
                 5678888888888888888877777766666664 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0051
  Sigma_reg_N  15 ivlislivlllifvilvvtllyl.aekegnklrevl 49 
                   ++is++++ +++v+ +v++ y+ + k+++k  +++
   EFC35999.1 192 FIVISVLAFCFFMVMVLVLGFYFvERKSEKKDKSQY 227
                  455655555555555555555554555544444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1516  (0.0845557); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.57u 0.26s 00:00:00.83 Elapsed: 00:00:00.44
# Mc/sec: 1603.54
//
Query:       EFC36000.1  [L=205]
Description: mRNA export factor mex67 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-16   58.2   0.5    9.8e-11   41.1   0.2    3.3  3  TAP_C     TAP C-terminal domain
    1.9e-06   27.6   1.3       0.14   12.0   0.3    3.4  3  UBA_4     UBA-like domain
  ------ inclusion threshold ------
      0.049   13.6   0.1      0.075   13.0   0.1    1.3  1  DUF1110   Protein of unknown function (DUF1110)


Domain annotation for each model (and alignments):
>> TAP_C  TAP C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0    0.0002       1.2       2      34 ..      45      77 ..      44      83 .. 0.90
   2 !    5.1   0.0    0.0029        17       4      31 ..      83     111 ..      80     114 .. 0.87
   3 !   41.1   0.2   1.6e-14   9.8e-11       1      49 []     116     164 ..     116     164 .. 0.98

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0002
                HHHHHHHHH-B-HHHHHHHHSSTTT-HHHHHHH CS
       TAP_C  2 mvqafstqtgMnlewsqkcLeqnnWdyerAlqv 34
                m++a+ + tg   e + ++L   +W++e A ++
  EFC36000.1 45 MINALGNYTGESEEKCLRYLIFFGWNFELAYKA 77
                99999999**********************987 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0029
                 HHHHHHH-B.-HHHHHHHHSSTTT-HHHH CS
       TAP_C   4 qafstqtgM.nlewsqkcLeqnnWdyerA 31 
                 q+++++t++ nl  +++ Le++++d + +
  EFC36000.1  83 QELCERTKLsNLFLARRILEEAQFDVTLC 111
                 8999*****78889***********9865 PP

  == domain 3  score: 41.1 bits;  conditional E-value: 1.6e-14
                 HHHHHHHHHH-B-HHHHHHHHSSTTT-HHHHHHHHHHHG..GGS-GGGB CS
       TAP_C   1 emvqafstqtgMnlewsqkcLeqnnWdyerAlqvFeelkakgkIPpeAF 49 
                 e+v  ++++t++ + ++++cL+q +W+++ Alq   el + + +P +AF
  EFC36000.1 116 ELVLYLMNRTNLVHVFAYDCLQQYQWNINSALQRVFELASMNRLPSHAF 164
                 6999********************************************9 PP

>> UBA_4  UBA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.0   6.5e-05      0.39      11      32 ..      53      74 ..      46      76 .. 0.96
   2 ?    1.6   0.0      0.04   2.4e+02      18      29 ..      97     108 ..      83     111 .. 0.88
   3 !   12.0   0.3   2.4e-05      0.14      19      38 ..     133     152 ..     132     155 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 6.5e-05
       UBA_4 11 TGadeekArqlLeannWdLerA 32
                TG +eek+ ++L   +W+ e A
  EFC36000.1 53 TGESEEKCLRYLIFFGWNFELA 74
                999*****************98 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.04
       UBA_4  18 ArqlLeannWdL 29 
                 Ar++Le +++d+
  EFC36000.1  97 ARRILEEAQFDV 108
                 9*********98 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 2.4e-05
       UBA_4  19 rqlLeannWdLerAislyFd 38 
                  ++L++ +W+++ A+++ F+
  EFC36000.1 133 YDCLQQYQWNINSALQRVFE 152
                 579****************8 PP

>> DUF1110  Protein of unknown function (DUF1110)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   1.3e-05     0.075     101     150 ..      81     130 ..      73     159 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.3e-05
     DUF1110 101 gdqylaernAlakLreakedaeeAyasvdrCrghLdavllLLdhpelPgV 150
                   q+l er  l +L  a++  eeA   v  C  +++ vl+L+++ +l  V
  EFC36000.1  81 LSQELCERTKLSNLFLARRILEEAQFDVTLCHQRMELVLYLMNRTNLVHV 130
                 568999**************************************999776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.40u 0.21s 00:00:00.61 Elapsed: 00:00:00.39
# Mc/sec: 1566.64
//
Query:       EFC36001.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       526  (0.0293379); expected 358.6 (0.02)
Passed bias filter:                      220  (0.0122706); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1373.05
//
Query:       EFC36002.1  [L=198]
Description: vWFA domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.4e-12   46.6   0.0    6.9e-12   46.0   0.0    1.2  1  VWA_2     von Willebrand factor type A domain
    4.6e-08   33.5   0.0    6.4e-08   33.1   0.0    1.1  1  VWA       von Willebrand factor type A domain
  ------ inclusion threshold ------
      0.027   12.4   0.0      0.031   12.3   0.0    1.1  1  TssR      Type VI secretion system, TssR
      0.047   13.6   0.0      0.081   12.9   0.0    1.4  1  VWA_3     von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.0   0.0   1.5e-15   6.9e-12       1     106 [.      81     190 ..      81     191 .. 0.91

  Alignments for each domain:
  == domain 1  score: 46.0 bits;  conditional E-value: 1.5e-15
       VWA_2   1 lvfvlDtSgSmrngdygptrleaakdaveallksl....pgd.rvglvtfsdg....pevlipltkdkakilnalrnleakgggtnlaaaLqlarkalk 90 
                 lv+v+D +gSm+++      +e ak+ v++++++l    + d r++ v+++d+    + +++p+tkd +k + +++ + a+ gg +  +aL  a  +++
  EFC36002.1  81 LVIVMDCTGSMSGE------IEVAKRTVTTIISTLhekfQSDlRFSAVSYRDHtddyAVKEFPFTKDLNKAKGYINTMSAQ-GGGDHPEALASALYVIN 172
                 79***********8......*************8766556668*********53455799*******************96.999************** PP

       VWA_2  91 krr..kgekrvivlitDg 106
                 +++  k+ k+++v+++D+
  EFC36002.1 173 EMPfnKKGKKIVVWVADA 190
                 **9999**********96 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.1   0.0   1.4e-11   6.4e-08       1     112 [.      80     189 ..      80     195 .. 0.88

  Alignments for each domain:
  == domain 1  score: 33.1 bits;  conditional E-value: 1.4e-11
                 EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHT.BTTTTEEEEEEEESSS....EEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHH CS
         VWA   1 DivfvlDgSgsmgeenfekvkefikklvekle.vgpegtrvglvqfsse....vktefslndysskeellsalnnlkysgggttntgkalkyaleklfk 94 
                 D+v+v+D+ gsm  +++e +k+ + ++++ l    + + r++ v++ ++    +  ef+++++   ++++ ++n+++ +ggg+    +al+ al  + +
  EFC36002.1  80 DLVIVMDCTGSM-SGEIEVAKRTVTTIISTLHeKFQSDLRFSAVSYRDHtddyAVKEFPFTKD--LNKAKGYINTMSAQGGGDH--PEALASALYVINE 173
                 9***********.9999999999999999999448899*********8888889999*****5..589********99999999..99*******9*99 PP

                 HHGTSSTTSEEEEEEEES CS
         VWA  95 ssagaRenakkviilltd 112
                 +  +++   kk+++ ++d
  EFC36002.1 174 MPFNKKG--KKIVVWVAD 189
                 9999544..999988777 PP

>> TssR  Type VI secretion system, TssR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   6.8e-06     0.031     307     379 ..      84     155 ..      69     187 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.8e-06
        TssR 307 vidgssemkkylpqlvnliqsLetkfekssrktsvkfGavvykddrgnkkpgtsslstdykkllsfLekeaks 379
                 v+d   +m+ +++  + ++ ++  ++ + + +++++f+av y+d+++ + + ++ +++d +k    +++++++
  EFC36002.1  84 VMDCTGSMSGEIEVAKRTVTTIISTLHE-KFQSDLRFSAVSYRDHTDDYAVKEFPFTKDLNKAKGYINTMSAQ 155
                 5666666666655555555555555544.44569****************************99999998887 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   1.8e-05     0.081       2      87 ..      80     167 ..      79     185 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.8e-05
       VWA_3   2 evvivvDvsssmsaen....klvkdaLsvalrqLptndkiavllfgtkprplfpgsravsaaelqealqkikelelslgasnlegaLkea 87 
                 ++viv+D + sms+e+     +v   +s + +++++  +++ ++ ++ ++    +      ++l +a+ +i+++++ +g+ +   aL+ a
  EFC36002.1  80 DLVIVMDCTGSMSGEIevakRTVTTIISTLHEKFQSDLRFSAVSYRDHTDDYAVKEFPFT-KDLNKAKGYINTMSA-QGGGDHPEALASA 167
                 79**************66666666666666677777777777777776666654444444.589999999999999.6666655666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (198 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.37u 0.27s 00:00:00.64 Elapsed: 00:00:00.41
# Mc/sec: 1434.89
//
Query:       EFC36003.1  [L=148]
Description: 60 kDA chaperonin-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.05   14.0   0.8        2.4    8.6   0.0    2.5  2  SeleniumBinding  Selenium binding protein


Domain annotation for each model (and alignments):
>> SeleniumBinding  Selenium binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.2    0.0038        69       7      43 ..      13      44 ..       7      51 .. 0.69
   2 ?    8.6   0.0   0.00013       2.4      29      71 ..      50      93 ..      45     103 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.0038
  SeleniumBinding  7 fiittaneiPGvelyylgivsavvesdnvdkil.kale 43
                     +++t an+iP +      ++   ve++++d+++ k ++
       EFC36003.1 13 LLLTDANKIPNL------VINGCVEDEDMDNLVaKKIK 44
                     567888888876......45566888999999833444 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00013
  SeleniumBinding 29 vvesdnvdkilkaleekvkekkglaligfkltai.dgkllGyGt 71
                      v++  +d++lk +++   + k   + +f+++ +   +l+ y t
       EFC36003.1 50 KVNNLGMDDLLKLIHNETSSEKVAQVKTFEIASTrTKNLMQYST 93
                     578889***************************966699***98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (148 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       781  (0.0435607); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.46
# Mc/sec: 971.71
//
Query:       EFC36004.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.017   14.0   0.1       0.02   13.8   0.1    1.1  1  DNA_topoisoIV  DNA gyrase/topoisomerase IV, subunit A


Domain annotation for each model (and alignments):
>> DNA_topoisoIV  DNA gyrase/topoisomerase IV, subunit A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   1.1e-06      0.02     150     213 ..      16      77 ..      11      89 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.1e-06
  DNA_topoisoIV 150 kipphnlkeiidaliallkgeea.ellelvlgPdfptgggiigkeeikeayetgrGkikvrakve 213
                    +i +hn+ke ++++++ l++ee+ ++l+    P+f  ++  + k++i  +y+tg   i+  +++e
     EFC36004.1  16 TILNHNFKESVKNIVSPLSDEEIaQILT--TDPFFFLYQFST-KTNIDPMYITGMDFIEFFQTIE 77 
                    699******************9866654..89*****99998.6778999999977777666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       391  (0.0218082); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 881.11
//
Query:       EFC36005.1  [L=502]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-16   59.0   1.4      5e-16   59.0   1.4    2.1  2  EAF       RNA polymerase II transcription elongation factor
  ------ inclusion threshold ------
       0.14   11.1  14.4       0.29   10.1  14.4    1.4  1  DUF4856   Domain of unknown function (DUF4856)


Domain annotation for each model (and alignments):
>> EAF  RNA polymerase II transcription elongation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.0   1.4   5.5e-20     5e-16       1      92 [.      11     115 ..      11     122 .. 0.88
   2 ?   -3.2   2.0       1.3   1.1e+04      41      41 ..     215     215 ..     158     270 .. 0.57

  Alignments for each domain:
  == domain 1  score: 59.0 bits;  conditional E-value: 5.5e-20
         EAF   1 Ypiklgssllnal..........kssksefvairYnfkPasvdqsk.egtlkqsssenkevsvelsfsdt.FeGseqpa...kekdcvLvfdeetkeft 84 
                 Y i+lg+s+++ +          +ss++ef+++ Y fkP+s ++++ eg+++  +++++ v++++++s   F+G+ +++   + ++c+L++d+++++ft
  EFC36005.1  11 YSIELGDSFSQLTnsssnnssnsSSSNNEFHSLVYKFKPKSLKDNSwEGKIDI-DTSSTIVHLNTNNS-RlFKGTFESYkkpNIHECILIYDKNSNTFT 107
                 99*******987799*******999*****************99999*****9.66566566666553.369999999988889*************** PP

         EAF  85 Lerldstv 92 
                 Le+l++t+
  EFC36005.1 108 LEKLHATI 115
                 *****997 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.3
         EAF  41 k 41 
                 +
  EFC36005.1 215 T 215
                 3 PP

>> DUF4856  Domain of unknown function (DUF4856)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1  14.4   3.2e-05      0.29      26     186 ..      12     186 ..       4     189 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 3.2e-05
     DUF4856  26 lkelissflk.enateaslsamfaneegandfsnaelnlsdk.......slkskvaaSsdyfaantveqaeikkdieslie..........gqvnevfe 106
                 + el +sf++ +   + s ++ ++   ++n+f++  ++   k       + k  + +Ss     nt ++   k ++es+ +          ++++++f+
  EFC36005.1  12 SIELGDSFSQlT---NSSSNNSSNSSSSNNEFHSLVYKFKPKslkdnswEGKIDIDTSSTIVHLNTNNSRLFKGTFESYKKpniheciliyDKNSNTFT 107
                 445555555522...22333333333334455555555555511111114455678888888888999999999999988899999999999999999* PP

     DUF4856 107 nrnreAsaGvaGqvadgdetryvnekGlevaqvfaksllGalllDqilNnyLseavldeaenradndnkvleeGknYTel 186
                  ++ +A++G   q+   ++ +  n + l+ ++ ++++++  +++  i  nyL+++   +++n+ +n+n+ l++  n T +
  EFC36005.1 108 LEKLHATIGALQQID-NNSSSSNNLQNLNNNNSLNNMMMNNIITETITSNYLNNNNNMNNSNNLNNNNNNLNSNMNSTMM 186
                 *********999995.55666788899***************************99999999999999999999998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2118  (0.118133); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.53
# Mc/sec: 2868.09
//
Query:       EFC36006.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0071   16.3   0.4     0.0071   16.3   0.4    2.7  3  SNARE            SNARE domain
  ------ inclusion threshold ------
      0.055   12.6   0.2      0.055   12.6   0.2    2.5  3  AI-2E_transport  AI-2E family transporter
       0.45   10.5  13.8       0.18   11.8   9.7    2.0  2  YscO-like        YscO-like protein
        5.7    5.7  14.5        7.9    5.2  14.3    1.3  1  ALMT             Aluminium activated malate transporter


Domain annotation for each model (and alignments):
>> SNARE  SNARE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.97   4.3e+03       3      12 ..      11      20 ..      11      25 .. 0.82
   2 !   16.3   0.4   1.6e-06    0.0071       1      30 [.     182     211 ..     182     214 .. 0.91
   3 ?   -4.1   3.0       3.8   1.7e+04      41      49 ..     238     246 ..     235     248 .. 0.49

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.97
                HHHHHHHHHH CS
       SNARE  3 vDrIdtnVen 12
                +++I++++++
  EFC36006.1 11 IQNIEYEIQS 20
                799***9875 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 1.6e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       SNARE   1 emvDrIdtnVenaqsnveraqkeLkkavky 30 
                 e+++  ++n+e+a++ +++a++eL+k +k+
  EFC36006.1 182 ELMNMFENNIEQANDCMDQANEELRKLNKK 211
                 678889********************9986 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 3.8
                 XXXXXXXXX CS
       SNARE  41 illilviil 49 
                 +++il++i+
  EFC36006.1 238 LFVILGLII 246
                 344444444 PP

>> AI-2E_transport  AI-2E family transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.2      0.22   9.7e+02      85     107 ..      10      32 ..       2      83 .. 0.57
   2 ?   -0.2   2.5       0.1   4.5e+02      79     120 ..      79     122 ..      54     152 .. 0.60
   3 ?   12.6   0.2   1.2e-05     0.055      76     161 ..     163     251 ..     159     254 .] 0.83

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.22
  AI-2E_transport  85 slpayidslqnilnelpslleel 107
                      +++++  ++q+++++l ++ + +
       EFC36006.1  10 EIQNIEYEIQSFISHLLRESNNN 32 
                      34444444444444444444433 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.1
  AI-2E_transport  79 ltqlvkslpayidslqnilnelpslleele.n.liqalkqslsk 120
                      ++q+++++ ++ ++l++++++l+++ ++ + n  +  ++ + ++
       EFC36006.1  79 IIQFLNHSLNHCKHLLSFTQNLKDRKKFTKnNqSHLLFNENENN 122
                      44444444455566666666666666666533433333333333 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 1.2e-05
  AI-2E_transport  76 iaqltqlvkslpayidslqnilnelpslleelen...liqalkqslskilsnilssilnsllsllasllglilslvlvllllffllldg 161
                      ++q+++l++ ++  +++  +++n ++++ e+ ++   ++++  ++l+k     l+  +n+l +++++ +++++s ++v+l l+++ +d+
       EFC36006.1 163 AIQISELLTAFESKVEEQGELMNMFENNIEQANDcmdQANEELRKLNKKDDTKLPFPYNILPTYVSHFIKYFVSYLFVILGLIIFIYDR 251
                      6899*************************9997444555555556666666666666****************************9997 PP

>> YscO-like  YscO-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1       0.2   8.9e+02     118     155 ..       8      47 ..       2      53 .. 0.76
   2 ?   11.8   9.7     4e-05      0.18      25     127 ..     108     211 ..      89     215 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.2
                 HHHHHHHHHHHHHHHHHHHHHHHHH..HHHHHHHHHHHHH CS
   YscO-like 118 rkeveklekhkeewlkevkkeeekr..eeleqdEiGsvlf 155
                 r+e++ +e + + ++  + +e +++  +e+  dEi + +f
  EFC36006.1   8 RNEIQNIEYEIQSFISHLLRESNNNdmNEIYYDEIDKQIF 47 
                 7899999999999999999987654115777899887777 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 4e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   YscO-like  25 kdkkkaLekEkeklrkleeerdkvkkhkkaKvaq.lreeldkGttsdkikkmkryikvvkeelkqeekkvekQkekVkvAerkvEqareelakkrkeve 122
                 k+++  L   +++ + leee     + +   ++q l ++l   t  +  +  +     ++e l+  e kve+Q e  ++ e ++Eqa+  + +++ e+ 
  EFC36006.1 108 KNNQSHLLFNENENNTLEEEEITNENRNDFIIQQeLMKQLSSSTDLQDAQDTEITAIQISELLTAFESKVEEQGELMNMFENNIEQANDCMDQANEELR 206
                 444444444444455555543333333334456679999999999999999998889999999************************************ PP

                 HHHHH CS
   YscO-like 123 klekh 127
                 kl+k+
  EFC36006.1 207 KLNKK 211
                 **975 PP

>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2  14.3    0.0018       7.9     267     422 ..      11     166 ..       2     208 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0018
        ALMT 267 lrqcaytvealhgcilseiqapeelrkkfkeelqrvslesakvlrelaesvkkmkklskveellkevkvaaeeLqskldskskLlvnsekweaakkkek 365
                 ++ + y+++++ + +l e + ++++++   +e+ +   es++ l+ l+  + + k +s + +   + k+ ++ L+++l++  +Ll  +++ +  kk +k
  EFC36006.1  11 IQNIEYEIQSFISHLLRESN-NNDMNEIYYDEIDKQIFESSNHLNLLKSIIDQSKYSSDQYHQQLHYKSIIQFLNHSLNHCKHLLSFTQNLKDRKKFTK 108
                 55666777777777777654.578999999*********************9999999987788899999************9*999999888888888 PP

        ALMT 366 aeeveekkeeekeseskkeeaeaveeaeseseksllkeskrslklskkesapaee.sl 422
                 +++++   +e+++++ ++ee ++++ +++  +++l+k+ ++s++l+  + ++ +  ++
  EFC36006.1 109 NNQSHLLFNENENNTLEEEEITNENRNDFIIQQELMKQLSSSTDLQDAQDTEITAiQI 166
                 8888877888888888888888888888888888888888888777666555444233 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2620  (0.146132); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 1528.71
//
Query:       EFC36007.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4531  (0.252719); expected 358.6 (0.02)
Passed bias filter:                      753  (0.041999); expected 358.6 (0.02)
Passed Vit filter:                       390  (0.0217525); expected 17.9 (0.001)
Passed Fwd filter:                       180  (0.0100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 2.70u 0.38s 00:00:03.08 Elapsed: 00:00:00.69
# Mc/sec: 1768.68
//
Query:       EFC36008.1  [L=1043]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.5e-40  137.0   4.5    1.7e-39  135.9   4.5    1.6  1  Peptidase_S8  Subtilase family
    1.4e-05   24.8   1.2    6.6e-05   22.6   1.2    2.3  1  DUF3494       Protein of unknown function (DUF3494)


Domain annotation for each model (and alignments):
>> Peptidase_S8  Subtilase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  135.9   4.5   1.9e-43   1.7e-39       1     284 [.     301     643 ..     301     661 .. 0.74

  Alignments for each domain:
  == domain 1  score: 135.9 bits;  conditional E-value: 1.9e-43
                   -TT-EEEEECS-B-TT-TTTGGGEEE..EEEE---TTSG.GGEETT-SS-TT-SC-SSS....HHHHHHHHHH-B........SSSSSB-SSTTSEE CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxx RF
  Peptidase_S8   1 gkgvlvavlDtGvdpshpdlsvttdgerklvdvideegagfngadsettstnwarddngnsieHGthvAGiaaan......apeegekngvapgaki 91 
                   g++ ++ ++D+Gv+ +h+++ ++ +++    +++++++  + ++  + + ++ ++++      HG+h+A+iaa+n      ++ +++  gvap+aki
    EFC36008.1 301 GQNQVIQIIDSGVEVNHCHFFKENENYFTTPNYSNRKI--IFYQPVTLWGDKLDNNG------HGSHCASIAAGNidsndeTNPMKQDTGVAPQAKI 389
                   6889***************9844333332222222222..33444444444444443......****************999*************** PP

                   E......EEE-SSTTSB-HH..HHHHHHHHHHHH.CT-S..........EEEE-EE....SCETTCHHCHHHHHH............HHHHHH.CCT CS
                   x......xxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx..........xxxxxxx....xxxxxxxxxxxxxxx............xxxxxxxxxx RF
  Peptidase_S8  92 l......svkvldtsggsmetgteliraieeaae.dkvd..........vinmslg....estslpktgrsieal............ainravnkkg 155
                   +      s+ ++  s++s  t t+  r+++ + +  ++           ++ ++ g    ++t l ++g ++ ++             + ra+   +
    EFC36008.1 390 YvtdvmrSIFFYVSSLNSYLT-TAYSRQARISSNsWGCAnpftcyydcdCYEYETGkpinDTTCLAQYGVKCCQVcnsydkdastsdSFTRAN--DE 483
                   *66666644444444444433.33333333333323333444455555566666667776666666666666666999999999555444444..39 PP

                   -EEEEE--SS-T-HHEEE-TTCEECTTTSTTCEEEEEES...................TTSSB-TT--B-TT.......-EEEE-S-CCCCCCCCCH CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_S8 156 vlvviSaGNngktgsslqagspvgtpstsknvitvgayt...................tegkiapfSsrGpssdgklkpdivapGgnivstwsrqsn 233
                   +l+v++aGNng   s    g ++ tpstskn++tvga                     + +++a+fS rG+++dg+ kpd+v pG+ i + ++++ +
    EFC36008.1 484 MLIVFAAGNNGHFSS---EGGTILTPSTSKNALTVGAQYahlqeytrfnttpidevlfNHENMAYFSARGNTADGRSKPDVVGPGVLIWAAYNKNVT 577
                   ***********6666...999****************999***********************************************8888888884 PP

                   HHTTTHHEEEE-SHHHCHHHHHHHHHHHHHHHTT.......--HHH...........HHHHHHCCS-EE CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......xxxxx...........xxxxxxxxxxxx RF
  Peptidase_S8 234 nsaglssyqsmsGTSmAsPnaagaaAlllsalpk.......ltpet...........vraallntAqdl 284
                   + + +  ++++sGTSmA+P +ag+aAl++++l +       +   +           v+a+++++Aq +
    EFC36008.1 578 QCTPSVTLTQKSGTSMATPSIAGSAALVRDYLTQnigllsiY---DknpqqsisgslVKAMIIHSAQKM 643
                   4444444999********************88888***6661...344455888888*********976 PP

>> DUF3494  Protein of unknown function (DUF3494)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   1.2   7.4e-09   6.6e-05      75     198 ..     915    1031 ..     824    1041 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 7.4e-09
                  HHHHHSSS-TT-EEE--SB-..TTEEE.ESEEEEESS-EEE-SS-EEEE-TT-TT--EEEEESS-EEE-TT--EEEETT--GGGEEEEESS-EEE-T CS
     DUF3494   75 ynalagrslpditelgagel..ggrtL.apGvYkstsavtittgdltLDaqGdanavwiFqiagtLtvasgssvvLinGAqaknvfWqvggsatlgt 168 
                  y++l++++++  ++++ +++  +g ++ +  vY + ++++  ++++t+  +G+ ++  ++++a++L+ +   ++ +inGA   nv+W ++ s+++  
  EFC36008.1  915 YDQLQSLQCTV-NNMD-QNIpaSGFVFnSNNVYCFPQGLNG-NTKITF--SGS-DGPIVLKLASNLNSN-FITFEFINGATYDNVYWLINNSIAV-- 1002
                  44455554443.4444.444324555524689***999999.55****..666.7889*********99.889*****************99776.. PP

                  T-EEEEEEEESS-EEE-TT-EEEEEEEESS CS
     DUF3494  169 gstfeGtilaqtsitlstgatvnGrllaqt 198 
                  ++ + G+il +  ++++   ++ G+++ + 
  EFC36008.1 1003 NGPIYGNILTKGVVNFNVV-NLYGSIYNLG 1031
                  5789*********999876.6777776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1043 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1490  (0.0831056); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.84u 0.30s 00:00:01.13 Elapsed: 00:00:00.49
# Mc/sec: 6450.49
//
Query:       EFC36009.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.3e-17   61.7   0.1      1e-16   60.5   0.1    1.7  1  RRM_1          RNA recognition motif. (a.k.a. RRM, RBD, or RN
  ------ inclusion threshold ------
       0.11   12.5  27.2       0.14   12.2  27.2    1.1  1  TFIIA          Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.5   0.1   1.1e-20     1e-16       1      69 [.     269     338 ..     269     339 .. 0.97

  Alignments for each domain:
  == domain 1  score: 60.5 bits;  conditional E-value: 1.1e-20
                 EEEESETTTSSHHHHHHHHHTTSCEEEEEEEEE.TTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEE CS
       RRM_1   1 lfVgnLppdvteeeLkelFskfGpiksiklvrd.etgkskgfafVeFeskedAekAlealngkklggrel 69 
                 ++ +nL ++vt+++L ++F+ + +++++ ++rd +t++skgf+f+ F ++ d  +Ale+lngk lg+r+l
  EFC36009.1 269 IYANNLGNEVTDQMLTTFFQSYPSFSKACVIRDkRTNRSKGFGFISFLDSNDYIHALENLNGKYLGNRPL 338
                 5778****************************************************************97 PP

>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2  27.2   1.5e-05      0.14      55     242 ..      38     237 ..       8     310 .. 0.37

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.5e-05
       TFIIA  55 aqspqfvlqlpqslkqalq....asaaaa.sqapastsqslpslvipagksvqsltanssaataatfslpakleppvqipagvtlqtasgqlykvnv.. 146
                 +  +++ ++l+q++ q+l     ++++++ s  p+st+ s +s+  ++++s +s+ta     t +t +  +k++p   ip  +  + +++++++  v  
  EFC36009.1  38 NDLQSKLAKLQQNIAQKLNktgvPPTSTTpSLLPSSTQPSSTSVPPSSSSSTPSKTA----PTPTTITKATKSQP-STIPPPQLSKIQKPHNTTAPVng 131
                 333344444444444444212223333223333333333333333333333333332....22223333322222.22222222222222222222222 PP

       TFIIA 147 .qasgaqqiaaqplqqvvqq..........sqgsaaqssvaalqaqsqqaqalaepqqqlekq..........qqq.qqqqqqqqqqqqvqqqqqe... 220
                   +++a+q +++ l+++             +++s a++++ +++a       l ++q++   +          +q  ++  q +++++q+qqq q+   
  EFC36009.1 132 lGKQVASQ-IQKSLKNTSTPvtsikpnsttTKSSSANNNIINSNAV------LNNNQSNN--NnqsnddnsieKQIyMMDYQRKKESSQIQQQYQQell 221
                 22222222.2223333222123332223232222222222222222......11111111..0111222233322223333333333344444333233 PP

       TFIIA 221 esqqaqqa.sqeqvagsqvessq 242
                 e++qaqq  +++       ++++
  EFC36009.1 222 EHEQAQQElENS-------NKKK 237
                 222222221111.......1111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3367  (0.187796); expected 358.6 (0.02)
Passed bias filter:                      480  (0.0267723); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.79u 0.31s 00:00:01.10 Elapsed: 00:00:00.49
# Mc/sec: 2139.96
//
Query:       EFC36010.1  [L=193]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.2e-07   29.5 112.8      0.026   14.5  37.1    3.1  3  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9  36.9   4.4e-06     0.078      59     110 ..       3      54 ..       1      55 [. 0.41
   2 !    9.2  43.2   6.5e-05       1.2      60     109 ..      50      99 ..      44     105 .. 0.29
   3 !   14.5  37.1   1.4e-06     0.026      60     111 ..      94     145 ..      93     155 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.4e-06
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepe 110
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+
   EFC36010.1   3 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPK 54 
                  3344444444444444444444444444444444444444444444444444 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 6.5e-05
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepep 109
                  +p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p
   EFC36010.1  50 KPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 99 
                  22222222222222222222222222222222222222222222222222 PP

  == domain 3  score: 14.5 bits;  conditional E-value: 1.4e-06
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  +p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC36010.1  94 KPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPQPNPNPNPNPNPNP 145
                  4555556666666666666655666666666666666666666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (193 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       508  (0.028334); expected 358.6 (0.02)
Passed bias filter:                      256  (0.0142785); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.77u 0.31s 00:00:01.08 Elapsed: 00:00:00.50
# Mc/sec: 1154.36
//
Query:       EFC36011.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.4e-25   86.6  14.1      2e-07   30.6   0.7    6.4  8  DUF4116          Domain of unknown function (DUF4116)
    0.00099   18.7   0.0     0.0019   17.8   0.0    1.4  1  Ras              Ras family
  ------ inclusion threshold ------
      0.059   12.7   0.0       0.13   11.6   0.0    1.5  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   0.7   3.4e-11     2e-07      15      49 .]      26      60 ..       8      60 .. 0.77
   2 !   26.4   0.5   6.9e-10   4.1e-06       4      41 ..      40      77 ..      40      87 .. 0.94
   3 !   25.1   0.0   1.8e-09   1.1e-05       1      49 []      62     112 ..      62     112 .. 0.90
   4 !   22.3   0.0   1.3e-08   7.8e-05       1      29 [.      89     117 ..      89     120 .. 0.96
   5 ?    0.2   0.0       0.1   6.2e+02      12      27 ..     126     141 ..     121     148 .. 0.80
   6 !   17.6   0.1   3.9e-07    0.0023      11      47 ..     150     187 ..     144     189 .. 0.87
   7 ?   -1.9   0.0      0.47   2.8e+03      16      42 ..     207     231 ..     193     236 .. 0.64
   8 ?   -2.8   0.0      0.91   5.4e+03      14      23 ..     262     271 ..     256     272 .. 0.81

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 3.4e-11
     DUF4116 15 alkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                +l  +seeL+nDk ++++A+++n ++++y+ e +r
  EFC36011.1 26 ILGQASEELQNDKAFIMEAIEWNYKCYYYLKERMR 60
                45557899**********************98776 PP

  == domain 2  score: 26.4 bits;  conditional E-value: 6.9e-10
     DUF4116  4 ivleavkkngsalkylseeLknDkeivlkAvkqngtal 41
                +++ea++ n ++++yl e++++D++i+l  v + g+ l
  EFC36011.1 40 FIMEAIEWNYKCYYYLKERMRKDRDIALLVVSKEGYML 77
                8******************************9999877 PP

  == domain 3  score: 25.1 bits;  conditional E-value: 1.8e-09
     DUF4116   1 DrEivleavkkngsalkylsee..LknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+i+l +v+k g+ l+  + +  ++ Dke+v++Av ++ +a+ +as +L+
  EFC36011.1  62 DRDIALLVVSKEGYMLEDSDIKhcFSADKEVVKAAVMSSHSAIMFASSKLK 112
                 9*****************555533788********************9986 PP

  == domain 4  score: 22.3 bits;  conditional E-value: 1.3e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkei 29 
                 D+E+v+ av +  sa+ ++s++Lk D+e+
  EFC36011.1  89 DKEVVKAAVMSSHSAIMFASSKLKEDREF 117
                 9***************************9 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.1
     DUF4116  12 ngsalkylseeLknDk 27 
                 ++s ++y+   L++D+
  EFC36011.1 126 DPSLFRYAHLQLRSDI 141
                 7899999999999997 PP

  == domain 6  score: 17.6 bits;  conditional E-value: 3.9e-07
     DUF4116  11 kngsalkylseeLknDkeivlkAvkqngtalsyas.ee 47 
                 +++ +++y+ ++++ D+e vl+ +k+n+ +  ya  +e
  EFC36011.1 150 NFPQCIQYAISNIQGDIEYVLELIKINPLVVLYANwKE 187
                 67899***********************9999987555 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 0.47
     DUF4116  16 lkylseeLknDkeivlkAvkqngtals 42 
                 +  + eeL  D + +l   ++ g++l 
  EFC36011.1 207 ISSIYEEL--DDDYALDSFRIEGYCLQ 231
                 45555666..66666666666666665 PP

  == domain 8  score: -2.8 bits;  conditional E-value: 0.91
     DUF4116  14 salkylseeL 23 
                 ++lk +s+++
  EFC36011.1 262 KCLKDFSDRF 271
                 5899999987 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   3.2e-07    0.0019      71     158 ..     244     353 ..     227     356 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 3.2e-07
                 TESEEEEEEETTBHHHHHTH....H.HHHHHHHHHSTTTSEEEEEEETTTGGG..................G-SS-HHHHHHHHHHHT.SEEEEEBTTT CS
         Ras  71 daegillvyditsresfenv....k.kwveeikrvaeenvpivLvGnKvDlee..................kravsteegeelakelg.lkfletSAkt 145
                 +++ ++++y+i++    +++    + +++ ei+   + n ++++vG+K+D+ +                  k     + g++l++++g + ++ tS ++
  EFC36011.1 244 KCHIFIMCYSISNPVMMNKClkdfSdRFLPEIQPFLDYNRSVLVVGTKSDICDyskpgdfhlgkywnsylcK--KYDSYGKKLSQRMGaVSYVTTSSRE 340
                 67899******9976665542222557899999999999***************************866422..2356799*******99*******99 PP

                 TCTHHHHHHHHHH CS
         Ras 146 nenveeafeellr 158
                   ++ee+ + +++
  EFC36011.1 341 FVGLEELEDLIVK 353
                 9999887666655 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   2.1e-05      0.13     127     210 ..     270     353 ..     263     360 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.1e-05
                      GG-S-HHHHHHHHHHHEEEEEEEEEEEE----SHHHHHHHHHHHH.HHHHHHHHHHS-HHHHHHHHHHHHHS--HHHHHHHHHH CS
  Ubie_methyltran 127 rnvtDklkaLkeayrvlkpGGrlvvlefskvelpllsqayelyskevlPvlGkllakdldsyryLvesirafPdqetlkelied 210
                      r +++++  L   + vl +G +  + ++sk+  + l + ++ y  +     Gk l++ +   +y++ s r+f + e+l++li +
       EFC36011.1 270 RFLPEIQPFLDYNRSVLVVGTKSDICDYSKPGDFHLGKYWNSYLCKKYDSYGKKLSQRMGAVSYVTTSSREFVGLEELEDLIVK 353
                      566777888888899******************************************************************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       510  (0.0284455); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.25s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 2500.78
//
Query:       EFC36012.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.2e-13   49.6   0.0    4.8e-13   49.4   0.0    1.1  1  NAD_binding_10  NAD(P)H-binding
    8.9e-08   32.0   0.0      1e-07   31.8   0.0    1.0  1  NmrA            NmrA-like family
      3e-06   26.9   0.0    4.1e-06   26.4   0.0    1.2  1  Epimerase       NAD dependent epimerase/dehydratase family
    0.00068   19.1   0.0    0.00089   18.8   0.0    1.1  1  adh_short       short chain dehydrogenase
     0.0095   15.0   0.3      0.012   14.6   0.3    1.1  1  3Beta_HSD       3-beta hydroxysteroid dehydrogenase/isomerase
  ------ inclusion threshold ------
      0.013   14.9   0.0      0.017   14.5   0.0    1.2  1  GDP_Man_Dehyd   GDP-mannose 4,6 dehydratase
      0.015   15.5   0.1      0.025   14.7   0.1    1.3  1  DapB_N          Dihydrodipicolinate reductase, N-terminus
      0.022   14.0   0.1      0.026   13.8   0.1    1.1  1  ATPgrasp_ST     Sugar-transfer associated ATP-grasp


Domain annotation for each model (and alignments):
>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.4   0.0   2.1e-16   4.8e-13       1     107 [.      21     134 ..      21     153 .. 0.86

  Alignments for each domain:
  == domain 1  score: 49.4 bits;  conditional E-value: 2.1e-16
                     TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHHCTTTCEEEE--TT-..CCHHHHHHTT-SEEEES---TCC....HHHH....HHHHHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRnpeklaeleaeeglevvegdvtd..vedlaealkgadaVvsalggggk....deeg....aknivdaa 85 
                     G +Gk G  l+k+l ++ g++ + lvR+++  +e++    ++v++gd+t+  ++d  + l+g+d V+ a+g++++    +  +     k +++aa
      EFC36012.1  21 GISGKLGEVLCKRLCDQ-GFKCKGLVRDEDAKKEVQGLGCTDVFVGDLTKlqTDDFVKYLEGCDFVIDAAGSTSGkdieK--IeftsGKFLAQAA 112
                     558**************.5****************9888899******95448*****************8877655430..2666689999*** PP

                     HHCT--EEEEEEETTTTSGCGC CS
  NAD_binding_10  86 keagvkRfvlvsaigvgdevpg 107
                      +++vk+++ +sa+g+++ + g
      EFC36012.1 113 MKSNVKKYISMSAVGCDHFSSG 134
                     ****************974444 PP

>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.8   0.0   4.6e-11     1e-07       2     107 ..      18     130 ..      17     144 .. 0.87

  Alignments for each domain:
  == domain 1  score: 31.8 bits;  conditional E-value: 4.6e-11
                 EESSTTSHHHHHHHHHHHHHT-EEEEEES-S-SHHHHHHHHSTTEEE.ES-TT..-HHHHHHHHTT-SEEEE---GG......S-HHHHHHHHHHHHHH CS
        NmrA   2 lviGaTGrqGksvvrallkaghkvralvRdtkselakslkeaGvelv.kgdld..dkeslvealkgvdvvfsvtgfy......skeiedgkklvdAake 91 
                  ++G +G++G+ + + l ++g+k + lvRd++  + k+++  G + v  gdl   + +  v+ l+g d v+ + g++      + e   gk l++Aa +
  EFC36012.1  18 FITGISGKLGEVLCKRLCDQGFKCKGLVRDED--AKKEVQGLGCTDVfVGDLTklQTDDFVKYLEGCDFVIDAAGSTsgkdieKIEFTSGKFLAQAAMK 114
                 6899*************************976..5589*******999***99556788**************999899998888999*********** PP

                 HS-SEEEEEE---GG. CS
        NmrA  92 aGvkhfiySslgddnd 107
                   vk++i  s + ++ 
  EFC36012.1 115 SNVKKYISMSAVGCDH 130
                 *******766655554 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.0   1.8e-09   4.1e-06       1     114 [.      17     124 ..      17     136 .. 0.74

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 1.8e-09
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC...EEEE--TT-HH..HHHHHHHHHT-SEEEE--S.---HHHHHHSHHHHHHHHTH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl...elveldltdrs..alerlfkeeqpdavihlAa.vggvaassedpadfieknlq 93 
                 +++tG++G +G  l+k+l ++g ++ gl r+++a+++ +   l   ++  +dlt+ +  ++ ++++  ++d vi +A+  +g         d+ ++ + 
  EFC36012.1  17 VFITGISGKLGEVLCKRLCDQGFKCKGLVRDEDAKKEVQG--LgctDVFVGDLTKLQtdDFVKYLE--GCDFVIDAAGsTSGK--------DIEKIEFT 103
                 68*****************************777765544..255999999999876335555555..********8844433........33335556 PP

                 HHHHHHHHHHHHTCTEEEEEE CS
   Epimerase  94 gtlnlleaarkagvkrllfls 114
                     l++aa k++vk+++ +s
  EFC36012.1 104 SGKFLAQAAMKSNVKKYISMS 124
                 666666666666666666666 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0     4e-07   0.00089       2     125 ..      16     133 ..      15     141 .. 0.76

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 4e-07
                 EEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGGCSHHH CS
   adh_short   2 vvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkeegakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfselseee 100
                 +v++tG s+ +G  ++k+l  +G+k+  + r e+ +++ ++ l+       ++ +D+t+  +++++v+     l++ d ++  AG t  +++++++ + 
  EFC36012.1  16 CVFITGISGKLGEVLCKRLCDQGFKCKGLVRDED-AKKEVQGLGC----TDVFVGDLTKL-QTDDFVKY----LEGCDFVIDAAGSTSGKDIEKIEFTS 104
                 699***********************99888755.5455555554....78999999954.56666655....5999*********7777666655443 PP

                 ....HHHHHHHHTHHHHHHHHHHHHHHHH CS
   adh_short 101 ....wervievNltgvflltravlpamlk 125
                      ++ ++ N++ ++++++   +++ +
  EFC36012.1 105 gkflAQAAMKSNVKKYISMSAVGCDHFSS 133
                 2234577799******9999998888774 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.3   5.4e-06     0.012       2     117 ..      19     126 ..      18     138 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 5.4e-06
   3Beta_HSD   2 vtGgaGFlGralvkeLvrleelkevrvlDlrespelleelskvnvkkviegDvtd..kdkleealegvdvvihlaslvdvagkltedeimkvnvkGTrn 98 
                 +tG +G lG+ l+k+L + +     +   l+ ++  ++e++ ++ ++v  gD+t+  +d+  + leg d vi  a+       ++ + i k+     + 
  EFC36012.1  19 ITGISGKLGEVLCKRLCDQGF----KCKGLVRDEDAKKEVQGLGCTDVFVGDLTKlqTDDFVKYLEGCDFVIDAAGS------TSGKDIEKIEFTSGKF 107
                 89***************9994....666777777777899*************973367899*******99987554......3334588999999999 PP

   3Beta_HSD  99 vleacvkagvrvlvYtSsa 117
                 + +a++k++v++ + +S++
  EFC36012.1 108 LAQAAMKSNVKKYISMSAV 126
                 9999999999998877765 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   7.7e-06     0.017       1      33 [.      18      50 ..      18      68 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 7.7e-06
                   EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlekgyevhgivrrsss 33
                   +iTGi+G  G  l+++L+++g+++ g+vr++++
     EFC36012.1 18 FITGISGKLGEVLCKRLCDQGFKCKGLVRDEDA 50
                   69**************************98765 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.1   1.1e-05     0.025       3      81 ..      17      95 ..      16     108 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.1e-05
                EEEETTTSHHHHHHHHHHHHSTTEEEEEEEETTCSTTTTTBHHHH.SSSS--S-BEBSSHHHHHHH-SEEEE-S-HHHHH CS
      DapB_N  3 vavvGasGrmGkevvkaveeaedlelvaavdrkeselegkdagel.lglgklgvavtddleevlekadvliDFTtpeavl 81
                v ++G+sG++G+ ++k + + ++++  + v  ++ + e + +g   + +g l    tdd+ + le +d +iD    ++ +
  EFC36012.1 17 VFITGISGKLGEVLCKRLCD-QGFKCKGLVRDEDAKKEVQGLGCTdVFVGDLTKLQTDDFVKYLEGCDFVIDAAGSTSGK 95
                789***************99.9****9999999876666667643133447888888999999999******97666555 PP

>> ATPgrasp_ST  Sugar-transfer associated ATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   1.2e-05     0.026      53     125 ..      73     144 ..      33     148 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.2e-05
  ATPgrasp_ST  53 eafvkeleeg..vviKpakgsgGkGilviteredqdylkssgksalldelerhvsnilagLyslggkpdvalvee 125
                  ++fvk l eg  +vi +a + +Gk+i +i + +  ++l++ + + +++++   +s +    +s+g ++d ++ ++
   EFC36012.1  73 DDFVKYL-EGcdFVIDAAGSTSGKDIEKIEF-TSGKFLAQAAMKSNVKKYI-SMSAVGCDHFSSGERKDALVCDK 144
                  4555555.3344*****************88.5566666666666676666.699999999********999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       625  (0.0348597); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1056.86
//
Query:       EFC36013.1  [L=1569]
Description: hypothetical protein NAEGRDRAFT_60066 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      2e-28   98.6   0.1    9.9e-28   96.4   0.1    2.4  1  SPA          Stabilization of polarity axis
    1.7e-09   38.0   1.8    2.1e-08   34.4   1.8    3.1  1  RGS          Regulator of G protein signaling domain
    5.2e-07   29.8   1.5    5.2e-07   29.8   1.5    3.3  3  DENN         DENN (AEX-3) domain
     0.0078   16.4   0.0      0.025   14.8   0.0    1.8  1  L_HMGIC_fpl  Lipoma HMGIC fusion partner-like protein
  ------ inclusion threshold ------
        2.3    8.6   6.4       0.83   10.0   0.8    3.3  3  DED          Death effector domain


Domain annotation for each model (and alignments):
>> SPA  Stabilization of polarity axis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   96.4   0.1   2.8e-31   9.9e-28       2     113 ..     643     758 ..     642     759 .. 0.94

  Alignments for each domain:
  == domain 1  score: 96.4 bits;  conditional E-value: 2.8e-31
         SPA   2 tsllkllekftpeiill.inalltskriivlstkasadevsefvLalsnlispagdvlrgfknnsfPyvdlse....ldalekvpgyIvGvtNPiF... 92 
                 tsl++l+++f+ e++l+ +nall++kri+v+++ a+   vs+++L+l +li+p    +++  n+++Pyv+lse    l+a++k+p+yI+G+tN++F   
  EFC36013.1 643 TSLVQLVQYFGLETMLVcWNALLLDKRIMVIGSPAKL--VSQICLTLPLLIYP----FQYNVNRVHPYVPLSEmddvLSATSKIPEYIIGTTNALFetq 735
                 689**************9*******************..*************9....66666777********9999999****************999 PP

         SPA  93 ..eeqeqlWDvlydldsgsvkls 113
                   ++++q+WDv+++++s++v+l+
  EFC36013.1 736 gkNQRTQWWDVCLSVNSRKVQLA 758
                 99999***************997 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.4   1.8   5.9e-12   2.1e-08       1     100 [.     341     469 ..     341     474 .. 0.96

  Alignments for each domain:
  == domain 1  score: 34.4 bits;  conditional E-value: 5.9e-12
                 -HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.............................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-H CS
         RGS   1 sleslledqpgrslFreFlesefseenlsFwlaveefkka.............................keqeelkkkakeIyneylapsspkelnidk 70 
                 sl+++le+ + r +F+ Fl ++++ e + F+++v+ f+                                + +e k+ka+ I++++l++ s  +++ + 
  EFC36013.1 341 SLKNVLENATMRTFFKAFLSNQYCLEPVIFYEQVKMFRMLcqrrspaspsfeyqmenilahnspssaldLKIQECKQKAEYIIDNFLKDTSMFQIKTSG 439
                 689***********************************999***************************999999************************* PP

                 HHHHHHHHHHCSSSTTTTTTHHHHHHHHHH CS
         RGS  71 klreelekrlekeqpsrklfeeaqeevfel 100
                 kl  +l + +e++  +++lf+++ + + + 
  EFC36013.1 440 KLLRKLFSAIEEKCSDETLFDDILQDIISS 469
                 *************9*********9999875 PP

>> DENN  DENN (AEX-3) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1       1.3   4.8e+03      62      88 ..      24      50 ..      16      56 .. 0.81
   2 !   29.8   1.5   1.5e-10   5.2e-07      64     171 ..     618     735 ..     529     749 .. 0.71
   3 ?   -2.5   0.4       1.1   4.1e+03      35     102 ..    1194    1258 ..    1173    1288 .. 0.62

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.3
        DENN 62 slaveekillqrpedselPledvdlke 88
                + +++++  +q++++s+lP++ ++l++
  EFC36013.1 24 TTSKKQHNNMQSKSTSKLPSKRLSLQT 50
                457889999999*******99999875 PP

  == domain 2  score: 29.8 bits;  conditional E-value: 1.5e-10
        DENN  64 aveekillqrpedsel..Pl...edvdlkelfrcLsienilqlfeavLlErriillSeklarLtsvaealvallyPlkWq....hiyiPvlpaslldvl 153
                  ++++i+l+ p + +   P+   ++++l +l + +++e++l    a+Ll++ri+++ +  +++++++ +l  l+yP++++    h+y+P+  +   dvl
  EFC36013.1 618 PNTDTITLNIPRQIDPftPIaftHGTSLVQLVQYFGLETMLVCWNALLLDKRIMVIGSPAKLVSQICLTLPLLIYPFQYNvnrvHPYVPLSEMD--DVL 714
                 35566666666633333477777899*****************************************************766669999996543..333 PP

        DENN 154 ea..PtP.fiiGvessllele 171
                 +a   +P +iiG ++ l+e++
  EFC36013.1 715 SAtsKIPeYIIGTTNALFETQ 735
                 33113334*******999933 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 1.1
        DENN   35 eaplesfianlllevplPapgktlklvslaveekillqrpedselPledvdlkelfrcLsienilqlf 102 
                    +++++i+++++++    ++++ ++  ++  e  +  + + +e+  ++++++ l+  L++ n+++++
  EFC36013.1 1194 FTEMYHHISSIIMNIKNDLKKSSSVQ--QSEGEDSSDPQTHINEFHHHHMSVY-LLALLQSTNLINII 1258
                  46777788887777665554444444..4444555555555556634666666.78888888888765 PP

>> L_HMGIC_fpl  Lipoma HMGIC fusion partner-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   6.9e-06     0.025      62     137 ..     624     702 ..     592     706 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 6.9e-06
  L_HMGIC_fpl  62 flaipssawkaaavlvalgilllllvlll...slltlcrqsilkksvfkicallqlvaglllllglllyPlgWdseevr 137
                   l+ip ++  ++ +  + g+ l+ lv  +   ++l++ +  +l+k++  i + ++lv+ ++l+l ll+yP+ ++ ++v+
   EFC36013.1 624 TLNIPRQIDPFTPIAFTHGTSLVQLVQYFgleTMLVCWNALLLDKRIMVIGSPAKLVSQICLTLPLLIYPFQYNVNRVH 702
                  4555555544444445555555555544311156667778899*******************************99997 PP

>> DED  Death effector domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1         3   1.1e+04      52      69 ..     580     596 ..     577     606 .. 0.71
   2 ?   -1.8   0.0       1.1   3.9e+03      52      73 ..     814     835 ..     810     838 .. 0.62
   3 ?   10.0   0.8   0.00023      0.83      31      77 ..     896     945 ..     885     949 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3
                 SSTTC-HHHHHHHCTTT- CS
         DED  52 lsednldlLkelLrrikr 69 
                 l+e++l+lL ++ ++i +
  EFC36013.1 580 LNETDLNLLNQVHDQI-N 596
                 7788888888887777.3 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.1
                 SSTTC-HHHHHHHCTTT-HHHH CS
         DED  52 lsednldlLkelLrrikrqdLl 73 
                  +  nl+++ elL + k  d++
  EFC36013.1 814 FKTHNLKFITELLTKGKLTDIV 835
                 5566777777777666555555 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00023
                 S--TT.S.HHHHHHHHHHCTSSSTTC-HHH...HHHHCTTT-HHHHHHCC CS
         DED  31 rklekiksglelfleLekrgllsednldlL...kelLrrikrqdLlkkie 77 
                 ++ ++++s l+l+++L++  ++++++l++L    ++L ++ ++dLl  ++
  EFC36013.1 896 SDDKQSESVLQLLQYLQDDRIIKKQKLKYLfdlDKMLCNVDQIDLLLSVS 945
                 44466799*******************99622267799999999997776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1569 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1564  (0.087233); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.01u 0.32s 00:00:01.33 Elapsed: 00:00:00.50
# Mc/sec: 9451.76
//
Query:       EFC36014.1  [L=159]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-06   26.5   0.0    6.2e-06   25.9   0.0    1.3  1  Ras       Ras family
     0.0034   17.6   0.0     0.0061   16.8   0.0    1.4  1  Roc       Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.081   12.1   0.0       0.21   10.7   0.0    1.7  2  NB-ARC    NB-ARC domain
       0.14   12.7   0.0       0.26   11.8   0.0    1.5  1  ABC_tran  ABC transporter


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.0   1.4e-09   6.2e-06       1      67 [.      92     158 ..      92     159 .] 0.93

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 1.4e-09
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrel 67 
                 K+ ++G+++ GK++l  r ++d+F e +++   ++ ++k+i+v++++ ++e       +ef++lr++
  EFC36014.1  92 KVCVMGEGGAGKSNLCRRCANDDFFEVFDMGTVEEIFRKQISVNNQKFEIEFEEPSSYDEFEALRDM 158
                 899************************997554*********************9999999999987 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   1.4e-06    0.0061       1      41 [.      92     132 ..      92     148 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.4e-06
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEEC CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkev 41 
                 Kv+++G++g+GK+ l++r  +d+f e  +  +  ++++k++
  EFC36014.1  92 KVCVMGEGGAGKSNLCRRCANDDFFEVFDMGTVEEIFRKQI 132
                 99********************9977665555555556665 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.13   5.9e+02     162     191 ..      57      86 ..      50      88 .. 0.84
   2 ?   10.7   0.0   4.7e-05      0.21       8      43 ..      81     113 ..      71     124 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.13
                 HHHHHHHHHCCTS-GGCHH..CHHHHHHHH CS
      NB-ARC 162 deawellenkvfekkleekesleevakeiv 191
                 + ++ ll+++v +k  +++  ++++ +++ 
  EFC36014.1  57 KRCYLLLHKMVEMKFNNDCGAIRNIQHSVQ 86 
                 689********9999999988988888775 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 4.7e-05
                 HHHHHHCTTTSCSEEEEEEESTTSSHHHHHHHHCCS CS
      NB-ARC   8 viekLlekdelqslvvalvGmgGvGKttlakqilnk 43 
                 +++      e++s+ v ++G gG GK+ l +   n+
  EFC36014.1  81 IQHSVQ---ESNSFKVCVMGEGGAGKSNLCRRCAND 113
                 444445...455556***************998887 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   5.8e-05      0.26       9      66 ..      88     137 ..      78     154 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.8e-05
                 ETTSEEEEEESTTSSHHHHHHHHTTSS--...SEEEEEETTCEGGGB-HHHCCHCEEEE-S CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   9 kegekvaivGenGaGKStLlkllagllkp...teGeilldgkdlkeqeleslrkeigvlpq 66 
                 +++ kv ++Ge GaGKS L++  a+       ++G++           +e++rk+i+v  q
  EFC36014.1  88 SNSFKVCVMGEGGAGKSNLCRRCANDDFFevfDMGTV-----------EEIFRKQISVNNQ 137
                 3455899************997776543334455665...........4455555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1039.09
//
Query:       EFC36015.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.16   12.6   4.1        1.8    9.1   0.2    2.1  2  OFCC1     Orofacial cleft 1 candidate gene 1 protein


Domain annotation for each model (and alignments):
>> OFCC1  Orofacial cleft 1 candidate gene 1 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.2    0.0001       1.8      48      91 ..       4      51 ..       1      69 [. 0.75
   2 ?    5.1   0.7    0.0018        33      36      74 ..      94     132 ..      63     151 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0001
       OFCC1 48 kqtseervirkDrldstLaahqqkleleasaeerG...n.esarnyfD 91
                ++++ ++ + kD++ +tL   q+k++ +a+ e r    n +  +nyf 
  EFC36015.1  4 SNKKTKQIMFKDETCKTLNRIQKKVKISAKHELRKqlcNdDLLKNYFV 51
                5667788999********************998852222245688884 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0018
       OFCC1  36 PaFnssstelsakqtseervirkDrldstLaahqqklel 74 
                   +n ++++l +++  +++  + D++ +t+  hqq+++l
  EFC36015.1  94 ANYNHEQNQLFETNIIRNETQQIDETPNTIHNHQQQFDL 132
                 4566666666666666777777788999*******9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1291  (0.0720062); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1028.46
//
Query:       EFC36016.1  [L=147]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.15   11.8   0.1       0.26   11.0   0.1    1.3  1  DUF309    Domain of unknown function (DUF309)
        0.2   10.5   1.3       0.67    8.8   1.3    1.8  1  DUF1729   Domain of unknown function (DUF1729)


Domain annotation for each model (and alignments):
>> DUF309  Domain of unknown function (DUF309)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   2.9e-05      0.26      32      55 ..     121     144 ..     114     146 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 2.9e-05
      DUF309  32 rkllqglIqlAvAlyhlrrgnvrg 55 
                 +++ q l+ql+ Al h ++g++r+
  EFC36016.1 121 QEMNQFLLQLCCALIHQQEGQKRN 144
                 667799***************987 PP

>> DUF1729  Domain of unknown function (DUF1729)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   1.3   7.5e-05      0.67     137     186 ..      11      60 ..       4     142 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 7.5e-05
     DUF1729 137 klwkeldetifsleavekrkaalekkrdeiierlnkdyakpwfavdeege 186
                 k++k +det  +l+  +k+k  +++k++   +  n+d  k +f ++ e +
  EFC36016.1  11 KVIKFMDETCKTLNRIHKKKEKISAKHELRKQLCNHDLLKNYFVLNPEKD 60 
                 78999********999***999999888777788*********9987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (147 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1461  (0.0814881); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.34s 00:00:00.84 Elapsed: 00:00:00.52
# Mc/sec: 847.78
//
Query:       EFC36017.1  [L=134]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        0.4   11.3   6.2       0.39   11.3   4.6    1.7  2  FXMRP1_C_core  Fragile X-related 1 protein core C terminal


Domain annotation for each model (and alignments):
>> FXMRP1_C_core  Fragile X-related 1 protein core C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   4.6   2.2e-05      0.39      54     121 ..      29      95 ..       4     113 .. 0.67
   2 ?    1.1   0.4     0.032   5.8e+02      48      70 ..      99     121 ..      75     129 .. 0.46

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.2e-05
  FXMRP1_C_core  54 ssslggsrsysgRGrGr..RGagatsgkygtnseasnaseteseakdelsdwslagee.eegekesevrsr 121
                    ++++ g+ + ++RGrGr  +G   +  +++++s+++ + +te+ +k ++s+++   ++  + +ke++v+++
     EFC36017.1  29 RKDSNGGEEIMKRGRGRpkKG--DS--SNNYSSNRMIVTKTETLEKWKVSNKKGITKKpPKRKKEKKVLET 95 
                    55666778899******3333..33..46899999999999999999888876544441334444444444 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.032
  FXMRP1_C_core  48 esgessssslggsrsysgRGrGr 70 
                    + +++++ss+  ++s+ +R++ r
     EFC36017.1  99 TLQTNQNSSQLMNKSNFNRNHTR 121
                    23333344444455555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (134 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1185  (0.066094); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 816.14
//
Query:       EFC36018.1  [L=148]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (148 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1404  (0.0783089); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 961.36
//
Query:       EFC36019.1  [L=369]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.14   12.0  10.8      0.039   13.7   7.0    2.1  1  Ephrin_rec_like  Putative ephrin-receptor like
        2.6    8.0   7.1          4    7.5   0.4    2.8  2  cEGF             Complement Clr-like EGF-like


Domain annotation for each model (and alignments):
>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   7.0   4.4e-06     0.039       5      33 ..     275     303 ..     271     318 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 4.4e-06
  Ephrin_rec_like   5 ntgletCipCprgtYqneegqlsClaCP..l 33 
                      +++ + CipC +g Y++  gqlsC+aC   +
       EFC36019.1 275 SAEKKNCIPCAIGEYNP--GQLSCTACTnkP 303
                      467789*********87..9*******8542 PP

>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.4   0.00044         4       5      20 ..     267     282 ..     262     283 .. 0.92
   2 ?    2.8   1.5     0.012   1.1e+02       5      20 ..     321     336 ..     317     336 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00044
                 E-STTEEE.ETTTEEE CS
        cEGF   5 sCppGYkltpdGrsCt 20 
                 sC+pG+  ++  ++C+
  EFC36019.1 267 SCNPGFGFSAEKKNCI 282
                 7**************7 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.012
                 E-STTEEE.ETTTEEE CS
        cEGF   5 sCppGYkltpdGrsCt 20 
                 +C +GY  +++ ++C+
  EFC36019.1 321 ACDDGYDYNASKNTCV 336
                 5**************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (369 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       600  (0.0334653); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.23s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 2553.37
//
Query:       EFC36020.1  [L=246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0021   18.2   1.6     0.0029   17.7   0.8    1.7  2  Podoplanin       Podoplanin
     0.0037   18.2   6.6          4    8.4   0.0    3.1  2  DUF4834          Domain of unknown function (DUF4834)
  ------ inclusion threshold ------
      0.031   14.8   1.1      0.067   13.7   0.4    1.9  2  UK               Virulence determinant
      0.061   13.0   0.0        7.7    6.1   0.0    2.1  2  Wzy_C            O-Antigen ligase
      0.078   12.8   0.4       0.56   10.0   0.1    2.1  2  DUF2157          Predicted membrane protein (DUF2157)
       0.31    9.8   2.7       0.17   10.6   0.2    1.7  2  DUF2207          Predicted membrane protein (DUF2207)
       0.45   11.2   2.6        1.1   10.0   1.7    2.2  2  GRP              Glycine rich protein family
       0.53    9.3   8.7      0.035   13.2   2.8    1.7  2  ABC2_membrane_3  ABC-2 family transporter protein
        4.7    5.9   9.9        1.1    8.0   2.3    2.0  2  O-antigen_lig    O-antigen ligase like membrane protein
        9.2    6.3   6.2         12    5.9   0.1    2.7  2  TMEMspv1-c74-12  Plectrovirus spv1-c74 ORF 12 transmembrane p


Domain annotation for each model (and alignments):
>> Podoplanin  Podoplanin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.8   1.6e-06    0.0029      34     155 ..      59     175 ..      32     178 .. 0.67
   2 ?   -2.7   0.0       3.1   5.6e+03     102     113 ..     203     214 ..     186     221 .. 0.69

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 1.6e-06
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXX-----GGG-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Podoplanin  34 tpgvedekvtpGvednvvttgaseepye.sglttlvptstesvtdlrledlptaestvkakeesqstttlnvvtshstekvgeetettvekdGLatvtL 131
                  p  e +   +G + +     as+++y+ +g++  + + ++  +++ +e +  ae++  a + +q t++l   t  ++ + +++t+t      + + ++
  EFC36020.1  59 FPELEVRELKKGRKKQSDPIQASSNNYNhQGKAQNIQQ-QQGEAETLTEGEVLAEQANTAAQPQQPTSSLPNKTIATKAQLEANTKTM-----IIIFSI 151
                 46666666667765555555556666664888887754.3444444455555555555566777777777666666666788888877.....8999** PP

                 XXXXXXXXXXXXXXXXXXXXXXXX CS
  Podoplanin 132 vgiivGvllaigfiggiiivvvrk 155
                 vg i+  l  ig+i+g+ +vv +k
  EFC36020.1 152 VGCIILGLALIGIIAGVAFVVKQK 175
                 **77766778***********887 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3.1
                 XXXXXXXXXXXX CS
  Podoplanin 102 lnvvtshstekv 113
                 +  +tshs+++ 
  EFC36020.1 203 ARRATSHSKKHD 214
                 556899995433 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   6.7     0.017        30       6      75 ..      12     115 ..       8     126 .. 0.55
   2 !    8.4   0.0    0.0023         4       6      51 ..     146     189 ..     143     234 .. 0.61

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.017
     DUF4834   6 filifiiailviglsilsvilrtv..................................fglgsrkkss...ksaqkqfgnstnsnqqksqsrsetkeeg 67 
                 ++l+ i++++v+ +   s  + +v                                  + +g++k+s     s ++ +++++ +n q++q + et +eg
  EFC36020.1  12 ILLLCILLVVVLLI---SYSIDNVegavkkkkksnkaaetvlivvkknnqfpelevreLKKGRKKQSDpiqASSNNYNHQGKAQNIQQQQGEAETLTEG 107
                 33333333333333...3333333444478889999999999998988898888887777888877765442222222223333333333444445555 PP

     DUF4834  68 eiieeers 75 
                 e+  e+ +
  EFC36020.1 108 EVLAEQAN 115
                 55555544 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0023
     DUF4834   6 filifiiailviglsilsvilrtvfglgsrkkssksaqkqfgnstn 51 
                 +i++ i+ ++++gl++++ i    f + ++++     +++ + s n
  EFC36020.1 146 IIIFSIVGCIILGLALIGIIAGVAFVVKQKRNYP--SSSGAAASSN 189
                 468889999999********99999977665543..2222222322 PP

>> UK  Virulence determinant
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       3.8   6.7e+03      43      64 ..     101     122 ..      72     147 .. 0.59
   2 ?   13.7   0.4   3.8e-05     0.067      50      91 ..     183     224 ..     165     229 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.8
          UK  43 aremtssewiaeywkgikrgnd 64 
                 a  +t  e +ae  +   + ++
  EFC36020.1 101 AETLTEGEVLAEQANTAAQPQQ 122
                 4555666666665555444444 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 3.8e-05
          UK  50 ewiaeywkgikrgndvpcccprkmtsadkkfsvfgkgslirs 91 
                    a      k  n + ccc r+ ts  kk   + +gs   s
  EFC36020.1 183 GAAASSNCCSKLKNLLCCCCARRATSHSKKHDDYENGSSGGS 224
                 34444455567788999***************9999986655 PP

>> Wzy_C  O-Antigen ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0    0.0096        17      46      80 ..      12      69 ..       5     111 .. 0.64
   2 ?    6.1   0.0    0.0043       7.7      41      75 ..     155     189 ..     138     233 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0096
       Wzy_C 46 ilvgvilliilfvlstnletlknitkafgkldkk.......................k 80
                il++ ill++++++s ++ ++   +k  +k +k+                       k
  EFC36020.1 12 ILLLCILLVVVLLISYSIDNVEGAVKKKKKSNKAaetvlivvkknnqfpelevrelkK 69
                5555666666666666666666666555555444555666665555555555555541 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0043
       Wzy_C  41 llllgilvgvilliilfvlstnletlknitkafgk 75 
                 ++l ++l+g+i++++++v +++ +   +   a ++
  EFC36020.1 155 IILGLALIGIIAGVAFVVKQKRNYPSSSGAAASSN 189
                 45666************988888877766666555 PP

>> DUF2157  Predicted membrane protein (DUF2157)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.25   4.4e+02     126     140 ..      12      26 ..       6      53 .. 0.59
   2 ?   10.0   0.1   0.00031      0.56      21      57 ..     136     168 ..     105     171 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.25
     DUF2157 126 llllwalllllmayl 140
                 +lll++ll++++ ++
  EFC36020.1  12 ILLLCILLVVVLLIS 26 
                 334444443333333 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00031
     DUF2157  21 yeaeeresarrrsfleallvlGalllglGlilfvAan 57 
                 ++ e     +++  + +++++G+++lgl+li ++A++
  EFC36020.1 136 AQLEA----NTKTMIIIFSIVGCIILGLALIGIIAGV 168
                 33222....2344599******************985 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.6      0.39   6.9e+02     212     225 ..      12      25 ..       3      45 .. 0.53
   2 ?   10.6   0.2   9.6e-05      0.17     163     239 ..      58     177 ..      26     184 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.39
     DUF2207 212 lilllillllllll 225
                 ++ll+ill+++ll+
  EFC36020.1  12 ILLLCILLVVVLLI 25 
                 22223333322222 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 9.6e-05
     DUF2207 163 pgeglevrvlf........ptn..narktsgnkldeilkeeqk.................................ntreraarlslallillilllil 218
                 +   levr l         p +   ++ +++ k ++i++++++                                  + + +a+++ +++i++i+ +i+
  EFC36020.1  58 QFPELEVRELKkgrkkqsdPIQasSNNYNHQGKAQNIQQQQGEaetltegevlaeqantaaqpqqptsslpnktiaTKAQLEANTKTMIIIFSIVGCII 156
                 444444444445555432211134555555666666666666677888888888888888888888888888888777888888999999999999999 PP

     DUF2207 219 llllllllliklllwkkygre 239
                 l+l+l+ ++  + +  k +r+
  EFC36020.1 157 LGLALIGIIAGVAFVVKQKRN 177
                 999999888887777776655 PP

>> GRP  Glycine rich protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   1.7   0.00061       1.1       6      39 ..      12      47 ..       8     101 .. 0.84
   2 ?   -3.5   0.0       9.6   1.7e+04      62      62 ..     215     215 ..     197     224 .. 0.50

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00061
         GRP  6 lilLglllaavlLissevaaael..skeeksekeee 39
                ++lL +ll++vlLis  + + e   +k++ks+k++e
  EFC36020.1 12 ILLLCILLVVVLLISYSIDNVEGavKKKKKSNKAAE 47
                6899999********999887765555666665554 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 9.6
         GRP  62 g 62 
                 +
  EFC36020.1 215 D 215
                 1 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.6      0.63   1.1e+03     328     343 ..      11      26 ..       6      28 .. 0.63
   2 ?   13.2   2.8     2e-05     0.035      72     189 ..      40     177 ..      25     178 .. 0.57

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.63
  ABC2_membrane_3 328 sliilalfavvyllla 343
                      s+++l+++ vv+ll++
       EFC36020.1  11 SILLLCILLVVVLLIS 26 
                      5666666666666655 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 2e-05
  ABC2_membrane_3  72 kalkngdidgilvipkgfskdll.........kgesatvtvlinssnlnss.kailna...lnsllqqlnasalv.....lqseatstsaninv 147
                      k+ ++   + ++v++k++  + l         k++s+++++ +n+ n +   ++i+++    ++l++ +  ++++     +q+ +     +++ 
       EFC36020.1  40 KKSNKAAETVLIVVKKNNQFPELevrelkkgrKKQSDPIQASSNNYNHQGKaQNIQQQqgeAETLTEGEVLAEQAntaaqPQQPT----SSLPN 129
                      3334445556666677776655589999999988888888888776654333444444322333333333322225433233333....33333 PP

  ABC2_membrane_3 148 estql......eeelsnvasflvgliliilifitasfiavsiveEkes 189
                      +++++      + +++ +   +vg i++ l++i+++  ++++v++k++
       EFC36020.1 130 KTIATkaqleaNTKTMIIIFSIVGCIILGLALIGIIAGVAFVVKQKRN 177
                      33333333355555566666688888888899999999999**99987 PP

>> O-antigen_lig  O-antigen ligase like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   2.3   0.00061       1.1     243     324 ..       9      96 ..       3     131 .. 0.65
   2 ?    2.8   0.9     0.023        40     116     160 ..     134     178 ..     127     212 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00061
  O-antigen_lig 243 kkkklllaiillvligillaiypyspiyrrkelkekeieiksekkeeeeikne.....ikenykseglk......eavleqyeyandkqfsqe 324
                    + + lll+i+l+v+++i+++i +++ ++++k+  +k +e+   + ++++  +e     +     ++g k      +a  ++y+++ + q+ q+
     EFC36020.1   9 NLSILLLCILLVVVLLISYSIDNVEGAVKKKKKSNKAAETVLIVVKKNNQFPElevreL-----KKGRKkqsdpiQASSNNYNHQGKAQNIQQ 96 
                    56677899999999999999999999999998888888876655566666666343332.....22222334445666666666655555444 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.023
  O-antigen_lig 116 kkkelkiekeklikvlliasliysvlilislitgtslktYesesk 160
                    +k +l+ +++ +i ++ i+ +i++ l li +i g+++   ++ ++
     EFC36020.1 134 TKAQLEANTKTMIIIFSIVGCIILGLALIGIIAGVAFVVKQKRNY 178
                    467788899999999999999999999999999998865555555 PP

>> TMEMspv1-c74-12  Plectrovirus spv1-c74 ORF 12 transmembrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.1    0.0069        12      12      42 ..      12      42 ..      10      48 .. 0.83
   2 ?    0.8   2.8      0.27   4.9e+02       6      17 ..     146     159 ..     144     175 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0069
  TMEMspv1-c74-12 12 vivLgiFlyiGLsiyqKikqirgkkkDKKei 42
                     +++L i l + L+i   i  ++g  k KK+ 
       EFC36020.1 12 ILLLCILLVVVLLISYSIDNVEGAVKKKKKS 42
                     57899999999999999****9998888774 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.27
  TMEMspv1-c74-12   6 TtiFSvv..ivLgi 17 
                       +iFS+v  i+Lg+
       EFC36020.1 146 IIIFSIVgcIILGL 159
                      58****88899996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2262  (0.126164); expected 358.6 (0.02)
Passed bias filter:                      826  (0.0460706); expected 358.6 (0.02)
Passed Vit filter:                       100  (0.00557756); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.72u 0.36s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 1411.52
//
Query:       EFC36021.1  [L=516]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.6e-09   36.3   0.9    5.4e-08   33.1   0.9    2.4  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.065   12.6   0.1       0.17   11.2   0.1    1.6  1  Med20     TATA-binding related factor (TRF) of subunit 20 of 


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.1   0.9   6.1e-12   5.4e-08       2     114 ..      32     220 ..      31     224 .. 0.91

  Alignments for each domain:
  == domain 1  score: 33.1 bits;  conditional E-value: 6.1e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.................................................SHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka.................................................keqeelkkkak 51 
                 +e+ ++d++ r +F+ Fl+++ see ++F+++  ++++                                                  k  ++l  +a+
  EFC36021.1  32 FEEAIKDKDCRAIFKRFLKKSRSEELMQFYEEYTKYDELfleclnasssggsggkgrrstttsksdeddtvsnrlsvnsadsstklfrKAIQKLWIQAQ 130
                 678899*******************************************************************************999999999999** PP

                 HHHHHHTSTTSTTSSTS-HHHHHHHHH.HHCSS..........................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHH CS
         RGS  52 eIyneylapsspkelnidkklreelek.rleke..........................qpsrklfeeaqeevfellekdsypkFlksel 114
                 +++ +++++++++e+ni +  r +  + ++ ++                             + lfe +  +v++ l++d++p+F++++l
  EFC36021.1 131 SMIGRFIQQGAEHEINIGSLQRMTFSRwQILDDltpvvfqeanwtdneyqtllnvyqtkLDPNVLFEGLLIAVLQDLKHDQFPRFVRNDL 220
                 *****************98776665541344448999*******************9864455689********************9986 PP

>> Med20  TATA-binding related factor (TRF) of subunit 20 of Mediator complex
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   1.9e-05      0.17      86     129 ..      89     132 ..      70     139 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 1.9e-05
                 ...................EEEE-HSHHHHHHHCT.-SEEE-EE CS
       Med20  86 pektgtnsqqsplvmttvsllsadslfqilleklqslWcqrqtv 129
                 +++t+++s ++  v + +s+ sads+ +++ +++q lW+q q++
  EFC36021.1  89 RSTTTSKSDEDDTVSNRLSVNSADSSTKLFRKAIQKLWIQAQSM 132
                 4456666677889***************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (516 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       824  (0.0459591); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 3229.12
//
Query:       EFC36022.1  [L=433]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      0.009   16.9   0.0      0.019   15.9   0.0    1.5  1  Trypsin_2  Trypsin-like peptidase domain


Domain annotation for each model (and alignments):
>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   1.1e-06     0.019       1     140 [.      89     313 ..      89     320 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.1e-06
   Trypsin_2   1 GsGflvgsdglilTnaHvvdsadgaavkaikkkveeagadgrevpakvvaadp.........................................el.Dl 57 
                 G++f++ +d  ++Tn Hvv+ +++  v    k  +e +++g  ++ ++++++                                          ++ D+
  EFC36022.1  89 GTCFYLLPDV-VITNSHVVNTDQTPFV---YKGTFEEASNGYLQKLNPIERKLlfsgsalqngirkynhsvtrahfpsvddayvdpilslrgdfGYmDV 183
                 89*******9.********77777777...344444444555555554444444444555555555555555555577777788778877665555799 PP

   Trypsin_2  58 Allkv..ssderaglpplplgpsealkggepvyvvGyp.....................lggeksg...............svssGivsgvve...... 112
                  l ++   s+      +l + + + l++++p++ + yp                     +     +               ++s+G+v +         
  EFC36022.1 184 SLHQLkcLSKNLEMSKVLMIPCPTLLQVSDPIFTLHYPgiegyqfsnhkrgecanyfnwA-----PndnvvsnlfhgfgklCISTGKVLAPYAemkden 277
                 999998866666666666677788899999999999987777766665555555555540.....0444445555555555999999999999999999 PP

   Trypsin_2 113 ........sesaasgegesflqtdaatspGsSGGpl 140
                         ++++ +  +++fl t+ ++  GsSGG +
  EFC36022.1 278 gnniwapnTSHQYTSLNSDFLITNESVMMGSSGGCV 313
                 988888887778888888888888888899999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (433 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       438  (0.0244297); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2513.28
//
Query:       EFC36023.1  [L=677]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (677 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1178  (0.0657036); expected 358.6 (0.02)
Passed bias filter:                      587  (0.0327403); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 4184.52
//
Query:       EFC36024.1  [L=685]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0042   17.0   4.7     0.0084   16.0   4.7    1.4  1  nsp8      nsp8 replicase


Domain annotation for each model (and alignments):
>> nsp8  nsp8 replicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   4.7   4.7e-07    0.0084      15      81 ..     603     674 ..     596     680 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 4.7e-07
                 HHHHHHHHHHH......HHCT--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHCCHHHH-HH.HH CS
        nsp8  15 yekakeeyeea......kangssqqelkqlkkalniaksefdrdaavqkklekmaeqaltamykearvedr.ks 81 
                 ye+a++  e+       + + +  + ++ lk a n+a   ++r ++v+++le  ae   ++myk+ r++ + k+
  EFC36024.1 603 YERANQMEENEarkrkmSFSHQKANRVHPLKEARNLA--LYERRKSVEQQLEDFAELESASMYKDDRINPQeKA 674
                 7777665544323221122223345678899999997..7***************************9854155 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (685 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1148  (0.0640303); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.28s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 4272.05
//
Query:       EFC36025.1  [L=557]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.4e-05   24.6   3.0    5.6e-05   23.4   3.0    1.7  1  RGS              Regulator of G protein signaling domain
  ------ inclusion threshold ------
       0.23   12.2   3.6          1   10.1   0.1    2.4  2  PrgI             PrgI family protein
        4.6    7.0   5.6        3.4    7.5   0.5    2.5  2  Phage_holin_2_4  Bacteriophage holin family, superfamily II-l


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   3.0   9.5e-09   5.6e-05       4     117 ..     372     537 ..     369     538 .. 0.89

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 9.5e-09
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...............................................SHHHHHHHHHHHHHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkka...............................................keqeelkkkakeIyn 55 
                 + +ed  +r lF+  +e+e+s en  ++++++ +++                                                + + +  + a+eI+ 
  EFC36025.1 372 DTMEDDGLRALFKVHCEKEKSIENYLLLEKIQYYRTLcersidlqmrlfgqennalsdissdisaesaqsskkkkesplereyaEVEAKKYEVAFEIFT 470
                 5688999*************************************************************************8876566666666****** PP

                 HHTSTTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS  56 eylapsspkelnidkklreelekrleke......qpsrklfeeaqeevfellekdsypkFlkselylr 117
                 e+l+   +  +ni++ l+++++++l k       +  +++f+ +++e++ ++  d +++F +s  ++r
  EFC36025.1 471 EFLEVTGDMAVNISHVLVDSVKDKLDKFndkqieTLPEDMFNILEKETCLVM-MDTHHRFKQSLAFQR 537
                 *************************997777777777788888888877777.477888999988875 PP

>> PrgI  PrgI family protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.9     0.056   3.3e+02      17      43 ..     150     176 ..     146     209 .. 0.75
   2 ?   10.1   0.1   0.00017         1       9      39 ..     317     347 ..     312     372 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.056
        PrgI  17 LtlRQliflvlallvaiglylllrafl 43 
                 Lt   l++l++ l+++igl++l  +++
  EFC36025.1 150 LTSMKLACLLGMLVTVIGLLVLAGVAI 176
                 777788899999888888888877777 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00017
        PrgI   9 yeekiffgLtlRQliflvlallvaiglylll 39 
                  +++ ++g+tl Qli++++ l+v +++++++
  EFC36025.1 317 EKDSQVLGITLVQLIVIAISLFVIMPIIVFV 347
                 48999***************99866665553 PP

>> Phage_holin_2_4  Bacteriophage holin family, superfamily II-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.5   0.00057       3.4      29      49 ..     150     170 ..     142     171 .. 0.90
   2 ?    1.1   0.5     0.054   3.3e+02       5      36 ..     175     207 ..     173     212 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00057
  Phage_holin_2_4  29 lasselialvGlavAliGlLv 49 
                      l+s +l+ l+G++v +iGlLv
       EFC36025.1 150 LTSMKLACLLGMLVTVIGLLV 170
                      678999**************9 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.054
  Phage_holin_2_4   5 tiealaaagnkatgg.GavvsfaGflasselia 36 
                      +i a a+a+ kat +  av+ +     ss+++ 
       EFC36025.1 175 AIAAFATASTKATDIlIAVGKVTSLFESSNAVV 207
                      68899******9976257777888888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (557 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1535  (0.0856155); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.45
# Mc/sec: 3708.85
//
Query:       EFC36026.1  [L=436]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.2e-46  158.4   0.3    2.6e-46  158.2   0.3    1.0  1  Transferase  Transferase family


Domain annotation for each model (and alignments):
>> Transferase  Transferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.2   0.3   1.5e-50   2.6e-46      19     432 ..      18     431 ..       5     433 .. 0.83

  Alignments for each domain:
  == domain 1  score: 158.2 bits;  conditional E-value: 1.5e-50
  Transferase  19 eqtLkLSilDlllpevivkacyfykknkelsqenvsekLktsLsetLtkfypLAGrLktsesgrlelsCnde..GadFveAeadveLsdlkklepdds 114
                  e   kL ++D l p +  +  + y+ +k  ++ +   +L  +L +tL+ f+ +AGr +++++g+ +++  +e  G++F+ A+a+  L d+ k++ d+ 
   EFC36026.1  18 ETLVKLTVFDNLAPALPFHFQFAYRNEKSEPNFMNATELMSALEKTLSIFPIFAGRTVRNNEGEWFVDIRNEtcGVPFTIAQANFNLDDFDKGDYDQY 115
                  44679**************99*******************************************99998887668******************97777 PP

  Transferase 115 lenllpqlavkkegeaipllavqvTkfkcGgvalgvsvsHaiaDgaSlktfieswaelarge..kkvtvtplfarelllprpeppsv...efdqlelr 207
                   + l  q +  ++     +l +qvT+fkcGgv l   + H+  Dg S  +f++ w +l rge   ++    l++ e ++ ++++  +    + q e++
   EFC36026.1 116 PKDLYTQWKGIQD----APLQIQVTYFKCGGVLLVSELLHQLGDGDSHAQFLHRWSQLFRGEsiDNIRYDCLNRNEVIKVSNKESPKsfpFWTQSEEH 209
                  7777764443333....389******************************************777788888888888888833333325233344444 PP

  Transferase 208 kfsasettevkevvtkkivleklsaskleeLkkkasdesngkpa....trfesvtallWrcavkarkldesketvlgiavdiRsrlepklpeeyfGNa 301
                  +  ++ +++  + + k i +     ++l+ +kk a ++ +   a    ++ +++++++W++++kar+l++s+++ l+ + ++R+ l+   +++yfG +
   EFC36026.1 210 INYEELYAKIGQCTAKMIKFS---EKELQAMKKEAMSSIELSNAnswiSTNDALCSHMWKLITKARNLSNSQTSCLLHSCNVRKPLN--IQKDYFGYL 302
                  455555666666666666666...6666666666666544333334489***********************************996..899****** PP

  Transferase 302 llsvvvksta.kellseelsrivekvkeavkkaitkeylsseidweenstlkaelvskgkkdgeevtvsswlklplyevdFGwgkPvyvvpvvsskkd 398
                  +++      + + +l  +ls  +     av+++++k++++  idw   s+  +   +++ + g  v  +sw+ + l ++ F   +P++v+   +++ d
   EFC36026.1 303 VMNGQSDRISvESILHSNLSTLAPVSRHAVNRTMDKQHVQDFIDWISVSKKVRPSDMHVLF-GTDVFATSWVAFNLFDLKFSNESPIFVG-EIPTILD 398
                  *9999999998999*********************************98333323333333.36899********************987.68999** PP

  Transferase 399 nkilllpskeddggvevlvtLpeeemskfeeeae 432
                  ++  ++ +  ++g++ v ++L +e+m+ + +++e
   EFC36026.1 399 GVFKIVEGV-EKGSLVVQLSLWREHMERLLKDPE 431
                  996777776.*****************9999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (436 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       547  (0.0305092); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 2551.96
//
Query:       EFC36027.1  [L=820]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      2e-08   34.1   0.6    5.2e-08   32.7   0.6    1.6  1  Guanylate_cyc   Adenylate and Guanylate cyclase catalytic dom
  ------ inclusion threshold ------
       0.98    9.8   5.7       0.23   11.8   1.6    2.0  2  Orf78           Orf78 (ac78)
        9.7    6.6   9.6       0.41   11.0   0.4    3.3  4  T3RM_EcoP15I_C  Type III R-M EcoP15I C-terminal domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   0.6   8.7e-12   5.2e-08       9     168 ..     539     696 ..     535     711 .. 0.78

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 8.7e-12
  Guanylate_cyc   9 vtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskeglkvrv 104
                     +++++ I gf+ + +     ++ +lL + y+++ +l++  kv       d y v+   +   ++ +++ +++   + +  e+ ++e+k+ +++ +
     EFC36027.1 539 SSVMYIKITGFNMIDNTY---DLSNLLSKCYTNILQLCKTMKVDVHTKSVDEYAVIHPDN---ITILETSLKIKSFFNSLNETLTNEKKTPVDLHI 628
                    589*********999866...9********************877666679**9998777...66666666666444444488888999******* PP

  Guanylate_cyc 105 GihtGpvvagviG.akkprydvwGntvnlAsrmestg..kagkiqvseetyellk.eeqfeltergev 168
                    Gi+tG+++ g iG ++++ y ++G++      +  +    + +i v e+ty   k +  f +  ++++
     EFC36027.1 629 GISTGSCLQGNIGnKQMRYYAMFGRSMKCSRDLAYLNsvISTNILVDESTYLNHKaNSRFVFAPVDRY 696
                    *************77788899****9988765554331146788888888888887777777766665 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.6   3.8e-05      0.23      28      89 ..      26      87 ..      15     102 .. 0.69
   2 ?   -2.8   0.1       1.3   7.8e+03      36      64 ..     496     528 ..     479     538 .. 0.43

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.8e-05
       Orf78 28 nddndkaenkkekksaaeknditekesnaaekaqalnillisllavvcvlvllyviyYfvil 89
                +++n +++n++++++++++++i++++s + ++     +l + l  v+ +++l+++ ++ v l
  EFC36027.1 26 TTNNINHNNNNNNNNINNNEEIQSSKSIHDRNPLLGFCLSFRLFLVMLIMILVIATSFSVWL 87
                33444444555556666667777777666667777888999999999999999888887755 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.3
       Orf78  36 nkkekksaaeknditekesn......aaekaqaln 64 
                 + k+++s++ +++++++  +      ++++++++n
  EFC36027.1 496 YLKKENSSYLEEKSSHT--SsfflgvDNNTNNKMN 528
                 22222222222222222..1234555444444444 PP

>> T3RM_EcoP15I_C  Type III R-M EcoP15I C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       1.9   1.1e+04      40      60 ..      90     110 ..      88     116 .. 0.81
   2 ?   -1.0   0.0      0.38   2.3e+03      28      60 ..     400     431 ..     376     458 .. 0.74
   3 ?   -1.6   0.2       0.6   3.6e+03      53      88 ..     580     616 ..     548     621 .. 0.70
   4 ?   11.0   0.4   6.8e-05      0.41      23      88 ..     729     793 ..     723     801 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.9
  T3RM_EcoP15I_C  40 YliekglesealkaLieklde 60 
                     Y+++++ + +++k L++ ++e
      EFC36027.1  90 YVMHQRESIQSTKVLVQTIQE 110
                     888999999999999999983 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.38
  T3RM_EcoP15I_C  28 egYtayliekkLYliekglesealkaLieklde 60 
                     +   +y i+k L +i++++ + ++++L e++++
      EFC36027.1 400 SILIGYAITKPLRIIQSDFAKIEVMSL-EEIER 431
                     556678899999999999999999987.55554 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.6
  T3RM_EcoP15I_C  53 aLiekldedkefniekivlfgysfeskel.releenl 88 
                        + +de + +++++i +++ s+++k+  + l+e l
      EFC36027.1 580 VHTKSVDEYAVIHPDNITILETSLKIKSFfNSLNETL 616
                     4456677777889999999999999776325566555 PP

  == domain 4  score: 11.0 bits;  conditional E-value: 6.8e-05
  T3RM_EcoP15I_C  23 eevdlegYtayliekkLYliekglesealkaLiekldedkefniekivlfgysfeskelreleenl 88 
                     e+ +l++  a+l+ek + +  +++ +e+++ +i  ++e ++ ++++i l+ + +++++ ++++en+
      EFC36027.1 729 ESKKLNDKLAMLCEKFVSMFTNQMADEDVQYMIGLIEELQTYQPDRIKLWDHLIKLSR-KKINENV 793
                     566789999*****************************************99999876.4577776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (820 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1532  (0.0854482); expected 358.6 (0.02)
Passed bias filter:                      520  (0.0290033); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.79u 0.31s 00:00:01.10 Elapsed: 00:00:00.48
# Mc/sec: 5129.17
//
Query:       EFC36028.1  [L=396]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   1.1e-106  348.4  16.4      3e-16   58.9   0.0    7.7  9  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.015   15.3   0.9        4.6    7.3   0.1    3.8  5  Rsbr_N    Rsbr N terminal
       0.11   11.5   0.0        3.5    6.6   0.0    2.7  3  TctC      Tripartite tricarboxylate transporter family recept
       0.18   11.7   3.5        7.6    6.4   0.0    4.0  5  PH_14     PH domain
       0.28   12.3   1.0        1.6    9.8   0.1    2.3  2  DUF3371   Domain of unknown function (DUF3371)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   0.0   5.3e-13   1.9e-09       8      49 .]       2      43 ..       1      43 [. 0.98
   2 !   45.1   0.0   1.6e-15   5.8e-12       4      49 .]      23      68 ..      20      68 .. 0.96
   3 !   47.0   0.0   4.2e-16   1.5e-12       1      47 [.      45      91 ..      45      93 .. 0.96
   4 !   54.1   0.0   2.5e-18     9e-15       1      49 []      70     118 ..      70     118 .. 0.98
   5 !   58.9   0.0   8.4e-20     3e-16       1      49 []      95     143 ..      95     143 .. 0.99
   6 !   31.5   0.0     3e-11   1.1e-07       1      40 [.     120     159 ..     120     166 .. 0.93
   7 !   55.8   0.0   7.6e-19   2.7e-15       5      46 ..     217     258 ..     213     261 .. 0.93
   8 !   58.2   0.2   1.3e-19   4.8e-16       3      49 .]     265     311 ..     263     311 .. 0.96
   9 !   22.2   0.5   2.3e-08   8.3e-05       1      34 [.     313     348 ..     313     350 .. 0.91

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 5.3e-13
     DUF4116  8 avkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                avk+ng+++++++eeLk++  +vl +vk ng +l ++s eL+
  EFC36028.1  2 AVKRNGEVFHHIDEELKRNEAFVLDCVKENGWILTHVSQELK 43
                9***************************************97 PP

  == domain 2  score: 45.1 bits;  conditional E-value: 1.6e-15
     DUF4116  4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                +vl +vk ng++l+++s eLkn+++++++Avk +g a  +  eeLr
  EFC36028.1 23 FVLDCVKENGWILTHVSQELKNNRDFIKRAVKYYGRAVTFTNEELR 68
                9********************************************8 PP

  == domain 3  score: 47.0 bits;  conditional E-value: 4.2e-16
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47
                +r++++ avk +g a ++ +eeL+nDk ivl Av+q+g++l+y+s+ 
  EFC36028.1 45 NRDFIKRAVKYYGRAVTFTNEELRNDKSIVLDAVRQDGYVLRYLSNL 91
                8********************************************86 PP

  == domain 4  score: 54.1 bits;  conditional E-value: 2.5e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+ ivl av+++g++l+yls+ ++nD+e+vl+ vkqng+al +as +Lr
  EFC36028.1  70 DKSIVLDAVRQDGYVLRYLSNLMQNDREVVLESVKQNGIALQFASFKLR 118
                 899******************************************9887 PP

  == domain 5  score: 58.9 bits;  conditional E-value: 8.4e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vle vk+ng al+++s +L+nDke+v +Avkq +++l+yas +Lr
  EFC36028.1  95 DREVVLESVKQNGIALQFASFKLRNDKEVVSEAVKQKPSSLEYASFDLR 143
                 9********************************************9998 PP

  == domain 6  score: 31.5 bits;  conditional E-value: 3e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 D+E+v eavk+ +s+l+y+s +L++D+e++  A+ + +++
  EFC36028.1 120 DKEVVSEAVKQKPSSLEYASFDLRHDRELIDLALAIQPIV 159
                 9********************************9887766 PP

  == domain 7  score: 55.8 bits;  conditional E-value: 7.6e-19
     DUF4116   5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 +l+avkk g +l ++s++LknDkeivl+Avkqn+ a++yas 
  EFC36028.1 217 ILQAVKKEGHYLMFASDRLKNDKEIVLEAVKQNPWAFKYASV 258
                 9***************************************96 PP

  == domain 8  score: 58.2 bits;  conditional E-value: 1.3e-19
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Ei+lea+kkngs lk++s e +nDke+v+ Avkq+g+al+yas+ L+
  EFC36028.1 265 EIILEALKKNGSLLKFCSFEVRNDKELVMVAVKQDGSALKYASDRLK 311
                 9*******************************************996 PP

  == domain 9  score: 22.2 bits;  conditional E-value: 2.3e-08
     DUF4116   1 DrEivleavkkngsalkyls..eeLknDkeivlkAv 34 
                 D+ ivlea+k+  +al++++  + LknD+e+ ++ +
  EFC36028.1 313 DKKIVLEALKQTDKALEFANiqDLLKNDFEFKMELM 348
                 999***************986689*******99987 PP

>> Rsbr_N  Rsbr N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.63   2.3e+03      68      90 ..      30      52 ..      10      66 .. 0.74
   2 ?    2.7   0.0     0.036   1.3e+02      65      94 ..      77     106 ..      42     119 .. 0.74
   3 ?   -1.7   0.0      0.79   2.8e+03      68      93 ..     223     248 ..     185     265 .. 0.60
   4 ?    0.0   0.0      0.23   8.4e+02      68      94 ..     248     274 ..     217     284 .. 0.80
   5 ?    7.3   0.1    0.0013       4.6      68     109 ..     298     339 ..     288     356 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.63
                HTT--HHHHHHHHHHHHHHHHHH CS
      Rsbr_N 68 qlGwpLkyltkgLqefrkvvlel 90
                ++Gw L+ +++ L+  r+ + ++
  EFC36028.1 30 ENGWILTHVSQELKNNRDFIKRA 52
                47888888888888777766555 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.036
                 HHHHTT--HHHHHHHHHHHHHHHHHHHHH. CS
      Rsbr_N  65 rlvqlGwpLkyltkgLqefrkvvlellsee 94 
                  + q G  L yl++ +q  r+vvle ++++
  EFC36028.1  77 AVRQDGYVLRYLSNLMQNDREVVLESVKQN 106
                 44578999***************9999885 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.79
                 HTT--HHHHHHHHHHHHHHHHHHHHH CS
      Rsbr_N  68 qlGwpLkyltkgLqefrkvvlellse 93 
                 + G  L + ++ L+  +++vle++++
  EFC36028.1 223 KEGHYLMFASDRLKNDKEIVLEAVKQ 248
                 34555555555555555555555554 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.23
                 HTT--HHHHHHHHHHHHHHHHHHHHH. CS
      Rsbr_N  68 qlGwpLkyltkgLqefrkvvlellsee 94 
                 q+ w  ky + +Lq+  +++le+l+++
  EFC36028.1 248 QNPWAFKYASVALQKDNEIILEALKKN 274
                 667899999999999999998888875 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.0013
                 HTT--HHHHHHHHHHHHHHHHHHHHH..T--TT--HHHHHHH CS
      Rsbr_N  68 qlGwpLkyltkgLqefrkvvlellseeddvvkeeqslellee 109
                 q G  Lky ++ L++ +k+vle+l+++d+  +  + ++ll++
  EFC36028.1 298 QDGSALKYASDRLKVDKKIVLEALKQTDKALEFANIQDLLKN 339
                 6799***********************988888888888765 PP

>> TctC  Tripartite tricarboxylate transporter family receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0     0.052   1.9e+02      86     114 ..     113     142 ..      76     156 .. 0.76
   2 ?    6.6   0.0   0.00097       3.5      75     128 ..     221     274 ..     204     279 .. 0.72
   3 ?   -1.6   0.0      0.31   1.1e+03      90     128 ..     285     324 ..     276     334 .. 0.72

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.052
        TctC  86 adspfkdlqelva.yakanPgKlsyasaGi 114
                 a +++++ +e+v  ++k+ P  l+yas+ +
  EFC36028.1 113 ASFKLRNDKEVVSeAVKQKPSSLEYASFDL 142
                 667777778888527799999999999865 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.00097
        TctC  75 vatlplvLvvpadspfkdlqe.lvayakanPgKlsyasaGigtslhLaaellask 128
                 v +    L+  +d ++k+ +e +++++k+nP   +yas+ +   +++  e+l+++
  EFC36028.1 221 VKKEGHYLMFASD-RLKNDKEiVLEAVKQNPWAFKYASVALQKDNEIILEALKKN 274
                 4444444555445.5555555157999*******************999999875 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.31
        TctC  90 fkdlqelva.yakanPgKlsyasaGigtslhLaaellask 128
                 +++ +elv  ++k++   l+yas  +    +++ e+l+++
  EFC36028.1 285 VRNDKELVMvAVKQDGSALKYASDRLKVDKKIVLEALKQT 324
                 5566677652568888899999999999999999999764 PP

>> PH_14  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0021       7.6       7      44 ..       5      42 ..       2      53 .. 0.88
   2 ?    0.3   0.0      0.17     6e+02      24      49 ..      72      99 ..      51     154 .. 0.62
   3 ?   -0.6   0.1      0.31   1.1e+03      22      71 ..     167     215 ..     158     227 .. 0.60
   4 ?    1.1   0.1     0.094   3.4e+02      25      48 ..     216     241 ..     204     292 .. 0.71
   5 ?    0.1   0.0      0.19   6.7e+02       4      47 ..     269     313 ..     266     333 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0021
       PH_14  7 qkGekfikwdeestlveplvllkvDkkGfflywksqnk 44
                ++Ge+f + dee   +e  vl  v ++G++l+++sq++
  EFC36028.1  5 RNGEVFHHIDEELKRNEAFVLDCVKENGWILTHVSQEL 42
                58****************99**************9954 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.17
       PH_14 24 plvllkvDkkGfflywksq..nkeievl 49
                 +vl  v ++G+ l + s+  +++ ev+
  EFC36028.1 72 SIVLDAVRQDGYVLRYLSNlmQNDREVV 99
                3677778888998888886545555543 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.31
       PH_14  22 veplvllkvDkkGfflywksq..nkeievleiasirdiRlGklakipKdeKl 71 
                 +++ ++l  D++ f + + ++  +++ie++e+  + di l  ++   Kd+++
  EFC36028.1 167 FNNFNTLASDNQ-FRVSFFDEmnENDIELMEL--MMDISLSSVTDEQKDDRF 215
                 334467776665.7777877633455555554..567777776777777665 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.094
       PH_14  25 lvllkvDkkGfflywksq..nkeiev 48 
                 + l  v k+G +l++ s+  +++ e+
  EFC36028.1 216 TILQAVKKEGHYLMFASDrlKNDKEI 241
                 456679999******99754344443 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.19
       PH_14   4 eklqkGekfikwde.estlveplvllkvDkkGfflywksqnkeie 47 
                 e+l+k   ++k+   e    ++lv++ v ++G  l++ s+ + ++
  EFC36028.1 269 EALKKNGSLLKFCSfEVRNDKELVMVAVKQDGSALKYASDRLKVD 313
                 567777777777764555666789999999999999988865554 PP

>> DUF3371  Domain of unknown function (DUF3371)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   0.00044       1.6       9     101 ..     111     205 ..     103     210 .. 0.67
   2 ?    0.5   0.1      0.35   1.2e+03      17      38 ..     287     308 ..     224     384 .. 0.55

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00044
     DUF3371   9 psaspsglstaellsqvikqetpaleplpqellqqalqpq.splqsaavgssqpldlaqslslseltddgigfsdalkee.skLedlLmddtlsP 101
                   as ++ ++ e++s+++kq+ ++le  + +l ++ +    + + ++ v   qp  +++  +l++ ++  ++f d+++e+  +L +l+md +ls 
  EFC36028.1 111 QFASFKLRNDKEVVSEAVKQKPSSLEYASFDLRHDRELIDlALAIQPIVIWDQPKTFNNFNTLASDNQFRVSFFDEMNENdIELMELMMDISLSS 205
                 5566677799999********8888888777776333333122233445566666666555555556666677777766559********99885 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.35
     DUF3371  17 staellsqvikqetpaleplpq 38 
                 ++ el+  ++kq  +al+  ++
  EFC36028.1 287 NDKELVMVAVKQDGSALKYASD 308
                 3444444444544333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (396 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       960  (0.0535445); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.57
# Mc/sec: 2082.60
//
Query:       EFC36029.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.038   13.8   0.1      0.048   13.5   0.1    1.2  1  DUF4668   Domain of unknown function (DUF4668)


Domain annotation for each model (and alignments):
>> DUF4668  Domain of unknown function (DUF4668)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   2.7e-06     0.048      67     103 ..      65     101 ..      53     105 .] 0.87

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.7e-06
     DUF4668  67 krkpkrCskikcsrcnarkkhPkwFklkywLlfllly 103
                 +  pk C+k + +  +a  ++P++ ++ + ++++l  
  EFC36029.1  65 QLDPKSCTKYNLPLAKAMLQSPNYVQVAFAMYYILQV 101
                 6789****************************99865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       474  (0.0264376); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.55
# Mc/sec: 571.18
//
Query:       EFC36030.1  [L=279]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-05   23.2   0.0    9.8e-05   22.0   0.0    1.5  1  Ras       Ras family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0   5.5e-09   9.8e-05     104     148 ..     182     240 ..     166     246 .. 0.91

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 5.5e-09
                 TSEEEEEEETTTGGG.............G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCT CS
         Ras 104 nvpivLvGnKvDlee.............kravsteegeelakelg.lkfletSAktnen 148
                 + ++v+v +K Dl++             ++ +s+eeg e+ k +g + f+etSAkt e+
  EFC36030.1 182 TATFVVVSTKNDLKDslywnslfysttvDEPISKEEGIEFTKAIGaVSFIETSAKTGEG 240
                 4789*****************************************9*********9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       712  (0.0397122); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1710.41
//
Query:       EFC36031.1  [L=286]
Description: hypothetical protein NAEGRDRAFT_82316 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       543  (0.0302861); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1741.67
//
Query:       EFC36032.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-50  171.3   1.5      2e-50  171.1   1.5    1.0  1  Pro_CA    Carbonic anhydrase


Domain annotation for each model (and alignments):
>> Pro_CA  Carbonic anhydrase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  171.1   1.5   1.1e-54     2e-50       2     155 ..       1     151 [.       1     152 [. 0.96

  Alignments for each domain:
  == domain 1  score: 171.1 bits;  conditional E-value: 1.1e-54
                 EEEEETTTTS-HHHHTTS-TTSEEEEEETTG---TT-HHHHHHHHHHHHTS--SEEEEEEETT-HHHHHHHSHHCCSTTSSHHHHHHHHHHHHHHHCHH CS
      Pro_CA   2 lvigCsDSRvppelitdagpGdlFvvrnvgnlvppadssvlaaleyAvevlkvkhivVlGHskCGavkaalkaekseeeagaidkwlekirealekvee 100
                 ++igCsDSRvpp+++t+++pG++F++rnv+nlv+++d + +++l+yAvevl+vkh++V+GH++CG+v aal++    ++ g id+wl++i+++++ +++
  EFC36032.1   1 MLIGCSDSRVPPDQLTKTQPGQIFIHRNVANLVVNTDVNAMSVLQYAVEVLQVKHVIVMGHTRCGGVMAALTN----KHLGLIDHWLRNIKDVYRLHKA 95 
                 68******************************************************************99985....2379****************** PP

                 HHHTTSSHHHHHHHHHHHHHHHHHHHHHCSHHHHHHHHTTS.-EEEEEEEETTTTE CS
      Pro_CA 101 elesekekearerlleeenVaeqlenLlekpvvreavekgk.lkvhGlvydletGe 155
                 e +++++k+++ +++ e+n+ eq  nL++++vv++a++kg+ l+vhG++ d+etG 
  EFC36032.1  96 EVDAIEDKDKKIHRMIELNIIEQTLNLCKTSVVQNAWAKGRtLHVHGWLCDIETGL 151
                 *9**99999888888*************************99************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       630  (0.0351386); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1112.25
//
Query:       EFC36033.1  [L=494]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-06   28.5   0.0    4.7e-05   23.5   0.0    2.3  1  Peptidase_C92  Permuted papain-like amidase enzyme, YaeF/YiiX


Domain annotation for each model (and alignments):
>> Peptidase_C92  Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   2.6e-09   4.7e-05       2     121 ..     269     438 ..     268     448 .. 0.79

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 2.6e-09
  Peptidase_C92   2 lekGdiifqtsraslseainpatasefkHvgivvgeeg.................derlvveaaake.......gvrvtpLseflar......... 64 
                    l++Gd+++++ +   s+ai+    s ++H +i++++                    +++v+e+ +         g++++ L+++  +         
     EFC36033.1 269 LRTGDVLLHSGKGTFSKAIQLGFSSTWSHLSIIIRNPPkellelykvqvdassrfSTVFVAESETDTvdnkeggGIQLVELRRWFMDylerdptdl 364
                    789******************999***********9999****************6699999965558888888*********9999999899555 PP

  Peptidase_C92  65 ..rssiavyrlkea....ltaeqrqkaaeaalrrlgkpYdfgFele.............ddrlYCsklVakaykea 121
                       +++ +  +++        +q  +++++ +  ++k+Y+++ + e             d +++Cs++Va++y  +
     EFC36033.1 365 ccLRRLNIPSMDNRpkdeNIVDQFPTLVDYLKISIDKKYETS-KSEllkcvikrntqsnDANVFCSEFVAECY-LR 438
                    444444443333332222234566778888889999999998.5445666777777778899***********.43 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (494 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1172  (0.065369); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 3391.06
//
Query:       EFC36034.1  [L=2187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.7e-55  186.8   0.3    1.2e-53  181.4   0.1    2.5  2  Guanylate_cyc    Adenylate and Guanylate cyclase catalytic do
      9e-13   48.4   0.1    3.6e-12   46.4   0.1    2.2  1  PAS_9            PAS domain
      2e-07   31.0   0.1    1.9e-06   27.9   0.0    2.5  2  PAS              PAS fold
    0.00021   21.1   4.5       0.25   11.2   0.2    2.9  2  DUF2153          Uncharacterized protein conserved in archaea
    0.00099   18.9   6.1      0.081   12.7   1.9    2.5  2  TAF1D            TATA box-binding protein-associated factor 1
     0.0076   15.9  12.8      0.085   12.4   0.3    3.3  2  Ni_hydr_CYTB     Prokaryotic cytochrome b561
  ------ inclusion threshold ------
       0.01   15.5   2.1        1.9    8.1   0.0    2.7  2  Transposon_TraM  Conjugative transposon, TraM
      0.065   13.3   0.0       0.17   11.9   0.0    1.6  1  PAS_8            PAS domain
       0.39   11.1   2.5         31    5.1   0.2    2.8  2  DUF2564          Protein of unknown function (DUF2564)
        1.1    9.7   3.3         53    4.4   0.0    3.3  3  DUF668           Protein of unknown function (DUF668)
        7.2    6.6   8.5         39    4.3   1.0    3.6  4  E2               Bacteriophage E2-like protein


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.044        71      18      55 ..    1855    1892 ..    1849    1895 .. 0.90
   2 !  181.4   0.1   7.6e-57   1.2e-53       3     182 ..    1974    2154 ..    1972    2155 .. 0.97

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.044
  Guanylate_cyc   18 gftalssahspievvklLnelyarfdelldekkvykvk 55  
                     +f +l  +hs++++ ++L+++ +++de +++ +v + +
     EFC36034.1 1855 NFMHLFDEHSGEKLSNILKTIKSEIDENVKHGDVIELE 1892
                     8999************************9999887766 PP

  == domain 2  score: 181.4 bits;  conditional E-value: 7.6e-57
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevave 95  
                     ae+++++t +F+d+vgft++ss ++p e+v +L ++++ fd+l+d + ++k+ktiGday +v gl+ +++ +h ++ +++a+d ++ +++ ++e
     EFC36034.1 1974 AERFSDITCFFSDMVGFTKMSSGMNPSELVLMLSSIVNGFDDLTDVYSLEKIKTIGDAYFCVGGLHnNPQSDHPERTLRFAIDTFQVIRNYNIE 2067
                     68999*************************************************************88999*****************999988 PP

  Guanylate_cyc   96 s.keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182 
                     + +++l++rvGi+tG+vvagviG+kk+ yd+wG+t+n+Asrmest+ ag+iq+s++ty+   + +fe+++r +vevkGkg  ety+l+
     EFC36034.1 2068 HpQNQLNIRVGINTGSVVAGVIGKKKFAYDLWGDTINTASRMESTSMAGRIQISRSTYQRVYDIGFEFEQR-SVEVKGKGVCETYLLK 2154
                     88******************************************************************998.69***********997 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.4   0.1   2.2e-15   3.6e-12       2     103 ..    1822    1934 ..    1821    1935 .. 0.87

  Alignments for each domain:
  == domain 1  score: 46.4 bits;  conditional E-value: 2.2e-15
       PAS_9    2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.......kerevevvlirkngetfwvlltaspv...... 85  
                  dg l+ n++g i+ +N  a +++G s  +vlg+++  lf  d+++ e+l+++l+++++       +    e++++rkn ++f++++t++        
  EFC36034.1 1822 DGALLANESGDIILFNGPAQNMFGKSISDVLGTNFMHLF--DEHSGEKLSNILKTIKSeidenvkHGDVIELECVRKNSTKFPAMVTIFVSrisgss 1916
                  6788999********************************..******************************************99999666436544 PP

       PAS_9   86 kdddgelvg......iivilrDit 103 
                  +       g      + +++rDit
  EFC36034.1 1917 YK------GksnsmvVSCFMRDIT 1934
                  33......222334377******9 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.1   1.7e+03      43      98 ..     971    1026 ..     968    1032 .. 0.69
   2 !   27.9   0.0   1.1e-09   1.9e-06       4      94 ..    1814    1896 ..    1812    1912 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.1
                  TSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC...TTSSEEEEEEEEEEEEE CS
         PAS   43 gkslldliheeddaelaelleqlleqgeesrageisfkl...rdgrpihlevraspvrd 98  
                  ++ l+ +i+ +d   +++++ ++l+++  +++ ++  ++    ++++i++ ++  + ++
  EFC36034.1  971 SSVLVNYIWQDD---HRSQFANYLLAKALKHCHQTLKRVlitEKQKEIEITLNELTKTN 1026
                  556888999998...78888888888888888888777775566666666666555555 PP

  == domain 2  score: 27.9 bits;  conditional E-value: 1.1e-09
                  HHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEECTTSSEEEEEEEEE CS
         PAS    4 raileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfklrdgrpihlevras 94  
                  + +++s+ d+ ++ +e+g+i+++N  a+ ++G s ++vlg ++++l+ e       e+l++ l++ +++ ++++    ++g +i+le+ ++
  EFC36034.1 1814 KKLMSSMVDGALLANESGDIILFNGPAQNMFGKSISDVLGTNFMHLFDEH----SGEKLSNILKTIKSEIDENV----KHGDVIELECVRK 1896
                  67899******************************************887....77888888888777777777....5777777776655 PP

>> DUF2153  Uncharacterized protein conserved in archaea (DUF2153)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.2   0.00015      0.25      69     108 ..     222     261 ..     214     273 .. 0.90
   2 !   10.1   0.7   0.00033      0.53      68     108 ..    1027    1067 ..     983    1074 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00015
     DUF2153  69 dvketlreilekllelDieHtsevrelleklskegklnpl 108
                 +v++ ++e+++kl el i H s  +e+l+++ +e kl ++
  EFC36034.1 222 EVRNAITEVAKKLEELRIVHRSFWKEMLNEMPNETKLLQI 261
                 79999*******************************9776 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00033
     DUF2153   68 ldvketlreilekllelDieHtsevrelleklskegklnpl 108 
                  ++v++t++e+ ++l el i H s  +e+l+++ +e kl ++
  EFC36034.1 1027 MEVRNTITELEITLAELRIVHKSFWKEMLNDIPNETKLSQI 1067
                  57889999999999************************987 PP

>> TAF1D  TATA box-binding protein-associated factor 1D
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   1.9   4.9e-05     0.081     113     170 ..     273     328 ..     241     333 .. 0.83
   2 !    7.5   0.1    0.0018       2.9     113     152 ..    1079    1118 ..    1052    1138 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.9e-05
       TAF1D 113 grkplpwkkiLtyEqavarGffnyieklKyeehLkealkqldageDlekedldvrkyk 170
                 ++    + k  +++++v r + +y+e+ K+++ L ++l  ++ ++ le e+  +rky 
  EFC36034.1 273 EKSFSNLMKSHNHDKTVIRFYAKYVEEFKFDKELSNSL--FEEANQLEDEESRSRKYS 328
                 55556677888999***********************9..68999***********97 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0018
       TAF1D  113 grkplpwkkiLtyEqavarGffnyieklKyeehLkealkq 152 
                   ++ l + k  +++++v r + +y+e+ K+++ L  +l +
  EFC36034.1 1079 DQNFLNLTKAHSHDKTVIRFYASYLEEFKFDKELSTSLFE 1118
                  56778999999************************99854 PP

>> Ni_hydr_CYTB  Prokaryotic cytochrome b561
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.1   8.4e-05      0.14      58     125 ..     642     732 ..     584     765 .. 0.76
   2 !   12.4   0.3   5.2e-05     0.085      49     125 ..    1434    1536 ..    1392    1567 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8.4e-05
                   HHHHHHH........------------STTTSSSSS----------------TT...........THHHHHHHHHHHHHHHHHHHT....H CS
  Ni_hydr_CYTB  58 lfrllwl........kkakkpspriifrqikrdltlllrgrkpeagknnplqkl...........vhlllyvllvvliltGlllsf....a 125
                   ++ +++         +  ++++  +  ++i +d+++++ ++  e  k +++              ++l+++++++++  +Gl++++     
    EFC36034.1 642 VMTMIYVifilisrsEMTWFSKITSLYKKIPKDFVGIIYHKLEEKTKDDAKHLKknpllqpknftLILAILIVVIFMLSSGLIYYEismnI 732
                   4444444444567798888889999999999999999999999988888888778899999***********************9876552 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 5.2e-05
                    HHHHHHHHHHHHHHHH........------------STTTSSSSS----------------TT...........THHHHHHHHHHHHHHHHHHHT CS
  Ni_hydr_CYTB   49 aGlvllalllfrllwl........kkakkpspriifrqikrdltlllrgrkpeagknnplqkl...........vhlllyvllvvliltGlllsf 124 
                    +++++    ++ +++         +  ++++  +  ++i +d+++++ ++  e  k +++              ++l+l++++v++  +Gl++++
    EFC36034.1 1434 LAYIFTSSSVMTMIYVifilisrsEMTWFSKITSLYKKIPKDFVGIIYHKLEEKTKDDAKHLKknpllqpkafsLILALLIVTVFMLSSGLIYYE 1528
                    5666666655555554566677898888889999999999999999999999988888888778899999***********************99 PP

                    .......H CS
  Ni_hydr_CYTB  125 .......a 125 
                           a
    EFC36034.1 1529 ismnistA 1536
                    76653321 PP

>> Transposon_TraM  Conjugative transposon, TraM
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.5    0.0063        10     143     187 ..     161     205 ..     146     207 .. 0.83
   2 ?    8.1   0.0    0.0012       1.9     110     167 ..    1596    1656 ..    1590    1672 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0063
  Transposon_TraM 143 anmgqglgtsinistsagaqiasdalkgviqgasqylskkirkvK 187
                        +++g+ +++n +++ + q+as +l+++++ +s+ ++k i   K
       EFC36034.1 161 MLIISGMLINFNSKEDNKYQFASYLLAKAYKRTSNTIKKLIVLEK 205
                      4578999999999999999*******************9987766 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0012
  Transposon_TraM  110 kiipVeLsvYDt..dGqeGlyvpeslerdavkeiaanmgqglgtsinis.tsagaqiasda 167 
                       ++i+   ++YD+   Gq+G+  p + +++ +  i + + + +++si+ + +s g+ i+ + 
       EFC36034.1 1596 QFIDLTATIYDQviYGQDGITTPLVGKYSKLDKIITGLSTCTNSSIDYNwKSNGNKIIGQS 1656
                       67888899***8889**********************************9****9998876 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00011      0.17       3      55 ..    1813    1866 ..    1812    1879 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
       PAS_8    3 lralfesspdgiavvd.lgdrivdvNqaalellGys.adlkgellgqllpvlrpl 55  
                  l+ l+ s+ dg ++++  gd i+  N  a+ ++G s  d++g  +  l++++ ++
  EFC36034.1 1813 LKKLMSSMVDGALLANeSGD-IILFNGPAQNMFGKSiSDVLGTNFMHLFDEHSGE 1866
                  6789999*********9***.*************776666665555666666655 PP

>> DUF2564  Protein of unknown function (DUF2564)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.2     0.019        31      53      77 ..     566     590 ..     555     592 .. 0.86
   2 ?    5.1   0.2     0.019        31      53      77 ..    1367    1391 ..    1356    1393 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.019
     DUF2564  53 tgvdeeFleeseqlldkaehQLdEa 77 
                  +v++eFl++ eq l+  e+Q +E 
  EFC36034.1 566 SEVSQEFLHHVEQFLNFGEKQYNET 590
                 4799*******************97 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.019
     DUF2564   53 tgvdeeFleeseqlldkaehQLdEa 77  
                   +v++eFl++ eq l+  e+Q +E 
  EFC36034.1 1367 SEVSQEFLHHVEQFLNFGEKQYNET 1391
                  4799*******************97 PP

>> DUF668  Protein of unknown function (DUF668)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.033        55      14      58 ..     645     689 ..     642     704 .. 0.88
   2 ?   -3.1   0.2       7.2   1.2e+04      50      80 ..     994    1022 ..     991    1023 .. 0.82
   3 ?    4.4   0.0     0.033        53      14      58 ..    1446    1490 ..    1442    1505 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.033
      DUF668  14 vivlieklvarsssvpesardeLYqmLpasvrsalrakLrslekk 58 
                 +i +i+ l++rs+++  s+  +LY+ +p+     + +kL++ +k+
  EFC36034.1 645 MIYVIFILISRSEMTWFSKITSLYKKIPKDFVGIIYHKLEEKTKD 689
                 79999*************************999999999998887 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 7.2
      DUF668   50 akLrslekkeavdellaaeikeevekiLewL 80  
                  + L++++++   + +l++e ++e+e +L+ L
  EFC36034.1  994 KALKHCHQT--LKRVLITEKQKEIEITLNEL 1022
                  568888888..8999********99999866 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.033
      DUF668   14 vivlieklvarsssvpesardeLYqmLpasvrsalrakLrslekk 58  
                  +i +i+ l++rs+++  s+  +LY+ +p+     + +kL++ +k+
  EFC36034.1 1446 MIYVIFILISRSEMTWFSKITSLYKKIPKDFVGIIYHKLEEKTKD 1490
                  79999*************************999999999998887 PP

>> E2  Bacteriophage E2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   1.0     0.024        39      11      27 ..     598     614 ..     593     617 .. 0.83
   2 ?   -3.3   0.0       5.6   9.1e+03      11      24 ..     771     784 ..     770     785 .. 0.86
   3 ?    4.2   1.1     0.025        40      12      28 ..    1400    1416 ..    1394    1418 .. 0.83
   4 ?   -3.3   0.0       5.6   9.1e+03      11      24 ..    1572    1585 ..    1571    1586 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.024
          E2  11 GKFiKRRLLiDnFsnFC 27 
                   ++ RR L Dn+  FC
  EFC36034.1 598 YVYLNRRYLADNYLQFC 614
                 56889************ PP

  == domain 2  score: -3.3 bits;  conditional E-value: 5.6
          E2  11 GKFiKRRLLiDnFs 24 
                 GKFi    L+ n s
  EFC36034.1 771 GKFINSPYLVSNNS 784
                 9***9999998876 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.025
          E2   12 KFiKRRLLiDnFsnFCH 28  
                   ++ RR L Dn+  FC 
  EFC36034.1 1400 IYLNRRYLADNYLQFCK 1416
                  5789************5 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 5.6
          E2   11 GKFiKRRLLiDnFs 24  
                  GKFi    L+ n s
  EFC36034.1 1572 GKFINSPYLVSNNS 1585
                  9***9999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1152  (0.0642534); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 1.20u 0.32s 00:00:01.52 Elapsed: 00:00:00.55
# Mc/sec: 11905.52
//
Query:       EFC36035.1  [L=649]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.056   13.3   0.7       0.12   12.2   0.7    1.5  1  DUF2153   Uncharacterized protein conserved in archaea (DUF21


Domain annotation for each model (and alignments):
>> DUF2153  Uncharacterized protein conserved in archaea (DUF2153)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.7   6.5e-06      0.12      68     109 ..     582     623 ..     537     630 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.5e-06
     DUF2153  68 ldvketlreilekllelDieHtsevrelleklskegklnpll 109
                 ++v++t++e+ ++l el i H s  +e+l+++ +e kl ++ 
  EFC36035.1 582 MEVRNTITELEITLAELRIVHKSFWKEMLNDIPNETKLSQIN 623
                 57888999999999************************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (649 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1423  (0.0793686); expected 358.6 (0.02)
Passed bias filter:                      604  (0.0336884); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.85u 0.35s 00:00:01.20 Elapsed: 00:00:00.55
# Mc/sec: 3525.10
//
Query:       EFC36036.1  [L=377]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0017   17.1   6.8     0.0026   16.5   6.8    1.2  1  TFIIF_alpha  Transcription initiation factor IIF, alpha subun
      0.006   14.9   0.2     0.0072   14.7   0.2    1.1  1  CDC45        CDC45-like protein
  ------ inclusion threshold ------
       0.31   11.1   2.0       0.61   10.2   2.0    1.4  1  Podoplanin   Podoplanin
       0.31   10.9   3.2        1.3    8.8   3.2    1.9  1  Coilin_N     Coilin N-terminus
        2.8    8.0  13.4       0.54   10.3   6.6    2.0  2  YL1          YL1 nuclear protein
        5.6    7.6  10.9         57    4.4  10.6    2.3  1  SPT6_acidic  Acidic N-terminal SPT6


Domain annotation for each model (and alignments):
>> TFIIF_alpha  Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   6.8   8.5e-07    0.0026     313     408 ..     144     236 ..     132     255 .. 0.63

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 8.5e-07
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXX CS
  TFIIF_alpha 313 ieqdedeeekeeekkeeegklskkkkkakklkkkkkekdkkdSddeedsddsDideedsvslvkakKkkekkkeekvdsnessagnsrparpspeq 408
                   + de +eekeee  + +g+l+    + kk k +k+     +S+++ +   +D++ ++++   + +K k  ++++kv  ++ss   +++ +   +q
   EFC36036.1 144 ADDDEMSEEKEEEI-NVDGGLEPVTTNRKKRKPRKRAAASASSSSSAETMIEDQEPKSGTKRKTSEKTK--PRKKKVVAASSSGDDTGSIQSYNSQ 236
                  34455555665555.677788887777777777777776677767777777777777776655555544..4566665666666666655444444 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.2   2.4e-06    0.0072     138     233 ..     145     246 ..      54     252 .. 0.66

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2.4e-06
       CDC45 138 eeeeeddddeeeeeeeeedeedeeedeeeskkkrk....sksdeeee......sddddersrkrrrsepsakklrrq.lkkerrkyeavlekyysqgts 225
                 +++e ++++eee + +   e  ++++++++ +kr     s+s    +      +d++ ++  kr+ se ++k ++++   +  +   +   + y++ t 
  EFC36036.1 145 DDDEMSEEKEEEINVDGGLEPVTTNRKKRKPRKRAaasaSSS----SsaetmiEDQEPKSGTKRKTSE-KTKPRKKKvVAASSSGDDTGSIQSYNSQTL 238
                 233333333333334444444444444444455555443222....1234565555555556666666.555555554444444445555566777799 PP

       CDC45 226 ygesvssl 233
                  g+s s l
  EFC36036.1 239 SGNSLSPL 246
                 99999866 PP

>> Podoplanin  Podoplanin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   2.0    0.0002      0.61      28     112 ..     144     225 ..     130     248 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.0002
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----GGG-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Podoplanin  28 peddivtpgvedekvtpGvednvvttgaseepyesglttlvptstesvtdlrledlptaestvkakeesqstttlnvvtshstek 112
                 ++dd +    e+e  + G  + v+t+ ++++p++ + +   + s  s +++ +ed+  + +t ++  e+ +   ++vv+++s   
  EFC36036.1 144 ADDDEMSEEKEEEINVDGGLEPVTTNRKKRKPRKRAAA---SASSSSSAETMIEDQEPKSGTKRKTSEKTKPRKKKVVAASSSGD 225
                 67888899999999999877777777777776665444...46889999999****99999988888888888788777666433 PP

>> Coilin_N  Coilin N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   3.2   0.00045       1.3      62     132 ..     115     196 ..     103     236 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00045
    Coilin_N  62 EsirvlrdndcirV........................................................klegsetkleaqesededsresasksast 104
                   ++v+r+n+ + V                                                        +                            
  EFC36036.1 115 TRLAVVRNNSNLSVvqaiylngedeplwiadddemseekeeeinvdgglepvttnrkkrkprkraaasasS---------------------------- 185
                 56789*****************9877777776666666666666555555444444444444433322211............................ PP

    Coilin_N 105 tkqkkkkKrekkqeeqdeqkasqaakdk 132
                                  +++a++ ++d+
  EFC36036.1 186 -----------------SSSAETMIEDQ 196
                 .................22222222211 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   6.6   0.00018      0.54      56     125 ..     144     216 ..     121     239 .. 0.58
   2 ?    1.9   0.5     0.068     2e+02      27      67 ..     327     373 ..     303     376 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00018
                 xxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxx RF
         YL1  56 deedeesdeeedeeegekele..rqerkkrkkekkkrkaqkkkskkkkkkqkkkkkkkidp...qakeprpkkks 125
                  ++de s+e+e+e + +  le    +rkkr  +++kr+a++++s+++ ++ +++++ k      ++++++p+kk+
  EFC36036.1 144 ADDDEMSEEKEEEINVDGGLEpvTTNRKKR--KPRKRAAASASSSSSAETMIEDQEPKSGTkrkTSEKTKPRKKK 216
                 344444555555555555555445555555..6788887777777777666666655444332111133555555 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.068
                 xxxxxxxxx.xxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxx RF
         YL1  27 lFaEeedDe.efeseeeeeeee.....nsDsdfdsdeedeesdeeed 67 
                 lF+E   D   +  ++++e ++     nsD df  +++d +s++ e+
  EFC36036.1 327 LFEECITDLlAYDPNQQDESSNgnfplNSDFDFLFEQDDSNSNSREQ 373
                 67777777667777777776669999988888855555444444443 PP

>> SPT6_acidic  Acidic N-terminal SPT6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4  10.6     0.019        57      20      68 ..     142     196 ..     136     219 .. 0.47

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.019
  SPT6_acidic  20 FIvdddeeeeeeeesee........eeekkrrkkkkkrre.....eeedaLdedDldLieen 68 
                  +I ddde +ee+ee+ +        ++++k+rk +k+        +           +ie++
   EFC36036.1 142 WIADDDEMSEEKEEEINvdgglepvTTNRKKRKPRKRAAAsasssS-------SAETMIEDQ 196
                  7999996555544433356789765323333333333222333221.......222334433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1154  (0.064365); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 2432.96
//
Query:       EFC36037.1  [L=127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.078   12.7   0.0      0.088   12.6   0.0    1.2  1  DEAD      DEAD/DEAH box helicase


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   4.9e-06     0.088      89     149 ..      22      81 ..       6     109 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 4.9e-06
                 HHHHHHHTTCSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  89 dqlskldngvdivvgtpgrlddllstgklnlsqvrflVlDEadrlldqgfsdfinrilnql 149
                 +  ++  ++v+i+++  +rl+ ++++g +++ +v ++++D      + +  ++ +  ++++
  EFC36037.1  22 ET-KESTKHVNIIISSLSRLLGFIRRGIIDTTDVDLIIVDDFEYSKSLNSLQDFKYFFSRF 81 
                 33.334488*******************************999888876666666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       493  (0.0274974); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.34s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 731.57
//
Query:       EFC36038.1  [L=366]
Description: hypothetical protein NAEGRDRAFT_82314 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.043   13.6   6.6       0.45   10.3   0.3    3.2  3  DUF3841   Domain of unknown function (DUF3841)


Domain annotation for each model (and alignments):
>> DUF3841  Domain of unknown function (DUF3841)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.3   2.5e-05      0.45     107     163 ..      29      85 ..      25      96 .. 0.91
   2 ?    2.7   0.5    0.0054        96     103     133 ..     132     162 ..     116     179 .. 0.80
   3 ?    2.2   0.0    0.0074   1.3e+02      60      89 ..     199     228 ..     187     256 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 2.5e-05
     DUF3841 107 YipedeedekafeeelekygvneaeavtsigkfypelkkkiikSWerlFdakeekee 163
                 ++  d+   k f+ + +k gv++ +++ts g++y   + ++++ +  +F ++++k+e
  EFC36038.1  29 FLAADKVKLKDFYLKNKKAGVKQESVFTSFGQLYGYSNSQVRRAYYSIFGKQKTKNE 85 
                 778899999************99999999********************99998877 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.0054
     DUF3841 103 LnesYipedeedekafeeelekygvneaeav 133
                 L+++ +++d +de  +e++ e+y +++ ++ 
  EFC36038.1 132 LEKEPTYDDDDDECDYEQSDEDYEYSDEDIL 162
                 77777999****************9665554 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.0074
     DUF3841  60 eypiWvwvrekallrksektvileLevpke 89 
                  +p W  ++ +++ + +ek+++++++++ +
  EFC36038.1 199 RFPTWTDFKFSHVEMSKEKMIVIHVKINAK 228
                 69******99***************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1613  (0.089966); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 2088.39
//
Query:       EFC36039.1  [L=164]
Description: hypothetical protein NAEGRDRAFT_76296 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0063   16.4   0.1       0.01   15.7   0.1    1.3  1  F-box-like      F-box-like
  ------ inclusion threshold ------
       0.17   12.2   3.5       0.49   10.7   2.3    2.2  2  WXG100          Proteins of 100 residues with WXG
       0.21   11.5   0.4       0.21   11.5   0.4    1.7  2  F-box           F-box domain
       0.33   11.0   9.1       0.63   10.1   3.0    2.3  2  DUF1664         Protein of unknown function (DUF1664)
       0.36   11.2   0.1       0.36   11.2   0.1    3.1  3  PRANC           PRANC domain
        1.1    9.9  18.1       0.19   12.4  11.6    2.3  3  HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interac
        1.3    9.3   4.4        4.3    7.6   0.2    2.6  2  DUF948          Bacterial protein of unknown function (DUF948
        2.3    8.5  16.0        2.2    8.6   2.9    2.5  2  Seryl_tRNA_N    Seryl-tRNA synthetase N-terminal domain
        3.1    8.4   6.1         17    6.0   6.1    2.2  1  YtxH            YtxH-like protein
        3.8    7.4   8.8       0.21   11.4   2.3    2.3  2  Tho1_MOS11_C    Tho1/MOS11 C-terminal domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.1   5.6e-06      0.01       3      45 ..       6      48 ..       4      50 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 5.6e-06
  F-box-like  3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrl 45
                +LP E+ ++IFs L+ + L ++    ++ ++       +Wr+l
  EFC36039.1  6 DLPSELQIEIFSILSVKHLRNILSINKSIHEQLIQSETFWRTL 48
                8********************9999999998665555999987 PP

>> WXG100  Proteins of 100 residues with WXG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       3.1   5.5e+03      74      79 ..      63      68 ..      45      80 .. 0.50
   2 ?   10.7   2.3   0.00027      0.49      14      76 ..      92     160 ..      88     161 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.1
                HHHHHH CS
      WXG100 74 lkqaan 79
                ++qa++
  EFC36039.1 63 VEQASQ 68
                222222 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00027
                 HHHHHHHHHHHHHHHHHHHHHHHCGC......GCTHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      WXG100  14 arfqkqaeeledelqrlkaevdalqs......gWsGaaadafqaefeewkqaaqklvdaLeeisealkq 76 
                 ++fq+ + ele +l++l+  + ++++         G+ +d+f++++e +kq+ + ++++ eei+e+lk+
  EFC36039.1  92 KQFQQMSMELEYMLRELEMVQREMNArnestlLLGGNISDQFKNQIESLKQKGESVKKETEEIAEKLKK 160
                 78999999999999999999999955456555578********************************97 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.4   0.00012      0.21       2      26 ..       3      27 ..       2      36 .. 0.84
   2 ?   -3.3   0.1       5.2   9.3e+03      33      38 ..      45      50 ..      43      52 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00012
                HHHHS-HHHHHHHHHTS-HHHHHHH CS
       F-box  2 tlsrLPsevlrhILerLplsdllal 26
                ++ +LPse+  +I++ L+ ++l ++
  EFC36039.1  3 NFVDLPSELQIEIFSILSVKHLRNI 27
                5779***************998665 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 5.2
                HHHHHT CS
       F-box 33 wrilid 38
                wr li+
  EFC36039.1 45 WRTLIK 50
                999998 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   3.0   0.00035      0.63      46     110 ..      52     115 ..      45     123 .. 0.84
   2 ?    4.3   0.4     0.021        38      82     109 ..     130     157 ..     120     162 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00035
     DUF1664  46 vskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeav 110
                  sk + +    ++++ ++L  +i++v k+l e++ei+k  +++ ++++ +l+ + +++e v++ +
  EFC36039.1  52 YSKVIGESAYGVEQASQELF-EIENVKKQLIEMIEIKKRKTKQFQQMSMELEYMLRELEMVQREM 115
                 56666666677788888886.6************************************9999765 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.021
     DUF1664  82 skeikeevtevredlseigedvesvkea 109
                 s + k+++++++++ ++++++ e++ e 
  EFC36039.1 130 SDQFKNQIESLKQKGESVKKETEEIAEK 157
                 4555555555555555555555555443 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1    0.0002      0.36      72      96 ..       4      28 ..       1      29 [. 0.90
   2 ?    0.8   0.9      0.35   6.3e+02      17      52 ..      33      67 ..      27     108 .. 0.56
   3 ?    0.8   0.2      0.36   6.4e+02      41      68 ..     133     160 ..     128     164 .] 0.62

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.0002
       PRANC 72 WnlLPiEIkykIleyLndkdLknll 96
                   LP E++++I++ L+ k+L+n+l
  EFC36039.1  4 FVDLPSELQIEIFSILSVKHLRNIL 28
                568********************97 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.35
       PRANC 17 nllvrlinkkklkklkslkiYgklikkiiksakkry 52
                +++ +li+ + + ++  +k+Y k+i ++ + +++ +
  EFC36039.1 33 SIHEQLIQSETFWRT-LIKNYSKVIGESAYGVEQAS 67
                455555655555544.55666666666555444433 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.36
       PRANC  41 ikkiiksakkrykliekaievlnnicsk 68 
                  k+ i+s+k++ + ++k  e + ++++k
  EFC36039.1 133 FKNQIESLKQKGESVKKETEEIAEKLKK 160
                 4566666666666666666666666554 PP

>> HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interacting protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       7.6   1.4e+04      47      52 ..      34      39 ..      21      51 .. 0.52
   2 ?   12.4  11.6    0.0001      0.19      17      95 ..      65     143 ..      58     147 .. 0.84
   3 ?    5.5   1.2     0.015        27      31      59 ..     132     160 ..     127     163 .. 0.60

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 7.6
  HIP1_clath_bdg 47 leeqke 52
                    ++eq  
      EFC36039.1 34 IHEQLI 39
                    233333 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 0.0001
  HIP1_clath_bdg  17 varqaqeeverekkeleeelerlkeeaerkleeqkeelekLkreleakraela.rlkssLesseqsgeqlssqlaaLqaE 95 
                     +a q+  e+e++kk+l e   ++k+ ++++ ++ ++ele + rele+ + e++ r +s+L    + ++q ++q+++L++ 
      EFC36039.1  65 QASQELFEIENVKKQLIEM-IEIKKRKTKQFQQMSMELEYMLRELEMVQREMNaRNESTLLLGGNISDQFKNQIESLKQK 143
                     55566679********865.56899999*******************9999962567899999*************9875 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.015
  HIP1_clath_bdg  31 eleeelerlkeeaerkleeqkeelekLkr 59 
                     + ++++e+lk++ e+  +e +e  ekLk+
      EFC36039.1 132 QFKNQIESLKQKGESVKKETEEIAEKLKK 160
                     55566666666666666666666666665 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.7     0.065   1.2e+02      36      65 ..      88     117 ..      15     125 .. 0.75
   2 ?    7.6   0.2    0.0024       4.3      26      59 ..     128     161 ..     121     164 .] 0.87

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.065
      DUF948  36 eelekqvdpilkevedllakvnelledvne 65 
                 +  +kq ++++ e+e +l++ + ++ ++n 
  EFC36039.1  88 KRKTKQFQQMSMELEYMLRELEMVQREMNA 117
                 333477777777777777777766666555 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0024
      DUF948  26 ktldeaaatieelekqvdpilkevedllakvnel 59 
                 ++ d+++++ie+l+++ +++ ke+e++ +k +++
  EFC36039.1 128 NISDQFKNQIESLKQKGESVKKETEEIAEKLKKT 161
                 677999***********************99985 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   2.9    0.0012       2.2      31     104 ..      27     101 ..      19     104 .. 0.80
   2 ?    5.1   5.7     0.015        26      52      92 ..     118     160 ..     100     163 .. 0.60

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0012
                   HHHHHHHHHHHHHHHHHH.HHHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCTS CS
  Seryl_tRNA_N  31 lleldekrrelqveleel.qaerNelskeIgkakkkkedaeeliaevkelkeelkaleaelkeleaeleklllai 104
                   +l++++   e  ++ e + ++  ++ sk Ig+     e+a++ + e++++k++l ++ +  k  +++++++ +++
    EFC36039.1  27 ILSINKSIHEQLIQSETFwRTLIKNYSKVIGESAYGVEQASQELFEIENVKKQLIEMIEIKKRKTKQFQQMSMEL 101
                   5555555555555555433888999*******99877*******************************9998765 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.015
                   HHHHHHHCCCCCCTT..S-TCCCCCCCHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  52 rNelskeIgkakkkk..edaeeliaevkelkeelkaleaelke 92 
                   rNe +   g  + ++  +++e+l+++++++k+e++++ ++lk+
    EFC36039.1 118 RNESTLLLGGNISDQfkNQIESLKQKGESVKKETEEIAEKLKK 160
                   4444444555555445566777777777777777777777765 PP

>> YtxH  YtxH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   6.1    0.0097        17      36      67 ..     128     162 ..      46     164 .] 0.87

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0097
        YtxH  36 dlkekakelleeakeka...kekaedlkekvkeka 67 
                 ++++++k+ +e++k+k+   k+++e+++ek+k+++
  EFC36039.1 128 NISDQFKNQIESLKQKGesvKKETEEIAEKLKKTI 162
                 56677777777777777777888888888888775 PP

>> Tho1_MOS11_C  Tho1/MOS11 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   2.3   0.00012      0.21       2      39 ..      74     111 ..      73     113 .. 0.86
   2 ?   -1.4   0.5       1.2   2.1e+03      29      37 ..     137     145 ..     132     162 .. 0.50

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00012
  Tho1_MOS11_C   2 eeikqqaielLekklkRakKFgqeeeaidelekqleRi 39 
                   e  k+q+ie++e k++  k F+q + +++ + ++le +
    EFC36039.1  74 ENVKKQLIEMIEIKKRKTKQFQQMSMELEYMLRELEMV 111
                   789********************998887777777755 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.2
  Tho1_MOS11_C  29 idelekqle 37 
                   i++l+++ e
    EFC36039.1 137 IESLKQKGE 145
                   444444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2798  (0.15606); expected 358.6 (0.02)
Passed bias filter:                      709  (0.0395449); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.63u 0.37s 00:00:01.00 Elapsed: 00:00:00.56
# Mc/sec: 880.68
//
Query:       EFC36040.1  [L=209]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.1e-05   22.3   0.8       0.14   12.1   0.0    2.3  2  TPR_1     Tetratricopeptide repeat
    0.00024   21.0   1.5      0.034   14.2   0.1    2.4  2  TPR_2     Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.18   12.0   0.5        3.3    7.9   0.2    2.1  2  TPR_9     Tetratricopeptide repeat
       0.99    9.6   3.3        2.1    8.6   0.2    2.2  2  MRPL52    Mitoribosomal protein mL52


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   3.1e-05      0.14       1      33 [.      87     119 ..      87     120 .. 0.92
   2 !    8.7   0.1   0.00034       1.5       8      31 ..     131     154 ..     131     156 .. 0.95

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.1e-05
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   1 akalynlGnayfklgkydeAleyyekALelnPn 33 
                 a+ + +++++ +   ky+ Ale+ + AL l+++
  EFC36040.1  87 ARLHVQRAVVRLAAMKYEGALEDIKLALHLDES 119
                 6788999***********************986 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00034
                 HHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   8 GnayfklgkydeAleyyekALeln 31 
                 G+a+++ g+y e   ++++ +el 
  EFC36040.1 131 GVALYHCGDYLESAHAFKRGIELK 154
                 89********************96 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.1    0.0045        20       2      32 ..      88     118 ..      87     120 .. 0.85
   2 !   14.2   0.1   7.7e-06     0.034       3      31 ..     126     154 ..     125     156 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0045
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldP 32 
                 +++ +++ + +++ +ye Ale+ + Al ld+
  EFC36040.1  88 RLHVQRAVVRLAAMKYEGALEDIKLALHLDE 118
                 677788888888889************9996 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 7.7e-06
       TPR_2   3 alynlGlayyklgdyeeAleafekAleld 31 
                 +++  G a+y+ gdy e ++af++ +el 
  EFC36040.1 126 WNFVYGVALYHCGDYLESAHAFKRGIELK 154
                 56889*********************995 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.2   0.00075       3.3      25      61 ..      83     119 ..      81     125 .. 0.90
   2 ?    2.1   0.0     0.048   2.2e+02      36      59 ..     131     154 ..     127     161 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00075
       TPR_9  25 aPddpeerrdRGlllaqlGclsaAladLeaylalapd 61 
                 +P+ ++++  R++++     +++Al+d   +l+l+++
  EFC36040.1  83 DPQVARLHVQRAVVRLAAMKYEGALEDIKLALHLDES 119
                 69999************************99999874 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.048
       TPR_9  36 GlllaqlGclsaAladLeaylala 59 
                 G++l++ G++ + + ++ + ++l 
  EFC36040.1 131 GVALYHCGDYLESAHAFKRGIELK 154
                 99*************999877765 PP

>> MRPL52  Mitoribosomal protein mL52
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.3     0.067     3e+02      44      80 ..      39      75 ..      24      87 .. 0.58
   2 ?    8.6   0.2   0.00047       2.1      44      83 ..     164     203 ..     152     208 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.067
      MRPL52 44 kkkqeelakkivkllsEideaeerykkkqeeeeeeeq 80
                 k++e++++ + +++++++e     k+ ++e + e +
  EFC36040.1 39 RKNNEKIESGVSHISKDLKEKILFRKQLIAESKLEGK 75
                4555666666666666666666666666655555555 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00047
      MRPL52  44 kkkqeelakkivkllsEideaeerykkkqeeeeeeeqkii 83 
                  kk  el+k i  +  E+++  e++k++  e  e++++  
  EFC36040.1 164 DKKSVELEKNILDINFEMKHSHEKVKEQFTEFSENTKTYF 203
                 57889***********************999999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1154  (0.064365); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.35s 00:00:00.93 Elapsed: 00:00:00.55
# Mc/sec: 1151.06
//
Query:       EFC36041.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.7e-12   46.8  38.9    1.4e-05   25.3   5.0    3.7  3  EGF_2         EGF-like domain
     0.0066   16.7  28.9      0.015   15.6   3.9    3.8  3  EGF           EGF-like domain
  ------ inclusion threshold ------
      0.037   14.1   1.0      0.037   14.1   1.0    3.6  3  EGF_Tenascin  Tenascin EGF domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.3   5.0   2.4e-09   1.4e-05       7      32 .]     348     372 ..     344     372 .. 0.92
   2 !   15.4  11.8   2.9e-06     0.018       5      32 .]     385     411 ..     380     411 .. 0.85
   3 !   17.5   6.3   6.6e-07     0.004       5      32 .]     424     452 ..     421     452 .. 0.81

  Alignments for each domain:
  == domain 1  score: 25.3 bits;  conditional E-value: 2.4e-09
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +C+g+GtCv+ +  C+C+ +y+G+ C
  EFC36041.1 348 ACHGNGTCVDVN-TCMCNENYYGPEC 372
                 6*******9777.9************ PP

  == domain 2  score: 15.4 bits;  conditional E-value: 2.9e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+g+G+C++ +  C+C+s+y G +C
  EFC36041.1 385 STACNGNGICERYN-YCKCNSNYGGENC 411
                 789*******9555.4***********9 PP

  == domain 3  score: 17.5 bits;  conditional E-value: 6.6e-07
       EGF_2   5 deiCgghGtCvnqcGqCdC.dsgyq.GktC 32 
                 ++ C+g+G+C++++  C+C +++++ G +C
  EFC36041.1 424 ETVCSGNGSCIALN-TCQCfNTSRYvGEKC 452
                 788********888.9***95555559999 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   3.9   2.5e-06     0.015       3      31 ..     343     370 ..     342     371 .. 0.90
   2 !    5.7   7.7    0.0032        19       5      32 .]     386     410 ..     383     410 .. 0.86
   3 !    6.2   1.8    0.0021        13       5      24 ..     425     441 ..     420     450 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.5e-06
                 STT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp...CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++p   C+++GtCvd+     tC C e y G+
  EFC36041.1 343 KYPflaCHGNGTCVDVN----TCMCNENYYGP 370
                 578888***********....********996 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0032
                 T.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 + C+++G+C ++     +C+C + y G++
  EFC36041.1 386 TaCNGNGICERYN----YCKCNSNYGGEN 410
                 34*******8888....9*********86 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0021
                 T.STTT-EEEEETTTEEEEEE CS
         EGF   5 p.CsngGtCvdtgrggytCiC 24 
                 + Cs++G C+ +     tC+C
  EFC36041.1 425 TvCSGNGSCIALN----TCQC 441
                 46*******9999....9999 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   1.0   6.2e-06     0.037       4      28 ..     347     372 ..     344     373 .. 0.87
   2 ?    5.4   3.8    0.0034        20       6      28 ..     388     411 ..     386     412 .. 0.81
   3 ?    3.4   3.0     0.014        81       6      28 ..     427     452 ..     425     453 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 6.2e-06
  EGF_Tenascin   4 LGCssRGvCvDG.qCiCDsEYsGDDC 28 
                   L C   G CvD   C+C+ +Y G +C
    EFC36041.1 347 LACHGNGTCVDVnTCMCNENYYGPEC 372
                   89*********626*********999 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0034
  EGF_Tenascin   6 CssRGvCvD.GqCiCDsEYsGDDC 28 
                   C   G+C     C C+s+Y G++C
    EFC36041.1 388 CNGNGICERyNYCKCNSNYGGENC 411
                   777888865257***********9 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.014
  EGF_Tenascin   6 CssRGvCvD...GqCiCDsEYsGDDC 28 
                   Cs  G C+     qC   s Y G+ C
    EFC36041.1 427 CSGNGSCIAlntCQCFNTSRYVGEKC 452
                   9999***9543489999*******99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 3115.88
//
Query:       EFC36042.1  [L=178]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.1e-63  213.8   0.1    1.2e-63  213.7   0.1    1.0  1  Arf        ADP-ribosylation factor family
      1e-13   51.2   0.0    1.1e-13   51.1   0.0    1.1  1  Ras        Ras family
    9.7e-12   44.7   1.1    1.7e-08   34.1   0.1    2.3  2  G-alpha    G-protein alpha subunit
    1.2e-11   44.9   0.0    1.6e-11   44.4   0.0    1.2  1  Roc        Ras of Complex, Roc, domain of DAPkinase
    7.2e-10   38.6   0.0    8.8e-10   38.3   0.0    1.1  1  SRPRB      Signal recognition particle receptor beta subunit
    4.8e-07   29.4   0.0    6.1e-07   29.0   0.0    1.1  1  Gtr1_RagA  Gtr1/RagA G protein conserved region
    0.00024   21.2   0.0    0.00034   20.7   0.0    1.2  1  MMR_HSR1   50S ribosome-binding GTPase


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  213.7   0.1   4.8e-67   1.2e-63       9     174 ..      13     177 ..       5     178 .] 0.96

  Alignments for each domain:
  == domain 1  score: 213.7 bits;  conditional E-value: 4.8e-67
                 TT..TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHH CS
         Arf   9 klk.kkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLka 106
                  l  +ke++il+lGLD+aGKt  l+k++l+e v+t+PTigfn e +++k ++f+v+D+GGq+ +R lW++Y++ tdavif+vDs+dreR+ee +e L++
  EFC36042.1  13 SLFeQKEAKILFLGLDAAGKTSTLYKIQLDENVSTIPTIGFNAEVIQYKRVQFRVFDIGGQDMIRTLWRHYYNGTDAVIFIVDSNDRERFEEVSETLHK 111
                 43338********************************************************************************************** PP

                 HCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 107 lleeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlses 174
                 ++e+  l++++llv+aNKqDlp a++ ++++++l+l+++k  ++++iq csa++g+gl egl+wls++
  EFC36042.1 112 VMEDPSLSNAKLLVWANKQDLPRAANVTDIAKNLQLNSIK--QDWYIQPCSALNGSGLFEGLDWLSNK 177
                 ****************************************..9**********************997 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.1   0.0   4.4e-17   1.1e-13       1     149 [.      21     167 ..      21     178 .] 0.81

  Alignments for each domain:
  == domain 1  score: 51.1 bits;  conditional E-value: 4.4e-17
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++++G  a GKts l++   d+   + ++Tig++  +    ++ k+v+++++D  Gq+  ++l + yy+++++++ + d ++re fe+v++ ++++ +
  EFC36042.1  21 KILFLGLDAAGKTSTLYKIQLDENV-STIPTIGFNAEV----IQYKRVQFRVFDIGGQDMIRTLWRHYYNGTDAVIFIVDSNDRERFEEVSETLHKVME 114
                 899**************98888855.679***887654....66799********************************************99999998 PP

                 HST.TTSEEEEEEETTTGGGG-SS-H.HHHHHHHHHHTSEEEE.EBTTTTCTH CS
         Ras 100 vae.envpivLvGnKvDleekravst.eegeelakelglkfle.tSAktnenv 149
                   + +n ++++ +nK Dl +  +v+  ++  +l + ++  +++ +SA +  ++
  EFC36042.1 115 DPSlSNAKLLVWANKQDLPRAANVTDiAKNLQLNSIKQDWYIQpCSALNGSGL 167
                 8888999***********99888875133344444444444433777776665 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.6   0.1   0.00018      0.46      21      45 ..      17      41 ..       6      47 .. 0.87
   2 !   34.1   0.1   6.5e-12   1.7e-08     186     281 ..      48     132 ..      42     135 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00018
                ..EEEEEEEESTTSSHHHHHHHHHH CS
     G-alpha 21 krevkllllGqseSGKsTilkqlkl 45
                ++e k+l+lG +  GK+++l +++l
  EFC36042.1 17 QKEAKILFLGLDAAGKTSTLYKIQL 41
                4689*****************9995 PP

  == domain 2  score: 34.1 bits;  conditional E-value: 6.5e-12
                 ----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHH CS
     G-alpha 186 lktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDi 281
                 ++t+G++   ++++  ++fr++d+gGq   r  W ++++++da+iF+v           ++   r+ee  +  +++++ + l n+++++  nK D+
  EFC36042.1  48 IPTIGFNAEVIQYK-RVQFRVFDIGGQDMIRTLWRHYYNGTDAVIFIVD----------SNDRERFEEVSETLHKVMEDPSLSNAKLLVWANKQDL 132
                 789**********9.********************************97..........4455799999999999999999999999999999986 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.4   0.0   6.4e-15   1.6e-11       1     119 [.      21     131 ..      21     132 .. 0.76

  Alignments for each domain:
  == domain 1  score: 44.4 bits;  conditional E-value: 6.4e-15
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHH...HCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrss...enlk 96 
                 K++++G  ++GKts l +++ d+   ++ +tig +    +             k+v+++++D++Gq+ +r+l ++y+++ +++i+++ds++    e+++
  EFC36042.1  21 KILFLGLDAAGKTSTLYKIQLDEN-VSTIPTIGFNAEVIQ------------YKRVQFRVFDIGGQDMIRTLWRHYYNGTDAVIFIVDSNDRerfEEVS 106
                 99***************9987665.577899999874322............35799******************************966550114555 PP

                 HHHHHHHHH..CSSS-EEEEEE-TT CS
         Roc  97 eWlkelkkv..agkspvilvgnkiD 119
                 e l+++ +    +++++++ +nk D
  EFC36042.1 107 ETLHKVMEDpsLSNAKLLVWANKQD 131
                 5554444432234667888899998 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3   0.0   3.5e-13   8.8e-10       3     137 ..      19     145 ..      17     153 .. 0.87

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 3.5e-13
                 --EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHHH CS
       SRPRB   3 kpavllvGlsdsGKTslftrLttdsvkktvtSq.essaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAElly 100
                 + ++l++Gl  +GKTs + ++  d+  +t   +  +  + ++   k  ++++ D+ G++ +r+    +  + +   +++f+vDS  d  + +ev E l 
  EFC36042.1  19 EAKILFLGLDAAGKTSTLYKIQLDENVSTIPTIgFNAEVIQY---KRVQFRVFDIGGQDMIRTLWR-H--YYNGTDAVIFIVDSN-DRERFEEVSETLH 110
                 6789**************************999778888888...99**************98554.4..578899*******97.78889******** PP

                 HHHHHHHHHTT---EEEEEE-TTSTT---HHHHHHHH CS
       SRPRB 101 eilliteklkdavdiliACnKqelflakspklikdaL 137
                 +++ +  +   + ++l+  nKq+l  a + + i ++L
  EFC36042.1 111 KVMEDPSL--SNAKLLVWANKQDLPRAANVTDIAKNL 145
                 ***99984..45689*********9999988888776 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.0   0.0   2.4e-10   6.1e-07       1     136 [.      21     145 ..      21     158 .. 0.81

  Alignments for each domain:
  == domain 1  score: 29.0 bits;  conditional E-value: 2.4e-10
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletl 98 
                 k+L++G   +GKts    ++ +++  + ++   ti  + + +  ++ +++ ++D+gGq+ + +        + ++  +++i+++D+++re +ee  etl
  EFC36042.1  21 KILFLGLDAAGKTST---LY-KIQLDENVSTIPTIGFNAEVI-QYKRVQFRVFDIGGQDMIRTL-----WRHYYNGTDAVIFIVDSNDRErFEEVSETL 109
                 89***********95...44.556666677779999999988.6899***********987665.....4789999***********997799999999 PP

   Gtr1_RagA  99 keilealrqyspeakvfvlihKmDliqedereeifeer 136
                 ++++e  +    +ak+ v  +K Dl +  + ++i ++ 
  EFC36042.1 110 HKVMEDPS--LSNAKLLVWANKQDLPRAANVTDIAKNL 145
                 99999754..4578889999999988777766666655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0   1.3e-07   0.00034       1     114 []      21     129 ..      21     129 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 1.3e-07
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT.TTCSHHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas.eeklkpldeel 97 
                 +++++G   +GK++ + ++      vs +p  T+  n + +++k+ ++++ D+ G  +      +++  ++   + +d+++++vd++ +e ++++ e+l
  EFC36042.1  21 KILFLGLDAAGKTSTLYKIQL-DENVSTIP--TIGFNAEVIQYKRVQFRVFDIGG-QD------MIRTLWRHYYNgTDAVIFIVDSNdRERFEEVSETL 109
                 58899*******999999944.34555555..444444444444678********.44......4555555444579********77756799999999 PP

                 HHHHHH...TTSEEEEEEES CS
    MMR_HSR1  98 eellee...akkplilvlnk 114
                 ++++e+   ++ +l++ +nk
  EFC36042.1 110 HKVMEDpslSNAKLLVWANK 129
                 99987677766667776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       515  (0.0287244); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1131.79
//
Query:       EFC36043.1  [L=110]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.019   14.0   0.0      0.019   14.0   0.0    1.1  1  TED_complement  A-macroglobulin TED domain


Domain annotation for each model (and alignments):
>> TED_complement  A-macroglobulin TED domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   1.1e-06     0.019      66     106 ..      20      61 ..       1      82 [. 0.81

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.1e-06
                     HHHHHHHHTCBETTSEBBSSS...SS-BEHHHHHHHHHHHHH CS
  TED_complement  66 ekgyqrqlsykkadgsysafgkd.ssegstWLtAfvlkvlaq 106
                      +gy+   ++++adg++++  +  + +gs+W t f +++l+ 
      EFC36043.1  20 PAGYVALEKFRNADGAFGVRVNIyNANGSVWKTYFQTQMLNS 61 
                     579****************994369***********999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (110 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       387  (0.0215851); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.32u 0.23s 00:00:00.55 Elapsed: 00:00:00.37
# Mc/sec: 898.44
//
Query:       EFC36044.1  [L=620]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.7e-25   87.3   0.0    1.9e-24   85.9   0.0    1.7  2  HSP70     Hsp70 protein
  ------ inclusion threshold ------
      0.053   13.8   0.3        5.8    7.2   0.0    2.8  3  RskA      Anti-sigma-K factor rskA
      0.068   13.2   0.3       0.17   11.9   0.3    1.7  1  DUF1143   Protein of unknown function (DUF1143)


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.9   0.0   3.1e-28   1.9e-24     153     294 ..       2     139 ..       1     143 [. 0.95
   2 ?   -3.8   0.1      0.44   2.7e+03     508     525 ..     391     408 ..     365     429 .. 0.40

  Alignments for each domain:
  == domain 1  score: 85.9 bits;  conditional E-value: 3.1e-28
                 HHHHHHTTXEEEEEEEHHHHHHHHHHTCCSSSCEEEEEEEEXSSXEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHH CS
       HSP70 153 kdAgkiAGLnvlRivNepTAaalaYGldkkdkernvlvyDlGggtfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkk 251
                 k Ag++AGL++ R + ++ A    Y l k++ er v ++DlG +   +Si+ +e+ +fe +   g +++GG   De lv++++e+f k+ +  l++++ 
  EFC36044.1   2 KKAGEYAGLKIARFIHDTSASCFQY-LWKEHGERRVFLFDLGRSGCSASIMIVESDIFETRTSEGFSNVGGSLLDESLVNYCCEQFYKSFKKHLQENPI 99 
                 89***********************.778888******************************************************************* PP

                 HHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTEEEEEEEE CS
       HSP70 252 alqrlkeaaekaKkeLSsskqteinleietvdedgkdlsekls 294
                  ++rl+ a+e+aKk LS+  + e+++++e++++ g++++++++
  EFC36044.1 100 SMRRLNLACEEAKKRLSN--ELETKISLESLMD-GNEFEITIT 139
                 ******************..7777888899999.999999887 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 0.44
                 HHHHHHHHHCHHHHHHHH CS
       HSP70 508 ekmvkdaeesaeedkkkk 525
                  ++ +   e  + d +++
  EFC36044.1 391 RQLHTTCTEKLDYDVEHH 408
                 222222222222222222 PP

>> RskA  Anti-sigma-K factor rskA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.2      0.02   1.2e+02      30      71 ..     144     220 ..     125     263 .. 0.56
   2 ?   -0.9   0.0      0.28   1.7e+03     108     134 ..     329     356 ..     327     357 .. 0.89
   3 ?    7.2   0.0   0.00098       5.8      27      77 ..     553     602 ..     530     616 .. 0.59

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.02
                 .......................XXXXXXXXXXXXXX.....................................XXXXX CS
        RskA  30 pppaaapaararr..........laaaaAaalllvlg...........................qlavasaaldplrqs 71 
                 p+p++  ++++++          + +++ aal +v+                             +++ +a+ ++ +q+
  EFC36044.1 144 PQPKR--TRKKKAdikksmvnanASTTFKAALNVVVQhasassnvahkqtsasttttgkatsknSNRRKRAKKQAPPQQ 220
                 11111..111112345566777777777777777777555556666655555555555544444333333333333333 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.28
                 XXXXXXXXXXXXXXXXX.XXX..XXXXX CS
        RskA 108 sglpalpagkvyqlWli.paggkpvslG 134
                 + lp+l++ k++ +W   + +++ ++lG
  EFC36044.1 329 YKLPNLKKRKYRHVWRFnNVKSGKRPLG 356
                 689999***********99999999998 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.00098
                 ....................XXXXXXXXXXXXXX..........XXXXXXXXXXX CS
        RskA  27 aaapppaaapaararr....laaaaAaalllvlgqlavasaaldplrqsaaqaea 77 
                   + + +        +    +++a A++ ++ lg   va+++++p +q+++q ++
  EFC36044.1 553 EVPVTSTTTN-----QgngsFWGALAVVGAVSLGAMYVATNNNNPPNQQQQQIQQ 602
                 2322222222.....1345699999999999999666666666666666655444 PP

>> DUF1143  Protein of unknown function (DUF1143)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.3   2.9e-05      0.17      78     138 ..     172     232 ..     148     241 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.9e-05
     DUF1143  78 dlrkivkakplpsqfghafettydtdyskkkpkstrrvkrephwfpghqpeldpprykcta 138
                  l+ +v+     s+ +h   ++  t   k + k ++r kr  +  p +qpe  pp +   +
  EFC36044.1 172 ALNVVVQHASASSNVAHKQTSASTTTTGKATSKNSNRRKRAKKQAPPQQPESTPPSVSNNN 232
                 56779999999********************************************987654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (620 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1887  (0.105248); expected 358.6 (0.02)
Passed bias filter:                      655  (0.036533); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.78u 0.34s 00:00:01.12 Elapsed: 00:00:00.54
# Mc/sec: 3441.54
//
Query:       EFC36045.1  [L=480]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-44  148.6  22.6    1.8e-13   50.0   0.0    7.7  7  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.1   5.6e-07      0.01       4      36 ..     174     206 ..     172     224 .. 0.84
   2 !   15.7   0.2   4.9e-07    0.0088       1      32 [.     253     284 ..     253     290 .. 0.90
   3 !   12.0   0.3   7.5e-06      0.13      16      38 ..     291     313 ..     286     316 .. 0.86
   4 !   16.0   0.2     4e-07    0.0071      17      49 .]     318     350 ..     317     350 .. 0.96
   5 !   44.7   0.6   4.5e-16     8e-12       1      49 []     352     401 ..     352     401 .. 0.94
   6 !    9.2   0.1   5.3e-05      0.95      19      45 ..     396     422 ..     391     425 .. 0.88
   7 !   50.0   0.0     1e-17   1.8e-13       1      49 []     427     475 ..     427     475 .. 0.98

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 5.6e-07
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 +++ ++ +ngs+++yl ++  nD+ei+l +++ 
  EFC36045.1 174 VAKTLIARNGSSIYYLEKSCFNDREILLSCLRV 206
                 57889*************************994 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 4.9e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 +r ++l+ v  +  +++ lse+L nDke+v++
  EFC36045.1 253 NRSLILKMVPEFEVSIYELSEDLWNDKEVVMQ 284
                 67889999999999*****************9 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 7.5e-06
     DUF4116  16 lkylseeLknDkeivlkAvkqng 38 
                 +k+l++ ++nDke++l+ +k  +
  EFC36045.1 291 YKKLPKHIRNDKEVLLAYIKYKP 313
                 788**************999876 PP

  == domain 4  score: 16.0 bits;  conditional E-value: 4e-07
     DUF4116  17 kylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 k+l++eL +D ++++k ++ +++a++++ +eL+
  EFC36045.1 318 KFLNPELVKDLDFLKKVLNYSPNAYKFLTPELK 350
                 799****************************97 PP

  == domain 5  score: 44.7 bits;  conditional E-value: 4.5e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsyaseeLr 49 
                 Dr ++ e+v++n++ +k+l+++++nD+e+++ +vk++g + l+ ++e+Lr
  EFC36045.1 352 DRNLIFEIVENNPCLFKFLDSSFRNDRELIMMIVKKYGtDHLDVIPESLR 401
                 9*************************************446999999998 PP

  == domain 6  score: 9.2 bits;  conditional E-value: 5.3e-05
     DUF4116  19 lseeLknDkeivlkAvkqngtalsyas 45 
                 ++e+L+ Dke++   v++n ++++ ++
  EFC36045.1 396 IPESLRADKELIWSSVEKNADFFNKYP 422
                 8******************99998766 PP

  == domain 7  score: 50.0 bits;  conditional E-value: 1e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+ l+avk++++ l+y+++ L+ D+e+++ A+k++g al++as+ L+
  EFC36045.1 427 DRELLLHAVKHYPYTLQYADPPLCDDFEVIMTACKNSGMALKFASPRLK 475
                 9*********************************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (480 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       568  (0.0316805); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.25s 00:00:00.72 Elapsed: 00:00:00.41
# Mc/sec: 3491.67
//
Query:       EFC36046.1  [L=263]
Description: hypothetical protein NAEGRDRAFT_82313 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.4e-40  137.7   0.2    5.3e-40  137.4   0.2    1.1  1  DNA_alkylation  DNA alkylation repair enzyme
  ------ inclusion threshold ------
      0.081   12.3   0.1       0.13   11.7   0.1    1.2  1  Rab5-bind       Rabaptin-like protein


Domain annotation for each model (and alignments):
>> DNA_alkylation  DNA alkylation repair enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.4   0.2   5.9e-44   5.3e-40       1     213 []      12     250 ..      12     250 .. 0.89

  Alignments for each domain:
  == domain 1  score: 137.4 bits;  conditional E-value: 5.9e-44
  DNA_alkylation   1 ikaeLealadpekaeemqryfkegdeflGvkvpelrklakeffkelkle.....eelqelaeeLwksperEerllAldlltqak....kklaea. 85 
                     ++++L ++a+++ a++++ y+k+  +f+G+k+p ++k  k+ +k+  +      ++  ++  eL++s+++Ee+ +++++l        +    + 
      EFC36046.1  12 VRTTLLKVANKDSAKHQEGYMKNVIKFHGLKAPIVEKCWKDTLKSNLQTnipelKDQVDVSYELIASKYFEEKSIGIKILASNVknfvP----Kk 102
                     578999***********************************8887555469666555577779*****************887744441....23 PP

  DNA_alkylation  86 ................dlelyeklve...tinnWdlvDslaskivgalladkperrdllkeWaksenlWerRaAivatlklikk.tdlellleia 160
                                     +++ +e+++    ++  W+++D++ s+++ +l++++ +  +++++W  s+nlW++R A+v+++k +k+ +  +l+++i+
      EFC36046.1 103 kkksteddeigvnglyVVNGIEENLFdkeHVYDWATCDTISSTVICELIKRDSSLAQVVQKWKDSDNLWKQRSACVSFVKIAKHgEYNDLIIDIC 197
                     4446789*********99999998864568899***************************************************44455678*** PP

  DNA_alkylation 161 eelladkedfiqkAiGwaLrelsktdpdlveeFlekhakrmprlslreAiekl 213
                      ++++++e f q ++Gw+Lrels  d dlv++F+++++++++r  lr+A+ek+
      EFC36046.1 198 STTVKNSERFAQLGTGWVLRELSLADLDLVTDFIKENYSHFSREGLRYAVEKM 250
                     ***************************************************97 PP

>> Rab5-bind  Rabaptin-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   1.4e-05      0.13     158     237 ..      20      98 ..      10     113 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.4e-05
   Rab5-bind 158 esRtakdHlEekLkaEill..LkeqiqaEkalkEnlEetlqleierlkeelasisslkveleeikvekeslekslaektrql 237
                 + + ++ H E  +k+ i +  Lk+ i  Ek+ k+ l + lq++i +lk++++   s  + +++   ek    k la + +++
  EFC36046.1  20 ANKDSAKHQEGYMKNVIKFhgLKAPIV-EKCWKDTLKSNLQTNIPELKDQVDV--SYELIASKYFEEKSIGIKILASNVKNF 98 
                 5567899********999988999996.8***********************9..777777777777766556666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       840  (0.0468515); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1689.13
//
Query:       EFC36047.1  [L=787]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (787 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1056  (0.058899); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.50
# Mc/sec: 4759.34
//
Query:       EFC36048.1  [L=679]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.5e-29   99.3   8.8    3.3e-05   23.7   0.1    7.3  7  NHL             NHL repeat
    2.5e-09   37.3   0.4    2.5e-09   37.3   0.4    2.4  3  BTB             BTB/POZ domain
    1.3e-07   31.9   0.7         17    5.9   0.0    6.3  6  Linker_histone  linker histone H1 and H5 family
    0.00068   19.4   2.6        0.5   10.1   0.0    5.2  7  PCMT            Protein-L-isoaspartate(D-aspartate) O-methylt
      0.003   17.0  28.0        1.7    8.3   0.6    6.8  6  Plasmo_rep      Plasmodium repeat family
      0.005   16.7   0.0    1.7e+02    1.9   0.0    5.6  6  Maf             Maf-like protein
  ------ inclusion threshold ------
      0.011   15.8   3.1         43    4.3   0.0    5.0  5  DUF3420         Domain of unknown function (DUF3420)
      0.015   15.7   0.0         41    4.7   0.0    4.0  4  DUF4350         Domain of unknown function (DUF4350)
      0.035   13.2   8.1        5.1    6.0   0.1    3.9  3  Coatomer_WDAD   Coatomer WD associated region
      0.074   12.5   0.0    1.2e+02    2.1   0.0    4.8  6  KdpD            Osmosensitive K+ channel His kinase sensor do
       0.29   11.0   7.0         15    5.5   0.1    4.5  5  S4_2            S4 domain
        3.6    7.9  11.0         23    5.4   0.0    5.5  6  TRL             TRL-like protein family
        7.8    6.3  13.1        8.7    6.1   0.3    4.1  5  TPP_enzyme_C    Thiamine pyrophosphate enzyme, C-terminal TPP


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.1   2.4e-08   3.3e-05       3      27 ..      12      36 ..      12      37 .. 0.92
   2 !   17.7   0.0   1.9e-06    0.0026       1      27 [.      66      92 ..      66      93 .. 0.93
   3 !    9.5   0.0   0.00077       1.1       1      27 [.     122     148 ..     122     149 .. 0.94
   4 !   20.1   0.0   3.2e-07   0.00044       3      27 ..     180     204 ..     178     205 .. 0.84
   5 !   13.4   0.0   4.5e-05     0.061       1      27 [.     234     259 ..     234     260 .. 0.91
   6 !   13.4   0.0   4.5e-05     0.061       1      27 [.     289     314 ..     289     315 .. 0.91
   7 ?   -0.6   0.0       1.2   1.6e+03      16      25 ..     492     502 ..     492     503 .. 0.86

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 2.4e-08
                SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrvqv 27
                +P++v v+sn+++y+aD++nhr+++
  EFC36048.1 12 NPSSVFVSSNNEVYIADFCNHRIRK 36
                589999*****************97 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 1.9e-06
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                fnyP +v v+s +++y++D+ nh++++
  EFC36048.1 66 FNYPCSVFVSSKNEVYITDYSNHSIRK 92
                89999999*****************87 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00077
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P++v v+s +++y +D +n+r+++
  EFC36048.1 122 LYNPSSVFVSSKNEVYFTDQHNNRIRK 148
                 689**********************87 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 3.2e-07
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                 +P +v v+sn+++y++D+ nhr+++
  EFC36048.1 180 NPYSVFVSSNNEVYITDYSNHRIRK 204
                 55566689***************97 PP

  == domain 5  score: 13.4 bits;  conditional E-value: 4.5e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P++v v sn+++y++D  n+r+++
  EFC36048.1 234 LNRPNSVFV-SNNEVYISDQSNQRIRK 259
                 789999999.8**************87 PP

  == domain 6  score: 13.4 bits;  conditional E-value: 4.5e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P++v v sn+++y++D  n+r+++
  EFC36048.1 289 LNRPNSVFV-SNNEVYISDQSNQRIRK 314
                 789999999.8**************87 PP

  == domain 7  score: -0.6 bits;  conditional E-value: 1.2
                 EEEE.CCCTEE CS
         NHL  16 yVaD.senhrv 25 
                 y+ D  +nh++
  EFC36048.1 492 YILDqLNNHCI 502
                 788889****8 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       3.9   5.4e+03      57      91 ..     406     441 ..     389     452 .. 0.64
   2 ?   -2.6   0.0       4.6   6.4e+03      75      98 ..     468     491 ..     465     502 .. 0.78
   3 !   37.3   0.4   1.8e-12   2.5e-09       9     106 ..     564     664 ..     557     668 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 3.9
                 TTSGHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHH CS
         BTB  57 ddvepeafealLefiYtgeleit.seenleelLaaa 91 
                 +  + e++++l++ +  ++ +++ s+e++ ++L + 
  EFC36048.1 406 SSSQQEIIQKLIDSLLYDKNKVKfSKEEVLDVLFIL 441
                 455567777777777666666666677777777665 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 4.6
                 EEEC-CGGGHHHHHHHH.HHHT-HH CS
         BTB  75 eleitseenleelLaaa.dllqipr 98 
                 +l+++ +e++e+lL++  + + i++
  EFC36048.1 468 NLTFK-WETIENLLKTCkEEFGIQN 491
                 56775.9999999999877787776 PP

  == domain 3  score: 37.3 bits;  conditional E-value: 1.8e-12
                 TTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST....TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHH CS
         BTB   9 elcDvtlvvgdgkefkahkavLaarSpyFkalftsk....eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlkkac 103
                 + +Dv +++g++k +++hk vL+++S+ F+alf s+      ++++    + +  + e +e++++++Y+  ++  +  ++  lL +a + +i+ l++ c
  EFC36048.1 564 KTSDVKIKMGQNKYLYCHKTVLSSSSTLFNALFDSGscfsDLSDDGI-FTPDESEDLELLEIVIKYCYRISIDKIDAVKIIGLLDMAMKHEIQYLINYC 661
                 689*********************************76543344442.3555777889**********99988777899******************** PP

                 HHH CS
         BTB 104 eef 106
                 ++ 
  EFC36048.1 662 KNN 664
                 976 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0      0.03        42      33      67 ..      21      51 ..      15      57 .. 0.75
   2 ?    3.2   0.0     0.084   1.2e+02      41      69 ..      81     109 ..      67     113 .. 0.77
   3 ?    4.1   0.0     0.044        61      34      69 ..     134     165 ..     127     168 .. 0.81
   4 ?    2.8   0.0      0.11   1.5e+02      41      67 ..     193     219 ..     183     225 .. 0.74
   5 ?    2.3   0.0      0.16   2.2e+02      42      67 ..     249     274 ..     238     280 .. 0.77
   6 ?    5.9   0.0     0.012        17      42      69 ..     304     331 ..     293     334 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.03
  Linker_histone 33 kykvvdvskfksllkkalkkgvekgelvqpkgkGa 67
                    +++v     ++ ++++ ++k +e+g +v + g+G 
      EFC36048.1 21 NNEV----YIADFCNHRIRKILENGNIVTIAGNGN 51
                    4443....457789****************99664 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.084
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGasG 69 
                      ++ + ++ ++k +e+g ++ + g+G+ G
      EFC36048.1  81 YITDYSNHSIRKILENGNIITIAGNGTVG 109
                     45677899**************9977654 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.044
  Linker_histone  34 ykvvdvskfksllkkalkkgvekgelvqpkgkGasG 69 
                     +    +  f+ + ++ ++k +e+g ++ + g+G+ G
      EFC36048.1 134 N----EVYFTDQHNNRIRKILENGNIITIAGNGTYG 165
                     3....346788999****************988766 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.11
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGa 67 
                      ++ + ++ ++k +e+g +v + g+G 
      EFC36048.1 193 YITDYSNHRIRKILENGNIVTIAGNGN 219
                     456778999*************99664 PP

  == domain 5  score: 2.3 bits;  conditional E-value: 0.16
  Linker_histone  42 fksllkkalkkgvekgelvqpkgkGa 67 
                     ++ + ++ ++k +e+g ++ + g+G 
      EFC36048.1 249 ISDQSNQRIRKILENGNIITIAGNGN 274
                     5678899**************99664 PP

  == domain 6  score: 5.9 bits;  conditional E-value: 0.012
  Linker_histone  42 fksllkkalkkgvekgelvqpkgkGasG 69 
                     ++ + ++ ++k +e+g +v + g+G++G
      EFC36048.1 304 ISDQSNQRIRKILENGNIVTIAGNGTAG 331
                     567889*****************99988 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.78   1.1e+03      95     138 ..      11      55 ..       5      60 .. 0.72
   2 ?   -1.6   0.0       1.4   1.9e+03     111     138 ..      83     111 ..      71     116 .. 0.71
   3 ?   -0.1   0.0      0.47   6.5e+02     110     138 ..     138     167 ..     115     172 .. 0.71
   4 ?    0.3   0.0      0.36     5e+02     102     138 ..     186     223 ..     173     229 .. 0.76
   5 ?    2.1   0.0       0.1   1.4e+02     110     138 ..     249     278 ..     228     286 .. 0.81
   6 !   10.1   0.0   0.00036       0.5     110     147 ..     304     342 ..     283     350 .. 0.83
   7 ?   -3.3   0.0       4.6   6.4e+03      88     109 ..     529     550 ..     528     575 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.78
                 HCTTCEEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT  95 vgekgrvvsierikelveeakrnlkkldle.nvivvvgDGrkGye 138
                 ++++   vs +    +++  +++++k   + n++++ g G++G+ 
  EFC36048.1  11 FNPSSVFVSSNNEVYIADFCNHRIRKILENgNIVTIAGNGNYGFS 55 
                 5555555666666667777788888865555************96 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.4
                 HHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 111 veeakrnlkkldle.nvivvvgDGrkGye 138
                 ++ +++ ++k   + n+i++ g G+ G+ 
  EFC36048.1  83 TDYSNHSIRKILENgNIITIAGNGTVGFS 111
                 4556666666544459***********97 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.47
                 HHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 110 lveeakrnlkkldle.nvivvvgDGrkGye 138
                 ++++ +++++k   + n+i++ g G++G+ 
  EFC36048.1 138 FTDQHNNRIRKILENgNIITIAGNGTYGFS 167
                 4556667777754446************96 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.36
                 EEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 102 vsierikelveeakrnlkkldle.nvivvvgDGrkGye 138
                 vs +    +++ ++++++k   + n++++ g G++G+ 
  EFC36048.1 186 VSSNNEVYITDYSNHRIRKILENgNIVTIAGNGNYGFS 223
                 555555667788999999865556************96 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.1
                 HHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 110 lveeakrnlkkldle.nvivvvgDGrkGye 138
                 + ++++++++k   + n+i++ g G++G+ 
  EFC36048.1 249 ISDQSNQRIRKILENgNIITIAGNGNYGFS 278
                 6789999999976556************96 PP

  == domain 6  score: 10.1 bits;  conditional E-value: 0.00036
                 HHHHHHHHHHHCTTC.SEEEEES-GGGTTGGG-SEEEEE CS
        PCMT 110 lveeakrnlkkldle.nvivvvgDGrkGyeekaPYdaih 147
                 + ++++++++k   + n++++ g G+ G+   +P++ i+
  EFC36048.1 304 ISDQSNQRIRKILENgNIVTIAGNGTAGFSGDSPFNIIM 342
                 6789999999976556********************997 PP

  == domain 7  score: -3.3 bits;  conditional E-value: 4.6
                 HHHHHHHHCTTCEEEEEESBHH CS
        PCMT  88 tavlarlvgekgrvvsierike 109
                 ta++ +++ ++ +++ ie + e
  EFC36048.1 529 TAIFPKMIITEPTAINIEETIE 550
                 8999999999999999997655 PP

>> Plasmo_rep  Plasmodium repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1     0.016        22       1       8 [.      19      26 ..      19      28 .. 0.86
   2 ?    2.8   0.2     0.064        88       2      11 ..      76      85 ..      75      86 .. 0.82
   3 ?    0.1   0.1      0.45   6.1e+02       2      11 ..     132     141 ..     131     142 .. 0.74
   4 !    8.0   0.8    0.0015         2       1      11 [.     187     197 ..     187     198 .. 0.90
   5 !    8.3   0.6    0.0012       1.7       2      11 ..     243     252 ..     243     253 .. 0.95
   6 !    8.3   0.6    0.0012       1.7       2      11 ..     298     307 ..     298     308 .. 0.95

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.016
  Plasmo_rep  1 FsDnEvYs 8 
                +s+nEvY+
  EFC36048.1 19 SSNNEVYI 26
                69*****8 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.064
  Plasmo_rep  2 sDnEvYspkq 11
                s nEvY++++
  EFC36048.1 76 SKNEVYITDY 85
                679****995 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.45
  Plasmo_rep   2 sDnEvYspkq 11 
                 s nEvY ++q
  EFC36048.1 132 SKNEVYFTDQ 141
                 5689998876 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0015
  Plasmo_rep   1 FsDnEvYspkq 11 
                 +s+nEvY++++
  EFC36048.1 187 SSNNEVYITDY 197
                 6********95 PP

  == domain 5  score: 8.3 bits;  conditional E-value: 0.0012
  Plasmo_rep   2 sDnEvYspkq 11 
                 s+nEvY+++q
  EFC36048.1 243 SNNEVYISDQ 252
                 9********8 PP

  == domain 6  score: 8.3 bits;  conditional E-value: 0.0012
  Plasmo_rep   2 sDnEvYspkq 11 
                 s+nEvY+++q
  EFC36048.1 298 SNNEVYISDQ 307
                 9********8 PP

>> Maf  Maf-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.83   1.2e+03      97     128 ..      17      48 ..       2      59 .. 0.75
   2 ?    0.1   0.0      0.45   6.3e+02      99     128 ..      75     104 ..      65     112 .. 0.88
   3 ?    1.9   0.0      0.13   1.7e+02      99     128 ..     131     160 ..     117     175 .. 0.80
   4 ?    0.4   0.0      0.38   5.2e+02      99     128 ..     187     216 ..     173     229 .. 0.82
   5 ?    1.9   0.0      0.12   1.7e+02      96     128 ..     239     271 ..     229     281 .. 0.85
   6 ?    1.8   0.0      0.14     2e+02      96     128 ..     294     326 ..     281     333 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.83
                 EEEEEEEEEE----HHHHHHHHHCTSGCCSTT CS
         Maf  97 sfvettevtfkelsdeeieaYvatgepldkAG 128
                   +++ ev+++++ ++ i++ +++g+ +  AG
  EFC36048.1  17 FVSSNNEVYIADFCNHRIRKILENGNIVTIAG 48 
                 3457889******************9998887 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.45
                 EEEEEEEE----HHHHHHHHHCTSGCCSTT CS
         Maf  99 vettevtfkelsdeeieaYvatgepldkAG 128
                 +++ ev++ + s++ i++ +++g+ +  AG
  EFC36048.1  75 SSKNEVYITDYSNHSIRKILENGNIITIAG 104
                 46789*******************999998 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.13
                 EEEEEEEE----HHHHHHHHHCTSGCCSTT CS
         Maf  99 vettevtfkelsdeeieaYvatgepldkAG 128
                 +++ ev+f + +++ i++ +++g+ +  AG
  EFC36048.1 131 SSKNEVYFTDQHNNRIRKILENGNIITIAG 160
                 57899*******************988887 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.38
                 EEEEEEEE----HHHHHHHHHCTSGCCSTT CS
         Maf  99 vettevtfkelsdeeieaYvatgepldkAG 128
                 +++ ev++ + s++ i++ +++g+ +  AG
  EFC36048.1 187 SSNNEVYITDYSNHRIRKILENGNIVTIAG 216
                 56789*******************998887 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.12
                 .EEEEEEEEEE----HHHHHHHHHCTSGCCSTT CS
         Maf  96 ksfvettevtfkelsdeeieaYvatgepldkAG 128
                   fv++ ev++++ s++ i++ +++g+ +  AG
  EFC36048.1 239 SVFVSNNEVYISDQSNQRIRKILENGNIITIAG 271
                 5688999********************999887 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.14
                 .EEEEEEEEEE----HHHHHHHHHCTSGCCSTT CS
         Maf  96 ksfvettevtfkelsdeeieaYvatgepldkAG 128
                   fv++ ev++++ s++ i++ +++g+ +  AG
  EFC36048.1 294 SVFVSNNEVYISDQSNQRIRKILENGNIVTIAG 326
                 5688999********************999998 PP

>> DUF3420  Domain of unknown function (DUF3420)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.92   1.3e+03      36      47 .]      27      38 ..      18      38 .. 0.80
   2 ?    1.3   0.0      0.28   3.8e+02      36      47 .]     139     150 ..     130     150 .. 0.83
   3 ?    0.6   0.0      0.47   6.4e+02      36      47 .]     195     206 ..     186     206 .. 0.81
   4 ?    4.3   0.0     0.032        43      35      47 .]     249     261 ..     241     261 .. 0.87
   5 ?    4.3   0.0     0.032        43      35      47 .]     304     316 ..     296     316 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.92
     DUF3420 36 ddleekrirril 47
                 d+ + rir+il
  EFC36048.1 27 ADFCNHRIRKIL 38
                688899*****7 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.28
     DUF3420  36 ddleekrirril 47 
                  d ++ rir+il
  EFC36048.1 139 TDQHNNRIRKIL 150
                 5899*******7 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.47
     DUF3420  36 ddleekrirril 47 
                  d ++ rir+il
  EFC36048.1 195 TDYSNHRIRKIL 206
                 6889*******7 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.032
     DUF3420  35 lddleekrirril 47 
                 ++d +++rir+il
  EFC36048.1 249 ISDQSNQRIRKIL 261
                 4899********7 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.032
     DUF3420  35 lddleekrirril 47 
                 ++d +++rir+il
  EFC36048.1 304 ISDQSNQRIRKIL 316
                 4899********7 PP

>> DUF4350  Domain of unknown function (DUF4350)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0       0.7   9.7e+02      39      63 ..     130     154 ..     112     160 .. 0.77
   2 ?   -1.3   0.0       2.3   3.1e+03      38      65 ..     185     212 ..     172     216 .. 0.75
   3 ?    4.6   0.0     0.033        46      31      64 ..     233     266 ..     212     271 .. 0.82
   4 ?    4.7   0.0     0.029        41      33      65 ..     290     322 ..     276     326 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.7
     DUF4350  39 lvvapdlrlteeelaallewvarGn 63 
                 +   +++++t++  +++++ +++Gn
  EFC36048.1 130 VSSKNEVYFTDQHNNRIRKILENGN 154
                 444567999999999*********9 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 2.3
     DUF4350  38 llvvapdlrlteeelaallewvarGntl 65 
                 ++  ++++++t+ +  ++++ +++Gn +
  EFC36048.1 185 FVSSNNEVYITDYSNHRIRKILENGNIV 212
                 5555677888887778999999999965 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.033
     DUF4350  31 legedgtllvvapdlrlteeelaallewvarGnt 64 
                 +  +++ ++v ++++++++++ +++++ +++Gn 
  EFC36048.1 233 QLNRPNSVFVSNNEVYISDQSNQRIRKILENGNI 266
                 4457778999**********************95 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.029
     DUF4350  33 gedgtllvvapdlrlteeelaallewvarGntl 65 
                  +++ ++v ++++++++++ +++++ +++Gn +
  EFC36048.1 290 NRPNSVFVSNNEVYISDQSNQRIRKILENGNIV 322
                 46778999**********************965 PP

>> Coatomer_WDAD  Coatomer WD associated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   1.2     0.036        50      42      98 ..      39      95 ..      22     200 .. 0.80
   2 ?    6.0   0.1    0.0037       5.1      42      91 ..     207     257 ..     194     263 .. 0.85
   3 ?    5.8   0.1    0.0044       6.1      42      95 ..     262     314 ..     258     329 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.036
                   XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXX.XXXX CS
  Coatomer_WDAD 42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvs.snrfavlessksvkifknfk 98
                   +ng++v++ g+g+y +    +  ++a+ +    v+vs +n++ +++  ++ +i k ++
     EFC36048.1 39 ENGNIVTIAGNGNYGFSGDNGPATNAQFNYPCSVFVSsKNEVYITD-YSNHSIRKILE 95
                   6899999999999999999999999999999999999544444443.33344433334 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0037
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXX CS
  Coatomer_WDAD  42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavles.sksv 91 
                    +ng++v++ g+g+y +    +  ++a+ +  + v+vs+n++ + ++ ++ +
     EFC36048.1 207 ENGNIVTIAGNGNYGFSGDNGPATNAQLNRPNSVFVSNNEVYISDQsNQRI 257
                    79***********************************99977777624444 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0044
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.X CS
  Coatomer_WDAD  42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvkifk 95 
                    +ng+++++ g+g+y +    +  ++a+ +  + v+vs+n++ + ++s + +i k
     EFC36048.1 262 ENGNIITIAGNGNYGFSGDNGPATNAQLNRPNSVFVSNNEVYISDQS-NQRIRK 314
                    69***********************************9997777753.345533 PP

>> KdpD  Osmosensitive K+ channel His kinase sensor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.6   2.1e+03     150     177 ..      17      44 ..      12      47 .. 0.85
   2 ?   -0.9   0.0      0.66   9.1e+02     150     177 ..      73     100 ..      67     104 .. 0.86
   3 ?   -1.8   0.0       1.3   1.8e+03     150     177 ..     129     156 ..     124     159 .. 0.81
   4 ?   -0.6   0.0      0.55   7.6e+02     150     177 ..     185     212 ..     181     216 .. 0.87
   5 ?    1.8   0.0       0.1   1.4e+02     147     177 ..     237     267 ..     229     272 .. 0.90
   6 ?    2.1   0.0     0.085   1.2e+02     147     178 ..     292     323 ..     284     330 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.6
        KdpD 150 vleeAdevelvDltpeeLlerLkegkvy 177
                 ++++ +ev + D   +++++ L++g++ 
  EFC36048.1  17 FVSSNNEVYIADFCNHRIRKILENGNIV 44 
                 567789999****************996 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.66
        KdpD 150 vleeAdevelvDltpeeLlerLkegkvy 177
                 ++++ +ev + D + +++++ L++g++ 
  EFC36048.1  73 FVSSKNEVYITDYSNHSIRKILENGNII 100
                 5677789999***************996 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.3
        KdpD 150 vleeAdevelvDltpeeLlerLkegkvy 177
                 ++++ +ev + D + +++++ L++g++ 
  EFC36048.1 129 FVSSKNEVYFTDQHNNRIRKILENGNII 156
                 4567789999999999999999999986 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 0.55
        KdpD 150 vleeAdevelvDltpeeLlerLkegkvy 177
                 ++++ +ev + D + +++++ L++g++ 
  EFC36048.1 185 FVSSNNEVYITDYSNHRIRKILENGNIV 212
                 5678899******************996 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.1
        KdpD 147 PdevleeAdevelvDltpeeLlerLkegkvy 177
                 P++v+ + +ev + D + +++++ L++g++ 
  EFC36048.1 237 PNSVFVSNNEVYISDQSNQRIRKILENGNII 267
                 9999************************996 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.085
        KdpD 147 PdevleeAdevelvDltpeeLlerLkegkvyk 178
                 P++v+ + +ev + D + +++++ L++g++ +
  EFC36048.1 292 PNSVFVSNNEVYISDQSNQRIRKILENGNIVT 323
                 999*************************9975 PP

>> S4_2  S4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       2.3   3.1e+03      44      59 ..      33      48 ..      20      52 .. 0.67
   2 ?    0.8   0.0      0.31   4.3e+02      32      60 ..     133     161 ..     129     165 .. 0.81
   3 ?   -1.1   0.0       1.2   1.7e+03      33      59 ..     190     216 ..     185     220 .. 0.70
   4 ?    4.4   0.1     0.024        32      29      59 ..     241     271 ..     239     275 .. 0.89
   5 ?    5.5   0.1     0.011        15      29      60 ..     296     327 ..     294     330 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.3
        S4_2 44 rRgkKlraGdvVeidg 59
                r +k l +G +V+i+g
  EFC36048.1 33 RIRKILENGNIVTIAG 48
                3444567899999965 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.31
        S4_2  32 egeVkvNGevetrRgkKlraGdvVeidge 60 
                 ++eV + ++  +r +k l +G +++i+g+
  EFC36048.1 133 KNEVYFTDQHNNRIRKILENGNIITIAGN 161
                 578888899999999999********543 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 1.2
        S4_2  33 geVkvNGevetrRgkKlraGdvVeidg 59 
                 +eV + +    r +k l +G +V+i+g
  EFC36048.1 190 NEVYITDYSNHRIRKILENGNIVTIAG 216
                 56666666666777778899***9965 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.024
        S4_2  29 fiaegeVkvNGevetrRgkKlraGdvVeidg 59 
                 f++++eV + ++  +r +k l +G +++i+g
  EFC36048.1 241 FVSNNEVYISDQSNQRIRKILENGNIITIAG 271
                 899**************************65 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.011
        S4_2  29 fiaegeVkvNGevetrRgkKlraGdvVeidge 60 
                 f++++eV + ++  +r +k l +G +V+i+g+
  EFC36048.1 296 FVSNNEVYISDQSNQRIRKILENGNIVTIAGN 327
                 899**************************764 PP

>> TRL  TRL-like protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0       0.3   4.1e+02      28      54 ..      21      47 ..      12      48 .. 0.86
   2 ?    5.4   0.0     0.016        23      27      54 ..      76     103 ..      56     107 .. 0.86
   3 ?    0.4   0.0      0.58   7.9e+02      32      54 ..     137     159 ..     112     160 .. 0.77
   4 ?    1.7   0.0      0.23   3.2e+02      26      54 ..     187     215 ..     164     216 .. 0.82
   5 ?   -0.5   0.2       1.1   1.6e+03      37      54 ..     253     270 ..     243     271 .. 0.81
   6 ?   -1.1   0.1       1.7   2.4e+03      37      54 ..     308     325 ..     298     326 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.3
         TRL 28 ksiLglvstGdaSieaaaknggItkia 54
                ++  ++  + +  i+++ +ng+I +ia
  EFC36048.1 21 NNEVYIADFCNHRIRKILENGNIVTIA 47
                5667888999*************9996 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.016
         TRL  27 aksiLglvstGdaSieaaaknggItkia 54 
                 +k+  ++  + + Si+++ +ng+I +ia
  EFC36048.1  76 SKNEVYITDYSNHSIRKILENGNIITIA 103
                 5667788999**************9996 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.58
         TRL  32 glvstGdaSieaaaknggItkia 54 
                 ++    ++ i+++ +ng+I +ia
  EFC36048.1 137 YFTDQHNNRIRKILENGNIITIA 159
                 44445789999********9996 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.23
         TRL  26 caksiLglvstGdaSieaaaknggItkia 54 
                 ++++  ++  + +  i+++ +ng+I +ia
  EFC36048.1 187 SSNNEVYITDYSNHRIRKILENGNIVTIA 215
                 556667888999*************9986 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 1.1
         TRL  37 GdaSieaaaknggItkia 54 
                  ++ i+++ +ng+I +ia
  EFC36048.1 253 SNQRIRKILENGNIITIA 270
                 688999********9996 PP

  == domain 6  score: -1.1 bits;  conditional E-value: 1.7
         TRL  37 GdaSieaaaknggItkia 54 
                  ++ i+++ +ng+I +ia
  EFC36048.1 308 SNQRIRKILENGNIVTIA 325
                 6788999*******9986 PP

>> TPP_enzyme_C  Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       2.6   3.6e+03      48      79 ..      42      74 ..      36      82 .. 0.70
   2 ?   -2.4   0.0       2.7   3.8e+03      48      85 ..      98     137 ..      91     148 .. 0.58
   3 ?    0.6   0.1      0.31   4.3e+02      47      85 ..     153     193 ..     145     201 .. 0.73
   4 ?    6.1   0.3    0.0063       8.7      47      85 ..     209     248 ..     203     260 .. 0.86
   5 ?    6.0   0.2    0.0068       9.3      47      85 ..     264     303 ..     256     317 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.6
                  EEEEEEEHHHHHHT.GGGHHHHHHTT-SEEEEE CS
  TPP_enzyme_C 48 evvaivGDGgflmi.lqelatavrrnlpitvvv 79
                  ++v i+G G + ++  +  at ++ n p  v+v
    EFC36048.1 42 NIVTIAGNGNYGFSgDNGPATNAQFNYPCSVFV 74
                  789999999999995577888888887665544 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.7
                   EEEEEEEHHHHHHT.GGGHHHHHH.TT-SEEEEEEE-SBC CS
  TPP_enzyme_C  48 evvaivGDGgflmi.lqelatavr.rnlpitvvvlnNegy 85 
                   +++ i+G G+  ++  +  at ++ +n   ++v   Ne+y
    EFC36048.1  98 NIITIAGNGTVGFSgDSGPATNAQlYNPSSVFVSSKNEVY 137
                   6777888888777742334444431333555555555555 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.31
                   SEEEEEEEHHHHHHT.GGGHHHHHHTT-SEEEEE.EE-SBC CS
  TPP_enzyme_C  47 revvaivGDGgflmi.lqelatavrrnlpitvvv.lnNegy 85 
                    +++ i+G G++ ++  +  at ++   p  v+v  nNe+y
    EFC36048.1 153 GNIITIAGNGTYGFSgDNGPATNAQLYNPYSVFVsSNNEVY 193
                   47999******999965888888887776655551555555 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0063
                   SEEEEEEEHHHHHHT.GGGHHHHHHTT-SEEEEEEE-SBC CS
  TPP_enzyme_C  47 revvaivGDGgflmi.lqelatavrrnlpitvvvlnNegy 85 
                    ++v i+G G + ++  +  at ++ n p  v+v nNe+y
    EFC36048.1 209 GNIVTIAGNGNYGFSgDNGPATNAQLNRPNSVFVSNNEVY 248
                   4899***********779*********************9 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.0068
                   SEEEEEEEHHHHHHT.GGGHHHHHHTT-SEEEEEEE-SBC CS
  TPP_enzyme_C  47 revvaivGDGgflmi.lqelatavrrnlpitvvvlnNegy 85 
                    +++ i+G G + ++  +  at ++ n p  v+v nNe+y
    EFC36048.1 264 GNIITIAGNGNYGFSgDNGPATNAQLNRPNSVFVSNNEVY 303
                   4899***********7799********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (679 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       874  (0.0487478); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.46
# Mc/sec: 4434.94
//
Query:       EFC36049.1  [L=614]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00063   19.8   0.0     0.0013   18.9   0.0    1.4  1  TPR_9           Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.013   15.8   0.0      0.031   14.6   0.0    1.6  1  TPR_12          Tetratricopeptide repeat
      0.014   15.2   0.0      0.034   14.0   0.0    1.7  1  TPR_1           Tetratricopeptide repeat
      0.027   14.6   0.0      0.083   13.0   0.0    1.9  2  TPR_2           Tetratricopeptide repeat
      0.036   13.7   3.4      0.087   12.5   3.4    1.7  1  YkyA            Putative cell-wall binding lipoprotein
      0.042   14.7   0.1       0.19   12.7   0.0    2.1  2  TPR_14          Tetratricopeptide repeat
       0.05   13.5   1.7        2.4    8.2   0.0    2.9  3  TPR_10          Tetratricopeptide repeat
      0.057   13.7   0.2       0.37   11.1   0.0    2.5  2  TPR_8           Tetratricopeptide repeat
       0.08   13.8   0.2       0.21   12.4   0.2    1.7  1  CTD_bind        RNA polymerase II-binding domain.
       0.12   12.6   0.1       0.35   11.0   0.1    1.8  1  Alpha-mann_mid  Alpha mannosidase middle domain
        4.3    7.8   5.6        2.4    8.6   0.1    3.2  3  PPR             PPR repeat


Domain annotation for each model (and alignments):
>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   7.8e-07    0.0013       6      54 ..     431     479 ..     427     491 .. 0.92

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 7.8e-07
       TPR_9   6 ireedweralavverllllaPddpeerrdRGlllaqlGclsaAladLea 54 
                  ++e+ e a +v er+  ++  +p+ +rd +l+ +++G +++A++ +++
  EFC36049.1 431 DQAEELELAEWVFERVKSINGFEPQSYRDLALVKERMGKYEEAMELFNR 479
                 58999**************************************987766 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   1.9e-05     0.031      46      71 ..     455     480 ..     442     481 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.9e-05
      TPR_12  46 ttlrnLgrlyralgryeeAlelleea 71 
                 +++r+L+ + +++g+yeeA el++++
  EFC36049.1 455 QSYRDLALVKERMGKYEEAMELFNRV 480
                 6899******************9997 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   2.1e-05     0.034       3      28 ..     456     481 ..     454     482 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.1e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekAL 28 
                 ++  l+++  ++gky+eA e +++++
  EFC36049.1 456 SYRDLALVKERMGKYEEAMELFNRVI 481
                 678899999**************987 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       8.6   1.4e+04      18      28 ..     277     287 ..     277     289 .. 0.82
   2 ?   13.0   0.0   5.1e-05     0.083       3      28 ..     456     481 ..     454     482 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 8.6
       TPR_2  18 eeAleafekAl 28 
                 ee +e+++++ 
  EFC36049.1 277 EESRECCRECC 287
                 78999999986 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 5.1e-05
       TPR_2   3 alynlGlayyklgdyeeAleafekAl 28 
                  +  l+l+ +++g+yeeA e+f++++
  EFC36049.1 456 SYRDLALVKERMGKYEEAMELFNRVI 481
                 68899******************986 PP

>> YkyA  Putative cell-wall binding lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   3.4   5.3e-05     0.087      75     119 ..     192     236 ..     140     252 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.3e-05
        YkyA  75 esieeakeefekikeeieeiedeelkkeaeelieameeryeaydk 119
                 + + e +++f ++k++ +e +d++ k+++e  i+ ++er + +++
  EFC36049.1 192 KTLTEVYKQFMQVKTSAQEAKDKQEKEKLERIISMWKERVNWHKT 236
                 678999*********************************999986 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       8.3   1.3e+04      10      26 ..     429     445 ..     421     448 .. 0.69
   2 ?   12.7   0.0   0.00011      0.19       2      28 ..     455     481 ..     454     489 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 8.3
      TPR_14  10 allalGdpdeAiallrr 26 
                  l ++++++ A+ +++r
  EFC36049.1 429 RLDQAEELELAEWVFER 445
                 45677788888888887 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 0.00011
      TPR_14   2 eallalaeallalGdpdeAiallrral 28 
                 + +++la + ++ G+++eA++l++r++
  EFC36049.1 455 QSYRDLALVKERMGKYEEAMELFNRVI 481
                 6799*********************97 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0      0.04        66      14      36 ..     210     231 ..     207     239 .. 0.85
   2 ?   -3.5   0.1       6.9   1.1e+04      16      24 ..     428     436 ..     428     438 .. 0.84
   3 ?    8.2   0.0    0.0015       2.4       4      29 ..     456     481 ..     455     482 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.04
      TPR_10  14 qrgrydeAealleealairrrll 36 
                 + ++ +e e+l e+ ++++++ +
  EFC36049.1 210 EAKDKQEKEKL-ERIISMWKERV 231
                 66899******.********976 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 6.9
      TPR_10  16 grydeAeal 24 
                 +r+d+Ae+l
  EFC36049.1 428 YRLDQAEEL 436
                 699****98 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0015
      TPR_10   4 slnNLanalrqrgrydeAealleeal 29 
                 s+ +La +  ++g+y+eA++l+ +++
  EFC36049.1 456 SYRDLALVKERMGKYEEAMELFNRVI 481
                 7899*****************97775 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       2.4   3.9e+03      18      29 ..     277     288 ..     277     290 .. 0.87
   2 ?   11.1   0.0   0.00023      0.37       6      28 ..     459     481 ..     454     481 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 2.4
                 HHHHHHHHHHHH CS
       TPR_8  18 eeAkeyyekale 29 
                 ee+ e+++++++
  EFC36049.1 277 EESRECCRECCR 288
                 799*******86 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00023
                 HHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   6 nlgsiylklgdyeeAkeyyekal 28 
                  l+++ + +g+yeeA+e +++++
  EFC36049.1 459 DLALVKERMGKYEEAMELFNRVI 481
                 699999*************9986 PP

>> CTD_bind  RNA polymerase II-binding domain.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.2   0.00013      0.21      39      60 ..     208     230 ..     186     231 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00013
    CTD_bind  39 yk.kapekikkklkrllniWeer 60 
                 ++  ++++ k+kl+r+++ W+er
  EFC36049.1 208 AQeAKDKQEKEKLERIISMWKER 230
                 224567999*************9 PP

>> Alpha-mann_mid  Alpha mannosidase middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   0.00022      0.35      51      81 ..     178     208 ..     168     223 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00022
                     HHHHHHTCTTTTTT-S-HHHHHHCCHHHHHH CS
  Alpha-mann_mid  51 kalllnqfHDilpGtsieeVyedaeerlaea 81 
                     ++l  +q HDi+p    +eVy++ ++  + a
      EFC36049.1 178 ETLSQYQKHDIVPPKTLTEVYKQFMQVKTSA 208
                     78999*****************988654444 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.4       2.7   4.4e+03       7      19 ..     270     282 ..     270     284 .. 0.84
   2 ?   -0.3   0.0       1.1   1.7e+03      14      28 ..     434     448 ..     432     450 .. 0.82
   3 ?    8.6   0.1    0.0015       2.4      12      25 ..     466     479 ..     465     482 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2.7
         PPR   7 IsgycknGkleeA 19 
                 ++++c++ + +e+
  EFC36049.1 270 LDSCCRCEESREC 282
                 589****999987 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 1.1
         PPR  14 GkleeAlelfkeMke 28 
                  +le A+++f++ k+
  EFC36049.1 434 EELELAEWVFERVKS 448
                 67899******9886 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0015
         PPR  12 knGkleeAlelfke 25 
                 + Gk+eeA+elf++
  EFC36049.1 466 RMGKYEEAMELFNR 479
                 78**********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (614 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1507  (0.0840538); expected 358.6 (0.02)
Passed bias filter:                      600  (0.0334653); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.78u 0.33s 00:00:01.11 Elapsed: 00:00:00.53
# Mc/sec: 3469.95
//
Query:       EFC36050.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       679  (0.0378716); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.43
# Mc/sec: 3524.49
//
Query:       EFC36051.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.1e-08   33.8   2.5       0.76   10.5   0.0    6.1  6  Ank_3          Ankyrin repeat
    5.2e-08   33.0   0.1       0.62   10.5   0.0    4.7  5  Ank_5          Ankyrin repeats (many copies)
    1.9e-06   28.3   1.8      0.013   16.1   0.0    4.5  5  Ank_4          Ankyrin repeats (many copies)
    4.3e-06   27.2   3.0      0.001   19.6   0.1    3.6  4  Ank_2          Ankyrin repeats (3 copies)
    0.00036   20.9  10.5        4.2    8.0   0.0    5.5  5  Ank            Ankyrin repeat
  ------ inclusion threshold ------
       0.02   14.3   0.0      0.029   13.8   0.0    1.2  1  Peripla_BP_1   Periplasmic binding proteins and sugar binding
       0.16   12.6   8.6        1.4    9.5   3.1    2.3  2  Ribosomal_L6e  Ribosomal protein L6e
       0.68    9.6   7.7        3.4    7.3   4.9    2.2  2  FAM176         FAM176 family
        8.4    6.8  12.7       0.23   11.8   2.5    2.4  2  Orf78          Orf78 (ac78)


Domain annotation for each model (and alignments):
>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0       1.1   2.3e+03      11      28 ..      50      67 ..      45      68 .. 0.68
   2 ?    3.3   0.0     0.086   1.7e+02      17      31 .]     103     116 ..      96     116 .. 0.84
   3 !   10.5   0.0   0.00038      0.76       4      30 ..     131     156 ..     130     157 .. 0.93
   4 !    7.0   0.0    0.0056        11       6      30 ..     177     200 ..     175     201 .. 0.86
   5 ?    2.6   0.0      0.15   2.9e+02       3      11 ..     219     227 ..     218     244 .. 0.87
   6 ?    3.8   0.0     0.061   1.2e+02      15      30 ..     269     284 ..     262     285 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 1.1
       Ank_3 11 rsgnleivkfLlenkgad 28
                 + +++++k+Ll +kga+
  EFC36051.1 50 INRDFNRLKLLLIEKGAN 67
                455666677777668887 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.086
       Ank_3  17 ivkfLlenkgadvna 31 
                  +++Ll  kga+vna
  EFC36051.1 103 AIELLLS-KGANVNA 116
                 5999***.9****96 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.00038
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 t++ ++++ +n+e++k++l+ +gad n
  EFC36051.1 131 TAFEIVLSKNNIELIKLFLK-YGADSN 156
                 88999***************.****88 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0056
       Ank_3   6 LhlAarsgnleivkfLlenkgadvn 30 
                 L++ +++gnl++ k Lle ++a+ n
  EFC36051.1 177 LYQSVKYGNLDLFKCLLE-HNANTN 200
                 667899************.898876 PP

  == domain 5  score: 2.6 bits;  conditional E-value: 0.15
       Ank_3   3 etpLhlAar 11 
                 e pLhlA++
  EFC36051.1 219 ELPLHLACK 227
                 569*****7 PP

  == domain 6  score: 3.8 bits;  conditional E-value: 0.061
       Ank_3  15 l.eivkfLlenkgadvn 30 
                 + e++ +L++ ++ d+n
  EFC36051.1 269 YkEMILLLIK-YNSDIN 284
                 33599*****.*****9 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       5.5   1.1e+04      23      42 ..      49      68 ..      44      70 .. 0.61
   2 !   10.5   0.0   0.00031      0.62       1      47 [.     107     160 ..     107     165 .. 0.88
   3 !   10.0   0.0   0.00044      0.87      20      45 ..     177     202 ..     160     208 .. 0.88
   4 ?    3.9   0.0     0.036        71      11      26 ..     218     229 ..     210     237 .. 0.71
   5 ?    2.7   0.0     0.082   1.6e+02      31      46 ..     272     287 ..     268     293 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 5.5
       Ank_5 23 AakygaadvvrlLlargadl 42
                A+++   ++ +lL++ ga++
  EFC36051.1 49 AINRDFNRLKLLLIEKGANA 68
                55555555555666888775 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00031
       Ank_5   1 Llehgpadvnrldgggn........tpLhvAakygaadvvrlLlargadlnltds 47 
                 Ll++g a+vn+  g +n        t++ +  ++++ ++++l+l++gad n++ +
  EFC36051.1 107 LLSKG-ANVNAIYGSSNwkgsgssgTAFEIVLSKNNIELIKLFLKYGADSNTCQK 160
                 67778.8888888888888888889************************998876 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00044
       Ank_5  20 LhvAakygaadvvrlLlargadlnlt 45 
                 L +++kyg++d+++ Ll+++a++nl 
  EFC36051.1 177 LYQSVKYGNLDLFKCLLEHNANTNLF 202
                 7789*******************986 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.036
       Ank_5  11 rldgggntpLhvAak.y 26 
                       ++pLh+A+k  
  EFC36051.1 218 K-----ELPLHLACKlF 229
                 3.....39******955 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.082
       Ank_5  31 vvrlLlargadlnltd 46 
                 +++lL+++++d+n++ 
  EFC36051.1 272 MILLLIKYNSDINMYG 287
                 556666*******986 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.81   1.6e+03       5      26 ..      46      67 ..      43      76 .. 0.58
   2 !   16.1   0.0   6.4e-06     0.013       4      55 .]      86     149 ..      83     149 .. 0.81
   3 !    9.5   0.0   0.00073       1.5       7      55 .]     135     193 ..     129     193 .. 0.72
   4 ?    5.9   0.1      0.01        20      10      44 ..     182     227 ..     175     237 .. 0.70
   5 ?    0.8   0.0       0.4   7.9e+02      14      29 ..     270     285 ..     266     290 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.81
       Ank_4  5 LhyaaisgrlelvrlLlekgad 26
                L++a++    +l  lL+ekga+
  EFC36051.1 46 LDSAINRDFNRLKLLLIEKGAN 67
                6666664444444456677776 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 6.4e-06
       Ank_4   4 aLhyaai.....sgrlelvrlLlekgadinaq...dn....rsGetalhiAakrgnveilklLl 55 
                 ++h+        ++++++++lLl+kga++na    +n    +s  ta+ i+++++n+e +kl+l
  EFC36051.1  86 VIHKVLLgwddmKEQMQAIELLLSKGANVNAIygsSNwkgsGSSGTAFEIVLSKNNIELIKLFL 149
                 666666666666899*************999987655554455779****************97 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00073
       Ank_4   7 yaaisgrlelvrlLlekgadinaqdnrs..........GetalhiAakrgnveilklLl 55 
                    +++++el++l l +gad n +  r+           ++ l+  +k gn++ +k Ll
  EFC36051.1 135 IVLSKNNIELIKLFLKYGADSNTCQKRQahtmrydgssSFPFLYQSVKYGNLDLFKCLL 193
                 455699**************666522223333334333888999999999999999987 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.01
       Ank_4  10 isgrlelvrlLlekgad...............inaqdnrsGetalhiAak 44 
                 ++g+l+l + Lle++a+               i    ++  e +lh A+k
  EFC36051.1 182 KYGNLDLFKCLLEHNANtnlfafnrgsseygpI----DDLKELPLHLACK 227
                 489999999999999997777766666643322....455889***9993 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.4
       Ank_4  14 lelvrlLlekgadina 29 
                  e++ lL+ ++ din+
  EFC36051.1 270 KEMILLLIKYNSDINM 285
                 68999*********98 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       1.7   3.4e+03      59      78 ..      48      67 ..      40      72 .. 0.67
   2 !   19.6   0.1   5.2e-07     0.001      11      81 ..     102     201 ..      96     203 .. 0.75
   3 !   15.6   0.4   9.2e-06     0.018       7      62 ..     139     227 ..     133     244 .. 0.66
   4 ?    0.9   0.0      0.36   7.2e+02      65      81 ..     269     285 ..     260     292 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.7
       Ank_2 59 yAarsghleivklLl.ekgad 78
                 A+ +  ++ +klLl ekga+
  EFC36051.1 48 SAI-NRDFNRLKLLLiEKGAN 67
                455.55566677777677765 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 5.2e-07
       Ank_2  11 elvklLl.egadpn.....k......ngktaLhyAakngnleivklLleh..............adndgrtp...LhyAarsghleivklLlekgadin 80 
                 ++++lLl +ga++n     +         ta  +  +++n+e++kl+l++              +++dg +    L+ ++++g+l+++k Lle++a+ n
  EFC36051.1 102 QAIELLLsKGANVNaiygsSnwkgsgSSGTAFEIVLSKNNIELIKLFLKYgadsntcqkrqahtMRYDGSSSfpfLYQSVKYGNLDLFKCLLEHNANTN 200
                 47899999999998776651566767556*******************966555555555444422555543334*******************99988 PP

       Ank_2  81 l 81 
                 l
  EFC36051.1 201 L 201
                 7 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 9.2e-06
       Ank_2   7 ngnlelvklLl.egadpn.....k.........ngktaLhyAakngnleivklLleh..................adndgrtpLhyAar 62 
                 ++n el+kl+l +gad n     +              L+ ++k+gnl++ k Lleh                  +d+  + pLh+A++
  EFC36051.1 139 KNNIELIKLFLkYGADSNtcqkrQahtmrydgsSSFPFLYQSVKYGNLDLFKCLLEHnantnlfafnrgsseygpIDDLKELPLHLACK 227
                 35678999999888887665443145666655444556779999999999999999776655555444443333333558889999985 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.36
       Ank_2  65 hleivklLlekgadinl 81 
                 + e++ lL+++++din+
  EFC36051.1 269 YKEMILLLIKYNSDINM 285
                 56677777766677765 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0       0.3   5.9e+02      16      26 ..      55      67 ..      45      70 .. 0.74
   2 !    8.0   0.0    0.0021       4.2      16      29 ..     102     116 ..      87     117 .. 0.87
   3 ?    4.2   0.0     0.032        64      12      28 ..     139     156 ..     131     160 .. 0.83
   4 ?    2.8   0.0     0.094   1.9e+02      11      29 ..     182     201 ..     176     203 .. 0.86
   5 ?    4.7   2.3     0.022        45       5      28 ..     221     284 ..     220     287 .. 0.62

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.3
                HHHHHHH..TTTS CS
         Ank 16 riiklLL..hGAn 26
                + +klLL  +GAn
  EFC36051.1 55 NRLKLLLieKGAN 67
                5899988877998 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0021
                 HHHHHHH.TTTSTTC CS
         Ank  16 riiklLL.hGAnlna 29 
                 + i+lLL +GAn+na
  EFC36051.1 102 QAIELLLsKGANVNA 116
                 6799***88*****8 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.032
                 HTTHHHHHHHH.TTTSTT CS
         Ank  12 ngkkriiklLL.hGAnln 28 
                  ++ + ikl+L +GA+ n
  EFC36051.1 139 KNNIELIKLFLkYGADSN 156
                 567889*****88*9955 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.094
                 HHTTHHHHHHHH.TTTSTTC CS
         Ank  11 tngkkriiklLL.hGAnlna 29 
                  +g+++  k LL h An n+
  EFC36051.1 182 KYGNLDLFKCLLeHNANTNL 201
                 67999999*********995 PP

  == domain 5  score: 4.7 bits;  conditional E-value: 0.022
                 HHHHHH..............HHTT...........................HHHHHHHH.TTTSTT CS
         Ank   5 PLHlAa..............tngk...........................kriiklLL.hGAnln 28 
                 PLHlA+              +  +                           k++i lL+ + +++n
  EFC36051.1 221 PLHLACklfksinnininnnN--NinesydsddeynnnnnesksknnyekyKEMILLLIkYNSDIN 284
                 9****9888866666654330..1444444444444455666777777777888877776556776 PP

>> Peripla_BP_1  Periplasmic binding proteins and sugar binding domain of LacI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.5e-05     0.029     129     194 ..      66     127 ..      38     140 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.5e-05
                   -TTSHHHHHHHHHHHHHHHTT-GGGEEEEE-SSSSHHHHHHHHHHHHTT-TT-SEEE-SSHHHHHH CS
  Peripla_BP_1 129 esaltakervqGflaalaeaGlevkdvhvalgsndiedaaealnelleshPeidaivaindeaalG 194
                   ++a   ++r +G   a +e G    + +v+lg +d++++ +a++ ll+++ +++ai++ ++  + G
    EFC36051.1  66 ANAF-YNKRIEGVWGAYEEYGV---IHKVLLGWDDMKEQMQAIELLLSKGANVNAIYGSSNWKGSG 127
                   4444.467888***********...99******************************998766665 PP

>> Ribosomal_L6e  Ribosomal protein L6e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   3.1   0.00068       1.4      48      83 ..      12      48 ..       2      61 .. 0.79
   2 ?    6.0   0.3    0.0083        17      29     109 ..     219     302 ..     210     303 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00068
  Ribosomal_L6e 48 k.kkkeeelfeekkekkelseerkadqkavDkallaa 83
                   + +++eee  ee++e++e++ee ++ +k++D++ll++
     EFC36051.1 12 DqQQQEEEYNEEEEEEEEFNEEEEEIKKTLDDELLDS 48
                   23678999999999*******************9975 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0083
  Ribosomal_L6e  29 kipeklndeyFkkekkkkkkkkkeeelf.....eekkekkelseerkadqkavDkallaaikkekllkkYLkskFsLrkgdyphel 109
                    ++p +l  + Fk  ++ + +  +++++      +++ ++++ +++ k++ ++  + +l  ik ++ ++ Y k+ +++ +++yp ++
     EFC36051.1 219 ELPLHLACKLFKSINNININ--NNNNINesydsDDEYNNNNNESKSKNNYEKYKEMILLLIKYNSDINMYGKTVYQIPNENYPKNI 302
                    56666777777777555554..333333333445555557778888999999999***************************9886 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   4.9    0.0017       3.4      55      92 ..       9      45 ..       1      74 [. 0.52
   2 ?    2.9   0.0     0.038        76      65      90 ..     242     267 ..     217     296 .. 0.56

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0017
      FAM176 55 kkkkkklkeesekasededeeeeeeeedsseseaeeel 92
                + +++++ +e+e ++e+e+eee +eee++ +++ ++el
  EFC36051.1  9 QLNDQQQ-QEEEYNEEEEEEEEFNEEEEEIKKTLDDEL 45
                2222222.222222333334444444444444444544 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.038
      FAM176  65 sekasededeeeeeeeedsseseaee 90 
                 + ++s d+d+e ++++++s++++  e
  EFC36051.1 242 NINESYDSDDEYNNNNNESKSKNNYE 267
                 22234444444444444444333333 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   2.7      0.64   1.3e+03      34      57 ..      10      32 ..       2      52 .. 0.44
   2 ?   11.8   2.5   0.00012      0.23      13      68 ..     216     277 ..     211     284 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.64
       Orf78 34 aenkkekksaaeknditekesnaa 57
                 ++++++++ +++++ +e+e n +
  EFC36051.1 10 LNDQQQQEEEYNEEEEEEEEFN-E 32
                2222222233333333333333.1 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 0.00012
       Orf78  13 kvdyIPLKLAlndl......dnddndkaenkkekksaaeknditekesnaaekaqalnilli 68 
                  ++ +PL LA + +      + ++n++ +++ ++ + +++n+ ++k++n+ ek +++ +lli
  EFC36051.1 216 DLKELPLHLACKLFksinniNINNNNNINESYDSDDEYNNNNNESKSKNNYEKYKEMILLLI 277
                 56778999998755666655666666666666666677777777777776777777766666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2640  (0.147247); expected 358.6 (0.02)
Passed bias filter:                      834  (0.0465168); expected 358.6 (0.02)
Passed Vit filter:                       107  (0.00596798); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 2034.54
//
Query:       EFC36052.1  [L=177]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.024   15.3   5.3        1.4    9.6   0.5    2.6  2  FOXP-CC      FOXP coiled-coil domain
      0.028   14.4   0.1      0.052   13.5   0.1    1.4  1  PBECR3       phage-Barnase-EndoU-ColicinE5/D-RelE like nuclea
       0.13   12.6  12.4       0.41   11.0   0.4    3.4  3  zf-C2H2_jaz  Zinc-finger double-stranded RNA-binding
       0.94   10.1  16.3        2.2    8.9   4.0    3.7  3  zf-C2H2      Zinc finger, C2H2 type
        7.6    6.7  15.4       0.32   11.1   7.4    2.6  3  zf_ZIC       Zic proteins zinc finger domain


Domain annotation for each model (and alignments):
>> FOXP-CC  FOXP coiled-coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.6    0.0019       6.7      12      32 ..      63      83 ..      59      89 .. 0.91
   2 ?    9.6   0.5    0.0004       1.4      12      39 ..      90     117 ..      86     125 .. 0.91

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0019
     FOXP-CC 12 CekvledveeflkhlnseHal 32
                C+  + ++e++lkh+ +eH++
  EFC36052.1 63 CDYSCVKSETLLKHITKEHSI 83
                8999***************97 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0004
     FOXP-CC  12 CekvledveeflkhlnseHalddkstaq 39 
                 C+k+ +++ee++ h+n +H+++ ks+ +
  EFC36052.1  90 CDKHYTTMEEYVDHINFKHQTNTKSAIE 117
                 9**********************99865 PP

>> PBECR3  phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   1.4e-05     0.052      11      77 ..      54     116 ..      47     123 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.4e-05
      PBECR3  11 iakklgldlsgtkilidpgaikHilkrHgnqstekdrgqidianipdiiknPDkviyggknkkeksi 77 
                 +++klg  l +++ + +++++kHi k+H+ +  +  ++++ +  +++++++ +  +++++n k  +i
  EFC36052.1  54 TKEKLGCCLCDYSCVKSETLLKHITKEHSIKFPKVCCDKH-YTTMEEYVDHIN--FKHQTNTK-SAI 116
                 5788888888899999************777777777777.9***99999998..55555555.455 PP

>> zf-C2H2_jaz  Zinc-finger double-stranded RNA-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.2      0.35   1.3e+03       4      11 ..      17      24 ..      15      27 .. 0.81
   2 ?    7.2   1.6    0.0017       6.2       4      21 ..      60      77 ..      59      79 .. 0.96
   3 ?   11.0   0.4   0.00011      0.41       7      22 ..      90     105 ..      88     105 .. 0.96

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.35
                 BTTTTBBB CS
  zf-C2H2_jaz  4 CvlCdKyF 11
                 C  C+K  
   EFC36052.1 17 CDSCKKSL 24
                 999**976 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0017
                 BTTTTBBBSSHHHHHCCT CS
  zf-C2H2_jaz  4 CvlCdKyFksenaldnHl 21
                 C lCd  + ++++l +H+
   EFC36052.1 60 CCLCDYSCVKSETLLKHI 77
                 9****************9 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00011
                  TTBBBSSHHHHHCCTT CS
  zf-C2H2_jaz   7 CdKyFksenaldnHlk 22 
                  CdK++ +++ +  H++
   EFC36052.1  90 CDKHYTTMEEYVDHIN 105
                  **************98 PP

>> zf-C2H2  Zinc finger, C2H2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.4      0.29   1.1e+03       2       9 ..      16      23 ..      16      28 .. 0.85
   2 ?    8.9   4.0   0.00062       2.2       3      23 .]      60      81 ..      60      81 .. 0.96
   3 ?    7.4   0.3    0.0019       6.7       6      23 .]      90     108 ..      90     108 .. 0.94

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.29
                EETTTTEE CS
     zf-C2H2  2 kCpdCgks 9 
                +C+ C+ks
  EFC36052.1 16 RCDSCKKS 23
                79****98 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00062
                ETTTTEEESSHHHHHHHHHC.C CS
     zf-C2H2  3 CpdCgksFkrksnLkrHirt.H 23
                C  C++s+  ++ L +Hi + H
  EFC36052.1 60 CCLCDYSCVKSETLLKHITKeH 81
                999***************9988 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0019
                 TTEEESSHHHHHHHHHC.C CS
     zf-C2H2   6 CgksFkrksnLkrHirt.H 23 
                 C+k +++ ++++ Hi+  H
  EFC36052.1  90 CDKHYTTMEEYVDHINFkH 108
                 ***************9777 PP

>> zf_ZIC  Zic proteins zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.2       3.2   1.1e+04      23      30 ..      19      26 ..      14      28 .. 0.56
   2 ?    0.7   1.4      0.17     6e+02      33      42 ..      72      81 ..      43      83 .. 0.79
   3 ?   11.1   7.4   9.1e-05      0.32      10      42 ..      74     108 ..      66     109 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.2
                -----BSS CS
      zf_ZIC 23 pCsktFst 30
                +C+k   t
  EFC36052.1 19 SCKKSLHT 26
                46665544 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.17
                HHHHHHHCTT CS
      zf_ZIC 33 elVtHltveH 42
                 l  H+t eH
  EFC36052.1 72 TLLKHITKEH 81
                5889*****9 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 9.1e-05
                 --B--TT-..SSS-------BSSHHHHHHHHHCTT CS
      zf_ZIC  10 CkWideeq..gspkkpCsktFstmhelVtHltveH 42 
                  k i +e+  + pk  C+k+++tm e V H+   H
  EFC36052.1  74 LKHITKEHsiKFPKVCCDKHYTTMEEYVDHINFKH 108
                 5556555544568999***************9988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       976  (0.0544369); expected 358.6 (0.02)
Passed bias filter:                      225  (0.0125495); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 1050.53
//
Query:       EFC36053.1  [L=400]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.044   13.2   5.5       0.11   11.9   0.1    3.0  3  NMT1_3    NMT1-like family


Domain annotation for each model (and alignments):
>> NMT1_3  NMT1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.2     0.035   6.2e+02     190     218 ..      34      62 ..       9      79 .. 0.74
   2 ?   11.9   0.1   6.1e-06      0.11     169     231 ..     187     249 ..     147     254 .. 0.75
   3 ?    2.0   0.1    0.0062   1.1e+02     232     261 ..     336     365 ..     329     379 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.035
      NMT1_3 190 ddeqldkllkeypvftkyvipagtypqde 218
                 + +++++  k+y+++ +++i a+t++ ++
  EFC36053.1  34 SSKKRKAKSKAYEIVDSTTITATTPKSKK 62 
                 45566777889999999999999997644 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 6.1e-06
      NMT1_3 169 GvPvsavtqlaasedikliplddeqldkllkeypvftkyvipagtypqdedikTiavpnflvv 231
                       ++ + +++d ++ + ++++++++++++++ +   i ++t + ++d++Ti+++n  +v
  EFC36053.1 187 SETLNLIKLITNENDNNICNNNNNTIKSVVNNFEMDNYNDIVNNTKQTTNDVPTISQSNEGIV 249
                 555666777788899********************************************8776 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.0062
      NMT1_3 232 radldeelvYeitkaifenldelnsihkaa 261
                 ++  +eel+ ++ k + e+++++++++  +
  EFC36053.1 336 NERNNEELINDLMKQLNEKNQQIEQLNRMF 365
                 566789*****************9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (400 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3407  (0.190027); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 2368.17
//
Query:       EFC36054.1  [L=733]
Description: WD40 repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.9e-26   91.7  13.4      0.016   16.1   0.1   10.4 11  WD40         WD domain, G-beta repeat
    2.6e-10   40.4   0.0    4.7e-05   23.6   0.0    5.2  5  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    2.3e-08   33.8   0.0    4.6e-08   32.8   0.0    1.5  1  HELP         HELP motif


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.1   1.3e-05     0.077       2      38 .]      78     117 ..      77     117 .. 0.92
   2 ?    3.2   0.0      0.03   1.8e+02       3      32 ..     124     159 ..     122     164 .. 0.71
   3 !    7.0   0.0     0.002        12      12      38 .]     183     208 ..     172     208 .. 0.87
   4 ?    0.4   0.0      0.23   1.4e+03      15      37 ..     230     252 ..     217     253 .. 0.69
   5 !   12.0   0.0   5.1e-05       0.3       2      38 .]     256     298 ..     255     298 .. 0.88
   6 !   11.5   0.0   7.1e-05      0.43      13      38 .]     361     386 ..     347     386 .. 0.79
   7 ?    0.1   0.0      0.29   1.7e+03      14      36 ..     405     427 ..     395     428 .. 0.78
   8 !   14.1   0.0   1.1e-05     0.065      12      38 .]     450     477 ..     439     477 .. 0.83
   9 !   16.1   0.1   2.6e-06     0.016       3      38 .]     488     524 ..     486     524 .. 0.86
  10 ?   -3.5   0.0         3   1.8e+04      10      32 ..     563     583 ..     558     584 .. 0.68
  11 !    9.9   0.1   0.00023       1.4       5      38 .]     601     642 ..     599     642 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.3e-05
                 EEEEEEESS.SSEEEEEEETTSSEEEEE..ETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasG..sdDgtvriWd 38 
                 +++ +++ H ++v  +a +p+   +asG  ++D  ++iWd
  EFC36054.1  78 NTQSVFRKHdDDVVTIAKHPNEYIFASGqiGKDDMIYIWD 117
                 568899***87799**************999********9 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.03
                 EEEEEESS...SS..EEEEEEETTSSEEEE.EETTS CS
        WD40   3 clrtltGH...ss..vtslafspdgawlas.GsdDg 32 
                 ++++l++H   ++  v + +fs +g +l++ G+ D 
  EFC36054.1 124 PITKLDTHlhfKNggVLATSFSNSGELLVTvGGNDT 159
                 566677776552257988899******985377665 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.002
                 SEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  12 svtslafspdgawlasGsdDgtvriWd 38 
                  + +l+fspd + +  ++ ++ ++i++
  EFC36054.1 183 EIFDLQFSPDDSQIYICG-KKVLKIYN 208
                 389999********99**.******97 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.23
                 EEEEETTSSEEEEEETTSEEEEE CS
        WD40  15 slafspdgawlasGsdDgtvriW 37 
                 sl+f+  ++    G++Dg+++++
  EFC36054.1 230 SLCFNMKNQDAYVGCEDGSIYLF 252
                 5554444444456999****986 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 5.1e-05
                 EEEEEEESS.SSEEEEE..EETTSSE...EEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtsla..fspdgaw...lasGsdDgtvriWd 38 
                 +++ t+ GH ++v  l   +++++++   ++sG++Dg v+ W+
  EFC36054.1 256 KLINTINGHhGNVFTLYplYDKNSKFnygFISGGKDGQVKYWK 298
                 7788999**888****9998888888999889**********5 PP

  == domain 6  score: 11.5 bits;  conditional E-value: 7.1e-05
                 EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  13 vtslafspdgawlasGsdDgtvriWd 38 
                  ++l++ ++ ++++++sdDg v +W+
  EFC36054.1 361 LWGLDTFKELPLFVTCSDDGRVIVWN 386
                 788888889999*************8 PP

  == domain 7  score: 0.1 bits;  conditional E-value: 0.29
                 EEEEEETTSSEEEEEETTSEEEE CS
        WD40  14 tslafspdgawlasGsdDgtvri 36 
                 +++++sp++  +a  s+ g++ i
  EFC36054.1 405 RGVCVSPSNEHVAFTSKEGHLFI 427
                 68999******984577888877 PP

  == domain 8  score: 14.1 bits;  conditional E-value: 1.1e-05
                 S.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  12 s.vtslafspdgawlasGsdDgtvriWd 38 
                   +t l++++dg++la Gs D+ +++++
  EFC36054.1 450 EeITTLSYNHDGTLLAVGSHDNYIYLYN 477
                 259***************99*****997 PP

  == domain 9  score: 16.1 bits;  conditional E-value: 2.6e-06
                 EEEEEESS.SSEEEEEEETTSSEE.EEEETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawl.asGsdDgtvriWd 38 
                  +++l GH s++t+l+ s+ g++l + ++ D  + +Wd
  EFC36054.1 488 YIGKLIGHsSFITHLDISKCGNYLkSNSG-DYEILLWD 524
                 577899**777************856557.*******9 PP

  == domain 10  score: -3.5 bits;  conditional E-value: 3
                 SSSEEEEEEETTSSEEEEEETTS CS
        WD40  10 HssvtslafspdgawlasGsdDg 32 
                   +v+ + ++ ++ +++ G  D 
  EFC36054.1 563 T-DVNTCHVDYENELIIVGE-DT 583
                 4.687777788888887765.65 PP

  == domain 11  score: 9.9 bits;  conditional E-value: 0.00023
                 EEEESS.SSEEEEEEETTSSE.......EEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgaw.......lasGsdDgtvriWd 38 
                 +++ GH s+vt ++f +++         l++G+ D t+  W+
  EFC36054.1 601 YSYIGHcSHVTNVKFIHYNIEneritklLSCGGGDLTIFQWN 642
                 5799**888****744443337777775777777*******8 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.028   1.7e+02      38      89 ..     136     189 ..     126     192 .. 0.72
   2 !    5.2   0.0    0.0042        25      24      81 ..     201     266 ..     187     273 .. 0.73
   3 ?   -2.6   0.0       1.2   7.3e+03      56      79 ..     376     399 ..     371     404 .. 0.65
   4 !   23.6   0.0   7.8e-09   4.7e-05       4      67 ..     410     478 ..     407     483 .. 0.87
   5 ?    1.3   0.1     0.069   4.1e+02      38      83 ..     496     543 ..     490     553 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.028
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdg...evrlldaesgkvvhslsvksekavtclgW 89 
                  ++ v + +++++g+lL+ +  +     + l++ ++ +++ s ++ s++ +  l++
   EFC36054.1 136 NGGVLATSFSNSGELLVTVGGNDtssIILLYNWKKNELIASTKCLSSE-IFDLQF 189
                  556777899999**9987665541335667788888899998888874.666655 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0042
  ANAPC4_WD40  24 lngqrvwtl..........eedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                   +  +++++           ++++ ++ +sL+++++++   v+++dg++ l+   +gk++++++ ++ 
   EFC36054.1 201 KKVLKIYNTkdltfksgifGSKGTLQNLHSLCFNMKNQDAYVGCEDGSIYLF--RDGKLINTINGHHG 266
                  55555555566666666666677778899******************99887..58888888877665 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.2
  ANAPC4_WD40  56 aysdgevrlldaesgkvvhslsvk 79 
                    +dg+v + + e+ k  + l+ +
   EFC36054.1 376 CSDDGRVIVWNCENRKHASLLKLN 399
                  345678888888887777666655 PP

  == domain 4  score: 23.6 bits;  conditional E-value: 7.8e-09
  ANAPC4_WD40   4 cptmDLiAlatedgellvfRlngqrvwtl.....eedkedsevrsLaWkpdgklLavaysdgevrllda 67 
                  +p+++ +A+ +++g+l ++ +n ++   +     +++++++e++ L++++dg+lLav+ +d+ + l++ 
   EFC36054.1 410 SPSNEHVAFTSKEGHLFIYGFNLENYTFTeeplyTRKDSNEEITTLSYNHDGTLLAVGSHDNYIYLYNC 478
                  7999999**************9976433358888889***************************99985 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.069
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksek..a 83 
                  +s +++L  ++ g+ L     d e+ l d +s+k+ + +++++ +  +
   EFC36054.1 496 SSFITHLDISKCGNYLKSNSGDYEILLWDLNSKKLSNCSNIENIEwnS 543
                  5679999999**********************9998877766655442 PP

>> HELP  HELP motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.8   0.0   7.8e-12   4.6e-08      12      73 ..      15      74 ..       5      75 .. 0.87

  Alignments for each domain:
  == domain 1  score: 32.8 bits;  conditional E-value: 7.8e-12
        HELP 12 vtlyiPsklenldakkkselPdekLkLewvyGYrgkdcrnnlfll.ptgeivYfvAavvvlyn 73
                 + ++P+   n+++    +lP++kL+Le+++G   k c+   f + +++++vY  Aa +++y+
  EFC36054.1 15 AAHFPPT---NYEEMMVDKLPSKKLELEFIHGASKKGCKGCYFHInDENKLVYPSAACGIVYD 74
                4556776...799999***********************988877699**************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (733 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       421  (0.0234815); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 4540.58
//
Query:       EFC36055.1  [L=993]
Description: fumarate reductase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.2e-71  241.2   0.0    2.2e-71  241.2   0.0    1.6  2  FAD_binding_2   FAD binding domain
    2.7e-10   40.4   0.1    6.5e-10   39.1   0.1    1.7  1  DAO             FAD dependent oxidoreductase
    1.1e-06   28.8   0.9    3.1e-06   27.3   0.9    1.8  1  NAD_binding_8   NAD(P)-binding Rossmann-like domain
    4.9e-06   26.0   4.3    4.1e-05   22.9   4.3    2.4  1  Pyr_redox_2     Pyridine nucleotide-disulphide oxidoreductase
      1e-05   25.1   2.8      1e-05   25.1   2.8    2.6  2  FAD_oxidored    FAD dependent oxidoreductase
    5.9e-05   22.5   0.2    0.00016   21.0   0.2    1.7  1  AlaDh_PNT_C     Alanine dehydrogenase/PNT, C-terminal domain
    0.00027   20.2   1.5    0.00027   20.2   1.5    3.4  3  GIDA            Glucose inhibited division protein A
    0.00054   18.8   1.4    0.00054   18.8   1.4    3.7  4  HI0933_like     HI0933-like protein
    0.00072   18.9   0.5    0.00072   18.9   0.5    2.2  2  FAD_binding_3   FAD binding domain
     0.0012   19.3   2.6      0.005   17.4   1.1    2.8  2  Pyr_redox       Pyridine nucleotide-disulphide oxidoreductase
      0.003   16.8  23.8     0.0053   16.0  23.8    1.4  1  SOG2            RAM signalling pathway protein
  ------ inclusion threshold ------
       0.01   15.1   0.3       0.13   11.5   0.1    2.2  2  Thi4            Thi4 family
      0.014   15.7   0.1       0.05   14.0   0.1    1.9  1  Ribosomal_L18p  Ribosomal L18 of archaea, bacteria, mitoch. a
       0.32   10.9  18.8       0.21   11.5  16.3    1.8  2  TFIIA           Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> FAD_binding_2  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   1.1       2.1   2.7e+03     213     261 ..     372     419 ..     346     428 .. 0.75
   2 !  241.2   0.0   1.7e-74   2.2e-71       2     417 .]     483     967 ..     482     967 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.1
                    ..GSSSBSSGTT-S-HHHHHHHCTTSS.EES..TT-EEEEEEEET....T CS
  FAD_binding_2 213 aaaeaettnapavtGdglalalragaa.lnddrmeevqfhPtslvpirdg 261
                    aa     t+ p+vt +  +++  a+++  +  + e+ ++ Pts+ p  + 
     EFC36055.1 372 AATPSTPTTTPTVTAETKQVESKAKVEqQQ--QEEPTTTTPTSTTPTTTT 419
                    344445577889999999999999999444..5999999***99976555 PP

  == domain 2  score: 241.2 bits;  conditional E-value: 1.7e-74
                    EEEE--SHHHHHHHHHHHHTTT-EEEEESSSGGGSGGGG--S-EE-TT..SSGGSTC.CHHHHHHHHHHHHTTT-S-HHHHHHHHHTHHHHHHHHH CS
  FAD_binding_2   2 viViGsGlAGLaAAleaaeaGlkvavvekeqefggatawsqGgidavlspeqkkagikdspelhrtdtlkaldeladqplveafveaapeavdeLe 97 
                    v ViG+GlAGL+AA+e+ae G  v ++eke+++gg++a +  gi+ vl++ q+++ i d+++l + dt k++ + ++++l+ ++v+++  a+++Le
     EFC36055.1 483 VAVIGGGLAGLSAAIEIAELGGYVYLIEKEERTGGNSAKATSGINGVLTKAQERLSIPDTVDLFISDTTKSGKQAGNPKLISTLVKESTSAIEFLE 578
                    89********************************************************************************************** PP

                    HTT----BCCTSSB-EEE-TT-SSTEEEE-.STT-.......HHHHHHHHHHHHHHTCT...EEEEESEEEEEEEE...CTT..EEEEEEEEET.. CS
  FAD_binding_2  98 elgvpfsrtedgpvdvrelGglsatartlhdaadarr.etlvtghallarlvesarkag...vdfqerteadeLiv...edg..rvtGavvenp.. 182
                    ++g+ +         v+++Gg+s   rt+++a+ +   +++  g ++   l+++++++    v+++++t++  +++   e++   vtG+    +  
     EFC36055.1 579 NHGIGMEL-------VTQCGGHSMA-RTHRSAPPK-VgRAMNVGAEITFKLLNYIKNNLndrVTVMTSTKMIGFLTlidENNntIVTGIKYITLeq 665
                    ********.......**********.****66665.56*****************777689*********99888865444467777777666677 PP

                    .................TTTCEEEEEESEEEE-----GG.............GSSSBSSGTT-S-HHHHHHHCTTSS.EES..TT-EEEEEEEET. CS
  FAD_binding_2 183 .................esgrevrirakavvlatgGfgr...allkellgaaaeaettnapavtGdglalalragaa.lnddrmeevqfhPtslvp 257
                                     ++++  +++   vvl+tgG+ +     lke+++++ +  ttn + + G+g+++a+   +a l    me +q hPt+ ++
     EFC36055.1 666 eskeqskesqseqlkelKEQQVKELKVSSVVLTTGGYAAdreGYLKEYAPQLSKLPTTNGKFANGEGIRMAVKELGAsLIH--MESIQVHPTGFID 759
                    799999988888887777777779*****************999****************************988887999..************9 PP

                    ...TTTB...B--THHHHTT-EEE-TTSSBTHGGGS-HHHHHHHHH.HHHHTTTS.CCBEEEE-TT.............................. CS
  FAD_binding_2 258 irdgsgi...LitealrgeGgilvdkdGrrFmnelasrdvvsrailekeiaeggs.eanvyldash.............................. 319
                    + +++ +   L  ealr  Ggi+v+ +G+rF nel  rd vs+ i+++ ++e ++     y+++ +                              
     EFC36055.1 760 PLNPKSMtvfLAAEALRAYGGIIVNENGNRFCNELGRRDYVSDMIFKNCKSEIENgHTTAYMIMNDhvaksfsesllsfyigkgfikkfnnlqhah 855
                    99999999**************************************9987765556445566666569**************************** PP

                    ......SSHHHHHHHSHHHHHHHHHCCT......S-TTTS.....EEE.............EEEEEEEES-EEEBETTSBE.....STTEEESSBT CS
  FAD_binding_2 320 .....gldaegleatleaineeaangldkdfgrgidpadr.....pip......gpfyavkvvpaqhytmgGvetdengrv.....ldadgqpipG 394
                          l+ ++l +t+e++n+   + ++       ++ d        p       ++y  +++p+ hyt gG+  de++rv      d++ +pi+G
     EFC36055.1 856 qeslqHLNLQQLINTIENYNHFYNQ-YQ----LNNSIVDDfgknlF-PtlfnlnDTIYISRITPSIHYTHGGLLFDEKARVlrriaNDNTVEPIQG 945
                    **77777777777777776654444.33....22333333443540.244556679*************************999999999****** PP

                    EEE-STCEESSSSTTS--TTHHH CS
  FAD_binding_2 395 LYAaGevaaggvhganrlgGnsl 417
                    LY aGe+  gg+hg nrl+Gnsl
     EFC36055.1 946 LYTAGEAS-GGLHGLNRLAGNSL 967
                    ********.************98 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1   0.1     5e-13   6.5e-10       1      93 [.     482     665 ..     482     786 .. 0.72

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 5e-13
                 EEEEECTSHHHHHHHHHHHHTT..EEEEESSSSTTSSGGGSSEEEEESSSSTHHSTH.........................HHHHHHHHHHHHHHHHH CS
         DAO   1 dvviiGGGiiGlstAyeLarrg..VtllekgdiagsgaSgrnsgllhsglrylpeas.........................elarlslealeelrele 72 
                 +v++iGGG +Gls+A e a+ g  V l+ek+++ g g S +++  + + l +++e                            +  l++e+   ++ le
  EFC36055.1 482 KVAVIGGGLAGLSAAIEIAELGgyVYLIEKEERTG-GNSAKATSGINGVLTKAQE-RlsipdtvdlfisdttksgkqagnpkLISTLVKESTSAIEFLE 578
                 59*****************9977********9999.**********998854443.24789999999**************8888**********9999 PP

                 HHHSSTTS.EEEEEEEEEESS..................................................................H CS
         DAO  73 eelgidid.yrrtGllslaad..................................................................e 93 
                 ++ gi ++ + ++G  s+a++                                                                  +
  EFC36055.1 579 NH-GIGMElVTQCGGHSMARThrsappkvgramnvgaeitfkllnyiknnlndrvtvmtstkmigfltlidennntivtgikyitleQ 665
                 86.999998999*******974555555555555555555555555555555555555555555555555555544444444444431 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.9   2.4e-09   3.1e-06       1      40 [.     485     524 ..     485     537 .. 0.91

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 2.4e-09
                    EE--SHHHHHHHHHHHCCTEEEEEE-SSSSSSGGG-EECE CS
  NAD_binding_8   1 IvGaGlsGlvaAylLakagfdvlllekrdrlGGraasyev 40 
                    ++G+Gl+Gl+aA ++a+ g  v l+ek +r+GG++a ++ 
     EFC36055.1 485 VIGGGLAGLSAAIEIAELGGYVYLIEKEERTGGNSAKATS 524
                    8**********************************98876 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   4.3   3.2e-08   4.1e-05       2      58 ..     482     597 ..     481     725 .. 0.64

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 3.2e-08
                  SEEEE--SHHHHHHHHHHHHHTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHH.......................................... CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......................................... RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaqagakvtlvelegtclnggcllskallgvaedaeias.......................................... 57 
                  +v+viGgG AGl+aa+++a+ g+ v+l+e+e+ + ++    ++ + gv  +a++++                                          
   EFC36055.1 482 KVAVIGGGLAGLSAAIEIAELGGYVYLIEKEERTGGNSAKATSGINGVLTKAQERLsipdtvdlfisdttksgkqagnpklistlvkestsaieflen 579
                  79**************************9666666666666666666666666555666688888888888888888888888555555555555555 PP

                  .................H CS
                  .................x RF
  Pyr_redox_2  58 .................e 58 
                                   +
   EFC36055.1 580 hgigmelvtqcgghsmaR 597
                  555555555555555550 PP

>> FAD_oxidored  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.7   6.7       8.6   1.1e+04     184     259 ..     385     460 ..     345     477 .. 0.50
   2 !   25.1   2.8     8e-09     1e-05       2      43 ..     483     524 ..     482     676 .. 0.80

  Alignments for each domain:
  == domain 1  score: -4.7 bits;  conditional E-value: 8.6
  FAD_oxidored 184 geedekvqaynkrl.cltskpenrvpfekkpegydparyel..arvfeaklskgklpgektdvnwprvstdlienldlp 259
                    +e+++v++  k   + +++p ++ p++++p   +++++e    ++ ++  +  ++++++t +n p  s+d   + + +
    EFC36055.1 385 TAETKQVESKAKVEqQQQEEPTTTTPTSTTPTTTTKQQQEEvtTPITTT-PTSDQKQSDTTTTNQP--SMDTPTVEQST 460
                   3334444433322203333335555555566666666666554444444.5666666667888887..55554222222 PP

  == domain 2  score: 25.1 bits;  conditional E-value: 8e-09
  FAD_oxidored   2 vvVvGGgpaGvaAAiaAaraGakvlLveergvlGGlltsglv 43 
                   v V+GGg+aG+ AAi  a+ G  v L+e++++ GG+++++  
    EFC36055.1 483 VAVIGGGLAGLSAAIEIAELGGYVYLIEKEERTGGNSAKATS 524
                   89**********************************876654 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.2   1.2e-07   0.00016      23     111 ..     475     564 ..     457     570 .. 0.71

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.2e-07
                  ETCB---EEEEESTSHHHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTTTCECEEHCHHHHHHHHHHHH-SEEEE---BTTSS-..--SC- CS
  AlaDh_PNT_C  23 vpgvepakvlviGgGvaGlqAiatakglgakVtvlDvrparleqleslgakfvevlksqeellaeavkeadvvigtvlipGkka..PkLvt 111
                   +  +p kv viGgG aGl+A+   ++lg  V+++++++++  +  +  + +  vl++ +e   +   ++d+ i+     Gk+a  PkL++
   EFC36055.1 475 QSSSSPIKVAVIGGGLAGLSAAIEIAELGGYVYLIEKEERTGGNSAKATSGINGVLTKAQER-LSIPDTVDLFISDTTKSGKQAgnPKLIS 564
                  4445699******************************9999888777555523333333333.3445667888887777777765577776 PP

>> GIDA  Glucose inhibited division protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   1.5   2.1e-07   0.00027       1      32 [.     482     513 ..     482     532 .. 0.84
   2 ?    2.1   0.1     0.066        84     111     153 ..     661     704 ..     645     746 .. 0.78
   3 ?   -3.9   0.0       4.2   5.3e+03     353     367 ..     941     955 ..     934     959 .. 0.82

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 2.1e-07
                 CEEEE-SSHHHHHHHHHHHHTT--EEEEES-G CS
        GIDA   1 dviViGgGhAGceAAlaaarlGakvlLithkl 32 
                 +v ViGgG+AG+ AA+++a+lG  v Li ++ 
  EFC36055.1 482 KVAVIGGGLAGLSAAIEIAELGGYVYLIEKEE 513
                 699************************95443 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.066
                 EEEEES-EEEEEECT.TEEEEEEETTS-EEEECEEEE--TT-BT CS
        GIDA 111 leiieeeveelivee.kkvkgvvtedgetikakavviatGtflk 153
                 +++ +e+ e+ + ++ +++k ++ ++ +++k ++vv++tG + +
  EFC36055.1 661 ITLEQESKEQSKESQsEQLKELKEQQVKELKVSSVVLTTGGYAA 704
                 5666555555433335888999999999999*********9865 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 4.2
                 SSSBTEEE-CGGGTB CS
        GIDA 353 kkvkgLflAGqinGt 367
                 + ++gL++AG+ +G 
  EFC36055.1 941 EPIQGLYTAGEASGG 955
                 5689*******9985 PP

>> HI0933_like  HI0933-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   4.2       4.6   5.9e+03      47     146 ..     256     361 ..     254     381 .. 0.62
   2 !   18.8   1.4   4.2e-07   0.00054       2      36 ..     482     516 ..     481     526 .. 0.93
   3 ?    3.6   0.1     0.017        22     125     169 ..     662     706 ..     651     720 .. 0.79
   4 ?   -3.9   0.1       3.3   4.3e+03     298     338 ..     828     872 ..     806     878 .. 0.47

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 4.6
                  -EEEETT-S.GGGEEES...STTTTHHHHHHS-HHH..HHHHHHH..TT--EEE-STTEEEETT..-CHHHHHHHHHHHHHHT-EEE-S--EEEEECE CS
  HI0933_like  47 cNvTnlsee.peellsrypenpkflksalsrftned..lialvee..lgvelkeedsgrlFpvsd.kaedivdallkelkeagvklrletevksveke 138
                  cN+ nl+e+  + + +++++n  +l + ++ f n d  +i+  ++  +++ l+  d+ +++++ + + e+ +++++++++++++     t+ ++ +++
   EFC36055.1 256 CNLNNLNENdNNSIHNSINQNTITLFEEFNYFYNYDdnIIDSNNNnlNNILLNNSDRIKIYTNLNsEFEQALEFIQNKIHKKQIPNLNPTTTTTSTTQ 353
                  99999665505556677888888888889888775433666655422466677777777787653145678888888888877765555555544444 PP

                  TTE.EEEE CS
  HI0933_like 139 edgkfrvk 146
                   + + + +
   EFC36055.1 354 PSTSTTTT 361
                  44434444 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 4.2e-07
                  SEEEE--SHHHHHHHHHHHHTT--EEEE-SSSSS- CS
  HI0933_like   2 dviviGgGaAGlmaAisaakrgkrVlllekakklg 36 
                  +v+viGgG AGl aAi++a+ g  V l+ek++++g
   EFC36055.1 482 KVAVIGGGLAGLSAAIEIAELGGYVYLIEKEERTG 516
                  79*****************************9987 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.017
                  EEE-S--EEEEECETTE.EEEEE.TTEEEEESEEEE----SS-GG CS
  HI0933_like 125 klrletevksvekeedgkfrvktkseeeleadklvlAtGGlSiPk 169
                  +l+ e++ +s e+++++  ++k ++ +el+ +++vl+tGG ++ +
   EFC36055.1 662 TLEQESKEQSKESQSEQLKELKEQQVKELKVSSVVLTTGGYAADR 706
                  555666666666777777788888999*************98766 PP

  == domain 4  score: -3.9 bits;  conditional E-value: 3.3
                  TTTS-HHHHHHHHHC..TTT....-TTBGGG--HHHHHHHHHHHH CS
  HI0933_like 298 aellpkrlvevlleealiee....edkklaqlskkelkklaealk 338
                  a+ + + l+ +++ +  i++    ++++ ++l++ +l++l+++++
   EFC36055.1 828 AKSFSESLLSFYIGKGFIKKfnnlQHAHQESLQHLNLQQLINTIE 872
                  444444444444444333210000223333444444444544444 PP

>> FAD_binding_3  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.6   4.7       7.9     1e+04      93     143 ..     379     431 ..     313     448 .. 0.52
   2 !   18.9   0.5   5.6e-07   0.00072       3      40 ..     482     519 ..     480     527 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.6 bits;  conditional E-value: 7.9
                    HHCST-CEE--HHHHHHHHHHHHHHHT.EEETCSEE.EECCEECCCCCCCEEE CS
  FAD_binding_3  93 esspervtvypqteleriLvehaeerg.lqvrfkte.vesleqdeegvtaevr 143
                     ++p+ ++   q e +  ++++ +e++ +++  +t  +++ +q++e+vt+ ++
     EFC36055.1 379 TTTPTVTAETKQVESKAKVEQQQQEEPtTTTPTSTTpTTTTKQQQEEVTTPIT 431
                    23333333444444444455555555543333333235555555555555444 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 5.6e-07
                    EEEEE--SHHHHHHHHHHHHTTHHEEEEESSSSSCCSS CS
  FAD_binding_3   3 dVlIVGaGpaGlmlallLseaGvrvvlvekrsttvvlp 40 
                    +V+++G+G+aGl++a + +e G  v l+ek ++t  ++
     EFC36055.1 482 KVAVIGGGLAGLSAAIEIAELGGYVYLIEKEERTGGNS 519
                    79*****************************9987766 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   1.1   3.9e-06     0.005       1      35 [.     482     516 ..     482     530 .. 0.92
   2 ?   -1.0   0.0       2.1   2.7e+03      19      41 ..     626     650 ..     612     669 .. 0.73

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 3.9e-06
                 EEEEECSSHHHHHHHHHHHHTTSEEEEEESSSSSS CS
   Pyr_redox   1 kvvvvGgGyiglElAgalaelgkkVtvversdkll 35 
                 kv+v+GgG+ gl +A ++aelg  V+++e +++  
  EFC36055.1 482 KVAVIGGGLAGLSAAIEIAELGGYVYLIEKEERTG 516
                 79***************************998865 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.1
                 HHTTSEEEEEESSSSSS..TTSSHH CS
   Pyr_redox  19 aelgkkVtvversdkll..rllDee 41 
                 ++l+++Vtv+   +++    l+De 
  EFC36055.1 626 NNLNDRVTVMTSTKMIGflTLIDEN 650
                 5688899998888877755555554 PP

>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0  23.8   4.1e-06    0.0053     144     317 ..     322     481 ..     319     618 .. 0.62

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 4.1e-06
        SOG2 144 Evrnawksiapeleavqplkptaskkkragrtksksisttssgssstlvssaesstesrassvt.ytartRhagsfsaqdveqGaaltplrsd.qipfn 240
                 E   a ++i+++ +++q   p++++++++++t ++s+stt+ + ++  ++++++ t+s++ +++  ta+t    + s+ +veq ++ +p ++  + +  
  EFC36055.1 322 EFEQALEFIQNKIHKKQI--PNLNPTTTTTSTTQPSTSTTTTT-PQAETTTTTAATPSTPTTTPtVTAETK--QVESKAKVEQQQQEEPTTTTpTSTT- 414
                 667889999999988888..88899999999999999888844.444666666666666666653455544..3444445555555554222222222. PP

        SOG2 241 lsrsrrssssgnsaspaangaqsetsersasssgvqssasstPlgegstsppgalsrqslsttgststltsssksrs 317
                   ++ +++++++ ++p  ++++s+++++ +++  ++++++ tP  e+st++       s++tt+stst+++ss+s  
  EFC36055.1 415 -PTTTTKQQQEEVTTPITTTPTSDQKQSDTTT--TNQPSMDTPTVEQSTTQ-------STTTTESTSTTNQSSSSPI 481
                 .3334444444556666665544444433332..44444555555555544.......3334444444444444333 PP

>> Thi4  Thi4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1    0.0001      0.13      19      59 ..     482     521 ..     466     570 .. 0.85
   2 ?    1.0   0.0      0.16     2e+02     206     231 ..     937     962 ..     926     965 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.0001
                 EEEEE--SHHHHHHHHHHHHCTTS-EEEEESSSS--TTTTT CS
        Thi4  19 DvvivGaGssGLtaayylakkpdlkvailersvspGGGawl 59 
                  v+++G+G +GL+aa  +a+  +  v ++e++   GG +  
  EFC36055.1 482 KVAVIGGGLAGLSAAIEIAEL-GGYVYLIEKEERTGGNSAK 521
                 699*****************9.889******9999997765 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.16
                 HHECEEETTEEE-THHHHHHHT-EB- CS
        Thi4 206 kktrevvpnlyvaGmevaevdganRm 231
                  +t e +++ly aG ++  ++g+nR+
  EFC36055.1 937 DNTVEPIQGLYTAGEASGGLHGLNRL 962
                 5899999******************7 PP

>> Ribosomal_L18p  Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.1   3.9e-05      0.05      24      97 ..     629     703 ..     618     715 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.9e-05
                     S-EEEEEE-SS-E.EEEEE-TTT--EEEEECS-SCCCTS-SSSCHHHHHHHHHHHHHHHCHHCHTC-EE--TTSS CS
  Ribosomal_L18p  24 rprlvvfrsnrhi.yaQviddvkgktlasastlekelklkstknkeaakkvgeliAerakekgiekvvfDrggyk 97 
                       r++v+ s++ i +  +id++++++++ +  +  e + k+++++++++++ el  ++ ke ++++vv  +ggy 
      EFC36055.1 629 NDRVTVMTSTKMIgFLTLIDENNNTIVTGIKYITLEQESKEQSKESQSEQLKELKEQQVKELKVSSVVLTTGGYA 703
                     569999999999967899*******99999988888888899******************************985 PP

>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  16.3   0.00017      0.21     168     296 ..     332     469 ..     257     574 .. 0.46
   2 ?   -1.0   0.0       1.1   1.4e+03     268     282 ..     668     682 ..     583     721 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00017
       TFIIA 168 gsaaqssvaalqaq.sqqaqalaepqqq.lekq...................qqq.qqqqqqqqqqq.qvqqqqqe...............esqqaqqa 228
                 ++++++++++l+++ +  ++++++p++   +                     + + ++ +++q +++ +v+qqqqe               ++qq++  
  EFC36055.1 332 NKIHKKQIPNLNPTtT--TTSTTQPSTStTT-TtpqaetttttaatpstpttT-PtVTAETKQVESKaKVEQQQQEepttttptsttptttTKQQQE-- 424
                 1222222222221110..1111111111000.001111111111111111110.0011111111111111111111111111111100000000000.. PP

       TFIIA 229 sqeqvag.sqvessqtdgaedaleeespv..legelsaeeeagaqkeelsreeidrireealkakelekes 296
                   e++++ + +  s +++++  +++++++                           + e++++++ ++ es
  EFC36055.1 425 --EVTTPiTTTPTSDQKQSDTTTTNQPSMdtP-----------------------TV-EQSTTQSTTTTES 469
                 ..011111111111111111111111111110.......................11.0111111111111 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.1
       TFIIA 268 gaqkeelsreeidri 282
                 ++q++e+++e+++++
  EFC36055.1 668 KEQSKESQSEQLKEL 682
                 111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (993 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2773  (0.154666); expected 358.6 (0.02)
Passed bias filter:                      589  (0.0328518); expected 358.6 (0.02)
Passed Vit filter:                       158  (0.00881254); expected 17.9 (0.001)
Passed Fwd filter:                        47  (0.00262145); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 1.43u 0.38s 00:00:01.81 Elapsed: 00:00:00.61
# Mc/sec: 4884.02
//
Query:       EFC36056.1  [L=496]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.9e-66  222.5   0.0    1.1e-65  221.7   0.0    1.4  1  Pkinase      Protein kinase domain
    5.3e-24   84.9   0.0    7.8e-24   84.3   0.0    1.3  1  Pkinase_Tyr  Protein tyrosine kinase
    1.2e-07   31.4   0.0    5.9e-05   22.5   0.0    2.3  2  Kinase-like  Kinase-like
  ------ inclusion threshold ------
      0.052   13.2   0.6       0.83    9.2   0.0    2.6  3  FTA2         Kinetochore Sim4 complex subunit FTA2
      0.065   13.1   0.0        0.1   12.5   0.0    1.3  1  APH          Phosphotransferase enzyme family
        5.4    4.0  14.6        6.9    3.6  14.6    1.0  1  GREB1        Gene regulated by oestrogen in breast cancer
        6.4    5.2  19.5        8.5    4.8  19.5    1.1  1  Macoilin     Macoilin family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  221.7   0.0   4.2e-69   1.1e-65       1     264 []     143     452 ..     143     452 .. 0.90

  Alignments for each domain:
  == domain 1  score: 221.7 bits;  conditional E-value: 4.2e-69
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.......SSEEEEEEE--TTEBHHHHHH.. CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.......kdelylvleyveggeladlle.. 90 
                 y+ ++ +G+GsfG+V+ a+ +etg+ivA+Kk+ ++k+ k+      rE++++k+l+hpn+v+l+++f++       + +l lvleyv+ + +   ++  
  EFC36056.1 143 YSAVKVIGNGSFGVVFLAKVQETGDIVAIKKVLQDKRFKN------RELQVMKTLSHPNVVELKNYFYSrgdrdpeEVYLNLVLEYVPDTVYRFCMNya 235
                 667899****************************999883......69*********************9****7777777*******88844444455 PP

                 .HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHH CS
     Pkinase  91 .rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtseYlAPEvl.keneyskkvDvWslGvi 186
                  +++ +++  +k ++ q+l+++ y+Hs gi+HrD+Kp+N+Lid  +g lK++DFG ak+l+++++  s++++++Y+APE++ ++++y+ +vDvWs+G++
  EFC36056.1 236 kHNSYVPSIYVKLFVFQLLRSVIYIHSLGICHRDIKPQNLLIDpVSGILKLCDFGNAKQLKEGEPNVSYICSRYYRAPELIfQSTKYTCSVDVWSCGCV 334
                 377779*************************************88999*************************************************** PP

                 HHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHHTTS..............................................-H CS
     Pkinase 187 lyelltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasei..............................................se 235
                 + el+ g+p+f+   g++     +dql++i+k+lg    +   ++   ++                                                +
  EFC36056.1 335 MGELMLGTPLFQ---GES----SVDQLVEIIKVLGapskQ---DILAMNKNytefkfpqvkpnpwdqvfadrfqflqrnyqanngsnsgsqidpfieMN 423
                 ************...544....8999999*****986431...33222222356788888899**********************************99 PP

                 HHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 236 eakdllkkllkkdpkkRltaeellqhpyl 264
                 +  dl++kll++dpk+R+t +++l+hp++
  EFC36056.1 424 NSVDLITKLLQYDPKRRITPMDALAHPFF 452
                 99**************************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.3   0.0     3e-27   7.8e-24       4     207 ..     146     346 ..     143     399 .. 0.82

  Alignments for each domain:
  == domain 1  score: 84.3 bits;  conditional E-value: 3e-27
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE...SSSS......EEEEEE--TTEBHHHHH CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct...keep......llivteyvkgGdLlkfL 92 
                   k +G+G+fG V+ ++++    ++   Va+K++ ++++ +      +e+++mk+l+hpn+v+l    +   +  +      l +v+eyv+    +  +
   EFC36056.1 146 VKVIGNGSFGVVFLAKVQ----ETGDIVAIKKVLQDKRFK-----NRELQVMKTLSHPNVVELKNYFYsrgD--RdpeevyLNLVLEYVPDTVYRFCM 232
                  689***************....88899*****96666655.....57******************9996652..1346666899******99888888 PP

                  HHTCTTTSBHHHHHH.HHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.EEHHHH CS
  Pkinase_Tyr  93 rkkekekltlkdlls.falqvAkGmeyLeskklvHrdlaarNvLlse.nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.ftsksD 187
                  +  ++++   +  ++ f++q+ + + y++s  + Hrd+  +N L++  + + k++DfG a+++   +e + + +  ++  + apE +++++ +t + D
   EFC36056.1 233 NYAKHNSYVPSIYVKlFVFQLLRSVIYIHSLGICHRDIKPQNLLIDPvSGILKLCDFGNAKQL---KEGEPNVSYICSRYYRAPELIFQSTkYTCSVD 327
                  8775555555555543899***************************8477*************...4445556667777888****988755****** PP

                  HHHHHHHHHHHHTTSSGTTT CS
  Pkinase_Tyr 188 vWsfGvllwEiftlgespyp 207
                  vWs G ++ E++  g   ++
   EFC36056.1 328 VWSCGCVMGELML-GTPLFQ 346
                  ***********97.554444 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.1     0.002       5.1      16      60 ..     145     189 ..     136     193 .. 0.87
   2 !   22.5   0.0   2.3e-08   5.9e-05     150     239 ..     250     334 ..     232     339 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.002
  Kinase-like  16 rgellkkgdrsvvfevkdqetgeplavkvfllpseaskkdlerlk 60 
                   ++++++g ++vvf++k qetg+ +a+k  l  ++  +++l+ +k
   EFC36056.1 145 AVKVIGNGSFGVVFLAKVQETGDIVAIKKVLQDKRFKNRELQVMK 189
                  5789************************99988877777777665 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 2.3e-08
  Kinase-like 150 TlqlirlaanLqakglvhgkftvdnlllde.kgglmlggftaLvragtkvvl.seve.kgfaPpEllgsrggytrknktkmthkldaWqlGlv 239
                    ql+r + +++++g+ h +++++nll d+  g l+l +f++  + ++  +  s ++ + +  pEl+ +         tk+t ++d+W  G v
   EFC36056.1 250 VFQLLRSVIYIHSLGICHRDIKPQNLLIDPvSGILKLCDFGNAKQLKEGEPNvSYICsRYYRAPELIFQ--------STKYTCSVDVWSCGCV 334
                  479**************************9446689****9988777666644888878999****987........689**********987 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.83   2.1e+03     134     163 ..      70     104 ..      33     129 .. 0.54
   2 ?    0.9   0.0      0.11   2.9e+02      24      82 ..     143     203 ..     131     207 .. 0.73
   3 ?    9.2   0.0   0.00032      0.83     180     214 ..     252     292 ..     241     293 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.83
        FTA2 134 nsfakete.....drsralgeedgkkrpiraIVKe 163
                 n+++++t+     + +r++++ ++k++p + +V  
  EFC36056.1  70 NNTNNITNqpgneSPTRKTKSINSKQQPSTSLVNS 104
                 22222221233343344445555566666666666 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.11
        FTA2  24 iefleyLgkglhsiVlkvkirgk..eYALKlFrfleaeele..eaeedlkiprealkelasys 82 
                 +  ++++g+g  ++V+ +k+++   + A+K  + l+++  +  e + +++ ++ ++ el++y+
  EFC36056.1 143 YSAVKVIGNGSFGVVFLAKVQETgdIVAIK--KVLQDKRFKnrELQVMKTLSHPNVVELKNYF 203
                 55688999*****99999998766699999..4443333334577778888888888888887 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00032
        FTA2 180 kllrdlkklhklgIvvrDlkeenyidg......kLvDlsaa 214
                 +llr +  +h+lgI +rD+k++n++ +      kL+D+++a
  EFC36056.1 252 QLLRSVIYIHSLGICHRDIKPQNLLIDpvsgilKLCDFGNA 292
                 7899*******************974323335577888765 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   4.1e-05       0.1     166     189 ..     263     282 ..     249     293 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.1e-05
                 EEEE-SS-SGGGEEEC..TTEEEE CS
         APH 166 tvllHgDlhpgNllvdpddgrvtG 189
                  +++H+D++p+Nll+d    +v+G
  EFC36056.1 263 LGICHRDIKPQNLLID----PVSG 282
                 689*************....3334 PP

>> GREB1  Gene regulated by oestrogen in breast cancer
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6  14.6    0.0027       6.9    1139    1254 ..      15     139 ..       2     180 .. 0.40

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0027
       GREB1 1139 ssktspvkvekseskd.avesglsskasakselse.......asaaaasaseeakspkasvtseeeeseeskekekeslsketesqlsleaseqkea 1227
                  +++ s+++++++++ d  +++    +  ++ ++++       +s+++++++++++++++++t++  + + + + ++ + +++ +++l +++ +q+++
  EFC36056.1   15 NNSNSNTNTTNNNNMDnLINNFNYLQIGNNDKTNRsynnyqsSSKSTTTSTTTTTNNTNNITNQPGNESPTRKTKSINSKQQPSTSLVNSSIQQQQQ 111 
                  2222222222211111011111111111111111100111111222333333333333334444444433333333334444444444444444444 PP

       GREB1 1228 ldakasskssssssssssass.Pssscs 1254
                  +++++s++++++++ ++s++s P+++ +
  EFC36056.1  112 PNNNSSTTTTTTTAAATSTTSpPTRQGK 139 
                  4444433333333333333332444333 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8  19.5    0.0033       8.5     257     423 ..      12     186 ..       2     203 .. 0.44

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0033
    Macoilin 257 ekkksakssrsdskkkhehn........esvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskkasagsagssnsssk 347
                 +++++++s+++ +++++ +n        +  ++++++ +y + +s+sk   ++++++++++++   +   ++s++ ++++ nsk++ +  ++ +nss +
  EFC36056.1  12 NNNNNSNSNTNTTNNNNMDNlinnfnylQIGNNDKTNRSYNNYQSSSKST-TTSTTTTTNNTNNITNQPGNESPTRKTKSINSKQQPS--TSLVNSSIQ 107
                 22222222211111111111333333322222233333332222222222.2222222222222222222333333333333333333..333344433 PP

    Macoilin 348 khs..essksvtsssssknskkqklpaGkssaalkdaaenslpnnqlskk.dalvrLeadikkLkaeLqasrqteqelr 423
                 +++  ++++s+t++++++       p  ++++    +a +++ n++ +    a v+  +di  +k  Lq +r +++el+
  EFC36056.1 108 QQQqpNNNSSTTTTTTTAAATSTTSPPTRQGKVVSYSAVKVIGNGSFGVVfLAKVQETGDIVAIKKVLQDKRFKNRELQ 186
                 3320134444444445555555555666666766677777888888765414566777899999999999998888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2277  (0.127001); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                       102  (0.00568911); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.92u 0.36s 00:00:01.28 Elapsed: 00:00:00.54
# Mc/sec: 2741.68
//
Query:       EFC36057.1  [L=552]
Description: long-chain-fatty-acid--CoA ligase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-92  309.0   0.0    4.8e-92  308.8   0.0    1.1  1  AMP-binding    AMP-binding enzyme
    1.9e-15   57.6   0.1    3.5e-15   56.7   0.1    1.5  1  AMP-binding_C  AMP-binding enzyme C-terminal domain


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  308.8   0.0   5.4e-96   4.8e-92       3     422 ..      26     450 ..      24     451 .. 0.90

  Alignments for each domain:
  == domain 1  score: 308.8 bits;  conditional E-value: 5.4e-96
                  HHHHHSTTSEEEEE......CCSTEEEEHHHHHHHHHHHHHHHH.HTTSSTT-EEEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHH CS
  AMP-binding   3 eqaaktpdkvalvd......sgegqtlTYreldervnrlAagLr.slGvkkgdrVaillpnspewvvallailkaGavvvplnptltaeelayileds 93 
                  e+++++ d +a++d      +  + tlTY+++ ++   +++ L  + ++kkg+++a++lpn p +  ++++i + G+++ +lnp ++ ee+  +l+ds
   EFC36057.1  26 EKCREHGDNIAMIDgtspdpNLPNCTLTYNQMADNMLTIGNNLIdQFNIKKGNVIAMILPNIPLFPCIFHGIGYTGGIITTLNPLYSVEEINNQLKDS 123
                  5789999**********9998899********************99**************************************************** PP

                  TESEEEETCTCCC.HHHHHHHHSCC-EECEEEEESCCS-HCCHCCCHCCCCSCTTS.............-TSCCCS-BTTSEEEEEEE--SSSS-EEE CS
  AMP-binding  94 eakvliatvdsel.leklleaaakleavklvivldadellkeeelkeeeeseekae.............kpeeeeelkpddlayiiYTSGTTGkPKGV 177
                  +a +++  + ++   + +l+++++   vk + vl  +++++ ++l +e++     +             + ++ + +  +dl+ + Y+SGTTG  KGV
   EFC36057.1 124 NACMMF--TLQTFlEKTILACKGT--NVKNIFVLNYQPSDQFNNLLNENDLI---KlidakillakqnvEMRKIDINPLEDLIALPYSSGTTGLSKGV 214
                  ******..7777878899999985..46666666655555554444444333...123467888999985556666788******************* PP

                  EEEHHHHHHHHHHHHHHHCSCCTTT-EEEESS-TTSCHHHHHHHHHHHHTT-EEEE-TTCGCCHHHHHHHHHHHHT-SEEEEEHHHHHHHHHCCCHHC CS
  AMP-binding 178 mlshrnlvanvaslkletrfklkeddvvlsilplahifglilelllallsGatvvllpkdaaldpklllelieklkvtviagvPrvleallesgalka 275
                   l+h nl++nv ++   +++kl+++dv+++ lp++hi+g+++ ++lal+ G++ + + +++    +++l+ +++++vt ++++P ++ al++++ ++ 
   EFC36057.1 215 CLTHYNLISNVLQI-GAKYEKLTKNDVIVALLPFFHIYGMTVLCNLALYEGSKAITMARFDL---ETFLKIVQNYQVTRTHLAPPIILALAKHPIID- 307
                  *************9.466788999**********************************9988...4579************************9998. PP

                  HHHHCCGTT-SEEEEESS-EBHHHHHHHHHHHTCEEEEEEEEGGGSSECEECHCTTTCTSTTS-BEE-TTEEEEEE-TTTSCBE.ETTSEEEEEEEET CS
  AMP-binding 276 akkakdlsslrlvllggeplspellrffralfgeevlegYGlTEttgvvtvlpleedkkklgsvGkplpgvevkivDeetgepv.pdgeeGellvrgp 372
                     +++l s++++l+g++pls+++ + +++++g  v +gYG+TE ++vv+v+ +  d  k gs G  + ++++ki+D etg+++ + g++Gel+++gp
   EFC36057.1 308 ---KYNLTSMKYCLSGAAPLSSDVSQLLSNRLGVIVKQGYGMTESSPVVSVCGDTSDLIKDGSSGLLVNNTKLKIIDTETGNEItEYGQVGELCFSGP 402
                  ...569*******************************************776777888899********************9995699********** PP

                  TS-SEBTT-HHHHHHHEEETCCEEEEEEEEEEETTSEEEEEEECCCEEEE CS
  AMP-binding 373 gvmkgYlkkpeataeafdsegrwlrTGDlgrldedGyleivgRkkdlikl 422
                  ++mkgYl++++at+++++  +++l+TGDlg++d+dG ++iv+R+k+lik 
   EFC36057.1 403 QIMKGYLNNEQATKSTLI--DGYLHTGDLGYIDQDGFIFIVDRLKELIKY 450
                  *****************9..57**************************97 PP

>> AMP-binding_C  AMP-binding enzyme C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.7   0.1     4e-19   3.5e-15       2      76 .]     460     534 ..     459     534 .. 0.94

  Alignments for each domain:
  == domain 1  score: 56.7 bits;  conditional E-value: 4e-19
                    HHHHHHSSTTEEEEEEE-----TTS---EEEEEE------.HHHHHHHHHHHHT-TTTS-SEEEE-S---B-TTS- CS
  AMP-binding_C   2 vEsalvshpaVaeaaVvGvpdevkGealvafVvlkdgsea.leeeLkahvrkelgpyavpkkvvfvdelpktrsGK 76 
                    +E +l +hp++ + aV+Gvpde  Ge ++afVvl++++   +eee++++v + + p ++ + v+f++e+pk + GK
     EFC36057.1 460 LEGILCKHPKILDSAVIGVPDEEAGELPKAFVVLRPNE-ImTEEEVMEFVSQFVTPQKKIRLVEFIQEIPKSTAGK 534
                    799*******************************8663.3579******************************999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (552 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       437  (0.0243739); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.27s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 3484.61
//
Query:       EFC36058.1  [L=636]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.9e-87  292.8   0.2    2.4e-87  292.4   0.2    1.1  1  Malic_M      Malic enzyme, NAD binding domain
    1.1e-72  243.7   0.0    1.9e-72  242.9   0.0    1.4  1  malic        Malic enzyme, N-terminal domain
  ------ inclusion threshold ------
       0.12   11.5   0.0       0.21   10.8   0.0    1.3  1  Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase


Domain annotation for each model (and alignments):
>> Malic_M  Malic enzyme, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  292.4   0.2   4.1e-91   2.4e-87       1     258 []     327     594 ..     327     594 .. 0.95

  Alignments for each domain:
  == domain 1  score: 292.4 bits;  conditional E-value: 4.1e-91
                 THHHHHHHHHHHHHHHHHH-S-...GGG--EEEEC-SHHHHHHHHHHHHHHHTTTS-HHHHHTTEEEEETTEE-BTT-.S-....--TTTGGGSBS--S CS
     Malic_M   1 iqgTaavalagllaalkitgkk...lseqkivvlGaGsagiGiaeqivealvkeGlseeeakkkiylvDrkGLltedr.ek....leeekkpfakkkee 91 
                 iqgTa+v l+g+l++l++tg++   +++qki+++G+G+ag+G+++ + ea+++eGl+eeea k++y+vD++GLlt++r ++    l++++k+fa  +++
  EFC36058.1 327 IQGTASVILSGVLNCLRATGQSfsdITKQKILIVGSGAAGMGVVSGLKEAMKREGLTEEEALKNFYIVDKDGLLTSERlNEmgstLSDTAKMFAYARND 425
                 9********************9555688***********************************************998644333369************ PP

                 S--S....SHHHHHHHH--SEEEE-SSSSS-S-HHHHHHHHHHSS....S-EEEE--SSGGGSSS-HHHHHHHTTT-SEEEESS----EEE.TSEEE-- CS
     Malic_M  92 lkeakdkltLeevvkkvkptvliGlsgvagafteeivremakste....rPiilplSNPtskaEataedvlkwtdgkalvasGsPfkpvel.ngktyei 185
                 +k   +  +L++vvk++ p++l+G+s+++g+f ee++    + ++     Pi++plSNPtskaE+tae v+k+tdg+a++asGsPf+pv l ng+ +++
  EFC36058.1 426 MK---EGSSLLDVVKQAEPDILLGMSSQPGLFCEEVLTYFNSACKrkgkTPIVFPLSNPTSKAECTAESVFKITDGNAIFASGSPFNPVPLpNGQVIQT 521
                 *9...679*****************************9998888866668************************************************* PP

                 EE--GGGTHHHHHHHHHHTT-SS--HHHHHHHHHHHHTT--HHHHHTT-SS--GGGHHHHHHHHHHHHHHHHH CS
     Malic_M 186 gQaNNayifPglglgvivarakritdemllaaaealaelvseeelkegsllPelseirevslkvavavakaav 258
                 +QaNN++++Pg+gl+++++++++i+d+m++aa+++la +vs+e lk+++++P++++irevs+kva+ v+++a+
  EFC36058.1 522 SQANNMFAYPGVGLAAVLSGCNTISDNMFYAASKSLAATVSDEALKRKEIYPHVEDIREVSKKVAIGVMRQAY 594
                 **********************************************************************996 PP

>> malic  Malic enzyme, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  242.9   0.0   3.2e-76   1.9e-72       1     182 []     137     317 ..     137     317 .. 0.99

  Alignments for each domain:
  == domain 1  score: 242.9 bits;  conditional E-value: 3.2e-76
                 HTTECCCCCCHHCCCHHHHHHHHSTTCHHHHHHHHHHHGGCHHSCCCEGGGETCHHHHHTTSS.SS..EEEEE-SSSBTTTBS-GHHHHHHHHHHHHHH CS
       malic   1 qeknetlfykllkekleellpivYtPtvgeacqeyseeyrkarglylsikdkekikeilknlpeedvkvivvtdgeriLGlGdlGvagvgimvGKlaLy 99 
                 +++netlfy ++ ++++el+pi+YtPtvg+ac+++s+++rk+rg+++s+ dk+++k+++ n+p e+v+vivvtdg riLGlGdlG++g gi++GKl+Ly
  EFC36058.1 137 HDRNETLFYYFIVNNIKELAPIIYTPTVGKACENFSHIFRKPRGMFFSTLDKGEMKSMVYNWPVEEVDVIVVTDGGRILGLGDLGANGDGIPIGKLSLY 235
                 689************************************************************************************************ PP

                 HHHHS-EGGGEEEEEECS-BS.HHHHC.TT..S.SSB...SHHHHHHHHHHHHHHHHHHGCTSEEEE-S--CCHHHHHHHHHC CS
       malic 100 talagidPekvlpvvldvgtnneelledplYlGlrkkRvkgeeydefvdefveavkelfppkaliqfEDfkaknafeileryr 182
                 +a++gi+P +vlpv ldvgtnne+l +dplYlGlr+kR++g ey+e+v+e+v+a+ +++ p++liq+EDf++++a  +l++yr
  EFC36058.1 236 VAAGGINPGRVLPVLLDVGTNNEKLFNDPLYLGLRQKRLTGPEYYELVEEWVDAIVSRW-PNVLIQWEDFSSDKADALLQKYR 317
                 ***********************************************************.**********************8 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   3.6e-05      0.21       2     118 ..     356     516 ..     355     540 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 3.6e-05
                  SEEEE--SHHHHHHHHHHHHHTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHH.......................................... CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......................................... RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaqagakvtlvelegtclnggcllskallgvaedaeias.......................................... 57 
                  +++++G+G+AG+ +   l++a  +  l  +e+++ n+ ++ +  ll +++  e  s                                          
   EFC36058.1 356 KILIVGSGAAGMGVVSGLKEAMKREGLT-EEEALKNFYIVDKDGLLTSERLNEMGStlsdtakmfayarndmkegsslldvvkqaepdillgmssqpg 452
                  799*****************98888888.777777776666666666666555555777888999999999999999998888888888888888888 PP

                  ....HHHHCHHHHCCCCHCCT.CEEEEESCEEEEETEEECTCEEEEEESEEEE---EEE-BCTCT.T CS
                  ....xxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.x RF
  Pyr_redox_2  58 ....evvkklnqgielllgee.vvkidpgkkkvklekkkegdeekiaydklvlAtGssprdlgip.G 118
                      ev++ +n+  ++  +++ v+ + +   k ++++   ++ +ki++++ + A+Gs  +  ++p G
   EFC36058.1 453 lfceEVLTYFNSACKRKGKTPiVFPLSNPTSKAECTA---ESVFKITDGNAIFASGSPFNPVPLPnG 516
                  8886555555555555555566666665555666643...66899***********64444488844 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (636 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       799  (0.0445647); expected 358.6 (0.02)
Passed bias filter:                      666  (0.0371465); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 3739.57
//
Query:       EFC36059.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.4e-18   64.9   4.5    2.8e-16   59.7   0.2    2.4  2  BTB_2         BTB/POZ domain
    0.00036   20.2   4.2     0.0005   19.7   4.2    1.3  1  CENP-K        Centromere-associated protein K
  ------ inclusion threshold ------
       0.17   11.3   7.9       0.23   10.9   7.9    1.2  1  DUF3552       Domain of unknown function (DUF3552)
       0.42   10.1   2.4        0.5    9.9   2.4    1.1  1  Exonuc_VII_L  Exonuclease VII, large subunit


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.7    0.0022       9.8      16      80 ..      13      77 ..       3      97 .. 0.68
   2 !   59.7   0.2   6.1e-20   2.8e-16       1      88 [.     119     209 ..     119     212 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0022
                HHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS....S-B---TTS-HHHHHHH CS
       BTB_2 16 tLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtg...gkLhrpeevelkslleE 80
                 Ls  pd+ L++  + +  ++  e++ +  fD  +  Fe iLn y+ +    +L + +  + ++ll+E
  EFC36059.1 13 SLS-SPDSSLTSSSSSN-FESLFEKS-KSQFDQISLEFELILNTYKLKsqkLDLTERKLTKKEKLLKE 77
                455.6777777777755.55555544.445788888*******9987652345555555566666666 PP

  == domain 2  score: 59.7 bits;  conditional E-value: 6.1e-20
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS....S-B---TTS-HHHHHHHHHHHT--T CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtg...gkLhrpeevelkslleElefyglee 88 
                 vkl++gG++f t+ stL+   dt+++   + +   ++++++n++f+DR ++ F+ iLny+r      k+   +e +l+ + eE+ +y+l++
  EFC36059.1 119 VKLDIGGKIFVTTLSTLTSVKDTFFTGYFNDHFNPTVEDDDNSFFIDRPNEQFHLILNYLRGIdikCKIASLNECDLNDFIEEIVYYQLTP 209
                 89*************************9996659999************************833235666778999************986 PP

>> CENP-K  Centromere-associated protein K
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   4.2   1.1e-07    0.0005      58     165 ..      10     120 ..       2     174 .. 0.62

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 1.1e-07
      CENP-K  58 LtaeleqwekktpeiislneevllalgkeelqklksqLelvlsiiqsk.........nkklkedLkrEqewleeqqeilesLkektkelkkqvvafsek 147
                 L + l+   ++     s n e l++ +k+++++++ + el+l++ ++k         +      L++  + l+e++  l+  + + ke ++    + +k
  EFC36059.1  10 LFSSLSSPDSSLTSSSSSNFESLFEKSKSQFDQISLEFELILNTYKLKsqkldlterK------LTKKEKLLKERELHLNERETIVKEHEEYFNCLEKK 102
                 5555555566666667899*****************************5555555550......55555555555555444444444444444444444 PP

      CENP-K 148 trksaelkekirkikeyk 165
                  ++ + +++k  k ++ k
  EFC36059.1 103 LSITTTIETKLGKNQKVK 120
                 444555555544444333 PP

>> DUF3552  Domain of unknown function (DUF3552)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   7.9   5.1e-05      0.23      73     140 ..      54     121 ..      27     123 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 5.1e-05
     DUF3552  73 lkerrnelqrlekRllqkeetLdrkeeslekkeesleekekelkqkeqsleekeeeleelveeqrqeL 140
                 +k + ++l+  e++l +ke+ L+++e +l+++e+ ++e+e+  +  e++l+ + +  ++l ++q+ +L
  EFC36059.1  54 YKLKSQKLDLTERKLTKKEKLLKERELHLNERETIVKEHEEYFNCLEKKLSITTTIETKLGKNQKVKL 121
                 56678888899999999999999999999999999999999988888888777766666666666665 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   2.4   0.00011       0.5     178     258 ..      26     105 ..       3     140 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00011
  Exonuc_VII_L 178 lkspeellerkrqrldeleerleralkkqlkkkrerleelkerlkekleekkerlkklkerlelleekkerleeleeklea 258
                    ++ e+l+e++++++d+++ ++e  + +++k k+++l+ ++++l++k +  ker  +l+er ++++e++e ++ le+kl+ 
    EFC36059.1  26 SSNFESLFEKSKSQFDQISLEFEL-ILNTYKLKSQKLDLTERKLTKKEKLLKERELHLNERETIVKEHEEYFNCLEKKLSI 105
                   235666777777777777666666.66666666666666665553222222222233333333555555555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1220  (0.0680462); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1417.48
//
Query:       EFC36060.1  [L=657]
Description: hypothetical protein NAEGRDRAFT_82308 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (657 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1041  (0.0580624); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 4072.19
//
Query:       EFC36061.1  [L=530]
Description: leucine aminopeptidase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   9.3e-105  350.3   0.0   1.2e-104  349.9   0.0    1.1  1  Peptidase_M17    Cytosol aminopeptidase family, catalytic dom
  ------ inclusion threshold ------
      0.027   14.3   1.8      0.053   13.4   0.1    2.4  3  Peptidase_M17_N  Cytosol aminopeptidase family, N-terminal do


Domain annotation for each model (and alignments):
>> Peptidase_M17  Cytosol aminopeptidase family, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  349.9   0.0  1.4e-108  1.2e-104       2     310 ..     206     521 ..     205     522 .. 0.91

  Alignments for each domain:
  == domain 1  score: 349.9 bits;  conditional E-value: 1.4e-108
                    HHHHHHHS-TTTS-HHHHHHHHHHHHTCCT..........EEEEEEEECHHHHHTT-HHHHHHHTTSSSS--EEEEEEEE-SS...TTSEEEEEEE CS
  Peptidase_M17   2 lardlvntpaneltpeklaeeaeelakeag..........kvevevldeeeleekgmgallaVgkgSeeepprlveleykgak...ekekklalVG 84 
                    ++r + + pan++tp k+++  +   ++++          k +++v+dee++++kgmg++l+V++g+ + p+r++e+ y++++   ++e +la+ G
     EFC36061.1 206 FSRYILELPANYCTPIKYCDLLKLKIEKYSlfvsqeflsaKSKINVYDEEWAKSKGMGSFLSVTAGT-SAPARVLEVVYTNNSqkkADEYDLAILG 300
                    57999***************65432222223444445556789***********************9.56**********99977778889***** PP

                    EEEEEEE-TTSS--HHHHTTGGGGGHHHHHHHHHHHHHHHHT-SSEEEEEEEEEEE--STTSTTTTEEEE-TTS-EEEES-TTGCHHHHHHHHHHH CS
  Peptidase_M17  85 KGitfDtGGlslKpsasmeemkaDmgGAAavlgalkavaelklpvnvvavlplaeNmisgkavkpgdvitamnGktvevlnTDaEGRLvLADalay 180
                    KGitfD+GG+slKp+++m+emk+D+gG++a++ga+ a+ el+lp+n+++v++l+eNm++++a+kpgdv+ amnGkt+ev+nTDaEGRL+LAD+l+y
     EFC36061.1 301 KGITFDSGGISLKPGEGMKEMKGDCGGSSAAFGAAVAALELELPLNIITVAMLCENMPGPDATKPGDVVIAMNGKTIEVDNTDAEGRLILADGLCY 396
                    ************************************************************************************************ PP

                    HHGCT--SEEEEEE---THHHHHHTTTSEEEEES-HHHHHHHHHHHHHHS-EEEE----HH.HGGGG--SSSSEESS-SSSSTHHHHHHHHHHTTS CS
  Peptidase_M17 181 aeekekpdlivdvATLTgavvvalGkkaaglfsnddelaeelekageeagervwrlpleee.ykkqlkskvaDlknvgkkrragaitAalFLkefv 275
                     + +++p++++d+ATLTgav++al++ +a++++n++el + leka+ ++++ +wr+p++++ y  q+ks+v D++n+g+ r +g++tAa FL+efv
     EFC36061.1 397 LS-EKQPEVLLDMATLTGAVIIALSHVTAAVYTNSHELFAGLEKASYQTNDYLWRMPIFRDeYLGQMKSDVSDYNNIGG-RPGGSCTAATFLSEFV 490
                    *6.67****************************************************99988*****************.999************* PP

                    ..SE.CGEEEEE-TTTTES.BTTB.S..EE--TTHHHH CS
  Peptidase_M17 276 ..ke.tpWaHlDiagtalkekealkkekgatGvgvrtL 310
                      ++ ++WaHlDia+++      +k  +g tG+++r++
     EFC36061.1 491 dfSKvKKWAHLDIAAVTH-----TK--AGYTGRPTRAI 521
                    8856678********982.....22..499****9987 PP

>> Peptidase_M17_N  Cytosol aminopeptidase family, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.36   3.2e+03       1      16 [.       6      22 ..       6      32 .. 0.77
   2 ?   13.4   0.1     6e-06     0.053      55     120 ..      70     159 ..      59     160 .. 0.72
   3 ?   -2.8   0.1      0.58   5.2e+03     102     122 ..     426     447 ..     412     448 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.36
  Peptidase_M17_N  1 vvgvf.eggklspaaek 16
                     vvgvf  +gkls++a+ 
       EFC36061.1  6 VVGVFgTDGKLSTTAQT 22
                     89999999999998854 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 6e-06
  Peptidase_M17_N  55 vllVGLGkeee...........................ltaealrkaagaaaralkg.akvttiavalplegknsdekaeaaaegallglYrfd 120
                      +++VG+ ++e+                              +++r  + + ++++k+ +k ++ +++++    + +++ +a+aega+l++++fd
       EFC36061.1  70 IVFVGVAQKEKkptenssvfelssqysqqavadrhefvTLNQSIRNQVTTLVESIKKdKKDEKFVIYFD----DFNGHSQAVAEGAALATWKFD 159
                      55555555555555555555555555555555555554445789999999999**99888889999999....556*****************8 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 0.58
  Peptidase_M17_N 102 d.ekaeaaaegallglYrfdry 122
                        ++ +++  g++ ++Y+ ++y
       EFC36061.1 426 VyTNSHELFAGLEKASYQTNDY 447
                      2467788889999999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (530 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       902  (0.0503096); expected 358.6 (0.02)
Passed bias filter:                      627  (0.0349713); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 3443.07
//
Query:       EFC36062.1  [L=109]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       731  (0.0407719); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.31s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 705.82
//
Query:       EFC36063.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-25   87.8   6.0    9.4e-08   31.7   0.1    4.2  5  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.03   13.6   0.1      0.047   13.0   0.1    1.3  1  PARG_cat  Poly (ADP-ribose) glycohydrolase (PARG)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       1.1     1e+04       9      19 ..      24      34 ..      21      39 .. 0.64
   2 !   19.4   0.1   7.2e-08   0.00064       6      35 ..      50      79 ..      49      97 .. 0.84
   3 !   31.7   0.1     1e-11   9.4e-08       1      49 []      99     152 ..      99     152 .. 0.88
   4 !   29.7   0.1   4.3e-11   3.8e-07      13      49 .]     141     177 ..     137     177 .. 0.92
   5 !   27.8   0.0   1.6e-10   1.5e-06       1      38 [.     154     191 ..     154     208 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 1.1
     DUF4116  9 vkkngsalkyl 19
                +  n++ ++y+
  EFC36063.1 24 INVNPEDIEYV 34
                45566666664 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 7.2e-08
     DUF4116  6 leavkkngsalkylseeLknDkeivlkAvk 35
                 +a+++ +  +++ls++Lk+ ke++ kA+ 
  EFC36063.1 50 AKALEHSPTTYRFLSDRLKKKKEFIEKAII 79
                589*************************85 PP

  == domain 3  score: 31.7 bits;  conditional E-value: 1e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt.....alsyaseeLr 49 
                 Dr i++ av+   ++++y+seeL+  k +v+  + ++       +++y+s++L+
  EFC36063.1  99 DRSIMTMAVRETTNCFQYASEELRDSKSFVMDTIDSCRMngdssFMYYISDKLK 152
                 99******************************98876643445589*****997 PP

  == domain 4  score: 29.7 bits;  conditional E-value: 4.3e-11
     DUF4116  13 gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +s  +y+s++Lk D +++++ +kq ++a+ yas+ Lr
  EFC36063.1 141 SSFMYYISDKLKDDEDVIMAGIKQFSSAFGYASNRLR 177
                 556789****************************998 PP

  == domain 5  score: 27.8 bits;  conditional E-value: 1.6e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 D+++++  +k+++sa+ y+s++L+n+ ++++ A+ ++ 
  EFC36063.1 154 DEDVIMAGIKQFSSAFGYASNRLRNNLNFAMDALTIDN 191
                 99*******************************98765 PP

>> PARG_cat  Poly (ADP-ribose) glycohydrolase (PARG)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   5.2e-06     0.047     195     226 ..     147     179 ..     136     207 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 5.2e-06
    PARG_cat 195 fteklednealvivgaerfssytGYass.frfa 226
                 +++kl+d e +++ g+++fss  GYas+ +r +
  EFC36063.1 147 ISDKLKDDEDVIMAGIKQFSSAFGYASNrLRNN 179
                 7899*********************96514444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       587  (0.0327403); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1560.52
//
Query:       EFC36064.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.7e-60  194.1   4.8     0.0043   17.0   0.0   14.1 14  LRR_6     Leucine Rich repeat
    7.2e-48  160.2  22.1    4.6e-09   35.9   0.0    6.2  7  LRR_8     Leucine rich repeat
    6.9e-42  140.8  32.9    0.00028   21.2   0.1    8.2 13  LRR_4     Leucine Rich repeats (2 copies)
    5.8e-26   87.0   0.0         19    6.3   0.0   13.8 14  LRR_1     Leucine Rich Repeat
    2.3e-16   59.4   1.2        0.3   11.1   0.0    9.9 11  RHH_3     Ribbon-helix-helix domain
  ------ inclusion threshold ------
        4.2    7.1   8.7         12    5.7   0.2    3.6  5  UPF0193   Uncharacterised protein family (UPF0193)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0    0.0005       1.5       4      19 ..       3      18 ..       1      23 [. 0.87
   2 !   13.0   0.0   2.8e-05     0.085       5      24 .]      28      47 ..      25      47 .. 0.92
   3 !   10.7   0.0   0.00015      0.44       4      19 ..      51      66 ..      48      71 .. 0.88
   4 !   12.9   0.0     3e-05     0.089       5      19 ..      76      90 ..      73      95 .. 0.88
   5 !    9.8   0.0    0.0003       0.9       4      19 ..      99     114 ..      96     119 .. 0.87
   6 !   16.3   0.0   2.5e-06    0.0074       5      24 .]     124     143 ..     121     143 .. 0.92
   7 !   10.5   0.0   0.00018      0.53       4      19 ..     147     162 ..     144     167 .. 0.87
   8 !   17.0   0.0   1.4e-06    0.0043       5      24 .]     172     191 ..     169     191 .. 0.92
   9 !   14.4   0.0   9.7e-06     0.029       4      19 ..     195     210 ..     192     215 .. 0.88
  10 !   11.2   0.0   0.00011      0.32       5      19 ..     220     234 ..     217     239 .. 0.88
  11 !   14.4   0.0   9.7e-06     0.029       4      19 ..     243     258 ..     240     263 .. 0.88
  12 !   16.6   0.0   1.9e-06    0.0058       5      24 .]     268     287 ..     265     287 .. 0.92
  13 !   14.4   0.0   9.7e-06     0.029       4      19 ..     291     306 ..     288     311 .. 0.88
  14 !    9.1   0.0    0.0005       1.5       5      16 ..     316     327 ..     313     329 .] 0.90

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0005
       LRR_6  4 hLteLdLsgNdIgDeG 19
                 Lt+Ld+ +N+Ig eG
  EFC36064.1  3 QLTSLDMHSNEIGVEG 18
                69***********999 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 2.8e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+ +N+Ig eGa+ ++
  EFC36064.1 28 LTSLDIYSNEIGVEGAKYIS 47
                9***************9885 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00015
       LRR_6  4 hLteLdLsgNdIgDeG 19
                +Lt+Ld+ +N+Ig eG
  EFC36064.1 51 SLTSLDIHSNEIGVEG 66
                8************999 PP

  == domain 4  score: 12.9 bits;  conditional E-value: 3e-05
       LRR_6  5 LteLdLsgNdIgDeG 19
                Lt+L++ +N+Ig eG
  EFC36064.1 76 LTSLNIGYNQIGVEG 90
                9***********999 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.0003
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                  Lt+Ld+ +N+Ig eG
  EFC36064.1  99 QLTSLDIHSNEIGVEG 114
                 69***********999 PP

  == domain 6  score: 16.3 bits;  conditional E-value: 2.5e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N+I+ eGa+ ++
  EFC36064.1 124 LTSLNIGYNQISVEGAKYIS 143
                 9***************9885 PP

  == domain 7  score: 10.5 bits;  conditional E-value: 0.00018
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 +Lt+L + +N+Ig eG
  EFC36064.1 147 SLTSLYIGYNQIGVEG 162
                 8************999 PP

  == domain 8  score: 17.0 bits;  conditional E-value: 1.4e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N+Ig eGa+ ++
  EFC36064.1 172 LTSLNIGHNEIGEEGAKYIS 191
                 9***************9885 PP

  == domain 9  score: 14.4 bits;  conditional E-value: 9.7e-06
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 +Lt+L++ +N+Ig eG
  EFC36064.1 195 SLTSLNIGYNQIGVEG 210
                 8************999 PP

  == domain 10  score: 11.2 bits;  conditional E-value: 0.00011
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt+L++ +N+I+ eG
  EFC36064.1 220 LTSLNIGHNEISVEG 234
                 9***********999 PP

  == domain 11  score: 14.4 bits;  conditional E-value: 9.7e-06
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 +Lt+L++ +N+Ig eG
  EFC36064.1 243 SLTSLNIGYNQIGVEG 258
                 8************999 PP

  == domain 12  score: 16.6 bits;  conditional E-value: 1.9e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N+Ig eGa+ ++
  EFC36064.1 268 LTSLNIGYNEIGVEGAKYIS 287
                 9***************9885 PP

  == domain 13  score: 14.4 bits;  conditional E-value: 9.7e-06
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 +Lt+L++ +N+Ig eG
  EFC36064.1 291 SLTSLNIGYNQIGVEG 306
                 8************999 PP

  == domain 14  score: 9.1 bits;  conditional E-value: 0.0005
       LRR_6   5 LteLdLsgNdIg 16 
                 Lt+L++ +N+Ig
  EFC36064.1 316 LTSLNIGHNEIG 327
                 9**********9 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.1   1.5e-09   4.5e-06       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   29.6   0.5   1.4e-10   4.3e-07       2      61 .]      51     110 ..      50     110 .. 0.98
   3 !   35.9   0.0   1.6e-12   4.6e-09       2      61 .]      99     158 ..      98     158 .. 0.98
   4 !   21.9   0.0   3.6e-08   0.00011      23      61 .]     168     206 ..     162     206 .. 0.75
   5 !   34.6   0.5   3.9e-12   1.2e-08       2      61 .]     195     254 ..     194     254 .. 0.98
   6 !   32.8   0.3   1.4e-11   4.3e-08       2      61 .]     219     278 ..     218     278 .. 0.98
   7 !   32.7   0.0   1.5e-11   4.5e-08       2      61 .]     267     326 ..     266     326 .. 0.98

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 1.5e-09
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsLd ++N + + + +  + +++L++Ld+ +N++ +  ++ +s ++sL+sLd+ +N +
  EFC36064.1  3 QLTSLDMHSNEIGVEGSKYISEMKQLTSLDIYSNEIGVEGAKYISEMKSLTSLDIHSNEI 62
                79********************************************************87 PP

  == domain 2  score: 29.6 bits;  conditional E-value: 1.4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+++N + + + +  + +++L++L++++N++ +   + +s +++L+sLd+ +N +
  EFC36064.1  51 SLTSLDIHSNEIGVEGSKYISEMKQLTSLNIGYNQIGVEGSKYISEMNQLTSLDIHSNEI 110
                 7*********************************************************87 PP

  == domain 3  score: 35.9 bits;  conditional E-value: 1.6e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+++N + + + +  + +++L++L++++N++++  ++ +sg++sL+sL++ +N++
  EFC36064.1  99 QLTSLDIHSNEIGVEGSKYISEMKQLTSLNIGYNQISVEGAKYISGMKSLTSLYIGYNQI 158
                 79********************************************************98 PP

  == domain 4  score: 21.9 bits;  conditional E-value: 3.6e-08
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  +++L++L++++N++    ++ +sg++sL+sL++ +N++
  EFC36064.1 168 EMKQLTSLNIGHNEIGEEGAKYISGMKSLTSLNIGYNQI 206
                 577788888888888888888888888888888888876 PP

  == domain 5  score: 34.6 bits;  conditional E-value: 3.9e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  N++ + + +  + +++L++L++++N++++   + +sg++sL+sL++ +N++
  EFC36064.1 195 SLTSLNIGYNQIGVEGSKYISEMKQLTSLNIGHNEISVEGSKYISGMKSLTSLNIGYNQI 254
                 7*********************************************************98 PP

  == domain 6  score: 32.8 bits;  conditional E-value: 1.4e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++ +N +++ + +  +g+++L++L++++N++ +   + +s +++L+sL++ +N +
  EFC36064.1 219 QLTSLNIGHNEISVEGSKYISGMKSLTSLNIGYNQIGVEGSKYISEMKQLTSLNIGYNEI 278
                 7*********************************************************86 PP

  == domain 7  score: 32.7 bits;  conditional E-value: 1.5e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  N + + + +  +g+++L++L++++N++ +   + +s +++L+sL++ +N +
  EFC36064.1 267 QLTSLNIGYNEIGVEGAKYISGMKSLTSLNIGYNQIGVEGSKYISEMKQLTSLNIGHNEI 326
                 7*********************************************************87 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.0   1.6e-05     0.047       2      35 ..       3      37 ..       2      42 .. 0.82
   2 !   17.0   0.1     2e-06    0.0059       1      36 [.      26      62 ..      26      69 .. 0.82
   3 !   18.2   0.1   8.2e-07    0.0024       1      36 [.      50      86 ..      50      92 .. 0.82
   4 !   16.5   0.1   2.8e-06    0.0085       1      36 [.      74     110 ..      74     118 .. 0.83
   5 !   17.6   0.1   1.3e-06    0.0039       2      38 ..      99     135 ..      98     141 .. 0.81
   6 !   20.5   0.0   1.5e-07   0.00046       1      36 [.     122     158 ..     122     164 .. 0.83
   7 !   19.2   0.0   3.9e-07    0.0012       1      36 [.     146     182 ..     146     187 .. 0.82
   8 !   20.1   0.0   2.1e-07   0.00063       1      36 [.     170     206 ..     170     216 .. 0.86
   9 !   19.8   0.1   2.6e-07   0.00076       1      38 [.     194     231 ..     194     237 .. 0.80
  10 !   21.2   0.1   9.3e-08   0.00028       1      36 [.     218     254 ..     218     261 .. 0.84
  11 !   17.9   0.1     1e-06     0.003       1      36 [.     242     278 ..     242     285 .. 0.82
  12 !   17.7   0.0   1.2e-06    0.0036       1      36 [.     266     302 ..     266     309 .. 0.83
  13 !   19.0   0.1   4.6e-07    0.0014       1      36 [.     290     326 ..     290     328 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.6e-05
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35
                +L++Ld ++N +   ++  ++ +++L++Ld+ +N  
  EFC36064.1  3 QLTSLDMHSNEIGVEGSkyISEMKQLTSLDIYSN-E 37
                69***********777776445*********777.3 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 2e-06
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++Ld+ +N +   +   ++ +++L++Ld+++N  i
  EFC36064.1 26 KQLTSLDIYSNEIGVEGAkyISEMKSLTSLDIHSN-EI 62
                58************766676445*********777.44 PP

  == domain 3  score: 18.2 bits;  conditional E-value: 8.2e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++Ld+++N +   ++  ++ +++L++L++ g n+i
  EFC36064.1 50 KSLTSLDIHSNEIGVEGSkyISEMKQLTSLNI-GYNQI 86
                68************777776445*********.55587 PP

  == domain 4  score: 16.5 bits;  conditional E-value: 2.8e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ Nq+   ++  ++ + +L++Ld+++N  i
  EFC36064.1  74 KQLTSLNIGYNQIGVEGSkyISEMNQLTSLDIHSN-EI 110
                 58************777776445*********777.44 PP

  == domain 5  score: 17.6 bits;  conditional E-value: 1.3e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +L++Ld+++N +   ++  ++ +++L++L++ g n+i +
  EFC36064.1  99 QLTSLDIHSNEIGVEGSkyISEMKQLTSLNI-GYNQI-S 135
                 69***********777776445*********.55588.5 PP

  == domain 6  score: 20.5 bits;  conditional E-value: 1.5e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ Nq++  +   ++++++L++L++ g n+i
  EFC36064.1 122 KQLTSLNIGYNQISVEGAkyISGMKSLTSLYI-GYNQI 158
                 58************766686668*********.55587 PP

  == domain 7  score: 19.2 bits;  conditional E-value: 3.9e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ Nq+   ++  ++ +++L++L++ +N  i
  EFC36064.1 146 KSLTSLYIGYNQIGVEGSkyISEMKQLTSLNIGHN-EI 182
                 68************777776445*********666.55 PP

  == domain 8  score: 20.1 bits;  conditional E-value: 2.1e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L++++N + + +   ++++++L++L++ g n+i
  EFC36064.1 170 KQLTSLNIGHNEIGEEGAkyISGMKSLTSLNI-GYNQI 206
                 58************988887668*********.55587 PP

  == domain 9  score: 19.8 bits;  conditional E-value: 2.6e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L+++ Nq+   ++  ++ +++L++L++ +N  i +
  EFC36064.1 194 KSLTSLNIGYNQIGVEGSkyISEMKQLTSLNIGHN-EI-S 231
                 68************777776445*********666.66.4 PP

  == domain 10  score: 21.2 bits;  conditional E-value: 9.3e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L++++N ++  ++  ++++++L++L++ g n+i
  EFC36064.1 218 KQLTSLNIGHNEISVEGSkyISGMKSLTSLNI-GYNQI 254
                 58************777776668*********.55587 PP

  == domain 11  score: 17.9 bits;  conditional E-value: 1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ Nq+   ++  ++ +++L++L++  N  i
  EFC36064.1 242 KSLTSLNIGYNQIGVEGSkyISEMKQLTSLNIGYN-EI 278
                 68************777776445*********666.44 PP

  == domain 12  score: 17.7 bits;  conditional E-value: 1.2e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ N +   +   ++++++L++L++ g n+i
  EFC36064.1 266 KQLTSLNIGYNEIGVEGAkyISGMKSLTSLNI-GYNQI 302
                 58************766686668*********.55587 PP

  == domain 13  score: 19.0 bits;  conditional E-value: 4.6e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ Nq+   ++  ++ +++L++L++ +N  i
  EFC36064.1 290 KSLTSLNIGYNQIGVEGSkyISEMKQLTSLNIGHN-EI 326
                 68************777776445*********667.54 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0       0.1     3e+02       1      20 [.       3      22 ..       3      25 .. 0.79
   2 ?    3.2   0.0     0.066     2e+02       1      18 [.      27      44 ..      27      49 .. 0.77
   3 ?    4.1   0.0     0.035     1e+02       1      20 [.      51      70 ..      51      73 .. 0.80
   4 ?    5.7   0.0      0.01        31       1      20 [.      75      94 ..      75      97 .. 0.81
   5 ?    3.8   0.0     0.042   1.3e+02       1      20 [.      99     118 ..      99     121 .. 0.80
   6 ?    5.3   0.0     0.013        40       1      21 [.     123     143 ..     123     145 .. 0.79
   7 ?    4.8   0.0     0.019        58       1      20 [.     147     166 ..     147     169 .. 0.81
   8 ?    5.3   0.0     0.013        39       1      19 [.     171     189 ..     171     193 .. 0.77
   9 !    5.9   0.0    0.0085        25       1      20 [.     195     214 ..     195     217 .. 0.81
  10 !    6.3   0.0    0.0064        19       1      21 [.     219     239 ..     219     241 .. 0.83
  11 !    5.9   0.0    0.0085        25       1      20 [.     243     262 ..     243     265 .. 0.81
  12 ?    4.7   0.0     0.022        65       1      20 [.     267     286 ..     267     289 .. 0.78
  13 !    5.9   0.0    0.0085        25       1      20 [.     291     310 ..     291     313 .. 0.81
  14 ?    3.8   0.0     0.042   1.3e+02       1      12 [.     315     326 ..     315     329 .] 0.86

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.1
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++Ld+ +n ++  ++ ++
  EFC36064.1  3 QLTSLDMHSNEIGVEGSKYI 22
                599*******9977777665 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.066
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++Ld+ +n ++  ++ 
  EFC36064.1 27 QLTSLDIYSNEIGVEGAK 44
                599*******98666555 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.035
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++Ld+ +n ++  ++ ++
  EFC36064.1 51 SLTSLDIHSNEIGVEGSKYI 70
                69********9977777665 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.01
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++L++++n+++  ++ ++
  EFC36064.1 75 QLTSLNIGYNQIGVEGSKYI 94
                599********987777666 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.042
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+ +n ++  ++ ++
  EFC36064.1  99 QLTSLDIHSNEIGVEGSKYI 118
                 599*******9977777665 PP

  == domain 6  score: 5.3 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++++n+++  ++ +++
  EFC36064.1 123 QLTSLNIGYNQISVEGAKYIS 143
                 599********9877766665 PP

  == domain 7  score: 4.8 bits;  conditional E-value: 0.019
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n+++  ++ ++
  EFC36064.1 147 SLTSLYIGYNQIGVEGSKYI 166
                 69*********987777666 PP

  == domain 8  score: 5.3 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L++++n ++  ++ +
  EFC36064.1 171 QLTSLNIGHNEIGEEGAKY 189
                 599*******997666655 PP

  == domain 9  score: 5.9 bits;  conditional E-value: 0.0085
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n+++  ++ ++
  EFC36064.1 195 SLTSLNIGYNQIGVEGSKYI 214
                 69*********987777666 PP

  == domain 10  score: 6.3 bits;  conditional E-value: 0.0064
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++++n ++  ++ +++
  EFC36064.1 219 QLTSLNIGHNEISVEGSKYIS 239
                 599********9888887776 PP

  == domain 11  score: 5.9 bits;  conditional E-value: 0.0085
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n+++  ++ ++
  EFC36064.1 243 SLTSLNIGYNQIGVEGSKYI 262
                 69*********987777666 PP

  == domain 12  score: 4.7 bits;  conditional E-value: 0.022
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n ++  ++ ++
  EFC36064.1 267 QLTSLNIGYNEIGVEGAKYI 286
                 599*******9977666665 PP

  == domain 13  score: 5.9 bits;  conditional E-value: 0.0085
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n+++  ++ ++
  EFC36064.1 291 SLTSLNIGYNQIGVEGSKYI 310
                 69*********987777666 PP

  == domain 14  score: 3.8 bits;  conditional E-value: 0.042
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++++n +
  EFC36064.1 315 QLTSLNIGHNEI 326
                 599*******87 PP

>> RHH_3  Ribbon-helix-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0   0.00065       1.9      12      35 ..       2      25 ..       1      25 [. 0.93
   2 !   11.1   0.0   9.9e-05       0.3      12      35 ..      26      49 ..      24      53 .. 0.93
   3 !    7.1   0.0    0.0018       5.3      14      35 ..      52      73 ..      48      73 .. 0.89
   4 ?    2.1   0.0     0.066     2e+02      13      35 ..      75      97 ..      72      97 .. 0.78
   5 !    9.9   0.0   0.00024      0.71      12      35 ..      98     121 ..      96     121 .. 0.93
   6 ?    0.5   0.0       0.2   5.9e+02      22      35 ..     156     169 ..     156     169 .. 0.87
   7 ?    0.9   0.0      0.15   4.5e+02      22      35 ..     204     217 ..     196     217 .. 0.87
   8 ?    3.1   0.0     0.031        94      12      32 ..     218     238 ..     216     239 .. 0.92
   9 ?    0.9   0.0      0.15   4.4e+02      22      35 ..     252     265 ..     244     265 .. 0.87
  10 ?   -2.9   0.0       2.3   6.9e+03      16      32 ..     270     286 ..     266     286 .. 0.71
  11 ?    0.9   0.0      0.15   4.4e+02      22      35 ..     300     313 ..     292     313 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00065
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+  S++++++ Sk++ e+
  EFC36064.1  2 NQLTSLDMHSNEIGVEGSKYISEM 25
                7999*****************886 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 9.9e-05
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+ +S++++++ +k++ e+
  EFC36064.1 26 KQLTSLDIYSNEIGVEGAKYISEM 49
                6999*****************886 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0018
       RHH_3 14 aekLkaLSekTrIprSklldeA 35
                +++L+  S++++++ Sk++ e+
  EFC36064.1 52 LTSLDIHSNEIGVEGSKYISEM 73
                5789999************886 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.066
       RHH_3 13 laekLkaLSekTrIprSklldeA 35
                ++++L+   ++++++ Sk++ e+
  EFC36064.1 75 QLTSLNIGYNQIGVEGSKYISEM 97
                56666666689*********886 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00024
       RHH_3  12 elaekLkaLSekTrIprSklldeA 35 
                 +++++L+  S++++++ Sk++ e+
  EFC36064.1  98 NQLTSLDIHSNEIGVEGSKYISEM 121
                 799******************886 PP

  == domain 6  score: 0.5 bits;  conditional E-value: 0.2
       RHH_3  22 ekTrIprSklldeA 35 
                 ++++++ Sk++ e+
  EFC36064.1 156 NQIGVEGSKYISEM 169
                 589********886 PP

  == domain 7  score: 0.9 bits;  conditional E-value: 0.15
       RHH_3  22 ekTrIprSklldeA 35 
                 ++++++ Sk++ e+
  EFC36064.1 204 NQIGVEGSKYISEM 217
                 689********886 PP

  == domain 8  score: 3.1 bits;  conditional E-value: 0.031
       RHH_3  12 elaekLkaLSekTrIprSkll 32 
                 +++++L+  +++++++ Sk++
  EFC36064.1 218 KQLTSLNIGHNEISVEGSKYI 238
                 68999***************8 PP

  == domain 9  score: 0.9 bits;  conditional E-value: 0.15
       RHH_3  22 ekTrIprSklldeA 35 
                 ++++++ Sk++ e+
  EFC36064.1 252 NQIGVEGSKYISEM 265
                 689********886 PP

  == domain 10  score: -2.9 bits;  conditional E-value: 2.3
       RHH_3  16 kLkaLSekTrIprSkll 32 
                 +L+   ++++++ +k++
  EFC36064.1 270 SLNIGYNEIGVEGAKYI 286
                 55555578999999997 PP

  == domain 11  score: 0.9 bits;  conditional E-value: 0.15
       RHH_3  22 ekTrIprSklldeA 35 
                 ++++++ Sk++ e+
  EFC36064.1 300 NQIGVEGSKYISEM 313
                 689********886 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.2    0.0039        12     171     207 ..      18      54 ..       8      62 .. 0.89
   2 ?    4.9   0.1    0.0065        19     170     207 ..      41      78 ..      35      81 .. 0.91
   3 ?    4.1   0.1     0.012        35     172     207 ..      91     126 ..      84     130 .. 0.92
   4 ?   -1.5   0.1      0.61   1.8e+03     169     206 ..     184     221 ..     160     230 .. 0.67
   5 ?   -2.5   0.0       1.2   3.6e+03     172     205 ..     211     244 ..     203     248 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0039
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                   ++++eM++L   + Y+++I  e ++ + e+++l +
  EFC36064.1  18 GSKYISEMKQLTSLDIYSNEIGVEGAKYISEMKSLTS 54 
                 5789*****************************9976 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0065
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 e +++++eM++L   + ++++I  e s+ + e+++l +
  EFC36064.1  41 EGAKYISEMKSLTSLDIHSNEIGVEGSKYISEMKQLTS 78 
                 55799*****************************9975 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.012
     UPF0193 172 keFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                  ++++eM++L   + ++++I  e s+ + e+++l +
  EFC36064.1  91 SKYISEMNQLTSLDIHSNEIGVEGSKYISEMKQLTS 126
                 6899****************************9975 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 0.61
     UPF0193 169 eeRkeFLeeMeaLGqgkkYraiIeteIsqklreleald 206
                 ee +++++ M++L   +   + I  e s+ + e+++l 
  EFC36064.1 184 EEGAKYISGMKSLTSLNIGYNQIGVEGSKYISEMKQLT 221
                 34556666666666666666667777777777777665 PP

  == domain 5  score: -2.5 bits;  conditional E-value: 1.2
     UPF0193 172 keFLeeMeaLGqgkkYraiIeteIsqklreleal 205
                  ++++eM++L   +  +++I  e s+ +  +++l
  EFC36064.1 211 SKYISEMKQLTSLNIGHNEISVEGSKYISGMKSL 244
                 5777888888888888888888888888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       188  (0.0104858); expected 358.6 (0.02)
Passed bias filter:                      100  (0.00557756); expected 358.6 (0.02)
Passed Vit filter:                         7  (0.000390429); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2037.15
//
Query:       EFC36065.1  [L=103]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      4e-18   63.9   0.0       0.01   15.8   0.0    4.1  4  LRR_6            Leucine Rich repeat
    1.1e-11   44.3   1.6      8e-08   31.9   0.1    2.1  2  LRR_8            Leucine rich repeat
    2.5e-10   40.5   0.1    0.00051   20.4   0.0    2.5  2  LRR_4            Leucine Rich repeats (2 copies)
    3.1e-09   36.6   0.2      0.043   13.8   0.0    3.8  4  RHH_3            Ribbon-helix-helix domain
      4e-06   26.6   0.0         28    5.8   0.0    4.2  4  LRR_1            Leucine Rich Repeat
     0.0088   15.9   2.4        1.8    8.3   0.2    2.0  2  UPF0193          Uncharacterised protein family (UPF0193)
  ------ inclusion threshold ------
      0.058   13.2   0.1        1.9    8.3   0.0    2.3  2  Nucleic_acid_bd  Putative nucleic acid-binding region
       0.68   10.1   4.4         16    5.7   0.1    2.8  4  DUF2634          Protein of unknown function (DUF2634)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0     1e-05     0.023       4      19 ..       3      18 ..       1      23 [. 0.87
   2 !   14.0   0.0   1.8e-05      0.04       4      24 .]      27      47 ..      24      47 .. 0.91
   3 !   15.0   0.0   8.5e-06     0.019       4      19 ..      51      66 ..      48      71 .. 0.87
   4 !   15.8   0.0   4.7e-06      0.01       4      24 .]      75      95 ..      72      95 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1e-05
       LRR_6  4 hLteLdLsgNdIgDeG 19
                 Lt+Ld+ +N+Ig eG
  EFC36065.1  3 QLTSLDIHYNQIGAEG 18
                69*************9 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 1.8e-05
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                +Lt+Ld+ +N+Ig eGa+ ++
  EFC36065.1 27 SLTSLDIYSNEIGIEGAKYIS 47
                8****************9885 PP

  == domain 3  score: 15.0 bits;  conditional E-value: 8.5e-06
       LRR_6  4 hLteLdLsgNdIgDeG 19
                 Lt+Ld+ +N+Ig eG
  EFC36065.1 51 QLTSLDIHSNQIGAEG 66
                69*************9 PP

  == domain 4  score: 15.8 bits;  conditional E-value: 4.7e-06
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                 Lt+Ld+ +N+Ig eGa+ ++
  EFC36065.1 75 QLTSLDIYSNEIGVEGAKYIS 95
                69***************9885 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.9   0.1   3.6e-11     8e-08       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   17.5   0.3   1.2e-06    0.0026       2      38 ..      51      87 ..      50     101 .. 0.90

  Alignments for each domain:
  == domain 1  score: 31.9 bits;  conditional E-value: 3.6e-11
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsLd++ N++ + + +  + +++L++Ld+ +N++    ++ +s +++L+sLd+ +N++
  EFC36065.1  3 QLTSLDIHYNQIGAEGSKYISEMKSLTSLDIYSNEIGIEGAKYISEMNQLTSLDIHSNQI 62
                7*********************************************************98 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 1.2e-06
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38
                +LtsLd+++N++ + + +  + +++L++Ld+ +N++ 
  EFC36065.1 51 QLTSLDIHSNQIGAEGSKYISEMNQLTSLDIYSNEIG 87
                79********************************985 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   2.3e-07   0.00051       2      36 ..       3      38 ..       2      45 .. 0.82
   2 !   18.2   0.1   1.1e-06    0.0025       2      35 ..      51      85 ..      43     102 .. 0.87

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 2.3e-07
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                +L++Ld++ Nq+   ++  ++ +++L++Ld+ +N  i
  EFC36065.1  3 QLTSLDIHYNQIGAEGSkyISEMKSLTSLDIYSN-EI 38
                69***********777776445*********777.44 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 1.1e-06
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35
                +L++Ld+++Nq+   ++  ++ + +L++Ld+ +N  
  EFC36065.1 51 QLTSLDIHSNQIGAEGSkyISEMNQLTSLDIYSN-E 85
                69***********777776445*********777.3 PP

>> RHH_3  Ribbon-helix-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.31   6.9e+02      13      35 ..       3      25 ..       2      28 .. 0.76
   2 !   11.6   0.0     9e-05       0.2      14      35 ..      28      49 ..      24      49 .. 0.90
   3 !    7.0   0.0    0.0026       5.8      12      35 ..      50      73 ..      48      73 .. 0.92
   4 !   13.8   0.0   1.9e-05     0.043      12      35 ..      74      97 ..      72      97 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.31
       RHH_3 13 laekLkaLSekTrIprSklldeA 35
                ++++L+   ++++ + Sk++ e+
  EFC36065.1  3 QLTSLDIHYNQIGAEGSKYISEM 25
                66677777778888889999886 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 9e-05
       RHH_3 14 aekLkaLSekTrIprSklldeA 35
                +++L+ +S++++I+ +k++ e+
  EFC36065.1 28 LTSLDIYSNEIGIEGAKYISEM 49
                679****************886 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0026
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+  S++++ + Sk++ e+
  EFC36065.1 50 NQLTSLDIHSNQIGAEGSKYISEM 73
                799******************886 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 1.9e-05
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+ +S++++++ +k++ e+
  EFC36065.1 74 NQLTSLDIYSNEIGVEGAKYISEM 97
                899******************886 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0     0.012        28       1      18 [.       3      20 ..       3      25 .. 0.76
   2 ?    5.0   0.0     0.023        51       1      13 [.      27      39 ..      27      49 .. 0.80
   3 ?    5.8   0.0     0.012        28       1      18 [.      51      68 ..      51      73 .. 0.75
   4 ?    5.4   0.0     0.016        37       1      19 [.      75      93 ..      75      97 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.012
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++Ld+ +n+++  ++ 
  EFC36065.1  3 QLTSLDIHYNQIGAEGSK 20
                599*******99655555 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.023
       LRR_1  1 nLrhLdLsnnpll 13
                +L++Ld+ +n ++
  EFC36065.1 27 SLTSLDIYSNEIG 39
                69******99983 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.012
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++Ld+ +n+++  ++ 
  EFC36065.1 51 QLTSLDIHSNQIGAEGSK 68
                599******998655555 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.016
       LRR_1  1 nLrhLdLsnnpllglppns 19
                +L++Ld+ +n ++  ++ +
  EFC36065.1 75 QLTSLDIYSNEIGVEGAKY 93
                599*******997666555 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.2    0.0008       1.8     170     207 ..      17      54 ..      11      62 .. 0.89
   2 !    8.1   0.2   0.00092       2.1     170     206 ..      65     101 ..      59     103 .] 0.92

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0008
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 e  ++++eM++L   + Y+++I  e ++ + e+++l +
  EFC36065.1  17 EGSKYISEMKSLTSLDIYSNEIGIEGAKYISEMNQLTS 54 
                 55799*****************************9976 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00092
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklreleald 206
                 e  ++++eM++L   + Y+++I  e ++ + e+++++
  EFC36065.1  65 EGSKYISEMNQLTSLDIYSNEIGVEGAKYISEMKSIN 101
                 55799*****************************986 PP

>> Nucleic_acid_bd  Putative nucleic acid-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.03        67      70      90 ..       3      23 ..       1      51 [. 0.69
   2 ?    8.3   0.0   0.00085       1.9      69     102 ..      50      81 ..      45     100 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.03
  Nucleic_acid_bd 70 rlrelgilsvQiegeqaiklt 90
                     +l+ l+i   Qi++e+   ++
       EFC36065.1  3 QLTSLDIHYNQIGAEGSKYIS 23
                     899999999999999764444 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00085
  Nucleic_acid_bd  69 prlrelgilsvQiegeqaikltlearvqlpaddi 102
                       +l+ l+i s Qi++e+   +++  ++ql + di
       EFC36065.1  50 NQLTSLDIHSNQIGAEGSKYISE--MNQLTSLDI 81 
                      589************99876666..666666665 PP

>> DUF2634  Protein of unknown function (DUF2634)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.6   3.6e+03      48      61 ..      13      26 ..       8      36 .. 0.61
   2 ?    5.4   0.5    0.0084        19      43      61 ..      32      50 ..      26      73 .. 0.82
   3 ?   -0.7   0.0      0.69   1.5e+03      44      60 ..      57      73 ..      51      79 .. 0.76
   4 ?    5.7   0.1    0.0072        16      43      63 ..      80     100 ..      73     103 .] 0.85

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.6
     DUF2634 48 nYGveledligkky 61
                ++G e +++i++++
  EFC36065.1 13 QIGAEGSKYISEMK 26
                56666666666643 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0084
     DUF2634 43 liYsenYGveledligkky 61
                +iYs+++G+e  ++i+++ 
  EFC36065.1 32 DIYSNEIGIEGAKYISEMN 50
                69************99953 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.69
     DUF2634 44 iYsenYGveledligkk 60
                i s+++G e +++i+++
  EFC36065.1 57 IHSNQIGAEGSKYISEM 73
                77888888888888874 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.0072
     DUF2634  43 liYsenYGveledligkkysk 63 
                 +iYs+++Gve  ++i++++s 
  EFC36065.1  80 DIYSNEIGVEGAKYISEMKSI 100
                 69*************997765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       285  (0.015896); expected 358.6 (0.02)
Passed bias filter:                      179  (0.00998383); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 648.09
//
Query:       EFC36066.1  [L=545]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-08   32.2   0.0     0.0064   16.5   0.0    4.6  4  NHL       NHL repeat
    2.2e-05   24.7   9.9    5.2e-05   23.5   9.9    1.6  1  EGF_2     EGF-like domain
     0.0032   18.0   0.4     0.0032   18.0   0.4    2.7  2  GPS       GPCR proteolysis site, GPS, motif
  ------ inclusion threshold ------
       0.11   12.8   4.2        0.3   11.4   4.2    1.8  1  EGF       EGF-like domain
       0.11   12.6   0.1       0.24   11.6   0.1    1.4  1  DUF1798   Bacterial domain of unknown function (DUF1798)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.058   2.1e+02      11      27 ..      48      64 ..      44      65 .. 0.81
   2 ?    2.0   0.0     0.067   2.4e+02       3      26 ..      96     118 ..      95     119 .. 0.82
   3 !    5.2   0.0    0.0069        25       2      23 ..     154     175 ..     153     179 .. 0.89
   4 !   16.5   0.0   1.8e-06    0.0064       1      26 [.     210     235 ..     210     235 .. 0.96

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.058
                TTTEEEEEECCCTEEEE CS
         NHL 11 snGdiyVaDsenhrvqv 27
                 ++d+y++D  n r+++
  EFC36066.1 48 VDNDLYISDAFNYRIRK 64
                69*******88888875 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.067
                 SEEEEEEETTTEEEEEECCCTEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvq 26 
                 y ++ ++ +nG+++ aD +n+ ++
  EFC36066.1  96 YVWDMRI-QNGELVFADMNNNLIR 118
                 6688889.9********8888776 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0069
                 SSEEEEEEETTTEEEEEECCCT CS
         NHL   2 nyPhGvavdsnGdiyVaDsenh 23 
                  +P +va +++Gd ++a++e h
  EFC36066.1 154 KNPGSVAFLPTGDMIIAETEGH 175
                 5899***************999 PP

  == domain 4  score: 16.5 bits;  conditional E-value: 1.8e-06
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +++P+G++++++G+i+ +D++n+rv+
  EFC36066.1 210 LYQPTGLSILQDGRIIFSDFGNNRVR 235
                 78**********************96 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   9.9   1.4e-08   5.2e-05       6      32 .]     271     296 ..     267     296 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 1.4e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G+C +++ +C+C+sgy+G++C
  EFC36066.1 271 KVCSGNGICSSLN-NCSCSSGYSGNDC 296
                 57********899.8************ PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.9   5.7         5   1.8e+04      17      32 ..     307     321 ..     278     324 .. 0.59
   2 !   18.0   0.4   8.8e-07    0.0032       2      45 .]     434     486 ..     433     486 .. 0.83

  Alignments for each domain:
  == domain 1  score: -5.9 bits;  conditional E-value: 5
         GPS  17 steGCeltesdnknet 32 
                 s+  C+ t+s+n++et
  EFC36066.1 307 SSYVCT-TTSLNTTET 321
                 334455.555566666 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 8.8e-07
         GPS   2 sCvfWdeeneetgsWsteGCel............tesdnknetvCsCnHLtsFAvL 45 
                 +C ++d   e+++ W ++G e              + + + + +C+  HLtsF ++
  EFC36066.1 434 TCMYYD---ESEKVWKSDGVESeiteiilhnladGNVTLTISLTCKTFHLTSFGII 486
                 8****6...5679*******777899999999984444667799*********996 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   4.2   8.4e-05       0.3       5      31 ..     271     294 ..     267     295 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 8.4e-05
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + Cs++G+C ++     +C C++Gy+G+
  EFC36066.1 271 KvCSGNGICSSLN----NCSCSSGYSGN 294
                 46*******5555....**********7 PP

>> DUF1798  Bacterial domain of unknown function (DUF1798)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   6.6e-05      0.24      46      91 ..     401     446 ..     390     453 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.6e-05
                 HHHHHHHHHHS--SSS-HHHHHHHHHHHHHHHHHHHH--S-HHHHH CS
     DUF1798  46 kelalewvkkerpkylheeqieataenleklvvqsFfpktskkrfi 91 
                 +++++++ + e+p +l+ ++++ t+ n+e+l v++ + ++s+k  +
  EFC36066.1 401 SNQKISVQNLEEPISLYFNKVNMTVSNIETLNVTCMYYDESEKVWK 446
                 566677777889*****************************99765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (545 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1144  (0.0638072); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 3310.55
//
Query:       EFC36067.1  [L=230]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (230 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1386.80
//
Query:       EFC36068.1  [L=202]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.1e-11   42.1   1.5    6.7e-10   39.3   1.5    2.1  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
       0.01   15.7   0.3      0.013   15.4   0.3    1.1  1  DUF241    Arabidopsis protein of unknown function
      0.015   14.2   0.1      0.022   13.7   0.1    1.2  1  DUF4507   Domain of unknown function (DUF4507)


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.3   1.5   1.1e-13   6.7e-10       3     114 ..      18     189 ..      16     193 .. 0.86

  Alignments for each domain:
  == domain 1  score: 39.3 bits;  conditional E-value: 1.1e-13
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS......................................SHHHHHHHHHHHHHHHHTSTTST CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkka......................................keqeelkkkakeIyneylapssp 63 
                 e+++  q  r++F+eFl+++ +ee l +++++e++k +                                      ++  +l    k I++e++ ++++
  EFC36068.1  18 EEVMTCQETRNIFKEFLKENMAEEPLLYLDECEKYKVEyaklkekfhglslmvkrsssvgnvsdlgnetsgkewdkNQLTKLFVNLKGIIDEFIVEEAT 116
                 7889999****************************************************************997544445555569************* PP

                 TSSTS-HHHHHHHHHHHCSS.......................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHH CS
         RGS  64 kelnidkklreelekrleke.......................qpsrklfeeaqeevfellekdsypkFlksel 114
                 keln+++    ++ +                               + lfe++   v+  l+ d++p+F++s+l
  EFC36068.1 117 KELNLSSVRQWTIMEWQI-IeammngfeqdssnlelsnnlyrkLDINVLFEKVDLVVMIDLKMDQFPRFIRSNL 189
                 *****9865544443321.13467778999**********997666779***********************87 PP

>> DUF241  Arabidopsis protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   0.3   2.2e-06     0.013      32     146 ..      33     143 ..      16     183 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.2e-06
      DUF241  32 kwveelldgsLrllDvcgttrdallqlkehvqelqsalRRrkggeiesevaaylrsrKkmkKeiakllsslkkmekklassssnkdsellevvevlrev 130
                  + e++ ++ L +lD c++ +   ++lke+ ++l  +++R ++    s++ + ++ +   k +++kl+ +lk++  +  ++     +++l++ + +r+ 
  EFC36068.1  33 FLKENMAEEPLLYLDECEKYKVEYAKLKEKFHGLSLMVKRSSSVGNVSDLGNETSGKEWDKNQLTKLFVNLKGIIDEFIVEE---ATKELNL-SSVRQW 127
                 5668999*********************************995533677777776666667789*******99655544433...2233333.344677 PP

      DUF241 131 eavtvsvlesLlsfls 146
                 + +  +++e++++++ 
  EFC36068.1 128 TIMEWQIIEAMMNGFE 143
                 7777777777777765 PP

>> DUF4507  Domain of unknown function (DUF4507)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   3.7e-06     0.022      38      84 ..      97     148 ..      80     161 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.7e-06
     DUF4507  38 l...dllmelieefiFlerdergk.rrkrlsalqElqLleilceyfqeqe.s 84 
                 +     l+ +i+efi  e +++ + ++ r   + E q++e++++ f++ + +
  EFC36068.1  97 TklfVNLKGIIDEFIVEEATKELNlSSVRQWTIMEWQIIEAMMNGFEQDSsN 148
                 234577899*********99999877889999**************998834 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (202 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1288.28
//
Query:       EFC36069.1  [L=170]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0027   17.5   0.2     0.0061   16.3   0.2    1.6  1  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
     0.0032   16.9   0.0     0.0042   16.6   0.0    1.1  1  DUF5022   Domain of unknown function (DUF5022)


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.2   6.8e-07    0.0061       2      30 .]     135     163 ..     134     163 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 6.8e-07
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                  sv +G+  ++a+tedG  l++GsNs+GQ
  EFC36069.1 135 SSVVMGYTEAIAITEDGFALGCGSNSNGQ 163
                 6788888889******************9 PP

>> DUF5022  Domain of unknown function (DUF5022)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   4.6e-07    0.0042     107     148 ..      57      98 ..      44     119 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 4.6e-07
     DUF5022 107 lprsddkiyytyqGsemvsvkiyydnkksdpkvlkeGeatkd 148
                   r d+ ++yt +  em+  +i y n ks+p  +   ea+++
  EFC36069.1  57 KFRKDQATFYTAKFKEMIKARIAYRNDKSEPTSFSLLEASQA 98 
                 4699***************************98776666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       304  (0.0169558); expected 358.6 (0.02)
Passed bias filter:                      252  (0.0140554); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.30s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 1108.41
//
Query:       EFC36070.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0096   15.5   0.1     0.0096   15.5   0.1    1.2  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   5.4e-07    0.0096       1      45 [.       1      48 [.       1     147 [. 0.71

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 5.4e-07
                   EEEEESTG.......CHHHHTHHHHHHHHHHHHHHC..TTSEEEEEEEBSCTCH CS
                   xxxxxxxx.......xxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxx RF
  Exo_endo_phos  1 ltwNvngq.......aspalgssrrsdrladlltay..daDvlgLQEvdddels 45
                   +++Nvn++              s+   r+++ ++++  + D+++LQE++ +++ 
     EFC36070.1  1 MSFNVNFGgvnydgaL------SYNGQRVLQAMKENvdNVDLICLQETHVGWEI 48
                   79******97655441......456777999998886566*******9998843 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       423  (0.0235931); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.50
# Mc/sec: 1054.36
//
Query:       EFC36071.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.036   13.2   0.0       0.05   12.7   0.0    1.1  1  DUF2264   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF2264  Uncharacterized protein conserved in bacteria (DUF2264)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   2.8e-06      0.05     110     167 ..      93     149 ..      89     167 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2.8e-06
     DUF2264 110 aLllapeqlwekldeeekenlvewLkqlrekempdnNWllFrvlvelaLkkvgeeyde 167
                 aL +  +++ +kl + + +n+ + L ++ +++  ++N+ lF++ +e+aL++   e+ +
  EFC36071.1  93 ALPVHVRAIHKKLLAITEDNIFRILLDIIHTDSTQKNFSLFKMAIECALEN-PSEFAP 149
                 667777889999999**********************************98.344444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       407  (0.0227007); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 1239.98
//
Query:       EFC36072.1  [L=359]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.072   12.6   0.3       0.14   11.7   0.3    1.4  1  Filo_VP24  Filovirus membrane-associated protein VP24


Domain annotation for each model (and alignments):
>> Filo_VP24  Filovirus membrane-associated protein VP24
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.3   7.8e-06      0.14      65     163 ..     114     219 ..     103     232 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7.8e-06
                 SSCCCHHHHHHTHHHHS-TTEEE--HHHHHHHHHHHHCCHCCCCTTS-HHHHHHHHHHHHHHHH---SB--...--CCCHHCH--HHHH....HHHHHH CS
   Filo_VP24  65 vvpewsqtrnlfshlfknpkstiiepllalrvllavalkdqeldqslieglasilgllsewlllevtsain...irtqllkiqlsldml....kllran 156
                 v+    +  ++    +k p+s+i  p +al++  +v+ +   +d+ + + l++++++ ++  ll + + +    +  ++l+     d+l     l+r n
  EFC36072.1 114 VILSETMRADMIKRALKLPNSSIDTPNYALKLSACVGCQTVVIDKEIKPLLRNLINIETKDSLLSNRACVAyaaVYLNKLDLETVFDLLihpqYLVRQN 212
                 44555566678888999*************************************999776666666554440013334444444444442222356666 PP

                 HHHHHHH CS
   Filo_VP24 157 vkkfink 163
                 +k +i k
  EFC36072.1 213 IKAWIFK 219
                 6666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (359 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       830  (0.0462937); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 2224.74
//
Query:       EFC36073.1  [L=516]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.7e-22   78.9   0.6    6.6e-22   78.1   0.6    1.3  1  Pkinase          Protein kinase domain
    1.8e-09   37.2   0.0    2.9e-09   36.6   0.0    1.4  1  Pkinase_Tyr      Protein tyrosine kinase
      0.008   15.2   1.7      0.013   14.5   1.7    1.3  1  Pox_ser-thr_kin  Poxvirus serine/threonine protein kinase
  ------ inclusion threshold ------
      0.014   14.2   0.2      0.014   14.2   0.2    1.6  2  Pkinase_fungal   Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.1   0.6   1.5e-25   6.6e-22      89     259 ..     265     452 ..     231     454 .. 0.79

  Alignments for each domain:
  == domain 1  score: 78.1 bits;  conditional E-value: 1.5e-25
                 HHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET..............TTE.......EEE-SGTTSEESSSSCS.........BCTT CS
     Pkinase  89 lerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide..............kge.......lKitDFGlakelesssk.........ltsf 157
                      + s++e  +i++q+l  ++++Hs++iiH D+Kp+Ni+i e              + e        K +DF lak+++ +            +s 
  EFC36073.1 265 N----KRSHQEKLHIISQLLLEIDHIHSRKIIHNDIKPSNIIILEedhlkslviketdaH-EkkgpncfCKFIDFELAKRFDIEDGdtcklanlwIQST 358
                 3....346777789*****************************97466666666666551.05677888***********99887789*********** PP

                 TSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTT CS
     Pkinase 158 vgtseYlAPEvl..keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRlt 254
                  gts Y APE    ++n + +k+D++slG++++el+ ++ + +     ++ e+ +d++ +++ i        + + +  + + d+lk++++ ++k+R+t
  EFC36073.1 359 AGTSSYNAPEKEstGKNFIHPKTDIYSLGLVFIELILENDIDK-----KRLENTADEIWQTISIK-----CHELEPNKGSMLFDMLKQMVAIERKERPT 447
                 *********9987455666****************88888877.....44555666644444443.....3345556688999**************** PP

                 HHHHH CS
     Pkinase 255 aeell 259
                  +e+l
  EFC36073.1 448 TRECL 452
                 *9997 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6   0.0   6.5e-13   2.9e-09      98     257 ..     265     453 ..     169     455 .. 0.81

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 6.5e-13
                  TTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE....................TTEEEE-STTTHEETTTSSEE......EETTSSTSGG CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse....................nkvvkisDfGLardiekddey......vkkeeaklpv 169
                  +k + +++l+++ q+   +++++s+k++H d+   N+++ e                    n ++k  Df La++   +d           +++    
   EFC36073.1 265 NKRSHQEKLHIISQLLLEIDHIHSRKIIHNDIKPSNIIILEedhlkslviketdahekkgpNCFCKFIDFELAKRFDIEDGDtcklanLWIQSTAGTS 362
                  566788999****************************99988******************999***********984333331222222235666778 PP

                  GGS-HHHHHHSE..EEHHHHHHHHHHHHHHHHTTSSGTTTTS..HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 170 kWmapEslkekk..ftsksDvWsfGvllwEiftlgespypgl..kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselve 257
                   + apE  +++k  +  k+D++s G + +E++   +   ++l  ++ e+ ++++ + +  +p +  + l +++k+  + + +eRpt +e++ 
   EFC36073.1 363 SYNAPEKESTGKnfIHPKTDIYSLGLVFIELILENDIDKKRLenTADEIWQTISIKCHELEP-NKGSMLFDMLKQMVAIERKERPTTRECLA 453
                  89999876666655999****************99999998852334566666555544444.46889******************999976 PP

>> Pox_ser-thr_kin  Poxvirus serine/threonine protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   1.7   2.9e-06     0.013     282     348 ..     275     341 ..     217     354 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 2.9e-06
  Pox_ser-thr_kin 282 LqiaLLyikiyelpdcenflhvDlkPdniLifds..kekliikvkerkyvfkepvklaLnDfDfsrvae 348
                      + i+ L++ i      ++ +h+D+kP ni+i ++   + l ik  +++     +  +++ Df++++  +
       EFC36073.1 275 I-ISQLLLEIDHI-HSRKIIHNDIKPSNIIILEEdhLKSLVIKETDAHEKKGPNCFCKFIDFELAKRFD 341
                      3.67788999555.566789************9844568888888888877778888889998887555 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.2   3.2e-06     0.014     294     366 ..     256     344 ..     163     383 .. 0.78
   2 ?   -3.1   0.1      0.54   2.4e+03     257     281 ..     480     504 ..     434     510 .. 0.61

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 3.2e-06
  Pkinase_fungal 294 pvGkpiekae..spkellealrDaIkghrsLflkagiLHrDiSenNilit...............dskkegerkglLiDLDlakelsdds 366
                      +G ++++++  s +e l+ + + +      +   +i+H+Di   Ni+i+                +kk +++    iD++lak  + ++
      EFC36073.1 256 IAGDELNTFNkrSHQEKLHIISQLLLEIDHIH-SRKIIHNDIKPSNIIILeedhlkslviketdaHEKKGPNCFCKFIDFELAKRFDIED 344
                     55666666541245667777777777777888.99***************6666666666665322233377777899***999988544 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.54
  Pkinase_fungal 257 kksesskkvekrsvdssvstskrsr 281
                     +++++++k +++++++s+ ++kr+r
      EFC36073.1 480 NPEKNESKLSTTETNNSTYEKKRKR 504
                     2333333444445555554444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (516 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       787  (0.0438954); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3015.42
//
Query:       EFC36074.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1015  (0.0566122); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 2012.66
//
Query:       EFC36075.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      2e-12   48.1   1.4    3.2e-12   47.4   1.4    1.4  1  Metallophos    Calcineurin-like phosphoesterase
    1.6e-09   38.2   0.0    4.1e-09   36.9   0.0    1.6  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.4   1.4   3.6e-16   3.2e-12       1     204 []      56     245 ..      56     245 .. 0.73

  Alignments for each domain:
  == domain 1  score: 47.4 bits;  conditional E-value: 3.6e-16
                  EEEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSSHHHHHHHHHHHHHHHH....TSEEEEEC-TTSCHHHHHHHHHHHHHHHHHH CS
  Metallophos   1 lrilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrgdlekellellaalvky....pipvylllGNHegfeeellnkygylgifsep 94 
                  +++++i+D+H      ++++ ++l          d++l++GD++++g + + +  ++++l+k+     + ++++ GNHe ++ ++    +++++f e 
   EFC36075.1  56 MKFVLISDTH------CMHEMVDLP-------AGDVLLHCGDFTNTGLFTE-VDTFFEYLIKQcdgvFKYIIMIVGNHE-WSPDIIVYPRFQKYFREE 138
                  7999******......777777755.......78*************5555.6666666666544432235********.999999999999999777 PP

                  HEHHHCEEETSEEEEEETTEEEEEEEESECEEETHHHHHHHHHHHSCHHHHCC...HHHHHHHHHHTTCSEEEEEESSESS......CSSSCSCCHHH CS
  Metallophos  95 wrsdaevfnnlplaslgsgslkvlllhGgspellvsldklgslnleleapepg...dewlkdlekrekadwvivlgHsply......rgsgylfgdea 183
                  + + + + +++ l +      +++ ++++         k++++ ++ +++ p    +     ++   ++d++i+++H p        +++g + g+e+
   EFC36075.1 139 KSKSTLKSQYYLLLDESV---TIVDDNNH-------SIKIHGVRYRGNWAPPLfckK-----TSFNIPNDIDILMTHFPCCkfnmdrTSNGSSRGSEE 221
                  766655555555555222...45555555.......344455556666666444442.....33334667**********9***************** PP

                  HHHHHHHTT...ESEEEEESSSSE CS
  Metallophos 184 ledllkkyg...vdlvisGHtHvy 204
                  l +ll+ +    +++ ++GH H++
   EFC36075.1 222 LTTLLDSNHftnLKVHCFGHNHCP 245
                  **9999999999**********86 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.9   0.0   4.5e-13   4.1e-09       1     148 [.      56     268 ..      56     275 .. 0.71

  Alignments for each domain:
  == domain 1  score: 36.9 bits;  conditional E-value: 4.5e-13
  Metallophos_2   1 MklaiiSDlHsnldaleavlealkevgvdaiihaGDl.eeeepevleellela.........pvlaVrGNnD........................ 62 
                    Mk+++iSD+H  +++   +     +   d ++h+GD+ +++ ++ +++++e +          ++++ GN++                        
     EFC36075.1  56 MKFVLISDTH-CMHEMVDL----PAG--DVLLHCGDFtNTGLFTEVDTFFEYLikqcdgvfkYIIMIVGNHEwspdiivyprfqkyfreekskstl 144
                    **********.33333333....344..89*******99999999999999889999***999************999998886666555555555 PP

  Metallophos_2  63 .........eev.veedvlreaaelgtdl.........peeaelel...agekvlliHgdpl.............gvkdalaellkeaeegsd.vv 122
                             e v +++d  ++ + +g ++            ++ ++   ++ ++l++H                 +++++l+ ll+++  ++  v 
     EFC36075.1 145 ksqyyllldESVtIVDDNNHSIKIHGVRYrgnwapplfC--KKTSFnipNDIDILMTHFP-CckfnmdrtsngssRGSEELTTLLDSNHFTNLkVH 237
                    555555554222344444444444444445555553331..2222222355557777775.369*******99999999999999985444446** PP

  Metallophos_2 123 vcGHtHvp.....evekeggvlvvnPGsvge 148
                    ++GH H p       eke +++++n+ sv +
     EFC36075.1 238 CFGHNHCPkargfAYEKESDRMYINAISVIG 268
                    ********8888878888899*****99966 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       406  (0.0226449); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.34s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1742.49
//
Query:       EFC36076.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.028   14.5   0.3      0.098   12.7   0.3    2.2  1  AAA_lid_5  Midasin AAA lid domain


Domain annotation for each model (and alignments):
>> AAA_lid_5  Midasin AAA lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.3   5.5e-06     0.098      73     103 ..     106     170 ..       6     173 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.5e-06
   AAA_lid_5  73 r..................................alyeGfsmsFltqLdsesrkkveklirkil 103
                                                    +l eG+ + Fl q+++ s++++e+ + +i+
  EFC36076.1 106 HfifkalmkhkseamkaltdchsdgyfkhqrlfttILSEGYAFLFLKQIQEVSYSMMEESALRIT 170
                 05555555555555555555555666666666666***********************9988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       655  (0.036533); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.27s 00:00:00.70 Elapsed: 00:00:00.44
# Mc/sec: 1215.90
//
Query:       EFC36077.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.5e-29  102.4   0.0    5.3e-29  101.3   0.0    1.5  1  DUF676        Putative serine esterase (DUF676)
    7.5e-06   25.9   0.0    2.2e-05   24.3   0.0    1.8  2  Lipase_3      Lipase (class 3)
    0.00014   21.7   0.2    0.00029   20.6   0.0    1.7  2  PGAP1         PGAP1-like protein
     0.0058   16.5   0.0      0.013   15.4   0.0    1.8  1  Palm_thioest  Palmitoyl protein thioesterase
  ------ inclusion threshold ------
       0.12   12.6   0.2        3.6    7.8   0.1    2.6  3  DUF432        Protein of unknown function (DUF432)


Domain annotation for each model (and alignments):
>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.3   0.0   1.5e-32   5.3e-29       6     213 ..       4     216 ..       2     224 .. 0.86

  Alignments for each domain:
  == domain 1  score: 101.3 bits;  conditional E-value: 1.5e-32
      DUF676   6 hLvVlvHGlqgnsaDlelikeqleki........keklpeekieflmsennesktfkgidvlgerlaeevlevvkkkkdk.......nkkiSfvghSlG 89 
                 h +Vl HG +g ++D+e++++ +++         ++ lp++++  l  + n+++t++g+ v g+r+a+e++e+++k+          + k S++ghSlG
  EFC36077.1   4 HFIVLSHGNNGQHEDMEYLQHDIQLEfhkkypilDSILPDDQLFALRPSSNSKDTHHGVAVGGKRMAQEIIEYFRKEILPkfternkKVKFSLIGHSLG 102
                 99*****************99988777777888888899************************************998777888877889********* PP

      DUF676  90 gliaraaiaklkekemtlkeaikglepvtfitlasPhLGvlyssksl.inlglalleklkkslsmeqlgltGrdLflkddkdeknsllykllkdekdlk 187
                 gl  r+a  +l ++ +  +e+ k  ep+ ++t+ sPhLG+   s+     l  ++++ ++++ + + lg tG++L l        +ll+++++ e+  k
  EFC36077.1 103 GLYCRYAAYVLMNEYE--DEFSKYFEPIGLTTICSPHLGSKRTSSGGwTDLYGNVVSTIANTYVGHFLGDTGKQLALS------DPLLMEMSEPES--K 191
                 *******987775544..5566899**************97766664155667899*******************999......79*****66665..* PP

      DUF676 188 liealklFkrrvlyanvvndrivpla 213
                 +i+a + Fk  +l++++ ++ i + +
  EFC36077.1 192 FISAWNSFKFKTLIGST-HYDISVPH 216
                 ***************88.55555444 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   0.0   6.3e-09   2.2e-05      41     112 ..      68     143 ..      39     158 .. 0.80
   2 ?   -3.6   0.0       2.6   9.2e+03      65      73 ..     235     243 ..     231     243 .. 0.81

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 6.3e-09
                 HHHHS-HHHHHHHH.HHHHHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS....---EEEEEES----B-HHH CS
    Lipase_3  41 eayeeslreqvlke.lkrllekypeysivvtGHSLGgalAlLaaldlvengene....kkkvtvvtfGqPrvgnkef 112
                 ++++  + e ++ke l +  e+++++++ + GHSLGg     aa++l +++e e     +++++ t+ +P  g+k+ 
  EFC36077.1  68 RMAQ-EIIEYFRKEiLPKFTERNKKVKFSLIGHSLGGLYCRYAAYVLMNEYEDEfskyFEPIGLTTICSPHLGSKRT 143
                 4444.44455555505569999*****************************9999998899***********99875 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 2.6
                 EEEEEEEET CS
    Lipase_3  65 ysivvtGHS 73 
                 +++ ++GHS
  EFC36077.1 235 IEFSIVGHS 243
                 6899****9 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0     8e-08   0.00029       8     157 ..       7     165 ..       4     201 .. 0.74
   2 ?   -4.1   0.1       2.9     1e+04      43      58 ..     257     272 ..     250     276 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 8e-08
       PGAP1   8 lFvpGnagsykqvrslAseaaeayqe....lrkllknqnkkeldfftvdfneel.saldGrtlldqaeylndaIkyIlslysssekeptsviliGHSmG 101
                 ++ +Gn g ++++  l  + + ++ +    l++ l+ ++ + l+  +   +  + +a+ G+ +   +e +++  k+Il  + ++++++ +  liGHS+G
  EFC36077.1   7 VLSHGNNGQHEDMEYLQHDIQLEFHKkypiLDSILPDDQLFALRPSSNSKDTHHgVAVGGKRMA--QEIIEYFRKEILPKF-TERNKKVKFSLIGHSLG 102
                 5668888888888888877766666655556666666666666655555554442577777777..788999999999999.888899999******** PP

       PGAP1 102 Givaraa.ltlknyikqsvnt......iltlasPhalpplsfdkdilklyervnefwkkelee 157
                 G+  r a  +l n  +++ ++      + t+ sPh  +  +  +  ++ly +v +   + ++ 
  EFC36077.1 103 GLYCRYAaYVLMNEYEDEFSKyfepigLTTICSPHLGSKRTSSGGWTDLYGNVVSTIANTYVG 165
                 ****9652445553344444312222267999******************9999887776655 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 2.9
       PGAP1  43 kkeldfftvdfneels 58 
                  keldf   df+e + 
  EFC36077.1 257 DKELDFQVEDFDESIE 272
                 4679999999999875 PP

>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   3.6e-06     0.013      51     109 ..      69     149 ..       6     303 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3.6e-06
  Palm_thioest  51 lndqveavckk........lelangfhaiGfSQGglflRaliercddkkn........vrnlislggpqaGvfg......l 109
                   + +++ ++++k         +++ +f +iG+S Ggl +R  +    ++ +           l ++++p+ G          
    EFC36077.1  69 MAQEIIEYFRKeilpkfteRNKKVKFSLIGHSLGGLYCRYAAYVLMNEYEdefskyfePIGLTTICSPHLGSKRtssggwT 149
                   333333333334555566657899***************876554333224566887756788999999998774444330 PP

>> DUF432  Protein of unknown function (DUF432)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.1     0.001       3.6      57      84 ..      90     117 ..      78     127 .. 0.83
   2 ?   -3.5   0.0       3.1   1.1e+04      33      54 ..     232     254 ..     221     258 .. 0.59
   3 ?    1.7   0.0     0.078   2.8e+02      88     122 ..     276     310 ..     266     311 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.001
      DUF432  57 skkkYaLYGspesGviaryvksevysep 84 
                 +k+k++L G+   G  +ry+   +++e 
  EFC36077.1  90 KKVKFSLIGHSLGGLYCRYAAYVLMNEY 117
                 789****************987777665 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 3.1
      DUF432  33 kvpveigvf.ikskkeveliDvf 54 
                 k p+e +++  +  ++ +  D+f
  EFC36077.1 232 KGPIEFSIVgHSGFDSDNYSDIF 254
                 44677777744455555555555 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.078
      DUF432  88 dpleeavveleikNetdevvevskivfdalglkly 122
                 d+ +e +++ ++ N+ ++ v+ ++i ++ ++ ++y
  EFC36077.1 276 DSSNENLISTKMLNNLQKHVNCRRIHIQFSYPSFY 310
                 56678899999*****************9999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       518  (0.0288917); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 2102.06
//
Query:       EFC36078.1  [L=143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      266  (0.0148363); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.30s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 927.91
//
Query:       EFC36079.1  [L=177]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-22   78.6   0.4    6.1e-22   77.7   0.4    1.5  1  CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) a
    1.4e-06   28.7   0.1    2.3e-06   28.0   0.1    1.3  1  Histone        Core histone H2A/H2B/H3/H4
     0.0047   17.0   0.0     0.0073   16.4   0.0    1.3  1  CENP-T_C       Centromere kinetochore component CENP-T histon
     0.0098   15.7   1.9     0.0098   15.7   1.9    2.1  2  PAN_3          PAN-like domain


Domain annotation for each model (and alignments):
>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.7   0.4   1.4e-25   6.1e-22       2      65 .]      84     151 ..      83     151 .. 0.91

  Alignments for each domain:
  == domain 1  score: 77.7 bits;  conditional E-value: 1.4e-25
                    XXXHHHHHHHHHCC.TTXS-...B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF   2 eLPiarvkkImksd.pdark...iakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65 
                     LP a++++Imk++ +  +k   i+k+Ake+++ecv+efi ++++eA+++c +ekrKt+++e+++ A+
     EFC36079.1  84 LLPYANIERIMKKTvEMFNKsakISKEAKECMQECVTEFICFVTGEASDLCVEEKRKTVAGEDVLNAL 151
                    59**********99765444455*****************************************9986 PP

>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.1     5e-10   2.3e-06      57     128 ..      80     151 ..      78     154 .. 0.92

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 5e-10
                 XXSXXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXSEEXHHHHHHHH CS
     Histone  57 stdlliqklpfaRvvreivksekedlrisaeavlalqealEallvelfeeAnllakhaKRvTitpkDiqlAr 128
                 + d+l + + ++R++++ v+ + ++ +is+ea +++qe +  ++  ++ eA+ l+ + KR+T+  +D+  A+
  EFC36079.1  80 EQDRLLPYANIERIMKKTVEMFNKSAKISKEAKECMQECVTEFICFVTGEASDLCVEEKRKTVAGEDVLNAL 151
                 4566677799*********************************************************98775 PP

>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   1.6e-06    0.0073       4      73 ..      81     150 ..      78     156 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.6e-06
    CENP-T_C   4 evpslPaavvkklakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilL 73 
                 +   lP a + ++ k+  +   ++ak++kea + ++++  +f+  v+ +        +RKt+  +Dv+  
  EFC36079.1  81 QDRLLPYANIERIMKKTVEMFNKSAKISKEAKECMQECVTEFICFVTGEASDLCVEEKRKTVAGEDVLNA 150
                 45569************99999********************************************9865 PP

>> PAN_3  PAN-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   1.9   2.2e-06    0.0098       8      46 ..      98     135 ..      93     136 .. 0.86
   2 ?   -2.0   2.0      0.72   3.2e+03      34      49 ..     159     173 ..     156     174 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2.2e-06
       PAN_3   8 pedlystssttseswddCvqkCledstCilayknsenCt 46 
                 +e  ++ s ++s++ ++C+q+C  +  C++  + s+ C+
  EFC36079.1  98 VEM-FNKSAKISKEAKECMQECVTEFICFVTGEASDLCV 135
                 344.59999*********************999998885 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.72
       PAN_3  34 tCilayknsenCtlfe 49 
                 +C   y+ +e+C+++e
  EFC36079.1 159 YCKFLYW-DEYCVNCE 173
                 6777788.79999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1040  (0.0580066); expected 358.6 (0.02)
Passed bias filter:                      563  (0.0314016); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.37u 0.28s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 1333.96
//
Query:       EFC36080.1  [L=591]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (591 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       709  (0.0395449); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3455.52
//
Query:       EFC36081.1  [L=365]
Description: hypothetical protein NAEGRDRAFT_82302 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
          2    9.1  11.9        2.4    8.8   1.4    2.2  2  Pex14_N   Peroxisomal membrane anchor protein (Pex14p) conser


Domain annotation for each model (and alignments):
>> Pex14_N  Peroxisomal membrane anchor protein (Pex14p) conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   1.4   0.00014       2.4      62     150 ..      25     115 ..       9     119 .. 0.54
   2 ?    5.3   3.3    0.0016        29      67     111 ..     267     309 ..     236     321 .. 0.40

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00014
     Pex14_N  62 as..eqaqeesasssatpqpqaasqtsqsspspsppaqqqqqqy...rpPivtypefltkppkppppPlr.....twrdllitatalaglgaglyglsk 150
                 ++  +q++++++ ++ t+ pq+++q++ ++ ++++ +++++++     + +  y        +    P+      +++++l+  +++  + ++l ++s+
  EFC36081.1  25 TQiiTQNTTTTQLAAVTTVPQQQQQQQITTFNNNNRYKENENNIeynLSSQSSY--------NYRNGPKLmnrieSTSKWLFYSMIICIMVYLLQSISQ 115
                 223344444444455555555555555555555555555444443343333333........2223333344467899999999999988888877766 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0016
     Pex14_N  67 qeesasssatpqpqaasqtsqsspspsppaqqqqqqyrpPivtyp 111
                 +++++s s+++  q +  +s++s+++s+ +   ++++  P+++++
  EFC36081.1 267 NNNRNSRSNSNAIQRERANSNQSNNSSSRSR--ANSMDYPYQQQQ 309
                 1111111111111111111111111111111..111111222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (365 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1982  (0.110547); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2147.52
//
Query:       EFC36082.1  [L=854]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-43  148.8  27.1    2.2e-43  148.8  27.1    3.0  3  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t
    1.7e-10   40.5  11.5    7.3e-10   38.4  11.5    2.2  1  PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
    2.3e-09   37.9   0.0    3.3e-09   37.3   0.0    1.3  1  Hydrolase        haloacid dehalogenase-like hydrolase
    3.8e-08   33.3   0.4    3.1e-06   27.2   0.1    3.0  3  Cation_ATPase    Cation transport ATPase (P-type)
    4.4e-06   26.4   0.5    4.4e-06   26.4   0.5    2.5  3  E1-E2_ATPase     E1-E2 ATPase
     0.0053   16.5   0.1     0.0053   16.5   0.1    3.6  5  Hydrolase_3      haloacid dehalogenase-like hydrolase


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   4.4       2.2   6.5e+03      74     224 ..      21      37 ..       2      84 .. 0.40
   2 !   11.9   1.7   4.8e-05      0.14     118     201 ..     175     277 ..     160     304 .. 0.67
   3 !  148.8  27.1   7.4e-47   2.2e-43       2     248 ..     619     847 ..     618     848 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.2
  PhoLip_ATPase_C  74 ftslpvivlgifdqdvsaelllkyPelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnl 167
                      ft+lp++                                                                                       
       EFC36082.1  21 FTFLPLV--------------------------------------------------------------------------------------- 27 
                      1111111....................................................................................... PP

  PhoLip_ATPase_C 168 kvaletktwtliliililgsillyflflllyssllpsssefygvleelfsspsfwlv 224
                                                   l+++                   +f++ 
       EFC36082.1  28 -----------------------------LFEQ------------------FKFFFN 37 
                      .............................2222..................111111 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 4.8e-05
  PhoLip_ATPase_C 118 wileglyqsliifflsylv..lddssfs..........dgktndlqlfgtlvftalvlvvnlkval.etk...twtliliililgsillyflfl 195
                      w    + +++ii +++y+   +   s s          ++ +++l++++ + f+ +v++  ++val +++   ++t++ +il++ si+ + l +
       EFC36082.1 175 WANTVVATGTIIALVIYTGreT--RS-SlnasqprskvGKLDQELNTISKFLFILMVIISIFMVALkQFQglwYITIFRFILLFSSIIPISLRV 265
                      4444445555555554444321..11.12345566778999*************************4444766777777777777887666555 PP

  PhoLip_ATPase_C 196 ......llyssl 201
                            ++ys +
       EFC36082.1 266 nldmgkTVYSFF 277
                      444444355544 PP

  == domain 3  score: 148.8 bits;  conditional E-value: 7.4e-47
  PhoLip_ATPase_C   2 raSDyaiaqFrfLkrLLlvhGrwsyrRisklilyffyKnvvftlvqfwfqfyngfsgqslyeswlltlynllftslpvivlgifdqdvsaelll 95 
                       a+D++i+qF++ ++L+l+hGr+sy+R + l ++++++ ++++++q++f+ + +fs+  ++ +wll+ y + +t + v+ l i+d+dv+ +++ 
       EFC36082.1 619 LAADFSINQFSYCTDLILWHGRNSYKRSAALSQFIIHRGLIISVIQAIFSSMFYFSTIAIFTGWLLVGYATYYTNFSVFSL-ILDEDVKRSTVY 711
                      69*****************************************************************************99.************ PP

  PhoLip_ATPase_C  96 kyPelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvaletk.twtliliililgsi 188
                       +PelYk++qk++ +++ktfl+w+l+++yq+ ii++l++++++         n++  ++t++ftal+l+  ++v +e++  ++ ++i++ ++si
       EFC36082.1 712 LFPELYKELQKGRVLSFKTFLIWCLKATYQGGIIMILAIFLFE---------NNFLRIQTISFTALILTEVVMVSIEVHrKFNPLIILSEILSI 796
                      *****************************************97.........5699********************98868899********** PP

  PhoLip_ATPase_C 189 llyflflllyssllpsssefygvleelfsspsfwlvlllvvvvallpdllikvlkrtffp 248
                       +y+ +++l+ s++         +  ++ +  fw+  ++++++++ +  ++k++ ++++p
       EFC36082.1 797 SIYIGSMFLLPSYF---------DLPFIMTFDFWWKSIVITIASTSVVAIFKIIYSRINP 847
                      **********9964.........46778899*********************99999887 PP

>> PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.4  11.5   2.4e-13   7.3e-10      24      65 ..      18      59 ..      16      61 .. 0.93

  Alignments for each domain:
  == domain 1  score: 38.4 bits;  conditional E-value: 2.4e-13
  PhoLip_ATPase_N 24 YtlltFlpknLfeqFrrvaNlYFLviailqliPqisplspvt 65
                     Y+l+tFlp++LfeqF+ + NlYFL++a+ q+iPq+++   +t
       EFC36082.1 18 YNLFTFLPLVLFEQFKFFFNLYFLIVALSQIIPQLQVGFLFT 59
                     **********************************99876666 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.3   0.0   1.1e-12   3.3e-09     103     210 .]     460     604 ..     343     604 .. 0.72

  Alignments for each domain:
  == domain 1  score: 37.3 bits;  conditional E-value: 1.1e-12
                 H..............................TTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEH........HHHHHHHHHTTGGGESEE CS
                 x..............................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxxxxxx RF
   Hydrolase 103 l..............................qaralavftiadplkvkpeaaeavasLkaagievvlltgdnp........etaeraanqlGddyfdav 163
                 +                              + ++ ++  ++d   + + + + +++L+ agi++++ltgd           t + a+++lG d+f  +
  EFC36082.1 460 EfineykkatslindriieidriknkyldsgDLNIIGISGVEDL--LQENVQQSLEQLRNAGIKIWMLTGDKVetaicingDTLQIALDKLG-DKFIKI 555
                 26666666666666666666666666665555566777777788..889999*********************4444444444444444455.777444 PP

                 EEHHCES.STTTSHHHHHHHHHHHT.STGGGEEEEESSHHHHHHHHHTT CS
                 xxxxxxx.xxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 164 iasdiet.vakpspegkvaaireLq.gkpeevamVGDgvnDaaalaaAg 210
                  ++ +++ +   sp +k +++   +    +++a++GDg nD++++ +A+
  EFC36082.1 556 ACKATSViCCRCSPTQKAQVVSLVKkLTRKQTAAIGDGGNDVSMILNAN 604
                 4444444588889999999999997678999*************98885 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       2.5   7.5e+03      36      70 ..     109     143 ..      92     147 .. 0.77
   2 !   27.2   0.1     1e-09   3.1e-06       2      67 ..     327     412 ..     326     425 .. 0.74
   3 ?    2.7   0.0     0.045   1.3e+02      11      45 ..     517     551 ..     506     577 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.5
  Cation_ATPase  36 gldteelreetkkvqeipFnssrKrmsvvlklepe 70 
                    g+  ++lr+  +  q++  n+ rK+ + ++ ++p+
     EFC36082.1 109 GETDQKLRHAIPTTQKLHLNQLRKIIANLYIEKPK 143
                    56678899999999999999999998887766655 PP

  == domain 2  score: 27.2 bits;  conditional E-value: 1e-09
  Cation_ATPase   2 lcNsaaf......sensekdevkllG.nktEsALlvlaekl.............gldteelreetkkvqeipFnssrKrmsvvlkl 67 
                    lc++ +       + n+ ++++++ G +++E+AL+++ae+                ++++  e++++++++pF+ss Krm +++  
     EFC36082.1 327 LCHNVTPiiqsnnNMNNMNNKREYQGsSPDEIALVKFAEQSglilenrtltqmtLRNPNNEFENYEILNIFPFTSSSKRMEIIYYC 412
                    56666656666664455555555555279************99999996666665555666666****************999865 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.045
  Cation_ATPase  11 nsekdevkllGnktEsALlvlaeklgldteelree 45 
                    n+  + + l+G+k E+A+    + l++  ++l ++
     EFC36082.1 517 NAGIKIWMLTGDKVETAICINGDTLQIALDKLGDK 551
                    66677899**********99888887777766555 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.2   2.4         6   1.8e+04     123     160 ..      12      50 ..       8      67 .. 0.63
   2 !   26.4   0.5   1.5e-09   4.4e-06      67     165 ..     171     265 ..     154     272 .. 0.89
   3 ?   -5.3   1.3         6   1.8e+04     120     142 ..     665     687 ..     659     699 .. 0.53

  Alignments for each domain:
  == domain 1  score: -5.2 bits;  conditional E-value: 6
                   HHHHHHHHHHHHHS-STTTSSTT.HHHHHHHHHHHHHS- CS
  E1-E2_ATPase 123 vpvvlliallvflialllgksla.eallralallvaaiP 160
                   v vvl+  l++fl ++l +++ + + l++ ++ l  +iP
    EFC36082.1  12 VQVVLVYNLFTFLPLVLFEQFKFfFNLYFLIVALSQIIP 50 
                   444555555555544444444446777777777766666 PP

  == domain 2  score: 26.4 bits;  conditional E-value: 1.5e-09
                   TTEE-TT-EEEE-EEEEEEEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHHHS-TTH CS
  E1-E2_ATPase  67 gdmvfsGtvvvsgeakavVtatgedtelgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgkslaeallralallvaaiPcaL 163
                   ++++ + tvv  g+++a V+ tg++t+ +     +++++sk  +l ++l+ ++k+l++++++i+++++++  + g +   +++r++ l+ ++iP+ L
    EFC36082.1 171 ENTLWANTVVATGTIIALVIYTGRETRSSL---NASQPRSKVGKLDQELNTISKFLFILMVIISIFMVALKQFQGLWY-ITIFRFILLFSSIIPISL 263
                   79999*********************8664...56677889************************9999998888887.99999**********999 PP

                   HH CS
  E1-E2_ATPase 164 pl 165
                    +
    EFC36082.1 264 RV 265
                   76 PP

  == domain 3  score: -5.3 bits;  conditional E-value: 6
                   HHHHHHHHHHHHHHHHS-STTTS CS
  E1-E2_ATPase 120 kvlvpvvlliallvflialllgk 142
                   ++++ +  + ++++f  +ll+g 
    EFC36082.1 665 AIFSSMFYFSTIAIFTGWLLVGY 687
                   44555555555555555555443 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       1.6   4.8e+03      88     153 ..      77     145 ..      68     179 .. 0.46
   2 ?    0.2   1.8      0.17     5e+02     113     176 ..     292     355 ..     270     362 .. 0.62
   3 ?   -1.6   3.6      0.61   1.8e+03      76     142 ..     310     393 ..     297     471 .. 0.57
   4 ?    0.2   0.0      0.17     5e+02      16      44 ..     504     532 ..     500     545 .. 0.84
   5 !   16.5   0.1   1.8e-06    0.0053     200     226 ..     581     607 ..     568     626 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.6
                  HHHHHHTT....CEEEEEESSEEEESTT............THHHHHHHHHCHCTCEEEESHHHHHCHCSESEEEEES-HHH CS
  Hydrolase_3  88 ikllkenn....veillytedkvyvlnk...........eksekkkkeeektkkkkeeidseeeledeeiakililkdkek 153
                  ++ lk ++     + +ly+++++  ++            ++  +++++ + ++  k + +              i k k++
   EFC36082.1  77 YDDLKRYKrdleSNSQLYNKSGASFIRTdqldgetdqklRHAIPTTQKLHLNQLRKIIANLY------------IEKPKKD 145
                  44444443332255555555555555552222222222222222222222222222222222............3333333 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.17
                  THHHHHHHHHCHCTCEEEESHHHHHCHCSESEEE.EES-HHHHHHHHHHHHHHCTTTEEEEEEST CS
  Hydrolase_3 113 ksekkkkeeektkkkkeeidseeeledeeiakil.ilkdkekldelekelksklnklltitsssk 176
                  ++  ++ +e+ t+ + ++++++++++ +e++k l ++++ + + + ++++++ +nk  +++ ss+
   EFC36082.1 292 EDGFEQVKEHVTNCYINNSNNSNDNQIKEFIKALaLCHNVTPIIQSNNNMNNMNNKR-EYQGSSP 355
                  333344455555556666677777777777777788888888888888888777665.6666665 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.61
                  E--B-HHHHHHHHHHHHHTT.CEEEEEESSEEEESTT.................THHHHHHHHHCHCTCEEEESHHHHHCHCSE CS
  Hydrolase_3  76 kstiskedvkeiikllkenn.veillytedkvyvlnk................eksekkkkeeektkkkkeeidseeeledeei 142
                  +++ + +++ke+ik+l   + v+ ++ +++++   n+                 ++++    e+ t ++++  + ++e e+ ei
   EFC36082.1 310 SNNSNDNQIKEFIKALALCHnVTPIIQSNNNMNNMNNkreyqgsspdeialvkFAEQSGLILENRTLTQMTLRNPNNEFENYEI 393
                  444455666777766665554777777777777666645555555555555443333333444444444444444444444444 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.17
                  --HHHHHHHHHHHHTTSEEEEE-SS-HHH CS
  Hydrolase_3  16 isektkeaikklkekgikvviATGRslra 44 
                  ++e+ ++ +++l+++gik+   TG ++++
   EFC36082.1 504 LQENVQQSLEQLRNAGIKIWMLTGDKVET 532
                  57889999***********9999976665 PP

  == domain 5  score: 16.5 bits;  conditional E-value: 1.8e-06
                  T--GGGEEEEESSGGGHHHHHHSSEEE CS
  Hydrolase_3 200 nisleeviafGDgeNDieMLeaaglgv 226
                  ++++++++a+GDg ND++M+  a++g+
   EFC36082.1 581 KLTRKQTAAIGDGGNDVSMILNANVGI 607
                  78899***************9998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (854 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1424  (0.0794244); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.51
# Mc/sec: 4992.45
//
Query:       EFC36083.1  [L=737]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.98    9.4   3.6         13    5.9   0.1    3.4  3  IQ        IQ calmodulin-binding motif


Domain annotation for each model (and alignments):
>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1     0.073   1.3e+03      13      20 ..     440     447 ..     440     448 .. 0.92
   2 ?    2.2   0.0     0.012   2.1e+02       7      12 ..     457     462 ..     455     469 .. 0.87
   3 ?    5.9   0.1   0.00075        13       6      20 ..     525     539 ..     525     540 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.073
                 HHHHHHHH CS
          IQ  13 GylaRkry 20 
                 Gyl R+r+
  EFC36083.1 440 GYLERRRF 447
                 9******9 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.012
                 HHHHHH CS
          IQ   7 IQaawR 12 
                 IQa+wR
  EFC36083.1 457 IQARWR 462
                 9***** PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.00075
                 HHHHHHHHHHHHHHH CS
          IQ   6 kIQaawRGylaRkry 20 
                 +IQ+  RG   Rk++
  EFC36083.1 525 TIQSLLRGEIYRKYL 539
                 6************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (737 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1623  (0.0905237); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 4311.18
//
Query:       EFC36084.1  [L=535]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   3.7e-110  367.3   0.1   5.2e-110  366.8   0.1    1.2  1  Thymidylat_synt  Thymidylate synthase
    2.1e-21   76.3   0.0    2.4e-17   63.1   0.0    2.4  2  DHFR_1           Dihydrofolate reductase


Domain annotation for each model (and alignments):
>> Thymidylat_synt  Thymidylate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  366.8   0.1  5.8e-114  5.2e-110       2     268 .]     250     535 .]     249     535 .] 0.94

  Alignments for each domain:
  == domain 1  score: 366.8 bits;  conditional E-value: 5.8e-114
                      HHHHHHHH.HHHH-EEEE-TTSSEEEEEEEEEEEEEGGGCB----SSST--HHHHHHHHHHHHTT--BTHHHHTTT--TTH...........HH CS
  Thymidylat_synt   2 qYldlvrk.ileeGeekedRtgtgtisvfgaqlrfdlsegefPllTtkkvflksvieEllWflsgetnvkeLqekgvkiWd...........ew 83 
                      qYld++++ il++ + +e+Rtg+gt+s fg+q++++l+++ fPllTtk+vf+k v++El+Wf+sg+tn+k L+e++++iWd            +
       EFC36084.1 250 QYLDIIKElILSDINVREERTGVGTVSKFGYQMKYSLRNNVFPLLTTKRVFWKGVAKELFWFISGSTNAKILSEQDIHIWDgngsreyldslGF 343
                      8*****9846667799999**************************************************************8877744444423 PP

                      H.HHTTB-SSSHHHHHHHBTST........TTSSB-HHHHHHHHHHHSTT-ST-EEE---GGGGGGSSS--SEEEEEEEE..SEETEEEEEEEE CS
  Thymidylat_synt  84 a.deegdlgpvYGkqwrkfkae........egkkidqlakvidqlkenpdsRriivsawnpaeldkmaLppChvlfqfyvkdkkegkLslqlyq 168
                      + +ee dlgpvYG+qwr+++++        ++k++dql+k+i++lk+np++Rrii+sawn+++l++maLppCh+++qf+v+ + +++Ls+q+yq
       EFC36084.1 344 EnREEMDLGPVYGFQWRHWGSSyenmhtdyTNKGVDQLKKCIETLKNNPTNRRIILSAWNVSDLPNMALPPCHLMCQFWVD-TDTNELSCQMYQ 436
                      336668*************999999***999*************************************************6.44589******* PP

                      EEEETTTHHHHHHHHHHHHHHHHHHHHT-EEEEEEEEEEEEEEEGGGHHHHHHHHTS---S--EEEE--SSTHSGGG--GGGEEEES----SXX CS
  Thymidylat_synt 169 RSaDvflGvpFNiasyalLthmlaqvtglkpgelihtigdaHiYsnhveqvkeqlereprelpklelnkekkvsiedfeledfelenYkphpki 262
                      RS+D++lGvpFNiasyalLt ++aqv++lkpg++iht+gd+H+Y+nh+e +k+q+er+p+++p l l+++++ +i+df++e+++l+nY+ph +i
       EFC36084.1 437 RSCDMGLGVPFNIASYALLTRLMAQVCNLKPGDFIHTLGDTHVYKNHIEPLKKQIERDPKHFPLLLLDPSIT-NIDDFKFEHLTLQNYEPHATI 529
                      *******************************************************************98887.********************* PP

                      XXXXX. CS
  Thymidylat_synt 263 kakvav 268
                      k+++av
       EFC36084.1 530 KMEMAV 535
                      *****8 PP

>> DHFR_1  Dihydrofolate reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.7   0.0   3.6e-05      0.32       5      37 ..      20      56 ..      17      59 .. 0.77
   2 !   63.1   0.0   2.7e-21   2.4e-17      38     129 ..      95     198 ..      84     242 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 3.6e-05
                EEEEE.TT-EEEBTTB-SS...--HHHHHHHHHHHTT CS
      DHFR_1  5 ivAva.engvIGkdnklpw...hlpeDlkrFkklTtg 37
                +vAv  + + IG +++lpw    l eD+k+F ++T  
  EFC36084.1 20 VVAVLlNSNGIGLNGNLPWlqdGLTEDMKHFVSVTCS 56
                5555515579*********555599*******99975 PP

  == domain 2  score: 63.1 bits;  conditional E-value: 2.7e-21
                 CEEEEEHHHHHCC-...S--.TTCEEEEE-S-TT....---TTEEEESSHHHHCCCCTTS..SEEEEEE-HHHHHHCGGG-SEEEEEEES....S---- CS
      DHFR_1  38 kpvimGrkTfeslg..krpL.pnrkniVltrned....lkvegvevvssleealalakee.keevfviGGaeiYkqalpladklylTeid....aefeg 124
                 ++vimGrkT+es++  ++pL +nr+ i+l+++ +    l +e +++v++++e+++l +++  +++f++GG +iYk +lp++  ++ T+i      +++ 
  EFC36084.1  95 NAVIMGRKTWESIPskFKPLsKNRHAIILSSKVNdddqLMMERTTFVKNVDELFELLQNQkFNRIFIAGGTSIYKLLLPYTAVIHYTNIIeqkgVNIQV 193
                 689**********98778994479999999876644333337888**********66666589*************************97555566799 PP

                 SEE-- CS
      DHFR_1 125 dtffp 129
                 dt fp
  EFC36084.1 194 DTRFP 198
                 99999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (535 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       758  (0.0422779); expected 358.6 (0.02)
Passed bias filter:                      583  (0.0325172); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 3226.44
//
Query:       EFC36085.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-05   23.4   2.0    6.3e-05   22.5   2.0    1.4  1  SWIM      SWIM zinc finger
  ------ inclusion threshold ------
      0.066   13.7   0.1       0.11   13.1   0.1    1.3  1  DUF4706   Domain of unknown function (DUF4706)


Domain annotation for each model (and alignments):
>> SWIM  SWIM zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   2.0   7.1e-09   6.3e-05      13      38 ..     125     156 ..     117     158 .. 0.94

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 7.1e-09
        SWIM  13 nkatCsCpefqk......ngipCkHalAvlla 38 
                 + ++C+C +f +       + +CkH+lAv+la
  EFC36085.1 125 SNNYCTCHSFAFavltrkESRYCKHLLAVILA 156
                 5689*************************997 PP

>> DUF4706  Domain of unknown function (DUF4706)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   1.2e-05      0.11      11      82 ..       5      89 ..       2     102 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.2e-05
     DUF4706 11 rkImedkeeikekyepewerlspkeqdelideslvkpevraky.............keesserekeelfpklklktgqkivhdee 82
                + Imed ++ +++++ +  ++++++q   ++++ ++p++   +              +++  +e ++lfp ++l +  +++ +e+
  EFC36085.1  5 TNIMEDDDHQQHEQHRNETTITNQQQYAFVNNCTIQPTSPMYMfeillrsirdsktLNDDMLKELANLFPSTTLVHALELIDKEK 89
                579*****9999999999********************99854677777777665545566677888889998888888777654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       787  (0.0438954); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 1078.65
//
Query:       EFC36086.1  [L=264]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.2e-07   30.6   0.0    0.00013   22.2   0.0    3.4  4  TPR_12    Tetratricopeptide repeat
      9e-05   22.4   1.7      0.034   14.4   0.0    4.4  6  TPR_8     Tetratricopeptide repeat
     0.0005   20.0   0.1      0.013   15.5   0.0    3.1  4  TPR_2     Tetratricopeptide repeat
     0.0078   16.2   0.5       0.35   11.0   0.0    3.3  4  TPR_7     Tetratricopeptide repeat
     0.0079   16.0   0.0      0.047   13.5   0.0    2.4  3  TPR_1     Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.01   15.7   0.0      0.041   13.8   0.0    2.0  1  TPR_10    Tetratricopeptide repeat
        0.1   13.5   0.0        2.3    9.3   0.0    3.0  4  TPR_14    Tetratricopeptide repeat
       0.11   12.9   0.4       0.59   10.6   0.1    2.4  2  TPR_17    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.053   1.2e+02      10      31 ..       6      27 ..       3      30 .. 0.91
   2 !   22.2   0.0   5.8e-08   0.00013       4      72 ..      43     111 ..      40     111 .. 0.93
   3 ?   -1.3   0.0       1.2   2.7e+03       9      36 ..     133     160 ..     125     168 .. 0.64
   4 ?   -0.4   0.0      0.66   1.5e+03      50      69 ..     179     198 ..     171     207 .. 0.54

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.053
      TPR_12 10 aavlrrlgrydeAlellekale 31
                a++l+ +g  d+ +el++ka++
  EFC36086.1  6 ASILNSMGLNDQGFELHNKAIQ 27
                8999***************975 PP

  == domain 2  score: 22.2 bits;  conditional E-value: 5.8e-08
      TPR_12   4 talnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72 
                  a ++l++ ++ +g+  +A +++ek+l i +  +G  +p+t  t   L+rly+++++ +  + l e+al
  EFC36086.1  43 LAFHELGEYYLNRGETGKAVQNFEKSLSISEGFYGWMSPQTTKTALLLSRLYLETNKVDFSVILGEKAL 111
                 57889***************************************************9999888888887 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 1.2
      TPR_12   9 laavlrrlgrydeAlellekaleiarrl 36 
                 la ++ r g y   ++   ++++i rr 
  EFC36086.1 133 LARAYERKGFYPFQQSTISRVYNILRRK 160
                 7777777777766666666666666655 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.66
      TPR_12  50 nLgrlyralgryeeAlelle 69 
                  +g + + +g+++ A + ++
  EFC36086.1 179 MMGSCRFFQGHLKLADQTFT 198
                 34444444455444444443 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       1.5   3.4e+03       7      28 ..       5      26 ..       3      27 .. 0.76
   2 !   14.4   0.0   1.5e-05     0.034       4      32 ..      45      73 ..      43      75 .. 0.92
   3 ?   -1.6   0.0         2   4.5e+03       5      16 ..      88      99 ..      85     101 .. 0.79
   4 ?   -3.0   0.0       5.5   1.2e+04       7      15 ..     133     141 ..     133     141 .. 0.70
   5 ?    3.2   0.0     0.059   1.3e+02       6      31 ..     179     204 ..     178     206 .. 0.88
   6 ?   -2.1   0.0       2.8   6.2e+03      14      21 ..     213     220 ..     211     223 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.5
                HHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8  7 lgsiylklgdyeeAkeyyekal 28
                ++si+ ++g  ++  e  +ka+
  EFC36086.1  5 KASILNSMGLNDQGFELHNKAI 26
                7899999999888777666665 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.5e-05
                HHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8  4 yynlgsiylklgdyeeAkeyyekaleldp 32
                 + lg  yl+ g+  +A++ +ek l++++
  EFC36086.1 45 FHELGEYYLNRGETGKAVQNFEKSLSISE 73
                688***********************986 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 2
                HHHHHHHHHTT- CS
       TPR_8  5 ynlgsiylklgd 16
                ++l+++yl++++
  EFC36086.1 88 LLLSRLYLETNK 99
                579999*99887 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 5.5
                 HHHHHHHTT CS
       TPR_8   7 lgsiylklg 15 
                 l+++y+ +g
  EFC36086.1 133 LARAYERKG 141
                 678887776 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.059
                 HHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   6 nlgsiylklgdyeeAkeyyekaleld 31 
                 ++gs+ + +g ++ A +++ k  +l+
  EFC36086.1 179 MMGSCRFFQGHLKLADQTFTKLDQLA 204
                 789999**************998876 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 2.8
                 TT-HHHHH CS
       TPR_8  14 lgdyeeAk 21 
                 ++d eeA+
  EFC36086.1 213 KKDSEEAQ 220
                 8999*997 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   5.9e-06     0.013       3      32 ..      44      73 ..      42      75 .. 0.91
   2 ?   -2.9   0.0       4.9   1.1e+04       7      27 ..      90     110 ..      88     111 .. 0.68
   3 ?    0.2   0.1      0.46     1e+03       6      17 ..     132     143 ..     131     144 .. 0.84
   4 ?   -2.2   0.0       2.7   6.1e+03       6      26 ..     179     199 ..     178     200 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 5.9e-06
       TPR_2  3 alynlGlayyklgdyeeAleafekAleldP 32
                a ++lG+ y+++g+  +A++ fek+l++ +
  EFC36086.1 44 AFHELGEYYLNRGETGKAVQNFEKSLSISE 73
                7899**********************9875 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 4.9
       TPR_2   7 lGlayyklgdyeeAleafekA 27 
                 l ++y++ ++ +  + + ekA
  EFC36086.1  90 LSRLYLETNKVDFSVILGEKA 110
                 677888888877666666666 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.46
       TPR_2   6 nlGlayyklgdy 17 
                 +l++ay+++g y
  EFC36086.1 132 YLARAYERKGFY 143
                 799****99966 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 2.7
       TPR_2   6 nlGlayyklgdyeeAleafek 26 
                 ++G + + +g+++ A + f k
  EFC36086.1 179 MMGSCRFFQGHLKLADQTFTK 199
                 578888999999988777766 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.0   0.00015      0.35       1      29 [.      44      72 ..      44      77 .. 0.89
   2 ?   -2.7   0.0       3.6   8.1e+03      20      26 ..     119     125 ..     118     128 .. 0.77
   3 ?    0.9   0.0      0.26   5.9e+02       4      13 ..     132     141 ..     131     143 .. 0.88
   4 ?   -1.6   0.0       1.7   3.8e+03       5      24 ..     180     199 ..     178     207 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00015
       TPR_7  1 aLlnLarlysrlGdyeeAielyeqsLalt 29
                a++ L++ y ++G++ +A++ +e+sL + 
  EFC36086.1 44 AFHELGEYYLNRGETGKAVQNFEKSLSIS 72
                6789********************99775 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3.6
       TPR_7  20 elyeqsL 26 
                 +lye++L
  EFC36086.1 119 DLYEAQL 125
                 6999988 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.26
       TPR_7   4 nLarlysrlG 13 
                 +Lar+y+r G
  EFC36086.1 132 YLARAYERKG 141
                 8******987 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 1.7
       TPR_7   5 LarlysrlGdyeeAielyeq 24 
                 ++++++ +G+ + A + +++
  EFC36086.1 180 MGSCRFFQGHLKLADQTFTK 199
                 67777778888888888877 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.6   5.7e+03      10      28 ..       8      26 ..       5      27 .. 0.59
   2 !   13.5   0.0   2.1e-05     0.047       3      32 ..      44      73 ..      42      75 .. 0.90
   3 ?   -2.6   0.0       2.7   6.1e+03       6      24 ..     179     197 ..     176     199 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.6
                HHHHTT-HHHHHHHHHHHH CS
       TPR_1 10 ayfklgkydeAleyyekAL 28
                ++ ++g  d+  e  +kA+
  EFC36086.1  8 ILNSMGLNDQGFELHNKAI 26
                5566666666666667776 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 2.1e-05
                HHHHHHHHHHHTT-HHHHHHHHHHHHHHST CS
       TPR_1  3 alynlGnayfklgkydeAleyyekALelnP 32
                a+  lG  y++ g+  +A++ +ek L++ +
  EFC36086.1 44 AFHELGEYYLNRGETGKAVQNFEKSLSISE 73
                7788**********************9975 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 2.7
                 HHHHHHHHTT-HHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyy 24 
                  +G + f +g ++ A + +
  EFC36086.1 179 MMGSCRFFQGHLKLADQTF 197
                 5799999999988886555 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.8e-05     0.041       5      33 ..      45      73 ..      43      74 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.8e-05
      TPR_10  5 lnNLanalrqrgrydeAealleealairr 33
                 + L+ ++ +rg+  +A++ +e++l+i +
  EFC36086.1 45 FHELGEYYLNRGETGKAVQNFEKSLSISE 73
                589**********************9976 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       4.9   1.1e+04       8      29 ..       6      27 ..       5      34 .. 0.78
   2 ?    9.3   0.0     0.001       2.3       4      31 ..      45      72 ..      43      79 .. 0.88
   3 ?   -1.6   0.1       3.1     7e+03       7      15 ..     133     141 ..     131     143 .. 0.80
   4 ?   -1.6   0.0       3.2   7.2e+03      33      43 ..     215     225 ..     211     226 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 4.9
      TPR_14  8 aeallalGdpdeAiallrrala 29
                a++l   G  d+  +l ++a++
  EFC36086.1  6 ASILNSMGLNDQGFELHNKAIQ 27
                6678888999999999999988 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.001
      TPR_14  4 llalaeallalGdpdeAiallrralala 31
                  +l+e++l++G++ +A++ +++ l+  
  EFC36086.1 45 FHELGEYYLNRGETGKAVQNFEKSLSIS 72
                6789*******************99876 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 3.1
      TPR_14   7 laeallalG 15 
                 la+a+++ G
  EFC36086.1 133 LARAYERKG 141
                 899999988 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 3.2
      TPR_14  33 ddaeawlllaq 43 
                 d++ea+++la 
  EFC36086.1 215 DSEEAQFELAY 225
                 78999999996 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   0.00026      0.59      13      34 .]      42      63 ..      36      63 .. 0.92
   2 ?   -2.1   0.0       3.1     7e+03      18      27 ..     132     141 ..     131     141 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00026
      TPR_17 13 adaynnLAelllknGdlmtArq 34
                + a+++L+e++l++G++++A+q
  EFC36086.1 42 SLAFHELGEYYLNRGETGKAVQ 63
                5689****************87 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 3.1
      TPR_17  18 nLAelllknG 27 
                 +LA++++++G
  EFC36086.1 132 YLARAYERKG 141
                 7999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (264 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1575.85
//
Query:       EFC36087.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.05   13.8   0.0      0.081   13.1   0.0    1.4  1  BET       Bromodomain extra-terminal - transcription regulati
      0.093   12.6   0.0       0.13   12.2   0.0    1.2  1  ADH_N_2   N-terminal domain of oxidoreductase


Domain annotation for each model (and alignments):
>> BET  Bromodomain extra-terminal - transcription regulation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0     9e-06     0.081      12      43 ..      78     108 ..      74     111 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 9e-06
         BET  12 eeInkLpgeklgrvveIIqerepelqsdedEi 43 
                 + +n+L++ +l+++  IIq ++ ++ s+ d i
  EFC36087.1  78 KPLNQLEQSMLQGITSIIQANNESF-SSGDYI 108
                 669*******************887.666655 PP

>> ADH_N_2  N-terminal domain of oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   1.5e-05      0.13      55      99 ..      75     119 ..      67     121 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.5e-05
     ADH_N_2  55 syvepve.lgdvmrggavgeVveSknpdfkvGdlVvgllgwqdyav 99 
                 s  +p++ l++ m  +++  +++ +n++f+ Gd+++ +  +++y++
  EFC36087.1  75 STSKPLNqLEQSM-LQGITSIIQANNESFSSGDYITIQKRYEQYVI 119
                 4444554144444.47899*******************99999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       844  (0.0470746); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 793.54
//
Query:       EFC36088.1  [L=2254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-70  231.5 478.4    6.7e-05   23.2  10.9   29.0 29  EGF_2     EGF-like domain
    1.2e-05   25.1   0.0      0.016   15.2   0.0    3.3  2  NHL       NHL repeat
     0.0059   16.9   4.0     0.0059   16.9   4.0   28.5 28  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   7.8   2.4e-06     0.014       4      32 .]     156     183 ..     153     183 .. 0.88
   2 !   23.2  10.9   1.1e-08   6.7e-05       5      32 .]     196     222 ..     191     222 .. 0.91
   3 !   21.2   9.2   4.6e-08   0.00028       6      32 .]     236     261 ..     230     261 .. 0.92
   4 !   17.0  11.7   9.7e-07    0.0058       7      32 .]     276     300 ..     266     300 .. 0.90
   5 !   13.7   9.8   9.9e-06     0.059       5      32 .]     313     339 ..     310     339 .. 0.87
   6 !   15.9  10.1   2.1e-06     0.013       8      32 .]     355     378 ..     349     378 .. 0.90
   7 !   12.1   8.6   3.2e-05      0.19       4      32 .]     390     417 ..     387     417 .. 0.90
   8 !   13.0  11.1   1.7e-05       0.1       3      32 .]     428     456 ..     426     456 .. 0.92
   9 !   12.3  10.0   2.7e-05      0.16       5      32 .]     469     495 ..     461     495 .. 0.90
  10 !   18.8   5.9   2.6e-07    0.0015       5      32 .]     508     534 ..     504     534 .. 0.91
  11 !   12.2  10.4     3e-05      0.18       5      32 .]     547     573 ..     539     573 .. 0.90
  12 !   16.2  12.8   1.8e-06      0.01       5      32 .]     586     612 ..     578     612 .. 0.88
  13 !   20.1  10.0     1e-07   0.00063       5      32 .]     625     651 ..     622     651 .. 0.92
  14 !   15.6  13.3   2.5e-06     0.015       6      32 .]     665     690 ..     656     690 .. 0.89
  15 !   16.7   7.6   1.2e-06    0.0073       5      32 .]     703     729 ..     699     729 .. 0.88
  16 !   17.6   9.2     6e-07    0.0036       5      32 .]     742     768 ..     736     768 .. 0.92
  17 !   15.7  12.2   2.4e-06     0.014       5      32 .]     781     807 ..     773     807 .. 0.90
  18 !   17.8   6.5   5.5e-07    0.0033       5      32 .]     820     846 ..     817     846 .. 0.92
  19 !   14.0   6.6   8.1e-06     0.048       5      32 .]     859     885 ..     856     885 .. 0.91
  20 !   18.7  12.6   2.7e-07    0.0016       5      32 .]     898     924 ..     890     924 .. 0.89
  21 !   14.1   7.9   7.8e-06     0.047       6      32 .]     938     963 ..     933     963 .. 0.89
  22 !   15.3   7.4   3.2e-06     0.019       5      32 .]     976    1002 ..     973    1002 .. 0.91
  23 !   19.7  11.0   1.4e-07   0.00083       5      32 .]    1015    1041 ..    1007    1041 .. 0.87
  24 !   18.4   7.1   3.6e-07    0.0021       6      32 .]    1055    1080 ..    1051    1080 .. 0.95
  25 !    6.2   9.0    0.0023        13       4      24 ..    1097    1116 ..    1090    1129 .. 0.82
  26 !   10.3  13.5   0.00012      0.71       4      32 .]    1146    1182 ..    1143    1182 .. 0.76
  27 ?   -2.0   3.4       0.8   4.8e+03      22      32 .]    1184    1194 ..    1177    1194 .. 0.87
  28 ?   -3.8   3.2       2.9   1.7e+04      13      28 ..    1844    1865 ..    1844    1869 .. 0.67
  29 ?   -0.5   1.0      0.29   1.7e+03      14      28 ..    2152    2171 ..    2140    2174 .. 0.65

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2.4e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+  GtC +++ +C C+sgy+G  C
  EFC36088.1 156 NSSVCSSLGTCSSPN-NCTCQSGYYGVVC 183
                 4789********999.8*********877 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 1.1e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG+C +++ +C C+sgy+G++C
  EFC36088.1 196 SSVCSGHGSCQSSN-NCTCKSGYYGANC 222
                 679*******9888.8************ PP

  == domain 3  score: 21.2 bits;  conditional E-value: 4.6e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g G+C++++ +C C sgy+G +C
  EFC36088.1 236 KVCSGKGVCNSPN-NCTCRSGYYGSNC 261
                 67********999.8************ PP

  == domain 4  score: 17.0 bits;  conditional E-value: 9.7e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+++G+C ++  +C+C+sgy+G  C
  EFC36088.1 276 VCSNRGSCLSPQ-NCSCQSGYYGEEC 300
                 7********999.7***********9 PP

  == domain 5  score: 13.7 bits;  conditional E-value: 9.9e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g+G+C ++  +C+C+ gy+G+ C
  EFC36088.1 313 SFVCSGRGICQSSQ-NCSCQLGYYGNVC 339
                 568*******9888.6*********998 PP

  == domain 6  score: 15.9 bits;  conditional E-value: 2.1e-06
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 C g G+C +++ +C+C++gy+G +C
  EFC36088.1 355 CTGSGSCLAPN-NCSCENGYYGISC 378
                 ********999.8************ PP

  == domain 7  score: 12.1 bits;  conditional E-value: 3.2e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C ghG C +++ +C C+ +++G  C
  EFC36088.1 390 SSNVCYGHGNCSAFN-NCTCSMNFYGYEC 417
                 4789********999.8*********999 PP

  == domain 8  score: 13.0 bits;  conditional E-value: 1.7e-05
       EGF_2   3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++++ C+g G+C +++ +C+C+ g++G++C
  EFC36088.1 428 NNGSVCSGVGSCLSPN-NCSCSIGHYGNNC 456
                 45899********999.8************ PP

  == domain 9  score: 12.3 bits;  conditional E-value: 2.7e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+C ++  +C C++ y+G +C
  EFC36088.1 469 STVCSGYGSCLSPD-NCNCKNAYYGRNC 495
                 678********999.8************ PP

  == domain 10  score: 18.8 bits;  conditional E-value: 2.6e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G+C +++ +C C+ +y+G +C
  EFC36088.1 508 SNVCSLNGICSSPN-NCTCNENYYGYDC 534
                 679********999.8***********9 PP

  == domain 11  score: 12.2 bits;  conditional E-value: 3e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+  G+C +++ +C+C+ gy+G +C
  EFC36088.1 547 SHVCSSKGQCLSFN-NCSCQLGYYGINC 573
                 567********999.8************ PP

  == domain 12  score: 16.2 bits;  conditional E-value: 1.8e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C g G+C++++ +C Cd+gy+G +C
  EFC36088.1 586 SSVCYGKGVCNSPN-NCTCDTGYYGSNC 612
                 789********999.8************ PP

  == domain 13  score: 20.1 bits;  conditional E-value: 1e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++iC+ +G+C++++ +C C +gy+G  C
  EFC36088.1 625 SNICSSNGYCNSPN-NCICMNGYYGQEC 651
                 79*********999.8***********9 PP

  == domain 14  score: 15.6 bits;  conditional E-value: 2.5e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ hG C ++  +C+C+sgy+G  C
  EFC36088.1 665 QVCSKHGECSTPQ-NCSCQSGYYGQEC 690
                 67********999.7***********9 PP

  == domain 15  score: 16.7 bits;  conditional E-value: 1.2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C ++  +C+C+ gy+G+ C
  EFC36088.1 703 SLVCSGRGICQSSQ-NCSCQLGYYGNVC 729
                 789*******9888.6*********998 PP

  == domain 16  score: 17.6 bits;  conditional E-value: 6e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C g G+C +++ +C+C++gy+G++C
  EFC36088.1 742 STVCTGSGSCLAPN-NCSCENGYHGDSC 768
                 578********999.8************ PP

  == domain 17  score: 15.7 bits;  conditional E-value: 2.4e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+++G+Cv+++ +C+C+ g++G++C
  EFC36088.1 781 SNVCSQNGSCVSPN-NCSCQLGHYGNNC 807
                 789********999.8************ PP

  == domain 18  score: 17.8 bits;  conditional E-value: 5.5e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ hG C++++ +C+C++gy+G  C
  EFC36088.1 820 SKVCSSHGLCISPN-ECSCQFGYFGFEC 846
                 568********999.9*********999 PP

  == domain 19  score: 14.0 bits;  conditional E-value: 8.1e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+  G C++++  C C +gy+G +C
  EFC36088.1 859 SQVCSLFGECISPN-HCNCRNGYYGLDC 885
                 568********999.9***********9 PP

  == domain 20  score: 18.7 bits;  conditional E-value: 2.7e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hG C +++ +C+C++gy+G++C
  EFC36088.1 898 SNVCSKHGNCSKPN-ECKCKDGYSGNSC 924
                 789********999.9************ PP

  == domain 21  score: 14.1 bits;  conditional E-value: 7.8e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG Cv+++ +C+C+ gy  ++C
  EFC36088.1 938 TVCSKHGECVSPN-NCSCEEGYNENNC 963
                 67********999.8*******98888 PP

  == domain 22  score: 15.3 bits;  conditional E-value: 3.2e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ hG+C n++ +C+C + y+G +C
  EFC36088.1  976 SQVCSTHGSCLNPN-NCSCVDDYFGESC 1002
                  568*******9999.8***********9 PP

  == domain 23  score: 19.7 bits;  conditional E-value: 1.4e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C  ++ +C C +gy+G+ C
  EFC36088.1 1015 SSVCSGNGKCQIPN-NCTCYDGYYGDEC 1041
                  789*******7677.8************ PP

  == domain 24  score: 18.4 bits;  conditional E-value: 3.6e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g+G+C++++  C+C+ +y+G+ C
  EFC36088.1 1055 NVCNGNGSCISPN-ICSCQYSYYGNEC 1080
                  57********999.************* PP

  == domain 25  score: 6.2 bits;  conditional E-value: 0.0023
       EGF_2    4 sdeiCgghGtCvnqcGqCdCd 24  
                  ++  C+g+G C + + +C+C+
  EFC36088.1 1097 DNQVCSGRGNCSSHN-NCSCE 1116
                  4789*******9666.8***4 PP

  == domain 26  score: 10.3 bits;  conditional E-value: 0.00012
       EGF_2    4 s...deiCgghGtCvnqcGqCdC.....dsgyqGktC 32  
                      + +C+ hG+C +  G+C C     +  + G +C
  EFC36088.1 1146 YcndNVTCSSHGKCSDDDGKCLChsnsiQGYWNGTNC 1182
                  5555899*******9999*****86666666667776 PP

  == domain 27  score: -2.0 bits;  conditional E-value: 0.8
       EGF_2   22 dCdsgyqGktC 32  
                  +C++ y+G +C
  EFC36088.1 1184 MCQDTYYGEDC 1194
                  6********** PP

  == domain 28  score: -3.8 bits;  conditional E-value: 2.9
       EGF_2   13 tCvnqcG........qCdCdsgyq 28  
                  tC   +G         C C +g+ 
  EFC36088.1 1844 TCF--NGgiynsqfkTCNCLPGFK 1865
                  575..44477776656***99986 PP

  == domain 29  score: -0.5 bits;  conditional E-value: 0.29
       EGF_2   14 CvnqcG.....qCdCdsgyq 28  
                  C+++       +C+C+s+ q
  EFC36088.1 2152 CDTELSdrniyKCKCSSKAQ 2171
                  554444555558***98765 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0018        11       2      27 ..      54      79 ..      53      80 .. 0.88
   2 !   15.2   0.0   2.7e-06     0.016       2      27 ..     110     136 ..     109     137 .. 0.93

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0018
                SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  2 nyPhGvavdsnGdiyVaDsenhrvqv 27
                  P+ ++ +++Gd++Va++  hr+++
  EFC36088.1 54 GGPSHLTFNQDGDLFVAEYVFHRIRK 79
                679999************99999986 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 2.7e-06
                 SSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvqv 27 
                 n+P+Gv  d  +G ++VaD++nh +++
  EFC36088.1 110 NSPRGVFFDdVTGSLFVADTNNHKIRK 136
                 78**********************986 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   3.5   0.00049       2.9       6      30 ..     160     180 ..     154     181 .. 0.81
   2 !    8.3   5.7   0.00046       2.8       6      32 .]     199     221 ..     193     221 .. 0.84
   3 ?    3.8   5.1     0.012        72       6      32 .]     238     260 ..     230     260 .. 0.80
   4 !   16.9   4.0   9.8e-07    0.0059       4      31 ..     275     298 ..     269     299 .. 0.88
   5 !    9.4   5.8   0.00021       1.3       5      31 ..     312     337 ..     305     338 .. 0.86
   6 ?    0.8   5.6       0.1   6.2e+02       5      31 ..     354     376 ..     350     377 .. 0.84
   7 ?   -4.5   7.4         3   1.8e+04       3      30 ..     391     414 ..     389     415 .. 0.80
   8 ?    0.5   6.7      0.13   7.8e+02       4      32 .]     428     455 ..     426     455 .. 0.86
   9 ?    1.4   4.3     0.068   4.1e+02       4      31 ..     470     493 ..     466     494 .. 0.82
  10 ?   -1.0   5.1      0.37   2.2e+03       4      30 ..     509     531 ..     506     531 .. 0.80
  11 ?    2.3   5.7     0.036   2.2e+02       4      32 .]     548     572 ..     539     572 .. 0.83
  12 ?    1.8   5.8     0.051   3.1e+02       6      32 .]     589     611 ..     584     611 .. 0.78
  13 ?    2.6   7.1      0.03   1.8e+02       4      30 ..     625     648 ..     623     650 .. 0.81
  14 !   10.4   5.7    0.0001      0.62       4      30 ..     664     687 ..     661     689 .. 0.87
  15 !   12.8   2.4   1.9e-05      0.11       6      31 ..     706     727 ..     699     728 .. 0.87
  16 ?    2.7   4.9     0.027   1.6e+02       6      31 ..     745     766 ..     739     767 .. 0.84
  17 ?    2.8   6.9     0.026   1.5e+02       3      32 .]     781     806 ..     779     806 .. 0.88
  18 ?    2.8   5.0     0.025   1.5e+02       5      30 ..     821     843 ..     812     843 .. 0.85
  19 ?    4.0   3.7     0.011        64       6      30 ..     862     882 ..     857     884 .. 0.85
  20 !    6.8   6.0    0.0014       8.7       3      31 ..     898     922 ..     896     923 .. 0.80
  21 !    9.1   5.5   0.00027       1.6       4      31 ..     937     961 ..     933     962 .. 0.87
  22 ?    3.2   3.5     0.019   1.1e+02       4      31 ..     977    1000 ..     974    1001 .. 0.86
  23 !    4.2   7.7    0.0093        56       4      31 ..    1013    1039 ..    1007    1040 .. 0.79
  24 ?    1.2   4.6     0.081   4.8e+02       5      30 ..    1055    1077 ..    1053    1079 .. 0.80
  25 ?   -2.1   3.4      0.84     5e+03       3      26 ..    1097    1117 ..    1095    1128 .. 0.75
  26 !    5.8   7.5    0.0029        18       1      27 [.    1147    1171 ..    1147    1181 .. 0.83
  27 ?    2.0   1.1     0.045   2.7e+02       5      28 ..    1844    1864 ..    1840    1866 .. 0.71
  28 ?   -1.3   0.5      0.49   2.9e+03      17      25 ..    2159    2167 ..    2149    2168 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00049
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 Cs  GtC ++     +C+C++Gy G
  EFC36088.1 160 CSSLGTCSSP----NNCTCQSGYYG 180
                 *******444....5********98 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00046
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs++G C      + +C+C++Gy G++
  EFC36088.1 199 CSGHGSCQ----SSNNCTCKSGYYGAN 221
                 *******5....555*********975 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.012
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs+ G C ++     +C+C +Gy G++
  EFC36088.1 238 CSGKGVCNSPN----NCTCRSGYYGSN 260
                 999999*5555....9*********86 PP

  == domain 4  score: 16.9 bits;  conditional E-value: 9.8e-07
                 TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytGk 31 
                 + Csn+G C++++    +C C++Gy G+
  EFC36088.1 275 HVCSNRGSCLSPQ----NCSCQSGYYGE 298
                 34***********....*********97 PP

  == domain 5  score: 9.4 bits;  conditional E-value: 0.00021
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                     Cs++G+C +++    +C C+ Gy G+
  EFC36088.1 312 DsfvCSGRGICQSSQ----NCSCQLGYYGN 337
                 3455*******9999....*********96 PP

  == domain 6  score: 0.8 bits;  conditional E-value: 0.1
                 TSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 pCsngGtCvdtgrggytCiCpeGytGk 31 
                  C + G C+ +     +C C +Gy G+
  EFC36088.1 354 GCTGSGSCLAPN----NCSCENGYYGI 376
                 499999998888....********996 PP

  == domain 7  score: -4.5 bits;  conditional E-value: 3
                 STTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytG 30 
                 +n C ++G C    +   +C+C++ + G
  EFC36088.1 391 SNVCYGHGNC----SAFNNCTCSMNFYG 414
                 4669999999....46669****99987 PP

  == domain 8  score: 0.5 bits;  conditional E-value: 0.13
                 TT...STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   4 np...CsngGtCvdtgrggytCiCpeGytGkr 32 
                 n+   Cs+ G C+++     +C C++G  G++
  EFC36088.1 428 NNgsvCSGVGSCLSPN----NCSCSIGHYGNN 455
                 55588*******9999....*******99975 PP

  == domain 9  score: 1.4 bits;  conditional E-value: 0.068
                 TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytGk 31 
                 + Cs+ G C+++     +C C++ y G+
  EFC36088.1 470 TVCSGYGSCLSPD----NCNCKNAYYGR 493
                 33*******9999....****9988886 PP

  == domain 10  score: -1.0 bits;  conditional E-value: 0.37
                 TTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytG 30 
                 n Cs +G+C ++     +C+C e y G
  EFC36088.1 509 NVCSLNGICSSP----NNCTCNENYYG 531
                 5599999**444....59******988 PP

  == domain 11  score: 2.3 bits;  conditional E-value: 0.036
                 TTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytGkr 32 
                 + Cs  G C++      +C C+ Gy G++
  EFC36088.1 548 HVCSSKGQCLSFN----NCSCQLGYYGIN 572
                 5599999997777....**********85 PP

  == domain 12  score: 1.8 bits;  conditional E-value: 0.051
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 C + G C ++     +C+C++Gy G++
  EFC36088.1 589 CYGKGVCNSPN----NCTCDTGYYGSN 611
                 77778884444....9*********86 PP

  == domain 13  score: 2.6 bits;  conditional E-value: 0.03
                 TT.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytG 30 
                  + Cs +G C ++     +CiC +Gy G
  EFC36088.1 625 SNiCSSNGYCNSPN----NCICMNGYYG 648
                 466*******5555....9*******99 PP

  == domain 14  score: 10.4 bits;  conditional E-value: 0.0001
                 TT.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytG 30 
                 +  Cs++G+C +++    +C C++Gy G
  EFC36088.1 664 TQvCSKHGECSTPQ----NCSCQSGYYG 687
                 456*******9999....********99 PP

  == domain 15  score: 12.8 bits;  conditional E-value: 1.9e-05
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G+C +++    +C C+ Gy G+
  EFC36088.1 706 CSGRGICQSSQ----NCSCQLGYYGN 727
                 *******9999....*********96 PP

  == domain 16  score: 2.7 bits;  conditional E-value: 0.027
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C + G C+ +     +C C +Gy+G+
  EFC36088.1 745 CTGSGSCLAPN----NCSCENGYHGD 766
                 88899998888....9*********7 PP

  == domain 17  score: 2.8 bits;  conditional E-value: 0.026
                 STTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGkr 32 
                 +n Cs +G Cv++     +C C+ G  G++
  EFC36088.1 781 SNVCSQNGSCVSPN----NCSCQLGHYGNN 806
                 466***********....*******99975 PP

  == domain 18  score: 2.8 bits;  conditional E-value: 0.025
                 T.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytG 30 
                 + Cs +G C+++     +C C+ Gy+G
  EFC36088.1 821 KvCSSHGLCISPN----ECSCQFGYFG 843
                 36*******9999....*******998 PP

  == domain 19  score: 4.0 bits;  conditional E-value: 0.011
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 Cs  G+C+++     +C C +Gy G
  EFC36088.1 862 CSLFGECISPN----HCNCRNGYYG 882
                 89999**9999....********99 PP

  == domain 20  score: 6.8 bits;  conditional E-value: 0.0014
                 STTSTTT-EE.EEETTTEEEEEECTTEEST CS
         EGF   3 pnpCsngGtC.vdtgrggytCiCpeGytGk 31 
                 +n Cs++G C  ++     +C+C+ Gy+G+
  EFC36088.1 898 SNVCSKHGNCsKPN-----ECKCKDGYSGN 922
                 466*******4444.....6*********7 PP

  == domain 21  score: 9.1 bits;  conditional E-value: 0.00027
                 TT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++ Cs++G+Cv++     +C C eGy  +
  EFC36088.1 937 HTvCSKHGECVSPN----NCSCEEGYNEN 961
                 457***********....********976 PP

  == domain 22  score: 3.2 bits;  conditional E-value: 0.019
                  TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 npCsngGtCvdtgrggytCiCpeGytGk 31  
                  + Cs +G C+++     +C C   y+G+
  EFC36088.1  977 QVCSTHGSCLNPN----NCSCVDDYFGE 1000
                  44*******9999....******99997 PP

  == domain 23  score: 4.2 bits;  conditional E-value: 0.0093
                  TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np...CsngGtCvdtgrggytCiCpeGytGk 31  
                  n+   Cs++G+C   +    +C+C  Gy G+
  EFC36088.1 1013 NNssvCSGNGKC---Q-IPNNCTCYDGYYGD 1039
                  56677*******...3.4467********97 PP

  == domain 24  score: 1.2 bits;  conditional E-value: 0.081
                  T.STTT-EEEEETTTEEEEEECTTEES CS
         EGF    5 p.CsngGtCvdtgrggytCiCpeGytG 30  
                  + C+++G C+++     +C C+  y G
  EFC36088.1 1055 NvCNGNGSCISPN----ICSCQYSYYG 1077
                  44********999....9999866666 PP

  == domain 25  score: -2.1 bits;  conditional E-value: 0.84
                  STT.STTT-EEEEETTTEEEEEECT CS
         EGF    3 pnp.CsngGtCvdtgrggytCiCpe 26  
                  +n  Cs++G C    + + +C C +
  EFC36088.1 1097 DNQvCSGRGNC----SSHNNCSCEI 1117
                  46689999999....5777888875 PP

  == domain 26  score: 5.8 bits;  conditional E-value: 0.0029
                  GCSTT.STTT-EEEEETTTEEEEEECTT CS
         EGF    1 Cspnp.CsngGtCvdtgrggytCiCpeG 27  
                  C++n  Cs +G+C  +  ++ +C C + 
  EFC36088.1 1147 CNDNVtCSSHGKC--SD-DDGKCLCHSN 1171
                  **9889*******..44.889****876 PP

  == domain 27  score: 2.0 bits;  conditional E-value: 0.045
                  TSTTT-EEEEETTTEEEEEECTTE CS
         EGF    5 pCsngGtCvdtgrggytCiCpeGy 28  
                  +C ngG  ++++ +  tC C +G+
  EFC36088.1 1844 TCFNGG--IYNS-QFKTCNCLPGF 1864
                  355555..5555.8889******9 PP

  == domain 28  score: -1.3 bits;  conditional E-value: 0.49
                  TTEEEEEEC CS
         EGF   17 rggytCiCp 25  
                  r+ y+C+C+
  EFC36088.1 2159 RNIYKCKCS 2167
                  5669****7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       808  (0.0450667); expected 358.6 (0.02)
Passed bias filter:                      255  (0.0142228); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.33u 0.37s 00:00:01.70 Elapsed: 00:00:00.60
# Mc/sec: 11400.52
//
Query:       EFC36089.1  [L=635]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-26   91.7   3.1    5.3e-26   91.7   3.1    2.3  2  mRNA_triPase   mRNA capping enzyme, beta chain
     0.0062   16.2  18.0     0.0062   16.2  18.0    1.6  2  DUF572         Family of unknown function (DUF572)
  ------ inclusion threshold ------
      0.027   12.5   1.4      0.045   11.8   1.4    1.2  1  Med24_N        Mediator complex subunit 24 N-terminal
       0.85    9.4  20.9        3.7    7.3   0.5    2.4  2  Pox_Ag35       Pox virus Ag35 surface protein
       0.86    9.2  23.1       0.11   12.2   2.0    2.3  2  BSP_II         Bone sialoprotein II (BSP-II)
          1   10.0   8.4       0.22   12.1   1.7    2.4  2  Ribosomal_60s  60s Acidic ribosomal protein
        2.3    6.7  18.9       0.58    8.6  13.3    2.0  2  Macoilin       Macoilin family


Domain annotation for each model (and alignments):
>> mRNA_triPase  mRNA capping enzyme, beta chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   5.9         1   2.6e+03      70     130 ..     213     272 ..     199     296 .. 0.68
   2 !   91.7   3.1   2.1e-29   5.3e-26       8     218 ..     315     547 ..     308     548 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1
                   HHHHHHHHHHHHHHH..HTTCCCTTTEEEEEEEEEEEEEE-S-SSS--EEEEEEETTT--E CS
  mRNA_triPase  70 dqfkelnnfLnelsrrneeenskrekvslkeskevDkfYelkkkeekskirvskdsenqev 130
                   ++ ++ +   +++++++ ++++k +k +  +s++ D+  +++ ++++++++ ++++++ + 
    EFC36089.1 213 TNTSTSSSKEQQTKEKKPKKQPKPKKSKKDQSNNSDQASNVQ-SNNNNNTSNTNNNNSSSS 272
                   555555555566667778888888888888888899998888.777777777776663222 PP

  == domain 2  score: 91.7 bits;  conditional E-value: 2.1e-29
                   HHHHHHHHHHHCTCCGGCCEEEEEEEEEEEETTTSSB---S......BSS-EEE-TTCTEEEEE-B-HHHHHHHHHHHHHHHH......HTTCCCTT CS
  mRNA_triPase   8 vsdwiiaaldniksekrsqiEiEaklGlivdkstkeRlklp......vsteaivennadskfesgvdedqfkelnnfLnelsrr....neeenskre 94 
                   + ++i+      + ++  +iE+E k+G ++ k++k+R+ ++        +e+iv++++d++f+s++  + fk++nn+Lne   +    +++++ +  
    EFC36089.1 315 LGQFIF------SLSETDNIELEGKVGYLIVKDRKQRMIPQltngshLLSEVIVHRSKDCEFQSRIPPEIFKYVNNLLNERYSSlqdlKKKKQYNGP 405
                   555555......3355689*******************6552222224579*****************************66558888889999999 PP

                   TEEEEEEEEEEEEEE-S............-SSS--EEEEEEETTT--EEEEEEEEEEE..EEEEE-TTSSSEEEEEEEEEEE-SSSHHHCTTS--SE CS
  mRNA_triPase  95 kvslkeskevDkfYelk............kkeekskirvskdsenqevlkkieKeria..dlniylPnsklDyriSinlElpvseskaklskktpvs 177
                   ++++ + +e+DkfYe               + +++ irv+ d e+ + + ++ K r++  d++ ++P++  D+riS+  E +++     l   +p++
    EFC36089.1 406 IITYGRCNETDKFYEYYlppseddvrneeGELDHRDIRVTFDTETDKPIRAMIKSRLEngDIDFSCPHRVHDFRISFRREKKIDRF-PDLNVDKPKK 501
                   9***************99*******98877778999*********************84468889*****************8877.777888999* PP

                   EEEEEEEEEEECCGTEEEEEEEE......SSS.---S--EEEEEEEEE CS
  mRNA_triPase 178 eRlkeRlSyihkksgiqfDLtkv......ekt.ektkkteekyElEiE 218
                    R+k+R+Sy+     +++DLt v      +++   ++ + +++E+E+E
    EFC36089.1 502 IRRKSRISYTFGI--CRIDLTSVesfnchKNGeIIESTKLSTFEIEVE 547
                   ***********99..********9998864444667888899*****9 PP

>> DUF572  Family of unknown function (DUF572)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2  18.0   2.4e-06    0.0062     168     316 ..     118     274 ..     110     294 .. 0.41
   2 ?   -2.6   0.0       1.2   3.2e+03     242     251 ..     611     620 ..     562     633 .. 0.47

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 2.4e-06
      DUF572 168 lelrkefreekkereeeeedeealkeki.sle....kikllpede.edekkaklle.gkte...........slfasseesaksakkkptkk....... 241
                   + k++ree+ e eeeee+ee+  e+i s      + k++p+++  + +  +l + + t+           +         k++ +            
  EFC36089.1 118 TTQFKRTREEQDEDEEEEEEEEEESEEIhS-FppppTSKQIPQNNlRSATAPALPQfMPTQqqyskqpppplP---------KMNVP----Pppqpsia 202
                 566777888888888887777777777732.235677788888885555555555544443333333333221.........11111....02223334 PP

      DUF572 242 ........esskekkkeslekklskltkkkadsslvvrKkkkeeekskeskekteeeskeseeeskkeeetsaeeekeekakk 316
                         +++++++++s+e+++++++ kk+ ++   +K ++++++++++ +++++++++++++++++++           ++
  EFC36089.1 203 nslassniTNTNTSTSSSKEQQTKEKKPKKQPKPKKSKKDQSNNSDQASNVQSNNNNNTSNTNNNNSSSS-----------TT 274
                 3333222223333333333333333333322222222222222111111111111111111111111111...........11 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.2
      DUF572 242 esskekkkes 251
                 +ss++++++s
  EFC36089.1 611 NSSRTASSSS 620
                 1111111111 PP

>> Med24_N  Mediator complex subunit 24 N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.4   1.7e-05     0.045     819     981 ..     205     369 ..     192     373 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.7e-05
     Med24_N 819 Lcvycilsaleektsqkksaltrsk.krkreakevdkedldalvqssKlrrl.....essdeaeealllssssqseasslsqlseitlkdPLqkvlkel 911
                 L++  i+ +  +++s k+++++++k k++++ k+++k++ ++  q+s +         ++++++++ ++++++++ +++    + +++  P +++ + l
  EFC36089.1 205 LASSNITNTNTSTSSSKEQQTKEKKpKKQPKPKKSKKDQSNNSDQASNVQSNnnnntSNTNNNNSSSSTTTTNTTINTT--LPPVLNIYGPFTSAANAL 301
                 4444444444433333333333222122223333344434434444444443111003333333333333333333333..347899**********99 PP

     Med24_N 912 frllssviesdelspkteFvfqflel.lvecgkdrsrtvlqllpltlvseLlkvlkdllstelvlalydlq 981
                 f      +  + + +  +F+f++ e   +e   +    + +   + ++++L    ++lls+ +v +  d +
  EFC36089.1 302 FGNDL--MYDESIRKLGQFIFSLSETdNIELEGKVGYLIVKDRKQRMIPQLTNG-SHLLSEVIVHRSKDCE 369
                 98644..56667777889****9985268888888889*************998.9999999999988866 PP

>> Pox_Ag35  Pox virus Ag35 surface protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.5    0.0014       3.7      67      95 ..     117     143 ..      81     166 .. 0.59
   2 ?    5.8  14.1     0.004        10      47     111 ..     218     278 ..     199     286 .. 0.49

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0014
    Pox_Ag35  67 kekkkkeeekeeaaeeeeledseedeene 95 
                  + + k+ ++e+ ++ee  e++ee+ee+e
  EFC36089.1 117 TTTQFKRTREEQDEDEE--EEEEEEEESE 143
                 22222222222222222..1111111111 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.004
    Pox_Ag35  47 Pspkqekkkrattprkkpakkekkkkeeekeeaaeeeeledseedeenendedeseesvqaeeek 111
                  s k++++k  + p+k+p  k++kk +++++ +a +   + ++++ + +n +++++ s ++ +++
  EFC36089.1 218 SSSKEQQTK-EKKPKKQPKPKKSKKDQSNNSDQASNV--QSNNNN-NTSNTNNNNSSSSTTTTNT 278
                 344544444.566777766666555555544444433..333322.2333333333333333333 PP

>> BSP_II  Bone sialoprotein II (BSP-II)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   2.0   4.2e-05      0.11     130     154 ..     122     144 ..      83     147 .. 0.54
   2 ?    2.1  13.5      0.05   1.3e+02     105     234 ..     216     283 ..     200     296 .. 0.37

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 4.2e-05
      BSP_II 130 atkeeesdeeeeeeeeeeneeeeae 154
                    +ee+de+eeeeee e+ee+e e
  EFC36089.1 122 KRTREEQDEDEEEEEE-EEEESE-E 144
                 2344555555555553.333333.3 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.05
      BSP_II 105 ktqgkgsiGlaaiklpkkagdieekatkeeesdeeeeeeeeeeneeeeaevdeneqgvngtstnsteaengngssggdngeeeeeesvteaeaegteve 203
                 +t+++ ++  ++ k pkk+   ++k++k++ +++++  + +++n+++  + ++n+ +                                          
  EFC36089.1 216 STSSSKEQQTKE-KKPKKQ-PKPKKSKKDQSNNSDQASNVQSNNNNNTSNTNNNNSS------------------------------------------ 270
                 111111111111.122221.1122222222222222222222333333344444444.......................................... PP

      BSP_II 204 eeeeagsaetttspnglfeattplqeaydtt 234
                                    +tt ++ + +tt
  EFC36089.1 271 ------------------SSTTTTNTTINTT 283
                 ..................4444444444444 PP

>> Ribosomal_60s  60s Acidic ribosomal protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.7   8.7e-05      0.22      61      81 ..     124     144 ..      97     148 .. 0.63
   2 ?    1.3   0.7      0.21   5.5e+02      55      75 ..     221     241 ..     200     250 .. 0.48

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 8.7e-05
                    XXXXXXXXXXXXXXX.XX--S CS
  Ribosomal_60s  61 aaaaaaeekkkeeeeeEeedd 81 
                      ++++e++++eeeeeEe+++
     EFC36089.1 124 TREEQDEDEEEEEEEEEESEE 144
                    444445555555555577876 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.21
                    XXXXXXXXXXXXXXXXXXXXX CS
  Ribosomal_60s  55 aaaaaaaaaaaaeekkkeeee 75 
                      ++ ++++++++ k+k+ ++
     EFC36089.1 221 KEQQTKEKKPKKQPKPKKSKK 241
                    223333334444444444433 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  13.3   0.00023      0.58     222     364 ..     141     276 ..     111     403 .. 0.66
   2 ?    1.5   0.2     0.034        87     235     373 ..     590     631 ..     526     635 .] 0.65

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00023
    Macoilin 222 aakelvevdpvalsknnhslnkkdsslklpeleyrekkksakssrsdskkkhehn.....esvdsklqekeymenkskskrlsksessgsesellvees 315
                  ++e+ + +p              +s+++p+ + r+ +  a  +   ++++++++      +++     +  ++n + s +++++++s+s+s+ +++++
  EFC36089.1 141 ESEEIHSFPPP------------PTSKQIPQNNLRSATAPALPQFMPTQQQYSKQpppplPKMNVPPPPQPSIANSLASSNITNTNTSTSSSKEQQTKE 227
                 33333333333............4444555555555555555555555555554455544445555566667888888888888888888888888888 PP

    Macoilin 316 vkskssssssssnknskkasagsagssnssskkhsessksvtssssskn 364
                  k k++++ ++s+k+++++s ++++ +++  ++ s+++++ +sss+++ 
  EFC36089.1 228 KKPKKQPKPKKSKKDQSNNSDQASNVQSNNNNNTSNTNNNNSSSSTTTT 276
                 8888888888888877777777777666666666666655555553332 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.034
    Macoilin 235 sknnhslnkkdsslklpeleyrekkksakssrsdskkkhehnesvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskk 333
                 ++n++s + ++    +p                                                                                  
  EFC36089.1 590 NNNSSSSSTRQPPPPVP---------------------------------------------------------------------------------- 606
                 23333333323333333.................................................................................. PP

    Macoilin 334 asagsagssnssskkhsessksvtsssssknskkqklpaG 373
                                + ++++s+t ssss++++ q+   G
  EFC36089.1 607 ---------------MVANNSSRTASSSSHHQQHQQQQYG 631
                 ...............3333444444443333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (635 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2774  (0.154721); expected 358.6 (0.02)
Passed bias filter:                      823  (0.0459033); expected 358.6 (0.02)
Passed Vit filter:                       208  (0.0116013); expected 17.9 (0.001)
Passed Fwd filter:                        68  (0.00379274); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.25u 0.42s 00:00:01.67 Elapsed: 00:00:00.57
# Mc/sec: 3347.83
//
Query:       EFC36090.1  [L=516]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.14   10.5   0.1       0.24    9.7   0.1    1.2  1  PTPS_related  6-pyruvoyl-tetrahydropterin synthase related do


Domain annotation for each model (and alignments):
>> PTPS_related  6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1   1.3e-05      0.24     531     605 ..     432     507 ..     427     512 .. 0.93

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 1.3e-05
  PTPS_related 531 qrrvarageflGvigeaesias.klqtlsfevskivpalflveaaawklvalenldvvkdllllgdkalaalvkae 605
                   +++ +++ + l++ + + s+++ +++++s+++s+i++++f +  +  ++++  n +v  + + + ++al + ++a 
    EFC36090.1 432 KNNYNNNNSTLNISAIPHSLNQsNISNISMNLSQINTSFFNSTPTTQATNITINSNVNSNSSNVTNRALSIKERAK 507
                   6788999999***********99*******************************99**************999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (516 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3048  (0.170004); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.81u 0.34s 00:00:01.15 Elapsed: 00:00:00.53
# Mc/sec: 2926.05
//
Query:       EFC36091.1  [L=384]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.047   13.3   1.9        0.5    9.9   0.2    2.2  2  Toxin_15  ShET2 enterotoxin, N-terminal region


Domain annotation for each model (and alignments):
>> Toxin_15  ShET2 enterotoxin, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1    0.0047        84       8      38 ..      13      44 ..       6      52 .. 0.79
   2 ?    9.9   0.2   2.8e-05       0.5      60     126 ..     266     333 ..     206     343 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.0047
    Toxin_15  8 ssnsekeqlksKevPYlsekksf.kvnlngqv 38
                  +s ++++ + + PY+  +k+  k n+ng+ 
  EFC36091.1 13 HISSSTSTASFSNSPYVNSEKHPiKSNVNGKS 44
                457888899999****97776666*****986 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 2.8e-05
    Toxin_15  60 ldeakGkVdykkfssedkianhvslekkeetyellskspee.iyfvenndfGlvlkkiFekmekngen 126
                 l + + k  y++fs  d+i ++  ++ +    +  ++ p+  +y+  n+ f   l + F +m+++g +
  EFC36091.1 266 LMDCEKKMFYSPFSACDTIVSEEEKKWSCSIRDGQEETPDSvVYVHSNGGFCYSLCNCFTSMKQKGMF 333
                 444566888999*****99888777776666666777776516777899****************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (384 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.23s 00:00:00.66 Elapsed: 00:00:00.38
# Mc/sec: 3029.08
//
Query:       EFC36092.1  [L=175]
Description: vacuolar H+ ATPase subunit C subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.6e-33  112.9  33.5    3.4e-20   72.1  12.6    2.2  2  ATP-synt_C  ATP synthase subunit C


Domain annotation for each model (and alignments):
>> ATP-synt_C  ATP synthase subunit C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.9  12.9   1.5e-16   2.6e-12       1      60 []      25      84 ..      25      84 .. 0.98
   2 !   72.1  12.6   1.9e-24   3.4e-20       1      59 [.     103     161 ..     103     162 .. 0.98

  Alignments for each domain:
  == domain 1  score: 46.9 bits;  conditional E-value: 1.5e-16
                HHHHHHH.GGGHHHHHHHHHHHHHHHHHHHHSGHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ATP-synt_C  1 lgaglavGlsalgsGigiGkagsagiravarnpklftksliilafaeaialygLivalil 60
                +g+++a+++s lgs++g Gkag + +    +npkl +k li+++++++++++gLiv++i+
  EFC36092.1 25 MGVACALIFSNLGSAYGAGKAGVGVAHLGILNPKLVVKGLIPVIMSGILGIFGLIVSIII 84
                699*******************************************************98 PP

  == domain 2  score: 72.1 bits;  conditional E-value: 1.9e-24
                 HHHHHHH.GGGHHHHHHHHHHHHHHHHHHHHSGHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ATP-synt_C   1 lgaglavGlsalgsGigiGkagsagiravarnpklftksliilafaeaialygLivali 59 
                 l+ gla Gls+l++G++ G+ag+ag+ra +++pk+f+++++il+f ea++lygLival+
  EFC36092.1 103 LASGLAAGLSCLAAGLALGVAGDAGVRAYGKQPKIFVGLVLILIFGEALGLYGLIVALV 161
                 799******************************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      239  (0.0133304); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1198.77
//
Query:       EFC36093.1  [L=399]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1442  (0.0804284); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.36s 00:00:01.08 Elapsed: 00:00:00.51
# Mc/sec: 2368.88
//
Query:       EFC36094.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       445  (0.0248201); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 791.39
//
Query:       EFC36095.1  [L=1396]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.5e-05   22.6   0.3       0.01   16.0   0.0    3.4  2  PKD_2     PKD-like family
    0.00018   21.8  21.8    0.00091   19.6   5.6    7.0  7  EGF_2     EGF-like domain
     0.0019   18.5   2.9     0.0019   18.5   2.9    6.4  6  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> PKD_2  PKD-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   1.7e-06      0.01      36     105 ..     289     356 ..     274     372 .. 0.86
   2 ?    2.2   0.2     0.032   1.9e+02      50     101 ..     870     955 ..     840     962 .. 0.57

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 1.7e-06
       PKD_2  36 kpklttasekdeeeleyeWkiiksskslkidtiseeedldvvvdleakkyslrlsvtdkktgityfaets 105
                 +p ++ ++++  e+++yeW ++ s+  +++ ++  e+ +++++  + +ky + +sv+d+ tg  + ++++
  EFC36095.1 289 TPLISINDGE-YERYRYEWQFQGSTRLTNTSSLYWENPFKFPIISDRDKYMF-FSVYDNYTGFLVLKRLF 356
                 4666667777.99********999*************************999.*********98887765 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.032
       PKD_2  50 leyeWkiiksskslkidtiseeedldvvvdleakkysl...................................rlsvtdkktgityf 101
                 +ey Wk   s + + +d+ s++ +l ++ +  a +  l                                   +++v+d++tg++++
  EFC36095.1 870 IEYSWKE-DSGTLTLTDSFSTQPTLVIKSNNPALTEGLklnftltvtitepgmklyyirktfetrvnnlpiiqQFKVMDNSTGLETT 955
                 4555555.3334444555555555444444444432222233333333333333344566666666666666678888888888765 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   4.9   0.00048       2.8       5      32 .]     575     606 ..     571     606 .. 0.84
   2 ?   -2.3   4.3       1.1   6.3e+03      13      32 .]     608     633 ..     607     633 .. 0.73
   3 !   19.6   5.6   1.5e-07   0.00091       6      32 .]     651     676 ..     648     676 .. 0.90
   4 !    6.8   4.1    0.0015       8.9       7      32 .]     691     715 ..     686     715 .. 0.89
   5 ?    1.0   9.5     0.095   5.7e+02       6      32 .]     728     755 ..     720     755 .. 0.87
   6 !   17.8   8.3   5.5e-07    0.0033       7      32 .]     783     809 ..     779     809 .. 0.90
   7 ?   -5.0   1.2         3   1.8e+04      23      32 .]     828     837 ..     828     837 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00048
       EGF_2   5 deiCgghGtCvnqc.G...qCdCdsgyqGktC 32 
                 +  C  +GtCv++      qC C + y+G +C
  EFC36095.1 575 CGVCEHDGTCVRKLkSkvqQCNCAPLYTGINC 606
                 678999****8777457767***********9 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.1
       EGF_2  13 tCvnqcG......qCdC.dsgyq.GktC 32 
                 tC   +G       C C   +yq G +C
  EFC36095.1 608 TCF--GGsvmindTCTCpYGKYQsGSSC 633
                 777..778877667***76666678888 PP

  == domain 3  score: 19.6 bits;  conditional E-value: 1.5e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ +G+C++ +  C+Cd gy+G  C
  EFC36095.1 651 SVCSKRGKCIEMN-TCKCDIGYTGSEC 676
                 57********666.9************ PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0015
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  Cgg G C  ++  C+C  ++ G  C
  EFC36095.1 691 VCGGIGRCAYPN-ICFCGLNFAGSEC 715
                 6*******9777.9*********999 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.095
       EGF_2   6 eiCgghGtCvnqcGqCd.CdsgyqGktC 32 
                  +C+++G+C++++  C+ C + y+G +C
  EFC36095.1 728 QACKNGGSCNTKTHLCEnCLAPYTGQDC 755
                 57********99977*779*******99 PP

  == domain 6  score: 17.8 bits;  conditional E-value: 5.5e-07
       EGF_2   7 iCgghGtCvnqcG.qCdCdsgyqGktC 32 
                  C+ghG C   +G +C+C+++y+G +C
  EFC36095.1 783 VCSGHGNCSFNNGpVCSCKTNYTGINC 809
                 5*******7667878************ PP

  == domain 7  score: -5.0 bits;  conditional E-value: 3
       EGF_2  23 CdsgyqGktC 32 
                 C+ ++ G +C
  EFC36095.1 828 CKENFGGSNC 837
                 7777777777 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   2.3   1.3e-05     0.076       6      32 .]     578     605 ..     571     605 .. 0.90
   2 ?   -2.1   1.0      0.85   5.1e+03      21      27 ..     619     625 ..     608     628 .. 0.78
   3 !   18.5   2.9   3.2e-07    0.0019       4      31 ..     649     674 ..     647     675 .. 0.89
   4 ?   -1.4   3.1      0.52   3.1e+03       5      31 ..     689     713 ..     685     714 .. 0.73
   5 ?    0.0   6.5      0.19   1.1e+03       6      30 ..     730     752 ..     720     754 .. 0.77
   6 !    9.8   5.4   0.00017         1       4      32 .]     781     808 ..     778     808 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.3e-05
                 STTT-EEEEET.TTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtg.rggytCiCpeGytGkr 32 
                 C ++GtCv+   +   +C C++ ytG++
  EFC36095.1 578 CEHDGTCVRKLkSKVQQCNCAPLYTGIN 605
                 *******999999999**********86 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.85
                 EEEECTT CS
         EGF  21 tCiCpeG 27 
                 tC+Cp G
  EFC36095.1 619 TCTCPYG 625
                 8***966 PP

  == domain 3  score: 18.5 bits;  conditional E-value: 3.2e-07
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 np  Cs++G+C++      tC+C++GytG+
  EFC36095.1 649 NPsvCSKRGKCIEMN----TCKCDIGYTGS 674
                 8999*******7777....**********6 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 0.52
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                 p  C + G+C ++     +C+C   ++G+
  EFC36095.1 689 PtvCGGIGRCAYP----NICFCGLNFAGS 713
                 4457777888433....48*****99996 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.19
                 STTT-EEEEETTTEEEEE.ECTTEES CS
         EGF   6 CsngGtCvdtgrggytCi.CpeGytG 30 
                 C+ngG C +t+  ++ C+ C  +ytG
  EFC36095.1 730 CKNGGSC-NTK--THLCEnCLAPYTG 752
                 *******.988..8888657777776 PP

  == domain 6  score: 9.8 bits;  conditional E-value: 0.00017
                 TT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 ++ Cs++G C  + ++g+ C C++ ytG++
  EFC36095.1 781 YRvCSGHGNC--SFNNGPVCSCKTNYTGIN 808
                 456*******..55799***********86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1396 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       760  (0.0423894); expected 358.6 (0.02)
Passed bias filter:                      247  (0.0137766); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.86u 0.31s 00:00:01.17 Elapsed: 00:00:00.50
# Mc/sec: 8417.16
//
Query:       EFC36096.1  [L=1115]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
          2    8.6   9.6         15    5.7   0.2    4.1  5  T2SSN     Type II secretion system (T2SS), protein N


Domain annotation for each model (and alignments):
>> T2SSN  Type II secretion system (T2SS), protein N
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0      0.64   1.2e+04      73     146 ..     541     564 ..     535     580 .. 0.49
   2 ?    0.5   0.2     0.032   5.7e+02      77     119 ..     761     804 ..     731     878 .. 0.50
   3 ?    4.6   0.4    0.0018        33      50     160 ..     875     975 ..     861     981 .. 0.77
   4 ?    5.7   0.2   0.00082        15     125     166 ..     994    1036 ..     975    1044 .. 0.61
   5 ?   -1.0   0.0     0.098   1.8e+03      70     125 ..    1053    1109 ..    1029    1113 .. 0.44

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 0.64
       T2SSN  73 sgglqlenvrlrlpaallanplsasGdvsldldelrfgrggcqalqGtlnwrnaevsslsgslplgdlraelsc 146
                 +g l++++ + ++++++l++                                                  +ls 
  EFC36096.1 541 KGSLTISGTETSFSVDQLFG--------------------------------------------------HLSI 564
                 44455555555555555543..................................................2222 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.032
       T2SSN  77 qlenvrlrlpaallanplsasGdvsldldelrfgrg.gcqalqG 119
                 +++  ++++ +++  +++++ Gd++++l +   ++  ++q+++G
  EFC36096.1 761 KISSNQGKMDVNSKNSTVKVTGDMDGHLLTSGNNTFlDLQEVKG 804
                 44444444444443334445555444444422222223333333 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.0018
       T2SSN  50 lgddartsalngk.grlaatlagssgglqlenvrlrlpaallanplsasGdvsldldelrfgrggcqalqGtlnwrnaevsslsgslplgdlraelsce 147
                 +++ + + + + k  ++ a+l gssg +  ++++  l+ ++     s++G+v l+ +++++++g    ++G+   ++   s++    +l d++++++  
  EFC36096.1 875 ANNIGGSIDSSSKqTTIDASLLGSSGSISTRGGNTVLSFNK-----SIDGKVTLHGNSANVTTG---MVKGEIDSSAL--STQIH--VLEDMTGDITTS 961
                 44444444444445788889999999999999999999999.....99************9976...34677777776..55665..788********* PP

       T2SSN 148 ggqltltlsdqs.g 160
                 g++l+l+++ +  g
  EFC36096.1 962 GDKLVLQVDRSMiG 975
                 *******9966555 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.00082
       T2SSN  125 naevsslsgslplgdlraelsceggqltltlsdqs.gpLsleg 166 
                  n  v++ + sl+l +l+++l++++g+  + ++++  g++s++g
  EFC36096.1  994 NISVEGKQSSLKLENLSGNLTSKSGATGVVVRNDMgGKMSIQG 1036
                  3445555556666666666666666666666655556666555 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 0.098
       T2SSN   70 agssgglqlenvrlrlpaallan.....plsasGdvsldlde..lrfgrggcqalqGtlnwrn 125 
                  ++s+ +  +en+++++  ++  n       ++ Gd++ +++e  ++++    ++l+G+ln+++
  EFC36096.1 1053 DSSNNDMSIENLSGTITESS--NisqatIEQLTGDFKSKAKEstVVVE----RELSGNLNVQQ 1109
                  23333333333333333333..12233322455555555555222222....34555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1115 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       893  (0.0498076); expected 358.6 (0.02)
Passed bias filter:                      243  (0.0135535); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.81u 0.28s 00:00:01.09 Elapsed: 00:00:00.49
# Mc/sec: 6851.19
//
Query:       EFC36097.1  [L=2576]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.03   14.1   0.1       0.87    9.4   0.0    3.3  2  CDC48_2   Cell division protein 48 (CDC48), domain 2
      0.051   13.5   0.6        1.2    9.1   0.0    3.3  3  ADH_N     Alcohol dehydrogenase GroES-like domain
        0.1   11.3   1.2       0.17   10.6   1.2    1.2  1  DUF935    Protein of unknown function (DUF935)


Domain annotation for each model (and alignments):
>> CDC48_2  Cell division protein 48 (CDC48), domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   0.00015      0.87       9      45 ..     435     518 ..     429     536 .. 0.71
   2 ?   -0.1   0.0      0.14   8.4e+02      30      56 ..    1686    1721 ..    1638    1725 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00015
                 HHHCCCTTEEE-TTEEE...............................................EECCTCCCEEEEEEEECCCC CS
     CDC48_2   9 ylkrqFlgrpvtkGdlv...............................................vfefkgqeiklvVvstePkg 45 
                  +k+ ++gr++tkGd+                                                  +f+g++ +l+Vv++e + 
  EFC36097.1 435 IVKKDLEGRIFTKGDTNvtsvggdlkgkfvskstntslsvsndlsglvgivegkqaflnvggntGGDFMGTASDLTVVNVEGSM 518
                 699************987888888888888888888887777777777766666666655554433666999999999998775 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.14
                  T...CCCEEEEEEEECCCC......SCEEECTSCCE CS
     CDC48_2   30 k...gqeiklvVvstePkg......pvgitetTeie 56  
                  +   g++i+ +++++e+k+      ++ it +++ie
  EFC36097.1 1686 LiveGNNIDMRAADIETKEggkihaTANITADSQIE 1721
                  1555999************88888888888888887 PP

>> ADH_N  Alcohol dehydrogenase GroES-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1      0.63   3.8e+03      27      48 ..     200     221 ..     190     224 .. 0.81
   2 ?    9.1   0.0    0.0002       1.2      25      78 ..     254     307 ..     240     338 .. 0.81
   3 ?   -0.2   0.0      0.15   9.1e+02      25      66 ..     942     983 ..     928     996 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.63
                 TTSSSSEE---EEEEEEEEEST CS
       ADH_N  27 levklplilGHEivGeveevgp 48 
                 ++ +  +i+  E++Ge++ +g+
  EFC36097.1 200 SKKSSAIIVEKEMAGEIVTTGE 221
                 56667788999*******9997 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0002
                 TTTTSSSSEE---EEEEEEEEESTT-CS--TT-EEEE-SEEE-SSSHHHHTT-G CS
       ADH_N  25 kelevklplilGHEivGeveevgpevkklkvGdrVvvepliscgeCaaCkegee 78 
                 k  +++++l +G +++Gev+++ ++ ++++vG+  + + +++ +e++ C e++ 
  EFC36097.1 254 KAKNNNFNLDIGKNMSGEVSSLSENGTRISVGNTMTGSLNSTAKESSICVENDL 307
                 6788999999***********************************999998765 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.15
                 TTTTSSSSEE---EEEEEEEEESTT-CS--TT-EEEE-SEEE CS
       ADH_N  25 kelevklplilGHEivGeveevgpevkklkvGdrVvveplis 66 
                 ++l+++l++ +G +++G  +++ +  +++kvG+    +++ +
  EFC36097.1 942 ASLNTNLNFDVGGNMSGSLQSTTETGTRIKVGQTMSGSITNK 983
                 45678888999999******99999999***99877666555 PP

>> DUF935  Protein of unknown function (DUF935)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   1.2   2.8e-05      0.17     346     478 ..    2230    2362 ..    2226    2396 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 2.8e-05
      DUF935  346 lvrplvdlNfgpqerlPrfeidveepeDlkalaealekLvelGlrvpqs..evrdklglpepeedeevlkaaesaepeaaaapaalaakaaaalaaa 440 
                  ++   v+ Nf+  +++P   +++e+++D k++ + l+k+ + G   ++s   v++k+++ + e+ e+  +++++ e+e++    +l ++a ++l+++
  EFC36097.1 2230 IITNAVNYNFD--RDAPNKIFKFENKQDEKKAETDLRKMLKEGTSYEESllRVQQKYQVYTYEQAEKRNREEGNMEKETKVLI-KLINNAIEELENT 2323
                  67777777777..9*********************************99334689***************7777777777766.5555555556666 PP

      DUF935  441 aaaeaaeqdaldaladealeea.eaalepllapvlelle 478 
                   +++++e++  +++    l+e+ +  l ++l+++++ + 
  EFC36097.1 2324 PEKDEKEKEGPKEISGDDLDEKeKPNLPEILTKLFKDIG 2362
                  666666666666666555555535566667777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1204  (0.0671538); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.97u 0.29s 00:00:01.26 Elapsed: 00:00:00.50
# Mc/sec: 15587.33
//
Query:       EFC36098.1  [L=470]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0027   18.3   1.0       0.51   11.0   0.0    3.4  3  NID           Nmi/IFP 35 domain (NID)
  ------ inclusion threshold ------
      0.028   13.9   0.0      0.047   13.1   0.0    1.3  1  Orthopox_A5L  Orthopoxvirus A5L protein-like
       0.76    9.9   4.0         13    5.8   0.1    3.0  3  OGG_N         8-oxoguanine DNA glycosylase, N-terminal domain


Domain annotation for each model (and alignments):
>> NID  Nmi/IFP 35 domain (NID)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.24   1.4e+03      39      68 ..      66      94 ..      47     126 .. 0.77
   2 ?    3.3   0.0     0.022   1.3e+02      38      64 ..     235     261 ..     223     273 .. 0.84
   3 !   11.0   0.0   8.6e-05      0.51      19      68 ..     383     432 ..     371     439 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.24
         NID 39 kelkklqvklevskrtvllsgipdvlelde 68
                 +l +l   ++  ++++lls+i +++ +d+
  EFC36098.1 66 YRLLSLCFTTKSNNNSILLSDIGNLT-VDN 94
                55556666777888999999998843.554 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.022
         NID  38 lkelkklqvklevskrtvllsgipdvl 64 
                 l+e ++++ +++ +krt l++gi+++l
  EFC36098.1 235 LQEENEIKYHIHECKRTALIQGIEQLL 261
                 5667789999**************965 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 8.6e-05
         NID  19 khkvelekkkvrvkvspvelkelkklqvklevskrtvllsgipdvlelde 68 
                 ++ v+++ +k+ ++  ++++ + +++  + +++ ++v +++ip++l+ +e
  EFC36098.1 383 NFDVKVDLNKIYIRYMEFDNYMEQSFDFNRNICVERVSVNEIPSILTSNE 432
                 79999***9***********************************986443 PP

>> Orthopox_A5L  Orthopoxvirus A5L protein-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   7.8e-06     0.047      36     119 ..     240     321 ..     214     349 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 7.8e-06
  Orthopox_A5L  36 aieiglksqesyyqrqlreqlardnmlaasrqpiqplqptihitplevPtpaptpkprqqelntssdmsnlfdwlsaddntqps 119
                    i+  ++   +    q +eql ++ +la     i+  qpt +     +   a   k ++q +   s++ n+ +wl+ d n + s
    EFC36098.1 240 EIKYHIHECKRTALIQGIEQLLKKAILA-PITLIHTNQPTFYQERAGILLSASRKKRKKQST-VQSNVINISEWLTIDFNINKS 321
                   445555555566667999*********9.7788999*********99997777666555555.559************998876 PP

>> OGG_N  8-oxoguanine DNA glycosylase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.53   3.2e+03      70      70 ..      78      78 ..      31     149 .. 0.55
   2 ?    4.3   0.1     0.007        42      41      89 ..     233     321 ..     212     333 .. 0.76
   3 ?    5.8   0.1    0.0023        13      79     111 ..     383     415 ..     333     424 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.53
                H CS
       OGG_N 70 e 70
                +
  EFC36098.1 78 N 78
                1 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.007
                 EEEEETTEEEEET--.....................................................HHHHHHTHHHHTTTTS-HHHH CS
       OGG_N  41 eLkqeeddllyrtlesess........................................tkasseeakeeeteeilrdYfnLdvdleel 89 
                 ++ qee+++ y ++e + +                                        +k+ +++++ ++    +++++++d+++++ 
  EFC36098.1 233 TILQEENEIKYHIHECKRTaliqgieqllkkailapitlihtnqptfyqeragillsasRKKRKKQSTVQSNVINISEWLTIDFNINKS 321
                 4556777777777774444788888888888888888888888888888888899888777778888888888899*********9985 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0023
                 HTTTTS-HHHHHHHHTT.SHHHHHHHCCTTT-- CS
       OGG_N  79 YfnLdvdleelykewskkdplfkksadkftGiR 111
                  f+ +vdl+++y + ++ d+ +++s+d+ + i 
  EFC36098.1 383 NFDVKVDLNKIYIRYMEFDNYMEQSFDFNRNIC 415
                 5999**********************9999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (470 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       938  (0.0523175); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2996.95
//
Query:       EFC36099.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-23   81.0  57.5    0.00051   19.9   1.0   10.3 10  LRR_6         Leucine Rich repeat
    5.7e-11   42.5  67.9    0.00024   21.4   7.0    7.0  9  LRR_4         Leucine Rich repeats (2 copies)
    4.4e-09   36.0  41.7    1.6e-05   24.6   6.8    5.4  5  LRR_8         Leucine rich repeat
      0.009   16.4  35.3        4.4    8.2   0.2    8.8  8  LRR_1         Leucine Rich Repeat
  ------ inclusion threshold ------
      0.023   14.5   5.9      0.055   13.3   5.9    1.6  1  PRKCSH-like   Glucosidase II beta subunit-like
       0.37   10.7  18.4      0.081   12.8   1.4    2.4  2  Phage_Mu_Gam  Bacteriophage Mu Gam like protein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.4       5.2   1.5e+04      12      18 ..       3       9 ..       2       9 .. 0.76
   2 !   14.8   0.8   7.1e-06     0.021       4      21 ..      18      35 ..      15      35 .. 0.92
   3 !   18.5   1.1   4.9e-07    0.0015       3      23 ..      41      61 ..      39      62 .. 0.89
   4 !   10.9   0.1   0.00013       0.4       4      24 .]      66      86 ..      63      86 .. 0.92
   5 !    5.4   0.5    0.0077        23       2      14 ..      88     100 ..      87     101 .. 0.88
   6 ?    1.0   0.3      0.19   5.7e+02       9      16 ..     107     114 ..     107     126 .. 0.64
   7 !   19.9   1.0   1.7e-07   0.00051       3      23 ..     129     149 ..     127     150 .. 0.89
   8 !   19.0   0.2   3.3e-07   0.00098       4      23 ..     154     173 ..     151     174 .. 0.91
   9 !   19.9   1.0   1.7e-07   0.00051       3      23 ..     177     197 ..     175     198 .. 0.89
  10 !    9.4   0.2   0.00039       1.2       4      24 .]     202     222 ..     199     222 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 5.2
       LRR_6 12 gNdIgDe 18
                 N+Ig++
  EFC36099.1  3 NNKIGND 9 
                488*985 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 7.1e-06
       LRR_6  4 hLteLdLsgNdIgDeGae 21
                +L++L++s N+Ig+eG++
  EFC36099.1 18 NLKTLNISINNIGNEGLI 35
                8***************85 PP

  == domain 3  score: 18.5 bits;  conditional E-value: 4.9e-07
       LRR_6  3 thLteLdLsgNdIgDeGaeaL 23
                 +Lt L++  NdIgDeG++ +
  EFC36099.1 41 INLTNLNIENNDIGDEGVQDI 61
                58****************876 PP

  == domain 4  score: 10.9 bits;  conditional E-value: 0.00013
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                +Lt L++++N +  +Ga+ ++
  EFC36099.1 66 NLTNLNIKSNALRSKGAQEIS 86
                7****************9885 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.0077
       LRR_6   2 nthLteLdLsgNd 14 
                  t+Lt+L+++ N+
  EFC36099.1  88 LTNLTSLNVAENN 100
                 589*********8 PP

  == domain 6  score: 1.0 bits;  conditional E-value: 0.19
       LRR_6   9 dLsgNdIg 16 
                 +Ls N+I+
  EFC36099.1 107 NLSRNNIT 114
                 56777765 PP

  == domain 7  score: 19.9 bits;  conditional E-value: 1.7e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt L+++ NdIgDeG++ +
  EFC36099.1 129 INLTNLNIQNNDIGDEGVQDI 149
                 58****************876 PP

  == domain 8  score: 19.0 bits;  conditional E-value: 3.3e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt Ld+  N+I DeG++++
  EFC36099.1 154 NLTNLDIGNNKIRDEGIKSI 173
                 8*****************98 PP

  == domain 9  score: 19.9 bits;  conditional E-value: 1.7e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt L+++ NdIgDeG++ +
  EFC36099.1 177 INLTNLNIQNNDIGDEGVQDI 197
                 58****************876 PP

  == domain 10  score: 9.4 bits;  conditional E-value: 0.00039
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt Ld+   +IgD Ga+ ++
  EFC36099.1 202 NLTNLDICQTKIGDNGAKEIC 222
                 89****************998 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   4.2   0.00011      0.34      10      36 ..       3      29 ..       1      35 [. 0.86
   2 !   13.0   8.0   3.5e-05      0.11       2      39 ..      18      53 ..      17      63 .. 0.81
   3 !   11.6   6.7   9.6e-05      0.29       2      33 ..      42      75 ..      41      79 .. 0.87
   4 !   13.4   5.2   2.7e-05     0.082       2      34 ..      66     100 ..      65     104 .. 0.87
   5 !    8.9   6.5   0.00068         2       7      39 ..     107     141 ..     107     152 .. 0.77
   6 !   21.4   7.0   8.1e-08   0.00024       2      38 ..     130     167 ..     129     175 .. 0.90
   7 !   19.3   7.4   3.7e-07    0.0011       2      39 ..     154     189 ..     153     200 .. 0.84
   8 !   15.2   4.4     7e-06     0.021       2      37 ..     178     214 ..     177     217 .. 0.84
   9 !   10.8   4.5   0.00017      0.52       2      36 ..     202     243 ..     201     256 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00011
                SS---.E-S-HHH-TT--EEE-.-S--- CS
       LRR_4 10 nNqlt.diplleklpnLkeLdLsgNnli 36
                nN++  d++ ++kl nLk+L++s N +i
  EFC36099.1  3 NNKIGnDVQDISKLVNLKTLNISIN-NI 29
                899**99999999*********666.44 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 3.5e-05
                S--EEE--SS---E-S-HH..H-TT--EEE-.-S-----G CS
       LRR_4  2 nLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitdl 39
                nL++L++s N++   +l+   +l nL+ L++ +N    d+
  EFC36099.1 18 NLKTLNISINNIGNEGLIIvcNLINLTNLNIENN----DI 53
                9*******88***777733567*********666....55 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 9.6e-05
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33
                nL++L++ nN + d +   ++kl nL+ L++ +N
  EFC36099.1 42 NLTNLNIENNDIGDEGVqdISKLVNLTNLNIKSN 75
                9*************99987778*********666 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 2.7e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 nL++L++ +N l++ +   ++kl+nL++L++ +Nn
  EFC36099.1  66 NLTNLNIKSNALRSKGAqeISKLTNLTSLNVAENN 100
                 9************866666558*********8885 PP

  == domain 5  score: 8.9 bits;  conditional E-value: 0.00068
                 E--SS---.E-S-......HHH-TT--EEE-.-S-----G CS
       LRR_4   7 dLsnNqlt.dipl......leklpnLkeLdLsgNnlitdl 39 
                 +Ls N++t  i++      + +l nL+ L++ +N    d+
  EFC36099.1 107 NLSRNNIThQIENdgiksiF-NLINLTNLNIQNN----DI 141
                 79999***999996654433.6*********555....44 PP

  == domain 6  score: 21.4 bits;  conditional E-value: 8.1e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 nL++L+++nN + d +   ++kl nL+ Ld+ gNn+i+d
  EFC36099.1 130 NLTNLNIQNNDIGDEGVqdISKLINLTNLDI-GNNKIRD 167
                 9*************99987778*********.999**87 PP

  == domain 7  score: 19.3 bits;  conditional E-value: 3.7e-07
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitdl 39 
                 nL++Ld++nN+++d +    ++ l nL+ L++ +N    d+
  EFC36099.1 154 NLTNLDIGNNKIRDEGIksiFN-LINLTNLNIQNN----DI 189
                 9*************99987666.*********555....44 PP

  == domain 8  score: 15.2 bits;  conditional E-value: 7e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 nL++L+++nN + d +   ++kl nL+ Ld+ +  +i+
  EFC36099.1 178 NLTNLNIQNNDIGDEGVqdISKLINLTNLDICQT-KIG 214
                 9*************99987778********9554.554 PP

  == domain 9  score: 10.8 bits;  conditional E-value: 0.00017
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S.....--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN.....nli 36 
                 nL++Ld+ ++++ d +   + kl nL++L +++      n+i
  EFC36099.1 202 NLTNLDICQTKIGDNGAkeICKLINLTKLVCWNTdiatnNQI 243
                 9*************99965338********866522222565 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   6.7    0.0033       9.9      11      61 .]       4      53 ..       1      53 [. 0.80
   2 !   24.6   6.8   5.3e-09   1.6e-05       2      60 ..      42     100 ..      41     101 .. 0.97
   3 !    5.0   3.7    0.0069        21      31      61 .]     107     141 ..     107     141 .. 0.79
   4 !   19.0   9.4   2.8e-07   0.00085       2      61 .]     130     189 ..     129     189 .. 0.98
   5 !    9.0   2.1   0.00038       1.1       2      54 ..     178     230 ..     177     232 .. 0.92

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0033
                S--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8 11 NrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                N++ +  ++  k l nLk+L++s N++         +L +L+ L++++N++
  EFC36099.1  4 NKIGNDVQDISK-LVNLKTLNISINNIGNEGLIIVCNLINLTNLNIENNDI 53
                555555555555.99999999999999999999999999999999999987 PP

  == domain 2  score: 24.6 bits;  conditional E-value: 5.3e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 nLt+L++ nN + + + +  ++l nL+ L++++N l++  ++ +s L++L+sL++  N+
  EFC36099.1  42 NLTNLNIENNDIGDEGVQDISKLVNLTNLNIKSNALRSKGAQEISKLTNLTSLNVAENN 100
                 8******************************************************9997 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0069
                 E--SS---G.GGGG...GGTT--S-.EEE--SS-- CS
       LRR_8  31 dLsnNlltt.lspg...afsgLpsLrsLdLsgNrL 61 
                 +Ls+N++t+ ++++   ++ +L +L+ L++++N++
  EFC36099.1 107 NLSRNNITHqIENDgikSIFNLINLTNLNIQNNDI 141
                 79999999988876333677899999999999987 PP

  == domain 4  score: 19.0 bits;  conditional E-value: 2.8e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+L+++nN + + + +  ++l nL+ Ld++nN+++    +++ +L +L+ L++++N++
  EFC36099.1 130 NLTNLNIQNNDIGDEGVQDISKLINLTNLDIGNNKIRDEGIKSIFNLINLTNLNIQNNDI 189
                 8*************************************9999****************97 PP

  == domain 5  score: 9.0 bits;  conditional E-value: 0.00038
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsL 54 
                 nLt+L+++nN + + + +  ++l nL+ Ld+ + ++    ++ +  L +L++L
  EFC36099.1 178 NLTNLNIQNNDIGDEGVQDISKLINLTNLDICQTKIGDNGAKEICKLINLTKL 230
                 8**********************************999888888888888877 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.6      0.05   1.5e+02       1      12 [.      18      29 ..      18      39 .. 0.76
   2 !    8.2   0.2    0.0015       4.4       1      23 []      42      64 ..      42      64 .. 0.90
   3 ?    2.2   0.1      0.14   4.3e+02       1      23 []      66      88 ..      66      88 .. 0.85
   4 ?    2.2   0.4      0.14   4.3e+02       1      13 [.      90     114 ..      90     125 .. 0.53
   5 !    6.9   0.2    0.0041        12       1      23 []     130     152 ..     130     152 .. 0.90
   6 !    6.3   0.3    0.0063        19       1      22 [.     154     175 ..     154     176 .. 0.84
   7 !    6.9   0.2    0.0041        12       1      23 []     178     200 ..     178     200 .. 0.90
   8 ?    0.7   0.2      0.43   1.3e+03       1      22 [.     202     223 ..     202     249 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.05
       LRR_1  1 nLrhLdLsnnpl 12
                nL++L++s n++
  EFC36099.1 18 NLKTLNISINNI 29
                8******88876 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0015
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                nL+ L+++nn +++ + +++++L
  EFC36099.1 42 NLTNLNIENNDIGDEGVQDISKL 64
                89**********99999988876 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.14
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                nL+ L++ +n l +++++ +++L
  EFC36099.1 66 NLTNLNIKSNALRSKGAQEISKL 88
                899*******9988888877765 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.14
       LRR_1   1 nLrhLd............Lsnnpll 13 
                 nL++L+            Ls+n+++
  EFC36099.1  90 NLTSLNvaennvmlseknLSRNNIT 114
                 7888983333333222224666664 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0041
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ L++ nn +++ + +++++L
  EFC36099.1 130 NLTNLNIQNNDIGDEGVQDISKL 152
                 89**********99999988876 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.0063
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL+ Ld++nn + + ++ s+ n
  EFC36099.1 154 NLTNLDIGNNKIRDEGIKSIFN 175
                 89*********98888887765 PP

  == domain 7  score: 6.9 bits;  conditional E-value: 0.0041
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ L++ nn +++ + +++++L
  EFC36099.1 178 NLTNLNIQNNDIGDEGVQDISKL 200
                 89**********99999988876 PP

  == domain 8  score: 0.7 bits;  conditional E-value: 0.43
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL+ Ld+++  +++ ++  +++
  EFC36099.1 202 NLTNLDICQTKIGDNGAKEICK 223
                 7899999887775555555544 PP

>> PRKCSH-like  Glucosidase II beta subunit-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   5.9   1.9e-05     0.055      98     175 ..     208     292 ..     197     293 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.9e-05
  PRKCSH-like  98 vcdydiccdGsde.......elgkcenkcaeiarkfeelleeankkvkkglkikeelllaakkkldelkkklkeledslkakkkr 175
                  +c  +i  +G+ e       ++ +c n+    +++++ l++e+n+k+k+glk k + ll+ k+ +++ ++++k+ +d+lk+++++
   EFC36099.1 208 ICQTKIGDNGAKEicklinlTKLVCWNTDIATNNQINILKNEKNQKLKSGLKEKYNKLLEIKQANEKAIQNYKNQNDNLKNENEE 292
                  67777777777776644444567899999999***********************************************998765 PP

>> Phage_Mu_Gam  Bacteriophage Mu Gam like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   8.3    0.0097        29      19      78 ..     241     300 ..     237     302 .. 0.81
   2 ?   12.8   1.4   2.7e-05     0.081      17      62 ..     303     348 .]     295     348 .] 0.91

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0097
                   HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCTHHHH-...-----EE-SS CS
  Phage_Mu_Gam  19 eeieaeaneeiaaikekleaeleplkkeieylesllkqYaeankdeLf.kdgktKslklpf 78 
                   ++i+   ne+ +++k  l+++ ++l + +++ e++++ Y  +n  +L+ ++++ Ks   +f
    EFC36099.1 241 NQINILKNEKNQKLKSGLKEKYNKLLEIKQANEKAIQNYKNQND-NLKnENEELKSQLCAF 300
                   6889999999*****************************99999.6651455666665555 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 2.7e-05
                   HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCTH CS
  Phage_Mu_Gam  17 eleeieaeaneeiaaikekleaeleplkkeieylesllkqYaeank 62 
                   e+ ++++++++ i++++ ++e+el+++k e e+  ++l+ + e++ 
    EFC36099.1 303 EIIQMQSKYKKFIEKLTTDHETELKKMKLENEKKVKMLEFWLESHN 348
                   778899************************************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2104  (0.117352); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.42
# Mc/sec: 2465.06
//
Query:       EFC36100.1  [L=193]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.32   11.1   1.7          9    6.4   0.0    3.0  3  DUF2129   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF2129  Uncharacterized protein conserved in bacteria (DUF2129)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.012   2.1e+02      33      53 ..      21      41 ..      17      45 .. 0.85
   2 ?   -0.5   0.1     0.073   1.3e+03      39      55 ..     110     126 ..     104     129 .. 0.82
   3 ?    6.4   0.0    0.0005         9      39      64 ..     166     191 ..     163     193 .] 0.88

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.012
     DUF2129 33 vvlYvneedveeiveklkklk 53
                vv+Y ++ +++++ ekl    
  EFC36100.1 21 VVMYNEKRELSDLSEKLAPCT 41
                89**************98665 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.073
     DUF2129  39 eedveeiveklkklkfV 55 
                 ++++e++v++++k   V
  EFC36100.1 110 KQNIEQLVNEIQKTGQV 126
                 57899999999987666 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0005
     DUF2129  39 eedveeiveklkklkfVkkVerSerp 64 
                 ++ +e+++e++++ +fV +V  S+ +
  EFC36100.1 166 DKTLEKTIEHINTCSFVLNVLFSKSK 191
                 6789****************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (193 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1217  (0.0678789); expected 358.6 (0.02)
Passed bias filter:                      632  (0.0352502); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1212.28
//
Query:       EFC36101.1  [L=206]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (206 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2899  (0.161693); expected 358.6 (0.02)
Passed bias filter:                      754  (0.0420548); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 1354.51
//
Query:       EFC36102.1  [L=406]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.1e-06   28.1   0.1    1.1e-06   28.1   0.1    2.0  2  SWIM       SWIM zinc finger
    0.00014   22.1  12.3    0.00014   22.1  12.3    2.2  3  zf-RING_2  Ring finger domain
    0.00052   19.9   0.0    0.00096   19.0   0.0    1.4  1  Rho_N      Rho termination factor, N-terminal domain
  ------ inclusion threshold ------
      0.042   13.6   0.6        2.8    7.8   0.0    2.4  2  SAP        SAP domain
       0.21   11.7  11.6       0.65   10.2  11.6    1.9  1  RINGv      RING-variant domain
        2.3    8.2  13.9        5.2    7.0  13.9    1.7  1  PHD        PHD-finger


Domain annotation for each model (and alignments):
>> SWIM  SWIM zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.1   0.1   3.7e-10   1.1e-06       1      39 [.     193     224 ..     193     225 .. 0.91
   2 ?   -3.3   1.0       2.6   7.9e+03      11      21 ..     296     306 ..     291     313 .. 0.71

  Alignments for each domain:
  == domain 1  score: 28.1 bits;  conditional E-value: 3.7e-10
        SWIM   1 yrVtlddervrlnkatCsCpefqkngipCkHalAvllal 39 
                 y V +++      + +C Cp+ + ng +CkH+l vll++
  EFC36102.1 193 YDVVIGE------EPSCNCPDAE-NGNLCKHVLFVLLKV 224
                 7888885......9*********.************975 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.6
        SWIM  11 rlnkatCsCpe 21 
                 + +  +C C+ 
  EFC36102.1 296 QKEAGYCHCCG 306
                 55677898884 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       4.9   1.5e+04      38      42 ..     150     154 ..     138     154 .. 0.61
   2 ?   -3.8   0.0         6   1.8e+04      21      25 ..     214     219 ..     208     219 .. 0.75
   3 !   22.1  12.3   4.8e-08   0.00014       2      44 .]     282     330 ..     281     330 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.9
   zf-RING_2  38 stCPl 42 
                 s+CP+
  EFC36102.1 150 SSCPI 154
                 33875 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 6
   zf-RING_2  21 CgHv.f 25 
                 C+Hv f
  EFC36102.1 214 CKHVlF 219
                 999855 PP

  == domain 3  score: 22.1 bits;  conditional E-value: 4.8e-08
   zf-RING_2   2 eCpICleelssads...vlllpCgHv.fhreClerwlrssst..CPlCr 44 
                 +CpIC++ +s+ d+   +  ++C+ v  h +Cl+ w   +++  CP+C+
  EFC36102.1 282 NCPICCDGFSQLDEqkeAGYCHCCGVnVHADCLKAWKGFNKEypCPICK 330
                 7*****888554443344355566665*********88888888****7 PP

>> Rho_N  Rho termination factor, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.0   3.2e-07   0.00096       1      36 [.      25      61 ..      25      62 .. 0.93

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 3.2e-07
                HHHHS-HHHHHHHHHHTT-.TTGGGS-HHHHHHHHHH CS
       Rho_N  1 eLkektlseLraiAkelgi.enysrlRKqdLIfaIlk 36
                +L ++t+ +L++  k+lgi  + s lRK +LI++I++
  EFC36102.1 25 DLWALTVDQLKQHMKDLGIyHGCSHLRKEELIEKIKE 61
                56789**************99**************86 PP

>> SAP  SAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0   0.00093       2.8       4      18 ..      29      43 ..      28      43 .. 0.93
   2 ?    3.6   0.2     0.019        57      23      34 ..      51      62 ..      50      63 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00093
                --HHHHHHHHHHTT- CS
         SAP  4 ltVaeLKeeLkkrGL 18
                ltV++LK+ +k +G+
  EFC36102.1 29 LTVDQLKQHMKDLGI 43
                9***********996 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.019
                -HHHHHHHHHHH CS
         SAP 23 kKaeLieRLkey 34
                +K+eLie +ke+
  EFC36102.1 51 RKEELIEKIKEF 62
                6*********98 PP

>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2  11.6   0.00022      0.65       1      48 []     283     329 ..     283     329 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00022
                 ETTTTEE-SSSS..--B-SS--STCCCSB-HHHHHHHHHHTCT-SB-TTT CS
       RINGv   1 CriCleeeeese..plispCkCrGslklvHesClekWldekeantqCeiC 48 
                 C iC ++ ++ +  +    C+C G    vH +Cl+ W    +++  C iC
  EFC36102.1 283 CPICCDGFSQLDeqKEAGYCHCCG--VNVHADCLKAWKGF-NKEYPCPIC 329
                 8888887665443456779*****..78**********99.999****** PP

>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0  13.9    0.0018       5.2       2      51 ..     283     331 ..     282     332 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0018
                 BTTTTS...TTSTTSCEEEETTTSCEEETTTSSSTHSHHSHHSSTBSSTTTHT CS
         PHD   2 CavCkk...ksdeeeelvqCdgCkrwfHqkClkppleseekpegewlCekCke 51 
                 C +C +   + de++e  +C+ C+  +H +Clk  +      ++e+ C+ Ck 
  EFC36102.1 283 CPICCDgfsQLDEQKEAGYCHCCGVNVHADCLKAWKG----FNKEYPCPICKA 331
                 888877799999*********************9966....44479*****86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (406 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1694  (0.0944838); expected 358.6 (0.02)
Passed bias filter:                      508  (0.028334); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2494.51
//
Query:       EFC36103.1  [L=490]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.6e-34  117.6   0.0    9.7e-34  117.1   0.0    1.2  1  FAD-oxidase_C  FAD linked oxidases, C-terminal domain
      4e-33  114.1   0.0    7.7e-33  113.2   0.0    1.4  1  FAD_binding_4  FAD binding domain


Domain annotation for each model (and alignments):
>> FAD-oxidase_C  FAD linked oxidases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.1   0.0   1.1e-37   9.7e-34       2     221 ..     240     482 ..     239     486 .. 0.95

  Alignments for each domain:
  == domain 1  score: 117.1 bits;  conditional E-value: 1.1e-37
                    -SEEEEEEEEESSHHHHHHHHHHHHHHT---SEEEEE-HHHHHHHHHTS-SS...................TTS-TTT-EEEEEEEEE-HHHHHHH CS
  FAD-oxidase_C   2 pearavalvafpsfeaavkavreiaqagiipaalelmdkkaldlveatkgak...................kglpdeeealllvefegddeeeaee 78 
                    pe +++++v +p+fea+v++++e+  +++ pa+++l+d+ ++++++++k+++                    g+++e+ +++++ feg++++ +++
     EFC36103.1 240 PECQVYGSVLVPDFEAGVACLHEVSNRRVAPASIRLIDNSQFQFGQSLKPKQeskleglsdwfkglyvtkgCGFDKEKMCVITLLFEGSQSDIDRQ 335
                    78899*****************************************************************99***********************9 PP

                    HHHH.HHHHTTT-EEEEE..........ETGGGGGGGGHHHHHHHHHCTTEEEEEEEEEEEHHHHHHHHHHHHHHHHHHH........EEEEEEEE CS
  FAD-oxidase_C  79 elea.lveaileatgaadvlvaqdeaeaealwkaRkaalpylrdallkagvavlseDtsvPvsrladlvrdikalldkyg........levvlfgH 165
                    +    +++a+ ++ +a+         ea  + ++ +++++ylrd + +++ + +s++ts P+sr+  ++++++++++++         ++ +++++
     EFC36103.1 336 QKIIyDITAKYGGLVAGA--------EAGYRGYLLTYVIAYLRDYGFNYYFMSESFETSAPWSRVVPMIKKVEERVKESAkqrnvptpWVSARVTQ 423
                    999999999999999998........66699***************************************************************** PP

                    EETTEEEEEEEEEEE..--TT--THHHHHH....HHHHHHTT------------------ CS
  FAD-oxidase_C 166 agdgnlhlyilfdladeaeeeraeklvdev....vdlavelgGsisgEHGvGldkkayle 221
                    +++ ++++y+++ +  ++ ++++ k++ e+    +d+++  gGs+s++HGvG+ +k+++ 
     EFC36103.1 424 VYETGACIYFYYGFIFRGLQDPI-KAFSEIeaeaRDEILLQGGSLSHHHGVGKLRKEWMS 482
                    **************999999988.5555555777************************97 PP

>> FAD_binding_4  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.2   0.0   8.6e-37   7.7e-33       2     135 ..      59     200 ..      58     201 .. 0.93

  Alignments for each domain:
  == domain 1  score: 113.2 bits;  conditional E-value: 8.6e-37
                    EEEEEESSHHHHHHHHHHHHHC..TSCEEEESSSTTEE.STTC....SCCEEEEEETTS--EEEEETTTTEEEEETTSBHHHHHHHHHHH.TTECS CS
  FAD_binding_4   2 aavvrpeseeevaaalrlanea..glpvlvrGgGssll.gqav....atggvvldlsrlnrileideeegtatveaGvtlgdlvealaak.glllg 89 
                    ++v++p s+e+v++++ la+++  +l+++++GgG++++    +    ++  v +dl+++n+il++d + +tat+++G+++ dl+++l++k +l+lg
     EFC36103.1  59 DVVIYPNSHEHVEKIVSLATKYsnELTLIPYGGGTNVTqALLCpeneTRMIVSVDLQEMNKILNVDMTCHTATIQSGAIGIDLQQELKQKyNLTLG 154
                    79******************9977899***********555558776666699***99*****************************98779**** PP

                    SGGGTTCGSBHHHTTTTT-EETTEEGG--HHGTEEEEEEEETTSEE CS
  FAD_binding_4  90 lepgsgipgtvGGaiatnagGygsekyGlirdnvlglevvladGev 135
                    +ep s++ +++GG+iat+a+G+  + yG+i+d+++++++v+++G++
     EFC36103.1 155 HEPDSIEFSSLGGWIATRASGMKKNEYGNIEDMLVNVKIVTPKGTW 200
                    ********************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (490 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.23s 00:00:00.76 Elapsed: 00:00:00.41
# Mc/sec: 3562.02
//
Query:       EFC36104.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-13   51.2   5.6    1.3e-13   51.2   5.6    2.6  2  RGS              Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.066   12.9   1.6      0.073   12.8   0.1    1.8  3  Cation_ATPase_C  Cation transporting ATPase, C-terminus


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.2   5.6   1.5e-17   1.3e-13       2     118 .]      31     202 ..      30     202 .. 0.93
   2 ?   -1.2   0.1      0.26   2.3e+03       7      22 ..     267     283 ..     264     288 .. 0.58

  Alignments for each domain:
  == domain 1  score: 51.2 bits;  conditional E-value: 1.5e-17
                 HHHHHTSHHHHHHHHHHHHHTTCT.HHHHHHHHHHHHHTS..SHHHHHHHH.HHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS............. CS
         RGS   2 leslledqpgrslFreFlesefse.enlsFwlaveefkka..keqeelkkk.akeIyneylapsspkelnidkklreelekrleke............. 83 
                 +++++ +q  ++lF+eFl ++ ++ e++ F+++v efk+   +   el++k a++I+++++  +s++e+ni k+ r+++ +r++               
  EFC36104.1  31 FDKVILNQRTMKLFKEFLMKSLHSpEAILFYEKVLEFKSFegQALTELQTKlAQNIVERFIVVGSAHEINIGKRERNQVLERVKRLlgnspqncelkhv 129
                 7889999**********99888888*************99553333444446*******************************9999************ PP

                 ......................................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS  84 ......................................qpsrklfeeaqeevfellekdsypkFlkselylrl 118
                                                           ++f+ea   v + l++d +p Fl+s+ +l++
  EFC36104.1 130 snskqmlnkkenesdehsetstnkqtsfsmsetstfimVDPINIFDEALVTVKRQLKEDVFPLFLRSDRFLTF 202
                 **************************************999****************************9975 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.26
                 TSHH.HHHHHHHHHHHT CS
         RGS   7 edqp.grslFreFlese 22 
                 e+++  +s+F +F+ se
  EFC36104.1 267 EQEYfKKSCFATFVSSE 283
                 55555556666666554 PP

>> Cation_ATPase_C  Cation transporting ATPase, C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0      0.79   7.1e+03      86     105 ..     151     175 ..     133     201 .. 0.61
   2 ?   -3.6   0.0      0.87   7.8e+03      86     102 ..     264     283 ..     244     288 .. 0.66
   3 ?   12.8   0.1   8.1e-06     0.073     153     181 ..     316     344 ..     308     345 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 0.79
  Cation_ATPase_C  86 s.....snyaqtmaFitlvlsqifn 105
                            +++  t++Fi++  ++if+
       EFC36104.1 151 TnkqtsFSMSETSTFIMVDPINIFD 175
                      0344446667777777665555555 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 0.87
  Cation_ATPase_C  86 s...snyaqtmaFitlvlsq 102
                          ++y+  + F t+v s+
       EFC36104.1 264 TlleQEYFKKSCFATFVSSE 283
                      13446777888888888776 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 8.1e-06
  Cation_ATPase_C 153 gtaplsleewlialllalvvllvdelvKl 181
                      +t pl++++w+i++ +++++++++ lv++
       EFC36104.1 316 KTIPLNWYQWAITISIGFISIPYGFLVRF 344
                      799********************999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1382  (0.0770818); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2284.64
//
Query:       EFC36105.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.6e-15   55.5   0.0      1e-14   54.7   0.0    1.4  1  OB_NTP_bind  Oligonucleotide/oligosaccharide-binding (OB)-fol
    3.1e-13   49.9   0.0    5.7e-13   49.1   0.0    1.5  1  HA2          Helicase associated domain (HA2)
  ------ inclusion threshold ------
      0.085   12.6   0.1       0.26   11.0   0.1    1.8  1  UPF0730      UPF0730 unknown protein family


Domain annotation for each model (and alignments):
>> OB_NTP_bind  Oligonucleotide/oligosaccharide-binding (OB)-fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.7   0.0   1.7e-18     1e-14       1      81 [.     124     201 ..     124     203 .. 0.93

  Alignments for each domain:
  == domain 1  score: 54.7 bits;  conditional E-value: 1.7e-18
                  HHHHHHHHHTTCEEEEEETTCCEEETTTCEEEEE-TTSTTTTT...TSSSEEEEEEEEESSSEEEEEEEEE-HHHHHHHST CS
  OB_NTP_bind   1 lraillaGlypqiarkdpskkdyktartktrvfihpsSvlaknekekepewvvytelvettklylrdltaidpawLllfag 81 
                  +r+++++G++ + a  +  ++ y  ++t+ ++++hp+S+l    +  +p++vvy+elv ttk y+  +ta++  wL+++a+
   EFC36105.1 124 VRKAICSGYFHHAATLKGIGE-YVNMMTGMPCSLHPTSALYG--MGYTPDFVVYHELVMTTKEYILISTAVEGSWLAELAP 201
                  69************9999998.666668*************6..88*********************************98 PP

>> HA2  Helicase associated domain (HA2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.1   0.0   9.6e-17   5.7e-13      24     108 .]       1      66 [.       1     105 [. 0.82

  Alignments for each domain:
  == domain 1  score: 49.1 bits;  conditional E-value: 9.6e-17
         HA2  24 maelPlsprlakmLlaaaeleegcldevitivAalsveeifleeneeekeeeeeeeekakkkrkeeekarrklahkdaegDhltl 108
                 m+elPl+p l+kmL+++ +l  gc++ev+tiv++lsv  +f ++++ e+e ++                r+k+  ++  +Dhltl
  EFC36105.1   1 MVELPLDPPLSKMLIYSEKL--GCTSEVLTIVSMLSVPTVFYRPKDREEEADA------V---------REKFFVAE--SDHLTL 66 
                 99***************666..*********************9976644332......1.........22222233..666664 PP

>> UPF0730  UPF0730 unknown protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   4.4e-05      0.26      22      34 ..     158     170 ..     155     175 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 4.4e-05
     UPF0730  22 senalYGvGYsss 34 
                 + +alYG+GY+ +
  EFC36105.1 158 PTSALYGMGYTPD 170
                 789*******975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       529  (0.0295053); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1467.43
//
Query:       EFC36106.1  [L=310]
Description: hypothetical protein NAEGRDRAFT_76225 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-22   80.2   0.0    1.8e-22   79.5   0.0    1.4  1  CH        Calponin homology (CH) domain
    5.2e-08   32.4   4.0    9.3e-08   31.6   4.0    1.4  1  SHOCT     Short C-terminal domain


Domain annotation for each model (and alignments):
>> CH  Calponin homology (CH) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5   0.0   2.1e-26   1.8e-22       2     108 ..      38     142 ..      37     143 .. 0.92

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 2.1e-26
                 HHHHHHHHHHHHHHTTSTTSSTTSCHHHHHTTSHHHHHHHHHHSTTTSSGGGSTTTHHHHHHHHHHHHHHHHHHTTCHTTSS.-HHHHHTTSHH.HHHH CS
          CH   2 eqkkellrWinshleeagpkvkvedfeedlrDGvlLckLlnklapglvdkkklnksefkkleNinlaldvaekklgvpkvli.eaedlvegknk.svlt 98 
                 + +ke+++Wi+++++ + ++   +df+e+l+DGvlLckL+nk++pg v+  +  k +f ++eNi ++l++a+ +lg+++ ++  ++dl+egkn  +v+ 
  EFC36106.1  38 QKEKEVRQWIEAVTGTKFSS---NDFQESLKDGVLLCKLANKIKPGIVKTINSGKMPFMCMENIGYFLKAAA-ELGLDTHNTfMSVDLYEGKNIpLVIM 132
                 5799**********886544...7***********************999999888*************888.************************** PP

                 HHHHHHHHHH CS
          CH  99 llaqLfrafq 108
                  l+++ ++ q
  EFC36106.1 133 ALYSFGSVVQ 142
                 ***9988765 PP

>> SHOCT  Short C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.6   4.0     1e-11   9.3e-08       1      28 []     281     308 ..     281     308 .. 0.98

  Alignments for each domain:
  == domain 1  score: 31.6 bits;  conditional E-value: 1e-11
       SHOCT   1 daLekLkeLyarGeIteEEFeakKakLL 28 
                 d+LekL  L+++G+Ite EF+ kK++LL
  EFC36106.1 281 DELEKLGNLRDKGIITEREFQLKKKQLL 308
                 89*************************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 2093.69
//
Query:       EFC36107.1  [L=459]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.7e-43  144.9   4.2    1.5e-14   53.4   0.0    4.4  4  Prenyltrans      Prenyltransferase and squalene oxidase repea
  ------ inclusion threshold ------
      0.012   14.7   0.0      0.027   13.6   0.0    1.6  1  SQHop_cyclase_C  Squalene-hopene cyclase C-terminal domain
      0.024   13.7   0.0         10    5.1   0.0    2.9  3  SQHop_cyclase_N  Squalene-hopene cyclase N-terminal domain


Domain annotation for each model (and alignments):
>> Prenyltrans  Prenyltransferase and squalene oxidase repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   0.0   3.3e-09     2e-05       1      43 [.      64     107 ..      64     108 .. 0.95
   2 !   46.3   0.1   4.2e-16   2.5e-12       2      44 .]     119     161 ..     118     161 .. 0.97
   3 !   53.4   0.0   2.6e-18   1.5e-14       1      43 [.     180     222 ..     180     223 .. 0.97
   4 !   19.6   0.3   9.3e-08   0.00056       5      31 ..     232     258 ..     228     258 .. 0.91

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 3.3e-09
                  HHHHHHHHHHHHHSH.TTS-BBSSTTSSBBHHHHHHHHHHHHHC CS
  Prenyltrans   1 idvekavefLlscQn.edGGwggrpgsesdtyytywalaaLall 43 
                  +++e +++f++   + + GG++g p+++++  yt+ a++ L ll
   EFC36107.1  64 MNREHILQFIRDSYHaDVGGFAGAPNHDAHILYTLSAVQLLVLL 107
                  68999**********************************99886 PP

  == domain 2  score: 46.3 bits;  conditional E-value: 4.2e-16
                  HHHHHHHHHHHHSHTTS-BBSSTTSSBBHHHHHHHHHHHHHCT CS
  Prenyltrans   2 dvekavefLlscQnedGGwggrpgsesdtyytywalaaLallG 44 
                   +ek+ ef+ s Q edG+++g+ ++e dt+++y+al++LallG
   EFC36107.1 119 QIEKIGEFIGSLQKEDGSFSGDKWGEIDTRFSYCALNCLALLG 161
                  58****************************************8 PP

  == domain 3  score: 53.4 bits;  conditional E-value: 2.6e-18
                  HHHHHHHHHHHHHSHTTS-BBSSTTSSBBHHHHHHHHHHHHHC CS
  Prenyltrans   1 idvekavefLlscQnedGGwggrpgsesdtyytywalaaLall 43 
                  i+vek v+++lscQn dGG+g +pg es++++ ++++ aL+++
   EFC36107.1 180 INVEKTVDYVLSCQNFDGGFGVCPGAESHAGQIFTCVGALSIA 222
                  79***************************************97 PP

  == domain 4  score: 19.6 bits;  conditional E-value: 9.3e-08
                  HHHHHHHHHSHTTS-BBSSTTSSBBHH CS
  Prenyltrans   5 kavefLlscQnedGGwggrpgsesdty 31 
                  ++ ++L+ +Q+e GG++grp++ sd++
   EFC36107.1 232 TLSWWLCERQCENGGLNGRPEKLSDVF 258
                  6779*********************85 PP

>> SQHop_cyclase_C  Squalene-hopene cyclase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   4.5e-06     0.027     152     229 ..     111     202 ..      87     222 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 4.5e-06
                      HT--TTSHHHHHHHHHHHHHS-TTS----.SSB...SSHHHHHHHHHHHHHHTT..--......TTSHH..HHHHHHHHHTT--TTSSBB-- CS
  SQHop_cyclase_C 152 lgeeedsealkraveylkkeqepdGsWfG.rWG...vnyiyGtwsvlsalaavg..ed......leepv..irkavdWlksvqnedGGWGes 229
                      ++e  + e++++  e++ + q++dGs+ G +WG   + + y + ++l  l  ++  ++      +++++  ++k+vd++ s qn dGG+G +
       EFC36107.1 111 IEEFLTLEQIEKIGEFIGSLQKEDGSFSGdKWGeidTRFSYCALNCLALLGLLEtcSNyrgdkiNNKKYinVEKTVDYVLSCQNFDGGFGVC 202
                      44446778899999*************98679844456778877766544333211221222333344422689***************964 PP

>> SQHop_cyclase_N  Squalene-hopene cyclase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.28   1.7e+03      40      80 ..      59     100 ..      55     102 .. 0.82
   2 ?    5.1   0.0    0.0017        10      33      88 ..     105     161 ..      95     169 .. 0.77
   3 ?    5.1   0.0    0.0017        10      46      78 ..     181     216 ..     172     225 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.28
  SQHop_cyclase_N  40 geddeeeeekiakylrsqqred.GgWelypggpgdlsttvea 80 
                       e ++ ++e+i +++r++ ++d Gg++ +p++++++  t  a
       EFC36107.1  59 SESSKMNREHILQFIRDSYHADvGGFAGAPNHDAHILYTLSA 100
                      56677789999999*999996669****99999999988766 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0017
  SQHop_cyclase_N  33 illrefl.geddeeeeekiakylrsqqredGgWelypggpgdlsttveaYlALkllG 88 
                      +ll   + +  + e++eki +++ s q+edG+++  + g+ d  ++  a   L llG
       EFC36107.1 105 VLLTSNIeEFLTLEQIEKIGEFIGSLQKEDGSFSGDKWGEIDTRFSYCALNCLALLG 161
                      455555545667899******************987777777777766666666666 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0017
  SQHop_cyclase_N  46 eeekiakylrsqqredGgWelypggp...gdlsttv 78 
                      + ek++ y++s q+ dGg++++pg +   g+++t v
       EFC36107.1 181 NVEKTVDYVLSCQNFDGGFGVCPGAEshaGQIFTCV 216
                      678999****************98762335666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1423  (0.0793686); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.68u 0.37s 00:00:01.05 Elapsed: 00:00:00.57
# Mc/sec: 2444.56
//
Query:       EFC36108.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-36  126.4   0.1    2.8e-36  125.2   0.1    1.6  1  Pro_CA    Carbonic anhydrase
  ------ inclusion threshold ------
        1.1    7.8   5.2        1.2    7.6   5.2    1.1  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> Pro_CA  Carbonic anhydrase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  125.2   0.1   3.2e-40   2.8e-36       1     102 [.     175     272 ..     175     288 .. 0.92

  Alignments for each domain:
  == domain 1  score: 125.2 bits;  conditional E-value: 3.2e-40
                 EEEEEETTTTS-HHHHTTS-TTSEEEEEETTG---TT-HHHHHHHHHHHHTS--SEEEEEEETT-HHHHHHHSHHCCSTTSSHHHHHHHHHHHHHHHCH CS
      Pro_CA   1 alvigCsDSRvppelitdagpGdlFvvrnvgnlvppadssvlaaleyAvevlkvkhivVlGHskCGavkaalkaekseeeagaidkwlekirealekve 99 
                 +++igCsDSRvpp+++t+++pG++F++rnv+nlv+++d + +++l+yAvevl+vkh++V+GH++CG+v aal++    ++ g id+wl++i+++++ ++
  EFC36108.1 175 YMLIGCSDSRVPPDQLTKTQPGQIFIHRNVANLVVNTDVNAMSVLQYAVEVLQVKHVIVMGHTRCGGVMAALTN----KHLGLIDHWLRNIKDVYRLHK 269
                 589******************************************************************99985....2379*************9988 PP

                 HHH CS
      Pro_CA 100 eel 102
                 +e 
  EFC36108.1 270 AEW 272
                 764 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   5.2   0.00013       1.2     264     360 ..       5     102 ..       1     202 [. 0.57

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00013
    Macoilin 264 ssrsdskkkhehn.esvdsklqekeyme.nkskskrlsksessgsesellveesvksksssss.sssnknskkasagsagssnssskkhsessksvtss 359
                 +++++++++hehn +    ++q++++++ n ++++ ls +es+ ++ + + +++  s+ s ++ ss+++  +   +++++ s+ s+++   ++ s+++ 
  EFC36108.1   5 ADQQQEQHHHEHNgQCCGGNHQQAQHLTvNDVSPNTLSGDESEFNSGSSHNTKKKVSGISIKKkSSTSSLGEAGCSHQIDYSQLSAANN--QNLSRPEP 101
                 23334444444445777788888887643777777777776665555554444444444433303333333333333444444343333..33333333 PP

    Macoilin 360 s 360
                 s
  EFC36108.1 102 S 102
                 2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1688.78
//
Query:       EFC36109.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1011  (0.0563891); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1038.72
//
Query:       EFC36110.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.031   14.4   0.1      0.051   13.7   0.1    1.3  1  DUF305    Domain of unknown function (DUF305)


Domain annotation for each model (and alignments):
>> DUF305  Domain of unknown function (DUF305)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   2.8e-06     0.051      94     143 ..      66     116 ..      58     125 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.8e-06
                 S-HHHHHHHHHHHHHHHHHHHHHHHGGGG-.----HHHHHHHHHHHHHHHH CS
      DUF305  94 asgadfdrlFlelMirhHqgavemaeaale.kgedpevrelaeaiieaQqa 143
                  s  +f  l+++ Mi+  + ++e+ae  l+ + +++e  +l++++ ++ ++
  EFC36110.1  66 HSNSNFTSLWINFMIASKREGIELAEFGLNsQNSNQEFLSLMQEMKNNATE 116
                 567899********************988757889999*******988665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       924  (0.0515366); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1441.97
//
Query:       EFC36111.1  [L=108]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00062   19.5   0.1       0.57    9.8   0.1    2.2  2  CoaE      Dephospho-CoA kinase


Domain annotation for each model (and alignments):
>> CoaE  Dephospho-CoA kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.1   3.2e-05      0.57       3      22 ..      11      29 ..       9      34 .. 0.86
   2 !    7.9   0.0   0.00013       2.2      25      72 ..      50     107 ..      39     108 .] 0.79

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 3.2e-05
                EEEEESTTSSHHHHHHHHHH CS
        CoaE  3 vgltGgiasGKstvanlfad 22
                vgltG i sGKstv +++ +
  EFC36111.1 11 VGLTG-ICSGKSTVVSYLGE 29
                89996.*********99876 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00013
                 -EEEEHHHHHHHTTCCTHHHHHHHHHHHG..........GGCB.TTSSE-HHHHHHHH CS
        CoaE  25 vpivDaDlvArqvvepgsealkkiveeFg..........eeildedGeLdReaLrkkv 72 
                 ++++ +D +  ++   g+e +k++ve F           +++lde+ +++R++L++ +
  EFC36111.1  50 FHVIPTDELGWKAYSVGTECYKQVVEVFTplvkqivgeeASLLDEQQQINRRMLGNYI 107
                 5678888888888888888888888888877766666667889999999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       436  (0.0243181); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.52
# Mc/sec: 627.55
//
Query:       EFC36112.1  [L=123]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.6e-06   25.9  73.4     0.0034   17.4  35.8    2.2  2  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5  37.1   1.4e-06     0.026      59     111 ..       3      55 ..       1      56 [. 0.46
   2 !   17.4  35.8   1.9e-07    0.0034      59     115 ..      47     103 ..      46     111 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.4e-06
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC36112.1   3 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 55 
                  34444444444444444444444555555555555555555555555555554 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 1.9e-07
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepepgaat 115
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p + t
   EFC36112.1  47 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKTQT 103
                  566677777777777777777777777777777777777777777777777776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       840  (0.0468515); expected 358.6 (0.02)
Passed bias filter:                      223  (0.0124379); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                        38  (0.00211947); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.81u 0.35s 00:00:01.16 Elapsed: 00:00:00.51
# Mc/sec: 724.13
//
Query:       EFC36113.1  [L=479]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-49  164.4  12.9    6.7e-10   39.3   0.6    6.2  6  Sel1      Sel1 repeat
    0.00029   20.7  14.5        6.8    7.1   0.0    6.2  7  TPR_2     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.026   14.8   0.7         83    3.6   0.1    4.3  4  TPR_12    Tetratricopeptide repeat
      0.096   12.4   8.8         26    4.6   0.1    5.0  4  TPR_11    TPR repeat
        0.2   12.4   0.6         25    5.6   0.0    3.1  3  TPR_16    Tetratricopeptide repeat
        0.3   11.0  18.2         31    4.6   0.1    6.4  7  TPR_1     Tetratricopeptide repeat
       0.63   10.8   4.6         19    6.2   0.0    4.3  5  TPR_6     Tetratricopeptide repeat
          5    7.6  21.4         15    6.1   0.0    6.8  9  TPR_8     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   3.2e-06    0.0071      20      37 ..      61      78 ..      51      79 .. 0.92
   2 !   39.3   0.6     3e-13   6.7e-10       1      37 [.      80     114 ..      80     115 .. 0.94
   3 !   31.1   0.1   1.1e-10   2.5e-07       7      38 .]     122     151 ..     120     151 .. 0.94
   4 !   33.6   0.3   1.9e-11   4.2e-08       1      37 [.     152     186 ..     152     187 .. 0.92
   5 !   39.2   0.1   3.2e-13   7.3e-10       1      38 []     188     223 ..     188     223 .. 0.92
   6 !    7.8   0.0    0.0024       5.4       2      24 ..     225     245 ..     224     247 .. 0.89

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3.2e-06
        Sel1 20 pkDpekAiewyekAAeqG 37
                +kD+ kA+ew+ k AeqG
  EFC36113.1 61 EKDYGKAFEWFTKGAEQG 78
                79***************9 PP

  == domain 2  score: 39.3 bits;  conditional E-value: 3e-13
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 ae+ y+ G  y+y nGl v++D++kA+ewy kAAe+G
  EFC36113.1  80 AESTYKIG--YFYANGLEVDTDYSKAMEWYLKAAEMG 114
                 6899****..777***********************9 PP

  == domain 3  score: 31.1 bits;  conditional E-value: 1.1e-10
        Sel1   7 LGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  G  yly++G+gv++D+ +A++w+ kA e+G+
  EFC36113.1 122 IG--YLYFFGKGVEQDYVEALKWFLKAVEKGS 151
                 69..999**********************996 PP

  == domain 4  score: 33.6 bits;  conditional E-value: 1.9e-11
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 aeA+  +G   ly +G+gv++D +kA+ewy kAAe+G
  EFC36113.1 152 AEAYVSMG--NLYSKGTGVERDLSKAMEWYLKAAENG 186
                 6899999*..677**********************99 PP

  == domain 5  score: 39.2 bits;  conditional E-value: 3.2e-13
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 + A+++ G    y++G gv+++++kA+ewy kAAe+G+
  EFC36113.1 188 STAQFNIG--RSYYFGFGVERNYSKAVEWYLKAAENGN 223
                 57******..666***********************97 PP

  == domain 6  score: 7.8 bits;  conditional E-value: 0.0024
        Sel1   2 eAmyrLGmfylylnGlgvpkDpe 24 
                 +A++++G   l+++G+g++k+ +
  EFC36113.1 225 SAQFKVG--FLFETGKGIEKNFK 245
                 7******..999********965 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.0     0.008        18       4      28 ..      51      75 ..      49      77 .. 0.89
   2 ?    5.3   0.1     0.011        26       9      29 ..      92     112 ..      88     114 .. 0.80
   3 !    7.1   0.0     0.003       6.8      15      29 ..     134     148 ..     132     150 .. 0.91
   4 ?   -2.5   0.0       3.5   7.9e+03       1      11 [.     152     162 ..     152     164 .. 0.79
   5 ?    1.7   0.1      0.16   3.6e+02      16      29 ..     171     184 ..     169     185 .. 0.87
   6 ?   -1.1   0.0       1.3   2.8e+03       3      12 ..     190     199 ..     188     200 .. 0.88
   7 !    5.5   0.1    0.0095        21      15      29 ..     206     220 ..     204     223 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.008
       TPR_2  4 lynlGlayyklgdyeeAleafekAl 28
                ++ lG+ +   +dy +A e+f k  
  EFC36113.1 51 YHSLGCKCKDEKDYGKAFEWFTKGA 75
                7889*****************9975 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.011
       TPR_2   9 layyklgdyeeAleafekAle 29 
                 + ++   dy +A e++ kA e
  EFC36113.1  92 NGLEVDTDYSKAMEWYLKAAE 112
                 55666679***********87 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.003
       TPR_2  15 gdyeeAleafekAle 29 
                 +dy eAl++f kA+e
  EFC36113.1 134 QDYVEALKWFLKAVE 148
                 79***********98 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 3.5
       TPR_2   1 aealynlGlay 11 
                 aea+  +G++y
  EFC36113.1 152 AEAYVSMGNLY 162
                 78899999988 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.16
       TPR_2  16 dyeeAleafekAle 29 
                 d+ +A e++ kA e
  EFC36113.1 171 DLSKAMEWYLKAAE 184
                 789*********86 PP

  == domain 6  score: -1.1 bits;  conditional E-value: 1.3
       TPR_2   3 alynlGlayy 12 
                 a +n+G++yy
  EFC36113.1 190 AQFNIGRSYY 199
                 789******8 PP

  == domain 7  score: 5.5 bits;  conditional E-value: 0.0095
       TPR_2  15 gdyeeAleafekAle 29 
                  +y +A+e++ kA e
  EFC36113.1 206 RNYSKAVEWYLKAAE 220
                 69***********86 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.037        84      45      70 ..      48      73 ..      44      77 .. 0.89
   2 ?   -1.3   0.0       1.2   2.8e+03      60      73 ..      99     112 ..      91     113 .. 0.75
   3 ?    1.9   0.0      0.12   2.7e+02      17      31 ..     134     148 ..     132     165 .. 0.84
   4 ?    3.6   0.1     0.037        83      25      72 ..     171     219 ..     169     223 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.037
      TPR_12 45 attlrnLgrlyralgryeeAlellee 70
                 t+++ Lg  +   ++y +A e++++
  EFC36113.1 48 GTSYHSLGCKCKDEKDYGKAFEWFTK 73
                589********999*********997 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.2
      TPR_12  60 ryeeAlelleeala 73 
                 +y +A e++ +a +
  EFC36113.1  99 DYSKAMEWYLKAAE 112
                 67777777777766 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.12
      TPR_12  17 grydeAlellekale 31 
                 ++y eAl+++ ka+e
  EFC36113.1 134 QDYVEALKWFLKAVE 148
                 688899999998876 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.037
      TPR_12  25 llekaleiarrllGpdhpltattlrnLgrlyr.alg...ryeeAlelleeal 72 
                  l ka+e + ++   ++ + +t+++n+gr y+  +g   +y +A+e++ +a 
  EFC36113.1 171 DLSKAMEWYLKA--AEN-GCSTAQFNIGRSYYfGFGverNYSKAVEWYLKAA 219
                 678899999666..555.6899999999997535555557777777777775 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1     0.028        63       9      22 ..      99     112 ..      99     113 .. 0.89
   2 ?    4.6   0.1     0.012        26       9      39 ..     135     163 ..     133     165 .. 0.81
   3 ?    1.4   0.1      0.11   2.6e+02      10      21 ..     172     183 ..     171     184 .. 0.86
   4 ?    4.2   0.3     0.016        35       9      21 ..     207     219 ..     207     227 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.028
      TPR_11   9 kyeeAieaYkkAlk 22 
                 +y +A+e+Y kA +
  EFC36113.1  99 DYSKAMEWYLKAAE 112
                 699*********65 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.012
      TPR_11   9 kyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 +y eA++++ kA++    +aeay  +G++y 
  EFC36113.1 135 DYVEALKWFLKAVE--KGSAEAYVSMGNLYS 163
                 78899999999997..467999999999996 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.11
      TPR_11  10 yeeAieaYkkAl 21 
                 + +A+e+Y kA 
  EFC36113.1 172 LSKAMEWYLKAA 183
                 789*******96 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.016
      TPR_11   9 kyeeAieaYkkAl 21 
                 +y +A+e+Y kA 
  EFC36113.1 207 NYSKAVEWYLKAA 219
                 699********96 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.54   1.2e+03      32      62 ..      78     112 ..      63     114 .. 0.67
   2 ?    5.6   0.0     0.011        25      12      63 ..     135     185 ..     131     190 .. 0.76
   3 ?    4.7   0.1     0.022        49      19      65 ..     175     223 ..     170     226 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.54
      TPR_16  32 daaeAllllgdaalrq....grlaeAaalyraalr 62 
                  +ae+ +  g  ++       ++ +A ++y++a++
  EFC36113.1  78 GCAESTYKIGYFYANGlevdTDYSKAMEWYLKAAE 112
                 46666666666666665666799999999999876 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.011
      TPR_16  12 dyddAaaaleaalkrdpssPdaaeAllllgdaalrq....grlaeAaalyraalra 63 
                 dy +A++ +  a++++      aeA+   g+++ +      +l +A ++y++a+++
  EFC36113.1 135 DYVEALKWFLKAVEKG-----SAEAYVSMGNLYSKGtgveRDLSKAMEWYLKAAEN 185
                 4455555555555555.....88999999999999999999999999999999865 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.022
      TPR_16  19 aleaalkrdpssPdaaeAllllgdaal.rq...grlaeAaalyraalraap 65 
                 a e++lk++     +  A+++ g++++  +    ++ +A+++y++a++++ 
  EFC36113.1 175 AMEWYLKAAENG--CSTAQFNIGRSYYfGFgveRNYSKAVEWYLKAAENGN 223
                 567777777433..88999999999995558889************98876 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.014        31       4      27 ..      51      74 ..      49      77 .. 0.89
   2 ?    2.9   0.1     0.048   1.1e+02      16      29 ..      99     112 ..      99     113 .. 0.90
   3 ?    4.4   0.1     0.016        36      15      29 ..     134     148 ..     132     149 .. 0.91
   4 ?    2.2   0.0     0.082   1.8e+02       1      13 [.     152     164 ..     152     165 .. 0.91
   5 ?    0.6   0.1      0.25   5.6e+02      16      29 ..     171     184 ..     169     185 .. 0.85
   6 ?   -3.8   0.1       6.2   1.4e+04       3      12 ..     190     199 ..     190     199 .. 0.81
   7 ?    4.2   0.1     0.018        41      16      29 ..     207     220 ..     204     221 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.014
                HHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1  4 lynlGnayfklgkydeAleyyekA 27
                +  lG  +   ++y +A e + k 
  EFC36113.1 51 YHSLGCKCKDEKDYGKAFEWFTKG 74
                8899*****************985 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.048
                 -HHHHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekALe 29 
                 +y +A e y kA e
  EFC36113.1  99 DYSKAMEWYLKAAE 112
                 79*********976 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.016
                 T-HHHHHHHHHHHHH CS
       TPR_1  15 gkydeAleyyekALe 29 
                 ++y eAl+ + kA+e
  EFC36113.1 134 QDYVEALKWFLKAVE 148
                 69***********97 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.082
                 HHHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayfk 13 
                 a+a+  +Gn+y k
  EFC36113.1 152 AEAYVSMGNLYSK 164
                 89*********86 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.25
                 -HHHHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekALe 29 
                 ++ +A e y kA e
  EFC36113.1 171 DLSKAMEWYLKAAE 184
                 789********965 PP

  == domain 6  score: -3.8 bits;  conditional E-value: 6.2
                 HHHHHHHHHH CS
       TPR_1   3 alynlGnayf 12 
                 a +n+G  y+
  EFC36113.1 190 AQFNIGRSYY 199
                 5689999997 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.018
                 -HHHHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekALe 29 
                 +y +A+e y kA e
  EFC36113.1 207 NYSKAVEWYLKAAE 220
                 9**********965 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1      0.11   2.6e+02       4      21 ..      84     105 ..      81     111 .. 0.84
   2 ?   -2.2   0.0       3.8   8.6e+03       5      22 ..     121     139 ..     120     145 .. 0.63
   3 ?   -1.4   0.1       2.2     5e+03       1      21 [.     153     177 ..     153     183 .. 0.72
   4 ?    6.2   0.0    0.0084        19       2      21 ..     190     213 ..     189     220 .. 0.86
   5 ?   -0.7   0.0       1.3   2.8e+03      21      33 .]     461     474 ..     459     474 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.11
                 HHHHHHHHHH....HHHHHHHH CS
       TPR_6   4 yklalsyrkl....gdtdkAle 21 
                 yk+++ y ++    +d++kA+e
  EFC36113.1  84 YKIGYFYANGlevdTDYSKAME 105
                 9********66**99*****98 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 3.8
                 HHHHHHHHH.HHHHHHHHH CS
       TPR_6   5 klalsyrkl.gdtdkAlea 22 
                 +++++y+ + g  ++ +ea
  EFC36113.1 121 QIGYLYFFGkGVEQDYVEA 139
                 6899999853344444444 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 2.2
                 HHHHHHHHHHHHH....HHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtdkAle 21 
                 +A+  ++ +y k+     d +kA+e
  EFC36113.1 153 EAYVSMGNLYSKGtgveRDLSKAME 177
                 5788899999996566667777776 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0084
                 HHHHHHHHHHHH....HHHHHHHH CS
       TPR_6   2 Alyklalsyrkl....gdtdkAle 21 
                 A++++++sy+ +     +++kA+e
  EFC36113.1 190 AQFNIGRSYYFGfgveRNYSKAVE 213
                 99********99999999999998 PP

  == domain 5  score: -0.7 bits;  conditional E-value: 1.3
                 HHHHHHHHH.-TT- CS
       TPR_6  21 ealerlike.YPdS 33 
                 ++l+ l+++ +P+S
  EFC36113.1 461 KILDVLVNNkFPNS 474
                 6888899998***8 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0    0.0066        15       3      27 ..      50      74 ..      48      76 .. 0.91
   2 ?   -3.4   0.1       7.7   1.7e+04       2      12 ..      81      91 ..      80      92 .. 0.74
   3 ?    4.3   0.2     0.025        55      16      30 ..      99     113 ..      98     113 .. 0.91
   4 ?   -3.3   0.0         7   1.6e+04       6      12 ..     121     127 ..     120     131 .. 0.79
   5 ?    0.1   0.0      0.57   1.3e+03      16      29 ..     135     148 ..     133     148 .. 0.84
   6 ?    3.6   0.5     0.041        92       1      28 [.     152     183 ..     152     185 .. 0.67
   7 ?   -3.0   0.0       5.4   1.2e+04       3      11 ..     190     198 ..     189     203 .. 0.79
   8 ?    3.0   0.1     0.067   1.5e+02      16      29 ..     207     220 ..     205     221 .. 0.88
   9 ?   -3.3   0.0       6.8   1.5e+04       3      16 ..     426     439 ..     425     440 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0066
                HHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8  3 ayynlgsiylklgdyeeAkeyyeka 27
                +y+ lg+ +++ +dy +A e++ k 
  EFC36113.1 50 SYHSLGCKCKDEKDYGKAFEWFTKG 74
                799*******************985 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 7.7
                CHHHHHHHHHH CS
       TPR_8  2 eayynlgsiyl 12
                e+ y++g+ y 
  EFC36113.1 81 ESTYKIGYFYA 91
                55689999996 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.025
                 -HHHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekalel 30 
                 dy +A+e+y ka e+
  EFC36113.1  99 DYSKAMEWYLKAAEM 113
                 899*********885 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 7
                 HHHHHHH CS
       TPR_8   6 nlgsiyl 12 
                 ++g++y+
  EFC36113.1 121 QIGYLYF 127
                 79***96 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.57
                 -HHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekale 29 
                 dy eA +++ ka+e
  EFC36113.1 135 DYVEALKWFLKAVE 148
                 67799*******97 PP

  == domain 6  score: 3.6 bits;  conditional E-value: 0.041
                 CCHHHHHHHHHHH....TT-HHHHHHHHHHHH CS
       TPR_8   1 aeayynlgsiylk....lgdyeeAkeyyekal 28 
                 aeay+ +g++y+k      d+ +A+e+y ka 
  EFC36113.1 152 AEAYVSMGNLYSKgtgvERDLSKAMEWYLKAA 183
                 56777777777443333358889999999986 PP

  == domain 7  score: -3.0 bits;  conditional E-value: 5.4
                 HHHHHHHHH CS
       TPR_8   3 ayynlgsiy 11 
                 a +n+g+ y
  EFC36113.1 190 AQFNIGRSY 198
                 679999888 PP

  == domain 8  score: 3.0 bits;  conditional E-value: 0.067
                 -HHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekale 29 
                 +y +A+e+y ka e
  EFC36113.1 207 NYSKAVEWYLKAAE 220
                 899********975 PP

  == domain 9  score: -3.3 bits;  conditional E-value: 6.8
                 HHHHHHHHHHHTT- CS
       TPR_8   3 ayynlgsiylklgd 16 
                 +++ +g++  +++d
  EFC36113.1 426 SCFVMGDLFTTMND 439
                 68999**9999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (479 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 3062.81
//
Query:       EFC36114.1  [L=395]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-14   53.3   0.2    2.9e-13   50.0   0.0    2.4  2  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.0   0.0   1.6e-17   2.9e-13       2      90 ..       9     100 ..       8     110 .. 0.92
   2 ?    0.5   0.0      0.04   7.2e+02      42      74 ..     162     192 ..     124     211 .. 0.76

  Alignments for each domain:
  == domain 1  score: 50.0 bits;  conditional E-value: 1.6e-17
                 EEEEEEEEEESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEEEEEEEEESC.HTTSEEEEEEEEECSSSTEEEEEEEEEEGHH CS
          C2   2 klevtvieAknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWnekftfevae.leeakLeveVfdndrlskddfiGkveiplst 90 
                 +l+++++++ nLp+ d  + +d+y+++++     + +k+kT+ i+n+ nP+W  kf f +++ ++++ + veV+d+d++skdd++ ++ +p + 
  EFC36114.1   9 TLSLKIHSGFNLPKTDLLSGIDAYCVIHVpllgGKIEKFKTKSIDNNPNPEW--KFAFFITNvDSSKDIFVEVWDKDTFSKDDLVCRAYLPSAL 100
                 699**************999************99********999999****..88888888889********************999998765 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.04
                 SSSSSSEEEEEEEEEESCHTTSEEEEEEEEECS CS
          C2  42 knslnPvWnekftfevaeleeakLeveVfdndr 74 
                   +l  ++n +++++v+   ++k  +++fd ++
  EFC36114.1 162 VHQLTGIFNDSLYLKVSV--NKKFNISIFDTSK 192
                 666788999999999998..9999999999655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (395 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      311  (0.0173462); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.25s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 2566.74
//
Query:       EFC36115.1  [L=159]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-21   74.4   8.6    0.00018   21.3   0.1    6.3  6  LRR_6     Leucine Rich repeat
      9e-14   51.0   4.4    0.00016   21.4   0.4    3.4  3  LRR_8     Leucine rich repeat
    1.5e-11   44.4  13.9      0.014   15.8   0.0    4.7  5  LRR_4     Leucine Rich repeats (2 copies)
    7.7e-05   22.7  11.3          4    8.4   0.2    6.0  6  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
      0.032   14.5   0.3          1    9.7   0.0    3.2  4  Toxin_30  Ptu family


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.0   8.3e-05       0.3       5      23 ..      18      37 ..      15      38 .. 0.92
   2 !    5.0   0.1    0.0087        31       4      16 ..      42      54 ..      39      55 .. 0.85
   3 !   21.3   0.1   5.1e-08   0.00018       5      23 ..      68      86 ..      67      87 .. 0.95
   4 !   13.6   0.0   1.5e-05     0.052       7      23 ..      94     110 ..      90     111 .. 0.87
   5 !   17.2   0.0   1.1e-06    0.0038       5      24 .]     116     135 ..     113     135 .. 0.91
   6 !    6.0   0.0    0.0039        14       5      24 .]     140     159 .]     137     159 .] 0.89

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 8.3e-05
       LRR_6  5 LteLdLsgNd.IgDeGaeaL 23
                L++L+L +N+ I+  G++ L
  EFC36115.1 18 LKKLNLEYNNnIDPNGIKYL 37
                9***************9987 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0087
       LRR_6  4 hLteLdLsgNdIg 16
                 Lt L++s++ Ig
  EFC36115.1 42 QLTDLNISCCYIG 54
                59********776 PP

  == domain 3  score: 21.3 bits;  conditional E-value: 5.1e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+Ld+++N+I+ eGa+++
  EFC36115.1 68 LTHLDIASNNISAEGAKCI 86
                9****************98 PP

  == domain 4  score: 13.6 bits;  conditional E-value: 1.5e-05
       LRR_6   7 eLdLsgNdIgDeGaeaL 23 
                  L++ +NdIg eGa+ +
  EFC36115.1  94 NLSIGSNDIGTEGAKYI 110
                 699***********977 PP

  == domain 5  score: 17.2 bits;  conditional E-value: 1.1e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ L+++ N+Ig eGa+ ++
  EFC36115.1 116 LKQLHIANNNIGPEGAKYIS 135
                 99**************9885 PP

  == domain 6  score: 6.0 bits;  conditional E-value: 0.0039
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+  NdI+  Ga++++
  EFC36115.1 140 LTYLDICLNDINEYGAKCIS 159
                 9**********999999885 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   1.1   1.5e-05     0.055      22      54 ..      13      43 ..       7      49 .. 0.88
   2 !   21.4   0.4   4.4e-08   0.00016       2      61 .]      42     102 ..      41     102 .. 0.94
   3 !   18.3   0.0     4e-07    0.0014       2      44 ..     115     157 ..     109     159 .] 0.88

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.5e-05
                TT-TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8 22 kglsnLkvLdLsnNllttlspgafsgLpsLrsL 54
                 ++++Lk L+L +N  + ++p+ +  L sL++L
  EFC36115.1 13 DSMKGLKKLNLEYN--NNIDPNGIKYLGSLKQL 43
                6799**********..89999999999999988 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 4.4e-08
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L++s+ ++   +  +  + l++L++Ld+ +N+++   ++++  +++L  L + +N++
  EFC36115.1  42 QLTDLNISCCYIGLTENLSYLTlLKALTHLDIASNNISAEGAKCIGEMKQLANLSIGSNDI 102
                 79999999999999999998888************************************97 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 4e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGG CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspga 44 
                 +L+ L++ nN++   + +  +gl++L++Ld+  N ++   +++
  EFC36115.1 115 QLKQLHIANNNIGPEGAKYISGLEQLTYLDICLNDINEYGAKC 157
                 7999999999999999999999999999999999999876665 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.8   2.1e-05     0.075      13      38 ..       9      31 ..       4      36 .. 0.78
   2 !   14.3   3.7   1.1e-05      0.04       2      37 ..      17      54 ..      16      61 .. 0.80
   3 !   15.8   0.0     4e-06     0.014       2      39 ..      67     102 ..      66     105 .. 0.83
   4 !   13.1   0.2   2.8e-05       0.1       3      36 ..      92     126 ..      90     132 .. 0.78
   5 !   14.5   0.5     1e-05     0.036       1      40 [.     114     151 ..     114     155 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.1e-05
                --E-S-HHH-TT--EEE-.-S----- CS
       LRR_4 13 ltdiplleklpnLkeLdLsgNnlitd 38
                l+    l +++ Lk+L+L  Nn+i++
  EFC36115.1  9 LQV---LDSMKGLKKLNLEYNNNIDP 31
                444...445*********99999965 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1.1e-05
                S--EEE--.SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4  2 nLevLdLs.nNqltdipl..leklpnLkeLdLsgNnlit 37
                 L++L+L  nN++   +   l++l++L+ L++s + +i+
  EFC36115.1 17 GLKKLNLEyNNNIDPNGIkyLGSLKQLTDLNISCC-YIG 54
                7*******99**99666677889*********666.774 PP

  == domain 3  score: 15.8 bits;  conditional E-value: 4e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                  L++Ld+++N+++  +   ++ +++L  L++ +N    d+
  EFC36115.1  67 ALTHLDIASNNISAEGAkcIGEMKQLANLSIGSN----DI 102
                 7************777785445*********778....76 PP

  == domain 4  score: 13.1 bits;  conditional E-value: 2.8e-05
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 L +L++++N + + +   ++ +++Lk+L++  Nn+i
  EFC36115.1  92 LANLSIGSNDIGTEGAkyIGEMKQLKQLHI-ANNNI 126
                 667999999999888875446*********.55566 PP

  == domain 5  score: 14.5 bits;  conditional E-value: 1e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdld 40 
                 ++L+ L+++nN++   +   +++l +L++Ld+  +  ++d++
  EFC36115.1 114 KQLKQLHIANNNIGPEGAkyISGLEQLTYLDI--C--LNDIN 151
                 589***********544466668********8..3..33765 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       3.5   1.3e+04       1       6 [.       8      13 ..       8      13 .. 0.89
   2 !    8.4   0.2    0.0011         4       2      20 ..      18      34 ..      17      37 .. 0.78
   3 ?    3.2   0.3     0.054   1.9e+02       2      15 ..      43      55 ..      42      64 .. 0.80
   4 !    8.1   0.0    0.0014         5       2      20 ..      68      86 ..      67     111 .. 0.80
   5 ?    3.9   0.0     0.033   1.2e+02       1      17 [.     115     131 ..     115     137 .. 0.72
   6 ?    1.8   0.0      0.16   5.7e+02       1      12 [.     139     150 ..     139     159 .] 0.74

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.5
       LRR_1  1 nLrhLd 6 
                nL++Ld
  EFC36115.1  8 NLQVLD 13
                899998 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0011
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                L++L+L++n++  + pn +
  EFC36115.1 18 LKKLNLEYNNN--IDPNGI 34
                9*********7..466655 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.054
       LRR_1  2 LrhLdLsnnpllgl 15
                L+ L++s + + gl
  EFC36115.1 43 LTDLNISCCYI-GL 55
                889******98.44 PP

  == domain 4  score: 8.1 bits;  conditional E-value: 0.0014
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                L+hLd+ +n+++  ++ ++
  EFC36115.1 68 LTHLDIASNNISAEGAKCI 86
                99****9999865555555 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.033
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L+ L++ nn+++  ++
  EFC36115.1 115 QLKQLHIANNNIGPEGA 131
                 5999******9855555 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld++ n +
  EFC36115.1 139 QLTYLDICLNDI 150
                 599****88876 PP

>> Toxin_30  Ptu family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       1.1   3.9e+03       8      21 ..      32      45 ..      31      52 .. 0.53
   2 ?    9.7   0.0   0.00028         1       7      19 ..      80      92 ..      74      97 .. 0.85
   3 ?    0.4   0.0      0.23   8.3e+02       8      18 ..     105     115 ..      98     116 .. 0.85
   4 ?   -1.3   0.0      0.79   2.8e+03       9      13 ..     154     158 ..     149     159 .] 0.73

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.1
                TTS--TTTT--BSS CS
    Toxin_30  8 rGakClGedKqCCe 21
                 G k lG  Kq  +
  EFC36115.1 32 NGIKYLGSLKQLTD 45
                56667777666443 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00028
                -TTS--TTTT--B CS
    Toxin_30  7 arGakClGedKqC 19
                a GakC+Ge Kq 
  EFC36115.1 80 AEGAKCIGEMKQL 92
                78*********95 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.23
                 TTS--TTTT-- CS
    Toxin_30   8 rGakClGedKq 18 
                  Gak +Ge Kq
  EFC36115.1 105 EGAKYIGEMKQ 115
                 79******998 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.79
                 TS--T CS
    Toxin_30   9 GakCl 13 
                 GakC+
  EFC36115.1 154 GAKCI 158
                 77775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       363  (0.0202465); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.48
# Mc/sec: 995.53
//
Query:       EFC36116.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.3e-37  123.0  21.9     0.0032   17.4   0.0   12.1 13  LRR_6         Leucine Rich repeat
    2.7e-27   94.3  24.8    6.4e-07   29.0   0.2    5.9  7  LRR_8         Leucine rich repeat
    1.8e-20   72.7  23.8    0.00049   20.4   0.4    7.0  7  LRR_4         Leucine Rich repeats (2 copies)
    1.1e-05   25.3   0.9       0.61    9.9   0.0    4.2  3  DUF4347       Domain of unknown function (DUF4347)
    0.00029   20.4   7.5      0.037   13.5   1.0    3.3  3  LRR_9         Leucine-rich repeat
    0.00035   20.5   5.9        0.7    9.9   0.5    5.3  5  ApoB100_C     Apolipoprotein B100 C terminal
    0.00037   20.6   9.5    1.1e+02    4.0   0.0    8.8  9  LRR_1         Leucine Rich Repeat
     0.0038   17.2   0.7        2.9    7.9   0.0    3.6  3  Translat_reg  Bacteriophage translational regulator
  ------ inclusion threshold ------
      0.017   14.8   7.4        1.7    8.4   0.3    3.5  3  DUF4869       Domain of unknown function (DUF4869)
       0.24   11.9   0.1         45    4.6   0.0    3.7  4  DUF4089       Protein of unknown function (DUF4089)
        0.9    9.3   4.3          3    7.6   0.8    2.7  3  UPF0193       Uncharacterised protein family (UPF0193)
          3    7.7  18.4      0.032   14.1   4.6    2.7  2  Beta_helix    Right handed beta helix region


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   7.2e-06     0.011       5      24 .]       4      23 ..       2      23 .. 0.92
   2 !   10.9   0.0   0.00026      0.38       3      23 ..      26      46 ..      24      47 .. 0.87
   3 ?    0.7   0.0      0.49   7.4e+02       5      20 ..      52      67 ..      50      71 .. 0.78
   4 !   16.6   0.2   3.8e-06    0.0057       3      23 ..      74      94 ..      72      95 .. 0.90
   5 !   10.0   0.0   0.00051      0.76       5      23 ..     100     118 ..      98     119 .. 0.91
   6 !   16.0   0.0     6e-06    0.0089       3      23 ..     122     142 ..     120     143 .. 0.88
   7 !    6.5   0.0    0.0067        10       4      23 ..     147     166 ..     144     167 .. 0.88
   8 !    6.2   0.1    0.0084        13       4      24 .]     171     191 ..     168     191 .. 0.87
   9 !    9.7   0.0   0.00063      0.93       3      24 .]     193     214 ..     191     214 .. 0.92
  10 !   16.3   0.0   4.7e-06    0.0071       5      23 ..     219     237 ..     216     238 .. 0.91
  11 !   17.4   0.0   2.2e-06    0.0032       5      23 ..     243     261 ..     240     262 .. 0.92
  12 ?    0.4   0.0      0.62   9.3e+02       4      18 ..     266     280 ..     264     285 .. 0.78
  13 ?   -2.3   0.0       4.3   6.5e+03       5      10 ..     291     296 .]     289     296 .] 0.85

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 7.2e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt L++++NdI+ eGa+ ++
  EFC36116.1  4 LTNLNVRHNDIDEEGAKYIS 23
                9***************9875 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00026
       LRR_6  3 thLteLdLsgNdIgDeGaeaL 23
                +++ +Ld+sgN I+  Ga+ +
  EFC36116.1 26 MNVSTLDISGNSINKRGAKYI 46
                56789*************977 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.49
       LRR_6  5 LteLdLsgNdIgDeGa 20
                Lt L + ++ Ig eG 
  EFC36116.1 52 LTDLGMYCCSIGVEGT 67
                7888888999**9995 PP

  == domain 4  score: 16.6 bits;  conditional E-value: 3.8e-06
       LRR_6  3 thLteLdLsgNdIgDeGaeaL 23
                + Lt+L+++ N+IgDeGa+ +
  EFC36116.1 74 NQLTHLSININNIGDEGAKYI 94
                579***************977 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00051
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++ +N+Ig eG++ +
  EFC36116.1 100 LTDLSICDNKIGSEGVKYI 118
                 999*************977 PP

  == domain 6  score: 16.0 bits;  conditional E-value: 6e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +L +L +s+N+IgD Ga+ +
  EFC36116.1 122 KNLLKLYVSCNEIGDNGAQFI 142
                 58999*************977 PP

  == domain 7  score: 6.5 bits;  conditional E-value: 0.0067
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+Ld+s+ +I+  G++ +
  EFC36116.1 147 QLTKLDISSVNITPIGIKYI 166
                 69************999977 PP

  == domain 8  score: 6.2 bits;  conditional E-value: 0.0084
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 hL  L +s+N+I+  Ga+ ++
  EFC36116.1 171 HLIDLMISDNNIDSMGAKHIS 191
                 788899***********9985 PP

  == domain 9  score: 9.7 bits;  conditional E-value: 0.00063
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L++  N I+ eGa+ L+
  EFC36116.1 193 MKLTSLEVYNNTIDVEGAKYLS 214
                 79****************9885 PP

  == domain 10  score: 16.3 bits;  conditional E-value: 4.7e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++s N+IgD+G++ L
  EFC36116.1 219 LTNLEISKNEIGDKGVQFL 237
                 9***************987 PP

  == domain 11  score: 17.4 bits;  conditional E-value: 2.2e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld++ N+I+D+Ga+ +
  EFC36116.1 243 LTSLDINENKISDVGAKYI 261
                 9***************976 PP

  == domain 12  score: 0.4 bits;  conditional E-value: 0.62
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +L  L++ +N+I+ +
  EFC36116.1 266 NLIDLSVFDNEISED 280
                 577899*****9855 PP

  == domain 13  score: -2.3 bits;  conditional E-value: 4.3
       LRR_6   5 LteLdL 10 
                 Lt+Ld+
  EFC36116.1 291 LTYLDI 296
                 99**97 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.1   3.3e-06     0.005       2      55 ..       3      56 ..       2      62 .. 0.92
   2 ?    4.8   0.6     0.016        23       3      37 ..      52      86 ..      50      88 .. 0.77
   3 !   24.2   0.2   1.4e-08   2.1e-05       2      58 ..      99     155 ..      98     157 .. 0.97
   4 !   29.0   0.2   4.3e-10   6.4e-07       2      60 ..     147     204 ..     146     205 .. 0.96
   5 !   25.1   0.7   7.1e-09   1.1e-05       2      61 .]     194     253 ..     193     253 .. 0.97
   6 !   27.1   0.5   1.8e-09   2.7e-06       2      61 .]     218     277 ..     217     277 .. 0.96
   7 !   22.0   0.2   6.5e-08   9.8e-05       2      56 ..     242     296 .]     241     296 .] 0.95

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 3.3e-06
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55
                +Lt+L++++N + + + +  + l n+ +Ld+s N+++   ++ +  +++L+ L 
  EFC36116.1  3 QLTNLNVRHNDIDEEGAKYISELMNVSTLDISGNSINKRGAKYIGEMKQLTDLG 56
                79***********************************99999888888888886 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.016
                -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8  3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37
                Lt L   + ++ + + +  ++l++L++L+++ N++
  EFC36116.1 52 LTDLGMYCCSIGVEGTKYISSLNQLTHLSININNI 86
                66777777777777788888999999999999987 PP

  == domain 3  score: 24.2 bits;  conditional E-value: 1.4e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +Lt L++++N++ s + +   +l+nL  L+ s+N++    ++ +s +++L++Ld+s+
  EFC36116.1  99 QLTDLSICDNKIGSEGVKYIGQLKNLLKLYVSCNEIGDNGAQFISEMNQLTKLDISS 155
                 79****************************************************997 PP

  == domain 4  score: 29.0 bits;  conditional E-value: 4.3e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+Ld+s+ ++t ++ +  +++++L  L +s+N+++++ ++ +s++ +L+sL + +N 
  EFC36116.1 147 QLTKLDISSVNITPIGIKYISKMEHLIDLMISDNNIDSMGAKHISQM-KLTSLEVYNNT 204
                 7**********************************************.*****999886 PP

  == domain 5  score: 25.1 bits;  conditional E-value: 7.1e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL + nN + + + +  + +++L+ L++s N++     + +sg+++L+sLd++ N++
  EFC36116.1 194 KLTSLEVYNNTIDVEGAKYLSEMEQLTNLEISKNEIGDKGVQFLSGMKQLTSLDINENKI 253
                 69********************************************************97 PP

  == domain 6  score: 27.1 bits;  conditional E-value: 1.8e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L +s+N + + + ++ +g+++L++Ld+++N+++ + ++ +  +++L  L + +N +
  EFC36116.1 218 QLTNLEISKNEIGDKGVQFLSGMKQLTSLDINENKISDVGAKYILEMKNLIDLSVFDNEI 277
                 79************************************************9999999976 PP

  == domain 7  score: 22.0 bits;  conditional E-value: 6.5e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 +LtsLd++ N++++++ +    ++nL  L+  +N+++    + ++ +++L++Ld+
  EFC36116.1 242 QLTSLDINENKISDVGAKYILEMKNLIDLSVFDNEISEDIIERLREMKQLTYLDI 296
                 7*************************************6679***********95 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.4   5.6e-05     0.084       1      39 [.       2      38 ..       2      55 .. 0.88
   2 !   14.5   0.2   2.3e-05     0.035       2      37 ..      75     111 ..      74     121 .. 0.87
   3 !   16.6   0.3   5.2e-06    0.0078       1      39 [.     122     161 ..     122     168 .. 0.86
   4 !   10.0   0.1   0.00063      0.95       2      39 ..     171     207 ..     170     211 .. 0.83
   5 !   11.4   0.3   0.00023      0.35       2      36 ..     194     229 ..     194     231 .. 0.85
   6 !   20.4   0.4   3.3e-07   0.00049       2      39 ..     218     256 ..     217     260 .. 0.86
   7 !   10.9   0.1   0.00033       0.5       1      30 [.     265     296 .]     265     296 .] 0.92

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.6e-05
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39
                ++L++L+ ++N + + +   ++ l n  +Ld+sgN    ++
  EFC36116.1  2 KQLTNLNVRHNDIDEEGAkyISELMNVSTLDISGN----SI 38
                58************988886445************....55 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 2.3e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L++L+++ N++ d +   ++++++L+ L++ +N +i+
  EFC36116.1  75 QLTHLSININNIGDEGAkyIGQIKQLTDLSICDN-KIG 111
                 69******88****99987668********9788.665 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 5.2e-06
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdl 39 
                 +nL +L+ s N + d +  + + + +L++Ld+s+  +it++
  EFC36116.1 122 KNLLKLYVSCNEIGDNGAqFISeMNQLTKLDISSV-NITPI 161
                 69*******99****999*6655*********996.47777 PP

  == domain 4  score: 10.0 bits;  conditional E-value: 0.00063
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +L+ L +s+N++ + +   + +  +L++L +  Nn i d+
  EFC36116.1 171 HLIDLMISDNNIDSMGAkhI-SQMKLTSLEV-YNNTI-DV 207
                 6999**********999744.5999******.77777.55 PP

  == domain 5  score: 11.4 bits;  conditional E-value: 0.00023
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L   nN +   +   l+ + +L+ L +s N  i
  EFC36116.1 194 KLTSLEVYNNTIDVEGAkyLSEMEQLTNLEISKN-EI 229
                 79***********766688777*********999.55 PP

  == domain 6  score: 20.4 bits;  conditional E-value: 3.3e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +L++L +s N + d +   l+++++L++Ld+++N +i+d+
  EFC36116.1 218 QLTNLEISKNEIGDKGVqfLSGMKQLTSLDINEN-KISDV 256
                 79***********866687778*********888.88876 PP

  == domain 7  score: 10.9 bits;  conditional E-value: 0.00033
                 SS--EEE--SS---.E-S-.HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqlt.dipl.leklpnLkeLdL 30 
                 +nL+ L+ ++N ++ di   l+ +++L++Ld+
  EFC36116.1 265 KNLIDLSVFDNEISeDIIErLREMKQLTYLDI 296
                 69************888889889*******97 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.9   0.0   0.00041      0.61      85     121 ..      47      81 ..      23      86 .. 0.77
   2 !    8.2   0.0    0.0013         2      56     123 ..      87     155 ..      80     164 .. 0.64
   3 ?    2.9   0.0     0.058        87     103     122 ..     230     249 ..     185     261 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00041
     DUF4347  85 ealsedadillYgCnvAageaGeafvekLaqltgadv 121
                  ++++  d+ +Y C+++ +  G++++++L+qlt+ ++
  EFC36116.1  47 GEMKQLTDLGMYCCSIGVE--GTKYISSLNQLTHLSI 81 
                 45677889********987..************9987 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0013
     DUF4347  56 GsegalqLgnt.elnaenlekyaeelaqwgealsedadillYgCnvAageaGeafvekLaqltgadvaA 123
                 G+ega ++g+  +l++ ++ +++   + ++   + ++ + lY      g++G +f+++++qlt+ d+++
  EFC36116.1  87 GDEGAKYIGQIkQLTDLSICDNKIGSEGVKYIGQLKNLLKLYVSCNEIGDNGAQFISEMNQLTKLDISS 155
                 666666666654666666666543333332222233445677655566789***************975 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.058
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +f++ ++qlt  d+ 
  EFC36116.1 230 GDKGVQFLSGMKQLTSLDIN 249
                 57899999999999998885 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.0    0.0046       6.8      44     125 ..      28     110 ..       1     118 [. 0.66
   2 ?    3.0   0.3     0.043        64      63     125 ..     145     205 ..     119     213 .. 0.74
   3 !   13.5   1.0   2.5e-05     0.037      41     118 ..     216     294 ..     204     296 .] 0.83

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0046
       LRR_9  44 fdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnl...eelvltnnelqeladldPlaslkklellsllknpv 125
                   t+d+s n i+k  g  ++  +k l       + i+ +  +++ +l   ++l ++ n++ + +  + + ++k+l+ ls+ +n +
  EFC36116.1  28 VSTLDISGNSINKR-GAKYIGEMKQLTDLGMYCCSIGVEGTKYISSLnqlTHLSININNIGDEGA-KYIGQIKQLTDLSICDNKI 110
                 56889999999885.45566666666555555566655555555555000555555555555554.7788999999999999877 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.043
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 +++l  l +++  i+ i+ +    + +l  l++++n++++++     +s  kl++l + +n++
  EFC36116.1 145 MNQLTKLDISSVNITPIGIKYISKMEHLIDLMISDNNIDSMGA--KHISQMKLTSLEVYNNTI 205
                 6677777777778888888888888888889999999988887..344555677777777765 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 2.5e-05
       LRR_9  41 ldqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklell 118
                 ++q+  +++s n+i  + ++ +  +k+l +l +n+n+i  ++ +    + nl  l + +ne+ e   ++ l ++k+l++l
  EFC36116.1 216 MEQLTNLEISKNEIgdKGVQFLSGMKQLTSLDINENKISDVGAKYILEMKNLIDLSVFDNEISEDI-IERLREMKQLTYL 294
                 578889999999995445777888999999999*****9999999999999999999999988754.6899999999988 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.47   7.1e+02      19      30 ..      44      55 ..      36      58 .. 0.89
   2 ?    3.1   0.0      0.06        90      18      32 ..      91     105 ..      68     111 .. 0.88
   3 ?   -0.9   0.0       1.1   1.6e+03      13      33 ..     134     154 ..     120     158 .. 0.75
   4 ?    4.3   0.1     0.027        40      19      33 ..     164     178 ..     149     181 .. 0.89
   5 !    9.9   0.5   0.00047       0.7      11      50 ..     251     289 ..     244     296 .] 0.74

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.47
   ApoB100_C 19 kliaeskrLiDL 30
                k i e k+L DL
  EFC36116.1 44 KYIGEMKQLTDL 55
                889********9 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.06
   ApoB100_C  18 EkliaeskrLiDLsI 32 
                  k i + k+L DLsI
  EFC36116.1  91 AKYIGQIKQLTDLSI 105
                 58999*********9 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 1.1
   ApoB100_C  13 lsdyyEkliaeskrLiDLsIe 33 
                 + d   ++i+e ++L  L I 
  EFC36116.1 134 IGDNGAQFISEMNQLTKLDIS 154
                 555566899999999888775 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.027
   ApoB100_C  19 kliaeskrLiDLsIe 33 
                 k i++ + LiDL I 
  EFC36116.1 164 KYISKMEHLIDLMIS 178
                 789*********995 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00047
   ApoB100_C  11 dqlsdyyEkliaeskrLiDLsIekYhafLkYiteLLkkLq 50 
                 +++sd   k i e k LiDLs+     + ++i e L++++
  EFC36116.1 251 NKISDVGAKYILEMKNLIDLSVFDNE-ISEDIIERLREMK 289
                 68999999*************95533.4455555555555 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0      0.16   2.4e+02       2      20 ..       4      22 ..       3      25 .. 0.76
   2 ?    4.0   0.0     0.073   1.1e+02       4      13 ..      30      39 ..      27      63 .. 0.79
   3 ?    0.2   0.0       1.3   1.9e+03       2      15 ..      76      89 ..      75      96 .. 0.73
   4 ?   -0.5   0.0       2.2   3.3e+03       2      17 ..     100     115 ..      99     121 .. 0.73
   5 ?    0.6   0.0      0.97   1.4e+03       1      15 [.     123     137 ..     123     145 .. 0.74
   6 ?    1.2   0.1       0.6     9e+02       2      12 ..     148     158 ..     147     193 .. 0.60
   7 ?    0.4   0.0       1.1   1.6e+03       1      16 [.     194     209 ..     194     216 .. 0.76
   8 ?    1.2   0.0       0.6   8.9e+02       2      21 ..     219     238 ..     218     240 .. 0.79
   9 ?    3.7   0.0     0.091   1.4e+02       1      19 [.     242     260 ..     242     278 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.16
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                L+ L++++n ++  ++ ++
  EFC36116.1  4 LTNLNVRHNDIDEEGAKYI 22
                899******9976666655 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.073
       LRR_1  4 hLdLsnnpll 13
                +Ld+s+n++ 
  EFC36116.1 30 TLDISGNSIN 39
                8******984 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 1.3
       LRR_1  2 LrhLdLsnnpllgl 15
                L+hL ++ n++++ 
  EFC36116.1 76 LTHLSININNIGDE 89
                999*9987777655 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 2.2
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L+ L +++n +++ + 
  EFC36116.1 100 LTDLSICDNKIGSEGV 115
                 7889999999866555 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.97
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL +L++s n +++ 
  EFC36116.1 123 NLLKLYVSCNEIGDN 137
                 7889*****998554 PP

  == domain 6  score: 1.2 bits;  conditional E-value: 0.6
       LRR_1   2 LrhLdLsnnpl 12 
                 L++Ld+s+ ++
  EFC36116.1 148 LTKLDISSVNI 158
                 67777765444 PP

  == domain 7  score: 0.4 bits;  conditional E-value: 1.1
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L + nn ++  +
  EFC36116.1 194 KLTSLEVYNNTIDVEG 209
                 799****999876555 PP

  == domain 8  score: 1.2 bits;  conditional E-value: 0.6
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L +s n +++++ + ++
  EFC36116.1 219 LTNLEISKNEIGDKGVQFLS 238
                 889*******9888776665 PP

  == domain 9  score: 3.7 bits;  conditional E-value: 0.091
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++Ld++ n +++ ++ +
  EFC36116.1 242 QLTSLDINENKISDVGAKY 260
                 599*******997776655 PP

>> Translat_reg  Bacteriophage translational regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.052        78      31      79 ..      30      78 ..      24     117 .. 0.76
   2 !    7.9   0.0    0.0019       2.9      31      69 ..     126     164 ..     103     185 .. 0.79
   3 ?    2.2   0.1      0.12   1.7e+02      42     100 ..     256     284 ..     216     293 .. 0.51

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.052
                  EEEE-EEEEEETTEEEEEEHHHHHHHTT------HHHHHHHHHHHHHHH CS
  Translat_reg 31 vlyqschilqkkglyylvhfkellaldgrqveiteedivrrdsiaklle 79
                  +l  s   ++k+g  y+  +k+l  l   +  i  e  +   s+ +l  
    EFC36116.1 30 TLDISGNSINKRGAKYIGEMKQLTDLGMYCCSIGVEGTKYISSLNQLTH 78
                  5666777899***************999999999998887777776654 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0019
                   EEEE-EEEEEETTEEEEEEHHHHHHHTT------HHHHH CS
  Translat_reg  31 vlyqschilqkkglyylvhfkellaldgrqveiteediv 69 
                    ly sc  +  +g  ++  +++l +ld  +v+it   i+
    EFC36116.1 126 KLYVSCNEIGDNGAQFISEMNQLTKLDISSVNITPIGIK 164
                   489999999999999999999999999999999976554 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.12
                   TTEEEEEEHHHHHHHTT------HHHHHHHHHHHHHHHHTTS-EE-SS-EEE-S--SSS CS
  Translat_reg  42 kglyylvhfkellaldgrqveiteedivrrdsiaklledwnlikivpesreftkdltnk 100
                    g  y++                              e  nli++   ++e+ +d+ ++
    EFC36116.1 256 VGAKYIL------------------------------EMKNLIDLSVFDNEISEDIIER 284
                   2333444..............................4444444444444444444333 PP

>> DUF4869  Domain of unknown function (DUF4869)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.2    0.0044       6.6      56      96 ..      66     106 ..      55     112 .. 0.82
   2 ?    8.4   0.3    0.0011       1.7      54     100 ..     112     158 ..     104     172 .. 0.86
   3 ?    3.1   0.3     0.047        70      57     108 ..     210     260 ..     168     283 .. 0.65

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0044
     DUF4869  56 GvktLlllanedekifnvsacGdnCakwlleiakkkdltin 96 
                 G+k +  l++  +  +n+ ++Gd  ak++ +i + +dl i+
  EFC36116.1  66 GTKYISSLNQLTHLSININNIGDEGAKYIGQIKQLTDLSIC 106
                 66666666667778899***************999999986 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0011
     DUF4869  54 sgGvktLlllanedekifnvsacGdnCakwlleiakkkdltinlrhi 100
                 s Gvk +  l+n  + ++   ++Gdn a+++ e+ + ++l i+  +i
  EFC36116.1 112 SEGVKYIGQLKNLLKLYVSCNEIGDNGAQFISEMNQLTKLDISSVNI 158
                 789999999**************************999998876655 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.047
     DUF4869  57 vktLlllanedekifnvsacGdnCakwlleiakkkdltinlrhimdfgekkF 108
                 +k L  +++  +  +   ++Gd  +++l  + + + l in ++i d g k +
  EFC36116.1 210 AKYLSEMEQLTNLEISKNEIGDKGVQFLSGMKQLTSLDINENKISDVGAK-Y 260
                 55555555555555555556666666666666666666666666555522.2 PP

>> DUF4089  Protein of unknown function (DUF4089)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       5.3   7.9e+03       1      13 [.      93     105 ..      93     108 .. 0.87
   2 ?    4.6   0.0      0.03        45       1      19 [.     165     183 ..     165     188 .. 0.89
   3 ?    1.7   0.0      0.24   3.6e+02       1      15 [.     212     226 ..     212     229 .. 0.90
   4 ?   -0.2   0.0      0.97   1.5e+03       1      13 [.     260     272 ..     260     279 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 5.3
     DUF4089   1 YvdqtaallgLel 13 
                 Y+ q  +l +L++
  EFC36116.1  93 YIGQIKQLTDLSI 105
                 9999999*99999 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.03
     DUF4089   1 YvdqtaallgLeldpeyrp 19 
                 Y+  +++l++L +++  ++
  EFC36116.1 165 YISKMEHLIDLMISDNNID 183
                 99************98876 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.24
     DUF4089   1 YvdqtaallgLeldp 15 
                 Y+ ++++l +Le++ 
  EFC36116.1 212 YLSEMEQLTNLEISK 226
                 999**********85 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.97
     DUF4089   1 YvdqtaallgLel 13 
                 Y+ ++  l++L++
  EFC36116.1 260 YILEMKNLIDLSV 272
                 9**********97 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1       0.2     3e+02     185     208 ..     199     222 ..     186     230 .. 0.75
   2 ?    1.6   0.1      0.14   2.1e+02     172     205 ..     210     243 ..     198     255 .. 0.61
   3 ?    7.6   0.8     0.002         3     173     205 ..     259     291 ..     247     294 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.2
     UPF0193 185 kkYraiIeteIsqklrelealdkk 208
                 + Y+++I  e ++ l e+e+l + 
  EFC36116.1 199 EVYNNTIDVEGAKYLSEMEQLTNL 222
                 568888999999999999888765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.14
     UPF0193 172 keFLeeMeaLGqgkkYraiIeteIsqklreleal 205
                 +++L+eMe+L + +  +++I ++  q l  +++l
  EFC36116.1 210 AKYLSEMEQLTNLEISKNEIGDKGVQFLSGMKQL 243
                 5666666666666666666666555555555555 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.002
     UPF0193 173 eFLeeMeaLGqgkkYraiIeteIsqklreleal 205
                 +++ eM++L   + + ++I ++I ++lre+++l
  EFC36116.1 259 KYILEMKNLIDLSVFDNEISEDIIERLREMKQL 291
                 78899**************************98 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   8.8       8.3   1.2e+04      58     114 ..       8      42 ..       1     147 [. 0.48
   2 ?   14.1   4.6   2.2e-05     0.032      24     135 ..     161     278 ..     129     281 .. 0.76

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 8.3
                 EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-TT-S--EEES-EEESTT CS
  Beta_helix  58 tisnntisdnn.gggialfgasnnlienneitdnggsGiylnyssnntienNiidnna 114
                 ++++n i + +  +   l++ s   i++n i+++                       +
  EFC36116.1   8 NVRHNDIDEEGaKYISELMNVSTLDISGNSINKR-----------------------G 42 
                 3333333333322333333344444444444433.......................2 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 2.2e-05
                 -SEEE-SSS-.....EEES-EEES-SS-SEEE-TT-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-TT....-S--EEES-EEEST CS
  Beta_helix  24 yGiylrgssn....vvienneiannsgsGiyilgssnntisnntisdnn.gggialfgasnnlienneitdnggsGiylny....ssnntienNiidnn 113
                  Gi+  + +       i++n+i + +   i+  + +   ++nnti   +  +   +++  n  i++nei d    G+++ +     ++++i++N i+++
  EFC36116.1 161 IGIKYISKMEhlidLMISDNNIDSMGAKHISQMKLTSLEVYNNTIDVEGaKYLSEMEQLTNLEISKNEIGDK---GVQFLSgmkqLTSLDINENKISDV 256
                 46666666666666678889999999999999999**********655545888888999999999999999...6666654555777*********** PP

                 T--SEE---TT---EEES-EEE CS
  Beta_helix 114 agsGividdsssnvtvtnNtit 135
                 ++  i  + +  ++ v++N i+
  EFC36116.1 257 GAKYILEMKNLIDLSVFDNEIS 278
                 *888877777778888999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       589  (0.0328518); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 1760.42
//
Query:       EFC36117.1  [L=2962]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   2.5e-102  334.8 702.7    0.00035   20.9   9.0   45.8 45  EGF_2     EGF-like domain
  ------ inclusion threshold ------
      0.054   13.8   0.4          6    7.2   0.0    4.3  3  ArgoMid   Mid domain of argonaute


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   8.1   1.1e-07   0.00094       6      32 .]      61      86 ..      57      86 .. 0.92
   2 !   18.2   6.2   2.8e-07    0.0025       5      32 .]     100     126 ..      95     126 .. 0.90
   3 !   13.5   9.1     8e-06     0.071       6      32 .]     151     176 ..     146     176 .. 0.91
   4 !   15.5   7.0   1.9e-06     0.017       5      32 .]     419     445 ..     415     445 .. 0.87
   5 !    8.8   9.4   0.00023         2       7      32 .]     460     484 ..     456     484 .. 0.90
   6 !    4.9   9.0     0.004        36       5      32 .]     497     525 ..     489     525 .. 0.82
   7 !    7.4   8.6   0.00064       5.8       6      32 .]     535     561 ..     530     561 .. 0.86
   8 !   19.0   6.8   1.5e-07    0.0013       5      32 .]     574     601 ..     570     601 .. 0.85
   9 !   20.9   9.0   3.9e-08   0.00035       5      32 .]     614     640 ..     609     640 .. 0.90
  10 !    9.7   7.1   0.00012       1.1       6      32 .]     655     680 ..     650     680 .. 0.82
  11 !    9.1   5.3   0.00018       1.6       4      32 .]     692     719 ..     689     719 .. 0.85
  12 !   11.7   9.3   2.8e-05      0.25       5      32 .]     732     758 ..     724     758 .. 0.90
  13 !   15.9   6.3   1.4e-06     0.012       5      32 .]     771     797 ..     767     797 .. 0.90
  14 !    9.2   9.3   0.00018       1.6       5      32 .]     810     836 ..     802     836 .. 0.89
  15 !   18.9   2.9   1.6e-07    0.0014       7      32 .]     851     875 ..     847     875 .. 0.95
  16 !   19.7   5.1   8.9e-08    0.0008       4      32 .]     886     914 ..     884     914 .. 0.91
  17 !   13.6   9.3   7.6e-06     0.068       3      32 .]    1154    1182 ..    1152    1182 .. 0.92
  18 !   14.5   6.7   3.8e-06     0.034       6      32 .]    1196    1221 ..    1192    1221 .. 0.90
  19 !    7.7   7.9    0.0005       4.5       7      32 .]    1236    1262 ..    1231    1262 .. 0.79
  20 !   19.9   5.8   8.1e-08   0.00073       6      32 .]    1276    1301 ..    1272    1301 .. 0.92
  21 !   16.4  10.3   9.6e-07    0.0086       5      32 .]    1314    1340 ..    1309    1340 .. 0.86
  22 !   18.1   8.9   2.8e-07    0.0025       5      32 .]    1353    1379 ..    1350    1379 .. 0.87
  23 !   14.6   5.8   3.5e-06     0.031       5      32 .]    1392    1418 ..    1389    1418 .. 0.91
  24 !   16.8   6.7   7.5e-07    0.0068       6      32 .]    1432    1459 ..    1427    1459 .. 0.88
  25 !   11.3   5.5   3.9e-05      0.35       8      32 .]    1475    1500 ..    1469    1500 .. 0.83
  26 !   17.8   5.3   3.7e-07    0.0033       7      32 .]    1515    1539 ..    1509    1539 .. 0.94
  27 !   16.9  11.3   6.8e-07    0.0061       5      32 .]    1552    1578 ..    1546    1578 .. 0.90
  28 !    9.1   6.7   0.00018       1.6       5      32 .]    1591    1618 ..    1587    1618 .. 0.88
  29 !   13.4   7.9   8.4e-06     0.075       6      32 .]    1633    1658 ..    1628    1658 .. 0.87
  30 !   10.4   8.9   7.3e-05      0.66       4      32 .]    1913    1940 ..    1906    1940 .. 0.86
  31 !   16.8   7.0   7.2e-07    0.0065       6      32 .]    1954    1979 ..    1949    1979 .. 0.87
  32 !    9.8   5.2   0.00011      0.98       6      32 .]    1993    2020 ..    1989    2020 .. 0.88
  33 !   13.2   6.6   9.8e-06     0.088       5      32 .]    2033    2059 ..    2029    2059 .. 0.88
  34 !    9.9   6.3   0.00011      0.95       6      32 .]    2073    2098 ..    2068    2098 .. 0.86
  35 !   18.7  11.0   1.9e-07    0.0017       6      32 .]    2112    2137 ..    2107    2137 .. 0.85
  36 !   15.3   8.4   2.1e-06     0.019       4      32 .]    2149    2176 ..    2146    2176 .. 0.87
  37 !    8.4  10.0   0.00031       2.8       4      32 .]    2188    2215 ..    2181    2215 .. 0.84
  38 !   10.9  10.9   5.2e-05      0.47       6      32 .]    2229    2254 ..    2224    2254 .. 0.88
  39 !   13.4  12.0   8.7e-06     0.078       5      32 .]    2267    2293 ..    2259    2293 .. 0.87
  40 !   15.5  10.4   1.9e-06     0.017       4      32 .]    2505    2533 ..    2499    2533 .. 0.89
  41 !   10.9  10.8   5.2e-05      0.46       5      32 .]    2546    2572 ..    2542    2572 .. 0.90
  42 !    9.3   5.5   0.00017       1.5       6      32 .]    2586    2613 ..    2581    2613 .. 0.79
  43 !   12.5  10.1   1.6e-05      0.15       7      32 .]    2624    2650 ..    2618    2650 .. 0.90
  44 !   16.4   8.4   9.7e-07    0.0087       4      32 .]    2662    2690 ..    2660    2690 .. 0.86
  45 !   13.0   4.0   1.2e-05       0.1       4      23 ..    2938    2957 ..    2936    2960 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.1e-07
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                + C+g+GtC++   +C+C+sg+ G++C
  EFC36117.1 61 NVCSGNGTCIADD-ECQCNSGFLGNNC 86
                57*******9777.9************ PP

  == domain 2  score: 18.2 bits;  conditional E-value: 2.8e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ghG+C+ +  +C Cd +yqG +C
  EFC36117.1 100 QQVCNGHGICIGPD-VCLCDYNYQGESC 126
                 578********888.9***********9 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 8e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G+C +q   C+C++g+ G  C
  EFC36117.1 151 NVCSGRGSCSQQD-LCSCSAGFNGHRC 176
                 68********888.9*********999 PP

  == domain 4  score: 15.5 bits;  conditional E-value: 1.9e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G Cv+ +  C C+   +G+ C
  EFC36117.1 419 NSSCNGRGLCVANN-TCLCNEESYGDEC 445
                 789*******9555.9************ PP

  == domain 5  score: 8.8 bits;  conditional E-value: 0.00023
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C ghG C+++   C+C ++y G  C
  EFC36117.1 460 VCTGHGDCIATD-TCSCRDNYNGTWC 484
                 6*******9677.9*********988 PP

  == domain 6  score: 4.9 bits;  conditional E-value: 0.004
       EGF_2   5 deiCgghGtCvnqcGqCdC..dsgyqGktC 32 
                 +e C+ +G C +    C+C  ++gy G++C
  EFC36117.1 497 SEVCNSRGLCLDHD-SCSCdpQFGYGGANC 525
                 689*******7667.6***77778889999 PP

  == domain 7  score: 7.4 bits;  conditional E-value: 0.00064
       EGF_2   6 eiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                  +C g +G+C ++  +C C++ ++G  C
  EFC36117.1 535 GTCTGsRGVCTAPD-VCLCSPEFFGEFC 561
                 47999999999999.************9 PP

  == domain 8  score: 19.0 bits;  conditional E-value: 1.5e-07
       EGF_2   5 deiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g hGtC n+   C+C +gy G  C
  EFC36117.1 574 SSVCSGgHGTCLNTD-TCVCHDGYMGTLC 601
                 7889999****7666.8**********99 PP

  == domain 9  score: 20.9 bits;  conditional E-value: 3.9e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g+G+C++++  C+C++g++G +C
  EFC36117.1 614 SAVCSGRGSCIDAN-MCQCNNGFTGSNC 640
                 678*******9999.9************ PP

  == domain 10  score: 9.7 bits;  conditional E-value: 0.00012
       EGF_2   6 eiCgghGtCvnqcGq..CdCdsgyqGktC 32 
                   C+g G+C    G+  C+C+++y+G  C
  EFC36117.1 655 FVCSGKGICT---GVdtCVCQNNYTGYMC 680
                 67*******9...4334*********777 PP

  == domain 11  score: 9.1 bits;  conditional E-value: 0.00018
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+ghG+C  +  +C C   + G +C
  EFC36117.1 692 NETVCNGHGSCFPKD-KCNCLIEFVGEKC 719
                 5789*******9555.9***999999999 PP

  == domain 12  score: 11.7 bits;  conditional E-value: 2.8e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ Cgg+G C +++ +C C  +y G  C
  EFC36117.1 732 ESVCGGRGNCTELN-ECNCTENYLGEEC 758
                 689*******9888.9***********9 PP

  == domain 13  score: 15.9 bits;  conditional E-value: 1.4e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +Cg hG+C ++   C+C++ y G  C
  EFC36117.1 771 SFTCGAHGQCLDFD-TCQCEDYYLGSFC 797
                 789*******9999.9***********9 PP

  == domain 14  score: 9.2 bits;  conditional E-value: 0.00018
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+GtC ++   C C+++ +G +C
  EFC36117.1 810 SSVCSGRGTCLAFD-SCACSPSTFGGNC 836
                 689********999.7*********999 PP

  == domain 15  score: 18.9 bits;  conditional E-value: 1.6e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g G+C+n++ +C+C ++y+G+ C
  EFC36117.1 851 VCNGLGSCINPE-VCVCVPNYFGDFC 875
                 5***********.************* PP

  == domain 16  score: 19.7 bits;  conditional E-value: 8.9e-08
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ghG+C++++  C C+  + G+tC
  EFC36117.1 886 NsSNVCNGHGSCISFN-TCICEELFAGATC 914
                 34899********999.9************ PP

  == domain 17  score: 13.6 bits;  conditional E-value: 7.6e-06
       EGF_2    3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++++ C+g G+C ++   C+C+++ +G +C
  EFC36117.1 1154 TNGSVCSGKGSCTDLD-TCVCQTNSYGTDC 1182
                  56899*******9999.9************ PP

  == domain 18  score: 14.5 bits;  conditional E-value: 3.8e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C+ghG Cvn++  C+Cd +y   +C
  EFC36117.1 1196 FVCSGHGDCVNPN-TCSCDLHYNNTYC 1221
                  57********999.9*******99999 PP

  == domain 19  score: 7.7 bits;  conditional E-value: 0.0005
       EGF_2    7 iCgghGtCvnqcGqCdCds..gyqGktC 32  
                   C+ +G+C +++ +C C++  g+ G++C
  EFC36117.1 1236 VCNSRGQCKTFN-KCTCNTalGFGGDNC 1262
                  6********888.****65336777777 PP

  == domain 20  score: 19.9 bits;  conditional E-value: 8.1e-08
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ghG C +++  C C ++y+G +C
  EFC36117.1 1276 SVCSGHGECTAPN-TCACADHYSGTYC 1301
                  68********999.9************ PP

  == domain 21  score: 16.4 bits;  conditional E-value: 9.6e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G C +    C C++gy+G +C
  EFC36117.1 1314 SSVCSGNGRCSSYD-TCTCKTGYYGSDC 1340
                  689*******9444.8************ PP

  == domain 22  score: 18.1 bits;  conditional E-value: 2.8e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C  hG C++ + +C+C++gy+G +C
  EFC36117.1 1353 SKVCASHGECIDYN-NCKCQDGYFGSDC 1379
                  568*******8566.8************ PP

  == domain 23  score: 14.6 bits;  conditional E-value: 3.5e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   ++C+  GtC ++   C C s+y+G +C
  EFC36117.1 1392 TLACSSKGTCTALD-TCTCISNYTGSQC 1418
                  568*******9999.9************ PP

  == domain 24  score: 16.8 bits;  conditional E-value: 7.5e-07
       EGF_2    6 eiCgghGtCvnqcGqCdC..dsgyqGktC 32  
                  + C+ghG+C  ++  C C  +sgy+G++C
  EFC36117.1 1432 NVCNGHGKCWPLE-TCTCsaSSGYTGNYC 1459
                  68*******6567.8************** PP

  == domain 25  score: 11.3 bits;  conditional E-value: 3.9e-05
       EGF_2    8 Cgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  C    +G+C++++ +C+C  +y+G  C
  EFC36117.1 1475 CTSqtRGQCIAPN-NCSCAEHYYGTIC 1500
                  55555*****999.8*********988 PP

  == domain 26  score: 17.8 bits;  conditional E-value: 3.7e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +C++hG C +++  C C +gy+G +C
  EFC36117.1 1515 TCSNHGLCTAFN-TCTCAFGYSGSDC 1539
                  7********999.9************ PP

  == domain 27  score: 16.9 bits;  conditional E-value: 6.8e-07
       EGF_2    5 deiCgghGtCvnqcGq.CdCdsgyqGktC 32  
                  +++C+g+G+C+  + + C+C+sgy G++C
  EFC36117.1 1552 NNTCSGNGVCR--GYNwCSCKSGYIGNYC 1578
                  79*********..8777************ PP

  == domain 28  score: 9.1 bits;  conditional E-value: 0.00018
       EGF_2    5 deiCgg.hGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g hG C++ +  C C  +y G +C
  EFC36117.1 1591 ASVCSGkHGDCIAYE-TCACHEHYWGTDC 1618
                  578********9777.8************ PP

  == domain 29  score: 13.4 bits;  conditional E-value: 8.4e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C+ghG+C++   +C Cd+ y G+ C
  EFC36117.1 1633 YVCSGHGKCNAYD-KCTCDFDYDGDWC 1658
                  57********555.9*********988 PP

  == domain 30  score: 10.4 bits;  conditional E-value: 7.3e-05
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C g+G+C++   +C C +  +Gk+C
  EFC36117.1 1913 NETVCTGRGSCIDYD-VCTCRDISYGKDC 1940
                  4889*******9555.8************ PP

  == domain 31  score: 16.8 bits;  conditional E-value: 7.2e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ghG+C +   +C Cd++y+G  C
  EFC36117.1 1954 SVCSGHGKCTDHD-VCTCDTHYYGEWC 1979
                  67*******8777.9*********987 PP

  == domain 32  score: 9.8 bits;  conditional E-value: 0.00011
       EGF_2    6 eiCgghGtCvnqcGqCdC..dsgyqGktC 32  
                  e C+ +G+C  + ++C C  + gy+G +C
  EFC36117.1 1993 EVCNSRGVCP-LYNNCTCdlSYGYTGYDC 2020
                  57*******7.4789***999999**999 PP

  == domain 33  score: 13.2 bits;  conditional E-value: 9.8e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ghG+C  +   C C++ y+G++C
  EFC36117.1 2033 SKVCSGHGSCYLPD-SCNCSDLYFGDNC 2059
                  578*******8677.7************ PP

  == domain 34  score: 9.9 bits;  conditional E-value: 0.00011
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C  +G C  + + C C +gy+G +C
  EFC36117.1 2073 MVCTARGRCW-PYNTCNCTTGYYGVSC 2098
                  57*******6.4789**********99 PP

  == domain 35  score: 18.7 bits;  conditional E-value: 1.9e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+++GtC n  + CdC +gy+G +C
  EFC36117.1 2112 LGCSNRGTCSNI-NTCDCRDGYYGSNC 2137
                  45*******844.59************ PP

  == domain 36  score: 15.3 bits;  conditional E-value: 2.1e-06
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  s+++C+g GtC n++ +C C ++y+G +C
  EFC36117.1 2149 SSLTCNGLGTCKNTN-NCTCTTNYFGLNC 2176
                  3789*******8777.8*********999 PP

  == domain 37  score: 8.4 bits;  conditional E-value: 0.00031
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C  +G+C  + ++C C++gy+G  C
  EFC36117.1 2188 NSSVCTARGQCW-PYNNCTCSTGYTGLWC 2215
                  4789*******6.4889*********766 PP

  == domain 38  score: 10.9 bits;  conditional E-value: 5.2e-05
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++C+g G+C +  ++C C+ +y+G++C
  EFC36117.1 2229 STCNGLGSCLSY-NNCNCSKNYYGDNC 2254
                  68*******845.58************ PP

  == domain 39  score: 13.4 bits;  conditional E-value: 8.7e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                     C+g+G+C  + ++C C++gy+G +C
  EFC36117.1 2267 TKVCSGRGSCW-PYNNCTCKAGYFGSNC 2293
                  568*******6.4889************ PP

  == domain 40  score: 15.5 bits;  conditional E-value: 1.9e-06
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +++C g G+Cv++   C+C+++ +Gk+C
  EFC36117.1 2505 NkNSTCAGKGKCVDFD-TCVCNPNTYGKDC 2533
                  3689*********999.9************ PP

  == domain 41  score: 10.9 bits;  conditional E-value: 5.2e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ghG+C++q  +C+C+ g+ G  C
  EFC36117.1 2546 STVCSGHGSCISQD-KCSCSYGHNGTWC 2572
                  568********999.*********9887 PP

  == domain 42  score: 9.3 bits;  conditional E-value: 0.00017
       EGF_2    6 eiCgghGtCvnqcGqCdCds..gyqGktC 32  
                  + C+++G+C+ + ++C C+s  gy G++C
  EFC36117.1 2586 LVCSQRGVCE-FYNNCTCNStlGYGGPNC 2613
                  57*******8.6889***76447778887 PP

  == domain 43  score: 12.5 bits;  conditional E-value: 1.6e-05
       EGF_2    7 iCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                   C+g  +G+C +++  C+C+++y+G  C
  EFC36117.1 2624 LCSGlgRGQCLSPN-TCSCNAHYYGEFC 2650
                  588888****9999.9***********9 PP

  == domain 44  score: 16.4 bits;  conditional E-value: 9.7e-07
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +  C+g+G+C +  ++C C +g+ G++C
  EFC36117.1 2662 NvSKVCSGRGICSAY-NNCTCRAGFIGNQC 2690
                  56789*******955.58************ PP

  == domain 45  score: 13.0 bits;  conditional E-value: 1.2e-05
       EGF_2    4 s.deiCgghGtCvnqcGqCdC 23  
                  s +++C+g+G Cv+ + +C+C
  EFC36117.1 2938 SaNNTCSGRGRCVDYN-NCQC 2957
                  3489********9666.8*** PP

>> ArgoMid  Mid domain of argonaute
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0   0.00067         6      45      72 ..      97     124 ..      83     131 .. 0.80
   2 ?   -2.9   0.0      0.92   8.3e+03      34      65 ..     835     866 ..     824     867 .. 0.80
   3 ?    0.5   0.0     0.082   7.3e+02      46      69 ..    2544    2567 ..    2528    2570 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00067
     ArgoMid  45 kqlvkiskdvgisleekpeirkyadder 72 
                 ++++++++ +gi++ ++ + + y+ + +
  EFC36117.1  97 EMVQQVCNGHGICIGPDVCLCDYNYQGE 124
                 578999*****************87655 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.92
     ArgoMid  34 kvkenkledfikqlvkiskdvgisleekpeir 65 
                 +++ ++++  i++  ++++ +g +++++ +++
  EFC36117.1 835 NCEFTRCNGTINTDPHVCNGLGSCINPEVCVC 866
                 56666777777777899************998 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.082
     ArgoMid   46 qlvkiskdvgisleekpeirkyad 69  
                  ++  +++ +g +++++++ ++y +
  EFC36117.1 2544 NYSTVCSGHGSCISQDKCSCSYGH 2567
                  67889*****************76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2962 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       710  (0.0396006); expected 358.6 (0.02)
Passed bias filter:                      222  (0.0123822); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.43u 0.30s 00:00:01.73 Elapsed: 00:00:00.58
# Mc/sec: 15469.22
//
Query:       EFC36118.1  [L=2050]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.9e-06   26.1  42.8    4.8e-05   23.6   5.9   25.5 31  EGF_2     EGF-like domain
    0.00027   21.2   7.7    0.00027   21.2   7.7   25.9 28  EGF       EGF-like domain
  ------ inclusion threshold ------
       0.27   11.5   0.4          3    8.2   0.2    2.6  3  DUF2283   Protein of unknown function (DUF2283)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   9.3      0.07   4.2e+02       7      32 .]     330     365 ..     326     365 .. 0.74
   2 !   12.3   9.3   2.7e-05      0.16       5      32 .]     377     403 ..     370     403 .. 0.86
   3 ?   -3.8   1.4         3   1.8e+04       1      16 [.     421     438 ..     418     442 .. 0.49
   4 !   15.2   9.7   3.4e-06      0.02       5      32 .]     448     474 ..     444     474 .. 0.91
   5 ?   -2.9   0.4       1.6   9.3e+03      11      18 ..     496     503 ..     483     508 .. 0.72
   6 !   17.5  10.0   6.8e-07    0.0041       5      32 .]     511     537 ..     503     537 .. 0.91
   7 !   17.3  10.9   7.9e-07    0.0047       7      32 .]     554     578 ..     550     578 .. 0.93
   8 !   10.0   4.0   0.00015       0.9       7      32 .]     853     885 ..     848     885 .. 0.89
   9 !   23.6   5.9   8.1e-09   4.8e-05       6      32 .]     899     924 ..     893     924 .. 0.91
  10 !   14.7   9.7     5e-06      0.03       5      32 .]     962     988 ..     954     988 .. 0.87
  11 !   13.5  10.4   1.2e-05      0.07       5      32 .]    1027    1051 ..    1019    1051 .. 0.89
  12 !   13.8  11.1   9.7e-06     0.058       5      32 .]    1066    1092 ..    1062    1092 .. 0.86
  13 !   15.2   9.6   3.4e-06      0.02       5      32 .]    1105    1131 ..    1097    1131 .. 0.87
  14 ?   -5.4   2.6         3   1.8e+04      13      18 ..    1158    1163 ..    1142    1165 .. 0.60
  15 !    6.1  10.5    0.0025        15       7      32 .]    1174    1199 ..    1169    1199 .. 0.83
  16 !   12.5   9.6   2.5e-05      0.15       1      32 []    1205    1237 ..    1205    1237 .. 0.82
  17 ?   -5.1   2.1         3   1.8e+04       8      15 ..    1312    1319 ..    1306    1326 .. 0.48
  18 ?   -3.9   3.9         3   1.8e+04       7      23 ..    1339    1354 ..    1328    1358 .. 0.69
  19 ?   -6.2   7.3         3   1.8e+04       1      21 [.    1364    1383 ..    1364    1390 .. 0.68
  20 ?   -1.4   4.0      0.54   3.2e+03       7      18 ..    1462    1473 ..    1455    1484 .. 0.76
  21 ?   -8.0   5.3         3   1.8e+04      14      32 .]    1503    1527 ..    1502    1527 .. 0.59
  22 ?   -9.2   7.9         3   1.8e+04       1       1 [.    1564    1564 ..    1537    1589 .. 0.60
  23 ?   -2.6   0.8       1.3   7.8e+03      12      18 ..    1607    1613 ..    1606    1622 .. 0.71
  24 ?   -5.6   3.8         3   1.8e+04       8      21 ..    1632    1643 ..    1630    1649 .. 0.72
  25 ?   -4.0   2.6         3   1.8e+04       1      13 [.    1679    1690 ..    1679    1704 .. 0.82
  26 ?   -6.4   6.3         3   1.8e+04       1      21 [.    1795    1815 ..    1795    1820 .. 0.64
  27 ?   -3.7   1.6       2.9   1.7e+04       8      16 ..    1865    1874 ..    1860    1883 .. 0.67
  28 ?   -2.5   0.5       1.2   7.2e+03      13      22 ..    1916    1925 ..    1916    1931 .. 0.86
  29 ?   -4.4   2.2         3   1.8e+04       4      13 ..    1927    1939 ..    1924    1943 .. 0.69
  30 ?   -2.9   3.2       1.5   9.1e+03       1      21 [.    1954    1973 ..    1954    1978 .. 0.66
  31 ?   -2.8   3.2       1.5     9e+03       1      18 [.    1977    1991 ..    1973    2003 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.07
       EGF_2   7 iCgghGtCvn...qcG......q.CdCdsgyqGktC 32 
                  C+g G+C +   q+G      + C C++g +G +C
  EFC36118.1 330 VCSGVGQCSEflpQNGtsqnetVgCACKPGTSGINC 365
                 599999997633344577665426***********9 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.7e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+g+G+C++    C+C+  + G+ C
  EFC36118.1 377 SNACSGRGVCIDVD-ICECEGDWDGPEC 403
                 799*******9666.8************ PP

  == domain 3  score: -3.8 bits;  conditional E-value: 3
       EGF_2   1 Csas..deiCgghGtCvn 16 
                 Cs++  +  C  + tC++
  EFC36118.1 421 CSEHgfEVKCIAQDTCEH 438
                 333334444555555554 PP

  == domain 4  score: 15.2 bits;  conditional E-value: 3.4e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g G C +q+ +C+C++g+ G++C
  EFC36118.1 448 ASVCSGVGECSSQN-NCSCSFGFIGNNC 474
                 568********999.8************ PP

  == domain 5  score: -2.9 bits;  conditional E-value: 1.6
       EGF_2  11 hGtCvnqc 18 
                  +tCv++c
  EFC36118.1 496 VETCVHKC 503
                 46777666 PP

  == domain 6  score: 17.5 bits;  conditional E-value: 6.8e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG+Cv+q   C+Cd  ++G +C
  EFC36118.1 511 SSVCSGHGVCVAQD-FCYCDKAHYGSDC 537
                 578********999.9************ PP

  == domain 7  score: 17.3 bits;  conditional E-value: 7.9e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g G+C++q+ +C Cdsgy G +C
  EFC36118.1 554 VCSGKGKCISQN-NCACDSGYGGSQC 578
                 6********999.8************ PP

  == domain 8  score: 10.0 bits;  conditional E-value: 0.00015
       EGF_2   7 iCgghGtCvnqcG........qCdCdsgyqGktC 32 
                  C+ +G C + ++        qC+C +gy+G +C
  EFC36118.1 853 SCN-GGNCSRYTNvelnleltQCSCLPGYSGYDC 885
                 587.5***988889****9999***********9 PP

  == domain 9  score: 23.6 bits;  conditional E-value: 8.1e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ghGtCv++   C+C++gy+G+ C
  EFC36118.1 899 AVCSGHGTCVKPD-MCSCQDGYTGNMC 924
                 57********999.9**********99 PP

  == domain 10  score: 14.7 bits;  conditional E-value: 5e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g GtCv+ + +C+C  g++G +C
  EFC36118.1 962 ANVCSGEGTCVSMN-NCSCHYGRYGVNC 988
                 789********787.8**********99 PP

  == domain 11  score: 13.5 bits;  conditional E-value: 1.2e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g+G+C     +C+C+ g+ G +C
  EFC36118.1 1027 TLVCSGNGVCT--D-KCYCNLGWKGSNC 1051
                  578*******9..8.9************ PP

  == domain 12  score: 13.8 bits;  conditional E-value: 9.7e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g G C + +++C+C+ g +G  C
  EFC36118.1 1066 SSVCSGSGNCTA-NNVCSCNEGAYGSEC 1092
                  789*******84.559***********9 PP

  == domain 13  score: 15.2 bits;  conditional E-value: 3.4e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g+G Cv+    C+C+  ++G +C
  EFC36118.1 1105 ASVCSGRGACVDND-DCSCNETWTGSNC 1131
                  689*******9666.8************ PP

  == domain 14  score: -5.4 bits;  conditional E-value: 3
       EGF_2   13 tCvnqc 18  
                  tCv+qc
  EFC36118.1 1158 TCVDQC 1163
                  455555 PP

  == domain 15  score: 6.1 bits;  conditional E-value: 0.0025
       EGF_2    7 iCgghGtCvnqc.GqC.dCdsgyqGktC 32  
                   C+g+G+C   + + C  C +gy+G +C
  EFC36118.1 1174 VCSGRGKCT--GyNTCtTCTNGYSGQYC 1199
                  7*******9..6347955********** PP

  == domain 16  score: 12.5 bits;  conditional E-value: 2.5e-05
       EGF_2    1 CsasdeiCgghGtCvnqc.G..qCdCdsgyqGktC 32  
                  Cs+  ++C ++GtC +   G   C+C+ g+ GktC
  EFC36118.1 1205 CST--LTCENNGTCFHYKdGseTCVCPLGFKGKTC 1237
                  874..79*******744447666************ PP

  == domain 17  score: -5.1 bits;  conditional E-value: 3
       EGF_2    8 CgghGtCv 15  
                  C ++ +C 
  EFC36118.1 1312 CMQDSQCS 1319
                  33333444 PP

  == domain 18  score: -3.9 bits;  conditional E-value: 3
       EGF_2    7 iCgghGtCvnqcGqCdC 23  
                  +C  ++ C  + G+ +C
  EFC36118.1 1339 ECTSNENCT-SIGKHYC 1354
                  488888886.4577555 PP

  == domain 19  score: -6.2 bits;  conditional E-value: 3
       EGF_2    1 CsasdeiCgghGtCvnqcGq..C 21  
                  C + d++C+  G+    c++  C
  EFC36118.1 1364 CAN-DTQCQSYGYSQ--CNNsiC 1383
                  766.68899999755..542225 PP

  == domain 20  score: -1.4 bits;  conditional E-value: 0.54
       EGF_2    7 iCgghGtCvnqc 18  
                   C + GtC+ +c
  EFC36118.1 1462 KCTNIGTCEVEC 1473
                  69******9888 PP

  == domain 21  score: -8.0 bits;  conditional E-value: 3
       EGF_2   14 C.vnqcG....qC.dCdsgyq..GktC 32  
                  C v  cG     C +C sgy   G  C
  EFC36118.1 1503 CdV--CGedriTCmKCASGYVwdGTEC 1527
                  755..8855544745888876556666 PP

  == domain 22  score: -9.2 bits;  conditional E-value: 3
       EGF_2    1 C 1   
                  C
  EFC36118.1 1564 C 1564
                  1 PP

  == domain 23  score: -2.6 bits;  conditional E-value: 1.3
       EGF_2   12 GtCvnqc 18  
                  G+Cv++c
  EFC36118.1 1607 GYCVEEC 1613
                  7888555 PP

  == domain 24  score: -5.6 bits;  conditional E-value: 3
       EGF_2    8 CgghGtCvnqcGqC 21  
                  C+  G+C ++ G C
  EFC36118.1 1632 CN-SGKCGHLRG-C 1643
                  65.688877777.5 PP

  == domain 25  score: -4.0 bits;  conditional E-value: 3
       EGF_2    1 CsasdeiCgghGt 13  
                  C ++ ++C ++G+
  EFC36118.1 1679 CFNN-TDCEQRGI 1690
                  8885.77999996 PP

  == domain 26  score: -6.4 bits;  conditional E-value: 3
       EGF_2    1 CsasdeiCgghGt..CvnqcGq.C 21  
                  Csa d++C + G   C+   G+ C
  EFC36118.1 1795 CSA-DTDCTVKGFtfCN--SGKkC 1815
                  998.5889999852255..44325 PP

  == domain 27  score: -3.7 bits;  conditional E-value: 2.9
       EGF_2    8 Cgg.hGtCvn 16  
                  C+   G Cv+
  EFC36118.1 1865 CSTsKGRCVE 1874
                  5555777764 PP

  == domain 28  score: -2.5 bits;  conditional E-value: 1.2
       EGF_2   13 tCvnqcGqCd 22  
                  tC+ ++G+C+
  EFC36118.1 1916 TCDMTTGRCK 1925
                  7999999996 PP

  == domain 29  score: -4.4 bits;  conditional E-value: 3
       EGF_2    4 s...deiCgghGt 13  
                      d +Cg +G+
  EFC36118.1 1927 EcvsDIECGTNGK 1939
                  4445789999997 PP

  == domain 30  score: -2.9 bits;  conditional E-value: 1.5
       EGF_2    1 CsasdeiCgghGtCvnqcGqC 21  
                  Cs+s ++C   G+   ++G C
  EFC36118.1 1954 CSNS-SECTKTGYTSCTNGIC 1973
                  8774.7888888744336766 PP

  == domain 31  score: -2.8 bits;  conditional E-value: 1.5
       EGF_2    1 CsasdeiCgghGtCvnqc 18  
                  C + d++C g Gt +  c
  EFC36118.1 1977 CVN-DLECVGKGTGI--C 1991
                  544.79999977766..4 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   1.9     0.026   1.6e+02       6      32 .]     331     364 ..     325     364 .. 0.79
   2 !    8.7   1.1   0.00036       2.1       3      30 ..     377     400 ..     375     402 .. 0.84
   3 ?   -1.3   1.0      0.49   2.9e+03       3      13 ..     416     431 ..     415     445 .. 0.73
   4 ?   -3.1   5.7       1.7     1e+04       6      32 .]     451     473 ..     440     473 .. 0.81
   5 ?   -4.4   1.2         3   1.8e+04       1      15 [.     480     493 ..     480     495 .. 0.66
   6 ?   -2.7   4.6       1.3   7.9e+03       6      24 ..     514     528 ..     503     533 .. 0.73
   7 !    5.8   4.5    0.0029        18       4      31 ..     551     576 ..     549     577 .. 0.86
   8 !    5.6   1.4    0.0033        20       6      30 ..     854     882 ..     848     882 .. 0.78
   9 !   15.6   3.2   2.5e-06     0.015       6      31 ..     901     922 ..     896     922 .. 0.92
  10 ?   -6.6   4.4         3   1.8e+04       1      23 [.     924     945 ..     924     945 .. 0.73
  11 ?    2.4   4.1     0.033     2e+02       4      30 ..     963     985 ..     958     987 .. 0.78
  12 !    4.3   2.9    0.0087        52       6      32 .]    1030    1050 ..    1023    1050 .. 0.83
  13 ?   -4.5   4.3         3   1.8e+04       3      30 ..    1077    1089 ..    1064    1098 .. 0.62
  14 ?    3.8   3.0     0.012        71       4      31 ..    1103    1129 ..    1097    1130 .. 0.83
  15 ?   -5.4   8.1         3   1.8e+04       6      31 ..    1175    1197 ..    1170    1198 .. 0.64
  16 !   21.2   7.7   4.4e-08   0.00027       1      32 []    1205    1236 ..    1205    1236 .. 0.97
  17 ?   -5.4   9.4         3   1.8e+04       1      22 [.    1346    1370 ..    1340    1374 .. 0.72
  18 ?   -2.2   1.9      0.95   5.7e+03       4      27 ..    1379    1396 ..    1375    1402 .. 0.75
  19 ?   -2.3   3.6      0.98   5.9e+03       5      23 ..    1420    1438 ..    1416    1438 .. 0.77
  20 ?   -2.7   5.2       1.3   7.8e+03       1      22 [.    1455    1479 ..    1455    1480 .. 0.71
  21 ?   -3.5   4.1       2.3   1.4e+04       1      22 [.    1473    1503 ..    1473    1504 .. 0.79
  22 ?   -2.0   2.7      0.79   4.7e+03       4      22 ..    1544    1564 ..    1537    1565 .. 0.70
  23 ?   -7.6   5.0         3   1.8e+04       1      22 [.    1573    1597 ..    1573    1598 .. 0.48
  24 ?   -2.7   5.5       1.3     8e+03       1      23 [.    1622    1650 ..    1622    1650 .. 0.70
  25 ?   -4.4   1.7         3   1.8e+04       6      22 ..    1737    1752 ..    1733    1753 .. 0.73
  26 ?   -5.2   7.2         3   1.8e+04       1      20 [.    1872    1890 ..    1872    1909 .. 0.91
  27 ?   -7.3   6.8         3   1.8e+04       1      20 [.    1949    1965 ..    1949    1980 .. 0.70
  28 ?   -4.2   2.7         3   1.8e+04       1       9 [.    2010    2019 ..    2003    2027 .. 0.61

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.026
                 STTT-EE..EEET.....TTEEEEEECTTEESTT CS
         EGF   6 CsngGtC..vdtg.....rggytCiCpeGytGkr 32 
                 Cs+ G C  + ++     +++  C C++G +G++
  EFC36118.1 331 CSGVGQCseFLPQngtsqNETVGCACKPGTSGIN 364
                 99999997644447777799999******99975 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00036
                 STTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytG 30 
                 +n Cs++G C+d+     +C+C   ++G
  EFC36118.1 377 SNACSGRGVCIDVD----ICECEGDWDG 400
                 577***********....****866666 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.49
                 STT..STTT-E...EE CS
         EGF   3 pnp..CsngGt...Cv 13 
                 +np  Cs +G+   C+
  EFC36118.1 416 KNPlaCSEHGFevkCI 431
                 6888899999877774 PP

  == domain 4  score: -3.1 bits;  conditional E-value: 1.7
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs+ G+C    +   +C C+ G+ G++
  EFC36118.1 451 CSGVGEC----SSQNNCSCSFGFIGNN 473
                 9999999....577899**99999986 PP

  == domain 5  score: -4.4 bits;  conditional E-value: 3
                 GCSTT.STTT-EEEEE CS
         EGF   1 Cspnp.CsngGtCvdt 15 
                 C +n  C  gG+C+++
  EFC36118.1 480 CVSNMgC--GGECFYL 493
                 6663348..888*876 PP

  == domain 6  score: -2.7 bits;  conditional E-value: 1.3
                 STTT-EEEEETTTEEEEEE CS
         EGF   6 CsngGtCvdtgrggytCiC 24 
                 Cs++G Cv        C C
  EFC36118.1 514 CSGHGVCVAQD----FCYC 528
                 *******8655....6666 PP

  == domain 7  score: 5.8 bits;  conditional E-value: 0.0029
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +p  Cs+ G+C++      +C C++Gy G+
  EFC36118.1 551 DPkvCSGKGKCISQN----NCACDSGYGGS 576
                 7888*******7777....********996 PP

  == domain 8  score: 5.6 bits;  conditional E-value: 0.0033
                 STTT-EE...EEET..TTEEEEEECTTEES CS
         EGF   6 CsngGtC...vdtg..rggytCiCpeGytG 30 
                 C ngG C    +++   +  +C C +Gy+G
  EFC36118.1 854 C-NGGNCsryTNVElnLELTQCSCLPGYSG 882
                 6.788896553333668899********99 PP

  == domain 9  score: 15.6 bits;  conditional E-value: 2.5e-06
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++GtCv +      C C+ GytG+
  EFC36118.1 901 CSGHGTCVKPD----MCSCQDGYTGN 922
                 ***********....**********6 PP

  == domain 10  score: -6.6 bits;  conditional E-value: 3
                 GCSTTSTTT-EEEEETTTEEEEE CS
         EGF   1 CspnpCsngGtCvdtgrggytCi 23 
                 C  ++C + + C   g ++ +Ci
  EFC36118.1 924 CQNYTCYGSAGCTMFG-NDAKCI 945
                 7777788777787777.888885 PP

  == domain 11  score: 2.4 bits;  conditional E-value: 0.033
                 TTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytG 30 
                 n Cs+ GtCv+      +C C  G  G
  EFC36118.1 963 NVCSGEGTCVSMN----NCSCHYGRYG 985
                 44*******8888....9999877666 PP

  == domain 12  score: 4.3 bits;  conditional E-value: 0.0087
                  STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGkr 32  
                  Cs++G C  t     +C C  G++G++
  EFC36118.1 1030 CSGNGVC--TD----KCYCNLGWKGSN 1050
                  *******..55....6*********86 PP

  == domain 13  score: -4.5 bits;  conditional E-value: 3
                  STTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytG 30  
                   n+                C C eG  G
  EFC36118.1 1077 ANN---------------VCSCNEGAYG 1089
                  333...............4667666544 PP

  == domain 14  score: 3.8 bits;  conditional E-value: 0.012
                  TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np...CsngGtCvdtgrggytCiCpeGytGk 31  
                  n+   Cs++G Cvd+      C C e +tG+
  EFC36118.1 1103 NNasvCSGRGACVDND----DCSCNETWTGS 1129
                  77788*********99....89998888886 PP

  == domain 15  score: -5.4 bits;  conditional E-value: 3
                  STTT-EEEEETTTEEEE.EECTTEEST CS
         EGF    6 CsngGtCvdtgrggytC.iCpeGytGk 31  
                  Cs++G+C  tg    tC +C++Gy+G 
  EFC36118.1 1175 CSGRGKC--TG-YN-TCtTCTNGYSGQ 1197
                  9999999..33.33.342688888885 PP

  == domain 16  score: 21.2 bits;  conditional E-value: 4.4e-08
                  GCSTTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    1 CspnpCsngGtCvdtgrggytCiCpeGytGkr 32  
                  Cs  +C n+GtC+ +++g+ tC Cp G++Gk+
  EFC36118.1 1205 CSTLTCENNGTCFHYKDGSETCVCPLGFKGKT 1236
                  9999**************************96 PP

  == domain 17  score: -5.4 bits;  conditional E-value: 3
                  GCS.TT..STTT-EEEEET.TTEEEE CS
         EGF    1 Csp.np..CsngGtCvdtg.rggytC 22  
                  C++ ++  Cs gG C  ++  ++ +C
  EFC36118.1 1346 CTSiGKhyCSDGG-CKMYScANDTQC 1370
                  5555556699999.966666777777 PP

  == domain 18  score: -2.2 bits;  conditional E-value: 0.95
                  TT..STTT-EEEEETTTEEEEEECTT CS
         EGF    4 np..CsngGtCvdtgrggytCiCpeG 27  
                  n+  C n   C++++      +Cp+G
  EFC36118.1 1379 NNsiCRNE--CLESK------DCPVG 1396
                  45689999..99999......88888 PP

  == domain 19  score: -2.3 bits;  conditional E-value: 0.98
                  TSTTT-EEEEET.TTEEEEE CS
         EGF    5 pCsngGtCvdtg.rggytCi 23  
                  +C+ ++ C d++  g+++C+
  EFC36118.1 1420 NCKSNADC-DSPfTGTPKCD 1438
                  5*******.66669999996 PP

  == domain 20  score: -2.7 bits;  conditional E-value: 1.3
                  GCS.TT..STTT-EEEEETTTEEEE CS
         EGF    1 Csp.np..CsngGtCvdtgrggytC 22  
                  C p +   C n GtC     ++ +C
  EFC36118.1 1455 CYPyHYskCTNIGTCEVECTNHTNC 1479
                  77744467*******6555777777 PP

  == domain 21  score: -3.5 bits;  conditional E-value: 2.3
                  GCSTT.STTT-E..EEEET......TTEEEE CS
         EGF    1 Cspnp.CsngGt..Cvdtg......rggytC 22  
                  C+ ++ C+  G+  C +++      r++ +C
  EFC36118.1 1473 CTNHTnCKEFGFerCGSNPnntaeyRNTTQC 1503
                  888666******99*8888777777777777 PP

  == domain 22  score: -2.0 bits;  conditional E-value: 0.79
                  TT.STTT-EEEEET.TTEEEE CS
         EGF    4 np.CsngGtCvdtg.rggytC 22  
                   p Cs  G C ++    +++C
  EFC36118.1 1544 KPlCSSEGLCGYVAcQYDFEC 1564
                  359*******76666677777 PP

  == domain 23  score: -7.6 bits;  conditional E-value: 3
                  GCSTT....STTT-EEEEETTTEEEE CS
         EGF    1 Cspnp....CsngGtCvdtgrggytC 22  
                  C++++    C+ +  C  ++ ++++C
  EFC36118.1 1573 CTDGKcsivCHSDSDC-ASQKTSPRC 1597
                  7777733334444444.333566666 PP

  == domain 24  score: -2.7 bits;  conditional E-value: 1.3
                  GCS.TT....STTT-EE..EEETTTEEEEE CS
         EGF    1 Csp.np....CsngGtC..vdtgrggytCi 23  
                  C++ np    C n G+C  +++ +++ +C+
  EFC36118.1 1622 CTKkNPllpsC-NSGKCghLRGCWTDDSCQ 1650
                  77767788899.777895444449998986 PP

  == domain 25  score: -4.4 bits;  conditional E-value: 3
                  STTT-EEEEETTTEEEE CS
         EGF    6 CsngGtCvdtgrggytC 22  
                  C  + +C +t+ ++++C
  EFC36118.1 1737 CFANWECSSTP-DRPKC 1752
                  77777788999.99888 PP

  == domain 26  score: -5.2 bits;  conditional E-value: 3
                  GCSTTSTTT-EEEEETTTEE CS
         EGF    1 CspnpCsngGtCvdtgrggy 20  
                  C + pCs +  C++tg  +y
  EFC36118.1 1872 CVELPCSSDSDCIYTG-YSY 1890
                  9999*****99**999.665 PP

  == domain 27  score: -7.3 bits;  conditional E-value: 3
                  GCSTTSTTT-EEEEETTTEE CS
         EGF    1 CspnpCsngGtCvdtgrggy 20  
                  C   +Csn  +C  t   gy
  EFC36118.1 1949 CVAKTCSNSSECTKT---GY 1965
                  666668888888433...33 PP

  == domain 28  score: -4.2 bits;  conditional E-value: 3
                  GCSTT.STTT CS
         EGF    1 Cspnp.Csng 9   
                  Cs+++ C n 
  EFC36118.1 2010 CSSTNyCYNT 2019
                  6664446664 PP

>> DUF2283  Protein of unknown function (DUF2283)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.2    0.0005         3       2      13 ..     137     148 ..     136     158 .. 0.82
   2 ?   -1.4   0.0      0.47   2.8e+03      30      40 ..     279     289 ..     269     290 .. 0.85
   3 ?   -1.0   0.0      0.36   2.1e+03       3      17 ..     687     701 ..     686     713 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0005
     DUF2283   2 itYDpeaDalYI 13 
                 itYDp +D+lY 
  EFC36118.1 137 ITYDPTTDILYF 148
                 9**********6 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.47
     DUF2283  30 iilDfDedGrl 40 
                 i lDfD+ G++
  EFC36118.1 279 ISLDFDQFGNI 289
                 679******98 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.36
     DUF2283   3 tYDpeaDalYIylse 17 
                 tY pe+D+ Y+  s 
  EFC36118.1 687 TYVPETDTYYVSMSG 701
                 899********9843 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2050 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       918  (0.051202); expected 358.6 (0.02)
Passed bias filter:                      219  (0.0122148); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.10u 0.34s 00:00:01.44 Elapsed: 00:00:00.63
# Mc/sec: 9774.83
//
Query:       EFC36119.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-05   24.1  41.6      0.062   13.7   3.5    6.7  8  LRR_4     Leucine Rich repeats (2 copies)
     0.0046   16.9   0.3     0.0046   16.9   0.3    7.1  8  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
      0.091   13.1   0.0       0.16   12.3   0.0    1.3  1  DUF2690   Protein of unknown function (DUF2690)
       0.12   13.0  26.4        4.3    8.3   0.4    8.8  8  LRR_1     Leucine Rich Repeat
       0.13   12.1  40.3      0.044   13.5   3.8    6.9  7  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       2.7   9.6e+03      23      32 ..     132     141 ..     124     145 .. 0.68
   2 ?   -2.1   0.1       1.7     6e+03      23      30 ..     185     192 ..     177     205 .. 0.66
   3 !    9.9   0.6   0.00027      0.98       2      32 ..     250     285 ..     249     292 .. 0.82
   4 !    9.6   5.2   0.00034       1.2       1      31 [.     303     338 ..     303     349 .. 0.82
   5 !    9.5   1.3   0.00038       1.4       2      38 ..     355     388 ..     354     392 .. 0.75
   6 !   11.9   8.0   6.8e-05      0.24       1      36 [.     377     417 ..     377     426 .. 0.73
   7 !   13.7   3.5   1.7e-05     0.062       2      42 ..     405     449 ..     404     451 .. 0.84
   8 !    8.7   0.1   0.00065       2.3       2      28 ..     432     462 ..     431     463 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.7
                 TT--EEE-.- CS
       LRR_4  23 pnLkeLdLsg 32 
                 +nLk++ +sg
  EFC36119.1 132 TNLKTVIMSG 141
                 6777775554 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.7
                 TT--EEE- CS
       LRR_4  23 pnLkeLdL 30 
                  +L++L +
  EFC36119.1 185 RDLTSLEI 192
                 45666666 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00027
                 S--EEE--SS-.....--E-S-HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNq.....ltdiplleklpnLkeLdLsg 32 
                 n ++L+L + +     lt++++ e +++L +L+Ls+
  EFC36119.1 250 NVKYLNLKGSCinsevLTSLSNSEHMTKLIYLNLSS 285
                 78999999623346999*****999*********76 PP

  == domain 4  score: 9.6 bits;  conditional E-value: 0.00034
                 SS--EEE--SS---E-S-....HH..H-TT--EEE-. CS
       LRR_4   1 pnLevLdLsnNqltdipl....le..klpnLkeLdLs 31 
                 +nL++L L nN+++ +++    l+  +l nL++L++s
  EFC36119.1 303 TNLKELALENNNIS-LSGmstiLNskQLSNLRKLSIS 338
                 7*************.889888866856********95 PP

  == domain 5  score: 9.5 bits;  conditional E-value: 0.00038
                 S--EEE--SS---E-S-HH..H-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitd 38 
                 n e+L Ls     +++l+e  ++++Lk+LdLs+     +
  EFC36119.1 355 NIETLILSRSTF-SLELFEmiNIKSLKHLDLSST----S 388
                 778899996344.488877777999******886....4 PP

  == domain 6  score: 11.9 bits;  conditional E-value: 6.8e-05
                 SS--EEE--SS---E-S-.HH......H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.le......klpnLkeLdLsgNnli 36 
                 ++L++LdLs++ l d  + l+       l nL++L+L  Nnl 
  EFC36119.1 377 KSLKHLDLSSTSLND--GhLQlisssiYLSNLTSLNLDYNNLS 417
                 68********99665..44333344547*********888543 PP

  == domain 7  score: 13.7 bits;  conditional E-value: 1.7e-05
                 S--EEE--SS---E-S-..HH..H.-TT--EEE-.-S-----GGGG CS
       LRR_4   2 nLevLdLsnNqltdipl..le..k.lpnLkeLdLsgNnlitdldeL 42 
                 nL++L+L  N+l+d +   ++  + l nL+ +++ + nli  +d++
  EFC36119.1 405 NLTSLNLDYNNLSDTGIidFAnsSiLSNLEIISI-RDNLIIFIDPI 449
                 9************999966447888*********.66699888876 PP

  == domain 8  score: 8.7 bits;  conditional E-value: 0.00065
                 S--EEE--SS---E-S-...HH.H-TT--EE CS
       LRR_4   2 nLevLdLsnNqltdipl...le.klpnLkeL 28 
                 nLe++++++N +  i++   l+ k+p+Lk++
  EFC36119.1 432 NLEIISIRDNLIIFIDPievLQsKIPSLKKI 462
                 9****************6555556****986 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1      0.03   1.1e+02       3      18 ..     249     264 ..     249     270 .. 0.83
   2 ?    0.6   0.2      0.21   7.5e+02       2      13 ..     275     286 ..     274     287 .. 0.82
   3 !    8.9   0.7   0.00048       1.7       2      23 ..     302     323 ..     301     324 .. 0.90
   4 ?   -1.8   0.1       1.3   4.7e+03       3      11 ..     330     338 ..     328     338 .. 0.84
   5 ?   -3.3   0.0         4   1.4e+04       2      12 ..     353     363 ..     353     366 .. 0.82
   6 !    5.3   0.6     0.007        25       4      17 ..     378     391 ..     375     392 .. 0.86
   7 !   16.9   0.3   1.3e-06    0.0046       3      24 .]     404     425 ..     402     425 .. 0.89
   8 ?   -1.7   0.2       1.2   4.2e+03       3      15 ..     431     443 ..     430     443 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.03
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 +++++L+L+g +I+ e
  EFC36119.1 249 SNVKYLNLKGSCINSE 264
                 579*********9877 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.21
       LRR_6   2 nthLteLdLsgN 13 
                  t+L +L+Ls+ 
  EFC36119.1 275 MTKLIYLNLSST 286
                 68999*****85 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.00048
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  t+L+eL L  N+I+ +G++ +
  EFC36119.1 302 LTNLKELALENNNISLSGMSTI 323
                 589***************9876 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 1.3
       LRR_6   3 thLteLdLs 11 
                 ++L++L++s
  EFC36119.1 330 SNLRKLSIS 338
                 89****997 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 4
       LRR_6   2 nthLteLdLsg 12 
                 n ++++L Ls 
  EFC36119.1 353 NANIETLILSR 363
                 67899999996 PP

  == domain 6  score: 5.3 bits;  conditional E-value: 0.007
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +L++LdLs+  ++D
  EFC36119.1 378 SLKHLDLSSTSLND 391
                 8*******998887 PP

  == domain 7  score: 16.9 bits;  conditional E-value: 1.3e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L+L +N+++D G++ +a
  EFC36119.1 404 SNLTSLNLDYNNLSDTGIIDFA 425
                 89***************98765 PP

  == domain 8  score: -1.7 bits;  conditional E-value: 1.2
       LRR_6   3 thLteLdLsgNdI 15 
                 ++L+  ++++N I
  EFC36119.1 431 SNLEIISIRDNLI 443
                 68999******76 PP

>> DUF2690  Protein of unknown function (DUF2690)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   4.3e-05      0.16      13      49 ..     260     297 ..     255     328 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.3e-05
     DUF2690  13 Caadgvtakstavvets.tvelrysskCkaAWakitla 49 
                 C ++ v ++ ++ +  +  ++l +ss+C+ AW  i l+
  EFC36119.1 260 CINSEVLTSLSNSEHMTkLIYLNLSSTCRMAWDCIILS 297
                 6666666666666665558*************998873 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       4.4   1.6e+04       2      16 ..     187     201 ..     186     203 .. 0.74
   2 ?    0.2   0.0      0.55     2e+03       2      12 ..     215     225 ..     214     248 .. 0.72
   3 ?    1.5   0.3      0.21   7.4e+02       1      14 [.     250     263 ..     250     272 .. 0.62
   4 ?    1.6   0.0      0.18   6.6e+02       1      12 [.     277     288 ..     277     301 .. 0.77
   5 ?    2.7   1.3      0.08   2.9e+02       1      13 [.     304     318 ..     304     343 .. 0.73
   6 ?    8.3   0.4    0.0012       4.3       1      19 [.     378     400 ..     378     402 .. 0.82
   7 ?    7.3   0.5    0.0025         9       1      17 [.     405     421 ..     405     431 .. 0.77
   8 ?    1.0   0.1      0.29     1e+03       1      13 [.     432     444 ..     432     461 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 4.4
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L++L ++  ++ g++
  EFC36119.1 187 LTSLEINKSIIAGIQ 201
                 889999888876655 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.55
       LRR_1   2 LrhLdLsnnpl 12 
                 L++  ++++++
  EFC36119.1 215 LEKVTITHCFP 225
                 89999****98 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.21
       LRR_1   1 nLrhLdLsnnpllg 14 
                 n ++L+L + ++ +
  EFC36119.1 250 NVKYLNLKGSCINS 263
                 679****7777633 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.18
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L +L+Ls+ + 
  EFC36119.1 277 KLIYLNLSSTCR 288
                 799****99876 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.08
       LRR_1   1 nLrhLdLsnnpl..l 13 
                 nL++L L+nn++  +
  EFC36119.1 304 NLKELALENNNIslS 318
                 8*********98440 PP

  == domain 6  score: 8.3 bits;  conditional E-value: 0.0012
       LRR_1   1 nLrhLdLsnnpl....lglppns 19 
                 +L+hLdLs+ +l    l+l+++s
  EFC36119.1 378 SLKHLDLSSTSLndghLQLISSS 400
                 6**********977777777776 PP

  == domain 7  score: 7.3 bits;  conditional E-value: 0.0025
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL++L+L +n+l++ ++
  EFC36119.1 405 NLTSLNLDYNNLSDTGI 421
                 8**********955443 PP

  == domain 8  score: 1.0 bits;  conditional E-value: 0.29
       LRR_1   1 nLrhLdLsnnpll 13 
                 nL+ + +++n ++
  EFC36119.1 432 NLEIISIRDNLII 444
                 8*********983 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       1.1   3.8e+03       3      29 ..     110     136 ..     108     140 .. 0.79
   2 ?   -1.0   0.0      0.43   1.5e+03      42      52 ..     181     191 ..     177     203 .. 0.60
   3 ?    4.4   2.1    0.0087        31      25      58 ..     249     285 ..     243     288 .. 0.68
   4 ?    6.5   4.4    0.0019       6.8      22      53 ..     300     331 ..     294     339 .. 0.70
   5 ?    3.9   2.9     0.012        45       2      61 .]     331     389 ..     330     389 .. 0.66
   6 ?    6.7   9.4    0.0017       5.9      24      61 .]     376     416 ..     354     416 .. 0.83
   7 ?   13.5   3.8   1.2e-05     0.044       1      42 [.     404     448 ..     404     454 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.1
                 -SEEE-TTS--SEE-TTSSTT-TT--E CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkv 29 
                 ++sL+L+   +++l ++   g +nLk+
  EFC36119.1 110 VSSLVLRAKDIKALLKDNVLGGTNLKT 136
                 678999999999988888888888876 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.43
                 GGGGTT--S-. CS
       LRR_8  42 pgafsgLpsLr 52 
                 ++ f++L+sL+
  EFC36119.1 181 NEIFRDLTSLE 191
                 44444444443 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.0087
                 TT--EEE--SS---G...GGGGGGTT--S-.EEE--S CS
       LRR_8  25 snLkvLdLsnNlltt...lspgafsgLpsLrsLdLsg 58 
                 sn+k+L+L+  ++++    s    +++++L +L+Ls+
  EFC36119.1 249 SNVKYLNLKGSCINSevlTSLSNSEHMTKLIYLNLSS 285
                 6889999999888873222333445677777777776 PP

  == domain 4  score: 6.5 bits;  conditional E-value: 0.0019
                 TT-TT--EEE--SS---GGGGGGGTT--S-.E CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrs 53 
                 ++l+nLk+L L nN+++     ++ + ++L  
  EFC36119.1 300 SSLTNLKELALENNNISLSGMSTILNSKQLSN 331
                 67999999999999998776666654444433 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.012
                 T-SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 nL++L++s    l ++  +a   + n ++L Ls+ + +  l    + + +sL++LdLs++ L
  EFC36119.1 331 NLRKLSISPADfLLDIYEKATP-NANIETLILSRSTFSLeL--FEMINIKSLKHLDLSSTSL 389
                 6666666665556666666666.478888888888555433..3788889999999988765 PP

  == domain 6  score: 6.7 bits;  conditional E-value: 0.0017
                 -TT--EEE--SS---GGGGGGGTT...--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsg...LpsLrsLdLsgNrL 61 
                  ++Lk+LdLs+ +l+  + + +s+   L++L+sL+L++N+L
  EFC36119.1 376 IKSLKHLDLSSTSLNDGHLQLISSsiyLSNLTSLNLDYNNL 416
                 689********99998777766544449***********98 PP

  == domain 7  score: 13.5 bits;  conditional E-value: 1.2e-05
                 TT-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS---GGGG CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllttlsp 42 
                 +nLtsL+L+ N+l++ +   F +   lsnL+++++++Nl+ +++p
  EFC36119.1 404 SNLTSLNLDYNNLSDTGIIDFANssiLSNLEIISIRDNLIIFIDP 448
                 69***********8876666655559**************99998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 2628.95
//
Query:       EFC36120.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-30  105.8   0.2    3.2e-30  104.4   0.2    1.8  1  E2F_CC-MB       E2F transcription factor CC-MB domain
    1.3e-25   89.2   0.1    3.7e-25   87.8   0.1    1.8  1  E2F_TDP         E2F/DP family winged-helix DNA-binding domain
  ------ inclusion threshold ------
      0.028   14.3   0.0      0.056   13.3   0.0    1.4  1  TrmB            Sugar-specific transcriptional regulator TrmB
      0.058   13.6   0.1       0.12   12.5   0.1    1.6  1  B-block_TFIIIC  B-block binding subunit of TFIIIC


Domain annotation for each model (and alignments):
>> E2F_CC-MB  E2F transcription factor CC-MB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.4   0.2   7.1e-34   3.2e-30       2      94 ..     147     245 ..     146     246 .. 0.96

  Alignments for each domain:
  == domain 1  score: 104.4 bits;  conditional E-value: 7.1e-34
   E2F_CC-MB   2 kqelesleeeeqkLDelieklteqlknltedeknq.laYvtyedirsiasfkeqtviaikAppgtqlevpdpee.....ekryqiyLkStsgpievylv 94 
                 ++e++++e +e+++D+li +++e+l+ l+e+e+n+ la+vty+d+  i+++k++tviaikAp+gt+l vpdp+e     ++ryqi+LkS  +pi+vylv
  EFC36120.1 147 QNEIAQIEYQERQVDQLIYHVQESLRCLNESEQNRrLAFVTYDDVLDISTLKDRTVIAIKAPSGTTLTVPDPDEgmemgKRRYQIFLKSPAEPIDVYLV 245
                 89**************************99999955************************************9778899*******************9 PP

>> E2F_TDP  E2F/DP family winged-helix DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.8   0.1   8.2e-29   3.7e-25       2      71 .]      66     129 ..      65     129 .. 0.98

  Alignments for each domain:
  == domain 1  score: 87.8 bits;  conditional E-value: 8.2e-29
     E2F_TDP   2 dksLgvltkkfvellkesakgtlslneaakeLvdkkdekvkkRRiYDilNVLealglieKeskneikWig 71 
                 d+sL++lt+kf++l++++++g+l+ln+aa++L       v+kRRiYDi+NVLe++glieK+skn+i+W+g
  EFC36120.1  66 DSSLRLLTRKFIHLIADAKDGVLDLNHAAETLS------VQKRRIYDITNVLEGIGLIEKKSKNNIQWLG 129
                 79*******************************......*****************************98 PP

>> TrmB  Sugar-specific transcriptional regulator TrmB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.2e-05     0.056      23      58 ..      88     123 ..      76     131 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.2e-05
                 CHHCHHCCCTTSSCHCHHHHHHHHHHCTSEEEESST CS
        TrmB  23 atadeiaeelgvprskvYevLrsLedkGlVerekgr 58 
                 ++ +  ae l v + ++Y++ + Le  Gl+e++ ++
  EFC36120.1  88 LDLNHAAETLSVQKRRIYDITNVLEGIGLIEKKSKN 123
                 55666799***********************98765 PP

>> B-block_TFIIIC  B-block binding subunit of TFIIIC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   2.7e-05      0.12      26      55 ..      95     134 ..      72     166 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.7e-05
  B-block_TFIIIC  26 keskqdprslfyrlksLekkgLIvkqsii..........d 55 
                      ++   +r ++ ++++Le +gLI+k+s +           
      EFC36120.1  95 ETLSVQKRRIYDITNVLEGIGLIEKKSKNniqwlgtgiaV 134
                     4445889*******************98755555555551 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1666  (0.0929221); expected 358.6 (0.02)
Passed bias filter:                      685  (0.0382063); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 1834.02
//
Query:       EFC36121.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1684  (0.093926); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.22s 00:00:00.67 Elapsed: 00:00:00.38
# Mc/sec: 2633.84
//
Query:       EFC36122.1  [L=584]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.053   13.5   0.1       0.19   11.7   0.1    2.0  1  RHH_3     Ribbon-helix-helix domain


Domain annotation for each model (and alignments):
>> RHH_3  Ribbon-helix-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   1.1e-05      0.19      10      31 ..     427     448 ..     421     454 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.1e-05
       RHH_3  10 dpelaekLkaLSekTrIprSkl 31 
                 d+++ ekL+++S +T ++ S+l
  EFC36122.1 427 DEKQIEKLDDISSETQVEESEL 448
                 899*****************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (584 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1417  (0.079034); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.22s 00:00:00.67 Elapsed: 00:00:00.37
# Mc/sec: 4745.42
//
Query:       EFC36123.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-06   26.8   3.1      9e-06   25.7   3.1    1.5  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   3.1     5e-10     9e-06      11      33 ..       3      25 ..       3      32 .. 0.89

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 5e-10
                ---STSSSS-HHHHHCTHHHCCC CS
     Zn_clus 11 vKCdakkPaCsnCkklnleCtfy 33
                +KCd+ +PaCs+Ck+++++C+++
  EFC36123.1  3 IKCDKLIPACSRCKQKGFKCEYN 25
                7********************54 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1109  (0.0618551); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.45
# Mc/sec: 3456.80
//
Query:       EFC36124.1  [L=107]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-14   52.1   0.1    5.7e-14   51.9   0.1    1.1  1  DUF2368   Uncharacterised conserved protein (DUF2368)


Domain annotation for each model (and alignments):
>> DUF2368  Uncharacterised conserved protein (DUF2368)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.9   0.1   3.2e-18   5.7e-14      38     118 ..      18     100 ..       6     104 .. 0.88

  Alignments for each domain:
  == domain 1  score: 51.9 bits;  conditional E-value: 3.2e-18
     DUF2368  38 mrerqmAlqiakarellkwlasfyalavvllaagaikrknpllliPlvPLtfvlaY...qydlaYGdklerireeAerileees 118
                 ++e  +A+++ak+re ++w +   ++ ++++++ +   k+  ++  l+P++ v++Y   +ydl YG+kl+r+ +eA++i ++e+
  EFC36124.1  18 ANEMTLAMNVAKSRERCRWAGGYLSVLTIGSMGYWALAKK-FPVGALIPISAVATYalwEYDLGYGNKLHRMGQEAQQIQTKER 100
                 456789************************9999999986.89999999999998855579*****************988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (107 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       339  (0.0189079); expected 358.6 (0.02)
Passed bias filter:                      257  (0.0143343); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.24s 00:00:00.64 Elapsed: 00:00:00.42
# Mc/sec: 760.43
//
Query:       EFC36125.1  [L=1665]
Description: diaphanous-related formin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.7e-58  196.4  18.2    5.6e-42  144.2  12.1    4.7  4  FH2       Formin Homology 2 Domain
    1.9e-17   63.5   7.9    1.9e-17   63.5   7.9    4.5  5  Drf_FH3   Diaphanous FH3 Domain
  ------ inclusion threshold ------
        1.1    9.9   9.2        6.2    7.5   0.7    4.3  3  SlyX      SlyX


Domain annotation for each model (and alignments):
>> FH2  Formin Homology 2 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   3.5      0.19   1.2e+03     305     345 ..     920     960 ..     882     977 .. 0.63
   2 ?    0.5   2.9     0.042   2.5e+02     268     328 ..     989    1046 ..     985    1063 .. 0.78
   3 !   65.8   0.3   6.4e-22   3.8e-18       4     149 ..    1158    1299 ..    1155    1301 .. 0.92
   4 !  144.2  12.1   9.3e-46   5.6e-42     171     371 ..    1300    1500 ..    1298    1501 .. 0.97

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.19
                 TSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         FH2 305 keepsdkflevlkeflkeaeeklkkleeelkeakelvkelv 345
                 +++++   ++ l+  ++++++++++l+++ ++ k +++e +
  EFC36125.1 920 EKQKQTSKISNLNLTIEKTNKEIDELKKQVENWKVKFNEST 960
                 33355555566666777777777777777777666666544 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.042
                  TTHHHCCTS-HHHHHHHHHHHHHHHHHHHHHHHHCCTTSSTT-THHHHHHHHHHHHHHHHH CS
         FH2  268 knvkkaakvnleslekevkklekglkklekelessekkeepsdkflevlkeflkeaeeklk 328 
                  + v+++  ++ + ++ke+++l+  +k+ e+++e+ +k   ++dk++++lke l+e ee  +
  EFC36125.1  989 EPVQQIIPIDTQIFTKEIDELKLLVKEKEDSVENVNK---ENDKLKDQLKELLMELEEHRR 1046
                  5678888889999999999999999999999999999...999999999999998887654 PP

  == domain 3  score: 65.8 bits;  conditional E-value: 6.4e-22
                  X---SS-B------EESSGGCTTSCCCC..TCCHHHHCTSHHHHHHHHTBSC--HCCH......HCSCCTTCCESSS-HHHHHHHHHHHHHHTS-HH CS
         FH2    4 kikpkkkLkplhWdkvkpsqdrstvWdk..lkeesfekeldlseleelFsakekkkkkkksekskkskkkkkkvklLdpkrsqniaIlLkklkltae 98  
                  k  pk   k ++  +++++++++t W k  + +es e ++d +ele+lFs + kk++k       ++kk+k+ +++ +p++  +++IlL  ++l++ 
  EFC36125.1 1158 KRAPKSAVKNFYGVAINRHKVSQTCWVKggIAAESKEVQIDEDELEDLFSNAPKKNNK------DEEKKRKELISFVEPQKGSALSILLGYIRLDYS 1248
                  67899999****************99873366677777**************998554......5799***************************** PP

                  HHHHHHHTTTTCCCTHHHHHHHHHHCGGHHHHHHHHCTCTSGTTB-HHHHH CS
         FH2   99 eiveaileldeealdlellenLlkmaPtkeelkklkeykgevseLseaeqF 149 
                  ei++aile+dee+l+++++++L + ++t +el+++++y+g+++ Ls+ ++F
  EFC36125.1 1249 EIKRAILEMDEEVLTAQVVDTLKDKMATADELSQIEAYNGDADLLSPVDKF 1299
                  *************************************************99 PP

  == domain 4  score: 144.2 bits;  conditional E-value: 9.3e-46
                  THHHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHSTCSTT.CS-SEE-GGGGGGCCCSB-STTTSBHHHHHHHHHHTTSGGGGGHHHH CS
         FH2  171 tfeeeveelkrslealeaaseeLknskkfkklLeliLalGNymNdgtrr.gqAkGFkLssLlkLsdvKstdnkttLLHylvkiireklpevldfsse 266 
                  +f++ev+e+ ++le++ +as+++ +s  fk+lL +iLa+ N++N++++  ++A+GF L+sL kL+d+K +dnk +LL y+ +++++ +p++l+ +++
  EFC36125.1 1300 KFQTEVSEVLSDLETVLTASTQVVQSSRFKRLLAVILAIANFLNANSSSkKNAYGFTLNSLSKLQDTKTSDNKSSLLQYISSYCEKSFPDLLNIKED 1396
                  8********************************************99877*********************************************** PP

                  TTTHHHCCTS-HHHHHHHHHHHHHHHHHHHHHHHHCCTTSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT--TT..CCHHHHHH CS
         FH2  267 LknvkkaakvnleslekevkklekglkklekelessekkeepsdkflevlkeflkeaeeklkkleeelkeakelvkelveYfgedkk..evspeeff 361 
                  ++++++a++v+l + ++e +kl++g++ +e+el++ +    +s +f+  ++ef+++a++ l+++ + l+++ e++k+++e f ed+k    +p+e+f
  EFC36125.1 1397 FSSLEDATRVSLVESDNEYRKLKQGFETMERELQNPQW---ESTTFKNNMSEFMESATRFLDDIDSILSKIDEKLKQIAEDFAEDEKtvCKNPNELF 1490
                  ***********************************999...9****************************************9999977789***** PP

                  HHHHHHHHHH CS
         FH2  362 kilreFlkef 371 
                  ++l++Fl++f
  EFC36125.1 1491 QTLNNFLNNF 1500
                  ********99 PP

>> Drf_FH3  Diaphanous FH3 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.5   7.9   3.2e-21   1.9e-17       5     176 ..     705     899 ..     701     925 .. 0.83
   2 ?   -1.6   0.2      0.29   1.8e+03      96     136 ..     935     975 ..     916     977 .. 0.76
   3 ?    1.0   2.2     0.047   2.8e+02      83     127 ..    1023    1074 ..    1005    1088 .. 0.65
   4 ?   -2.5   2.0      0.53   3.2e+03      86     182 ..    1373    1475 ..    1356    1490 .. 0.52
   5 ?   -2.0   0.6      0.38   2.3e+03     112     127 ..    1478    1493 ..    1444    1527 .. 0.56

  Alignments for each domain:
  == domain 1  score: 63.5 bits;  conditional E-value: 3.2e-21
                 HHHHHHHHHHHCCT-SSTTHHHHHHHHH.HSS-HHHHHHHHHHHHHHHHSSSSHHHHHHHHHHHHCTTHHHHHHHHCTS......CSHHHHHHHHHHHH CS
     Drf_FH3   5 kvleatldfkevaeergrfrslvgaldelenelveykvatmllInalvnspedlqfRlhLRseflalGLdkiidklrel......eneeLddqlqafee 97 
                  vle + ++k +++e++rfr l++ l+   +++ ++k+ ++ l+n l+n+p+d   R+ +R+e+++lGL+ ++dkl++       ++e+L++q+++fee
  EFC36125.1 705 TVLEGLNRYKTEKKEPRRFRDLIEFLK--VEKDEKLKTFCLMLLNSLINTPQDSFIRILIRNELKQLGLETVVDKLSNDlqhdriRDENLKEQIKVFEE 801
                 69999**********************..59999******************************************997789999************** PP

                 HHHHHHHHHH........HHHT......XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.........XXXXXXXXXXXXXXXXXXXXXXXX CS
     Drf_FH3  98 erneDeeell........erae......dktvdlddpeelfellknkvkdteaepyllsilqhllli.......rddeeekesylklleelvsqivlqr 175
                 e      e          e  +      ++    +dp ++++ll  ++ +t+   +l+silq+ll          + e ++  ++k l+++++ +v   
  EFC36125.1 802 EMMIGLIEKEqagvsddsE--NttenlfKNFKSETDPLKIVKLLILRLGATTGTSHLVSILQNLLSYsmsssmdPKFEPQLLTSWKNLDNTIKSMVQAC 898
                 **97666666666665440..15555653444445789***************************9988885444444455667888888888777655 PP

                 X CS
     Drf_FH3 176 t 176
                 +
  EFC36125.1 899 Q 899
                 5 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.29
                 HHHHHHHHHHHHHHHTXXXXXXXXXXXXXXXXXXXXXXXXX CS
     Drf_FH3  96 eeerneDeeelleraedktvdlddpeelfellknkvkdtea 136
                  e+ n+  +el++++e+ +v++++ ++  + l+n++ + +a
  EFC36125.1 935 IEKTNKEIDELKKQVENWKVKFNESTKNISILSNQLNNLQA 975
                 55666777888888888888888888888888888777665 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.047
                  S..CSHHHHHHHHHHHHHHHH.HHHHHHHHHT....XXXXXXXXXXXXXXXX CS
     Drf_FH3   83 l..eneeLddqlqafeeerne.Deeellerae....dktvdlddpeelfell 127 
                  +  en++L+dql+  ++e +e    +++++++    +++ + +++++++e  
  EFC36125.1 1023 VnkENDKLKDQLKELLMELEEhRRMSFKQSLQtttgTVRSNSSNTSSISEVS 1074
                  4559*********999887631444555555555555555555555554443 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 0.53
                  HHHHHHHHHHHHHHHHHHHHHHHHHT....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXX CS
     Drf_FH3   86 eeLddqlqafeeerneDeeellerae....dktvdlddpeelfellknkvkdteaepyllsilqhllli..rddeeekesylklleelvsqivlqrt 176 
                  + L + +  + e+ + D    +e++     + +v l + ++ + +lk+ ++++e e +        + +  ++ +e+ +++l  +++++s+i+ + +
  EFC36125.1 1373 SSLLQYISSYCEKSFPDLLNIKEDFSsledATRVSLVESDNEYRKLKQGFETMERELQNPQWESTTFKNnmSEFMESATRFLDDIDSILSKIDEKLK 1469
                  5555555566666666655555555555555555555555555555555555555544322222222223345555566666666666666666666 PP

                  XXXXXX CS
     Drf_FH3  177 kidpkk 182 
                  +i +++
  EFC36125.1 1470 QIAEDF 1475
                  666655 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 0.38
                  XXXXXXXXXXXXXXXX CS
     Drf_FH3  112 dktvdlddpeelfell 127 
                  d++   ++p+elf+ l
  EFC36125.1 1478 DEKTVCKNPNELFQTL 1493
                  3333333333333333 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.2   1.3e+04      19      33 ..     577     591 ..     575     604 .. 0.73
   2 ?    7.5   0.7     0.001       6.2      15      50 ..     924     959 ..     922     983 .. 0.86
   3 ?    3.7   1.5     0.016        96      17      53 ..    1004    1040 ..     997    1048 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.2
                 HHHHHHHHHHHHHHH CS
        SlyX  19 ieeLndvvaeqqqqi 33 
                 i++L d+v++q+   
  EFC36125.1 577 IKKLKDQVTNQHPSA 591
                 788999999997655 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.001
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXX CS
        SlyX  15 qedtieeLndvvaeqqqqidrlqrqlrllaerlkel 50 
                 q   i  Ln ++ + +++id+l++q++  + +++e 
  EFC36125.1 924 QTSKISNLNLTIEKTNKEIDELKKQVENWKVKFNES 959
                 6678999*******************9988888654 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.016
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXX CS
        SlyX   17 dtieeLndvvaeqqqqidrlqrqlrllaerlkelees 53  
                  + i+eL   v e ++ ++   ++ ++l+++lkel  +
  EFC36125.1 1004 KEIDELKLLVKEKEDSVENVNKENDKLKDQLKELLME 1040
                  6799999************************998655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3343  (0.186458); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                       113  (0.00630264); expected 17.9 (0.001)
Passed Fwd filter:                        50  (0.00278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.91u 0.38s 00:00:02.29 Elapsed: 00:00:00.62
# Mc/sec: 8139.55
//
Query:       EFC36126.1  [L=204]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.2e-08   34.4   0.0    2.7e-08   34.1   0.0    1.2  1  Lipocalin    Lipocalin / cytosolic fatty-acid binding protein
    7.7e-05   22.6   0.3    0.00012   22.0   0.3    1.4  1  Lipocalin_2  Lipocalin-like domain
  ------ inclusion threshold ------
       0.11   12.4   0.1       0.14   12.0   0.1    1.2  1  Triabin      Triabin


Domain annotation for each model (and alignments):
>> Lipocalin  Lipocalin / cytosolic fatty-acid binding protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.1   0.0   4.6e-12   2.7e-08       2     134 ..      48     187 ..      47     197 .. 0.78

  Alignments for each domain:
  == domain 1  score: 34.1 bits;  conditional E-value: 4.6e-12
                 EEEEEEEEEESSGGHHSTTHTTTEEEEEEEEE.TTTEEEEEEEEEETTE..EEEEEEEEEEESSTTEEEEEEEE...STTEE......EEEEEEEESSS CS
   Lipocalin   2 GkWyliasandnsefeeeekklrvyiaeikpt.eegnlevteiekdggk..ceeesitakkteepgklgvefde...yldgr......kvkvlttdydn 88 
                 G Wy++a         ++++++ +   ++++  +++ l++ e++ +gg+    + +    + ++p+k+ v ++       +       +++v++tdy +
  EFC36126.1  48 GLWYQVATY------RTFLERGVCASINVTLSsDGSMLNIAESHYRGGRkdYFNLT-ASPNATTPAKMIVSYQVpqrR--DQfetvqfPIQVVDTDYIS 137
                 779999998......7****************999999**********94544444.445679*******99888652..22357778*********** PP

                 EEEEEEEEEET.TE.EEEEEEEEESSSSEEHHH..HHHHHHHHHHTTETG CS
   Lipocalin  89 ylilylkkeke.gk.ttlvaellsrdpelspel..leefkkflkelgide 134
                 yl+++++ +++    ++++a+l+ r+++    +   +++ + l++ g+  
  EFC36126.1 138 YLLVWSCENSRtALySNEMAWLYVRTLDEASHYqmRTKVWDRLEDFGMRR 187
                 *********888999***********987654322555555555555555 PP

>> Lipocalin_2  Lipocalin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.3     2e-08   0.00012       3     129 ..      43     174 ..      41     195 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 2e-08
  Lipocalin_2   3 lerYlGkWyeiArlpmrfergcvdvtaeYtlrddgtiaVenrcrevegklkeiegkAkvedeaseaklkVsFlkeflrievvkgdYwvleldddy.sl 99 
                  ++   G Wy++A + +++erg  ++ +  tl  dg++    +     g+ +  + +A++++++  ak+ Vs++++  r ++ + ++ +  +d dy s+
   EFC36126.1  43 VSSLVGLWYQVATYRTFLERGVCASIN-VTLSSDGSMLNIAESHYRGGRKDYFNLTASPNATT-PAKMIVSYQVPQRRDQFETVQFPIQVVDTDYiSY 138
                  67778**************99887665.58899997766666666899999999999999966.**********888899999999999999997356 PP

  Lipocalin_2 100 alvgsp........srkylwilsRtpqlseeqleklle 129
                   lv s         s++ +w++ Rt +  e+   ++++
   EFC36126.1 139 LLVWSCensrtalySNEMAWLYVRTLD--EASHYQMRT 174
                  666544111111113355688888766..444444444 PP

>> Triabin  Triabin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   2.4e-05      0.14      39     123 ..      59     148 ..      30     159 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.4e-05
                 ---SEEEEEEE-SSS.---EEEE.EES-T...TS-TT-EEEEEE-S--TT-EEEEEEETT-..--EEEEEEEEEE-TTSEEEEEEEEEES CS
     Triabin  39 vtkpkvCqkykttkn.kGtttilseikfnG..ksesevkctlakvegkkGqysfeCevsdg..kkftaelsviatdYknyALlyrcgkfe 123
                   +  vC   ++t + +G    ++e ++ G  k   +++   +    +k   s++     +   +++  + v++tdY  y L+ +c +  
  EFC36126.1  59 FLERGVCASINVTLSsDGSMLNIAESHYRGgrKDYFNLTASPNATTPAKMIVSYQVPQRRDqfETVQFPIQVVDTDYISYLLVWSCENSR 148
                 45567999999887669998888888888733444566666666666666666665554434567777899***************8765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (204 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       757  (0.0422221); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1383.26
//
Query:       EFC36127.1  [L=1469]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.05   13.7   0.1       0.05   13.7   0.1    3.7  4  Dynamin_N  Dynamin family


Domain annotation for each model (and alignments):
>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.7      0.12   2.2e+03      53      87 ..     501     535 ..     470     565 .. 0.70
   2 ?   13.7   0.1   2.8e-06      0.05       1      35 [.     613     646 ..     613     686 .. 0.82
   3 ?   -0.4   0.6     0.058     1e+03      50      94 ..     948     993 ..     932    1070 .. 0.73
   4 ?   -2.9   0.1      0.34   6.1e+03      59      98 ..    1269    1308 ..    1235    1313 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.12
                 SSEEEET-EB--CHHHHHHHHHHHHHHHTSSSS-- CS
   Dynamin_N  53 eelkekekkledfsevreeieketekiagankgis 87 
                  +++ +e + +d+++ + e+e+e++k+++++++ s
  EFC36127.1 501 SNQQPNEPQAKDLEKKKSELEQEKKKLERKMQSES 535
                 33333366677777777777777777776666655 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2.8e-06
                 EEEEEBTTTTHHHHHHHHHTS--S---SSS---S- CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlgedilprgpnptTrrp 35 
                 + ++G+qSs KS+v+n+L  ++ + +g++ +Tr +
  EFC36127.1 613 VSILGHQSSYKSTVMNSLFNSQ-FSMGQGKCTRGV 646
                 6789******************.799******965 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.058
                 ...SSEEEE.T-EB--CHHHHHHHHHHHHHHHTSSSS--SS-EEEE CS
   Dynamin_N  50 avkeelkek.ekkledfsevreeieketekiagankgiskkvillk 94 
                 +v + +k+  ++  + +++v+++i++e + +++  ++  ++ i+++
  EFC36127.1 948 KVVQAFKNTtNQVGDAIQQVNRKIKEEYQLLKQMSEKEREERINTY 993
                 4444455555666677777777777777777765555555544443 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 0.34
                  T-EB--CHHHHHHHHHHHHHHHTSSSS--SS-EEEEEEET CS
   Dynamin_N   59 ekkledfsevreeieketekiagankgiskkvillkilsl 98  
                  +++ ++++++ e+i+++++  + an g   +vil+k++s 
  EFC36127.1 1269 NSEPSNAQDLYEKIKQQSSSTKYANLGSEFTVILFKDCST 1308
                  5666777788888888777777777777777888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1469 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2041  (0.113838); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.09u 0.35s 00:00:01.44 Elapsed: 00:00:00.52
# Mc/sec: 8576.31
//
Query:       EFC36128.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.1e-18   64.8   1.1    7.1e-18   64.8   1.1    2.2  2  SAM_1     SAM domain (Sterile alpha motif)
    1.4e-15   57.1   0.5    4.7e-15   55.4   0.5    2.0  1  SAM_2     SAM domain (Sterile alpha motif)
    1.3e-09   37.9   0.5    3.6e-09   36.4   0.5    1.8  1  PB1       PB1 domain
  ------ inclusion threshold ------
      0.013   15.3   0.1      0.048   13.5   0.1    1.9  1  SAM_3     SAM domain (Sterile alpha motif)
      0.043   13.8   1.2      0.059   13.4   0.1    1.8  2  SAM_PNT   Sterile alpha motif (SAM)/Pointed domain


Domain annotation for each model (and alignments):
>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1         3   1.1e+04      38      49 ..      17      28 ..      15      35 .. 0.77
   2 !   64.8   1.1     2e-21   7.1e-18       3      61 ..      38      97 ..      37      99 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3
                CHHHHHHCTTTS CS
       SAM_1 38 teddLeklgvtl 49
                t dd ek+++++
  EFC36128.1 17 TTDDDEKIKIRK 28
                789999999966 PP

  == domain 2  score: 64.8 bits;  conditional E-value: 2e-21
                TTHSSHHHHHHHTTSGGGHHHHHTTTSSHHHHTTSCHHHHHH.CTTTSHHHHHHHHHHHH CS
       SAM_1  3 wsvedVgeWLesiglgqYadlFrageidgdaLlllteddLek.lgvtllGHrkkIlyaIq 61
                ws +dV+ WL+si+l++Y+++F++  i+g  Ll+lt+ddL k l++++lGHrk++ + ++
  EFC36128.1 38 WSAKDVSLWLKSIDLQDYCKEFEKMDITGAELLELTDDDLVKdLKISKLGHRKRLKKQLD 97
                9******************************************************98775 PP

>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.4   0.5   1.3e-18   4.7e-15       4      65 ..      38      99 ..      37     100 .. 0.94

  Alignments for each domain:
  == domain 1  score: 55.4 bits;  conditional E-value: 1.3e-18
                HHHHHHHHHHHHTTTGGGHHHHHHTTCSHHHHHTTSCHHHH.HHTTHHHHHHHHHHHHHHHHH CS
       SAM_2  4 wsledvaeWLrsiglkqytdnFrdagitgaelllrlteedL.krlGitsvghrkkilkkiqel 65
                ws++dv+ WL+si+l++y++ F++  itg   ll+lt +dL k+l+i+++ghrk++ k+++ l
  EFC36128.1 38 WSAKDVSLWLKSIDLQDYCKEFEKMDITG-AELLELTDDDLvKDLKISKLGHRKRLKKQLDYL 99
                9****************************.8888*******66*************9998766 PP

>> PB1  PB1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.4   0.5     1e-12   3.6e-09      16      82 ..     189     257 ..     170     259 .. 0.85

  Alignments for each domain:
  == domain 1  score: 36.4 bits;  conditional E-value: 1e-12
                 EEEGSSS-HHHHHHHHHHHHTST..CCSEEEEEEETTSSEEEESSHHHHHHHHHHHHHTSSCCEEEEEE CS
         PB1  16 lsvssnisfeeLrakvekrfkls..dedvklkYpdedgdlVtitsDeDLeealeearslksktlrlhvq 82 
                 +s + +++++++  +v +r ++   +++++lkY+ded d +t++ ++D++ +l  +r+++++ l+l++ 
  EFC36128.1 189 FSPEDELTLQKVKMEVLSRKPILssTNQIQLKYKDEDDDIITLKKEDDFKLCLANYRNSGQRYLKLYIS 257
                 4555567999999999999999999*********************************9999***9985 PP

>> SAM_3  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   1.3e-05     0.048      11      50 ..      39      79 ..      38      83 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.3e-05
       SAM_3 11 tpeeVkaWLtakgFskktvesLgkl..sGaqLfsLskeeLeq 50
                ++++V  WL+  ++ ++ ++ ++k+  +Ga+L++L+ ++L++
  EFC36128.1 39 SAKDVSLWLKSIDLQDY-CKEFEKMdiTGAELLELTDDDLVK 79
                578*************5.****986338**********9976 PP

>> SAM_PNT  Sterile alpha motif (SAM)/Pointed domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   1.6e-05     0.059      16      66 ..      34      82 ..      17     101 .. 0.80
   2 ?   -3.4   0.1       2.8     1e+04      29      61 ..     315     347 ..     312     352 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.6e-05
                SGGG--HHHHHHHHHHHHHHTT-SS-HGGGCTS-HHHHHHS-HHHHHHHSC CS
     SAM_PNT 16 dPqeWtkehVlewlewavkefdlakidfsefdmsGkeLcsltkeefleaap 66
                   +W+ ++V  wl+     ++  + +f+++d+ G+eL++lt  ++ + ++
  EFC36128.1 34 AICDWSAKDVSLWLKSID--LQDYCKEFEKMDITGAELLELTDDDLVKDLK 82
                5568*********98542..3334669*****************9988765 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.8
                 HHHHHHHTT-SS-HGGGCTS-HHHHHHS-HHHH CS
     SAM_PNT  29 lewavkefdlakidfsefdmsGkeLcsltkeef 61 
                 ++wa k  + +k++ ++ + s k+ c + k+ f
  EFC36128.1 315 VSWAKKCAKYKKVKYCKERKSVKKCCLIKKKFF 347
                 678888777788877776666666666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1228  (0.0684924); expected 358.6 (0.02)
Passed bias filter:                      235  (0.0131073); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2701.59
//
Query:       EFC36129.1  [L=474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0064   16.6   1.1     0.0064   16.6   1.1    3.4  3  HR1             Hr1 repeat
     0.0087   15.8   0.3     0.0087   15.8   0.3    3.9  4  DivIC           Septum formation initiator
  ------ inclusion threshold ------
      0.075   13.2   0.4       0.21   11.7   0.4    1.7  1  Caenor_Her-1    Caenorhabditis elegans Her-1
       0.14   12.2   2.1       0.47   10.5   2.1    1.9  1  Cnd1            non-SMC mitotic condensation complex subunit 
       0.28   11.8   8.4       0.47   11.0   0.2    3.7  3  LsmAD           LsmAD domain
        6.5    7.5  17.0         17    6.1   0.5    4.3  3  SlyX            SlyX


Domain annotation for each model (and alignments):
>> HR1  Hr1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   1.1   2.1e-06    0.0064      35      67 ..     202     234 ..     174     236 .. 0.88
   2 ?   -2.8   0.0       2.4   7.3e+03      47      62 ..     313     328 ..     309     333 .. 0.75
   3 ?   -3.4   7.7       3.6   1.1e+04       4      60 ..     401     454 ..     381     461 .. 0.71

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 2.1e-06
         HR1  35 kvrqeaeselsesnskielLreqLeelqasvqn 67 
                 k++++  +el++ ++ki++L+ ++++l++++  
  EFC36129.1 202 KYIEKLSQELDKKKRKIKELTLEIKKLNQMHIS 234
                 699**************************9986 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.4
         HR1  47 snskielLreqLeelq 62 
                  ++++++L+ q++  +
  EFC36129.1 313 RDREVKELEAQIKSWK 328
                 5678888998888766 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 3.6
         HR1   4 elekklekElkireGAenllralesk.ktqnkkvrqeaeselsesnskielLreqLee 60 
                 +l+ +l+ E+   +  e l+     k +++  +++ +   else +++++ Lr+ L+ 
  EFC36129.1 401 KLQTELRNEKSSGNELEDLVV----KqQKNFSDYQDKTSRELSECRKELDRLRRILKM 454
                 455555555555555555555....213333449999999999999999999988765 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.3   2.9e-06    0.0087      25      72 ..     203     253 ..     200     258 .. 0.92
   2 !    8.1   0.3   0.00076       2.3      22      50 ..     313     341 ..     309     348 .. 0.84
   3 ?   -3.8   0.2       3.8   1.1e+04      39      52 ..     355     368 ..     349     374 .. 0.57
   4 ?   -2.0   1.9       1.1   3.2e+03      29      29 ..     431     431 ..     398     465 .. 0.53

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.9e-06
                 HHHHHHHHHHHHHHHHHHHHHHHCC-XX...XXXXXXXXXXXXXXXXXXXX CS
       DivIC  25 eiaalqaelaklkaeneeLeaevkdLks...dedyieerARselglvkpgE 72 
                  i++l +el+k+k +++eL+ e+k+L++   + d  ++  R + g+ ++gE
  EFC36129.1 203 YIEKLSQELDKKKRKIKELTLEIKKLNQmhiSNDIDQKLIRFRSGMNMNGE 253
                 6999**********************77**9999999********999999 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00076
                 HHHHHHHHHHHHHHHHHHHHHHHHHHCC- CS
       DivIC  22 lkqeiaalqaelaklkaeneeLeaevkdL 50 
                  ++e+++l+a++++ k++ ++L++e+   
  EFC36129.1 313 RDREVKELEAQIKSWKDTADKLKDELTST 341
                 68899999999999999999999998765 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 3.8
                 HHHHHHHHHCC-XX CS
       DivIC  39 eneeLeaevkdLks 52 
                 e  +L +e+++ +s
  EFC36129.1 355 EASKLLKEIQRANS 368
                 44455566666544 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.1
                 H CS
       DivIC  29 l 29 
                 +
  EFC36129.1 431 Q 431
                 1 PP

>> Caenor_Her-1  Caenorhabditis elegans Her-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.4     7e-05      0.21      14      82 ..     378     446 ..     368     462 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7e-05
                   HHHT----TT--S-TTHHHHHHHHHHHHHTSS-GGG---GGGGGGGGG.GGCTTTCCCHHHHHHHHHHCT CS
  Caenor_Her-1  14 ikfglplrCgyekekklpklvykClqkelfaeeeekrlelddsvCCqv.fkkdqndpkrrCekiCktvle 82 
                   + f + l  +ye+e+k + ++ + lq+el +e+ +   el+d+v  q    +d +d+ +r  ++C+  l+
    EFC36129.1 378 VIFYKNLASHYESENKKNLVMNEKLQTELRNEKSSG-NELEDLVVKQQkNFSDYQDKTSRELSECRKELD 446
                   568899999********************9887776.89***9987641568999**********98775 PP

>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   2.1   0.00016      0.47      89     151 ..     352     412 ..     322     424 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00016
        Cnd1  89 senaiynllpdiisklsdalnecsewgqitilefLlsyipkdkqeaeslveklcprlqhansa 151
                 +en++ +ll++i    s   ++++e++ +  ++ L+s+ +++++++  + ekl  +l++++s+
  EFC36129.1 352 AENEASKLLKEIQRANS--SQNFEEETKVIFYKNLASHYESENKKNLVMNEKLQTELRNEKSS 412
                 44555555555544433..568**********************999999*******999876 PP

>> LsmAD  LsmAD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.2   0.00016      0.47       8      54 ..     196     240 ..     192     257 .. 0.85
   2 ?   -2.0   0.1       1.8   5.4e+03      22      40 ..     323     341 ..     309     354 .. 0.57
   3 ?    3.1   1.0     0.046   1.4e+02      26      52 ..     352     377 ..     343     394 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00016
       LsmAD   8 dEnlYTtkldksspeykereaeAeriArEIessastnahvaeerglk 54 
                 +E lYT  ++k s+e  ++ ++ + +  EI++   +++h++++ ++k
  EFC36129.1 196 KERLYTKYIEKLSQELDKKKRKIKELTLEIKKL--NQMHISNDIDQK 240
                 699***************************987..567888887775 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.8
       LsmAD  22 eykereaeAeriArEIess 40 
                 + k     A+++  E++s+
  EFC36129.1 323 QIKSWKDTADKLKDELTST 341
                 3333344455555555554 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.046
       LsmAD  26 reaeAeriArEIessastnahvaeerg 52 
                  e+eA+++ +EI++ +s+ +  +ee +
  EFC36129.1 352 AENEASKLLKEIQRANSS-QNFEEETK 377
                 5789*********99554.44555554 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.5    0.0056        17      17      45 ..     202     230 ..     199     241 .. 0.87
   2 ?    4.6   1.7     0.017        50       4      60 ..     316     373 ..     314     377 .. 0.75
   3 ?    3.5   1.6     0.037   1.1e+02       8      40 ..     402     434 ..     399     468 .. 0.65

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0056
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        SlyX  17 dtieeLndvvaeqqqqidrlqrqlrllae 45 
                 + ie+L++++ +  ++i++l+ ++++l++
  EFC36129.1 202 KYIEKLSQELDKKKRKIKELTLEIKKLNQ 230
                 56999999999999999999999999987 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.017
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-.XXXXXXXXXXXXX CS
        SlyX   4 rleeLEiklafqedtieeLndvvaeqqqqidrlqrqlrllaerl.keleessgaseae 60 
                  ++eLE ++    dt ++L d+++  + +  + +   +  a +l ke++ ++++++ e
  EFC36129.1 316 EVKELEAQIKSWKDTADKLKDELTSTRSEFVQYKISAENEASKLlKEIQRANSSQNFE 373
                 6889********************9999988887777666666646666665544444 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.037
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        SlyX   8 LEiklafqedtieeLndvvaeqqqqidrlqrql 40 
                 L+++l       +eL d v++qq+  +  q + 
  EFC36129.1 402 LQTELRNEKSSGNELEDLVVKQQKNFSDYQDKT 434
                 666666666666788888888888776555433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2458  (0.137096); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.81u 0.36s 00:00:01.17 Elapsed: 00:00:00.57
# Mc/sec: 2499.30
//
Query:       EFC36130.1  [L=393]
Description: hypothetical protein NAEGRDRAFT_44886 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
   9.6e-106  353.8   0.0   1.3e-104  350.1   0.0    1.9  1  Actin      Actin
  ------ inclusion threshold ------
        0.2   11.6   0.0       0.33   10.9   0.0    1.3  1  TetR_C_14  MftR C-terminal domain


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  350.1   0.0  1.4e-108  1.3e-104       2     404 ..       6     389 ..       5     392 .. 0.95

  Alignments for each domain:
  == domain 1  score: 350.1 bits;  conditional E-value: 1.4e-108
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.............klyvgdealtkrpelevrspvedG..vvedwdaveelwehvlk 85 
                 d+  a+V+D Gss+++aG age++Pkav+p+++gkp+ +  +               ++vg ea ++++  e+++p+++G   v++wd++e l+eh+++
  EFC36130.1   6 DHQGAIVCDLGSSFVKAGLAGEQFPKAVFPTIIGKPKSHVDTRklfgarekmneakSYFVGLEAHQRKGICELSHPINRGgkGVQNWDDIELLLEHIYH 104
                 7889********************************99865559***********9*******9999**********888455**************** PP

       Actin  86 eelkvdpeehpllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlk 184
                  +l+v+p++hp+llte+pl++ + r++ ++++fEkf+ ++l++a +  ls +a+g   g+v+DsG+++t+vvpV++Gy+ ++a+ +s+l+G ++t++l+
  EFC36130.1 105 FHLRVNPKDHPILLTEQPLTSVTHRQQYIQLLFEKFQSHSLFFAIQGLLSIYATGDLDGIVLDSGDGSTHVVPVFEGYPQTYAMLKSELAGCDITNHLT 203
                 *************************************************************************************************** PP

       Actin 185 ellssknvevtprylikkkkvveaessaekeelekltesyk.tleeeevleeiKesvcevsedpeg....deeksssspeksYeLPDgseiklgeeRfk 278
                 +l+ ++                              ++ ++ +++    ++++Ke+ c+v+ +  +     +e++++++++++ LPDg+ i++  eRf+
  EFC36130.1 204 KLMLQH-----------------------------SGYDFTqNSASLDFVRDVKEASCYVALNYDHtlklFQESKKNEFRNQFQLPDGTFINIDCERFQ 273
                 **9995.............................4677751567889***************99988887778889********************** PP

       Actin 279 vpEiLFdpsligsesaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSi 377
                 ++EiLF+p++igse+          gi+el+ ++i++c++d+r+++++n++++GGn+l++g++eRl +e+++++   v+++iiap+ erkys+WiGGSi
  EFC36130.1 274 AAEILFQPNMIGSEEL---------GIHELLNTSIQHCNMDIRKNMFKNVILSGGNTLIKGIQERLTREMTRMVGGAVRLRIIAPP-ERKYSVWIGGSI 362
                 *************988.........*************************************************************.************ PP

       Actin 378 LAslgtfqqlwvskqEYeEqGssvver 404
                 L+sl++fq+ w+ +++YeE G++++ +
  EFC36130.1 363 LSSLSSFQDRWIRRADYEELGPDLISK 389
                 ***********************9987 PP

>> TetR_C_14  MftR C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   3.7e-05      0.33      46      98 ..     331     384 ..     323     391 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 3.7e-05
                 HHHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHHHHHHH-TT.S-HHH CS
   TetR_C_14  46 yaawrevvAefvAeRtgtdaddlvprtvaaavlaaalaayeqwladed.adlae 98 
                 ++++ ++v  +v  R+ ++++  +  ++++ +l+   +  ++w++++d ++l  
  EFC36130.1 331 TREMTRMVGGAVRLRIIAPPERKYSVWIGGSILSSLSSFQDRWIRRADyEELGP 384
                 67899****************************************998777654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       472  (0.0263261); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.35s 00:00:01.02 Elapsed: 00:00:00.55
# Mc/sec: 2134.23
//
Query:       EFC36131.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.3e-37  128.7  20.5    2.3e-37  128.7  20.5    1.5  2  TRAM_LAG1_CLN8  TLC domain
  ------ inclusion threshold ------
      0.021   15.8   2.4       0.38   11.8   0.1    3.1  3  DUF4834         Domain of unknown function (DUF4834)
      0.072   13.3   6.0        2.4    8.4   0.0    3.3  3  HemY_N          HemY protein N-terminus
       0.25   11.5   2.1        1.1    9.4   0.9    2.3  2  GWT1            GWT1
          2    9.0   6.7         17    6.0   0.3    4.4  5  DUF3899         Domain of unknown function (DUF3899)


Domain annotation for each model (and alignments):
>> TRAM_LAG1_CLN8  TLC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.3       1.8   6.3e+03     134     150 ..      70      86 ..      63      97 .. 0.72
   2 !  128.7  20.5   6.3e-41   2.3e-37       2     197 ..     116     340 ..     115     341 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.8
  TRAM_LAG1_CLN8 134 fngllfllsFfvcRlvl 150
                     f+ +  +++F+v Rlv+
      EFC36131.1  70 FVLISAVIIFIVRRLVI 86 
                     33467778888888875 PP

  == domain 2  score: 128.7 bits;  conditional E-value: 6.3e-41
  TRAM_LAG1_CLN8   2 fdervvslvqyllstvfglivlsssp......elwegyperilgathfllkayyllalgYfiydllvlllyekkrkdfvemliHhiitlvllvls 90 
                     ++e+++ +++y++s+++g+ +l ++p      +l  gype+++g +  l++ y+l+++g++++ l+ l+++++k kdf+eml+Hh++t+ l++ +
      EFC36131.1 116 VQENTWFSLYYTISSIAGFLILQQTPwlfdlnHLIIGYPEQHTGFEYPLMREYLLVGAGFYVQALFTLIFVDEKMKDFWEMLVHHLVTIGLIYGC 210
                     799***********************888777777777*****9999************************************************ PP

  TRAM_LAG1_CLN8  91 yvrnlgrvglvvlllhelsdpflnlrkilsylkkkskssklvlfngllfllsFfvcRlvllpylillsildvaklslstap.............. 171
                     +  +++r+g++vl+lh+++d+fl+ +k  + +k   +s++  lf  +lf+l F+++Rl+++p lil+s  ++a ++ ++                
      EFC36131.1 211 ISVYYHRIGTLVLILHDVVDIFLYCAKASKHMKAR-ESTTTALF--VLFVLAFLLLRLIYFPSLILKSLTNYAGWDYPSRYylvryvsdsvtpie 302
                     ********************************666.788899**..***************************99999888************** PP

  TRAM_LAG1_CLN8 172 ............lwlpliflilllvLqllnlyWfyliv 197
                                 l  ++ +++l+++L +l+++Wf+li 
      EFC36131.1 303 vsdygiclqrycLSPYWALIALMAMLVCLHIFWFSLIS 340
                     ***********99999999999999***********96 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   0.00011      0.38       6      49 ..      70     113 ..      68     128 .. 0.68
   2 ?   -1.6   0.7       1.5   5.5e+03       3      17 ..     253     267 ..     250     282 .. 0.49
   3 ?    2.0   0.0      0.11   4.1e+02       5      35 ..     322     353 ..     320     375 .] 0.60

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00011
     DUF4834   6 filifiiailviglsilsvilrtvfglgsrkkssksaqkqfgns 49 
                 f+li  ++i+++   ++ +i+  +fgl ++++ +k +++  +++
  EFC36131.1  70 FVLISAVIIFIVRRLVIEKIVAHLFGLNKKSNDKKDEKEAAAKA 113
                 567777778888888999999999**998877764433333322 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.5
     DUF4834   3 fLlfilifiiailvi 17 
                 f+lf+l f+++ l+ 
  EFC36131.1 253 FVLFVLAFLLLRLIY 267
                 334443333333333 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.11
     DUF4834   5 lfilifiiailviglsilsv.ilrtvfglgsr 35 
                   ++ +++++ ++ +s++s+ + r++ g g  
  EFC36131.1 322 IALMAMLVCLHIFWFSLISKiVWRKLVGRGLD 353
                 55677888888888888887356888775543 PP

>> HemY_N  HemY protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.0   0.00067       2.4       6      59 ..      59     112 ..      57     121 .. 0.81
   2 ?    4.0   0.1     0.015        54      18      38 ..     250     267 ..     239     287 .. 0.57
   3 ?    1.8   0.7     0.077   2.8e+02      11      35 ..     312     336 ..     310     350 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00067
      HemY_N   6 awggyrietslvvavlllvllfvllylllrllrlllrlparvrrwrrrrrerka 59 
                 +  ++ ++ +  v++ ++++++v  +++++++++l++l ++++   +++   ++
  EFC36131.1  59 RRSNWLYQDTQFVLISAVIIFIVRRLVIEKIVAHLFGLNKKSNDKKDEKEAAAK 112
                 5678899999999*************************9999987555444433 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.015
      HemY_N  18 vavlllvllfvllylllrllr 38 
                 +   +l++lfvl++lllrl+ 
  EFC36131.1 250 T---ALFVLFVLAFLLLRLIY 267
                 3...44444555555555443 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.077
      HemY_N  11 rietslvvavlllvllfvllylllr 35 
                 r+ +s   a+++l++++v l++++ 
  EFC36131.1 312 RYCLSPYWALIALMAMLVCLHIFWF 336
                 6778888999999999999999984 PP

>> GWT1  GWT1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.18   6.5e+02     113     122 ..      99     108 ..      50     147 .. 0.52
   2 ?    9.4   0.9   0.00031       1.1       9     111 ..     207     363 ..     204     375 .] 0.66

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.18
        GWT1 113 eeekerkeka 122
                 +++++++ek+
  EFC36131.1  99 KSNDKKDEKE 108
                 1111111111 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00031
        GWT1   9 liGylaiyllgvslgkyvlkrekeaeeeekkkkkkkkesketlkllikllllsilllllllllelyvef...................v.......... 78 
                 + G++++y+  +++  ++l++   +     k +k+ k +++t+++l  l++l++lll l+++ +l ++                    +          
  EFC36131.1 207 IYGCISVYYHRIGTLVLILHDVVDIFLYCAKASKHMKARESTTTALFVLFVLAFLLLRLIYFPSLILKSltnyagwdypsryylvryvSdsvtpievsd 305
                 679999999999999999966666554446667778888888999999999999998888777777666666577766666666555505555555555 PP

        GWT1  79 ....SRrlaNlpYvlwvvalnltllllflliellfv.....................e 111
                       r +  pY  +++ + + ++l ++ ++l+                       +
  EFC36131.1 306 ygicLQRYCLSPYWALIALMAMLVCLHIFWFSLISKivwrklvgrglddireddvddS 363
                 5665899999999888887777777666655552224456777777777776666541 PP

>> DUF3899  Domain of unknown function (DUF3899)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.3    0.0048        17      43      81 ..      92     136 ..      70     138 .. 0.58
   2 ?   -0.7   0.0      0.57   2.1e+03      61      83 ..     161     183 ..     152     184 .. 0.77
   3 ?   -0.4   0.0      0.46   1.7e+03      64      79 ..     197     212 ..     185     216 .. 0.56
   4 ?   -0.9   0.1      0.67   2.4e+03      67      78 ..     252     263 ..     234     268 .. 0.51
   5 ?    1.9   0.0     0.089   3.2e+02      33      58 ..     336     372 ..     320     375 .] 0.52

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0048
     DUF3899  43 k....skkddsyyeykek..kkesskkstrplliiGlllivlsiv 81 
                 +    +kk+ ++ ++ke   k++++   t++ l++ + +i+  ++
  EFC36131.1  92 HlfglNKKSNDKKDEKEAaaKAHRVQENTWFSLYYTISSIAGFLI 136
                 145554444444444444335555777777777777777766555 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.57
     DUF3899  61 skkstrplliiGlllivlsivll 83 
                 + + +r +l++G  ++v +++ l
  EFC36131.1 161 EYPLMREYLLVGAGFYVQALFTL 183
                 66889999******999888765 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.46
     DUF3899  64 strplliiGlllivls 79 
                  +++l+ iGl++  +s
  EFC36131.1 197 LVHHLVTIGLIYGCIS 212
                 4555566666665554 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.67
     DUF3899  67 plliiGlllivl 78 
                 ++++  l +++l
  EFC36131.1 252 LFVLFVLAFLLL 263
                 444333444443 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.089
     DUF3899  33 frklkklflkk...........skkddsyyeykekkk 58 
                 f  + k +++k           ++ dds+ e+ +kkk
  EFC36131.1 336 FSLISKIVWRKlvgrglddireDDVDDSDDEDDKKKK 372
                 4445555555555556755644333333333333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1041  (0.0580624); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 2427.40
//
Query:       EFC36132.1  [L=732]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (732 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       668  (0.0372581); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.32s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 4025.97
//
Query:       EFC36133.1  [L=891]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.6e-24   86.6   0.0    2.7e-24   85.8   0.0    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
    2.3e-22   79.6   0.1      4e-22   78.8   0.1    1.4  1  Pkinase         Protein kinase domain
  ------ inclusion threshold ------
      0.046   14.2  12.4        1.3    9.7   0.4    5.1  4  Chlam_PMP       Chlamydia polymorphic membrane protein (Chlam


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.8   0.0   4.6e-28   2.7e-24       2     127 ..     768     891 .]     767     891 .] 0.94

  Alignments for each domain:
  == domain 1  score: 85.8 bits;  conditional E-value: 4.6e-28
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ek 97 
                  +++kk+GeG+ G V+ g++k        +Va+K+lk+++  +e  ++ +ea+i+++l+hpnivk++g+ + +++ ++v+ey+++G+L+  + ++    
   EFC36133.1 768 SIEKKIGEGSNGIVYLGKWK------GKQVAIKSLKSDTIGDEIGDFEREAAILNSLSHPNIVKFYGISMTSNHRYMVVEYINHGSLDRLIYNSriGV 859
                  689*****************......899*************************************************************99985557 PP

                  TTSBHHHHHHHHHHHHHHHHHHHHTT..EEES CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskk..lvHr 127
                  ++l+lk++l++ + vA+Gm+yL++ +  ++Hr
   EFC36133.1 860 STLNLKRKLDILISVANGMKYLHTLNppIIHR 891
                  899********************987668998 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.8   0.1   6.7e-26     4e-22       3     122 ..     769     891 .]     767     891 .] 0.89

  Alignments for each domain:
  == domain 1  score: 78.8 bits;  conditional E-value: 6.7e-26
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH..HHSS.--HH CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle..rkgs.lsee 98 
                  ++k+GeGs+G Vy ++  ++gk+vA+K +k + + ++   ++ rE +il++l+hpniv++y++  +++++y+v+ey+++g+l++l+   r  + +s  
  EFC36133.1 769 IEKKIGEGSNGIVYLGK--WKGKQVAIKSLKSDTIGDEIG-DFEREAAILNSLSHPNIVKFYGISMTSNHRYMVVEYINHGSLDRLIYnsR--IgVSTL 862
                 689*************9..9****************9885.9********************************************99542..334444 PP

                 HHH...HHHHHHHHHHHHHHHTT..EE-S CS
     Pkinase  99 eak...kiakqilegleylHskg..iiHr 122
                 ++k   +i+ ++++g++ylH  +  iiHr
  EFC36133.1 863 NLKrklDILISVANGMKYLHTLNppIIHR 891
                 44433489************888889998 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.6       1.1   6.8e+03       4       9 ..     289     294 ..     287     297 .. 0.82
   2 ?    9.7   0.4   0.00021       1.3       3      28 .]     415     430 ..     413     430 .. 0.90
   3 ?    5.4   0.3    0.0051        30       6      28 .]     442     454 ..     441     454 .. 0.84
   4 ?    3.9   0.0     0.015        89       5      27 ..     468     480 ..     465     481 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.1
   Chlam_PMP   4 FsnNta 9  
                 F+nN++
  EFC36133.1 289 FENNKV 294
                 9****9 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00021
   Chlam_PMP   3 tFsnNtatvsstptpaaggGGAIyae 28 
                 +F++N+a          ++GGA y e
  EFC36133.1 415 YFNGNKA----------VKGGAVYIE 430
                 69*****..........*******75 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0051
   Chlam_PMP   6 nNtatvsstptpaaggGGAIyae 28 
                 nN+a            GGAIya+
  EFC36133.1 442 NNSA----------LMGGAIYAK 454
                 7777..........89*****96 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.015
   Chlam_PMP   5 snNtatvsstptpaaggGGAIya 27 
                  +Nta            GGAI+ 
  EFC36133.1 468 DYNTA----------QLGGAIFV 480
                 67888..........9*****96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (891 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       820  (0.045736); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.79u 0.31s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 5126.58
//
Query:       EFC36134.1  [L=1168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-09   36.1  14.4      9e-09   35.3  14.4    1.4  1  Zn_clus        Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.3  14.4     5e-13     9e-09       2      39 ..     690     726 ..     689     727 .. 0.96

  Alignments for each domain:
  == domain 1  score: 35.3 bits;  conditional E-value: 5e-13
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 aCd+Cr++++KCd++kP+C +C++++ +C  y+es+++
  EFC36134.1 690 ACDHCRSQHRKCDKRKPSCYSCQQRGINCH-YRESKRN 726
                 9*****************************.***9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1549  (0.0863963); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.90u 0.41s 00:00:01.31 Elapsed: 00:00:00.61
# Mc/sec: 5779.88
//
Query:       EFC36135.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0014   18.5   1.8      0.011   15.6   1.8    2.0  1  Apolipoprotein   Apolipoprotein A1/A4/E domain
     0.0032   15.5   8.6      0.018   13.0   8.6    1.9  1  Prominin         Prominin
  ------ inclusion threshold ------
      0.011   16.0   4.7      0.032   14.5   0.1    3.0  3  Uteroglobin      Uteroglobin family
      0.015   16.0   3.8       0.59   10.9   0.3    3.1  3  RhoGAP-FF1       p190-A and -B Rho GAPs FF domain
      0.021   13.9   3.3      0.042   12.9   3.3    1.5  1  Clusterin        Clusterin
      0.052   14.1   1.3      0.052   14.1   1.3    2.2  2  NPA              Nematode polyprotein allergen ABA-1
      0.052   13.8  10.0       0.12   12.6   0.6    2.5  2  Cor1             Cor1/Xlr/Xmr conserved region
      0.053   13.6  13.4        3.9    7.5   3.6    3.2  3  ApoLp-III        Apolipophorin-III precursor (apoLp-III)
      0.065   13.2  10.7      0.075   13.0   1.2    2.2  2  Serine_rich      Serine rich protein interaction domain
      0.072   13.4   3.8        1.3    9.4   0.2    3.2  3  DUF5601          Domain of unknown function (DUF5601)
       0.11   12.7   9.0          2    8.6   0.5    2.2  2  Fib_alpha        Fibrinogen alpha/beta chain family
       0.12   12.8   0.4       0.12   12.8   0.4    2.8  2  Snapin_Pallidin  Snapin/Pallidin
       0.12   12.5   3.0       0.38   10.8   0.7    2.2  2  DUF4449          Protein of unknown function (DUF4449)
       0.13   12.5  14.9        2.3    8.6   3.5    4.0  3  DUF948           Bacterial protein of unknown function (DUF94
       0.17   11.8   1.5         27    4.7   0.1    2.8  3  ApoO             Apolipoprotein O
       0.25   11.0   2.2        3.3    7.4   0.1    2.9  3  Nbl1_Borealin_N  Nbl1 / Borealin N terminal
       0.29   11.8   2.8         14    6.4   0.1    2.7  3  DUF883           Bacterial protein of unknown function (DUF88
       0.36   10.7   7.2       0.42   10.5   0.3    2.9  3  Phage_Mu_Gam     Bacteriophage Mu Gam like protein
        0.5    9.9   5.1       0.99    8.9   5.1    1.5  1  Exonuc_VII_L     Exonuclease VII, large subunit
       0.61   10.1   7.9        4.2    7.4   0.2    3.0  3  Phasin           Poly(hydroxyalcanoate) granule associated pr
        0.7    9.9  13.6        4.2    7.4   2.6    2.5  3  Baculo_PEP_C     Baculovirus polyhedron envelope protein, PEP
       0.77   10.3   6.6    3.6e+02    1.8   6.6    3.3  1  YtxH             YtxH-like protein
        1.2    8.4  11.0        8.6    5.5   0.2    3.5  3  DUF2130          Uncharacterized protein conserved in bacteri
        1.6    8.8   5.8    1.1e+02    2.8   5.8    2.8  1  Mis12            Mis12 protein
        5.2    8.2   7.4         31    5.7   0.2    3.3  3  RNase_J_C        Ribonuclease J C-terminal domain


Domain annotation for each model (and alignments):
>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   1.8   1.5e-05     0.011      36     165 ..      15     165 ..       7     181 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.5e-05
                     HHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHH....HHHHCHHCCHHCHCCHCHH..................HHHHH CS
  Apolipoprotein  36 eelrarlraeleevrarlepyrdevqeqlgqnleelrqrlapyteelre....rlaadaeelqeqlavyaee..................lrerl 108
                     +e++ ++++ ++ + + l++ r++++ +++++l el+   +   ++l +    ++++ ++e++e ++   ++                  ++  +
      EFC36135.1  15 KEVSHAIETSTNKLESLLKNIRNDMKGTVEKSLHELKTC-KVWFQKLVDrvghQALHTVQEAKEMIDDFTAKillqfsqklkvlldkidnFQHLI 108
                     333333333333333333333333333333333333333.2233333334444555666666666666666677777777777777777799999 PP

                     HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH-----..-----SSSHHHHHHHTS-T CS
  Apolipoprotein 109 erhvealkarlapyveelrqklaerleelkeslaphaeeveerlssrveelreklee 165
                     e+hv ++  ++a +  e+ + +++ l+   + ++   ++ +e l++ ++++++++e 
      EFC36135.1 109 ETHVTEILNNIALLCSEFSSLVRAVLDKTDQIVDKTIKATQEGLNEMLQQFSQSVEL 165
                     999999999999999999999999999999999999999999999999999999987 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   8.6   2.5e-05     0.018     229     415 ..      16     170 ..       4     229 .. 0.43

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.5e-05
    Prominin 229 tlesnvlpaLaelerllenlkeakeqLeqvnklekeLrksgsqLrdglrgvkrdlnqalsnlCqs.eeCskilssleiekldtskcldqlpnvdevlea 326
                 +++ +                               +  s+++L++ l+++++d++ +++++ ++ ++C+   ++l   ++   + l ++++ +e++++
  EFC36135.1  16 EVSHA-------------------------------IETSTNKLESLLKNIRNDMKGTVEKSLHElKTCKVWFQKLVD-RVG-HQALHTVQEAKEMIDD 81 
                 33333...............................344444444444444444444444433332444444444322.121.2222344444444444 PP

    Prominin 327 leevletnlssivkeglarlneipekvknqtaevvpdlkkalakgreqikklakkiprealdavisdle.nterssktfddvvekyekyr 415
                  +  +  ++s++ k  l+++++ +++++++++e+++++    ++ ++ ++ +  k  ++++d++i++ +  +++ +++f++ ve  +++ 
  EFC36135.1  82 FTAKILLQFSQKLKVLLDKIDNFQHLIETHVTEILNNIALLCSEFSSLVRAVLDKT-DQIVDKTIKATQeGLNEMLQQFSQSVELTNNTA 170
                 44444444444444444444444444444444444444444444444444444444.444444444444444444444444444333332 PP

>> Uteroglobin  Uteroglobin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.1      0.99   7.1e+02      30      65 ..      16      53 ..       9      69 .. 0.73
   2 ?    0.7   0.1      0.91   6.5e+02      54      85 ..      67      98 ..      63     102 .. 0.81
   3 ?   14.5   0.1   4.5e-05     0.032       9      61 ..     116     171 ..     109     179 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.99
                 HHHHHHHS-HHHHHHHHHTT---..HHHHHHHHHHHHH CS
  Uteroglobin 30 vvekflegseeeYkeeLqkynpd..peaeealaelKqc 65
                 +v+  +e s++++++ L++  +d   ++e+ l elK c
   EFC36135.1 16 EVSHAIETSTNKLESLLKNIRNDmkGTVEKSLHELKTC 53
                 66677777777777777755444114578888888888 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.91
                 HHHHHHHHHHHHHTTS-HHHHHHHHHHHHHHH CS
  Uteroglobin 54 eaeealaelKqcvdklsnetkenvakllekil 85
                 +a + ++e K+ +d+++ + + ++++ l+ +l
   EFC36135.1 67 QALHTVQEAKEMIDDFTAKILLQFSQKLKVLL 98
                 57788899999999999999999988777665 PP

  == domain 3  score: 14.5 bits;  conditional E-value: 4.5e-05
                  XXXXXXXXXXXX...X---HHHHHHHHHHHHS-HHHHHHHHHTT---HHHHHHHHH CS
  Uteroglobin   9 LvalaLccyags...aegCpaleevvekflegseeeYkeeLqkynpdpeaeealae 61 
                  L  +aL+c++ s   + + ++ +++v+k+++ ++e ++e Lq+++++ e  +++a+
   EFC36135.1 116 LNNIALLCSEFSslvRAVLDKTDQIVDKTIKATQEGLNEMLQQFSQSVELTNNTAK 171
                  667899**99773434667777899*********************9999888776 PP

>> RhoGAP-FF1  p190-A and -B Rho GAPs FF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.3   0.00082      0.59       1      56 [.      12      68 ..      12      85 .. 0.90
   2 ?    3.7   0.0      0.14     1e+02       8      27 ..      95     114 ..      90     119 .. 0.81
   3 ?    0.9   0.0         1   7.5e+02       9      44 ..     129     164 ..     123     170 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00082
  RhoGAP-FF1  1 eAakarkellesatdayekLirkqVtdyralWssvskklskeke.feeyvelfGtek 56
                +Aak+ +  +e++t+++e+L+++  +d++ + ++   +l++ k  f++ v+ +G+++
  EFC36135.1 12 DAAKEVSHAIETSTNKLESLLKNIRNDMKGTVEKSLHELKTCKVwFQKLVDRVGHQA 68
                89***************************************9983588888888776 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.14
  RhoGAP-FF1   8 ellesatdayekLirkqVtd 27 
                 ++l +  d++++Li+++Vt+
  EFC36135.1  95 KVLLDKIDNFQHLIETHVTE 114
                 56667789**********97 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 1
  RhoGAP-FF1   9 llesatdayekLirkqVtdyralWssvskklskeke 44 
                 l+ ++ d+ ++++ k+++  ++  +++ +++s++ e
  EFC36135.1 129 LVRAVLDKTDQIVDKTIKATQEGLNEMLQQFSQSVE 164
                 667788899999999999999999999999888766 PP

>> Clusterin  Clusterin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   3.3   5.9e-05     0.042     121     251 ..      31     155 ..      11     184 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 5.9e-05
   Clusterin 121 fsfwlneeridsllvseedeeedaeleqledsfsqlssdvdslfnrslkvfkqmqqefdqafqsaflsdldlteee..flpalskarksrllrslglen 217
                 ++  ++++ + +       e++ +el++    f++l ++v++   + ++ +k+m   f +++  +f+++l++   +  ++++l++++ +++l+++    
  EFC36135.1  31 LLKNIRNDMKGT------VEKSLHELKTCKVWFQKLVDRVGHQALHTVQEAKEMIDDFTAKILLQFSQKLKVLLDKidNFQHLIETHVTEILNNI--AL 121
                 444444444444......4477899*********************************************9997776677777777777777776..34 PP

   Clusterin 218 lfqpffdfsrsvfesvsevvtetleavedekkqk 251
                 l + f  + r v+++ +++v++t++a+++  ++ 
  EFC36135.1 122 LCSEFSSLVRAVLDKTDQIVDKTIKATQEGLNEM 155
                 5666666666666666666666654444333222 PP

>> NPA  Nematode polyprotein allergen ABA-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   1.3   7.2e-05     0.052      34      96 ..      22      86 ..       7     103 .. 0.84
   2 ?   -2.4   0.0       9.8     7e+03       7      20 ..     191     204 ..     187     207 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 7.2e-05
         NPA 34 eeiekkvlefyealeadkkeeareklk..gaCkeyikkllgeeeaeelkklkesgasaeelkkkl 96
                e+  +k++ +++++ +d k ++++ l   + Ck +++kl+     + l++++e+++  +++ +k+
  EFC36135.1 22 ETSTNKLESLLKNIRNDMKGTVEKSLHelKTCKVWFQKLVDRVGHQALHTVQEAKEMIDDFTAKI 86
                45678889****************9983358********************99999999988876 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 9.8
         NPA   7 kleeflkWlteeqk 20 
                 ++ + +kWl++ q 
  EFC36135.1 191 AYRDGMKWLDKVQH 204
                 6788999**98885 PP

>> Cor1  Cor1/Xlr/Xmr conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   2.2     0.037        26      40     104 ..      21      86 ..       7     104 .. 0.66
   2 ?   12.6   0.6   0.00016      0.12      10      73 ..     126     189 ..     124     193 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.037
        Cor1  40 keeysqqfltlfqqwetdvqkvke.qeeklsnlfqqqqkllqqarvvqeqrlkeikqlydqFlksl 104
                  e  ++++++l+++   d++ + e    +l       qkl++++     ++ +e+k++ d+F+ ++
  EFC36135.1  21 IETSTNKLESLLKNIRNDMKGTVEkSLHELKTCKVWFQKLVDRVGHQALHTVQEAKEMIDDFTAKI 86 
                 456677788888888888876654245566666667788888888888888888888888887554 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 0.00016
        Cor1  10 leefvkaslkssnekieqvwktqqeerqklkeeysqqfltlfqqwetdvqkvkeqeeklsnlfq 73 
                 +++ v+a l+++++ ++++ k+ qe  +++ +++sq ++ + +  ++ vq+++e   k++n+++
  EFC36135.1 126 FSSLVRAVLDKTDQIVDKTIKATQEGLNEMLQQFSQSVELTNNTAKILVQDTNETVWKVANITE 189
                 5677999***********************************************9999999875 PP

>> ApoLp-III  Apolipophorin-III precursor (apoLp-III)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   3.5     0.013       9.1     106     144 ..      13      51 ..       8     103 .. 0.51
   2 ?    5.0   7.2     0.034        24      32     125 ..      58     160 ..      44     175 .. 0.51
   3 ?    7.5   3.6    0.0055       3.9      35     139 ..      98     202 ..      93     204 .. 0.52

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.013
   ApoLp-III 106 laeslkensqeakeklakaikqayddaveaaqklakqLk 144
                 +a++++ ++++ ++kl+ ++k++ +d+  + +k   +Lk
  EFC36135.1  13 AAKEVSHAIETSTNKLESLLKNIRNDMKGTVEKSLHELK 51 
                 333444444444444444444433333333333333333 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.034
   ApoLp-III  32 enlvdqlkqvikslqeelkkksdel.eealkevkkkieetadklse.......enPevkkkaqelqekvQsgvqslvkesqkl.aeslkensqeakekl 121
                 ++lvd++   +  + +e+k+ +d + +++l ++ +k++   dk+ +       +  e+  ++  l +++ s v++++  ++++ ++++k+  ++ +e l
  EFC36135.1  58 QKLVDRVGHQALHTVQEAKEMIDDFtAKILLQFSQKLKVLLDKIDNfqhlietHVTEILNNIALLCSEFSSLVRAVLDKTDQIvDKTIKATQEGLNEML 156
                 566666655554444555554444414666677777777766666655554444455555555555555555555554444331233444444444444 PP

   ApoLp-III 122 akai 125
                 +++ 
  EFC36135.1 157 QQFS 160
                 4433 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0055
   ApoLp-III  35 vdqlkqvikslqeelkkksdeleealkevkkkieetadklseenPevkkkaqelqekvQsgvqsl...vkesqklaeslkensqeakeklakaikqayd 130
                 +d++ ++++ ++  +++  ++++ + +e+ + +  + dk  +    v k ++++qe + + +q+    v+ ++++a+ l ++++e+  k+a+ ++ ay 
  EFC36135.1  98 LDKIDNFQHLIETHVTEILNNIALLCSEFSSLVRAVLDKTDQ---IVDKTIKATQEGLNEMLQQFsqsVELTNNTAKILVQDTNETVWKVANITEGAYR 193
                 566666666666666666666666666665555555555444...233333333333333333220003334566666666666666677777777776 PP

   ApoLp-III 131 daveaaqkl 139
                 d ++ + k+
  EFC36135.1 194 DGMKWLDKV 202
                 666666666 PP

>> Serine_rich  Serine rich protein interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   3.0     0.017        12       8     102 ..      12     114 ..       7     117 .. 0.82
   2 ?   13.0   1.2    0.0001     0.075      37     120 ..     111     194 ..     108     205 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.017
  Serine_rich   8 etlarlqqevesavskLlsfvsskWRs..kenleanlqeirlavdrlrtslrefleFargalanaaklsd.......knlqtkLrkqlqkledsdqil 96 
                  +  +++ +++e++++kL s+++ + R   k  +e+ l+e++++   +++ +  + + a  ++  a ++ d        + ++kL+ +l+k+++ ++++
   EFC36135.1  12 DAAKEVSHAIETSTNKLESLLK-NIRNdmKGTVEKSLHELKTCKVWFQKLVDRVGHQALHTVQEAKEMIDdftakilLQFSQKLKVLLDKIDNFQHLI 108
                  5667888999999999999986.555434788899999999999999999999999999999999999888998877788899999999999998888 PP

  Serine_rich  97 qetsqe 102
                  +++ +e
   EFC36135.1 109 ETHVTE 114
                  887665 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 0.0001
  Serine_rich  37 nleanlqeirlavdrlrtslrefleFargalanaaklsdknlqtkLrkqlqkledsdqilqetsqeLdsceWslealasdkkqe 120
                  ++ + l++i l ++++++ +r +l+ +++++    k+++++l++ L++  q +e ++++ +   q+ +++ W++  +++   ++
   EFC36135.1 111 HVTEILNNIALLCSEFSSLVRAVLDKTDQIVDKTIKATQEGLNEMLQQFSQSVELTNNTAKILVQDTNETVWKVANITEGAYRD 194
                  66778999******************************************************************9998876655 PP

>> DUF5601  Domain of unknown function (DUF5601)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.2    0.0019       1.3       4      61 ..      58     113 ..      51     116 .. 0.81
   2 ?    3.2   0.1      0.15   1.1e+02      14      36 ..     146     168 ..     125     189 .. 0.71
   3 ?   -0.8   0.0       2.8     2e+03       6      25 ..     219     238 ..     217     239 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0019
     DUF5601   4 ksfvrki.sqrsisieelSemVqdFyqnlaerlnktplyktvsseavedlldeiEkyim 61 
                 ++ v+++ +q   ++ e+ em+ dF  ++  +++++   k v  ++++++   iE++++
  EFC36135.1  58 QKLVDRVgHQALHTVQEAKEMIDDFTAKILLQFSQK--LK-VLLDKIDNFQHLIETHVT 113
                 3445555446799**********************9..66.889999999999999998 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.15
     DUF5601  14 sisieelSemVqdFyqnlaerln 36 
                 +++ e l em q+F q+ +   n
  EFC36135.1 146 KATQEGLNEMLQQFSQSVELTNN 168
                 56667889********9865555 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 2.8
     DUF5601   6 fvrkisqrsisieelSemVq 25 
                 +++ is++++++++l  +V+
  EFC36135.1 219 VLSIISIKFLTPDNLIRLVS 238
                 67789999*******99986 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   2.5    0.0041         3      27     119 ..      15     109 ..      11     125 .. 0.72
   2 ?    8.6   0.5    0.0028         2      22      71 ..     130     179 ..     127     197 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0041
                 CCCCCCCCHHHCCCCCCCCCCCCHHHHH.HHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHCCCHHHHHHHCCH.HHHHHHHHHHHHHHHHHH CS
   Fib_alpha  27 lkyekdvkkdlekleneleeisnstkea.eelvkeikdslrekqkskkdn.dnvikksskeleeeilrlketidaqe.snirvLqnvlesneqkiq 119
                 +++ + ++++ +kle+ l++i+n  k + e+  +e+k+     qk  +    ++++ +++  e  i ++ ++i  q+ ++++vL + +++ ++ i+
  EFC36135.1  15 KEVSHAIETSTNKLESLLKNIRNDMKGTvEKSLHELKTCKVWFQKLVDRVgHQALHTVQEAKE-MIDDFTAKILLQFsQKLKVLLDKIDNFQHLIE 109
                 567788999999*********999886515666777766665566555444444444444444.66699999999999999999999998777665 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0028
                 HHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  22 lqdlllkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqks 71 
                 ++ +l+k+++ v+k+++  ++ l+e+ ++ +++ el++++ ++l ++ ++
  EFC36135.1 130 VRAVLDKTDQIVDKTIKATQEGLNEMLQQFSQSVELTNNTAKILVQDTNE 179
                 56789********************9999999999999999999887665 PP

>> Snapin_Pallidin  Snapin/Pallidin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   1.4      0.86   6.2e+02      18      56 ..      43      80 ..      16     110 .. 0.55
   2 ?   12.8   0.4   0.00016      0.12       3      69 ..     122     188 ..     120     190 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.86
  Snapin_Pallidin 18 ldeklkelrqsQeeLleqldrl.nekLkeleeaqeaevlp 56
                     ++++l+el+++    ++ +dr  +++L+ ++ea+e  ++ 
       EFC36135.1 43 VEKSLHELKTCKVWFQKLVDRVgHQALHTVQEAKE--MID 80
                     44555555555555555555542334454444444..444 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 0.00016
  Snapin_Pallidin   3 Laegllellepkldeldeklkel.rqsQeeLleqldrlnekLkeleeaqeaevlpdlkeyakKLvnik 69 
                      L +++++l+  +ld++d+ + ++ +++Qe L+e+l++ +++++ ++++++  +++d++e + K++ni 
       EFC36135.1 122 LCSEFSSLVRAVLDKTDQIVDKTiKATQEGLNEMLQQFSQSVELTNNTAK-ILVQDTNETVWKVANIT 188
                      56789999************8761678***************98888888.88999999999999986 PP

>> DUF4449  Protein of unknown function (DUF4449)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.7   0.00053      0.38      35     100 ..      14      80 ..      11     112 .. 0.85
   2 ?    1.8   0.1      0.33   2.4e+02      33      69 ..     136     172 ..     119     202 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00053
     DUF4449  35 qkalekqirdaleklDaelyevkqeaerakeeaksdpenapniysryldalkkkftkkkekaeek.e 100
                 +k ++++i ++ +kl++ l +++++++ + e++ ++ +  ++ +++++d++ +++ ++ ++a+e  +
  EFC36135.1  14 AKEVSHAIETSTNKLESLLKNIRNDMKGTVEKSLHELKTCKVWFQKLVDRVGHQALHTVQEAKEMiD 80 
                 688999**************************99999999****************99999999533 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.33
     DUF4449  33 aiqkalekqirdaleklDaelyevkqeaerakeeaks 69 
                    ++++k+i+ + e l ++l + +q +e + ++ak 
  EFC36135.1 136 KTDQIVDKTIKATQEGLNEMLQQFSQSVELTNNTAKI 172
                 3344688888888888888888888888877776665 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   1.2      0.16   1.2e+02      39      61 ..      51      80 ..       9      88 .. 0.46
   2 ?    7.3   0.9    0.0075       5.4      18      75 ..      88     146 ..      82     150 .. 0.83
   3 ?    8.6   3.5    0.0032       2.3      27      76 ..     137     190 ..     133     204 .. 0.70

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.16
      DUF948 39 e.......kqvdpilkevedllakvnelle 61
                +       k vd + +++  ++++++e+ +
  EFC36135.1 51 KtckvwfqKLVDRVGHQALHTVQEAKEMID 80
                233333334444444444444444444444 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0075
      DUF948  18 ivvllklkktldeaaatieelekqvdpilkevedllakvnelledvneklek.vdplte 75 
                   +  klk +ld++ ++ + +e +v++il++++ l ++   l+  v +k+++ vd+ ++
  EFC36135.1  88 LQFSQKLKVLLDKIDNFQHLIETHVTEILNNIALLCSEFSSLVRAVLDKTDQiVDKTIK 146
                 5566788999*******************************999999999873455555 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0032
      DUF948  27 tldeaaatieelekqvdpilkevedllakvne....lledvneklekvdpltea 76 
                 t + + +ti+ +++ ++++l++  + ++ +n+    l++d ne + kv ++te 
  EFC36135.1 137 TDQIVDKTIKATQEGLNEMLQQFSQSVELTNNtakiLVQDTNETVWKVANITEG 190
                 445556666666666666666666666666665555888999888888888875 PP

>> ApoO  Apolipoprotein O
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1     0.037        27      10      53 ..      22      65 ..       9      84 .. 0.77
   2 ?    0.1   0.0         1   7.5e+02      15      61 ..      78     124 ..      65     134 .. 0.74
   3 ?    4.7   0.2     0.038        27      26      67 ..     140     181 ..     124     191 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.037
        ApoO 10 eeptdrLeegvrslRkslepytsavqdelnkvkskvetaeqsvt 53
                e+ t++Le+  +++R+ ++ ++++  +el++ k ++++++  v 
  EFC36135.1 22 ETSTNKLESLLKNIRNDMKGTVEKSLHELKTCKVWFQKLVDRVG 65
                78899999999999999999999999999999998888887664 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 1
        ApoO  15 rLeegvrslRkslepytsavqdelnkvkskvetaeqsvtdtiasLke 61 
                 ++  + +++ ++++++++ + d+++++++ +et ++ + ++ia L +
  EFC36135.1  78 MIDDFTAKILLQFSQKLKVLLDKIDNFQHLIETHVTEILNNIALLCS 124
                 55556666667788888888888999999888888888888887765 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.038
        ApoO  26 slepytsavqdelnkvkskvetaeqsvtdtiasLkeppedll 67 
                  + ++++a+q+ ln++ +++ ++++ +++t + L ++  +++
  EFC36135.1 140 IVDKTIKATQEGLNEMLQQFSQSVELTNNTAKILVQDTNETV 181
                 566788899999999999999999999999999998876655 PP

>> Nbl1_Borealin_N  Nbl1 / Borealin N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.1    0.0045       3.3      11      40 ..      15      44 ..      11      45 .. 0.88
   2 ?    1.9   0.1      0.25   1.8e+02       6      34 ..     101     129 ..      99     137 .. 0.88
   3 ?   -1.0   0.0       1.9   1.4e+03      13      37 ..     141     165 ..     130     168 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0045
  Nbl1_Borealin_N 11 lEveeRirrlraelelllktlrnrfelell 40
                     +Ev + i+   ++le+llk++rn ++ ++ 
       EFC36135.1 15 KEVSHAIETSTNKLESLLKNIRNDMKGTVE 44
                     7999999999*************9998765 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.25
  Nbl1_Borealin_N   6 LenfdlEveeRirrlraelelllktlrnr 34 
                      ++nf++ +e+ + ++ ++ +ll+ ++++ 
       EFC36135.1 101 IDNFQHLIETHVTEILNNIALLCSEFSSL 129
                      899***9****************999876 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 1.9
  Nbl1_Borealin_N  13 veeRirrlraelelllktlrnrfel 37 
                      v+  i++  + l+ +l+++++  el
       EFC36135.1 141 VDKTIKATQEGLNEMLQQFSQSVEL 165
                      6777777778888888888887776 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.3     0.063        45      19      69 ..      22      72 ..       5      86 .. 0.44
   2 ?    1.3   0.1      0.76   5.5e+02       6      39 ..      49      82 ..      44     114 .. 0.71
   3 ?    6.4   0.1     0.019        14       5      66 ..     128     189 ..     124     194 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.063
      DUF883 19 keaadeageeaeelRerleerlerarerlrdaeeavaerakeaaeaaddyV 69
                +++ ++ ++ ++++R+ ++ ++e++ ++l+  +   ++ ++++ ++a + V
  EFC36135.1 22 ETSTNKLESLLKNIRNDMKGTVEKSLHELKTCKVWFQKLVDRVGHQALHTV 72
                333333333333333333333333333333333333333333333333333 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.76
      DUF883  6 eleslladleellkeaadeageeaeelRerleer 39
                el++     ++l+++ + +a ++++e++e +++ 
  EFC36135.1 49 ELKTCKVWFQKLVDRVGHQALHTVQEAKEMIDDF 82
                5666666677788888888888888888877765 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.019
      DUF883   5 aeleslladleellkeaadeageeaeelRerleerlerarerlrdaeeavaerakeaaeaad 66 
                 + ++++l++++++++++ + ++e ++e+ ++ ++++e + ++++ + ++  e + ++a+ ++
  EFC36135.1 128 SLVRAVLDKTDQIVDKTIKATQEGLNEMLQQFSQSVELTNNTAKILVQDTNETVWKVANITE 189
                 667999*******************************9999999999998888888877665 PP

>> Phage_Mu_Gam  Bacteriophage Mu Gam like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.2      0.54   3.9e+02      14      43 ..      21      50 ..       7      64 .. 0.44
   2 ?   10.5   0.3   0.00058      0.42      18      62 ..      72     116 ..      66     120 .. 0.91
   3 ?    2.1   0.1      0.23   1.7e+02      18      60 ..     134     176 ..     129     192 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.54
                  HHHHHHHHHHHHHHHHHHHHHHHHHHCHHH CS
  Phage_Mu_Gam 14 lkreleeieaeaneeiaaikekleaelepl 43
                  ++++ +++e+ +++ ++ +k   e++l +l
    EFC36135.1 21 IETSTNKLESLLKNIRNDMKGTVEKSLHEL 50
                  333333333333333333333333444433 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00058
                   HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCTH CS
  Phage_Mu_Gam  18 leeieaeaneeiaaikekleaeleplkkeieylesllkqYaeank 62 
                   ++e+++ +++  a+i  ++ ++l+ l ++i+ +++l+++ +++  
    EFC36135.1  72 VQEAKEMIDDFTAKILLQFSQKLKVLLDKIDNFQHLIETHVTEIL 116
                   6899999********************************998866 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.23
                   HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHC CS
  Phage_Mu_Gam  18 leeieaeaneeiaaikekleaeleplkkeieylesllkqYaea 60 
                   l++  + +++ i+a +e l++ l++  ++ e  +++ k  ++ 
    EFC36135.1 134 LDKTDQIVDKTIKATQEGLNEMLQQFSQSVELTNNTAKILVQD 176
                   5666677777777777777777777777777666666665555 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   5.1    0.0014      0.99     135     245 ..      14     148 ..      11     192 .. 0.44

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0014
  Exonuc_VII_L 135 Aelvvpdkaeleeqleelerrlekaikrlleekkqr.......leklasrlk.speellerkrqrldeleerleralkkqlkkkrerleelkerlke 223
                   A+ v++ +++ +++le+l +++++ +k ++e++ ++       ++kl  r+  ++ + ++++++ +d++++++  + +++lk    +++++++ +++
    EFC36135.1  14 AKEVSHAIETSTNKLESLLKNIRNDMKGTVEKSLHElktckvwFQKLVDRVGhQALHTVQEAKEMIDDFTAKILLQFSQKLKVLLDKIDNFQHLIET 110
                   5555555555555555555555555554443333330000111334444443366666667777777777766666666666666666666644443 PP

  Exonuc_VII_L 224 kleekkerlkklkerle................lleek 245
                   +++e  ++++ l ++++                +++++
    EFC36135.1 111 HVTEILNNIALLCSEFSslvravldktdqivdkTIKAT 148
                   33333333322222222222221112222212211111 PP

>> Phasin  Poly(hydroxyalcanoate) granule associated protein (phasin)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.3     0.099        71      45      96 ..      11      47 ..       4      54 .. 0.38
   2 ?    7.4   0.2    0.0059       4.2      36     101 ..      56     121 ..      50     135 .. 0.84
   3 ?    2.8   0.2      0.16   1.1e+02      47      78 ..     133     164 ..     122     184 .. 0.61

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.099
      Phasin 45 eklekktkkvaeekleevresvkskveevkekaeeqwdklekafdervakaL 96
                +++ k+  +++               e+ ++k+e+ ++++ + ++ +v+k+L
  EFC36135.1 11 KDAAKEVSHAI---------------ETSTNKLESLLKNIRNDMKGTVEKSL 47
                33333333333...............33333333333333333333333333 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0059
      Phasin  36 lfeaLvkeGeklekktkkvaeekleevresvkskveevkekaeeqwdklekafdervakaLsrlgv 101
                  f++Lv++  +   +t ++a+e +++ + ++  ++++  + + ++ d+ ++++++ v+++L+++ +
  EFC36135.1  56 WFQKLVDRVGHQALHTVQEAKEMIDDFTAKILLQFSQKLKVLLDKIDNFQHLIETHVTEILNNIAL 121
                 589999887777778888899999999999999999999999999999999999999999998865 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.16
      Phasin  47 lekktkkvaeekleevresvkskveevkekae 78 
                 + +kt + +++++++ +e +++++++ ++ +e
  EFC36135.1 133 VLDKTDQIVDKTIKATQEGLNEMLQQFSQSVE 164
                 33455666666666666666666666655554 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.2     0.023        17      32      69 ..      17      54 ..      11      86 .. 0.61
   2 ?    7.4   2.6    0.0059       4.2      47     103 ..      72     128 ..      47     150 .. 0.68
   3 ?    6.5   8.9     0.011       8.2      34     118 ..      92     180 ..      78     205 .. 0.66

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.023
  Baculo_PEP_C 32 ilaqlatlldaietqLnalsedlksllaeldtrldtll 69
                  ++ +++t  +++e+ L+++ +d+k  +++  ++l+t  
    EFC36135.1 17 VSHAIETSTNKLESLLKNIRNDMKGTVEKSLHELKTCK 54
                  55566667777777777777666665555555555544 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0059
  Baculo_PEP_C  47 LnalsedlksllaeldtrldtlltnLtdalnalqdtlrneLtnlnsiltnLlssvtN 103
                   +++ +e + +  a++  ++++ l+ L d++ ++q  ++++ t + ++++ L s+   
    EFC36135.1  72 VQEAKEMIDDFTAKILLQFSQKLKVLLDKIDNFQHLIETHVTEILNNIALLCSEFSS 128
                   334444444444455557777777777777777777777777777777777776544 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.011
  Baculo_PEP_C  34 aqlatlldaietqLnalsedlksllaeldt...rldtlltnLtdalnalq.dtlrneLtnlnsiltnLlssvtNinstLnnllqalnnl 118
                    +l+ lld+i++  + +++++++ l++++    ++++l+ ++ d+  ++  +t++   ++ln  l +   sv  +n+t + l+q+ n +
    EFC36135.1  92 QKLKVLLDKIDNFQHLIETHVTEILNNIALlcsEFSSLVRAVLDKTDQIVdKTIKATQEGLNEMLQQFSQSVELTNNTAKILVQDTNET 180
                   34444555555554555555555555544444488888888888888877678888889999999999999988888888888876654 PP

>> YtxH  YtxH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   6.6      0.51   3.6e+02      23      53 ..      10      69 ..       6     191 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.51
        YtxH 23 GketRkdlkekaddlkekakelleeakeka.............................k 53
                Gk+  k+++++ +++ +k+++ll+++++ +                              
  EFC36135.1 10 GKDAAKEVSHAIETSTNKLESLLKNIRNDMkgtvekslhelktckvwfqklvdrvghqaL 69
                777777777777777777777776666666666666666666664444444444433331 PP

>> DUF2130  Uncharacterized protein conserved in bacteria (DUF2130)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.2     0.012       8.6     210     253 ..      11      54 ..       6      58 .. 0.88
   2 ?    4.9   2.4     0.019        13     173     240 ..      68     146 ..      63     187 .. 0.61
   3 ?    1.7   0.1      0.18   1.3e+02     137     167 ..     194     227 ..     184     237 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.012
     DUF2130 210 qkaieeidkelekikekleksinklllatigmygnkieelkikk 253
                 ++a +e++ ++e+  +kle+  +++++ + g++++++ elk  k
  EFC36135.1  11 KDAAKEVSHAIETSTNKLESLLKNIRNDMKGTVEKSLHELKTCK 54 
                 67788888889****************************99876 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.019
     DUF2130 173 elenvkekneditefetkkeefkekfrknieaavekfqkaieeidke..............lekikekleksinklllatig 240
                 +l +v+e +e+i++f     ++  +f+++++  ++k+++ +  i++                    +++ +++++++++ti+
  EFC36135.1  68 ALHTVQEAKEMIDDFTA---KILLQFSQKLKVLLDKIDNFQHLIETHvteilnniallcseFSSLVRAVLDKTDQIVDKTIK 146
                 56667777777777777...77777777777777777777776666655543332222222333333333333333333333 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.18
     DUF2130 137 egiv...eyekmyvvrpqffiplitiLrqaliks 167
                 +g++   +++ +++ ++  fi+l+++L  ++ik 
  EFC36135.1 194 DGMKwldKVQHLWIYHYLPFIVLLMVLSIISIKF 227
                 45555559999****************9888875 PP

>> Mis12  Mis12 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   5.8      0.16   1.1e+02      44      70 ..       8      34 ..       4     191 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.16
                .TTSTHHHH-HHHHHHHHHHHHHHHHH CS
       Mis12 44 eeeekaaeesteeieeGtakletllea 70
                e+ ++aa+e ++ ie +t+kle+ll++
  EFC36135.1  8 EAGKDAAKEVSHAIETSTNKLESLLKN 34
                456778889999999999999999987 PP

>> RNase_J_C  Ribonuclease J C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.2     0.043        31      20      58 ..      11      49 ..       6      54 .. 0.84
   2 ?    2.4   0.2      0.46   3.3e+02      12      58 ..      72     118 ..      69     120 .. 0.86
   3 ?    2.9   0.1      0.32   2.3e+02      17      47 ..     132     162 ..     122     184 .. 0.65

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.043
   RNase_J_C 20 eeakkvvretieealeekesdwnelkrkirealkkflyk 58
                ++a+k v+++ie++ ++ es  ++++++++ +++k l++
  EFC36135.1 11 KDAAKEVSHAIETSTNKLESLLKNIRNDMKGTVEKSLHE 49
                688999999999999999999999999999999987765 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.46
   RNase_J_C  12 vkeseeLieeakkvvretieealeekesdwnelkrkirealkkflyk 58 
                 v+e++e+i++ ++++     ++l+    + ++ ++ i + +++ l++
  EFC36135.1  72 VQEAKEMIDDFTAKILLQFSQKLKVLLDKIDNFQHLIETHVTEILNN 118
                 79999******999999999999998899999999999999888765 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.32
   RNase_J_C  17 eLieeakkvvretieealeekesdwnelkrk 47 
                  +++++ ++v +ti+ ++e  +   ++ +++
  EFC36135.1 132 AVLDKTDQIVDKTIKATQEGLNEMLQQFSQS 162
                 4566777777777777776644444444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1669  (0.0930894); expected 358.6 (0.02)
Passed bias filter:                      660  (0.0368119); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              25  [number of targets reported over threshold]
# CPU time: 0.80u 0.38s 00:00:01.18 Elapsed: 00:00:00.56
# Mc/sec: 1448.35
//
Query:       EFC36136.1  [L=397]
Description: RNase H [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.1e-13   50.1   0.0    6.7e-13   49.0   0.0    1.6  1  RNase_H   RNase H
  ------ inclusion threshold ------
       0.09   12.7   0.1       0.17   11.9   0.1    1.4  1  DUF98     p-hydroxybenzoic acid synthase


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.0   0.0   7.5e-17   6.7e-13       4     142 ..      61     186 ..      58     187 .. 0.83

  Alignments for each domain:
  == domain 1  score: 49.0 bits;  conditional E-value: 7.5e-17
                 EEEEEEEEEECTTTCEEEEEEECTT.....EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSBHT CS
     RNase_H   4 vvvYtDGsclgnpgeggagavlykeg...arnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkpvk 99 
                   +YtDGs ++ +++ g g+ ++k++   ++++s+++ ++ + n aEL+A+ +a k l  ++k +i+tDSk  ++ i++        +++ + +   +k
  EFC36136.1  61 FEIYTDGS-KMDENSTGFGIYFHKGViegNEQLSFNIDGRYSHNVAELTAILMASKLLPNNSKATIFTDSKISID-ILN-------PRYDGKFSI--FK 148
                 679*****.557888899999998888766799***********************999****************.776.......233334444..66 PP

                 THHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHHH CS
     RNase_H 100 nkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkeaa 142
                   + + ++  + k+ k++l++vkgH     +N  +D+lAk+++
  EFC36136.1 149 D-EFYRTI--FDKNLKIKLEKVKGHVDP--NNIIVDELAKKGS 186
                 6.666666..57899**********866..8*********986 PP

>> DUF98  p-hydroxybenzoic acid synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   1.9e-05      0.17      49     115 ..     225     294 ..     195     321 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.9e-05
                 EEEEEEEETTEEEEEEEEE..EEGGGS-HHHHH.SSS-HHHHHHHTT--BEEEEEEEEEEE--HHHHHHT CS
       DUF98  49 rRqVwlrangqklayAeSw..wneeelekylke.kdqpiwksLtkerlelfReirglalgeadeLeeafg 115
                  R+  +  ++++l+  + w   n++ l+++l+   +  iw+++t++++  ++ + + + g+  eLe+ + 
  EFC36136.1 225 DRRATIARDKSNLIITKGWssANIKYLNSHLEPyTKFCIWRNMTNNHIRQYKPVSCSHCGRIVELEHYIY 294
                 5777777788999998888335889999999754999**********************99999998654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       838  (0.0467399); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 2520.24
//
Query:       EFC36137.1  [L=460]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.14   12.4   0.0       0.34   11.2   0.0    1.7  1  Lir1        Light regulated protein Lir1


Domain annotation for each model (and alignments):
>> Lir1  Light regulated protein Lir1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   1.9e-05      0.34      23      88 ..      69     142 ..      48     159 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 1.9e-05
        Lir1  23 klailspa..kvaasslsslrsrvraaaavavdastvDysssisvf...PaeaCd.li...gGeaCsadiyPevk 88 
                 k+++++++  ++++ +l+s++++ +      +d +++Dy+  isvf   P ea + li    G+ C+    Pe k
  EFC36137.1  69 KQIVIANRtiNIKSVNLNSRQKKFSRNIK-MSDNKQIDYETCISVFvqqPNEAFEdLIvkeVGHLCNRIYVPELK 142
                 33333333014455555555555555554.7899************88888997524433336677766667765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1940  (0.108205); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 2731.41
//
Query:       EFC36138.1  [L=191]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.017   15.9   1.4      0.066   14.0   0.3    2.4  2  PulA_N1   Pullulanase N1-terminal domain


Domain annotation for each model (and alignments):
>> PulA_N1  Pullulanase N1-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.3   3.7e-06     0.066      21      84 ..      64     127 ..      57     128 .. 0.89
   2 ?   -0.5   0.0      0.12   2.1e+03      61      72 ..     132     143 ..     127     154 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.7e-06
                 TTS-S-EEEEESSEEEEEEEEEEEEESSEEEEEEE-SS---TTS--EEE-TTS-EEEEEE-GGG CS
     PulA_N1  21 egesssfllkeedekieLeikekeeleeevkYvckleeelelgkeylildehgnktdLqigaVi 84 
                 e++s+s l+++ +++++L+i+++++ e++     +l+e+l+ +++ +++d++  + ++q+ +++
  EFC36138.1  64 ENKSESSLTNKLKKDSDLNINHSQTTENKSALQNSLPEQLKKDSQFVVVDKYLASRKVQLHSIV 127
                 34455558889999********************************************999997 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.12
                 -TTS--EEE-TT CS
     PulA_N1  61 elgkeylildeh 72 
                 ++ + y+i+d++
  EFC36138.1 132 NFKTMYVIYDSS 143
                 688999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1362  (0.0759663); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1307.73
//
Query:       EFC36139.1  [L=256]
Description: C-4 sterol methyl oxidase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      1e-25   90.6  13.3      1e-25   90.6  13.3    2.1  2  FA_hydroxylase  Fatty acid hydroxylase superfamily


Domain annotation for each model (and alignments):
>> FA_hydroxylase  Fatty acid hydroxylase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.1     0.038   6.8e+02      51      69 ..      55      74 ..      39      91 .. 0.47
   2 !   90.6  13.3   5.7e-30     1e-25       2     133 .]      99     231 ..      98     231 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.038
  FA_hydroxylase 51 ealllallllllllllg.pl 69
                      l++ +l++l+++++  ++
      EFC36139.1 55 YLLFIYFLVILPMYAVAfHF 74
                    22222222222222222222 PP

  == domain 2  score: 90.6 bits;  conditional E-value: 5.7e-30
  FA_hydroxylase   2 llallledfveYwvHrllHrvkllwrrlHkvHHsseaptalaalrahpleallla.llllllllllgplsalllvlvlaallelliHsglhvslg 95 
                     ++++++ed+++Yw+Hr+lH+ ++ ++ +Hk+HH++e+pt l+++ ahple+l+l+ +++l +lll +++ +ll+++ l++l +  +Hsg +++++
      EFC36139.1  99 AFCFFMEDTAHYWFHRWLHT-PWAYHVIHKIHHEFESPTILSTSFAHPLEILILGfATFLGPLLLRPHFLTLLIFVNLRQLAACETHSGFDFPFS 192
                     7899***************6.8*********************************888889998888**********************666666 PP

  FA_hydroxylase  96 wll..erllatpraHrlHHskneegnfgvllslwDrlfgT 133
                     + +  + l+ ++ +H++HH++   g f++ + +wD  +gT
      EFC36139.1 193 PNNlaPNLIGGADFHDFHHRRCS-GVFSSNFMWWDIWCGT 231
                     65578889***************.***************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       818  (0.0456244); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1743.72
//
Query:       EFC36140.1  [L=468]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.6e-08   31.5   0.0      1e-07   31.1   0.0    1.1  1  p450           Cytochrome P450
    1.3e-05   24.8   0.0    6.2e-05   22.6   0.0    1.9  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.1   0.0   1.2e-11     1e-07       6     138 ..      10     140 ..       6     151 .. 0.83

  Alignments for each domain:
  == domain 1  score: 31.1 bits;  conditional E-value: 1.2e-11
                 EHHCCHCHHHHTTTCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGH.HHHHHHHHHHH CS
        p450   6 plplvgnllqlgrkeelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfang.ekwkklRrflt 103
                 ++p++  +l l ++e l +++  +     +++++   ++p v++s+p++ ke +i+kg+ f++   + +++    +f + ++l+a+  ekwkk+ +++ 
  EFC36140.1  10 RIPFLSTHLYLTSDEDLDKACLLYGDAETQTLSIATSTTPLVFISDPKMLKEYFITKGHLFEKP-GYEVVN----FFGEDNILTATNtEKWKKHYKICS 103
                 677777777777777777777777777888999*************************888885.666666....5888888888888*********** PP

                 HHHTSHSTT.THHHHHHHHHHHHHHHHHCCCCHCS..E CS
        p450 104 ptltsfgkl.sleelveeeaedlveklrkkagess..e 138
                 +++t + +l  + ++ +++ + l e ++++ +e++   
  EFC36140.1 104 AAFTPK-NLmYVCKVADKSCDLLFEIWNERLKENGsmI 140
                 ****99.888999****************999996333 PP

>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   6.9e-09   6.2e-05      22     233 .]     159     449 ..     151     449 .. 0.68

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 6.9e-09
                    HHHHHHHC..TTSEEEEEEEBSCTCHHHHHHHHH....TTCEEEEECCH............................................... CS
                    xxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxx............................................... RF
  Exo_endo_phos  22 ladlltay..daDvlgLQEvdddelsriplllal....ggflgasstsp............................................... 64 
                    +++++++   d Dv++LQEv+ ++ s +    +     +    ++ ++                                                
     EFC36140.1 159 VKKIIETIpkDLDVVFLQEVWLQSHSHLISEELKssypY----SF-HGHkevvneasctddsfhrfalpflhcvreknltlswttlgpcaeflsra 249
                    455554444356************999877777554330....22.22235677888888888888888888888888999999999999999999 PP

                    ...............................ECSSSTTSSEEEEEECSTEEEEEEEEEEETSSSSGCEEEEEEEEEEEEEEECCCHHGHHHHHHHH CS
                    ...............................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  65 ...............................tgggggggnggavlsrfpltslfrrtfiefndlvaalrreplaakleqlniashrdhdlvrdlql 129
                                                     + ++g ng++vls+ p+ +  +++++ f                                   
     EFC36140.1 250 aygnfkciscvltsvvenkniancytpghtgQEFLYDGSNGLMVLSKTPISRANYTSYPSFL---------------------------------- 311
                    99999999999999999999999999999999******************999776666644.................................. PP

                    HHHHHHHHHHHHHTTSEEEE...............................................EEE-SSSTSGGGBSCGHHHHHHCTTTHH. CS
                    xxxxxxxxxxxxxxxxxxxx...............................................xxxxxxxxxxxxxxxxxxxxxxxxxxxx. RF
  Exo_endo_phos 130 lalllqvealnadrgapviv...............................................aGDfNarpsdddsrvlrtrglalapapv. 177
                                       +                                               +GD+N+       +++++ g         
     EFC36140.1 312 -------------------LsrgllemcinglfimeshfpfnfgidlpvmyqpefsrmvimkrpnilVGDLNS------GPLTQPEG-------Ye 375
                    ...................355555555566666788888888888888888888888888888888999999......22222222.......02 PP

                    .................SSCESCETTTTTTTTTTTEB-BEEEEEECHHHCCEEEEEEECCHHEEC........TSSCSSSB CS
                    .................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxx RF
  Exo_endo_phos 178 .................glyllgggptptyvtraggsrlDrilaspalalfrsgvlppplalvrr........ealtlSDH 233
                                       ++l++++      +  +  +D+i++ +    f++   + + +   +           t+SDH
     EFC36140.1 376 tlagygyqsidpnkatfCVNGLNWEIGDCSDDPERNTGMDHIMVDK----FSRILEWNSNN---SfklqlfgdSTPTPSDH 449
                    2222333444444555555555555555555555555558887775....33333332222...14446666677777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       377  (0.0210274); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.24s 00:00:00.77 Elapsed: 00:00:00.42
# Mc/sec: 3329.10
//
Query:       EFC36141.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-17   63.1  27.4    1.7e-08   33.9   4.9    5.6  6  Pentapeptide     Pentapeptide repeats (8 copies)
    1.1e-15   57.5  36.6    5.9e-08   32.8   5.7    4.5  4  Pentapeptide_4   Pentapeptide repeats (9 copies)
    1.8e-10   40.8  33.9    4.6e-05   23.5   6.6    5.5  4  Pentapeptide_3   Pentapeptide repeats (9 copies)
  ------ inclusion threshold ------
        2.7    8.0  14.4        1.1    9.3   0.8    3.4  4  Mitochondr_Som1  Mitochondrial export protein Som1


Domain annotation for each model (and alignments):
>> Pentapeptide  Pentapeptide repeats (8 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   4.9   3.8e-12   1.7e-08       1      39 [.       9      47 ..       9      47 .. 0.98
   2 !   21.6   2.7   2.7e-08   0.00012      17      40 .]      51      74 ..      50      74 .. 0.81
   3 !   17.7   2.2   4.5e-07     0.002       1      26 [.      65      90 ..      65      91 .. 0.94
   4 ?   -0.9   0.0      0.31   1.4e+03      13      29 ..     106     122 ..     105     123 .. 0.77
   5 !    6.9   0.2    0.0011       4.9      10      23 ..     126     139 ..     125     146 .. 0.54
   6 !    5.8   0.0    0.0025        11      28      38 ..     152     162 ..     149     163 .. 0.57

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 3.8e-12
                  -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEEC CS
  Pentapeptide  1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLs 39
                  +n+s +nLs ++L+++ ++++++++Anls+++L+ a ++
    EFC36141.1  9 CNFSSVNLSSCSLKKVLFKECDFNSANLSNSNLESAQFR 47
                  9**********************************9886 PP

  == domain 2  score: 21.6 bits;  conditional E-value: 2.7e-08
                  CCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide 17 nlsgAnLtgAnlsgAdLsganLsg 40
                  n+s AnLt++nl  A+++++++++
    EFC36141.1 51 NFSAANLTSCNLKYACFENCDFQN 74
                  788888888888888888888875 PP

  == domain 3  score: 17.7 bits;  conditional E-value: 4.5e-07
                  -B-TT-B-CCSCCEECCCESEEECT- CS
  Pentapeptide  1 AnLsgAnLsganLsganlsgAnLtgA 26
                  A+++++++++ +++++n ++A+++++
    EFC36141.1 65 ACFENCDFQNIDFTNSNPENATFRNC 90
                  89**********************98 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.31
                   CEECCCESEEECT-B-T CS
  Pentapeptide  13 LsganlsgAnLtgAnls 29 
                   L+g  + ++ + ++++ 
    EFC36141.1 106 LKGKVFVNTLFKDCEFW 122
                   77888888888888875 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0011
                   CSCCEECCCESEEE CS
  Pentapeptide  10 ganLsganlsgAnL 23 
                   ga+++++ ++ +n+
    EFC36141.1 126 GAKFENCEFESCNM 139
                   55555555555554 PP

  == domain 6  score: 5.8 bits;  conditional E-value: 0.0025
                   -TT-EECCEEE CS
  Pentapeptide  28 lsgAdLsganL 38 
                   ++++dLsga++
    EFC36141.1 152 FNQCDLSGAIF 162
                   55555555554 PP

>> Pentapeptide_4  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.8   5.7   1.3e-11   5.9e-08      24      69 ..       2      47 ..       1      51 [. 0.90
   2 !   28.0   7.9   4.1e-10   1.8e-06      10      62 ..      38      91 ..      38      92 .. 0.95
   3 !    6.8   5.3    0.0016       7.3       7      33 ..     110     139 ..      93     146 .. 0.56
   4 !   10.8   8.9   9.2e-05      0.41       7      56 ..     110     170 ..     104     206 .. 0.66

  Alignments for each domain:
  == domain 1  score: 32.8 bits;  conditional E-value: 1.3e-11
  Pentapeptide_4 24 rdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfs 69
                     d++F++c++s+vn+++c+l++v f e+d+++a++s++nl+++ f+
      EFC36141.1  2 DDTTFESCNFSSVNLSSCSLKKVLFKECDFNSANLSNSNLESAQFR 47
                    6899999999999999999999999999999999999999999995 PP

  == domain 2  score: 28.0 bits;  conditional E-value: 4.1e-10
  Pentapeptide_4 10 ncklsnvnFsea.rlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcn 62
                    n++l+ ++F+ + ++ ++n+t+c+l+++ F++c+++++df++ ++ +a+F +c+
      EFC36141.1 38 NSNLESAQFRSCrNFSAANLTSCNLKYACFENCDFQNIDFTNSNPENATFRNCT 91
                    789999******89**************************************97 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0016
  Pentapeptide_4   7 sfnncklsnvnF...searlrdcnFtecrl 33 
                      f n+ +++++F   s a++++c F++c++
      EFC36141.1 110 VFVNTLFKDCEFwkqSGAKFENCEFESCNM 139
                     455555555555222233666666666665 PP

  == domain 4  score: 10.8 bits;  conditional E-value: 9.2e-05
  Pentapeptide_4   7 sfnncklsnvnF...searlrdcnFtecrl........snvnFdecnlsdvdfaevdlkra 56 
                      f n+ +++++F   s a++++c F++c++         + +F++c+ls + f   ++++ 
      EFC36141.1 110 VFVNTLFKDCEFwkqSGAKFENCEFESCNMfgycfsddWENSFNQCDLSGAIFPSLNYFKG 170
                     6788888888884334459999999999997777776545557777776666665555444 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   1.8   1.9e-07   0.00084      12      47 ..       1      34 [.       1      35 [. 0.93
   2 !   23.5   6.6     1e-08   4.6e-05       1      46 [.      31      74 ..      31      76 .. 0.97
   3 !   19.4   8.8     2e-07    0.0009       2      48 .]      42      91 ..      41      91 .. 0.93
   4 !    5.2   6.4    0.0051        23      29      44 ..     125     139 ..      95     170 .. 0.59

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 1.9e-07
  Pentapeptide_3 12 FrgatFsgaasFsnadFgsadFsgarFtgdvdFsga 47
                    ++++tF+++ +Fs+ +++s+++ ++ F+ ++dF+ a
      EFC36141.1  1 MDDTTFESC-NFSSVNLSSCSLKKVLFK-ECDFNSA 34
                    689******.9****************9.****977 PP

  == domain 2  score: 23.5 bits;  conditional E-value: 1e-08
  Pentapeptide_3  1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsg 46
                    F+ an+s++ +++ a F+++ +Fs a+++s+++  a F+ ++dF +
      EFC36141.1 31 FNSANLSNS-NLESAQFRSCRNFSAANLTSCNLKYACFE-NCDFQN 74
                    99*******.**********99*****************.****87 PP

  == domain 3  score: 19.4 bits;  conditional E-value: 2e-07
  Pentapeptide_3  2 sganFsgaadFrgatFsgaas.....FsnadFgsadFsgarFtgdvdFsgat 48
                    + a+F+ + +F+ a+ +++ +     F+n+dF+++dF +++ + +++F+++t
      EFC36141.1 42 ESAQFRSCRNFSAANLTSC-NlkyacFENCDFQNIDFTNSNPE-NATFRNCT 91
                    679****************.667899****************9.******97 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0051
  Pentapeptide_3  29 gsadFsgarFtgdvdF 44 
                     ++a F+++ F+  +++
      EFC36141.1 125 SGAKFENCEFE-SCNM 139
                     24444444443.3332 PP

>> Mitochondr_Som1  Mitochondrial export protein Som1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.8   0.00025       1.1      30      56 ..      12      38 ..       2      52 .. 0.79
   2 ?    6.7   1.9    0.0016       7.2      24      68 ..      47      95 ..      34     107 .. 0.72
   3 ?   -0.7   0.3      0.32   1.4e+03      11      39 ..     104     134 ..      95     155 .. 0.58
   4 ?   -3.5   0.0       2.4   1.1e+04      34      43 ..     272     282 ..     245     284 .. 0.54

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00025
  Mitochondr_Som1 30 eeveLkkCeLkelvQyeCtfkeskkee 56
                     ++v+L++C+Lk+++  eC+f++ + ++
       EFC36141.1 12 SSVNLSSCSLKKVLFKECDFNSANLSN 38
                     5678****************9987554 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0016
  Mitochondr_Som1 24 ekkrkeeeveLkkCeLkelvQyeCtfkeskkeekekk....iiClpvkR 68
                      + r+ + ++L++C+Lk     +C+f++   ++++ +      C+p+ +
       EFC36141.1 47 RSCRNFSAANLTSCNLKYACFENCDFQNIDFTNSNPEnatfRNCTPILK 95
                     4455567778****************99775554444466678888765 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.32
  Mitochondr_Som1  11 seleervqvkekl..ekkrkeeeveLkkCeL 39 
                      + l+ +v v++     + +k++ ++ ++Ce 
       EFC36141.1 104 ESLKGKVFVNTLFkdCEFWKQSGAKFENCEF 134
                      4455444333332323334444444555554 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 2.4
  Mitochondr_Som1  34 Lkk.CeLkelv 43 
                      Lk+  +L +l+
       EFC36141.1 272 LKNkKQLQKLI 282
                      33324455555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       749  (0.0417759); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 1922.79
//
Query:       EFC36142.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.9e-11   42.4   1.1    1.7e-10   41.2   1.1    1.6  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.096   12.9   0.1       0.21   11.8   0.1    1.5  1  DicB      DicB protein


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.2   1.1   1.9e-14   1.7e-10       2     112 ..      48     183 ..      47     186 .. 0.89

  Alignments for each domain:
  == domain 1  score: 41.2 bits;  conditional E-value: 1.9e-14
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHH..HHHHHHHCSS............... CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklr..eelekrleke............... 83 
                 ++++l +++   lF +F e+ f+ e +  w a+e+fk+ k+++++ + +++I n+y+  ++p elni++k +   e+ k +e                 
  EFC36142.1  48 IRKILLNEKWNDLFLKFSEKCFACEDVMMWNAIEKFKAIKSEKQRRELFYNICNTYIRLGAPLELNISRKDFgiPEIMKTFEALresairgssgspsgt 146
                 5789999*************************************************************98651133444444336778*********** PP

                 .........STTTTTTHHHHHHHHHHHHHHHHHHHHTS CS
         RGS  84 .........qpsrklfeeaqeevfellekdsypkFlks 112
                            ++++f+++q+++   +  d y++F+ s
  EFC36142.1 147 dspkkrtifAITSEMFDRIQTACEHNML-DNYTRFQAS 183
                 **************************95.789999987 PP

>> DicB  DicB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   2.3e-05      0.21      11      46 ..      65     101 ..      61     110 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.3e-05
        DicB  11 seGcfei.GvtisnPvftedainkrkqerellnkici 46 
                 se cf    v + n +    ai   kq rel+  ic 
  EFC36142.1  65 SEKCFACeDVMMWNAIEKFKAIKSEKQRRELFYNICN 101
                 8999987359999***999*****************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1015  (0.0566122); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1371.76
//
Query:       EFC36143.1  [L=1084]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1084 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       983  (0.0548274); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.83u 0.31s 00:00:01.13 Elapsed: 00:00:00.50
# Mc/sec: 6583.60
//
Query:       EFC36144.1  [L=132]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       574  (0.0320152); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.34s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 734.34
//
Query:       EFC36145.1  [L=459]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
        0.6   10.6   5.1       0.16   12.4   1.3    2.0  2  Packaging_FI  DNA packaging protein FI
        7.3    6.6   9.5       0.16   11.9   1.2    2.3  2  DUF1151       Protein of unknown function (DUF1151)


Domain annotation for each model (and alignments):
>> Packaging_FI  DNA packaging protein FI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.3   1.8e-05      0.16      10      75 ..      93     160 ..      85     180 .. 0.74
   2 ?   -2.1   0.1      0.55   4.9e+03      37      66 ..     364     393 ..     327     413 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.8e-05
                   XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXX------- CS
  Packaging_FI  10 reLgtqLnrdvsvsGtaeeLalrvaeleeeld..dvdesaGqdaadsrdstehedevesadsDeaive 75 
                   +eL+t L r   v+G +  L   +   eee +  +++    ++a+ s  st+ +++++s +s + +  
    EFC36145.1  93 QELATTLYRTSTVTGKQPTLDFVMNRQEEEGNnsSMNSVKKNNASTSSFSTDLHNSMQSMNSHQQDSS 160
                   79*******************99999999988443334455566667777888888887777665544 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.55
                   XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Packaging_FI  37 eeelddvdesaGqdaadsrdstehedeves 66 
                   eee +++  + G++  + + s+  +++ ++
    EFC36145.1 364 EEEKNSIATTVGNKLLLKTSSSSLTPTLNN 393
                   455555555555555555555555555555 PP

>> DUF1151  Protein of unknown function (DUF1151)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   1.2   1.8e-05      0.16      12      96 ..      78     163 ..      67     172 .. 0.81
   2 ?   -1.9   1.7      0.36   3.2e+03      70      75 ..     230     235 ..     204     286 .. 0.47

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.8e-05
     DUF1151  12 lanpvleskshqeLhrELllnqkr.glvleeKpELqrvlekrkeeqvlkqkkeeeeakkkkseLeqelekraqrleelekeeekqk 96 
                 l n+  + + +++  +EL  +  r  +v  + p L  v++++ ee + +  ++ ++++  +s + + l++  q +++ ++++++ +
  EFC36145.1  78 LRNTFNSPSIQRQSPQELATTLYRtSTVTGKQPTLDFVMNRQEEEGNNSSMNSVKKNNASTSSFSTDLHNSMQSMNSHQQDSSSSS 163
                 45555544445566789988876658899999********************************************8888776654 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.36
     DUF1151  70 kkseLe 75 
                 ++s+++
  EFC36145.1 230 CNSPFG 235
                 333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1839  (0.102571); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.53
# Mc/sec: 2616.87
//
Query:       EFC36146.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 2144.57
//
Query:       EFC36147.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.042   14.1   0.2      0.078   13.2   0.2    1.4  1  Herpes_UL14  Herpesvirus UL14-like protein


Domain annotation for each model (and alignments):
>> Herpes_UL14  Herpesvirus UL14-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   4.3e-06     0.078      23      92 ..     198     264 ..     188     283 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.3e-06
  Herpes_UL14  23 LellseGvstqdPaFveaFtaAkeaeedlkaqlrsdaRlesvrrkikriqakveeqaelrsiLkanRryl 92 
                  L   seG s +  +F +  t+ k +e   +aq  ++ R++ ++ k + ++ ++eeq++++  L+    +l
   EFC36147.1 198 LTSSSEGLSESSKEFKYTKTKQKRKE---RAQNNTSIRVANIESKLQLMKLQLEEQTKIEGTLQKATGFL 264
                  55578999999999998776666655...45667899**********************99998776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1495  (0.0833845); expected 358.6 (0.02)
Passed bias filter:                      634  (0.0353617); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2094.89
//
Query:       EFC36148.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-33  114.2   8.6    1.5e-07   31.0   0.1    5.6  6  DUF4116        Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.068   13.4   0.1       0.62   10.3   0.1    2.2  2  DUF1433        Protein of unknown function (DUF1433)
       0.14   12.2   0.2       0.32   11.1   0.2    1.5  1  Fe_dep_repr_C  Iron dependent repressor, metal binding and di


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.1   2.5e-11   1.5e-07      19      49 .]      32      62 ..      29      62 .. 0.96
   2 !   24.0   0.0   3.8e-09   2.3e-05       1      30 [.      64      96 ..      64     101 .. 0.91
   3 !   17.6   0.0   3.9e-07    0.0023      16      37 ..     107     128 ..      99     135 .. 0.83
   4 !   20.1   0.1   6.7e-08    0.0004      12      34 ..     133     155 ..     127     155 .. 0.87
   5 !   20.8   0.0   3.9e-08   0.00023      16      49 .]     162     195 ..     158     195 .. 0.88
   6 !   22.5   0.1   1.1e-08   6.8e-05       1      39 [.     172     210 ..     172     214 .. 0.91

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 2.5e-11
     DUF4116 19 lseeLknDkeivlkAvkqngtalsyaseeLr 49
                +s++L+nDke+v++A +++ + ++yas eLr
  EFC36148.1 32 VSKRLRNDKEVVMAAFEKDYSQFKYASSELR 62
                79****************************8 PP

  == domain 2  score: 24.0 bits;  conditional E-value: 3.8e-09
     DUF4116  1 DrEivleavkkn...gsalkylseeLknDkeiv 30
                DrE+vl + +++   g++l+y+s++L++Dk+++
  EFC36148.1 64 DREFVLLLARSFgdiGLVLEYISSDLTSDKDFM 96
                9*********9955566***************9 PP

  == domain 3  score: 17.6 bits;  conditional E-value: 3.9e-07
     DUF4116  16 lkylseeLknDkeivlkAvkqn 37 
                 + y++ eL++Dk++vl+++ ++
  EFC36148.1 107 FGYFPIELRSDKDFVLQIIGKS 128
                 679**************99765 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 6.7e-08
     DUF4116  12 ngsalkylseeLknDkeivlkAv 34 
                 n + l++ls++Lk DkeivlkAv
  EFC36148.1 133 NLEFLRHLSDNLKADKEIVLKAV 155
                 5567899***************8 PP

  == domain 5  score: 20.8 bits;  conditional E-value: 3.9e-08
     DUF4116  16 lkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                  + l+  L nD+ei+l Av++   +++++s+eL+
  EFC36148.1 162 TQQLDIYLNNDREIALTAVRKERLVFRFLSKELQ 195
                 567788899***********************97 PP

  == domain 6  score: 22.5 bits;  conditional E-value: 1.1e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 DrEi+l av+k  +++++ls+eL++D ei +  +++ g+
  EFC36148.1 172 DREIALTAVRKERLVFRFLSKELQSDEEIQKYMIESFGN 210
                 9****************************8888887776 PP

>> DUF1433  Protein of unknown function (DUF1433)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.13   7.9e+02      22      63 ..      19      57 ..      11      74 .. 0.70
   2 ?   10.3   0.1    0.0001      0.62      17      76 ..     144     204 ..     135     217 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.13
     DUF1433 22 svtFtelkesPmgvavieGYindnkeldFvAsisteenfefg 63
                s++F e k++P+    ++  + ++ke+   A  +   +f++ 
  EFC36148.1 19 SIHFKE-KRQPLR--AVSKRLRNDKEVVMAAFEKDYSQFKYA 57
                677755.455654..566778899999999988888888875 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.0001
     DUF1433  17 vkeiksvtFtelkesPmgvavieGYindnkeldFvAsisteenfef.gtalskseeldkll 76 
                 +k  k +    +  +   +++++ Y+n+++e+  +A  + +  f f  ++l+++ee++k +
  EFC36148.1 144 LKADKEIVLKAVFPNEYSTQQLDIYLNNDREIALTAVRKERLVFRFlSKELQSDEEIQKYM 204
                 555555555555556666778899**************9999**995678*******9865 PP

>> Fe_dep_repr_C  Iron dependent repressor, metal binding and dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   5.3e-05      0.32       5      31 ..     173     199 ..     172     206 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.3e-05
                    HHHHHHHHHHHHHHHHHHHHHCT--CC CS
  Fe_dep_repr_C   5 relAkrlvrrhrllerfLvdvlgvdwe 31 
                    re+A+  vr+ rl+ rfL++ l+ d+e
     EFC36148.1 173 REIALTAVRKERLVFRFLSKELQSDEE 199
                    79*******************997665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       522  (0.0291148); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.32s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1393.38
//
Query:       EFC36149.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.8e-16   59.5   0.1    2.6e-16   59.1   0.1    1.3  1  LSM         LSM domain
  ------ inclusion threshold ------
      0.035   14.2   0.3      0.039   14.0   0.3    1.2  1  SUIM_assoc  Unstructured region C-term to UIM in Ataxin3


Domain annotation for each model (and alignments):
>> LSM  LSM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.1   0.1   2.8e-20   2.6e-16       8      65 ..      42     112 ..      34     114 .. 0.95

  Alignments for each domain:
  == domain 1  score: 59.1 bits;  conditional E-value: 2.8e-20
                 TSEEEEEETTSEEEEEEEEEEETTSEEEEEEEEEEETTET.............EEEEEEEEEEEGGGEEEE CS
         LSM   8 nkkvtvelkngrelrGtLkgfDqfmNlvLedveetlkdkk.............ekrklglvliRGnnivli 65 
                 + ++++ ++n+r+l  ++k+fD+++N+vLe+v+e+++++              ++r+ +++++RG++++l+
  EFC36149.1  42 QTQILISCRNNRKLLARVKAFDRHCNMVLENVQEMWTEQPksgkgrkkskpinKTRFTNKLFLRGDSVILV 112
                 579**********************************9999***********999999***********98 PP

>> SUIM_assoc  Unstructured region C-term to UIM in Ataxin3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.3   4.3e-06     0.039       3      30 ..       2      55 ..       1      99 [. 0.68

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 4.3e-06
  SUIM_assoc  3 sqdvPqts.gtqltsEeLrkrreaYFEK.........................q 30
                sq v+ t+ + q t EeL k  e  FEK                          
  EFC36149.1  2 SQTVAATTeAPQKTAEELEKEEELLFEKgplslllesvreqtqiliscrnnrkL 55
                7777766514569***************99999888776655555555555550 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       687  (0.0383178); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.32s 00:00:00.76 Elapsed: 00:00:00.48
# Mc/sec: 742.35
//
Query:       EFC36150.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.4e-05   23.8   0.2    4.7e-05   22.9   0.2    1.5  1  Pkinase         Protein kinase domain
     0.0066   16.4   0.0      0.011   15.6   0.0    1.3  1  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.013   14.3   0.1      0.014   14.2   0.1    1.2  1  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.2   7.8e-09   4.7e-05     102     151 ..     205     253 ..     185     291 .. 0.82

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 7.8e-09
                 HHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSS CS
     Pkinase 102 kiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakeless 151
                  ++  +l  + +l +++i H D+KpeNi +  +++  ++DF +a++++ +
  EFC36150.1 205 AFFIDLLVQVCFLQKQQITHNDIKPENIVLY-DKHWFMIDFEIATKFSLE 253
                 55666777788999****************9.8999999******99865 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   1.9e-06     0.011     158     197 ..     209     248 ..     188     250 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.9e-06
                 HH--S...SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 158 allpg...elptvllHgDlhpgNllvdpddgrvtGviDfedag 197
                 +ll      ++++++H+D++p N+++  d++ +  +iDfe a+
  EFC36150.1 209 DLLVQvcfLQKQQITHNDIKPENIVLY-DKHWF--MIDFEIAT 248
                 555556667899***************.88888..*****886 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.1   2.4e-06     0.014     307     364 ..     202     252 ..      66     262 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.4e-06
  Pkinase_fungal 307 ellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsd 364
                     ++++ ++D +     L  k++i H+Di  +Ni+++      ++++++iD+++a++ s 
      EFC36150.1 202 NIMAFFIDLLVQVCFLQ-KQQITHNDIKPENIVLY------DKHWFMIDFEIATKFSL 252
                     55666666666666676.99***************......89**********99885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1854.09
//
Query:       EFC36151.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.071   13.5   0.0       0.13   12.7   0.0    1.4  1  Cys_rich_CWC  Cysteine-rich CWC


Domain annotation for each model (and alignments):
>> Cys_rich_CWC  Cysteine-rich CWC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   7.4e-06      0.13      16      37 ..      36      57 ..      31      77 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 7.4e-06
  Cys_rich_CWC 16 edisdCwCakqalsdkllqlls 37
                  ++ s+CwC++q++ ++ +++l+
    EFC36151.1 36 DNDSQCWCFQQRFYTTFQNQLR 57
                  4557*********776666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       524  (0.0292264); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 3064.45
//
Query:       EFC36152.1  [L=469]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-08   35.2   0.1    2.7e-08   34.1   0.1    1.6  1  TLD          TLD
  ------ inclusion threshold ------
        3.5    7.9 114.2        1.5    9.0  10.3    7.4  6  Laminin_EGF  Laminin EGF domain


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.1   0.1     3e-12   2.7e-08       2     138 ..     319     469 .]     318     469 .] 0.74

  Alignments for each domain:
  == domain 1  score: 34.1 bits;  conditional E-value: 3e-12
         TLD   2 lyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnk......kfygdsesflfsl..spkfkvykstgkn.....kaylntssdgl 87 
                 ly+++ +g    ++++ +++ ++t++++k++ + +fGa+ls pw++ n       k ++d + flfs+  s  ++ + + g++     ++ +n  +  +
  EFC36152.1 319 LYRAMGNGYHPYAFHNACNGYSSTVTIVKTSAGAVFGAYLSIPWEDYNAgdirilKTFSDPNAFLFSMvtSSGVERFVKLGYSgavgqTVTYNFIT-HP 416
                 7888888999999*******************************766666677779************9955555555534443233255555554.69 PP

         TLD  88 gfGggqpkfsLwidsslekgtsrhs....etfe..ngllsgaseerfkikdiEVWgl 138
                  fG      ++++ + + +           tf+   + +s  ++ +f ++d EV+++
  EFC36152.1 417 LFGA----SDIYLGQGMSFQPAPDAyskpATFQplEPNWSYGTTYSFTVSDYEVYSV 469
                 9**5....6899999877655444455667777432333338999*********975 PP

>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9  26.0       1.8   1.6e+04       3      42 ..      59      95 ..      25     101 .. 0.81
   2 ?    4.3  15.4     0.005        45      13      42 ..     101     137 ..      92     143 .. 0.74
   3 ?    6.3  16.7    0.0012        11       3      41 ..     143     178 ..     137     185 .. 0.76
   4 ?    2.2  11.7     0.023   2.1e+02       4      32 ..     186     211 ..     178     216 .. 0.76
   5 ?    3.3  10.4      0.01        91       3      32 ..     215     241 ..     211     245 .. 0.80
   6 ?    9.0  10.3   0.00017       1.5       3      40 ..     245     279 ..     243     285 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 1.8
                 CCTTTBCCSSEETTTECES.BTTTEESTTS-EE-TTEEEGT CS
  Laminin_EGF  3 CnphgsssssCdsstgqCl.CkenveGrkCdrCkpgyyglp 42
                 C+++    s C+ s g+C+ C  n +G +C  Ck g  g +
   EFC36152.1 59 CDSKC---SICE-SPGNCSqCSTNHDGATCSLCKTGWTGAT 95
                 33333...4555.5**********************98874 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.005
                  EET......TTECES.BTTTEESTTS-EE-TTEEEGT CS
  Laminin_EGF  13 Cds......stgqCl.CkenveGrkCdrCkpgyyglp 42 
                  Cds      s  +C+ C  n++G++C  Ck g  g +
   EFC36152.1 101 CDSkcttcgSPSVCSvCSGNYDGTTCSICKTGWSGIT 137
                  333333355699*******************988874 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0012
                  CCTTTBCCSSEETTTECES.BTTTEESTTS-EE-TTEEEG CS
  Laminin_EGF   3 CnphgsssssCdsstgqCl.CkenveGrkCdrCkpgyygl 41 
                  C+++    ++C s  g+C+ C  n +G++C  Ck g  g 
   EFC36152.1 143 CDSKC---TTCAS-PGVCSvCSGNWQGSTCSTCKTGWTGA 178
                  33333...55655.*********************99886 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.023
                  CTTTBCCSSEETTTECES.BTTTEESTTS- CS
  Laminin_EGF   4 nphgsssssCdsstgqCl.CkenveGrkCd 32 
                  +++    ++C  s gqC+ C  + +G +C 
   EFC36152.1 186 DSKC---TTCA-SPGQCSvCSAGWTGATCS 211
                  3333...5555.5****************7 PP

  == domain 5  score: 3.3 bits;  conditional E-value: 0.01
                  CCTTTBCCSSEETTTECES.BTTTEESTTS- CS
  Laminin_EGF   3 CnphgsssssCdsstgqCl.CkenveGrkCd 32 
                  C+++    ++C s  gqC+ C  + +G +C 
   EFC36152.1 215 CDSKC---TTCTS-PGQCSvCSSGWTGATCS 241
                  44444...66666.****************6 PP

  == domain 6  score: 9.0 bits;  conditional E-value: 0.00017
                  CCTTTBCCSSEETTTECES.BTTTEESTTS-EE-TTEEE CS
  Laminin_EGF   3 CnphgsssssCdsstgqCl.CkenveGrkCdrCkpgyyg 40 
                  C+++    ++C s  g+C+ C  n +G+ C  Ck    g
   EFC36152.1 245 CDSKC---TTCTS-PGVCSvCSGNWDGPSCSVCKTSWTG 279
                  44444...67766.********************98766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (469 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       726  (0.0404931); expected 358.6 (0.02)
Passed bias filter:                      226  (0.0126053); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.82u 0.37s 00:00:01.19 Elapsed: 00:00:00.61
# Mc/sec: 2323.52
//
Query:       EFC36153.1  [L=201]
Description: small GTPase, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.2e-05   24.1   0.0    4.6e-05   23.1   0.0    1.5  1  Ras         Ras family
     0.0023   17.8   0.4     0.0023   17.8   0.4    1.9  2  DUF3198     Protein of unknown function (DUF3198)
     0.0026   17.9   0.0     0.0045   17.2   0.0    1.4  1  Roc         Ras of Complex, Roc, domain of DAPkinase
     0.0075   16.1   0.3      0.017   15.0   0.3    1.7  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.032   14.1   0.1      0.066   13.1   0.1    1.5  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.0   1.3e-08   4.6e-05       1      55 [.     137     190 ..     137     200 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.3e-08
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEE CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDT 55 
                 Kl + G ++ G  s+++r+ +d+F+e+y+  +  + + k+++++++e+kleiw  
  EFC36153.1 137 KLCVSGPGGSGIHSFINRYLNDQFNEQYDYSL-DEVFYKNVQFNETELKLEIWEN 190
                 78899***************************.89999***************75 PP

>> DUF3198  Protein of unknown function (DUF3198)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.4   6.4e-07    0.0023      19      42 ..      36      59 ..      33      63 .. 0.91
   2 ?   -2.7   0.1       1.6   5.8e+03      30      41 ..     154     165 ..     152     170 .. 0.65

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 6.4e-07
                HHHHHHHHHHHHHH-SHHHHHHHH CS
     DUF3198 19 vknlkeLekiarklGssYqqrLee 42
                +knl +Le i++++G+ +q+ Le+
  EFC36153.1 36 IKNLCNLELISKQFGENFQNLLEN 59
                79********************97 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.6
                 HHH-SHHHHHHH CS
     DUF3198  30 rklGssYqqrLe 41 
                 r l  +++++++
  EFC36153.1 154 RYLNDQFNEQYD 165
                 566677777775 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   1.3e-06    0.0045       1      73 [.     137     200 ..     137     201 .] 0.81

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.3e-06
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT- CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslh 73 
                 K+++ G +g+G  s+++r+++d+f+e+++  +   f+ k+v ++++       +++kl+iW  +  ++++  h
  EFC36153.1 137 KLCVSGPGGSGIHSFINRYLNDQFNEQYDYSLDEVFY-KNV-QFNE-------TELKLEIWENGFRNDYYMFH 200
                 89999**********************9998877665.444.3332.......4689****999888887665 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.3   4.8e-06     0.017       3      18 ..       7      22 ..       6      49 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 4.8e-06
                HHHS-HHHHHHHHHTS CS
       F-box  3 lsrLPsevlrhILerL 18
                l +LP+e+lrhILe+L
  EFC36153.1  7 LTDLPPELLRHILEFL 22
                679***********98 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   1.8e-05     0.066       2      31 ..       8      49 ..       7      55 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.8e-05
  F-box-like  2 srLPdEiLlqIF............syLppsd.....LlrlalVCrrW 31
                 +LP+E+L +I+            s     +     L++l l ++++
  EFC36153.1  8 TDLPPELLRHILefliianpllarS-----EkniknLCNLELISKQF 49
                58**********4444443333332.....24455599999999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (201 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       984  (0.0548832); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1236.68
//
Query:       EFC36154.1  [L=132]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       460  (0.0256568); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 815.03
//
Query:       EFC36155.1  [L=455]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      4e-33  113.4  13.6    1.2e-12   47.8   0.0    6.4  6  PPR_2            PPR repeat family
    1.6e-25   87.5  12.4     0.0013   18.8   0.0    9.2  9  PPR              PPR repeat
    9.3e-15   54.5   0.9    3.8e-06   26.9   0.0    5.7  7  PPR_3            Pentatricopeptide repeat domain
    3.3e-14   52.8   4.3    1.8e-06   27.5   0.3    3.9  4  PPR_long         Pentacotripeptide-repeat region of PRORP
      2e-11   43.4  10.6      0.084   12.6   0.0    7.0  7  PPR_1            PPR repeat
    1.9e-08   34.4   1.7       0.11   12.8   0.0    4.6  4  ANAPC3           Anaphase-promoting complex, cyclosome, subun
    1.5e-06   28.0  12.0        1.2    9.0   0.0    6.9  6  ATP13            Mitochondrial ATPase expression
    2.5e-06   27.0   3.0       0.89    9.5   0.0    4.9  5  TPR_1            Tetratricopeptide repeat
    2.8e-06   27.4   1.3      0.054   13.6   0.2    3.3  3  FANCM-MHF_bd     FANCM to MHF binding domain
    1.3e-05   25.6   0.0         24    6.1   0.0    5.6  5  TPR_14           Tetratricopeptide repeat
    2.3e-05   24.8   0.0        2.6    8.6   0.0    5.3  7  TPR_19           Tetratricopeptide repeat
    0.00014   21.7   2.3        2.5    8.1   0.1    3.7  3  Mistic           Membrane-integrating protein Mistic
     0.0002   21.2   0.0        9.5    6.5   0.0    3.9  3  TPR_7            Tetratricopeptide repeat
    0.00047   20.4   0.0        2.7    8.3   0.0    4.0  3  TPR_12           Tetratricopeptide repeat
     0.0018   17.7   2.8        2.3    7.6   0.1    3.4  3  SNAP             Soluble NSF attachment protein, SNAP
     0.0068   16.5   4.7         68    4.1   0.0    5.8  5  TPR_8            Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.067   12.8   9.2        3.8    7.0   0.2    3.9  4  INTS5_N          Integrator complex subunit 5 N-terminus


Domain annotation for each model (and alignments):
>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1       1.6   1.7e+03      18      34 ..     150     166 ..     136     168 .. 0.77
   2 ?    2.0   0.1      0.23   2.4e+02       4      25 ..     205     226 ..     202     234 .. 0.87
   3 !   47.8   0.0   1.2e-15   1.2e-12       2      49 ..     236     283 ..     235     284 .. 0.97
   4 !   12.6   0.3   0.00012      0.12       7      28 ..     310     331 ..     306     338 .. 0.88
   5 !   42.7   0.0   4.3e-14   4.6e-11       2      49 ..     338     385 ..     337     386 .. 0.97
   6 !   12.4   0.1   0.00013      0.14       2      32 ..     407     437 ..     406     449 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.6
       PPR_2  18 kveeAfklfneMkkrgl 34 
                 ++ee + l++eM  +++
  EFC36155.1 150 NFEEGMTLLHEMNAQKI 166
                 6899999*****98777 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.23
       PPR_2   4 vtyNtlIsglckkgkveeAfkl 25 
                 v  +t+ + + k +++++A+++
  EFC36155.1 205 VLLTTMVNFYNKCEDYDKAIEI 226
                 7779***************986 PP

  == domain 3  score: 47.8 bits;  conditional E-value: 1.2e-15
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49 
                 d+ +yN+lI+ +  k +++ A++++ eM++++++P+s T++i++++++
  EFC36155.1 236 DTTSYNCLIQSYIGKSDLNRAIEMLAEMQQQNISPDSATFTIILTACA 283
                 899*******************************************97 PP

  == domain 4  score: 12.6 bits;  conditional E-value: 0.00012
       PPR_2   7 NtlIsglckkgkveeAfklfne 28 
                 N++I+ + k +k+++A++lf+ 
  EFC36155.1 310 NAMINFYNKCEKFDKAIELFES 331
                 ********************96 PP

  == domain 5  score: 42.7 bits;  conditional E-value: 4.3e-14
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49 
                 d+ +yN++I+ +  kg+++ A++++ eM+  +++P+s T +i++++++
  EFC36155.1 338 DTTSYNCVIQSYIGKGDLNGAIEILAEMQHLNISPDSATLTIILTACA 385
                 899*******************************************97 PP

  == domain 6  score: 12.4 bits;  conditional E-value: 0.00013
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkr 32 
                 + ++ +++I+ + k +k+++A++lf+   k 
  EFC36155.1 407 NNHSITSMINFYNKCEKFDKAIELFESVSKD 437
                 667889*******************986665 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.88   9.3e+02       4      17 ..      26      39 ..      24      40 .. 0.87
   2 ?    1.2   0.1      0.53   5.6e+02      15      27 ..     150     162 ..     148     166 .. 0.87
   3 !    7.4   0.0    0.0056       5.9       3      23 ..     207     227 ..     205     235 .. 0.84
   4 !   17.5   0.0   3.2e-06    0.0034       2      31 .]     239     268 ..     238     268 .. 0.94
   5 ?    5.0   0.0     0.032        34       2      23 ..     274     295 ..     273     297 .. 0.93
   6 !   17.1   0.1   4.5e-06    0.0047       3      28 ..     309     334 ..     307     337 .. 0.88
   7 !   18.8   0.0   1.3e-06    0.0013       2      30 ..     341     369 ..     340     370 .. 0.93
   8 ?    3.2   0.0      0.12   1.2e+02       2      24 ..     376     398 ..     375     404 .. 0.89
   9 !   15.4   0.0   1.6e-05     0.017       4      26 ..     412     434 ..     409     439 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.88
         PPR  4 nslIsgycknGkle 17
                + +I  ++k+ + e
  EFC36155.1 26 TLMITLCSKHKRSE 39
                68********9865 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.53
         PPR  15 kleeAlelfkeMk 27 
                 ++ee + l++eM 
  EFC36155.1 150 NFEEGMTLLHEMN 162
                 689*********5 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0056
         PPR   3 ynslIsgycknGkleeAlelf 23 
                  +++++ y k+ ++++A+e+ 
  EFC36155.1 207 LTTMVNFYNKCEDYDKAIEIT 227
                 69****************985 PP

  == domain 4  score: 17.5 bits;  conditional E-value: 3.2e-06
         PPR   2 tynslIsgycknGkleeAlelfkeMkekGi 31 
                 +yn+lI++y  + +l  A+e++ eM++ +i
  EFC36155.1 239 SYNCLIQSYIGKSDLNRAIEMLAEMQQQNI 268
                 8************************99775 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.032
         PPR   2 tynslIsgycknGkleeAlelf 23 
                 t+++++ +++ + ++e  l+++
  EFC36155.1 274 TFTIILTACADSKNYEQGLKVL 295
                 9*****************9997 PP

  == domain 6  score: 17.1 bits;  conditional E-value: 4.5e-06
         PPR   3 ynslIsgycknGkleeAlelfkeMke 28 
                  n++I+ y k+ k+++A+elf+   +
  EFC36155.1 309 LNAMINFYNKCEKFDKAIELFESVTK 334
                 6********************98665 PP

  == domain 7  score: 18.8 bits;  conditional E-value: 1.3e-06
         PPR   2 tynslIsgycknGkleeAlelfkeMkekG 30 
                 +yn++I++y  +G+l  A+e++ eM+  +
  EFC36155.1 341 SYNCVIQSYIGKGDLNGAIEILAEMQHLN 369
                 8************************9876 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.12
         PPR   2 tynslIsgycknGkleeAlelfk 24 
                 t ++++ +++ + ++e  l++++
  EFC36155.1 376 TLTIILTACADSKNYEQGLKVLN 398
                 7799****************997 PP

  == domain 9  score: 15.4 bits;  conditional E-value: 1.6e-05
         PPR   4 nslIsgycknGkleeAlelfkeM 26 
                 +s+I+ y k+ k+++A+elf+  
  EFC36155.1 412 TSMINFYNKCEKFDKAIELFESV 434
                 8*******************975 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.38     4e+02       2      32 ..     157     187 ..     156     201 .. 0.75
   2 ?    2.1   0.0      0.19     2e+02      19      60 ..     208     247 ..     203     250 .. 0.79
   3 !   26.9   0.0   3.6e-09   3.8e-06       4      62 ..     228     284 ..     225     285 .. 0.89
   4 !   22.0   0.1   1.2e-07   0.00013       3      40 ..     260     297 ..     258     317 .. 0.81
   5 ?    4.6   0.2     0.033        35      15      60 ..     306     349 ..     303     352 .. 0.85
   6 !   18.3   0.0   1.8e-06    0.0018       2      45 ..     361     404 ..     360     409 .. 0.92
   7 ?    0.6   0.0      0.56   5.9e+02      19      56 ..     412     450 ..     406     452 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.38
       PPR_3   2 ilremerkgikldvvtYthLLtayanagnkk 32 
                 +l+em+++ ik+  + +++ Lt + +  ++k
  EFC36155.1 157 LLHEMNAQKIKIFDNLFISSLTFSLKKNKQK 187
                 89*********98888888888865555554 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.19
       PPR_3  19 thLLtayanagnkklalevlermkkkgikPtvvtyNailgvi 60 
                 t++ + y +  +++ a e+   +  +g+     +yN +++ +
  EFC36155.1 208 TTMVNFYNKCEDYDKAIEITRNVSSDGLDT--TSYNCLIQSY 247
                 666777778889999999999999999974..5899999877 PP

  == domain 3  score: 26.9 bits;  conditional E-value: 3.6e-09
       PPR_3   4 remerkgikldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvigg 62 
                 r++  +g  ld   Y+ L++ y+   ++++a e l++m+++ i+P   t+ +il ++ +
  EFC36155.1 228 RNVSSDG--LDTTSYNCLIQSYIGKSDLNRAIEMLAEMQQQNISPDSATFTIILTACAD 284
                 5555555..58899******************************************965 PP

  == domain 4  score: 22.0 bits;  conditional E-value: 1.2e-07
       PPR_3   3 lremerkgikldvvtYthLLtayanagnkklalevler 40 
                 l em++++i +d  t+t +Lta+a  +n++  l+vl  
  EFC36155.1 260 LAEMQQQNISPDSATFTIILTACADSKNYEQGLKVLSL 297
                 78*******************************99975 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.033
       PPR_3  15 vvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvi 60 
                 + + +++++ y +  + + a e +e + k+++     +yN +++ +
  EFC36155.1 306 IRMLNAMINFYNKCEKFDKAIELFESVTKDRVDT--TSYNCVIQSY 349
                 56789999999999******************85..5899988876 PP

  == domain 6  score: 18.3 bits;  conditional E-value: 1.8e-06
       PPR_3   2 ilremerkgikldvvtYthLLtayanagnkklalevlermkkkg 45 
                 il em+  +i +d  t t +Lta+a  +n++  l+vl+ + +++
  EFC36155.1 361 ILAEMQHLNISPDSATLTIILTACADSKNYEQGLKVLNIIGENK 404
                 899*********************************98877776 PP

  == domain 7  score: 0.6 bits;  conditional E-value: 0.56
       PPR_3  19 thLLtayanagnkklalevlermkkkgikPtv.vtyNai 56 
                 t++++ y +  + + a e +e + k+++  t    +N+i
  EFC36155.1 412 TSMINFYNKCEKFDKAIELFESVSKDRLDTTSsQLFNSI 450
                 788888999999999**********99975541346666 PP

>> PPR_long  Pentacotripeptide-repeat region of PRORP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.45   4.7e+02      51     118 ..      27      91 ..       9     131 .. 0.64
   2 !   27.5   0.3   1.7e-09   1.8e-06      48     183 ..     165     295 ..     142     305 .. 0.82
   3 !   20.2   0.0   2.9e-07    0.0003      92     182 ..     308     396 ..     305     402 .. 0.91
   4 ?    3.1   0.0     0.048        51      84     119 ..     402     437 ..     388     448 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.45
                 HHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHH..TT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHH CS
    PPR_long  51 vllylcskaeaaseskknkalargfevfeamka..kgvspnEatvtalarlaaakedgdlafelvkemek 118
                  ++ lcsk ++++  +++k +++  ++ ++ ++  +++++ +    a+  l +++e  d+  +lv+++ +
  EFC36155.1  27 LMITLCSKHKRSEV-ERRKYIDELKNIIHHFDEgsATIRTIDI---AISTL-VQEEGYDEVVTLVRKLGN 91 
                 57889998876654.4456777777777776652222222222...22222.345566666666666654 PP

  == domain 2  score: 27.5 bits;  conditional E-value: 1.7e-09
                 HHHHHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S---HHHHHHHHHHHHHTT-HHHHHH CS
    PPR_long  48 hynvllylcskaeaaseskknkalargfevfeamkakgvspnEatvtalarlaaakedgdlafelvkemekagvsPrLRsyaPaLaayckagdadkale 146
                 + +++ +l  ++  + + kk    ++  ++ ++m ++  ++n   +t+++    + ed d+a e+ +++++ g++    sy+ ++++y  + d+++a+e
  EFC36155.1 165 KIKIFDNLFISSL-TFSLKK--NKQKESRMICSMIEHSKTTNKVLLTTMVNFYNKCEDYDKAIEITRNVSSDGLDT--TSYNCLIQSYIGKSDLNRAIE 258
                 5555555555553.333333..34666788899999999***********************************97..5******************** PP

                 HHHHHHHCT----HHHHHHHHHHHHHTT-HHHHHHHH CS
    PPR_long 147 veehlkasgveleEaelaaLLkvsakagredkvYelL 183
                   + +++++++++ a ++ +L ++a+  + ++  ++L
  EFC36155.1 259 MLAEMQQQNISPDSATFTIILTACADSKNYEQGLKVL 295
                 *************************988777655555 PP

  == domain 3  score: 20.2 bits;  conditional E-value: 2.9e-07
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH-S---HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHHHHHHHHTT-HHHHHHH CS
    PPR_long  92 tvtalarlaaakedgdlafelvkemekagvsPrLRsyaPaLaayckagdadkaleveehlkasgveleEaelaaLLkvsakagredkvYel 182
                 ++ a++    + e +d+a el ++++k  v+    sy+ ++++y  +gd++ a+e+ + ++  +++++ a l+ +L ++a+  + ++  ++
  EFC36155.1 308 MLNAMINFYNKCEKFDKAIELFESVTKDRVDT--TSYNCVIQSYIGKGDLNGAIEILAEMQHLNISPDSATLTIILTACADSKNYEQGLKV 396
                 578999999999*************9999997..5*********************************************98877765555 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.048
                 TT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
    PPR_long  84 kgvspnEatvtalarlaaakedgdlafelvkemeka 119
                 ++ ++n  ++t+++    + e +d+a el ++++k 
  EFC36155.1 402 ENKTSNNHSITSMINFYNKCEKFDKAIELFESVSKD 437
                 556789999*****************9999887654 PP

>> PPR_1  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.86   9.1e+02       8      29 ..     205     226 ..     203     228 .. 0.85
   2 !   12.6   0.0   7.9e-05     0.084       6      34 .]     236     264 ..     235     264 .. 0.95
   3 ?    3.9   0.0     0.042        45       2      15 ..     267     280 ..     266     293 .. 0.90
   4 !    7.9   0.1    0.0024       2.5      10      31 ..     309     330 ..     303     332 .. 0.90
   5 !   12.3   0.0   9.8e-05       0.1       6      34 .]     338     366 ..     336     366 .. 0.95
   6 ?   -0.5   0.0      0.96     1e+03       2      15 ..     369     382 ..     368     397 .. 0.87
   7 !    6.0   0.0    0.0094       9.9      11      31 ..     412     432 ..     412     433 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.86
                 HHHHHHHHHHHHTS-HHHHHHH CS
       PPR_1   8 vTYNtLIdGlCkaGrvdeAfel 29 
                 v  +t+++ + k+ + d+A+e+
  EFC36155.1 205 VLLTTMVNFYNKCEDYDKAIEI 226
                 6679999999999******985 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 7.9e-05
                 -HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   6 dvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 d+ +YN+LI ++  + ++++A+e++ eM+
  EFC36155.1 236 DTTSYNCLIQSYIGKSDLNRAIEMLAEMQ 264
                 8899************************5 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.042
                 S----HHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLId 15 
                 +++Pd  T+++++ 
  EFC36155.1 267 NISPDSATFTIILT 280
                 799********975 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0024
                 HHHHHHHHHHTS-HHHHHHHHH CS
       PPR_1  10 YNtLIdGlCkaGrvdeAfelfd 31 
                  N +I+ + k+ + d+A+elf+
  EFC36155.1 309 LNAMINFYNKCEKFDKAIELFE 330
                 699******************8 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 9.8e-05
                 -HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   6 dvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 d+ +YN++I ++  +G+++ A+e++ eM+
  EFC36155.1 338 DTTSYNCVIQSYIGKGDLNGAIEILAEMQ 366
                 8899************************5 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 0.96
                 S----HHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLId 15 
                 +++Pd  T ++++ 
  EFC36155.1 369 NISPDSATLTIILT 382
                 689*******9975 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.0094
                 HHHHHHHHHTS-HHHHHHHHH CS
       PPR_1  11 NtLIdGlCkaGrvdeAfelfd 31 
                 +++I+ + k+ + d+A+elf+
  EFC36155.1 412 TSMINFYNKCEKFDKAIELFE 432
                 68999999************8 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.2     0.015        16      14      49 ..     127     161 ..     114     186 .. 0.69
   2 !   12.8   0.0    0.0001      0.11       3      79 ..     218     295 ..     216     298 .. 0.87
   3 !   11.0   0.0   0.00036      0.38       3      79 ..     320     397 ..     318     399 .. 0.84
   4 ?   -0.9   0.0       1.9     2e+03      37      49 ..     422     434 ..     404     450 .. 0.67

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.015
                 HHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  14 rllaaetespedayllAlclylngqykrAyellrka 49 
                  ll++++ s+++  ++A+cl++  ++++ ++ll+++
  EFC36155.1 127 VLLERKQVSLYAYNYYAQCLFKY-NFEEGMTLLHEM 161
                 45556666777777778888874.466666666655 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 0.0001
                 T-HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-H.HHHHHHHHHHHHTT-HHHHHHHH CS
      ANAPC3   3 nnyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnsksl.gcrylfAqcllkLkkyeeAiaaL 79 
                 ++y++Ai +   +  ++  +  +   l +++   ++ +rA+e l ++ ++n +   +   ++  ++ + k+ye+++++L
  EFC36155.1 218 EDYDKAIEITRNVS-SDGLDTTSYNCLIQSYIGKSDLNRAIEMLAEMqQQNISPDsATFTIILTACADSKNYEQGLKVL 295
                 7899*********9.999999999999********************76665555466667779999**********99 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00036
                 T-HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-H.HHHHHHHHHHHHTT-HHHHHHHH CS
      ANAPC3   3 nnyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnsksl.gcrylfAqcllkLkkyeeAiaaL 79 
                 +++++Ai l+e +  +++ +  +     +++   g+ + A+e+l ++  ln +   + + ++  ++ + k+ye+++++L
  EFC36155.1 320 EKFDKAIELFESVT-KDRVDTTSYNCVIQSYIGKGDLNGAIEILAEMqHLNISPDsATLTIILTACADSKNYEQGLKVL 397
                 67899999999999.7777777777789*******************666655445777788899************99 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 1.9
                 T-HHHHHHHHHCT CS
      ANAPC3  37 gqykrAyellrka 49 
                 +++++A+el+++ 
  EFC36155.1 422 EKFDKAIELFESV 434
                 4455555555444 PP

>> ATP13  Mitochondrial ATPase expression
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0       0.5   5.2e+02      77     104 ..     105     135 ..      96     141 .. 0.85
   2 ?    4.6   0.0     0.027        29      53      82 ..     203     232 ..     179     234 .. 0.78
   3 !    6.5   0.1     0.007       7.3      41      77 ..     260     295 ..     235     304 .. 0.73
   4 ?    4.7   0.0     0.025        27      53      82 ..     305     334 ..     297     336 .. 0.88
   5 !    9.0   0.0    0.0011       1.2      49      80 ..     369     400 ..     338     410 .. 0.85
   6 ?    3.8   0.2     0.047        49      54     100 ..     408     453 ..     402     455 .] 0.82

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.5
       ATP13  77 vdkfskkYpe...ielkkefWeellewaiil 104
                 + k+ ++Yp+   ++++k++++ lle+ +++
  EFC36155.1 105 ILKVLSSYPNdfeLDIAKHIFSVLLERKQVS 135
                 55788999999999**********9987765 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.027
       ATP13  53 tselLkaivssfsynneiesAlklvdkfsk 82 
                 +  lL+++v+ + +++++++A+++  ++s+
  EFC36155.1 203 NKVLLTTMVNFYNKCEDYDKAIEITRNVSS 232
                 4568999*****************999876 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.007
       ATP13  41 etkvksdsplyPtselLkaivssfsynneiesAlklv 77 
                  ++++ +  + P+s++ + i+++ +  +++e++lk++
  EFC36155.1 260 LAEMQ-QQNISPDSATFTIILTACADSKNYEQGLKVL 295
                 45555.45678***********************997 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.025
       ATP13  53 tselLkaivssfsynneiesAlklvdkfsk 82 
                 t ++L a+++ + +++++++A++l ++++k
  EFC36155.1 305 TIRMLNAMINFYNKCEKFDKAIELFESVTK 334
                 8899*******************9998875 PP

  == domain 5  score: 9.0 bits;  conditional E-value: 0.0011
       ATP13  49 plyPtselLkaivssfsynneiesAlklvdkf 80 
                  + P+s++L+ i+++ +  +++e++lk+++ +
  EFC36155.1 369 NISPDSATLTIILTACADSKNYEQGLKVLNII 400
                 468*************************9865 PP

  == domain 6  score: 3.8 bits;  conditional E-value: 0.047
       ATP13  54 selLkaivssfsynneiesAlklvdkfskkYpeielkkefWeellew 100
                 ++ ++++++ + +++++++A++l +++sk       + ++++++l+w
  EFC36155.1 408 NHSITSMINFYNKCEKFDKAIELFESVSKDRL-DTTSSQLFNSILYW 453
                 56789999*******************99876.55566777777777 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1      0.02        21      11      22 ..     214     225 ..     212     227 .. 0.84
   2 ?   -0.6   0.0       1.3   1.4e+03       4      22 ..     240     258 ..     238     262 .. 0.83
   3 !    9.5   0.0   0.00084      0.89       5      25 ..     310     330 ..     306     334 .. 0.84
   4 ?   -2.9   0.0       6.8   7.2e+03      10      22 ..     348     360 ..     342     360 .. 0.80
   5 !    8.2   0.0    0.0021       2.2       9      25 ..     416     432 ..     412     434 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.02
                 HHHTT-HHHHHH CS
       TPR_1  11 yfklgkydeAle 22 
                 y k ++yd+A+e
  EFC36155.1 214 YNKCEDYDKAIE 225
                 889999999997 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.3
                 HHHHHHHHHHTT-HHHHHH CS
       TPR_1   4 lynlGnayfklgkydeAle 22 
                 ++ l + y  + +++ A+e
  EFC36155.1 240 YNCLIQSYIGKSDLNRAIE 258
                 8888899999999999998 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00084
                 HHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyye 25 
                 + + n y k +k+d+A+e +e
  EFC36155.1 310 NAMINFYNKCEKFDKAIELFE 330
                 666788*************98 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 6.8
                 HHHHTT-HHHHHH CS
       TPR_1  10 ayfklgkydeAle 22 
                  y  +g+++ A+e
  EFC36155.1 348 SYIGKGDLNGAIE 360
                 6888999999997 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.0021
                 HHHHHTT-HHHHHHHHH CS
       TPR_1   9 nayfklgkydeAleyye 25 
                 n y k +k+d+A+e +e
  EFC36155.1 416 NFYNKCEKFDKAIELFE 432
                 6799**********998 PP

>> FANCM-MHF_bd  FANCM to MHF binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.2   5.1e-05     0.054      21     115 ..     158     252 ..     147     253 .. 0.78
   2 !    9.6   0.0   0.00089      0.94      46     115 ..     284     354 ..     254     355 .. 0.75
   3 ?    1.3   0.0      0.33   3.5e+02      72      96 ..     412     436 ..     387     452 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 5.1e-05
  FANCM-MHF_bd  21 eeseeikeptlkrsqFlslekeeeeesekeksesreLSLsewrvWQnkplPthlvdHSdrckhFievmelielmreeee.ecsyelelkpylkked 115
                    ++ + +++++    F+s  +  + +++k+k+++   S+ e++   nk l t++v+  ++c+++ + +e+  ++ ++   ++sy+  +++y+ k d
    EFC36155.1 158 LHEMNAQKIKIFDNLFISSLT-FSLKKNKQKESRMICSMIEHSKTTNKVLLTTMVNFYNKCEDYDKAIEITRNVSSDGLdTTSYNCLIQSYIGKSD 252
                   445555666666666665443.344567777888889**********************************99988764499*********98877 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00089
  FANCM-MHF_bd  46 esekeksesreLSLsewrvWQnkplPthlvdHSdrckhFievmelielm.reeeeecsyelelkpylkked 115
                    s++ +++ + LSL +     +  +   +++  ++c++F + +el e + ++  +++sy+  +++y+ k+d
    EFC36155.1 284 DSKNYEQGLKVLSLKNKIKHITIRMLNAMINFYNKCEKFDKAIELFESVtKDRVDTTSYNCVIQSYIGKGD 354
                   45666777778888777666677777889999***************87255567***********99887 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.33
  FANCM-MHF_bd  72 thlvdHSdrckhFievmelielmre 96 
                   t++++  ++c++F + +el e + +
    EFC36155.1 412 TSMINFYNKCEKFDKAIELFESVSK 436
                   7889999************998765 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.34   3.6e+02       6      29 ..     209     232 ..     205     242 .. 0.82
   2 ?    3.7   0.0      0.14   1.4e+02       6      40 ..     242     278 ..     238     282 .. 0.78
   3 ?    6.1   0.0     0.022        24       5      30 ..     310     335 ..     306     343 .. 0.84
   4 ?    1.7   0.0      0.57     6e+02      10      41 ..     348     381 ..     341     384 .. 0.76
   5 ?    3.8   0.0      0.12   1.3e+02       9      29 ..     416     436 ..     413     443 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.34
      TPR_14   6 alaeallalGdpdeAiallrrala 29 
                  ++ ++   +d+d+Ai++ r + +
  EFC36155.1 209 TMVNFYNKCEDYDKAIEITRNVSS 232
                 57889999*********9987766 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.14
      TPR_14   6 alaeallalGdpdeAiallrralala..Pddaeawll 40 
                 +l + +    d+ +Ai++l ++ +++  Pd+a++ + 
  EFC36155.1 242 CLIQSYIGKSDLNRAIEMLAEMQQQNisPDSATFTII 278
                 5677777778999*********997555999987765 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.022
      TPR_14   5 lalaeallalGdpdeAiallrralal 30 
                  a+  ++   +++d+Ai+l++ + ++
  EFC36155.1 310 NAMINFYNKCEKFDKAIELFESVTKD 335
                 57889999*************98776 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.57
      TPR_14  10 allalGdpdeAiallrra..lalaPddaeawlll 41 
                  +   Gd+ +Ai++l ++  l   Pd+a++ + l
  EFC36155.1 348 SYIGKGDLNGAIEILAEMqhLNISPDSATLTIIL 381
                 5677899**********84444679999887655 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.12
      TPR_14   9 eallalGdpdeAiallrrala 29 
                  ++   +++d+Ai+l++ + +
  EFC36155.1 416 NFYNKCEKFDKAIELFESVSK 436
                 6888999*********98865 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0       1.5   1.6e+03      23      37 ..     134     148 ..     101     150 .. 0.71
   2 ?   -0.4   0.0       1.7   1.8e+03      31      47 ..     210     226 ..     201     242 .. 0.73
   3 ?    4.8   0.0     0.039        41       6      55 ..     219     267 ..     216     275 .. 0.77
   4 ?    3.1   0.1      0.13   1.4e+02       5      27 ..     251     275 ..     243     297 .. 0.59
   5 ?    1.8   0.0      0.33   3.5e+02      31      57 ..     312     338 ..     304     343 .. 0.74
   6 !    8.6   0.0    0.0025       2.6       3      55 ..     351     404 ..     349     410 .. 0.85
   7 ?    0.6   0.0      0.78   8.3e+02       6      18 ..     423     435 ..     414     445 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 1.5
      TPR_19  23 knaearllLAealla 37 
                  +++a  ++A++l++
  EFC36155.1 134 VSLYAYNYYAQCLFK 148
                 356677778888876 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.7
      TPR_19  31 LAeallalgqldeAeal 47 
                 +++ + +  ++d+A+++
  EFC36155.1 210 MVNFYNKCEDYDKAIEI 226
                 66667777777777776 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.039
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeed 55 
                 dy+ A+++ +++ + d  +      L++ ++   +l+ A+++L++ ++++
  EFC36155.1 219 DYDKAIEITRNV-SSDGLDTTSYNCLIQSYIGKSDLNRAIEMLAEMQQQN 267
                 888888888887.3334466666678999999999999999999988876 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.13
      TPR_19   5 gdyaeAlalleqalqe..dpknaea 27 
                  d+ +A+++l+++ q+  +p++a  
  EFC36155.1 251 SDLNRAIEMLAEMQQQniSPDSATF 275
                 4666777777776655555655555 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.33
      TPR_19  31 LAeallalgqldeAealLdalpeedpd 57 
                 +++ + +   +d+A++l + + ++  d
  EFC36155.1 312 MINFYNKCEKFDKAIELFESVTKDRVD 338
                 667777778888888888888777666 PP

  == domain 6  score: 8.6 bits;  conditional E-value: 0.0025
      TPR_19   3 aegdyaeAlalleqalqe..dpknaearllLAeallalgqldeAealLdalpeed 55 
                   gd+  A+++l+++     +p++a + +    a+  ++++++  ++L+ ++e +
  EFC36155.1 351 GKGDLNGAIEILAEMQHLniSPDSATLTI-ILTACADSKNYEQGLKVLNIIGENK 404
                 679***********8333559*9999999.99999*************9998876 PP

  == domain 7  score: 0.6 bits;  conditional E-value: 0.78
      TPR_19   6 dyaeAlalleqal 18 
                 +++ A++l+e++ 
  EFC36155.1 423 KFDKAIELFESVS 435
                 5677777777763 PP

>> Mistic  Membrane-integrating protein Mistic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.032        34      16      40 ..     207     231 ..     202     236 .. 0.88
   2 !    8.1   0.1    0.0024       2.5      16      41 ..     309     334 ..     305     341 .. 0.87
   3 !    6.4   0.1    0.0081       8.5      13      41 ..     408     436 ..     406     443 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.032
                 HHHHHHH--SSS-SS-SS-SHHHHH CS
      Mistic  16 ldafieLYNeseedkpliefeeevl 40 
                 l +++++YN+ e+  + ie + +v 
  EFC36155.1 207 LTTMVNFYNKCEDYDKAIEITRNVS 231
                 678**********999999998875 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0024
                 HHHHHHH--SSS-SS-SS-SHHHHHH CS
      Mistic  16 ldafieLYNeseedkpliefeeevle 41 
                 l+a+i++YN+ e+  + ie+ e v +
  EFC36155.1 309 LNAMINFYNKCEKFDKAIELFESVTK 334
                 89***********9999999888776 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0081
                 THHHHHHHHH--SSS-SS-SS-SHHHHHH CS
      Mistic  13 negldafieLYNeseedkpliefeeevle 41 
                 n ++ ++i++YN+ e+  + ie+ e v +
  EFC36155.1 408 NHSITSMINFYNKCEKFDKAIELFESVSK 436
                 567789**********9999999887765 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.059        63       5      20 ..     210     225 ..     206     229 .. 0.83
   2 !    6.5   0.0     0.009       9.5       7      24 ..     314     331 ..     309     338 .. 0.80
   3 ?    5.8   0.0     0.015        16       9      24 ..     418     433 ..     416     446 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.059
       TPR_7   5 LarlysrlGdyeeAie 20 
                 + + y ++ dy++Aie
  EFC36155.1 210 MVNFYNKCEDYDKAIE 225
                 56789999*******9 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.009
       TPR_7   7 rlysrlGdyeeAielyeq 24 
                 + y ++ ++++Aiel+e 
  EFC36155.1 314 NFYNKCEKFDKAIELFES 331
                 6688899*********97 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.015
       TPR_7   9 ysrlGdyeeAielyeq 24 
                 y ++ ++++Aiel+e 
  EFC36155.1 418 YNKCEKFDKAIELFES 433
                 678899********97 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.075        79       8      25 ..     209     226 ..     202     262 .. 0.81
   2 !    8.3   0.0    0.0026       2.7       3      30 ..     306     333 ..     304     362 .. 0.75
   3 ?    3.4   0.0      0.09        95       9      28 ..     414     433 ..     408     438 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.075
      TPR_12   8 nlaavlrrlgrydeAlel 25 
                  + +++++ ++yd+A+e+
  EFC36155.1 209 TMVNFYNKCEDYDKAIEI 226
                 578899999999999886 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0026
      TPR_12   3 atalnnlaavlrrlgrydeAlellekal 30 
                  ++ln + +++++ +++d+A+el+e + 
  EFC36155.1 306 IRMLNAMINFYNKCEKFDKAIELFESVT 333
                 679999******************9875 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.09
      TPR_12   9 laavlrrlgrydeAlellek 28 
                 + +++++ +++d+A+el+e 
  EFC36155.1 414 MINFYNKCEKFDKAIELFES 433
                 66899999999999999986 PP

>> SNAP  Soluble NSF attachment protein, SNAP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.21   2.2e+02     150     189 ..     199     238 ..     193     255 .. 0.73
   2 !    7.0   0.2    0.0033       3.5     137     196 ..     287     347 ..     239     355 .. 0.72
   3 !    7.6   0.1    0.0021       2.3     138     190 ..     390     443 ..     354     449 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.21
                 -HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHTTSS-T CS
        SNAP 150 akalankcllkvAelsaelekyekAieiyekvakkslenn 189
                 +k++ + +l  + +++ + e+y+kAiei  +v ++ l+  
  EFC36155.1 199 SKTTNKVLLTTMVNFYNKCEDYDKAIEITRNVSSDGLDTT 238
                 44444445556678999999******99999988777665 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0033
                 HHHHHHHHHHHTT.-HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHTTSS-TTTGGGHH CS
        SNAP 137 aYekAaelyeqee.akalankcllkvAelsaelekyekAieiyekvakkslennllkysvk 196
                 +Ye+  ++ +  +  k  +  +l  + +++ + ek++kAie++e+v k+ ++       ++
  EFC36155.1 287 NYEQGLKVLSLKNkIKHITIRMLNAMINFYNKCEKFDKAIELFESVTKDRVDTTSYNCVIQ 347
                 5777777777666455555566666678889999**************9998776665555 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0021
                 HHHHHHHHHHTT.-HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHTTSS-TT CS
        SNAP 138 YekAaelyeqee.akalankcllkvAelsaelekyekAieiyekvakkslennl 190
                 Ye+  ++ +  +  k++ n+    + +++ + ek++kAie++e+v k+ l+   
  EFC36155.1 390 YEQGLKVLNIIGeNKTSNNHSITSMINFYNKCEKFDKAIELFESVSKDRLDTTS 443
                 5666665555442555666667778899999****************9998765 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.092        97       9      22 ..     212     225 ..     206     229 .. 0.79
   2 ?   -1.3   0.0       3.3   3.5e+03      10      24 ..     246     260 ..     245     262 .. 0.76
   3 ?    4.1   0.0     0.065        68      10      27 ..     315     332 ..     307     334 .. 0.78
   4 ?    1.5   0.0      0.43   4.5e+02      10      24 ..     348     362 ..     347     364 .. 0.87
   5 ?    3.4   0.1      0.11   1.1e+02      10      26 ..     417     433 ..     414     436 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.092
                 HHHHHTT-HHHHHH CS
       TPR_8   9 siylklgdyeeAke 22 
                 + y k +dy++A+e
  EFC36155.1 212 NFYNKCEDYDKAIE 225
                 56888999999987 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 3.3
                 HHHHTT-HHHHHHHH CS
       TPR_8  10 iylklgdyeeAkeyy 24 
                  y+ + d++ A+e +
  EFC36155.1 246 SYIGKSDLNRAIEML 260
                 588888888998876 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.065
                 HHHHTT-HHHHHHHHHHH CS
       TPR_8  10 iylklgdyeeAkeyyeka 27 
                  y k +++++A+e +e +
  EFC36155.1 315 FYNKCEKFDKAIELFESV 332
                 578888888888888865 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.43
                 HHHHTT-HHHHHHHH CS
       TPR_8  10 iylklgdyeeAkeyy 24 
                  y+ +gd++ A+e +
  EFC36155.1 348 SYIGKGDLNGAIEIL 362
                 69**********987 PP

  == domain 5  score: 3.4 bits;  conditional E-value: 0.11
                 HHHHTT-HHHHHHHHHH CS
       TPR_8  10 iylklgdyeeAkeyyek 26 
                  y k +++++A+e +e 
  EFC36155.1 417 FYNKCEKFDKAIELFES 433
                 58899999999999986 PP

>> INTS5_N  Integrator complex subunit 5 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.89   9.3e+02      65      95 ..      25      60 ..       5      96 .. 0.60
   2 ?    7.0   0.2    0.0036       3.8     126     174 ..     200     247 ..     180     253 .. 0.82
   3 ?    5.9   0.2    0.0079       8.3     116     167 ..     297     345 ..     252     349 .. 0.85
   4 ?    2.9   0.1     0.067        71     125     168 ..     405     448 ..     393     452 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.89
     INTS5_N 65 e.....pilkesqinaeldeaieeiqtvleelveen 95
                        +k++ ++ e  ++i e+++++++++e +
  EFC36155.1 25 AtlmitLCSKHKRSEVERRKYIDELKNIIHHFDEGS 60
                044443334444455555666666666666666544 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0036
     INTS5_N 126 satnp..lnellqlwmscevvellldisskclsslisqesdacvdaLLets 174
                  +tn+  l+++++++ +ce  ++ ++i+++++s  ++++s++c   L++++
  EFC36155.1 200 KTTNKvlLTTMVNFYNKCEDYDKAIEITRNVSSDGLDTTSYNC---LIQSY 247
                 22333679***********************************...66665 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0079
     INTS5_N 116 skkagrrgvssatnp.lnellqlwmscevvellldisskclsslisqesdacv 167
                  k++ +    + t   ln++++++ +ce  ++ +++ +++ +  ++++s++cv
  EFC36155.1 297 LKNKIK----HITIRmLNAMINFYNKCEKFDKAIELFESVTKDRVDTTSYNCV 345
                 444333....33333499**********************************8 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.067
     INTS5_N 125 ssatnplnellqlwmscevvellldisskclsslisqesdacvd 168
                  s++ +++ +++++ +ce  ++ +++ +++++  ++++s +  +
  EFC36155.1 405 TSNNHSITSMINFYNKCEKFDKAIELFESVSKDRLDTTSSQLFN 448
                 34445799**************9999999999888888777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (455 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1042  (0.0581181); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 2627.10
//
Query:       EFC36156.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.18   11.2   0.2       0.27   10.7   0.2    1.2  1  PIH1      PIH1 N-terminal domain


Domain annotation for each model (and alignments):
>> PIH1  PIH1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.2   1.5e-05      0.27      32      53 ..     122     143 ..      95     145 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 1.5e-05
        PIH1  32 pgfvvktsvkgeeKvFiNvcss 53 
                  g +++t+ +g++K+F+ ++++
  EFC36156.1 122 FGKCIRTCCNGNNKCFVGIANA 143
                 489**************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       574  (0.0320152); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.31s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1032.78
//
Query:       EFC36157.1  [L=265]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      0.008   15.8   0.0      0.014   15.0   0.0    1.3  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   7.8e-07     0.014      78     172 ..      29     126 ..      10     138 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 7.8e-07
  Guanylate_cyc  78 laelaLdmlealeevaveskeglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagkiqv...seetyellkeeqfeltergeve 169
                     +e +L++ + l+++  +s+++++  +Gi t    +g iG  + + y v G  v  A ++   g++ +++v   s  t +     qf ++ ++++e
     EFC36157.1  29 SIEASLKISKILDNILGKSEKKVSYCIGIFTDMAYIGNIGnHSLRCYSVVGPIVSNARKLAIFGHTLDCKVlvdSG-TLSPVVISQFVIRPIDRIE 123
                    578899999999****************************666777***************999998888765444.4443335999999999999 PP

  Guanylate_cyc 170 vkG 172
                    ++ 
     EFC36157.1 124 MEV 126
                    984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (265 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       962  (0.0536561); expected 358.6 (0.02)
Passed bias filter:                      566  (0.031569); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1679.95
//
Query:       EFC36158.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-18   66.8   5.3    2.8e-18   65.8   5.3    1.6  1  Ribosomal_L38e  Ribosomal L38e protein family
  ------ inclusion threshold ------
       0.03   13.5   0.5      0.038   13.2   0.5    1.3  1  Glyco_hydro_59  Glycosyl hydrolase family 59
       0.44    9.6   1.6        7.7    5.6   0.4    2.3  2  LisH_2          LisH


Domain annotation for each model (and alignments):
>> Ribosomal_L38e  Ribosomal L38e protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.8   5.3   4.7e-22   2.8e-18       1      68 [.     128     199 ..     128     200 .. 0.94

  Alignments for each domain:
  == domain 1  score: 65.8 bits;  conditional E-value: 4.7e-22
  Ribosomal_L38e   1 PkeikdiKeFLeiar.rkDaksvkikknk...kdntKfKvRcsryLYTLvvkdkekaeklkqsLppglkvke 68 
                     Pk+i ++KeFL++a   k+  s++++k+k   ++++KfK+R+++yLYTL++k+k ka++l+++Lpp+lk++ 
      EFC36158.1 128 PKQILNVKEFLALAVaAKEKGSITLYKSKdrkNRSYKFKLRTRQYLYTLKMKNKVKAQQLEKALPPTLKKSY 199
                     9************98578888********99999***********************************976 PP

>> Glyco_hydro_59  Glycosyl hydrolase family 59
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.5   6.4e-06     0.038      71     163 ..      16     105 ..       2     191 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 6.4e-06
  Glyco_hydro_59  71 verGyefwlakeAkkrnpdikldileWgaPgwlkksaekasektaeylkswlkgakktygldidyiaglrnekeydkdyvktlrkaLdkngyk 163
                     v+   + +  keA k + d+ ++i +   Pg++  ++  +s+++ +++ ++ + + k+y+ ++d   + +ne++   + + +l +a  k+  +
      EFC36158.1  16 VNEYLQQQKEKEAVKAQSDLSFSIWKRINPGYVVPTEIYKSTTKDTFVPQYSDPIDKSYNRMLDKA-AQWNEED--LKTFGKLTSATPKAAIS 105
                     55555556679**********************988889999999********************9.9999998..55556666555555555 PP

>> LisH_2  LisH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0    0.0094        56       4      12 ..      15      23 ..      14      24 .. 0.86
   2 ?    5.6   0.4    0.0013       7.7       9      19 ..     167     177 ..     167     177 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.0094
      LisH_2  4 LvaeYLqsq 12
                +v+eYLq q
  EFC36158.1 15 IVNEYLQQQ 23
                89*****87 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0013
      LisH_2   9 LqsqgYnYTLS 19 
                 L++ +Y YTL+
  EFC36158.1 167 LRTRQYLYTLK 177
                 899******96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1641  (0.0915277); expected 358.6 (0.02)
Passed bias filter:                      520  (0.0290033); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1345.42
//
Query:       EFC36159.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.2e-22   75.9   0.4    6.2e-07   29.1   0.1    5.2  5  NHL           NHL repeat
    8.8e-05   22.2   0.1       0.17   11.4   0.0    2.2  2  SGL           SMP-30/Gluconolactonase/LRE-like region
     0.0076   16.1   0.4        1.6    8.6   0.1    2.9  3  FlgD_ig       FlgD Ig-like domain
  ------ inclusion threshold ------
      0.026   14.5   0.0        6.2    6.7   0.0    2.8  3  Phytase-like  Esterase-like activity of phytase


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   1.5e-07   0.00067       1      27 [.      54      79 ..      54      80 .. 0.94
   2 !   29.1   0.1   1.4e-10   6.2e-07       1      24 [.     111     134 ..     111     137 .. 0.92
   3 !    9.1   0.0   0.00031       1.4       1      23 [.     170     193 ..     170     197 .. 0.90
   4 !   11.3   0.0   6.4e-05      0.29       4      27 ..     231     254 ..     230     255 .. 0.89
   5 ?   -0.6   0.0      0.36   1.6e+03       1       9 [.     284     292 ..     284     293 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 1.5e-07
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +nyP+G a+  nGd+++aDs nhr+++
  EFC36159.1 54 LNYPSGMAM-YNGDLLIADSFNHRIRK 79
                79*******.6**************86 PP

  == domain 2  score: 29.1 bits;  conditional E-value: 1.4e-10
                 BSSEEEEEEETTTEEEEEECCCTE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhr 24 
                 +n+P+Gvav snGd+y+aD  nh 
  EFC36159.1 111 LNFPSGVAVHSNGDVYIADKSNHV 134
                 79********************95 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00031
                 BSSEEEEEEE.TTTEEEEEECCCT CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenh 23 
                 +n+P+ +av+ s+ +++++D++n+
  EFC36159.1 170 LNSPQYLAVNsSTAEVIISDTNNN 193
                 689999****************98 PP

  == domain 4  score: 11.3 bits;  conditional E-value: 6.4e-05
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P G+ ++s G+i+ aDs+nhr+++
  EFC36159.1 231 PKGIIINSIGEIIFADSRNHRIRK 254
                 888889999*************97 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 0.36
                 BSSEEEEEE CS
         NHL   1 fnyPhGvav 9  
                 +nyP++va+
  EFC36159.1 284 LNYPNSVAL 292
                 79*****96 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.0   3.8e-05      0.17     131     218 ..      45     147 ..      40     156 .. 0.81
   2 !    8.7   0.0   0.00025       1.1     140     218 ..     177     263 ..     162     270 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3.8e-05
         SGL 131 ddltipNGlawspdgktlYl.....aDsltrkiwaydvdaeggklsnrrvf..adlkkge........gepDGlavDaeGnvwvAvwgggkvvrfdpd. 213
                 d+l  +N+l   p g  +Y      aDs +++i +++++++g  +s    +    ++ ++        + p G+av ++G v++A  +++ +++++   
  EFC36159.1  45 DGLISTNALLNYPSGMAMYNgdlliADSFNHRIRKVSFSSSGV-ISTIAGIgsSSFSGDGglainaelNFPSGVAVHSNGDVYIADKSNHVIRKVSALn 142
                 7788888888889999999888888*************98887.77666554444444448999998777*****************999999998765 PP

         SGL 214 Gklie 218
                 Gk+++
  EFC36159.1 143 GKITT 147
                 77654 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00025
         SGL 140 awspdgktlYlaDsltrkiwaydvdaeggklsnrrvf..adlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 a+++ +  +++ D+ ++ i ++ ++ +  ++        + +++g+       +p G+++ + G+++ A  +++++++++++Gk+++
  EFC36159.1 177 AVNSSTAEVIISDTNNNVIRKVYLNGTIVTIAGVYGSsgYSGDNGNavsaklFNPKGIIINSIGEIIFADSRNHRIRKISKNGKITT 263
                 66666777777777777777777766655555544442244444447777765699***************************9876 PP

>> FlgD_ig  FlgD Ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.1   4.8e+03      25      42 ..      65      82 ..      61      88 .. 0.79
   2 !    4.4   0.0    0.0075        34      23      42 ..     121     140 ..      96     144 .. 0.72
   3 !    8.6   0.1   0.00036       1.6      17      42 ..     174     200 ..     158     203 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.1
                EEEEEE-SS--EEEEEEE CS
     FlgD_ig 25 vtvtikDasGevVrtidl 42
                + + i D+ ++ +r++++
  EFC36159.1 65 GDLLIADSFNHRIRKVSF 82
                567899999999999876 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0075
                 EEEEEEEE-SS--EEEEEEE CS
     FlgD_ig  23 devtvtikDasGevVrtidl 42 
                 +++ v i D+s++v+r++++
  EFC36159.1 121 SNGDVYIADKSNHVIRKVSA 140
                 5679************9875 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00036
                 E..ESSSEEEEEEEE-SS--EEEEEEE CS
     FlgD_ig  17 e.lpeaadevtvtikDasGevVrtidl 42 
                 + l+ ++++++v i D +++v+r++ l
  EFC36159.1 174 QyLAVNSSTAEVIISDTNNNVIRKVYL 200
                 3689999****************9865 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.21   9.3e+02      75      97 ..      62      83 ..      59      97 .. 0.79
   2 ?    4.4   0.0     0.007        31      72     103 ..     116     148 ..      69     172 .. 0.82
   3 ?    6.7   0.0    0.0014       6.2      57     101 ..     218     262 ..     167     276 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.21
  Phytase-like 75 vapdgtfwvssEggpfilefdad 97
                  +  +g++++++ ++++i++++ +
    EFC36159.1 62 M-YNGDLLIADSFNHRIRKVSFS 83
                  5.6899***********998854 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.007
  Phytase-like  72 giavapdgtfwvssEggpfilefdad.Gkllre 103
                   g+av ++g++++++  ++ i++++a  Gk+++ 
    EFC36159.1 116 GVAVHSNGDVYIADKSNHVIRKVSALnGKITTI 148
                   8999********************666998654 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0014
  Phytase-like  57 dpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdadGkll 101
                    ++g+++  k ++p gi +++ g++++++ ++++i++++++Gk++
    EFC36159.1 218 GDNGNAVSAKLFNPKGIIINSIGEIIFADSRNHRIRKISKNGKIT 262
                   456888877888999***************************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       571  (0.0318478); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 1944.33
//
Query:       EFC36160.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.022   14.9   0.3      0.032   14.3   0.3    1.3  1  P_gingi_FimA  Major fimbrial subunit protein (FimA)
      0.075   13.8   0.1       0.11   13.3   0.1    1.3  1  DKNYY         DKNYY family


Domain annotation for each model (and alignments):
>> P_gingi_FimA  Major fimbrial subunit protein (FimA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.3   3.6e-06     0.032      27      80 ..     152     203 ..     125     213 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3.6e-06
                   TE-SEEEEEEEETTSCCEEEEEEEEESTTCCEEEEEEEEEEEEEECSE.EEEEEE CS
  P_gingi_FimA  27 akInsLtvyVFnekgelvskkkelkvsgdgseaiknvttiadipvtsg.ekkvvv 80 
                   +  n L vyVF+++g + s+  +l+vs++ ++++ +v+ +     ++   + +v 
    EFC36160.1 152 TPLNQLFVYVFDANGVVNSNGFNLAVSNQPTSSGLVVVGT---LSNTKrVNSIVS 203
                   56699*****************************999322...222333444444 PP

>> DKNYY  DKNYY family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   1.2e-05      0.11      78     126 ..      82     138 ..      25     152 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.2e-05
       DKNYY  78 kekekkkkikkadsktFeildsgya........kDknnvYykgkkiegadaksFkvi 126
                 k+ +++++ + a++++Fe+ ds y+        k++ +vYy+  k+e ++++ ++ +
  EFC36160.1  82 KQVYQTQVSNGAQINSFEYFDSLYIdetwhrvlKGNSSVYYNCTKLELIVPNKWNET 138
                 444578888999********9998888888899****************99999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       695  (0.038764); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1550.68
//
Query:       EFC36161.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.8e-25   87.6   0.9    1.1e-24   87.3   0.9    1.0  1  Pkinase      Protein kinase domain
    1.1e-14   54.4   0.3    1.3e-14   54.1   0.3    1.0  1  Pkinase_Tyr  Protein tyrosine kinase
  ------ inclusion threshold ------
       0.15   12.0   0.0       0.16   11.8   0.0    1.1  1  APH          Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.3   0.9   1.8e-28   1.1e-24       1     120 [.      25     150 ..      25     153 .. 0.91

  Alignments for each domain:
  == domain 1  score: 87.3 bits;  conditional E-value: 1.8e-28
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHS.CTTB--EEEEEEE.....SSEEEEEEE--TTEBHHHHHHHH CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfee.....kdelylvleyveggeladllerk 92 
                 ye+++ +G+G++G+V++a+++e++++vA+Kki +  + +++  k++lrE+kil++l  ++n+v+ly+ +        +++y+v+e+++ + l ++++ +
  EFC36161.1  25 YEVKKVIGQGAYGVVVSAYDRERKQEVAIKKIFNIFEHDREYqKRILREVKILRHLGeCENVVQLYDLVLPpsfeeFNDVYIVMEFMDSN-LRQMIKSN 122
                 7899***************************9987777666559*************9*********7655555549***********55.******** PP

                 SS--HHHHHHHHHHHHHHHHHHHHTTEE CS
     Pkinase  93 gslseeeakkiakqilegleylHskgii 120
                 + l++++++ +++++l+gl+ +Hs++i+
  EFC36161.1 123 QELTDQNIQYFLYHLLRGLKTIHSANIL 150
                 *************************996 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.1   0.3   2.2e-18   1.3e-14       2     124 ..      26     149 ..      25     154 .. 0.88

  Alignments for each domain:
  == domain 1  score: 54.1 bits;  conditional E-value: 2.2e-18
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEEST..TSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE.....SSSSEEEEEE--TTEBHHHH CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlke..eateeekeelleeakimkkl.khpnivkllgvct.....keepllivteyvkgGdLlkf 91 
                  e++k +G+Ga+G Vv+++ +    +++++Va+K++ +  e+++e ++++l+e+ki+++l + +n+v+l+ +++     + + ++iv+e++++ +L+++
   EFC36161.1  26 EVKKVIGQGAYGVVVSAYDR----ERKQEVAIKKIFNifEHDREYQKRILREVKILRHLgECENVVQLYDLVLppsfeEFNDVYIVMEFMDS-NLRQM 118
                  57899************999....8999******966235555569**************************9876655556********86.8**** PP

                  HHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTE CS
  Pkinase_Tyr  92 LrkkekekltlkdllsfalqvAkGmeyLeskkl 124
                  ++++  ++lt +++  f +++ +G++ ++s ++
   EFC36161.1 119 IKSN--QELTDQNIQYFLYHLLRGLKTIHSANI 149
                  **98..99******************9999886 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   2.8e-05      0.16      30     108 ..      62     147 ..      24     159 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.8e-05
                 TT.S-HHHHHHHHHHHHHHHHTT-B--B-CTTBS-EEETTE..EEEEEE----EE-SS.....HHHHHHHHHHHHHHHHHHCCHHCH CS
         APH  30 pa.raaeeirrevallrlLakagvpvPevlagdtddeeigl..lfalieyvpgrsllr.....klsaaqlpellealgeflaalhqv 108
                 +  +++ +i rev++lr+L + +  v +++++     ++++  ++ ++e+++   +       +l+++ ++ +l+ l + l+ +h++
  EFC36161.1  62 HDrEYQKRILREVKILRHLGECEN-VVQLYDLVLPPSFEEFndVYIVMEFMDSNLRQMiksnqELTDQNIQYFLYHLLRGLKTIHSA 147
                 33479999**************77.88****************99999999988777788889899999999999999999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       736  (0.0410508); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1148.65
//
Query:       EFC36162.1  [L=777]
Description: rho GTPase activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.9e-30  103.9   3.6    1.5e-29  102.8   0.7    2.9  3  RhoGAP    RhoGAP domain
  ------ inclusion threshold ------
       0.22   11.2  23.6       0.44   10.2  18.5    2.9  2  BAR_3     BAR domain of APPL family


Domain annotation for each model (and alignments):
>> RhoGAP  RhoGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0      0.57   5.1e+03     113     135 ..     304     326 ..     298     328 .. 0.84
   2 !  102.8   0.7   1.7e-33   1.5e-29       1     147 [.     374     528 ..     374     532 .. 0.91
   3 ?   -0.5   0.0      0.11   9.6e+02      99     142 ..     646     689 ..     606     698 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.57
                 HHHHHHHHHHHTHHHH---HHHH CS
      RhoGAP 113 yLlehLkrvaenskenkMtaknL 135
                 +L++ L +v ++++e +M+   L
  EFC36162.1 304 ALFQQLDNVVKKAEEAQMQEGHL 326
                 69999999999999999987766 PP

  == domain 2  score: 102.8 bits;  conditional E-value: 1.7e-33
                 BHHHHHHHHHHHHHTTTSTTTTTS-S-HHHHHHHHHHHHHTGGGCTTTTTSCHHHHHHHHHHHHHHSSSTTTTGGHHHHHH.H..HHTS.....SSHHH CS
      RhoGAP   1 PiivekcvefiekrgldtegiyRvsgskarvkelreafdkgkavdsdleeedvhavaslLKrfLrelpepLltkelyeeli.e..aaks.....edeee 91 
                 P+ ++++ + i++ gld+eg++Rv+ +++ +k+l   ++ gk+ +   +++ v ++a++LK+f rel+epL+t+++++e+i +  + ++       +e 
  EFC36162.1 374 PPSIKQLFDLIRAFGLDQEGVFRVNSDEQYMKKLIIDIEMGKEIQYVNKSYFVPSIAGVLKLFVRELQEPLMTFDAFQEIIlNpdM-QTlpsesSVKEG 471
                 78899***************************************999**********************************44541.224544466777 PP

                 HHHHHHHHHT.TS-HHHHHHHHHHHHHHHHHHHTHHHH---HHHHHHHHHHHHHT-T CS
      RhoGAP  92 rlealkelle.kLPkenrdtLryLlehLkrvaenskenkMtaknLaivfaPtLlrpk 147
                 ++++lke ++ k+P + + +L+ L+++L++va+++++nkM a+nL+++f+ +L+rp+
  EFC36162.1 472 QVSKLKEFINtKVPIHYQVVLYELCKLLNEVAQHEDKNKMHANNLSLIFSMNLFRPR 528
                 7*********9999999999***********************************96 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.11
                 HHTTS-HHHHHHHHHHHHHHHHHHHTHHHH---HHHHHHHHHHH CS
      RhoGAP  99 llekLPkenrdtLryLlehLkrvaenskenkMtaknLaivfaPt 142
                 ++++LP  n + +    +hL r  ++ ++   + +n+++++aP+
  EFC36162.1 646 TFSDLPTLNSSEIIQPKRHLDRNVKYDHKHVTSNHNVSLILAPS 689
                 55566666666666666899999999999999999999999997 PP

>> BAR_3  BAR domain of APPL family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2  18.5     5e-05      0.44      25     217 ..     110     316 ..     101     329 .. 0.64
   2 ?   -2.8   0.2      0.47   4.2e+03      78     105 ..     534     561 ..     487     590 .. 0.52

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 5e-05
       BAR_3  25 eelekklkkllKlckrlieagkaysaaqkqfaqsLrelkkeskgdeetdesLkkfsellqelenehtilldqaqrsikkpLekFrkedlkevkekkkkF 123
                 +++ ++ kk  K+  +l ++ k++ +  + +a+  ++++ ++k+++e++e+L+kf+  l+ ++   ++ + ++++   k Le  ++++ k +++ + k+
  EFC36162.1 110 QDTMEFYKKAEKKLLDLKKSSKKMIEKEHDIATLFNDFAPKFKKNKEMSETLRKFGGNLKSTSTLLSQAMMKLDEFKDKTLE--MRDEGKTISKFRSKY 206
                 5666777788888888889999999999999999999999999999999999999988877655444444444433333332..222333444445555 PP

       BAR_3 124 dkesekleaaleknaqls..........kkkke......seleeadnelkatrkkfhqasldyvlqinelqerkkfeiletllsfmqaqltFfhqGyel 206
                 d +++++e+      +++          +++ e      ++ +++++  k   k+ ++a  dy +++     ++ +e ++ l sf++a + +f  G+ l
  EFC36162.1 207 DSARSDYESFKLETPRVNpdkdgftnkpNEHGEydpqyiERTKKVEEDFKLIAKNLNNAYSDYHNELDFQLLKRDTEYFSDLKSFIYAYYCYFSTGMAL 305
                 555555555444333333111111000022111111111233344445555566777778899999999999*************************** PP

       BAR_3 207 fkdlepfmkeL 217
                 f++l+++ k+ 
  EFC36162.1 306 FQQLDNVVKKA 316
                 ******98864 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.47
       BAR_3  78 kfsellqelenehtilldqaqrsikkpL 105
                 ++++ +++++     l+++++  + ++L
  EFC36162.1 534 QLAQNVKHMSYVTCLLIENFDTLFEASL 561
                 3333334444444444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (777 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1911  (0.106587); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.80u 0.31s 00:00:01.11 Elapsed: 00:00:00.48
# Mc/sec: 4832.43
//
Query:       EFC36163.1  [L=215]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.1e-24   84.8   0.0      1e-23   84.1   0.0    1.3  1  Pkinase      Protein kinase domain
      2e-05   24.0   0.1    2.5e-05   23.7   0.1    1.4  1  Pkinase_Tyr  Protein tyrosine kinase
  ------ inclusion threshold ------
        1.6    8.3   3.9        3.4    7.3   0.2    2.7  3  STAR_dimer   Homodimerisation region of STAR domain protein


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.1   0.0   1.7e-27     1e-23     136     264 .]       2     154 ..       1     154 [. 0.80

  Alignments for each domain:
  == domain 1  score: 84.1 bits;  conditional E-value: 1.7e-27
                 EEEE-SGTTSEESSSSCS...BCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHHHHHS....S-STTTSSHHHHHHHHHHTHHHHHHHCT....S CS
     Pkinase 136 elKitDFGlakelesssk...ltsfvgtseYlAPEvl.keneyskkvDvWslGvilyelltg....kppfsgekgkekvekeldqlekilkilg....e 222
                 e+K +DFGl++ +es+++    t++v+t++Y++PE+l    + +k+ D+WslG+i++e+l +    k +f+        ++ l+ql  il++ g    e
  EFC36163.1   2 EIKYCDFGLSRGIESDTNpkmSTTYVATRWYRSPELLlMWDQAGKPLDIWSLGCIFAEMLDKppkrKVLFP-------GKNYLNQLDLILDVTGtptdE 93 
                 5899***********99999999**************677888****************864111144555.......445777777788888764331 PP

                 HH...HHHTTS......................-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 223 tkeklpeasei......................seeakdllkkllkkdpkkRltaeellqhpyl 264
                    +++   +                       ++ a+dll+k+l+ dp kR+t+ee+l+hpyl
  EFC36163.1  94 ---ETRGCAKAkkymktlpkkqkqnfkdifphaNPLAIDLLEKMLTFDPLKRITVEEALAHPYL 154
                 ...33222222455677888888999************************************97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.1   4.2e-09   2.5e-05     142     201 ..       3      63 ..       1     149 [. 0.83

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 4.2e-09
                  EEE-STTTHEETTTSSEEEETTSSTSGGGGS.-HHHHHH.SEEEHHHHHHHHHHHHHHHHTT CS
  Pkinase_Tyr 142 vkisDfGLardiekddeyvkkeeaklpvkWm.apEslke.kkftsksDvWsfGvllwEiftl 201
                  +k +DfGL+r i ++d+  k +++ +  +W+ +pE l    +  +  D+Ws G +  E++ +
   EFC36163.1   3 IKYCDFGLSRGI-ESDTNPKMSTTYVATRWYrSPELLLMwDQAGKPLDIWSLGCIFAEMLDK 63 
                  899*********.55555667778899999879**976615678889************984 PP

>> STAR_dimer  Homodimerisation region of STAR domain protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.55   3.3e+03       6      12 ..      74      80 ..      72      80 .. 0.83
   2 ?    7.3   0.2   0.00057       3.4      16      30 ..     110     124 ..     102     128 .. 0.89
   3 ?    1.1   0.1     0.048   2.9e+02      29      38 ..     183     192 ..     180     199 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.55
  STAR_dimer  6 pdYLaqL 12
                 +YL qL
  EFC36163.1 74 KNYLNQL 80
                69****9 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.00057
  STAR_dimer  16 KKqlaafpnvftHle 30 
                 KKq+++f ++f+H +
  EFC36163.1 110 KKQKQNFKDIFPHAN 124
                 9************65 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.048
  STAR_dimer  29 lerLLdeEIs 38 
                 +++LL eEI+
  EFC36163.1 183 IKKLLHEEIV 192
                 589******5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       473  (0.0263818); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1324.25
//
Query:       EFC36164.1  [L=784]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-42  142.8  25.4    9.1e-15   54.1   0.1    9.7  8  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.025   14.6   0.5       0.15   12.0   0.3    2.5  2  DUF1160   Protein of unknown function (DUF1160)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.1   0.1     1e-18   9.1e-15       1      49 []     235     283 ..     235     283 .. 0.98
   2 !   28.2   0.2   1.3e-10   1.2e-06       3      47 ..     262     306 ..     262     308 .. 0.96
   3 !   30.9   0.3   1.8e-11   1.6e-07       1      46 [.     343     387 ..     343     389 .. 0.92
   4 !   30.4   0.1   2.6e-11   2.3e-07       1      49 []     392     441 ..     392     468 .. 0.87
   5 !   10.1   0.6   5.6e-05       0.5      19      47 ..     463     492 ..     446     509 .. 0.62
   6 !   12.8   0.5   8.1e-06     0.073       1      32 [.     558     589 ..     540     591 .. 0.87
   7 ?   -1.7   0.0      0.29   2.6e+03      21      35 ..     629     643 ..     627     660 .. 0.80
   8 !    5.7   0.1    0.0013        12       5      37 ..     690     749 ..     663     763 .. 0.74

  Alignments for each domain:
  == domain 1  score: 54.1 bits;  conditional E-value: 1e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D E+v++++k+ngs lky+s+eL+n+keiv+ Av ++ +a+ +as+e++
  EFC36164.1 235 DPEFVTKYLKTNGSQLKYVSKELRNNKEIVMVAVSNYVDAIQFASDEIK 283
                 89*********************************************96 PP

  == domain 2  score: 28.2 bits;  conditional E-value: 1.3e-10
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 Eiv+ av+++  a++++s+e+k D  +++ ++++++  ++++se 
  EFC36164.1 262 EIVMVAVSNYVDAIQFASDEIKDDDIFMKDILQIHPLTIRFCSER 306
                 9******************************************96 PP

  == domain 3  score: 30.9 bits;  conditional E-value: 1.8e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 D+E +l  +++ +s ++ ls++LknD++i+l+Avk n  ++s +++
  EFC36164.1 343 DKEYALSMIDNTCSTYHSLSDNLKNDRDICLRAVK-NRLSISQIPP 387
                 99*********************************.7777777775 PP

  == domain 4  score: 30.4 bits;  conditional E-value: 2.6e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsyaseeLr 49 
                 D+Ei+l av+  ++ +  +se+Lk+D++++l A+k++  ++   ++ee+r
  EFC36164.1 392 DKEIALTAVRLSSYEYLSISERLKRDRDVALIALKNSTqSIVHKVPEEIR 441
                 9**********777777799***************776345566666665 PP

  == domain 5  score: 10.1 bits;  conditional E-value: 5.6e-05
     DUF4116  19 lseeL.knDkeivlkAvkqngtalsyasee 47 
                 +seeL +nD+e++lk + ++++++  + e 
  EFC36164.1 463 ASEELkTNDRELILKFLVNHSYIYHSLNEA 492
                 566665556666666655555555444433 PP

  == domain 6  score: 12.8 bits;  conditional E-value: 8.1e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 ++ ++le+++  +  + +++++L +D ++++k
  EFC36164.1 558 NKNFILEILEYRPIDISKIDHSLLCDEDVLMK 589
                 68899999999999999999999999999998 PP

  == domain 7  score: -1.7 bits;  conditional E-value: 0.29
     DUF4116  21 eeLknDkeivlkAvk 35 
                 ++Lk+  e+v+ A+ 
  EFC36164.1 629 DSLKQTPELVKIAIT 643
                 688999999999885 PP

  == domain 8  score: 5.7 bits;  conditional E-value: 0.0013
     DUF4116   5 vleavkkngs............................alkylseeLknDkeivlkAvkqn 37 
                 +l+++k++++                            ++k +++++    e+v++A++ n
  EFC36164.1 690 ILQILKSYPKlyglgmfglgwrqrqdldfinlsireptNFKEIPPSFL-TSELVIEAIQHN 749
                 555666665555556666666666666666666666668999999998.899999999976 PP

>> DUF1160  Protein of unknown function (DUF1160)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.3   1.7e-05      0.15      67     107 ..     244     285 ..     236     295 .. 0.86
   2 ?   -3.1   0.0      0.82   7.3e+03      53      77 ..     597     621 ..     585     623 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.7e-05
     DUF1160  67 kLtkkQidylvkqvyenekiisi.lqkfvdeqrLtddeisdl 107
                 k + +Q+ y+ k++ +n++i+++ + ++vd  ++ +dei+d 
  EFC36164.1 244 KTNGSQLKYVSKELRNNKEIVMVaVSNYVDAIQFASDEIKDD 285
                 56779**************9887479*************985 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.82
     DUF1160  53 vediyeiveavdgikLtkkQidylv 77 
                  e +  + +  +g k+++k i++lv
  EFC36164.1 597 EELMNVLPNLQNGFKMSAKMIEHLV 621
                 4455555566788899999999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (784 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.30s 00:00:01.04 Elapsed: 00:00:00.48
# Mc/sec: 4942.58
//
Query:       EFC36165.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.062   13.2   2.0      0.097   12.5   2.0    1.3  1  Exonuc_VIII  Enterobacterial exodeoxyribonuclease VIII
      0.081   13.4   0.2        6.4    7.3   0.0    2.4  2  NPV_P10      Nucleopolyhedrovirus P10 protein
       0.18   11.6   3.5       0.52   10.2   0.2    2.6  3  LapA_dom     Lipopolysaccharide assembly protein A domain
        1.2    8.3  11.0        1.9    7.5  11.0    1.5  1  Tmemb_cc2    Predicted transmembrane and coiled-coil 2 protei


Domain annotation for each model (and alignments):
>> Exonuc_VIII  Enterobacterial exodeoxyribonuclease VIII
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   2.0   2.2e-05     0.097      73     178 ..      55     154 ..       7     165 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.2e-05
  Exonuc_VIII  73 fsdryqlakdsmtwelkpGvtlpsseaaaadrahivdGvdtetGevledieenlgnesnspaqatapapellvvatqelrirvlaqyiGeekylthvd 170
                  f+++y+    + t +  p v+l +++ aa++  h vd  ++ +  + +++++   ++     qa     el  +  q+    vl + i + +  +hv 
   EFC36165.1  55 FCKYYN---TNHTNTASPAVALSTTHGAASNAFHHVDSFTSYNTHQHKQQHQQHDQNVADYHQAMNILRELNQIRHQNY---VLNKQISHLQEYVHVK 146
                  455554...5789999***************9999****9999999888888887788888899999999988887764...6666666666677887 PP

  Exonuc_VIII 171 alqkkeil 178
                   ++  + +
   EFC36165.1 147 ESNTNNSA 154
                  66666555 PP

>> NPV_P10  Nucleopolyhedrovirus P10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.0    0.0014       6.4       6      45 ..     122     161 ..     115     169 .. 0.87
   2 ?    3.7   0.1     0.019        84      29      47 ..     184     202 ..     173     205 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0014
     NPV_P10   6 LlvIradikavddkVdalqqqvddvqenlpdvtelnekLd 45 
                 L +Ir+    ++++++ lq+ v+  ++n ++  +l++ +d
  EFC36165.1 122 LNQIRHQNYVLNKQISHLQEYVHVKESNTNNSANLSSWMD 161
                 679999999*************999999999888887777 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.019
     NPV_P10  29 dvqenlpdvtelnekLdaq 47 
                 d+++n ++v+el+e+L ++
  EFC36165.1 184 DLEKNRKKVKELKEELSKL 202
                 5667777777777776655 PP

>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.89     4e+03      41      58 ..      94     111 ..      90     117 .. 0.71
   2 ?    1.6   0.1     0.053   2.4e+02      44      61 ..     124     141 ..     110     144 .. 0.79
   3 ?   10.2   0.2   0.00012      0.52      29      63 ..     167     199 ..     165     202 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.89
    LapA_dom  41 sylrlrrelrrlkkkikk 58 
                    +++ ++++ ++ +++
  EFC36165.1  94 NTHQHKQQHQQHDQNVAD 111
                 456888888888887776 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.053
    LapA_dom  44 rlrrelrrlkkkikklek 61 
                 + r ++  l+k+i +l++
  EFC36165.1 124 QIRHQNYVLNKQISHLQE 141
                 788888889******998 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00012
    LapA_dom  29 iGallgwllslwsylrlrrelrrlkkkikklekel 63 
                 +G+l g +++++  + lr+ l + +kk+k+l++el
  EFC36165.1 167 FGLLCGSVVFVL--IALRMDLEKNRKKVKELKEEL 199
                 677778777776..799999999999999999997 PP

>> Tmemb_cc2  Predicted transmembrane and coiled-coil 2 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5  11.0   0.00043       1.9     185     252 ..      64     147 ..       4     208 .. 0.62

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00043
   Tmemb_cc2 185 sssssve.................sssadsnsnseestasasksaesesqeklekileelqeikeeqerleeelerlkeqlkkel 252
                  +++s +                   s  s  +++++++++++ ++  + ++  +il+el++i++++  l++++ +l+e ++   
  EFC36165.1  64 TNTASPAvalstthgaasnafhhvD-SFTSYNTHQHKQQHQQHDQNVADYHQAMNILRELNQIRHQNYVLNKQISHLQEYVHVKE 147
                 2222211222222333322222211.11122222222222234455666778889**********************99877544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2761  (0.153996); expected 358.6 (0.02)
Passed bias filter:                      791  (0.0441185); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 1411.38
//
Query:       EFC36166.1  [L=492]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (492 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       404  (0.0225333); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 3069.92
//
Query:       EFC36167.1  [L=363]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (363 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       524  (0.0292264); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 2068.23
//
Query:       EFC36168.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.016   15.3   0.0       0.03   14.5   0.0    1.4  1  ZoocinA_TRD  Target recognition domain of lytic exoenzyme
      0.062   13.2   0.1       0.11   12.4   0.1    1.3  1  FdhE         Protein involved in formate dehydrogenase format
      0.081   13.3   5.8        1.7    9.0   1.2    2.5  2  DUF2039      Uncharacterized conserved protein (DUF2039)
        6.7    6.7   9.2        3.1    7.7   4.0    2.8  3  Baculo_IE-1  Baculovirus immediate-early protein (IE-0)


Domain annotation for each model (and alignments):
>> ZoocinA_TRD  Target recognition domain of lytic exoenzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   6.6e-06      0.03      55     102 ..     356     407 .]     341     407 .] 0.81

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6.6e-06
  ZoocinA_TRD  55 lkvGdyfvfnPksvlsvee...pi.ygvaGltfakvkfaegesiWlsveskk 102
                   k+Gd f+f+ ++ +sv++   pi   +  + f++vk+a+ +s+W++v++k+
   EFC36168.1 356 QKKGDVFIFDRACCNSVDRfnnPIkIEIDEFFFKDVKLANNDSLWIYVNDKQ 407
                  699********999998752225524678999****************9986 PP

>> FdhE  Protein involved in formate dehydrogenase formation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   2.4e-05      0.11      48     206 ..      15     166 ..       6     170 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.4e-05
                 HHCS---..--HHHHHHHHHTT--TT-HHHHHHH-TTHHHHHHHHHT--S-SSHHHHHHHHHHHH--HHHHHHHHHHHHTT-GGGS-GGGHHHHHHHHH CS
        FdhE  48 vlaaekplaldaeaieraqehgmpplaakalerdeawqelLqallealkeelpealrealerlrkadaeelealadallageleavdaakavfvaaAlq 146
                 ++  +++ ++d +++++a++h  p+++++++e+++a+ +  + ll++ ++++   l+++ ++  +++++e ++ a++  + + ++ ++ k +       
  EFC36168.1  15 II--KQEEMPDVNTLSSASSHDLPVINKQETEASDALSSFNNILLDQEAHDVLLGLTQLTNHDDESNQDESKESATRTTSTSTTSISNGKNLTYCSV-- 109
                 44..233347899999******************************999999998888888888888888888888888888888888888776654.. PP

                 HHHHHHHHT--TTSSS-.-TT-SS-TTT---EEEEEEE-------EEEEEETTT.--EEE- CS
        FdhE 147 vvwtklaaaldakalaelaeekglCPvCgsaPvasvvriggeaeglRylhCslC.eteWhv 206
                   + +  ++++ ++     +++++   Cg++P  +   i + +eg   + Cs+C + +W++
  EFC36168.1 110 --CRRSSEQVNFHKNYT-INTNNYKNYCGTFPHFADQ-IPKPKEGESHVVCSTCyNKQWRF 166
                 ..456667776666644.4457888899****87753.55669***********4567876 PP

>> DUF2039  Uncharacterized conserved protein (DUF2039)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   1.0    0.0042        19      15      46 ..      93     124 ..      78     136 .. 0.70
   2 ?    9.0   1.2   0.00039       1.7      21      54 ..     145     177 ..     124     187 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0042
     DUF2039  15 dkskktkkieklavegvCerCkdkieWkvkyk 46 
                 +++++ ++ ++l+  +vC+r  ++++++++y 
  EFC36168.1  93 TSTTSISNGKNLTYCSVCRRSSEQVNFHKNYT 124
                 2344555666779999**********999985 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00039
     DUF2039  21 kkieklavegvCerCkdkieWkvkykkYkaltkk 54 
                  k ++ + + vC++C +k +W++  +kY + +++
  EFC36168.1 145 PKPKEGESHVVCSTCYNK-QWRFANGKYDPHKDR 177
                 4445568899******98.9********998764 PP

>> Baculo_IE-1  Baculovirus immediate-early protein (IE-0)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   4.0    0.0007       3.1      56     119 ..     104     168 ..      68     174 .. 0.67
   2 ?   -0.6   0.0      0.27   1.2e+03      14      52 ..     312     350 ..     303     366 .. 0.61
   3 ?   -2.6   0.0         1   4.7e+03      29      43 ..     360     374 ..     349     385 .. 0.63

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0007
  Baculo_IE-1  56 eksleviklinervqvlnvflek.klyqcniced.tsaeerflkPneccGykicnlcyanlwkfst 119
                    +++v ++ +e+v+  + ++ + + y+ n c       ++  kP+e   + +c  cy + w+f++
   EFC36168.1 104 LTYCSVCRRSSEQVNFHKNYTINtNNYK-NYCGTfPHFADQIPKPKEGESHVVCSTCYNKQWRFAN 168
                  4566666666666666655554314444.45543145567778*********************97 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.27
  Baculo_IE-1  14 vyiflpylkqlrkilklfvndycckklvkklkaaldell 52 
                  +  +++y+k+++ il+     +  ++   ++ ++l++l+
   EFC36168.1 312 ITFLISYMKRFNGILEDIYTTKIATHHCPETVEQLRDLV 350
                  445678999999988766555544444444444444333 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1
  Baculo_IE-1  29 klfvndy.cckklvkk 43 
                  ++f  d  cc+++  +
   EFC36168.1 360 DVFIFDRaCCNSV-DR 374
                  5787775155554.43 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1452  (0.0809861); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 2331.64
//
Query:       EFC36169.1  [L=730]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-34  118.9   0.1    9.8e-34  116.0   0.0    2.7  2  DSPc             Dual specificity phosphatase, catalytic doma
    2.2e-16   59.6  86.4    3.8e-06   27.2   3.1   10.6 13  LRR_4            Leucine Rich repeats (2 copies)
    1.9e-13   49.9  67.8    7.2e-06   25.7   5.5    9.8 10  LRR_8            Leucine rich repeat
    0.00089   18.9   0.0     0.0019   17.8   0.0    1.5  1  Y_phosphatase    Protein-tyrosine phosphatase
     0.0036   17.2  49.0        0.6   10.3   3.0   10.7 10  LRR_6            Leucine Rich repeat
     0.0066   16.7   1.1      0.024   14.9   0.2    2.4  2  Init_tRNA_PT     Rit1 DUSP-like domain
  ------ inclusion threshold ------
      0.026   15.0  57.3        1.7    9.5   0.6   13.3 12  LRR_1            Leucine Rich Repeat
      0.057   13.5   0.0       0.14   12.2   0.0    1.7  1  PTPlike_phytase  Inositol hexakisphosphate


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       1.9   4.3e+03      50      68 ..     138     156 ..      98     181 .. 0.58
   2 !  116.0   0.0   4.4e-37   9.8e-34       1     131 [.     594     722 ..     594     724 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.9
                 STTSCCGGGHHHHHHHHHH CS
        DSPc  50 ehetkiskyleeavefidk 68 
                 + e+++   le++v+ +++
  EFC36169.1 138 NLENNLITSLENLVKELNE 156
                 3344444444443333333 PP

  == domain 2  score: 116.0 bits;  conditional E-value: 4.4e-37
                 EEEEECCHHC.HHHHHHHTCSEEEEESSSSSECECCTTTTSEEEEECCESSTTSCCGGGHHHHHHHHHHHHHTT-EEEEEESSSSSHHHHHHHHHHHHH CS
        DSPc   1 lylgskstas.lallsklgitlvinvtkevpnanalkkseieklripvedehetkiskyleeavefidkakqkgkkvlVHCqaGisRSatliiaYlmkt 98 
                 lylg + +a+ +  ++ lgit+v+nv++           +++++++ ++d+  +++ +++++ v+fi++a ++++++lVHC+aG+sRSa+++iaY mk+
  EFC36169.1 594 LYLGGNGSAQsKHNMKLLGITHVLNVAEGLIA---PYPFDFKYKKVELSDTLGEDLLPHIDACVKFIEEAIDSQGTILVHCKAGVSRSASMVIAYVMKK 689
                 79**9999999****************77765...55579*********************************************************** PP

                 HTSCHHHHHHHHHHHSTT-SSTHHHHHHHHHHH CS
        DSPc  99 knlslneayeflkerrpaispnagfirqLleye 131
                 ++lsl+ea +++ke+r++i+pn  f++qL +y 
  EFC36169.1 690 FKLSLDEATQMVKEKRSQICPNGAFVKQLEDYG 722
                 *****************************9986 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.1    0.0061        14      11      36 ..      57      88 ..      54      98 .. 0.76
   2 !   19.9   8.8   3.1e-07    0.0007       1      42 [.     110     150 ..     110     156 .. 0.86
   3 !    8.7   1.9    0.0011       2.5       3      40 ..     167     206 ..     162     211 .. 0.83
   4 !    8.7   0.4     0.001       2.3      20      34 ..     295     313 ..     273     319 .. 0.65
   5 ?    5.4   0.4     0.012        27       1      15 [.     327     341 ..     327     352 .. 0.76
   6 !    9.9   7.3   0.00044      0.99       3      33 ..     355     384 ..     353     411 .. 0.85
   7 ?   -1.8   1.1       2.1   4.7e+03      21      34 ..     419     432 ..     395     447 .. 0.66
   8 ?    0.9   2.9      0.31   6.9e+02       6      39 ..     424     461 ..     421     467 .. 0.69
   9 !   14.6   2.3   1.5e-05     0.033       3      40 ..     448     487 ..     446     490 .. 0.82
  10 !   24.0   2.8   1.7e-08   3.8e-05       1      40 [.     471     510 ..     471     518 .. 0.89
  11 !   27.2   3.1   1.7e-09   3.8e-06       1      40 [.     494     532 ..     494     535 .. 0.83
  12 !   16.7   4.9   3.3e-06    0.0073       1      33 [.     519     553 ..     519     560 .. 0.86
  13 ?   -2.3   0.0       3.2   7.1e+03       3      11 ..     591     599 ..     591     600 .. 0.58

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0061
                S---E-S-......HHH.-TT--EEE-.-S--- CS
       LRR_4 11 Nqltdipl......lek.lpnLkeLdLsgNnli 36
                N+lt+ ++      ++k l+  ++L LsgN ++
  EFC36169.1 57 NKLTSSQFgsscrnFQKcLDRVEHLELSGN-QL 88
                788887777665555577899999999999.65 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 3.1e-07
                 SS--EEE--SS---E-S-HHH-TT..--EEE-.-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpn..LkeLdLsgNnlitdldeL 42 
                 ++L++LdLsnN+++ +p    + +  Lk L+L +Nnlit+l++L
  EFC36169.1 110 KSLTFLDLSNNMIKNFPI--ECLSipLKILNL-ENNLITSLENL 150
                 68************9555..466666******.988*****987 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0011
                 --EEE--SS---E-S-..HH.H-TT--EEE-.-S-----GG CS
       LRR_4   3 LevLdLsnNqltdipl..le.klpnLkeLdLsgNnlitdld 40 
                 Le+L++s N ++ +p+  +  k+++  ++dL +N ++++l+
  EFC36169.1 167 LESLNISKNLIQHFPFyiIVkKFKKVDSIDLGEN-PLQSLS 206
                 99**********9888753346*********556.998885 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.001
                 H....H-TT--EEE-.-S- CS
       LRR_4  20 e....klpnLkeLdLsgNn 34 
                       lpn ++LdLs N 
  EFC36169.1 295 PvelfDLPNIQHLDLSKNK 313
                 044545*********9994 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.012
                 SS--EEE--SS---E CS
       LRR_4   1 pnLevLdLsnNqltd 15 
                 p+ ++L+Lsn+ql +
  EFC36169.1 327 PSITSLNLSNCQLDE 341
                 678999999999984 PP

  == domain 6  score: 9.9 bits;  conditional E-value: 0.00044
                 --EEE--SS---E-S-HHH-TT--EEE-.-S CS
       LRR_4   3 LevLdLsnNqltdiplleklpnLkeLdLsgN 33 
                  ++L L+nN++++i     +pn  +++Ls+N
  EFC36169.1 355 IRKLILHNNNIKEILIED-FPNIISINLSNN 384
                 699**********65555.*********888 PP

  == domain 7  score: -1.8 bits;  conditional E-value: 2.1
                 H-TT--EEE-.-S- CS
       LRR_4  21 klpnLkeLdLsgNn 34 
                 + ++L  L+L +Nn
  EFC36169.1 419 GYKDLLNLSLIRNN 432
                 45667777776663 PP

  == domain 8  score: 0.9 bits;  conditional E-value: 0.31
                 EE--..SS---E-S-....HHH-TT--EEE-.-S-----G CS
       LRR_4   6 LdLs..nNqltdipl....leklpnLkeLdLsgNnlitdl 39 
                 L+Ls   N+l  +p     l+k+ + ++L+Lsg  +++++
  EFC36169.1 424 LNLSliRNNLE-VPKigisLSKFSSIRSLTLSGL-FLSSI 461
                 44444478877.4444556668*********995.56666 PP

  == domain 9  score: 14.6 bits;  conditional E-value: 1.5e-05
                 --EEE--SS---E-S-.HH..H-TT--EEE-.-S-----GG CS
       LRR_4   3 LevLdLsnNqltdipl.le..klpnLkeLdLsgNnlitdld 40 
                  ++L Ls+  l++ipl ++  ++pn + LdLs+N  i+d++
  EFC36169.1 448 IRSLTLSGLFLSSIPLdINqsNMPNIEFLDLSEN-EIGDFS 487
                 688999988899****855657*********999.888875 PP

  == domain 10  score: 24.0 bits;  conditional E-value: 1.7e-08
                 SS--EEE--SS---E-S-.HHH-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl.leklpnLkeLdLsgNnlitdld 40 
                 pn e+LdLs N + d+++ l  l+ Lk++dLs+N +i+++d
  EFC36169.1 471 PNIEFLDLSENEIGDFSSnLLMLTELKSIDLSFN-NISTID 510
                 799************9999888*********888.776764 PP

  == domain 11  score: 27.2 bits;  conditional E-value: 1.7e-09
                 SS--EEE--SS---E-S-HH...H-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpnLkeLdLsgNnlitdld 40 
                 + L+++dLs N++++i+      +l++L++LdLs+Nn    l+
  EFC36169.1 494 TELKSIDLSFNNISTIDVDDemcNLTKLTSLDLSHNN----LT 532
                 67****************444666************4....33 PP

  == domain 12  score: 16.7 bits;  conditional E-value: 3.3e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgN 33 
                 ++L++LdLs+N+lt++p    l  lp+   L+L  N
  EFC36169.1 519 TKLTSLDLSHNNLTEFPIdlvLL-LPSIDILSLEYN 553
                 79****************96555.*********777 PP

  == domain 13  score: -2.3 bits;  conditional E-value: 3.2
                 --EEE--SS CS
       LRR_4   3 LevLdLsnN 11 
                 Le L+L++N
  EFC36169.1 591 LERLYLGGN 599
                 566666655 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.012        27      24      37 ..      75      88 ..      59      97 .. 0.71
   2 !    7.3   4.6    0.0017       3.9      23      61 .]     107     144 ..      91     144 .. 0.70
   3 !    8.8   6.6   0.00061       1.4       2      41 ..     111     148 ..     110     156 .. 0.90
   4 !    8.2   0.5   0.00092       2.1       3      43 ..     167     208 ..     165     212 .. 0.87
   5 !   17.5   2.7   1.2e-06    0.0026      17      61 .]     295     339 ..     284     339 .. 0.87
   6 !    6.7   2.7    0.0028       6.2      26      59 ..     354     384 ..     343     386 .. 0.70
   7 ?    4.1   1.4     0.018        41      25      58 ..     421     455 ..     417     456 .. 0.89
   8 !   16.8   4.6   1.9e-06    0.0043       2      61 .]     447     506 ..     446     506 .. 0.90
   9 !   25.7   5.5   3.2e-09   7.2e-06       2      59 ..     495     553 ..     494     554 .. 0.85
  10 ?   -3.3   0.0       3.5   7.9e+03      51      59 ..     591     599 ..     590     600 .. 0.54

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.012
                -TT--EEE--SS-- CS
       LRR_8 24 lsnLkvLdLsnNll 37
                l ++++L+Ls N+l
  EFC36169.1 75 LDRVEHLELSGNQL 88
                55566666666665 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0017
                 T.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  23 g.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +  ++L+ LdLsnN ++ +  +++s    L+ L+L++N +
  EFC36169.1 107 QfAKSLTFLDLSNNMIKNFPIECLSIP--LKILNLENNLI 144
                 445889999999999999954444444..88899999876 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00061
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGG CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttls 41 
                 +Lt LdLsnN +++ + e+ +    Lk+L+L nNl+t+l+
  EFC36169.1 111 SLTFLDLSNNMIKNFPIECLS--IPLKILNLENNLITSLE 148
                 6899*****************..9*************996 PP

  == domain 4  score: 8.2 bits;  conditional E-value: 0.00092
                 -SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGG CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspg 43 
                 L+sL++s+N +++ +     + ++++ ++dL++N l++ls +
  EFC36169.1 167 LESLNISKNLIQHFPFYIIVKkFKKVDSIDLGENPLQSLSIN 208
                 899999999999999988877799999999999999999855 PP

  == domain 5  score: 17.5 bits;  conditional E-value: 1.2e-06
                 -TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  17 ddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsgNrL 61 
                 + e F  l+n ++LdLs N  l+    + ++  ps++sL+Ls+++L
  EFC36169.1 295 PVELFD-LPNIQHLDLSKNkHLNYSKMKQLVLSPSITSLNLSNCQL 339
                 555565.************99***********************98 PP

  == domain 6  score: 6.7 bits;  conditional E-value: 0.0028
                 T--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  26 nLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 + + L L nN+++ +    ++++p++ s++Ls+N
  EFC36169.1 354 SIRKLILHNNNIKEI---LIEDFPNIISINLSNN 384
                 566677777777777...5777777777777776 PP

  == domain 7  score: 4.1 bits;  conditional E-value: 0.018
                 TT--EEE--SS---G.GGGGGGTT--S-.EEE--S CS
       LRR_8  25 snLkvLdLsnNlltt.lspgafsgLpsLrsLdLsg 58 
                 + L  L+L +N+l++     ++s ++s+rsL+Lsg
  EFC36169.1 421 KDLLNLSLIRNNLEVpKIGISLSKFSSIRSLTLSG 455
                 78999*********99668**************97 PP

  == domain 8  score: 16.8 bits;  conditional E-value: 1.9e-06
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + +sL Ls   l+s++ +  ++ ++n + LdLs+N++  +s   +  L+ L+s+dLs N++
  EFC36169.1 447 SIRSLTLSGLFLSSIPLDINQSnMPNIEFLDLSENEIGDFS-SNLLMLTELKSIDLSFNNI 506
                 67899999999999999998888*****************9.6666789**********97 PP

  == domain 9  score: 25.7 bits;  conditional E-value: 3.2e-09
                 T-SEEE-TTS--SEE-..TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltsld..deaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +L+s+dLs+N+++ +d  de+ + l++L++LdLs+N+lt +  +    Lps++ L L++N
  EFC36169.1 495 ELKSIDLSFNNISTIDvdDEMCN-LTKLTSLDLSHNNLTEFPIDLVLLLPSIDILSLEYN 553
                 799********998762145555.*****************99999999****9999999 PP

  == domain 10  score: -3.3 bits;  conditional E-value: 3.5
                 -.EEE--SS CS
       LRR_8  51 LrsLdLsgN 59 
                 L+ L+L gN
  EFC36169.1 591 LERLYLGGN 599
                 455555555 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   8.6e-07    0.0019     153     215 ..     651     707 ..     643     718 .. 0.73

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 8.6e-07
                    HHHHHHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHHHHHHHHHHHHSEEEHHHHHHHHHTT CS
  Y_phosphatase 153 ksllklirkvekskeaksgpvvVhCsaGvgRtgtfvaldillqqleaeeevdvlqivkelrkq 215
                    ++ +k+i+++  s+    g ++VhC+aGv+R++++v + +++++++  +  +  q+vke r+q
     EFC36169.1 651 DACVKFIEEAIDSQ----GTILVHCKAGVSRSASMV-IAYVMKKFKL-SLDEATQMVKEKRSQ 707
                    45667777777777....**************8865.6677777776.334555555555554 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.059   1.3e+02       5      15 ..      78      88 ..      77      90 .. 0.87
   2 ?    3.1   0.1     0.054   1.2e+02       4      15 ..     111     122 ..     109     124 .. 0.85
   3 ?    1.1   0.2      0.23   5.2e+02       5      16 ..     134     145 ..     131     146 .. 0.89
   4 ?    3.1   0.7     0.054   1.2e+02       3      15 ..     165     177 ..     164     178 .. 0.88
   5 ?    3.3   0.3     0.048   1.1e+02       3      14 ..     302     313 ..     300     317 .. 0.86
   6 !    6.3   0.3     0.005        11       2      16 ..     326     340 ..     325     341 .. 0.89
   7 ?   -2.9   2.4       4.6     1e+04       2      15 ..     352     365 ..     351     366 .. 0.91
   8 !    7.1   0.0    0.0028       6.3       3      17 ..     471     485 ..     469     485 .. 0.89
   9 !    7.2   0.2    0.0027       6.1       5      16 ..     496     507 ..     493     511 .. 0.89
  10 !   10.3   3.0   0.00027       0.6       2      16 ..     518     532 ..     517     532 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.059
       LRR_6  5 LteLdLsgNdI 15
                +++L+LsgN++
  EFC36169.1 78 VEHLELSGNQL 88
                589******98 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.054
       LRR_6   4 hLteLdLsgNdI 15 
                 +Lt LdLs N I
  EFC36169.1 111 SLTFLDLSNNMI 122
                 89*******966 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.23
       LRR_6   5 LteLdLsgNdIg 16 
                 L+ L+L  N I+
  EFC36169.1 134 LKILNLENNLIT 145
                 99*******998 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.054
       LRR_6   3 thLteLdLsgNdI 15 
                 ++L++L++s N I
  EFC36169.1 165 NCLESLNISKNLI 177
                 68*********88 PP

  == domain 5  score: 3.3 bits;  conditional E-value: 0.048
       LRR_6   3 thLteLdLsgNd 14 
                 +++++LdLs N+
  EFC36169.1 302 PNIQHLDLSKNK 313
                 6899*******7 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.005
       LRR_6   2 nthLteLdLsgNdIg 16 
                 ++++t+L+Ls ++++
  EFC36169.1 326 SPSITSLNLSNCQLD 340
                 5799********985 PP

  == domain 7  score: -2.9 bits;  conditional E-value: 4.6
       LRR_6   2 nthLteLdLsgNdI 15 
                 n+++++L L  N+I
  EFC36169.1 352 NNSIRKLILHNNNI 365
                 899*********99 PP

  == domain 8  score: 7.1 bits;  conditional E-value: 0.0028
       LRR_6   3 thLteLdLsgNdIgD 17 
                 ++++ LdLs N+IgD
  EFC36169.1 471 PNIEFLDLSENEIGD 485
                 68899*********9 PP

  == domain 9  score: 7.2 bits;  conditional E-value: 0.0027
       LRR_6   5 LteLdLsgNdIg 16 
                 L++ dLs+N+I+
  EFC36169.1 496 LKSIDLSFNNIS 507
                 9**********8 PP

  == domain 10  score: 10.3 bits;  conditional E-value: 0.00027
       LRR_6   2 nthLteLdLsgNdIg 16 
                  t+Lt+LdLs+N+++
  EFC36169.1 518 LTKLTSLDLSHNNLT 532
                 689**********97 PP

>> Init_tRNA_PT  Rit1 DUSP-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       2.1   4.6e+03      16      43 ..     142     166 ..     136     192 .. 0.63
   2 !   14.9   0.2   1.1e-05     0.024      15      77 ..     644     700 ..     631     709 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.1
  Init_tRNA_PT  16 nLrtalpkivdfvrkrlsedkkkkilva 43 
                   nL t l+++v+ ++++ se k   +l +
    EFC36169.1 142 NLITSLENLVKELNENKSEMK---LLNC 166
                   555556666666655544433...3333 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 1.1e-05
  Init_tRNA_PT  15 knLrtalpkivdfvrkrlsedkkkkilvacetGkdlsvgvaLailcklfddaklseeqsesni 77 
                   ++L  +++ +v+f+++ + ++   +ilv+c+ G + s+++++a ++k f   kls  ++++++
    EFC36169.1 644 EDLLPHIDACVKFIEEAIDSQG--TILVHCKAGVSRSASMVIAYVMKKF---KLS-LDEATQM 700
                   67888999*********98877..9************************...442.3333333 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.048   1.1e+02       3      17 ..      79      93 ..      77     101 .. 0.79
   2 ?    6.5   0.4     0.007        16       1      20 [.     111     130 ..     111     131 .. 0.90
   3 ?    4.5   0.8     0.032        72       2      16 ..     134     148 ..     133     151 .. 0.86
   4 ?    3.1   0.1     0.097   2.2e+02       2      16 ..     167     181 ..     166     187 .. 0.84
   5 ?    0.7   0.0      0.57   1.3e+03       4      20 ..     194     210 ..     191     212 .. 0.83
   6 ?    2.9   0.2      0.11   2.5e+02       1      11 [.     303     313 ..     303     325 .. 0.87
   7 ?   -0.6   8.7       1.5   3.5e+03       2      19 ..     329     354 ..     328     394 .. 0.83
   8 ?   -1.9   0.1       4.3   9.7e+03       2      16 ..     448     462 ..     447     465 .. 0.78
   9 ?    3.5   0.2      0.07   1.6e+02       1      19 [.     472     490 ..     472     492 .. 0.87
  10 ?    3.7   0.0     0.061   1.4e+02       2      14 ..     496     508 ..     495     514 .. 0.83
  11 ?    9.5   0.6   0.00075       1.7       1      18 [.     520     537 ..     520     551 .. 0.84
  12 ?    1.0   0.0      0.47     1e+03       2      12 ..     591     601 ..     591     620 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.048
       LRR_1  3 rhLdLsnnpllglpp 17
                +hL Ls+n+l+ ++ 
  EFC36169.1 79 EHLELSGNQLEYFIV 93
                8********965554 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.007
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+ LdLsnn + ++p++++
  EFC36169.1 111 SLTFLDLSNNMIKNFPIECL 130
                 6999********99999998 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.032
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L+ L+L+nn +++l+
  EFC36169.1 134 LKILNLENNLITSLE 148
                 99*******997765 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.097
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L++L++s n + ++p
  EFC36169.1 167 LESLNISKNLIQHFP 181
                 9********986665 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.57
       LRR_1   4 hLdLsnnpllglppnsf 20 
                 ++dL+ npl +l++n +
  EFC36169.1 194 SIDLGENPLQSLSINML 210
                 689******99988876 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnp 11 
                 n +hLdLs n 
  EFC36169.1 303 NIQHLDLSKNK 313
                 789*****997 PP

  == domain 7  score: -0.6 bits;  conditional E-value: 1.5
       LRR_1   2 LrhLdLsnnpl........lglppns 19 
                  ++L+Lsn++l         ++++ns
  EFC36169.1 329 ITSLNLSNCQLdesvsrifKSILNNS 354
                 579*******9555555554455555 PP

  == domain 8  score: -1.9 bits;  conditional E-value: 4.3
       LRR_1   2 LrhLdLsnnpllglp 16 
                  r+L Ls+ +l+++p
  EFC36169.1 448 IRSLTLSGLFLSSIP 462
                 689999999997665 PP

  == domain 9  score: 3.5 bits;  conditional E-value: 0.07
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 n + LdLs n ++++++n 
  EFC36169.1 472 NIEFLDLSENEIGDFSSNL 490
                 7899********9999985 PP

  == domain 10  score: 3.7 bits;  conditional E-value: 0.061
       LRR_1   2 LrhLdLsnnpllg 14 
                 L+++dLs n+++ 
  EFC36169.1 496 LKSIDLSFNNIST 508
                 9********9854 PP

  == domain 11  score: 9.5 bits;  conditional E-value: 0.00075
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++LdLs+n+l+ +p++
  EFC36169.1 520 KLTSLDLSHNNLTEFPID 537
                 79**********777654 PP

  == domain 12  score: 1.0 bits;  conditional E-value: 0.47
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L+L++n  
  EFC36169.1 591 LERLYLGGNGS 601
                 89******975 PP

>> PTPlike_phytase  Inositol hexakisphosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   6.3e-05      0.14     117     154 ..     649     687 ..     629     689 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.3e-05
                      HHHHHHHHHHTS.-TT-EEEEE-SSSSHHHHHHHHHHHH CS
  PTPlike_phytase 117 dfdalvsilkea.pektalvfnCqmGrgRTTtamviatL 154
                       +da v++++ea  ++  ++++C++G+ R+  +++++ +
       EFC36169.1 649 HIDACVKFIEEAiDSQGTILVHCKAGVSRSASMVIAYVM 687
                      59**********999**************9877666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (730 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       827  (0.0461264); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.77u 0.35s 00:00:01.12 Elapsed: 00:00:00.54
# Mc/sec: 4092.84
//
Query:       EFC36170.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.9e-06   26.4   2.7       0.11   12.6   0.0    3.3  3  Erf4       Golgin subfamily A member 7/ERF4 family
  ------ inclusion threshold ------
       0.11   12.8   9.1        2.6    8.5   2.0    2.6  2  ASFV_L11L  African swine fever virus (ASFV) L11L protein


Domain annotation for each model (and alignments):
>> Erf4  Golgin subfamily A member 7/ERF4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.44   3.9e+03      15      31 ..      58      74 ..      46      78 .. 0.78
   2 !   12.6   0.0   1.2e-05      0.11      54     105 ..      92     144 ..      82     151 .. 0.83
   3 !   11.1   0.6   3.6e-05      0.32      14     108 ..     191     307 ..     185     315 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.44
        Erf4 15 pqFstllppeLsgyise 31
                 qF+t+  p L++++++
  EFC36170.1 58 QQFETETLPLLDNLLNR 74
                48999999999999876 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 1.2e-05
        Erf4  54 vrnildnvlglltlylwslvlkthykkklkk.lekyieelNeelfkerglkii 105
                   +++ ++l  + + ++ l+++++ ++klkk +e++ie+ Ne +fk++gl ++
  EFC36170.1  92 LFSLIGSALPTFIGCIFMLFFNYERNRKLKKnMENIIEQENELNFKPKGLLLV 144
                 5567788888999999******99999998779****************7443 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 3.6e-05
        Erf4  14 apqFstllppeLsgy..iseeefeeiinkiNeilaeafspysvrnildnvlglltly................lwslvlk....thykkklkk.....l 85 
                 +  F ++lp+ +s++  +s+ ++ e+i+++N+i+ ++ ++ + r i++ +   l +                 +++l++k    +++k    +     +
  EFC36170.1 191 TRLFNQELPQCISERfgLSQIDWGETIEEMNRIYLSEIEM-EERLIIKPLYCYLFACsflfnipilvtfpipiIYYLIVKylkiNKFK----QsnqvlM 284
                 5569999**999999999***************9999887.66666655444443334556777777777776555555544443333....2444568 PP

        Erf4  86 ekyieelNeelfkerglkiispr 108
                 e +i+e Ne++f ++gl +   +
  EFC36170.1 285 ESFISERNEKVFVPKGLYLNLIQ 307
                 99************998444333 PP

>> ASFV_L11L  African swine fever virus (ASFV) L11L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.8   0.00039       3.5      16      64 ..      82     132 ..      67     137 .. 0.83
   2 ?    8.5   2.0   0.00029       2.6       4      28 ..     253     277 ..     250     288 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00039
   ASFV_L11L  16 iflysyfkiklhklitial..flgclffilrdfcfppmlwtilqnitltln 64 
                  +++s +   l  li  al  f+gc+f+++ ++     l + ++ni    n
  EFC36170.1  82 FYMFSMLAASLFSLIGSALptFIGCIFMLFFNYERNRKLKKNMENIIEQEN 132
                 678999999******999877********9999999999999988876655 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00029
   ASFV_L11L   4 pllvmapiplvliflysyfkiklhk 28 
                 p+lv  pip++  ++  y+ki   k
  EFC36170.1 253 PILVTFPIPIIYYLIVKYLKINKFK 277
                 9********************8776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 1979.25
//
Query:       EFC36171.1  [L=970]
Description: leucine rich repeat protein with F-box domain [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-12   47.4  53.3     0.0012   19.2   7.0   10.0  8  LRR_4     Leucine Rich repeats (2 copies)
      6e-06   25.9   7.3    0.00013   21.6   5.1    8.8 10  LRR_8     Leucine rich repeat
    0.00055   19.8  40.3       0.86    9.8   0.1   10.7 12  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
        3.3    8.6  40.5         13    6.8   1.8   10.8  9  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.8   0.1    0.0091        41       3      17 ..     278     292 ..     278     298 .. 0.81
   2 ?    4.3   0.4     0.013        57       3      33 ..     427     461 ..     425     471 .. 0.75
   3 !   19.2   7.0   2.6e-07    0.0012       2      38 ..     495     533 ..     494     546 .. 0.91
   4 !    5.8   5.6    0.0044        20       8      38 ..     597     631 ..     590     643 .. 0.83
   5 ?    4.3   0.5     0.013        59       3      24 ..     669     691 ..     667     738 .. 0.84
   6 !   16.8   0.2   1.5e-06    0.0067       1      37 [.     754     795 ..     754     804 .. 0.82
   7 !   12.3   0.1   3.8e-05      0.17      15      39 ..     825     850 ..     810     863 .. 0.84
   8 ?    4.2   0.6     0.014        64      16      41 ..     908     933 ..     906     946 .. 0.65

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0091
                 --EEE--SS---E-S CS
       LRR_4   3 LevLdLsnNqltdip 17 
                 Le+L+Ls++ +t  +
  EFC36171.1 278 LETLNLSHCLITNQS 292
                 899999999999644 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.013
                 --EEE--SS---E-S-..HH...H.-TT--EEE-.-S CS
       LRR_4   3 LevLdLsnNqltdipl..le...k.lpnLkeLdLsgN 33 
                 L++L+ sn  + +i    ++   + +pnL+ L+  g+
  EFC36171.1 427 LKSLNMSN--IHEITHdsFKlipQlFPNLTALSFEGC 461
                 999****9..888877654466788*****9997665 PP

  == domain 3  score: 19.2 bits;  conditional E-value: 2.6e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 nL++L+L  ++++d +   l++l nL++L+Ls+N ++t+
  EFC36171.1 495 NLKKLNLKKTKISDAGVrnLQSLINLEYLNLSENKQLTN 533
                 9*************99977779************88875 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0044
                 --SS---E-S-.....HHH-TT--EEE-.-S----- CS
       LRR_4   8 LsnNqltdipl.....leklpnLkeLdLsgNnlitd 38 
                  sn+++ ++++     ++ + nL +L+Ls++ l++d
  EFC36171.1 597 ASNTNIHSLQNnvknsFA-FNNLSVLNLSHCKLLDD 631
                 688889998888766677.************66655 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.013
                 --EEE--SS.---E-S-HHH-TT CS
       LRR_4   3 LevLdLsnN.qltdiplleklpn 24 
                 L++L+++n+ ++td+ +   lp+
  EFC36171.1 669 LKILHINNCvHITDLTFEHILPS 691
                 999*****999**9988332554 PP

  == domain 6  score: 16.8 bits;  conditional E-value: 1.5e-06
                 SS--EEE--SS---E-S-HH.....H.-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdiplle.....k.lpnLkeLdLsgNnlit 37 
                 +nL++LdLs ++l+ i+  +     + ++nL+ +d s++ +i+
  EFC36171.1 754 KNLKILDLS-CNLKGIDDENiseaiSaMTNLEWIDFSHCDRIS 795
                 79*******.58******555578855**********997774 PP

  == domain 7  score: 12.3 bits;  conditional E-value: 3.8e-05
                 E-S-HHH-TT--EEE-.-.S-----G CS
       LRR_4  15 diplleklpnLkeLdLsg.Nnlitdl 39 
                 +ipll+++++L++L+Lsg N l++++
  EFC36171.1 825 SIPLLRSCKSLEVLYLSGiNILPQQF 850
                 7999**************66444555 PP

  == domain 8  score: 4.2 bits;  conditional E-value: 0.014
                 -S-HHH-TT--EEE-.-S-----GGG CS
       LRR_4  16 iplleklpnLkeLdLsgNnlitdlde 41 
                 +++l +l+nL +L Ls    ++dl  
  EFC36171.1 908 LGFLVSLDNLVTLRLSTHEELEDLGA 933
                 56666777777777766655555544 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   1.6     0.058   2.6e+02      26      61 .]     253     288 ..     250     290 .. 0.55
   2 ?   -1.4   0.1      0.46     2e+03       8      46 ..     430     444 ..     417     456 .. 0.60
   3 !   21.6   5.1   2.9e-08   0.00013       1      54 [.     494     545 ..     494     553 .. 0.92
   4 ?    3.6   4.3     0.012        54      18      61 .]     583     628 ..     580     628 .. 0.83
   5 ?    1.3   1.7     0.064   2.9e+02       2      35 ..     617     652 ..     616     678 .. 0.68
   6 ?   -1.8   0.0      0.59   2.6e+03      47      57 ..     719     729 ..     716     737 .. 0.68
   7 !   13.5   0.0     1e-05     0.045      18      59 ..     746     791 ..     745     794 .. 0.79
   8 ?    0.9   0.1     0.089     4e+02      46      58 ..     830     842 ..     793     846 .. 0.61
   9 ?    2.4   0.1      0.03   1.3e+02      22      52 ..     830     857 ..     808     860 .. 0.72
  10 ?    0.4   2.6      0.13   5.7e+02      19      54 ..     909     943 ..     891     944 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.058
                 T--EEE--SS---GGGGGGGTT--S..-.EEE--SS-- CS
       LRR_8  26 nLkvLdLsnNllttlspgafsgLps..LrsLdLsgNrL 61 
                 +L  L+Ls N   +++ ++++ L+   L+ L+Ls++ +
  EFC36171.1 253 GLSNLNLSLN--GRVHDDWMMLLREipLETLNLSHCLI 288
                 4555666666..44555555555543356666666654 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.46
                 -TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGT CS
       LRR_8   8 LsnNrltslddeaFkglsnLkvLdLsnNllttlspgafs 46 
                 L+ ++++++  ++F                         
  EFC36171.1 430 LNMSNIHEITHDSF------------------------K 444
                 22233444444444........................3 PP

  == domain 3  score: 21.6 bits;  conditional E-value: 2.9e-08
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsL 54 
                 +nL++L+L ++++++ +    ++l nL++L+Ls+N  + l ++++  L+ L++L
  EFC36171.1 494 RNLKKLNLKKTKISDAGVRNLQSLINLEYLNLSEN--KQLTNHCLKFLKDLKFL 545
                 79*********************************..78888899999999888 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.012
                 TTSSTT-TT--EEE--SS---GGGGGG..GTT--S-.EEE--SS-- CS
       LRR_8  18 deaFkglsnLkvLdLsnNllttlspga..fsgLpsLrsLdLsgNrL 61 
                 +e F ++++L++ + sn ++++l +++     +++L  L+Ls+++L
  EFC36171.1 583 PEHFANFPKLNYWNASNTNIHSLQNNVknSFAFNNLSVLNLSHCKL 628
                 7899******************987642245567*********997 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.064
                 T-SEEE-TTS--SEE-..TTSSTT-TT--EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltsld..deaFkglsnLkvLdLsnN 35 
                 nL++L+Ls+ +l + +  +++F++l+ L + ++s+ 
  EFC36171.1 617 NLSVLNLSHCKLLDDNsmKKFFESLNCLCEVNISST 652
                 677788888775444322455666777777777766 PP

  == domain 6  score: -1.8 bits;  conditional E-value: 0.59
                 T--S-.EEE-- CS
       LRR_8  47 gLpsLrsLdLs 57 
                 +Lp++++L+L+
  EFC36171.1 719 DLPKVEKLYLT 729
                 56666666665 PP

  == domain 7  score: 13.5 bits;  conditional E-value: 1e-05
                 TTSSTT.-TT--EEE--SS---GGGG....GGGTT--S-.EEE--SS CS
       LRR_8  18 deaFkg.lsnLkvLdLsnNllttlsp....gafsgLpsLrsLdLsgN 59 
                 +eaF + ++nLk+LdLs+N l+ ++     +a+s +++L+++d s++
  EFC36171.1 746 KEAFANiCKNLKILDLSCN-LKGIDDenisEAISAMTNLEWIDFSHC 791
                 5899999************.555554122268999999999999997 PP

  == domain 8  score: 0.9 bits;  conditional E-value: 0.089
                 TT--S-.EEE--S CS
       LRR_8  46 sgLpsLrsLdLsg 58 
                 ++++sL+ L+Lsg
  EFC36171.1 830 RSCKSLEVLYLSG 842
                 4444555555554 PP

  == domain 9  score: 2.4 bits;  conditional E-value: 0.03
                 TT-TT--EEE--SS---GGGGGGGTT--S-. CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLr 52 
                 +++++L+vL+Ls   ++ l p+ f+ L+ L+
  EFC36171.1 830 RSCKSLEVLYLSG--INIL-PQQFAKLATLE 857
                 6788999999987..5666.77777777776 PP

  == domain 10  score: 0.4 bits;  conditional E-value: 0.13
                 TSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EE CS
       LRR_8  19 eaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsL 54 
                 ++  +l nL +L Ls   +l+ l  ga+ +L++L +L
  EFC36171.1 909 GFLVSLDNLVTLRLSTHeELEDL--GALYDLHNLVYL 943
                 56678999999999865599999..699999999998 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.5      0.56   2.5e+03       5      17 ..     254     267 ..     252     268 .. 0.77
   2 !    8.6   0.0   0.00048       2.2       5      19 ..     278     292 ..     276     295 .. 0.89
   3 ?    0.9   0.3      0.14   6.4e+02       2      11 ..     424     433 ..     423     434 .. 0.88
   4 ?   -1.7   0.0      0.98   4.4e+03       4      23 ..     452     472 ..     451     473 .. 0.75
   5 !    9.8   0.1   0.00019      0.86       3      22 ..     494     513 ..     494     514 .. 0.90
   6 ?    3.8   0.5     0.017        76       4      16 ..     519     532 ..     516     533 .. 0.84
   7 !    8.2   0.2   0.00063       2.8       4      23 ..     617     637 ..     616     638 .. 0.89
   8 ?    2.7   0.7     0.037   1.7e+02       2      17 ..     666     682 ..     665     683 .. 0.91
   9 !    6.3   0.2    0.0026        12       2      13 ..     753     764 ..     753     771 .. 0.84
  10 ?   -1.2   0.0      0.67     3e+03       4      18 ..     782     797 ..     780     803 .. 0.74
  11 ?    0.0   0.0      0.27   1.2e+03       3      15 ..     808     821 ..     808     825 .. 0.84
  12 ?   -3.1   0.0       2.7   1.2e+04       2      12 ..     832     842 ..     831     842 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.56
       LRR_6   5 LteLdLsgNd.IgD 17 
                 L  L+Ls N+ + D
  EFC36171.1 254 LSNLNLSLNGrVHD 267
                 5679*****86666 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00048
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 L++L+Ls++ I+++ 
  EFC36171.1 278 LETLNLSHCLITNQS 292
                 99**********975 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.14
       LRR_6   2 nthLteLdLs 11 
                 +++L++L++s
  EFC36171.1 424 SRTLKSLNMS 433
                 68******98 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.98
       LRR_6   4 hLteLdLsgNd.IgDeGaeaL 23 
                 +Lt+L+  g+  ++++ +e +
  EFC36171.1 452 NLTALSFEGCSnFTNKCLEHI 472
                 899**9999987777655555 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.00019
       LRR_6   3 thLteLdLsgNdIgDeGaea 22 
                 ++L++L+L+  +I+D+G+  
  EFC36171.1 494 RNLKKLNLKKTKISDAGVRN 513
                 58***************975 PP

  == domain 6  score: 3.8 bits;  conditional E-value: 0.017
       LRR_6   4 hLteLdLsgNd.Ig 16 
                 +L++L+Ls N+ ++
  EFC36171.1 519 NLEYLNLSENKqLT 532
                 8*********9776 PP

  == domain 7  score: 8.2 bits;  conditional E-value: 0.00063
       LRR_6   4 hLteLdLsgNd.IgDeGaeaL 23 
                 +L  L+Ls+++ ++D  ++++
  EFC36171.1 617 NLSVLNLSHCKlLDDNSMKKF 637
                 7899***********999987 PP

  == domain 8  score: 2.7 bits;  conditional E-value: 0.037
       LRR_6   2 nthLteLdLsgNd.IgD 17 
                 +++L+ L+++ +  I+D
  EFC36171.1 666 KSTLKILHINNCVhITD 682
                 69**********99998 PP

  == domain 9  score: 6.3 bits;  conditional E-value: 0.0026
       LRR_6   2 nthLteLdLsgN 13 
                 + +L+ LdLs+N
  EFC36171.1 753 CKNLKILDLSCN 764
                 679********* PP

  == domain 10  score: -1.2 bits;  conditional E-value: 0.67
       LRR_6   4 hLteLdLsgNd.IgDe 18 
                 +L+  d s++d I+ +
  EFC36171.1 782 NLEWIDFSHCDrISSK 797
                 666679*****99876 PP

  == domain 11  score: 0.0 bits;  conditional E-value: 0.27
       LRR_6   3 thLteLdLsgNd.I 15 
                 +hLt+  +s+++ +
  EFC36171.1 808 RHLTHFAISYCKkV 821
                 6**********855 PP

  == domain 12  score: -3.1 bits;  conditional E-value: 2.7
       LRR_6   2 nthLteLdLsg 12 
                 + +L+ L Lsg
  EFC36171.1 832 CKSLEVLYLSG 842
                 889****9996 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0     0.011        50       2      13 ..     278     289 ..     277     304 .. 0.86
   2 ?    1.7   0.8      0.14   6.4e+02       1      21 [.     452     470 ..     426     473 .. 0.69
   3 ?    0.9   0.1      0.26   1.1e+03       1      23 []     495     517 ..     495     517 .. 0.79
   4 ?    6.8   1.8    0.0029        13       1      23 []     519     539 ..     519     539 .. 0.95
   5 ?    5.4   1.1    0.0084        38       1      18 [.     617     632 ..     617     655 .. 0.77
   6 ?    2.3   0.1     0.086   3.9e+02       2      18 ..     669     683 ..     668     692 .. 0.70
   7 ?    3.0   0.3     0.053   2.4e+02       1      11 [.     755     765 ..     755     775 .. 0.81
   8 ?    2.5   0.1     0.074   3.3e+02       1      17 [.     782     796 ..     782     810 .. 0.69
   9 ?   -0.7   0.0      0.85   3.8e+03       1       9 [.     834     842 ..     834     853 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.011
       LRR_1   2 LrhLdLsnnpll 13 
                 L++L+Ls++ ++
  EFC36171.1 278 LETLNLSHCLIT 289
                 9********874 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.14
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL+ L  +++++  +++ +++
  EFC36171.1 452 NLTALSFEGCSN--FTNKCLE 470
                 677777777774..5666665 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.26
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL++L+L    +++ + + +q+L
  EFC36171.1 495 NLKKLNLKKTKISDAGVRNLQSL 517
                 8******8888877777777765 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0029
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL++L+Ls n   +l++ ++++L
  EFC36171.1 519 NLEYLNLSENK--QLTNHCLKFL 539
                 8**********..*******987 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.0084
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 nL +L+Ls++ l  l +n
  EFC36171.1 617 NLSVLNLSHCKL--LDDN 632
                 899********9..3333 PP

  == domain 6  score: 2.3 bits;  conditional E-value: 0.086
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L+ L+++n+    +++ 
  EFC36171.1 669 LKILHINNCVH--ITDL 683
                 9********83..3333 PP

  == domain 7  score: 3.0 bits;  conditional E-value: 0.053
       LRR_1   1 nLrhLdLsnnp 11 
                 nL+ LdLs n 
  EFC36171.1 755 NLKILDLSCNL 765
                 8******8885 PP

  == domain 8  score: 2.5 bits;  conditional E-value: 0.074
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL+ +d s++    +++
  EFC36171.1 782 NLEWIDFSHCDR--ISS 796
                 8*********96..333 PP

  == domain 9  score: -0.7 bits;  conditional E-value: 0.85
       LRR_1   1 nLrhLdLsn 9  
                 +L++L+Ls+
  EFC36171.1 834 SLEVLYLSG 842
                 69*****87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (970 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1138  (0.0634726); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.73u 0.28s 00:00:01.01 Elapsed: 00:00:00.45
# Mc/sec: 6510.14
//
Query:       EFC36172.1  [L=567]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (567 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       823  (0.0459033); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 3357.81
//
Query:       EFC36173.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-24   85.3   0.1    3.8e-24   84.6   0.1    1.4  1  tRNA_bind      Putative tRNA binding domain
  ------ inclusion threshold ------
      0.098   11.3   0.3       0.12   11.0   0.3    1.0  1  Peptidase_S46  Peptidase S46
       0.12   12.7   5.5        7.3    6.9   5.5    2.5  1  RNA_pol_Rpb4   RNA polymerase Rpb4


Domain annotation for each model (and alignments):
>> tRNA_bind  Putative tRNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.6   0.1   6.4e-28   3.8e-24       1      95 [.      73     168 ..      73     169 .. 0.98

  Alignments for each domain:
  == domain 1  score: 84.6 bits;  conditional E-value: 6.4e-28
                 EEEEEEEEEEEETTSSTEEEEEEEESSSSEEEEEESCTTTSTHHHHTTEEEEEETTSESEEETTEEESSEE-EEEC.CESSCEEEEEESST--TTC CS
   tRNA_bind   1 lrvGkvleaeehpnadkLlvlkvdvGeeeprqivsgaknvyepeelvakkvvvvanlkpkklrGveSeGMilsaee.ldekevgilelpadveaGe 95 
                 l+v++v ++e+hp+++kL+++++++G+ e +  v+g++++y++ el+++k++ ++nlkpkkl Gv Se+Mil+    +de++v+il++  ++++G+
  EFC36173.1  73 LVVAQVESIEKHPESEKLYKITLNIGGDEKKGLVAGLRKFYTETELLNRKLISIVNLKPKKLAGVLSEAMILAGTAvGDENNVKILDPSPNAQVGD 168
                 79**************************************************************************99***************997 PP

>> Peptidase_S46  Peptidase S46
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.3     2e-05      0.12     386     487 ..      23     125 ..      10     158 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 2e-05
                    HHHHHHHHHHHHH....HH-HHHHHHHHHHHHHHCHHHH.CS--HHHHHHHHHHHHHHHHHHS-GGG--S----SS......-S-SHHCCCCC-TT CS
  Peptidase_S46 386 larklvrlaeerekpdaereeeyqeralealekelerid.kdldaevdkavlaallkeyreklkaerlpavdkvlgkeskgdlealvdrlvakskl 480
                    la+kl++ +   + + +e++ + ++++ ++ ++  ++ + k++++   + +++a+++++ +++++e+l ++   +g ++k+ l a +++++++++l
     EFC36173.1  23 LANKLQNNQPITSSKSSEKKVQQKKEQKPKQQQPPKKAAaKPTHPFHQTFLVVAQVESIEKHPESEKLYKITLNIGGDEKKGLVAGLRKFYTETEL 118
                    556666655555556667777777777777777777777255555555667789****************************************** PP

                    SSCHHHH CS
  Peptidase_S46 481 adeakrk 487
                     +++ + 
     EFC36173.1 119 LNRKLIS 125
                    9987654 PP

>> RNA_pol_Rpb4  RNA polymerase Rpb4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   5.5    0.0012       7.3      30     120 ..      56     203 ..      20     206 .. 0.57

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0012
                   C.CHHSHCHTCHHCHHHHHHHHHHHCTHHTTSSHHH................HHHHHHHHTTSTSTHHHHHHHHHCSTSSHHHH..HHHSTTGTT.. CS
  RNA_pol_Rpb4  30 k.isekeevkgnlnkilkktleyltnkfsrlkneek................fnelvellksfeLtkaEklqlvnlkPesavel..ktlieelee.. 105
                   + ++   + ++  ++ +  ++  ++    ++ ++ek                ++ l+++  ++eL +  ++++vnlkP++++ +  +++i       
    EFC36173.1  56 PpKKAAAKPTHPFHQTFL-VVAQVES-IEKHPESEKlykitlniggdekkglVAGLRKFYTETELLNRKLISIVNLKPKKLAGVlsEAMI----Lag 146
                   121111111111111111.1222222.4444444447778888888888888999999999*****************876432111111....111 PP

                   ..........................................TSTSHHHHHHHHHHH CS
  RNA_pol_Rpb4 106 ..........................................rfedeqleeiLdelk 120
                                                             r++ +q e+i++elk
    EFC36173.1 147 tavgdennvkildpspnaqvgdrvvlstdvniiepyvqsiedRCSPNQWEKIVKELK 203
                   223444447777777777777777777777777777777777888888888887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1653  (0.092197); expected 358.6 (0.02)
Passed bias filter:                      793  (0.04423); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.34s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1364.17
//
Query:       EFC36174.1  [L=595]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-15   57.7   0.1    4.5e-15   55.6   0.1    2.2  1  U-box     U-box domain
    4.4e-09   36.8   0.2    0.00019   21.9   0.1    2.5  2  Ank_2     Ankyrin repeats (3 copies)
    5.1e-06   26.9   0.0      0.014   16.0   0.0    3.3  3  Ank_4     Ankyrin repeats (many copies)
    4.8e-05   23.6   1.5       0.99    9.8   0.1    4.4  4  Ank_5     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.067   13.0   0.0       0.53   10.2   0.0    2.3  2  zf-Nse    Zinc-finger of the MIZ type in Nse subunit
      0.087   13.4   1.3         44    5.1   0.1    4.1  4  Ank_3     Ankyrin repeat


Domain annotation for each model (and alignments):
>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.6   0.1   1.5e-18   4.5e-15       1      71 [.     154     229 ..     154     231 .. 0.96

  Alignments for each domain:
  == domain 1  score: 55.6 bits;  conditional E-value: 1.5e-18
                 SSGGGB-TTT-SB-SSEEEETTTEEEEHHHHHHHHTT......SSB-TTT-SB--GGGSEE-HHHHHHHHHHHHHC CS
       U-box   1 iPdefldpitlelmkdPvilpsgvvvdrstiekhlls.....rdktdPftrepltqdqlipnlelKekIdefleek 71 
                 iP  f++pit  +m  Pv    g+v++r++i+++ +      ++ tdP+t+++++ + l+ + elK++I+efl+++
  EFC36174.1 154 IPHNFICPITKLIMFSPVRNMYGKVYERESIDQWWKTlsskqQQLTDPLTNQVVSDKALVEDVELKNQIQEFLNQN 229
                 8*********************************99888888889*****************************98 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.1   6.5e-08   0.00019       9      79 ..     384     478 ..     377     482 .. 0.74
   2 !   12.2   0.0   7.2e-05      0.21      24      80 ..     496     557 ..     480     560 .. 0.71

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 6.5e-08
       Ank_2   9 nlelvklLl.egadpn..k.ngktaLhyAakngnleivklLle..h............ad.......ndgrtpLhyAarsghleivklLlekgadi 79 
                 n +++++L+  ga ++  + ++++a h A++ +++ei+k L+   +            ++       +  +++ ++A+++++++i+++ ++ +a++
  EFC36174.1 384 NVSILDWLVsIGASISstNqFKQNAFHMACMTDQVEIAKHLCHlnNlvmtnnassvniVEerlsdevKRKWNAFYLAIWHNSQKIIDWVVD-DAHL 478
                 4578999998777776642599********************543266555556644511444446666*******************995.4555 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 7.2e-05
       Ank_2  24 k..ngktaLhyAakngnleivklLleh..ad..ndgrtpLhyAarsghleivklLlekgadin 80 
                 +    ++aL +Aa + n+ +++ L+++  ++  ++ + p+++++  + l+ +k+ + ++++ n
  EFC36174.1 496 SiyHPMNALSLAAYKKNIPLMEVLIKKfsFEvpDEKYHPIYWSCIANDLNGFKWIC-NYIETN 557
                 14466899999999998888999999767446578889999999999999999998.446655 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   4.5e-06     0.014      11      52 ..     382     422 ..     376     424 .. 0.92
   2 ?    1.8   0.0      0.13     4e+02      33      52 ..     451     470 ..     438     473 .. 0.82
   3 ?    4.9   0.0     0.014        40       3      53 ..     502     549 ..     501     550 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 4.5e-06
       Ank_4  11 sgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilk 52 
                 + ++ ++++L++ ga+i  + n   ++a+h+A+++ +vei+k
  EFC36174.1 382 FPNVSILDWLVSIGASISST-NQFKQNAFHMACMTDQVEIAK 422
                 568999*****88******9.******************987 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.13
       Ank_4  33 rsGetalhiAakrgnveilk 52 
                 ++ ++a++ A+++++ +i+ 
  EFC36174.1 451 KRKWNAFYLAIWHNSQKIID 470
                 468**********9866665 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.014
       Ank_4   3 taLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilkl 53 
                  aL  aa++ +++l + L+ k   +   + +++   +++  +  ++++ +k+
  EFC36174.1 502 NALSLAAYKKNIPLMEVLIKKfSFE---V-PDEKYHPIYWSCIANDLNGFKW 549
                 678899*************763454...6.999*********9999999988 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.1   0.00033      0.99       2      38 ..     392     429 ..     391     438 .. 0.81
   2 ?    2.1   0.0     0.087   2.6e+02      13      36 ..     452     473 ..     441     487 .. 0.78
   3 ?    3.8   0.0     0.026        78      17      36 ..     501     520 ..     498     529 .. 0.91
   4 ?    3.3   0.0     0.035   1.1e+02      15      39 ..     530     553 ..     526     567 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00033
       Ank_5   2 lehgpadvnrldgggntpLhvAakygaadvvrlLl..ar 38 
                 ++ g a++  +++++++++h+A+     ++++ L+  ++
  EFC36174.1 392 VSIG-ASISSTNQFKQNAFHMACMTDQVEIAKHLChlNN 429
                 5566.788899***********************95444 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.087
       Ank_5  13 dgggntpLhvAakygaadvvrlLl 36 
                 +++  +++ +A++++++ ++ + +
  EFC36174.1 452 RKW--NAFYLAIWHNSQKIIDWVV 473
                 444..99*********99998887 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.026
       Ank_5  17 ntpLhvAakygaadvvrlLl 36 
                 +++L +Aa++ + +++++L+
  EFC36174.1 501 MNALSLAAYKKNIPLMEVLI 520
                 69*****************9 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.035
       Ank_5  15 ggntpLhvAakygaadvvrlLlarg 39 
                 ++++p+ +++ ++ ++ +++++ + 
  EFC36174.1 530 EKYHPIYWSCIANDLNGFKWIC-NY 553
                 679******************9.44 PP

>> zf-Nse  Zinc-finger of the MIZ type in Nse subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   0.00018      0.53      11      42 ..     157     187 ..     150     195 .. 0.84
   2 ?   -0.3   0.0      0.33     1e+03       7      20 ..     193     206 ..     190     209 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00018
                 XSB-TTTSSB-SSEEEESSS--EEEHHHHHHH CS
      zf-Nse  11 slkCPltlqpfeePvtskkCpHvFEreaIlel 42 
                 ++ CP+t+  +  Pv++     v+Ere+I + 
  EFC36174.1 157 NFICPITKLIMFSPVRNMY-GKVYERESIDQW 187
                 567*************987.569***999876 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.33
                 SSBXXSB-TTTSSB CS
      zf-Nse   7 eerislkCPltlqp 20 
                 +++++l++Plt q 
  EFC36174.1 193 SKQQQLTDPLTNQV 206
                 67889999999875 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       1.6   4.8e+03      14      29 ..     384     398 ..     381     399 .. 0.78
   2 ?    5.1   0.1     0.015        44       3      22 ..     406     425 ..     404     431 .. 0.87
   3 ?    3.7   0.0     0.042   1.3e+02       4      24 ..     502     522 ..     499     527 .. 0.87
   4 ?   -1.7   0.0       2.4   7.1e+03       3      23 ..     532     552 ..     530     558 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.6
       Ank_3  14 nleivkfLlenkgadv 29 
                 n++i+++L+   ga +
  EFC36174.1 384 NVSILDWLVS-IGASI 398
                 6789*****9.68876 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.015
       Ank_3   3 etpLhlAarsgnleivkfLl 22 
                 ++++h+A++ + +ei+k L+
  EFC36174.1 406 QNAFHMACMTDQVEIAKHLC 425
                 789***********999987 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.042
       Ank_3   4 tpLhlAarsgnleivkfLlen 24 
                 ++L lAa   n+++++ L+++
  EFC36174.1 502 NALSLAAYKKNIPLMEVLIKK 522
                 799****************95 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 2.4
       Ank_3   3 etpLhlAarsgnleivkfLle 23 
                 + p+++ + +++l+  k++++
  EFC36174.1 532 YHPIYWSCIANDLNGFKWICN 552
                 678999999999987888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (595 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       787  (0.0438954); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 3589.99
//
Query:       EFC36175.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-10   41.2   0.9    1.9e-10   41.2   0.9    2.3  2  Chibby         Chibby family
     0.0066   16.2  24.1       0.01   15.5  24.1    1.3  1  CAF-1_p150     Chromatin assembly factor 1 complex p150 subun
  ------ inclusion threshold ------
      0.028   14.4   0.0      0.035   14.1   0.0    1.3  1  FIST_C         FIST C domain
       0.24   11.9   4.7       0.84   10.1   4.8    1.7  2  GOLD_2         Golgi-dynamics membrane-trafficking
       0.64   10.3   5.4       0.88    9.8   5.4    1.3  1  RNA_pol_Rbc25  RNA polymerase III subunit Rpc25
       0.66    8.5   1.2       0.82    8.2   1.2    1.1  1  FPN1           Ferroportin1 (FPN1)
       0.69    9.6   6.5       0.79    9.4   6.5    1.2  1  Connexin       Connexin
        3.1    7.5   7.2        4.4    7.0   7.2    1.2  1  EIIBC-GUT_N    Sorbitol phosphotransferase enzyme II N-termin
          5    5.8   7.8        5.8    5.6   7.8    1.1  1  Presenilin     Presenilin
        5.8    6.4  10.5        7.2    6.1  10.5    1.2  1  Sec62          Translocation protein Sec62
        7.3    4.7   9.7        8.8    4.5   9.7    1.1  1  Atrophin-1     Atrophin-1 family
        8.7    6.5  11.4         13    5.9  11.4    1.2  1  YqfQ           YqfQ-like protein
        9.8    6.9  20.0    3.7e+02    1.8  20.0    2.3  1  YabA           Initiation control protein YabA


Domain annotation for each model (and alignments):
>> Chibby  Chibby family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.2   0.9   1.3e-13   1.9e-10      71     115 ..      64     111 ..      19     112 .. 0.82
   2 ?   -0.4   3.5       1.1   1.5e+03      63      84 ..     139     160 ..     119     165 .. 0.65

  Alignments for each domain:
  == domain 1  score: 41.2 bits;  conditional E-value: 1.3e-13
      Chibby  71 s...keslrlkkenkqLeeEnnllklklevLLDmLtettaelhlleke 115
                 +    + +++k+++++Le+En llklk e+LLD+L+ tt++++ +e+ 
  EFC36175.1  64 KldhTDLQNIKERMEELEDENRLLKLKNEILLDLLSSTTLDAKYMEQT 111
                 0344899*************************************9986 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.1
      Chibby  63 sggaggasskeslrlkkenkqL 84 
                  ++++++++ke++r++ +n+q+
  EFC36175.1 139 RKEKEKKEKKEKKRMQSTNEQV 160
                 3334444457777777777766 PP

>> CAF-1_p150  Chromatin assembly factor 1 complex p150 subunit, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5  24.1   7.4e-06      0.01      15      97 ..      76     170 ..      64     175 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 7.4e-06
  CAF-1_p150  15 klklekekerlrkkl...........klerekeekkrlkeekke.ekerakeearrkkeeekekkekerrekkekdekekaeklrlkeekrkekl 97 
                 ++++  +++rl k +            l+++  e+  lk ++   +    +ee++++k+e+ke+keke++ekkek   + ++ + +k +  k+++
  EFC36175.1  76 RMEELEDENRLLKLKneilldllsstTLDAKYMEQTLLKIKNEGfHSINNQEEEEKEKREKKERKEKEKKEKKEKKRMQSTNEQVVKRDVPKRQI 170
                 44433333343333334445555555788888888887776654145578999**************************9999999999777665 PP

>> FIST_C  FIST C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   2.5e-05     0.035      35      77 ..      38      80 ..       6     116 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.5e-05
      FIST_C 35 vrhllgvdpedgslaladdveeGqrlqlmlrdaealiedlerl 77
                   +++v+p++gsl   +++ +G+ ++l ++d ++++e++e+l
  EFC36175.1 38 GKMMIKVNPDTGSLEYMGEIGQGEYIKLDHTDLQNIKERMEEL 80
                457899********************************88887 PP

>> GOLD_2  Golgi-dynamics membrane-trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.6   2.3e+03      30      59 ..      56      85 ..      51      97 .. 0.78
   2 ?   10.1   4.8   0.00061      0.84      48     106 ..     116     174 ..      99     179 .. 0.62

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.6
      GOLD_2 30 diGfGvyfewteatskavsvkvsesddeed 59
                +iG G y +  +++ +++  +++e +de++
  EFC36175.1 56 EIGQGEYIKLDHTDLQNIKERMEELEDENR 85
                588888888888888888888888877765 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00061
      GOLD_2  48 svkvsesddeedeeeeeeeekveeedvekgsvkaakprldeivpvyrrdsheevyaGsh 106
                  ++  +s ++++eee+e+ ek e ++ ek ++k +k  ++   +v++rd  +  ++ sh
  EFC36175.1 116 KNEGFHSINNQEEEEKEKREKKERKEKEKKEKKEKKRMQSTNEQVVKRDVPKRQISSSH 174
                 44444455555555555555556666666665555555555667888998888777777 PP

>> RNA_pol_Rbc25  RNA polymerase III subunit Rpc25
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   5.4   0.00064      0.88      55     107 ..      99     151 ..      61     162 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00064
                    SSEEEEE-TTSEEEEEEEEEEE-------HHHHHCHHHCCTS-SS--SSTTS- CS
  RNA_pol_Rbc25  55 eeeelyldvgeeirfrveeeifvdvkpkspkeaeleeeeaseeeaeeeeeeke 107
                     +++l  +  e+  +++++e f+ ++ ++++e+e++e+++++e++++e++ek+
     EFC36175.1  99 SSTTLDAKYMEQTLLKIKNEGFHSINNQEEEEKEKREKKERKEKEKKEKKEKK 151
                    67788888899999********9998888887766544333333333332222 PP

>> FPN1  Ferroportin1 (FPN1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   1.2   0.00059      0.82     184     249 ..      97     162 ..      86     167 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00059
        FPN1 184 filvvnlvsvvveyillakvYrkvpalaekeekkeeeeeeakeeetkakeaksesslvkrvaeavk 249
                 ++++  l +  +e  ll   ++++ +++++ee+++e++e+++ +e ++ke+k++++++++ ++ vk
  EFC36175.1  97 LLSSTTLDAKYMEQTLLKIKNEGFHSINNQEEEEKEKREKKERKEKEKKEKKEKKRMQSTNEQVVK 162
                 5666666677788889999999999**999999999999888877777777777777776666665 PP

>> Connexin  Connexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.5   0.00057      0.79      97     142 ..     122     163 ..      65     179 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00057
    Connexin  97 kiakeekekekeeeekeeeekeeekkkkkekkkkkkkeeekekkke 142
                 +i+++e+e+++++e+ke++eke+    k++k+kk++++++++  k+
  EFC36175.1 122 SINNQEEEEKEKREKKERKEKEK----KEKKEKKRMQSTNEQVVKR 163
                 22222222221111111111111....1222222222222222222 PP

>> EIIBC-GUT_N  Sorbitol phosphotransferase enzyme II N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   7.2    0.0032       4.4     110     155 ..     115     160 ..      99     179 .. 0.60

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0032
  EIIBC-GUT_N 110 vkeeqieladeeeeeeeeeeeekeeaeekekkketkkkiteqeeke 155
                  +k+e  + ++++eeee+e++e+ke++e+++k+k++kk++++++e+ 
   EFC36175.1 115 IKNEGFHSINNQEEEEKEKREKKERKEKEKKEKKEKKRMQSTNEQV 160
                  5556666666666666666666666555555555555555444443 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   7.8    0.0042       5.8     215     279 ..      98     162 ..      71     179 .. 0.42

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0042
  Presenilin 215 iYsatvvvlaaeekkaevaeseeeeeaekkkeeasesskeeeseeesseksaqsseseeeseees 279
                 + s+t  + ++e++  + +++  ++ +++++ee+++++k+e++e+e++ek+++++ ++++++  +
  EFC36175.1  98 LSSTTLDAKYMEQTLLKIKNEGFHSINNQEEEEKEKREKKERKEKEKKEKKEKKRMQSTNEQVVK 162
                 44444444444444222222222222222222222222222222222222222222222222222 PP

>> Sec62  Translocation protein Sec62
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1  10.5    0.0052       7.2      48      91 ..     115     161 ..      66     174 .. 0.59

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0052
       Sec62  48 kksqlalrveklkekekkkkkee...kkkkkkkkkkvkleieeeqef 91 
                 +k++   ++++++e+ek+k++++   +k+kk+kk+k +++ ++eq++
  EFC36175.1 115 IKNEGFHSINNQEEEEKEKREKKerkEKEKKEKKEKKRMQSTNEQVV 161
                 33333333333322222222222223667777888888888888876 PP

>> Atrophin-1  Atrophin-1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   9.7    0.0064       8.8     571     625 ..      99     153 ..      90     176 .. 0.62

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0064
  Atrophin-1 571 asskl.akkreealekakreaeqkareekerekerekererererereaeraakas 625
                 +s+ l ak  e++l k+k e  ++  ++ e eke+ +++er+ e+e++ ++  k  
  EFC36175.1  99 SSTTLdAKYMEQTLLKIKNEGFHSINNQEEEEKEKREKKERK-EKEKKEKKEKKRM 153
                 555554777888999999998888776666666654444442.3333333333222 PP

>> YqfQ  YqfQ-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  11.4    0.0095        13     120     169 ..     126     175 ..     108     178 .. 0.60

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0095
        YqfQ 120 vevseteeseknkkkkpkakkkkkkkkkkdvkeeeiekeapkekkvqskG 169
                 +e  e e+ ek+++k+ + k+kk+kk+ + + e++++++ pk++  +s+G
  EFC36175.1 126 QEEEEKEKREKKERKEKEKKEKKEKKRMQSTNEQVVKRDVPKRQISSSHG 175
                 22223333344444444445556666777888999999999997544445 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8  20.0      0.27   3.7e+02      20      53 ..      66     130 ..      58     164 .. 0.72

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.27
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH...............................X CS
        YabA  20 lleeleelkeelaelleenaeLeleneklrerl...............................e 53 
                  +++l+++ke+++el +en+ L+l ne l ++l                               e
  EFC36175.1  66 DHTDLQNIKERMEELEDENRLLKLKNEILLDLLssttldakymeqtllkiknegfhsinnqeeeE 130
                 5789*****************************66666666666666666666666666544431 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3627  (0.202298); expected 358.6 (0.02)
Passed bias filter:                      977  (0.0544927); expected 358.6 (0.02)
Passed Vit filter:                       230  (0.0128284); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 1099.47
//
Query:       EFC36176.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.1e-10   39.1   0.7    2.8e-07   29.8   0.1    2.3  2  3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase fami
  ------ inclusion threshold ------
      0.013   15.6   2.2      0.023   14.8   2.2    1.3  1  NST1       Salt tolerance down-regulator


Domain annotation for each model (and alignments):
>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.1   0.00018       1.6       1      33 [.      14      49 ..      14     115 .. 0.76
   2 !   29.8   0.1   3.2e-11   2.8e-07     163     265 ..     117     211 ..     108     220 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00018
   3Beta_HSD  1 vvtGgaGFlGralvkeLvrlee...lkevrvlDlre 33
                ++tGg+G + ++l keL+  +e   + ++  lD++ 
  EFC36176.1 14 LITGGCGCIAQHLTKELLLNHEelnIDKIILLDVQR 49
                69*************998766533345566666543 PP

  == domain 2  score: 29.8 bits;  conditional E-value: 3.2e-11
   3Beta_HSD 163 rtlknggrlyTcaLR.pagiyGegdkllvpllkqlaklglalfkigdeevlsdrvYvgNvawahilAaralqdpkkkssvagqayfisddsPvesyddf 260
                 r++k+ ++l+   L   ++iyGegd+ +++l++   +++  l    d +++    Y+gN a+ahilA ++l+++   + v+g ++ + +++  + y++ 
  EFC36176.1 117 RPFKENQKLNSLVLTlCMTIYGEGDQNTLNLIQSN-RTN--L----DISAKGHSLYAGNAAHAHILAFKQLLNN--PNMVRGMTFSVHENNFGQLYFKA 206
                 5677777888777753799*********9988653.333..2....333444569******************9..89999*99999888777766666 PP

   3Beta_HSD 261 nltll 265
                 ++ ++
  EFC36176.1 207 LRGIM 211
                 66555 PP

>> NST1  Salt tolerance down-regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   2.2   2.6e-06     0.023      66     115 ..      56     106 ..      39     112 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.6e-06
        NST1  66 ittssarsvknnppsvssaalrsakkvskdrsiwntssqE.ereklkeFWl 115
                   ++++++++n+++  s++  +s+++++++++iw+  s E e+ek+k + +
  EFC36176.1  56 HVYNNSNTINNTTTIESNNDDNSNNNSNSNNNIWKYPSLEiEKEKIKFYQI 106
                 55677788888888888899999999********************97765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       930  (0.0518713); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1724.31
//
Query:       EFC36177.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0077   15.8   0.7      0.018   14.6   0.2    1.8  2  DUF1700   Protein of unknown function (DUF1700)


Domain annotation for each model (and alignments):
>> DUF1700  Protein of unknown function (DUF1700)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.2     1e-06     0.018       1      62 [.       1      67 [.       1      90 [. 0.72
   2 ?   -1.0   0.0      0.06   1.1e+03       3      15 ..     118     130 ..     116     132 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1e-06
     DUF1700  1 mnkkefLkeLesaLeklpeeekkdi..lsdYeehFesgkeeGk...sEeeivkeLgdPkeIakelta 62
                m  +e+L+ Le++L +++++e ++i  +++Y     s++ + k     + i+ +L++Pk  +k   +
  EFC36177.1  1 MIYQEYLNDLENNLTNMENNEEEEIpsMEEYFSQIPSNEIKFKkplKVKLIISDLNQPKLASKMAST 67
                5569********************9556666655555554444111346688999999887776554 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.06
     DUF1700   3 kkefLkeLesaLe 15 
                   e+L+eLe+ L+
  EFC36177.1 118 EIEYLNELENCLK 130
                 569******9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       791  (0.0441185); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 839.19
//
Query:       EFC36178.1  [L=1832]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      5e-16   58.5  20.6    7.3e-14   51.4  11.7    3.4  3  REJ          REJ domain
    1.2e-10   41.6 120.6    3.2e-05   24.2   8.8    9.8  8  EGF_2        EGF-like domain
     0.0023   17.6   8.3     0.0088   15.7   0.8    3.0  3  DUF3494      Protein of unknown function (DUF3494)
  ------ inclusion threshold ------
      0.036   14.2   0.4      0.036   14.2   0.4    7.7  8  Laminin_EGF  Laminin EGF domain


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.5      0.17   7.7e+02     164     201 ..     627     664 ..     593     678 .. 0.70
   2 !   11.3   0.0   2.4e-05      0.11      99     188 ..     840     953 ..     834     965 .. 0.76
   3 !   51.4  11.7   1.6e-17   7.3e-14      47     426 ..     989    1342 ..     952    1357 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.17
         REJ 164 fpaselvanltynftltvskrs.rksasteqtilvvdge 201
                 +++s++v+n+  n  +t + +s  +++ t+ t+ vv+++
  EFC36178.1 627 IDNSTVVSNT-TNWNVTSNSNStNTTSPTNTTVIVVNSN 664
                 5677777774.4444444444433366666666666665 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 2.4e-05
         REJ  99 gnltLdGseSyDpdeddhsqsqlsYeWlcrrsq......pmngrnndnpllnidpeals..........................gtllsssts..slt 163
                 + + +dGs Sy  d+++     l+Y+W++++ +      +       ++++ +  + ++                           t+++++++  sl+
  EFC36178.1 840 DAIPVDGSLSYSVDRKP-----LKYYWSVVNASsmtdvfA------VMTAQPNFMVSAElapgsykiklqvysvylnkfstpvysKTFTKATKPlpSLS 927
                 67889********9997.....99*****99994444442......333333333333355566678888999999999999999777777776669** PP

         REJ 164 fpaselvanl.tynftltvskrsrks 188
                 ++++e   +  ty+f lt++k+ ++s
  EFC36178.1 928 IFKDETIIERfTYQFPLTIRKSITTS 953
                 99999988888**********98644 PP

  == domain 3  score: 51.4 bits;  conditional E-value: 1.6e-17
         REJ   47 s.fLpygtyvflltvslsgepsleatdiikvrvepspLvavIkGGssrvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpl 142 
                     ++  ty f++++ +s++psl+ ++++ ++v    ++             +g+ tL   + +Dp+   +s     ++W+c + +        + l
  EFC36178.1  989 VkYFEESTYIFKVSAFYSSDPSLTVSTTVRLNVLTPNITLG-----VLQLEAKGDHTLLKVDYSDPETLINSDIVSVWTWSCIDHS-------SQKL 1073
                  33556689999999999999988888888888877777775.....45677778999999999999988888744457999*7777.......2222 PP

         REJ  143 lnidpealsgtllssstssltfpaselvanl.tynftltvskrsrksasteqtilvvdgepplvsiecisncngkvnpndrlvllas.clncakdlk 237 
                  l+  ++     + +s++ ++ ++++ +      ++++l+v k +  ++ t+ ti   +  pplv +  i+ ++  v   + l +++  ++++ + ++
  EFC36178.1 1074 LSFLQS-----VSESKSTIFNVTTQLFDVVPsSIHLRLKVEKFNG-KSLTKDTIINFNNIPPLVNVINIEPKSSVVVRGQLLTVQVLvSSSAISAIS 1164
                  222222.....22234445555555443333378888*******9.99****************************999999999887777766665 PP

         REJ  238 dvtfeWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltl.rvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaftv 333 
                  +  + W+l    +  ++ + ++++++ + + +++++i++++L +g++  ++l ++ + +g++ + +s+ f++   P  ++c v+P  g al t+f++
  EFC36178.1 1165 NS-VVWTL----DAIKVDKSQVSEQTLDDKRTSTVYIDTSNLVEGSEHFVSLfTYDASKGTS-SESSYGFQIAVSPKPCECAVLPPYGSALDTDFNF 1255
                  44.47*44....4444456666778888888889******************4444444444.6********************************* PP

         REJ  334 rCqgw.tDkd..qPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDn.kgarvsvsltitVkppavnnstieellenr 426 
                   C +  + ++    L Y +    +++sg    ly+  +    s++LP +++  ++k+t +++  D+  ga+++v + +++++p v++   e++ ++ 
  EFC36178.1 1256 ICYNCkS-EEnhIDLRYGF---IDDRSGLKVPLYNLGEV--YSSKLPAPFE--GSKLTCFFEMVDTtTGAFTTVYKDVKIEKPVVSEI--EQVQNFV 1342
                  **77753.432589*****...*************9999..9*********..9***999998886257888************9988..5555544 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   3.8      0.33   1.5e+03      14      32 .]       2      19 ..       1      19 [. 0.85
   2 ?    2.0   8.8     0.063   2.8e+02       5      27 ..     251     272 ..     247     276 .. 0.81
   3 !   24.2   8.8   7.1e-09   3.2e-05       5      32 .]     289     314 ..     285     314 .. 0.89
   4 !    7.8   9.3   0.00094       4.2       5      32 .]     327     353 ..     324     353 .. 0.86
   5 !   11.8   5.6   5.2e-05      0.23      11      32 .]     552     572 ..     549     572 .. 0.93
   6 !   18.5   7.9   4.4e-07     0.002       5      32 .]     585     611 ..     581     611 .. 0.91
   7 ?    4.0  17.3     0.015        68       1      32 []     665     710 ..     665     710 .. 0.57
   8 !    9.7   3.5   0.00024       1.1       7      32 .]    1393    1415 ..    1386    1415 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.33
       EGF_2 14 CvnqcGqCdCdsgyqGktC 32
                C + + +C C+ gy   +C
  EFC36178.1  2 CTENE-KCTCFVGYVNQYC 19
                87566.8*******99999 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.063
       EGF_2   5 deiCgghGtCvnqcGq.CdCdsgy 27 
                 ++ C g G Cv  +   C+C++gy
  EFC36178.1 251 SSVCAGIGNCV--GYDsCSCPNGY 272
                 688********..6545******8 PP

  == domain 3  score: 24.2 bits;  conditional E-value: 7.1e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghGtC    + C+Cdsg++G +C
  EFC36178.1 289 SSVCSGHGTCS--SNICSCDSGFSGSDC 314
                 689*******9..668************ PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.00094
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ +G C  ++  C C+ gy G +C
  EFC36178.1 327 NASCNSNGLCKYSN-TCICKIGYKGTYC 353
                 677*******9555.8************ PP

  == domain 5  score: 11.8 bits;  conditional E-value: 5.2e-05
       EGF_2  11 hGtCvnqcGqCdCdsgyqGktC 32 
                 +G+C+ ++  C C++gy+G +C
  EFC36178.1 552 RGSCIGPN-ICNCSNGYYGSQC 572
                 8****888.9************ PP

  == domain 6  score: 18.5 bits;  conditional E-value: 4.4e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+GtC +++ +C C++g++  tC
  EFC36178.1 585 SSVCSGNGTCYSFN-NCTCFTGFYDSTC 611
                 789********999.8**********99 PP

  == domain 7  score: 4.0 bits;  conditional E-value: 0.015
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdC.................dsgyqGktC 32 
                 C + +++C+ghG+C   + +C+C                 ++gy+G++C
  EFC36178.1 665 CTS-SLNCSGHGVCK--NSKCSCyststagywtgywcnqcKPGYYGDQC 710
                 766.478*******7..66777754444333333333333555555555 PP

  == domain 8  score: 9.7 bits;  conditional E-value: 0.00024
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                  iC+ +G+     G+C+C++gy G +C
  EFC36178.1 1393 ICQ-NGYDL--SGVCKCQDGYIGRNC 1415
                  676.46655..89************9 PP

>> DUF3494  Protein of unknown function (DUF3494)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.8     2e-06    0.0088     102     200 ..     121     210 ..     115     217 .. 0.79
   2 !    5.5   0.0    0.0026        12      62     178 ..     428     535 ..     387     555 .. 0.63
   3 ?   -2.6   0.6      0.76   3.4e+03      26      59 ..     601     635 ..     583     670 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2e-06
                 EEEEESS-EEE-SS-EEEE-TT-TT--EEEEESS-EEE-TT--EEEETT--GGGEEEEESS-EEE-TT-EEEEEEEESS-EEE-TT-EEEEEEEESSSE CS
     DUF3494 102 GvYkstsavtittgdltLDaqGdanavwiFqiagtLtvasgssvvLinGAqaknvfWqvggsatlgtgstfeGtilaqtsitlstgatvnGrllaqtga 200
                 G+Yk+t++ +  + ++++    +  +  iF i g+  v+++ +vv+++ A++ n +W v   a +   ++f+G+ +a+ sit+s++  ++G +++   +
  EFC36178.1 121 GTYKLTAGWKGPS-KVVI----STVDRVIFAIFGDNFVSENVEVVFTECASPYNLYWIVDKTAKIS--GNFKGNLIAR-SITASNA-VITGTIFSISTT 210
                 5666666666533.6666....445667999999999999*********************99996..57*****996.6777654.789998886654 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0026
                 .HHHHHHHHHHHHHHHHHSSS-TT-EEE--SB-TTEEEES.EEEEESS-EEE-SS-EEEE-TT-TT--EEEEESS-EEE-TT--EEEETT--GGGEEEE CS
     DUF3494  62 atltqAvadletAynalagrslpditelgagelggrtLap.GvYkstsavtittgdltLDaqGdanavwiFqiagtLtvasgssvvLinGAqaknvfWq 159
                 ++  +A++ ++tA + ++++s+  ++ + + ++ ++ +++ GvY +  +  i  +++++  +G      +F++ g L+ + + +v++i  A+++ vfW 
  EFC36178.1 428 KNDWEANQAVSTALSLVQKLSALPCNYTFGLNVPNLYINQgGVYCFPNGW-IGPSKVVI--NGP--ERVVFKT-GYLNYN-NFEVTMISNASPSSVFWI 519
                 44445556666666555555544433333356666655542688885533.33457888..444..3357775.678888.99***************7 PP

                 ESS-EEE-TT-EEEEEEEE CS
     DUF3494 160 vggsatlgtgstfeGtila 178
                  ++ +     ++f+Gt +a
  EFC36178.1 520 ATQFL---ISGDFKGTLMA 535
                 54433...34566666665 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.76
                 GGEES--B-S.TTBTTEES--.....EE-TT--HH CS
     DUF3494  26 taitGfadel.atgtestsglvltGkvyaadaaaa 59 
                 t +tGf d++ ++   +++++ +t  ++ ++ +++
  EFC36178.1 601 TCFTGFYDSTcSCKIGTDCTIRNTSYIDNSTVVSN 635
                 55666666553333334443332333333333322 PP

>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   3.0       3.8   1.7e+04      17      33 ..       5      21 ..       2      24 .. 0.82
   2 ?   -4.2   1.7         4   1.8e+04      18      31 ..     264     276 ..     243     282 .. 0.64
   3 ?   -6.3  15.5         4   1.8e+04       3      32 ..     281     315 ..     266     319 .. 0.80
   4 ?    6.0   5.4     0.003        14       3      33 ..     319     355 ..     317     358 .. 0.86
   5 ?    0.5   6.1      0.15   6.7e+02      18      32 ..     559     573 ..     547     588 .. 0.81
   6 ?   -7.7   9.6         4   1.8e+04       3      32 ..     588     612 ..     576     620 .. 0.64
   7 ?    4.9  12.2    0.0066        29       2      41 ..     670     708 ..     662     713 .. 0.69
   8 ?   14.2   0.4   8.1e-06     0.036      13      33 ..    1394    1417 ..    1385    1429 .. 0.81

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3.8
                 TECESBTTTEESTTS-E CS
  Laminin_EGF 17 tgqClCkenveGrkCdr 33
                 + +C C  ++  + C++
   EFC36178.1  5 NEKCTCFVGYVNQYCNE 21
                 668****9999999986 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 4
                  ECESBTTTEESTTS CS
  Laminin_EGF  18 gqClCkenveGrkC 31 
                    C+C +++ G +C
   EFC36178.1 264 DSCSCPNGY-GFDC 276
                  467776554.5555 PP

  == domain 3  score: -6.3 bits;  conditional E-value: 4
                  CCTTTBCC.SSEET....TTECESBTTTEESTTS- CS
  Laminin_EGF   3 Cnphgsss.ssCds....stgqClCkenveGrkCd 32 
                  Cn+  s++ s C      s+  C+C  +++G++C 
   EFC36178.1 281 CNGVLSTDsSVCSGhgtcSSNICSCDSGFSGSDCS 315
                  6666655556666666667799************6 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.003
                  CCTTTBCC.SSEET.....TTECESBTTTEESTTS-E CS
  Laminin_EGF   3 Cnphgsss.ssCds.....stgqClCkenveGrkCdr 33 
                  Cn+  +s+ +sC+s      + +C Ck +++G+ C++
   EFC36178.1 319 CNGILNSNnASCNSnglckYSNTCICKIGYKGTYCNE 355
                  7777666669999999999899*************96 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.15
                  ECESBTTTEESTTS- CS
  Laminin_EGF  18 gqClCkenveGrkCd 32 
                    C+C +++ G++C+
   EFC36178.1 559 NICNCSNGYYGSQCE 573
                  56************8 PP

  == domain 6  score: -7.7 bits;  conditional E-value: 4
                  CCTTTBCCSSEETTTECESBTTTEESTTS- CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCd 32 
                  C+++g    +C+s   +C C  ++  ++C 
   EFC36178.1 588 CSGNG----TCYS-FNNCTCFTGFYDSTCS 612
                  44444....6666.4556666666666653 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.0066
                  -CCTTTBCCSSEETTTECESBTT.....TEESTTS-EE-TTEEEG CS
  Laminin_EGF   2 eCnphgsssssCdsstgqClCke.....nveGrkCdrCkpgyygl 41 
                  +C++hg     C++   +C+C         +G  C++Ckpgyyg+
   EFC36178.1 670 NCSGHG----VCKN--SKCSCYStstagYWTGYWCNQCKPGYYGD 708
                  466666....7776..56666441111146899**********98 PP

  == domain 8  score: 14.2 bits;  conditional E-value: 8.1e-06
                   EET...TTECESBTTTEESTTS-E CS
  Laminin_EGF   13 Cds...stgqClCkenveGrkCdr 33  
                   C++    +g+C+C++++ Gr+Cd 
   EFC36178.1 1394 CQNgydLSGVCKCQDGYIGRNCDI 1417
                   66666679**************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1832 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       926  (0.0516482); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.82u 0.28s 00:00:01.10 Elapsed: 00:00:00.49
# Mc/sec: 11222.99
//
Query:       EFC36179.1  [L=854]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0054   16.8   3.1     0.0077   16.3   0.7    2.5  2  Cnd1             non-SMC mitotic condensation complex subunit
     0.0098   16.1   0.0      0.099   12.9   0.0    2.8  2  HEAT             HEAT repeat
  ------ inclusion threshold ------
      0.057   13.1   4.4        8.6    6.0   0.1    3.7  3  Imm9             Immunity protein 9
      0.059   14.0   3.1       0.12   13.0   0.3    3.0  3  Vac14_Fab1_bd    Vacuolar 14 Fab1-binding region
      0.061   13.8   0.0       0.22   12.1   0.0    2.0  1  HEAT_EZ          HEAT-like repeat
      0.084   13.1   1.8        2.2    8.6   0.0    3.4  3  ACP53EA          Drosophila ACP53EA protein
      0.087   13.2   0.0       0.44   11.0   0.0    2.2  2  HEAT_2           HEAT repeats
        9.9    6.4  10.4        3.3    7.9   0.5    4.1  4  TypeIII_RM_meth  Type III restriction/modification enzyme met


Domain annotation for each model (and alignments):
>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       1.5   3.4e+03      63      96 ..      53      88 ..      45     149 .. 0.52
   2 !   16.3   0.7   3.4e-06    0.0077      16     116 ..     436     545 ..     432     559 .. 0.59

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.5
        Cnd1 63 lakll.eDenprVvanalaalteisek.senaiynl 96
                l ++l +D+++++     ++++e+ +   ++++++ 
  EFC36179.1 53 LSEILqNDDETTITIKIMYIIMEVVKTyPSSKLVEF 88
                445554555566666666666666655422223332 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 3.4e-06
        Cnd1  16 pnlveylvepLrkrLkDedpyVRktaaivvakLilndmvkekg..flselaklleDenprVvanalaalteisek..senaiynllpdiisklsd.... 106
                 +n+ +++++ + + LkDe+  VRkt+ i +++ ++   ++ +   ++ e  k   D+ ++ +++   +l+ +++    +  ++ +  + +s+l +    
  EFC36179.1 436 KNFNDEIIDIMVNNLKDENLNVRKTTCISLSNFLSSREIRPSVfsQIVEYFKYNLDNFRTYSNLITVILKFLHRDnlRDAHTLLIANTFLSNLCEyler 534
                 7899****************************9888777655412333333333444444333333333333333222222233333333333333333 PP

        Cnd1 107 .alnecsewgq 116
                  +l++++ew+ 
  EFC36179.1 535 aNLDQFKEWKV 545
                 33556667665 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.0   4.4e-05     0.099       1      29 [.     442     470 ..     442     472 .. 0.92
   2 ?   -1.7   0.0       2.2     5e+03      12      25 ..     541     554 ..     525     555 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.4e-05
                 HHHHHHHHHT-SSHHHHHHHHHHHHHHHH CS
        HEAT   1 llPlllkllsDpspeVReaAakaLgalae 29 
                 ++++++++l+D++ +VR++++ +L ++++
  EFC36179.1 442 IIDIMVNNLKDENLNVRKTTCISLSNFLS 470
                 688999*******************9986 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 2.2
                 SSHHHHHHHHHHHH CS
        HEAT  12 pspeVReaAakaLg 25 
                 ++++V  ++++ Lg
  EFC36179.1 541 KEWKVLTTCVYYLG 554
                 78999999999998 PP

>> Imm9  Immunity protein 9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.1    0.0038       8.6      23      74 ..     123     174 ..     103     240 .. 0.83
   2 ?    5.4   0.2    0.0062        14      22      66 ..     419     464 ..     410     485 .. 0.83
   3 ?    0.6   0.1      0.17   3.9e+02      15      61 ..     511     563 ..     496     579 .. 0.65

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0038
        Imm9  23 lekyiddlvneikileeLdeWtieivillgkanhigifkkgitdsstkekvl 74 
                  ++ +d   +++ + +e++eW++  ++l  +  h g +   + +s+++ +vl
  EFC36179.1 123 TNETVDTAFKRMSFQNEIPEWKLFTFLLFSRICHRGFYNEFLEYSTESGNVL 174
                 46778888999************99999999999999999999998887776 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0062
        Imm9  22 l.lekyiddlvneikileeLdeWtieivillgkanhigifkkgitd 66 
                 l l++++ + +++i++l++ ++  i i++   k     ++k +   
  EFC36179.1 419 LnLNNQFGEYLEHIQFLKNFNDEIIDIMVNNLKDENLNVRKTTCIS 464
                 3499*************************99998889999977655 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.17
        Imm9  15 elnddkel..lekyiddlvneik..ileeLdeWtie..ivillgkanhigifk 61 
                 +l d + l   + ++++l + ++   l++ +eW+++   v +lg    i+i k
  EFC36179.1 511 NLRDAHTLliANTFLSNLCEYLEraNLDQFKEWKVLttCVYYLGHNISISILK 563
                 5555333322466677776654411355699**98511466777777888877 PP

>> Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1       2.2   4.9e+03      50      76 ..      72      98 ..      57     106 .. 0.69
   2 ?   -2.9   0.0       4.8   1.1e+04      26      39 ..     361     374 ..     356     378 .. 0.81
   3 ?   13.0   0.3   5.5e-05      0.12      21      71 ..     435     487 ..     412     499 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2.2
  Vac14_Fab1_bd 50 slyniakvakgevlkllneifdalvkl 76
                    +  ++k+  ++ l  +   f+++++l
     EFC36179.1 72 IIMEVVKTYPSSKLVEFFPFFEYIIEL 98
                   344567777788888888888888776 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 4.8
  Vac14_Fab1_bd  26 eeivkpvlkcfsDk 39 
                    ++iv++vl++f D 
     EFC36179.1 361 RQIVETVLRSFVDP 374
                    68999999999986 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 5.5e-05
  Vac14_Fab1_bd  21 ikeyleeivkpvlkcfsDkdsrvRyyacEslyni..akvakgevlkllneifd 71 
                    +k++ +ei++++++ ++D++  vR ++c sl n   ++ ++ +v++++ e f+
     EFC36179.1 435 LKNFNDEIIDIMVNNLKDENLNVRKTTCISLSNFlsSREIRPSVFSQIVEYFK 487
                    8999***************************8862257788888888877776 PP

>> HEAT_EZ  HEAT-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   9.6e-05      0.22      28      54 ..     441     467 ..     436     468 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.6e-05
     HEAT_EZ  28 eilpaLlalLnddsdeVRaaAagaLgn 54 
                 ei++ +++ L+d++ +VR+++++ L+n
  EFC36179.1 441 EIIDIMVNNLKDENLNVRKTTCISLSN 467
                 89999********************98 PP

>> ACP53EA  Drosophila ACP53EA protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.12   2.8e+02      16      52 ..     251     286 ..     245     319 .. 0.85
   2 ?   -2.7   0.1         3   6.8e+03      27      62 ..     545     580 ..     543     588 .. 0.61
   3 ?    8.6   0.0   0.00097       2.2      42      82 ..     628     668 ..     611     674 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.12
     ACP53EA  16 sliekaipavkkLakCidfepkkkkelsilrvlkliy 52 
                 ++iek i + ++L++  df+ +++   +i ++l +i 
  EFC36179.1 251 MIIEKLISITYELSEVFDFRFETNI-GDIAKYLSNIG 286
                 6899***************998888.78888888775 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3
     ACP53EA  27 kLakCidfepkkkkelsilrvlkliyqflkklvldk 62 
                  L  C+ +  ++   +  +++l  i++ ++k   +k
  EFC36179.1 545 VLTTCVYYLGHNISISILKDFLDFIKEHIRKFLQQK 580
                 677888886655554445556666666666665444 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00097
     ACP53EA  42 lsilrvlkliyqflkklvldkpkCllktlkeavklvkPfve 82 
                     +++kli  ++   ++++ +Cl++  + +++ v+Pf  
  EFC36179.1 628 EYHESFFKLIDGMFMANIFKNLNCLKEETNIVKDFVQPFLS 668
                 45567899******************************976 PP

>> HEAT_2  HEAT repeats
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0         4   8.9e+03      12      56 ..     356     404 ..     352     407 .. 0.54
   2 ?   11.0   0.0    0.0002      0.44      29      58 ..     439     468 ..     429     480 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 4
      HEAT_2  12 pdpevrraairaLgrignpealpaLvelled....edpavRraaaeaLg 56 
                 p+ ++r+ +  +L ++ +p +  +L+el +d    ed  + ++a++++g
  EFC36179.1 356 PFFNTRQIVETVLRSFVDPYLKILLLELQKDakseEDVLIKETACKSAG 404
                 5555555555556666666554445555444222255567777777665 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.0002
      HEAT_2  29 npealpaLvellededpavRraaaeaLgai 58 
                 n+e+++++v+ l+de+ +vR++ + +L+ +
  EFC36179.1 439 NDEIIDIMVNNLKDENLNVRKTTCISLSNF 468
                 4589***********************977 PP

>> TypeIII_RM_meth  Type III restriction/modification enzyme methylation subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       2.4   5.3e+03      32      45 ..     424     437 ..     422     450 .. 0.59
   2 ?    7.9   0.5    0.0015       3.3       3      27 ..     618     642 ..     617     655 .. 0.86
   3 ?   -2.7   0.0       3.1   6.9e+03       6      32 ..     650     676 ..     647     680 .. 0.78
   4 ?    2.5   0.2     0.071   1.6e+02       9      30 ..     764     785 ..     758     795 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.4
  TypeIII_RM_meth  32 kFaefienkeflpd 45 
                      +F e++e  +fl++
       EFC36179.1 424 QFGEYLEHIQFLKN 437
                      55555555555543 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0015
  TypeIII_RM_meth   3 eLlklLlkneeikehFfeevdgvlv 27 
                      +Ll+l  +++e +e Ff+ +dg++ 
       EFC36179.1 618 DLLHLFASKKEYHESFFKLIDGMFM 642
                      79********************964 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3.1
  TypeIII_RM_meth   6 klLlkneeikehFfeevdgvlvFdkek 32 
                      + L ++ +i + F++   +  +F+k +
       EFC36179.1 650 NCLKEETNIVKDFVQPFLSNYLFEKVQ 676
                      567778888999999888888888876 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.071
  TypeIII_RM_meth   9 lkneeikehFfeevdgvlvFdk 30 
                      l+ +++ + F+++vd+ ++Fd 
       EFC36179.1 764 LNIDDVAQIFVDHVDDFFLFDD 785
                      456889999***********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (854 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1037  (0.0578393); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.82u 0.36s 00:00:01.18 Elapsed: 00:00:00.56
# Mc/sec: 4576.05
//
Query:       EFC36180.1  [L=323]
Description: hypothetical protein NAEGRDRAFT_82289 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.5e-05   23.1   0.2      0.018   15.2   0.0    2.2  2  GWT1          GWT1
    0.00051   19.1   0.2       0.34    9.8   0.0    2.1  2  MFS_1         Major Facilitator Superfamily
     0.0023   17.6   0.4       0.28   10.8   0.1    2.2  2  SUR7          SUR7/PalI family
     0.0025   17.6   5.9       0.07   12.9   0.4    2.3  2  BPD_transp_1  Binding-protein-dependent transport system inne
     0.0025   17.8   0.6       0.21   11.7   0.1    2.7  2  CrgA          Cell division protein CrgA
     0.0053   15.6   0.2      0.039   12.8   0.0    2.0  2  Otopetrin     Otopetrin
     0.0069   16.4   9.5       0.24   11.4   1.0    2.1  2  Colicin_V     Colicin V production protein
  ------ inclusion threshold ------
       0.02   14.5   6.8        4.9    6.7   4.8    3.4  3  SARAF         SOCE-associated regulatory factor of calcium ho
       0.19   12.0   0.0       0.19   12.0   0.0    3.7  4  Orf78         Orf78 (ac78)
       0.35   11.0   0.1       0.35   11.0   0.1    3.2  3  PspB          Phage shock protein B
       0.57   10.3   6.1        9.9    6.3   1.3    2.3  2  DUF3671       Protein of unknown function


Domain annotation for each model (and alignments):
>> GWT1  GWT1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   1.1e-05     0.018      37     109 ..      61     146 ..      19     179 .. 0.68
   2 !    6.0   0.1    0.0073        12      22     102 ..     224     311 ..     214     322 .. 0.49

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.1e-05
        GWT1  37 e..........kkkkkkkkesketlkllikllllsilllllllllelyvef..vSRrlaNlpYvlwvvalnltllllflliel.lf 109
                              + +kkk+   tl l+i  l++ +++++l+++++ ++++   +R l N++  l+v+++ ++ +++++++ + + 
  EFC36180.1  61 YysggyvqphyDDQYHKKKNDDMTLLLFIVGLFIPLVWIVLFFITRDKTKYsnRARTLGNVGCGLIVASIICYAVFIVIIVAVnIA 146
                 03333444434334445566666666777777888999999999999999977799***************999999998877333 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0073
        GWT1  22 lgkyvlkrekeaeeee....kkkkkkkkesketlkllikllllsilllllllllelyvef..vSRrlaNlp...Yvlwvvalnltllllf 102
                  g+ ++++++++ ++     + + kkk++   ++ ++   +++ i++l+l+ +++  +++    Rr+ N++   + ++vv l +++++l+
  EFC36180.1 224 PGQTTTQQTTTFVSNPvlgdNFDLKKKNDDMAFV-IFLIGFCFPIIWLILFAMTRNRMNYsdRGRRFGNIGgglFACFVV-LDIAVVILI 311
                 3444443333333333665433332333333333.344444556677777777787788866799999997332333322.223333333 PP

>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.0   0.00021      0.34      90     143 ..      85     138 ..      69     154 .. 0.65
   2 !    7.6   0.1   0.00096       1.6      89     249 ..     255     296 ..     178     321 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00021
       MFS_1  90 vlrvlqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggl 143
                 +l ++ Gl+  +++ +   +++d ++ ++r+r +g ++ g  +++i+ +++  +
  EFC36180.1  85 LLLFIVGLFIPLVWIVLFFITRDKTKYSNRARTLGNVGCGLIVASIICYAVFIV 138
                 455566666666666666666666666666666666666666666555444333 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00096
       MFS_1  89 lvlrvlqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggllasslgWravfyilaivsllafvlfllllpeepperkrkspkee 187
                 +++ +l G+                                                                                          
  EFC36180.1 255 AFVIFLIGF------------------------------------------------------------------------------------------ 263
                 333334444.......................................................................................... PP

       MFS_1 188 ekgtgpaplvpawkallkdpvlwillialllfffgfsglltllplylqevlgls...........glllagll 249
                                                   +f ++   l+ +++ ++++s           g      l
  EFC36180.1 264 ----------------------------------CFPIIWLILFAMTRNRMNYSdrgrrfgniggG------L 296
                 ..................................44444444444445555555554444222221......2 PP

>> SUR7  SUR7/PalI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.0    0.0088        14     114     166 ..      83     143 ..      31     148 .. 0.75
   2 !   10.8   0.1   0.00017      0.28     112     178 ..     252     321 ..     213     323 .] 0.72

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0088
        SUR7 114 alfilhiialvlsfislvvgllaicvspdnsrl........lsflnlllsvlsflatllaa 166
                 + + l+i++l++ ++ +v+ ++    +++++r+        ++++++++  ++f+++++a+
  EFC36180.1  83 MTLLLFIVGLFIPLVWIVLFFITRDKTKYSNRArtlgnvgcGLIVASIICYAVFIVIIVAV 143
                 5677888888888887777777776666666644555555588888888888888888775 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00017
        SUR7 112 tkalfilhiialvlsfislvv.gllai.cvspdnsrllsflnl.llsvlsflatllaalldtllfvfvrk 178
                   ++f++++i++++ +i l++ +++ + +   d  r++ ++   l++ +++l +++  l+++l  v+vr+
  EFC36180.1 252 DDMAFVIFLIGFCFPIIWLILfAMTRNrMNYSDRGRRFGNIGGgLFACFVVLDIAVVILIVVLNNVVVRR 321
                 4579*************66653666664444444445555544699999999999999999888888875 PP

>> BPD_transp_1  Binding-protein-dependent transport system inner membrane component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.4   4.3e-05      0.07      11      75 ..      75     148 ..      71     157 .. 0.79
   2 !    7.2   0.7    0.0024       3.9      13      70 ..     248     321 ..     240     323 .] 0.73

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.3e-05
  BPD_transp_1  11 nrnkkldkllrpliivllslPsfvlaillvlvf........vilsilg.hlilpviillllsaapyvrlirraa 75 
                   +++kk d++ + l+iv+l +P ++++++++             l+ +g  li + ii+++++++++v ++++++
    EFC36180.1  75 YHKKKNDDMTLLLFIVGLFIPLVWIVLFFITRDktkysnraRTLGNVGcGLIVASIICYAVFIVIIVAVNIARM 148
                   67899999****************9999886669*999888666777734445578888888888888777766 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0024
  BPD_transp_1  13 nkkldkllrpliivllslPsfvlaillvlvf..................vilsilghlilpviillllsaapyvrl 70 
                   +kk d++  +++ +++++P+++  ++l+++                    ++  +  l ++v+il+++ +  +vr+
    EFC36180.1 248 KKKNDDMAFVIFLIGFCFPIIW--LILFAMTrnrmnysdrgrrfgniggGLFACFVVLDIAVVILIVVLNNVVVRR 321
                   6777888899999999999999..4444556678887777777777777666667777888888888877777775 PP

>> CrgA  Cell division protein CrgA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.1   0.00013      0.21      26      81 ..      76     130 ..      50     140 .. 0.69
   2 ?    4.1   0.1      0.03        50      28      60 ..     249     281 ..     227     314 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00013
        CrgA  26 aakpsprwyvpvmlglmllGllwlvvyYlageeipfmaelgawNlliGfgliivGl 81 
                 ++k++  +   +++  + + l+w+v+++++++++++ +   +    +G gli++++
  EFC36180.1  76 HKKKNDDMTLLLFIVGLFIPLVWIVLFFITRDKTKYSNRARTL-GNVGCGLIVASI 130
                 34556666666666667789************88854433322.235666666655 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.03
        CrgA  28 kpsprwyvpvmlglmllGllwlvvyYlageeip 60 
                 k++  +  +++l  + + ++wl+++ +++++++
  EFC36180.1 249 KKNDDMAFVIFLIGFCFPIIWLILFAMTRNRMN 281
                 556666667777778889999999999998776 PP

>> Otopetrin  Otopetrin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   2.4e-05     0.039     249     305 ..      87     144 ..      15     161 .. 0.84
   2 ?    0.9   0.2     0.094   1.5e+02     251     304 ..     260     315 ..     224     322 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.4e-05
   Otopetrin 249 lglLllvltiislilFfvlvrkpklsslailladl.selvllalaiiaviigfirvrk 305
                 l ++ l + ++ ++lFf+  +k k+s+ a +l ++ + l++ +++  av+i +i++ +
  EFC36180.1  87 LFIVGLFIPLVWIVLFFITRDKTKYSNRARTLGNVgCGLIVASIICYAVFIVIIVAVN 144
                 2333444567899*********************999999888888888888777655 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.094
   Otopetrin 251 lLllvltiislilFfvlvrkpklsslailladl..selvllalaiiaviigfirvr 304
                 l+ + + ii lilF +  ++ ++s+      ++    ++ +++  iav+i ++++ 
  EFC36180.1 260 LIGFCFPIIWLILFAMTRNRMNYSDRGRRFGNIggGLFACFVVLDIAVVILIVVLN 315
                 35578899999999999999999887766666633333444444555555555555 PP

>> Colicin_V  Colicin V production protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   1.9    0.0006      0.97      65     125 ..      85     147 ..      82     159 .. 0.76
   2 !   11.4   1.0   0.00015      0.24      57     118 ..     252     313 ..     226     321 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0006
   Colicin_V  65 lllfllvlli..vsllgallsklvsktglglldrllG.aifGllkglllvv.llllllalvplpk 125
                 lllf+++l+i  v+++  +++  ++kt  ++  r+lG +  Gl+ + ++++ ++++++ +v++ +
  EFC36180.1  85 LLLFIVGLFIplVWIVLFFIT--RDKTKYSNRARTLGnVGCGLIVASIICYaVFIVIIVAVNIAR 147
                 688888888853444444444..499*****9999995569**********88888887777665 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00015
   Colicin_V  57 alaaiiaflllfllvllivsllgallsklvsktglglldrllGaifGllkglllvvllllll 118
                   +a++ fl+ f++ ++ + l+++  +++    + +++ ++ G++f ++ +l ++v++l+++
  EFC36180.1 252 DDMAFVIFLIGFCFPIIWLILFAMTRNRMNYSDRGRRFGNIGGGLFACFVVLDIAVVILIVV 313
                 4456788888888888888888888888889999******************9999666443 PP

>> SARAF  SOCE-associated regulatory factor of calcium homoeostasis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.4      0.74   1.2e+03     193     222 ..      22      52 ..       3      72 .. 0.38
   2 ?    6.7   4.8     0.003       4.9     160     230 ..     118     191 ..      31     233 .. 0.65
   3 ?    3.1   0.0     0.038        62     150     194 ..     238     287 ..     214     298 .. 0.60

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.74
       SARAF 193 ggrrgegggggggggg.pgseeeqddpPppy 222
                   + ++ +++++ ++  p+++ + d+pP   
  EFC36180.1  22 YYTPQQYPQYNTTTTAtPQYDPYADQPPVAA 52 
                 2222222222222111122333323333333 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.003
       SARAF 160 asll.fvvlvllviayivykaflaaeeereaeaeggrrgegggggggggg..pgseeeqddpPppysltksqkp 230
                 ++ +   ++v+ +i+y v+ +++ a +  +  ++++   +++ +++++    ++++ + d+pPp+y++t++q+p
  EFC36180.1 118 LGNVgCGLIVASIICYAVFIVIIVAVNIARMDPSMQVPLHQPLQEQAKYAgeEKYNYYYDQPPPYYTTTTPQYP 191
                 33333455566666666666655444444444444444444443333332113334444999999965555554 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.038
       SARAF 150 e.......vkkksssssasllfvvlvllviayivykaflaaeee.reaeaegg 194
                 +         kk+++++a ++f++ +++ i++ +  a+++++ + +++   g+
  EFC36180.1 238 NpvlgdnfDLKKKNDDMAFVIFLIGFCFPIIWLILFAMTRNRMNySDR---GR 287
                 145555544456666677777888888888888887777665553222...22 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   0.00012      0.19      57      98 ..      73     114 ..      12     119 .. 0.72
   2 ?   -0.9   0.7       1.3   2.1e+03      71      84 ..     128     141 ..     120     157 .. 0.57
   3 ?    1.7   0.0       0.2   3.2e+02      55      92 ..     238     279 ..     200     290 .. 0.54
   4 ?   -1.7   1.8       2.2   3.6e+03      74      84 ..     305     314 ..     291     322 .. 0.46

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00012
       Orf78  57 aekaqalnillisllavvcvlvllyviyYfvilrerqkssvk 98 
                  + ++++n  ++ ll +v +++ l  i+ f+i+r+++k+s++
  EFC36180.1  73 DQYHKKKNDDMTLLLFIVGLFIPLVWIVLFFITRDKTKYSNR 114
                 33333334445667788889999999999*********9985 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.3
       Orf78  71 lavvcvlvllyviy 84 
                  +++c  v + +i+
  EFC36180.1 128 ASIICYAVFIVIIV 141
                 23333333333333 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.2
       Orf78  55 n.......aaekaqalnillisllavvcvlvllyviyYfvilrer 92 
                 n       + +k++   +++i l+  +c  ++  +   f ++r+r
  EFC36180.1 238 NpvlgdnfDLKKKNDDMAFVIFLIG-FCFPIIWLI--LFAMTRNR 279
                 1444444434444444444444443.343333222..24455555 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 2.2
       Orf78  74 vcvlvllyviy 84 
                 ++v++l+ v++
  EFC36180.1 305 IAVVILI-VVL 314
                 2333333.333 PP

>> PspB  Phage shock protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   0.00021      0.35       7      32 ..      85     110 ..      80     116 .. 0.86
   2 ?   -3.4   1.7       6.4     1e+04       7      19 ..     128     140 ..     124     144 .. 0.57
   3 ?    4.4   0.1     0.025        40       8      32 ..     258     281 ..     252     284 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00021
        PspB   7 vpliifvlfVapiWLiLHYrskkkrs 32 
                  +l i+ lf+ ++W++L+++++ k++
  EFC36180.1  85 LLLFIVGLFIPLVWIVLFFITRDKTK 110
                 5788999**************99876 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 6.4
        PspB   7 vpliifvlfVapi 19 
                 + +i++ +f+++i
  EFC36180.1 128 ASIICYAVFIVII 140
                 5555555555544 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.025
        PspB   8 pliifvlfVapiWLiLHYrskkkrs 32 
                 +  i + f  +iWLiL+ +++++++
  EFC36180.1 258 IFLIGFCF-PIIWLILFAMTRNRMN 281
                 22232222.458*****99998875 PP

>> DUF3671  Protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   1.3    0.0061       9.9      44     108 ..      83     141 ..      67     148 .. 0.46
   2 ?    6.1   0.2    0.0069        11      53     109 ..     257     313 ..     243     317 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0061
     DUF3671  44 yglllilpvllpliglivpi.lfeakskkslkkkelevlatsieklytiffiilvviillvliYil 108
                 + lll+++ l+  ++ iv+  +   k k s+++        ++ ++ + +++ +++++ +++++i+
  EFC36180.1  83 MTLLLFIVGLFIPLVWIVLFfITRDKTKYSNRA-------RTLGNVGCGLIVASIICYAVFIVIIV 141
                 444555444444444343330333333333333.......44555555555555555544433332 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0069
     DUF3671  53 llpliglivpilfeakskkslkkkelevlatsieklytiffiilvviillvliYili 109
                 +++lig+ +pi+  +    + +  + +     + ++   +f  +vv  + v+i i++
  EFC36180.1 257 VIFLIGFCFPIIWLILFAMTRNRMNYSDRGRRFGNIGGGLFACFVVLDIAVVILIVV 313
                 445555555554444333444455555567889999999999999999999998864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1209  (0.0674327); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.69u 0.36s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 1874.81
//
Query:       EFC36181.1  [L=119]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0074   15.9   3.3      0.016   14.8   3.3    1.6  1  DUF3755   Protein of unknown function (DUF3755)
  ------ inclusion threshold ------
      0.011   15.8   1.5      0.017   15.1   1.2    1.4  1  DUF489    Protein of unknown function (DUF489)
      0.016   15.6   3.5      0.021   15.2   3.5    1.2  1  Muted     Organelle biogenesis, Muted-like protein
      0.066   13.2   1.0      0.079   13.0   1.0    1.2  1  PilJ      Type IV pili methyl-accepting chemotaxis transducer
       0.27   11.6   4.6       0.49   10.8   4.6    1.5  1  LPP20     LPP20 lipoprotein
        2.7    8.3   6.4        6.1    7.2   4.2    2.1  2  DUF948    Bacterial protein of unknown function (DUF948)


Domain annotation for each model (and alignments):
>> DUF3755  Protein of unknown function (DUF3755)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   3.3   5.3e-06     0.016       3      25 ..      56      78 ..      55      89 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.3e-06
     DUF3755  3 klqeNidLFcqtRdNImaIlndM 25
                klq+N +LF+q ++ + ++++++
  EFC36181.1 56 KLQDNANLFNQINNSLFKLQKEL 78
                9***************9999885 PP

>> DUF489  Protein of unknown function (DUF489)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   1.2   5.7e-06     0.017      40     123 ..       4      91 ..       1     102 [. 0.82

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 5.7e-06
                 -S-SSHHHHTTS...GGGGHHHHHHHHHHHHT--SCHHHHHHHHHHHHHHHHHHHHHSTTHHHHHHHHHHTTHHHHT.TS.-TTSHHHH CS
      DUF489  40 tdpestedvygg...lanlklGletlleqlekekkkkdaeltryalsllalerkLsknkealaklgerieqierqle.hf.dllhenvl 123
                 ++p+s + v+     +a+l+ G + ++ q ++ ++   +++t ++ + l+ e kL+ n ++++++++++ +++++l+ ++ + ++++++
  EFC36181.1   4 QEPTSHQVVFTPlqlPADLTPGTSYVEYQQNQWTT-IMTNTTALVSKSLETEAKLQDNANLFNQINNSLFKLQKELDpNNvKTMKTQLV 91 
                 677888888876556789999*9999999888887.78899**********************************99433356666555 PP

>> Muted  Organelle biogenesis, Muted-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   3.5   6.9e-06     0.021      29      85 ..      51     108 ..      31     112 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 6.9e-06
       Muted  29 FEekRgdrevelL.enikklvnelkeqllpkclesmkenLselnkkleaalekverll 85 
                 +E+    ++  +L ++i++ + +l+++l p+++++mk++L +++++le++  ++e ++
  EFC36181.1  51 LETEAKLQDNANLfNQINNSLFKLQKELDPNNVKTMKTQLVNIQQQLEKVIRMTESVE 108
                 555555555555516799*********************************9999886 PP

>> PilJ  Type IV pili methyl-accepting chemotaxis transducer N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   1.0   2.6e-05     0.079      28      95 ..      41     111 ..      32     119 .] 0.81

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.6e-05
        PilJ  28 keallaaagaydaaearaqlretiaqfdrtlaalrlg.dpapgllvpae...avraqleaveqlWqelkkpa 95 
                 ++++++   + +++++ ++ ++  +q++++l  l++  dp+ +++++++   ++++qle+v++  +  ++ +
  EFC36181.1  41 TNTTALVSKSLETEAKLQDNANLFNQINNSLFKLQKElDPN-NVKTMKTqlvNIQQQLEKVIRMTESVEDLL 111
                 45566666668999999999**************9995555.89999999***********99988888777 PP

>> LPP20  LPP20 lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   4.6   0.00016      0.49      30      80 ..      54     107 ..      24     109 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00016
       LPP20  30 nAlrdiaeqiqvqvkss.sstqets..aavqnsettnesvsqvvesvlrgieiv 80 
                 +A  +  ++++ q+++s +++q+++  ++v +++t+   ++q +e+v+r +e v
  EFC36181.1  54 EAKLQDNANLFNQINNSlFKLQKELdpNNVKTMKTQLVNIQQQLEKVIRMTESV 107
                 444455555555555441556555599**********************99876 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.8     0.039   1.2e+02      39      75 ..      33      65 ..      26      79 .. 0.63
   2 ?    7.2   4.2     0.002       6.1      27      80 ..      56     110 ..      43     111 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.039
      DUF948 39 ekqvdpilkevedllakvnelledvneklekvdplte 75
                ++q + i++++++l++k+ e+    + kl++  +l++
  EFC36181.1 33 QNQWTTIMTNTTALVSKSLET----EAKLQDNANLFN 65
                567778888888888888773....333333333333 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.002
      DUF948  27 tldeaaatieelekqvdpilkeve.dllakvnelledvneklekvdplteavadl 80 
                  l+ +a+  +++++ + ++ ke++ + ++++++ l +++++lekv ++te+v+dl
  EFC36181.1  56 KLQDNANLFNQINNSLFKLQKELDpNNVKTMKTQLVNIQQQLEKVIRMTESVEDL 110
                 4566666677777777777777763345555666778999***********9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1959  (0.109264); expected 358.6 (0.02)
Passed bias filter:                      586  (0.0326845); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 735.25
//
Query:       EFC36182.1  [L=307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-30  105.8   0.3    9.3e-27   93.7   0.1    2.1  2  adh_short        short chain dehydrogenase
    4.8e-15   55.7   0.0    2.7e-14   53.3   0.0    1.9  2  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
      5e-10   39.6   0.1    8.8e-10   38.8   0.1    1.5  1  KR               KR domain
     0.0002   20.9   0.0    0.00028   20.4   0.0    1.2  1  Epimerase        NAD dependent epimerase/dehydratase family
     0.0015   18.0   0.0     0.0027   17.2   0.0    1.5  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
     0.0021   17.2   0.0     0.0031   16.7   0.0    1.2  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
     0.0028   17.6   0.0     0.0051   16.7   0.0    1.5  1  NAD_binding_10   NAD(P)H-binding
     0.0082   16.2   0.0      0.015   15.3   0.0    1.4  1  Shikimate_DH     Shikimate / quinate 5-dehydrogenase
  ------ inclusion threshold ------
       0.13   12.2   0.2       0.46   10.5   0.2    1.8  2  ADH_zinc_N       Zinc-binding dehydrogenase
       0.13   11.6   0.1        3.9    6.7   0.0    2.2  2  YPEB             YpeB sporulation


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.7   0.1   5.2e-30   9.3e-27       1     138 [.      19     158 ..      19     165 .. 0.92
   2 !   10.2   0.0   0.00021      0.37     144     188 ..     180     230 ..     176     233 .. 0.78

  Alignments for each domain:
  == domain 1  score: 93.7 bits;  conditional E-value: 5.2e-30
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT....TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGG CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee....gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfse 95 
                 kvv++tGas+GIG+a + +l+++Ga+v+++ rse+k+ +v++e++++     a + +i++D++d e+v+++ +k  +k  ++++Lv NAG+   +   +
  EFC36182.1  19 KVVIITGASDGIGKAAVTHLVEMGAHVILACRSEDKAMKVMEEIRNKtankDAMMQFIPLDLSDLESVRNFARKFLEKNLPIHALVCNAGV--WEVERK 115
                 89*******************************************998754455899**********************************..344455 PP

                 CSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGG CS
   adh_short  96 lseeewervievNltgvflltravlpamlkqssGrIvnvsSva 138
                  +++++e+++ +N  g fll+ ++l++++++   rI+  sS +
  EFC36182.1 116 KTKQQFENTYGINHLGHFLLVNLLLDKLKESAPSRIIILSSKI 158
                 67788************************************86 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00021
                 TTBHHHHHHHHHHHHHHHHHHHHHGGGT......EEEEEEEESSBSSHHHH CS
   adh_short 144 agvaaYsAsKaavagltrslakelaptg......irvnavaPGlvdTdmak 188
                  g   Y+ sK a   ++ +l + l++ +      ++v+a++PG+v+T++ +
  EFC36182.1 180 SGKQTYANSKLANLLFAYKLVRNLNEGSsipqsgVSVIAMHPGVVNTQIFA 230
                 5677899999999999988888877544444445*************9865 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.3   0.0   1.5e-17   2.7e-14       1     129 [.      25     157 ..      25     166 .. 0.91
   2 ?    0.1   0.0      0.28     5e+02     160     183 ..     210     233 ..     179     241 .. 0.80

  Alignments for each domain:
  == domain 1  score: 53.3 bits;  conditional E-value: 1.5e-17
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE.E....EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH- CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgae.v....lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpflets 91 
                   Ga  gIG+a++ +l e Ga+v+l+ ++e++  k +ee+ +++ ++ +    +++D +d e+v++++++  ek   ++ lv nag+ +   ++  + +
    EFC36182.1  25 GASDGIGKAAVTHLVEMGAHVILACRSEDKaMKVMEEIRNKTANKdAmmqfIPLDLSDLESVRNFARKFLEKNLPIHALVCNAGVWEV--ER--KKT 117
                   899***************************99999***9999866533678************************************9..33..569 PP

                   HHHHHHHHHHHTHHHHHHHHHHHHHCTSC..CEEEEEEEG CS
  adh_short_C2  92 reefdraldvnlyslfllakaalplmkeg..gsivnlssv 129
                   +++f+++  +n  + fll++ +l  +ke+  ++i+ lss 
    EFC36182.1 118 KQQFENTYGINHLGHFLLVNLLLDKLKESapSRIIILSSK 157
                   9***********************888888999***9995 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.28
                   GGGTEEEEEEEE--BHCTGGGGST CS
  adh_short_C2 160 gpkgiRvNavspgpikTlaasgik 183
                    + g+ v a +pg+++T++ +g+ 
    EFC36182.1 210 PQSGVSVIAMHPGVVNTQIFAGLL 233
                   56899999*********9988765 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.8   0.1   4.9e-13   8.8e-10       3     121 ..      21     137 ..      19     168 .. 0.78

  Alignments for each domain:
  == domain 1  score: 38.8 bits;  conditional E-value: 4.9e-13
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HH.HHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE---------TTT- CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaaded.skaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvlrdklleem 100
                 ++itG+  g+G++ +++l+e ga h++l  Rs+ +  + +++  ++ ++++a  +++++D+sd ++v++  +++ +++ pi+  +  Agv + +   ++
  EFC36182.1  21 VIITGASDGIGKAAVTHLVEMGA-HVILACRSEDKAMKvMEEIRNKTANKDAMMQFIPLDLSDLESVRNFARKFLEKNLPIHALVCNAGVWEVE--RKK 116
                 79********************8.5667777754444404444455666799**************************************9876..467 PP

                 -HHHHHHHHTTTTHHHHHHHH CS
          KR 101 taedleqvlapKvkGawnLhe 121
                 t++++e+ +     G   L +
  EFC36182.1 117 TKQQFENTYGINHLGHFLLVN 137
                 777777776666555555555 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   1.6e-07   0.00028       1     152 [.      21     195 ..      21     214 .. 0.69

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.6e-07
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC...........EEEE--TT-HHHHH....HHHHHH.T-SEEEE--S---HHHHH.. CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl...........elveldltdrsale....rlfkee.qpdavihlAavggvaass.. 81 
                 +++tGa+  iG+a v +l e g +vi   r +++  +   e++           +++ ldl d ++++    ++++++  ++a +  A+v  v+++   
  EFC36182.1  21 VIITGASDGIGKAAVTHLVEMGAHVILACRSEDKAMK-VMEEIrnktankdammQFIPLDLSDLESVRnfarKFLEKNlPIHALVCNAGVWEVERKKtk 118
                 68********************887777777444433.3333457899*****************8871111455556444444444556655554400 PP

                 HSHHHHHHHHTHHHHHHHHHHH....HHTCTEEEEEEE.GGGGTSCSS...SS.BSTCSTTS----SSHHHHHHHHHHHH CS
   Epimerase  82 edpadfieknlqgtlnlleaar....kagvkrllflsS.sevYGkdae...qp.keettltgplkpnspYaaaKlagekl 152
                 ++ + ++ +n  g   l++ +     ++ + r++ lsS  +  G+ +e    p  e+    +++   + Ya +Kla    
  EFC36182.1 119 QQFENTYGINHLGHFLLVNLLLdklkESAPSRIIILSSkIHSSGDAKEllsDPnYEKP---SSYSGKQTYANSKLANLLF 195
                 4557888899888887777777333255666******955666777777633644444...48899999*****986544 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   1.5e-06    0.0027       2     158 ..      23     190 ..      22     220 .. 0.61

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.5e-06
                    EETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHH.....T-SEEEE--S---HHHHT CS
  GDP_Man_Dehyd   2 iTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaev.....qpdevynLAAqshVdvsf 92 
                    iTG +  iG   + +L+e g +v+  +r s+  +++ +e+++++  ++++  ++++  Dl+D +s+++  ++       +++ +  A+   V+++ 
     EFC36182.1  23 ITGASDGIGKAAVTHLVEMGAHVILACR-SEDKAMKVMEEIRNKT-ANKDAMMQFIPLDLSDLESVRNFARKFleknlPIHALVCNAGVWEVERKK 116
                    9999999****************87665.5555789999998655.56789************999987666532111223333333333443332 PP

                    ..TSHHHHHHHHTHHHHHHHHHHH.HCT..TTSEEEEEEEG.GGG-S-SS...SSB-TT.S-----SHHHHHHH CS
  GDP_Man_Dehyd  93 ..ekPeytaevnvlGtlrLLeair.alglekkvrfyqaSts.EvYGkvqe...vpqtEt.tpfyPrsPYaaaKl 158
                      ++ e t+ +n lG + L+++   +l+ +   r+++ S+     G+++e    p  E+   ++ +  Ya +Kl
     EFC36182.1 117 tkQQFENTYGINHLGHFLLVNLLLdKLKESAPSRIIILSSKiHSSGDAKEllsDPNYEKpSSYSGKQTYANSKL 190
                    11455666666666666666655413343444555555554234466654111333343244556666666665 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   1.7e-06    0.0031       1      75 [.      21      92 ..      21     128 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.7e-06
                     EEEETTTSHHHHHHHHHHHHHB-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT. CS
  Polysacc_synt_2  1 vlvtGagGsiGselvrqilkkkpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrdkerlekalee 75
                     v++tGa+  iG++ v++++++ ++ +il  r+E k +++ +e+++++++k+  ++   +  d+ d e++++  ++
       EFC36182.1 21 VIITGASDGIGKAAVTHLVEMGAH-VILACRSEDKAMKVMEEIRNKTANKDAMMQ--FIPLDLSDLESVRNFARK 92
                     79*****************99875.677778888888888887777777666455..444577777777766654 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.9e-06    0.0051       1     142 [.      25     201 ..      25     228 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.9e-06
                     TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCH.........HHHCTTTCEEEE--TT-CCHHHHHHT.......T-SEEEES-....--TCCHH CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRnpekla.........eleaeeglevvegdvtdvedlaealk.......gadaVvsal....ggggkde 75 
                     GA+ ++G+++v++l++ g  +v +  R+++k+             +++ ++ + +d++d e++++  +        + a v+++      ++k++
      EFC36182.1  25 GASDGIGKAAVTHLVEMG-AHVILACRSEDKAMkvmeeirnkTANKDAMMQFIPLDLSDLESVRNFARkfleknlPIHALVCNAgvweVERKKTK 118
                     99***************5.9*********9996444434332222456788999*****999999888777777777888888856652333333 PP

                     HH...............HHHHHHHHHHCT--EEEEEEE.TTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEEEEEE CS
  NAD_binding_10  76 eg...............aknivdaakeagvkRfvlvsa.igvgdevpgefgewnkellkaylaakraaeellrasgldwTivr 142
                     ++               ++ ++d +ke+  +R++++s+ i++  ++++ +++ n+e  ++y  ++++a   l +  + +  vr
      EFC36182.1 119 QQfentyginhlghfllVNLLLDKLKESAPSRIIILSSkIHSSGDAKELLSDPNYEKPSSYSGKQTYANSKLANLLFAYKLVR 201
                     3357778999999999899999***********99998788888889999999999999888888888777776655555555 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   8.6e-06     0.015      11      64 ..      16      70 ..       8      79 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 8.6e-06
                  TT-EEEEE.S-SH.HHHHHHHHHHCCT-CEEEEEESSHHHHHHHHHHHT.ET-EEE CS
  Shikimate_DH 11 kekkvlli.GaGe.maelvakhLlakgvkkvvvaNRtlerakelaeelkgeeieal 64
                  k+ kv++i Ga   +++ +++hL++ g++ v+ a R+ ++a ++ ee++++ ++  
    EFC36182.1 16 KGDKVVIItGASDgIGKAAVTHLVEMGAH-VILACRSEDKAMKVMEEIRNKTANKD 70
                  5555555548875488999*********9.******************88855554 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.2   0.00025      0.46       1      32 [.      29      60 ..      29      67 .. 0.94
   2 ?   -1.8   0.0       1.6   2.8e+03      86     120 ..     256     293 ..     253     298 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00025
                HHHHHHHHHHHHTT-EEEEEESSHHHHHHHHH CS
  ADH_zinc_N  1 gvGlaavqlAkalGaeviavdsseeklelakk 32
                g+G aav  +  +Ga+vi +++se+k+ ++++
  EFC36182.1 29 GIGKAAVTHLVEMGAHVILACRSEDKAMKVME 60
                8************************9988775 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.6
                 EECSC.TSSEEE..EEHHHHHHTT-EEEEE-SSCHHHH CS
  ADH_zinc_N  86 vvvGg.gkgeee..fdlrnlllkeksilGsllgslree 120
                 v+ ++ + ++ +  f+ + +++++ksi  s+  +++++
  EFC36182.1 256 VFHAVhPDQNGVtgFKYYEQWKEKKSIADSFNEKYQDD 293
                 56666544444447888889999999988887776655 PP

>> YPEB  YpeB sporulation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.0    0.0022       3.9      49      92 ..      47      90 ..      38      95 .. 0.90
   2 ?    2.5   0.0     0.043        77       5      35 ..     268     298 ..     266     305 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0022
        YPEB 49 lavnsreqnskllaevwrqaseAqenlgqLPlstlelsktekFL 92
                la+ s+ +++k+++e+ +++++  + ++ +Pl   +l+ + +F 
  EFC36182.1 47 LACRSEDKAMKVMEEIRNKTANKDAMMQFIPLDLSDLESVRNFA 90
                7999**********************************999995 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.043
        YPEB   5 vgvwgykqyqeknaleieleneyqrafhdLv 35 
                 +g+  y+q +ek++++ +++++yq ++ +++
  EFC36182.1 268 TGFKYYEQWKEKKSIADSFNEKYQDDLWEMS 298
                 6777899********************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       785  (0.0437838); expected 358.6 (0.02)
Passed bias filter:                      682  (0.0380389); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 1909.35
//
Query:       EFC36183.1  [L=181]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       837  (0.0466841); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.33s 00:00:00.88 Elapsed: 00:00:00.54
# Mc/sec: 1009.99
//
Query:       EFC36184.1  [L=813]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.6e-06   27.7   0.0    6.4e-06   26.4   0.0    1.7  1  HAMP             HAMP domain
    1.1e-05   25.6   0.1    2.3e-05   24.6   0.1    1.6  1  CHASE4           CHASE4 domain
  ------ inclusion threshold ------
      0.011   16.0   1.6      0.011   16.0   1.6    2.9  3  RGS              Regulator of G protein signaling domain
      0.027   13.6   3.8      0.051   12.7   0.4    2.5  2  AI-2E_transport  AI-2E family transporter
      0.076   12.8   0.0       0.26   11.1   0.0    1.9  1  TMEM132D_C       Mature oligodendrocyte transmembrane protein
       0.17   11.6   6.3        1.9    8.2   0.2    2.6  3  Tetraspanin      Tetraspanin family
       0.19   12.2   7.0        1.7    9.1   0.5    3.1  2  Snapin_Pallidin  Snapin/Pallidin
        1.4    9.2   5.5        9.6    6.5   0.5    2.4  2  HemY_N           HemY protein N-terminus
        1.8    8.7   6.6        1.4    9.0   1.5    2.6  2  DHHC             DHHC palmitoyltransferase
        5.5    7.3   9.4       0.58   10.5   0.4    3.3  3  Orf78            Orf78 (ac78)
        7.4    6.3  10.6       0.22   11.3   1.4    2.7  3  DUF724           Protein of unknown function (DUF724)


Domain annotation for each model (and alignments):
>> HAMP  HAMP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.0   3.9e-09   6.4e-06       4      52 ..     423     473 ..     420     474 .. 0.91

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 3.9e-09
                 HTTHHHHHHHHHHHHHHTT.T.BTSSTCCTTSSSHHHHHHHHHHHHHHHHH CS
        HAMP   4 rrilrPLrrLaraarriaa.G.dldtrlpvsgrDEiGeLarafNaMldrLr 52 
                  ++lr++ +L++++r   + G d+++++p  g DEiG+L   +N+Ml +L+
  EFC36184.1 423 SSVLRRILKLSKSVRDFYEsGnDFNKTIPQLGHDEIGTLSSKINQMLASLK 473
                 689***************6556*************************9996 PP

>> CHASE4  CHASE4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.1   1.4e-08   2.3e-05       1     135 [.      83     271 ..      83     273 .. 0.79

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 1.4e-08
      CHASE4   1 alqaeldqlerllkdwavWDdtyafvqdrdpd....yiesnlgdetletlgldlvlfldadgklvy........................dqengq... 68 
                 al ++l+ l++++ ++   D+t ++v++ +++    y+ + ++ + l+  +++++lf+  +g+++                                  
  EFC36184.1  83 ALFDDLKLLSDRTFEYGSFDSTTELVNGASQEtidqYMSDYMNCDYLNRVNVNMALFYYLNGTMLRgihcfkgvsieglpseltnldqetV----Dgqs 177
                 57789999********************8888688899999999*********************65667788888888888886644330....2555 PP

      CHASE4  69 ............................ekllseaeee...s.grsgllkldggpalvaaapI..ltsegegpsrGtlvfgryldeallsrlseltlld 133
                                             +    e +++   +  +s + ++  +++lv a+pI       + +s G+l f++y + ++l ++se+t+++
  EFC36184.1 178 neyrkffinnlenpstrhiglmipskklS----ELATSetsQqAVSNYSSILSNVLLVNAMPIqgY---DSLESFGMLTFAKYNTYDYLLDISERTQFC 269
                 55666776666666677777777755532....222223322599******************433...3589************************99 PP

      CHASE4 134 le 135
                 ++
  EFC36184.1 270 VT 271
                 87 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       9.2   1.5e+04      35      74 ..     282     319 ..     267     328 .. 0.71
   2 ?   -1.1   0.6       1.4   2.2e+03      30      77 ..     439     490 ..     431     561 .. 0.51
   3 ?   16.0   1.6   6.9e-06     0.011       2     112 ..     641     756 ..     640     758 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 9.2
                 HHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHH CS
         RGS  35 eefkkakeqeelkkkakeIyneylapsspkelnidkklre 74 
                 + fk + +++++++  ++I +e++ p   ++ n+ ++ ++
  EFC36184.1 282 SAFKLS-TSNAISDSLDAITSEWI-PTNISSTNVYSDWTN 319
                 445555.88888888888888888.666666666666655 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.4
                 HHHHHHHHHTS........................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHH CS
         RGS  30 Fwlaveefkka........................keqeelkkkakeIyneylapsspkelnidkklreele 77 
                 F++  ++f+k+                        k                     +++l  d ++++e+ 
  EFC36184.1 439 FYESGNDFNKTipqlghdeigtlsskinqmlaslkK--------------------NQEKLVSDMDTMQEML 490
                 666666666665555543333222222222222221....................1122222222222222 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 6.9e-06
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke......qpsrklfeeaq 94 
                 ++++++d +++s F + +   +++++++  ++ e++k +++ +++ k  k+I++ yl  ++++  n+++  r++++++ +++        + ++fe+++
  EFC36184.1 641 FNRIISDDYLKSRFLQLCPIPNASKYMAMIEKLETYKLTNKPQQRAKLHKKIVESYL-IDQNNISNLSDFPRSSIQTFNTEAkkaissLAHFDVFEKIE 738
                 899******************************************************.555555577777777777776666666887778899***** PP

                 HHHHHHHHHHHHHHHHTS CS
         RGS  95 eevfellekdsypkFlks 112
                   v  +l + +y+ F+++
  EFC36184.1 739 VIVKLILINLAYTSFMEN 756
                 **************9986 PP

>> AI-2E_transport  AI-2E family transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.2      0.12     2e+02     131     149 ..      37      55 ..       5      83 .. 0.56
   2 ?   12.7   0.4   3.1e-05     0.051      46     132 ..     395     479 ..     392     496 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.12
  AI-2E_transport 131 nsllsllasllglilslvl 149
                      ++++ l+   + l+  ++ 
       EFC36184.1  37 KTISVLVVMFILLVCFCLA 55 
                      2222222222222222222 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 3.1e-05
  AI-2E_transport  46 gvkrvlavllvlllllvllvllvlllvpl.liaqltqlvkslpayidslqnilnelpslleelenliqalkqslskilsnilssilns 132
                      g+  +l+v +v+++++++l   v++++ + ++  + +l ks+ ++++s +++ +++p+l   +   i +l ++++++l+++ ++  + 
       EFC36184.1 395 GMASFLVVWFVMTFFVLVLSAGVVIFIESsVLRRILKLSKSVRDFYESGNDFNKTIPQLGHDE---IGTLSSKINQMLASLKKNQEKL 479
                      667889999999999999988888888651678999**********************99999...8999999999999998876555 PP

>> TMEM132D_C  Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00016      0.26      23      48 ..      34      58 ..      14      81 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00016
  TMEM132D_C 23 qasraltdLEiGmYaLlgvfClAilv 48
                 + ++++ L + m+ Ll  fClAil 
  EFC36184.1 34 LRLKTISVL-VVMFILLVCFCLAILL 58
                444445444.78************85 PP

>> Tetraspanin  Tetraspanin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.3    0.0043         7      76     128 ..      40     128 ..      33     163 .. 0.71
   2 ?   -3.1   0.0       3.2   5.1e+03     112     138 ..     301     330 ..     245     364 .. 0.61
   3 ?    8.2   0.2    0.0012       1.9      81     143 ..     398     490 ..     389     548 .. 0.72

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0043
                  XXXXXXXXXXXXXXXXXXXXXXXXXX--HHH.............................................HHHHHHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....................................xxxxxxxxxxxxxxxxxxxxxx RF
  Tetraspanin  76 kcllltfsllllvlfllelaagilgfvfsdk.....................................argkvseiinnaievkyrddld 128
                   +l ++f+ll++++++++l+  +l+f++ ++                                      +g  +e i++++ ++y ++  
   EFC36184.1  40 SVLVVMFILLVCFCLAILLTSFFLIFHNVERvestqssrrvsralfddlkllsdrtfeygsfdsttelVNGASQETIDQYM-SDYMNCDY 128
                  467777777777777777777777777777777777777777777777777777777777777766665555555566666.55555555 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.2
                  ...HHHHHHHH..HHHHHHHHHH.THHHHH CS
                  xxxxxxxxxxx..xxxxxxxxxx.xxxxxx RF
  Tetraspanin 112 seiinnaievk..yrddldlkkc.qnllds 138
                  se+i ++i+++  y d+ +      + +d 
   EFC36184.1 301 SEWIPTNISSTnvYSDWTNDAASlVKVIDI 330
                  444444443221133333333333333333 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0012
                  XXXXXXXXX..XXXXXXXXXXXX--HHH.......................................HHHHHHHHHHHHHHHHHHTHHHHHHHHHH CS
                  xxxxxxxxx..xxxxxxxxxxxxxxxxx...............................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Tetraspanin  81 tfsllllvl..fllelaagilgfvfsdk...............................argkvseiinnaievkyrddldlkkcqnlldslqkkl 143
                  +f+++ +v+  f+l l+ag+++f+ s+                                + g++s++in+ + +  +++++l    +++d++q++l
   EFC36184.1 398 SFLVVWFVMtfFVLVLSAGVVIFIESSVlrrilklsksvrdfyesgndfnktipqlghdEIGTLSSKINQMLASLKKNQEKL---VSDMDTMQEML 490
                  5554444433399999999999999999666666666666666666666666666666655555666666653333333333...58888888876 PP

>> Snapin_Pallidin  Snapin/Pallidin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.5    0.0011       1.7      18      53 ..     465     501 ..     459     525 .. 0.84
   2 ?    4.7   1.1     0.024        40      29      54 ..     618     644 ..     612     651 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0011
  Snapin_Pallidin  18 ldeklkelrqsQeeLleqldrlnekLkeleeaqe.ae 53 
                      +++ l++l+++Qe+L +++d+++e L++++  ++ + 
       EFC36184.1 465 INQMLASLKKNQEKLVSDMDTMQEMLERTSIQEQsNR 501
                      6778999********************9998877544 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.024
  Snapin_Pallidin  29 QeeLleqldrlnekLkeleeaqe.aev 54 
                       +eL+++l+ + +kL+e++++ + + +
       EFC36184.1 618 ENELQQSLQDQETKLEEMKKILDfNRI 644
                      689*****************9996655 PP

>> HemY_N  HemY protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.5    0.0059       9.6      16      63 ..      40      84 ..      31      89 .. 0.47
   2 ?    4.6   0.5     0.023        38      17      51 ..     406     440 ..     395     445 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0059
      HemY_N 16 lvvavlllvllfvllylllrllrlllrlparvrrwrrrrrerkareal 63
                 v++v++++l+ + l +ll     ++ + ++v r  + +  r+  +al
  EFC36184.1 40 SVLVVMFILLVCFCLAILLT---SFFLIFHNVERVESTQSSRRVSRAL 84
                22333333333333333333...3344445556665556666555554 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.023
      HemY_N  17 vvavlllvllfvllylllrllrlllrlparvrrwr 51 
                 +++++l++ + v++++  ++lr++l+l+++vr + 
  EFC36184.1 406 MTFFVLVLSAGVVIFIESSVLRRILKLSKSVRDFY 440
                 455666666666777778899*******9999875 PP

>> DHHC  DHHC palmitoyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   1.5   0.00084       1.4      82     132 ..      22      75 ..       8      77 .. 0.62
   2 ?    1.4   0.3       0.2   3.2e+02      94     115 ..     398     419 ..     356     436 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00084
        DHHC  82 kseflavtllkk...llsilllvlsllfllllgllllfhlylilrnlTtieamk 132
                 ++++++++++++    +  +l+v+ +l++++ +++ll++++li++n+ + e ++
  EFC36184.1  22 QQQENIFKKHSSlrlKTISVLVVMFILLVCFCLAILLTSFFLIFHNVERVESTQ 75 
                 333333333333444455666666777888888888899999999998888765 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.2
        DHHC  94 llsilllvlsllfllllgllll 115
                  + ++++v+ +++l+l + +++
  EFC36184.1 398 SFLVVWFVMTFFVLVLSAGVVI 419
                 2334444444444444443333 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.4   0.00036      0.58      43      92 ..      21      68 ..       2      82 .. 0.56
   2 ?    1.3   0.1      0.26   4.3e+02      56      79 ..     390     413 ..     350     429 .. 0.60
   3 ?   -3.1   0.5       5.9   9.6e+03      44      75 ..     481     512 ..     463     514 .. 0.44

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00036
       Orf78 43 aaeknditekesnaaekaqalnillisllavvcvlvllyviyYfvilrer 92
                ++++++i +k+s+ + k+ +  ++++ ll+++c+ +ll   ++f+i  + 
  EFC36184.1 21 TQQQENIFKKHSSLRLKTISVLVVMFILLVCFCLAILL--TSFFLIFHNV 68
                33444444444444555556677777777777777777..3455554432 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.26
       Orf78  56 aaekaqalnillisllavvcvlvl 79 
                 ++ + ++ + l++ +++ + vlvl
  EFC36184.1 390 SSFQVGMASFLVVWFVMTFFVLVL 413
                 444555556666666666666665 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 5.9
       Orf78  44 aeknditekesnaaekaqalnillisllavvc 75 
                 ++   ++e+ ++++ ++q+  +++ s+  +++
  EFC36184.1 481 SDMDTMQEMLERTSIQEQSNRCIMNSINEFIA 512
                 22222222222234455555555555555555 PP

>> DUF724  Protein of unknown function (DUF724)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.4   0.00013      0.22      87     184 ..     458     556 ..     428     559 .. 0.90
   2 ?   -2.4   0.1       2.3   3.7e+03     171     184 ..     622     635 ..     611     656 .. 0.58
   3 ?   -0.0   0.1      0.41   6.7e+02      85     117 ..     731     763 ..     708     788 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00013
      DUF724  87 VkalqsrlnkLl.slkdeqtklleerkklekkieeeesekrkleeeidelekkilelerqlallkekkeaadkeiarlkseaekleeeledveqeFeav 184
                 + +l s++n++l slk++q+kl + +  +++ +e  + ++++    ++ +++ i+ +e+   l+ + ++  d+++++++ ++++++  ++ + + F+++
  EFC36184.1 458 IGTLSSKINQMLaSLKKNQEKLVSDMDTMQEMLERTSIQEQSNRCIMNSINEFIAIVEKSTGLIVNTNSYFDNKLVDSNENQQQVNYLHDTIDKFFKET 556
                 778999**988757********************************************************************99999888888888776 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.3
      DUF724 171 eeeledveqeFeav 184
                 +++l+d e++ e++
  EFC36184.1 622 QQSLQDQETKLEEM 635
                 33333333222222 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.41
      DUF724  85 FdVkalqsrlnkLlslkdeqtklleerkklekk 117
                 FdV    + + kL+ ++  +t+ +e++k + ++
  EFC36184.1 731 FDVFEKIEVIVKLILINLAYTSFMENIKTILSE 763
                 888888899999999999999999888875332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2091  (0.116627); expected 358.6 (0.02)
Passed bias filter:                      695  (0.038764); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.84u 0.31s 00:00:01.14 Elapsed: 00:00:00.54
# Mc/sec: 4537.85
//
Query:       EFC36185.1  [L=474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-10   41.3   0.0    0.00017   21.2   0.0    3.5  3  Ras       Ras family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.0   0.00022       3.9       2      27 ..      72      97 ..      71     117 .. 0.87
   2 !    8.7   0.0     7e-05       1.3      70     102 ..     196     228 ..     188     234 .. 0.88
   3 !   21.2   0.0   9.4e-09   0.00017     104     158 ..     266     322 ..     256     326 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00022
                EEEEESTTSSHHHHHHHHHHSSCSSS CS
         Ras  2 lvlvGdsavGKtslllrfvkdkFkee 27
                + ++G ++vGK sl+   ++++++ +
  EFC36185.1 72 ICVLGTRGVGKKSLVSYMINGYYNPS 97
                679*************9999999865 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 7e-05
                 TTESEEEEEEETTBHHHHHTHHHHHHHHHHHST CS
         Ras  70 rdaegillvyditsresfenvkkwveeikrvae 102
                   a+ +++vyd+t+  sfe++  ++e+++++++
  EFC36185.1 196 ARAHLVIMVYDVTELPSFESLVLYHEQLSKITS 228
                 678999********************9998876 PP

  == domain 3  score: 21.2 bits;  conditional E-value: 9.4e-09
                 TSEEEEEEETTTGGGG-SS-HHHHHHHHHHHT..SEEEEEBTTTTCTHHHHHHHHHH CS
         Ras 104 nvpivLvGnKvDleekravsteegeelakelg..lkfletSAktnenveeafeellr 158
                 + +i+ vG K+Dle++r+vs+++  +  + +g  +kf+e+S  t env + fe++ +
  EFC36185.1 266 QRKIMAVGVKTDLEDDRTVSESHILSHRNVIGsdIKFYECSSVTGENVLTFFEDVKE 322
                 568999*****************99999888878******************99865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       957  (0.0533772); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2706.24
//
Query:       EFC36186.1  [L=518]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.6e-35  122.7   0.2    7.1e-34  117.3   0.0    2.3  2  LBP_BPI_CETP_C  LBP / BPI / CETP family, C-terminal domain
    3.3e-10   39.8   1.1      1e-09   38.2   0.2    2.1  2  LBP_BPI_CETP    LBP / BPI / CETP family, N-terminal domain


Domain annotation for each model (and alignments):
>> LBP_BPI_CETP_C  LBP / BPI / CETP family, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.2   0.0    0.0058        52     179     213 ..      57      90 ..      33     101 .. 0.89
   2 !  117.3   0.0   7.9e-38   7.1e-34      23     238 .]     291     506 ..     270     506 .. 0.94

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.0058
                     --GGGGHHHHHHHHHHHCHHHHHHHHHH-EE---- CS
  LBP_BPI_CETP_C 179 fsveslqalLnymitelleplvneklqkgfplplp 213
                     +sv++ q +Ln ++++ l p +++++   +++p+ 
      EFC36186.1  57 ISVNTQQRALN-YMSNQLTPFIQKQITSTIAIPDV 90 
                     689999****9.6677789*************986 PP

  == domain 2  score: 117.3 bits;  conditional E-value: 7.9e-38
                     -----------SSSEEEEEEHHHHHHHHHHHHHTT-SEEEEEGGGS-TT-S--SBHHHHCTTSTTHHHHSTT-BEEEEEEESS--EEEEETT.EE CS
  LBP_BPI_CETP_C  23 lppvealpeesdrMvylaiSdylfnslllvayragfLkltltddmlpassdlrlttkcfgeflpelaeqfPnrqlelevsalkaPlislspk.gl 116
                     ++p ++   + d+M ++++Sdy+ n++ ++  +ag  + +lt   +p s + + +t++++ flp+l  ++P  ++++ +++ ++P is+sp  g+
      EFC36186.1 291 PTPSMPNSLGADKMAEIFVSDYTLNTAGFAFNEAGLFNYLLTQHIFPSSFQWLFNTTNLQYFLPQLYAKYPGLEMQIDFTTASPPTISISPAnGA 385
                     4555777789*********************************************************************************9899 PP

                     EEE-EEEEEEEEE-TTS-EEEEEEEEEE--EEEEEEEETTEEEEEEEE---EEEEEEETT----GGGGHHHHHHHHHHHCHHHHHHHHHH-EE-- CS
  LBP_BPI_CETP_C 117 tvslslsvnvfvvlPnqqkeqvltldvdtnasvtlsingkkvvgslkleklqlklkeskvgefsveslqalLnymitelleplvneklqkgfplp 211
                      v+l ++  + vv P ++   ++ l+ ++++++++si  ++++g l+ +  ++ l  s++g+++v++++ ++  +    ++p  n + ++gfplp
      EFC36186.1 386 EVNLIAQAIFQVVQPTGP-VNAFALNFNAVMDLEASIVASNITGTLTYKSSNVTLAYSNIGPLDVQLVSTIVDLIFEYGVVPIGNTLAKRGFPLP 479
                     ***************996.468999999*********************************************999******************* PP

                     --TTEEEEEEEEEEETTEEEEEEEEEE CS
  LBP_BPI_CETP_C 212 lpkglqlkdlklqihdrfLllgadvkl 238
                      ++gl l++++++  +rf+ +  d+ +
      EFC36186.1 480 SLQGLTLVNPVISYQNRFIAIRSDFTY 506
                     ************************987 PP

>> LBP_BPI_CETP  LBP / BPI / CETP family, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2   0.2   1.1e-13     1e-09       1     162 [.      65     238 ..      65     239 .. 0.82
   2 ?   -0.7   0.0      0.11   9.5e+02      36     100 ..     357     423 ..     340     460 .. 0.64

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 1.1e-13
                   HHHHHCHHHHHHHHHHHH.TS-CCCEEEEEEETTTECEEEEEEEEEEEEEEEEEEEEEEETTTEEEEEEEEEEEEEEEEEEEC.........ECCEE CS
  LBP_BPI_CETP   1 gLdyakqeglkvlqkele.klqlpdilgeekikllgkvkynisnlkIsnlqlpslslklspggglllliiplslkisgklpll.........gsfle 87 
                   +L+y +++++  +qk++  ++ +pd+++ ++++ +g++   is++  sn+ +   s+ + p       i++++++++ ++ ++         ++  +
    EFC36186.1  65 ALNYMSNQLTPFIQKQITsTIAIPDVTTRVDTP-IGHLTATISQITLSNFDISIPSIVVGPTAL-QITISNAQASLHCNWHYRedswphisdSGSAD 159
                   6899999999999998752699*********66.8************************99988.88999*************66655555445555 PP

                   EEEEEEEEEEEEEEEETTSEEEEEEEEEEEEEEEEEEEETTC....GHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  LBP_BPI_CETP  88 lavgvsitaelalerdeqGrprlvlseCsssigsislsllgg....lgslldlltnllektlkkvlesqlCpviqsvLs 162
                    +v ++it++  +   ++ +  +vl++ +  + s +l+l gg     +++l+++++ +e++ ++ ++ q+   i+ vLs
    EFC36186.1 160 ASVAIDITLTAQIVIIDESHFNVVLGNFNAKFTSFNLKLHGGaswlYNVFLNNFRDSIEQSAQNAINTQVAGAINTVLS 238
                   5999999999999998999***********************5555555555666666666666666667777788877 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.11
                   CEEEEEEEEEEEEEEEEEEEEEEETTTEE.EEEEEEEEEEEEE.EEEECECCEEEEEEEEEEEEEEE CS
  LBP_BPI_CETP  36 kvkynisnlkIsnlqlpslslklspgggl.llliiplslkisg.klpllgsflelavgvsitaelal 100
                   + ky  ++++I+  +    ++  sp +g  + li+++ +++     p+++  l++ + ++++a++ +
    EFC36186.1 357 YAKYPGLEMQIDFTTASPPTISISPANGAeVNLIAQAIFQVVQpTGPVNAFALNFNAVMDLEASIVA 423
                   5567777778877777777777777777667777777666655466666555555555555555543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (518 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       652  (0.0363657); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.38s 00:00:01.06 Elapsed: 00:00:00.58
# Mc/sec: 2696.40
//
Query:       EFC36187.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0074   15.8   0.7      0.011   15.3   0.7    1.4  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.7   5.9e-07     0.011     140     233 .]     136     226 ..      22     226 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 5.9e-07
                    HHHTTSEEEEEEE-SSSTSGGGBSCGHHHHHHCTTTHH................SSCESCETTTTTTTTTTTEB-BEEEEEECHHHCCEEEEEEEC CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 140 nadrgapvivaGDfNarpsdddsrvlrtrglalapapv................glyllgggptptyvtraggsrlDrilaspalalfrsgvlppp 219
                     ++++ +v+++GD N     d          +l+ + +                 +  + ++p++   + + +++lD+++ s+           ++
     EFC36187.1 136 IDFENVRVVICGDYNI----D----------SLHSNDSyaylknsmsslglknvFGDDTSRHPVTYPIPTFNNWCLDHVFISN----------NCK 207
                    3455666888******....2..........22222213333444555778899****************************7..........455 PP

                    CHHEEC.....TSSCSSSB CS
                    xxxxxx.....xxxxxxxx RF
  Exo_endo_phos 220 lalvrr.....ealtlSDH 233
                    ++  +      +++ +SDH
     EFC36187.1 208 HSFDIIrwkneDGIEVSDH 226
                    5444447777778888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       826  (0.0460706); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.33s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1401.35
//
Query:       EFC36188.1  [L=316]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.6e-47  162.1   0.0    4.3e-46  157.5   0.0    2.0  1  Aldo_ket_red  Aldo/keto reductase family


Domain annotation for each model (and alignments):
>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  157.5   0.0   2.4e-50   4.3e-46       4     292 ..      24     295 ..      21     297 .. 0.93

  Alignments for each domain:
  == domain 1  score: 157.5 bits;  conditional E-value: 2.4e-50
                   EE-SSS-ST.TS-HHHHHHHHHHHHHTT--EEE--TT-TTTHHHHHHHHHHHH.....-TTTGGG-EEEEEE--SSSTTSSSS-HHHHHHHHHHHHH CS
  Aldo_ket_red   4 lGtwqlgskeeiskeealellrraleaGinffDtAevYgkgqseellGealkk.....srkkreeviiatKvdlrdaeiksglskeniresleeslk 95 
                   lGtw        ++ e+ ++++ ale G++++D+A +Y   ++e+++Ge + +     ++++r +v +++K+      ++  ++ke++r+++ ++l+
    EFC36188.1  24 LGTWLS------APGEVSRAVEFALEQGYRHIDCAAIY---RNEQEIGETFDRlfnteKKFNRSDVYVVSKL------WNTFHKKEHVRKACLQTLS 105
                   555532......46789999******************...********9999999999*************......******************* PP

                   HHT-S-EEEEEE-S--TTS-..........................HHHHHHHHHHHHHTTSEEEEEEES--HHHHHHHHHTTT--EEEEE-B-BTT CS
  Aldo_ket_red  96 rLgtdyvDllllHrpdpslp.........................sieevldaleelvkeGkiraiGvSnfsveqlekakkkkkvkivavqveynll 167
                    L++dy+D++l+H+p+   +                          + e+++ +e+lv+ G++++iG+Snf+++ +  +++ + +k++a+qve++++
    EFC36188.1 106 DLKLDYLDMYLIHWPFNFKYvgddikkdenvfpkdengkiameavPLRETWEEMEKLVDDGLVKSIGISNFPIALVYDLLTYARIKPAANQVECHPY 202
                   ***************9888889*************************************************************************** PP

                   -HHHHTTHHHHHHHTT-EEEEBSTTGGGTTGTTTSS---SSSCCC-------TS-HHHHHHHHHHHHHHHHTT--HHHHHHHHHTTSTT-SEEEE-- CS
  Aldo_ket_red 168 releeegllelckkkgvpliaysplggGlltgkyqseedkedkeprkdlkrdertsknldaaeelselakehgvslaqlalryalsqpavgivipga 264
                     l++++l +++ +  ++l+aysplg+       ++++++                     ++++++la++ g+++aq+ l++ +  +++ ivip++
    EFC36188.1 203 --LNQRKLKQALGD--IALVAYSPLGH------FNESSPV--------------------NNQTVKSLAEKLGKTPAQILLKWST--QRGCIVIPKS 267
                   ..*******99998..**********3......2333333....................489**********************..9********* PP

                   SSHHHHHHHHGGGG----HHHHHHHHHH CS
  Aldo_ket_red 265 snieqlednldalelklseeevaeldel 292
                   ++ e++ +n + ++++ls+e+++ l+ l
    EFC36188.1 268 TKEERIIENSKIFDFELSSEDMESLEGL 295
                   ************************9977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.34s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1928.07
//
Query:       EFC36189.1  [L=1316]
Description: histone deacetylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.7e-90  301.9   0.0      9e-90  301.3   0.0    1.3  1  Hist_deacetyl  Histone deacetylase domain
    7.9e-38  130.1  64.8    1.3e-12   47.5  10.9    5.0  6  NosD           Periplasmic copper-binding protein (NosD)
    7.7e-37  126.6  63.8    2.9e-17   62.9  12.7    5.8  5  Beta_helix     Right handed beta helix region
    1.2e-19   70.4   0.6    2.4e-09   37.4   0.0    3.3  3  BRCT           BRCA1 C Terminus (BRCT) domain
    1.6e-18   66.4   0.3    5.2e-13   48.7   0.1    2.7  2  PTCB-BRCT      twin BRCT domain
      4e-10   40.0   0.0    0.00032   21.0   0.0    3.4  3  BRCT_2         BRCT domain, a BRCA1 C-terminus domain
    1.1e-05   25.7   0.3      0.035   14.4   0.0    3.3  3  LIG3_BRCT      DNA ligase 3 BRCT domain
    3.9e-05   23.5   0.0    0.00023   21.0   0.0    2.3  2  RTT107_BRCT_5  Regulator of Ty1 transposition protein 107 BRC


Domain annotation for each model (and alignments):
>> Hist_deacetyl  Histone deacetylase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  301.3   0.0     4e-93     9e-90       2     305 ..     384     691 ..     383     693 .. 0.94

  Alignments for each domain:
  == domain 1  score: 301.3 bits;  conditional E-value: 4e-93
                    CCGTHHHHHHHHHHHHT.THHHHCCE.EE-----HHHHTTTS-HHHHHHHHCHHHHCHHT.TTHCCHHHCCTSTSSSSSTHCTTTCCHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl   2 penpkRlsaileslaesvglldelelliqpseatkeellkvHskeYlelleslsnelkkkeeakekeleeiasklldddtpvspktlkaallavga 97 
                    pe+p R+s+i++ ++e+ +llde+e +++++e+t++el+ vH+++Y+++  + + + +++ ++++  l+ i ++  ++d+ +++ +lkaa+la+g+
     EFC36189.1 384 PETPVRISHIWNMIQEH-NLLDECE-IMKSREVTQQELALVHTEKYIDDFFEFKGQFNPTTSNHNL-LRGIVQD-NEHDIQINQFSLKAARLAAGG 475
                    89**************8.9999888.5********************************9855544.5555555.6999***************** PP

                    HHHHHHHHHTTSSSEEEETTSS--TT-BTTB-BTTBSS-HHHHHHHHHHHCC-SS-EEEEE-SSS--HHHHHHCTT-TTEEEEEEEE-CCTSTTSS CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl  98 vleavdavlsgsvkaafvlvrPpgHHakaseasGFClvNnvaiaikylqakhelkrvailDvDvHhGnGteeafysdpdvltlSiHryegifyPgt 193
                    v+++ ++vl+g++++++++vrPpgHHa+ ++++GFC++Nn+a+a++++q+  ++ rvai+D+D+HhGnGt+e+f++dp++l++SiHr+e++++Pgt
     EFC36189.1 476 VIKLTEKVLNGELENGMAIVRPPGHHAQTEDPMGFCFFNNAAVAARVAQQFKSVGRVAIIDFDIHHGNGTQEIFEDDPSILYVSIHRFEQNYFPGT 571
                    **************************************************7789****************************************** PP

                    --TT---SGGGTTSEEEEEE-TT.........-BHHHHHHHHHHCHHHHHCCH--SEEEEEE-STTBTTS.TT-S-BB-HHHHHHHHHHHCCCHGS CS
                    xxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 194 galedlgegkgkgfnlnvpleeg.........tgdeeylkvfeeilrpvleefkPdlilvsaGfDalkgd.plgelnlsvegykeltkklaeladk 279
                    g+le++g gkg+g++ln+pl+++         +gd++y+++f+++++pv  ef Pdl++vsaGfDa+kgd   ++++l+++gy++++ +l++la  
     EFC36189.1 572 GSLEEVGIGKGEGYTLNIPLPPKdykipstatFGDSDYIAIFRQLIIPVCTEFAPDLVIVSAGFDAAKGDiLGRRMSLTPSGYEHIIGMLKQLAG- 666
                    **********************8889999999**************************************444568******************8. PP

                    -G.EEEEE-S---HHHHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 280 vkkvvllleGGYnlealaravtavls 305
                     +k+vl leGGY+++ +a+++ta l+
     EFC36189.1 667 -GKIVLALEGGYKTDVTASCATASLR 691
                    .5******************998776 PP

>> NosD  Periplasmic copper-binding protein (NosD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.4   5.0         8   1.8e+04      44     120 ..     255     337 ..     215     357 .. 0.54
   2 ?    0.1   2.1      0.18   4.1e+02     114     178 ..     849     913 ..     774     923 .. 0.66
   3 !   43.0   9.4   1.4e-14   3.1e-11      15     173 ..     930    1085 ..     916    1087 .. 0.82
   4 !   46.1   9.6   1.6e-15   3.5e-12      43     158 ..    1045    1162 ..    1044    1171 .. 0.89
   5 !   39.9  11.0   1.3e-13   2.9e-10      52     168 ..    1077    1197 ..    1071    1200 .. 0.57
   6 !   47.5  10.9   5.7e-16   1.3e-12      31     150 ..    1173    1292 ..    1165    1314 .. 0.92

  Alignments for each domain:
  == domain 1  score: -5.4 bits;  conditional E-value: 8
        NosD  44 dnssnntitgntienl......ryGihlensesntiedntlssnesGialmsssnntlenNtisnnenyGillsdssnntisn 120
                 +n ++n + +   +++      r  i  +ns+   +e+n + +ne+  ++++ s    ++Nt+   e++  l++ +++ +++n
  EFC36189.1 255 SNTKKNIFVNLDSSDQlktycdRVVIGKNNSKVLLVENNPTAQNEDEKIVDMDSFLNGRQNTLEFVEKNKHLITIIDSDKLNN 337
                 33333333333222223332222222223333367777777777765566666656666777666665333333333334444 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.18
        NosD 114 snntisnNtis.nnnkGiflens.ssntitgNriesnqkiGilllsssegntiynNyFinnsenvky 178
                 sn +i+ Nt +  +   i  e+s ++  i    i+   + G   + ++ +n i++N+F++ ++++k 
  EFC36189.1 849 SNEKIRINTKMnHKLIHIIGEESeKQAHILYPIITLG-EAGSI-MLEAGSNIIFENIFFKATKEAKS 913
                 3444555555433344444444434444555555555.66666.55566899999999988888776 PP

  == domain 3  score: 43.0 bits;  conditional E-value: 1.4e-14
        NosD   15 rgngiqlensegseisnneisnsrdgilldnssnntitgntienlryGihlenses.ntiedntlssnesGialmsssnntlenNtisnnenyGill 110 
                  +g  i+l+   ++ei+n + s+ +    ++ +s+ +i ++ ++++ +Gi  e  +s   i+++++ +ne++i+ ++s+   ++nN i+++++++ l+
  EFC36189.1  930 QGLHIRLDDGAECEIRNCKFSRFS--TIATRNSSLKIVNSEFRES-EGIACEIRSSqAFIHNSKFVMNENAIVAEKSQ-LKITNNLITGSKKKSLLM 1022
                  444567777777777777766544..3468888899999888777.9999997666599******************9.9**************999 PP

        NosD  111 sdssnntisnNtis.nnnkGiflens.ssntitgNriesnqkiGilllsssegntiynNyFinns 173 
                   +s+++ +++N+i  n+++Gi+l ++ ++ +it+N i +++  Gi++ ++++  +++n +F +n+
  EFC36189.1 1023 IQSTGT-VQENEIIrNESSGIQLFKEcKDVKITKNVIMGQKAAGIVVNAQCKATLMHNQIF-DNT 1085
                  999985.******99********99989******************999998855555555.665 PP

  == domain 4  score: 46.1 bits;  conditional E-value: 1.6e-15
        NosD   43 ldnssnntitgntienl.ryGihlensesntiedntlssne.sGialmsssnntlenNtisnnenyGillsdssnntisnNtis.nnnkGiflenss 136 
                  ++++++++it+n+i  + ++Gi+++ + + t+  n++++n+ +Gi +++++n  +  N+i +  + Gil+ + s  t+++N+i  n ++G+ l+n s
  EFC36189.1 1045 FKECKDVKITKNVIMGQkAAGIVVNAQCKATLMHNQIFDNTmAGIEVSNECNIDIIENEIYKGGICGILIATKSRGTVEKNRIYeNAYAGLELRN-S 1140
                  678999******9988889**********************9*********996668888888899*****************99**********.6 PP

        NosD  137 sntitgNriesnqkiGilllss 158 
                  + ti++N+i+sn++ G+ +  +
  EFC36189.1 1141 NPTIRNNQIYSNRQSGVSIKGK 1162
                  9****************94433 PP

  == domain 5  score: 39.9 bits;  conditional E-value: 1.3e-13
        NosD   52 tgntienl.ryGihlensesntiedntlssne.sGialmsssnntlenNtisnnenyGillsdssnntisnNtis.nnnkGiflens..ssntit.g 142 
                   +n+i ++  +Gi ++n  ++ i +n++++ + +Gi++  +s+ t+e+N+i +n ++G  l++s+  ti+nN+i  n ++G++++++  +++ i  g
  EFC36189.1 1077 MHNQIFDNtMAGIEVSNECNIDIIENEIYKGGiCGILIATKSRGTVEKNRIYENAYAGLELRNSNP-TIRNNQIYsNRQSGVSIKGKdiDNTLIFqG 1172
                  344333333666666666666666666666666666666666666666666666666666666665.366666655666666666665444444346 PP

        NosD  143 NriesnqkiGilllsssegntiynNy 168 
                  N+i sn   Gi  + ++ + +i++N 
  EFC36189.1 1173 NEILSNVYSGIE-IRQGATPSIVGNR 1197
                  666666666666.6666666666664 PP

  == domain 6  score: 47.5 bits;  conditional E-value: 5.7e-16
        NosD   31 nneisnsrdgilldnssnntitgntienl.ryGihlensesntiedntlssnesGialmsssnntlenNtisnnenyGillsdssnntisnNtis.n 125 
                  n+ +sn+++gi + +  + +i gn+i  + ++Gi ++++++ +ie+n++++n++Gi++++    t++ N+i+nn+n+G+ +++ +  +i +N+is n
  EFC36189.1 1173 NEILSNVYSGIEIRQGATPSIVGNRIFGCaKQGIIVVEQSNPIIEKNEITENSDGIIVQKAY-ATIKENKIINNSNMGVKVRQFE-ADIIDNEISaN 1267
                  4567999**********************9*******************************9.9***************999988.5699*****9* PP

        NosD  126 nnkGiflensssntitgNriesnqk 150 
                   + +i+ ++ ++ ti++N+i+++++
  EFC36189.1 1268 GSFAIYGDECDRLTISKNKISAHKS 1292
                  *********************9854 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   2.2       2.7     6e+03      76     133 ..     256     316 ..     229     346 .. 0.46
   2 !   22.0   6.6   5.2e-08   0.00012      24     144 ..     888    1022 ..     810    1027 .. 0.83
   3 !   62.9  12.7   1.3e-20   2.9e-17       6     158 .]     957    1104 ..     953    1104 .. 0.94
   4 !   55.4  13.6   2.7e-18     6e-15      39     149 ..    1079    1190 ..    1075    1194 .. 0.93
   5 !   28.2   6.4   6.4e-10   1.4e-06       2      80 ..    1227    1306 ..    1226    1316 .] 0.84

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.7
                 --S--EEES-EEES-.....SS-SEE-TT-S--EEES-EEESTT--SEE---TT---EEES-E CS
  Beta_helix  76 gasnnlienneitdn.....ggsGiylnyssnntienNiidnnagsGividdsssnvtvtnNt 133
                 ++++n++ n + +d      +++ i  n+s+ + +enN    n+   iv +ds   ++ ++Nt
  EFC36189.1 256 NTKKNIFVNLDSSDQlktycDRVVIGKNNSKVLLVENNPTAQNEDEKIVDMDSF--LNGRQNT 316
                 444444444444444222211112222222223344444444444444444444..2223333 PP

  == domain 2  score: 22.0 bits;  conditional E-value: 5.2e-08
                  -SEEE-SSS-.EEES.............-EEES...........-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE CS
  Beta_helix   24 yGiylrgssnvvien.............neian...........nsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdnggsGiy 96  
                    i+l+ +sn+++en                             ++g  i++  ++++ i+n+++s++    ia++++s   i n+e+++ +  Gi 
  EFC36189.1  888 GSIMLEAGSNIIFENiffkatkeaksadV---VvtpqqnggnpkSQGLHIRLDDGAECEIRNCKFSRFS--TIATRNSS-LKIVNSEFRESE--GIA 976 
                  56788888888888655555554444442...04446777778888999999999***********888..67776666.9999*****996..677 PP

                  -T.T-S--EEES-EEESTT--SEE---TT---EEES-EEES-SSEEEE- CS
  Beta_helix   97 ln.yssnntienNiidnnagsGividdsssnvtvtnNtitnnkgaGiav 144 
                  ++  ss+  i+n+ +  n+ ++iv + s+  +++tnN it++k++++  
  EFC36189.1  977 CEiRSSQAFIHNSKFVMNE-NAIVAEKSQ--LKITNNLITGSKKKSLLM 1022
                  77779**************.*********..999******999887754 PP

  == domain 3  score: 62.9 bits;  conditional E-value: 1.3e-20
                  -SS-E.EEESEEEES-SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S CS
  Beta_helix    6 ngssnvtiknntisnsggyGiylrgssnvvienneiannsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdnggsGiyln.yss 101 
                  +++s+++i n+++++s g +  +r+s+   i n+++   +++ i  ++ s  +i+nn i++++     l+  s  +++ nei++n++sGi+l+  ++
  EFC36189.1  957 TRNSSLKIVNSEFRESEGIACEIRSSQA-FIHNSKFVM-NENAIVAEK-SQLKITNNLITGSK-KKSLLMIQSTGTVQENEIIRNESSGIQLFkECK 1049
                  567778*********************9.*********.999999998.**************.888888999********************88** PP

                  --EEES-EEESTT--SEE---TT---EEES-EEES-SSEEEE-TT-SS--EEES-E. CS
  Beta_helix  102 nntienNiidnnagsGividdsssnvtvtnNtitnnkgaGiavvgsssnvtvrnNti 158 
                  +++i++N+i + +++Giv+++++ + t  +N i++n  aGi+v + ++ + + +N i
  EFC36189.1 1050 DVKITKNVIMGQKAAGIVVNAQC-KATLMHNQIFDNTMAGIEVSNECN-IDIIENEI 1104
                  ***********************.99999999999999**********.**999975 PP

  == domain 4  score: 55.4 bits;  conditional E-value: 2.7e-18
                  -EEES-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-TT-S--EEES-EEESTT--SEE---TT..---EEES-E CS
  Beta_helix   39 neiannsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdnggsGiylnyssnntienNiidnnagsGividdss..snvtvtnNt 133 
                  n i +n++ Gi++++ +n+ i +n+i+ ++  gi +   s+ ++e+n+i++n+ +G++l  +sn ti+nN+i++n++sG++i   +  +++ +++N 
  EFC36189.1 1079 NQIFDNTMAGIEVSNECNIDIIENEIYKGGICGILIATKSRGTVEKNRIYENAYAGLELR-NSNPTIRNNQIYSNRQSGVSIKGKDidNTLIFQGNE 1174
                  556667*****************************************************8.7*********************************** PP

                  EES-SSEEEE-TT-SS CS
  Beta_helix  134 itnnkgaGiavvgsss 149 
                  i +n+  Gi++  +++
  EFC36189.1 1175 ILSNVYSGIEIRQGAT 1190
                  *********9988776 PP

  == domain 5  score: 28.2 bits;  conditional E-value: 6.4e-10
                  SEEE-SS-E.EEESEEEES-SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---..SEEE-TT.--S-- CS
  Beta_helix    2 gisingssnvtiknntisnsggyGiylrgssnvvienneiannsgsGiyilgssnntisnntisdnn..gggialf.gasnn 80  
                  gi++   +  tik n+i n+++ G+++r+ +  +i+ nei+ n+ + iy  ++++ tis+n+is ++  ++ i+++ + +n+
  EFC36189.1 1227 GIIVQKAYA-TIKENKIINNSNMGVKVRQFEADIID-NEISANGSFAIYGDECDRLTISKNKISAHKsvDDPIKIEtNCKNS 1306
                  899999999.**********************6666.**************************9999887777777444444 PP

>> BRCT  BRCA1 C Terminus (BRCT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.4   0.0   1.1e-12   2.4e-09       3      79 .]      26     101 ..      24     101 .. 0.94
   2 !   29.6   0.0   2.9e-10   6.6e-07       6      78 ..     135     204 ..     132     205 .. 0.96
   3 ?   -1.8   0.1       1.9   4.4e+03      26      52 ..     239     283 ..     230     335 .. 0.68

  Alignments for each domain:
  == domain 1  score: 37.4 bits;  conditional E-value: 1.1e-12
                 TTTTTTEEEEE.EESTSSHHHHHHHHHHHHTTCEEESSCSTTSSEEEESSSHSHHHHHHHHHHTTSEEEETHHHHHHH CS
        BRCT   3 ellfhgckfvi.tgvldnftrdeleelikehGGkvttevskktthlvvgepesrslkylealklnipivheewlldci 79 
                 + +++gc+f++ + + ++ + + ++e+ik++GG v+t +++++thl ++    r++++  al+ +++iv+  wl dc+
  EFC36189.1  26 PEFLEGCTFFVdPLTHEEAEAELYREIIKKLGGQVVTMYKSNITHLMASVQ--RGENFYRALEEKKTIVTSFWLDDCM 101
                 5789*******8888888899999************************999..************************6 PP

  == domain 2  score: 29.6 bits;  conditional E-value: 2.9e-10
                 TTTEEEEEEESTSSHHHHHHHHHHHHTTCEEESSCSTTSSEEEESSSHSHHHHHHHHHHTTSEEEETHHHHHH CS
        BRCT   6 fhgckfvitgvldnftrdeleelikehGGkvttevskktthlvvgepesrslkylealklnipivheewlldc 78 
                 ++g++f + +++   +++ l+ li  +G k+++  ++++thl+ +     + ky +++k++i+ v+ +wl+dc
  EFC36189.1 135 MEGFNFTL-SGFPKKEKTRLQYLIAAMGSKYSSNMTQENTHLLYKVA--AGAKYDTSIKWGIKRVDKNWLYDC 204
                 689*****.**********************************8777..78********************** PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.9
                 HHHHHHTTCEE..................ESSCSTTSSEEEESSS CS
        BRCT  26 eelikehGGkv..................ttevskktthlvvgep 52 
                 +++++++ G++                  ++++++ ++ +v+g++
  EFC36189.1 239 KRKLEDNDGSLesiiasntkknifvnldsSDQLKTYCDRVVIGKN 283
                 567777777777777777777777777777777777777777777 PP

>> PTCB-BRCT  twin BRCT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   7.4e-06     0.017      11      63 .]      44      96 ..      37      96 .. 0.89
   2 !   48.7   0.1   2.3e-16   5.2e-13       3      63 .]     140     200 ..     138     200 .. 0.97

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 7.4e-06
                TCHHHHHHHHHHTT-EEESSEETT-SEEEECSS-CHHHHHHHHCT-EEE-CHH CS
   PTCB-BRCT 11 ddrkslqklieamGaeyskdltksvTHLicksgeGekyekAkkwgipvVsveW 63
                 + +  +++i+++G+++++  + ++THL +   +Ge + +A + + ++V+  W
  EFC36189.1 44 AEAELYREIIKKLGGQVVTMYKSNITHLMASVQRGENFYRALEEKKTIVTSFW 96
                456777899********************************999999998766 PP

  == domain 2  score: 48.7 bits;  conditional E-value: 2.3e-16
                 EEEECB-TTCHHHHHHHHHHTT-EEESSEETT-SEEEECSS-CHHHHHHHHCT-EEE-CHH CS
   PTCB-BRCT   3 icvtgysgddrkslqklieamGaeyskdltksvTHLicksgeGekyekAkkwgipvVsveW 63 
                 ++++g+ ++++++lq li amG +ys ++t+++THL  k + G ky+   kwgi+ V  +W
  EFC36189.1 140 FTLSGFPKKEKTRLQYLIAAMGSKYSSNMTQENTHLLYKVAAGAKYDTSIKWGIKRVDKNW 200
                 689*****************************************************99888 PP

>> BRCT_2  BRCT domain, a BRCA1 C-terminus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   1.4e-07   0.00032       4      73 ..      28     101 ..      26     109 .. 0.88
   2 !   14.6   0.0   1.4e-05     0.032      10      80 ..     140     212 ..     135     214 .. 0.90
   3 ?   -1.9   0.1       2.1   4.8e+03      25      62 ..     239     302 ..     232     307 .. 0.45

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.4e-07
      BRCT_2   4 lFeglrFYin.daepspsreklkklIeknGGevvetitsavyiviaesneee...laekrkrrvvspkyIkdCi 73 
                 + eg++F++   ++ +++ e ++++I+k GG+vv   +s+ ++++a+ +  e    a ++k+ +v+  +++dC 
  EFC36189.1  28 FLEGCTFFVDpLTHEEAEAELYREIIKKLGGQVVTMYKSNITHLMASVQRGEnfyRALEEKKTIVTSFWLDDCM 101
                 4599*****8766777999999*************9999988988888877799*9999**************6 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1.4e-05
      BRCT_2  10 FYindaepspsreklkklIeknGGevvetitsavyiviaesneee...laekrkrrvvspkyIkdCikkgkllp 80 
                 F + + +p++++ +l+ lI + G + ++++t+++++++++        ++ k + + v+ ++++dC +  kl p
  EFC36189.1 140 FTL-SGFPKKEKTRLQYLIAAMGSKYSSNMTQENTHLLYKVAAGAkydTSIKWGIKRVDKNWLYDCARDWKLAP 212
                 555.678999*****************************999877999999****************9988876 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2.1
      BRCT_2  25 kklIeknGGevveti...................tsavyiviaesneee.......laekrkrr 62 
                 k++ e+n+G +++ i                   t ++ +vi ++n++        +a++++++
  EFC36189.1 239 KRKLEDNDGSLESIIasntkknifvnldssdqlkTYCDRVVIGKNNSKVllvennpTAQNEDEK 302
                 5677788887744443332333333333333333222223333332222444444445555555 PP

>> LIG3_BRCT  DNA ligase 3 BRCT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0    0.0019       4.3       5      76 ..      28     101 ..      24     104 .. 0.75
   2 !   14.4   0.0   1.6e-05     0.035      21      77 ..     150     206 ..     136     210 .. 0.86
   3 ?   -2.6   0.0       3.2   7.2e+03      67      80 ..     388     401 ..     386     402 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0019
   LIG3_BRCT   5 iFtgvklfipksv..edykklrRYfi.AydGdlvkeekekeaTHvvvskkeeskkekeksknakaVtaewiwesI 76 
                   +g++ f+ +    e+ + l+R +i   +G++v+ + ++++TH ++s ++ ++   + +++ + Vt+ w++++ 
  EFC36189.1  28 FLEGCTFFVDPLTheEAEAELYREIIkKLGGQVVTMY-KSNITHLMASVQRGENFYRALEEKKTIVTSFWLDDCM 101
                 5678888887766433444666666625899999955.578*******88877778888889999********96 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.6e-05
   LIG3_BRCT  21 kklrRYfiAydGdlvkeekekeaTHvvvskkeeskkekeksknakaVtaewiwesIk 77 
                 k   +Y+iA  G+ +++++++e TH + +     k  ++ + + k+V  +w+ ++ +
  EFC36189.1 150 KTRLQYLIAAMGSKYSSNMTQENTHLLYKVAAGAKYDTSIKWGIKRVDKNWLYDCAR 206
                 44448************************8878889999999*************87 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 3.2
   LIG3_BRCT  67 VtaewiwesIkkrt 80 
                 V  ++iw+ I++++
  EFC36189.1 388 VRISHIWNMIQEHN 401
                 7789******9876 PP

>> RTT107_BRCT_5  Regulator of Ty1 transposition protein 107 BRCT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0     1e-07   0.00023      31      88 ..      45     102 ..      32     125 .. 0.85
   2 ?   -2.1   0.0       1.6   3.6e+03       8      39 ..     147     176 ..     143     205 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1e-07
                    SSHHHHHHHHHTTEEE-SGCCT.-SEEE-SS---SHHHHHHCCCTTEEE-CHHHHHHHH CS
  RTT107_BRCT_5  31 kedsdkkkLrklGikivqeakk.cntliApkilRTeKFLksLskapkilspdfiedvLk 88 
                    + +  +++++klG ++v+ +k+ +++l+A ++ R e F ++L  +++i+++ +++d++ 
     EFC36189.1  45 EAELYREIIKKLGGQVVTMYKSnITHLMA-SVQRGENFYRALEEKKTIVTSFWLDDCML 102
                    6778899***********77666******.599************************86 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.6
                    HTSSSXXX--EEEEESSS.TT..SSHHHHHHH CS
  RTT107_BRCT_5   8 kkkkskpevkiravlTgceeevnkedsdkkkL 39 
                    kk+k++ ++ i a+ ++++++  +++++++ L
     EFC36189.1 147 KKEKTRLQYLIAAMGSKYSSN--MTQENTHLL 176
                    678888889999999999888..455455544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       811  (0.045234); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.86u 0.39s 00:00:01.25 Elapsed: 00:00:00.54
# Mc/sec: 7306.79
//
Query:       EFC36190.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0041   17.3   8.6     0.0073   16.5   8.6    1.5  1  Tropomyosin_1    Tropomyosin like
     0.0086   16.1   6.6      0.015   15.4   6.6    1.3  1  DUF1664          Protein of unknown function (DUF1664)
  ------ inclusion threshold ------
       0.04   14.4   2.5       0.04   14.4   2.5    2.5  3  NPV_P10          Nucleopolyhedrovirus P10 protein
       0.17   11.9   2.7        9.4    6.3   0.1    3.0  3  RNR_N            Ribonucleotide reductase N-terminal
       0.21   12.0   4.0        4.8    7.6   0.9    2.5  2  CLZ              C-terminal leucine zipper domain of cyclic n
       0.22   11.4  10.1        3.2    7.6  10.1    2.2  1  CdvA             CdvA-like coiled-coil domain
       0.48   10.6   4.8       0.24   11.6   0.7    2.1  2  DUF3213          Protein of unknown function (DUF3213)
       0.57    9.9   6.5        2.8    7.6   0.1    3.4  2  Vac_Fusion       Chordopoxvirus multifunctional envelope prot
        1.3    9.8   7.4       0.61   10.9   3.8    2.3  2  TORC_N           Transducer of regulated CREB activity, N ter
        1.5    9.3  13.3        1.1    9.8   5.2    3.5  4  Snapin_Pallidin  Snapin/Pallidin
          2    8.7   8.1        4.1    7.7   1.8    2.6  2  XhlA             Haemolysin XhlA
        2.9    7.6   7.8       0.82    9.4   4.4    1.8  1  EMC3_TMCO1       Integral membrane protein EMC3/TMCO1-like
        3.6    7.9   7.0         22    5.4   1.1    2.7  2  Osmo_CC          Osmosensory transporter coiled coil
        6.7    7.0  10.6        2.5    8.4   4.4    2.7  3  ABC_tran_CTD     ABC transporter C-terminal domain


Domain annotation for each model (and alignments):
>> Tropomyosin_1  Tropomyosin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   8.6   5.7e-06    0.0073       8      97 ..      57     153 ..      48     169 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 5.7e-06
  Tropomyosin_1   8 eaeeaqekaeeleekvKeleqenlekeqeiks....Ltkknqqleeevekleeklkeakekaeesekkktnne...altrkiqlLEeeleesdkkL 96 
                    ++e    k ++leekv + +q++ e+ +e++s    L kk++ +e+ +ek +  ++e+ + +++++ kk++ e   ++t+ +q  E  ++e   +L
     EFC36190.1  57 DKEWFTLKFQNLEEKVASVQQKQNEMQEELSSvminLMKKMDSIESVLEKHQFMIEEQYSMLSDKNVKKASFEssqSITKCVQDCEHKIDEIKLHL 152
                    677777899999999999999999999998765555899999999999999999999999999999999999988899999999999999877776 PP

  Tropomyosin_1  97 k 97 
                     
     EFC36190.1 153 D 153
                    5 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   6.6   1.1e-05     0.015      37     121 ..      66     149 ..      59     152 .. 0.91

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 1.1e-05
     DUF1664  37 rslsdavesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveglesklerie 121
                 ++l++ v+sv ++ ++++e+l+++  +L++++d++++ l++ + +++e  + +++ + + ++++  ++s+ + v++ e+k+++i+
  EFC36190.1  66 QNLEEKVASVQQKQNEMQEELSSVMINLMKKMDSIESVLEKHQFMIEEQYSMLSDKNVKKASFE-SSQSITKCVQDCEHKIDEIK 149
                 79*******************************************9999999988777766665.579**************996 PP

>> NPV_P10  Nucleopolyhedrovirus P10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   2.5   3.1e-05      0.04      14      67 ..      66     120 ..      64     127 .. 0.90
   2 ?    3.1   0.1      0.11   1.4e+02       9      44 ..     134     169 ..     130     175 .. 0.62
   3 ?   -2.8   0.0       7.4   9.5e+03       3      12 ..     191     200 ..     187     206 .. 0.61

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 3.1e-05
     NPV_P10  14 kavddkVdalqqqvddvqenlpdvt.elnekLdaqsaqLaeletkvenIqdiLnp 67 
                 +++++kV ++qq+ +++qe+l  v  +l +k+d++   L++ +  +e+  ++L+ 
  EFC36190.1  66 QNLEEKVASVQQKQNEMQEELSSVMiNLMKKMDSIESVLEKHQFMIEEQYSMLSD 120
                 6899******************9864799*******************9999994 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.11
     NPV_P10   9 IradikavddkVdalqqqvddvqenlpdvtelnekL 44 
                 I + +++ + k+d ++ ++d ++ +     el ekL
  EFC36190.1 134 ITKCVQDCEHKIDEIKLHLDTLERKQVYEPELIEKL 169
                 555666666777777777776665544445555555 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 7.4
     NPV_P10   3 qniLlvIrad 12 
                 q  L  I++d
  EFC36190.1 191 QKFLQNILDD 200
                 5555555554 PP

>> RNR_N  Ribonucleotide reductase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.75   9.6e+02      38      53 ..      62      77 ..      59      88 .. 0.80
   2 ?    5.2   0.1     0.017        22      36      78 ..      95     139 ..      84     143 .. 0.72
   3 ?    6.3   0.1    0.0074       9.4      32      66 ..     136     170 ..     129     180 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.75
       RNR_N 38 tvkfesleekldyLve 53
                t kf++leek+    +
  EFC36190.1 62 TLKFQNLEEKVASVQQ 77
                6789999999976654 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.017
       RNR_N  36 pntvkfesleekldyLvendY..yeeevlekYskefieelyklay 78 
                 +++   es+ ek ++++e++Y    ++ ++k s+e  ++++k ++
  EFC36190.1  95 KKMDSIESVLEKHQFMIEEQYsmLSDKNVKKASFESSQSITKCVQ 139
                 6777889999**********9443444446767776666666665 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0074
       RNR_N  32 ehvnpntvkfesleekldyLvendYyeeevlekYs 66 
                 + v++   k ++++ +ld L +++ ye+e++ek +
  EFC36190.1 136 KCVQDCEHKIDEIKLHLDTLERKQVYEPELIEKLE 170
                 668999999**********************9865 PP

>> CLZ  C-terminal leucine zipper domain of cyclic nucleotide-gated channels
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.9    0.0037       4.8      31      69 ..      63     101 ..      50     103 .. 0.81
   2 ?    4.7   0.1     0.031        40      25      46 ..     137     158 ..     120     160 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0037
         CLZ  31 ekverLessLeaLqtrlarLlaeyessqrkLkqRitkLE 69 
                  k ++Le+++ + q++ + + +e++s+   L++++  +E
  EFC36190.1  63 LKFQNLEEKVASVQQKQNEMQEELSSVMINLMKKMDSIE 101
                 577889999999999999999999999988888888887 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.031
         CLZ  25 eqkeleekverLessLeaLqtr 46 
                   ++ e+k+++++ +L++L+ +
  EFC36190.1 137 CVQDCEHKIDEIKLHLDTLERK 158
                 5578999999999999999876 PP

>> CdvA  CdvA-like coiled-coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6  10.1    0.0025       3.2      25     119 ..      66     166 ..      53     170 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0025
        CdvA  25 ekleealkklkekakelkeklkkrlkeledqikslekal....anlkisyasGEidEeaYksa....ieairellesaleekeeikklleklsklelee 115
                 ++lee+++ +++k++e +e+l++ +  l ++++s+e++l    + ++ +y    +++++ k+a    +++i++  + ++++++eik +l++l+  +  e
  EFC36190.1  66 QNLEEKVASVQQKQNEMQEELSSVMINLMKKMDSIESVLekhqFMIEEQYS--MLSDKNVKKAsfesSQSITKCVQDCEHKIDEIKLHLDTLERKQVYE 162
                 567777777777777777777777777777777776654111144444443..355555444311115678899999***************9877766 PP

        CdvA 116 eeve 119
                 +e +
  EFC36190.1 163 PELI 166
                 6655 PP

>> DUF3213  Protein of unknown function (DUF3213)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.7   0.00018      0.24       2      56 ..      63     119 ..      62     135 .. 0.87
   2 ?    0.0   0.2      0.77   9.9e+02      41      65 ..     145     168 ..     134     174 .. 0.53

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00018
                 EE--S-TTTTTHHHHHTTTTTTTB------TTSS--..EEE--B-S-SHHHHHHHT. CS
     DUF3213   2 lkftdltpekakikqyelekdervyrvflngyakva..evvideekvnieelkkkle 56 
                 lkf +l+ + a ++q + e +e++  v++n   k    e v++++++ iee    l 
  EFC36190.1  63 LKFQNLEEKVASVQQKQNEMQEELSSVMINLMKKMDsiESVLEKHQFMIEEQYSMLS 119
                 8*****************************99997622669*********9887774 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.77
                 --B-S-SHHHHHHHT...TT-SS-- CS
     DUF3213  41 ideekvnieelkkkleelkgevvee 65 
                 ide k+  + l +k     +e++e+
  EFC36190.1 145 IDEIKLHLDTLERKQ-VYEPELIEK 168
                 444444444444443.344555444 PP

>> Vac_Fusion  Chordopoxvirus multifunctional envelope protein A27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   2.5      0.21   2.7e+02      42      52 ..      88      98 ..      57     100 .. 0.61
   2 ?    7.6   0.1    0.0022       2.8      17      42 ..     132     157 ..     127     161 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.21
                XXXXXXXXXXX CS
  Vac_Fusion 42 kamlaLakKID 52
                  m++L kK D
  EFC36190.1 88 SVMINLMKKMD 98
                34666666665 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0022
                 HHHHHHHHHHHHHHHHHH-XXXXXXX CS
  Vac_Fusion  17 qlvikcckrvnealkRlEnHleTlRk 42 
                 q ++kc +  +  ++ +  Hl+Tl +
  EFC36190.1 132 QSITKCVQDCEHKIDEIKLHLDTLER 157
                 789********************955 PP

>> TORC_N  Transducer of regulated CREB activity, N terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1       2.8   3.6e+03      39      55 ..      21      37 ..      16      52 .. 0.59
   2 ?   10.9   3.8   0.00048      0.61       7      36 ..      70      99 ..      64     137 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 2.8
      TORC_N 39 qssnaksaaalaiPkqq 55
                +s++++s++a+ +P+q+
  EFC36190.1 21 DSNKQSSQNATGVPHQN 37
                44444444556666664 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00048
      TORC_N  7 EKIAlhnqKqaEetaaFekimrevsaatrk 36
                EK+A  +qKq+E +++  ++m ++++   +
  EFC36190.1 70 EKVASVQQKQNEMQEELSSVMINLMKKMDS 99
                9********************999875443 PP

>> Snapin_Pallidin  Snapin/Pallidin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   5.2   0.00083       1.1      14      43 ..      64      93 ..      59     113 .. 0.75
   2 ?    0.0   0.2       0.9   1.2e+03      46      69 ..     131     149 ..      97     158 .. 0.46
   3 ?    0.4   0.0       0.7   8.9e+02      12      30 ..     142     160 ..     137     170 .. 0.78
   4 ?    1.5   0.1      0.31     4e+02      26      51 ..     188     213 ..     175     218 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00083
  Snapin_Pallidin 14 kldeldeklkelrqsQeeLleqldrlnekL 43
                     k ++l+ek+++++q+Q+e++e+l++   +L
       EFC36190.1 64 KFQNLEEKVASVQQKQNEMQEELSSVMINL 93
                     67899*****************99865555 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.9
  Snapin_Pallidin  46 leeaqeaevlpdlkeyakKLvnik 69 
                       + +++      ++    K+ +ik
       EFC36190.1 131 SQSITK-----CVQDCEHKIDEIK 149
                      333333.....2233333343333 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.7
  Snapin_Pallidin  12 epkldeldeklkelrqsQe 30 
                      e k+de++ +l  l+++Q 
       EFC36190.1 142 EHKIDEIKLHLDTLERKQV 160
                      6688888888888888885 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.31
  Snapin_Pallidin  26 rqsQeeLleqldrlnekLkeleeaqe 51 
                       +sQ+ L++ ld  +++L + ++ ++
       EFC36190.1 188 STSQKFLQNILDDKASQLVKPRKQEP 213
                      579************99987666655 PP

>> XhlA  Haemolysin XhlA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   1.8    0.0032       4.1      14      45 ..      66     101 ..      63     105 .. 0.70
   2 ?    4.1   0.5     0.041        53       3      28 ..     135     160 ..     133     172 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0032
        XhlA  14 dnleervdkleekaaeaeeki....knleedlkkle 45 
                  nlee+v  +++k++e++e++    +nl ++++++e
  EFC36190.1  66 QNLEEKVASVQQKQNEMQEELssvmINLMKKMDSIE 101
                 699999**********99998222234555555555 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.041
        XhlA   3 kerlerietkldnleervdkleekaa 28 
                  + ++ +e k+d+++  +d+le+k+ 
  EFC36190.1 135 TKCVQDCEHKIDEIKLHLDTLERKQV 160
                 56678899999999999999999985 PP

>> EMC3_TMCO1  Integral membrane protein EMC3/TMCO1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   4.4   0.00064      0.82      55      95 ..      57      97 ..      37     104 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00064
  EMC3_TMCO1 55 qkrarelqkngdklklkklekrqeelmedqsemmmdqmkpm 95
                 k+   l+ ++ ++k ++++++q+e++e+ s++m + mk+m
  EFC36190.1 57 DKEWFTLKFQNLEEKVASVQQKQNEMQEELSSVMINLMKKM 97
                555556666888999************************99 PP

>> Osmo_CC  Osmosensory transporter coiled coil
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   1.1     0.017        22      13      33 ..      64      84 ..      58     112 .. 0.81
   2 ?    5.2   0.5      0.02        26      15      34 ..     139     158 ..     135     168 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.017
                XXTHHHHHHHHHHHHHHHHHH CS
     Osmo_CC 13 hYdnIEqkvedideeIaaLee 33
                +++n E+kv  + +  ++++e
  EFC36190.1 64 KFQNLEEKVASVQQKQNEMQE 84
                79*************999999 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.02
                 THHHHHHHHHHHHHHHHHHH CS
     Osmo_CC  15 dnIEqkvedideeIaaLeek 34 
                 ++ E+k+++i   +  Le k
  EFC36190.1 139 QDCEHKIDEIKLHLDTLERK 158
                 678*************9987 PP

>> ABC_tran_CTD  ABC transporter C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   4.4    0.0019       2.5       9      58 ..      64     112 ..      58     117 .. 0.74
   2 ?    3.8   0.5     0.053        68       8      59 ..      95     147 ..      91     161 .. 0.81
   3 ?   -1.4   0.1       2.2   2.9e+03      14      22 ..     163     171 ..     152     194 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0019
  ABC_tran_CTD   9 eleeleaeIeaLEeeiaeleaeladpelysdpeklaelsaeleeleaeLe 58 
                   ++++le++ ++ ++++ e+++el++  + +  +k+  +   le+ +  +e
    EFC36190.1  64 KFQNLEEKVASVQQKQNEMQEELSSVMI-NLMKKMDSIESVLEKHQFMIE 112
                   5789********************8743.344666666655655555555 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.053
  ABC_tran_CTD   8 releeleaeIeaLEeeiaeleaeladpelysdp.eklaelsaeleeleaeLee 59 
                   ++++ +e+ +e+ +  i+e    l+d ++ + + e  + +++  ++ e++++e
    EFC36190.1  95 KKMDSIESVLEKHQFMIEEQYSMLSDKNVKKASfESSQSITKCVQDCEHKIDE 147
                   67888999999999999999999999999866669988888888888888776 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 2.2
  ABC_tran_CTD  14 eaeIeaLEe 22 
                   ++ Ie+LE 
    EFC36190.1 163 PELIEKLEI 171
                   567788775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2342  (0.130626); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 1271.23
//
Query:       EFC36191.1  [L=274]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00022   20.8   0.0     0.0025   17.3   0.0    2.2  2  SBP_bac_3  Bacterial extracellular solute-binding proteins, f
  ------ inclusion threshold ------
      0.053   13.5   0.0       0.09   12.7   0.0    1.5  1  MTP18      Mitochondrial 18 KDa protein (MTP18)
      0.079   13.8   0.0       0.27   12.1   0.0    1.8  2  zf-PARP    Poly(ADP-ribose) polymerase and DNA-Ligase Zn-fing


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.026   1.5e+02      47      78 ..     132     163 ..     105     165 .. 0.78
   2 !   17.3   0.0   4.1e-07    0.0025     113     189 ..     165     239 ..     149     246 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.026
                 GGGHHHHHHTTSSSEEESSEB--HHHHTTEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3  47 wdelipalksgkvDiaiaaititpeReekvdF 78 
                 ++ + +a+++g +D+  +a++i+ +R  +v F
  EFC36191.1 132 FSVMKNAVDTGICDVSLSATAISGDRPSQVHF 163
                 56667899******************999988 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 4.1e-07
                 EEEETTSHHHHHHHHHHHCTSEEEEESSHHHHHHHHHTTSSSEEEEEHHHHHHHHHHCCGCCEEEEECGGCECEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 113 vgvqagstaeellkeelkkgaeivefdtleealqaLkngrvdavvadspvlaylvkknpdkkvvlveeplsseeyai 189
                  +v+ gs+ +++++++l+ +a+i++ + +++a +++ n+ + a+vad   l+ +v+ ++   ++  ++ l+++e+ +
  EFC36191.1 165 FVVSDGSVFQSYAQQQLP-KATIKSIPGYDDAWNMILNKTAHAFVADALDLYVWVRYHKSSCATC-KVILFGDELRF 239
                 57999*********9888.89***********************************999988877.66666666655 PP

>> MTP18  Mitochondrial 18 KDa protein (MTP18)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.5e-05      0.09      95     133 ..     157     195 ..      90     216 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.5e-05
       MTP18  95 veeledyrlvmakravFqsiASmaLPaltiHsvVkysgk 133
                  ++  +++ v+   +vFqs A   LP  ti s+  y + 
  EFC36191.1 157 RPSQVHFQFVVSDGSVFQSYAQQQLPKATIKSIPGYDDA 195
                 455678999***********************9877554 PP

>> zf-PARP  Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.3   7.6e+03      61      78 ..     184     208 ..     172     212 .. 0.60
   2 ?   12.1   0.0   4.5e-05      0.27       7      38 ..     222     255 ..     219     262 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.3
                 .....EETTTT.....S-HHHHHHH CS
     zf-PARP  61 e..eeiegfee.....Lekedqekv 78 
                 +  ++i+g+++     L+k+ ++ v
  EFC36191.1 184 AtiKSIPGYDDawnmiLNKTAHAFV 208
                 1348899999866666666655555 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 4.5e-05
                 --B-SSS--B--SSSEEEEE-...---..---EE CS
     zf-PARP   7 rakCkkCkkkIakgelRlgkkveiees..eskrW 38 
                 +++C  Ck+    +elR+g+ ++ + +     +W
  EFC36191.1 222 KSSCATCKVILFGDELRFGTFITNQFQssSVSTW 255
                 79******************87665545444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       645  (0.0359752); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1677.26
//
Query:       EFC36192.1  [L=727]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.8e-34  116.0   2.2    6.9e-05   22.7   0.0    7.0  6  NHL           NHL repeat
    2.8e-11   43.6   8.0    6.1e-11   42.5   1.3    2.5  2  BTB           BTB/POZ domain
    0.00011   21.9   0.5        6.1    6.3   0.0    4.4  4  SGL           SMP-30/Gluconolactonase/LRE-like region
    0.00022   20.9   5.1       0.77    9.3   0.0    4.9  5  AA_kinase     Amino acid kinase family
     0.0055   16.1   0.3         19    4.5   0.0    4.1  5  DUF2092       Predicted periplasmic protein (DUF2092)
  ------ inclusion threshold ------
      0.021   14.8   0.1        1.8    8.4   0.0    3.6  3  Phytase-like  Esterase-like activity of phytase
      0.029   14.6  12.7         20    5.5   0.1    6.0  6  TRL           TRL-like protein family
      0.084   13.2   0.0         94    3.4   0.0    4.1  4  DUF5485       Family of unknown function (DUF5485)
       0.41   10.5   6.0        9.4    6.1   0.1    4.6  6  NPH-II        RNA helicase NPH-II


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   4.3e-07   0.00086       4      27 ..      10      34 ..       9      35 .. 0.88
   2 !   12.5   0.0   5.8e-05      0.12       9      27 ..      72      90 ..      64      91 .. 0.86
   3 !   22.2   0.0   4.8e-08   9.6e-05       1      27 [.     120     146 ..     120     147 .. 0.93
   4 !   22.7   0.0   3.5e-08   6.9e-05       4      27 ..     179     202 ..     178     203 .. 0.92
   5 !   12.5   0.0   5.7e-05      0.11       1      27 [.     232     258 ..     232     259 .. 0.92
   6 !   19.9   0.0   2.6e-07   0.00053       1      27 [.     288     314 ..     288     315 .. 0.94

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 4.3e-07
                EEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL  4 PhGvavd.snGdiyVaDsenhrvqv 27
                P+++ v+ sn+++y+aD++nh+v++
  EFC36192.1 10 PRSIFVSsSNDEVYIADTGNHTVRK 34
                77777888***************87 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 5.8e-05
                EETTTEEEEEECCCTEEEE CS
         NHL  9 vdsnGdiyVaDsenhrvqv 27
                v+s +++y+aD+ n+r+++
  EFC36192.1 72 VSSKNEVYIADYQNNRIRK 90
                789**************97 PP

  == domain 3  score: 22.2 bits;  conditional E-value: 4.8e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P++v+v+  +++y+aDs+nh++++
  EFC36192.1 120 LASPSSVCVSLKNEVYIADSGNHSIRK 146
                 678**********************87 PP

  == domain 4  score: 22.7 bits;  conditional E-value: 3.5e-08
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P++v v++n+++y+aD++nhr+++
  EFC36192.1 179 PSSVFVTPNDEVYIADTGNHRIRK 202
                 889999****************97 PP

  == domain 5  score: 12.5 bits;  conditional E-value: 5.7e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P +v v+s +++y+aD+ n r+++
  EFC36192.1 232 LSSPVDVFVSSKNEVYIADYQNTRIRK 258
                 678*******************99986 PP

  == domain 6  score: 19.9 bits;  conditional E-value: 2.6e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P Gv v++++++y+aD+ n+r+++
  EFC36192.1 288 LYSPVGVFVSQDNEVYIADYQNNRIRK 314
                 689**********************97 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.8     0.021        43      32     107 ..     381     456 ..     371     460 .. 0.74
   2 !   42.5   1.3   3.1e-14   6.1e-11       3     107 ..     553     659 ..     551     662 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.021
                 HH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHH.HHSEEEC-.CGGGHHHHHHHHHHHT-H...HHHHHHHHHH CS
         BTB  32 arSpyFkalftskeieessvseielddvepeafealLefi.Ytgeleit.seenleelLaaadllqip...rlkkaceefl 107
                 + Sp F + + ++   es      ++ ++ e++++l++ + Y  e++++ + +++ ++L +  +++ +   +lkk+c++ +
  EFC36192.1 381 MVSPLFCKYILKN---ESLI--SSMNSIQQEIIQKLIDSLiYNNEIQLKfNNDEILDVLFILGFFKNNefiQLKKLCTTQF 456
                 5688888888888...3332..35699**********9765*******988889999999888886541114555566555 PP

  == domain 2  score: 42.5 bits;  conditional E-value: 3.1e-14
                 HHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST.TTTTCCCE.EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHH CS
         BTB   3 elresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk.eieessvs.eielddvepeafealLefiYtgeleitseenleelLaaadllqiprl 99 
                 +l + ++ +D+ ++++++  +++hk +L+++S+ F+a+f s+ ++++ s++  i+ +  ++e +e++++ +Y   ++  + e+l  lL +a + +++ l
  EFC36192.1 553 KLYNDKKTSDLKIQIDEDNYLYCHKTILSSSSTLFNAMFDSGsTFTDLSNDiFIPDSSDDFEFLEIIIKTCYETPVQDVKYEKLLRLLDMAMKHEMEYL 651
                 5778899***********************************75555554435555566799************9999999****************** PP

                 HHHHHHHH CS
         BTB 100 kkaceefl 107
                 +k c++ l
  EFC36192.1 652 VKYCKNEL 659
                 ****9987 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.025        50     141     218 ..      15      99 ..       6     106 .. 0.65
   2 !    6.3   0.0    0.0031       6.1     146     218 ..     132     211 ..     109     218 .. 0.78
   3 ?    0.2   0.0      0.23   4.7e+02     190     218 ..     239     267 ..     233     272 .. 0.88
   4 !    5.1   0.0    0.0073        15     186     218 ..     291     323 ..     270     326 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.025
         SGL 141 wspdgktlYlaDsltrkiwaydvdaeggkls.nrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 +s+ ++ +Y+aD+ ++++ ++  + +  ++  n +  + +++g         p  ++v ++++v++A +++++++++ ++G++i+
  EFC36192.1  15 VSSSNDEVYIADTGNHTVRKILENGNIVTIAgNGQQGYSGDNGLavnaqlVSPSYVFVSSKNEVYIADYQNNRIRKILENGNIIT 99 
                 5666777777777777766665544444433033333666666666665533666788888888888888888888888888775 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0031
         SGL 146 ktlYlaDsltrkiwaydvdaeggkls.nrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 + +Y+aDs +++i ++  + +  ++  n +  +++++g+        p +++v+ +++v++A  g+++++++  +G++i+
  EFC36192.1 132 NEVYIADSGNHSIRKILENGNIVTIAgNGQQGYNGDNGPavnaplFDPSSVFVTPNDEVYIADTGNHRIRKILRNGNIIT 211
                 468999999999999876666555541555558888888888876558899************************99886 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.23
         SGL 190 avDaeGnvwvAvwgggkvvrfdpdGklie 218
                 +v ++++v++A +++ +++++ ++G++i+
  EFC36192.1 239 FVSSKNEVYIADYQNTRIRKILENGNIIT 267
                 67889999************999999886 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0073
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 p G++v ++++v++A +++++++++ ++G++i+
  EFC36192.1 291 PVGVFVSQDNEVYIADYQNNRIRKILENGNIIT 323
                 6699*************************9886 PP

>> AA_kinase  Amino acid kinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0   0.00039      0.77     128     193 ..      29      86 ..       3      94 .. 0.81
   2 ?    2.6   0.0     0.044        89     127     164 ..      84     114 ..      79     139 .. 0.72
   3 ?    3.4   0.1     0.024        48     129     193 ..     142     198 ..     115     217 .. 0.79
   4 ?   -0.9   0.0      0.51     1e+03     129     148 ..     198     219 ..     171     250 .. 0.79
   5 ?    2.7   0.0     0.041        81     126     154 ..     307     335 ..     283     342 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00039
                 CCHHHHHHHTT-EEEEESEEEEETTTEEEEE-HHHHHHHHHHHCTSSEEEEEESSSSCESSTTTTC CS
   AA_kinase 128 aeaieelleagvvpvltgfigldeegelgrgssDtiaallAealgAdkliiltdVdGVydadpkkv 193
                   +++++le+g+++ ++g++   ++g     s+D   a  A+++++ +++++++ + Vy ad   +
  EFC36192.1  29 NHTVRKILENGNIVTIAGNG---QQGY----SGDNGLAVNAQLVSP-SYVFVSSKNEVYIADYQNN 86 
                 6799**************99...5555....9**************.99999*******9997665 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.044
                 ECCHHHHHHHTT-EEEEESEE..EEETTTEEEEE-HHHHH CS
   AA_kinase 127 daeaieelleagvvpvltgfi..gldeegelgrgssDtia 164
                 + + i+++le+g+++ ++g++  g++ +++          
  EFC36192.1  84 QNNRIRKILENGNIITIAGNGqqGYNGDNG---------L 114
                 5689***************98444444443.........3 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.024
                 CHHHHHHHTT-EEEEESEEEEETTTEEEEE-HHHHHHHHHHHCTSSEEEEEESSSSCESSTTTTC CS
   AA_kinase 129 eaieelleagvvpvltgfigldeegelgrgssDtiaallAealgAdkliiltdVdGVydadpkkv 193
                   i+++le+g+++ ++g++   ++g     ++D   a  A ++++ + +++t  d Vy ad   +
  EFC36192.1 142 HSIRKILENGNIVTIAGNG---QQGY----NGDNGPAVNAPLFDP-SSVFVTPNDEVYIADTGNH 198
                 5799*************98...4544....888888888888888.7778888888888887666 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.51
                 CHHHHHHHTT-EEEEESEE..E CS
   AA_kinase 129 eaieelleagvvpvltgfi..g 148
                   i+++l +g+++ ++g++  g
  EFC36192.1 198 HRIRKILRNGNIITIAGNGqqG 219
                 5799999999999999987333 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.041
                 EECCHHHHHHHTT-EEEEESEEEEETTTE CS
   AA_kinase 126 vdaeaieelleagvvpvltgfigldeege 154
                 ++ + i+++le+g+++ ++g++ l  +g+
  EFC36192.1 307 YQNNRIRKILENGNIITIAGNGELGYDGD 335
                 55799***************995555544 PP

>> DUF2092  Predicted periplasmic protein (DUF2092)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.051     1e+02      49      83 ..      19      53 ..       4      65 .. 0.88
   2 ?   -1.2   0.0      0.55   1.1e+03      37      82 ..      63     108 ..      58     112 .. 0.84
   3 ?    3.8   0.0     0.016        31      36      84 ..     118     166 ..     109     178 .. 0.89
   4 !    4.5   0.0    0.0097        19      43      88 ..     181     226 ..     174     239 .. 0.89
   5 ?   -2.9   0.0       1.7   3.4e+03      44      77 ..     294     327 ..     282     332 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.051
     DUF2092 49 PdklrvdtsgdekdrefyyDGktftlydkaenvYa 83
                 d++++  +g +++r+++ +G  +t+ ++ ++ Y+
  EFC36192.1 19 NDEVYIADTGNHTVRKILENGNIVTIAGNGQQGYS 53
                68999999********************9999996 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.55
     DUF2092  37 qfsasrevkvqrPdklrvdtsgdekdrefyyDGktftlydkaenvY 82 
                 q+++ + v v+  +++++     ++ r+++ +G  +t+ ++ ++ Y
  EFC36192.1  63 QLVSPSYVFVSSKNEVYIADYQNNRIRKILENGNIITIAGNGQQGY 108
                 66666778888889999999999999************99999888 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.016
     DUF2092  36 lqfsasrevkvqrPdklrvdtsgdekdrefyyDGktftlydkaenvYaq 84 
                 +q+ + ++v v+  +++++  sg ++ r+++ +G  +t+ ++ ++ Y  
  EFC36192.1 118 AQLASPSSVCVSLKNEVYIADSGNHSIRKILENGNIVTIAGNGQQGYNG 166
                 6788889999********************************9999975 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.0097
     DUF2092  43 evkvqrPdklrvdtsgdekdrefyyDGktftlydkaenvYaqapap 88 
                 +v v+  d++++  +g ++ r+++ +G  +t+ ++ ++ Y+  + p
  EFC36192.1 181 SVFVTPNDEVYIADTGNHRIRKILRNGNIITIAGNGQQGYSGDNGP 226
                 6788999*******************************99866655 PP

  == domain 5  score: -2.9 bits;  conditional E-value: 1.7
     DUF2092  44 vkvqrPdklrvdtsgdekdrefyyDGktftlydk 77 
                 v v++ +++++     ++ r+++ +G  +t+ ++
  EFC36192.1 294 VFVSQDNEVYIADYQNNRIRKILENGNIITIAGN 327
                 7788899999999999999999999999998765 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.57   1.1e+03      72     100 ..      12      41 ..       4      61 .. 0.87
   2 ?    8.4   0.0   0.00091       1.8      43     101 ..     152     210 ..      71     215 .. 0.83
   3 ?   -0.2   0.0      0.39   7.8e+02      72     101 ..     293     322 ..     239     325 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.57
  Phytase-like  72 giav.apdgtfwvssEggpfilefdadGkl 100
                   +i v ++++++++++ g++ ++++  +G++
    EFC36192.1  12 SIFVsSSNDEVYIADTGNHTVRKILENGNI 41 
                   677778999***************999987 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00091
  Phytase-like  43 klgkveitevtplkdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdadGkll 101
                   ++ +++ +++   + ++g +++   +Dp ++ v+p++++++++ g+++i+++ ++G+++
    EFC36192.1 152 NIVTIAGNGQQGYNGDNGPAVNAPLFDPSSVFVTPNDEVYIADTGNHRIRKILRNGNII 210
                   44455555555556666666655667*****************************9985 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.39
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkll 101
                   g+ v++d+++++++ ++++i+++  +G+++
    EFC36192.1 293 GVFVSQDNEVYIADYQNNRIRKILENGNII 322
                   566789999999999999999999999875 PP

>> TRL  TRL-like protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.05     1e+02      27      54 ..      18      45 ..       9      46 .. 0.84
   2 ?    1.5   0.1      0.18   3.6e+02      28      54 ..      75     101 ..      66     102 .. 0.85
   3 ?    5.5   0.1      0.01        20      31      54 ..     134     157 ..     115     158 .. 0.86
   4 ?    4.8   0.1     0.017        33      32      54 ..     191     213 ..     187     214 .. 0.90
   5 ?    0.9   0.0      0.28   5.7e+02      28      54 ..     243     269 ..     224     270 .. 0.85
   6 ?    0.7   0.1      0.32   6.3e+02      32      54 ..     303     325 ..     296     327 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.05
         TRL 27 aksiLglvstGdaSieaaaknggItkia 54
                ++   ++  tG+  ++++ +ng+I +ia
  EFC36192.1 18 SNDEVYIADTGNHTVRKILENGNIVTIA 45
                455568899***************9996 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.18
         TRL  28 ksiLglvstGdaSieaaaknggItkia 54 
                 k+  ++  + ++ i+++ +ng+I +ia
  EFC36192.1  75 KNEVYIADYQNNRIRKILENGNIITIA 101
                 55567788899************9996 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.01
         TRL  31 LglvstGdaSieaaaknggItkia 54 
                  ++   G+ Si+++ +ng+I +ia
  EFC36192.1 134 VYIADSGNHSIRKILENGNIVTIA 157
                 566667**************9996 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.017
         TRL  32 glvstGdaSieaaaknggItkia 54 
                 ++  tG+  i+++ +ng+I +ia
  EFC36192.1 191 YIADTGNHRIRKILRNGNIITIA 213
                 67789**************9996 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.28
         TRL  28 ksiLglvstGdaSieaaaknggItkia 54 
                 k+  ++  + +  i+++ +ng+I +ia
  EFC36192.1 243 KNEVYIADYQNTRIRKILENGNIITIA 269
                 556678888999***********9996 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.32
         TRL  32 glvstGdaSieaaaknggItkia 54 
                 ++  + ++ i+++ +ng+I +ia
  EFC36192.1 303 YIADYQNNRIRKILENGNIITIA 325
                 666778999**********9996 PP

>> DUF5485  Family of unknown function (DUF5485)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.065   1.3e+02      28      44 ..       2      18 ..       1      20 [. 0.88
   2 ?    0.1   0.0       0.5   9.9e+02      28      42 ..      59      73 ..      57      78 .. 0.88
   3 ?   -1.5   0.0       1.7   3.3e+03      28      42 ..     227     241 ..     225     246 .. 0.85
   4 ?    3.4   0.0     0.047        94      28      41 ..     283     296 ..     280     302 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.065
     DUF5485 28 avdaklytPrfifcats 44
                a +a+l+ Pr if + s
  EFC36192.1  2 ATNAQLFNPRSIFVSSS 18
                679**********9887 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.5
     DUF5485 28 avdaklytPrfifca 42
                av+a+l  P ++f +
  EFC36192.1 59 AVNAQLVSPSYVFVS 73
                89***********86 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1.7
     DUF5485  28 avdaklytPrfifca 42 
                 av+akl  P  +f +
  EFC36192.1 227 AVNAKLSSPVDVFVS 241
                 8********988865 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.047
     DUF5485  28 avdaklytPrfifc 41 
                 av+akly P  +f 
  EFC36192.1 283 AVNAKLYSPVGVFV 296
                 8********98886 PP

>> NPH-II  RNA helicase NPH-II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.55   1.1e+03     120     148 ..      21      49 ..      12      67 .. 0.81
   2 ?    6.1   0.1    0.0047       9.4     110     149 ..      67     106 ..      49     123 .. 0.82
   3 ?   -1.3   0.0      0.88   1.8e+03     118     146 ..     131     159 ..     124     169 .. 0.82
   4 ?   -2.6   0.0       2.2   4.4e+03     119     146 ..     188     215 ..     182     224 .. 0.80
   5 ?    1.2   0.0      0.14   2.9e+02     113     146 ..     238     271 ..     217     293 .. 0.85
   6 ?    2.3   0.1      0.07   1.4e+02      97     143 ..     274     324 ..     237     337 .. 0.59

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.55
      NPH-II 120 gteiaeldeavlrGLvegGNklkiFsnsv 148
                 +  ia+ +++++r ++e GN + i  n +
  EFC36192.1  21 EVYIADTGNHTVRKILENGNIVTIAGNGQ 49 
                 456899999************99977655 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0047
      NPH-II 110 EcYsylkckkgteiaeldeavlrGLvegGNklkiFsnsvg 149
                  +Y ++ +k++  ia+ +++ +r ++e GN + i  n ++
  EFC36192.1  67 PSYVFVSSKNEVYIADYQNNRIRKILENGNIITIAGNGQQ 106
                 4799****************************99877655 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.88
      NPH-II 118 kkgteiaeldeavlrGLvegGNklkiFsn 146
                 k++  ia+ +++ +r ++e GN + i  n
  EFC36192.1 131 KNEVYIADSGNHSIRKILENGNIVTIAGN 159
                 566778999999**********9999766 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 2.2
      NPH-II 119 kgteiaeldeavlrGLvegGNklkiFsn 146
                  +  ia+ +++ +r ++  GN + i  n
  EFC36192.1 188 DEVYIADTGNHRIRKILRNGNIITIAGN 215
                 5667889999999********9999765 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.14
      NPH-II 113 sylkckkgteiaeldeavlrGLvegGNklkiFsn 146
                  ++ +k++  ia+ +++ +r ++e GN + i  n
  EFC36192.1 238 VFVSSKNEVYIADYQNTRIRKILENGNIITIAGN 271
                 6888999999******************999655 PP

  == domain 6  score: 2.3 bits;  conditional E-value: 0.07
      NPH-II  97 keyviedgtkisfEcYs....ylkckkgteiaeldeavlrGLvegGNklki 143
                   y  ++g ++    Ys    ++   ++  ia+ +++ +r ++e GN + i
  EFC36192.1 274 LGYGGDNGLAVNAKLYSpvgvFVSQDNEVYIADYQNNRIRKILENGNIITI 324
                 345566666666666664443444555556677777777777777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (727 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       645  (0.0359752); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.77u 0.31s 00:00:01.08 Elapsed: 00:00:00.48
# Mc/sec: 4513.01
//
Query:       EFC36193.1  [L=898]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.6e-31  107.9   0.0    1.6e-30  106.1   0.0    2.0  1  DEAD        DEAD/DEAH box helicase
    2.5e-21   76.1   2.5    3.8e-21   75.5   0.0    2.7  3  Helicase_C  Helicase conserved C-terminal domain
  ------ inclusion threshold ------
       0.02   15.3   0.4      0.064   13.7   0.4    1.8  1  MCR_alpha   Methyl-coenzyme M reductase alpha subunit, C-term


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  106.1   0.0   2.7e-34   1.6e-30       2     116 ..     404     523 ..     403     532 .. 0.94

  Alignments for each domain:
  == domain 1  score: 106.1 bits;  conditional E-value: 2.7e-34
                 HHHHHHHHHHHTTCEEEEEESTTSSHHHHHHHHHHHHHHHS...TTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHHTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   2 diQaeaiplilgggdvlvaaeTGsGKTlaflipvlqivyet...kgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskldng 97 
                 +iQ++a+p+i++g+++++ a+TGsGKTlaf++p+l++v+++   k+ +gp  ++++PtreLa q++++++kf  ++ l++ +++gg    +q++ l+ng
  EFC36193.1 404 AIQSQALPCIMSGRNIIGIAKTGSGKTLAFVLPMLRHVLDQpplKTVDGPIGIVMAPTRELAMQIHSDIEKFSAPLMLKTACVYGGAGIAEQIALLKNG 502
                 79************************************************************************************************* PP

                 CSEEEEEHHHHHHHH..HCTS CS
                 xxxxxxxxxxxxxxx..xxxx RF
        DEAD  98 vdivvgtpgrlddll..stgk 116
                 ++i+v tpgrl+dll  ++g+
  EFC36193.1 503 AHIIVCTPGRLIDLLcaNRGR 523
                 *************88665555 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       0.7   4.2e+03      41      60 ..     243     262 ..     209     291 .. 0.65
   2 !   75.5   0.0   6.4e-25   3.8e-21      40     111 .]     537     608 ..     492     608 .. 0.83
   3 ?   -2.7   0.0       1.2   7.4e+03      41      61 ..     769     789 ..     746     797 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.7
                 STEEEESTTSTHHHHHHHHH CS
  Helicase_C  41 ikvavlhgelpqnereeile 60 
                   +  +h+el+q+e+ + ++
  EFC36193.1 243 KYMSSIHSELKQSEKPKEID 262
                 33457888888888766554 PP

  == domain 2  score: 75.5 bits;  conditional E-value: 6.4e-25
                 TSTEEEESTTSTHHHHHHHHHHHHTTSSSEEEESGGGTSSSTSTTESEEEESSSSSSHHHHHHHHTTSSSTT CS
  Helicase_C  40 gikvavlhgelpqnereeileqfnkgesdvLiatdvaerGidipkvnlVinfdlprnvtsyiqriGRtgRag 111
                   +v++l+g+++q er+ ++++f+++++++++ t+v +rG+d+p+++lV+n+++p+ +++yi+ +GRtgRag
  EFC36193.1 537 RENVCTLDGSMEQIERDCTISDFKSQKFNIMVGTSVCSRGLDVPSIRLVVNYNCPDHYEDYIHKVGRTGRAG 608
                 6799******************************************************************97 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.2
                 STEEEESTTSTHHHHHHHHHH CS
  Helicase_C  41 ikvavlhgelpqnereeileq 61 
                   ++++h +++ +++e+ l+q
  EFC36193.1 769 AAALTVHTSISEKQKEKELSQ 789
                 567788999999999988877 PP

>> MCR_alpha  Methyl-coenzyme M reductase alpha subunit, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.4   1.1e-05     0.064      18     115 ..     696     792 ..     692     802 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.1e-05
   MCR_alpha  18 yataaytdnilddfvyygvdyvkdkygglakvkatlevvkdiatevtlyaleqyekyptlledhfGGsqraavlaaaagistalatgnsnaGlngwyl 115
                 ya +   d ild+     vd  k+k  + +k  ++ e+v d at+ +    +  ek  t+ e++    qra + aaa ++ t+++  + ++ l+   l
  EFC36193.1 696 YALTNNDDTILDQIDIQEVDETKKKDKSQKKKSKKEETVVDRATKAADAVYKDIEKDDTITEEEK-AIQRAQLFAAALTVHTSISEKQKEKELSQMIL 792
                 88889999******************999999999***********9999999999999999875.78****************99988888876655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (898 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2964  (0.165319); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.18u 0.31s 00:00:01.49 Elapsed: 00:00:00.53
# Mc/sec: 5098.87
//
Query:       EFC36194.1  [L=1196]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.7e-55  187.8  20.0    6.2e-55  186.7  20.0    1.6  1  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t
      4e-12   46.9   0.0    3.2e-08   34.1   0.0    3.1  2  Hydrolase        haloacid dehalogenase-like hydrolase
    4.5e-10   39.5   0.2    5.3e-09   36.1   0.1    2.7  2  Cation_ATPase    Cation transport ATPase (P-type)
    2.5e-09   36.9   0.1    2.6e-07   30.4   0.0    2.6  2  E1-E2_ATPase     E1-E2 ATPase
    0.00051   19.7   0.1    0.00051   19.7   0.1    3.2  3  PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
     0.0027   17.5   5.3     0.0077   16.0   0.1    3.3  3  Hydrolase_3      haloacid dehalogenase-like hydrolase


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  186.7  20.0   2.1e-58   6.2e-55       1     245 [.     900    1156 ..     900    1159 .. 0.97

  Alignments for each domain:
  == domain 1  score: 186.7 bits;  conditional E-value: 2.1e-58
  PhoLip_ATPase_C    1 vraSDyaiaqFrfLkrLLlvhGrwsyrRisklilyffyKnvvftlvqfwfqfyngfsgqslyeswlltlynllftslpvivlgifdqdvsae 92  
                       +r++D+a+++Fr++  LL+ hG+ sy+R+s + +++fyKnv++ l+q++f++++gfsg s+y++++l+lyn++ft + ++++ +fd + + +
       EFC36194.1  900 ARSADFAVGKFRHIIPLLFKHGHLSYHRTSMISQFSFYKNVLLALIQVLFNIFTGFSGISIYNELSLALYNFVFTGIFIFTY-VFDFNSRMD 990 
                       69***************************************************************************99988.********* PP

  PhoLip_ATPase_C   93 lllkyPelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvaletktwtliliili 184 
                        l  +P lYk++qk+k +n +tfl+wi  g++++ ii+ +++l+++d+++  +++ d  ++g++ +++++++  l ++ +++++++i++ +i
       EFC36194.1  991 DLITNPALYKSCQKSKSLNPRTFLTWIGIGFLHAGIILSFTWLAFNDNNSFIRQSIDKDYMGHVLYSSVLWTSVLSFLTYSNSFNIINMGVI 1082
                       ***********************************************9999***************************************** PP

  PhoLip_ATPase_C  185 lgsillyflflllyssllps.............ssefygvleelfsspsfwlvlllvvvvallpdllikvlkrt 245 
                       +++++ y+++l++y +   +              +++ygv+++++ +p+ +l++ll  v++++  l+i+ +++ 
       EFC36194.1 1083 IVTLIGYYCYLAVYGNAGAFlgitspilsavpgGKYTYGVFNQMMMDPTNYLIVLLNSVACWVSILAIRGIEKL 1156
                       ***********999998888889999999999999****************************99999988765 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.1   0.0   1.1e-11   3.2e-08       2     156 ..     381     743 ..     380     780 .. 0.87
   2 !    8.3   0.0   0.00085       2.6     174     209 ..     846     885 ..     826     886 .. 0.72

  Alignments for each domain:
  == domain 1  score: 34.1 bits;  conditional E-value: 1.1e-11
                 SEEEEESBTTTBCHHHHHHHHHHHHCHHHHHHHHHH.HHCHHHHHHHHHHHHH.HHHH.HHHHHETTTEHHHHTHHH.........HHHHH........ CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxx.xxxx.xxxxxxxxxxxxxxxxxx.........xxxxx........ RF
   Hydrolase   2 ktvvfDkdGTLttgepsvedvivsaalalaaaletg.sehpigkalvaaakar.sgal.tgfatfigrgayaigkpe.........wltal........ 80 
                 + ++ Dk+GTLt+ ++  +++ v+      ++  +  s     + +++  k + s +   +f +     +y    +          ++tal        
  EFC36194.1 381 NYILSDKTGTLTENRMIFKKCSVYG-----QVYDFDdSGNDAVRSFIRSVKTLhSYQQnNDFYE-----RYYLDDRSelrpflvtqFFTALslchtckr 469
                 78999**********9999999999.....4444446777777777777777764444477777.....666666665666655554444445455555 PP

                 ......HCHHHHHHHHHHHHHHCHHHHHH...................................................................... CS
                 ......xxxxxxxxxxxxxxxxxxxxxxx...................................................................... RF
   Hydrolase  81 ......dippdlgaaigsaqsqgrtvall...................................................................... 103
                        i+pd +  + ++q+ g +v+                                                                        
  EFC36194.1 470 egneykSISPDEECLVKACQTVGIEVYETqhdfyslkynlmdpnggstngsvtnsniqyntlinemnsarsgnksarsysynhtnsgnvsvsqiiplid 568
                 56677899999999999999999999999********************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
   Hydrolase 104 ................................................................................................... 103
                                                                                                                    
  EFC36194.1 569 saidsenntekydllhvfkftsdrkrmsvivrdvhtdkvilyckgaddmmlslmkndfcssdlnqtsknqinefsktglrtllvgfkyiepqeykifed 667
                 *************************************************************************************************** PP

                 .........................TTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHHTT CS
                 .........................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 104 .........................qaralavftiadplkvkpeaaeavasLkaagievvlltgdnpetaeraanqlG 156
                                          +  +l++ +i+d+  + + + +++++L++agi++++ltgd +eta+ +a  + 
  EFC36194.1 668 klrvvstlsegreaelsklysniesNLTYLGITAIEDE--LQEQVPQTIKKLRQAGINMWMLTGDKQETAQQIALSCQ 743
                 *************************99***********..*******************************9998766 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00085
                 TSHHHHHHHHHHHT....STGGGEEEEESSHHHHHHHHHT CS
                 xxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 174 pspegkvaaireLq....gkpeevamVGDgvnDaaalaaA 209
                  + +++++ +  L+     +    +++GDg nD++++++A
  EFC36194.1 846 REENMFKRFLHMLNlylfKRSVIALAIGDGQNDIPMIQKA 885
                 55667777777777666323333789***********998 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.1   0.1   1.8e-12   5.3e-09      45      86 ..     531     620 ..     462     624 .. 0.63
   2 ?   -1.6   0.0      0.97   2.9e+03      15      28 ..     723     736 ..     715     753 .. 0.83

  Alignments for each domain:
  == domain 1  score: 36.1 bits;  conditional E-value: 1.8e-12
  Cation_ATPase  45 e................................................tkkvqeipFnssrKrmsvvlklepekkvrlyvKGApeiilk 86 
                                                                     ++ +++++F+s+rKrmsv+++  ++ kv+ly+KGA +++l+
     EFC36194.1 531 LinemnsarsgnksarsysynhtnsgnvsvsqiiplidsaidsenntekYDLLHVFKFTSDRKRMSVIVRDVHTDKVILYCKGADDMMLS 620
                    0444444444555555555555555555555555555555555555444*************************************9986 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.97
  Cation_ATPase  15 devkllGnktEsAL 28 
                    + + l+G+k E+A 
     EFC36194.1 723 NMWMLTGDKQETAQ 736
                    67999*******95 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.4   0.0   8.5e-11   2.6e-07      11      64 ..      77     135 ..      68     176 .. 0.80
   2 ?    3.5   0.1     0.015        44      85     146 ..     242     319 ..     221     343 .. 0.71

  Alignments for each domain:
  == domain 1  score: 30.4 bits;  conditional E-value: 8.5e-11
                   -TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.....EEE-TTTS---S-EE- CS
  E1-E2_ATPase  11 rdgteeeidakelvpGDivllkagdrvpaDgrivegsa.....evdesaLTGEslpvek 64 
                   +d+ + +i++k++++GDi++l+++d +paD++++++ +      v+++ + GE     k
    EFC36194.1  77 QDDFLIKIKSKDIKVGDIIKLEENDEIPADCVLIQSANengisYVTTANMDGEVDLKLK 135
                   4566778****************************554333447888888888766555 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.015
                   EEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTT...................H CS
  E1-E2_ATPase  85 Vtatgedtelgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgksla...................e 146
                   V+ tg++t+ g   + ++++ +kk++   k+dk++  ++++ ++ia++  ++ +l +++l                     
    EFC36194.1 242 VVYTGNETKSGM--NKTKAP-NKKAQSDYKIDKMSIAIFFIQIAIAIIGGVLGILSNEKLLkgrswylaikegsildpfvV 319
                   556666665553..344444.78999999******************9999999988777667555555555444444444 PP

>> PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.1   1.7e-07   0.00051      42      67 .]       1      26 [.       1      26 [. 0.95
   2 ?   -1.0   0.3      0.48   1.4e+03      33      47 ..     849     863 ..     847     871 .. 0.83
   3 ?   -2.0   0.3         1   3.1e+03      33      51 ..     929     947 ..     920     961 .. 0.62

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 1.7e-07
  PhoLip_ATPase_N 42 aNlYFLviailqliPqisplspvtti 67
                     +N YFL ia+lql+ ++sp++p+tt+
       EFC36194.1  1 MNRYFLAIACLQLWSEVSPVNPITTW 26
                     599*********************96 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.48
  PhoLip_ATPase_N  33 nLfeqFrrvaNlYFL 47 
                      n+f+ F ++ NlY +
       EFC36194.1 849 NMFKRFLHMLNLYLF 863
                      89***********76 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1
  PhoLip_ATPase_N  33 nLfeqFrrvaNlYFLviai 51 
                      +++ qF+ + N+   +i +
       EFC36194.1 929 SMISQFSFYKNVLLALIQV 947
                      5678888888875533322 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.8      0.85   2.5e+03      82     150 ..      43     113 ..      36     127 .. 0.65
   2 ?    2.0   0.0     0.047   1.4e+02      15      53 ..     705     743 ..     700     763 .. 0.87
   3 !   16.0   0.1   2.6e-06    0.0077     207     228 ..     870     891 ..     855     907 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.85
                  HHHHHHHHHHHHTTCEEEEEESSEEEESTT...THHHHHHHHHCHCTCEEEESHHHHHCHCSESEEEEES- CS
  Hydrolase_3  82 edvkeiikllkennveillytedkvyvlnk..eksekkkkeeektkkkkeeidseeeledeeiakililkd 150
                  +d+k++++  k+n  ++ +++ +++ +++   +++++   ++++++ k+ +i + ee+++ ++  +li   
   EFC36194.1  43 DDLKRFYNDYKSNFKTFTVVNRKYLNTSSInnSRQDDFLIKIKSKDIKVGDIIKLEENDEIPADCVLIQSA 113
                  56666666666666666666655544444344677777777777777777777777777777777775544 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.047
                  ---HHHHHHHHHHHHTTSEEEEE-SS-HHHHHHHHHHCC CS
  Hydrolase_3  15 kisektkeaikklkekgikvviATGRslravlpvleelg 53 
                  +++e+  ++ikkl+++gi+    TG + +++++++ + +
   EFC36194.1 705 ELQEQVPQTIKKLRQAGINMWMLTGDKQETAQQIALSCQ 743
                  67889999*****************99999999887665 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 2.6e-06
                  EEEESSGGGHHHHHHSSEEEEE CS
  Hydrolase_3 207 iafGDgeNDieMLeaaglgvAm 228
                  +a+GDg+NDi+M+++a +gv +
   EFC36194.1 870 LAIGDGQNDIPMIQKAHVGVGI 891
                  79*************9888754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       955  (0.0532657); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.85u 0.33s 00:00:01.18 Elapsed: 00:00:00.50
# Mc/sec: 7136.96
//
Query:       EFC36195.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0042   16.5   4.5     0.0042   16.5   4.5    1.6  1  TMEM156   TMEM156 protein family
  ------ inclusion threshold ------
        5.4    4.0  20.1        6.7    3.7  20.1    1.0  1  GREB1     Gene regulated by oestrogen in breast cancer


Domain annotation for each model (and alignments):
>> TMEM156  TMEM156 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   4.5   4.7e-07    0.0042      76     197 ..      83     211 ..      73     212 .] 0.66

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 4.7e-07
     TMEM156  76 QeqtsKvlimkgSvevkaedfispckyfNft...vapavdeveeynttcllkthtrksa...vveeeaakekslnhtCrimeslnnCinisLqlemdvk 168
                 Q + +K ++ +  +  k+    ++ +++  +   v  a  +    ++t    t+t++s    +v + ++++ + n+  ++  ++ +C+ ++  +emd k
  EFC36195.1  83 QSSYEKSSKTTTTTTYKTTTRRTYRQHYEHSsssVQGASSSTATAAITSAALTSTANSPprlLVTHASSNNVTPNNNSSMRSENSECVDVFKSIEMDTK 181
                 55555555666666666665555555555541115555555666666777777777775222334444444556666677777889************* PP

     TMEM156 169 nvicsmkitWyvlvllvfi.fliiliihKi 197
                 +++  mk + y +   v+  fl  lii+ i
  EFC36195.1 182 YTTKKMKFILYLIYYYVYNyFLRYLIIFHI 211
                 ***********9999998614556888887 PP

>> GREB1  Gene regulated by oestrogen in breast cancer
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7  20.1   0.00075       6.7    1132    1287 ..      16     166 ..       2     175 .. 0.59

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.00075
       GREB1 1132 aadaaeessktspvkvekseskdavesglsskasakselseasaaaasaseea.kspkasvtseeeeseeskekekeslsketesqlsleaseqkea 1227
                   +++++++++++p++  +s ++ +++ ++      ++  ++++ + a+ ++ + +++++   +++++++++  +++ + s++t+++++ +++++++ 
  EFC36195.1   16 NNNNNSNNNQMVPTNSLNSPHTTTQHYTKY-----NNY-NNKNGQIATYRNVSvSNSYSGNPNNNTTTSTMAAQSSYEKSSKTTTTTTYKTTTRRTY 106 
                  222222222333333222222111111111.....111.1112222222222202222233344444555555666677777777777888889999 PP

       GREB1 1228 ldakasskssssssssssassPssscslakavkrPpivllskavydiltssdssglpkss 1287
                   +++++s+ss +++sss+a++  +s+ l+ ++++Pp +l+++a  + +t+++ s + +  
  EFC36195.1  107 RQHYEHSSSSVQGASSSTATAAITSAALTSTANSPPRLLVTHASSNNVTPNNNSSMRSEN 166 
                  99999999999999999999999999********************99999888776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2712  (0.151263); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.48
# Mc/sec: 1323.60
//
Query:       EFC36196.1  [L=439]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.018   14.6   0.6      0.018   14.6   0.6    2.2  3  Peptidase_M60  Peptidase M60, enhancin and enhancin-like
      0.078   13.4   0.9       0.28   11.7   0.6    2.0  2  FidL_like      FidL-like putative membrane protein


Domain annotation for each model (and alignments):
>> Peptidase_M60  Peptidase M60, enhancin and enhancin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.2      0.34     3e+03     211     231 ..     113     133 ..     112     147 .. 0.85
   2 ?   -0.4   0.0     0.074   6.6e+02      98     130 ..     174     205 ..     163     208 .. 0.82
   3 ?   14.6   0.6     2e-06     0.018     218     268 ..     226     285 ..     185     288 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.34
  Peptidase_M60 211 ffgqlklyfgwdfykklleaa 231
                    +f + k+ ++++fy+ l++++
     EFC36196.1 113 TFKNVKYGLNENFYHVLFYEF 133
                    799999********9999876 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.074
  Peptidase_M60  98 saGfahagypstafppssksellnvedlrksgW 130
                    s G  ++g+p+  ++ ++ ++++n+e +++ +W
     EFC36196.1 174 S-GGFYSGQPFSVHNLKILQHVTNYELNNQANW 205
                    3.45899***99999***********9977669 PP

  == domain 3  score: 14.6 bits;  conditional E-value: 2e-06
  Peptidase_M60 218 yf...........gwdfykklleaarkqetlteenkegdkqdefmkkasklakkdLtdFFek 268
                    ++           g  f +++++ a+k ++++ + ++    d++ +++sk+a+k+Lt  F+k
     EFC36196.1 226 WAgfmhymsirfgGLSFVQRIFKIAKKLTQQPLNPQQ--VLDNWFISCSKAAQKNLTLLFTK 285
                    2233444455556999****************99777..******************88865 PP

>> FidL_like  FidL-like putative membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.43   3.8e+03      29      46 ..     141     158 ..     124     168 .. 0.67
   2 ?   11.7   0.6   3.1e-05      0.28      20      81 ..     293     354 ..     273     357 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.43
   FidL_like  29 edtYrlsisqssissiDe 46 
                 ++  + + ++ ++s+iD+
  EFC36196.1 141 SNSLTCQETKCNSSFIDG 158
                 444455666667777765 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 3.1e-05
   FidL_like  20 YsskresadedtYrlsisqssissiDetpdvifdkflremsdskdslllevkklndntlLls 81 
                  s +++ ++e   +++ +q+++ss   ++  i ++ +++m +s+  + +e k+++ n +L++
  EFC36196.1 293 HSAIEQIQQEFRISYEYDQIEKSSNPHSQISITNQHVSSMNESNIPFNIEFKEYDANCILIG 354
                 444444455555567789******************************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (439 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2703.55
//
Query:       EFC36197.1  [L=196]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-05   24.9   2.7       0.29   12.1   0.0    3.5  2  WD40      WD domain, G-beta repeat


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   1.6e-05      0.29      24      38 .]       8      22 ..       3      22 .. 0.86
   2 !    8.0   1.8   0.00031       5.5       9      38 .]      35     106 ..      24     106 .. 0.55

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.6e-05
                EEEEEETTSEEEEEE CS
        WD40 24 wlasGsdDgtvriWd 38
                ++ sGs+Dgt+ +Wd
  EFC36197.1  8 LFYSGSYDGTIQLWD 22
                478***********9 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00031
                 SSSS.EEEEEEETTSSE................EEE.........................EETTSEEEEEE CS
        WD40   9 GHss.vtslafspdgaw................las.........................GsdDgtvriWd 38 
                  Hs+ v+sl+f  ++ +                l+s                         +s+Dg+v+i+d
  EFC36197.1  35 KHSGyVNSLCFYNNQIYstsidgisifdsnnlkLISkskqkseilsschlstgensshlyfSSKDGSVKIFD 106
                 4633588888666655544444444444444442224444444444566666666666666788*****998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       775  (0.0432261); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1114.69
//
Query:       EFC36198.1  [L=3715]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     1e-118  395.7   1.0     1e-118  395.7   1.0    2.5  2  Beach            Beige/BEACH domain
    6.9e-21   74.2   0.1    6.9e-21   74.2   0.1    3.8  5  PH_BEACH         PH domain associated with Beige/BEACH
     0.0098   16.7   1.5       0.27   12.2   0.2    3.9  3  WD40             WD domain, G-beta repeat
  ------ inclusion threshold ------
       0.29   11.5   2.4        1.7    9.0   0.5    2.8  2  Arc_trans_TRASH  Archaeal TRASH domain


Domain annotation for each model (and alignments):
>> Beach  Beige/BEACH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.3      0.63   2.8e+03      50     116 ..    1161    1230 ..    1150    1258 .. 0.70
   2 !  395.7   1.0  2.3e-122    1e-118       1     276 []    3201    3484 ..    3201    3484 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.63
       Beach   50 dektyRdLskpigalneerlekl..keryeelee.eepkflygshyssaaivlyylvRlePftelalelq 116 
                  ++k +R +s + + + ++r+e++  k+++++ ++   pk+ y+s  s+++ ++++ +R+e  ++ +++l 
  EFC36198.1 1161 KSKRLRLFSSSSSKMAHDREERIllKRTLNTFSSiLFPKMNYSSWPSEKGHTTTLWFRIESNSNSKISLF 1230
                  4556677777777777766555411444444433578999999999999999999999999888888775 PP

  == domain 2  score: 395.7 bits;  conditional E-value: 2.3e-122
       Beach    1 ekWqkgeisnfeYLmalNtlagRsfndlsqYpvfPwvlkdyeseeldledektyRdLskpigalneerleklkeryeelee..eepkflygshyssa 95  
                  +kW++g+isnfeYLm+lN+lagRsfndl+qYpvfP++l+dy+s+eldl+d++t+RdL+kp+galne+rlek++++ye+l++  ++ +++ygshys++
  EFC36198.1 3201 QKWVEGTISNFEYLMHLNILAGRSFNDLTQYPVFPFILRDYDSKELDLSDPNTFRDLKKPMGALNEKRLEKIIQQYENLKDveDQIPYHYGSHYSTP 3297
                  79****************************************************************************766668999********** PP

       Beach   96 aivlyylvRlePftelalelqsgkfdvadrlfksieeawesvt...esesdvkEliPeffylpefllnsnnldlglkqe.ekvddVeLPpwakkspe 188 
                    v yylvR+ePft++++e+++gk d +dr+f+s++++we+++   +s+sd+kEl+Peffylpefl+n+n++d+g+ q+ ++ ddVeLPpwa+++p 
  EFC36198.1 3298 IAVSYYLVRMEPFTRIFFEFNDGKLDLPDRTFHSLKKSWELSSgetQSKSDFKELTPEFFYLPEFLQNRNRIDFGILQNdKSFDDVELPPWANGDPV 3394
                  *****************************************99876799**************************99866***************** PP

       Beach  189 eFvrihreaLeseyvsenLheWIDliFGykqrgeeavkaknvfhpltyegev..dlekiedeeekkaieaqikefGqtPkqlfkkphpkr 276 
                   F+r+hr+aLes+yvs+nLh+WIDliFGykqrge+a++++nvfh++tyeg++  +++ i+d+++++a  +qi ++GqtPkqlfkk hp+r
  EFC36198.1 3395 LFIRKHRKALESDYVSRNLHHWIDLIFGYKQRGESAINSYNVFHYMTYEGSLtdEVDLIDDPITREARWTQICTYGQTPKQLFKKAHPER 3484
                  **************************************************8776888899****************************98 PP

>> PH_BEACH  PH domain associated with Beige/BEACH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1       3.1   1.4e+04      10      39 ..    2392    2421 ..    2389    2429 .. 0.54
   2 ?   -4.0   0.3       3.7   1.7e+04      17      47 ..    2511    2540 ..    2501    2547 .. 0.57
   3 ?   -4.1   0.2       3.9   1.7e+04      30      59 ..    2840    2869 ..    2826    2872 .. 0.74
   4 ?   -3.8   0.1       3.1   1.4e+04      34      61 ..    2986    3013 ..    2981    3013 .. 0.79
   5 !   74.2   0.1   1.5e-24   6.9e-21       1      98 [.    3061    3160 ..    3061    3162 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 3.1
    PH_BEACH   10 vkGklsittkelvFtadseeeeaseseees 39  
                  ++G l   +k+ +F+++s++ +++++ +++
  EFC36198.1 2392 LQGVLAFFQKNYLFHEKSKTLKKDKQLQKK 2421
                  567778888888887773322222222222 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 3.7
    PH_BEACH   17 ttkelvFtadseeeeaseseeeseltadkkk 47  
                  t+++++F++++ e+e  + ++es+ + ++++
  EFC36198.1 2511 TSTSMIFEKQHIEDESPTVQSESN-NTEDNP 2540
                  567889999844444444444443.333444 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 3.9
    PH_BEACH   30 eeaseseeeseltadkkkkdkewklseike 59  
                  +e+s+++++s+  ++ ++++ + +l++ik 
  EFC36198.1 2840 SEESDKKKDSNIRKNLRNEQTQLELNKIKY 2869
                  456778888888888888888888888875 PP

  == domain 4  score: -3.8 bits;  conditional E-value: 3.1
    PH_BEACH   34 eseeeseltadkkkkdkewklseikevh 61  
                   ++e++ ++ ++++k+++ k+sei+ vh
  EFC36198.1 2986 FQSETQLTNVQSSQKKRSVKFSEITTVH 3013
                  5666777788888999999999999997 PP

  == domain 5  score: 74.2 bits;  conditional E-value: 1.5e-24
    PH_BEACH    1 celvtpmkvvkGklsittkelvFtad..seeeeaseseeeseltadkkkkdkewklseikevhlrrYlLrktAlEiFladrtsllfnFeskkerrkv 95  
                  c+ +tp+++++G l + ++ ++F a      + +++s++++++++ + kk+ +++++ei+e+h+rrYlL+++AlE+Fl +++s++f+F++ ++r++v
  EFC36198.1 3061 CKRITPLRITEGDLILGEDGVYFIAScsYPLTIRTNSSSTNHSKQLEMKKTYNFSYEEIREIHNRRYLLKNNALEFFLLNGKSFFFAFDDGETRDRV 3157
                  99***********************98756667788889999999999***********************************************99 PP

    PH_BEACH   96 lka 98  
                  l+ 
  EFC36198.1 3158 LSI 3160
                  875 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.7   7.8e+03       7      21 ..    1420    1435 ..    1415    1441 .. 0.70
   2 ?    0.3   0.0      0.35   1.6e+03       3      29 ..    3585    3614 ..    3583    3632 .. 0.70
   3 !   12.2   0.2   5.9e-05      0.27       3      32 ..    3652    3682 ..    3650    3684 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.7
                  EESS.SSEEEEEEETT CS
        WD40    7 ltGH.ssvtslafspd 21  
                    GH  +vt+++ s++
  EFC36198.1 1420 VHGHnANVTAQSPSDE 1435
                  579*555****76554 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.35
                  EEEEEESS..SS..E.EEEEEETTSSEEEEEE CS
        WD40    3 clrtltGH..ss..v.tslafspdgawlasGs 29  
                  +l+++  H  +   +  + +fs++g++l+ G+
  EFC36198.1 3585 QLHIF--HfmNQpeIyKCAKFSREGDMLVVGT 3614
                  56664..5443358966777********9986 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 5.9e-05
                  EEEEEESS.SSEEEEEEETTSSEEEEEETTS CS
        WD40    3 clrtltGH.ssvtslafspdgawlasGsdDg 32  
                  ++ tl+GH +sv ++a s + ++++sGs+D 
  EFC36198.1 3652 HVATLSGHsDSVLCVAISTEFSMIISGSRDS 3682
                  6789****777*****************997 PP

>> Arc_trans_TRASH  Archaeal TRASH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.5   0.00039       1.7       6      24 ..    1494    1512 ..    1490    1521 .. 0.83
   2 ?    0.7   0.1      0.15   6.9e+02      12      36 ..    2751    2775 ..    2748    2776 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00039
  Arc_trans_TRASH    6 keivgePivyklknkvYyv 24  
                       +e+ +e  v+k knk+Yy+
       EFC36198.1 1494 NEMINEESVVKFKNKIYYM 1512
                       78999999**********7 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.15
  Arc_trans_TRASH   12 PivyklknkvYyvCCktCkselkkk 36  
                        i+ +l +kv+ v  +tCk  lkk+
       EFC36198.1 2751 TILPQLNRKVWKVIISTCKDYLKKN 2775
                       566788999999999********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (3715 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1592  (0.0887947); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.80u 0.30s 00:00:02.10 Elapsed: 00:00:00.57
# Mc/sec: 19726.24
//
Query:       EFC36199.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-35  122.3   0.5    4.3e-35  121.2   0.6    1.5  2  NAD_binding_2    NAD binding domain of 6-phosphogluconate deh
    2.9e-34  117.9   0.0    6.8e-34  116.7   0.0    1.6  2  NAD_binding_11   NAD-binding of NADP-dependent 3-hydroxyisobu
    1.3e-05   25.7   0.0    4.2e-05   24.1   0.0    1.9  2  F420_oxidored    NADP oxidoreductase coenzyme F420-dependent
    0.00088   20.1   0.0     0.0018   19.1   0.0    1.6  1  GFO_IDH_MocA     Oxidoreductase family, NAD-binding Rossmann 
     0.0033   16.8   0.0     0.0062   15.9   0.0    1.4  1  2-Hacid_dh_C     D-isomer specific 2-hydroxyacid dehydrogenas
     0.0041   16.6   0.6     0.0064   16.0   0.6    1.3  1  OAF              Transcriptional regulator, Out at first
  ------ inclusion threshold ------
      0.027   14.4   0.0      0.059   13.3   0.0    1.6  1  3HCDH_N          3-hydroxyacyl-CoA dehydrogenase, NAD binding
       0.12   12.2   0.1       0.24   11.3   0.1    1.5  1  Transketolase_C  Transketolase, C-terminal domain


Domain annotation for each model (and alignments):
>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  121.2   0.6   1.9e-38   4.3e-35       1     158 []      10     183 ..      10     183 .. 0.88
   2 ?   -3.1   0.0       3.4   7.5e+03      63      75 ..     284     296 ..     236     303 .. 0.64

  Alignments for each domain:
  == domain 1  score: 121.2 bits;  conditional E-value: 1.9e-38
                    EEEEE--SHHHHHHHHHHHHTT...-EEEEE-SSHHHHHHHHHTT..EEE-SSHHHHHHHC.SEEEE-SSSHHHHHHHHHS...HCCC-....-TT CS
  NAD_binding_2   1 kigfiGlGvMGsnmalnllkag...ykvavynrtkekveelvaeg..akaaesieelvasl.dvvitmvkagkavdevieg...lleal....kkg 83 
                    +igfiGlG+MG+ ma nllka+   y+v +y++  +++e   +++  ++a++si +++++  d+vitm++ +k v +v+++   l++++    k  
     EFC36199.1  10 RIGFIGLGQMGARMAPNLLKADsnaYEVFAYDVMDSNIEMTTKKQskINACKSIDQIMQQNpDCVITMLPTTKIVTQVYDEvvsLKKKYgaseKIR 105
                    59****************765433399*************9999778************999*******************665555557776778 PP

                    -EEEE-S---HHHHHHHHHHHHHTT..-EEEEEEEESHHHHHHHT-EEEEEEE-HH.HHHHH.HHHHHHHEEEEEEE-E CS
  NAD_binding_2  84 dilidgstsspedtrelakelkekg..lkfldaPVSGGeegAekGtLsimvGGsee.aferv.kpvleaigakvthviG 158
                    +++id+st++p++ +++++ +k+++  ++++daPVSGG++gAe++tL++mvG++++ +fe + k++l+++g++++ + G
     EFC36199.1 106 TVCIDSSTVDPKTVQDIEQLIKREQlnMSVMDAPVSGGVNGAENATLTFMVGTDNKvDFEFAqKNILSKMGKSIVLC-G 183
                    9*******************9988844678***********************998578866256*******99966.5 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.4
                    SSSHHHHHHHHHS CS
  NAD_binding_2  63 vkagkavdevieg 75 
                    +  g++v+e++++
     EFC36199.1 284 LAMGQHVQELYKQ 296
                    4445555555555 PP

>> NAD_binding_11  NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       4.1   9.1e+03      93     106 ..      79      92 ..      74     112 .. 0.61
   2 !  116.7   0.0   3.1e-37   6.8e-34       1     121 [.     187     313 ..     187     314 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.1
  NAD_binding_11  93 pllalaeqlyaaaa 106
                     p ++ ++q+y ++ 
      EFC36199.1  79 PTTKIVTQVYDEVV 92 
                     55666666665442 PP

  == domain 2  score: 116.7 bits;  conditional E-value: 3.1e-37
  NAD_binding_11   1 GaGqavKlvnnlllainlaaasEalvlaekaGldpekvlevinassgrsnalenk......lpqrvlsrdfdpgFaldlmlKDlglalelareag 89 
                     G Gq++Kl+nnl+l+i++a +sEalvl++k+G+dp+++ ++  +s++++++++ +      +++ + sr+++ gFa++lmlKDlgl++++a++ +
      EFC36199.1 187 GMGQVAKLCNNLVLGISMAGVSEALVLGTKLGMDPKVLSQIFGTSTAQCWSVTAYnpfpgvMENVPSSRNYEGGFAVNLMLKDLGLVNSAAKNID 281
                     89*************************************************7666666666999999**************************** PP

  NAD_binding_11  90 aplpllalaeqlyaaaaaegggdaDhsaivrl 121
                     ++l +++++++ly++a+++g g++D+ ai+++
      EFC36199.1 282 YDLAMGQHVQELYKQASEHGLGGKDFGAILKY 313
                     *****************************997 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0   1.9e-08   4.2e-05       1      76 [.      10      85 ..      10     100 .. 0.80
   2 ?   -3.0   0.0       5.1   1.1e+04      62      81 ..     208     227 ..     202     234 .. 0.78

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.9e-08
                   EEEEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHH.HHHC-EEECECHHHHHHH-SEEEE-S-HHHHHH CS
  F420_oxidored  1 kigiiGaGnmgealasgllaagaqpheivvansrnpekaeela.eelgvkvtavdneeaaeeadvvvlavkpedvee 76
                   +ig+iG G+mg+ +a +ll+a+ +++e+  a + + + +e +  ++ +++++++  + + ++ d v+  ++++++  
     EFC36199.1 10 RIGFIGLGQMGARMAPNLLKADSNAYEVF-AYDVMDSNIEMTTkKQSKINACKSIDQIMQQNPDCVITMLPTTKIVT 85
                   79***************************.889999988877624555999996777777799***99999877644 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 5.1
                    -SEEEE-S-HHHHHHHHHHC CS
  F420_oxidored  62 advvvlavkpedveevlsel 81 
                    ++ +vl  k  + ++vls++
     EFC36199.1 208 SEALVLGTKLGMDPKVLSQI 227
                    67889999999999999988 PP

>> GFO_IDH_MocA  Oxidoreductase family, NAD-binding Rossmann fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0     8e-07    0.0018       1      74 [.       9      82 ..       9     135 .. 0.90

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 8e-07
                  EEEEEETTSHHHHHHHHHHHHTTTTEEEEEEECSSHHHHHHH.HHHTTHEEESSHHHHHTCTTESEEEE-S-GGG CS
  GFO_IDH_MocA  1 lrvaiiGaGkigskhlrplnesqrleevvalldpdaeraeav.aesfgveaysdleelladpeidavivatpngt 74
                  lr+++iG+G++g + +++l ++++++  v ++d   ++ e    ++ +++a+++++++++ +++d+vi + p+++
    EFC36199.1  9 LRIGFIGLGQMGARMAPNLLKADSNAYEVFAYDVMDSNIEMTtKKQSKINACKSIDQIMQ-QNPDCVITMLPTTK 82
                  69************************888899999999998879999*************.66*****9999854 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   2.8e-06    0.0062      35     106 ..       7      85 ..       1      97 [. 0.77

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 2.8e-06
                   TTSEEEEES-SHHHHHHHHHHHHTT-...EEEEESSSHHHHH..CHHHHTC.EECSHHHHHHH.-SEEEE-S--STTTT CS
  2-Hacid_dh_C  35 sgktvGiiGlGrIGqavakrlkafgm...kviaydrskkkee..eeeelgv.elvsleellae.sDivslhlpltpetr 106
                   ++ ++G iGlG++G ++a  l + +    +v+ayd+  ++ e  ++++ ++  + s+++++++  D+v+ +lp t+  +
    EFC36199.1   7 EKLRIGFIGLGQMGARMAPNLLKADSnayEVFAYDVMDSNIEmtTKKQSKInACKSIDQIMQQnPDCVITMLPTTKIVT 85 
                   5679**************877655433349*******999888755555554667****9986269******9998655 PP

>> OAF  Transcriptional regulator, Out at first
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.6   2.8e-06    0.0064      78     164 ..      53     139 ..      43     161 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 2.8e-06
         OAF  78 eknefissdamaklrqknpktvRsaeekkgteeltldvavnvsksallskhiknlCaeakdavytreeDvkkwleregsalelleka 164
                 +++ + + +++ ++ q+np+ v +   +    + + d +v ++k    s++i+++C ++ +      +D++++++re+ +++++++ 
  EFC36199.1  53 KQSKINACKSIDQIMQQNPDCVITMLPTTKIVTQVYDEVVSLKKKYGASEKIRTVCIDSSTVDPKTVQDIEQLIKREQLNMSVMDAP 139
                 5566778899***************9999999***************************99999999*********99999988775 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   2.6e-05     0.059       2      71 ..      11      82 ..      10      93 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.6e-05
                EEEE--SCCHHHHHHHHHHT...T-EEEEE-S-HHHHHHHHHHHHHHHHCCTTTTSS-HHHHCCCHHCEEEES CS
     3HCDH_N  2 vaviGaGtmGagiaavfasa...gleVvlvdiseealekalekieksleklvekgklkeeeveaalarisftt 71
                ++ iG G+mGa +a  +++a    +eV  +d+ ++ +e  ++k +k ++  ++  ++ +++ + +++ + +t+
  EFC36199.1 11 IGFIGLGQMGARMAPNLLKAdsnAYEVFAYDVMDSNIEMTTKKQSK-INACKSIDQIMQQNPDCVITMLPTTK 82
                789***********999987445699*********99999988776.77777777787777777777666555 PP

>> Transketolase_C  Transketolase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   0.00011      0.24      34      84 ..      97     152 ..      65     163 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00011
                      T.....TTCEEEEE-SEEESHHHHHHHHHHHHHSEEEEEEEEESTTSHHHHHHHHH CS
  Transketolase_C  34 e.....gisaeVvdlrtvkplDketilesvkktgrlvvveeavkrgGigsevaaal 84 
                      +     +i++ ++d  tv+p   ++i++++k+ +  + v +a ++gG+  + +a+l
       EFC36199.1  97 KygaseKIRTVCIDSSTVDPKTVQDIEQLIKREQLNMSVMDAPVSGGVNGAENATL 152
                      4444449****************************************987766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       843  (0.0470188); expected 358.6 (0.02)
Passed bias filter:                      559  (0.0311785); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1923.10
//
Query:       EFC36200.1  [L=711]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     5e-125  418.2  44.8   5.4e-120  401.6  40.4    2.0  2  STT3      Oligosaccharyl transferase STT3 subunit
  ------ inclusion threshold ------
      0.067   13.2   0.8       0.73    9.9   0.1    2.8  2  CrgA      Cell division protein CrgA


Domain annotation for each model (and alignments):
>> STT3  Oligosaccharyl transferase STT3 subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  401.6  40.4    6e-124  5.4e-120       2     488 .]      17     496 ..      16     496 .. 0.95
   2 !   18.9   0.1   6.7e-08    0.0006     448     485 ..     517     555 ..     508     557 .. 0.93

  Alignments for each domain:
  == domain 1  score: 401.6 bits;  conditional E-value: 6e-124
                 HHHHHHHHHCCCCCHCC.CCCCCCT--S--SSCHHHHHHHCCCHHHT-C.....CCHHSSEETTSSTTT-EEESTTCCHCCC.CHHHHHHCCHHC.... CS
        STT3   2 lilvifalialvavasrdlFtdedglsylsefDpYYnyRltenllnnGfpGdvvikkknwfdhsqyyPpGsrvdygplivlLamlasaiinhsld.... 96 
                 l ++i+a+i ++a+  r lF++++++s+++efDpY+n+R  ++l++nG+     +++ nwfd++++yP G rv +g++++++  +++a+++++l+    
  EFC36200.1  17 LRIAILAAIYVLAFCVR-LFSVFRYESVIHEFDPYFNFRSAKYLVENGW-----YDFYNWFDDFSWYPIG-RVVGGTVYPGI-QITAAFMYWILRainf 107
                 6678999**********.*******************************.....****************.***********.**************** PP

                 .HHHHHHHHCCHHHHHHHHCHHHHHHHHHHS-CCCHHHHHHHCCC-CCCCCTTSTT--STCCCCHHHHHHHHHHHHHHHHCCSTTCHHHHHHHHHHHHH CS
        STT3  97 .vsirevclwlpallgsLlaIpiyflvrelksdiaGllAAlllaiaPgYlsrtvaGfyDtdmfeivlllfvlffflkaiktksnkislaviaaliifli 194
                  v++r+vc++ +++++s +a+++y +++e+ ++ a+l++ +l+a++PgY+sr+vaG++D+++ +i++l+ ++++f+k++ t+s   +++++a l++f++
  EFC36200.1 108 tVDLRNVCVLTSPFFASNTAMITYAFTNEISGPSAALVSSILVALVPGYISRSVAGSFDNEGVAIFALICTFYLFVKSVRTGS--LFWSAVACLSYFYM 204
                 ***********************************************************************************..************** PP

                 HTTSCCGGHHHHCCHHHHHHHHHCTTTS-CCHHHHHHHHHHHHHHH..CCCCCCCTTCHHHSTTTCHHCCCCHHHHHHHHCCCHHC..CCCCCHHCCCH CS
        STT3 195 vlaWggyailiyallllfilalLiigrfelklkiavtfsviiaflviaiivllflgfqvvavseiigalgifgllqlvafgsvvvlvaelkfyqfislf 293
                 v aWggy ++i++l+++++l+lL++grf+++l++a+  ++i+++l+  ++++ f++fq v++se++ga+g+f llqlv f++  ++   l+ + f+ lf
  EFC36200.1 205 VNAWGGY-VFIINLIPVYVLVLLVTGRFSHRLYVAYSSFYILGTLL--SMQVRFVNFQAVQTSEHLGAMGVFILLQLVNFVNWIRS--LLDAKMFQRLF 298
                 *******.**************************************..**************************************..99********* PP

                 HTT.HHHHTT--GGGHHHHHHHHHHHHCCCCCCTS-----TTHHHHHHHHHS---S--CCHHHCCSSSTTTTCCCHHHCHHCCHHCTCHHHHHHHHHHH CS
        STT3 294 qpgilsevlgligevvtalavlglialwlgilyslldleyaklkikiiilvsvwlpvgllaltkglrfliftvPlgiifvgllleflavfvkiysvsqi 392
                  +  +s ++ ++g +  + +++g+ia+w+g++y +ld  yak +i+ii++vs+++p+++++++++l++l +++P+g++f++ +l  + +f+++y + ++
  EFC36200.1 299 GFV-VSSFVLTAGLAILIGSATGYIAPWTGRFYAMLDPTYAKKHIPIIASVSEHQPTTWASFFFDLHILALLFPVGLYFCFRELTEASIFIIMYGMFSV 396
                 *99.99999999*************************************************************************************** PP

                 HHCCC-SCHCCCCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHH.....HHHHCT.TTTTHHHTTHHHCHHHHHHHHHHHHHHHHHHHHHHHHHC CS
        STT3 393 lfsgvvvillmltllpvlallaavkiskifstykdekeakikvaakav.....aptksnglkeslewkantnrdsvvitwwdyghilaveadrpVtfdg 486
                 +f+gv+v+ l+l+l+p+ ++l+++ isk+++ty+ + +ak    +         ++ks   ++  ++   ++  +++++++ +++ ++v++ ++Vt+++
  EFC36200.1 397 YFAGVMVR-LILVLAPAACVLSGIGISKTLKTYMRALKAKTPKQETTTtasqdPKKKSSTPEKPSQNPLPKEIAAIMVIAMTFLLTFYVIHCVWVTSEA 494
                 ********.***************************9999987443334344322222223333333456677899*********************** PP

                 CS CS
        STT3 487 gs 488
                 +s
  EFC36200.1 495 YS 496
                 98 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 6.7e-08
                 TTTTHHH.TTHHHCHHHHHHHHHHHHHHHHHHHHHHHHH CS
        STT3 448 lkeslew.kantnrdsvvitwwdyghilaveadrpVtfd 485
                   e+ +w  +nt+ d+ v++wwdyg+ l+++a+r V++d
  EFC36200.1 517 FREAYYWlSENTKPDAKVMSWWDYGYQLTAMANRTVLVD 555
                 578999*******************************99 PP

>> CrgA  Cell division protein CrgA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1     0.085   7.6e+02      26      56 ..     348     378 ..     334     408 .. 0.76
   2 ?    9.9   0.1   8.1e-05      0.73       4      55 ..     434     485 ..     429     494 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.085
        CrgA  26 aakpsprwyvpvmlglmllGllwlvvyYlag 56 
                  ++ +p+ ++  ++ l +l ll+ v  Y+  
  EFC36200.1 348 VSEHQPTTWASFFFDLHILALLFPVGLYFCF 378
                 56788999999999****9999988877655 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 8.1e-05
        CrgA   4 skvrkkaeytpkaaertpvkakaakpsprwyvpvmlglmllGllwlvvyYla 55 
                 +k+ k++++t+++++ ++++++ +kps++ +   + ++m++ + +l+++Y+ 
  EFC36200.1 434 AKTPKQETTTTASQDPKKKSSTPEKPSQNPLPKEIAAIMVIAMTFLLTFYVI 485
                 3333433333335555555566688999999999999999999999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (711 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       919  (0.0512577); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.31s 00:00:01.05 Elapsed: 00:00:00.49
# Mc/sec: 4353.20
//
Query:       EFC36201.1  [L=603]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-05   25.2   0.1    3.9e-05   23.4   0.1    2.0  1  F-box           F-box domain
  ------ inclusion threshold ------
       0.23   11.7   3.5        0.4   11.0   0.1    2.8  3  DUF1430         Protein of unknown function (DUF1430)


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.1   4.3e-09   3.9e-05       2      40 ..      93     131 ..      92     136 .. 0.91

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 4.3e-09
                 HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTH CS
       F-box   2 tlsrLPsevlrhILerLplsdllalrrVSkgwrilidsd 40 
                 tl +L+++ ++ I+e+L+  d++ +++ Skg+r+l+  +
  EFC36201.1  93 TLMDLCNDEILLIFEYLSNFDVFKMSQLSKGFRDLVEQV 131
                 6789*******************************9765 PP

>> DUF1430  Protein of unknown function (DUF1430)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.7      0.33     3e+03       6      24 ..     141     159 ..     133     176 .. 0.74
   2 ?   -1.5   0.1      0.33     3e+03       6      25 ..     165     184 ..     160     188 .. 0.77
   3 ?   11.0   0.1   4.4e-05       0.4      21      75 ..     439     493 ..     427     518 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.33
     DUF1430   6 lslllivqlvllYFeqfkk 24 
                  s+ li +++  YF++ +k
  EFC36201.1 141 RSSTLIHFMNSRYFYNIQK 159
                 4567888888888876544 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.33
     DUF1430   6 lslllivqlvllYFeqfkkk 25 
                 ++  +i q+vl+Y + ++ k
  EFC36201.1 165 TIPHIIAQSVLTYCNSNRLK 184
                 44578999999999999976 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 4.4e-05
     DUF1430  21 qfkkkilikkihGyslfkrhkeyliiqlivllillvlifiltkekiillvvlvll 75 
                 ++  ++++  i G s+++ +++++++++i+++  l l++ + ++++i+l    +l
  EFC36201.1 439 RNLTELVLHTIDGGSTMEGYQSFFTSKNISNIKKLSLVCPWDSQDLIFLANTTVL 493
                 588999*************************************999988766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (603 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1383  (0.0771376); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 3718.45
//
Query:       EFC36202.1  [L=373]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-11   41.4   0.3       0.46   10.7   0.0    7.0  8  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
      0.017   15.5   3.3       0.94   10.0   0.0    4.3  5  LRR_4     Leucine Rich repeats (2 copies)
      0.054   13.3   0.0        0.2   11.5   0.0    1.8  2  DUF724    Protein of unknown function (DUF724)
       0.12   12.6   1.0       0.91    9.8   0.2    2.7  3  YjcQ      YjcQ protein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.35   1.6e+03       3      14 ..     111     122 ..     111     122 .. 0.88
   2 ?   -1.1   0.0      0.61   2.8e+03      15      21 ..     154     160 ..     147     163 .. 0.83
   3 !    7.3   0.0    0.0012       5.4       4      24 .]     170     190 ..     169     190 .. 0.92
   4 ?    2.7   0.0     0.037   1.7e+02       9      23 ..     200     214 ..     197     215 .. 0.80
   5 ?   -0.3   0.0      0.33   1.5e+03       4      24 .]     222     242 ..     221     242 .. 0.82
   6 !   10.7   0.0    0.0001      0.46       4      24 .]     249     269 ..     246     269 .. 0.91
   7 !    9.7   0.0    0.0002      0.92       3      24 .]     275     296 ..     273     296 .. 0.92
   8 ?   -1.9   0.0       1.1   4.8e+03       3      13 ..     302     312 ..     300     319 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.35
       LRR_6   3 thLteLdLsgNd 14 
                 t+L++L + +++
  EFC36202.1 111 TKLKKLRMGCCG 122
                 68*******995 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.61
       LRR_6  15 IgDeGae 21 
                 +gDeG++
  EFC36202.1 154 MGDEGIK 160
                 79***87 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0012
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L+L +++I+ eG + La
  EFC36202.1 170 NLTKLSLWFCNITLEGFKMLA 190
                 7***************88886 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.037
       LRR_6   9 dLsgNdIgDeGaeaL 23 
                  L++ ++gDeG + +
  EFC36202.1 200 KLTCTELGDEGFKYF 214
                 58999******6655 PP

  == domain 5  score: -0.3 bits;  conditional E-value: 0.33
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 ++++L++    +++ G++ +a
  EFC36202.1 222 NIEYLNVGLGSLSNLGMQYFA 242
                 7899***99999999988765 PP

  == domain 6  score: 10.7 bits;  conditional E-value: 0.0001
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 ++++L L +Nd++ eG+++++
  EFC36202.1 249 KVKTLLLDSNDFTAEGVKSIC 269
                 689999*************98 PP

  == domain 7  score: 9.7 bits;  conditional E-value: 0.0002
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 +++++L++ +  IgD+G++ La
  EFC36202.1 275 QSVEYLEMEYSPIGDDGVKYLA 296
                 6899***************997 PP

  == domain 8  score: -1.9 bits;  conditional E-value: 1.1
       LRR_6   3 thLteLdLsgN 13 
                 ++L+ L +++ 
  EFC36202.1 302 RNLKCLGIAST 312
                 78999998875 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0     0.075   3.4e+02      19      33 ..     108     120 ..      88     136 .. 0.73
   2 ?   10.0   0.0   0.00021      0.94       1      30 [.     169     203 ..     159     212 .. 0.77
   3 ?    0.2   0.2      0.26   1.2e+03      22      42 ..     220     236 ..     214     262 .. 0.65
   4 ?   -1.5   0.0      0.89     4e+03       2      30 ..     249     282 ..     248     289 .. 0.50
   5 ?   -3.1   0.0       2.7   1.2e+04      21      29 ..     300     308 ..     295     314 .. 0.66

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.075
                 HHH-TT--EEE-.-S CS
       LRR_4  19 leklpnLkeLdLsgN 33 
                   ++++Lk+L + g+
  EFC36202.1 108 S-SFTKLKKLRM-GC 120
                 3.4999999998.43 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00021
                 SS--EEE--SS---E-S-HH......H-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqltdiplle......klpnLkeLdL 30 
                 +nL++L+L  +++t +++++      k+ +L +L++
  EFC36202.1 169 KNLTKLSLWFCNIT-LEGFKmlasnsKFSKLVKLTC 203
                 68999999999999.778555556655777777776 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.26
                 -TT--EEE-.-S-----GGGG CS
       LRR_4  22 lpnLkeLdLsgNnlitdldeL 42 
                 + n ++L++ g   +++l++L
  EFC36202.1 220 FSNIEYLNV-G---LGSLSNL 236
                 556666665.3...4444443 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 0.89
                 S--EEE--SS-.....--E-S-HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNq.....ltdiplleklpnLkeLdL 30 
                 + ++L L +N      +++i    ++ + ++L +
  EFC36202.1 249 KVKTLLLDSNDftaegVKSICQSDNIQSVEYLEM 282
                 5667777776622222333333335666666666 PP

  == domain 5  score: -3.1 bits;  conditional E-value: 2.7
                 H-TT--EEE CS
       LRR_4  21 klpnLkeLd 29 
                 k+ nLk L 
  EFC36202.1 300 KMRNLKCLG 308
                 377887775 PP

>> DUF724  Protein of unknown function (DUF724)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.35   1.6e+03      68     100 ..     169     201 ..     152     207 .. 0.75
   2 ?   11.5   0.0   4.4e-05       0.2      18      66 ..     209     258 ..     204     270 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.35
      DUF724  68 seleslkeslaeLekhGFdVkalqsrlnkLlsl 100
                 + l +l+  ++++  +GF   a  s+ +kL++l
  EFC36202.1 169 KNLTKLSLWFCNITLEGFKMLASNSKFSKLVKL 201
                 566667777777888888888888888888776 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 4.4e-05
      DUF724  18 evFkkvPQrPHFspLleakeelREgsAlGlmv.sfagllekvkklsidds 66 
                 e Fk + Q+PHFs ++  +  l   s lG+ +   +  l+kvk l +d +
  EFC36202.1 209 EGFKYFCQSPHFSNIEYLNVGLGSLSNLGMQYfASSPYLKKVKTLLLDSN 258
                 89***************************964134457888888887765 PP

>> YjcQ  YjcQ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.2    0.0002      0.91      49      89 ..     158     201 ..     110     205 .. 0.73
   2 ?   -2.8   0.0       1.7   7.8e+03      73      89 ..     237     253 ..     233     260 .. 0.79
   3 ?    0.1   0.0      0.21   9.4e+02      55      83 ..     273     301 ..     250     313 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.0002
                 --EESSS......SEE--SS--EE-HHHHHHHHHHT-S---XXX CS
        YjcQ  49 Gvkvkktkk...geivisidnvritlkGleyLkeNsmmkKalka 89 
                 G+k++   +   +   +s+   +itl+G + L++Ns  +K +k+
  EFC36202.1 158 GIKIIAEGTkfkNLTKLSLWFCNITLEGFKMLASNSKFSKLVKL 201
                 44444443333244556666689*****************9986 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.7
                 HHHHHHHHT-S---XXX CS
        YjcQ  73 GleyLkeNsmmkKalka 89 
                 G++y ++   +kK++ +
  EFC36202.1 237 GMQYFASSPYLKKVKTL 253
                 89999999999998766 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.21
                 S...SEE--SS--EE-HHHHHHHHHHT-S CS
        YjcQ  55 tkkgeivisidnvritlkGleyLkeNsmm 83 
                  +++   + ++ + i  +G++yL+e   m
  EFC36202.1 273 NIQSVEYLEMEYSPIGDDGVKYLAESPKM 301
                 44445556677778899999999997666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (373 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       467  (0.0260472); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 2259.04
//
Query:       EFC36203.1  [L=215]
Description: GCN5-related N-acetyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-11   44.2   0.2      5e-11   42.9   0.2    1.7  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    1.3e-08   34.9   0.4      3e-08   33.7   0.4    1.8  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    1.6e-06   28.4   0.5      5e-06   26.9   0.4    2.0  3  Acetyltransf_7   Acetyltransferase (GNAT) domain
     0.0013   18.8   0.0     0.0027   17.8   0.0    1.5  1  Acetyltransf_CG  GCN5-related N-acetyl-transferase
  ------ inclusion threshold ------
      0.082   13.1   0.2      0.095   12.9   0.2    1.1  1  DUF4586          Domain of unknown function (DUF4586)
      0.099   12.3   0.0        1.2    8.7   0.0    2.0  2  FAD-oxidase_C    FAD linked oxidases, C-terminal domain
       0.11   12.4   0.0        9.6    6.2   0.0    2.6  2  TPR_10           Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.9   0.2     2e-14     5e-11      55     117 .]     120     191 ..      73     191 .. 0.80

  Alignments for each domain:
  == domain 1  score: 42.9 bits;  conditional E-value: 2e-14
                     T......TSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHT..TE.SEEEEEEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  55 d......ekggvayieslaVspeyrgkGlGsaLlealeeraree..gi.kkivlaveedndaairlYeklGF 117
                     +      ++++++++++++V +e++g  ++ +L++++++ aree  g+ k i+l v e+n +a r+Yek+ F
      EFC36203.1 120 FepclkyQNKETIELCRCYVLKEFHGTSIAHKLMQECLRVAREEfgGVcKSIWLGVWEHNLRAKRFYEKFKF 191
                     35555566799**********************************8778999*****************977 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.7   0.4   1.2e-11     3e-08      47     112 ..     125     197 ..      22     203 .. 0.79

  Alignments for each domain:
  == domain 1  score: 33.7 bits;  conditional E-value: 1.2e-11
  Acetyltransf_10  47 elrdgs..hisllfVdpeyrgqGigkaLleaveeeaekdgikl....eltvnasp.yavpfYeklGFkavgee 112
                      ++++++  ++++++V +e++g+ i+++L++++++ a+++ +++     l v +++  a++fYek+ F++vge 
       EFC36203.1 125 KYQNKEtiELCRCYVLKEFHGTSIAHKLMQECLRVAREEFGGVcksiWLGVWEHNlRAKRFYEKFKFEKVGEH 197
                      3333336799*****************************99988645578999999*************9874 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       4.9   1.2e+04      64      72 ..      25      34 ..      12      35 .. 0.59
   2 ?   -1.9   0.0       1.9   4.8e+03      59      72 ..      93     104 ..      76     105 .. 0.61
   3 !   26.9   0.4   1.9e-09     5e-06      25      76 .]     132     193 ..      96     193 .. 0.69

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 4.9
                    HHHH.HHHHT CS
  Acetyltransf_7 64 kaik.fYekl 72
                     a   fYe +
      EFC36203.1 25 VAKTlFYEAF 34
                    3333599876 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.9
                     EETHHHHHHHHHHT CS
  Acetyltransf_7  59 elnaekaikfYekl 72 
                      l+   + +fYe++
      EFC36203.1  93 FLD--SNMSFYESN 104
                     342..357899985 PP

  == domain 3  score: 26.9 bits;  conditional E-value: 1.9e-09
                     TCTEEEEE-GGGTTSSHHHHHHHH......TTSE..EE.EE.EEEETHHHHHHHHHHTTEEE CS
  Acetyltransf_7  25 aeitrlaVdpeyrgkGiGraLlea......aekg..ii.le.qlelnaekaikfYeklGFee 76 
                      e++r +V++e++g  i+++L++       +e g  ++ ++  ++ ++ +a +fYek+ Fe+
      EFC36203.1 132 IELCRCYVLKEFHGTSIAHKLMQEclrvarEEFGgvCKsIWlGVWEHNLRAKRFYEKFKFEK 193
                     456669****************96566654224444443233344455599*******9985 PP

>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   1.1e-06    0.0027      15      56 ..     124     163 ..     106     166 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.1e-06
  Acetyltransf_CG  15 leYevrkegvldfthTeVpeelrGkGiAkkLvkaalddaree 56 
                      l+Y+  +++++++   +V +e+ G  iA kL++++l  aree
       EFC36203.1 124 LKYQ--NKETIELCRCYVLKEFHGTSIAHKLMQECLRVAREE 163
                      6786..6669*****************************986 PP

>> DUF4586  Domain of unknown function (DUF4586)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.2   3.7e-05     0.095     152     260 ..       5     128 ..       2     154 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.7e-05
     DUF4586 152 gvtlgksyeyssdey.........drekklekkereekhkkklkGkpFkstlvpkdyfdenpYke......dkplppgkkeatkekevkapkaepakef 235
                 ++t+ k+    +d+            ++++++  + e++ +  ++++F +t   k+  d+n Y +      d+ l+++ k+++ ++++     + + +f
  EFC36203.1   5 NITIRKPSLTTEDDVslltsvaktLFYEAFHQD-NTEENMRDYLEQAFNTTQQVKELTDPNVYLSfiqvdyDNALEEYLKQKCTPERIE--FLDSNMSF 100
                 555555555555555555544432223444444.556699999**********************999999999998888888888886..4466777* PP

     DUF4586 236 kpsspakklg...ggkaGtfnpFPeysa 260
                 ++s++ k +    + + G f+p  +y++
  EFC36203.1 101 YESNQKKLVIaysKLNYGSFEPCLKYQN 128
                 ****888555888888888888666665 PP

>> FAD-oxidase_C  FAD linked oxidases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0     0.077     2e+02     223     245 ..      45      67 ..      36      69 .. 0.78
   2 ?    8.7   0.0   0.00049       1.2      21      94 ..      77     166 ..      73     183 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.077
                    ----THHHHHHHHHHHH-TT--B CS
  FAD-oxidase_C 223 ekgeeglalmrriKaalDPkgiL 245
                     + e+++++ +++K++ DP+ +L
     EFC36203.1  45 DYLEQAFNTTQQVKELTDPNVYL 67 
                    455779999**********9877 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00049
                    HHHHHHHHT---SEEEEE-HHHHHHHHHTS-SS...................TTS-TTT-EEEEEEEEE-HHHHHHHHHHHHHHHTTT-EEEE CS
  FAD-oxidase_C  21 avreiaqagiipaalelmdkkaldlveatkgak...................kglpdeeealllvefegddeeeaeeelealveaileatgaa 94 
                    a+ e  ++++ p ++e++d++++    ++k+ +                   k   + + +++l ef+g++   a++ ++ ++ + +++++++
     EFC36203.1  77 ALEEYLKQKCTPERIEFLDSNMSFYESNQKKLViaysklnygsfepclkyqnKETIELCRCYVLKEFHGTS--IAHKLMQ-ECLRVAREEFGG 166
                    677888999***********99888888888889999999***********9999***************9..6666666.777666666555 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.032        82      22      37 ..      44      59 ..      34      64 .. 0.78
   2 ?    6.2   0.0    0.0037       9.6      21      37 ..     149     165 ..     147     167 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.032
      TPR_10 22 ealleealairrrllG 37
                +++le+a ++ +++ +
  EFC36203.1 44 RDYLEQAFNTTQQVKE 59
                457**********987 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0037
      TPR_10  21 AealleealairrrllG 37 
                 A +l++e+l++ r+ +G
  EFC36203.1 149 AHKLMQECLRVAREEFG 165
                 899***********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       825  (0.0460148); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1313.50
//
Query:       EFC36204.1  [L=677]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.8e-30  106.0   0.1    2.9e-29  102.1   0.1    2.6  2  TLD           TLD
  ------ inclusion threshold ------
      0.041   14.1   1.0       0.13   12.5   1.0    1.8  1  ThuA          Trehalose utilisation
       0.67    9.3  11.6      0.047   13.1   6.1    1.8  2  U79_P34       HSV U79 / HCMV P34
        2.6    8.3   9.6        1.7    8.9   0.2    2.9  3  Flu_M1_C      Influenza Matrix protein (M1) C-terminal domain


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.1     5e+03       7      38 ..     338     369 ..     336     413 .. 0.58
   2 !  102.1   0.1   6.4e-33   2.9e-29       1     138 [.     490     656 ..     490     657 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.1
         TLD   7 kdgsslstllekienkgptlllikdekkyifG 38 
                 ++gs+++ ++e++++++p +   +++ k+++ 
  EFC36204.1 338 RSGSNAQPFVEELDDRSPPISPNNSSPKQTVS 369
                 67888888888888776655544333333333 PP

  == domain 2  score: 102.1 bits;  conditional E-value: 6.4e-33
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnk.kfygdsesflfsl..............................spkfk 68 
                 llys++++g sl tl++k+ +++p++++++++++ +fGafl+++++ +++ k+ygd+esf+f++                              +p+++
  EFC36204.1 490 LLYSTQEHGISLLTLYRKVAENQPIIIVVETTHGEVFGAFLTCEIELTKRdKYYGDAESFVFKFdkqkeeeekeepedhedfvlvehplkdnkpQPTIH 588
                 79*******************************************5555557*********************************************** PP

         TLD  69 vykstgknkaylntssdglgfGggqpkfsLwidsslekgtsrhsetfengllsgaseerfkikdiEVWgl 138
                  yk+ ++n++++++s + l++Ggg ++f++++d++l+ g+s++set++n++l+  s+++f+i+ +E ++l
  EFC36204.1 589 AYKWMKTNEYFQLSSAKQLAVGGGGDGFAFTLDADLKYGSSHKSETYGNDPLT--STTDFEIYSVEAFTL 656
                 *****************************************************..9***********987 PP

>> ThuA  Trehalose utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   1.0   2.8e-05      0.13      97     160 ..      15      79 ..       5      94 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.8e-05
                 HHH.HH-SEEEEE.T............TSGGGTT--.SEEEEEEEEE-S---SE...EEEEE.... CS
                 xxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxx RF
        ThuA  97 wfsgLiGarfvgh.ppvqeatvkvedrshpateglpeewertdewYnfkpnprg.vhvlatvdest 160
                  +++LiG++ v++ +++qe   +v+ ++h a++ ++ + e+ d + + k+np++ +++  t++ + 
  EFC36204.1  15 QYGDLIGTDVVSNaNKQQEISENVNSHHHDANQIIN-NTEIVDDQRQNKSNPNNtTNTTTTTTSTA 79 
                 4666*******995467778888**9*********7.77777666666677777444444443333 PP

>> U79_P34  HSV U79 / HCMV P34
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   6.1     1e-05     0.047     136     195 ..     150     213 ..     133     241 .. 0.72
   2 ?   -3.1   0.2      0.87   3.9e+03     182     196 ..     554     568 ..     545     574 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1e-05
     U79_P34 136 dskcveklekegraldrkkaddeqrkrsgkqkekrkvedidkkkedekrkeeerkksde......d 195
                 + +++++l++ ++ + ++++  eqr r  ++  k ++  + k+ ede+rk+eerkk++e      +
  EFC36204.1 150 EYSLLDRLDGGTKVKIKNEKHFEQRIR--REERKSQIYTLMKQLEDEERKQEERKKKEEserlalQ 213
                 556777777777766655555556655..57778889999**************999984444441 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.87
     U79_P34 182 ekrkeeerkksdedk 196
                 +k+keee k + ed+
  EFC36204.1 554 DKQKEEEEKEEPEDH 568
                 455555555555555 PP

>> Flu_M1_C  Influenza Matrix protein (M1) C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.2   0.00038       1.7      27      68 ..      72     113 ..      59     117 .. 0.82
   2 ?    4.6   0.8    0.0083        37      16      71 ..     175     233 ..     168     241 .. 0.78
   3 ?   -3.5   0.2       2.8   1.3e+04      39      61 ..     287     309 ..     271     323 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00038
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Flu_M1_C  27 ttakameqmagssekaeevqklaeelrqnvqvlrslGasqks 68 
                 tt+ +   +  +++k ee  +l e  r+ +q +r lG +++s
  EFC36204.1  72 TTTTTSTAVNNNNNKIEEEEELNETTRDIIQKIRKLGEEPSS 113
                 444555556666799***********************9987 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0083
                 XXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Flu_M1_C  16 vrrenrmvlasttakameqmagsse...kaeevqklaeelrqnvqvlrslGasqksseG 71 
                 +rre r     t  k +e+     e   k ee  +la +++ +  vl+ +G   ++s  
  EFC36204.1 175 IRREERKSQIYTLMKQLEDEERKQEerkKKEESERLALQIQSQQAVLQEIGRRSRASSN 233
                 89999988888888888876544332228899*******************98776654 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 2.8
                 XXXXXXXXXXXXXXXXXXXXXXX CS
    Flu_M1_C  39 sekaeevqklaeelrqnvqvlrs 61 
                 s  a  v  +a+ + + v+++ s
  EFC36204.1 287 SGMATGVGTVASGVSNGVGTVAS 309
                 45566677777777777776544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (677 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3069  (0.171175); expected 358.6 (0.02)
Passed bias filter:                      713  (0.039768); expected 358.6 (0.02)
Passed Vit filter:                        84  (0.00468515); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.94u 0.30s 00:00:01.24 Elapsed: 00:00:00.50
# Mc/sec: 4107.10
//
Query:       EFC36205.1  [L=379]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-37  128.3   0.0    3.5e-37  127.2   0.0    1.6  1  TrmO      tRNA-methyltransferase O
    1.6e-05   24.9   0.0    3.7e-05   23.8   0.0    1.6  1  TrmO_C    TrmO C-terminal domain


Domain annotation for each model (and alignments):
>> TrmO  tRNA-methyltransferase O
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  127.2   0.0   3.9e-41   3.5e-37       1     119 []      35     182 ..      35     182 .. 0.87

  Alignments for each domain:
  == domain 1  score: 127.2 bits;  conditional E-value: 3.9e-41
                 TS-SSGGG--.-EEEEEE-...HHH..HGGGTTGGG-SEEEEEEE-TTS.........................-....SS--E-TT-.SS-E.EGGGS CS
        TrmO   1 giPrqpglaeeaeaeiele...peynseealegleefshlwllfvfhen......................aekkl...kakvrpprlggnervGvfat 71 
                 g+Prq+ ++++a++++ l+    + n+++ +egle+fsh+wl++vfh+n                              kakvrppr++g +++G +++
  EFC36205.1  35 GCPRQSLIVPKARGRLLLKfggFTSNTQHFVEGLEGFSHIWLFWVFHQNnnlaapndendnaassgteltkF---QmmqKAKVRPPRMNG-KKIGSLSC 129
                 79**************9986554567899******************8889999988777666555544331...03349*********9.899***** PP

                 --S-SSS-EEEEEEEEEEEE.....TTEEEEES----TT-EEEEEEE--HHHH CS
        TrmO  72 RsphRpnpiglsvvklekve.....gnvlevsgvDlldgtpvlDiKPYvpyaD 119
                 R+p+Rpnp+g+svvkl+++e     + +l++sg+Dl+dgtp++DiKPY+p++D
  EFC36205.1 130 RAPYRPNPLGMSVVKLDRIErdennNAILHLSGIDLVDGTPIVDIKPYIPEYD 182
                 ********************99997799***********************99 PP

>> TrmO_C  TrmO C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.0   4.1e-09   3.7e-05       4      64 ..     259     325 ..     256     326 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 4.1e-09
      TrmO_C   4 eVeFseeaeaqlqql...qksa.....pdlkqlIeevLaqDPRPaYkkskpeeriYgmrLydlnirwrv 64 
                 +V+F+e+ ++ +++l   +  +     +++k+l e+++++DPR  Y+++k +e  +g++   +ni  rv
  EFC36205.1 259 QVKFTERSLEMIETLlkkS--TfyktvDEVKSLFEDLIKLDPRSKYRREKCQEELFGIHVDVFNILCRV 325
                 89******99999996431..2344447*************************************8887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (379 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1484  (0.0827709); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2327.52
//
Query:       EFC36206.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
        2.9    8.3   7.5       0.31   11.4   2.0    2.1  2  DUF2924      Protein of unknown function (DUF2924)


Domain annotation for each model (and alignments):
>> DUF2924  Protein of unknown function (DUF2924)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.3       0.1   1.8e+03      11      48 ..      59      98 ..      49     122 .. 0.61
   2 ?   11.4   2.0   1.8e-05      0.31       5      78 ..     130     206 ..     126     228 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.1
     DUF2924 11 svkeLkekwrelfgeeapk..lnkeflekrlayriqelae 48
                  ++L+  + +  +ee ++  ++++f +++l   +  +  
  EFC36206.1 59 YYEDLRMSYIQERREEIRSklHERRFQRQQLEQSLLLDMP 98
                5566666666666666555556666666666655544444 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 1.8e-05
     DUF2924   5 aaLkelsvkeLkekwrelfgeeapklnkeflekrlayriqelaeggLseearrrleelaee....kekkkkkakkkke 78 
                 +aLk+++ ++L+ ++++ f e    +nk++l +r  +r + ++++ L++++r+ +ee   +    ++kk+++++kk+e
  EFC36206.1 130 EALKTTKRNTLNPEYDQAFCEY-LYNNKDVLLSRHLHRDRDRQFRTLQQTKRTIMEEDIGTpfikQKKKQDQERKKQE 206
                 799****************976.66788888888889*****************999988877643333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2174  (0.121256); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1539.80
//
Query:       EFC36207.1  [L=227]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-43  147.5   0.1    2.5e-43  147.1   0.1    1.1  1  UQ_con    Ubiquitin-conjugating enzyme
  ------ inclusion threshold ------
       0.15   12.3   3.4       0.53   10.6   3.4    2.1  1  RWD       RWD domain


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  147.1   0.1   2.8e-47   2.5e-43       3     137 ..      11     157 ..       9     160 .. 0.96

  Alignments for each domain:
  == domain 1  score: 147.1 bits;  conditional E-value: 2.8e-47
                 HHHHHHHHHSTTTTEEEEEEETTEECEEEEEEEB.TTSTTTTEEEEEEEE--TTTTTS--EEEESST-SCTTBETTSBB-CGGGS............TT CS
      UQ_con   3 qkelkelakkkpsgisaklvddenlfewkvlikgpedtpYeggvFklelefpedYPlkpPkvkfvtkifHPnvdksGevcldiLk............ee 89 
                  ++lk+++k++ +g++++l+d++++++w++ ikgp+dtp+e+g++  +++fpedYP++pP ++fv++++HPnv+++G+vc++iL+            ee
  EFC36207.1  11 INQLKKMQKEPVEGFTVELIDESDVYKWRFFIKGPSDTPFENGIYVGTIDFPEDYPFSPPVLTFVSEFWHPNVYTDGKVCISILHppgedemsgerpEE 109
                 578999*****************************************************************************************9999 PP

                 T--TTSHHHHHHHHHHHHHHS--TTS-SSHHHHHHHHHTHHHHHHHHH CS
      UQ_con  90 kWspaltlesvllsiqsLlaepnpesplnkeaakllkkdreeykkkvk 137
                 +W+p++t e++lls++s+l++pn +sp+n++a  +++++++ + ++ k
  EFC36207.1 110 RWNPTQTPETILLSVISMLSDPNFSSPANVDASVEWRNNKKGFLDRCK 157
                 9****************************************9988876 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   3.4     6e-05      0.53      58      78 ..      58      78 ..      13     226 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 6e-05
                EEEE-SSTTSS--EEEEEECC CS
                xxxxxxxxxxxxxxxxxxxxx RF
         RWD 58 eiklpeeYPeeaPiislsste 78
                +i++pe+YP ++P++++ s+ 
  EFC36207.1 58 TIDFPEDYPFSPPVLTFVSEF 78
                79*************998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       524  (0.0292264); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.32s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1437.51
//
Query:       EFC36208.1  [L=143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.075   13.1   2.3       0.12   12.6   1.7    1.6  1  CbtB      Probable cobalt transporter subunit (CbtB)


Domain annotation for each model (and alignments):
>> CbtB  Probable cobalt transporter subunit (CbtB)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   1.7   6.4e-06      0.12      14      42 ..      84     112 ..      75     117 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6.4e-06
        CbtB  14 vaAllLGlllvylvgfsqaaalHnaaHDt 42 
                 +  l+LG++   ++ f++a+a+H+a H++
  EFC36208.1  84 IIDLFLGVGFGHFLTFDPAKAAHDADHNF 112
                 556789999999***************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       320  (0.0178482); expected 358.6 (0.02)
Passed bias filter:                      221  (0.0123264); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 876.48
//
Query:       EFC36209.1  [L=130]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      0.001   19.0   4.2     0.0012   18.7   4.2    1.1  1  FA_desaturase  Fatty acid desaturase


Domain annotation for each model (and alignments):
>> FA_desaturase  Fatty acid desaturase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   4.2   6.8e-08    0.0012     135     236 ..       3     108 ..       1     117 [. 0.64

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 6.8e-08
  FA_desaturase 135 wrllawlllllawlglwlalllllglalllwlvplllllfllalvlnyveHyggdwgerqvetsasir.......saswllnlltgnlnyHieHHl 223
                    w +  ++  ++++++l++++l  +++  l+ lv+++l+++++ +v++ + H    w +  v   + +            l ++ +++ n H +HH+
     EFC36209.1   3 WKYAPMY--FARLVLLLAPFLIMNPIDYLMHLVMCRLVMTVIFMVFTTLAHEE-GWFDSMVDKFYPFQkyvdinlVLEILIGYHVHHVNEHDNHHI 95 
                    4445555..5555************9999555555555555555557777775.455555555555555550004455555555556678889*** PP

  FA_desaturase 224 fPgvpwyrLpelh 236
                    fP+   + L +++
     EFC36209.1  96 FPKRDVSMLEQIS 108
                    **99988888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       880  (0.0490825); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 818.36
//
Query:       EFC36210.1  [L=270]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.069   13.3   1.1        5.7    7.1   0.7    2.2  2  DUF5125   Domain of unknown function (DUF5125)


Domain annotation for each model (and alignments):
>> DUF5125  Domain of unknown function (DUF5125)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0    0.0018        33       6      26 ..      51      72 ..      47      81 .. 0.82
   2 ?    7.1   0.7   0.00032       5.7      57     104 ..     188     235 ..     155     251 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0018
     DUF5125  6 rPkpa.yltlleegkeyrmeks 26
                 Pkp+  lt+ ++gkey m k 
  EFC36210.1 51 SPKPSlILTVCKNGKEYSMRKR 72
                68888358999********986 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.00032
     DUF5125  57 vtlGyddsakgiaaestsaiPfanseaGeytitfnllaleasPfakll 104
                 v    + s+  i+  s++  P++++ +   t +f+ l+  +sP+++  
  EFC36210.1 188 VQTSSEVSTPVIPLTSSTITPYSSTTTCSITSQFDSLSSPSSPLSSCH 235
                 5555667787899999**9************************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1138  (0.0634726); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1734.44
//
Query:       EFC36211.1  [L=574]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.6e-27   94.3   2.2    1.7e-26   93.2   2.2    1.5  1  Pkinase         Protein kinase domain
    4.6e-23   80.7   2.7    1.3e-08   34.4   0.0    4.4  3  DUF4116         Domain of unknown function (DUF4116)
    4.7e-19   68.7   0.1      1e-18   67.6   0.1    1.5  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0017   18.3   0.0      0.048   13.6   0.0    2.2  2  APH             Phosphotransferase enzyme family
      0.006   15.4   0.0      0.024   13.4   0.0    2.0  2  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.026   13.9   0.0       0.06   12.7   0.0    1.6  1  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.2   2.2   5.7e-30   1.7e-26      22     234 ..      92     315 ..      81     331 .. 0.78

  Alignments for each domain:
  == domain 1  score: 93.2 bits;  conditional E-value: 5.7e-30
                 TTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.....CTTB--EEEEEEE....SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHH CS
     Pkinase  22 etgkivAvKkikkekakkkkekkvlrEikilkklk.....hpnivrlyevfee....kdelylvleyveggeladllerkgslseeeakkiakqilegl 111
                 e  k+++vK+ ++e ++++k  +++rE+++l k++     hpniv++y+  +     ++  y  + y + g+l+++++  +  +e+ ++ i+ q+++++
  EFC36211.1  92 EVVKKYVVKVYREEFNSSNK--SFMREVRYLLKFDgtifrHPNIVKVYYGETLkindDNFNYYKMKYYKFGSLDHWIN--KFNDEKILQLIMLQLVNSV 186
                 67789999999999998877..5**********9888999*******9754434443777789**************8..58899999*********** PP

                 HHHHHTTEE-SS-SGGGEEEET..TTE...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHH CS
     Pkinase 112 eylHskgiiHrDlKpeNiLide..kge...lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkek 205
                  ++ s++iiHrD+ p+N++ide  +++   + ++DF  a++ + ss+++++++  + +APEv   ++ys ++D +s+G++l+el+tgk  f++ + ++ 
  EFC36211.1 187 FFIQSHEIIHRDIRPANVFIDEfiDNKfpvIVLADFECATKSNFSSRKETEIIGAKLCAPEVF-MEGYSFESDNYSIGLTLFELITGKCNFQDFDVEK- 283
                 *********************744333799********************************9.99**************************443333. PP

                 HHHHHHTHHHHHHHCT...SHH...HHHTTS- CS
     Pkinase 206 vekeldqlekilkilg...etkeklpeaseis 234
                  ++e++  +++++i+    + k +    +e+ 
  EFC36211.1 284 LSSEYNLSKEFAEIVLgllKLKTERLSLDEVI 315
                 33333332233332222223333333333444 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.1   6.7e-08    0.0002       8      44 ..     352     388 ..     350     392 .. 0.91
   2 !   22.1   0.1   3.1e-08   9.2e-05      11      49 .]     404     442 ..     395     442 .. 0.88
   3 !   34.4   0.0   4.3e-12   1.3e-08       7      49 .]     449     491 ..     448     491 .. 0.96

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 6.7e-08
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 +++++  +++++se+ k+D ++  +A+k+ng ++ ++
  EFC36211.1 352 VIEQDFRNFQFISEKSKHDNDFKREALKRNGLIYQFF 388
                 68888889**************************997 PP

  == domain 2  score: 22.1 bits;  conditional E-value: 3.1e-08
     DUF4116  11 kngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +n +al++++e ++ D++++++  ++ + al+y++++++
  EFC36211.1 404 NNYKALEFAPEQIRGDIDLMKEFTESEPLALEYIPNSIK 442
                 6788*******************************9886 PP

  == domain 3  score: 34.4 bits;  conditional E-value: 4.3e-12
     DUF4116   7 eavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 e+vkkng+al+y+s+  +n++eiv++Av qn +al++a  ++r
  EFC36211.1 449 EIVKKNGLALQYASHIDQNNFEIVKRAVLQNAKALRFATTDIR 491
                 89************************************99887 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.6   0.1   3.4e-22     1e-18      24     217 ..      90     287 ..      69     297 .. 0.81

  Alignments for each domain:
  == domain 1  score: 67.6 bits;  conditional E-value: 3.4e-22
                  TTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHT....S.-BTTB--EEEEEE....SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHH CS
  Pkinase_Tyr  24 kekkevkVavKtlkeeateeekeelleeakimkk....l.khpnivkllgvct....keepllivteyvkgGdLlkfLrkkekekltlkdllsfalqv 112
                    +   k +vK+ +ee +++ ++++++e++ + k    + +hpnivk++   t    +++  +  ++y k G+L++ ++k ++     k l  ++lq+
   EFC36211.1  90 IIEVVKKYVVKVYREEFNSS-NKSFMREVRYLLKfdgtIfRHPNIVKVYYGETlkinDDNFNYYKMKYYKFGSLDHWINKFND----EKILQLIMLQL 182
                  555567789****9999998.89********9873333347******98766656644445999**************99833....33455678999 PP

                  HHHHHHHHHTTEEEST-SGGGEEEEE.....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGT CS
  Pkinase_Tyr 113 AkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgesp 205
                   + + +++s++++Hrd++  Nv+++e       v+ ++Df  a +    +  ++ke++ +  k +apE+++e+ ++ +sD +s G +l+E++t g+  
   EFC36211.1 183 VNSVFFIQSHEIIHRDIRPANVFIDEfidnkFPVIVLADFECATKS---NFSSRKETEIIGAKLCAPEVFMEG-YSFESDNYSIGLTLFELIT-GKCN 275
                  *************************98885556999****999987...66677888999********99875.9******************.**99 PP

                  TTTSHHHHHHHH CS
  Pkinase_Tyr 206 ypglkneevlek 217
                  +++++ e++ + 
   EFC36211.1 276 FQDFDVEKLSSE 287
                  999988887655 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.047   1.4e+02      14      60 ..      88     139 ..      79     157 .. 0.79
   2 !   13.6   0.0   1.6e-05     0.048     167     199 ..     193     228 ..     179     231 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.047
                 EEEEETT--EEEEEE-TT..S-HHHHHHHHHHHHHHHHTT-...B--B-CTT CS
         APH  14 ylvttpagryvlrrnppa..raaeeirrevallrlLakagv...pvPevlag 60 
                 y++ +  ++yv+++++++   +  ++ rev++l  + ++ +    + +v++g
  EFC36211.1  88 YKIIEVVKKYVVKVYREEfnSSNKSFMREVRYLLKFDGTIFrhpNIVKVYYG 139
                 555555579*********9999999999999999888874465555566655 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 1.6e-05
                 EEE-SS-SGGGEEEC.....TTEEEEE---TT-EEE CS
         APH 167 vllHgDlhpgNllvd...pddgrvtGviDfedaglg 199
                  ++H+D++p N+ +d   +++ +v+ + Dfe+a+ +
  EFC36211.1 193 EIIHRDIRPANVFIDefiDNKFPVIVLADFECATKS 228
                 589*********************9999*****976 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.0   7.9e-06     0.024     325     371 ..     191     237 ..     166     283 .. 0.86
   2 ?   -1.8   0.0      0.34     1e+03      94     119 ..     291     316 ..     277     339 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 7.9e-06
  Pkinase_fungal 325 kagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesga 371
                       +i+HrDi   N+ i +  +++ +  +L+D++ a++ +  s+++ +
      EFC36211.1 191 SHEIIHRDIRPANVFIDEFIDNKFPVIVLADFECATKSNFSSRKETE 237
                     578**************99999*****************87766643 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.34
  Pkinase_fungal  94 pekfirvvlglllmdddeLGlDptiv 119
                     +++f ++vlgll ++ ++L lD+ i+
      EFC36211.1 291 SKEFAEIVLGLLKLKTERLSLDEVIK 316
                     68999****************99885 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0     2e-05      0.06     141     267 ..     171     292 ..     161     320 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2e-05
  Kinase-like 141 letiarlllTlqlirlaanLqakglvhgkftvdnlllde....kggl.mlggftaLvragtkvvlseve...kgfaPpEllgsrggytrknktkmthk 230
                   e+i +l++ lql++ +  +q++ ++h ++++ n++ de    k+++ +l +f+   +   + +  e+e   + +  pE++ +           ++++
   EFC36211.1 171 DEKILQLIM-LQLVNSVFFIQSHEIIHRDIRPANVFIDEfidnKFPViVLADFECATKSNFSSR-KETEiigAKLCAPEVFME----------GYSFE 256
                  566666666.************************987543333999735799999999888888.555555677888888887..........46777 PP

  Kinase-like 231 ldaWqlGlviyriwclklPltl.ateeakeewkfklck 267
                   d + +Gl+ + +   k  ++  + e+ ++e  ++l k
   EFC36211.1 257 SDNYSIGLTLFELITGKCNFQDfDVEKLSSE--YNLSK 292
                  7777777777777666666544134444444..44444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (574 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       706  (0.0393775); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 3170.19
//
Query:       EFC36212.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.7e-28   97.3   1.0    1.1e-27   97.1   0.1    1.5  2  COesterase       Carboxylesterase family
  ------ inclusion threshold ------
      0.014   15.5   0.4      0.018   15.1   0.4    1.1  1  Peptidase_S49_N  Peptidase family S49 N-terminal
      0.034   15.1   1.8      0.067   14.2   1.8    1.4  1  DUF4834          Domain of unknown function (DUF4834)
      0.085   12.0   3.9       0.11   11.6   3.9    1.1  1  AI-2E_transport  AI-2E family transporter
      0.091   13.2   1.9       0.17   12.3   1.9    1.4  1  SIT              SHP2-interacting transmembrane adaptor prote
       0.13   12.7   0.3       0.18   12.1   0.3    1.3  1  Calc_CGRP_IAPP   Calcitonin / CGRP / IAPP family
       0.27   11.2   3.4        0.4   10.6   3.4    1.2  1  DUF4446          Protein of unknown function (DUF4446)


Domain annotation for each model (and alignments):
>> COesterase  Carboxylesterase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.42   1.1e+03     373     381 ..      68      76 ..      27     100 .. 0.42
   2 !   97.1   0.1   4.4e-31   1.1e-27       9     116 ..     103     210 ..      94     212 .] 0.88

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.42
                 CHHHHHHHH CS
  COesterase 373 daeksrkal 381
                 ++++  ++ 
  EFC36212.1  68 NHQQQHNEQ 76 
                 111111111 PP

  == domain 2  score: 97.1 bits;  conditional E-value: 4.4e-31
                 TEEEEEEEEEESTCSEEEEEEEEESSB---GGGTTS--BE.----SSEEECBS---BESEECSSSSSCGHHCHHHBES---EEEEEEESSS.....SST CS
  COesterase   9 lGkvrGkrvklksekevdaFlGiPYAepPvgelRFkkPep.aepwtgvrdAtkfspaCpqnaeksekeekeleawvsEDCLyLnvytPkek.....kea 101
                 lG++rG +  ++   ++++F+ iPYA++P+gelR++ P+p + p+ +++d+t+f+p+Cpqn+      + ++   +sEDCL Ln++tP +      +++
  EFC36212.1 103 LGTLRGVQSFID---NYKSFKTIPYAKAPIGELRWSDPQPqPLPFVDILDTTQFGPMCPQNCLLPHGLCAQN---QSEDCLSLNIFTPFNIsttttNSS 195
                 599999999976...79***********************999*******************8777766554...9***********987788886777 PP

                 TSSEEEEEEE--STT CS
  COesterase 102 kkklPVlVwihGggf 116
                 ++  PV+V++ Gg f
  EFC36212.1 196 NNLKPVMVFFPGGHF 210
                 7777*********99 PP

>> Peptidase_S49_N  Peptidase family S49 N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.4   7.2e-06     0.018      17     105 ..      13     102 ..       4     115 .. 0.56

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 7.2e-06
  Peptidase_S49_N  17 vvailvvvvlivalaakkkkekgelevtkLneeykelkeeleealld.eeelkaaekkekkeekeekkaekkkakeeeekkrvfvldFkG 105
                      ++++l++vv+ +++  ++ + k +++ t+++ + +++++ +++  l+  ++lk+ + +++++e+++++++ +++ + + +++ f+ + +G
       EFC36212.1  13 ILLLLLIVVVSLSCIINAASIKTTITTTTIESSNDKINNLIHQLKLSnIKSLKQSNHQQQHNEQQQHSNDANSNANVNVNEQTFLFNVNG 102
                      333333333333444444455556666666666666666665554442456666666666666666666645555566667777766665 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   1.8   2.6e-05     0.067       4      64 ..      10      86 ..       8      98 .. 0.35

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.6e-05
     DUF4834  4 Llfilifiiailviglsilsv..ilrtv..................fglgsrkkssksaqkqfgnstnsnqqksqsrsetk 64
                Llfil+++++++v    i+++  i  t+                  + l++ k+ ++s ++q++n+++++++  +s    +
  EFC36212.1 10 LLFILLLLLIVVVSLSCIINAasIKTTIttttiessndkinnlihqLKLSNIKSLKQSNHQQQHNEQQQHSNDANS----N 86
                4555444444444443343332244444555544444444444433222222222222222222222222222211....1 PP

>> AI-2E_transport  AI-2E family transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   3.9   4.5e-05      0.11      50     120 ..       7      80 ..       3     108 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.5e-05
  AI-2E_transport  50 vlavllvlllllvllvllvlllvplliaqltqlvkslpayidslqnilnelpslleele.n...liqalkqslsk 120
                      + + l++lllll+++ + +  +++ + + +t  +++++ ++d+++n++ +l+ +  +   +   ++q ++q+  +
       EFC36212.1   7 SNSLLFILLLLLIVV-VSLSCIINAASIKTTITTTTIESSNDKINNLIHQLKLSNIKSLkQsnhQQQHNEQQQHS 80 
                      445555655555554.45555556788888889999***********9999987777743354423333333333 PP

>> SIT  SHP2-interacting transmembrane adaptor protein, SIT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.9   6.8e-05      0.17       5      88 ..      10      92 ..       8     100 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.8e-05
         SIT  5 lilallLlllviasllawrmkkrqkkaaeysseqisredeevlqPieddicYanLnlqqtg..tspesseekcyeqmkssaqrsqn 88
                l++ llLll v++sl++ ++  + k + +++  +   +++ +++ +  ++  +n++  +++  +++ + +++ ++ ++s+a+ ++n
  EFC36212.1 10 LLFILLLLLIVVVSLSCIINAASIKTTITTTTIE---SSNDKINNLIHQLKLSNIKSLKQSnhQQQHNEQQQHSNDANSNANVNVN 92
                78899****************9999876664444...3444555444677778876544331133333344444444555555544 PP

>> Calc_CGRP_IAPP  Calcitonin / CGRP / IAPP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.3   7.2e-05      0.18       6      74 ..      12      82 ..       1     101 [. 0.62

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.2e-05
  Calc_CGRP_IAPP  6 fspllv.ilvlvqagslqaaplrsalelldsatlkeeesrlllarlvrdlvqlkaeeleqekeaee.sssd 74
                    f++ll+ i+v+    +++aa +++    ++ ++ +++ + l+ +   +++++lk+++++q+ ++++  s+d
      EFC36212.1 12 FILLLLlIVVVSLSCIINAASIKTTITTTTIESSNDKINNLIHQLKLSNIKSLKQSNHQQQHNEQQqHSND 82
                    33344447777777788999999988844445555555555555555668888777444444333223333 PP

>> DUF4446  Protein of unknown function (DUF4446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   3.4   0.00016       0.4       6      77 ..      12      84 ..       9      94 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00016
     DUF4446  6 lavlvvillillivllvklkklkkkykklmkgkdgksleellke.kleeveelkeeseelekeieeleeklkk 77
                +++l+++++++ + ++++  ++k+ +++ + +++++++++l+++ kl+++++lk+++++ +++ ++ +++ ++
  EFC36212.1 12 FILLLLLIVVVSLSCIINAASIKTTITTTTIESSNDKINNLIHQlKLSNIKSLKQSNHQQQHNEQQQHSNDAN 84
                3444444555566666777777777777777777777777777635677777777776644444433333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3299  (0.184004); expected 358.6 (0.02)
Passed bias filter:                     1282  (0.0715043); expected 358.6 (0.02)
Passed Vit filter:                       134  (0.00747392); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.68u 0.39s 00:00:01.07 Elapsed: 00:00:00.55
# Mc/sec: 1166.45
//
Query:       EFC36213.1  [L=259]
Description: small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.2e-24   83.9   0.0    1.3e-23   83.4   0.0    1.2  1  Ras           Ras family
    1.3e-12   48.0   0.2      9e-12   45.3   0.0    2.4  3  Roc           Ras of Complex, Roc, domain of DAPkinase
    7.7e-05   22.2   0.1    0.00011   21.7   0.1    1.3  1  Arf           ADP-ribosylation factor family
  ------ inclusion threshold ------
       0.17   12.5   3.0        1.9    9.1   0.6    2.3  2  LAG1-DNAbind  LAG1, DNA binding


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.4   0.0   2.9e-27   1.3e-23       1     157 [.      49     218 ..      49     223 .. 0.81

  Alignments for each domain:
  == domain 1  score: 83.4 bits;  conditional E-value: 2.9e-27
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHH.HHHTTESEEEEEEETTBHHHHHTHH.HHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslre.lyyrdaegillvyditsresfenvk.kwveei 97 
                 Kl +vG+s  GKtsl l+f +d+  ++  +T   d+++ +++++gke++l+i D  G +++++ r+ l y ++++++++y+i s++ +e+vk kw+ ei
  EFC36213.1  49 KLCIVGNSTSGKTSLALSFKEDD--RDLPHTT-LDEFNLKTMYQGKELTLTICDSKGSDDYDRYRTkLTYPNTNVFIICYSIVSKQQYESVKlKWIPEI 144
                 899****************9996..5556666.69999999**********************986268****************************** PP

                 HHHSTTTSEEEEEEETTTGGG............G-SS-HHHHHHHH.HHHT.SEEEEEBTT.TTCTHHHHHHHHH CS
         Ras  98 krvaeenvpivLvGnKvDlee............kravsteegeela.kelg.lkfletSAk.tnenveeafeell 157
                 ++ ++ n  i+L+++K+Dl++            + +v++      + +++  + + e+S   +n +v++++++++
  EFC36213.1 145 RMLCP-NALIILCATKTDLRDdhryissgllidRVQVKKLMDLYNHdQQYPiMFYNECSIYdQNVGVKDILDRAI 218
                 *****.69*************999999877754333333322222224444566778887514567888777666 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.41   1.8e+03      58      81 ..      14      37 ..       4      47 .. 0.67
   2 !   45.3   0.0     2e-15     9e-12       1     119 [.      49     161 ..      49     162 .. 0.82
   3 ?   -1.7   0.0      0.72   3.2e+03      71      90 ..     182     201 ..     179     249 .. 0.65

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.41
                EEEEEE-SGGCTTTT-HHHHCTSC CS
         Roc 58 lniWDtaGqerfrslhplylreaa 81
                l+ W    +e ++s+ +++ ++++
  EFC36213.1 14 LAAWEKRTEESTSSTSQSFRKSSS 37
                556666667777777777766554 PP

  == domain 2  score: 45.3 bits;  conditional E-value: 2e-15
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTT.T-HHHHCTSCEEEEEEE...GHHHHCH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrs.lhplylreaalailvyd...srssenl 95 
                 K+++vG+s++GKtsl+ +f ed+ +  ++  +  +f  k++   +        k+++l i D  G ++++   ++l + + +++i++y    ++++e++
  EFC36213.1  49 KLCIVGNSTSGKTSLALSFKEDDRDLPHT--TLDEFNLKTMY--Q-------GKELTLTICDSKGSDDYDRyRTKLTYPNTNVFIICYSivsKQQYESV 136
                 89******************999986654..44455555552..2.......46899************98356889999*******987645556677 PP

                 H.HHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  96 k.eWlkelkkvagkspvilvgnkiD 119
                 k +W+ e++  ++++ +il+++k+D
  EFC36213.1 137 KlKWIPEIRMLCPNALIILCATKTD 161
                 658*********************9 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.72
                 TT-HHHHCTSCEEEEEEEGH CS
         Roc  71 slhplylreaalailvydsr 90 
                 +l++ly ++++  i++y++ 
  EFC36213.1 182 KLMDLYNHDQQYPIMFYNEC 201
                 56666666666666666533 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.1   2.4e-08   0.00011       7     131 ..      40     166 ..      34     220 .. 0.77

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 2.4e-08
                 GGTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSS.SEEEEEEEE.TTEEEEEEEE-SSGGGGGGG.GGGCTTESEEEEEEETT-CTTHHHHHH CS
         Arf   7 klklkkkelrilllGLDnaGKtTilkklkleelvttvPTi.gfnveelei.knlkftvwDvGGqeklRplW.knYfektdavifvvDsadreRleeake 102
                 + +++++++++ ++G  ++GKt +   +k+++ +    T+  fn +++   k+l++t+ D  G +   ++  k  +++t++ i +   + ++  e  + 
  EFC36213.1  40 MNQQQQHSIKLCIVGNSTSGKTSLALSFKEDDRDLPHTTLdEFNLKTMYQgKELTLTICDSKGSDDYDRYRtKLTYPNTNVFIICYSIVSKQQYE--SV 136
                 34455899************************99988887369**99865599********9999887765155789999777776666666655..55 PP

                 HHHHHCTSGCCT.TSEEEEEEE-TTSTTSS CS
         Arf 103 eLkalleeeelk.evallvlaNKqDlpeal 131
                 +Lk + e + l  ++ +++ a K Dl+++ 
  EFC36213.1 137 KLKWIPEIRMLCpNALIILCATKTDLRDDH 166
                 688898888887466667778999999864 PP

>> LAG1-DNAbind  LAG1, DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.6   0.00042       1.9      33     123 ..      17     120 ..      12     139 .. 0.67
   2 ?    3.6   0.1     0.021        92      16      32 ..     143     159 ..     142     258 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00042
  LAG1-DNAbind  33 Wkakeetkeskeaelaapkltislsgedaeeesqllesigvsgkvseqesqelklvldgk.........caaktly........isdsdekrkevel 112
                   W++++e+++s+    ++++   s+s+++++++++ ++ + v +++s ++s +l+++ d +          ++kt+y        i ds+    + + 
    EFC36213.1  17 WEKRTEESTSS----TSQSFRKSSSTNMNQQQQHSIKLCIVGNSTSGKTSLALSFKEDDRdlphttldeFNLKTMYqgkeltltICDSKGSDDYDRY 109
                   76654444444....4444445555555566667777777777777777777777733334444445558999999999999999999999999999 PP

  LAG1-DNAbind 113 lvkllapngee 123
                     kl++pn++ 
    EFC36213.1 110 RTKLTYPNTNV 120
                   99999999644 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.021
  LAG1-DNAbind  16 EkRflcPppivyLlGsg 32 
                   E R+lcP  +++L  ++
    EFC36213.1 143 EIRMLCPNALIILCATK 159
                   779*********98773 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1554  (0.0866752); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1486.80
//
Query:       EFC36214.1  [L=289]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (289 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       810  (0.0451782); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1873.32
//
Query:       EFC36215.1  [L=464]
Description: B-like cyclin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.7e-45  152.4   2.5    5.5e-44  149.0   0.5    2.8  2  Cyclin_N        Cyclin, N-terminal domain
    4.3e-21   75.2   2.6    4.3e-21   75.2   2.6    2.1  2  Cyclin_C        Cyclin, C-terminal domain


Domain annotation for each model (and alignments):
>> Cyclin_N  Cyclin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  149.0   0.5   6.1e-48   5.5e-44       1     127 []     205     331 ..     205     331 .. 0.99
   2 ?    1.9   0.0     0.019   1.7e+02      44      65 ..     369     390 ..     358     403 .. 0.86

  Alignments for each domain:
  == domain 1  score: 149.0 bits;  conditional E-value: 6.1e-48
                 HHHHHHHHHHCHTS-STTCTTCTSSS-HHHHHHHHHHHHHHHHHTT--TTHHHHHHHHHHHHHHHS---CCCHHHHHHHHHHHHHHHHSSS---HHHHH CS
    Cyclin_N   1 dilknlieqelkflpkpdyldqqpelnpemRailidwlvevaekfkltpetlflavnyldRflskksvpkdklqlvgatcLllAaKveeisppkledlv 99 
                 di++++++ e+k+lp+++y+ +q++l+p+mRailidwl++v+ kf l petl+l++n++dRfls+k v++++lql+g+t++++A+K+eeis+p + d+v
  EFC36215.1 205 DIVNHYKSIEKKYLPDSNYMGRQQDLQPQMRAILIDWLIDVHCKFLLVPETLYLTINLVDRFLSEKAVSRQRLQLLGITAMFIASKYEEISSPIVADFV 303
                 7999*********************************************************************************************** PP

                 HHTTTSS-HHHHHHHHHHHHHHTTT--- CS
    Cyclin_N 100 yitdeafteeeilemErliLetLnfdls 127
                  it++a+t++e+l+mEr +L++L+f+l+
  EFC36215.1 304 KITKDAYTRDEVLRMERIMLQVLDFNLT 331
                 **************************95 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.019
                 HTT--TTHHHHHHHHHHHHHHH CS
    Cyclin_N  44 kfkltpetlflavnyldRflsk 65 
                 ++++tp+t+++a++yl + l++
  EFC36215.1 369 QLEFTPSTIACAAVYLSKHLTQ 390
                 7899************999884 PP

>> Cyclin_C  Cyclin, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0      0.95   8.5e+03      82     106 ..     199     218 ..     195     229 .. 0.59
   2 !   75.2   2.6   4.8e-25   4.3e-21       4     114 ..     336     452 ..     333     457 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.95
                 HHHHHHHHHHHHHGSS--HHCCCCT CS
    Cyclin_C  82 cvelilellssapssklqavrrkys 106
                 c e i++ +     ++++++ +ky 
  EFC36215.1 199 CTEYIKDIV-----NHYKSIEKKYL 218
                 444455555.....35677777776 PP

  == domain 2  score: 75.2 bits;  conditional E-value: 4.8e-25
                 HHHHHHHHCCSSHT.-HCCH.HCHHCHHHHHHCSCCHCCS-HHHHHHHHHHHCCHHH.HS--S-HHHHHHC---HHHHHHHHHHHHHHH.......HHH CS
    Cyclin_C   4 lsFlrrflkaadasedselr.tlakylleltlldydflsyppSliAaaalllarstl.nspewtetlehytgyskedlkpcvelilell.......ssa 93 
                 ++Fl+r+lk++    + el+  +a yl el+l+dy  l++ pS+iA aa++l+++   + ++w+  l+hyt+ s+ed+ pc++ +l++l        +a
  EFC36215.1 336 NVFLKRYLKCGRC--T-ELQtFIAIYLSELSLMDYAQLEFTPSTIACAAVYLSKHLTqDLEQWDLVLQHYTEKSEEDILPCARVMLKYLkkissqrRDA 431
                 78********665..5.444259*********************************978888***************************7776654445 PP

                 HGSS--HHCCCCTCGGGCCCG CS
    Cyclin_C  94 pssklqavrrkyssskfhkvs 114
                 +++ l a  +ky++++  ++s
  EFC36215.1 432 HTKPLVAAVNKYKKEDKLSAS 452
                 566668888888877755555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1005  (0.0560544); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2782.34
//
Query:       EFC36216.1  [L=324]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-30  106.2   0.2    3.9e-30  104.5   0.1    1.9  2  RNA_pol_A_bac  RNA polymerase Rpb3/RpoA insert domain
    1.5e-19   69.2   0.0    3.7e-19   67.9   0.0    1.7  1  RNA_pol_L      RNA polymerase Rpb3/Rpb11 dimerisation domain
  ------ inclusion threshold ------
      0.047   13.5   1.3      0.047   13.5   1.3    2.4  3  Fer4           4Fe-4S binding domain
        2.1    7.0   6.6        3.6    6.2   2.2    2.1  2  tRNA-synt_1g   tRNA synthetases class I (M)


Domain annotation for each model (and alignments):
>> RNA_pol_A_bac  RNA polymerase Rpb3/RpoA insert domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.5   0.1   8.8e-34   3.9e-30       1     112 []      54     177 ..      54     177 .. 0.97
   2 ?   -2.2   0.0       1.2   5.2e+03      74      90 ..     226     243 ..     205     245 .. 0.69

  Alignments for each domain:
  == domain 1  score: 104.5 bits;  conditional E-value: 8.8e-34
                    EEEEECTSSS.HHHHHCHHHCSTCBSSCHHHHHHHHCTT-ETSSSSTTCSEEEEEEEEESSEC...EEGGGCBESSSSCEES............ST CS
  RNA_pol_A_bac   1 VeieentsvlqDEvvaHrlgliplvsedvleillnlkelveeeeegeeeksvelkLnvkgpge...vtagdlkledadveiv............np 81 
                    Ve+e n+svl+DE++aHrlglipl+  ++   + ++ ++  +++ ++e++svel+L+vk+++    vt++dl ++++++ +             ++
     EFC36216.1  54 VEFEMNSSVLHDEFIAHRLGLIPLTCLNINS-FSYTSDC--SCTGHCEKCSVELTLHVKCTEShrdVTSNDLISNNPSCAPCtlsatsrdneneHN 146
                    78999********************999999.*******..8********************99***********9999999999999999999** PP

                    TSEEEEEETT-EEEEEEEEEEESSEECTTT- CS
  RNA_pol_A_bac  82 dilIakLrkgqeleleakvkkGiGkehakfs 112
                    +i I+kL+ gqe++l+a++kkG+Gk hak+s
     EFC36216.1 147 GITIVKLKRGQEIKLKAIAKKGVGKGHAKWS 177
                    ******************************8 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.2
                    SSC.EESSTTSEEEEEET CS
  RNA_pol_A_bac  74 adv.eivnpdilIakLrk 90 
                    ++v  + n+d lI+ L k
     EFC36216.1 226 TKVfSVTNDDRLIIDLDK 243
                    444044599999998875 PP

>> RNA_pol_L  RNA polymerase Rpb3/Rpb11 dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.9   0.0   8.2e-23   3.7e-19       1      69 []      24     310 ..      24     310 .. 0.82

  Alignments for each domain:
  == domain 1  score: 67.9 bits;  conditional E-value: 8.2e-23
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................................................................... RF
   RNA_pol_L   1 efllrgvdhtlgNaLRrillsevpgvaiea..................................................................... 30 
                 +f l++vd++++NaLRri+++evp++ai+                                                                      
  EFC36216.1  24 KFKLSNVDTSIANALRRIMIAEVPTLAIDLvefemnssvlhdefiahrlglipltclninsfsytsdcsctghcekcsveltlhvkcteshrdvtsndl 122
                 699**************************************************************************9999999999999999999999 PP

                 ............................................................................xx..................... RF
   RNA_pol_L  31 ............................................................................pv..................... 32 
                                                                                             pv                     
  EFC36216.1 123 isnnpscapctlsatsrdnenehngitivklkrgqeiklkaiakkgvgkghakwspvaittyyivpdirikgcqntPVnpsdqdnqtevpaadwigkfi 221
                 999999999999999999999999999999999999999988888888888888877777777777776666666622555555555556666666666 PP

                 ................................................xxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   RNA_pol_L  33 ................................................vkvn....tdkdklilevetdgslkPeealkeAlkiLkekl 69 
                                                                 v+++      k ++i++vet+gs +Pe++++ +++ L+ kl
  EFC36216.1 222 nscptkvfsvtnddrliidldkctycneckdfvndelipntspefkdfVSIKekdlGGKREFIFTVETTGSQTPENIVLLGFDTLVGKL 310
                 6666667777777777777777777777776666666666666666553333667788889***********************99876 PP

>> Fer4  4Fe-4S binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.3       2.4   1.1e+04      11      14 ..      97     100 ..      96     101 .. 0.59
   2 ?   -1.3   0.0      0.51   2.3e+03      16      22 ..     222     228 ..     221     230 .. 0.75
   3 ?   13.5   1.3     1e-05     0.047       2      15 ..     238     251 ..     237     253 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.4
                 -THH CS
        Fer4  11 CGaC 14 
                 C +C
  EFC36216.1  97 CEKC 100
                 6666 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.51
                 HHSTTTE CS
        Fer4  16 evCPvgA 22 
                 + CP+ +
  EFC36216.1 222 NSCPTKV 228
                 57**976 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 1e-05
                 EEETTTSSS-THHH CS
        Fer4   2 videekCigCGaCv 15 
                 +id +kC++C++C 
  EFC36216.1 238 IIDLDKCTYCNECK 251
                 79***********6 PP

>> tRNA-synt_1g  tRNA synthetases class I (M)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   2.2   0.00081       3.6     128     182 ..      86     142 ..      77     156 .. 0.87
   2 ?    2.8   0.1    0.0086        39     118     143 ..     242     267 ..     224     276 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.00081
                   EEE-GGG-EE........-TTS-EE-TTSSB-E..................EEE.EE CS
  tRNA-synt_1g 128 rflpdryvegtCPkckseeargdqceecgkklepteli..npksaisgskpevkete 182
                   ++ +d   +g+C kc  e     +c e+ + +++++li  np +a +  +++ +++e
    EFC36216.1  86 SYTSDCSCTGHCEKCSVELTLHVKCTESHRDVTSNDLIsnNPSCAPCTLSATSRDNE 142
                   56788999*****************************86689999999888877665 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.0086
                   EEEEEETTTTEEE-GGG-EE...... CS
  tRNA-synt_1g 118 ieqlycpkderflpdryvegtCPkck 143
                    + +yc++++ f +d+ +  t P+ k
    EFC36216.1 242 DKCTYCNECKDFVNDELIPNTSPEFK 267
                   5789**************99999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (324 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1890.24
//
Query:       EFC36217.1  [L=460]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       836  (0.0466284); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2920.58
//
Query:       EFC36218.1  [L=350]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.039   13.8   0.7      0.068   13.0   0.7    1.4  1  HAD_SAK_1   HAD domain family 1 in Swiss Army Knife RNA repai
       0.12   13.2   0.0       0.36   11.7   0.0    1.8  1  PRC2_HTH_1  Polycomb repressive complex 2 tri-helical domain


Domain annotation for each model (and alignments):
>> HAD_SAK_1  HAD domain family 1 in Swiss Army Knife RNA repair proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.7   7.6e-06     0.068      56     167 ..      35     168 ..      19     191 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 7.6e-06
   HAD_SAK_1  56 egwWnekivelarlsikdkdtltvlLTGRkekkFselierileskk..............lkfdavvLkkkvepsseefesTmeFKqafledl....le 136
                  +  n+++ +l ++s++ +dtl   LT ++ +k+ + ++r  +s +              ++f+++v + ++ p+ +e + T  + ++f+ ++    ++
  EFC36218.1  35 TTTTNQQVFNLSQNSVTYEDTLHTFLTEKDGNKYYKGFKRTYKSTNneivreqmfwigdfIQFNIFVSQTEP-PTIHEGKITSVYSCTFMGNIkkckVQ 132
                 55669**************************************84444555567777777999999888765.66668888888888888776332222 PP

   HAD_SAK_1 137 tyksleeit.....iYedrpkhvkkfkefleklnkk 167
                  ++s ee++     + ed  k+ + f++++++l+ +
  EFC36218.1 133 MLRSHEEVKsmmgvVGEDLMKKKDDFRRYMTDLEGE 168
                 333333332111225577777777777777776655 PP

>> PRC2_HTH_1  Polycomb repressive complex 2 tri-helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0     4e-05      0.36       5      93 ..     200     313 ..     197     319 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4e-05
  PRC2_HTH_1   5 egsfiddeiFve.LvnaLmqyeekeeeseseskekksekkkkkkkaeedeeke........................ekikkekskekkkfpadiiFqa 78 
                 + + id++ ++e L n L+q+++++++++ + ++ + +   k+ k+  +++ +                         ki ++++ +  +  ++ii   
  EFC36218.1 200 QVNTIDNDCYIEkLTNPLSQTNSQQQTNSVTIQSLTFSWAMKDYKSPPSNHYDyyssciigsgsllmlsvgnvcqleIKIPQSQQLNVGAPTSKIIMGR 298
                 6688999***987889999999999999999988887766555555444444478999999999999999999999888888899999999999***** PP

  PRC2_HTH_1  79 IssvFPdkGtpeelk 93 
                 +s++F dk t e+lk
  EFC36218.1 299 VSKMFEDKTTLENLK 313
                 **************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       679  (0.0378716); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 2051.48
//
Query:       EFC36219.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.7e-32  112.3   0.2    4.3e-32  111.7   0.2    1.3  1  Isochorismatase  Isochorismatase family
  ------ inclusion threshold ------
      0.028   14.1   0.1      0.048   13.3   0.1    1.3  1  Zot              Zonular occludens toxin (Zot)


Domain annotation for each model (and alignments):
>> Isochorismatase  Isochorismatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.7   0.2   4.8e-36   4.3e-32       2     175 .]      27     226 ..      26     226 .. 0.84

  Alignments for each domain:
  == domain 1  score: 111.7 bits;  conditional E-value: 4.8e-36
  Isochorismatase   2 alvviDmqndfveegvkeseeisavveninkllkaarkagip.viftrdvhe................leevkgdlderkaaphfkpgttgael 78 
                      al+++D+qndf+e+g  ++ ++++v+e  n   +++   ++  ++ t+d h+                ++  +  +++  ++ h+++gt+gae+
       EFC36219.1  27 ALIIVDVQNDFLEGGSLAVDNANDVIEVFNNIRQSV---NWDlIVLTQDFHPrnhisfavnhdmpvmsTKIMEDGTEQIMWPVHCVQGTRGAEF 117
                      9***********555555555555555555555555...4663555666666*************644333333345667999*********** PP

  Isochorismatase  79 vpelaplegdvvvdKt......rfsaf......agtdldeiLkelgiktivlaGiatdvCVeatardaldlGyevvvvsDAvaalspelhdaal 160
                      +p+l +  +d+vv+K        +s+f       +t+ldeiLk++gi++ ++aG+a dvCV+ t +d + lGy++++++DA  ++s++ ++ al
       EFC36219.1 118 HPDLIVEDDDIVVEKGcntnvdSYSGFfdnnkkHQTKLDEILKSHGITDTYIAGVALDVCVKYTSLDSVSLGYNTFLIKDASRGVSQDSVKIAL 211
                      ***************999999999999******************************************************************* PP

  Isochorismatase 161 krlkqafatvitted 175
                      +++k+a ++++ +ed
       EFC36219.1 212 QEMKEASVHIVNSED 226
                      ****99999998875 PP

>> Zot  Zonular occludens toxin (Zot)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   5.3e-06     0.048      77     127 ..      22      73 ..       7      85 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.3e-06
         Zot  77 tidkgallviDEcqeifpvrakegrkdpevinaftehRh.lgwDivlltqdi 127
                 +i k al+++D  + +    +  + + ++vi+ f + R+  +wD++ ltqd+
  EFC36219.1  22 RIRKRALIIVDVQNDFLEGGSLAVDNANDVIEVFNNIRQsVNWDLIVLTQDF 73 
                 44699******88888888888899999**********956*********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       479  (0.0267165); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.56
# Mc/sec: 1218.04
//
Query:       EFC36220.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-08   34.4   0.1    5.3e-08   33.3   0.1    1.6  1  Ank_2     Ankyrin repeats (3 copies)
    3.8e-07   30.5   0.2    4.8e-05   23.8   0.0    2.6  3  Ank_4     Ankyrin repeats (many copies)
    2.1e-05   24.6   1.9    0.00027   21.2   0.1    3.0  2  Ank_3     Ankyrin repeat
    2.1e-05   24.7   0.4    8.5e-05   22.8   0.1    2.2  2  Ank_5     Ankyrin repeats (many copies)
      0.002   18.5   0.3      0.023   15.2   0.0    2.6  2  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.1   1.5e-11   5.3e-08      25      82 ..      41     110 ..      16     111 .. 0.74

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 1.5e-11
       Ank_2  25 ngktaLh...yAakngnleivklLleh....ad.....ndgrtpLhyAarsghleivklLlekgadinlk 82 
                  g+++L+    ++  +nle++ +L+++    ++     +++ + Lhy+  ++++eivk+L+e+g+d+n++
  EFC36220.1  41 SGLNPLIamrKCCFVNNLECATYLIDNgivhINdiceeSHNFSWLHYCTHYNSIEIVKYLIENGIDVNIR 110
                 455555511145555999*******97776633455577799*******99*****************87 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0      0.06   2.1e+02      38      55 .]      48      65 ..      33      65 .. 0.73
   2 ?    3.9   0.1     0.024        86      12      30 ..      56      75 ..      48      88 .. 0.71
   3 !   23.8   0.0   1.3e-08   4.8e-05       5      38 ..      85     118 ..      83     119 .. 0.96

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.06
       Ank_4 38 alhiAakrgnveilklLl 55
                a+ +++  +n+e++ +L+
  EFC36220.1 48 AMRKCCFVNNLECATYLI 65
                68899999********98 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.024
       Ank_4 12 grlelvrlLlekg.adinaq 30
                ++le++ +L+++g + in  
  EFC36220.1 56 NNLECATYLIDNGiVHINDI 75
                68899999999985557765 PP

  == domain 3  score: 23.8 bits;  conditional E-value: 1.3e-08
       Ank_4   5 LhyaaisgrlelvrlLlekgadinaqdnrsGeta 38 
                 Lhy+ +++ +e+v++L+e+g+d+n + +r+G+ta
  EFC36220.1  85 LHYCTHYNSIEIVKYLIENGIDVNIRESRNGNTA 118
                 899999***************************8 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.2      0.15   5.3e+02       9      30 ..      52      73 ..      41      74 .. 0.77
   2 !   21.2   0.1   7.4e-08   0.00027       6      31 .]      85     109 ..      80     109 .. 0.94

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.15
       Ank_3  9 AarsgnleivkfLlenkgadvn 30
                ++  +nle + +L++n  + +n
  EFC36220.1 52 CCFVNNLECATYLIDNGIVHIN 73
                56677888999****8777776 PP

  == domain 2  score: 21.2 bits;  conditional E-value: 7.4e-08
       Ank_3   6 LhlAarsgnleivkfLlenkgadvna 31 
                 Lh++ +++++eivk+L+e +g+dvn+
  EFC36220.1  85 LHYCTHYNSIEIVKYLIE-NGIDVNI 109
                 9*****************.8*****7 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.1   2.4e-08   8.5e-05       6      52 ..      71     118 ..      56     120 .. 0.87
   2 ?   -1.4   0.0      0.93   3.4e+03       8      25 ..     196     215 ..     193     221 .. 0.60

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 2.4e-08
       Ank_5   6 padvnrldgggntpLhvAakygaadvvrlLlargadlnltdsrG.lta 52 
                 +++  +++ + ++ Lh+  +y++ ++v++L+++g d n+++sr+ +ta
  EFC36220.1  71 HINDICEESHNFSWLHYCTHYNSIEIVKYLIENGIDVNIRESRNgNTA 118
                 56677778888899999999************************9997 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.93
       Ank_5   8 dvnrldgggn..tpLhvAak 25 
                 +++++d +gn  t+ +++++
  EFC36220.1 196 NCDDSDSDGNesTVSNTSSS 215
                 45666666664466666655 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.42   1.5e+03      10      24 ..      53      68 ..      41      75 .. 0.72
   2 !   15.2   0.0   6.3e-06     0.023       6      30 ..      85     110 ..      85     112 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.42
                HHHTTHHHHHHHH.TT CS
         Ank 10 atngkkriiklLL.hG 24
                +  ++++++ +L+ +G
  EFC36220.1 53 CFVNNLECATYLIdNG 68
                4557799999999668 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 6.3e-06
                 HHHHHHHTTHHHHHHHH.TTTSTTCB CS
         Ank   6 LHlAatngkkriiklLL.hGAnlnal 30 
                 LH++ ++++ +i+k+L+ +G ++n++
  EFC36220.1  85 LHYCTHYNSIEIVKYLIeNGIDVNIR 110
                 9**77************99*****97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       940  (0.052429); expected 358.6 (0.02)
Passed bias filter:                      539  (0.030063); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.51
# Mc/sec: 1488.14
//
Query:       EFC36221.1  [L=215]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.4e-41  140.3   6.8    7.6e-41  140.1   6.8    1.0  1  Ribosomal_L1  Ribosomal protein L1p/L10e family


Domain annotation for each model (and alignments):
>> Ribosomal_L1  Ribosomal protein L1p/L10e family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  140.1   6.8   4.2e-45   7.6e-41       4     203 ..      20     208 ..      13     209 .. 0.96

  Alignments for each domain:
  == domain 1  score: 140.1 bits;  conditional E-value: 4.2e-45
                   HS-SSS--EEEEEEEESSS-TTSGGG--EEEEE-STSTSSCS-EEEEE-HHHHH...HHHHTT..-SEEETCHHHHHHT-HHHHHHTCCH-SEEEEE CS
  Ribosomal_L1   4 hakkkfdesveialnlttkkpkkadqrkpgkipLphplgkevkiclitkdpqaeyakeakeagriakviglkklkkkyksfeakrkllkefdlflad 100
                     k+kf ++v+++++l++++p k d+r++g+++Lp+ ++k++k+c++ +++++e    ake g    + ++++lk+  k+++  +kl++++d fla+
    EFC36221.1  20 KNKRKFVQTVDLQIKLKNYDPSK-DKRFNGSLKLPNYVKKNLKVCILGDHNHCE---RAKELG--IPFKTVDDLKNTNKNKKIVKKLADSYDAFLAS 110
                   5699****************665.99****************************...9*****..99****************************** PP

                   GGGHHHHHHHCHHHHGGGT-S-ECC..CT.BTS-HHHHHHHHCTTEEEEE-TTTSEEEEEEEETTSSHHHHHHHHHHHHHHHHHTSTTTSGSEEEEE CS
  Ribosomal_L1 101 drimpllpklLGkvfgkrkkmPipvltkgtvkedvkkevekalkstvvvrldkgtclsvkvGklsftaeelaeNieavvkalvekvpkkwkniksiy 197
                   d++++++p+lLG+ ++k++k+P      g+ ++d+ +++e+++k tv+++l+k+ +l+ ++G++++++ee+ +N++ ++++lv+ ++k+w+n+ +  
    EFC36221.1 111 DSLIKRIPRLLGPGLSKAGKFPLVL---GQ-NDDIPAKIEELKK-TVKFQLKKEINLATAIGNVEMPEEEVQQNVTIALNFLVSLLKKNWQNVGAAN 202
                   *************************...33.689**********.**************************************************** PP

                   EEETTS CS
  Ribosomal_L1 198 lkttms 203
                   +k tm+
    EFC36221.1 203 IKATMG 208
                   *****9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       806  (0.0449551); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.28s 00:00:00.69 Elapsed: 00:00:00.44
# Mc/sec: 1464.89
//
Query:       EFC36222.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.1e-05   24.1  18.3    3.4e-05   24.0  11.0    2.0  2  DUF3430      Protein of unknown function (DUF3430)
     0.0084   16.0   8.7      0.017   15.0   8.7    1.6  1  Furin-like   Furin-like cysteine rich region
  ------ inclusion threshold ------
      0.015   15.1   2.5      0.015   15.1   2.5    2.2  2  GF_recep_IV  Growth factor receptor domain IV
      0.027   14.5   1.2       0.14   12.1   0.0    2.2  2  DUF2116      Uncharacterized protein containing a Zn-ribbon (


Domain annotation for each model (and alignments):
>> DUF3430  Protein of unknown function (DUF3430)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0  11.0   7.5e-09   3.4e-05       1     122 [.       1     118 [.       1     121 [. 0.67
   2 ?    3.0   3.1      0.02        89      25     111 ..     122     160 ..     113     174 .. 0.54

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 7.5e-09
     DUF3430   1 MKllfslilllllllnfl..insqyinfipyqsekCsgegsssgigysieideCitnd...........nqnnyvfsvftdssdgeiiktnyyedqnCe 86 
                 MK     +l++  ++++l  ++ qy  f+++++++Cs    ++ +   +  + C  ++           ++++  +s     ++g++++++y + + C 
  EFC36222.1   1 MKS---TLLFIAAFIALLglVSAQYQTFTYFTDSSCS--AANYVYEKTVPASACTGSNattactatknyYYTSACVSAYPSTVNGFMFTSEYDN-STCV 93 
                 777...34444444444456*****************..6667777666655566666666666544433333333334455677777777777.**** PP

     DUF3430  87 gkpistftfeigsCvstpefvnnasnsssyysykvs 122
                 g+ +s  +++ g C+           s+ +ysyk++
  EFC36222.1  94 GDVKSVTRYKLGACYI----------SG-SYSYKYT 118
                 ***************9..........33.3666665 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.02
     DUF3430  25 nfipyqsekCsgegsssgigysieideCitndnqnnyvfsvftdssdgeiiktnyyedqnCegkpistftfeigsCvstpefvnnas 111
                  +i+y++  C+  g s   g +i +d+C ++                                                 ++v+++ 
  EFC36222.1 122 RWITYTDTACTTAGTSGASGVAIPVDTCQSSY------------------------------------------------NIVQKCV 160
                 45566666666666655555666666665555................................................3333332 PP

>> Furin-like  Furin-like cysteine rich region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   8.7   3.7e-06     0.017      55     141 ..      45     153 ..      19     171 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 3.7e-06
                 BESEBSSTT.TTSBSSBSSEEETTEEESS--T.......................TEEEETTEEEEHHHHHHH...........T-SSS----EEETTE CS
  Furin-like  55 ClggCtepk.dsdCvaCrklndegtCvekCPp.......................kkykfgarCvtekeCpkl...........skeeeeeelvieege 118
                  ++ Ct+++ +++C+a ++++++ +Cv++ P+                       ++yk             l           + ++e++ ++ ++++
  EFC36222.1  45 PASACTGSNaTTACTATKNYYYTSACVSAYPStvngfmftseydnstcvgdvksvTRYK-------------LgacyisgsysyKYTNECRWITYTDTA 130
                 4778**999999********************999988665555555555555554444.............044444444443677777778888888 PP

                 EESS--TTEEE-.TTT-BEEE-S CS
  Furin-like 119 CvlecpsgktevekeskkCekCe 141
                 C+++  sg   v+  + +C+   
  EFC36222.1 131 CTTAGTSGASGVAIPVDTCQSSY 153
                 88888888877776666666544 PP

>> GF_recep_IV  Growth factor receptor domain IV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   2.5   3.3e-06     0.015      42     103 ..      24      83 ..      17     100 .. 0.79
   2 ?    0.8   3.0     0.088   3.9e+02      83     119 ..     127     163 ..      85     179 .. 0.47

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 3.3e-06
  GF_recep_IV  42 ereyeeekkCvkChpeCeklnesetCsgpga.deClkCahfkdgseCvseCPegvkgekelif 103
                  + +y ++++C + +   ek+  +++C+g++a + C++ +++  +s Cvs  P++v+g   ++f
   EFC36222.1  24 TFTYFTDSSCSAANYVYEKTVPASACTGSNAtTACTATKNYYYTSACVSAYPSTVNG---FMF 83 
                  45677789999999999999999*****987257********************975...344 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.088
  GF_recep_IV  83 dgseCvseCPegvkgekelifkyadaeevCekChenc 119
                  +++ C +   +g++g   ++  ++++ ++ +kC ++ 
   EFC36222.1 127 TDTACTTAGTSGASGVAIPVDTCQSSYNIVQKCVKQS 163
                  2233333333333333333333333333333333333 PP

>> DUF2116  Uncharacterized protein containing a Zn-ribbon (DUF2116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.2      0.12   5.3e+02      37      53 ..       2      18 ..       1      21 [. 0.81
   2 ?   12.1   0.0   3.2e-05      0.14      22      56 ..     147     183 ..     130     185 .] 0.78

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.12
     DUF2116 37 rsqqilfgililllavv 53
                +s  ++++++i+ll +v
  EFC36222.1  2 KSTLLFIAAFIALLGLV 18
                677899999**999875 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 3.2e-05
     DUF2116  22 ekCqeeyekkrk..kvarsqqilfgililllavvlvl 56 
                 + Cq+ y+  +k  k+ + q+i + +++l+ a+v +l
  EFC36222.1 147 DTCQSSYNIVQKcvKQSNAQMIGVSAVALIFAIVSFL 183
                 89*****987774477888999999999999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1129.16
//
Query:       EFC36223.1  [L=841]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0051   16.6   0.2     0.0051   16.6   0.2    2.2  2  Peptidase_C97  PPPDE putative peptidase domain


Domain annotation for each model (and alignments):
>> Peptidase_C97  PPPDE putative peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.2     0.086   1.5e+03      71     109 ..     296     340 ..     270     364 .. 0.66
   2 !   16.6   0.2   2.8e-07    0.0051      76     120 ..     650     695 ..     584     698 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.086
                    -SEEEEEEEE---HHHHHHHHHHHHTT......--GGG-BTTTB- CS
  Peptidase_C97  71 presieigeTevteeevraileelsse......ytgdkYnLiskN 109
                    +++ ++i e ++t+++ +  l+++s +      +++++Y+L s+N
     EFC36223.1 296 WQSLVNINENDITHNQSKMDLSNVSVHhyeeteFEPNAYELKSRN 340
                    445556666666666666666666654445555777777777777 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 2.8e-07
                    EEEEE---HHHHHHHHHHHHTT--GG.G-BTTTB-HHHHHHHHHHH CS
  Peptidase_C97  76 eigeTevteeevraileelsseytgd.kYnLiskNCnhFtdelvdf 120
                     +++ e + ++  +++ ++  e++g+ +Y+  ++NC+hFt++++++
     EFC36223.1 650 VMITKETDIHRCLDMIAQVCCEWNGTqTYDNKKNNCQHFTQAVLEK 695
                    4444455556777777777779**9626**************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (841 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1700  (0.0948185); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.55
# Mc/sec: 4632.24
//
Query:       EFC36224.1  [L=940]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   8.2e-135  450.9  29.6    1.6e-89  301.1  23.4    5.1  5  Hid1         High-temperature-induced dauer-formation protein
   9.4e-123  410.8  18.3   2.2e-108  363.4  14.3    2.1  2  Dymeclin     Dyggve-Melchior-Clausen syndrome protein
  ------ inclusion threshold ------
       0.11   12.6   0.1       0.24   11.4   0.1    1.6  1  HTH_Tnp_Tc5  Tc5 transposase DNA-binding domain


Domain annotation for each model (and alignments):
>> Hid1  High-temperature-induced dauer-formation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.7   0.0   1.1e-29   6.8e-26       1     122 [.       1     118 [.       1     131 [. 0.93
   2 ?   -8.8  17.0         3   1.8e+04     617     690 ..     142     219 ..     129     249 .. 0.39
   3 ?  -10.0  31.8         3   1.8e+04     579     686 ..     254     361 ..     237     382 .. 0.39
   4 !  301.1  23.4   2.7e-93   1.6e-89     136     573 ..     362     797 ..     352     822 .. 0.91
   5 !   79.2   0.2   3.4e-26     2e-22     682     812 .]     811     935 ..     796     935 .. 0.91

  Alignments for each domain:
  == domain 1  score: 90.7 bits;  conditional E-value: 1.1e-29
        Hid1   1 MgasesklafkkaifrLgekrliaeddayweefWelpesteDvFeLltpadirkvRdenleNletLilavierlvelakhpsfpdpeqapeseaLnCvR 99 
                 Mg+s+sk++fk  + +Lge+  + ++  +w+++   p s++D+F+++tp+dir +R ++++Nl t+i++ ie+l   ++ ++      a+ ++a n + 
  EFC36224.1   1 MGSSDSKIEFKTMFSKLGENYIKHNEHNFWKHLFIQPLSIDDIFSIITPDDIRSLRISQPANLGTIIYKCIEQLYLFSQPKNY----SAESTSAKNSLH 95 
                 *****************99988888888**********************************************999988776....68889999**** PP

        Hid1 100 lLtrllPfifEeesleewedklf 122
                 lLtr+lPf+fE++++  + d +f
  EFC36224.1  96 LLTRILPFVFEHDNDGFVTDLFF 118
                 *************9999999665 PP

  == domain 2  score: -8.8 bits;  conditional E-value: 3
        Hid1 617 rspslsevpelksslaitddeskaereks.atessssqavs...qlremsekarakesaesteesrqesatskkspsg 690
                 ++ ++++++++ ++  +t++e++ ++  s at+++ +q+++   ql+e  e++ +++++  tee+ +es+t++ +++ 
  EFC36224.1 142 KQEETKQQETTPDTTTTTPSEENPTEPAStATTEQIEQIKQgieQLKEKVEEKLEEQPEVTTEEKSTESTTEPPKETV 219
                 222223333333333333333333332220222222222222222333333333333333333333333333333222 PP

  == domain 3  score: -10.0 bits;  conditional E-value: 3
        Hid1 579 aseeiersnesarldsideeeeenssessrieesrsesrspslsevpelksslaitddeskaereksatessssqavs....qlremsekarakesaes 673
                 +s++++++++ ++++  + +eee+  e++++e+ ++ s+++s++e+++++++  ++  e+++++e++++++++ + ++    +++e++e   ++ ++e 
  EFC36224.1 254 SSKKKKKNKK-KNKKGGNAKEEEKVVEEEKTETPTEVSSQASTTEESSTTTETVEETPEEPKQEETKEEPKEEVKETTpeepKQEEVKE---ETTQQEA 348
                 2222222222.333333333333333333333334555555555555555444444444444444444443333322222221112222...2222221 PP

        Hid1 674 teesrqesatskk 686
                 t  +++++  +++
  EFC36224.1 349 TPVEASQEPVQQE 361
                 1111111111111 PP

  == domain 4  score: 301.1 bits;  conditional E-value: 2.7e-93
        Hid1 136 asevledesssee.......eeeeekekplaeelldalvdlLFlkdFTvpapk........sskskveysiWesGvgtatklps..nkeiesnRtEvLk 217
                 +++v+++ ++s +        ++ + ++ lae ++++l++ LFl+dFTvp  +        ++   +e ++W++G  t+ k+ +    e ++nR  +L+
  EFC36224.1 362 STSVVQTTQESASkllpilkIADTNLTTSLAEVMIQTLMRCLFLPDFTVPISQlheeqiliKTDTLDESVLWQTGMATHGKPLRsaSWEQMENRNDILR 460
                 3333443333333788888767888999********************************9888889999***********99955667778******* PP

        Hid1 218 lLLtlfsetlYrspsevssngskvltylvssdnrqevltLlcSLlntvcrydpsgsglpynsvvlkdsrellVeyclqlLlvlldypipedeklseevk 316
                 ++Lt+fs+ lY+  +   +  +k+l   vs + ++ + +Ll SLln v +ydp+gs lpy+s +++d     +e +l ++ vll++ ++++++      
  EFC36224.1 461 CMLTCFSSVLYQDAEICAEYDNKFLSIAVSDKIPN-AHNLLYSLLNFVTAYDPRGS-LPYSSQLFTDYYTQYIETSLHMMSVLLQHKPKNQTNI----- 552
                 *************99999*****************.9*****************96.9*****************************9999999..... PP

        Hid1 317 tertsskpkNlfriylgrlhreqdfqFlldgltriLnqplq..ssylpnsqksvkfaqelliLlwellqcNkrFrsfviessrvldllvlilyylveyr 413
                           +  i+  +   + d+  l + lt +L+++++   +ylp+sqk ++f+ e+l L+w +l     Fr f ++  ++ dllv++l+ +    
  EFC36224.1 553 ----------YHQILQHQFNNTVDMTHLYSKLTLLLRNVVDshYTYLPSSQKLIEFYEEVLLLFWLILGEAPVFRIFACKELNITDLLVPLLFIIQLHS 641
                 ..........4555666777789******************9999************************************************999999 PP

        Hid1 414 sdqskkglvkicvfillllSseknfgkrLnkpfeaqeslptsiripvftgtyaDfliisihkllttgkeklsslvdtLleiLvnispylktLsleacsk 512
                 ++ +k+ +v++ +f +lllS++++fg++Ln+p++   + p  +++p f+g yaD+li+ + k++ t k+  + l+d++l+i+ nispy k+L++ ++ k
  EFC36224.1 642 KQITKFPIVQLASFTVLLLSGNREFGVALNQPYKI--TAP--LDVPAFEGNYADLLILFFNKVMVTDKGAIRGLYDCMLTIIANISPYTKSLTMLSSVK 736
                 999********************************..999..********************************************************* PP

        Hid1 513 llqLlesfSspsfLlanesNhkllalllealnnviqkqfkgnrnLvYsilrkrkvfealrn 573
                 ll+L+e+f sp fL+++e+Nh+++allle++nn+iq+q++gn   +Ysilr  k f+ l +
  EFC36224.1 737 LLNLFEAFASPRFLYSSERNHQFVALLLEVFNNIIQYQYEGNVHVIYSILRRGKLFQDLEK 797
                 *********************************************************9975 PP

  == domain 5  score: 79.2 bits;  conditional E-value: 3.4e-26
        Hid1 682 atskkspsgmsqsaeekftptsewlesWksklpLetiltllkallpkiekiaseegltdeseiLkflkdktlvgllpepspikirkfewsalslgWyes 780
                  +++k ++++ q   e f pt+ew++sW++ lp+ ti+tl++ l+p+ie+i+s+e +t+e  ++  lk++tlvgllp+p+ i ir+f+ ++    + ++
  EFC36224.1 811 RHEQKIAENQNQPLPEPFLPTHEWVQSWRPRLPIYTIITLINTLSPDIERICSKEYATEE-DVIVYLKNTTLVGLLPVPHTIIIRTFQGNPKIDTFIIT 908
                 56666777788889999*************************************777766.79999********************************* PP

        Hid1 781 llwgviynreenvkkltavgvwndtevkLfki 812
                 ++wg +y + +     t v+  ++++++Lf i
  EFC36224.1 909 FVWGCVYVKMS-----TRVPWVDSKQIRLFTI 935
                 *******9999.....899999********87 PP

>> Dymeclin  Dyggve-Melchior-Clausen syndrome protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.5   0.1   3.8e-17   2.3e-13       1     122 [.       1     150 [.       1     203 [. 0.81
   2 !  363.4  14.3  3.7e-112  2.2e-108     128     627 ..     385     912 ..     329     913 .. 0.93

  Alignments for each domain:
  == domain 1  score: 49.5 bits;  conditional E-value: 3.8e-17
    Dymeclin   1 MGassSklafrkavlqllsktqpida.ddafWdqllsfslktptsvqdvfalvepaaeilalrnespgnLatLlrkaveklvelkescssakeqqtals 98 
                 MG+s+Sk +f k ++ +l +++ i++ +++fW++l+     +p+s +d+f + ++  +i+ lr  +p nL t+++k++e+l   +++ + + e+    +
  EFC36224.1   1 MGSSDSKIEF-KTMFSKL-GENYIKHnEHNFWKHLFI----QPLSIDDIFSI-ITPDDIRSLRISQPANLGTIIYKCIEQLYLFSQPKNYSAES----T 88 
                 *********9.6656665.55589999*********6....889999****9.*********************************66666664....4 PP

    Dymeclin  99 qalNalrllrrilkyllerasee......................................e 122
                 +a N+l ll+ril++++e+ ++                                       e
  EFC36224.1  89 SAKNSLHLLTRILPFVFEHDNDGfvtdlffnnvlpgsaglqsvvggatkpietkqeetkqqE 150
                 6***************9988888888888888888888888777777777766433233320 PP

  == domain 2  score: 363.4 bits;  conditional E-value: 3.7e-112
    Dymeclin 128 seeaeplaeslllalvdllfcpdftvps.k.................................sdstyalrtellklLlvllseqlysppssadssafn 192
                 ++ +++lae ++++l+++lf+pdftvp  +                                 s + +++r+ +l+++l+++s+ ly++++ + +   n
  EFC36224.1 385 TNLTTSLAEVMIQTLMRCLFLPDFTVPIsQlheeqiliktdtldesvlwqtgmathgkplrsaSWEQMENRNDILRCMLTCFSSVLYQDAEICAEY-DN 482
                 456788*********************9636678999**************************66689*********************9999999.6* PP

    Dymeclin 193 klldgktsaenrialplvtsLLntviaydpvdesdagsgvpynhllfsdaaasleplveqslqlLlvlldhdktekavaeesestaeesNlfrnyLsri 291
                 k+l+++ s++ + a++l++sLLn v aydp      g ++py++ lf+d+     +  e+sl++++vll+h++ +++            N++ ++L++ 
  EFC36224.1 483 KFLSIAVSDKIPNAHNLLYSLLNFVTAYDPR-----G-SLPYSSQLFTDYY---TQYIETSLHMMSVLLQHKPKNQT------------NIYHQILQHQ 560
                 *******************************.....5.799**********...*****************998887............*******987 PP

    Dymeclin 292 hreeesdadfkfilkglfrllnntvpseqtylpns..kiqfhqelllllykLlhsNkkfleyvlkrsdvldllvPiLellydaradqsrvgliyillfi 388
                  ++    +d++  +++l+ ll n v s  tylp+s   i+f++e+lll++++l + + f+ ++ k+ ++ dllvP+L+++   +++ ++++ ++++ f+
  EFC36224.1 561 FNNT---VDMTHLYSKLTLLLRNVVDSHYTYLPSSqkLIEFYEEVLLLFWLILGEAPVFRIFACKELNITDLLVPLLFIIQLHSKQITKFPIVQLASFT 656
                 7777...69999************************889****************************************99999999************ PP

    Dymeclin 389 LLlLSgdrnfgvrlnkliiksvpyservpmdisvftgtlgdLlilvlhrlitynhqrlqDkpLhtcllaiLaNvSpylknLsmvasqkLvsLlellskk 487
                 +LlLSg+r fgv+ln++      y+ + p+d+++f+g ++dLlil + +++++    ++   L++c+l+i+aN+Spy k+L+m +s+kL++L+e+++++
  EFC36224.1 657 VLLLSGNREFGVALNQP------YKITAPLDVPAFEGNYADLLILFFNKVMVTDKGAIR--GLYDCMLTIIANISPYTKSLTMLSSVKLLNLFEAFASP 747
                 *****************......************************************..************************************** PP

    Dymeclin 488 wfllsaeakasddlaqelsvneelvrllleilnsiLqyqldgNsnLVYallrkrevfaalanlptdfad.............................. 556
                 +fl+s+e             n+++v+llle++n+i+qyq++gN +++Y +lr+ ++f+ l++ p+ ++                               
  EFC36224.1 748 RFLYSSER------------NHQFVALLLEVFNNIIQYQYEGNVHVIYSILRRGKLFQDLEKDPE-LEPirtailkrheqkiaenqnqplpepflpthe 833
                 ********............********************************************9.555788888888888888888888888888888 PP

    Dymeclin 557 .........plqnimrvlqvlvpqvekicadkgsldeseilkviqkgtlvgllpvphpilirkYqeeegteefFrpYvWg 627
                          p+ +i++++++l+p +e ic ++   +e+ ++ +++++tlvgllpvph+i+ir++q + +  +f +++vWg
  EFC36224.1 834 wvqswrprlPIYTIITLINTLSPDIERICSKE-YATEEDVIVYLKNTTLVGLLPVPHTIIIRTFQGNPKIDTFIITFVWG 912
                 8888888888888*****************94.4999999***************************************8 PP

>> HTH_Tnp_Tc5  Tc5 transposase DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1     4e-05      0.24      20      62 ..     802     844 ..     796     848 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4e-05
                  ---SCHHHHHHHHHHHHHSSSCT-TT-S--CHHHHHHHHHTS- CS
  HTH_Tnp_Tc5  20 ipitgelirekAqelaslaadlgepdfkaSkgWldrFkkRhgl 62 
                  +pi+++++++  q++a++  ++ +++f++ ++W++ ++ R+++
   EFC36224.1 802 EPIRTAILKRHEQKIAENQNQPLPEPFLPTHEWVQSWRPRLPI 844
                  59999***********8889******************99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (940 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2635  (0.146969); expected 358.6 (0.02)
Passed bias filter:                      646  (0.036031); expected 358.6 (0.02)
Passed Vit filter:                       210  (0.0117129); expected 17.9 (0.001)
Passed Fwd filter:                        79  (0.00440627); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.89u 0.44s 00:00:02.33 Elapsed: 00:00:00.67
# Mc/sec: 4259.39
//
Query:       EFC36225.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.57   10.0   3.2       0.34   10.7   0.4    2.2  2  FixP_N    N-terminal domain of cytochrome oxidase-cbb3, FixP
       0.62    8.8   4.8        1.4    7.7   1.3    2.2  2  DUF2254   Predicted membrane protein (DUF2254)


Domain annotation for each model (and alignments):
>> FixP_N  N-terminal domain of cytochrome oxidase-cbb3, FixP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.2      0.95   8.5e+03      31      43 ..      82      94 ..      80      97 .. 0.68
   2 ?   10.7   0.4   3.8e-05      0.34      24      46 ..     205     227 ..     203     229 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.95
      FixP_N 31 ivfavvYlilYpa 43
                i+++ vYl+++ +
  EFC36225.1 82 IFMGPVYLLFWNL 94
                6677788887655 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 3.8e-05
      FixP_N  24 lylFyativfavvYlilYpalgl 46 
                 l +F+++++f+++Yl ++ ++g+
  EFC36225.1 205 LGMFLGGFIFSFIYLRYFEVNGI 227
                 679***************99986 PP

>> DUF2254  Predicted membrane protein (DUF2254)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1     0.007        63      18      62 ..      30      64 ..      18      66 .. 0.73
   2 ?    7.7   1.3   0.00016       1.4      93     123 ..     202     228 ..     194     254 .. 0.68

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.007
     DUF2254 18 lalllllldealslsldleelkegaeaaralLstiagsmltvagf 62
                l  ++++ld++          k+++ +  alL ti+gs+ t++g+
  EFC36225.1 30 LQQAMVWLDAD----------KDSSRDFVALLITIVGSVATLIGL 64
                44555555544..........3388999999*******9999986 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00016
     DUF2254  93 qvvLGtfigtfvYsllvlrairteeevpqls 123
                    LG+f+g+f++s + lr ++    v++++
  EFC36225.1 202 VGSLGMFLGGFIFSFIYLRYFE----VNGIL 228
                 568****************999....44433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.55
# Mc/sec: 1567.26
//
Query:       EFC36226.1  [L=2154]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      4e-09   36.8   0.5    9.7e-09   35.5   0.5    1.7  1  RGS              Regulator of G protein signaling domain
    2.5e-05   24.0   0.1    6.1e-05   22.7   0.1    1.6  1  Guanylate_cyc    Adenylate and Guanylate cyclase catalytic do
     0.0018   18.7   1.1     0.0042   17.6   1.1    1.7  1  GPS              GPCR proteolysis site, GPS, motif
  ------ inclusion threshold ------
       0.19   11.2   0.0       0.42   10.1   0.0    1.5  1  CENP-F_C_Rb_bdg  Rb-binding domain of kinetochore protein Cen
        2.7    8.2   5.4        3.5    7.8   0.6    3.0  2  DUF2371          Uncharacterised conserved protein (DUF2371)


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.5   0.5   2.7e-12   9.7e-09       3     116 ..    1253    1365 ..    1251    1367 .. 0.84

  Alignments for each domain:
  == domain 1  score: 35.5 bits;  conditional E-value: 2.7e-12
                  HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS...STTTTTTHHHHHH CS
         RGS    3 eslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke...qpsrklfeeaqee 96  
                   +ll+d+ g +lF++F+ +efs enl+ + ++ e++++   ++l+k++ +  ++yl+ ssp e+ni++ +r+   + +ek+   ++  ++++ +++ 
  EFC36226.1 1253 VELLSDELGAKLFENFCTKEFSLENLKCYNEILELNTS---SNLIKDCSAFRDKYLSASSPLEVNIPNPTRKLFISLFEKQasqSEFLTALDTLKSD 1346
                  689*********************************99...99*******************************99999954444444455555555 PP

                  HHHHHHHHHHHHHHTSHHHH CS
         RGS   97 vfellekdsypkFlkselyl 116 
                  +   l +d y++F  s+ y+
  EFC36226.1 1347 IVLNL-SDTYSRFGVSKDYT 1365
                  55555.57888888877775 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.1   1.7e-08   6.1e-05      22     166 ..    1888    2035 ..    1883    2048 .. 0.77

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 1.7e-08
  Guanylate_cyc   22 lssahspievvklLnelyarfdelldekk.vykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskeglkvrvGihtGpvvag 114 
                     +s++ + ++v +l +++++ +  ++++ +   +v t+ d y +++     +++    ++e aL++ + ++++++ s+ +++  +G+++G+  +g
     EFC36226.1 1888 YSKELNSVDVGNLFAKIISGMTVIAKNIQgDLQVITV-DDYQIYVSDGIGRKSSNILALEAALKLRKLISTINKTSQSHIQCSIGVSSGKSNSG 1980
                     5666677778888888888888888887734556666.445555555556777778899*********************************** PP

  Guanylate_cyc  115 viGakkpr.ydvwGntvnlAsrmestgkagkiqv..seetyellkeeqfelterg 166 
                      +G+  +r +++ Gn +  A ++  ++ + ++++   e+t +  ++++f ++ ++
     EFC36226.1 1981 NLGTHSFRiFTIVGNVPSNAEKLSLLASSLHCNIvcDESTLNENTKHHFVYRPVD 2035
                     ***6665549*******************99999544555554446666666555 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   1.1   1.2e-06    0.0042       2      44 ..     818     864 ..     817     865 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.2e-06
         GPS   2 sCvfWdeeneetgsWsteGCel.......tesdnknetvCsCnHLtsFAv 44 
                 +C +W   ne+ ++W t+GC++       ++++   ++  +  H+t FAv
  EFC36226.1 818 TCRYW---NETVSDWRTNGCTVssystkdVNGTIYYSINMKAYHTTQFAV 864
                 8****...6788********998888887677677888899999999998 PP

>> CENP-F_C_Rb_bdg  Rb-binding domain of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   0.00012      0.42      17      37 ..     408     429 ..     401     435 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00012
  CENP-F_C_Rb_bdg  17 evV.qkGFADIPsgeasPYilR 37 
                      +vV + G ADIP  e s Y++ 
       EFC36226.1 408 DVViKSGMADIPNSELSQYVVQ 429
                      555166**************96 PP

>> DUF2371  Uncharacterised conserved protein (DUF2371)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.4      0.14   4.9e+02      41      68 ..     891     918 ..     883     941 .. 0.85
   2 ?    7.8   0.6   0.00099       3.5      27     105 ..    1720    1810 ..    1712    1819 .. 0.60

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.14
     DUF2371  41 glvlllGllvllvGiamavlgywpkkak 68 
                 g+ + +G+++ +v ++m +l + +++++
  EFC36226.1 891 GFQIGIGFIICIVSLVMLILLFIYRNQQ 918
                 888999*************999988854 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00099
     DUF2371   27 vvvvkGklkLlsv..sglvlllGllvllvGiamavlgywpkk..........aklaseekssssstaessseklgllarfleqylysdklk 105 
                  vvv k  ++L+s   sg+ + + +l+++ G+ m++l     +          +k+++ e ++ + + ++ se  ++ + + e  ++ +++k
  EFC36226.1 1720 VVVEKKEIELVSNitSGVSVGITILIIIFGVIMSILISHTVThpftilekefRKIKTMELENVNISGSKFSEVDTIYMYLYEMTVWLNEIK 1810
                  6777889*****62266666666778889*****997766665666665554333333333333333333333444555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1620  (0.0903564); expected 358.6 (0.02)
Passed bias filter:                      555  (0.0309554); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.30u 0.37s 00:00:01.67 Elapsed: 00:00:00.56
# Mc/sec: 11481.51
//
Query:       EFC36227.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.9e-09   35.7   0.1    1.2e-06   28.1   0.1    2.2  2  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
      0.015   14.6   0.1       0.27   10.5   0.0    2.3  2  Pkinase_Tyr  Protein tyrosine kinase
      0.022   15.0   0.4       0.47   10.8   0.1    2.4  2  KAR          Kidney androgen-regulated
       0.05   12.9   0.0      0.074   12.4   0.0    1.3  1  Kinase-like  Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.1   0.1   2.7e-10   1.2e-06      94     194 ..     130     233 ..      79     239 .. 0.75
   2 !    6.0   0.0    0.0014       6.5     231     258 ..     237     264 ..     231     267 .. 0.82

  Alignments for each domain:
  == domain 1  score: 28.1 bits;  conditional E-value: 2.7e-10
                 S--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH...TTSCBSHHHHHHHHHH CS
     Pkinase  94 slseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge....lKitDFGlakelessskltsfvgtseYlAPEvl...keneyskkvDvWslGv 185
                 + s++ + +++ q+++g++ lH++g++Hr + p  i i +++e    +K++    ++++      +++   se  APE+    +e +y ++ D++slG+
  EFC36227.1 130 NESDQILLEWVLQLIKGVKSLHEQGFVHRNIIPFHIHIYSDEEgkyfVKLGGTWSSCQIGY----KEEPYNSEIKAPEIRigdEEFDYLPSLDIYSLGI 224
                 23455667999*************************9986666669999996666666665....4566777889***9778777899*********** PP

                 HHHHHHHSS CS
     Pkinase 186 ilyelltgk 194
                 ++ ++l + 
  EFC36227.1 225 TISQILERV 233
                 **9999875 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0014
                 TTS-HHHHHHHHHHT-SSGCCSTTHHHH CS
     Pkinase 231 seiseeakdllkkllkkdpkkRltaeel 258
                 ++i + + ++++++ ++dp++R+t++++
  EFC36227.1 237 DSILSLVNSFIDQMTSEDPEQRPTIDDC 264
                 556667889***************9876 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   5.9e-05      0.27      87     130 ..     116     161 ..     101     236 .. 0.82
   2 ?    1.5   0.0     0.033   1.5e+02     224     255 ..     233     264 ..     226     268 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 5.9e-05
                  BHHHHHHHTCTTTSBHHH..HHHHHHHHHHHHHHHHHTTEEEST-S CS
  Pkinase_Tyr  87 dLlkfLrkkekekltlkd..llsfalqvAkGmeyLeskklvHrdla 130
                  +Ll+fL+ ++  +++ +d  ll+++lq+ kG++ L+++ +vHr++ 
   EFC36227.1 116 SLLEFLNGEKVIHCNESDqiLLEWVLQLIKGVKSLHEQGFVHRNII 161
                  677888877555555544348999*******************985 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.033
                  S-BBTTSBHHHHHHHHHHT-SSGGGS--HHHH CS
  Pkinase_Tyr 224 lekpekcpeelyelmkkcweedpeeRptfsel 255
                  ++  +++ + +++++ +  +edpe+Rpt+ ++
   EFC36227.1 233 VKVSDSILSLVNSFIDQMTSEDPEQRPTIDDC 264
                  555566667788999999**********9987 PP

>> KAR  Kidney androgen-regulated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.063   2.8e+02      41      61 ..      32      52 ..       7      62 .. 0.81
   2 ?   10.8   0.1    0.0001      0.47      13      40 ..     235     262 ..     215     265 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.063
         KAR 41 stddelstdseqimdttyaks 61
                st +e +td e +m   ++ +
  EFC36227.1 32 STVKEKNTDKEFFMYSFQSGN 52
                7999*******9997766655 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.0001
         KAR  13 lqdsiidllnsvsdqlasyegskapled 40 
                 + dsi+ l+ns  dq++s ++ + p  d
  EFC36227.1 235 VSDSILSLVNSFIDQMTSEDPEQRPTID 262
                 679******************9999866 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.7e-05     0.074     131     199 ..     121     193 ..      91     244 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.7e-05
  Kinase-like 131 lqkrsethkkletiarlllTlqlirlaanLqakglvhgkftvdn..llldekgg..lmlggftaLvragtkvv 199
                  l+ +++ h ++ +   l   lqli+ + +L+++g vh ++ + +  ++ de+g+  ++lgg+ +  + g k  
   EFC36227.1 121 LNGEKVIHCNESDQILLEWVLQLIKGVKSLHEQGFVHRNIIPFHihIYSDEEGKyfVKLGGTWSSCQIGYKEE 193
                  555555555555555555568********************97621577888874456788777666666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       520  (0.0290033); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1676.90
//
Query:       EFC36228.1  [L=459]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2833.10
//
Query:       EFC36229.1  [L=303]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.068   13.3   0.2       0.28   11.3   0.1    2.2  2  DUF3420   Domain of unknown function (DUF3420)


Domain annotation for each model (and alignments):
>> DUF3420  Domain of unknown function (DUF3420)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   1.6e-05      0.28       8      22 ..     194     208 ..     190     219 .. 0.90
   2 ?   -3.4   0.0      0.65   1.2e+04      35      44 ..     284     296 ..     277     296 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.6e-05
     DUF3420   8 EKeLPievlakIkel 22 
                 +K+LPie+l  Ike+
  EFC36229.1 194 AKSLPIELLSHIKEF 208
                 8************98 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.65
     DUF3420  35 l...ddleekrir 44 
                 +   + ++ kr+r
  EFC36229.1 284 KvfiKNFSKKRTR 296
                 2555788999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (303 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1965.09
//
Query:       EFC36230.1  [L=131]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-06   28.3   3.0    1.9e-06   27.9   3.0    1.2  1  Apolipoprotein   Apolipoprotein A1/A4/E domain
    6.5e-06   26.2   5.5    0.00027   21.0   0.8    1.9  2  Baculo_PEP_C     Baculovirus polyhedron envelope protein, PEP
    2.9e-05   23.2   9.7    3.2e-05   23.0   9.7    1.1  1  Mitofilin        Mitochondrial inner membrane protein
     0.0002   21.3   7.6    0.00031   20.7   7.6    1.3  1  PIN_8            PIN like domain
    0.00063   20.0  11.8      0.099   12.9   5.2    2.7  2  Aha1_N           Activator of Hsp90 ATPase, N-terminal
     0.0021   18.1  16.9      0.018   15.1  16.9    2.1  1  DUF1640          Protein of unknown function (DUF1640)
     0.0023   17.1   5.6     0.0029   16.8   5.6    1.2  1  dCache_2         Cache domain
      0.005   16.2   5.5     0.0075   15.7   5.5    1.3  1  DUF4407          Domain of unknown function (DUF4407)
     0.0053   17.3  13.4       0.12   12.9   8.3    2.3  2  YtxH             YtxH-like protein
     0.0054   17.8   9.0      0.039   15.0   0.9    2.7  2  RNase_J_C        Ribonuclease J C-terminal domain
     0.0055   16.8   4.3      0.093   12.8   1.6    2.1  2  ATP-synt_B       ATP synthase B/B' CF(0)
     0.0086   14.1   9.0       0.01   13.9   9.0    1.1  1  Prominin         Prominin
  ------ inclusion threshold ------
      0.013   15.0  10.1      0.073   12.6   6.8    2.1  2  Fzo_mitofusin    fzo-like conserved region
      0.015   15.7   7.6       0.16   12.5   1.0    2.3  2  HTH_40           Helix-turn-helix domain
      0.017   14.9   8.2       0.43   10.4   0.3    2.9  3  Brr6_like_C_C    Di-sulfide bridge nucleocytoplasmic transpor
      0.017   14.9   7.6      0.021   14.7   7.6    1.1  1  DUF445           Protein of unknown function (DUF445)
      0.018   15.1  10.1        2.4    8.2   0.7    3.2  3  Bcr-Abl_Oligo    Bcr-Abl oncoprotein oligomerisation domain
       0.02   14.5  10.4      0.049   13.3  10.5    1.6  1  Mt_ATP-synt_B    Mitochondrial ATP synthase B chain precursor
       0.02   15.2   8.3          2    8.8   2.6    3.3  3  MbeB_N           MbeB-like, N-term conserved region
       0.02   14.4   4.6      0.023   14.3   4.6    1.1  1  Exonuc_VII_L     Exonuclease VII, large subunit
      0.022   14.3   6.5       0.04   13.4   6.5    1.5  1  Z1               Z1 domain
      0.025   14.6   7.6      0.093   12.8   7.8    1.8  1  DUF1664          Protein of unknown function (DUF1664)
      0.032   14.7  13.3       0.11   13.0   7.2    2.9  2  HSCB_C           HSCB C-terminal oligomerisation domain
      0.035   14.2  21.8        0.4   10.8  20.5    2.2  1  PKK              Polo kinase kinase
       0.04   14.5   7.3        0.4   11.3   3.8    2.3  2  Syntaxin-6_N     Syntaxin 6, N-terminal
      0.042   13.8  13.3       0.57   10.1   0.8    2.4  3  Phage_Mu_Gam     Bacteriophage Mu Gam like protein
      0.043   12.4   5.1      0.049   12.2   5.1    1.1  1  Peptidase_M2     Angiotensin-converting enzyme
      0.044   14.3   7.6      0.058   13.9   7.6    1.1  1  DUF2115          Uncharacterized protein conserved in archaea
       0.05   14.2   3.7       0.55   10.9   1.9    2.0  2  DUF883           Bacterial protein of unknown function (DUF88
      0.052   14.0   1.9        5.5    7.5   0.1    2.4  2  DUF668           Protein of unknown function (DUF668)
      0.054   13.8   7.0       0.55   10.6   0.3    2.9  3  DUF4854          Domain of unknown function (DUF4854)
       0.07   13.0  10.3       0.19   11.5  10.3    1.7  1  Bacillus_HBL     Bacillus haemolytic enterotoxin (HBL)
      0.078   12.9   3.3       0.36   10.7   0.5    2.1  2  5_3_exonuc_N     5'-3' exonuclease, N-terminal resolvase-like
       0.08   13.3   2.0       0.26   11.7   2.0    1.8  1  DUF5063          Domain of unknown function (DUF5063)
      0.085   12.6  13.4      0.044   13.6   4.0    2.2  2  DUF1837          Domain of unknown function (DUF1837)
      0.086   12.8   3.6       0.56   10.2   3.8    2.4  1  Band_7           SPFH domain / Band 7 family
      0.089   13.0   7.4        1.7    8.8   1.0    2.7  2  GreA_GreB_N      Transcription elongation factor, N-terminal
      0.097   12.4   5.7        0.1   12.4   5.7    1.1  1  AAA_11           AAA domain
       0.11   12.7  17.4         12    6.1   1.0    4.4  3  YojJ             Bacterial membrane-spanning protein N-termin
       0.12   12.7  10.8       0.27   11.5  10.8    1.7  1  THOC7            Tho complex subunit 7
       0.13   11.5   6.4       0.18   11.1   5.3    1.6  2  ATPase           KaiC
       0.17   10.6  13.8       0.19   10.4  13.8    1.1  1  HlyD_2           HlyD family secretion protein
       0.17   10.1   7.9       0.19    9.9   7.9    1.1  1  HSP70            Hsp70 protein
       0.17   12.2   1.7       0.46   10.8   0.3    2.0  2  DUF1269          Protein of unknown function (DUF1269)
       0.19   12.0  10.3        4.2    7.7  10.2    2.1  2  RGS              Regulator of G protein signaling domain
       0.21   11.5  12.9        1.1    9.1  12.9    2.1  1  RRF              Ribosome recycling factor
       0.21   11.4  15.8        3.6    7.4   1.7    2.8  2  SICA_alpha       SICA extracellular alpha domain
       0.21   11.7   6.4       0.27   11.4   6.4    1.2  1  DUF4337          Domain of unknown function (DUF4337)
       0.22   10.9  14.3       0.27   10.6  14.2    1.2  1  IMD              IRSp53/MIM homology domain
       0.23   12.0   3.6        2.5    8.6   0.5    2.2  2  PSD4             Protein of unknown function (DUF1592)
       0.24   10.7   9.1       0.36   10.1   1.6    2.0  2  P35              Apoptosis preventing protein
       0.25   11.4   0.8        1.1    9.4   0.7    2.0  1  PilJ             Type IV pili methyl-accepting chemotaxis tra
       0.26   11.4   2.2        1.5    8.9   0.4    2.5  3  SpoIIID          Stage III sporulation protein D
       0.27   11.7  14.5          3    8.3   6.0    2.0  2  Nop25            Nucleolar protein 12 (25kDa)
       0.32   11.1  10.5        3.5    7.8   1.4    3.8  3  Annexin          Annexin
       0.36   11.6   3.6         11    6.9   0.5    2.3  2  HYLS1_C          Hydrolethalus syndrome protein 1 C-terminus
       0.37   11.6   7.5          4    8.3   2.0    2.4  2  FliT             Flagellar protein FliT
        0.4   10.7   7.4        5.2    7.2   0.2    3.1  2  SASP             Small, acid-soluble spore proteins, alpha/be
        0.4   10.0   5.5        1.9    7.8   1.4    2.2  2  ZnuA             Zinc-uptake complex component A periplasmic
       0.41   11.0  12.2        1.5    9.2  11.8    2.4  1  V-SNARE          Vesicle transport v-SNARE protein N-terminus
       0.46   11.0   8.1        8.8    6.9   0.6    2.7  2  CCDC74_C         Coiled coil protein 74, C terminal
       0.47   10.4   7.4          2    8.4   0.3    2.3  2  Focal_AT         Focal adhesion targeting region
        0.5   10.6   4.9         13    6.1   0.2    2.8  3  T3SS_needle_F    Type III secretion needle MxiH, YscF, SsaG, 
        0.5   10.4   8.1       0.84    9.7   8.1    1.4  1  7TMR-HDED        7TM-HD extracellular
       0.58   10.8   7.1        3.9    8.1   0.8    2.3  2  DUF3502          Domain of unknown function (DUF3502)
       0.65   10.1   9.0       0.99    9.5   0.9    3.2  3  DUF3763          Protein of unknown function (DUF3763)
       0.65    9.8   8.8       0.39   10.5   4.5    1.9  2  RB_A             Retinoblastoma-associated protein A domain
       0.78    9.3   9.0       0.91    9.0   9.0    1.1  1  Cas_DxTHG        CRISPR-associated (Cas) DxTHG family
       0.81    9.9   7.0        1.2    9.4   2.8    2.0  2  CsgF             Type VIII secretion system (T8SS), CsgF prot
       0.87    8.1  10.9          1    7.9  10.9    1.1  1  FapA             Flagellar Assembly Protein A
          1    8.6   9.4        1.3    8.2   9.4    1.2  1  TMPIT            TMPIT-like protein
        1.1    9.6   6.3         27    5.1   0.2    3.3  3  PHA_gran_rgn     Putative polyhydroxyalkanoic acid system pro
        1.3    9.4   8.2         58    4.0   7.7    3.0  1  DUF1722          Protein of unknown function (DUF1722)
        1.3    9.5   9.8        6.1    7.4   2.5    2.3  2  PNPase           Polyribonucleotide nucleotidyltransferase, R
        1.6    8.7   9.8        7.1    6.6   9.8    1.9  1  ResIII           Type III restriction enzyme, res subunit
        1.7    8.9  17.5        2.5    8.5  17.2    1.4  1  OmpH             Outer membrane protein (OmpH-like)
        2.1    7.6   8.5         35    3.6   7.9    2.4  2  EAP30            EAP30/Vps36 family
        2.2    8.6   9.1        1.2    9.4   0.8    3.2  2  TA0956           Thermoplasma acidophilum protein TA0956
        2.2    8.7   8.0        2.6    8.4   2.8    2.3  2  Bac_RepA_C       Replication initiator protein A C-terminal d
        2.3    9.2  14.3    9.5e+02    0.9  14.3    2.4  1  PdaC             Deacetylase PdaC
        2.4    7.4   5.4        4.3    6.6   1.7    2.0  2  DUF3810          Protein of unknown function (DUF3810)
        2.4    8.7  16.9       0.45   11.0   1.0    2.5  2  DUF16            Protein of unknown function DUF16
        2.6    8.5   7.9        3.4    8.2   4.5    1.9  2  Spore_II_R       Stage II sporulation protein R (spore_II_R)
        2.7    7.8  11.9        5.1    6.9  11.9    1.5  1  AbiH             Bacteriophage abortive infection AbiH
        3.2    8.2  10.3        9.9    6.6  10.4    1.8  1  CelTOS           Cell-traversal protein for ookinetes and spo
        3.8    6.5  11.2        4.4    6.3  11.2    1.0  1  eIF-4B           Plant specific eukaryotic initiation factor 
        4.2    8.0  12.0      3e+03   -1.2  12.0    2.8  0  Pet100           Pet100
        4.4    7.8   6.0         12    6.4   0.8    2.2  2  OTU              OTU-like cysteine protease
        4.6    7.8   8.1      4e+02    1.6   8.1    2.6  1  Arc_PepC_II      Archaeal Peptidase A24 C-terminus Type II
        4.9    7.9  14.3         15    6.3   2.8    2.8  2  AKNA             AT-hook-containing transcription factor
          5    7.5  11.5    1.2e+03   -0.1  11.4    3.2  1  Dynein_light     Dynein light chain type 1
          6    5.9  11.7        4.3    6.3   1.4    1.9  2  Toxin_trans      Clostridium neurotoxin, Translocation domain
        8.6    6.0  30.9       0.19   11.3   1.3    5.0  4  VASP_tetra       VASP tetramerisation domain
        9.5    6.6  13.2        3.7    8.0   5.5    2.3  2  Uteroglobin      Uteroglobin family


Domain annotation for each model (and alignments):
>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   3.0   9.7e-09   1.9e-06      99     183 ..      21     103 ..       9     126 .. 0.55

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 9.7e-09
                     CHCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH-----..-----SSSHHH.HHHHTS-TTSHHHHHS--XXXXXXXX CS
  Apolipoprotein  99 vyaeelrerlerhvealkarlapyveelrqklaerleelkeslaphaeeveerlssrve.elrekleeqaeelrerleanleelka 183
                     v +e++++ +++++e+ k+ l     e++++l+e+l+elk+ ++++ e++++ l+s+++ el+e+l+e  ++++++ e  + ++k+
      EFC36230.1  21 VFQENIKKDIKQELEKFKSDLR---SEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKnELKEQLDEFKQDMKQEFEMCKNDIKD 103
                     4445555555555555554443...5555555555555555555555555555555553255555555555555555444444443 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.3   0.00024     0.045      49      94 ..      25      71 ..       2      77 .. 0.62
   2 !   21.0   0.8   1.4e-06   0.00027      24     112 ..      29     119 ..      23     125 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 0.00024
  Baculo_PEP_C 49 alsedlksllaeldtrldt.lltnLtdalnalqdtlrneLtnlnsil 94
                  ++++d+k+ l++++++l +   ++L+++l +l++++++e +  +s+l
    EFC36230.1 25 NIKKDIKQELEKFKSDLRSeIKNELKEQLDELKQDIKQEFEKFKSDL 71
                  45666666666666666541334566666666666666666666655 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 1.4e-06
  Baculo_PEP_C  24 airlqnvqilaqlat.lldaietqLnalsedlksllaeldtrldt.lltnLtdalnalqdtlrneLtnlnsiltnLlssvtNinstLnnll 112
                   +i+  + +  ++l + +++++++qL++l++d+k+  ++++++l +   ++L+++l ++++++++e +  ++++ + l +vt  + tL  ll
    EFC36230.1  29 DIKQELEKFKSDLRSeIKNELKEQLDELKQDIKQEFEKFKSDLRSeIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTKNICTLYELL 119
                   666666666777754167889********************998615577*******************9999999999998888888877 PP

>> Mitofilin  Mitochondrial inner membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   9.7   1.7e-07   3.2e-05     304     384 ..      11      92 ..       6     120 .. 0.83

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 1.7e-07
   Mitofilin 304 lskelaelkkeeekkieralekqkee.lekqeealsarleeerakeerqlrlelereleeireeyeekLrteLerqaeahee 384
                 l+ke++++ +  +++i++ +++  e+ +++++++++ +l+e++++ ++++++e+e+    +r+e +++L+++L++ ++++++
  EFC36230.1  11 LKKEMQTMFVVFQENIKKDIKQELEKfKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQ 92 
                 5677777777777788888888777777899999999999999999999999999999999999999999999988887766 PP

>> PIN_8  PIN like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   7.6   1.6e-06   0.00031      48     143 ..      23     121 ..       3     129 .. 0.69

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 1.6e-06
       PIN_8  48 resviskekkayedlekel.eklkkaaekkleealkkwakkkald.....teelrkelkkqleelkeelkaeleelkksskadkeedpilkkleelleg 140
                 +e++ ++ k+ +e+++++l +++k++++++l+e lk++ k++  +     ++e+++elk+ql+e+k+++k+e e++k+++k+d    ++ k++++l+e 
  EFC36230.1  23 QENIKKDIKQELEKFKSDLrSEIKNELKEQLDE-LKQDIKQEFEKfksdlRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDL--GKVTKNICTLYEL 118
                 445555555666666666655555555544443.3333333222233557999*****************************98..8999999999875 PP

       PIN_8 141 kig 143
                   +
  EFC36230.1 119 LLT 121
                 555 PP

>> Aha1_N  Activator of Hsp90 ATPase, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   4.4    0.0032      0.61      93     137 .]      21      64 ..       2      64 .. 0.78
   2 !   12.9   5.2   0.00052     0.099     101     137 .]      58      94 ..      44      94 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.0032
      Aha1_N  93 eievsvkkdeekkekqklkelikskgvpklreklakfvkeLkeeh 137
                 +++ ++kk + k+e +k k+ ++s+++++l+e+l+++++++k+e+
  EFC36230.1  21 VFQENIKK-DIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEF 64 
                 45555666.467788899**********************99886 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 0.00052
      Aha1_N 101 deekkekqklkelikskgvpklreklakfvkeLkeeh 137
                 ++ k+e +k k+ ++s+++++l+e+l++f++++k+e+
  EFC36230.1  58 QDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEF 94 
                 346778999************************9986 PP

>> DUF1640  Protein of unknown function (DUF1640)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1  16.9   9.4e-05     0.018      48     136 ..      23     109 ..       2     126 .. 0.47

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 9.4e-05
     DUF1640  48 lekseylqkaalselrkevqisersefa.alrseteklqreleklkqkLreeidklkadirldlnleKgrireelakleakiqelnnkid 136
                 +e++   +k +l+++++++++  ++e + +l + ++ +++e+ek k++Lr+ei++  ++   +l++ K+++++e+++ ++ i++   k++
  EFC36230.1  23 QENIKKDIKQELEKFKSDLRSEIKNELKeQLDELKQDIKQEFEKFKSDLRSEIKNELKE---QLDEFKQDMKQEFEMCKNDIKDDLGKVT 109
                 34444444444444444444444444321333334444444444444444444332222...3444444444444444444444333333 PP

>> dCache_2  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   5.6   1.5e-05    0.0029       2      70 ..      27      99 ..      26     123 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.5e-05
    dCache_2  2 ksdfkeeiekleeetikerkellksevdsaielie....yeknsleeslkesLksrveeaysiaeeiyekykn 70
                k+d+k+e+ek++ +   e k++lk++ d++++ i+    + k++l++++k++Lk++ +e+ + +++  e  kn
  EFC36230.1 27 KKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKqefeKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKN 99
                6899*******************************99888888899999999999999987666665555555 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   5.5   3.9e-05    0.0075     100     177 ..      18     103 ..      16     123 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3.9e-05
     DUF4407 100 eLkiFekeIdaelaeeqqeeakelkeqlaaaltaelaeleaqia........alqaeid.aaearldalraeaqkeldgtkgtgttg 177
                 ++++F++ I++ +++e ++ +++l+++++++l+++l+el+++i+        +l++ei+ +++++ld+ ++++++e +  +++ ++ 
  EFC36230.1  18 MFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKqefekfksDLRSEIKnELKEQLDEFKQDMKQEFEM-CKNDIKD 103
                 6899****************************************88888888555555313444555555555555443.4444444 PP

>> YtxH  YtxH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   5.5   0.00078      0.15      25      74 ..      25      71 ..      13      72 .. 0.87
   2 !   12.9   8.3   0.00062      0.12      25      73 ..      44     100 ..      43     117 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00078
        YtxH 25 etRkdlkekaddlkekakelleeakekakekaedlkekvkekadelkekv 74
                + +kd+k++++++k ++     e+k+  ke+ ++lk+++k+++++ k+++
  EFC36230.1 25 NIKKDIKQELEKFKSDL---RSEIKNELKEQLDELKQDIKQEFEKFKSDL 71
                56899999999999998...55567778****************999875 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 0.00062
        YtxH  25 etRkdlkekaddlkekakelleeakeka........kekaedlkekvkekadelkek 73 
                 e +++lke++d+lk+++k+  e++k+          ke+ +++k+++k++++  k++
  EFC36230.1  44 EIKNELKEQLDELKQDIKQEFEKFKSDLrseiknelKEQLDEFKQDMKQEFEMCKND 100
                 788899999999999999998888888887777777777777777777776655555 PP

>> RNase_J_C  Ribonuclease J C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   3.0      0.12        22      20      53 ..      35      65 ..       5      74 .. 0.54
   2 !   15.0   0.9    0.0002     0.039      13      56 ..      66     109 ..      62     113 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.12
   RNase_J_C 20 eeakkvvretieealeekesdwnelkrkirealk 53
                e+ k+ +r+ i++ l+e   + +elk++i+++ +
  EFC36230.1 35 EKFKSDLRSEIKNELKE---QLDELKQDIKQEFE 65
                33333333333333333...45555555555544 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 0.0002
   RNase_J_C  13 keseeLieeakkvvretieealeekesdwnelkrkirealkkfl 56 
                 k + +L +e+k+ ++e ++e++++ + + +  k++i+++l+k+ 
  EFC36230.1  66 KFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVT 109
                 556799**********************************9976 PP

>> ATP-synt_B  ATP synthase B/B' CF(0)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   1.6   0.00049     0.093      81     120 ..      22      61 ..       7      63 .. 0.88
   2 ?    7.7   0.3     0.018       3.5      69     122 ..      55     108 ..      54     114 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 0.00049
  ATP-synt_B  81 lkeeieaeaeaeaerlkesAaaeIeqekdralaeLreqvv 120
                  +e+i+++ ++e+e+ k++ + eI+ e ++ l+eL++++ 
  EFC36230.1  22 FQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIK 61 
                 689**********************************985 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.018
  ATP-synt_B  69 eiiknAkkeaeklkeeieaeaeaeaerlkesAaaeIeqekdralaeLreqvval 122
                 e+ ++ k+e ek k +++ e ++e++ +  + +++ +qe +  +++++++ +++
  EFC36230.1  55 ELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKV 108
                 556666777777777777777777777777777777777777777777666655 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   9.0   5.3e-05      0.01     194     296 ..      13     113 ..       2     127 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 5.3e-05
    Prominin 194 qhidhvlvqny.eelekhvsddLddagkhlgldladtlesnvlpaLaeler.llenlkeakeqLeq..vnklekeLrksgsqLrdglrgvkrdlnqals 288
                 ++++ ++v  + e+++k+++++L++ ++ l ++++++l+++    L+el++ + ++ ++ k  L++   n+l+++L + ++++++ ++  k+d+++ l 
  EFC36230.1  13 KEMQTMFVV-FqENIKKDIKQELEKFKSDLRSEIKNELKEQ----LDELKQdIKQEFEKFKSDLRSeiKNELKEQLDEFKQDMKQEFEMCKNDIKDDLG 106
                 444554444.3035777888888888888888888888877....777764488888888888875324667778888888888888888888888887 PP

    Prominin 289 nlCqseeC 296
                 +  +++ C
  EFC36230.1 107 K-VTKNIC 113
                 7.333666 PP

>> Fzo_mitofusin  fzo-like conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   6.8   0.00038     0.073      76     157 ..      11      88 ..       5      89 .. 0.79
   2 ?    8.4   0.7    0.0073       1.4     103     140 ..      76     114 ..      66     127 .. 0.56

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00038
  Fzo_mitofusin  76 atekLrlivsltsancshqvqqelsstfarlcqqvdetekeleeeikelekeiek.leevqkkakllr.nkaslleseLekfee 157
                    ++++++++  +  +n+++ ++qel++  + l++++   ++el+e+++el+++i++  e+ ++    lr +  ++l+++L++f++
     EFC36230.1  11 LKKEMQTMFVVFQENIKKDIKQELEKFKSDLRSEI---KNELKEQLDELKQDIKQeFEKFKS---DLRsEIKNELKEQLDEFKQ 88 
                    56889999999999****************99875...789************852444444...4551445789999999986 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0073
  Fzo_mitofusin 103 farlcqqvdetekeleeeikelekeie.kleevqkkakl 140
                     ++l++q de ++++++e +  +++i+  l +v+k+  +
     EFC36230.1  76 KNELKEQLDEFKQDMKQEFEMCKNDIKdDLGKVTKNICT 114
                    345555556666666666555555554134444444333 PP

>> HTH_40  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   1.0   0.00083      0.16      31      81 ..       5      54 ..       2      57 .. 0.82
   2 ?    7.4   1.3     0.032         6      52      81 ..      55      84 ..      52     108 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00083
      HTH_40 31 gHLaelieegeeidlerlvseeeekeIeeaiekvgseklkpikealpeevs 81
                +++a++++++    +  +++e+++k I++ +ek++s+  ++ik++l+e+++
  EFC36230.1  5 DYIANCLKKEM-QTMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLD 54
                78999999964.334344599*************************99875 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.032
      HTH_40 52 eeekeIeeaiekvgseklkpikealpeevs 81
                e ++ I++ +ek++s+  ++ik++l+e+++
  EFC36230.1 55 ELKQDIKQEFEKFKSDLRSEIKNELKEQLD 84
                778999999999999999999999999876 PP

>> Brr6_like_C_C  Di-sulfide bridge nucleocytoplasmic transport domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.3    0.0022      0.43      18      48 ..      17      47 ..       6      52 .. 0.89
   2 ?    4.6   0.2      0.13        25      26      47 ..      55      76 ..      49      78 .. 0.90
   3 ?    7.3   0.7      0.02       3.8      25      52 ..      73     100 ..      70     115 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.0022
  Brr6_like_C_C 18 ylvisfvltikkDiekkleekkaellaeiee 48
                   ++++ f   ikkDi+++le+ k++l++ei++
     EFC36230.1 17 TMFVVFQENIKKDIKQELEKFKSDLRSEIKN 47
                   56788999********************985 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.13
  Brr6_like_C_C 26 tikkDiekkleekkaellaeie 47
                    +k+Di++++e+ k++l++ei+
     EFC36230.1 55 ELKQDIKQEFEKFKSDLRSEIK 76
                   689*****************97 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.02
  Brr6_like_C_C  25 ltikkDiekkleekkaellaeieeCkke 52 
                    + ik++++++l+e k+++++e e Ck++
     EFC36230.1  73 SEIKNELKEQLDEFKQDMKQEFEMCKND 100
                    679**********************986 PP

>> DUF445  Protein of unknown function (DUF445)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   7.6   0.00011     0.021     192     316 ..      24     122 ..       3     128 .. 0.48

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 0.00011
      DUF445 192 tsilekvksdpdhllreeedkkvreliadllndpelaakveklkkkklsdlevqeyeea..lwealkdlllkdlneeesllrerisklleklgeklaed 288
                 ++i +                             ++++++ek+k ++ s+++++ +e+   l +++k+ ++k  ++  s++++++++ l+++++ ++++
  EFC36230.1  24 ENIKK-----------------------------DIKQELEKFKSDLRSEIKNELKEQLdeLKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQE 93 
                 22222.............................34455555555555555544444433355555555555555444555555555555555555555 PP

      DUF445 289 .pklreklnkflenaaakvlekyrldisk 316
                  +  ++ ++++l + ++++   y+l +++
  EFC36230.1  94 fEMCKNDIKDDLGKVTKNICTLYELLLTQ 122
                 55555555555555555555555554444 PP

>> Bcr-Abl_Oligo  Bcr-Abl oncoprotein oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.6      0.03       5.7      27      47 ..      28      49 ..      21      56 .. 0.76
   2 ?    4.7   1.4      0.16        30      27      48 ..      58      80 ..      46      87 .. 0.72
   3 ?    8.2   0.7     0.012       2.4      27      42 ..      88     103 ..      77     114 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.03
  Bcr-Abl_Oligo 27 edieqeLerCkaslrr.Lekel 47
                   +di+qeLe+ k +lr  +++el
     EFC36230.1 28 KDIKQELEKFKSDLRSeIKNEL 49
                   79************96244444 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.16
  Bcr-Abl_Oligo 27 edieqeLerCkaslrr.Lekeln 48
                   +di+qe+e+ k +lr  +++el+
     EFC36230.1 58 QDIKQEFEKFKSDLRSeIKNELK 80
                   69***********9962444444 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.012
  Bcr-Abl_Oligo  27 edieqeLerCkaslrr 42 
                    +d++qe+e Ck++++ 
     EFC36230.1  88 QDMKQEFEMCKNDIKD 103
                    69***********995 PP

>> Mt_ATP-synt_B  Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3  10.5   0.00026     0.049      80     162 ..      14     101 ..       8     102 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 0.00026
                    HHHHHHHHHHHH....HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHCT.CCCCHHHHHHHHHHHH CS
  Mt_ATP-synt_B  80 ltkslfevskeq....valeaeaferelqaklareikkkldtlvnaessrrqrlQdelvkgvissVlkels.spkfkkevlqesiadl 162
                    + +++f+v  e+    ++ e+e+f++ l+ ++++e+k+ ld l +  +++ ++ +++l + + +   ++l   ++  k+ ++ + +d+
     EFC36230.1  14 EMQTMFVVFQENikkdIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDeFKQDMKQEFEMCKNDI 101
                    556666665555111167899*************************************************875555566667777776 PP

>> MbeB_N  MbeB-like, N-term conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.3      0.24        46      19      42 ..      23      46 ..      22      48 .. 0.87
   2 ?    8.8   2.6     0.011         2       9      42 ..      43      76 ..      39      80 .. 0.87
   3 ?    6.0   0.0     0.078        15      14      48 ..      78     112 ..      75     114 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.24
      MbeB_N 19 aeSteemvksafekheksvkeaLk 42
                +e + + +k ++ek  +++++++k
  EFC36230.1 23 QENIKKDIKQELEKFKSDLRSEIK 46
                56788999***********99987 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.011
      MbeB_N  9 ktFeqkskeqaeSteemvksafekheksvkeaLk 42
                 +    +keq     + +k +fek  +++++++k
  EFC36230.1 43 SEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIK 76
                5667789***********************9987 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.078
      MbeB_N  14 kskeqaeSteemvksafekheksvkeaLkesekki 48 
                  +keq     +  k +fe   +++k  L +  k+i
  EFC36230.1  78 ELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTKNI 112
                 57999999999999999999999999999888887 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   4.6   0.00012     0.023     153     232 ..      23     101 ..       2     129 .. 0.41

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 0.00012
  Exonuc_VII_L 153 errlekaikrlleekkqrle.klasrlk.speellerkrqrldeleerleralkkqlkkkrerleelkerlkekleekkerl 232
                   +++++k ik+ le+ k+ l+ +++++lk + +el ++ +q++++++++l++++k++lk   e+l+e+k+ +k+++e  k+++
    EFC36230.1  23 QENIKKDIKQELEKFKSDLRsEIKNELKeQLDELKQDIKQEFEKFKSDLRSEIKNELK---EQLDEFKQDMKQEFEMCKNDI 101
                   3444444444444444443312244444222222222244444444444444443332...222223322222222222222 PP

>> Z1  Z1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   6.5   0.00021      0.04      33      89 ..      17      91 ..      13     127 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 0.00021
          Z1 33 srfkdeqekvaelieelleelkkelkesaeekkeellkeleklwekekts..................tkseeee 89
                ++f+  qe+++++i++ le++k++l+++ +++ +e l+el++  ++e ++                  + +++++
  EFC36230.1 17 TMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKfksdlrseiknelkeqldEFKQDMK 91
                567778999999999999999999999988888888888888888883332344444444444444442222222 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   7.8   0.00049     0.093      41     111 ..      25      98 ..      12     111 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 0.00049
     DUF1664  41 davesvskqleqvseslaa.tkrhLssridrvdkklde.qkeiskeikeevt.evredlseigedvesvkeave 111
                 +  +++ ++le+++++l++  k++L++++d++ + +++  ++ ++++++e++ e++e+l+e+++d+++  e+ +
  EFC36230.1  25 NIKKDIKQELEKFKSDLRSeIKNELKEQLDELKQDIKQeFEKFKSDLRSEIKnELKEQLDEFKQDMKQEFEMCK 98 
                 45578999********98527************9997615667889999995389***********99777764 PP

>> HSCB_C  HSCB C-terminal oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   6.6     0.029       5.5      15      57 ..      33      66 ..       7      77 .. 0.61
   2 ?   13.0   7.2   0.00059      0.11      11      56 ..      48      91 ..      48     123 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.029
                HHHCGGGSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHH CS
      HSCB_C 15 eleeaeeaadkeeleelkaeveerieeleaeleeafekkdlea 57
                ele +    + +  +e+k+e++e+++el + ++++f     e+
  EFC36230.1 33 ELEKF----KSDLRSEIKNELKEQLDELKQDIKQEF-----EK 66
                44444....114444555555555555555555555.....22 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 0.00059
                HHHHHHHCGGGSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HH CS
      HSCB_C 11 elrEeleeaeeaadkeeleelkaeveerieeleaeleeafekkdle 56
                el+E+l+e++++  k+e e++k++++++i+++++e  ++f k+d++
  EFC36230.1 48 ELKEQLDELKQD-IKQEFEKFKSDLRSEIKNELKEQLDEF-KQDMK 91
                899******655.66***************9999999999.55655 PP

>> PKK  Polo kinase kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8  20.5    0.0021       0.4      55     134 ..      25     103 ..      23     117 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0021
         PKK  55 riraEqkkelakFkesLkqekke.lkqevreklkkfqrkeklrqkkeeleqeqkeeeleflqkqqealereleqlqnekkk 134
                 +i+++ k+el kFk  L+ e k+ lk++  ++lk++ ++e  +  k  l+ e k+e +e+l++ ++++ +e e+ +n+ k 
  EFC36230.1  25 NIKKDIKQELEKFKSDLRSEIKNeLKEQL-DELKQDIKQEFEK-FKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKD 103
                 56667777777777777776665233333.5555544444333.3344555555666666666666666666666665554 PP

>> Syntaxin-6_N  Syntaxin 6, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   3.8    0.0021       0.4      30      78 ..      25      71 ..       7      78 .. 0.73
   2 ?    7.0   0.4     0.045       8.6      21      59 ..      64     103 ..      60     119 .. 0.62

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.0021
  Syntaxin-6_N 30 dtssstseeldetrteLrkalr.siewdledLeetvriveknpskfkide 78
                  + +++ ++el++ +++Lr++++ +++++l++L++ +   +++ +kfk d 
    EFC36230.1 25 NIKKDIKQELEKFKSDLRSEIKnELKEQLDELKQDI---KQEFEKFKSDL 71
                  223357899999999999998637999999999999...88888888875 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.045
  Syntaxin-6_N  21 yrrwe.rlledtssstseeldetrteLrkalrsiewdled 59 
                   +++++ +l+++ +++ +e+lde +++++++ +  ++d++d
    EFC36230.1  64 FEKFKsDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKD 103
                   4444324444444455666777777777776666666654 PP

>> Phage_Mu_Gam  Bacteriophage Mu Gam like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   6.6     0.018       3.5      19      66 ..      24      72 ..      21      77 .. 0.78
   2 ?    9.1   7.8    0.0061       1.2      13      56 ..      48      92 ..      44     100 .. 0.89
   3 ?   10.1   0.8     0.003      0.57      13      54 ..      78     119 ..      73     129 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.018
                  HHHHHHHHHHHHHHHHHHHHHCH.HHHHHHHHHHHHHHHHHHCTHHHH- CS
  Phage_Mu_Gam 19 eeieaeaneeiaaikekleaele.plkkeieylesllkqYaeankdeLf 66
                  e i++++++e ++ k +l +e++ +lk++ ++l++ +kq +e+ k++L 
    EFC36230.1 24 ENIKKDIKQELEKFKSDLRSEIKnELKEQLDELKQDIKQEFEKFKSDLR 72
                  6788999999999999999998636899999999999988888887775 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0061
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHCH.HHHHHHHHHHHHHHH CS
  Phage_Mu_Gam 13 elkreleeieaeaneeiaaikekleaele.plkkeieylesllkq 56
                  elk++l+e+++++++e ++ k +l +e++ +lk++ +++++ +kq
    EFC36230.1 48 ELKEQLDELKQDIKQEFEKFKSDLRSEIKnELKEQLDEFKQDMKQ 92
                  89*************************96379999****999987 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.003
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH CS
  Phage_Mu_Gam  13 elkreleeieaeaneeiaaikekleaeleplkkeieylesll 54 
                   elk++l+e+++++++e +  k++ ++ l ++ k+i  l +ll
    EFC36230.1  78 ELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTKNICTLYELL 119
                   899999999999999999999999999999999887776655 PP

>> Peptidase_M2  Angiotensin-converting enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   5.1   0.00026     0.049      39     122 ..      22     107 ..       6     129 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00026
                   HHHHHHHHHHHHHHHHHHHHHHHHCCCTGGGSS..-HHHHHHHHHHT--GGGGS-HHHHHHHHHHHHHHHHHHHH-EEE-SSTTSS CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M2  39 enkqakveaklelaefekevakeakkfdlksfq..dedlkrelkklaslgssalseekleeleevlsemekiyskakvcekkkeke 122
                    ++++k + k+el++f++++++e+k+   +++   ++d+k+e++k +s  +s +++e +e+l+e +++m++ ++  k   k++  +
    EFC36230.1  22 FQENIKKDIKQELEKFKSDLRSEIKNELKEQLDelKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGK 107
                   46677888899999999999999998655555445899999999999999999999999999999999999999877666555444 PP

>> DUF2115  Uncharacterized protein conserved in archaea (DUF2115)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   7.6    0.0003     0.058       6     104 ..       8     108 ..       4     124 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 0.0003
     DUF2115   6 leilkkeaskisieDlmkisarlekeikklpekyrkelseslteylfeaykelkn..krsgdkseykeevideeelkeflemleeqceeekeekeerlr 102
                 +++lkke++++ +   ++i++ +++e++k +++ r+e++++l e+l e  +++k+  ++ +++ + + ++  +e+l+ef + +++++e  k++ +++l 
  EFC36230.1   8 ANCLKKEMQTMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQefEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLG 106
                 6899******9999999*************************************942222223333333344455555655555555554444444444 PP

     DUF2115 103 kl 104
                 k+
  EFC36230.1 107 KV 108
                 44 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   3.9    0.0033      0.63       3      61 ..      26      86 ..      24      92 .. 0.70
   2 ?   10.9   1.9    0.0029      0.55       3      52 ..      41      88 ..      39     117 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0033
      DUF883  3 leael.eslladleellkeaadeageeaeelRerleerlerarerlr.daeeavaerakea 61
                +++++ ++l +   +l +e ++e +e+++el++ +++++e+ ++ lr + +++++e+ +e 
  EFC36230.1 26 IKKDIkQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRsEIKNELKEQLDEF 86
                6777744444445678888899999999999999999999999988724556666666655 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.0029
      DUF883  3 leael.eslladleellkeaadeageeaeelRerleerlerarerlrdaee 52
                l++e+ ++l ++l+el ++ ++e ++  ++lR++++++l++  ++++   +
  EFC36230.1 41 LRSEIkNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFK---Q 88
                56666667777777777777777777777777777666554444433...3 PP

>> DUF668  Protein of unknown function (DUF668)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.3     0.085        16      33      77 ..      15      53 ..       4      70 .. 0.58
   2 ?    7.5   0.1     0.029       5.5      39      76 ..      70     108 ..      61     116 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.085
      DUF668 33 rdeLYqmLpasvrsalrakLrslekkeavdellaaeikeevekiL 77
                 ++++    +++++ +++ L++++++ +      +eik+e+++ L
  EFC36230.1 15 MQTMFVVFQENIKKDIKQELEKFKSDLR------SEIKNELKEQL 53
                4556666667777777777777777633......22222222222 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.029
      DUF668  39 mLpasvrsalrakLrslekkea.vdellaaeikeeveki 76 
                  L ++++++l+++L +++++++ + e+  ++ik+++ k+
  EFC36230.1  70 DLRSEIKNELKEQLDEFKQDMKqEFEMCKNDIKDDLGKV 108
                 57789**************98855577788888888776 PP

>> DUF4854  Domain of unknown function (DUF4854)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1       2.3   4.4e+02      53      82 ..       5      35 ..       2      42 .. 0.67
   2 ?    8.6   0.7     0.012       2.3      44      84 ..      38      78 ..      35      79 .. 0.85
   3 ?   10.6   0.3    0.0029      0.55      44      84 ..      68     109 ..      66     121 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 2.3
     DUF4854 53 dalkealaesldsqastfe.slakqlkkevk 82
                d +++ l+++++ +   f+ ++ k++k+e++
  EFC36230.1  5 DYIANCLKKEMQTMFVVFQeNIKKDIKQELE 35
                5566777788888877776246777777765 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.012
     DUF4854 44 skslddaaldalkealaesldsqastfeslakqlkkevkve 84
                +++l ++  ++lke+l+e  +  ++ fe++ ++l +e+k+e
  EFC36230.1 38 KSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNE 78
                5556677788999999999999**************99986 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.0029
     DUF4854  44 skslddaaldalkealaesldsqastfeslakqlkkevkv.e 84 
                 +++l ++  ++lke+l+e  + +++ fe+  +++k+ ++   
  EFC36230.1  68 KSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKvT 109
                 55667778899*************************987643 PP

>> Bacillus_HBL  Bacillus haemolytic enterotoxin (HBL)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  10.3     0.001      0.19      41     130 ..      23     110 ..       6     117 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.001
  Bacillus_HBL  41 nkellsklnqhqklakanak.ewlnevkPqliktiqdiigYstkFqsyyktlveavdkkdkaellellekLqeeiqqnqkevkqlikeLkk 130
                   +++++++++q+++  k + + e  ne+k ql ++ qdi+   ++F++++++l++ ++++ k++l e  +++++e    ++ +k+++++++k
    EFC36230.1  23 QENIKKDIKQELEKFKSDLRsEIKNELKEQLDELKQDIK---QEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTK 110
                   456777778887777777652566778888888888875...5788888888888877777777777777777777777777777776654 PP

>> 5_3_exonuc_N  5'-3' exonuclease, N-terminal resolvase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.5    0.0019      0.36      34      89 ..       4      59 ..       1      65 [. 0.76
   2 ?    3.2   0.2      0.38        73      57      84 ..      68      95 ..      58     104 .. 0.53

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0019
  5_3_exonuc_N 34 lnmllklleeekpthlavvfDakkktfRhelypeYKan.Reetpeelkeqlplikev 89
                  l+ ++++l++e  ++++vvf ++ k+  ++ ++++K++ R+e+++elkeql+ +k+ 
    EFC36230.1  4 LDYIANCLKKEM-QTMFVVFQENIKKDIKQELEKFKSDlRSEIKNELKEQLDELKQD 59
                  567888888777.58999999754344556678899766************999875 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.38
  5_3_exonuc_N 57 kktfRhelypeYKanReetpeelkeqlp 84
                  k+  R+e+ +e K++ +e ++++k++++
    EFC36230.1 68 KSDLRSEIKNELKEQLDEFKQDMKQEFE 95
                  2244555555555555555555555555 PP

>> DUF5063  Domain of unknown function (DUF5063)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   2.0    0.0013      0.26      57     118 ..      54     112 ..       7     128 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.0013
     DUF5063  57 e.edveleerveEedyealrealarlLgekddYlevfdpdmkysdtpiaasisedLadIyqdl 118
                 +  ++++++ +e +  + lr+++++ L+e+   l++f++dmk + +  ++ i +dL ++ +++
  EFC36230.1  54 DeLKQDIKQEFE-KFKSDLRSEIKNELKEQ---LDEFKQDMKQEFEMCKNDIKDDLGKVTKNI 112
                 223556666666.88899999999999955...899999998776666699999999998765 PP

>> DUF1837  Domain of unknown function (DUF1837)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   4.0   0.00023     0.044     175     213 ..      17      58 ..      11      71 .. 0.79
   2 ?    3.1   3.9      0.36        69     113     212 ..      71     103 ..      61     128 .. 0.55

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 0.00023
     DUF1837 175 viligydsditkklkeesdeykdeikeeikkkvkaikk...e 213
                 +++++++++i+k+ k+e +++k ++++eik+  k+ ++   +
  EFC36230.1  17 TMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDelkQ 58 
                 79**************99999999999999999987774331 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.36
     DUF1837 113 lksaideaveslkkflnedslnkelnlisnrlddedeelreaikklldpstslddknvrlnfviligydsditkklkeesdeykdeikeeikkkvkaik 211
                 l s i                                                                   +++lke+ de+k+++k+e ++ +++ik
  EFC36230.1  71 LRSEI-------------------------------------------------------------------KNELKEQLDEFKQDMKQEFEMCKNDIK 102
                 44443...................................................................333333444444444444444444443 PP

     DUF1837 212 k 212
                 +
  EFC36230.1 103 D 103
                 3 PP

>> Band_7  SPFH domain / Band 7 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   3.8    0.0029      0.56      82     135 ..      18      86 ..       5      96 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.0029
      Band_7  82 v............eresanldnlirrvlesalrevi..semtleellsn.reelaeelknelneqlrky 135
                 +            ++e ++ ++ +r+ ++++l+e++   + ++++ +++ +++l++e+knel+eql+++
  EFC36230.1  18 MfvvfqenikkdiKQELEKFKSDLRSEIKNELKEQLdeLKQDIKQEFEKfKSDLRSEIKNELKEQLDEF 86 
                 333333334444455566668888888888888888443333344444447999999999999998886 PP

>> GreA_GreB_N  Transcription elongation factor, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   1.0     0.009       1.7       9      35 ..      28      54 ..      22      56 .. 0.89
   2 ?    7.1   0.9     0.031       5.9       9      35 ..      58      84 ..      54     103 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.009
                 HHHHHHHHHHHHXHHHHHHHHHHHHHH CS
  GreA_GreB_N  9 ekleeeLeelktverpeiaeaikeare 35
                 + +++eLe+ k+  r ei +++ke+ +
   EFC36230.1 28 KDIKQELEKFKSDLRSEIKNELKEQLD 54
                 679********************9865 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.031
                 HHHHHHHHHHHHXHHHHHHHHHHHHHH CS
  GreA_GreB_N  9 ekleeeLeelktverpeiaeaikeare 35
                 + +++e e+ k+  r ei +++ke+ +
   EFC36230.1 58 QDIKQEFEKFKSDLRSEIKNELKEQLD 84
                 6799*******************9876 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   5.7   0.00054       0.1     121     192 ..      16      94 ..       2     123 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00054
      AAA_11 121 e......kaqlakeiskeleklakelrafeeeeekeklkkskekskskleqerrklkkerk.elskeleeaeesleeev 192
                 +      + +++k+i++elek +++lr++ ++e ke+l++ k++ k++ e+ +++l++e+k el+++l+e+++ +++e+
  EFC36230.1  16 QtmfvvfQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKnELKEQLDEFKQDMKQEF 94 
                 2345555666777777777777777777777777777777777776666666666666543256666666666666543 PP

>> YojJ  Bacterial membrane-spanning protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   7.8      0.32        61       7      35 ..      23      52 ..       3      70 .. 0.73
   2 ?    5.1   2.9      0.12        24       8      34 ..      54      81 ..      47      84 .. 0.73
   3 ?    6.1   1.0     0.062        12       8      29 ..      84     105 ..      77     125 .. 0.59

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.32
        YojJ  7 eeelkeklkeeLeqiekel.eevlkaldee 35
                +e++k+++k+eLe+ + +l +e+ ++l+e+
  EFC36230.1 23 QENIKKDIKQELEKFKSDLrSEIKNELKEQ 52
                688999999999998888833444555554 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.12
        YojJ  8 eelkeklkeeLeqiekel.eevlkalde 34
                 elk+++k+e+e+ + +l +e+ ++l+e
  EFC36230.1 54 DELKQDIKQEFEKFKSDLrSEIKNELKE 81
                6899999999999999983345555665 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.062
        YojJ   8 eelkeklkeeLeqiekeleevl 29 
                  e+k+++k+e+e  ++++++ l
  EFC36230.1  84 DEFKQDMKQEFEMCKNDIKDDL 105
                 5788888888875444444322 PP

>> THOC7  Tho complex subunit 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  10.8    0.0014      0.27      15      98 ..      29     119 ..       8     127 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.0014
       THOC7  15 plkrltkrllklltsla....esteeeleqlkedllldfaafelsie......rlqllakanerereryeaekeeieseieavreeieelkaqL 98 
                  +k+ ++++ + l        ++ +e+l++lk+d++++f++f++ ++        + l++  +  ++++e  k++i++ + +v ++i  l + L
  EFC36230.1  29 DIKQELEKFKSDL---RseikNELKEQLDELKQDIKQEFEKFKSDLRseikneLKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTKNICTLYELL 119
                 3444444444433...144478899**********************999665456788889999**********************9998877 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   5.3   0.00097      0.18      38     119 ..       5      87 ..       1      92 [. 0.80
   2 ?    6.4   1.6     0.026       4.9      56     110 ..      53     111 ..      50     117 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00097
      ATPase  38 qFlikgaekygepgvfvtveepa.edlrenakslGwdlekleeegklaiidasesaeesaeekdkedle.elieelaeaikeik 119
                  ++ + ++k + +++fv + e+  +d++++ +++  dl+   ++++   +d  +++++++ ek k+dl+ e+++el+e ++e+k
  EFC36230.1   5 DYIANCLKK-EMQTMFVVFQENIkKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRsEIKNELKEQLDEFK 87 
                 577777666.99*******998669**************999998999999999999888887777775256677888777776 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.026
      ATPase  56 veepaedlrenakslGwdlekleeegklaiidasesaeesaee....kdkedleeliee 110
                 ++e ++d++++++++  dl+   ++++   +d ++++ +++ e    + k+dl +++++
  EFC36230.1  53 LDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEmcknDIKDDLGKVTKN 111
                 68999***************999999999999999998877763433334444444333 PP

>> HlyD_2  HlyD family secretion protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4  13.8     0.001      0.19      90     176 ..      17     104 ..       5     124 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.001
      HlyD_2  90 kvaeiqkseadeklkekletlnerikeienneaieniekdiekldreInvlekdikesiknedikkieelKeelnalldk.Kkllygs 176
                  ++ + ++++++++k++le+ + ++ +  +ne  e++++ ++++ +e ++ + d++ +ikne  ++++e K+++++  ++ K+ + ++
  EFC36230.1  17 TMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMcKNDIKDD 104
                 4566778888888899999988888776666667777888888888888888888888888888888888888888887645555555 PP

>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   7.9     0.001      0.19     504     579 ..      23     101 ..       6     119 .. 0.55

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.001
                 HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGSTHHHHHHHHHHHHHHHCHTTSSC...HHHH CS
       HSP70 504 eeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleeeaekvseaekekvesaieeLkeeleeee...keei 579
                 +e+i+k +k++ e  ++d + + + e k++++el +++++++e+ ++ ++++ k++++++++e k+ +++e    k++i
  EFC36230.1  23 QENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFemcKNDI 101
                 4555555555555555666666666666666666666666666666666666666666666666666533332222222 PP

>> DUF1269  Protein of unknown function (DUF1269)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.3    0.0024      0.46      46      97 ..       5      55 ..       2      58 .. 0.88
   2 ?    1.0   0.2       2.7   5.2e+02      69      96 ..      58      84 ..      50      88 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0024
     DUF1269 46 kelgeklkpgtsalfllvekatvdkvlealaklggkvlrtslskeeeekLqe 97
                + +++ lk++  ++f+++++   +++ ++l+k++++ lr+++++e +e+L+e
  EFC36230.1  5 DYIANCLKKEMQTMFVVFQENIKKDIKQELEKFKSD-LRSEIKNELKEQLDE 55
                568889999*************************76.689999999999876 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 2.7
     DUF1269 69 dkvlealaklggkvlrtslskeeeekLq 96
                +++ ++++k++++ lr+++++e +e+L+
  EFC36230.1 58 QDIKQEFEKFKSD-LRSEIKNELKEQLD 84
                3455566666643.45666666666554 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.3      0.24        47      76     104 ..       7      33 ..       3      41 .. 0.83
   2 ?    7.7  10.2     0.022       4.2      14     101 ..      21     105 ..      11     109 .. 0.59

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.24
                 HHHHHCSSSTTTTTTHHHHHHHHHHHHHH CS
         RGS  76 lekrlekeqpsrklfeeaqeevfellekd 104
                 ++++l+k  +++++f   qe++ + ++++
  EFC36230.1   7 IANCLKK--EMQTMFVVFQENIKKDIKQE 33 
                 7888999..9************9998865 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.022
                 HHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHHH CS
         RGS  14 lFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqeevfell 101
                 +F+e +++  ++e  +F  +     k++ +e+l +  ++I +e+ + +s+   +i+++l+e+l ++    q +++ fe++++ + + l
  EFC36230.1  21 VFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFK---QDMKQEFEMCKNDIKDDL 105
                 4555555555555555555543333333555555555555555555555555555555555555553...67**********999876 PP

>> RRF  Ribosome recycling factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1  12.9     0.006       1.1      92     160 ..      24     100 ..       2     126 .. 0.59

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.006
                 HHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHC.......S-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         RRF  92 kelvkeakkaaekakvairn.iRrdankklkklekk.......iseDdvkkaekeiqkltdkyikeidellkakeke 160
                 +++ k++k++ ek+k  +r+ i+++ +++l +l+++       +++D   ++++e+++  d++ +++++ ++  +++
  EFC36230.1  24 ENIKKDIKQELEKFKSDLRSeIKNELKEQLDELKQDikqefekFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKND 100
                 45566666666666664442234444444433332222234445556666666666666666666666555544443 PP

>> SICA_alpha  SICA extracellular alpha domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   1.7     0.019       3.6      25      67 ..       7      49 ..       2      52 .. 0.72
   2 ?    4.1  13.5       0.2        38      21      76 ..      48     113 ..      21     123 .. 0.61

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.019
  SICA_alpha 25 itekLkkelekmfeeLkkrLkkqeskeiaklCadvkeevekkk 67
                i++ Lkke+++mf  +++++kk+ ++e +k+ +d+ +e++++ 
  EFC36230.1  7 IANCLKKEMQTMFVVFQENIKKDIKQELEKFKSDLRSEIKNEL 49
                5667888888888888888888888888887777777766554 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.2
  SICA_alpha  21 kakeitekLkkelekmfeeLkkrLkkqeskeiaklCadvkeevekkkkee..........ymkelC 76 
                 + ke  ++Lk++++++fe++k+ L ++ ++e ++  +++k++++++ +              k++C
  EFC36230.1  48 ELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCkndikddlgkVTKNIC 113
                 445556777777777777777777777777777766666666654333225555666666666666 PP

>> DUF4337  Domain of unknown function (DUF4337)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   6.4    0.0014      0.27      35     108 ..      14      91 ..       3     105 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.0014
     DUF4337  35 easdqWafYQAksikehlaeleleqlelllkak.aeelaaavdkkiakykkkiarykke.....kkeikkkAkeleaerd 108
                 e   ++  +Q  +ik+++ +  le+++ +l+++ ++el+++ d+ ++++k++ ++ k++     k+e+k++ +e++++ +
  EFC36230.1  14 EMQTMFVVFQ-ENIKKDIKQE-LEKFKSDLRSEiKNELKEQLDELKQDIKQEFEKFKSDlrseiKNELKEQLDEFKQDMK 91 
                 5556666677.4677776665.788888888888*************************955555555555555444443 PP

>> IMD  IRSp53/MIM homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6  14.2    0.0014      0.27      66     157 ..      26     119 ..      13     131 .] 0.83

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.0014
                 HHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..HHTTHCCCS-CHHHHHHHHHHHHHHHHHHH CS
         IMD  66 rhRsieskLeelvkalhdsLlnpleekveedkkvlnqldkdyakEykkkraelkKkssellk..lqkKakkgkddlkvqldelledvndkylll 157
                  +++i+++Le++ + l  ++ n+l+e+++e k+ ++q   +++ + +++ ++  K + +  k  +++  +  k+d+k +l ++ +++  +y ll
  EFC36230.1  26 IKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKqdMKQEFEMCKNDIKDDLGKVTKNICTLYELL 119
                 5789*******************************************998776666666666235555566****************9999765 PP

>> PSD4  Protein of unknown function (DUF1592)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.3      0.17        32      75     110 ..      16      52 ..       3      58 .. 0.74
   2 ?    8.6   0.5     0.013       2.5      67     127 ..      55     117 ..      48     118 .. 0.66

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.17
        PSD4  75 kelfpefdealreamreetelfveevleedk.svkel 110
                 ++ f  f+e++++++++e+e+f +++ +e k ++ke 
  EFC36230.1  16 QTMFVVFQENIKKDIKQELEKFKSDLRSEIKnELKEQ 52 
                 4677789999999999999999888766644355555 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.013
        PSD4  67 rl.etvekdkelfp.efdealreamreetelfveevleedksvkelltadytfvnerlaahYg 127
                 +l ++++++ e+f+ +++++++++++e++++f +++ +e +  k+ ++ d   v+++++ +Y+
  EFC36230.1  55 ELkQDIKQEFEKFKsDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTKNICTLYE 117
                 443444445555555666667777777777777777777777888888888888888888886 PP

>> P35  Apoptosis preventing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   1.6    0.0019      0.36      28      87 ..       4      65 ..       1      70 [. 0.77
   2 ?    5.3   1.8     0.054        10      60      94 ..      68     102 ..      61     122 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.0019
         P35 28 lvyinkimntql.tkpvlmmfnisgpirsvtrk.nnnlrdrikskideqfdqlerdysdqmd 87
                l yi + ++ ++ t  v++  ni   i+    k + +lr  ik+++ eq+d+l++d  ++++
  EFC36230.1  4 LDYIANCLKKEMqTMFVVFQENIKKDIKQELEKfKSDLRSEIKNELKEQLDELKQDIKQEFE 65
                6677666665542667778889**9999766552789******************9887665 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.054
         P35  60 nnnlrdrikskideqfdqlerdysdqmdglhdnik 94 
                 + +lr  ik+++ eq+d++++d  ++++  +++ik
  EFC36230.1  68 KSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIK 102
                 5689*******************999999888887 PP

>> PilJ  Type IV pili methyl-accepting chemotaxis transducer N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.7    0.0055       1.1      40      93 ..      23      76 ..      11     119 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0055
        PilJ 40 aaearaqlretiaqfdrtlaalrlgdpapgllvpaeavraqleaveqlWqelkk 93
                ++  ++++++ ++ f   l++  + +++ +l   ++++++++e+  ++ +   k
  EFC36230.1 23 QENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIK 76
                566678889999999999999999999988888888888888887776655544 PP

>> SpoIIID  Stage III sporulation protein D
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.4     0.008       1.5      25      61 ..      15      51 ..       5      61 .. 0.85
   2 ?    1.6   0.1       1.5   2.9e+02      45      60 ..      65      80 ..      54     111 .. 0.55
   3 ?   -0.6   0.0       7.4   1.4e+03      27      47 ..      92     112 ..      85     126 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.008
     SpoIIID 25 aakvfgvskstvhkDvterLkkinkklakqvkevLek 61
                + ++f v +  + kD+ + L+k  + l +++k+ L+ 
  EFC36230.1 15 MQTMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKE 51
                5578999999*******************99997765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 1.5
     SpoIIID 45 kkinkklakqvkevLe 60
                +k  + l +++k+ L+
  EFC36230.1 65 EKFKSDLRSEIKNELK 80
                3333333333333322 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 7.4
     SpoIIID  27 kvfgvskstvhkDvterLkki 47 
                 ++f + k  +  D+ +  k+i
  EFC36230.1  92 QEFEMCKNDIKDDLGKVTKNI 112
                 567777777777776655554 PP

>> Nop25  Nucleolar protein 12 (25kDa)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   6.0     0.016         3      38      78 ..      23      63 ..      21      70 .. 0.90
   2 ?    7.9   3.9     0.021         4      46      78 ..      61      97 ..      58     117 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.016
       Nop25 38 qeeakeqereerieeRkklreerkkeleeqleevketlkes 78
                qe++k+  ++e  + +  lr e k+el+eql+e+k+ +k++
  EFC36230.1 23 QENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQE 63
                899*********************************99984 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.021
       Nop25 46 reerieeRkklreerkkeleeqleevketlke....s 78
                ++e  + +  lr e k+el+eql+e+k+ +k+     
  EFC36230.1 61 KQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQefemC 97
                555667788999*****************99943321 PP

>> Annexin  Annexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   1.4     0.019       3.5      28      53 ..      11      36 ..       5      57 .. 0.86
   2 ?    5.7   0.7     0.078        15      33      56 ..      58      80 ..      52      86 .. 0.85
   3 ?    0.2   0.1       4.2   8.1e+02      36      53 ..      91     107 ..      83     113 .. 0.61

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.019
                THHHHHHHHHHHHHHHSS-HHHHHHH CS
     Annexin 28 snaqlqaifeeYkkkygkdLekdIks 53
                 ++++q  f  ++++ +kd+ + +++
  EFC36230.1 11 LKKEMQTMFVVFQENIKKDIKQELEK 36
                5789****************999876 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.078
                HHHHHHHHHHHSS-HHHHHHHHS- CS
     Annexin 33 qaifeeYkkkygkdLekdIksets 56
                q+i++e++ k++ dL + Ik+e++
  EFC36230.1 58 QDIKQEFE-KFKSDLRSEIKNELK 80
                68999996.599999999999987 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 4.2
                 HHHHHHHHSS-HHHHHHH CS
     Annexin  36 feeYkkkygkdLekdIks 53 
                 ++e+ ++ ++d+ +d+ +
  EFC36230.1  91 KQEF-EMCKNDIKDDLGK 107
                 4444.3566777777655 PP

>> HYLS1_C  Hydrolethalus syndrome protein 1 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.5     0.057        11      25      58 ..      22      56 ..       7      64 .. 0.71
   2 ?    6.1   0.3       0.1        20      33      59 ..      61      87 ..      54     100 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.057
     HYLS1_C 25 ykeewe.kfkvpgekkrkelrweireqllqkeeep 58
                ++e+ +  +k   ek +++lr ei+++l+++ +e 
  EFC36230.1 22 FQENIKkDIKQELEKFKSDLRSEIKNELKEQLDEL 56
                5554431456777999999********99996654 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.1
     HYLS1_C 33 kvpgekkrkelrweireqllqkeeeps 59
                k   ek +++lr ei+++l+++ +e +
  EFC36230.1 61 KQEFEKFKSDLRSEIKNELKEQLDEFK 87
                555688899999999999999965544 PP

>> FliT  Flagellar protein FliT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   2.0     0.021         4      52      74 ..      40      62 ..      11      66 .. 0.85
   2 ?    6.3   0.3     0.089        17      53      74 ..      71      92 ..      69      95 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.021
                HHHHHHHHHHHHHHHHHHHHHCH CS
        FliT 52 andaeirallqprldelqkllga 74
                ++  ei++ l+++ldel++++++
  EFC36230.1 40 DLRSEIKNELKEQLDELKQDIKQ 62
                6778****************998 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.089
                HHHHHHHHHHHHHHHHHHHHCH CS
        FliT 53 ndaeirallqprldelqkllga 74
                +  ei++ l+++lde ++++++
  EFC36230.1 71 LRSEIKNELKEQLDEFKQDMKQ 92
                6789***************998 PP

>> SASP  Small, acid-soluble spore proteins, alpha/beta type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   2.4      0.26        49       6      22 ..      47      63 ..      23      76 .. 0.64
   2 ?    7.2   0.2     0.027       5.2       6      27 ..      77      98 ..      72     114 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.26
                GGGHHHHHHHHHHHHHH CS
        SASP  6 peakeaLdqlKyEvAaE 22
                 e ke+Ld+lK ++ +E
  EFC36230.1 47 NELKEQLDELKQDIKQE 63
                34555555665555555 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.027
                GGGHHHHHHHHHHHHHHHT--- CS
        SASP  6 peakeaLdqlKyEvAaElGvsl 27
                 e ke+Ld++K ++ +E+ +  
  EFC36230.1 77 NELKEQLDEFKQDMKQEFEMCK 98
                6889*************99553 PP

>> ZnuA  Zinc-uptake complex component A periplasmic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   1.4    0.0099       1.9     107     152 ..      28      70 ..      18      76 .. 0.72
   2 ?    4.3   0.2      0.12        23     129     152 ..      77     100 ..      73     106 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0099
                 HHHHHHHHHHTGGGHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSGT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ZnuA 107 eniadaLveadpanadtyeanaaayiekLeeldaeireelaeipee 152
                 + i+++L + + +  ++++   ++++e+L+el+++i++e+++ +++
  EFC36230.1  28 KDIKQELEKFKSDLRSEIK---NELKEQLDELKQDIKQEFEKFKSD 70 
                 4455555555555555554...57899*************988865 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.12
                 HHHHHHHHHHHHHHHHHHTTSSGT CS
                 xxxxxxxxxxxxxxxxxxxxxxxx RF
        ZnuA 129 aayiekLeeldaeireelaeipee 152
                 ++++e+L+e+++++++e++ ++++
  EFC36230.1  77 NELKEQLDEFKQDMKQEFEMCKND 100
                 6899**************988865 PP

>> V-SNARE  Vesicle transport v-SNARE protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2  11.8    0.0081       1.5       5      72 ..      23      92 ..      19     107 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0081
     V-SNARE  5 laeiksklarlsslag.eerkaalreiekkldeaeelldq.MelEvrnlpsserasykaklreykselkk 72
                +++ik+ +++  ++   + r++  +e++++lde+++ ++q +e   ++l s  ++++k++l e+k+++k+
  EFC36230.1 23 QENIKKDIKQELEKFKsDLRSEIKNELKEQLDELKQDIKQeFEKFKSDLRSEIKNELKEQLDEFKQDMKQ 92
                667777777766555547999999**************98577777788889999999999999999986 PP

>> CCDC74_C  Coiled coil protein 74, C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.6     0.046       8.8      21      44 ..      24      47 ..      16      53 .. 0.82
   2 ?    6.2   2.9     0.076        14      19      50 ..      52      84 ..      47     128 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.046
    CCDC74_C 21 qnanslQaqElqrlKslLeevlns 44
                 n+++   qEl++ Ks+L+  +++
  EFC36230.1 24 ENIKKDIKQELEKFKSDLRSEIKN 47
                67778889***********98775 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.076
    CCDC74_C 19 qlqnanslQaqElqrlKslLeevlnsk.katse 50
                ql + ++   qE ++ Ks+L+  ++++ k + +
  EFC36230.1 52 QLDELKQDIKQEFEKFKSDLRSEIKNElKEQLD 84
                78888888899*********9877643133333 PP

>> Focal_AT  Focal adhesion targeting region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   2.1      0.18        33      51     104 ..      11      65 ..       6      68 .. 0.76
   2 ?    8.4   0.3     0.011         2      52      88 ..      76     112 ..      68     127 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.18
    Focal_AT  51 Lltsvdellsslpasarreielaekvlskdla.elisamklaqqyssttldeeyr 104
                 L +++++++  ++++ +++i+ + +  ++dl+ e+ +++k+   + +   ++e+ 
  EFC36230.1  11 LKKEMQTMFVVFQENIKKDIKQELEKFKSDLRsEIKNELKEQLDELKQDIKQEFE 65 
                 6678889999999999999999999999999724556777777777766777665 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.011
    Focal_AT  52 ltsvdellsslpasarreielaekvlskdlaelisam 88 
                  ++ +e l+++++++++e e+ ++ ++ dl ++ +++
  EFC36230.1  76 KNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTKNI 112
                 57889999***********************998877 PP

>> T3SS_needle_F  Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1       1.6   3.1e+02       3      25 ..      25      47 ..       4      51 .. 0.78
   2 ?    6.0   0.2     0.069        13       2      30 ..      43      71 ..      42      74 .. 0.88
   3 ?    6.1   0.2     0.069        13       2      32 ..      73     103 ..      72     110 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 1.6
                   HHHHHHHCCTHHHHHHHHHHHHH CS
  T3SS_needle_F  3 svasalsqkvskaekelqdalea 25
                   ++++  +q+++k +++l++ +++
     EFC36230.1 25 NIKKDIKQELEKFKSDLRSEIKN 47
                   56677777777777777777765 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.069
                   HHHHHHHHCCTHHHHHHHHHHHHHHHHST CS
  T3SS_needle_F  2 dsvasalsqkvskaekelqdalealkadp 30
                   ++++++l+++++++++++++  e+ k d+
     EFC36230.1 43 SEIKNELKEQLDELKQDIKQEFEKFKSDL 71
                   5799****************999987776 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.069
                    HHHHHHHHCCTHHHHHHHHHHHHHHHHSTTX CS
  T3SS_needle_F   2 dsvasalsqkvskaekelqdalealkadpsd 32 
                    ++++++l++++++ ++++++  e  k+d++d
     EFC36230.1  73 SEIKNELKEQLDEFKQDMKQEFEMCKNDIKD 103
                    5799*****************9999988865 PP

>> 7TMR-HDED  7TM-HD extracellular
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   8.1    0.0044      0.84      41     117 ..      22      96 ..      13     129 .. 0.55

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0044
   7TMR-HDED  41 ldpevteqvrqelenlleeleelratseenlselieqlkqarekyaqa.........gaelsdeelrallelsdeeleelqqgieq 117
                 ++++++++++qele++ ++   lr++ +++l+e++++lkq ++++ ++         +        ++l e  de+ ++++q+ e 
  EFC36230.1  22 FQENIKKDIKQELEKFKSD---LRSEIKNELKEQLDELKQDIKQEFEKfksdlrseiK--------NELKEQLDEFKQDMKQEFEM 96 
                 678999999*******999...777666777777777777776665545333433331........23333333333333332222 PP

>> DUF3502  Domain of unknown function (DUF3502)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   1.0     0.075        14      96     127 ..      27      55 ..       2      58 .. 0.71
   2 ?    8.1   0.8     0.021       3.9      97     129 ..      59      87 ..      56      88 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.075
     DUF3502  96 v.DpeetlpkfneklkaaGidkviaelqkQlda 127
                   D++++l+kf+++l++     +++el++Qld+
  EFC36230.1  27 KkDIKQELEKFKSDLRSE----IKNELKEQLDE 55 
                 337888888888888876....**********8 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.021
     DUF3502  97 DpeetlpkfneklkaaGidkviaelqkQldafl 129
                 D++++++kf+++l++     +++el++Qld+f+
  EFC36230.1  59 DIKQEFEKFKSDLRSE----IKNELKEQLDEFK 87 
                 9999999999999987....************8 PP

>> DUF3763  Protein of unknown function (DUF3763)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0       5.7   1.1e+03       3      16 ..      29      42 ..      26      44 .. 0.75
   2 ?    9.5   0.9    0.0052      0.99       2      26 ..      47      71 ..      46      73 .. 0.91
   3 ?    3.3   0.4      0.45        85       2      17 ..      77      92 ..      76      95 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 5.7
                HHHHHHHHHHHHHH CS
     DUF3763  3 ewleqleeleqelr 16
                 ++++le+ +++lr
  EFC36230.1 29 DIKQELEKFKSDLR 42
                57788888888887 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.0052
                HHHHHHHHHHHHHHHHHHHHHHTT- CS
     DUF3763  2 eewleqleeleqelrkqrslFhqhq 26
                +e++eql+el+q+++++ ++F + +
  EFC36230.1 47 NELKEQLDELKQDIKQEFEKFKSDL 71
                799******************9876 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.45
                HHHHHHHHHHHHHHHH CS
     DUF3763  2 eewleqleeleqelrk 17
                +e++eql+e +q++++
  EFC36230.1 77 NELKEQLDEFKQDMKQ 92
                7899999999999987 PP

>> RB_A  Retinoblastoma-associated protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   1.7      0.08        15      32      72 ..      19      58 ..       4      67 .. 0.42
   2 ?   10.5   4.5     0.002      0.39      13      96 ..      45     126 ..      39     129 .. 0.54

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.08
        RB_A 32 fksctedpteeiekrvkelsekflkkyaesseeeessslae 72
                f   +e+ +++i+++++++++ + ++ +++ +e+  + l++
  EFC36230.1 19 FVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQ-LDELKQ 58
                3333444444444444444444433333333333.122222 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.002
        RB_A  13 LrellsslsdepsekLlelfksctedpteeiekrvkelsekflkkyaesseeeessslaeelakkrlklaekLYykvLesilks 96 
                 +++ l+++ de ++++++ f++ + d  +ei++++ke  ++f+++++++ e   ++ ++++l  k +k +++LY  +L + lk+
  EFC36230.1  45 IKNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMC-KNDIKDDL-GKVTKNICTLYELLLTQHLKD 126
                 44444555555555555555555555555555555555555555433333333.22225555.556677889998888877765 PP

>> Cas_DxTHG  CRISPR-associated (Cas) DxTHG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   9.0    0.0048      0.91     203     301 ..      20      97 ..       2     127 .. 0.51

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0048
   Cas_DxTHG 203 lkklkklkeklkkeleefskalelirplellekaeklekeiveklkeeleei.esleeeesakplellldeikkklekflkkqikwclekgliqqaltl 300
                   + +++k+ +k+ele+f+  l+   + el e+ ++l    ++++k+e e++ +           +++ +e+k++l++f          k+  +q++++
  EFC36230.1  20 VVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDEL----KQDIKQEFEKFkS--------DLRSEIKNELKEQLDEF----------KQDMKQEFEM 96 
                 3334477777777888888888888744443322222....3335555555522........23344666666666666..........1222222222 PP

   Cas_DxTHG 301 l 301
                 +
  EFC36230.1  97 C 97 
                 2 PP

>> CsgF  Type VIII secretion system (T8SS), CsgF protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.8     0.069        13      46      83 ..      16      53 ..       7      58 .. 0.81
   2 ?    9.4   2.8    0.0061       1.2      46     112 ..      46     110 ..      43     115 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.069
                ---SS---TSSSTT--SSHHHHHHHHHHHHHHHTTTTT CS
        CsgF 46 qnkfkdkaeasetkekssleeFadsLnrqllsrlsskl 83
                q  f   +e+ +++ k++le+F+ +L + + ++l ++l
  EFC36230.1 16 QTMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQL 53
                5555555567789999*****************99987 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0061
                 ---SS---TSSSTT--SSHHHHHHHHHHHHHHHTTTTT.......S---S--EE-SSEEEEEEEETT CS
        CsgF  46 qnkfkdkaeasetkekssleeFadsLnrqllsrlssklvqqqFgenalkegtytfgsyqieitnsgs 112
                 +n+ k++ ++ +++ k++ e+F+ +L + + ++l ++l  + F ++  +e ++  ++++ ++ ++++
  EFC36230.1  46 KNELKEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQL--DEFKQDMKQEFEMCKNDIKDDLGKVTK 110
                 6889999999999*************************..999999999988887777766666555 PP

>> FapA  Flagellar Assembly Protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9  10.9    0.0055         1     333     421 ..      43     110 ..       6     126 .. 0.39

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0055
        FapA 333 pelkekl.keleeeleeleeeleklkkkikklpklkaekqlesekkeqlkklletkeklkeeleeleeelkelkeeleskkeeakikvnk 421
                  e+k++l ++l+e+ +++++e ek k+++++  k + ++ql++ k+++ ++ + +k+ +k++l                       kv+k
  EFC36230.1  43 SEIKNELkEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDL----------------------GKVTK 110
                 111111112222222222333333333333333322233333333333333333333333333......................33333 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   9.4    0.0068       1.3       8      86 ..      16     102 ..       9     122 .. 0.58

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0068
       TMPIT   8 ekefkeleeta.keykqkleelsk.lqskcskeikkqkkrlk.elksslkklkksvk....eeeeeeveelkeelkerkkvlk.eve 86 
                 ++ f  ++e+  k +kq+le+ ++ l s++++e+k+q  +lk ++k++++k+k++++    +e +e+++e k+++k++ ++ k +++
  EFC36230.1  16 QTMFVVFQENIkKDIKQELEKFKSdLRSEIKNELKEQLDELKqDIKQEFEKFKSDLRseikNELKEQLDEFKQDMKQEFEMCKnDIK 102
                 444555555442567777777643256777777777776665247777777777644333345555555555555555554444444 PP

>> PHA_gran_rgn  Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.2      0.14        27      63      85 ..      14      36 ..      10      37 .. 0.86
   2 ?    3.8   0.2      0.38        72      70      87 .]      36      53 ..      33      56 .. 0.58
   3 ?    3.3   0.1      0.54     1e+02      71      87 .]      67      83 ..      59      86 .. 0.63

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.14
  PHA_gran_rgn 63 kLglllkafkgkieseiekkLdk 85
                  ++  ++ +f++ i++ i+++L+k
    EFC36230.1 14 EMQTMFVVFQENIKKDIKQELEK 36
                  7788999*************986 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.38
  PHA_gran_rgn 70 afkgkieseiekkLdklL 87
                  +fk+ + sei+++L+++L
    EFC36230.1 36 KFKSDLRSEIKNELKEQL 53
                  566666666666666554 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.54
  PHA_gran_rgn 71 fkgkieseiekkLdklL 87
                  fk+ + sei+++L+++L
    EFC36230.1 67 FKSDLRSEIKNELKEQL 83
                  56666666666665544 PP

>> DUF1722  Protein of unknown function (DUF1722)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   7.7       0.3        58      17      85 ..      20      90 ..      12     102 .. 0.75

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.3
     DUF1722 17 rlvanakkepleelaeeYeellmealskpatr..kkhinvlqhilgyfkkklsaeekqelleliekYregk 85
                 + +++ k+++++ +e++++ l++ ++++ +    +  + ++  ++ fk++l +e k+el e+++++++++
  EFC36230.1 20 VVFQENIKKDIKQELEKFKSDLRSEIKNELKEqlDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDM 90
                55566666777788888888888777766544114667778888999********************9975 PP

>> PNPase  Polyribonucleotide nucleotidyltransferase, RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   4.6     0.051       9.6      21      65 ..      25      69 ..       4      77 .. 0.55
   2 ?    7.4   2.5     0.032       6.1       2      55 ..      56     107 ..      55     124 .. 0.71

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.051
                SSHHHHHHHHHHHHHHHHHHHH...HHSTTS-HHHHHHHHHHHHH CS
      PNPase 21 teKqeRyaaldeikekvveafaaeleeedeedekeikeifkalek 65
                  K++ +++l++ k++   ++ +el+e+ +e +++ik+ f++ ++
  EFC36230.1 25 NIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKS 69
                455555555555555555555555555555555555555555544 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.032
                 HHHHHHTTTHHHHHHHTTSSSHHHHHHHHHHHHHHHHHHHH...HHSTTS-HHH CS
      PNPase   2 leekvaelaeerisealtiteKqeRyaaldeikekvveafaaeleeedeedeke 55 
                 l++++++++e + ++ l+ + K+e +++lde k++++++f+   +++ ++d  +
  EFC36230.1  56 LKQDIKQEFE-KFKSDLRSEIKNELKEQLDEFKQDMKQEFEMC-KNDIKDDLGK 107
                 6677777765.57888899999999999999999999999933.3333444333 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   9.8     0.037       7.1      42     109 ..       4      65 ..       1     119 [. 0.68

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.037
                 HHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--.......-SEEEE CS
      ResIII  42 aklierllkkgkeekflflvprkslleqtleefkkflseaykeigkkvsgdkkkakekdstnkkilvt 109
                 +  i+++lkk+   +++f+v ++++ +  ++e++kf+s+ ++ei+++++++ ++     ++++k  ++
  EFC36230.1   4 LDYIANCLKKEM--QTMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDEL----KQDIKQEFE 65 
                 567888888744..9************************9999777766666655....222222222 PP

>> OmpH  Outer membrane protein (OmpH-like)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  17.2     0.013       2.5      17      86 ..      27     100 ..      15     122 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.013
                 HHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHTTTS.......-HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        OmpH  17 gkaaqeqlekkfkklqaeleak.ekelqklqeelqkkakkle......keekeqelqkkeqelqqkqqqkaqelqkk 86 
                  k+++++lek +++l+ e++++ +++l++l+++++++    e      + e ++el+++ +e++q+++q+++  ++ 
  EFC36230.1  27 KKDIKQELEKFKSDLRSEIKNElKEQLDELKQDIKQEF---EkfksdlRSEIKNELKEQLDEFKQDMKQEFEMCKND 100
                 57888888888855555555221223333333333222...223223366666667777777777777766333332 PP

>> EAP30  EAP30/Vps36 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.3      0.48        91      37      55 ..      29      47 ..      11      52 .. 0.74
   2 ?    3.6   7.9      0.18        35      10      52 ..      58     100 ..      25     122 .. 0.56

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.48
       EAP30 37 kfkesLvklaekhkakiks 55
                  k++L+k+ ++++++ik+
  EFC36230.1 29 DIKQELEKFKSDLRSEIKN 47
                4566688888888888876 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.18
       EAP30  10 eqtaaeyqdlgaellaealqdleallakfkesLvklaekhkak 52 
                 ++ ++e+++  + l +e  ++l+++l++fk+ +++  e  k++
  EFC36230.1  58 QDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKND 100
                 2223333334444444444455555555555555555555555 PP

>> TA0956  Thermoplasma acidophilum protein TA0956
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.8    0.0063       1.2      70     102 ..       7      39 ..       4      45 .. 0.93
   2 ?    2.3   1.0         1     2e+02      83     101 ..      69      87 ..      39      95 .. 0.59

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0063
                 EEETTTTEEEEEE-S--CCHHHHHHHHHHHHHC CS
      TA0956  70 iinsdkkvlslsfselkeelkksikeiaekfkk 102
                 i n  kk +   f   +e++kk+ik+++ekfk+
  EFC36230.1   7 IANCLKKEMQTMFVVFQENIKKDIKQELEKFKS 39 
                 67999**************************96 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 1
                 -S--CCHHHHHHHHHHHHH CS
      TA0956  83 selkeelkksikeiaekfk 101
                 s+l+ e+k+++ke++++fk
  EFC36230.1  69 SDLRSEIKNELKEQLDEFK 87 
                 2334444444444444444 PP

>> Bac_RepA_C  Replication initiator protein A C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   2.8     0.014       2.6      37      90 ..      12      65 ..       4      69 .. 0.78
   2 ?    3.4   2.2       0.5        95      34      84 ..      54      89 ..      45     113 .. 0.60

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.014
  Bac_RepA_C 37 ervlgvailldeeelqelitktLrrffnslrisknkkvknvenYlmrtlknlFe 90
                ++ +++++++++e+++++i ++L +f+  lr + +++ k+  + l + +k++Fe
  EFC36230.1 12 KKEMQTMFVVFQENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFE 65
                45566899999999999***9999999999977677777776667777777776 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.5
  Bac_RepA_C 34 ekaervlgvailldeeelqelitktLrrffnslrisknkkvknvenYlmrt 84
                ++ ++++ + +  ++ +l ++i ++L+ ++   +                 
  EFC36230.1 54 DELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQ---------------D 89
                44455555555555555555555555555554442...............2 PP

>> PdaC  Deacetylase PdaC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9  14.3         5   9.5e+02      32      48 ..      52      75 ..       9     120 .. 0.48

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 5
                H.......HHHHHHHHHHHHHHHH CS
        PdaC 32 k.......iekdadkflkeyekea 48
                +       i+++++kf +++++e 
  EFC36230.1 52 QldelkqdIKQEFEKFKSDLRSEI 75
                111111112222222222222222 PP

>> DUF3810  Protein of unknown function (DUF3810)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.8       0.1        19     238     273 ..      23      58 ..       1      67 [. 0.56
   2 ?    6.6   1.7     0.022       4.3     235     285 ..      50     101 ..      47     116 .. 0.72

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.1
     DUF3810 238 lnalykadeeayeellktispevledlkeereywek 273
                  ++++k  +++ e++++++++e++++lke+ +  ++
  EFC36230.1  23 QENIKKDIKQELEKFKSDLRSEIKNELKEQLDELKQ 58 
                 334444434446666666666666666665554444 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.022
     DUF3810 235 syvlnalykadeeayeellktispevledlkeereywek.yegtveevsdkv 285
                 ++ l +l++  ++++e++++++++e++++lke+ + +++ +++++e  ++ +
  EFC36230.1  50 KEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQdMKQEFEMCKNDI 101
                 5667778887666699999999999999999988888775455555555544 PP

>> DUF16  Protein of unknown function DUF16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   9.5       1.6   3.1e+02      26      65 ..      23      68 ..       7      81 .. 0.63
   2 ?   11.0   1.0    0.0023      0.45      23      51 ..      81     109 ..      79     125 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 1.6
                HH.B-..BHHHHHHHHHHHH........HHHHHHHHHHHHHHHHHH CS
       DUF16 26 ne.fkdsnkqrLkkieakvd.....klgeqinkleqkvekqgekik 65
                +e  k++ kq+L+k++  ++      l+eq+++l+q +++  ek k
  EFC36230.1 23 QEnIKKDIKQELEKFKSDLRseiknELKEQLDELKQDIKQEFEKFK 68
                4447888889999888888755555566666666666666666554 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.0023
                 HHHHHB-..BHHHHHHHHHHHH...HHHH CS
       DUF16  23 kqlnefkdsnkqrLkkieakvdklgeqin 51 
                  ql+efk++ kq+++  ++ ++    ++ 
  EFC36230.1  81 EQLDEFKQDMKQEFEMCKNDIKDDLGKVT 109
                 79*****************9995444443 PP

>> Spore_II_R  Stage II sporulation protein R (spore_II_R)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   4.5     0.018       3.4      10      77 ..       7      76 ..       2      81 .. 0.82
   2 ?    7.3   4.2     0.033       6.3      21      82 ..      37     100 ..      35     123 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.018
  Spore_II_R 10 lanSdseeDqklKlkvrdavleeleellkeak..skeeaeelikenleeieeiaeevlekegvdykvkve 77
                +an  ++e q++ +  ++++ + ++++l++ k   ++e ++ +ke+l+e+++ +++++ek + d + +++
  EFC36230.1  7 IANCLKKEMQTMFVVFQENIKKDIKQELEKFKsdLRSEIKNELKEQLDELKQDIKQEFEKFKSDLRSEIK 76
                788889999999999999999999999997763357899999************9999998877766654 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.033
  Spore_II_R  21 lKlkvrdavleeleellkeak..skeeaeelikenleeieeiaeevlekegvdykvkvelgkey 82 
                  K ++r ++ +el+e+l+e k   k+e e++ ++  +ei+++ +e+l + + d+k + e+ k++
  EFC36230.1  37 FKSDLRSEIKNELKEQLDELKqdIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKND 100
                 5777777777777777765442245556666666667777777777776666666666655554 PP

>> AbiH  Bacteriophage abortive infection AbiH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9  11.9     0.027       5.1      74     141 ..      24      93 ..       2     127 .. 0.42

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.027
        AbiH  74 eeliddikdalteylkdsedesdkdvyse..kakeeieeelfneldklisalkqyleewvnkielkssle 141
                 e++++dik++l+++++d  +e ++++ ++  + k++i++e+ ++ ++l+s++k++l+e +++++++ ++e
  EFC36230.1  24 ENIKKDIKQELEKFKSDLRSEIKNELKEQldELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQE 93 
                 3333444444444444433332222222111222344444444444444444444444444443333222 PP

>> CelTOS  Cell-traversal protein for ookinetes and sporozoites
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6  10.4     0.052       9.9      13      86 ..      22      96 ..      11     126 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.052
      CelTOS 13 lssklseiiradldskgdelvdliandlekelq..knslvaasfLqsgfdvkkkaKeiiKkvllevlksllpvvek 86
                +++++++ i+++l++   +l + i n+l ++l+  k++ ++  f + + d+++++K+  K+ l e  + + + +e+
  EFC36230.1 22 FQENIKKDIKQELEKFKSDLRSEIKNELKEQLDelKQD-IKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEM 96
                56788888999999999999999999999988533566.7888888777999999999999998876666555554 PP

>> eIF-4B  Plant specific eukaryotic initiation factor 4B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  11.2     0.023       4.4     357     432 ..      28     104 ..      16     113 .. 0.72

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.023
      eIF-4B 357 rkidlelehrrvd.rpeteeekllkeeieelkkelekeaa.enkesqqessed.qnslkelisekekdlellirelddk 432
                 + i +ele  + d r+e ++e  lke+++elk+++++e +  +++ ++e +++ +++l e  +++++++e+  +++ d 
  EFC36230.1  28 KDIKQELEKFKSDlRSEIKNE--LKEQLDELKQDIKQEFEkFKSDLRSEIKNElKEQLDEFKQDMKQEFEMCKNDIKDD 104
                 457899998777758999888..9***********99976323333333333336777777788888999998888775 PP

>> Pet100  Pet100
   [No individual domains that satisfy reporting thresholds (although complete target did)]

>> OTU  OTU-like cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   1.4      0.11        21      19      59 ..      23      70 ..       8      74 .. 0.60
   2 ?    6.4   0.8     0.062        12      25      61 ..      66     102 ..      56     119 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.11
                .S.......HCCHHHHHHHHHCHHHHHHTSSHHCCHHHHCCHHHHHHH CS
         OTU 19 sd.......elrkakvseLreklaeylrehseelelfleeeeegylke 59
                ++       ++ ++ +s Lr++ +++l+e+ +el+  +++e+e++ ++
  EFC36230.1 23 QEnikkdikQELEKFKSDLRSEIKNELKEQLDELKQDIKQEFEKFKSD 70
                335443333222234458999999999999999999888887776555 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.062
                 HHHHHHHHCHHHHHHTSSHHCCHHHHCCHHHHHHHTT CS
         OTU  25 akvseLreklaeylrehseelelfleeeeegylkeie 61 
                 + +s Lr++ +++l+e+ +e++  +++e+e+  ++i+
  EFC36230.1  66 KFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIK 102
                 3457899999999999999999999999777555554 PP

>> Arc_PepC_II  Archaeal Peptidase A24 C-terminus Type II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   8.1       2.1     4e+02      17      59 ..      15      58 ..       8     117 .. 0.72

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 2.1
  Arc_PepC_II 17 llkkflflleefeekdgk.ikrkfisvekeldeelrkelkkykk 59
                 +++ f++  e+++++ ++ +++   + ++e+++el+++l+++k+
   EFC36230.1 15 MQTMFVVFQENIKKDIKQeLEKFKSDLRSEIKNELKEQLDELKQ 58
                 45555555555555544445555555555555555555555544 PP

>> AKNA  AT-hook-containing transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   5.7      0.13        24      38      76 ..      39      71 ..      23      77 .. 0.61
   2 ?    6.3   2.8      0.08        15      41      79 ..      72     104 ..      65     123 .. 0.64

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.13
        AKNA 38 fdpsreleaeIyqlgqrleeLkdqtdqlkqkveefskdi 76
                +d  +e+  e   l++ l+eLk  +   kq+ e+f +d+
  EFC36230.1 39 SDLRSEIKNE---LKEQLDELKQDI---KQEFEKFKSDL 71
                4555555555...566666666443...45555555555 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.08
        AKNA  41 sreleaeIyqlgqrleeLkdqtdqlkqkveefskdiaqd 79 
                  +e+  e   l++ l+e k  +   kq+ e +  di+ d
  EFC36230.1  72 RSEIKNE---LKEQLDEFKQDM---KQEFEMCKNDIKDD 104
                 5555555...555555555443...56666677777665 PP

>> Dynein_light  Dynein light chain type 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1  11.4       6.2   1.2e+03      14      46 ..      23      55 ..       2     115 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 6.2
                  HHHHHHHHHHHHHH-SSHH..HHHHHHHHHHHH CS
  Dynein_light 14 qeeaielakealekfkkekekdiaayikkeldk 46
                  qe + + +k++lekfk++  ++i +++k++ld+
    EFC36230.1 23 QENIKKDIKQELEKFKSDLRSEIKNELKEQLDE 55
                  555555556666655554334444444444443 PP

>> Toxin_trans  Clostridium neurotoxin, Translocation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   1.4     0.023       4.3     187     231 ..       3      47 ..       1      51 [. 0.91
   2 ?    3.8   4.6      0.14        26     174     238 ..      50     114 ..      46     122 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.023
                  HHHHHHHHHHHHHHHCCCCSTTTCCHHHHHHHHHHHHHHHHHHHH CS
  Toxin_trans 187 aleyqaealkkiidykyniyseeekenininindlksklnekink 231
                   l+y a+ lkk ++  + ++ e+ k++i+++++++ks l  +i +
   EFC36230.1   3 NLDYIANCLKKEMQTMFVVFQENIKKDIKQELEKFKSDLRSEIKN 47 
                  699************************************998865 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.14
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSTTTCCHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Toxin_trans 174 ntqfdkikkkmykaleyqaealkkiidykyniyseeekenininindlksklnekinkaminink 238
                    q+d+ k+++++ +e     l+  i+ + +   +e k++++++++  k+ +++++ k   ni +
   EFC36230.1  50 KEQLDELKQDIKQEFEKFKSDLRSEIKNELKEQLDEFKQDMKQEFEMCKNDIKDDLGKVTKNICT 114
                  56899999999999999999999999999999999999999999999999999999999999865 PP

>> VASP_tetra  VASP tetramerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.3     0.001      0.19       2      20 ..      32      50 ..      31      51 .. 0.94
   2 ?    2.4   1.0       0.6   1.1e+02       4      11 ..      53      60 ..      50      63 .. 0.81
   3 ?   10.4   1.0    0.0019      0.36       2      20 ..      62      80 ..      61      81 .. 0.93
   4 ?    1.4   2.7       1.3   2.4e+02       4      14 ..      83      93 ..      80     105 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.001
  VASP_tetra  2 sDlErlKqEILeEvrkELq 20
                ++lE++K ++ +E++ EL+
  EFC36230.1 32 QELEKFKSDLRSEIKNELK 50
                79***************96 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.6
  VASP_tetra  4 lErlKqEI 11
                l+ lKq+I
  EFC36230.1 53 LDELKQDI 60
                89*****9 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.0019
  VASP_tetra  2 sDlErlKqEILeEvrkELq 20
                +++E++K ++ +E++ EL+
  EFC36230.1 62 QEFEKFKSDLRSEIKNELK 80
                79***************96 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 1.3
  VASP_tetra  4 lErlKqEILeE 14
                l+ +Kq++ +E
  EFC36230.1 83 LDEFKQDMKQE 93
                89999996443 PP

>> Uteroglobin  Uteroglobin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   5.5     0.019       3.7      27      80 ..      11      67 ..       5      74 .. 0.82
   2 ?    3.1   2.5      0.61   1.2e+02      37      77 ..      74      94 ..      61     118 .. 0.49

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.019
                 HHHHHHHHH....HS-HHHHHHHHHTT---HHHHHHHHHHHHHHTTS-HHHHHHHHHH CS
  Uteroglobin 27 leevvekfl....egseeeYkeeLqkynpdpeaeealaelKqcvdklsnetkenvakl 80
                 l++++++++    e+ +++ k+eL+k+++d    e + elK+  d+l++  k++++k+
   EFC36230.1 11 LKKEMQTMFvvfqENIKKDIKQELEKFKSDLR-SEIKNELKEQLDELKQDIKQEFEKF 67
                 66666666666657789999*******98765.67899****************9987 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.61
                 S-HHHHHHHHHTT---HHHHHHHHHHHHHHTTS-HHHHHHH CS
  Uteroglobin 37 gseeeYkeeLqkynpdpeaeealaelKqcvdklsnetkenv 77
                 + ++e+ke+L +++                    +  k+++
   EFC36230.1 74 EIKNELKEQLDEFK--------------------QDMKQEF 94
                 33334444444443....................3333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3656  (0.203915); expected 358.6 (0.02)
Passed bias filter:                     1062  (0.0592336); expected 358.6 (0.02)
Passed Vit filter:                       233  (0.0129957); expected 17.9 (0.001)
Passed Fwd filter:                       106  (0.00591221); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              94  [number of targets reported over threshold]
# CPU time: 1.08u 0.38s 00:00:01.46 Elapsed: 00:00:00.57
# Mc/sec: 694.95
//
Query:       EFC36231.1  [L=413]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.2e-11   42.4  13.8    0.00039   20.3   0.6    7.1  7  TPR_2        Tetratricopeptide repeat
    2.6e-10   39.7   5.0     0.0065   16.6   0.3    6.1  5  TPR_8        Tetratricopeptide repeat
    3.3e-09   36.2   9.1     0.0026   17.5   0.9    6.5  8  TPR_1        Tetratricopeptide repeat
      9e-09   34.9   3.5     0.0013   18.3   0.4    4.9  5  TPR_11       TPR repeat
      8e-07   29.3   5.2      0.021   15.1   0.3    4.7  4  TPR_12       Tetratricopeptide repeat
    0.00017   22.1   1.8        5.1    7.7   0.1    5.0  6  TPR_19       Tetratricopeptide repeat
    0.00025   21.6   0.0         72    4.6   0.0    5.8  6  TPR_14       Tetratricopeptide repeat
    0.00042   20.5   1.5       0.93   10.0   0.0    4.9  5  TPR_17       Tetratricopeptide repeat
    0.00073   20.1   0.6       0.39   11.4   0.0    3.6  4  TPR_16       Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.016   15.4   0.1         11    6.2   0.0    3.8  4  TPR_9        Tetratricopeptide repeat
      0.018   14.9   0.5       0.82    9.5   0.0    2.8  2  DUF1524      Protein of unknown function (DUF1524)
      0.021   14.1   6.2      0.035   13.3   6.2    1.5  1  FAT          FAT domain
      0.037   13.9   1.1        6.7    6.7   0.1    4.3  5  TPR_10       Tetratricopeptide repeat
      0.043   13.8   2.7       0.13   12.3   0.1    2.8  3  Mad3_BUB1_I  Mad3/BUB1 homology region 1
      0.046   14.4   1.0       0.61   10.9   0.1    3.1  3  Sel1         Sel1 repeat
        2.4    8.5  11.0         18    5.6   0.0    4.6  5  ANAPC3       Anaphase-promoting complex, cyclosome, subunit 3


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0    0.0014       1.5       2      29 ..      50      77 ..      49      79 .. 0.92
   2 !   11.6   0.0   0.00021      0.24       6      30 ..      99     123 ..      95     124 .. 0.91
   3 !   20.3   0.6   3.5e-07   0.00039       3      31 ..     173     201 ..     171     204 .. 0.94
   4 ?    1.3   0.0      0.42   4.7e+02      12      34 .]     217     239 ..     206     239 .. 0.75
   5 ?   -2.7   0.0       8.2   9.2e+03      27      34 .]     268     275 ..     258     275 .. 0.79
   6 ?   -0.4   0.1       1.4   1.6e+03       8      29 ..     324     345 ..     318     350 .. 0.71
   7 ?    2.0   0.0      0.25   2.8e+02      14      30 ..     366     382 ..     363     385 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0014
       TPR_2  2 ealynlGlayyklgdyeeAleafekAle 29
                +a+  +++  +++ +y eA++ f+kA e
  EFC36231.1 50 RAWISMACFMREAHKYGEAEKTFDKAME 77
                6899999*******************87 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00021
       TPR_2   6 nlGlayyklgdyeeAleafekAlel 30 
                 ++G+ y +lg+ e A ++f+k+ el
  EFC36231.1  99 EMGRNYVHLGKVEHATQCFNKVCEL 123
                 78********************998 PP

  == domain 3  score: 20.3 bits;  conditional E-value: 3.5e-07
       TPR_2   3 alynlGlayyklgdyeeAleafekAleld 31 
                 +++ lG+ y+ ++d + Al+++ekA+eld
  EFC36231.1 173 WNHLLGNYYLLKQDNNSALKHYEKAVELD 201
                 7899************************8 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.42
       TPR_2  12 yklgdyeeAleafekAleldPnn 34 
                  +++d  +A+  + +A  +dP n
  EFC36231.1 217 HQMQDKTKAHLMWSRAFDIDPYN 239
                 35677799999999999999965 PP

  == domain 5  score: -2.7 bits;  conditional E-value: 8.2
       TPR_2  27 AleldPnn 34 
                  l+ldP++
  EFC36231.1 268 GLKLDPED 275
                 59999986 PP

  == domain 6  score: -0.4 bits;  conditional E-value: 1.4
       TPR_2   8 GlayyklgdyeeAleafekAle 29 
                  + + +l++y+ Al  ++  l+
  EFC36231.1 324 SEYLVELKNYNWALGVLNSGLK 345
                 56788999**999987776666 PP

  == domain 7  score: 2.0 bits;  conditional E-value: 0.25
       TPR_2  14 lgdyeeAleafekAlel 30 
                 +++y  Ale++e  l+l
  EFC36231.1 366 MQNYRAALEDCEHILRL 382
                 689*********99987 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.1     0.069        78       2      30 ..      50      78 ..      49      78 .. 0.78
   2 !   10.4   0.0   0.00056      0.63       5      30 ..      98     123 ..      94     124 .. 0.89
   3 !   16.6   0.3   5.8e-06    0.0065       5      33 ..     175     203 ..     174     204 .. 0.93
   4 ?    3.6   0.0     0.084        94       2      20 ..     206     225 ..     205     239 .. 0.80
   5 ?    1.1   0.0      0.52   5.9e+02      12      30 ..     364     382 ..     360     385 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.069
                CHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8  2 eayynlgsiylklgdyeeAkeyyekalel 30
                +a+  +++  ++  +y eA++++ ka e+
  EFC36231.1 50 RAWISMACFMREAHKYGEAEKTFDKAMEM 78
                5666666666677799**********986 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00056
                 HHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekalel 30 
                 + +g+ y  lg+ e A ++++k++el
  EFC36231.1  98 LEMGRNYVHLGKVEHATQCFNKVCEL 123
                 678999*****************998 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 5.8e-06
                 HHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekaleldpd 33 
                 ++lg+ yl ++d ++A + yeka+eld +
  EFC36231.1 175 HLLGNYYLLKQDNNSALKHYEKAVELDTA 203
                 78************************965 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.084
                 CHHHHHHHHH.HHTT-HHHH CS
       TPR_8   2 eayynlgsiy.lklgdyeeA 20 
                 +++  lg+iy ++++d+ +A
  EFC36231.1 206 DSLAVLGDIYfHQMQDKTKA 225
                 67889***********9998 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.52
                 HHTT-HHHHHHHHHHHHHH CS
       TPR_8  12 lklgdyeeAkeyyekalel 30 
                 +++++y +A e +e+ l+l
  EFC36231.1 364 ITMQNYRAALEDCEHILRL 382
                 7899**********99887 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0      0.04        44      12      29 ..      60      77 ..      49      78 .. 0.76
   2 !    7.6   0.0    0.0032       3.6      10      30 ..     103     123 ..      98     125 .. 0.87
   3 !   17.5   0.9   2.3e-06    0.0026       7      31 ..     177     201 ..     175     201 .. 0.96
   4 ?    0.4   0.0      0.57   6.4e+02      11      32 ..     216     237 ..     205     239 .. 0.60
   5 ?   -3.3   0.0       8.5   9.5e+03      28      34 .]     269     275 ..     268     275 .. 0.85
   6 ?   -1.7   0.0       2.8   3.1e+03       2      14 ..     277     289 ..     276     290 .. 0.82
   7 ?   -3.4   0.0       9.2     1e+04      14      21 ..     330     337 ..     329     338 .. 0.75
   8 ?    5.0   0.0     0.021        23      14      30 ..     366     382 ..     364     385 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.04
                HHTT-HHHHHHHHHHHHH CS
       TPR_1 12 fklgkydeAleyyekALe 29
                ++  ky eA++ ++kA e
  EFC36231.1 60 REAHKYGEAEKTFDKAME 77
                66789***********76 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0032
                 HHHHTT-HHHHHHHHHHHHHH CS
       TPR_1  10 ayfklgkydeAleyyekALel 30 
                  y +lgk + A ++++k+ el
  EFC36231.1 103 NYVHLGKVEHATQCFNKVCEL 123
                 5889**************998 PP

  == domain 3  score: 17.5 bits;  conditional E-value: 2.3e-06
                 HHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   7 lGnayfklgkydeAleyyekALeln 31 
                 lGn y+ +++ + Al++yekA+el+
  EFC36231.1 177 LGNYYLLKQDNNSALKHYEKAVELD 201
                 9**********************98 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.57
                 HHHTT-HHHHHHHHHHHHHHST CS
       TPR_1  11 yfklgkydeAleyyekALelnP 32 
                 ++++++  +A    ++A  ++P
  EFC36231.1 216 FHQMQDKTKAHLMWSRAFDIDP 237
                 3455566666666666666666 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 8.5
                 HHHSTTH CS
       TPR_1  28 LelnPnn 34 
                 L+l+P++
  EFC36231.1 269 LKLDPED 275
                 89***86 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 2.8
                 HHHHHHHHHHHHT CS
       TPR_1   2 kalynlGnayfkl 14 
                 +++y +++++ +l
  EFC36231.1 277 NSHYLMAVCLEEL 289
                 5799*****9876 PP

  == domain 7  score: -3.4 bits;  conditional E-value: 9.2
                 TT-HHHHH CS
       TPR_1  14 lgkydeAl 21 
                 l++y+ Al
  EFC36231.1 330 LKNYNWAL 337
                 78888886 PP

  == domain 8  score: 5.0 bits;  conditional E-value: 0.021
                 TT-HHHHHHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyekALel 30 
                 +++y  Ale++e  L+l
  EFC36231.1 366 MQNYRAALEDCEHILRL 382
                 78*********988876 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0     0.014        15       1      23 [.     101     123 ..     101     126 .. 0.93
   2 !   18.3   0.4   1.2e-06    0.0013       1      40 [.     178     217 ..     178     218 .. 0.94
   3 ?   -1.0   0.0       1.3   1.4e+03      17      35 ..     229     248 ..     223     249 .. 0.72
   4 !    7.2   0.0    0.0037       4.1      21      36 ..     269     284 ..     257     289 .. 0.84
   5 ?   -0.6   0.1         1   1.1e+03      14      22 ..     366     374 ..     355     377 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.014
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkl 23 
                 G+ y+ +Gk e A ++++k ++l
  EFC36231.1 101 GRNYVHLGKVEHATQCFNKVCEL 123
                 778999***************98 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 1.2e-06
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40 
                 G+ y  +++++ A+++Y+kA++ld   ++ +  LG++y+ 
  EFC36231.1 178 GNYYLLKQDNNSALKHYEKAVELDTACVDSLAVLGDIYFH 217
                 889999***********************99999999985 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 1.3
      TPR_11  17 YkkAlkldP.dnaeayynLG 35 
                 +++A ++dP +n   +y+L+
  EFC36231.1 229 WSRAFDIDPyNNNLSHYKLA 248
                 57888888845555688887 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0037
      TPR_11  21 lkldPdnaeayynLGl 36 
                 lkldP++++ +y +++
  EFC36231.1 269 LKLDPEDVNSHYLMAV 284
                 8***********9986 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 1
      TPR_11  14 ieaYkkAlk 22 
                 +++Y++Al+
  EFC36231.1 366 MQNYRAALE 374
                 799****98 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0   0.00075      0.84       9      73 ..      55     122 ..      47     124 .. 0.69
   2 ?    1.8   0.0      0.27   3.1e+02       8      72 ..      99     121 ..      91     143 .. 0.66
   3 !   15.1   0.3   1.8e-05     0.021       5      74 ..     172     235 ..     168     237 .. 0.78
   4 ?    2.0   0.3      0.23   2.6e+02      15      36 ..     365     386 ..     356     393 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00075
      TPR_12   9 laavlrrlgrydeAlellekaleiarrllGpdhpltattlrnL....grlyralgryeeAlelleeala 73 
                 +a + r++ +y eA++ ++ka+e++ +   + ++  ++t+  L    gr y  lg+ e A + ++++ +
  EFC36231.1  55 MACFMREAHKYGEAEKTFDKAMEMMIKGS-GFNYKDCITMSSLnlemGRNYVHLGKVEHATQCFNKVCE 122
                 55566778999999999999999996553.466666666655433448888888888888888877766 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.27
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72 
                 +++  + +lg+ + A ++++k+                                           
  EFC36231.1  99 EMGRNYVHLGKVEHATQCFNKV------------------------------------------C 121
                 3555566666666555555554..........................................3 PP

  == domain 3  score: 15.1 bits;  conditional E-value: 1.8e-05
      TPR_12   5 alnn.laavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrly.ralgryeeAlelleealai 74 
                 ++n+ l++ ++  ++   Al+++eka+e+ ++         + +l  Lg++y +++ +  +A+ +  +a +i
  EFC36231.1 172 LWNHlLGNYYLLKQDNNSALKHYEKAVELDTA--------CVDSLAVLGDIYfHQMQDKTKAHLMWSRAFDI 235
                 56644*********************999944........56678889999855889999998776666665 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.23
      TPR_12  15 rlgrydeAlellekaleiarrl 36 
                  +++y  Ale +e+ l++++++
  EFC36231.1 365 TMQNYRAALEDCEHILRLISQA 386
                 58999**********9998765 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.038        43       3      50 ..      61     119 ..      59     124 .. 0.83
   2 ?   -2.6   0.1       7.6   8.5e+03      43      47 ..     152     156 ..     131     165 .. 0.53
   3 !    7.7   0.1    0.0045       5.1       5      44 ..     185     225 ..     181     249 .. 0.84
   4 ?    3.7   0.0     0.081        91      18      38 ..     269     289 ..     255     291 .. 0.83
   5 ?    0.2   0.0      0.99   1.1e+03      25      58 ..     317     350 ..     303     360 .. 0.79
   6 ?   -2.9   0.0       8.9   9.9e+03       4      18 ..     366     380 ..     364     385 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.038
      TPR_19   3 aegdyaeAlalleqalqe........dpk...naearllLAeallalgqldeAealLda 50 
                 ++ +y eA + + +a++         + +   ++ + l + + ++ lg ++ A ++ ++
  EFC36231.1  61 EAHKYGEAEKTFDKAMEMmikgsgfnYKDcitMSSLNLEMGRNYVHLGKVEHATQCFNK 119
                 6778999999999999887776666555588899999999**********999998876 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 7.6
      TPR_19  43 eAeal 47 
                  A+a+
  EFC36231.1 152 RAKAI 156
                 23333 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0045
      TPR_19   5 gdyaeAlalleqalqedpknaearllLAeallal.gqldeA 44 
                 +d  +Al+++e+a + d    + ++ L ++++ +  + ++A
  EFC36231.1 185 QDNNSALKHYEKAVELDTACVDSLAVLGDIYFHQmQDKTKA 225
                 78899**************************9985555555 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.081
      TPR_19  18 lqedpknaearllLAeallal 38 
                 l+ dp++ +  +l+A +l +l
  EFC36231.1 269 LKLDPEDVNSHYLMAVCLEEL 289
                 6789*************9775 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.99
      TPR_19  25 aearllLAeallalgqldeAealLdalpeedpdd 58 
                  e+  +  e l++l++++ A  +L+  ++ ++ +
  EFC36231.1 317 KELYRRFSEYLVELKNYNWALGVLNSGLKNAKEH 350
                 5677778888999***********9999888765 PP

  == domain 6  score: -2.9 bits;  conditional E-value: 8.9
      TPR_19   4 egdyaeAlalleqal 18 
                 +++y +Al+  e +l
  EFC36231.1 366 MQNYRAALEDCEHIL 380
                 788999988776655 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       2.9   3.3e+03      10      27 ..      58      75 ..      49      78 .. 0.75
   2 ?    2.6   0.0      0.29   3.3e+02       5      31 ..      98     124 ..      95     142 .. 0.82
   3 ?    4.6   0.0     0.064        72       6      33 ..     176     203 ..     170     214 .. 0.80
   4 ?    3.9   0.0       0.1   1.2e+02      13      43 ..     254     284 ..     243     285 .. 0.83
   5 ?    1.3   0.0      0.74   8.2e+02       3      40 ..     319     355 ..     317     358 .. 0.74
   6 ?   -0.6   0.0         3   3.3e+03      10      32 ..     355     377 ..     353     382 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 2.9
      TPR_14 10 allalGdpdeAiallrra 27
                +++++ ++ eA++ +++a
  EFC36231.1 58 FMREAHKYGEAEKTFDKA 75
                677888999999999887 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.29
      TPR_14   5 lalaeallalGdpdeAiallrralala 31 
                 l++++ + +lG+ + A ++++++++l 
  EFC36231.1  98 LEMGRNYVHLGKVEHATQCFNKVCELE 124
                 788999***************999864 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.064
      TPR_14   6 alaeallalGdpdeAiallrralalaPd 33 
                 +l+ ++l  +d   A++++++a++l+ +
  EFC36231.1 176 LLGNYYLLKQDNNSALKHYEKAVELDTA 203
                 6899999999*************98754 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.1
      TPR_14  13 alGdpdeAiallrralalaPddaeawlllaq 43 
                 +  ++++ +++l+  l+l+P+d   ++l+a 
  EFC36231.1 254 HEHNLEKTRKVLDIGLKLDPEDVNSHYLMAV 284
                 56789999**************988888875 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.74
      TPR_14   3 allalaeallalGdpdeAiallrralalaPddaeawll 40 
                 ++++  e+l +l ++  A+ +l+  l+ a ++ + ++l
  EFC36231.1 319 LYRRFSEYLVELKNYNWALGVLNSGLKNAKEHTV-YIL 355
                 556667899999**************97766544.433 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 3
      TPR_14  10 allalGdpdeAiallrralalaP 32 
                 ++l+++ ++  ++ +r+al+++ 
  EFC36231.1 355 LYLRQQFYEITMQNYRAALEDCE 377
                 57788888888888999999876 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.53   5.9e+02      15      34 .]      51      70 ..      43      70 .. 0.91
   2 ?   -0.2   0.0       1.5   1.7e+03      13      27 ..     131     145 ..     117     158 .. 0.78
   3 ?   -1.3   0.4       3.5     4e+03      17      32 ..     175     190 ..     174     192 .. 0.73
   4 ?    2.6   0.0      0.19   2.2e+02       2      30 ..     194     222 ..     193     226 .. 0.80
   5 !   10.0   0.0   0.00083      0.93       6      25 ..     269     288 ..     268     294 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.53
      TPR_17 15 aynnLAelllknGdlmtArq 34
                a+  +A ++++++++++A++
  EFC36231.1 51 AWISMACFMREAHKYGEAEK 70
                8999**************85 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.5
      TPR_17  13 adaynnLAelllknG 27 
                  +a+ +LA+l l  G
  EFC36231.1 131 GEAMAELAWLELDEG 145
                 579999**9998544 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 3.5
      TPR_17  17 nnLAelllknGdlmtA 32 
                 ++L++++l + d   A
  EFC36231.1 175 HLLGNYYLLKQDNNSA 190
                 6899999977776555 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.19
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlm 30 
                 y+ka+eld   +d++  L+ ++ ++ + +
  EFC36231.1 194 YEKAVELDTACVDSLAVLGDIYFHQMQDK 222
                 9*******999999999999998665544 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00083
      TPR_17   6 leldPnnadaynnLAelllk 25 
                 l+ldP ++++++++A++l++
  EFC36231.1 269 LKLDPEDVNSHYLMAVCLEE 288
                 899**************986 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       9.3     1e+04       9      22 ..      61      74 ..      60      75 .. 0.77
   2 !   11.4   0.0   0.00035      0.39       3      47 ..     177     218 ..     175     225 .. 0.91
   3 ?    4.8   0.0      0.04        45      17      47 ..     262     289 ..     256     293 .. 0.88
   4 ?   -2.9   0.1       9.9   1.1e+04       7      25 ..     356     374 ..     354     375 .. 0.54

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 9.3
      TPR_16  9 ragdyddAaaalea 22
                +a +y +A++ ++ 
  EFC36231.1 61 EAHKYGEAEKTFDK 74
                67899999998875 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00035
      TPR_16   3 laraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrq 47 
                 l++++l  +d   A++ +e a+++d    +++++l  lgd++++q
  EFC36231.1 177 LGNYYLLKQDNNSALKHYEKAVELD---TACVDSLAVLGDIYFHQ 218
                 789999999****************...99*************98 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.04
      TPR_16  17 aaaleaalkrdpssPdaaeAllllgdaalrq 47 
                 +++l++ lk+d   P+++ +++l ++++ ++
  EFC36231.1 262 RKVLDIGLKLD---PEDVNSHYLMAVCLEEL 289
                 6889999****...*************9876 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 9.9
      TPR_16   7 alragdyddAaaaleaalk 25 
                 +lr++ y+     ++aal+
  EFC36231.1 356 YLRQQFYEITMQNYRAALE 374
                 5555555555555555554 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0      0.11   1.3e+02      32      56 ..      97     121 ..      94     138 .. 0.82
   2 ?   -0.2   0.0         1   1.1e+03       3      40 ..     179     216 ..     177     220 .. 0.75
   3 ?    6.2   0.0      0.01        11       2      44 ..     249     291 ..     248     293 .. 0.91
   4 ?   -0.1   0.0      0.92     1e+03      43      58 ..     367     382 ..     361     392 .. 0.62

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.11
       TPR_9  32 rrdRGlllaqlGclsaAladLeayl 56 
                  ++ G+ +++lG ++ A ++++   
  EFC36231.1  97 NLEMGRNYVHLGKVEHATQCFNKVC 121
                 5788999*************98765 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1
       TPR_9   3 aiaireedweralavverllllaPddpeerrdRGllla 40 
                 + ++ ++d+  al+ +e  + l+   ++ +   G +++
  EFC36231.1 179 NYYLLKQDNNSALKHYEKAVELDTACVDSLAVLGDIYF 216
                 56788899999999999999988777766666666655 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.01
       TPR_9   2 kaiaireedweralavverllllaPddpeerrdRGlllaqlGc 44 
                 k+i   e++ e++ +v++  l l+P+d+  ++  +++l++l++
  EFC36231.1 249 KHIIKHEHNLEKTRKVLDIGLKLDPEDVNSHYLMAVCLEELEA 291
                 7788889999***********************9999999975 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.92
       TPR_9  43 GclsaAladLeaylal 58 
                  +++aAl+d e+ l+l
  EFC36231.1 367 QNYRAALEDCEHILRL 382
                 4566666666665543 PP

>> DUF1524  Protein of unknown function (DUF1524)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00073      0.82      73      98 ..     169     194 ..     154     204 .. 0.85
   2 ?    2.5   0.1      0.11   1.2e+02      22      55 ..     349     380 ..     331     394 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00073
     DUF1524  73 kreelvndlgNLtlltkslNsslsnk 98 
                  ++ + + lgN  ll++++Ns+l++ 
  EFC36231.1 169 IEQLWNHLLGNYYLLKQDNNSALKHY 194
                 55778899**************9964 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.11
     DUF1524  22 kklryilakelesalreedeeegeakkltiEHil 55 
                 +++ yil+  l+++++e ++++++a  ++ EHil
  EFC36231.1 349 EHTVYILY--LRQQFYEITMQNYRAALEDCEHIL 380
                 27789999..888899779*****99999****7 PP

>> FAT  FAT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   6.2   3.1e-05     0.035     136     306 ..      40     225 ..      12     284 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3.1e-05
                 CCCHCHCCS-STTCCCCCCCCHCHHHHCCSTTHHCCCCCHCTT..........TT.TSSCCCHHHHHHHCCHHHHHSSCC....HHHHCCTSSCCC... CS
         FAT 136 spiedllkgvkaemwlkfanlarksgrlslAekaLkelleedp.....eewlprappevvyaylKylwssgeqkealqkL....reftsellekke... 222
                 s ++d  + +++++w+++a   r++++++ Aek+  +++e        +++  ++++ + ++  +   + g+++ a q+     + ++s l++k e   
  EFC36231.1  40 SIKQD--EMYSIRAWISMACFMREAHKYGEAEKTFDKAMEMMIkgsgfNYKDCITMSSLNLEMGRNYVHLGKVEHATQCFnkvcELEVS-LMDKGEama 135
                 45555..7789*********************999988777665656666666888888888888888888876666665332433444.444433677 PP

                 .....SS-SS---.............HHHHCCCTCCCCCCCCCCCT.S...-SSCCHHHHCCHHCTCCCHSTTCCCCHHHHHCCHHHHHH CS
         FAT 223 .....elqsgleaq.keptnleeftkllarcylkkGewqealqkldwseekieeilqsysaateidpswykawhtwalfnfevvskeeeq 306
                      el +g +a+   ++ + e+ +++ +c      w + l++    +++++ +l++y +a+e+d  + +  + +++ +f+++++ ++ 
  EFC36231.1 136 elawlELDEGSDASlGRAKAIIEKLQQMTQCRRIEQLWNHLLGNYYLLKQDNNSALKHYEKAVELDTACVDSLAVLGDIYFHQMQDKTKA 225
                 777777777777777455555555555578888888899999998889999**********************************99765 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0       0.8   8.9e+02      12      31 ..      59      78 ..      54      84 .. 0.79
   2 ?   -2.7   0.0       5.6   6.3e+03       8      27 ..     100     119 ..      99     123 .. 0.77
   3 ?    6.7   0.1     0.006       6.7       8      30 ..     177     199 ..     174     201 .. 0.93
   4 ?   -2.1   0.0       3.7   4.2e+03       4      21 ..     207     225 ..     206     233 .. 0.74
   5 ?    0.8   0.1      0.43   4.8e+02      15      31 ..     366     382 ..     362     386 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.8
      TPR_10 12 lrqrgrydeAealleealai 31
                 r+  +y eAe+ +++a+++
  EFC36231.1 59 MREAHKYGEAEKTFDKAMEM 78
                56677999***999999987 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 5.6
      TPR_10   8 LanalrqrgrydeAeallee 27 
                 +++ + ++g+ + A + + +
  EFC36231.1 100 MGRNYVHLGKVEHATQCFNK 119
                 68889999999999887655 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.006
      TPR_10   8 LanalrqrgrydeAealleeala 30 
                 L+n++   ++ + A++++e+a++
  EFC36231.1 177 LGNYYLLKQDNNSALKHYEKAVE 199
                 9********************98 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 3.7
      TPR_10   4 slnNLanal.rqrgrydeA 21 
                 sl  L+ ++ +q+++ ++A
  EFC36231.1 207 SLAVLGDIYfHQMQDKTKA 225
                 6778999996777776666 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.43
      TPR_10  15 rgrydeAealleealai 31 
                 +++y +A++++e+ l++
  EFC36231.1 366 MQNYRAALEDCEHILRL 382
                 789999****9998876 PP

>> Mad3_BUB1_I  Mad3/BUB1 homology region 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.53     6e+02     101     122 ..      53      74 ..      32      82 .. 0.57
   2 ?   12.3   0.1   0.00011      0.13      77     124 .]     297     344 ..     277     344 .. 0.89
   3 ?   -3.3   0.1       7.8   8.7e+03      30      41 ..     365     377 ..     353     393 .. 0.46

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.53
                  HHHHHHHHHTT-HHHHHHHHHH CS
  Mad3_BUB1_I 101 eewAellekkgrfkeAeevyel 122
                  ++ A ++ +++++ eAe+ +++
   EFC36231.1  53 ISMACFMREAHKYGEAEKTFDK 74 
                  3344444444444444444443 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 0.00011
                  SS-HHHHHHHHHHHTTSTTBHHHHHHHHHHHHHTT-HHHHHHHHHHH. CS
  Mad3_BUB1_I  77 veepreifkflaskkiGtklalfYeewAellekkgrfkeAeevyelGi 124
                  v+++  if++ ++ + G +  ++Y++++e+l + ++++ A  v++ G+
   EFC36231.1 297 VQKELVIFHYAEAVRLGCEKKELYRRFSEYLVELKNYNWALGVLNSGL 344
                  478889*************************************99995 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 7.8
                  HHHH-TT.-T.TT CS
  Mad3_BUB1_I  30 ieesypq.sskes 41 
                  ++++y    ++++
   EFC36231.1 365 TMQNYRAaLEDCE 377
                  3333333222233 PP

>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0       1.6   1.8e+03       2      17 ..     132     146 ..     131     156 .. 0.74
   2 ?   10.9   0.1   0.00054      0.61      14      36 ..     176     200 ..     173     201 .. 0.79
   3 ?   -2.2   0.0       6.9   7.7e+03      21      33 ..     220     232 ..     206     233 .. 0.58

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 1.6
        Sel1   2 eAmyrLGmfylylnGl 17 
                 eAm+ L+ ++ +++G 
  EFC36231.1 132 EAMAELA-WLELDEGS 146
                 89*****.55557776 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00054
        Sel1  14 lnGl..gvpkDpekAiewyekAAeq 36 
                 l G    +++D ++A+++yekA e+
  EFC36231.1 176 LLGNyyLLKQDNNSALKHYEKAVEL 200
                 5566534899************887 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 6.9
        Sel1  21 kDpekAiewyekA 33 
                 +D+ kA+  + +A
  EFC36231.1 220 QDKTKAHLMWSRA 232
                 5777776666665 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.79   8.9e+02      68      81 ..      61      74 ..      43      76 .. 0.76
   2 ?    3.8   0.5     0.059        66      27      67 ..     175     216 ..     152     232 .. 0.67
   3 ?    3.6   0.4     0.069        77       4      44 ..     186     227 ..     183     266 .. 0.70
   4 ?    5.6   0.0     0.016        18      50      70 ..     270     290 ..     240     293 .. 0.83
   5 ?    1.0   0.5      0.43   4.9e+02      31      49 ..     325     343 ..     304     378 .. 0.63

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.79
                HTT-HHHHHHHH-S CS
      ANAPC3 68 kLkkyeeAiaaLek 81
                + +ky eA+++++k
  EFC36231.1 61 EAHKYGEAEKTFDK 74
                67999999999987 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.059
                 HHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHH CS
      ANAPC3  27 yllAlclylngqykrAyellrka.klnskslgcrylfAqcll 67 
                 +ll+  ++l ++ ++A++ ++ka +l+     ++ +++  ++
  EFC36231.1 175 HLLGNYYLLKQDNNSALKHYEKAvELDTACVDSLAVLGDIYF 216
                 566777777777777777777776666666666666655555 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.069
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-.HHHHHH CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclylngq.ykrAye 44 
                 + ++A+ ++e++++ +t   +++  l+  ++++ q  ++A+ 
  EFC36231.1 186 DNNSALKHYEKAVELDTACVDSLAVLGDIYFHQMQdKTKAHL 227
                 66899********999999999999*9999999775444443 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.016
                 SHHHC-HHHHHHHHHHHHHTT CS
      ANAPC3  50 klnskslgcrylfAqcllkLk 70 
                 kl++++ +++yl+A cl +L+
  EFC36231.1 270 KLDPEDVNSHYLMAVCLEELE 290
                 56889999********99885 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.43
                 HHHHHTT-HHHHHHHHHCT CS
      ANAPC3  31 lclylngqykrAyellrka 49 
                 + l ++++y+ A+ +l++ 
  EFC36231.1 325 EYLVELKNYNWALGVLNSG 343
                 4555566666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (413 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1356  (0.0756317); expected 358.6 (0.02)
Passed bias filter:                      628  (0.0350271); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.68u 0.30s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 2446.39
//
Query:       EFC36232.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.7    8.8  11.9       0.21   11.6   6.8    2.2  2  AT_hook   AT hook motif


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   6.8   1.2e-05      0.21       1      11 [.      22      32 ..      22      33 .. 0.90
   2 ?   -1.8   0.2      0.26   4.7e+03       7      10 ..     155     158 ..     155     159 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.2e-05
     AT_hook  1 kRkRGRPrKaa 11
                ++kRGRP+K++
  EFC36232.1 22 PKKRGRPPKNS 32
                79*******97 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.26
     AT_hook   7 PrKa 10 
                 PrK+
  EFC36232.1 155 PRKT 158
                 9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1307  (0.0728987); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1067.63
//
Query:       EFC36233.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-23   83.8   0.0    3.4e-23   82.6   0.0    1.6  1  DIOX_N        non-haem dioxygenase in morphine synthesis N-te
    1.9e-23   82.9   0.0    3.2e-23   82.1   0.0    1.3  1  2OG-FeII_Oxy  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> DIOX_N  non-haem dioxygenase in morphine synthesis N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.6   0.0   3.8e-27   3.4e-23       1      84 [.       9     104 ..       9     130 .. 0.87

  Alignments for each domain:
  == domain 1  score: 82.6 bits;  conditional E-value: 3.8e-27
      DIOX_N   1 iPvidlspl..........sddedraavaeqlreAcrevGffyvvnhgvpeelidelfeaareFFalPeeeKekl..akspsfrGysrlgeektdg 84 
                 +P+id+ p+          +d+++ a+v++q+++Ac+++Gffy++nhg++eel+d+l++  r FF+ P++ K+++  ++s+ +rGy  lg e t+ 
  EFC36233.1   9 LPIIDIGPIihttdsdgnyQDEQAAANVIKQIGQACERFGFFYIKNHGIDEELVDKLMSEGRSFFNKPLDYKNQYhmKNSKVYRGYFELGGELTKL 104
                 799****99998887776545566899************************************************977888***********9975 PP

>> 2OG-FeII_Oxy  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.1   0.0   3.5e-27   3.2e-23       7     101 .]     137     237 ..     132     237 .. 0.82

  Alignments for each domain:
  == domain 1  score: 82.1 bits;  conditional E-value: 3.5e-27
                   EEEE-S-....-----....---EEEEEESSSEEEEEEE-TT---EEEE..TEEEE----TTEEEEEE-HHHHHHTTS-S----EEE----GTGSEE CS
  2OG-FeII_Oxy   7 lnyypph....pdpev....ilglgahtdaslltillqddvgglevfkd..gkwlrvppvdnslivniGdallflsngryksvlHrVlpvnegerRv 93 
                   l +yp      +         +g+g h d+++lt+l qd+vgglev++   g+w++ pp +++++vniGd+l+ +++gryk v+HrV++ + + +R+
    EFC36233.1 137 LFHYPSDpnakF---EngeeRFGVGKHQDYGCLTLLKQDNVGGLEVEDRstGEWISAPPLEKTFVVNIGDMLERWTCGRYKAVPHRVKNLTNQ-DRL 229
                   555543332332...0344689************************7445688***********************************66665.5** PP

                   EEEEEE-- CS
  2OG-FeII_Oxy  94 siayfiep 101
                   s+ +f+ p
    EFC36233.1 230 SAPFFFDP 237
                   *****865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       352  (0.019633); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 1872.37
//
Query:       EFC36234.1  [L=721]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-07   30.9   4.3    9.2e-07   29.1   4.3    1.9  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.1   4.3   5.1e-11   9.2e-07       8     117 ..     587     700 ..     583     701 .. 0.94

  Alignments for each domain:
  == domain 1  score: 29.1 bits;  conditional E-value: 5.1e-11
                 SHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHHHHHHHHHH CS
         RGS   8 dqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke......qpsrklfeeaqeevfel 100
                 ++++ +lFr+++ ++ + en  F + v e k++ +++  ++  ++I +++l p s+ e+ni++  re+  +++ek+      +++ ++++e+  ev   
  EFC36234.1 587 NEDLIQLFRTYCSKSLALENYMFIEMVMESKRK-SENISIENLQRIHKQFLIPYSAYEVNIPSGARERYVDNFEKVtknnetKTNIQILDEIMLEVEAN 684
                 56799****************************.9999999**********************************99999999999************* PP

                 HHHHHHHHHHTSHHHHH CS
         RGS 101 lekdsypkFlkselylr 117
                 l++  +++F ++  +l+
  EFC36234.1 685 LKS-TFNRFERTSEFLE 700
                 975.7999999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (721 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1144  (0.0638072); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.28s 00:00:00.99 Elapsed: 00:00:00.46
# Mc/sec: 4704.07
//
Query:       EFC36235.1  [L=996]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-16   60.1   0.0    3.2e-16   59.0   0.0    1.6  1  PLD_C     Phospholipase D C terminal
    2.7e-15   55.8   0.1    1.8e-06   27.9   0.0    2.8  2  PLDc      Phospholipase D Active site motif
    8.4e-11   41.9   0.1    2.3e-06   27.5   0.0    3.5  3  PLDc_2    PLD-like domain
  ------ inclusion threshold ------
        7.3    6.6   8.6         20    5.2   8.6    1.7  1  DUF999    Protein of unknown function (DUF999)


Domain annotation for each model (and alignments):
>> PLD_C  Phospholipase D C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.0   0.0   7.2e-20   3.2e-16       5      71 ..     921     985 ..     918     986 .. 0.92

  Alignments for each domain:
  == domain 1  score: 59.0 bits;  conditional E-value: 7.2e-20
       PLD_C   5 eePesleCvrkvnkiaeenWkayaseeveelkghLlkYPvevdkdGkvkelpgaetfPDtkakvlGs 71 
                 e+P +l   r++ ++ae+nW++y+see++ +++hL++YPv vd dG+v++    + fPDt+++v G 
  EFC36235.1 921 EDPLDLFTQRRIDEVAEDNWERYTSEEFRPMRSHLMHYPVIVDVDGSVSARV--KYFPDTRGRVEGV 985
                 6777777889***************************************998..9*********996 PP

>> PLDc  Phospholipase D Active site motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   0.0   4.1e-10   1.8e-06       2      28 .]     546     581 ..     545     581 .. 0.96
   2 !   25.2   0.0   2.9e-09   1.3e-05       2      28 .]     845     871 ..     844     871 .. 0.94

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 4.1e-10
                 TBEE---EEEETTT.........EEEEE---SSHHH CS
        PLDc   2 mgthHqKivivDdr.........vafvGgaNLcdgr 28 
                 +++hHqK++i D++         vafvGg++L++gr
  EFC36235.1 546 VFSHHQKTLICDKYvpekkkrsiVAFVGGLDLTKGR 581
                 689******************************998 PP

  == domain 2  score: 25.2 bits;  conditional E-value: 2.9e-09
                 TBEE---EEEETTTEEEEE---SSHHH CS
        PLDc   2 mgthHqKivivDdrvafvGgaNLcdgr 28 
                 m+ +H+K+ i+Dd++ +vG+aN++ ++
  EFC36235.1 845 MIYVHSKMAIFDDEYIIVGSANINERS 871
                 8899********************996 PP

>> PLDc_2  PLD-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0   0.00085       3.8       4     104 ..     452     580 ..     449     590 .. 0.69
   2 ?    2.7   0.0     0.024   1.1e+02       2      25 ..     696     718 ..     695     753 .. 0.80
   3 !   27.5   0.0   5.2e-10   2.3e-06      80     115 ..     846     881 ..     793     893 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00085
      PLDc_2   4 liksAkksidiatyyf.............vsdreildallkaakrgvkvrilldskkd..........dagavde.aslkelkellleagvevrvfetl 78 
                 ++++Ak+ i+i   ++             + +r++ + l+++a++gv v ++l +++           d  a ++ ++ +  + l +++g    v    
  EFC36235.1 452 AMENAKQIIYITGWSLnpnirlkrdsddpKESRTLGELLIDKANEGVSVFLILWNETGsniasnmdtgDGEAINYfRNTRVVAILSRRSGYSGLV---- 546
                 678888888888888888888888877777788889999*************9987767766666555222222202222233333333333222.... PP

      PLDc_2  79 lgslHaKlylidgk.........tvivGSsNltkr 104
                   s H+K+++ d+          +++vG+  ltk 
  EFC36235.1 547 -FSHHQKTLICDKYvpekkkrsiVAFVGGLDLTKG 580
                 .356********555556788889999*9999986 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.024
      PLDc_2   2 iqliksAkksidiatyyfvsdrei 25 
                 i li++A++ i+i ++yf   +++
  EFC36235.1 696 ISLIQKAQRFIYIENQYF-CGSAF 718
                 789***************.44333 PP

  == domain 3  score: 27.5 bits;  conditional E-value: 5.2e-10
      PLDc_2  80 gslHaKlylidgktvivGSsNltkrgldlnlElnvv 115
                   +H+K++++d+++ ivGS+N+++r++++++++ + 
  EFC36235.1 846 IYVHSKMAIFDDEYIIVGSANINERSMSGDRDSEIS 881
                 468************************999987765 PP

>> DUF999  Protein of unknown function (DUF999)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   8.6    0.0045        20      42     138 ..     155     260 ..     128     264 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0045
      DUF999  42 kpqkdklniktnkikeflndlftefskfhn......syypdgristrsklrwvlliiwsiiivlaidkkfev...keflsiwinenrfyseiwgpiaiy 131
                 +p k   ni+++ +k+ ++ +f  + +f         y+ d  +     +rw+ +i    ii+l i+ +  +   ke+l i i  n   s i+g i++y
  EFC36235.1 155 HPGKTIENIHAKDVKKSVKSFFRHLPHFIVyffvilIYFRDVVLNFFRFSRWPTIIFLPFIIILGIQIHAWIiwfKEILNIVIFYNILISVIFGSIVLY 253
                 46777778888877777777777666654311111146677777777889***************99875443449999999***************** PP

      DUF999 132 vcllvll 138
                  + ++l+
  EFC36235.1 254 FGDWILV 260
                 *999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (996 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       998  (0.055664); expected 358.6 (0.02)
Passed bias filter:                      532  (0.0296726); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.88u 0.29s 00:00:01.17 Elapsed: 00:00:00.53
# Mc/sec: 5703.16
//
Query:       EFC36236.1  [L=528]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.8e-10   39.2   0.0    1.6e-09   38.2   0.0    1.5  1  MACPF     MAC/Perforin domain


Domain annotation for each model (and alignments):
>> MACPF  MAC/Perforin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2   0.0   9.1e-14   1.6e-09      24     209 .]     190     353 ..     186     353 .. 0.86

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 9.1e-14
                 EEEEEEEEEEEEEES--....B-HHHHHHHHTS-SS--SSTHHH.HHHHHHHH-SEEEEEEEEEEEEEEEEEEEHHHHHHTT--HHHHHHHHHHHHTS- CS
       MACPF  24 iiskskcslyqftlkrsnklklseeFlkalneLpsnydsaaedtpyieffekYGTHvitsvtlGGkivyvlkldkeeveklkkkkedclsasagasing 122
                 +i  ++ ++++ t+ +s  l++++eF++ +  Lp+++d +     y+++++++G  ++ts+++GG ++ +  +++++   ++ +  +   ++++++i  
  EFC36236.1 190 FIVDAQKQIFTHTV-QSLGLQVTDEFQQIIDILPDQMDWDL----YMQVINSFGDSIATSIKYGGVVDMTASVRSCYNDPQMLQYLS---QELQFTI-- 278
                 67777778888888.7789******************9999....*****************************9998777666655...6776666.. PP

                 SHHHHHHHHHHHHTT-SS-HHHH---EEEEEESS-GGG----HHHHHHHHHHTTTS-EEEEEEEEEGGGGS-TT-HHHHHHHHHHHH CS
       MACPF 123 kvslkgkkknssetkekksssqesessktlviGGepeseddksktyseWaesvkenpmpIklelvPisellkeeekkeslkkaleeY 209
                     +g++++s+     + +  +++ s++++ GG+p     + +++++   +   np+p+ ++  Pi   ++   k+ ++kk +e Y
  EFC36236.1 279 ----DGSSDVSK---LPNGYIRYHKVSQVDIVGGNP-----QISNIRQRTATFAANPVPVTFDTIPIWRAFPNGVKQANMKKVYESY 353
                 ....55555544...3445667799**********9.....666899999*******************999999********9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (528 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       751  (0.0418874); expected 358.6 (0.02)
Passed bias filter:                      625  (0.0348597); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.44
# Mc/sec: 3582.25
//
Query:       EFC36237.1  [L=399]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-26   90.9  11.9      1e-05   25.3   0.1    7.2  7  NHL             NHL repeat
    3.6e-05   24.0   0.2        3.4    8.0   0.0    4.2  3  ANAPC4_WD40     Anaphase-promoting complex subunit 4 WD40 dom
    0.00054   19.6   0.1       0.33   10.5   0.0    3.4  3  SGL             SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.041   13.8   0.1      0.082   12.8   0.1    1.5  1  Endonuclease_7  Recombination endonuclease VII
       0.07   13.3   0.1         33    4.8   0.0    3.4  4  Arylesterase    Arylesterase


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.018        65      16      25 ..      88      97 ..      87     100 .. 0.88
   2 !   25.3   0.1   2.9e-09     1e-05       3      28 .]     115     141 ..     114     141 .. 0.97
   3 !   15.9   0.0   2.8e-06    0.0099       1      28 []     163     191 ..     163     191 .. 0.96
   4 ?   -0.4   0.0      0.41   1.5e+03       1      10 [.     232     241 ..     232     242 .. 0.82
   5 !    8.8   0.2    0.0005       1.8      15      26 ..     253     264 ..     251     266 .. 0.89
   6 !   19.4   0.2   2.1e-07   0.00074       9      28 .]     302     321 ..     300     321 .. 0.89
   7 !   18.7   0.0   3.5e-07    0.0013       7      27 ..     376     397 ..     374     398 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.018
                EEEECCCTEE CS
         NHL 16 yVaDsenhrv 25
                +++D+ nhrv
  EFC36237.1 88 LISDYSNHRV 97
                689******9 PP

  == domain 2  score: 25.3 bits;  conditional E-value: 2.9e-09
                 SEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvqvF 28 
                 +PhG++vd   G+++ +D++ h ++vF
  EFC36237.1 115 HPHGICVDeVKGELLATDCNDHLIKVF 141
                 7*************************9 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 2.8e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 fn P+ +++d +n+  +V+D++n+r+q+F
  EFC36237.1 163 FNAPSAICLDlKNDCMFVSDYGNNRIQKF 191
                 7889************************9 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.41
                 BSSEEEEEEE CS
         NHL   1 fnyPhGvavd 10 
                 +  P+G+++d
  EFC36237.1 232 LDKPWGLSLD 241
                 578****997 PP

  == domain 5  score: 8.8 bits;  conditional E-value: 0.0005
                 EEEEECCCTEEE CS
         NHL  15 iyVaDsenhrvq 26 
                 +yV+D++n++++
  EFC36237.1 253 LYVCDTKNNCIR 264
                 8*********97 PP

  == domain 6  score: 19.4 bits;  conditional E-value: 2.1e-07
                 EETTTEEEEEECCCTEEEEE CS
         NHL   9 vdsnGdiyVaDsenhrvqvF 28 
                 ++++++++++Ds+nh+v++F
  EFC36237.1 302 IVDGNRLLISDSGNHCVKIF 321
                 459****************9 PP

  == domain 7  score: 18.7 bits;  conditional E-value: 3.5e-07
                 EEEE.TTTEEEEEECCCTEEEE CS
         NHL   7 vavd.snGdiyVaDsenhrvqv 27 
                  a+d   G++yV+D+ nhr+q+
  EFC36237.1 376 MALDsFKGELYVSDCSNHRIQI 397
                 5666558**************8 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0   0.00095       3.4      45      82 ..      79     117 ..      39     122 .. 0.74
   2 !    5.8   0.0    0.0047        17      49      76 ..     125     152 ..     123     172 .. 0.90
   3 ?    3.2   0.1      0.03   1.1e+02      53      81 ..     253     282 ..     249     290 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00095
  ANAPC4_WD40  45 aWkpdgklLava.ysdgevrlldaesgkvvhslsvksek 82 
                  + +  gkl+ ++ ys+ +v +++ae+g  v++++vk+ +
   EFC36237.1  79 HKSSLGKLMLISdYSNHRVMICKAEDGAFVSEIHVKHPH 117
                  55566777665428889****************999876 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0047
  ANAPC4_WD40  49 dgklLavaysdgevrlldaesgkvvhsl 76 
                  +g+lLa  ++d  ++++ +e+g+ v+++
   EFC36237.1 125 KGELLATDCNDHLIKVFRIETGQYVRNI 152
                  799********************99887 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.03
  ANAPC4_WD40  53 Lava.ysdgevrlldaesgkvvhslsvkse 81 
                  L v  ++++ +rl+d+ +g+ + +   +++
   EFC36237.1 253 LYVCdTKNNCIRLFDSTNGNFIGNAISNAK 282
                  55441678899*********9988776665 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   9.3e-05      0.33     133     218 ..     113     200 ..      90     217 .. 0.78
   2 ?    1.4   0.0     0.053   1.9e+02     147     176 ..     252     284 ..     249     339 .. 0.62
   3 ?    3.5   0.0     0.012        44     149     210 ..     341     398 ..     327     399 .] 0.79

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 9.3e-05
         SGL 133 ltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge.gepDGlavDa.eGnvwvAvwgggkvvrfdpd.Gklie 218
                 ++ p G+++++ +  l+ +D   + i ++ + ++g+++ n  +   +++g+ ++p  +++D  +++++v  +g++++++f+   G+ i+
  EFC36237.1 113 VKHPHGICVDEVKGELLATDCNDHLIKVFRI-ETGQYVRNIGKGCGTQNGQfNAPSAICLDLkNDCMFVSDYGNNRIQKFKYStGEFIK 200
                 6667788888888888888888888888888.466668888887777777766688888888888888888888888888877777766 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.053
         SGL 147 tlYlaDsltrkiwaydvdae...ggklsnrrvf 176
                  lY++D+ +++i  +d       g+ +sn++++
  EFC36237.1 252 VLYVCDTKNNCIRLFDSTNGnfiGNAISNAKTV 284
                 578888888888877764431113444444444 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.012
         SGL 149 YlaDsltrkiwaydvdaeggklsnrrvf.adlkkgegepDGlavDa.eGnvwvAvwgggkvvrf 210
                 Y++Ds  r+ + y+  +  + ++n + f ++++ +     G+a+D+ +G+++v   ++++++ +
  EFC36237.1 341 YYVDSIGRHNYIYE--EVPSFIQNIKEFpIEFSHNV----GMALDSfKGELYVSDCSNHRIQII 398
                 77777777655444..45566888888888888888....9*****************999876 PP

>> Endonuclease_7  Recombination endonuclease VII
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   2.3e-05     0.082      15      63 ..      86     137 ..      76     154 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.3e-05
                     HHTT---TTSE-TTT--EEETT.S--EEEEE-TTT--...EE.EEEHHHHH.H CS
  Endonuclease_7  15 rkalleaqggkCaiCqerekek.tkalavDHdHktgk..vRg.llCgsCNtal 63 
                      + + +  +++ +iC++ e +  + +++v H H  +   v+g ll + CN  l
      EFC36237.1  86 LMLISDYSNHRVMICKA-EDGAfVSEIHVKHPHGICVdeVKGeLLATDCNDHL 137
                     556778899999****8.55555*************99977648999***875 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.29     1e+03      53      82 ..     113     142 ..     108     146 .. 0.83
   2 ?    4.8   0.0    0.0093        33      36      82 ..     146     192 ..     135     195 .. 0.80
   3 ?   -2.7   0.0       1.9     7e+03      38      58 ..     251     271 ..     232     277 .. 0.68
   4 ?    3.6   0.1     0.021        75      47      82 ..     364     399 .]     341     399 .] 0.81

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.29
  Arylesterase  53 lssanGInidadkkyiyvadilresihvmk 82 
                   ++ + GI +d +k  +  +d  ++ i v++
    EFC36237.1 113 VKHPHGICVDEVKGELLATDCNDHLIKVFR 142
                   67899********99999999999776655 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0093
  Arylesterase  36 tavvYyspsevkvvasglssanGInidadkkyiyvadilresihvmk 82 
                   +++v   ++   ++  +++++  I +d ++  ++v+d  ++ i  +k
    EFC36237.1 146 GQYVRNIGKGCGTQNGQFNAPSAICLDLKNDCMFVSDYGNNRIQKFK 192
                   55666666677788889********************9999997766 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.9
  Arylesterase  38 vvYyspsevkvvasglssanG 58 
                    v y+ +  ++ +  ++s nG
    EFC36237.1 251 HVLYVCDTKNNCIRLFDSTNG 271
                   455666666666666666666 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.021
  Arylesterase  47 kvvasglssanGInidadkkyiyvadilresihvmk 82 
                   k+    +s   G+ +d+ k  +yv+d  ++ i ++k
    EFC36237.1 364 KEFPIEFSHNVGMALDSFKGELYVSDCSNHRIQIIK 399
                   44445688899*******************998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 2322.98
//
Query:       EFC36238.1  [L=928]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (928 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       687  (0.0383178); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 5547.10
//
Query:       EFC36239.1  [L=170]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-24   86.6   0.2    1.6e-24   86.1   0.2    1.1  1  UQ_con    Ubiquitin-conjugating enzyme
  ------ inclusion threshold ------
       0.01   16.1   0.2      0.015   15.6   0.2    1.3  1  RWD       RWD domain


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.1   0.2   1.8e-28   1.6e-24       1     139 [.      31     164 ..      31     165 .. 0.89

  Alignments for each domain:
  == domain 1  score: 86.1 bits;  conditional E-value: 1.8e-28
                 HHHHHHHHHHHSTTTTEEEEEEETTEECEEEEEEEB.TTSTTTTEEEEEEEE--TTTTTS--EEEESST-SCTTBETTSBB-CGGGSTTT--TTSHHHH CS
      UQ_con   1 rlqkelkelakkkpsgisaklvddenlfewkvlikgpedtpYeggvFklelefpedYPlkpPkvkfvtkifHPnvdksGevcldiLkeekWspaltles 99 
                 r+q+el++l+k+  + +  +    ++l++++++i++ ++++++++  ++el +p++YP+k+P++ ++t+i+HPn+d++G v l++     ++p++ l++
  EFC36239.1  31 RIQQELENLDKEWLDHLVIAD--TNKLDKMTITIVP-SEGIWKNHPHEFELIIPHEYPHKAPNIICKTRIWHPNIDENGLVDLNLRY--LFKPTMGLKD 124
                 677888876555555444443..369********99.9**********************************************855..5********* PP

                 HHHHHHHHHHS--TTS-SSHHHHHHHHHTHHHHHHHHHHH CS
      UQ_con 100 vllsiqsLlaepnpesplnkeaakllkkdreeykkkvkey 139
                  ++ ++ L+ epnp +p n +a++++ +++e +k+k+++y
  EFC36239.1 125 FFVGVLFLMLEPNPLDPQNYKAGRQFLDEPEGFKQKANNY 164
                 ************************************9887 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.6   0.2   1.6e-06     0.015       4      84 ..      33     103 ..       6     116 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.6e-06
                 HHHHHHHHHHSTTTCCCCHT--EE--S-EEEEEEECECCCC....TT-CEEEEEEEEE-SSTTSS--EEEEEECCSS-HHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         RWD   4 eqEleaLesIypdefevienenysikleikikldededeedsefeekkkpslkleiklpeeYPeeaPiislsstenlpkeq 84 
                 +qEle L+    d ++  ++++     +++i++ ++e        + k+++ ++e   p eYP++aP i  ++  + p+ +
  EFC36239.1  33 QQELENLDKEWLDHLVIADTNKLD---KMTITIVPSE-------GIWKNHPHEFELIIPHEYPHKAPNIICKTRIWHPNID 103
                 455555555555555444433333...3444444443.......46789999999999**********9988877555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       455  (0.0253779); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1054.48
//
Query:       EFC36240.1  [L=1191]
Description: hypothetical protein NAEGRDRAFT_76086 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-08   33.4   2.3    4.7e-05   23.9   0.0    4.4  4  Ank_2     Ankyrin repeats (3 copies)
    5.2e-07   29.8   0.6    5.5e-05   23.4   0.0    4.0  4  Ank_5     Ankyrin repeats (many copies)
    1.1e-05   25.4   0.6        5.2    8.0   0.0    5.6  4  Ank_3     Ankyrin repeat
    1.3e-05   25.6   3.2      0.048   14.3   0.2    5.0  7  Ank_4     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.066   13.5   0.1       0.27   11.6   0.1    2.1  1  DUF3677   Protein of unknown function (DUF3677)
        3.1    8.5   9.0      0.081   13.6   2.4    1.7  2  Mif2_N    Kinetochore CENP-C fungal homologue, Mif2, N-termin


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.15   4.4e+02      12      79 ..     389     481 ..     377     494 .. 0.57
   2 ?    4.0   0.0     0.026        77       8      37 ..     537     567 ..     514     596 .. 0.80
   3 ?   -1.8   0.0       1.7   5.1e+03      64      73 ..     907     916 ..     831     926 .. 0.68
   4 !   23.9   0.0   1.6e-08   4.7e-05      12      73 ..    1036    1111 ..    1028    1121 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.15
       Ank_2  12 lvklLlegadpn...kngktaLhyAakngnl....eivklLle.h............ad..ndgrtpLhyAarsg...hleivklLlekgadi 79 
                 ++k+L e +++    + + ++L + +kn+n     +i+++L   +            ++  ++++++Lh+ +       +++v  L++ g++i
  EFC36240.1 389 TCKILFEQSELPlvfDGEINPLLWIIKNNNSsqlpDIIEFLFTlNpslvtlgdangvVNgdEKNMNILHLYITTCktiEERVVSSLINIGCNI 481
                 556665333332222234778888888774433345788888641344455554444335455667777766552233356666776445554 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.026
       Ank_2   8 gnlelvklLl.egadpn..k.ngktaLhyAakng 37 
                 g   + +lL+ +g+d+n  + +g+ +L+y+ k+ 
  EFC36240.1 537 G---IACLLItHGVDANlvDeDGNLPLIYFLKEK 567
                 5...888898999999987469999999998864 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.7
       Ank_2  64 ghleivklLl 73 
                 +++eiv++L+
  EFC36240.1 907 TNEEIVQILI 916
                 2344444444 PP

  == domain 4  score: 23.9 bits;  conditional E-value: 1.6e-08
       Ank_2   12 lvklLlegadpnkngktaLhyAakngnle...........ivklLleh........adndgrtpLhyAarsghleivklLl 73  
                  l+++L  ++  n++g+t+Lh  ++n n e           ++k++ +h        +dn+g+tpL++A++sg  ++++ +l
  EFC36240.1 1036 LINWLT-SK--NTEGRTVLHMICQNCNSEnydtksdmlndLIKYISSHnrndifnlQDNEGKTPLFHAVESG--NFIETFL 1111
                  455555.22..2379*********9555456666665555689999878878867666*************9..5777766 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.87   2.6e+03       9      25 ..     445     461 ..     423     464 .. 0.78
   2 !   23.4   0.0   1.8e-08   5.5e-05       4      55 ..     510     562 ..     507     563 .. 0.90
   3 ?   -0.4   0.0      0.55   1.6e+03      12      26 ..    1043    1058 ..    1039    1061 .. 0.76
   4 ?    0.3   0.0      0.32   9.6e+02      43      53 ..    1087    1097 ..    1080    1109 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.87
       Ank_5   9 vnrldgggntpLhvAak 25 
                 v + d++ +++Lh+ + 
  EFC36240.1 445 VVNGDEKNMNILHLYIT 461
                 45668888899998875 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 1.8e-08
       Ank_5   4 hg.padvnrldgggntpLhvAak.ygaadvvrlLlargadlnltdsrGltaldl 55 
                  g +++    ++++ + Lh  ++   a+ +++lL+ +g+d+nl d++G+++l +
  EFC36240.1 510 FGlSINDVKFEKNW-NLLHKLINlTKASGIACLLITHGVDANLVDEDGNLPLIY 562
                 56677777888888.************************************987 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.55
       Ank_5   12 ldgggntpLhvAak.y 26  
                  ++ +g t+Lh+ +  +
  EFC36240.1 1043 KNTEGRTVLHMICQnC 1058
                  678899****988744 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.32
       Ank_5   43 nltdsrGltal 53  
                  nl+d++G+t+l
  EFC36240.1 1087 NLQDNEGKTPL 1097
                  56666666665 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.44   1.3e+03       4      23 ..     408     431 ..     406     436 .. 0.79
   2 ?    4.1   0.2     0.031        94       2      30 ..     522     550 ..     521     551 .. 0.91
   3 ?    5.2   0.0     0.013        40       1      16 [.    1046    1061 ..    1046    1085 .. 0.68
   4 !    8.0   0.0    0.0017       5.2       1      20 [.    1092    1109 ..    1092    1118 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.44
       Ank_3   4 tpLhlAarsgnl....eivkfLle 23 
                 +pL + ++++n     +i++fL+ 
  EFC36240.1 408 NPLLWIIKNNNSsqlpDIIEFLFT 431
                 699999999999776669999986 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.031
       Ank_3   2 GetpLhlAarsgnle.ivkfLlenkgadvn 30 
                 ++++Lh  +  ++ + i+++L+  +g+d n
  EFC36240.1 522 NWNLLHKLINLTKASgIACLLIT-HGVDAN 550
                 6899**********98999****.9***98 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.013
       Ank_3    1 nGetpLhlAarsgnle 16  
                  +G+t Lh+ + ++n e
  EFC36240.1 1046 EGRTVLHMICQNCNSE 1061
                  69***********994 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0017
       Ank_3    1 nGetpLhlAarsgnleivkf 20  
                  +G tpL++A++sgn+  ++ 
  EFC36240.1 1092 EGKTPLFHAVESGNF--IET 1109
                  599***********9..554 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0         1     3e+03       8      39 ..     381     411 ..     371     429 .. 0.64
   2 ?   -2.1   0.0       2.1   6.3e+03      14      41 ..     468     495 ..     467     495 .. 0.88
   3 ?   -2.4   0.0       2.8   8.3e+03      23      41 ..     510     528 ..     507     530 .. 0.84
   4 !    6.6   0.1    0.0041        12      19      43 ..     541     564 ..     522     571 .. 0.80
   5 ?   -3.5   0.0       5.9   1.8e+04      11      24 ..     906     919 ..     902     923 .. 0.77
   6 ?    3.2   0.0     0.048   1.4e+02      24      48 ..    1036    1060 ..    1012    1064 .. 0.72
   7 !   14.3   0.2   1.6e-05     0.048       2      48 ..    1048    1106 ..    1047    1110 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1
       Ank_4   8 aaisgrlelvrlLlekgadinaqdnrsGetal 39 
                 + + ++++++++L+e+   +    +++ +++l
  EFC36240.1 381 LSELSKVKTCKILFEQSELPLVF-DGEINPLL 411
                 33489999******875545555.55444444 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2.1
       Ank_4  14 lelvrlLlekgadinaqdnrsGetalhi 41 
                 +++v +L++ g +i ++++  G++++hi
  EFC36240.1 468 ERVVSSLINIGCNIKYVCPTTGNNLIHI 495
                 678999997799**99999999999997 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 2.8
       Ank_4  23 kgadinaqdnrsGetalhi 41 
                 +g +in ++ +  +++lh+
  EFC36240.1 510 FGLSINDVKFEKNWNLLHK 528
                 4899999999999999996 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0041
       Ank_4  19 lLlekgadinaqdnrsGetalhiAa 43 
                 lL+ +g+d n + +++G+ +l++ +
  EFC36240.1 541 LLITHGVDANLV-DEDGNLPLIYFL 564
                 78889*******.*********976 PP

  == domain 5  score: -3.5 bits;  conditional E-value: 5.9
       Ank_4  11 sgrlelvrlLlekg 24 
                 + ++e+v++L+ ++
  EFC36240.1 906 FTNEEIVQILIGSK 919
                 67999999999765 PP

  == domain 6  score: 3.2 bits;  conditional E-value: 0.048
       Ank_4   24 gadinaqdnrsGetalhiAakrgnv 48  
                   +++  ++n +G+t lh+ +++ n 
  EFC36240.1 1036 LINWLTSKNTEGRTVLHMICQNCNS 1060
                  46788889999******99998875 PP

  == domain 7  score: 14.3 bits;  conditional E-value: 1.6e-05
       Ank_4    2 ltaLhyaai...sgrlel........vrlLlek.gad.inaqdnrsGetalhiAakrgnv 48  
                  +t+Lh+ ++   s+++++        ++++ ++ + d  n q +++G t+l +A+  gn+
  EFC36240.1 1048 RTVLHMICQncnSENYDTksdmlndlIKYISSHnRNDiFNLQ-DNEGKTPLFHAVESGNF 1106
                  899999999777555555555555666666677678856666.999*********99985 PP

>> DUF3677  Protein of unknown function (DUF3677)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   9.1e-05      0.27      24      64 ..    1038    1076 ..    1012    1090 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.1e-05
     DUF3677   24 iwlqnpKLsreaqeLLlslcvncntqssekdsevlsrLlkl 64  
                   wl+++    e  ++L ++c ncn+++ +  s++l+ L+k 
  EFC36240.1 1038 NWLTSKN--TEGRTVLHMICQNCNSENYDTKSDMLNDLIKY 1076
                  5665544..78899*************************96 PP

>> Mif2_N  Kinetochore CENP-C fungal homologue, Mif2, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.6       4.1   1.2e+04      36      73 ..      34      75 ..      21      88 .. 0.45
   2 ?   13.6   2.4   2.7e-05     0.081      59     131 ..    1114    1184 ..    1099    1190 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.1
      Mif2_N 36 Peks....ekengeeeeeeededesgeedmdleessgpepad 73
                P+k+    ++e+ +e   ++++++++  d ++ es +++ + 
  EFC36240.1 34 PKKKvkktTEERIKEVAGDSQDNDDEMVDDEVGESGKINTKR 75
                444432211111112222222222222344455554444444 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 2.7e-05
      Mif2_N   59 edmdleessgpepadllsgrressrlplprarSPaktslksparrnsslaresqeerpsssPsraasq.ktvkr 131 
                  +d+++++++g + +d+l+++++    p  + + P+ ts  s++rr+++ +  ++e+r sss ++++s+ kt++r
  EFC36240.1 1114 SDISIQNNKGEKIQDILNEEQKVLFAPYLQVKKPTTTSK-SSNRRKKNQS--EDENRASSSEDEGKSKkKTATR 1184
                  89*******************999999999****98887.5555555555..3556666666666655244433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1512  (0.0843326); expected 358.6 (0.02)
Passed bias filter:                      564  (0.0314574); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.04u 0.36s 00:00:01.40 Elapsed: 00:00:00.58
# Mc/sec: 6229.33
//
Query:       EFC36241.1  [L=926]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.1e-18   65.2   2.3    2.1e-17   63.4   0.5    2.8  2  RGS         Regulator of G protein signaling domain
    3.4e-09   37.1   0.1    7.3e-09   36.0   0.1    1.6  1  CHASE4      CHASE4 domain
    1.5e-05   25.3   0.0    5.2e-05   23.5   0.0    2.0  2  HAMP        HAMP domain
  ------ inclusion threshold ------
       0.49   10.4   3.4        2.2    8.3   3.4    2.1  1  Holin_BlyA  holin, BlyA family


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.46   2.1e+03      17      42 ..     134     159 ..     131     213 .. 0.72
   2 !   63.4   0.5   4.8e-21   2.1e-17       2     116 ..     781     895 ..     780     897 .. 0.96

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.46
                 HHHHHTTCT.HHHHHHHHHHHHHTSSH CS
         RGS  17 eFlesefse.enlsFwlaveefkkake 42 
                 +F+++e +  + ++F+l +  ++ + +
  EFC36241.1 134 DFCKKEDETsKWMKFYLCCLSLRVK-T 159
                 69999888879999**999999887.3 PP

  == domain 2  score: 63.4 bits;  conditional E-value: 4.8e-21
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqeevfel 100
                 ++++++d+  r+lF+ F  se s en++F++++e++k+ ++ +++ +  +e++n+yl p+sp  ln++kk++e+  k+++    + +lf+++++ +  +
  EFC36241.1 781 FNRIFKDPHWRELFKVFAASELSAENVHFLEDIETYKSLSKTRDRAALLEEMVNKYLLPESPYPLNVSKKTVETEIKKITSGYGQLDLFDKIESIIKLM 879
                 899*********************************************************************9988888888***************** PP

                 HHHHHHHHHHTSHHHH CS
         RGS 101 lekdsypkFlkselyl 116
                   +d +++Fl+s++++
  EFC36241.1 880 VVNDTFSRFLSSKIFR 895
                 **************97 PP

>> CHASE4  CHASE4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.0   0.1   1.6e-12   7.3e-09       2     136 ..     205     385 ..     204     386 .. 0.70

  Alignments for each domain:
  == domain 1  score: 36.0 bits;  conditional E-value: 1.6e-12
      CHASE4   2 lqaeldqlerllkdwavWDdtyafvqdrdpdyiesnlgd....etletlgldlvlfldadgklvy............................dqengq 68 
                 l ++++ +++ ++d a WDd+y  +++++++ +++ l+       ++  g+++ + + ++g+                               d  ng+
  EFC36241.1 205 LFDDFKFISEKVYDFASWDDSYSIMKTENTTIADKMLDLyfscAYMKRAGINFSIMYYPNGTFFNgracfdmwkipefpdelkalstsffqtdDNYNGK 303
                 6788899999*********************666555553333889**************999944444455555555555555555544444333333 PP

      CHASE4  69 .........ekllseaeee.............s.grsgllkldggpalvaaapIltsegegpsrGtlvfgryldeallsrlseltlldlel 136
                                                 s + +  +    +++l +a pI + +++++ +G+++ gry++++l +++s +t+ + ++
  EFC36241.1 304 ivtssafqaV--------FtprrnlaqlfssnSqVPANSFVNATNIILAVALPI-QPNNNSDQNGVFLYGRYMTQSLSDDISVRTQYCTTF 385
                 5555555440........044433444444432455566666777899999***.445679************************988776 PP

>> HAMP  HAMP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       3.3   1.5e+04      34      44 ..     283     293 ..     281     293 .. 0.88
   2 !   23.5   0.0   1.2e-08   5.2e-05       6      52 ..     517     564 ..     516     565 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3.3
                 SSHHHHHHHHH CS
        HAMP  34 rDEiGeLaraf 44 
                 +DE+ +L  +f
  EFC36241.1 283 PDELKALSTSF 293
                 7******9998 PP

  == domain 2  score: 23.5 bits;  conditional E-value: 1.2e-08
                 THHHHHHHHHHHHHHTT.TBTSSTCCTTSSSHHHHHHHHHHHHHHHHH CS
        HAMP   6 ilrPLrrLaraarriaa.GdldtrlpvsgrDEiGeLarafNaMldrLr 52 
                 +lr++ ++ +++++i + +d+++r+p sg DE+G+L + +N+Ml +L+
  EFC36241.1 517 VLRRILKIGSTVKSITKtNDISKRVPNSGFDELGRLCKDINHMLMALE 564
                 69**************736***************************98 PP

>> Holin_BlyA  holin, BlyA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   3.4   0.00048       2.2       9      41 ..     497     529 ..     492     533 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00048
  Holin_BlyA   9 lLitldeiKLiilgiFvvllvlgvllllKPllk 41 
                 +Li +  + Li+++iFv  +vl  +l +   +k
  EFC36241.1 497 VLIAIVFTLLIAVMIFVECVVLRRILKIGSTVK 529
                 688999999*************99998866655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (926 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1544  (0.0861175); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.90u 0.39s 00:00:01.29 Elapsed: 00:00:00.59
# Mc/sec: 4702.62
//
Query:       EFC36242.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       437  (0.0243739); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 1028.58
//
Query:       EFC36243.1  [L=172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       579  (0.032294); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1015.73
//
Query:       EFC36244.1  [L=1376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.5e-48  162.6   0.0      2e-47  161.2   0.0    1.7  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    2.9e-08   34.0   4.6    2.9e-08   34.0   4.6    2.3  2  RGS            Regulator of G protein signaling domain
     0.0047   16.4   0.3      0.011   15.2   0.3    1.6  1  HNOBA          Heme NO binding associated
  ------ inclusion threshold ------
      0.015   15.6   0.0      0.081   13.2   0.0    2.3  2  PAS_9          PAS domain
      0.038   14.0   0.9      0.093   12.8   0.2    2.0  2  CCD            WisP family C-Terminal Region
       0.15   10.1   0.0       0.25    9.4   0.0    1.2  1  DUF5393        Family of unknown function (DUF5393)
       0.26   11.9   3.7        1.9    9.1   0.1    2.9  2  DUF2523        Protein of unknown function (DUF2523)


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  161.2   0.0   7.7e-51     2e-47       3     182 ..     766     943 ..     765     944 .. 0.98

  Alignments for each domain:
  == domain 1  score: 161.2 bits;  conditional E-value: 7.7e-51
  Guanylate_cyc   3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveske 98 
                    +e++d++t lF+d+vgft++ss  ++ e+v+lLn++++ fd+ ++  +++k+ktiGday +v gl+  +++h +k++ +a++ml+ +++ ++++++
     EFC36244.1 766 SEKFDDCTCLFSDMVGFTKMSSGLTAYELVQLLNSIINGFDSYITPLGLEKIKTIGDAYFCVGGLN-GQTDHPEKVITFAIHMLSVINNYNTKNNT 860
                    5789**************************************************************.9**************************** PP

  Guanylate_cyc  99 glkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182
                    +l++rvGihtGpv+ag+iG++k+ yd+wG+t  +A+ mes g++g+iq s++tye    + fe++e++ +e+k    + ty+l+
     EFC36244.1 861 KLNIRVGIHTGPVIAGCIGQQKFAYDLWGETLIIANLMESKGVPGRIQASRKTYERVY-DIFEFEEIKGIELKPSVLVNTYLLK 943
                    *********************************************************9.9*************98889999886 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       5.2   1.3e+04      41      57 ..      91     107 ..      63     111 .. 0.60
   2 !   34.0   4.6   1.1e-11   2.9e-08       2     118 .]     974    1094 ..     973    1094 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 5.2
                 SHHHHHHHHHHHHHHHH CS
         RGS  41 keqeelkkkakeIyney 57 
                 ++q+++++ ++++y+++
  EFC36244.1  91 DDQNKINAIVHAMYKTF 107
                 45556666666666665 PP

  == domain 2  score: 34.0 bits;  conditional E-value: 1.1e-11
                  HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-..HHHHHHHHHHHCSS...STTTTTTHHH CS
         RGS    2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnid..kklreelekrleke...qpsrklfeea 93  
                  ++++++d ++ + F++F  ++++ + ++F++ ++e+ ++   + + ++a+++++ yl++ +pk l+++  k+ +   + ++++    +  ++lfe+ 
  EFC36244.1  974 FSKIIQDRSLIQGFKDFFTDSEKVNIINFYELCQEYVSSPIPSLRYNMAENMVRDYLEETAPKRLQLKyvKNAFGPFQMKFKDCnddNCPSDLFENF 1070
                  899************************************9999999*****************9988622455544444444436669999****** PP

                  HHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS   94 qeevfellekdsypkFlkselylrl 118 
                  q+ +++ l++  +p F+ks+ ++++
  EFC36244.1 1071 QNLCLKALRE-EFPAFIKSKNFNKF 1094
                  ********97.6*********9986 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.3   4.3e-06     0.011     194     221 .]     730     758 ..     711     758 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 4.3e-06
       HNOBA 194 smke.leeekkrtdeLLysmiPkevAerL 221
                 ++k  l ee+k++d+LL +++P+++A+rL
  EFC36244.1 730 KHKLlLAEERKKSDNLLLNILPERIAQRL 758
                 4443389********************98 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       4.5   1.2e+04      35      59 ..      81     105 ..      67     116 .. 0.70
   2 ?   13.2   0.0   3.2e-05     0.081      49     103 ..     674     726 ..     659     727 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4.5
       PAS_9  35 sitdlfvtdpeanerlraaleqgrk 59 
                  +++ fv++++++++++a++ ++ k
  EFC36244.1  81 LFWQYFVSNEDDQNKINAIVHAMYK 105
                 3445558999999999888877654 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.2e-05
       PAS_9  49 rlraaleqgrkkerevevvlirkngetfwvlltaspvkdddgelvgiivilrDit 103
                  l+++l + ++  ++ e++ +rkng+ + v +++s ++ ++++l+    +lrDit
  EFC36244.1 674 LLDKLLVATESAGEHLELEAVRKNGSSLSVGVSVSVFHHENKNLIT--MLLRDIT 726
                 455555555557899*******************************..******9 PP

>> CCD  WisP family C-Terminal Region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.2   3.7e-05     0.093      46     115 ..     138     208 ..     129     221 .. 0.75
   2 ?   -2.1   0.0       1.5   3.8e+03      89     129 ..    1055    1095 ..    1046    1096 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.7e-05
         CCD  46 wpfrklfgsrseapssttnatgntsgktrvkrdtpttppe.hplksvndqitkvtdavnnfqksvltslkn 115
                 + frk++ s+  +ps   +atg+ s  t  +r t            vndq    t+ v         ++k 
  EFC36244.1 138 FLFRKVMTSKKSSPSLNKEATGEDSKSTISNRSTQNPEVTkSQQVQVNDQAHEYTEKVYREAINTKFTMKL 208
                 579*************************9999986644330345579***999999886544443334444 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.5
         CCD   89 ksvndqitkvtdavnnfqksvltslknff.tyltdtahlkfl 129 
                  k  nd+    +d  +nfq+  l +l++ f +++      kfl
  EFC36244.1 1055 KDCNDDNC-PSDLFENFQNLCLKALREEFpAFIKSKNFNKFL 1095
                  55666543.478999*********987552666667777776 PP

>> DUF5393  Family of unknown function (DUF5393)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   9.8e-05      0.25     344     387 ..     667     710 ..     659     714 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 9.8e-05
     DUF5393 344 laqwydrlldrlllateaaGvrldaylksakstavkqGeavssa 387
                 l ++ d lld+ll+ate+aG +l+        ++ + G +vs +
  EFC36244.1 667 LREYVDELLDKLLVATESAGEHLELEAVRKNGSSLSVGVSVSVF 710
                 67899*****************9876666677778888888876 PP

>> DUF2523  Protein of unknown function (DUF2523)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.1   0.00074       1.9      18      58 ..     405     447 ..     398     448 .. 0.93
   2 ?    2.4   0.6     0.093   2.4e+02      32      79 ..     613     660 ..     592     661 .. 0.92

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00074
     DUF2523  18 vaLglgfvtyagidalidgl..isllqsalnglpssvlqllgl 58 
                 v Lgl++v++  +  l+++l  + ++ s+++++p +++++l++
  EFC36244.1 405 VLLGLLVVATVIVIVLLATLniKEKIISLFSKIPKDIVGILNI 447
                 569*****************99******************985 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.093
     DUF2523  32 alidglisllqsalnglpssvlqllgllgfgeAlniilsAvvtrlalq 79 
                  ++++l s++++++ +l+++ +  +   +   Al++ ++A+v  l+++
  EFC36244.1 613 VMFSTLLSAISAKIHSLGDDLVDPIVGVQTKLALGVFSGAFVLILIIA 660
                 6889999***********************************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1041  (0.0580624); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.97u 0.31s 00:00:01.28 Elapsed: 00:00:00.50
# Mc/sec: 8254.79
//
Query:       EFC36245.1  [L=681]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.3e-10   38.8   0.0    2.7e-09   37.0   0.0    2.1  2  PAS             PAS fold
    9.1e-08   32.3   0.6    3.6e-07   30.4   0.1    2.3  2  PAS_9           PAS domain
    0.00013   22.5   0.4    0.00074   20.0   0.0    2.5  2  PH              PH domain
     0.0032   17.7   3.7     0.0054   17.0   0.1    2.7  2  RGS             Regulator of G protein signaling domain
      0.008   16.2   0.0      0.016   15.2   0.0    1.5  1  PAS_8           PAS domain
  ------ inclusion threshold ------
      0.086   12.9   8.5       0.25   11.4   8.2    1.9  1  CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein C
      0.089   13.3   0.0       0.19   12.2   0.0    1.5  1  NYN             NYN domain
       0.11   12.7   0.6       0.49   10.7   0.0    2.1  2  PAS_4           PAS fold
        3.9    6.8  14.4        1.9    7.8  11.7    1.8  2  SelP_N          Selenoprotein P, N terminal region


Domain annotation for each model (and alignments):
>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       5.4   1.1e+04      38      75 ..     133     170 ..     131     191 .. 0.68
   2 !   37.0   0.0   1.4e-12   2.7e-09       3      95 ..     227     322 ..     225     331 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 5.4
                 HHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCC CS
         PAS  38 reevlgkslldliheeddaelaelleqlleqgeesrag 75 
                 ++ ++gks ++l++ e +   +e l  ++ ++ + +++
  EFC36245.1 133 ANNLCGKSNSMLLFVENSVAEKETLVVVAPSADQYNMW 170
                 56788888888888887766666666666555555555 PP

  == domain 2  score: 37.0 bits;  conditional E-value: 1.4e-12
                 HHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEEEE CS
         PAS   3 lraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevrasp 95 
                 +++++++++dp+++ + +g+i++vN aae ++ ++  e++g+++  l+++   a+ ++++ ++++ ++++r+  + +++    ++gr++ +e+ +  
  EFC36245.1 227 ISNLIDAMTDPTVIANDKGIIIGVNGAAEAMFEWKHIELIGENVKVLMPT-VFAKYHDEFINNYKKTRKQRMIGKPRNVlgktKNGRTFTVEISVGE 322
                 5789*****************************************99975.58899***************999999999***********998866 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.4   0.1   1.8e-10   3.6e-07       2      85 ..     236     323 ..     235     339 .. 0.92
   2 ?   -1.5   0.1       1.5   2.9e+03      53      53 ..     529     529 ..     465     593 .. 0.56

  Alignments for each domain:
  == domain 1  score: 30.4 bits;  conditional E-value: 1.8e-10
       PAS_9   2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlf..vtdpeanerlraaleqgrk..kerevevvlirkngetfwvlltaspv 85 
                 d+++i n++g i+ +N aa+ ++  ++ e++g +++ l+  v++++++e+++++ ++ ++  + + ++v   +kng+tf v++++  +
  EFC36245.1 236 DPTVIANDKGIIIGVNGAAEAMFEWKHIELIGENVKVLMptVFAKYHDEFINNYKKTRKQrmIGKPRNVLGKTKNGRTFTVEISVGEI 323
                 6789999***666*********************************************99***********************99765 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.5
       PAS_9  53 a 53 
                 +
  EFC36245.1 529 Q 529
                 2 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.0   3.7e-07   0.00074       4     101 ..      55     175 ..      52     178 .. 0.58
   2 ?   -2.0   0.1       2.5   5.1e+03      62      72 ..     501     511 ..     460     552 .. 0.53

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 3.7e-07
                 EEEEEEETSSSSCSEEEEEEEEETTE.EEEESST..................TCTTESSEEEEEESTTEEEEEEEC.....................TT CS
          PH   4 eGwLlkkgsgkkkswkkrwfvLkdse.llyyknd..................ksekdkepkgsislsncevvevva.....................te 62 
                 +G L+ + +g+ ++wkk +f+L+++  ++ +k +                                       +++                     ++
  EFC36245.1  55 SGELVMRQNGFFGRWKKFFFTLTKDGaFVKFKTSdfhtpmqtyfliyshnlvC------------------DGHKNdkynmvtteaafesptlpqpaNN 135
                 7887766666666**********666688888883333333333333333432..................2222233333333333333333466333 PP

                 SSSSTSEEEEEESTSSS..TEEEEEEESSHHHHHHHHHHHH CS
          PH  63 dpkrkfcfelriverng..srtyllqasseeerkeWikaiq 101
                  +++ ++  l +ve++   ++t++  a+s++  ++W++a++
  EFC36245.1 136 LCGKSNSM-LLFVENSVaeKETLVVVAPSADQYNMWMRAFE 175
                 33333333.35665555667******************987 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.5
                 TSSSSTSEEEE CS
          PH  62 edpkrkfcfel 72 
                 e  k k++f l
  EFC36245.1 501 EFNKLKYKFLL 511
                 22233333332 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.6      0.41   8.1e+02      29      91 ..     482     541 ..     469     565 .. 0.66
   2 !   17.0   0.1   2.7e-06    0.0054      40      98 ..     602     663 ..     572     670 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.41
                 HHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTH CS
         RGS  29 sFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfe 91 
                 + ++ ve+++k+ ++    ++++++  ++l    +k+++i ++  e+l ++le++++s +l+e
  EFC36245.1 482 KIYKRVEKIEKR-SRTLKDNEFNKLKYKFL--LLEKQIKIMEEENEKLFTQLETQRESIELLE 541
                 446666666666.66666666777777777..6666666666666666666666655555544 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 2.7e-06
                 S.....SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHH CS
         RGS  40 a.....keqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqeevf 98 
                 a     k++ ++ k a+eI++e++++++++ + ++++l ++l ++l +  p++++f ++  e+ 
  EFC36245.1 602 AsyslhKQHFKMEKNAREIFDEFFSSHAKHPVILSEELADTLLSHLDT--PTSHMFTMILYEII 663
                 1444448899999***********************************..*******9988776 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   8.1e-06     0.016       3      51 ..     227     276 ..     225     288 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 8.1e-06
       PAS_8   3 lralfesspdgiavvdlgdrivdvNqaalellGys.adlkgellgqllpv 51 
                 + +l++++ d+ +++++ + i+ vN aa+ ++ ++  +l+ge + +l+p 
  EFC36245.1 227 ISNLIDAMTDPTVIANDKGIIIGVNGAAEAMFEWKhIELIGENVKVLMPT 276
                 6789*********9984457*************99777777766665554 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   8.2   0.00013      0.25      18      64 ..     501     547 ..     480     553 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00013
  CENP-F_leu_zip  18 kadsLkdkvenLerelemseenqekvileaEtskaevetlkeeieel 64 
                     + ++Lk k + Le++++++ee++ek+ ++ Et+++ +e l+ e + +
      EFC36245.1 501 EFNKLKYKFLLLEKQIKIMEEENEKLFTQLETQRESIELLERESRVM 547
                     3356999**********************************998877 PP

>> NYN  NYN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   9.4e-05      0.19       2      77 ..     553     616 ..     552     621 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 9.4e-05
         NYN   2 vavfiDgenlpvpakgkevdyrklleeirskgelvraraygn...wedeeqnkfqdalsstgikvkhkplkkrggsgkk 77 
                 v+vfiD++n p        +y+++l++++++g+l + r+  +          k+ ++++s+ +++++ ++k      k+
  EFC36245.1 553 VSVFIDMANSPS-------SYESILKWATKNGKLNHVRCCKSiidF----SAKYSKSMKSASYSLHKQHFKM----EKN 616
                 89********99.......799*****************9994432....3666677788888887777643....444 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.9       1.2   2.4e+03      60      80 ..      26      45 ..      11      48 .. 0.64
   2 ?   10.7   0.0   0.00024      0.49       2      47 ..     232     277 ..     231     295 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.2
       PAS_4 60 legeepiefleelllpgeerh 80
                +++ ++++ +++++++g ++h
  EFC36245.1 26 ATTTHHHHNHHHHHHGG-HHH 45
                44556677777777744.443 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00024
       PAS_4   2 dslpdalavldpdgrvlyaNaaaaelfgappeellGktlaellpee 47 
                 d++ d++++ ++ g ++ +N aa+++f +   el+G+ +  l+p+ 
  EFC36245.1 232 DAMTDPTVIANDKGIIIGVNGAAEAMFEWKHIELIGENVKVLMPTV 277
                 7889*********************************999777764 PP

>> SelP_N  Selenoprotein P, N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8  11.7   0.00097       1.9     188     212 ..      24      48 ..       3      61 .. 0.50
   2 ?   -2.8   0.0       1.7   3.3e+03     180     190 ..     376     386 ..     330     421 .. 0.50

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00097
      SelP_N 188 hshkqghkhhekhghhHkekeelse 212
                 ++ + +h+hh++h+hhH+++++ +e
  EFC36245.1  24 QQATTTHHHHNHHHHHHGGHHHEQE 48 
                 3333444444444444444333333 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.7
      SelP_N 180 ektehehahsh 190
                 + +e+e++++h
  EFC36245.1 376 SFNEKEKEDEH 386
                 12222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (681 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1657  (0.0924201); expected 358.6 (0.02)
Passed bias filter:                      598  (0.0333538); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.81u 0.32s 00:00:01.13 Elapsed: 00:00:00.51
# Mc/sec: 3981.58
//
Query:       EFC36246.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.21   11.6   0.5       0.61   10.2   0.5    1.7  1  Hol_Tox   Putative Holin-like Toxin (Hol-Tox)
       0.43   10.2   2.9       0.78    9.4   2.9    1.4  1  DUF4131   Domain of unknown function (DUF4131)


Domain annotation for each model (and alignments):
>> Hol_Tox  Putative Holin-like Toxin (Hol-Tox)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.5   6.8e-05      0.61      29      50 ..      47      68 ..      44      70 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 6.8e-05
     Hol_Tox 29 vsealQliLaFGtFilallalV 50
                +++al +iL  GtF ++l +l 
  EFC36246.1 47 IFDALFVILWLGTFAMSLATLL 68
                79***************99985 PP

>> DUF4131  Domain of unknown function (DUF4131)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   2.9   8.7e-05      0.78       5      76 ..      55     126 ..      49     134 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 8.7e-05
     DUF4131   5 lalvllalllllllllllllrrrprrrvllllllllllallgfalrapqpnandlsqlles...gqeviveGvva 76 
                 l+l ++a+ l++lll  ++      +  +++ l l + +++ ++++ + +na+ l +++     ++  + +G + 
  EFC36246.1  55 LWLGTFAMSLATLLLPHWR---FGIPYLIWSSLTLGFSFGYALFWSPYMRNATALKSYTGAgaaDHLAFSTGIIG 126
                 3333333333333333333...466666889999999999999999******9*999998777777776666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       509  (0.0283898); expected 358.6 (0.02)
Passed bias filter:                      254  (0.014167); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.44
# Mc/sec: 1099.31
//
Query:       EFC36247.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-06   27.7   3.6    2.6e-06   26.9   3.6    1.4  1  YdjM        LexA-binding, inner membrane-associated putative 
  ------ inclusion threshold ------
      0.013   14.9   1.1      0.023   14.1   0.2    1.8  2  Ceramidase  Ceramidase
      0.038   13.8   0.5       0.55   10.0   0.0    2.1  2  Claudin_2   PMP-22/EMP/MP20/Claudin tight junction
      0.081   12.6   3.6        3.2    7.4   3.6    2.3  1  DUF4184     Domain of unknown function (DUF4184)
       0.32    9.8   7.4        1.9    7.2   7.3    1.9  1  COX1        Cytochrome C and Quinol oxidase polypeptide I
        1.5    9.1   0.0        1.5    9.1   0.0    2.9  4  DPM3        Dolichol-phosphate mannosyltransferase subunit 3 


Domain annotation for each model (and alignments):
>> YdjM  LexA-binding, inner membrane-associated putative hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   3.6   8.6e-10   2.6e-06      69     147 ..      86     192 ..      85     217 .. 0.74

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 8.6e-10
        YdjM  69 ftHSllflallalvlllllrlfgrsa........lrlglllllgvlsHlllDlltk.yGvpllwPfskkkvrlsllfiiidplltll............ 146
                  tHS+l++++l+lv +++++ + +            + ++++lg++sH +lD l   +    ++P+s++k  l++  ++++ ++ l             
  EFC36247.1  86 YTHSILGVFILSLVYSMIYWIYSKVSgkkkvdslGKIVFIMFLGAFSHWILDFLVHrKDLLAFFPISNWKGGLGWWDYPNEYVFCLEtflvllgcvgil 184
                 59*********************999*****998777888*************998577888*****98888888877777755555666666666666 PP

        YdjM 147 .......s 147
                        +
  EFC36247.1 185 igkakrgQ 192
                 66665443 PP

>> Ceramidase  Ceramidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.2   7.8e-06     0.023     137     193 ..      88     139 ..      63     143 .. 0.90
   2 ?   -1.8   0.0      0.56   1.7e+03     110     125 ..     199     214 ..     167     238 .. 0.50

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 7.8e-06
  Ceramidase 137 qvafalltvlvllrsiyliekkvdksdeaakkevkklallgliifllgfliWnlDnl 193
                 + +++++++ +++++iy+i +kv     + kk+v +l  + +i+fl +f  W+lD l
  EFC36247.1  88 HSILGVFILSLVYSMIYWIYSKV-----SGKKKVDSLGKIVFIMFLGAFSHWILDFL 139
                 56788999999999999997777.....789************************75 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.56
  Ceramidase 110 vllgvlltalavvvtl 125
                  ll+++l + + v+ +
  EFC36247.1 199 FLLSFGLYLSISVILT 214
                 3333333222222222 PP

>> Claudin_2  PMP-22/EMP/MP20/Claudin tight junction
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   0.00018      0.55      54     132 ..      52     130 ..      42     142 .. 0.81
   2 ?    1.9   0.1     0.054   1.6e+02      96     147 ..     169     218 ..     166     236 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00018
   Claudin_2  54 enktelfvvltqasnpfekkeeeivsisatsllalarfvqvlliLslvlivlavvlgllallkqsvlllkaagilflla 132
                 +++ ++ +++    +   +   + + + +++ ++++ ++  ++iLslv +++ ++   ++  k+ + l k ++i+fl a
  EFC36247.1  52 DSCPYKPWICGEYATYNVDLMRKGRVTPMDFSIDYTHSILGVFILSLVYSMIYWIYSKVSGKKKVDSLGKIVFIMFLGA 130
                 45556666666555566666677788889999**********************************9999999999854 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.054
   Claudin_2  96 liLslvlivlavvlgllallkqsvlllkaagilfllagvlgllavvvfiesv 147
                 + L  +l++l+ v +l++  k+ + l  a++   l  g+ + ++v+++   v
  EFC36247.1 169 FCLETFLVLLGCVGILIGKAKRGQKLTSARFL--LSFGLYLSISVILTYVAV 218
                 55666888999999999999999977766632..333555555555444443 PP

>> DUF4184  Domain of unknown function (DUF4184)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   3.6    0.0011       3.2      96     188 ..     113     203 ..      70     256 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0011
     DUF4184  96 rkslkallvvvvsaliGaatHvlwDsfTHedgwfvrlipvlqssvagdvplykl.lqhgstllGlvviivvlvrllrraksksekeklavlaav 188
                 +k++ +l  +v  +++Ga++H ++D + H ++ + + +p+ + +  g + +++   ++++ l +++v++ ++  l  +ak+ ++ + +++l+ +
  EFC36247.1 113 KKKVDSLGKIVFIMFLGAFSHWILDFLVHRKDLL-AFFPISNWK--GGLGWWDYpNEYVFCLETFLVLLGCVGILIGKAKRGQKLTSARFLLSF 203
                 35566666677778999********999999865.455543333..456666552456666666666666666666665555555555555444 PP

>> COX1  Cytochrome C and Quinol oxidase polypeptide I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   7.3   0.00064       1.9      50     171 ..      93     217 ..      87     252 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00064
                 HHHHHHCHHHHHHHHHHHHCTSS-S-HHHHHHHHHHHHHHHHHHHHHHH..CS............S-STTTTTTTC.SHHHHHHHHHHHHHHHHHHHHH CS
        COX1  50 lfatpfilgfgnylvplllgardlafprlnalsfwlvvlgvvllllsll..ga............attgwteYaplsevdlwllglllvvvssllgain 134
                 +f+++++  ++++++ +++g++++ +  l ++ f+++++++  ++l +l   +            +  gw+ Y+   +  ++ l  +lv    llg++ 
  EFC36247.1  93 VFILSLVYSMIYWIYSKVSGKKKVDS--LGKIVFIMFLGAFSHWILDFLvhRKdllaffpisnwkGGLGWWDYP---NEYVFCLETFLV----LLGCVG 182
                 45555678899999999987776554..6999999999999999999988622456667777777899999999...455588888888....778888 PP

                 HHHHHHHHHHHTT-CCGS-HHHHHHHHHHHHHHHHCH CS
        COX1 135 fivtilkrrapgmtvaklplfvwavlatailillalp 171
                 +++  +kr ++ +t a+  l  ++++  + +il +++
  EFC36247.1 183 ILIGKAKRGQK-LTSARFLL-SFGLYLSISVILTYVA 217
                 77777777655.44443332.3444444444444443 PP

>> DPM3  Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.2   6.7e+03      12      25 ..      25      38 ..      16      60 .. 0.57
   2 ?    0.2   0.6       0.3     9e+02       8      54 ..      90     133 ..      86     142 .. 0.59
   3 ?    9.1   0.0   0.00049       1.5      43      75 ..     197     230 ..     173     235 .. 0.82
   4 ?   -2.8   0.1       2.5   7.4e+03      46      59 ..     245     258 ..     244     266 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.2
        DPM3 12 llllalwlalllrl 25
                l+l++ w+ +++ +
  EFC36247.1 25 LILSTQWIDVVFYT 38
                34444444443333 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.3
        DPM3   8 lalallllalwlalllrlvslplskvqdevvpvlPlwalvlfGaysl 54 
                 ++ +++l+ ++ +++    +++ +k++d++     +++++ +Ga+s 
  EFC36247.1  90 ILGVFILSLVYSMIYWIYSKVSGKKKVDSL---GKIVFIMFLGAFSH 133
                 556677777888888777766645555554...33445555555554 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00049
        DPM3  43 lwalvlfGays.latlgygvltfndcpeaakeLq 75 
                   +l++fG+y+ + ++++ v+ f d ++ +++  
  EFC36247.1 197 ARFLLSFGLYLsISVILTYVAVFDDAKKHQENVD 230
                 5689******725567889******999887765 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 2.5
        DPM3  46 lvlfGayslatlgy 59 
                 lvlf  +  atlgy
  EFC36247.1 245 LVLFTYFVSATLGY 258
                 78888888888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       556  (0.0310112); expected 358.6 (0.02)
Passed bias filter:                      293  (0.0163422); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1655.18
//
Query:       EFC36248.1  [L=171]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.034   14.5   0.0        0.9    9.9   0.0    2.2  2  FtsH_ext  FtsH Extracellular
      0.098   12.4   0.0       0.15   11.9   0.0    1.2  1  COQ7      Ubiquinone biosynthesis protein COQ7


Domain annotation for each model (and alignments):
>> FtsH_ext  FtsH Extracellular
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.023   2.1e+02      77      96 ..      23      42 ..      13      53 .. 0.83
   2 ?    9.9   0.0    0.0001       0.9      48     100 ..      69     127 ..      65     135 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.023
    FtsH_ext 77 tystptlgsvesleekLeea 96
                ++  ++l++++s++++L++ 
  EFC36248.1 23 NVLLHSLPQNPSFTSRLVQY 42
                567899***********986 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0001
    FtsH_ext  48 vvqestis......alirrptgdgvsttkkgnstttystptlgsvesleekLeealksk 100
                 +v+++++        l+ r +g+ +++ +k +  ++++++t+++ + + ++L++  k++
  EFC36248.1  69 QVVDNSQDkyivgsGLLLRKNGKYFFMQNKASIGKVMFIFTILELDVFKRELDDEVKEL 127
                 4454444446677778889999*******************************998886 PP

>> COQ7  Ubiquinone biosynthesis protein COQ7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   1.6e-05      0.15     116     143 ..     122     149 ..     107     159 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.6e-05
        COQ7 116 eeedkelleiikqfrddEleHldtAven 143
                 +e ++ l++ +kqf  +EleHl+ A++ 
  EFC36248.1 122 DEVKELLQKCVKQFEGEELEHLKDAING 149
                 3667778899***************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1074.50
//
Query:       EFC36249.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      0.003   17.6   0.5      0.012   15.6   0.0    2.3  2  UB2H            Bifunctional transglycosylase second domain
  ------ inclusion threshold ------
       0.15   12.6   1.0       0.28   11.8   0.1    1.9  2  CHAP            CHAP domain
        1.7    7.8  32.2          2    7.5  32.2    1.2  1  SOG2            RAM signalling pathway protein
        4.2    7.3  18.8        5.1    7.0  18.8    1.1  1  TFIIA           Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> UB2H  Bifunctional transglycosylase second domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   1.0       1.5   6.8e+03      24      45 ..      74      95 ..      67      97 .. 0.78
   2 !   15.6   0.0   2.7e-06     0.012       7      35 ..     241     269 ..     236     272 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.5
        UB2H 24 vsnvtrpGeyavsgnriellrR 45
                +sn +rp +y+++ ++ + +rR
  EFC36249.1 74 TSNNRRPTSYNRRPTTTTNNRR 95
                4888999999999888777776 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 2.7e-06
        UB2H   7 lsaaqleqeLellgYrkvsnvtrpGeyav 35 
                  sa+++  +L+++gY+kvs + +pG++++
  EFC36249.1 241 GSAKDFGSWLQKMGYQKVSGPMQPGDVQI 269
                 5899*********************9875 PP

>> CHAP  CHAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       1.8   7.9e+03      37      47 ..     150     159 ..     124     176 .. 0.58
   2 ?   11.8   0.1   6.3e-05      0.28       9      69 ..     217     283 ..     209     292 .. 0.63

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.8
                 EEEEEECSTBS CS
        CHAP  37 yknqanvgsst 47 
                 +++++n++s +
  EFC36249.1 150 FSQYRNTQS-K 159
                 333333333.2 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 6.3e-05
                 SHHHHHHHHHHHHS..........SSSSSSECTCCHHC.........EEEEEECSTBS--TTEEEEEETTTTBCT-EEEE CS
        CHAP   9 qCvefaywrlrqag..........gnaddWnnakkakg.........yknqanvgsstpkvGdivvfdrggeggyGHVai 69 
                  C+ + +  +++a           g+a+         +         y+    + s + ++Gd+ +f++ ++ + GH  +
  EFC36249.1 217 KCAKYTANAIEKALtgktytinrpGSAK---------DfgswlqkmgYQ----KVSGPMQPGDVQIFQAIPGHPDGHMQM 283
                 6999998887766553334444443344.........333433233366....5555779*******9988767999766 PP

>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5  32.2   0.00045         2     169     342 ..      43     224 ..       9     273 .. 0.46

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00045
        SOG2 169 kkragrtksksisttssgssstlvssaesstesrassvtytartRhagsfsaqdveqGaaltplrsd.qipfnl........srsrrssssgnsaspaa 258
                   r ++++s+s   tss+s ++++ss + +  +++  +++  ++R+++  +  + + ++  +p +s+ +  +++         ++ r++s++n+ +p++
  EFC36249.1  43 R-RSSSSSSSSRRPTSSSSYRRPTSSYNRRPTTSNNRRPTSYNRRPTTTTNNRRRPTSNTRRPTSSNnR-RQPTnrrptrptRTNVRNGSNNNRRKPSN 139
                 2.2222222233333333333333333333333332333222335555555444444444444333321.11122345555567777777777777777 PP

        SOG2 259 ngaqsetsersasssgvqssasstPlgegstspp..galsrqslsttgststltsssksrs......ssrsntnasastprslattpappas 342
                 +++  ++++r ++     ++ +s+P+g++++s+    +++rq ++t  ++++ ++  +s+       +s++++  sas ++s+ + ++ +a+
  EFC36249.1 140 SVRPGMSNQRFSQ----YRNTQSKPYGANTQSNQpaRQPTRQ-PTT--AQQPAQQNIRSTApssqvvQSAMSNVRSASHSQSQGKCAKYTAN 224
                 7775554443333....2334444555555554111222222.212..22222211121112223443333333344444444444443333 PP

>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0  18.8    0.0011       5.1      80     246 ..      69     217 ..      18     267 .. 0.39

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0011
       TFIIA  80 sqapastsqslpslvipagksvqslta....nssaataatfslpakleppvqipagvtlqtasgqlykvnvqasgaqqiaaqplqqvvqqsqgsaaqss 174
                 ++                             n+++ t+ +  +  +++ +   p++ t +++s     +n   + ++++ ++p  ++v ++++++  + 
  EFC36249.1  69 NR------------------------RpttsNNRRPTSYNRRPT-TTTNNRRRPTSNTRRPTS-----SNNRRQPTNRRPTRPTRTNVRNGSNNNRRKP 137
                 11........................111112221222222221.222223333333322222.....2235555555666666666665444444444 PP

       TFIIA 175 vaalqaq.sqqaqalaepqqqlekqqqqqqqqqqqqqqqqvqqqqqe......esqqaqqasqeqvag.sqvessqtdga 246
                  +++ ++ s+q  ++ ++ q +  ++++q +q+++q  +q ++ qq       + +  +q  q+++++ ++++ sq +g+
  EFC36249.1 138 SNSVRPGmSNQRFSQYRNTQSKPYGANTQSNQPARQPTRQPTTAQQPaqqnirSTAPSSQVVQSAMSNvRSASHSQSQGK 217
                 44444443222222222222211122222222222222211111110000111111111111111111111112222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1435  (0.0800379); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.86u 0.32s 00:00:01.18 Elapsed: 00:00:00.47
# Mc/sec: 2054.39
//
Query:       EFC36250.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.022   14.2   0.2      0.034   13.6   0.2    1.2  1  Rax2      Cortical protein marker for cell polarity
          1    9.8  15.5      0.068   13.6  10.5    1.5  2  EGF_2     EGF-like domain
        5.8    7.3  11.0         12    6.3  11.0    1.6  1  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> Rax2  Cortical protein marker for cell polarity
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.2   5.8e-06     0.034     115     212 ..     160     268 ..     139     268 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 5.8e-06
        Rax2 115 yngtswiPYlltsssnnekgsissifleksnsfssssdlk..................................kkkkklsrgfVVlIgLAlALgtval 179
                 y+g +   ++ ts+++                       +                                  + k +l+ g+V   g  l+L +v+l
  EFC36250.1 160 YTGYKTFQFYNTSHDS-----------------------RkiidaqdvqiirnefqtiaiviynaadlpvefnvTLKANLASGKVQTAGIFLSLSVVML 235
                 3333333333333333.......................144444444444444445556667888888888889999********************* PP

        Rax2 180 lgllgiilayirkkregyepakpridenemldr 212
                 +++++ ++ +i+++++  + + p+ +e ++++r
  EFC36250.1 236 MVIVFEVVLLIQRSNNRKQFILPKLQERQDIQR 268
                 *****************9999999999999986 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.2         2   1.2e+04      18      25 ..      10      21 ..       9      23 .. 0.48
   2 ?   13.6  10.5   1.1e-05     0.068       1      32 []      25      53 ..      25      53 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2
       EGF_2 18 cG....qCdCds 25
                cG    +C+ ds
  EFC36250.1 10 CGdatkKCHSDS 21
                444443576555 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 1.1e-05
       EGF_2  1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                C++    C+  GtC+ +  +CdC++gy+ ++C
  EFC36250.1 25 CPS---LCSKKGTCNLEKKKCDCQPGYYDNNC 53
                764...5*******733337********9999 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  11.0    0.0021        12       3      31 ..      24      51 ..      16      56 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0021
                STT..STTT-EE.EEETTTEEEEEECTTEEST CS
         EGF  3 pnp..CsngGtC.vdtgrggytCiCpeGytGk 31
                p+p  Cs+ GtC ++ +    +C+C++Gy  +
  EFC36250.1 24 PCPslCSKKGTCnLEKK----KCDCQPGYYDN 51
                45699*******77777....*******9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       920  (0.0513135); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.25s 00:00:00.80 Elapsed: 00:00:00.45
# Mc/sec: 1960.25
//
Query:       EFC36251.1  [L=408]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.099   12.9   0.8       0.38   11.0   0.1    2.2  2  DUF3006   Protein of unknown function (DUF3006)
       0.64   10.1   4.7       0.86    9.7   0.0    3.5  4  DUF1447   Protein of unknown function (DUF1447)


Domain annotation for each model (and alignments):
>> DUF3006  Protein of unknown function (DUF3006)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.32   2.8e+03      49      61 ..      41      53 ..      39      55 .. 0.89
   2 ?   11.0   0.1   4.2e-05      0.38       5      53 ..     294     348 ..     292     354 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.32
     DUF3006 49 peetekrkeriqe 61
                +eet+ ++++i++
  EFC36251.1 41 EEETKHAENQIKD 53
                69*******9997 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 4.2e-05
     DUF3006   5 RfEgdlAVleledget.idiprsdLpegakeGdvLeie..dde...ieldpeete 53 
                 +fE+ ++ +e+++g++ i i ++++ + ++   vL++   +d+   ie + e t+
  EFC36251.1 294 KFEEPYVYVEFNEGRMvIPIMVERFDQQVHVDFVLDLIdaNDGnvcIETNMECTQ 348
                 69***********999677******************965442566666666665 PP

>> DUF1447  Protein of unknown function (DUF1447)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.34   3.1e+03      23      50 ..     186     211 ..     178     213 .. 0.73
   2 ?    9.7   0.0   9.6e-05      0.86      37      67 ..     236     266 ..     232     267 .. 0.89
   3 ?   -0.9   0.2      0.19   1.7e+03      21      50 ..     299     330 ..     278     334 .. 0.58
   4 ?   -1.9   0.0       0.4   3.5e+03      31      50 ..     366     387 ..     353     396 .. 0.56

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.34
     DUF1447  23 YleaeseeevrklveenteyniEfieel 50 
                 Y+  +s  +v +  ++n  y+ E i+ l
  EFC36251.1 186 YITNDSCGQVYESFRNN--YKTENIQFL 211
                 77778888888888777..766666655 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 9.6e-05
     DUF1447  37 eenteyniEfieelsgkaLeYEkesedfklt 67 
                  +++++niE  ++++g+aL++   +e+f lt
  EFC36251.1 236 GDEKDFNIELCRSIQGNALQFALVDESFDLT 266
                 57789*****************999999987 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.19
     DUF1447  21 sLYleaeseeevrklveen..teyniEfieel 50 
                  +Y+e ++ + v   + e+  ++ +++f+  l
  EFC36251.1 299 YVYVEFNEGRMVIPIMVERfdQQVHVDFVLDL 330
                 45777777777666555554566777777665 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 0.4
     DUF1447  31 evrklveen..teyniEfieel 50 
                 e  + +ee    + n+ fi++ 
  EFC36251.1 366 ETASVIEEDslFHENVKFIQST 387
                 4444444442233467777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (408 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1967  (0.109711); expected 358.6 (0.02)
Passed bias filter:                      579  (0.032294); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 2597.25
//
Query:       EFC36252.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      0.007   16.1   0.5        2.9    7.6   0.1    2.2  2  Claudin_2        PMP-22/EMP/MP20/Claudin tight junction
  ------ inclusion threshold ------
       0.67    8.6   2.5        1.1    8.0   2.5    1.4  1  DUF2207          Predicted membrane protein (DUF2207)
        5.2    7.1   6.6         18    5.3   1.9    2.3  2  MRAP             Melanocortin-2 receptor accessory protein fa
        6.9    6.8   9.9        5.9    7.0   5.3    2.0  2  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe


Domain annotation for each model (and alignments):
>> Claudin_2  PMP-22/EMP/MP20/Claudin tight junction
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.1   0.00064       2.9      77     121 ..       9      53 ..       2      61 .. 0.80
   2 !    6.9   0.0    0.0011       4.7     120     147 ..     129     156 ..     102     170 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00064
   Claudin_2  77 ivsisatsllalarfvqvlliLslvlivlavvlgllallkqsvll 121
                 + +    ++l+ ++++++l++Lsl l+v +v+ +++ l ++++++
  EFC36252.1   9 YPNAPQRLALSSFIMFMFLFLLSLCLVVPGVISLTSQLKCERKIV 53 
                 555566778888999999**************9999888877655 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0011
   Claudin_2 120 lllkaagilfllagvlgllavvvfiesv 147
                 +l+ aagi+++++  ++l+++ vfi+  
  EFC36252.1 129 GLFAAAGICLIISFGFLLISLTVFIIGL 156
                 7899999999999999999999998755 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   2.5   0.00024       1.1     391     442 ..      21     177 ..       5     185 .. 0.65

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00024
     DUF2207 391 iilglilillallllvll................................................................................. 408
                 +i++++l+ll+l+l+v++                                                                                 
  EFC36252.1  21 FIMFMFLFLLSLCLVVPGvisltsqlkcerkivsvdrltlndtipnrikyrytlelsikdnsirynsisiyecfegeceinkfenfttfctydprkkgp 119
                 444444444444444444555666677777777777777777777777777777777777777777777777777777777777777777777777777 PP

     DUF2207 409 ........................lvfllilllillliaiivlllfsrllgrrteeGa 442
                                         + +++++++i++l++i+ ll+ + ++++r  eG+
  EFC36252.1 120 rldtqadfiglfaaagicliisfgFLLISLTVFIIGLQFIFELLYRKDCFKARIMEGN 177
                 7777777666666655555554447777777788888888888887778887766665 PP

>> MRAP  Melanocortin-2 receptor accessory protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   1.9    0.0041        18      45      60 ..      17      32 ..      15      45 .. 0.88
   2 ?    4.1   0.2    0.0098        44      42      64 ..     145     167 ..     123     196 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0041
        MRAP 45 sLavfvvllflvLlyl 60
                +L++f++++fl Ll l
  EFC36252.1 17 ALSSFIMFMFLFLLSL 32
                799********99976 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.0098
        MRAP  42 fWvsLavfvvllflvLlylsksG 64 
                 + +sL vf++ l +++ +l +  
  EFC36252.1 145 LLISLTVFIIGLQFIFELLYRKD 167
                 358*******9999988776655 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.1     0.044     2e+02      68      87 ..      19      38 ..      12      58 .. 0.52
   2 ?    7.0   5.3    0.0013       5.9      37      62 ..     128     154 ..     124     164 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.044
  Phage_holin_3_6 68 aalivaavllvlagvlalvg 87
                     + +i++ +l++l + l++ g
       EFC36252.1 19 SSFIMFMFLFLLSLCLVVPG 38
                     33333333333333333333 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0013
  Phage_holin_3_6  37 agllgaagvlallalllllval.alal 62 
                      +gl++aag+++++++++ll+ l ++++
       EFC36252.1 128 IGLFAAAGICLIISFGFLLISLtVFII 154
                      69********************64444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       874  (0.0487478); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1355.78
//
Query:       EFC36253.1  [L=629]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-77  260.8   0.1    4.9e-77  259.0   0.1    1.9  1  MCD           Malonyl-CoA decarboxylase C-terminal domain
    3.3e-06   27.1   0.7    4.2e-05   23.6   0.2    2.9  2  MCD_N         Malonyl-CoA decarboxylase N-terminal domain
     0.0035   17.2   2.7     0.0061   16.4   2.7    1.3  1  DUF4652       Domain of unknown function (DUF4652)
     0.0082   16.7   2.4        3.1    8.4   0.0    2.8  2  SIX1_SD       Transcriptional regulator, SIX1, N-terminal SD 
  ------ inclusion threshold ------
      0.081   13.1   0.7         11    6.3   0.1    2.5  2  DUF3993       Protein of unknown function (DUF3993)
        0.2   11.6   1.3       0.28   11.2   0.0    1.8  2  DUF441        Protein of unknown function (DUF441)
        1.8    9.0   5.2        5.3    7.5   1.2    3.1  3  FRB_dom       FKBP12-rapamycin binding domain
        7.8    5.8   7.2        5.4    6.3   2.0    2.2  2  SF-assemblin  SF-assemblin/beta giardin


Domain annotation for each model (and alignments):
>> MCD  Malonyl-CoA decarboxylase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  259.0   0.1   2.2e-80   4.9e-77       1     256 [.     300     597 ..     300     598 .. 0.84

  Alignments for each domain:
  == domain 1  score: 259.0 bits;  conditional E-value: 2.2e-80
                 GG-EEEEESTT.SBHHHHHHHHHH--TT--SSHHHHHHCC..STTEEEEEEEBTTCTTSESEEEEEEEESS--S-CHHHHSTTS----GGG-SEEEEEE CS
         MCD   1 gfLelrritwe.spaslleklikyEavHeirdwedlkrRl..dsdRrcfaffHpalpdePlifvevAlvkeiaksiqelldeeaeaedaekattAifys 96 
                 +fLe ++++w+ ++a+l+ek+i+yE vH+i+++e lk+Rl  +++R++++ fH a+p+ Pl++++vAl+++ia++++++ d e+++  + +++tAifys
  EFC36253.1 300 SFLECKELDWReTNAQLVEKIIHYERVHPIANMEALKNRLapTPNRKMYGLFHAAMPRVPLVVLQVALMDSIASNMRQVHDIEKAK-ATPNVNTAIFYS 397
                 59********6599**************************87789**********************************9988866.56789******* PP

                 EEE--CCCTTS--HCHHHHHHHHHHHHH-.......TT--EEEEEE--TTSHHHHHHH.........CCGCC-TT--HHHHCCHGGC............ CS
         MCD  97 isntqkGLrgislGnfLiKrvveelkrel.......pklktfatLsPiPgfrkwlkre.........lkkesealleeeeaealael............ 167
                 is+tq+GL+gi+lGn+LiK+vv  l+++         ++ +f+tLsPiP+f+kwl+++         +k ++e+ll++++ e l++l            
  EFC36253.1 398 ISSTQAGLTGIELGNYLIKKVVGILQQKQlvsdnygGDIVQFSTLSPIPSFMKWLSQKlriecssdlNKFHDESLLRSADVELLKKLameepqlfglts 496
                 **********************988775422222224799*****************976666655444566677777777777777************ PP

                 ..................T......SSTCTSSCHHHHHHHHHHHHHHHHHHHT-B-TTSBSSCCHHHHHCTT-EEEEEETTS--SHHHHHHHTT-EEEE CS
         MCD 168 ......eaeaakllkklle......eeewaedeelaeklkevllrlaarYllkekrkkraldpvarFHlgnGArlerlnwladtsekglkqslglmvnY 254
                       + +a++ll +l++       ++++++ + +eklk ++ rl+arYl+kek+k++aldpv +FHl+nGA ler+nw++d+s + lk+s+g+mvnY
  EFC36253.1 497 pkectsDLQAKELLLSLVDgivgggINSTTDSLHPSEKLKPLMERLCARYLYKEKHKGKALDPVGNFHLRNGACLERINWKGDLSVRRLKESYGMMVNY 595
                 *999883334444333333111111345555556699************************************************************** PP

                 EE CS
         MCD 255 lY 256
                 +Y
  EFC36253.1 596 KY 597
                 *9 PP

>> MCD_N  Malonyl-CoA decarboxylase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.6   8.1e+03      64      83 ..      41      60 ..      12      62 .. 0.67
   2 !   23.6   0.2   1.9e-08   4.2e-05      22      85 .]     197     297 ..     177     297 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.6
                TTT-GCHHHHHHHHHHHHHH CS
       MCD_N 64 lkkekelraldadlehllss 83
                + ++ + ++l+++++h +++
  EFC36253.1 41 KTTNIHCTSLQRNFHHDFAL 60
                33344777888888887776 PP

  == domain 2  score: 23.6 bits;  conditional E-value: 1.9e-08
                 H.......HHHHHHHHHCSBHHHHHHHHHTTS............TTHHHHHHHHHHHHHHHTTT-G..................CHHHHHHHHHHHHHH CS
       MCD_N  22 e.......kaeeeLrealeprrqeLlrrlnla............pgGvkfLVdmRadllallkkek..................elraldadlehllss 83 
                 e       +++++Lr++lep + ++l ++ l+             +G++f+ +mR+dll+ +++ +                   l++l+++l +llss
  EFC36253.1 197 ErnilgylNTIQQLRTSLEPYYEKFLEQFILIlmkkeisigsqsMNGLEFVMQMRKDLLDIIATLQkqqstpatsdykkfilpiLLSDLNTNLVRLLSS 295
                 3456666678899999999999999999965422222222222279**************999998999****************************** PP

                 HT CS
       MCD_N  84 WF 85 
                 WF
  EFC36253.1 296 WF 297
                 *9 PP

>> DUF4652  Domain of unknown function (DUF4652)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   2.7   2.7e-06    0.0061      36     175 ..      59     201 ..      27     208 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.7e-06
                 -EE-.EEEEE--SS---SSB---EE-TTSSEEEEEESSTTTT-SSS--EEEEEETTTTEEEEEEE--S.SS-EEEEEEEESSSSE...EEEEEEESSSS CS
     DUF4652  36 sekinfikkeleensektfnteWkesenkkysaiieGkGsealeeGiGkiiikelkeqklysleiden.ktkksPkyleWiddkn...llvvigsshGt 130
                 + + n  k +le++  ++f+t++k+  +  ys i   kG+ +lee i  ++    + +++ ++ei e+  +k +  y++ +d +    ++ v+   +G 
  EFC36253.1  59 ALQFNETKCNLEKQEATSFSTNFKQYWESIYSYI--QKGDVSLEESIKGVV-HGININNINKVEIPEDiSQKLAQMYMKNLDKNGkirFFEVMIMHFGG 154
                 4556678999**********************98..5999*******7665.55999999999*976527788999****9988533356677778888 PP

                 S-S-BEEEEE..ETTT-EEEEEE--S-TTEEEEEEEEETTEEEEEEE CS
     DUF4652 131 vskGGdlyml..nvetgevtllikakdkkkqvvsaekkgdkinlkvn 175
                 v     l m+  nv t++ ++l+++ dk k  ++ +++ ++++ +++
  EFC36253.1 155 VPIAPLLQMMsnNVVTDNSNTLLQTLDKMKGALQNVQSSENVERNIL 201
                 8888877776659***************9999999999888877665 PP

>> SIX1_SD  Transcriptional regulator, SIX1, N-terminal SD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   1.4    0.0068        15      19      84 ..       5      67 ..       1      78 [. 0.84
   2 !    8.4   0.0    0.0014       3.1      81     105 ..     543     567 ..     527     571 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0068
     SIX1_SD 19 ierLarfleslpkseelkksesvlkaralvafhsgefkelykllesrkFskksheelqelwleahY 84
                 +rL+ ++++l+++   ++s+s++ a+  v+ h+++f++  + +++++ ++++h++    ++e+++
  EFC36253.1  5 HRRLSVLINHLKQT---TTSNSLVAAHHRVVSHQNSFTTKTTNIHCTSLQRNFHHDFALQFNETKC 67
                67899999999995...4699*************************99999999998888877776 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0014
     SIX1_SD  81 eahYkeaekkrgreLgavekYrlRk 105
                  a+Y  +ek++g+ L +v  ++lR 
  EFC36253.1 543 CARYLYKEKHKGKALDPVGNFHLRN 567
                 599********************96 PP

>> DUF3993  Protein of unknown function (DUF3993)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.1    0.0047        11      55     109 ..      47     101 ..      16     108 .. 0.83
   2 ?    4.6   0.1     0.016        36      28      69 ..     184     224 ..     157     237 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0047
     DUF3993  55 ievLePYftdafasvfveenaseekagniiyGtdageyliPffsfteetkvaied 109
                    L+  f + fa  f e     ek+    + t++ +y   ++s+ +   v+ e+
  EFC36253.1  47 CTSLQRNFHHDFALQFNETKCNLEKQEATSFSTNFKQYWESIYSYIQKGDVSLEE 101
                 4568889**************************************9999998865 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.016
     DUF3993  28 kevletlqsayeaqfslsekersleemievLePYftdafasv 69 
                 k  l+ +qs+ +++ ++ +   +++++   LePY+++ f++ 
  EFC36253.1 184 KGALQNVQSSENVERNILGYLNTIQQLRTSLEPYYEK-FLEQ 224
                 5678999***************************985.4444 PP

>> DUF441  Protein of unknown function (DUF441)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.2       2.6   5.9e+03     118     130 ..     149     161 ..     147     163 .. 0.84
   2 ?   11.2   0.0   0.00013      0.28      39      99 ..     350     410 ..     337     422 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.6
      DUF441 118 vvflkGvpvGPli 130
                 ++ ++Gvp+ Pl+
  EFC36253.1 149 IMHFGGVPIAPLL 161
                 6789*******96 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00013
      DUF441  39 llekkglelGviiltiavLvPiatgkislkellealkslkgliallvgilvavlsgkGvel 99 
                 l++  + ++ +++l +a++  ia++  +++++ +a ++++  +a++ +i  +  + +G+el
  EFC36253.1 350 LFHAAMPRVPLVVLQVALMDSIASNMRQVHDIEKAKATPNVNTAIFYSISSTQAGLTGIEL 410
                 55566667889***********************************************997 PP

>> FRB_dom  FKBP12-rapamycin binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   1.2    0.0024       5.3      43      93 ..      41      91 ..       8      95 .. 0.78
   2 ?   -0.4   0.0      0.71   1.6e+03      29      74 ..     172     217 ..     160     229 .. 0.64
   3 ?    1.3   0.1       0.2   4.5e+02      41      83 ..     231     273 ..     180     277 .. 0.69

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0024
     FRB_dom 43 llekgpetlreasFaqafgreLkeaeewlkkykkteneedlnqawdiyyev 93
                ++++ + t  +++F++ f  + +e +  l+k + t+  ++++q w+  y+ 
  EFC36253.1 41 KTTNIHCTSLQRNFHHDFALQFNETKCNLEKQEATSFSTNFKQYWESIYSY 91
                33344459999**********************************987765 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.71
     FRB_dom  29 nveamlklleplhellekgpetlreasFaqafgreLkeaeewlkky 74 
                 n + +l++l++++  l++ +++ + +  +  + + +++ ++ l+ y
  EFC36253.1 172 NSNTLLQTLDKMKGALQNVQSSENVERNILGYLNTIQQLRTSLEPY 217
                 5566677777777777765555555555556666666666666655 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.2
     FRB_dom  41 hellekgpetlreasFaqafgreLkeaeewlkkykkteneedl 83 
                 +++++ g ++++  +F+ + +++L +  ++l+k ++t  ++d 
  EFC36253.1 231 KKEISIGSQSMNGLEFVMQMRKDLLDIIATLQKQQSTPATSDY 273
                 3444446678888888888888888888888777776666555 PP

>> SF-assemblin  SF-assemblin/beta giardin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   2.0    0.0024       5.4      65     163 ..      35     136 ..      12     148 .. 0.84
   2 ?    1.9   0.2     0.053   1.2e+02      75     126 ..     161     214 ..     157     220 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0024
  SF-assemblin  65 qeefkkeikklqek..ikeevddlalelkkaveeln.ekinnveanvenekakrrdaieklakelvkelneleaaideEkaerkkkedqlnkkveEd 158
                   q+ f  +  +++ +  +++  +d al+++++  +l+ ++ +  ++n ++  ++  + i+k   +l +++  ++ +i+ +++++++  + + +k++  
    EFC36253.1  35 QNSFTTKTTNIHCTslQRNFHHDFALQFNETKCNLEkQEATSFSTNFKQYWESIYSYIQKGDVSLEESIKGVVHGININNINKVEIPEDISQKLAQM 131
                   67777777777766224556789999999988888636799*******************************************************9 PP

  SF-assemblin 159 lkkls 163
                    +k+ 
    EFC36253.1 132 YMKNL 136
                   99974 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.053
  SF-assemblin  75 lqekikeevddlalelkkaveelnekinnvea..nvenekakrrdaieklakel 126
                   lq   +++v+d    l ++++++   ++nv++  nve ++    + i++l+++l
    EFC36253.1 161 LQMMSNNVVTDNSNTLLQTLDKMKGALQNVQSseNVERNILGYLNTIQQLRTSL 214
                   67778999**********************875578888888888999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (629 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1003  (0.0559429); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.47
# Mc/sec: 3995.54
//
Query:       EFC36254.1  [L=362]
Description: alternative oxidase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.4e-51  173.0   1.0    9.1e-51  172.5   1.0    1.2  1  AOX       Alternative oxidase
  ------ inclusion threshold ------
      0.097   13.0   0.8          5    7.5   0.0    2.9  3  YrzK      Uncharacterized YrzK-like


Domain annotation for each model (and alignments):
>> AOX  Alternative oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  172.5   1.0     1e-54   9.1e-51      15     215 .]     153     349 ..     141     349 .. 0.86

  Alignments for each domain:
  == domain 1  score: 172.5 bits;  conditional E-value: 1e-54
         AOX  15 epktlsDkvaiglv.kllRwlaDlvtrekkleltekkylhRaifLetvAgvpgmvaavlrhLrslrlm.....krdkgwirtlleeaenermHllvllk 107
                 ep++ +D+ a  +  +++  ++ ++++         ++l+  +fLet+ + pgmv+++ rh+ slr +     k+++  +  lleeaen+rmH+lvll+
  EFC36254.1 153 EPRNRTDRWAQWWArRCVARILKFLFGR--------NMLRYSVFLETMSATPGMVGGMWRHFASLRSKpidrcKKEHLRVGALLEEAENHRMHMLVLLE 243
                 5666666665444312334444555555........89999************************97533322677777899***************** PP

         AOX 108 laeptlleRllvllaqgvffniflllYllsPrv.ahrlvgyleEeavvtYtqliedideGkleewekvkaPeiAlqYwklqeeatlrdvilliRaDEak 205
                 +++ ++leR+l+++aq  f + ++ +Y l+ ++  hr+vgyl+E av +Y  ++++ide k+    + +aPe+A++Yw+l+++atlrdvil+iR DE k
  EFC36254.1 244 MTHQNILERILMVVAQLSFSQYYFYIYSLAGKTfSHRFVGYLAETAVESYGLVLKQIDEKKIA---NPPAPEMAINYWNLPKNATLRDVILAIRMDECK 339
                 ****************************9998548**************************99...5******************************** PP

         AOX 206 hrdvnhtlan 215
                 hr+ nh+l++
  EFC36254.1 340 HREFNHALSD 349
                 ******9975 PP

>> YrzK  Uncharacterized YrzK-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.68   6.1e+03      38      52 ..     112     126 ..     111     128 .. 0.83
   2 ?    2.5   0.2      0.02   1.8e+02      20      34 ..     135     149 ..     125     153 .. 0.85
   3 ?    7.5   0.0   0.00056         5      30      50 ..     283     304 ..     280     307 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.68
        YrzK  38 EyGltSKEelekKkn 52 
                 E Gl  K  + +Kk 
  EFC36254.1 112 EEGLEVKNTIIRKKE 126
                 569999999999996 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.02
        YrzK  20 lkeHadpdraGfleE 34 
                   +H + +  Gfl+E
  EFC36254.1 135 WMDHGESEMFGFLNE 149
                 579**********99 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.00056
        YrzK  30 GfleETAsE.yGltSKEelekK 50 
                 G+l ETA E yGl+ K   ekK
  EFC36254.1 283 GYLAETAVEsYGLVLKQIDEKK 304
                 9******9989**999755555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 2003.61
//
Query:       EFC36255.1  [L=511]
Description: citrate synthase family member [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   1.3e-136  455.4   0.0   1.6e-136  455.1   0.0    1.1  1  Citrate_synt  Citrate synthase, C-terminal domain


Domain annotation for each model (and alignments):
>> Citrate_synt  Citrate synthase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  455.1   0.0  9.1e-141  1.6e-136       2     361 .]      78     446 ..      77     446 .. 0.97

  Alignments for each domain:
  == domain 1  score: 455.1 bits;  conditional E-value: 9.1e-141
                   GTTEEEEEESSEEEETTTTEEEETTEEHHHHHHHHS-HHHHHHHHHHSS---HHHHHHHHHHHHCTTS--HHHHHHHHCSSTTS-HHHHHHHHHHHH CS
  Citrate_synt   2 lrgvaaleteisevdgekgelrYRGydieeLaeekssfeevaylLltgelPtkeelkefkeelaearklpekvlealealpkdahpmavlraavsal 98 
                   ++++a+++++i+++dge+gelrYRGy+ieeLa ekssf evaylL++gelPt++++++++++++ +++++e+++++l++++ dahpm +l++a+sal
    EFC36255.1  78 FMNTAVADSKICYIDGEAGELRYRGYKIEELA-EKSSFLEVAYLLIYGELPTQSQYNDWCQKITTHTFIHENLVSMLKTFRYDAHPMGILISATSAL 173
                   6899****************************.8*************************************************************** PP

                   HHHSTT..........CTCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS.--.---TTSSHHHHHHHHHHS.....S---HHHHHHHHHHHHHH CS
  Citrate_synt  99 saddee..........seakeeseeaalrdalkliAklptiaaaiyrarlgrepl.epddklsyaenflymlrg.....kkpdeeeaklldlalvlh 179
                   +++++e          ++++++++++++r    l++k+ptiaa +yr+r gr p+  p ++lsy+enflyml++     ++p++++ak+ld++++lh
    EFC36255.1 174 GTFYSEanpalvgtdvYKDENKRNKQIFR----LLGKVPTIAACAYRHRIGR-PYnTPVNHLSYTENFLYMLDRlsepnYRPHPRLAKALDVMFILH 265
                   *************9988888889999999....******************7.88568899***********9788999****************** PP

                   S--SSSHHHHHHHHHHTTT--HHHHHHHHHHHHTSTTTTTHHHHHHHHHHHHSSGG.GHHHHHHHHHHTTTS--TTBC-SSSSS--HHHHHHHHHHH CS
  Citrate_synt 180 aDHelnaSTfaarvvaStladlysaiaagigalkGplhgganeavlkmleeigsaeveveeylekvlakekerlpGfGHrvykksDpRakilkelae 276
                   aDHeln+ST+a+r+v+S+l+d+y+a++++ +al+Gplhgganeavl+ml+ei ++e +v+++l++v+ak k++l+GfGHrvyk++DpRakilk +a+
    EFC36255.1 266 ADHELNCSTAAMRHVGSSLVDPYTAVSSSASALYGPLHGGANEAVLHMLDEIAKPE-NVPQFLQDVKAK-KRKLMGFGHRVYKNYDPRAKILKGVAK 360
                   ****************************************************9999.***********8.6************************** PP

                   HHHTCHTHHHHHHHHHHHHHHHHHHHHCHHGCT-EB-THHHHHHHHHHTT--GGGHHHHHHHHHHHHHHHHHHHHH..HT------E CS
  Citrate_synt 277 elaeekgkdpllklaeeleevapevlkekeeknlypNvDfysgvlyralgipeelftvlfaisRvaGwlAhileql..adnkiiRPr 361
                   e+++  gk++l  +aeele  a ++ ++++ + l+pN+Dfysg++y++lg+p+++f+vlf i RvaGwlAh++e     + ki+RPr
    EFC36255.1 361 EVFDICGKSKLWSIAEELESQALKDDYFVS-RRLFPNIDFYSGLIYSSLGFPTDMFPVLFTIPRVAGWLAHWREMVmdPNLKIFRPR 446
                   ******************************.*******************************************84467799****8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (511 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       627  (0.0349713); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 2856.78
//
Query:       EFC36256.1  [L=731]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-64  218.3   4.6      5e-63  213.0   5.9    2.1  2  ABC_membrane_2  ABC transporter transmembrane region 2
    4.2e-20   72.7   0.0      1e-19   71.4   0.0    1.7  1  ABC_tran        ABC transporter
     0.0011   18.5   0.0     0.0027   17.3   0.0    1.6  1  AAA_7           P-loop containing dynein motor region
     0.0035   17.9   5.3      0.039   14.5   0.2    2.8  3  AAA_23          AAA domain
  ------ inclusion threshold ------
      0.015   15.1   1.1       0.06   13.2   0.1    2.4  3  AAA_21          AAA domain, putative AbiEii toxin, Type IV TA
      0.015   15.2   0.0      0.029   14.3   0.0    1.4  1  RsgA_GTPase     RsgA GTPase
      0.025   14.3   0.0      0.058   13.1   0.0    1.5  1  AAA_29          P-loop containing region of AAA domain
      0.076   12.3   0.1       0.63    9.3   0.0    2.3  3  Zeta_toxin      Zeta toxin
       0.11   12.1   0.0       0.21   11.2   0.0    1.4  1  AAA_27          AAA domain
       0.12   11.7   0.1       0.23   10.8   0.1    1.3  1  FtsK_SpoIIIE    FtsK/SpoIIIE family
       0.16   11.5   0.0        0.3   10.6   0.0    1.4  1  UDPG_MGDP_dh_N  UDP-glucose/GDP-mannose dehydrogenase family,


Domain annotation for each model (and alignments):
>> ABC_membrane_2  ABC transporter transmembrane region 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  213.0   5.9   3.1e-66     5e-63      13     269 .]     146     402 ..     140     402 .. 0.98
   2 ?    1.4   0.0      0.11   1.7e+02      41      81 ..     649     689 ..     644     694 .. 0.92

  Alignments for each domain:
  == domain 1  score: 213.0 bits;  conditional E-value: 3.1e-66
  ABC_membrane_2  13 eallllvlllllvlrtllsvlvaqldgklvkalvaknvraFvlsllkfallavpasfvnsalkYltqkLalafRkrLtkhllseYlknrtyYkvs 107
                       +l+++++ l+vl+ ++  + + ++g+++++l+ k+ + F  s +kf+  +++ s++  +l+Yl + +al+fRk+Lt  l+++Y+++  yYk++
      EFC36256.1 146 FIGLIVMVSSLVVLKSVVICRSNFISGDMMEYLLSKKRDLFFESFVKFLFSIILQSLLSPTLNYLIELMALHFRKNLTMNLHEKYFSDLCYYKIN 240
                     568999999************************************************************************************** PP

  ABC_membrane_2 108 nlderidnpDqritqDvekFtsslssLlsglvkpildvilftfiLwslsgtlgllllllyvllatvilriigpplgklvaeeeklegefRylhsr 202
                     nld r+  +DqritqD+e+ ++ +s+L+++++ p +d++l+t  L++l+g+ g +++ +y+++a  il +++p+++k +a+ +++eg+fR+lh r
      EFC36256.1 241 NLDRRLGAVDQRITQDIEILSMRISELFTDILHPSVDLVLYTNELVRLMGWSGFVSVSVYFFIAVGILSRVSPNFTKFSAQVQNMEGNFRQLHNR 335
                     *********************************************************************************************** PP

  ABC_membrane_2 203 litnaEeIAFyrGeevEkkqlqrrfkslidnlrrilsrrlrlgiieafvlkYlasilgyvlvalpif 269
                        n+E+I Fy+G e E+k+++  f++l+d ++ ++++ ++++++++f++kY+  +++  ++ lp+f
      EFC36256.1 336 CSINSEQISFYSGDETERKKVEDYFDKLTDYSNFVIKKNFSFSMVNDFLTKYFPHTYSSFIIGLPAF 402
                     *********************************************************9999999987 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.11
  ABC_membrane_2  41 lvkalvaknvraFvlsllkfallavpasfvnsalkYltqkL 81 
                      ++++ a ++++ ++++ k+ + ++ +s + ++ kY++q+L
      EFC36256.1 649 CTSCITADDEEKLYKKCTKMEITCITISHRPALEKYHKQRL 689
                     6789999********************************99 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.4   0.0   6.3e-23     1e-19       2     137 .]     503     651 ..     502     651 .. 0.80

  Alignments for each domain:
  == domain 1  score: 71.4 bits;  conditional E-value: 6.3e-23
                 EEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGG..B-HHHCCHCEEEE-SS.--S-TTSBHHHH...........HHHTCHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxx.xxxxxxxxxxxx...........xxxxxxx RF
    ABC_tran   2 knvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlke..qeleslrkeigvlpqe.pqlfpeltvren...........esdeeie 86 
                 kn+++++++ e ++i G+nGaGKS+L+++l  l    eG+i    ++ +   ++ + l+kei +lpq+  +l   l  r +           + d  ie
  EFC36256.1 503 KNLTFHVNKKEHIVISGSNGAGKSSLFRVLGSLWPLHEGSI----HKPQAcgNNSSGLHKEIFYLPQKpYNLVGSL--RGQiiypekeykddWNDGMIE 595
                 89***************************************....23333346899************54444444..4445777777554444444** PP

                 HHHHHSTTGGTTCBGESTTS......GGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  87 kalsklglkelkdtvvkssp......ssLSgGqkqrvalarallkkpkllllDEpta 137
                 ++l+ +g+++l  +  +         +sLS G++q++al+r++  kpk  +lDE+t+
  EFC36256.1 596 ELLHDFGISYLVSRSEHG-FetvqdwNSLSRGEQQKLALVRLFYHKPKYAILDECTS 651
                 *********955544322.2345567*****************************96 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   1.6e-06    0.0027       5      51 ..     484     530 ..     481     537 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.6e-06
       AAA_7   5 eeakfseilVptvdtvrysyllelllknkkpvllvGptGtGKtviik 51 
                 +e+kf++++++t d + +   l+ ++++k ++++ G+ G GK+++ +
  EFC36256.1 484 DEIKFTNVTIKTPDEITLAKNLTFHVNKKEHIVISGSNGAGKSSLFR 530
                 5799***************************************9875 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       6.1   9.9e+03      75     103 ..      79     105 ..      46     118 .. 0.56
   2 ?    5.0   0.2     0.019        31     112     160 ..     320     368 ..     308     374 .. 0.86
   3 !   14.5   0.2   2.4e-05     0.039      13      38 ..     505     531 ..     452     534 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 6.1
      AAA_23  75 veltfenkdgrytrsiererelskkkgkt 103
                  +++++n++ +   + +++++ ++k++k+
  EFC36256.1  79 RKRSISNEHQI--ANPKQSKPSTRKETKE 105
                 33333333332..2333333333333333 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.019
      AAA_23 112 leideleqfisellgskkiilnlilflgqerfeefelkdkkerleelek 160
                  ++++ e ++++l ++  i++++i+f+  +++e+++ +d +++l ++++
  EFC36256.1 320 AQVQNMEGNFRQLHNRCSINSEQISFYSGDETERKKVEDYFDKLTDYSN 368
                 5567778888999999999*************9*999*******99986 PP

  == domain 3  score: 14.5 bits;  conditional E-value: 2.4e-05
      AAA_23  13 qeidF.skgltlItGpNGaGKTTildA 38 
                  +++  +k   +I+G NGaGK+++++ 
  EFC36256.1 505 LTFHVnKKEHIVISGSNGAGKSSLFRV 531
                 33333556788*************975 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1       3.8   6.2e+03      25      63 ..     452     493 ..     441     506 .. 0.59
   2 ?   13.2   0.1   3.7e-05      0.06       3      61 ..     516     571 ..     515     602 .. 0.67
   3 ?   -1.2   0.0      0.85   1.4e+03     225     255 ..     611     641 ..     581     648 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.8
      AAA_21  25 l...drdvegltdelsggggirkipslldlydpeipfefeie 63 
                 +   ++ +e  ++ +s + ++r   +   l+++ei+f+  ++
  EFC36256.1 452 VsllFQIIEEIKTGNSQNINFRRNHKGEILDSDEIKFTNVTI 493
                 344555566666666666666666666666666666655444 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.7e-05
      AAA_21   3 vliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldlydpeipfefe 61 
                 v+ G Ng+GKS+L++ l  l   ++  eg+ ++++  g++++  ++  +y p +p ++ 
  EFC36256.1 516 VISGSNGAGKSSLFRVLGSL---WPLHEGSIHKPQACGNNSSGLHKEIFYLPQKPYNLV 571
                 788**************999...555555555555555666666666666666665555 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.85
      AAA_21 225 engdgqelparelSdGtkrllalltallral 255
                 e+g+    ++++lS G ++ lal+ +++  +
  EFC36256.1 611 EHGFETVQDWNSLSRGEQQKLALVRLFYHKP 641
                 7788888999**********99886666555 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   1.8e-05     0.029      88     139 ..     500     552 ..     466     568 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.8e-05
                  TTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT-----S----------- CS
  RsgA_GTPase  88 egleelkellkd.ktsvlvGqSGvGKStLinallpelelktgevseklgrGkh 139
                  + +++l+ ++++ + +v+ G+ G+GKS+L  +l +   l+ g++ + +  G +
   EFC36256.1 500 TLAKNLTFHVNKkEHIVISGSNGAGKSSLFRVLGSLWPLHEGSIHKPQACGNN 552
                  3456788888887899***************9998888888888777777765 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   3.6e-05     0.058      15      39 ..     505     529 ..     494     532 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.6e-05
      AAA_29  15 htieidlkgatlltGpsGsGKSTll 39 
                  t++++ k+ ++++G +G+GKS+l+
  EFC36256.1 505 LTFHVNKKEHIVISGSNGAGKSSLF 529
                 6788888889*************96 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0         2   3.2e+03     106     172 ..      35     101 ..      33     110 .. 0.59
   2 ?   -0.4   0.0      0.37     6e+02     157     184 ..     316     343 ..     309     359 .. 0.79
   3 ?    9.3   0.0   0.00038      0.63       7      35 ..     502     531 ..     496     543 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2
  Zeta_toxin 106 spdvvkklaealkkaG..YevevvvvavkkelSrlgvldRyeeevaegRlvpkeehdeafeglresvea 172
                 s ++ k++ + +k++G  Y++  ++++ +  +    v +R + +  + R ++ e++++  ++ + s+++
  EFC36256.1  35 SLHYWKRILQHFKSNGkvYKILSLALIFSGLVGGYYVSQRQKPS--RKRSISNEHQIANPKQSKPSTRK 101
                 55666667777777664444444455555555555566666666..34778888777777777766666 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.37
  Zeta_toxin 157 eehdeafeglresvealeeekqldrvki 184
                 +++ +++++++ ++++l++++ +++ +i
  EFC36256.1 316 TKFSAQVQNMEGNFRQLHNRCSINSEQI 343
                 678999**************98776555 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00038
  Zeta_toxin   7 dkk.ypsqerPklillgGqpGAGKselael 35 
                 +k+ +   +++  i+++G+ GAGKs+l + 
  EFC36256.1 502 AKNlTFHVNKKEHIVISGSNGAGKSSLFRV 531
                 5555566789999*************9876 PP

>> AAA_27  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00013      0.21      17      49 ..     503     535 ..     500     538 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00013
      AAA_27  17 rsldfsaeeadlhliyGpNEAGKstalrAisdl 49 
                 ++l+f+ ++++  +i G+N AGKs+++r + +l
  EFC36256.1 503 KNLTFHVNKKEHIVISGSNGAGKSSLFRVLGSL 535
                 5799999999999*************9987765 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   0.00014      0.23      18      59 ..     491     532 ..     485     535 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00014
                   TEEEEEEET.TS-EEEEEGGGS-.SEEEE--TTSSHHHHHHHH CS
  FtsK_SpoIIIE  18 lpvalgkei.sgnplvldlkkmashllvaGatgsGKStalntL 59 
                   ++++ + ei   ++l++  +k + h+++ G+ g GKS   ++L
    EFC36256.1 491 VTIKTPDEItLAKNLTFHVNKKE-HIVISGSNGAGKSSLFRVL 532
                   67888899988899999999999.*************998876 PP

>> UDPG_MGDP_dh_N  UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00018       0.3      77     129 ..     118     169 ..      84     190 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00018
                     -SEEEE-----B-TTTTCB-THHHHHHHHHHHHHHHCEEEEEE-S---TTHHH CS
  UDPG_MGDP_dh_N  77 advifiaVgTPskkkgkaaDlkyvesaarsiaealkkgkvvvvkSTvpvgtae 129
                      +++ i   TP+++ +++  l+y++   + i+ ++   ++vv+kS v  +++ 
      EFC36256.1 118 YNLLRIGFKTPTND-DENKSLRYLKGRNKFIGLIVMVSSLVVLKSVVICRSNF 169
                     567789999*****.55569***************************999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (731 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       854  (0.0476323); expected 358.6 (0.02)
Passed bias filter:                      563  (0.0314016); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.76u 0.35s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 4276.47
//
Query:       EFC36257.1  [L=239]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-20   73.8   0.6    2.1e-20   73.6   0.6    1.0  1  Peptidase_S10  Serine carboxypeptidase
  ------ inclusion threshold ------
      0.071   13.5   0.1       0.15   12.5   0.1    1.5  1  TMEM107        Transmembrane protein


Domain annotation for each model (and alignments):
>> Peptidase_S10  Serine carboxypeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.6   0.6   2.3e-24   2.1e-20       7     156 ..      46     219 ..      37     226 .. 0.88

  Alignments for each domain:
  == domain 1  score: 73.6 bits;  conditional E-value: 2.3e-24
                    -SSEEEEEEEECSTTTTEEEEEEEEE-SS...GTTTS-EEEEE--TTTB-THHHHHHTTSSEEEETTTTSEEEE-TT-GGGCSEEEEE--STTSTT CS
  Peptidase_S10   7 vnfkqysGYldveeeedkslFYwfvesek...npeedplvlWLnGGPGCsSldGlleElGPfrvnkdstkkleenpysWnkvanvlfldqPvGvGF 99 
                    +  k+y+G l ++ + + +lFYw++ +++   n e+++l++ Ln GP C   + l+ E+G f+++   ++ l +n+ s ++ a+vl++d+P+G+G 
     EFC36257.1  46 PLPKSYAGNLPIR-SGKDRLFYWYFPKTNsniNDERKDLLVMLNRGPACYFAEMLFLENGVFQID--ANQVLTLNSKSFHQFAHVLYIDSPLGTGL 138
                    44699********.88999******999988889999****************************..679*************************9 PP

                    -EETTSSGS--SH.....................HHHHHHHHHHHHHHHHHSTCG....TTSEEEEEEETTHHHHHHHHHHH CS
  Peptidase_S10 100 Sysntksdvktdd.....................eevaedlyefLkkffekfpey....ksrdfyitGESYaGhyvPalake 156
                    S  +t+ + + +                      + v +dl ++L  ff+ fp++    k +++   +  Y+ +++P++ ke
     EFC36257.1 139 SQFSTEVS-NFESygklmfpgnslrlktvfpgatKYVVKDLQDALIGFFTLFPHLspdkKGSTLNFYTPGYSAKMIPYFIKE 219
                    98888877.333345799**********************************998777666777888888999999999875 PP

>> TMEM107  Transmembrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   1.7e-05      0.15       4      91 ..       2     129 ..       1     132 [. 0.79

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.7e-05
     TMEM107   4 fRflalvahliilvvilyskeeniraalpl......................................dfssseyseertelvvalivsllllvielig 64 
                 fR++a+v+ +ii++  +   +e + + + +                                        ++s++++er+ l v+l  + ++ + e+++
  EFC36257.1   2 FRLVAFVFLFIITISFIHAADEKYSKPTLNeitsipkftptdtnplpksyagnlpirsgkdrlfywyfPKTNSNINDERKDLLVMLNRGPACYFAEMLF 100
                 8*********************77777333444555566667777788888888999999******9999999*************************9 PP

     TMEM107  65 lisGisl..fsatlsllsivlHaigavll 91 
                 l  G+     ++ l+l s  +H ++ vl+
  EFC36257.1 101 LENGVFQidANQVLTLNSKSFHQFAHVLY 129
                 97776331134556666677777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       415  (0.0231469); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1435.19
//
Query:       EFC36258.1  [L=1078]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.5e-40  137.1   0.8    3.4e-33  115.1   0.3    2.9  3  Pkinase      Protein kinase domain
    2.7e-29  102.3   0.0    9.7e-21   74.2   0.0    2.7  3  Pkinase_Tyr  Protein tyrosine kinase
    8.3e-07   28.6   0.0    8.3e-07   28.6   0.0    4.1  5  Kinase-like  Kinase-like
    0.00025   20.5   0.2    0.00083   18.9   0.2    2.0  1  IQ           IQ calmodulin-binding motif
     0.0047   16.3   0.0       0.53    9.6   0.0    3.0  3  Kdo          Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   1.7e-07   0.00059      85     259 ..     179     358 ..     141     360 .. 0.71
   2 ?   -3.0   0.0         1   3.7e+03      29      60 ..     490     522 ..     489     533 .. 0.79
   3 !  115.1   0.3   9.4e-37   3.4e-33       3     260 ..     791    1049 ..     789    1051 .. 0.82

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 1.7e-07
                 HHHHHH..HHSS--HH.HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE....EEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH..... CS
     Pkinase  85 ladlle..rkgslsee.eakkiakqilegleylHskgiiHrDlKpeNiLid.ekge....lKitDFGlakelesssk.ltsfvgtseYlAPEvl..... 169
                 +++lle   +  +s+   + k+++ +++gl+ lH+kg+ H  + p Ni +  ++g       +  FGl ++++  ++  +s      Y +P v      
  EFC36258.1 179 VEELLEsgSELLFSDLnCIVKLFSDLASGLSELHAKGLTHNSILPRNITMFhTEGGfeflTTVPSFGLDNNVDGVNDdHMS------YFSPQVYsrfee 271
                 455555433334444314569999************************6652444479988999********997754444......555555544433 PP

                 .TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 170 .keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                   e+ ++++ Dv+ lG +++ +l g++  +++ +++   +e+ +++k + i +    k+++ ++  e ++dl  ++++  + +R+t++e++
  EFC36258.1 272 gVEEVFTTQNDVFMLGTLFMRILLGEEFDAKQIDSDYWDSEIGDFKK-TIIAR--FGKIATGTK-IEILTDLACRCVSPSEDSRPTIDEIV 358
                 256888********************988877776666667777322.22222..123333333.57899*****************9986 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1
                 EEEEECHCHCHHHH.HHHHHHHHHHHHHSCTTB CS
     Pkinase  29 vKkikkekakkkke.kkvlrEikilkklkhpni 60 
                 vK+i+k++++k++  ++ ++E  +l ++ ++++
  EFC36258.1 490 VKQISKKSDSKQSSsSSSTQEYDMLSRTTSNKL 522
                 688888888877777899999999999887765 PP

  == domain 3  score: 115.1 bits;  conditional E-value: 9.4e-37
                  EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE........SSEEEEEEE--TTEBHHHHHH. CS
     Pkinase    3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee........kdelylvleyveggeladlle. 90  
                  ++++l  G+++ ++++++k+tg+  ++K++++  +++     +lrE+k lk ++h+niv++++ f+          ++ ++++ey+  g+l +l   
  EFC36258.1  791 VQKRLSDGASAIILQVKDKDTGDVHVMKRFREGVESD-----YLREVKCLKLFSHKNIVQFVDNFSYtettdgksVKSNIVIMEYCTFGDLYKLSMs 882 
                  6788999***********************9998776.....899******************9998899999985666679********9998877 PP

                  ....HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHH CS
     Pkinase   91 ....rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWsl 183 
                      + + + + ++ k++ q++e+++++H+ g++H D+Kp+Ni++ ++g lK++DFG+  + +     t   gt +Yl+ E  ++++   ++D++s+
  EFC36258.1  883 fttgKPKPMRPLRMLKFTLQLFEAIAHIHEYGFVHSDIKPQNIFLAKDGTLKLGDFGFTVKEKD----TVAGGTLHYLPVEQEEGQPAVLASDLYSA 975 
                  765555556677888*******************************************877666....6799************************* PP

                  HHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH.....HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase  184 Gvilyelltgkppfsgekgkekvekeldqlekilkilgetk..eklpeaseiseeakdllkkllkkdpkkRltaeellq 260 
                  ++ ++e+l +k +  ++k+   + + ++   ++ +  ++++  ++ ++ +     + ++ k++l+ d++kR  ++e+++
  EFC36258.1  976 ACSMFEVLVKKKVSLKSKQG--APTSFE---EVWDQHNKNNihFHRKKYNPHAMGLFEVFKNCLETDHTKRRPVKEIVE 1049
                  *********99998733322..222222...23333334340044444444467778999***********99999886 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.0   2.6e-09   9.2e-06     103     258 ..     195     360 ..     173     361 .. 0.85
   2 ?   -3.2   0.0       1.1   4.1e+03      33      70 ..     490     529 ..     484     534 .. 0.70
   3 !   74.2   0.0   2.7e-24   9.7e-21      35     259 .]     819    1051 ..     791    1051 .. 0.77

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 2.6e-09
                  HHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHH CS
  Pkinase_Tyr 103 kdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvll 195
                  + ++++  ++A+G++ L++k l H  +  rN+ + +     + +  +  fGL +++  d    ++ +   p  +   E   e++ft++ Dv++ G+l 
   EFC36258.1 195 NCIVKLFSDLASGLSELHAKGLTHNSILPRNITMFHteggfEFLTTVPSFGLDNNV--DGVNDDHMSYFSPQVYSRFEEGVEEVFTTQNDVFMLGTLF 290
                  45788999************************9887677777799***********..8888899999****************************** PP

                  HHHHTTSSGT........TTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHH CS
  Pkinase_Tyr 196 wEiftlgesp........ypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvek 258
                  + i+  ge+         y++ +  ++ +++ ++    +  +  e l++l  +c + + ++Rpt+ e+v  
   EFC36258.1 291 MRILL-GEEFdakqidsdYWDSEIGDFKKTIIARFGKIATGTKIEILTDLACRCVSPSEDSRPTIDEIVGI 360
                  *9997.5544455555557777777788888666555555667788999****************999865 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.1
                  EEEESTTSSHHH..HHHHHHHHHHHHTS-BTTB--EEEEE CS
  Pkinase_Tyr  33 vKtlkeeateee..keelleeakimkklkhpnivkllgvc 70 
                  vK++++++++++  +++ ++e+++++++  +++   +g++
   EFC36258.1 490 VKQISKKSDSKQssSSSSTQEYDMLSRTTSNKLSTPTGAV 529
                  6777544444432277888899999999888887777766 PP

  == domain 3  score: 74.2 bits;  conditional E-value: 2.7e-24
                   EESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE....SSSS......EEEEEE--TTEBHHHHHHHT...CTTTSBHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr   35 tlkeeateeekeelleeakimkklkhpnivkllgvct....keep......llivteyvkgGdLlkfLrkk...ekekltlkdllsfalqvAkGme 117 
                    ++e      +++ l+e+k++k ++h+niv+++   +               ++++ey++ GdL k   +    + ++++  ++l+f+lq+ ++++
   EFC36258.1  819 RFRE----GVESDYLREVKCLKLFSHKNIVQFVDNFSytetT--DgksvksNIVIMEYCTFGDLYKLSMSFttgKPKPMRPLRMLKFTLQLFEAIA 908 
                   3333....335679******************9988755441..13456669**********9987422223337999****************** PP

                   HHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTS.... CS
  Pkinase_Tyr  118 yLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypgl.... 209 
                   ++++  +vH d+  +N++l+++ + k++DfG + +        k++ a   ++++++E  + +    +sD +s +  ++E++ + + ++++     
   EFC36258.1  909 HIHEYGFVHSDIKPQNIFLAKDGTLKLGDFGFTVKE-------KDTVAGGTLHYLPVEQEEGQPAVLASDLYSAACSMFEVLVKKKVSLKSKqgap 997 
                   ********************************9877.......5556667899*****************************98887755442201 PP

                   .HHHHHHHHH.HTTEES-BBTTSBHH..HHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  210 .kneevlekl.kegkrlekpekcpee..lyelmkkcweedpeeRptfselvekl 259 
                    + eev ++  k++ + ++ ++ p++  l e+ k+c+e+d ++R   +e+ve+l
   EFC36258.1  998 tSFEEVWDQHnKNNIHFHRKKYNPHAmgLFEVFKNCLETDHTKRRPVKEIVETL 1051
                   1233455444344444566666655422789*******************9986 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.17   5.9e+02     121     156 ..      55      92 ..      26      96 .. 0.77
   2 ?    2.5   0.0     0.021        75     159     186 ..     210     239 ..     196     294 .. 0.75
   3 ?   -5.6   1.8         5   1.8e+04      32      62 ..     608     638 ..     582     644 .. 0.55
   4 ?    2.5   0.1     0.021        75      10      45 ..     785     820 ..     777     831 .. 0.84
   5 !   28.6   0.0   2.3e-10   8.3e-07     147     198 ..     897     948 ..     874     959 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.17
  Kinase-like 121 svdleilnkvlqkrset..hkkletiarlllTlqlirl 156
                  s+dl +++++l++ +++  +   +   r l+ +q+i +
   EFC36258.1  55 SLDLSRMMNTLKFIQSReeQTGKVLETRSLISMQVISV 92 
                  6899999****999999556666777899999999987 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.021
  Kinase-like 159 nLqakglvhgkftvdnl.lldekggl.mlg 186
                  +L+akgl h+ + ++n+ +++ +gg+ +l+
   EFC36258.1 210 ELHAKGLTHNSILPRNItMFHTEGGFeFLT 239
                  79**************84688999984455 PP

  == domain 3  score: -5.6 bits;  conditional E-value: 5
  Kinase-like  32 kdqetgeplavkvfllpseaskkdlerlkeq 62 
                  +++ + ++ ++   + ++e  kk+le+lk++
   EFC36258.1 608 NNELKAKKDQIEEEINEEEERKKQLEKLKKK 638
                  4444455555555555666666677776665 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.021
  Kinase-like  10 rertlvrgellkkgdrsvvfevkdqetgeplavkvf 45 
                  ++ ++++++ l +g + ++++vkd+ tg+  ++k f
   EFC36258.1 785 KKEKYIVQKRLSDGASAIILQVKDKDTGDVHVMKRF 820
                  45677888899*****************99888877 PP

  == domain 5  score: 28.6 bits;  conditional E-value: 2.3e-10
  Kinase-like 147 lllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkv 198
                  l  Tlql   +a+++++g vh +++++n++l ++g l+lg+f+  v+ ++ v
   EFC36258.1 897 LKFTLQLFEAIAHIHEYGFVHSDIKPQNIFLAKDGTLKLGDFGFTVKEKDTV 948
                  568****************************************999998876 PP

>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.2   2.3e-07   0.00083       2      21 .]    1058    1077 ..    1057    1077 .. 0.94

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 2.3e-07
                  HHHHHHHHHHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRGylaRkryk 21  
                   +a+  Q+++RGy aRk +k
  EFC36258.1 1058 HSATMVQKRYRGYHARKSFK 1077
                  69***************997 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.014        51      99     155 ..     173     232 ..     170     239 .. 0.79
   2 ?   -3.0   0.0       1.1   3.9e+03      51      79 ..     500     528 ..     489     533 .. 0.77
   3 !    9.6   0.0   0.00015      0.53      60     155 ..     830     931 ..     815     941 .. 0.68

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.014
         Kdo  99 legaqdLedllakwae...laeelkrallkavgrliaklhragvnHadlyaknillqqee 155
                 l++++++e+ll++++e    + +   +l+ +++   ++lh+ g+ H  + ++ni +  +e
  EFC36258.1 173 LNNVKSVEELLESGSEllfSDLNCIVKLFSDLASGLSELHAKGLTHNSILPRNITMFHTE 232
                 77888888888888887655666777889999999*******************765543 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.1
         Kdo  51 fklgrtravrEfrllkrLeeagvavpkpv 79 
                  + +   + +E+++l r  + ++ +p+ +
  EFC36258.1 500 KQSSSSSSTQEYDMLSRTTSNKLSTPTGA 528
                 446778899***************99875 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00015
         Kdo  60 rEfrllkrLeeagvavpkpvaagavkvgle.yrAlllterlegaqdLedllakwae..laeelkrallk...avgrliaklhragvnHadlyaknillq 152
                 rE++ lk + ++ +      +++ +  +++  ++ +++ +   + dL +l+ ++ +  ++  +  ++lk   ++  +ia +h+ g  H d+ ++ni+l 
  EFC36258.1 830 REVKCLKLFSHKNIVQFVDNFSYTETTDGKsVKSNIVIMEYCTFGDLYKLSMSFTTgkPKPMRPLRMLKftlQLFEAIAHIHEYGFVHSDIKPQNIFLA 928
                 566666666555554444444444444444477777777777777777777777766655555555555333666789********************9 PP

         Kdo 153 qee 155
                 +++
  EFC36258.1 929 KDG 931
                 987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1078 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2638  (0.147136); expected 358.6 (0.02)
Passed bias filter:                      675  (0.0376485); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.12u 0.36s 00:00:01.48 Elapsed: 00:00:00.54
# Mc/sec: 6032.22
//
Query:       EFC36259.1  [L=242]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-50  170.1   0.3    7.2e-50  169.6   0.3    1.1  1  DUF924    Bacterial protein of unknown function (DUF924)
  ------ inclusion threshold ------
       0.15   12.2   0.1       0.29   11.3   0.1    1.4  1  DUF2255   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF924  Bacterial protein of unknown function (DUF924)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.6   0.3     8e-54   7.2e-50       1     175 [.      16     236 ..      16     237 .. 0.96

  Alignments for each domain:
  == domain 1  score: 169.6 bits;  conditional E-value: 8e-54
      DUF924   1 vldfWfee...........eakekakrwfkk......keefDaeirerfesllea.........................aaageldewakepegaLal 57 
                 v++fWf++             ke+++ wf++      k+++D++i+e++esl  +                         a+ ++ +ew ++p+g+++l
  EFC36259.1  16 VYSFWFGKitayehrvridGIKESMSVWFSAgkdpeqKKQLDSDIKEQYESLAISgremakkllttiqdnssttfneevfAELTKSSEWFSSPKGMISL 114
                 789***************9889********999999999*************9999*********************99877888889*********** PP

      DUF924  58 iillDQfpRniyRgtakafatDalAlalakealek.gldeeleeaerlffylplmHsEdladqeravelfeelaeeveeeee...eeslkfakkhrdii 152
                 iil+DQf+Rn+yRg a+++++D  Ala++k++l++ +l +++++ e++f++lpl+HsE+l +qe++++++e l ee++e+ +   + ++k+a++h+d+i
  EFC36259.1 115 IILFDQFSRNMYRGLAESYSFDMYALAISKRILSDrQLYNSFKTFEKIFLLLPLEHSENLMNQEQCIQEYELLVEEAPEDLKgffQYFVKYARMHHDLI 213
                 ********************************9765999**************************************99999***************** PP

      DUF924 153 erFgRyPhRNaaLgResteeEke 175
                 e+FgR+P RN +LgRest+eE e
  EFC36259.1 214 EKFGRFPFRNPILGRESTPEELE 236
                 *********************86 PP

>> DUF2255  Uncharacterized protein conserved in bacteria (DUF2255)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   3.3e-05      0.29      46      95 ..      17      67 ..      12      83 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3.3e-05
     DUF2255 46 askWyraalaqkagriraggve..kdVtfeeeadkelndkidaaYraKYary 95
                 s W+ + +a +  r+r++g++    V f + +d+e ++++d+  +++Y+  
  EFC36259.1 17 YSFWFGKITAYE-HRVRIDGIKesMSVWFSAGKDPEQKKQLDSDIKEQYESL 67
                577999877654.566666655116899999******************943 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (242 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       739  (0.0412181); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1511.08
//
Query:       EFC36260.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       638  (0.0355848); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.42u 0.31s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1077.42
//
Query:       EFC36261.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.26s 00:00:00.70 Elapsed: 00:00:00.44
# Mc/sec: 1199.86
//
Query:       EFC36262.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00057   20.5   0.0    0.00077   20.1   0.0    1.2  1  Abhydrolase_6  Alpha/beta hydrolase family
    0.00079   19.1   0.0     0.0013   18.4   0.0    1.4  1  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
       0.03   13.6   0.0      0.056   12.7   0.0    1.4  1  Hydrolase_4    Serine aminopeptidase, S33
      0.056   13.3   0.0       0.24   11.2   0.0    1.9  2  Pox_LP_H2      Viral late protein H2


Domain annotation for each model (and alignments):
>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.0   1.7e-07   0.00077       2      81 ..     101     192 ..     100     250 .. 0.76

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 1.7e-07
                    EEE--GC.....GC..HHHHHHHHCCT...CEEEEE--TTSTS-....GGCS--HHH....CHHHHHHHCCTT.....TTSE..EEEEETCHHHHH CS
  Abhydrolase_6   2 lllHGagssassWl..vapLaallaag...vhvlapDlpGhGrs....dpppldled....ladlaalldelaa...gggpv..vlvGHSlGGala 79 
                     llHG+g++  sW+  + +L     +    v  +a+DlpG+G s      +++ +++    l+  +++l el +   +++++  +++ HS+ ++++
     EFC36262.1 101 YLLHGFGGNTFSWRmnAEEL----ISKfdlV--VAIDLPGFGYSsreiGLKHTRWNRafwgLQVMRRTLLELETyskQDCEIscFIMSHSMSCVYS 190
                    69***********3334455....4444556..7********662333445588888544335557777777777886666678999999999876 PP

                    HH CS
  Abhydrolase_6  80 la 81 
                     +
     EFC36262.1 191 PE 192
                    66 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0     3e-07    0.0013       2      49 ..      99     144 ..      98     175 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3e-07
                    EEEEE-STTTCGGGGTTGHHHHHHHHTTSE.EEEEEETTSTTSSSTTTG CS
  Abhydrolase_1   2 vlvilhGlpgssdvwaerglapaLakdgfd.villDlrGvgySspapac 49 
                    vl +lhG++g+  +w+    a+ L   +fd v+++Dl+G+gySs+ +  
     EFC36262.1  99 VLYLLHGFGGNTFSWRM--NAEELIS-KFDlVVAIDLPGFGYSSREIGL 144
                    899*********99999..8889988.8884679***********9865 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.3e-05     0.056       4      85 ..      97     185 ..      94     201 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.3e-05
  Hydrolase_4   4 kavvvlvHGlaehsgryaelaeaLaaqGfavyalDhrGhGrsegkrg.hvpsfddyvdDlaafv......ekvkeehpelplfllGhSm 85 
                   +v+ l+HG++         ae+L  +   v+a+D  G+G s  + g + +++++    l+ +       e+  ++  e  +f++ hSm
   EFC36262.1  97 AKVLYLLHGFGGNTFSWRMNAEELISKFDLVVAIDLPGFGYSSREIGlKHTRWNRAFWGLQVMRrtllelETYSKQDCEISCFIMSHSM 185
                  67899**********************99**************77776788888888888888622222244444444449*******9 PP

>> Pox_LP_H2  Viral late protein H2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0      0.89     4e+03      13      44 ..     209     240 ..     206     256 .. 0.67
   2 ?   11.2   0.0   5.4e-05      0.24     130     167 ..     266     303 ..     260     308 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.89
   Pox_LP_H2  13 leyvrekeaksiraakvstliffvlilaisvl 44 
                 l+y+ + ++k  r+ k + l+f+  +  + +l
  EFC36262.1 209 LHYLSKDSSKFERFFKITNLVFVSGMYYVQTL 240
                 67777777777888888888877666666555 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 5.4e-05
   Pox_LP_H2 130 dgWmvkkaakvdlsaqqfceyvvrnksdnvitcGleml 167
                 + Wm+kka +++++ +    y++ +  +n++ c ++m 
  EFC36262.1 266 NKWMLKKAYNRNPTDEEVFGYLLPTDLKNSVDCLMDMT 303
                 68********************************9995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       863  (0.0481343); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.25s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2217.20
//
Query:       EFC36263.1  [L=377]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00058   19.6   0.2     0.0016   18.1   0.1    1.7  2  Abhydrolase_1  alpha/beta hydrolase fold
      0.001   19.7   0.0     0.0037   17.9   0.1    1.8  2  Abhydrolase_6  Alpha/beta hydrolase family
     0.0026   17.1   0.0     0.0084   15.4   0.0    1.8  2  Hydrolase_4    Serine aminopeptidase, S33


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.1   2.7e-07    0.0016       2      49 ..      90     135 ..      89     160 .. 0.89
   2 ?   -1.5   0.0      0.27   1.6e+03     153     236 ..     218     308 ..     187     318 .. 0.55

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 2.7e-07
                    EEEEE-STTTCGGGGTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTG CS
  Abhydrolase_1   2 vlvilhGlpgssdvwaerglapaLakdgfdvillDlrGvgySspapac 49 
                    v++++hG + s   w+    ++ L ++   v+++Dl+G+g+Ss+ +  
     EFC36263.1  90 VVLLVHGVGSSTAGWRH--CIDSLLEKYEMVVAMDLPGFGFSSRTIGL 135
                    89***************..99999997888*************99865 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.27
                    HHHHHHHHHHHHCHHHCCHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHC...THHHHS...EEEEEEETTCSSSCH.HHHHHHHHC CS
  Abhydrolase_1 153 qrhrlvdalkfpdkskrfpssgsdnasslatgalksieqwpttdsaklllrlre...lknvla...ptlvisgtsDplvpp.kaledlaql 236
                    ++++++ ++ + ++++++ +++ +  +++++ +   +++++ ++++  ll++ +   ++n +    ++l+   ++D  ++  k+le l+ql
     EFC36263.1 218 YFQSNLSEMLSYSVVQSITRMTLRMIMGKTAMSFILKSSFNRNPTNEELLSYTIpigIQNSIDcfvDILISFKADDEQFSMeKHLEILNQL 308
                    4444444444444444444444444444444444444455555555555555556665555555778888777777777777887777776 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.1   6.2e-07    0.0037       1      43 [.      91     132 ..      91     184 .. 0.72
   2 ?   -1.3   0.0      0.45   2.7e+03     195     211 ..     347     362 ..     296     370 .. 0.69

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 6.2e-07
                    EEEE--GC.....G.CHHHHHHHHCCT..CEEEEE--TTSTS-GGC CS
  Abhydrolase_6   1 vlllHGagssassW.lvapLaallaag..vhvlapDlpGhGrsdpp 43 
                    vll+HG gss  +W +   +  ll +   v  +a+DlpG+G+s++ 
     EFC36263.1  91 VLLVHGVGSSTAGWrH--CIDSLLEKYemV--VAMDLPGFGFSSRT 132
                    89************65..444444444688..9********66443 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.45
                    TEEETCE...SSS-HHH CS
  Abhydrolase_6 195 garlpvvlpgaGHlphl 211
                    ++++ +++++a+H++++
     EFC36263.1 347 KFVY-KLFENASHCLME 362
                    3344.8999*****998 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   1.4e-06    0.0084       5      50 ..      89     134 ..      86     173 .. 0.79
   2 ?   -2.4   0.0      0.37   2.2e+03     197     235 ..     317     361 ..     299     364 .. 0.62

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 1.4e-06
  Hydrolase_4   5 avvvlvHGlaehsgryaelaeaLaaqGfavyalDhrGhGrsegkrg 50 
                   vv+lvHG++++     + ++ L ++   v+a+D  G+G s    g
   EFC36263.1  89 RVVLLVHGVGSSTAGWRHCIDSLLEKYEMVVAMDLPGFGFSSRTIG 134
                  589**************************************85444 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.37
  Hydrolase_4 197 lhGeaDkvvdpeas...relyerlgsk...dktlklypglyHell 235
                  + ++ D+v ++e++   + ++e++ s+   +  +kl++++ H l+
   EFC36263.1 317 IVAKLDNVHSMEEAlkfKTILESQESSkngKFVYKLFENASHCLM 361
                  456666777776665554445555444333445677777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       821  (0.0457917); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 2550.43
//
Query:       EFC36264.1  [L=1179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-22   79.4   1.1    1.5e-10   41.3   0.2    2.5  2  BTB       BTB/POZ domain
    1.8e-19   69.5   3.2      3e-07   30.3   0.0    5.8  6  Kelch_4   Galactose oxidase, central domain
    1.4e-15   56.9   3.1    0.00018   21.4   0.0    4.6  4  Kelch_5   Kelch motif
    1.7e-15   56.7   7.1    4.6e-07   29.9   0.0    5.7  5  Kelch_6   Kelch motif
    1.2e-14   53.6   5.3    4.8e-05   22.8   0.0    5.0  5  Kelch_1   Kelch motif
    9.8e-13   48.0   0.6    4.8e-06   26.7   0.0    4.7  4  Kelch_3   Galactose oxidase, central domain
    2.1e-07   30.6   6.5     0.0017   18.2   0.0    4.6  5  Kelch_2   Kelch motif
     0.0014   18.6   2.2     0.0026   17.7   2.2    1.4  1  LodA_N    L-Lysine epsilon oxidase N-terminal
  ------ inclusion threshold ------
       0.14   12.3   5.6       0.38   10.9   0.1    3.7  4  BACK      BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.3   0.0   2.7e-12   5.4e-09       9      91 ..     848     940 ..     839     952 .. 0.82
   2 !   41.3   0.2   7.3e-14   1.5e-10       8     110 ..     997    1102 ..     991    1103 .. 0.93

  Alignments for each domain:
  == domain 1  score: 36.3 bits;  conditional E-value: 2.7e-12
                 TTS-EEEEETT.....TEEEEE-HHHHHHH-HHHHHHHTST....TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-...CGGGHHHHHHHH CS
         BTB   9 elcDvtlvvgd.....gkefkahkavLaarSpyFkalftsk....eieessvseielddvepeafealLefiYtgeleit...seenleelLaaa 91 
                 +  D++l+v +     ++ +++hk+ +++rS+yFk+l+ +     +   +++s  el+d + +++ ++++f+Ytg + i+   ++e l+elL++ 
  EFC36264.1 848 SGYDLILKVAErtsgeTEYIYVHKCLVSSRSTYFKDLLVGLndvdM--VDGKSIFELNDYHLDTMNIFIRFLYTGDIIIPdtvNTECLQELLNIS 940
                 5568888888888888999********************9977532..333347999***********************888888888888764 PP

  == domain 2  score: 41.3 bits;  conditional E-value: 7.3e-14
                  TTTS-EEEEETT......TEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HH CS
         BTB    8 gelcDvtlvvgd......gkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqipr 98  
                  + + Dvt+++ d        e++ahk++ + rS+y ++ f+s+ +ee ++ +i+ d+++ + + ++L+++Yt e+ ++  e ++e++ +  l+q+++
  EFC36264.1  997 NNYADVTIQLLDphtgelLNELRAHKLFIC-RSNYISTVFSSG-MEETTTGVIKFDEISLNGLLSVLKYLYTNEIIVS-IEHAVEVFICSLLFQLNE 1090
                  5799*****999999888779******986.9***********.8999999**************************6.****************** PP

                  HHHHHHHHHHHH CS
         BTB   99 lkkaceeflkqs 110 
                  l++ c ++++q+
  EFC36264.1 1091 LANYCRTIVIQH 1102
                  *******99886 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.4   2.9e+03      26      42 ..     304     320 ..     300     325 .. 0.86
   2 ?   -0.4   0.0      0.61   1.2e+03      15      42 ..     484     510 ..     478     516 .. 0.77
   3 !    5.9   0.1    0.0067        13       5      44 ..     601     642 ..     599     646 .. 0.67
   4 !   30.3   0.0   1.5e-10     3e-07       1      48 [.     667     717 ..     667     719 .. 0.83
   5 !   20.0   0.0   2.6e-07   0.00051       4      45 ..     721     765 ..     720     769 .. 0.83
   6 !    7.5   0.0     0.002         4       1      22 [.     785     805 ..     785     812 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.4
     Kelch_4  26 tllndlylldlstntWr 42 
                  +++d + ++ + n+W+
  EFC36264.1 304 YCSDDDDEYNEEENEWS 320
                 588999**********6 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.61
     Kelch_4  15 iylfGGrgedgtllndlylldlstntWr 42 
                 ++l GG  + g +++ l  + ++ ++W 
  EFC36264.1 484 VFLSGGGKS-GRIYSQLVCYEVKEKKWV 510
                 455555555.69***************5 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0067
     Kelch_4   5 hsatsipdg.tiylfGGrgedgtllndlylldlstn.tWrrl 44 
                 hs+   ++  +++ fGGr  +g l n    ++   +  W+++
  EFC36264.1 601 HSLSKSNNEpKFWSFGGRDVNGVLTNQFVEYNMVRRtFWSKV 642
                 5555553323899********855555555998888345665 PP

  == domain 4  score: 30.3 bits;  conditional E-value: 1.5e-10
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedg.tllndlylldlstntWrrl...gslP 48 
                 pR +h+ + ++ ++i++fGG +++   llndl+++d+ +++W ++     +P
  EFC36264.1 667 PRENHAQCTVG-NSIFIFGGNYTQKdNLLNDLHRYDIVSKKWNEIdltFIPP 717
                 56678877785.9***********67****************9997774444 PP

  == domain 5  score: 20.0 bits;  conditional E-value: 2.6e-07
     Kelch_4   4 ghsatsipdgtiylfGGrgedgtllndlylldlstntWrrl...g 45 
                 +hs++ + d +iyl+GG+   +t+++ +y++d+++n++  +   g
  EFC36264.1 721 NHSLCNCIDQYIYLTGGILRGNTISDVIYRFDVKNNEFAVInpgG 765
                 899999988***********87788888*********98775433 PP

  == domain 6  score: 7.5 bits;  conditional E-value: 0.002
     Kelch_4   1 pRaghsatsipdgtiylfGGrg 22 
                 pRa+h++ +++ g +y++GG +
  EFC36264.1 785 PRADHTTLYDQ-GQLYMIGGMT 805
                 9*********7.********66 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.2      0.64   1.3e+03      11      28 ..     478     493 ..     471     500 .. 0.76
   2 !   21.4   0.0   9.1e-08   0.00018       1      39 [.     664     702 ..     664     704 .. 0.97
   3 !   20.5   0.1   1.8e-07   0.00036       1      42 []     715     756 ..     715     756 .. 0.95
   4 !   11.4   0.0   0.00012      0.24       4      34 ..     785     816 ..     784     820 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.64
     Kelch_5  11 vtvsekiYvyGGkvgrdg 28 
                  ++++ +++ GG ++  g
  EFC36264.1 478 SAHGSLVFLSGGGKS--G 493
                 578899******996..3 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 9.1e-08
     Kelch_5   1 iPppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdl 39 
                 iP pR +h+ +tv+++i+++GG  ++ +++ +d++++d+
  EFC36264.1 664 IPLPRENHAQCTVGNSIFIFGGNYTQKDNLLNDLHRYDI 702
                 7***********************9************96 PP

  == domain 3  score: 20.5 bits;  conditional E-value: 1.8e-07
     Kelch_5   1 iPppRaghcavtv.sekiYvyGGkvgrdgsvsddvyvLdlpsf 42 
                 iPpp ++h+ + + +++iY++GG+  r++ +sd +y++d++++
  EFC36264.1 715 IPPPMRNHSLCNCiDQYIYLTGGIL-RGNTISDVIYRFDVKNN 756
                 7**********988***********.9*************976 PP

  == domain 4  score: 11.4 bits;  conditional E-value: 0.00012
     Kelch_5   4 pRaghcavtvsekiYvyGGkvg.rdgsvsddv 34 
                 pRa+h + ++ +++Y++GG++     s++ +v
  EFC36264.1 785 PRADHTTLYDQGQLYMIGGMTDyAKRSYCKEV 816
                 9*******************955566665555 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.081   1.6e+02      10      40 ..     480     509 ..     475     511 .. 0.83
   2 ?    3.0   0.1     0.067   1.3e+02       3      44 ..     599     643 ..     598     652 .. 0.86
   3 !   29.9   0.0   2.3e-10   4.6e-07       8      43 ..     674     710 ..     667     721 .. 0.86
   4 !   12.3   0.1   8.3e-05      0.17       4      40 ..     721     758 ..     717     763 .. 0.85
   5 !    7.8   0.0    0.0021       4.2       1      23 [.     785     807 ..     785     814 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.081
     Kelch_6  10 vggkiYifGGytdsspylnkvwvydpetksW 40 
                 +g+ +++ GG +  +  ++++ +y ++ k+W
  EFC36264.1 480 HGSLVFLSGGGKS-GRIYSQLVCYEVKEKKW 509
                 5667777777777.9999************* PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.067
     Kelch_6   3 aghslvsvgg..kiYifGGytdsspylnkvwvydpetks.Weqlp 44 
                 +ghsl   ++  k++ fGG++  +  +n++  y++  ++ W++++
  EFC36264.1 599 TGHSLSKSNNepKFWSFGGRDVNGVLTNQFVEYNMVRRTfWSKVQ 643
                 6788888888789*******9889999999999999999777775 PP

  == domain 3  score: 29.9 bits;  conditional E-value: 2.3e-10
     Kelch_6   8 vsvggkiYifGGytds.spylnkvwvydpetksWeql 43 
                 ++vg++i+ifGG++ + ++ ln++++yd+ +k+W ++
  EFC36264.1 674 CTVGNSIFIFGGNYTQkDNLLNDLHRYDIVSKKWNEI 710
                 89************99******************986 PP

  == domain 4  score: 12.3 bits;  conditional E-value: 8.3e-05
     Kelch_6   4 ghslvs.vggkiYifGGytdsspylnkvwvydpetksW 40 
                  hsl+  ++ +iY+ GG   +++ ++ ++++d++++ +
  EFC36264.1 721 NHSLCNcIDQYIYLTGGILRGNTISDVIYRFDVKNNEF 758
                 5788664889*********99**************987 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.0021
     Kelch_6   1 praghslvsvggkiYifGGytds 23 
                 pra h++   +g++Y++GG td+
  EFC36264.1 785 PRADHTTLYDQGQLYMIGGMTDY 807
                 6999****************994 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       3.3   6.5e+03      32      40 ..     312     320 ..     311     321 .. 0.89
   2 !    6.4   0.0    0.0034       6.8       9      44 ..     479     514 ..     475     516 .. 0.90
   3 !   22.8   0.0   2.4e-08   4.8e-05       2      41 ..     668     709 ..     667     710 .. 0.93
   4 !   17.8   0.1   9.4e-07    0.0019       1      43 [.     719     762 ..     719     764 .. 0.91
   5 !    5.3   0.0    0.0071        14       1      22 [.     785     806 ..     785     819 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.3
                 EETTTTEEE CS
     Kelch_1  32 yDpetntWr 40 
                 y+ e+n+W+
  EFC36264.1 312 YNEEENEWS 320
                 8999****8 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0034
                 EETTEEEEEEEBCSSSBEEEEEEEETTTTEEEEECC CS
     Kelch_1   9 vvggkiYviGGsdggnalssvevyDpetntWrelps 44 
                 ++g  ++  GG+ +g+  s + +y +++++W  + +
  EFC36264.1 479 AHGSLVFLSGGGKSGRIYSQLVCYEVKEKKWVDMKE 514
                 67889999***********************99875 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 2.4e-08
                 BBSEEEEEETTEEEEEEEBCS..SSBEEEEEEEETTTTEEEE CS
     Kelch_1   2 ragagavvvggkiYviGGsdg..gnalssvevyDpetntWre 41 
                 r +++ ++vg+ i+++GG      n l+++ +yD ++++W e
  EFC36264.1 668 RENHAQCTVGNSIFIFGGNYTqkDNLLNDLHRYDIVSKKWNE 709
                 678888**********************************97 PP

  == domain 4  score: 17.8 bits;  conditional E-value: 9.4e-07
                 BBBSEEEEEETTEEEEEEEBCS.SSBEEEEEEEETTTTEEEEEC CS
     Kelch_1   1 aragagavvvggkiYviGGsdg.gnalssvevyDpetntWrelp 43 
                 +r +  + +++ +iY  GG  + ++ ++ ++++D+++n++  ++
  EFC36264.1 719 MRNHSLCNCIDQYIYLTGGILRgNTISDVIYRFDVKNNEFAVIN 762
                 57888899******************************987665 PP

  == domain 5  score: 5.3 bits;  conditional E-value: 0.0071
                 BBBSEEEEEETTEEEEEEEBCS CS
     Kelch_1   1 aragagavvvggkiYviGGsdg 22 
                 +ra ++  + +g++Y iGG+ +
  EFC36264.1 785 PRADHTTLYDQGQLYMIGGMTD 806
                 79*****************988 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.75   1.5e+03       3      32 ..     483     510 ..     481     516 .. 0.87
   2 ?    2.7   0.0      0.08   1.6e+02       3      45 ..     611     672 ..     609     676 .. 0.51
   3 !   26.7   0.0   2.4e-09   4.8e-06       1      47 [.     677     725 ..     677     725 .. 0.91
   4 !   12.5   0.1   7.1e-05      0.14       2      47 ..     730     792 ..     729     794 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.75
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydldtntWa 32 
                  ++++GG    ++  ++++  y +   +W 
  EFC36264.1 483 LVFLSGGGK--SGRIYSQLVCYEVKEKKWV 510
                 689999999..9**********99999996 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.08
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydldtn....................tWaeiaslppaRagha 45 
                 +++ fGG++  ++  +n++ +y+ ++                     ++a+    p +R +ha
  EFC36264.1 611 KFWSFGGRDV-NGVLTNQFVEYNMVRRtfwskvqngviefsmtrdlaNIANPKAIPLPRENHA 672
                 6788999995.5666666666655443222222222222211111445555566677777776 PP

  == domain 3  score: 26.7 bits;  conditional E-value: 2.4e-09
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaei..aslppaRaghaat 47 
                 g++++ifGG+ ++  + lnd+++yd+++ +W ei     pp+ ++h+++
  EFC36264.1 677 GNSIFIFGGNYTQKDNLLNDLHRYDIVSKKWNEIdlTFIPPPMRNHSLC 725
                 799********9989999****************55556********98 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 7.1e-05
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWaei..................aslppaRaghaat 47 
                  ++y++GG  + g++ +   y++d+ +n++a i                   +l+ +Ra h++ 
  EFC36264.1 730 QYIYLTGGILR-GNTISDVIYRFDVKNNEFAVInpggpseyvlygngittpRDLQLPRADHTTL 792
                 69********5.899999999*******999555443333344433333345556677766665 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.3       2.6   5.1e+03      34      43 ..     311     320 ..     306     322 .. 0.83
   2 ?   -3.6   0.0       6.6   1.3e+04      14      45 ..     484     512 ..     479     513 .. 0.67
   3 !   18.2   0.0   8.8e-07    0.0017       4      44 ..     670     709 ..     667     711 .. 0.92
   4 !    8.5   0.0   0.00099         2       3      47 ..     720     763 ..     718     765 .. 0.84
   5 ?    4.2   0.0     0.023        46       1      20 [.     785     804 ..     785     837 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.6
     Kelch_2  34 vldlekhvWe 43 
                  +++e+++W+
  EFC36264.1 311 EYNEEENEWS 320
                 69*******7 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 6.6
     Kelch_2  14 iyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 +++ GG     +++  s + ++  ++++W ++
  EFC36264.1 484 VFLSGGG---KSGRIYSQLVCYEVKEKKWVDM 512
                 5555555...5566667777888888888766 PP

  == domain 3  score: 18.2 bits;  conditional E-value: 8.8e-07
     Kelch_2   4 ghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44 
                  h+ +++g+ i+++GG  +  ++   +d+h +d  +++W e
  EFC36264.1 670 NHAQCTVGNSIFIFGGN-YTQKDNLLNDLHRYDIVSKKWNE 709
                 58889************.*********************86 PP

  == domain 4  score: 8.5 bits;  conditional E-value: 0.00099
     Kelch_2   3 gghsss.vpggkiyvvGGahtdnpnlsssdvhvldlekhvWeevtp 47 
                   hs + ++++ iy+ GG+    +n  s+ ++ +d + ++++  +p
  EFC36264.1 720 RNHSLCnCIDQYIYLTGGI--LRGNTISDVIYRFDVKNNEFAVINP 763
                 567777799**********..**************99888876665 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.023
     Kelch_2   1 rrgghsssvpggkiyvvGGa 20 
                 +r+ h++ + +g++y++GG 
  EFC36264.1 785 PRADHTTLYDQGQLYMIGGM 804
                 7899999999*********7 PP

>> LodA_N  L-Lysine epsilon oxidase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   2.2   1.3e-06    0.0026      61     190 ..     385     511 ..     358     513 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 1.3e-06
                 EE-TTSTTEEEEEEEE...EEEE-GGGSB---TTTGG-GGGSTTTT--BTTTT--SHHHHCTSEE---EEEESTTEEE---T-S--SEE---EEEEEEE CS
      LodA_N  61 eltldekevakieWtv...hlankKaawyefeealdipeaksaesesklrNadvtaadrkkLvidpgprsisgsskeeakfdkgsfpegkivsLGelrt 156
                 +++ ++k++++++W +   +l n+K + ++f+ + di+++k    ++     +v     ++ ++d +  +  +++++ + f+++ + ++ + sLG++  
  EFC36264.1 385 QVE-EKKSKENVNWDSvysKLENRKLNQMKFTMK-DIESHKLHYDKVDTSRFEV----TNSVAVDNSDDEDAQQRRKFKVFEQKVIKQSVDLSLGKMAG 477
                 333.678899999*74333899*****9999755.5666665333333333344....577899988887666664556666666666689******** PP

                 -TTS-EEEE-----EEE..SS-TTSTT--TTEEE CS
      LodA_N 157 dekgrLlvlgGsGksasldgkpltsfanndgWyD 190
                  ++g L++l+G Gks+ + ++ ++  +  ++W D
  EFC36264.1 478 SAHGSLVFLSGGGKSGRIYSQLVCYEVKEKKWVD 511
                 ******************9999999999999998 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.1      0.23   4.6e+02      43      99 ..      13      68 ..      11      70 .. 0.90
   2 ?   -2.1   0.0         2     4e+03      10      43 ..     972    1005 ..     971    1008 .. 0.84
   3 ?   -0.5   0.1      0.65   1.3e+03       2      28 ..    1077    1103 ..    1076    1105 .. 0.87
   4 ?   10.9   0.1   0.00019      0.38       6      43 ..    1113    1150 ..    1108    1151 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.23
        BACK 43 eqllellssdeLnvesEeevfeavlkWvkhdeeerkkhlpelLekvRlpllspeyLk 99
                ++l+ ++++ +L v++  e+f+ v  ++++  +++++  +  L+ + ++l++++ ++
  EFC36264.1 13 KDLIIVINKMDL-VDNSLELFDFVRIYIEKSFKQMQTFRKTTLKIIPMSLMNEKNIV 68
                678888999999.99999*********************************998775 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2
        BACK   10 aysceeLaeaakefilknfeevlkseeFleLske 43  
                  ++ c+ L++ +++++++ + e ++++++ +++ +
  EFC36264.1  972 KHDCSALYQNIEDTMDNFIREPCAENNYADVTIQ 1005
                  5899***********9999999999988887765 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.65
        BACK    2 lgilefAeaysceeLaeaakefilknf 28  
                  ++++  +  ++++eLa+++++++ +++
  EFC36264.1 1077 VEVFICSLLFQLNELANYCRTIVIQHI 1103
                  5678889999**************998 PP

  == domain 4  score: 10.9 bits;  conditional E-value: 0.00019
        BACK    6 efAeaysceeLaeaakefilknfeevlkseeFleLske 43  
                   + + y+   L++ + + i +nfee++k + F +Ls e
  EFC36264.1 1113 FLVDVYNDLALKNNCIKCISQNFEEISKRDGFENLSSE 1150
                  5668899999*************************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1002  (0.0558871); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.83u 0.31s 00:00:01.13 Elapsed: 00:00:00.51
# Mc/sec: 6972.36
//
Query:       EFC36265.1  [L=483]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-42  146.7   0.0    1.6e-42  146.4   0.0    1.0  1  DAO            FAD dependent oxidoreductase
     0.0021   18.3   0.4     0.0059   16.8   0.0    2.0  2  NAD_binding_8  NAD(P)-binding Rossmann-like domain
  ------ inclusion threshold ------
       0.02   15.2   0.4       0.11   12.8   0.1    2.2  2  YafQ_toxin     Bacterial toxin of type II toxin-antitoxin sys


Domain annotation for each model (and alignments):
>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  146.4   0.0   2.6e-46   1.6e-42       3     351 ..      38     472 ..      37     473 .. 0.77

  Alignments for each domain:
  == domain 1  score: 146.4 bits;  conditional E-value: 2.6e-46
                 EEECTSHHHHHHHHHHHHT.T.............EEEEESSSSTTSSGGGSSEEEEESSSSTHHSTHHHHHHHHHHHHHHHHHHHHHSSTTSEEEEEEE CS
         DAO   3 viiGGGiiGlstAyeLarr.g.............VtllekgdiagsgaSgrnsgllhsglrylpeaselarlslealeelreleeelgididyrrtGll 87 
                 ++iG+G++Gl++A  L+r+ +             ++++e+++++g ++S rns ++h+gl+y pe   + +l+ +++ +l++++ee +  i+yr+ G+ 
  EFC36265.1  38 LVIGSGVVGLAIAARLSREaNnsksssvsksdyqTLVVERNSFIGMETSARNSEVIHAGLYYEPES-LKTKLCIRGNSLLYDFCEEFN--IPYRNIGKF 133
                 69**************8754234566788899****************************966655.888***************988..89******* PP

                 EEES..SHHHHHHHHHHHHHH........HHTTT.TE.EEEEHHHHHHHSTTSTTTSEEEEETTEEEEEHHHHHHHHHHHHHHTT.-EEEESECEEEEE CS
         DAO  88 slaa..deeelealdkllall........leagl.da.elldaeevrelepalpgllgalfypdtgqvdpakltaalaraaealG.veilegtevtgle 173
                 ++a   ++++ e+l +++++          e g  +   ++++ee++e+ep++ +   al++ +tg+v+ a l+  l++ +++    +++++t+v ++ 
  EFC36265.1 134 IVANssNDHDVEYL-NSMKRKsnenfekyDERGRmKKlVFISKEELNEKEPNV-KSDVALYSQSTGIVCSATLMSRLLEMIQSSEnSTFINNTKVHNIY 230
                 **974433345555.4444434444544422332233247***********75.45789*********************9888747***********5 PP

                 EEE.TCEEEEE.....EECTEEEE....EEEEEEE--GGGHHHH.HTT.CTT........TSEEEEEEEEEEEEEECCTHSTGSGCSEEEEE...EEET CS
         DAO 174 eed.gkvwgve.....rttpgend....aadavVnaaGawsdll.gll.kel........dlpispvrgqvlvlkplseklvspaailpvpe...tddd 249
                 +++ +    ve     ++  g++d    +ad +Vn+aG+ s  + +l+  ++        +  ++ ++g+++ ++  ++    +++i+pvp        
  EFC36265.1 231 QYNnN--FLVElccigQH--GQIDrvnvIADNIVNSAGLDSERIaELAySDFtngmnlpeQYHLHYFKGHYFKYRASHQ---IKHLIYPVPPdskGLVH 322
                 54432..33434465422..322123336799******9999664555655565555554456677********66655...45577777766666777 PP

                 TTTEEEEEETTSEEEEEESSE...............................EETTCSSTSCSHHHHHHHHHHHHHHSGG..GCGEEEEEEEEEE.E.. CS
         DAO 250 grgvyvtprkdgrvlvGgtad...............................eesgdddpevdeedidellealrklfPq..lgdvlrkwaGlrp.l.. 312
                 g g++ t +++g++++G++                                 ++++ d   v+  + +++ +++++++ +  l+++   ++G+rp l  
  EFC36265.1 323 GLGTHSTLDLNGNLKFGPDSNyigkardlfpeqyskqmvgdanmdtlsyrlyPHYKID--NVNNVRGQAFFQSISNYMTGlsLENLHADYVGIRPkLqk 419
                 99999999**********9889999999999988888888888888887764444333..477779999*********9954588999*******7344 PP

                 T.TS..SEEEEEEE...........TEEEEEEEEECTTTHHHHHHHHHHHHHH CS
         DAO 313 p.dg..lpligetp...........gvkglylatGhsghGltlapatGkllae 351
                 p d+  +++i   +            +k ++ + G++++Glt+++a++ ++a+
  EFC36265.1 420 PgDKfrDFIIETLSdalpnnsktptLSKQFINLIGIESPGLTSSLAIANHVAN 472
                 434499999998448999******9999**********************996 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   9.9e-07    0.0059       1      35 [.      39      85 ..      39      99 .. 0.74
   2 ?   -3.2   0.1       1.7     1e+04      43      57 ..     284     297 ..     274     303 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 9.9e-07
                   EE--SHHHHHHHHHHH............CCTEEEEEE-SSSSSSGGG CS
  NAD_binding_8  1 IvGaGlsGlvaAylLa............kagfdvlllekrdrlGGra 35
                   ++G+G+ Gl++A++L+            k +++ l++e+++ +G   
     EFC36265.1 39 VIGSGVVGLAIAARLSreannsksssvsKSDYQTLVVERNSFIGMET 85
                   8***************4444443333333489999999999998654 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.7
                    CEECTS---EEETTH CS
  NAD_binding_8  43 vrvdygahifhgsgy 57 
                     + +y  h+f+g +y
     EFC36265.1 284 LPEQYHLHYFKG-HY 297
                    566788999998.55 PP

>> YafQ_toxin  Bacterial toxin of type II toxin-antitoxin system, YafQ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.29   1.7e+03      67      86 ..     229     249 ..     227     251 .. 0.87
   2 ?   12.8   0.1   1.9e-05      0.11      33      86 ..     278     330 ..     261     331 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.29
                 EEEE-SS.EEEEEEEE-HHHH CS
  YafQ_toxin  67 iYrledd.elvlvrlGsHsel 86 
                 iY+++++  + l+ +G+H ++
  EFC36265.1 229 IYQYNNNfLVELCCIGQHGQI 249
                 9*99999778899*****876 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.9e-05
                 HHTT-S--GGG--EE-SSS-TTEEEEE.EETTEEEEEEE-SSEEEEE.EEE-HHHH CS
  YafQ_toxin  33 LaegepLpekyrdHaLkgnwkgyrecH.ikpDllLiYrleddelvlv.rlGsHsel 86 
                   +g +Lpe+y+ H  kg++ +yr  H ik+   LiY +  d   lv  lG+Hs l
  EFC36265.1 278 FTNGMNLPEQYHLHYFKGHYFKYRASHqIKH---LIYPVPPDSKGLVhGLGTHSTL 330
                 567889*********************4555...9**999997777769****988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.43u 0.25s 00:00:00.68 Elapsed: 00:00:00.38
# Mc/sec: 3782.16
//
Query:       EFC36266.1  [L=2426]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.1e-25   88.5   0.0    9.3e-25   87.3   0.0    1.6  1  Guanylate_cyc    Adenylate and Guanylate cyclase catalytic do
      2e-10   40.8   0.4    1.1e-09   38.5   0.0    2.6  2  PAS_9            PAS domain
    6.5e-06   26.1   0.0    1.8e-05   24.7   0.0    1.8  1  PAS              PAS fold
     0.0022   18.2   0.0     0.0053   17.0   0.0    1.7  1  PAS_4            PAS fold
  ------ inclusion threshold ------
      0.025   14.0   0.3      0.025   14.0   0.3    2.2  2  HNOBA            Heme NO binding associated
      0.064   13.0   0.0       0.24   11.2   0.0    2.0  2  CUE              CUE domain
      0.079   12.4   0.0        7.8    5.9   0.0    2.5  2  Peptidase_S9     Prolyl oligopeptidase family
      0.088   12.7   0.3       0.46   10.4   0.0    2.4  2  BAAT_C           BAAT / Acyl-CoA thioester hydrolase C termin
       0.37   11.3   6.5      0.044   14.3   0.7    2.5  2  TFIIS_M          Transcription factor S-II (TFIIS), central d


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.3   0.0   4.6e-28   9.3e-25       4     135 ..    1358    1493 ..    1355    1506 .. 0.90

  Alignments for each domain:
  == domain 1  score: 87.3 bits;  conditional E-value: 4.6e-28
  Guanylate_cyc    4 esydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp...eekaahaaklaelaLdmlealeevav 94  
                      ++d+vt +F+dIvg  +l    s+ ++v+ Ln+l+ +fde + + +++k+kti ++y ++ gl+    ++++h  +++e+aL+++e  + ++ 
     EFC36266.1 1358 DKFDHVTCIFSDIVGLLDLGL--SATDLVQNLNDLVMQFDEACVRFNLEKIKTIQSKYFCTGGLKaneMKDEEHELRVFEFALNLFEIFNDFQL 1449
                     689************999977..679***************************************88877889999***********9988776 PP

  Guanylate_cyc   95 es...keglkvrvGihtGpvvagviGakkprydvwGntvnlAsr 135 
                     ++   + ++ +r Gi+ Gp vagv G  k  yd+wG++vn As 
     EFC36266.1 1450 RNehrNWNIGLRAGINAGPLVAGVCGVLKYAYDIWGDAVNAASL 1493
                     55434789**********************************95 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.5   0.0   5.5e-13   1.1e-09       5     104 .]    1218    1317 ..    1215    1317 .. 0.95
   2 ?   -2.9   0.1         4     8e+03      15      30 ..    1549    1564 ..    1543    1577 .. 0.83

  Alignments for each domain:
  == domain 1  score: 38.5 bits;  conditional E-value: 5.5e-13
       PAS_9    5 lidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk....kerevevvlirkngetfwvlltaspvkdddgelvgiiv 97  
                  +++  +g+i  +N+a ++l+G+ +++++g ++  lf  d++++  l+ ++ q++       ++ e+v +rkn  t+ v+++++    d+++++   +
  EFC36266.1 1218 IVCSANGTIDIFNNASEKLFGFRSDQMIGFPLVKLF--DKSSEASLQPIITQMSMassgYSETLELVGVRKNLATVSVEMRICVSVTDSRNVIT--C 1310
                  34779*******************************..*********************99************************9********..* PP

       PAS_9   98 ilrDite 104 
                  ++rD+te
  EFC36266.1 1311 FIRDLTE 1317
                  ******8 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 4
       PAS_9   15 yaNeaalrllGyspee 30  
                   +N+a+l+ +G+ +++
  EFC36266.1 1549 AMNYAFLNTMGFPKKD 1564
                  58*********99887 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.7   0.0   8.9e-09   1.8e-05       4     112 ..    1207    1314 ..    1206    1315 .. 0.82

  Alignments for each domain:
  == domain 1  score: 24.7 bits;  conditional E-value: 8.9e-09
                  HHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC..TTSSEEEEEEEEEEEEE CS
         PAS    4 raileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl..rdgrpihlevraspvrd 98  
                  raile++ +  +v  ++g i  +N a e+l+G++ ++++g +l+ l+   ++a l+ +++q   +++  +     +    ++  ++ +e+r +  + 
  EFC36266.1 1207 RAILEAALTSAIVCSANGTIDIFNNASEKLFGFRSDQMIGFPLVKLFDKSSEASLQPIITQMSMASSGYSE-TLELVGvrKNLATVSVEMRICVSVT 1302
                  799***999999999********************************988777555555555554444444.4444445889999999999999999 PP

                  TTEEEEEEEEEEEE CS
         PAS   99 aggeilgflgvlrd 112 
                   + +   + +++rd
  EFC36266.1 1303 DSRN--VITCFIRD 1314
                  9999..9******9 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   2.7e-06    0.0053       8     107 ..    1217    1317 ..    1210    1319 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 2.7e-06
       PAS_4    8 lavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvlegeepiefleelll...pgeerhyelrl.lPlrdesGevigvlv 100 
                   +v++++g++   N+a+++lfg++ ++++G +l  l+ +++ a l+++++++      ++++ el+    + +++ +e+r+ + + d++     + +
  EFC36266.1 1217 AIVCSANGTIDIFNNASEKLFGFRSDQMIGFPLVKLFDKSSEASLQPIITQMSMASSGYSETLELVGvrkNLATVSVEMRIcVSVTDSRN---VITC 1310
                  6899************************************99999999999988888888888888887999999999998888877433...4777 PP

       PAS_4  101 isrDiTe 107 
                  ++rD+Te
  EFC36266.1 1311 FIRDLTE 1317
                  7788877 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.3   1.3e-05     0.025     189     221 .]    1316    1348 ..    1310    1348 .. 0.92
   2 ?   -1.8   0.2      0.89   1.8e+03     183     211 ..    2059    2087 ..    2049    2136 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.3e-05
       HNOBA  189 aeLeesmkeleeekkrtdeLLysmiPkevAerL 221 
                  +e++ + kel e+kk++++LL +++P +vA+rL
  EFC36266.1 1316 TEIKMQVKELAEQKKKSEALLMNIMPYSVAKRL 1348
                  6788899************************98 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.89
       HNOBA  183 qleeksaeLeesmkeleeekkrtdeLLys 211 
                  +++  s++++++ + ++ ekk td+L  +
  EFC36266.1 2059 NVNVLSDRIKRMKEMIDMEKKETDRLTKQ 2087
                  66677888888888888888888888655 PP

>> CUE  CUE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.9   3.8e+03      21      31 ..     314     324 ..     311     324 .. 0.87
   2 ?   11.2   0.0   0.00012      0.24       3      41 ..    1969    2007 ..    1967    2008 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.9
                 HHHHHHCTTTH CS
         CUE  21 ravLrasngnv 31 
                 ++vLr+s+++v
  EFC36266.1 314 TYVLRRSTNSV 324
                 79*******98 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00012
                  HHHHHHHHHSTTS-HHHHHHHHHHCTTTHHHHHHHHHHC CS
         CUE    3 qmletLkemFPdldeevIravLrasngnvEatinaLLeg 41  
                  +++ +Lk++ Pd     Ir++L++ +g+ Ea+++ LL g
  EFC36266.1 1969 EKVRSLKQLLPDKKTKEIRDALIRCKGREEAAMEGLLTG 2007
                  6899*****************************988876 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0    0.0039       7.8      47      80 ..    1646    1679 ..    1634    1687 .. 0.86
   2 ?    3.5   0.0     0.021        41     144     188 ..    1810    1854 ..    1787    1867 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0039
                    HHHHHHHHHHHTTS--GGGEEEEEETHHHHHHHH CS
  Peptidase_S9   47 DfiaaaealakegyvdserlaitGgSyGGyltga 80  
                    D + ++e+l ++  v++++l+i G+S G  +++ 
    EFC36266.1 1646 DAVSGLEYLSTRPDVNPSKLGILGHSEGVNVVLK 1679
                    8899***********************9777765 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.021
                    -EEEEEEETT-SSS-THHHHHHHHHHH--S-S.EEEEEETTS-SST CS
  Peptidase_S9  144 pplLlihGlaDdrvppaealklvaaLqkkgkn.vlllifpdegHgv 188 
                    p ++ + + +D +v+p+    l++ L +++   +  +++p+  H +
    EFC36266.1 1810 PFVCALNSPTDANVHPEDYKNLIDVLSQRDARlTFSQVYPNLTH-F 1854
                    4566778889*********************99999*******9.4 PP

>> BAAT_C  BAAT / Acyl-CoA thioester hydrolase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       2.7   5.5e+03      47      94 ..      11      59 ..       7      80 .. 0.58
   2 ?   10.4   0.0   0.00023      0.46       9      39 ..    1650    1680 ..    1648    1757 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.7
                EEEEEES--SB--SSEEEETTE...EE----B-GGG-EE-TTS-EE-TT CS
      BAAT_C 47 savvlingsavvvegklvykdes.kvlpelklsmeklkvnknglldivd 94
                sa+vli ++++++  +     +s  +  ++++ ++++k++k+++ ++  
  EFC36266.1 11 SAAVLIIPTHTNHHLNVTTSPKSpTPSSNVPFLAQNSKKQKSQASVRSL 59
                6899999999999777777766554444444444444444443333332 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00023
                  HHHHHHCSTTB--SSEEEEEETHHHHHHHHH CS
      BAAT_C    9 ainyllrhpkvkkdkigllGiSkGgelalll 39  
                  +++yl+ +p v+ +k g+lG+S G +++l  
  EFC36266.1 1650 GLEYLSTRPDVNPSKLGILGHSEGVNVVLKS 1680
                  689***********************99843 PP

>> TFIIS_M  Transcription factor S-II (TFIIS), central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.6       6.1   1.2e+04      86     100 ..    1319    1333 ..    1316    1334 .. 0.85
   2 ?   14.3   0.7   2.2e-05     0.044      11      75 ..    1918    1991 ..    1912    1995 .. 0.63

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 6.1
                  ---TTTSS-HHHHHH CS
     TFIIS_M   86 kmspeElaseelkee 100 
                  km+ +Ela++++k+e
  EFC36266.1 1319 KMQVKELAEQKKKSE 1333
                  899999999999876 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 2.2e-05
                  HHHHTT---...-....--THHHHHHHHHHHHHH......HT------HHHHHHHHHHHHHS-TT-HHHHHTSS CS
     TFIIS_M   11 Laealeedsseaee...eedveelaaeiEealfe......kekkstdkkykqkvrslvfNLkdkkNpeLrrrvl 75  
                  L + l ++s e e+      v++    +E+++         ++++  k yk+kvrsl++ L dkk++e+r+ ++
  EFC36266.1 1918 LSTRLLNESVERENekrGHFVKKKTILVEREIEIieedeeGYIQQHVKGYKEKVRSLKQLLPDKKTKEIRDALI 1991
                  4444444443333322234777777777777533335444333344455*********************9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2426 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1393  (0.0776954); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 1.28u 0.35s 00:00:01.63 Elapsed: 00:00:00.55
# Mc/sec: 13268.64
//
Query:       EFC36267.1  [L=335]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.6e-31  106.7  66.0    1.7e-06   27.7   5.4    6.4  9  LRR_8     Leucine rich repeat
    5.4e-31  104.0  53.1    0.00043   20.1   0.3   12.4 13  LRR_6     Leucine Rich repeat
      3e-20   72.0  46.2    0.00013   22.3   6.8    8.3 11  LRR_4     Leucine Rich repeats (2 copies)
    1.8e-06   27.6  14.3      0.036   13.6   0.1    4.3  4  LRR_9     Leucine-rich repeat
    5.6e-05   23.1  33.4       0.92   10.3   0.0   10.7 10  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
        2.2    8.3   5.3       0.69    9.9   0.2    3.1  3  LRR_3     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   1.4   2.6e-05     0.076       2      56 ..      17      71 ..      16      76 .. 0.92
   2 !   24.9   1.8   4.1e-09   1.2e-05       1      61 []      40     100 ..      40     100 .. 0.99
   3 !   25.7   0.1   2.3e-09     7e-06       4      61 .]      67     124 ..      64     124 .. 0.90
   4 !   27.7   5.4   5.6e-10   1.7e-06       2      56 ..      89     143 ..      88     143 .. 0.98
   5 !   27.6   8.2   6.2e-10   1.8e-06       2      61 .]     113     169 ..     112     169 .. 0.97
   6 !   21.4   0.3   5.1e-08   0.00015       2      58 ..     182     238 ..     181     241 .. 0.95
   7 !   23.5   0.6   1.2e-08   3.6e-05       2      60 ..     230     288 ..     229     289 .. 0.90
   8 !   24.9   2.1   4.1e-09   1.2e-05       2      61 .]     254     313 ..     253     313 .. 0.98
   9 !   15.9   1.4   2.7e-06    0.0082       2      39 ..     278     315 ..     277     333 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.6e-05
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56
                +Lt+L ++++ lt  + +   +lsnL+ L++++ ++  l  + +s+L+++++L  
  EFC36267.1 17 KLTELCINSSELTPQSAHLIAKLSNLTNLSINRCSIADLGTNNISQLKQIKYLRA 71
                899************************************************9975 PP

  == domain 2  score: 24.9 bits;  conditional E-value: 4.1e-09
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nLt+L++++ ++ +l+    ++l++ k+L   +N + ++ ++ +  +++L+ L LsgNr+
  EFC36267.1  40 SNLTNLSINRCSIADLGTNNISQLKQIKYLRACENGIGSIGARNIGEMKNLTLLELSGNRI 100
                 69*********************************************************98 PP

  == domain 3  score: 25.7 bits;  conditional E-value: 2.3e-09
                 SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   4 tsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++L  + N + s++      ++nL+ L+Ls N++     +++  L++L +LdL  N +
  EFC36267.1  67 KYLRACENGIGSIGARNIGEMKNLTLLELSGNRIGDDGLESIGKLSKLAYLDLGENEI 124
                 566668899********************************************99976 PP

  == domain 4  score: 27.7 bits;  conditional E-value: 5.6e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 nLt L Ls Nr+ + + e+  +ls+L +LdL++N++t    +++ +L++L  L+L
  EFC36267.1  89 NLTLLELSGNRIGDDGLESIGKLSKLAYLDLGENEITDQGLKSLNNLEKLVTLNL 143
                 9****************************************************98 PP

  == domain 5  score: 27.6 bits;  conditional E-value: 6.2e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L +LdL  N +t+ + ++ ++l++L +L+L+nN++t l+  ++s+L +L+ Ld++ N++
  EFC36267.1 113 KLAYLDLGENEITDQGLKSLNNLEKLVTLNLKNNKITNLE--TISHL-KLTNLDVTTNKI 169
                 899************************************6..*****.*********997 PP

  == domain 6  score: 21.4 bits;  conditional E-value: 5.1e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +L++L +++N++ts + +  +g+++L+ + L +Nl+    + ++  L +L++LdL g
  EFC36267.1 182 RLKVLRINDNHITSDGAKILSGMTQLTCIFLCDNLIGDEGALSIGLLYNLEYLDLKG 238
                 79************************************9999999*********986 PP

  == domain 7  score: 23.5 bits;  conditional E-value: 1.2e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 nL++LdL    +t+ + ++   l nL+ L+ s+N+++ l ++ +sg+++L+ L++ +++
  EFC36267.1 230 NLEYLDLKGAGITGEGLKTICELINLRRLHVSHNQISDLGAKYISGMNNLTALNVCDCN 288
                 79999999999999999999999******************************987666 PP

  == domain 8  score: 24.9 bits;  conditional E-value: 4.1e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nL++L++s+N++++l+ +  +g++nL+ L+  + ++ +  ++ +s++ sL  Ld++ N+L
  EFC36267.1 254 NLRRLHVSHNQISDLGAKYISGMNNLTALNVCDCNIGFEGAQFISNMQSLADLDITKNNL 313
                 8*********************************************************98 PP

  == domain 9  score: 15.9 bits;  conditional E-value: 2.7e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt 39 
                 nLt L++++ ++   + ++ +++++L  Ld++ N+ltt
  EFC36267.1 278 NLTALNVCDCNIGFEGAQFISNMQSLADLDITKNNLTT 315
                 8***********************************98 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1       0.9   2.7e+03       2      18 ..      15      31 ..      14      37 .. 0.75
   2 ?    4.2   0.4     0.018        54       2      19 ..      39      56 ..      38      56 .. 0.89
   3 ?   -2.2   0.3       2.1   6.2e+03      13      23 ..      74      84 ..      73      85 .. 0.82
   4 !   20.1   0.3   1.5e-07   0.00043       4      23 ..      89     108 ..      86     109 .. 0.92
   5 !   16.9   0.1   1.5e-06    0.0045       3      23 ..     112     132 ..     110     132 .. 0.92
   6 !    6.3   1.4    0.0038        11       4      17 ..     137     150 ..     134     151 .. 0.89
   7 !   18.1   0.1   6.5e-07    0.0019       3      24 .]     157     178 ..     155     178 .. 0.92
   8 !   11.2   0.0   0.00011      0.31       4      21 ..     182     199 ..     180     202 .. 0.91
   9 !    7.3   0.1    0.0018       5.4      12      23 ..     214     225 ..     205     226 .. 0.87
  10 !   15.7   0.1   3.9e-06     0.012       4      24 .]     230     250 ..     228     250 .. 0.95
  11 !   19.1   0.0     3e-07    0.0009       4      24 .]     254     274 ..     251     274 .. 0.91
  12 !    9.4   0.1   0.00039       1.2       3      23 ..     277     297 ..     275     298 .. 0.90
  13 !    7.9   0.4    0.0012       3.5       3      21 ..     301     319 ..     299     320 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.9
       LRR_6  2 nthLteLdLsgNdIgDe 18
                +++LteL +++ +++ +
  EFC36267.1 15 HSKLTELCINSSELTPQ 31
                789***98888777765 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.018
       LRR_6  2 nthLteLdLsgNdIgDeG 19
                 ++Lt L+++ + I D G
  EFC36267.1 39 LSNLTNLSINRCSIADLG 56
                589***********9976 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 2.1
       LRR_6 13 NdIgDeGaeaL 23
                N+Ig  Ga  +
  EFC36267.1 74 NGIGSIGARNI 84
                99**9999765 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 1.5e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt L+LsgN IgD+G+e++
  EFC36267.1  89 NLTLLELSGNRIGDDGLESI 108
                 8999**************98 PP

  == domain 5  score: 16.9 bits;  conditional E-value: 1.5e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++L +LdL  N+I+D+G+++L
  EFC36267.1 112 SKLAYLDLGENEITDQGLKSL 132
                 7899***************97 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.0038
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +L +L+L+ N+I++
  EFC36267.1 137 KLVTLNLKNNKITN 150
                 799*********96 PP

  == domain 7  score: 18.1 bits;  conditional E-value: 6.5e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt Ld++ N+Ig+eGa+ +a
  EFC36267.1 157 LKLTNLDVTTNKIGNEGAKYIA 178
                 68*****************987 PP

  == domain 8  score: 11.2 bits;  conditional E-value: 0.00011
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                  L+ L +++N+I+ +Ga+
  EFC36267.1 182 RLKVLRINDNHITSDGAK 199
                 59**************97 PP

  == domain 9  score: 7.3 bits;  conditional E-value: 0.0018
       LRR_6  12 gNdIgDeGaeaL 23 
                 +N IgDeGa ++
  EFC36267.1 214 DNLIGDEGALSI 225
                 799******998 PP

  == domain 10  score: 15.7 bits;  conditional E-value: 3.9e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L++LdL+g +I++eG++ ++
  EFC36267.1 230 NLEYLDLKGAGITGEGLKTIC 250
                 79****************998 PP

  == domain 11  score: 19.1 bits;  conditional E-value: 3e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L+ L++s+N+I+D Ga+ ++
  EFC36267.1 254 NLRRLHVSHNQISDLGAKYIS 274
                 8****************9875 PP

  == domain 12  score: 9.4 bits;  conditional E-value: 0.00039
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt+L++ +++Ig eGa+ +
  EFC36267.1 277 NNLTALNVCDCNIGFEGAQFI 297
                 79***************9876 PP

  == domain 13  score: 7.9 bits;  conditional E-value: 0.0012
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 ++L  Ld++ N+++  G++
  EFC36267.1 301 QSLADLDITKNNLTTNGIK 319
                 78999************87 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.3      0.16   4.7e+02      11      31 ..       4      24 ..       3      32 .. 0.64
   2 !    8.3   3.5    0.0011       3.1       2      42 ..      17      55 ..      16      65 .. 0.78
   3 !   16.8   0.0   2.2e-06    0.0066       3      38 ..      66     102 ..      64     111 .. 0.83
   4 !   22.3   6.8   4.3e-08   0.00013       2      43 ..     113     155 ..     112     156 .. 0.91
   5 !   13.2   4.9   3.1e-05     0.094       2      37 ..     137     170 ..     137     174 .. 0.84
   6 !    9.4   0.6   0.00049       1.5       2      37 ..     158     194 ..     157     202 .. 0.73
   7 !   16.9   0.2   2.1e-06    0.0064       1      38 [.     181     219 ..     181     224 .. 0.83
   8 !   11.8   0.2   8.3e-05      0.25       1      32 [.     205     238 ..     205     247 .. 0.89
   9 !   21.7   0.3   6.6e-08    0.0002       2      34 ..     254     288 ..     253     292 .. 0.88
  10 !    6.7   2.7    0.0035        11       2      36 ..     278     314 ..     277     319 .. 0.82
  11 ?    2.2   0.5      0.09   2.7e+02       3      29 ..     303     334 ..     301     335 .] 0.66

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.16
                S---E-S-HHH-TT--EEE-. CS
       LRR_4 11 NqltdiplleklpnLkeLdLs 31
                ++l +i+ +++  +L+eL ++
  EFC36267.1  4 CNLETINEISNHSKLTELCIN 24
                566777776666777777663 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0011
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGG CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeL 42
                +L++L++++  lt  +   ++kl nL+ L+++++    ++ +L
  EFC36267.1 17 KLTELCINSSELTPQSAhlIAKLSNLTNLSINRC----SIADL 55
                8999999987999766675558*********999....44433 PP

  == domain 3  score: 16.8 bits;  conditional E-value: 2.2e-06
                 --EEE--SS---E-S-HH.H.-TT--EEE-.-S----- CS
       LRR_4   3 LevLdLsnNqltdiplle.k.lpnLkeLdLsgNnlitd 38 
                  ++L    N + +i+  + + ++nL+ L LsgN +i+d
  EFC36267.1  66 IKYLRACENGIGSIGARNiGeMKNLTLLELSGN-RIGD 102
                 688999999*******66644************.7765 PP

  == domain 4  score: 22.3 bits;  conditional E-value: 4.3e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeLk 43 
                 +L +LdL+ N +td +l  l++l +L +L+L  Nn+it+l++++
  EFC36267.1 113 KLAYLDLGENEITDQGLksLNNLEKLVTLNL-KNNKITNLETIS 155
                 6779**********99999999*********.999*****9876 PP

  == domain 5  score: 13.2 bits;  conditional E-value: 3.1e-05
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlit 37 
                 +L +L+L nN++t ++ ++   +L+ Ld++ N +i+
  EFC36267.1 137 KLVTLNLKNNKITNLETIS-HLKLTNLDVTTN-KIG 170
                 6899*************99.788999999555.664 PP

  == domain 6  score: 9.4 bits;  conditional E-value: 0.00049
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L++Ld   N++   +   ++ ++ Lk+L +++N  it
  EFC36267.1 158 KLTNLDVTTNKIGNEGAkyIAEMKRLKVLRINDN-HIT 194
                 6888888855888666676456999999999666.665 PP

  == domain 7  score: 16.9 bits;  conditional E-value: 2.1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L+vL +++N++t+ +   l+++++L+ + L +N li+d
  EFC36267.1 181 KRLKVLRINDNHITSDGAkiLSGMTQLTCIFLCDN-LIGD 219
                 68************744488889*********777.8877 PP

  == domain 8  score: 11.8 bits;  conditional E-value: 8.3e-05
                 SS--EEE--SS---E-S-HH.H.-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdiplle.k.lpnLkeLdLsg 32 
                 ++L+ + L +N + d + l+ + l nL++LdL g
  EFC36267.1 205 TQLTCIFLCDNLIGDEGALSiGlLYNLEYLDLKG 238
                 68999**********99988888*********54 PP

  == domain 9  score: 21.7 bits;  conditional E-value: 6.6e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 nL+ L+ s+Nq++d++   ++++ nL+ L++ ++n
  EFC36267.1 254 NLRRLHVSHNQISDLGAkyISGMNNLTALNVCDCN 288
                 9****************87668********87763 PP

  == domain 10  score: 6.7 bits;  conditional E-value: 0.0035
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 nL+ L+  ++++   +   ++++ +L  Ld++ Nnl 
  EFC36267.1 278 NLTALNVCDCNIGFEGAqfISNMQSLADLDITKNNLT 314
                 89*********99655574447*********999664 PP

  == domain 11  score: 2.2 bits;  conditional E-value: 0.09
                 --EEE--SS---E-S-..HH..H.-TT--EEE CS
       LRR_4   3 LevLdLsnNqltdipl..le..k.lpnLkeLd 29 
                 L  Ld+  N+lt+ +   ++  k  ++Lk+L 
  EFC36267.1 303 LADLDITKNNLTTNGIklCRnmKtSKKLKYLK 334
                 55689998999987777533564466677775 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.7   0.00044       1.3      51     125 ..       3      76 ..       1      83 [. 0.87
   2 !   10.4   1.4   0.00011      0.34      47     107 ..      93     155 ..      74     175 .. 0.53
   3 !   13.6   0.1   1.2e-05     0.036      62     119 ..     179     235 ..     160     245 .. 0.82
   4 ?    2.0   0.0     0.043   1.3e+02      87     125 ..     252     289 ..     236     315 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00044
       LRR_9  51 dndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 d ++  ++++    +l  l +n+  ++  +  l   l nl++l ++  ++ +l++ + + +lk++++l   +n +
  EFC36267.1   3 DCNLETINEISNHSKLTELCINSSELTPQSAHLIAKLSNLTNLSINRCSIADLGT-NNISQLKQIKYLRACENGI 76 
                 677778888888899999***********************************99.8999999999998777765 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00011
       LRR_9  47 idlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladld 107
                 ++ls n i +  l+++  l +l  l l +n i+  + +  + l +l +l l nn++++l ++ 
  EFC36267.1  93 LELSGNRIGDdgLESIGKLSKLAYLDLGENEITDQGLKSLNNLEKLVTLNLKNNKITNLETIS 155
                 344444443222455555555555555555555444444444455555555555555555544 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 1.2e-05
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklells 119
                  +krlk+l +n+n i+  + ++   + +l+++ l +n + + + l  +  l +le+l 
  EFC36267.1 179 EMKRLKVLRINDNHITSDGAKILSGMTQLTCIFLCDNLIGDEGALS-IGLLYNLEYLD 235
                 59*************************************9988753.55566666665 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.043
       LRR_9  87 lPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 l nl+ l +++n++ +l+  + +  +++l+ l + ++ +
  EFC36267.1 252 LINLRRLHVSHNQISDLGA-KYISGMNNLTALNVCDCNI 289
                 5577888888888888887.7788888888887777665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.2      0.69   2.1e+03       1      12 [.      17      28 ..       5      38 .. 0.69
   2 ?    3.7   0.8     0.047   1.4e+02       1      21 [.      41      61 ..      41      63 .. 0.83
   3 !    6.2   0.1    0.0067        20       1      23 []      89     111 ..      89     111 .. 0.87
   4 ?    2.5   0.1      0.11   3.4e+02       1      23 []     113     135 ..     113     135 .. 0.82
   5 ?    3.2   0.9     0.065     2e+02       1      15 [.     137     151 ..     137     178 .. 0.86
   6 ?    4.2   0.1     0.031        93       1      18 [.     182     199 ..     182     219 .. 0.84
   7 ?    2.7   0.0     0.098   2.9e+02       1      19 [.     230     248 ..     230     252 .. 0.71
   8 !   10.3   0.0   0.00031      0.92       1      22 [.     254     275 ..     254     276 .. 0.90
   9 ?    4.4   0.0     0.027        81       1      15 [.     278     292 ..     278     300 .. 0.72
  10 ?   -0.1   0.1      0.79   2.4e+03       5      13 ..     306     314 ..     302     324 .. 0.74

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.69
       LRR_1  1 nLrhLdLsnnpl 12
                +L++L +++  l
  EFC36267.1 17 KLTELCINSSEL 28
                577777776665 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.047
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                nL+ L ++++++ +l+ n ++
  EFC36267.1 41 NLTNLSINRCSIADLGTNNIS 61
                899********9888877766 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0067
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ L Ls+n++++ + +s+ +L
  EFC36267.1  89 NLTLLELSGNRIGDDGLESIGKL 111
                 89**********98888888765 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L +LdL+ n +++ +  s+ nL
  EFC36267.1 113 KLAYLDLGENEITDQGLKSLNNL 135
                 6789*******998888887765 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.065
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L +L+L nn +++l
  EFC36267.1 137 KLVTLNLKNNKITNL 151
                 6899******98654 PP

  == domain 6  score: 4.2 bits;  conditional E-value: 0.031
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L +++n++++ ++ 
  EFC36267.1 182 RLKVLRINDNHITSDGAK 199
                 69*********9765554 PP

  == domain 7  score: 2.7 bits;  conditional E-value: 0.098
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL++LdL +  ++g +  +
  EFC36267.1 230 NLEYLDLKGAGITGEGLKT 248
                 8******876666665555 PP

  == domain 8  score: 10.3 bits;  conditional E-value: 0.00031
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nLr+L++s+n++++l++ ++++
  EFC36267.1 254 NLRRLHVSHNQISDLGAKYISG 275
                 8*************99988875 PP

  == domain 9  score: 4.4 bits;  conditional E-value: 0.027
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL+ L++++++++  
  EFC36267.1 278 NLTALNVCDCNIGFE 292
                 89*********9433 PP

  == domain 10  score: -0.1 bits;  conditional E-value: 0.79
       LRR_1   5 LdLsnnpll 13 
                 Ld++ n+l+
  EFC36267.1 306 LDITKNNLT 314
                 99****995 PP

>> LRR_3  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1       1.2   3.5e+03       9      15 ..      15      21 ..      15      21 .. 0.86
   2 ?    9.9   0.2   0.00023      0.69       1      16 [.     137     152 ..     137     153 .. 0.92
   3 ?   -3.0   0.1       2.7   8.1e+03       4      12 ..     257     265 ..     254     265 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.2
       LRR_3  9 ySkLeKL 15
                +SkL+ L
  EFC36267.1 15 HSKLTEL 21
                8***987 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00023
       LRR_3   1 nLVeLnmpySkLeKLW 16 
                 +LV Ln+ ++k++ L 
  EFC36267.1 137 KLVTLNLKNNKITNLE 152
                 6************996 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 2.7
       LRR_3   4 eLnmpySkL 12 
                 +L++ ++++
  EFC36267.1 257 RLHVSHNQI 265
                 799999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1975.60
//
Query:       EFC36268.1  [L=700]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.025   14.8   1.2        4.6    7.4   0.0    3.6  3  DUF4809   Domain of unknown function (DUF4809)


Domain annotation for each model (and alignments):
>> DUF4809  Domain of unknown function (DUF4809)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0    0.0067   1.2e+02      76     122 ..     100     146 ..      81     152 .. 0.77
   2 ?    0.3   0.1     0.042   7.6e+02      59     101 ..     175     215 ..     166     226 .. 0.73
   3 ?    7.4   0.0   0.00026       4.6      37      63 ..     601     627 ..     586     645 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.0067
     DUF4809  76 ekevkfkeesanvtf.kskdqkiqvkkkledlqelfeevnqiLqqlFe 122
                 e ++ f+  + ++   +++++ + vk+ +++  + + +v++iL  + e
  EFC36268.1 100 ECNIYFHTRNGRIFMmDTREKVLDVKNTVSE-LHCYSKVKKILDSIIE 146
                 5567777777766541566777899999999.99*********99876 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.042
     DUF4809  59 qelllemleEvlifkkeekevkfkeesanvtfkskdqkiqvkk 101
                   l ++   E+ +f+ ee+ + ++++++ + f    + +  k 
  EFC36268.1 175 LILTYDG--EMKLFRYEEEIICLQNQEKIDDFVVSTNSVLLKT 215
                 4445554..9999999999999999999888888877776654 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.00026
     DUF4809  37 isleeLtvasLvdslalkegfkqelll 63 
                 +s+e+ t+++Lv+ ++ + +f+ e l+
  EFC36268.1 601 MSMENFTITELVSVIITAHHFQMEKLF 627
                 589*******************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (700 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       772  (0.0430587); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.28s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 4418.70
//
Query:       EFC36269.1  [L=696]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    6.8e-06   26.7   0.8    4.7e-05   24.0   0.7    2.4  1  RNase_T    Exonuclease
    0.00057   20.1   0.1     0.0019   18.4   0.1    1.9  1  zf-Di19    Drought induced 19 protein (Di19), zinc-binding
  ------ inclusion threshold ------
      0.016   15.2   0.3       0.04   13.9   0.1    1.9  2  DUF5051    3' exoribonuclease, RNase T-like
      0.032   15.1   0.1      0.032   15.1   0.1    3.3  3  zf-C2H2_4  C2H2-type zinc finger
       0.33   11.5   0.1       0.33   11.5   0.1    3.1  3  zf-C2H2    Zinc finger, C2H2 type


Domain annotation for each model (and alignments):
>> RNase_T  Exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.7   1.3e-08   4.7e-05      61     164 ..     534     645 ..     521     646 .. 0.86

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 1.3e-08
                 HHHHHTCEBHHHHHHHHHHHHHHHTCCCETTTCEEEESSHHHH..HHHHHHHHH.......HHHHCSEHCECHHHHHHHHHC.HHHHHHHHHTTCHSSS CS
     RNase_T  61 qemldeapsfkevleefkellrklallvahnaafdvgflraad..krilkkevp.......krnqfldtlildkatlkelar.tsldklaeklgleedg 149
                  + l++  ++ e+++ + ++l k++l+ ahna fd ++l +a+  +ri +   +        r  fldt+ ++k+tlk  ++  +l ++ ++l ++ + 
  EFC36269.1 534 TDCLQNGTKEMEAVKLIIDFLPKKSLILAHNAPFDKSVLHRAFnhWRINNS--KitdgmknSRLIFLDTIPILKKTLKLGKNqCKLGNIYQQLFKQSIE 630
                 44489999999*************************999998833555444..4559*9999999*****************9**************** PP

                 STSSHHHHHHHHHHH CS
     RNase_T 150 raHrAldDaeatakl 164
                 ++H+A +D+ a+ ++
  EFC36269.1 631 NQHTAAADVFALKEI 645
                 ********9988776 PP

>> zf-Di19  Drought induced 19 protein (Di19), zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.1   5.4e-07    0.0019      28      53 ..     363     390 ..     361     391 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 5.4e-07
     zf-Di19  28 eskevvCPvCaek..vtkdlvaHltleh 53 
                 ++ + vCP+C+++  v+k+l +Hl+++h
  EFC36269.1 363 KNDQIVCPLCQKNyaVGKNLLNHLRTKH 390
                 57899*****98767899********99 PP

>> DUF5051  3' exoribonuclease, RNase T-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       2.8     1e+04     115     143 ..      30      56 ..      21      66 .. 0.68
   2 ?   13.9   0.1   1.1e-05      0.04      74     163 ..     542     647 ..     525     650 .. 0.67

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 2.8
     DUF5051 115 kywndrdvrtlvalapelekgeekkreip 143
                   +++ +vrtl + +++  +++++ ++ip
  EFC36269.1  30 FLFQNYKVRTLTEEDED--GTQRHVYRIP 56 
                 45678889999998855..4445666665 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 1.1e-05
     DUF5051  74 slkdalqaleeFlekslkvwangasfDlviLraafel.....................lipwkywndrdvrtlvalapelekgeekkreipfe..gvkH 149
                 +  +a++ + +Fl k+  + a++a fD ++L  af+                      +ip         +tl+ ++ ++ k+ +  +++ ++  +++H
  EFC36269.1 542 KEMEAVKLIIDFLPKKSLILAHNAPFDKSVLHRAFNHwrinnskitdgmknsrlifldTIP------ILKKTLKLGK-NQCKLGNIYQQLFKQsiENQH 633
                 4557778899***99999****************998899888777766533322222111......1223444444.334444444444444789999 PP

     DUF5051 150 nALaDAkhqakavs 163
                  A aD  + +++++
  EFC36269.1 634 TAAADVFALKEILE 647
                 99999988888776 PP

>> zf-C2H2_4  C2H2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.3   1.7         5   1.8e+04       6      12 ..     206     212 ..     206     216 .. 0.51
   2 ?   15.1   0.1     9e-06     0.032       2      24 .]     368     390 ..     367     390 .. 0.95
   3 ?   -8.1   8.8         5   1.8e+04       3      19 ..     487     503 ..     486     507 .. 0.70

  Alignments for each domain:
  == domain 1  score: -5.3 bits;  conditional E-value: 5
   zf-C2H2_4   6 CgksFss 12 
                 C+ sF+ 
  EFC36269.1 206 CCNSFCG 212
                 5555533 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 9e-06
   zf-C2H2_4   2 kCpiCgksFsskkaLlrHlkthH 24 
                  Cp+C+k++   k+Ll+Hl+t H
  EFC36269.1 368 VCPLCQKNYAVGKNLLNHLRTKH 390
                 6********************99 PP

  == domain 3  score: -8.1 bits;  conditional E-value: 5
   zf-C2H2_4   3 CpiCgksFsskkaLlrH 19 
                 C+ C++ + ++ +  +H
  EFC36269.1 487 CKSCRQCCLNNGGCTTH 503
                 88887777777776767 PP

>> zf-C2H2  Zinc finger, C2H2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.5      0.77   2.8e+03      12      21 ..      10      19 ..       8      20 .. 0.85
   2 ?   -5.1   1.6         5   1.8e+04       3       9 ..     207     214 ..     206     215 .. 0.79
   3 ?   11.5   0.1   9.2e-05      0.33       2      23 .]     368     390 ..     367     390 .. 0.97

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.77
                SHHHHHHHHH CS
     zf-C2H2 12 rksnLkrHir 21
                ++  L++H+r
  EFC36269.1 10 QQKKLTHHQR 19
                6889*****9 PP

  == domain 2  score: -5.1 bits;  conditional E-value: 5
                 ET.TTTEE CS
     zf-C2H2   3 Cp.dCgks 9  
                 C+  Cg+s
  EFC36269.1 207 CNsFCGYS 214
                 77899987 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 9.2e-05
                 EETTTTEEESSHHHHHHHHHC.C CS
     zf-C2H2   2 kCpdCgksFkrksnLkrHirt.H 23 
                 +Cp C k +    nL +H+rt H
  EFC36269.1 368 VCPLCQKNYAVGKNLLNHLRTkH 390
                 7********************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (696 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1160  (0.0646996); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 4253.12
//
Query:       EFC36270.1  [L=279]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      9e-08   32.2 164.1      0.026   14.5  37.3    4.9  5  Trypan_PARP    Procyclic acidic repetitive protein (PARP)
  ------ inclusion threshold ------
        1.3    8.7  12.6        1.6    8.4  12.6    1.2  1  DUF966         Domain of unknown function (DUF966)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3  37.3   5.9e-05      0.53      59     111 ..       4      56 ..       1      58 [. 0.44
   2 !    5.5  46.6    0.0017        15      62     107 ..      53      98 ..      43     108 .. 0.27
   3 !   12.3  39.7   1.3e-05      0.12      59     113 ..     100     154 ..      96     157 .. 0.61
   4 !   14.5  37.3   2.9e-06     0.026      63     112 ..     156     205 ..     151     215 .. 0.49
   5 ?    0.4   0.2     0.068   6.1e+02      68      82 ..     234     246 ..     205     275 .. 0.31

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 5.9e-05
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  p+p+p+ +p+p+p+p+p p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC36270.1   4 PKPKPKSKPKPKPKPKPRPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 56 
                  34444444444444444444444444444444444444444444444444444 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0017
  Trypan_PARP  62 epepepepepepepepepetepeeepepepepepepepepepepep 107
                  +p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p
   EFC36270.1  53 KPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 98 
                  2222222222222222222222222222222222222222222222 PP

  == domain 3  score: 12.3 bits;  conditional E-value: 1.3e-05
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepepga 113
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p a
   EFC36270.1 100 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPTA 154
                  4555555555555555666666666666666666777777777777777777766 PP

  == domain 4  score: 14.5 bits;  conditional E-value: 2.9e-06
  Trypan_PARP  63 pepepepepepepepepetepeeepepepepepepepepepepepepepg 112
                   +p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p 
   EFC36270.1 156 ANPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPT 205
                  33444444444444444444444555555555555555555555555554 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.068
  Trypan_PARP  68 epepepepepepete 82 
                  +   + +++ + +t+
   EFC36270.1 234 Q--TQTQTQTQTQTQ 246
                  1..111111111111 PP

>> DUF966  Domain of unknown function (DUF966)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4  12.6   0.00017       1.6     146     235 ..     209     269 ..     128     278 .. 0.43

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00017
      DUF966 146 rkssssaeleeykvykaeeeeeaaeegaadastqtddkrrrsretkketasrgvstedeeeekeekestelsreeispppsssspsekss 235
                  +++++++++   + +++++++++++++++ +tqt+ +++++++                             +++  ++++++++++++
  EFC36270.1 209 TQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQ-----------------------------TQTQTQTQTQTQTQTQT 269
                 11111111111111111111111111111111111111111111.............................00000010111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3955  (0.220592); expected 358.6 (0.02)
Passed bias filter:                      664  (0.037035); expected 358.6 (0.02)
Passed Vit filter:                       310  (0.0172904); expected 17.9 (0.001)
Passed Fwd filter:                        92  (0.00513135); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.61u 0.41s 00:00:02.02 Elapsed: 00:00:00.59
# Mc/sec: 1432.32
//
Query:       EFC36271.1  [L=144]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (144 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.31s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 894.98
//
Query:       EFC36272.1  [L=186]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.022   14.5   0.3      0.022   14.5   0.3    1.8  2  PQ-loop   PQ loop repeat
       0.16   11.6   2.4       0.17   11.5   0.5    2.0  2  PIRT      Phosphoinositide-interacting protein family


Domain annotation for each model (and alignments):
>> PQ-loop  PQ loop repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.3       1.3   1.2e+04       7      15 ..       7      15 ..       4      18 .. 0.53
   2 ?   14.5   0.3   2.5e-06     0.022      23      46 ..     158     181 ..     157     186 .] 0.90

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 1.3
     PQ-loop  7 yislvlwlv 15
                +isl+l+++
  EFC36272.1  7 LISLALCVL 15
                455555554 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 2.5e-06
     PQ-loop  23 kNykrkSteGlSilflllwllGdi 46 
                 k+yk  S++GlS++++++ l++ +
  EFC36272.1 158 KIYKCGSASGLSVSMMVMLLVAIL 181
                 89*****************99865 PP

>> PIRT  Phosphoinositide-interacting protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1         1     9e+03      59      73 ..       5      19 ..       4      26 .. 0.60
   2 ?   11.5   0.5   1.9e-05      0.17      24      99 ..      82     176 ..      75     183 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 1
        PIRT 59 vfllGvvittlsrns 73
                +fl+ +++  ls + 
  EFC36272.1  5 LFLISLALCVLSVSC 19
                566666666665544 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 1.9e-05
        PIRT  24 tlcissrsesvwtngprskwdvykkpiivls..vGgavfllGvvittl.................srnstlknkdkevfklsGpaflslGlmllv 99 
                  ++is+  ++  +++++++++vyk  + + s  + g  +  G  i +                  s + ++  +dk+++k    + ls+ +m+++
  EFC36272.1  82 EIYISTFDDASCSATSKNRYEVYKTNVCIKSsvIFGPSYNSGKYIGCEkfilytddacktegstnSLTMNTCGTDKKIYKCGSASGLSVSMMVML 176
                 58999999999****************99874456777888888888788899999999999766666667778999999888888888887654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       632  (0.0352502); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.30s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1220.42
//
Query:       EFC36273.1  [L=439]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.6e-19   68.7   0.1    1.1e-18   67.5   0.0    1.6  2  CRAL_TRIO  CRAL/TRIO domain


Domain annotation for each model (and alignments):
>> CRAL_TRIO  CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0      0.66   1.2e+04       5      17 ..     189     201 ..     188     203 .. 0.81
   2 !   67.5   0.0   5.9e-23   1.1e-18      13     152 ..     246     400 ..     233     404 .. 0.85

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 0.66
   CRAL_TRIO   5 eggkvgihgrDke 17 
                 +g  ++++g+D +
  EFC36273.1 189 SGIYFYMRGWDPN 201
                 5778999***986 PP

  == domain 2  score: 67.5 bits;  conditional E-value: 5.9e-23
   CRAL_TRIO  13 grDkegrpvlylrlgrfdpk.kls.leel..vralvlvlerllkelee...............dgqvegvtvviDlkglslskmlwkpisllkkilkil 92 
                 g Dk+g+p++y+++gr d + kl+ +++l  +r+l+l++e +++ l +               +    ++t v+D+k++sls  l   ++ +k+i ++l
  EFC36273.1 246 GLDKMGNPMIYMVVGREDLSrKLDdRATLlrFRHLCLCFEYIMNRLYDgssqnylgqdksqflGSAPFQITWVVDIKDASLSIDL---VKKIKFIFDLL 341
                 67******************9666566551267889999999996666666666777777888778889***********77555...*********** PP

   CRAL_TRIO  93 qdnyperlgkilivnaPklfkfafklvkpfldektreKikfvspsnteatlekyidpeql 152
                   +yper   +++ n+P+++k+++ ++++fl ++ r+  +f+s+     +l++ id +++
  EFC36273.1 342 GFYYPERSEIVFVMNIPWMAKMLWAVISQFLTQRQRNQYQFLSDPFL-TKLSQNIDTKYV 400
                 ******************************************99998.7*******9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (439 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       493  (0.0274974); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 2862.51
//
Query:       EFC36274.1  [L=165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.8e-23   81.7   9.2    9.9e-12   45.1   1.6    3.0  3  EF-hand_7     EF-hand domain pair
    8.7e-23   78.1   4.3    3.6e-05   23.0   0.3    4.2  4  EF-hand_1     EF hand
    2.3e-20   70.7   3.3    0.00024   20.8   0.0    4.2  4  EF-hand_6     EF-hand domain
    9.6e-17   60.6   4.9    1.3e-05   24.9   0.0    3.5  4  EF-hand_8     EF-hand domain pair
    1.5e-15   55.8   1.7     0.0011   18.3   0.1    4.2  4  EF-hand_5     EF hand
    1.9e-07   30.8   1.2    0.00019   21.3   0.0    3.4  3  EF-hand_10    EF hand
      0.004   17.5   2.2        3.8    7.9   0.5    3.1  3  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
  ------ inclusion threshold ------
      0.026   14.5   1.9       0.17   11.9   0.5    2.3  2  EF-hand_4     Cytoskeletal-regulatory complex EF hand
      0.034   14.4   1.1      0.067   13.5   0.1    1.9  2  MecA_N        NTF2-like N-terminal transpeptidase domain
       0.08   12.8   2.8       0.34   10.8   0.1    2.2  2  IFN-gamma     Interferon gamma


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.1   1.6   5.5e-15   9.9e-12       2      69 ..      11      73 ..      10      75 .. 0.95
   2 !   19.3   0.0   6.2e-07    0.0011      46      71 .]     100     125 ..      79     125 .. 0.84
   3 !   33.6   0.2   2.2e-11     4e-08       8      70 ..     104     162 ..     103     163 .. 0.91

  Alignments for each domain:
  == domain 1  score: 45.1 bits;  conditional E-value: 5.5e-15
   EF-hand_7  2 eklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkl 69
                ++++  Fk++D+d++++++ +e+++l+ +     + g ++sd+ l ++   +D+d+dG+isfdEF ++
  EFC36274.1 11 SVIHSLFKKYDQDNSNSINISEMKNLFVA-----DMGINFSDDNLMAIQMYMDKDSDGKISFDEFFNY 73
                789**********************9999.....*******************************876 PP

  == domain 2  score: 19.3 bits;  conditional E-value: 6.2e-07
   EF-hand_7  46 lellfkefDtdkdGvisfdEFlklyr 71 
                   llfk+ Dt+++++is++EF+ +y+
  EFC36274.1 100 AALLFKNTDTSGNRQISREEFVSFYQ 125
                 6789********************97 PP

  == domain 3  score: 33.6 bits;  conditional E-value: 2.2e-11
   EF-hand_7   8 FkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkly 70 
                 Fk  Dt g+  +++ee+ +++++++       ++ d  +++ ++ +Dtdk+G++sf+E+ ++ 
  EFC36274.1 104 FKNTDTSGNRQISREEFVSFYQQLYN--NYSANMAD--IDYALNYIDTDKSGSLSFQELINWL 162
                 999********************976..67777777..*********************9986 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   2.6e-07   0.00047       2      26 ..      13      37 ..      12      39 .. 0.90
   2 !   23.0   0.3     2e-08   3.6e-05       9      28 ..      57      76 ..      55      77 .. 0.90
   3 !   13.4   0.0   2.4e-05     0.043       6      27 ..     104     125 ..     102     127 .. 0.89
   4 !   21.2   0.0   7.5e-08   0.00013       1      27 [.     137     163 ..     137     163 .. 0.92

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 2.6e-07
                HHHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1  2 lkeiFrefDkDgdGkIdfeEfkell 26
                +  +F+++D+D++  I+++E+k+l+
  EFC36274.1 13 IHSLFKKYDQDNSNSINISEMKNLF 37
                5679******************987 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 2e-08
                HTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1  9 fDkDgdGkIdfeEfkellkk 28
                +DkD dGkI+f+Ef +++++
  EFC36274.1 57 MDKDSDGKISFDEFFNYWTT 76
                8*************999876 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 2.4e-05
                 HHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   6 FrefDkDgdGkIdfeEfkellk 27 
                 F+  D+ g+ +I++eEf+++ +
  EFC36274.1 104 FKNTDTSGNRQISREEFVSFYQ 125
                 9999**************9865 PP

  == domain 4  score: 21.2 bits;  conditional E-value: 7.5e-08
                 HHHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellk 27 
                 +++ + + +D+D++G ++f+E++++l+
  EFC36274.1 137 DIDYALNYIDTDKSGSLSFQELINWLR 163
                 588999*****************9986 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.1   3.6e-07   0.00065       2      26 ..      13      37 ..      12      42 .. 0.91
   2 !   14.7   0.1   1.2e-05     0.021       8      24 ..      56      72 ..      52      80 .. 0.87
   3 !   13.8   0.0   2.3e-05     0.041       5      28 ..     103     126 ..     102     133 .. 0.91
   4 !   20.8   0.0   1.3e-07   0.00024       2      27 ..     138     163 ..     137     165 .] 0.93

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 3.6e-07
   EF-hand_6  2 lreaFklfDkdgdGkidaeElrkal 26
                ++++Fk++D+d++++i+++E+++++
  EFC36274.1 13 IHSLFKKYDQDNSNSINISEMKNLF 37
                679******************9876 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.2e-05
   EF-hand_6  8 lfDkdgdGkidaeElrk 24
                ++Dkd dGki+++E+ +
  EFC36274.1 56 YMDKDSDGKISFDEFFN 72
                57************965 PP

  == domain 3  score: 13.8 bits;  conditional E-value: 2.3e-05
   EF-hand_6   5 aFklfDkdgdGkidaeElrkalrk 28 
                 +Fk  D++g+ +i++eE+++++++
  EFC36274.1 103 LFKNTDTSGNRQISREEFVSFYQQ 126
                 69******************9985 PP

  == domain 4  score: 20.8 bits;  conditional E-value: 1.3e-07
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalr 27 
                 +++a +++D+d++G+++++El+++lr
  EFC36274.1 138 IDYALNYIDTDKSGSLSFQELINWLR 163
                 678999*******************8 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0   6.1e-05      0.11      25      52 ..      10      37 ..       2      39 .. 0.87
   2 !   22.6   2.7     4e-08   7.2e-05      15      53 ..      39      75 ..      32      76 .. 0.88
   3 !    6.7   0.0    0.0037       6.6      31      53 ..     103     125 ..     102     127 .. 0.84
   4 !   24.9   0.0   7.5e-09   1.3e-05       3      50 ..     113     160 ..     111     163 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.1e-05
   EF-hand_8 25 eeevdilfrefDtdgdGkisfeEFcvll 52
                 + +++lf++ D+d+++ i+  E  +l+
  EFC36274.1 10 RSVIHSLFKKYDQDNSNSINISEMKNLF 37
                56799***************99988887 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 4e-08
   EF-hand_8 15 rilglkkglseeevdilfrefDtdgdGkisfeEFcvlle 53
                + +g++  +s++++ ++ +++D d dGkisf+EF+++++
  EFC36274.1 39 ADMGIN--FSDDNLMAIQMYMDKDSDGKISFDEFFNYWT 75
                667889..9999999**********************96 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0037
   EF-hand_8  31 lfrefDtdgdGkisfeEFcvlle 53 
                 lf+  Dt g+  is eEF+ +++
  EFC36274.1 103 LFKNTDTSGNRQISREEFVSFYQ 125
                 78888999999999999999877 PP

  == domain 4  score: 24.9 bits;  conditional E-value: 7.5e-09
   EF-hand_8   3 gkItreelrrilrilglkk.glseeevdilfrefDtdgdGkisfeEFcv 50 
                  +I+ree+++++  l ++  + +  ++d  ++++Dtd++G +sf E ++
  EFC36274.1 113 RQISREEFVSFYQQL-YNNySANMADIDYALNYIDTDKSGSLSFQELIN 160
                 69********99443.44478*************************886 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.0   3.2e-05     0.057       3      24 ..      15      36 ..      13      38 .. 0.88
   2 !   18.3   0.1   6.4e-07    0.0011       8      21 ..      57      70 ..      55      77 .. 0.93
   3 ?    4.0   0.0     0.022        39      15      24 ..     114     123 ..     103     127 .. 0.85
   4 !   17.1   0.0   1.5e-06    0.0027       4      22 ..     141     159 ..     138     162 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.2e-05
                HHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeELktl 24
                 +F++ D +++  I+++E k+l
  EFC36274.1 15 SLFKKYDQDNSNSINISEMKNL 36
                58*****************994 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 6.4e-07
                H-SS-SSCE-HHHH CS
   EF-hand_5  8 iDlNgDGkIskeEL 21
                +D++ DGkIs++E+
  EFC36274.1 57 MDKDSDGKISFDEF 70
                8************9 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.022
                 CE-HHHHHHH CS
   EF-hand_5  15 kIskeELktl 24 
                 +Is+eE+  +
  EFC36274.1 114 QISREEFVSF 123
                 6******655 PP

  == domain 4  score: 17.1 bits;  conditional E-value: 1.5e-06
                 HHHHH-SS-SSCE-HHHHH CS
   EF-hand_5   4 tFqaiDlNgDGkIskeELk 22 
                 +++ iD++++G +s++EL 
  EFC36274.1 141 ALNYIDTDKSGSLSFQELI 159
                 4789*************95 PP

>> EF-hand_10  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.1     0.007        13      25      45 ..      15      35 ..      13      41 .. 0.88
   2 !   21.3   0.0     1e-07   0.00019      21      50 .]      98     127 ..      97     127 .. 0.96
   3 ?    0.2   0.0      0.39   6.9e+02      32      47 ..     147     162 ..     143     165 .] 0.55

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.007
  EF-hand_10 25 kLFkkcDkSksgrLegeEiee 45
                +LFkk D+ +s++++ +E+++
  EFC36274.1 15 SLFKKYDQDNSNSINISEMKN 35
                79************9999875 PP

  == domain 2  score: 21.3 bits;  conditional E-value: 1e-07
  EF-hand_10  21 eYAekLFkkcDkSksgrLegeEieeFyklL 50 
                  YA  LFk+ D+S + ++  eE++ Fy++L
  EFC36274.1  98 TYAALLFKNTDTSGNRQISREEFVSFYQQL 127
                 5**************************987 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.39
  EF-hand_10  32 kSksgrLegeEieeFy 47 
                 + ksg+L  +E+ + +
  EFC36274.1 147 TDKSGSLSFQELINWL 162
                 5556666555554444 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.5    0.0021       3.8      53     111 ..      10      71 ..       2      73 .. 0.78
   2 ?    3.5   0.0     0.048        87      93     111 ..     103     121 ..      98     123 .. 0.88
   3 ?    3.4   0.0     0.052        93      47      77 ..     129     159 ..     122     163 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0021
  SPARC_Ca_bdg  53 kepvawkFsklDtnsdkvlsksELaplrap...lvklehCikpflescDadkdkkislkEwc 111
                   ++ ++  F+k D+++ ++++ sE+++l      +   +    +  +  D d+d+kis  E+ 
    EFC36274.1  10 RSVIHSLFKKYDQDNSNSINISEMKNLFVAdmgINFSDDNLMAIQMYMDKDSDGKISFDEFF 71 
                   5678889*****************99976511155566666777788999*******99996 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.048
  SPARC_Ca_bdg  93 flescDadkdkkislkEwc 111
                   ++++ D+  +++is++E++
    EFC36274.1 103 LFKNTDTSGNRQISREEFV 121
                   79999***********997 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.052
  SPARC_Ca_bdg  47 knlkeckepvawkFsklDtnsdkvlsksELa 77 
                   +n+++    + +  + +Dt++ ++ls +EL 
    EFC36274.1 129 NNYSANMADIDYALNYIDTDKSGSLSFQELI 159
                   5677777889999999************996 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.5   9.3e-05      0.17      38      66 ..      43      71 ..      12      90 .. 0.78
   2 ?    2.0   0.0      0.11   1.9e+02      46      67 ..     139     160 ..     103     165 .] 0.72

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 9.3e-05
   EF-hand_4 38 skleedklekiwdladidedgkldfeefc 66
                 ++++d+l  i    d d+dgk+ f+ef 
  EFC36274.1 43 INFSDDNLMAIQMYMDKDSDGKISFDEFF 71
                46899**********************96 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.11
   EF-hand_4  46 ekiwdladidedgkldfeefci 67 
                 +   +  d d+ g+l f+e++ 
  EFC36274.1 139 DYALNYIDTDKSGSLSFQELIN 160
                 4445566888889999999875 PP

>> MecA_N  NTF2-like N-terminal transpeptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1       1.1   1.9e+03      64      64 ..      58      58 ..      11      84 .. 0.59
   2 ?   13.5   0.1   3.7e-05     0.067      21      67 ..     103     149 ..      98     159 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.1
                E CS
      MecA_N 64 d 64
                d
  EFC36274.1 58 D 58
                2 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 3.7e-05
                 HHCTB--BSSBSS-HHHHHHHHHHHCCCTT-EEEEE.EEEEEEEEETT CS
      MecA_N  21 aasllseqskkeisekeavekyqaiydglqvkklki.eakkvkkdken 67 
                 +++++++    +is++e+v+ yq+ y++ +++  +i + +  + d ++
  EFC36274.1 103 LFKNTDTSGNRQISREEFVSFYQQLYNNYSANMADIdY-ALNYIDTDK 149
                 5789999999***********************99952.333333333 PP

>> IFN-gamma  Interferon gamma
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.6     0.082   1.5e+02      15      56 ..      28      68 ..      10      93 .. 0.65
   2 ?   10.8   0.1   0.00019      0.34      42      85 ..     104     148 ..      97     157 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.082
   IFN-gamma 15 keiekLkeYfnasssdvadggsLfldilknwkeesdkkilqs 56
                 +i ++k+ f a+ + +  +++ ++ i + + ++sd ki   
  EFC36274.1 28 INISEMKNLFVAD-MGINFSDDNLMAIQMYMDKDSDGKISFD 68
                4677788888765.4555555556677777888888888655 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00019
   IFN-gamma  42 lknwkeesdkkilqsqivsfYfklFeklkdnq.viqksletiked 85 
                 +kn    ++++i + + vsfY +l++++  n   i  +l+ i  d
  EFC36274.1 104 FKNTDTSGNRQISREEFVSFYQQLYNNYSANMaDIDYALNYIDTD 148
                 6899999********************997651588777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       994  (0.0554409); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1042.24
//
Query:       EFC36275.1  [L=417]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.093   11.9   0.4       0.15   11.2   0.4    1.3  1  DUF3404   Domain of unknown function (DUF3404)


Domain annotation for each model (and alignments):
>> DUF3404  Domain of unknown function (DUF3404)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.4   8.4e-06      0.15       5      71 ..      13      80 ..       8     106 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.4e-06
                XXTTHHHHHHHHHHT--GGG-S-EEEHH.HHH..HH--GGGT-GGGGS--TTTS-HHHHHHHHHHHHH CS
     DUF3404  5 ladslperidkfqklfqqaealesadir.vlQslndyPtkLLlsdsqlPqfseyslkdiqelyklakq 71
                +++++ +r d fq+  +++ + e a i   + +ln++ ++LL  + + Pq++ y   ++++ +++ ++
  EFC36275.1 13 QQQKKLKRSDDFQNATNHEIDHEIATIDsEIKNLNQFKEELLIIKRMRPQTNVYYSAEMKKNASIVNN 80
                456677889**********99999999625669*********************98888877766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (417 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1364  (0.0760779); expected 358.6 (0.02)
Passed bias filter:                      672  (0.0374812); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.48
# Mc/sec: 2609.93
//
Query:       EFC36276.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-51  174.4   0.7    2.3e-51  174.1   0.7    1.1  1  adh_short        short chain dehydrogenase
    2.6e-37  128.6   0.4    3.3e-37  128.3   0.4    1.0  1  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
      4e-11   43.1   0.2    5.6e-11   42.7   0.2    1.1  1  KR               KR domain
    2.9e-05   23.6   0.2    4.3e-05   23.1   0.2    1.4  1  Epimerase        NAD dependent epimerase/dehydratase family
    0.00073   18.8   0.7    0.00097   18.4   0.7    1.1  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
  ------ inclusion threshold ------
      0.022   14.6   0.3       0.04   13.8   0.3    1.5  1  NAD_binding_10   NAD(P)H-binding
      0.029   13.8   0.1      0.054   12.9   0.1    1.6  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  174.1   0.7   8.9e-55   2.3e-51       1     189 [.       7     198 ..       7     203 .. 0.97

  Alignments for each domain:
  == domain 1  score: 174.1 bits;  conditional E-value: 8.9e-55
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHHHHHHHH.SSESEEEE---SS--SSGGGC CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealvekavkkl.gkldvLvnNAGitgsgpfsel 96 
                 k v++tGassGIG a+a  +a++G+k+++++r++++lee+++  +    +++ l+ q+Dvt+ e++++ ve a kk+  ++d+++nNAGi +s+p se 
  EFC36276.1   7 KLVVITGASSGIGEATAVLFAQKGYKLLLLARRKDRLEELVNDSRYSfnQDNTLIHQCDVTNVEDIRTGVELATKKFnLPVDCFINNAGIGHSSPLSEQ 105
                 689****************************************999998889*************************89******************** PP

                 SHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHHHHH CS
   adh_short  97 seeewervievNltgvflltravlpamlkqssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakelaptgirvnavaPGlvdTdmake 189
                 s ++  +vi+vN++gv++ +  v++ m+++++G+I+n+sS+ag++ + g ++Y+ sK+av++++++l+ e+a++++rv+++ PG+++++++  
  EFC36276.1 106 SLDKQYAVIDVNIKGVLNGINVVAKDMVQRQAGTIINISSIAGRKTMDGASVYCGSKFAVHAISETLRSEVASSKVRVVVISPGVTESEITGH 198
                 ***************************************************************************************999865 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.3   0.4   1.3e-40   3.3e-37       1     213 [.      13     229 ..      13     232 .. 0.96

  Alignments for each domain:
  == domain 1  score: 128.3 bits;  conditional E-value: 1.3e-40
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE...EEE--TTSHHHHHHHHHHHHHHH.SSEEEEEE-----EGCSS-GGGH-H CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgae...vlecDVtdeeqvealveevvekf.gklDilvnnagiapklkgpfletsr 92 
                   Ga sgIG+a+A ++a++G++++l  +++++ ++ v++   +++++   + +cDVt+ e++++ ve +++kf   +D+++nnagi ++  +p+ e s 
    EFC36276.1  13 GASSGIGEATAVLFAQKGYKLLLLARRKDRlEELVNDSRYSFNQDntlIHQCDVTNVEDIRTGVELATKKFnLPVDCFINNAGIGHS--SPLSEQSL 107
                   899******************9999999998**********99776544**********************889*************..******** PP

                   HHHHHHHHHHTHHHHHHHHHHHH.HCTSC.CEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTGGGGSTTHHH CS
  adh_short_C2  93 eefdraldvnlyslfllakaalp.lmkeg.gsivnlssvgaervvpnynaygaaKaalealtrylAvelgpkgiRvNavspgpikTlaasgikgfde 187
                   ++   ++dvn++++++ ++ +++ +++++ g i+n+ss+++++++++ ++y+ +K a++a++ +l  e+++ ++Rv ++spg+++ +++ + ++ +e
    EFC36276.1 108 DKQYAVIDVNIKGVLNGINVVAKdMVQRQaGTIINISSIAGRKTMDGASVYCGSKFAVHAISETLRSEVASSKVRVVVISPGVTESEITGHDEKLHE 204
                   ***********************8888889******************************************************************* PP

                   HHHHHHHHSTTSS-B-HHHHHHHHHH CS
  adh_short_C2 188 lleelearaplgrlgtpeevaeaalf 213
                   + e +++   lg   ++++vae +l+
    EFC36276.1 205 MVEGMKKGLTLGI-LKAQDVAESILY 229
                   ***********98.9*******9987 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.7   0.2   2.2e-14   5.6e-11       3     169 ..       9     178 ..       8     192 .. 0.85

  Alignments for each domain:
  == domain 1  score: 42.7 bits;  conditional E-value: 2.2e-14
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE---------TTT- CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvlrdklleem 100
                 ++itG+  g+G ++a   a+kg + l+l  R+ + +e  ++   ++++   +  + ++Dv++ +++++ +e +++++  p+   i+ Ag+ + ++l+e+
  EFC36276.1   9 VVITGASSGIGEATAVLFAQKGYKLLLLARRKDRLEELVNDSRYSFNQD--NTLIHQCDVTNVEDIRTGVELATKKFnLPVDCFINNAGIGHSSPLSEQ 105
                 68********************987777777755555555555555554..555679********************99******************** PP

                 -HHHHHHHHTTTTHHHHHHHHHTTT....S--SEEEEEEEHHHHH--TT-HHHHHHHHHHHHHHHHHHHHHHT CS
          KR 101 taedleqvlapKvkGawnLhelled....esldffvlfSSiagllgsagqanYaaaNaflDalaeyrrsqglp 169
                 + ++  +v+   +kG+ n  +++++    ++   ++ +SSiag   + g + Y      ++a+ e+ rs+ ++
  EFC36276.1 106 SLDKQYAVIDVNIKGVLNGINVVAKdmvqRQAGTIINISSIAGRKTMDGASVYCGSKFAVHAISETLRSEVAS 178
                 ***************99976666665777999*********************99988888888888876655 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.2   1.7e-08   4.3e-05       1     123 [.       9     151 ..       9     233 .. 0.74

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.7e-08
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC........EEEE--TT-HH......HHHHHHHHH..T-SEEEE--S---H....HH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl........elveldltdrs......alerlfkee..qpdavihlAavggv....aa 79 
                 +++tGa+  iG a++  +++kgy+++ l+r++++ ++  ++           ++++d+t+ +      +   + k++   +d+ i+ A++g+     ++
  EFC36276.1   9 VVITGASSGIGEATAVLFAQKGYKLLLLARRKDRLEELVNDSRysfnqdntLIHQCDVTNVEdirtgvE--LATKKFnlPVDCFINNAGIGHSsplsEQ 105
                 68*****************************7766666666669******9899999999994444331..2223323489********9996222257 PP

                 HHHSHHHHHHHHTHHHHHHHHHHHHHTCT....EEEEEEEGGGGTSCS CS
   Epimerase  80 ssedpadfieknlqgtlnlleaarkagvk....rllflsSsevYGkda 123
                 s +++ ++i+ n++g+ln ++++ k  v+     ++++sS  + G+++
  EFC36276.1 106 SLDKQYAVIDVNIKGVLNGINVVAKDMVQrqagTIINISS--IAGRKT 151
                 88888899**********9999998877655557777777..666554 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.7   3.8e-07   0.00097       1     166 [.       9     186 ..       9     191 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.8e-07
                      EEEETTTSHHHHHHHHHHHHHB-SEEEEEES-HHHHHHHHHH......-TTE..EEE....E--TT-HHHHHHHTT..T-SEEEE------.HH CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkkkpkkiillerdElklyeiekeleeelkkkkl..kveivpvigdvrdkerlekaleelkvdvvfhaAAlKh.VP 91 
                      v++tGa+  iG++    +++k   k++ll r   +l e+ ++ + +++++++  +   v+ + d+r   +l++   +l vd+ ++ A + h  P
       EFC36276.1   9 VVITGASSGIGEATAVLFAQKGY-KLLLLARRKDRLEELVNDSRYSFNQDNTliHQCDVTNVEDIRTGVELATKKFNLPVDCFINNAGIGHsSP 101
                      79*********998776666655.56666666667777777755555555440133445667777776666555555889**999999988469 PP

                      HHHH...SHHHHHHHHHHHHHHHHHHHHHTT-S....EEEEEEE...GGGSS--SHHHHHHHHHHHHHHHGGG--SSS--EEEEE CS
  Polysacc_synt_2  92 lvee...npleaiktNvlgtenvieaaieagvk....kvvliSt...DKAvnPtnvmGatKrlaekllqalakeseekktkfvvv 166
                      l e+   + + +i+ N+ g  n i++  +  v+    +++ iS+    K ++  +v+  +K +   +  +l++e +++k ++vv+
       EFC36276.1 102 LSEQsldKQYAVIDVNIKGVLNGINVVAKDMVQrqagTIINISSiagRKTMDGASVYCGSKFAVHAISETLRSEVASSKVRVVVI 186
                      999833346789******99987777666555422227899987444799999********999999999999998888887765 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.3   1.5e-05      0.04       1     179 [.      13     229 ..      13     234 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.5e-05
                     TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHH.......CTTTCEEEE--TT-CCHHHHHHT........T-SEEEES---TCC....... CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRnpeklaele.......aeeglevvegdvtdvedlaealk........gadaVvsalggggk....... 73 
                     GA+ ++G + +   +++ g+++ +l+R++++l+el        +++++ + + dvt+ved++  ++         +d  + ++g g++       
      EFC36276.1  13 GASSGIGEATAVLFAQK-GYKLLLLARRKDRLEELVndsrysfNQDNTLIHQCDVTNVEDIRTGVElatkkfnlPVDCFINNAGIGHSsplseqs 106
                     99999**9999866666.7*************96552333333456888999***********99988888877778777777666666765444 PP

                     .HHHH...............HHHHHHHHHHCT--EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEEEEEEE-CEE-S... CS
  NAD_binding_10  74 .deeg...............aknivdaakeagvkRfvlvsaigvgdevpgefgewnkellkaylaakraaeellrasgldwTivrpggLtde... 149
                      d                   + +++ + + +   ++ +s+i  ++  +g+          a++a  +    ++ +s++  ++++pg  + e   
      EFC36276.1 107 lD--KqyavidvnikgvlngINVVAKDMVQRQAGTIINISSIAGRKTMDGASVYC--GSKFAVHAISETLRSEVASSKVRVVVISPGVTESEitg 197
                     43..045788888888888555666788888888899999987665444433222..22235555566666678889999999999988766211 PP

                     .T--SEEEEETTSS-.---EEEHHHHHHHHHH CS
  NAD_binding_10 150 .pttkyrvvekgepf.kggsisradVAdvlva 179
                      +++  ++ve+ ++  + g    +dVA+ ++ 
      EFC36276.1 198 hDEKLHEMVEGMKKGlTLGILKAQDVAESILY 229
                     12333333333332202344577777777765 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   2.1e-05     0.054       2      70 ..      11      75 ..      10     146 .. 0.75
   2 ?   -3.0   0.0       1.4   3.7e+03     149     170 ..     154     175 ..     149     214 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.1e-05
                   EETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGC.CEEEEE--TT-HHHHHHH CS
  GDP_Man_Dehyd  2 iTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeelee.nlklhkgDltDssslerl 70
                   iTG +  iG  +a l+ +kgy+   + rr++      +e+l +d + + ++ n  +h++D+t+ + ++  
     EFC36276.1 11 ITGASSGIGEATAVLFAQKGYKLLLLARRKDR-----LEELVNDSRYSFNQdNTLIHQCDVTNVEDIRTG 75
                   9****9******************99999875.....5566666555555438889******98887654 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.4
                    --SHHHHHHHHHHHHHHHHHHH CS
  GDP_Man_Dehyd 149 PrsPYaaaKlyadwivvnyrea 170
                      s Y  +K + + i +  r +
     EFC36276.1 154 GASVYCGSKFAVHAISETLRSE 175
                    5677777777777776666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1543.08
//
Query:       EFC36277.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00081   19.0   0.0     0.0024   17.5   0.0    1.6  1  Exo_endo_phos    Endonuclease/Exonuclease/phosphatase family
  ------ inclusion threshold ------
      0.057   13.3   0.1       0.13   12.1   0.0    1.6  2  Exo_endo_phos_2  Endonuclease-reverse transcriptase


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   2.6e-07    0.0024      31     155 ..      11     157 ..       3     168 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 2.6e-07
                    T..SEEEEEEEBSCTCHHHHHHHHH.TTCEEEEECCH.....................................ECSSSTTSSEEEEEECSTEEEE CS
                    x..xxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxx.....................................xxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  31 a..DvlgLQEvdddelsriplllal.ggflgasstsp.....................................tgggggggnggavlsrfpltsl 86 
                    a  D+++LQE++ +++  +++ l+   +f++ ++  +                                     ++ + +++ng     +f++ s+
     EFC36277.1  11 AgcDLICLQETHKGWEKALNTSLIIsTHFPHQYWDHSnveqckpsgaavlarsyldikvsvlesgvegsvfpalHVLVKDRRNGH----SFQVLSV 102
                    345************9999999988844444444444566666666666677777777777777777777777766777777777....6777777 PP

                    EEEEEEETSSSSGCEEEEEEEEEEEEEEECCCHHGHHHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-SS CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  87 frrtfiefndlvaalrreplaakleqlniashrdhdlvrdlqllalllqvealnadrgapvivaGDfNa 155
                      r++ +f+d   a +      +                  +l   +  +e++ + ++ p++++GDfN 
     EFC36277.1 103 HLRPPLGFDDNQRANIELSALWTT--------------SSIRLKEMQSYLEQALRLSSLPLLIVGDFNE 157
                    777777777777777666655554..............567899999999999999************8 PP

>> Exo_endo_phos_2  Endonuclease-reverse transcriptase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1      0.56   5.1e+03      42      48 ..      40      46 ..      19      58 .. 0.67
   2 ?   12.1   0.0   1.5e-05      0.13      10      41 ..     126     157 ..     117     176 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.56
  Exo_endo_phos_2 42 khplWgs 48
                     +h+ W++
       EFC36277.1 40 PHQYWDH 46
                     4555555 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 1.5e-05
  Exo_endo_phos_2  10 psd.elenlestlekllselkspkiiilGDfNa 41 
                       s+ +l++++s le++l+  +  +++i+GDfN 
       EFC36277.1 126 TSSiRLKEMQSYLEQALRLSSL-PLLIVGDFNE 157
                      44458999***********997.9********6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       333  (0.0185733); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1249.22
//
Query:       EFC36278.1  [L=1268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.2e-08   32.9   0.0    3.4e-07   30.3   0.0    2.5  2  PAS           PAS fold
    1.2e-06   28.3   0.0    3.2e-06   27.0   0.0    1.7  1  PAS_8         PAS domain
    0.00097   19.4   0.1     0.0047   17.2   0.1    2.2  2  PAS_9         PAS domain
  ------ inclusion threshold ------
      0.091   13.0   0.1       0.33   11.2   0.1    2.0  1  DUF1059       Protein of unknown function (DUF1059)
       0.11   12.5   0.0       0.11   12.5   0.0    3.6  4  Spore_III_AF  Stage III sporulation protein AF (Spore_III_AF)
       0.16   12.3   0.0        0.4   11.0   0.0    1.7  1  PAS_4         PAS fold
        6.3    7.3   6.8        1.4    9.4   1.0    3.0  3  ABC_tran      ABC transporter


Domain annotation for each model (and alignments):
>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   0.0   1.3e-10   3.4e-07       2      65 ..     754     813 ..     753     856 .. 0.81
   2 ?   -3.1   0.0         3   7.6e+03      32      49 ..     876     893 ..     875     898 .. 0.84

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 1.3e-10
                 HHHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHH CS
         PAS   2 dlraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleql 65 
                  ++ai+ ++p p+f+++ +g+++ vN+a+  +lG+++e++ + ++  +++ ++++    l++q 
  EFC36278.1 754 LFQAIFRHTPLPMFILNSKGKFMSVNHAFVNMLGYNQEDLFSNKFASEFVSNEHE----LMQQI 813
                 5899**********************************************99665....32222 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3
                 HHHSSTHHHCTTSBGGGG CS
         PAS  32 ellGlsreevlgkslldl 49 
                  ++G++ +e +g++l+ +
  EFC36278.1 876 IITGIASNEEMGSNLSNS 893
                 589***********9865 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.0   1.2e-09   3.2e-06       1      45 [.     753     798 ..     753     815 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 1.2e-09
       PAS_8   1 erlralfesspdgiavvd.lgdrivdvNqaalellGys.adlkgell 45 
                 + ++a+f + p ++++++  g+ ++ vN a+  +lGy+ +dl   ++
  EFC36278.1 753 QLFQAIFRHTPLPMFILNsKGK-FMSVNHAFVNMLGYNqEDLFSNKF 798
                 679***************6666.***************777666555 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       2.8   7.1e+03      68      95 ..     648     675 ..     630     678 .. 0.71
   2 !   17.2   0.1   1.8e-06    0.0047       2      56 ..     764     812 ..     763     856 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.8
       PAS_9  68 lirkngetfwvlltaspvkdddgelvgi 95 
                 l+ ++g++++ +++ +  + d++ + ++
  EFC36278.1 648 LTSSSGKQIHHQVHSTQRRVDSQHVESL 675
                 4556777888778887777777777665 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 1.8e-06
       PAS_9   2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleq 56 
                  +++i n++g+  ++N a+ ++lGy+ e++   ++   f       ++++++++q
  EFC36278.1 764 LPMFILNSKGKFMSVNHAFVNMLGYNQEDLFSNKFASEF------VSNEHELMQQ 812
                 5799999*********************98887754444......2333333333 PP

>> DUF1059  Protein of unknown function (DUF1059)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   0.00013      0.33       6      39 ..     480     512 ..     477     519 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00013
     DUF1059   6 CgDvgpdCgfeitaeteeEvlrkvaeHakaaHgl 39 
                 Cg  + dCg + ta+ ++ + ++++ H +++H l
  EFC36278.1 480 CGT-VSDCGVHYTADPNDLISPRIQHHSRHSHML 512
                 554.57**************************75 PP

>> Spore_III_AF  Stage III sporulation protein AF (Spore_III_AF)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.88   2.3e+03      57     102 ..     347     407 ..     334     412 .. 0.73
   2 ?   -1.6   0.1      0.93   2.4e+03     118     144 ..     713     745 ..     698     755 .. 0.47
   3 ?    1.1   0.3      0.14   3.5e+02      82     151 ..     937    1028 ..     888    1072 .. 0.66
   4 ?   12.5   0.0   4.3e-05      0.11      31     110 ..    1161    1243 ..    1160    1253 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.88
  Spore_III_AF  57 sleeeleeikeegeelkeenkke...............aleeyeqrlekqikeelkeegye 102
                     ++++ ++++ +++++++n+++               +++ + ++ e+qi+++ ++++++
    EFC36278.1 347 LYNPNSVTPSSTATNAAANNNSQeylpstfipsyqldpTVDMMISNWENQIRQRQRQQKMQ 407
                   4566666777777777777777778888888888888899999999999999888876655 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.93
  Spore_III_AF 118 fgeiekvtitlte......kesekekeeesvek 144
                   + eie+++ ++++      +es+ ++++ ++e+
    EFC36278.1 713 PTEIESISFNFPPpptsnpSESSSNEQVANQEE 745
                   234666666666644433322223333333322 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.14
  Spore_III_AF   82 eeyeqrlekqikeelkeegyevkdveveieedeesrfgeiekvtitlte.........kesekekeeesvekVepVei...............a 151 
                    + y +++++++ +el e+ ++  ++++++ +  ++  ++i+k++ +            ++ + ++e++s ++V + +i               +
    EFC36278.1  937 DDYLSEMRESLIKELGESFVKNIEIRIKVGDASDE--DKIRKIVTEYDYdlviacqpcGFVTTAEEGKSRQPVRRRDIkgtsfkqgedkkvspR 1028
                    44555555555555554444555555554444444..788888887777888888889888888888888888888885555555544443331 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 4.3e-05
  Spore_III_AF   31 lilailsPvlsllnkdldlelaa.esesleeeleeikeegeelkeenkke...aleeyeqrlekqikeelkeegyevkdvevei 110 
                    l++ +++P++++ ++ ++++++   + s+++++++ +++g++ ++  +      l+   +++++qi +e+  +g+ev dv++ i
    EFC36278.1 1161 LVFQMINPITNMTDRRFNQSVSStYQFSTSASTSSTSQNGKDKRSLTNPIlpqFLDRIPSQISNQILKEIY-KGIEVIDVNLPI 1243
                    7999****************987667777777777777776666555543444677777777777777777.999999988765 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00016       0.4       1      52 [.     759     809 ..     759     820 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00016
       PAS_4   1 ldslpdalavldpdgrvlyaNaaaaelfgappeellGktla.ellpeedaarl 52 
                 + ++p + ++l++ g+++ +N a+  ++g+ +e+l   ++a e+++ e  ++l
  EFC36278.1 759 FRHTPLPMFILNSKGKFMSVNHAFVNMLGYNQEDLFSNKFAsEFVSNE--HEL 809
                 6799**********************************9998888864..333 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   1.0   0.00054       1.4      79     119 ..      85     157 ..      55     164 .. 0.61
   2 ?   -3.2   0.0       4.4   1.1e+04      57     126 ..     809     883 ..     790     886 .. 0.51
   3 ?   -2.7   0.1       3.1   7.8e+03      30      83 ..    1149    1203 ..    1142    1239 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00054
                 H................................HHHTC..HHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHH CS
                 x................................xxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  79 n................................esdee..iekalsklglkelkdtvvksspssLSgGqkqrval 119
                                                  ++  +   +   s+ + ++ ++++++ss +++SgG+kqr++l
  EFC36278.1  85 PpqgifpaqtfteittkfggsvqyrnrkslgseQE--KlsSSSSSSHSDVIHHHHHNINSSSNNFSGGEKQRIQL 157
                 03333333333333556666777666666653323..233666677777788899999999***********998 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 4.4
                 CCHCEEEE-SS--S-TTSBHHHH....HHHTCHHHHHHHSTTGGTTCBGESTTS.GGS-HHHHHHHHHHHHHHHT CS
                 xxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  57 lrkeigvlpqepqlfpeltvren....esdeeiekalsklglkelkdtvvkssp.ssLSgGqkqrvalarallkk 126
                 l ++i  +++e  l++++ ++++     +d e  ++ ++  +  l+d +++  + ++L  G + + ++   ++++
  EFC36278.1 809 LMQQIHKCSHEGGLNNGVANQQHyslsFKDYEGLEIQAENTIYVLRDVIMTVPApQQLASGIQIKSCIITGIASN 883
                 445555555555555555444445544222222222333333333333333322477777777777776666665 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3.1
                  HHTTSS--SEEEEEET.TCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHHHHHT CS
                  xxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   30 llagllkpteGeilld.gkdlkeqeleslrkeigvlpqepqlfpeltvrenesde 83  
                   + +   pt+ ++ ++  +++++ + ++++++++   q ++  ++++  +n +d+
  EFC36278.1 1149 QIVETDLPTKSQLVFQmINPITNMTDRRFNQSVSSTYQFSTSASTSSTSQNGKDK 1203
                  5555566666666666556677777788888888888887777777777773333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1397  (0.0779185); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.00u 0.32s 00:00:01.32 Elapsed: 00:00:00.57
# Mc/sec: 6755.48
//
Query:       EFC36279.1  [L=217]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      210  (0.0117129); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 1245.37
//
Query:       EFC36280.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-16   58.2   0.5    9.8e-11   41.1   0.2    3.3  3  TAP_C     TAP C-terminal domain
    1.9e-06   27.6   1.3       0.14   12.0   0.3    3.4  3  UBA_4     UBA-like domain
  ------ inclusion threshold ------
      0.049   13.6   0.1      0.075   13.0   0.1    1.3  1  DUF1110   Protein of unknown function (DUF1110)


Domain annotation for each model (and alignments):
>> TAP_C  TAP C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0    0.0002       1.2       2      34 ..      45      77 ..      44      83 .. 0.90
   2 !    5.1   0.0    0.0029        17       4      31 ..      83     111 ..      80     114 .. 0.87
   3 !   41.1   0.2   1.6e-14   9.8e-11       1      49 []     116     164 ..     116     164 .. 0.98

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0002
                HHHHHHHHH-B-HHHHHHHHSSTTT-HHHHHHH CS
       TAP_C  2 mvqafstqtgMnlewsqkcLeqnnWdyerAlqv 34
                m++a+ + tg   e + ++L   +W++e A ++
  EFC36280.1 45 MINALGNYTGESEEKCLRYLIFFGWNFELAYKA 77
                99999999**********************987 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0029
                 HHHHHHH-B.-HHHHHHHHSSTTT-HHHH CS
       TAP_C   4 qafstqtgM.nlewsqkcLeqnnWdyerA 31 
                 q+++++t++ nl  +++ Le++++d + +
  EFC36280.1  83 QELCERTKLsNLFLARRILEEAQFDVTLC 111
                 8999*****78889***********9865 PP

  == domain 3  score: 41.1 bits;  conditional E-value: 1.6e-14
                 HHHHHHHHHH-B-HHHHHHHHSSTTT-HHHHHHHHHHHG..GGS-GGGB CS
       TAP_C   1 emvqafstqtgMnlewsqkcLeqnnWdyerAlqvFeelkakgkIPpeAF 49 
                 e+v  ++++t++ + ++++cL+q +W+++ Alq   el + + +P +AF
  EFC36280.1 116 ELVLYLMNRTNLVHVFAYDCLQQYQWNINSALQRVFELASMNRLPSHAF 164
                 6999********************************************9 PP

>> UBA_4  UBA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.0   6.5e-05      0.39      11      32 ..      53      74 ..      46      76 .. 0.96
   2 ?    1.6   0.0      0.04   2.4e+02      18      29 ..      97     108 ..      83     111 .. 0.88
   3 !   12.0   0.3   2.4e-05      0.14      19      38 ..     133     152 ..     132     155 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 6.5e-05
       UBA_4 11 TGadeekArqlLeannWdLerA 32
                TG +eek+ ++L   +W+ e A
  EFC36280.1 53 TGESEEKCLRYLIFFGWNFELA 74
                999*****************98 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.04
       UBA_4  18 ArqlLeannWdL 29 
                 Ar++Le +++d+
  EFC36280.1  97 ARRILEEAQFDV 108
                 9*********98 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 2.4e-05
       UBA_4  19 rqlLeannWdLerAislyFd 38 
                  ++L++ +W+++ A+++ F+
  EFC36280.1 133 YDCLQQYQWNINSALQRVFE 152
                 579****************8 PP

>> DUF1110  Protein of unknown function (DUF1110)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   1.3e-05     0.075     101     150 ..      81     130 ..      73     159 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.3e-05
     DUF1110 101 gdqylaernAlakLreakedaeeAyasvdrCrghLdavllLLdhpelPgV 150
                   q+l er  l +L  a++  eeA   v  C  +++ vl+L+++ +l  V
  EFC36280.1  81 LSQELCERTKLSNLFLARRILEEAQFDVTLCHQRMELVLYLMNRTNLVHV 130
                 568999**************************************999776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1282.65
//
Query:       EFC36281.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00054   19.2   0.2     0.0033   16.7   0.0    1.9  2  Peptidase_M56    BlaR1 peptidase M56
     0.0047   17.2   3.7      0.016   15.5   0.5    2.3  2  Orf78            Orf78 (ac78)
     0.0082   15.7   4.0      0.056   12.9   0.4    2.2  2  Nodulin-like     Nodulin-like
  ------ inclusion threshold ------
      0.045   14.4   1.3      0.095   13.3   1.3    1.5  1  Ctr              Ctr copper transporter family
      0.076   11.8   0.0       0.11   11.2   0.0    1.2  1  DUF2207          Predicted membrane protein (DUF2207)
      0.083   12.5   0.3        1.8    8.1   0.1    2.1  2  CD34_antigen     CD34/Podocalyxin family
       0.14   12.2   1.5        3.2    7.8   0.0    2.2  2  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe
       0.25   11.8   1.8        1.8    9.0   0.4    2.2  2  DUF2663          Protein of unknown function (DUF2663)
       0.33   11.3   5.0       0.62   10.4   0.1    2.4  2  DUF4064          Protein of unknown function (DUF4064)
       0.35   11.2   3.5         11    6.4   0.5    2.7  3  Sigma_reg_N      Sigma factor regulator N-terminal


Domain annotation for each model (and alignments):
>> Peptidase_M56  BlaR1 peptidase M56
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.15   2.7e+02      88     130 ..      31      71 ..      11      85 .. 0.71
   2 !   16.7   0.0   1.8e-06    0.0033      62     151 ..     142     234 ..     122     237 .] 0.67

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.15
  Peptidase_M56  88 alatdvkkvewktilkillliWivgalilllyliaallvlkkr 130
                    +  +++ k++ k+i   +ll++i  +l+++l  + +l ++  r
     EFC36281.1  31 ENRKEIVKLKAKKI--GILLVVISSCLVCFLLGVGSLYLVATR 71 
                    55556666666666..789999999999999988888777655 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 1.8e-06
  Peptidase_M56  62 tskinsaaskaplasaaskvlddkas....alatdvkkvewktilkillliWivgalilllyliaallvlkkrfvrklgklraeelkeaLkeak 151
                    t +i + +   +++ ++s++  ++a+     +++++++   +t  ++l + +iv++++ + +++  +lvl  +fv ++g+ ++++++e++ke +
     EFC36281.1 142 THAITTFNYLKKFTPNNSTICYSNAEetifTFNEPIHTTTISTTQQVLFY-FIVISVLAFCFFMVMVLVLGFYFVERKGEKKDKSQYEEIKEGE 234
                    333333333444444444444444444578999*****999999777765.4555555567777777778877*****************9875 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1      0.11   1.9e+02      55      93 ..      36      74 ..      16      82 .. 0.51
   2 !   15.5   0.5     9e-06     0.016      42      97 ..     169     224 ..     144     230 .. 0.68

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.11
       Orf78 55 naaekaqalnillisllavvcvlvllyv.iyYfvilrerq 93
                  + ka+ +  +l+++++   v+ ll v  +Y v +r  +
  EFC36281.1 36 IVKLKAK-KIGILLVVISSCLVCFLLGVgSLYLVATRLSE 74
                2233333.33455555555555555544145666666555 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 9e-06
       Orf78  42 saaeknditekesnaaekaqalnillisllavvcvlvllyviyYfvilrerqkssv 97 
                 ++ + n+  ++++ +++++     ++is+la+   +v++ v+ ++++ r+ +k+ +
  EFC36281.1 169 TIFTFNEPIHTTTISTTQQVLFYFIVISVLAFCFFMVMVLVLGFYFVERKGEKKDK 224
                 3333333333333357778888899999999999999999**99999999777755 PP

>> Nodulin-like  Nodulin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.4   3.1e-05     0.056      67     115 ..      48      97 ..      36     103 .. 0.82
   2 ?    4.1   0.2     0.015        27     188     220 ..     178     210 ..     128     220 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.1e-05
  Nodulin-like  67 vvllvgaamg.lvGYgvvwLvvtesiaklpywllfllillaanseawlnT 115
                   +v++ ++  + l+G g ++Lv t+  +++ +  +  +++  + s +++n 
    EFC36281.1  48 LVVISSCLVCfLLGVGSLYLVATRLSEQIDVQYVHNCCFAVGTSYCYMNS 97 
                   34444455552579**********************************96 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.015
  Nodulin-like 188 pkkkeersesavFlvllvisvllavyllvvsil 220
                    +++ ++ ++  F+++ +  +++++++++v +l
    EFC36281.1 178 HTTTISTTQQVLFYFIVISVLAFCFFMVMVLVL 210
                   456667778889999988888888888887766 PP

>> Ctr  Ctr copper transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   1.3   5.3e-05     0.095      25     143 ..      51     214 ..      48     216 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.3e-05
         Ctr  25 agsciglfllaifyeflralrerlerewdrhl.a.............rsrekrkaassplvdssssseeeaea.......................... 83 
                 + sc+++fll ++  +l a   rl++++d +  +             +s+ ++ ++ + +v++++ s +                              
  EFC36281.1  51 ISSCLVCFLLGVGSLYLVA--TRLSEQIDVQYvHnccfavgtsycymNSHDSNYEYCEYKVSYAKLSPT---Ivsnpnqfnssfiseqcqqimpsntha 144
                 679*********9988884..455555554443245566777777774444444444444443333333...1334777888999999999999999** PP

         Ctr  84 ............kstsslskseakksvrttpeqqlirallyvvqvllaYilMLlvMtyNvglflavilGagv 143
                             ++++ ++++ +++ +++++   +  +++ + q +l Y++  +v  +   +++ ++lG ++
  EFC36281.1 145 ittfnylkkftpNNSTICYSNAEETIFTFNEP--IHTTTISTTQQVLFYFIVISVLAFCFFMVMVLVLGFYF 214
                 ********997777777777777777777777..*******************************9999875 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   6.2e-05      0.11     375     437 ..      31     218 ..      15     232 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6.2e-05
     DUF2207 375 kgkkklkklsalglgliilglilillallllvll................................................................. 408
                 +++k++ kl a  +g++++ +i ++l+++ll+++                                                                 
  EFC36281.1  31 ENRKEIVKLKAKKIGILLV-VISSCLVCFLLGVGslylvatrlseqidvqyvhnccfavgtsycymnshdsnyeyceykvsyaklsptivsnpnqfnss 128
                 5556666666555555333.333444455555555677788899******************************************************* PP

     DUF2207 409 .............................................................lvfllilllillliaiivlllfsrllgrr 437
                                                                              ++f++i +l++ +++++vl+l  ++++r 
  EFC36281.1 129 fiseqcqqimpsnthaittfnylkkftpnnsticysnaeetiftfnepihtttisttqqvlFYFIVISVLAFCFFMVMVLVLGFYFVERK 218
                 ******************************************************999998888888888888888888888877777774 PP

>> CD34_antigen  CD34/Podocalyxin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.1     0.001       1.8     108     138 ..      46      76 ..      20      92 .. 0.69
   2 ?    2.5   0.0     0.051        92     108     148 ..     194     231 ..     174     237 .] 0.67

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.001
  CD34_antigen 108 lialvt.sglllaiLlvagyYgclhrRlsksk 138
                   + ++v+ s l+ ++L+v+ +Y  +  Rls + 
    EFC36281.1  46 ILLVVIsSCLVCFLLGVGSLY-LVATRLSEQI 76 
                   4444551456778899*****.7799999765 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.051
  CD34_antigen 108 lialvtsglllaiLlvagyYgclhrRlskskagerLgEelq 148
                   +i+++     ++++lv g Y  +  R   +k++++  Ee++
    EFC36281.1 194 VISVLAFCFFMVMVLVLGFY--FVERKGEKKDKSQ-YEEIK 231
                   55555545444555555556..5788888899988.67765 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0    0.0018       3.2      27      58 ..      38      69 ..      16      92 .. 0.86
   2 ?    3.2   0.6     0.049        89      37      58 ..     189     210 ..     181     221 .. 0.58

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0018
  Phage_holin_3_6 27 keeakragsgagllgaagvlallalllllval 58
                     k +ak++g++++++   +v+ ll++++l + +
       EFC36281.1 38 KLKAKKIGILLVVISSCLVCFLLGVGSLYLVA 69
                     5599**********************998876 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.049
  Phage_holin_3_6  37 agllgaagvlallalllllval 58 
                      +  +++  vla++ ++++++ l
       EFC36281.1 189 LFYFIVISVLAFCFFMVMVLVL 210
                      4445555555555555555444 PP

>> DUF2663  Protein of unknown function (DUF2663)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0      0.13   2.4e+02      14      78 ..      38     102 ..      30     125 .. 0.62
   2 ?    9.0   0.4     0.001       1.8      40      89 ..     182     231 ..     146     233 .. 0.63

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.13
     DUF2663  14 klekrllllsllallvlllfliyvlikssslssllsallessvlllllllvallyvavkllkkKa 78 
                 kl++++  + l+ + + l+ +++ +   + +++ ls  ++ + +    ++v ++y+ ++     +
  EFC36281.1  38 KLKAKKIGILLVVISSCLVCFLLGVGSLYLVATRLSEQIDVQYVHNCCFAVGTSYCYMNSHDSNY 102
                 45554444444444444444444434466667777777777777777777777777777665555 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.001
     DUF2663  40 kssslssllsallessvlllllllvallyvavkllkkKaeKaEk.efhaLr 89 
                  s+++++l+ +++  svl +  ++v++l++ +++++ K eK++k ++++++
  EFC36281.1 182 ISTTQQVLFYFIV-ISVLAFCFFMVMVLVLGFYFVERKGEKKDKsQYEEIK 231
                 3445555555544.4555555556666666777777777776652577766 PP

>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   1.6      0.16   2.9e+02      82     102 ..      39      58 ..      36      59 .. 0.67
   2 ?   10.4   0.1   0.00035      0.62      42      82 ..     166     210 ..     119     229 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.16
     DUF4064  82 lkknkkvsGilfiiaailslf 102
                 lk  kk++ +l++i+++l++f
  EFC36281.1  39 LK-AKKIGILLVVISSCLVCF 58 
                 33.455777788899999998 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00035
     DUF4064  42 e....qalsgedasavleflstllivlgvialiaivlgivgalll 82 
                        +++  ++++ +  +++l++++vi+++a+ ++ v +l+l
  EFC36281.1 166 AeetiFTFNEPIHTTTISTTQQVLFYFIVISVLAFCFFMVMVLVL 210
                 14555778888999999999**********999999999999876 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.0     0.019        33      13      46 ..      44      77 ..      34     111 .. 0.78
   2 ?   -2.0   0.1       2.5   4.6e+03      38      58 ..     155     176 ..     142     192 .. 0.46
   3 ?    6.4   0.5    0.0059        11      15      47 ..     192     225 ..     180     233 .. 0.54

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.019
  Sigma_reg_N 13 lrivlislivlllifvilvvtllylaekegnklr 46
                 + i l++++++l+ f++ v +l  +a+  +++++
   EFC36281.1 44 IGILLVVISSCLVCFLLGVGSLYLVATRLSEQID 77
                 5678888888888888888877777766666664 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.5
  Sigma_reg_N  38 aekegnkl.revlelaveitsP 58 
                  ++++++    ++ e+ +++ +P
   EFC36281.1 155 TPNNSTICySNAEETIFTFNEP 176
                  4444444313333444455555 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0059
  Sigma_reg_N  15 ivlislivlllifvilvvtllyl.aekegnklre 47 
                   ++is++++ +++v+ +v++ y+ + k ++k  +
   EFC36281.1 192 FIVISVLAFCFFMVMVLVLGFYFvERKGEKKDKS 225
                  4566665555555555555556543333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1465  (0.0817112); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 1473.04
//
Query:       EFC36282.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.2e-13   48.9   0.0    7.6e-13   48.4   0.0    1.2  1  SBP_bac_3  Bacterial extracellular solute-binding proteins, f


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.4   0.0   4.2e-17   7.6e-13      28     177 ..     104     259 ..      90     289 .. 0.76

  Alignments for each domain:
  == domain 1  score: 48.4 bits;  conditional E-value: 4.2e-17
                 HHHHHHHHCT-EEEEEE......-.SGGGHHHHHHTTSSSEEESSEB--HHHHTTEEEES.ESEEEEEEEEEEE.TTSHGTCCHSSCGCG..TTSEEEE CS
                 xxxxxxxxxxxxxxxxx......x.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxx.xxxxxxxxxxxxxxx..xxxxxxx RF
   SBP_bac_3  28 lakaiakrlgvkvefvp......v.swdelipalksgkvDiaiaaititpeReekvdFsq.pyfsagqvllvrk.kdaskissiksladL..kgkkvgv 115
                 ++k+i k+ g+ ++ ++         +++l +a++sgk+D+++a++t + eR +kv F    y   + + l    +++  i+ ++   dL   g  v+v
  EFC36282.1 104 IVKNINKQYGLALTAKFfsinttDgFFESLKAAVDSGKCDVVVADVTPSTERTTKVHFQGcQYGAVSDAYLRGPlASNLTINRHT---DLnrTGIIVAV 199
                 56667777777444443333333247888889**************************984555556666655555555555555...99434559*** PP

                 ETTSHHHHHHHHHHHCTSEEEEESSHHHHHHHHHTTSSSEEEEEHHHHHHHHHHCCGCCEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 116 qagstaeellkeelkkgaeivefdtleealqaLkngrvdavvadspvlaylvkknpdkkvvl 177
                  +g+t+ee+++ +++  a+i    ++++a++ ++n ++ a++++   ++ ++ +np+  +  
  EFC36282.1 200 YQGTTHEEYARANFQ-AATI-LAVSYDDAFLYVANSKAHAMIGNLLDVNAWLSNNPGVCKSC 259
                 ***********9775.4454.5669*******************************987655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1827.70
//
Query:       EFC36283.1  [L=931]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.5e-21   76.1  20.7    2.5e-21   76.1  20.7    1.7  2  ABC2_membrane  ABC-2 type transporter
    5.3e-15   56.1   0.0    5.3e-15   56.1   0.0    2.3  2  ABC_tran       ABC transporter
  ------ inclusion threshold ------
      0.018   14.8   0.4      0.049   13.4   0.4    1.7  1  AAA_29         P-loop containing region of AAA domain
      0.027   14.0   0.0      0.048   13.2   0.0    1.3  1  AAA_25         AAA domain
      0.049   14.2   0.0      0.049   14.2   0.0    2.4  2  AAA_18         AAA domain
      0.049   14.1   0.1      0.049   14.1   0.1    3.3  3  AAA_23         AAA domain
        6.2    6.8   6.6       0.72    9.8   0.5    2.6  3  PDR_CDR        CDR ABC transporter


Domain annotation for each model (and alignments):
>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.1  20.7   9.8e-25   2.5e-21       3     210 .]     636     841 ..     635     841 .. 0.91
   2 ?   -3.1   0.9       1.6   4.2e+03      53      67 ..     882     896 ..     864     908 .. 0.53

  Alignments for each domain:
  == domain 1  score: 76.1 bits;  conditional E-value: 9.8e-25
  ABC2_membrane   3 ikallkreflqrwrdpslgllwrliqplllalvfgtvfgnlg.nsedglnrpgllffsvlflafsaltsvapvferergvlerelvsplyslsayv 97 
                    i++ll+r +   +r++ + +l++l++ +++++v+g +f +++ +  +  +   ++ f+ l++++++  ++  + + + ++l++e++s  y++sa++
     EFC36283.1 636 ILILLQRIYTVKFRNWKTEILSPLLEKVIISVVIGILFLQIDpT--NMSMKGKIFSFLNLNISLTFGLGL-KTLVGQIPNLMQERNSTSYRVSAFF 728
                    7899***********************************88732..222347777777777775555555.7788899****************** PP

  ABC2_membrane  98 lakvlvelpvsllqalifllivyflvgldls..rfflflllllltalaasslgllisalapsfedasqlaslvllpllllsGffipidsmpkwlqw 191
                    +ak + + +  ++  ++f +ivyf+ gld++  r+f f+l++ l+ l+++s++ ++ +l p     +++++++ l+++lls ++  i++   ++ w
     EFC36283.1 729 IAKSIEDTIDFTVYPTVFGIIVYFMCGLDYDpgRVFSFILIFALFNLTSMSVAQALVSLIPVPSFLNFISPVISLVFILLSSAY-GITKTD-YITW 822
                    *******************************9999************************************************9.888888.**** PP

  ABC2_membrane 192 iaylnPltyavealrsnlf 210
                    + y+++l+ya++al +n+f
     EFC36283.1 823 MGYFSYLYYAFRALAINEF 841
                    ***************9997 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.6
  ABC2_membrane  53 pgllffsvlflafsa 67 
                    ++ +++++lfl f++
     EFC36283.1 882 MMWIYTAILFLYFIF 896
                    444444444444333 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -13.9  13.1         7   1.8e+04      41      41 ..     140     140 ..      23     212 .. 0.57
   2 !   56.1   0.0   2.1e-18   5.3e-15       1     136 [.     315     474 ..     315     475 .. 0.87

  Alignments for each domain:
  == domain 1  score: -13.9 bits;  conditional E-value: 7
                 E CS
                 x RF
    ABC_tran  41 e 41 
                 +
  EFC36283.1 140 R 140
                 0 PP

  == domain 2  score: 56.1 bits;  conditional E-value: 2.1e-18
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--.SEEEEEETTCEGGG.......B-HHHCCHCEEEE-SS.--S-TTSBHHHH........... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxx.xxxxxxxxxxxx........... RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkp.teGeilldgkdlke.......qeleslrkeigvlpqe.pqlfpeltvren........... 79 
                 lkn++  + +g+++ai+G+ G+GKStLl++l+g      +G+i ++g+   +       ++  ++++ ++++ ++ +  +  ltv+e            
  EFC36283.1 315 LKNINGFVAPGKLTAILGPMGSGKSTLLRILSGRGARiYSGDIYINGQLAMNsekqfirIDSGRFKSLVSFVAKDfTPSNMSLTVKEIlqfavrlklps 413
                 799******************************9776689999888665555467777788999999999999996666667778888*********** PP

                 ........HHHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTT CS
                 ........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  80 ........esdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpt 136
                         ++d++++ +ls++gl +++++      ssLS G+k+r+ +a   +   +++ll  pt
  EFC36283.1 414 ksqnplwtTRDDRLALLLSSYGLRGKEHSLY----SSLSSGEKRRLTIAVQNVLFHRIVLLEYPT 474
                 ******9999999************888888....**************9999888888887666 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.4   1.9e-05     0.049      24      39 ..     327     342 ..     320     347 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.9e-05
      AAA_29  24 atlltGpsGsGKSTll 39 
                  t + Gp GsGKSTll
  EFC36283.1 327 LTAILGPMGSGKSTLL 342
                 799************8 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   1.9e-05     0.048      17      50 ..     309     342 ..     294     352 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.9e-05
      AAA_25  17 apppprrwlvkgllpagelallaGapgtGKttla 50 
                  +p+p  + + g+++ g+l+++ G+ g+GK+tl+
  EFC36283.1 309 GSPKPILKNINGFVAPGKLTAILGPMGSGKSTLL 342
                 478888899***********************97 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   2.6       3.9   9.9e+03      50      82 ..     186     231 ..     146     241 .. 0.43
   2 ?   14.2   0.0   1.9e-05     0.049       3      30 ..     330     356 ..     329     386 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.9
      AAA_18  50 krldedkldklldaleenss.............aleegknlvidgh 82 
                 + +  ++++++ ++++   +             + ++g++  +d h
  EFC36283.1 186 RSITLKRQNSNNNNNKDDENisnsisldrivdnDTHHGHHHHVDFH 231
                 2222222222222222222122333344455554444444445555 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 1.9e-05
      AAA_18   3 ltGtpGvGKttlakeLskrlgfgvnlrd 30 
                 + G++G+GK+tl + Ls r+   + ++d
  EFC36283.1 330 ILGPMGSGKSTLLRILSGRG-ARIYSGD 356
                 89**************9884.3333344 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.0   6.4         7   1.8e+04      60     124 ..     170     209 ..      95     249 .. 0.58
   2 ?   14.1   0.1   1.9e-05     0.049      20      39 ..     326     345 ..     298     347 .. 0.88
   3 ?    1.7   0.4      0.13   3.2e+02     148     197 ..     579     625 ..     507     628 .. 0.58

  Alignments for each domain:
  == domain 1  score: -5.0 bits;  conditional E-value: 7
      AAA_23  60 ksdveiesegkvkayveltfenkdgrytrsiererelskkkgkttkkaklelleideleqfisel 124
                 ++                         ++++ ++ ++  +  + t k + ++ + ++ +++is++
  EFC36283.1 170 NN-------------------------NMNMNNNSSVEGERRSITLKRQNSNNNNNKDDENISNS 209
                 11.........................12222222222222222222222222222222222222 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 1.9e-05
      AAA_23  20 gltlItGpNGaGKTTildAi 39 
                 +lt+I Gp G+GK+T+l+ +
  EFC36283.1 326 KLTAILGPMGSGKSTLLRIL 345
                 79**************9865 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.13
      AAA_23 148 l...kdkkerleelekeleeledekkllekleqekekekeleeleeeleeilk 197
                 +   +++++r++ l ke+ee+ de          ++ ++el  l++++e+i+ 
  EFC36283.1 579 RhmtETELKRVDTLDKEYEEKLDEYYIP------QKHREELPYLQNTIESIQT 625
                 1222333334444444444444444333......3456677777777777765 PP

>> PDR_CDR  CDR ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.5   3.8e+03      24      43 ..     348     367 ..     346     371 .. 0.79
   2 ?   -2.9   0.2       2.6   6.7e+03      53      71 ..     763     781 ..     760     785 .. 0.79
   3 ?    9.8   0.5   0.00028      0.72      24      76 ..     859     913 ..     856     919 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.5
     PDR_CDR  24 pGqeyVsGddYlelsfgyss 43 
                  G+ + sGd+Y++ ++  +s
  EFC36283.1 348 RGARIYSGDIYINGQLAMNS 367
                 5788889*****99887765 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.6
     PDR_CDR  53 liaflifflalyllateli 71 
                 ++ f+++f +++l  +++ 
  EFC36283.1 763 VFSFILIFALFNLTSMSVA 781
                 6789999999998888765 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00028
     PDR_CDR  24 pGqeyVsGddYlelsfgysssh..lwrnfgiliaflifflalyllatelisaeks 76 
                 p  +y +G+ +le+++g ++    +w    il++++if  +l  + + ++  +ks
  EFC36283.1 859 PSGQYTNGTLFLEKAYGITEPYymMWIYTAILFLYFIFCKILAYIGLRFVYGKKS 913
                 5567899**********99654449******************999999988877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (931 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1618  (0.0902449); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.91u 0.34s 00:00:01.25 Elapsed: 00:00:00.53
# Mc/sec: 5302.42
//
Query:       EFC36284.1  [L=726]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-29  102.0   1.6    5.5e-29  101.8   0.2    1.8  2  DUF4241   Protein of unknown function (DUF4241)


Domain annotation for each model (and alignments):
>> DUF4241  Protein of unknown function (DUF4241)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.22   3.9e+03      94     117 ..     342     367 ..     341     398 .. 0.63
   2 !  101.8   0.2   3.1e-33   5.5e-29       1     186 []     522     723 ..     522     723 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.22
     DUF4241  94 ffDakafealsefee..slleeepkk 117
                 +fD+++fe+++e+++  ++++  +k+
  EFC36284.1 342 VFDEENFEKFKEYDAsfNVYTPRCKS 367
                 69999999999999944333333333 PP

  == domain 2  score: 101.8 bits;  conditional E-value: 3.1e-33
     DUF4241   1 lklpSGrlvaaDPldesesepftetvppGt..ypvelavaevedegaedrvaaarlv.................fsdepavrwelAllgeqd..l.ael 77 
                 ++++S++++a+DP+  s+  ++ e+v++G   ++++++++ ++d+g++d +++a++v                 + +++ +++    +++++  l +e+
  EFC36284.1 522 FRMESNTMLATDPF-LSDGGVYFENVREGLwqWNTTNKQQGYCDGGYFDPNVTAQFVavhtdylhllntsniwlIPKDRTEEYG--GEYNRNeyLnYEM 617
                 689***********.9*************9999****************************************97777777775..5555554355777 PP

     DUF4241  78 eege.f...fgygVDaGlacffDakafealsefee......slleeepkkd...eyddyfee.....lfekkaeaepkyqsesgdwlnltvpdteanvi 158
                  eg+ f   +g+++D++++++fD+k+f++ + + +      slle+++k +   +y++y+++      f++k+e++                    ++i
  EFC36284.1 618 -EGGwFqmrLGVSSDCAVVGLFDQKYFNDENVLPAskvrqkSLLEANFKLCyepPYQEYLTKkmeeeGFPDKMEMP--------------------YGI 695
                 .6665899*************************9999999999999999999999999999933333333333333....................9** PP

     DUF4241 159 ifssGfGDGaYpvyfgydedgevvalvi 186
                 i+ssG+GDG+Yp++f+++e+g+v+a++i
  EFC36284.1 696 ITSSGYGDGYYPTLFKKSEKGDVIAVKI 723
                 *************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (726 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       520  (0.0290033); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 4351.29
//
Query:       EFC36285.1  [L=777]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (777 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.29s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 4725.83
//
Query:       EFC36286.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-29   99.6  23.4    3.1e-07   30.0   0.2    5.5  5  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    1.7e-21   76.6   4.3    9.1e-05   23.0   0.0    6.8  6  RCC1      Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.0   4.7e-10   4.2e-06       1      30 []     103     132 ..     103     132 .. 0.98
   2 !   26.7   4.0   3.8e-10   3.4e-06       2      30 .]     160     188 ..     159     188 .. 0.97
   3 !    8.9   0.0   0.00014       1.3       5      21 ..     212     228 ..     208     231 .. 0.89
   4 !   30.0   0.2   3.4e-11   3.1e-07       2      30 .]     311     339 ..     311     339 .. 0.96
   5 !   18.4   1.2   1.5e-07    0.0013       3      30 .]     404     431 ..     402     431 .. 0.92

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 4.7e-10
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++++G+ H++ Lt+ G++l++G N dGQ
  EFC36286.1 103 IVKIASGGHHTVLLTSLGRILSFGKNLDGQ 132
                 799**************************9 PP

  == domain 2  score: 26.7 bits;  conditional E-value: 3.8e-10
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++v++G++H+++Lt+ G+++++G+N +GQ
  EFC36286.1 160 VDVCCGNNHTVILTNLGNLMGCGWNAYGQ 188
                 79**************************9 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.00014
      RCC1_2   5 saGdyHscaLtedGeVl 21 
                  aG++ +c+L++dG+++
  EFC36286.1 212 RAGNNATCILDADGRLY 228
                 59*************98 PP

  == domain 4  score: 30.0 bits;  conditional E-value: 3.4e-11
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ks s G yH ++Lt +G+++++G N++GQ
  EFC36286.1 311 KSFSVGLYHCLFLTHSGRMYATGYNGYGQ 339
                 6789************************9 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 1.5e-07
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 s+ aG++Hs+++++ G+++++G N +GQ
  EFC36286.1 404 SILAGSCHSLFVSNLGTIYGCGYNAYGQ 431
                 6669***********************9 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0   0.00044       3.9      29      50 .]      97     116 ..      90     116 .. 0.85
   2 !   22.4   0.0   1.5e-08   0.00014       2      50 .]     120     172 ..     120     172 .. 0.79
   3 !    8.3   0.0    0.0004       3.5       2      23 ..     176     197 ..     176     221 .. 0.65
   4 !   23.0   0.0     1e-08   9.1e-05       1      32 [.     326     357 ..     326     369 .. 0.90
   5 ?    0.1   0.0      0.14   1.3e+03      33      50 .]     397     415 ..     390     415 .. 0.78
   6 !    8.4   0.0   0.00037       3.4       2      15 ..     419     432 ..     419     456 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00044
                 -GGGTTS-EEEEEEETTEEEEE CS
        RCC1  29 veglsgnrvvkvacGddhtval 50 
                 v+g++   +vk+a+G++htv+l
  EFC36286.1  97 VQGSE--YIVKIASGGHHTVLL 116
                 55665..89**********986 PP

  == domain 2  score: 22.4 bits;  conditional E-value: 1.5e-08
                 TEEEEEE--GGGTTSSSS-..--E....EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt..esv....lvPtkveglsgnrvvkvacGddhtval 50 
                 Gr++s+G+n +Gq G +t+  +s+     +P    + +   +v+v+cG++htv l
  EFC36286.1 120 GRILSFGKNLDGQVGWKTElnHSNdigeAKPLYKYTNE--FAVDVCCGNNHTVIL 172
                 9******************7655555555594443333..9***********976 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0004
                 TEEEEEE--GGGTTSSSS---E CS
        RCC1   2 GrVysWGrndyGqLGlgttesv 23 
                 G++ ++G+n yGqL  g++ s+
  EFC36286.1 176 GNLMGCGWNAYGQLAEGPHSSQ 197
                 666789**********999655 PP

  == domain 4  score: 23.0 bits;  conditional E-value: 1e-08
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGG CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkvegl 32 
                 +Gr y+ G n yGqLG+g+ ++ ++P++++ +
  EFC36286.1 326 SGRMYATGYNGYGQLGTGDFQDLNTPKEITKF 357
                 69*************************99765 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.14
                 TTS.-EEEEEEETTEEEEE CS
        RCC1  33 sgn.rvvkvacGddhtval 50 
                 ++n  ++++ +G+ h++++
  EFC36286.1 397 EKNeFITSILAGSCHSLFV 415
                 55557899********985 PP

  == domain 6  score: 8.4 bits;  conditional E-value: 0.00037
                 TEEEEEE--GGGTT CS
        RCC1   2 GrVysWGrndyGqL 15 
                 G +y++G n yGqL
  EFC36286.1 419 GTIYGCGYNAYGQL 432
                 89***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       702  (0.0391544); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 3096.27
//
Query:       EFC36287.1  [L=369]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-34  113.0  27.5     0.0041   17.0   0.1   11.9 12  LRR_6     Leucine Rich repeat
    1.4e-25   88.8  27.7    1.6e-07   31.0   0.1    6.6  6  LRR_8     Leucine rich repeat
    1.3e-20   73.1  43.3    6.1e-05   23.3   1.0    9.4 11  LRR_4     Leucine Rich repeats (2 copies)
    2.8e-13   48.4  18.0        4.5    8.2   0.2   11.5 12  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.5   6.8e+03      13      21 ..      33      41 ..      27      44 .. 0.71
   2 !   14.7   0.0   5.3e-06     0.024       4      22 ..      48      66 ..      46      67 .. 0.89
   3 !   16.5   0.0   1.4e-06    0.0061       3      24 .]      95     116 ..      93     116 .. 0.92
   4 !   10.9   0.2   8.7e-05      0.39       3      21 ..     119     137 ..     117     139 .. 0.88
   5 !   15.7   0.2   2.5e-06     0.011       3      20 ..     143     160 ..     141     164 .. 0.88
   6 !    8.1   0.0   0.00069       3.1       5      24 .]     169     188 ..     166     188 .. 0.93
   7 !    8.1   0.2   0.00068       3.1       3      22 ..     191     210 ..     189     211 .. 0.88
   8 ?    0.9   0.1      0.14   6.3e+02       3      11 ..     215     223 ..     213     224 .. 0.83
   9 !   10.3   0.0   0.00014      0.61       3      18 ..     242     257 ..     240     257 .. 0.89
  10 !   17.0   0.1   9.2e-07    0.0041       4      23 ..     267     286 ..     264     286 .. 0.92
  11 !   15.8   0.1   2.4e-06     0.011       3      21 ..     290     308 ..     288     308 .. 0.92
  12 !    4.5   0.0    0.0099        44       4      16 ..     339     351 ..     336     359 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.5
       LRR_6 13 NdIgDeGae 21
                N+I+D  + 
  EFC36287.1 33 NGIQDNDMR 41
                788887665 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 5.3e-06
       LRR_6  4 hLteLdLsgNdIgDeGaea 22
                 LteLd+  +dI++eG++ 
  EFC36287.1 48 QLTELDIERCDISGEGIKF 66
                69**************985 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 1.4e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+Ld++ N+Ig eGa+ ++
  EFC36287.1  95 SKLTKLDINTNEIGTEGAKYIS 116
                 79****************9885 PP

  == domain 4  score: 10.9 bits;  conditional E-value: 8.7e-05
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 + LteLd+  N+I  eGa+
  EFC36287.1 119 NQLTELDIGNNNILSEGAK 137
                 579**************98 PP

  == domain 5  score: 15.7 bits;  conditional E-value: 2.5e-06
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                  +L +L++  N+IgDeGa
  EFC36287.1 143 KNLVKLNVERNNIGDEGA 160
                 5899*************8 PP

  == domain 6  score: 8.1 bits;  conditional E-value: 0.00069
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+ +N +g eG++a++
  EFC36287.1 169 LTALDIGFNMFGFEGIKAIS 188
                 9*****************96 PP

  == domain 7  score: 8.1 bits;  conditional E-value: 0.00068
       LRR_6   3 thLteLdLsgNdIgDeGaea 22 
                 +hL eL+++gN+I+  G++ 
  EFC36287.1 191 NHLIELSIQGNEITINGVKL 210
                 8*************999986 PP

  == domain 8  score: 0.9 bits;  conditional E-value: 0.14
       LRR_6   3 thLteLdLs 11 
                  +Lt+L+L 
  EFC36287.1 215 KNLTSLNLG 223
                 68*****96 PP

  == domain 9  score: 10.3 bits;  conditional E-value: 0.00014
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 + Lt+Ld+  N+Ig e
  EFC36287.1 242 HQLTTLDIENNNIGPE 257
                 67************87 PP

  == domain 10  score: 17.0 bits;  conditional E-value: 9.2e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +L++L++++N+I  eG++ +
  EFC36287.1 267 NLKHLNIAFNNIEKEGLSHI 286
                 8****************976 PP

  == domain 11  score: 15.8 bits;  conditional E-value: 2.4e-06
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 t Lt+L++ gN+I+DeGa+
  EFC36287.1 290 TQLTSLNVCGNQIDDEGAK 308
                 78***************96 PP

  == domain 12  score: 4.5 bits;  conditional E-value: 0.0099
       LRR_6   4 hLteLdLsgNdIg 16 
                  Lt L +s+N Ig
  EFC36287.1 339 QLTQLYISSNRIG 351
                 69**********9 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.1    0.0057        26      24      58 ..       1      34 [.       1      36 [. 0.86
   2 !   15.0   0.0   3.5e-06     0.016       1      61 []      47     107 ..      47     107 .. 0.96
   3 !   28.9   1.0   1.6e-10   7.2e-07       2      60 ..     120     178 ..     119     179 .. 0.97
   4 !   12.4   1.6   2.3e-05       0.1       2      57 ..     168     223 ..     168     224 .. 0.94
   5 !   15.4   2.0   2.6e-06     0.012      22      61 .]     239     278 ..     234     278 .. 0.89
   6 !   31.0   0.1   3.6e-11   1.6e-07       2      61 .]     291     350 ..     290     350 .. 0.98

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0057
                -TT--EEE--SS.---GGGGGGGTT--S-.EEE--S CS
       LRR_8 24 lsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsg 58
                +++L++L L  N + +++  +a+s +++L++L ++g
  EFC36287.1  1 MERLNELTLETNdTSSSI--EAISEMRQLTKLGING 34
                57899*******777778..5***********9875 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 3.5e-06
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++Lt+Ld+ +  +++ + ++   +++L++L+ ++N l+  +++ +s +++L++Ld++ N +
  EFC36287.1  47 SQLTELDIERCDISGEGIKFLIVMPQLTSLNGGYNYLQCGDAKLISEMSKLTKLDINTNEI 107
                 5899*****************************************************9986 PP

  == domain 3  score: 28.9 bits;  conditional E-value: 1.6e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+Ld+ nN++ s + ++ ++l+nL  L+  +N++    ++ +s +++L+ Ld+  N 
  EFC36287.1 120 QLTELDIGNNNILSEGAKFIRNLKNLVKLNVERNNIGDEGANYISEMKQLTALDIGFNM 178
                 79*****************************************************9995 PP

  == domain 4  score: 12.4 bits;  conditional E-value: 2.3e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 +Lt Ld+ +N +   + +a ++l++L +L++  N++t    + +   ++L+sL+L 
  EFC36287.1 168 QLTALDIGFNMFGFEGIKAISQLNHLIELSIQGNEITINGVKLITEKKNLTSLNLG 223
                 5999**********************************9999***********996 PP

  == domain 5  score: 15.4 bits;  conditional E-value: 2.6e-06
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +++++L++Ld+ nN++    ++ ++ +++L++L++  N++
  EFC36287.1 239 SQMHQLTTLDIENNNIGPEVANLLAEMKNLKHLNIAFNNI 278
                 56899999******99997799************999997 PP

  == domain 6  score: 31.0 bits;  conditional E-value: 3.6e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL+++ N++ + + +  +++++L  L++ +N l+    +++  +p+L++L++s+Nr+
  EFC36287.1 291 QLTSLNVCGNQIDDEGAKIVSSMKQLLKLNIEENFLNEGGCETIIEMPQLTQLYISSNRI 350
                 8*********************************************************98 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1      0.91   4.1e+03      23      39 ..       2      18 ..       1      23 [. 0.68
   2 !    9.3   0.0   0.00034       1.5       2      40 ..      26      60 ..      25      65 .. 0.82
   3 ?   -0.6   0.0      0.46   2.1e+03      19      29 ..      67      77 ..      59      85 .. 0.77
   4 !    6.2   0.5    0.0034        15      20      36 ..      91     107 ..      71     119 .. 0.70
   5 !   18.2   3.4   5.6e-07    0.0025       2      36 ..     120     155 ..     119     159 .. 0.86
   6 !   11.0   0.2   9.9e-05      0.44       1      33 [.     143     177 ..     143     192 .. 0.84
   7 !   13.0   2.2   2.4e-05      0.11       2      34 ..     192     225 ..     191     236 .. 0.79
   8 !   23.3   2.5   1.4e-08   6.2e-05       2      36 ..     243     278 ..     242     288 .. 0.85
   9 !   23.3   1.0   1.4e-08   6.1e-05       1      38 [.     266     304 ..     266     308 .. 0.88
  10 !   13.7   0.8   1.4e-05     0.065       1      36 [.     290     326 ..     290     328 .. 0.85
  11 !    7.5   0.0    0.0013       5.9      22      36 ..     337     350 ..     330     355 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.91
                TT--EEE-.-S-----G CS
       LRR_4 23 pnLkeLdLsgNnlitdl 39
                  L eL+L  N   +++
  EFC36287.1  2 ERLNELTLETNDTSSSI 18
                67999999888555555 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00034
                S--EEE--SS---E-S-HH..H-TT--EEE-.-S-----GG CS
       LRR_4  2 nLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitdld 40
                +L++L +++  ++d +  +   + +L+eLd+ ++    d++
  EFC36287.1 26 QLTKLGING--IQDNDMRQigMMSQLTELDIERC----DIS 60
                578888888..***99955526*********999....886 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.46
                HHH-TT--EEE CS
       LRR_4 19 leklpnLkeLd 29
                l  +p+L++L+
  EFC36287.1 67 LIVMPQLTSLN 77
                44499999997 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0034
                 HH.-TT--EEE-.-S--- CS
       LRR_4  20 ek.lpnLkeLdLsgNnli 36 
                  + + +L++Ld++ N  i
  EFC36287.1  91 ISeMSKLTKLDINTN-EI 107
                 3339********666.55 PP

  == domain 5  score: 18.2 bits;  conditional E-value: 5.6e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++Ld++nN++ + +   +++l+nL +L++ +N +i
  EFC36287.1 120 QLTELDIGNNNILSEGAkfIRNLKNLVKLNVERN-NI 155
                 69*********99988897779*********888.45 PP

  == domain 6  score: 11.0 bits;  conditional E-value: 9.9e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 +nL +L+   N++ d +   ++ +++L+ Ld+ +N
  EFC36287.1 143 KNLVKLNVERNNIGDEGAnyISEMKQLTALDIGFN 177
                 69*************99986445*********555 PP

  == domain 7  score: 13.0 bits;  conditional E-value: 2.4e-05
                 S--EEE--SS---E-S-..HH.H-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl..le.klpnLkeLdLsgNn 34 
                 +L++L++++N +t i++  l    +nL++L+L gN 
  EFC36287.1 192 HLIELSIQGNEIT-INGvkLItEKKNLTSLNL-GNI 225
                 69***********.5554855358********.994 PP

  == domain 8  score: 23.3 bits;  conditional E-value: 1.4e-08
                 S--EEE--SS---.E-S-.HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqlt.dipl.leklpnLkeLdLsgNnli 36 
                 +L++Ld+ nN++  ++ + l+ ++nLk+L++ +N +i
  EFC36287.1 243 QLTTLDIENNNIGpEVANlLAEMKNLKHLNIAFN-NI 278
                 7************999996667*********777.55 PP

  == domain 9  score: 23.3 bits;  conditional E-value: 1.4e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +nL++L+++ N++ + +l  + +l++L++L++ gN +i+d
  EFC36287.1 266 KNLKHLNIAFNNIEKEGLshITQLTQLTSLNVCGN-QIDD 304
                 79************988866669********9899.8865 PP

  == domain 10  score: 13.7 bits;  conditional E-value: 1.4e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L+  +Nq+ d +  + + +++L +L++ +N ++
  EFC36287.1 290 TQLTSLNVCGNQIDDEGAkIVSsMKQLLKLNIEEN-FL 326
                 68*************99985544*********888.54 PP

  == domain 11  score: 7.5 bits;  conditional E-value: 0.0013
                 -TT--EEE-.-S--- CS
       LRR_4  22 lpnLkeLdLsgNnli 36 
                 +p+L++L++s+N +i
  EFC36287.1 337 MPQLTQLYISSN-RI 350
                 899999999888.55 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0    0.0037        17       1      16 [.      48      63 ..      48      77 .. 0.83
   2 ?    2.0   0.0      0.11   4.7e+02       1      18 [.      96     113 ..      96     118 .. 0.76
   3 !    7.7   0.1    0.0015       6.6       1      22 [.     120     141 ..     120     142 .. 0.80
   4 !    6.4   0.0    0.0039        18       1      21 [.     144     164 ..     144     166 .. 0.90
   5 ?    0.7   0.0       0.3   1.4e+03       2      13 ..     169     180 ..     168     190 .. 0.73
   6 ?   -0.6   0.0      0.76   3.4e+03       1      12 [.     192     203 ..     192     210 .. 0.83
   7 ?    1.5   0.1      0.16   7.3e+02       1       9 [.     216     224 ..     216     237 .. 0.85
   8 !    6.6   0.0    0.0034        15       1      13 [.     243     255 ..     243     263 .. 0.79
   9 !    8.2   0.2     0.001       4.5       1      17 [.     267     283 ..     267     289 .. 0.77
  10 ?    4.1   0.0     0.022        99       1      16 [.     291     306 ..     291     313 .. 0.80
  11 ?    0.4   0.1      0.37   1.7e+03       2      12 ..     316     326 ..     315     335 .. 0.77
  12 ?    2.8   0.0      0.06   2.7e+02       2      17 ..     340     355 ..     339     362 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0037
       LRR_1  1 nLrhLdLsnnpllglp 16
                +L++Ld++++ ++g +
  EFC36287.1 48 QLTELDIERCDISGEG 63
                599********96655 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld++ n ++  ++ 
  EFC36287.1  96 KLTKLDINTNEIGTEGAK 113
                 79*****99998666655 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0015
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++Ld++nn++l+ ++  + n
  EFC36287.1 120 QLTELDIGNNNILSEGAKFIRN 141
                 599********98877776665 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.0039
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL +L++++n++++ ++n+++
  EFC36287.1 144 NLVKLNVERNNIGDEGANYIS 164
                 899*********999999987 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.3
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ Ld++ n ++
  EFC36287.1 169 LTALDIGFNMFG 180
                 899*****9874 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.76
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L +L + +n +
  EFC36287.1 192 HLIELSIQGNEI 203
                 5899*****987 PP

  == domain 7  score: 1.5 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsn 9  
                 nL++L+L+n
  EFC36287.1 216 NLTSLNLGN 224
                 8******76 PP

  == domain 8  score: 6.6 bits;  conditional E-value: 0.0034
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld++nn+++
  EFC36287.1 243 QLTTLDIENNNIG 255
                 599*******983 PP

  == domain 9  score: 8.2 bits;  conditional E-value: 0.001
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL+hL++  n+++  + 
  EFC36287.1 267 NLKHLNIAFNNIEKEGL 283
                 8**********965544 PP

  == domain 10  score: 4.1 bits;  conditional E-value: 0.022
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L++++n++++ +
  EFC36287.1 291 QLTSLNVCGNQIDDEG 306
                 599*******997655 PP

  == domain 11  score: 0.4 bits;  conditional E-value: 0.37
       LRR_1   2 LrhLdLsnnpl 12 
                 L +L+++ n+l
  EFC36287.1 316 LLKLNIEENFL 326
                 668******98 PP

  == domain 12  score: 2.8 bits;  conditional E-value: 0.06
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L+ L++s+n+++ ++ 
  EFC36287.1 340 LTQLYISSNRIGEKQV 355
                 899*******976665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (369 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.41u 0.24s 00:00:00.64 Elapsed: 00:00:00.37
# Mc/sec: 2958.91
//
Query:       EFC36288.1  [L=380]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (380 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       534  (0.0297841); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.45
# Mc/sec: 2546.08
//
Query:       EFC36289.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.097   12.5   0.0       0.79    9.6   0.0    2.5  2  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
       0.15   12.2   0.2        0.7   10.0   0.0    2.2  2  DUF5500   Family of unknown function (DUF5500)


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.14   1.3e+03      13      21 ..      53      61 ..      53      63 .. 0.87
   2 ?    9.6   0.0   8.9e-05      0.79       1      30 []     207     236 ..     207     236 .. 0.96

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.14
      RCC1_2 13 aLtedGeVl 21
                +L+e+G V+
  EFC36289.1 53 VLSESGQVY 61
                799*****9 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 8.9e-05
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +k++ +G++ ++++ ed++V+ +G+N++ Q
  EFC36289.1 207 IKKIECGSFQFFVIFEDDTVMFCGDNGSNQ 236
                 799***********************9988 PP

>> DUF5500  Family of unknown function (DUF5500)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   7.8e-05       0.7      24      59 ..     147     182 ..     133     194 .. 0.88
   2 ?   -2.0   0.0      0.42   3.8e+03      41      53 ..     329     341 ..     317     348 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 7.8e-05
     DUF5500  24 fltrrtrdgfcgrltsiatnshytmfvldhgsvrie 59 
                 + t  t +g+  ++t ia+   +t++vld+  +ri 
  EFC36289.1 147 LYTPPTVNGYRHQITHIASCYSFTIIVLDYCDIRIS 182
                 56778999**************************96 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.42
     DUF5500  41 atnshytmfvldh 53 
                  +nsh   fv+d 
  EFC36289.1 329 ISNSHNMRFVVDA 341
                 479***99**996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2463.25
//
Query:       EFC36290.1  [L=156]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-05   23.3   0.2     0.0001   22.4   0.2    1.6  1  Erf4      Golgin subfamily A member 7/ERF4 family
  ------ inclusion threshold ------
      0.029   14.8   0.3      0.036   14.5   0.3    1.1  1  MerC      MerC mercury resistance protein
       0.93    9.9   3.9         16    6.0   0.1    2.6  3  DUF3624   Protein of unknown function (DUF3624)


Domain annotation for each model (and alignments):
>> Erf4  Golgin subfamily A member 7/ERF4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.2   1.7e-08    0.0001      14      75 ..      11      73 ..       6     129 .. 0.88

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 1.7e-08
        Erf4 14 apqFstllppeLsgyiseeefeeiinkiNeilaeafspysvrnil.dnvlglltlylwslvlk 75
                a qF +++p++ s+++ +e+f++ +++iN+  ++   p+++++i   +++ + +l+l++ v+ 
  EFC36290.1 11 AKQFTSEFPSQFSSILAPETFDSHLEQINKCAIKHVGPITIQTISvSTLVTINSLALMAAVSG 73
                68****************************************996145566667777777766 PP

>> MerC  MerC mercury resistance protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.3     6e-06     0.036      33      85 ..      55     116 ..      42     146 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6e-06
        MerC  33 lasellhqvllilvvaigllalvvgyrrhrktsvlvlgalGllillvalflg.........t 85 
                 + s l+    l+l++a++++++++ y + +  +v  l+a+G+ +ll+a+ +          +
  EFC36290.1  55 SVSTLVTINSLALMAAVSGFSTLKKYDTSQPILVGSLLAIGISLLLIAHSIAlilmsikykQ 116
                 557778888999************************************99885555544441 PP

>> DUF3624  Protein of unknown function (DUF3624)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.1    0.0026        16      42      62 ..      57      77 ..      39      80 .. 0.86
   2 ?    4.6   0.4    0.0072        43      54      74 ..      91     111 ..      83     113 .. 0.83
   3 ?   -2.8   0.0       1.5   8.8e+03       7      15 ..     136     144 ..     134     145 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0026
     DUF3624 42 dtpksvesialllaafafsgL 62
                 t  +++s+al+ a+++fs+L
  EFC36290.1 57 STLVTINSLALMAAVSGFSTL 77
                67789*************998 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0072
     DUF3624  54 laafafsgLLllHlvvlayrk 74 
                 l a+++s+LL++H ++l++ +
  EFC36290.1  91 LLAIGISLLLIAHSIALILMS 111
                 678999*******99988765 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 1.5
     DUF3624   7 kesvfkkKl 15 
                 ++s+f +K+
  EFC36290.1 136 ENSWFSQKI 144
                 689999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       943  (0.0525964); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.39u 0.25s 00:00:00.64 Elapsed: 00:00:00.41
# Mc/sec: 1143.25
//
Query:       EFC36291.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0038   15.4  18.3     0.0046   15.1  18.3    1.1  1  AF-4      AF-4 proto-oncoprotein
  ------ inclusion threshold ------
       0.38    9.4   2.2        0.4    9.3   2.2    1.1  1  Ndc1_Nup  Nucleoporin protein Ndc1-Nup
        4.7    5.9  10.0        6.2    5.5  10.0    1.1  1  DUF4551   Protein of unknown function (DUF4551)


Domain annotation for each model (and alignments):
>> AF-4  AF-4 proto-oncoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1  18.3   7.7e-07    0.0046     786     943 ..      39     188 ..      18     264 .. 0.58

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 7.7e-07
        AF-4 786 PqrpekesqskkaesksepeegkkkeskqkskkssskskrkrKs....eeeaenksdskklrleketksllsppviss....shkesskkksskkksee 876
                 P + +k   skk++s  e++egk+++++++ k sss+ ++k+ +    e      ++   +  e+e  s+++ +v+ +     +ke s+kk +++ s+e
  EFC36291.1  39 PIQVTK-VGSKKKSSPIEKKEGKSSRENRSGKASSSRRNQKEEEelsiE------EEDDVFSEEDEIISSKLGKVSKKkpssGSKEVSEKK-PSSGSKE 129
                 444444.334444444455555555444444444444444444333211......122222222222222222222221111444444443.3334444 PP

        AF-4 877 kkkekllppllsplsseskskkpakkrsssessslsqessksaketkssskkssssskhkksegkas 943
                 kkk+k+  p+     + ++s+k++ kr+++++ +l +e+s  +  + +s+++ + s+k+kk++g+  
  EFC36291.1 130 KKKKKTIAPS-----NVPPSSKTSIKRKNQQEGELAKEGS--DGIQFDSEES-EPSQKKKKKDGELE 188
                 4444444444.....4455555566888888889998887..3333344444.45566666555543 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   2.2   6.6e-05       0.4     363     452 ..      62     171 ..      40     325 .. 0.55

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 6.6e-05
    Ndc1_Nup 363 s......kapknkasapvkelprlsksplkkk.......ddeifgn.......sltaeaspkssssskegvekalsslakspgqs....psptarlspr 437
                 s      k              ++s+ ++k++       +d++f +       +l + +++k+ss ske  ek+ ss +k+ +++    p   +++ p+
  EFC36291.1  62 SrenrsgK-------------ASSSRRNQKEEeelsieeEDDVFSEedeiissKLGKVSKKKPSSGSKEVSEKKPSSGSKEKKKKktiaP---SNVPPS 144
                 02222111.............111122222222233333333444444444322222233333333444444444444444433342332...222233 PP

    Ndc1_Nup 438 arkllekaksrlls............k 452
                 ++  +++++++  +            +
  EFC36291.1 145 SKTSIKRKNQQEGElakegsdgiqfdS 171
                 333333222222222224444443331 PP

>> DUF4551  Protein of unknown function (DUF4551)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5  10.0     0.001       6.2     114     257 ..      47     192 ..      29     232 .. 0.37

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.001
     DUF4551 114 kkselfkvspskasekksrressgaakkssslnessldakekeektvskksqlslslselrklseeekeelesekalkslrsasrplPesllsrapkpp 212
                 +k++++++++++ +++ ++r+ +++++  ++ +e++l+ +  ee  v+++    +s s+l k+s+++  +  +e + k+ +s s  + ++ ++  ++ p
  EFC36291.1  47 SKKKSSPIEKKEGKSSRENRSGKASSSRRNQKEEEELSIE--EEDDVFSEEDEIIS-SKLGKVSKKKPSSGSKEVSEKKPSSGSKEKKKKKTIAPSNVP 142
                 3333334443333222222222211111111122222222..22222222222222.333333333333322222222222222222222222222222 PP

     DUF4551 213 sspkeppssslskderdskseess.......qvelrlgsvlsrlllrslats 257
                 +s+k++ +++++++ +   +e s+       ++e +++   +   l +++ +
  EFC36291.1 143 PSSKTSIKRKNQQEGE-LAKEGSDgiqfdseESEPSQKKKKKDGELEDWR-K 192
                 2222222222222222.222222222221113333333334444444444.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1414  (0.0788666); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.35s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 2161.24
//
Query:       EFC36292.1  [L=945]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.1e-05   21.7   0.1     0.0006   19.0   0.1    2.0  2  MGAT2     N-acetylglucosaminyltransferase II (MGAT2)
    0.00014   20.7   0.3    0.00033   19.6   0.3    1.5  1  GNT-I     GNT-I family


Domain annotation for each model (and alignments):
>> MGAT2  N-acetylglucosaminyltransferase II (MGAT2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.1   6.7e-08    0.0006       6      83 ..     626     702 ..     623     720 .. 0.80
   2 ?   -0.1   0.0     0.042   3.8e+02     157     193 ..     747     783 ..     742     809 .. 0.74

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 6.7e-08
       MGAT2   6 eaNekqevlnedkfgk.lakdelvivvqvhnrleylrlliesLekakgieeallvfshdvyseeinelvqsidFcrvlq 83 
                 e+N+ + vln+dkf + +++d+l i ++ ++r++ l+ ++e + k+++ie+++l+++ d   e   +++++i  ++ ++
  EFC36292.1 626 EMNNLNFVLNSDKFDEsQQEDHLPIWLRAYKRTSPLKEVLEGVCKVRDIEKSILIITIDG--EAFLSVLSEILLVKCVK 702
                 5778899*******983566788899*******************************996..44555555555555544 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.042
       MGAT2 157 lkeykglvlflEedhyvapdflhvlklleklkkeecp 193
                 +k+   +v+ lE+d + ++df+++ + l k++ +e +
  EFC36292.1 747 VKYKYPYVITLEDDIIPFSDFYNYHRSLYKHTINEAS 783
                 67778899***************99999887766543 PP

>> GNT-I  GNT-I family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.3   3.7e-08   0.00033      63     249 ..     615     807 ..     564     814 .. 0.71

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 3.7e-08
       GNT-I  63 rldeelsklralvktve.kkeiakldlkqakdviavlvlacsradavrrtvekllkyrpsaekfPlivsqdcsn.eevkkevlsy.gdkvt.yikhl.. 155
                 ++d  l++ + ++++++   +  k d +q++d +++ + a +r++ +++ +e + k r   ek  li++ d++    v +e+l     k+  y++    
  EFC36292.1 615 NMDRTLEDWKVEMNNLNfVLNSDKFDESQQEDHLPIWLRAYKRTSPLKEVLEGVCKVRDI-EKSILIITIDGEAfLSVLSEILLVkCVKIRiYFHAFkn 712
                 555555555555555431345678889999999999999999999999999999999976.66778999999873467776654412333313333333 PP

       GNT-I 156 dlesiavePderklta..yykiarhyklaldqvfvkkkfsrviileddleiapdffdyfeatasl.ldrdksllavsaWndnGkkqfvdasapealy 249
                  l++++ +  +  +t     k+  h  + l   fvk+k++ vi ledd+   +df++y ++ ++  +++    +a+s++   G  ++    +++aly
  EFC36292.1 713 SLQNLMGPNFDNAFTQekSTKLLTHALYGLYLCFVKYKYPYVITLEDDIIPFSDFYNYHRSLYKHtINEASPYFAISSYA-HGMTHNCRY-TASALY 807
                 556666664444555411568999999999*******************************8865156666678888886.466666665.456666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (945 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.78u 0.34s 00:00:01.12 Elapsed: 00:00:00.51
# Mc/sec: 5557.95
//
Query:       EFC36293.1  [L=538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.5e-31  109.7   1.4    4.1e-28   98.4   0.0    2.8  3  LBP_BPI_CETP_C  LBP / BPI / CETP family, C-terminal domain
    3.2e-11   43.1   0.4      1e-10   41.5   0.4    1.9  1  LBP_BPI_CETP    LBP / BPI / CETP family, N-terminal domain


Domain annotation for each model (and alignments):
>> LBP_BPI_CETP_C  LBP / BPI / CETP family, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.1   7.1e-05      0.63     180     214 ..      72     105 ..      11     107 .. 0.84
   2 ?   -2.6   0.0      0.34     3e+03     186     208 ..     232     253 ..     220     270 .. 0.61
   3 !   98.4   0.0   4.6e-32   4.1e-28       9     238 .]     289     519 ..     258     519 .. 0.94

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 7.1e-05
                     -GGGGHHHHHHHHHHHCHHHHHHHHHH-EE----T CS
  LBP_BPI_CETP_C 180 sveslqalLnymitelleplvneklqkgfplplpk 214
                        + q  Lnym ++ ++pl+++kl  gf +p+ +
      EFC36293.1  72 TISIQQRSLNYM-AQQFMPLIQQKLSSGFNIPDIH 105
                     55677888*965.55679**************875 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.34
                     HHHHHHHHHHCHHHHHHHHHH-E CS
  LBP_BPI_CETP_C 186 alLnymitelleplvneklqkgf 208
                      + n m+t  l + +ne + k +
      EFC36293.1 232 NVTN-MVTSQLTKSLNEVITKAL 253
                     3333.666666666666665554 PP

  == domain 3  score: 98.4 bits;  conditional E-value: 4.6e-32
                     -EEEESSS----SS-----------SSSEEEEEEHHHHHHHHHHHHHTT-SEEEEEGGGS-TT-S--SBHHHHCTTSTTHHHHSTT-BEEEEEEE CS
  LBP_BPI_CETP_C   9 GeffpknhrspvrtlppvealpeesdrMvylaiSdylfnslllvayragfLkltltddmlpassdlrlttkcfgeflpelaeqfPnrqlelevsa 103
                     G ff+k+  + +  ++++ + + +sd+M++++i+ y+ n++ +++ +a  L++ +t+  +p++ + + +t + + ++p l     n +++l ++ 
      EFC36293.1 289 GMFFNKGGNVYNGQPTTMLETL-GSDKMIEIFIDQYVLNTAGFASSQANILNTVVTSANIPKNFGWLFNTSSYSSLVPSLYSLCNNCEIQLDITD 382
                     8999999777777777766666.********************************************99999999******************** PP

                     SS--EEEEETT.EEEEE-EEEEEEEEE-TTS-EEEEEEEEEE--EEEEEEEETTEEEEEEEE---EEEEEEETT----GGGGHHHHHHHHHHHCH CS
  LBP_BPI_CETP_C 104 lkaPlislspk.gltvslslsvnvfvvlPnqqkeqvltldvdtnasvtlsingkkvvgslkleklqlklkeskvgefsveslqalLnymitelle 197
                      +aP  ++ ++ gl ++ ++s  + ++ P++    ++ l++++ ++   ++++++++   + +++ + l+ s++g+fsv  l+++++ +i   ++
      EFC36293.1 383 ATAPTANIDTQiGLELDAQASAIFQIIKPDKTIVNAFALKIEMAFDTLPTLQNNNLTFAFTYKNASISLQYSNIGQFSVGFLSDAIKAVIEFGVI 477
                     ***********9*********************************************************************************** PP

                     HHHHHHH.HH-EE----TTEEEEEEEEEEETTEEEEEEEEEE CS
  LBP_BPI_CETP_C 198 plvnekl.qkgfplplpkglqlkdlklqihdrfLllgadvkl 238
                     p  n  + qkg+plp +kgl l ++ + i d+++ l  d+ +
      EFC36293.1 478 PIANMFIgQKGVPLPVMKGLTLNNPAMVIEDGYICLRSDFTF 519
                     ***9988589**************************999975 PP

>> LBP_BPI_CETP  LBP / BPI / CETP family, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.5   0.4   1.1e-14     1e-10       2     162 ..      80     246 ..      79     255 .. 0.84

  Alignments for each domain:
  == domain 1  score: 41.5 bits;  conditional E-value: 1.1e-14
                   HHHHCHHHHHHHHHHHH.TS-CCCEEEEEEETTTECEEEEEEEEEEEEEEEEEEEEEEETTTEEEEEEEEEEEEEEEEEEECE.CCEEE......EE CS
  LBP_BPI_CETP   2 Ldyakqeglkvlqkele.klqlpdilgeekikllgkvkynisnlkIsnlqlpslslklspggglllliiplslkisgklpllg.sflel......av 90 
                   L+y +q+ +  +q++l    ++pdi +e  ++ +gkv+ + +n++Is ++l++  l    +g+ll++  ++ ++++ ++++ +  f+        + 
    EFC36293.1  80 LNYMAQQFMPLIQQKLSsGFNIPDIHTEDHTP-IGKVELSATNIQISGVSLATPVLTI-GNGELLVNLPSAHADMHCNWKYDKkHFVSDhgsadaHI 174
                   88999999999999886258*****9999966.8******************998865.5666688888999**********845555588886677 PP

                   EEEEEEEEEEEEETTSEEEEEEEEEEEEEEEEEEEETTCGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  LBP_BPI_CETP  91 gvsitaelalerdeqGrprlvlseCsssigsislsllgglgslldlltnllektlkkvlesqlCpviqsvLs 162
                    + i++ l +   +  +  +++ + + ++++ +l+l gg+++l++++++ ++ ++  ++ +++   +++ L+
    EFC36293.1 175 TIAISLGLQISVLSPTQFGVTVNNVQAHFSQFDLKLHGGASWLYNFFIKNFKHHIEDNVTNMVTSQLTKSLN 246
                   7777777777666667899******************************************98887755554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       778  (0.0433934); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 3393.10
//
Query:       EFC36294.1  [L=566]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-24   82.8  15.4    3.9e-07   29.7   0.0    8.3  8  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.046   14.2   1.0       0.11   12.9   1.0    1.6  1  HTH_44    Helix-turn-helix DNA-binding domain of SPT6


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.1    0.0014        13       3      35 ..     120     149 ..     118     167 .. 0.80
   2 !    8.5   0.1   0.00018       1.6       1      45 [.     140     190 ..     140     193 .. 0.67
   3 !   22.3   0.0   8.7e-09   7.8e-05       1      46 [.     195     242 ..     195     246 .. 0.90
   4 !   13.0   1.0   6.9e-06     0.062      16      39 ..     264     287 ..     247     303 .. 0.75
   5 !   16.4   0.1   6.3e-07    0.0057       1      49 []     274     325 ..     274     325 .. 0.82
   6 !   13.7   0.0   4.4e-06      0.04       1      46 [.     302     347 ..     302     350 .. 0.93
   7 !   29.7   0.0   4.3e-11   3.9e-07       2      48 ..     328     374 ..     327     376 .. 0.94
   8 !   21.3   0.6   1.9e-08   0.00017       1      39 [.     352     390 ..     352     462 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0014
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvk 35 
                 E +le vk+ ++++  l +   +Dk+++l+A++
  EFC36294.1 120 ETALEMVKRSPKCFSVLRS---KDKDVILEALN 149
                 6678888998888888754...4********98 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00018
     DUF4116   1 DrEivleavkkngsalky.....lseeLkn..DkeivlkAvkqngtalsyas 45 
                 D++++lea+ + + + +y     +   Lk+  D+e +++ + ++g++l+++ 
  EFC36294.1 140 DKDVILEALNT-PRIVRYtdldvIHRYLKSiqDREYAIQLITKYGKILDFLT 190
                 67777777777.45555533221333355566***************99986 PP

  == domain 3  score: 22.3 bits;  conditional E-value: 8.7e-09
     DUF4116   1 DrEivleavkkngsalkyls...eeLknDkeivlkAvkqngtalsyase 46 
                 D+E+ l a+k+ g++++ l+   +eL  Dk  v+++++ n+++++++++
  EFC36294.1 195 DEEMQLLAFKH-GWYITQLPqkwKELMEDKSNVMEILQTNKNIIKHIPK 242
                 99********9.999****955577888********************8 PP

  == domain 4  score: 13.0 bits;  conditional E-value: 6.9e-06
     DUF4116  16 lkylseeLknDkeivlkAvkqngt 39 
                 ++ +++e+ nDke++ k +k+  +
  EFC36294.1 264 INLIPKEILNDKEFIFKLLKKGYY 287
                 6779****************8665 PP

  == domain 5  score: 16.4 bits;  conditional E-value: 6.3e-07
     DUF4116   1 DrEivleavkkngsalky....lseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E++ +++kk g++++     + +++++D+++++ A  + ++++  ++ +Lr
  EFC36294.1 274 DKEFIFKLLKK-GYYFHLirfgILKNFSHDWDFMKTATSIEPSIFTICPIDLR 325
                 9**********.66555522144589999***************999998876 PP

  == domain 6  score: 13.7 bits;  conditional E-value: 4.4e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 D ++++ a ++ +s+++ ++ +L++ ke++l ++     ++++++e
  EFC36294.1 302 DWDFMKTATSIEPSIFTICPIDLRSQKEFALSCLDTVRESFRFIPE 347
                 569********************************99999999998 PP

  == domain 7  score: 29.7 bits;  conditional E-value: 4.3e-11
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 +E++l ++++  +++++++e L+ D++i+l+Avk++ ++l++++ ++
  EFC36294.1 328 KEFALSCLDTVRESFRFIPEFLQDDRDILLQAVKSDLSVLPRLPQDI 374
                 79*******999********************************765 PP

  == domain 8  score: 21.3 bits;  conditional E-value: 1.9e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 Dr+i l+avk++ s+l  l+ ++ +D+e +l +++++ +
  EFC36294.1 352 DRDILLQAVKSDLSVLPRLPQDILQDREKILTIIRSCEN 390
                 9**********************************9875 PP

>> HTH_44  Helix-turn-helix DNA-binding domain of SPT6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   1.0   1.3e-05      0.11      48     108 ..     171     231 ..     157     235 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.3e-05
                 TS---HHHHHHH-G..GGSB-SSTTS-....B--HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      HTH_44  48 kdelEvPfifqhRk..dyllhaekeekkaeklLneddLwriveldikfrsllekrnaleklye 108
                   e+ +  i ++ k  d+l h e++e+   +lL  +  w i +l +k+++l+e ++++ ++++
  EFC36294.1 171 DREYAIQLITKYGKilDFLTHFEEDEE--MQLLAFKHGWYITQLPQKWKELMEDKSNVMEILQ 231
                 555555666666555599999999976..9***************************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (566 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       784  (0.043728); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.52
# Mc/sec: 3297.20
//
Query:       EFC36295.1  [L=176]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.035   14.1   1.1      0.063   13.3   0.4    1.8  1  Complex1_LYR  Complex 1 protein (LYR family)
      0.065   12.7   2.5       0.53    9.7   2.5    2.2  1  Cir_Bir_Yir   Plasmodium variant antigen protein Cir/Yir/Bir


Domain annotation for each model (and alignments):
>> Complex1_LYR  Complex 1 protein (LYR family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.4   7.1e-06     0.063       3      36 ..      55      88 ..      53      93 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 7.1e-06
  Complex1_LYR  3 vLsLYRalLRearkfpdyntreyfrrriRdeFrk 36
                   L +YR+l + a++++++++r++  ++ + eF k
    EFC36295.1 55 LLEWYRKLVKRASYIESESKRKQVLAQLKSEFSK 88
                  6899****************************76 PP

>> Cir_Bir_Yir  Plasmodium variant antigen protein Cir/Yir/Bir
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   2.5     6e-05      0.53      90     177 ..      26     131 ..      24     156 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 6e-05
  Cir_Bir_Yir  90 eeeitnlndFYnkyiennekYkkkindv..................teyknykdlIdkkkelmnidikdi.skfYdafklLCnmyteldekksnckky 168
                  +++++++n FY++    n++ +++i+++                  +e k  + l + k e+ + + +d   k  + fk LC +  ++  +k++++k 
   EFC36295.1  26 NNHHQKVNCFYSTSSAANHH-TTTITSNsellewyrklvkrasyieSESKRKQVLAQLKSEFSKSSLNDWrRKAEESFKFLCMITPKVPISKQQQTKA 122
                  56667788888887777654.45555444777777777766666644444444455556666666666642567778888888888888888888888 PP

  Cir_Bir_Yir 169 lekaneFve 177
                   + +++Fv+
   EFC36295.1 123 NDGVTQFVK 131
                  888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1081  (0.0602934); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1051.32
//
Query:       EFC36296.1  [L=1164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-25   88.6   1.5    1.5e-12   47.9   0.0    5.1  4  Ank_2     Ankyrin repeats (3 copies)
    8.2e-22   77.3   9.3    3.4e-07   30.7   0.0    7.6  8  Ank_4     Ankyrin repeats (many copies)
    2.4e-20   70.4   5.9     0.0012   19.1   0.0    8.2  7  Ank_3     Ankyrin repeat
      5e-18   64.9   0.9     0.0003   21.0   0.0    7.2  7  Ank_5     Ankyrin repeats (many copies)
    8.4e-18   64.0   2.2    0.00049   20.4   0.1    7.4  6  Ank       Ankyrin repeat
  ------ inclusion threshold ------
      0.046   13.5   1.0        1.2    9.0   1.7    2.5  2  YkuI_C    EAL-domain associated signalling protein domain
       0.11   12.4   0.0       0.24   11.3   0.0    1.5  1  TPR_10    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.9   0.0     6e-16   1.5e-12       1      76 [.     192     286 ..     192     294 .. 0.77
   2 ?    1.3   0.0      0.21   5.3e+02       1      37 [.     302     346 ..     302     352 .. 0.65
   3 !   27.6   0.1   1.3e-09   3.3e-06      24      79 ..     427     499 ..     401     502 .. 0.71
   4 ?    5.1   0.0     0.013        34      49      63 ..     543     557 ..     529     566 .. 0.74

  Alignments for each domain:
  == domain 1  score: 47.9 bits;  conditional E-value: 6e-16
       Ank_2   1 LhlAakngnlelvklLl..egadpn...k.ngktaLhyAakngnleiv.klLleh............adndgrtpLhyAarsghleivklLlekg 76 
                 Lh A+++++++lv +Ll   g ++    + n  ++LhyA+++g+++ +  +L  +             dn g+tp+h+A++++h+ei+++L+++ 
  EFC36296.1 192 LHRACQFNKFKLVFFLLkyGGQNAFyvlDsNMSNPLHYACSSGSIQSItVYLGTYskygkqldissmRDNFGNTPIHVAIQNSHFEICQYLIDHQ 286
                 8*****98899******9544444355435889**********9977625555434567786766655599*********************873 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.21
       Ank_2   1 LhlAakngnlelvklLl.egadpn......k...ngktaLhyAakng 37 
                 Lh+ a+n +l+ +k+Ll    ++n      +   ++ t+  +A+k  
  EFC36296.1 302 LHQVAENFDLKGLKFLLeT--NANrspslhSqdqFKCTPFLHAIKCY 346
                 7888888557889999942..33333435414578889988888765 PP

  == domain 3  score: 27.6 bits;  conditional E-value: 1.3e-09
       Ank_2  24 k...ngktaLhyAakngnlei...vklLleh............adndgrtpLhyAarsghleivklLlekgadi 79 
                 +   ++++ Lh+++ ng  ++   ++ L                d++ +tpLh+A+ +g++e++k L+ +g++i
  EFC36296.1 427 QvdsQKRNCLHLSCLNGGDHCvdfIRVLFLTisaselcqlleaKDYEENTPLHLACHYGNIEVAKTLM-HGFQI 499
                 1334789********9955662225666632334456667665559999*******99*********9.88776 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.013
       Ank_2  49 adndgrtpLhyAars 63 
                  +++g+tpLh+A++ 
  EFC36296.1 543 RNKKGETPLHAAVSA 557
                 457888888888864 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.1    0.0001      0.26      26      55 .]     175     208 ..     165     208 .. 0.80
   2 !   20.9   0.1   1.5e-07   0.00038       3      51 ..     190     239 ..     188     243 .. 0.91
   3 !   30.7   0.0   1.3e-10   3.4e-07       3      55 .]     225     283 ..     223     283 .. 0.86
   4 !    8.8   0.0   0.00094       2.4       3      44 ..     300     344 ..     298     352 .. 0.87
   5 ?    2.4   0.1     0.098   2.5e+02      26      51 ..     423     451 ..     414     455 .. 0.71
   6 !   13.6   0.0   3.1e-05     0.079      30      54 ..     469     493 ..     445     494 .. 0.75
   7 !    6.0   0.0     0.007        18      27      44 ..     540     556 ..     531     563 .. 0.81
   8 ?    1.3   0.1      0.22   5.8e+02      22      37 ..     621     635 ..     612     636 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.0001
       Ank_4  26 dinaq....dnrsGetalhiAakrgnveilklLl 55 
                 di+a     ++++G ++lh+A+++++++ + +Ll
  EFC36296.1 175 DICAIkdftSDSRGASLLHRACQFNKFKLVFFLL 208
                 4555444446899*******************98 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 1.5e-07
       Ank_4   3 taLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveil 51 
                 ++Lh+a+++++++lv +Ll + g++  ++++++  ++lh+A++ g+++ +
  EFC36296.1 190 SLLHRACQFNKFKLVFFLLKYgGQNAFYVLDSNMSNPLHYACSSGSIQSI 239
                 78*******************88**99998998889**********9866 PP

  == domain 3  score: 30.7 bits;  conditional E-value: 1.3e-10
       Ank_4   3 taLhyaaisgrlelvrlLl....ekg..adinaqdnrsGetalhiAakrgnveilklLl 55 
                  +Lhya++sg ++++   l     +g   di    ++ G+t++h A++++++ei ++L+
  EFC36296.1 225 NPLHYACSSGSIQSITVYLgtysKYGkqLDISSMRDNFGNTPIHVAIQNSHFEICQYLI 283
                 58*****************9987446125566667999********************8 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.00094
       Ank_4   3 taLhyaaisgrlelvrlLlekgad....inaqdnrsGetalhiAak 44 
                 ++Lh+ a+ ++l+ +++Lle++a+    ++ q +    t++ +A+k
  EFC36296.1 300 SLLHQVAENFDLKGLKFLLETNANrspsLHSQ-DQFKCTPFLHAIK 344
                 78*****************8777766669999.99999******97 PP

  == domain 5  score: 2.4 bits;  conditional E-value: 0.098
       Ank_4  26 dinaqdnrsGetalhiAakrg.n..veil 51 
                 ++  q +++ +++lh  +++g +  v+++
  EFC36296.1 423 SLASQVDSQKRNCLHLSCLNGgDhcVDFI 451
                 456667999**********9963355555 PP

  == domain 6  score: 13.6 bits;  conditional E-value: 3.1e-05
       Ank_4  30 qdnrsGetalhiAakrgnveilklL 54 
                  ++ + +t+lh A+  gn+e++k L
  EFC36296.1 469 AKDYEENTPLHLACHYGNIEVAKTL 493
                 369999***************9977 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.007
       Ank_4  27 inaqdnrsGetalhiAak 44 
                    + n+ Get+lh A++
  EFC36296.1 540 FSLR-NKKGETPLHAAVS 556
                 5567.99*********97 PP

  == domain 8  score: 1.3 bits;  conditional E-value: 0.22
       Ank_4  22 ekgadinaqdnrsGet 37 
                 ++++dina  n++Ge+
  EFC36296.1 621 DSRVDINAK-NNNGES 635
                 579*****9.****86 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.0   2.2e-05     0.056       2      26 ..     188     211 ..     187     215 .. 0.89
   2 !    7.4   0.0    0.0032       8.1       4      16 ..     225     237 ..     222     246 .. 0.81
   3 !   19.1   0.0   4.7e-07    0.0012       2      26 ..     263     287 ..     262     292 .. 0.88
   4 ?    4.2   0.0     0.035        91       4      27 ..     300     322 ..     298     325 .. 0.87
   5 ?    0.2   0.0       0.7   1.8e+03       3      20 ..     433     450 ..     431     456 .. 0.76
   6 !   16.0   0.0     5e-06     0.013       3      22 ..     475     494 ..     473     501 .. 0.87
   7 ?    3.1   0.0      0.08     2e+02       2      11 ..     547     556 ..     546     557 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.2e-05
       Ank_3   2 GetpLhlAarsgnleivkfLlenkg 26 
                 G ++Lh+A+ ++++++v fLl+ +g
  EFC36296.1 188 GASLLHRACQFNKFKLVFFLLK-YG 211
                 899******************9.65 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0032
       Ank_3   4 tpLhlAarsgnle 16 
                 +pLh+A++sg++ 
  EFC36296.1 225 NPLHYACSSGSIQ 237
                 7*********985 PP

  == domain 3  score: 19.1 bits;  conditional E-value: 4.7e-07
       Ank_3   2 GetpLhlAarsgnleivkfLlenkg 26 
                 G+tp+h+A+ + ++ei+++L+++  
  EFC36296.1 263 GNTPIHVAIQNSHFEICQYLIDHQP 287
                 9*********************654 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.035
       Ank_3   4 tpLhlAarsgnleivkfLlenkga 27 
                 ++Lh++a++ +l+ +kfLle  +a
  EFC36296.1 300 SLLHQVAENFDLKGLKFLLE-TNA 322
                 89*****************9.454 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.7
       Ank_3   3 etpLhlAarsgnleivkf 20 
                 ++ Lhl +++g    v+f
  EFC36296.1 433 RNCLHLSCLNGGDHCVDF 450
                 689*******98754444 PP

  == domain 6  score: 16.0 bits;  conditional E-value: 5e-06
       Ank_3   3 etpLhlAarsgnleivkfLl 22 
                 +tpLhlA+++gn+e++k L 
  EFC36296.1 475 NTPLHLACHYGNIEVAKTLM 494
                 9*************999886 PP

  == domain 7  score: 3.1 bits;  conditional E-value: 0.08
       Ank_3   2 GetpLhlAar 11 
                 GetpLh A++
  EFC36296.1 547 GETPLHAAVS 556
                 9******997 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.0    0.0052        13      11      56 .]     183     230 ..     179     230 .. 0.77
   2 !    5.9   0.0    0.0063        16       1      35 [.     207     242 ..     207     253 .. 0.71
   3 !   21.0   0.0   1.2e-07    0.0003      12      43 ..     259     290 ..     254     303 .. 0.82
   4 ?   -1.3   0.0       1.2   2.9e+03      16      27 ..     432     443 ..     424     452 .. 0.75
   5 !   19.1   0.1   4.7e-07    0.0012      11      36 ..     469     494 ..     465     505 .. 0.85
   6 ?    3.1   0.0     0.048   1.2e+02      12      25 ..     543     556 ..     541     562 .. 0.84
   7 ?    2.3   0.0     0.085   2.2e+02      34      54 ..     616     638 ..     610     638 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0052
       Ank_5  11 rldgggntpLhvAakygaadvvrlLlarga..dlnltdsrGltaldlA 56 
                 ++d +g + Lh A+  + + +v +Ll++g   +  + ds+ +++l++A
  EFC36296.1 183 TSDSRGASLLHRACQFNKFKLVFFLLKYGGqnAFYVLDSNMSNPLHYA 230
                 5788999*******************6665114466666667777776 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0063
       Ank_5   1 Llehg.padvnrldgggntpLhvAakygaadvvrlL 35 
                 Ll++g +++   ld +  +pLh+A++ g+ + + ++
  EFC36296.1 207 LLKYGgQNAFYVLDSNMSNPLHYACSSGSIQSITVY 242
                 566666666666777777********8887766555 PP

  == domain 3  score: 21.0 bits;  conditional E-value: 1.2e-07
       Ank_5  12 ldgggntpLhvAakygaadvvrlLlargadln 43 
                 +d++gntp+hvA+ + +++++++L++++  l 
  EFC36296.1 259 RDNFGNTPIHVAIQNSHFEICQYLIDHQPQLI 290
                 699**********************6665544 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 1.2
       Ank_5  16 gntpLhvAakyg 27 
                 + ++Lh+++ +g
  EFC36296.1 432 KRNCLHLSCLNG 443
                 349******987 PP

  == domain 5  score: 19.1 bits;  conditional E-value: 4.7e-07
       Ank_5  11 rldgggntpLhvAakygaadvvrlLl 36 
                 ++d + ntpLh+A++yg+ +v++ L+
  EFC36296.1 469 AKDYEENTPLHLACHYGNIEVAKTLM 494
                 6788889****************998 PP

  == domain 6  score: 3.1 bits;  conditional E-value: 0.048
       Ank_5  12 ldgggntpLhvAak 25 
                 ++++g+tpLh A++
  EFC36296.1 543 RNKKGETPLHAAVS 556
                 6899********98 PP

  == domain 7  score: 2.3 bits;  conditional E-value: 0.085
       Ank_5  34 lLl..argadlnltdsrGltald 54 
                 ++l  + ++d+n+++++G+++++
  EFC36296.1 616 NYLwgDSRVDINAKNNNGESVYE 638
                 44447789**********99986 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0      0.02        52       2      24 ..     188     211 ..     187     218 .. 0.81
   2 ?    5.5   0.0      0.01        26       5      18 ..     226     239 ..     224     248 .. 0.81
   3 !   16.0   0.0   4.8e-06     0.012       2      23 ..     263     285 ..     262     293 .. 0.87
   4 ?    0.8   0.1      0.32   8.1e+02       5      19 ..     435     452 ..     433     469 .. 0.68
   5 !   20.4   0.1   1.9e-07   0.00049       2      30 ..     474     503 ..     473     505 .. 0.83
   6 !    7.8   0.0    0.0019       4.7       2      32 .]     547     631 ..     546     631 .. 0.52

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.02
                 SBBHHHHHHHHTTHHHHHHHH.TT CS
         Ank   2 GnTPLHlAatngkkriiklLL.hG 24 
                 G + LH+A++++k   + +LL +G
  EFC36296.1 188 GASLLHRACQFNKFKLVFFLLkYG 211
                 6688*****999988999999765 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.01
                 HHHHHHHHTTHHHH CS
         Ank   5 PLHlAatngkkrii 18 
                 PLH+A++ g+ + i
  EFC36296.1 226 PLHYACSSGSIQSI 239
                 9*****99976655 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 4.8e-06
                 SBBHHHHHHHHTTHHHHHHHH.T CS
         Ank   2 GnTPLHlAatngkkriiklLL.h 23 
                 GnTP H+A++n + +i+++L+ h
  EFC36296.1 263 GNTPIHVAIQNSHFEICQYLIdH 285
                 9********************66 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.32
                 HHHHHHHHTT...HHHHH CS
         Ank   5 PLHlAatngk...kriik 19 
                 +LHl + ng+   ++ i+
  EFC36296.1 435 CLHLSCLNGGdhcVDFIR 452
                 6***99888844544444 PP

  == domain 5  score: 20.4 bits;  conditional E-value: 1.9e-07
                 SBBHHHHHHHHTTHHHHHHHHTT.TSTTCB CS
         Ank   2 GnTPLHlAatngkkriiklLLhG.Anlnal 30 
                  nTPLHlA+++g+ +++k L hG   ln +
  EFC36296.1 474 ENTPLHLACHYGNIEVAKTLMHGfQILNEH 503
                 59******************9995335665 PP

  == domain 6  score: 7.8 bits;  conditional E-value: 0.0019
                 SBBHHHHH......................................HHHTT.................HHHHHHHH.T.TTSTTCBTT CS
         Ank   2 GnTPLHlA......................................atngk.................kriiklLL.h.GAnlnaldn 32 
                 G TPLH A                                          k                  +ii +L  + + ++na++n
  EFC36296.1 547 GETPLHAAvsalgdlnrkrnsimvngallseptsptsptnsipassG---KrkksfveiqlkekkmniISIINYLWgDsRVDINAKNN 631
                 99*****8555555555555555555555555555555554443320...12334444444555544444555566632478888876 PP

>> YkuI_C  EAL-domain associated signalling protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   1.7   0.00046       1.2       2      64 ..     780     844 ..     779     851 .. 0.79
   2 ?    0.5   0.0      0.18   4.7e+02      35      82 ..    1016    1064 ..    1007    1069 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00046
      YkuI_C   2 verdllkdklkkefhqfiayekkklealyelseklkkrlkellkkl.kkaedyd.elllklakel 64 
                 ++r++  ++  k++++f++ e kk ++ y++se++ kr+k+ l+ + kk+++   el  ++++e+
  EFC36296.1 780 IDRKVAFERKWKKVNEFLKDELKKKHISYSISEMFMKRVKRDLNLVfKKDQKASfELGRRISQEI 844
                 6777788888899***************************9888651444444456666777766 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.18
      YkuI_C   35 klkkrlkellkklkkaedydelllklakeld.evafrvyicdedGiqqs 82  
                  +l +++ +++ k +  ++++ ll k+  + +  + fr+  c+ dG+  s
  EFC36296.1 1016 QLIAQFGKVVPKKEILKNIETLLPKINDDPNlPLIFRITACNFDGYVGS 1064
                  66678889999999999999999999998763689**********8766 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   9.4e-05      0.24      23      41 ..     695     713 ..     694     714 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 9.4e-05
      TPR_10  23 alleealairrrllGpdHP 41 
                 +l+ +++ ++r+l+G+dHP
  EFC36296.1 695 KLQSKCVKLYRKLFGDDHP 713
                 57779*************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       672  (0.0374812); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.87u 0.33s 00:00:01.20 Elapsed: 00:00:00.50
# Mc/sec: 6956.72
//
Query:       EFC36297.1  [L=698]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-13   50.1   0.1    1.1e-09   38.5   0.2    2.9  3  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.5   0.2   5.9e-14   1.1e-09       4      59 ..      84     148 ..      82     155 .. 0.91
   2 !    7.9   0.0   0.00021       3.8      57      91 ..     181     219 ..     176     230 .. 0.83
   3 ?   -2.6   0.0      0.37   6.6e+03      80      95 ..     276     291 ..     263     298 .. 0.70

  Alignments for each domain:
  == domain 1  score: 38.5 bits;  conditional E-value: 5.9e-14
                 EEEEEEEESSSSSSTTSSCEEEEEEEE.........ECEEEEEE-SCSSSSSSEEEEEEEEEESC CS
          C2   4 evtvieAknLpnkdkkgssdpyvkvsl.........dgkqkakTrviknslnPvWnekftfevae 59 
                  v+vi A++L +kdk+g sdpy  v++         ++  +akT ++k++lnP Wne+f+++++e
  EFC36297.1  84 MVRVIGATDLVPKDKNGFSDPYSIVTFtntdpngiqENWLTAKTATKKKTLNPSWNETFQINLTE 148
                 699*****************************998878888999999*************99887 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00021
                 ESC....HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHH CS
          C2  57 vae....leeakLeveVfdndrlskddfiGkveiplstl 91 
                 +++    l++++  ++++d+d++s+d+  G v+++l+++
  EFC36297.1 181 IPNdlnpLSTSTFNFKIMDYDMFSSDENEGDVSLKLTSI 219
                 555555589999**********************99885 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.37
                 EEEEEEEEGHHHHTTH CS
          C2  80 fiGkveiplstllsge 95 
                 +iG+v+ pls  + g 
  EFC36297.1 276 LIGTVNYPLSPWEMGP 291
                 8********9955554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (698 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 3984.01
//
Query:       EFC36298.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.6e-18   65.0   0.0    6.6e-18   65.0   0.0    2.0  2  PRiA4_ORF3      Plasmid pRiA4b ORF-3-like protein
  ------ inclusion threshold ------
       0.12   12.4  15.5       0.24   11.5  15.5    1.5  1  YL1             YL1 nuclear protein
       0.34    9.1  16.2       0.48    8.6  16.2    1.2  1  Nop14           Nop14-like family
       0.37   11.0   2.0       0.43   10.8   0.1    2.0  3  CCG             Cysteine-rich domain
        1.5    7.3  29.9        2.6    6.5  29.9    1.3  1  TFIIF_alpha     Transcription initiation factor IIF, alpha su
          2    6.8  16.6        2.8    6.3  16.6    1.2  1  SGT1            SGT1 protein
        4.7    7.1  11.9        9.2    6.2  11.9    1.6  1  Pox_RNA_Pol_19  Poxvirus DNA-directed RNA polymerase 19 kDa s


Domain annotation for each model (and alignments):
>> PRiA4_ORF3  Plasmid pRiA4b ORF-3-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   1.6       0.5   1.3e+03      48      89 ..      50      93 ..      34      96 .. 0.58
   2 !   65.0   0.0   2.6e-21   6.6e-18      24     114 ..     132     217 ..     109     244 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.5
  PRiA4_ORF3 48 eFeieekryge..eeeedeeeeeevldeskvklddvlkekgkkl 89
                eFe + + y +   eee  +ee++  +e++  +++v+++k+kk 
  EFC36298.1 50 EFEKRMEMYMKemLEEEGIDEESDESEEETKIVKKVVEPKKKKQ 93
                56665566666442233333444444444455677777777765 PP

  == domain 2  score: 65.0 bits;  conditional E-value: 2.6e-21
  PRiA4_ORF3  24 editlarLhevlqaafgwedyHlheFeieekrygeeeeedeeeeeevldeskvklddvlkekgkkltyeYDfgdsWeheielekvledkee 114
                 ++++l+ Lh++l+ af+w+d Hlh F++ +      e +d++  +e ++esk++ld+vl+++ +++ y+YDf  +W+ +i lek+l+++  
  EFC36298.1 132 QNANLRHLHNLLMYAFDWDDGHLHMFHTCKG-----EFTDRSMCQEGKEESKCRLDSVLNRSVDSIDYVYDFSSEWNISISLEKILTEQAM 217
                 6899************************333.....35668899999***************************************99654 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  15.5   9.5e-05      0.24      13      97 ..       3     100 ..       1     135 [. 0.52

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 9.5e-05
                 xxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxx..............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1  13 kLleqeee...edelellFaEeedDeefeseeeeeeee..............nsDsdfdsdeedeesdeeedeeegekelerqerkkrkkekkkrkaqk 94 
                 kLl++++    +d+ +  +  ++dD +++++e+ eee                 ++ + +  e+e  dee+de+e+e ++ ++  + +   kkk+k ++
  EFC36298.1   3 KLLANKQGsddDDDDD-DYYSDDDDGDYTDDEDGEEELynsgdrtekeefekRMEMYMKEMLEEEGIDEESDESEEETKIVKKVVEPK---KKKQKMES 97 
                 6665554344222222.23446666666666555554466666666665544444444444444444555555555554444444444...22222222 PP

                 xxx RF
         YL1  95 kks 97 
                  +s
  EFC36298.1  98 GQS 100
                 222 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  16.2   0.00019      0.48     352     437 ..      11     104 ..       2     132 .. 0.36

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00019
       Nop14 352 eddfeedddlveseseeeeeeeeedeeeeedeeeeeeeeededdlsdlese.......eeeeedeleeel.....leeekkaaeekkekkkkkkksee 437
                 +dd+++ddd  +++++ +  +++ed eee  ++ +  e+e+ ++ +++ ++        +ee+de eee+     ++e kk++++ +   + +++s++
  EFC36298.1  11 SDDDDDDDDYYSDDDDGD-YTDDEDGEEELYNSGDRTEKEEFEKRMEMYMKemleeegIDEESDESEEETkivkkVVEPKKKKQKME---SGQSASSS 104
                 222222222222222222.23333333332222222111222222222222234445633333333333333432222222222221...22233322 PP

>> CCG  Cysteine-rich domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       2.2   5.6e+03      55      67 ..      52      64 ..      42      83 .. 0.55
   2 ?   -3.6   0.0       5.5   1.4e+04      15      26 ..      76      87 ..      69      96 .. 0.58
   3 ?   10.8   0.1   0.00017      0.43      17      65 ..     213     267 ..     208     269 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.2
         CCG 55 ealakrnvetaee 67
                e+ +++ ++++ e
  EFC36298.1 52 EKRMEMYMKEMLE 64
                3333333333332 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 5.5
         CCG 15 pevrkalkklle 26
                +e +k++kk++e
  EFC36298.1 76 EEETKIVKKVVE 87
                444445555543 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 0.00017
         CCG  17 vrkalkkllealgveleel..ekesCCGagggrsgkee....laealakrnveta 65 
                 +++a+k+  e+l++el+    +  +CCG  gg  ++e      +++++k+n + +
  EFC36298.1 213 TEQAMKAQAEKLNIELPNDltKVVYCCGGLGGSIDEESgkkkGTFDINKENKRKF 267
                 678999999******998767889*******987776654335668888887665 PP

>> TFIIF_alpha  Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  29.9     0.001       2.6     259     358 ..       8     106 ..       3     110 .. 0.40

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.001
                  XXXXXXXXXXXX.XXXX..XX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  TFIIF_alpha 259 kkkrgsdddadeydsdd..Gd....degrEldyisDdsasendpeeredkkseEeeekkeieqdedeeekeeekkeeegklskkkkkakklkkkkkek 350
                  k+  ++ddd+d+y sdd  Gd    + g E+ y s d +++++ e+r ++  +E       e  e+  ++e++++eee k  kk  ++kk+k+k +  
   EFC36298.1   8 KQGSDDDDDDDDYYSDDddGDytddEDGEEELYNSGDRTEKEEFEKRMEMYMKEML-----E--EEGIDEESDESEEETKIVKKVVEPKKKKQKMESG 98 
                  23334444444443333003211112333444444444433333333332222222.....2..2223344445556666777777777666655555 PP

                  ..XXXXXX CS
  TFIIF_alpha 351 dkkdSdde 358
                  +  +S+++
   EFC36298.1  99 QSASSSSG 106
                  44444444 PP

>> SGT1  SGT1 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  16.6    0.0011       2.8     479     567 ..       3      96 ..       1     110 [. 0.63

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0011
        SGT1 479 kllgskieeeldsddld.edssedsdeedeedeeee.ea..eeeskeeekeslksYmdqm.deELaqttvgksFekkkkkkekakkkeekeets 567
                 kll +k+  + d+dd d  ++++d d+ d+ed eee  +  ++++kee ++ ++ Ym++m +eE    + ++s e++k  k+  + k++k++ +
  EFC36298.1   3 KLLANKQGSDDDDDDDDyYSDDDDGDYTDDEDGEEElYNsgDRTEKEEFEKRMEMYMKEMlEEEGIDEESDESEEETKIVKKVVEPKKKKQKME 96 
                 677777777777766666778888888888887776533467888889999******9994445555556666666655554444444333332 PP

>> Pox_RNA_Pol_19  Poxvirus DNA-directed RNA polymerase 19 kDa subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2  11.9    0.0036       9.2       2      74 ..      12      91 ..      11     116 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0036
  Pox_RNA_Pol_19  2 edsedivdyasedeeseyeeeeedeeees..slessdvsslkese.ykvekvss.nvee...eessskqvsekisaikkr 74
                    +d +d +dy+s+d++ +y+++e+ eee    +  +++ +  k+ e y  e ++   ++e   e++++ ++ +k+ + kk+
      EFC36298.1 12 DDDDDDDDYYSDDDDGDYTDDEDGEEELYnsGDRTEKEEFEKRMEmYMKEMLEEeGIDEesdESEEETKIVKKVVEPKKK 91
                    5778889************9998877654333333333333333324435555444444333556666788888877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1630  (0.0909142); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 1642.07
//
Query:       EFC36299.1  [L=582]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.8e-25   88.7   5.2    7.3e-08   32.9   0.1    5.6  5  RCC1       Regulator of chromosome condensation (RCC1) repeat
    5.6e-21   73.8  13.7    6.2e-06   25.9   0.2    5.8  6  RCC1_2     Regulator of chromosome condensation (RCC1) repeat
    6.1e-06   25.9  10.5     0.0083   15.9   1.2    2.8  2  zf-CCCH_4  CCCH-type zinc finger
    0.00064   19.6  13.3      0.016   15.1   1.4    3.3  4  zf-CCCH    Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  ------ inclusion threshold ------
      0.016   15.6   8.8        1.1    9.9   1.3    2.9  2  zf-CCCH_2  RNA-binding, Nab2-type zinc finger
      0.022   15.3   0.9       0.51   10.9   0.2    2.5  2  oligo_HPY  Oligopeptide/dipeptide transporter, C-terminal reg
        0.2   11.7  20.8       0.08   13.0   2.8    3.5  4  zf_CCCH_4  Zinc finger domain
        3.6    8.7  13.0        1.8    9.7   1.3    3.3  3  DUF5123    Domain of unknown function (DUF5123)


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.9   0.1   3.3e-11   7.3e-08       1      50 []     275     328 ..     275     328 .. 0.92
   2 !   28.7   0.0   6.7e-10   1.5e-06       1      50 []     331     384 ..     331     384 .. 0.75
   3 !    8.0   0.2     0.002       4.4       2      50 .]     388     440 ..     388     440 .. 0.70
   4 !   16.0   0.0   6.5e-06     0.015       2      42 ..     444     484 ..     444     491 .. 0.81
   5 ?   -2.8   0.0       4.7   1.1e+04       3      12 ..     498     507 ..     496     507 .. 0.86

  Alignments for each domain:
  == domain 1  score: 32.9 bits;  conditional E-value: 3.3e-11
                 TTEEEEEE--GGGTTSSSS-..--EEEEEE-..GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt..esvlvPtkv..eglsgnrvvkvacGddhtval 50 
                 dG+++s G+n++GqLG g++   ++ vP  +  e ++++ vv+va G+dh+++l
  EFC36299.1 275 DGSLLSQGCNSFGQLGKGKKdlSDSFVPFHIpaEYFQNQQVVDVALGQDHVLVL 328
                 8*******************888889**99977788888************986 PP

  == domain 2  score: 28.7 bits;  conditional E-value: 6.7e-10
                 TTEEEEEE--GGGTTSSSS-.--E..EEEEE-GGGTTS...-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt.esv..lvPtkveglsgn...rvvkvacGddhtval 50 
                 +G+V+s G n++Gq+G     ++      t+v+++ +     +vkvacGd h+++l
  EFC36299.1 331 NGQVFSVGINEKGQCGVDALlDRIldF--TLVKFPYESeqeFIVKVACGDEHSLCL 384
                 6****************9996333331..4444443334459************97 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.002
                 TEEEEEE--GGGTTSSSS-....--EEEEEE-GGGTTS...-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt....esvlvPtkveglsgn...rvvkvacGddhtval 50 
                 G+Vy++G n y+q    t+    e+    +k++   +    ++v+++cG +++++l
  EFC36299.1 388 GNVYGCGYNLYNQIDPDTNatlfEKF---KKIAIQLAYqqdKIVDISCGPQYSAFL 440
                 78888888888888887776665444...455333333448*********999986 PP

  == domain 4  score: 16.0 bits;  conditional E-value: 6.5e-06
                 TEEEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS-EEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt.esvlvPtkveglsgnrvvkvac 42 
                 G+Vy +G+n++ q+ l+++  +v+ Pt ++  + + ++kv c
  EFC36299.1 444 GQVYMCGQNTFSQCCLPSKqTKVTSPTHINIRN-EFIKKVIC 484
                 9***************999555588****8744.46666888 PP

  == domain 5  score: -2.8 bits;  conditional E-value: 4.7
                 EEEEEE--GG CS
        RCC1   3 rVysWGrndy 12 
                 ++y+ G+ndy
  EFC36299.1 498 EIYAAGSNDY 507
                 79******97 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       1.6   3.6e+03      12      22 ..     211     221 ..     200     222 .. 0.67
   2 !    9.3   0.2   0.00043      0.97      11      30 .]     269     288 ..     266     288 .. 0.91
   3 !   25.9   0.2   2.8e-09   6.2e-06       1      30 []     315     344 ..     315     344 .. 0.99
   4 !   23.6   1.2   1.4e-08   3.2e-05       1      30 []     371     400 ..     371     400 .. 0.95
   5 !   12.4   0.0   4.6e-05       0.1       1      30 []     427     456 ..     427     456 .. 0.96
   6 !    7.1   0.0    0.0022       4.9       7      28 ..     486     507 ..     479     508 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.6
      RCC1_2  12 caLtedGeVlc 22 
                 +  ++dG+V+ 
  EFC36299.1 211 FLALSDGTVWN 221
                 55578999985 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00043
      RCC1_2  11 scaLtedGeVlcWGsNsdGQ 30 
                 s  Lt dG +l+ G+Ns+GQ
  EFC36299.1 269 SYYLTKDGSLLSQGCNSFGQ 288
                 6679***************9 PP

  == domain 3  score: 25.9 bits;  conditional E-value: 2.8e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V++v+ G +H ++Lt++G V++ G N+ GQ
  EFC36299.1 315 VVDVALGQDHVLVLTSNGQVFSVGINEKGQ 344
                 89***************************9 PP

  == domain 4  score: 23.6 bits;  conditional E-value: 1.4e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +++v++Gd Hs+ L++ G+V+++G N + Q
  EFC36299.1 371 IVKVACGDEHSLCLSNLGNVYGCGYNLYNQ 400
                 799***********************8887 PP

  == domain 5  score: 12.4 bits;  conditional E-value: 4.6e-05
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++s+G   s +L+  G V+ +G+N++ Q
  EFC36299.1 427 IVDISCGPQYSAFLSKFGQVYMCGQNTFSQ 456
                 79*************************977 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.0022
      RCC1_2   7 GdyHscaLtedGeVlcWGsNsd 28 
                  ++ ++++t+++e+++ GsN++
  EFC36299.1 486 KGSTTFFITRENEIYAAGSNDY 507
                 567899**************75 PP

>> zf-CCCH_4  CCCH-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   2.4   1.6e-05     0.035       9      21 ..      88     101 ..      85     102 .. 0.90
   2 !   15.9   1.2   3.7e-06    0.0083       2      21 ..     104     136 ..     103     136 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.6e-05
   zf-CCCH_4   9 G.sCrfGdnCrFsH 21 
                 + +C +Gd+C FsH
  EFC36299.1  88 NkGCSYGDRCLFSH 101
                 558*********** PP

  == domain 2  score: 15.9 bits;  conditional E-value: 3.7e-06
   zf-CCCH_4   2 lCpyfa.............kGsCrfGdnCrFsH 21 
                 +C+++              +  C fG nC+++H
  EFC36299.1 104 VCKHYKqvaissennlnqlTPACQFGKNCKYLH 136
                 799998899999999999999************ PP

>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.2       3.1   6.9e+03       2       9 ..      51      58 ..      50      60 .. 0.69
   2 !   15.1   1.4   7.1e-06     0.016      14      26 ..      90     102 ..      83     103 .. 0.87
   3 ?   -2.1   0.0       1.8   4.1e+03       4      11 ..     103     110 ..     102     110 .. 0.80
   4 !   12.2   0.2   5.9e-05      0.13      14      25 ..     125     136 ..     123     138 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.1
                HCHCBCHH CS
     zf-CCCH  2 ktelCrff 9 
                   +C f+
  EFC36299.1 51 EKNPCSFH 58
                56788887 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 7.1e-06
                 --TTGGG-SSBSC CS
     zf-CCCH  14 yCkyGdrCkFaHg 26 
                  C+yGdrC F+H+
  EFC36299.1  90 GCSYGDRCLFSHS 102
                 7***********7 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.8
                 HCBCHHHH CS
     zf-CCCH   4 elCrffmr 11 
                 + C+++++
  EFC36299.1 103 AVCKHYKQ 110
                 57**9976 PP

  == domain 4  score: 12.2 bits;  conditional E-value: 5.9e-05
                 --TTGGG-SSBS CS
     zf-CCCH  14 yCkyGdrCkFaH 25 
                 +C++G +Ck+ H
  EFC36299.1 125 ACQFGKNCKYLH 136
                 5*********** PP

>> zf-CCCH_2  RNA-binding, Nab2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   1.3   0.00048       1.1       7      17 ..      90     101 ..      85     101 .. 0.85
   2 ?    8.9   1.1   0.00098       2.2       6      17 ..     124     136 ..     124     136 .. 0.94

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00048
   zf-CCCH_2   7 nC.tnpkCpFaH 17 
                  C ++++C F+H
  EFC36299.1  90 GCsYGDRCLFSH 101
                 4*********** PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00098
   zf-CCCH_2   6 pnC.tnpkCpFaH 17 
                 p+C ++++C++ H
  EFC36299.1 124 PACqFGKNCKYLH 136
                 89*********99 PP

>> oligo_HPY  Oligopeptide/dipeptide transporter, C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.2   0.00023      0.51      43      64 ..      81     103 ..      59     105 .. 0.75
   2 ?    2.2   0.0      0.12   2.6e+02      42      60 ..     116     134 ..     106     137 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00023
   oligo_HPY  43 p.slerldeGCpFapRCpfalee 64 
                   + +++++GC + +RC f  ++
  EFC36299.1  81 SnQNQNHNKGCSYGDRCLFSHSA 103
                 336678888********998776 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.12
   oligo_HPY  42 apslerldeGCpFapRCpf 60 
                 + +l++l  +C+F ++C++
  EFC36299.1 116 ENNLNQLTPACQFGKNCKY 134
                 3466677779*******97 PP

>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   2.8   3.6e-05      0.08       9      19 .]      91     101 ..      87     101 .. 0.91
   2 ?   -1.8   0.5       1.6   3.6e+03       1       6 [.     105     110 ..     105     110 .. 0.90
   3 ?   10.9   1.5   0.00017      0.37       9      19 .]     126     136 ..     125     136 .. 0.97
   4 ?   -2.3   0.0       2.3   5.2e+03       9      13 ..     484     488 ..     483     489 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.6e-05
   zf_CCCH_4   9 CkkGdkCrFaH 19 
                 C++Gd+C F+H
  EFC36299.1  91 CSYGDRCLFSH 101
                 *********** PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.6
   zf_CCCH_4   1 Ckfflq 6  
                 Ck+++q
  EFC36299.1 105 CKHYKQ 110
                 ****87 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 0.00017
   zf_CCCH_4   9 CkkGdkCrFaH 19 
                 C++G +C+++H
  EFC36299.1 126 CQFGKNCKYLH 136
                 *********** PP

  == domain 4  score: -2.3 bits;  conditional E-value: 2.3
   zf_CCCH_4   9 CkkGd 13 
                 C+kG+
  EFC36299.1 484 CTKGS 488
                 ****7 PP

>> DUF5123  Domain of unknown function (DUF5123)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   2.2     0.033        74      34     109 ..      96     176 ..       7     180 .. 0.79
   2 ?   -2.6   0.0       5.1   1.1e+04       7      34 ..     218     245 ..     214     272 .. 0.66
   3 ?    9.7   1.3   0.00079       1.8       5      64 ..     451     507 ..     448     535 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.033
     DUF5123  34 nnif.kktvneatagtlratknltvkfsnnnyltsdfesssekeaatn....ataltsdplFkdpangDFtitsesllaka 109
                 +++f  + v++ +++ +++++n+  + +  + + +++++   ++++t+       l  + +F d +  D  i +e++l+k 
  EFC36299.1  96 RCLFsHSAVCKHYKQVAISSENNLNQLTPACQFGKNCKYLHIDFKDTKakreLKVLANSSQFSDMNRTDWFIRKENPLKKH 176
                 6788866666666666666666666666666666666666666666555554456777779*************9999875 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 5.1
     DUF5123   7 Tfyntnansgllfvdkkttssstltvtn 34 
                 T++n++++  +  ++ +++ s+t t+tn
  EFC36299.1 218 TVWNCSKEALMSGIHGQKEISNTNTLTN 245
                 6666555555666663333444444444 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00079
     DUF5123   5 ncTfyntnansgllfvdkkttssstltvtnnifkktvneatagtlratknlt.vkfsnnny 64 
                 ++Tf++++ +s+++ v     s+++++++n  +kk+++++++ t + t++++    ++n y
  EFC36299.1 451 QNTFSQCCLPSKQTKVT----SPTHINIRNEFIKKVICTKGSTTFFITRENEiYAAGSNDY 507
                 79****99999996666....899************9999988877666554045555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (582 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       630  (0.0351386); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 3672.74
//
Query:       EFC36300.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0017   18.3   0.8     0.0017   18.3   0.8    2.6  2  TPR_2     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.015   15.1   2.2       0.03   14.1   0.6    2.3  2  TPR_1     Tetratricopeptide repeat
      0.033   14.4   1.9       0.25   11.6   0.3    2.4  2  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
       0.12   12.7   3.0       0.15   12.3   0.3    2.7  3  TPR_8     Tetratricopeptide repeat
       0.18   12.5   1.3        2.2    9.1   0.2    3.2  4  TPR_6     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       2.1   7.5e+03       6      17 ..      83      94 ..      80      96 .. 0.71
   2 !   18.3   0.8   4.8e-07    0.0017       2      31 ..     202     231 ..     201     234 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.1
       TPR_2  6 nlGlayyklgdy 17
                n ++a  klg++
  EFC36300.1 83 NYAYANKKLGEF 94
                567777788877 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 4.8e-07
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleld 31 
                  a+y+lG+ y+k ++ye+A ++f+ A + +
  EFC36300.1 202 FAHYALGKFYLKTKQYERAMDHFNVAASRN 231
                 69*********************9887665 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.6   8.4e-06      0.03       3      25 ..     203     225 ..     202     225 .. 0.96
   2 ?   -1.5   0.0      0.74   2.7e+03      22      28 ..     230     236 ..     226     237 .. 0.60

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 8.4e-06
                 HHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyye 25 
                 a+y lG  y+k ++y+ A ++++
  EFC36300.1 203 AHYALGKFYLKTKQYERAMDHFN 225
                 89*******************96 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.74
                 HHHHHHH CS
       TPR_1  22 eyyekAL 28 
                   y+kA+
  EFC36300.1 230 RNYKKAI 236
                 4456655 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.1      0.08   2.9e+02      17      38 ..     103     124 ..      81     149 .. 0.85
   2 ?   11.6   0.3   6.9e-05      0.25      25      49 ..     203     227 ..     187     243 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.08
                 .HHH--HHHHHHHHHHHHHTT- CS
      ANAPC3  17 aaetespedayllAlclylngq 38 
                 + ++++  ++yl++l l+ ++q
  EFC36300.1 103 TFQNNNQVALYLHSLLLFDSKQ 124
                 4667888889999****99998 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 6.9e-05
                 HHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  25 dayllAlclylngqykrAyellrka 49 
                 + y+l++ +++++qy+rA++ ++ a
  EFC36300.1 203 AHYALGKFYLKTKQYERAMDHFNVA 227
                 56889**************999887 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       1.7   6.2e+03       6      18 ..      83      95 ..      82      96 .. 0.81
   2 ?   12.3   0.3   4.3e-05      0.15       3      25 ..     203     225 ..     203     234 .. 0.86
   3 ?   -2.7   0.0       2.8     1e+04      21      28 ..     234     241 ..     229     244 .. 0.63

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.7
                HHHHHHHHTT-HH CS
       TPR_8  6 nlgsiylklgdye 18
                n +++ +klg++ 
  EFC36300.1 83 NYAYANKKLGEFT 95
                7899999999875 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 4.3e-05
                 HHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyye 25 
                 a+y lg+ ylk+++ye A+  ++
  EFC36300.1 203 AHYALGKFYLKTKQYERAMDHFN 225
                 689****************9987 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 2.8
                 HHHHHHHH CS
       TPR_8  21 keyyekal 28 
                 k+ +e+al
  EFC36300.1 234 KAILEQAL 241
                 45566665 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1         5   1.8e+04      15      27 ..      83      95 ..      79      97 .. 0.52
   2 ?   -2.8   0.0       3.7   1.3e+04      23      31 ..     164     172 ..     161     174 .. 0.79
   3 ?    9.1   0.2   0.00062       2.2       2      27 ..     203     228 ..     202     232 .. 0.88
   4 ?   -0.2   0.0      0.55     2e+03       2      26 ..     235     266 ..     234     267 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 5
                HHHHHHHHHHHHH CS
       TPR_6 15 dtdkAlealerli 27
                +++ A + l ++ 
  EFC36300.1 83 NYAYANKKLGEFT 95
                5555555555554 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.7
                 HHHHHHH-T CS
       TPR_6  23 lerlikeYP 31 
                 +e l+ +Y 
  EFC36300.1 164 YETLLAKYD 172
                 999999996 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00062
                 HHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerli 27 
                 A y l++ y+k++++++A++ ++   
  EFC36300.1 203 AHYALGKFYLKTKQYERAMDHFNVAA 228
                 8899*******99*******998765 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.55
                 HHHHHHHHHHHH.......HHHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl.......gdtdkAlealerl 26 
                 A + +al++r++       +++ k+le+++++
  EFC36300.1 235 AILEQALLLRSGspdgvisKNPFKSLELFKQV 266
                 67888999998888888888888999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 2116.79
//
Query:       EFC36301.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.7e-33  114.2   9.2    7.6e-33  113.8   9.2    1.2  1  Ribosomal_S3Ae   Ribosomal S3Ae family
      0.002   17.7   0.9      0.085   12.5   0.1    2.3  2  LBP_BPI_CETP     LBP / BPI / CETP family, N-terminal domain
  ------ inclusion threshold ------
      0.029   14.3   0.1      0.067   13.1   0.1    1.6  1  Cytokin_check_N  Cdc14 phosphatase binding protein N-terminus


Domain annotation for each model (and alignments):
>> Ribosomal_S3Ae  Ribosomal S3Ae family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.8   9.2   1.3e-36   7.6e-33      36     202 .]      76     252 ..      62     252 .. 0.91

  Alignments for each domain:
  == domain 1  score: 113.8 bits;  conditional E-value: 1.3e-36
                     --BSSSESHHSHTT-EEEEESHHHHTCS.HTSSSEEEEEEEEEEE.SSEEEEEEEEEEE-HHHHHHH--SSB-EEEEEEEEEESSSEEEEEEEEE CS
  Ribosomal_S3Ae  36 rtqgtkiaseklkgrvvevslaDLtnde.keqafrklklkieevq.gknaltnFkgmeltrDklrslvrkwsslIeaivdvktkDgyllrvfvva 128
                     +t ++  + ek+ +r++evs  D+  +  +e  +  + lki+++   ++a t+F+g +lt+Dkl  l+++ +s+I+ +++ k  Dgy++r+f++a
      EFC36301.1  76 KTVNHTPTFEKVLNRTLEVSAPDIMPSIkEEMNYNIVNLKINNIPiPQHADTEFNGFRLTKDKLATLTKRFHSTITLNHEFKSLDGYKIRIFMIA 170
                     44445566899************99888777889999******973679********************************************** PP

                     EE-ST.T.....B---HHHHHHHHHHHHHHHHHHHHHS-HHHHHHHHTT.THHHHHHHHHHTTTS-EE.EEEEEEEEEEE-S CS
  Ribosomal_S3Ae 129 fTkkr.n.....sYakssqkkaIrkkmveilteeaseldlkelvkklip.eslgkeiekeakkIyplr.nveirKvkvlkkP 202
                      T+ +       sYa++sq+k+Ir +m++++++++s++++ e+v+++     +++ei+ ++++Iypl+ +++i+K+kvl+kP
      EFC36301.1 171 STRMKaLqfkktSYANKSQIKKIRTVMTDVISKKISQMKILEFVERMAIkCGMSNEIRTRCENIYPLEeEIHITKIKVLEKP 252
                     ***995379*************************************976556***************737**********98 PP

>> LBP_BPI_CETP  LBP / BPI / CETP family, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.1   1.4e-05     0.085      11      53 ..      86     123 ..      83     130 .. 0.89
   2 !    3.7   0.1    0.0073        43       9      47 ..     197     247 ..     189     254 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.4e-05
                   HHHHHHHHTS-CCCEEEEEEETTTECEEEEEEEEEEEEEEEEE CS
  LBP_BPI_CETP  11 kvlqkeleklqlpdilgeekikllgkvkynisnlkIsnlqlps 53 
                   kvl+++le ++ pdi+ ++k++    ++yni nlkI+n  +p+
    EFC36301.1  86 KVLNRTLE-VSAPDIMPSIKEE----MNYNIVNLKINNIPIPQ 123
                   67888888.***********66....79**********99998 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0073
                   HHHHHHHHHHTS-CCCEEEEEEETTTE.............CEEEEEEEEEEE CS
  LBP_BPI_CETP   9 glkvlqkeleklqlpdilgeekikllg.............kvkynisnlkIs 47 
                    ++v+ k++ +++++++++ ++ik  g             +++++i+  kI+
    EFC36301.1 197 MTDVISKKISQMKILEFVERMAIKC-GmsneirtrceniyPLEEEIHITKIK 247
                   5678999***************997.45998888888666444444444443 PP

>> Cytokin_check_N  Cdc14 phosphatase binding protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   1.1e-05     0.067      17      41 ..     223     247 ..     209     250 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.1e-05
  Cytokin_check_N  17 lseeiverfkklYPdeeeleIlslq 41 
                      +s+ei +r++ +YP eee++I +++
       EFC36301.1 223 MSNEIRTRCENIYPLEEEIHITKIK 247
                      689******************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1034  (0.0576719); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1480.67
//
Query:       EFC36302.1  [L=144]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-25   89.8   0.1    1.5e-25   89.6   0.1    1.0  1  PhoPQ_related  PhoPQ-activated pathogenicity-related protein
  ------ inclusion threshold ------
       0.04   13.8   0.0      0.052   13.5   0.0    1.2  1  DUF736         Protein of unknown function (DUF736)


Domain annotation for each model (and alignments):
>> PhoPQ_related  PhoPQ-activated pathogenicity-related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   89.6   0.1   1.7e-29   1.5e-25      51     182 ..       2     143 ..       1     144 [] 0.87

  Alignments for each domain:
  == domain 1  score: 89.6 bits;  conditional E-value: 1.7e-29
  PhoPQ_related  51 kltivvPkekkleetalllisggs......nenvkkkskesesetlaeiaretkavvaelsdvPnqpltfeddgk..arkEDdlvAytwrkfleee 138
                    +l++++P + k+++++l +is+g         +  ++s+ + + ++ + a +tk+v+a ++ vPnqp++++ d++  +r ED++++y w++fl+++
     EFC36302.1   2 NLDLIIPLN-KNNRESLFFISNGDnnlavpGATDLTASPIHVPTFVYDTAVSTKSVTAIVYMVPNQPMSYNSDPThaTRVEDAIIGYGWNRFLQNT 96 
                    58999****.999999999999986666654455567777889999**************************98755799**************76 PP

  PhoPQ_related 139 kdetl..plllpmtkaavraMdlvqeflkel.klkiekFvvsGaSKR 182
                    ++++l  + +lp++k    aMd+v +f+k++ +  ie+F+vsGaSKR
     EFC36302.1  97 TKANLlyVTQLPQVKGNKMAMDTVVSFVKKQtNHVIENFTVSGASKR 143
                    6666422689*******************998999***********9 PP

>> DUF736  Protein of unknown function (DUF736)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   5.8e-06     0.052      15      62 ..      50      97 ..      43     130 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.8e-06
      DUF736 15 eirtltldaklrlvpaekkdsenaPdyrvlagdgveiGaaWkktsee.a 62
                +++t +++a + +vp++  + ++ P++   ++ ++ iG +W++  ++  
  EFC36302.1 50 AVSTKSVTAIVYMVPNQPMSYNSDPTHATRVE-DAIIGYGWNRFLQNtT 97
                6899999*************************.99********998842 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (144 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       428  (0.0238719); expected 358.6 (0.02)
Passed bias filter:                      286  (0.0159518); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.47
# Mc/sec: 923.91
//
Query:       EFC36303.1  [L=234]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.27   11.2   1.4       0.32   11.0   1.4    1.2  1  Mucin     Mucin-like glycoprotein


Domain annotation for each model (and alignments):
>> Mucin  Mucin-like glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   1.4   1.8e-05      0.32       5      28 ..       7      31 ..       1     109 [. 0.71

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.8e-05
       Mucin  5 rlLcalLvlaLcCCasvCvtang.e 28
                r L+a  +l Lc C + C++  + e
  EFC36303.1  7 RTLVAFAFLLLCACMCACARIRElE 31
                88999*************9988752 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (234 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      274  (0.0152825); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 1434.95
//
Query:       EFC36304.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-10   39.8   1.5    1.2e-09   38.5   1.5    1.8  1  TLD       TLD


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.5   1.5   6.8e-14   1.2e-09       1     112 [.      64     175 ..      64     231 .. 0.75

  Alignments for each domain:
  == domain 1  score: 38.5 bits;  conditional E-value: 6.8e-14
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnk.kfygdsesflfsl.spkfkvyks...tgknkaylntssdglgfGggqp 94 
                 l++++s+dg+s  ++ +++e++g +++++k++++++fG+++++ +k +++  +++d+esf f + ++++ +++    ++  + y ++s + ++fG    
  EFC36304.1  64 LIFRASRDGFSEVEFRKRCEDQGKIVIIVKSKGGDLFGGYTKETLKLDQRgSNVKDEESFTFRFdDNTLYIFRLmhdHNIHALYRYSSLYLFAFG---- 158
                 69*******************************************7666657999*********9888888988533333366667777779999.... PP

         TLD  95 kfsLwidsslekgtsrhs 112
                  + +w+ ++ +++t ++s
  EFC36304.1 159 -YCFWVCGDANTSTYSSS 175
                 .67777777777655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       381  (0.0212505); expected 358.6 (0.02)
Passed bias filter:                      311  (0.0173462); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1506.43
//
Query:       EFC36305.1  [L=717]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.7e-24   84.8   1.6      3e-11   43.8   0.7    4.7  4  Ank_2          Ankyrin repeats (3 copies)
    8.5e-19   65.7   3.0      0.011   16.2   0.2    7.4  8  Ank_3          Ankyrin repeat
    2.3e-17   62.8   2.0      0.059   13.7   0.1    6.3  6  Ank_5          Ankyrin repeats (many copies)
    1.2e-16   60.6   0.1    3.2e-16   59.3   0.1    1.8  1  U-box          U-box domain
    8.5e-16   58.1   1.3     0.0022   18.5   0.1    5.3  6  Ank_4          Ankyrin repeats (many copies)
    6.1e-13   48.6   0.8    0.00067   20.0   0.3    5.1  5  Ank            Ankyrin repeat
     0.0062   16.3   0.0      0.023   14.5   0.0    2.0  1  zf-Nse         Zinc-finger of the MIZ type in Nse subunit
  ------ inclusion threshold ------
      0.011   15.9   0.0      0.032   14.4   0.0    1.8  1  zf-NOSIP       Zinc-finger of nitric oxide synthase-interacti
      0.042   13.4   1.1       0.14   11.8   1.1    1.9  1  PI3K_P85_iSH2  Phosphatidylinositol 3-kinase regulatory subun


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0056        11      12      47 ..     201     235 ..     158     247 .. 0.61
   2 !   29.4   0.2   4.4e-10   8.9e-07      25      80 ..     320     384 ..     295     387 .. 0.80
   3 !   43.8   0.7   1.5e-14     3e-11       3      82 ..     327     425 ..     325     426 .. 0.79
   4 !   27.9   0.0   1.4e-09   2.7e-06       8      83 .]     539     638 ..     527     638 .. 0.71

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0056
       Ank_2  12 lvklLlegadpnkngktaLhyAakng.nleivklLle 47 
                 lvk  l+g++  + g+ ++h+A+  + ++e+ + L+ 
  EFC36305.1 201 LVKKSLFGTN--SRGLQPIHTACFFNeSEELFRELIR 235
                 2222222222..2466666666664423355566654 PP

  == domain 2  score: 29.4 bits;  conditional E-value: 4.4e-10
       Ank_2  25 ngktaLhyAakngnleivklLleh........adndgrtpLhyAarsghleivklLlek.gadin 80 
                 +g + + yA+k++ l++vk +le+        +dn+ +tpL  A+  g +++vk+L++  ++d++
  EFC36305.1 320 QGVSLINYACKYNRLHLVKKMLEKsnidvnlhVDNYYHTPLTSAVLGGAFNVVKYLIDEvKVDVE 384
                 7889999***************96667766667799*********99**********65466665 PP

  == domain 3  score: 43.8 bits;  conditional E-value: 1.5e-14
       Ank_2   3 lAakngnlelvklLl..egadpn...k.ngktaLhyAakngnleivklLleh.........ad....ndgr.tpLhyAarsghleivklLlekgadinl 81 
                 +A+k++ l+lvk +l  ++ d+n   +   +t+L  A+ +g  ++vk+L+++          +    +d   ++Lh+A+  gh++i+ +L+ +ga++n+
  EFC36305.1 327 YACKYNRLHLVKKMLekSNIDVNlhvDnYYHTPLTSAVLGGAFNVVKYLIDEvkvdveareSEtqsrRD-FpSALHLAILRGHFDIAHFLISRGANMNA 424
                 89**9989*******5544555575526779*******************9666665554411444344.359******************99***998 PP

       Ank_2  82 k 82 
                 +
  EFC36305.1 425 T 425
                 6 PP

  == domain 4  score: 27.9 bits;  conditional E-value: 1.4e-09
       Ank_2   8 gnlelvklLleg........adpn..k.ngktaLhyAakngnleivklLleh............ad...ndgrtpLhyAarsghleivklLlekgadin 80 
                 g +++++++l++        a  n  + n+++ Lh+   +g +e++++ +++            ++    +  tpLh+A++ g+ +i+  L++ gadi 
  EFC36305.1 539 GCDQIFEWILNHfysdrqklA--NlrDkNKNNMLHWISGYGRVEMLEIAISYmsedssmdvhvmMNqknLSSDTPLHVASQLGRKDICTKLIDLGADIR 635
                 444688888844333333222..23325899*************98888875555566555566224334488*******99**********99****9 PP

       Ank_2  81 lkd 83 
                 +++
  EFC36305.1 636 VRN 638
                 875 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       8.5   1.7e+04       7      23 ..     164     182 ..     161     183 .. 0.67
   2 ?    2.9   0.0      0.12   2.3e+02       2      23 ..     213     235 ..     212     239 .. 0.86
   3 !   11.8   0.0   0.00014      0.28       2      30 ..     321     349 ..     320     350 .. 0.93
   4 !   10.2   0.0    0.0005         1       2      30 ..     356     384 ..     355     385 .. 0.90
   5 !   16.2   0.2   5.5e-06     0.011       4      28 ..     398     421 ..     397     424 .. 0.92
   6 ?   -3.6   0.0         9   1.8e+04      15      25 ..     541     551 ..     538     554 .. 0.70
   7 ?    3.8   0.0      0.06   1.2e+02       2      23 ..     566     587 ..     565     597 .. 0.84
   8 !   13.1   0.0   5.5e-05      0.11       4      30 ..     610     635 ..     608     636 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 8.5
       Ank_3   7 hlAarsgnle..ivkfLle 23 
                 hl ++  n e  i+k L+e
  EFC36305.1 164 HLLCETPNAEskILKSLIE 182
                 6777777775557887776 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.12
       Ank_3   2 GetpLhlAarsgnle.ivkfLle 23 
                 G  p+h+A+ ++  e + + L++
  EFC36305.1 213 GLQPIHTACFFNESEeLFRELIR 235
                 6679**********779999998 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 0.00014
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 G +++ +A+++++l +vk +le+ ++dvn
  EFC36305.1 321 GVSLINYACKYNRLHLVKKMLEKSNIDVN 349
                 678999**********************9 PP

  == domain 4  score: 10.2 bits;  conditional E-value: 0.0005
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 + tpL  A++ g +++vk+L+++  +dv 
  EFC36305.1 356 YHTPLTSAVLGGAFNVVKYLIDEVKVDVE 384
                 68********************8888875 PP

  == domain 5  score: 16.2 bits;  conditional E-value: 5.5e-06
       Ank_3   4 tpLhlAarsgnleivkfLlenkgad 28 
                 ++LhlA++ g+++i++fL+  +ga+
  EFC36305.1 398 SALHLAILRGHFDIAHFLIS-RGAN 421
                 79******************.9998 PP

  == domain 6  score: -3.6 bits;  conditional E-value: 9
       Ank_3  15 leivkfLlenk 25 
                   i +++l+++
  EFC36305.1 541 DQIFEWILNHF 551
                 45899999965 PP

  == domain 7  score: 3.8 bits;  conditional E-value: 0.06
       Ank_3   2 GetpLhlAarsgnleivkfLle 23 
                  +++Lh+   +g++e+++  + 
  EFC36305.1 566 KNNMLHWISGYGRVEMLEIAIS 587
                 6899***********9887665 PP

  == domain 8  score: 13.1 bits;  conditional E-value: 5.5e-05
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 tpLh+A   g+ +i+  L++  gad++
  EFC36305.1 610 TPLHVASQLGRKDICTKLID-LGADIR 635
                 9*******************.****97 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.53   1.1e+03      12      25 ..     209     222 ..     202     242 .. 0.69
   2 !   13.7   0.1     3e-05     0.059      16      53 ..     321     360 ..     314     361 .. 0.92
   3 !    9.2   0.0   0.00077       1.5      12      49 ..     356     390 ..     349     396 .. 0.82
   4 !   13.7   0.1   2.9e-05     0.059      18      47 ..     398     427 ..     381     435 .. 0.79
   5 !   10.1   0.0   0.00039      0.78       8      36 ..     558     586 ..     554     599 .. 0.86
   6 !   12.0   0.0    0.0001       0.2      14      46 ..     606     638 ..     594     642 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.53
       Ank_5  12 ldgggntpLhvAak 25 
                 ++ +g  p+h+A+ 
  EFC36305.1 209 TNSRGLQPIHTACF 222
                 67778889999986 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 3e-05
       Ank_5  16 gntpLhvAakygaadvvrlLl.argadlnltdsrG.ltal 53 
                 g++ +++A+ky+++ +v+++l + + d nl  +++  t+l
  EFC36305.1 321 GVSLINYACKYNRLHLVKKMLeKSNIDVNLHVDNYyHTPL 360
                 7899**************************9999989997 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00077
       Ank_5  12 ldgggntpLhvAakygaadvvrlLl.argadlnltdsrG 49 
                 +     tpL  A+ +ga++vv++L+ +  +d  +++s+ 
  EFC36305.1 356 YH----TPLTSAVLGGAFNVVKYLIdEVKVDVEARESET 390
                 33....9******************98888888888775 PP

  == domain 4  score: 13.7 bits;  conditional E-value: 2.9e-05
       Ank_5  18 tpLhvAakygaadvvrlLlargadlnltds 47 
                 ++Lh+A+ +g++d++ +L+ rga+ n+t++
  EFC36305.1 398 SALHLAILRGHFDIAHFLISRGANMNATCK 427
                 79*****************66666666554 PP

  == domain 5  score: 10.1 bits;  conditional E-value: 0.00039
       Ank_5   8 dvnrldgggntpLhvAakygaadvvrlLl 36 
                   n +d+++n+ Lh+ + yg+ +++++ +
  EFC36305.1 558 LANLRDKNKNNMLHWISGYGRVEMLEIAI 586
                 5689999999***************9987 PP

  == domain 6  score: 12.0 bits;  conditional E-value: 0.0001
       Ank_5  14 gggntpLhvAakygaadvvrlLlargadlnltd 46 
                   + tpLhvA+  g+ d++ +L++ gad+++++
  EFC36305.1 606 LSSDTPLHVASQLGRKDICTKLIDLGADIRVRN 638
                 4444***************************98 PP

>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.3   0.1   1.6e-19   3.2e-16       3      71 ..      28      95 ..      26      97 .. 0.95

  Alignments for each domain:
  == domain 1  score: 59.3 bits;  conditional E-value: 1.6e-19
                GGGB-TTT-SB-SSEEEETTTEEEEHHHHHHHHTT.SSB-TTT-SB--GGGSEE-HHHHHHHHHHHHHC CS
       U-box  3 defldpitlelmkdPvilpsgvvvdrstiekhllsrdktdPftrepltqdqlipnlelKekIdefleek 71
                d   +pit+ +m+dPv+++ g +++r++ie++l +  +t+P t e+l++++l  n ++K++Id fle++
  EFC36305.1 28 DLIYCPITRRIMCDPVVTALGDTFEREAIEEWLVR-RQTNPTTGEQLPNSNLSFNKTVKQMIDVFLETN 95
                5668*******************************.9*****************************987 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.021        42      14      53 ..     195     232 ..     175     234 .. 0.74
   2 !   18.5   0.1   1.1e-06    0.0022       4      55 .]     324     376 ..     321     376 .. 0.93
   3 !   15.6   0.0   9.2e-06     0.018       3      30 ..     398     425 ..     391     438 .. 0.82
   4 ?    3.9   0.0     0.043        85       3      53 ..     525     584 ..     523     586 .. 0.83
   5 !   12.2   0.0    0.0001      0.21       5      55 .]     570     628 ..     566     628 .. 0.82
   6 !    8.3   0.0    0.0018       3.5       3      30 ..     610     637 ..     608     640 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.021
       Ank_4  14 lelvrlLlekgadinaqdnrsGetalhiAakrg.nveilkl 53 
                 +++v+ L+ k  ++  + n++G+ ++h A+ ++ + e ++ 
  EFC36305.1 195 MPSVKDLVKK--SLFGT-NSRGLQPIHTACFFNeSEELFRE 232
                 5556666643..44456.999*********88757776665 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 1.1e-06
       Ank_4   4 aLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55 
                 ++ ya++++rl lv+  lek ++d+n   +++  t+l  A+++g ++++k+L+
  EFC36305.1 324 LINYACKYNRLHLVKKMLEKsNIDVNLHVDNYYHTPLTSAVLGGAFNVVKYLI 376
                 6679**************9979****998999********************8 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 9.2e-06
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaq 30 
                 +aLh a+  g+++++++L+++ga+ na+
  EFC36305.1 398 SALHLAILRGHFDIAHFLISRGANMNAT 425
                 5788888888888888888888888887 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.043
       Ank_4   3 taLhyaai.....sgrlelvrlLlekgad.....inaqdnrsGetalhiAakrgnveilkl 53 
                 +++  a+      +g+ ++ +++l++  +      n + +++ ++ lh     g+ve+l+ 
  EFC36305.1 525 EPIWFAIRtignkQGCDQIFEWILNHFYSdrqklANLR-DKNKNNMLHWISGYGRVEMLEI 584
                 567677777778899999999***99866688889999.9********9999999999975 PP

  == domain 5  score: 12.2 bits;  conditional E-value: 0.0001
       Ank_4   5 LhyaaisgrlelvrlLl.....ekgadinaq...dnrsGetalhiAakrgnveilklLl 55 
                 Lh+   +gr+e++++ +     ++ +d++     +n s +t+lh A + g+++i   L+
  EFC36305.1 570 LHWISGYGRVEMLEIAIsymseDSSMDVHVMmnqKNLSSDTPLHVASQLGRKDICTKLI 628
                 899999***********767655677755555556************999999987775 PP

  == domain 6  score: 8.3 bits;  conditional E-value: 0.0018
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaq 30 
                 t+Lh a + gr +++  L++ gadi  +
  EFC36305.1 610 TPLHVASQLGRKDICTKLIDLGADIRVR 637
                 89**********************9776 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0         5     1e+04       5      22 ..     216     234 ..     213     237 .. 0.74
   2 ?   -0.8   0.0       1.3   2.6e+03       6      29 ..     325     350 ..     320     353 .. 0.71
   3 ?    5.6   0.0     0.012        24       3      27 ..     357     383 ..     355     388 .. 0.75
   4 !   20.0   0.3   3.4e-07   0.00067       4      30 ..     398     425 ..     398     427 .. 0.92
   5 !   16.3   0.0   4.9e-06    0.0097       3      30 ..     609     637 ..     609     638 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 5
                 HHHHHH.HHTTHHHHHHHH CS
         Ank   5 PLHlAa.tngkkriiklLL 22 
                 P H A+  n +++  ++L+
  EFC36305.1 216 PIHTACfFNESEELFRELI 234
                 8999997666677777776 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.3
                 HHHHHHHTTHHHHHHHH.TT.TSTTC CS
         Ank   6 LHlAatngkkriiklLL.hG.Anlna 29 
                   +A+ ++ ++ +k  L ++  ++n+
  EFC36305.1 325 INYACKYNRLHLVKKMLeKSnIDVNL 350
                 55899999888998888743366775 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.012
                 BBHHHHHHHHTTHHHHHHHHTT..TST CS
         Ank   3 nTPLHlAatngkkriiklLLhG..Anl 27 
                 +TPL  A+ +g  +++k+L++    ++
  EFC36305.1 357 HTPLTSAVLGGAFNVVKYLIDEvkVDV 383
                 6*******777788*****94322555 PP

  == domain 4  score: 20.0 bits;  conditional E-value: 3.4e-07
                 BHHHHHHHHTTHHHHHHHH.TTTSTTCB CS
         Ank   4 TPLHlAatngkkriiklLL.hGAnlnal 30 
                 ++LHlA+ +g+ +i+++L+ +GAn na+
  EFC36305.1 398 SALHLAILRGHFDIAHFLIsRGANMNAT 425
                 69*****99**********779****97 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 4.9e-06
                 BBHHHHHHHHTTHHHHHHHHT.TTSTTCB CS
         Ank   3 nTPLHlAatngkkriiklLLh.GAnlnal 30 
                 +TPLH+A++ g k+i+  L++ GA++  +
  EFC36305.1 609 DTPLHVASQLGRKDICTKLIDlGADIRVR 637
                 6******************966***8655 PP

>> zf-Nse  Zinc-finger of the MIZ type in Nse subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   1.2e-05     0.023      13      48 ..      31      65 ..      27      72 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.2e-05
                B-TTTSSB-SSEEEESSS--EEEHHHHHHHCTTTS- CS
      zf-Nse 13 kCPltlqpfeePvtskkCpHvFEreaIlelikrkkt 48
                 CP+t++ + +Pv   +   +FEreaI+e + r++t
  EFC36305.1 31 YCPITRRIMCDPVVT-ALGDTFEREAIEEWLVRRQT 65
                6************85.6688**********955544 PP

>> zf-NOSIP  Zinc-finger of nitric oxide synthase-interacting protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.0   1.6e-05     0.032      35      72 ..      24      61 ..      11      64 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.6e-05
    zf-NOSIP 35 davkdfdccslslqacrdpvltedgylyekeaileyil 72
                + +kd+  c ++ +   dpv+t  g  +e+eai e+++
  EFC36305.1 24 NPIKDLIYCPITRRIMCDPVVTALGDTFEREAIEEWLV 61
                679******************************99886 PP

>> PI3K_P85_iSH2  Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.1   6.9e-05      0.14      56     122 ..     222     296 ..     175     309 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 6.9e-05
  PI3K_P85_iSH2  56 aFneaikmFeeqiklqekfskeaq......ehEie..klqenleqlksrlkelhsskekLeedlkqqkeeerele 122
                     Fne +++F+e i+lq++++ +++      +hE+   + ++n+ +l  +l       ++L+ +  +++++e+el+
     EFC36305.1 222 FFNESEELFRELIRLQDEYETQYEssvislQHENLdpRCKKNMYLLMFKLIITSTPHNSLSSKSFETVQKEQELN 296
                    6**********************6455555666544678888888888887777777777777777777777764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (717 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       657  (0.0366445); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.76u 0.28s 00:00:01.04 Elapsed: 00:00:00.48
# Mc/sec: 4448.91
//
Query:       EFC36306.1  [L=813]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.1e-14   52.2   0.0    2.3e-13   50.5   0.0    2.0  1  RNase_H          RNase H
    1.4e-05   24.9   0.8    1.4e-05   24.9   0.8    2.5  3  Exo_endo_phos_2  Endonuclease-reverse transcriptase
  ------ inclusion threshold ------
      0.014   15.2   0.0       0.05   13.4   0.0    2.0  2  RVT_3            Reverse transcriptase-like
      0.062   12.8   0.0       0.13   11.7   0.0    1.5  1  Exo_endo_phos    Endonuclease/Exonuclease/phosphatase family
       0.15   11.0   0.0       0.31    9.9   0.0    1.4  1  Activator_LAG-3  Transcriptional activator LAG-3
        3.1    8.3   5.5         33    5.0   0.2    3.8  4  HTH_40           Helix-turn-helix domain


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.5   0.0   7.8e-17   2.3e-13       4     142 ..     476     602 ..     473     603 .. 0.77

  Alignments for each domain:
  == domain 1  score: 50.5 bits;  conditional E-value: 7.8e-17
                 EEEEEEEEEECTTTCEEEEE.EECTT......EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSB CS
     RNase_H   4 vvvYtDGsclgnpgeggaga.vlykeg....arnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkp 97 
                  +++tDGs l   g+ g+g+ +++++g     + +s +++++ +nn aE+ A+i+a+k l  +++  i tDSk +++ +++     k ++     ++ p
  EFC36306.1 476 FIIHTDGSKL--AGKTGMGInIYESGGrlspCKSLSLRINNEYSNNVAEIGAIITAMKLLPNGTTARIHTDSKVAID-VLS--R--KYKG-----NFLP 562
                 589*****66..9999****555555477444478888889*****************999****************.554..1..2222.....2334 PP

                 HTTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHHH CS
     RNase_H  98 vknkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkeaa 142
                 +k  + +++     k+ +v++ +vkgH+    +N  +DrlAk++ 
  EFC36306.1 563 FKT-EFFNIQ--KEKNISVYIIKVKGHEDK--ENIIVDRLAKDGT 602
                 444.333333..346899**********98..8*********986 PP

>> Exo_endo_phos_2  Endonuclease-reverse transcriptase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.8   4.8e-09   1.4e-05      15     118 ..      52     151 ..      34     152 .. 0.77
   2 ?   -3.3   0.1       2.7     8e+03      43      77 ..     160     192 ..     159     206 .. 0.61
   3 ?   -2.3   0.1       1.3   3.9e+03      44      70 ..     677     706 ..     674     735 .. 0.69

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 4.8e-09
  Exo_endo_phos_2  15 enlestlekllselkspkiiilGDfNakhplWgsedtdssargeeLiefleehslsllnllksgptfkssng....sstiDltltsdnlalskl 104
                       ++ +++++++ +++++++ii GD+N   ++ ++       r +e   +++  +l+    +++ +t++++++    +s +D +++s+++ + k+
       EFC36306.1  52 VEAMNSITNAVLTCRDEHVIINGDLNINTINPSN------GRDKEWCWLFNLLQLT--EYKTNNKTYIRRQQnritTSRLDHIFVSKDIKVIKE 137
                      45567788888888878*************9988......5566666666666666..6666667777777667789***************** PP

  Exo_endo_phos_2 105 eleeedlgSDHrpi 118
                      el ++ ++ DH p 
       EFC36306.1 138 ELLPPLTSNDHIPF 151
                      ***********986 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.7
  Exo_endo_phos_2  43 hplWgsedtdssargeeLiefleehslsllnllks 77 
                      h +W s   +  ++ ee+i+ +++ + +++++l+ 
       EFC36306.1 160 HLNWRSYIGK--KKREEMIKEINTSNANTFQELNA 192
                      6677775544..66777777777766666665554 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.3
  Exo_endo_phos_2  44 plWgsedtds...sargeeLiefleehsls 70 
                      + W + +++    +++ +eL  ++ ++++ 
       EFC36306.1 677 QIWRNASNSHikyTQKKDELNPTCSDCNCP 706
                      567775555577778888888777777765 PP

>> RVT_3  Reverse transcriptase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.3   0.1         5   1.5e+04      69      92 ..     257     278 ..     251     284 .. 0.63
   2 ?   13.4   0.0   1.7e-05      0.05       2      79 ..     480     555 ..     479     565 .. 0.87

  Alignments for each domain:
  == domain 1  score: -4.3 bits;  conditional E-value: 5
       RVT_3  69 sktvvqllngrekvksselanlld 92 
                 +k++ ++l+++   ++s+++++++
  EFC36306.1 257 CKEIKEQLTDKY--NNSHASHMYQ 278
                 455556666665..5666666665 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 1.7e-05
       RVT_3   2 fdgafkkksgaggagvvirdsnGevllagaek..lqgkasveeAElqALlrGLqlalklgirrlvvegDsktvvqllngr 79 
                 +dg  +k  g++g+g+ i +s G++  + + +  +++ +s+ +AE  A++ +++l  + +  r++  +Dsk+ +++l+++
  EFC36306.1 480 TDG--SKLAGKTGMGINIYESGGRLSPCKSLSlrINNEYSNNVAEIGAIITAMKLLPNGTTARIH--TDSKVAIDVLSRK 555
                 688..8899999***********998777766669*************************99986..7999999888876 PP

>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   4.4e-05      0.13     143     220 ..      66     144 ..      49     156 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.4e-05
                    TTSEEEEEEE-SSSTSGGGBSCGHHHHHHCTTTHH........SSCESCETTTTTTTTTTTEB-BEEEEEECHHHCCEEEEEEECC CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 143 rgapvivaGDfNarpsdddsrvlrtrglalapapv........glyllgggptptyvtraggsrlDrilaspalalfrsgvlpppl 220
                    r+++vi+ GD+N        + +++  +++ ++ +        +  +++ ++     +r ++srlD+i++s++ +++  + lpp+ 
     EFC36306.1  66 RDEHVIINGDLNI-------NTINPSNGRDKEWCWlfnllqltEYKTNNKTYIRRQQNRITTSRLDHIFVSKDIKVIKEELLPPLT 144
                    5789999999999.......333333333333322456777877777777777777788888999***********9999999875 PP

>> Activator_LAG-3  Transcriptional activator LAG-3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00011      0.31     199     262 ..     312     375 ..     262     383 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00011
                      XXXXXXXXXXXXXXXXXXXX.XXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Activator_LAG-3 199 vptpassihrpspaemrsvc.glsrna..tldltcsplsgglpivdenslavpegewfdklalavae 262
                        tp      psp+ + s+   + r +   +  t+  + +  p  de sl++ +g  ++klal+v e
       EFC36306.1 312 NQTP---TFMPSPSTITSGPrDIGRISyrDVKETIKRMKSNTPGQDEISLDIIKGLKLEKLALIVEE 375
                      4444...45688888887752344544004556899***************************9977 PP

>> HTH_40  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1     0.036   1.1e+02      39      80 ..     157     198 ..     114     203 .. 0.81
   2 ?    5.0   0.2     0.011        33      51      81 ..     239     269 ..     221     272 .. 0.88
   3 ?   -1.7   0.1       1.4   4.1e+03      52      79 ..     588     617 ..     570     652 .. 0.54
   4 ?   -2.1   0.0       1.8   5.4e+03      28      63 ..     634     648 ..     616     691 .. 0.49

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.036
      HTH_40  39 egeeidlerlvseeeekeIeeaiekvgseklkpikealpeev 80 
                  +  ++++ ++ +++++e+++ i+  + + ++++ ++ ++++
  EFC36306.1 157 FKSHLNWRSYIGKKKREEMIKEINTSNANTFQELNAEIQNNI 198
                 3456999******99999999***999999999998887766 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.011
      HTH_40  51 eeeekeIeeaiekvgseklkpikealpeevs 81 
                  +e++e+++++++   ++ k+ike+l +++ 
  EFC36306.1 239 LDEISELQTILKETHIQSCKEIKEQLTDKYN 269
                 578999999****9999*********99985 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.4
      HTH_40  52 eeekeIeeaiekvgsek..lkpikealpee 79 
                 ++e+ I + ++k g+e+  + +ik  l ++
  EFC36306.1 588 DKENIIVDRLAKDGTERdkIFDIKSLLTNQ 617
                 444444444444333322244444444333 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 1.8
      HTH_40  28 TIegHLaelieegeeidlerlvseeeekeIeeaiek 63 
                 T+ + L e+ e+                     i+ 
  EFC36306.1 634 TVNRQLKEMHEA---------------------IDS 648
                 333333333333.....................333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1217  (0.0678789); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.47
# Mc/sec: 5156.42
//
Query:       EFC36307.1  [L=546]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.039   14.4   1.5         12    6.4   1.1    3.3  2  Inhibitor_I29  Cathepsin propeptide inhibitor domain (I29)


Domain annotation for each model (and alignments):
>> Inhibitor_I29  Cathepsin propeptide inhibitor domain (I29)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0    0.0023        41       3      42 ..      39     102 ..      37     185 .. 0.74
   2 ?    6.4   1.1   0.00066        12      23      49 ..     369     394 ..     361     410 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0023
  Inhibitor_I29   3 swmdkygkkY........................rhsseinerfenFkeNlrqiqehNanknvt 42 
                    ++m+  +k Y                        +++s +n+  ++Fk+   +iq+  +++++ 
     EFC36307.1  39 KYMETMQKIYdkimfksefvqdkdvkvkvdninqEDTSTTNISTDSFKKPTSEIQNIKSTPQNR 102
                    6777777777777777777777777788888888999*******************99444443 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.00066
  Inhibitor_I29  23 enFkeNlrqiqehNanknvtftlglNk 49 
                    + F +N+ +i e+  nk++t t++l k
     EFC36307.1 369 KDFNTNQCMITESK-NKSNTTTFKLCK 394
                    669***********.*****9996544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (546 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1576  (0.0879023); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 3161.62
//
Query:       EFC36308.1  [L=311]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.9e-16   59.1   0.1    7.3e-16   58.8   0.1    1.1  1  PAC2      PAC2 family


Domain annotation for each model (and alignments):
>> PAC2  PAC2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.8   0.1   4.1e-20   7.3e-16       1     211 [.      48     294 ..      48     296 .. 0.88

  Alignments for each domain:
  == domain 1  score: 58.8 bits;  conditional E-value: 4.1e-20
                 EEEESSCGGGHHHHHHHHHHHHTTEEEEEEEEHCCHSBCCCC.SEEEEETTEEE-SEEEEEETTT.SEEEEEEE....E-HSCHHHHHHHHHHHHHHHT CS
        PAC2   1 LilGfpgiGnVgqlavdlLiesleaekvgeidsdyllpfvgprpvvlveegrelepprlyakdsgsrdllvlqg....repilqyeefakalldwaeel 95 
                 Li+Gfp+     + a+ +++e+l++  +g + s+  +p     pv l+++ ++ + +r+y ++    +++v+++     +p +  + +++al ++ +++
  EFC36308.1  48 LIEGFPSGATTISTAAGYVVEQLDLPLIGDVISEV-FP-----PVCLINNYTPQSGVRIYGNN----KIVVFTSeyelKDPFVSHQ-MVNALFEFGKRH 135
                 8*********************************9.**.....**999999*********666....8*********888888888.************ PP

                 TESEEEEEEEEEESS-..................................ES..TTS-.EEEEEESSHHHHHHH.HCT......-CEEEEHHHHHHHHH CS
        PAC2  96 gvkevvvLggldager..................................advphtrpekvtgaatdeelleel.ees......eyggivgitglLlsa 153
                 g+k +v L++++  e+                                  +d++ ++ ++++ + +d+e+++ l +        ++ + +gi+++ l+ 
  EFC36308.1 136 GCKCIVSLEAIPMDEKkkrliagedvediqtpihppsreellklltaasnEDTS-DQSDSIYFITNDQEMADTLvK-YghfpikDNIVLSGISSVVLGK 232
                 ************7777******************99999999999988874443.455589999999999999944.33456669999*********** PP

                 HHHTT-EEEEEEEEEECCC..--HHHHHHHHHHHHHHHT--..-HCHHHHHHHHHHHHHHHH CS
        PAC2 154 akergipavgllaevphyl..pdPkaaaalleflskllgle..vdtedLeedaeeleeqlee 211
                 a   ++ +vgl+a+++      + k  ++++++++kllg e  ++t++Le+  e+++ +l+e
  EFC36308.1 233 APFTDLVVVGLFAPISLTQeiLSTKPIISIVHAIDKLLGEElfIKTDKLEKTGEAIRIKLNE 294
                 ***************99643445555678*********9665599**********9999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      501  (0.0279436); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 2009.63
//
Query:       EFC36309.1  [L=361]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.4e-31  109.7   0.0    3.6e-09   36.6   0.0    5.3  6  FRG1       FRG1-like domain
    1.4e-24   86.5   0.0    5.1e-08   33.1   0.0    4.1  4  Fascin     Fascin domain
      7e-09   36.0   0.1    1.1e-08   35.4   0.1    1.3  1  EF-hand_7  EF-hand domain pair
    2.6e-06   26.9   0.3       0.02   14.8   0.0    2.5  2  EF-hand_6  EF-hand domain
    8.5e-06   25.5   0.0        1.3    8.7   0.0    3.7  4  DUF569     Domain of unknown function (DUF569)
    0.00026   20.3   0.1      0.021   14.3   0.0    2.4  2  EF-hand_1  EF hand
  ------ inclusion threshold ------
      0.052   13.4   0.0      0.094   12.6   0.0    1.4  1  EF-hand_8  EF-hand domain pair
       0.18   11.4   0.0       0.44   10.1   0.0    1.6  1  EF-hand_5  EF hand


Domain annotation for each model (and alignments):
>> FRG1  FRG1-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.2       3.1     7e+03     132     147 ..      37      52 ..      21      67 .. 0.48
   2 !    8.4   0.0   0.00071       1.6      42      77 ..     123     158 ..     101     162 .. 0.85
   3 !   22.4   0.0   3.8e-08   8.5e-05      31      81 ..     154     203 ..     151     204 .. 0.89
   4 !   22.6   0.0   3.1e-08     7e-05      35      73 ..     197     235 ..     193     238 .. 0.91
   5 !   18.4   0.0   6.1e-07    0.0014      35      74 ..     238     277 ..     235     281 .. 0.92
   6 !   36.6   0.0   1.6e-12   3.6e-09      39     111 ..     283     355 ..     277     360 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3.1
        FRG1 132 edreklrekeskyvkk 147
                  d+ + + +++k+ kk
  EFC36309.1  37 YDKDHSNSMNKKEWKK 52 
                 3333333333333333 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00071
        FRG1  42 slKsgyGkYlgvdkegilsaraeAisseEqfevvfe 77 
                  l+s + kY+ ++ +g+++a+ +A ++ E  +++  
  EFC36309.1 123 NLRSCHSKYFCIEPSGQVVANRDASGAWEAMTLIHI 158
                 5899*************************9999865 PP

  == domain 3  score: 22.4 bits;  conditional E-value: 3.8e-08
        FRG1  31 tavkvasdekislKsgyGkYlgvdkegilsaraeAisseEqfevvfeegkt 81 
                 t++++ s +  ++Ks +Gk++  + +g ++a+ +A+++ E f +v + +++
  EFC36309.1 154 TLIHI-SGNDYAFKSAHGKFMCAEPSGEIIANRDALGPWETFSLVQSGNQV 203
                 67778.77889*********************************9887665 PP

  == domain 4  score: 22.6 bits;  conditional E-value: 3.1e-08
        FRG1  35 vasdekislKsgyGkYlgvdkegilsaraeAisseEqfe 73 
                 v s +++++Ks +Gk+l  + +g+++a+ +A+++ Eqf+
  EFC36309.1 197 VQSGNQVAFKSAHGKFLCAEPSGLVIANRDALGPWEQFQ 235
                 667899*******************************97 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 6.1e-07
        FRG1  35 vasdekislKsgyGkYlgvdkegilsaraeAisseEqfev 74 
                 +a ++ isl+ ++Gk l  +++  ++a+ +A+++ Eqf+v
  EFC36309.1 238 LAPNQSISLRHHHGKLLCAESNHSMVANRDAVGPWEQFTV 277
                 567899********************************97 PP

  == domain 6  score: 36.6 bits;  conditional E-value: 1.6e-12
        FRG1  39 ekislKsgyGkYlgvdkegilsaraeAisseEqfev.vfeegktallalaketflsvdeekdivakskkaaeee 111
                  k +++s +Gk +  + +g+l+a+ +A+++ Eqf v +  +g  al + +++t++ v++++div++++ ++e e
  EFC36309.1 283 GKNAFRSAHGKLMCAEPSGLLVANRDAVGPWEQFSVeLHGNGAIALKS-EHNTYVCVEPSGDIVVNRSAVGEWE 355
                 5789******************************9978999999**99.******************9999866 PP

>> Fascin  Fascin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   3.8e-06    0.0086      23     107 ..      64     151 ..      45     155 .. 0.84
   2 !   33.1   0.0   2.3e-11   5.1e-08      32     110 ..     159     235 ..     148     236 .. 0.92
   3 !   29.2   0.0   3.8e-10   8.5e-07      31     111 .]     238     318 ..     233     318 .. 0.90
   4 !    6.9   0.0    0.0032       7.1      68     105 ..     315     353 ..     314     358 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.8e-06
                 GGGEEEEEEETTSEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEE...TCEEEEEETTSCEEEECTTTEEEEEESSSSGGG CS
      Fascin  23 kkqlftLefdeesyavaLrshngkYlsldkdGrvvaeaetkeedtlFelefr...grwallresngryLgigkeglLkasastvgkde 107
                  k lf+L+   +s+++ L ++ + Yl ++  G  + + +   ++  ++++     +  a lr+++ +y++i+++g+++a+ ++ g+ e
  EFC36309.1  64 IKFLFKLVDHAKSKSISLSDFINVYLFVTGGGMSYPGTNYSGPHGSYTIHSAkhrSLLANLRSCHSKYFCIEPSGQVVANRDASGAWE 151
                 4568999988899999***********877777777888999*******99864455556899*****************99988765 PP

  == domain 2  score: 33.1 bits;  conditional E-value: 2.3e-11
                 ETTSEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEETCEEEEEETTSCEEEECTTTEEEEEESSSSGGGEEE CS
      Fascin  32 deesyavaLrshngkYlsldkdGrvvaeaetkeedtlFelefrgrwallresngryLgigkeglLkasastvgkdelft 110
                 + + ya  ++s+ gk++ ++ +G++ a+++   +   F+l  +g  +++++ +g++L+++++gl+ a+ +++g+ e f+
  EFC36309.1 159 SGNDYA--FKSAHGKFMCAEPSGEIIANRDALGPWETFSLVQSGNQVAFKSAHGKFLCAEPSGLVIANRDALGPWEQFQ 235
                 445788..******************************************************************99997 PP

  == domain 3  score: 29.2 bits;  conditional E-value: 3.8e-10
                 EETTSEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEE.TCEEEEEETTSCEEEECTTTEEEEEESSSSGGGEEEE CS
      Fascin  31 fdeesyavaLrshngkYlsldkdGrvvaeaetkeedtlFelefr.grwallresngryLgigkeglLkasastvgkdelftl 111
                   +++ ++ Lr h gk l ++++ + va+++   +  +F++e + +++ ++r+ +g+ ++++++glL+a+ ++vg+ e f++
  EFC36309.1 238 LAPNQ-SISLRHHHGKLLCAESNHSMVANRDAVGPWEQFTVEHHgAGKNAFRSAHGKLMCAEPSGLLVANRDAVGPWEQFSV 318
                 44444.448***********************************989999999*************************9985 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0032
                 EEEEEEE.TCEEEEEETTSCEEEECTTTEEEEEESSSSG CS
      Fascin  68 lFelefr.grwallresngryLgigkeglLkasastvgk 105
                 +F++e + ++ ++l++ +  y++++++g+++ + s+vg+
  EFC36309.1 315 QFSVELHgNGAIALKSEHNTYVCVEPSGDIVVNRSAVGE 353
                 6999999889999999999*******9999999999987 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.4   0.1     5e-12   1.1e-08       3      70 ..      29      88 ..      27      89 .. 0.89

  Alignments for each domain:
  == domain 1  score: 35.4 bits;  conditional E-value: 5e-12
   EF-hand_7  3 klkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkly 70
                + +  F+++D+d++++++k e +++ +      + g  l +ee++ lfk +D+ k+ +is+++F + y
  EFC36309.1 29 QAQSTFQQYDKDHSNSMNKKEWKKAAQ------DIG--LAKEEIKFLFKLVDHAKSKSISLSDFINVY 88
                56778******************9999......555..55789*********************9887 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   8.7e-06      0.02       3      27 ..      31      55 ..      29      58 .. 0.88
   2 !    9.7   0.1   0.00038      0.86       1      26 [.      63      88 ..      63      91 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 8.7e-06
   EF-hand_6  3 reaFklfDkdgdGkidaeElrkalr 27
                ++ F+++Dkd++++ +++E++ka +
  EFC36309.1 31 QSTFQQYDKDHSNSMNKKEWKKAAQ 55
                789******************9976 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00038
   EF-hand_6  1 elreaFklfDkdgdGkidaeElrkal 26
                e++ +Fkl D+ ++ +i+ +++++++
  EFC36309.1 63 EIKFLFKLVDHAKSKSISLSDFINVY 88
                68899*****************9975 PP

>> DUF569  Domain of unknown function (DUF569)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0     0.002       4.5      11      67 ..     123     176 ..     116     183 .. 0.72
   2 !    8.3   0.0   0.00077       1.7       7      72 ..     160     221 ..     153     226 .. 0.78
   3 !    8.7   0.0   0.00059       1.3       8      73 ..     242     304 ..     236     310 .. 0.82
   4 ?   -2.0   0.0       1.1   2.5e+03       9      24 ..     325     340 ..     318     353 .. 0.69

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.002
      DUF569  11 rlrsvhdkylvadedeetvrqdrdGsakrakwtvevvekkaelirlkscyGkyltas 67 
                  lrs+h ky+  +   + v+ +rd s         +++ + +   +ks++Gk++ a 
  EFC36309.1 123 NLRSCHSKYFCIEPSGQVVA-NRDASGAWEAM--TLIHISGNDYAFKSAHGKFMCAE 176
                 79*******99987777665.55554433333..445555577889*******9985 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00077
      DUF569   7 akavrlrsvhdkylvadedeetvrqdrdGsakrakwtvevvekkaelirlkscyGkyltasnkpll 72 
                 ++   ++s h k++ a+   e +++ r   +    w    ++++ + + +ks++Gk+l a  + l+
  EFC36309.1 160 GNDYAFKSAHGKFMCAEPSGEIIAN-R---DALGPWETFSLVQSGNQVAFKSAHGKFLCAEPSGLV 221
                 5566788999999999998887764.3...44567888888888999***********99877665 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00059
      DUF569   8 kavrlrsvhdkylvadedeetvrqdrdGsakrakwtvevvekkaelirlkscyGkyltasnkplll 73 
                 +++ lr +h k l a+ ++ ++  +rd      ++tve      +   ++s++Gk + a  + ll+
  EFC36309.1 242 QSISLRHHHGKLLCAESNH-SMVANRDAVGPWEQFTVEHHGAGKNA--FRSAHGKLMCAEPSGLLV 304
                 6789*******99997765.5667899999999*****98877775..579****99998887775 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.1
      DUF569   9 avrlrsvhdkylvade 24 
                 a+ l+s h++y+  + 
  EFC36309.1 325 AIALKSEHNTYVCVEP 340
                 6778888888877664 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   9.5e-06     0.021       3      26 ..      31      54 ..      29      57 .. 0.88
   2 ?    3.7   0.0     0.024        53       1      24 [.      63      86 ..      63      88 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 9.5e-06
                HHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1  3 keiFrefDkDgdGkIdfeEfkell 26
                +  F+ +DkD++  ++++E+k++ 
  EFC36309.1 31 QSTFQQYDKDHSNSMNKKEWKKAA 54
                568******************986 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.024
                HHHHHHHHHTTTSSSEEEHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfke 24
                e+k +F+++D  ++  I++++f++
  EFC36309.1 63 EIKFLFKLVDHAKSKSISLSDFIN 86
                7999*****************987 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   4.2e-05     0.094      21      51 ..      56      87 ..      41      89 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 4.2e-05
   EF-hand_8 21 k.glseeevdilfrefDtdgdGkisfeEFcvl 51
                + gl +ee+  lf+++D  ++  is+ +F+++
  EFC36309.1 56 DiGLAKEEIKFLFKLVDHAKSKSISLSDFINV 87
                26699************************986 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   0.00019      0.44       3      23 ..      32      52 ..      30      53 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00019
                HHHHHH-SS-SSCE-HHHHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeELkt 23
                 tFq+ D++++   +k E+k+
  EFC36309.1 32 STFQQYDKDHSNSMNKKEWKK 52
                69**********999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (361 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2251.82
//
Query:       EFC36310.1  [L=889]
Description: hypothetical protein NAEGRDRAFT_60034 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0088   15.9   0.0      0.035   14.0   0.0    2.1  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.094   12.6   0.0       0.31   10.9   0.0    1.9  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.0   3.9e-06     0.035       5      40 ..     114     149 ..     111     151 .. 0.94

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.9e-06
                 HS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTH CS
       F-box   5 rLPsevlrhILerLplsdllalrrVSkgwrilidsd 40 
                  LPse+l++ + +++   l+++ ++++g+++l d++
  EFC36310.1 114 LLPSEILLDLMFYMDKYALFNFIQTCRGVYDLFDRV 149
                 59*******************************985 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   3.5e-05      0.31       3      35 ..     114     146 ..     112     150 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 3.5e-05
  F-box-like   3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrrva 35 
                  LP EiLl+   y++ + L +  ++Cr  +++ 
  EFC36310.1 114 LLPSEILLDLMFYMDKYALFNFIQTCRGVYDLF 146
                 59*************************999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (889 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       663  (0.0369792); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.30s 00:00:01.05 Elapsed: 00:00:00.49
# Mc/sec: 5422.71
//
Query:       EFC36311.1  [L=315]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.2e-13   49.2   0.0    6.6e-13   48.6   0.0    1.2  1  SBP_bac_3  Bacterial extracellular solute-binding proteins, f


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.6   0.0   3.7e-17   6.6e-13      47     171 ..     133     257 ..     118     275 .. 0.88

  Alignments for each domain:
  == domain 1  score: 48.6 bits;  conditional E-value: 3.7e-17
                 GGGHHHHHHTTSSSEEESSEB--HHHHTTEEEESESEEEEEEEEEEE.TTSHGTCCHSSCGCG..TTSEEEEETTSHHHHHHHHHHHCTSEEEEESSHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3  47 wdelipalksgkvDiaiaaititpeReekvdFsqpyfsagqvllvrk.kdaskissiksladL..kgkkvgvqagstaeellkeelkkgaeivefdtle 142
                 ++++ ++++sg++D++++a+ +++eR ++  F   y ++ q+ l  + ++  ++  +k+++dL   g  ++v+a++++e+++k+++k +a+i++   ++
  EFC36311.1 133 FATMKKGVDSGECDVIVGATNWNAERLAQAHFQCAYGTSYQGWLRSElQN--ETLIFKNIEDLdnTGVIIVVSADTSYENFVKNTFK-KATIKVIGGYD 228
                 788899**************************************998654..4455677778844566999************9876.899999***** PP

                 HHHHHHHTTSSSEEEEEHHHHHHHHHHCC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 143 ealqaLkngrvdavvadspvlaylvkknp 171
                 +a ++++n+ v a++ad   l  ++ +n 
  EFC36311.1 229 DAWAMVSNRTVHAYIADVLDLFIWLGNNR 257
                 *****************998887777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       824  (0.0459591); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 2028.32
//
Query:       EFC36312.1  [L=827]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      1e-06   29.3   0.4    8.5e-06   26.3   0.0    2.7  2  RCC1             Regulator of chromosome condensation (RCC1) 
  ------ inclusion threshold ------
      0.011   15.5   2.7      0.011   15.5   2.7    4.2  5  RCC1_2           Regulator of chromosome condensation (RCC1) 
      0.047   13.4   0.0        0.1   12.3   0.0    1.5  1  Aminoglyc_resit  Aminoglycoside-2''-adenylyltransferase
       0.12   12.4   0.1        6.5    6.8   0.0    2.5  2  MinC_N           Septum formation inhibitor MinC, N-terminal 
       0.42   11.0   2.4        8.5    6.8   0.0    2.7  2  CENP-B_dimeris   Centromere protein B dimerisation domain


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2       0.8   2.9e+03       8      20 ..     403     415 ..     402     423 .. 0.82
   2 !   26.3   0.0   2.4e-09   8.5e-06       2      50 .]     446     492 ..     445     492 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.8
                 E--GGGTTSSSS- CS
        RCC1   8 GrndyGqLGlgtt 20 
                 G+n+ GqL +++t
  EFC36312.1 403 GNNNLGQLACKQT 415
                 99******88655 PP

  == domain 2  score: 26.3 bits;  conditional E-value: 2.4e-09
                 TEEEEEE--GGGTTSSSS---E....EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesv....lvPtkveglsgnrvvkvacGddhtval 50 
                 G+++ +G n+ GqLGlg+ +++     vP+++      ++++ ++G + t+a+
  EFC36312.1 446 GELWVCGDNSCGQLGLGDFNNReafeKVPSRI------PFIDFSSGKNCTFAI 492
                 99*****************777788888****......89***********98 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.033   1.2e+02       4      21 ..     338     355 ..     336     355 .. 0.87
   2 ?   -3.9   1.2       3.9   1.4e+04      24      30 .]     403     409 ..     403     409 .. 0.95
   3 ?   15.5   2.7     3e-06     0.011      11      30 .]     439     458 ..     437     458 .. 0.95
   4 ?    1.8   0.2     0.063   2.3e+02       2      24 ..     480     502 ..     479     503 .. 0.88
   5 ?   -2.1   0.0         1   3.8e+03      19      26 ..     675     682 ..     674     683 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.033
      RCC1_2   4 vsaGdyHscaLtedGeVl 21 
                 +  G+ H  +Lte+++++
  EFC36312.1 338 IFVGYGHVAFLTENNHIY 355
                 668***********9987 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 3.9
      RCC1_2  24 GsNsdGQ 30 
                 G+N+ GQ
  EFC36312.1 403 GNNNLGQ 409
                 9*****9 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 3e-06
      RCC1_2  11 scaLtedGeVlcWGsNsdGQ 30 
                 +c+L + Ge++ +G+Ns+GQ
  EFC36312.1 439 TCILNSMGELWVCGDNSCGQ 458
                 8999999************9 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.063
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWG 24 
                 ++ s+G + ++a+t+  eV+c+G
  EFC36312.1 480 IDFSSGKNCTFAITCLHEVVCCG 502
                 5678899999************9 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 1
      RCC1_2  19 eVlcWGsN 26 
                 +V+c+G N
  EFC36312.1 675 IVRCYGEN 682
                 69****88 PP

>> Aminoglyc_resit  Aminoglycoside-2''-adenylyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   2.8e-05       0.1      66     149 ..     246     333 ..     228     343 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.8e-05
  Aminoglyc_resit  66 gvvteeldygflaeiqdilldcepavridedyeleelpqgscpeeaegvlagklvr..ctsweailwdyfyy..leevpqvewrtkdi 149
                       + +   +y fl  i+++l++c p    + + +l++l + + p  ++ +  g+ v     s e  +w  f      +vp+ + +t +i
       EFC36312.1 246 IKEIYSSSYIFLQTIKNELFECTPISSEELNNDLKNLKKITLPFTPKIIAEGRGVTryYLSTEDEIWASFSVgkFTKVPKKDLPTPNI 333
                      44445679*********************************************9962246999999*999752256888888887665 PP

>> MinC_N  Septum formation inhibitor MinC, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.031   1.1e+02      63      92 ..      37      66 ..      14      79 .. 0.62
   2 ?    6.8   0.0    0.0018       6.5       3      41 ..     624     662 ..     622     670 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.031
      MinC_N 63 aLkelis.raglrivgvsgckdkaskeeimk 92
                 + e++s ++g+ i+gv + + +++k+    
  EFC36312.1 37 DVDEICSsSQGVEIIGVIDHQKEKKKKA-SS 66
                5667775268*******77765555443.33 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0018
      MinC_N   3 qapvelksskltvlvleLhtsdlerikqkLsdkiaeaPk 41 
                  ++++lks  +++l+ +L+  +++ ++  L++k++ a  
  EFC36312.1 624 DTFIQLKSCLVNILIDKLSPLNISTTIECLYEKVQIADD 662
                 6899******************************98865 PP

>> CENP-B_dimeris  Centromere protein B dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   1.2     0.074   2.7e+02      23      47 ..      23      47 ..      10      55 .. 0.74
   2 ?    6.8   0.0    0.0024       8.5      63      89 ..     370     396 ..     360     403 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.074
  CENP-B_dimeris 23 eeedeededeeddedddevpvpsfg 47
                    e+e++e + + dd d de+   s g
      EFC36312.1 23 EDEEDELDINLDDYDVDEICSSSQG 47
                    4455555667789999999888776 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0024
  CENP-B_dimeris  63 fpiddrvqshilhlehdlvhvtrknha 89 
                     +  +drv+   l leh +vh+t  + a
      EFC36312.1 370 IAKNDRVENFHLGLEHYVVHITTAEGA 396
                     5678*****************987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (827 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1085  (0.0605165); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.86u 0.35s 00:00:01.21 Elapsed: 00:00:00.56
# Mc/sec: 4437.07
//
Query:       EFC36313.1  [L=542]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.07   13.4   3.1         26    5.1   0.1    3.7  3  TPX2      Targeting protein for Xklp2 (TPX2)
      0.086   12.2   0.2       0.15   11.4   0.2    1.3  1  DUF4820   Domain of unknown function (DUF4820)
       0.23   11.9   1.6        1.2    9.7   0.3    2.8  3  AHSP      Alpha-haemoglobin stabilising protein
        3.8    7.4   6.8         15    5.4   0.7    2.5  2  YcaO_C    YcaO cyclodehydratase C-terminal domain


Domain annotation for each model (and alignments):
>> TPX2  Targeting protein for Xklp2 (TPX2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.2     0.006        27       6      19 ..      28      41 ..      26      45 .. 0.86
   2 ?    0.8   0.0      0.13     6e+02       9      23 ..     418     432 ..     414     444 .. 0.81
   3 ?    5.1   0.1    0.0059        26       2      17 ..     477     492 ..     476     494 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.006
        TPX2  6 RAekRkeFdkklee 19
                R  kRkeF++k  +
  EFC36313.1 28 RVSKRKEFEMKKSQ 41
                999*******9865 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.13
        TPX2   9 kRkeFdkkleekeka 23 
                 +Rk+F+ +l e  ++
  EFC36313.1 418 ERKQFYNALSELISK 432
                 9*******9997665 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0059
        TPX2   2 rsdeRAekRkeFdkkl 17 
                 +++eR ++R e+++ +
  EFC36313.1 477 NTEERKKERLEYEHNV 492
                 79***********987 PP

>> DUF4820  Domain of unknown function (DUF4820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2   3.5e-05      0.15      94     207 ..     376     490 ..     370     504 .. 0.57

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3.5e-05
     DUF4820  94 sdmvrfiQtrRrkLraikvrglkvkrlrkaeakseaeakkall.kkirltLstliCsrpgrsipvsseldnsartlterksekesaesseskkrnkeer 191
                    + + Q   + Lraik+ +++ k++   +a++++e++  +  k+    Ls li  ++ +  ++ss+    +++ ++ +++   +  ++ +++n   +
  EFC36313.1 376 LGPIDYFQVLAKDLRAIKTMAKRFKKVNLVHASMMKEMEAIIErKQFYNALSELIS-KTNTNTETSSNNHDFTEFENMTTTKDFFQFITNGNNQNGASE 473
                 5557788888999******************77776666554424577899**998.777666655333332222222222222233333333333333 PP

     DUF4820 192 daeseeessede.eeee 207
                 ++ ++ee +++  e e 
  EFC36313.1 474 TNINTEERKKERlEYEH 490
                 33344444333333333 PP

>> AHSP  Alpha-haemoglobin stabilising protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.12   5.5e+02      55      79 ..     197     220 ..     192     223 .. 0.81
   2 ?    9.7   0.3   0.00026       1.2      10      48 ..     204     244 ..     199     249 .. 0.82
   3 ?   -1.8   0.0      0.97   4.4e+03       8      27 ..     407     426 ..     403     438 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.12
        AHSP  55 eqqeqdralqelrqeLktlaspfLa 79 
                 e qe ++++++ +++L+   ++fL+
  EFC36313.1 197 ELQEDEKSMTKYQKNLRKC-KQFLT 220
                 67999*********99974.66765 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00026
        AHSP  10 glkefsvlLnq..qvfsdpliseedmvvvvdDWvnlYinyy 48 
                 ++ ++++ L +  q ++++  se+ ++++++DW ++Y +y 
  EFC36313.1 204 SMTKYQKNLRKckQFLTTESRSETSLKTILHDWYDIYEKYL 244
                 567777666655588899999****************9985 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.97
        AHSP   8 ssglkefsvlLnqqvfsdpl 27 
                 +s +ke+++++++++f ++l
  EFC36313.1 407 ASMMKEMEAIIERKQFYNAL 426
                 56799999999998886643 PP

>> YcaO_C  YcaO cyclodehydratase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.7    0.0034        15      92     120 ..     186     214 ..     173     218 .. 0.88
   2 ?    4.6   0.6    0.0061        28      62     142 ..     392     470 ..     381     485 .. 0.63

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0034
      YcaO_C  92 lfYraLkavLelaldeeleledyeenfer 120
                  + r+L++  +  +++e+ +++y++n+++
  EFC36313.1 186 FYVRCLDFYFDELQEDEKSMTKYQKNLRK 214
                 455***********************997 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0061
      YcaO_C  62 liaLalgdleeAlelvewtlqfndstaeralfYraLkavLelaldeeleledyeenfermyGeetveavlasvegevrfyg 142
                 + ++a +     l +++++ ++++   er++fY aL+ ++  +++ + e+++ +++f+     +t ++ ++ ++  ++ +g
  EFC36313.1 392 IKTMAKRFKKVNLVHASMMKEMEAI-IERKQFYNALSELIS-KTNTNTETSSNNHDFTEFENMTTTKDFFQFITNGNNQNG 470
                 5555544444445555555555555.9*********99876.566777777777777765555555555665555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (542 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1092  (0.0609069); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 3564.88
//
Query:       EFC36314.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       701  (0.0390987); expected 358.6 (0.02)
Passed bias filter:                      277  (0.0154498); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1002.21
//
Query:       EFC36315.1  [L=316]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-46  157.5  10.3    6.9e-46  157.0  10.3    1.2  1  G-alpha   G-protein alpha subunit


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  157.0  10.3   3.8e-50   6.9e-46     119     352 ..      66     315 ..       2     316 .] 0.84

  Alignments for each domain:
  == domain 1  score: 157.0 bits;  conditional E-value: 3.8e-50
                 ..................HHCCHHC-HCHHHHHHHHCCSHHHHHH.HCCGCCTT--TTHHHHHCT..HHHHCSTT----CHHHHCS-----SEEEEEEE CS
     G-alpha 119 e.................qeiefnpraevgedikaLwndpgiqel.yerrnkiklednaeyFldd..leritspdYlptddDilkarlktvGisetkfe 197
                 +                  e+++n+  e+++ i ++ +d+g+q+  +++r+ i ++++++yF d+   +r+ ++d++ + dD   a+ kt+Gis +k+ 
  EFC36315.1  66 NnylnrvkllsgqeyslfPESVWNN--ELAKLIFQMYQDEGFQNElFQNRQRIPFLESINYFTDKknSSRLLKNDFQLNFDDFFFASRKTTGISPFKY- 161
                 1223333334443344557788888..***************9874668899***********9556*******************************. PP

                 CT-TEEEEEEEE-SSHHHHHGTC...CCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS.-GG CS
     G-alpha 198 vdsklefrivdvgGqrserkkWv...pffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg.kls 292
                 v+ +++  i+d+gGqr+er kW+   + +++   i F++slsefd+++yed+ + r++e l+ F+e+  ++l+ +  ++L++ K+++leeK+kkg ++s
  EFC36315.1 162 VN-NHKKAIIDTGGQRTERSKWNrlhNTYSQKLHIGFVISLSEFDELCYEDDITPRFNEGLSNFEEWYGSPLVSEHTLYLIFSKFEVLEEKIKKGiSFS 259
                 55.89999***************5533469999****************************************************************** PP

                 GCCTT--H.CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHHHH CS
     G-alpha 293 kyfpsyegrkndlesvlkylrnkFeeihkeksnnrrkiythftsatdtkevqkviesvrd 352
                 +++++++g++ ++es ++++ +k++e+      +rr+++++++sa+ t++v ++++++ +
  EFC36315.1 260 RFVSEFKGDETSIESIVEFIVKKYLEL----DVKRRVVKYYVISAFKTEQVYQMLNEIFE 315
                 ***************************....3677899******************9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       690  (0.0384851); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1834.29
//
Query:       EFC36316.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 2073.11
//
Query:       EFC36317.1  [L=915]
Description: ATP dependent DNA ligase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.4e-50  170.2   2.9    7.8e-50  169.3   1.4    2.2  2  DNA_ligase_A_M   ATP dependent DNA ligase domain
    2.2e-27   95.2   0.9    5.7e-24   84.2   0.1    3.0  2  LIG3_BRCT        DNA ligase 3 BRCT domain
    1.1e-16   60.9   0.5      2e-07   31.3   0.0    2.9  2  BRCT_2           BRCT domain, a BRCA1 C-terminus domain
    5.8e-13   49.3   0.0    1.6e-12   47.9   0.0    1.8  1  DNA_ligase_A_C   ATP dependent DNA ligase C terminal region
    1.1e-10   41.7   2.3    1.9e-05   24.9   0.6    3.1  2  BRCT             BRCA1 C Terminus (BRCT) domain
    5.9e-09   36.4   0.6    1.9e-08   34.8   0.6    1.9  1  RNA_ligase       RNA ligase
    3.8e-06   26.7   0.1    2.5e-05   24.1   0.1    2.4  2  PTCB-BRCT        twin BRCT domain
     0.0031   17.4   2.8      0.021   14.7   2.8    2.3  1  mRNA_cap_enzyme  mRNA capping enzyme, catalytic domain
  ------ inclusion threshold ------
      0.029   14.5   1.0        0.3   11.2   0.3    2.8  3  BRCT_3           BRCA1 C Terminus (BRCT) domain
      0.055   13.6   0.1       0.58   10.3   0.1    2.3  2  TfoX_C           TfoX C-terminal domain
       0.11   12.6   1.1       0.34   11.0   1.1    1.9  1  Trans_coact      Phage late-transcription coactivator
       0.35   10.8   8.3        2.9    7.8   3.1    2.2  2  Velvet           Velvet factor
       0.87    8.5  20.2       0.35    9.8   2.2    2.4  2  DUF913           Domain of Unknown Function (DUF913)
          1    7.6  30.9       0.15   10.3  21.6    2.2  2  CDC45            CDC45-like protein
        2.7    7.7  21.4        4.4    7.1  14.9    2.3  2  RR_TM4-6         Ryanodine Receptor TM 4-6
        2.9    6.7  28.1       0.99    8.2  13.4    2.2  2  Apt1             Golgi-body localisation protein domain
        4.8    6.3  17.6        8.1    5.6   0.4    2.2  2  Zip              ZIP Zinc transporter


Domain annotation for each model (and alignments):
>> DNA_ligase_A_M  ATP dependent DNA ligase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.3   1.4   7.4e-53   7.8e-50       1     204 []       9     211 ..       9     211 .. 0.92
   2 ?   -1.2   0.0       1.3   1.3e+03      38      62 ..     320     344 ..     315     358 .. 0.84

  Alignments for each domain:
  == domain 1  score: 169.3 bits;  conditional E-value: 7.4e-53
                     -EEEEEESCHHHHHHHTTTSEEEEEEEESSEEEEEE..EETTEEEEEETTS-B-GG.GCHHHHHHHHHHBSTTESEEEEEEEEEEEETTTTCBEH CS
  DNA_ligase_A_M   1 pmLAeslksiekalkkleekafivEiKyDGeRaqvh..kegdkvklfSRrlkdita.akpelvkalkeafkkdeksvilDGElvavdketgeilp 92 
                     pmLA + k++ +++ ++  + f+ E+KyDGeR+q+h  +++d++k+fSR+lkd+ + + +++ k +++a+k++++svilDGE++++d++t++ilp
      EFC36317.1   9 PMLARPSKTYDDVIARC-PNGFYSELKYDGERIQIHydRKNDEIKYFSRNLKDVQEyKIKSVKKYISKAIKEKVESVILDGEILMMDTKTNKILP 102
                     9***************9.9*****************54499**************956677788899**************************** PP

                     HHHHCHHHHCHCCTHHHHHHSEEEEEEEEEEEETTEEHTTSCHHHHHHHHHHHB--BTTTEEE--EEEESSHHHHHHHH.....HHHHHTTECEE CS
  DNA_ligase_A_M  93 fqklasrkkkkkkveeklkeaelclfvFDiLyldgesltdeplkeRrklLeeilkesedrvelaeslevkdveeleell.....eeaiseglEGl 182
                     f++l +++++++k       a + +f+FDiLy++g+sl+  pl +R++l+++i++++++rv l e l+vk +++ +e++     + +i++g EGl
      EFC36317.1 103 FGTLGKNVRQDHK------DAVTTIFLFDILYYNGKSLLSVPLYKRKALMTKIVNPIKHRVMLGEYLVVKGSKQTREAIvsaemSAMIKKGEEGL 191
                     *******999994......55679*********************************************999988877522222678******** PP

                     EEEETT-CC-TTCEEEEEEEEE CS
  DNA_ligase_A_M 183 vvKnpdskYepgkrsknwlKvK 204
                     v+K+  s+Yep  r  +wlK+K
      EFC36317.1 192 VLKDLCSPYEPNAR--HWLKMK 211
                     **************..*****9 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.3
                     ETTEEEEEETTS-B-GGGCHHHHHH CS
  DNA_ligase_A_M  38 egdkvklfSRrlkditaakpelvka 62 
                     +g+++++ SR+ ++i+ ++p+++k 
      EFC36317.1 320 QGAEFSVSSRKDRPISVRFPRVTKI 344
                     6899***************999874 PP

>> LIG3_BRCT  DNA ligase 3 BRCT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0    0.0023       2.4       6      78 ..     711     785 ..     707     788 .. 0.78
   2 !   84.2   0.1   5.4e-27   5.7e-24       1      80 [.     824     905 ..     824     906 .. 0.97

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0023
   LIG3_BRCT   6 Ftgvklfipksv.edykklrRYfiAydGdlvkeeke..keaTHvvvskkeeskkekeksknakaVtaewiwesIkk 78 
                 F +v+ +i+    ++ + + ++++ ++G++ ++ +   ++ TH + +++  +  +   + +   Vt  w+ e+  k
  EFC36317.1 711 FRNVVALISGYSnSEKEAISKFITNNGGSVTNNWNIigNANTHLICESE-TEDFKHCFNLGSLIVTKYWVFECATK 785
                 77777777766545666899**********99988522679******66.5666667799999*********9766 PP

  == domain 2  score: 84.2 bits;  conditional E-value: 5.4e-27
   LIG3_BRCT   1 sLpdiFtgvklfipksvedykklrRYfiAydGdlvkeekekeaTHvvvskke...eskkekeksknakaVtaewiwesIkkrt 80 
                 sL+d+Ft+++++i+k+v++ k+++RY+iA+dG +v+++ ++++TH+++s+++   e++k +++++++++V++ewiw+sI+++t
  EFC36317.1 824 SLCDLFTDMVMYIHKDVPALKMHTRYIIAFDG-IVESSFSDDITHIITSSSRitpEIAKLVSENPQVNVVSSEWIWHSINTST 905
                 59******************************.****************9999999***********************9986 PP

>> BRCT_2  BRCT domain, a BRCA1 C-terminus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.1   4.1e-09   4.3e-06      14      84 ..     719     794 ..     706     795 .. 0.85
   2 !   31.3   0.0   1.9e-10     2e-07       3      84 ..     827     912 ..     825     913 .. 0.93

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 4.1e-09
      BRCT_2  14 daepspsreklkklIeknGGevveti...tsavyiviaesneee..laekrkrrvvspkyIkdCikkgkllpleny 84 
                 + + ++++e + k I++nGG v+++     +a++++i+es++e+  +  + +  +v+  ++++C  kg l++  +y
  EFC36317.1 719 SGYSNSEKEAISKFITNNGGSVTNNWniiGNANTHLICESETEDfkHCFNLGSLIVTKYWVFECATKGYLVDTLPY 794
                 4455689***************99997776789*******99999999999*********************9888 PP

  == domain 2  score: 31.3 bits;  conditional E-value: 1.9e-10
      BRCT_2   3 klFeglrFYindaepspsreklkklIeknGGevvetitsavyiviaesneee......laekrkrrvvspkyIkdCikkgkllpleny 84 
                 +lF+++  Yi   ++ p  +  ++ I++++G v+++ +++ +++i++s+  +       +e+++ +vvs ++I ++i+  +l++ + y
  EFC36317.1 827 DLFTDMVMYI--HKDVPALKMHTRYIIAFDGIVESSFSDDITHIITSSSRITpeiaklVSENPQVNVVSSEWIWHSINTSTLIDWRLY 912
                 69********..45559***********************999999999999*******************************98877 PP

>> DNA_ligase_A_C  ATP dependent DNA ligase C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.9   0.0   1.5e-15   1.6e-12       2      99 .]     237     348 ..     236     348 .. 0.75

  Alignments for each domain:
  == domain 1  score: 47.9 bits;  conditional E-value: 1.5e-15
                     GGSEEEEEEEEEE..TTEEEEEEEE-SS--HHHHHHHHHHHG...GGEECTTCE...SS---HHHHTT..EE.E-.TT-EE..EEEESEEECTSS CS
  DNA_ligase_A_C   2 gglvgslllgvyd..dgkleyvgkvgtGfsdaeleelrkklk...elerkkppf...aekvpeeekrd..vW.ve.Pelvv..eVkfaeitasgk 82 
                     ggl++ +++g  d   gk++ ++k+g+G +d+++e+l+++lk   +   k+p++       + ++++    + v+ P+++v  e+++ae++ s +
      EFC36317.1 237 GGLMSVFMMGSFDkkLGKWRIICKCGNGHDDQTIETLNEELKsnmKRISKDPSLvpdD--IDIHTNALvpDFiVKdPKKSVvwEIQGAEFSVSSR 329
                     78999********98999***********************98873333444443431..22222222344443346544355**********97 PP

                     STT..EECT-EEEEE-TTS CS
  DNA_ligase_A_C  83 yka..slRfPrfkrlReDk 99 
                      +   s+RfPr++++R+Dk
      EFC36317.1 330 KDRpiSVRFPRVTKIRDDK 348
                     7779**************8 PP

>> BRCT  BRCA1 C Terminus (BRCT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.6   1.8e-08   1.9e-05       2      78 ..     707     782 ..     706     783 .. 0.87
   2 !   15.2   0.0   1.9e-05      0.02       4      79 .]     827     901 ..     824     901 .. 0.84

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 1.8e-08
                 TTTTTTTEEEEEEESTSSHHHHHHHHHHHHTTCEEESSC...STTSSEEEESSSHSHHHHHHHHHHTTSEEEETHHHHHH CS
        BRCT   2 kellfhgckfvitgvldnftrdeleelikehGGkvttev...skktthlvvgepesrslkylealklnipivheewlldc 78 
                 + ++f++++  i ++++n +++ + ++i ++GG+vt+ +    + +thl++ +    ++ +++  +l+  iv+  w+++c
  EFC36317.1 707 NNTFFRNVVALI-SGYSNSEKEAISKFITNNGGSVTNNWniiGNANTHLICESE---TEDFKHCFNLGSLIVTKYWVFEC 782
                 6789********.**********************9888334589*****8666...77888889999999999999999 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 1.9e-05
                 TTTTTEEEEEEESTSSHHHHHH.HHHHHHTTCEEESSCSTTSSEEEESSS.HSHHHHHHHHHHTTSEEEETHHHHHHH CS
        BRCT   4 llfhgckfvitgvldnftrdel.eelikehGGkvttevskktthlvvgep.esrslkylealklnipivheewlldci 79 
                 +lf++++++i  ++d    + +  + i  + G v +++s+++th++++++ ++    +l + + ++ +v+ ew++++i
  EFC36317.1 827 DLFTDMVMYI--HKDVPALK-MhTRYIIAFDGIVESSFSDDITHIITSSSrITPEIAKLVSENPQVNVVSSEWIWHSI 901
                 6899999999..55554444.4599*************************7555566999999************987 PP

>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.8   0.6   1.8e-11   1.9e-08       6     161 .]      32     211 ..      28     211 .. 0.66

  Alignments for each domain:
  == domain 1  score: 34.8 bits;  conditional E-value: 1.8e-11
                 EEE-SSEEEEEEEETT...EEEEETTCEBCTTTHHHHHHTHHHHHHHHHHHHH....ECCEEEEEEEES......SS........TTSS.......... CS
  RNA_ligase   6 tEKlDGtnfriylvke...vgvasRsqilpfgeekfkefkrwaaalrkklkekla..neelilyGElig.....hsi......kygglpk......... 79 
                 + K DG++++i+++++   ++++sR+    ++e       ++ +  +k++ + ++  +e++il GE++      ++i            k         
  EFC36317.1  32 ELKYDGERIQIHYDRKndeIKYFSRNLKD-VQE-------YKIKSVKKYISKAIKekVESVILDGEILMmdtktNKIlpfgtlG-----Knvrqdhkda 117
                 67************55578*******888.333.......44444555555555566778*********877765557555441.....1334444788 PP

                 ..EEEEEEEEEEECTTBECE--HHHHHHHHHCCT....B..EEEEE.SS.HHHHHCCC.........HHHHTC--EEEEEESSSSBE.TTEBSEEEEE CS
  RNA_ligase  80 ..efyvFdifdirdkeeqrylspdevealakglg....tvpvlyegkfl.aaeellel........llskgnkrEGlVikpeselyk.nkgraifKvk 161
                    +++Fdi+  ++ ++   ++  +++al +++     +  +l+e+ +  ++++ +e         +   ++  EGlV+k+  + y+ n  r+++K+k
  EFC36317.1 118 vtTIFLFDILYYNG-KSLLSVPLYKRKALMTKIVnpikHRVMLGEYLVVkGSKQTREAivsaemsaM--IKKGEEGLVLKDLCSPYEpNA-RHWLKMK 211
                 99********9873.3555556666655555443455444445444444444444444777765442..34589*******999999775.*****97 PP

>> PTCB-BRCT  twin BRCT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.1   2.4e-08   2.5e-05       2      45 ..     715     760 ..     714     778 .. 0.81
   2 ?   -0.9   0.0       1.5   1.6e+03      27      43 ..     857     873 ..     847     896 .. 0.69

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 2.4e-08
                 EEEEECB-TTCHHHHHHHHHHTT-EEESSEE...TT-SEEEECSS-C CS
   PTCB-BRCT   2 vicvtgysgddrkslqklieamGaeyskdlt...ksvTHLicksgeG 45 
                 v+ ++gys+++++ + k i+ +G++++ +++   + +THLic+s   
  EFC36317.1 715 VALISGYSNSEKEAISKFITNNGGSVTNNWNiigNANTHLICESE-T 760
                 7889**************************755589******864.3 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.5
                 EESSEETT-SEEEECSS CS
   PTCB-BRCT  27 yskdltksvTHLicksg 43 
                 +   ++ ++TH i  s+
  EFC36317.1 857 VESSFSDDITHIITSSS 873
                 55567788999998654 PP

>> mRNA_cap_enzyme  mRNA capping enzyme, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   2.8     2e-05     0.021      20     130 ..      31     158 ..      26     211 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2e-05
                      EEEEESSEEEEEEEEECTEEEEEEETTS-EEEESSST-BTTSSSSTCTSBGGSEEEEEEEE.EEECTT................CEEEEEEEEE CS
  mRNA_cap_enzyme  20 vseKaDGiRylmllteeeegvylidRenevyrvenlrfprekdkeklekvldetllDgElv.idkvee................kkkelryliy 96 
                         K DG R+ +  +++++++  + R+ +  +  +++ + ++ ++  ++  ++ +lDgE+  +d+  +                k ++    ++
       EFC36317.1  31 SELKYDGERIQIHYDRKNDEIKYFSRNLKDVQEYKIKSVKKYISKAIKEKVESVILDGEILmMDTKTNkilpfgtlgknvrqdhKDAVTTIFLF 124
                      55699*************99******987666666666667655568899999******751565444567777776666544334456789** PP

                      EEEEETTEEGTTSBHHHHHHHHHHHTHHHHHHHH CS
  mRNA_cap_enzyme  97 DivaingvtvaeeplskRleilkkelikprneek 130
                      Di+  ng+++ + pl+kR +++ k +  ++++ +
       EFC36317.1 125 DILYYNGKSLLSVPLYKRKALMTKIVNPIKHRVM 158
                      ******************9988887766665554 PP

>> BRCT_3  BRCA1 C Terminus (BRCT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       7.9   8.4e+03      19      46 ..     253     280 ..     241     301 .. 0.69
   2 ?   -0.1   0.0      0.93   9.8e+02      57      87 ..     759     788 ..     709     792 .. 0.64
   3 ?   11.2   0.3   0.00028       0.3      46      86 ..     863     905 ..     838     911 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 7.9
      BRCT_3  19 elWseilklaGaavvkkekseaeeislg 46 
                   W+ i+k++ ++  +++++ +ee++ +
  EFC36317.1 253 GKWRIICKCGNGHDDQTIETLNEELKSN 280
                 5699999999998877777766664444 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.93
      BRCT_3  57 cpeevlkkaeqlkipvvSteWviQsLIegev 87 
                  +e+ +++ + l+  +v++ Wv ++  +g +
  EFC36317.1 759 ETEDFKHCFN-LGSLIVTKYWVFECATKGYL 788
                 4555555544.56679999999999777765 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00028
      BRCT_3  46 gkldvvvtdss.cpeevlk.kaeqlkipvvSteWviQsLIege 86 
                 + ++ ++t ss ++ e+ k ++e+ +++vvS+eW+  s+ +++
  EFC36317.1 863 DDITHIITSSSrITPEIAKlVSENPQVNVVSSEWIWHSINTST 905
                 5567788888877777766156778**********99986665 PP

>> TfoX_C  TfoX C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.1   0.00055      0.58      53      79 ..     603     629 ..     585     630 .. 0.85
   2 ?    0.1   0.0      0.81   8.6e+02      52      70 ..     775     793 ..     761     805 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00055
      TfoX_C  53 lLyaLegAlqgvhwndlpeeekeeLle 79 
                  Ly L+ A++g  wn +++  ke+L +
  EFC36317.1 603 HLYRLHHAISGLDWNRVEQLLKENLSN 629
                 49*********************9986 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.81
      TfoX_C  52 elLyaLegAlqgvhwndlp 70 
                   ++++e+A +g  ++ lp
  EFC36317.1 775 TKYWVFECATKGYLVDTLP 793
                 449********99888877 PP

>> Trans_coact  Phage late-transcription coactivator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   1.1   0.00032      0.34      30      51 ..      62      83 ..      58     100 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00032
  Trans_coact 30 ndieeeqvpklIskpLkeKika 51
                 +++ +++v+k+Isk++keK ++
   EFC36317.1 62 QEYKIKSVKKYISKAIKEKVES 83
                 678899*************975 PP

>> Velvet  Velvet factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   3.1    0.0027       2.9      49     173 ..     351     497 ..     325     499 .. 0.56
   2 ?    5.8   0.2     0.011        12      49     125 ..     627     715 ..     600     808 .. 0.60

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0027
                 ---TTEEEEEEEEETTSSSB--EE.....................--.---------.....------------------------------------- CS
      Velvet  49 ldssffvvtvdLwsedgtkevnlv.....................kssssasssiss....easssssqsseesssspksqassaessapsssaapsaq 122
                 ld++++   ++L +e+ +k +  v                     k++s+a++s  s    ++s sss+++++s+ ++  +++ +++ + ++sa++ + 
  EFC36317.1 351 LDHTNYQEIIKLKNESNRKGL--VpifgdgdagddsdesvdvkdkKKRSRAKKSK-SddedDESDSSSKKKKNSRKKKINSSDDEDDEDDKKSAKKPND 446
                 667777777777775544443..33467777777777666666642222222222.2345333333333333333333333333333333333344444 PP

                 ---------------------EESEEE--EEE-EEEE-TT--EEEEEE--- CS
      Velvet 123 eekekkeatlssssnqasskltrnLiGslvasafrlkdpedkpgifFvfqD 173
                 ++k+k++ +++ + +++++k  ++ iG + + +   ++ ++ + i+++  D
  EFC36317.1 447 KKKSKSSDNSDDDDDPKAKKAKKSTIGIKLSDIDTINNSSTPEQIYYIYGD 497
                 445555555555666668999999999999998888887777888877655 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.011
                 ---TTEEEEEEEEETTSSSB--EE--.---------..---------------------------------------.............- CS
      Velvet  49 ldssffvvtvdLwsedgtkevnlvkssssasssiss.easssssqsseesssspksqassaessapsssaapsaqee.............k 125
                 l+++ f v+++  + d +  vn  k++ +++  + + +a+s ss++  +  s+++ +++s++++++sss+++ + ee              
  EFC36317.1 627 LSNKGFAVFIYTKDRDDKDRVNESKNKLANRPTTDNsAAASDSSHKMDT--SDDNAPTTSTNKMTKSSSQTSIKVEEqdsssnntffrnvV 715
                 6677777777777766555555543322222222221111111111111..2222222333333333222222221112222223444440 PP

>> DUF913  Domain of Unknown Function (DUF913)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7  10.3     0.024        25     268     317 ..     402     456 ..     348     484 .. 0.53
   2 ?    9.8   2.2   0.00033      0.35     267     352 ..     647     737 ..     604     741 .. 0.59

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.024
      DUF913 268 asskseasssssssetkeeek.........ssededvemeda......eeetesesdeseeseee 317
                 ++s++e ++s+sss++    k         ss+ded+e++++      +      +++s++s+++
  EFC36317.1 402 SKSDDEDDESDSSSKK----KknsrkkkinSSDDEDDEDDKKsakkpnD------KKKSKSSDNS 456
                 1111111111111111....12234556776666665555553333321......2222222222 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00033
      DUF913 267 sasskseasssssssetkeeekssededvemeda....eeetesesdeseeseeekeknslldyilnvakFLeallsnns.lcreFvekgG 352
                 +++sk++ ++ ++++++ + + ss ++d+ +++a    +++++++s++++ + ee++++s   ++ nv+ +++++ + ++   ++F+ ++G
  EFC36317.1 647 VNESKNKLANRPTTDNSAAASDSSHKMDTSDDNApttsTNKMTKSSSQTSIKVEEQDSSSNNTFFRNVVALISGYSNSEKeAISKFITNNG 737
                 233333333222222222222233333333333354434555555555555666677777999************97666477****8877 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3  21.6   0.00015      0.15      97     195 ..     365     470 ..     349     517 .. 0.47
   2 ?    2.6   1.8     0.032        34     143     207 ..     642     702 ..     613     760 .. 0.48

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00015
       CDC45  97 sseekerivvfDDgdieeeleeere....ayealeeeeesdeedeeeeeeddd..deeeee.eeeedeedeeedeeeskkkrksksdeeeesdddders 188
                 +s++k+ + +f Dgd  ++ +e+ +    +  +  ++++sd+ed+e+++++++  ++++++ ++++de+de+++++ +k ++k+ks+++++sdddd+++
  EFC36317.1 365 ESNRKGLVPIFGDGDAGDDSDESVDvkdkKKRSRAKKSKSDDEDDESDSSSKKkkNSRKKKiNSSDDEDDEDDKKSAKKPNDKKKSKSSDNSDDDDDPK 463
                 346778888998888755555433311011111122222222222222222221122222202222222222333333333335555555577777777 PP

       CDC45 189 rkrrrse 195
                 +k+ +++
  EFC36317.1 464 AKKAKKS 470
                 7777766 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.032
       CDC45 143 ddddeeeeeeeeedeedeeedeeeskkkrksksdeeeesddddersrkrrrsepsakklrrqlkk 207
                 dd+d  +e++++ +++ + +d++ + +++++k d++++  ++ + s ++  ++ s++++ + +++
  EFC36317.1 642 DDKDRVNESKNKLANRPT-TDNSAAASDSSHKMDTSDD--NAPTTSTNKMTKS-SSQTSIKVEEQ 702
                 222222222211111111.1111111111111111111..1111111111111.11111111111 PP

>> RR_TM4-6  Ryanodine Receptor TM 4-6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  14.9    0.0041       4.4      50     154 ..     360     459 ..     311     478 .. 0.49
   2 ?    4.2   0.4      0.03        32      95     177 ..     647     709 ..     601     723 .. 0.48

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0041
                 XXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX..........XXXXXXXXXXX CS
    RR_TM4-6  50 ldlkkeggqykvvakkseagLgDlseteaeesptpelkkklaeeeeaeeekeeeeepeaeaeekadaengekeekekekeeeekeseeeeeekkkkkka 148
                 ++lk+e++ + +v+   +   gD ++++ e+    ++ kk+ ++ +++++++e++e+ +++++k+++++++ ++++ e +e++k+s+++ + kkk k +
  EFC36317.1 360 IKLKNESNRKGLVPIFGD---GDAGDDSDESVD--VKDKKKRSRAKKSKSDDEDDESDSSSKKKKNSRKKKINSSDDEDDEDDKKSAKKPNDKKKSKSS 453
                 445666665555555544...333333333332..2233333334444444444444444444444444444444444333333333333333333322 PP

                 XXXXXX CS
    RR_TM4-6 149 kskkke 154
                  ++  +
  EFC36317.1 454 DNSDDD 459
                 222222 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.03
                 XXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX..........XXXXXXXXXXXXXXXXXXXXXXXXX-HHHHHHHHHHHHHH CS
    RR_TM4-6  95 eaeeekeeeeepeaeaeekadaengekeekekekeeeekeseeeeeekkkkkkakskkkeeaeaeesellkklevyqtkllny 177
                 ++e++++ ++ p+                    +++++ +s  ++++     +a +++ ++ ++++s++  k+e +  +  n 
  EFC36317.1 647 VNESKNKLANRPT--------------------TDNSAAASDSSHKMDTSDDNAPTTSTNKMTKSSSQTSIKVEEQDSSSNNT 709
                 2222222222222....................22222222222222222222222333333333333333333333333333 PP

>> Apt1  Golgi-body localisation protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2  13.4   0.00094      0.99     321     386 ..     388     463 ..     346     544 .. 0.53
   2 ?    4.1   6.7     0.016        17     315     386 ..     639     708 ..     617     765 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00094
        Apt1 321 deesessssss..ssssssassssssssrssslelrlk.pt.......sstssssssessssssskkrsseessle 386
                  + ++++++s   +s+s++++++s+sss+++++++++k ++       + ++s+++++ +++s s+++s +++  +
  EFC36317.1 388 VDVKDKKKRSRakKSKSDDEDDESDSSSKKKKNSRKKKiNSsddeddeDDKKSAKKPNDKKKSKSSDNSDDDDDPK 463
                 2222222221122222222222222222222222221211122222221111111111111111111111111111 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.016
        Apt1 315 eeddesdeesessssssssssssassssssssrssslelrlkptsstssssssessssssskkrsseessle 386
                 +++d++d+ +es+++  ++ ++++s+++s+ss +   ++ + pt+st++ ++s+  s++s k +++++ss +
  EFC36317.1 639 KDRDDKDRVNESKNKLANRPTTDNSAAASDSSHKMDTSDDNAPTTSTNKMTKSS--SQTSIKVEEQDSSSNN 708
                 333333333444334335555555555555555555555544443333332222..2222222222322222 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4  11.3     0.017        18     103     187 ..     391     472 ..     371     482 .. 0.68
   2 ?    5.6   0.4    0.0077       8.1     102     166 ..     639     707 ..     611     805 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.017
         Zip 103 ksshkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqaseeedkeklaslkvrai 187
                 k+++k+   kk++s+++  ++ +s +++k + +++ ++ + e+d+d+++++++ n+k+++++s+ +    ++d++k+++ k  +i
  EFC36317.1 391 KDKKKRSRAKKSKSDDEDDESDSSSKKKKNSRKKKINSSDDEDDEDDKKSAKKPNDKKKSKSSDNSD---DDDDPKAKKAKKSTI 472
                 4556666666677777777777777777777777777878888888887777777777766666665...445555555544444 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0077
         Zip 102 k....ksshkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksese 166
                 k    k++ +e  +k a+ +++ ++a+ s s++k+++s ++    +  +++++s+++  + +++ s+s+
  EFC36317.1 639 KdrddKDRVNESKNKLANRPTTDNSAAASDSSHKMDTSDDNAPTTSTNKMTKSSSQTSIKVEEQDSSSN 707
                 234556677778888888888888888888888888888887766666666665555444444433333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (915 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2169  (0.120977); expected 358.6 (0.02)
Passed bias filter:                      651  (0.0363099); expected 358.6 (0.02)
Passed Vit filter:                       179  (0.00998383); expected 17.9 (0.001)
Passed Fwd filter:                        79  (0.00440627); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 1.35u 0.36s 00:00:01.71 Elapsed: 00:00:00.55
# Mc/sec: 5013.66
//
Query:       EFC36318.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       467  (0.0260472); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 835.09
//
Query:       EFC36319.1  [L=125]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.7e-06   26.6  83.4          5    7.1  49.2    2.5  2  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1  49.2   0.00028         5      60     109 ..       8      57 ..       1      69 [. 0.33
   2 !    5.3  50.3     0.001        19      59     103 ..      57     101 ..      41     119 .. 0.37

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00028
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepep 109
                  +pep+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p
   EFC36319.1   8 KPEPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 57 
                  22222222222222222222222222222222222222222222222222 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.001
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepep 103
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p
   EFC36319.1  57 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 101
                  122222222222222222222222222222222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (125 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       238  (0.0132746); expected 358.6 (0.02)
Passed bias filter:                       86  (0.0047967); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 718.18
//
Query:       EFC36320.1  [L=450]
Description: ERG4/ERG24 ergosterol biosynthesis family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.2e-69  233.1  21.8    6.3e-69  232.8  21.8    1.0  1  ERG4_ERG24  Ergosterol biosynthesis ERG4/ERG24 family


Domain annotation for each model (and alignments):
>> ERG4_ERG24  Ergosterol biosynthesis ERG4/ERG24 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  232.8  21.8   3.5e-73   6.3e-69      19     432 .]      34     450 .]      25     450 .] 0.89

  Alignments for each domain:
  == domain 1  score: 232.8 bits;  conditional E-value: 3.5e-73
  ERG4_ERG24  19 glpvlelylnaiskfealklllpksldlaelkneikeldllvfegaiwerklftvfllfyvlqavlylllpGkvveGleLsngkkLkYkinalaslllv 117
                 + p+  ly  ++ +   + ++l++ +  + + n i ++ + +  g   ++ ++++ ++f +lq+ l  +lpGk+ +G    +g+   Y+ n+l + l++
  EFC36320.1  34 TPPCAFLYWYTCEHLGGSVIALFNMFGKEGIINSIVSIVQPYILG---SKVAWAIIVVFSILQLTLMKVLPGKKFNGPMTPKGNLPVYTDNGLLAYLIT 129
                 556777777777777888888888888888888888877766666...99***************************8888999889********8888 PP

  ERG4_ERG24 118 laillv..lqvtelfeltvlidnfvqlisvailfafalaivlYvrslkvkerkkdkqlaaggvsGnliYDffiGreLnPRlgslDlkmFlelRlgllll 214
                 + +      +  +lf   +l+++f  li +  +f++++ ++l ++ + +++     + + g + Gn i D++ G eL P +  +D+k+F++ R g++ +
  EFC36320.1 130 IMLFFLcsSTGLNLFPSSILYNHFPYLIGALNIFSLVFCLFLQIKGMYFPS-----STDCGSNEGNFIMDYYWGTELHPVVFGFDVKVFTNCRFGMMSW 223
                 87765511566799**********************************999.....4579*************************************** PP

  ERG4_ERG24 215 llinlaallkqyklygkvtdslllvllaqllYvfdgvkneeavlttmDittdgFGFmLaFgdlvlvPftYslqtlYLsvhPselgwstvlvailvvlli 313
                  l+ l++++kqy+++g+ +ds+++ l++q +Y+    + e + l  +Di +d+ G+ + +g lv+vP +Y+  +lY+s  P +lg    ++ il+  + 
  EFC36320.1 224 PLLILSFAAKQYEVTGQLSDSMIINLVIQFIYLTKFYMWESGYLCSIDIMHDRAGYYICWGCLVWVPSVYTSTSLYISKYPNNLGPY-WTAFILIGGAS 321
                 ************************************************************************************977.45566666666 PP

  ERG4_ERG24 314 gyyiFrsansqknnFR.......tnPedpklkllkyiqtktGsk....LlvsGWyglarkinYlgDwlqslswsLatgfqsvlpyfyvlyFlvlLvhRe 401
                 +  +  +a+ q++n R          ++p l+  ++i  ++G k    Ll+ G++g++r+ +Y+ ++l ++ w++++ f++ lpyfy  +  +lL hR+
  EFC36320.1 322 AVILNYLADIQRQNVRkangkclVWGKKPALIEGEIIA-ENGDKkkfiLLICGFWGITRHFHYVMELLGTFFWTVPALFNNFLPYFYLFFLTILLFHRA 419
                 66667789999999998888888777888888777665.4454334559************************************************** PP

  ERG4_ERG24 402 lRDeekCkkkYGedweeYkkkvpykiipyvy 432
                  RD+++C+kkYG+ weeY+++vpyk+ipyv+
  EFC36320.1 420 ERDQKRCSKKYGKYWEEYCRRVPYKVIPYVF 450
                 ******************************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (450 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2751.19
//
Query:       EFC36321.1  [L=686]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.1e-06   26.8  14.7      7e-06   26.1  14.7    1.3  1  Zn_clus       Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1  14.7   3.9e-10     7e-06       2      39 ..      66     102 ..      65     103 .. 0.93

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 3.9e-10
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 +C nCrk ++ C++++P+Cs C ++n eC  y+ ++k+
  EFC36321.1  66 SCLNCRKSHRSCNKQFPTCSDCFERNQECI-YECPKKK 102
                 8*****************************.9887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (686 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2141  (0.119415); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.94u 0.32s 00:00:01.26 Elapsed: 00:00:00.52
# Mc/sec: 3956.22
//
Query:       EFC36322.1  [L=100]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        0.4   10.8   5.0        3.9    7.7   0.9    2.2  2  Herpes_UL49_2  Herpesvirus UL49 tegument protein


Domain annotation for each model (and alignments):
>> Herpes_UL49_2  Herpesvirus UL49 tegument protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.9   0.00021       3.9      18      58 ..      28      68 ..      15      75 .. 0.79
   2 ?    5.9   0.5   0.00074        13      42      63 ..      71      92 ..      58      95 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00021
                   --S-SSSTTS---HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Herpes_UL49_2 18 fstaPasasssWrsttaafnkrvFceavsrvaaaqaekaae 58
                   + +a ++a+ +W +tt a+n  ++ +a         ++a  
     EFC36322.1 28 YNAAFNAATTPWMATTGAYNPALYSNAYMGANSFTPYLATS 68
                   56788999**************9999976666555555555 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.00074
                   HHHHHHHHHHHHHHHHHHHHHH CS
  Herpes_UL49_2 42 ceavsrvaaaqaekaaealWek 63
                      +  +a +qa  aa + W +
     EFC36322.1 71 TSTIPILANMQASSAAFNTWST 92
                   5567789*************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (100 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.27s 00:00:00.69 Elapsed: 00:00:00.44
# Mc/sec: 682.41
//
Query:       EFC36323.1  [L=131]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       241  (0.0134419); expected 358.6 (0.02)
Passed bias filter:                      225  (0.0125495); expected 358.6 (0.02)
Passed Vit filter:                         4  (0.000223102); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.42
# Mc/sec: 937.70
//
Query:       EFC36324.1  [L=149]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.084   12.8   0.0       0.13   12.2   0.0    1.4  1  DUF4743   Domain of unknown function (DUF4743)


Domain annotation for each model (and alignments):
>> DUF4743  Domain of unknown function (DUF4743)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   7.4e-06      0.13      27      70 ..      19      62 ..       4      82 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 7.4e-06
                EEEEEEEHHHHHHHCT-TTTEEE-SS.EEEE-TT--SHHHHHHH CS
     DUF4743 27 qqvGlirpdvaeklrkfpdvFevsekeaveLapslktyeeRtaa 70
                +  G+++++ + +l+k+++vF++++   +++ p+ k+ ++Rt++
  EFC36324.1 19 HMFGILKSQKTIQLSKHESVFCLTSGIDLQFTPTKKQTKKRTNK 62
                7889**********************99999**********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1603  (0.0894082); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 953.69
//
Query:       EFC36325.1  [L=257]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-10   40.4   1.5    2.8e-10   39.9   0.8    1.5  1  PIP5K     Phosphatidylinositol-4-phosphate 5-Kinase
  ------ inclusion threshold ------
       0.08   12.8   0.5       0.08   12.8   0.5    2.4  3  Lamp      Lysosome-associated membrane glycoprotein (Lamp)


Domain annotation for each model (and alignments):
>> PIP5K  Phosphatidylinositol-4-phosphate 5-Kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.9   0.8   3.1e-14   2.8e-10      20      89 ..     111     180 ..     102     189 .. 0.92

  Alignments for each domain:
  == domain 1  score: 39.9 bits;  conditional E-value: 3.1e-14
                 EETTSSEEEEEE-HHHHHHHHH.HHHHHHHHHTT-TT--S--EEEEEEEE.ETTEEEEEEEEE-SS-TTS- CS
       PIP5K  20 lteDkkfiiKtitksevkflrk.llpeYyehvkenpnsLltrfyglhrvklkggkkvrfvVmenlfptdke 89 
                 +t+D+kf iK++tk e+k +r+ ++p+ ++ +k+ +n  ++ ++gl+++ + ++k++rfvV  n f+++++
  EFC36325.1 111 MTKDSKFFIKSVTKMEAKEIRStIIPSLIKEMKKSRNITIAPIMGLFKI-IVNKKTIRFVVTLNFFKPAED 180
                 79***********************************************.559*************97764 PP

>> Lamp  Lysosome-associated membrane glycoprotein (Lamp)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0     0.074   6.7e+02      29      56 ..      12      39 ..       7      49 .. 0.77
   2 ?   12.8   0.5     9e-06      0.08      52      93 ..      76     117 ..      53     135 .. 0.86
   3 ?   -2.5   0.2      0.47   4.2e+03      99     119 ..     191     211 ..     184     240 .. 0.57

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.074
                ECTTTTCCEEEEE--CCCEEEEEE--SS CS
        Lamp 29 kkksnktvsrvfnlnPnktkasGsCekq 56
                k++++ +++  ++++ + t++s +Ce+ 
  EFC36325.1 12 KRSQDVETRLKLIIKHSMTQVSNNCEEY 39
                555556666688999999*******984 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 9e-06
                 E--SSEEEEEEEETTEEEEEEEEE-TTTSEEEEEEEEEEEEE CS
        Lamp  52 sCekqsaeLkLnsesgtltftFaknasenkfylsevnvsltl 93 
                  C+ +++e+ ++ +++t +f+F+k+ +++k ++++++   ++
  EFC36325.1  76 MCGMTEREFFMSIQESTFSFEFHKDLENKKCFVQSMTKDSKF 117
                 6**********************************9877666 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.47
                 EEEEEEE-S--EEEEETTSEE CS
        Lamp  99 ktfsaensslseleaslgsSy 119
                 k++s +n+sl+  +     S 
  EFC36325.1 191 KSISYSNDSLNSYKQHQQYSL 211
                 555555555555444433333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1309  (0.0730102); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1560.19
//
Query:       EFC36326.1  [L=167]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       939  (0.0523733); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1031.14
//
Query:       EFC36327.1  [L=711]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (711 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1040  (0.0580066); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 4329.61
//
Query:       EFC36328.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.079   13.2   0.0       0.15   12.3   0.0    1.5  1  Chromo_2  Chromatin organization modifier domain 2
        1.1    8.8  12.6       0.31   10.6   9.5    1.5  2  Miff      Mitochondrial and peroxisomal fission factor Mff


Domain annotation for each model (and alignments):
>> Chromo_2  Chromatin organization modifier domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   1.7e-05      0.15       6      31 ..      60      89 ..      58     124 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.7e-05
    Chromo_2  6 vKkRvvngvasyEveWkkpesvveg....s 31
                +K+R   + asyE +W+++++++++    +
  EFC36328.1 60 KKTRSMCSLASYESVWNMNNTMIQNsmpqQ 89
                79******************9996555540 PP

>> Miff  Mitochondrial and peroxisomal fission factor Mff
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1      0.15   1.4e+03     152     190 ..      12      50 ..       2      80 .. 0.50
   2 ?   10.6   9.5   3.4e-05      0.31      74     163 ..      79     182 ..      70     202 .. 0.61

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.15
        Miff 152 vtpsaeqvrvcppllspedganlysargilsliqsttrr 190
                 +++s+ + r+ +     +++ +l+s ++i s+  ++ + 
  EFC36328.1  12 SSKSKTRGRIQKKAPRRQKTFSLFSNHNIQSTSFKVLQS 50 
                 334444444444444444455555555555444433333 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 3.4e-05
        Miff  74 dldliqsiplesllslktpprvltLserpldfldlekaasasdeneevrssgrlrrersasenaavrqngqlvrndsi....................v 152
                 ++++++s+p++ +++ + pp ++tL+  p      ++++++s+ n    +++r +r  s s+   +   ++ +++++i                    +
  EFC36328.1  79 NTMIQNSMPQQPCVHSNCPPIIVTLTSSPS----NNHTQQQSPTNTTPCTASRKKRVMSSSSL--SSMCDSSSSENTIiaapiniipsmqgchpilphS 171
                 67999*************************....44466666666664444444444444444..2333333333433456555444444444444433 PP

        Miff 153 tpsaeqvrvcp 163
                 ++s++qv++++
  EFC36328.1 172 QSSPQQVNISS 182
                 33444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       918  (0.051202); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1394.77
//
Query:       EFC36329.1  [L=649]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-95  311.0  29.9      3e-13   49.3   0.1   11.7 11  DUF4116   Domain of unknown function (DUF4116)
    0.00067   19.4   0.7        3.4    7.5   0.0    4.5  4  DBD_HTH   Putative DNA-binding domain
    0.00095   19.7   3.7        1.6    9.3   0.0    5.2  6  CbiG_C    Cobalamin synthesis G C-terminus
  ------ inclusion threshold ------
        1.3    8.6  15.2        3.6    7.2   0.1    4.9  5  ArsR      ArsR transcriptional regulator


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   0.0   3.8e-10   1.7e-06       1      48 [.      83     129 ..      83     130 .. 0.95
   2 !   47.3   0.5   2.8e-16   1.3e-12       1      48 [.     132     179 ..     132     192 .. 0.95
   3 !   35.4   0.1   1.4e-12   6.3e-09       1      49 []     213     261 ..     213     261 .. 0.97
   4 !   28.5   0.1   2.1e-10   9.4e-07       4      42 ..     266     304 ..     266     306 .. 0.94
   5 !   16.2   0.3   1.5e-06    0.0066      16      49 .]     308     341 ..     302     341 .. 0.93
   6 !   49.3   0.1   6.7e-17     3e-13       1      49 []     343     391 ..     343     391 .. 0.98
   7 !   27.8   0.0   3.5e-10   1.6e-06       1      49 []     368     418 ..     368     418 .. 0.87
   8 !   35.2   0.1   1.7e-12   7.4e-09       1      44 [.     420     463 ..     420     491 .. 0.94
   9 !   15.2   0.0   2.8e-06     0.013      17      35 ..     511     529 ..     504     534 .. 0.90
  10 !   17.4   0.0   5.9e-07    0.0026      23      49 .]     540     566 ..     539     566 .. 0.94
  11 !   47.2   0.0     3e-16   1.3e-12       1      49 []     568     616 ..     568     616 .. 0.98

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 3.8e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 Dr+i++ a+ +n + ++++s+++k D ++vl+Avk + +a++ +s+ +
  EFC36329.1  83 DRDIAWIALGSN-FKFRHISDRFKEDYQVVLQAVKYDTKAFELVSDRF 129
                 9**********8.88*****************************9976 PP

  == domain 2  score: 47.3 bits;  conditional E-value: 2.8e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D+ iv eav+++gs+lk++se+Lk + +i+lkA+k+n +a+ yas+ +
  EFC36329.1 132 DERIVFEAVRNCGSNLKFASERLKDNNQIILKAIKKNTSAIMYASKRF 179
                 788******************************************976 PP

  == domain 3  score: 35.4 bits;  conditional E-value: 1.4e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++ ++le vk n  +l+++s++L+ +  ivl+A+++n  +l+yas+ Lr
  EFC36329.1 213 NELLMLEFVKLNTRSLRKASDRLRDNQTIVLEAIRRNAMSLCYASDRLR 261
                 5789******************************************998 PP

  == domain 4  score: 28.5 bits;  conditional E-value: 2.1e-10
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 +v+eav++ +   ky+s++Lk +k++vlk++k+ g++++
  EFC36329.1 266 VVMEAVTQEPQMMKYASNRLKDNKQFVLKIMKSLGYSYD 304
                 69******************************9888875 PP

  == domain 5  score: 16.2 bits;  conditional E-value: 1.5e-06
     DUF4116  16 lkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                  +yls+ L+ D +i+++ +k++ ++l +ase L+
  EFC36329.1 308 VQYLSKLLQDDEQIIIEEIKRDQSPLFFASERLQ 341
                 59*****************************986 PP

  == domain 6  score: 49.3 bits;  conditional E-value: 6.7e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++Eiv++av +ng++l+ +se+Lk +  ivl+Av++ + al yas+ L+
  EFC36329.1 343 NEEIVMKAVNQNGMSLYCASERLKDNEKIVLEAVRNTSEALTYASNRLK 391
                 79*******************************************9986 PP

  == domain 7  score: 27.8 bits;  conditional E-value: 3.5e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng...talsyaseeLr 49 
                 ++ ivleav++ ++al+y+s++Lk D e+vl A   +g   +alsyase L+
  EFC36329.1 368 NEKIVLEAVRNTSEALTYASNRLK-DSELVLMAAICHGrlcKALSYASERLQ 418
                 688*********************.99998888776884545*******986 PP

  == domain 8  score: 35.2 bits;  conditional E-value: 1.7e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 ++ ivle vkkngs l y+s++Lk + +ivl+A+kq  ++++ +
  EFC36329.1 420 NELIVLESVKKNGSMLGYASDRLKYHEQIVLEAIKQERSSIENI 463
                 678*********************************99887655 PP

  == domain 9  score: 15.2 bits;  conditional E-value: 2.8e-06
     DUF4116  17 kylseeLknDkeivlkAvk 35 
                 +y+se+LknD +++lk + 
  EFC36329.1 511 EYCSERLKNDSQFMLKVLA 529
                 79*************9775 PP

  == domain 10  score: 17.4 bits;  conditional E-value: 5.9e-07
     DUF4116  23 LknDkeivlkAvkqngtalsyaseeLr 49 
                 L+ +k+++l+A+k n+ a++ ase Lr
  EFC36329.1 540 LSDNKQFMLEAIKLNCWAIDSASEQLR 566
                 6789********************998 PP

  == domain 11  score: 47.2 bits;  conditional E-value: 3e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+v+ a+++ng+ l+y+s++LknD+ iv  Avk++  +l+y+ e++r
  EFC36329.1 568 DEEVVKAAISQNGKTLQYVSDRLKNDITIVSSAVKSSVASLKYIGEKFR 616
                 9********************************************9987 PP

>> DBD_HTH  Putative DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.7   7.5e+03      13      25 ..     127     139 ..     127     140 .. 0.83
   2 !    4.3   0.0     0.008        36      13      26 ..     258     271 ..     258     273 .. 0.92
   3 !    7.5   0.0   0.00075       3.4      13      33 ..     388     409 ..     388     409 .. 0.86
   4 ?    2.2   0.0     0.036   1.6e+02      14      26 ..     416     428 ..     415     430 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.7
     DBD_HTH  13 DsldDkeLsiiea 25 
                 D++ D+e ++ ea
  EFC36329.1 127 DRFKDDERIVFEA 139
                 89****9888777 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.008
     DBD_HTH  13 DsldDkeLsiieat 26 
                 D+l D+e +++ea+
  EFC36329.1 258 DRLRDTEMVVMEAV 271
                 89**********98 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.00075
     DBD_HTH  13 DsldDkeLsiieatakG.IckA 33 
                 ++l D+eL++++a  +G +ckA
  EFC36329.1 388 NRLKDSELVLMAAICHGrLCKA 409
                 6899**********99966665 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.036
     DBD_HTH  14 sldDkeLsiieat 26 
                 +l D eL+++e++
  EFC36329.1 416 RLQDNELIVLESV 428
                 689********97 PP

>> CbiG_C  Cobalamin synthesis G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.5   6.8e+03       3      43 ..       2      42 ..       1      48 [. 0.83
   2 ?    1.5   0.0     0.095   4.3e+02      23      65 ..     111     152 ..      92     177 .. 0.75
   3 ?   -1.1   0.0      0.59   2.6e+03      29      59 ..     272     302 ..     260     319 .. 0.77
   4 ?    3.8   0.1     0.019        84      37      72 ..     360     394 ..     329     402 .. 0.75
   5 !    9.3   0.0   0.00036       1.6      21      73 ..     447     497 ..     432     509 .. 0.77
   6 ?   -0.6   0.0      0.43   1.9e+03      32      72 ..     556     595 ..     541     612 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.5
                EEEEE-SS--HHHHHHHHHHHHHHCT--GGGEEEEEESSCC CS
      CbiG_C  3 vGiGcrrgtsaeeieeaieealeeaglseeavaalatidlK 43
                +G   + g +++++ + i++ +e+++  ++++ +l+  d K
  EFC36329.1  2 IGTNTKPGLDRSQFTAIIKHRIEQNHQLISNIIGLCDCDDK 42
                56667788999999999999999999999999988888877 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.095
                 HHHHCT--GGGEEEEEESSCCSHHHHHHHHHHHCTSTEEEE-H CS
      CbiG_C  23 aleeaglseeavaalatidlKadepgllelaeklglplktfsa 65 
                 +l++ +++ +a  +l +   K de+ + e+++++g +lk+ s+
  EFC36329.1 111 VLQAVKYDTKAF-ELVSDRFKDDERIVFEAVRNCGSNLKFASE 152
                 555555555554.567888999999999999999998887654 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.59
                 --GGGEEEEEESSCCSHHHHHHHHHHHCTST CS
      CbiG_C  29 lseeavaalatidlKadepgllelaeklglp 59 
                  +e ++ + a+  lK +++ +l+++++lg +
  EFC36329.1 272 TQEPQMMKYASNRLKDNKQFVLKIMKSLGYS 302
                 5566778899999********9999999865 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.019
                 EEESSCCSHHHHHHHHHHHCTSTEEEE-HHHHHCHH CS
      CbiG_C  37 latidlKadepgllelaeklglplktfsaeeLaave 72 
                  a+  lK +e+ +le++++   +  t+++++L++ e
  EFC36329.1 360 CASERLKDNEKIVLEAVRNT-SEALTYASNRLKDSE 394
                 79999*************99.589999999998766 PP

  == domain 5  score: 9.3 bits;  conditional E-value: 0.00036
                 HHHHHHCT--GGGEEEEEESSCCSHHHHHHHHHHHCTSTEEEE-HHHHHCHHC CS
      CbiG_C  21 eealeeaglseeavaalatidlKadepgllelaeklglplktfsaeeLaavev 73 
                 + +le+ + ++++++++ +  lK  e  +lel+++    +k + + e+ + e+
  EFC36329.1 447 QIVLEAIKQERSSIENITSARLKDTETIILELVKDS--TMKHVHNLEIDEYEF 497
                 456777788899**********************99..566777777777775 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.43
                 GGEEEEEESSCCSHHHHHHHHHHHCTSTEEEE-HHHHHCHH CS
      CbiG_C  32 eavaalatidlKadepgllelaeklglplktfsaeeLaave 72 
                  a++  a+ +l+ de+ + +++++ g  l+++s    ++++
  EFC36329.1 556 WAID-SASEQLRDDEEVVKAAISQNGKTLQYVSDRLKNDIT 595
                 5553.478899999999999999999888887766555554 PP

>> ArsR  ArsR transcriptional regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1      0.25   1.1e+03     104     149 ..     127     173 ..      98     180 .. 0.74
   2 ?    0.5   0.1     0.092   4.1e+02     101     138 ..     255     292 ..     219     301 .. 0.60
   3 ?    5.9   0.2     0.002         9     101     156 ..     335     391 ..     318     394 .. 0.88
   4 ?    2.1   0.3      0.03   1.3e+02     103     147 ..     439     484 ..     415     495 .. 0.81
   5 ?    7.2   0.1   0.00081       3.6     101     155 ..     560     615 ..     543     619 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.25
        ArsR 104 eeleelvekiekeveegntsisdlsrklg.lsplfiralakrsekld 149
                 + +++ ++ + + v++    ++  s++l+  ++++++a+ k  + + 
  EFC36329.1 127 DRFKDDERIVFEAVRNCGSNLKFASERLKdNNQIILKAIKKNTSAIM 173
                 55666666667777777777777777764257888888888877665 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.092
        ArsR 101 msdeeleelvekiekeveegntsisdlsrklglsplfi 138
                    + l++++  +++ v+++ ++++  s++l+ ++ f+
  EFC36329.1 255 YASDRLRDTEMVVMEAVTQEPQMMKYASNRLKDNKQFV 292
                 34455666666666666666666666666666555555 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.002
        ArsR 101 msdeeleelvekiekeveegntsisdlsrklg.lsplfiralakrsekldvkGqrle 156
                    e l++ +e ++k v+++ +s+   s++l+  +++++ a+ + se l++  +rl+
  EFC36329.1 335 FASERLQDNEEIVMKAVNQNGMSLYCASERLKdNEKIVLEAVRNTSEALTYASNRLK 391
                 567999**********************99962578999**********99888876 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.03
        ArsR 103 deeleelvekiekeveegntsisdlsr.klglsplfiralakrsek 147
                  + l+  ++ + + +++++ si++++  +l+ ++++i  l+k s+ 
  EFC36329.1 439 SDRLKYHEQIVLEAIKQERSSIENITSaRLKDTETIILELVKDSTM 484
                 56777788888999**********9752678888888888887765 PP

  == domain 5  score: 7.2 bits;  conditional E-value: 0.00081
        ArsR 101 msdeeleelvekiekeveegntsisdlsrklglsplfiralakrs.ekldvkGqrl 155
                 +  e+l++ +e +++ ++++ + ++ +s++l+ + +++ + +k s  +l++ G++ 
  EFC36329.1 560 SASEQLRDDEEVVKAAISQNGKTLQYVSDRLKNDITIVSSAVKSSvASLKYIGEKF 615
                 56799*************************************98824688888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (649 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1023  (0.0570584); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.52
# Mc/sec: 3744.88
//
Query:       EFC36330.1  [L=1090]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   4.7e-107  359.6   8.5   6.1e-107  359.2   8.5    1.1  1  Sec1             Sec1 family
    4.5e-18   65.6   3.3    1.6e-17   63.8   3.3    2.0  1  Pur_ac_phosph_N  Purple acid Phosphatase, N-terminal domain
    1.5e-16   61.5   4.7    4.8e-16   59.9   4.7    1.9  1  Metallophos      Calcineurin-like phosphoesterase
    2.1e-09   38.1   1.1    6.2e-09   36.6   1.1    1.8  1  Metallophos_C    Iron/zinc purple acid phosphatase-like prote
  ------ inclusion threshold ------
      0.041   13.7   0.3        3.3    7.5   0.0    2.7  3  LexA_DNA_bind    LexA DNA binding domain


Domain annotation for each model (and alignments):
>> Sec1  Sec1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  359.2   8.5  1.7e-110  6.1e-107       1     574 [.     455    1040 ..     455    1041 .. 0.84

  Alignments for each domain:
  == domain 1  score: 359.2 bits;  conditional E-value: 1.7e-110
                  EEEEE-HHHHHHHHTT--HHHHHTTTEEETT..T--S-.....BTTSEEEEEE-S-HHHHHHHHH.......HHHSS.................... CS
        Sec1    1 KvLvlDkelskilssvlkvsdlleegVtkieklkkrepskrealphlkaiyflrptkenidrlak.......dfisa.................... 70  
                  K+LvlD++l+++l++v   + l+e gV k++kl  ++ + +++  ++  +y++rp+ + ++ +a+       +   +                    
  EFC36330.1  455 KILVLDEQLIGPLGLVAPLALLKELGVKKLFKL--NDRTFDTNFANI--VYIVRPKMHLMKWVANqvsywvkQ---Kedldrmmseklkekkntknk 544 
                  9**********************77******99..44455999****..***************977776651...144566677777778888899 PP

                  ............-SBS-EEEEESS---...HHHHHHHHH..SG.GGGEEEEE----SEEEETTEEE-STTHHHHSTTG.....GG.......--HHH CS
        Sec1   71 ............rrykeyhifftprls...eslleglakadeevvkkvklkelnldfvplesdlfslnpelplsfrdlyldndnsaleeeieslldr 152 
                                  ++h++ +p+ s    ++l++l      v ++++++e++ld++++++ l sl  elp+sf+++ ld+d s+l+         
  EFC36330.1  545 kqqpeetneetyTPPTNFHLYLLPKTSlicVDILKDLG-----VYPHLRISEYPLDLIVFDNYLMSL--ELPSSFKECELDGDFSSLYY-------- 626 
                  999******9999999********99977777777665.....24555599****************..9***************9999........ PP

                  HHHHHHHHHHHH.-..--EEEE-TT-HHHHHHHH..........HHHHTTT--SS--EEEEE-GGG-SSTTTS---BHHHHHHHHS--BTEEEEEE- CS
        Sec1  153 iakgLlsvllsl.ekkiPiirykgsaasmvakkladelkekidskknfesessrqrpvLiIlDRsvDlvtpllhqwTYqaliddllgglnnnnvvle 248 
                  +a+++++  l+   + iP++ ++gs a++v++ ++ ++++++ s   + + s  +  +Li++DR+vDl+tp+l+q+TY+++id+llgg+ n    ++
  EFC36330.1  627 VARSIMK--LQSyFGLIPNVKFIGSGATHVSEMIM-RMRKEVGS---QAFASVPEINTLILIDRNVDLITPMLNQFTYEGMIDELLGGITNTLFTTQ 717 
                  *******..888345*************7777774.44555554...33337778888****************************98855555555 PP

                  -SS.SEEEEEE--TT..-TTHHHHTTSBHHHHHHHHHHHHHHHHHHHHTTT....-...TTHHHHHHHHHH-GGGHHHHHHHHHHHHHHHHHHHHS- CS
        Sec1  249 eep.keekeaelvesssDeffaelrhlnfgevgeklkkeakeyqeenekkrn.gak...esiadlkkfvaklpelqeekkklskHtnlaeellkevk 340 
                  ++p + +  ++++++ssD +f++lrhln + +g +++++a e+++ ++k r+ +++    si+++k++ + lp+ qe+kk l++Ht+++ e+ +++ 
  EFC36330.1  718 RVPeAATIAKKIALNSSDNVFNRLRHLNHNRAGIAINEMAIEFKSREDKAREiKTSdskVSIEKIKEVTKMLPQIQEDKKYLELHTKMMLEIRSIIG 814 
                  5559889999999999****************************8875556556667889************************************* PP

                  HHH.HHHHHHHHHHHHSS--.B--..-HHHHHHHH-TTS-H.HHHHHHHHHHHH...-B.-HT--GG....GGHHHHGGGGG........---.BGG CS
        Sec1  341 krkldellelEqdlatgesdkkikekkvieeliaddeptseledklRLlllyslvegglkekelkellrelvqsalygleylktlrsleklgllkkr 437 
                  k  +++l++ + +++ ge++k+i+e+  iee+i+++ p   l+++lR ++lysl++gg+k+k +++l+re++q + ygl+ l tl++lek+g+l+k+
  EFC36330.1  815 KVPFRRLIQTQKNVLDGEDEKEIIEY--IEETIDKQLP---LTNVLRVICLYSLINGGIKNKVFEKLRREIIQ-S-YGLQALPTLNNLEKIGMLRKQ 904 
                  ***************97645999999..*****99888...89******************************.9.******************999 PP

                  G-------...............---------S............TT-----HHHHHHHHHTT.T-S-TTTS-BSS-GGGS---------------- CS
        Sec1  438 kgkksskkkss........lklikeeedeesnyd.........lsgvsryaPllvrlvealik.gkklssespslskkdpsqeesssslrsakktns 516 
                  ++k+ s+ +          +        e++n++         ++    y P++v lve+++  +k ++  +p lsk +p        l ++ +++ 
  EFC36330.1  905 DSKSVSNWNLLkktfnlvdE-----AAMERTNEEdgqydphlvYNV---YCPITVALVEHAMTeEKGWRRVEPVLSKLAPG-------LYGELSQTG 986 
                  99888888777999666542.....333333333444556665555...*************7245566666666666553.......444555555 PP

                  ----------S-EEEEEEEEEE-HHHHHHHHHHT...TSSSEEEEEEEEE--HHHHHH CS
        Sec1  517 askesaekkkkqrviVffvGGvTysEiralrllskqekknkeiiigttsilnpksfle 574 
                  ++  +     k++v+V+f+GGvT++Ei+a+ +l++++ +  e ii+tt+++n+++fle
  EFC36330.1  987 SQDTQLG---KKVVLVYFIGGVTFAEISAITYLNERS-NDCEYIIATTKLTNGSTFLE 1040
                  5555555...5***********************986.6699**************97 PP

>> Pur_ac_phosph_N  Purple acid Phosphatase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.8   3.3   4.5e-21   1.6e-17       1      94 []      22     122 ..      22     122 .. 0.87

  Alignments for each domain:
  == domain 1  score: 63.8 bits;  conditional E-value: 4.5e-21
  Pur_ac_phosph_N   1 peqvhlsltedtstsmtvsWitpe....ktkksvvrygtssdalestae..atsstyettnyksgyshkatltgLepgttYyYrvgddeg..gw 86 
                      p+qvhl+lt  +s++m+vs++t        +k++v y+t+++ ++ ++   ++ st+  ++ k+gy h+++l +Le +t+YyY++g +++   +
       EFC36330.1  22 PSQVHLALTR-NSREMIVSFHTEGydkdVLGKAQVMYSTNENFQDYQVAhlGSVSTTYGESAKTGYEHHVLLVDLEYSTKYYYKCGFTKStdIQ 114
                      89********.***********75444377999**********88877622455555569999*************************7778** PP

  Pur_ac_phosph_N  87 SevysfkT 94 
                      Sevy f+T
       EFC36330.1 115 SEVYYFHT 122
                      ******98 PP

>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.9   4.7   1.3e-19   4.8e-16      23     204 .]     160     363 ..     144     363 .. 0.69

  Alignments for each domain:
  == domain 1  score: 59.9 bits;  conditional E-value: 1.3e-19
                  HHHHHHHHHTTESEEEEESTSSSSS.........HHHHHHHHHHHHHHHHTSEEEEEC-TTS......CHHH.HHHHHHHHHHHHHHHHEHHHCEEET CS
  Metallophos  23 kllddllreekpdlvllaGDlvdrg.........dlekellellaalvkypipvylllGNHe......gfee.ellnkygylgifsepwrsdaevfnn 104
                   ++d+  +++k+ +v ++GD+ + +          + k ++++l+ + +y  p++++ GNHe       ++e e++ k  ++  + ++ +  a   n 
   EFC36330.1 160 SFYDKSDSKHKNMFVYHLGDIGYANdfagaqyqfIWTK-YMKMLSDFMPY-APYMVCVGNHEkgpknhPYDEfEIPFKAYNSRFYMPGRNESAIGHNM 255
                  5667778889**********555555588977777777.77777777776.***********865555444444444444444444444444666677 PP

                  SEEEEEETTEEEEEEEESECEEETHHHHHHHHHHHSCHHHHCC.HHHHHH...HHHHTTCSEEEEEESSESS............CSSSCSCCHHHHH. CS
  Metallophos 105 lplaslgsgslkvlllhGgspellvsldklgslnleleapepg.dewlkd...lekrekadwvivlgHsply............rgsgylfgdeale. 185
                  + ++++g    +++ ++ +     +++  ++  ++++     +  +wl +   +++r+k++w++v+gH+p+y              +           
   EFC36330.1 256 WHVFEYGPI--TFVAVDTE-----TNFPGAHFGKYDDHFHG-EqLKWLDEtlsQVDRKKTPWLVVVGHRPIYsstkefsnehgdPIGDSKV-----Lq 340
                  777777777..66666666.....33333333333333333.248888888888******************8887777444443333334.....26 PP

                  ....HHHHHTTESEEEEESSSSE CS
  Metallophos 186 ....dllkkygvdlvisGHtHvy 204
                      ++ +ky+ d+   GH+H y
   EFC36330.1 341 dafeEVMYKYKTDIFMVGHVHSY 363
                  666599***************86 PP

>> Metallophos_C  Iron/zinc purple acid phosphatase-like protein C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6   1.1   1.7e-12   6.2e-09       1      61 [.     385     451 ..     385     452 .. 0.86

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 1.7e-12
  Metallophos_C   1 ApvhiviGaAGndegdafkgeppqpews.afrstdyGygrltv.hNat....hLlwefvrssdgkvi 61 
                    +p+hiv+G++Gn+eg++  +  ++ +ws   + +d Gyg+l+  +++     +L++ +++s++g+vi
     EFC36330.1 385 SPIHIVNGGGGNIEGQTKAESFHNHDWSaDIFYKDEGYGILHTnYDEKtkvySLKFNYHESKTGSVI 451
                    69*************6656677788***766699*********544449999************998 PP

>> LexA_DNA_bind  LexA DNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.0   0.00093       3.3      11      51 ..     705     745 ..     703     751 .. 0.89
   2 ?   -3.2   0.1       2.1   7.6e+03       9      21 ..     835     847 ..     833     848 .. 0.87
   3 ?    3.0   0.0     0.023        84      14      63 ..     863     908 ..     851     909 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00093
                    HHHHHHHHHHHHSS---HHHHHHHHTS-.HHHHHHHHHHHH CS
  LexA_DNA_bind  11 vldlikasieetgypPsireiaralglkSpsaveehLkaLe 51 
                    +l  i + + +t+  P  + ia+++ l+S+  v ++L+ L+
     EFC36330.1 705 LLGGITNTLFTTQRVPEAATIAKKIALNSSDNVFNRLRHLN 745
                    66678888999999************************997 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.1
                    HHHHHHHHHHHHH CS
  LexA_DNA_bind   9 revldlikasiee 21 
                    +e++++i++ i++
     EFC36330.1 835 KEIIEYIEETIDK 847
                    79*******9987 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.023
                    HHHHHHHHHSS---HHHHHHHHTS-.HHHHHHHHHHHHHTTSEE-GGG-C CS
  LexA_DNA_bind  14 likasieetgypPsireiaralglkSpsaveehLkaLerKGyierdpgkp 63 
                    li+  i+++ +   +rei +  gl+    +   L+ Le+ G+++ ++ k+
     EFC36330.1 863 LINGGIKNKVFEKLRREIIQSYGLQ----ALPTLNNLEKIGMLRKQDSKS 908
                    566666666677779*********9....8899***********999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1090 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1019  (0.0568353); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.87u 0.37s 00:00:01.24 Elapsed: 00:00:00.54
# Mc/sec: 6079.05
//
Query:       EFC36331.1  [L=1813]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-29  102.4   0.0    7.9e-16   58.6   0.0    5.0  4  Peripla_BP_6   Periplasmic binding protein
    1.1e-18   67.5   0.0      5e-18   65.4   0.0    2.1  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.3e-16   60.7   4.5    7.8e-08   31.8   0.1    2.8  3  ANF_receptor   Receptor family ligand binding region


Domain annotation for each model (and alignments):
>> Peripla_BP_6  Periplasmic binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   1.2e-05      0.07      21      62 ..       1      43 [.       1      48 [. 0.91
   2 !   58.6   0.0   1.3e-19   7.9e-16      65     216 ..      72     228 ..      69     353 .. 0.79
   3 ?    3.1   0.0     0.011        64      22     144 ..     493     626 ..     489     698 .. 0.76
   4 !   20.8   0.0   4.3e-08   0.00025      61     150 ..     969    1067 ..     924    1071 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.2e-05
                  HHHHHHHHHHHHHHTTEETTE.EEEEEEEE-TTSHHHHHHHHH CS
  Peripla_BP_6 21 llagaqaafeeiNaaGGinGr.kielverDdaydpdraaeaar 62
                  +++g+ aaf eiN  GG+ G  k++l++ Dd ydp  ++++++
    EFC36331.1  1 MRNGILAAFHEINSIGGVWGSkKLKLLSLDDNYDPVSTLQNTN 43
                  689****************9659************99998875 PP

  == domain 2  score: 58.6 bits;  conditional E-value: 1.3e-19
                   HHCT--SEEEE-BSHHHHHHHHHHHHHHT-EEEESS-HHCC....TTSTTEEESS--HHHHHHHHHHHHHHHTTSCEEEEEEESSHHHHHHHHHHHH CS
  Peripla_BP_6  65 vdqdgvdalvgplssavaaavaevlakdgvpvigpagltge....kcspyvfslgpsysaqasalveylakelggkkvalvyadyafgregiaalka 157
                   v++ +v++l+g++++++++av + + +++vp++  +++ g+    + + +v++l++sy+++++a+++yl++e  ++++ ++y++++fg +g  ++++
    EFC36331.1  72 VNDVKVFGLLGYVGTPTVQAVYSDVVAKNVPLVASFTGVGWlrysPFYSNVINLRASYDDETAAMIDYLINEKLIRRISVFYQNDSFGLAGLSGVQR 168
                   56679****************9999999******8877776444477999*********************999*********************99 PP

                   HHHCC.TEEEEEEEEE-TTHHHHHHHHHHHHTTT-SEEEEESSHHHHHHHHHHHHHTT-S CS
  Peripla_BP_6 158 aakaa.GgevvgeepvplgttdfsaqvlqikaagadavllagtgadlaallkaaaeaGld 216
                   ++  +  + +  + +++ gt +++++ ++i a ++ a++++gt+a++a+++k +++  ++
    EFC36331.1 169 SLVNYlNIPIRSTSYYTRGTLNVENAFQEIGAGKPAAIICIGTFAPIAKFIKMVKDLAFN 228
                   99988688899*****************************************99887766 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.011
                   HHHHHHHHHHHHHTTEETTEEEEEEEEE-TTSHHHHHHHHHHHHHCT--SEEEE-BSHHHHHHHHHHHHH.........HT-EEEESS-HH.....C CS
  Peripla_BP_6  22 lagaqaafeeiNaaGGinGrkielverDdaydpdraaeaarrlvdqdgvdalvgplssavaaavaevlak.........dgvpvigpaglt.....g 104
                   ++g+ +af   N++    + k+el++  ++++ d+ ++++++++++ ++ alvg+  s + + ++e   k         +++ +ig a++       
    EFC36331.1 493 RKGILMAFTIYNQGLSSSDSKLELLTQ-YHSNKDELISNTKEFIETHDALALVGY--STDHFSLVESSGKiniatnpqfANISLIGGASTInsmklR 586
                   677777777777777667778888775.78999*********************8..6778899998888444444555555666644333233333 PP

                   CTTSTTEEESS--HHHHHHHHHHHHHHHTTSCEEEEEEES CS
  Peripla_BP_6 105 ekcspyvfslgpsysaqasalveylakelggkkvalvyad 144
                   ++ +++++++  s   q++++vey ++++  +++ ++y+ 
    EFC36331.1 587 NPFTRNIIHAHSSIFEQLATIVEYSMNQEASSRFSIIYSK 626
                   5677888888888889999999998888887777777764 PP

  == domain 4  score: 20.8 bits;  conditional E-value: 4.3e-08
                    HHHHHHCT--SEEEE-....BSHHHH...HHHHHHHHHHT-EEEESS-HH...CCTTSTTEEESS--HHHHHHHHHHHHHHHTTSCEEEEEEESS CS
  Peripla_BP_6   61 arrlvdqdgvdalvgp....lssava...aavaevlakdgvpvigpaglt...gekcspyvfslgpsysaqasalveylakelggkkvalvyady 145 
                    ++ l+d++ v+a++g     +ss++      ++++l+++++p+i+  +++    ++ +py++++gps  +qa ++++y+++  g  ++alvy ++
    EFC36331.1  969 VNSLIDKNRVFAIIGSefifTSSDISrefDSIRSTLETKQIPWINSYSGSmelRKPYTPYFVNVGPSVVDQAISFFNYFKQ-NGTVNLALVYEND 1062
                    66788888888888743332333333111456778888*******555553355899*********************766.6999********* PP

                    HHHHH CS
  Peripla_BP_6  146 afgre 150 
                    +f + 
    EFC36331.1 1063 PFYTN 1067
                    *9876 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.45   2.7e+03      11      41 ..    1247    1277 ..    1244    1292 .. 0.85
   2 !   65.4   0.0   8.4e-22     5e-18       7     150 ..    1406    1560 ..    1400    1573 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.45
  Guanylate_cyc   11 ilFadIvgftalssahspievvklLnelyar 41  
                     il ++I++ +++s ++s i   +lLn++y++
     EFC36331.1 1247 ILITSIEQAKSISGQTSNITPSDLLNSIYSN 1277
                     8899************************986 PP

  == domain 2  score: 65.4 bits;  conditional E-value: 8.4e-22
  Guanylate_cyc    7 devtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevavesk... 97  
                      + +  F+dI+++t l++    +++ ++L  +++ +++ ld  ++ +vkt Gd++ vv++ p   ++++ ++++++ d+l a            
     EFC36331.1 1406 GKLACCFTDIQNSTVLWQSN-EKAMREALIIHNQIMRKNLDLCNGFEVKTQGDSFFVVFKNP---TDALDWCVSVQHDLLTAKWPSDLLGLwdc 1495
                     567789************88.89***************************************...999********999999855555543567 PP

  Guanylate_cyc   98 .............eglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvsee 150 
                                   g++vr G+h+G      + ++ +r d++G+ vn+ +r+es++ +g+i vse+
     EFC36331.1 1496 rpewdnatkeiiwSGVRVRMGLHYGAAEYVFD-KVVKRPDYFGTCVNTSARVESVAIGGQILVSED 1560
                     899999999****************9988888.889999*************************96 PP

>> ANF_receptor  Receptor family ligand binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.8   0.1   1.3e-11   7.8e-08       5     203 ..       4     229 ..       1     305 [. 0.90
   2 ?   -3.4   0.0      0.68     4e+03     147     187 ..     652     692 ..     620     704 .. 0.77
   3 !   28.9   1.3   9.6e-11   5.8e-07      17     209 ..     943    1145 ..     936    1235 .. 0.81

  Alignments for each domain:
  == domain 1  score: 31.8 bits;  conditional E-value: 1.3e-11
                   HHHHHHHHHHT-TTSSTTEEEEEEEEE-TT-HHHHHHHHHHHCCC.C..........................EEEEEE-SSHHHHHHHHHHHCCTT CS
  ANF_receptor   5 AmklAveeinsdpnllpgiklgyeiidtccdfslaleaaldflkg.k..........................vvaviGpssssvsdavaslanlfk 74 
                    +  A+ eins +++ ++ kl +  +d+++d++ +l+ ++ fl +                            v++++G ++  ++ av s   + +
    EFC36331.1   4 GILAAFHEINSIGGVWGSKKLKLLSLDDNYDPVSTLQNTNYFLYNiTppntslnyanvfssgkyedrnvndvkVFGLLGYVGTPTVQAVYSDVVAKN 100
                   67889***************************************9659************************************************* PP

                   -EEEESS---GG.GG-TTTTTTEEESS--CHHHHHHHHH.HHHHTT--EEEEEEESSHHHHHHHHHHHHHHHHTT.-EEEEEEEESTCHHHCHHHHH CS
  ANF_receptor  75 iPvisygstspe.lsdknryptflrtvpsdtsqaqAivd.ilkhfgWkkvaliysdddygesglqaleeeleerg.icvalkekipessnddevvrk 168
                   +P++  ++t    l+   +y+ +++++ s      A++d ++++   +++++ y++d+ g+ gl  ++ +l ++  i++    +++   + +  v++
    EFC36331.1 101 VPLV-ASFTGVGwLRYSPFYSNVINLRASYDDETAAMIDyLINEKLIRRISVFYQNDSFGLAGLSGVQRSLVNYLnIPIRSTSYYT---RGTLNVEN 193
                   ****.7888889999999*****999999999*****9956789*************************7777655****999999...66666666 PP

                   HHHHHTT.T--EEEEEE-HHHHHHHHHHHHHTTS-S CS
  ANF_receptor 169 llkeiks.karvivlfcssedarellkaarrlgltg 203
                     +ei+  k+ +i++      + +++k++++l +++
    EFC36331.1 194 AFQEIGAgKPAAIICIGTFAPIAKFIKMVKDLAFNS 229
                   6667788788899999999***********998776 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.68
                   T-EEEEEEEESTCHHHCHHHHHHHHHHTTT--EEEEEE-H..H CS
  ANF_receptor 147 gicvalkekipessnddevvrkllkeikskarvivlfcss..e 187
                   + c+  +++++   ++d++v++l+   +s+++v+++ ++s  +
    EFC36331.1 652 SACIDGSNSYS-YASIDSIVDSLR-YNGSNPQVVIFAFPSnvD 692
                   46777777777.567999999996.667799999999887543 PP

  == domain 3  score: 28.9 bits;  conditional E-value: 9.6e-11
                    TTSSTTEEEEEEEEE-TT-HHHHHHHHHHHCCCC.EEEEEE.......-SSHHHHHHHHHHHCCTT-EEEESS---GGGG-TTTTTTEEESS--C CS
  ANF_receptor   17 pnllpgiklgyeiidtccdfslaleaaldflkgk.vvaviG.......pssssvsdavaslanlfkiPvisygstspelsdknryptflrtvpsd 103 
                    +  +++i+l +e   t  +  + ++++++++ ++ v+a+iG       +  s+++d + s +++ +iP i   s s el++    p+f+++ ps 
    EFC36331.1  943 GYSSKNIQLVIEYYSTDEEKFNLPNKVNSLIDKNrVFAIIGsefiftsSDISREFDSIRSTLETKQIPWINSYSGSMELRKPYT-PYFVNVGPSV 1036
                    455678888888899999999999********955**********98877889****************************999.*********9 PP

                    HHHHHHHHHHHHHTT--EEEEEEESS.HHHHHHHHHHHHHHHHTT-EEEEEEEESTCHHHCHHHHHHHHHHTTT--EEEEEE-H.....HHHHHH CS
  ANF_receptor  104 tsqaqAivdilkhfgWkkvaliysdd.dygesglqaleeeleergicvalkekipessnddevvrkllkeikskarvivlfcss.....edarel 192 
                      qa  +++ +k+ g    al+y++d  y +  + +++e  + ++i++++ + ++ ++++ + + +l ++++ + +v +++        + +++ 
    EFC36331.1 1037 VDQAISFFNYFKQNGTVNLALVYENDpFYTNMAISEIVEYCRIESIPISFTQGVY-NTSIADQIISLFSNARIEKDVAIMVLARdsnsaSIIKHS 1130
                    9999999999999999**********88***************************.666666666666555555555555444445666666666 PP

                    HHHHHHTTS-STTEEEE CS
  ANF_receptor  193 lkaarrlgltgeeyvwi 209 
                    + aa++l+++ +   ++
    EFC36331.1 1131 ILAAQKLNIDKK--LYF 1145
                    778888888874..444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.76u 0.26s 00:00:01.02 Elapsed: 00:00:00.42
# Mc/sec: 13008.97
//
Query:       EFC36332.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1025  (0.0571699); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1395.62
//
Query:       EFC36333.1  [L=377]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.21   11.3   6.1       0.14   11.8   1.9    2.2  2  Sclerostin  Sclerostin (SOST)
        1.1    9.4   6.5       0.13   12.2   2.1    1.9  2  AT_hook     AT hook motif


Domain annotation for each model (and alignments):
>> Sclerostin  Sclerostin (SOST)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.1     0.044   3.9e+02      31      59 ..      47      76 ..      30      86 .. 0.66
   2 ?   11.8   1.9   1.6e-05      0.14     120     189 ..     287     356 ..     273     363 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.044
                XXXXXXXXXXXXXXXXXXX.XXXXXXXXXX CS
  Sclerostin 31 vekpvqepennstlnrarn.GGrrpessld 59
                ++ +  +++n st+ r+ n GG   +++  
  EFC36333.1 47 SSSSSCNSNNTSTIARTSNnGGSISSNRST 76
                455666888999999976515555555533 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 1.6e-05
                 ----EEEEEEEEEEEEB-TTSSSEEEEEEEEEEEE---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Sclerostin 120 efrcvndktrtqriqlqcedGatrtykvtvvtsckckrytrqhnesshkdesaskakPqkarkerekkrk 189
                 + rc   k rt r +l+ +  + ++ k ++vts +     ++h+ s       ++ +P+k+  + +k ++
  EFC36333.1 287 KDRCKISKKRTTRPRLKFQKETDKSIKFNLVTSEELAASLQFHETSAPTSGKRNRGRPKKSDSSPQKPKA 356
                 559********************************************99999999***887665444443 PP

>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       1.5   1.3e+04       6       8 ..     299     301 ..     299     304 .. 0.78
   2 ?   12.2   2.1   1.5e-05      0.13       1      11 [.     338     348 ..     338     350 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.5
     AT_hook   6 RPr 8  
                 RPr
  EFC36333.1 299 RPR 301
                 898 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 1.5e-05
     AT_hook   1 kRkRGRPrKaa 11 
                 kR RGRP+K+ 
  EFC36333.1 338 KRNRGRPKKSD 348
                 8********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1203  (0.067098); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2401.25
//
Query:       EFC36334.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-25   90.2  35.3    1.1e-25   90.2  35.3    1.6  2  Snf7            Snf7
  ------ inclusion threshold ------
       0.14   12.4   0.4       0.31   11.3   0.4    1.5  1  AlkA_N          AlkA N-terminal domain
       0.53   10.5   4.2        4.7    7.5   0.1    2.6  2  Tctex-1         Tctex-1 family
        4.1    7.4   9.3        0.4   10.6   0.8    2.8  2  RNA_pol_Rpb1_4  RNA polymerase Rpb1, domain 4


Domain annotation for each model (and alignments):
>> Snf7  Snf7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.2  35.3   2.4e-29   1.1e-25       1     160 [.      18     181 ..      18     199 .. 0.93
   2 ?   -2.1   1.9      0.57   2.5e+03     135     147 ..     193     205 ..     183     211 .. 0.65

  Alignments for each domain:
  == domain 1  score: 90.2 bits;  conditional E-value: 2.4e-29
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTT-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        Snf7   1 eairsLrkaerkldkkqeslekkikkleaelkklakkgnkdralllLKqkkryekqldqldnqlanleqvslaienlksnkevlnamkqgakamkamnk 99 
                 e+++ L+ + r++d+ ++++e ++ k+++++k + kkg++d a+++++++++++k +++l  ++a++++v l+++++ ++ +v+ a++++a +mk mn+
  EFC36334.1  18 EWKKGLKSEVRNMDRGIRKIEMEEIKVKNNIKMMVKKGQEDNAKIVARELIKTRKAKERLIRTKAQMNSVILQLDQQVQQLRVMGALQKSADVMKCMNE 116
                 5778899******************************************************************************************** PP

                 CTCCHHHHHHHHHHHHHHHHHTCHHHHHHHHHTT-..GGTTHHHHHHHHHHHHHHHHHCSH...H CS
        Snf7 100 kvdidkidklmdeiedqmekaeeisEalsrsldda..deedEeeleaeLdaLeqelgdeell..d 160
                  +++++++ +m++++++meka+ i+E++++ ++d+  de  Ee  ++e+++++ e++++  +   
  EFC36334.1 117 MMKLPDLQATMRNMSKEMEKAGLIEEMVDDMMEDVfeDEDVEEAADEEVSEVLNEILENVKStrV 181
                 ************************************888889999**********9987654442 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.57
                 GGTTHHHHHHHHH CS
        Snf7 135 deedEeeleaeLd 147
                 +ee+E+e e eL+
  EFC36334.1 193 EEEEEDESELELQ 205
                 5566666666665 PP

>> AlkA_N  AlkA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.4   6.9e-05      0.31      33      96 ..      72     135 ..      58     146 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6.9e-05
      AlkA_N  33 dsygRtlrldgakGvvevrhepeksalkvrlslsdlraleaviarvrrllDLdadpeaieaaLd 96 
                 ++ +R +r++++   v ++ +++ ++l+v  +l++ +++ +++++  +l DL+a +++++++++
  EFC36334.1  72 KAKERLIRTKAQMNSVILQLDQQVQQLRVMGALQKSADVMKCMNEMMKLPDLQATMRNMSKEME 135
                 46789999999999999*****************************************999983 PP

>> Tctex-1  Tctex-1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   1.3     0.018        80      36      81 ..      63     109 ..       9     130 .. 0.74
   2 ?    7.5   0.1     0.001       4.7       2      43 ..     140     179 ..     139     191 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.018
                 HHHHHHHHTS.SS...SCEEEEEEEEEETTTS-EEEEEEEES-TTT- CS
     Tctex-1  36 ilkalksestele.lpryKfivnvtivqkkgqgmhsasgaywdektD 81 
                 + ++l++ ++ +e l r K  +n++i+q  +q  ++ +    +++ D
  EFC36334.1  63 VARELIKTRKAKErLIRTKAQMNSVILQLDQQVQQLRVMGALQKSAD 109
                 4455555533333488999999****997777555555544444444 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.001
                 HHHHHHHHHHHHHCTSSS--CCCHHHHHHHHHHHHHHHHHHH CS
     Tctex-1   2 lkqiakealesalesaesYdhekveqwnstiinsilkalkse 43 
                 +++++++++e+++e+++   +e +++ +s++ n+il+++ks 
  EFC36334.1 140 IEEMVDDMMEDVFEDED--VEEAADEEVSEVLNEILENVKST 179
                 57899999999999987..8889999999999****999955 PP

>> RNA_pol_Rpb1_4  RNA polymerase Rpb1, domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.8   8.9e-05       0.4      15      58 ..       9      55 ..       3      63 .. 0.80
   2 ?    0.5   1.9      0.12   5.6e+02      22      24 ..     152     155 ..      71     194 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 8.9e-05
                    THCHHHHHHHHHHHHHHHHHHH...HHHHHHHCSTTTSHHHHHHHCT CS
  RNA_pol_Rpb1_4 15 gksleelfeakinkilnkardk...agkiaskslaasNsiliMvksG 58
                    +k+ eel+++  + +++++r+    ++ki  ++++ +N+i++Mvk G
      EFC36334.1  9 KKTPEELAKEWKKGLKSEVRNMdrgIRKIEMEEIKVKNNIKMMVKKG 55
                    5677889999999999999988666666667777647*******987 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.12
                     HH.H CS
  RNA_pol_Rpb1_4  22 fe.a 24 
                     fe +
      EFC36334.1 152 FEdE 155
                     3321 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2378  (0.132634); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 1328.09
//
Query:       EFC36335.1  [L=563]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.6e-06   26.7   1.9    4.3e-06   26.0   0.9    2.0  2  IQ         IQ calmodulin-binding motif


Domain annotation for each model (and alignments):
>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.32   5.7e+03      11      18 ..     310     317 ..     309     318 .. 0.86
   2 !   26.0   0.9   2.4e-10   4.3e-06       2      21 .]     465     484 ..     464     484 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.32
                 HHHHHHHH CS
          IQ  11 wRGylaRk 18 
                 wR  l++k
  EFC36335.1 310 WRSQLTKK 317
                 9***9987 PP

  == domain 2  score: 26.0 bits;  conditional E-value: 2.4e-10
                 HHHHHHHHHHHHHHHHHHHH CS
          IQ   2 kaaikIQaawRGylaRkryk 21 
                 +aa+kIQ++wR +laR++ k
  EFC36335.1 465 QAATKIQSQWRSFLARRYMK 484
                 79***************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (563 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1219  (0.0679904); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.48
# Mc/sec: 3541.26
//
Query:       EFC36336.1  [L=434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.4e-37  122.1  56.6    0.00017   21.4   0.1   16.2 16  LRR_6            Leucine Rich repeat
    2.8e-21   75.0  46.2    1.9e-05   24.3   5.9    7.7 12  LRR_8            Leucine rich repeat
      9e-19   67.3  54.1     0.0056   17.1   5.7   10.3 13  LRR_4            Leucine Rich repeats (2 copies)
    3.7e-07   29.8  16.8      0.026   14.0   4.1    4.5  5  LRR_9            Leucine-rich repeat
    4.5e-06   26.5  31.3        8.9    7.3   0.1   12.5 11  LRR_1            Leucine Rich Repeat
  ------ inclusion threshold ------
        1.3    8.8   6.6         18    5.2   0.1    4.2  4  Ribosomal_L12_N  Ribosomal protein L7/L12 dimerisation domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.1    0.0013         4       4      16 ..       3      15 ..       1      17 [. 0.91
   2 !   14.4   0.0   9.9e-06      0.03       5      23 ..      47      65 ..      46      66 .. 0.94
   3 !    7.4   0.3    0.0018       5.2       3      22 ..      69      88 ..      67      90 .. 0.82
   4 !    7.0   0.2    0.0023         7       5      20 ..      95     110 ..      91     113 .. 0.89
   5 !    7.4   0.5    0.0017       5.2       2      23 ..     116     137 ..     115     138 .. 0.91
   6 !   18.9   0.1   3.5e-07    0.0011       2      23 ..     140     161 ..     139     162 .. 0.90
   7 ?   -0.9   0.1      0.82   2.4e+03       4      23 ..     166     185 ..     164     186 .. 0.77
   8 !    7.9   0.1    0.0012       3.6       5      24 .]     191     210 ..     188     210 .. 0.86
   9 !   14.3   0.2     1e-05     0.031       3      20 ..     213     230 ..     211     233 .. 0.87
  10 !    7.3   0.5    0.0018       5.3       4      17 ..     238     251 ..     235     252 .. 0.91
  11 !   10.8   0.1   0.00014      0.41       5      24 .]     261     280 ..     260     280 .. 0.92
  12 ?    4.4   0.0     0.016        47       5      21 ..     285     301 ..     284     304 .. 0.88
  13 !   11.9   0.0     6e-05      0.18       5      24 .]     309     328 ..     307     328 .. 0.94
  14 !    5.5   0.0    0.0072        21       2      24 .]     330     352 ..     329     352 .. 0.83
  15 !   21.4   0.1   5.7e-08   0.00017       3      23 ..     355     375 ..     353     376 .. 0.89
  16 !    6.5   0.0    0.0033       9.9       5      24 .]     381     400 ..     378     400 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0013
       LRR_6  4 hLteLdLsgNdIg 16
                +Lt+L++ +N+I+
  EFC36336.1  3 NLTYLNIDWNKIS 15
                8**********96 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 9.9e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                LteL++++N + De ++++
  EFC36336.1 47 LTELNVNWNRLKDEDVKSI 65
                9****************98 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0018
       LRR_6  3 thLteLdLsgNdIgDeGaea 22
                 +Lt L+LsgN+I+   ++ 
  EFC36336.1 69 KNLTLLELSGNEISKNSMKF 88
                689**********9887765 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0023
       LRR_6   5 LteLdLsgNdIgDeGa 20 
                 Lt+L++  N I +eG+
  EFC36336.1  95 LTKLSVGLNSIENEGI 110
                 9**************7 PP

  == domain 5  score: 7.4 bits;  conditional E-value: 0.0017
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  ++Lt L++   +I+ eG++ +
  EFC36336.1 116 LSKLTCLNIINANITSEGVKLI 137
                 589****************987 PP

  == domain 6  score: 18.9 bits;  conditional E-value: 3.5e-07
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  ++Lt Ld+sgN Ig eG++ +
  EFC36336.1 140 LSNLTILDISGNLIGAEGGQYI 161
                 589***************9876 PP

  == domain 7  score: -0.9 bits;  conditional E-value: 0.82
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +L+ L  s+N++g  Ga+++
  EFC36336.1 166 NLKILVASDNELGVFGAKSI 185
                 67777779999998888887 PP

  == domain 8  score: 7.9 bits;  conditional E-value: 0.0012
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L L gN Ig+eGa+ ++
  EFC36336.1 191 LTSLCLIGNSIGNEGAKYIS 210
                 88899999********9885 PP

  == domain 9  score: 14.3 bits;  conditional E-value: 1e-05
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                 t Lt LdL  N+Ig+eG 
  EFC36336.1 213 TQLTDLDLGRNEIGNEGF 230
                 77***************5 PP

  == domain 10  score: 7.3 bits;  conditional E-value: 0.0018
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +Lt Ld+ +N+I+D
  EFC36336.1 238 KLTNLDMVSNNISD 251
                 7***********99 PP

  == domain 11  score: 10.8 bits;  conditional E-value: 0.00014
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L  Ld++ N+I D G+  ++
  EFC36336.1 261 LNCLDVRKNKIEDTGIRNIC 280
                 789************99887 PP

  == domain 12  score: 4.4 bits;  conditional E-value: 0.016
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 L +L L gN I+ eGa+
  EFC36336.1 285 LNALRLCGNPITSEGAK 301
                 6789999********97 PP

  == domain 13  score: 11.9 bits;  conditional E-value: 6e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L++s  +I+DeGa+ +a
  EFC36336.1 309 LTNLSISETHIDDEGAKFIA 328
                 99**************9887 PP

  == domain 14  score: 5.5 bits;  conditional E-value: 0.0072
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  t+L++Ld+s   I+  G++ ++
  EFC36336.1 330 LTTLKYLDISTKRITANGVKFIC 352
                 58********8888888888776 PP

  == domain 15  score: 21.4 bits;  conditional E-value: 5.7e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++L +Ld+++N+IgDeG+  +
  EFC36336.1 355 SKLISLDINWNNIGDEGVLYI 375
                 7899*************9877 PP

  == domain 16  score: 6.5 bits;  conditional E-value: 0.0033
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L++L+  +++Ig eGa+ L+
  EFC36336.1 381 LETLNAVYCNIGLEGAKLLS 400
                 88888899*********986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.1   3.7e-05      0.11      24      58 ..       1      35 [.       1      38 [. 0.85
   2 !   24.3   5.9   6.4e-09   1.9e-05       2      60 ..      46     104 ..      45     105 .. 0.95
   3 !   15.0   4.6   5.3e-06     0.016       2      61 .]      94     153 ..      93     153 .. 0.97
   4 !   15.8   3.1     3e-06    0.0089       2      61 .]     118     177 ..     117     177 .. 0.95
   5 !   22.9   1.1   1.7e-08   5.1e-05       1      61 []     141     201 ..     141     201 .. 0.97
   6 !   17.4   4.4   9.1e-07    0.0027       2      61 .]     190     249 ..     189     249 .. 0.97
   7 !   15.5   3.9   3.6e-06     0.011       2      61 .]     214     271 ..     213     271 .. 0.96
   8 !   11.4   0.3   6.7e-05       0.2       3      61 .]     261     319 ..     259     319 .. 0.94
   9 !   14.0   0.1   1.1e-05     0.033       3      57 ..     285     339 ..     283     343 .. 0.93
  10 !   17.3   0.5   9.9e-07     0.003       2      61 .]     308     367 ..     307     367 .. 0.98
  11 !   11.4   0.2   6.9e-05      0.21       2      60 ..     332     390 ..     331     391 .. 0.86
  12 ?   -3.5   0.0       3.1   9.3e+03      47      55 ..     401     409 ..     396     411 .. 0.51

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.7e-05
                -TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8 24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58
                ++nL++L++  N+++  s+  +sg+++L+ L  sg
  EFC36336.1  1 MKNLTYLNIDWNKISEKSKIILSGMKHLKILAASG 35
                68999999999999999999999999999987776 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 6.4e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+L+++ Nrl++ d ++  +l+nL+ L+Ls N+++  s + +s+L+ L++L +  N 
  EFC36336.1  46 QLTELNVNWNRLKDEDVKSIGNLKNLTLLELSGNEISKNSMKFISQLSELTKLSVGLNS 104
                 79***************************************************987665 PP

  == domain 3  score: 15.0 bits;  conditional E-value: 5.3e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++  N++++ +  +  +ls+L+ L++ n ++t+   + +  L++L+ Ld+sgN +
  EFC36336.1  94 ELTKLSVGLNSIENEGINSIINLSKLTCLNIINANITSEGVKLIGKLSNLTILDISGNLI 153
                 79********************************************************87 PP

  == domain 4  score: 15.8 bits;  conditional E-value: 3e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L++ n ++ts + +   +lsnL++Ld+s Nl+     + +  L++L+ L  s+N L
  EFC36336.1 118 KLTCLNIINANITSEGVKLIGKLSNLTILDISGNLIGAEGGQYIGELNNLKILVASDNEL 177
                 79999999*************************************************987 PP

  == domain 5  score: 22.9 bits;  conditional E-value: 1.7e-08
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nLt+Ld+s N + + + +    l+nLk+L  s+N+l ++ ++++  +++L+sL L gN +
  EFC36336.1 141 SNLTILDISGNLIGAEGGQYIGELNNLKILVASDNELGVFGAKSIGEMNQLTSLCLIGNSI 201
                 69******************************************************99976 PP

  == domain 6  score: 17.4 bits;  conditional E-value: 9.1e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL L  N++ + + +  ++l++L+ LdL++N++     + +  L++L+ Ld+ +N++
  EFC36336.1 190 QLTSLCLIGNSIGNEGAKYISQLTQLTDLDLGRNEIGNEGFKLLTKLEKLTNLDMVSNNI 249
                 799***********************************999*****************97 PP

  == domain 7  score: 15.5 bits;  conditional E-value: 3.6e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt LdL +N + + + +  ++l++L+ Ld+ +N+++ ls  ++ +L  L  Ld++ N++
  EFC36336.1 214 QLTDLDLGRNEIGNEGFKLLTKLEKLTNLDMVSNNISDLS--SIGQLGLLNCLDVRKNKI 271
                 79*************************************9..**************9997 PP

  == domain 8  score: 11.4 bits;  conditional E-value: 6.7e-05
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L+ Ld+++N++++ +     +l +L+ L L  N +t+  ++ +s + +L+ L +s +++
  EFC36336.1 261 LNCLDVRKNKIEDTGIRNICQLGGLNALRLCGNPITSEGAKILSEMVQLTNLSISETHI 319
                 556999************************************************99886 PP

  == domain 9  score: 14.0 bits;  conditional E-value: 1.1e-05
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 L+ L L+ N +ts + +  + + +L+ L++s+  ++   ++ +++L+ L++Ld+s
  EFC36336.1 285 LNALRLCGNPITSEGAKILSEMVQLTNLSISETHIDDEGAKFIAQLTTLKYLDIS 339
                 889*************************************************998 PP

  == domain 10  score: 17.3 bits;  conditional E-value: 9.9e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++s +++ + + ++  +l+ Lk+Ld+s  ++t    + + +L++L sLd+++N++
  EFC36336.1 308 QLTNLSISETHIDDEGAKFIAQLTTLKYLDISTKRITANGVKFICQLSKLISLDINWNNI 367
                 69********************************************************97 PP

  == domain 11  score: 11.4 bits;  conditional E-value: 6.9e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +L++Ld+s  r+t+ + ++  +ls+L +Ld++ N++       +s + +L+ L+  +++
  EFC36336.1 332 TLKYLDISTKRITANGVKFICQLSKLISLDINWNNIGDEGVLYISRMQQLETLNAVYCN 390
                 79*********************************988776778888888888877766 PP

  == domain 12  score: -3.5 bits;  conditional E-value: 3.1
                 T--S-.EEE CS
       LRR_8  47 gLpsLrsLd 55 
                  +++L+ Ld
  EFC36336.1 401 EMEQLTVLD 409
                 444455444 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.2    0.0055        16       1      33 [.       2      36 ..       2      46 .. 0.71
   2 !   15.9   4.2   4.4e-06     0.013       2      40 ..      46      82 ..      45      85 .. 0.86
   3 !   10.6   4.5   0.00021      0.62       1      39 [.      69     105 ..      69     118 .. 0.80
   4 ?    4.6   2.4     0.016        47       2      36 ..      94     129 ..      93     132 .. 0.65
   5 !   14.7   3.1   1.1e-05     0.031       2      36 ..     118     153 ..     114     157 .. 0.87
   6 !   11.0   0.1   0.00015      0.45       2      39 ..     166     201 ..     165     213 .. 0.87
   7 !   17.1   5.7   1.9e-06    0.0056       1      41 [.     213     254 ..     213     278 .. 0.89
   8 ?    1.9   0.2      0.11   3.3e+02       5      37 ..     263     296 ..     260     304 .. 0.68
   9 !    8.1   0.1    0.0012       3.7       3      36 ..     285     319 ..     283     334 .. 0.83
  10 !   12.2   0.0   6.5e-05      0.19       2      36 ..     308     343 ..     307     349 .. 0.84
  11 !    9.4   0.3    0.0005       1.5       1      37 [.     331     368 ..     331     376 .. 0.80
  12 !    8.7   0.4   0.00079       2.4       2      30 ..     356     386 ..     355     394 .. 0.81
  13 !    6.9   0.0    0.0029       8.7       1      36 [.     379     412 ..     379     425 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0055
                SS--EEE--.SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLs.nNqltdipl..leklpnLkeLdLsgN 33
                +nL++L++  n ++++ +   l+++++Lk L  sg 
  EFC36336.1  2 KNLTYLNIDwN-KISEKSKiiLSGMKHLKILAASGS 36
                69999999966.999544457778999999855555 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 4.4e-06
                S--EEE--.SS---E-S-..HHH-TT--EEE-.-S-----GG CS
       LRR_4  2 nLevLdLs.nNqltdipl..leklpnLkeLdLsgNnlitdld 40
                +L++L+ + n +l+d +   +++l+nL+ L LsgN     ++
  EFC36336.1 46 QLTELNVNwN-RLKDEDVksIGNLKNLTLLELSGN----EIS 82
                69******77.*******87668************....553 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00021
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-.S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsg.Nnlitdl 39 
                 +nL+ L Ls+N +++ +   +++l  L++L++ g N    ++
  EFC36336.1  69 KNLTLLELSGNEISKNSMkfISQLSELTKLSV-GlN----SI 105
                 79*************999*5446********8.634....33 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.016
                 S--EEE--SS---E-S-HH...H-TT--EEE-..-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplle...klpnLkeLdL.sgNnli 36 
                  L++L+ + N +   ++++   +l +L+ L++ + N  i
  EFC36336.1  94 ELTKLSVGLNSIEN-EGINsiiNLSKLTCLNIiNAN--I 129
                 58999999779994.454433468888888874444..4 PP

  == domain 5  score: 14.7 bits;  conditional E-value: 1.1e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L+ L++ n ++t+ +   ++kl nL+ Ld+sgN li
  EFC36336.1 118 KLTCLNIINANITSEGVklIGKLSNLTILDISGN-LI 153
                 7999999999***988895557***********9.66 PP

  == domain 6  score: 11.0 bits;  conditional E-value: 0.00015
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 nL++L  s+N l  ++   ++ + +L++L L gN    ++
  EFC36336.1 166 NLKILVASDNELGVFGAksIGEMNQLTSLCLIGN----SI 201
                 9*************99985446*******99999....54 PP

  == domain 7  score: 17.1 bits;  conditional E-value: 1.9e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdlde 41 
                 ++L+ LdL+ N +   ++  l kl +L+ Ld+ +N +i+dl++
  EFC36336.1 213 TQLTDLDLGRNEIGNEGFklLTKLEKLTNLDMVSN-NISDLSS 254
                 68************888897779*********666.5888875 PP

  == domain 8  score: 1.9 bits;  conditional E-value: 0.11
                 EEE--SS---E-S-HH..H-TT--EEE-.-S---- CS
       LRR_4   5 vLdLsnNqltdiplle..klpnLkeLdLsgNnlit 37 
                  Ld + N++ d +  +  +l  L  L L gN +it
  EFC36336.1 263 CLDVRKNKIEDTGIRNicQLGGLNALRLCGN-PIT 296
                 5888889999877755334555666667777.554 PP

  == domain 9  score: 8.1 bits;  conditional E-value: 0.0012
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 L  L L +N +t+ +   l+ + +L+ L++s+   i
  EFC36336.1 285 LNALRLCGNPITSEGAkiLSEMVQLTNLSISET-HI 319
                 56699999****999998777*********887.44 PP

  == domain 10  score: 12.2 bits;  conditional E-value: 6.5e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L++s +++ d +   +++l+ Lk+Ld+s   +i
  EFC36336.1 308 QLTNLSISETHIDDEGAkfIAQLTTLKYLDISTK-RI 343
                 79************99996668*********553.44 PP

  == domain 11  score: 9.4 bits;  conditional E-value: 0.0005
                 SS--EEE--.SS---E-S-.HH.H-TT--EEE-..-S---- CS
       LRR_4   1 pnLevLdLs.nNqltdipl.le.klpnLkeLdL.sgNnlit 37 
                 + L++Ld+s   ++t  +  +  +l +L +Ld+ ++N  i+
  EFC36336.1 331 TTLKYLDIStK-RITANGVkFIcQLSKLISLDInWNN--IG 368
                 579******66.9**988895546*********4444..55 PP

  == domain 12  score: 8.7 bits;  conditional E-value: 0.00079
                 S--EEE--.SS---E-S-HH.H.-TT--EEE- CS
       LRR_4   2 nLevLdLs.nNqltdiplle.k.lpnLkeLdL 30 
                 +L++Ld++ n ++ d + l+ + + +L++L+ 
  EFC36336.1 356 KLISLDINwN-NIGDEGVLYiSrMQQLETLNA 386
                 89******76.****99977766*******94 PP

  == domain 13  score: 6.9 bits;  conditional E-value: 0.0029
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 ++Le+L+   +++  +++   l+ + +L++Ld+    +i
  EFC36336.1 379 QQLETLNAVYCNIG-LEGaklLSEMEQLTVLDV----KI 412
                 589******99999.777675556********8....34 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.16   4.8e+02      64     112 ..       2      50 ..       1      52 [. 0.83
   2 !   14.0   4.1   8.7e-06     0.026      41     146 ..      44     147 ..      39     150 .. 0.86
   3 !    8.6   0.0   0.00041       1.2      64     129 ..     141     205 ..     137     224 .. 0.78
   4 !   11.0   0.8   7.4e-05      0.22      41     127 ..     236     321 ..     224     343 .. 0.83
   5 ?    3.9   0.1     0.011        33      63     148 ..     330     411 ..     318     426 .. 0.67

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.16
       LRR_9  64 krlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlasl 112
                 k l  l ++ n+i   ++ +   + +l+ l  +++e+++++ ld l++l
  EFC36336.1   2 KNLTYLNIDWNKISEKSKIILSGMKHLKILAASGSEIDKFSRLDQLTEL 50 
                 6778888888999998888888999999999999999999999999887 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 8.7e-06
       LRR_9  41 ldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviy 137
                 ldq+  ++++ n +++  + ++  lk l  l l+ n i + + ++   l +l++l +  n++++   ++ +++l+kl++l ++++ +t++      +i 
  EFC36336.1  44 LDQLTELNVNWNRLKDedVKSIGNLKNLTLLELSGNEISKNSMKFISQLSELTKLSVGLNSIENE-GINSIINLSKLTCLNIINANITSEG---VKLIG 138
                 7899999999888875225678889*************************************885.58***************99988764...57888 PP

       LRR_9 138 klkqlrlld 146
                 kl +l++ld
  EFC36336.1 139 KLSNLTILD 147
                 999988888 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00041
       LRR_9  64 krlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                   l +l ++ n i   + +    l nl+ lv ++nel  ++  + + ++++l++l+l+ n++ n+ 
  EFC36336.1 141 SNLTILDISGNLIGAEGGQYIGELNNLKILVASDNELGVFGA-KSIGEMNQLTSLCLIGNSIGNEG 205
                 55677777777777777777778999************9998.99****************98864 PP

  == domain 4  score: 11.0 bits;  conditional E-value: 7.4e-05
       LRR_9  41 ldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 l+++  +d+  n+i +l ++  l  l++l + +n+i  ++      l  l++l l +n +++ +  + l ++ +l++ls+ ++ + +
  EFC36336.1 236 LEKLTNLDMVSNNISDLSSIGQLGLLNCLDVRKNKIEDTGIRNICQLGGLNALRLCGNPITSEGA-KILSEMVQLTNLSISETHIDD 321
                 6777889******************************99988888899************99887.899**********98776543 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.011
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldfr 148
                 l  lk l ++  ri+  +    +++ +l++l+  + + ++++d + +  +++++ l  l++  +n       ++  ++ql++ld +
  EFC36336.1 330 LTTLKYLDISTKRITANG---VKFICQLSKLISLDINWNNIGD-EGVLYISRMQQLETLNAVYCNIGLEGAKLLSEMEQLTVLDVK 411
                 455666666666665443...4556666666666666666666.666667777777777777777777777888888888888864 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.1    0.0055        17       1      13 [.       3      15 ..       3      31 .. 0.82
   2 !    7.3   0.1     0.003       8.9       1      23 []      46      68 ..      46      68 .. 0.86
   3 ?    2.2   1.4      0.14   4.2e+02       1      12 [.      70      81 ..      70     116 .. 0.71
   4 ?    5.2   0.0     0.014        42       1      12 [.     142     153 ..     142     165 .. 0.84
   5 ?    1.0   0.0      0.35   1.1e+03       1      21 [.     166     186 ..     166     188 .. 0.87
   6 ?   -0.5   0.0       1.1   3.3e+03       2      20 ..     191     209 ..     190     212 .. 0.74
   7 ?    0.5   2.7       0.5   1.5e+03       1       6 [.     238     243 ..     214     282 .. 0.65
   8 ?    0.8   0.0       0.4   1.2e+03       4      18 ..     287     301 ..     284     316 .. 0.76
   9 ?   -0.5   0.0       1.1   3.2e+03       2       8 ..     333     339 ..     332     346 .. 0.88
  10 !    6.9   0.0     0.004        12       1      16 [.     356     371 ..     356     378 .. 0.80
  11 ?   -0.3   0.0      0.95   2.8e+03       2      12 ..     381     391 ..     380     411 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0055
       LRR_1  1 nLrhLdLsnnpll 13
                nL++L++ +n ++
  EFC36336.1  3 NLTYLNIDWNKIS 15
                8*********984 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.003
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                +L++L++++n+l +    s+ nL
  EFC36336.1 46 QLTELNVNWNRLKDEDVKSIGNL 68
                599*********98888888776 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.14
       LRR_1  1 nLrhLdLsnnpl 12
                nL+ L Ls+n +
  EFC36336.1 70 NLTLLELSGNEI 81
                799999999987 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+ Ld+s+n +
  EFC36336.1 142 NLTILDISGNLI 153
                 8*********87 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.35
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL+ L  s+n l+ +++ s+ 
  EFC36336.1 166 NLKILVASDNELGVFGAKSIG 186
                 89***99*****999988875 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L++L L +n++++ ++ ++
  EFC36336.1 191 LTSLCLIGNSIGNEGAKYI 209
                 8999999999877666655 PP

  == domain 7  score: 0.5 bits;  conditional E-value: 0.5
       LRR_1   1 nLrhLd 6  
                 +L+ Ld
  EFC36336.1 238 KLTNLD 243
                 334444 PP

  == domain 8  score: 0.8 bits;  conditional E-value: 0.4
       LRR_1   4 hLdLsnnpllglppn 18 
                  L L++np+++ ++ 
  EFC36336.1 287 ALRLCGNPITSEGAK 301
                 5899****9766655 PP

  == domain 9  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1   2 LrhLdLs 8  
                 L++Ld+s
  EFC36336.1 333 LKYLDIS 339
                 9****97 PP

  == domain 10  score: 6.9 bits;  conditional E-value: 0.004
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L +Ld+++n++++ +
  EFC36336.1 356 KLISLDINWNNIGDEG 371
                 799********97655 PP

  == domain 11  score: -0.3 bits;  conditional E-value: 0.95
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L+  ++++
  EFC36336.1 381 LETLNAVYCNI 391
                 99999888887 PP

>> Ribosomal_L12_N  Ribosomal protein L7/L12 dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.1    0.0059        18       8      18 ..      67      77 ..      64      78 .. 0.89
   2 ?   -2.8   0.0       1.8   5.4e+03       5      13 ..      88      96 ..      87      97 .. 0.78
   3 ?    1.8   0.0     0.067     2e+02       5      18 ..     136     149 ..     134     150 .. 0.87
   4 ?    2.2   0.3      0.05   1.5e+02       4      18 ..     397     411 ..     396     412 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0059
                     HHHTSBHHHHH CS
  Ribosomal_L12_N  8 aikeltvLEls 18
                      +k+lt+LEls
       EFC36336.1 67 NLKNLTLLELS 77
                     69********8 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.8
                     HHHHHHTSB CS
  Ribosomal_L12_N  5 iieaikelt 13
                     +i +++elt
       EFC36336.1 88 FISQLSELT 96
                     688888887 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.067
                      HHHHHHTSBHHHHH CS
  Ribosomal_L12_N   5 iieaikeltvLEls 18 
                      +i  +++lt+L++s
       EFC36336.1 136 LIGKLSNLTILDIS 149
                      7889*******987 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.05
                      HHHHHHHTSBHHHHH CS
  Ribosomal_L12_N   4 eiieaikeltvLEls 18 
                      +++ + ++ltvL+++
       EFC36336.1 397 KLLSEMEQLTVLDVK 411
                      68999*******985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       363  (0.0202465); expected 358.6 (0.02)
Passed bias filter:                      222  (0.0123822); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 2743.00
//
Query:       EFC36337.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-09   38.0   9.1      2e-09   37.2   9.1    1.4  1  zf-A20    A20-like zinc finger


Domain annotation for each model (and alignments):
>> zf-A20  A20-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.2   9.1   1.1e-13     2e-09       1      24 []       2      25 ..       2      25 .. 0.97

  Alignments for each domain:
  == domain 1  score: 37.2 bits;  conditional E-value: 1.1e-13
      zf-A20  1 llCrngCGFyGnpatnglCSkCYk 24
                +lC+ +CGFyGn +++g+CS CY+
  EFC36337.1  2 SLCKDNCGFYGNDNYEGYCSTCYR 25
                69*********************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       741  (0.0413297); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 967.86
//
Query:       EFC36338.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.4e-14   54.1   0.0    2.1e-14   53.5   0.0    1.2  1  SBP_bac_3  Bacterial extracellular solute-binding proteins, f


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.5   0.0   1.2e-18   2.1e-14      36     165 ..      96     230 ..      86     242 .. 0.87

  Alignments for each domain:
  == domain 1  score: 53.5 bits;  conditional E-value: 1.2e-18
                 CT-EEEEEE.....-.SGGGHHHHHHTTSSSEEESSEB--HHHHTTEEEESESEEEEEEEEEEETTSHGTCCHSSCGCGTTS..EEEEETTSHHHHHHH CS
                 xxxxxxxxx.....x.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxx RF
   SBP_bac_3  36 lgvkvefvp.....v.swdelipalksgkvDiaiaaititpeReekvdFsqpyfsagqvllvrkkdaskissiksladLkgk..kvgvqagstaeellk 126
                 +++kve+++        ++++ ++++sg +D++ +++t t+eR+++  F  +y +++q++l   +  +  ++++sl+dL+++   vg+ ag+t+e+l+k
  EFC36338.1  96 INLKVEYRYlntskLgFFATMRQGVDSGYCDMISSNTTPTDERKKVSHFQCSYGTTAQGFLRS-G-LEPERKLSSLNDLNQTgiIVGAYAGTTYETLVK 192
                 556666666667775589*******************************************88.4.45678999999**77655899********9999 PP

                 HHHHCTSEEEEESSHHHHHHHHHTTSSSEEEEEHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 127 eelkkgaeivefdtleealqaLkngrvdavvadspvlay 165
                  +l   a+ v+f+  ++ +q +++++v a+++d + l+ 
  EFC36338.1 193 TKLS-AATYVPFYEVNNQYQSINAKSVHALIGDGTDLQI 230
                 8665.9999************************988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       456  (0.0254337); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1646.17
//
Query:       EFC36339.1  [L=475]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-43  144.4  17.6    1.4e-15   56.7   0.0    7.1  8  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.1   0.00052       9.4      30      48 ..     167     185 ..     149     189 .. 0.67
   2 !   14.2   0.3   1.5e-06     0.027       4      46 ..     191     233 ..     165     234 .. 0.73
   3 !   23.6   0.5   1.7e-09   3.1e-05       2      44 ..     241     284 ..     240     289 .. 0.88
   4 !   12.7   0.6   4.6e-06     0.082      14      47 ..     279     312 ..     271     315 .. 0.87
   5 !   30.6   0.7   1.1e-11     2e-07       1      48 [.     290     339 ..     290     340 .. 0.86
   6 ?   -2.3   0.1      0.22   3.9e+03      23      41 ..     366     384 ..     360     387 .. 0.66
   7 !   56.7   0.0   7.7e-20   1.4e-15       1      49 []     392     440 ..     392     440 .. 0.99
   8 !   19.6   0.0     3e-08   0.00054       2      27 ..     443     468 ..     442     471 .. 0.94

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.00052
     DUF4116  30 vlkAvkqngtalsyaseeL 48 
                  + A++ +++++ y+++ +
  EFC36339.1 167 TMHAIELDPKCYAYVPDYI 185
                 4667777777777777665 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 1.5e-06
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 i+++++ +n+s  + +++eL  D ++v+   k++ ++l yas+
  EFC36339.1 191 IAKKVFIRNPSLGTLIPKELLEDTDFVMDVYKSSQSILFYASP 233
                 4444444555544557777777999999999999999999997 PP

  == domain 3  score: 23.6 bits;  conditional E-value: 1.7e-09
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqng.talsya 44 
                 r ++ ea+k++ + ++++see++ D+ei+  ++ ++  +++ y+
  EFC36339.1 241 RVFMIEALKSDVCLIRNCSEEIRTDREIIDMIIDIDAaSSFQYI 284
                 559**************************999988887777777 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 4.6e-06
     DUF4116  14 salkylseeLknDkeivlkA.vkqngtalsyasee 47 
                 s+++y+  ++k D +iv+kA  k+n t+l y+  +
  EFC36339.1 279 SSFQYIG-KFKEDEDIVKKAlFKSNFTILHYINSD 312
                 6899999.9**********98899999**999766 PP

  == domain 5  score: 30.6 bits;  conditional E-value: 1.1e-11
     DUF4116   1 DrEivleavkkngs.alkyl.seeLknDkeivlkAvkqngtalsyaseeL 48 
                 D++iv++a+ k ++ +l+y+ s+ L n++e+vl ++k+ng+ ++ ++e +
  EFC36339.1 290 DEDIVKKALFKSNFtILHYInSDFLLNNRELVLTILKSNGKYINEMPEAI 339
                 9*******6665555*****66779******************9999865 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 0.22
     DUF4116  23 LknDkeivlkAvkqngtal 41 
                 + +D+e  + +++ n++ l
  EFC36339.1 366 IESDREDFKSILQFNPDLL 384
                 5677777777777776655 PP

  == domain 7  score: 56.7 bits;  conditional E-value: 7.7e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+ +ea++++g++l+++see+k Dke+vl Av +ng+al yas++L+
  EFC36339.1 392 DRELLKEALSHCGFCLRFASEEFKADKELVLTAVTKNGSALMYASPKLK 440
                 9*********************************************997 PP

  == domain 8  score: 19.6 bits;  conditional E-value: 3e-08
     DUF4116   2 rEivleavkkngsalkylseeLknDk 27 
                 +Eivl av+++g+a++++s++++n k
  EFC36339.1 443 EEIVLAAVTNDGKAIRFASKRFSNQK 468
                 8**********************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.50
# Mc/sec: 2855.03
//
Query:       EFC36340.1  [L=541]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (541 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1431  (0.0798148); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 3706.33
//
Query:       EFC36341.1  [L=2641]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-32  110.1 189.4    9.1e-05   22.7  10.6   13.0 12  EGF_2     EGF-like domain
    0.00013   22.2 138.0      0.023   15.0   4.2   12.9 12  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   9.5   1.8e-06     0.016       6      32 .]      25      50 ..      16      50 .. 0.85
   2 !   19.1   7.1   1.4e-07    0.0012       7      32 .]      70      94 ..      68      94 .. 0.94
   3 !   22.7  10.6     1e-08   9.1e-05       6      32 .]     323     348 ..     319     348 .. 0.91
   4 !    7.6   6.5   0.00055         5       6      29 ..     364     386 ..     360     389 .. 0.81
   5 !   20.1   9.5   6.8e-08   0.00061       5      32 .]     401     427 ..     398     427 .. 0.86
   6 !   18.0  11.0   3.1e-07    0.0028       6      32 .]     652     677 ..     648     677 .. 0.87
   7 !    9.4   8.8   0.00015       1.4       6      32 .]     693     718 ..     684     718 .. 0.85
   8 !   10.6   4.9   6.4e-05      0.57       6      32 .]     735     761 ..     730     761 .. 0.82
   9 !   17.7  10.0   3.8e-07    0.0034       7      32 .]     779     803 ..     776     803 .. 0.93
  10 !   13.5   7.7   8.1e-06     0.073       5      32 .]     817     843 ..     812     843 .. 0.90
  11 !   11.9  12.3   2.4e-05      0.22       6      32 .]    1457    1487 ..    1453    1487 .. 0.71
  12 !   12.8   3.7   1.3e-05      0.12       8      32 .]    2173    2194 ..    2167    2194 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.8e-06
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                + C+ghGtCv+ + +C+C  +y+G  C
  EFC36341.1 25 NVCSGHGTCVSDN-RCQCHENYHGYVC 50
                68********777.*********9666 PP

  == domain 2  score: 19.1 bits;  conditional E-value: 1.4e-07
       EGF_2  7 iCgghGtCvnqcGqCdCdsgyqGktC 32
                 C+ghG C +++ +C+C+ g++G++C
  EFC36341.1 70 VCSGHGACMSFN-NCSCEIGWYGDKC 94
                5*******9999.8************ PP

  == domain 3  score: 22.7 bits;  conditional E-value: 1e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghG+C+ q  qC+C++gy+G  C
  EFC36341.1 323 TVCNGHGKCIGQD-QCQCNNGYSGIEC 348
                 67********888.9***********9 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.00055
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqG 29 
                 ++Cgg+G+C++q   C Cd+  q+
  EFC36341.1 364 DACGGGGHCISQD-TCLCDNVVQQ 386
                 47********999.9***986655 PP

  == domain 5  score: 20.1 bits;  conditional E-value: 6.8e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ghG C + + +C+C+ g++G++C
  EFC36341.1 401 SQVCSGHGACLSNN-NCSCEIGWYGDKC 427
                 578*******8555.8************ PP

  == domain 6  score: 18.0 bits;  conditional E-value: 3.1e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G+C +    C+C+sgy+G++C
  EFC36341.1 652 AVCSGNGKCLSDD-HCQCNSGYSGNYC 677
                 57*******8666.7************ PP

  == domain 7  score: 9.4 bits;  conditional E-value: 0.00015
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ hGtCv++  +C+C+ gy+  +C
  EFC36341.1 693 GVCSDHGTCVSSD-NCVCELGYYFEDC 718
                 57********899.8******996666 PP

  == domain 8  score: 10.6 bits;  conditional E-value: 6.4e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyq.GktC 32 
                 + C ghG Cvn    C+Cds yq  ++C
  EFC36341.1 735 SVCYGHGRCVNWD-TCVCDSPYQnSAYC 761
                 67********777.9****999966776 PP

  == domain 9  score: 17.7 bits;  conditional E-value: 3.8e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ghG+C ++  qC+C+s+y G +C
  EFC36341.1 779 VCSGHGQCTDSD-QCVCNSNYDGSSC 803
                 6*******9888.************* PP

  == domain 10  score: 13.5 bits;  conditional E-value: 8.1e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG+C +++  C C+ g++  +C
  EFC36341.1 817 SLVCNGHGVCGSFN-TCTCSIGWTSSYC 843
                 678*******9899.9***********9 PP

  == domain 11  score: 11.9 bits;  conditional E-value: 2.4e-05
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyq.....GktC 32  
                   +C++hG C+ ++GqC C+s+y      G +C
  EFC36341.1 1457 INCSNHGDCN-SEGQCLCSSNYEegfwsGTKC 1487
                  46*******9.679****88875433336666 PP

  == domain 12  score: 12.8 bits;  conditional E-value: 1.3e-05
       EGF_2    8 CgghGtCvnqcGqCdCdsgyqGktC 32  
                  C+ +G+ v   G+C+C +g+ Gk+C
  EFC36341.1 2173 CQ-NGVDV--AGECKCRDGWIGKHC 2194
                  54.35555..569************ PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   6.2   8.6e-05      0.77       3      30 ..      24      47 ..      21      47 .. 0.86
   2 !    7.7   2.2   0.00051       4.6       5      31 ..      68      92 ..      65      93 .. 0.87
   3 !    9.8   6.2   0.00011      0.95       6      31 ..     325     346 ..     320     347 .. 0.87
   4 ?   -3.6   9.1       1.7   1.5e+04       3      25 ..     361     381 ..     355     382 .. 0.79
   5 !    8.2   3.0   0.00033         3       5      31 ..     403     425 ..     398     426 .. 0.86
   6 !   15.0   4.2   2.6e-06     0.023       6      32 .]     654     676 ..     647     676 .. 0.84
   7 !   10.0   3.0   9.1e-05      0.81       6      29 ..     695     714 ..     690     717 .. 0.87
   8 !    4.0   5.6    0.0073        65       4      29 ..     733     756 ..     726     758 .. 0.83
   9 !   10.6   2.8   6.2e-05      0.56       4      31 ..     776     801 ..     773     802 .. 0.88
  10 !    5.3   3.4    0.0028        25       6      29 ..     820     839 ..     812     842 .. 0.81
  11 ?    3.5   7.3      0.01        91       5      28 ..    1458    1477 ..    1453    1484 .. 0.82
  12 !    7.4   0.4   0.00063       5.6      11      32 .]    2172    2193 ..    2170    2193 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 8.6e-05
                STTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF  3 pnpCsngGtCvdtgrggytCiCpeGytG 30
                pn Cs++GtCv+      +C+C e y+G
  EFC36341.1 24 PNVCSGHGTCVSDN----RCQCHENYHG 47
                455*******8888....9*******98 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00051
                T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF  5 p..CsngGtCvdtgrggytCiCpeGytGk 31
                p  Cs++G C++      +C C +G+ G+
  EFC36341.1 68 PfvCSGHGACMSFN----NCSCEIGWYGD 92
                555*******8888....********997 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00011
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+++G+C     g  +C+C +Gy+G+
  EFC36341.1 325 CNGHGKC----IGQDQCQCNNGYSGI 346
                 *******....68999********96 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 1.7
                 STT..STTT-EEEEETTTEEEEEEC CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCp 25 
                 ++p  C +gG C++      tC C+
  EFC36341.1 361 DHPdaCGGGGHCISQD----TCLCD 381
                 36699*******7777....99996 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.00033
                 TSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 pCsngGtCvdtgrggytCiCpeGytGk 31 
                  Cs++G C+++     +C C +G+ G+
  EFC36341.1 403 VCSGHGACLSNN----NCSCEIGWYGD 425
                 4*******8888....********997 PP

  == domain 6  score: 15.0 bits;  conditional E-value: 2.6e-06
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs++G+C++      +C+C +Gy+G++
  EFC36341.1 654 CSGNGKCLSDD----HCQCNSGYSGNY 676
                 *******5555....**********86 PP

  == domain 7  score: 10.0 bits;  conditional E-value: 9.1e-05
                 STTT-EEEEETTTEEEEEECTTEE CS
         EGF   6 CsngGtCvdtgrggytCiCpeGyt 29 
                 Cs +GtCv++     +C C  Gy 
  EFC36341.1 695 CSDHGTCVSSD----NCVCELGYY 714
                 *******9999....*******96 PP

  == domain 8  score: 4.0 bits;  conditional E-value: 0.0073
                 TT..STTT-EEEEETTTEEEEEECTTEE CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGyt 29 
                 +p  C ++G+Cv+      tC C+++y+
  EFC36341.1 733 DPsvCYGHGRCVNWD----TCVCDSPYQ 756
                 5699*******9999....******997 PP

  == domain 9  score: 10.6 bits;  conditional E-value: 6.2e-05
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +p  Cs++G C d+     +C C + y+G+
  EFC36341.1 776 DPkvCSGHGQCTDSD----QCVCNSNYDGS 801
                 5777*******7777....*********96 PP

  == domain 10  score: 5.3 bits;  conditional E-value: 0.0028
                 STTT-EEEEETTTEEEEEECTTEE CS
         EGF   6 CsngGtCvdtgrggytCiCpeGyt 29 
                 C+++G C    +   tC+C++G+t
  EFC36341.1 820 CNGHGVC----GSFNTCTCSIGWT 839
                 *******....4777*******98 PP

  == domain 11  score: 3.5 bits;  conditional E-value: 0.01
                  TSTTT-EEEEETTTEEEEEECTTE CS
         EGF    5 pCsngGtCvdtgrggytCiCpeGy 28  
                  +Csn+G C    + + +C C++ y
  EFC36341.1 1458 NCSNHGDC----NSEGQCLCSSNY 1477
                  5*******....5556*****998 PP

  == domain 12  score: 7.4 bits;  conditional E-value: 0.00063
                  EEEEETTTEEEEEECTTEESTT CS
         EGF   11 tCvdtgrggytCiCpeGytGkr 32  
                  tC ++ +   +C+C  G+ Gk+
  EFC36341.1 2172 TCQNGVDVAGECKCRDGWIGKH 2193
                  798888999***********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2641 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2120  (0.118244); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.58u 0.35s 00:00:01.93 Elapsed: 00:00:00.60
# Mc/sec: 13295.76
//
Query:       EFC36342.1  [L=685]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-15   55.5   0.1    1.4e-14   54.2   0.1    1.7  1  C2        C2 domain
    1.7e-14   53.7   0.4    1.4e-13   50.6   1.1    1.8  2  PhoD      PhoD-like phosphatase


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.2   0.1   1.5e-18   1.4e-14       2     103 .]       6     131 ..       5     131 .. 0.91

  Alignments for each domain:
  == domain 1  score: 54.2 bits;  conditional E-value: 1.5e-18
                 EEEEEEEEEESSSSSSTTSSCEEEEEEEE..............ECEEEEEE-SCSSSSSSEEEEEEEEEESC.........HTTSEEEEEEEEECSSST CS
          C2   2 klevtvieAknLpnkdkkgssdpyvkvsl..............dgkqkakTrviknslnPvWnekftfevae.........leeakLeveVfdndrlsk 77 
                 +l+v++i++++Lp+ d  gs+d+yv+v++              +++ +++Tr + +slnP++ne+f+f+ ++         + ++ L v+V d++ + k
  EFC36342.1   6 SLKVSIIKCTDLPKVDLLGSCDAYVQVWVahsdpnkfkqaqtdNEEGIKQTR-VITSLNPEFNEQFQFKFPQvnsgmekkdPMDKYLVVRVVDKNAILK 103
                 799************************************9999999999***.67778**********9999999************************ PP

                 EEEEEEEEEEGHH..HHTTHHHHEEEEH CS
          C2  78 ddfiGkveiplst..llsgeeaegwypl 103
                 d++iG v i++    l+ g++ +++ypl
  EFC36342.1 104 DEVIGFVMIQFFGlnLKVGKPLRRTYPL 131
                 *********9776566777777777765 PP

>> PhoD  PhoD-like phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.6   1.1   1.5e-17   1.4e-13       4     172 ..     311     486 ..     308     510 .. 0.72
   2 ?   -0.4   0.0     0.049   4.4e+02     253     280 ..     570     598 ..     561     618 .. 0.68

  Alignments for each domain:
  == domain 1  score: 50.6 bits;  conditional E-value: 1.5e-17
        PhoD   4 vSCqnye..agyfnayrelaee.edlDlvlhlGDyiYey.gpgeyase.aaelgrevepp.keivtladYReryaqyktdadlqaahaaapfivvwDDH 96 
                 vSC+  e  +    +++++ e+ ++ D++lh+GD iY++ g++ ++ + +    r+++ + +e +  +++R+ y+ +      +++ ++++ ++++DDH
  EFC36342.1 311 VSCNFIErrEPGKDTWERMLEQiDNTDVLLHMGDQIYADyGHNAFDEAvKICNSRNKVSNeEEELIKEEFRKYYRFNWNHIATRKVLSQVSNLMILDDH 409
                 78855543356678999**99956**************94455555544444445554446788899******************************** PP

        PhoD  97 EvaNnswsggaenhqeetegdf.ekrkaaAlqAyfEwmPireakpgeeeriyrsfe.....yGdladlflLDtRqyrrdqav 172
                 E++++ w ++ + ++   +g++     + A+  y E++   + + +++e+i+++ e     +Gd   +++LD+R  r+  + 
  EFC36342.1 410 EIRDD-WGSNPSDQT---QGSIpYYVGSLAREVYWEYQRSLRGDVSNKEEIFKKHEayyniIGD-TGIVVLDLRASRSFLEH 486
                 *****.988544444...56662466789********754444456666675554322222577.78999999988886665 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.049
        PhoD 253 lletikeak.irnvVvLtGDvHaawandl 280
                 l++ +kea+  rn  +L+GDvH    + +
  EFC36342.1 570 LMKKWKEADsKRNGLFLGGDVHIGGSTSI 598
                 55555444313899********8777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (685 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       457  (0.0254894); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 3988.65
//
Query:       EFC36343.1  [L=121]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (121 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.29s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 822.01
//
Query:       EFC36344.1  [L=170]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1045  (0.0582855); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1139.10
//
Query:       EFC36345.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1234  (0.068827); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.50
# Mc/sec: 1351.64
//
Query:       EFC36346.1  [L=305]
Description: hypothetical protein NAEGRDRAFT_54432 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.57
# Mc/sec: 1600.43
//
Query:       EFC36347.1  [L=411]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-19   67.8  11.8    3.7e-06   26.6   0.0    6.0  6  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    9.7e-13   48.5   9.5    2.6e-08   34.4   0.2    3.7  3  RCC1      Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0       0.1   9.1e+02      12      21 ..      60      69 ..      54      75 .. 0.87
   2 ?   -0.8   0.0      0.16   1.5e+03      13      22 ..     120     129 ..     119     129 .. 0.88
   3 !   21.4   0.4   1.7e-08   0.00015       6      30 .]     152     176 ..     148     176 .. 0.94
   4 !   12.3   0.0   1.3e-05      0.12       9      29 ..     205     225 ..     194     226 .. 0.87
   5 !   26.6   0.0   4.1e-10   3.7e-06       1      30 []     252     281 ..     252     281 .. 0.98
   6 !    7.1   2.8   0.00054       4.8       2      28 ..     304     330 ..     303     332 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.1
      RCC1_2 12 caLtedGeVl 21
                ++L+ +G+Vl
  EFC36347.1 60 IFLMKSGKVL 69
                68******97 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.16
      RCC1_2  13 aLtedGeVlc 22 
                 a++e+G++++
  EFC36347.1 120 AVMESGRLFS 129
                 78*****986 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 1.7e-08
      RCC1_2   6 aGdyHscaLtedGeVlcWGsNsdGQ 30 
                  G +H +a+t++ eV+++Gs+ +G+
  EFC36347.1 152 TGLSHMMAITNNHEVYGTGSDAYGC 176
                 79**********************8 PP

  == domain 4  score: 12.3 bits;  conditional E-value: 1.3e-05
      RCC1_2   9 yHscaLtedGeVlcWGsNsdG 29 
                 y ++++t++G++l++G+  + 
  EFC36347.1 205 YRTLVVTANGKLLTTGWGVYS 225
                 77**************98765 PP

  == domain 5  score: 26.6 bits;  conditional E-value: 4.1e-10
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V++++ G+ H+++Lt + +V+++G Ns+GQ
  EFC36347.1 252 VIKLALGALHTIVLTKSRKVYGFGFNSYGQ 281
                 8999*************************9 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.00054
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsd 28 
                 +++ +G+ H+++ +++G  +c GsN++
  EFC36347.1 304 VDIWCGWHHTLFESSTGSFYCSGSNGS 330
                 66779********************85 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.0   1.0    0.0086        77       2      16 ..     164     178 ..     163     188 .. 0.89
   2 !   14.0   0.1   6.6e-06     0.059       1      50 []     213     265 ..     213     265 .. 0.87
   3 !   34.4   0.2   2.9e-12   2.6e-08       4      49 ..     271     315 ..     270     315 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.0086
                 TEEEEEE--GGGTTS CS
        RCC1   2 GrVysWGrndyGqLG 16 
                  +Vy+ G++ yG+LG
  EFC36347.1 164 HEVYGTGSDAYGCLG 178
                 58************9 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 6.6e-06
                 TTEEEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS....-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt.esvlvPtkveglsgn....rvvkvacGddhtval 50 
                 +G++++ G++ y q Glg++  ++  P+ v+  + n    +v+k a G+ ht++l
  EFC36347.1 213 NGKLLTTGWGVYSQQGLGNSsGDN--PRFVRHQPMNdlgeHVIKLALGALHTIVL 265
                 699*****************9999..99995555555678************986 PP

  == domain 3  score: 34.4 bits;  conditional E-value: 2.9e-12
                 EEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   4 VysWGrndyGqLGlgtt.esvlvPtkveglsgnrvvkvacGddhtva 49 
                 Vy++G+n+yGqL +g    +   P+++e+++  ++v++ cG++ht++
  EFC36347.1 271 VYGFGFNSYGQLSQGEVtSDFGFPVLIETPQ--PIVDIWCGWHHTLF 315
                 9****************666699*******9..************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (411 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       392  (0.021864); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 2402.21
//
Query:       EFC36348.1  [L=309]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1905  (0.106252); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 2065.05
//
Query:       EFC36349.1  [L=611]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-31  110.1  20.3    2.4e-28   99.1  18.0    2.3  2  MFS_1         Major Facilitator Superfamily
      2e-06   26.9  11.4      2e-06   26.9  11.4    2.8  3  Sugar_tr      Sugar (and other) transporter
    3.7e-06   26.0  18.7     0.0059   15.5   4.3    3.1  3  MFS_1_like    MFS_1 like family
    2.2e-05   23.7   0.1    0.00039   19.6   0.0    2.6  3  CLN3          CLN3 protein
    0.00097   18.5   0.1      0.035   13.4   0.0    2.4  2  MFS_4         Uncharacterised MFS-type transporter YbfB
     0.0047   15.4   1.3      0.033   12.6   0.0    2.2  2  MFS_3         Transmembrane secretion effector
  ------ inclusion threshold ------
      0.076   13.6   0.7      0.076   13.6   0.7    3.3  4  OAD_gamma     Oxaloacetate decarboxylase, gamma chain
       0.64    8.6   6.1        1.2    7.7   5.5    1.6  2  THOC2_N       THO complex subunit 2 N-terminus


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.1  18.0   1.1e-31   2.4e-28       1     353 []     112     550 ..     112     550 .. 0.77
   2 !   22.7   0.6   1.8e-08   4.1e-05     100     187 ..     512     605 ..     494     611 .] 0.81

  Alignments for each domain:
  == domain 1  score: 99.1 bits;  conditional E-value: 1.1e-31
       MFS_1   1 lllaaflsalarsilgpalplalaedlgispse......igllltlyalgaavaslplGrlsdrfGrrrvlllglllfalglllllfasslw.lllvlr 92 
                 +++++++ +l+++ l+p ++ ++  d++++         +gl++++y+l ++++s+++G +sd +Grr+vll+g ++ +l++l++ f s +  + +++r
  EFC36349.1 112 VFFLYLCDSLTFTSLMPYIT-FMIADFNLTDNPteygyyVGLVAAAYFLSQFISSFFWGTISDSIGRRPVLLFGTFFGGLCGLMFGF-SRWLwWACICR 208
                 699*****************.999**9966555568888999***************************************888889.89888****** PP

       MFS_1  93 vlqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggllasslg.....................Wravfyilaivsllafvlfll 170
                 ++ Gl   + + ++ +++ +++  ++++ra++l s++f+l+++lgpllgg+++  +                      + ++ +++  +sl++fvl++l
  EFC36349.1 209 FMFGLL-NGNLGVVKSYLGEITDSTNQARAFSLTSITFGLSSVLGPLLGGVFSRPYQqypsfvmlfpewiqnfviqfpYILPSFFISSFSLVGFVLGYL 306
                 ******.58889999**************************************66668**********9999999977666688899999999999999 PP

       MFS_1 171 llpeepperkrkspkeee..............................................kgtgpaplvpawkallkdpvlw......illiall 217
                  l e +++++  ++   +                                               +         + +++k+  +        +l+ ll
  EFC36349.1 307 KLEEANKNSWYYRKFIAKeseeiadkhkskgstisktnllstptddleeqdqepiviketllqkLKN-------KFDSFRKHEMVAspvpltTCLLYLL 398
                 9977777777777777777777777777788999999999999999987666666664444332222.......2333333332212222234444444 PP

       MFS_1 218 lfffgfsg.....lltllplylqevlglsglllaglllallalvgailallagrls.drlgr....rrrlllallllllaalglallavt.ssavllll 305
                 l++  +++     l++ lp   +  lg+s  + +gl+ ++l++++++ +l+++ ++  ++++    r+ +l+  ++  +++  +++l +t +++++ ++
  EFC36349.1 399 LGSKQIMFdeclpLFAVLPKD-KGGLGMS-SYHLGLMGGFLGFIIFVNQLFITPVViAKFSPltcyRWSILVDTIFN-VIFPEIIWLVATeDDPMWKHV 494
                 444344447889999999995.9999999.577777777777777777777777776**999555333333333333.334444444444666666666 PP

       MFS_1 306 ........vlvliGfglgfvfpsllalasdlappeeagtasglfntagslggalgp 353
                         +l++  +  g  f   + ++++++++++ g+++g ++++ +l+++++p
  EFC36349.1 495 lfwsvlglILLVRQVSNGYSFLGTFLITNNSVSRKNYGKLNGTAQSFVALSRMVSP 550
                 6666666444446668888899999999999999999***************9987 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 1.8e-08
       MFS_1 100 galfpagaaliadwfpkeergraigllsagfslGailgpllggllasslg.........Wravfyilaivsllafvlfllllpeepperkrkspkee 187
                 g +f +   ++   +++++ g+ +g ++++++l+ ++ p++gg +  +++          r vfy+++++s+++f l   l++ ++ ++++++ k +
  EFC36349.1 512 GYSFLGTFLITNNSVSRKNYGKLNGTAQSFVALSRMVSPIIGGSIF-AGSvavskfpidHRMVFYVITVISAVMFFL--SLILNKAINKPKEEAKAD 605
                 667778888999999****************************888.3345699999*****************665..888777777777776666 PP

>> Sugar_tr  Sugar (and other) transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.6      0.43   9.6e+02     211     244 ..      68     108 ..      59     134 .. 0.50
   2 !   26.9  11.4   9.1e-10     2e-06      31     159 ..     136     261 ..      76     294 .. 0.80
   3 ?   -4.1   4.5       2.3   5.2e+03      18      90 ..     515     585 ..     424     599 .. 0.62

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.43
                 HHHHHHCHHHHHHHHHHHHHHHHHHH.............HTT CS
    Sugar_tr 211 laklrgeedadrelaeekdsleaeqeee........kaswke 244
                 l++l +e+++++++ ee ++ e+e e++           w++
  EFC36349.1  68 LEEL-DEDEVKQKASEEEEEKEEETEKKkqqpqkvtPLPWGK 108
                 4442.3344555555555555555444422221133333333 PP

  == domain 2  score: 26.9 bits;  conditional E-value: 9.1e-10
                 TSTT--SHHHHHH...HHHHHHHTHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHH-TTTTSS-TGGGGGHHHHHHHHHHHHHHHHHHHHT CS
    Sugar_tr  31 nfglsksksskeessvlsglivsiflvGaiiGslfagllgdrfGRkkslliaavlfvigavlqaaakgknsvevlivgRvlvGigvGlasvlvPmyisE 129
                 +f+l+ + +++     ++gl+++++++ ++i+s+f g+++d +GR+++ll+++++   ++++ +++     ++  +++R+  G+  G   ++v  y++E
  EFC36349.1 136 DFNLTDNPTEYG---YYVGLVAAAYFLSQFISSFFWGTISDSIGRRPVLLFGTFFGGLCGLMFGFSR---WLWWACICRFMFGLLNGN-LGVVKSYLGE 227
                 444444444444...599*************************************************...88999*********9986.5777889*** PP

                 TS..-SCCH..HHHHHHHHHHHHHHHHHHHHHHH CS
    Sugar_tr 130 iA..pkklR..galvslyqlaitfGilvaaifgl 159
                 i+  + + R  +     + l+ ++G l++ +f  
  EFC36349.1 228 ITdsTNQARafSLTSITFGLSSVLGPLLGGVFSR 261
                 9954445553344445667777777777776665 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 2.3
                 CGGGTHHHHHHHHTSTT--SHHHHHH...HHHHHHHTHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHH CS
    Sugar_tr  18 vigafltllkfaknfglsksksskeessvlsglivsiflvGaiiGslfagllgdrfGRkkslliaavlfviga 90 
                 ++g+fl  ++ +++ ++ k +++ + s v ++ +vs  + G+i+ + +a      ++ + ++ +++v++ +  
  EFC36349.1 515 FLGTFLITNNSVSRKNYGKLNGTAQ-SFVALSRMVSPIIGGSIFAGSVAV-SKFPIDHRMVFYVITVISAVMF 585
                 4455555555555555555555333.233333333333333322221111.1222333433333333333333 PP

>> MFS_1_like  MFS_1 like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   4.3   2.6e-06    0.0059       8      71 ..     113     184 ..     108     197 .. 0.75
   2 !    9.4   2.3    0.0002      0.44     306     377 ..     194     263 ..     179     271 .. 0.82
   3 !    9.7   0.8   0.00015      0.34     106     210 ..     426     601 ..     277     609 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 2.6e-06
  MFS_1_like   8 yFfffa...algsllPYltiylkskglka......seigiitlilpltsilsppiwgvlaDrfgkrkkvvils 71 
                 +F++     ++ sl+PY+t  + + +l+       + +g++ ++  l +++s+ +wg+++D +g+r +v++++
  EFC36349.1 113 FFLYLCdslTFTSLMPYITFMIADFNLTDnpteygYYVGLVAAAYFLSQFISSFFWGTISDSIGRR-PVLLFG 184
                 4444332225789*********9999974222223579*************************987.455555 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0002
  MFS_1_like 306 lyaiienawlvlpievLhgisfgllwaaaveyvskiapksleatgqgllsglyfglGralGsliGGllwdlk 377
                 + ++ + +w++ +  ++ g+  g l +++ +y  +i+    +a+  +l s++ fgl + lG l+GG++   +
  EFC36349.1 194 MFGFSRWLWWACICRFMFGLLNGNL-GVVKSYLGEITDSTNQARAFSLTSIT-FGLSSVLGPLLGGVFSRPY 263
                 44555889***************99.99*******************98765.*************985544 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00015
  MFS_1_like 106 d.................................................................aektfwilfllvvlasfflaailvlldaatlke 139
                                                                                   ++  fw+++ l++l   ++++  +l  +  +++
  EFC36349.1 426 SsyhlglmggflgfiifvnqlfitpvviakfspltcyrwsilvdtifnvifpeiiwlvateddpmwKHVLFWSVLGLILLVRQVSNGYSFL-GTFLITN 523
                 044444444444444444444444444444445555555555558888888888888888888888999****************998766.5666777 PP

  MFS_1_like 140 lgedrkdyGr....qrlfGsvGyaifafitGilidhy.svnllp..ysallyvlaallvisllvvlilnetekesklk 210
                  +  rk+yG+       f +++ +++ +i G ++  +  v+  p   ++++yv++++  + ++++liln+   ++k +
  EFC36349.1 524 NSVSRKNYGKlngtAQSFVALSRMVSPIIGGSIFAGSvAVSKFPidHRMVFYVITVISAVMFFLSLILNKAINKPKEE 601
                 77777777652222689*********9999999975414444458877789999999888888888888877766655 PP

>> CLN3  CLN3 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   1.7e-07   0.00039     195     390 ..      39     262 ..       5     266 .. 0.71
   2 ?   -0.5   0.0      0.23   5.1e+02     150     234 ..     293     378 ..     280     397 .. 0.48
   3 ?   -0.2   0.0      0.18     4e+02     127     181 ..     551     604 ..     548     611 .] 0.60

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 1.7e-07
        CLN3 195 e........................eeseeeelleseaasaaeeeeeeesselkkslkeklklvksLllkymlPLllVYlaeYliNqgvaptllfplee 269
                 +                        ++++ eel e  + +++++eeeee++e +++ k++ ++v +L +  ++ +++ Yl + l   +++p ++f + +
  EFC36349.1  39 NlkrlvqdegsdgeensiaishhlmSSRALEELDED-EVKQKASEEEEEKEEETEKKKQQPQKVTPLPWGKLFVVFFLYLCDSLTFTSLMPYITFMIAD 136
                 022333444555556667777655422222223333.3333333333334555566788999999999999999***********************99 PP

        CLN3 270 kpfkslrdqYrvyqvlYqlgvfisR..ssvsllri.rklyllsllQvlnlvllllealyelflpsiylvfllilyeGllGG.aaYvntfaeiseeveke 364
                   +++    Y +y  l  +  f+s   ss  + +i  ++    +l +  +   l+  ++  f + +++  +  ++ Gll G +  v+ ++   ++++++
  EFC36349.1 137 FNLTDNPTEYGYYVGLVAAAYFLSQfiSSFFWGTIsDSIGRRPVLLFGTFFGGLCGLMF-GFSRWLWWACICRFMFGLLNGnLGVVKSYLGEITDSTNQ 234
                 999**********9999999999984456666677677888889988888888888888.5588899999999999*99663789999*9999999*** PP

        CLN3 365 erefslgavsv..sDslGillagllalp 390
                  r fsl+++++  s  lG ll g+++ p
  EFC36349.1 235 ARAFSLTSITFglSSVLGPLLGGVFSRP 262
                 *******987522666788887777765 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.23
        CLN3 150 vslvlPlllllsyflllekkkskkeakaeeeeeeyekleeeeeeeeeeseeeelleseaasaaeeeeeees.......selkkslkeklklv 234
                 +s++  + ++l y  l e +k++  +++  + +e+e+++++++++ ++ ++++ll++ + + +e+     +       ++l ++lk+k++ +
  EFC36349.1 293 ISSFSLVGFVLGYLKLEEANKNSWYYRKFIA-KESEEIADKHKSKGSTISKTNLLSTPTDDLEEQ-----DqepivikETLLQKLKNKFDSF 378
                 4444445566666666666555444443322.333333333333333223333322222222222.....1122234355556666666554 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.18
        CLN3 127 lvGallyalltsllglsvkatllvslvlPlllllsyflllekkkskkeakaeeee 181
                 ++G  ++a    + ++++ + ++ + v+ ++ ++++fl l  +k+ ++ k+e+++
  EFC36349.1 551 IIGGSIFAGSVAVSKFPIDHRMV-FYVITVISAVMFFLSLILNKAINKPKEEAKA 604
                 67788888888888888888765.5566667777777655555555444443333 PP

>> MFS_4  Uncharacterised MFS-type transporter YbfB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.0   1.6e-05     0.035     186     337 ..      99     259 ..      79     270 .. 0.68
   2 ?    2.5   0.0     0.031        70     146     183 ..     569     608 ..     548     611 .] 0.76

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.6e-05
       MFS_4 186 aeqkslpllalllaYgla...GfGYiitatFlvaiardgaggalleallWllvG.......laaivgvlvwlrvakrsglrralaaallieavgvllsl 274
                 ++ + lp+ +l ++++l+    + +   + ++  +++d ++       +   vG       l+ +++ + w  ++++ g r++l       +++ l+  
  EFC36349.1  99 QKVTPLPWGKLFVVFFLYlcdSLTFTSLMPYITFMIAD-FNLTDNPTEYGYYVGlvaaayfLSQFISSFFWGTISDSIGRRPVLLFGTFFGGLCGLMFG 196
                 34455666666665544322256666666666666666.333333333333334111111167789999****************************** PP

       MFS_4 275 lspsplglivssvllGltf..laitalvlqlarelappatrrllglmTasfgigQilGpllasll 337
                  s  + +  +   ++Gl    l+++++ l  +      ++ r+++l  ++fg+  +lGpll ++ 
  EFC36349.1 197 FSRWLWWACICRFMFGLLNgnLGVVKSYLGEITDST--NQARAFSLTSITFGLSSVLGPLLGGVF 259
                 ****************96422666666666655544..44799*****************98875 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.031
       MFS_4 146 sasslWlalavlsavllllvalllp..raalreasaaaea 183
                 +  ++ ++++v+sav++ l+++l +  +++++ea+a+ ea
  EFC36349.1 569 DHRMVFYVITVISAVMFFLSLILNKaiNKPKEEAKADEEA 608
                 45567899********999998887677888888887776 PP

>> MFS_3  Transmembrane secretion effector
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   1.5e-05     0.033      45     161 ..     148     258 ..     128     265 .. 0.80
   2 ?    0.4   0.9     0.071   1.6e+02     149     188 ..     543     582 ..     534     587 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.5e-05
       MFS_3  45 lmvAlvqaaatLPifllsilaGalaDnfdrRkvllavqlllalvsvlltvlaalgllspwlllaltlligiGaalndPaWqAsvgelvkrrdvpaAvaL 143
                 + v lv aa  L  f+ s + G ++D++ rR vll +  +  l  ++   +  l          + + +  G   n    +  +ge+ +  +   A  L
  EFC36349.1 148 YYVGLVAAAYFLSQFISSFFWGTISDSIGRRPVLLFGTFFGGLCGLMFGFSRWLWWACIC---RFMFGLLNG---NLGVVKSYLGEITDSTNQARAFSL 240
                 5799*********************************99988877776655554333222...222222222...33345778999999999999**** PP

       MFS_3 144 nsvginiaRsvGPAlgGv 161
                 +s+ + ++   GP lgGv
  EFC36349.1 241 TSITFGLSSVLGPLLGGV 258
                 *****************8 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.071
       MFS_3 149 niaRsvGPAlgGvlvaavGaalafavnalsylalivallr 188
                  ++R v P +gG + a   a+  f ++    + +i+++ +
  EFC36349.1 543 ALSRMVSPIIGGSIFAGSVAVSKFPIDHRMVFYVITVISA 582
                 589************************9999999999865 PP

>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1         8   1.8e+04      41      46 ..      26      31 ..      12      53 .. 0.45
   2 ?    3.2   0.0      0.06   1.3e+02      41      56 ..      81      96 ..      65     137 .. 0.66
   3 ?   -3.0   0.1       5.2   1.2e+04      37      58 ..     324     348 ..     317     361 .. 0.41
   4 ?   13.6   0.7   3.4e-05     0.076      13      51 ..     572     610 ..     571     611 .] 0.91

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 8
   OAD_gamma 41 kkakaa 46
                ++a+++
  EFC36349.1 26 EEAEET 31
                111111 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.06
   OAD_gamma 41 kkakaaaaaaaaaaaa 56
                ++++++++++++++++
  EFC36349.1 81 SEEEEEKEEETEKKKQ 96
                2222222222222221 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 5.2
   OAD_gamma  37 kkkkkkakaaaaaaaaaaaaa...e 58 
                 k++++ a++ +++ ++ ++++    
  EFC36349.1 324 KESEEIADKHKSKGSTISKTNllsT 348
                 3333333333333222222224442 PP

  == domain 4  score: 13.6 bits;  conditional E-value: 3.4e-05
   OAD_gamma  13 vVFvvLilLslvislfskiikkkakkkkkkakaaaaaaa 51 
                 +VF v++++s v+ ++s i +k  +k+k++aka+++a++
  EFC36349.1 572 MVFYVITVISAVMFFLSLILNKAINKPKEEAKADEEANK 610
                 6**********************9999999999988875 PP

>> THOC2_N  THO complex subunit 2 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   5.5   0.00053       1.2     305     372 ..      24     100 ..      18     115 .. 0.49
   2 ?   -2.0   0.0      0.45     1e+03     152     178 ..     505     531 ..     505     553 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00053
     THOC2_N 305 emealkekyekeleekssek..............gsanaLamagaLsdddDtepkkekeakkkekakkkeeeekeeepepek 372
                   e+ +e +  el+++  ++              + +  L+ + aL++ d++e     ++k++e++++keee+++++++p+k
  EFC36349.1  24 REEEAEETKTYELKKN-LKRlvqdegsdgeensiAISHHLMSSRALEELDEDEV----KQKASEEEEEKEEETEKKKQQPQK 100
                 4444444444444444.3334555688844455555556666666666554433....222233333333333333333333 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.45
     THOC2_N 152 LLrEeseGYSkLitelfttsdseepse 178
                 L r  s GYS L t l+t ++ + +++
  EFC36349.1 505 LVRQVSNGYSFLGTFLITNNSVSRKNY 531
                 778999**********99444332333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (611 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2121  (0.1183); expected 358.6 (0.02)
Passed bias filter:                      891  (0.049696); expected 358.6 (0.02)
Passed Vit filter:                       114  (0.00635841); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.98u 0.38s 00:00:01.36 Elapsed: 00:00:00.54
# Mc/sec: 3406.41
//
Query:       EFC36350.1  [L=386]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (386 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       763  (0.0425568); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2324.43
//
Query:       EFC36351.1  [L=478]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.08   13.1   2.8       0.15   12.2   0.2    2.9  3  TypeIII_RM_meth  Type III restriction/modification enzyme met
        2.8    8.1   7.6        3.9    7.7   0.7    3.5  3  Bromo_TP_like    Histone-fold protein


Domain annotation for each model (and alignments):
>> TypeIII_RM_meth  Type III restriction/modification enzyme methylation subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.57   5.1e+03      24      34 ..     145     155 ..     139     164 .. 0.70
   2 ?   -3.2   0.1       1.1   9.8e+03       1      21 [.     352     373 ..     352     377 .. 0.67
   3 ?   12.2   0.2   1.7e-05      0.15      29      49 ..     437     457 ..     436     462 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.57
  TypeIII_RM_meth  24 gvlvFdkekFa 34 
                      ++lvF++ k+ 
       EFC36351.1 145 DTLVFKRCKLK 155
                      57999998884 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.1
  TypeIII_RM_meth   1 dkeLlklL.lkneeikehFfee 21 
                      d eL+k+L +k  ++  ++fee
       EFC36351.1 352 DDELIKFLrFKGLNVDMEYFEE 373
                      6788888855666666677766 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 1.7e-05
  TypeIII_RM_meth  29 dkekFaefienkeflpdSYTk 49 
                      d+++F++++ +k+ l dSYTk
       EFC36351.1 437 DQIEFIQYLVEKKILSDSYTK 457
                      6889****************9 PP

>> Bromo_TP_like  Histone-fold protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1     0.041   3.7e+02      67      89 ..     200     222 ..     182     233 .. 0.81
   2 ?    0.5   0.1     0.071   6.4e+02      67      81 ..     348     362 ..     338     370 .. 0.83
   3 ?    7.7   0.7   0.00043       3.9      23      71 ..     396     457 ..     392     476 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.041
  Bromo_TP_like  67 dsYkrnELlsFLkyqlnlkkqlk 89 
                    + Yk++E  +F+++ +nl+ +l 
     EFC36351.1 200 ERYKTEEEKQFIEKYINLTPELL 222
                    67****************98875 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.071
  Bromo_TP_like  67 dsYkrnELlsFLkyq 81 
                    + Y+ +EL++FL+ +
     EFC36351.1 348 HYYEDDELIKFLRFK 362
                    56999*******965 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.00043
  Bromo_TP_like  23 slniltdllkyyiekillkikk............evdkdlleei.likllleeslgedsYkr 71 
                     +n+ltd lk y ek + + ++            +  +   ++i  i++l+e++++ dsY +
     EFC36351.1 396 RMNVLTDSLKKYFEKNSANFAQsvrnnfvnmnswTLSNYSEDQIeFIQYLVEKKILSDSYTK 457
                    58*****************9998888888888874444444444578888888888888865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (478 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       865  (0.0482459); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2870.23
//
Query:       EFC36352.1  [L=699]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.6e-54  185.4  13.8    2.2e-54  185.0  13.8    1.1  1  ABC_membrane  ABC transporter transmembrane region
    3.7e-36  124.7   0.0    8.4e-36  123.5   0.0    1.7  1  ABC_tran      ABC transporter
    1.6e-07   31.0   2.0    3.9e-05   23.2   0.0    2.8  3  SMC_N         RecF/RecN/SMC N terminal domain
    0.00011   22.1   0.1      0.002   17.9   0.0    2.2  2  AAA_15        AAA ATPase domain
     0.0004   20.8   0.0      0.001   19.5   0.0    1.6  1  AAA_16        AAA ATPase domain
    0.00052   20.3   0.0     0.0019   18.5   0.0    1.9  1  AAA_22        AAA domain
    0.00065   19.4   0.2     0.0016   18.1   0.2    1.6  1  AAA_29        P-loop containing region of AAA domain
     0.0059   16.4   0.2      0.034   13.9   0.0    2.3  2  AAA_30        AAA domain
     0.0076   16.3   0.0       0.14   12.2   0.0    2.5  2  AAA_5         AAA domain (dynein-related subfamily)
      0.008   15.0   0.0      0.016   14.0   0.0    1.5  1  ABC_ATPase    Predicted ATPase of the ABC class
  ------ inclusion threshold ------
      0.018   14.9   0.1       0.37   10.5   0.0    2.3  2  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
      0.041   13.8   0.0      0.098   12.6   0.0    1.6  1  RsgA_GTPase   RsgA GTPase
      0.042   13.1   0.0       0.17   11.1   0.0    1.9  2  Zeta_toxin    Zeta toxin
      0.093   13.3   0.0       0.27   11.8   0.0    1.9  1  AAA_18        AAA domain
      0.094   13.1   0.0         18    5.7   0.0    2.6  2  AAA           ATPase family associated with various cellular 
      0.095   12.8   0.3       0.44   10.6   0.0    2.1  2  DUF87         Helicase HerA, central domain
       0.14   12.4   0.4        1.3    9.3   0.4    2.3  1  SbcCD_C       Putative exonuclease SbcCD, C subunit
       0.15   12.6   2.4       0.16   12.4   0.0    2.1  2  AAA_23        AAA domain


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  185.0  13.8   2.2e-57   2.2e-54       2     272 ..      98     372 ..      97     374 .. 0.97

  Alignments for each domain:
  == domain 1  score: 185.0 bits;  conditional E-value: 2.2e-57
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHH......HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHH CS
  ABC_membrane   2 iliillailagvlsplfplvlgrildtlldkgdpet......ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsff 92 
                   +++ + ++ +gv+ + f +v+g ++d++ +k+          + ++ +++ ++++++++++++ll++++ln ++er+ ++lr+ +f+++  q+m+ff
    EFC36352.1  98 VIGAIGSLGNGVIPLCFQFVMGDLVDVFQPKNGVVPtvdsmkASVSDIAIKFAIIAAGSAVASLLSQFFLNLASERIGVALRKAYFNALTTQEMGFF 194
                   68889999**********************96666578888889***************************************************** PP

                   HHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT CS
  ABC_membrane  93 dtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsg 189
                   d +++G l+  l++dvsk+++++++kl l++q+ ++f++g++++f+++w+++l +++++pl+++   v++k+++ l+kk + a++ + s+a+E++s 
    EFC36352.1 195 DIKKTGALTVALSEDVSKIQEVYSNKLALLLQNTAQFIIGIVLAFVSSWQMSLGMISTSPLLVFGVGVLSKVVEYLTKKTNGATEHSASIATEVVSS 291
                   ************************************************************************************************* PP

                   HHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHHH CS
  ABC_membrane 190 irtVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailfg 272
                   +rtVk++g e++++++f k l++  + g+ kai++g +++   ++    +ala+w+G+ lv +++++vg+  +++++ ++lfg
    EFC36352.1 292 FRTVKSMGCEQKEQDRFAKDLKNISTYGLFKAILQGTTFASVSFILWGTIALAFWYGGGLVAENTITVGQ--MMKVFGMMLFG 372
                   **********************************************************************..****9999987 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  123.5   0.0   8.5e-39   8.4e-36       1     137 []     440     591 ..     440     591 .. 0.88

  Alignments for each domain:
  == domain 1  score: 123.5 bits;  conditional E-value: 8.5e-39
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH..................HH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren..................es 81 
                 l++ s+++k+g+ va+vG++G+GKSt++ ll + ++p+eGei +dg ++ke++ ++l+++ig+++qep lf ++ +ren                  ++
  EFC36352.1 440 LSDFSIDIKPGTSVALVGPSGSGKSTIVGLLERFYDPQEGEIIIDGYNIKEIDPQWLHRNIGIVTQEPVLFATS-IRENiayavgaenvsqeqiehaAK 537
                 67899********************************************************************9.**********99955544443333 PP

                 HTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  82 deeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                  +++++++ +l +    +t++++++ sLSgGqkqrva+ara+l++p++lllDE+t+
  EFC36352.1 538 AANCHTFIMELPD--GYETKLGEKGVSLSGGQKQRVAIARAILQDPQVLLLDEATS 591
                 3334444444444..5599999********************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.3    0.0054       5.4      27      41 ..     453     467 ..     440     474 .. 0.79
   2 !   23.2   0.0   3.9e-08   3.9e-05     135     213 ..     505     635 ..     467     644 .. 0.72
   3 ?   -1.8   0.0       1.8   1.8e+03      61     111 ..     644     693 ..     637     694 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0054
                 EEEEESTTSSHHHHH CS
                 xxxxxxxxxxxxxxx RF
       SMC_N  27 taivGpNGSGKsnll 41 
                  a+vGp GSGKs ++
  EFC36352.1 453 VALVGPSGSGKSTIV 467
                 579*********997 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 3.9e-08
                 T........................................................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHH CS
                 x........................................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 135 e........................................................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvk 177
                 +                                                        +LSgG+k+ va+a   Ai + +p  + llDe  +aLD +   
  EFC36352.1 505 QepvlfatsireniayavgaenvsqeqiehaakaanchtfimelpdgyetklgekgvSLSGGQKQRVAIAR--AILQ-DP-QVLLLDEATSALDTESEG 599
                 4444444444444444444444444455555555555555888888888888888889*******998874..4543.34.4679************** PP

                 HHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 178 kvaellkeksknaQfivislreemlekadklvgvtk 213
                  v   l++  k    i+i++r  +++++d+++ + k
  EFC36352.1 600 LVQAALDNLMKGRTSICIAHRLSTIQNCDTIYVLVK 635
                 *****************************9997766 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.8
                 CCCCC--BTTCSSTTEEEEEEEEEETTEESSSSSSCEEEEEEEETTSEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N  61 lsdlihkskekasvkkaeveitfdnedkklkiekeevsisrrvkrkgesey 111
                  ++li+k +++   k ae +++f +++ +l  +++ v+is + + k es++
  EFC36352.1 644 HHELIKK-EDGVYRKLAEKQMMFGKSEIDLIRNESAVVISPQNEVKTESSF 693
                 5678888.8889999999999999999999999999999998888877765 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.11   1.1e+02     138     227 ..      32     179 ..       1     245 [. 0.49
   2 !   17.9   0.0     2e-06     0.002      14      55 ..     440     506 ..     439     671 .. 0.76

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.11
      AAA_15 138 vekkkskkelpkekeeklekekeelkidkedlkklikkleeslkkee.................................................... 184
                 v +++++k+  +  + ++ ++ + +k++k d k+  ++++   + +                                                     
  EFC36352.1  32 VVDEQNTKSPQETATRPSRNPFKRFKKKKADEKSNVDEIKDEQEPNItgkdnmiifkifgwnwllvvigaigslgngviplcfqfvmgdlvdvfqpkng 130
                 333333333333333344444444444433333333322221111112222344444445666666666666666666666666666666666666666 PP

      AAA_15 185 ......elknvlksaiiklllisakRnvsdedsekkssllgklkekile 227
                       ++k + ++ +ik+ +i a   v + +s+   +l ++ +   l+
  EFC36352.1 131 vvptvdSMKASVSDIAIKFAIIAAGSAVASLLSQFFLNLASERIGVALR 179
                 6666666666666666666666666666555555555555555555555 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 2e-06
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnkekkn........................k 55 
                 l+d++id+++     l+G+ +sGKS+i+ +l+ F + +e                           +
  EFC36352.1 440 LSDFSIDIKPGtSVALVGPSGSGKSTIVGLLERFYDPQEGEIiidgynikeidpqwlhrnigivtqE 506
                 689*******85559********************98822224444444444444444444444440 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0     1e-06     0.001      25     161 ..     451     607 ..     441     618 .. 0.63

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1e-06
      AAA_16  25 elvllsGesGvGKsslvrellralekd......ggiflrgkcdql......esaipy....sa.laqalareellrqlldeaesaeleawrekleeala 106
                  +v l+G+sG+GKs++v  l r +  +      +     g + +       +++i       + +a+ + re +  ++++e  s+e+ ++++k     +
  EFC36352.1 451 TSVALVGPSGSGKSTIVGLLERFYDPQegeiiiD-----GYNIKEidpqwlHRNIGIvtqePVlFATSI-RENIAYAVGAENVSQEQIEHAAKAANCHT 543
                 799**************99999998885444442.....444444332334444333444423377777.77888888888666555555555555555 PP

      AAA_16 107 ...............avpelagaeasrllellkrllallsrderplvlvlDdlq.wadeaslqllaaLlrl 161
                                 + +l+g +++r++ +  r++      ++p vl+lD++   +d++s  l +a l++
  EFC36352.1 544 fimelpdgyetklgeKGVSLSGGQKQRVAIA--RAI-----LQDPQVLLLDEATsALDTESEGLVQAALDN 607
                 7777777777777555555555555555444..444.....266789999988855566666666666655 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   1.9e-06    0.0019       5     106 ..     450     602 ..     446     624 .. 0.78

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.9e-06
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaee..............erpevvfvtlpsstsskdllrellralglelka................... 70 
                  ++++++G+sG+GK+t +  l + +d ++                  +r   +  + p++   ++++++++ a+g e+ +                   
  EFC36352.1 450 GTSVALVGPSGSGKSTIVGLLERFYDPQEGEIIidgynikeidpqwlHRNIGIVTQEPVLF-ATSIRENIAYAVGAENVSqeqiehaakaanchtfime 547
                 67899*******************986655554999*********9988888999999999.99***********999999999999999999999999 PP

      AAA_22  71 .........erlsseell.ealeqalrarav...ielliiDEaqh.lr..s....e 106
                             +   l   + ++ + ara    +++l++DEa   l+  s    +
  EFC36352.1 548 lpdgyetklG-EKGVSLSgGQKQRVAIARAIlqdPQVLLLDEATSaLDteSeglvQ 602
                 9999998742.222233335555555555557778899999999878664333443 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.2   1.6e-06    0.0016      16      39 ..     444     467 ..     438     471 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.6e-06
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                 +i+i++  ++ l+GpsGsGKST++
  EFC36352.1 444 SIDIKPGTSVALVGPSGSGKSTIV 467
                 678887779*************97 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0         3     3e+03      71      97 ..      12      36 ..       4      45 .. 0.62
   2 !   13.9   0.0   3.4e-05     0.034      21     112 ..     453     604 ..     447     613 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3
      AAA_30 71 stiakllkrlkgrarlepgtllivDEa 97
                s+ a  l+  k++++ ++ t l+vDE 
  EFC36352.1 12 SNAATSLD--KEQVNSTSTTHLVVDEQ 36
                44444442..24455667799999996 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 3.4e-05
      AAA_30  21 avltGpAGtGKttalkalreaweaa.g...................................grviglAptgkaAkvLaeelgieastiakllkrlk.. 81 
                 ++l+Gp G+GK+t+++ l++ ++ + g                                   ++ i++A  ++   + + e  ++a++ + ++ +l   
  EFC36352.1 453 VALVGPSGSGKSTIVGLLERFYDPQeGeiiidgynikeidpqwlhrnigivtqepvlfatsiRENIAYAVGAENVSQEQIEHAAKAANCHTFIMELPdg 551
                 689*******************99956777777777777777777666666654333333332223333332222222223344666666666666588 PP

      AAA_30  82 ......................grarlepgtllivDEagmvdtkqlaallkaa 112
                                       +ra l++ ++l+ DEa  +  ++ + l++aa
  EFC36352.1 552 yetklgekgvslsggqkqrvaiARAILQDPQVLLLDEATSALDTESEGLVQAA 604
                 88888888888888888888876666777788888888887666666666666 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   0.00014      0.14       2      26 ..     453     478 ..     452     487 .. 0.85
   2 ?    1.1   0.0      0.37   3.7e+02      17      78 ..     533     593 ..     529     613 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00014
                 EEEE--SSSSHHHHHHHGGGGB.S-- CS
       AAA_5   2 vlLvGppGtgKselaerlaaal.nre 26 
                 v LvGp+G+gKs+++  l +++  +e
  EFC36352.1 453 VALVGPSGSGKSTIVGLLERFYdPQE 478
                 78****************99987655 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.37
                 HHGGGGBS--EEEEE--TT--HHHHH--B--.........--------G-SEEEEESGGG-- CS
       AAA_5  17 erlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraaregeilvlDEverae 78 
                 e+ a+a n+ ++++ l+++++++    ++++++g++++v  ++    + +++l+lDE + a 
  EFC36352.1 533 EHAAKAANCHTFIMELPDGYETKLGEKGVSLSGGQKQRV-AIARAILQDPQVLLLDEATSAL 593
                 778888899999999999999998889999855555554.44444778*********98765 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.0   1.6e-05     0.016     298     352 ..     537     592 ..     515     624 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.6e-05
                 EEE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS- CS
  ABC_ATPase 298 kgvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsA 352
                 k ++  +Fi +LP g +t+        SG   q ++i++a+  + ++lL+DE tsA
  EFC36352.1 537 KAANCHTFIMELPDGYETKlGEKGVSLSGGQKQRVAIARAILQDPQVLLLDEATSA 592
                 567889*************65566678****************************9 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00038      0.37       3      52 ..     454     486 ..     452     499 .. 0.73
   2 ?    1.7   0.0      0.19   1.9e+02     219     270 ..     539     593 ..     508     609 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00038
      AAA_21   3 vliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldly 52 
                 +l+Gp gsGKS++  +l+ +                  ++++ +  +d+y
  EFC36352.1 454 ALVGPSGSGKSTIVGLLERFY-----------------DPQEGEIIIDGY 486
                 89************9998775.................444444444444 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.19
      AAA_21 219 r..gvvflengdgqelparel....SdGtkrllalltallralkkgsllliDEpEngL 270
                 +  +++++e +dg+e+ + e     S G+k+  a++ a+l+++    +ll+DE  + L
  EFC36352.1 539 AncHTFIMELPDGYETKLGEKgvslSGGQKQRVAIARAILQDP---QVLLLDEATSAL 593
                 3667777777777777777655555*****9999999999999...99*****66666 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   9.8e-05     0.098      76     121 ..     426     472 ..     412     484 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 9.8e-05
                  TSEEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCT CS
  RsgA_GTPase  76 gyevllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinallp 121
                  ++++++ s  +   l++ +  +k    ++lvG+SG GKSt++  l  
   EFC36352.1 426 NVKFIYPSRPNAVVLSDFSIDIKPgTSVALVGPSGSGKSTIVGLLER 472
                  55566666666666667777777746778************998875 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00017      0.17      18      60 ..     452     494 ..     443     508 .. 0.91
   2 ?   -1.8   0.0       1.6   1.6e+03      76     112 ..     593     629 ..     587     637 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00017
  Zeta_toxin  18 lillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPe 60 
                 ++ l+G +G+GKs++  ll++  ++q++ + +d+ +++e  P+
  EFC36352.1 452 SVALVGPSGSGKSTIVGLLERFYDPQEGEIIIDGYNIKEIDPQ 494
                 6889********************************9999887 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.6
  Zeta_toxin  76 tqkdaselvekllqeaiengyniivegtlrspdvvkk 112
                  + ++  lv+ +l+ +++ + +i +   l++++++++
  EFC36352.1 593 LDTESEGLVQAALDNLMKGRTSICIAHRLSTIQNCDT 629
                 5667788999************999988888888775 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   0.00027      0.27       1      25 [.     453     485 ..     453     546 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00027
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf..........g 25 
                 ++l G++G+GK+t+   L++   +          g
  EFC36352.1 453 VALVGPSGSGKSTIVGLLERF--YdpqegeiiidG 485
                 6899**************542..333443334444 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.042        42       2      16 ..     454     468 ..     453     491 .. 0.90
   2 ?    5.7   0.0     0.018        18      44     108 ..     567     617 ..     518     629 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.042
                 EEESSTTSSHHHHHH CS
         AAA   2 llyGppGtGKTllak 16 
                  l+Gp G GK++++ 
  EFC36352.1 454 ALVGPSGSGKSTIVG 468
                 69**********985 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.018
                 HHHHHHHHHHHHTS.TSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEE CS
         AAA  44 kkirelfkeakeka.kpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkkeskviviga 108
                 +k r  +++a     +p +l++DE+ +   ++      +e  v+++L + ++g ++       i++
  EFC36352.1 567 QKQRVAIARAI--LqDPQVLLLDEATSALDTE------SEGLVQAALDNLMKGRTS-------ICI 617
                 33333344433..2469***********9999......788888889888888877.......444 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.2       2.1   2.1e+03     153     193 ..      34      70 ..       9      88 .. 0.63
   2 ?   10.6   0.0   0.00044      0.44      24      58 ..     451     483 ..     441     486 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 2.1
       DUF87 153 ekeelrklknqaiarlldkledllrkggsfsnsstdliall 193
                  +++ +++++ a +   ++++++++k+++     +++++++
  EFC36352.1  34 DEQNTKSPQETATRPSRNPFKRFKKKKADE----KSNVDEI 70 
                 455677777777777778888888888887....4444444 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00044
       DUF87  24 rHlAilgsTGsGKSntvavLleellekkgatilil 58 
                  ++A +g +GsGKS+ v++ le+ + +++   +i+
  EFC36352.1 451 TSVALVGPSGSGKSTIVGL-LERFY-DPQEGEIII 483
                 679**************96.57777.555544454 PP

>> SbcCD_C  Putative exonuclease SbcCD, C subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.4    0.0013       1.3      19      82 ..     549     599 ..     534     607 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0013
     SbcCD_C  19 edgkekelsrssgtlSGGekqflaylalaaalaalyssaegrepalrlvfLDEAFsklDeesia 82 
                 +dg e++l ++  +lSGG+kq    +a+a   +a +++       +++++LDEA s lD es  
  EFC36352.1 549 PDGYETKLGEKGVSLSGGQKQR---VAIA---RAILQD-------PQVLLLDEATSALDTESEG 599
                 4778888888888888888843...3444...334444.......899***********99865 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   1.2       3.5   3.5e+03     131     163 ..      44      75 ..       2      86 .. 0.40
   2 ?   12.4   0.0   0.00016      0.16      11      36 ..     441     467 ..     421     471 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3.5
      AAA_23 131 ilnlilflgqerfeefelkdkkerleelekele 163
                   ++ +  + +rf +++++d+k+ ++e+++e+e
  EFC36352.1  44 TATRPSRNPFKRF-KKKKADEKSNVDEIKDEQE 75 
                 2222222222222.1222333444444444444 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 0.00016
      AAA_23  11 rdqeidFskg.ltlItGpNGaGKTTil 36 
                 +d++id ++g  ++++Gp G+GK+Ti+
  EFC36352.1 441 SDFSIDIKPGtSVALVGPSGSGKSTIV 467
                 78899999963679************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (699 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       934  (0.0520944); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              18  [number of targets reported over threshold]
# CPU time: 0.79u 0.35s 00:00:01.14 Elapsed: 00:00:00.51
# Mc/sec: 4111.51
//
Query:       EFC36353.1  [L=136]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.8e-09   35.9   0.0    7.6e-09   35.6   0.0    1.1  1  MAPEG     MAPEG family


Domain annotation for each model (and alignments):
>> MAPEG  MAPEG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.6   0.0   4.2e-13   7.6e-09       2     128 ..      10     121 ..       9     123 .. 0.86

  Alignments for each domain:
  == domain 1  score: 35.6 bits;  conditional E-value: 4.2e-13
                 HHHHHHHHHHHHHHHHHHHHHHHHTT--SS---S......SH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.T-HHHHHHHHHHHHHHHHHHHHH CS
       MAPEG   2 alyagllallllllslivvkerrkakiaigegkanapralddklppklqrairahgNflEyvplfllavllaeltgaetglaallaaafvvaRvlhalg 100
                 al + l +l +  +++ v+++r+   ++    +         + pp +  a r++ N +E++  fl a++l+  +  ++ l  ++++++ ++Rv + +g
  EFC36353.1  10 ALSSSLVILAQSKATFMVGRARKEFHVKP---P-------LTEGPPGFLNALRVQLNGVENIASFLGALWLCTGMLENDYLGGGVGLLYAIGRVWYGYG 98 
                 56677888889999999999999999943...2.......55568899*************************99778********************* PP

                 HHH-..SGGGHHHHHHHHHHHHHHHHHH CS
       MAPEG 101 yiaggpppgRslgflltllvllvlslla 128
                 y ++     R  gf+l  +++ + +l++
  EFC36353.1  99 YPEK-----RLPGFILCQICTNSCLLAC 121
                 *888.....8888888888887777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       324  (0.0180713); expected 358.6 (0.02)
Passed bias filter:                      229  (0.0127726); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.29s 00:00:00.71 Elapsed: 00:00:00.43
# Mc/sec: 941.29
//
Query:       EFC36354.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.039   14.4   0.3      0.054   14.0   0.3    1.3  1  Afi1             Docking domain of Afi1 for Arf3 in vesicle t
       0.17   11.2   0.8         13    5.1   0.1    2.1  2  DNA_pol3_finger  Bacterial DNA polymerase III alpha subunit f


Domain annotation for each model (and alignments):
>> Afi1  Docking domain of Afi1 for Arf3 in vesicle trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.3     6e-06     0.054      36      94 ..      18     110 ..      12     148 .. 0.54

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 6e-06
        Afi1  36 mlPdqvhkrkqDitvF................fLykdtsteeeeleeeek.....................................knklekrkkkks 81 
                 mlP  + krkqD+t F                                 +                                     +++  +rk+kk+
  EFC36354.1  18 MLPTRIGKRKQDKTSFqfignanlkvlettcnN----------------SmfavfqysekinttpmegvllmkgmdmegssthrrkvSKQTPTRKSKKT 100
                 ****************66666655544444440................23444444445555566666666666655442211000222222222222 PP

        Afi1  82 ededdvdeedeee 94 
                 e   +v ++++ +
  EFC36354.1 101 E---SVVQDSTTS 110
                 2...222222222 PP

>> DNA_pol3_finger  Bacterial DNA polymerase III alpha subunit finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1    0.0019        17      10      48 ..      21      59 ..      14      67 .. 0.86
   2 ?    5.1   0.1    0.0014        13     122     160 ..      67     105 ..      65     112 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0019
                     HHHHHHH-----GGG--S--HHHHHHHHHT--TTSTT-- CS
  DNA_pol3_finger 10 klikekkgkeidleeipleDkkvykllskgdtlGvfqle 48
                     ++i ++k+ + +++ i + + kv+++ +++++++vfq  
       EFC36354.1 21 TRIGKRKQDKTSFQFIGNANLKVLETTCNNSMFAVFQYS 59
                     678888899999999**********************76 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0014
                      HHHHHHHH---HHHHHHHHHHHHH--HHHHHHHHHHHHH CS
  DNA_pol3_finger 122 mqiaqvlagfslgeAdllrramgkkkeeeleklkekfie 160
                      m+ ++ ++g++++ + + rr+++k+ +   +k++e++++
       EFC36354.1  67 MEGVLLMKGMDMEGSSTHRRKVSKQTPTRKSKKTESVVQ 105
                      5667789*****************888887777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1130  (0.0630264); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1065.58
//
Query:       EFC36355.1  [L=493]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.9   0.0       0.68   10.4   0.0    2.3  2  DUF4350   Domain of unknown function (DUF4350)


Domain annotation for each model (and alignments):
>> DUF4350  Domain of unknown function (DUF4350)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   3.8e-05      0.68      34      65 ..     125     157 ..     111     158 .. 0.81
   2 ?   -3.1   0.0      0.63   1.1e+04      33      48 ..     245     260 ..     237     265 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 3.8e-05
     DUF4350  34 edgtllvvapdlrlte.eelaallewvarGntl 65 
                 + +t ++v++++   + ++  a+l +v++Gntl
  EFC36355.1 125 RVTTTVLVDNHFQQQQqQQQHAILPMVDNGNTL 157
                 457999999998888877788***********8 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.63
     DUF4350  33 gedgtllvvapdlrlt 48 
                 ++  t+l+++p+   +
  EFC36355.1 245 QAYETVLNFNPGSASS 260
                 5677999999994444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (493 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2752  (0.153494); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.83u 0.34s 00:00:01.17 Elapsed: 00:00:00.55
# Mc/sec: 2713.40
//
Query:       EFC36356.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0056   17.1   3.4     0.0056   17.1   3.4    3.1  3  SPAN-X    Sperm protein associated with nucleus, mapped to X 


Domain annotation for each model (and alignments):
>> SPAN-X  Sperm protein associated with nucleus, mapped to X chromosome
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   3.4   3.1e-07    0.0056      19      83 ..       4      70 ..       2      73 .. 0.90
   2 ?   -0.1   0.9     0.071   1.3e+03      40      76 ..     128     165 ..     107     182 .. 0.55
   3 ?   -2.1   3.1      0.31   5.5e+03      16      39 ..     213     235 ..     207     250 .] 0.47

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3.1e-07
      SPAN-X 19 SnnkendemqetpngdsapeqslkKlKtseystilvlsyrkkkKi..ssnqlendqsrensinpvQe 83
                S+ ++n+e   t + d+a  +++k +K+     +l+ +y+  +     sn++ n  s   +inpvQ 
  EFC36356.1  4 SSFQQNQEHSVTDSEDLAKSPAIKPIKKTRRKKTLMEHYKIIESPpkDSNNISNSTSTFSTINPVQS 70
                5567999*****************************99*987766669******************6 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.071
      SPAN-X  40 slkKlKtseystilvlsyrkkkKi.ssnqlendqsren 76 
                   kK+  s++  +  ls + ++   + n +++ +sr++
  EFC36356.1 128 NTKKIIHSNSEKTSLLSNNSSTPLsNNNTIKKRKSRNE 165
                 44444444443333333333333324444444444444 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.31
      SPAN-X  16 pceSnnkendemqetpngdsapeq 39 
                 +++Sn+ +  + + t ++   p+q
  EFC36356.1 213 SSNSNQ-RVKTPPTTTTRSWSPHQ 235
                 444444.44444555555544444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1075  (0.0599587); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1536.50
//
Query:       EFC36357.1  [L=1318]
Description: hypothetical protein NAEGRDRAFT_75989 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.2e-16   60.9   0.0    2.8e-16   59.7   0.0    1.6  1  G8          G8 domain
  ------ inclusion threshold ------
        1.9    8.3  15.7       0.83    9.5   0.7    4.0  4  Beta_helix  Right handed beta helix region


Domain annotation for each model (and alignments):
>> G8  G8 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.7   0.0   3.1e-20   2.8e-16      16     123 .]      51     165 ..      44     165 .. 0.88

  Alignments for each domain:
  == domain 1  score: 59.7 bits;  conditional E-value: 3.1e-20
          G8  16 Ipagktvlldvsspk.lrsllve..GtLifsddksdielnaeyilvqggGkleiGteeepfkgkatItLyG......teewsstelpdlgaKvlavsng 105
                 I+ ++ v +d+s+p+ lrs++v   G+Lif d+  +++ln++ i v++g+++++G+ ++p+++k+ +t+yG      +  +++ ++ ++g+K+++  +g
  EFC36357.1  51 ITISTAVKVDKSPPNkLRSITVLngGSLIF-DN-TNLTLNVDFIRVESGASWIMGSATCPITSKIVLTFYGarttenDIGTDPFDNVNMGSKGIGFLSG 147
                 5557789999666554******99******.77.8************************************998766556666779************* PP

          G8 106 GtlelhGqprkktwtkLa 123
                  +++++Gq   +t t La
  EFC36357.1 148 SKVQIFGQVDYPTFTDLA 165
                 ***************996 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0      0.81   7.3e+03      61     101 ..      48      83 ..      33      94 .. 0.56
   2 ?    9.5   0.7   9.2e-05      0.83      11     138 ..     290     420 ..     271     437 .. 0.60
   3 ?    7.9   0.8   0.00029       2.6      12      93 ..     495     589 ..     459     661 .. 0.72
   4 ?   -2.9   0.3      0.59   5.3e+03      48      48 ..    1098    1098 ..    1037    1175 .. 0.57

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 0.81
                 S-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-TT-S CS
  Beta_helix  61 nntisdnngggialfgasnnlienneitdnggsGiylnyss 101
                 +++i+ ++  +++++++ +n ++  ++ + g+    +++++
  EFC36357.1  48 DSQITIST--AVKVDKSPPNKLRSITVLNGGS---LIFDNT 83 
                 44444333..6666666666666666666644...222333 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 9.2e-05
                 .EEESEEEES-SS-SEEE-SSS-..EEES-EEES-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-TT-S-..-EEE CS
  Beta_helix  11 vtiknntisnsggyGiylrgssn.vvienneiannsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdnggsGiylnyssn..ntie 106
                 +++++ +i++ g+yG++ r s + +++e n+ ++      ++   +   i++++++d+ +    + ++++ l+++n +++ +g+ ++l++ s   n+++
  EFC36357.1 290 FQVEGIEIRKFGQYGLMGRYSFHlHLLE-NTAQG-----TALG--TQYYIKGCSVHDSFQRCYVVHDTNYFLLQDNVCFNANGHCYFLEDGSEvgNVFK 380
                 5566666666666666666666633333.44444.....2222..334688888888887777777888888888888888888888877444346666 PP

                 S-EEESTT.....--SEE---TT...---EEES-EEES-S CS
  Beta_helix 107 nNiidnna.....gsGividdss...snvtvtnNtitnnk 138
                 +N     +     ++ +  +ds+    ++t  nNt+++n 
  EFC36357.1 381 HNLGIRPKpvydlAYRLIPSDSDvavFWITNPNNTFVDNH 420
                 6554444444444333333333344444444444444444 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.00029
                 EEESEEEES-SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---.....................SEEE-TT--S--EEES-EEES CS
  Beta_helix  12 tiknntisnsggyGiylrgssnvvienneiannsgsGiyilgssnntisnntisdnn.....................gggialfgasnnlienneitd 89 
                  i+n+t +++ gyGi++r ++  v++n ++++ ++  +    +  + i+++                            +  +++++  ++i++ e +d
  EFC36357.1 495 LIDNFTAYKMRGYGIWARCGNI-VFKNLYLTD-NMRQMNSPPG-TSYITDS-----ImiaesenvgdytlrpsvdignRTRPNAYYSTTTVIKGYETYD 585
                 4778888888888888877776.888877777.4444444432.2222222.....0222222345555666666666688888889999999988888 PP

                 -SS- CS
  Beta_helix  90 nggs 93 
                 ngg+
  EFC36357.1 586 NGGA 589
                 8875 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 0.59
                  S CS
  Beta_helix   48 G 48  
                  G
  EFC36357.1 1098 G 1098
                  2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       466  (0.0259914); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.85u 0.32s 00:00:01.17 Elapsed: 00:00:00.52
# Mc/sec: 7678.55
//
Query:       EFC36358.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-16   61.0   0.1    3.3e-16   60.1   0.0    1.5  2  Peptidase_C39_2  Peptidase_C39 like family


Domain annotation for each model (and alignments):
>> Peptidase_C39_2  Peptidase_C39 like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0      0.79   1.4e+04      86     102 ..      57      73 ..      35      87 .. 0.54
   2 !   60.1   0.0   1.9e-20   3.3e-16       2     144 .]     224     358 ..     223     358 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 0.79
  Peptidase_C39_2  86 gssieevkkeidagkPv 102
                       +  +++kk+ +++k +
       EFC36358.1  57 RRRKQTIKKKTKNDKEI 73 
                      33333333333333333 PP

  == domain 2  score: 60.1 bits;  conditional E-value: 1.9e-20
  Peptidase_C39_2   2 dvplynQlde..............lpngCeptslamvlsylgk.kvtqnelakelktnssgdpntgfvgnitdksglgvynepivklaekyglk 80 
                      ++pl++Q+d               +++gC +ts+ + l+  gk k+++ e++++lktn+      gf     ++++l+v++++++k++ ky + 
       EFC36358.1 224 QFPLLKQCDStwgsfklgtssetiCKAGCLITSIISGLNGIGKtKMNPYEFNEWLKTNG------GF-----QNKNLYVWAAITSKFGVKYYG- 305
                      79******9899*******************************89*************8......55.....68999***************9. PP

  Peptidase_C39_2  81 vsdtrgssi.eevkkeidagkPvvvsvttfkplndgeikftssgHlvvitGYdekgkrvyvnDPa 144
                          r+++i   +++++++gk v++ +  +kp+      +++s+H+v+ tGYd  +k++ v+DP+
       EFC36358.1 306 ----RTTDIlVVATRNLCEGKLVILKL--IKPP------GKKSEHFVLATGYDPVSKTFSVMDPY 358
                      ....4444438899*************..6766......9**************9999******8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1242  (0.0692732); expected 358.6 (0.02)
Passed bias filter:                      713  (0.039768); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 2106.33
//
Query:       EFC36359.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.7e-22   78.2   0.2    1.5e-05   24.8   0.0    5.1  5  NHL           NHL repeat
      2e-07   30.9   0.0      2e-05   24.3   0.0    3.2  1  SGL           SMP-30/Gluconolactonase/LRE-like region
    2.2e-07   30.4   2.3      2e-06   27.2   0.6    2.6  3  DUF5128       6-bladed beta-propeller
    2.9e-06   27.4   0.1      0.047   13.9   0.0    4.3  4  Arylesterase  Arylesterase
    0.00079   19.3   1.0     0.0047   16.8   0.2    2.4  2  DUF4934       Domain of unknown function (DUF4934)
     0.0012   18.5   0.0     0.0029   17.2   0.0    1.6  1  PQQ_2         PQQ-like domain
      0.002   18.0   0.0        4.3    7.4   0.0    3.9  3  PQQ           PQQ enzyme repeat
     0.0074   16.4   0.4         18    5.5   0.0    3.8  4  Str_synth     Strictosidine synthase
  ------ inclusion threshold ------
       0.14   11.7   0.6         18    5.0   0.0    2.3  2  AcrZ          Multidrug efflux pump-associated protein AcrZ


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.1   2.3e+03      11      19 ..      81      89 ..      78      95 .. 0.80
   2 !    8.2   0.0    0.0013       2.6      10      27 ..     147     165 ..     143     166 .. 0.85
   3 !   24.8   0.0   7.4e-09   1.5e-05       1      28 []     187     214 ..     187     214 .. 0.94
   4 !   15.6   0.0   6.2e-06     0.012       1      26 [.     234     260 ..     234     262 .. 0.93
   5 !   22.9   0.0     3e-08     6e-05       1      28 []     281     309 ..     281     309 .. 0.97

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.1
                TTTEEEEEE CS
         NHL 11 snGdiyVaD 19
                s G iy+ D
  EFC36359.1 81 SEGFIYILD 89
                899****99 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0013
                 E.TTTEEEEEECCCTEEEE CS
         NHL  10 d.snGdiyVaDsenhrvqv 27 
                 + s+++iyV++ ++++++v
  EFC36359.1 147 ScSSDQIYVTCKKTNSIKV 165
                 339*************998 PP

  == domain 3  score: 24.8 bits;  conditional E-value: 7.4e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 + +Ph++++d   +i+V+Ds+nhr+q F
  EFC36359.1 187 LLFPHDLTLDLEENIIVCDSGNHRIQAF 214
                 569***********************88 PP

  == domain 4  score: 15.6 bits;  conditional E-value: 6.2e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvq 26 
                 f +P G+a+d +++ i+V+D+ n+r+q
  EFC36359.1 234 FESPKGIAYDkKTNMILVSDTMNNRIQ 260
                 568***********************9 PP

  == domain 5  score: 22.9 bits;  conditional E-value: 3e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 f +P G+a++   G+++VaD++nh +++F
  EFC36359.1 281 FMRPVGLAISyGLGELFVADFGNHMIHIF 309
                 789**********************9999 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   0.0     1e-08     2e-05       8     220 ..      69     319 ..      66     325 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 1e-08
         SGL   8 deeegaLlwvDilgqrihrldpatgketv........................................ldtpesvGaiaprkdgrlvvasksglall. 65 
                  e+e++L+++D+ ++ i+ ld++t++                                           +++p+ +G+ +   d+  v+++k++ + + 
  EFC36359.1  69 NEKERRLYFTDVSEGFIYILDLDTRQVLKrmlvdglpsyfdyfddkfvlstdrgivqcinmengkinwtTEIPGANGVSCS-SDQIYVTCKKTNSIKVl 166
                 57899*******************9988799**********************************9988889999999999.88888888888777666 PP

         SGL  66 dlasgeletladeee.dekpllrfNDgvvdpdGrlwfGtmgdeeakgeev..galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiway 161
                   +sge+  +++e   +e +ll + D+  d + ++++ + g+++ +  ++  + ly + ++gk +     +  p G+a ++ ++ +++ D+++++i+ +
  EFC36359.1 167 SKRSGEVLSVISERGrKEGQLLFPHDLTLDLEENIIVCDSGNHRIQAFKKdgTFLYSIGKQGKEN---GCFESPKGIAYDKKTNMILVSDTMNNRIQLF 262
                 66777776666663336668999****************99999887666657888888886654...45788************************** PP

         SGL 162 dvdaeggklsnrrvfadlkkge...gepDGlavDa.eGnvwvAvwgggkvvrfdpdGklieei 220
                 d ++        + f ++k+++    +p Gla+    G+++vA +g++ ++ f +  k ++ i
  EFC36359.1 263 DHKKAFV-----KSF-KVKNDDlafMRPVGLAISYgLGELFVADFGNHMIHIFVNWSKKVHNI 319
                 *964444.....223.4445445565699*****999***********999998877777666 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.64   1.3e+03     106     143 ..      68     105 ..      60     122 .. 0.67
   2 !    8.3   0.0   0.00056       1.1      58     120 ..     146     208 ..     137     211 .. 0.87
   3 !   27.2   0.6     1e-09     2e-06      62     136 ..     198     271 ..     193     284 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.64
     DUF5128 106 idksnesIyildfmknkiltYdLegykfieekkldllv 143
                 ++++++++y  d  ++ i + dL++ + ++   +d l+
  EFC36359.1  68 VNEKERRLYFTDVSEGFIYILDLDTRQVLKRMLVDGLP 105
                 67777777777777777777777776666665555555 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00056
     DUF5128  58 ikvvdkrifvlDsaknnlfvFd.kkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmk 120
                 +  + ++i+v+ + +n + v +  +G+  + I+++G   g  l  +d ++d ++ +I++ d+ +
  EFC36359.1 146 VSCSSDQIYVTCKKTNSIKVLSkRSGEVLSVISERGRKEGQLLFPHDLTLDLEE-NIIVCDSGN 208
                 677889****************889**************************655.777788865 PP

  == domain 3  score: 27.2 bits;  conditional E-value: 1e-09
     DUF5128  62 dkrifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknkiltYdLegykfiee 136
                 ++ i+v Ds + ++  F k+G f + Ig+qG+  g + + + ++ dk+ + I + d m+n+i  +d +   f++ 
  EFC36359.1 198 EENIIVCDSGNHRIQAFKKDGTFLYSIGKQGKENGCFESPKGIAYDKKTNMILVSDTMNNRIQLFDHKK-AFVKS 271
                 678***************************************************************877.77765 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.28   5.7e+02      57      82 ..      64      89 ..      37      93 .. 0.79
   2 ?    2.2   0.0       0.1     2e+02      54      83 ..     141     168 ..     129     171 .. 0.81
   3 !   13.9   0.0   2.4e-05     0.047      41      82 ..     222     263 ..     213     267 .. 0.82
   4 ?    4.2   0.0     0.024        49      45      81 ..     273     309 ..     266     315 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.28
  Arylesterase 57 nGInidadkkyiyvadilresihvmk 82
                    + ++ +++ +y +d+ +  i++++
    EFC36359.1 64 YQVRVNEKERRLYFTDVSEGFIYILD 89
                  55778899999******999999986 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.1
  Arylesterase  54 ssanGInidadkkyiyvadilresihvmkk 83 
                     anG+  ++d+  iyv+    +si v+ k
    EFC36359.1 141 PGANGVSCSSDQ--IYVTCKKTNSIKVLSK 168
                   569999999997..9999999999988776 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 2.4e-05
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresihvmk 82 
                   ys ++  +    ++s+ GI +d +  +i v+d +++ i  ++
    EFC36359.1 222 YSIGKQGKENGCFESPKGIAYDKKTNMILVSDTMNNRIQLFD 263
                   5666666667789***********************997665 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.024
  Arylesterase  45 evkvvasglssanGInidadkkyiyvadilresihvm 81 
                   +vk+    +  + G+ i+     ++vad  ++ ih++
    EFC36359.1 273 KVKNDDLAFMRPVGLAISYGLGELFVADFGNHMIHIF 309
                   6666667899999**********************86 PP

>> DUF4934  Domain of unknown function (DUF4934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.42   8.5e+02      29      62 ..     146     181 ..     136     186 .. 0.75
   2 !   16.8   0.2   2.3e-06    0.0047      29     100 ..     195     268 ..     184     270 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.42
     DUF4934  29 ikllkdkivvss..kkqCllfdketGkflasvGhiG 62 
                 +  + d+i v+    ++  +++k++G  l+ +  +G
  EFC36359.1 146 VSCSSDQIYVTCkkTNSIKVLSKRSGEVLSVISERG 181
                 667789999998433456789999999999887776 PP

  == domain 2  score: 16.8 bits;  conditional E-value: 2.3e-06
     DUF4934  29 ikllkdkivvss.kkqCllfdketGkflasvGhiGedPegysevagw.lndatgl.lyfsrkpdklvkydakGef 100
                 + l ++ iv  s +++ ++f k++G fl s+G +G++   + +  g+ ++++t++ l     +++++ +d+k  f
  EFC36359.1 195 LDLEENIIVCDSgNHRIQAF-KKDGTFLYSIGKQGKENGCFESPKGIaYDKKTNMiLVSDTMNNRIQLFDHKKAF 268
                 55666666667767777888.669************999888875541555555414555678888888887666 PP

>> PQQ_2  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   1.4e-06    0.0029       3     121 ..      83     196 ..      81     218 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.4e-06
       PQQ_2   3 gvvsaldaatGaelWrvdlarplgggvsravlsggtlfvatgggrlvaldaatGkvlWettlegpvvgaplvaegrvvvva.sdgqlialdaedGkrlW 100
                 g ++ ld +t ++l r+ l ++l + +   +  +++++  t++g + +++ ++Gk+ W+t+ +g   g    + ++++v     +++  l++++G++l 
  EFC36359.1  83 GFIYILDLDTRQVLKRM-LVDGLPSYF--DY-FDDKFVLSTDRGIVQCINMENGKINWTTEIPGA-NGV-SCSSDQIYVTCkKTNSIKVLSKRSGEVLS 175
                 66889999999999999.434566677..88.666666668*********************998.444.69999999988456699999999999986 PP

       PQQ_2 101 stqqrseepaelrssaspava 121
                  + +r+ +   l+ + + +++
  EFC36359.1 176 VISERGRKEGQLLFPHDLTLD 196
                 666666544445555555555 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.081   1.6e+02       4      19 ..      76      92 ..      73      96 .. 0.83
   2 !    7.4   0.0    0.0021       4.3       4      31 ..     115     143 ..     112     147 .. 0.86
   3 ?    3.0   0.0     0.054   1.1e+02       2      23 ..     152     174 ..     151     186 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.081
                EEE.ETTSEEEEEETTT CS
         PQQ  4 ylg.sadGylyAlDadT 19
                y +    G +y lD+dT
  EFC36359.1 76 YFTdVSEGFIYILDLDT 92
                66667789*******99 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0021
                 EEE.ETTSEEEEEETTTCCEEEEEESSSC CS
         PQQ   4 ylg.sadGylyAlDadTGkvlWrfktggp 31 
                 ++  ++ G +  +++++Gk+ W+++++g+
  EFC36359.1 115 FVLsTDRGIVQCINMENGKINWTTEIPGA 143
                 66778999999*************99987 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.054
                 EEEEE.ETTSEEEEEETTTCCEE CS
         PQQ   2 vvylg.sadGylyAlDadTGkvl 23 
                  +y++  + + +  l  ++G+vl
  EFC36359.1 152 QIYVTcKKTNSIKVLSKRSGEVL 174
                 689999***************98 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.0    0.0092        18       2      21 ..      65      84 ..      64     102 .. 0.83
   2 ?    4.5   0.0     0.019        37      57      78 ..     141     162 ..     136     169 .. 0.79
   3 ?    0.5   0.0      0.35   6.9e+02      59      82 ..     237     260 ..     234     267 .. 0.85
   4 ?    0.8   0.0      0.26   5.3e+02      34      75 ..     254     300 ..     241     311 .. 0.65

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0092
   Str_synth  2 aldvdeetgvlyftdsSsky 21
                ++ v+e++  lyftd S+ +
  EFC36359.1 65 QVRVNEKERRLYFTDVSEGF 84
                6789*************977 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.019
   Str_synth  57 yfanGialsedgsfvlvcetam 78 
                  +anG++ s+d+ +v   +t  
  EFC36359.1 141 PGANGVSCSSDQIYVTCKKTNS 162
                 689**********998777665 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.35
   Str_synth  59 anGialsedgsfvlvcetamkris 82 
                 + Gia  +  + +lv++t  +ri+
  EFC36359.1 237 PKGIAYDKKTNMILVSDTMNNRIQ 260
                 789999999999999999999975 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.26
   Str_synth  34 dktGrllkydkst...kvvkvlldkLyf..anGialsedgsfvlvce 75 
                   + r+  +d+++   k+ kv  d+L+f  + G+a+s     + v++
  EFC36359.1 254 TMNNRIQLFDHKKafvKSFKVKNDDLAFmrPVGLAISYGLGELFVAD 300
                 45567777777763336677888999995556888887665555555 PP

>> AcrZ  Multidrug efflux pump-associated protein AcrZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0    0.0091        18      30      44 ..     171     185 ..     170     187 .. 0.91
   2 ?    4.7   0.1     0.011        23      17      33 ..     285     297 ..     279     303 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0091
        AcrZ  30 GEvfNviSkiGhrke 44 
                 GEv  viS+ G+++ 
  EFC36359.1 171 GEVLSVISERGRKEG 185
                 9***********985 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.011
        AcrZ  17 vvmAiiLglIygLGEvf 33 
                 v +A    + ygLGE+f
  EFC36359.1 285 VGLA----ISYGLGELF 297
                 4444....46******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       418  (0.0233142); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2135.92
//
Query:       EFC36360.1  [L=605]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.4e-21   76.5   5.6    1.5e-13   51.0   2.6    2.4  2  mRNA_cap_enzyme  mRNA capping enzyme, catalytic domain
    1.6e-09   38.4   0.1    1.2e-08   35.5   0.0    2.5  2  mRNA_cap_C       mRNA capping enzyme, C-terminal domain


Domain annotation for each model (and alignments):
>> mRNA_cap_enzyme  mRNA capping enzyme, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.1   6.4e-10   5.7e-06       3      37 ..      40      74 ..      38     149 .. 0.80
   2 !   51.0   2.6   1.7e-17   1.5e-13      40     195 .]     154     327 ..     131     327 .. 0.78

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 6.4e-10
                     EE--TTHHHHHHHS-EEEEEEESSEEEEEEEEECT CS
  mRNA_cap_enzyme  3 vSlerenlekLkqkkYvvseKaDGiRylmllteee 37
                     v l+r +l++L++++Y+++eK+DGiR + l+ +++
       EFC36360.1 40 VQLSRTSLHLLSEHDYYITEKSDGIRAMCLMLRSK 74
                     7899************************9998876 PP

  == domain 2  score: 51.0 bits;  conditional E-value: 1.7e-17
                      EEEEETTS-EEE.ESSST-BTTSSSST......CTSBGGSEEEEEEEEEEECTTCEEEEEEEEEEEEEETTEEGTT...SBHHHHHHHHHHHTH CS
  mRNA_cap_enzyme  40 vylidRenevyr.venlrfprekdkek......lekvldetllDgElvidkveekkkelryliyDivaingvtvae...eplskRleilkkeli 123
                       +++dR +e+y+ +e++ fp + + ++      + +++d  +lDgE+v +  e+   +  y iyD++ +   +v +   e +++R+e+++k + 
       EFC36360.1 154 SFFFDRTFEFYLsIEEIAFPSRDNINRktktleECRYQDIVILDGEIVFNLKEQ---RNNYSIYDLITFCKEKVISaraESMNNRYEFIEKYIT 244
                      599*******955*******998754433454445678899*******987766...689*******9988777542226789*********** PP

                      HHHHHHHHTTCCCCTTSSSEEEE--EEETTHHHHHHH........HCCCCCTTSTEEEEEEEESSS...B--SEEEEEEEEE- CS
  mRNA_cap_enzyme 124 kprneekktglletdkepfsvrlKefilleavaklle........ekfikklshesDGLIfqpvke...pyvagrdsdllKwK 195
                      +p+ ++ k  l +   + +++ +K+f+  +++  ++e         + + k   ++DGL+f+p+++    +++g ++ llKwK
       EFC36360.1 245 DPHYHYYKIILKRDPPKCLKLIRKHFYEKSKLMEVMEcikedpetGEYLYKNYNKNDGLVFTPKDAvlsAFKPGANNYLLKWK 327
                      ******9988888889999*******998887765431111111123444555689********973336899*********9 PP

>> mRNA_cap_C  mRNA capping enzyme, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.77   6.9e+03      56      68 ..      87     102 ..      53     133 .. 0.63
   2 !   35.5   0.0   1.3e-12   1.2e-08      24     107 ..     360     443 ..     333     444 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.77
                 S--TTE...EEEEEE- CS
  mRNA_cap_C  56 eeldgk...IvEcsld 68 
                 +++d k    +Ec ++
  EFC36360.1  87 QQFDLKnncAIECIYH 102
                 3332222235666555 PP

  == domain 2  score: 35.5 bits;  conditional E-value: 1.3e-12
                 EEEEESTEEEEEEEB---HH...HHHHHHHT-.S--TTEEEEEEE-TT.S-EEEEEE-TT-SS--BHHHHHHHHHHHHTS--HHHH CS
  mRNA_cap_C  24 llvlegekyekfaelylseeekeeweelksln.eeldgkIvEcsldee.krWkllriRdDKsepNhisvvekvleSIednvteeeL 107
                 ++ +  + ++ f+++++++  ++ + ++   + ++  g IvE+ +d++ + W +l iR+DK++pN +++v +++e + +n+t+++L
  EFC36360.1 360 VYFQFSKISHFFDTVQVKDISPHILAKFL--DlQKGTGLIVEMGFDSTkSGWYFLLIREDKTSPNAFKTVANTVENMIENITIDDL 443
                 44444455666666666666444444444..23566788*******76356*********************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (605 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       822  (0.0458475); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 3535.26
//
Query:       EFC36361.1  [L=802]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-53  181.5   0.1    2.8e-53  181.0   0.1    1.2  1  Pkinase         Protein kinase domain
    1.1e-23   83.9   0.3    4.8e-23   81.8   0.3    1.9  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0017   18.3   0.0        0.3   11.0   0.0    2.2  2  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.012   15.3   2.3      0.031   13.9   1.7    1.9  2  Choline_kinase  Choline/ethanolamine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.0   0.1   6.2e-57   2.8e-53       1     264 []     497     794 ..     497     794 .. 0.87

  Alignments for each domain:
  == domain 1  score: 181.0 bits;  conditional E-value: 6.2e-57
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS......CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH.HH CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk......hpnivrlyevfeekdelylvleyveggeladlle.rk 92 
                 ye++  lG+GsfG+V+ka++ +++k vA+K+i+++k+ +    ++l E+kilk+lk        + ++++ +f+  ++l++ +e+++ + l ++++ ++
  EFC36361.1 497 YEVVGFLGKGSFGQVVKAHDVKENKFVALKVIRNRKRFH---AQALVEVKILKHLKdndkegKHHCIEMVAYFTFRQHLCIAFELLSIN-LYEFIKnNN 591
                 678889****************************98887...558**********9877777789**********************88.888888444 PP

                 SS.--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE..TTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHH CS
     Pkinase  93 gs.lseeeakkiakqilegleylHskgiiHrDlKpeNiLid..ekgelKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvily 188
                    ls + ++k+a qil++l+yl +++iiH+DlKpeNiL+   +k ++K++DFG ++  +++    +++ ++ Y++PE++ + +y++++D+Ws G+il+
  EFC36361.1 592 FRgLSLALIRKFALQILNSLQYLSQEKIIHCDLKPENILLVssTKSDIKMIDFGSSCFENER--IYTYIQSRFYRSPEIILGISYGRSIDMWSFGCILA 688
                 447************************************99534555*********988875..69********************************* PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHHTTS.....................................-HHHHHHHHHHT- CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasei.....................................seeakdllkkllk 246
                 el+tg p+f+g++       el+ql  i++++g    +  + +                                           ++++ ++++ +l+
  EFC36361.1 689 ELYTGYPLFPGRN-------ELEQLCYIMEVMGmpskKLIQIST----RrkkffdsngqprlvinkktgkkripgsvtlqqaldcpDRKFVSFMEACLR 776
                 **********444.......566666666677654322222222....12334777889999************************************* PP

                 SSGCCSTTHHHHHTSGGG CS
     Pkinase 247 kdpkkRltaeellqhpyl 264
                 +dp +R+t ee+ +h+++
  EFC36361.1 777 WDPVERMTPEEAFRHEWI 794
                 *****************7 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.8   0.3   1.1e-26   4.8e-23       7     219 ..     503     710 ..     498     790 .. 0.84

  Alignments for each domain:
  == domain 1  score: 81.8 bits;  conditional E-value: 1.1e-26
                  EEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-.....BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTT CS
  Pkinase_Tyr   7 lGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.k.....hpnivkllgvctkeepllivteyvkgGdLlkfLrkkeke 98 
                  lG+G+fG+Vv+++      k++  Va+K+++++++   +++ l e+ki+k+l +     +++ +++++  t +++l+i +e+++  +L +f+++++ +
   EFC36361.1 503 LGKGSFGQVVKAHDV----KENKFVALKVIRNRKRF--HAQALVEVKILKHLkDndkegKHHCIEMVAYFTFRQHLCIAFELLSI-NLYEFIKNNNFR 593
                  9***********998....78899******765555..5888899*****995433333369********************987.8*********** PP

                  TSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE..TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHH CS
  Pkinase_Tyr  99 kltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse..nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvl 194
                   l+l  + +falq+ + ++yL+++k++H dl   N+Ll +  ++ +k+ DfG +    ++  y+       +  + +pE++   ++  + D+WsfG +
   EFC36361.1 594 GLSLALIRKFALQILNSLQYLSQEKIIHCDLKPENILLVSstKSDIKMIDFGSSCFE-NERIYTYI----QSRFYRSPEIILGISYGRSIDMWSFGCI 686
                  ************************************997634669*******87765.44434322....234588********************** PP

                  HHHHHTTSSGTTTTSHHHHHHHHHH CS
  Pkinase_Tyr 195 lwEiftlgespypglkneevleklk 219
                  l E++t g   +pg ++ e l ++ 
   EFC36361.1 687 LAELYT-GYPLFPGRNELEQLCYIM 710
                  *****9.877777765555554444 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.9   0.0    0.0046        21      23      74 ..     523     579 ..     500     581 .. 0.85
   2 !   11.0   0.0   6.8e-05       0.3     156     196 ..     603     647 ..     590     650 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0046
                 EEEEEE-TT.S-HHHHHHHHHHHHHHHHTT-....B--B-CTTBS-EEETTEEEEEE CS
         APH  23 yvlrrnppa.raaeeirrevallrlLakagv....pvPevlagdtddeeigllfali 74 
                 ++l++++ + r ++++  ev++l++L ++++    ++ e++a+ t ++++ + f+l+
  EFC36361.1 523 VALKVIRNRkRFHAQALVEVKILKHLKDNDKegkhHCIEMVAYFTFRQHLCIAFELL 579
                 45899888889******************9999999**************9999987 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 6.8e-05
                 HHHH--S....SS-EEEE-SS-SGGGEEEC...TTEEEEE---TT- CS
         APH 156 laallpg....elptvllHgDlhpgNllvd.pddgrvtGviDfeda 196
                 +a   ++     +++ ++H+Dl+p N+l+  ++    + +iDf+ +
  EFC36361.1 603 FALQILNslqyLSQEKIIHCDLKPENILLVsST-KSDIKMIDFGSS 647
                 4444444455578899*************9633.333369999976 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   1.7   6.9e-06     0.031      60     176 ..     515     649 ..     507     656 .. 0.58
   2 ?    0.2   0.0      0.11   4.8e+02      42      57 ..     648     663 ..     645     669 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 6.9e-06
                     TGGGCHHHHH.HHHHHHHHHTTCHH...........TTSSSS-HHHHHHHHH........HHCCS.TT..ECHHGGCCHCCCTHHHHHHHHHTHH CS
  Choline_kinase  60 edlrepeisk.kiAkklaelHslel..........eseskespslwktmqkw........llnkeaqtkakkekkkkqlklinledlekelekle 135
                     +d++e+++ + k+ ++ +++H+ +l          +   ke +  + +m  +        +  +   ++  +  k+++++ ++l+ ++k + ++ 
      EFC36361.1 515 HDVKENKFVAlKVIRNRKRFHAQALvevkilkhlkD-NDKEGKHHCIEMVAYftfrqhlcIAFELLSINLYEFIKNNNFRGLSLALIRKFALQIL 608
                     566665554425666666666666666666666632.3333333333333333444334444444444445555555555666666666666666 PP

                     HHHHCHGG-EEEE-S--SGGGEEE..-CTTEEEE--GTT-EE CS
  Choline_kinase 136 klleelespvvfcHnDlqegNill.nkeekklvlIDFEYagy 176
                     + l++l ++ +  H+Dl ++Nill +++++++ +IDF  +++
      EFC36361.1 609 NSLQYLSQE-KIIHCDLKPENILLvSSTKSDIKMIDFGSSCF 649
                     666554444.456*********98678899*******77665 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.11
                     EETTEEEEE--TCEE- CS
  Choline_kinase  42 ifenGrieefiesrtl 57 
                     +fen ri+ +i+sr  
      EFC36361.1 648 CFENERIYTYIQSRFY 663
                     8************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (802 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       940  (0.052429); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.77u 0.38s 00:00:01.14 Elapsed: 00:00:00.56
# Mc/sec: 4309.86
//
Query:       EFC36362.1  [L=156]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00068   19.3   0.1      0.053   13.2   0.1    2.4  2  Dpy-30     Dpy-30 motif
  ------ inclusion threshold ------
      0.058   13.9   3.1       0.15   12.6   3.0    1.7  1  FeoB_Cyto  FeoB cytosolic helical domain


Domain annotation for each model (and alignments):
>> Dpy-30  Dpy-30 motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.8   0.0    0.0051        46       3      21 ..      39      57 ..      37      60 .. 0.83
   2 !   13.2   0.1   5.9e-06     0.053      28      42 .]      86     100 ..      85     100 .. 0.94

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.0051
                HHHHHHHTHHHHHHHHHHH CS
      Dpy-30  3 rkYLnktvaPiLlqGLtel 21
                ++YL+++++ +L+ + + l
  EFC36362.1 39 SFYLEENILGVLIPAFQSL 57
                78**********9988766 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 5.9e-06
                 SHHHHHHHHHHHHGG CS
      Dpy-30  28 DPieyLAeYLlknkn 42 
                 DPi ++A YL++n++
  EFC36362.1  86 DPINWIAMYLIRNNP 100
                 9************96 PP

>> FeoB_Cyto  FeoB cytosolic helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   3.0   1.6e-05      0.15       8      84 ..      73     148 ..      67     155 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.6e-05
   FeoB_Cyto   8 aiekleellkesnlkaklppRwlAlklLegDeelleelkedp...elraeveearkeleaelgedledvIvdarykfieg 84 
                 + ekl++ + ++      p  w+A+ l+ ++++  + l+++p    l++ +e++r e+ ++++ + e+ I +++ +++++
  EFC36362.1  73 EYEKLKSTIYSK----IDPINWIAMYLIRNNPKHSKNLENNPyskLLKEHIEKIRPEIMKNREGKSESQIKQEIKDMAKE 148
                 555555555543....55678******************97544477889999999999998887777777777666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1352  (0.0754086); expected 358.6 (0.02)
Passed bias filter:                      589  (0.0328518); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 935.29
//
Query:       EFC36363.1  [L=268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.018   14.7   0.0      0.063   13.0   0.0    1.9  2  DotU        Type VI secretion system protein DotU
      0.046   13.9   1.4      0.096   12.9   1.4    1.5  1  CID_GANP    Binding region of GANP to ENY2
      0.047   12.4   0.0      0.079   11.7   0.0    1.3  1  DUF2207     Predicted membrane protein (DUF2207)


Domain annotation for each model (and alignments):
>> DotU  Type VI secretion system protein DotU
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.28   1.7e+03      24      54 ..      36      66 ..      28      71 .. 0.83
   2 ?   13.0   0.0   1.1e-05     0.063     157     203 ..     192     238 ..     160     240 .. 0.66

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.28
        DotU 24 dvealrerlveelrafeqrlkaagysaedie 54
                +v +lrer  +++ ++ ++ ++++++++ + 
  EFC36363.1 36 EVSDLRERSLNLIYEVSEEKRKLRFKKDAVM 66
                5788999999999999999999998888775 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 1.1e-05
        DotU 157 geaeea.lsphwqagdeaarrllrrelplwvilalallvllllflgls 203
                 +++ee+ +++++  ++++  ++ r+++p+wv++++all++++ f+ ls
  EFC36363.1 192 EKKEEKpIETRKI-PAAQVPKPPREKVPFWVFVIVALLLAVCGFCCLS 238
                 3333332444443.444455555779***************9999887 PP

>> CID_GANP  Binding region of GANP to ENY2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   1.4   1.6e-05     0.096      20      42 ..     167     189 ..     156     191 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.6e-05
    CID_GANP  20 ecvretasaElksAvetdkaarv 42 
                 e v+eta++E++ A e+dk++ +
  EFC36363.1 167 ETVEETAEEEIRTAEEEDKKINI 189
                 89*****************9977 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   1.3e-05     0.079     140     244 ..     136     254 ..     117     263 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.3e-05
     DUF2207 140 g......ldgsttvkkddgsvtftarnlppgeglevrvlf..ptnnarktsgnkldeilkeeqk..........ntreraarlslallillilllilll 220
                         +++ tv++d+++ +++   l+ +e +e  +         + + ++k+ +i++e ++          +++ ++  + ++ +++++++++ll+
  EFC36363.1 136 SgkgfvpISKKDTVDEDTNNKEINDLGLEDDETVEETAEEeiR----TAEEEDKKINIIEEKKEekpietrkipAAQVPKPPREKVPFWVFVIVALLLA 230
                 3455555444444444444444444444444444444444221....2222333333333333366777779997788888888888888899999999 PP

     DUF2207 221 llllllliklllwkkygrepkvke 244
                 ++ +++l  +l+ ++ gr++++ +
  EFC36363.1 231 VCGFCCLSLTLMVRRRGRKDRPSV 254
                 9999999999999999***99977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1622  (0.090468); expected 358.6 (0.02)
Passed bias filter:                      985  (0.0549389); expected 358.6 (0.02)
Passed Vit filter:                       102  (0.00568911); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1735.44
//
Query:       EFC36364.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.13   12.8   1.8       0.18   12.3   1.8    1.2  1  LPAM_1          Prokaryotic membrane lipoprotein lipid attach


Domain annotation for each model (and alignments):
>> LPAM_1  Prokaryotic membrane lipoprotein lipid attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.8     1e-05      0.18       1      17 [.       1      17 [.       1      17 [. 0.96

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1e-05
      LPAM_1  1 MKKillalgalllLsGC 17
                M K++ al+a+llL+ C
  EFC36364.1  1 MNKFIAALVATLLLATC 17
                9*************988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 933.14
//
Query:       EFC36365.1  [L=160]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-05   24.9  98.0       0.07   13.1  36.6    3.0  2  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1  36.6   3.9e-06      0.07      59     111 ..       2      54 ..       1      54 [. 0.54
   2 ?  -18.7  74.9         1   1.8e+04      65      77 ..      74      86 ..      30     135 .. 0.46

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.9e-06
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC36365.1   2 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 54 
                  45555555555555555555555555555555556655666666666666555 PP

  == domain 2  score: -18.7 bits;  conditional E-value: 1
  Trypan_PARP 65 pepepepepepep 77
                 p+p+p+p+p+p+p
   EFC36365.1 74 PKPKPKPKPKPKP 86
                 0000000000000 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       258  (0.0143901); expected 358.6 (0.02)
Passed bias filter:                      125  (0.00697194); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.34s 00:00:01.14 Elapsed: 00:00:00.51
# Mc/sec: 946.38
//
Query:       EFC36366.1  [L=518]
Description: hypothetical protein NAEGRDRAFT_75899 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.8e-05   22.7  37.8     0.0023   18.3   1.4    8.0  6  LRR_4         Leucine Rich repeats (2 copies)
    0.00097   19.0   0.0     0.0034   17.2   0.0    1.9  1  F-box         F-box domain
  ------ inclusion threshold ------
      0.048   13.6   0.2         14    5.7   0.0    2.6  2  Flavi_propep  Flavivirus polyprotein propeptide
      0.053   13.3  18.2      0.063   13.0   2.3    6.0  6  LRR_8         Leucine rich repeat
      0.073   13.2   0.1        9.1    6.5   0.0    2.6  2  Ntox34        Bacterial toxin 34


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   2.4     0.003        11      17      37 ..     172     191 ..     130     194 .. 0.85
   2 !   18.3   1.4   6.3e-07    0.0023       2      37 ..     179     215 ..     178     222 .. 0.80
   3 ?    0.5   1.6      0.25   9.1e+02       7      30 ..     245     268 ..     220     280 .. 0.65
   4 !   11.6   1.7     8e-05      0.29       1      29 [.     317     350 ..     302     359 .. 0.85
   5 !   10.0   0.0   0.00026      0.94       2      28 ..     373     400 ..     372     407 .. 0.90
   6 ?   -2.1   5.1       1.7   5.9e+03      22      30 ..     448     456 ..     416     484 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.003
                 S-HHH-TT--EEE-.-S---- CS
       LRR_4  17 plleklpnLkeLdLsgNnlit 37 
                 +++++l++L +LdLs+N +++
  EFC36366.1 172 SNCRNLDKLNSLDLSSN-KLE 191
                 4566899999999*998.654 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 6.3e-07
                 S--EEE--SS---E-S-..HH..H-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..le..klpnLkeLdLsgNnlit 37 
                 +L +LdLs+N+l + +   l    +pnL+eL+L    +i+
  EFC36366.1 179 KLNSLDLSSNKLEKASIdhLIkcHMPNLTELNLA---YIK 215
                 7999*********99997733666*********3...354 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.25
                 E--SS---E-S-HHH-TT--EEE- CS
       LRR_4   7 dLsnNqltdiplleklpnLkeLdL 30 
                 ++s N   +i+  + l + ++L +
  EFC36366.1 245 NCSKNLFASISQSKILNQITHLKI 268
                 456666666666444555555555 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 8e-05
                 SS--EEE--SS---E-S-..HH...H-TT--EEE CS
       LRR_4   1 pnLevLdLsnNqltdipl..le...klpnLkeLd 29 
                 +nL++Ld+ +++++   +  l    +lpnL++L+
  EFC36366.1 317 KNLTSLDICSCKIRNQVFadLIvspNLPNLTSLN 350
                 79************777766226667*******8 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00026
                 S--EEE--SS---E-S-HHH.-TT--EE CS
       LRR_4   2 nLevLdLsnNqltdipllek.lpnLkeL 28 
                 +L+ LdL+n ++ ++p l   +p+Lk+L
  EFC36366.1 373 SLTDLDLGNFRVASFPKLVDhCPKLKKL 400
                 79******99*******9966*****99 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 1.7
                 -TT--EEE- CS
       LRR_4  22 lpnLkeLdL 30 
                 l nLkeL+L
  EFC36366.1 448 LSNLKELHL 456
                 666666665 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   9.6e-07    0.0034       7      44 ..     100     138 ..      95     141 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 9.6e-07
                 -HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHHHH CS
       F-box   7 PsevlrhILerLplsd.llalrrVSkgwrilidsdrlwc 44 
                  s+vl +I ++L++s+ +  + +VSk w++ +++++l+ 
  EFC36366.1 100 NSDVLSEIYQFLDTSTvIHGCGLVSKLWNQSLKGLKLKV 138
                 689********************************9985 PP

>> Flavi_propep  Flavivirus polyprotein propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.2    0.0074        26      32      62 ..      30      61 ..      23      69 .. 0.88
   2 ?    5.7   0.0    0.0039        14      46      69 ..     419     442 ..     412     449 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0074
  Flavi_propep 32 iilelkelcedsmeykcprls.eeepddvdcw 62
                  +i++  +l e+ me +c  +s  ++   vdc 
    EFC36366.1 30 KIMDESDLFEELMEVNCKLISlAKKAKVVDCR 61
                  699******************88899999995 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0039
  Flavi_propep  46 ykcprlseeepddvdcwcyavevr 69 
                    k p+ls+ e  d+ cw  + e+ 
    EFC36366.1 419 MKSPNLSNVEYLDILCWNETSEII 442
                   489**************9999965 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   2.3   1.8e-05     0.063      22      57 ..     175     212 ..     154     213 .. 0.85
   2 ?   -0.9   0.2      0.39   1.4e+03      24      50 ..     231     256 ..     228     269 .. 0.71
   3 ?    1.8   0.1     0.059   2.1e+02       2      15 ..     318     331 ..     317     353 .. 0.60
   4 ?    4.2   0.0      0.01        36      25      54 ..     372     400 ..     367     402 .. 0.92
   5 ?   -3.6   0.0       2.7   9.7e+03      23      32 ..     423     432 ..     423     432 .. 0.71
   6 ?    0.1   0.0      0.19   6.8e+02      24      33 ..     448     457 ..     438     458 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.8e-05
                 TT-TT--EEE--SS---GGGGGGG..TT--S-.EEE-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgaf..sgLpsLrsLdLs 57 
                 ++l +L++LdLs+N+l+  s + +   ++p+L++L+L 
  EFC36366.1 175 RNLDKLNSLDLSSNKLEKASIDHLikCHMPNLTELNLA 212
                 5899999*******999977777734589999999996 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.39
                 -TT--EEE--SS---GGGGGGGTT--S CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLps 50 
                 +++ k LdL +  l+  s++ f++ ++
  EFC36366.1 231 MKSIKKLDLCES-LENCSKNLFASISQ 256
                 677888888877.66666777766655 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.059
                 T-SEEE-TTS--SE CS
       LRR_8   2 nLtsLdLsnNrlts 15 
                 nLtsLd+++ ++ +
  EFC36366.1 318 NLTSLDICSCKIRN 331
                 78888888888643 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.01
                 TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8  25 snLkvLdLsnNllttlspgafsgLpsLrsL 54 
                 s+L+ LdL+n +  ++ p+  +++p+L++L
  EFC36366.1 372 SSLTDLDLGNFRVASF-PKLVDHCPKLKKL 400
                 79**************.9*********998 PP

  == domain 5  score: -3.6 bits;  conditional E-value: 2.7
                 T-TT--EEE- CS
       LRR_8  23 glsnLkvLdL 32 
                 +lsn+++Ld+
  EFC36366.1 423 NLSNVEYLDI 432
                 5788888875 PP

  == domain 6  score: 0.1 bits;  conditional E-value: 0.19
                 -TT--EEE-- CS
       LRR_8  24 lsnLkvLdLs 33 
                 lsnLk+L+Ls
  EFC36366.1 448 LSNLKELHLS 457
                 7888888887 PP

>> Ntox34  Bacterial toxin 34
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0    0.0025       9.1      30      62 ..      22      54 ..      17      63 .. 0.75
   2 ?    3.7   0.0     0.018        66      27      48 ..     224     245 ..     218     252 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0025
      Ntox34 30 ndrfwsdGkkadiCdvldelieaarraGdiskk 62
                +d f +dGk  d  d ++el+e   +   ++kk
  EFC36366.1 22 DDEFCEDGKIMDESDLFEELMEVNCKLISLAKK 54
                589*******************55444333333 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.018
      Ntox34  27 dlindrfwsdGkkadiCdvlde 48 
                 +l+n rf +  kk d C+ l++
  EFC36366.1 224 ELLNSRFMKSIKKLDLCESLEN 245
                 689***************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (518 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       874  (0.0487478); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 3570.34
//
Query:       EFC36367.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.3e-20   72.6   1.0    7.2e-16   58.6   0.1    2.2  2  Glyoxalase    Glyoxalase/Bleomycin resistance protein/Dioxyge
    4.4e-10   39.8   0.1    0.00016   21.9   0.0    2.5  2  Glyoxalase_4  Glyoxalase/Bleomycin resistance protein/Dioxyge
    1.4e-06   28.5   0.9    6.6e-06   26.3   0.4    2.2  2  Glyoxalase_5  Hydroxyphenylpyruvate dioxygenase, HPPD, N-term
    2.1e-05   24.7   0.0       0.11   12.6   0.0    2.9  2  Glyoxalase_3  Glyoxalase-like domain


Domain annotation for each model (and alignments):
>> Glyoxalase  Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.1     2e-05     0.089       2     106 ..      14     122 ..      13     148 .. 0.84
   2 !   58.6   0.1   1.6e-19   7.2e-16       7     128 .]     190     337 ..     182     337 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2e-05
                 EEEEEEEESHHHHHHHHHHHHHTSEEEEEEEEEESTEEEEEEEEETTTSEEEEEEEECCTTSCTHHCCBS.C...TSEEEEEEEEEHCHHHHHHHHHHH CS
  Glyoxalase   2 idhvallvgdleksldFYtkvLGfklvkktdnteeteglriaffhaggghielvlneapsgaakhvkkie.e...tvhhvafialdvedvgkaldrlke 96 
                 +d+v   vg++ ++ d+Y   +Gfk    ++ +++ + l  ++++ +++ +++ +   p ++ +  k++  +   ++ +v  ia++v++ ++ ++ + e
  EFC36367.1  14 FDYVEFWVGNAVQARDYYISRFGFKPYAFKGLETGSKELVTHVIRQNNTILAFSSPLLPASKSAIAKEMTaHhaeHGDGVKDIAFTVDNAEAIYKAAVE 112
                 5899999************************76666888999999999998888888888888877663333578999*******************99 PP

                 TTGEEEEEEE CS
  Glyoxalase  97 agvkvvaepg 106
                 +g   v+ep+
  EFC36367.1 113 NGAISVREPT 122
                 9976666664 PP

  == domain 2  score: 58.6 bits;  conditional E-value: 1.6e-19
                 EEESHHHHHHHHHHHHHTSEEEEEEEE...EESTEEEEEEEEETTTSEEEEEEEECCTTSCTHHCCBS.C..TSEEEEEEEEEHCHHHHHHHHHHHTTG CS
  Glyoxalase   7 llvgdleksldFYtkvLGfklvkktdn...teeteglriaffhaggghielvlneapsgaakhvkkie.e..tvhhvafialdvedvgkaldrlkeagv 99 
                 +  g++   +d+Y++ LGf+ ++ +d+   ++e + l ++++ +++  +++++ne+++g++ ++ + + +  ++++ ++ial +ed+++++ +++++gv
  EFC36367.1 190 QGWGEMTPVCDWYEQKLGFHKFWSVDDsvmHTEFSALSSTVMADSEENVKMPINEPAKGKKMSQIEEFvNfyGGAGAQHIALRTEDIIHTVTQMRARGV 288
                 5557788889*****************9988888******************************665555889************************** PP

                 EEEEEEECHHCTEEEEE....................EEEETTSEEEEE CS
  Glyoxalase 100 kvvaepgrhyfgalysf....................yfrDpdGillei 128
                  + ++p+ +y + +                       + +D +G+ll+i
  EFC36367.1 289 AFLPTPDSYYDNLRKRLahapitvkedidvlqklkilVDFDDKGYLLQI 337
                 **************98899999999999999999999999999999986 PP

>> Glyoxalase_4  Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0     4e-06     0.018       3      92 ..      17     116 ..      15     126 .. 0.71
   2 !   21.9   0.0   3.6e-08   0.00016      15      97 ..     200     294 ..     195     303 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 4e-06
                   EEEE-S-HHHHHHHHHH.TT-EES..S--E.EETTTTEEEEEEEETTEEEEEEEESSTT..........-THHHTS-EEEEEEEEES-HHHHHHHHC CS
  Glyoxalase_4   3 igivVeDleaavarfsallGvgpw..qryrdepqevdlafallgsgsvqieLieplegp..........eflaehgeglhhlaywvddldaavarle 87 
                   ++++V +  +a +++   +G++p   +  +  ++e  +++ + +++   + + +pl  +           ++aehg g+  +a+ vd+ +a+ +++ 
    EFC36367.1  17 VEFWVGNAVQARDYYISRFGFKPYafKGLETGSKELVTHVIRQNNT--ILAFSSPLLPAsksaiakemtAHHAEHGDGVKDIAFTVDNAEAIYKAAV 111
                   6789999999999999999998873223333444444555555553..45666665544444555555588888*********************** PP

                   TTTEE CS
  Glyoxalase_4  88 eqGfe 92 
                   e+G+ 
    EFC36367.1 112 ENGAI 116
                   *9986 PP

  == domain 2  score: 21.9 bits;  conditional E-value: 3.6e-08
                   HHHHH.TT-EESS--E.EET.....TTTEEEEEEEETTEEEEEEEESSTT..-THHH.....TS-EEEEEEEEES-HHHHHHHHCTTTEEEEEEE CS
  Glyoxalase_4  15 arfsallGvgpwqryrdepq.....evdlafallgsgsvqieLieplegp..eflae.....hgeglhhlaywvddldaavarleeqGfevvqkg 97 
                   + +++ lG+++++ + d          +  ++  ++++v+    ep +g+  + ++e     +g+g +h+a++++d+ ++v +++++G+++++  
    EFC36367.1 200 DWYEQKLGFHKFWSVDDSVMhtefsALSSTVMADSEENVKMPINEPAKGKkmSQIEEfvnfyGGAGAQHIALRTEDIIHTVTQMRARGVAFLPTP 294
                   5678888888777766544311111334444444455688888899999988666667778*****************************99765 PP

>> Glyoxalase_5  Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.4   1.5e-09   6.6e-06       9     128 ..      13     151 ..       5     158 .. 0.65
   2 ?   -0.7   0.0      0.33   1.5e+03      57      90 ..     248     282 ..     206     294 .. 0.67

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 1.5e-09
  Glyoxalase_5   9 Gfefvefaapea.ealeelfeklGftava....rhrskdv..tlyrqGginf.....ilneepdsaaakfa...rehGpsacalafrvkdakkayer 90 
                    f++vef   +a +a + + +++Gf+  a    +  sk++  ++ rq +  +     +l + +++ a++++   +ehG ++  +af v +a+++y+ 
    EFC36367.1  13 AFDYVEFWVGNAvQARDYYISRFGFKPYAfkglETGSKELvtHVIRQNNTILafsspLLPASKSAIAKEMTahhAEHGDGVKDIAFTVDNAEAIYKA 109
                   57777777666514444455677777655222223345431246677665432233344555555555544112689******************** PP

  Glyoxalase_5  91 alekGakpveket....gvmelkiPaikGiGgsllylvdrye 128
                   a+e+Ga +v+++t    +   +ki +++  G+++  +v+r e
    EFC36367.1 110 AVENGAISVREPTvltdELGSVKIASVRTYGETIHTFVERAE 151
                   *******9998862222445799***********99999965 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.33
  Glyoxalase_5  57 eepdsaaakfarehG.psacalafrvkdakkayer 90 
                    ++ s++++f + +G ++a  +a+r +d  ++ ++
    EFC36367.1 248 GKKMSQIEEFVNFYGgAGAQHIALRTEDIIHTVTQ 282
                   45677888888776515677888888886655554 PP

>> Glyoxalase_3  Glyoxalase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.0   0.00031       1.4      63     106 ..      78     121 ..      17     151 .. 0.79
   2 !   12.6   0.0   2.4e-05      0.11      61     102 ..     246     293 ..     183     316 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00031
  Glyoxalase_3  63 rprlfgldrlakgeglhtlalrtddidataarlraaGvdeagrr 106
                    ++ + ++++++g+g++++a+++d+++a ++++ ++G  +  ++
    EFC36367.1  78 IAKEMTAHHAEHGDGVKDIAFTVDNAEAIYKAAVENGAISVREP 121
                   34445567889**********************99995433333 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 2.4e-05
  Glyoxalase_3  61 perprlfgld...rlakgeglhtlalrtddidataarlraaGvd...e 102
                   ++ +++ +++    +  g g+ ++alrt+di  t+ ++ra+Gv+   +
    EFC36367.1 246 AKGKKMSQIEefvNFYGGAGAQHIALRTEDIIHTVTQMRARGVAflpT 293
                   33334444443336668*************************975441 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       455  (0.0253779); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.43
# Mc/sec: 2715.74
//
Query:       EFC36368.1  [L=507]
Description: hypothetical protein NAEGRDRAFT_75901 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.1e-07   29.4  42.0      0.024   15.1   0.6    9.0  9  LRR_4     Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
        0.3   11.2   2.7       0.33   11.1   0.5    2.4  2  VirE1     Single-strand DNA-binding protein
        4.7    7.5  22.8        1.9    8.8   0.1    7.9 10  LRR_6     Leucine Rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.1   6.3e+03      21      30 ..      73      83 ..      46      87 .. 0.63
   2 !    7.1   0.8    0.0012       7.4      19      33 ..     169     183 ..     146     193 .. 0.77
   3 !    9.0   2.5   0.00032       1.9       1      33 [.     197     234 ..     197     274 .. 0.81
   4 !   10.6   0.5    0.0001      0.61       2      36 ..     280     316 ..     279     320 .. 0.79
   5 !   15.1   0.6     4e-06     0.024       2      28 ..     305     337 ..     305     338 .. 0.85
   6 !   10.7   0.0   9.8e-05      0.58       2      30 ..     364     393 ..     363     399 .. 0.89
   7 ?    3.3   1.2     0.021   1.2e+02      14      32 ..     410     424 ..     402     444 .. 0.73
   8 ?   -1.2   0.4      0.54   3.2e+03      24      30 ..     440     446 ..     432     460 .. 0.79
   9 ?    0.5   4.3      0.15   9.1e+02       2      31 ..     440     476 ..     439     487 .. 0.62

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.1
                H.-TT--EEE- CS
       LRR_4 21 k.lpnLkeLdL 30
                + +  Lk+Ld+
  EFC36368.1 73 NiNEFLKQLDM 83
                32333777776 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0012
                 HHH-TT--EEE-.-S CS
       LRR_4  19 leklpnLkeLdLsgN 33 
                 +++l+nLk+LdLs+ 
  EFC36368.1 169 CRNLDNLKSLDLSEI 183
                 458*********764 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00032
                 SS--EEE--SS---E-S-.HH....H.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl.le....k.lpnLkeLdLsgN 33 
                 pnL++L+L+  +++d +  +e    + +++ k+LdLs  
  EFC36368.1 197 PNLTELNLAK-RVSDEEVvIElltsSfMTSVKKLDLSYS 234
                 8********8.***9999833456888*********763 PP

  == domain 4  score: 10.6 bits;  conditional E-value: 0.0001
                 S--EEE--.SS---E-S-.HH..H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLs.nNqltdipl.le..klpnLkeLdLsgNnli 36 
                 nLe+L ++ ++ ++  p+ +   +  nL++Ld+s++ ++
  EFC36368.1 280 NLEHLQIRkHCLVS-YPNlFTngNYMNLTYLDISSC-QL 316
                 9*******996666.777655766*********999.55 PP

  == domain 5  score: 15.1 bits;  conditional E-value: 4e-06
                 S--EEE--SS---E-S-HH......H-TT--EE CS
       LRR_4   2 nLevLdLsnNqltdiplle......klpnLkeL 28 
                 nL++Ld+s++ql+  + +       +lpnL++L
  EFC36368.1 305 NLTYLDISSCQLSRNQEFIdlmfspNLPNLTTL 337
                 9************8888444666678******9 PP

  == domain 6  score: 10.7 bits;  conditional E-value: 9.8e-05
                 S--EEE--SS---E-S-.HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpnLkeLdL 30 
                 +L+ Ld++ +++   p+ ++ +p+Lk+L++
  EFC36368.1 364 SLTDLDIRYCRVGFYPSlFNHCPKLKKLSV 393
                 79***************7777*******97 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.021
                 -E-S-HHH-TT--EEE-.- CS
       LRR_4  14 tdiplleklpnLkeLdLsg 32 
                 ++   ++ l+nL++L + +
  EFC36368.1 410 KS---PN-LTNLEYLKMDS 424
                 43...66.*******9944 PP

  == domain 8  score: -1.2 bits;  conditional E-value: 0.54
                 T--EEE- CS
       LRR_4  24 nLkeLdL 30 
                 nLkeL+L
  EFC36368.1 440 NLKELHL 446
                 6777776 PP

  == domain 9  score: 0.5 bits;  conditional E-value: 0.15
                 S--EEE--S......S.---E-S-HHH-TT--EEE-. CS
       LRR_4   2 nLevLdLsn......N.qltdiplleklpnLkeLdLs 31 
                 nL++L+L        N ++  ++++++l nL++L++s
  EFC36368.1 440 NLKELHLVRpfrngeNlNVELVSNCNNLVNLTTLTVS 476
                 56666666444434444455555688999****9983 PP

>> VirE1  Single-strand DNA-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.5   5.5e-05      0.33      35      58 ..     173     198 ..     146     206 .. 0.72
   2 ?   -2.4   0.1      0.93   5.5e+03      36      42 ..     267     273 ..     242     285 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.5e-05
                 TTS-HHHHHHHHHHH..HHHT----- CS
       VirE1  35 nGftsLDLemieLen..fvLrCPLPe 58 
                 +   sLDL  ieLen  + ++C +P+
  EFC36368.1 173 DNLKSLDLSEIELENveYLMKCHMPN 198
                 5578**********966799**9884 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.93
                 TS-HHHH CS
       VirE1  36 GftsLDL 42 
                  ft LDL
  EFC36368.1 267 EFTGLDL 273
                 3555555 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       2.4   1.4e+04       2      11 ..      75      84 ..      75      84 .. 0.80
   2 ?    0.8   0.1      0.11   6.8e+02       4      11 ..     174     181 ..     173     182 .. 0.91
   3 ?    1.8   0.1     0.052   3.1e+02       2      11 ..     196     205 ..     195     206 .. 0.85
   4 ?    0.5   0.0      0.14   8.3e+02       3      12 ..     224     233 ..     223     234 .. 0.87
   5 ?   -3.7   0.1         3   1.8e+04       5      10 ..     255     260 ..     253     261 .. 0.78
   6 ?   -2.5   0.1       1.3   7.5e+03       4      14 ..     280     290 ..     279     291 .. 0.78
   7 ?    8.8   0.1   0.00032       1.9       3      15 ..     304     316 ..     304     317 .. 0.90
   8 ?    5.0   0.0     0.005        30       3      16 ..     363     376 ..     361     376 .. 0.88
   9 ?   -1.4   0.0      0.59   3.5e+03       1      10 [.     384     393 ..     384     393 .. 0.88
  10 ?   -2.1   0.1      0.99   5.9e+03       3      10 ..     439     446 ..     439     447 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.4
       LRR_6  2 nthLteLdLs 11
                n  L+ Ld++
  EFC36368.1 75 NEFLKQLDMR 84
                6679****85 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.11
       LRR_6   4 hLteLdLs 11 
                 +L++LdLs
  EFC36368.1 174 NLKSLDLS 181
                 69*****9 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.052
       LRR_6   2 nthLteLdLs 11 
                  ++LteL+L+
  EFC36368.1 196 MPNLTELNLA 205
                 689*****96 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.14
       LRR_6   3 thLteLdLsg 12 
                 t++++LdLs+
  EFC36368.1 224 TSVKKLDLSY 233
                 789*****97 PP

  == domain 5  score: -3.7 bits;  conditional E-value: 3
       LRR_6   5 LteLdL 10 
                 +t+L+L
  EFC36368.1 255 ITHLNL 260
                 689998 PP

  == domain 6  score: -2.5 bits;  conditional E-value: 1.3
       LRR_6   4 hLteLdLsgNd 14 
                 +L++L+++ ++
  EFC36368.1 280 NLEHLQIRKHC 290
                 69999998766 PP

  == domain 7  score: 8.8 bits;  conditional E-value: 0.00032
       LRR_6   3 thLteLdLsgNdI 15 
                 ++Lt+Ld+s++++
  EFC36368.1 304 MNLTYLDISSCQL 316
                 58*********98 PP

  == domain 8  score: 5.0 bits;  conditional E-value: 0.005
       LRR_6   3 thLteLdLsgNdIg 16 
                 ++Lt Ld++++ +g
  EFC36368.1 363 SSLTDLDIRYCRVG 376
                 79*********986 PP

  == domain 9  score: -1.4 bits;  conditional E-value: 0.59
       LRR_6   1 snthLteLdL 10 
                 ++++L++L++
  EFC36368.1 384 HCPKLKKLSV 393
                 79*****986 PP

  == domain 10  score: -2.1 bits;  conditional E-value: 0.99
       LRR_6   3 thLteLdL 10 
                 ++L+eL+L
  EFC36368.1 439 SNLKELHL 446
                 68****98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       867  (0.0483574); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 3061.17
//
Query:       EFC36369.1  [L=671]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (671 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1014  (0.0565564); expected 358.6 (0.02)
Passed bias filter:                      625  (0.0348597); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.50
# Mc/sec: 4071.62
//
Query:       EFC36370.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-41  136.5   8.5      9e-06   25.4   0.0    8.5  8  LRR_6     Leucine Rich repeat
    1.8e-20   72.4   8.3    2.2e-06   27.3   0.5    4.4  4  LRR_8     Leucine rich repeat
      8e-16   57.9  14.7     0.0033   17.8   0.0    6.1  9  LRR_4     Leucine Rich repeats (2 copies)
    9.6e-14   49.8   0.3        1.5    9.7   0.0    8.4  8  LRR_1     Leucine Rich Repeat
    0.00016   21.2   0.9       0.13   11.7   0.1    2.9  3  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
      0.052   14.3   2.0        3.5    8.4   0.1    2.7  3  PulA_N1   Pullulanase N1-terminal domain
      0.072   12.9   0.0        6.7    6.6   0.0    3.2  3  PapC_C    PapC C-terminal domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   0.00021      0.54       5      24 .]      34      53 ..      32      53 .. 0.92
   2 !   13.1   0.1     3e-05     0.076       5      24 .]      82     101 ..      79     101 .. 0.92
   3 !   12.4   0.0     5e-05      0.13       5      24 .]     106     125 ..     103     125 .. 0.93
   4 !   18.9   0.0     4e-07     0.001       5      24 .]     130     149 ..     127     149 .. 0.92
   5 !   19.3   0.0   3.1e-07   0.00079       3      19 ..     152     168 ..     150     173 .. 0.87
   6 !   16.3   0.1   2.9e-06    0.0074       4      24 .]     177     197 ..     174     197 .. 0.91
   7 !   17.4   0.0   1.2e-06    0.0032       4      24 .]     201     221 ..     198     221 .. 0.90
   8 !   25.4   0.0   3.5e-09     9e-06       5      23 ..     226     244 ..     223     245 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00021
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                +t+L +++N Ig eGa+ ++
  EFC36370.1 34 ITTLTINYNSIGVEGAMHIS 53
                699**************986 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 3e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ Ld+ +N Ig  Ga+ ++
  EFC36370.1  82 LKCLDIGSNSIGKNGAKYIS 101
                 9***************9875 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 5e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+  N I  eGa++++
  EFC36370.1 106 LTRLDIFNNTICEEGAKSIS 125
                 9****************996 PP

  == domain 4  score: 18.9 bits;  conditional E-value: 4e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L +++NdIg eGa+ ++
  EFC36370.1 130 LTHLKITFNDIGTEGAKYIS 149
                 9***************9885 PP

  == domain 5  score: 19.3 bits;  conditional E-value: 3.1e-07
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                 ++Lt+Ld+s+NdIg +G
  EFC36370.1 152 RKLTHLDISSNDIGAKG 168
                 79*************99 PP

  == domain 6  score: 16.3 bits;  conditional E-value: 2.9e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt L++  NdIg+eG++ ++
  EFC36370.1 177 QLTILNIYNNDIGNEGVKHIS 197
                 69****************986 PP

  == domain 7  score: 17.4 bits;  conditional E-value: 1.2e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt Ld+ +N+I+ eG++ ++
  EFC36370.1 201 QLTRLDIGDNEISAEGVKYIS 221
                 69***************9885 PP

  == domain 8  score: 25.4 bits;  conditional E-value: 3.5e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt Ld+s+N+IgDeGa+ L
  EFC36370.1 226 LTNLDISWNNIGDEGAQFL 244
                 9***************987 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.2      0.01        26      24      55 ..      31      62 ..      20      63 .. 0.83
   2 !   25.7   0.1   2.7e-09     7e-06       2      61 .]      57     116 ..      56     116 .. 0.97
   3 !   20.0   0.1   1.6e-07   0.00042      20      61 .]     123     164 ..     120     164 .. 0.91
   4 !   27.3   0.5   8.6e-10   2.2e-06       2      61 .]     177     236 ..     176     236 .. 0.98

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.01
                -TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8 24 lsnLkvLdLsnNllttlspgafsgLpsLrsLd 55
                +++ ++L +++N++ +  +  +s +++L+ Ld
  EFC36370.1 31 MKGITTLTINYNSIGVEGAMHISKMEQLTNLD 62
                67888999999999998888889999998887 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 2.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+Ld++n+ l + + +  ++l++Lk Ld+++N++    ++ +sg+++L+ Ld+ +N +
  EFC36370.1  57 QLTNLDICNSVLYEEGAKYISQLEQLKCLDIGSNSIGKNGAKYISGMKQLTRLDIFNNTI 116
                 79*******************************************************965 PP

  == domain 3  score: 20.0 bits;  conditional E-value: 1.6e-07
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + + +++L++L+++ N + t  ++ +s+L++L++Ld+s+N++
  EFC36370.1 123 SISEMKQLTHLKITFNDIGTEGAKYISQLRKLTHLDISSNDI 164
                 5677999*********************************97 PP

  == domain 4  score: 27.3 bits;  conditional E-value: 8.6e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++ nN + + + +  + +++L+ Ld+++N+++    + +sg+++L+ Ld+s+N++
  EFC36370.1 177 QLTILNIYNNDIGNEGVKHISEMNQLTRLDIGDNEISAEGVKYISGMKQLTNLDISWNNI 236
                 79********************************************************97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.056   1.4e+02      12      39 ..      19      44 ..       9      48 .. 0.67
   2 !    7.9   0.1    0.0017       4.4       3      33 ..      34      65 ..      32      70 .. 0.83
   3 !   17.8   0.0   1.3e-06    0.0033       2      36 ..      81     116 ..      80     126 .. 0.89
   4 ?    4.9   0.0     0.014        37      17      39 ..     125     140 ..     118     145 .. 0.81
   5 !   15.0   0.1   9.5e-06     0.024       1      39 [.     128     164 ..     128     171 .. 0.88
   6 !   16.1   0.9   4.3e-06     0.011       2      39 ..     153     188 ..     152     195 .. 0.79
   7 !   13.3   0.6   3.5e-05     0.089       2      36 ..     177     212 ..     176     217 .. 0.82
   8 !   15.1   0.1     9e-06     0.023       2      36 ..     201     236 ..     200     240 .. 0.83
   9 !    8.1   0.2    0.0014       3.7       1      28 [.     224     253 ..     224     257 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.056
                ---E-S-.HHH.-TT--EEE-.-S-----G CS
       LRR_4 12 qltdipl.lek.lpnLkeLdLsgNnlitdl 39
                 +  ++  l + ++  ++L+++ N    ++
  EFC36370.1 19 EIGAFDYkLLNlMKGITTLTINYN----SI 44
                566666664455999******888....54 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0017
                --EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  3 LevLdLsnNqltdipl..leklpnLkeLdLsgN 33
                 ++L ++ N +   +   ++k+ +L+ Ld+  N
  EFC36370.1 34 ITTLTINYNSIGVEGAmhISKMEQLTNLDI-CN 65
                6899***9****777798778********9.44 PP

  == domain 3  score: 17.8 bits;  conditional E-value: 1.3e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L+ Ld+++N + + +   ++++++L+ Ld+ +Nn i
  EFC36370.1  81 QLKCLDIGSNSIGKNGAkyISGMKQLTRLDI-FNNTI 116
                 699***********99987668*********.99877 PP

  == domain 4  score: 4.9 bits;  conditional E-value: 0.014
                 S-HHH-TT--EEE-.-S-----G CS
       LRR_4  17 plleklpnLkeLdLsgNnlitdl 39 
                 +    +++L++L +++N    d+
  EFC36370.1 125 SE---MKQLTHLKITFN----DI 140
                 33...9********999....77 PP

  == domain 5  score: 15.0 bits;  conditional E-value: 9.5e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++L +  N + + +   +++l +L++Ld+s+N    d+
  EFC36370.1 128 KQLTHLKITFNDIGTEGAkyISQLRKLTHLDISSN----DI 164
                 589******99***988887668************....87 PP

  == domain 6  score: 16.1 bits;  conditional E-value: 4.3e-06
                 S--EEE--SS---.E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqlt.dipl..leklpnLkeLdLsgNnlitdl 39 
                 +L++Ld+s+N +  +  +  ++ + +L+ L++ +N    d+
  EFC36370.1 153 KLTHLDISSNDIGaKG-SkyISEMNQLTILNIYNN----DI 188
                 8************443.355445*********777....66 PP

  == domain 7  score: 13.3 bits;  conditional E-value: 3.5e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L++ nN +   +   ++ + +L+ Ld+ +N  i
  EFC36370.1 177 QLTILNIYNNDIGNEGVkhISEMNQLTRLDIGDN-EI 212
                 69***********777786445*********556.55 PP

  == domain 8  score: 15.1 bits;  conditional E-value: 9e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-..-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdL.sgNnli 36 
                 +L+ Ld+++N ++  +   ++++++L+ Ld+ ++N  i
  EFC36370.1 201 QLTRLDIGDNEISAEGVkyISGMKQLTNLDIsWNN--I 236
                 69***********777777668*********6555..4 PP

  == domain 9  score: 8.1 bits;  conditional E-value: 0.0014
                 SS--EEE--.SS---E-S-..HHH-TT--EE CS
       LRR_4   1 pnLevLdLs.nNqltdipl..leklpnLkeL 28 
                 ++L++Ld+s n ++ d +   l+++++L +L
  EFC36370.1 224 KQLTNLDISwN-NIGDEGAqfLSQMKQLIYL 253
                 58*******77.****999977789999888 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.35   9.1e+02       4      13 ..      36      52 ..      33      79 .. 0.62
   2 ?    4.8   0.0     0.024        61       1      14 [.      81      94 ..      81     103 .. 0.76
   3 ?    3.0   0.0     0.091   2.3e+02       1      20 [.     105     124 ..     105     127 .. 0.77
   4 ?    2.7   0.0      0.11   2.9e+02       1      20 [.     129     148 ..     129     151 .. 0.78
   5 !    9.7   0.0   0.00058       1.5       1      20 [.     153     172 ..     153     175 .. 0.81
   6 ?    5.3   0.0     0.016        40       1      21 [.     177     197 ..     177     199 .. 0.81
   7 ?    3.9   0.0     0.044   1.1e+02       1      13 [.     201     213 ..     201     223 .. 0.76
   8 !    7.5   0.0    0.0029       7.5       2      19 ..     226     243 ..     225     247 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.35
       LRR_1  4 hLdLsnnpl.......l 13
                +L +++n++       +
  EFC36370.1 36 TLTINYNSIgvegamhI 52
                67777777733333330 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.024
       LRR_1  1 nLrhLdLsnnpllg 14
                +L+ Ld+++n+++ 
  EFC36370.1 81 QLKCLDIGSNSIGK 94
                599*******9854 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.091
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+ nn +   ++ s+
  EFC36370.1 105 QLTRLDIFNNTICEEGAKSI 124
                 599******99866666665 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+hL ++ n ++  ++ ++
  EFC36370.1 129 QLTHLKITFNDIGTEGAKYI 148
                 59********9977666655 PP

  == domain 5  score: 9.7 bits;  conditional E-value: 0.00058
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+hLd+s+n ++ +++ ++
  EFC36370.1 153 KLTHLDISSNDIGAKGSKYI 172
                 7**********977777665 PP

  == domain 6  score: 5.3 bits;  conditional E-value: 0.016
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L+ L++ nn +++ +  +++
  EFC36370.1 177 QLTILNIYNNDIGNEGVKHIS 197
                 599********9887777765 PP

  == domain 7  score: 3.9 bits;  conditional E-value: 0.044
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+++n ++
  EFC36370.1 201 QLTRLDIGDNEIS 213
                 599*******985 PP

  == domain 8  score: 7.5 bits;  conditional E-value: 0.0029
       LRR_1   2 LrhLdLsnnpllglppns 19 
                 L+ Ld+s+n++++ +++ 
  EFC36370.1 226 LTNLDISWNNIGDEGAQF 243
                 899*******97776655 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.034        87      61     126 ..      29      93 ..      17     101 .. 0.77
   2 !   11.7   0.1   5.2e-05      0.13      41     129 ..      79     168 ..      74     186 .. 0.71
   3 !    6.0   0.0     0.003       7.6      41      95 ..     199     252 ..     192     257 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.034
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                  l+k + tl +n n i   +      + +l++l + n+ l e +  + + +l++l++l + +n++ 
  EFC36370.1  29 NLMKGITTLTINYNSIGVEGAMHISKMEQLTNLDICNSVLYEEGA-KYISQLEQLKCLDIGSNSIG 93 
                 578888999999999977777666778888888888888888776.77888888888888777765 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 5.2e-05
       LRR_9  41 ldqfdtidlsdndirkldg..fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                 l+q+  +d+  n i k     +  +k+l  l + nn i+  + +    + +l++l +t n +   +  + + +l+kl+ l + +n + +k 
  EFC36370.1  79 LEQLKCLDIGSNSIGKNGAkyISGMKQLTRLDIFNNTICEEGAKSISEMKQLTHLKITFNDIGTEGA-KYISQLRKLTHLDISSNDIGAKG 168
                 6788888888888877432114557777778888999988888877888888888888888887776.78888888888888888887764 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.003
       LRR_9  41 ldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvl 95 
                 ++q+  +d+ dn+i   +g+ ++  +k l   +    +i+++ +++l ++++l++
  EFC36370.1 199 MNQLTRLDIGDNEIS-AEGVKYISGMKQLTNLDISWNNIGDEGAQFLSQMKQLIY 252
                 5789999*******7.599999999999988888888999***********9996 PP

>> PulA_N1  Pullulanase N1-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.1     0.017        44      26      58 ..      49      81 ..      27      92 .. 0.76
   2 ?   -1.9   0.0       2.3   5.9e+03      29      55 ..     124     150 ..      96     159 .. 0.65
   3 ?    8.4   0.1    0.0014       3.5       4      62 ..     171     229 ..     169     248 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.017
                -EEEEESSEEEEEEEEEEEEESSEEEEEEE-SS CS
     PulA_N1 26 sfllkeedekieLeikekeeleeevkYvcklee 58
                 +++++ ++ ++L+i +++  ee  kY+ +le+
  EFC36370.1 49 AMHISKMEQLTNLDICNSVLYEEGAKYISQLEQ 81
                348889999*******************99875 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 2.3
                 EEESSEEEEEEEEEEEEESSEEEEEEE CS
     PulA_N1  29 lkeedekieLeikekeeleeevkYvck 55 
                 ++e ++ ++L+i      +e  kY+ +
  EFC36370.1 124 ISEMKQLTHLKITFNDIGTEGAKYISQ 150
                 445556666666655555556666655 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0014
                 EEEETTEEEEEEEGGGTTTS-S-EEEEESSEEEEEEEEEEEEESSEEEEEEE-SS---T CS
     PulA_N1   4 YLDelntItillpksyeegesssfllkeedekieLeikekeeleeevkYvckleeelel 62 
                 Y+ e+n++til  ++ + g+    +++e ++ ++L+i + e   e vkY+  +++  +l
  EFC36370.1 171 YISEMNQLTILNIYNNDIGNEGVKHISEMNQLTRLDIGDNEISAEGVKYISGMKQLTNL 229
                 899*******98888888887777999**********************9887766655 PP

>> PapC_C  PapC C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.049   1.3e+02      28      48 ..      91     111 ..      69     114 .. 0.88
   2 ?   -2.9   0.0       2.4   6.2e+03      30      49 ..     141     160 ..     140     163 .. 0.79
   3 ?    6.6   0.0    0.0026       6.7      31      52 ..     214     235 ..     204     249 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.049
                 EB-CCCEEEEECE-SEEEEEE CS
      PapC_C  28 iVgqgGqvylrglpdqgtLtv 48 
                  +g +G  y++g+++  +L++
  EFC36370.1  91 SIGKNGAKYISGMKQLTRLDI 111
                 5899**********9999875 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.4
                 -CCCEEEEECE-SEEEEEEE CS
      PapC_C  30 gqgGqvylrglpdqgtLtvk 49 
                 g +G  y+++l +  +L+++
  EFC36370.1 141 GTEGAKYISQLRKLTHLDIS 160
                 78899999999998888876 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.0026
                 CCCEEEEECE-SEEEEEEES-S CS
      PapC_C  31 qgGqvylrglpdqgtLtvkwge 52 
                  +G  y++g+++  +L+++w++
  EFC36370.1 214 AEGVKYISGMKQLTNLDISWNN 235
                 57889***************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       495  (0.0276089); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1539.55
//
Query:       EFC36371.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.7e-08   34.1   0.0    2.6e-08   33.6   0.0    1.2  1  SBP_bac_3  Bacterial extracellular solute-binding proteins, f


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.6   0.0   1.5e-12   2.6e-08      46     173 ..     145     273 ..     125     291 .. 0.84

  Alignments for each domain:
  == domain 1  score: 33.6 bits;  conditional E-value: 1.5e-12
                 SGGGHHHHHHTTSSSEEESSEB--HHHHTTEEEESESEEEEEEEEEEE.TTSHGTCCHSSCGCG..TTSEEEEETTSHHHHHHHHHHHCTSEEEE.ESS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxx RF
   SBP_bac_3  46 swdelipalksgkvDiaiaaititpeReekvdFsqpyfsagqvllvrk.kdaskissiksladL..kgkkvgvqagstaeellkeelkkgaeive.fdt 140
                  +++l ++++sg +Diaia++ +   R   v F  py +++ ++l  + ++ +    i+s +d+  ++ +v + +gs++++++k ++k +a++++    
  EFC36371.1 145 YFNALKAQVDSGACDIAIASTNFDSIRLPLVHFNCPYGTSSPGFLRSAlDNGT--VIINSESDIdnYNVTVLTYKGSSYDNYVKAKYK-KATLNSiASG 240
                 57788899*************************************99876554..44455566633667999************9887.8899974699 PP

                 HHHHHHHHHTTSSSEEEEEHHHHHHHHHHCCGC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 141 leealqaLkngrvdavvadspvlaylvkknpdk 173
                 ++e ++++ ++++  vvad + la ++k n+d+
  EFC36371.1 241 YTEIFEKILKKEAHIVVADATDLAAFLKSNKDA 273
                 9***************************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       851  (0.047465); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 2018.28
//
Query:       EFC36372.1  [L=278]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (278 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1286  (0.0717274); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 1732.09
//
Query:       EFC36373.1  [L=315]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0011   18.7   9.0     0.0022   17.6   9.0    1.5  1  SR-25           Nuclear RNA-splicing-associated protein
     0.0088   16.3   5.8     0.0088   16.3   5.8    1.9  2  CTNNB1_binding  N-terminal CTNNB1 binding
  ------ inclusion threshold ------
      0.044   14.2   4.8       0.12   12.8   4.8    1.7  1  DUF4685         Domain of unknown function (DUF4685)
       0.07   13.1   0.4       0.15   12.0   0.4    1.5  1  ZIP4_domain     Zinc transporter ZIP4 domain


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   9.0   4.9e-07    0.0022      26     129 ..     127     227 ..     117     243 .. 0.52

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 4.9e-07
       SR-25  26 dssrsssasksqsrkassasekeeerskekkkkkrrrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkakekakaea 124
                  + ++   sk+qs     +++++   s + +k k++  +  s + s+  +ss+ss+ ss s+++k+r   +d +kk +++k  + ++ k++ke++ka+ 
  EFC36373.1 127 ANVNNVKNSKQQSPTVVLVNKSRVPSSGNATKAKPTIVNPNSPTVST--TSSTSSTNSSGSNSEKRRDGLRDVRKKYEEQK-LEEMRIKQMKERNKAHF 222
                 34456666666666666666655566666666666644444444443..33334444444555566666666666666663.33333444444344443 PP

       SR-25 125 aaaea 129
                 a+  +
  EFC36373.1 223 AQEMQ 227
                 33322 PP

>> CTNNB1_binding  N-terminal CTNNB1 binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.2      0.25   1.1e+03     126     141 ..     124     139 ..       8     175 .. 0.59
   2 !   16.3   5.8     2e-06    0.0088      53     172 ..     177     299 ..     167     304 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.25
  CTNNB1_binding 126 pssnkvpvvqpshavh 141
                      ++ +v+ v++s++  
      EFC36373.1 124 QQQANVNNVKNSKQQS 139
                     1233333333333333 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 2e-06
  CTNNB1_binding  53 Essssssseeeaerrrkskkdqesyaekard.sleelrkqqdgglykks...vysgypflmlpdaltspylsngslspssnkvpvvqpshavhpL 143
                      ss++ss++++ +rr   ++ +++y+e++ + +  +++k++++++++++   +   y++l++ ++++    sn+ + +s+n+ p+v+++  v   
      EFC36373.1 177 TSSTNSSGSNSEKRRDGLRDVRKKYEEQKLEeMRIKQMKERNKAHFAQEmqqPCMDYNALVMRENTMYNVPSNQQMGASTNSYPIVNNPNDVISN 271
                     34445555555557777777777887666551444588888888887765557889********9999999********************9999 PP

  CTNNB1_binding 144 tpLitYsnehfspgshpsh.lpadidpktg 172
                        i++   h  p+++ sh +++ i++ tg
      EFC36373.1 272 GTYIPFKASH--PQQSNSHiTSRAISNSTG 299
                     9999988877..444455525566777766 PP

>> DUF4685  Domain of unknown function (DUF4685)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   4.8   2.7e-05      0.12      26     104 ..     124     204 ..     119     227 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.7e-05
     DUF4685  26 RmkartgpLrashdivptvakas..rdgqrsqapkpratlasrdslqsGnlsdssSgesssgqrpkrglspsrVRFeDEsa 104
                  ++a+ +  + s+++ ptv   +  r +++ +a k + t+   +s++   +s +sS +ss ++ +kr+     VR + E  
  EFC36373.1 124 QQQANVNNVKNSKQQSPTVVLVNksRVPSSGNATKAKPTIVNPNSPTVSTTSSTSSTNSSGSNSEKRRDGLRDVRKKYEEQ 204
                 589999************9765533889999999999999999***************99999999999999999655544 PP

>> ZIP4_domain  Zinc transporter ZIP4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.4   3.3e-05      0.15      71     143 ..     178     254 ..     163     263 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3.3e-05
                  TT-HHHHHHHHHH...........HSTTTHHHH.HHHHHHHHHHC---------B-HHHHHHHCSST.....---HHH CS
  ZIP4_domain  71 agswasradlyklylasLlslrqdedsealsenelediLqriqqhyrtsnsqkCvdveslleeaaia.....eesqga 143
                  + +++s ++ +k   + L  +r++ +++ l+e  ++++ +r + h++++ +q C+d + l  + +       +++ ga
   EFC36373.1 178 SSTNSSGSNSEKR-RDGLRDVRKKYEEQKLEEMRIKQMKERNKAHFAQEMQQPCMDYNALVMRENTMynvpsNQQMGA 254
                  2222222223333.688999**************************************98766555445644444455 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1965  (0.109599); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1827.73
//
Query:       EFC36374.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0057   16.1   1.9     0.0065   15.9   1.6    1.3  1  YjcZ           YjcZ-like protein
  ------ inclusion threshold ------
      0.021   15.3   0.7      0.021   15.3   0.7    3.0  3  Baculo_LEF-11  Baculovirus LEF-11 protein
       0.58   10.6   0.1       0.58   10.6   0.1    2.8  2  Goodbye        fungal STAND N-terminal Goodbye domain
        1.3    9.2  11.0        1.5    8.9   5.9    2.6  3  Herpes_BLRF2   Herpesvirus BLRF2 protein


Domain annotation for each model (and alignments):
>> YjcZ  YjcZ-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   1.6   1.5e-06    0.0065      42     160 ..     116     232 ..      73     234 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.5e-06
        YjcZ  42 seinaevnaalelrLkllekLsreldpghLALttiaqrlallsqtlaekasaapklaqalaalaeefaarverkekaltqrellvqarrhseqifarWr 140
                  + ++ ++++l+l+ +l e++ +el++ + AL + +++  l +  +++ ++a++kl+++++   e+f++ + ++e+ l ++e    a++++e++f + +
  EFC36374.1 116 RQKEPIMTHNLHLKRQLKENVDNELEQLKQALEEKQDQEFLDKYLDKRSKKAVNKLRKKMEREGEDFKKNIVEREEYLFRKENYITAEKRIEDTFNKLK 214
                 4567889999************************99998888888888899**********************************************99 PP

        YjcZ 141 aGafdgwslsGRCfvaLeeL 160
                     +++       vaL+eL
  EFC36374.1 215 VSYINSLTTEE--KVALKEL 232
                 88877655443..4666665 PP

>> Baculo_LEF-11  Baculovirus LEF-11 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.3   0.7   4.6e-06     0.021      15      77 ..      46     106 ..      42     119 .. 0.83
   2 ?    1.0   1.3      0.13     6e+02      41      91 ..     118     173 ..     100     175 .. 0.62
   3 ?    0.2   0.5      0.24   1.1e+03      35      71 ..     190     221 ..     165     249 .. 0.52

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 4.6e-06
  Baculo_LEF-11  15 intlkstndtedvtahhldtdsFetirefirehadvivrknskrkavadHlkRlarLlsldkv 77 
                    +n +k++n   + + +   ++sFe+i e + +  d+ + k+   k  a+H++R a   +l ++
     EFC36374.1  46 VNRKKEQNSYRNSMKN--TMQSFERIEEIVAQGVDQCMSKKKSSKGLAPHHHRKAVDDDLGNM 106
                    899*********9999..6678******************************97655555555 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.13
  Baculo_LEF-11  41 refirehadvivrknskrk...avadHlkRlarLl.......sldkvirdeYkrvvnkvyk 91 
                    +e i +h+        kr+    v + l+ l++ l        ldk + +  k++vnk  k
     EFC36374.1 118 KEPIMTHNLH-----LKRQlkeNVDNELEQLKQALeekqdqeFLDKYLDKRSKKAVNKLRK 173
                    3334444433.....3333333588888888888888888777888888888888888655 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.24
  Baculo_LEF-11  35 dsFetirefirehadvivr.knskrkavadHlkRlarL 71 
                    ++      ++  ++++i+  k  +  + ++  + ++ L
     EFC36374.1 190 EE------YLFRKENYITAeKRIEDTFNKLKVSYINSL 221
                    33......333444444321233333444444444444 PP

>> Goodbye  fungal STAND N-terminal Goodbye domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   0.00013      0.58      35      74 ..      41      78 ..      15      82 .. 0.80
   2 ?   -1.0   4.0      0.51   2.3e+03      26      55 ..     139     171 ..     122     215 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00013
     Goodbye 35 eaekdkfeefrekkeklkealkkilspiqllggiaaqgas 74
                +++k+   + ++++++ ++++k++++ ++ + +i+aqg+ 
  EFC36374.1 41 DDKKK--VNRKKEQNSYRNSMKNTMQSFERIEEIVAQGVD 78
                33333..4445888999********************986 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.51
     Goodbye  26 svedllkqieaekdkfeefr...ekkeklkeal 55 
                 ++e+l + +e+++d+   ++   ++++k+ + l
  EFC36374.1 139 ELEQLKQALEEKQDQEFLDKyldKRSKKAVNKL 171
                 556666666666553222222323333333333 PP

>> Herpes_BLRF2  Herpesvirus BLRF2 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1     0.037   1.7e+02      39      79 ..      48      88 ..      27     103 .. 0.74
   2 ?    8.9   5.9   0.00034       1.5      17      67 ..     124     178 ..     118     215 .. 0.84
   3 ?   -1.7   0.0       0.7   3.1e+03      56      68 ..     202     214 ..     187     233 .. 0.60

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.037
  Herpes_BLRF2 39 aekeavltstvgrlsskaakkieervrkevlkvvtknevee 79
                  ++ke    +   + + ++ ++iee v + v++ ++k++   
    EFC36374.1 48 RKKEQNSYRNSMKNTMQSFERIEEIVAQGVDQCMSKKKSSK 88
                  44554444555566889999*******99999999987665 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00034
  Herpes_BLRF2  17 ENkaLkkklkssvs....pkdeeLTaaekeavltstvgrlsskaakkieervrke 67 
                    N +Lk++lk++v+       + L +++ +  l +  ++ s+ka +k+++++++e
    EFC36374.1 124 HNLHLKRQLKENVDneleQLKQALEEKQDQEFLDKYLDKRSKKAVNKLRKKMERE 178
                   699***********44444455566677788899999999999999999999876 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.7
  Herpes_BLRF2  56 aakkieervrkev 68 
                   a+k+ie+  +k  
    EFC36374.1 202 AEKRIEDTFNKLK 214
                   6677776666542 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3382  (0.188633); expected 358.6 (0.02)
Passed bias filter:                      539  (0.030063); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 1541.83
//
Query:       EFC36375.1  [L=650]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00065   19.4   3.6    0.00065   19.4   3.6    3.2  3  LRR_8           Leucine rich repeat
  ------ inclusion threshold ------
       0.32   11.0   2.4          4    7.5   1.9    3.2  2  Staphostatin_B  Staphostatin B


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       0.6   5.4e+03      11      25 ..     294     308 ..     290     309 .. 0.75
   2 ?   -2.1   1.4      0.37   3.3e+03      45      57 ..     358     370 ..     328     374 .. 0.59
   3 !   19.4   3.6   7.3e-08   0.00065       2      39 ..     414     451 ..     413     471 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.6
                 S--SEE-TTSSTT-T CS
       LRR_8  11 NrltslddeaFkgls 25 
                  +lt+++d aF ++s
  EFC36375.1 294 KSLTNIEDVAFPKFS 308
                 579999999997766 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.37
                 GTT--S-.EEE-- CS
       LRR_8  45 fsgLpsLrsLdLs 57 
                    L+ L+sL L+
  EFC36375.1 358 KLELNLLQSLKLN 370
                 3345566666665 PP

  == domain 3  score: 19.4 bits;  conditional E-value: 7.3e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt 39 
                  L++L +snN ++ +d e+ ++ + L +LdL++N+l+ 
  EFC36375.1 414 ALHNLKISNNEIETIDLETLNSHKYLAYLDLRHNKLSD 451
                 599999****************************9986 PP

>> Staphostatin_B  Staphostatin B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.21   1.9e+03      19      34 ..     452     467 ..     438     473 .. 0.78
   2 ?    7.5   1.9   0.00044         4       4      37 ..     536     569 ..     533     637 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.21
                     HHHHHTT-EEEEETTT CS
  Staphostatin_B  19 qtninlfignwsnhql 34 
                       nin+++g++s+ +l
      EFC36375.1 452 PDNINMIVGKYSQLDL 467
                     469********98776 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.00044
                     EEEEE--GGGS-HHHHHHHHTT-EEEEETTTTEE CS
  Staphostatin_B   4 finlvydttklthleqtninlfignwsnhqlqks 37 
                     +i+++ +  klt +e+tn+ ++  n+sn q   s
      EFC36375.1 536 LIQVIENPKKLTSIENTNVIFWNNNYSNNQKSFS 569
                     678888999*******************986655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (650 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 3611.31
//
Query:       EFC36376.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-48  162.5  13.8    6.6e-06   26.6   0.0    8.1  8  Sel1      Sel1 repeat
  ------ inclusion threshold ------
      0.071   13.2   0.0       0.41   10.7   0.0    2.1  2  HTH_16    Helix-turn-helix domain


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.032   2.9e+02      12      32 ..      44      65 ..      42      70 .. 0.70
   2 !   19.6   0.0   1.2e-07    0.0011       6      38 .]      76     107 ..      74     107 .. 0.87
   3 !   26.6   0.0   7.3e-10   6.6e-06       2      37 ..     109     142 ..     108     143 .. 0.90
   4 !   23.1   0.0   9.3e-09   8.3e-05       3      32 ..     146     173 ..     144     174 .. 0.89
   5 !   21.6   0.0   2.9e-08   0.00026       4      38 .]     183     215 ..     180     215 .. 0.90
   6 !   25.3   0.0   1.9e-09   1.7e-05       2      38 .]     217     251 ..     216     251 .. 0.91
   7 !   20.2   0.4   7.7e-08   0.00069       1      38 []     252     287 ..     252     287 .. 0.94
   8 !   25.9   0.0   1.3e-09   1.1e-05       3      37 ..     290     322 ..     288     323 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.032
        Sel1 12 lylnGlgvpk.DpekAiewyek 32
                + + G    + D+ekA+e++ k
  EFC36376.1 44 YQFGGNNKSPiDEEKALELMIK 65
                33444454556*******9866 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 1.2e-07
        Sel1   6 rLGmfylylnGl.gvpkDpekAiewyekAAeqGd 38 
                 + G   ++++G+  +p D ekA+ wy+k+A++G+
  EFC36376.1  76 QIG--SFHYFGKaNLPIDFEKALFWYRKSANNGN 107
                 678..777****55999***************97 PP

  == domain 3  score: 26.6 bits;  conditional E-value: 7.3e-10
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                  Am+++G  +ly+ G+g  k++++A+ w+ +AA +G
  EFC36376.1 109 IAMFNVG--LLYDRGQGCNKNVKEAFNWFFRAAVAG 142
                 6******..777********************9655 PP

  == domain 4  score: 23.1 bits;  conditional E-value: 9.3e-09
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyek 32 
                 +++ +Gm+   + G g++kD+++Ai+w+ +
  EFC36376.1 146 SQFYVGMMF--DRGEGTEKDIQQAIYWLNQ 173
                 89****666..****************976 PP

  == domain 5  score: 21.6 bits;  conditional E-value: 2.9e-08
        Sel1   4 myrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +  L+   +y++G  +++D++kA+ ++ + A++G+
  EFC36376.1 183 LTYLA--SMYEKGENIEQDYSKAFPLFLQGANMGH 215
                 56799..777************************9 PP

  == domain 6  score: 25.3 bits;  conditional E-value: 1.9e-09
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 e+ y +G   +yl G+gv+ ++ +A++++ +AA +++
  EFC36376.1 217 ECIYHVG--VMYLSGRGVEVNYPLALKYFLMAATRNH 251
                 67799**..777*********************9987 PP

  == domain 7  score: 20.2 bits;  conditional E-value: 7.7e-08
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 aeA+y+ G++y  + G g  +D+ + ++++   A++G+
  EFC36376.1 252 AEAQYNAGTMY--DRGMGCLQDYTESFKLFMSGAMNGH 287
                 79******999..*****************99999998 PP

  == domain 8  score: 25.9 bits;  conditional E-value: 1.3e-09
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 ++y +G   ++l+G g+  D++ Ai w++kAA qG
  EFC36376.1 290 CQYYVG--NMLLKGEGTLVDVKHAIFWMKKAALQG 322
                 79****..666*********************998 PP

>> HTH_16  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   4.6e-05      0.41       6      23 ..      28      45 ..      27      46 .. 0.95
   2 ?   -1.6   0.0      0.32   2.9e+03       6      16 ..     102     112 ..     101     119 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 4.6e-05
      HTH_16  6 aAvnGDeeAieeiLkhYe 23
                +A +GD++A++e+L++Y+
  EFC36376.1 28 RANEGDQQALDELLNYYQ 45
                79***************7 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.32
      HTH_16   6 aAvnGDeeAie 16 
                 +A nG+  A+ 
  EFC36376.1 102 SANNGNSIAMF 112
                 799******95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       531  (0.0296168); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 2157.85
//
Query:       EFC36377.1  [L=675]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.6e-08   33.2   0.0    1.1e-07   31.6   0.0    1.8  1  Peptidase_S41    Peptidase family S41


Domain annotation for each model (and alignments):
>> Peptidase_S41  Peptidase family S41
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.6   0.0     6e-12   1.1e-07       2     118 ..     227     418 ..     226     440 .. 0.78

  Alignments for each domain:
  == domain 1  score: 31.6 bits;  conditional E-value: 6e-12
                    EEEEEES-BCCTHHHHHHHHHHHHHH.......TTSSEEEEE-TTB-EBEHHHHHHHHHCCSSSSEEEEEECTTSEEE.................. CS
  Peptidase_S41   2 iGyiripsfsektkeelakalkelkk.......knvkglilDlRnNgGGlldeavelaslflddglivstrgrdgkkk.................. 72 
                    iG+i i+ f   + ++++++ +++++        ++k++ilD++nNgGG++   ++ +++f++++   ++++   +++                  
     EFC36377.1 227 IGVIVIEIF---SPKSIQQFSRDFQTslylaklHKAKKIILDVTNNGGGYICLGYAFSRYFFPKQFSNQYESLFARTDmiaselgkelaqkgsesp 319
                    788899999...4555555555555555555568**********************************9999999999999999999999999999 PP

                    .............................................EEEHTCSS-S................TT-BSSEEEEEE-TTBBTHHHHHHH CS
  Peptidase_S41  73 .............................................kksktekase................evqykgplvvLvnegsaSaseifag 107
                                                                          +                    +  l++L n+++aS   +f+ 
     EFC36377.1 320 qldtiwmphfwrddsgkvynddswftnqhtfsrggvdhaytsiikD--------NgcsemfddfiftgddlLDYSSDDLIILSNGRCASTCAMFTF 407
                    9999999999998888888887777776666666666555544440........055555666666666663347899****************** PP

                    HHHHTTSEEEE CS
  Peptidase_S41 108 alkdngratlv 118
                     l++ + a+ v
     EFC36377.1 408 QLQQFKKAKTV 418
                    ***99998533 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (675 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       972  (0.0542138); expected 358.6 (0.02)
Passed bias filter:                      657  (0.0366445); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.28s 00:00:00.96 Elapsed: 00:00:00.45
# Mc/sec: 4462.01
//
Query:       EFC36378.1  [L=320]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-07   29.6   0.0    8.2e-07   28.8   0.0    1.5  1  Ras       Ras family
  ------ inclusion threshold ------
       0.14   12.1   1.6       0.66    9.9   0.2    2.7  4  Sec20     Sec20


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0   9.2e-11   8.2e-07      63     141 ..     198     293 ..     158     309 .. 0.82

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 9.2e-11
                 HHHHHHHTT..ESEEEEEE...ETTBHHHHHTHHHHHHHHHHHSTTTSEEEEEEETTTGGG...........G-SS-HHHHHHHHHHHT.SEEEEE CS
         Ras  63 slrelyyrd..aegillvy...ditsresfenvkkwveeikrvaeenvpivLvGnKvDlee...........kravsteegeelakelg.lkflet 141
                 +l + +y++   +g+llv    d++++  ++++  wv+++++v +++vpivL+Gn +D ++           +  +ste+ge+la++lg ++++e+
  EFC36378.1 198 NLLHICYKShvHHGFLLVIdtvDVSENYLLNELPLWVKDLRSVISDSVPIVLIGNNADKRDallstqhkledRLPLSTEQGEKLAEKLGcFTYIEM 293
                 55555555422468888762225778888999**************************************97778**************999*997 PP

>> Sec20  Sec20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.2   7.4e-05      0.66      40      76 ..      42      77 ..       8      79 .. 0.76
   2 ?   -1.2   0.0      0.23     2e+03      41      61 ..     161     181 ..     151     203 .. 0.69
   3 ?   -1.8   0.0      0.33     3e+03      49      68 ..     190     209 ..     170     217 .. 0.62
   4 ?   -3.3   0.0      0.99   8.8e+03      47      70 ..     236     259 ..     233     261 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 7.4e-05
       Sec20 40 kleeeykqvedvlsrskklvkklerrdktdkllvfla 76
                + e++  q++++ls  +  +k++er++++d ++++++
  EFC36378.1 42 S-EQGKLQFNSLLSEKNLYLKFMERSERIDEIKIIIG 77
                3.3444699*************************998 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.23
       Sec20  41 leeeykqvedvlsrskklvkk 61 
                 le+e+++ +  l++ +kl++ 
  EFC36378.1 161 LEQEFMGENVYLRKLRKLIEN 181
                 667777777777777777764 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.33
       Sec20  49 edvlsrskklvkklerrdkt 68 
                 ++ l++sk+l+    ++ + 
  EFC36378.1 190 SQELEQSKNLLHICYKSHVH 209
                 44566777777666665555 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 0.99
       Sec20  47 qvedvlsrskklvkklerrdktdk 70 
                 ++++v+s s  +v   +++dk d 
  EFC36378.1 236 DLRSVISDSVPIVLIGNNADKRDA 259
                 567899999999999999998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       972  (0.0542138); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 2007.08
//
Query:       EFC36379.1  [L=343]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.5e-26   91.4   0.2    6.8e-26   90.8   0.2    1.2  1  Ras          Ras family
    9.4e-09   35.5   0.0    1.9e-08   34.5   0.0    1.5  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    1.5e-05   24.9   0.2      0.042   13.8   0.1    2.2  2  RsgA_GTPase  RsgA GTPase
    0.00065   19.3   0.1     0.0011   18.6   0.1    1.3  1  GTP_EFTU     Elongation factor Tu GTP binding domain
     0.0027   17.7   0.1        1.6    8.8   0.0    2.3  2  CbiA         CobQ/CobB/MinD/ParA nucleotide binding domain
     0.0035   17.2   0.4      0.012   15.5   0.1    1.9  2  ATP_bind_1   Conserved hypothetical ATP binding protein
     0.0049   16.3   2.0      0.045   13.1   0.4    2.2  2  Gtr1_RagA    Gtr1/RagA G protein conserved region
  ------ inclusion threshold ------
       0.02   14.4   0.1      0.036   13.5   0.1    1.4  1  ParA         NUBPL iron-transfer P-loop NTPase
      0.043   13.7   0.0      0.099   12.5   0.0    1.8  1  NTPase_1     NTPase
       0.18   11.4   1.9       0.33   10.4   0.2    2.1  2  FeoB_N       Ferrous iron transport protein B


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.8   0.2   3.8e-29   6.8e-26       1     158 [.     133     300 ..     133     303 .. 0.88

  Alignments for each domain:
  == domain 1  score: 90.8 bits;  conditional E-value: 3.8e-29
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K+v++G+++vGK+++++++++d F e+y++Ti +  y+k++ vdg    +e++D A   e++s r+  +r +e+++lv d+ + +s e+++ +ve++ r
  EFC36379.1 133 KVVMIGKGGVGKSAMTVKYIQDFFIEQYDPTI-EGVYRKQLLVDGFPTLFEVLDSAE-HEYSSARDHHMRYGECFVLVCDLADINSVEEAEPLVEQLVR 229
                 9*******************************.***********************5.67*************************************** PP

                 HST...TTSEEEEEEETTTGGG..G-SS-HHH.HHHHH......HHHTSEEEEEBTTTTCTHHHHHHHHHH CS
         Ras 100 vae...envpivLvGnKvDlee..kravstee.geela......kelglkfletSAktnenveeafeellr 158
                 v++   +++p+v   nKvDl +  +r ++ e+  +++a      + +++  +etSAkt en++ ++ee++r
  EFC36379.1 230 VKDfeeNSFPVVFALNKVDLLNetDRPITIEKfTNQIAtlikqtQLTNTFIIETSAKTGENITRVYEECAR 300
                 *9999889************88777777776623344455533223335568***************9987 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   0.0   1.1e-11   1.9e-08       1     119 [.     133     248 ..     133     249 .. 0.78

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 1.1e-11
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 Kvv++G++gvGK+ +  ++++d f e++++ti   +  k++  ++g+          +++ D a + +++s +++++r  ++++lv+d    +s e+++
  EFC36379.1 133 KVVMIGKGGVGKSAMTVKYIQDFFIEQYDPTIEGVYR-KQL-LVDGF-------PTLFEVLDSAEH-EYSSARDHHMRYGECFVLVCDladINSVEEAE 221
                 9*******************************97665.555.35664.......3579****9965.589999*************9976544556666 PP

                 HHHHHH...HHHCSSS.-EEEEEE-TT CS
         Roc  97 eWlkel...kkvagks.pvilvgnkiD 119
                 + +++l   k+  ++s pv++  nk+D
  EFC36379.1 222 PLVEQLvrvKDFEENSfPVVFALNKVD 248
                 5555541116666676799999****9 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0   0.00064       1.1      97     117 ..     129     149 ..      92     160 .. 0.80
   2 !   13.8   0.1   2.3e-05     0.042      41      98 ..     232     299 ..     208     304 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00064
                  CTTSEEEEECSTTSSHHHHHH CS
  RsgA_GTPase  97 lkdktsvlvGqSGvGKStLin 117
                  +++  +v++G+ GvGKS++  
   EFC36379.1 129 IDETKVVMIGKGGVGKSAMTV 149
                  5667899**********9865 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 2.3e-05
                  HHHHTT-EEEEEEE-GGG--HHH..........HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCT CS
  RsgA_GTPase  41 laeekgiepvivlnKiDlleeee..........eleelkeelealgyevllvsaktkegleelkellk 98 
                   +ee+  ++v +lnK+Dll+e++          ++ +l ++++ +++ ++ +sakt+e+++++ e+++
   EFC36379.1 232 DFEENSFPVVFALNKVDLLNETDrpitiekftnQIATLIKQTQLTNTFIIETSAKTGENITRVYEECA 299
                  5789999****************9**9999998899999999999999999*******9999988765 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.1     6e-07    0.0011      73     183 ..     182     311 ..     167     321 .. 0.69

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 6e-07
                 EEEEESSSGGGHHHHHHHHHT-SEEEEEEETT.....TBSTHHHHHHHHH..HHHTTTEEEEEEESCGST.HHHHHHHHHHHHHHHHHHHHHHHHHHHT CS
    GTP_EFTU  73 nliDtPGHvdFskevirglrvlDgavlvvdav.....eGvepqteevlrl..alkegvpiivfiNKmDrl.kaelkeiveevkqklsrkeeklekygek 163
                  ++D+  H ++s+   + +r  ++ vlv+d +     e  ep  e+++r+    ++  p+++++NK+D l +++   ++e+  +++    + +++ +  
  EFC36379.1 182 EVLDSAEH-EYSSARDHHMRYGECFVLVCDLAdinsvEEAEPLVEQLVRVkdFEENSFPVVFALNKVDLLnETDRPITIEKFTNQI---ATLIKQTQLT 276
                 56666655.588888899999999999999875555577999999998872245666779**********7555555556666666...3334444333 PP

                 TTTTEEEEEEBTTTTBTHH..................H CS
    GTP_EFTU 164 gekevpvvfgSalkgegvk..................t 183
                    ++ ++ +Sa++ge+++                  t
  EFC36379.1 277 ---NTFIIETSAKTGENITrvyeecarlkrygsvdnlT 311
                 ...578*************5555555555555555555 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0    0.0009       1.6       2      21 ..     134     153 ..     133     161 .. 0.83
   2 !    6.9   0.0    0.0035       6.2      54     125 ..     236     330 ..     179     333 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0009
                 EEEESSTTSSHHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxx RF
        CbiA   2 aiastkGGvGKTtlaanLar 21 
                 +++ +kGGvGK+ ++++ ++
  EFC36379.1 134 VVMIGKGGVGKSAMTVKYIQ 153
                 57789**********98766 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0035
                 H.....................CCHCCCHHHHHHCHCHHHH..EEEEEEEEESS...-TTCHHHHHHHHHHC....TS-EEE.EEE--CCHCCCCHHT CS
                 x.....................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxx.xxxxxxxxxxxxxxx RF
        CbiA  54 p.....................dlkrllellealgkkkalllkiagvvlnrvdgeneetllkealeelkqry....gvpvlg.viprdeavaeaparg 125
                 +                     +++++ + +++l k+++  l+  +++ +  +  +++t+ +e +++lk ry    ++ +l+ vi  d+a++e  +++
  EFC36379.1 236 NsfpvvfalnkvdllnetdrpiTIEKFTNQIATLIKQTQ--LTNTFIIETSAKTGENITRVYEECARLK-RYgsvdNLTLLKeVIQHDSAFIETCKKQ 330
                 055555555555555566666678888888888887755..99************************98.67799999999999**999999987765 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.54   9.6e+02       2      17 ..     137     152 ..     136     167 .. 0.79
   2 !   15.5   0.1   6.5e-06     0.012     119     212 ..     200     299 ..     176     318 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.54
  ATP_bind_1   2 vGpaGsGKttfvgals 17 
                 +G  G+GK+ ++ + +
  EFC36379.1 137 IGKGGVGKSAMTVKYI 152
                 8999*****9976654 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 6.5e-06
  ATP_bind_1 119 es.efalvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek.lekeleffedvealslllekee.......ekykklaeaiaell 208
                    e  + v  L+D + ++++  ++++ l+ ++   + + P v +lnk+Dll+e  +   +e f++   + +l+++++       e  +k  e+i ++ 
  EFC36379.1 200 RYgECFVLVCDLADINSVEEAEPLVEQ-LVRVKDFEENSFPVVFALNKVDLLNETdRPITIEKFTNQ--IATLIKQTQltntfiiETSAKTGENITRVY 295
                 44556677777899999999999**99.999**********************88888899999854..444444433345677766667777776666 PP

  ATP_bind_1 209 eefa 212
                 ee a
  EFC36379.1 296 EECA 299
                 6655 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.1      0.05        89       1      16 [.     133     148 ..     133     159 .. 0.91
   2 !   13.1   0.4   2.5e-05     0.045      63     158 ..     188     284 ..     181     292 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.05
   Gtr1_RagA   1 kvLLmGksgsGKtsmr 16 
                 kv+++Gk+g GK++m 
  EFC36379.1 133 KVVMIGKGGVGKSAMT 148
                 899***********96 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 2.5e-05
   Gtr1_RagA  63 eeylssqkeeifrnvgvliyVfDvesreleedletlkeilealrqyspeakvfvl.ihKmDliqedereeifeerkeeireeieklekeeiqffaTS 158
                 e+ +ss +++ +r  +  + V D  + +  e+ e l+e l ++++++++    v+ ++K+Dl++e  r  ++e+ +++i   i++++ +++ +  TS
  EFC36379.1 188 EHEYSSARDHHMRYGECFVLVCDLADINSVEEAEPLVEQLVRVKDFEENSFPVVFaLNKVDLLNETDRPITIEKFTNQIATLIKQTQLTNTFIIETS 284
                 5667889999999999*********99989999999999999999998876555449***************************9998888888887 PP

>> ParA  NUBPL iron-transfer P-loop NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1     2e-05     0.036       4      23 ..     131     150 ..     128     159 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2e-05
        ParA   4 kviavlSgKGGVGKStvavn 23 
                 ++ +v+ gKGGVGKS ++v+
  EFC36379.1 131 ETKVVMIGKGGVGKSAMTVK 150
                 666899***********986 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   5.5e-05     0.099       2      82 ..     134     212 ..     133     283 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.5e-05
                 EEEE--TTSSHHHHHHHHHHH..H...GGGEEEEEEEEE-------EEEEEET.T--EEEEEETT---SSEETTEEE-HHHHH CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlel..lkssgvkvgGfyteevreggrrigFkivdlasgeegiLarveakreprvgkyvvdvesfe 82 
                 v++ G+ GvGK+ +  k ++   +++ + +++G+y ++   +g  + F++ d    e+++ + +   +++r g+  v v ++ 
  EFC36379.1 134 VVMIGKGGVGKSAMTVKYIQDffIEQYDPTIEGVYRKQLLVDGFPTLFEVLDS--AEHEYSSAR--DHHMRYGECFVLVCDLA 212
                 77889*********9999996336777889********************998..333333333..36777787777766555 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1      0.74   1.3e+03       2      16 ..     133     147 ..     132     152 .. 0.87
   2 ?   10.4   0.2   0.00019      0.33      85     139 ..     217     271 ..     205     298 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.74
                 EEEEEESTTSSHHHH CS
      FeoB_N   2 tvalvGnpnvGkttl 16 
                 +v+++G+  vGk+++
  EFC36379.1 133 KVVMIGKGGVGKSAM 147
                 799*********987 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00019
                 EEEGGGHHHHHHHHHHHHHTTSSEEEEEETHHHHHHTTEEE-HHHHHHHHTS-EE CS
      FeoB_N  85 vvdatnlernLyLtlqllelgvpvvlalnmideaekkgieidlkkLsekLgvpvv 139
                 v +a+ l  +L+ + +  e + pvv aln++d ++++   i ++k+++++ + + 
  EFC36379.1 217 VEEAEPLVEQLVRVKDFEENSFPVVFALNKVDLLNETDRPITIEKFTNQIATLIK 271
                 667788888888888999999****************999999998877654332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.59u 0.25s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2197.96
//
Query:       EFC36380.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.1e-05   22.1   5.7    0.00013   21.6   5.7    1.2  1  UCH       Ubiquitin carboxyl-terminal hydrolase


Domain annotation for each model (and alignments):
>> UCH  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   5.7   7.3e-09   0.00013      27     256 ..      24     288 ..      15     289 .. 0.69

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 7.3e-09
                 HHHHTCHHCCSSTCCCCC-.TT.TTS.TTHHHHHHHHHHHHHHSH-CCEE--HHHHHHHHHHSGGGTSSSTCEHHHHHHHHHHHHHHHHCCHCCCHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH  27 dyllsleevkkesrnkkelnesnplgkkgelakalkdlfkellkskskavsPkklkktlsklaksfsgykqqDaqEflaflLdqlhedlnrevaeekwk 125
                 ++ll+l + +  +r+++ + +s++++ + e+++a+ ++ ++++++++ ++  +++++++s +     + k  D +E+++f + +++   +    +++ k
  EFC36380.1  24 QVLLHLDPIM--NRYNNYNINSHSSKIESEMLQAFDSIGRKVWNNQELEIDISEFYSFFSLET----WDKFIDLEEMFQFTITNCKLLNQY--FNTTEK 114
                 4444433332..333333333566677778*************87677777777777666554....457789999999999886543333..233446 PP

                 HHCCCTTSHHHHHH-EEEEE...............................................EEEEEEB-SEEEEEEESEEETEEEEE--SEEB CS
                 xxxxxxxxxxxxxxxxxxxx...............................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH 126 khlkrndslitdlfegqlks...............................................klklkrlPeiLiihlkRfsynssksKlntkve 177
                 ++++ + ++  ++ +g+ ++                                               k ++ ++PeiL+++l   s++++   ++ +v 
  EFC36380.1 115 RTTTFEICPTCQIDYGKKENisnyctfiyskdkwkqfretneiyqdpipfikgyhctscysfleimlKSTIIEAPEILLLKLH-SSIENNYFLYEFNVH 212
                 6666666666666666666677777777777999999999999999999999999999************************9.444444233333333 PP

                 --SEEE-GGGBSS-BTTS-TCS-BEEEEEEEEEESCTTSEEEEEEEECTTTTEEEEEETTEEEEE-HHCCCTT.......CEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......xxxxxx RF
         UCH 178 fpeeldlssylaeekkkkteekkkYeLiavvvHsGslssGHYvayiknekngkWykydDetvkevkeeeevls.......sayiLf 256
                    +l +++ ++      ++++++YeL+avv ++   ++G Y  + kn+ n +Wy+++ ++++   +   v+        s +iLf
  EFC36380.1 213 EHVKLLVDESID------NSHHQEYELVAVVDYYR--ERGIYGGFFKNPMNRRWYQMNAHSIDDFPKL--VEDlscinstSNFILF 288
                 333444444443......234556*********97..999********************99988733..2223344445666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       899  (0.0501422); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 2057.06
//
Query:       EFC36381.1  [L=110]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.055   12.3   0.6      0.058   12.3   0.6    1.1  1  tRNA-synt_1c  tRNA synthetases class I (E and Q), catalytic d


Domain annotation for each model (and alignments):
>> tRNA-synt_1c  tRNA synthetases class I (E and Q), catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.6   3.2e-06     0.058      93     184 ..      24     110 .]       3     110 .] 0.88

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.2e-06
                   SEEEE-STHHHHHHHHCCSSHSS-TTTTS-HHHHHHHHHHHHHTTHSTTTS-EEEESSBTTSS.GGGSSTEEEEEEESGGGSBTTTBTSTSEE CS
  tRNA-synt_1c  93 kAYvcectkeeleeereeqeklgskerdrydeenlklfeeemkkgkaegekavvRlkideess.vefrDlvrgriklepqeihdlvivksdiy 184
                   ++Yv+ +++e l   re+    g   r++  e +++   e  k++++  + ++v +k    ++  +f +  r ri++ p+ ++d++++k+ iy
    EFC36381.1  24 HGYVAGDSSETLPGGREK----G--PREHFEEICRDENYEIEKHHTNVRGDYTVVFKHKYGGKdQTFPNISRERIENMPSRVKDVILKKKSIY 110
                   78999999****999988....4..3677888888888776677788899***********999*************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (110 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       412  (0.0229795); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.32s 00:00:00.72 Elapsed: 00:00:00.48
# Mc/sec: 691.13
//
Query:       EFC36382.1  [L=467]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-20   71.1  42.6     0.0015   18.4   0.1   13.0 14  LRR_6     Leucine Rich repeat
    2.5e-15   56.3  54.3     0.0014   19.0   4.2   10.0 11  LRR_4     Leucine Rich repeats (2 copies)
    5.2e-15   55.0  42.4    2.3e-05   24.0   8.3    6.9  7  LRR_8     Leucine rich repeat
    5.5e-05   23.2  30.4        2.8    8.8   0.2   10.5 11  LRR_1     Leucine Rich Repeat
    0.00025   20.6  24.4      0.062   12.8   2.2    5.0  5  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
      0.039   14.4   0.1       0.29   11.6   0.0    2.6  2  HTH_26    Cro/C1-type HTH DNA-binding domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.3      0.17   5.1e+02       3      15 ..      64      76 ..      62      77 .. 0.87
   2 ?   -3.4   0.0       5.2   1.5e+04       4      12 ..      89      97 ..      87      97 .. 0.76
   3 !    6.2   0.1    0.0043        13       3      16 ..     137     150 ..     135     151 .. 0.87
   4 ?   -2.6   0.1       2.7   8.1e+03       3      10 ..     169     176 ..     165     177 .. 0.71
   5 ?    1.9   0.1     0.097   2.9e+02       4      21 ..     189     206 ..     186     209 .. 0.87
   6 !   14.0   0.0   1.3e-05     0.038       5      24 .]     214     233 ..     210     233 .. 0.92
   7 !   18.4   0.1   5.1e-07    0.0015       5      24 .]     239     258 ..     235     258 .. 0.91
   8 !   11.8   0.0   6.6e-05       0.2       3      24 .]     261     282 ..     259     282 .. 0.93
   9 ?    2.3   0.0     0.076   2.3e+02       5      17 ..     287     299 ..     286     300 .. 0.91
  10 ?    2.3   0.1     0.075   2.3e+02       3      24 .]     308     329 ..     306     329 .. 0.89
  11 !    9.5   0.2   0.00035       1.1       3      18 ..     332     347 ..     331     350 .. 0.93
  12 !    8.8   0.1   0.00061       1.8       4      19 ..     358     373 ..     355     378 .. 0.83
  13 !    5.2   0.4     0.009        27       3      24 .]     381     402 ..     379     402 .. 0.92
  14 !   11.4   0.0     9e-05      0.27       3      19 ..     405     421 ..     403     426 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.17
       LRR_6  3 thLteLdLsgNdI 15
                t L++  L++N+I
  EFC36382.1 64 TQLKSIVLKFNNI 76
                679*********9 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 5.2
       LRR_6  4 hLteLdLsg 12
                +L +Ld+ +
  EFC36382.1 89 KLISLDIGC 97
                788999975 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0043
       LRR_6   3 thLteLdLsgNdIg 16 
                 t L++Ld+s N I+
  EFC36382.1 137 TDLRKLDISNNPIS 150
                 679********996 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 2.7
       LRR_6   3 thLteLdL 10 
                  ++t+Ld+
  EFC36382.1 169 LTVTYLDM 176
                 47788886 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.097
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                  Lt+L++ gN +g eG++
  EFC36382.1 189 FLTSLSIYGNLVGIEGVK 206
                 69***********99997 PP

  == domain 6  score: 14.0 bits;  conditional E-value: 1.3e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L++Ld++ N Ig eGa+ ++
  EFC36382.1 214 LKKLDITLNAIGEEGAKLIS 233
                 9***************9985 PP

  == domain 7  score: 18.4 bits;  conditional E-value: 5.1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +L + +N+IgD+Gae+++
  EFC36382.1 239 LNTLRIGDNQIGDKGAESIS 258
                 89***************996 PP

  == domain 8  score: 11.8 bits;  conditional E-value: 6.6e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt+LdL   +Ig +G+e ++
  EFC36382.1 261 KTLTALDLEESNIGPQGLEFIC 282
                 69*****************987 PP

  == domain 9  score: 2.3 bits;  conditional E-value: 0.076
       LRR_6   5 LteLdLsgNdIgD 17 
                 L++L L++N Ig+
  EFC36382.1 287 LKSLMLNFNTIGG 299
                 99*********97 PP

  == domain 10  score: 2.3 bits;  conditional E-value: 0.075
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 t+Lte +L   +Ig e +++++
  EFC36382.1 308 TNLTEISLVLTNIGIEIVKSIS 329
                 89************99999885 PP

  == domain 11  score: 9.5 bits;  conditional E-value: 0.00035
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 t+L+ +++s+N +gDe
  EFC36382.1 332 TKLRNVNISDNRLGDE 347
                 68*************8 PP

  == domain 12  score: 8.8 bits;  conditional E-value: 0.00061
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 +LteLd+s N+++  G
  EFC36382.1 358 NLTELDISENNMTENG 373
                 8**********98766 PP

  == domain 13  score: 5.2 bits;  conditional E-value: 0.009
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt+L+  +N ++De ++ L+
  EFC36382.1 381 KNLTHLNAEDNRLNDESIQHLC 402
                 58****************9998 PP

  == domain 14  score: 11.4 bits;  conditional E-value: 9e-05
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                  +L++L ++ N++gDeG
  EFC36382.1 405 KKLKSLYINNNQVGDEG 421
                 58**************9 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1     0.066     2e+02      21      36 ..      62      76 ..      52      83 .. 0.69
   2 !    7.4   0.4     0.002       6.1       1      39 [.      64     102 ..      64     110 .. 0.79
   3 ?    2.8   0.1     0.057   1.7e+02       2      33 ..      89     121 ..      88     131 .. 0.83
   4 !   10.2   3.0   0.00026      0.79       3      28 ..     139     166 ..     119     188 .. 0.64
   5 ?    4.8   0.3     0.013        40      16      33 ..     178     198 ..     172     206 .. 0.70
   6 !    9.4   0.4   0.00048       1.4       3      38 ..     214     251 ..     213     253 .. 0.83
   7 !    8.3   0.2    0.0011       3.2       2      33 ..     238     272 ..     237     280 .. 0.78
   8 !   11.4   2.4   0.00011      0.33       2      34 ..     286     320 ..     285     331 .. 0.82
   9 ?    5.1   0.5     0.011        33      22      37 ..     331     345 ..     319     354 .. 0.67
  10 !   19.0   4.2   4.6e-07    0.0014       2      38 ..     358     395 ..     357     403 .. 0.86
  11 !   16.8   0.2   2.2e-06    0.0066       1      39 [.     405     445 ..     405     451 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.066
                H-TT--EEE-.-S--- CS
       LRR_4 21 klpnLkeLdLsgNnli 36
                +l++Lk++ L +N +i
  EFC36382.1 62 SLTQLKSIVLKFN-NI 76
                3899999989666.33 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.002
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L+++ L  N++ + +   ++++ +L +Ld+ g+   t+l
  EFC36382.1  64 TQLKSIVLKFNNINEYEMesIASMNKLISLDI-GC-ARTNL 102
                 689************99976668********9.76.33344 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.057
                 S--EEE--..SS---E-S-HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLs..nNqltdiplleklpnLkeLdLsgN 33 
                 +L++Ld++   ++l  i  l++ +n +eL++ ++
  EFC36382.1  89 KLISLDIGcaRTNLEGIKILSSKDNFTELNI-EF 121
                 6899999977899******999999****99.33 PP

  == domain 4  score: 10.2 bits;  conditional E-value: 0.00026
                 --EEE--SS---E-S-..HHH.-TT--EE CS
       LRR_4   3 LevLdLsnNqltdipl..lek.lpnLkeL 28 
                 L++Ld+snN ++        + l++L++L
  EFC36382.1 139 LRKLDISNNPISLNRAksA-NyLKSLEKL 166
                 7778888877774444531.224444444 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.013
                 -S-HH...H-TT--EEE-.-S CS
       LRR_4  16 iplle...klpnLkeLdLsgN 33 
                 +++l+   +l+ L++L++ gN
  EFC36382.1 178 LEFLKsisNLKFLTSLSIYGN 198
                 444333325999999999988 PP

  == domain 6  score: 9.4 bits;  conditional E-value: 0.00048
                 --EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4   3 LevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38 
                 L++Ld+  N + + +     ++l++L +L + g n+i+d
  EFC36382.1 214 LKKLDITLNAIGEEGAkliSNSLKQLNTLRI-GDNQIGD 251
                 999****88***9888974446*********.7669976 PP

  == domain 7  score: 8.3 bits;  conditional E-value: 0.0011
                 S--EEE--SS---E-S-..HHH-TT--EEE-..-S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdL.sgN 33 
                 +L +L +++Nq+ d +   +++++ L+ LdL  +N
  EFC36382.1 238 QLNTLRIGDNQIGDKGAesISSMKTLTALDLeESN 272
                 799**********977765447999******4334 PP

  == domain 8  score: 11.4 bits;  conditional E-value: 0.00011
                 S--EEE--SS---E-S-HHH.-TT--EEE-..-S- CS
       LRR_4   2 nLevLdLsnNqltdipllek.lpnLkeLdL.sgNn 34 
                 +L++L L+ N +    l+ + l+nL+e++L   N 
  EFC36382.1 286 QLKSLMLNFNTIGGSRLPINaLTNLTEISLvLTNI 320
                 69************9997777********855564 PP

  == domain 9  score: 5.1 bits;  conditional E-value: 0.011
                 -TT--EEE-.-S---- CS
       LRR_4  22 lpnLkeLdLsgNnlit 37 
                 +++L+ +++s+N +++
  EFC36382.1 331 ITKLRNVNISDN-RLG 345
                 666666666555.443 PP

  == domain 10  score: 19.0 bits;  conditional E-value: 4.6e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 nL++Ld+s N++t+ +   l++l+nL++L+  +N +++d
  EFC36382.1 358 NLTELDISENNMTENGTkyLSSLKNLTHLNAEDN-RLND 395
                 9*************99999889********9666.6643 PP

  == domain 11  score: 16.8 bits;  conditional E-value: 2.2e-06
                 SS--EEE--SS---E-S-..HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitdl 39 
                 ++L++L+++nNq+ d ++  +++ +++L+ ++  +Nn+ t +
  EFC36382.1 405 KKLKSLYINNNQVGDEGFalIANsMKQLRLVHA-HNNKETEI 445
                 69*************999963344999999988.77776665 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.2   5.6e-06     0.017      22      56 ..      61      95 ..      56      97 .. 0.81
   2 !   10.4   0.3   0.00014      0.41      19      54 ..     131     166 ..     112     174 .. 0.72
   3 !    5.7   2.4    0.0043        13       3      30 ..     139     166 ..     137     200 .. 0.75
   4 !   21.3   0.5   5.8e-08   0.00017       2      60 ..     213     272 ..     212     273 .. 0.95
   5 ?    2.8   4.5     0.034     1e+02       2      61 .]     286     344 ..     285     344 .. 0.85
   6 !   23.6   6.6   1.1e-08   3.2e-05       2      61 .]     333     393 ..     332     393 .. 0.98
   7 !   24.0   8.3   7.9e-09   2.3e-05       2      60 ..     358     416 ..     357     417 .. 0.98

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 5.6e-06
                TT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8 22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56
                ++l++Lk++ L+ N+++  + ++++++++L sLd+
  EFC36382.1 61 SSLTQLKSIVLKFNNINEYEMESIASMNKLISLDI 95
                67888999999999999999999999999888875 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00014
                 TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8  19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsL 54 
                 e  ++++ L+ Ld+snN ++  ++++   L+sL++L
  EFC36382.1 131 EYVSKMTDLRKLDISNNPISLNRAKSANYLKSLEKL 166
                 556778999999999998888777777777777776 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0043
                 -SEEE-TTS--SEE-TTSSTT-TT--EE CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvL 30 
                 L++Ld+snN ++  + ++ + l++L+ L
  EFC36382.1 139 LRKLDISNNPISLNRAKSANYLKSLEKL 166
                 5666666666666666666666666655 PP

  == domain 4  score: 21.3 bits;  conditional E-value: 5.8e-08
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +L++Ld++ N + + + +  ++ l++L++L +++N++    ++++s+++ L+ LdL+  +
  EFC36382.1 213 QLKKLDITLNAIGEEGAKLISNsLKQLNTLRIGDNQIGDKGAESISSMKTLTALDLEESN 272
                 69******************************************************9755 PP

  == domain 5  score: 2.8 bits;  conditional E-value: 0.034
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+sL+L++N + + +    + l+nL++++L   ++     +++s  ++Lr  ++s+NrL
  EFC36382.1 286 QLKSLMLNFNTIGGSRL-PINALTNLTEISLVLTNIGIEIVKSISLITKLRNVNISDNRL 344
                 69999999999988555.445599********9999995579****************98 PP

  == domain 6  score: 23.6 bits;  conditional E-value: 1.1e-08
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+++++s+Nrl + + e   + l nL++Ld+s+N++t    + +s+L++L++L+ ++NrL
  EFC36382.1 333 KLRNVNISDNRLGDECLEIIGNsLFNLTELDISENNMTENGTKYLSSLKNLTHLNAEDNRL 393
                 79********************9************************************98 PP

  == domain 7  score: 24.0 bits;  conditional E-value: 7.9e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 nLt+Ld+s N+ t+ + +  ++l+nL++L+  +N+l+  s + + +L++L+sL++++N+
  EFC36382.1 358 NLTELDISENNMTENGTKYLSSLKNLTHLNAEDNRLNDESIQHLCSLKKLKSLYINNNQ 416
                 8*********************************************************8 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       4.1   1.2e+04       1       8 [.      89      96 ..      89     107 .. 0.79
   2 ?   -1.3   0.0         2   5.9e+03       3      14 ..     115     126 ..     113     128 .. 0.78
   3 !    8.8   0.2   0.00094       2.8       2      13 ..     139     153 ..     138     169 .. 0.75
   4 ?   -2.9   0.0         6   1.8e+04       2      10 ..     190     198 ..     189     202 .. 0.84
   5 ?    3.8   0.0     0.042   1.2e+02       2      21 ..     239     258 ..     213     260 .. 0.69
   6 ?   -1.4   0.0       2.1   6.2e+03       2      12 ..     263     274 ..     262     280 .. 0.67
   7 ?    2.3   0.2      0.13     4e+02       1      23 []     286     310 ..     286     310 .. 0.87
   8 ?    3.1   0.4     0.071   2.1e+02       1      13 [.     333     347 ..     333     356 .. 0.77
   9 ?    3.7   0.1     0.047   1.4e+02       1      12 [.     358     369 ..     358     381 .. 0.80
  10 !    6.4   1.2     0.006        18       1      23 []     382     404 ..     382     404 .. 0.91
  11 !    6.4   0.0    0.0058        17       1      14 [.     406     423 ..     406     432 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 4.1
       LRR_1  1 nLrhLdLs 8 
                +L +Ld++
  EFC36382.1 89 KLISLDIG 96
                78999993 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 2
       LRR_1   3 rhLdLsnnpllg 14 
                 ++L+++  ++++
  EFC36382.1 115 TELNIEFSFFDQ 126
                 79***9999866 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00094
       LRR_1   2 LrhLdLsnnpl...l 13 
                 Lr+Ld+snnp+    
  EFC36382.1 139 LRKLDISNNPIslnR 153
                 9*********84443 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 6
       LRR_1   2 LrhLdLsnn 10 
                 L++L + +n
  EFC36382.1 190 LTSLSIYGN 198
                 899999988 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.042
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L +L +++n++++++++s++
  EFC36382.1 239 LNTLRIGDNQIGDKGAESIS 258
                 44566788888777777776 PP

  == domain 6  score: -1.4 bits;  conditional E-value: 2.1
       LRR_1   2 LrhLdL.snnpl 12 
                 L+ LdL ++n++
  EFC36382.1 263 LTALDLeESNIG 274
                 8899*9555554 PP

  == domain 7  score: 2.3 bits;  conditional E-value: 0.13
       LRR_1   1 nLrhLdLsnnpl..lglppnsfqnL 23 
                 +L++L L+ n +  ++lp+n++ nL
  EFC36382.1 286 QLKSLMLNFNTIggSRLPINALTNL 310
                 599********88899999999876 PP

  == domain 8  score: 3.1 bits;  conditional E-value: 0.071
       LRR_1   1 nLrhLdLsnnpl..l 13 
                 +Lr  ++s+n+l  +
  EFC36382.1 333 KLRNVNISDNRLgdE 347
                 799********9432 PP

  == domain 9  score: 3.7 bits;  conditional E-value: 0.047
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++Ld+s n+ 
  EFC36382.1 358 NLTELDISENNM 369
                 8******99985 PP

  == domain 10  score: 6.4 bits;  conditional E-value: 0.006
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+hL+ ++n+l + +++++++L
  EFC36382.1 382 NLTHLNAEDNRLNDESIQHLCSL 404
                 8***********99999999876 PP

  == domain 11  score: 6.4 bits;  conditional E-value: 0.0058
       LRR_1   1 nLrhLdLsnnpl....lg 14 
                 +L++L+++nn+     + 
  EFC36382.1 406 KLKSLYINNNQVgdegFA 423
                 7*********96333344 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.2     0.015        46      77     118 ..      53      93 ..      37     101 .. 0.77
   2 !    5.3   1.1    0.0043        13      55     125 ..     128     200 ..     106     221 .. 0.71
   3 !   12.8   2.2   2.1e-05     0.062      38     146 ..     233     341 ..     228     344 .. 0.88
   4 !    7.8   1.9   0.00072       2.1      56     123 ..     324     391 ..     317     397 .. 0.85
   5 !    6.9   0.2    0.0014       4.1      56      78 ..     397     419 ..     387     448 .. 0.66

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.015
       LRR_9  77 vriaegleevlPnleelvltnnelqeladldPlaslkklell 118
                 +    +l  +l +l+++vl  n+++e  +++ +as++kl +l
  EFC36382.1  53 CCHHTKLVSSLTQLKSIVLKFNNINEY-EMESIASMNKLISL 93 
                 4455678889999***********996.67999999998776 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0043
       LRR_9  55 rkldgfPllkrlktlllnnnrivriaegleevlPnleelv.ltnnelq.eladldPlaslkklellsllknpv 125
                   ++ +  +  l+ l ++nn i     + +++l +le+l  lt   l+ +l  l+ + +lk l++ls+  n v
  EFC36382.1 128 PYMEYVSKMTDLRKLDISNNPISLNRAKSANYLKSLEKLTdLTVTYLDmDLEFLKSISNLKFLTSLSIYGNLV 200
                 4455555677899999******988888888888888875466666542677788888888888888888876 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 2.1e-05
       LRR_9  38 Gatldqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrly 134
                   +l q++t+ + dn+i  +  +++  +k l +l l++  i   + ++   + +l++l+l+ n++       P+  l +l+ +sl+ + +  +      
  EFC36382.1 233 SNSLKQLNTLRIGDNQIgdKGAESISSMKTLTALDLEESNIGPQGLEFICQMDQLKSLMLNFNTIGGS--RLPINALTNLTEISLVLTNIGIEIVKSIS 329
                 56899************5555899*****************99999999999*************964..46*************99999888888889 PP

       LRR_9 135 viyklkqlrlld 146
                 +i kl+++ + d
  EFC36382.1 330 LITKLRNVNISD 341
                 999999998876 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.00072
       LRR_9  56 kldgfPllkrlktlllnnnriv.riaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                  + ++ l+ +l+ + +++nr+     e ++++l nl+el +++n+++e ++ + l slk+l+ l   +n
  EFC36382.1 324 IVKSISLITKLRNVNISDNRLGdECLEIIGNSLFNLTELDISENNMTENGT-KYLSSLKNLTHLNAEDN 391
                 5677889999**********9725678899******************999.99*******99976665 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0014
       LRR_9  56 kldgfPllkrlktlllnnnrivr 78 
                  ++ +  lk+lk+l++nnn++  
  EFC36382.1 397 SIQHLCSLKKLKSLYINNNQVGD 419
                 3556778999********99854 PP

>> HTH_26  Cro/C1-type HTH DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   9.8e-05      0.29      21      51 ..      10      38 ..       3      40 .. 0.91
   2 ?   -1.8   0.0       1.5   4.3e+03      26      26 ..     382     382 ..     361     404 .. 0.49

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.8e-05
      HTH_26 21 gisaatlsrlvkgkpervsldtLdkiCdaLg 51
                 i + +++rlv g+  r++ + +++iC++L+
  EFC36382.1 10 HIKSWQIKRLVRGT--RLDKEKMERICKILK 38
                68999********9..*************96 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.5
      HTH_26  26 t 26 
                 +
  EFC36382.1 382 N 382
                 3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (467 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2967.15
//
Query:       EFC36383.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.8e-32  109.3   1.2    6.3e-23   80.9   0.1    2.2  2  DUF4476   Domain of unknown function (DUF4476)
     0.0083   16.1   0.2       0.91    9.6   0.0    2.8  3  Bromo_TP  Bromodomain associated
  ------ inclusion threshold ------
      0.044   13.9   0.4       0.96    9.6   0.1    3.0  4  Clp_N     Clp amino terminal domain, pathogenicity island com


Domain annotation for each model (and alignments):
>> DUF4476  Domain of unknown function (DUF4476)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   0.1     5e-12     3e-08       5      61 ..      41      99 ..      37     102 .. 0.88
   2 !   80.9   0.1     1e-26   6.3e-23       2      91 .]      71     164 ..      70     164 .. 0.93

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 5e-12
     DUF4476  5 ksfeqlveklkkasfdddklklleq.alank.aftcsqvvqllklfsfdddrlkalkll 61
                +  +q+++   +asfd+dk+k++++ ++a++  ++ + +v++l+lf fd+d++ +l  l
  EFC36383.1 41 SLARQIIQACENASFDNDKVKAVQTySSAQCcPINGADLVTILDLFGFDNDKITVLSQL 99
                557899*******************7556668***********************9876 PP

  == domain 2  score: 80.9 bits;  conditional E-value: 1e-26
     DUF4476   2 msdksfeqlveklkkasfdddklklleq.alank..aftcsqvvqllklfsfdddrlkalkllapnivDkqns.etiidsftfssdkkkareil 91 
                 +++ +  +lv++l+ + fd+dk+++l+q + +n+  +++c++++q+l+ f fd+d+lkal+ll  +i+D+++  eti+  f f++d++kar il
  EFC36383.1  71 CCPINGADLVTILDLFGFDNDKITVLSQlRNTNNifQMNCNEAAQVLESFGFDNDKLKALELLLISIYDRKQHaETIVGGFGFDNDQSKARTIL 164
                 8889999********************96555559***********************************8888*****************997 PP

>> Bromo_TP  Bromodomain associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.014        82       5      31 ..      39      65 ..      35      70 .. 0.78
   2 ?   -1.3   0.0      0.38   2.3e+03      15      33 ..      82     100 ..      78     106 .. 0.77
   3 !    9.6   0.0   0.00015      0.91      12      33 ..     113     134 ..     105     139 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.014
                HHHHHHHHHHHHHHHT-SEE-HHHHHH CS
    Bromo_TP  5 rsllkvvvsqileeaGfdsaeesaLEt 31
                 + l + + q++e+a fd+ +  a+ t
  EFC36383.1 39 NNSLARQIIQACENASFDNDKVKAVQT 65
                55556666799********99999887 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.38
                 HHHHHT-SEE-HHHHHHHH CS
    Bromo_TP  15 ileeaGfdsaeesaLEtLt 33 
                 il   Gfd+ +  +L  L+
  EFC36383.1  82 ILDLFGFDNDKITVLSQLR 100
                 7778899998888887776 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00015
                 HHHHHHHHT-SEE-HHHHHHHH CS
    Bromo_TP  12 vsqileeaGfdsaeesaLEtLt 33 
                 ++q+le+ Gfd+ +  aLE+L 
  EFC36383.1 113 AAQVLESFGFDNDKLKALELLL 134
                 69*****************995 PP

>> Clp_N  Clp amino terminal domain, pathogenicity island component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.14   8.1e+02      27      37 ..      40      50 ..      39      62 .. 0.83
   2 ?   -2.0   0.0      0.66     4e+03      33      44 ..      82      93 ..      78      94 .. 0.83
   3 ?    9.6   0.1   0.00016      0.96      29      46 ..     112     129 ..     111     134 .. 0.89
   4 ?   -2.1   0.0      0.76   4.5e+03      16      43 ..     131     157 ..     129     163 .. 0.54

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.14
                TSHHHHHHHHT CS
       Clp_N 27 dGlaarlLkka 37
                ++la+++++++
  EFC36383.1 40 NSLARQIIQAC 50
                67999999987 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.66
                HHHHTTSSHHHH CS
       Clp_N 33 lLkkaGvdldal 44
                +L  +G+d d++
  EFC36383.1 82 ILDLFGFDNDKI 93
                89999***9987 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00016
                 HHHHHHHHTTSSHHHHHH CS
       Clp_N  29 laarlLkkaGvdldalrk 46 
                  aa++L+ +G+d d+l++
  EFC36383.1 112 EAAQVLESFGFDNDKLKA 129
                 59**********999985 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 0.76
                 HHHHHHHHHSCTSHHHHHHHHTTSSHHH CS
       Clp_N  16 EHLLlALleeddGlaarlLkkaGvdlda 43 
                 E LL+++++ ++  a  +   +G+d d+
  EFC36383.1 131 ELLLISIYDRKQ-HAETIVGGFGFDNDQ 157
                 556666555442.444444555666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       955  (0.0532657); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1102.10
//
Query:       EFC36384.1  [L=107]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.062   13.3   0.0       0.12   12.4   0.0    1.5  1  Hum_adeno_E3A  Human adenovirus early E3A glycoprotein


Domain annotation for each model (and alignments):
>> Hum_adeno_E3A  Human adenovirus early E3A glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   6.6e-06      0.12      62      98 ..      51      87 ..      41      89 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.6e-06
  Hum_adeno_E3A 62 lkrkrarppiykpiivlnpnnekihrldglktcslll 98
                    k k+   p+y+pi+ l    e++  l    tcs+ +
     EFC36384.1 51 KKYKQKAVPVYQPIVELTVGAEDLNVLKDETTCSFFF 87
                   56778889**************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (107 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       430  (0.0239835); expected 358.6 (0.02)
Passed bias filter:                      258  (0.0143901); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.47
# Mc/sec: 685.91
//
Query:       EFC36385.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-08   35.3  53.0     0.0074   16.7   8.7    7.5  8  LRR_4     Leucine Rich repeats (2 copies)
    9.4e-05   22.2  36.9     0.0058   16.6   0.5    8.4  8  LRR_6     Leucine Rich repeat
     0.0015   18.8  38.7        9.2    7.3   0.4    9.2  8  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
       0.44   10.4  41.2        3.4    7.5   0.5    6.7  6  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   8.7   1.6e-06    0.0074       2      43 ..       7      48 ..       6      49 .. 0.91
   2 !    6.0   3.7    0.0037        17       1      33 [.      51      85 ..      51      89 .. 0.80
   3 !    5.1   0.2    0.0071        32      16      33 ..      92     108 ..      90     128 .. 0.64
   4 !    6.8   2.9    0.0021       9.5      12      38 ..     136     165 ..      98     171 .. 0.65
   5 !    6.9   0.5    0.0019       8.6       2      33 ..     151     186 ..     151     192 .. 0.58
   6 !   16.4   4.9   2.1e-06    0.0094       2      38 ..     177     217 ..     176     229 .. 0.85
   7 !   15.0   5.1   5.5e-06     0.025       1      41 [.     203     247 ..     203     250 .. 0.70
   8 ?    4.5   1.2     0.011        51       1      33 [.     230     264 ..     230     290 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.6e-06
                S--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4  2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeLk 43
                +Le+L+L +N+l +++  e+lpn  +L++s+N +++d + Lk
  EFC36385.1  7 SLESLNLLGNKLLEVQVGENLPNISHLNISNNFNLSDTSFLK 48
                7****************889*********9998888988876 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0037
                SS--EEE--SS.---E-S-.HHH-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnN.qltdipl.leklpnLkeLdLsgN 33
                p+L++L  + N     ++  l++++ Lk+L+++++
  EFC36385.1 51 PKLTNLEANRNlGFENLNEtLNSMTCLKSLSITQC 85
                79*******86456666668889********9665 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0071
                 -S-HHH-TT--EEE-.-S CS
       LRR_4  16 iplleklpnLkeLdLsgN 33 
                 ++ +  l+nL+ Ld++++
  EFC36385.1  92 LGQPI-LKNLEFLDITDC 108
                 55567.9*******7555 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0021
                 ---E-S-....HHH-TT--EEE-.-S----- CS
       LRR_4  12 qltdipl....leklpnLkeLdLsgNnlitd 38 
                 ++td ++    l+ l nLk+L+++++   +d
  EFC36385.1 136 CITDCEFigngLA-LRNLKHLSINRCKSWWD 165
                 4666666443444.88888888877755555 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0019
                 S--EEE--SS-....--E-S-HH......H-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNq....ltdiplle......klpnLkeLdLsgN 33 
                 nL++L+++ ++           e      ++ nL++L+L ++
  EFC36385.1 151 NLKHLSINRCKswwdF------EkmllgpNMSNLETLSLESC 186
                 5666666663333332......22222345999999999766 PP

  == domain 6  score: 16.4 bits;  conditional E-value: 2.1e-06
                 S--EEE--SS---E-S-HH.....H.-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdiplle.....k.lpnLkeLdLsgNnlitd 38 
                 nLe+L+L ++++  i++++     + l+ L++L+L +Nnli+d
  EFC36385.1 177 NLETLSLESCHIG-IQGCKliaqsStLTRLTKLNL-SNNLIKD 217
                 9************.999444467855*********.6669976 PP

  == domain 7  score: 15.0 bits;  conditional E-value: 5.5e-06
                 SS--EEE--SS---E-S-..HH...H-TT--EEE-.-.S-----GGG CS
       LRR_4   1 pnLevLdLsnNqltdipl..le...klpnLkeLdLsg.Nnlitdlde 41 
                 ++L++L+LsnN ++d +   l    +l +L +Ld+ + N  +t+ + 
  EFC36385.1 203 TRLTKLNLSNNLIKDEGCaiLCqssNLQHLISLDI-SwN-ELTTCSH 247
                 68************966677224546888888888.435.5665555 PP

  == domain 8  score: 4.5 bits;  conditional E-value: 0.011
                 SS--EEE--.SS---E-S-HH..H.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLs.nNqltdiplle..k.lpnLkeLdLsgN 33 
                 ++L++Ld+s n  lt+ + l+  + + nL eL   +N
  EFC36385.1 230 QHLISLDISwN-ELTTCSHLAnnQyFVNLIELKF-EN 264
                 589******76.***9999777866999999987.55 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.3      0.19   8.5e+02       4      14 ..       7      17 ..       5      19 .. 0.85
   2 ?   -0.3   1.1      0.33   1.5e+03       3      13 ..      28      38 ..      26      44 .. 0.79
   3 ?    0.3   0.1      0.21   9.6e+02       3      13 ..      75      85 ..      73      86 .. 0.84
   4 ?    2.7   0.0     0.038   1.7e+02       4      15 ..      99     110 ..      97     111 .. 0.86
   5 ?    1.8   0.2     0.071   3.2e+02       3      14 ..     150     161 ..     148     161 .. 0.87
   6 !   10.6   0.2   0.00011      0.47       2      24 .]     175     197 ..     174     197 .. 0.91
   7 !   16.6   0.5   1.3e-06    0.0058       3      20 ..     203     220 ..     201     224 .. 0.89
   8 !   10.5   0.5   0.00011      0.51       2      16 ..     229     243 ..     228     244 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.19
       LRR_6  4 hLteLdLsgNd 14
                +L++L+L gN+
  EFC36385.1  7 SLESLNLLGNK 17
                79*****9887 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.33
       LRR_6  3 thLteLdLsgN 13
                +++ +L++s N
  EFC36385.1 28 PNISHLNISNN 38
                56779999988 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.21
       LRR_6  3 thLteLdLsgN 13
                t+L++L+++ +
  EFC36385.1 75 TCLKSLSITQC 85
                89*****9976 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.038
       LRR_6   4 hLteLdLsgNdI 15 
                 +L+ Ld++++++
  EFC36385.1  99 NLEFLDITDCGF 110
                 7999******86 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.071
       LRR_6   3 thLteLdLsgNd 14 
                 ++L++L+++ ++
  EFC36385.1 150 RNLKHLSINRCK 161
                 79******9995 PP

  == domain 6  score: 10.6 bits;  conditional E-value: 0.00011
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  ++L++L+L +++Ig +G++ +a
  EFC36385.1 175 MSNLETLSLESCHIGIQGCKLIA 197
                 589************99999987 PP

  == domain 7  score: 16.6 bits;  conditional E-value: 1.3e-06
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                 t Lt+L+Ls N I DeG+
  EFC36385.1 203 TRLTKLNLSNNLIKDEGC 220
                 78***************7 PP

  == domain 8  score: 10.5 bits;  conditional E-value: 0.00011
       LRR_6   2 nthLteLdLsgNdIg 16 
                  +hL +Ld+s+N+++
  EFC36385.1 229 LQHLISLDISWNELT 243
                 68**********998 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.6      0.13   5.7e+02       1      12 [.       7      18 ..       7      29 .. 0.77
   2 !    5.9   2.5    0.0056        25       2      20 ..      30      46 ..      29      67 .. 0.78
   3 ?    0.2   0.0      0.44     2e+03       2      10 ..      77      85 ..      76      95 .. 0.86
   4 !    5.7   0.2    0.0066        30       1      13 [.      99     116 ..      99     147 .. 0.82
   5 !    6.3   0.1    0.0042        19       1      12 [.     151     162 ..     151     172 .. 0.82
   6 !    6.8   0.1     0.003        13       1      12 [.     177     188 ..     177     200 .. 0.80
   7 ?    4.6   2.0     0.016        71       1      12 [.     204     215 ..     204     232 .. 0.71
   8 !    7.3   0.4    0.0021       9.2       1      13 [.     231     243 ..     228     264 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.13
       LRR_1  1 nLrhLdLsnnpl 12
                +L++L+L +n l
  EFC36385.1  7 SLESLNLLGNKL 18
                69*****88887 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0056
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                  hL++snn++  l++ sf
  EFC36385.1 30 ISHLNISNNFN--LSDTSF 46
                679*******7..344443 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.44
       LRR_1  2 LrhLdLsnn 10
                L++L ++++
  EFC36385.1 77 LKSLSITQC 85
                99****999 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.0066
       LRR_1   1 nLrhLdLsnnpl.....l 13 
                 nL+ Ld++++ +     +
  EFC36385.1  99 NLEFLDITDCGFsikvmF 116
                 8*********97554443 PP

  == domain 5  score: 6.3 bits;  conditional E-value: 0.0042
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+hL ++++  
  EFC36385.1 151 NLKHLSINRCKS 162
                 8*********86 PP

  == domain 6  score: 6.8 bits;  conditional E-value: 0.003
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L L+++++
  EFC36385.1 177 NLETLSLESCHI 188
                 8*********98 PP

  == domain 7  score: 4.6 bits;  conditional E-value: 0.016
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L+Lsnn +
  EFC36385.1 204 RLTKLNLSNNLI 215
                 699*******98 PP

  == domain 8  score: 7.3 bits;  conditional E-value: 0.0021
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L +Ld+s+n l+
  EFC36385.1 231 HLISLDISWNELT 243
                 46777*****993 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7  12.0    0.0013       5.9       2      59 ..       7      61 ..       6      62 .. 0.86
   2 ?    0.9   1.8     0.085   3.8e+02      17      58 ..      42      84 ..      39      86 .. 0.72
   3 ?   -0.0   0.0      0.17   7.6e+02      25      55 ..      98     130 ..      96     133 .. 0.45
   4 ?    2.5   0.8     0.029   1.3e+02      24      33 ..     175     184 ..     146     188 .. 0.55
   5 ?    6.7   4.9    0.0014       6.3       2      38 ..     177     216 ..     176     217 .. 0.66
   6 ?    7.5   0.5   0.00075       3.4      22      41 ..     227     246 ..     225     252 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0013
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsgN 59
                +L+sL+L  N+l +++    ++l+n  +L++snN +l+  s   + ++p+L+ L  ++N
  EFC36385.1  7 SLESLNLLGNKLLEVQV--GENLPNISHLNISNNfNLSDTS--FLKSFPKLTNLEANRN 61
                79999999999987765..599************9999887..9999999999988888 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.085
                -TTSSTT.-TT--EEE--SS.---GGGGGGGTT--S-.EEE--S CS
       LRR_8 17 ddeaFkg.lsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsg 58
                +d++F + +++L+ L+ ++N   + l+ +++ +++ L+sL +++
  EFC36385.1 42 SDTSFLKsFPKLTNLEANRNlGFENLN-ETLNSMTCLKSLSITQ 84
                555555558899999888886666675.8888888888888776 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.17
                 TT--EEE--SS..---GGGGGGGTT--S-.EEE CS
       LRR_8  25 snLkvLdLsnN..llttlspgafsgLpsLrsLd 55 
                 +nL+ Ld+++   +++++ ++ ++ +++++ L+
  EFC36385.1  98 KNLEFLDITDCgfSIKVMFNNGIDTFSNITRLN 130
                 444444443322245555555555555555555 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.029
                 -TT--EEE-- CS
       LRR_8  24 lsnLkvLdLs 33 
                 +snL++L+L 
  EFC36385.1 175 MSNLETLSLE 184
                 5555555553 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.0014
                 T-SEEE-TTS-..-SEE-TTSSTT.-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNr..ltslddeaFkg.lsnLkvLdLsnNllt 38 
                 nL++L+L + +  +++ +  a ++ l++L+ L+LsnNl++
  EFC36385.1 177 NLETLSLESCHigIQGCKLIAQSStLTRLTKLNLSNNLIK 216
                 5666666666644555555555555999999999999997 PP

  == domain 6  score: 7.5 bits;  conditional E-value: 0.00075
                 TT-TT--EEE--SS---GGG CS
       LRR_8  22 kglsnLkvLdLsnNllttls 41 
                 ++l++L +Ld+s N+ltt s
  EFC36385.1 227 SNLQHLISLDISWNELTTCS 246
                 68***************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       374  (0.0208601); expected 358.6 (0.02)
Passed bias filter:                      236  (0.013163); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1670.04
//
Query:       EFC36386.1  [L=583]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.2e-08   34.3   0.6    2.2e-08   34.3   0.6    2.8  3  DNMT1-RFD  Cytosine specific DNA methyltransferase replicatio
  ------ inclusion threshold ------
        5.4    7.1   6.8        3.5    7.7   0.5    3.1  2  RHH_1      Ribbon-helix-helix protein, copG family


Domain annotation for each model (and alignments):
>> DNMT1-RFD  Cytosine specific DNA methyltransferase replication foci domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.3   0.6   2.4e-12   2.2e-08       9     116 ..      30     130 ..      24     161 .. 0.88
   2 ?   -2.8   0.9      0.65   5.9e+03      34      34 ..     276     276 ..     231     308 .. 0.53
   3 ?   -3.1   2.2      0.84   7.5e+03      19      61 ..     344     386 ..     338     394 .. 0.63

  Alignments for each domain:
  == domain 1  score: 34.3 bits;  conditional E-value: 2.4e-12
                 EEEEEEEETTSBB--STTSTTTTT--EEEEEEEEETT.----SSTT.SEEEEE....ES-ECEEEEEECSSSSBEEEEEEESS-EEEE-SB-TTTHHHH CS
   DNMT1-RFD   9 ltdfelydkdgelvslevleieknadifisgvvkdidsedeekkkekgiedkglqiklgpIkeWtisgvdegekalivlsTetadYkLlkPsaeYapiy 107
                 lt+fe++d+++++        ek++ ++++g++ + + e +++++ekg+   +    + +  +W+ +  de   + i++ +++ ++kL kP  e++ iy
  EFC36386.1  30 LTNFEFRDSRTTSLKSPEFITEKGVSLMLTGYLLTPE-EYKSSPDEKGEYFVK----IVNLRQWAFDHEDET--RGIWVESKRHWFKLIKPTREFKVIY 121
                 89*******99877766688999**********8888.788999996766666....9******99996655..8************************ PP

                 HHHHHHHHH CS
   DNMT1-RFD 108 ekviekarl 116
                 e++ +k ++
  EFC36386.1 122 ESFEKKSNI 130
                 *****9887 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.65
                 - CS
   DNMT1-RFD  34 d 34 
                 +
  EFC36386.1 276 E 276
                 2 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 0.84
                 SBB--STTSTTTTT--EEEEEEEEETT.----SSTT.SEEEEE CS
   DNMT1-RFD  19 gelvslevleieknadifisgvvkdidsedeekkkekgiedkg 61 
                  + + +e    +k  +  is+   d+d++ +e+++e ++e+++
  EFC36386.1 344 ENQKEIEKVTPKKRKESTISRETNDDDEDFNESEEEYSSENGK 386
                 4555666666666777788888888885445666665655555 PP

>> RHH_1  Ribbon-helix-helix protein, copG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.5   0.00039       3.5       6      29 ..     489     512 ..     486     518 .. 0.89
   2 ?    1.1   0.9     0.048   4.3e+02       7      26 ..     524     543 ..     522     554 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00039
                 EEHHHHHHHHHHHHHHTSSHHHHH CS
       RHH_1   6 ldeellerLdelarrrgrSrSelI 29 
                   +el++++de +++ ++S S+++
  EFC36386.1 489 ALKELYAKIDEEKAAKEQSSSDIL 512
                 5689*****************996 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.048
                 EHHHHHHHHHHHHHHTSSHH CS
       RHH_1   7 deellerLdelarrrgrSrS 26 
                 + e++e ++e+ ++++r+r 
  EFC36386.1 524 EPEEVEIVEEHNEELERNRE 543
                 5799************9996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (583 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2744  (0.153048); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        97  (0.00541023); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.92u 0.34s 00:00:01.26 Elapsed: 00:00:00.50
# Mc/sec: 3486.92
//
Query:       EFC36387.1  [L=482]
Description: hypothetical protein NAEGRDRAFT_82236 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.3e-14   52.7   0.4    6.4e-14   51.3   0.4    1.8  1  SH3_1        SH3 domain
    1.2e-13   50.7   0.8    1.2e-13   50.7   0.8    2.0  2  SH3_9        Variant SH3 domain
    2.3e-12   46.8   0.1    2.3e-12   46.8   0.1    2.1  2  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
    4.3e-12   45.5   0.1    1.3e-11   44.0   0.0    1.8  2  SH3_2        Variant SH3 domain
  ------ inclusion threshold ------
      0.081   12.8   0.0       0.19   11.6   0.0    1.6  1  SH3_4        Bacterial SH3 domain


Domain annotation for each model (and alignments):
>> SH3_1  SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.3   0.4   1.8e-17   6.4e-14       1      48 []     430     475 ..     430     475 .. 0.93

  Alignments for each domain:
  == domain 1  score: 51.3 bits;  conditional E-value: 1.8e-17
                 EESSSBEXSSTTBXEBSTTEEEEEEEECSSSEEEEEETTSTEEEEEEG CS
       SH3_1   1 iAlYDYeaeesdELsfkkGDviivleksedgWwkgrlkgtgkeGliPs 48 
                 +A +D+e+++ +ELsf +GD++ +++++ + Ww +++++ g++G+iPs
  EFC36387.1 430 VAVFDFEGQDGEELSFAEGDTLYLVQDEGE-WWLAEDTN-GQQGYIPS 475
                 699***********************6655.*******9.6******8 PP

>> SH3_9  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1         1   3.6e+03      27      39 ..     204     216 ..     201     220 .. 0.72
   2 !   50.7   0.8   3.2e-17   1.2e-13       1      49 []     431     479 ..     431     479 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1
       SH3_9  27 sedgWlegsltGr 39 
                 +++ +++g+ t++
  EFC36387.1 204 ERNQFWQGQSTST 216
                 5789****98553 PP

  == domain 2  score: 50.7 bits;  conditional E-value: 3.2e-17
       SH3_9   1 AlypyepreddeLsLqrGDvitvieesedgWlegsl.tGrtGlvPanyve 49 
                 A++++e ++ +eLs+ +GD++++ ++ e+ W++++  +G+ G+ P+nyve
  EFC36387.1 431 AVFDFEGQDGEELSFAEGDTLYLVQD-EGEWWLAEDtNGQQGYIPSNYVE 479
                 89************************.********88************7 PP

>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.8   0.1   6.5e-16   2.3e-12       2     120 ..      11     125 ..      10     126 .. 0.90
   2 ?   -1.5   0.6      0.59   2.1e+03      15      44 ..     152     183 ..     140     193 .. 0.53

  Alignments for each domain:
  == domain 1  score: 46.8 bits;  conditional E-value: 6.5e-16
                  HHHHHHHCTTT.SSEEEEEEECTTTEEEEEESS-HHHHHHHHHHTTT-EEEEEEEEEECCSECCEEEEEEEEE--TT.S-HHHHHHHHHHHHHHHHHC CS
  Cofilin_ADF   2 keafkelksgkktkyilfkidddkeeivveeegetyeelreelpeseprYavydveyehddeskrsklvfIswvPds.apikqkmlyasskdalkkel 98 
                  k+af++++++k  +y+l+k ++ +++++v ++g+++ +l+++l+++ ++Ya++++  ++      +k+v++ w+P++ a+   k ++    +++   l
   EFC36387.1  11 KQAFDDVSNSK-LTYALLKHEGTSNKVIVASTGDDILDLIDDLNDGTIMYALIRFVINDA-----TKFVYVGWCPEGiANQIFKGKFQNWNKDMEFYL 102
                  89******988.99****************************************996544.....7**********637899*************999 PP

                  TTSEE.EEEE-CGGCCSHHHHHH CS
  Cofilin_ADF  99 kgisv.eieatdldelteeelke 120
                  kg  + ++ a++++++++ ++ +
   EFC36387.1 103 KGRYHlSVYARNEEDIDQASWIK 125
                  8766549*********9987766 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.59
                  SEEEEEEECTTTEEEEEE..SS-HHHHHHHHH CS
  Cofilin_ADF  15 kyilfkidddkeeivvee..egetyeelreel 44 
                  + +  k d +k+e+ +++  +++ +e+ +eel
   EFC36387.1 152 NIASSKTDVKKTEVAIDDseRNKFWEKQQEEL 183
                  44444555555566665532222444444444 PP

>> SH3_2  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.9     7e+03      33      42 ..     204     213 ..     198     215 .. 0.69
   2 !   44.0   0.0   3.5e-15   1.3e-11       3      55 ..     430     479 ..     429     480 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.9
                 ECTTEEEEEE CS
       SH3_2  33 dsdgwwegev 42 
                 +++ +w+g++
  EFC36387.1 204 ERNQFWQGQS 213
                 56689*9975 PP

  == domain 2  score: 44.0 bits;  conditional E-value: 3.5e-15
                 EESS-B-SCGCCB--B-TTEEEEEE..EEEECTTEEEEEE.CCCEEEEEGCGEE CS
       SH3_2   3 raiedyvgedkseLsfkkGdvikvlslgskdsdgwwegev.gGrvGlfPsslve 55 
                 +a++d++g+d +eLsf +Gd+++++    +d ++ww++e  +G++G++Ps++ve
  EFC36387.1 430 VAVFDFEGQDGEELSFAEGDTLYLV----QDEGEWWLAEDtNGQQGYIPSNYVE 479
                 79***********************....*********988************7 PP

>> SH3_4  Bacterial SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   5.2e-05      0.19      28      51 ..     452     475 ..     444     479 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.2e-05
       SH3_4  28 rvvackgnWcrvrDadGatGWiyq 51 
                  +v+ +g+W  ++D++G++G+i +
  EFC36387.1 452 YLVQDEGEWWLAEDTNGQQGYIPS 475
                 578999****************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (482 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1862  (0.103854); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.48
# Mc/sec: 3049.87
//
Query:       EFC36388.1  [L=76]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.2e-31  106.5   0.4    4.6e-31  106.4   0.4    1.0  1  ubiquitin    Ubiquitin family
      2e-15   56.4   0.3    2.2e-15   56.2   0.3    1.0  1  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
    0.00036   20.9   0.2     0.0016   18.9   0.2    1.8  1  Ubiquitin_2  Ubiquitin-like domain
     0.0048   16.8   0.0     0.0051   16.7   0.0    1.2  1  TBK1_ULD     TANK binding kinase 1 ubiquitin-like domain
  ------ inclusion threshold ------
      0.014   15.5   0.0       0.03   14.4   0.0    1.6  1  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
      0.021   14.8   0.5        1.4    9.0   0.2    2.0  2  Ubiquitin_4  Ubiquitin-like domain
      0.036   14.4   0.1      0.043   14.2   0.1    1.1  1  Ubiquitin_5  Ubiquitin-like domain
      0.087   13.1   0.0        0.1   12.8   0.0    1.1  1  TUG-UBL1     TUG ubiquitin-like domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  106.4   0.4   2.1e-34   4.6e-31       1      72 []       3      74 ..       3      74 .. 0.99

  Alignments for each domain:
  == domain 1  score: 106.4 bits;  conditional E-value: 2.1e-34
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                ++vktl+g++itleve++d++e++K k+++kegi ++qqrLi+ Gk+Led rt+++y++q++stlhlvlrlr
  EFC36388.1  3 LFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISPDQQRLIFGGKQLEDGRTIGDYNLQKDSTLHLVLRLR 74
                79*******************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.2   0.3   9.8e-19   2.2e-15       1      72 []       1      71 [.       1      71 [. 0.98

  Alignments for each domain:
  == domain 1  score: 56.2 bits;  conditional E-value: 9.8e-19
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                +++++k+ +g +++++V+++  +++++++ ++k+gi++ +++rLiF G++L++  t++d+ +++++t+++v+
  EFC36388.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISP-DQQRLIFGGKQLEDGRTIGDYNLQKDSTLHLVL 71
                89************************************.******************************996 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.2   7.1e-07    0.0016      17      79 ..      14      68 ..       2      70 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 7.1e-07
                 EEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2 17 errfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79
                 +  ++++++ie++K+k++   G+sp+++rL +          k  +d ++ g+Y+++  +++h
   EFC36388.1 14 TLEVESNDSIENVKRKVQDKEGISPDQQRLIFG--------GKQLEDGRTIGDYNLQKDSTLH 68
                 56678899**********************998........4555788888888888888887 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.3e-06    0.0051      19      52 ..      17      50 ..       6      70 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.3e-06
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrl 52
                +++++ ++++  +v+++  i++++Q l+f g++l
  EFC36388.1 17 VESNDSIENVKRKVQDKEGISPDQQRLIFGGKQL 50
                678999**************************97 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.0   1.3e-05      0.03      17      87 ..      14      71 ..       2      74 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.3e-05
                 EEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2 17 pvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87
                  ++ +++++++++k+kv      dke    s+++ +li  Gk Le+ +t+++++l+         ++H+v+
   EFC36388.1 14 TLEVESNDSIENVKRKVQ-----DKEG--ISPDQQRLIFGGKQLEDGRTIGDYNLQKDS------TLHLVL 71
                 566777888888888884.....4444..567778*****************9655433......466665 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.2   0.00064       1.4       1      33 [.       1      33 [.       1      42 [. 0.91
   2 ?    4.9   0.0     0.012        27      58      86 ..      43      70 ..      39      73 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00064
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaierk 33
                 +++ vk l g+++ ++v++n +++++k+ ++ k
   EFC36388.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDK 33
                 78999*************************976 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.012
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L+f g++L+ d  ++ +y ++++s+l+ v
   EFC36388.1 43 LIFGGKQLE-DGRTIGDYNLQKDSTLHLV 70
                 788888885.6789***********9976 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.1   1.9e-05     0.043      33      92 ..      12      72 ..       4      75 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.9e-05
  Ubiquitin_5 33 kklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLk 92
                   +le++ + + +++ +k+ ++ g+  ++ +li  gk+le ++t+ + +++++s + +vL+
   EFC36388.1 12 TITLEVESNDSIENVKRKVQDKEGISPDQQRLIFGGKQLEDGRTIGDYNLQKDSTLhLVLR 72
                 5567777777889999999999************************999998886535665 PP

>> TUG-UBL1  TUG ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   4.5e-05       0.1       4      65 .]       9      69 ..       7      69 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 4.5e-05
    TUG-UBL1  4 nfrrfkvkvtpnttlndvLeeackkfklddsasytLkhnnkpldlslpfRlsnLpngakLeL 65
                ++r+ +  v  n ++  v  ++  k ++ ++++  L +++k+l+   ++   nL   ++L L
  EFC36388.1  9 TGRTITLEVESNDSIENVKRKVQDKEGI-SPDQQRLIFGGKQLEDGRTIGDYNLQKDSTLHL 69
                68999***********************.888***********9988888888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (76 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       548  (0.030565); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.43u 0.32s 00:00:00.75 Elapsed: 00:00:00.48
# Mc/sec: 477.52
//
Query:       EFC36389.1  [L=280]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-19   69.3   0.1    2.1e-11   44.0   0.0    2.2  2  C2        C2 domain
  ------ inclusion threshold ------
      0.086   12.6   1.0       0.15   11.7   0.3    1.8  2  NT-C2     N-terminal C2 in EEIG1 and EHBP1 proteins


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.1   6.9e-09   6.2e-05      10      93 ..      17     116 ..      10     126 .. 0.81
   2 !   44.0   0.0   2.3e-15   2.1e-11      10      93 ..     158     248 ..     155     261 .. 0.87

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 6.9e-09
                 EESS.SSSSTTSSCEEEEEEEE......ECEEEEEE-SCSSSSSSEEEEEEEEEESC......HTTSEEEEEEEE..ECSS.STEEEEEEEEEEGHHHH CS
          C2  10 AknL.pnkdkkgssdpyvkvsl......dgkqkakTrviknslnPvWnekftfevae......leeakLeveVfd..ndrl.skddfiGkveiplstll 92 
                 +++L +nk+   ++d+++++s+       +k++ +T++ k + nP++ + +++  +       ++ + L++++++  + ++  ++df+G+v +++stl+
  EFC36389.1  17 CHDLkNNKNSITKMDTFCVLSMdnnngdGSKEMDRTEIQKANHNPTYLKPLSIVRSSyvqssvSSLTPLTFSIYHsyFANYkDHEDFLGRVCVNISTLA 115
                 6788556666788**************999999****999999****8888886666778888899*********66455535556**********965 PP

                 T CS
          C2  93 s 93 
                 +
  EFC36389.1 116 H 116
                 4 PP

  == domain 2  score: 44.0 bits;  conditional E-value: 2.3e-15
                 EESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEE.EEEEEEESC..HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHT CS
          C2  10 AknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWn.ekftfevae..leeakLeveVfdndrlskddfiGkveiplstlls 93 
                 + +L++kd +g+sdp+ ++s     +   ++k+++ik++l+P+W+  ++tf+     + +++L+++V+d+d+ +++dfiG + + +++l++
  EFC36389.1 158 GSDLAKKDLFGKSDPFFTISReingRIIDIYKSEIIKKNLDPIWSsFRMTFKSFCngNDNEQLKMSVYDWDSATDSDFIGDCVFTFKELKE 248
                 5799****************9998888899**************6577777555579***************************9999544 PP

>> NT-C2  N-terminal C2 in EEIG1 and EHBP1 proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.3   1.7e-05      0.15      76     139 ..      83     146 ..       9     153 .. 0.62
   2 ?   -1.7   0.0      0.24   2.2e+03      98      98 ..     237     237 ..     202     269 .. 0.48

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.7e-05
       NT-C2  76 eeKllelsvysvl..skskkkkelGkvelnlaeyvnedeepttsrfllkkskkvnsilslsiqlkl 139
                  +  l++s+y  +  +++ ++ +lG+v +n++ ++  +   ++ ++  k++ +v+s++++++  k+
  EFC36389.1  83 TP--LTFSIYHSYfaNYKDHEDFLGRVCVNISTLAHATNGVINLTLVDKQDVDVGSTITIRFEDKI 146
                 44..455555555559999999**************775555555555555888999988876555 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.24
       NT-C2  98 G 98 
                 G
  EFC36389.1 237 G 237
                 2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       457  (0.0254894); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1759.79
//
Query:       EFC36390.1  [L=454]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-07   28.7   1.3    2.9e-06   26.3   1.3    1.8  1  GNT-I     GNT-I family


Domain annotation for each model (and alignments):
>> GNT-I  GNT-I family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   1.3   1.6e-10   2.9e-06     177     312 ..     249     407 ..     245     428 .. 0.66

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 1.6e-10
       GNT-I 177 rhyklaldqvfvkkkfsrviileddleiapdffdyfeatasll...d....rdksllavsaW................ndnGkkqfvdasapealyrsd 252
                  hy + +  + +k +++ vi leddle +pdf+ y  + ++l+   +      k+++a++a+                n   k       + + l   d
  EFC36390.1 249 SHYIYGMYMLTQKLDYPYVITLEDDLEASPDFYRYHYSLYHLVygkEanyyDSKKIFAITAFtqgstvdchflvdklkN--DKSSKCGIHSVHQLVEED 345
                 6999************************************998443122223589*****9822222222222222112..33333333447789999* PP

       GNT-I 253 ffpGlGWllskktWaelePkWPka..fWddWlrlkerrkgrqfirPeisrtmsfGkkGsskG 312
                 +fpG G  ++++++ e   +W +    +d  + +    ++r  + P   r  +  ++G+  G
  EFC36390.1 346 YFPGWGSGITREIFMEYYSQWKVNgrIYDYGMSQLRVSEQRYTLVPCSPRVRTIANEGVNGG 407
                 *****************999987433566655555555555555555444444444444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (454 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.25s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 3097.42
//
Query:       EFC36391.1  [L=1010]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00063   19.5   6.9    0.00063   19.5   6.9    5.4  4  Collagen  Collagen triple helix repeat (20 copies)
  ------ inclusion threshold ------
       0.17   11.4   0.7       0.28   10.8   0.7    1.2  1  DUF4795   Domain of unknown function (DUF4795)


Domain annotation for each model (and alignments):
>> Collagen  Collagen triple helix repeat (20 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1  22.8   1.6e-06     0.014       1      58 [.      18      75 ..      16      80 .. 0.59
   2 ?  -22.4  68.3         2   1.8e+04       6      55 ..     120     169 ..     113     186 .. 0.45
   3 ?   -2.6  17.8      0.53   4.8e+03      32      55 ..     208     231 ..     202     240 .. 0.27
   4 !   19.5   6.9     7e-08   0.00063      12      46 ..     260     294 ..     257     296 .. 0.47

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.6e-06
                XXXXXXXXXXXXXXXXXX-----XXXXEEEE-TTSS-----------------BB--X CS
    Collagen  1 GppGepGepGppGppGkrGepGeaGekGekGpaGekGppGaaGkpGapGekGeaGapg 58
                G +G++G++G+ G +G+ Ge+G++  ++  G +Ge+G +G +G +G +G +Ge++++g
  EFC36391.1 18 GVKGRSGKRGSDGLHGAIGEEGKHALNATYGCEGESGGRGGNGYSGGHGGHGEDAESG 75
                4556666666666666666666666666666666666666666666666666665555 PP

  == domain 2  score: -22.4 bits;  conditional E-value: 2
                 XXXXXXXXXXXXX-----XXXXEEEE-TTSS-----------------BB CS
    Collagen   6 pGepGppGppGkrGepGeaGekGekGpaGekGppGaaGkpGapGekGeaG 55 
                 +G +G +G +G +G +G +G  G kG++G kG++G++Gk+Ga+G +G  G
  EFC36391.1 120 NGGDGGNGGNGGNGGKGGNGGIGGKGKKGTKGHNGEEGKSGADGGDGGYG 169
                 33333333333333333333333333333333333333333333333333 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.53
                 -TTSS-----------------BB CS
    Collagen  32 paGekGppGaaGkpGapGekGeaG 55 
                 + G  G+ G+aG+ G  Ge+G +G
  EFC36391.1 208 KYGLGGSAGSAGQGGLGGESGGEG 231
                 111111111111111111111111 PP

  == domain 4  score: 19.5 bits;  conditional E-value: 7e-08
                 XXXXXXX-----XXXXEEEE-TTSS---------- CS
    Collagen  12 pGppGkrGepGeaGekGekGpaGekGppGaaGkpG 46 
                 +G +G++G +G++G+ G +G +G++G++G +G++G
  EFC36391.1 260 KGIQGRSGLNGKTGSIGGNGTSGFNGHKGVDGSSG 294
                 34444444444444444444444444444444444 PP

>> DUF4795  Domain of unknown function (DUF4795)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.7   3.1e-05      0.28     105     147 ..     889     958 ..     861     962 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 3.1e-05
     DUF4795 105 e...........................eqeealkkaldtLqeelkekldrlelepLkeqleerlkelqk 147
                 +                           +q e  ++++dtL+  l +++ ++ l+ +k++++e++k+lqk
  EFC36391.1 889 DaifeslfvafchlhfqikwkvstfktiQQKELYDRFMDTLSLILYKQIGEQKLKIFKKKINEKVKNLQK 958
                 0444444444444445555666677777999999***********************************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1010 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.90u 0.32s 00:00:01.22 Elapsed: 00:00:00.54
# Mc/sec: 5679.88
//
Query:       EFC36392.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.5e-52  177.6   7.6    4.2e-52  177.4   7.6    1.1  1  Peptidase_C1    Papain family cysteine protease
  ------ inclusion threshold ------
       0.12   11.1   0.3        0.2   10.4   0.3    1.2  1  Peptidase_C1_2  Peptidase C1-like family
       0.74    9.7   9.4       0.24   11.2   4.6    2.3  2  CarbpepA_inh    Carboxypeptidase A inhibitor


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  177.4   7.6     7e-56   4.2e-52       1     213 [.      63     287 ..      63     294 .. 0.87

  Alignments for each domain:
  == domain 1  score: 177.4 bits;  conditional E-value: 7e-56
                   STSCEETTT.TTTG.SG---B-T...SSBTHHHHHHHHHHHHHHHHHHS..SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS- CS
  Peptidase_C1   1 lpesvDwre.kgga.vtpvkdqg...sCGsCWafsavgaledrlaiktk..kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdyp 90 
                   lp+s+Dwr+ +g++ ++ +++q+    CGsCWa+++++al dr++i++k     v lS q+++ C +     C GG  + +++y++++gi +e++++
    EFC36392.1  63 LPSSWDWRNvSGVNyLSVTRNQHiptYCGSCWAHGSTSALADRINIARKgqFPRVLLSVQHVIACAD--AGSCYGGEDTPVYQYAHDHGIPDESCNN 157
                   69*******866667999****99999*********************96556799*********97..679************************* PP

                   -SSSCS........SS-CGCGGGSE....EBEESEEEEEESSBHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEEEEE CS
  Peptidase_C1  91 Ykakeg........gkCkkkkkkek....vakikgygkvkenseealkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivGygv 175
                   Yka ++        g C+++ +++     v+k k+yg++    e++++++++++gP+s+ ida++ ++++Y++G++ +++ ++ ++nh + ++G+g+
    EFC36392.1 158 YKAVNQdcsafaecGFCNSTGCHSIsnykVWKAKEYGEIDG--EHQMMSEIYARGPISCGIDATS-ALEAYTGGIFAQYREDP-SINHIISVMGWGE 250
                   **999999999999555555433333444788888888887..79********************.5***********87776.9************ PP

                   ETTEEEEEEE-SBTTTSTBTTEEEEESSSSTGGGTTSS CS
  Peptidase_C1 176 engkkyWivkNsWgtdwgekGYiriargknnecgiese 213
                   engkk+Wiv+NsWg+ wge+G++ri+rg++  ++++ e
    EFC36392.1 251 ENGKKFWIVRNSWGQPWGEQGFFRIVRGNQ-DYNLAIE 287
                   ***************************987.5554443 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.3   3.3e-05       0.2     359     397 ..     239     275 ..     233     284 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 3.3e-05
                     --EEEEEEEEEE-TTSSEEEEEEE-SBTTTSTBTTEEEE CS
  Peptidase_C1_2 359 mtHamvltgvdvdddgkvtkwkvEnsWGedsGekGyfvm 397
                     ++H + + g  + + +  + w v nsWG+  Ge+G+f +
      EFC36392.1 239 INHIISVMGWGE-E-NGKKFWIVRNSWGQPWGEQGFFRI 275
                     566666777766.3.334569***************965 PP

>> CarbpepA_inh  Carboxypeptidase A inhibitor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.2      0.13   7.9e+02      22      31 ..      88      97 ..      87     101 .. 0.78
   2 ?   11.2   4.6     4e-05      0.24       8      31 ..     155     177 ..     151     187 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.13
                  SS--EE.EEE CS
  CarbpepA_inh 22 tlCqwCdklt 31
                  t C+ C+   
    EFC36392.1 88 TYCGSCWAHG 97
                  89****9765 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 4e-05
                   -S-B-SSSGGGSSSSS--EE.EEE CS
  CarbpepA_inh   8 CnkyCntnsDCsgitlCqwCdklt 31 
                   Cn+y  +n DCs    C++C ++t
    EFC36392.1 155 CNNYKAVNQDCSAFAECGFC-NST 177
                   ********************.665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       458  (0.0255452); expected 358.6 (0.02)
Passed bias filter:                      293  (0.0163422); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1870.65
//
Query:       EFC36393.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-06   26.9   0.1     0.0001   22.5   0.0    2.4  2  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0     0.014   2.6e+02      37      75 ..      98     131 ..      75     151 .. 0.71
   2 !   22.5   0.0   5.6e-09    0.0001       3      44 ..     267     310 ..     265     347 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.014
                 HHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSE CS
         BTB  37 FkalftskeieessvseielddvepeafealLefiYtge 75 
                 F + + ++     ++ + +ldd+e ++++++++ iY + 
  EFC36393.1  98 FVKTVLDN-----EQLMNKLDDFERQVIQRIIQHIYQEA 131
                 44444444.....23344679**************9864 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 5.6e-09
                 HHHHHT..TTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST CS
         BTB   3 elresg..elcDvtlvvgdgkefkahkavLaarSpyFkalftsk 44 
                 el+++g     D t+ +gdg  +++hk +La+ S +F+++++s 
  EFC36393.1 267 ELFNEGepLEYDFTIDFGDGIFIRTHKTILASNSLFFESMLSSS 310
                 56666645567*******************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       738  (0.0411624); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.24s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2523.76
//
Query:       EFC36394.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1352  (0.0754086); expected 358.6 (0.02)
Passed bias filter:                      598  (0.0333538); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1295.73
//
Query:       EFC36395.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0012   18.6   0.1     0.0013   18.5   0.1    1.2  1  SARAF     SOCE-associated regulatory factor of calcium homoeo


Domain annotation for each model (and alignments):
>> SARAF  SOCE-associated regulatory factor of calcium homoeostasis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.1     7e-08    0.0013     247     306 ..      19      82 ..       8     123 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 7e-08
       SARAF 247 rpGFWtGlatGaaaGYlagrrraqneeteeeekek.......sssWgsssegsssssssssssssas 306
                  p F  G+  G+  GY+ gr+++ n+++++ ++         ++ W + ++   + ++++ ++++++
  EFC36395.1  19 FPKFFFGMLVGGFVGYVWGRNNNCNQSHQN-HYGPfcgshdrHNCWDNRNS--YNPNHQQAFNNQTY 82 
                 4889*****************997665554.44446777776667765432..23333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       772  (0.0430587); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 816.29
//
Query:       EFC36396.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-10   39.7   0.3    7.9e-10   39.0   0.3    1.4  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.3   4.4e-14   7.9e-10       3      93 ..      41     149 ..      39     159 .. 0.88

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 4.4e-14
                 EEEEEEEEESSSSSSTTSSCEEEEEEEE...............ECEEEEEE-SCSSSSS.SEEEEEEEEEESC.....HTTSEEEEEEEEECSSSTEEE CS
          C2   3 levtvieAknLpnkdkkgssdpyvkvsl...............dgkqkakTrviknsln.PvWnekftfevae.....leeakLeveVfdndrlskddf 80 
                 ++vtv+ A++   k   +s +py+++ +               + ++ + T+vik s+  P+Wne+f+f ++e     + +  +++eV++++++  dd 
  EFC36396.1  41 IKVTVLGAEGFSSK---KSLNPYCSLRCnmfprntlvkywnedRISVSVHTKVIKESVTdPKWNETFEFFIDEeqvltEVNLNIKIEVLSKNTVLLDDS 136
                 6899*******888...689********************997778899*****999655*************99*999999***************** PP

                 EEEEEEEGHHHHT CS
          C2  81 iGkveiplstlls 93 
                  G+++i+++  + 
  EFC36396.1 137 FGNTSIDIDPEKY 149
                 *******998444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       516  (0.0287802); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.23s 00:00:00.63 Elapsed: 00:00:00.40
# Mc/sec: 1459.06
//
Query:       EFC36397.1  [L=266]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0073   16.7  28.7        1.1    9.8   1.4    6.7  6  LRR_4     Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
       0.12   13.0  12.4         31    5.7   0.0    6.7  7  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.3     0.016   1.4e+02       2      32 ..       3      41 ..       2      52 .. 0.67
   2 !    6.6   6.2    0.0013        11       1      33 [.      56      91 ..      32      99 .. 0.85
   3 !    4.0   0.1     0.008        71       3      30 ..     110     138 ..     108     155 .. 0.78
   4 !    4.5   0.2    0.0058        52      19      30 ..     159     169 ..     145     175 .. 0.75
   5 !    9.8   1.4   0.00012       1.1       2      39 ..     187     231 ..     186     237 .. 0.74
   6 ?   -1.9   0.0      0.59   5.3e+03      13      27 ..     235     249 ..     230     249 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.016
                S--EEE--S..S-.....--E-S-HHH.-TT--EEE-.- CS
       LRR_4  2 nLevLdLsn..Nq.....ltdipllek.lpnLkeLdLsg 32
                +L++L ++n  N      +  i+l+     nL++L + g
  EFC36397.1  3 QLTHLKINNfgNDdeekdIIGIDLFIEdKVNLEYLEMEG 41
                688888886444367777777888553378888888855 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0013
                SS--EEE--SS---E-S-HH.....H-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnNqltdiplle.....klpnLkeLdLsgN 33
                +nL++Ld +n  ++  ++ +     +lp+L++L    N
  EFC36397.1 56 KNLTFLDVNNSSMKNQDFANlivspNLPKLTTLKA--N 91
                69999999998999999944446767999999976..3 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.008
                 --EEE--SS---E-S-.HHH-TT--EEE- CS
       LRR_4   3 LevLdLsnNqltdipl.leklpnLkeLdL 30 
                  ++Ld++ + l  +p+ l  +p+Lk+L +
  EFC36397.1 110 VTYLDIRYCELVLFPSlLDHCPKLKKLKV 138
                 68899999988877774556999988864 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.0058
                 HHH-TT--EEE- CS
       LRR_4  19 leklpnLkeLdL 30 
                 ++ l nL++Ld+
  EFC36397.1 159 PS-LSNLEYLDI 169
                 44.9*******9 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.00012
                 S--EEE--.S...S---E-S-...HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLs.n...Nqltdipl...leklpnLkeLdLsgNnlitdl 39 
                 nL++L L  +   Nq  di+l   +  l nLk+LdL++  ++  l
  EFC36397.1 187 NLQELRLElHessNQTLDISLvskCTTLVNLKTLDLWRTEYLAEL 231
                 777777777556698777888545557*********998666665 PP

  == domain 6  score: -1.9 bits;  conditional E-value: 0.59
                 --E-S-HHH-TT--E CS
       LRR_4  13 ltdiplleklpnLke 27 
                 ++  p ++k +nLk+
  EFC36397.1 235 IKRNPTFSKVKNLKV 249
                 677788889999985 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.74   6.7e+03       2       9 ..       4      11 ..       3      21 .. 0.74
   2 ?   -0.7   0.0      0.43   3.9e+03       1       9 [.      33      41 ..      33      53 .. 0.82
   3 ?    1.4   0.2     0.084   7.5e+02       1      11 [.      57      67 ..      57      93 .. 0.79
   4 ?    5.7   0.0    0.0034        31       3      23 .]     111     130 ..     109     138 .. 0.81
   5 ?    4.8   0.0    0.0067        60       1      11 [.     163     173 ..     163     183 .. 0.86
   6 ?    0.1   0.2      0.22     2e+03       1      10 [.     187     200 ..     187     211 .. 0.63
   7 ?    2.1   0.0     0.049   4.4e+02       1       8 [.     216     223 ..     216     243 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.74
       LRR_1  2 LrhLdLsn 9 
                L+hL ++n
  EFC36397.1  4 LTHLKINN 11
                88888854 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.43
       LRR_1  1 nLrhLdLsn 9 
                nL++L +++
  EFC36397.1 33 NLEYLEMEG 41
                89***9976 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.084
       LRR_1  1 nLrhLdLsnnp 11
                nL+ Ld++n +
  EFC36397.1 57 NLTFLDVNNSS 67
                8999**98877 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.0034
       LRR_1   3 rhLdLsnnpllglppnsfqnL 23 
                 ++Ld++++ l  l p+ + ++
  EFC36397.1 111 TYLDIRYCEL-VLFPSLLDHC 130
                 79*******9.6777666655 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.0067
       LRR_1   1 nLrhLdLsnnp 11 
                 nL++Ld++ + 
  EFC36397.1 163 NLEYLDITCCG 173
                 8******9996 PP

  == domain 6  score: 0.1 bits;  conditional E-value: 0.22
       LRR_1   1 nLrhLdL....snn 10 
                 nL++L L    s+n
  EFC36397.1 187 NLQELRLelheSSN 200
                 79999885565333 PP

  == domain 7  score: 2.1 bits;  conditional E-value: 0.049
       LRR_1   1 nLrhLdLs 8  
                 nL++LdL 
  EFC36397.1 216 NLKTLDLW 223
                 8*****94 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       587  (0.0327403); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.27s 00:00:00.67 Elapsed: 00:00:00.40
# Mc/sec: 1982.95
//
Query:       EFC36398.1  [L=185]
Description: Hypothetical protein NAEGRDRAFT_75908 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00011   22.0   0.4    0.00011   22.0   0.4    2.3  3  F-box       F-box domain
  ------ inclusion threshold ------
      0.015   15.2   1.8      0.019   14.8   0.5    1.8  2  F-box-like  F-box-like
      0.015   15.1   0.3      0.056   13.3   0.0    2.1  2  F-box_4     F-box
       0.02   15.0   0.2        0.1   12.8   0.0    2.1  2  ACP53EA     Drosophila ACP53EA protein
       0.03   13.8   0.2      0.046   13.2   0.2    1.2  1  Vps8        Golgi CORVET complex core vacuolar protein 8


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.4     3e-08   0.00011       4      40 ..      67     104 ..      65     109 .. 0.94
   2 ?   -2.7   0.0       1.7     6e+03      20      28 ..     137     145 ..     137     146 .. 0.82
   3 ?   -2.0   0.1         1   3.7e+03      18      28 ..     149     159 ..     145     162 .. 0.62

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 3e-08
                 HHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTH CS
       F-box   4 srLPsevlrhILerLplsd.llalrrVSkgwrilidsd 40 
                 +rL s+vl hI ++L+ ++    + +VSk wr+ +d++
  EFC36398.1  67 DRLNSDVLSHIYQFLDNTTlQECCCLVSKLWRQSVDGL 104
                 69**********************************97 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.7
                 HHHHHHHCT CS
       F-box  20 lsdllalrr 28 
                 +++l ++r+
  EFC36398.1 137 FKSLANCRS 145
                 789999996 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1
                 S-HHHHHHHCT CS
       F-box  18 Lplsdllalrr 28 
                 +   dll+l+ 
  EFC36398.1 149 MKSLDLLSLSN 159
                 55566666664 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.5   5.3e-06     0.019       7      35 ..      72     101 ..      68     104 .. 0.89
   2 ?   -4.1   0.0       4.5   1.6e+04      20      27 ..     153     160 ..     149     160 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.3e-06
  F-box-like   7 EiLlqIFsyLppsdLlr.lalVCrrWrrva 35 
                 ++L++I ++L+ ++L   ++lV++ Wr+ +
  EFC36398.1  72 DVLSHIYQFLDNTTLQEcCCLVSKLWRQSV 101
                 79********9999999569*******976 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 4.5
  F-box-like  20 dLlrlalV 27 
                 dLl+l+ V
  EFC36398.1 153 DLLSLSNV 160
                 78888766 PP

>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.6e-05     0.056       6      37 ..      67      99 ..      49     110 .. 0.87
   2 ?   -1.2   0.1      0.49   1.8e+03      23      98 ..     155     167 ..     140     174 .. 0.59

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.6e-05
     F-box_4  6 ssLPlevlqhiaslLDsfsLsqL.slvskllre 37
                ++L  +vl hi ++LD+++L +   lvskl r+
  EFC36398.1 67 DRLNSDVLSHIYQFLDNTTLQECcCLVSKLWRQ 99
                67899***************9764789998886 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.49
     F-box_4  23 fsLsqLslvskllrevcssllqergiVllkWekkkyskgksswkikkkvwefstlfskvksWkfedvsslseHLkk 98 
                 +sLs+++                                                                eHL k
  EFC36398.1 155 LSLSNVA---------------------------------------------------------------VEHLTK 167
                 3333332...............................................................244444 PP

>> ACP53EA  Drosophila ACP53EA protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   2.9e-05       0.1      17      70 ..      42      96 ..      32     104 .. 0.85
   2 ?   -0.6   0.0      0.43   1.6e+03      25      44 ..     137     156 ..     122     174 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.9e-05
     ACP53EA 17 liekaipavkkLakCidfepkk.kkelsilrvlkliyqflkklvldkpkCllktl 70
                +i++ i  +++++k  df+ kk + ++   +vl  iyqfl    l++  Cl++ l
  EFC36398.1 42 MIDEFIGNIHEFLKQLDFNRKKaSSDRLNSDVLSHIYQFLDNTTLQECCCLVSKL 96
                7899999***********6665155666789********************9877 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.43
     ACP53EA  25 vkkLakCidfepkkkkelsi 44 
                  k+La+C   + +k+ +l +
  EFC36398.1 137 FKSLANCRSLDKMKSLDLLS 156
                 56677776665555444333 PP

>> Vps8  Golgi CORVET complex core vacuolar protein 8
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   1.3e-05     0.046      55     120 ..      20      83 ..      12      88 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.3e-05
        Vps8  55 qvlklckehrLydaliYvwnkal.dDYvtPlvellklirsaeeeeeekeeeeeeeeeaykvfeYlsy 120
                 q ++l+++ +L d   + +n+++ d+++  + e+lk++     +++++++++ +++   +++++l +
  EFC36398.1  20 QLISLVNKVKLADSCYFMYNNGMiDEFIGNIHEFLKQLDF---NRKKASSDRLNSDVLSHIYQFLDN 83 
                 889*****************987356*************9...445555555555555788888865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       627  (0.0349713); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1158.60
//
Query:       EFC36399.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       696  (0.0388198); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2002.48
//
Query:       EFC36400.1  [L=1362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.1e-43  146.3 163.8    6.7e-05   23.2   6.8   10.5 10  EGF_2            EGF-like domain
    5.9e-13   48.9 118.1      0.064   13.6   3.8   11.7 11  EGF              EGF-like domain
    4.5e-12   45.3   7.2    4.4e-06   26.5   0.0    7.8  9  NHL              NHL repeat
      0.002   17.8   2.8         19    4.8   0.0    4.4  4  SGL              SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.013   15.4   2.1      0.013   15.4   2.1    1.9  2  TMEM154          TMEM154 protein family
      0.029   14.5   0.2      0.062   13.4   0.2    1.4  1  ECF_trnsprt      ECF transporter, substrate-specific componen
      0.053   13.5   1.8       0.12   12.3   0.2    2.3  2  Gram_pos_anchor  LPXTG cell wall anchor motif
      0.084   13.1   2.1       0.64   10.2   0.1    2.8  2  Methylase_S      Type I restriction modification DNA specific


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   7.1   2.2e-07    0.0005       5      32 .]     696     722 ..     692     722 .. 0.89
   2 !   20.7   9.2   1.7e-07   0.00039       5      32 .]     737     763 ..     733     763 .. 0.91
   3 !   12.0  11.8     9e-05       0.2       5      32 .]     783     809 ..     775     809 .. 0.89
   4 !   21.0   9.3   1.4e-07   0.00031       6      32 .]     829     854 ..     824     854 .. 0.91
   5 !   21.7  10.6   8.3e-08   0.00019       5      32 .]     873     899 ..     870     899 .. 0.91
   6 !   21.7   9.8   8.4e-08   0.00019       6      32 .]     921     946 ..     917     946 .. 0.90
   7 !   22.1  10.4   6.7e-08   0.00015       5      32 .]     959     985 ..     951     985 .. 0.90
   8 !   23.2   6.8     3e-08   6.7e-05       5      32 .]     998    1024 ..     995    1024 .. 0.89
   9 !   17.9  10.0   1.3e-06    0.0029       5      32 .]    1039    1065 ..    1036    1065 .. 0.90
  10 !   22.6   6.8   4.6e-08    0.0001       6      32 .]    1079    1104 ..    1075    1104 .. 0.92

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 2.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C+ +  qC+C+ g+ G  C
  EFC36400.1 696 SLVCSGNGQCNVTD-QCSCNEGFIGSMC 722
                 789*******9888.**********999 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 1.7e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hG C++++ +C+C +g++G++C
  EFC36400.1 737 SLVCSSHGDCISKN-NCSCYNGFYGDNC 763
                 678********999.8************ PP

  == domain 3  score: 12.0 bits;  conditional E-value: 9e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G C+++  +C C+ gy+G +C
  EFC36400.1 783 SSVCSGFGNCIATD-NCTCSVGYSGSNC 809
                 689*******9777.8************ PP

  == domain 4  score: 21.0 bits;  conditional E-value: 1.4e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghG+Cv++  +C C +gy+G +C
  EFC36400.1 829 SVCSGHGQCVSKD-NCTCATGYYGSSC 854
                 68********999.8************ PP

  == domain 5  score: 21.7 bits;  conditional E-value: 8.3e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG+C++++ qC C+ gy+G +C
  EFC36400.1 873 STVCSGHGSCNSSN-QCLCSEGYTGSSC 899
                 578********888.************* PP

  == domain 6  score: 21.7 bits;  conditional E-value: 8.4e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ghG C +++ +C+C++gy+G +C
  EFC36400.1 921 VVCSGHGNCLSSN-NCSCETGYSGSDC 946
                 67*******9888.8************ PP

  == domain 7  score: 22.1 bits;  conditional E-value: 6.7e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ghG+C +++  C+C++gy+G++C
  EFC36400.1 959 SAVCSGHGSCSAPN-TCSCSNGYSGNDC 985
                 678********999.9************ PP

  == domain 8  score: 23.2 bits;  conditional E-value: 3e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ghG+C++++ qC C+ g+ G+ C
  EFC36400.1  998 SLVCSGHGVCNSTN-QCLCSEGFIGNEC 1024
                  578********666.************* PP

  == domain 9  score: 17.9 bits;  conditional E-value: 1.3e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C++hG C ++  +C+C++gy G++C
  EFC36400.1 1039 SNVCSQHGECMSKD-NCQCQDGYVGANC 1065
                  689*******8888.7************ PP

  == domain 10  score: 22.6 bits;  conditional E-value: 4.6e-08
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g+G+C ++   C C+ g++Gk+C
  EFC36400.1 1079 NVCSGNGKCPAPD-SCLCNEGWFGKNC 1104
                  68*******9999.7************ PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   2.9   7.4e-05      0.16       5      30 ..     695     719 ..     692     720 .. 0.83
   2 ?    5.0   4.4     0.014        30       6      32 .]     740     762 ..     735     762 .. 0.90
   3 !   11.5   3.7   0.00013      0.29       6      32 .]     786     808 ..     780     808 .. 0.89
   4 !   12.7   4.2   5.3e-05      0.12       6      31 ..     831     852 ..     825     853 .. 0.89
   5 !   12.6   5.1   5.6e-05      0.13       5      31 ..     874     897 ..     871     898 .. 0.82
   6 !    7.4   4.4    0.0024       5.5       6      31 ..     923     944 ..     918     945 .. 0.86
   7 !    8.1   6.2    0.0014       3.2       5      31 ..     959     983 ..     951     984 .. 0.80
   8 !   11.6   3.0   0.00012      0.26       6      31 ..    1001    1022 ..     996    1023 .. 0.86
   9 !   12.3   4.3   7.4e-05      0.17       3      32 .]    1039    1064 ..    1037    1064 .. 0.87
  10 !   13.6   3.8   2.8e-05     0.064       4      32 .]    1078    1103 ..    1076    1103 .. 0.86
  11 ?    1.2   0.2      0.21   4.8e+02       5      22 ..    1103    1122 ..    1102    1123 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 7.4e-05
                 T...STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytG 30 
                 +   Cs++G C    + + +C C eG+ G
  EFC36400.1 695 NslvCSGNGQC----NVTDQCSCNEGFIG 719
                 5566*******....66679*******99 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.014
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs +G C++      +C C +G+ G++
  EFC36400.1 740 CSSHGDCISKN----NCSCYNGFYGDN 762
                 *******9999....**********86 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 0.00013
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs+ G C+ t     +C+C++Gy+G++
  EFC36400.1 786 CSGFGNCIATD----NCTCSVGYSGSN 808
                 *******9999....**********86 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 5.3e-05
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G Cv+      +C+C++Gy G+
  EFC36400.1 831 CSGHGQCVSKD----NCTCATGYYGS 852
                 ***********....********996 PP

  == domain 5  score: 12.6 bits;  conditional E-value: 5.6e-05
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + Cs++G C    + + +C C+eGytG+
  EFC36400.1 874 TvCSGHGSC----NSSNQCLCSEGYTGS 897
                 35*******....66669*********6 PP

  == domain 6  score: 7.4 bits;  conditional E-value: 0.0024
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C+++     +C C +Gy+G+
  EFC36400.1 923 CSGHGNCLSSN----NCSCETGYSGS 944
                 *******7777....**********7 PP

  == domain 7  score: 8.1 bits;  conditional E-value: 0.0014
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                    Cs++G C  +     tC C++Gy+G+
  EFC36400.1 959 SavCSGHGSCSAPN----TCSCSNGYSGN 983
                 255*******5555....**********7 PP

  == domain 8  score: 11.6 bits;  conditional E-value: 0.00012
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs++G C    + + +C C+eG+ G+
  EFC36400.1 1001 CSGHGVC----NSTNQCLCSEGFIGN 1022
                  *******....6666*********97 PP

  == domain 9  score: 12.3 bits;  conditional E-value: 7.4e-05
                  STTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGkr 32  
                  +n Cs +G+C++      +C+C+ Gy G++
  EFC36400.1 1039 SNVCSQHGECMSKD----NCQCQDGYVGAN 1064
                  366*******9999....********9975 PP

  == domain 10  score: 13.6 bits;  conditional E-value: 2.8e-05
                  TT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    4 np.CsngGtCvdtgrggytCiCpeGytGkr 32  
                   + Cs++G+C   +    +C C eG++Gk+
  EFC36400.1 1078 LNvCSGNGKC---P-APDSCLCNEGWFGKN 1103
                  455*******...7.788**********97 PP

  == domain 11  score: 1.2 bits;  conditional E-value: 0.21
                  TSTTT-EEEEET...TTEEEE CS
         EGF    5 pCsngGtCvdtg...rggytC 22  
                  +Csn+  Cv++    +g  tC
  EFC36400.1 1103 NCSNRV-CVSVVdviNGNVTC 1122
                  6****8.*8887777888888 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.3   0.00039      0.87       2      27 ..     122     148 ..     122     149 .. 0.93
   2 ?   -2.9   0.0       3.8   8.6e+03      11      19 ..     241     249 ..     240     253 .. 0.84
   3 ?   -0.1   0.0       0.5   1.1e+03      14      25 ..     302     313 ..     289     314 .. 0.74
   4 ?    1.7   0.0      0.14   3.1e+02       2      26 ..     346     371 ..     345     371 .. 0.76
   5 ?   -3.1   0.0       4.5     1e+04      12      20 ..     407     415 ..     407     417 .. 0.84
   6 !   26.5   0.0     2e-09   4.4e-06       1      27 [.     448     474 ..     448     475 .. 0.96
   7 ?   -0.8   0.0      0.87   1.9e+03       1      18 [.     504     521 ..     504     521 .. 0.89
   8 ?    1.4   0.0      0.18     4e+02       5      27 ..     548     571 ..     547     572 .. 0.89
   9 ?   -2.4   0.0       2.7     6e+03       4      18 ..     605     619 ..     603     622 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00039
                 SSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvqv 27 
                 n P++v vd snGd++ +D  nh++++
  EFC36400.1 122 NGPTSVIVDsSNGDVFFTDDWNHCIRK 148
                 67999********************97 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.8
                 TTTEEEEEE CS
         NHL  11 snGdiyVaD 19 
                 s+Gd+y +D
  EFC36400.1 241 STGDVYLSD 249
                 78****999 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.5
                 EEEEEECCCTEE CS
         NHL  14 diyVaDsenhrv 25 
                  +y+ +s+nh +
  EFC36400.1 302 TLYIVESGNHLL 313
                 69********87 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.14
                 SSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvq 26 
                 n+P+++  d  n+ ++++D+ n r++
  EFC36400.1 346 NNPSDLFHDeANNMFLISDTDNGRIR 371
                 556666666678889*********95 PP

  == domain 5  score: -3.1 bits;  conditional E-value: 4.5
                 TTEEEEEEC CS
         NHL  12 nGdiyVaDs 20 
                 +G +y++D+
  EFC36400.1 407 DGSLYISDY 415
                 799*****7 PP

  == domain 6  score: 26.5 bits;  conditional E-value: 2e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 fn+P+ +a +s +++++aDs+nhr+++
  EFC36400.1 448 FNSPNKLAFNSRNELFIADSNNHRIRK 474
                 99***********************86 PP

  == domain 7  score: -0.8 bits;  conditional E-value: 0.87
                 BSSEEEEEEETTTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVa 18 
                 +++P+++ v++n+d+++a
  EFC36400.1 504 LANPTSLFVLPNDDLLIA 521
                 57899999*******997 PP

  == domain 8  score: 1.4 bits;  conditional E-value: 0.18
                 EEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   5 hGvavd.snGdiyVaDsenhrvqv 27 
                 ++++v+ +n diy ++  +h+v++
  EFC36400.1 548 SDLTVNlNNLDIYFSEKSTHTVKK 571
                 689**********99999999986 PP

  == domain 9  score: -2.4 bits;  conditional E-value: 2.7
                 EEEEEEETTTEEEEE CS
         NHL   4 PhGvavdsnGdiyVa 18 
                 P+++ +++nG+++++
  EFC36400.1 605 PNSILLTQNGELIIS 619
                 78888899****997 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.034        76       4      61 ..      67     143 ..      56     175 .. 0.73
   2 !    4.8   0.0    0.0083        19     127     159 ..     282     314 ..     242     327 .. 0.83
   3 ?    2.6   0.2     0.037        83      86     161 ..     397     475 ..     339     542 .. 0.78
   4 ?    3.7   0.0     0.018        40      38      87 ..     601     649 ..     560     656 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.034
         SGL   4 GpvwdeeegaLlwvDilgqrihrldpatgketv...................ldtpesvGaiaprkdgrlvvasksg 61 
                 G  w++ +++++++D  ++ + +++++++                       ++++++ ++i++  +g + ++   +
  EFC36400.1  67 GLFWVPSTQEVFFTDLERNAVSKITASGQLVDLiggselrrgysgdgslavnAKINGPTSVIVDSSNGDVFFTDDWN 143
                 78899999999999999999999998888888877777777777777766666666677777765556666665544 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0083
         SGL 127 ervlddltipNGlawspdgktlYlaDsltrkiw 159
                 +   +++++p G+ ++++++tlY+++s ++ + 
  EFC36400.1 282 KISDQKMSVPTGIFLNAAETTLYIVESGNHLLR 314
                 4556789********************887665 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.037
         SGL  86 lrfNDgvvdpdGrlwfGtmgdeeakgeev.....galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiway 161
                  ++N   +  dG+l++ + +  ++++ ++     ++l+ ++++  + r  + ++ pN la+++ ++ ++ aDs +++i ++
  EFC36400.1 397 SSLNSFTFGMDGSLYISDYSTIRSGNSNFdiyagTGLVGYSGN-YTLRNSTLFNSPNKLAFNSRNELFI-ADSNNHRIRKV 475
                 5678888888899999988888888887788876666666666.4455667789999999999888776.99999998764 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.018
         SGL  38 dtpesvGaiaprkdgrlvvasksglalldlasgeletladeeedekpllr 87 
                  ++++++++   ++g+l++ ++s+++++ l++  ++t++ + ++ +++++
  EFC36400.1 601 TIDSPNSILLT-QNGELIISEQSRIRRVTLNDNLISTITLYDNSTQTNTS 649
                 45567777777.99**************99**999999999766655555 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       2.4   5.4e+03      70      90 ..       8      27 ..       6      29 .. 0.76
   2 ?   15.4   2.1   5.6e-06     0.013      29      96 ..    1286    1357 ..    1266    1361 .. 0.59

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.4
     TMEM154 70 illllvviiliqkkkrkrsKd 90
                + ++ v+++li  ++++r+ +
  EFC36400.1  8 LAIIWVMCLLI-SHQQTRAQQ 27
                45677888888.999999877 PP

  == domain 2  score: 15.4 bits;  conditional E-value: 5.6e-06
     TMEM154   29 steseslkqeeakeslssaelsnesdqlelvlmiiiPlvllillllvviiliqk....kkrkrsKddeksea 96  
                  s+++  +k++++  ++ +++ +++s++  +++ +++  ++  l+++vv i+i +      +kr+K++++s +
  EFC36400.1 1286 SVIDINIKKQNSPSTTIQPKQDQTSNDSTVIIAVLVSVIASSLIFFVVGIVIGVsvalLYKKRKKEKDYSAS 1357
                  222444444444455555555666666666999999999999999999999854111134555555555544 PP

>> ECF_trnsprt  ECF transporter, substrate-specific component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.2   2.8e-05     0.062      71      98 ..    1322    1352 ..    1312    1361 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.8e-05
                   HHH...HHHHHHHHCHHHHHHHHHHCCCHTT CS
  ECF_trnsprt   71 sfv...piaflsriligliagllykkgkkkn 98  
                   s++   +i+f+++i+ig+ ++llykk+kk +
   EFC36400.1 1322 SVIassLIFFVVGIVIGVSVALLYKKRKKEK 1352
                   2224559*****************7666654 PP

>> Gram_pos_anchor  LPXTG cell wall anchor motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.69   1.5e+03      15      28 ..     317     330 ..     316     334 .. 0.84
   2 ?   12.3   0.2   5.3e-05      0.12      16      42 ..    1326    1352 ..    1314    1353 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.69
                      XXXXXXXXXXXXXX CS
  Gram_pos_anchor  15 ngnifltaaGllal 28 
                      +g +++t+aG +++
       EFC36400.1 317 TGDKIYTIAGTAMT 330
                      67899*****9885 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 5.3e-05
                       XXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Gram_pos_anchor   16 gnifltaaGllallggllLlvkrRKke 42  
                       +++++ ++G+ + ++ +lL++kr+K++
       EFC36400.1 1326 SSLIFFVVGIVIGVSVALLYKKRKKEK 1352
                       6788999**999999999999999997 PP

>> Methylase_S  Type I restriction modification DNA specificity domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.1   0.00028      0.64      52     114 ..     508     571 ..     476     588 .. 0.77
   2 ?    1.2   0.1      0.17   3.7e+02      42      70 ..     641     673 ..     608     714 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00028
                  TT---B-TT-EEEE-SSSTT-EEEESS-.BEE-TTEEEEEEST.TT--HHHHHHHHHHCHHHHHH CS
  Methylase_S  52 kkkyilpkgdilissratiGkvayrdkk.yylnqsvivlipkn.kkkineflylylllklkklks 114
                  ++ ++lp++d+li+s ++i+kv+ ++   ++l+ s++v+i+ +   ++n+ ++++  + ++ +k+
   EFC36400.1 508 TSLFVLPNDDLLIASTGKISKVFANNGTiVTLYRSMGVIIS-DlTVNLNNLDIYFSEKSTHTVKK 571
                  67899**********************83588888888887.43444456666665555554444 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.17
                  T...EE-HHHHCCTT---B-.TT-EEEE-SSST CS
  Methylase_S  42 n...kvvkdglgykkkyilp.kgdilissrati 70 
                  +   +++ ++++++k  +l+ +gdil++ + ti
   EFC36400.1 641 DnstQTNTSFINQAKSLYLNaNGDILYAEGCTI 673
                  134456679999999999999******998443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1178  (0.0657036); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.95u 0.30s 00:00:01.25 Elapsed: 00:00:00.49
# Mc/sec: 8428.03
//
Query:       EFC36401.1  [L=316]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.059   13.0   1.1       0.12   12.0   1.0    1.6  1  PepSY_TM  PepSY-associated TM region
       0.12   12.5   7.5       0.12   12.6   4.6    2.2  2  GWT1      GWT1
        1.3    9.4   4.5         23    5.5   2.1    2.8  2  COX7a     Cytochrome c oxidase subunit VII


Domain annotation for each model (and alignments):
>> PepSY_TM  PepSY-associated TM region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   1.0   2.1e-05      0.12     130     216 ..     133     237 ..     101     304 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.1e-05
                 xxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxx..............xxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxx RF
    PepSY_TM 130 laallllvllvsGlilwwprrkkk.....rfftfrpkkgrrfwl..............dlHnvlGvwllpfllllalTGlvw..slaavlgaavkalvs 207
                   all l l++sGlil +            f  f   + r+f+                lH+ +G+ +  f+++la+T l +  ++ +++ a+ +++++
  EFC36401.1 133 CIALLILHLILSGLILLFDFLEIIfpngyDFRMFGISS-RKFNSlgsgaasssssidsPLHASAGTRVGYFFAILAVTVLGIfcFITTMYSAPDQSTTA 230
                 57999999*********887776688777444444444.667779999********999*******************665522444444444444333 PP

                 xxxxxxxxx RF
    PepSY_TM 208 egaaaaaaa 216
                 +  a++a++
  EFC36401.1 231 A--ATSADN 237
                 2..222222 PP

>> GWT1  GWT1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.4     0.024   1.4e+02      84     107 ..     198     221 ..      86     243 .. 0.58
   2 ?   12.6   4.6   1.9e-05      0.12      15      97 ..     204     303 ..     196     316 .] 0.68

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.024
        GWT1  84 NlpYvlwvvalnltllllflliel 107
                  ++Y++ ++a+++  +++f+ +  
  EFC36401.1 198 RVGYFFAILAVTVLGIFCFITTMY 221
                 456777777766666655554333 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 1.9e-05
        GWT1  15 iyllgvslgkyvlkrekeae.............eee.....kkkkkkkkesketlkllikllllsilllllllllelyvefvSRrlaNlpYvlwvvaln 95 
                   l+ + lg + + ++ +++             + +     ++k+  +k++  +l+l++  l++ +l++l++ l+ l++   S +l  ++Yvlw ++ +
  EFC36401.1 204 AILAVTVLGIFCFITTMYSApdqsttaaatsadN-NssrsgRMKSFFTKHRDWILRLFTCYLICITLCILVTALFFLNIGLLSFVLLAVQYVLWSASHK 301
                 4444444444444333333333444455555441.055666777777889999999999999999999999999999*****************99987 PP

        GWT1  96 lt 97 
                 + 
  EFC36401.1 302 TR 303
                 65 PP

>> COX7a  Cytochrome c oxidase subunit VII
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.022   1.3e+02       6      43 ..     109     144 ..     108     148 .. 0.88
   2 ?    5.5   2.1    0.0038        23      29      50 ..     199     220 ..     191     222 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.022
       COX7a   6 lQrlfQssdkkplwlrgprsklylypyyalfavgllgs 43 
                 +Q lfQ+ +   l+  + + k+ ++  +al++  l++s
  EFC36401.1 109 NQSLFQN-PY-LLYRVTGQNKISVWSCIALLILHLILS 144
                 6899***.77.9******************99988877 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0038
       COX7a  29 lypyyalfavgllgslygmyrm 50 
                 ++ ++a++av++lg+++ ++ m
  EFC36401.1 199 VGYFFAILAVTVLGIFCFITTM 220
                 3446**************9988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1001  (0.0558313); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2121.64
//
Query:       EFC36402.1  [L=1330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-38  132.7   1.4    9.5e-38  130.1   1.4    2.1  1  Peptidase_S8     Subtilase family
    1.7e-05   25.1   0.2    6.3e-05   23.2   0.2    2.0  1  fn3              Fibronectin type III domain
  ------ inclusion threshold ------
       0.12   12.4   0.1         11    6.1   0.1    2.3  2  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe


Domain annotation for each model (and alignments):
>> Peptidase_S8  Subtilase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  130.1   1.4   1.6e-41   9.5e-38       1     288 [.     393     802 ..     393     823 .. 0.77

  Alignments for each domain:
  == domain 1  score: 130.1 bits;  conditional E-value: 1.6e-41
                   -TT-EEEEECS-B-TT-TTTGGGEEE..EEE.E---TTSG.GGEETT-SS-TT-SC-SSS....HHHHHHHHHH-B........SSSSSB-SSTTSE CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxx RF
  Peptidase_S8   1 gkgvlvavlDtGvdpshpdlsvttdgerklv.dvideegagfngadsettstnwarddngnsieHGthvAGiaaan......apeegekngvapgak 90 
                   g + +va++DtG+d +++++s   d+ r+++ d+ +   +++++ +++  ++++++d+      HGthv+G +a++          ++ +gvapgak
    EFC36402.1 393 GTNQVVAIADTGLDFDNCFFS---DSSRPMTfDTMNSLRRKVVYYKTTYADNYDGVDG------HGTHVCGSVAGSienadlNTGLNQYHGVAPGAK 480
                   6789*****************...4455554044444444566666666666666666......*************9998888899********** PP

                   EE.............................EEE-SSTTSB-HH..HHHHHHHHHHHHCT-S...........EEEE-EESCETTCHHCHHHHHH.. CS
                   xx.............................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........xxxxxxxxxxxxxxxxxxxxxx.. RF
  Peptidase_S8  91 il.............................svkvldtsggsmetgteliraieeaaedkvd...........vinmslgestslpktgrsieal.. 145
                   i                              +++++++s+g     + l++ ++ +   k +           v             t ++      
    EFC36402.1 481 IFftdlektsqpgslmipdpisnlfsvpysmGARIFSNSFGCGP--ESLVDCAYNCQSCKLRvsiqgydegqvV-------------TNED---Ckl 559
                   **996666666666666666666666666666666666665554..4444444444443333222222222221.............1222...123 PP

                   ...................HHHHHH.CC.T-EEEEE--SS-T-HHEEE-TTCEECTTTSTTCEEEEEES............................ CS
                   ...................xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............................ RF
  Peptidase_S8 146 ...................ainravnkk.gvlvviSaGNngktgsslqagspvgtpstsknvitvgayt............................ 194
                                        +++ +++ + ++ +S GN+g     ++   + g+p+ skn +tvga +                            
    EFC36402.1 560 ifgvptcceacnvyntqcqDTDTFLWNNkEAIILFSQGNSG----AISEFGNTGYPAVSKNTLTVGAHQtsnagyvdgvnyddflhkmqqaglpwts 652
                   45666666666666777667778888777************....6788999999****************************************** PP

                   ...................................TTSSB-TT--B-TT.......-EEEE-S-CCCCCCCCCHHHTTTHH...........EEEE- CS
                   ...................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........xxxxx RF
  Peptidase_S8 195 ...................................tegkiapfSsrGpssdgklkpdivapGgnivstwsrqsnnsaglss...........yqsms 245
                                                      +e+++a+fSsrGp++ g++kpd+v  G+ ++st+s  +++s++  +           + + s
    EFC36402.1 653 taeccaysgynkdevrayccpsaiktgyssqpnnyNENNLASFSSRGPAMGGRIKPDVVGVGQTVISTHSDGTTTSKNC-GtqspqlnnnaaLYLLS 748
                   ****************************************************************888888777444332.2467********88*** PP

                   SHHHCHHHHHHHHHHHHHHHTT...--HHH.....HHHHHHCCS-EE......... CS
                   xxxxxxxxxxxxxxxxxxxxxx...xxxxx.....xxxxxxxxxxxx.....xxxx RF
  Peptidase_S8 246 GTSmAsPnaagaaAlllsalpk...ltpet.....vraallntAqdl.....gkad 288
                   GTSmA+P  aga+Al+++ ++k   ++  +     ++aa++n+A++l     + +d
    EFC36402.1 749 GTSMATPITAGAVALVRQFFQKtlsIS--NpsgtlLKAAIINSASPLtgtvaYSND 802
                   ******************998886633..334778***********9877773333 PP

>> fn3  Fibronectin type III domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.2   1.1e-08   6.3e-05       2      74 ..    1016    1076 ..    1015    1084 .. 0.86

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 1.1e-08
                  CECEEEEEEESSSEEEEEEE-CSSSSSTEEEEEEEEEETTSTSTEEEEEECSTSSEEEEESSSTTEEEEEEEE CS
         fn3    2 aPsnlsvsevtstsltvsWeppkdgggpitgYeveyrekgseeewneftvprtttsvtltgLkpgteYevrVq 74  
                  +Psn++++ vt+++++++We+p   ++ +  ++v y ++  +        +++t +  +tgLk+g  Y++ + 
  EFC36402.1 1016 PPSNIQITRVTPDTIQLHWEKP---NQMDYDFHVMYDSTVLN--------TKDT-TISITGLKAGVSYNLHIF 1076
                  8*********************...*********99777444........3555.69***********99886 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.011        63      20      55 ..      14      49 ..       7      58 .. 0.72
   2 ?    6.1   0.1    0.0018        11      30      62 ..    1264    1296 ..    1256    1312 .. 0.62

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.011
  Phage_holin_3_6 20 eLakaElkeeakragsgagllgaagvlallalllll 55
                     + a aElk +++  +s ++++++  ++a +++++ +
       EFC36402.1 14 DAAVAELKKQRQSYVSYMIVVALVIAIATVGVVSYS 49
                     668899999999888877777766666666666554 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0018
  Phage_holin_3_6   30 akragsgagllgaagvlallalllllvalalal 62  
                        + + +  g+l++a +lal+++l++ + l++++
       EFC36402.1 1264 LRGLSISTGVLAGATALALVGVLVIGIILVWFV 1296
                       455555566666666666666666666665443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1089  (0.0607396); expected 358.6 (0.02)
Passed bias filter:                      691  (0.0385409); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.03u 0.34s 00:00:01.37 Elapsed: 00:00:00.55
# Mc/sec: 7326.58
//
Query:       EFC36403.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.7e-19   70.0   0.0      2e-18   66.6   0.0    1.9  2  adh_short     short chain dehydrogenase
    9.9e-11   41.6   0.0    1.3e-10   41.2   0.0    1.1  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    1.4e-07   31.6   0.0    1.8e-07   31.2   0.0    1.2  1  KR            KR domain


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.6   0.0   3.3e-22     2e-18       2     137 ..      11     153 ..      10     163 .. 0.89
   2 ?    1.7   0.0     0.025   1.5e+02     142     182 ..     182     227 ..     163     231 .] 0.83

  Alignments for each domain:
  == domain 1  score: 66.6 bits;  conditional E-value: 3.3e-22
                 EEEEESTTSHHHHHHHHHHHHT...T-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHHHHH.HHHSSESEEEE---SS--SSGG CS
   adh_short   2 vvlvtGassGIGraiakelake...Gakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealvekav.kklgkldvLvnNAGitgsgpfs 94 
                 +v+vtGa  G+G ++ak+l ++    ++vv++ r e++ +e+++ + +   ++++  i +D++d e+v+++v++ + +kl +l +Lv+NAGi    p  
  EFC36403.1  11 TVIVTGANCGLGFECAKQLFADeklEWHVVLACRDESRGKEALETILNGsvSDRISLILLDLSDLESVRKFVKEFEsAKLPPLKALVANAGI-VAPPKL 108
                 89*****************96522279****99************99988999********************9973578************.788889 PP

                 GCSHHHHHHHHHHHTHHHHHHHHHHHHHHH..HCTTEEEEEEEEG CS
   adh_short  95 elseeewervievNltgvflltravlpaml..kqssGrIvnvsSv 137
                  l+++ +e ++ vN  g fllt ++lp +   +++  +I  vsS 
  EFC36403.1 109 TLTKQGYEITVGVNHIGHFLLTNLLLPLFErdQKEINSIAVVSSE 153
                 999999**********************99755666777777776 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.025
                 B-TTBHHHHHHHHHHHHHHHHHHHHHGGGT.....EEEEEEEESSB CS
   adh_short 142 pvagvaaYsAsKaavagltrslakelaptg.....irvnavaPGlv 182
                 p + ++ Y +sK   + +t +l k l++++      rv++ +PG++
  EFC36403.1 182 PEEIGSRYPTSKLLNILFTYELWKRLQNSSefknqFRVTCFNPGFI 227
                 566778999999999999999999998876667789*******998 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.2   0.0   2.2e-14   1.3e-10       1     142 [.      16     164 ..      16     172 .. 0.85

  Alignments for each domain:
  == domain 1  score: 41.2 bits;  conditional E-value: 2.2e-14
                   TTTTSHHHHHHHHH.HHT..T-EEEEEESSGGH.HHHHHHHHHHTTSE.E..EE--TTSHHHHHHHHHHHHHHH.SSEEEEEE-----EGCSS-GGG CS
  adh_short_C2   1 GaasgIGraiAkal.aee..Gaevvltdlneea.kkrveelaeelgae.v..lecDVtdeeqvealveevvekf.gklDilvnnagiapklkgpfle 89 
                   Ga  g+G+++Ak+l a+e   ++vvl+ ++e++ k+++e++ +   ++ +  + +D +d e+v+++v+e ++     l  lv nagi+ +   p l+
    EFC36403.1  16 GANCGLGFECAKQLfADEklEWHVVLACRDESRgKEALETILNGSVSDrIslILLDLSDLESVRKFVKEFESAKlPPLKALVANAGIVAP---PKLT 109
                   7889*******987333322689**********9999999999766666668*****************986544***************...88** PP

                   H-HHHHHHHHHHHTHHHHHHHHHHHHHCTSC.CEEEEEEEGGGTSBSTTTT.HHH CS
  adh_short_C2  90 tsreefdraldvnlyslfllakaalplmkeg.gsivnlssvgaervvpnyn.ayg 142
                   +++++++ ++ vn  + fll++ +lpl+++    i  ++ v++e+  p+ +  + 
    EFC36403.1 110 LTKQGYEITVGVNHIGHFLLTNLLLPLFERDqKEINSIAVVSSEVHDPKLKiPMP 164
                   **************************99877588888899999988887765555 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2   0.0   3.1e-11   1.8e-07       2      96 ..      11     107 ..      10     132 .. 0.84

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 3.1e-11
                 EEEEETTTSHHHHHHHHHHHHHH..S-EEEEE-SS..--HHHHHHHHHHHHT.T-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE--------- CS
          KR   2 tylitGGlGgLGlelarwlaekg..arhlvllsRsaaadedskaliaeleal.gaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvlrdkl 96 
                 t+++tG+  gLG e a++l ++   + h+vl  R+  +++ ++al + l+ +   +++++ +D+sd ++v++ ++e+++ + pp+k  +  Ag+++  +
  EFC36403.1  11 TVIVTGANCGLGFECAKQLFADEklEWHVVLACRD--ESRGKEALETILNGSvSDRISLILLDLSDLESVRKFVKEFESAKlPPLKALVANAGIVAPPK 107
                 689****************96443499********..4555554555555543569**********************9999***********998655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       362  (0.0201908); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1420.74
//
Query:       EFC36404.1  [L=502]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.011   15.9   0.4      0.061   13.5   0.2    2.2  2  TFIID_NTD2  WD40 associated region in TFIID subunit, NTD2 dom


Domain annotation for each model (and alignments):
>> TFIID_NTD2  WD40 associated region in TFIID subunit, NTD2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.2   3.4e-06     0.061      66     125 ..      66     125 ..      53     130 .. 0.92
   2 ?   -1.2   0.0      0.12   2.2e+03      69      90 ..     270     291 ..     255     301 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.4e-06
                 GGHH.HHHHHTT--SHHHHHHSHHHHHHHHS-EEEEEEHHHHHHHHHHHHHTT-HHHHHH CS
  TFIID_NTD2  66 alhkedlkkLasisspehleenelakafrenkyriklskaafelLlrfLeekekavllki 125
                  +h++ +k+++ i ++ +le+n+l + f+++   i  +k++f+  +++L+ k+   +lk+
  EFC36404.1  66 IYHSASIKTMKDIGNKTNLETNPLHSWFQQELMAIDKEKESFDEYFYYLKGKKLVSMLKV 125
                 6899************************************************99988887 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.12
                 H.HHHHHTT--SHHHHHHSHHH CS
  TFIID_NTD2  69 kedlkkLasisspehleenela 90 
                  ++l++L+s+ + e++++  +a
  EFC36404.1 270 GKELENLSSVREIEDVKDYVVA 291
                 5678888888888888876555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       640  (0.0356964); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 3321.89
//
Query:       EFC36405.1  [L=281]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.7e-27   96.0   0.3    2.7e-27   95.4   0.3    1.3  1  Ras          Ras family
    2.2e-10   40.8   0.0    4.8e-10   39.7   0.0    1.6  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    5.5e-05   23.1   0.2       0.16   11.9   0.1    2.2  2  RsgA_GTPase  RsgA GTPase
    0.00085   18.9   0.1     0.0014   18.2   0.1    1.3  1  GTP_EFTU     Elongation factor Tu GTP binding domain
     0.0013   18.2   2.0      0.016   14.6   0.6    2.2  2  Gtr1_RagA    Gtr1/RagA G protein conserved region
     0.0019   18.0   0.3     0.0019   18.0   0.3    1.8  2  ATP_bind_1   Conserved hypothetical ATP binding protein
     0.0089   15.5   0.1      0.015   14.8   0.1    1.4  1  ParA         NUBPL iron-transfer P-loop NTPase
  ------ inclusion threshold ------
      0.015   14.8   0.9      0.043   13.4   0.1    2.0  2  FeoB_N       Ferrous iron transport protein B
       0.12   12.5   2.8        2.5    8.1   2.8    2.3  1  CbiA         CobQ/CobB/MinD/ParA nucleotide binding domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.4   0.3   1.3e-30   2.7e-27       1     158 [.      71     238 ..      71     241 .. 0.89

  Alignments for each domain:
  == domain 1  score: 95.4 bits;  conditional E-value: 1.3e-30
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K+v++G+++vGK+++++++++d F e+y++Ti +d y+k++ vdg    +e++D A   e++s r+ ++r +e+++lv d+ +++s e+++ +ve++ r
  EFC36405.1  71 KVVMIGKGGVGKSAMTVKYIQDFFIEQYDPTI-EDVYRKQLLVDGFPTLFEVLDSAE-HEYSSARDHFMRYGECFVLVCDLVDSNSVEEAEPLVEQLVR 167
                 9*******************************.***********************5.67*************************************** PP

                 HST...TTSEEEEEEETTTGGG..G-SS-HHH.HHHHH......HHHTSEEEEEBTTTTCTHHHHHHHHHH CS
         Ras 100 vae...envpivLvGnKvDlee..kravstee.geela......kelglkfletSAktnenveeafeellr 158
                 v++   +++p+v   nKvDl +  +r ++ e+  +++a      + +++  +etSAkt en+  ++ee++r
  EFC36405.1 168 VKDfeeNSFPVVFALNKVDLLNetDRPITIEKfTNQIAtiikqsQLTNTFIIETSAKTGENIIRVYEECVR 238
                 *9999889************88776777776623344455543233345668**************99987 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.7   0.0   2.4e-13   4.8e-10       1     119 [.      71     186 ..      71     187 .. 0.80

  Alignments for each domain:
  == domain 1  score: 39.7 bits;  conditional E-value: 2.4e-13
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 Kvv++G++gvGK+ +  ++++d f e++++ti  d+++k++  ++g+          +++ D a + +++s +++++r  ++++lv+d   s+s e+++
  EFC36405.1  71 KVVMIGKGGVGKSAMTVKYIQDFFIEQYDPTIE-DVYRKQL-LVDGF-------PTLFEVLDSAEH-EYSSARDHFMRYGECFVLVCDlvdSNSVEEAE 159
                 9*******************************8.5667776.36664.......3579****9965.68999**************9876566667777 PP

                 HHHHHH...HHHCSSS.-EEEEEE-TT CS
         Roc  97 eWlkel...kkvagks.pvilvgnkiD 119
                 + +++l   k+  ++s pv++  nk+D
  EFC36405.1 160 PLVEQLvrvKDFEENSfPVVFALNKVD 186
                 6666551115566676799999****9 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0   0.00051         1      97     117 ..      67      87 ..      35     102 .. 0.87
   2 !   11.9   0.1   7.9e-05      0.16      41      93 ..     170     232 ..     145     240 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00051
                  CTTSEEEEECSTTSSHHHHHH CS
  RsgA_GTPase  97 lkdktsvlvGqSGvGKStLin 117
                  +++  +v++G+ GvGKS++  
   EFC36405.1  67 IEKTKVVMIGKGGVGKSAMTV 87 
                  5667789**********9875 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 7.9e-05
                  HHHHTT-EEEEEEE-GGG--HHH..........HHHHHHHHHHHTTSEEEE--TTTHTTHHHH CS
  RsgA_GTPase  41 laeekgiepvivlnKiDlleeee..........eleelkeelealgyevllvsaktkegleel 93 
                   +ee+  ++v +lnK+Dll+e++          ++ ++ ++ + +++ ++ +sakt+e++ ++
   EFC36405.1 170 DFEENSFPVVFALNKVDLLNETDrpitiekftnQIATIIKQSQLTNTFIIETSAKTGENIIRV 232
                  46889999***************9998888877777888888888888888888888887665 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.1   6.8e-07    0.0014      73     190 ..     120     238 ..     102     258 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.8e-07
                 EEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB.....STHHHHHHHHH..HHHTTTEEEEEEESCGST.HHHHHHHHHHHHHHHHHHHHHHHHHHHT CS
    GTP_EFTU  73 nliDtPGHvdFskevirglrvlDgavlvvdaveG.....vepqteevlrl..alkegvpiivfiNKmDrl.kaelkeiveevkqklsrkeeklekygek 163
                  ++D+  H ++s+   + +r  ++ vlv+d v+       ep  e+++r+    ++  p+++++NK+D l +++   ++e+  +++    + +++ +  
  EFC36405.1 120 EVLDSAEH-EYSSARDHFMRYGECFVLVCDLVDSnsveeAEPLVEQLVRVkdFEENSFPVVFALNKVDLLnETDRPITIEKFTNQI---ATIIKQSQL- 213
                 56666655.5888888889999999***99996555555888888888772245667779**********7555555566666666...333433333. PP

                 TTTTEEEEEEBTTTTBTHHHHHHHHHH CS
    GTP_EFTU 164 gekevpvvfgSalkgegvktllealve 190
                   +++ ++ +Sa++ge++  + e +v+
  EFC36405.1 214 --TNTFIIETSAKTGENIIRVYEECVR 238
                 ..35789*********99966666554 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.034        68       1      16 [.      71      86 ..      71      98 .. 0.91
   2 !   14.6   0.6   8.1e-06     0.016      63     158 ..     126     222 ..     117     234 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.034
   Gtr1_RagA  1 kvLLmGksgsGKtsmr 16
                kv+++Gk+g GK++m 
  EFC36405.1 71 KVVMIGKGGVGKSAMT 86
                899***********96 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 8.1e-06
   Gtr1_RagA  63 eeylssqkeeifrnvgvliyVfDvesreleedletlkeilealrqyspeakvfvl.ihKmDliqedereeifeerkeeireeieklekeeiqffaTS 158
                 e+ +ss +++ +r  +  + V D  +++  e+ e l+e l ++++++++    v+ ++K+Dl++e  r  ++e+ +++i   i++ + +++ +  TS
  EFC36405.1 126 EHEYSSARDHFMRYGECFVLVCDLVDSNSVEEAEPLVEQLVRVKDFEENSFPVVFaLNKVDLLNETDRPITIEKFTNQIATIIKQSQLTNTFIIETS 222
                 566789999****************99999999999999999999998876555449***************************9998888777777 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.2      0.43   8.6e+02       2      17 ..      75      90 ..      74     104 .. 0.79
   2 !   18.0   0.3   9.6e-07    0.0019     116     187 ..     134     205 ..      84     241 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.43
  ATP_bind_1  2 vGpaGsGKttfvgals 17
                +G  G+GK+ ++ + +
  EFC36405.1 75 IGKGGVGKSAMTVKYI 90
                8999*****9976654 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 9.6e-07
  ATP_bind_1 116 eeLes..efalvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek.lekeleffedveals 187
                 +++++  e  + v  LvDs+ ++++  ++++ l+ ++   + + P v +lnk+Dll+e  +   +e f++   + 
  EFC36405.1 134 DHFMRygECFVLVCDLVDSNSVEEAEPLVEQ-LVRVKDFEENSFPVVFALNKVDLLNETdRPITIEKFTNQ--IA 205
                 556655667778888****************.9************************88888888888854..22 PP

>> ParA  NUBPL iron-transfer P-loop NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.1   7.5e-06     0.015       2      23 ..      67      88 ..      66     105 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 7.5e-06
        ParA  2 vkkviavlSgKGGVGKStvavn 23
                ++k+ +v+ gKGGVGKS ++v+
  EFC36405.1 67 IEKTKVVMIGKGGVGKSAMTVK 88
                6677899*************97 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.49   9.7e+02       2      16 ..      71      85 ..      70      91 .. 0.87
   2 ?   13.4   0.1   2.1e-05     0.043      54     136 ..     115     206 ..      95     235 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.49
                EEEEEESTTSSHHHH CS
      FeoB_N  2 tvalvGnpnvGkttl 16
                +v+++G+  vGk+++
  EFC36405.1 71 KVVMIGKGGVGKSAM 85
                799*********987 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 2.1e-05
                 ----SSS.SSSSHHHHHHHHHHH..CTSSSEEEEEEEGGGHHHHHHHHHHHH......HTTSSEEEEEETHHHHHHTTEEE-HHHHHHHHTS CS
      FeoB_N  54 lPGiYsl.sayseeekvardfll..eeepdvvvnvvdatnlernLyLtlqll......elgvpvvlalnmideaekkgieidlkkLsekLgv 136
                 +P  +++ ++  +e + ard ++   e + +v ++vd++++e    L+ ql+      e + pvv aln++d ++++   i ++k+++++ +
  EFC36405.1 115 FPTLFEVlDSAEHEYSSARDHFMryGECFVLVCDLVDSNSVEEAEPLVEQLVrvkdfeENSFPVVFALNKVDLLNETDRPITIEKFTNQIAT 206
                 555565413344444566666663334556677899999999988888888723322245689***************99999999887754 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   2.8    0.0013       2.5       2      28 ..      72      98 ..      71     271 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0013
                EEEESSTTSSHHHHHHHHHHHHHHTT- CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        CbiA  2 aiastkGGvGKTtlaanLaralarrgl 28
                +++ +kGGvGK+ ++++ ++ +  +++
  EFC36405.1 72 VVMIGKGGVGKSAMTVKYIQDFFIEQY 98
                57789**********998887765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (281 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       696  (0.0388198); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1813.90
//
Query:       EFC36406.1  [L=488]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.9e-23   80.7   0.0    1.5e-22   80.1   0.0    1.3  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    2.5e-17   63.2   0.0    6.9e-17   61.8   0.0    1.8  2  GTP_EFTU_D3  Elongation factor Tu C-terminal domain
    0.00015   22.1   0.0    0.00043   20.6   0.0    1.9  1  GTP_EFTU_D2  Elongation factor Tu domain 2
     0.0045   17.1   0.0      0.067   13.3   0.0    2.3  1  MMR_HSR1     50S ribosome-binding GTPase
  ------ inclusion threshold ------
       0.02   14.2   0.1      0.036   13.4   0.1    1.4  1  Gtr1_RagA    Gtr1/RagA G protein conserved region
        0.1   11.8   0.0       0.54    9.5   0.0    1.9  1  Septin       Septin
       0.11   12.6   0.0       0.28   11.3   0.0    1.7  1  RE_R_Pab1    R.Pab1 restriction endonuclease


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.1   0.0   5.8e-26   1.5e-22       5     182 ..      13     222 ..      10     307 .. 0.86

  Alignments for each domain:
  == domain 1  score: 80.1 bits;  conditional E-value: 5.8e-26
                 EEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH...HHHST............................HCHSHHHHHHTSCSSCEEEEEETTCSSEEE CS
    GTP_EFTU   5 nigiighvDhGKtTLtdrLlyktgaiskkgeka...eeerv............................lDtlkeErergiTiksaaisleketkkyli 72 
                 n+++ig vD GK+TL ++L+ k +    ++ k+       +                            +   ++  er i+ +++a ++  e + +++
  EFC36406.1  13 NLVLIGFVDCGKSTLGGQLVRKIKPQVYEQLKRqceL---YqqgqqaifqrfgiqswmgnrnhfhisslMLDSPTQAEREISTDVNAKHVI-ELSACQF 107
                 999*****************99987776666554540...244566789********************8888999***********9999.9****** PP

                 EEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB..........STHHHHHHHHHHHHTTTE.EEEEEESCGST...HHHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  73 nliDtPGHvdFskevirglrvlDgavlvvdaveG..........vepqteevlrlalkegvp.iivfiNKmDrl...kaelkeiveevkqklsrkeekl 157
                  +iDtPGH dF+k++i+g+++ +++++vv+a++G               ++ l   +  g++ +iv++NKmD +   ++++ ei++ +  kl      +
  EFC36406.1 108 RIIDTPGHGDFIKKTIQGISMGNVCLMVVSASDGefeagfhrenLSFSYKQQLIYSKVAGIErFIVCVNKMDCVkysEKRFLEIKTSIG-KL------I 199
                 **********************************99999997777777777777777788889************9999*********9.77......7 PP

                 HHHHHTTTTTEEEEEEBTTTTBTHH CS
    GTP_EFTU 158 ekygekgekevpvvfgSalkgegvk 182
                 + +g k+  e+p++++++  g++v 
  EFC36406.1 200 KTVGIKQ--EIPFIPICGECGDNVF 222
                 8899997..5*******99999876 PP

>> GTP_EFTU_D3  Elongation factor Tu C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.8   9.7e+03      45      72 ..      31      58 ..      28      60 .. 0.79
   2 !   61.8   0.0   2.7e-20   6.9e-17       2     111 ..     346     455 ..     345     456 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.8
                 EEECCSSTTSB-BSS-SSCCSTT-CEEE CS
  GTP_EFTU_D3 45 LlskldkktekvsekkpefvkpGdnviv 72
                 L++k++++  ++ +++ e+ ++G+++i+
   EFC36406.1 31 LVRKIKPQVYEQLKRQCELYQQGQQAIF 58
                 6778888888888889999999998876 PP

  == domain 2  score: 61.8 bits;  conditional E-value: 2.7e-20
                  -EEECCEEEEEEESSS..SS-BSTT-EEEEESSS-EEEEEEEEEEECCSSTTSB-.BSS-SSCCSTT-CEEEEEEECCEEEE--TTTHCCCCEEEEEC CS
  GTP_EFTU_D3   2 ikphtkfeAqvyilekerhtpitagYrpvlyirtadvtgkvveLlskldkktekv.sekkpefvkpGdnvivevelikpialekgseypqlGrFaiRe 98 
                  +k++++f Aq+ i++   +  i agY+p+ ++  a  + k+++L+  l++  ++   e++p+ +  Gd + ve+ ++ p+ ++++++ ++lGr  iR+
   EFC36406.1 346 CKAASRFIAQISIINT-PKPSIRAGYAPIVHCGLAFANTKFEKLIGILNPTDSSIiIEENPSCLEIGDVALVELAPTVPLFVDSYNDCNKLGRIIIRD 442
                  7899************.6778*************************9999877652689*************************************** PP

                  TTCEEEEEEEEEE CS
  GTP_EFTU_D3  99 ggrTvaaGvvtei 111
                  g+ T+a+G+++++
   EFC36406.1 443 GRATIAVGTIVKV 455
                  **********998 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   1.7e-07   0.00043       5      54 ..     274     322 ..     271     387 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.7e-07
                  EEEEEESEEETTEEEEEEC.TCTTSEE.EEEEEEEEEEETEEESEEETTSEE CS
  GTP_EFTU_D2   5 lgrvysGtlkkGdevrilg.ndtskke.ivtrissletfhededeavagana 54 
                   g ++sG +k+G++v i + +++ + e i +r++ ++ +h +++ a     +
   EFC36406.1 274 AGYIISGMVKVGMTVQI-PrVHS-G-ElINVRVKNIQISHTNKERAFSNSLV 322
                  689**************.54655.3.36*************99988554444 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   2.6e-05     0.067       2      87 ..      14     144 ..      13     177 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.6e-05
                 EEEEESTTSSHHHHHHHHHTS.TEEESSSTTSSSSE.EEEEEEETTEE................................................... CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltge.kaivsdkpgtTrdi.negrvklkgke................................................... 47 
                  +++G    GKStL  +l+++ k +v ++     +  ++g+      +                                                   
  EFC36406.1  14 LVLIGFVDCGKSTLGGQLVRKiKPQVYEQLKRQCELyQQGQ------Qaifqrfgiqswmgnrnhfhisslmldsptqaereistdvnakhvielsacq 106
                 5899***************9655555333322222213332......1122233334445555677888888888888888888888888898988988 PP

                 EEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT....T CS
    MMR_HSR1  48 ielvDtpGliegaseekglgkaflaleeadlillvvdas....e 87 
                 ++++DtpG          ++k+++ +   ++ l+vv+as    e
  EFC36406.1 107 FRIIDTPG-HG-----DFIKKTIQGISMGNVCLMVVSASdgefE 144
                 ********.33.....3355555554445788888887744441 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   1.4e-05     0.036      32     148 ..      89     203 ..      14     217 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.4e-05
   Gtr1_RagA  32 gatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletlkeilealrqyspea.kvfvlihKmDliqede 128
                 ++++dv+ ++v  l+  ++ ++D +G  +f++++   q  ++ + +  ++   D e +  ++++  +++   + ++     + ++ v ++KmD ++   
  EFC36406.1  89 EISTDVNAKHVIELSACQFRIIDTPGHGDFIKKT--IQGISMGNVCLMVVSASDGEFEAgFHRENLSFSYKQQLIYSKVAGIeRFIVCVNKMDCVK--Y 183
                 56779****************************7..77777777666666667777554455555556555555655555552456789******5..5 PP

   Gtr1_RagA 129 reeifeerkeeireeiekle 148
                  e+ f e+k++i + i+ ++
  EFC36406.1 184 SEKRFLEIKTSIGKLIKTVG 203
                 56677788888887777665 PP

>> Septin  Septin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00021      0.54       4      77 ..      11     120 ..       8     128 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00021
                 EEEEEEEEBTTSSCCCCCCTTSSS...S----...................................--------------S-E.EEEEEEEETTCEEE CS
      Septin   4 eftlmvvGesglGkttlintlfet...dliee...................................ekleeasekkkktveik.kkkvvieedgvkln 63 
                 ef+l+++G    Gk+tl   l+++   +++e+                                     l++++ +++++++ + ++k+vie      +
  EFC36406.1  11 EFNLVLIGFVDCGKSTLGGQLVRKikpQVYEQlkrqcelyqqgqqaifqrfgiqswmgnrnhfhissLMLDSPT-QAEREISTDvNAKHVIELS--ACQ 106
                 67888888888888888777765422133333777788888888888888888888887777766532223333.3333444442445555555..567 PP

                 EEEEE---BSSSSS CS
      Septin  64 ltviDtpgfGdavd 77 
                 + +iDtpg+Gd++ 
  EFC36406.1 107 FRIIDTPGHGDFIK 120
                 889********997 PP

>> RE_R_Pab1  R.Pab1 restriction endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00011      0.28       3      57 ..     400     454 ..     398     472 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00011
   RE_R_Pab1   3 ilrerfiskkilGvefeesrvkypllvhkfddfdvlveivikekqravkvqamly 57 
                 i+ e++   +i+ v + e     pl+v +++d ++l  i+i++ + ++ v +++ 
  EFC36406.1 400 IIEENPSCLEIGDVALVELAPTVPLFVDSYNDCNKLGRIIIRDGRATIAVGTIVK 454
                 56677777788888888888899*******************9988877766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      533  (0.0297284); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 3005.85
//
Query:       EFC36407.1  [L=843]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-43  147.2 230.7    8.3e-06   26.1   7.2   13.7 13  EGF_2     EGF-like domain
    1.9e-07   31.2 189.1       0.14   12.5   8.4   13.9 13  EGF       EGF-like domain
  ------ inclusion threshold ------
      0.016   15.8   1.0        2.3    8.8   0.0    3.2  3  B_lectin  D-mannose binding lectin


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   4.2   1.2e-06    0.0069       5      28 ..      34      56 ..      30      58 .. 0.80
   2 !   26.1   7.2   1.4e-09   8.3e-06       5      32 .]     206     232 ..     202     232 .. 0.91
   3 !   13.4   7.4   1.3e-05     0.077       4      30 ..     240     265 ..     237     266 .. 0.84
   4 !   18.0  16.0   4.5e-07    0.0027       6      32 .]     277     302 ..     273     302 .. 0.86
   5 !   20.6   8.8   7.4e-08   0.00044       6      30 ..     311     334 ..     307     335 .. 0.82
   6 !   20.5  11.1   7.6e-08   0.00046       1      30 [.     342     369 ..     342     372 .. 0.82
   7 !   14.1  11.9   7.7e-06     0.046       6      29 ..     381     403 ..     372     407 .. 0.80
   8 !   18.3  10.2   3.6e-07    0.0022       6      30 ..     416     439 ..     412     440 .. 0.85
   9 !   14.8  14.6   4.7e-06     0.028       1      30 [.     447     474 ..     447     477 .. 0.83
  10 !   10.3  10.6   0.00012      0.73       1      30 [.     482     509 ..     482     510 .. 0.83
  11 !   15.9   9.4     2e-06     0.012       6      30 ..     521     544 ..     517     545 .. 0.86
  12 !   18.6  12.9   2.9e-07    0.0018       1      30 [.     552     579 ..     547     580 .. 0.84
  13 !   14.0  11.9   8.2e-06     0.049       1      28 [.     587     612 ..     582     616 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.2e-06
       EGF_2  5 deiCgghGtCvnqcGqCdC.dsgyq 28
                ++ Cg hG+C+   G C+C ds yq
  EFC36407.1 34 QDSCGSHGVCN--YGTCYCvDSVYQ 56
                567********..******555444 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 1.4e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG+C +++ +C+C++gy+G++C
  EFC36407.1 206 SLVCSGHGSCPSPN-NCVCSDGYHGNKC 232
                 688*******9999.8************ PP

  == domain 3  score: 13.4 bits;  conditional E-value: 1.3e-05
       EGF_2   4 sdeiCgg.hGtCvnqcGqCdCdsgyqGk 30 
                 + ++C+  hG+C++++  C+C+sg+ G+
  EFC36407.1 240 R-DNCSLdHGSCISAN-TCSCQSGWKGN 265
                 4.569988*****888.9*******996 PP

  == domain 4  score: 18.0 bits;  conditional E-value: 4.5e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ghG+Cv+ +  C+Cd+ ++G +C
  EFC36407.1 277 NYCSGHGQCVSNN-TCQCDDYWHGENC 302
                 79*******9555.9***********9 PP

  == domain 5  score: 20.6 bits;  conditional E-value: 7.4e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C+ghG+Cv+ +  C+C sg+ G+
  EFC36407.1 311 DNCNGHGSCVSNN-TCMCYSGWKGD 334
                 57*******9555.9*********8 PP

  == domain 6  score: 20.5 bits;  conditional E-value: 7.6e-08
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C+a  + C++hG+Cv+ +  C+C+sg+ G+
  EFC36407.1 342 CEAL-NHCNNHGQCVSNN-SCECNSGWKGN 369
                 6664.78*******9666.7********97 PP

  == domain 7  score: 14.1 bits;  conditional E-value: 7.7e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqG 29 
                 + C+ghG+C++ +  C+C+sg+  
  EFC36407.1 381 NHCSGHGSCISNN-TCSCESGWKS 403
                 67*******9555.9*******75 PP

  == domain 8  score: 18.3 bits;  conditional E-value: 3.6e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C+g+G+Cv+ +  C+C++g+ G+
  EFC36407.1 416 NECNGNGHCVSNN-TCECNNGWLGN 439
                 78*******9555.9********97 PP

  == domain 9  score: 14.8 bits;  conditional E-value: 4.7e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C++  ++C+ghG+Cv+ +  C+C+sg+ G+
  EFC36407.1 447 CETL-NNCSGHGQCVSNN-SCSCESGFKGN 474
                 6664.78*******9666.7********96 PP

  == domain 10  score: 10.3 bits;  conditional E-value: 0.00012
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C a  ++C g+G Cv+ +  C+C+ g+ G+
  EFC36407.1 482 CDAL-NDCYGNGNCVSNN-TCECQVGWKGN 509
                 6554.78*******9555.9********97 PP

  == domain 11  score: 15.9 bits;  conditional E-value: 2e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C+ hG Cv+ +  C+C sg+ G+
  EFC36407.1 521 NNCSHHGDCVSNN-TCSCHSGWRGN 544
                 57*******9555.9********97 PP

  == domain 12  score: 18.6 bits;  conditional E-value: 2.9e-07
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C a  ++C+ghG+Cv+ +  C+C+sg+ G+
  EFC36407.1 552 CDA-LNECSGHGSCVSNN-SCECNSGWKGN 579
                 555.389*******9666.7********97 PP

  == domain 13  score: 14.0 bits;  conditional E-value: 8.2e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyq 28 
                 C a  ++C++hGtC++ +  C+C++++ 
  EFC36407.1 587 CDAL-SNCSNHGTCISNN-TCSCNTHWK 612
                 4443.67*******9555.9******95 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   2.7      0.27   1.6e+03       6      24 ..      37      50 ..      32      56 .. 0.59
   2 !    6.9   5.2    0.0013       7.7       6      31 ..     209     230 ..     204     231 .. 0.86
   3 !    6.8   1.6    0.0014       8.6       9      31 ..     247     265 ..     240     266 .. 0.84
   4 ?    2.2   9.4     0.039   2.3e+02       1      31 [.     273     300 ..     273     301 .. 0.82
   5 !   11.2   6.9   5.8e-05      0.34       1      31 [.     307     334 ..     307     335 .. 0.91
   6 !   11.9   9.3   3.5e-05      0.21       1      31 [.     342     369 ..     342     370 .. 0.92
   7 !    9.6   7.4   0.00019       1.1       1      29 [.     377     402 ..     377     404 .. 0.94
   8 !    5.0   9.5    0.0053        32       1      28 [.     412     436 ..     412     440 .. 0.84
   9 !   11.7   9.2   4.2e-05      0.25       1      31 [.     447     474 ..     447     475 .. 0.92
  10 !    9.8   8.4   0.00017      0.99       1      31 [.     482     509 ..     482     510 .. 0.90
  11 !   12.5   8.4   2.3e-05      0.14       1      31 [.     517     544 ..     517     545 .. 0.93
  12 !   12.1   7.8   3.1e-05      0.18       1      31 [.     552     579 ..     552     580 .. 0.90
  13 !    7.1   8.1    0.0011       6.8       1      28 [.     587     611 ..     587     612 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.27
                STTT-EEEEETTTEEEEEE CS
         EGF  6 CsngGtCvdtgrggytCiC 24
                C  +G C ++g    tC C
  EFC36407.1 37 CGSHGVC-NYG----TCYC 50
                5555555.444....4544 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0013
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C   +    +C C+ Gy+G+
  EFC36407.1 209 CSGHGSC---P-SPNNCVCSDGYHGN 230
                 *******...6.6789*********7 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0014
                 T-EEEEETTTEEEEEECTTEEST CS
         EGF   9 gGtCvdtgrggytCiCpeGytGk 31 
                 +G C++      tC C++G++G+
  EFC36407.1 247 HGSCISAN----TCSCQSGWKGN 265
                 67787777....*********97 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.039
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  n Cs++G Cv++     tC+C+  ++G+
  EFC36407.1 273 CDGvNYCSGHGQCVSNN----TCQCDDYWHGE 300
                 776566**********9....****9777766 PP

  == domain 5  score: 11.2 bits;  conditional E-value: 5.8e-05
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   ++C+++G Cv++     tC C +G++G+
  EFC36407.1 307 CELvDNCNGHGSCVSNN----TCMCYSGWKGD 334
                 677689***********....*********96 PP

  == domain 6  score: 11.9 bits;  conditional E-value: 3.5e-05
                 GCSTT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 C   + C+n+G Cv++     +C+C +G++G+
  EFC36407.1 342 CEALNhCNNHGQCVSNN----SCECNSGWKGN 369
                 888788*******9999....*********97 PP

  == domain 7  score: 9.6 bits;  conditional E-value: 0.00019
                 GCSTT.STTT-EEEEETTTEEEEEECTTEE CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGyt 29 
                 C++ + Cs++G C+++     tC C +G++
  EFC36407.1 377 CDSLNhCSGHGSCISNN----TCSCESGWK 402
                 9**888*******9999....*******95 PP

  == domain 8  score: 5.0 bits;  conditional E-value: 0.0053
                 GCS.TTSTTT-EEEEETTTEEEEEECTTE CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGy 28 
                 C   n C+++G Cv++     tC+C +G+
  EFC36407.1 412 CEVlNECNGNGHCVSNN----TCECNNGW 436
                 666355***********....*******9 PP

  == domain 9  score: 11.7 bits;  conditional E-value: 4.2e-05
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   n+Cs++G Cv++     +C C +G++G+
  EFC36407.1 447 CETlNNCSGHGQCVSNN----SCSCESGFKGN 474
                 888688*******9999....*********96 PP

  == domain 10  score: 9.8 bits;  conditional E-value: 0.00017
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  n C ++G Cv++     tC+C++G++G+
  EFC36407.1 482 CDAlNDCYGNGNCVSNN----TCECQVGWKGN 509
                 888455***********....*********97 PP

  == domain 11  score: 12.5 bits;  conditional E-value: 2.3e-05
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   n+Cs++G Cv++     tC C +G+ G+
  EFC36407.1 517 CEIlNNCSHHGDCVSNN----TCSCHSGWRGN 544
                 888788***********....*********97 PP

  == domain 12  score: 12.1 bits;  conditional E-value: 3.1e-05
                 GCSTT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  + Cs++G Cv++     +C+C +G++G+
  EFC36407.1 552 CDALNeCSGHGSCVSNN----SCECNSGWKGN 579
                 889555*******9999....*********97 PP

  == domain 13  score: 7.1 bits;  conditional E-value: 0.0011
                 GCS.TTSTTT-EEEEETTTEEEEEECTTE CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGy 28 
                 C+   +Csn+GtC+++     tC C +++
  EFC36407.1 587 CDAlSNCSNHGTCISNN----TCSCNTHW 611
                 666568*******9999....****8876 PP

>> B_lectin  D-mannose binding lectin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.023   1.4e+02       4      64 ..      63     131 ..      61     140 .. 0.64
   2 ?    8.8   0.0   0.00038       2.3      18      45 ..     153     180 ..     143     189 .. 0.78
   3 ?   -1.5   0.2      0.62   3.7e+03      25      43 ..     671     688 ..     625     715 .. 0.56

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.023
    B_lectin   4 WVaNrekPi........kdssgvlkisedgnLvllnesksvvwstssssssakntvaqLldsGnLvles 64 
                 W a+r + +        +d + +l+++++g L l+n+ +    ++ +++  +   v+ L  +G L ++ 
  EFC36407.1  63 WTADRRQTLvqgeslvsTDGTFTLAMKSSGVLSLMNSITAEEKKSYTATGGSGPYVLALATDGSLSIKG 131
                 888888888643333333333458888888888888876555555566667777777788888877744 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00038
    B_lectin  18 vlkisedgnLvllnesksvvwstsssss 45 
                 +l +++dgnLvl+ ++++v w t++ ++
  EFC36407.1 153 RLVLQNDGNLVLYGAQEEVCWETHTWTA 180
                 5788999999999999999999955444 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.62
    B_lectin  25 gnLvllnesksvvwstsss 43 
                 ++  l  +s+s  +st ss
  EFC36407.1 671 STFGLNLSSNSFYFST-SS 688
                 2333333334444555.22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (843 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1366  (0.0761894); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.00u 0.31s 00:00:01.31 Elapsed: 00:00:00.51
# Mc/sec: 4986.65
//
Query:       EFC36408.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1024  (0.0571142); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1039.99
//
Query:       EFC36409.1  [L=973]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (973 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1609  (0.0897429); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.77u 0.29s 00:00:01.06 Elapsed: 00:00:00.46
# Mc/sec: 6334.31
//
Query:       EFC36410.1  [L=424]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (424 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       957  (0.0533772); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.27s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2475.86
//
Query:       EFC36411.1  [L=629]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.043   13.1   2.5        0.5    9.5   2.5    2.1  1  Plavaka   Plavaka transposase


Domain annotation for each model (and alignments):
>> Plavaka  Plavaka transposase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   2.5   2.8e-05       0.5     210     270 ..     176     251 ..     145     340 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 2.8e-05
     Plavaka 210 hvrrvipilaayiaDypEqvlvacivqgwCpkctakkkelgdl.ee..............selrtreetlelleea 270
                    + +++ + +  D+pE++   + ++++C++c   +++l+++ ++              +++r+++e+++++e+ 
  EFC36411.1 176 EDIKLFICCMGFLLDTPERLKCLALMKNECSRCLDASDNLDKTpTDlmgasafnptcvhtFKRREHSEMKDIVEKL 251
                 5556777888999***************************995322222222322322223555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (629 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       975  (0.0543812); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 3668.57
//
Query:       EFC36412.1  [L=781]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00076   19.6   0.1    0.00076   19.6   0.1    2.8  4  F5_F8_type_C  F5/8 type C domain


Domain annotation for each model (and alignments):
>> F5_F8_type_C  F5/8 type C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       0.4   7.2e+03      57      77 ..     210     229 ..     201     251 .. 0.59
   2 !   19.6   0.1   4.2e-08   0.00076      23     110 ..     339     422 ..     314     433 .. 0.71
   3 ?   -2.3   0.1      0.25   4.5e+03      64      82 ..     543     561 ..     515     585 .. 0.56
   4 ?   -2.8   0.0      0.35   6.4e+03      71     110 ..     699     741 ..     693     753 .. 0.64

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.4
                   STTSSEEEEEEEEEESSSSSE CS
  F5_F8_type_C  57 dggnayvksykiqvsddgetW 77 
                   +++++++ +y + v++   t+
    EFC36412.1 210 NSADDFAANYDVKVTSTK-TF 229
                   333555555555554432.33 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 4.2e-08
                   TSSEEESSSSTTEEEEEEEEEEEEEEEEEEEECSSTT..SSEEEEEEEEEESSSSSEEEEEEECEEESSSSSSSEEEEEEEEEEEEEEEE CS
  F5_F8_type_C  23 ntaWsssssddkqwlqvdLgkpkkidgvvtqgrqdgg..nayvksykiqvsddgetWttvkdekvpgnsdnstpvtntfdppvkaryvrl 110
                   n++  +++s++ + +q  ++ p++++g+v+++   +g  + y     + +s+d  +W++v +   +g +d  + +t  ++ +++a y r+
    EFC36412.1 339 NSGA-ATNSNSRPFVQATFEHPHTVTGIVVKPLLVSGwgSTYLAGSYLAYSQDEINWKNVLQ--LNGLTD--GLTTFVVP-SISAPYWRI 422
                   3333.3344444*******************97555559**********************9..444333..44444444.888887766 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 0.25
                   EEEEEEEESSSSSEEEEEE CS
  F5_F8_type_C  64 ksykiqvsddgetWttvkd 82 
                    + ++  +++ ++W + ++
    EFC36412.1 543 VKIEMAHKNQADEWVEMQN 561
                   3333333444456666666 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 0.35
                   ESSSSSEEEEEE..ECEEESSSSSSSEEEEEE.EEEEEEEEEE CS
  F5_F8_type_C  71 sddgetWttvkd..ekvpgnsdnstpvtntfd.ppvkaryvrl 110
                   s++g t+ +v+d  +k  + ++++++++++++      r+v +
    EFC36412.1 699 SSNGYTYSYVYDefQKFMEKAKKEGKKEIELEdGKSDNRHVYM 741
                   5667888888886655544444567777777755555566655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (781 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       753  (0.041999); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.35s 00:00:01.08 Elapsed: 00:00:00.53
# Mc/sec: 4447.07
//
Query:       EFC36413.1  [L=556]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.017   15.1   0.1      0.049   13.6   0.0    1.7  1  Gag_p17        gag gene protein p17 (matrix protein)
       0.04   14.3   0.1      0.091   13.2   0.1    1.6  1  FERM_C         FERM C-terminal PH-like domain
      0.056   13.6   2.3       0.15   12.2   2.3    1.7  1  Orthopox_A36R  Orthopoxvirus A36R protein


Domain annotation for each model (and alignments):
>> Gag_p17  gag gene protein p17 (matrix protein)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   8.2e-06     0.049      72     136 ..     100     165 ..      90     169 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 8.2e-06
     Gag_p17  72 eglrslyntvavllcvhqeikvkdtkealekvkreqnkskkktevtsgsaqqkaaag.gtaasagv 136
                 e   s+yn++  l+ +hq++ ++      ++ k  ++k  k  e+++++++++++ag g++++ g+
  EFC36413.1 100 EYASSVYNLIKELYLIHQSKPLEKVSLDEKNKKYLEGKMPKLDESATPTEEKQNSAGtGSSTPKGI 165
                 55679***************9998766555555556666666666666666555554266676665 PP

>> FERM_C  FERM C-terminal PH-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   1.5e-05     0.091      12      82 ..      45     112 ..      39     123 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.5e-05
                 -SSE.EEEEBTTBSS.S-SEEEEGGGEEEEEEETTEEEEEES...STTS--.EEEE-S-HHHHHHHHHHHHHH CS
      FERM_C  12 sakG.ilvyekqnki.tpklafpWreieklsfkdkkfsielrseeqkkreellsFtaqtskacktlwklcveq 82 
                  +kG +++++++  + +pk a + ++i+ l+  +kk si+l+      +++ + +++++ + + ++++l +e 
  EFC36413.1  45 LSKGtLYICKDRILCkKPKVALEYKQIQSLNCVKKKVSIKLD-----DSKTEHDLKCKSMEYASSVYNLIKEL 112
                 55664789999999999*************************.....66777788888888888888777664 PP

>> Orthopox_A36R  Orthopoxvirus A36R protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   2.3   2.5e-05      0.15      11      83 ..      39     111 ..      31     126 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.5e-05
  Orthopox_A36R  11 vvagtilvcyilyicrkkirtvyndnkiimtklkkikssnssk...sskstdsesdwedhcsameqnndvdnisrn 83 
                     v g+il    lyic+ +i    +  k+     k+i+s n  k   s k  ds+++ + +c +me    v n+ ++
     EFC36413.1  39 DVKGSILSKGTLYICKDRILC--KKPKVA-LEYKQIQSLNCVKkkvSIKLDDSKTEHDLKCKSMEYASSVYNLIKE 111
                    5899***********998755..556655.46788888888762335577899999999**********9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (556 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       762  (0.042501); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 3598.73
//
Query:       EFC36414.1  [L=425]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (425 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1395  (0.0778069); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.97u 0.36s 00:00:01.33 Elapsed: 00:00:00.55
# Mc/sec: 2345.09
//
Query:       EFC36415.1  [L=1324]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-59  202.1   0.0    2.1e-59  201.3   0.0    1.4  1  AMP-binding     AMP-binding enzyme
    7.5e-54  182.6   0.0    1.3e-53  181.8   0.0    1.4  1  NAD_binding_4   Male sterility protein
     0.0047   16.4   0.0      0.013   14.9   0.0    1.8  1  Epimerase       NAD dependent epimerase/dehydratase family
  ------ inclusion threshold ------
      0.071   12.9   2.2       0.21   11.4   0.2    2.7  2  Synaptonemal_3  Synaptonemal complex central element protein 
       0.13   12.6   0.0        0.3   11.5   0.0    1.6  1  PP-binding      Phosphopantetheine attachment site
       0.34   11.0   3.5         23    5.1   0.0    3.4  3  N-SET           COMPASS (Complex proteins associated with Set


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  201.3   0.0   6.9e-63   2.1e-59      17     423 .]     152     629 ..     139     629 .. 0.86

  Alignments for each domain:
  == domain 1  score: 201.3 bits;  conditional E-value: 6.9e-63
                  CCSTEEEEHHHHHHHHHHHHHHHH.HT.TSSTT-E...EEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHHTESEEEETCTCCCHHH CS
  AMP-binding  17 sgegqtlTYreldervnrlAagLr.sl.Gvkkgdr...VaillpnspewvvallailkaGavvvplnptltaeelayiledseakvliatvdsellek 109
                  +g +++l Y+++ + v+ +A gL   l  ++++++   V i+ +n + w++ ++a++  G v++p+  + t +e ++i+e ++++v++  +  e l+ 
   EFC36415.1 152 DGPYHWLRYEQVFHLVCCIAVGLDeILkPLREENKrqfVSICGKNNLYWYLCDYACFFKGFVAAPIHFAQTFDETKHIVELTDSQVVV--CTLEMLDF 247
                  57899******************964423343333566**************************************************..88888999 PP

                  HHHHHSCC-EECEEEEESCCS-HCCHCCCHCCCCSCTTS........................................................... CS
  AMP-binding 110 lleaaakleavklvivldadellkeeelkeeeeseekae........................................................... 148
                    +++++l+ vk ++v+d++e + ++++ ++++++e +                                                            
   EFC36415.1 248 FISITKQLDFVKYIVVMDDNEGKSKSKFTTNSGKQEIEIlpmneiidkgksilceylneknkpkkkrypkhfenhetilvtpknkynpnkmwidvehq 345
                  9999**************999999999998888887772567889999*************************************************9 PP

                  ...-TSCCCS-BTTSEEEEEEE--SSSS-EEEEEEHHHHHHHHHHHHHHHCSCCTTT-EEEESS-TTSCHHHHHHHHHHHHTT-EEEE-TTCGCCHHH CS
  AMP-binding 149 ...kpeeeeelkpddlayiiYTSGTTGkPKGVmlshrnlvanvaslkletrfklkeddvvlsilplahifglilelllallsGatvvllpkdaaldpk 243
                         ++  k +dl+ +++TSG+TG+PKG+m+s ++l   ++ +       +++ +v +s+ plah+      +lla++ Ga+v+++++d      
   EFC36415.1 346 dfiL---NRLEKDEDLLSLVFTSGSTGQPKGIMVSDKSLRREMHGFR------AENPKVQFSFCPLAHMSDR-KHTLLAMCDGARVGIFTRDFV---- 429
                  6542...445688*****************************99973......22335679**********6.***************996633.... PP

                  HHHHHHHHHT-SEEEEEHHHHHHHHH.CCCHHCHHHHC.............................CGTT.-SEEEEESS-EBHHHHHHHHHHHTCE CS
  AMP-binding 244 lllelieklkvtviagvPrvlealle.sgalkaakkak.............................dlss.lrlvllggeplspellrffralfgee 310
                  +++e+i+k k+tvia++Pr+++ l +  ++ ++ +k +                              l++ l+ +++gg++ sp++ +f+ ++f + 
   EFC36415.1 430 HIFEDIQKVKPTVIASTPRLYNVLYDeYKKVYELEKTSwlsgisnqnedrpktereleervmkdfrnMLGGrLQSIIIGGASSSPQVREFLGKCFNCF 527
                  478*********************664444442222224455555555556666666666777777677777999*********************** PP

                  EEEEEEEGGGSSECEECHCTTTCTSTTS-BEE-TTEEEEEE-TTTSCBEETTSE...EEEEEEETTS-SEBTT-HHHHHHHEEETCCEEEEEEEEEEE CS
  AMP-binding 311 vlegYGlTEttgvvtvlpleedkkklgsvGkplpgvevkivDeetgepvpdgee...GellvrgpgvmkgYlkkpeataeafdsegrwlrTGDlgrld 405
                  v++g+G++E++g++  ++   +             ve+k+vD  +++++ ++++   Gel+v+ ++++ gY+k++e+t+ a+d e++wl+T D+++  
   EFC36415.1 528 VSDGFGMSEAGGIMN-DN---R---------LHSSVEYKLVDVPDMNYFTNDKPyprGELCVKTKTMFIGYYKNEELTKNALD-EEGWLHTNDIVEEL 611
                  *************88.44...3.........23589*************98888999*************************9.657*********65 PP

                  TTSEEEEEEECCCEEEET CS
  AMP-binding 406 edGyleivgRkkdliklr 423
                     +++i++R+k+++kl+
   EFC36415.1 612 GPRHIRIIDRLKNIFKLS 629
                  4459************85 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.8   0.0   4.2e-57   1.3e-53       1     257 []     904    1177 ..     904    1177 .. 0.88

  Alignments for each domain:
  == domain 1  score: 181.8 bits;  conditional E-value: 4.2e-57
                     EE-TTSHHHHHHHHHHH....HHS-.TEEEEEE-SSSHH.HHHHHHHHHT-SS-HHHHHHHHHTTTEEEEE--TTSGGGG--HHHHHHHHHH-- CS
  NAD_binding_4    1 lTGaTGFLGkvLlekLL....rttpevkiyllvRaksge.saeeRleeelekkelfsallkelaerikvveGDlseprlGLseedlqelaeevd 89  
                     lTG+TGFLG+++l++LL    + +++vk+y+ vR+k+ + ++  R++e+l +++l+++ +   ++ri+vv+G+l +++lGL ee++++lae++d
     EFC36415.1  904 LTGSTGFLGAFILRDLLealeKAEENVKVYCIVREKNHQdDVFMRVKENLVEFKLWNDKY---EKRISVVKGNLGDDNLGLTEEEFKKLAENID 994 
                     8****************6554455667*******77755389*****************8...******************************* PP

                     EEEE--SS-S.STTSSEEHHHHHHHHHHHHHHHT.........SSS--.-EEEEEE.GGGTTS-TTT--SSS-H.................... CS
  NAD_binding_4   90 viihsaAtvnfdepykellrvNveGtrevlelak.........klkklkvllhvST.ayvngeregeveekvyeege..............kee 159 
                     +i+h++A vn + +y++l++ N+ +t  +l+la          + + l ++++vST ++++   +  +   +                   +++
     EFC36415.1  995 IIYHNGAYVNSVMSYPQLFSSNTGSTLSLLKLAClssklniqsGDSTLAPIVFVSTvGVLQSGLS-LFGIPTS---TsgisnkkditdlinNHM 1084
                     **********************************777776665344448*******877766555.4422222...123577899999998888 PP

                     HHH--EEEETTTCCCHHHHHHHHHHHHHHHHHHHH---EEEEEE-EEE--SSST---TTSHHHHHHHHHHHH-EEES-SB---TT--EEEHHHH CS
  NAD_binding_4  160 kldederaklkglpntYeqsKalaEklvrearrrsglpvvivRpsiitgesktGwingsdlgirgllgliakgvlpeilgdkeavldlvpvDyv 253 
                          +++   + +n+Y+ +K++aE+ +++ar   g+p +i+Rp++i +++++G++n  d++ r+++g+++++ +p+++ +    l++vpvD++
     EFC36415.1 1085 DQVMRQLKPIIERANGYSSTKFVAEQYIQQARLL-GYPGAIFRPGMIGSDTVNGVSNLIDWVNRLVMGCFEMNCFPKTNRT----LNIVPVDII 1173
                     88888888999999******************87.*****************************************88888....9******** PP

                     HHHH CS
  NAD_binding_4  254 anai 257 
                     +++i
     EFC36415.1 1174 SRVI 1177
                     9986 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   4.5e-06     0.013       1     157 [.     902    1116 ..     902    1143 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 4.5e-06
                  EEEETTTSHHHHHHHHHHHHCT......SEEEEEES-STTTTCHHCHHC......................EEEE--TT-HH..HHHHHHHHH..T- CS
   Epimerase    1 ilVtGatGfiGsalvkallekg......yevigldrlssasntarledl......................elveldltdrs..alerlfkee..qp 65  
                  il+tG tGf+G+ +++ lle+       ++v ++ r+++ +      d+                      ++v+++l d++   +e+ fk+   ++
  EFC36415.1  902 ILLTGSTGFLGAFILRDLLEALekaeenVKVYCIVREKNHQD-----DVfmrvkenlvefklwndkyekriSVVKGNLGDDNlgLTEEEFKKLaeNI 993 
                  89***********99999876555556678888888844443.....3344556899***********************9988566666654459* PP

                  SEEEE--S.---HHHHHHSHHHHHHHHTHHHHHHHHHHH..........HHTCTEEEEEEEGGGGT.........................SCSSSS CS
   Epimerase   66 davihlAa.vggvaassedpadfieknlqgtlnlleaar..........kagvkrllflsSsevYG.........................kdaeqp 126 
                  d+++h +a v +v+    +p+  + +n+  tl ll+ a           ++ +  ++f+s++ v                           +     
  EFC36415.1  994 DIIYHNGAyVNSVMS---YPQL-FSSNTGSTLSLLKLAClssklniqsgDSTLAPIVFVSTVGVLQsglslfgiptstsgisnkkditdliN----N 1082
                  ******775666655...7766.668*********998867755555553344477777777666555666666666666665544333321....1 PP

                  ..BSTCSTTS--.--SSHHHHHHHHHHHHHHHHH CS
   Epimerase  127 ..keettltgpl.kpnspYaaaKlageklveaya 157 
                    ++ + + +p+ +  + Y+ +K  +e+++++++
  EFC36415.1 1083 hmDQVMRQLKPIiERANGYSSTKFVAEQYIQQAR 1116
                  2233333445556777777777777777777654 PP

>> Synaptonemal_3  Synaptonemal complex central element protein 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2     7e-05      0.21       5      45 ..     686     727 ..     684     729 .. 0.89
   2 ?   -1.3   0.1      0.65   1.9e+03      20      76 ..     918     973 ..     915     984 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 7e-05
  Synaptonemal_3   5 sseerqyedfskeslqlnkdlek.lteqmedvsvkltwmayd 45 
                     ss+e++  d  k +l+ n+++ k l e++e+vsv+ + + y+
      EFC36415.1 686 SSSEELLSDSEKDLLKTNEKVKKvLCEEIEKVSVNCSLLPYE 727
                     68899999**************9446***********99997 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.65
  Synaptonemal_3  20 qlnkdleklteqmedvsvkltwmaydmvvlrtnPdlaeslrrledeflkCkavlcsl 76 
                     +l + lek  e++    +       d v +r + +l e ++  +d++ k  +v+ + 
      EFC36415.1 918 DLLEALEKAEENVKVYCIVREKNHQDDVFMRVKENLVE-FKLWNDKYEKRISVVKGN 973
                     45556666666666666666666778899999999987.788888888877776655 PP

>> PP-binding  Phosphopantetheine attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0    0.0001       0.3      29      62 ..     806     841 ..     806     846 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.0001
  PP-binding  29 lDSllavellaaleeefgveiplsdlf.e.hptlae 62 
                 +DSl av++ + +++++++++pls +f +  +++ +
  EFC36415.1 806 IDSLHAVKFSGIMKQKYNIDVPLSLIFsQtDRNVDS 841
                 7***********************998444666655 PP

>> N-SET  COMPASS (Complex proteins associated with Set1p) component N
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.3      0.88   2.6e+03      29      68 ..      48      86 ..      39     103 .. 0.56
   2 ?    5.1   0.0    0.0076        23      59      91 ..     777     809 ..     737     812 .. 0.72
   3 ?    4.9   0.0    0.0085        25       2      59 ..    1198    1251 ..    1197    1273 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.88
       N-SET 29 ldekeassdig.nlelwawkqkeikeln...glegikekeekie 68
                ++++++ +d+  +   w+w + +++++n   +     +++   e
  EFC36415.1 48 TNTNDKGTDLCeKCYDWCWDKCKKRRKNaspN-----HQQVDNE 86
                55556666665466668887777777773431.....2222211 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0076
       N-SET  59 gikekeekiegyylenatGcarteGykkIpdke 91 
                 + k +e  i +  l+++tG+a ++G  kI d++
  EFC36415.1 777 KRKLDEDLIRELLLNSQTGSAESDGNMKIIDSL 809
                 223344556689999**************9985 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.0085
       N-SET    2 illdldglqelikDeeDlkflkkllkeldekeassdignlelwawkqkeikelngleg 59  
                  ++++l +l++++ + +Dl  +  + + ++   ++++++n+++  wkq  +++++  ++
  EFC36415.1 1198 FIFELANLDKFVIHIDDLLSIAATTEAKL--LKKEPMQNVTYQKWKQILNERNT--KE 1251
                  6789999***********99999999977..67889999*******99888877..22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1324 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1141  (0.0636399); expected 358.6 (0.02)
Passed bias filter:                      620  (0.0345808); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.05u 0.37s 00:00:01.42 Elapsed: 00:00:00.56
# Mc/sec: 7079.29
//
Query:       EFC36416.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-30  104.1  18.9    5.1e-16   58.8  10.0    3.0  3  CRCB      CrcB-like protein, Camphor Resistance (CrcB)


Domain annotation for each model (and alignments):
>> CRCB  CrcB-like protein, Camphor Resistance (CrcB)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.6   0.2     1e-17   1.8e-13       2      91 ..      25     234 ..      24     238 .. 0.78
   2 ?   -2.4   0.1      0.34   6.1e+03      77      91 ..     347     362 ..     327     366 .. 0.50
   3 !   58.8  10.0   2.9e-20   5.1e-16       3      91 ..     380     490 ..     378     499 .. 0.78

  Alignments for each domain:
  == domain 1  score: 50.6 bits;  conditional E-value: 1e-17
                 HHHHHHHHHHHHHHHH.HHHHBE................................BHHHHHHHHHHHHHHHHHHH.........H.............. CS
        CRCB   2 lvalggalGallRyllssllnkr................................plgtlavNvlGsfllgllla.........l.............. 45 
                 +++++ ++G+l+R+lls++l k                                 +++ l +N++G+f++g+l+          l              
  EFC36416.1  25 YLIVFCMIGVLIRILLSDTLYKPslsssnnnsnnnnimnpstssngnivqsiddlFFSDLYANIVGCFIMGVLMVihlhfikkpLeelkekekallvel 123
                 5789************999988899999999999998887777666666665555346688***********999776665555055555666666677 PP

                 .................................................................HTTTHHHHHS-SHHHHHHHHHHHHHT-HHHHHHH CS
        CRCB  46 .................................................................lttGflGglTTfStfvlelvslleegellaally 79 
                                                                                  l+tG++G++TTfS++ ++++  l +g++l+++  
  EFC36416.1 124 eknkvtnnnnngsssesntpimvksnnssaislegmeeskkrmvklflhrvfhgtlsfekriytgLSTGMCGCITTFSSWQVNAAISLMKGDVLSFVSK 222
                 77777777778888888888888888888888999999999999999999999999999999999***************9999888888877777755 PP

                 HHHHHHHHHHHH CS
        CRCB  80 vllsvvlgllav 91 
                  ++ + ++++a+
  EFC36416.1 223 QVVGFTTCYFAF 234
                 555555555444 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.34
                 H.HHHHHHHHHHHHHH CS
        CRCB  77 l.lyvllsvvlgllav 91 
                 + l v+l  v+++++v
  EFC36416.1 347 VdLFVVLMAVISVFIV 362
                 1344444444444444 PP

  == domain 3  score: 58.8 bits;  conditional E-value: 2.9e-20
                 HHHHHHHHHHHHHHH.HHHHBE........BHHHHHHHHHHHHHHHHHHH.................HHTTTHHHHHS-SHHHHHHHHHHHHHT-HHHH CS
        CRCB   3 valggalGallRyllssllnkr........plgtlavNvlGsfllgllla.................llttGflGglTTfStfvlelvslleegellaa 76 
                  +l+++lG+llRyl+ +l ++         p+ tlavN++Gs++l +l +                 ++++Gf+G+lTT+Stf+ e++ l    ++++ 
  EFC36416.1 380 TLLVAPLGCLLRYLICKLNITFkaverfqmPIFTLAVNIIGSLILVILQGtayvsgftsgvavywidAFSVGFCGSLTTVSTFIQEVYGLN---HTFKK 475
                 6899***********766555599*****989*************99777666677666666666666*********************94...45666 PP

                 HHHHHHHHHHHHHHH CS
        CRCB  77 llyvllsvvlgllav 91 
                  ly l s++++ l+v
  EFC36416.1 476 YLYSLSSIFWTTLVV 490
                 677777766665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1414  (0.0788666); expected 358.6 (0.02)
Passed bias filter:                      520  (0.0290033); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2743.50
//
Query:       EFC36417.1  [L=452]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (452 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 2732.97
//
Query:       EFC36418.1  [L=462]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (462 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       404  (0.0225333); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.25s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 3090.27
//
Query:       EFC36419.1  [L=178]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      3e-24   85.4   0.4    2.4e-17   63.0   0.1    2.2  2  Ribonuc_L-PSP  Endoribonuclease L-PSP


Domain annotation for each model (and alignments):
>> Ribonuc_L-PSP  Endoribonuclease L-PSP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   1.5e-08   0.00027       2      30 ..      89     117 ..      88     121 .. 0.91
   2 !   63.0   0.1   1.4e-21   2.4e-17      65     120 ..     121     175 ..     119     176 .. 0.97

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.5e-08
                    TTSTTTSSS-BSEEEETTEEEEEEE-SB- CS
  Ribonuc_L-PSP   2 eaapaaaapYsqavkagnlvyvsGqlpld 30 
                    ++ap a++pYsq+vka++  y+sG l++d
     EFC36419.1  89 KKAPRAIGPYSQGVKANGNFYISGCLGID 117
                    689************************98 PP

  == domain 2  score: 63.0 bits;  conditional E-value: 1.4e-21
                    GEEEEEEEESSGGGHHHHHHHHHHHSSSSTS--EEEEEE-SBSGGG-SEEEEEEEE CS
  Ribonuc_L-PSP  65 dvVkvtvFladiedfaevnevyaeafdelkeaParsaveVaaLpkgakvEIeaiav 120
                    +vVk+tv+l+di+df++vnevy e+f+ + + Par++++++ Lpk+akvEIeaiav
     EFC36419.1 121 NVVKTTVLLTDINDFQAVNEVYSEYFSGD-NKPARVCYAASGLPKKAKVEIEAIAV 175
                    8****************************.69**********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       441  (0.024597); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1158.84
//
Query:       EFC36420.1  [L=534]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.9e-97  325.2   0.4    4.6e-97  324.9   0.4    1.0  1  PhoPQ_related  PhoPQ-activated pathogenicity-related protein
  ------ inclusion threshold ------
        0.1   13.1   0.1       0.23   11.9   0.1    1.5  1  DUF3934        Protein of unknown function (DUF3934)


Domain annotation for each model (and alignments):
>> PhoPQ_related  PhoPQ-activated pathogenicity-related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  324.9   0.4  5.1e-101   4.6e-97       1     366 []      89     463 ..      89     463 .. 0.94

  Alignments for each domain:
  == domain 1  score: 324.9 bits;  conditional E-value: 5.1e-101
  PhoPQ_related   1 lkdyvek.edeelkyeltetkelegvtiyileltSQkWskeklvdps..lwkHkltivvPke.kkleetalllisggsnenvkkkskesesetlae 92 
                    l++++e+ +d++++y+l +t +   +t+y+l++tSQ W + k   +   +w+H + ++vP++ ++ ++++ll++ g+   n++k+++  + + l++
     EFC36420.1  89 LDEFMESyPDNNYSYRLINTMHGLAATTYVLNMTSQVWLSPKDILNGryVWWHFMLVIVPHNlNRDKKEGLLWMIGKR--NTDKTPNLDDLADLTK 182
                    678899999*****************************998877664459************888999********99..444444455558899* PP

  PhoPQ_related  93 iaretkavvaelsdvPnqpltfeddgk..arkEDdlvAytwrkfleeekdetlplllpmtkaavraMdlvqeflkel.klkiekFvvsGaSKRGWt 185
                    ia  t+++v e+ +vPnq + fe d+k  +r ED +vA+twr+f+++++++ + ++lpmt+a  +++d++q+f+k++ + +ie+F+v G+SK+GWt
     EFC36420.1 183 IAVATGTIVTEMMQVPNQAIVFEADPKreERAEDGIVAFTWRHFMNDTSKPYWIAHLPMTRAGQKGLDTIQDFAKKElGHTIEQFTVQGTSKKGWT 278
                    ***********************998756899*******************************************999****************** PP

  PhoPQ_related 186 twltaivDkrvkaivPvvidilnlekqlkhqlkaYGewslaledYvaegidellktpefkkLlkivDplsYlerl.tipkyiinasgDdffvpdst 280
                    twl a+vDkrvk i+P+vi +l+l+k+l +++++  ++++a+++Y+ +gi   l+t+ef++L+ i Dpl Y er+ +i k++i + gD+ff pd +
     EFC36420.1 279 TWLLAAVDKRVKNIIPMVIAVLDLKKNLMETYDSLCKFPEAMDSYMDQGIVTRLNTKEFDALAGILDPLVYTERYaNINKFLIYSMGDEFFWPDLS 374
                    ***************************************************************************9******************** PP

  PhoPQ_related 281 kfyfekLkgekalrivPnssHglsnkevveslvafvklvaagkelPeleweieese...gtiklkvksseapekvklwtatnesarDfR 366
                       + +L gek+l+++Pn++H++  +++++++   + + + g +lP++e++ ++ +    + +l+++++++p+ vklw+atn++arDfR
     EFC36420.1 375 PNGYPHLVGEKRLKYLPNTGHNMEGSDMMDAVLVDYYAHLYGINLPNYEFSSQDVHsvgLQLDLRITNGTRPTVVKLWQATNPNARDFR 463
                    *************************9999887665556699********99988776767899*************************9 PP

>> DUF3934  Protein of unknown function (DUF3934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   2.6e-05      0.23      12      27 ..     270     285 ..     267     293 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.6e-05
     DUF3934  12 rGTGkKGWsRWdasak 27 
                 +GT kKGW  W  +a 
  EFC36420.1 270 QGTSKKGWTTWLLAAV 285
                 9**********87775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (534 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       645  (0.0359752); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 3306.88
//
Query:       EFC36421.1  [L=370]
Description: hypothetical protein NAEGRDRAFT_54418 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-65  221.6   0.0    1.4e-63  214.9   0.0    2.0  1  Actin     Actin
  ------ inclusion threshold ------
      0.015   14.2   0.0      0.068   12.0   0.0    1.9  1  MreB_Mbl  MreB/Mbl protein


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  214.9   0.0   1.6e-67   1.4e-63       5     405 ..       6     368 ..       3     370 .] 0.88

  Alignments for each domain:
  == domain 1  score: 214.9 bits;  conditional E-value: 1.6e-67
       Actin   5 savVlDnGssttraGyagedaPkavipslvgkprgrkveaklyvgdealtkrpelevrspv.edGvvedwdaveelwehvlkeelkvd..peehplllt 100
                 s+ V+D+Gss+++ G +g+d P ++i     k +      + ++ + +l++ +   ++ p+ + G + + ++ e++++ ++ +elk    + ++p++++
  EFC36421.1   6 STAVIDFGSSSIKSGIGGDDLPASIIAKKSTKIQRI----RSKFLSLNLEDID-GDLKFPIeRGGQISNFNDLEAMLQFIISNELKDYlvELTSPIMIV 99 
                 789********************9998888887776....3444444444332.467778967789******************996644566666655 PP

       Actin 101 .epplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtpry 198
                  +++++ + +r k++E++fEk++ p ++l++    s+ a g++tglv+ sG++ t  +p  dG+ +++   ++++gG++Lte++ +l+++  +     +
  EFC36421.1 100 yNSVTTVKRNRVKIAEMLFEKLQSPIICLVDRSLSSLLAIGRTTGLVLKSGDGLTQSAPFCDGQLISQYCYKLEFGGRDLTEYMGKLIHDD-LG----F 193
                 167778899*********************************************************************************5.22....2 PP

       Actin 199 likkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesalee 297
                 +i+                       k++  e+  +eiKe++ce+s d    e++  +  +k+Y   D+ +i+lg e fk+pEiLF+psli++ ++   
  EFC36421.1 194 TID-----------------------KASGIEHHFKEIKEKLCEISMDYP-LENQRIDICKKVYQVGDQ-TITLGLEQFKCPEILFRPSLINKPEQ--- 264
                 222.......................34566777899***********99.899999*********995.79******************998776... PP

       Actin 298 ekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgv..kvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEY 394
                       +i+eli +++n++++  +++ l n +++GGn+l+p+++eRl +el+   s+++  k ++i+p+ er ys+WiGGSiL++l+++ ++ + k+E+
  EFC36421.1 265 -----PSIHELILKSVNNLEPIFKRDCLDNMILSGGNTLIPNFSERLVQELNSSQSSDYkyKFRVISPP-EREYSSWIGGSILSCLHHVDNISIKKSEF 357
                 .....69*********************************************986665545899*****.***************************** PP

       Actin 395 eEqGssvverk 405
                 eE G+s+v+rk
  EFC36421.1 358 EEIGESIVHRK 368
                 **********9 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   7.5e-06     0.068      64     298 ..      63     311 ..      58     315 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 7.5e-06
                 ETTEESSHHHHHHHHHHHHHHHHTSS-SS--EEEEEE-SS--HHHHHHHHHHH...HHTT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-EEE CS
    MreB_Mbl  64 kdGviadlevaeellkyfikkvkkkkslskprvvicvPsgiteverrAvkeaa...kkaGarevllieeplaAAiGaglpveepsgnmvvdiGggttev 159
                 + G i++++  e++l+ +i++  k+  ++ ++ ++ v +++t v+r+ vk a    +k+ +  + l++ +l     + l + +++g +v+  G g t+ 
  EFC36421.1  63 RGGQISNFNDLEAMLQFIISNELKDYLVELTSPIMIVYNSVTTVKRNRVKIAEmlfEKLQSPIICLVDRSLS----SLLAIGRTTG-LVLKSGDGLTQS 156
                 5799****************9999888877777777788999999998865431115566666677777654....4556666666.8999******** PP

                 EEEETTEEEEEE..EES-SHHHHHHHHHHHHHHHHSEE--.....HHHHHHHHHHH-BSS--...HHHH.....EEEEEEEETTTTCEEEEEEEHHHHH CS
    MreB_Mbl 160 avislggivtsk..svrvaGdeldeaiikyirkkynlliG.....ertaekikieigsavke...eeee.....kmeikGrdlvtglpkevevsseevr 243
                 a    g+++++    +  +G +l e + k+i+ +   +i      e+  ++ik ++ ++ ++   e+++     k+   G + +t    +++  +   r
  EFC36421.1 157 APFCDGQLISQYcyKLEFGGRDLTEYMGKLIHDDLGFTIDkasgiEHHFKEIKEKLCEISMDyplENQRidickKVYQVGDQTITLGLEQFKCPEILFR 255
                 *******997651167789***************99999722222345678887665555441104444333333323344444433344445555555 PP

                 HHHHHH..HHHHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHS CS
    MreB_Mbl 244 ealkep..vsaiveavkevLektppeLaadivdrgivltGGgallkgldkllseetg 298
                  +l ++    +i e + +  ++  p    d +d+ ++l+GG +l+ ++ + l +e++
  EFC36421.1 256 PSLINKpeQPSIHELILKSVNNLEPIFKRDCLDN-MILSGGNTLIPNFSERLVQELN 311
                 55544311447999999999999*********98.5689**********99999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.55
# Mc/sec: 2041.05
//
Query:       EFC36422.1  [L=435]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-11   43.1   6.6    4.5e-11   43.1   6.6    3.6  4  RGS             Regulator of G protein signaling domain
    1.2e-05   25.2   0.1    3.4e-05   23.8   0.0    1.8  2  AhpC-TSA        AhpC/TSA family
     0.0027   17.4   0.0      0.012   15.3   0.0    2.0  2  Redoxin         Redoxin
  ------ inclusion threshold ------
       0.57    9.8   7.7        0.9    9.1   7.7    1.3  1  SR-25           Nuclear RNA-splicing-associated protein
       0.85    9.4   6.4       0.19   11.5   1.7    2.3  2  Acetyltransf_2  N-acetyltransferase


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.22     8e+02      55      78 ..      15      38 ..      11      46 .. 0.86
   2 ?    1.1   0.0      0.12   4.5e+02       2      39 ..      44      82 ..      43     117 .. 0.70
   3 ?   -0.3   0.1      0.35   1.3e+03      86     103 ..     250     267 ..     223     294 .. 0.60
   4 !   43.1   6.6   1.2e-14   4.5e-11       1     118 []     311     433 ..     311     433 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.22
                HHHTSTTSTTSSTS-HHHHHHHHH CS
         RGS 55 neylapsspkelnidkklreelek 78
                ++yl+++s+  ++++k+++++ ++
  EFC36422.1 15 DNYLNSHSKADIFVEKQIFTQFKT 38
                789999999*****9999998776 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.12
                HHHHHTSHHHHHHHHHHHHHTTCT.HHHHHHHHHHHHHT CS
         RGS  2 leslledqpgrslFreFlesefse.enlsFwlaveefkk 39
                l +l +++  + +Fr Fl+   +   n ++++  + +k+
  EFC36422.1 44 LAQLSQHHNCLLIFRRFLRFGGCAfCNRRLYQIAKIYKS 82
                5677788889999*****998887666666665555555 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.35
                 TTTTTHHHHHHHHHHHHH CS
         RGS  86 srklfeeaqeevfellek 103
                 ++  fe++ +e ++ le 
  EFC36422.1 250 KKASFEMLSNEMYKRLEA 267
                 333444444444443333 PP

  == domain 4  score: 43.1 bits;  conditional E-value: 1.2e-14
                 -HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHH.HHHHHHHHTST.TSTTSSTS-HHHHHHHHHHHCSS...STTTTTTHHHH CS
         RGS   1 sleslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkk.akeIyneylap.sspkelnidkklreelekrleke...qpsrklfeeaq 94 
                 s++++l+d++ r++F+ +  +e + en+ F++ v +fk++k++ ++k + ak+++  yl++ + p+ +n +++ r e++k le +   ++ +++f+e+ 
  EFC36422.1 311 SVHDVLQDETKRKYFKVYAFKELNAENITFYETVHQFKQSKDSLDVKFQfAKKVFADYLSNiDNPNFINTNDAKRVEIKKALESNpnsENISSIFDEVL 409
                 5799************************************8888888667*********874667999***************9988889999****** PP

                 HHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS  95 eevfellekdsypkFlkselylrl 118
                 +ev+++   d y +F  s+ ++++
  EFC36422.1 410 NEVMSTVIPDIYMRFKVSKEFEQM 433
                 *******************99986 PP

>> AhpC-TSA  AhpC/TSA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.0   9.4e-09   3.4e-05      18     118 ..      45     154 ..      30     190 .. 0.77
   2 ?   -3.0   0.0       1.8   6.3e+03      76      91 ..     246     261 ..     238     287 .. 0.63

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 9.4e-09
                 EECHHHTTSEEEEE..EESTST-CCHHHHHHHHHHCHHHCCCTTEEEEEEESSSCHHHHHHHHH-H.......SSEEEE-TTSHHHHHTT-EETT..TT CS
    AhpC-TSA  18 vslsdykgkpvvlf..fypkdwcpvCttelpalaklyeefkergvevigvsvdspeshkkfiekes......lnfpllsDeegkvakaygvlkee..kg 106
                  +ls+  +  ++ f  f ++  c +C++ l ++ak y+ + ++++  + + v+s e++k+  e++        ++  l+D+e+ +ak +gv ++     
  EFC36422.1  45 AQLSQHHNCLLI-FrrFLRFGGCAFCNRRLYQIAKIYKSLLQLNIIPVVIHVESDEEVKEILEEHHnsnpilKEMIRLCDKEHLLAKHFGVEFKHpdVP 142
                 344444442333.223688899********************************************999987788889**************9987745 PP

                 ECSCEEEEE-TT CS
    AhpC-TSA 107 lalratfvidke 118
                   l++  vi k+
  EFC36422.1 143 QVLPKLAVIEKD 154
                 555555555554 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.8
                 HHHH-H.SSEEEE-TT CS
    AhpC-TSA  76 fiekeslnfpllsDee 91 
                 +++k++  f++ls e 
  EFC36422.1 246 TKKKKKASFEMLSNEM 261
                 5666667777777643 PP

>> Redoxin  Redoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   3.5e-06     0.012      38     124 ..      64     154 ..      33     172 .. 0.82
   2 ?   -0.2   0.0       0.2   7.1e+02      95     128 ..     155     189 ..     150     196 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 3.5e-06
                 TTT-HHHHHTHHHHHTHHHHHHCSTTTEEEEEESSSHHHHHHHHH.......TT-TSEEEE-TTSHHHHHTT-TTEEE.GGGEEE-EEEEEEET CS
     Redoxin  38 gafcPtCsaehpyleklaellkekgvdvvavvadndafvkefwgk.......eglkfpvlsDgsaaftkalGlrleedaseglrtpryavided 124
                 g  c  C++ + +++k+++ l + ++  v++ + +d+ vke +++       ++  +++l D ++ ++k++G++++ +   +  +p +avi +d
  EFC36422.1  64 G-GCAFCNRRLYQIAKIYKSLLQLNIIPVVIHVESDEEVKEILEEhhnsnpiLK-EMIRLCDKEHLLAKHFGVEFKHPDVPQ-VLPKLAVIEKD 154
                 4.8999***************************************666554322.4555789**********9988887777.99999999988 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.2
                 SHHHHHTT-TTEEE.GGG.EEE-EEEEEEETTEEE CS
     Redoxin  95 aaftkalGlrleedaseg.lrtpryavidedgkvv 128
                   f + lGl+le+  +e  l  p +++i +  ++ 
  EFC36422.1 155 EGFGQVLGLPLEQFEGESfLVVPKMFLIRDSTVIQ 189
                 5689999*999999888899999999998877664 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   7.7   0.00025       0.9      73     134 ..     218     284 ..     211     323 .. 0.57

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00025
       SR-25  73 ssssssssssssssdd....rkkrgkkkdkkkkkkkkk.....kkkkkekkkakekakaeaaaaealpgps 134
                 s ssssssss+  +d     +   + +  k +kkkk k      ++ + k+ + ++++++++++e++  p+
  EFC36422.1 218 SDSSSSSSSSNLLDDLgnagK---SPQMCKLTKKKK-KasfemLSNEMYKRLEAQNTRKAKKQVEKMMKPK 284
                 223333333333444343322...222222222222.2244444555566655566666677777776665 PP

>> Acetyltransf_2  N-acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.2       0.3   1.1e+03     168     198 ..      14      44 ..       6      52 .. 0.70
   2 ?   11.5   1.7   5.4e-05      0.19     139     220 ..     313     394 ..     256     413 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.3
                     HHHHHHHHSTT-HHHCS-EEEEEETTEEEEE CS
  Acetyltransf_2 168 eandylstspdsvftkkllcslatpdgrltL 198
                       n  +s+s++++f++k + ++  ++   tL
      EFC36422.1  14 TDNYLNSHSKADIFVEKQIFTQFKTSNGKTL 44 
                     456667888889***9988887766655555 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 5.4e-05
                     EEEEEEEETTEEEEEEEEEEEEB-HHHHHHHHHHHHHSTT-HHHCS-EEEEEETTEEEEEETTEEEEEETTSEEEEEEE-SH CS
  Acetyltransf_2 139 ewvlekkkreewvklYsftleprqiedfeeandylstspdsvftkkllcslatpdgrltLvgrtlterekdgaleeiklltd 220
                     + vl+ +++ ++ k+Y f+    + + f e+ + +++s+ds  +k  ++ ++++d   ++ + +++ ++  +++e +k l+ 
      EFC36422.1 313 HDVLQDETKRKYFKVYAFKELNAENITFYETVHQFKQSKDSLDVKFQFAKKVFADYLSNIDNPNFINTNDAKRVEIKKALES 394
                     568999999***********************************************************44444444444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (435 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1439  (0.080261); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 2680.28
//
Query:       EFC36423.1  [L=329]
Description: hypothetical protein NAEGRDRAFT_54420 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      0.002   17.9   0.2     0.0044   16.9   0.2    1.6  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.011   15.3   2.1      0.019   14.5   2.1    1.3  1  Stevor      Subtelomeric Variable Open Reading frame
       0.12   12.3   0.2       0.23   11.4   0.2    1.4  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.2   7.3e-07    0.0044       8      38 ..      96     126 ..      90     134 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 7.3e-07
                 HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHT CS
       F-box   8 sevlrhILerLplsdllalrrVSkgwrilid 38 
                 s+++ ++L++L+  d++ +   +k+w+++i 
  EFC36423.1  96 SDIMWNVLQFLEVDDICEMLIICKRWKQIIL 126
                 489*************************995 PP

>> Stevor  Subtelomeric Variable Open Reading frame
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   2.1   3.2e-06     0.019      37     123 ..      23     113 ..      20     139 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 3.2e-06
      Stevor  37 KeiidklNeeaikkYqqthdpykqLkevveKngtkstggn..daepmStiEkeLletYeevfgde..sdimlksgmytnddekssdsksce 123
                 K i  klN     k ++ h+  +qL+++ eK ++k ++++  d e + +  k+++  Ye+   +   +++m  s++  n  +  + +  ce
  EFC36423.1  23 KGIKYKLNTAIDWKTRKIHQQIEQLEQIQEKSKKKRKNRHdhDREIIEKPSKKIVPLYEDASCESewKKLMDLSDIMWNVLQFLEVDDICE 113
                 667778998877899***************9888776665116678899999*******98865422678888998888766555555555 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2   3.8e-05      0.23       7      38 ..      97     128 ..      96     130 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3.8e-05
  F-box-like   7 EiLlqIFsyLppsdLlrlalVCrrWrrvaldt 38 
                 +i+  ++++L+  d++     C+rW++++l +
  EFC36423.1  97 DIMWNVLQFLEVDDICEMLIICKRWKQIILEE 128
                 688999**********************9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2099  (0.117073); expected 358.6 (0.02)
Passed bias filter:                      874  (0.0487478); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.35s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 1970.63
//
Query:       EFC36424.1  [L=279]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-42  144.3   0.1    9.9e-39  133.6   0.1    2.0  1  Palm_thioest   Palmitoyl protein thioesterase
    6.2e-05   22.4   0.0    9.4e-05   21.8   0.0    1.3  1  Hydrolase_4    Serine aminopeptidase, S33
    6.6e-05   22.7   0.0    0.00014   21.6   0.0    1.5  1  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.014   14.7   0.0      0.076   12.3   0.0    2.0  3  DUF915         Alpha/beta hydrolase of unknown function (DUF9
       0.18   11.3   0.0       0.23   10.9   0.0    1.3  1  DUF900         Alpha/beta hydrolase of unknown function (DUF9


Domain annotation for each model (and alignments):
>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.6   0.1   2.8e-42   9.9e-39       1     242 []      30     260 ..      30     260 .. 0.78

  Alignments for each domain:
  == domain 1  score: 133.6 bits;  conditional E-value: 2.8e-42
  Palm_thioest   1 PvviwhGldsaesn..mqklaeliekli..gtyvknveigeseaedrkasffgnlndqvea......vckklelangfhaiGfSQGglflRalierc 87 
                   P++++hG+   ++n  ++ l+++i++++  gt v+++      +e   +s+++++ +q+e+      ++kk+   +  h+i++SQGgl++R +++++
    EFC36424.1  30 PILLMHGI--LCGNntLKALRDMIKERVppGTIVYSIP-----SEGMVSSVLTPVSAQLEDfrkqinIVKKNFGITDHHLICHSQGGLICRSYLQTT 119
                   99******..444447**********99966******9.....566789999********955555544443345678******************* PP

  Palm_thioest  88 ddkknvrnlislggpqaGvfglllckvaekllasgavysklvqkslvqaqywrdpekleeYlkknkFLpdiNnerdhaknetykknllkleklvlvg 184
                   +d++ v+ +isl+g+q+G +g++           g+ ++ + ++  ++  +++   + + Y+   +  +d++      +  +y++n+l+++k+vl g
    EFC36424.1 120 PDHN-VKVFISLSGVQNGEYGVP----------VGFQFEGFLKQ--MFPFLFNTALE-DVYKIFYT-AKDVDYA----RTLNYRENMLRIDKMVLTG 197
                   8776.****************93..........22234444444..23334444443.44443333.2334444....4558*************** PP

  Palm_thioest 185 fsdDtvvvPkeSslfgfykeks....eevpleetelYkedllGLrtLdergrlellevpg.eH 242
                   +++D+++vP +S+lf+fy+ +s    + +p+e++++Y++d++GL+tL+e++rl  ++vp+  H
    EFC36424.1 198 SPQDDIIVPYQSALFEFYQVNStgglDMIPMEQQRIYQNDVFGLKTLNEENRLVRIVVPNvYH 260
                   *******************9888884436***************************9998666 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.0   2.6e-08   9.4e-05      54     109 ..      76     132 ..      66     192 .. 0.81

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 2.6e-08
  Hydrolase_4  54 sfddyvdDlaafvekvkeehpelplfllGhSmGGliallyllrypd.kvaglilsaP 109
                  +++  ++D+++ ++ vk++ + + + l++hS GGli  +yl++ pd +v+ +i  + 
   EFC36424.1  76 PVSAQLEDFRKQINIVKKNFGITDHHLICHSQGGLICRSYLQTTPDhNVKVFISLSG 132
                  667789***********************************9999934445554444 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.0     4e-08   0.00014      55     107 ..      80     137 ..      56     200 .. 0.74

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 4e-08
                    SHHHHHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHHH.GGGEEEEEEESE....C CS
  Abhydrolase_1  55 gtasvaddldrildalgddkltlvGhSmGGmialayaaey.perVkalvllga....i 107
                    ++ ++++ ++ ++  +g+   +l+ hS+GG+i++ y++   +++Vk +++l++     
     EFC36424.1  80 QLEDFRKQINIVKKNFGITDHHLICHSQGGLICRSYLQTTpDHNVKVFISLSGvqngE 137
                    567899999999****************************8899******99944431 PP

>> DUF915  Alpha/beta hydrolase of unknown function (DUF915)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.24   8.6e+02       8      55 ..      25      70 ..      21      73 .. 0.66
   2 ?   12.3   0.0   2.1e-05     0.076      91     128 ..      86     123 ..      75     141 .. 0.80
   3 ?   -3.4   0.0       1.3   4.7e+03     132     205 ..     189     206 ..     176     235 .. 0.56

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.24
      DUF915  8 kkkeiPtifihGyggtaeslnemvkqlenkegkkkkvltvdvskdgev 55
                +k   P++++hG    +++l+ + + +  ke +    +++++ ++g v
  EFC36424.1 25 NKPFLPILLMHGILCGNNTLKALRDMI--KERVPPGTIVYSIPSEGMV 70
                566678888888888888877766666..3555555566666665555 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.1e-05
      DUF915  91 kvlseLkkkYnikkfnavGhSmGglaltsYleeyaddk 128
                 k ++  kk+++i+   ++ hS Ggl + sYl+++ d +
  EFC36424.1  86 KQINIVKKNFGITDHHLICHSQGGLICRSYLQTTPDHN 123
                 5567789************************9987765 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 1.3
      DUF915 132 qlkklvtiggpfngienndedetlaqvkkdgpkkktqaykkllknqkkkipkdlevlniaGdledgkqsDgivp 205
                  ++k+v  g+p ++i +                                                        p
  EFC36424.1 189 RIDKMVLTGSPQDDIIV--------------------------------------------------------P 206
                 56666666666555532........................................................2 PP

>> DUF900  Alpha/beta hydrolase of unknown function (DUF900)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   6.4e-05      0.23      77     119 ..      81     123 ..      47     204 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 6.4e-05
      DUF900  77 rdalekllrylatkksakkihllaHSmGtwlvlealrqlaiea 119
                  +++ k +++++++ +  + hl++HS G  + ++ l+    ++
  EFC36424.1  81 LEDFRKQINIVKKNFGITDHHLICHSQGGLICRSYLQTTPDHN 123
                 578999*************************999999765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       362  (0.0201908); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1682.32
//
Query:       EFC36425.1  [L=546]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.1e-19   68.2  27.7    1.5e-18   66.9  27.8    1.6  2  MFS_1       Major Facilitator Superfamily
  ------ inclusion threshold ------
       0.45    9.3  17.9     0.0063   15.4   3.3    2.5  2  MFS_1_like  MFS_1 like family


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.9  27.8   1.7e-22   1.5e-18      10     329 ..      81     439 ..      72     463 .. 0.68
   2 ?   -3.7   0.0      0.49   4.4e+03     150     171 ..     488     509 ..     480     529 .. 0.58

  Alignments for each domain:
  == domain 1  score: 66.9 bits;  conditional E-value: 1.7e-22
       MFS_1  10 larsilgpalpl.alaedlgispseigllltlyalgaavaslplGrlsdrfGrrrvlllglllfalglllllfa..ss....lwlllvlrvlqGlgaga 101
                 ++ ++++++l + +   +       i++++ +y ++++ ++ + ++++ ++G r  +l++ +l ++g+++ +++   +    +w+ +++ +l+++++ +
  EFC36425.1  81 FSNFFTIALLYWnMPDATWK-----INMMTLIYLIFYVPMTSISSYVMKKHGLRTSILIASILNFVGGWVRCLGykKGeelfFWVAFLGQALCAIAQPL 174
                 33333333333222233333.....7779999***********************6666666666665877754432256656699999********** PP

       MFS_1 102 lfpagaaliadwfpkeergraigllsagfslGailgpllggllasslg.......Wrav.......fyilaivsllafvlfllllpeepperkrkspke 186
                 +  a   l++ wf ++er+ a+ + +++  lG+  + ++g++l+ +         W+++           a+++ +++ + ++++ ++pp+++ +   e
  EFC36425.1 175 ISNAPTLLASNWFGEKERTIATTIGTLMGILGSGAAFGFGPFLLGLTEdsqsgeyWTGSeygmlimLGGQAALATILMTCSVAFFKDKPPTPPYFQAPE 273
                 ********************************************666699*****88884443222333333333334477788888888777776666 PP

       MFS_1 187 ee....................kgtgpaplvp........awkallkdpvlwillialllfffgfsglltllplylqevlglsglllaglllallalvg 257
                 e                              p         +k++l++  ++il +a  ++  +++++++l+  +     g++  + ++++   + ++g
  EFC36425.1 274 EAlreptsinenpiegetseaiI--------PvvqhsffqDLKQVLTNCNFLILAAAYSVGYSVLQSFVALIDQI-IVPKGYT-PYDGSIFGITVIFFG 362
                 65677777777777555666662........2444444446********99756666666666777788888886.*******.566666666666666 PP

       MFS_1 258 ailallagrlsdrlgrrrrlllallllllaalglallavt....ssavllllvlvliGf...glgfvfpsllalasdla 329
                 +i+a ++g ++dr+++  + lla ++++la+lg+a +av     ++++l++++++++ +   ++  ++p+ l +  +++
  EFC36425.1 363 IIGATVVGVVADRTKK--YKLLAASCGFLATLGFAGFAVVmlwkKTTLLFYMACLCLAIlgmFSVPTVPLCLEMGCEVT 439
                 66699********888..6666666666666666666666667877777777777766620044444555555555555 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 0.49
       MFS_1 150 Wravfyilaivsllafvlflll 171
                  + + +i   +++l+f+l  ++
  EFC36425.1 488 IQIILWIDLSLLCLSFILTSIF 509
                 4555555555555555542222 PP

>> MFS_1_like  MFS_1 like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   6.9     0.062   5.5e+02     246     369 ..      83     217 ..      72     229 .. 0.66
   2 ?   15.4   3.3     7e-07    0.0063       3      85 ..     318     400 ..     316     509 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.062
  MFS_1_like 246 nFlflYLkelgasntllG..slvalgvvaeiplfffaeklleklGhvk.lliiallayi...lrfllyaii..enawlvlpievLhgisfgllwaaave 336
                 nF+++ L   + +  ++   +++ +  +  +p+  +++++++k G+++ +li+++l ++   +r l+y       +w++++ ++L +i+  l+  a + 
  EFC36425.1  83 NFFTIALLYWNMPDATWKinMMTLIYLIFYVPMTSISSYVMKKHGLRTsILIASILNFVggwVRCLGYKKGeeLFFWVAFLGQALCAIAQPLISNAPTL 181
                 55555555555555555410444566677888888999999****9752666777777623356667777764557999**************999999 PP

  MFS_1_like 337 yvskiapk..sleatgqg.llsglyfglGralGsli 369
                  +s+ +++  +++at++g l+ +l  g+  ++G ++
  EFC36425.1 182 LASNWFGEkeRTIATTIGtLMGILGSGAAFGFGPFL 217
                 999999862245555555134444455555555555 PP

  == domain 2  score: 15.4 bits;  conditional E-value: 7e-07
  MFS_1_like   3 slkilyFfffaalgsllPYltiylkskglkaseigiitlilpltsilsppiwgvlaDrfgkrkkvvilslllsavlflsllfi 85 
                  l + y + +++l s++  +   +  kg+++++  i    + ++ i+++ ++gv+aDr++k+k +++ + +l+++ f+++ ++
  EFC36425.1 318 ILAAAYSVGYSVLQSFVALIDQIIVPKGYTPYDGSIFGITVIFFGIIGATVVGVVADRTKKYKLLAASCGFLATLGFAGFAVV 400
                 5778899999999999999999999********9999999**********************************999987755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (546 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       729  (0.0406604); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.47
# Mc/sec: 3458.57
//
Query:       EFC36426.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.046   14.5   0.8       0.18   12.6   0.3    2.3  2  GPI-anchored  Ser-Thr-rich glycosyl-phosphatidyl-inositol-anc


Domain annotation for each model (and alignments):
>> GPI-anchored  Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.3     1e-05      0.18      40      87 ..       5      53 ..       1      56 [. 0.78
   2 ?   -1.5   0.0      0.26   4.6e+03      24      32 ..     243     251 ..     204     266 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1e-05
  GPI-anchored 40 nlksvktiasgiknsdgsytwtvpaslesggaYflqiv.sesnegiyny 87
                  + ++ +t a++ +n+++  +w+ p+s + ++++ +++v s+++  ++n 
    EFC36426.1  5 SSNPNTTTATTSSNDKKRRSWKAPSSSNGDDEFKIKLVgSDNQIIVHNS 53
                  4677888888899999**********************55555355554 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.26
  GPI-anchored  24 tdpgtvtlv 32 
                   t ++++t+ 
    EFC36426.1 243 TAQESITVN 251
                   222222322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1644.51
//
Query:       EFC36427.1  [L=732]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-57  194.6   0.1    2.1e-57  194.0   0.1    1.3  1  Peptidase_S9   Prolyl oligopeptidase family
    1.1e-05   25.2   2.6      0.035   13.8   0.0    2.8  3  Abhydrolase_1  alpha/beta hydrolase fold
    0.00041   20.0   0.1       0.26   10.8   0.0    2.5  2  Peptidase_S15  X-Pro dipeptidyl-peptidase (S15 family)
      0.002   18.0   3.9     0.0022   17.9   0.4    2.8  3  PD40           WD40-like Beta Propeller Repeat
  ------ inclusion threshold ------
      0.064   12.8   0.0       0.13   11.7   0.0    1.5  1  DLH            Dienelactone hydrolase family


Domain annotation for each model (and alignments):
>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  194.0   0.1   5.9e-61   2.1e-57       1     210 [.     521     731 ..     521     732 .] 0.96

  Alignments for each domain:
  == domain 1  score: 194.0 bits;  conditional E-value: 5.9e-61
                   ----HHHHHHHCCT-EEEEE--TTSSTTHCHHHHTTSGGGGHHHHHHHHHHHHHHHHTT.S--GGGEEEEEETHHHHHHHHHHH.H-GGG-SEEEEE CS
  Peptidase_S9   1 psfsselqlladrGyvvvvanirGsggyGeafhdagkrklgqnefdDfiaaaealakeg.yvdserlaitGgSyGGyltgaaln.qrpdlFkaavae 95 
                   +s+++++ql+a++Gy+v+++n++Gs+g+G +f++++ +++g++ ++D+ +++++l++++ ++d + +++ G+S+GG+ ++++l+ +++++Fk+ v +
    EFC36427.1 521 WSYRWNPQLFASQGYAVIMINFHGSDGFGLKFKESILGNWGSYPYEDITKGTDFLISTNsFMDGNSMCALGASFGGFSVNWLLGhNENNRFKCFVTH 617
                   799*********************************************************************************999********** PP

                   SE---CCCHHCSTTS..THH.HCCCC--TTTCHHHHHHHHHH-CGGG-----EEEEEEETT-SSS-THHHHHHHHHHH--S-SEEEEEETTS-SSTT CS
  Peptidase_S9  96 vpvvdvlrydsdtdl..lte.eymewgnpeeneegykelspyspldnvkaypplLlihGlaDdrvppaealklvaaLqkkgknvlllifpdegHgvg 189
                   ++ +++++++++td   + e ey++  +p  n e+y++++p++++++  +++p+L+ihG +D r p+a++l++++aLq++g+++++ +fp+e+H+v 
    EFC36427.1 618 DGLSELVSSYYSTDElwFPEaEYQG--TPFTNSEHYQKFNPINHVTK--WKTPTLVIHGGKDFRLPIAQGLTVFTALQRQGVPSKMIVFPEENHWVL 710
                   ******9999999988777766666..5556****************..************************************************ PP

                   SSHHHHHHHHHHHHHHHHHCT CS
  Peptidase_S9 190 kprakveelarllaFlkealg 210
                   kp+++  ++ ++l++l+ +lg
    EFC36427.1 711 KPQNSMLWYDTVLDWLATWLG 731
                   ******************997 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.4   4.9e+03      29      50 ..     286     307 ..     277     329 .. 0.78
   2 !   10.1   0.9   0.00012      0.45       5     106 ..     508     619 ..     508     636 .. 0.78
   3 !   13.8   0.0   9.7e-06     0.035     191     253 ..     643     710 ..     623     712 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.4
                    TSEEEEEEETTSTTSSSTTTGB CS
  Abhydrolase_1  29 gfdvillDlrGvgySspapaci 50 
                    g+ +++ D+ G+   s ++++ 
     EFC36427.1 286 GWKIYVADVYGYNTQSGPISTS 307
                    8999999999999999998874 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00012
                    EE-STTTCG..GGGTTGHHHHHHHHTTSEEEEEEETTS.TTSSSTTTGB....CHHSHHHHHHHHHHH..HHHCTTSSEE.EEEETHHHHHHHHHH CS
  Abhydrolase_1   5 ilhGlpgss..dvwaerglapaLakdgfdvillDlrGv.gySspapacin...ddygtasvaddldri..ldalgddklt.lvGhSmGGmialaya 91 
                    ++hG+p+ss  d+w  r  ++ +a +g+ vi+++  G+ g++ + +++i      y+  ++ +  d++   +++ d++    +G S+GG+ + +++
     EFC36427.1 508 LIHGGPESSftDSWSYRWNPQLFASQGYAVIMINFHGSdGFGLKFKESILgnwGSYPYEDITKGTDFLisTNSFMDGNSMcALGASFGGFSVNWLL 603
                    69*****5422556666667778888*********9983344444444447788899999999999666899999999999*************** PP

                    HHH.GGGEEEEEEESE CS
  Abhydrolase_1  92 aey.perVkalvllga 106
                      + ++r k++v+ ++
     EFC36427.1 604 GHNeNNRFKCFVTHDG 619
                    999*********9998 PP

  == domain 3  score: 13.8 bits;  conditional E-value: 9.7e-06
                    HHHHCCHHHHHHHHHC.THHHHSEEEEEEETTCSSSCH.HHHHHHHHCHTS...EEEEEEETCSSSHH CS
  Abhydrolase_1 191 qwpttdsaklllrlre.lknvlaptlvisgtsDplvpp.kaledlaqllpk...krlvvisdagHlaf 253
                    ++ t+ +++   +  + +++ + ptlvi+g +D   p+ + l  +++l ++   ++ +v++ + H+++
     EFC36427.1 643 TPFTNSEHYQKFNPINhVTKWKTPTLVIHGGKDFRLPIaQGLTVFTALQRQgvpSKMIVFPEENHWVL 710
                    44444444444444446899999*************************6667777***********86 PP

>> Peptidase_S15  X-Pro dipeptidyl-peptidase (S15 family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.0    0.0014       5.2      52     146 ..     521     631 ..     484     648 .. 0.70
   2 !   10.8   0.0   7.3e-05      0.26     212     264 ..     648     703 ..     637     709 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0014
                    H........HHHTT-EEEEEE-TTSTTS-S---TT......TTTHHHHHHHHHHHHHHC.TTEEEE.EEEEEECHHHHHH.HHHCTT--TTEEEEE CS
  Peptidase_S15  52 v........fvarGYavVvqdvrGtggSeGeftvg......dsdeaedgadvidWlakq.pwsnGk.VgmtGiSYlGttq.llaaatgvpalkaiv 130
                             f+++GYav++ +  G+ g  G    +      +s   ed  +  d l  + ++ +G+  +++G S++G+   +l+ +++  + k+ v
     EFC36427.1 521 WsyrwnpqlFASQGYAVIMINFHGSDG-FGLKFKEsilgnwGSYPYEDITKGTDFLISTnSFMDGNsMCALGASFGGFSVnWLLGHNENNRFKCFV 615
                    1444444449********999988643.34333336788887778888888888888877888886589999999999752677788899999999 PP

                    EECE-S-TCCCCSECT CS
  Peptidase_S15 131 peaaisdlyddyyreg 146
                       ++s l+  yy + 
     EFC36427.1 616 THDGLSELVSSYYSTD 631
                    9999999999555444 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 7.3e-05
                    SHHHHTT-HHHHHCT--S-EEEEEECCSSTTC.CHHHHHHHHHCCTT-..EEEEEC CS
  Peptidase_S15 212 dafWkdrnlsedadkvkapvllvgGwnDwnvk.ngaiklyealkapgv..klilgp 264
                    +++ ++ n+ ++++k+k+p+l+++G  D      + + ++ al+++gv  k+i+ p
     EFC36427.1 648 SEHYQKFNPINHVTKWKTPTLVIHGGKDFRLPiAQGLTVFTALQRQGVpsKMIVFP 703
                    456778888999****************988899************9999887754 PP

>> PD40  WD40-like Beta Propeller Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.43   1.6e+03      14      26 ..      53      65 ..      51      66 .. 0.85
   2 !   17.9   0.4     6e-07    0.0022       8      37 ..      96     127 ..      88     128 .. 0.78
   3 ?   -2.9   0.1         2   7.3e+03      13      18 ..     322     327 ..     321     327 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.43
                EEE-TTSSEEEEE CS
        PD40 14 PsfSPDGkrlaFs 26
                 s+S DG++ ++s
  EFC36427.1 53 ASVSVDGRYAVYS 65
                67888******97 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 6e-07
                 SS.EEEEEE-TTSSEEEEEEECT...TCEEEE CS
        PD40   8 pgnegaPsfSPDGkrlaFsSdRg..sGkpdIy 37 
                  +n+++P f+PDG+ + F S+      +p++y
  EFC36427.1  96 GSNDFSPKFTPDGQFILFLSTSRgsANSPQLY 127
                 459*****************966555555577 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 2
                 EEEE-T CS
        PD40  13 aPsfSP 18 
                 +P+fSP
  EFC36427.1 322 NPTFSP 327
                 6****9 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   3.8e-05      0.13     135     192 ..     655     712 ..     638     722 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.8e-05
         DLH 135 keleeaakikapilalfgeeDefipadevekleealkaanvdlelkvYpgagHaFand 192
                 +++++++k k+p l+++g++D   p ++  ++  al+ ++v+ ++ v+p+  H  +++
  EFC36427.1 655 NPINHVTKWKTPTLVIHGGKDFRLPIAQGLTVFTALQRQGVPSKMIVFPEENHWVLKP 712
                 6889999*********************999********************9966555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (732 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       402  (0.0224218); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.50
# Mc/sec: 4419.36
//
Query:       EFC36428.1  [L=470]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.31   12.0   0.0       0.31   12.0   0.0    2.7  3  DUF4834   Domain of unknown function (DUF4834)


Domain annotation for each model (and alignments):
>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.8     0.088   1.6e+03      42      82 ..      21      61 ..       7      73 .. 0.45
   2 ?   12.0   0.0   1.7e-05      0.31      56      99 .]      98     141 ..      81     141 .. 0.80
   3 ?   -2.2   0.2      0.48   8.6e+03      47      68 ..     295     306 ..     283     322 .. 0.35

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.088
     DUF4834 42 aqkqfgnstnsnqqksqsrsetkeegeiieeersekeakrk 82
                 ++++ n ++   +++++++++++  +i ++++ ++++++k
  EFC36428.1 21 ITENSDNDFELGIFSHHQQQQQDKLSTIRSSSSLSTPSHHK 61
                44444444444444444444444444444444444433333 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 1.7e-05
     DUF4834  56 ksqsrsetkeegeiieeersekeakrkkiFekdeGEYVdFEEvk 99 
                 ++q++   ++eg++   ++++++ +rk++ +      VdFEEvk
  EFC36428.1  98 AQQHKVLATKEGSMRRANSNNSKVRRKRVHDIHTPTHVDFEEVK 141
                 445566677789999999999999999****************8 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.48
     DUF4834  47 gnstnsnqqksqsrsetkeege 68 
                 ++          +r++t++  +
  EFC36428.1 295 SS----------ERTKTDNFYN 306
                 11..........2222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (470 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.22s 00:00:00.75 Elapsed: 00:00:00.41
# Mc/sec: 3424.91
//
Query:       EFC36429.1  [L=1010]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.8e-24   82.2   3.9    7.5e-06   25.7   0.0    8.1  9  NHL       NHL repeat
     0.0016   18.0   0.3      0.025   14.2   0.1    3.1  3  SGL       SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.049   13.3   0.0       0.11   12.1   0.0    1.5  1  FNIP_C    Folliculin-interacting protein C-terminus


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   1.1e-05     0.066       2      23 ..      65      86 ..      64      90 .. 0.91
   2 !   20.7   0.0     5e-08    0.0003       1      22 [.     120     141 ..     120     146 .. 0.90
   3 !   25.7   0.0   1.3e-09   7.5e-06       1      28 []     159     186 ..     159     186 .. 0.96
   4 ?   -2.6   0.0       1.2     7e+03      14      27 ..     271     284 ..     264     284 .. 0.74
   5 !    9.0   0.0   0.00026       1.5      12      27 ..     328     343 ..     318     344 .. 0.78
   6 ?   -0.6   0.0      0.27   1.6e+03      11      21 ..     558     568 ..     554     569 .. 0.80
   7 ?   -1.7   0.1       0.6   3.6e+03       8      18 ..     617     626 ..     616     626 .. 0.76
   8 ?   -1.7   0.0       0.6   3.6e+03       8      16 ..     772     780 ..     771     781 .. 0.87
   9 !    5.1   0.0    0.0043        26       5      22 ..     941     959 ..     937     960 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.1e-05
                SSEEEEEEETTTEEEEEECCCT CS
         NHL  2 nyPhGvavdsnGdiyVaDsenh 23
                 +P+G+++ +++d++++Ds +h
  EFC36429.1 65 LSPSGICAGQSDDLFISDSSRH 86
                68*****************999 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 5e-08
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 fn+P+G+a+++nG++y+aDs n
  EFC36429.1 120 FNSPNGIAMSPNGNLYIADSQN 141
                 99*****************977 PP

  == domain 3  score: 25.7 bits;  conditional E-value: 1.3e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f+ P Gvav+ n+ +y+aD++n+ ++++
  EFC36429.1 159 FSKPLGVAVSANNLVYIADTGNNLIKKY 186
                 899**********************987 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 1.2
                 EEEEEECCCTEEEE CS
         NHL  14 diyVaDsenhrvqv 27 
                 +iy + + nh +q+
  EFC36429.1 271 EIYTTSNTNHFIQK 284
                 78888889999986 PP

  == domain 5  score: 9.0 bits;  conditional E-value: 0.00026
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 n  iy+aDs+n+++++
  EFC36429.1 328 NSIIYIADSKNNCIRK 343
                 5569**********86 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.27
                 TTTEEEEEECC CS
         NHL  11 snGdiyVaDse 21 
                 +nG iy +D+ 
  EFC36429.1 558 NNGKIYASDTS 568
                 8********75 PP

  == domain 7  score: -1.7 bits;  conditional E-value: 0.6
                 EEETTTEEEEE CS
         NHL   8 avdsnGdiyVa 18 
                 +v +nGd+y +
  EFC36429.1 617 VV-NNGDLYLT 626
                 55.8***9976 PP

  == domain 8  score: -1.7 bits;  conditional E-value: 0.6
                 EEETTTEEE CS
         NHL   8 avdsnGdiy 16 
                 ++dsnG+iy
  EFC36429.1 772 TIDSNGEIY 780
                 689*****9 PP

  == domain 9  score: 5.1 bits;  conditional E-value: 0.0043
                 EEEEEE.TTTEEEEEECCC CS
         NHL   5 hGvavd.snGdiyVaDsen 22 
                 +G++v+ ++ diyV+D+++
  EFC36429.1 941 RGLVVNeKTSDIYVSDRNS 959
                 69**************985 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.1   4.2e-06     0.025     131     220 ..     118     196 ..     108     199 .. 0.84
   2 ?   -1.4   0.0      0.23   1.4e+03     145     163 ..     328     346 ..     325     351 .. 0.87
   3 ?   -2.2   0.0      0.42   2.5e+03      47      76 ..     773     801 ..     715     847 .. 0.60

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 4.2e-06
         SGL 131 ddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfdpdGklieei 220
                 + ++ pNG+a+sp g+ lY+aDs ++ki  ++    ++        +d++  +  p G+av a++ v++A  g++ + ++dp  k +++i
  EFC36429.1 118 SLFNSPNGIAMSPNGN-LYIADSQNDKIRIVSNGIVSS--------IDGTFSK--PLGVAVSANNLVYIADTGNNLIKKYDPTTKTLTTI 196
                 55789********986.899********9887765555........7777776..99*************************97777665 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.23
         SGL 145 gktlYlaDsltrkiwaydv 163
                 ++ +Y+aDs +++i ++d 
  EFC36429.1 328 NSIIYIADSKNNCIRKVDT 346
                 6789**********99985 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.42
         SGL  47 aprkdgrlvvasksglalldlasgeletla 76 
                 ++  +g++++   ++++ +d +++ +++l+
  EFC36429.1 773 ID-SNGEIYLYTMQDIFKMDKNTRVIRKLF 801
                 33.334444444444444444444444444 PP

>> FNIP_C  Folliculin-interacting protein C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   1.8e-05      0.11     114     156 ..     876     918 ..     832     925 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.8e-05
      FNIP_C 114 mLesvvqlyklklsaefcigilEdkLqelylkSeaLaellrsk 156
                 + +s++ + +  l ++  i i+EdkL  +y+kSea++++++++
  EFC36429.1 876 LQTSFQGISSFFLKSNGDILIMEDKLVRIYVKSEAIVKIIAGT 918
                 55678888887777777799******************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1010 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       613  (0.0341904); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.29s 00:00:01.06 Elapsed: 00:00:00.48
# Mc/sec: 6305.39
//
Query:       EFC36430.1  [L=354]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.1e-34  117.1   0.0    1.2e-33  116.6   0.0    1.2  1  TatD_DNase    TatD related DNase
    0.00099   19.2   0.0      0.017   15.2   0.0    2.4  2  Gemini_AL1_M  Geminivirus rep protein central domain


Domain annotation for each model (and alignments):
>> TatD_DNase  TatD related DNase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  116.6   0.0   1.4e-37   1.2e-33       1     184 [.     104     313 ..     104     326 .. 0.78

  Alignments for each domain:
  == domain 1  score: 116.6 bits;  conditional E-value: 1.4e-37
                 EEEEE-TTS..CCC...........TTT..........HHHHHHHHHHTTEEEEEEE-SSGGGHH...HHHHHHTT.TTTEEEEE---GGGGGCC.CCH CS
  TatD_DNase   1 iDaHcHlds..kef...........eed..........reeileraeeagvaavvvvgtsskdsk...avlelakkypnkvyavlGiHPnevdeasedl 73 
                 +D+H+H++   +++           e +           +++l++   +++  +v+v++++++++    + +l++  + ++ +++G+HP+++   +e++
  EFC36430.1 104 VDTHVHFEYilQRVfnaqlgeisssE-KklinaltfdtTDKELSERILSRMNGFVCVQCDPTSFSslgMWRDLIEMKNLNIGVTFGLHPHNASYYDEKM 201
                 69999999853333333333333221.03333333334444443333344455557777777666566888999999999******************* PP

                 HHHHHHHHHCCCTSEEEEEEEEEET-CCCCCGHHHHHHHHHHHHHHHHHTTEEEEEEEES-HHHHHHHHHHCGGCCSEEEETT--S-HHHHHHHHHT.. CS
  TatD_DNase  74 leelkelanvkhskvvaiGeiGLDyysreestkeaqeevFeeqlrlAkelklplviHlrkaeedlleilkeaaeakakvvlHsfsgsaeeakkflkl.. 170
                  + ++++ + + +k+va Ge+GLDy + ++s+ke+q + F +ql+ A  l+lp+v+H+r+ae+d l+i+k++ +++ k+++H+f+ + e a+k+++   
  EFC36430.1 202 QDRINQCISEAGNKCVAYGECGLDY-HYNNSPKEVQMACFAKQLQNAVALSLPVVVHAREAEDDALQIMKDNLPKDWKIHVHCFTDRLEFAQKLISHfp 299
                 *******888899************.6677******************************************99999******************8889 PP

                 TEEEEE-GGGGTTT CS
  TatD_DNase 171 gyyislsglltfkn 184
                 ++yi+++g++t+  
  EFC36430.1 300 NLYIGFTGVVTYAP 313
                 ***********955 PP

>> Gemini_AL1_M  Geminivirus rep protein central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0     0.052   4.7e+02      15      51 ..      84     120 ..      73     133 .. 0.85
   2 !   15.2   0.0   1.9e-06     0.017      15      53 ..     258     299 ..     251     307 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.052
  Gemini_AL1_M  15 nasSkeealeiikeelPkDyvlkldnlesnadkifpe 51 
                   n+++ +e  ei+ e   + +v  + ++e+ ++++f+ 
    EFC36430.1  84 NKQALKELVEILDETPDMGFVDTHVHFEYILQRVFNA 120
                   6677788899999999999***************976 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 1.9e-06
  Gemini_AL1_M  15 nasSkeealeiikeelPkDyvlkldnlesn...adkifpeip 53 
                   ++++ ++al+i+k++lPkD+ ++ + ++     a+k+  + p
    EFC36430.1 258 AREAEDDALQIMKDNLPKDWKIHVHCFTDRlefAQKLISHFP 299
                   567899******************999865111456555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1232  (0.0687155); expected 358.6 (0.02)
Passed bias filter:                      646  (0.036031); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 2045.86
//
Query:       EFC36431.1  [L=391]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.034   13.7   0.0      0.048   13.2   0.0    1.3  1  Exo_endo_phos    Endonuclease/Exonuclease/phosphatase family
      0.069   12.5   0.1       0.11   11.8   0.1    1.3  1  Methyltrans_RNA  RNA methyltransferase


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   5.4e-06     0.048       2     206 ..     157     334 ..     117     357 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 5.4e-06
                    EEEESTGCHHHHTHHHHHHHHHHHHHHCTT......SEEEEEEEBSCTCHHHHHHHHHTTCEEEEECCH...........ECSSSTTSSEEEEEEC CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........xxxxxxxxxxxxxxxx RF
  Exo_endo_phos   2 twNvngqaspalgssrrsdrladlltayda......DvlgLQEvdddelsriplllalggflgasstsp...........tgggggggnggavlsr 80 
                    +wN+ g       s++ s+   + +++ +       D+ ++QE+  +e    ++  +           +            +++ + ++ g+++++
     EFC36431.1 157 SWNLPG-------SNPTSKSMVKTFKEKHGeliekcDLSFFQEFATGENGACDAFVK-----------RfdkeffaiqnlKRFNKKSDDFGVIMWS 234
                    566666.......33446666666666633344444777788844444444333332...........1223333334445677788888888888 PP

                    STEEEEEEEEEEETSSSSGCEEEEEEEEEEEEEEE.........CCCHHGHHHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-SSSTSGGGBSCGHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  81 fpltslfrrtfiefndlvaalrreplaakleqlni.........ashrdhdlvrdlqllalllqvealnadrgapvivaGDfNarpsdddsrvlrt 167
                     +   +                     +k+  ++          + h ++   r+++  ++ l++ + ++ + ++++ aGD N+  +    +++  
     EFC36431.1 235 EKYSLI---------------------EKEFGFQGmrsinptmiNVHLSNTITREREEELEELFNYISSKLKRKSFVCAGDWNTELNLEKIHSISH 309
                    888555.....................2333333366777777888999999********************************999999999888 PP

                    HHHHCTTTHHSSCESCETTTTTTTTTTTEB-BEEEEEEC CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 168 rglalapapvglyllgggptptyvtraggsrlDrilasp 206
                        +                  +t   g  +D+il+s+
     EFC36431.1 310 FSSIDQS--------------KQRTTKSGRKIDHILFSD 334
                    8888876..............89999999999******6 PP

>> Methyltrans_RNA  RNA methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   1.3e-05      0.11      39     144 ..     251     357 ..     238     387 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.3e-05
                      EEESSEEEEEEEEEEE---SSSSE..EEEEEE--SSHHHHHHHHHHHHTT-SEEEEEE-TTSSS...HHHHHHHHHHHHHHHHHHHHHHT-SS- CS
  Methyltrans_RNA  39 eiskkkvtvkilekeeenkespek..itlaqalpkgdklelilqkatElGvseivplisersvvkldekkkdkklerwqkilieAaeQsgrtrl 130
                      +i+ + ++v++ +  + ++e++ +    ++ + +k + +  + +  tEl  ++i+ +    s   +++++  k+ ++++ il +   Q++  ++
       EFC36431.1 251 SINPTMINVHLSNTITREREEELEelFNYISSKLKRKSFVCAGDWNTELNLEKIHSISHFSS-IDQSKQRTTKSGRKIDHILFSDDFQCKLCVV 343
                      55666666666666666666666566999999999999999999***********9877777.55569************************** PP

                      -EEEEEEEHHHHHH CS
  Methyltrans_RNA 131 pevkepislkelle 144
                      pe+  + + +++ +
       EFC36431.1 344 PEILAFSESNHFPK 357
                      *****999998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2266.91
//
Query:       EFC36432.1  [L=390]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-25   87.3  33.2    0.00028   20.7   0.2   12.6 13  LRR_6            Leucine Rich repeat
    4.5e-23   80.8  29.8    1.4e-07   31.2   2.2    7.3  9  LRR_8            Leucine rich repeat
      1e-17   63.9  35.4    0.00073   19.9   2.2    8.7 11  LRR_4            Leucine Rich repeats (2 copies)
      4e-09   35.8  21.5        4.8    8.1   0.2   10.9  9  LRR_1            Leucine Rich Repeat
    5.4e-06   26.0   7.5    0.00088   18.8   1.3    3.3  4  LRR_9            Leucine-rich repeat
  ------ inclusion threshold ------
      0.018   15.1   0.2       0.17   12.0   0.1    2.4  2  EFhand_Ca_insen  Ca2+ insensitive EF hand
       0.34   10.7   9.7        2.1    8.1   2.3    2.8  2  FTH              FTH domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.2       0.1   2.6e+02       4      12 ..      28      36 ..      26      42 .. 0.76
   2 !    6.4   0.1    0.0042        11       4      16 ..      52      65 ..      52      69 .. 0.84
   3 ?   -2.9   0.0         4     1e+04       4      10 ..     101     107 ..     100     109 .. 0.79
   4 !    8.7   0.0   0.00076         2       5      17 ..     126     138 ..     123     139 .. 0.90
   5 ?    4.2   0.1     0.022        56       5      23 ..     150     168 ..     146     169 .. 0.79
   6 !   20.7   0.2   1.1e-07   0.00028       3      23 ..     172     192 ..     170     193 .. 0.93
   7 !   16.0   0.0   3.6e-06    0.0091       4      23 ..     197     216 ..     194     217 .. 0.92
   8 ?    5.2   0.0      0.01        26       4      24 .]     221     241 ..     219     241 .. 0.85
   9 ?    3.1   0.2     0.047   1.2e+02       3      16 ..     244     257 ..     242     259 .. 0.86
  10 !    6.4   0.0    0.0041        11       3      16 ..     269     282 ..     267     284 .. 0.82
  11 !   10.4   0.2   0.00022      0.56       4      18 ..     293     307 ..     290     313 .. 0.86
  12 !    9.8   0.0   0.00035      0.89       3      23 ..     316     336 ..     314     337 .. 0.81
  13 !    8.4   0.1   0.00098       2.5       4      14 ..     342     352 ..     339     352 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.1
       LRR_6  4 hLteLdLsg 12
                +Lt+Ld+s 
  EFC36432.1 28 YLTSLDISN 36
                79*****96 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0042
       LRR_6  4 hLteLdLsgNd.Ig 16
                +L+eLd+s N  I+
  EFC36432.1 52 TLKELDVSLNSdIT 65
                8*********8887 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 4
       LRR_6   4 hLteLdL 10 
                 +Lt L++
  EFC36432.1 101 NLTDLNI 107
                 7999997 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.00076
       LRR_6   5 LteLdLsgNdIgD 17 
                 Lt+ d+s+N+Ig 
  EFC36432.1 126 LTAIDISFNNIGT 138
                 9**********97 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.022
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L+ L  +gN+I+ +Ga+ +
  EFC36432.1 150 LRILKANGNQINSDGAKLI 168
                 55555579********976 PP

  == domain 6  score: 20.7 bits;  conditional E-value: 1.1e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  hLt+L+++ N+Ig eG++++
  EFC36432.1 172 KHLTHLSINNNQIGKEGVKCI 192
                 6******************98 PP

  == domain 7  score: 16.0 bits;  conditional E-value: 3.6e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 hLt+L + +N I D+G++ +
  EFC36432.1 197 HLTHLAVGSNRIKDKGLKYI 216
                 9****************977 PP

  == domain 8  score: 5.2 bits;  conditional E-value: 0.01
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  L  L++ +N+I ++G++ L+
  EFC36432.1 221 RLNFLSIYDNGIKGKGVKYLS 241
                 57778999*********9885 PP

  == domain 9  score: 3.1 bits;  conditional E-value: 0.047
       LRR_6   3 thLteLdLsgNdIg 16 
                 + L +Ld+ +N+I+
  EFC36432.1 244 SRLVTLDIHSNGID 257
                 6799********98 PP

  == domain 10  score: 6.4 bits;  conditional E-value: 0.0041
       LRR_6   3 thLteLdLsgNdIg 16 
                 t L++Ld+s+N +g
  EFC36432.1 269 TQLRSLDISDNYFG 282
                 67*********666 PP

  == domain 11  score: 10.4 bits;  conditional E-value: 0.00022
       LRR_6   4 hLteLdLsgNdIgDe 18 
                  Lt+L++s Nd++D+
  EFC36432.1 293 QLTKLNISENDLTDK 307
                 59************7 PP

  == domain 12  score: 9.8 bits;  conditional E-value: 0.00035
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 + Lt+Ld++gN+I  eG + +
  EFC36432.1 316 SQLTYLDIRGNEIIYEGFKEI 336
                 67**********988886666 PP

  == domain 13  score: 8.4 bits;  conditional E-value: 0.00098
       LRR_6   4 hLteLdLsgNd 14 
                 +Lt+LdLs+N+
  EFC36432.1 342 YLTYLDLSDNQ 352
                 7*********7 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.2    0.0022       5.6       3      36 ..      29      62 ..      27      70 .. 0.92
   2 ?    4.6   1.4     0.011        27       2      58 ..      52     109 ..      51     112 .. 0.92
   3 !    8.2   0.7   0.00082       2.1       3      61 .]      78     136 ..      76     136 .. 0.84
   4 !   19.1   0.5   3.2e-07   0.00082      15      61 .]     113     160 ..     100     160 .. 0.81
   5 !   22.8   0.6   2.2e-08   5.6e-05      10      61 .]     157     208 ..     156     208 .. 0.96
   6 !   19.0   0.3   3.4e-07   0.00087       2      61 .]     197     256 ..     196     256 .. 0.98
   7 !   17.7   0.6   8.5e-07    0.0022       2      60 ..     221     280 ..     220     281 .. 0.92
   8 !   31.2   2.2   5.3e-11   1.4e-07       2      61 .]     270     328 ..     269     328 .. 0.93
   9 !    5.9   0.0    0.0041        10      23      36 ..     339     352 ..     334     366 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0022
                -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS- CS
       LRR_8  3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNl 36
                LtsLd+sn +l++    +  ++  Lk+Ld s N+
  EFC36432.1 29 LTSLDISNKHLSDEYIATIGNWDTLKELDVSLNS 62
                9******************************994 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.011
                 T-SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +L++Ld+s N+ +t+ + +  +  s L+ L+  + +++t   + +s +++L+ L++ +
  EFC36432.1  52 TLKELDVSLNSdITERGIGIISEKSLLNKLSVHSMTISTKGFELISRMKNLTDLNIMQ 109
                 699999999999**9999999999***************999************9876 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00082
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L++L++++  ++  + e  ++++nL+ L++ +  l+    + +s +++L+ +d+s N++
  EFC36432.1  78 LNKLSVHSMTISTKGFELISRMKNLTDLNIMQTVLDIEKIKFISEMEQLTAIDISFNNI 136
                 666777777777777778899************9988777899**************97 PP

  == domain 4  score: 19.1 bits;  conditional E-value: 3.2e-07
                 EE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  15 slddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++++  F + +++L+ +d+s N++ t + g +  L++Lr L  +gN++
  EFC36432.1 113 DIEKIKFISeMEQLTAIDISFNNIGTDELGLICKLEKLRILKANGNQI 160
                 4555555555************************************98 PP

  == domain 5  score: 22.8 bits;  conditional E-value: 2.2e-08
                 TS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  10 nNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  N+++s + +  k+l++L++L+++nN++     +++  L++L++L + +Nr+
  EFC36432.1 157 GNQINSDGAKLIKDLKHLTHLSINNNQIGKEGVKCIGELEHLTHLAVGSNRI 208
                 69999*********************************************97 PP

  == domain 6  score: 19.0 bits;  conditional E-value: 3.4e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L + +Nr+++ + +   +l++L+ L++ +N ++    + +s+L++L  Ld+ +N +
  EFC36432.1 197 HLTHLAVGSNRIKDKGLKYIGRLQRLNFLSIYDNGIKGKGVKYLSSLSRLVTLDIHSNGI 256
                 8*********************************************************86 PP

  == domain 7  score: 17.7 bits;  conditional E-value: 8.5e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNr 60 
                 +L+ L++ +N +++ + +  ++ls+L +Ld+ +N +++    + +s +++LrsLd+s+N 
  EFC36432.1 221 RLNFLSIYDNGIKGKGVKYLSSLSRLVTLDIHSNGIDSsKTTKLISEMTQLRSLDISDNY 280
                 57778999999999999*******************99889999**************96 PP

  == domain 8  score: 31.2 bits;  conditional E-value: 5.3e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+sLd+s+N++ +   ++ ++l++L+ L++s+N lt   + ++s+L++L++Ld++gN +
  EFC36432.1 270 QLRSLDISDNYFGNSF-KCITNLKQLTKLNISENDLTDKFASSISQLSQLTYLDIRGNEI 328
                 79*********99966.57788************************************87 PP

  == domain 9  score: 5.9 bits;  conditional E-value: 0.0041
                 T-TT--EEE--SS- CS
       LRR_8  23 glsnLkvLdLsnNl 36 
                 +l+ L++LdLs+N+
  EFC36432.1 339 KLEYLTYLDLSDNQ 352
                 57778888888886 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.2    0.0018       4.7       3      39 ..      29      64 ..      22      69 .. 0.78
   2 ?    4.2   0.1     0.024        62      19      39 ..      95     114 ..      77     118 .. 0.63
   3 !    8.1   0.4    0.0014       3.6       1      36 [.     100     136 ..     100     143 .. 0.70
   4 !   19.9   2.2   2.9e-07   0.00073       2      38 ..     149     186 ..     148     195 .. 0.86
   5 !   18.4   0.3   8.1e-07    0.0021       1      38 [.     172     210 ..     172     215 .. 0.83
   6 !    5.9   0.0    0.0071        18       2      33 ..     197     230 ..     196     241 .. 0.79
   7 !    9.6   0.3    0.0005       1.3       2      37 ..     221     257 ..     220     264 .. 0.80
   8 !   15.9   0.6     5e-06     0.013       2      42 ..     245     291 ..     244     293 .. 0.79
   9 !   15.8   2.5   5.6e-06     0.014       1      40 [.     269     305 ..     269     313 .. 0.77
  10 !   17.9   0.4   1.2e-06     0.003       1      33 [.     292     326 ..     292     335 .. 0.80
  11 !   13.8   0.1   2.3e-05     0.058       2      35 ..     317     352 ..     316     364 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0018
                --EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4  3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39
                L++Ld+sn +l+d     +++ + LkeLd+s N   +d+
  EFC36432.1 29 LTSLDISNKHLSDEYIatIGNWDTLKELDVSLN---SDI 64
                899****99***944455446888999998545...455 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.024
                 HHH.-TT--EEE-.-S-----G CS
       LRR_4  19 lek.lpnLkeLdLsgNnlitdl 39 
                 l + ++nL+ L++  +  + d+
  EFC36432.1  95 LISrMKNLTDLNI--MQTVLDI 114
                 3345********9..3234455 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.0014
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 +nL+ L++ +  + di+    ++ + +L+ +d+s+N +i
  EFC36432.1 100 KNLTDLNIMQ-TVLDIEKikfISEMEQLTAIDISFN-NI 136
                 6888899998.5444555341445*********999.44 PP

  == domain 4  score: 19.9 bits;  conditional E-value: 2.9e-07
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 +L++L  ++Nq+ + +  l k l++L++L++ +Nn+i++
  EFC36432.1 149 KLRILKANGNQINSDGAkLIKdLKHLTHLSI-NNNQIGK 186
                 8************644477777*********.8889965 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 8.1e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L+++nNq+ + +   ++ l +L++L + g n+i+d
  EFC36432.1 172 KHLTHLSINNNQIGKEGVkcIGELEHLTHLAV-GSNRIKD 210
                 68************988885445*******99.6558866 PP

  == domain 6  score: 5.9 bits;  conditional E-value: 0.0071
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgN 33 
                 +L++L  ++N+++d +l  + + l  L  L++ +N
  EFC36432.1 197 HLTHLAVGSNRIKDKGLkyI-GrLQRLNFLSIYDN 230
                 79***********9555532.55999999999666 PP

  == domain 7  score: 9.6 bits;  conditional E-value: 0.0005
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L +L++ +N ++  +   l++l  L +Ld+++N  i+
  EFC36432.1 221 RLNFLSIYDNGIKGKGVkyLSSLSRLVTLDIHSN-GID 257
                 7999*********644478889*********777.554 PP

  == domain 8  score: 15.9 bits;  conditional E-value: 5e-06
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S...-----GGGG CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgN...nlitdldeL 42 
                 +L +Ld+++N + +     l + +++L++Ld+s+N   n  + +++L
  EFC36432.1 245 RLVTLDIHSNGIDSSKTtkLISeMTQLRSLDISDNyfgNSFKCITNL 291
                 6899*********9777895555*********999555555555555 PP

  == domain 9  score: 15.8 bits;  conditional E-value: 5.6e-06
                 SS--EEE--SS---.E-S-HHH-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLsgNnlitdld 40 
                 ++L++Ld+s+N    ++  + +l++L++L++s+N    dl+
  EFC36432.1 269 TQLRSLDISDNYFGnSFKCITNLKQLTKLNISEN----DLT 305
                 68*******8777733222556************....775 PP

  == domain 10  score: 17.9 bits;  conditional E-value: 1.2e-06
                 SS--EEE--SS---.E-S-.HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqlt.dipl.leklpnLkeLdLsgN 33 
                 ++L++L++s N lt ++ + +++l +L++Ld+ gN
  EFC36432.1 292 KQLTKLNISENDLTdKFASsISQLSQLTYLDIRGN 326
                 58************554444447*********888 PP

  == domain 11  score: 13.8 bits;  conditional E-value: 2.3e-05
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnl 35 
                 +L++Ld+++N +   ++   +ekl  L++LdLs+N +
  EFC36432.1 317 QLTYLDIRGNEIIYEGFkeiCEKLEYLTYLDLSDN-Q 352
                 79***********5555555448999999***999.3 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.073   1.9e+02       2      20 ..      29      47 ..      28      50 .. 0.81
   2 ?    1.4   0.0       0.3   7.7e+02       2      12 ..      53      63 ..      52      77 .. 0.77
   3 ?    2.4   0.2      0.15   3.8e+02       2      14 ..     126     138 ..     125     171 .. 0.75
   4 !    7.0   0.6    0.0044        11       1      21 [.     173     193 ..     173     243 .. 0.92
   5 ?    0.3   0.0       0.7   1.8e+03       1      12 [.     245     256 ..     245     266 .. 0.79
   6 !    8.1   0.2    0.0019       4.8       1      21 [.     270     286 ..     270     291 .. 0.76
   7 !    7.8   0.1    0.0024       6.1       1      22 [.     293     314 ..     293     315 .. 0.90
   8 ?    4.6   0.0     0.027        68       1      12 [.     317     328 ..     317     338 .. 0.81
   9 ?    3.4   0.0     0.068   1.7e+02       2      11 ..     343     352 ..     342     364 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.073
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                L++Ld+sn +l++  ++++
  EFC36432.1 29 LTSLDISNKHLSDEYIATI 47
                99******99988777766 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.3
       LRR_1  2 LrhLdLsnnpl 12
                L++Ld+s n+ 
  EFC36432.1 53 LKELDVSLNSD 63
                9*****98884 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.15
       LRR_1   2 LrhLdLsnnpllg 14 
                 L+ +d+s n+++ 
  EFC36432.1 126 LTAIDISFNNIGT 138
                 7888999998733 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0044
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L+hL ++nn+++  +  ++ 
  EFC36432.1 173 HLTHLSINNNQIGKEGVKCIG 193
                 69*********9877777765 PP

  == domain 5  score: 0.3 bits;  conditional E-value: 0.7
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L +Ld+ +n +
  EFC36432.1 245 RLVTLDIHSNGI 256
                 5889***99987 PP

  == domain 6  score: 8.1 bits;  conditional E-value: 0.0019
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +Lr+Ld+s+n ++    nsf+
  EFC36432.1 270 QLRSLDISDNYFG----NSFK 286
                 59*********95....4443 PP

  == domain 7  score: 7.8 bits;  conditional E-value: 0.0024
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L++s n l+++ ++s++ 
  EFC36432.1 293 QLTKLNISENDLTDKFASSISQ 314
                 599*************999986 PP

  == domain 8  score: 4.6 bits;  conditional E-value: 0.027
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+++n +
  EFC36432.1 317 QLTYLDIRGNEI 328
                 599*******98 PP

  == domain 9  score: 3.4 bits;  conditional E-value: 0.068
       LRR_1   2 LrhLdLsnnp 11 
                 L++LdLs+n+
  EFC36432.1 343 LTYLDLSDNQ 352
                 99******97 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.0   0.4    0.0062        16      91     146 ..     103     154 ..      34     156 .. 0.81
   2 !   18.8   1.3   3.4e-07   0.00088      40     128 ..     122     211 ..      94     227 .. 0.86
   3 !    8.5   0.4   0.00051       1.3      48     146 ..     226     322 ..     218     325 .. 0.77
   4 ?    4.2   0.5     0.011        28      40     102 ..     290     355 ..     262     376 .. 0.54

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0062
       LRR_9  91 eelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                 +      n +q + d++ +  ++++e l+ ++ +  n     l +i kl++lr+l 
  EFC36432.1 103 T----DLNIMQTVLDIEKIKFISEMEQLTAIDISFNNIGTDELGLICKLEKLRILK 154
                 2....347789999999999999999999999999999999999999999999985 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 3.4e-07
       LRR_9  40 tldqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                  ++q+ +id+s n+i   +l  +  l++l++l  n n+i   + +l + l +l++l ++nn++ + + ++ + +l++l+ l++ +n + +k
  EFC36432.1 122 EMEQLTAIDISFNNIgtDELGLICKLEKLRILKANGNQINSDGAKLIKDLKHLTHLSINNNQIGKEG-VKCIGELEHLTHLAVGSNRIKDK 211
                 5789**********944478888999*************************************9865.6999*********9999988765 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00051
       LRR_9  48 dlsdndir..kldgfPllkrlktlllnnnrivri.aegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlr 143
                  + dn i+   +  +  l rl tl + +n i    + +l   + +l++l +++n + +   ++ +++lk+l+ l + +n +t+k       i +l ql+
  EFC36432.1 226 SIYDNGIKgkGVKYLSSLSRLVTLDIHSNGIDSSkTTKLISEMTQLRSLDISDNYFGNS--FKCITNLKQLTKLNISENDLTDKFA---SSISQLSQLT 319
                 5678888622477788899***********975415678888999*********99975..5699**************9998753...3456666666 PP

       LRR_9 144 lld 146
                  ld
  EFC36432.1 320 YLD 322
                 666 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.011
       LRR_9  40 tldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivria.egleevlPnleelvltnnelqe 102
                  l q+  +++s+nd+ +    ++  l +l  l +  n i+  + +++ e l  l+ l l++n+ +e
  EFC36432.1 290 NLKQLTKLNISENDLTDkfASSISQLSQLTYLDIRGNEIIYEGfKEICEKLEYLTYLDLSDNQTNE 355
                 345666666666666431134556666666666666665432214444445555555555555444 PP

>> EFhand_Ca_insen  Ca2+ insensitive EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.44   1.1e+03      18      35 ..      25      42 ..      16      46 .. 0.85
   2 ?   12.0   0.1   6.6e-05      0.17       3      41 ..     324     363 ..     322     384 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.44
                     TSSSEEHHHHHHH-TTCH CS
  EFhand_Ca_insen 18 gKpYvTeedLrrellpeq 35
                     + +Y T +d+  ++l ++
       EFC36432.1 25 ELKYLTSLDISNKHLSDE 42
                     568*********999987 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 6.6e-05
                      STHHHHHCHHHHHCTTSSSEEHHHHHHH-TTCHH.HHHHC CS
  EFhand_Ca_insen   3 dsaeqveeaFralaggKpYvTeedLrrellpeqa.eylie 41 
                         e + e F+++ ++ +Y T +dL  + + e+a ++l++
       EFC36432.1 324 RGNEIIYEGFKEICEKLEYLTYLDLSDNQTNEKAiSFLAS 363
                      5678899***************************899865 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.4    0.0026       6.7      42     109 ..     124     192 ..     100     199 .. 0.84
   2 ?    8.1   2.3   0.00083       2.1      21     113 ..     250     340 ..     235     374 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0026
         FTH  42 gtLeeIel.sseeeeeefeelveleQWKnAkklkiessklssfpiehlfhFeefeikldkfsvedaiki 109
                 ++L  I++ +++  ++e+  +++le  +  k    + +++ ++ i++l h+++++i+ +++ +e +++i
  EFC36432.1 124 EQLTAIDIsFNNIGTDELGLICKLEKLRILKANGNQINSDGAKLIKDLKHLTHLSINNNQIGKEGVKCI 192
                 679999998899999**********9996666666666665668*************999999988877 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00083
         FTH  21 klsleglsfkdvasiLssfkagtLeeIelsseeeeeefeelveleQWKnAkklkiessklssfpiehlfhFeefeikldkfsvedaikirdil 113
                  ++ +g++ +++++++s + +  L+++++s+++  ++f+ +++l+Q  +    + +  + ++ +i +l++++ ++i+ +++  e  ++i ++l
  EFC36432.1 250 DIHSNGIDSSKTTKLISEMTQ--LRSLDISDNYFGNSFKCITNLKQLTKLNISENDLTDKFASSISQLSQLTYLDIRGNEIIYEGFKEICEKL 340
                 566667777777777776655..************************9998888888888888*************99999887766665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (390 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       628  (0.0350271); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 2370.61
//
Query:       EFC36433.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1538.06
//
Query:       EFC36434.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.1e-08   32.2   0.1    9.2e-08   31.8   0.1    1.1  1  Ras       Ras family
  ------ inclusion threshold ------
      0.034   13.6   0.0      0.036   13.5   0.0    1.0  1  Arf       ADP-ribosylation factor family
      0.078   12.5   0.1      0.094   12.2   0.1    1.1  1  GTP_EFTU  Elongation factor Tu GTP binding domain
       0.11   12.8   0.0       0.17   12.1   0.0    1.3  1  Roc       Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.8   0.1     2e-11   9.2e-08      55     156 ..      15     128 .]       9     128 .] 0.82

  Alignments for each domain:
  == domain 1  score: 31.8 bits;  conditional E-value: 2e-11
                 ETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHST...TTSEEEEEEETTTGGG....G-SS-HHHHHHHH.....HHHTSEEEEE CS
         Ras  55 TAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrvae...envpivLvGnKvDlee....kravsteegeela.....kelglkflet 141
                  AG ++f++++++y + +++++ v ++ + ++ +++++ v  i+++++   +++p++ v nK+Dl e    k+++++ + e ++     + l++  let
  EFC36434.1  15 IAGPQDFDAFKNKYTKFGNCFIGVCSVGDFQTVKSLRERVGYITKIKDrllNDFPMLFVINKTDLLEeikgKEVIENYRKEIFSiieefSLLNTSILET 113
                 59****************************99999998777777777777799************99888766666655554445544345568899** PP

                 BTTTTCTHHHHHHHH CS
         Ras 142 SAktnenveeafeel 156
                 SAk++e v++++ee+
  EFC36434.1 114 SAKKRESVTKIYEEI 128
                 **********99886 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0     8e-06     0.036      71     164 ..      21     121 ..       5     128 .] 0.72

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 8e-06
                 GGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHHCTSGC..CTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSS.....SSSSEEEEEEBTTTTB CS
         Arf  71 lRplWknYfektdavifvvDsadreRleeakeeLkalleeee..lkevallvlaNKqDlpealseeelrellgleelk.....gkrkleiqkcsavkge 162
                    + ++Y++  +  i v  + d + +++ +e +  +++ ++  l++ ++l + NK Dl e ++ +e+ e+   e  +     +  + +i ++sa k+e
  EFC36434.1  21 FDAFKNKYTKFGNCFIGVCSVGDFQTVKSLRERVGYITKIKDrlLNDFPMLFVINKTDLLEEIKGKEVIENYRKEIFSiieefSLLNTSILETSAKKRE 119
                 5556677888888888888999999999999999888765442288*********************99988877755222333445555555555555 PP

                 TH CS
         Arf 163 gl 164
                  +
  EFC36434.1 120 SV 121
                 54 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   2.1e-05     0.094     121     187 ..      66     127 ..      53     128 .] 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.1e-05
                 TTTEEEEEEESCGST.HHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHH CS
    GTP_EFTU 121 egvpiivfiNKmDrl.kaelkeiveevkqklsrkeeklekygekgekevpvvfgSalkgegvktllea 187
                 ++ p+ ++iNK D l + + ke++e++++++    + +e++      +++++ +Sa+k e v+++ e 
  EFC36434.1  66 NDFPMLFVINKTDLLeEIKGKEVIENYRKEI---FSIIEEFSLL---NTSILETSAKKRESVTKIYEE 127
                 67899**********8778888888888888...4555555444...4689*******9999988775 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   3.7e-05      0.17      59     120 .]      12      79 ..       4      79 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.7e-05
                 EEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHHH...HHHHHHHHCSSS.-EEEEEE-TTT CS
         Roc  59 niWDtaGqerfrslhplylreaalailvyd...srssenlke...Wlkelkkvagks.pvilvgnkiDl 120
                 +iW +aG ++f++ ++ y +  +++i v+     ++ ++l+e   +++++k++  ++ p+++v+nk+Dl
  EFC36434.1  12 EIW-IAGPQDFDAFKNKYTKFGNCFIGVCSvgdFQTVKSLRErvgYITKIKDRLLNDfPMLFVINKTDL 79 
                 567.8*********************998733333344443334599999998666559********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 873.55
//
Query:       EFC36435.1  [L=158]
Description: Hypothetical protein NAEGRDRAFT_54355 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.11   12.4   0.0       0.16   11.9   0.0    1.4  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   9.1e-06      0.16       4      38 ..      22      56 ..      19      66 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 9.1e-06
  F-box-like  4 LPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldt 38
                +P Ei ++I s++p ++ + l l ++  ++ +l+ 
  EFC36435.1 22 IPMEIQVHICSFVPRKEFSTLLLISKALHQQILRS 56
                8*************************999887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1391  (0.0775838); expected 358.6 (0.02)
Passed bias filter:                      819  (0.0456802); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 960.67
//
Query:       EFC36436.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.2e-05   23.4   0.0    0.00014   22.3   0.0    1.6  1  AAA_16           AAA ATPase domain
    0.00013   21.9   0.1       0.03   14.2   0.0    2.2  2  RsgA_GTPase      RsgA GTPase
    0.00033   19.9   0.0    0.00094   18.4   0.0    1.7  2  DUF815           Protein of unknown function (DUF815)
     0.0028   17.3   0.0      0.006   16.3   0.0    1.5  1  AAA_29           P-loop containing region of AAA domain
      0.003   17.8   0.0     0.0082   16.4   0.0    1.7  1  AAA_22           AAA domain
     0.0035   16.4   0.0     0.0056   15.8   0.0    1.3  1  IIGP             Interferon-inducible GTPase (IIGP)
     0.0052   17.3   0.0      0.016   15.7   0.0    1.9  1  ABC_tran         ABC transporter
     0.0066   16.7   0.1      0.029   14.6   0.0    2.2  2  Roc              Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.013   15.1   0.0      0.027   14.1   0.0    1.5  1  Ras              Ras family
      0.013   15.6   0.0       0.03   14.4   0.0    1.8  1  MMR_HSR1         50S ribosome-binding GTPase
      0.016   14.9   0.8       0.13   11.9   0.0    2.4  2  AAA_24           AAA domain
      0.018   14.5   0.0      0.042   13.4   0.0    1.6  1  AAA_7            P-loop containing dynein motor region
      0.062   13.3   0.2       0.39   10.7   0.0    2.3  3  AAA_5            AAA domain (dynein-related subfamily)
      0.072   12.8   0.0       0.13   11.9   0.0    1.4  1  Sigma54_activat  Sigma-54 interaction domain


Domain annotation for each model (and alignments):
>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.0   1.1e-07   0.00014      25      63 ..     116     157 ..      96     232 .. 0.61

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 1.1e-07
      AAA_16  25 elvllsGesGvGKsslvrellralekd...ggiflrgkcdql 63 
                  ++ll+Ge+G GKssl+ +++r+l ++     i++ g+++ +
  EFC36436.1 116 LNILLIGEKGAGKSSLISTFHRSLHENygeAPIAVIGENRAS 157
                 689***********************9654122233333333 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.0   2.4e-05      0.03      77     126 ..      93     142 ..      71     184 .. 0.78
   2 ?    5.6   0.0      0.01        13      11      94 ..     240     322 ..     221     334 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.4e-05
                  SEEEE--TTTHTTHHHHHHHCTTSEEEEECSTTSSHHHHHHHHCTT---- CS
  RsgA_GTPase  77 yevllvsaktkegleelkellkdktsvlvGqSGvGKStLinallpelelk 126
                  +++   + ++ +  +++ +++++  ++l+G+ G+GKS+Li +++ +l+ +
   EFC36436.1  93 LKFRQKQLNEYTVNNDIIPNVSHLNILLIGEKGAGKSSLISTFHRSLHEN 142
                  34444444555667789999999999**************9998876655 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.01
                  TTEES--EEEEEEESTTTT--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTTHTTHHHHH CS
  RsgA_GTPase  11 pkvaNvdqllivvslkepelslnlldrfLvlaeekgiepvivlnKiDlleeeeeleelkeelealgyevllvsaktkegleelk 94 
                  ++v  + +++i v  ++++  ++ l+ f+ l+ e g +p+ +++KiD   + + l +  + + +  ++++ + + + +++++++
   EFC36436.1 240 TTVQDIPHAVIFVVPANQRNVPSELEDFVNLFLEYGYKPLFAVTKIDAHGSGD-LYAATHLYDTKKTQLVQMFELEYTDVHAIQ 322
                  338888888887777778888999************************99999.555555554444444444433444444444 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   7.3e-07   0.00094      34      80 ..      94     142 ..      67     157 .. 0.70
   2 ?   -2.4   0.0       1.6   2.1e+03     136     154 ..     242     260 ..     239     266 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 7.3e-07
      DUF815  34 dkqkealvent..eqfleglpannvLLwGarGtGKSslvkallneyaee 80 
                 + ++++l e t  +  + + +  n+LL+G++G+GKSsl+ + +++++e+
  EFC36436.1  94 KFRQKQLNEYTvnNDIIPNVSHLNILLIGEKGAGKSSLISTFHRSLHEN 142
                 44455555544223456677778****************9888777665 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.6
      DUF815 136 leakpenvliyaTsNrRhL 154
                 ++  p+ v++ + +N+R++
  EFC36436.1 242 VQDIPHAVIFVVPANQRNV 260
                 778899***********96 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   4.7e-06     0.006       7      39 ..     100     132 ..      96     139 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.7e-06
      AAA_29   7 vNWgtfdghtieidlkg.atlltGpsGsGKSTll 39 
                 +N +t ++  i+   +  ++ll+G+ G+GKS+l+
  EFC36436.1 100 LNEYTVNNDIIPNV-SHlNILLIGEKGAGKSSLI 132
                 68888888766655.4559**************8 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   6.4e-06    0.0082       7      38 ..     117     154 ..     113     198 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 6.4e-06
      AAA_22   7 ilvvtGesGtGKTtllrrlleqldeeakaee......e 38 
                  ++++Ge+G+GK+ l+ +++++l+e +  +       +
  EFC36436.1 117 NILLIGEKGAGKSSLISTFHRSLHENYGEAPiavigeN 154
                 689********************987665556666651 PP

>> IIGP  Interferon-inducible GTPase (IIGP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   4.3e-06    0.0056      30      73 ..     112     153 ..      89     183 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 4.3e-06
                 HHHT--EEEEEEESTTSSHHHHHHHHTT--TTSTTS--SSCHSH CS
        IIGP  30 eiesaklkiavtGdsGnGkssFinaLRliGheeedsAptGvvet 73 
                 ++  ++l+i  +G+ G+Gkss i +     he+ + Ap+ v+  
  EFC36436.1 112 NV--SHLNILLIGEKGAGKSSLISTFHRSLHENYGEAPIAVIGE 153
                 44..4799******************9999*********99953 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   1.3e-05     0.016      14      42 ..     118     146 ..     113     211 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.3e-05
                 EEEEESTTSSHHHHHHHHTTSS--SEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkpteGei 42 
                 + ++Ge GaGKS+L++++ + l+ + Ge 
  EFC36436.1 118 ILLIGEKGAGKSSLISTFHRSLHENYGEA 146
                 679*****************999998886 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   2.3e-05     0.029       2      39 ..     118     158 ..     117     194 .. 0.58
   2 ?   -2.4   0.0       4.2   5.4e+03      76      88 ..     300     312 ..     286     337 .. 0.46

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.3e-05
                 EEEESSTTSSHHHHHHCHCT...-CCC-EEETTTTEEEEEE CS
         Roc   2 vvlvGdsgvGKtsllkrfve...dkfsekekstigvdfltk 39 
                 ++l+G++g+GK+sl++ f +   +++ e   + ig + ++ 
  EFC36436.1 118 ILLIGEKGAGKSSLISTFHRslhENYGEAPIAVIGENRASA 158
                 89*************98876111344444444555444433 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 4.2
                 HHCTSCEEEEEEE CS
         Roc  76 ylreaalailvyd 88 
                 y +++  ++ +++
  EFC36436.1 300 YDTKKTQLVQMFE 312
                 4444333333333 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   2.1e-05     0.027       2      67 ..     118     191 ..     117     200 .. 0.64

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.1e-05
                 EEEEESTTSSHHHHHHHHHH...SSCSSSCTTTSSEEEEEEEEEET.....TEEEEEEEEEETTSGGGHHHHHH CS
         Ras   2 lvlvGdsavGKtslllrfvk...dkFkeeyesTigvdfytkeievd.....gkevkleiwDTAGqeefkslrel 67 
                 ++l+G+++ GK+sl+  f +   +++ e  ++ ig++  ++ ++ +     +   ++  +DT G e f +l+  
  EFC36436.1 118 ILLIGEKGAGKSSLISTFHRslhENYGEAPIAVIGENRASAFTKKKkgyavNLPKSIFAHDTRGLETFLKLELE 191
                 789*************9986111566677777787664443333223221223333445899999999888655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.0   2.4e-05      0.03       2      57 ..     118     193 ..     117     284 .. 0.62

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 2.4e-05
                 EEEEESTTSSHHHHHHHHHT.......S...TEEESSST.TSSSSEEEEEEEETTEEEEEEECGGC..........S CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltg.......e...kaivsdkp.gtTrdinegrvklkgkeielvDtpGl..........i 57 
                 ++++G   +GKS+Li++  +       e   ++i ++++   T++ + + v+l  k+i   Dt Gl          +
  EFC36436.1 118 ILLIGEKGAGKSSLISTFHRslhenygEapiAVIGENRAsAFTKKKKGYAVNLP-KSIFAHDTRGLetflkleleqV 193
                 899***************975555554234223334444367888888888854.6899999999655444332220 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00011      0.13       3      25 ..     116     137 ..     114     164 .. 0.85
   2 ?    0.9   0.2      0.25   3.2e+02      53      97 ..     321     365 ..     267     370 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
      AAA_24   3 lkiliyGpsgiGKTtlakelgpk 25 
                 l+il++G+ g+GK++l++++  +
  EFC36436.1 116 LNILLIGEKGAGKSSLISTF-HR 137
                 689****************9.44 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.25
      AAA_24  53 ldevvelaaeladyktlviDtideleelclaevirqnekaesked 97 
                 ++ ++e+++++  +++  +D +++++  +   +++   ++++k++
  EFC36436.1 321 IQNYTEWDQKNVSIESMALDLLQKAVTRAEGFIQQHMDNEKDKQS 365
                 4556666999999999*********99999988776666566655 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   3.3e-05     0.042      33      63 ..     115     144 ..     102     161 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.3e-05
       AAA_7  33 kkpvllvGptGtGKtviikdllkkldkekyl 63 
                 + ++ll+G++G GK+++i+++ ++l+ e+y 
  EFC36436.1 115 HLNILLIGEKGAGKSSLISTFHRSLH-ENYG 144
                 5689********************99.7765 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       5.6   7.1e+03     114     130 ..      84     100 ..      60     109 .. 0.51
   2 ?   10.7   0.0    0.0003      0.39       1      26 [.     117     142 ..     117     152 .. 0.86
   3 ?   -1.2   0.0       1.5   1.9e+03      60     107 ..     193     241 ..     187     267 .. 0.65

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 5.6
                 -EEEEEESS--.-TT-T CS
       AAA_5 114 frviatanpldrslnel 130
                 f+ i  +n+l++++++l
  EFC36436.1  84 FSQISHYNNLKFRQKQL 100
                 66666666666444444 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.0003
                 EEEEE--SSSSHHHHHHHGGGGBS-- CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnre 26 
                 ++lL+G++G gKs+l+  + + l  +
  EFC36436.1 117 NILLIGEKGAGKSSLISTFHRSLHEN 142
                 689*************9999988555 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.5
                 -----G-SEEEEESGG.G--HHHHHHHHHHHHSSEEE..-SSSEEE--- CS
       AAA_5  60 vraaregeilvlDEve.raesevlnsLlslleerrllleeggelvkakn 107
                 vra+r g+i  + Ev+ +a+ +  + L s+l+++   + + + lv+   
  EFC36436.1 193 VRAMRDGKIGDDVEVKqKASWSLWDYLFSMLSRNPAAILDPDCLVNNTT 241
                 7889999988888886245578888888888888877766666664444 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0    0.0001      0.13      21      49 ..     114     142 ..      94     159 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.0001
                      SSS-EEEECSTTSSHHHHHHHHHHHSTTT CS
  Sigma54_activat  21 tdlsvlitGesGtGKellaraiheaskrk 49 
                      ++l++l+ Ge+G+GK+ l ++ h++ +++
       EFC36436.1 114 SHLNILLIGEKGAGKSSLISTFHRSLHEN 142
                      4699******************9965544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1265  (0.0705561); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        84  (0.00468515); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 2483.42
//
Query:       EFC36437.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.13   12.9   1.0        0.2   12.3   1.0    1.6  1  Ribonuclease_3  Ribonuclease III domain


Domain annotation for each model (and alignments):
>> Ribonuclease_3  Ribonuclease III domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.0   1.1e-05       0.2      26      73 ..      25      72 ..      13     210 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.1e-05
                    SSHHHHHHHHHHHTSHHHHHHHHHCTTCHCCHCHH............. CS
  Ribonuclease_3 26 ahegrlsklrsklvsnenlarlakklglpkflrasefdpprnwlppgy 73
                    ++e++ ++  sk +sn++la++ak+ +l k l +++ + +r+ l   +
      EFC36437.1 25 DYEEQRTTRSSKRLSNKTLANIAKQTKLVKALAEKKPKKQRKFLSLSE 72
                    4588889999***********************888877777666433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1986  (0.11077); expected 358.6 (0.02)
Passed bias filter:                      604  (0.0336884); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 1449.00
//
Query:       EFC36438.1  [L=425]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.2e-16   57.9  24.2    7.3e-14   51.5  24.2    2.1  1  TMEM144          Transmembrane family, TMEM144 of transporter
    1.1e-07   31.5  24.6    4.6e-07   29.5   3.6    2.2  2  Sugar_transport  Sugar transport protein
  ------ inclusion threshold ------
          9    6.1   7.7        1.4    8.6   3.3    1.9  2  SPC25            Microsomal signal peptidase 25 kDa subunit (


Domain annotation for each model (and alignments):
>> TMEM144  Transmembrane family, TMEM144 of transporters
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.5  24.2   1.2e-17   7.3e-14       2     333 ..      58     420 ..      55     422 .. 0.70

  Alignments for each domain:
  == domain 1  score: 51.5 bits;  conditional E-value: 1.2e-17
     TMEM144   2 vGlvaclvssvlfGsmfvPlkkfd..skdGlfvqwvmslaillvglvvaatlgfpkfePlamlgGalyavgnalavpiieriGlavgiLiWntvnclvG 98 
                 vG+vac+++  +fG     +k+++    + +++q+  s  +l+++++v + ++   f    +lg a++  +  l+++ i+ +Gl+v+  +W+ vn+++ 
  EFC36438.1  58 VGVVACIIAWGTFGLPL-KVKWIKeaNMNPIVFQFYFSSMVLITSFIVLIWNEW-YFSFWGILGAAVWVPASLLSLIAIHLLGLGVAQGVWSGVNIITS 154
                 78899998888888542.344554115678*****************9887665.5777789***********************************97 PP

     TMEM144  99 WavtRfGlfgikaqvpksdlLnylGivlvvvggvlflfikevp..............kenetesdtsaleveekkeleedesedddkvskeragavk.. 181
                 ++ +   lf  +  +p    L  + +v+ +vg +  ++  + p              +e+ t++d ++++ e+ + ++ ++ ++++ v        +  
  EFC36438.1 155 FTWG-VALFHSEIGNPYLTALALILMVVGIVGIATCSKW-NLPellpasstetkslvNETVTHYDGNEENPEAPNTFNPEVQNNEQAVE-------Qti 244
                 5544.3477766666655555555555555554444433.4445556655544444433334444444444444444444444444444.......144 PP

     TMEM144 182 .............................rllaillaivagvlyGltlvPviyikdkeelypgasqegldYvfsfylgifltstvilliYsiv...kkn 248
                                               +l +  ++ +gvl G+ +vP  +          +++ g+ Yv+ f +g+  ++++il+iY i+   + +
  EFC36438.1 245 ettqeeeeyptqplsrkekivsilkssknYILGLACSVGVGVLGGSQFVPSRF----------EEKPGVVYVVGFGFGSAGITSAILVIYYIYyiiRYR 333
                 44455889999999999977777777766777777888888888888888544..........3456899*****999887777777666553111333 PP

     TMEM144 249 k..plveselvlPsllaGilwaiav.tsffvanqkLsqvvsyPiiskaPgliaalwsvflfkeikGkrnlillaiavaitli.gvilva 333
                    p+ ++ +v P ++a +lw ++   + +v+  +L  ++  P+ ++a  ++a++ ++++fke++G + ++++ ++  + li g il++
  EFC36438.1 334 VvlPFHPKVAVFPCITA-CLWQVGNvMATYVSMSSLGFTIGLPL-TQASLVVAGICGLLFFKELRGWKAILQFFVSALVFLIpGCILLS 420
                 23378888999999875.9****9625689*************7.577899**********************9998887763666655 PP

>> Sugar_transport  Sugar transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8  13.1   0.00032       1.9      35     128 ..      90     184 ..      60     196 .. 0.73
   2 !   29.5   3.6   7.7e-11   4.6e-07     198     280 ..     337     421 ..     310     422 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00032
  Sugar_transport  35 allfalilflvkqpeltlkillv...slisGllWaigqllqfkalklvgvskamPistglqLvgasLigvlvlgeWstsiqvilGllalilivi 125
                      ++ f+ ++++++ + l ++ + +   ++++ ++W  + ll + a++l+g  +a+ + +g+ ++++  +gv +++   ++ +  l  lalil+v+
       EFC36438.1  90 QFYFSSMVLITSFIVLIWNEWYFsfwGILGAAVWVPASLLSLIAIHLLGLGVAQGVWSGVNIITSFTWGVALFHS--EIGNPYLTALALILMVV 181
                      44555556666666666665555112679999*****************************************95..56666777999999999 PP

  Sugar_transport 126 Giv 128
                      Giv
       EFC36438.1 182 GIV 184
                      986 PP

  == domain 2  score: 29.5 bits;  conditional E-value: 7.7e-11
  Sugar_transport 198 alvekvslkniisGllwaignlfl.llsaqkvGvatafslsqlsvvistlggillLkekktkkelv.lviiGivlilvgavllal 280
                      ++  kv++  +i+  lw +gn++   +s++++G +++  l+q+s+v++ + g+l++ke +  k ++ + ++ +v+++ g++ll+l
       EFC36438.1 337 PFHPKVAVFPCITACLWQVGNVMAtYVSMSSLGFTIGLPLTQASLVVAGICGLLFFKELRGWKAILqFFVSALVFLIPGCILLSL 421
                      6778999999***********875267999******************************9998761556677788889999886 PP

>> SPC25  Microsomal signal peptidase 25 kDa subunit (SPC25)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   3.3   0.00024       1.4      32      78 ..      58     104 ..      55     113 .. 0.91
   2 ?   -2.8   0.1      0.79   4.7e+03      58      69 ..     316     327 ..     284     337 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00024
       SPC25  32 lGylavaiaavaflydykveFeeskpvlaiavvlYfilsgiltlyst 78 
                 +G++a++ia ++f ++ kv++ ++ ++  i+  +Yf  ++++t ++ 
  EFC36438.1  58 VGVVACIIAWGTFGLPLKVKWIKEANMNPIVFQFYFSSMVLITSFIV 104
                 799*********************************99999987765 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.79
       SPC25  58 vlaiavvlYfil 69 
                 ++ +++v+Y+i 
  EFC36438.1 316 ITSAILVIYYIY 327
                 233333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (425 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1292  (0.072062); expected 358.6 (0.02)
Passed bias filter:                      699  (0.0389871); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 2347.90
//
Query:       EFC36439.1  [L=522]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.027   14.4   1.4       0.26   11.3   0.1    2.8  2  FAST_1    FAST kinase-like protein, subdomain 1


Domain annotation for each model (and alignments):
>> FAST_1  FAST kinase-like protein, subdomain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.1     0.025   4.5e+02       9      28 ..     363     385 ..     361     397 .. 0.81
   2 ?   11.3   0.1   1.4e-05      0.26      14      48 ..     461     495 ..     460     498 .. 0.94

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.025
      FAST_1   9 rLNykpe...naeeFfeklesrl 28 
                 rLN+++    +++ Ffe+++++ 
  EFC36439.1 363 RLNFESMndlQRQMFFETFTKSF 385
                 899*9996666899****99875 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 1.4e-05
      FAST_1  14 penaeeFfeklesrlepylsslspeelldavwsLc 48 
                 p+n+  +f++ +  l++++s++  +++l+ ++sL+
  EFC36439.1 461 PQNQKMIFDTKTGTLNKCISKFCCSHWLTSLCSLT 495
                 899999****************************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1144  (0.0638072); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 3255.16
//
Query:       EFC36440.1  [L=786]
Description: hypothetical protein NAEGRDRAFT_82213 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.8e-05   22.9   1.2    0.00013   21.8   1.2    1.6  1  F-box-like   F-box-like
  ------ inclusion threshold ------
      0.019   14.8   0.6      0.043   13.7   0.6    1.7  1  F-box        F-box domain
      0.029   14.7   1.1      0.029   14.7   1.1    3.1  3  PRANC        PRANC domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   1.2   2.1e-08   0.00013       1      46 [.     366     410 ..     366     412 .. 0.95

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 2.1e-08
  F-box-like   1 isrLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrlv 46 
                 i ++P+Ei+ +I+ yLp  +Ll+ +l +   + ++l + +LW+ ++
  EFC36440.1 366 IENIPNEIIYHILPYLPVHELLQFRLLSHVANLICLQD-FLWKDVC 410
                 5789*********************************9.*****99 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.6   7.3e-06     0.043       3      45 ..     366     408 ..     364     411 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 7.3e-06
                 HHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHH CS
       F-box   3 lsrLPsevlrhILerLplsdllalrrVSkgwrilidsdrlwck 45 
                 + + P+e++ hIL +Lp  +ll +r+ S   + ++  d lw+ 
  EFC36440.1 366 IENIPNEIIYHILPYLPVHELLQFRLLSHVANLICLQDFLWKD 408
                 7899***********************9877777777777765 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   1.1   4.8e-06     0.029      30      92 ..     317     386 ..     305     389 .. 0.77
   2 ?    6.0   0.4    0.0025        15      12      52 ..     414     453 ..     407     463 .. 0.84
   3 ?   -3.1   0.2       1.7     1e+04      35      50 ..     766     781 ..     757     784 .. 0.53

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 4.8e-06
       PRANC  30 klkslkiYgklik.kiiksakkrykliekaiev.lnnicsk.....kslWnlLPiEIkykIleyLndkdL 92 
                 +lk+++i++++++ ++i++ + r++++++a ++  ++++++     ++l+ ++P+EI y+Il yL  ++L
  EFC36440.1 317 MLKKMNIFQQVYNfSTINKRRFRRRILDEAKSKeFTEHLKElpiyfNDLIENIPNEIIYHILPYLPVHEL 386
                 456777888877734577777788888877654266677778888999******************9998 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0025
       PRANC  12 nknninllvrlinkkklkklkslkiYgklikkiiksakkry 52 
                 +kn+  +l  l++++k+++l  + iY++ i+ +i  +k+ +
  EFC36440.1 414 CKNH-HFLKPLLSNEKIFNLPYMLIYRNHIQPLIIDYKQIK 453
                 4555.99*************************998887655 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.7
       PRANC  35 kiYgklikkiiksakk 50 
                 k Y+ l+k++ k+akk
  EFC36440.1 766 KKYNHLVKQMKKQAKK 781
                 4455555555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (786 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1211  (0.0675442); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.86u 0.34s 00:00:01.20 Elapsed: 00:00:00.50
# Mc/sec: 4701.33
//
Query:       EFC36441.1  [L=613]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (613 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       991  (0.0552736); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.77u 0.37s 00:00:01.14 Elapsed: 00:00:00.57
# Mc/sec: 3259.06
//
Query:       EFC36442.1  [L=758]
Description: multifunctional enzyme required for beta-oxidation [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.1e-49  167.8   0.0    4.3e-49  166.8   0.0    1.5  1  3HCDH_N      3-hydroxyacyl-CoA dehydrogenase, NAD binding dom
      5e-25   88.2   0.0    8.6e-25   87.5   0.0    1.3  1  ECH_1        Enoyl-CoA hydratase/isomerase
      1e-22   80.6   0.0    2.4e-15   56.9   0.0    2.6  2  3HCDH        3-hydroxyacyl-CoA dehydrogenase, C-terminal doma
    2.4e-17   63.5   0.0    5.2e-17   62.4   0.0    1.4  1  ECH_2        Enoyl-CoA hydratase/isomerase
  ------ inclusion threshold ------
       0.17   11.1   0.0       0.31   10.2   0.0    1.4  1  Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase


Domain annotation for each model (and alignments):
>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  166.8   0.0   1.2e-52   4.3e-49       2     179 ..     337     515 ..     336     516 .. 0.95

  Alignments for each domain:
  == domain 1  score: 166.8 bits;  conditional E-value: 1.2e-52
                 EEEE--SCCHHHHHHHHHHTT-EEEEE-S-HHHHHHHHHHHHH.HHHCCTTTTSS-HHHHCCCHHC.EEEES-HHHHHC-SEEEE-S-SSHHHHHHHHH CS
     3HCDH_N   2 vaviGaGtmGagiaavfasagleVvlvdiseealekalekiek.sleklvekgklkeeeveaalar.isfttdleeavdadlviEavvEnlelKrkvfa 98 
                 +av+GaG+mG gi+++++s+g++V l +++ + le++l++i++  ++k++++gk++e+++++++++ +++  +++ + ++++viEa+ E++++K++v++
  EFC36442.1 337 IAVCGAGQMGCGITQLCLSKGYNVYLKEVEYHYLENGLKRIKNeLYSKQIRSGKVTENQRDEVISKyLETGLKYDPIENCQMVIEAALERIDIKKEVLE 435
                 8*****************************************95567899***********998652789999************************** PP

                 HHHCCS-TTSEEEE--SSS-HHHHCCCSSSGGGEEEEEE-SSTTT--EEEEEE-TT--HHHHHHHHHHHHHTT-EEEEECS CS
     3HCDH_N  99 elekiakpdailasnTSslsiselaealkrperviglHFfnPpplmkLvEvvrgekTseetvatvvelakkigktpvvvkd 179
                 + ++  +++ i+a+nTSs++++ +ae+ + +++viglHFfnP++ m+LvE+++++ Ts+e++a+++++a ++gk p+vv+d
  EFC36442.1 436 RAQAF-NKEIIFATNTSSIPLTSIAEESNMKQNVIGLHFFNPANEMPLVEIIATRYTSQEVLAKAYQFALDLGKIPIVVND 515
                 *9776.79***********************************************************************98 PP

>> ECH_1  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.5   0.0   2.4e-28   8.6e-25      43     183 ..      16     159 ..       5     212 .. 0.87

  Alignments for each domain:
  == domain 1  score: 87.5 bits;  conditional E-value: 2.4e-28
                 EEEEEE.BTSEEEEEB-HHHHHHHHC.HHHHHHHCCHHHHHHHHHHSSSEEEEEE-SEEETHHHHHHHHSSEEEEETTTE..EE-GGGGGTS--CTTCH CS
       ECH_1  43 avvLtG.gdkaFaaGadlkemaeeek.akqallkeevlelwtklytvpkpviaavnGaaigGGlelalacDiviaadnas..fglnelklGlipgaggt 137
                 +  + +     F aGad++ ++     +k+++l+ + + l +++  +p++v+aa+ G ++gGG+el la+  +++++ ++   gl+e+klG++ g+gg 
  EFC36442.1  16 GLMMYSlKKDCFIAGADVNMIYTITDrEKAKTLSRTGQYLTRRIEYLPIVVLAAIHGVCLGGGFELCLAASHRVCSNYSKtyCGLPETKLGILTGSGGC 114
                 55666666789***********98777899999********************************************999988**************** PP

                 HHHHHHHHHHHHHHHHHHT-EEEHHHHHHCTSSSEEESGGGHHHHH CS
       ECH_1 138 qilarkvGkskAeeilllgkkisaqealkvGlvdkvvpeeqlleea 183
                  +l+r +G     +++l g +i+a+ al+ G+vd+v+p e ++++ 
  EFC36442.1 115 VRLPRLIGLDNSIQMILQGSSIGAKSALECGIVDQVFPYE-VEQNN 159
                 **************************************85.34443 PP

>> 3HCDH  3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.9   0.0   6.8e-19   2.4e-15       1      97 []     518     611 ..     518     611 .. 0.96
   2 !   21.0   0.0   1.1e-07   0.00038       3      84 ..     648     732 ..     648     734 .. 0.80

  Alignments for each domain:
  == domain 1  score: 56.9 bits;  conditional E-value: 6.8e-19
                 TTTHHHHHHHHHHHHHHHHHTTSS-HHHHHHHHHHHHHHSSCHHHHHHHHHHHHHHHHHHHHHHHTTTH..GGHH-HHHHHHHHTT--BGGGTBSSSBC CS
       3HCDH   1 GFvvnRvlapllneavrlveegvaspediDaamrlglGlpmGpfelldlvgldvakkilevlaeelger..ayapsplleklveagrlgrktgkgfyky 97 
                 GF ++R+++ +  ea  +v +g + +e+iD+ +++ +G+ +G++ +ld  gldva +++ +la+ l  r  +y+    l++lv+ g  g k+ kgfy y
  EFC36442.1 518 GFLTTRLFVVYCIEATSIVLDG-VPFEEIDQRLQE-FGFSTGVLSMLDHNGLDVAIHVMPILAQNLALRfdHYE---ALKELVKGGNTGVKNRKGFYLY 611
                 9*********************.************.************************99999998865666...********************77 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 1.1e-07
                 THHHHHHHHHHHHHHHHHTTS.S-HHHHHHHHHHHHHHS...SCHHHHHHHHHHHHHHHHHHHHHHHTTTHGGHH-HHHHHHHHTT CS
       3HCDH   3 vvnRvlapllneavrlveegv.aspediDaamrlglGlp...mGpfelldlvgldvakkilevlaeelgerayapsplleklveag 84 
                 +v+R++  l+nea +++eeg+ a pe +D  m  g+G+p    G +  +d +g+    k le l  ++   +  ps+ll ++++++
  EFC36442.1 648 IVDRCILVLVNEASKCIEEGIiALPEAVDISMIMGFGFPsflGGLLSFADSLGIANIVKRLEELSIRYDSVKM-PSKLLVDMAKSN 732
                 799*****************73669**************6655999999999998887777767666666555.367777776665 PP

>> ECH_2  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.4   0.0   1.4e-20   5.2e-17      36     226 ..      14     202 ..       6     225 .. 0.85

  Alignments for each domain:
  == domain 1  score: 62.4 bits;  conditional E-value: 1.4e-20
                 -SEEEEEESSSSECE--B--HHHHHHHHCS-THHHHHHHHHHHHHHHHHC-SS-EEEEE-BEEETHHHHHHTTSSEEEE-T..T-EEE--GGGGT---- CS
       ECH_2  36 vklvvlkgagekafCAGgDvralyeaakegkkeeeeffreeYklnyliatypkpvvalmdGivmGgGvGlsvhgsfrvvte..rtvfAmPEtaIGlfPD 132
                 ++ +++ + ++ +f AG Dv+++y+  +++k++  ++ r+   l  +i+ +p  v+a ++G+++GgG  l + +s+rv ++  +t +  PEt++G+ + 
  EFC36442.1  14 IHGLMMYSLKKDCFIAGADVNMIYTITDREKAK--TLSRTGQYLTRRIEYLPIVVLAAIHGVCLGGGFELCLAASHRVCSNysKTYCGLPETKLGILTG 110
                 566778888899*************99997755..69999999***********************************996337899************ PP

                 TTHHHHHHCSST.THHHHHHHH---B-HHHHHHTTS--EE--GGGHHHHHHHHHTT........--------......----SHHHHHHHHHHHT CS
       ECH_2 133 vGgsyfLsrlpg.elGlylalTGarlkgadalaaglathyvpseklealeeaLaelessdeeaveevleelaeeaeeeeeeselaekreaidrlf 226
                  Gg   L+rl g      + l G++++++ al++g+ ++++p e  ++  e +++++ + +++ve + ++++    ++ + ++l e++e i++++
  EFC36442.1 111 SGGCVRLPRLIGlDNSIQMILQGSSIGAKSALECGIVDQVFPYEVEQNNDEYISKTKPQ-AQDVEFFQRSFEY--IKDLSVQTLPEREELIAEAM 202
                 **********88799999**************************999999999997554.7777777777663..33344577777777887777 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   8.7e-05      0.31     137     191 ..     327     384 ..     293     429 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 8.7e-05
                  CCSS-T..SEEEEES-SHHHHHHHHHHHHHT-EEEEEESSSSSS.TTS-HHHHHHHHH CS
                  xxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxx RF
  Pyr_redox_2 137 klkllp..krivvvGgGyiGvElAaalaklgkevtlveardrll.raldkelsaalee 191
                  +lk ++  +ri+v+G+G  G+ +++   + g++v+l e   + l ++l++   + + +
   EFC36442.1 327 HLKIKQviNRIAVCGAGQMGCGITQLCLSKGYNVYLKEVEYHYLeNGLKRIKNELYSK 384
                  333333669*************************999988888855444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (758 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       619  (0.0345251); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.74u 0.34s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 4181.79
//
Query:       EFC36443.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-18   67.0   0.1    3.2e-18   66.1   0.1    1.5  1  F420_oxidored    NADP oxidoreductase coenzyme F420-dependent
    2.9e-09   37.3   0.0    8.6e-09   35.8   0.0    1.7  2  NAD_binding_2    NAD binding domain of 6-phosphogluconate deh
    2.5e-08   33.5   0.0    4.3e-08   32.7   0.0    1.4  1  2-Hacid_dh_C     D-isomer specific 2-hydroxyacid dehydrogenas
    2.9e-05   24.1   0.2    6.8e-05   22.9   0.0    1.7  2  Shikimate_DH     Shikimate / quinate 5-dehydrogenase
    9.5e-05   22.3   0.1    0.00025   21.0   0.0    1.7  2  3HCDH_N          3-hydroxyacyl-CoA dehydrogenase, NAD binding
     0.0001   22.3   0.4    0.00092   19.2   0.4    2.4  1  NAD_Gly3P_dh_N   NAD-dependent glycerol-3-phosphate dehydroge
     0.0002   21.2   0.0    0.00035   20.4   0.0    1.4  1  Rossmann-like    Rossmann-like domain
    0.00098   18.8   1.7     0.0034   17.0   1.5    2.0  1  ApbA             Ketopantoate reductase PanE/ApbA
     0.0026   17.4   0.0     0.0047   16.5   0.0    1.5  1  UDPG_MGDP_dh_N   UDP-glucose/GDP-mannose dehydrogenase family
     0.0028   17.2   0.0     0.0044   16.6   0.0    1.3  1  IlvN             Acetohydroxy acid isomeroreductase, NADPH-bi
     0.0039   17.4   0.1     0.0089   16.3   0.1    1.6  1  TrkA_N           TrkA-N domain
     0.0053   16.9   0.4      0.013   15.7   0.4    1.6  1  NAD_binding_8    NAD(P)-binding Rossmann-like domain
     0.0054   17.0   0.4       0.02   15.2   0.1    2.1  2  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
     0.0084   16.0   0.0      0.018   15.0   0.0    1.5  1  KR               KR domain
  ------ inclusion threshold ------
      0.015   15.8   0.0      0.033   14.7   0.0    1.8  1  XdhC_C           XdhC Rossmann domain
      0.017   14.6   0.1      0.045   13.2   0.1    1.6  1  Epimerase        NAD dependent epimerase/dehydratase family
      0.023   15.5   0.0      0.046   14.6   0.0    1.5  1  GFO_IDH_MocA     Oxidoreductase family, NAD-binding Rossmann 
      0.036   13.5   0.1      0.079   12.4   0.1    1.6  1  adh_short        short chain dehydrogenase
      0.041   13.1   0.0      0.055   12.7   0.0    1.4  1  FAD_binding_3    FAD binding domain
      0.082   12.8   0.6       0.14   12.1   0.1    1.6  1  NAD_binding_10   NAD(P)H-binding
        0.1   12.7   0.1       0.21   11.7   0.1    1.6  1  Ldh_1_N          lactate/malate dehydrogenase, NAD binding do
       0.15   11.5   0.0       0.24   10.7   0.0    1.3  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase


Domain annotation for each model (and alignments):
>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.1   0.1   3.9e-21   3.2e-18       1      97 []       2      95 ..       2      95 .. 0.94

  Alignments for each domain:
  == domain 1  score: 66.1 bits;  conditional E-value: 3.9e-21
                   EEEEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHHHHHC-EEECECHHHHHH..H-SEEEE-S-HHHHHHHHHHCGHHHHTTSEEEEESS CS
  F420_oxidored  1 kigiiGaGnmgealasgllaagaqpheivvansrnpekaeelaeelgvkvtavdneeaae..eadvvvlavkpedveevlselakdalkgklvisvla 96
                   kigiiGaG++g++la+ l+++g   h +++ansr p+++++ +ee +  +++v+  e ++  + d+++l++++++v+ + ++l++++ ++ +v+++++
     EFC36443.1  2 KIGIIGAGHIGSTLAKLLVQQG---HTVLIANSRGPQTLKQVQEETK--AKPVELLEIVQegDLDIIILTIPFKNVSLLPKNLFQNLPQQVIVVDTCN 94
                   7*********************...********************86..77777******666689******************************99 PP

                   S CS
  F420_oxidored 97 g 97
                   +
     EFC36443.1 95 Y 95
                   5 PP

>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.8   0.0   1.1e-11   8.6e-09       1     105 [.       2     108 ..       2     115 .. 0.80
   2 ?   -1.8   0.0       3.7     3e+03      98     122 ..     136     160 ..     130     169 .. 0.73

  Alignments for each domain:
  == domain 1  score: 35.8 bits;  conditional E-value: 1.1e-11
                    EEEEE--SHHHHHHHHHHHHTT-EEEEE-SSHHHHHHHHHTT..EEE-SSHHHHHHHC..SEEEE-SSSHHHHHHHHHSHCCC--TT-EEEE-S-- CS
  NAD_binding_2   1 kigfiGlGvMGsnmalnllkagykvavynrtkekveelvaeg..akaaesieelvasl..dvvitmvkagkavdeviegllealkkgdilidgsts 92 
                    kig+iG G +Gs +a+ l+++g++v + n +  ++ + v+e+  ak++e +e +v++   d++i+ ++  k+v  + ++l+++l ++ i++d+ + 
     EFC36443.1   2 KIGIIGAGHIGSTLAKLLVQQGHTVLIANSRGPQTLKQVQEEtkAKPVELLE-IVQEGdlDIIILTIPF-KNVSLLPKNLFQNLPQQVIVVDTCNY 95 
                    79***************************66555555555543688887776.55544469******98.789999999****************9 PP

                    -HHHHHHHHHHHH CS
  NAD_binding_2  93 spedtrelakelk 105
                     p      ++el 
     EFC36443.1  96 YPGVRDSPTDELD 108
                    9877666666655 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 3.7
                    HHHHHHHHHTT-EEEEEEEESHHHH CS
  NAD_binding_2  98 relakelkekglkfldaPVSGGeeg 122
                      la + ++kg + +  PV G +  
     EFC36443.1 136 HSLAVKGAKKGQTRIALPVAGNDPS 160
                    5566677788888899999988765 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   0.0   5.3e-11   4.3e-08      38     126 ..       2      92 ..       1      94 [. 0.86

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 5.3e-11
                   EEEEES-SHHHHHHHHHHHHTT-EEEEESSSHHHHH..CHHHHTCEECSHHHHHHH-SEEEE-S--STTTTTSBSHHHHHCSTTTEEEEES CS
  2-Hacid_dh_C  38 tvGiiGlGrIGqavakrlkafgmkviaydrskkkee..eeeelgvelvsleellaesDivslhlpltpetrhlinaeelakmkkgailiNt 126
                   ++GiiG+G+IG+++ak+l + g  v++ + +  ++    +ee++++ v+l e+++e D  ++ l +  ++  l+ ++ ++ +++++i++ t
    EFC36443.1   2 KIGIIGAGHIGSTLAKLLVQQGHTVLIANSRGPQTLkqVQEETKAKPVELLEIVQEGDLDIIILTIPFKNVSLLPKNLFQNLPQQVIVVDT 92 
                   79***********************9999988866555566777899********98766666666678999****************987 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.0   8.4e-08   6.8e-05      14      88 ..       2      72 ..       1      94 [. 0.71
   2 ?   -2.6   0.0       6.6   5.4e+03      65      76 ..     200     211 ..     195     216 .. 0.61

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 8.4e-08
                  EEEEES-SHHHHHHHHHHHCCT-CEEEEEE.SSHHHHHHHHHHHT.ET-EEEEGCGHHHHHHT-SEEEE-SSSSS- CS
  Shikimate_DH 14 kvlliGaGemaelvakhLlakgvkkvvvaN.Rtlerakelaeelkgeeiealkleelkellaeadvvisataseep 88
                  k+ +iGaG +++ +ak L+++g + v++aN R  +  k++ ee k++    ++l e+ +   + d++i  +  +++
    EFC36443.1  2 KIGIIGAGHIGSTLAKLLVQQGHT-VLIANsRGPQTLKQVQEETKAK---PVELLEIVQE-GDLDIIILTIPFKNV 72
                  789*******************99.8888869999999999999777...4444444322.356777777666655 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 6.6
                   EGCGHHHHHHT- CS
  Shikimate_DH  65 kleelkellaea 76 
                   ++++lk++l++a
    EFC36443.1 200 NVDDLKQALHSA 211
                   445555555555 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   3.1e-07   0.00025       1      44 [.       2      46 ..       2      71 .. 0.80
   2 ?   -2.7   0.0       5.5   4.5e+03     155     178 ..     107     131 ..     103     133 .. 0.76

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 3.1e-07
                EEEEE--SCCHHHHHHHHHHTT-EEEEE-S.-HHHHHHHHHHHHH CS
     3HCDH_N  1 kvaviGaGtmGagiaavfasagleVvlvdi.seealekalekiek 44
                k+++iGaG +G+ +a++++++g++V + +   +++l++++e+ ++
  EFC36443.1  2 KIGIIGAGHIGSTLAKLLVQQGHTVLIANSrGPQTLKQVQEETKA 46
                69************************9987356777777777665 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 5.5
                 --HHHHHHHHHHHHHTT-EEEEE.C CS
     3HCDH_N 155 Tseetvatvvelakkigktpvvv.k 178
                  ++e++++   ++++ig+ +v+v +
  EFC36443.1 107 LDKEIITHSEWVSQQIGHSVVKVfN 131
                 5778888888889999999998855 PP

>> NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.4   1.1e-06   0.00092       1      43 [.       2      45 ..       2     129 .. 0.87

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 1.1e-06
                    -EEEE--SHHHHHHHHHHHTTT--EEEE-S-H.HHHHHHHHHSS CS
  NAD_Gly3P_dh_N  1 kiavlGaGswGtalAkvlaenghevrlwvree.elieeineehe 43
                    ki+++GaG  G++lAk+l ++gh+v +   +  +++++++ee +
      EFC36443.1  2 KIGIIGAGHIGSTLAKLLVQQGHTVLIANSRGpQTLKQVQEETK 45
                    79**********************99876554477777776654 PP

>> Rossmann-like  Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   4.3e-07   0.00035      12      91 ..       2      82 ..       1      99 [. 0.67

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 4.3e-07
  Rossmann-like 12 svGiisaGrvGtalgaaleraghvvvgisaisaasreraerrlPdvpvlevedvaara..ellllavPdaelpglvkglaat 91
                   ++Gii+aG++G++l++ l + gh+v   ++    + ++ ++     pv e+ +++++   ++++l++P  +++ l k+l ++
     EFC36443.1  2 KIGIIGAGHIGSTLAKLLVQQGHTVLIANSRGPQTLKQVQEETKAKPV-ELLEIVQEGdlDIIILTIPFKNVSLLPKNLFQN 82
                   89*********************9986655554444444444333333.333444444116799999999988888877766 PP

>> ApbA  Ketopantoate reductase PanE/ApbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   1.5   4.2e-06    0.0034       1      98 [.       3      89 ..       3      96 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 4.2e-06
                EEEES-SHHHHHHHHHHHHHTHCEEEE-SCHHHHHHHHHCEEEEETTCEEEEEECEEECCHSCCCCS-ESEEEE-SSGGGHHHHHHHHGGGECTCEEE CS
        ApbA  1 iailGaGaiGsllaakLakagadvtlilrsrrlealkknGlrltseggeeilrppealsaeekselepidlvivtvKayqteealeeikplldpntvv 98
                i i+GaG iGs+la  L ++g++v + + +           +l+++++e++++p e l+ +   + ++ d++i+t++   +    +++ + l ++ +v
  EFC36443.1  3 IGIIGAGHIGSTLAKLLVQQGHTVLIANSRG--------PQTLKQVQEETKAKPVELLEIV---QEGDLDIIILTIPFKNVSLLPKNLFQNLPQQVIV 89
                89*******************9987766665........3455666666677777777777...7788888888888777777777777777777555 PP

>> UDPG_MGDP_dh_N  UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   5.8e-06    0.0047       1      29 [.       1      29 [.       1      59 [. 0.88

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 5.8e-06
                    SEEEEE--STTHHHHHHHHHHCTSEEEEE CS
  UDPG_MGDP_dh_N  1 mkisviGlGYvGlvtaavlaeighevigv 29
                    mki +iG+G++G + a +l ++gh+v++ 
      EFC36443.1  1 MKIGIIGAGHIGSTLAKLLVQQGHTVLIA 29
                    89************************875 PP

>> IlvN  Acetohydroxy acid isomeroreductase, NADPH-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   5.4e-06    0.0044       6      71 ..       2      70 ..       1      92 [. 0.80

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 5.4e-06
                -EEEES-SHHHHHHHHHHHHTT--EEEEE-TT-HHHHHHHHTT.-EEEEHHHHHHT-SE..EEE-S-HH CS
        IlvN  6 kiaviGyGsqGhaqalnlrdsgldvvvglregsksvkkAkeeg.fevltvaeavkkadv..vmiliPDe 71
                ki +iG G  G + a+ l ++g  v +++ +g +++k+ +ee   + +++ e+v++ d+  +++ iP +
  EFC36443.1  2 KIGIIGAGHIGSTLAKLLVQQGHTVLIANSRGPQTLKQVQEETkAKPVELLEIVQEGDLdiIILTIPFK 70
                89*******************************999998776527899*******99753156666644 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   1.1e-05    0.0089       3      40 ..       5      43 ..       3      68 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.1e-05
                EES-SHHHHHHHHHHHHTTEEEEEEESSH..HHHHHHHHT CS
      TrkA_N  3 iiGlGrvGrslaeeLseggkdvvvidkde..erveelree 40
                iiG+G +G++la+ L ++g+  v+i +++  +++++++ee
  EFC36443.1  5 IIGAGHIGSTLAKLLVQQGH-TVLIANSRgpQTLKQVQEE 43
                9****************774.7888877644667777766 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.4   1.6e-05     0.013       1      24 [.       5      28 ..       5      33 .. 0.94

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.6e-05
                   EE--SHHHHHHHHHHHCCTEEEEE CS
  NAD_binding_8  1 IvGaGlsGlvaAylLakagfdvll 24
                   I+GaG  G+++A lL ++g+ vl+
     EFC36443.1  5 IIGAGHIGSTLAKLLVQQGHTVLI 28
                   9*********************98 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.1   2.4e-05      0.02       1      42 [.       3      41 ..       3      69 .. 0.72
   2 ?   -1.3   0.0       2.9   2.4e+03      50      74 ..     192     217 ..     154     247 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.4e-05
                     EEEE--SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHC CS
  Sacchrp_dh_NADP  1 vliiGaGsvGqavaellarhfdvdaeitvadrskeklealaa 42
                     + iiGaG +G+ +a+ll+++++    + +a     +  + ++
       EFC36443.1  3 IGIIGAGHIGSTLAKLLVQQGHT---VLIANSRGPQTLKQVQ 41
                     789*****************997...6666544444333333 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 2.9
                      EEEE--TTTHHHHHHHHHTTS..SEEE CS
  Sacchrp_dh_NADP  50 eaialdaenyeavLaallkeg..dlvv 74 
                      ++  ++  n+++ L+++l ++  ++ v
       EFC36443.1 192 TPSYCTDLNVDD-LKQALHSAdkTIRV 217
                      555566666666.66666666333333 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   2.2e-05     0.018       8      46 ..       7      45 ..       4      64 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 2.2e-05
                TTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHH CS
          KR  8 GlGgLGlelarwlaekgarhlvllsRsaaadedskalia 46
                G+G++G +la+ l+++g + l+  sR +++ ++ +++++
  EFC36443.1  7 GAGHIGSTLAKLLVQQGHTVLIANSRGPQTLKQVQEETK 45
                79*************************987777776544 PP

>> XdhC_C  XdhC Rossmann domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.0   4.1e-05     0.033       3      45 ..       5      56 ..       3     140 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 4.1e-05
                EE--STTHHHHHHHHHHHTEEEEEEES-GGGG-GGG-TT-SE..........- CS
      XdhC_C  3 ifGaghvaqalarlaaalgfrvtvvdpreefatkerfpeade..........t 45
                i+Gagh++  la+l+ + g +v ++++r   +t ++++e+++          +
  EFC36443.1  5 IIGAGHIGSTLAKLLVQQGHTVLIANSRGP-QTLKQVQEETKakpvelleivQ 56
                99**************************95.3455555443344454444440 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   5.5e-05     0.045       5      62 ..       7      57 ..       3      73 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 5.5e-05
                TTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHCEEEE--TT-HHHHHHHHHH CS
   Epimerase  5 GatGfiGsalvkallekgyevigldrlssasntarledlelveldltdrsalerlfke 62
                G +G iGs l+k l ++g++v+  +++  +  ++ +e          ++++l ++++e
  EFC36443.1  7 G-AGHIGSTLAKLLVQQGHTVLIANSRGPQTLKQVQE------ETKAKPVELLEIVQE 57
                4.5*****************88888774433333333......333333333344443 PP

>> GFO_IDH_MocA  Oxidoreductase family, NAD-binding Rossmann fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   5.6e-05     0.046       1      72 [.       1      69 [.       1      89 [. 0.77

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 5.6e-05
                  EEEEEETTSHHHHHHHHHHHHTTTTEEEEEEECSSHHHHHHHHHHTTHEEESSHHHHHTCTTESEEEE-S-G CS
  GFO_IDH_MocA  1 lrvaiiGaGkigskhlrplnesqrleevvalldpdaeraeavaesfgveaysdleelladpeidavivatpn 72
                  ++++iiGaG igs  + +l  + +++ v  + +++++  ++v e+++++ ++ l e++++ + d++i ++p 
    EFC36443.1  1 MKIGIIGAGHIGSTLA-KLLVQ-QGHTVLIANSRGPQTLKQVQEETKAKPVE-LLEIVQEGDLDIIILTIPF 69
                  689************9.55555.4666666899999999***9999999776.5567776899999999885 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   9.7e-05     0.079       5      48 ..       5      48 ..       2      61 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 9.7e-05
                EESTTSHHHHHHHHHHHHTT-EEEE.EESCHHHHHHHHHHHHHTT CS
   adh_short  5 vtGassGIGraiakelakeGakvvv.vdrseekleevakelkeeg 48
                ++Ga+  IG  +ak l+++G +v++  +r +++l++v +e k++ 
  EFC36443.1  5 IIGAG-HIGSTLAKLLVQQGHTVLIaNSRGPQTLKQVQEETKAKP 48
                56665.6******************88999999999999999874 PP

>> FAD_binding_3  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   6.8e-05     0.055       4      36 ..       3      35 ..       1     127 [. 0.88

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 6.8e-05
                   EEEE--SHHHHHHHHHHHHTTHHEEEEESSSSS CS
  FAD_binding_3  4 VlIVGaGpaGlmlallLseaGvrvvlvekrstt 36
                   + I+GaG  G +la+lL ++G  v++ + r  +
     EFC36443.1  3 IGIIGAGHIGSTLAKLLVQQGHTVLIANSRGPQ 35
                   67*******************999998877655 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.1   0.00017      0.14       3      45 ..       8      50 ..       7      62 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00017
                    TSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHHCTTTCEEEE CS
  NAD_binding_10  3 tGkvGrllvkellargghevtalvRnpeklaeleaeeglevve 45
                     G++G+ l+k l+++g++ + a  R p+ l+++++e +++ ve
      EFC36443.1  8 AGHIGSTLAKLLVQQGHTVLIANSRGPQTLKQVQEETKAKPVE 50
                    79*************75555888999*******9999988887 PP

>> Ldh_1_N  lactate/malate dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   0.00026      0.21       1      25 [.       1      24 [.       1      57 [. 0.87

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00026
                EEEEEETTTSHHHHHHHHHHHHTTS CS
     Ldh_1_N  1 vkvavvGaaGgiGqslalllankkl 25
                +k+ ++Ga G iG++la ll++++ 
  EFC36443.1  1 MKIGIIGA-GHIGSTLAKLLVQQGH 24
                69******.************9954 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0    0.0003      0.24       5      33 ..       7      35 ..       5      61 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0003
                   TTSHHHHHHHHHHHHCT-CCEEEEEEESS CS
  GDP_Man_Dehyd  5 iaGfiGsylaelLlekgyevhgivrrsss 33
                   +aG iGs la+lL+++g++v +   r  +
     EFC36443.1  7 GAGHIGSTLAKLLVQQGHTVLIANSRGPQ 35
                   79******************875544433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              22  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 1634.31
//
Query:       EFC36444.1  [L=410]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-17   62.7   3.0      7e-17   61.9   3.0    1.4  1  TLD       TLD
     0.0019   18.5   0.0     0.0053   17.1   0.0    1.8  1  BTB_2     BTB/POZ domain
  ------ inclusion threshold ------
      0.094   12.9   0.3       0.24   11.6   0.2    1.8  2  EF1_GNE   EF-1 guanine nucleotide exchange domain


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.9   3.0   1.2e-20     7e-17       1     137 [.     262     408 ..     262     409 .. 0.77

  Alignments for each domain:
  == domain 1  score: 61.9 bits;  conditional E-value: 1.2e-20
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl.spkfkvyks..tgknkaylntssdglgfGggqpkf 96 
                 lly+ ++dg++++ ++++++++g t++++++++++ifG+f+s++w+ss+  f  d + f+f++ s ++  ++    ++ +a+ +  ++ ++fG    +f
  EFC36444.1 262 LLYRGTRDGFKATDFHKHCDQQGKTVTIVQSRNGHIFGGFTSNNWESSKG-FRTDPSAFIFKIdSASISRFDIksDSYRNAISCDIESLPSFGL---DF 356
                 69*****************************999***********96655.************95555555541134445666666668****7...67 PP

         TLD  97 sLwids.slekgtsrhs........etfengllsg..aseerfkikdiEVWg 137
                 +L  +  +  +++s+           t+e+++ ++  a++ +f++ +iEV++
  EFC36444.1 357 KLSSSCnENSNSYSNFGhtyqlptgFTYESEQARKylAGSCKFQVVEIEVFK 408
                 77777634445677766445555555555555555***************96 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.0   8.9e-07    0.0053       1      80 [.     122     210 ..     122     223 .. 0.71

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 8.9e-07
                 EEEEETTEEEEEEHHHHH...TSTTSTTTSSGG........GGEETTTTEEEE-S-HHHHHHHHHHHHS...S-B---TTS-HHHHHHH CS
       BTB_2   1 vklnVgGtrfetskstLs...rkpdtlLgkllkte....elddydeetneyffDRspklFetiLnyyrtg..gkLhrpeevelkslleE 80 
                 v+lnVgG +  +         r p+ ++ k+ k      e+ +   e++ +f+D +  +F+ i+++++tg   kL ++e + + +  eE
  EFC36444.1 122 VHLNVGGYILTICMGVFVnsvREPNNVIDKMFKGIiplhETPSLVFEEKVFFIDCDVAIFKIIIEWMKTGecEKLSEKELKLVLRACEE 210
                 689999998887665553111368888888888667775699999999*********************55445555544444444444 PP

>> EF1_GNE  EF-1 guanine nucleotide exchange domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.2     4e-05      0.24       2      40 ..      57      95 ..      56     119 .. 0.88
   2 ?   -3.9   0.0       2.7   1.6e+04      18      30 ..     250     262 ..     247     265 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4e-05
                EEEEEEESSS---HHHHHHHHHH.HS-TSEE--.--EEE CS
     EF1_GNE  2 vvlevkPeddetdleelekkvksikleglvwgeasklep 40
                + l+v P  ++ dle l +++k+i+ e++++ +++kl++
  EFC36444.1 57 LKLNVEPHQQQDDLEILLNRLKEIEEEKCKIIQEFKLQE 95
                6899***************************99999987 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 2.7
                 H.HHHHHH.HS-TS CS
     EF1_GNE  18 l.ekkvksiklegl 30 
                 l ek+vks k +gl
  EFC36444.1 250 LfEKHVKS-KNDGL 262
                 44889999.88875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1200  (0.0669307); expected 358.6 (0.02)
Passed bias filter:                      623  (0.0347482); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.48
# Mc/sec: 2545.68
//
Query:       EFC36445.1  [L=536]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.2e-22   77.9   3.1    5.5e-05   23.0   0.1    5.7  5  NHL           NHL repeat
    6.8e-07   28.7   7.3     0.0037   16.5   0.0    3.6  4  DUF5128       6-bladed beta-propeller
    8.5e-06   25.5   0.0      0.029   14.0   0.0    3.6  3  SGL           SMP-30/Gluconolactonase/LRE-like region
     0.0012   19.0   0.0        2.3    8.5   0.0    3.2  3  Arylesterase  Arylesterase
     0.0052   16.8   1.4        5.1    7.2   0.0    3.7  5  SBBP          Beta-propeller repeat
  ------ inclusion threshold ------
       0.15   12.5   0.0         24    5.5   0.0    3.1  3  Ldl_recept_b  Low-density lipoprotein receptor repeat class B


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0   0.00054       1.6       1      28 []     277     305 ..     277     305 .. 0.91
   2 !   23.0   0.1   1.8e-08   5.5e-05       1      27 [.     368     394 ..     368     395 .. 0.97
   3 !   19.0   0.0   3.3e-07   0.00099       1      28 []     415     442 ..     415     442 .. 0.97
   4 !   20.0   0.1   1.7e-07   0.00049       1      28 []     462     490 ..     462     490 .. 0.97
   5 ?    2.6   0.0     0.053   1.6e+02       4      28 .]     508     535 ..     505     535 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00054
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 f  P ++ ++   + ++Va+++n  +q+F
  EFC36445.1 277 FDGPVDIKYLsRRDYLLVACYNNKNIQIF 305
                 7789999999889999************9 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 1.8e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 fn P+G +vd  G+i+V+D+ n+r++v
  EFC36445.1 368 FNGPTGMVVDEEGRIFVCDCLNSRIVV 394
                 99***********************98 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 3.3e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f +P+++++ds G+++++Ds++h +qv+
  EFC36445.1 415 FLMPWSITIDSFGNLLITDSGRHVIQVY 442
                 789***********************98 PP

  == domain 4  score: 20.0 bits;  conditional E-value: 1.7e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 fn P+ +++d  +G+++++D +n+r+q+F
  EFC36445.1 462 FNTPRAITIDqITGNVLICDEGNNRIQIF 490
                 8999******99****************9 PP

  == domain 5  score: 2.6 bits;  conditional E-value: 0.053
                 EEEEEEE.TTTEEEEEE..CCCTEEEEE CS
         NHL   4 PhGvavd.snGdiyVaD..senhrvqvF 28 
                 P+G+++d +   +yV++   e++ +q+F
  EFC36445.1 508 PTGLTLDpTRALLYVSEwdLEHNFIQIF 535
                 9999999999999999999999999998 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.2         1     3e+03     276     276 ..      62      62 ..       9     104 .. 0.54
   2 ?    0.7   0.1     0.079   2.4e+02      63      91 ..     290     319 ..     277     321 .. 0.75
   3 !   16.5   0.0   1.2e-06    0.0037      58     112 ..     375     429 ..     369     431 .. 0.91
   4 !   14.8   0.1   3.9e-06     0.012      64     127 ..     428     491 ..     427     505 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1
     DUF5128 276 k 276
                  
  EFC36445.1  62 L 62 
                 1 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.079
     DUF5128  63 krifvlDsaknnlfvFd.kkGkfvrkIgaq 91 
                 + ++v   +++n+ +Fd k+ +++++I+ q
  EFC36445.1 290 DYLLVACYNNKNIQIFDaKTLEYKYQISTQ 319
                 45666666778899***9999999999875 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 1.2e-06
     DUF5128  58 ikvvdkrifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnes 112
                 +++ ++rifv D  ++++ v +k+G+f +  g++G   g +l   +++id   + 
  EFC36445.1 375 VVDEEGRIFVCDCLNSRIVVLSKEGQFLYNFGEKGTKKGQFLMPWSITIDSFGNL 429
                 566679********************************************98765 PP

  == domain 4  score: 14.8 bits;  conditional E-value: 3.9e-06
     DUF5128  64 rifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknkiltYd 127
                  ++++Ds +  + v++ +G+  ++Ig++G+   E+     ++id+   ++ i d  +n+i +++
  EFC36445.1 428 NLLITDSGRHVIQVYSPNGEHLNEIGKKGSSKFEFNTPRAITIDQITGNVLICDEGNNRIQIFN 491
                 589********************************************************99987 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.0   9.7e-06     0.029     181     216 ..     367     401 ..     314     408 .. 0.87
   2 !    5.5   0.0    0.0037        11     186     220 ..     418     452 ..     403     460 .. 0.87
   3 ?    0.6   0.0      0.12   3.5e+02     118     151 ..     490     523 ..     478     528 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 9.7e-06
         SGL 181 kgegepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                 +++g p G++vD+eG+++v+   ++++v+++++G+ 
  EFC36445.1 367 QFNG-PTGMVVDEEGRIFVCDCLNSRIVVLSKEGQF 401
                 3344.99**************************986 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0037
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGklieei 220
                 p ++++D+ Gn+ ++  g + +++++p+G+ ++ei
  EFC36445.1 418 PWSITIDSFGNLLITDSGRHVIQVYSPNGEHLNEI 452
                 66899**************************9988 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.12
         SGL 118 yrldpdgklervlddltipNGlawspdgktlYla 151
                 +  +  ++++ + d+l+ p Gl ++p    lY+ 
  EFC36445.1 490 FNSTLTEHVKIIEDRLHAPTGLTLDPTRALLYVS 523
                 5555667899999*******************86 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.1   6.3e+03      53      81 ..     277     305 ..     273     309 .. 0.82
   2 !    6.8   0.0    0.0025       7.6      51      83 ..     366     397 ..     352     400 .. 0.87
   3 !    8.5   0.0   0.00077       2.3      45      73 ..     497     525 ..     462     535 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.1
  Arylesterase  53 lssanGInidadkkyiyvadilresihvm 81 
                   ++ +  I++ + + y+ va   +++i ++
    EFC36445.1 277 FDGPVDIKYLSRRDYLLVACYNNKNIQIF 305
                   77788899999999999999999998776 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0025
  Arylesterase  51 sglssanGInidadkkyiyvadilresihvmkk 83 
                   ++++ ++G+++d + + i+v d l+  i v+ k
    EFC36445.1 366 NQFNGPTGMVVDEEGR-IFVCDCLNSRIVVLSK 397
                   67999*******9998.8**********99887 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00077
  Arylesterase  45 evkvvasglssanGInidadkkyiyvadi 73 
                   +vk   ++l++++G+++d+ +  +yv++ 
    EFC36445.1 497 HVKIIEDRLHAPTGLTLDPTRALLYVSEW 525
                   57777899******************975 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.5       2.1   6.2e+03      32      38 .]       5      11 ..       4      11 .. 0.89
   2 ?   -3.1   0.0       2.8   8.5e+03      11      22 ..     318     329 ..     316     331 .. 0.79
   3 !    6.2   0.0    0.0034        10      15      29 ..     371     385 ..     371     385 .. 0.92
   4 !    7.2   0.0    0.0017       5.1      17      29 ..     420     432 ..     418     432 .. 0.92
   5 ?   -2.6   0.1         2   5.8e+03      14      22 ..     464     472 ..     464     479 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.1
        SBBP 32 Tngnnfe 38
                Tn++nf+
  EFC36445.1  5 TNSYNFN 11
                9****96 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 2.8
        SBBP  11 astygngIavDs 22 
                 ++ +++g+a D+
  EFC36445.1 318 TQSEIRGMALDP 329
                 5678999*9997 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0034
        SBBP  15 gngIavDsnGNiYvt 29 
                 ++g+ vD++G i+v+
  EFC36445.1 371 PTGMVVDEEGRIFVC 385
                 79***********95 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0017
        SBBP  17 gIavDsnGNiYvt 29 
                 +I++Ds+GN  +t
  EFC36445.1 420 SITIDSFGNLLIT 432
                 8********9987 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 2
        SBBP  14 ygngIavDs 22 
                 +++ I++D+
  EFC36445.1 464 TPRAITIDQ 472
                 588999994 PP

>> Ldl_recept_b  Low-density lipoprotein receptor repeat class B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       4.4   1.3e+04      32      41 ..     368     377 ..     364     378 .. 0.74
   2 ?    3.5   0.0     0.034     1e+02      32      41 ..     462     471 ..     432     472 .. 0.67
   3 ?    5.5   0.0    0.0081        24      25      42 .]     497     515 ..     489     515 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 4.4
                   -S-EEEEEEE CS
  Ldl_recept_b  32 lqnPrgiAvD 41 
                   ++ P+g +vD
    EFC36445.1 368 FNGPTGMVVD 377
                   7779999999 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.034
                   -S-EEEEEEE CS
  Ldl_recept_b  32 lqnPrgiAvD 41 
                   +++Pr+i++D
    EFC36445.1 462 FNTPRAITID 471
                   99*******9 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0081
                   EEEE-SS.-S-EEEEEEET CS
  Ldl_recept_b  25 ktlfqed.lqnPrgiAvDp 42 
                   ++++ ed l +P+g+++Dp
    EFC36445.1 497 HVKIIEDrLHAPTGLTLDP 515
                   66778888**********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (536 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1580  (0.0881254); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.74u 0.31s 00:00:01.05 Elapsed: 00:00:00.50
# Mc/sec: 3228.79
//
Query:       EFC36446.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.9e-09   35.7   0.0    3.2e-08   33.3   0.0    2.0  2  Pkinase      Protein kinase domain
      5e-05   22.7   0.0    8.2e-05   22.0   0.0    1.3  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.0   3.5e-12   3.2e-08      38     136 ..     158     250 ..     123     257 .. 0.83
   2 ?   -0.5   0.0     0.072   6.4e+02     175     204 ..     271     300 ..     260     319 .. 0.67

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 3.5e-12
                 CHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE CS
     Pkinase  38 kkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge 136
                 ++ +       i  l +l+ +niv++ ++    ++ +l + + + g+l++ll+r   +se+ + ++a+++l +l ++ +++i+ rD  p+NiL++++g 
  EFC36446.1 158 SSGD------DIYKLLSLRNSNIVEITHCGLIGKRPFLETKWYRDGTLDQLLKRGEFISENSLTRMASSLLDSLLFIQENNIVCRDFRPSNILVERHGA 250
                 4433......478888999***********************************99**************************************98775 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.072
                 SHHHHHHHHHHHHHHHHHSS-STTTSSHHH CS
     Pkinase 175 skkvDvWslGvilyelltgkppfsgekgke 204
                 s+k  + s+G il+ l+t+k   +++ ++e
  EFC36446.1 271 SQKRNIKSIGQILFMLMTRKSCINESITRE 300
                 667777788888888888888777555444 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0   9.2e-09   8.2e-05      55     139 ..     166     248 ..     155     253 .. 0.92

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 9.2e-09
                  HHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEET CS
  Pkinase_Tyr  55 mkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsen 139
                  + +l++ niv+++ + + +++ ++ t++ + G+L++ L++   e ++ ++l+++a  + + + +++++++v rd +  N+L++++
   EFC36446.1 166 LLSLRNSNIVEITHCGLIGKRPFLETKWYRDGTLDQLLKRG--EFISENSLTRMASSLLDSLLFIQENNIVCRDFRPSNILVERH 248
                  667899*********9999999*****************97..9**************************************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1083  (0.0604049); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 1992.73
//
Query:       EFC36447.1  [L=452]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.7e-22   78.5   0.1    7.7e-22   77.8   0.1    1.3  1  Pkinase_Tyr  Protein tyrosine kinase
    1.9e-16   60.2   0.1    3.3e-16   59.4   0.1    1.3  1  Pkinase      Protein kinase domain
    5.4e-09   35.9   0.1    5.4e-09   35.9   0.1    1.5  2  Nop          snoRNA binding domain, fibrillarin
  ------ inclusion threshold ------
      0.016   15.2   0.3       0.45   10.6   0.1    2.6  2  DUF3660      Receptor serine/threonine kinase
       0.13   12.1   0.0       0.33   10.8   0.0    1.7  1  PSD2         Protein of unknown function (DUF1585)


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.8   0.1   2.2e-25   7.7e-22       2     129 ..     192     315 ..     191     324 .. 0.91

  Alignments for each domain:
  == domain 1  score: 77.8 bits;  conditional E-value: 2.2e-25
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ek 97 
                  e+ +kl+eG  G V+ g+l       +++Va+K lk++ +    +e+ +ea+++++l+h+ni+ l g+c+ +e+ ++vte+++ G+L+k L +    +
   EFC36447.1 192 EIVRKLAEGGLGIVYLGKLV-----GKIDVAIKLLKSTDQG---DEFEQEASLLSSLRHDNILTLFGICVTSENKYMVTEFAEMGSLDKSLYRAriGE 281
                  7889****************.....99********766555...59*********************************************9994445 PP

                  TTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST- CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskk..lvHrdl 129
                   +l lk++ls+ +  AkG+eyL++ +  +vHrdl
   EFC36447.1 282 ITLPLKNKLSILIATAKGIEYLHNLTptVVHRDL 315
                  6677899****************97555*****9 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.4   0.1   9.2e-20   3.3e-16       2     124 ..     192     315 ..     191     317 .. 0.90

  Alignments for each domain:
  == domain 1  score: 59.4 bits;  conditional E-value: 9.2e-20
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS-- CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsls 96 
                 e ++kl eG+ G Vy ++    +  vA+K +k  ++ ++ e    +E ++l +l+h+ni++l++++ ++++ y+v+e++e g+l++ l      + +l+
  EFC36447.1 192 EIVRKLAEGGLGIVYLGK-LVGKIDVAIKLLKSTDQGDEFE----QEASLLSSLRHDNILTLFGICVTSENKYMVTEFAEMGSLDKSLYrariGEITLP 285
                 5689999***********.688899*********9999777....9*************************************9998886655556677 PP

                 HHHHHHHHHHHHHHHHHHHHTT..EE-SS- CS
     Pkinase  97 eeeakkiakqilegleylHskg..iiHrDl 124
                  ++  +i+  +++g+eylH+    ++HrDl
  EFC36447.1 286 LKNKLSILIATAKGIEYLHNLTptVVHRDL 315
                 778889*************87666*****9 PP

>> Nop  snoRNA binding domain, fibrillarin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       1.7     6e+03     172     181 ..     143     152 ..     122     178 .. 0.48
   2 !   35.9   0.1   1.5e-12   5.4e-09      58     139 ..     369     445 ..     320     450 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 1.7
                 CHHHCSHHHH CS
         Nop 172 Gliyhselvq 181
                  +i+++++v+
  EFC36447.1 143 KVIFQNSVVS 152
                 2333333333 PP

  == domain 2  score: 35.9 bits;  conditional E-value: 1.5e-12
                 HHHHHHHHHHHHCHHHH-SSS-S-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHCHHHHHHHHHHHHSSH CS
         Nop  58 eelakevimaakvtastsmgaelseedlknikelcdrvleleelrkelleYlesrmsaiAPNlsaLvGeevaarLishaGgL 139
                 ++l++++ + a      ++g+els+++l++i++l++++  l + ++++   l++rm  +AP + + +Ge v+ar+i++ G L
  EFC36447.1 369 DDLERKIRESAIS----TSGSELSDKELQEISKLAQQAEPLLTEKSKIRGALRERMILVAPRVYEKLGEVVGARMIQKFG-L 445
                 2277777777777....9***********************************************************998.5 PP

>> DUF3660  Receptor serine/threonine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.073   2.6e+02       3      21 ..      59      70 ..      57      75 .. 0.84
   2 ?   10.6   0.1   0.00012      0.45      12      41 ..     143     177 ..     139     177 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.073
     DUF3660  3 PiVdqvRsqdllmnevVis 21
                P       q + m++vVis
  EFC36447.1 59 P-------QMFTMDDVVIS 70
                5.......8899******8 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00012
     DUF3660  12 dllmnevVissrrylsgEnkt.....edLELPLmE 41 
                 ++++  +V+ss++ ls++ k+      dL +PL+E
  EFC36447.1 143 KVIFQNSVVSSQSTLSETAKSkqsnnSDLSVPLIE 177
                 578999***************9998889*****98 PP

>> PSD2  Protein of unknown function (DUF1585)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   9.2e-05      0.33      38      74 .]     324     360 ..     305     360 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 9.2e-05
        PSD2  38 gleasDrcaveeivaalrasgyrlrdlieaivtSdpF 74 
                 ++++sD++ + +  +++++ +  l++l+++iv+S+ F
  EFC36447.1 324 KMQDSDETFIIRNIQQYEEVDMPLSALLLQIVQSYGF 360
                 6899******************************988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (452 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       815  (0.0454571); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.50u 0.23s 00:00:00.73 Elapsed: 00:00:00.40
# Mc/sec: 3378.03
//
Query:       EFC36448.1  [L=2200]
Description: ribonuclease II family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-74  250.6   0.4    2.4e-74  250.6   0.4    2.6  2  RNB            RNB domain
    1.8e-11   43.9   0.0    5.2e-11   42.4   0.0    1.9  1  OB_Dis3        Dis3-like cold-shock domain 2 (CSD2)
    1.4e-09   38.1   0.1    6.5e-09   35.9   0.1    2.3  1  PAP_assoc      Cid1 family poly A polymerase
    1.8e-07   30.9   0.1    2.1e-06   27.5   0.1    2.5  2  Rrp44_CSD1     Rrp44-like cold shock domain
    2.1e-05   24.7   1.7    0.00025   21.3   0.0    2.9  2  NTP_transf_2   Nucleotidyltransferase domain
    0.00026   21.0   3.4     0.0014   18.6   0.1    3.6  2  Polbeta        Polymerase beta, Nucleotidyltransferase
     0.0043   17.3   0.0      0.039   14.3   0.0    2.8  1  Dis3l2_C_term  DIS3-like exonuclease 2 C terminal
  ------ inclusion threshold ------
      0.016   14.9   0.1      0.045   13.4   0.1    1.8  1  OB_RNB         Ribonuclease B OB domain


Domain annotation for each model (and alignments):
>> RNB  RNB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   1.2       1.7   3.9e+03     141     179 ..     639     682 ..     614     743 .. 0.55
   2 !  250.6   0.4   1.1e-77   2.4e-74       6     325 ..    1424    1866 ..    1419    1867 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.7
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxx RF
         RNB 141 ktaedLellyelakalrkkRlkkgalef.....dspeiklllde 179
                 k+++dL   +++a+a ++++++++ + +     ++ ++++ ++e
  EFC36448.1 639 KQKNDLASSSNVASASSSEKEESEVVAVasqitEKVQSQVAISE 682
                 34555555555555555555555444443322212222222222 PP

  == domain 2  score: 250.6 bits;  conditional E-value: 1.1e-77
                  xxxxxxxxxxxxxxxxxxxxxxxxx...............xx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         RNB    6 dllvitIdpedakdlDdAisieklp...............ng..nyelgVhIADvshyvkegspldkearkratsvyLpekvvpMLPqelsedlcSL 85  
                  +  ++tIdp +++dlDdAi ie++                 g  ++ ++V+IADvs++v+egsp+dkearkr+tsvy+ + v +ML ++ls++lcSL
  EFC36448.1 1424 SRRIFTIDPTESRDLDDAIAIEPILengqqlnndayrkpyAGvrKFLVTVAIADVSQFVPEGSPIDKEARKRGTSVYMVNSVEHMLDPSLSQNLCSL 1520
                  5689*****************632234444445555566745669**************************************************** PP

                  xxxxxxxxxxxxxxxxxx.xxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxx...........................xxxxxxxxxx RF
         RNB   86 npgedrlalsvlidvdek.gev..lsveiylsvIkskarltydevqdlleqkdeke.ekk...........................taedLellye 151 
                  + g +r  + v++ +d +  ++   s ++++++++s  rl+y+ +q+++   ++k  +++                           + ed++ ++e
  EFC36448.1 1521 HGGVNRFGVAVEFVIDREtATIekSSIKFNRCMMRSACRLDYNRAQKMIVHYKNKFfNGQnetdpkrryglepeevpavygsftldeIYEDVQIFNE 1617
                  *****************9777864556**********************877776666559************************************ PP

                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxx................ RF
         RNB  152 lakalrkkRlkkgalefdspeikllldedkg.nrielkveeetkahslveelmllANelvArfl.seleipailriheeps................ 230 
                  l+++lrk+R +kg++ +++++ +++ d d +  +++++  e++++h l+ee+ml+ANel+A++l  ++++ ++lr+h+ p+                
  EFC36448.1 1618 LSQKLRKQRADKGSIFLQNEQLRFECDMDGKgFPLKVACDEHNESHMLIEEMMLVANELAATVLnDHFGDATLLRVHSSPKvekwavtvslladkiy 1714
                  *****************877776666664433899999999999********************9999***************************** PP

                  ....................xxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxx......... RF
         RNB  231 ....................nekledliklakklglk.........lednsskknlqeslekleeee..aeqllselllrllkeakys......... 287 
                                          + l kl k               e+ ++ +n+ ++l +  +++   + +++++llr ++ a+y          
  EFC36448.1 1715 kwkldnvtrsgiaveaekekA---HVLDKLEKC---VkhvtkgaenNEKPITIQNIINLLIESTKDYptLMHTIQHSLLREMQLAQYAtvgdckkgk 1805
                  999999999999999995552...333333331...11223453334444444455555544444448********************999999999 PP

                  .......................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         RNB  288 .......................sepvgHfgLaleeYthfTSPirRYpDlvvhrllkalla 325 
                                          e++ Hf+L  e YthfTSPirRY+Dlvvhrll ++++
  EFC36448.1 1806 ettkeivveptdigskrmvpkkqFENTWHFALCKEFYTHFTSPIRRYADLVVHRLLLQMIR 1866
                  99999998888888888777666666******************************98876 PP

>> OB_Dis3  Dis3-like cold-shock domain 2 (CSD2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.4   0.0   2.3e-14   5.2e-11       1      76 [.    1253    1328 ..    1253    1329 .. 0.97

  Alignments for each domain:
  == domain 1  score: 42.4 bits;  conditional E-value: 2.3e-14
                  EEEE--SSTTS--EEEETTSSTTTHHHHTTTTTT--EEEEE----TT-SS-EEEEEEE-HHHHHHHHHHHHHHHHT CS
     OB_Dis3    1 yvlfkPldkrlPriliptkelpeeflenpeelegklfvvkidsWsetsryPlGeivksLGeagdieaeteaiLlen 76  
                  y ++ Pl+k +P++++p +e  ++f ++  +le  +fvv+++ W+++s++P+G i+ +LG   d+ +  +a+Ll++
  EFC36448.1 1253 YRWLLPLEKTYPKLNVPFEEFEKQFNAKSITLEEGIFVVEMKPWNKNSNFPKGAIIGCLGLKKDLWSLKRALLLQY 1328
                  67999********************************************************************986 PP

>> PAP_assoc  Cid1 family poly A polymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9   0.1   2.9e-12   6.5e-09       2      59 ..    1002    1048 ..    1001    1050 .. 0.90

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 2.9e-12
                  HHHHHHHHHHHHHHT--TTTEEEECSST-EEEHHHHCGCS-SSEECESSSSEBEETTC CS
   PAP_assoc    2 LGeLLigFFeyYgreFdyenvvisirtggiltkkekgwesaeskernrfllaIeDPfe 59  
                  LG L+  FFe+Y+++Fd++++ isir g  ++kk+ +             ++ eDPfe
  EFC36448.1 1002 LGHLIYLFFEFYAKKFDFDTNCISIRAGSPVPKKNAKTI-----------ISLEDPFE 1048
                  9********************************998877...........77777777 PP

>> Rrp44_CSD1  Rrp44-like cold shock domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.36     8e+02      49      74 ..     235     258 ..     224     295 .. 0.83
   2 !   27.5   0.1   9.6e-10   2.1e-06       5      70 ..    1109    1175 ..    1106    1235 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.36
                 EEESHHHHTS--TT-EEEEEE--GGG CS
  Rrp44_CSD1  49 livgqknlnrafngdqvivellpqse 74 
                 +i+ qk ++  ++gd+ i+ellpq +
  EFC36448.1 235 FILHQKGIK--VEGDDRIIELLPQFD 258
                 566666654..68**********975 PP

  == domain 2  score: 27.5 bits;  conditional E-value: 9.6e-10
                  -----HHHHHHHHHTTSEEEEEEEEESSBTT.EEEEE-SSSSS-EEEESHHHHTS--TT-EEEEEE- CS
  Rrp44_CSD1    5 peyystarvmgglkngvlyqgniqiseynfl.egsvslprfskpvlivgqknlnrafngdqvivell 70  
                   +y ++  v   l +g lyqg++++ +  f  e  vs+  f k vl+ g kn nra+ gd v +++ 
  EFC36448.1 1109 DDYLASEAVDEMLAKGELYQGELRVNKKRFTtEAYVSVEGFKKDVLVEGLKNRNRAMHGDVVAIKIQ 1175
                  57888888889999**************9964899*************************9988764 PP

>> NTP_transf_2  Nucleotidyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   1.0      0.34   7.6e+02      51      91 ..     323     365 ..     303     372 .. 0.71
   2 !   21.3   0.0   1.1e-07   0.00025      14      48 ..     764     818 ..     755     877 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.34
                   EHHHHHHHHCCCEEECTTEEEEEE...CEEECCCCTEEEEEECE CS
  NTP_transf_2  51 egleklaeiikfleellglevdlv...trekledpllvksilee 91 
                    +++k++ei+ ++++l+    dl+   +++++e  +l+k ++++
    EFC36448.1 323 IYAKKRKEIENEIDRLMEKSLDLIdlvEEAEKE-EKLSKRTMSS 365
                   46789999999999*999999999987444444.3444444433 PP

  == domain 2  score: 21.3 bits;  conditional E-value: 1.1e-07
                   TSEEEEEHHHHCTTSCTT.SSEEEEEEESTTCHHH...................H CS
  NTP_transf_2  14 vakvvlfGSyarGtalkg.SDiDllvvlpeevsre...................k 48 
                   + k++++GSya ++ lkg SDiD +v +    + +                   k
    EFC36448.1 764 PPKIYTYGSYASDLSLKGsSDIDMCVSFAGLENIQenskiqgrllemirkemdgK 818
                   569*************************999665555555555544444444440 PP

>> Polbeta  Polymerase beta, Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   1.0      0.43   9.6e+02      45      72 ..     325     352 ..     270     372 .. 0.81
   2 !   18.6   0.1   6.4e-07    0.0014      12      85 ..     763     836 ..     745     842 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.43
                 HHHHHHHHHHHHHH.SSSEEEEEETT.TS CS
     Polbeta  45 leeelelaaelediklgkkvDlvdln.ea 72 
                  +++ e+++e++++  +k++Dl+dl  ea
  EFC36448.1 325 AKKRKEIENEIDRL-MEKSLDLIDLVeEA 352
                 45678899999999.77888888865344 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 6.4e-07
                 HHHSTTEEEEEE.-S------EEEEEEEESS---HHHHHHHHHHHHHH.SSSEEEEEETTTS-HHHHHHHHHS-E CS
     Polbeta  12 eielaylFGSra.kgkareeSDiDlavllkekldleeelelaaelediklgkkvDlvdlneapplllyeilkegk 85 
                 +   +y +GS+a +  ++ +SDiD++v +   ++++e  +++  l ++ ++k++D    +++++l+ +   ++ +
  EFC36448.1 763 QPPKIYTYGSYAsDLSLKGSSDIDMCVSFAGLENIQENSKIQGRLLEM-IRKEMDGKSKKDTNTLFPHLKSQNQE 836
                 55689*******4556778****************************9.88999988877777777665555555 PP

>> Dis3l2_C_term  DIS3-like exonuclease 2 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   1.7e-05     0.039       6      32 ..    1935    1961 ..    1933    2048 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.7e-05
  Dis3l2_C_term    6 kavVvnVldssfDVlileyGlekRVyl 32  
                     +avV+++ ++sf+ ++++yGle  V  
     EFC36448.1 1935 EAVVLSMGKRSFTLFVPKYGLELQVNA 1961
                     8*********************99865 PP

>> OB_RNB  Ribonuclease B OB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1     2e-05     0.045       2      45 ..    1130    1177 ..    1129    1182 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2e-05
                  EEEE-SSS-...EEEEECT.TEEEEE-H.HHHTTS-TT-EEEEEEEES CS
      OB_RNB    2 tvrahkkGF...GFlipdegkeDifipp.eqmkkamhGDrVlvritkg 45  
                   +r +kk F   +++++++ k+D+ +   ++ ++amhGD V ++i+k+
  EFC36448.1 1130 ELRVNKKRFtteAYVSVEGFKKDVLVEGlKNRNRAMHGDVVAIKIQKT 1177
                  56777777777789************7538899************994 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1817  (0.101344); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.36u 0.33s 00:00:01.69 Elapsed: 00:00:00.54
# Mc/sec: 12327.84
//
Query:       EFC36449.1  [L=432]
Description: beta-amylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     4e-101  338.9   2.1   4.9e-101  338.6   2.1    1.0  1  Glyco_hydro_14  Glycosyl hydrolase family 14
    0.00012   21.8   0.0    0.00023   20.9   0.0    1.3  1  Glyco_hydro_35  Glycosyl hydrolases family 35


Domain annotation for each model (and alignments):
>> Glyco_hydro_14  Glycosyl hydrolase family 14
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  338.6   2.1  5.4e-105  4.9e-101       3     393 ..       1     415 [.       1     422 [. 0.91

  Alignments for each domain:
  == domain 1  score: 338.6 bits;  conditional E-value: 5.4e-105
  Glyco_hydro_14   3 maPldkitestdle...alekdlralkqnGveaitvdvwwGlvekdGdqqfdfsyykelaqavkkaGlklvviisthqcGGnvGddcniPlPswv 94 
                     m+Pl++++  + l+    + + l+ +kq G ++i++dvwwG +e   +qq++f+ y +l  + ++ Glk+ +++s+hqcG nvGd c iPlP w+
      EFC36449.1   1 MMPLNTVNSDGSLNnpeKIYDYLQRVKQVGTDGIMIDVWWGIIEP-SPQQYNFNAYMQLFTMCRQVGLKVEPVLSFHQCGTNVGDACYIPLPLWI 94 
                     89*****999999866678889*********************97.699********************************************** PP

  Glyco_hydro_14  95 lekkskd..elvfkdesGrankeals............Pllsgrt.ikeyselyasfaerfegyk..dviakiylsgGPaGelryPsytesdG.w 171
                      +   ++  e+ ++d+ G++++e+ls               ++rt  + y++++  f+++f +++  +vi  i ++ GPaGe+ryPsy+  d  w
      EFC36449.1  95 HQVVGDKnpEIFYTDQNGHRDREYLSlgvdsealfpsnDSRRNRTpLEMYEQVMIQFNATFSSFIkgGVIDTIEIGLGPAGEMRYPSYQLQDNmW 189
                     *987765589**********************9996665567777799****************9899********************998888* PP

  Glyco_hydro_14 172 syPgrGkfqayteyaksslrayvedkygsldkvnkawGtklisea..ainlPedgeqflrnG..tynseyGkdflewyqgvleehldligeaakk 262
                     s+Pg+G fq+y++y+ + l  +++     +++ +  wG  ++ +a  +   P ++ +f  n   +y s yGk+f+ wy ++l +h+d i+  a+ 
      EFC36449.1 190 SFPGIGAFQCYDRYMLQDLAKAAR----EVGHPE--WGKTGPANAgnYNSRPFETGFFSENTfdNYDSSYGKFFIGWYTAKLIQHGDAILGRARS 278
                     *******************99998....677777..*******99888999*******9996447****************************** PP

  Glyco_hydro_14 263 afdssfgvkigakiaGvhwqynnptishgaekaaGyyd......ysrllkkfkkadldltftclemkdkgeaPeys..lPetlvkqvaslanekG 349
                     +f  s   k+++kiaG+hw y   t sh+ae++aGyy+      y  ++k+fkk++++ +ftclemkd+ e+P  +   Pe lv    + a + G
      EFC36449.1 279 VFGQS--SKLATKIAGIHWWYY--TWSHAAELTAGYYNtihyngYIDIAKMFKKHNVEFQFTCLEMKDR-EQPSDCacGPEELVALTRESAFNLG 368
                     **998..9**************..*********************************************.888766578**************** PP

  Glyco_hydro_14 350 velnGenaler.gdseefkkveevatn..fsysGftllrlnkllfeg 393
                     ++  Genale+ g+  + ++++++ +    s s ft+lr+ + l+  
      EFC36449.1 369 LKYGGENALEIlGNYAANQQIAKQSISdgKSISSFTFLRMSDELMAS 415
                     **********835667889998877661245667*******998843 PP

>> Glyco_hydro_35  Glycosyl hydrolases family 35
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.0   2.6e-08   0.00023      23      76 ..      16      66 ..      13      71 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 2.6e-08
                    GGGHHHHHHHHHHCT-SEEEEE--HHHH-SCTTB---SGGG-CHHHHHHHHHCT CS
  Glyco_hydro_35 23 pelWedvlekvkalGlnaietYveWnlhepkegkydfeGaldlekFlklaqeag 76
                    pe+  d l++vk++G + i + v W++ ep++++y+f++  +l     +++++g
      EFC36449.1 16 PEKIYDYLQRVKQVGTDGIMIDVWWGIIEPSPQQYNFNAYMQLFT---MCRQVG 66
                    778899*******************************99887654...444445 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       311  (0.0173462); expected 358.6 (0.02)
Passed bias filter:                      255  (0.0142228); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2601.51
//
Query:       EFC36450.1  [L=533]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.038   13.9   0.0      0.086   12.7   0.0    1.6  1  MF_alpha_N  Mating factor alpha precursor N-terminus


Domain annotation for each model (and alignments):
>> MF_alpha_N  Mating factor alpha precursor N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   4.8e-06     0.086      15      50 ..       5      41 ..       1      54 [. 0.72

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.8e-06
  MF_alpha_N 15 ssalaapvstedee.eeaaevPaeAvigyldlegdnd 50
                +s+ aa++s+++++  e + +P eAvigy +l ++++
  EFC36450.1  5 TSTAAAATSRKQRDgYELLVIPLEAVIGYTNLLSKEN 41
                3344444444444459999***********9987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (533 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       936  (0.0522059); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3174.69
//
Query:       EFC36451.1  [L=573]
Description: RGS domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.5e-08   33.4   5.7      1e-07   32.2   5.7    1.7  1  RGS          Regulator of G protein signaling domain
     0.0079   15.0   0.2     0.0079   15.0   0.2    2.5  3  DUF2207      Predicted membrane protein (DUF2207)
  ------ inclusion threshold ------
      0.013   15.8   3.2        1.3    9.3   0.9    2.6  2  DUF4064      Protein of unknown function (DUF4064)
        1.4    8.7   7.8       0.55   10.0   1.4    2.2  2  DUF443       Protein of unknown function (DUF443)
        8.8    6.5   9.1       0.55   10.4   0.6    3.0  4  Spore_GerAC  Spore germination B3/ GerAC like, C-terminal


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.2   5.7   2.9e-11     1e-07       4     117 ..     409     557 ..     406     558 .. 0.93

  Alignments for each domain:
  == domain 1  score: 32.2 bits;  conditional E-value: 2.9e-11
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..............................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkka..............................keqeelkkkakeIyneylapsspkelnidkkl 72 
                 + l+d++++ lFr+ +e+e + e ++F++++  +k+                               + +++  + a+eI+ e+++++ +k l + ++l
  EFC36451.1 409 DTLQDHALKALFRKHCETERCLESFEFLEKIHYYKEFcndsfdiqvklydsshptqtekkslesdlkEVEQKKYEVAFEIFTEFIDEHGEKALVVTSHL 507
                 6799***********************************************************9986555666666*********************** PP

                 HHHHHHHHCSS......STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS  73 reelekrleke......qpsrklfeeaqeevfellekdsypkFlkselylr 117
                  e ++ +l +       + s +lf+++q+ev  +l  d++ +F +s  +++
  EFC36451.1 508 CEDVKMKLDHFntgqsdHLSDELFDKLQTEVAIHL-LDCHARFKQSIAFQK 557
                 *******999899999999************9999.589999999999985 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.3      0.96   3.4e+03     144     195 ..      23      77 ..      10      90 .. 0.61
   2 ?    1.8   0.5     0.022        80     367     430 ..     158     213 ..     115     263 .. 0.49
   3 !   15.0   0.2   2.2e-06    0.0079     313     408 ..     300     387 ..     247     433 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 0.96
     DUF2207 144 sttvkkddgsvtftarnlppgeglevrvlfpt.n..narktsgnkldeilkeeqk 195
                 +t++ ++ ++  +t++n +p+  +   + ++  +   ++ + +++ + i+++e++
  EFC36451.1  23 TTERMNSPQQMSLTVNNNQPQASVSTQCEIELaDikDNQISPNSAEEHIKSSETR 77 
                 3333333444588888888888888888883343544555555555556666655 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.022
     DUF2207 367 kergyfdkkgkkkl.kklsalglgliilglilillallllvlllvfllilllillliaiivlllf 430
                 k+ + +++k  +k+ k+++ ++++ ++  + l+++ +l++         l++++ +ia++++++ 
  EFC36451.1 158 KTVNSYQSKATSKTsKTSGGFSVATCCGTVELNCIRVLSI---------LGMMINIIAFVAMAVV 213
                 2222233333333303333333333333333333222222.........2222222222211111 PP

  == domain 3  score: 15.0 bits;  conditional E-value: 2.2e-06
     DUF2207 313 eeldpyEkalldlLfdkseegkslkeikkyakkskkkakkfkkalkkwksavkk..kergyfdkkgkkklkklsalglgliilglilillallllvll 408
                  +++pyE+++++lL++++          ++   +  + k++ +    wk+ v +  ++ + + ++++ +l ++s ++ gli ++++l++ ++l+++++
  EFC36451.1 300 IPVNPYEQQVVNLLKSGK----------QKEAITLIESKNYTSYSLGWKNVVSNllTYAKELARNKNDYLLTSSSVNMGLIGFSILLVVPIVLAIFIM 387
                 3459**********9332..........2223333499999999999999999999999999999999999999999999999999999888876654 PP

>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.9   0.00037       1.3       6      52 ..     193     244 ..     190     255 .. 0.76
   2 ?    5.7   0.1    0.0049        17       8      37 ..     367     396 ..     342     418 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00037
     DUF4064   6 iiLglIGgilgillglllllflfllssgefsqeltee.....qalsgedasa 52 
                  +L+++G+ ++i++++++++++++  s ++++e +        +l+ e+a++
  EFC36451.1 193 RVLSILGMMINIIAFVAMAVVISVAFSVSTTNETELLilradANLMSEVAAS 244
                 69*******************9999888877765544666665555555554 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0049
     DUF4064   8 LglIGgilgillglllllflfllssgefsq 37 
                 +glIG+++ ++  ++l++f+  ++++  sq
  EFC36451.1 367 MGLIGFSILLVVPIVLAIFIMAINREGVSQ 396
                 678888666666666655554444444333 PP

>> DUF443  Protein of unknown function (DUF443)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   1.4   0.00015      0.55      37     121 ..     143     228 ..     141     248 .. 0.74
   2 ?    2.1   0.6     0.041   1.5e+02      55     124 ..     326     397 ..     309     421 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00015
      DUF443  37 kkvykiskeeieeklk.lnivkkakkksigllalGsavllgnllrklidvfniqlsklvnliillivlllvlvlriyiskklkkkl 121
                 k v+ i++ee +   k +n+ +++ +++++++  G++v+    + +l  +    +  +++ ii+++++++v+++ + +s+ ++ +l
  EFC36451.1 143 KSVTMITQEEQAFDTKtVNSYQSKATSKTSKTSGGFSVATCCGTVELNCIRVLSILGMMINIIAFVAMAVVISVAFSVSTTNETEL 228
                 56777777775443331566666667777777778877766555555555555667899999*****************9988776 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.041
      DUF443  55 ivkkakkksigllalGsavl.lg.nllrklidvfniqlsklvnliillivlllvlvlriyiskklkkklyne 124
                 ++k+ ++ s g++ + s +l  +  l+r+  d++   +s ++ li + i+l++ +vl i+i   +++ + ++
  EFC36451.1 326 ESKNYTSYSLGWKNVVSNLLtYAkELARNKNDYLLTSSSVNMGLIGFSILLVVPIVLAIFIMAINREGVSQK 397
                 555555556666555442221221577788888888888877777666666666666666655555555444 PP

>> Spore_GerAC  Spore germination B3/ GerAC like, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.6   0.00015      0.55      46     120 ..      16      95 ..       2      97 .. 0.78
   2 ?   -0.8   0.1      0.44   1.6e+03       5      41 ..     128     164 ..     124     190 .. 0.69
   3 ?   -3.5   0.0       3.1   1.1e+04      17      38 ..     304     325 ..     290     346 .. 0.58
   4 ?   -0.5   0.1      0.34   1.2e+03      68     137 ..     449     467 ..     408     539 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00015
                  E......EEEEEEE.EEEEEEE-SSSEEEEEEEEEEEEEE-----.-----HHHHHHHHHHHHHHHHHHHHHHHHTT--- CS
  Spore_GerAC  46 k.....vsveissskskikvkiengkpsfdikiklegdieeskknlleeeelkelekalekeiekeieealkklqeyksD 120
                  +      ++e+ +s  +++++++n++p+ +++ + e ++++ k+n ++ +  +e  k  e +  +++ ++l ++ e ++D
   EFC36451.1  16 SttsetTTTERMNSPQQMSLTVNNNQPQASVSTQCEIELADIKDNQISPNSAEEHIKSSETRTPSDCDDVLSTTAEVNFD 95 
                  134555689999999********************999997446767777788888888888888888888888888777 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.44
                  EEETTEEEE.E-HHHHHHHHHHTT-----EEEEE.ET CS
  Spore_GerAC   5 vFkkgklvgwLdeeetrgllllrgkvksgvitiplpk 41 
                  +++++klv +L+++   + ++ +++    + t++  +
   EFC36451.1 128 LISDDKLVKKLPNNSKSVTMITQEEQAFDTKTVNSYQ 164
                  6777799999999888888888877655555554333 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 3.1
                  HHHHHHHHHHTT-----EEEEE CS
  Spore_GerAC  17 eeetrgllllrgkvksgvitip 38 
                  + e ++++ll+   ++  it+ 
   EFC36451.1 304 PYEQQVVNLLKSGKQKEAITLI 325
                  5556666666633333333332 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.34
                  EEEEEEEEEEEEE-----.-----HHHHHHHHHHHHHHHHHHHHHHHHTT----S-HHHHHHHH.-HHHH.H CS
  Spore_GerAC  68 sfdikiklegdieeskknlleeeelkelekalekeiekeieealkklqeyksDilgfgeylrrk.hpkew.k 137
                  sfdi++kl                                                       + hp +  k
   EFC36451.1 449 SFDIQVKLYD-----------------------------------------------------SsHPTQTeK 467
                  3344444443.....................................................333332211 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1563  (0.0871772); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 3492.38
//
Query:       EFC36452.1  [L=1179]
Description: hypothetical protein NAEGRDRAFT_60001 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.9e-11   43.0   0.1    2.5e-10   40.7   0.1    2.4  1  RNase_H    RNase H
    2.2e-05   24.7   5.8    0.00013   22.3   0.2    3.7  3  UPF0223    Uncharacterised protein family (UPF0223)
  ------ inclusion threshold ------
       0.99    9.4   9.8       0.25   11.3   5.7    2.2  2  Rootletin  Ciliary rootlet component, centrosome cohesion
        2.1    8.4   5.3       0.33   11.0   0.2    2.4  3  HTH_19     Helix-turn-helix domain


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.7   0.1   5.5e-14   2.5e-10       5     141 ..     857     981 ..     853     983 .. 0.76

  Alignments for each domain:
  == domain 1  score: 40.7 bits;  conditional E-value: 5.5e-14
                 EEEEEEEEECTTTCEEEEE.EE.CTT......EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSB CS
     RNase_H   5 vvYtDGsclgnpgeggaga.vl.ykeg....arnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkp 97 
                  ++tDGs l  +++ g+g+ ++  + +     r +s +++++ +nn aE++ +i+a k   +d+k++i tDS+ +++ +++         ++ + ++ p
  EFC36452.1 857 DIHTDGSRL--ESKTGMGInIYdCS-NmntpVRSLSLHINDQYSNNVAEICSIITAAKVIPRDSKIKIHTDSNVAIE-VLK---------ERYKGNFLP 942
                 589****66..67777888444222.24434447777777999***************989***********99999.555.........223445556 PP

                 HTTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHH CS
     RNase_H  98 vknkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkea 141
                 +k+   ++++    +k + ++k+v++H+    +N  +D lAk+a
  EFC36452.1 943 LKK-AFFKTI--KDRKLEYEFKKVEAHKDK--ENIKVDLLAKNA 981
                 777.555555..2558899*********98..8*********98 PP

>> UPF0223  Uncharacterised protein family (UPF0223)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.2   2.8e-08   0.00013       5      84 ..     255     336 ..     253     338 .. 0.93
   2 ?    2.1   0.0     0.057   2.5e+02      43      83 ..     357     397 ..     349     400 .. 0.88
   3 ?    0.1   0.3      0.23     1e+03      47      78 ..     681     712 ..     655     719 .. 0.72

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 2.8e-08
                 -------HHHHHHHHHHHHHHHHHH..TT-EEHHHHHHHHHHHHHH---HHHHHHHHHHHHCCSS--HHHHHHHHHH---SE CS
     UPF0223   5 PldldwsteeiidVveffeavekay..ekgvereellkaYrrFkevvpskseekqldreFekasgyslYrvvkkakesekkk 84 
                 Pl l+ +t   ++ ++++e++ + y  e +++ eel ++Y + + +++   e+++++++  ++ g++ Y+++ ++++++k++
  EFC36452.1 255 PLALSHTTSSKTTHLKMLENIISKYilEDNISVEELYTNYSHNQFIIRISFEDQTICSQMAQNLGLNQYKTIEQIRNETKET 336
                 8999999999999999999999888668*************************************************99876 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.057
                 HHHHHH---HHHHHHHHHHHHCCSS--HHHHHHHHHH---S CS
     UPF0223  43 rrFkevvpskseekqldreFekasgyslYrvvkkakesekk 83 
                 ++F ++ +  +e++    + +++sg   Y+ +k ++++ ++
  EFC36452.1 357 QAFTRINKTLQENNLTITDTTNRSGTTKYKLIKIVHNDMDE 397
                 689999999999999999***************99887665 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.23
                 HH---HHHHHHHHHHHHCCSS--HHHHHHHHH CS
     UPF0223  47 evvpskseekqldreFekasgyslYrvvkkak 78 
                 ++ + k  + +l +eF++++  ++Y+  + ++
  EFC36452.1 681 HIKNGKHIKEKLIEEFNDRTSSKMYQFDRMVH 712
                 5788899999999***********99766555 PP

>> Rootletin  Ciliary rootlet component, centrosome cohesion
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.1       2.8   1.2e+04     130     144 ..      31      45 ..      26      48 .. 0.61
   2 ?   11.3   5.7   5.6e-05      0.25      34     145 ..     617     734 ..     598     742 .. 0.75

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 2.8
   Rootletin 130 kewreeeeafneyls 144
                 k++++e++++++yl+
  EFC36452.1  31 KTYQKENNNLRDYLQ 45 
                 456666666666665 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 5.6e-05
   Rootletin  34 eleqrllektselektkltlllssareleeeesadl.eealakLeeErqrseklaqvnslLre.qleearqaneaLted.lqkltkdwerlreeleqke 129
                 el+q +l++  + ++++ +l   + ++  +ee++dl ee+l+kL++E    ++++++ +lL+e ++++ ++  e+L e+ ++++++++ +    +++ke
  EFC36452.1 617 ELNQAILTQINKYGSKTDRLGVGRISTAYKEEIQDLeEEILHKLNNETISQSEISELQTLLKEtHIKNGKHIKEKLIEEfNDRTSSKMYQFDRMVHSKE 715
                 444444443333333333333344566677888888789**********************9846788888999998883579999************* PP

   Rootletin 130 kewre...eeeafneylss 145
                  +w++   eee++ ey+++
  EFC36452.1 716 IKWKDinfEEEEILEYFTN 734
                 ***9755577777777776 PP

>> HTH_19  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1       3.1   1.4e+04      46      61 ..     277     292 ..     270     294 .. 0.59
   2 ?   -3.2   0.1       2.1   9.2e+03      17      38 ..     313     335 ..     312     338 .. 0.62
   3 ?   11.0   0.2   7.4e-05      0.33       3      38 ..     361     396 ..     360     408 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 3.1
      HTH_19  46 lkiaealgidleyllq 61 
                  k+  + +i++e+l +
  EFC36452.1 277 SKYILEDNISVEELYT 292
                 4555566666666655 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.1
      HTH_19  17 elaerlgis.rskisaiEngkkd 38 
                 ++a++lg +  + i +i n+ k+
  EFC36452.1 313 QMAQNLGLNqYKTIEQIRNETKE 335
                 68888888755556666665554 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 7.4e-05
      HTH_19   3 rLkeaReelgltqeelaerlgisrskisaiEngkkd 38 
                 r+++   e++lt+ +  +r g++++k+++i ++ +d
  EFC36452.1 361 RINKTLQENNLTITDTTNRSGTTKYKLIKIVHNDMD 396
                 89******************************9776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1502  (0.0837749); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.85u 0.32s 00:00:01.17 Elapsed: 00:00:00.50
# Mc/sec: 7143.63
//
Query:       EFC36453.1  [L=100]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (100 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       639  (0.0356406); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.30s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 643.10
//
Query:       EFC36454.1  [L=846]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.5e-33  113.7   0.0    4.5e-27   95.0   0.0    2.2  2  Aminotran_5      Aminotransferase class-V
    3.7e-07   29.6   0.5    5.7e-05   22.5   0.5    2.3  1  Aminotran_1_2    Aminotransferase class I and II
  ------ inclusion threshold ------
      0.044   12.3   0.0      0.073   11.6   0.0    1.2  1  Cys_Met_Meta_PP  Cys/Met metabolism PLP-dependent enzyme


Domain annotation for each model (and alignments):
>> Aminotran_5  Aminotransferase class-V
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.1   6.3e-07    0.0038       2     101 ..     207     306 ..     206     331 .. 0.84
   2 !   95.0   0.0   7.6e-31   4.5e-27      91     344 ..     334     602 ..     325     613 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 6.3e-07
                  EEBTTTS----HHHHHHHHHHHHCTCCSSSSSSSHHHHHHHHHHHHHHHHHHHHHT-STGGGEEEESSHHHHHHHHHHHCCCC-TTTSEEEEETTSHG CS
  Aminotran_5   2 yldsaAttqkpqeVldalqeyytdynanvhrsvhhlgkeatkaveearekvaelinaeseeeiiftsGtteainlvalslarslkpgdeivvteaehh 99 
                  y d+ At +  + + d + e+    +an+h++++  g ++t+ +e+ar+ +a+ +na+ ++  +  s +t + +++ +  ++++k++de v+  a+  
   EFC36454.1 207 YCDYIATGKPLKMIEDYILEQVLPTYANTHNTTSFTGYQTTHLIEDARQIIAQCVNANLKKPEVASSTCTVSGECASQESNNTQKEDDEDVIIFAGSG 304
                  667777777777777888999999***********************************999999999999*********999888887666555544 PP

                  GG CS
  Aminotran_5 100 an 101
                  ++
   EFC36454.1 305 SA 306
                  44 PP

  == domain 2  score: 95.0 bits;  conditional E-value: 7.6e-31
                  EEEETTSHGGGTHHHHHHHHHHTEEEEEEEBETTSCBEGGGHHHH-.....-TTEEEEEEESBETTTTEB--HHHHHHHHHHTT-EEEEE-TTTTTTS CS
  Aminotran_5  91 ivvteaehhanlvpwqelakrtgakvkvipldeegeldldelekll.....nektklvaithvsnvtGtiqpveeigklakkkgalvlvDaaqavghi 183
                  ++++++ehh+n+++w+e     ga v  i  d+ g++dldel  +l     + ++ +v++t++snvtG++ ++e+i+kla++++a+ + D a +++  
   EFC36454.1 334 VIISTLEHHSNILAWRET----GACVIQIMEDKYGNVDLDELLIHLkqfkdSGRMLIVSMTAASNVTGVVTDTEAIAKLAHENNAWCFFDYAGGAPYL 427
                  89*************987....5778888899**********99998887778999****************************************99 PP

                  ---HHH.....HTESEEEEETTT.TTSSTT-EEEEEEHHHHHTS..SS.STTSEEEEETTEEEEHCTTGGGS.SS--HHHHHHHHHHHHHHHCHHHHH CS
  Aminotran_5 184 pidvkk.....lgvDflafsghK.llgPtGiGvlyvrkellekleplllggemveevsleettfaeapskfeaGTpnvagiiglgaaleyleeiglea 275
                   i+v+      l  D +++s hK + gP+  Gvl+++k+l  +  p ++gg+   +v+++++ +     k e+GT n++g i +++++++ +e+g + 
   EFC36454.1 428 DINVNPkndplLAKDAVFISPHKfIGGPSTPGVLIAKKKLFSNTVPSQPGGG---TVTYNHSYTPVVEEKEEGGTSNIIGSIRCALVFKLKDEVGPKL 522
                  99998533444778*********8889*************************...7888666668889999*************************** PP

                  HHHHHHHHHHHHHHHHCTSTTEEEES.......-B-CTCBSEEEEEETT....CSHHHHHHHHHHT.TEEEEEE-TTTHH CS
  Aminotran_5 276 iekhekelaeyllerlkslpgvrlygp......dkaerrasivsfnfkg....vhaedvatlLdee.gIavrsGhhcaqp 344
                  i++ e++ ++++l++ +  p++ ++gp      + + ++ + +sf +k     +h++ v  lL++  g   r G +ca p
   EFC36454.1 523 IQRIEEKYRDRALKTWSTNPNLVMVGPgldcigEGKVEKLAFFSFLVKHedyfLHPSYVSLLLNDLfGLQSRPGCSCAGP 602
                  ***************99999988866511111123445555566655432333455666666666666666666666666 PP

>> Aminotran_1_2  Aminotransferase class I and II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.5   9.5e-09   5.7e-05      27     189 ..     232     421 ..     211     425 .. 0.66

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 9.5e-09
                    HHHHHHHHTSTTST-BTTHHHHHHHHHHHHHC...TCT.....................TCHTTGGEGEEEESHHHHHHHHHHHHHH......... CS
  Aminotran_1_2  27 ekegalaggtlneygpidglpeleealakflg...rse.....................klklkreaavvvgsGagaliealifllk......... 89 
                     +   + + +++ y+++++  ++++ +a+ ++   +++                     +++ + ++ +  gsG+ a+i++li  +          
     EFC36454.1 232 YAN-THNTTSFTGYQTTHLIEDARQIIAQCVNanlKKPevasstctvsgecasqesnntQKEDDEDVIIFAGSGSAACINTLIHYIGirqkvreap 326
                    555.56677788888888888888888888884442223444455555555555555434444444444456666666666666665556666543 PP

                    .HTTT-EEEEEESS-THHHHHHHHTTSEEEEEEBEETTTTEE-HHHHHHHHTTHHCTTETEEEEEEESS-TTT--B--HHHHHHHHHHHHHTTEEE CS
  Aminotran_1_2  90 .lnpgdeilvpdptyasyknilrlsggevvryplyseedfhldlealeealkeapegnkktkvilvesphNPtGtvatleeleklldlakkynlll 184
                          +++++++ + s + ++r  g+ v+++   + +  ++dl++l+  lk+++       ++  + ++N tG+v + e + kl   a+++n++ 
     EFC36454.1 327 sEKELPVVIISTLEHHSNILAWRETGACVIQIM--EDKYGNVDLDELLIHLKQFKDSGR-MLIVSMTAASNVTGVVTDTEAIAKL---AHENNAWC 416
                    222222356666666555555555555555555..66999************9876666.889999*******************...******** PP

                    EEEET CS
  Aminotran_1_2 185 fvDea 189
                    f+D a
     EFC36454.1 417 FFDYA 421
                    ***65 PP

>> Cys_Met_Meta_PP  Cys/Met metabolism PLP-dependent enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   1.2e-05     0.073     140     215 ..     386     465 ..     359     488 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.2e-05
                      EEEEESS-TTTT----HHHHHHHHHHTT-EEEEEGTTTHTTT...S-GGG...GT-SEEEEETTTTTTCSSS--EEEEEESS CS
  Cys_Met_Meta_PP 140 lvylEtptnpllkvvDiekiaklakkagvlvvvDntfaspll...qrplk...lgaDivvhSaTKylgGhsdvvaGvivvkg 215
                      +v + + +n +  v+D e+iakla+++++  + D +  +p+l   ++p +   l  D v  S  K++gG s+   Gv+++k+
       EFC36454.1 386 IVSMTAASNVTGVVTDTEAIAKLAHENNAWCFFDYAGGAPYLdinVNPKNdplLAKDAVFISPHKFIGGPST--PGVLIAKK 465
                      56677889********************************8632255543443679*************987..47777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (846 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       792  (0.0441742); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.82u 0.31s 00:00:01.12 Elapsed: 00:00:00.50
# Mc/sec: 5058.52
//
Query:       EFC36455.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00089   18.3   0.0     0.0014   17.6   0.0    1.2  1  mTERF     mTERF
     0.0056   16.8   1.7     0.0056   16.8   1.7    1.8  2  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> mTERF  mTERF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   1.6e-07    0.0014     139     220 ..     211     293 ..     186     295 .. 0.92

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.6e-07
       mTERF 139 kkvkpkeieekVevlkelglskedvwkilkkyPeiLals.ekklkkkiefLkklglseeellrvikkyPqilslseekilksv 220
                  ++k++++ + V+++++++l + dv ++ ++ P+i+++   + l++++  L + ++++e+   ++     i++l  ++i+ ++
  EFC36455.1 211 GELKNENLARTVSFVEQFSLGEMDVLRLASRLPFIFEFIcGNALASQLVNLLQQNITKENCHDIVSTGSDIVKLCISNIRARI 293
                 5789999**************************************************************99999877777766 PP

>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   1.7   6.2e-07    0.0056      15      38 ..       5      27 ..       4      28 .. 0.91
   2 ?   -3.4   0.1       1.2   1.1e+04      22      31 ..     144     155 ..     143     159 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 6.2e-07
                TSSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus 15 akkPaCsnCkklnleCtfysessk 38
                ++kPaC +C ++++eC  y+e++k
  EFC36455.1  5 KNKPACERCTSRGVECI-YREPKK 27
                589**************.999876 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.2
                 HHHHCT..HHHC CS
     Zn_clus  22 nCkkln..leCt 31 
                 +C kln   eC 
  EFC36455.1 144 SCGKLNlaEECG 155
                 688888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       529  (0.0295053); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2845.91
//
Query:       EFC36456.1  [L=836]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-07   31.8   4.9    4.1e-07   30.3   4.9    1.9  1  RGS         Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.081   12.9   0.6        0.2   11.6   0.1    1.9  2  Hemopexin   Hemopexin


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   4.9   4.6e-11   4.1e-07       2      83 ..     665     744 ..     664     806 .. 0.85

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 4.6e-11
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke 83 
                 leslled++ r++F+++ ++efs en+ ++++ e+++k+  ++ ++++ k++++++l+  + +e+n ++ ++++ ++ +   
  EFC36456.1 665 LESLLEDETFREIFKSYSKNEFSMENILLYEELERLRKQ--RKCTLQDLKNLFETFLSATAVHEVNFPSGIKKSYQEIMDSY 744
                 89*************************************..89999**************************9999988764 PP

>> Hemopexin  Hemopexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       1.3   1.2e+04      15      26 ..     296     307 ..     295     313 .. 0.81
   2 ?   11.6   0.1   2.3e-05       0.2       9      26 ..     575     593 ..     570     600 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 1.3
                 EETTEEEEEETT CS
   Hemopexin  15 FkGdkYWrfdpq 26 
                 F++ k+ +f+p+
  EFC36456.1 296 FSDGKFRKFNPN 307
                 999999999987 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 2.3e-05
                 T.TEEEEEETTEEEEEETT CS
   Hemopexin   9 d.gktYFFkGdkYWrfdpq 26 
                   g+++FF + +Y+r d  
  EFC36456.1 575 GiGYFFFFDDPFYYRIDLL 593
                 259************9965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (836 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1477  (0.0823805); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.30s 00:00:01.07 Elapsed: 00:00:00.49
# Mc/sec: 5092.92
//
Query:       EFC36457.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.2e-18   64.9   6.8    1.1e-17   63.6   6.8    1.6  1  Mem_trans  Membrane transport protein
  ------ inclusion threshold ------
      0.074   13.3   0.2       0.25   11.7   0.2    1.8  1  DUF3382    Domain of unknown function (DUF3382)
        4.4    7.2   6.6       0.52   10.2   0.4    2.2  2  GP41       Retroviral envelope protein


Domain annotation for each model (and alignments):
>> Mem_trans  Membrane transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.6   6.8   1.8e-21   1.1e-17     126     386 ..      13     329 ..       6     330 .. 0.79

  Alignments for each domain:
  == domain 1  score: 63.6 bits;  conditional E-value: 1.8e-21
   Mem_trans 126 lmvqvvvlqciiiytlllflfeyrgaklliseefp.dtaasivsikvdsd...vvsldgrk..pleteaeikedgklhvtvrksnasrsdivssstprp 218
                  ++++ +   ++ yt++++ f++ +a+l++ +e++ ++  +++ i  +sd   +v l  ++   +e++++ + d++ hv+   + +s++    ++ pr 
  EFC36457.1  13 SLSVFIIPIEFVFYTVGYNSFKSGAARLKKLAEEEsNKKLESNDIINESDgtiEVELVDEEhpIVEEQNKEEIDEEHHVNQELIIESQQPN--QELPRL 109
                 4445555567999***********9999877666654444444444444322244454444324455555555777888777777666554..5589** PP

   Mem_trans 219 snltnaeiyslqmtrlilimvlrklirnPntyssllglilslvsfkwnvimp......kiiqksisilgdaglpmalfslGlfLalqpkkiacgnsvat 311
                 s l   + y  + + +i  + l++ +++P+++s+++++ ++l+s+ ++++++      + +++ +++ ++a +p+al++lG++L  +   ++ +n++  
  EFC36457.1 110 STLQKLKLYFYNNLENI--KELLRNLLSPPLISIFVAILIALISPVKDFLITdppmfiSSVKNICKVFSQAVSPAALIILGGNLGMTL--LKEENETLS 204
                 ************99999..8899****************************9*******************************98664..333444433 PP

   Mem_trans 312 fa..........................................lavRlilgPlvmlvavla.vgLr......gslllvaivqaAlPqgivlfviAkey 361
                 ++                                          l+ +li+ Pl+++++v+a ++L+        l+lv+++q+++P ++ l+ + ++ 
  EFC36457.1 205 NNidtnedetnllkriwikmkatligilkifkikkihplaiaisLITKLIIFPLIGVGLVYAgIYLKilptndPLLILVILIQFSMPMAMSLTSLSSLS 303
                 3346778***************************************************9986556542222224488999999************9975 PP

   Mem_trans 362 n.vherelstllifgmlialpitlvy 386
                 n ++++ + +ll++ +l++ ++++++
  EFC36457.1 304 NdFGQEQVCELLLWHYLLCPLSLSLF 329
                 5389999*************999986 PP

>> DUF3382  Domain of unknown function (DUF3382)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.2   4.1e-05      0.25       6      48 ..     244     286 ..     242     309 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.1e-05
     DUF3382   6 AliaallalvlfvpilGlqleldgtrlvleprwglvaiavavv 48 
                 A+  +l++ ++++p++G+ l+  g+ l + p+ + ++i+v+++
  EFC36457.1 244 AIAISLITKLIIFPLIGVGLVYAGIYLKILPTNDPLLILVILI 286
                 677799*************************999999988765 PP

>> GP41  Retroviral envelope protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.4   8.7e-05      0.52     106     180 ..      88     171 ..      72     180 .. 0.67
   2 ?   -0.7   1.1      0.19   1.1e+03     137     173 ..     210     245 ..     196     287 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 8.7e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHH..HHHH....HHHHHCHHHHHHHHHHHX..........XXXX....... CS
        GP41 106 laelhnliediqnqqektldeldkldklaqslanwfkllnslWvky....ivvilvglrivlivlsll..........Pvvfrslakel 180
                 ++++++++   ++q+++ l  l +l+kl+  ++n+++ ++ l ++     ++ i v+++i+li               P+ f s +k++
  EFC36457.1  88 EHHVNQELIIESQQPNQELPRLSTLQKLKLYFYNNLENIKELLRNLlsppLISIFVAILIALI----SpvkdflitdpPM-FISSVKNI 171
                 345556655566789999999*******************9*999855555555555555444....3223344567444.44555554 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.19
                 HHHHHHHHH..HHHHHHHHHCHHHHHHHHHHHXXXXX CS
        GP41 137 lanwfkllnslWvkyivvilvglrivlivlsllPvvf 173
                   +  +ll+ +W+k + + l+g++ ++ +  + P+ +
  EFC36457.1 210 NEDETNLLKRIWIK-MKATLIGILKIFKIKKIHPLAI 245
                 44556677777777.6677777777777777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       935  (0.0521501); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2159.82
//
Query:       EFC36458.1  [L=791]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.87    9.7   3.8        1.5    8.9   1.1    2.6  3  HemolysinCabind  RTX calcium-binding nonapeptide repeat (4 co


Domain annotation for each model (and alignments):
>> HemolysinCabind  RTX calcium-binding nonapeptide repeat (4 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   1.1   8.2e-05       1.5      11      25 ..     140     154 ..     139     158 .. 0.70
   2 ?   -1.3   0.0      0.13   2.3e+03      23      29 ..     275     281 ..     270     282 .. 0.61
   3 ?   -1.3   0.0      0.13   2.3e+03       9      18 ..     615     624 ..     612     625 .. 0.68

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 8.2e-05
  HemolysinCabind  11 GgaGnDtiyGgaGnD 25 
                      G +G+Dt+yG  G D
       EFC36458.1 140 GENGADTLYGYTGED 154
                      677777777777777 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.13
  HemolysinCabind  23 GnDtlyG 29 
                      GnD ++G
       EFC36458.1 275 GNDMIIG 281
                      5555554 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.13
  HemolysinCabind   9 lvGgaGnDti 18 
                      l+G+ Gn+++
       EFC36458.1 615 LQGNVGNNSL 624
                      6677777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (791 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1478  (0.0824363); expected 358.6 (0.02)
Passed bias filter:                      752  (0.0419432); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.79u 0.37s 00:00:01.16 Elapsed: 00:00:00.53
# Mc/sec: 4528.58
//
Query:       EFC36459.1  [L=1538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.1e-43  147.2  14.1      5e-40  137.6   6.1    2.7  2  REJ       REJ domain
    5.4e-19   68.3 240.2    8.4e-05   22.9  10.5   16.4 15  EGF_2     EGF-like domain
    6.4e-06   26.1   0.5    3.9e-05   23.6   0.5    2.4  1  TMEM154   TMEM154 protein family
     0.0023   17.4   0.5     0.0046   16.4   0.5    1.4  1  DAG1      Dystroglycan (Dystrophin-associated glycoprotein 1)
     0.0038   16.9   3.2     0.0047   16.6   0.1    2.8  3  Big_3_3   Bacterial Ig-like domain (group 3)
  ------ inclusion threshold ------
      0.012   15.9   5.1      0.012   15.9   5.1   13.8 13  EGF       EGF-like domain
      0.019   15.4   4.9      0.048   14.1   4.9    1.6  1  DUF4713   Domain of unknown function (DUF4713)
       0.13   12.2   0.8        0.3   10.9   0.8    1.6  1  TMIE      TMIE protein
       0.14   13.1   1.0       0.77   10.7   0.2    2.4  2  EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
       0.16   12.3   2.4          1    9.7   0.4    2.4  2  Orf78     Orf78 (ac78)
          1    9.7   4.6       0.43   10.9   0.8    2.2  2  DUF4064   Protein of unknown function (DUF4064)


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   1.1   1.7e-05     0.028      99     243 ..     647     776 ..     621     844 .. 0.71
   2 !  137.6   6.1   3.1e-43     5e-40     151     434 ..     879    1154 ..     837    1162 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.7e-05
         REJ  99 gnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrs.rksasteqtil 196
                 gn++Ld s S+  d+      ql ++++     +  ++n+d +lln+  + ++        s ++fp s+l a+ ty +++ v+ +   k + ++ t  
  EFC36459.1 647 GNMILDSSASSSLDRR-----QLIFSYSA----TLAPSNQDITLLNSLISGST-------DSFVKFPVSQLSAG-TYSVQVAVQSSFsGKVSYATYTFS 728
                 89*******9999877.....68899999....5677999**99999998888.......**************.8*****9999877889******** PP

         REJ 197 vvdgepplvsiecisncngkvnpndrlvllasclncakdlkdvt.feW 243
                 v+++ pp+++i+  +  + ++  +   v  +  ++c + + +++  ++
  EFC36459.1 729 VTESSPPTLTIRNGASSSITIGNSLAIVPVVTFPSCYRGNPSASsLKY 776
                 ***********9988888877777664444444445444333333444 PP

  == domain 2  score: 137.6 bits;  conditional E-value: 3.1e-43
         REJ  151 s..........gtllssstssltfpaselvanltynftltvskrsrksasteqtilvvdgepplvsiecisncng...kvnpndrlvllasclncak 234 
                  +           + l+  +s+l f  ++++++  y ft ++sk+sr s++++++i++ + +   v+i + +  +     ++p+++l+l+a++l++  
  EFC36459.1  879 DletlasctgfDNGLNIDQSTLLF-DKQFTPG-SYMFTAVFSKSSRSSSTSVKVIVTSQTKATSVRIYIDTPSGSdvsAIDPSNDLILQAQSLDLL- 972 
                  144555555554555666666666.6789999.7************999999999999999988888777776651114678888**********6. PP

         REJ  235 dlkdvtfeWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaf 331 
                   + + +f+W           +  ++t   t   ++ +L+i ++ L +g+sy +++  t+++g k+g asisf+vn+pP+ G ++v P++gval+++f
  EFC36459.1  973 -SPQRVFSW-----------SSSDFTFDSTIDLTKKYLTIPKSLLAPGASYSVSI--TVTDGVKTGQASISFIVNAPPSLGIFEVSPSTGVALVDEF 1055
                  .456679**...........2234677778888889*******************..9999999********************************* PP

         REJ  332 tvrC.qgwtDkdqPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarvsvsltitVkppavnnstieel..len 425 
                  +v+C +gw+D ++PL++++  + ++ ++ +++l e+s+  s ++ +P+G+       ++++ VyD kga+++++ +i+V+ p   +s i+ l  l +
  EFC36459.1 1056 KVSCgNGWSDSQLPLSFKF-VFRQKGEEIWKVLKEKSETRSFRTSMPTGQL------EIKAIVYDAKGAFTETTSNINVTTPVDVSSAIQSLsvLTT 1145
                  *******************.777777888*********************9......9**********************99999995555401555 PP

         REJ  426 rtrnenels 434 
                  +t++ ++ s
  EFC36459.1 1146 STLTPSSAS 1154
                  555555555 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1  11.9   2.7e-05     0.044       7      32 .]      12      37 ..       2      37 .. 0.86
   2 !    6.3  12.9    0.0077        12       4      27 ..      48      71 ..      42      77 .. 0.86
   3 !   22.9  10.5   5.1e-08   8.4e-05       5      32 .]     120     146 ..     116     146 .. 0.85
   4 !    9.4   9.0    0.0008       1.3       5      32 .]     159     186 ..     151     186 .. 0.88
   5 !   19.4   9.8   6.1e-07     0.001       7      32 .]     201     225 ..     196     225 .. 0.92
   6 ?    5.6   7.4     0.013        21      14      32 .]     241     258 ..     239     258 .. 0.84
   7 !   12.5   5.7     9e-05      0.15       7      32 .]     273     297 ..     268     297 .. 0.92
   8 ?    4.3  12.6     0.033        55       6      32 .]     310     336 ..     302     336 .. 0.80
   9 ?    2.3   1.5      0.14   2.3e+02      22      32 .]     338     348 ..     338     348 .. 0.95
  10 !   19.7   8.0   5.2e-07   0.00084       5      32 .]     361     391 ..     357     391 .. 0.90
  11 ?    2.6  12.1      0.11   1.8e+02       4      27 ..     403     425 ..     401     443 .. 0.86
  12 !   14.5  12.3   2.1e-05     0.035       1      32 []     448     477 ..     448     477 .. 0.91
  13 ?    0.4   0.6      0.54   8.8e+02      22      32 .]     479     489 ..     479     489 .. 0.95
  14 !   11.8  14.6   0.00015      0.24       1      32 []     493     522 ..     493     522 .. 0.94
  15 ?    5.8   1.9     0.011        18      23      32 .]     525     534 ..     524     534 .. 0.96

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.7e-05
       EGF_2  7 iCgg.hGtCvnqcGqCdCdsgyqGktC 32
                 C++ +G Cv ++ qC+C+++y+G +C
  EFC36459.1 12 VCSNgRGRCVGAN-QCECETNYFGSQC 37
                68877*****777.************* PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0077
       EGF_2  4 s.deiCgghGtCvnqcGqCdCdsgy 27
                + ++ C ghG+C++++ +C C++gy
  EFC36459.1 48 NdSSVCYGHGSCESFN-NCTCSDGY 71
                34889********999.8******9 PP

  == domain 3  score: 22.9 bits;  conditional E-value: 5.1e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hGtC + + +C+C+sgy+G+ C
  EFC36459.1 120 STVCSSHGTCLDNN-NCKCQSGYFGNEC 146
                 688*******6555.8************ PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.0008
       EGF_2   5 deiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g +G+C +++ +C+C  g+ G  C
  EFC36459.1 159 TNVCNGpNGQCSSPN-NCSCTIGFLGLEC 186
                 578*********999.8*********999 PP

  == domain 5  score: 19.4 bits;  conditional E-value: 6.1e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+G+C+ +  +C C++g++G +C
  EFC36459.1 201 VCNGNGSCNGLD-KCACNQGWSGSQC 225
                 6********777.9************ PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.013
       EGF_2  14 Cvnqc.GqCdCdsgyqGktC 32 
                 C   + G+C+C++gy+G +C
  EFC36459.1 241 CS--GrGVCKCSPGYTGGNC 258
                 66..448999*******999 PP

  == domain 7  score: 12.5 bits;  conditional E-value: 9e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C g+G+Cv +   C+Cds ++G  C
  EFC36459.1 273 VCYGNGKCVGPD-TCKCDSLFSGMEC 297
                 69*******888.9*********999 PP

  == domain 8  score: 4.3 bits;  conditional E-value: 0.033
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ +GtC++    C+C+ ++ G +C
  EFC36459.1 310 GGCSFRGTCNSYSHLCECKGNFAGSSC 336
                 55*******933336************ PP

  == domain 9  score: 2.3 bits;  conditional E-value: 0.14
       EGF_2  22 dCdsgyqGktC 32 
                 +C+sg++G +C
  EFC36459.1 338 SCKSGFTGTSC 348
                 5********** PP

  == domain 10  score: 19.7 bits;  conditional E-value: 5.2e-07
       EGF_2   5 deiCgghGtCvnqcG...qCdCdsgyqGktC 32 
                 ++ C+g+G+C + +G   +C+C+ +y+G++C
  EFC36459.1 361 KSVCNGRGSCSSVNGsspVCVCSGNYYGANC 391
                 578*******999**7777************ PP

  == domain 11  score: 2.6 bits;  conditional E-value: 0.11
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgy 27 
                 +++ C+ +G+C ++   C+C+ +y
  EFC36459.1 403 NSSVCSSRGSCLSPD-TCSCKGNY 425
                 4689*******9999.9***9887 PP

  == domain 12  score: 14.5 bits;  conditional E-value: 2.1e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C +  ++C+  GtC+++  qC+C+ +y G +C
  EFC36459.1 448 CDS-ATTCNSKGTCNDKL-QCVCSGNYAGTYC 477
                 555.589***********.************* PP

  == domain 13  score: 0.4 bits;  conditional E-value: 0.54
       EGF_2  22 dCdsgyqGktC 32 
                 +C++g+ G +C
  EFC36459.1 479 KCKDGFVGTSC 489
                 6*********9 PP

  == domain 14  score: 11.8 bits;  conditional E-value: 0.00015
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 Csa  ++C+g GtC  q G+C C+ +  Gk+C
  EFC36459.1 493 CSA-ATTCNGKGTCS-QIGECICSGNTNGKKC 522
                 998.599*******9.78************** PP

  == domain 15  score: 5.8 bits;  conditional E-value: 0.011
       EGF_2  23 CdsgyqGktC 32 
                 C++g++G++C
  EFC36459.1 525 CNAGWYGDKC 534
                 ********** PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   0.5   2.4e-08   3.9e-05      22      88 ..    1444    1515 ..    1419    1533 .. 0.63

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 2.4e-08
     TMEM154   22 adatsaasteseslk...qeeakeslssaelsnesdqlel..vlmiiiPlvllillllvviiliqkkkrkrs 88  
                  + ++s a++ +e ++   + ++  s+  + +  +s++le    l++++P +++++++++v++   +kk+++ 
  EFC36459.1 1444 SSSGSYAVVSEEVVApqaSPKTSSSKTTTVITTKSNNLEYlaFLVLLVPVIAVVVIIIIVVVCCLRKKKTKY 1515
                  33333444433333364444555666667788999999987789********99999988887755555443 PP

>> DAG1  Dystroglycan (Dystrophin-associated glycoprotein 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.5   2.8e-06    0.0046     121     177 ..    1457    1514 ..    1429    1530 .. 0.67

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.8e-06
                  XXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        DAG1  121 eiPsevasteapee..daeksseddvylhtvipavvvaailliagiiamicyrkkrkGk 177 
                    P++++ t++ ++      +s++ +yl  ++  v v+a+++i  i++++c+rkk+  k
  EFC36459.1 1457 VAPQASPKTSSSKTttVITTKSNNLEYLAFLVLLVPVIAVVVIIIIVVVCCLRKKKT-K 1514
                  33444444333333003456788999*****************99*******98764.3 PP

>> Big_3_3  Bacterial Ig-like domain (group 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.1   2.9e-06    0.0047       4      56 ..     693     745 ..     690     756 .. 0.88
   2 ?   -2.9   0.0       2.9   4.7e+03     123     135 ..    1010    1022 ..    1005    1055 .. 0.46
   3 ?   -2.5   0.4       2.2   3.5e+03      57     108 ..    1344    1394 ..    1320    1399 .. 0.56

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 2.9e-06
     Big_3_3   4 tvtfdlkelpeGkynlvlaakdtfnnqvtksllstilvdntpPtvsisegkki 56 
                  v+f +++l+ G+y++++a +  f ++v   + +  +++ +pPt++i +g++ 
  EFC36459.1 693 FVKFPVSQLSAGTYSVQVAVQSSFSGKVSYATYTFSVTESSPPTLTIRNGASS 745
                 689**************************9999888899********777654 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.9
     Big_3_3  123 sYtltvkaeDeag 135 
                  sY+++++++D   
  EFC36459.1 1010 SYSVSITVTDGVK 1022
                  4444444444332 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.2
     Big_3_3   57 sdgavvkglenlritladaldkskltsialsGGpasDkVelswveegkdvys 108 
                  +  + v +l+n++  +  ++++  +++++      s  V+++ +++++ +y 
  EFC36459.1 1344 NSLSQVSSLDNVKLVMKVQTQAKAVSKLVTFRVE-SNDVDVGVSSNSNTTYI 1394
                  3445566666666555554444445444433333.33466666666666665 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   6.1      0.53   8.7e+02       6      31 ..      13      35 ..       2      36 .. 0.72
   2 ?    0.2   6.0      0.59   9.6e+02       5      29 ..      49      72 ..      46      75 .. 0.77
   3 ?   15.9   5.1   7.4e-06     0.012       5      31 ..     121     144 ..     115     145 .. 0.86
   4 ?   -0.8   1.0       1.2     2e+03      21      28 ..     174     181 ..     165     184 .. 0.70
   5 ?   10.7   2.2   0.00032      0.52       6      31 ..     202     223 ..     195     224 .. 0.88
   6 ?    4.4   4.5     0.029        48      17      30 ..     242     255 ..     225     257 .. 0.81
   7 ?    3.9   4.8     0.041        67       6      30 ..     274     294 ..     263     294 .. 0.80
   8 ?   -0.8   7.2       1.2   1.9e+03       4      30 ..     310     333 ..     302     335 .. 0.78
   9 ?   -1.0   0.1       1.5   2.4e+03      24      30 ..     339     345 ..     338     347 .. 0.90
  10 ?    6.0   2.4    0.0092        15       5      31 ..     361     389 ..     357     390 .. 0.78
  11 ?    2.0   4.3      0.17   2.7e+02       6      26 ..     407     423 ..     396     428 .. 0.82
  12 ?    3.5   7.3     0.056        92       1      30 [.     448     474 ..     448     476 .. 0.85
  13 ?   -0.8   8.1       1.2     2e+03       1      25 [.     493     514 ..     493     521 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.53
                STTT.-EEEEETTTEEEEEECTTEEST CS
         EGF  6 Csng.GtCvdtgrggytCiCpeGytGk 31
                Csng G+C     g  +C+C + y+G+
  EFC36459.1 13 CSNGrGRC---V-GANQCECETNYFGS 35
                66653679...4.5668********96 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.59
                T...STTT-EEEEETTTEEEEEECTTEE CS
         EGF  5 p...CsngGtCvdtgrggytCiCpeGyt 29
                    C ++G C        +C+C+ Gy 
  EFC36459.1 49 DssvCYGHGSC----ESFNNCTCSDGYG 72
                4445*******....45569******95 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 7.4e-06
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + Cs +GtC+d+     +C+C++Gy+G+
  EFC36459.1 121 TvCSSHGTCLDNN----NCKCQSGYFGN 144
                 36*******9999....*********97 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 1.2
                 EEEECTTE CS
         EGF  21 tCiCpeGy 28 
                 +C C++G+
  EFC36459.1 174 NCSCTIGF 181
                 69999988 PP

  == domain 5  score: 10.7 bits;  conditional E-value: 0.00032
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+++G C    +g  +C C +G++G+
  EFC36459.1 202 CNGNGSC----NGLDKCACNQGWSGS 223
                 *******....999**********97 PP

  == domain 6  score: 4.4 bits;  conditional E-value: 0.029
                 TTEEEEEECTTEES CS
         EGF  17 rggytCiCpeGytG 30 
                 +g+  C+C++GytG
  EFC36459.1 242 SGRGVCKCSPGYTG 255
                 57788********9 PP

  == domain 7  score: 3.9 bits;  conditional E-value: 0.041
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 C ++G+Cv       tC+C++ ++G
  EFC36459.1 274 CYGNGKCVG----PDTCKCDSLFSG 294
                 *******55....55*****99987 PP

  == domain 8  score: -0.8 bits;  conditional E-value: 1.2
                 TTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytG 30 
                 + Cs +GtC +    ++ C+C+  ++G
  EFC36459.1 310 GGCSFRGTCNS---YSHLCECKGNFAG 333
                 34999****44...46*****988888 PP

  == domain 9  score: -1.0 bits;  conditional E-value: 1.5
                 ECTTEES CS
         EGF  24 CpeGytG 30 
                 C++G+tG
  EFC36459.1 339 CKSGFTG 345
                 ******9 PP

  == domain 10  score: 6.0 bits;  conditional E-value: 0.0092
                 T..STTT-EE..EEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtC..vdtgrggytCiCpeGytGk 31 
                 +  C+++G C  v+  + ++ C C+  y G+
  EFC36459.1 361 KsvCNGRGSCssVN--GSSPVCVCSGNYYGA 389
                 445*******5444..56******9999987 PP

  == domain 11  score: 2.0 bits;  conditional E-value: 0.17
                 STTT-EEEEETTTEEEEEECT CS
         EGF   6 CsngGtCvdtgrggytCiCpe 26 
                 Cs +G C+++     tC C+ 
  EFC36459.1 407 CSSRGSCLSPD----TCSCKG 423
                 *******9999....****85 PP

  == domain 12  score: 3.5 bits;  conditional E-value: 0.056
                 GCSTT.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytG 30 
                 C++ + C+  GtC d      +C C+  y+G
  EFC36459.1 448 CDSATtCNSKGTCNDKL----QCVCSGNYAG 474
                 999555*******8888....****999988 PP

  == domain 13  score: -0.8 bits;  conditional E-value: 1.2
                 GCSTT.STTT-EEEEETTTEEEEEEC CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCp 25 
                 Cs  + C++ GtC + g    +CiC+
  EFC36459.1 493 CSAATtCNGKGTCSQIG----ECICS 514
                 888455*******9999....****6 PP

>> DUF4713  Domain of unknown function (DUF4713)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   4.9     3e-05     0.048      20      51 ..    1477    1508 ..    1474    1510 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 3e-05
     DUF4713   20 fqspwdiaaFvvlllFigtVllLlllaclycc 51  
                  + ++++ +aF vll+ +++V++++++++++c 
  EFC36459.1 1477 KSNNLEYLAFLVLLVPVIAVVVIIIIVVVCCL 1508
                  56799*************************95 PP

>> TMIE  TMIE protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.8   0.00019       0.3      14      51 ..    1490    1527 ..    1485    1535 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00019
        TMIE   14 viaivllvvlaivillCCvirfRiPRTkqeIeadyark 51  
                  ++ ++++vv++i++++CC+ + +   Tk + e ++  k
  EFC36459.1 1490 LVPVIAVVVIIIIVVVCCLRKKKTKYTKGQHERNFEDK 1527
                  56678999999*******99999999998888877665 PP

>> EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0       1.4   2.2e+03      42      58 ..     931     946 ..     910     949 .. 0.52
   2 ?   10.7   0.2   0.00047      0.77       7      36 ..    1491    1520 ..    1486    1536 .. 0.56

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 1.4
    EphA2_TM  42 kkeeensgkkglktYvD 58 
                  ++++++ + ++++Y+D
  EFC36459.1 931 IVTSQTKAT-SVRIYID 946
                 233333333.7*****9 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00047
    EphA2_TM    7 aglvllvilvilvlvlvrrrsknrkqksdl 36  
                  + ++ +v+++i+v+v++ r++k +  k ++
  EFC36459.1 1491 VPVIAVVVIIIIVVVCCLRKKKTKYTKGQH 1520
                  445555555566666666666655555442 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1      0.24   3.9e+02      16      45 ..    1240    1269 ..    1233    1294 .. 0.64
   2 ?    9.7   0.4   0.00063         1      49      97 ..    1470    1517 ..    1449    1525 .. 0.60

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.24
       Orf78   16 yIPLKLAlndldnddndkaenkkekksaae 45  
                  y+ LKLA +d+++  +++a+ +++ +++ +
  EFC36459.1 1240 YLLLKLASQDINSALDSAASIQTHVSKKVT 1269
                  7779******96665555544444333333 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00063
       Orf78   49 itekesn....aaekaqalnillisllavvcvlvllyviyYfvilrerqkssv 97  
                  +     +    +++++ ++ ++l+ l+ v++v+v++++++   + ++++k+++
  EFC36459.1 1470 T-----TtvitTKSNNLEYLAFLVLLVPVIAVVVIIIIVVVCCLRKKKTKYTK 1517
                  1.....12232456667788888888888888888877766555555555544 PP

>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.2       1.6   2.6e+03      47      83 ..    1130    1166 ..    1109    1212 .. 0.64
   2 ?   10.9   0.8   0.00026      0.43      14      87 ..    1428    1514 ..    1422    1518 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.6
     DUF4064   47 gedasavleflstllivlgvialiaivlgivgalllk 83  
                    d+s++  +ls+l++ +++ +  +++l+++ a++  
  EFC36459.1 1130 PVDVSSAIQSLSVLTTSTLTPSSASSALSVILAVKPT 1166
                  3344444455555555556667777777777777665 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00026
     DUF4064   14 ilgillglllllflfllssgefsqeltee.............qalsgedasavleflstllivlgvialiaivlgivgalllkknkk 87  
                   + i ++ ++++++ ++ssg+++   +e              + +  +  s+ le+l  l+++  via++ i++++v + l kk++k
  EFC36459.1 1428 GCTISSTSGGMFTIQVSSSGSYAVVSEEVvapqaspktssskTTTVITTKSNNLEYLAFLVLLVPVIAVVVIIIIVVVCCLRKKKTK 1514
                  478999999999999999999998887779999998888776666666777777999999999999999999999999999898887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1347  (0.0751297); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 1.09u 0.35s 00:00:01.44 Elapsed: 00:00:00.54
# Mc/sec: 8637.60
//
Query:       EFC36460.1  [L=279]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.042   13.7   0.6       0.14   12.0   0.6    1.9  1  PDR_CDR   CDR ABC transporter


Domain annotation for each model (and alignments):
>> PDR_CDR  CDR ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.6   8.1e-06      0.14      50      89 ..       4      43 ..       2      46 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 8.1e-06
     PDR_CDR 50 fgiliaflifflalyllatelisaekskgevlvfkrgkap 89
                + +++a++ ff+++++++t+ +++++++g v++ k+++++
  EFC36460.1  4 LAVICAYFTFFVLANFITTSALEQATKRGFVKILKQKEQK 43
                5799***************************999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1843.27
//
Query:       EFC36461.1  [L=109]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.39u 0.27s 00:00:00.66 Elapsed: 00:00:00.42
# Mc/sec: 784.99
//
Query:       EFC36462.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.014   15.9   0.3      0.025   15.1   0.3    1.4  1  Peptidase_S66C  LD-carboxypeptidase C-terminal domain
      0.089   12.2   3.6      0.097   12.1   1.5    1.7  2  Ins_P5_2-kin    Inositol-pentakisphosphate 2-kinase
       0.48   10.6   2.8        3.7    7.8   2.8    2.3  1  CRS1_YhbY       CRS1 / YhbY (CRM) domain


Domain annotation for each model (and alignments):
>> Peptidase_S66C  LD-carboxypeptidase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.3   4.1e-06     0.025      22      92 ..     109     185 ..      93     193 .. 0.63

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 4.1e-06
                     ---TT..EEEEEE-........-TTHHHHHHHHHHHHCTST.....TGGG--EEEEEE--..G...CC...---HHHHHHHHHT CS
  Peptidase_S66C  22 pekdlkgkILflEd........vsespyridrmLtqlkeag.....vldkvkGivlGrftkpeekeeeeekeeykealeevlae 92 
                     p   +k+++L+ E         ++e++ +id+ ++qlk++      ++++++++++G  +k+     +e +  +++ lee+ ++
      EFC36462.1 109 P--LMKDQLLVWELekaellkiTNEKIAEIDKEMEQLKNSSfaniqIIKGLAAFLVGYSEKTG----KEFRSAKEKELEEI-DD 185
                     4..3455555544322444432355**************99888889**********655442....22333344445554.33 PP

>> Ins_P5_2-kin  Inositol-pentakisphosphate 2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.5   1.6e-05     0.097      26      87 ..      17      78 ..       7      95 .. 0.87
   2 ?   -0.3   0.0     0.093   5.5e+02      51      88 ..     107     144 ..      86     178 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.6e-05
                  EEEEEESTSHHHHT-SSHHHHHHHHHH..HTTHHHHTSTSB---EEEEE-HHHHHHHHHHHGGG CS
  Ins_P5_2-kin 26 RlrKapksekdseskaeseeeslsfvr..kvispllgseylvdqelvrldrefleelnekleae 87
                  Rl+K+pk  ++ +++++++ +s +f++   v  p  ++  + + + v+++++f+ e+++++++ 
    EFC36462.1 17 RLKKEPK--QELQASKDKDIQSEQFQDnnTVRVPTVEKAQVKKSKPVDVSKNFVTEIKKSIKKA 78
                  9******..888888888888888888557899***************************9876 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.093
                   HHHTTHHHHTSTSB---EEEEE-HHHHHHHHHHHGGGS CS
  Ins_P5_2-kin  51 vrkvispllgseylvdqelvrldrefleelnekleaer 88 
                   ++ +++  l    l ++el ++++e ++e+++++e+ +
    EFC36462.1 107 YEPLMKDQLLVWELEKAELLKITNEKIAEIDKEMEQLK 144
                   33344444444555567888899999999988887764 PP

>> CRS1_YhbY  CRS1 / YhbY (CRM) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   2.8   0.00062       3.7      26      68 ..      62     104 ..      37     169 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00062
   CRS1_YhbY  26 GvtkevvdeiheklkteelvkvkcegppalnmkrmaeiLeekt 68 
                 +v+k++v ei++ +k+  l    ++ p+ ln +++++ Le+++
  EFC36462.1  62 DVSKNFVTEIKKSIKKAMLTDADLKSPDMLNCNEVIRSLEKEL 104
                 699*************************************964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1913  (0.106699); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 1138.00
//
Query:       EFC36463.1  [L=686]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0063   15.3   0.3      0.012   14.4   0.3    1.4  1  GSH_synth_ATP  Eukaryotic glutathione synthase, ATP binding d
  ------ inclusion threshold ------
       0.12   12.8   0.4       0.68   10.4   0.4    2.3  1  DUF2533        Protein of unknown function (DUF2533)


Domain annotation for each model (and alignments):
>> GSH_synth_ATP  Eukaryotic glutathione synthase, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.3   1.3e-06     0.012      53     117 ..     555     622 ..     527     675 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.3e-06
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxx RF
  GSH_synth_ATP  53 lfeeAvevqkayneLyakvasdeefLeevlee..vikvDeFtakLweiyekvkke.glvqklslglfR 117
                      e+ +++q++y+ L ++  +d+e+L e+ ++   +++D+F + + +i+e+v +e g ++ l   l R
     EFC36463.1 555 ILEDSQRIQTVYQLLRKNTIRDDEWLYELEQKkaNAEFDQFNSDFSKIFESVDNEfGNENGLDSVLSR 622
                    568899*********************99888667889**************9996666666666655 PP

>> DUF2533  Protein of unknown function (DUF2533)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.4   7.6e-05      0.68      41      80 ..      73     115 ..      65     117 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 7.6e-05
     DUF2533  41 kgkpfsvekiNevTkeiNe.lak..kgivptRklVtkemvkey 80 
                  +++ ++e++N v +++Ne +a+  +g++   k+V+  mv++y
  EFC36463.1  73 MNEQAAMEQVNIVIDNMNEkIATfvNGQLIPAKYVADSMVNDY 115
                 6788899***********83454335889999**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (686 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1004  (0.0559987); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 4146.26
//
Query:       EFC36464.1  [L=1700]
Description: polyubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.4e-17   62.4   0.2    7.6e-17   60.8   0.2    1.8  1  ubiquitin    Ubiquitin family
    3.5e-11   43.7   5.9    5.8e-11   42.9   0.2    3.3  3  PHM7_cyt     Cytosolic domain of 10TM putative phosphate tran
    1.7e-05   24.5   0.2    4.8e-05   23.1   0.2    1.7  1  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
  ------ inclusion threshold ------
      0.022   14.6   0.2       0.47   10.3   0.0    2.5  2  RRM_1        RNA recognition motif. (a.k.a. RRM, RBD, or RNP 
      0.042   14.5   2.0        3.9    8.2   0.1    3.9  3  DUF573       Protein of unknown function, DUF573
       0.39   11.3   0.0       0.39   11.3   0.0    3.6  4  DUF2407      DUF2407 ubiquitin-like domain
       0.46   10.6   0.0       0.46   10.6   0.0    2.1  2  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.8   0.2     3e-20   7.6e-17       3      68 ..     930     995 ..     929     998 .. 0.98

  Alignments for each domain:
  == domain 1  score: 60.8 bits;  conditional E-value: 3e-20
                 EEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEE CS
   ubiquitin   3 vktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlv 68 
                 vk ++g++i+l+v+++  vee+ + +aek + +++ qrLiy+GkvL++  +l++y+i +++++hlv
  EFC36464.1 930 VKAMNGQQIELQVDPEIDVEEFRKLLAEKSNTAPHLQRLIYQGKVLKNGTKLSDYKISNDHVIHLV 995
                 999**************************************************************8 PP

>> PHM7_cyt  Cytosolic domain of 10TM putative phosphate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.9   0.2   2.3e-14   5.8e-11       2     176 .]     404     597 ..     403     597 .. 0.71
   2 ?   -1.8   0.1       1.2   3.2e+03      41      62 ..     892     913 ..     866     985 .. 0.64
   3 ?    2.3   0.1     0.066   1.7e+02      33      72 ..    1133    1173 ..    1108    1312 .. 0.62

  Alignments for each domain:
  == domain 1  score: 42.9 bits;  conditional E-value: 2.3e-14
    PHM7_cyt   2 rTvlvtgiPkelrseeklkeffee.lypgkvves........vqivrdvkkldklveerekavrkleaalskykkngkklpkkrpt.hklgflglklig 90 
                 +T++v++iPke + +e+l e+f+e +  gk+ ++        ++++ ++++l +l +   k+++kle ++      ++    k pt   l ++  +   
  EFC36464.1 404 YTLMVKNIPKEITAKEELGELFNEeILLGKYRTDdewkehyvCHVAVNLNHLTELEKALAKVEKKLENIK------PD----KPPTtGCLAKCTSR-ED 491
                 8*********************753666666333444445556777777777777777777777777763......33....33440333333322.12 PP

    PHM7_cyt  91 kkvdaidyyrekleeldeeieeerekvkkkp................lgaaFvtfesersaaavak..qakcaaqiqqssnptl...kpkkwtvelAPe 168
                 + +   d ++ek++ ++++++  ++ ++  +                +g++Fvtf s  +a++v+   +a++ +++ q +   +   + k+++v+ A  
  EFC36464.1 492 QLILERDQITEKINTIKKKYYVNESMENDAFlttgafntndptdvygTGYGFVTFFSMDEAKEVLRnfNASR-SKVTQWMEYLIpfyEDKEIVVTAAVP 589
                 33555688999999999999888887644446677778888899999*****************99864444.3444445555556699********** PP

    PHM7_cyt 169 PrDviWeN 176
                 P+Dvi eN
  EFC36464.1 590 PDDVIFEN 597
                 ******99 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.2
    PHM7_cyt  41 vkkldklveerekavrkleaal 62 
                 +++ +kl ++ ++a+r+   + 
  EFC36464.1 892 IDEARKLKKKMKNAMRAALFVA 913
                 4444555555555555544443 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.066
    PHM7_cyt   33 esvqivrdvkkldklveerekavrkleaalsky.kkngkkl 72  
                  + ++ +r + +l +  ++r+++vr+le++ + + ++++++l
  EFC36464.1 1133 SLINGARSIINLLNNEQQRQNIVRSLETVVNSLsESTPNRL 1173
                  447788899999999999*********99866525555544 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.2   1.9e-08   4.8e-05       5      71 ..     930     995 ..     929     995 .. 0.97

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.9e-08
                 EEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEE CS
   Rad60-SLD   5 lkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvv 71 
                 +k+++g++++++V+p+  v++  + +++k ++ +   +rLi++G+ L++   + d++i ++ +i++v
  EFC36464.1 930 VKAMNGQQIELQVDPEIDVEEFRKLLAEKSNTAP-HLQRLIYQGKVLKNGTKLSDYKISNDHVIHLV 995
                 899*******************************.99***************************986 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.12   3.2e+02       1      20 [.     406     426 ..     406     428 .. 0.84
   2 ?   10.3   0.0   0.00018      0.47      39      61 ..     539     561 ..     530     568 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.12
                 EEEESETTTSS.HHHHHHHHH CS
       RRM_1   1 lfVgnLppdvt.eeeLkelFs 20 
                 l+V+n+p+++t +eeL elF+
  EFC36464.1 406 LMVKNIPKEITaKEELGELFN 426
                 78****999985788999997 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00018
                 EEEEEEEESSHHHHHHHHHHHTT CS
       RRM_1  39 kgfafVeFeskedAekAlealng 61 
                 +g++fV+F s ++A++ l+++n 
  EFC36464.1 539 TGYGFVTFFSMDEAKEVLRNFNA 561
                 79*****************9996 PP

>> DUF573  Protein of unknown function, DUF573
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.1    0.0015       3.9      46      71 ..     494     519 ..     456     537 .. 0.66
   2 ?    2.2   0.2      0.12     3e+02      42      89 ..     881     929 ..     842     933 .. 0.75
   3 ?   -0.4   0.0      0.72   1.8e+03      40      89 ..    1386    1435 ..    1370    1439 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0015
      DUF573  46 dvsksqlseKlrrLkkkyrnavskik 71 
                   + +q++eK+ ++kkky  + s ++
  EFC36464.1 494 ILERDQITEKINTIKKKYYVNESMEN 519
                 34569*************98877644 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.12
      DUF573  42 slssdvsksqlseKlrrLkkkyrnavskik.kgkdpsfkkphdrklfel 89 
                 +l + +++  +++  r+Lkkk +na++ +    + ++ +++h+  +  l
  EFC36464.1 881 QLLDLYRHPYFIDEARKLKKKMKNAMRAALfVANSKQDTSTHNDVTLSL 929
                 444455567889999*********9987657555566666666666655 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.72
      DUF573   40 ksslssdvsksqlseKlrrLkkkyrnavskikkgkdpsfkkphdrklfel 89  
                  ++ l+ d s ++++eK+ ++ + +++ ++k ++ + +  +++ ++++ +l
  EFC36464.1 1386 SEVLKGDTSSENIQEKVEEIMTDFETYMDKNHDLQLEIASRAGESDVIDL 1435
                  44556688899**************9999976655555566666665555 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00015      0.39      27      72 ..     949    1004 ..     926    1041 .. 0.70
   2 ?   -1.8   0.4       1.8   4.7e+03      71      95 ..    1109    1133 ..    1079    1138 .. 0.59
   3 ?   -4.9   0.9         7   1.8e+04      61      90 ..    1276    1302 ..    1271    1311 .. 0.46
   4 ?   -1.1   0.0       1.1   2.9e+03      11      37 ..    1416    1444 ..    1412    1450 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00015
     DUF2407   27 agLkqliRerlpaelasrrLrLIyaGrlLedttslasslklpees............v 72  
                  ++ ++l  e+   ++a +  rLIy+G++L++ t+l++    + ++            +
  EFC36464.1  949 EEFRKLLAEKS--NTAPHLQRLIYQGKVLKNGTKLSDYKISNDHVihlvnmpppeaqA 1004
                  55555555554..7788888***************98776665555666665554440 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.8
     DUF2407   71 svsdkaekskekgkapvreqeeeri 95  
                   ++++++++++ ++++++++++ r 
  EFC36464.1 1109 AQRQQQQQQQQANNNTNNNNNQTRS 1133
                  2333334444444444444555555 PP

  == domain 3  score: -4.9 bits;  conditional E-value: 7
     DUF2407   61 lasslklpeesvsdkaekskekgkapvreq 90  
                  +++  ++p+   +++ ++++++  a++ +q
  EFC36464.1 1276 VNRTAQQPS---QQTPSQPSQTSSATTTQQ 1302
                  444444443...333344444444444322 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 1.1
     DUF2407   11 ipDleLdip..dpntttvagLkqliRerl 37  
                   +Dl+L+i     ++  +  L ql+R+ +
  EFC36464.1 1416 NHDLQLEIAsrAGESDVIDLLTQLVRNYV 1444
                  68******944445577889999999987 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00018      0.46      49     102 ..     964    1011 ..     954    1021 .. 0.70
   2 ?   -5.9   1.6         7   1.8e+04      91     103 ..    1108    1120 ..    1102    1127 .. 0.41

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00018
                   CCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE---SS----.XXXXX CS
  Rad60-SLD_2   49 ndlklilaGkiLennktlkelrlplgevkggvtvmHvvvrenlsekksekkakk 102 
                   +  +li++Gk+L+n   l+++++          v+H+v  ++ + + s+  +++
   EFC36464.1  964 HLQRLIYQGKVLKNGTKLSDYKISND------HVIHLVNMPPPEAQASSGSSSS 1011
                   4459*****************65443......4699998777666666555443 PP

  == domain 2  score: -5.9 bits;  conditional E-value: 7
                   SS----.XXXXXX CS
  Rad60-SLD_2   91 lsekksekkakka 103 
                   ++++++++++++a
   EFC36464.1 1108 TAQRQQQQQQQQA 1120
                   3333333333322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1700 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2409  (0.134363); expected 358.6 (0.02)
Passed bias filter:                      708  (0.0394891); expected 358.6 (0.02)
Passed Vit filter:                        84  (0.00468515); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.04u 0.30s 00:00:01.34 Elapsed: 00:00:00.51
# Mc/sec: 9956.19
//
Query:       EFC36465.1  [L=234]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (234 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       695  (0.038764); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1468.63
//
Query:       EFC36466.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       590  (0.0329076); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2289.31
//
Query:       EFC36467.1  [L=1877]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.4e-05   23.3   0.5        4.5    7.6   0.0    3.5  3  AAA_19    AAA domain
  ------ inclusion threshold ------
       0.23   11.5   2.7         15    5.7   0.4    3.2  3  HTH_Mga   M protein trans-acting positive regulator (MGA) HTH


Domain annotation for each model (and alignments):
>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0    0.0005       4.5      10      69 ..      85     159 ..      79     287 .. 0.79
   2 !    4.6   0.0    0.0043        38      60     129 ..     887     956 ..     858     962 .. 0.61
   3 !    7.1   0.0   0.00074       6.6       9      31 ..    1138    1160 ..    1131    1168 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0005
      AAA_19  10 ekvllvtaGpG.tGKTrvlkhivallvelggvkpeeillvaftgrAakelrerlaalgae..............a 69 
                 +kv+    G+G  GKT +++   ++++++ +    +   ++ +  +a++l+     l+++              +
  EFC36467.1  85 NKVFNFNPGAGqAGKTFTIQRNSTYYNQQSSKTITQTDYITINVESAEKLTSTNLLLQQDnfttsngmgggwisT 159
                 5556666688845*************************************9766455554655555555555441 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0043
      AAA_19  60 erlaalgaeatTiHrlalldfddlltealelle....eaeeekklqeeellivDEfqdvdelqyrLlkallgek 129
                 ++ ++ ++++ T H+l + ++   +    ++l+    +  + + l     +++DE + vd + ++++++ l++k
  EFC36467.1 887 DNYSVEEVKTWTSHQL-FTKLSANTGLSETILQpfleHDFNGNSL---VSVLIDEKSTVDTVTMAMINRFLESK 956
                 3444445557888888.4333333333334444433222222222...499*********99999999887554 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.00074
      AAA_19    9 kekvllvtaGpGtGKTrvlkhiv 31  
                  + +++ ++a+ GtGKT ++  ++
  EFC36467.1 1138 RGDTVSLIAPSGTGKTALISRRL 1160
                  678899*************9886 PP

>> HTH_Mga  M protein trans-acting positive regulator (MGA) HTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.4    0.0017        15      13      40 ..     117     144 ..     116     144 .. 0.92
   2 ?   -2.5   0.0      0.61   5.5e+03      25      40 ..     905     920 ..     903     923 .. 0.82
   3 ?    4.0   0.0    0.0055        49      10      44 ..    1257    1289 ..    1255    1292 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0017
     HTH_Mga  13 lLteneksltld.elakeLglseltlqsd 40 
                 ++t+ ++++t+  e a++L+ ++l lq+d
  EFC36467.1 117 TITQ-TDYITINvESAEKLTSTNLLLQQD 144
                 5788.9*****99**************97 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.61
     HTH_Mga  25 elakeLglseltlqsd 40 
                 +l+ ++glse +lq  
  EFC36467.1 905 KLSANTGLSETILQPF 920
                 68999*******9965 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.0055
     HTH_Mga   10 LlelLteneksltldelakeLglseltlqsdiseL 44  
                  + ++L++ +++ ++d + +  +++++ +++ i++L
  EFC36467.1 1257 IFNYLIK-NRWVEYD-IEELRNCTSSLVNNLIQKL 1289
                  6799***.******7.99999***********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1877 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.27s 00:00:01.04 Elapsed: 00:00:00.47
# Mc/sec: 11931.71
//
Query:       EFC36468.1  [L=287]
Description: C2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-25   88.8   0.0    3.5e-25   88.3   0.0    1.3  1  C2        C2 domain
    0.00091   19.5  32.7     0.0014   19.0  32.7    1.3  1  Pro-rich  Proline-rich


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.3   0.0   3.9e-29   3.5e-25       2      97 ..       3      97 ..       2     103 .. 0.94

  Alignments for each domain:
  == domain 1  score: 88.3 bits;  conditional E-value: 3.9e-29
                EEEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHHH CS
          C2  2 klevtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvWnekftfevaeleeakLeveVfdndrlskddfiGkveiplstllsgeea 97
                +l+vtv+ ++ L +kd++g+sdpyv+v + g++ +kT+v++ +lnP+W ++ftf+v++++++++++ Vfd+d ++k+d +G ++ pls+l++g ++
  EFC36468.1  3 TLTVTVVAGQRLVAKDISGTSDPYVVVRV-GSSSQKTSVKPATLNPTWAQTFTFSVSDPSREMVTFDVFDHDLIGKHDSMGSCSAPLSSLKRGVVE 97
                69***************************.***********************************************************8877655 PP

>> Pro-rich  Proline-rich
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0  32.7   1.5e-07    0.0014      72     152 ..     127     219 ..      87     251 .. 0.60

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 1.5e-07
    Pro-rich  72 ppqggpqqrPpqggkk..kpqgPPpqggpqrppPGk.pqgPPpqggnqqrrppqPg.gkpqgpppqgppkqggp.k........Ppqggnpqqp 152
                 p+qg pq +P q g      qg P+qg pq+p  G  +qg P+qg +qq  p+qP  g pq+p  q++ +q+g  +        P q g pqqp
  EFC36468.1 127 PQQGYPQ-QPMQTGYPqqPMQGYPQQGYPQQPMQGYpQQGYPQQGYPQQGYPQQPMqGYPQQPMVQQGYPQQGYpQqpmqgyapPMQTGYPQQP 219
                 6666666.34444432224456666666666664441345555555665566666533344443333322222211222222224444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (287 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       478  (0.0266607); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 1644.23
//
Query:       EFC36469.1  [L=459]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.19   11.2   0.4        0.3   10.5   0.4    1.3  1  DDE_Tnp_IS66  Transposase IS66 family
        9.1    6.9  14.0        0.9   10.1   6.2    2.6  3  Ino80_Iec3    IEC3 subunit of the Ino80 complex, chromatin re


Domain annotation for each model (and alignments):
>> DDE_Tnp_IS66  Transposase IS66 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.4   3.4e-05       0.3     246     279 ..     282     315 ..     258     318 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 3.4e-05
  DDE_Tnp_IS66 246 edgrvpidNNaaERaiRpvvlgRKnslfagseeG 279
                   ++++ +++N ++ER+++  +l+R+ns+ +++  +
    EFC36469.1 282 QQQQQQFSNAMIERSLKLSTLQRRNSFIVNNRSA 315
                   567789********************99987665 PP

>> Ino80_Iec3  IEC3 subunit of the Ino80 complex, chromatin re-modelling
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.7     0.073   6.5e+02      45     148 ..      29     130 ..      22     208 .. 0.62
   2 ?   10.1   6.2    0.0001       0.9      53     146 ..     234     334 ..     231     405 .. 0.81
   3 ?   -1.1   0.1      0.28   2.5e+03      81     126 ..     350     395 ..     329     441 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.073
  Ino80_Iec3  45 LLdlLldlNnsaqipsslRydLslpsvpsllspeeaaipsleadakgae..aklkeakeelaageitaedlreleeslkkskafapkkslasLlskvph 141
                 L++lLl  Nn  +i++++ y+  +++ ++ +  ++ + p+++  ++  +  +     +++ ++  +      e+  +l +s ++   +sl+sL +++++
  EFC36469.1  29 LMNLLLS-NNVSNISNNQLYNKLINNHNPDVNGQSFNCPPKTSGPSSPTnlT----FEQQIESHMMLD----ETFTQLPSSLHIPSDSSLSSLRRTTSY 118
                 6666665.66667777777776666666666666666666555544444222....233333333333....223356666677777888888877777 PP

  Ino80_Iec3 142 tslea.....pe 148
                 ++  +     ++
  EFC36469.1 119 PNKFHsfqqsSN 130
                 544333332222 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.0001
  Ino80_Iec3  53 NnsaqipsslRydLslps........vpsllspeeaaipsleadakgaeaklkeakeelaageitaedlreleeslkkskafapkkslasLlskvphts 143
                 Nn+ q+p++l ++Ls ++        ++s+++p+ +++++ ++++  ++++ ++  +++ + +++ ++l++++  + +++++  ++ l+ ++ k p ts
  EFC36469.1 234 NNTKQLPRQLSFNLSTTPfttfnnntTTSTCPPQFNNSQNNQNNHIIQQQQQQQFSNAMIERSLKLSTLQRRNSFIVNNRSASSNNLLSAVV-KNPSTS 331
                 9*****************9**99999889999999999999999999999999999999999999999999999999999999999888888.555443 PP

  Ino80_Iec3 144 lea 146
                  ++
  EFC36469.1 332 PAS 334
                 333 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.28
  Ino80_Iec3  81 aipsleadakgaeaklkeakeelaageitaedlreleeslkkskaf 126
                 a+ s + +++   ++l+ + +++++g++ +e+++++  ++++  +f
  EFC36469.1 350 ASLSRKSNSSSSLNNLRGISKQRKTGTLVTETVTTTSSTIHHCVEF 395
                 3333333333334888888888888888888877777777765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1465  (0.0817112); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2916.06
//
Query:       EFC36470.1  [L=511]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (511 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2470  (0.137766); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.79u 0.35s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 2785.45
//
Query:       EFC36471.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00028   20.3   0.2     0.0024   17.2   0.2    1.9  2  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.2   1.3e-07    0.0024     180     224 ..       4      48 ..       1      56 [. 0.81
   2 !    1.4   0.0    0.0091   1.6e+02     232     259 .]     100     127 ..      59     127 .. 0.66

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.3e-07
                  SEEEHHHHHHHHHHHHHHHHTTSSGTTTTS.HHHHHHHHHHTTEES CS
  Pkinase_Tyr 180 kkftsksDvWsfGvllwEiftlgespypgl.kneevleklkegkrl 224
                  ++  +  Dv+sf++++wE+f     py++  k ++++e+ +e++rl
   EFC36471.1   4 RQTATMIDVYSFAIIMWEVFF-EVIPYSSSfKLTRMYETNNEEERL 48 
                  5567788*************9.567887766999999998888887 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.0091
                  HHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 232 eelyelmkkcweedpeeRptfselvekl 259
                   +  e++k+ w+++++ R  +s+++++l
   EFC36471.1 100 MKYFEIVKRNWDHNATLRSPISNIRSDL 127
                  4556788899999999999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       366  (0.0204139); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.28s 00:00:00.70 Elapsed: 00:00:00.45
# Mc/sec: 918.06
//
Query:       EFC36472.1  [L=308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00011   22.7   0.0    0.00025   21.6   0.0    1.6  1  Ank_2     Ankyrin repeats (3 copies)
     0.0015   18.8   0.1      0.079   13.5   0.0    3.1  3  Ank_3     Ankyrin repeat
  ------ inclusion threshold ------
      0.025   15.2   0.0      0.066   13.8   0.0    1.8  1  Ank_4     Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.0   4.1e-08   0.00025      12      74 ..     119     199 ..     112     207 .. 0.77

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 4.1e-08
       Ank_2  12 lvklLl..egadpn...k....ngktaLhyAakngnleivklLleh.........adndgrtpLhyAarsghleivklLle 74 
                 + ++Ll  ++a++n   +    +   +L+++ak+g+l+ v+ Ll++         ++++ + p+ +A r+  l+++k L+ 
  EFC36472.1 119 MGEWLLknYKANANeiyTrdswEAYHILYVCAKSGSLDKVRVLLKYgadvnhfskLRYYHEKPISIAFRNEFLNVAKELCG 199
                 568999554455556541567888999*****************97756444544449999**********9*******94 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.13   7.5e+02      17      30 ..     119     132 ..     113     133 .. 0.83
   2 !   13.5   0.0   1.3e-05     0.079       5      31 .]     145     170 ..     142     170 .. 0.92
   3 ?   -2.7   0.0       2.6   1.6e+04       3      23 ..     179     199 ..     177     202 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.13
       Ank_3  17 ivkfLlenkgadvn 30 
                 + ++Ll+n+ a+ n
  EFC36472.1 119 MGEWLLKNYKANAN 132
                 669*******9998 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 1.3e-05
       Ank_3   5 pLhlAarsgnleivkfLlenkgadvna 31 
                 +L+++a+sg+l+ v+ Ll+ +gadvn+
  EFC36472.1 145 ILYVCAKSGSLDKVRVLLK-YGADVNH 170
                 7999*******99******.*****96 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 2.6
       Ank_3   3 etpLhlAarsgnleivkfLle 23 
                 e p+ +A r+  l+++k L+ 
  EFC36472.1 179 EKPISIAFRNEFLNVAKELCG 199
                 678888888888888888865 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.1e-05     0.066       4      52 ..     145     195 ..     141     197 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.1e-05
       Ank_4   4 aLhyaaisgrlelvrlLlekgadinaq..dnrsGetalhiAakrgnveilk 52 
                 +L  +a+sg l+ vr Ll +gad+n+   +  ++e ++ iA ++++++++k
  EFC36472.1 145 ILYVCAKSGSLDKVRVLLKYGADVNHFskLRYYHEKPISIAFRNEFLNVAK 195
                 5667788*******************9544466777777777777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       956  (0.0533214); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.25s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1791.78
//
Query:       EFC36473.1  [L=1005]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.5e-44  150.3   2.0    3.7e-43  147.3   0.9    2.2  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    3.7e-11   43.2   0.2    5.3e-07   29.8   0.0    3.3  3  PAS_9          PAS domain
    4.9e-11   42.6   0.0    2.4e-07   30.8   0.0    2.8  2  PAS            PAS fold
    1.5e-07   31.7   0.0    0.00086   19.5   0.0    2.5  2  PAS_4          PAS fold
    0.00015   21.7   0.0       0.99    9.5   0.0    3.4  3  PAS_8          PAS domain
  ------ inclusion threshold ------
      0.021   15.4   0.0       0.13   12.9   0.0    2.3  2  PAS_10         PAS domain
      0.022   15.1   0.0        0.1   12.9   0.0    2.1  2  PAS_3          PAS fold
       0.16   12.1   0.1       0.52   10.4   0.1    1.9  1  DpaA_N         Dipicolinate synthase subunit A N-terminal dom


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.11   2.4e+02     139     163 ..     172     196 ..     165     203 .. 0.84
   2 !  147.3   0.9   1.6e-46   3.7e-43       5     163 ..     810     970 ..     807     987 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.11
  Guanylate_cyc 139 tgkagkiqvseetyellkeeqfelt 163
                     g +g +++s++t++ll+e+q  + 
     EFC36473.1 172 SGSGGSVEISSSTQQLLDEHQLAFA 196
                    47899*************8887765 PP

  == domain 2  score: 147.3 bits;  conditional E-value: 1.6e-46
  Guanylate_cyc   5 sydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaves..ke 98 
                    ++d++++l++d+vgft++ss++sp++vvk+L ++++ fd++++e +++k+ktiGd+y v+sgl++++++ha ++++ +L+m+ ++++ ++ +   +
     EFC36473.1 810 TIDSCSMLYCDMVGFTDFSSRKSPKDVVKILHDIFTLFDNVCTELNLEKIKTIGDCYFVASGLSKSETNHADNIVKGGLAMIRNMKQYTTYTntDH 905
                    6799*********************************************************************************77776664578 PP

  Guanylate_cyc  99 glkvrvGihtGp.vvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfelt 163
                     l+vr GihtG  v+a v+G++k+ yd++G +v +A  me+tgk +++++s++ty+ l++e  + +
     EFC36473.1 906 LLSVRLGIHTGNdVIAAVVGKVKRTYDLFGPAVEIAQMMEATGKVNQVHISNSTYKELRSE-KSKS 970
                    9**********65999******************************************933.3333 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       2.7   6.1e+03      41      58 ..      74      91 ..       5     104 .. 0.65
   2 !    9.5   0.0    0.0005       1.1       5      51 ..     516     560 ..     513     606 .. 0.82
   3 !   29.8   0.0   2.4e-10   5.3e-07       4     101 ..     676     774 ..     672     776 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.7
       PAS_9 41 vtdpeanerlraaleqgr 58
                 ++++++++lr+++ q++
  EFC36473.1 74 LSNDDDDRELREYIAQKK 91
                446666666666666666 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.0005
       PAS_9   5 lidnpdgrilyaNeaalrllG.yspeevlgksitdlfvtdpeanerlr 51 
                 l+ ++ g i++ N+ a++l+G ys+ + +g ++++lf   ++a  +l+
  EFC36473.1 516 LVFDKLGSIEFLNKEAEDLFGvYSFSA-MGEHVSELF--LDDASVELH 560
                 45458999*************999997.9********..444444443 PP

  == domain 3  score: 29.8 bits;  conditional E-value: 2.4e-10
       PAS_9   4 ilidnpdgril.yaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.....kerevevvlirkngetfwvlltaspvkdddgelvgii 96 
                 ++ +n++g i+  +N+aa   +Gy p+e++g++++ ++  +++++ + + +l++ r+        ++ v   +k+g+ +  ++++s +  d++      
  EFC36473.1 676 VITINDKG-IIqVFNKAASSTFGYEPKEIVGRNVKIIC--NSRDRLKHDSYLDRCRSrengvVDVTRKVKGETKSGKIISLEIKISQIVTDGKPSYV-- 769
                 45588***.888**************************..7777777777777777777788889999999999999999********988776655.. PP

       PAS_9  97 vilrD 101
                 + lrD
  EFC36473.1 770 AYLRD 774
                 66666 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0   0.00073       1.6      12      62 ..     513     563 ..     503     575 .. 0.87
   2 !   30.8   0.0   1.1e-10   2.4e-07       4     101 ..     666     765 ..     663     774 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00073
                 SEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHH CS
         PAS  12 dpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaell 62 
                  p++v D+ g i + N++ae+l+G     ++g+++++l+  + + el++++
  EFC36473.1 513 FPVLVFDKLGSIEFLNKEAEDLFGVYSFSAMGEHVSELFLDDASVELHQAM 563
                 6999***********************************988766777765 PP

  == domain 2  score: 30.8 bits;  conditional E-value: 1.1e-10
                 HHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC..TTSSEEEEEEEEEEEEETT CS
         PAS   4 raileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl..rdgrpihlevraspvrdag 100
                 +ai + ++ p++ ++ +g+i  +N+aa + +G++++e++g+++ +  +  d+ ++ + l ++++  +   ++ +++k   + g++i le+  s ++  g
  EFC36473.1 666 HAITDLSIIPVITINDKGIIQVFNKAASSTFGYEPKEIVGRNVKIICNSRDRLKHDSYLDRCRSRENGVVDVTRKVKGetKSGKIISLEIKISQIVTDG 764
                 577788999***********************************9999999988888888888888888888888888*9********99999888765 PP

                 E CS
         PAS 101 g 101
                 +
  EFC36473.1 765 K 765
                 5 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   3.9e-07   0.00086       5      58 ..     512     565 ..     508     570 .. 0.92
   2 !    9.6   0.0   0.00047         1       6      73 ..     674     741 ..     669     775 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 3.9e-07
       PAS_4   5 pdalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrr 58 
                  ++++v+d+ g ++++N++a++lfg+  ++++G+++ el+ +++  +l++a+ +
  EFC36473.1 512 GFPVLVFDKLGSIEFLNKEAEDLFGVYSFSAMGEHVSELFLDDASVELHQAMYE 565
                 6799***************************************99999999855 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00047
       PAS_4   6 dalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvlegeepiefleell 73 
                  +++ +++ g ++  N+aa + fg++p+e++G+ +  + + +d+  ++++l+r+ + e  + +++  +
  EFC36473.1 674 IPVITINDKGIIQVFNKAASSTFGYEPKEIVGRNVKIICNSRDRLKHDSYLDRCRSRENGVVDVTRKV 741
                 689999****************************9999999999999999998877777666665555 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0   0.00044      0.99      13      37 ..     514     539 ..     508     560 .. 0.77
   2 ?    0.1   0.0      0.39   8.7e+02      28      57 ..     561     595 ..     561     605 .. 0.71
   3 !    6.8   0.0    0.0031       6.9      12      56 ..     674     719 ..     664     730 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00044
       PAS_8  13 giavvd.lgdrivdvNqaalellG.ys 37 
                 +++v+d lg  i + N+ a++l+G ys
  EFC36473.1 514 PVLVFDkLGS-IEFLNKEAEDLFGvYS 539
                 7999999999.*************444 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.39
       PAS_8  28 qaalellGys...adlkgellg...qllpvlrplle 57 
                 qa++e+lG +     lk++++g   ++l++++p+ +
  EFC36473.1 561 QAMYEFLG-PtenSTLKADKIGsdqNYLDDIKPYSQ 595
                 89******.436766777777655688888887766 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0031
       PAS_8  12 dgiavvdlgdrivd.vNqaalellGys.adlkgellgqllpvlrpll 56 
                  +++ +++ + i++  N+aa   +Gy+ +++ g  + ++ +  + l+
  EFC36473.1 674 IPVITINDKG-IIQvFNKAASSTFGYEpKEIVGRNVKIICNSRDRLK 719
                 4777777666.88889*****************99955555544444 PP

>> PAS_10  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       2.2     5e+03      14      90 ..     517     595 ..     511     601 .. 0.63
   2 ?   12.9   0.0   5.7e-05      0.13      10      81 ..     674     751 ..     668     760 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.2
      PAS_10  14 flDdnlqirrFtpaakklfklip.advGrpladihpkkavknveevi.ealrtgekdevevvvpkngkwvlvrylpyrd 90 
                  +D+   i + +++a+ lf + + + +G++++++  ++a  ++ + + e l  +e+ + +     +++ +l  ++py +
  EFC36473.1 517 VFDKLGSIEFLNKEAEDLFGVYSfSAMGEHVSELFLDDASVELHQAMyEFLGPTENSTLKADKIGSDQNYLDDIKPYSQ 595
                 5666667777777777777765537888888888766555555444404444455544444434778888889999876 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 5.7e-05
      PAS_10  10 ieltflDdnlqirrFtpaakklfklipad.vGrpladihpkkavknveeviealrtgekdevevvvp.....kngkwv 81 
                 i ++ ++d+  i  F++aa++ f + p++ vGr+++ i +++   +  + ++++r++e+ +v+v ++     k+gk++
  EFC36473.1 674 IPVITINDKGIIQVFNKAASSTFGYEPKEiVGRNVKIICNSRDRLKHDSYLDRCRSRENGVVDVTRKvkgetKSGKII 751
                 7789999*****************9987648**********999999************9999999843444445555 PP

>> PAS_3  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   4.6e-05       0.1       5      85 ..     689     769 ..     686     771 .. 0.89
   2 ?   -2.3   0.0       2.6   5.8e+03       5      31 ..     815     841 ..     813     842 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.6e-05
       PAS_3   5 serveeilGyspeellgkveswldlvhpeDrervrealqeal..kkge.pyegeyRirrkdGeyrwveararvirdengkpvrv 85 
                 +++ + ++Gy+p e+ g+  +++ ++   Dr +  + l+++   ++g  +++  ++  +k+G+++ +e +++ i   +gkp +v
  EFC36473.1 689 NKAASSTFGYEPKEIVGR--NVKIICNSRDRLKHDSYLDRCRsrENGVvDVTRKVKGETKSGKIISLEIKISQI-VTDGKPSYV 769
                 7788999***********..*******************9996566667788889999************9999.999999876 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2.6
       PAS_3   5 serveeilGyspeellgkveswldlvh 31 
                 s  +++++G+++ + +++++++ +++h
  EFC36473.1 815 SMLYCDMVGFTDFSSRKSPKDVVKILH 841
                 556899*****9999999999999999 PP

>> DpaA_N  Dipicolinate synthase subunit A N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.1   0.00023      0.52      15      72 ..     634     689 ..     630     711 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00023
                 HHHHHHTT-EEEEES-TSSS-BTTEEEE-GGGS-GGG-SEEE--TT-BETTTEE-BSS CS
      DpaA_N  15 arkLaekgakvslygleleekiegvekaesleealedadviilPvpgtkdggeintpf 72 
                 ++kL+e  + v+l  +++ ++ ++++ ++s++ a+  +d+ i Pv  ++d+g i+  +
  EFC36473.1 634 IKKLQEIHFCVYLKFFKEIDNEHQAAVTNSFKHAI--TDLSIIPVITINDKGIIQVFN 689
                 799*******************************9..9999***********998744 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1005 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       962  (0.0536561); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.76u 0.30s 00:00:01.06 Elapsed: 00:00:00.47
# Mc/sec: 6494.33
//
Query:       EFC36474.1  [L=191]
Description: DnaJ domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.3e-08   33.5   0.8    0.00069   19.7   0.1    2.5  2  DnaJ             DnaJ domain
    0.00078   17.6   1.7    0.00078   17.6   1.7    2.0  2  Prominin         Prominin
     0.0027   16.6   0.2     0.0034   16.2   0.2    1.1  1  DUF2207          Predicted membrane protein (DUF2207)
  ------ inclusion threshold ------
      0.013   15.7   0.8       0.27   11.4   0.1    2.5  2  SANT_DAMP1_like  SANT/Myb-like domain of DAMP1
      0.013   15.1   0.2      0.017   14.7   0.2    1.2  1  DUF368           Domain of unknown function (DUF368)
      0.051   14.0   0.1        8.4    7.3   0.0    2.6  2  SRR              Seven Residue Repeat
      0.051   14.2   0.7       0.14   12.9   0.2    1.9  1  DUF573           Protein of unknown function, DUF573
      0.066   11.7   2.8        0.1   11.1   2.0    1.6  1  Baculo_F         Baculovirus F protein
      0.088   12.7   3.3        1.2    9.0   3.3    2.0  1  Sigma70_ner      Sigma-70, non-essential region
       0.15   11.9   1.1       0.22   11.4   0.5    1.6  2  ECSCR            Endothelial cell-specific chemotaxis regulat
       0.39   10.0   3.2          1    8.7   1.6    2.0  2  SLATT_5          SMODS and SLOG-associating 2TM effector doma
        1.2    9.2   5.3        2.3    8.3   5.3    1.5  1  LSR              Lipolysis stimulated receptor (LSR)
          7    6.6  10.7        4.2    7.3   0.0    3.2  3  DUF4006          Family of unknown function (DUF4006)


Domain annotation for each model (and alignments):
>> DnaJ  DnaJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.1   0.00012      0.17       1      24 [.      21      44 ..      21      52 .. 0.90
   2 !   19.7   0.1     5e-07   0.00069      40      63 .]      80     103 ..      72     103 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00012
                HHHHHHTSSTTG-HHHHHHHHHHH CS
        DnaJ  1 dyYeiLgvskdasedeIkkaYrkl 24
                d+Y++L ++++a+ +eI +++++ 
  EFC36474.1 21 DFYSVLDLTRSATIEEINEKFKTV 44
                79******************9976 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 5e-07
                 HHHHHHHHHHHHHHTSHHHHHHHH CS
        DnaJ  40 eekFkeineAyevLsdpekRkqYD 63 
                 +e++ ++++Aye+Lsdp+++++YD
  EFC36474.1  80 TEQYSQMTKAYETLSDPTRKQIYD 103
                 7899*******************9 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.7     0.041        56     560     619 ..      26      85 ..       8     104 .. 0.58
   2 !   17.6   1.7   5.6e-07   0.00078     464     517 ..     129     187 ..     127     191 .] 0.89

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.041
    Prominin 560 eellnikklteeiqkelenlkvdlsnlelLteeer.kdLeklresglskihsslyleqlck 619
                  +l++   + eei+++++ +k+  ++++ L ++e  ++ e+l + g ++ ++sl++eq ++
  EFC36474.1  26 LDLTRSATI-EEINEKFKTVKERYEQIQSLVQDESpQSDETLTQFGFNRSDFSLLTEQYSQ 85 
                 333333222.466666666666666665444443325556666666666666666666554 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 5.6e-07
    Prominin 464 LlvgvglsFlffsllmlvv..lltFlvGlnvyklvCepl...esneLfrvlDtpgllpe 517
                 Llvg g++F+++++lm++v  ll+Fl Gl++    C +    +s e+ ++lD +++l++
  EFC36474.1 129 LLVGYGIAFVVIAFLMVIVgiLLIFLFGLIIWAFCCVSSkhsNSLEIPKQLDHSKVLEK 187
                 99**************99877899**************9977777888****9988875 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.2   2.4e-06    0.0034     311     426 ..      56     164 ..      11     172 .. 0.57

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 2.4e-06
     DUF2207 311 ndeeldpyEkalldlLfdkseegkslkeikkyakkskkkakkfkkalkkwksavkk.......kergyfdkkgkkklkklsalglgliilglilillal 402
                 + +e ++++++l ++ f+ s           ++++  + ++++ ka++ + +  +k       +   y++k+  +k   l +l  +l+  g++++++a 
  EFC36474.1  56 Q-DESPQSDETLTQFGFNRS-----------DFSLLTEQYSQMTKAYETLSDPTRKqiydqffRIGIYLRKEWGWKEEDLEFLFNLLVGYGIAFVVIA- 141
                 2.222667777777777333...........3333344777777777777777777888888877777777777777777777666666666655433. PP

     DUF2207 403 lllvlllvfllilllillliaiiv 426
                 +l+v+ + +lli+l++l++ a+++
  EFC36474.1 142 FLMVI-VGILLIFLFGLIIWAFCC 164
                 33333.444444444444444443 PP

>> SANT_DAMP1_like  SANT/Myb-like domain of DAMP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1      0.15   2.1e+02      55      78 ..      23      47 ..      11      53 .. 0.75
   2 ?   11.4   0.1    0.0002      0.27      20      52 ..     102     141 ..      74     142 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.15
  SANT_DAMP1_like 55 yelek.kkkrsledlkeryYsvark 78
                     y++ + +++ ++e++ e++ +v+++
       EFC36474.1 23 YSVLDlTRSATIEEINEKFKTVKER 47
                     4444456778899999988888766 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.0002
  SANT_DAMP1_like  20 Yeellke.....ed..WtkeetdyLfdlckeydlrfvvia 52 
                      Y+++ +      ++  W++e+ + Lf+l+  y + fvvia
       EFC36474.1 102 YDQFFRIgiylrKEwgWKEEDLEFLFNLLVGYGIAFVVIA 141
                      5555444444432234**********************96 PP

>> DUF368  Domain of unknown function (DUF368)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.2   1.3e-05     0.017      44     106 ..     113     170 ..      77     183 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.3e-05
      DUF368  44 rlkaalkkinlkfLlalvlGivvsilvlakllsyllekypillwslffGlilasvvvlikevk 106
                 r +  +k+ +l+fL+ l++G  ++++v+a l+ ++      +l  ++fGli+ ++++++++ +
  EFC36474.1 113 RKEWGWKEEDLEFLFNLLVGYGIAFVVIAFLMVIV-----GILLIFLFGLIIWAFCCVSSKHS 170
                 44556899*****************9988666543.....4677799*****99998887655 PP

>> SRR  Seven Residue Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.0    0.0061       8.4       1      14 []      39      52 ..      39      52 .. 0.90
   2 ?    4.3   0.0     0.061        85       1      14 []      81      94 ..      81      94 .. 0.90

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0061
         SRR  1 enfekVknaYeqLs 14
                e+f+ Vk+ Yeq++
  EFC36474.1 39 EKFKTVKERYEQIQ 52
                69**********85 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.061
         SRR  1 enfekVknaYeqLs 14
                e++ +++ aYe+Ls
  EFC36474.1 81 EQYSQMTKAYETLS 94
                68999*******97 PP

>> DUF573  Protein of unknown function, DUF573
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.2   9.9e-05      0.14      14      77 ..       4      61 ..       1      76 [. 0.68

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 9.9e-05
      DUF573 14 LqglldfksktgtspksdldafyeavksslssdvsksqlseKlrrLkkkyrnavskikkgkdps 77
                L  l++++ ++ +   +++++fy  +  + s  ++ +++ eK +++k++y++++s ++ ++ p+
  EFC36474.1  4 LVVLVSSSFQQDE---EETSDFYSVLDLTRS--ATIEEINEKFKTVKERYEQIQSLVQ-DESPQ 61
                5555555444444...588888888875555..999****************998763.33333 PP

>> Baculo_F  Baculovirus F protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   2.0   7.4e-05       0.1     519     596 ..      83     170 ..      40     189 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 7.4e-05
    Baculo_F 519 hknLkelterlkdlrkrmnnntvfkgdei.......ddnsnsnwysnlvnw...wheikviviaivllllllvvlkiykccckgscsk 596
                 ++++++ +e+l+d +++   ++ f++  +       ++++ + +++ lv +   ++ i ++++++ +ll++l++l i  +cc +s+ +
  EFC36474.1  83 YSQMTKAYETLSDPTRKQIYDQFFRIGIYlrkewgwKEEDLEFLFNLLVGYgiaFVVIAFLMVIVGILLIFLFGLIIWAFCCVSSKHS 170
                 44555555555555444444444444333222225455666667777777799999***********************887766544 PP

>> Sigma70_ner  Sigma-70, non-essential region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   3.3   0.00085       1.2      56     102 ..      20      66 ..       8     108 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00085
  Sigma70_ner  56 eeeseseaadeeelkeealekfeelreqyeklrkalkkkgrkskkye 102
                  ++  + ++  +++  ee+ ekf++++e ye+++ ++++++ +s+++ 
   EFC36474.1  20 SDFYSVLDLTRSATIEEINEKFKTVKERYEQIQSLVQDESPQSDETL 66 
                  3456677888889999******************9999977665554 PP

>> ECSCR  Endothelial cell-specific chemotaxis regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       6.9   9.6e+03      40      50 ..       3      13 ..       2      21 .. 0.60
   2 ?   11.4   0.5   0.00016      0.22      23      64 ..     135     177 ..     129     189 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 6.9
       ECSCR 40 ilvsvvslrfk 50
                ilv +vs  f+
  EFC36474.1  3 ILVVLVSSSFQ 13
                55666666555 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00016
       ECSCR  23 aafgvisfivilv.vvviilvsvvslrfkcrknkesedpqkpe 64 
                  af vi+f++++v +++i l  ++   f c   k s+  + p+
  EFC36474.1 135 IAFVVIAFLMVIVgILLIFLFGLIIWAFCCVSSKHSNSLEIPK 177
                 599*****988772556778899999*****999998765554 PP

>> SLATT_5  SMODS and SLOG-associating 2TM effector domain family 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.3      0.15   2.1e+02      94     132 ..      12      51 ..       6      57 .. 0.76
   2 ?    8.7   1.6   0.00074         1     117     189 ..      78     151 ..      38     162 .. 0.69

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.15
     SLATT_5  94 fhkcaleLselynelrllli.seedlkekykeiskeYeei 132
                 f++   e s++y+ l l ++ + e+ +ek k+++++Ye+i
  EFC36474.1  12 FQQDEEETSDFYSVLDLTRSaTIEEINEKFKTVKERYEQI 51 
                 5555566677777777766677888999999999999998 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00074
     SLATT_5 117 dlkekykeiskeYeeiLdkyeNHdeiDyklfraknakkseelekskklkwfl...rrylivifllylliillpvil 189
                  l+e+y ++ k Ye++ d  + +++i+ ++fr+     +e+ +k++ l++++   + y i ++++++l++++ ++l
  EFC36474.1  78 LLTEQYSQMTKAYETLSD--PTRKQIYDQFFRIGIYLRKEWGWKEEDLEFLFnllVGYGIAFVVIAFLMVIVGILL 151
                 467888888899998877..6799**********999999999999999999666333333444444444443333 PP

>> LSR  Lipolysis stimulated receptor (LSR)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   5.3    0.0017       2.3       6      28 ..     142     165 ..     136     169 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0017
         LSR   6 vlvvlgalllllLiG.iCwCqCCP 28 
                  l+v+ ++ll+ L+G i w  CC 
  EFC36474.1 142 FLMVIVGILLIFLFGlIIWAFCCV 165
                 466777778888888579*****6 PP

>> DUF4006  Family of unknown function (DUF4006)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.0    0.0031       4.2      25      62 ..       1      38 [.       1      42 [. 0.80
   2 ?   -0.8   0.1       1.1   1.5e+03      39      52 ..      82      96 ..      77     103 .. 0.74
   3 ?    2.0   4.0      0.14   1.9e+02      17      37 ..     143     163 ..     125     189 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0031
     DUF4006 25 LsilavLtvlaikvqqaeatnyYkledldsvkmiskdn 62
                +sil+vL+  + + +++e  ++Y++ dl     i++ n
  EFC36474.1  1 MSILVVLVSSSFQQDEEETSDFYSVLDLTRSATIEEIN 38
                59**********************87776555555444 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.1
     DUF4006 39 qqaeatnyYk.ledl 52
                q +++t+ Y+ l+d+
  EFC36474.1 82 QYSQMTKAYEtLSDP 96
                77899****955555 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.14
     DUF4006  17 mliavvLLLsilavLtvlaik 37 
                 ++++v +LL  l++L ++a  
  EFC36474.1 143 LMVIVGILLIFLFGLIIWAFC 163
                 578888999999999999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2140  (0.11936); expected 358.6 (0.02)
Passed bias filter:                     1105  (0.061632); expected 358.6 (0.02)
Passed Vit filter:                       163  (0.00909142); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 1170.80
//
Query:       EFC36475.1  [L=293]
Description: mitochondrial ADP/ATP-transporter [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.7e-34  117.6   1.2    1.1e-13   50.8   0.0    3.1  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.0   1.1e-08   0.00019       4      81 ..       7      93 ..       4     103 .. 0.81
   2 !   43.1   0.1   1.7e-15     3e-11       5      89 ..     117     199 ..     114     203 .. 0.92
   3 !   50.8   0.0   6.3e-18   1.1e-13       9      89 ..     213     291 ..     206     293 .] 0.83

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 1.1e-08
                HHHHHHHHHHHHHHHHHHHH....HHHHHHHHHHHHCCCSSTTTSCSS.....HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHH CS
   Mito_carr  4 svlkellaGglagavatlvt....tPldvvKtrlqtqkksskksksaa.....ildvlkkiykeeGlrglyrGllpnllrvapasal 81
                s+l ++ +G +a++ ++l++    +Pl ++ + lq+++  ++ +k+ +     ++ +l++i +++G+++ +rG+ + ll+++ + + 
  EFC36475.1  7 SPLVQVTVGIVAKVSSSLLVklpiCPLFTAACILQSHQADHQLAKQIGdkqlnTITILQQIKQDQGISSWFRGFPVELLKNILTGMF 93
                5677888888888888877544449***********88887665554468899***************************9987665 PP

  == domain 2  score: 43.1 bits;  conditional E-value: 1.7e-15
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetl 89 
                 +l++++ G+l g++   +t Pl +v+ +l  +   +++  +++ +dvlkk+++++G ++l+ Gl ++l++ +++++ +fv+y+ l
  EFC36475.1 117 YLRNVVGGALIGTAMEALTRPLAYVRFKLAFDTIGKRQ--YSGPIDVLKKTIETNGYSALFVGLDASLIKLIVYRFSYFVMYDIL 199
                 7899**************************99988655..667***************************************986 PP

  == domain 3  score: 50.8 bits;  conditional E-value: 6.3e-18
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   9 llaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetl 89 
                 +l++ l    + l+++Pl++v  +lq+q+++++k+ s ++ld+++k+ykeeG++g++rG+ +++  +  a +  f ly+ +
  EFC36475.1 213 FLIAQLISFSNFLICYPLETVERKLQVQADKKEKTFS-GTLDCFQKTYKEEGISGFFRGWKISIATSL-AISGGFILYDLI 291
                 55666666677799*****************998665.5************************99877.666667777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1850.92
//
Query:       EFC36476.1  [L=390]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.2e-35  119.5   0.2    5.2e-35  119.5   0.2    2.0  2  YchF-GTPase_C  Protein of unknown function (DUF933)
    5.1e-22   78.1   0.0      1e-21   77.1   0.0    1.7  1  MMR_HSR1       50S ribosome-binding GTPase
    6.7e-07   29.0   0.0    2.2e-06   27.3   0.0    1.9  2  FeoB_N         Ferrous iron transport protein B
  ------ inclusion threshold ------
       0.02   13.9   0.0      0.046   12.7   0.0    1.6  1  MeaB           Methylmalonyl Co-A mutase-associated GTPase Me
      0.086   13.4   0.0        2.1    8.9   0.0    2.3  2  ABC_tran       ABC transporter
       0.12   13.2   0.1          8    7.4   0.0    2.4  2  ATP-synt_G     Mitochondrial ATP synthase g subunit


Domain annotation for each model (and alignments):
>> YchF-GTPase_C  Protein of unknown function (DUF933)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       2.2   6.6e+03      53      72 ..     177     196 ..     165     199 .. 0.62
   2 !  119.5   0.2   1.7e-38   5.2e-35       1      84 []     300     382 ..     300     382 .. 0.98

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.2
  YchF-GTPase_C  53 gseaaakeagklrlegkdyv 72 
                    ++  a+++a  + +egk++ 
     EFC36476.1 177 SELVAVEKALEMLKEGKEVR 196
                    34556677777777777765 PP

  == domain 2  score: 119.5 bits;  conditional E-value: 1.7e-38
  YchF-GTPase_C   1 LitffTaGekevraWtikkgttapqaAgviHsDfekgFiraevikyedlvelgseaaakeagklrlegkdyvvqdgDiilfkfN 84 
                    Li++fT+G+  vr Wtik+g++ap aAg+iHsDfekgFi+ ev+++ed++++gse+++k++gkl+ +gk+y v+dgDi++fkfN
     EFC36476.1 300 LINYFTCGQ-HVRTWTIKRGMKAPAAAGQIHSDFEKGFICVEVMSFEDYKQYGSESECKNNGKLKEKGKTYEVEDGDILHFKFN 382
                    89******6.7************************************************************************9 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.1   0.0   3.5e-25     1e-21       1     100 [.      22     146 ..      22     225 .. 0.84

  Alignments for each domain:
  == domain 1  score: 77.1 bits;  conditional E-value: 3.5e-25
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEE.................EEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEE CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgke.................ielvDtpGliegaseekglgkaflalee.adlill 81 
                 +++ivG pNvGKSt++n lt++ + ++++p++T+d+ + +v++ +++                 ++++D++Gl+++ase++glg+afl++++ +d+i++
  EFC36476.1  22 NIGIVGLPNVGKSTFFNILTNSSVPAENFPFCTIDPSTSHVAVPDERydwlvkhlgatdnapaiLNVTDIAGLVKNASEGEGLGNAFLSHIRaVDAIFH 120
                 599**************************************95554467888888888888899****************************55***** PP

                 EEETT........TTCSHHHHHHHHHH CS
    MMR_HSR1  82 vvdas........eeklkpldeeleel 100
                 +v+          e++++p+ ++++ +
  EFC36476.1 121 MVRTFesknithvEGSIDPV-RDIKTI 146
                 **966755554442233333.344333 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.0   7.4e-10   2.2e-06       2      47 ..      22      67 ..      21      75 .. 0.89
   2 ?   -2.5   0.0       1.1   3.3e+03     106     148 ..     217     266 ..     210     272 .. 0.50

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 7.4e-10
                EEEEEESTTSSHHHHHHHHHTTSEEEEESTTSSSEEEEEEEEETTE CS
      FeoB_N  2 tvalvGnpnvGkttlfnaltgakqkvgNwpGvtvekkegklklkgk 47
                ++ +vG pnvGk+t+fn lt+++    N+p  t++ ++ ++ + ++
  EFC36476.1 22 NIGIVGLPNVGKSTFFNILTNSSVPAENFPFCTIDPSTSHVAVPDE 67
                5889*******************************99988876665 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.1
                 SSEEEEEETH..HHH..HHTT..EEE-HHHH.HHHHTS-EEEEBTTTTBT CS
      FeoB_N 106 vpvvlalnmi..dea..ekkg..ieidlkkL.sekLgvpvvktsakkkeg 148
                 +p++  +nm+  d++  ek++  i+i +    ++++  pv++ sa+ +++
  EFC36476.1 217 KPMIYLVNMTpkDVVdpEKNEhvIKIREYVTsKSAIAEPVIPYSAAFEKK 266
                 66777777753333311222211333333221345666777777766655 PP

>> MeaB  Methylmalonyl Co-A mutase-associated GTPase MeaB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.5e-05     0.046      23      68 ..      14      58 ..       3      63 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.5e-05
                GGG-S-SEEEEEEE-TTSSHHHHHHHHHHHHHCTT--EEEEEE--- CS
        MeaB 23 lakaGraqvvGltGvPGaGkstlvealglelrrrGkrvavlavDPs 68
                + + G    +G+ G+P +Gkst+ + l+ + +   +      +DPs
  EFC36476.1 14 FGRVGTNLNIGIVGLPNVGKSTFFNILTNSSVP-AENFPFCTIDPS 58
                56789999****************999876554.345566666665 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.0   0.00071       2.1      13      39 ..      22      48 ..      11      89 .. 0.90
   2 ?    2.3   0.1     0.077   2.3e+02      38      93 ..     133     190 ..     117     249 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00071
                EEEEEESTTSSHHHHHHHHTTSS--SE CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran 13 kvaivGenGaGKStLlkllagllkpte 39
                 ++ivG    GKSt++++l++ + p+e
  EFC36476.1 22 NIGIVGLPNVGKSTFFNILTNSSVPAE 48
                689*****************9988765 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.077
                 SEEEEEET.TCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHHHHHTC...HHHHHHHST CS
                 xxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxx RF
    ABC_tran  38 teGeilld.gkdlkeqeleslrkeigvlpqepqlfpeltvrenesdee...iekalsklg 93 
                  eG+i  d  +d+k++e e  +k i++l+  +   +++  +++e+ +e   +ekal+ l+
  EFC36476.1 133 VEGSI--DpVRDIKTIEQELIKKDISYLENVKGPLEKMGKQKKEKASElvaVEKALEMLK 190
                 56776..55688888999999999999998866666664444444444333444444443 PP

>> ATP-synt_G  Mitochondrial ATP synthase g subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.047   1.4e+02      20      73 ..     126     178 ..     114     189 .. 0.82
   2 ?    7.4   0.0    0.0027         8      30      89 ..     252     308 ..     230     311 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.047
  ATP-synt_G  20 lskqvakkeklapPtvaefqslykqllktalaspskpqellerlknlkkeeall 73 
                 +sk++ ++e+  +P v +++++ ++l+k+ +++ ++ +  le++ + kke+a  
  EFC36476.1 126 ESKNITHVEGSIDP-VRDIKTIEQELIKKDISYLENVKGPLEKMGKQKKEKASE 178
                 68999999988888.9***************99998888888888888877755 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0027
  ATP-synt_G  30 lapPtvaefqslykqllktalaspskpqellerlknlkkeeallagvvaaevlgfFsvGE 89 
                 +a P +    ++ k++++t  ++  k+qel+++  n k++++++ g  ++ ++ +F+ G 
  EFC36476.1 252 IAEPVIPYSAAFEKKWQET-DEE--KRQELIKKGINSKMADIIKIGYAMLNLINYFTCGQ 308
                 4555555555555555555.333..4589****************************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (390 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       840  (0.0468515); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2293.22
//
Query:       EFC36477.1  [L=1089]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.3e-12   46.4   0.0    2.2e-08   34.1   0.0    2.6  2  PAS        PAS fold
    2.4e-10   40.6   1.1    5.1e-07   29.9   0.2    3.0  3  PAS_9      PAS domain
    4.3e-07   29.7   0.0    9.4e-07   28.5   0.0    1.5  1  Cellulase  Cellulase (glycosyl hydrolase family 5)
    6.8e-07   29.5   0.0    0.00081   19.6   0.0    2.4  2  PAS_4      PAS fold
     0.0019   18.7   0.2      0.079   13.6   0.2    3.1  3  PAS_10     PAS domain
     0.0067   16.4   0.0        1.3    9.2   0.0    3.1  3  PAS_8      PAS domain


Domain annotation for each model (and alignments):
>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0   0.00031      0.94       9      62 ..     392     445 ..     384     458 .. 0.84
   2 !   34.1   0.0   7.4e-12   2.2e-08       5     112 ..     549     656 ..     545     657 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00031
                 HSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHH CS
         PAS   9 slpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaell 62 
                 +   p++v D+ g i y N++ae+l+G     +lg+++++l+  + + el++++
  EFC36477.1 392 TCGFPVLVFDKLGSIEYLNKEAEDLFGVFSFSALGEHVSELFLDDASVELHQAI 445
                 56789**********************************999988776888776 PP

  == domain 2  score: 34.1 bits;  conditional E-value: 7.4e-12
                 HHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC..TTSSEEEEEEEEEEEEETTE CS
         PAS   5 aileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl..rdgrpihlevraspvrdagg 101
                 a+ e ++ p++ ++ +g+i  +N+aa + +G++++ev+g+++ +  + +d+ ++ + le++    ++  ++ +++k   + g++i +e+r+s+++  g+
  EFC36477.1 549 AVTEMITIPVITINDKGIIQVFNKAASSTFGFEAKEVVGRNVKIICNKKDRLKHDSYLEKCKTKDKNTLNMVKKVKGetKSGKIISVEIRVSHILKDGK 647
                 56667889************************************999999885555555555555555555555555999**************99988 PP

                 EEEEEEEEEEE CS
         PAS 102 eilgflgvlrd 112
                     ++  +rd
  EFC36477.1 648 S--SYIAYIRD 656
                 6..77766666 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0         6   1.8e+04      42      59 ..      70      87 ..      56     101 .. 0.72
   2 !    8.0   0.0    0.0011       3.3       5      50 ..     398     441 ..     395     503 .. 0.81
   3 !   29.9   0.2   1.7e-10   5.1e-07       4     101 ..     558     656 ..     555     658 .. 0.78

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 6
       PAS_9 42 tdpeanerlraaleqgrk 59
                +++e+++ l+++l+++++
  EFC36477.1 70 DEDEDEKALQEFLQAKKS 87
                678888888888888885 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0011
       PAS_9   5 lidnpdgrilyaNeaalrllG.yspeevlgksitdlfvtdpeanerl 50 
                 l+ ++ g i+y N+ a++l+G +s+ + lg ++++lf   ++a  +l
  EFC36477.1 398 LVFDKLGSIEYLNKEAEDLFGvFSFSA-LGEHVSELF--LDDASVEL 441
                 45458999*************888776.9********..33333333 PP

  == domain 3  score: 29.9 bits;  conditional E-value: 1.7e-10
       PAS_9   4 ilidnpdgril.yaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk....kerevevvlirkngetfwvlltaspvkdddgelvgiiv 97 
                 ++ +n++g i+  +N+aa   +G+ ++ev+g++++ ++ +++++ +  + + + ++k        + v   +k+g+ + v++++s++  d++      +
  EFC36477.1 558 VITINDKG-IIqVFNKAASSTFGFEAKEVVGRNVKIIC-NKKDRLKHDSYLEKCKTKdkntLNMVKKVKGETKSGKIISVEIRVSHILKDGKSSYI--A 652
                 55578***.888**************************.444444444444444443667988999999******************877655444..7 PP

       PAS_9  98 ilrD 101
                  +rD
  EFC36477.1 653 YIRD 656
                 7777 PP

>> Cellulase  Cellulase (glycosyl hydrolase family 5)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5   0.0   3.1e-10   9.4e-07      32     250 ..     664     889 ..     650     912 .. 0.68

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 3.1e-10
                 HHT-SEEEEEEECTGGTTSSTTTGCTHHHHHHHHHHHHHHHHTT-EE..EEEEESSTTTCSSSSTTTTHHHHHHHHHHHHHHHHHHHTTTTTTEEEESS CS
   Cellulase  32 dagfntvRlpvswgelvenapdykvdenslerveevvkyakenglyv..ildiHseegwltkadgnssedtaeeffkklwtqiAerykkndevvifelm 128
                 + gf  +R+ + w +  ++++ y     +++++++++ + k +gl++  il + +  ++  +a++ +++d a e f+++ ++ A++y   +e+vife++
  EFC36477.1 664 AGGFSWIRMDLFWSSVETTKQVY-----NFASYDTLLTALKLRGLKAlfILTYSN-TLYTGSASTPPTTDIAIEAFANYSRAAAKHY--ANENVIFEVY 754
                 56999********6666555555.....9*****************975555555.46777777778888899**************..999******* PP

                 SS--STTCTCCTCHHHTTHHHHHHHHHHHHHHHHTTSSEEEEECHH.HHT......BHHHHHCTSGSSSSTTEEEEEEEETTTHHHTGCGS........ CS
   Cellulase 129 NEPhgnntgaewtseeadevkayaeeaikaIRavgpnrliivegns.wsg......nldgavlndPndsqdnliysvHfYgpsdfaqtefg........ 212
                 NE   ++        +  + +a+ ++a++aIR+ +pn  +   g+  +s         +g ++   n sq    + +H Yg     +  fg        
  EFC36477.1 755 NEADLQGF-------TPVTYAALSKAAVAAIREGNPNAQVSTTGVAgFSYtfvrgfTSEG-GAASKNGSQLFSGIGLHPYGVGSP-KSPFGrfpdltrk 844
                 ***99443.......345779999*************66655554432223333332222.222334455566666676663332.2222256666666 PP

                 .......HSCTHHHHHHHHHHHHHHHHHHTTSEEEEEEEESSTTS CS
   Cellulase 213 .......kdltdktnlaqrledaakylvekgipviigEfGgsnad 250
                        +   + +  a++l++a+k+l +   pv+ +E+G++ +d
  EFC36477.1 845 frsiindNINATLQGKASTLTSAQKSLISTVPPVWDTEWGLTATD 889
                 666665444444444556666666666666666666666666444 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   2.7e-07   0.00081       6      56 ..     395     445 ..     392     450 .. 0.92
   2 !    7.2   0.0     0.002         6       6      85 ..     556     639 ..     552     657 .. 0.74

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 2.7e-07
       PAS_4   6 dalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleral 56 
                 ++++v+d+ g ++y+N++a++lfg+  +++lG+++ el+ +++  +l++a+
  EFC36477.1 395 FPVLVFDKLGSIEYLNKEAEDLFGVFSFSALGEHVSELFLDDASVELHQAI 445
                 689**************************************9888888876 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.002
       PAS_4   6 dalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvlegeepiefleelll....pgeerhyelrl 85 
                  +++ +++ g ++  N+aa + fg++++e++G+ +  + ++ d+  ++++l+++ + ++    +   +     +g+   +e+r+
  EFC36477.1 556 IPVITINDKGIIQVFNKAASSTFGFEAKEVVGRNVKIICNKKDRLKHDSYLEKCKTKDKNTLNMVKKVKgetkSGKIISVEIRV 639
                 578999***************************999999999999999998888776665444444444455555555555555 PP

>> PAS_10  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.38   1.1e+03      11      90 ..     396     477 ..     390     482 .. 0.71
   2 !   13.6   0.2   2.7e-05     0.079       8      85 ..     554     637 ..     548     645 .. 0.84
   3 ?   -0.8   0.0       0.8   2.4e+03      22      90 ..     985    1051 ..     982    1054 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.38
      PAS_10  11 eltflDdnlqirrFtpaakklfkl.ipadvGrpladihpkkavknveevi.ealrtgekdevevvvpkngkwvlvrylpyrd 90 
                  ++ +D+   i + +++a+ lf +   + +G++++++  ++a  ++ + i e l  +e+ + +     +++ +l  ++py++
  EFC36477.1 396 PVLVFDKLGSIEYLNKEAEDLFGVfSFSALGEHVSELFLDDASVELHQAIyEFLGPTENSTLKADKIGSDQNYLDDIRPYNQ 477
                 667788888999999999999875156899*****99877666666555505555555555554444889999999999976 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 2.7e-05
      PAS_10   8 tpieltflDdnlqirrFtpaakklfklipad.vGrpladihpkkavknveeviealrtgekdevevvvp.....kngkwvlvry 85 
                 + i ++ ++d+  i  F++aa++ f + +++ vGr+++ i +kk   +  + +e+++t+ k++ ++v +     k+gk++ v++
  EFC36477.1 554 ITIPVITINDKGIIQVFNKAASSTFGFEAKEvVGRNVKIICNKKDRLKHDSYLEKCKTKDKNTLNMVKKvkgetKSGKIISVEI 637
                 6799999*******************9987537**********999999************99998887445556667666665 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.8
      PAS_10   22 rrFtpaakklfklipadvGrpladihpkkavknveeviealrtgekdevevvvpkngkwvlvrylpyrd 90  
                  +rF+ + ++++ l p+++G +++ i + ++ ++v +++ +  t  kd+  +v +++g +++  + p+ +
  EFC36477.1  985 MRFKSSNDSVIVLLPTETGASVN-I-KANSASSVVDIFGRNVTVSKDNTFTVKETEGLVYVTFVTPMVT 1051
                  68999999999999999999985.5.3466677777777777777777777777888888888888766 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0   0.00042       1.3      13      37 ..     396     420 ..     392     453 .. 0.76
   2 ?   -1.9   0.0       1.2   3.6e+03      28      57 ..     443     477 ..     443     486 .. 0.69
   3 ?    3.4   0.0     0.028        83       5      47 ..     549     592 ..     545     608 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00042
       PAS_8  13 giavvd.lgdrivdvNqaalellGys 37 
                 +++v+d lg  i + N+ a++l+G+ 
  EFC36477.1 396 PVLVFDkLGS-IEYLNKEAEDLFGVF 420
                 7899999999.*************54 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.2
       PAS_8  28 qaalellGys...adlkgellg...qllpvlrplle 57 
                 qa +e+lG +     lk++++g   ++l+++rp+ +
  EFC36477.1 443 QAIYEFLG-PtenSTLKADKIGsdqNYLDDIRPYNQ 477
                 67789999.336766777777666699999998876 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.028
       PAS_8   5 alfesspdgiavvdlgdrivd.vNqaalellGys.adlkgellgq 47 
                 a+ e +  +++ +++ + i++  N+aa   +G++ +++ g  + +
  EFC36477.1 549 AVTEMITIPVITINDKG-IIQvFNKAASSTFGFEaKEVVGRNVKI 592
                 66677888999888777.9998**********8877766666643 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1089 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       785  (0.0437838); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.79u 0.32s 00:00:01.11 Elapsed: 00:00:00.50
# Mc/sec: 6489.60
//
Query:       EFC36478.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       703  (0.0392102); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 771.17
//
Query:       EFC36479.1  [L=740]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.8e-62  209.4   0.0    1.1e-61  208.5   0.0    1.5  1  Pkinase         Protein kinase domain
    5.2e-39  134.1   0.0    9.1e-39  133.3   0.0    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
    0.00011   21.2   4.8    0.00097   18.0   4.8    2.1  1  Pkinase_fungal  Fungal protein kinase
     0.0032   17.4   0.0     0.0056   16.6   0.0    1.3  1  APH             Phosphotransferase enzyme family
     0.0033   16.8   0.0      0.028   13.7   0.0    2.2  1  Kinase-like     Kinase-like
  ------ inclusion threshold ------
        4.7    7.6   7.5        2.1    8.7   3.7    2.3  2  FtsH_ext        FtsH Extracellular


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  208.5   0.0   3.8e-65   1.1e-61       4     264 .]     171     446 ..     169     446 .. 0.90

  Alignments for each domain:
  == domain 1  score: 208.5 bits;  conditional E-value: 3.8e-65
                 EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH........HHSS CS
     Pkinase   4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle........rkgs 94 
                 ++klG+Gs+++Vy+++++ t+++vA+K+i+k+  ++++ k + +Eiki++ l++++ +r++e++e++++ y+vle++ gg+l+dl++        ++g 
  EFC36479.1 171 DSKLGSGSYASVYEGMHSITKQQVAIKVIDKKILNSSNLKYFSSEIKIMRDLDSDYCIRMVEFLETHHNCYVVLEFCGGGDLNDLIKkrsplvfnNNGR 269
                 579*********************************999******************************************************998999 PP

                 --HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET.........TTE.......EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.....TTS CS
     Pkinase  95 lseeeakkiakqilegleylHskgiiHrDlKpeNiLide.........kge.......lKitDFGlakelessskltsfvgtseYlAPEvl.....ken 172
                 ++e+ +kk+++q+ eg+eyl +k+i+HrDlKp+N+L+++         + +       lKi+D+Glakel++++ +++++gt+ ++APE++     k+ 
  EFC36479.1 270 MKERFLKKLIYQLSEGVEYLNRKQIMHRDLKPANLLFSKpmeiidngdD-DydidfgtLKIADLGLAKELDTNKLAQTVCGTPMFMAPEIMhylagKQV 367
                 **************************************86777776651.15566777*********************************99998888 PP

                 CBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 173 eyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                  y+ k+D+Ws+Gvi+y l +g+ pf +++  +    +++      +++     ++   ++ s+e++dllk ll+ dp++R+ +++  +hpy+
  EFC36479.1 368 TYDIKADLWSIGVIIYLLCYGNLPFIANDMAQ----QYR------RVMSG---TSFPTRDTSPELIDLLKGLLTFDPNSRFDFDQFYNHPYI 446
                 99************************433333....333......34322...34456778*****************************97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.3   0.0     3e-42   9.1e-39       3     256 ..     170     441 ..     168     443 .. 0.91

  Alignments for each domain:
  == domain 1  score: 133.3 bits;  conditional E-value: 3e-42
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEE.STTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT.... CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtl.keeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk.... 95 
                  +++klG+G++++V+eg  +     ++++Va+K++ k+  ++++ + + +e+kim++l+ +  ++++ +   +++ ++v+e++ gGdL++ ++k+    
   EFC36479.1 170 IDSKLGSGSYASVYEGMHS----ITKQQVAIKVIdKKILNSSNLKYFSSEIKIMRDLDSDYCIRMVEFLETHHNCYVVLEFCGGGDLNDLIKKRsplv 263
                  5789************999....8999*******445567777999999*********************************************9*** PP

                  ..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE...............TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHH CS
  Pkinase_Tyr  96 ..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse...............nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEs 176
                    ++ +++ + l ++++q+++G+eyL++k+++Hrdl   N L s+                 + ki+D GLa+++  d +  +++ + +p  +mapE+
   EFC36479.1 264 fnNNGRMKERFLKKLIYQLSEGVEYLNRKQIMHRDLKPANLLFSKpmeiidngdddydidFGTLKIADLGLAKEL--DTNKLAQTVCGTP-MFMAPEI 358
                  999999999999*********************************************99889*************..5555556666666.59***** PP

                  HHHSE.....EEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 177 lkekk.....ftsksDvWsfGvllwEiftlgespypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselv 256
                  +++       +  k+D Ws Gv+++ ++ +g+ p+   + ++ ++++ +g+  ++ + +++el +l+k  ++ dp++R +f +  
   EFC36479.1 359 MHYLAgkqvtYDIKADLWSIGVIIYLLC-YGNLPFIANDMAQQYRRVMSGTSFPTRD-TSPELIDLLKGLLTFDPNSRFDFDQFY 441
                  *988777888***************655.6***********************9988.7889*******************9875 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   4.8   3.2e-07   0.00097     196     397 ..      51     371 ..      45     387 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 3.2e-07
  Pkinase_fungal 196 ergvegvarlvahedveekdddiaeiRkgldvtkaekfrskrkvvsssssqelsskaevklkksesskkvekrsvdssv...stskrsr...... 281
                        ++ + ++  + +++ k d++++  + ++v ++ ++rs+ ++  s ++ ++s + ++++++ +s++++   s++++v   +++k++r      
      EFC36479.1  51 ATTTTTIETIGVSTTITRKLDETNKSSRLVKVGEEDSIRSSSDINLSEFKVPSSASPSSSPRNVNSKSSPA--SSGTTVvvtPEQKKKRvatthr 143
                     56667777777788888888888777777888888777777776666666555444444444444444443..3333333444444444678888 PP

  Pkinase_fungal 282 ............................................................................................... 281
                                                                                                                    
      EFC36479.1 144 vqssgglvyqsdkkekakkvgdflifidsklgsgsyasvyegmhsitkqqvaikvidkkilnssnlkyfsseikimrdldsdycirmveflethh 238
                     88888888888888889999999999999999999999999999999999999999999999999999999999999999999999999999999 PP

  Pkinase_fungal 282 .................lenrvhrrlvispvGkpiekaespkellealrDaIkghrsLflkagiLHrDiSenNilit.........dskke.... 346
                                      ++    + lv+++ G+   k +  k+l+  l + ++    L   ++i+HrD    N+l+          d   +    
      EFC36479.1 239 ncyvvlefcgggdlndlIK--KRSPLVFNNNGRM--KERFLKKLIYQLSEGVE---YLN-RKQIMHRDLKPANLLFSkpmeiidngD---Ddydi 322
                     9999999999999655433..3345899999995..55556777777777665...566.899**************7777775442...14545 PP

  Pkinase_fungal 347 gerkglLiDLDlakelsddssesgarertGTleFmaievlkgee.HsyrhDL 397
                     +  +  ++DL lakel++   ++ a++  GT+ Fma e+++     ++  D+
      EFC36479.1 323 DFGTLKIADLGLAKELDT---NKLAQTVCGTPMFMAPEIMHYLAgKQVTYDI 371
                     7777889**********6...3445689*********999842224444444 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   1.9e-06    0.0056     160     200 ..     282     331 ..     220     334 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.9e-06
                 --S....SS-EEEE-SS-SGGGEEEC........TTEEEEE---TT-EEEE CS
         APH 160 lpg....elptvllHgDlhpgNllvd......pddgrvtGviDfedaglgp 200
                 l        +++++H+Dl+p Nll+       ++++   + iDf+++++++
  EFC36479.1 282 LSEgveyLNRKQIMHRDLKPANLLFSkpmeiiDNGDD-DYDIDFGTLKIAD 331
                 3335555789****************88888633333.3578888887775 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.0   9.5e-06     0.028     157     288 .]     286     434 ..     250     434 .. 0.57

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 9.5e-06
  Kinase-like 157 aanLqakglvhgkftvdnllldekgglmlgg.......ftaLvra..gtkvvl..seve......kgfaPpEllgsrggytrknktkmthkldaWqlG 237
                  + +L  k+++h ++++ nll+ +   ++  g       f+ L  a  g    l  ++ +        f  pE+    + y   +++++ +k d W +G
   EFC36479.1 286 VEYLNRKQIMHRDLKPANLLFSKPMEIIDNGdddydidFGTLKIAdlGLAKELdtNKLAqtvcgtPMFMAPEI----MHYLAGKQVTYDIKADLWSIG 379
                  6677777777777777777766544443221111111133332221111111111222211012222333443....4477779************** PP

  Kinase-like 238 lviyriwclklPltlateeakeew.......kfklckkipekvkaLlkkfLqlsqedR 288
                  + iy +   +lP+  +++++ +++       +f + +  + ++  Llk++L ++ + R
   EFC36479.1 380 VIIYLLCYGNLPF--IANDMAQQYrrvmsgtSF-PTRDTSPELIDLLKGLLTFDPNSR 434
                  *******9****9..445555555555666344.455555555567888888887766 PP

>> FtsH_ext  FtsH Extracellular
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   3.7   0.00071       2.1      41     100 ..      16      77 ..      13      85 .. 0.88
   2 ?   -1.7   0.1       1.3   3.8e+03      65      75 ..     506     516 ..     461     533 .. 0.58

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00071
    FtsH_ext  41 qgnvekvvvqestis..alirrptgdgvsttkkgnstttystptlgsvesleekLeealksk 100
                 ++n ++vvv++++ +  ++ ++++++++s  ++ ++ttt+++ t+g  + +++kL+e +ks 
  EFC36479.1  16 NNNDDSVVVDDDNNNgsSGSSDGNNSFDSAATTATATTTTTIETIGVSTTITRKLDETNKSS 77 
                 55667899997777777999**************************************9986 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.3
    FtsH_ext  65 gvsttkkgnst 75 
                     +++++st
  EFC36479.1 506 PIVASSSSTST 516
                 22222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (740 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       889  (0.0495845); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.81u 0.37s 00:00:01.18 Elapsed: 00:00:00.58
# Mc/sec: 3863.57
//
Query:       EFC36480.1  [L=145]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (145 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       343  (0.019131); expected 358.6 (0.02)
Passed bias filter:                      266  (0.0148363); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 818.33
//
Query:       EFC36481.1  [L=132]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       565  (0.0315132); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.27s 00:00:00.70 Elapsed: 00:00:00.43
# Mc/sec: 927.62
//
Query:       EFC36482.1  [L=324]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      5e-05   23.0   0.0    7.3e-05   22.5   0.0    1.2  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0   4.1e-09   7.3e-05      23     156 ..      72     219 ..      54     234 .. 0.83

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 4.1e-09
  Guanylate_cyc  23 ssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevavesk...........eglkvrvGih 107
                    s + +p ++v+lL +l++++d++++ + +  v++  d   ++ +++ ++++h +k++  a  + e+l++v++++            e ++ r  i 
     EFC36482.1  72 SLEGNPTHLVSLLGDLFSQVDTVIRTTSGHLVNFENDILTIAYNTTINQNNHEEKAVASAQLLQEKLTNVKENKWresgllreeicELINFRFAIC 167
                    445569****************************************9999999999998877888889999888346799999999********** PP

  Guanylate_cyc 108 tGpvvagviG.akkprydvwGntvnlAsrmestgkagkiqv..seetyellk 156
                      ++++g iG +  +++++++ t     ++   gk+ k+ +  +++ +++ +
     EFC36482.1 168 AQKTFCGNIGtKDIKHFTIFSSTRHNLDQIIRFGKKLKVPIiiTQHIKQYCH 219
                    **********555689******998888888888888887766777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (324 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       783  (0.0436723); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2214.54
//
Query:       EFC36483.1  [L=1602]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.1e-58  196.9   0.1    5.1e-58  195.7   0.1    1.7  1  Guanylate_cyc    Adenylate and Guanylate cyclase catalytic do
    2.4e-15   56.6   0.1    1.4e-14   54.1   0.1    2.5  1  PAS_9            PAS domain
    2.8e-05   24.3   2.6      0.043   14.1   0.1    3.4  3  DUF3267          Putative zincin peptidase
     0.0001   22.3   0.0    0.00032   20.7   0.0    1.9  1  PAS              PAS fold
     0.0022   18.0   0.0     0.0089   16.0   0.0    2.0  1  PAS_8            PAS domain
     0.0039   16.3   9.7      0.098   11.7   1.3    3.3  3  PHA_synth_III_E  Poly(R)-hydroxyalkanoic acid synthase subuni
      0.009   16.0   4.2       0.97    9.3   0.0    3.1  3  DUF4711          Domain of unknown function (DUF4711)
  ------ inclusion threshold ------
      0.018   15.3   0.0      0.054   13.7   0.0    1.8  1  PAS_4            PAS fold
      0.022   14.2   0.1      0.022   14.2   0.1    3.2  4  HNOBA            Heme NO binding associated
      0.035   14.1  10.3        7.4    6.5   0.3    4.2  4  Armet            Degradation arginine-rich protein for mis-fo
       0.14   11.9   1.1         14    5.4   0.1    2.5  2  Sigma70_r4_2     Sigma-70, region 4
       0.23   11.6   3.5        1.3    9.1   0.4    3.0  2  GIT1_C           G protein-coupled receptor kinase-interactin
       0.68   10.4   5.9          9    6.8   0.2    3.5  2  Cep57_MT_bd      Centrosome microtubule-binding domain of Cep
        2.1    8.0  10.7        2.9    7.5   2.7    4.1  3  Baculo_11_kDa    Baculovirus 11 kDa family
        8.7    7.1  15.6         33    5.2   0.1    5.1  4  PMC2NT           PMC2NT (NUC016) domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  195.7   0.1   4.2e-61   5.1e-58       3     182 ..    1351    1531 ..    1349    1532 .. 0.98

  Alignments for each domain:
  == domain 1  score: 195.7 bits;  conditional E-value: 4.2e-61
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevave 95  
                     ae++ +vti+F+d+vgft++ss +++ ++v +Ln+++++fd+l++++ + k+ktiGday +vsg++ +++ +h ++++++a+ + + l+ ++++
     EFC36483.1 1351 AEKFPDVTIFFSDMVGFTKMSSGMEADQLVMMLNTIVNEFDKLTEKYLIDKIKTIGDAYFAVSGTHsSKSSDHPERMLKFAISVYSFLRDFNIK 1444
                     578999************************************************************788999********************** PP

  Guanylate_cyc   96 skeglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182 
                       +++++r+G+htGp+v gviG+kk+ yd+wG+t+n+Asrmestg++g+iq+s++tye   + ++e++er++++vkGkg+++ty+l+
     EFC36483.1 1445 FGKEVNLRIGMHTGPCVGGVIGTKKFAYDLWGDTINTASRMESTGVPGRIQISRATYERVFDLGYEFEERESIYVKGKGEMKTYLLK 1531
                     ************************************************************************************997 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.1   0.1   1.2e-17   1.4e-14       2     104 .]    1207    1312 ..    1206    1312 .. 0.97

  Alignments for each domain:
  == domain 1  score: 54.1 bits;  conditional E-value: 1.2e-17
       PAS_9    2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.......kerevevvlirkngetfwvlltaspvkdddge 91  
                  dg +i+np+g+++ +N++ ++++Gy++ee+lg ++++lf   + + e++  ++++++        ++ ++ev+  rkn +tf++ +++s  +  ++ 
  EFC36483.1 1207 DGSIICNPKGEVVMFNPSSEDMFGYKKEEILGIRLETLF--TELNVEKITVLIDSMKVcneetgvSADSFEVTGLRKNKTTFPAFVSISISQYLGKP 1301
                  7999***********************************..******************************************99999999999*** PP

       PAS_9   92 lvgiivilrDite 104 
                  + +  ++++D+t+
  EFC36483.1 1302 ILS--CFVKDVTQ 1312
                  ***..******97 PP

>> DUF3267  Putative zincin peptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0024       2.8      32      73 ..     351     391 ..     326     405 .. 0.76
   2 !   14.1   0.1   3.6e-05     0.043      35      74 ..     605     643 ..     588     656 .. 0.83
   3 ?   -3.0   0.1       7.6     9e+03      46      69 ..     890     913 ..     884     937 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0024
     DUF3267  32 klliayatsseallskkqfiiillaPfvllgilllllalllp 73 
                 k+ ++y  s +++ + +++  ++++Pfv++++l+ll++l + 
  EFC36483.1 351 KQEAFYRNSINTP-EHRKSYYFTFLPFVIVSFLVLLILLTMS 391
                 4667888888888.8888888999*************99865 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 3.6e-05
     DUF3267  35 iayatsseallskkqfiiillaPfvllgilllllalllps 74 
                 ++y  s + + +++++ ++l++Pf++++il++l +l+l  
  EFC36483.1 605 AFYRNSINMP-ERRKSFFMLFLPFIVISILIILFMLILSL 643
                 5666666777.99**********************99865 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 7.6
     DUF3267  46 skkqfiiillaPfvllgillllla 69 
                 +k+++ii++   f+++ ++ ++ +
  EFC36483.1 890 PKNKIIIYTAITFFVVALVSPIQI 913
                 677788888888888777666554 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0   2.6e-07   0.00032       3      69 ..    1198    1260 ..    1196    1278 .. 0.86

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 2.6e-07
                  HHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHT CS
         PAS    3 lraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqg 69  
                   r+il+s  d+ ++ + +g+++ +N++ e+++G++ ee+lg  l  l+ e      +e+++ l+ ++
  EFC36483.1 1198 TRSILNSGVDGSIICNPKGEVVMFNPSSEDMFGYKKEEILGIRLETLFTEL----NVEKITVLIDSM 1260
                  689999************************************999999886....666666555554 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   7.4e-06    0.0089       4      53 ..    1199    1249 ..    1197    1260 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 7.4e-06
       PAS_8    4 ralfesspdgiavvd.lgdrivdvNqaalellGys.adlkgellgqllpvlr 53  
                  r++++s  dg ++++  g+ +v+ N++ ++++Gy+ ++++g  l +l+++l+
  EFC36483.1 1199 RSILNSGVDGSIICNpKGE-VVMFNPSSEDMFGYKkEEILGIRLETLFTELN 1249
                  7888988897777998888.***************88888877767777666 PP

>> PHA_synth_III_E  Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.2    0.0009       1.1      43     116 ..     187     261 ..     162     302 .. 0.85
   2 !   11.7   1.3   8.2e-05     0.098      49     123 ..     446     521 ..     435     557 .. 0.82
   3 ?    0.4   1.1      0.24   2.8e+02      55     146 ..     518     604 ..     508     618 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0009
  PHA_synth_III_E  43 keasdaakelmermveqqkayfrlleqfakafadkdasasavedaweqlekaieqlqkafqgli.sdladklyle 116
                      +++s ++k+l+er+ ++q + + l ++f+k++++++ s+++ e+ +++ ++ i   ++a+++ +  ++++k++l 
       EFC36483.1 187 ANVSYEVKKLLERLDKKQSQILALHQEFFKELSSENPSEDKLEKINRKSNNLIIFCENAYKNCMyTNMNNKTLLR 261
                      4588899*****************************************999999999999886514444466655 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 8.2e-05
  PHA_synth_III_E  49 akelmermveqqkayfrlleqfakafadkdasasavedaweqlekaieqlqkafqglisdlad.klyleelqkfla 123
                       ++++e++ + q + ++l + f+k++++++ s+++ ed ++q+++ +   ++a+++++s++ + k+++ +   fl 
       EFC36483.1 446 LQKILEKLEKRQAKIINLHQDFFKELSSENPSETKLEDINRQAHNLTHYCENAYKNSMSSNMNnKTLMRAYAHFLE 521
                      57899*************************************************9987776664776666555554 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.24
  PHA_synth_III_E  55 rmveqqkayfrlleqfakafadkdasasavedaweqlekaieqlqkafqglisdladklyleelqkflafWelpldtwqraasslselmpgd 146
                      +++e  k  ++++ +++++ ++ + +++a +   +q e+ +  +++++++l+++ +      +++++++f e  +d+w +  + + e+m  +
       EFC36483.1 518 HFLETFKFELEMAAELYEEANQIE-EEKAKSTKKKQPENRVLPYATSTSQLMKHSKS---NAAMKNAVSFDEV-VDNWDSISARMEETMREE 604
                      333333333444444444332221.22222222233345555566666666666554...5677777777777.999999999999988654 PP

>> DUF4711  Domain of unknown function (DUF4711)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.3       3.7   4.4e+03     121     189 ..     254     322 ..     245     327 .. 0.57
   2 !    6.8   0.2    0.0047       5.7       4      52 ..     387     436 ..     384     465 .. 0.86
   3 !    9.3   0.0   0.00082      0.97       4      45 ..     638     679 ..     636     704 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 3.7
     DUF4711 121 fqtgslltgkvfLpgisqckvypvkeassetlsttttsitpkekeeekttstddfssedtDedlkkrqk 189
                 +++++ll+  ++   i++ ++  + e   e+ +++     ++++++ k   +  ++s + +++l kr+k
  EFC36483.1 254 MNNKTLLRAYAYFLEIFRFEIEVANELYEEANQIEEEKSKTNKQSHSKSNRVVPYTSASEESSLMKRRK 322
                 566777888888888888888775444444444333333333333445555555555555566666655 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0047
     DUF4711   4 iLvfSliivsydvnkkelrdsscqveqlpelfpkdvrsirvllvq.eaqa 52 
                 +L +Sl++ s  +++  l++  c++  +p+++++++rsi+    + e+q 
  EFC36483.1 387 LLTMSLVFSSEFTSRTVLEEKICSIAGAPSIMANHIRSIQARSKEiEVQS 436
                 6889***********************************98765544444 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00082
     DUF4711   4 iLvfSliivsydvnkkelrdsscqveqlpelfpkdvrsirvl 45 
                 +L++Sli+ s  +++  l++  c++  +p++++++vr+++  
  EFC36483.1 638 MLILSLIVSSEFTSRTALEEKICSIAGAPSIMANHVRTLQAR 679
                 69***********************************98764 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   4.6e-05     0.054       2      48 ..    1203    1249 ..    1202    1260 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 4.6e-05
       PAS_4    2 dslpdalavldpdgrvlyaNaaaaelfgappeellGktlaellpeed 48  
                  +s  d+ ++++p g v+  N++++++fg+  ee+lG +l+ l++e  
  EFC36483.1 1203 NSGVDGSIICNPKGEVVMFNPSSEDMFGYKKEEILGIRLETLFTELN 1249
                  67789999******************************999988765 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.4       2.4   2.9e+03     189     207 ..     278     296 ..     269     328 .. 0.65
   2 ?   -1.6   0.3       1.2   1.5e+03     172     207 ..     427     462 ..     422     468 .. 0.85
   3 ?   -4.0   2.2         7   8.3e+03     184     184 ..     526     526 ..     442     577 .. 0.65
   4 ?   14.2   0.1   1.8e-05     0.022     188     221 .]    1310    1343 ..    1304    1343 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.4
       HNOBA 189 aeLeesmkeleeekkrtde 207
                 +eL e+ +++eeek +t++
  EFC36483.1 278 NELYEEANQIEEEKSKTNK 296
                 4555555555555555543 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.2
       HNOBA 172 qqsaelelaldqleeksaeLeesmkeleeekkrtde 207
                  +s+e+e++ +  ++ s eL++ +++le+ + ++ +
  EFC36483.1 427 ARSKEIEVQSQDGDALSFELQKILEKLEKRQAKIIN 462
                 5788999999999999************99998765 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 7
       HNOBA 184 l 184
                 +
  EFC36483.1 526 E 526
                 1 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 1.8e-05
       HNOBA  188 saeLeesmkeleeekkrtdeLLysmiPkevAerL 221 
                   ++L++    l eekk+++eLL +++P  vA+rL
  EFC36483.1 1310 VTQLKKHSLLLGEEKKKSEELLLNILPLPVANRL 1343
                  67999***************************98 PP

>> Armet  Degradation arginine-rich protein for mis-folding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.3    0.0089        11      51     102 ..     167     222 ..     160     251 .. 0.73
   2 ?    5.5   0.1     0.012        15      11      57 ..     271     317 ..     264     346 .. 0.85
   3 ?    6.5   0.3    0.0062       7.4      69     125 ..     442     498 ..     394     518 .. 0.82
   4 ?   -1.6   0.1         2   2.3e+03       8      52 ..     519     564 ..     512     583 .. 0.66

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0089
       Armet  51 aledaatkilsevskp....lsvsvPvekiCeklkkkdsqicelkyekkidlksvd 102
                 a+e++   i++e+        +vs  v+k+ e+l kk+sqi  l+ e   +l+s +
  EFC36483.1 167 ASEESSGAICKEIEANsenyANVSYEVKKLLERLDKKQSQILALHQEFFKELSSEN 222
                 667777777777654311115678899***************99877555555544 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.012
       Armet  11 rllkslkekekesekkiekelkkvCkeakgkenrlCyylgaledaat 57 
                 r+  ++ ++  e+ ++ie+e +k+ k++++k nr+  y  a+e++  
  EFC36483.1 271 RFEIEVANELYEEANQIEEEKSKTNKQSHSKSNRVVPYTSASEESSL 317
                 6777788889999****************************999864 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0062
       Armet  69 vsvPvekiCeklkkkdsqicelkyekkidlksvdlkklkvkeLkkiledWgeeCkgC 125
                 +s   +ki ekl+k++++i +l+ +   +l+s + +  k +++ +  ++    C+  
  EFC36483.1 442 LSFELQKILEKLEKRQAKIINLHQDFFKELSSENPSETKLEDINRQAHNLTHYCENA 498
                 345679*******************999**************999999998888865 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 2
       Armet   8 flerllkslk..ekekesekkiekelkkvCkeakgkenrlCyylgal 52 
                 fle +  +l+  ++  e+ ++ie+e +k  k+ k+ enr+  y  ++
  EFC36483.1 519 FLETFKFELEmaAELYEEANQIEEEKAKSTKK-KQPENRVLPYATST 564
                 66655555541155667889999998777665.55666665554444 PP

>> Sigma70_r4_2  Sigma-70, region 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1      0.02        24       4      24 ..     193     213 ..     190     214 .. 0.89
   2 ?    5.4   0.1     0.012        14       3      23 ..     445     465 ..     443     467 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.02
                   HHHHHTTS-HHHHHHHHHHHT CS
  Sigma70_r4_2   4 lrealaeLperqreifllryl 24 
                   + ++l++L ++q++i+ l+++
    EFC36483.1 193 VKKLLERLDKKQSQILALHQE 213
                   6789**************986 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.012
                   HHHHHHTTS-HHHHHHHHHHH CS
  Sigma70_r4_2   3 alrealaeLperqreifllry 23 
                   +l++ l++L +rq +i+ l++
    EFC36483.1 445 ELQKILEKLEKRQAKIINLHQ 465
                   799***************985 PP

>> GIT1_C  G protein-coupled receptor kinase-interacting protein 1 C term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.2      0.24   2.9e+02      52      85 ..     215     248 ..     188     266 .. 0.72
   2 ?    9.1   0.4    0.0011       1.3      51      94 ..     467     510 ..     440     518 .. 0.69

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.24
      GIT1_C  52 fpenlseetlrtaLkqLtssaerLqeeCeelqea 85 
                 f e +se++ + +L++++++++ L   Ce++ ++
  EFC36483.1 215 FKELSSENPSEDKLEKINRKSNNLIIFCENAYKN 248
                 3444455555668****************99883 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0011
      GIT1_C  51 lfpenlseetlrtaLkqLtssaerLqeeCeelqeaeseskedik 94 
                  f e +se++ +t+L++++++a+ L++ Ce++ +++ +s+ + k
  EFC36483.1 467 FFKELSSENPSETKLEDINRQAHNLTHYCENAYKNSMSSNMNNK 510
                 34455566667779******************994444443333 PP

>> Cep57_MT_bd  Centrosome microtubule-binding domain of Cep57
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.2    0.0076         9      55      75 ..     191     211 ..     181     212 .. 0.89
   2 ?    3.7   1.3     0.073        87      45      75 ..     434     464 ..     418     465 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0076
  Cep57_MT_bd  55 eeleelvkrlEaKadqIykLy 75 
                   e+++l++rl++K+ qI +L+
   EFC36483.1 191 YEVKKLLERLDKKQSQILALH 211
                  589**************9998 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.073
  Cep57_MT_bd  45 lgkrkRkdLaeeleelvkrlEaKadqIykLy 75 
                  ++++  ++L  el++++++lE+++ +I +L+
   EFC36483.1 434 VQSQDGDALSFELQKILEKLEKRQAKIINLH 464
                  5889999********************9987 PP

>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0       0.2   2.4e+02      27      67 ..     131     171 ..     125     188 .. 0.82
   2 ?   -0.1   0.7      0.58   6.9e+02      43      59 ..     376     392 ..     367     407 .. 0.54
   3 ?    7.5   2.7    0.0025       2.9      36      68 ..     621     653 ..     615     660 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.2
  Baculo_11_kDa  27 srNrsflrdFvLvicglvvfvvivlfilLlvvilknaeaee 67 
                    +rN sf+++    ++ +++ + ++ + l+ ++i+++a+ e+
     EFC36483.1 131 KRNESFIKSKYQAVAWIMLHIYMIYYSLITCSITTTASEES 171
                    79*******999************99999999999876654 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.58
  Baculo_11_kDa  43 lvvfvvivlfilLlvvi 59 
                    +v++  +vl+ilL +++
     EFC36483.1 376 FVIVSFLVLLILLTMSL 392
                    33333333444443333 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0025
  Baculo_11_kDa  36 FvLvicglvvfvvivlfilLlvvilknaeaeea 68 
                    F+L +  +v+ ++i+lf+l+l  i++++ ++++
     EFC36483.1 621 FMLFLPFIVISILIILFMLILSLIVSSEFTSRT 653
                    788888888899999999999999887665554 PP

>> PMC2NT  PMC2NT (NUC016) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.3      0.19   2.3e+02      23      63 ..     194     229 ..     177     244 .. 0.80
   2 ?    2.8   0.7      0.16   1.9e+02      31      79 ..     293     342 ..     275     351 .. 0.52
   3 ?    3.3   0.3      0.11   1.4e+02      23      73 ..     447     492 ..     429     502 .. 0.81
   4 ?    5.2   0.1     0.028        33      38      78 ..     562     599 ..     543     603 .. 0.71

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.19
      PMC2NT  23 pefaksldeqserllslinsllklaaskseisasskleded 63 
                 +++ ++ld++++++l+l +++ k ++s++  +++     ++
  EFC36483.1 194 KKLLERLDKKQSQILALHQEFFKELSSENPSEDK-----LE 229
                 566789******************9999988553.....33 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.16
      PMC2NT  31 eqserllslinsllklaaskseisassklededdvee..kfksvvdvvDsl 79 
                 +++++  s  n+++ ++++++e s   k++++d +++  +f++vvd  Ds+
  EFC36483.1 293 KTNKQSHSKSNRVVPYTSASEESSLM-KRRKSDTLKHgvSFDEVVDNWDSI 342
                 34444444444444444444444443.555555555555566666555554 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.11
      PMC2NT  23 pefaksldeqserllslinsllklaaskseisassklededdveekfksvv 73 
                 +++ ++l++ ++++++l +++ k ++s++  ++     +++d++++ ++++
  EFC36483.1 447 QKILEKLEKRQAKIINLHQDFFKELSSENPSET-----KLEDINRQAHNLT 492
                 5677899********************999844.....5777776776665 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.028
      PMC2NT  38 slinsllklaaskseisassklededdveekfksvvdvvDs 78 
                 +++++l+k+ +s+      ++  + d+v+++++s++  +++
  EFC36483.1 562 TSTSQLMKHSKSNAAM---KNAVSFDEVVDNWDSISARMEE 599
                 3456666666666666...567999*********9977765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1602 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2029  (0.113169); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 1.22u 0.36s 00:00:01.58 Elapsed: 00:00:00.57
# Mc/sec: 8436.95
//
Query:       EFC36484.1  [L=176]
Description: hypothetical protein NAEGRDRAFT_82221 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.037   13.5   0.3      0.054   12.9   0.3    1.3  1  DUF599    Protein of unknown function, DUF599


Domain annotation for each model (and alignments):
>> DUF599  Protein of unknown function, DUF599
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.3     3e-06     0.054     114     145 ..      12      47 ..       4      79 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3e-06
      DUF599 114 llliflvAFlkfvqsirlynhasfligavPe.....d 145
                  +lifl++F++f+ + r++ +++  +   P+     +
  EFC36484.1  12 SILIFLCSFVSFTTAQRFVLQVNTTV-DHPMfytgyS 47 
                 579*********************99.5576444331 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.35s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 992.66
//
Query:       EFC36485.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1451  (0.0809303); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 2572.77
//
Query:       EFC36486.1  [L=538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.1    9.7   3.0         16    5.9   0.0    2.6  2  Wzz       Chain length determinant protein


Domain annotation for each model (and alignments):
>> Wzz  Chain length determinant protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0   0.00086        16      12      55 ..       3      47 ..       1      85 [. 0.69
   2 ?    2.7   1.2     0.009   1.6e+02      37      78 ..     490     531 ..     489     531 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.00086
                XXXXXXXXXXXXXXXXXXXXXXXXXX.XX-EEEEEEEES--CHHH CS
         Wzz 12 LwkrkklIilvtllfallaviyafla.tpkYtataqilvpekkqv 55
                + ++ + ++l+++l++++    af+a +++Y+ + q+l ++    
  EFC36486.1  3 VVRGVLALLLTVALVLCFTTQSAFAAkQQRYKQELQVLADQLMMT 47
                678888999999999***999996661568********9997543 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.009
                 XXX-EEEEEEEES--CHHHHH.HHHHCCHHHHHHHHHHHHHHH CS
         Wzz  37 atpkYtataqilvpekkqvea.ssltaqdvqanlqlasteiei 78 
                 at+++ a  qi+   +++ ++ ++  +++ q++ q+++t  ei
  EFC36486.1 490 ATQVWDAVQQIAGAMNNG-QQpTDAAVEQPQPDQQPTETTPEI 531
                 799*************99.566778888*******99998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       948  (0.0528752); expected 358.6 (0.02)
Passed bias filter:                      715  (0.0398795); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 3375.77
//
Query:       EFC36487.1  [L=682]
Description: Hypothetical protein NAEGRDRAFT_54386 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-06   27.4   0.7      2e-06   27.4   0.7    6.8  8  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.12   2.2e+03      16      32 ..      59      75 ..      52      90 .. 0.74
   2 ?   -4.0   0.0      0.71   1.3e+04      28      37 ..     167     176 ..     162     179 .. 0.69
   3 ?    1.9   0.0      0.01   1.8e+02      21      39 ..     253     272 ..     239     287 .. 0.58
   4 ?    0.2   0.4     0.036   6.5e+02      22      36 ..     317     335 ..     301     353 .. 0.68
   5 ?    0.5   0.5     0.029   5.2e+02      25      47 ..     401     425 ..     364     428 .. 0.76
   6 !   27.4   0.7   1.1e-10     2e-06       1      49 []     454     508 ..     454     513 .. 0.94
   7 ?   -3.5   0.0      0.51   9.2e+03      32      45 ..     539     552 ..     537     554 .. 0.69
   8 !    2.2   0.0    0.0085   1.5e+02      26      41 ..     620     636 ..     603     642 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.12
     DUF4116 16 lkylseeLknDkeivlk 32
                +  ls+e+k++  + + 
  EFC36487.1 59 YLDLSDEIKRNTTFNKN 75
                56799999998766555 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 0.71
     DUF4116  28 eivlkAvkqn 37 
                 ei  kA+++n
  EFC36487.1 167 EIRSKAIRSN 176
                 6667788877 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.01
     DUF4116  21 eeLknDkeivlkAvk.qngt 39 
                 e+++nD+ +v++ +k +ng+
  EFC36487.1 253 ESISNDFLVVKELLKtSNGS 272
                 55666666666666633332 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.036
     DUF4116  22 eLknDkeivlkAvk....q 36 
                 +L  D++++ k +     q
  EFC36487.1 317 KLLEDRNLIEKLISdqkyQ 335
                 6888999999988754443 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.029
     DUF4116  25 nDkeivlkAvk..qngtalsyasee 47 
                 n k+++l ++k  +++t+ls +s+e
  EFC36487.1 401 NEKQVLLLILKhrNSKTILSNISDE 425
                 5677788888864455788888876 PP

  == domain 6  score: 27.4 bits;  conditional E-value: 1.1e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk......qngtalsyaseeLr 49 
                 + E++l++++ n++++  +s++Lk+D  +v k ++      +++t+l+ ++ +Lr
  EFC36487.1 454 NSELCLKVCTFNPLWFSLISDKLKSDAMFVQKLCNvlinrkSYPTFLNEIDQKLR 508
                 67********************************999888889999999998887 PP

  == domain 7  score: -3.5 bits;  conditional E-value: 0.51
     DUF4116  32 kAvkqngtalsyas 45 
                 +++k n + l+++s
  EFC36487.1 539 AICKENIKLLRFMS 552
                 56777777888877 PP

  == domain 8  score: 2.2 bits;  conditional E-value: 0.0085
     DUF4116  26 DkeivlkAvkq.ngtal 41 
                 D eiv+ Av + ng++l
  EFC36487.1 620 DDEIVKLAVSKlNGNVL 636
                 88999999884488776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (682 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       664  (0.037035); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.45
# Mc/sec: 4558.18
//
Query:       EFC36488.1  [L=656]
Description: hypothetical protein NAEGRDRAFT_56405 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   9.1e-262  869.6  10.3     1e-261  869.4  10.3    1.0  1  HSP70           Hsp70 protein
    4.5e-18   65.1   0.3    1.7e-16   60.0   0.1    2.3  2  MreB_Mbl        MreB/Mbl protein
    0.00082   18.7   0.2       0.02   14.2   0.1    2.4  2  Hydantoinase_A  Hydantoinase/oxoprolinase
     0.0082   15.2   0.1       0.39    9.6   0.1    2.3  2  DDR             Diol dehydratase reactivase ATPase-like domai
  ------ inclusion threshold ------
      0.064   13.6   1.0       0.55   10.6   0.3    2.4  2  kleA_kleC       Uncharacterized KorC regulated protein A
       0.16   12.4   6.1         21    5.6   0.2    3.6  3  FtsA            Cell division protein FtsA
        2.7    7.2   5.8        5.3    6.3   5.8    1.4  1  DUF4407         Domain of unknown function (DUF4407)


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  869.4  10.3    4e-265    1e-261       1     599 []       8     609 ..       8     609 .. 0.98

  Alignments for each domain:
  == domain 1  score: 869.4 bits;  conditional E-value: 4e-265
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXTTSEEETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHHHTTXSSEEEEETTSBEEE CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrttPsvvaFtkkerlvGeaAkrqavtnpkntvfsvKrliGrkfsdpevqkeikelpykvvkkengkavv 99 
                 +iGiDLGtt+s+v+v  g+++e++ n++gnrttPs+vaFt++erl+G+aAk+q+++np+ntvf++KrliGrkf+d++vq+++k++p+kv +k ++k+++
  EFC36488.1   8 AIGIDLGTTYSCVGVYMGDNVEIVPNDQGNRTTPSYVAFTDEERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFTDSSVQSDMKHWPFKVITKGDDKPYI 106
                 59************************************************************************************************* PP

                 EEEETTE..EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSSSCEEEEEEEEXSS CS
       HSP70 100 eveaage..kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkdkernvlvyDlGgg 196
                 +ve+++e  +ftpeq+s+mvL+k++++ae+ylgk+v++av+tvPaYfnd+qRqatkdAg+iAGL+vlRi+NepTAaa+aYGl+kk  ernvl++DlGgg
  EFC36488.1 107 QVEYKNEthTFTPEQVSSMVLTKMRDIAEQYLGKQVKKAVVTVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKG-ERNVLIFDLGGG 204
                 *****9999****************************************************************************9.************ PP

                 XEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTEEEEEEEEH CS
       HSP70 197 tfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrlkeaaekaKkeLSsskqteinleietvdedgkdlseklsR 295
                 tfdvSil++e+GvfevkaTagDthlGGedfD+++v+++++efk+k++ dl+++++al+rl++ +e+aK++LSs  +++++++++++++ g dl+++++R
  EFC36488.1 205 TFDVSILNIEDGVFEVKATAGDTHLGGEDFDNRMVDFCCQEFKRKHKKDLQENPRALRRLRTSCERAKRNLSS--AANASINVDSIMD-GIDLDITMTR 300
                 *************************************************************************..899999******9.********** PP

                 HHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTT.CHHBSSSHTTTHHHHHHHHHHHHHCTCGCSHCCEEEEBESS- CS
       HSP70 296 akfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfg.kepsktvnpDeavaiGAAvqagvlsgeeevkdllllDvtpLs 393
                 akfe++++d+++++ epv+k+l+d++l+k++id+vvlvGGstRiPkvqe++ke+f+ ke++k++npDeava+GAAvqagvl+g  + + +ll DvtpLs
  EFC36488.1 301 AKFEQMNMDMFRNCFEPVKKVLQDSGLDKSQIDDVVLVGGSTRIPKVQEMLKEFFNgKELCKSINPDEAVAYGAAVQAGVLTG--KETRVLLIDVTPLS 397
                 *******************************************************99**************************..9999********** PP

                 EEEEETTTEEEEEESTTCBSSEEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEEEEETTTCCEE CS
       HSP70 394 lgietlggvmtkliernttiptkksqvfstaadnqtaveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvsakdketgkee 492
                 lgiet+ggvmtkliernttip kksq+f+t+adnqtav+i+v++ger+++kdn+llg+f+l+gippaprGvp+ieVtf+idanGi++v+akd+++gk+e
  EFC36488.1 398 LGIETAGGVMTKLIERNTTIPCKKSQIFTTYADNQTAVTIQVYEGERTMTKDNHLLGKFNLEGIPPAPRGVPKIEVTFEIDANGIMKVAAKDESSGKTE 496
                 *************************************************************************************************** PP

                 EEEEECCSS.SBHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..GGGSTHHHH....HHHHHHHHHHHCHTTSSCHHHHHHHHH CS
       HSP70 493 eitieaseg.lseeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleee..aekvseaek....ekvesaieeLkeeleeeekeeieakte 584
                 +iti++++g ls+eei++m ++ae+++++d + ++++eakn++e+++y++++++e+   a k++e++k    e+ e+ai++++++ ++++kee+eak++
  EFC36488.1 497 NITITNDKGrLSKEEIDEMLRQAENMKAQDDELRKKVEAKNHLESYAYQMKSTVEDPnlAGKIPESDKktikEACEAAINWIDNN-QTASKEEFEAKQK 594
                 *********9**********************************************98999999999966766777788888888.6888********* PP

                 HHHHHHHHHHHHHHH CS
       HSP70 585 elkkvvekiaeklye 599
                 el+  + +i++kly+
  EFC36488.1 595 ELEGKCAPIISKLYQ 609
                 **********99986 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.016        42       3      50 ..       8      61 ..       6      75 .. 0.64
   2 !   60.0   0.1   6.5e-20   1.7e-16      77     316 ..     125     375 ..     118     383 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.016
                EEEEEE-SSEEEE..EETTTEEEE.EE......ES-EEEETTT--EEEESHHHHTTT CS
    MreB_Mbl  3 dlgiDLGtantlv..yvkgkgivl.ne......psvvAikkktkkvlavGeeAkkml 50
                 +giDLGt+   v  y+ ++  ++ n+      ps vA++ +++    +G+ Ak+ +
  EFC36488.1  8 AIGIDLGTTYSCVgvYMGDNVEIVpNDqgnrttPSYVAFTDEER---LIGDAAKNQV 61
                69******998865588887655423222223377777765554...3466666655 PP

  == domain 2  score: 60.0 bits;  conditional E-value: 6.5e-20
                 HHHHHHHHHHTSS-S.S--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-EEEEEEETTEEE.....E CS
    MreB_Mbl  77 llkyfikkvkkkksl.skprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglpveepsgnmvvdiGggttevavislggiv.....t 169
                 ++ + +++++++    + ++ v++vP   ++ +r+A k+a   aG +   +i+ep aAAi  gl+ +  +  ++ d+Gggt +v+++ + + v     t
  EFC36488.1 125 MVLTKMRDIAEQYLGkQVKKAVVTVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKGERNVLIFDLGGGTFDVSILNIEDGVfevkaT 223
                 444555555554333256789*******************************************************************99876222222 PP

                 EEEES-SHHHHHHHHHHHH....HHHHSEE--H..HHHHHHHHHH-BSS--HHHH.EEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHH CS
    MreB_Mbl 170 sksvrvaGdeldeaiikyi....rkkynlliGe..rtaekikieigsavkeeeee.kmeikGrdlvtglpkevevsseevrealkepvsaiveavkevL 261
                 +   +++G+++d+ ++++     ++k++  + e  r  ++++++   a+ + ++  + +i+   ++ g+   ++++ ++ +++  +++++  e vk+vL
  EFC36488.1 224 AGDTHLGGEDFDNRMVDFCcqefKRKHKKDLQEnpRALRRLRTSCERAKRNLSSAaNASINVDSIMDGIDLDITMTRAKFEQMNMDMFRNCFEPVKKVL 322
                 345789**********9963333666666665511455666666666666555547999**************************************** PP

                 HTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS-.EEE-SSTTTHHHHHHH CS
    MreB_Mbl 262 ektppeLaadivdrgivltGGgallkgldkllseetglp.vkvaedpltcvakGtg 316
                 ++   +  +  +d  +vl+GG++ +  ++++l+e ++ +    + +p ++va G++
  EFC36488.1 323 QDSGLD--KSQID-DVVLVGGSTRIPKVQEMLKEFFNGKeLCKSINPDEAVAYGAA 375
                 *98755..44455.48899***************9976515556799999999986 PP

>> Hydantoinase_A  Hydantoinase/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.1   7.7e-06      0.02      22     103 ..     138     220 ..     120     240 .. 0.73
   2 ?    1.9   0.0     0.042   1.1e+02     224     283 ..     313     375 ..     269     379 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 7.7e-06
  Hydantoinase_A  22 vekslekrgakarlmvmqsdGglv.sadearkkpvetilSGPaaGvvgaaatsklagekkvItfDmGGTstDvsl..ikdgevev 103
                     + k+++k+ ++ + ++ +s+   + +a ++ +  v  i+  P a ++++    +++ge++v+ fD+GG ++Dvs   i+dg +ev
      EFC36488.1 138 LGKQVKKAVVTVPAYFNDSQRQATkDAGAIAGLEVLRIINEPTAAAIAYGL--NKKGERNVLIFDLGGGTFDVSIlnIEDGVFEV 220
                     566677777777777777776544256677777788888899999999888..99*****************9962255666665 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.042
  Hydantoinase_A 224 nmanavrklsvergldpkeltlvvfGGaG...aqhaaalaeelgvkkvivppyagvlsalGma 283
                     n  ++v+k++++ gld+++   vv  G++   + + ++l e ++ k+      +  ++a+G+a
      EFC36488.1 313 NCFEPVKKVLQDSGLDKSQIDDVVLVGGStriPKVQEMLKEFFNGKELCKSINPDEAVAYGAA 375
                     56789***************9888777663555566667777777777777777777777766 PP

>> DDR  Diol dehydratase reactivase ATPase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.6   0.1   0.00015      0.39     132     166 ..     193     226 ..     125     229 .. 0.85
   2 ?    3.2   0.0     0.014        35     257     296 ..     312     353 ..     286     363 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00015
         DDR 132 ekplailDlGaGstDaalieeegevkavhlAGAGe 166
                 e+++ i DlG+G+ D ++++ e+ v  v  A AG+
  EFC36488.1 193 ERNVLIFDLGGGTFDVSILNIEDGVFEVK-ATAGD 226
                 56799***************999998864.77776 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.014
         DDR 257 tnalRalkkvsptg..nirdidfvvlvGgsalDfEipelvtd 296
                 +n++  +kkv   +  +  +id vvlvGgs+    ++e++++
  EFC36488.1 312 RNCFEPVKKVLQDSglDKSQIDDVVLVGGSTRIPKVQEMLKE 353
                 566666666644331145689*********998888888876 PP

>> kleA_kleC  Uncharacterized KorC regulated protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.3   0.00021      0.55      23      55 ..     509     540 ..     500     556 .. 0.81
   2 ?    0.5   0.0       0.3   7.6e+02       7      27 ..     576     597 ..     572     602 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00021
   kleA_kleC  23 RdkiAaklaeAeeLvrqaeeLRakvyeesaaLe 55 
                 +++i ++l++Ae+++ q +eLR+kv  +   Le
  EFC36488.1 509 KEEIDEMLRQAENMKAQDDELRKKVEAK-NHLE 540
                 689*********************9654.4455 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.3
   kleA_kleC   7 pWiDeLpeva.tdlvarRdkiA 27 
                  WiD+ + ++ +++ a+  ++ 
  EFC36488.1 576 NWIDNNQTASkEEFEAKQKELE 597
                 7********9999*99998875 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.2     0.008        21       1      32 [.       9      38 ..       9     155 .. 0.73
   2 ?    5.6   0.1    0.0084        22       4      89 ..     200     358 ..     197     378 .. 0.63
   3 ?    2.3   0.3     0.084   2.2e+02      32      60 ..     499     531 ..     483     611 .. 0.64

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.008
                EEEEE-SSSEEEEEEETTEEEEEEEES-.-HHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx RF
        FtsA  1 alvDiGagktdvavaedgalvhlrvigv.ggng 32
                +++D+G++ ++v v+ ++   ++++++  +gn 
  EFC36488.1  9 IGIDLGTTYSCVGVYMGD---NVEIVPNdQGNR 38
                58***************7...777777655544 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0084
                 EE-SSSEEEEEEETTEEEE..........EEEES--HHHHHHH......................HHHHHT--HHHHHHHHHHH--S--.......... CS
                 xxxxxxxxxxxxxxxxxxx..........xxxxxxxxxxxxxx......................xxxxxxxxxxxxxxxxxxxxxxxx.......... RF
        FtsA   4 DiGagktdvavaedgalvh..........lrvigvggngitkd......................iakalrtaveeAerikikyGsala.......... 60 
                 D+G+g+ dv++++ +  v+          l     gg+ +++                       + + lrt+ e A+r   + +   +          
  EFC36488.1 200 DLGGGTFDVSILNIEDGVFevkatagdthL-----GGEDFDNRmvdfccqefkrkhkkdlqenprALRRLRTSCERAKRNLSSAA---Nasinvdsimd 290
                 899999999999886533344444333330.....55555555555555555555888899988878888888888888773333...22335555555 PP

                 ....EEEEEHHHHH...........................................GGGGSTTHHHHHHHHHT-. CS
                 ....xxxxxxxxxx...........................................xxxxxxxxxxxxxxxxxxx RF
        FtsA  61 ....ekeigrkels...........................................ggsalpnleelaeralspk 89 
                     +                                                    g++ +p+++e++++ ++ k
  EFC36488.1 291 gidlD--------ItmtrakfeqmnmdmfrncfepvkkvlqdsgldksqiddvvlvgGSTRIPKVQEMLKEFFNGK 358
                 55441........044445555666777778888888888888888888888899999999999999999998543 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.084
                 HHHHH....HHHHHT--HHHHHHHHHHH--S-- CS
                 xxxxx....xxxxxxxxxxxxxxxxxxxxxxxx RF
        FtsA  32 gitkd....iakalrtaveeAerikikyGsala 60 
                  it+d     ++ + + + +Ae++k ++  + +
  EFC36488.1 499 TITNDkgrlSKEEIDEMLRQAENMKAQDDELRK 531
                 5777777766778999999******54332222 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   5.8    0.0021       5.3     113     221 ..     486     598 ..     476     613 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0021
     DUF4407 113 aeeqqeeakelkeqlaaa....ltaelaeleaqiaalqaeidaaearldalraeaqkeldgtkgtgttgvaGkgpaake..kkaqldaaqaelaelkak 205
                 a++++++ k+ + +++++    +++e++e+ +q ++++a+ d+++++++a++      ++ +++ + ++ aGk p+ ++   k++ +aa + +++ ++ 
  EFC36488.1 486 AAKDESSGKTENITITNDkgrlSKEEIDEMLRQAENMKAQDDELRKKVEAKNHLESYAYQMKSTVEDPNLAGKIPESDKktIKEACEAAINWIDNNQTA 584
                 445555555555566666899999****************************9999999999999999********98833456666666666666666 PP

     DUF4407 206 ldatarlaalraelae 221
                   ++++++a+++el++
  EFC36488.1 585 --SKEEFEAKQKELEG 598
                 ..77777777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (656 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1496  (0.0834402); expected 358.6 (0.02)
Passed bias filter:                      819  (0.0456802); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.82u 0.36s 00:00:01.18 Elapsed: 00:00:00.56
# Mc/sec: 3528.39
//
Query:       EFC36489.1  [L=117]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00014   21.7   0.1     0.0063   16.3   0.0    2.0  2  DUF1837   Domain of unknown function (DUF1837)
  ------ inclusion threshold ------
      0.015   14.3   0.1      0.018   14.0   0.1    1.1  1  PGK       Phosphoglycerate kinase
      0.034   14.2   0.1      0.044   13.9   0.1    1.2  1  AHH       A nuclease family of the HNH/ENDO VII superfamily w


Domain annotation for each model (and alignments):
>> DUF1837  Domain of unknown function (DUF1837)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   1.1e-06    0.0063      84     142 ..       3      72 ..       1      80 [. 0.73
   2 !    3.7   0.1    0.0074        44      91     112 ..      85     105 ..      80     114 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.1e-06
     DUF1837  84 vkgaDgvhikvdddgklqLwlGeSKlysdlksa...............ideaveslkkflnedslnkelnlisn 142
                  +g+D v+i+++++   +L+++eSKl+++ ++                ++++v+ +k++ n+   +   +li++
  EFC36489.1   3 SNGFDHVYIDKKTG---NLIILESKLTTKSNNPtygtsgghkqgtkeyVNDVVQRMKES-NQPMTKIAAQLIER 72 
                 58***********9...9********665444445566688888777788888777777.55555555555555 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0074
     DUF1837  91 hikvdddgklqLwlGeSKlysd 112
                 h k++++g+ +++lG  K+y++
  EFC36489.1  85 HTKMEENGD-FMVLGNTKFYKK 105
                 555566665.**********86 PP

>> PGK  Phosphoglycerate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.1   2.9e-06     0.018      62     123 ..      56     111 ..      10     116 .. 0.52

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.9e-06
                 S-GGG-SHHHHHHH.HHHH.TT-EEEESSTTSHHHHHHHHT-TTT-EEEES-GGGSTTTTTT-H CS
         PGK  62 ekeklslkpvaerL.sell.gkeVkfvedvvgeeveeaiaelkegevllLeNvrfykeEeknde 123
                 ++++  ++++a++L ++ + + +V fv   +     ++ +  ++g+ ++L N++fyk+E   +e
  EFC36489.1  56 KESNQPMTKIAAQLiERKVsEGKVDFV---I-----HHTKMEENGDFMVLGNTKFYKKEGPTRE 111
                 223333444444443222223355555...2.....23345689***************65544 PP

>> AHH  A nuclease family of the HNH/ENDO VII superfamily with conserved AHH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   7.3e-06     0.044      46     104 ..      11      70 ..       3      85 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 7.3e-06
         AHH  46 inda.eNgvlLPekkeaslklglpgHrgsHteeYsklVrerldeikkeakekklkkealk 104
                 i++   N+++L +k  ++ ++ + g +g H++   ++V++ ++++k++++ +++  ++l+
  EFC36489.1  11 IDKKtGNLIILESKLTTKSNNPTYGTSGGHKQGTKEYVNDVVQRMKESNQPMTKIAAQLI 70 
                 555558*****9999999999999******9999999999999**9*9999999777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (117 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       910  (0.0507558); expected 358.6 (0.02)
Passed bias filter:                      584  (0.0325729); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 700.40
//
Query:       EFC36490.1  [L=204]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.035   14.5  16.0       0.89   10.0   0.2    3.2  3  V-SNARE         Vesicle transport v-SNARE protein N-terminus
        0.1   11.9   8.1        6.1    6.1   7.0    2.1  2  DUF3450         Protein of unknown function (DUF3450)
       0.11   11.8   1.8       0.17   11.2   1.8    1.3  1  DUF4407         Domain of unknown function (DUF4407)
        0.3   10.9   9.6       0.41   10.5   7.8    2.2  2  DivIC           Septum formation initiator
       0.41   11.3  13.7      0.081   13.5   9.0    2.0  2  HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interac
       0.49   11.1   7.4       0.27   12.0   5.0    1.7  2  DUF2203         Uncharacterized conserved protein (DUF2203)
        6.8    6.9   9.4         35    4.6   6.4    2.1  2  DUF4047         Domain of unknown function (DUF4047)
        9.2    5.7  14.0         36    3.8  14.0    1.8  1  Exonuc_VII_L    Exonuclease VII, large subunit


Domain annotation for each model (and alignments):
>> V-SNARE  Vesicle transport v-SNARE protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.2    0.0004      0.89      25      74 ..      22      71 ..      17      76 .. 0.94
   2 ?    5.1   0.6     0.014        31      21      50 ..      90     119 ..      72     130 .. 0.76
   3 ?    6.1   5.6    0.0065        15      16      54 ..     129     168 ..     118     175 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.0004
     V-SNARE 25 aalreiekkldeaeelldqMelEvrnlpsserasykaklreykselkklk 74
                + +r++ +++++ e ll+++e   + l    r+++++ +++ +s+lk+++
  EFC36490.1 22 KSIRNLSQDFKSSEGLLESFETLKQALEVFLRNQISNNVEDERSDLKNFR 71
                7899***********************99******************976 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.014
     V-SNARE  21 eerkaalreiekkldeaeelldqMelEvrn 50 
                 e+  + l e+ kk++ea+ l+ +M+l  +n
  EFC36490.1  90 ESDFSRLVELVKKVEEAQMLVIRMDLKKKN 119
                 666677888899*************98776 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0065
     V-SNARE  16 sslag.eerkaalreiekkldeaeelldqMelEvrnlpss 54 
                  + +  e +k +++ +++++++ ++ l+++ lE+++l  +
  EFC36490.1 129 EKDEEiEAKKNQIKSLQNEIESKRQELKNLTLELKDLYNT 168
                 34444589**************************999533 PP

>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0    0.0064        14      62     107 ..      12      57 ..       5      61 .. 0.91
   2 ?    6.1   7.0    0.0027       6.1      29     104 ..     100     181 ..      91     185 .. 0.62

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0064
     DUF3450  62 slevyneqlerlvasqeqeiasleeqieeieeierelvpllekmid 107
                 sl  +n++ +++++++ q+++s e  +e++e ++++l+ +l++ i+
  EFC36490.1  12 SLGTFNNNGTKSIRNLSQDFKSSEGLLESFETLKQALEVFLRNQIS 57 
                 677899999*******************************998775 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0027
     DUF3450  29 vaaaaqsqkkidklddekqellaeyralkeeleslevyneq...lerlvasqeqeiasleeqieeieei...erelvpllek 104
                 v++ +++q  + ++d +k++ l + ++  e+ e++e++++q   l++ ++s +qe+++l+ +++++ ++   e++lv l+ k
  EFC36490.1 100 VKKVEEAQMLVIRMDLKKKNKLIRNKRNLEKDEEIEAKKNQiksLQNEIESKRQELKNLTLELKDLYNTkksEDQLVGLMNK 181
                 6666777777888887777666666665555555655555511156666777777777777777665441115677777766 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   1.8   7.6e-05      0.17     125     171 ..     126     170 ..      97     198 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 7.6e-05
     DUF4407 125 eqlaaa.ltaelaeleaqiaalqaeidaaearldalraeaqkeldgtk 171
                 ++      ++e+++ ++qi++lq+ei++++++l++l+ e+++ ++ +k
  EFC36490.1 126 RN---LeKDEEIEAKKNQIKSLQNEIESKRQELKNLTLELKDLYNTKK 170
                 22...1378899999999999999999999999999999998888665 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2      0.66   1.5e+03      42      70 ..     120     131 ..      97     137 .. 0.56
   2 ?   10.5   7.8   0.00018      0.41      19      52 ..     134     167 ..     125     174 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.66
                 HHHHHHCC-XXXXXXXXXXXXXXXXXXXX CS
       DivIC  42 eLeaevkdLksdedyieerARselglvkp 70 
                 +L ++ ++L                  k+
  EFC36490.1 120 KLIRNKRNL-----------------EKD 131
                 222222333.................222 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00018
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-XX CS
       DivIC  19 ykqlkqeiaalqaelaklkaeneeLeaevkdLks 52 
                 + ++k++i+ lq+e++++++e ++L+ e+kdL +
  EFC36490.1 134 IEAKKNQIKSLQNEIESKRQELKNLTLELKDLYN 167
                 5567888888888888888888888888888866 PP

>> HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interacting protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.1      0.82   1.8e+03      45      45 ..      50      50 ..      21      83 .. 0.55
   2 ?   13.5   9.0   3.6e-05     0.081       6      85 ..      88     175 ..      86     185 .. 0.61

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.82
  HIP1_clath_bdg 45 r 45
                     
      EFC36490.1 50 V 50
                    1 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 3.6e-05
  HIP1_clath_bdg   6 rKnAevtkqlsvarq.aqeeverekkeleee..lerlke..eaerkleeqkeelekLkreleakraelarlkssLe...sseqsgeql 85 
                     r + +  +++   ++ +  ++   + +l+++  l r k+  e+++++e +k ++++L++e+e+kr+el++l   L+   ++++s++ql
      EFC36490.1  88 RNESDFSRLVELVKKvEEAQMLVIRMDLKKKnkLIRNKRnlEKDEEIEAKKNQIKSLQNEIESKRQELKNLTLELKdlyNTKKSEDQL 175
                     5666666666544431333444555555544004444432256667779**********************98876222455555555 PP

>> DUF2203  Uncharacterized conserved protein (DUF2203)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       2.1   4.7e+03      31      31 ..      43      43 ..      18      73 .. 0.44
   2 ?   12.0   5.0   0.00012      0.27      14      86 ..      98     165 ..      90     176 .. 0.46

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.1
     DUF2203 31 e 31
                +
  EFC36490.1 43 T 43
                1 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 0.00012
     DUF2203  14 llkelleelralrkeleeleeeleeakaeaekseaaeleaeleeleaeieelveeieelGvevkdleaglvDF 86 
                 +l +++ee++ l  ++     +l+++++  +++   e+ +e+e+ +++i++l +eie+   e+k+l   l D 
  EFC36490.1  98 ELVKKVEEAQMLVIRM-----DLKKKNKLIRNKRNLEKDEEIEAKKNQIKSLQNEIESKRQELKNLTLELKDL 165
                 3333333333322222.....3333333333333445555555555555555555555555555554444444 PP

>> DUF4047  Domain of unknown function (DUF4047)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1      0.04        89      53      96 ..      35      82 ..      17     102 .. 0.67
   2 ?    4.6   6.4     0.016        35      45      99 ..     117     171 ..      93     181 .. 0.79

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.04
     DUF4047 53 klkvdsveeieqalsvw..kqgrekikaerealqk..vyteieepynq 96
                +   +s e ++qal+v+  +q  + +  er  l++  +   i   +n+
  EFC36490.1 35 EGLLESFETLKQALEVFlrNQISNNVEDERSDLKNfrISFVIKSKFNK 82
                44568999*****99874234467888899988872233345556655 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.016
     DUF4047  45 heyeemksklkvdsveeieqalsvwkqgrekikaerealqkvyteieepynqvqe 99 
                 ++ + ++ k + +  eeie + ++ k  ++ i + r+ l+++  e+ + yn  + 
  EFC36490.1 117 KKNKLIRNKRNLEKDEEIEAKKNQIKSLQNEIESKRQELKNLTLELKDLYNTKKS 171
                 345567788999999***********************************97654 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8  14.0     0.016        36     155     262 ..      51     188 ..      10     196 .. 0.48

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.016
  Exonuc_VII_L 155 rlekaikrll.............................eekkqrleklasrlkspeellerk....rqrldeleerleralkkqlkkkrerleelk 218
                    l+++i++++                             e+  +rl +l ++++++++l+ r     +++l + +++le+  ++++++k++++++l+
    EFC36490.1  51 FLRNQISNNVedersdlknfrisfvikskfnkkpsplrnESDFSRLVELVKKVEEAQMLVIRMdlkkKNKLIRNKRNLEK--DEEIEAKKNQIKSLQ 145
                   33344444442111211111112222222233333322211222233333333333332222211002222222333333..444666666666666 PP

  Exonuc_VII_L 219 erlkekleekkerlkklkerle...lleekkerleeleeklealspl 262
                       +++e+k+++lk+l+ +l+   ++++++++l  l++k+++ +p+
    EFC36490.1 146 ----NEIESKRQELKNLTLELKdlyNTKKSEDQLVGLMNKISLDQPS 188
                   ....5556666777777666666555666667777777777766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (204 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2899  (0.161693); expected 358.6 (0.02)
Passed bias filter:                      657  (0.0366445); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 1146.74
//
Query:       EFC36491.1  [L=1156]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      8e-26   91.0   2.2      8e-26   91.0   2.2    3.5  4  Pkinase         Protein kinase domain
    5.3e-23   81.6   0.7    4.4e-22   78.6   0.3    2.6  2  Pkinase_Tyr     Protein tyrosine kinase
    1.4e-16   61.0   3.8    2.4e-16   60.2   0.7    3.0  2  Dynamin_N       Dynamin family
    1.3e-10   41.4   3.4    1.7e-10   41.0   1.0    2.6  2  MMR_HSR1        50S ribosome-binding GTPase
    0.00041   19.8   0.2        1.1    8.6   0.0    2.7  2  Arf             ADP-ribosylation factor family
    0.00043   20.8   3.0     0.0043   17.6   0.1    3.4  2  ABC_tran        ABC transporter
     0.0016   17.3   0.1      0.005   15.7   0.1    1.8  1  Pkinase_fungal  Fungal protein kinase
     0.0042   16.6   0.0     0.0042   16.6   0.0    3.3  4  FeoB_N          Ferrous iron transport protein B
  ------ inclusion threshold ------
      0.013   15.0   6.6       0.77    9.3   0.4    4.3  3  GTP_EFTU        Elongation factor Tu GTP binding domain
      0.033   13.3   0.4       0.19   10.7   0.0    2.3  2  T2SSE           Type II/IV secretion system protein
        0.1   12.8   5.0       0.45   10.8   5.0    2.1  1  IBR             IBR domain, a half RING-finger domain
       0.23   11.5   3.8       0.33   11.0   0.7    2.9  2  efb-c           Extracellular fibrinogen binding protein C te
        1.1    9.0   6.0        8.6    6.1   0.1    4.0  4  PduV-EutP       Ethanolamine utilisation - propanediol utilis
          2    8.7   6.9         12    6.2   0.0    3.9  4  Roc             Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1      0.72   9.3e+02      54      86 ..     136     168 ..      88     196 .. 0.76
   2 ?   -1.0   0.4      0.71   9.1e+02     207     250 ..     630     681 ..     602     685 .. 0.60
   3 !   91.0   2.2   6.3e-29     8e-26       5     194 ..     884    1070 ..     880    1076 .. 0.87
   4 ?   -1.3   0.0      0.85   1.1e+03     234     254 ..    1072    1092 ..    1070    1099 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.72
                 HHSCTTB--EEEEEEESSEEEEEEE--TTEBHH CS
     Pkinase  54 klkhpnivrlyevfeekdelylvleyveggela 86 
                 +++ + i+  ye f++ ++ ++++ y + + l+
  EFC36491.1 136 NVNLQDIIDQYELFKTATSKHIITPYFNRTFLE 168
                 566777888888888888888888888766544 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.71
                 HHHHHTHHHHHHHCT.....SHH...HHHTTS...............-HHHHHHHHHHT-SSGC CS
     Pkinase 207 ekeldqlekilkilg.....etkeklpeasei...............seeakdllkkllkkdpk 250
                  ++l+q   i+++++                                s e+k++lk+ +++dpk
  EFC36491.1 630 IQDLRQ--DIIEVFErtssqS----------SskkieeamhiihtkvSVEFKEFLKERIAQDPK 681
                 333333..4444444332221..........012223345557777799999999999998886 PP

  == domain 3  score: 91.0 bits;  conditional E-value: 6.3e-29
                  EEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE....SSEEEEEEE--TTEBHHHHHHHHSS--H CS
     Pkinase    5 eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee....kdelylvleyveggeladllerkgslse 97  
                  e  G+G+fGk y+       +i A+K i++ k  +     + rE+ +  +l+h +iv+ + + +e      + y+ +ey++++ l ++   ++ ++ 
  EFC36491.1  884 EFCGHGAFGKTYRLN-----NITAIKYISTIKLAEH---ILDRELFYNSQLSHAHIVKSMLIKKEetenALNGYIYQEYLPQT-LSQWAL-NKPINY 970 
                  5679********988.....7*******99887774...579****************988877744334456799*****77.666664.689*** PP

                  HHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH...TT.SCBSHHHHHHHHHHHHHHH CS
     Pkinase   98 eeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl...ke.neyskkvDvWslGvilyel 190 
                  ++a ++a +i+ g++y+ s +i+HrDl ++Ni+id+ +++Ki+D+G+ake+  +   t   g  + +APEv    ++   y+  +Dv+s G+++ el
  EFC36491.1  971 KKALRYACEIALGMKYIQSCNIMHRDLDKSNIMIDKFDHIKIIDLGVAKEMVDNA-HTANQGKYKTMAPEVKrsgSDfAIYDFRCDVYSFGIVVKEL 1066
                  *****************************************************98.9999************654224778**************** PP

                  HHSS CS
     Pkinase  191 ltgk 194 
                  l g 
  EFC36491.1 1067 LDGY 1070
                  9875 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.85
                  -HHHHHHHHHHT-SSGCCSTT CS
     Pkinase  234 seeakdllkkllkkdpkkRlt 254 
                  s+e+  ll+++l+kd k+R++
  EFC36491.1 1072 SSEISLLLERCLEKDFKNRIG 1092
                  788999*************86 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.48   6.2e+02     144     172 ..     334     362 ..     327     366 .. 0.90
   2 !   78.6   0.3   3.4e-25   4.4e-22       8     201 ..     887    1069 ..     880    1123 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.48
                  E-STTTHEETTTSSEEEETTSSTSGGGGS CS
  Pkinase_Tyr 144 isDfGLardiekddeyvkkeeaklpvkWm 172
                  +s fG++++++++++  ++++++++v+W 
   EFC36491.1 334 VSTFGVSEKTKSEQKKDRESQKTIRVHWD 362
                  789*******9999999999999****95 PP

  == domain 2  score: 78.6 bits;  conditional E-value: 3.4e-25
                   EEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT.CTTTSBH CS
  Pkinase_Tyr    8 GeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk.ekekltl 102 
                   G+GafGk ++ +            a+K ++  + +e  + l +e+   ++l+h +ivk + +  +e +   +  y+ +  L + L +   ++++++
   EFC36491.1  887 GHGAFGKTYRLNNI---------TAIKYISTIKLAE--HILDRELFYNSQLSHAHIVKSMLIKKEETE-NALNGYIYQEYLPQTLSQWaLNKPINY 970 
                   66666666554433.........7888885544444..66778999999*********9988775444.445666666666666665423568*** PP

                   HHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE....EEHHHHHHHHHHH CS
  Pkinase_Tyr  103 kdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk....ftsksDvWsfGvl 194 
                   k+ l++a ++A Gm+y++s +++Hrdl   N+++++ +++ki D G+a+++   d  ++++ ++  +k mapE+ ++++    +  + Dv+sfG++
   EFC36491.1  971 KKALRYACEIALGMKYIQSCNIMHRDLDKSNIMIDKFDHIKIIDLGVAKEM--VD--NAHTANQGKYKTMAPEVKRSGSdfaiYDFRCDVYSFGIV 1062
                   **************************************************9..33..334445567889*****999988899************* PP

                   HHHHHTT CS
  Pkinase_Tyr  195 lwEiftl 201 
                   + E++  
   EFC36491.1 1063 VKELLDG 1069
                   ***9973 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.2   0.7   1.9e-19   2.4e-16       2     167 ..     257     456 ..     256     457 .. 0.83
   2 ?   -1.0   0.1       1.2   1.6e+03      59      86 ..     609     636 ..     593     706 .. 0.63

  Alignments for each domain:
  == domain 1  score: 60.2 bits;  conditional E-value: 1.9e-19
                 EEEEBTTTTHHHHHHHHHTS--S---SSS---S-EEEEECCT---CCS...SSEEEET-EB--CHHHHHHHHHHHHHHHTSSSS--SS........... CS
   Dynamin_N   2 avvGsqSsGKSSvlnaLlgedilprgpnptTrrplelqlgeeeeaseravkeelkekekkledfsevreeieketekiagankgiskk........... 89 
                 +vvG ++sGK++++na+lg ++lp++++ +T + +el++ +  +     +k+e+ke++  ++ +s+++ e+ ++ e i ++  +   +           
  EFC36491.1 257 CVVGITNSGKTTLMNAILGMNLLPSKEGRCTIANTELRYADYDK-----RKIEIKEEHGTFNTLSQFTSEYLMQHESIPEEVVS---Tfgvsektkseq 347
                 59*************************************98666.....77778888777777777777766666666633332...222244577777 PP

                 .........-EEEEEEETTS-SEEEEE---B-SSSGTTS.....................HHHHHHHSTTEEEEEEEETTS-CCC-.CHHHHHHHHSTT CS
   Dynamin_N  90 .........villkilsllvkgltlvDlPGldsvnkrdq.....................elvkeyikkadiilavtsanhdlsns.ealflarevdpk 157
                          + ++ +  ll+ g+ + D+PG+d++ +++                        + e+i+++ ++++v++ nh  +++  +l+l +  + k
  EFC36491.1 348 kkdresqktIRVHWDSLLLKTGIAFSDTPGYDDIYEEEVlfntykrqskkkalpknvmvnPQTLEFIQESELVILVVDINHTYTSKdAVLNLLDIDELK 446
                 8888888888888899999*******************9******************999999******************999984567777777778 PP

                 BTTEEEEEE- CS
   Dynamin_N 158 gkrtivvltk 167
                 gk ++vv++k
  EFC36491.1 447 GKQIMVVMNK 456
                 8889999988 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.2
                 T-EB--CHHHHHHHHHHHHHHHTSSSS- CS
   Dynamin_N  59 ekkledfsevreeieketekiagankgi 86 
                 +k+led+s + e+++++ ++i + + ++
  EFC36491.1 609 KKQLEDISSLVEKFRERIQQIIQDLRQD 636
                 5555555555555555544444333222 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       7.8   9.9e+03      63      86 ..      98     121 ..      93     153 .. 0.57
   2 !   41.0   1.0   1.3e-13   1.7e-10       2     114 .]     256     456 ..     255     456 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 7.8
                 HHHHHHHHHHHHCTSEEEEEEETT CS
    MMR_HSR1  63 ekglgkaflaleeadlillvvdas 86 
                 +++++++++++++ d++ l +  +
  EFC36491.1  98 QWNINEDYQQNIQQDVMQLFIVTN 121
                 567777778777766644433222 PP

  == domain 2  score: 41.0 bits;  conditional E-value: 1.3e-13
                 EEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEE.ETTEE.................................................... CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvk.lkgke.................................................... 47 
                 +++vG +N+GK+tL+na++g +   s++  +T+  +e r++ ++  +                                                    
  EFC36491.1 256 CCVVGITNSGKTTLMNAILGMNLLPSKEGRCTIANTELRYAdYD--Krkieikeehgtfntlsqftseylmqhesipeevvstfgvsektkseqkkdre 352
                 79******************999999999999999999887322..1357788888999999999999999**************************** PP

                 .................EEEEECGGC............SSHHHHHH......HHHHHHHH.HHCTSEEEEEEETTTTCSHHHHHHHHHHHHH..TTSEE CS
    MMR_HSR1  48 .................ielvDtpGl............iegaseek......glgkafla.leeadlillvvdaseeklkpldeeleellee..akkpl 108
                                  i + DtpG             ++++s++k      +++ + l+ ++e++l++lvvd++ ++++ +d  l+ l  +  ++k++
  EFC36491.1 353 sqktirvhwdslllktgIAFSDTPGYddiyeeevlfntYKRQSKKKalpknvMVNPQTLEfIQESELVILVVDIN-HTYTSKDAVLNLLDIDelKGKQI 450
                 *************************444444443333323333333122233333333334777*********99.66888765544333224589999 PP

                 EEEEES CS
    MMR_HSR1 109 ilvlnk 114
                 ++v+nk
  EFC36491.1 451 MVVMNK 456
                 99*998 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0    0.0009       1.1      11      34 ..     250     273 ..     241     283 .. 0.84
   2 !    8.2   0.0    0.0012       1.6      78     134 ..     413     466 ..     408     472 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0009
                 .TTEEEEEEEESTTSSHHHHHHHH CS
         Arf  11 kkkelrilllGLDnaGKtTilkkl 34 
                 +k+ +++ ++G+ n+GKtT+++ +
  EFC36491.1 250 SKNPMKCCVVGITNSGKTTLMNAI 273
                 47789***************9865 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0012
                 GCTTESEEEEEEETT-CTTHHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HH CS
         Arf  78 YfektdavifvvDsadreRleeakeeLkalleeeelkevallvlaNKqDlpealsee 134
                 + ++ + vi vvD +++    ++k+ + +ll+ +elk  +++v+ NK  + +++ ++
  EFC36491.1 413 FIQESELVILVVDINHT---YTSKDAVLNLLDIDELKGKQIMVVMNKCNMFGSIGKR 466
                 56777889999998876...57899999*******************9998887665 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.1   3.4e-06    0.0043      14     102 ..     256     347 ..     249     370 .. 0.66
   2 ?    1.0   0.4      0.42   5.4e+02      42     102 ..     604     676 ..     590     691 .. 0.48

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 3.4e-06
                 EEEEESTTSSHHHHHHHHTTSS--..SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSB.HHHH...HHHTCHHHHHHHSTTGGTTCBGE CS
                 xxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx...xxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkp..teGeilldgkdlkeqeleslrkeigvlpqepqlfpelt.vren...esdeeiekalsklglkelkdtvv 102
                   +vG + +GK+tL+++++g+     +eG+ ++ +++l++      +++i++ +++   f++l+   ++   + ++ +e+++s++g +e++++ +
  EFC36491.1 256 CCVVGITNSGKTTLMNAILGMNLLpsKEGRCTIANTELRY--ADYDKRKIEIKEEH-GTFNTLSqFTSEylmQHESIPEEVVSTFGVSEKTKSEQ 347
                 5689999***********99754445**************..33333444433333.33333331222244444455666666666666444444 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.42
                 EEET.TCEGGG..B-HHHCCHCEEEE-SS--S-TTSBHHHH..........HHHTCHHHHHHHSTTGGTTCBGE CS
                 xxxx.xxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxx..........xxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  42 illd.gkdlke..qeleslrkeigvlpqepqlfpeltvren..........esdeeiekalsklglkelkdtvv 102
                 ++l+ +k+l++     e++r++i+ + q+   ++ ++v e+          e+  +i +   +++ ke+ ++++
  EFC36491.1 604 MQLEkKKQLEDisSLVEKFRERIQQIIQD-LRQDIIEVFERtssqssskkiEEAMHIIHTKVSVEFKEFLKERI 676
                 55553444555654456666666666666.22222335555444422442222222333333333344555554 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.1   3.9e-06     0.005     324     387 ..     988    1042 ..     972    1062 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3.9e-06
  Pkinase_fungal  324 lkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlk 387 
                      + ++i+HrD    Ni+i      + ++  +iDL +ake+ d +++ +     G  + ma ev +
      EFC36491.1  988 QSCNIMHRDLDKSNIMID-----KFDHIKIIDLGVAKEMVD-NAHTA---NQGKYKTMAPEVKR 1042
                      589**************9.....678899***********7.44443...45666666666666 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   3.2e-06    0.0042       2      74 ..     255     329 ..     254     343 .. 0.82
   2 ?   -2.2   0.2       2.1   2.7e+03      79     115 ..     417     457 ..     403     466 .. 0.52
   3 ?   -2.7   0.0         3   3.8e+03     111     127 ..     515     531 ..     511     543 .. 0.87
   4 ?   -1.9   0.1       1.6   2.1e+03     122     155 ..    1109    1142 ..    1097    1144 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 3.2e-06
                 EEEEEESTTSSHHHHHHHHHTTSEEEEESTTSSSEEEEEEEE.ETTEEEEEEE----SS.SSSSSHHHHHHHHHH CS
      FeoB_N   2 tvalvGnpnvGkttlfnaltgakqkvgNwpGvtvekkegklk.lkgkeveivDlPGiYs.lsayseeekvardfl 74 
                 ++++vG  n+Gkttl+na+ g++   +     t+ ++e ++  ++++++ei    G+++ ls++++e  + ++ +
  EFC36491.1 255 KCCVVGITNSGKTTLMNAILGMNLLPSKEGRCTIANTELRYAdYDKRKIEIKEEHGTFNtLSQFTSEYLMQHESI 329
                 6899********************99999999*9999887651566999**999999963677777766655555 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2.1
                 SSEEEEEEEGGGHHHHHHH...HHHHHHTT.SSEEEEEETH CS
      FeoB_N  79 pdvvvnvvdatnlernLyL...tlqllelg.vpvvlalnmi 115
                  ++v+ vvd ++   +      +l++ el+ +++++++n++
  EFC36491.1 417 SELVILVVDINHTYTSKDAvlnLLDIDELKgKQIMVVMNKC 457
                 45555555554443332220012334444324555556655 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3
                 EEETHHHHHHTTEEE-H CS
      FeoB_N 111 alnmideaekkgieidl 127
                  ln id +++kgi++++
  EFC36491.1 515 LLNHIDMMSTKGISVNQ 531
                 69***********9985 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 1.6
                  TEEE-HHHHHHHHTS-EEEEBTTTTBTHHHHHHH CS
      FeoB_N  122 gieidlkkLsekLgvpvvktsakkkegieellka 155 
                  +++++ ++ s++L+++v +++ +++ +ie l+k+
  EFC36491.1 1109 ELDVEPTEYSNQLKIEVQEVQEESQIDIEVLKKE 1142
                  5566667778888888888888888888888765 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.4    0.0006      0.77       4      48 ..     254     303 ..     251     391 .. 0.57
   2 ?    3.9   0.0     0.027        35      93     136 ..     416     471 ..     409     570 .. 0.61
   3 ?    0.3   0.1      0.33   4.2e+02      16      46 ..     740     771 ..     739     785 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0006
                 EEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH...HHHST.....HCHSHH CS
    GTP_EFTU   4 rnigiighvDhGKtTLtdrLlyktgaiskkgeka...eeerv.....lDtlke 48 
                 ++++++g +++GKtTL+ ++l  +   sk+g+ +   +          D++k 
  EFC36491.1 254 MKCCVVGITNSGKTTLMNAILGMNLLPSKEGRCTianT---ElryadYDKRKI 303
                 689*****************977766666555444321...123455333333 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.027
                 T-SEEEEEEETTTBSTHHHHHHHHHHHHTTTE...EEEEEESCGST..........H CS
    GTP_EFTU  93 vlDgavlvvdaveGvepqteevlrlalkegvp...iivfiNKmDrl..........k 136
                   ++++lvvd+++  +++   vl+l+   +++   i+v++NK+ +            
  EFC36491.1 416 ESELVILVVDINHTYTSK-DAVLNLLDIDELKgkqIMVVMNKCNMFgsigkredrgW 471
                 56899*******986654.4455555544444446********99866655444332 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.33
                 HHHHHHHHHHHTTSSCHHHHHHHH.HSTHCHS CS
    GTP_EFTU  16 KtTLtdrLlyktgaiskkgekaee.ervlDtl 46 
                 K+ ++d+L+yk+++i+ ++e+ ++ e+ +D  
  EFC36491.1 740 KSNIIDELVYKSERIQVSEEESDSaENDTDDV 771
                 999*************9888885435556655 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00015      0.19     128     188 ..     252     312 ..     199     319 .. 0.66
   2 ?   -0.9   0.1      0.55     7e+02     182     203 ..     779     804 ..     741     807 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00015
       T2SSE 128 erglilvsGgTgsGKttllyall..keinksderivtvEDpvEiqleganqvqlnakkakvtf 188
                 + +   v G T sGKttl++a+l  + +++++ r  ++    E++ ++ ++ +++ k+++ tf
  EFC36491.1 252 NPMKCCVVGITNSGKTTLMNAILgmNLLPSKEGRCTIAN--TELRYADYDKRKIEIKEEHGTF 312
                 44566799*************983245666655544443..3555555555555555445555 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.55
       T2SSE 182 k....kakvtfadllraaLRlrPDri 203
                      ++++++++++++++   PD+ 
  EFC36491.1 779 LlaldSQNLDVNQVIQKIMQSYPDMF 804
                 24445789****************86 PP

>> IBR  IBR domain, a half RING-finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   5.0   0.00035      0.45      23      53 ..      30      68 ..      12      71 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00035
         IBR 23 rpdCeaiieksegcks........vtCskCgfefCfnCk 53
                +p C +++e+++ +++        + C++C+  fC nC+
  EFC36491.1 30 SPTCANFAEQQDVEEDhdyhtnvnIYCPHCKSFFCENCH 68
                689*****999994444778887788************8 PP

>> efb-c  Extracellular fibrinogen binding protein C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1       2.7   3.4e+03      28      41 ..     178     191 ..     175     203 .. 0.64
   2 ?   11.0   0.7   0.00026      0.33      10      55 ..     628     676 ..     621     682 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2.7
       efb-c  28 aaHRkAqkAvnLvs 41 
                 +   kAq  vn  s
  EFC36491.1 178 SIFHKAQEQVNKFS 191
                 56678888888654 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00026
       efb-c  10 klvd..AqklvreFkktrtvaaHRkAqkAvnLvsFeykvk.kkkLqeri 55 
                 ++++   q++++ F++t   ++ +k   A+ +++ + +v+ k  L+eri
  EFC36491.1 628 QIIQdlRQDIIEVFERTSSQSSSKKIEEAMHIIHTKVSVEfKEFLKERI 676
                 455523499******************************9677899998 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.089   1.1e+02      74     116 ..     152     195 ..     136     214 .. 0.75
   2 ?    6.1   0.1    0.0067       8.6       3      26 ..     255     278 ..     254     291 .. 0.85
   3 ?   -0.3   0.2      0.64   8.2e+02      53     107 ..     689     743 ..     679     753 .. 0.85
   4 ?   -3.4   0.0       5.7   7.3e+03      61      93 ..     781     813 ..     776     826 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.089
   PduV-EutP  74 teeesvfppgfasvfnkeviGiitkidlaed.eenieaveelLk 116
                  +++++++p f ++f  ++  i+ ki++ ++ +e++++  e++k
  EFC36491.1 152 ATSKHIITPYFNRTFLEPLTPICEKISIFHKaQEQVNKFSEMFK 195
                 45567888999999999999999999886541566776666655 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0067
   PduV-EutP   3 killiGkvgsGKttLtqalkgeel 26 
                 k  ++G ++sGKttL++a+ g +l
  EFC36491.1 255 KCCVVGITNSGKTTLMNAILGMNL 278
                 56789*************988776 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.64
   PduV-EutP  53 lysalivtsaeadvialvqdateeesvfppgfasvfnkeviGiitkidlaedeen 107
                 +  +++++++  ++i l  ++     ++p  f  v+ k ++ ++t + + ++++ 
  EFC36491.1 689 YIISITIFAIPISIILLGIAVLLVPVLMPIMFPYVMVKTILDMVTDLKKKKKSNI 743
                 66788899999999999999999999999****************9998866554 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 5.7
   PduV-EutP  61 saeadvialvqdateeesvfppgfasvfnkevi 93 
                 +++++ + + q +++ ++ +p+ f+  ++k++i
  EFC36491.1 781 ALDSQNLDVNQVIQKIMQSYPDMFCLEIEKHLI 813
                 556666666666777788999999999998877 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.2       5.2   6.7e+03      81      81 ..     113     113 ..      80     143 .. 0.52
   2 ?    6.2   0.0     0.009        12       1      29 [.     255     283 ..     255     312 .. 0.77
   3 ?   -2.5   0.1       4.5   5.8e+03      25      62 ..     330     362 ..     321     363 .. 0.58
   4 ?    4.2   0.1     0.037        47      76     119 ..     413     458 ..     406     459 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 5.2
                 C CS
         Roc  81 a 81 
                  
  EFC36491.1 113 V 113
                 1 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.009
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEE CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekek 29 
                 K ++vG +++GKt+l++ ++  +  ++++
  EFC36491.1 255 KCCVVGITNSGKTTLMNAILGMNLLPSKE 283
                 7899*************998877665554 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 4.5
                 C-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEE CS
         Roc  25 sekekstigvdfltkevtkikgvendkkvkkvklniWD 62 
                  e+  st+gv+ +tk+     + ++++++k++++  WD
  EFC36491.1 330 PEEVVSTFGVSEKTKSE----QKKDRESQKTIRV-HWD 362
                 45667899998887753....2233344455555.366 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.037
                 HHCTSCEEEEEEE.GHHHHCHHHHHHHHHHH.CSSS-EEEEEE-TT CS
         Roc  76 ylreaalailvyd.srssenlkeWlkelkkv.agkspvilvgnkiD 119
                 +++e++l+ilv+d ++++++ +  l+ l+    + +++++v+nk++
  EFC36491.1 413 FIQESELVILVVDiNHTYTSKDAVLNLLDIDeLKGKQIMVVMNKCN 458
                 8999*********544556666666665533145678999****97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1906  (0.106308); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.99u 0.37s 00:00:01.36 Elapsed: 00:00:00.55
# Mc/sec: 6304.13
//
Query:       EFC36492.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00011   22.0   0.0    0.00024   21.0   0.0    1.5  1  Phage_integrase  Phage integrase family


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   1.3e-08   0.00024      32     162 ..     163     304 ..     133     312 .. 0.68

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.3e-08
                      HHT--HHHHTT-BGGGEECTTTEE.EEE.......EEECSSSSEEEEECTHHHHHHHHHHHHHH....CHCCTTTSBSSBETTSSB--HHHHHH CS
  Phage_integrase  32 etGlRisEllsLrvkdldlengvi.lvh.......eregKgskeravplseealellkellska....leeaeksellfaskrgkplsrqtvrk 113
                      +  +R + l++L++++++l+   i +v        + ++   k+  +  +ee+ + ++ +  +     +  +e+++ lf    ++  +  +++ 
       EFC36492.1 163 RLLARPGQLANLSWSCVKLDTPFIgWVTfdlsghkTDQLSDMKKLLLNHKEEIRNTVQFITLEDmdyvKHIKEDDSPLFSLLFDEYFTPTQISN 256
                      5567888999999999988887654664444433322222222222222233333333332222555566677777777777888889999999 PP

                      HHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHHHHT-SSCCH CS
  Phage_integrase 114 afkraveeagiekpltpHtlRhsfataLleagvdlrvvqkllGHssist 162
                      ++++     g++ ++++H+lR s+at+L+ +gv+++ ++ ++++   s 
       EFC36492.1 257 IISSPMSSIGVQ-NTSGHSLRISAATKLASKGVSQSMIETAGNWVPNSK 304
                      999999999999.*****************************9976655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 2149.42
//
Query:       EFC36493.1  [L=648]
Description: very long-chain acyl-CoA synthetase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      4e-54  183.8   0.0    3.9e-52  177.3   0.0    2.2  2  AMP-binding  AMP-binding enzyme


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.0   0.00071        13       5      41 ..      55      95 ..      51     100 .. 0.81
   2 !  177.3   0.0   2.1e-56   3.9e-52      38     418 ..     110     502 ..     108     506 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.00071
                 HHHSTTSEEEEE....CCSTEEEEHHHHHHHHHHHHHHHHH CS
  AMP-binding  5 aaktpdkvalvd....sgegqtlTYreldervnrlAagLrs 41
                 a+++ dk a+       +++  +TY+ +++ +n+lA +L +
   EFC36493.1 55 ARTYSDKLAIQTvhkpIDTQPVITYEKMNQMANQLAYYLIN 95
                 6777888888556777667888*****************86 PP

  == domain 2  score: 177.3 bits;  conditional E-value: 2.1e-56
                  HHHHTTSSTT-EEEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHHTESEEE...........E.TCTCCC.HHHHHHHHSCC-EECE CS
  AMP-binding  38 gLrslGvkkgdrVaillpnspewvvallailkaGavvvplnptltaeelayiledseakvli...........a.tvdsel.leklleaaakleavkl 122
                  gL ++ +++gd+V +l++n   ++ ++ ++ k+G++++ +n+ lt++++++++e s+ak ++           a + ++++   ++++a       + 
   EFC36493.1 110 GLSNHIMTQGDVVCLLMENNENFIPTWGGLNKLGLTIACINTYLTPDRMKHAIELSGAKSIFlsrkmlplfekArN-EEQEfEISIRKAS-----IRD 201
                  566556799*****************************************************99887776643121.1222122222222.....222 PP

                  EEEESCCS-HCCHCCCHCCCCSCTTS-TSCCCS-BTTSEEEEEEE--SSSS-EEEEEEHHHHHHHHHHHHHHHCSCCTTT-EEEESS-TTSCHHHHHH CS
  AMP-binding 123 vivldadellkeeelkeeeeseekaekpeeeeelkpddlayiiYTSGTTGkPKGVmlshrnlvanvaslkletrfklkeddvvlsilplahifglile 220
                    v   +++ k+e+ ++ e++++          ++ +d ++ iYTSGTTGk K +  s r ++ +  +++++   +l +dd+++  lpl+h  g +++
   EFC36493.1 202 FKVFIVEDIIKYENCNTLENPNSTI----YRGDITGEDALLYIYTSGTTGKSKCARFSNRRFIGAGVTWSVQ--MDLVKDDKYYIALPLYHGNGGVVA 293
                  2222234677777777777666443....3346899***********************9998887775433..445589****************** PP

                  HHHHHHTT-EEEE-TTCGCCHHHHHHHHHHHHT-SEEEEEHHHHHHHHHCCCHHCHHHHCCGTT.-SEEEEESS-EBHHHHHHHHHHHTC.EEEEEEE CS
  AMP-binding 221 lllallsGatvvllpkdaaldpklllelieklkvtviagvPrvleallesgalkaakkakdlss.lrlvllggeplspellrffralfge.evlegYG 316
                  + +++l+G+t vl +k++a +   +l++i+++++t + ++ +++++l + ++++      d +  lr+  ++g+ l+++++ ++ ++fg  +++e YG
   EFC36493.1 294 VSAIMLVGGTAVLREKFSASN---FLNDIRTFGCTATIYIGELWRYLYNTPEKE-----DDAQNpLRV--AAGNGLRKDIWNRVMKRFGIkKIVEHYG 381
                  *****************9944...67***********************76555.....377777**9..79*****************999****** PP

                  EGGGSSEC.EECHCTTTCTSTTS-BEE-....TTEEEEEE...-TTTSCBEE...........TTSEEEEEEEETTS-SEBTT-HHHHHHHEEE..T. CS
  AMP-binding 317 lTEttgvv.tvlpleedkkklgsvGkpl....pgvevkiv...Deetgepvp...........dgeeGellvrgpgvmkgYlkkpeataeafds..e. 392
                  +TE++ +  + +   ++ +k+gs+G++      +++ +++   D et    +           +g+ Ge + r   + k Y ++++  ++++ +  e 
   EFC36493.1 382 QTEMLSAHpM-I---NSYNKVGSCGFIPfdlwTNQKKEVLltyDFETDSVKRdpvtgfceiagPGVAGEDVTRISELYKAYNNHEDNLKKVYRDvfEk 475
                  *****99743.3...455689****55223333444444444666655444467778888888*********************99999999888845 PP

                  CC.EEEEEEEEEEETTSEEEEEEECCC CS
  AMP-binding 393 gr.wlrTGDlgrldedGyleivgRkkd 418
                  g+ w+r+GDl ++d dG +++v+R+ +
   EFC36493.1 476 GDmWYRSGDLLKFDNDGFFYFVDRLGE 502
                  788*********************865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (648 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       725  (0.0404373); expected 358.6 (0.02)
Passed bias filter:                      564  (0.0314574); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 4157.57
//
Query:       EFC36494.1  [L=369]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.17   12.1   0.0       0.39   10.9   0.0    1.6  1  CH        Calponin homology (CH) domain


Domain annotation for each model (and alignments):
>> CH  Calponin homology (CH) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   2.2e-05      0.39      12      87 ..     228     302 ..     227     318 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 2.2e-05
                 HHHHTTSTTSSTTSCHHHHHTTSHHHHHHHHHHSTTTSSGGGSTTTHHHHHHHHHHHHHHHHHHTTCHTTSS.-HHH CS
          CH  12 nshleeagpkvkvedfeedlrDGvlLckLlnklapglvdkkklnksefkkleNinlaldvaekklgvpkvli.eaed 87 
                 n+ ++ +  ++ + d ++  +DG+ +c+L+ ++ p   +++k n   + +  N++ + ++ +k+l +++ l+  ++d
  EFC36494.1 228 NDDTAVSYIHKGCCDITKHTCDGTGYCNLIIAFPPLNAEFAKDN--SHGYNINCKSFDSLKKKTLTFSQQLTyPTAD 302
                 555666667888899******************99888888775..6666666666665555555555555544444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (369 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 2229.91
//
Query:       EFC36495.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.4e-36  120.2   4.1     0.0004   20.2   0.0    7.4  7  LRR_6      Leucine Rich repeat
      2e-21   75.5  10.3    2.6e-07   30.3   0.2    4.4  5  LRR_8      Leucine rich repeat
    5.5e-17   61.6  11.7    0.00018   21.9   0.2    5.7  6  LRR_4      Leucine Rich repeats (2 copies)
    1.3e-10   40.3   1.7        2.4    9.0   0.0    7.9  8  LRR_1      Leucine Rich Repeat
  ------ inclusion threshold ------
       0.12   12.9   0.0        6.6    7.3   0.0    2.5  2  DUF3707    Pherophorin
       0.12   12.4  12.7         15    5.6   0.1    6.5  7  ApoB100_C  Apolipoprotein B100 C terminal


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.4e-07    0.0004       5      23 ..     128     146 ..     125     147 .. 0.91
   2 !   18.8   0.0   3.7e-07    0.0011       5      22 ..     152     169 ..     150     170 .. 0.91
   3 !   14.7   0.0   7.9e-06     0.024       5      24 .]     176     195 ..     173     195 .. 0.92
   4 !   18.6   0.0   4.5e-07    0.0013       5      23 ..     200     218 ..     197     219 .. 0.89
   5 !   12.3   0.1   4.5e-05      0.14       5      24 .]     224     243 ..     221     243 .. 0.92
   6 !   12.8   0.0   3.1e-05     0.092       5      22 ..     248     265 ..     245     266 .. 0.91
   7 !   16.6   0.0   1.9e-06    0.0056       5      18 ..     272     285 ..     269     291 .. 0.90

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.4e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+ gN+Ig eGa+ +
  EFC36495.1 128 LTSLDIGGNQIGAEGAKFI 146
                 9***************977 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 3.7e-07
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+L++s+N+Ig +G++ 
  EFC36495.1 152 LTSLNISYNQIGAKGVKF 169
                 9**************985 PP

  == domain 3  score: 14.7 bits;  conditional E-value: 7.9e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L++L++ gN+Ig eG++ ++
  EFC36495.1 176 LKSLNIIGNQIGAEGVKLIS 195
                 9***************9985 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 4.5e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L +L++ gN+IgDeG++ +
  EFC36495.1 200 LASLNIGGNQIGDEGVKFI 218
                 679*************966 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 4.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++  N Ig eGa+ ++
  EFC36495.1 224 LTSLNICLNRIGAEGAKLIS 243
                 9****************985 PP

  == domain 6  score: 12.8 bits;  conditional E-value: 3.1e-05
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+ +N Ig eG++ 
  EFC36495.1 248 LTSLDICYNRIGTEGVKF 265
                 9***************85 PP

  == domain 7  score: 16.6 bits;  conditional E-value: 1.9e-06
       LRR_6   5 LteLdLsgNdIgDe 18 
                 L++L++sgN+IgDe
  EFC36495.1 272 LKSLNISGNQIGDE 285
                 9************9 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.3       2.6   7.8e+03      30      37 ..      19      26 ..      17      28 .. 0.53
   2 !   21.4   0.1   5.2e-08   0.00016      10      61 .]     110     162 ..     102     162 .. 0.90
   3 !   23.9   0.3   8.8e-09   2.6e-05       2      61 .]     151     210 ..     150     210 .. 0.98
   4 !   30.3   0.2   8.9e-11   2.6e-07       2      61 .]     223     282 ..     222     282 .. 0.98
   5 !   26.0   0.0     2e-09   5.8e-06       2      55 ..     247     300 ..     246     300 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.6
                EE--SS-- CS
       LRR_8 30 LdLsnNll 37
                L ++nN++
  EFC36495.1 19 LMINNNNM 26
                55555554 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 5.2e-08
                 TS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  10 nNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +  l s+++  F + +++L++Ld++ N++    ++ +s  ++L+sL++s+N++
  EFC36495.1 110 RKLLDSIEQAKFINeMKQLTSLDIGGNQIGAEGAKFISEVKQLTSLNISYNQI 162
                 456999999999999************************************97 PP

  == domain 3  score: 23.9 bits;  conditional E-value: 8.8e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++s N++ + + ++   +++Lk+L++  N++     + +s +++L sL++ gN++
  EFC36495.1 151 QLTSLNISYNQIGAKGVKFIIEMKQLKSLNIIGNQIGAEGVKLISEMKQLASLNIGGNQI 210
                 7*********************************************************98 PP

  == domain 4  score: 30.3 bits;  conditional E-value: 8.9e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL+++ Nr+ + + +  + +++L++Ld+ +N++ t   + ++ +++L+sL++sgN++
  EFC36495.1 223 QLTSLNICLNRIGAEGAKLISEMKQLTSLDICYNRIGTEGVKFIREMKQLKSLNISGNQI 282
                 7*********************************************************98 PP

  == domain 5  score: 26.0 bits;  conditional E-value: 2e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 +LtsLd++ Nr+   + ++ + +++Lk+L++s N++   +++ +s +++L+sL+
  EFC36495.1 247 QLTSLDICYNRIGTEGVKFIREMKQLKSLNISGNQIGDEEAKFISEMKQLTSLN 300
                 7**************************************************997 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.2       3.6   1.1e+04       6      13 ..      19      26 ..      17      28 .. 0.64
   2 !   11.1   0.0   0.00014      0.42      12      36 ..     112     138 ..     105     142 .. 0.75
   3 !   17.7   0.1   1.2e-06    0.0037       1      36 [.     150     186 ..     150     195 .. 0.82
   4 !   13.1   0.1   3.3e-05     0.099       2      32 ..     199     230 ..     198     238 .. 0.82
   5 !   12.0   0.2   7.2e-05      0.22       1      36 [.     222     258 ..     222     264 .. 0.83
   6 !   21.9   0.2   5.9e-08   0.00018       1      38 [.     246     284 ..     246     306 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.6
                EE--SS-- CS
       LRR_4  6 LdLsnNql 13
                L ++nN++
  EFC36495.1 19 LMINNNNM 26
                56677765 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00014
                 ---E-S-..HHH.-TT--EEE-.-S--- CS
       LRR_4  12 qltdipl..lek.lpnLkeLdLsgNnli 36 
                  l +i+   + + +++L++Ld+ gN +i
  EFC36495.1 112 LLDSIEQakFINeMKQLTSLDIGGN-QI 138
                 6778888774455*********778.77 PP

  == domain 3  score: 17.7 bits;  conditional E-value: 1.2e-06
                 SS--EEE--SS---.E-S-....HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqlt.dipl....leklpnLkeLdLsgNnli 36 
                 ++L++L++s Nq+  +  +    +  +++Lk+L++ gN +i
  EFC36495.1 150 KQLTSLNISYNQIGaK--GvkfiI-EMKQLKSLNIIGN-QI 186
                 58************43..336534.5*********999.76 PP

  == domain 4  score: 13.1 bits;  conditional E-value: 3.3e-05
                 S--EEE--SS---E-S-...HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsg 32 
                 +L +L++++Nq+ d +    le +++L++L++  
  EFC36495.1 199 QLASLNIGGNQIGDEGVkfiLE-MKQLTSLNI-C 230
                 5778**********999*8777.********8.2 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 7.2e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L++  N++   +  l + +++L++Ld+  N +i
  EFC36495.1 222 KQLTSLNICLNRIGAEGAkLISeMKQLTSLDICYN-RI 258
                 589******88***777796655********9788.65 PP

  == domain 6  score: 21.9 bits;  conditional E-value: 5.9e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+  N++ + +   ++ +++Lk+L++sgN +i+d
  EFC36495.1 246 KQLTSLDICYNRIGTEGVkfIREMKQLKSLNISGN-QIGD 284
                 579******99*99888896556*********999.8876 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1       1.1   3.1e+03       7      15 ..      58      66 ..      52      71 .. 0.79
   2 ?    4.9   0.0     0.019        56       1      13 [.     127     139 ..     127     148 .. 0.81
   3 ?    5.4   0.0     0.013        39       1      12 [.     151     162 ..     151     171 .. 0.83
   4 ?    2.0   0.0      0.16   4.9e+02       1      12 [.     175     186 ..     175     196 .. 0.78
   5 ?    2.9   0.0     0.082   2.4e+02       2      16 ..     200     214 ..     199     221 .. 0.78
   6 ?    0.4   0.0      0.55   1.6e+03       1      12 [.     223     234 ..     223     244 .. 0.79
   7 ?    4.5   0.0     0.025        75       1      13 [.     247     259 ..     247     268 .. 0.81
   8 !    9.0   0.0   0.00082       2.4       1      18 [.     271     288 ..     271     293 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1  7 Lsnnpllgl 15
                L+n++l+++
  EFC36495.1 58 LNNCSLISK 66
                899999755 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.019
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+++n+++
  EFC36495.1 127 QLTSLDIGGNQIG 139
                 599*******984 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++s+n++
  EFC36495.1 151 QLTSLNISYNQI 162
                 599*******98 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++ +n++
  EFC36495.1 175 QLKSLNIIGNQI 186
                 59****988876 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.082
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L +L++++n++++ +
  EFC36495.1 200 LASLNIGGNQIGDEG 214
                 669******997655 PP

  == domain 6  score: 0.4 bits;  conditional E-value: 0.55
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L+++ n++
  EFC36495.1 223 QLTSLNICLNRI 234
                 599****88876 PP

  == domain 7  score: 4.5 bits;  conditional E-value: 0.025
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+++n+++
  EFC36495.1 247 QLTSLDICYNRIG 259
                 599*******984 PP

  == domain 8  score: 9.0 bits;  conditional E-value: 0.00082
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L++s+n++++ ++ 
  EFC36495.1 271 QLKSLNISGNQIGDEEAK 288
                 59*********9877665 PP

>> DUF3707  Pherophorin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.0    0.0022       6.6      65     118 ..     126     179 ..      41     199 .. 0.74
   2 ?    3.3   0.0     0.038   1.1e+02      87     123 ..     220     255 ..     195     269 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0022
     DUF3707  65 gsvkgvtvngsstspswaasgenvlkitnLnltlnktqaagaeiClelknpttl 118
                 ++++++++ g+++ ++ a++ ++v ++t+Ln++ n+  a+g +  +e+k+  +l
  EFC36495.1 126 KQLTSLDIGGNQIGAEGAKFISEVKQLTSLNISYNQIGAKGVKFIIEMKQLKSL 179
                 4455555555554445555555999999****999999*********9954444 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.038
     DUF3707  87 nvlkitnLnltlnktqaagaeiClelknpttlsdlCs 123
                 ++ ++t+Ln+ ln+  a+ga++  e+k + t  d+C+
  EFC36495.1 220 EMKQLTSLNICLNRIGAEGAKLISEMK-QLTSLDICY 255
                 555789999999999************.578889993 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.1    0.0051        15       9      32 ..     108     133 ..     106     137 .. 0.87
   2 ?    2.4   0.1     0.051   1.5e+02      19      32 ..     144     157 ..     135     179 .. 0.85
   3 ?    1.8   0.0     0.081   2.4e+02      19      32 ..     192     205 ..     177     209 .. 0.85
   4 ?   -0.4   0.0      0.37   1.1e+03      12      32 ..     209     229 ..     207     230 .. 0.81
   5 ?    0.1   0.0      0.27     8e+02      19      32 ..     240     253 ..     232     258 .. 0.87
   6 ?   -1.2   0.0      0.68     2e+03      19      32 ..     264     277 ..     251     282 .. 0.81
   7 ?    4.1   0.1     0.016        46      11      30 ..     280     299 ..     270     309 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0051
   ApoB100_C   9 fsdqlsdyyE..kliaeskrLiDLsI 32 
                 fs +l+d+ E  k+i+e k+L  L I
  EFC36495.1 108 FSRKLLDSIEqaKFINEMKQLTSLDI 133
                 7889999988778********98876 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.051
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  L I
  EFC36495.1 144 KFISEVKQLTSLNI 157
                 99******999988 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.081
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 kli+e k+L  L I
  EFC36495.1 192 KLISEMKQLASLNI 205
                 9********99988 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.37
   ApoB100_C  12 qlsdyyEkliaeskrLiDLsI 32 
                 q+ d   k+i e k+L  L I
  EFC36495.1 209 QIGDEGVKFILEMKQLTSLNI 229
                 66666679********98877 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.27
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 kli+e k+L  L I
  EFC36495.1 240 KLISEMKQLTSLDI 253
                 99******988876 PP

  == domain 6  score: -1.2 bits;  conditional E-value: 0.68
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i e k+L  L I
  EFC36495.1 264 KFIREMKQLKSLNI 277
                 99999999987776 PP

  == domain 7  score: 4.1 bits;  conditional E-value: 0.016
   ApoB100_C  11 dqlsdyyEkliaeskrLiDL 30 
                 +q+ d   k+i+e k+L  L
  EFC36495.1 280 NQIGDEEAKFISEMKQLTSL 299
                 79999999********9866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       967  (0.053935); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 1857.62
//
Query:       EFC36496.1  [L=114]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.5e-25   87.0   0.3    2.4e-06   27.2   0.0    4.3  4  LRR_6      Leucine Rich repeat
    2.1e-18   66.1  12.4    1.6e-06   28.3   0.2    3.1  4  LRR_4      Leucine Rich repeats (2 copies)
    1.6e-11   43.7   4.9    3.6e-07   29.8   0.3    2.2  2  LRR_8      Leucine rich repeat
    8.9e-08   31.7   0.1        2.4    9.0   0.0    4.4  5  LRR_1      Leucine Rich Repeat
    0.00014   21.8   2.8        8.4    6.4   0.1    4.0  4  ApoB100_C  Apolipoprotein B100 C terminal
    0.00026   20.5   2.1      0.003   17.1   0.3    2.0  2  LRR_9      Leucine-rich repeat
     0.0029   17.5   0.2        2.3    8.0   0.0    3.0  3  DUF4347    Domain of unknown function (DUF4347)
     0.0079   16.3   0.7        2.2    8.4   0.1    2.5  2  NKWYS      Putative capsular polysaccharide synthesis protein
  ------ inclusion threshold ------
      0.028   14.2   2.6        1.3    8.8   0.1    2.0  2  UPF0193    Uncharacterised protein family (UPF0193)
      0.048   14.0   2.8        2.6    8.5   0.1    2.9  3  CLU_N      Mitochondrial function, CLU-N-term


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   0.0   1.3e-09   2.4e-06       5      23 ..       4      22 ..       2      23 .. 0.92
   2 !   20.4   0.0   1.9e-07   0.00035       5      24 .]      28      47 ..      26      47 .. 0.93
   3 !   18.6   0.0   7.1e-07    0.0013       5      23 ..      52      70 ..      49      71 .. 0.91
   4 !   15.8   0.0   5.8e-06      0.01       5      24 .]      76      95 ..      73      95 .. 0.93

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 1.3e-09
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+L++s+N+IgDeG++ +
  EFC36496.1  4 LTSLNISYNQIGDEGVKFI 22
                9***************987 PP

  == domain 2  score: 20.4 bits;  conditional E-value: 1.9e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                L++Ld+  N+IgDeGa+ ++
  EFC36496.1 28 LKSLDIYNNQIGDEGAKLIS 47
                9****************986 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 7.1e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+L++  N+IgDeGa+ +
  EFC36496.1 52 LTALNIYNNQIGDEGAKFI 70
                9***************987 PP

  == domain 4  score: 15.8 bits;  conditional E-value: 5.8e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++ +N Ig eG++ L+
  EFC36496.1 76 LTALNIYSNRIGTEGVKLLS 95
                9****************986 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.2   9.2e-10   1.6e-06       1      38 [.       2      40 ..       2      47 .. 0.89
   2 !   27.2   0.3   2.1e-09   3.7e-06       1      38 [.      26      64 ..      26      67 .. 0.90
   3 !   20.9   0.1   1.9e-07   0.00034       1      36 [.      50      86 ..      50      92 .. 0.86
   4 !   13.3   0.3   4.9e-05     0.087       1      39 [.      74     113 ..      74     114 .] 0.83

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 9.2e-10
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38
                ++L++L++s Nq+ d +  + + +++Lk+Ld+  Nn+i+d
  EFC36496.1  2 KQLTSLNISYNQIGDEGVkFISeIKQLKSLDI-YNNQIGD 40
                58*************99996655*********.888*987 PP

  == domain 2  score: 27.2 bits;  conditional E-value: 2.1e-09
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38
                ++L++Ld+ nNq+ d +  l + +++L+ L++  Nn+i+d
  EFC36496.1 26 KQLKSLDIYNNQIGDEGAkLISeMKQLTALNI-YNNQIGD 64
                58*************99996655*********.888*987 PP

  == domain 3  score: 20.9 bits;  conditional E-value: 1.9e-07
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36
                ++L+ L++ nNq+ d +  + + +++L+ L++ +N +i
  EFC36496.1 50 KQLTALNIYNNQIGDEGAkFISeMKQLTALNIYSN-RI 86
                589************999*6655*********777.66 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 4.9e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L+ L++ +N++ + +   l+ +++L+ L + +N + +++
  EFC36496.1  74 KQLTALNIYSNRIGTEGVklLSEMKQLTALVI-NNQQMKSI 113
                 589***********988896556*******99.77676666 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.8   0.3     2e-10   3.6e-07       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   22.0   0.6   5.6e-08    0.0001       2      58 ..      51     107 ..      50     110 .. 0.95

  Alignments for each domain:
  == domain 1  score: 29.8 bits;  conditional E-value: 2e-10
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsL++s N++ + + ++ +  ++Lk+Ld+ nN++    ++ +s +++L+ L++ +N++
  EFC36496.1  3 QLTSLNISYNQIGDEGVKFISEIKQLKSLDIYNNQIGDEGAKLISEMKQLTALNIYNNQI 62
                7*********************************************************97 PP

  == domain 2  score: 22.0 bits;  conditional E-value: 5.6e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +Lt L++ nN++ + + ++ + +++L+ L++ +N++ t   + +s +++L+ L +++
  EFC36496.1  51 QLTALNIYNNQIGDEGAKFISEMKQLTALNIYSNRIGTEGVKLLSEMKQLTALVINN 107
                 79***************************************************9987 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0    0.0021       3.7       1      16 [.       3      18 ..       3      24 .. 0.80
   2 !    9.0   0.0    0.0014       2.4       1      18 [.      27      44 ..      27      49 .. 0.80
   3 ?    5.7   0.0     0.016        29       2      19 ..      52      69 ..      51      73 .. 0.79
   4 ?    3.3   0.0      0.11   1.9e+02       2      14 ..      76      88 ..      75      97 .. 0.77
   5 ?   -3.0   0.0        10   1.8e+04       2      10 ..     100     108 ..      99     110 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0021
       LRR_1  1 nLrhLdLsnnpllglp 16
                +L++L++s+n++++ +
  EFC36496.1  3 QLTSLNISYNQIGDEG 18
                599********97665 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0014
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++Ld+ nn++++ ++ 
  EFC36496.1 27 QLKSLDIYNNQIGDEGAK 44
                59*********9877665 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.016
       LRR_1  2 LrhLdLsnnpllglppns 19
                L+ L++ nn++++ ++  
  EFC36496.1 52 LTALNIYNNQIGDEGAKF 69
                999*******98776655 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.11
       LRR_1  2 LrhLdLsnnpllg 14
                L+ L++ +n+++ 
  EFC36496.1 76 LTALNIYSNRIGT 88
                999******9854 PP

  == domain 5  score: -3.0 bits;  conditional E-value: 10
       LRR_1   2 LrhLdLsnn 10 
                 L+ L ++n+
  EFC36496.1 100 LTALVINNQ 108
                 777888876 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.1    0.0077        14       9      32 ..      10      33 ..       4      38 .. 0.85
   2 !    6.3   0.1    0.0053       9.5      10      34 ..      35      59 ..      29      62 .. 0.84
   3 !    6.4   0.1    0.0047       8.4      11      33 ..      60      82 ..      58     102 .. 0.83
   4 ?    3.1   0.0      0.05        90      19      34 ..      92     107 ..      83     110 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0077
   ApoB100_C  9 fsdqlsdyyEkliaeskrLiDLsI 32
                 ++q+ d   k+i+e k+L  L I
  EFC36496.1 10 SYNQIGDEGVKFISEIKQLKSLDI 33
                6899999999*********88877 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0053
   ApoB100_C 10 sdqlsdyyEkliaeskrLiDLsIek 34
                 +q+ d   kli+e k+L  L I +
  EFC36496.1 35 NNQIGDEGAKLISEMKQLTALNIYN 59
                479999999*********9999865 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0047
   ApoB100_C 11 dqlsdyyEkliaeskrLiDLsIe 33
                +q+ d   k+i+e k+L  L I 
  EFC36496.1 60 NQIGDEGAKFISEMKQLTALNIY 82
                68888889*********999885 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.05
   ApoB100_C  19 kliaeskrLiDLsIek 34 
                 kl++e k+L  L+I++
  EFC36496.1  92 KLLSEMKQLTALVINN 107
                 8999999999999988 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.3   1.7e-06     0.003      43     125 ..       3      86 ..       1      88 [. 0.86
   2 !   10.1   0.2   0.00024      0.43      63     103 ..      73     113 ..      66     114 .] 0.92

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 1.7e-06
       LRR_9  43 qfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 q+ ++++s n+i +  +  +  +k+lk+l + nn+i   + +l   + +l++l + nn++ + +  + + ++k+l+ l + +n +
  EFC36496.1   3 QLTSLNISYNQIGDegVKFISEIKQLKSLDIYNNQIGDEGAKLISEMKQLTALNIYNNQIGDEGA-KFISEMKQLTALNIYSNRI 86 
                 66778888888864225556678999***********************************9988.999**********999876 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00024
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqel 103
                 +k+l +l + +nri   + +l   + +l++lv++n++++++
  EFC36496.1  73 MKQLTALNIYSNRIGTEGVKLLSEMKQLTALVINNQQMKSI 113
                 89999********************************9976 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0    0.0029       5.2      85     121 ..      23      57 ..       3      62 .. 0.74
   2 !    8.0   0.0    0.0013       2.3      87     124 ..      49      84 ..      44      90 .. 0.78
   3 ?    4.2   0.0      0.02        35      86     121 ..      72     105 ..      67     111 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0029
     DUF4347  85 ealsedadillYgCnvAageaGeafvekLaqltgadv 121
                 +++++ + + +Y  +++ +  G +++++++qlt  ++
  EFC36496.1  23 SEIKQLKSLDIYNNQIGDE--GAKLISEMKQLTALNI 57 
                 5667777888888888765..9999999999999887 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0013
     DUF4347  87 lsedadillYgCnvAageaGeafvekLaqltgadvaAs 124
                 +++   + +Y  +++   +G +f+++++qlt  ++ ++
  EFC36496.1  49 MKQLTALNIYNNQIGD--EGAKFISEMKQLTALNIYSN 84 
                 5556677788888876..5**************99765 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.02
     DUF4347  86 alsedadillYgCnvAageaGeafvekLaqltgadv 121
                 ++++   + +Y+ +++ +  G +++++++qlt   +
  EFC36496.1  72 EMKQLTALNIYSNRIGTE--GVKLLSEMKQLTALVI 105
                 566677788899998876..9999999999997765 PP

>> NKWYS  Putative capsular polysaccharide synthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.1    0.0012       2.2      37      71 ..      21      55 ..      19      70 .. 0.74
   2 !    5.9   0.1    0.0071        13      37      80 ..      69     112 ..      57     114 .] 0.86

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0012
       NKWYS 37 FDnElkknlgiDvfnkdfdkdegfvifnnkkfsll 71
                F  E+k++ ++D++n+++ ++    i + k+   l
  EFC36496.1 21 FISEIKQLKSLDIYNNQIGDEGAKLISEMKQLTAL 55
                6689**************87665555555555555 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0071
       NKWYS  37 FDnElkknlgiDvfnkdfdkdegfvifnnkkfslllikseklde 80 
                 F  E+k++++++++ + +  +    + + k+   l+i  +++++
  EFC36496.1  69 FISEMKQLTALNIYSNRIGTEGVKLLSEMKQLTALVINNQQMKS 112
                 678***************9876666777888999***9999986 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.4    0.0052       9.2     170     207 ..      17      54 ..      11      62 .. 0.89
   2 ?    8.8   0.1   0.00071       1.3     170     206 ..      65     101 ..      58     111 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0052
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 e ++F++e ++L   + Y++ I +e ++ + e+++l  
  EFC36496.1  17 EGVKFISEIKQLKSLDIYNNQIGDEGAKLISEMKQLTA 54 
                 5679******************************9975 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00071
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklreleald 206
                 e ++F++eM++L   + Y++ I te  + l e+++l 
  EFC36496.1  65 EGAKFISEMKQLTALNIYSNRIGTEGVKLLSEMKQLT 101
                 5689******************************986 PP

>> CLU_N  Mitochondrial function, CLU-N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.1     0.048        86      19      44 ..       2      30 ..       1      45 [. 0.67
   2 ?    1.3   0.0      0.25   4.5e+02      14      30 ..      45      61 ..      41      69 .. 0.74
   3 ?    8.5   0.1    0.0015       2.6      14      51 ..      69     109 ..      67     114 .] 0.82

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.048
       CLU_N 19 kylTnyhLkye..ng.ngerlnefvtlse 44
                k+lT+ ++ y+  ++   + ++e ++l+ 
  EFC36496.1  2 KQLTSLNISYNqiGDeGVKFISEIKQLKS 30
                89******998543323344466666654 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.25
       CLU_N 14 elpstkylTnyhLkyen 30
                +++++k+lT  ++++++
  EFC36496.1 45 LISEMKQLTALNIYNNQ 61
                5788999**99996642 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0015
       CLU_N  14 elpstkylTnyhLkye..ng.ngerlnefvtlseiieeedv 51 
                 +++++k+lT  +++ +  ++   + l+e+++l  ++ ++++
  EFC36496.1  69 FISEMKQLTALNIYSNriGTeGVKLLSEMKQLTALVINNQQ 109
                 67899********9989866688999*******99888865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       427  (0.0238162); expected 358.6 (0.02)
Passed bias filter:                      213  (0.0118802); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 778.26
//
Query:       EFC36497.1  [L=747]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      3e-62  203.7   0.0    3.5e-08   33.1   0.0   11.8 12  NHL             NHL repeat
    3.3e-18   66.2   0.7    1.7e-06   27.8   0.0    5.5  3  SGL             SMP-30/Gluconolactonase/LRE-like region
    5.2e-08   33.0   8.8        4.1    7.7   0.0    8.1  9  Arylesterase    Arylesterase
    7.5e-07   29.0  14.6     0.0047   16.9   0.0    7.0  7  SBBP            Beta-propeller repeat
    2.3e-06   27.8   1.7       0.95    9.3   0.0    6.1  6  Phytase-like    Esterase-like activity of phytase
    0.00016   22.1   6.9        1.1    9.9   0.0    8.0 10  Ldl_recept_b    Low-density lipoprotein receptor repeat class
  ------ inclusion threshold ------
       0.52    9.5   2.6         18    4.5   0.0    4.4  8  SdiA-regulated  SdiA-regulated


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.021        55       1      19 [.      49      67 ..      49      72 .. 0.88
   2 ?    4.2   0.0     0.019        48       3      19 ..     104     120 ..     103     124 .. 0.84
   3 !   33.1   0.0   1.4e-11   3.5e-08       1      26 [.     155     180 ..     155     182 .. 0.95
   4 !   17.7   0.0   1.1e-06    0.0027       1      25 [.     211     235 ..     211     238 .. 0.87
   5 !   19.6   0.0   2.5e-07   0.00064       1      26 [.     267     292 ..     267     294 .. 0.94
   6 !   29.2   0.0   2.3e-10   5.9e-07       1      26 [.     323     348 ..     323     350 .. 0.95
   7 !   26.4   0.0   1.8e-09   4.6e-06       1      27 [.     381     407 ..     381     408 .. 0.93
   8 !   18.2   0.1   7.2e-07    0.0018       1      27 [.     437     463 ..     437     464 .. 0.94
   9 ?   -2.4   0.0       2.4   6.2e+03       1      12 [.     493     504 ..     493     518 .. 0.79
  10 !    6.2   0.0    0.0046        12       1      26 [.     551     576 ..     551     578 .. 0.86
  11 !   13.0   0.0   3.1e-05     0.079       1      20 [.     591     610 ..     591     615 .. 0.95
  12 !   15.1   0.0   6.7e-06     0.017       3      19 ..     633     649 ..     631     654 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.021
                BSSEEEEEEETTTEEEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaD 19
                ++ P++va    G++y+aD
  EFC36497.1 49 LYTPNSVAFGLKGELYIAD 67
                57899************** PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.019
                 SEEEEEEETTTEEEEEE CS
         NHL   3 yPhGvavdsnGdiyVaD 19 
                 +P+G++v + G+i+  D
  EFC36497.1 104 NPTGIVVGTRGEILFVD 120
                 8***********98555 PP

  == domain 3  score: 33.1 bits;  conditional E-value: 1.4e-11
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P+G+a++s+G+iy+aD++nhr++
  EFC36497.1 155 LNSPRGIAISSTGEIYIADTYNHRIR 180
                 799**********************8 PP

  == domain 4  score: 17.7 bits;  conditional E-value: 1.1e-06
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 +nyP G+a++s+G+iy+aD+ n r+
  EFC36497.1 211 LNYPMGIAISSTGEIYIADTFNERI 235
                 79*****************766666 PP

  == domain 5  score: 19.6 bits;  conditional E-value: 2.5e-07
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n P+G+a++s+G+iy aD+ n+r++
  EFC36497.1 267 LNTPRGIAISSTGEIYFADTSNQRIR 292
                 789*********************98 PP

  == domain 6  score: 29.2 bits;  conditional E-value: 2.3e-10
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P+G+a++s+G+iy+aD++n+r++
  EFC36497.1 323 LNSPRGIAISSTGEIYIADTYNQRIR 348
                 799*********************98 PP

  == domain 7  score: 26.4 bits;  conditional E-value: 1.8e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n P +va +snG+iy+aD++nhr+++
  EFC36497.1 381 LNTPLSVACSSNGEIYIADTYNHRIRK 407
                 68899********************97 PP

  == domain 8  score: 18.2 bits;  conditional E-value: 7.2e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P++++v+snG iy +D+ n+r+++
  EFC36497.1 437 LSSPADIVVNSNGVIYFSDYDNNRIRK 463
                 679**********************97 PP

  == domain 9  score: -2.4 bits;  conditional E-value: 2.4
                 BSSEEEEEEETT CS
         NHL   1 fnyPhGvavdsn 12 
                 +n+P G++ +sn
  EFC36497.1 493 LNRPYGITFNSN 504
                 78999***9987 PP

  == domain 10  score: 6.2 bits;  conditional E-value: 0.0046
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n P+ ++++sn++i+ +Ds + rv 
  EFC36497.1 551 LNAPSKIVINSNNEIIFSDSLHGRVL 576
                 577*************9999888886 PP

  == domain 11  score: 13.0 bits;  conditional E-value: 3.1e-05
                 BSSEEEEEEETTTEEEEEEC CS
         NHL   1 fnyPhGvavdsnGdiyVaDs 20 
                 f++P G+a+ s+G+ y+aD+
  EFC36497.1 591 FRMPIGIAIGSDGEMYIADT 610
                 89*****************7 PP

  == domain 12  score: 15.1 bits;  conditional E-value: 6.7e-06
                 SEEEEEEETTTEEEEEE CS
         NHL   3 yPhGvavdsnGdiyVaD 19 
                 +P+G+++ds G+iyV+D
  EFC36497.1 633 SPRGITLDSKGNIYVTD 649
                 7**************** PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.8   0.0   6.6e-10   1.7e-06      29     218 ..      92     301 ..      80     313 .. 0.83
   2 !   15.6   0.0   3.6e-06    0.0091       8     115 ..     331     468 ..     325     534 .. 0.73
   3 !   18.4   0.1   5.1e-07    0.0013       9     200 ..     446     648 ..     441     661 .. 0.73

  Alignments for each domain:
  == domain 1  score: 27.8 bits;  conditional E-value: 6.6e-10
         SGL  29 patgketvldtpesvGaiaprkdgrlvvasksglalldlasgeletladeee..........dekpllrfNDgvvdpdGrlwfGtmgdeeakgeev.ga 116
                  ++g +t ++++++ G+++  ++g++++  +++++ ++  +g ++t+a   +           + +l+++  +++++ G++++ +  +++ +     g+
  EFC36497.1  92 GDGGLSTLAKVQNPTGIVVG-TRGEILFVDSDRIRKIE--NGIITTIAGTGDsrfggdgdlaTKAQLNSPRGIAISSTGEIYIADTYNHRIRRIALnGT 187
                 56788888999999999999.99999999999999886..79999999995566777787776668999999*************99999988876866 PP

         SGL 117 lyrldpdgk.......lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAv 201
                 +  + + g           ++ +l+ p G+a+s+ g+ +Y+aD+ +++i ++ ++ + +++    v+ + ++ +       ++p G+a+ ++G+++ A 
  EFC36497.1 188 INTVAGTGDsrfggdgDLATKAQLNYPMGIAISSTGE-IYIADTFNERIRRIALNGTINTIAGTGVLgLSGDGDLatkaqlNTPRGIAISSTGEIYFAD 285
                 66665553334555554556789**********9886.799************************995555555599999988**************** PP

         SGL 202 wgggkvvrfdpdGklie 218
                  ++++++r++ +G + +
  EFC36497.1 286 TSNQRIRRIALNGII-D 301
                 ***********9954.3 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 3.6e-06
         SGL   8 deeegaLlwvDilgqrihrldpatgketv...................ldtpesvGaiaprkdgrlvvasksglall..dlasgeletladeee..... 80 
                 +  +g+++  D ++qri r+ ++t+ +t+                   + ++ ++++++   +g++++a +++ ++    l++ +++t+a   +     
  EFC36497.1 331 ISSTGEIYIADTYNQRIRRIALNTNISTFagsgfgysgyvgdgglstdALLNTPLSVACS-SNGEIYIADTYNHRIRkiSLNN-TITTIAGTGDsgfsg 427
                 456899********************************9999995555444448888888.88******99999998544444.899999885566778 PP

         SGL  81 ......dekpllrfNDgvvdpdGrlwfGtmgdeeakgeev.g 115
                       +  +l ++ D+vv ++G ++f + ++++ ++    g
  EFC36497.1 428 dgglaiNA-RLSSPADIVVNSNGVIYFSDYDNNRIRKIASnG 468
                 88888555.9********************999988876653 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 5.1e-07
         SGL   9 eeegaLlwvDilgqrihrldpatgketv.................ldtpesvGaiaprkdgrlvvasksgl.............all..dlasgeletl 75 
                 + +g ++++D  ++ri ++ +++  +tv                 ++++ + G++++  + ++++ ++ g              +    d+asg  + +
  EFC36497.1 446 NSNGVIYFSDYDNNRIRKIASNGIITTVvgsgvigsggdgglainAQLNRPYGITFN-SNAEMYIVERMGSrirkvgvngiittV-AgsDIASGGTTSV 542
                 567889999999999999999999999999999999999999988888889999999.889999999999933333333332210.1223444433333 PP

         SGL  76 adeeedekpllrfNDgvvdpdGrlwfGtmgdeeakgeevgalyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrr 174
                  +    ++ l+ +  +v+ ++++++f        ++   g ++++  dg ++ v +++ +p G+a+ +dg+ +Y+aD+  + i ++d    +g      
  EFC36497.1 543 GSLA-TKTVLNAPSKIVINSNNEIIF--------SDSLHGRVLKIGLDGIISGVGNSFRMPIGIAIGSDGE-MYIADTSIFAILKIDK---KG------ 622
                 3333.222444444455555554444........4444599****************************95.9**********99876...34...... PP

         SGL 175 vfadlkkgegepDGlavDaeGnvwvA 200
                 v+ ++ +g + p G+++D++Gn++v+
  EFC36497.1 623 VLSTIVTGLESPRGITLDSKGNIYVT 648
                 4555666777799***********98 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.056   1.4e+02      50      72 ..      99     121 ..      81     127 .. 0.84
   2 !    6.6   0.0    0.0034       8.7      51      79 ..     153     180 ..     146     185 .. 0.85
   3 ?    4.0   0.0     0.022        56      52      79 ..     210     236 ..     202     241 .. 0.84
   4 ?    1.1   0.0      0.18   4.7e+02      51      78 ..     265     291 ..     248     296 .. 0.81
   5 !    5.6   0.0    0.0072        19      51      80 ..     321     349 ..     314     355 .. 0.83
   6 ?   -3.1   0.0       3.6   9.2e+03      67      78 ..     394     405 ..     388     408 .. 0.83
   7 ?   -1.9   0.0       1.5   3.9e+03      34      47 ..     446     459 ..     433     472 .. 0.59
   8 ?    0.4   0.0      0.31   7.8e+02      49      73 ..     587     610 ..     583     621 .. 0.77
   9 !    7.7   0.0    0.0016       4.1      46      73 ..     624     650 ..     620     657 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.056
  Arylesterase  50 asglssanGInidadkkyiyvad 72 
                    ++++ ++GI++ +   +++v +
    EFC36497.1  99 LAKVQNPTGIVVGTRGEILFVDS 121
                   578999**************965 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0034
  Arylesterase  51 sglssanGInidadkkyiyvadilresih 79 
                   ++l+s+ GI i++    iy+ad  ++ i 
    EFC36497.1 153 AQLNSPRGIAISSTGE-IYIADTYNHRIR 180
                   4689********9875.8*******9996 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.022
  Arylesterase  52 glssanGInidadkkyiyvadilresih 79 
                   +l+ + GI i++    iy+ad  +e i 
    EFC36497.1 210 QLNYPMGIAISSTGE-IYIADTFNERIR 236
                   68899******9875.8*****999985 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.18
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   ++l+++ GI i++    iy ad  ++ i
    EFC36497.1 265 AQLNTPRGIAISSTGE-IYFADTSNQRI 291
                   56899*******9876.78888877766 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.0072
  Arylesterase  51 sglssanGInidadkkyiyvadilresihv 80 
                   ++l+s+ GI i++    iy+ad  ++ i +
    EFC36497.1 321 AQLNSPRGIAISSTGE-IYIADTYNQRIRR 349
                   4689********9875.8****99999866 PP

  == domain 6  score: -3.1 bits;  conditional E-value: 3.6
  Arylesterase  67 yiyvadilresi 78 
                    iy+ad  ++ i
    EFC36497.1 394 EIYIADTYNHRI 405
                   59****999988 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 1.5
  Arylesterase  34 awtavvYyspsevk 47 
                      +v+Y+s  +++
    EFC36497.1 446 NSNGVIYFSDYDNN 459
                   44566676655544 PP

  == domain 8  score: 0.4 bits;  conditional E-value: 0.31
  Arylesterase  49 vasglssanGInidadkkyiyvadi 73 
                   v +++ ++ GI i +d   +y+ad 
    EFC36497.1 587 VGNSFRMPIGIAIGSDGE-MYIADT 610
                   567999********9986.699985 PP

  == domain 9  score: 7.7 bits;  conditional E-value: 0.0016
  Arylesterase  46 vkvvasglssanGInidadkkyiyvadi 73 
                   +++ + gl+s+ GI++d++   iyv+d+
    EFC36497.1 624 LSTIVTGLESPRGITLDSKG-NIYVTDL 650
                   567899***********987.58***97 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.4       2.6   6.6e+03      12      20 ..      24      32 ..      22      32 .. 0.83
   2 !    5.3   0.1    0.0076        20      14      29 ..     157     172 ..     138     172 .. 0.88
   3 ?    2.7   0.0      0.05   1.3e+02      14      29 ..     213     228 ..     198     228 .. 0.85
   4 ?    2.9   0.1     0.042   1.1e+02      14      27 ..     269     282 ..     254     288 .. 0.85
   5 !    5.2   0.0     0.008        21      14      29 ..     325     340 ..     311     340 .. 0.88
   6 ?   -2.3   0.0       1.8   4.6e+03      18      29 ..     387     398 ..     383     398 .. 0.77
   7 !   16.9   0.0   1.8e-06    0.0047      15      29 ..     634     648 ..     630     648 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.6
        SBBP 12 stygngIav 20
                +t++++I++
  EFC36497.1 24 QTTTYNITT 32
                799999996 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0076
        SBBP  14 ygngIavDsnGNiYvt 29 
                 +++gIa+ s G iY++
  EFC36497.1 157 SPRGIAISSTGEIYIA 172
                 79************97 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.05
        SBBP  14 ygngIavDsnGNiYvt 29 
                 y+ gIa+ s G iY++
  EFC36497.1 213 YPMGIAISSTGEIYIA 228
                 788***********97 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.042
        SBBP  14 ygngIavDsnGNiY 27 
                 +++gIa+ s G iY
  EFC36497.1 269 TPRGIAISSTGEIY 282
                 79*********999 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.008
        SBBP  14 ygngIavDsnGNiYvt 29 
                 +++gIa+ s G iY++
  EFC36497.1 325 SPRGIAISSTGEIYIA 340
                 79************97 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 1.8
        SBBP  18 IavDsnGNiYvt 29 
                 +a  snG iY++
  EFC36497.1 387 VACSSNGEIYIA 398
                 666789999996 PP

  == domain 7  score: 16.9 bits;  conditional E-value: 1.8e-06
        SBBP  15 gngIavDsnGNiYvt 29 
                 ++gI+ Ds GNiYvt
  EFC36497.1 634 PRGITLDSKGNIYVT 648
                 9*************9 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0   0.00037      0.95      70     102 ..     158     190 ..      60     199 .. 0.83
   2 !    4.7   0.0    0.0093        24      72     100 ..     216     244 ..     202     248 .. 0.94
   3 ?    3.0   0.0     0.033        83      71      97 ..     327     353 ..     246     359 .. 0.71
   4 ?    1.9   0.0     0.068   1.7e+02      73     100 ..     387     414 ..     385     423 .. 0.87
   5 ?   -0.4   0.0      0.34   8.7e+02      69     101 ..     439     471 ..     399     476 .. 0.72
   6 ?   -1.2   0.0      0.59   1.5e+03      72     101 ..     596     625 ..     594     648 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00037
  Phytase-like  70 pEgiavapdgtfwvssEggpfilefdadGkllr 102
                   p gia++++g++++++ ++++i+++ ++G++ +
    EFC36497.1 158 PRGIAISSTGEIYIADTYNHRIRRIALNGTINT 190
                   569**************************9865 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0093
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkl 100
                   gia++++g++++++ ++ +i+++ ++G++
    EFC36497.1 216 GIAISSTGEIYIADTFNERIRRIALNGTI 244
                   89*************************97 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.033
  Phytase-like  71 EgiavapdgtfwvssEggpfilefdad 97 
                    gia++++g++++++ ++ +i+++ ++
    EFC36497.1 327 RGIAISSTGEIYIADTYNQRIRRIALN 353
                   478888888888888888888877665 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.068
  Phytase-like  73 iavapdgtfwvssEggpfilefdadGkl 100
                   +a +++g++++++ ++++i++++++ ++
    EFC36497.1 387 VACSSNGEIYIADTYNHRIRKISLNNTI 414
                   66789******************98665 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.34
  Phytase-like  69 DpEgiavapdgtfwvssEggpfilefdadGkll 101
                    p +i+v+++g +++s+  +++i+++  +G ++
    EFC36497.1 439 SPADIVVNSNGVIYFSDYDNNRIRKIASNGIIT 471
                   55579999*********999*****99999765 PP

  == domain 6  score: -1.2 bits;  conditional E-value: 0.59
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkll 101
                   gia+ +dg++++++    +il++d++G l 
    EFC36497.1 596 GIAIGSDGEMYIADTSIFAILKIDKKGVLS 625
                   899999******************999884 PP

>> Ldl_recept_b  Low-density lipoprotein receptor repeat class B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.34   8.8e+02      32      40 ..     102     110 ..      90     110 .. 0.74
   2 ?    1.1   0.0      0.23   5.8e+02      30      40 ..     152     163 ..     144     163 .. 0.76
   3 ?   -2.1   0.0       2.3   5.8e+03       3      22 ..     169     187 ..     167     188 .. 0.83
   4 ?   -3.9   0.0         7   1.8e+04      10      22 ..     232     243 ..     225     246 .. 0.77
   5 ?    1.4   0.0      0.18   4.5e+02      31      40 ..     265     275 ..     254     275 .. 0.76
   6 !    9.9   0.0   0.00041       1.1       2      40 ..     280     331 ..     279     331 .. 0.85
   7 ?   -2.6   0.0       3.1   8.1e+03      31      40 ..     435     445 ..     425     445 .. 0.72
   8 ?   -2.3   0.0       2.5   6.5e+03       3      21 ..     451     468 ..     449     469 .. 0.74
   9 ?    1.0   0.1      0.24   6.1e+02       7      26 ..     560     578 ..     559     599 .. 0.73
  10 ?    1.2   0.0      0.21   5.4e+02      32      41 ..     631     640 ..     615     641 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.34
                   -S-EEEEEE CS
  Ldl_recept_b  32 lqnPrgiAv 40 
                   +qnP+gi+v
    EFC36497.1 102 VQNPTGIVV 110
                   8******98 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.23
                   SS.-S-EEEEEE CS
  Ldl_recept_b  30 ed.lqnPrgiAv 40 
                    + l+ PrgiA+
    EFC36497.1 152 KAqLNSPRGIAI 163
                   44699******8 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 2.3
                   EEEEETTTTEEEES-STTS- CS
  Ldl_recept_b   3 lYWtDwsldasisvadlnGs 22 
                   +Y  D  ++ +i +++lnG+
    EFC36497.1 169 IYIADTYNH-RIRRIALNGT 187
                   677788899.9*******96 PP

  == domain 4  score: -3.9 bits;  conditional E-value: 7
                   TTEEEES-STTS- CS
  Ldl_recept_b  10 ldasisvadlnGs 22 
                   ++ +i +++lnG+
    EFC36497.1 232 NE-RIRRIALNGT 243
                   66.7899999996 PP

  == domain 5  score: 1.4 bits;  conditional E-value: 0.18
                   S.-S-EEEEEE CS
  Ldl_recept_b  31 d.lqnPrgiAv 40 
                   + l++PrgiA+
    EFC36497.1 265 AqLNTPRGIAI 275
                   3699******8 PP

  == domain 6  score: 9.9 bits;  conditional E-value: 0.00041
                   EEEEEETTTTEEEES-STTS---EEEE.-SS..............-S-EEEEEE CS
  Ldl_recept_b   2 klYWtDwsldasisvadlnGshrktlf.qed..............lqnPrgiAv 40 
                    +Y+ D s++ +i +++lnG   +t++ ++d              l+ PrgiA+
    EFC36497.1 280 EIYFADTSNQ-RIRRIALNGII-DTIAgTGDprfggdgdlatkaqLNSPRGIAI 331
                   69********.*********98.7777466688888888999999999999987 PP

  == domain 7  score: -2.6 bits;  conditional E-value: 3.1
                   S.-S-EEEEEE CS
  Ldl_recept_b  31 d.lqnPrgiAv 40 
                   + l+ P++i+v
    EFC36497.1 435 ArLSSPADIVV 445
                   36999****98 PP

  == domain 8  score: -2.3 bits;  conditional E-value: 2.5
                   EEEEETTTTEEEES-STTS CS
  Ldl_recept_b   3 lYWtDwsldasisvadlnG 21 
                   +Y++D  +  +i +++ nG
    EFC36497.1 451 IYFSDYDNN-RIRKIASNG 468
                   9****9888.776666655 PP

  == domain 9  score: 1.0 bits;  conditional E-value: 0.24
                   ETTTTEEEES-STTS---EE CS
  Ldl_recept_b   7 DwsldasisvadlnGshrkt 26 
                   +++++  i++++l+G   k+
    EFC36497.1 560 NSNNE-IIFSDSLHGRVLKI 578
                   68899.9********88776 PP

  == domain 10  score: 1.2 bits;  conditional E-value: 0.21
                   -S-EEEEEEE CS
  Ldl_recept_b  32 lqnPrgiAvD 41 
                   l  Prgi++D
    EFC36497.1 631 LESPRGITLD 640
                   789******9 PP

>> SdiA-regulated  SdiA-regulated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.62   1.6e+03     220     239 ..     153     172 ..     145     176 .. 0.83
   2 ?   -3.9   0.0       2.6   6.6e+03     224     238 ..     213     227 ..     207     229 .. 0.82
   3 ?   -3.1   0.0       1.4   3.7e+03     220     238 ..     265     283 ..     252     297 .. 0.73
   4 ?   -1.8   0.0      0.57   1.5e+03     220     239 ..     321     340 ..     314     352 .. 0.84
   5 ?   -4.2   0.0       3.1   7.9e+03      71      97 ..     387     413 ..     385     417 .. 0.75
   6 ?   -1.7   0.0      0.52   1.3e+03     218     239 ..     489     510 ..     483     512 .. 0.85
   7 ?    0.1   0.0      0.15   3.8e+02     203     239 ..     573     608 ..     547     613 .. 0.78
   8 ?    4.5   0.0    0.0069        18     221     238 ..     630     647 ..     614     649 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.62
  SdiA-regulated 220 edipqaEGvamDeegnlYiv 239
                      +++ + G+a+ + g++Yi 
      EFC36497.1 153 AQLNSPRGIAISSTGEIYIA 172
                     5677899***********95 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 2.6
  SdiA-regulated 224 qaEGvamDeegnlYi 238
                      + G+a+ + g++Yi
      EFC36497.1 213 YPMGIAISSTGEIYI 227
                     5679**********9 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.4
  SdiA-regulated 220 edipqaEGvamDeegnlYi 238
                      +++ + G+a+ + g++Y 
      EFC36497.1 265 AQLNTPRGIAISSTGEIYF 283
                     4556777888888888886 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 0.57
  SdiA-regulated 220 edipqaEGvamDeegnlYiv 239
                      +++ + G+a+ + g++Yi 
      EFC36497.1 321 AQLNSPRGIAISSTGEIYIA 340
                     56678899**********96 PP

  == domain 5  score: -4.2 bits;  conditional E-value: 3.1
  SdiA-regulated  71 veylgdgrlaivdEreqalvvvkvdad 97 
                     v+  ++g++ i+d  ++++ +++++++
      EFC36497.1 387 VACSSNGEIYIADTYNHRIRKISLNNT 413
                     677788888888888888888888765 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 0.52
  SdiA-regulated 218 LeedipqaEGvamDeegnlYiv 239
                     ++ +++++ G++++++ ++Yiv
      EFC36497.1 489 INAQLNRPYGITFNSNAEMYIV 510
                     567889999************9 PP

  == domain 7  score: 0.1 bits;  conditional E-value: 0.15
  SdiA-regulated 203 gevlsslsLlkgsngLeedipqaEGvamDeegnlYiv 239
                     g+vl  + L +  +g+ ++ + + G+a+ ++g++Yi 
      EFC36497.1 573 GRVL-KIGLDGIISGVGNSFRMPIGIAIGSDGEMYIA 608
                     4543.3568888899999999**************95 PP

  == domain 8  score: 4.5 bits;  conditional E-value: 0.0069
  SdiA-regulated 221 dipqaEGvamDeegnlYi 238
                      ++ + G+++D++gn+Y+
      EFC36497.1 630 GLESPRGITLDSKGNIYV 647
                     567789***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (747 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       421  (0.0234815); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.70u 0.37s 00:00:01.06 Elapsed: 00:00:00.55
# Mc/sec: 4121.82
//
Query:       EFC36498.1  [L=447]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (447 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       629  (0.0350828); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 2939.98
//
Query:       EFC36499.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.03   14.2   1.4      0.051   13.5   0.1    2.1  2  F-box     F-box domain
       0.58   10.2  10.1          1    9.4  10.1    1.3  1  SpoIIM    Stage II sporulation protein M


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   5.7e-06     0.051       3      30 ..      18      45 ..      16      50 .. 0.91
   2 ?   -3.4   0.1       1.1   9.9e+03      25      32 ..     250     257 ..     249     258 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.7e-06
                HHHS-HHHHHHHHHTS-HHHHHHHCTT- CS
       F-box  3 lsrLPsevlrhILerLplsdllalrrVS 30
                l  L+s+ +++I ++L+++d++++++V 
  EFC36499.1 18 LMKLSSDNWLEICRYLNPCDVFRISQVN 45
                678***********************95 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.1
                 HHCTT-HH CS
       F-box  25 alrrVSkg 32 
                 + r+VS+ 
  EFC36499.1 250 STRLVSRQ 257
                 6799**97 PP

>> SpoIIM  Stage II sporulation protein M
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4  10.1   0.00012         1       9     102 ..     333     425 ..     327     430 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00012
      SpoIIM   9 illgallaasnfaeqisseskensalslflaifan.NlrvalllfllGllllgiptilvllinGfvlGavaalvaef..gglllflllilPhgilel 102
                 ++l +++ + + +    + s+ ++  s  +++f+n  + ++l++ +lG + + ++t+++ +  +++lG v  +v ++  +g+ l++l+il   +l+ 
  EFC36499.1 333 AILTYIYCNYKVF----GFSSFYHTYSQYTNLFTNtMADYSLFMKVLGCMGMTLFTLFFSFCVAASLGGVVHFVGKYtdHGFALYWLFILSNIVLYF 425
                 4445555551111....33444445556788899977788999*****9999****************9989999999988*********9888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       809  (0.0451224); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 3151.12
//
Query:       EFC36500.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       837  (0.0466841); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1528.45
//
Query:       EFC36501.1  [L=819]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.1e-25   86.8   4.6    1.7e-24   85.4   4.6    1.9  1  Synaptobrevin  Synaptobrevin
      3e-09   36.8   0.0    9.5e-09   35.2   0.0    1.8  1  Longin         Regulated-SNARE-like domain
     0.0037   17.5   2.2        2.5    8.4   0.0    3.6  3  Herpes_UL14    Herpesvirus UL14-like protein
  ------ inclusion threshold ------
      0.032   13.2   0.9      0.055   12.4   0.9    1.4  1  Pex24p         Integral peroxisomal membrane peroxin
      0.057   13.3   9.0      0.028   14.3   4.5    2.3  2  RIFIN          Rifin
       0.18   12.2  11.1        3.5    8.0   0.6    3.3  3  DUF5383        Family of unknown function (DUF5383)
       0.34   10.8   4.1       0.42   10.5   0.3    2.8  3  GP41           Retroviral envelope protein
        4.7    7.3   9.2        7.6    6.6   0.6    3.2  3  DUF848         Gammaherpesvirus protein of unknown function (


Domain annotation for each model (and alignments):
>> Synaptobrevin  Synaptobrevin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.4   4.6   7.8e-28   1.7e-24       2      89 .]     116     203 ..     115     203 .. 0.96

  Alignments for each domain:
  == domain 1  score: 85.4 bits;  conditional E-value: 7.8e-28
                    XXHHHHHHHHHHCCCCHHCCHHHHCHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHTXXXXXXXXXXXXXXXXXXXXXXXX CS
  Synaptobrevin   2 ndklakikaevdevkdimkeNidkvlergekldeLvdktenLqssaqqFkkqarklkrkmwwknmkliiililvvlililiiiivicg 89 
                    +dk+++++++++ vk+ m eNidkvlergek ++L +k++++  +a++Fk+ + klk+km w+ + +i+i+i++++++i+i i++ cg
     EFC36501.1 116 ADKITALQDKLETVKESMVENIDKVLERGEKFETLYEKSDEMLVEANEFKRGTVKLKNKMIWRLIVIIVIIIIILIVIIIIAILAGCG 203
                    69***************************************************************99999999999999999998885 PP

>> Longin  Regulated-SNARE-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2   0.0   4.2e-12   9.5e-09       2      68 ..      31      97 ..      30     109 .. 0.91

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 4.2e-12
      Longin  2 klilkkishsspqkltythdsytfhylaedgltylviadesyprrlaFafLeeikreFlakygtakt 68
                ++i++k+s+++ +k t+t d++ +hy  +++++y ++a+++ ++r+  af++e++  F ++ +++++
  EFC36501.1 31 EKIVRKVSKDTLEKRTLTSDELEIHYKKSGEYIYFCVASNDTKKRVCWAFIDEVEGAFSQSNNKRQA 97
                5799****9999******999**************************************99986554 PP

>> Herpes_UL14  Herpesvirus UL14-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.3     0.012        27      78     122 ..      90     138 ..      79     160 .. 0.72
   2 !    8.4   0.0    0.0011       2.5      18      83 ..     217     286 ..     207     316 .. 0.72
   3 ?    0.7   0.0      0.25   5.5e+02      81     122 ..     759     802 ..     749     811 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.012
  Herpes_UL14  78 qaelrsiLkanRrylspkllerldatedkllekedsLeeavael....n 122
                  q + +    +nR+ +++k+ +  d ++dk++  +d+Le   + +    +
   EFC36501.1  90 QSNNKRQASGNRKIIKAKIDKWNDPNADKITALQDKLETVKESMveniD 138
                  6667777899********************9999999987766543222 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0011
  Herpes_UL14  18 ykertLellseGvstqdPaFveaFtaAkeaeedlkaqlrsd...aRle.svrrkikriqakveeqaelrs 83 
                  y  + L l+se  +  +  F + F aAk  +e+ ka  +++    ++e  +++ki + ++ v + ++ ++
   EFC36501.1 217 YCSSKLGLISEQRNNYHTTFCNLFHAAKPSHEEHKALQQVKsleSKFEeLLQKKISNEKSTVTNNLDAQN 286
                  777889999************************9986555311133431356677777777777666554 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.25
  Herpes_UL14  81 lrsiLkanRryl..spkllerldatedkllekedsLeeavaeln 122
                  + +i k nR  l  +p++ + +d t+++l ek  +L  +v +l 
   EFC36501.1 759 MVKIKKNNRNILesDPGIRRFFDDTQNALEEKVAKLGISVPKLK 802
                  556778889998434789999***********999987776665 PP

>> Pex24p  Integral peroxisomal membrane peroxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.9   2.5e-05     0.055     111     251 ..     137     280 ..      52     323 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.5e-05
      Pex24p 111 skeivlnLrdlqnkmedllnpidalekflkelagfkdenlstllfltllltpililllsrlipw...rlillvlgailltyHpsvkkvllrllwrlkiv 206
                   ++++  +++ +  e   + + ++++f+  ++++k++++ +l+++++++++ili++++  i       ++  +g+++  y +s    + +   r  + 
  EFC36501.1 137 IDKVLERGEKFETLYEKSDEMLVEANEFKRGTVKLKNKMIWRLIVIIVIIIIILIVIIIIAILAgcgFPTFERCGVFVNNYCSSKLGLISE--QRNNYH 233
                 3344444457777777778888888889999999***********9999999999998555544244455666677777777777777777..788888 PP

      Pex24p 207 rlvvkyltgkelkka..kskekkeelikelekketadiildespetr 251
                  +++++  + + + +  k+ +++++l++++e+  +++i+ ++s+ t+
  EFC36501.1 234 TTFCNLFHAAKPSHEehKALQQVKSLESKFEELLQKKISNEKSTVTN 280
                 88888887777665566888888888888888888888777766665 PP

>> RIFIN  Rifin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   4.5   1.2e-05     0.028     205     301 ..      91     199 ..      26     200 .. 0.58
   2 ?    0.4   0.1      0.21   4.7e+02     216     266 ..     237     287 ..     208     325 .. 0.48

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.2e-05
       RIFIN 205 l.........klkkskaaltsakekekkeasskekikkkvekivekaekkaaaaaaeaaaeataeaekaetaaveattaslqtaii...asivaivvIv 291
                 +          +  ++++ +++  + +k +  ++k ++ +e++ve++ k  ++ ++ ++  ++++    e+++++  t +l++++i   + i++i++I+
  EFC36501.1  91 SnnkrqasgnRKIIKAKIDKWNDPNADKITALQDKLETVKESMVENIDKVLERGEKFETLYEKSDEMLVEANEFKRGTVKLKNKMIwrlIVIIVIIIII 189
                 133344333333333444456666666777777777777777777777777666664444444444444555566666666666651114555566666 PP

       RIFIN 292 LimvIIYLiL 301
                 Li++II  iL
  EFC36501.1 190 LIVIIIIAIL 199
                 6666666665 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.21
       RIFIN 216 sakekekkeasskekikkkvekivekaekkaaaaaaeaaaeataeaekaet 266
                 ++  +  k +++++k+ ++v+++ +k+e+  +++ +++++++t+++ ++++
  EFC36501.1 237 CNLFHAAKPSHEEHKALQQVKSLESKFEELLQKKISNEKSTVTNNLDAQNL 287
                 222222333333333444444444444444444444444444444444333 PP

>> DUF5383  Family of unknown function (DUF5383)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.6    0.0015       3.5      94     118 ..     171     195 ..     110     199 .. 0.72
   2 ?    7.9   2.9    0.0017       3.8      31     104 ..     247     320 ..     225     328 .. 0.69
   3 ?   -3.7   0.0       6.7   1.5e+04      29      39 ..     485     495 ..     481     498 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0015
     DUF5383  94 ksnlLpillillivllivvllivli 118
                   n++ + li++iv++i++l++++i
  EFC36501.1 171 LKNKMIWRLIVIIVIIIIILIVIII 195
                 4577788888888888888876665 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0017
     DUF5383  31 peeqkdLtFtkkekeeaeelkesLfassekesntiaakakelgLfseekesvkq...sateqeseeksnlLpillil 104
                  ee k L+  k+ + + eel ++   + ++e+ t++++ +  +L  + ++++ +   + ++++++++  +L+i++ l
  EFC36501.1 247 HEEHKALQQVKSLESKFEELLQK---KISNEKSTVTNNLDAQNLVLSTNNLYDLvleHWDDESKSSSEEELTIIYKL 320
                 58999998888888888887764...44445556666555555555555555441104455555889999****965 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 6.7
     DUF5383  29 eipeeqkdLtF 39 
                 +  ee kd+tF
  EFC36501.1 485 SWKEEMKDFTF 495
                 5689******9 PP

>> GP41  Retroviral envelope protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.3   0.00019      0.42     122     170 ..     153     205 ..     100     230 .. 0.65
   2 ?   -2.6   0.3         2   4.4e+03     100     113 ..     266     282 ..     231     325 .. 0.56
   3 ?    0.2   0.0      0.27   6.1e+02      18      61 ..     761     804 ..     752     810 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00019
                 HHHHHHHHHHHHH.HHHHHHHHHH...HHHH.HHHHHCHHHHHHHHHHHX.....X CS
        GP41 122 ktldeldkldklaqslanwfkllnsl.Wvky.ivvilvglrivlivlsll.....P 170
                 k  + l + ++++      +kl n + W+   i+vi++ ++iv+i++ +l     P
  EFC36501.1 153 KSDEMLVEANEFK---RGTVKLKNKMiWRLIvIIVIIIIILIVIIIIAILagcgfP 205
                 4444445555555...4456677766688754556666666666666665444443 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2
                 H...HHHHHHHHHHHHH CS
        GP41 100 t...evsydlaelhnli 113
                     ++s++ + ++n++
  EFC36501.1 266 LlqkKISNEKSTVTNNL 282
                 22223333333333332 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.27
                 HHHHHHHHHHHHHHHHHHHHHHHHHCHHHH..........HHHH CS
        GP41  18 glqrnvlkvleeqqeldkkleaRlsAleevvrvlgedvaslktr 61 
                  +++n  ++le+   + + +++  +Alee v +lg  v +lk  
  EFC36501.1 761 KIKKNNRNILESDPGIRRFFDDTQNALEEKVAKLGISVPKLKPT 804
                 466777777777888888899999**************999865 PP

>> DUF848  Gammaherpesvirus protein of unknown function (DUF848)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.6    0.0034       7.6      76     119 ..     105     148 ..      85     161 .. 0.83
   2 ?    4.8   0.6     0.013        29      32      99 ..     233     300 ..     230     308 .. 0.77
   3 ?   -3.4   0.1       4.2   9.3e+03      66      88 ..     749     771 ..     744     792 .. 0.64

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0034
      DUF848  76 lslLkklnrkkvarveeLtdkvlelkeevsleldsleeaqeeyq 119
                  +++ k n ++ +++ +L+dk + +ke +  ++d++ e +e+ +
  EFC36501.1 105 KAKIDKWNDPNADKITALQDKLETVKESMVENIDKVLERGEKFE 148
                 4567889999**************************99999866 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.013
      DUF848  32 salFekQfddarkalrsleqlkrtkeikalvea.vdteieakkkelslLkklnrkk.varveeLtdkvle 99 
                 ++ F + f+ a+ + +++++l++ k+++++ e  ++++i ++k  +    +l+ ++ v   ++L d vle
  EFC36501.1 233 HTTFCNLFHAAKPSHEEHKALQQVKSLESKFEElLQKKISNEKSTVTN--NLDAQNlVLSTNNLYDLVLE 300
                 567888999********************9975278899998887776..56655414567777777777 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 4.2
      DUF848  66 dteieakkkelslLkklnrkkva 88 
                 ++e+e  kke+ ++kk nr+ ++
  EFC36501.1 749 KEELEWCKKEMVKIKKNNRNILE 771
                 55666666777776666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (819 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2141  (0.119415); expected 358.6 (0.02)
Passed bias filter:                      908  (0.0506442); expected 358.6 (0.02)
Passed Vit filter:                       113  (0.00630264); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.01u 0.36s 00:00:01.37 Elapsed: 00:00:00.56
# Mc/sec: 4370.14
//
Query:       EFC36502.1  [L=842]
Description: 3',5'-cyclic-nucleotide phosphodiesterase regA [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.4e-83  279.0   1.4    3.4e-83  279.0   1.4    2.8  3  PDEase_I      3'5'-cyclic nucleotide phosphodiesterase
    5.7e-30  103.8   2.4    2.4e-28   98.5   0.2    3.1  3  Response_reg  Response regulator receiver domain
     0.0031   17.5  15.3     0.0031   17.5  15.3    2.0  2  Mucin         Mucin-like glycoprotein
     0.0079   16.6   0.1      0.045   14.1   0.1    2.4  2  FleQ          Flagellar regulatory protein FleQ
  ------ inclusion threshold ------
      0.032   14.5   0.1      0.094   12.9   0.1    1.8  1  HD            HD domain
      0.038   14.1   2.3        8.6    6.6   0.3    2.9  2  PYRIN         PAAD/DAPIN/Pyrin domain
        1.3    8.2   8.3       0.58    9.4   3.9    2.2  2  DUF3450       Protein of unknown function (DUF3450)
        1.7    9.3   9.2        2.9    8.6   0.9    2.4  2  Pex14_N       Peroxisomal membrane anchor protein (Pex14p) co


Domain annotation for each model (and alignments):
>> PDEase_I  3'5'-cyclic nucleotide phosphodiesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   1.6      0.08   1.8e+02     101     201 ..     247     344 ..     218     381 .. 0.62
   2 !  279.0   1.4   1.5e-86   3.4e-83       1     230 [.     443     667 ..     443     674 .. 0.95
   3 ?   -2.2   0.6       1.3   2.8e+03      88     134 ..     712     760 ..     698     794 .. 0.64

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.08
                 HHHHHHHHHHHTTSGGGHHHHHHHHHHHCCTTS-TTTCT..-HHHHHHHHHHHHHHHHTGCCCS-HHHHHHHHHHHHHHHHHHHHHHHHCT----GGGT CS
    PDEase_I 101 elrkliielIlaTdmakhfelleklkelvkkkeknslnke.eeedkklllsllikaaDisnptkpweiskkwaelvleEffeqgdeekelglpvsplmd 198
                 e+++ i++ +  T m+  ++ +++l  ++ k++ ++++ +  +  ++l  + l k    sn  ++ e+ ++  + +++Ef ++gd+  + + + +p+ +
  EFC36502.1 247 EIKNQINNTV-ETPMQVVMKTIADL--MEGKYSIENSKGAlIAVLRSLGSKDLYKP-AFSNLLRKGELDDNTRRWLQTEFMNEGDNNVNGNKSNTPISN 341
                 4444444443.56666666666666..22222222222212222222222333333.3799999999******************99876666666666 PP

                 SSC CS
    PDEase_I 199 rek 201
                 +++
  EFC36502.1 342 ESS 344
                 655 PP

  == domain 2  score: 279.0 bits;  conditional E-value: 1.5e-86
                 SSSHHHHHHHHHHHHHHHHCCHCCCCS-HHHHHHHHHHHHHTTTT--S--HHHHHHCT-HHHHHCCCSSHHHHHHHHHHHHHHTSGGG-TTTTS-HHHH CS
    PDEase_I   1 YHNfrHAadVlqalfyllkkeklkeeltpleilalliaalcHDvdHpGtnNsFlvnskselailYndesvLEnhHlalafqllkkeecnifknlskeey 99 
                 YHNf+HA+dV+q+ ++ll   ++++ ++p+e++al+++a++HDv+HpG+nN++l+n k ela +Ynd svLEnhH+++af ll k+  ni +nlsk+e+
  EFC36502.1 443 YHNFTHAVDVTQFAYHLLLVDRISQMFSPMEKFALMFSAIMHDVGHPGVNNNYLINIKDELALIYNDVSVLENHHASQAFYLLLKH--NICSNLSKDEF 539
                 ************************99*********************************************************999..*********** PP

                 HHHHHHHHHHHHTTSGGGHHHHHHHHHHHCCTTS-TTTCT.-HHHHHHHHHHHHHHHHTGCCCS-HHHHHHHHHHHHHHHHHHHHHHHHCT----GGGT CS
    PDEase_I 100 kelrkliielIlaTdmakhfelleklkelvkkkeknslnkeeeedkklllsllikaaDisnptkpweiskkwaelvleEffeqgdeekelglpvsplmd 198
                 ke+r+l+i+ Il Tdm++hfe+l+k+++  ++ +    +ke++ed+ +l+ +++k++D+sn  +p+++s+kw++++leEff qgd e+ +glp+splmd
  EFC36502.1 540 KEFRRLVISTILCTDMSHHFEILTKFQTRLQTGTL---SKESKEDRLQLMGVILKCSDVSNALRPFDVSEKWSNVLLEEFFLQGDSERDRGLPISPLMD 635
                 **************************988886555...4445799999*************************************************** PP

                 SSC...HHHHHHHHHHTHHHHHHHHHHC-GGG CS
    PDEase_I 199 rektslaksqigFidfvvkplfealakllpel 230
                 r++ + +ksq++Fid+++ plf++l + +  l
  EFC36502.1 636 RRSVDKPKSQLNFIDYIAAPLFNNLITYCSCL 667
                 ***9999****************998777555 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 1.3
                 G-TTTTS-HHH..HHHHHHHHHHHHHTTSGGGHHHHHHHHHHHCCTTS- CS
    PDEase_I  88 cnifknlskee..ykelrkliielIlaTdmakhfelleklkelvkkkek 134
                 + i ++ ++++    ++ +  ++ +l   m  hf++ + +  l+  +e 
  EFC36502.1 712 NTITTTTTTKTstTTTTTNSQEKPVLTGSMPSHFAKAKGFTILIIDDES 760
                 2333333333333667778888889999999999988888665554444 PP

>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   98.5   0.2   1.1e-31   2.4e-28       1     111 [.      92     204 ..      92     205 .. 0.95
   2 ?   -1.3   0.0         1   2.3e+03      40      71 ..     371     402 ..     349     415 .. 0.71
   3 ?    3.4   0.1     0.037        84       1      53 [.     753     804 ..     753     810 .. 0.76

  Alignments for each domain:
  == domain 1  score: 98.5 bits;  conditional E-value: 1.1e-31
                   EEEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHHHHHH..ESEEEEESSCSSSEHHHHHHHHHHCT.TTSEEEEEESSTSHHHHHHHHHCTE CS
  Response_reg   1 vlivdDdplvrellrqlleeegyeevaeaedgkealellkeek..vdlillDinmpgmdGlellkeireed.pelpviiltahseeedavealkaga 94 
                   vl+vdDd+++r++l++lle+ g+ +v+++e gk+ale l+ee   ++l+l+D+ mp+mdGl+llk  r+   +++p+i++++ ++ ++++++++ ga
    EFC36502.1  92 VLVVDDDRVARQVLTKLLEQLGF-QVKAVEGGKQALEVLREEGnnYHLLLVDVLMPDMDGLQLLKIFRQAYsEDMPIIMVSSSEDPDTINQCFQSGA 187
                   8**********************.***************777667**********************9998799*********************** PP

                   SEEEESSG-HHHHHHHH CS
  Response_reg  95 ddflsKpfdpeeLlkal 111
                   +dfl+Kp++ e L+ ++
    EFC36502.1 188 EDFLQKPVQLEILKRRV 204
                   *********99998887 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1
                   HHHHESEEEEESSCSSSEHHHHHHHHHHCTTT CS
  Response_reg  40 keekvdlillDinmpgmdGlellkeireedpe 71 
                    +++vd i++   +pg  G +++++++  +++
    EFC36502.1 371 YHKQVDDIVTKNTLPGDLGSHTFDTLKYSHDQ 402
                   45568888888888888888888888766644 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.037
                   EEEESSSHHH.HHHHHHHHHHTTEEEEEEESSHHHHHHHHHHHHESEEEEESSC CS
  Response_reg   1 vlivdDdplv.rellrqlleeegyeevaeaedgkealellkeekvdlillDinm 53 
                   +li+dD+ ++ ++ l+q l +  y +v +++ +k   el+k++  d+ill+ ++
    EFC36502.1 753 ILIIDDESAQcAKKLEQPLLSLSY-TVVSTTLAKTESELVKSK-ADIILLNYDI 804
                   89****988725789999999***.777777666666666655.8999988765 PP

>> Mucin  Mucin-like glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   1.5       1.5   3.4e+03      35      62 ..     332     359 ..     319     383 .. 0.53
   2 !   17.5  15.3   1.4e-06    0.0031      61     142 ..     702     783 ..     656     784 .. 0.62

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.5
       Mucin  35 vveaaegqskltttttttkppttttttt 62 
                 + ++++  s+  ++tt  ++  t   ++
  EFC36502.1 332 GNKSNTPISNESSPTTEKNSQQTKEQSQ 359
                 3333333333333333333333332222 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 1.4e-06
       Mucin  61 tttasttittkttkattttttttttttateaPsdavttaeaPtttttrapsrlrevd.GslsssaWvcaPLllavsalaytav 142
                 + ++ tt+ttk t +ttttt+t+tttt+t++  + v t   P+     +  ++  +d  s   +     PLl +   ++ t++
  EFC36502.1 702 S-STHTTTTTKNTITTTTTTKTSTTTTTTNSQEKPVLTGSMPSHFAKAKGFTILIIDdESAQCAKKLEQPLLSLSYTVVSTTL 783
                 2.233344566666777777777777777777777788888877666666666666514666666778888888888887765 PP

>> FleQ  Flagellar regulatory protein FleQ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.1     2e-05     0.045       1      81 [.      91     176 ..      91     186 .. 0.68
   2 ?   -2.9   0.0       3.9   8.6e+03       2      12 ..     753     763 ..     752     795 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2e-05
        FleQ   1 kiLvidddaerrrdletiLeFlgeeveavsseel..saaleesssealavilgsvs..sleealealaekd.phlPvlllgesdea 81 
                 k+Lv+ddd   r+ l+ +Le lg +v av+  +   +   ee +++ l+++   +      ++l+ + +++ + +P++++++s+++
  EFC36502.1  91 KVLVVDDDRVARQVLTKLLEQLGFQVKAVEGGKQalEVLREEGNNYHLLLVDVLMPdmDGLQLLKIFRQAYsEDMPIIMVSSSEDP 176
                 79***************************987765433333333333333333222354556666666554267999999988877 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.9
        FleQ   2 iLvidddaerr 12 
                 iL+idd+++++
  EFC36502.1 753 ILIIDDESAQC 763
                 77777766543 PP

>> HD  HD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   4.2e-05     0.094       2      83 ..     446     544 ..     445     579 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.2e-05
                 HHHHHHHHHHHHHHHHHHHH......HHHHHHHHHHHHHTTTTHHHHTS..HHH..HHH........CTCCHHHHHHHHHHHHHHHHHHHHH...HHHH CS
          HD   2 leHsleVaklarrlaedlge......eedrellllaaLlHDiGkgpfgdafekk..eee........fekflaHekvgaeilrevekrlgld...ledv 81 
                 ++H + V ++a  l     +      + ++  l + a++HD+G++ ++ + + +    e           +  H+  + ++l ++ + ++l+   ++++
  EFC36502.1 446 FTHAVDVTQFAYHLLLVD-RisqmfsPMEKFALMFSAIMHDVGHPGVNNNYLINikD-ElaliyndvSVLENHHASQAFYLLLKHNICSNLSkdeFKEF 542
                 677777777777766533.3466778888899**************99977776861.23455566633334588888888888877777766665555 PP

                 HH CS
          HD  82 ak 83 
                  +
  EFC36502.1 543 RR 544
                 44 PP

>> PYRIN  PAAD/DAPIN/Pyrin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.3    0.0039       8.6      34      74 ..     258     297 ..     222     298 .. 0.70
   2 ?    6.2   0.1    0.0051        11       8      47 ..     533     585 ..     529     591 .. 0.66

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0039
                 CCHCT-SHHHHHHHHHHHHTCCCCHHHHHHHHHHTTTHHHH CS
       PYRIN  34 gelekadrvdladlLvehygedaavevtlkvlekinlkdla 74 
                 + ++    + +adl++ +y+ ++    ++ vl+ ++ kdl 
  EFC36502.1 258 TPMQVV-MKTIADLMEGKYSIENSKGALIAVLRSLGSKDLY 297
                 333332.5679*************************99995 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0051
                 CC-HHHHHHHHHHH..........HH....--SSS.HTTHCCHCT-SHHHHHHH CS
       PYRIN   8 eLseeelkkFKslL..........kee...eeglk.siprgelekadrvdladl 47 
                 +Ls++e+k+F++l           + +     +++ ++ +g l k +++d  +l
  EFC36502.1 533 NLSKDEFKEFRRLVistilctdmsH-HfeiLTKFQtRLQTGTLSKESKEDRLQL 585
                 8***********9977777665441.1234333333666777766666665555 PP

>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   3.9   0.00026      0.58      54      99 ..     218     263 ..     202     273 .. 0.87
   2 ?   -0.1   0.1      0.21   4.6e+02      44      76 ..     349     381 ..     333     423 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00026
     DUF3450  54 ralkeeleslevyneqlerlvasqeqeiasleeqieeieeierelv 99 
                 +a +e l++ ++ +++l+  v++qe+e++++++qi++  e+ +++v
  EFC36502.1 218 KAYQEMLQNERINRKKLTLRVKEQEKELEEIKNQINNTVETPMQVV 263
                 5678899999***************************999999886 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.21
     DUF3450  44 dekqellaeyralkeeleslevyneqlerlvas 76 
                 +++q+ +++ ++ ++ +++ ++y +q++++v++
  EFC36502.1 349 KNSQQTKEQSQSSSASNQQVSLYHKQVDDIVTK 381
                 445555555566666666666666666666655 PP

>> Pex14_N  Peroxisomal membrane anchor protein (Pex14p) conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.9    0.0013       2.9      67     113 ..     328     374 ..     291     398 .. 0.45
   2 ?    4.5   1.8     0.023        51      66      93 ..     698     733 ..     671     782 .. 0.52

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0013
     Pex14_N  67 qeesasssatpqpqaasqtsqsspspsppaqqqqqqyrpPivtypef 113
                 ++ + ++s+tp ++++s+t++++++++++++q+++++ +++  y+++
  EFC36502.1 328 NNVNGNKSNTPISNESSPTTEKNSQQTKEQSQSSSASNQQVSLYHKQ 374
                 22223333333333333332222222222222222223444455444 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.023
     Pex14_N  66 a........qeesasssatpqpqaasqtsqsspsps 93 
                 +        +++++++ +t++++++s+t+++++s++
  EFC36502.1 698 KedissthtTTTTKNTITTTTTTKTSTTTTTTNSQE 733
                 111111111111111111111222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (842 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2718  (0.151598); expected 358.6 (0.02)
Passed bias filter:                      721  (0.0402142); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.01u 0.35s 00:00:01.36 Elapsed: 00:00:00.56
# Mc/sec: 4545.55
//
Query:       EFC36503.1  [L=532]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.54   10.4   2.2         14    5.8   0.1    3.5  4  Gemini_AL1_M  Geminivirus rep protein central domain


Domain annotation for each model (and alignments):
>> Gemini_AL1_M  Geminivirus rep protein central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1     0.021   3.8e+02      39      64 ..      81     106 ..      76     141 .. 0.78
   2 ?   -3.0   0.0      0.42   7.6e+03      12      23 ..     186     198 ..     183     205 .. 0.76
   3 ?    5.8   0.1   0.00079        14       9      44 ..     221     256 ..     213     272 .. 0.82
   4 ?   -0.1   0.0     0.056     1e+03      66     105 ..     381     420 ..     349     421 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.021
  Gemini_AL1_M  39 dnlesnadkifpeipeefvppfplss 64 
                    +l ++++k++ e   e+ ++f +s 
    EFC36503.1  81 GRLPNEMEKVYHEYDIEYLSEFHVSL 106
                   5678999**************98774 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.42
  Gemini_AL1_M  12 ali.nasSkeeal 23 
                   ++i na+Skee  
    EFC36503.1 186 DVImNANSKEEVV 198
                   4555999999975 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.00079
  Gemini_AL1_M   9 iakalinasSkeealeiikeelPkDyvlkldnlesn 44 
                    ++ ++  +S ee  +ii+ e P ++   l  + s+
    EFC36503.1 221 NLQSVLRLKSLEELDTIIQSEIPAEWNNDLSDFSSE 256
                   556667889*****************9888887765 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.056
  Gemini_AL1_M  66 tnlpeemqdWvddelgqvsaarperlksiivegesrtgkt 105
                   + ++++ ++ v +++ +++ ++++ ++ ++      t++t
    EFC36503.1 381 HTIQVHFNNLVCQKMKEGAEEKRKNYRCVVWCEAALTSDT 420
                   5678888999999999999999999988776666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (532 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1210  (0.0674884); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 3163.60
//
Query:       EFC36504.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.4e-57  194.2   4.1    4.5e-57  193.8   4.1    1.1  1  ABC_membrane  ABC transporter transmembrane region
    6.1e-35  120.7   0.1    3.4e-34  118.3   0.0    2.2  2  ABC_tran      ABC transporter
    0.00026   21.6   0.6      0.021   15.3   0.0    3.0  3  AAA_23        AAA domain
    0.00035   20.4   2.8     0.0013   18.6   0.0    2.7  3  AAA_15        AAA ATPase domain
     0.0011   18.6   0.1     0.0032   17.2   0.1    1.7  1  AAA_29        P-loop containing region of AAA domain
  ------ inclusion threshold ------
      0.012   15.5   0.1       0.05   13.5   0.0    2.0  2  RsgA_GTPase   RsgA GTPase
      0.016   14.4   0.0      0.033   13.4   0.0    1.5  1  NB-ARC        NB-ARC domain
      0.017   14.4   0.0      0.041   13.2   0.0    1.6  1  Zeta_toxin    Zeta toxin
      0.021   14.6   0.0      0.046   13.5   0.0    1.6  1  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
      0.022   14.9   0.1       0.22   11.6   0.1    2.2  2  DUF87         Helicase HerA, central domain
      0.036   14.5   0.0      0.073   13.4   0.0    1.5  1  AAA_16        AAA ATPase domain
      0.059   13.9   0.0       0.17   12.4   0.0    1.9  1  AAA_18        AAA domain
      0.089   12.5   0.0       0.25   11.1   0.0    1.7  2  AAA_30        AAA domain
      0.096   12.6   0.0       0.25   11.2   0.0    1.7  1  APS_kinase    Adenylylsulphate kinase
       0.12   12.1   0.0        0.2   11.4   0.0    1.3  1  AAA_24        AAA domain
       0.13   12.4   0.1       0.57   10.3   0.0    2.0  2  AAA_33        AAA domain
       0.14   12.5   0.0       0.63   10.3   0.0    2.0  2  AAA_22        AAA domain


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  193.8   4.1   4.3e-60   4.5e-57       4     270 ..     114     380 ..     111     384 .. 0.96

  Alignments for each domain:
  == domain 1  score: 193.8 bits;  conditional E-value: 4.3e-60
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHSCHHHH CS
  ABC_membrane   4 iillailagvlsplfplvlgrildtlldkgdpetealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtnsvGel 100
                   ++ +++++ ++s++ p+  gr++dtl    ++ te+l+++ + l +l+++++++++++ +    +g+++ krlr++lf++ +rq+++ffd++++Gel
    EFC36504.1 114 GMACLAVSAAVSLILPIGVGRLVDTLALPPEQATEQLKLIGYGLSGLFAVSAAAVIGRYTAVQTAGQKIQKRLRKRLFDSYMRQDVQFFDNTKTGEL 210
                   68899*********************8554444478************************************************************* PP

                   HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHTT CS
  ABC_membrane 101 lsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgirtVkafg 197
                   ++rl++dv+ +++ ++ +++  ++sl+   gg+i++++l+ klt v ++i+pl+ + ++v+++ +kkl+k + +++ak++++a+E +s+irtV++f 
    EFC36504.1 211 VNRLSTDVEVVSETITHTIISGMRSLVEASGGIILLCFLSFKLTGVAVSIFPLLGIGAVVYGRYVKKLSKSYLDELAKSTAFAQERISNIRTVRLFS 307
                   ************************************************************************************************* PP

                   THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHH CS
  ABC_membrane 198 reeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfail 270
                   +e+++++++e+++e + ++g++  ia+g++ ++ ++ ++ s++++l +G++ visg+l+vg+l+ fl+++ ++
    EFC36504.1 308 AEKKEVKNYEDKIEHVFNSGRQLGIARGVFYSAVNFGANMSMIAVLALGGFDVISGALTVGKLTSFLLYSIYV 380
                   ********************************************************************99765 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       2.6   2.7e+03      42      80 ..     175     215 ..     154     248 .. 0.64
   2 !  118.3   0.0   3.2e-37   3.4e-34       1     137 []     449     601 ..     449     601 .. 0.95

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 2.6
                 EEETTCEGGGB-HHHCCHCE..EEE-SS--S-TTSBHHHH....H CS
                 xxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxx....x RF
    ABC_tran  42 illdgkdlkeqeleslrkei..gvlpqepqlfpeltvren....e 80 
                 ++  g+++++    +lrk++  +++ q+ q+f++++ +e      
  EFC36504.1 175 VQTAGQKIQK----RLRKRLfdSYMRQDVQFFDNTKTGELvnrlS 215
                 4455555555....4444443378999999999988777665441 PP

  == domain 2  score: 118.3 bits;  conditional E-value: 3.2e-37
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH...................H CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...................x RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren...................e 80 
                 lkn +l++k+g +vaivG +G+GKSt+l+ll++ ++ ++G i++dg+d++  + ++lr +igv++qep lf+ + ++en                   +
  EFC36504.1 449 LKNFNLNIKPGDVVAIVGMSGSGKSTILSLLSRFYDVDNGLITIDGEDIRGLDATWLRTHIGVVSQEPVLFDMT-IEENirygipegvevtmeqiieaA 546
                 79*********************************************************************999.***********9998888888777 PP

                 HHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  81 sdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                 +++++++++ ++ + +  +t++++++  LSgGq+qr++l+r++l +pk+l lDE+t+
  EFC36504.1 547 KKANCHEFIMSFPDGY--NTRIGEKGMGLSGGQRQRISLCRSILLNPKILALDEATS 601
                 7777888888888777..999**********************************96 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1      0.22   2.3e+02     128     173 ..      47      91 ..       6     113 .. 0.56
   2 ?   -0.1   0.0         1   1.1e+03     124     164 ..     278     322 ..     252     330 .. 0.70
   3 !   15.3   0.0     2e-05     0.021      11      37 ..     450     477 ..     442     481 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.22
      AAA_23 128 kkiilnlilflgqerfeefelkdkkerleelekeleeledekklle 173
                 +k+i+n  ++l   +  +f ++++ +r e++eke+++ e+  kl +
  EFC36504.1  47 SKSIFNKPVLLENNSSRNF-TSTTVKRAESVEKEIKKDEENVKLTK 91 
                 3345555555555444333.36677777777777777776666544 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 1
      AAA_23 124 llgskkiilnlilflgqerfeefel....kdkkerleelekelee 164
                 l +s  ++l  +  ++qer  ++++    +++k++++++e+++e+
  EFC36504.1 278 LSKSYLDELAKSTAFAQERISNIRTvrlfSAEKKEVKNYEDKIEH 322
                 444444556666667777755555555556777777888777776 PP

  == domain 3  score: 15.3 bits;  conditional E-value: 2e-05
      AAA_23  11 rdqeidFsk.gltlItGpNGaGKTTild 37 
                 ++++++ ++  +++I+G+ G+GK+Til 
  EFC36504.1 450 KNFNLNIKPgDVVAIVGMSGSGKSTILS 477
                 677778877469**************96 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.62   6.6e+02     145     170 ..      63      88 ..      21     156 .. 0.68
   2 ?   -0.1   0.3      0.55   5.8e+02     170     219 ..     276     325 ..     270     330 .. 0.76
   3 !   18.6   0.0   1.2e-06    0.0013      14      67 ..     449     499 ..     447     549 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.62
      AAA_15 145 kelpkekeeklekekeelkidkedlk 170
                 +++ + + + +e+ ++e+k+d e++k
  EFC36504.1  63 RNFTSTTVKRAESVEKEIKKDEENVK 88 
                 22222333333333333333333322 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.55
      AAA_15 170 kklikkleeslkkeeelknvlksaiiklllisakRnvsdedsekkssllg 219
                 kkl+k +   l k+  + +   s+i++++l+sa+++  ++ ++k++ +++
  EFC36504.1 276 KKLSKSYLDELAKSTAFAQERISNIRTVRLFSAEKKEVKNYEDKIEHVFN 325
                 556665556665555666667899999999**999999999999998875 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 1.2e-06
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnkekknkkvikiekedlei 67 
                 lk++ +++++  +  ++G  +sGKS+il +l  F + +    +  i+i+ ed++ 
  EFC36504.1 449 LKNFNLNIKPGdVVAIVGMSGSGKSTILSLLSRFYDVD----NGLITIDGEDIRG 499
                 789999999989************************99....8999999999875 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.1     3e-06    0.0032      16      39 ..     453     476 ..     447     480 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 3e-06
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                  ++i++ +++ ++G sGsGKST+l
  EFC36504.1 453 NLNIKPGDVVAIVGMSGSGKSTIL 476
                 56788888**************98 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       2.7   2.9e+03      55     113 ..     310     370 ..     290     375 .. 0.72
   2 ?   13.5   0.0   4.7e-05      0.05      84     121 ..     443     481 ..     413     514 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.7
                  -GGG--HHHHHHHHHHHHHHTTSE..EEE--TTTHTTHHHHHHHCTTSEEEEECSTTSSHH CS
  RsgA_GTPase  55 KiDlleeeeeleelkeelealgye..vllvsaktkegleelkellkdktsvlvGqSGvGKS 113
                  K ++ + e+++e++ +  ++lg++  v++  ++ +++++ ++ l  + + v+ G   vGK 
   EFC36504.1 310 KKEVKNYEDKIEHVFNSGRQLGIArgVFYSAVNFGANMSMIAVLALGGFDVISGALTVGKL 370
                  6666666777888888888888653356666667778888877777788888888888884 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 4.7e-05
                  TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCT CS
  RsgA_GTPase  84 aktkegleelkellkd.ktsvlvGqSGvGKStLinallp 121
                   k+ + l++ + ++k  +++++vG SG GKSt++  l  
   EFC36504.1 443 RKEVQVLKNFNLNIKPgDVVAIVGMSGSGKSTILSLLSR 481
                  344445555556677779****************99876 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   3.1e-05     0.033      17      38 ..     457     477 ..     442     486 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.1e-05
                 TSCSEEEEEEESTTSSHHHHHH CS
      NB-ARC  17 elqslvvalvGmgGvGKttlak 38 
                 +++ +vva+vGm G+GK+t+++
  EFC36504.1 457 KPG-DVVAIVGMSGSGKSTILS 477
                 556.79*************986 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   3.9e-05     0.041      17      55 ..     460     498 ..     447     501 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.9e-05
  Zeta_toxin  17 klillgGqpGAGKselaellkdelerqgnvvrldpDdlR 55 
                 +++ ++G +G+GKs++++ll +  + +++ +++d+ d+R
  EFC36504.1 460 DVVAIVGMSGSGKSTILSLLSRFYDVDNGLITIDGEDIR 498
                 578899*******************************99 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   4.4e-05     0.046       2      46 ..     462     506 ..     461     531 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 4.4e-05
      AAA_21   2 nvliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkip 46 
                  +++G  gsGKS++L +l+ + ++d+ ++    e+ +g + ++ +
  EFC36504.1 462 VAIVGMSGSGKSTILSLLSRFYDVDNGLITIDGEDIRGLDATWLR 506
                 689*****************9999777777777777776666655 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.65   6.8e+02     136     212 ..     286     359 ..     268     374 .. 0.65
   2 ?   11.6   0.1   0.00021      0.22      26      44 ..     462     480 ..     460     492 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.65
       DUF87 136 klssdepveklleelkkekeelrklknqaiarlldkledllrkggsfsnsstdliallleklekegkitiidlsgvd 212
                  ++s ++ ++  ++++     l ++ ++  ++++dk+e+++++g++       +  + +++  + + i+++ l+g+d
  EFC36504.1 286 LAKSTAFAQERISNIR--TVRLFSAEKKEVKNYEDKIEHVFNSGRQL-GIARGVFYSAVNFGANMSMIAVLALGGFD 359
                 4444444444444444..34778888999999999999999999999.55555555555777777777777777766 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00021
       DUF87  26 lAilgsTGsGKSntvavLl 44 
                 +Ai+g++GsGKS+  ++L 
  EFC36504.1 462 VAIVGMSGSGKSTILSLLS 480
                 79***********999885 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0     7e-05     0.073      25      51 ..     460     486 ..     442     523 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 7e-05
      AAA_16  25 elvllsGesGvGKsslvrellralekd 51 
                  +v ++G+sG+GKs+++  l r +  d
  EFC36504.1 460 DVVAIVGMSGSGKSTILSLLSRFYDVD 486
                 5799*************9999876655 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   0.00016      0.17       1      20 [.     462     481 ..     462     525 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00016
      AAA_18   1 IlltGtpGvGKttlakeLsk 20 
                 +++ G++G+GK+t+   Ls+
  EFC36504.1 462 VAIVGMSGSGKSTILSLLSR 481
                 689***************87 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       7.8   8.2e+03      54      75 ..     206     227 ..     195     232 .. 0.81
   2 ?   11.1   0.0   0.00023      0.25      19      45 ..     460     486 ..     452     510 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 7.8
      AAA_30  54 ptgkaAkvLaeelgieastiak 75 
                  tg+  ++L++++++ ++ti +
  EFC36504.1 206 KTGELVNRLSTDVEVVSETITH 227
                 6788889999999999999876 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00023
      AAA_30  19 rvavltGpAGtGKttalkalreaweaa 45 
                  v++++G  G+GK+t+l+ l + ++ +
  EFC36504.1 460 DVVAIVGMSGSGKSTILSLLSRFYDVD 486
                 4999**************999988765 PP

>> APS_kinase  Adenylylsulphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00024      0.25       3      42 ..     460     498 ..     458     505 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00024
                 EEEEEESSTTSSHHHHHHHHHHHHHHTT--EEEEEHHHHT CS
  APS_kinase   3 vvvwltGlsgsGKstianalekkLvekgisvylLdGdnvR 42 
                  vv + G+sgsGKsti   l++   +     +++dG+ +R
  EFC36504.1 460 DVVAIVGMSGSGKSTILSLLSR-FYDVDNGLITIDGEDIR 498
                 588999**********999985.67778889999**9999 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00019       0.2       5      44 ..     462     498 ..     459     552 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00019
      AAA_24   5 iliyGpsgiGKTtlakelgpkplfidtekGlksldadkfp 44 
                 ++i+G sg+GK+t+++ l     f d+++Gl  +d+ ++ 
  EFC36504.1 462 VAIVGMSGSGKSTILSLL---SRFYDVDNGLITIDGEDIR 498
                 89****************...6789999999999988765 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       2.4   2.5e+03     102     123 ..     173     194 ..     162     204 .. 0.74
   2 ?   10.3   0.0   0.00054      0.57       1      17 [.     461     477 ..     461     498 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2.4
      AAA_33 102 vvvetdeetlkeRlakRaangd 123
                  +v+t  +++++Rl+kR +++ 
  EFC36504.1 173 TAVQTAGQKIQKRLRKRLFDSY 194
                 5678888899999999987654 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00054
      AAA_33   1 lvllvGlpGsGKstlae 17 
                 +v +vG++GsGKst + 
  EFC36504.1 461 VVAIVGMSGSGKSTILS 477
                 7999**********876 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       3.2   3.3e+03      99     133 ..     198     236 ..     175     239 .. 0.72
   2 ?   10.3   0.0   0.00059      0.63       7      31 ..     461     485 ..     456     510 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3.2
      AAA_22  99 Eaqhlr...seealeeLrsllnl.srkgvqliLvGtpel 133
                 ++q+++   + e+++ L++ +++ s++ ++ i+ G+++l
  EFC36504.1 198 DVQFFDntkTGELVNRLSTDVEVvSETITHTIISGMRSL 236
                 566776543478888886666668899999999999887 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00059
      AAA_22   7 ilvvtGesGtGKTtllrrlleqlde 31 
                 +++++G sG+GK+t l  l + +d 
  EFC36504.1 461 VVAIVGMSGSGKSTILSLLSRFYDV 485
                 789**************99999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       943  (0.0525964); expected 358.6 (0.02)
Passed bias filter:                      652  (0.0363657); expected 358.6 (0.02)
Passed Vit filter:                        92  (0.00513135); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 3569.94
//
Query:       EFC36505.1  [L=526]
Description: hypothetical protein NAEGRDRAFT_59983 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      0.002   17.7   0.0         11    5.7   0.0    4.0  3  CaATP_NAI  Ca2+-ATPase N terminal autoinhibitory domain
     0.0097   15.6   0.4      0.022   14.5   0.3    1.6  2  DUF5058    Domain of unknown function (DUF5058)
  ------ inclusion threshold ------
      0.081   12.6   0.6       0.73    9.4   0.0    2.5  2  FNIP_C     Folliculin-interacting protein C-terminus
       0.87   10.3   0.1       0.87   10.3   0.1    3.4  3  LIN52      Retinal tissue protein
        3.8    7.9   8.9       0.83   10.1   2.3    2.7  3  DUF3632    Protein of unknown function (DUF3632)


Domain annotation for each model (and alignments):
>> CaATP_NAI  Ca2+-ATPase N terminal autoinhibitory domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0     0.004        14       7      26 ..     213     267 ..     209     273 .. 0.78
   2 !    5.7   0.0    0.0032        11      11      29 ..     277     295 ..     269     297 .. 0.83
   3 ?    1.3   0.4     0.076   2.7e+02       2      25 ..     327     350 ..     326     391 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.004
   CaATP_NAI   7 ieaKnsS...................................eEalrrWRqavpl 26 
                 ++ K+sS                                   eE ++ WRq+ ++
  EFC36505.1 213 VPKKSSSqqefktvdekqywkdvlkmikelkkdskqpvdakkEEDRKYWRQVKGM 267
                 6677777777777777777777777777777777888899999********9776 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0032
   CaATP_NAI  11 nsSeEalrrWRqavplvkN 29 
                 n  eE  + WRq+ +l k+
  EFC36505.1 277 NKKEEDKKYWRQVSSLIKS 295
                 5559999*********997 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.076
   CaATP_NAI   2 ddlFdieaKnsSeEalrrWRqavp 25 
                 +++F+ + K +S      WR++  
  EFC36505.1 327 KENFESPKKETSPKDVAYWRDVHK 350
                 689999999999888888888754 PP

>> DUF5058  Domain of unknown function (DUF5058)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.3   6.1e-06     0.022     103     157 ..       3      57 ..       1      67 [. 0.93
   2 ?   -4.1   0.0       2.9   1.1e+04      78      93 ..     100     115 ..      96     126 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6.1e-06
     DUF5058 103 lgaesltaqafatavwvmtlgiigwllvvllftkklekvreklsskdkkllaiis 157
                  ++++ t +++  +v+v++l++++wl+v+  +t++ +++++++++ d kll+i+ 
  EFC36505.1   3 YSKQQSTRTVVGLIVLVLMLCSCCWLVVANSTTQQQQQLENSITKHDLKLLKILA 57 
                 57789999*****************************************999986 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 2.9
     DUF5058  78 RLsviGsaayEltaAe 93 
                 +  v+Gs ++E ++ +
  EFC36505.1 100 KTVVVGSNMTEPMVVK 115
                 5568999999988876 PP

>> FNIP_C  Folliculin-interacting protein C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.1      0.16   5.8e+02      98     128 ..     185     215 ..     170     221 .. 0.81
   2 ?    9.4   0.0    0.0002      0.73      88     164 ..     325     401 ..     317     408 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.16
      FNIP_C  98 skkldevvsmSelVssmLesvvqlyklklsa 128
                 ++ ++++ +  ++V++m+++++  ++ ++++
  EFC36505.1 185 KEVNNKDALYWRQVKDMMKQFKTSNETNVPK 215
                 4567788888899*********999988776 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0002
      FNIP_C  88 lssessklskskkldevvsmSelVssmLesvvqlyklklsaefcigilEdkLqelylkSeaLaellrskesvqleel 164
                 + +e+ ++ k++ ++++v+  + V++m++ v   +kl    ef+   lE kL++     ++L + lr++ +  l+ +
  EFC36505.1 325 MIKENFESPKKETSPKDVAYWRDVHKMIKDVSIKKKLDQDREFISKPLERKLRKWSPSHRVLNKKLRKEMKPALKMI 401
                 5556678889999****************************************988888888888888877555544 PP

>> LIN52  Retinal tissue protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.1   0.00024      0.87      31      67 ..      32      68 ..      23      75 .. 0.89
   2 ?   -1.9   2.6       1.6   5.8e+03      44      55 ..     231     242 ..     185     294 .. 0.59
   3 ?   -3.2   0.0       4.1   1.5e+04      37      77 ..     413     427 ..     392     444 .. 0.52

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00024
       LIN52 31 ssekasepewkeelekddiellnelgsltteqLlekv 67
                +s+++++++++++++k+d++ll+ l++l++ +L++++
  EFC36505.1 32 NSTTQQQQQLENSITKHDLKLLKILAKLSRGKLMKEL 68
                67788999999***********************986 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.6
       LIN52  44 lekddiellnel 55 
                   kd +++++el
  EFC36505.1 231 YWKDVLKMIKEL 242
                 222222333333 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 4.1
       LIN52  37 epewkeelekddiellnelgsltteqLlekvkelqdlayqL 77 
                 ++e++++l++                            y++
  EFC36505.1 413 TKEISKNLKQV--------------------------LYNV 427
                 44444444443..........................3333 PP

>> DUF3632  Protein of unknown function (DUF3632)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.7   6.1e+03     120     143 ..      21      44 ..      10      74 .. 0.67
   2 ?    0.6   3.8      0.18   6.6e+02      23      69 ..     203     258 ..     159     264 .. 0.67
   3 ?   10.1   2.3   0.00023      0.83      18     102 ..     235     331 ..     228     352 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.7
     DUF3632 120 laaAaqWillageeLyelseeekd 143
                 + + ++W++ a+    ++++ e++
  EFC36505.1  21 MLCSCCWLVVANSTTQQQQQLENS 44 
                 566778888887776666555444 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.18
     DUF3632  23 kalrk.........deeeegaktedgerlWsdlpllgaalreedeadskereeeke 69 
                 k++++          +++++ kt+d++++W+d+  + ++l ++++++++ ++ee +
  EFC36505.1 203 KQFKTsnetnvpkkSSSQQEFKTVDEKQYWKDVLKMIKELKKDSKQPVDAKKEEDR 258
                 44444666666666556677888889999999866666666644444444333333 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.00023
     DUF3632  18 Lvellkalrk..deeeegaktedgerlWsdlpllgaalreedeadskereeekeewinlnaFlArltaagvlkd.........slyalwa.....lrea 100
                 +++++k+l+k  + +  +ak+e+++++W++++ + +++r+    + +++ee+k+ w+ +++ +  + + ++ k          s+   w      ++e 
  EFC36505.1 235 VLKMIKELKKdsK-QPVDAKKEEDRKYWRQVKGMMKEFRKP---QDNKKEEDKKYWRQVSSLIKSFGKDRMKKPyglvdekkeSDRTYWInvkrmIKEN 329
                 5678999999963.4455666677799*************3...3345788999999998876665555533335555555554444444555556666 PP

     DUF3632 101 LE 102
                 +E
  EFC36505.1 330 FE 331
                 66 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (526 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2564  (0.143009); expected 358.6 (0.02)
Passed bias filter:                      718  (0.0400469); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 3038.40
//
Query:       EFC36506.1  [L=439]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.2e-25   87.6  14.0    3.8e-09   36.1   0.0    6.3  6  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.1   3.8e-06     0.069       1      33 [.     106     138 ..     106     148 .. 0.91
   2 !   36.1   0.0   2.1e-13   3.8e-09       9      48 ..     216     255 ..     213     256 .. 0.94
   3 !    9.8   0.0   3.5e-05      0.63       1      28 [.     258     285 ..     258     285 .. 0.90
   4 !   32.2   0.7   3.6e-12   6.5e-08       1      45 [.     284     329 ..     284     335 .. 0.94
   5 ?    0.0   0.0     0.039   7.1e+02      22      31 ..     344     353 ..     332     353 .. 0.83
   6 ?    0.3   0.0     0.033   5.9e+02       1      16 [.     376     390 ..     374     402 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.8e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkA 33 
                 + +++le++++n  a+  +s++Lk D  +v +A
  EFC36506.1 106 NPDFMLEYIRRNVAAFLICSKRLKFDPSFVERA 138
                 689***************************998 PP

  == domain 2  score: 36.1 bits;  conditional E-value: 2.1e-13
     DUF4116   9 vkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 vk ng++lky+ eeL+++++iv  Av++ng als+a+ ++
  EFC36506.1 216 VKENGLYLKYCTEELTSNRDIVFTAVQNNGMALSFAHVKF 255
                 899*********************************9766 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 3.5e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDke 28 
                 D Eiv ea+ +n+++++ +s ++  + e
  EFC36506.1 258 DVEIVREALFNNPYSIRLISTSFLDNNE 285
                 569*******************998865 PP

  == domain 4  score: 32.2 bits;  conditional E-value: 3.6e-12
     DUF4116   1 DrEivleavkkngsalky.lseeLknDkeivlkAvkqngtalsyas 45 
                 ++Ei+l+ + +n ++++y ++++++++++++ kA+  n++++s+ +
  EFC36506.1 284 NEEIILNFMARNLCNFEYlIPSKYTSNFDLMRKAIILNPHNYSRTY 329
                 79****************77**********************9865 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.039
     DUF4116  22 eLknDkeivl 31 
                  L++Dke+++
  EFC36506.1 344 TLRHDKELII 353
                 59*****986 PP

  == domain 6  score: 0.3 bits;  conditional E-value: 0.033
     DUF4116   1 DrEivleavkkngsal 16 
                 Dr++vl ++   ++++
  EFC36506.1 376 DRDVVLAVILA-PNNF 390
                 78888888776.3444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (439 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 2616.44
//
Query:       EFC36507.1  [L=488]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.14   11.9   0.1        0.3   10.9   0.1    1.5  1  Rbsn      Rabenosyn Rab binding domain


Domain annotation for each model (and alignments):
>> Rbsn  Rabenosyn Rab binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   1.7e-05       0.3      20      41 ..     162     183 ..     161     184 .. 0.94

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 1.7e-05
        Rbsn  20 rrfDEvatLeeNLkELqeEidr 41 
                 r+++E+  Le N+++L+e+i+r
  EFC36507.1 162 RKYEEAFQLEGNVTMLDEQIAR 183
                 9*******************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       813  (0.0453455); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2878.85
//
Query:       EFC36508.1  [L=305]
Description: glutamine amidotransferase domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      4e-06   26.7   0.1    2.8e-05   24.0   0.1    2.2  2  DJ-1_PfpI  DJ-1/PfpI family


Domain annotation for each model (and alignments):
>> DJ-1_PfpI  DJ-1/PfpI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0     0.038   6.8e+02     105     134 ..      51      80 ..      47      87 .. 0.86
   2 !   24.0   0.1   1.6e-09   2.8e-05      10     150 ..      61     236 ..      56     248 .. 0.69

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.038
                 HHHHHTTTTTTSEE--SGGGHHHHHHTTSE CS
   DJ-1_PfpI 105 qlLaaagvlkgrrvTsypavkdklekagak 134
                 ++L+  g+l+g  +T   +v   l+k+g+k
  EFC36508.1  51 VILSGCGYLDGSEITEAVSVMVHLSKKGYK 80 
                 678889999999999999999999999987 PP

  == domain 2  score: 24.0 bits;  conditional E-value: 1.6e-09
                 TBEHHHHHHHHHHHHHTTEEEEEEESS...............TSEEEETTS..EEEE-SE..EGGGCTCCG-SEEEE--BHHHHHHHHTSH........ CS
   DJ-1_PfpI  10 gvedvElivpvdvlkragikvdvvsvd...............keevkgsrG..lkvtvda..slddvkaaeyDalvlpGGragperlrene........ 81 
                 g e +E+++ +  l++ g+k+    +d               k+ev+  r    ++t      ld+ +++++ al++pGG   +++l++ +        
  EFC36508.1  61 GSEITEAVSVMVHLSKKGYKLAFFAPDinqeetydhltknveKNEVRNIRTeaSRITRQNvlRLDQFRPQAFEALIIPGGFGVAKNLSNYAenptnfki 159
                 56666677777777777777777777777777777766655555555555422222222211356999************9876666553322333333 PP

                 ..HHHHHHHHHHHTT-EEEEETTTHHHHHHTTTTTTSEE-...-SGGGHHHHHHTTSEE-SS...SEEEETT..EEEES CS
   DJ-1_PfpI  82 ..kvvelvkefaekgklvaaICagpqlLaaagvlkgrrvT...sypavkdklekagakyvdk...rvvvdgn..lvTsr 150
                   +v + + + +e++ ++++ C +p+l  aa+ ++++++T   s p+v++  +  ga+ v k   +vvvd++  lvT  
  EFC36508.1 160 hpEVEKAIVSTHEAKIPIGMCCIAPVL--AAKAIPQCSITlgdSDPSVTEHAKSYGANCVPKstsQVVVDKDnkLVTTP 236
                 33999*******************865..5566799999955566777777788888888889*999998876788865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 2114.16
//
Query:       EFC36509.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.8e-17   63.1  15.4    0.00015   22.0   0.4    4.7  4  LRR_4          Leucine Rich repeats (2 copies)
    3.7e-12   46.1   2.5    4.6e-06   26.2   0.9    3.3  3  LRR_9          Leucine-rich repeat
    1.2e-10   41.0  15.0    2.7e-09   36.6   7.0    4.3  4  LRR_8          Leucine rich repeat
     0.0065   16.8  18.8      0.011   16.0  18.8    1.3  1  PNISR          Arginine/serine-rich protein PNISR
  ------ inclusion threshold ------
      0.012   15.4   0.6       0.17   11.7   0.1    2.8  2  SAM_3          SAM domain (Sterile alpha motif)
       0.35    9.4   7.7       0.45    9.1   7.7    1.1  1  Peptidase_S46  Peptidase S46
        1.4    9.2  17.0        3.4    8.0   1.4    4.3  4  LRR_6          Leucine Rich repeat
          2    9.3  13.4        2.1    9.2   0.4    5.3  4  LRR_1          Leucine Rich Repeat
        6.6    5.4   6.1        9.2    4.9   6.1    1.2  1  Presenilin     Presenilin


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   4.4e-06    0.0087       5      43 ..      36      73 ..      35      74 .. 0.90
   2 !   22.0   0.4   7.7e-08   0.00015       6      40 ..      81     114 ..      77     120 .. 0.88
   3 !   19.9   4.2   3.6e-07   0.00072       1      39 [.     122     163 ..     122     165 .. 0.84
   4 !    9.5   0.2    0.0007       1.4       3      29 ..     186     218 ..     176     223 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 4.4e-06
                EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4  5 vLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeLk 43
                +L+L++  +++i++lek++  k+L+L +N  i  + +L+
  EFC36509.1 36 KLYLQHKGVSKIENLEKFTGVKVLWLESN-AIHEIQGLE 73
                79************************666.999988876 PP

  == domain 2  score: 22.0 bits;  conditional E-value: 7.7e-08
                 EE--SS---E-S-.HHH-TT--EEE-.-S-----GG CS
       LRR_4   6 LdLsnNqltdipl.leklpnLkeLdLsgNnlitdld 40 
                 L+L+ N++ +i + +  +++L++L+Ls+N +it ++
  EFC36509.1  81 LYLHENCIEEIKGiFH-CTKLHTLNLSSN-FITHIP 114
                 9***9********666.*********888.999985 PP

  == domain 3  score: 19.9 bits;  conditional E-value: 3.6e-07
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitdl 39 
                 +n ++LdLs N l++i++   l+ l++L  LdLs N l + l
  EFC36509.1 122 TNIQTLDLSTNALKTIDSvrgLRYLTSLNILDLSKNKLFEEL 163
                 799******66*******888889************555555 PP

  == domain 4  score: 9.5 bits;  conditional E-value: 0.0007
                 --EEE--SS.---E-S-HH.....H-TT--EEE CS
       LRR_4   3 LevLdLsnN.qltdiplle.....klpnLkeLd 29 
                 L+ L L +N +l++ip+ +     +lp+L++Ld
  EFC36509.1 186 LRLLRLEGNeMLKKIPNYRkkiigSLPSLTYLD 218
                 88999**9*89******44456646*******8 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0    0.0004      0.79      45     104 ..      35      92 ..      28      94 .. 0.85
   2 !   26.2   0.9   2.3e-09   4.6e-06      48     126 ..      82     160 ..      76     174 .. 0.92
   3 !   13.0   0.0   2.7e-05     0.054     107     164 ..     178     236 ..     163     248 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0004
       LRR_9  45 dtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqela 104
                 d + l+   + k++++  +  +k+l l++n i  i+ glee   ++++l l +n+++e+ 
  EFC36509.1  35 DKLYLQHKGVSKIENLEKFTGVKVLWLESNAIHEIQ-GLEEN-KEISCLYLHENCIEEIK 92 
                 66667788899*********************9995.78876.58999999999999875 PP

  == domain 2  score: 26.2 bits;  conditional E-value: 2.3e-09
       LRR_9  48 dlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                  l +n i ++ g+ +  +l+tl l++n i++i e+l+    n+++l l+ n l+ +  +  l  l +l++l l kn + 
  EFC36509.1  82 YLHENCIEEIKGIFHCTKLHTLNLSSNFITHIPEELGLNCTNIQTLDLSTNALKTIDSVRGLRYLTSLNILDLSKNKLF 160
                 578999*****************************************************************99999765 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 2.7e-05
       LRR_9 107 dPlaslkklellsllknpvtnk.keyrlyviyklkqlrlldfrkvklkereeaeklfks 164
                   l s+k+l+ll l  n + +k ++yr+ +i  l++l+ ld   +  +er   +  +k+
  EFC36509.1 178 TILKSIKDLRLLRLEGNEMLKKiPNYRKKIIGSLPSLTYLDSMPIFDDERRTVTAWMKG 236
                 45889999******9999976648******************99999999988777665 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1     0.024        48      22      59 ..      51      86 ..      35      88 .. 0.78
   2 ?    3.2   0.0     0.038        76       6      40 ..      59      91 ..      54      97 .. 0.47
   3 !   36.6   7.0   1.4e-12   2.7e-09       2      61 .]      99     159 ..      98     159 .. 0.91
   4 ?    1.5   0.2      0.13   2.5e+02       4      30 ..     187     217 ..     184     218 .. 0.43

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.024
                TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8 22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59
                ++++++kvL L +N ++ +  + ++  + +  L+L  N
  EFC36509.1 51 EKFTGVKVLWLESNAIHEI--QGLEENKEISCLYLHEN 86
                5567899**********99..58888888888888777 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.038
                EE-TTS--SEE-TTSSTT-TT--EEE--SS---GG CS
       LRR_8  6 LdLsnNrltslddeaFkglsnLkvLdLsnNllttl 40
                L L +N +++++    + ++    L+L +N+++ +
  EFC36509.1 59 LWLESNAIHEIQGL--EENKEISCLYLHENCIEEI 91
                34444444444322..2224445566666666665 PP

  == domain 3  score: 36.6 bits;  conditional E-value: 1.4e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GG.GGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttl.spgafsgLpsLrsLdLsgNrL 61 
                 +L++L+Ls+N +t+++ e   +++n ++LdLs N l+t+ s + ++ L+sL  LdLs N+L
  EFC36509.1  99 KLHTLNLSSNFITHIPEELGLNCTNIQTLDLSTNALKTIdSVRGLRYLTSLNILDLSKNKL 159
                 79********************************999971568899999999999999997 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.13
                 SEEE-TTS-.-SEE-...TTSSTT-TT--EE CS
       LRR_8   4 tsLdLsnNr.ltsld...deaFkglsnLkvL 30 
                 + L L  N  l++++   ++   +l++L++L
  EFC36509.1 187 RLLRLEGNEmLKKIPnyrKKIIGSLPSLTYL 217
                 4444444444444431114455555555555 PP

>> PNISR  Arginine/serine-rich protein PNISR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0  18.8   5.5e-06     0.011       6     117 ..     226     351 ..     222     365 .. 0.71

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5.5e-06
       PNISR   6 krkaLPAWireGLEKmerEKqkklererrekeraerrkeekkesskeeeeaknprnlakskfdsedeksdeeeeeg................aegedse 88 
                  r++  AW++ GL  +erE +k +++e++ ker++ ++ e+  +++++ee+++++++++ +++++ e+++eeee +                      +
  EFC36509.1 226 ERRTVTAWMKGGLD-AEREERKIMAQEKKDKERRNFEAFEQLIQQSKKEEKEKESKIEREQVEKKVEEQKEEEELEiiedvpirhmscqieeL----VL 319
                 699**********8.9*************9999999888888888888999999999999999999989888877788888888777744441....22 PP

       PNISR  89 ....sqekasskksevdeqespeeeeaarkei.e 117
                     ++e++++ k++    +sp++ ++++++  +
  EFC36509.1 320 editNEEDTQETKQD--LISSPQNLATQEVSKaQ 351
                 333355555555553..33455445554444422 PP

>> SAM_3  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   8.3e-05      0.17      18      59 ..      38      76 ..      36      82 .. 0.87
   2 ?    0.6   0.1      0.26   5.1e+02      30      48 ..     141     159 ..     129     164 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 8.3e-05
       SAM_3 18 WLtakgFskktvesLgklsGaqLfsLskeeLeqicgaaeGsR 59
                +L++kg sk  +e L+k++G + + L+ + + +i g +e ++
  EFC36509.1 38 YLQHKGVSK--IENLEKFTGVKVLWLESNAIHEIQGLEE-NK 76
                9********..6************************555.44 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.26
       SAM_3  30 esLgklsGaqLfsLskeeL 48 
                 + L+ l+  +++ Lsk++L
  EFC36509.1 141 RGLRYLTSLNILDLSKNKL 159
                 5678889999*******98 PP

>> Peptidase_S46  Peptidase S46
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   7.7   0.00023      0.45     287     461 ..     182     356 ..     144     367 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00023
                    HHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHCT-H.HHHTTHHHHHHHHHHHHHHHHHHHHHHHHHTTTTSH CS
  Peptidase_S46 287 emkkdpeirikyasklagleNylKnliGmlealkkkkvlekkqaeeaalrawlkkdpekkekygkalselealvkekrklaersalleeaessgse 382
                      k+    r++ ++ l+++ Ny K++iG l +l+  + +    +e ++++aw+k   + ++  ++ +++ e+  ke+r+ ++ ++l+++ ++++  
     EFC36509.1 182 SIKDLRLLRLEGNEMLKKIPNYRKKIIGSLPSLTYLDSMPIFDDERRTVTAWMKGGLDAER-EERKIMAQEKKDKERRNFEAFEQLIQQSKKEE-- 274
                    44555567889999****************************************9999754.45566666777777777777777777776655.. PP

                    HHHHHHHHHHHHHHHH.......HH-HHHHHHHHHHHHHHCHHHH.CS--HHHHHHHHHHHHHHHHHHS-GGG--S----SS. CS
  Peptidase_S46 383 llslarklvrlaeere...kpdaereeeyqeralealekelerid.kdldaevdkavlaallkeyreklkaerlpavdkvlgk 461
                      +  +k++r + e++   ++++e  e  ++  +++++ ++e+   +d+++e d++  +++l +  ++l+++++++ ++++ +
     EFC36509.1 275 -KEKESKIEREQVEKKveeQKEEEELEIIEDVPIRHMSCQIEELVlEDITNEEDTQETKQDLISSPQNLATQEVSKAQEIVVN 356
                    .3333344443333330001333333344444555555555555556666666666666666555555555555555544433 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   1.4    0.0017       3.4       1      13 [.      96     108 ..      96     111 .. 0.90
   2 ?    4.9   0.8     0.017        33       1      15 [.     120     134 ..     120     136 .. 0.88
   3 ?    5.4   0.3     0.012        23       3      15 ..     147     159 ..     145     160 .. 0.88
   4 ?   -1.7   0.0       2.2   4.3e+03       3       9 ..     212     218 ..     210     218 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0017
       LRR_6   1 snthLteLdLsgN 13 
                 ++t+L +L+Ls+N
  EFC36509.1  96 HCTKLHTLNLSSN 108
                 89**********9 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.017
       LRR_6   1 snthLteLdLsgNdI 15 
                 ++t++++LdLs N +
  EFC36509.1 120 NCTNIQTLDLSTNAL 134
                 69*********9976 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.012
       LRR_6   3 thLteLdLsgNdI 15 
                 t+L  LdLs N++
  EFC36509.1 147 TSLNILDLSKNKL 159
                 89*********86 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 2.2
       LRR_6   3 thLteLd 9  
                 ++Lt+Ld
  EFC36509.1 212 PSLTYLD 218
                 79****8 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       3.7   7.4e+03       5      12 ..      59      66 ..      56      93 .. 0.55
   2 ?    9.2   0.4    0.0011       2.1       1      16 [.      99     114 ..      99     121 .. 0.86
   3 ?    2.3   0.9       0.2   3.9e+02       2      12 ..     149     159 ..     123     168 .. 0.70
   4 ?    1.5   0.1      0.36   7.3e+02       2      18 ..     186     202 ..     185     211 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 3.7
       LRR_1  5 LdLsnnpl 12
                L L++n +
  EFC36509.1 59 LWLESNAI 66
                55555544 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0011
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L +L+Ls+n+++++p
  EFC36509.1  99 KLHTLNLSSNFITHIP 114
                 79**********8776 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.2
       LRR_1   2 LrhLdLsnnpl 12 
                 L  LdLs n l
  EFC36509.1 149 LNILDLSKNKL 159
                 45567777776 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.36
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 Lr L L++n  l ++pn
  EFC36509.1 186 LRLLRLEGNEMLKKIPN 202
                 899******98888887 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   6.1    0.0046       9.2     212     296 ..     212     296 ..     196     362 .. 0.46

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0046
  Presenilin 212 paLiYsatvvvlaaeekkaevaeseeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseae.ssaeesseekese 296
                 p L Y  ++ ++ +e++++++ ++   ++++++++  ++++k++e+++ ++  ++  ++s++e++e++s+ e ++ e++ ee+++e
  EFC36509.1 212 PSLTYLDSMPIFDDERRTVTAWMKGGLDAEREERKIMAQEKKDKERRN-FEAFEQLIQQSKKEEKEKESKIErEQVEKKVEEQKEE 296
                 666666666666555444333333332222222222222222222222.1111111111111111111111101111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2953  (0.164705); expected 358.6 (0.02)
Passed bias filter:                      752  (0.0419432); expected 358.6 (0.02)
Passed Vit filter:                        97  (0.00541023); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.54
# Mc/sec: 2053.60
//
Query:       EFC36510.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-28   99.2  31.2    2.9e-28   99.2  31.2    2.0  1  MBOAT     MBOAT, membrane-bound O-acyltransferase family


Domain annotation for each model (and alignments):
>> MBOAT  MBOAT, membrane-bound O-acyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.2  31.2   1.6e-32   2.9e-28      59     312 ..     158     423 ..     107     459 .. 0.75

  Alignments for each domain:
  == domain 1  score: 99.2 bits;  conditional E-value: 1.6e-32
       MBOAT  59 yfvvgflel.........................klhslslvfrklasaallsklpslleylgYvffyplllvGPilsyseymsfvesplsrllytakr 132
                 yf++ f+ l                         + ++ ++  r+ +s+  +  + +ll yl+Y+f++pl++ GP+ sy  + s+v++++++ l++   
  EFC36510.1 158 YFNILFCRLisynmdyseqlsrvpsdsinatkkeDEQWSEYRQRQETSLNIE-ADFNLLHYLAYIFYTPLFIGGPVCSYTAFISYVKYSTQKELSYG-- 253
                 3333333334444455555788888888888766666777766666666654.479*******************************9999999983.. PP

       MBOAT 133 nfavalyalflgltylilieyvlskicakdftifkmlssa..........qllmrsvimrilllllllfllifdflglwlvalgedilsGlgvngarld 221
                  +     +l++   y il+e+ l+ ++   f+ + ++             +++   vi ++ l+++++++li     ++ ++l +++ +G+        
  EFC36510.1 254 QLIWHTIRLVA---YIILLEIYLHLFYTVGFNDVGFWKEGlwrgkftrvlPPFSVGVIGITTLTFMYMKFLII----WRMFRL-WALWDGIN------- 337
                 33333333333...56666666665555555555555432111111111167888999999999999999999....9*****.******98....... PP

       MBOAT 222 rvadrniygdwenavsfsefwraWNipvhkWLlryvYkplg.skkfklnkslatlatFlfsAvwHglalgyliwfvlrvllllveklimrlv 312
                   +++n+++++ n++ +s+fwr+W+++++ W lry Y+plg s    ++k+ ++ ++F+f A+wH+l ++ l+w + ++ ll++e +++  +
  EFC36510.1 338 --PPENMNRCVNNNYLVSDFWRSWHRSLYMWILRYLYIPLGgS----KSKVWSVWIIFTFIALWHDLWWRWLAWAWINCCLLILEAVFFYAI 423
                 ..8*************************************855....99************************************9887544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       944  (0.0526521); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 3423.90
//
Query:       EFC36511.1  [L=451]
Description: beta-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.5e-70  235.4   0.0    1.2e-69  234.4   0.0    1.5  1  Tubulin          Tubulin/FtsZ family, GTPase domain
    3.6e-41  140.3   0.1    5.5e-41  139.7   0.1    1.3  1  Tubulin_C        Tubulin C-terminal domain
    3.6e-05   24.1   0.0    9.8e-05   22.6   0.0    1.7  1  Misat_Tub_SegII  Misato Segment II tubulin-like domain
    0.00063   19.0   0.0     0.0029   16.9   0.0    1.9  2  Tubulin_2        Tubulin like
     0.0011   18.6   0.0     0.0022   17.7   0.0    1.5  1  Tubulin_3        Tubulin domain


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  234.4   0.0   3.4e-73   1.2e-69       1     196 [.       3     211 ..       3     212 .. 0.99

  Alignments for each domain:
  == domain 1  score: 234.4 bits;  conditional E-value: 3.4e-73
                 EEEEEEEHHHHHHHHHHHHH...HHHCH..............HHHT.....TTEEEEE....EEESBHHHHHTS-GS........EEEE--CCCCTTC- CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiqsdg..........dslesfFsesgkveyiprsvaidtdpqvlneikags..elfnpnklllgkegagnng 87 
                 ei++i+ GqcGnqig ++we++ +ehg++++g          ++++++++e   ++y+pr++++d++p ++++++ag+  ++f+p+++++g++gagnn+
  EFC36511.1   3 EIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGayhgdsdlqlERINVYYNEATGGRYVPRAILMDLEPGTMDSVRAGPygQIFRPDNFVFGQTGAGNNW 101
                 79**************************98889******************999********************************************* PP

                 -TT-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--.GG.G-HHHHHHHHHHHHHHHHT-SEEE CS
     Tubulin  88 aggypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs.efsevvvepynailalkelieesdavi 185
                 a+g+++ g+e+++++l+ +rke+e+cd+lqgf+i +slgGGTGSG+g++++++++eeyp+++++t++v+Ps + s+ vvepyna l++++l+e++d v+
  EFC36511.1 102 AKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVFPSpKVSDTVVEPYNATLSVHQLVENADEVM 200
                 *************************************************************************************************** PP

                 EEEHHHHHCCS CS
     Tubulin 186 vidNdaLlkil 196
                 +idN+aL++i+
  EFC36511.1 201 CIDNEALYDIC 211
                 **********8 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.7   0.1   1.5e-44   5.5e-41       1     125 [.     261     382 ..     261     383 .. 0.99

  Alignments for each domain:
  == domain 1  score: 139.7 bits;  conditional E-value: 1.5e-44
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEESSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEECECT CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirGdvepkevnkavqrikekkkaqfveWiptgikvalnkkspy 99 
                 PrlhF+l+++aPl+s+ +++++ ++v ++t++++++kn+m+++dpr+g+yl++++++rG++++kev++++ ++++k++++fveWip++ik ++++ +p 
  EFC36511.1 261 PRLHFFLIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAASDPRHGRYLTASAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDIPPR 359
                 9************************************************************************************************** PP

                 -TTTSSCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C 100 vkkqskvsvlmlaNttsiaelfkrll 125
                 + k+    +++++N+t+i+e+fkr++
  EFC36511.1 360 GLKMA---ATFIGNSTAIQEMFKRVS 382
                 **999...****************86 PP

>> Misat_Tub_SegII  Misato Segment II tubulin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   2.7e-08   9.8e-05       1      68 [.       2      71 ..       2      87 .. 0.76

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 2.7e-08
  Misat_Tub_SegII  1 rEivtlqlGnyaNyvgtHfWNtQesyftydeeeeesevdhdvlfre...getkqgqvtytPRllivDlkgs 68
                     rEiv +q G+  N +g+ fW +  +    d++    + d+d++       +++ +   y+PR++++Dl+ +
       EFC36511.1  2 REIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGA-YHGDSDLQLERinvYYNEATGGRYVPRAILMDLEPG 71
                     8********************9998887788777.45555555433111223566789*********9754 PP

>> Tubulin_2  Tubulin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0     8e-07    0.0029     138     203 ..     112     176 ..      97     194 .. 0.78
   2 ?   -0.7   0.0      0.18   6.4e+02      53     104 ..     302     348 ..     248     354 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 8e-07
   Tubulin_2 138 alrdaikrlrgsage.eeglnvfVvgSLaGGTGSGiflDvayllrkilkeekqkvkiiglvllPdvf 203
                  ++++++ +r++a++ + +  + ++ SL GGTGSG+   ++  +r+++++      ++ ++++P+v 
  EFC36511.1 112 LIDSVLDVVRKEAEScDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMM--MTFSVFPSPKVS 176
                 566666666665555555566789**************************997..589999999985 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.18
   Tubulin_2  53 detaekageslksrekealsissaevdr.ilrnllreetasaypsieeWlppe 104
                 ++ + + g++l++++++   +s +evd+ +l+ +      +++++  eW+p++
  EFC36511.1 302 ASDP-RHGRYLTASAMFRGRMSTKEVDEqMLNVQN-----KNSSYFVEWIPNN 348
                 2233.567788888888889999999751555553.....3344677999765 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   6.2e-07    0.0022      64     148 ..     120     198 ..     102     238 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 6.2e-07
   Tubulin_3  64 lrpfaeecdqlrglqvftgvddaWG.GfaakylerlrdeygkksilvWvlaleeklkkkkkaklerklkklnkarslkelseqasl 148
                 +r+ ae cd l+g+q+  +     G G ++  + ++r+ey+ + ++++ +   +++ +      +  ++  n + s+++l e+a  
  EFC36511.1 120 VRKEAESCDCLQGFQIAHSLGGGTGsGMGTLLISKIREEYPDRMMMTFSVFP-SPKVS------DTVVEPYNATLSVHQLVENADE 198
                 6999***************99887769***************9987776533.22222......1223445555566666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       533  (0.0297284); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2765.75
//
Query:       EFC36512.1  [L=327]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.3e-23   81.2  17.4    6.3e-23   81.2  17.4    1.9  2  RRP7      Ribosomal RNA-processing protein 7 (RRP7) C-termina
  ------ inclusion threshold ------
       0.14   11.0   3.0       0.22   10.3   3.0    1.3  1  Treacle   Treacher Collins syndrome protein Treacle


Domain annotation for each model (and alignments):
>> RRP7  Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.2      0.25   2.2e+03      28      30 ..      14      16 ..       3      67 .. 0.64
   2 !   81.2  17.4     7e-27   6.3e-23       7     118 ..     209     322 ..     204     323 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.25
        RRP7 28 ekk 30
                 kk
  EFC36512.1 14 PKK 16
                222 PP

  == domain 2  score: 81.2 bits;  conditional E-value: 7e-27
        RRP7   7 eeelqeevdeymeefdkeeeeekkeekkkeeevDeDGfvtVtrgkkaaa.keeaaeekakkkekkkkkkkell.dFYrFQirekkkeelaeLrkkFeeD 103
                 ++++++e+++y++efd +e+e+++  ++ + +vDe G+++V + +++ + + ++ ++k+k k+++ k k++l   FY+FQ+ ekkk+ +++Lr++Fe+D
  EFC36512.1 209 RQDIKAELNQYLKEFDIKEKERMRVINTLRGKVDEKGWTKVFHRGNQGPiHASELKQKKKVKKNNVKIKHQLDlPFYKFQKVEKKKKAFEDLREQFEKD 307
                 789****************************************44444433322223333333333333333357************************ PP

        RRP7 104 kekieelkekrkfkp 118
                 +e ie++k+++kf+ 
  EFC36512.1 308 RELIERMKRQKKFES 322
                 *************85 PP

>> Treacle  Treacher Collins syndrome protein Treacle
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   3.0   2.4e-05      0.22      12      47 ..       9      44 ..       1      48 [. 0.80

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 2.4e-05
     Treacle 12 atqakagkpeedsesSsEedSdseeetpaaktplQa 47
                  q k +k e d  sSs++dSds ++  ++ +p Q 
  EFC36512.1  9 QQQEKPKKIEVDNHSSSDDDSDSSDDEMVTINPKQY 44
                46777788899***************9999999995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (327 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2018  (0.112555); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 2042.00
//
Query:       EFC36513.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-43  147.3   0.0      9e-43  145.9   0.0    1.8  1  AAA              ATPase family associated with various cellul
    1.1e-27   95.8   0.0    8.1e-27   93.0   0.0    2.5  2  Vps4_C           Vps4 C terminal oligomerisation domain
    4.1e-19   68.4   1.6    1.2e-18   66.9   1.6    1.8  1  MIT              MIT (microtubule interacting and transport) 
    2.7e-09   36.7   0.0    2.1e-08   33.8   0.0    2.4  2  AAA_lid_3        AAA+ lid domain
    1.9e-05   24.5   0.0    3.5e-05   23.6   0.0    1.4  1  IstB_IS21        IstB-like ATP binding protein
    2.8e-05   24.2   0.0    0.00015   21.8   0.0    2.2  1  AAA_5            AAA domain (dynein-related subfamily)
    2.9e-05   24.5   0.1    0.00027   21.4   0.0    2.3  1  AAA_16           AAA ATPase domain
    3.3e-05   23.7   0.0    6.3e-05   22.8   0.0    1.4  1  RuvB_N           Holliday junction DNA helicase RuvB P-loop d
    0.00015   21.1   0.0    0.00024   20.4   0.0    1.3  1  TIP49            TIP49 P-loop domain
     0.0002   21.5   0.4      0.001   19.2   0.0    2.2  2  AAA_2            AAA domain (Cdc48 subfamily)
    0.00023   21.2   0.0     0.0014   18.7   0.0    2.1  2  AAA_14           AAA domain
    0.00031   20.0   0.0    0.00064   19.0   0.0    1.5  1  DUF815           Protein of unknown function (DUF815)
    0.00038   20.7   1.4     0.0036   17.6   0.1    3.0  2  AAA_22           AAA domain
    0.00081   19.8   0.0     0.0021   18.4   0.0    1.8  1  RNA_helicase     RNA helicase
    0.00093   19.7   1.0      0.002   18.7   0.0    2.1  1  AAA_18           AAA domain
     0.0011   18.8   0.0     0.0033   17.2   0.0    1.8  1  AAA_24           AAA domain
      0.005   17.3   2.2      0.015   15.7   0.0    2.5  2  AAA_17           AAA domain
     0.0084   16.3   0.0      0.016   15.4   0.0    1.5  1  AAA_33           AAA domain
  ------ inclusion threshold ------
      0.016   14.4   0.5        1.9    7.6   0.0    2.2  2  DUF2075          Uncharacterized conserved protein (DUF2075)
      0.019   14.4   0.0       0.11   11.9   0.0    2.1  2  PhoH             PhoH-like protein
      0.033   13.7   0.0       0.16   11.5   0.0    2.1  2  AAA_7            P-loop containing dynein motor region
      0.034   13.5   0.0      0.078   12.3   0.0    1.5  1  Mg_chelatase     Magnesium chelatase, subunit ChlI
      0.041   13.4   0.4       0.78    9.3   0.1    2.6  2  AAA_25           AAA domain
       0.06   12.4   0.0      0.096   11.8   0.0    1.3  1  Parvo_NS1        Parvovirus non-structural protein NS1
      0.074   13.0   0.0       0.73    9.7   0.0    2.2  2  NACHT            NACHT domain
       0.11   12.1   0.0       0.62    9.8   0.0    2.0  2  Sigma54_activat  Sigma-54 interaction domain
       0.14   11.8   0.0       0.42   10.3   0.0    1.8  2  Viral_helicase1  Viral (Superfamily 1) RNA helicase
       0.57    9.9   3.7        5.1    6.8   0.0    2.3  2  AAA_11           AAA domain
        1.6    7.5   3.1        2.2    7.0   3.1    1.1  1  ALMT             Aluminium activated malate transporter
          2    8.3   0.0          2    8.3   0.0    3.0  3  ATPase_2         ATPase domain predominantly from Archaea
        3.6    8.4   6.4        4.2    8.1   5.0    1.9  1  Ku_C             Ku70/Ku80 C-terminal arm


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  145.9   0.0   1.6e-45     9e-43       1     132 []     171     300 ..     171     300 .. 0.98

  Alignments for each domain:
  == domain 1  score: 145.9 bits;  conditional E-value: 1.6e-45
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTS CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkk 99 
                 +llyGppGtGK++lakava+e++++f+++s+s+l+sk++gesek +r lf+ a++++ psi+f+DEid++++sr ++++++++r+  ++l +++gv k+
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEANSTFFSVSASDLVSKWQGESEKLVRSLFDMARQNK-PSIIFVDEIDSMCSSRGEGDNDSTRRIKTEFLVQMQGVGKD 268
                 69******************************************************8.****************999********************** PP

                 SSTEEEEEEESSGGGSTHHHHSTTSSEEEETTS CS
         AAA 100 eskvivigatnrpdkldpallrgRfdrkieiel 132
                 +s v+v++atn p+ ldpa++ +Rf+r+i+i+l
  EFC36513.1 269 DSGVLVLAATNIPWGLDPAIR-RRFERRIYIPL 300
                 *********************.7*******985 PP

>> Vps4_C  Vps4 C terminal oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       5.5   3.2e+03      35      51 ..     122     138 ..     117     141 .. 0.76
   2 !   93.0   0.0   1.4e-29   8.1e-27       1      61 []     380     440 ..     380     440 .. 0.99

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 5.5
      Vps4_C  35 lkalkkarptVskeDLe 51 
                 + a+ k +p V  eD++
  EFC36513.1 122 EGAIVKEKPNVKWEDVA 138
                 66888899999888875 PP

  == domain 2  score: 93.0 bits;  conditional E-value: 1.4e-29
      Vps4_C   1 ltPCspgdpgaiemtwmdipsdkllePpvtlkDflkalkkarptVskeDLekheeFTkefG 61 
                 ltPCspgd  aiem++ d+psdkll+P+v+ +Df+kal++arp+Vsk+DL+ +++FT++fG
  EFC36513.1 380 LTPCSPGDSSAIEMSLIDVPSDKLLPPDVSKRDFIKALRTARPSVSKDDLHAYDKFTNDFG 440
                 7***********************************************************9 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.9   1.6     2e-21   1.2e-18       4      64 ..      10      72 ..       7      73 .. 0.98

  Alignments for each domain:
  == domain 1  score: 66.9 bits;  conditional E-value: 2e-21
         MIT  4 AlelvkkAveeDnagnyeeAlelYkealelLlqalk.e.kneerrellrekieeYleRaeeLk 64
                A+e +++A+e+D+a+ y+eA +lY ++++ +++a+k e kn++++++l++k+ee + Rae++k
  EFC36513.1 10 AIEHARQAAEKDEAKSYDEAQRLYLKSIDFFMTAIKhEtKNPKKKDMLKQKVEELMGRAEQIK 72
                9***********************************99************************9 PP

>> AAA_lid_3  AAA+ lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.8   0.0   3.6e-11   2.1e-08       3      33 ..     325     355 ..     323     365 .. 0.93
   2 ?   -1.0   0.0       2.7   1.5e+03      28      43 ..     414     429 ..     410     431 .. 0.86

  Alignments for each domain:
  == domain 1  score: 33.8 bits;  conditional E-value: 3.6e-11
   AAA_lid_3   3 dlkeLAerTeGySGADlaalcreAallAlrr 33 
                 d++eLA +T+GySG D++ l+r+A ++ +r 
  EFC36513.1 325 DFDELANLTDGYSGSDISVLVRNALMEPVRT 355
                 9*************************99985 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.7
   AAA_lid_3  28 llAlrrgikeitmedf 43 
                 + Alr  +++++++d+
  EFC36513.1 414 IKALRTARPSVSKDDL 429
                 679*********9998 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   0.0   6.1e-08   3.5e-05      49     118 ..     170     237 ..     161     247 .. 0.77

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 6.1e-08
   IstB_IS21  49 nivllGpsGvGKshlaialgveavraglsvlfvrvedLveelkrarrdg.klaralkrllkvdllilDdlg 118
                 +i+l Gp+G+GKs+la a+++ea  + +s   v+++dLv++ + + ++  +    ++r  k++++ +D++ 
  EFC36513.1 170 GILLYGPPGTGKSYLAKAVATEANSTFFS---VSASDLVSKWQGESEKLvRSLFDMARQNKPSIIFVDEID 237
                 799****************9988665555...579999999887665431444456677778888888875 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.0   2.6e-07   0.00015       2      77 ..     171     239 ..     170     292 .. 0.77

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 2.6e-07
                 EEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--.........--------..G-SEEEEESGGG- CS
       AAA_5   2 vlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraar..egeilvlDEvera 77 
                 +lL GppGtgKs la+ +a   n++++ v      +++dl+ +++  ++ ++lv s +   ar  +++i+++DE++ +
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEANSTFFSV------SASDLVSKWQ--GESEKLVRSLFD-MARqnKPSIIFVDEIDSM 239
                 89*****************9999999976......5678*****9..566666665555.4555899********965 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.0   4.6e-07   0.00027      24      92 ..     167     226 ..     159     259 .. 0.77

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 4.6e-07
      AAA_16  24 p.elvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysalaqalareellrqlldeaesa 92 
                 p   +ll+G++G+GKs l+++++++++ +   f++  + +l      +  +q    e+l+r l d+a+++
  EFC36513.1 167 PwKGILLYGPPGTGKSYLAKAVATEANST---FFSVSASDL------VSKWQGE-SEKLVRSLFDMARQN 226
                 46789******************999887...666666665......3357777.447777777775554 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   1.1e-07   6.3e-05      34      97 ..     169     240 ..     146     246 .. 0.75

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 1.1e-07
      RuvB_N  34 dhvllyGpPGlGkttlakiiakelgvklkitsgPvl.ek....agdlaalltnleek...dvlfideihrls 97 
                   +llyGpPG Gk+ lak +a+e ++++ + s+  l +k    +  l+  l ++ ++    ++f+dei  + 
  EFC36513.1 169 KGILLYGPPGTGKSYLAKAVATEANSTFFSVSASDLvSKwqgeSEKLVRSLFDMARQnkpSIIFVDEIDSMC 240
                 679**********************9988777665414432213456666666654412269******8775 PP

>> TIP49  TIP49 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   4.1e-07   0.00024      25     101 ..     139     217 ..      98     224 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 4.1e-07
                 XXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
       TIP49  25 glvGqkkareaagv....ivelikekklaGravLlaGpsgtGktalaiaiskelgedvpfvalsgsevyslevkktevltq 101
                 gl G k+a + a +    + +l   k+   +++Ll Gp+gtGk+ la a++ e +    f ++s+s++ s     +e l++
  EFC36513.1 139 GLEGAKEALKEAVIlplkFPQLFTGKRTPWKGILLYGPPGTGKSYLAKAVATEAN--STFFSVSASDLVSKWQGESEKLVR 217
                 666766665555441222346788899999**********************987..67999******9988877777765 PP

>> AAA_2  AAA domain (Cdc48 subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   1.4         5   2.9e+03      56      56 ..      78      78 ..      18     128 .. 0.59
   2 !   19.2   0.0   1.7e-06     0.001       6      90 ..     171     249 ..     167     264 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 5
                H CS
       AAA_2 56 l 56
                 
  EFC36513.1 78 K 78
                2 PP

  == domain 2  score: 19.2 bits;  conditional E-value: 1.7e-06
                 EEEE--TTSSHHHHHHHHHHHTT-....-EEEEEGGG---..----THHHHHHHHHTTT-HHHHTTSEEEEETGGG----------- CS
       AAA_2   6 illlgptgvGktelakalaellfvkkekkliradaselle..eeevehlvsrligappgyvgaeegGivllDEidKihpkessgadv 90 
                 ill gp g+Gk++laka+a   +    +++  + as+l    + e+e+lv +l        ++++  i+++DEid  ++++ +g + 
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEAN----STFFSVSASDLVSkwQGESEKLVRSLFDM----ARQNKPSIIFVDEIDSMCSSRGEGDND 249
                 8999*****************99....49999999999996777888888887765....4566788***********974444444 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       2.4   1.4e+03     102     122 ..      53      73 ..      20      81 .. 0.72
   2 !   18.7   0.0   2.4e-06    0.0014       5      75 ..     171     238 ..     168     258 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 2.4
      AAA_14 102 skllskeiatslagrvaeiel 122
                 +k+++k+  ++l gr+++i+ 
  EFC36513.1  53 KKDMLKQKVEELMGRAEQIKT 73 
                 566777788888888888775 PP

  == domain 2  score: 18.7 bits;  conditional E-value: 2.4e-06
      AAA_14   5 lvitGaRrvGKTtllkqlikellvkkesilyinldderdkkladpekllelileklkeekktylflDEiqe 75 
                 +++ G+  +GK++l+k ++ e     + ++ ++  d   k + ++ekl + ++++++++k +++f DEi  
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEAN---STFFSVSASDLVSKWQGESEKLVRSLFDMARQNKPSIIFVDEIDS 238
                 7899***************8888...99999999998888888888999999999767799********76 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.0   1.1e-06   0.00064      18     115 ..     125     235 ..     108     257 .. 0.71

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 1.1e-06
      DUF815  18 pveevdevklddLvgidkqkealvent......eqflegl..pannvLLwGarGtGKSslvkallneyaeeg.....Lrlievekedlkelpklvellr 103
                  v+e  +vk++d+ g++  keal+e +       q+ +g+  p + +LL+G  GtGKS l ka+ +e++++        l+   + + ++l + +  ++
  EFC36513.1 125 IVKEKPNVKWEDVAGLEGAKEALKEAVilplkfPQLFTGKrtPWKGILLYGPPGTGKSYLAKAVATEANSTFfsvsaSDLVSKWQGESEKLVRSLFDMA 223
                 4678888999999999999999999863332223555565126689*********************99987443333344433344444444444455 PP

      DUF815 104 erperfilfvDD 115
                 ++++  i+fvD 
  EFC36513.1 224 RQNKPSIIFVDE 235
                 666677788776 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       4.5   2.6e+03      98     106 ..      27      38 ..      10      75 .. 0.56
   2 !   17.6   0.1   6.2e-06    0.0036       8      61 ..     171     216 ..     169     278 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 4.5
      AAA_22  98 DEaqhlr..s.e 106
                 DEaq+l   s +
  EFC36513.1  27 DEAQRLYlkSiD 38 
                 555555332222 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 6.2e-06
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsst.sskdllrell 61 
                 ++++G++GtGK++l++ ++ ++         ++++++v ++ +  +++   ++l+
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEA---------NSTFFSVSASDLVsKWQGESEKLV 216
                 799******************9.........666666666665554444444444 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   3.6e-06    0.0021       1      78 [.     171     241 ..     171     244 .. 0.62

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.6e-06
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkklklkkkdsvysrnpeddfwdgYtgqevvvidDfgqvkdeenps..dlaelirlvs 78 
                   i+lyGp+g+GKS+lak +a++  +++      sv s +   + w+g +++ v   +D++++++    s   + e+  ++s
    EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEANSTFF-----SV-SASDLVSKWQGESEKLVRSLFDMARQNKP---SiiFVDEIDSMCS 241
                   789**************6666654441.....11.22333345555556666677777776654...3235666666666 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.0   3.5e-06     0.002       1      38 [.     171     229 ..     171     276 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 3.5e-06
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf.....................gvnlrdvakengll 38 
                 Ill G+pG+GK+ lak+++ + ++                     ++ l d+a++n ++
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEANStffsvsasdlvskwqgeseklVRSLFDMARQNKPS 229
                 99****************99876678855555555555555555555555555555554 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   5.7e-06    0.0033       5      78 ..     171     240 ..     169     256 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 5.7e-06
      AAA_24   5 iliyGpsgiGKTtlakel..gpkplfidtekGlksldadkfpdieswedfldevvelaaeladyktlviDtidele 78 
                 il+yGp+g+GK++lak    + +  f+ + + ++ +  ++++   s + +++ ++  +++++  +++++D id ++
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVatEANSTFFSVSA-SDLVSKWQGE---SEKLVRSLFDMARQNKP--SIIFVDEIDSMC 240
                 89***************98877777777777.4466666666...55666666666666555..788888888776 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.2       1.6   9.4e+02      40      70 ..     100     130 ..      89     153 .. 0.73
   2 !   15.7   0.0   2.6e-05     0.015       1      41 [.     174     217 ..     174     258 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 1.6
                 HSSHHHHCTSHHHHHHHHHHHHHHHHHHHHH CS
      AAA_17  40 akardemrklpleekkelqkeaaekiaeeak 70 
                 +ka+++ +k +++ek++l+ +++ +i +e+ 
  EFC36513.1 100 SKAKSKKEKKEEDEKQQLMGQLEGAIVKEKP 130
                 5666777777888888888888888887753 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 2.6e-05
                 EE-TTSSHHHHHHHHHHHHTEEE..EEHHHHHHHHHHTT.TSHS CS
      AAA_17   1 lGgPGsGKgtqceklvekygfth..lsaGdllreeakrg.glak 41 
                 +G+PG GK+ +++ ++ + + t+  +sa+dl+ + + ++ +l++
  EFC36513.1 174 YGPPGTGKSYLAKAVATEANSTFfsVSASDLVSKWQGESeKLVR 217
                 7***************9998776226899**9988765523443 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   2.8e-05     0.016       2      39 ..     171     210 ..     171     259 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.8e-05
      AAA_33   2 vllvGlpGsGKstlaerllkklg..avllssdtlrrrlfg 39 
                 +ll G+pG+GKs+la+ ++ +    ++ +s  +l ++  g
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEANstFFSVSASDLVSKWQG 210
                 6789**************9888877777887775555544 PP

>> DUF2075  Uncharacterized conserved protein (DUF2075)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.3     0.024        14      93     147 ..      25      99 ..       2     124 .. 0.71
   2 ?    7.6   0.0    0.0033       1.9       4      25 ..     171     192 ..     169     236 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.024
     DUF2075  93 ivDEAhrllt.............ksdqaekqseenqlkelmkrakvvvalvDegQelntgeigteee.......l 147
                  +DEA+rl               ++++++k   ++ ++elm ra+ +  ++ e+ e+++g+  t +        +
  EFC36513.1  25 SYDEAQRLYLksidffmtaikheTKNPKKKDMLKQKVEELMGRAEQIKTFLKEKSEIEKGDADTSNGgspaggsV 99 
                 48******9989999999998776666777777999999**9999888889999999888854444355555551 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0033
     DUF2075   4 vlVtGvaGtGKtvvllnllael 25 
                 +l  G +GtGK++++ ++++e+
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEA 192
                 6778**************9998 PP

>> PhoH  PhoH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0         1   5.9e+02     126     148 ..      27      49 ..      25      82 .. 0.80
   2 ?   11.9   0.0    0.0002      0.11      23      44 ..     172     193 ..     168     279 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 1
                 -SGGG--HHHHHHHHTTB-TT-E CS
        PhoH 126 DEAQnttkeqmkmfltRlGensk 148
                 DEAQ +  +++  f+t + +++k
  EFC36513.1  27 DEAQRLYLKSIDFFMTAIKHETK 49 
                 99999999999999999988887 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.0002
                 EEE--TTSSTTHHHHHHHHHHH CS
        PhoH  23 faiGpaGtGKtylavalaveal 44 
                    Gp GtGK+yla a+a ea 
  EFC36513.1 172 LLYGPPGTGKSYLAKAVATEAN 193
                 568**************99875 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00028      0.16      34      70 ..     169     200 ..     165     242 .. 0.65
   2 ?   -2.8   0.0       6.6   3.8e+03     149     173 ..     272     296 ..     270     298 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00028
       AAA_7  34 kpvllvGptGtGKtviikdllkkldkekylsltinfs 70 
                 k +ll+Gp GtGK+ ++k + ++ +++ +++     s
  EFC36513.1 169 KGILLYGPPGTGKSYLAKAVATEANSTFFSV-----S 200
                 568***************9998888333333.....2 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 6.6
       AAA_7 149 vqlvaamgppgggrneitpRllrhf 173
                 v ++aa + p g    i  R+ r++
  EFC36513.1 272 VLVLAATNIPWGLDPAIRRRFERRI 296
                 67899****************9975 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   0.00013     0.078      25      43 ..     171     189 ..     167     209 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00013
  Mg_chelatase  25 lllvGppGsGKtmlakrlp 43 
                   +ll+GppG+GK+ lak+++
    EFC36513.1 171 ILLYGPPGTGKSYLAKAVA 189
                   89*************9976 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.1    0.0013      0.78      36      54 ..     171     189 ..     169     197 .. 0.88
   2 ?    0.7   0.0      0.56   3.2e+02     130     167 ..     216     253 ..     202     262 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0013
      AAA_25  36 allaGapgtGKttlaldla 54 
                 +ll+G+pgtGK+ la  +a
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVA 189
                 69************97766 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.56
      AAA_25 130 vdaleaaieevegvrlvviDplsralgg.densnsdvga 167
                 v+ l + +++ +++  + +D ++++++  +e +n+ +++
  EFC36513.1 216 VRSLFDMARQ-NKPSIIFVDEIDSMCSSrGEGDNDSTRR 253
                 5556667778.78***********999977777766665 PP

>> Parvo_NS1  Parvovirus non-structural protein NS1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   0.00017     0.096     113     136 ..     167     190 ..     156     216 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00017
   Parvo_NS1 113 krntvwfyGpantGktnlaeaIak 136
                 +   +++yGp+ tGk++la+a a+
  EFC36513.1 167 PWKGILLYGPPGTGKSYLAKAVAT 190
                 555699***************986 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0    0.0013      0.73       3      25 ..     171     193 ..     169     198 .. 0.90
   2 ?    0.5   0.0      0.88   5.1e+02      53      99 ..     200     245 ..     193     261 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0013
                 EEEEC-TTTCHHHHHHHHHHHHC CS
       NACHT   3 vilqGeaGsGKTtLlqklalawa 25 
                 ++l G++G GK++L++ +a+++ 
  EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEAN 193
                 7899**************99875 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.88
                 -HCHHHCCCCTS--SSS-CCHHHHCCSCCCEEEEEE-STT-SS-TCH CS
       NACHT  53 sladllfsqlpepaapvsevwavllelperlLlilDglDelvtdlgq 99 
                 s  dl+ + + e+++ v+  + +  +++ ++ + +D +D +++  g+
  EFC36513.1 200 SASDLVSKWQGESEKLVRSLFDMARQNKPSIIF-VDEIDSMCSSRGE 245
                 667777778888888888877766666666655.6999999998888 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0    0.0011      0.62      25      47 ..     171     193 ..     159     220 .. 0.80
   2 ?   -0.5   0.0       1.5   8.6e+02      93     107 ..     227     241 ..     217     298 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.0011
                      EEEECSTTSSHHHHHHHHHHHST CS
  Sigma54_activat  25 vlitGesGtGKellaraiheask 47 
                      +l+ G  GtGK++la+a+ ++ +
       EFC36513.1 171 ILLYGPPGTGKSYLAKAVATEAN 193
                      89**************9976544 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.5
                      TTSEEEEETGGGS-H CS
  Sigma54_activat  93 dgGtlfLDeigelpl 107
                      + +++f+Dei ++  
       EFC36513.1 227 KPSIIFVDEIDSMCS 241
                      557899999999965 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   0.00073      0.42       4      71 ..     174     236 ..     171     240 .. 0.72
   2 ?   -2.7   0.0       6.8   3.9e+03      29      60 ..     353     386 ..     342     391 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00073
  Viral_helicase1   4 hGvpGcGKStlirkllrts.liltvnrptaelltegkpklpnlsvrtvdsflmalvkstkgkililDEy 71 
                       G pG GKS l + ++ +       ++++  l++++  ++++l  + +d + ++ +      i+++DE+
       EFC36513.1 174 YGPPGTGKSYLAKAVATEAnS-TFFSVSASDLVSKWQGESEKLVRSLFDMARQN-K----PSIIFVDEI 236
                      588***********9998753.33455557999999988888866666633333.3....469****97 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 6.8
  Viral_helicase1  29 rptaelltegk..pklpnlsvrtvdsflmalvks 60 
                      ++t+ ++t+ k  + + +l++ t+d++l +++++
       EFC36513.1 353 VRTCQIATHFKvvSGTCHLTGQTCDDMLTPCSPG 386
                      4557788887777888888899999999888876 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   3.9       0.6   3.4e+02     113     168 ..      44     115 ..      12     152 .. 0.60
   2 ?    6.8   0.0    0.0088       5.1      21      42 ..     172     193 ..     161     244 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.6
      AAA_11 113 vekrlekeekaqlakeiskeleklakelrafeeeeek....................eklkkskekskskleqerr 168
                 ++++ ++ +k ++ k++ +el   a++++ f +e+++                    +    +k+k+++k+e e++
  EFC36513.1  44 IKHETKNPKKKDMLKQKVEELMGRAEQIKTFLKEKSEiekgdadtsnggspaggsvsK----AKSKKEKKEEDEKQ 115
                 4444444445556666666666666666665555554555666666666655543321....22222222222222 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0088
      AAA_11  21 liqGPPGtgKTktivellsqll 42 
                 l+ GPPGtgK+    ++  +++
  EFC36513.1 172 LLYGPPGTGKSYLAKAVATEAN 193
                 899********77666666665 PP

>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   3.1    0.0038       2.2     281     386 ..      11     117 ..       3     150 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0038
        ALMT 281 ilseiqapeelrkkfkeelqrvslesak.vlrelaesvkkmkklskveellkevkvaaeeLqskldskskLlvnsekweaakkkekaeeveekkeeeke 378
                 i+   qa+e+ ++k  +e qr+ l+s+   ++ +++++k+ kk+   ++ ++e+   ae++++ l++ks++  +    ++  + +  + ++ k+++ek+
  EFC36513.1  11 IEHARQAAEKDEAKSYDEAQRLYLKSIDfFMTAIKHETKNPKKKDMLKQKVEELMGRAEQIKTFLKEKSEIEKGDADTSNGGSPAGGSVSKAKSKKEKK 109
                 56678999999999999999*999999735899************************************866655555555555554444444444443 PP

        ALMT 379 seskkeea 386
                 +e +k++ 
  EFC36513.1 110 EEDEKQQL 117
                 33333332 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   2.9       8.1   4.7e+03      71      95 ..      50      74 ..       5     149 .. 0.64
   2 ?    8.3   0.0    0.0034         2      17      44 ..     165     192 ..     162     200 .. 0.84
   3 ?    0.1   0.0       1.1   6.3e+02     108     131 ..     217     240 ..     199     338 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 8.1
    ATPase_2 71 eeeekkklekalgiavpkaeleeil 95
                + ++k+ l++++ + +++ae  + +
  EFC36513.1 50 NPKKKDMLKQKVEELMGRAEQIKTF 74
                3344444444444444443332222 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0034
    ATPase_2  17 repneiyfiYGpegsGKtaLlkeiienl 44 
                 r+p++ +++YGp g GK+ L k ++++ 
  EFC36513.1 165 RTPWKGILLYGPPGTGKSYLAKAVATEA 192
                 67888899**************998876 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 1.1
    ATPase_2 108 lllekikkkgkkiiiiiDelqkli 131
                 + l ++ ++ k  ii++De+  + 
  EFC36513.1 217 RSLFDMARQNKPSIIFVDEIDSMC 240
                 455566666676788888876655 PP

>> Ku_C  Ku70/Ku80 C-terminal arm
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   5.0    0.0073       4.2      26      80 ..      47     114 ..      41     130 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0073
                 ---..---SS--HHHHHHHHH-....HHHHHHHHHHHHH...............HHHHH......--- CS
        Ku_C  26 edlpeeledktlpkyeaidkragslleewkelfeleeedke.............kkkekrkaededee 80 
                 e+   + +d++++k+e++  ra+++   +ke+ e+e+ d++             k+k k+++++ede+
  EFC36513.1  47 ETKNPKKKDMLKQKVEELMGRAEQIKTFLKEKSEIEKGDADtsnggspaggsvsKAKSKKEKKEEDEK 114
                 3344499******************999*******999997899999999998866666666655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1147  (0.0639746); expected 358.6 (0.02)
Passed bias filter:                      642  (0.0358079); expected 358.6 (0.02)
Passed Vit filter:                       115  (0.00641419); expected 17.9 (0.001)
Passed Fwd filter:                        32  (0.00178482); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              31  [number of targets reported over threshold]
# CPU time: 0.79u 0.36s 00:00:01.14 Elapsed: 00:00:00.54
# Mc/sec: 2447.15
//
Query:       EFC36514.1  [L=497]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.4e-18   63.7  47.6     0.0025   17.7   0.0   13.4 14  LRR_6     Leucine Rich repeat
    1.5e-13   50.7  70.5      0.012   16.0   2.5   10.4  8  LRR_4     Leucine Rich repeats (2 copies)
    4.6e-05   23.1  56.2     0.0012   18.6   9.5   10.1  8  LRR_8     Leucine rich repeat
  ------ inclusion threshold ------
        0.2   12.3  56.5       0.52   11.1   0.1   13.5 14  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.92   4.1e+03       3      10 ..      20      27 ..      19      27 .. 0.86
   2 ?    1.5   0.4     0.088   3.9e+02       4      11 ..      94     101 ..      91     101 .. 0.87
   3 !    7.0   0.4    0.0016       7.1       3      18 ..     120     135 ..     120     135 .. 0.94
   4 !   12.1   0.1   3.7e-05      0.16       3      24 .]     147     168 ..     145     168 .. 0.90
   5 !    9.2   0.0   0.00029       1.3       3      20 ..     174     191 ..     172     195 .. 0.85
   6 !   12.5   0.2   2.7e-05      0.12       2      24 .]     200     222 ..     199     222 .. 0.90
   7 ?    3.9   0.1     0.015        66       3      17 ..     228     242 ..     226     249 .. 0.83
   8 ?   -3.0   0.1       2.5   1.1e+04       5      18 ..     254     267 ..     253     270 .. 0.75
   9 !    8.0   0.0   0.00073       3.3       3      15 ..     277     289 ..     277     290 .. 0.92
  10 !    5.3   1.0    0.0055        25       2      15 ..     301     314 ..     300     314 .. 0.92
  11 !   17.7   0.0   5.6e-07    0.0025       4      24 .]     330     350 ..     328     350 .. 0.91
  12 ?    2.0   0.0     0.061   2.8e+02       4      24 .]     355     375 ..     352     375 .. 0.88
  13 !    8.0   0.1   0.00071       3.2       8      23 ..     385     400 ..     381     401 .. 0.88
  14 ?    1.5   0.0     0.092   4.1e+02       5      15 ..     462     472 ..     458     480 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.92
       LRR_6  3 thLteLdL 10
                ++Lt+L+L
  EFC36514.1 20 CSLTSLSL 27
                89****97 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.088
       LRR_6   4 hLteLdLs 11 
                 +Lt+LdLs
  EFC36514.1  94 NLTSLDLS 101
                 8******8 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0016
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 ++Lt L + +N+I+De
  EFC36514.1 120 SNLTCLIMEHNHIDDE 135
                 68*************8 PP

  == domain 4  score: 12.1 bits;  conditional E-value: 3.7e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 +++++L+L  NdIg++G+  ++
  EFC36514.1 147 SKIRKLNLFANDIGNVGLLHIS 168
                 789***************9885 PP

  == domain 5  score: 9.2 bits;  conditional E-value: 0.00029
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                 + L +LdL+ N ++D G+
  EFC36514.1 174 RQLNHLDLRRNSFTDIGI 191
                 5799***********997 PP

  == domain 6  score: 12.5 bits;  conditional E-value: 2.7e-05
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  ++L++LdLs N ++++ a+ L+
  EFC36514.1 200 MQNLEYLDLSRNVLSGDSAILLS 222
                 589**************999885 PP

  == domain 7  score: 3.9 bits;  conditional E-value: 0.015
       LRR_6   3 thLteLdLsgNdIgD 17 
                 t++++ +L++N +g 
  EFC36514.1 228 TNIKSINLTSNSLGY 242
                 899********9996 PP

  == domain 8  score: -3.0 bits;  conditional E-value: 2.5
       LRR_6   5 LteLdLsgNdIgDe 18 
                 L+eL L  Nd++ e
  EFC36514.1 254 LEELKLCNNDLNQE 267
                 78898888988765 PP

  == domain 9  score: 8.0 bits;  conditional E-value: 0.00073
       LRR_6   3 thLteLdLsgNdI 15 
                 t+L+ LdLs+N I
  EFC36514.1 277 TKLKVLDLSDNPI 289
                 68*********87 PP

  == domain 10  score: 5.3 bits;  conditional E-value: 0.0055
       LRR_6   2 nthLteLdLsgNdI 15 
                 n++L +LdLs +++
  EFC36514.1 301 NSNLIHLDLSLCKL 314
                 99**********86 PP

  == domain 11  score: 17.7 bits;  conditional E-value: 5.6e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 ++++L L +N+IgDeG++ ++
  EFC36514.1 330 NVKKLYLGFNQIGDEGVMLIS 350
                 6899*************9985 PP

  == domain 12  score: 2.0 bits;  conditional E-value: 0.061
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L L + +I+  G++ L+
  EFC36514.1 355 NLTHLFLPFSNITSRGVKYLC 375
                 7899999999********998 PP

  == domain 13  score: 8.0 bits;  conditional E-value: 0.00071
       LRR_6   8 LdLsgNdIgDeGaeaL 23 
                 LdL+ N Ig+eG++ +
  EFC36514.1 385 LDLANNMIGNEGLTYI 400
                 9************877 PP

  == domain 14  score: 1.5 bits;  conditional E-value: 0.092
       LRR_6   5 LteLdLsgNdI 15 
                 L+ Ld+s N++
  EFC36514.1 462 LEFLDISKNKF 472
                 899******97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.27   1.2e+03      13      28 ..      36      50 ..      13      60 .. 0.52
   2 !    5.3   1.1    0.0065        29      20      40 ..      87     111 ..      68     115 .. 0.58
   3 ?    4.5   0.4     0.011        50       2      39 ..     121     159 ..     120     169 .. 0.75
   4 !    8.0  15.3   0.00086       3.9       2      33 ..     175     211 ..     174     274 .. 0.89
   5 !   16.0   2.5   2.6e-06     0.012       1      31 [.     277     310 ..     277     318 .. 0.87
   6 !   13.7   0.4   1.5e-05     0.066       2      31 ..     330     363 ..     329     368 .. 0.80
   7 !   13.8   3.8   1.3e-05     0.059       4      42 ..     383     426 ..     380     427 .. 0.75
   8 !    9.4   0.6   0.00032       1.4       1      39 [.     434     472 ..     434     480 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.27
                --E-S-HHH-TT--EE CS
       LRR_4 13 ltdiplleklpnLkeL 28
                l +i+ +e + +L++L
  EFC36514.1 36 LEKISEIE-MEHLTQL 50
                33444444.5555555 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0065
                 H...H-TT--EEE-...-S-----GG CS
       LRR_4  20 e...klpnLkeLdL..sgNnlitdld 40 
                 +   +l nL++LdL  s+   +++++
  EFC36514.1  87 AkneNLYNLTSLDLsiSQS-TVESIE 111
                 25557999*****943333.456655 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.011
                 S--EEE--SS---E-S-....HH..H.-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl....le..k.lpnLkeLdLsgNnlitdl 39 
                 nL+ L   +N++ d       l   k l + ++L+L  N    d+
  EFC36514.1 121 NLTCLIMEHNHIDD--EmvkiLTkcKyLSKIRKLNLFAN----DI 159
                 89999999999997..55566557755999999**9446....55 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.00086
                 S--EEE--SS---E-S-..HH...H-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLsgN 33 
                 +L +LdL+ N  tdi+   l+   ++ nL++LdLs+N
  EFC36514.1 175 QLNHLDLRRNSFTDIGIgyLSnssNMQNLEYLDLSRN 211
                 689*****99*****9988446757*********999 PP

  == domain 5  score: 16.0 bits;  conditional E-value: 2.6e-06
                 SS--EEE--SS---.E-S-HHH-TT..--EEE-. CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpn..LkeLdLs 31 
                 ++L+vLdLs+N +    + l++lpn  L +LdLs
  EFC36514.1 277 TKLKVLDLSDNPIMeGASHLQNLPNsnLIHLDLS 310
                 79************7777799999999*****95 PP

  == domain 6  score: 13.7 bits;  conditional E-value: 1.5e-05
                 S--EEE--SS---E-S-..HH.H-TT--EEE-.. CS
       LRR_4   2 nLevLdLsnNqltdipl..le.klpnLkeLdL.s 31 
                 n ++L+L+ Nq+ d +   ++ +l nL++L L  
  EFC36514.1 330 NVKKLYLGFNQIGDEGVmlISsSLYNLTHLFLpF 363
                 789***********999*74436*******9942 PP

  == domain 7  score: 13.8 bits;  conditional E-value: 1.3e-05
                 -EEE--SS-.....--E-S-HHH-TT--EEE-.-S-----GGGG CS
       LRR_4   4 evLdLsnNq.....ltdiplleklpnLkeLdLsgNnlitdldeL 42 
                 e LdL+nN+     lt i+ ++++  L++L+L  N li+dl+eL
  EFC36514.1 383 ELLDLANNMignegLTYISQCNNFSYLEYLYLDINILISDLSEL 426
                 77*******44444555555666777******66*9*****987 PP

  == domain 8  score: 9.4 bits;  conditional E-value: 0.00032
                 SS--EEE--SS---E-S-..HH..H-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..klpnLkeLdLsgNnlitdl 39 
                 +nL++++ + +++ ++     e  +lp L+ Ld+s N    ++
  EFC36514.1 434 QNLKHISARKCMIVKLIEksDEniSLPLLEFLDISKN----KF 472
                 699******9997764444411467*********999....44 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       2.9   1.3e+04      44      51 ..      43      50 ..      36      54 .. 0.49
   2 ?   -0.2   3.5      0.19   8.7e+02      43      61 .]     141     159 ..      94     159 .. 0.59
   3 !    8.0   0.2   0.00055       2.4      21      40 ..     170     189 ..     161     196 .. 0.74
   4 !   18.6   9.5   2.6e-07    0.0012       1      61 []     174     240 ..     174     240 .. 0.85
   5 !   10.6   2.0   8.2e-05      0.37      23      61 .]     226     264 ..     222     264 .. 0.90
   6 !   10.5   5.7   8.5e-05      0.38       2      56 ..     253     307 ..     252     314 .. 0.80
   7 !    4.9   1.5    0.0048        21       2      59 ..     330     390 ..     329     392 .. 0.70
   8 ?    2.7   3.7     0.024   1.1e+02       2      60 ..     408     471 ..     407     472 .. 0.73

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 2.9
                GGTT--S- CS
       LRR_8 44 afsgLpsL 51
                 +++L++L
  EFC36514.1 43 EMEHLTQL 50
                44444443 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.19
                 GGGTT--S-.EEE--SS-- CS
       LRR_8  43 gafsgLpsLrsLdLsgNrL 61 
                   +  L+++r+L+L  N++
  EFC36514.1 141 TKCKYLSKIRKLNLFANDI 159
                 4456688888888888876 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.00055
                 STT-TT--EEE--SS---GG CS
       LRR_8  21 FkglsnLkvLdLsnNllttl 40 
                  + l++L++LdL++N+ t +
  EFC36514.1 170 CEYLRQLNHLDLRRNSFTDI 189
                 55678888888888888776 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 2.6e-07
                 TT-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS---GGGGGGGTT...--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllttlspgafsg...LpsLrsLdLsgNrL 61 
                 ++L+ LdL++N++t+++ +  ++   ++nL++LdLs+N l+  s+  +s+   L++++s++L++N L
  EFC36514.1 174 RQLNHLDLRRNSFTDIGIGYLSNssnMQNLEYLDLSRNVLSGDSAILLSNsqyLTNIKSINLTSNSL 240
                 689**************9988654459**************98877765444499999999999987 PP

  == domain 5  score: 10.6 bits;  conditional E-value: 8.2e-05
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  l+n k+++L++N+l     + +s +++L++L L +N+L
  EFC36514.1 226 YLTNIKSINLTSNSLGYSCVKEISKFKQLEELKLCNNDL 264
                 689999*******99999999************999997 PP

  == domain 6  score: 10.5 bits;  conditional E-value: 8.5e-05
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 +L++L L+nN l+  + e  ++ +++LkvLdLs+N +    +  +++Lp+   ++L
  EFC36514.1 253 QLEELKLCNNDLNQESMEIISKsFTKLKVLDLSDNPIMEG-ASHLQNLPNSNLIHL 307
                 79************999999999************77665.357777776544444 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.0048
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT..--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsg..LpsLrsLdLsgN 59 
                 n+++L+L +N++ + +    ++ l nL++L L   ++t+   + + +  L +++ LdL +N
  EFC36514.1 330 NVKKLYLGFNQIGDEGVMLISSsLYNLTHLFLPFSNITSRGVKYLCDgvLDRIELLDLANN 390
                 6788899999988888888888899999999988888874443333334666666666666 PP

  == domain 8  score: 2.7 bits;  conditional E-value: 0.024
                 T-SEEE-TTS-.-SEE-TTSSTT..-TT--EEE--SS---GGGGGG..GTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNr.ltslddeaFkg..lsnLkvLdLsnNllttlspga..fsgLpsLrsLdLsgNr 60 
                  L++L+L+ N  +++l+   F +  l+nLk+++ +   +  l +++    +Lp L++Ld+s N+
  EFC36514.1 408 YLEYLYLDINIlISDLSELLFVNgnLQNLKHISARKCMIVKLIEKSdeNISLPLLEFLDISKNK 471
                 5899999999999999999998878999999987777776655443114567777777777776 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       1.6   7.4e+03       4      16 ..      14      26 ..      13      36 .. 0.51
   2 ?    1.0   0.9      0.24   1.1e+03       1       8 [.      94     101 ..      94     143 .. 0.64
   3 ?   -1.2   0.1       1.2   5.5e+03       2      17 ..     149     164 ..     148     171 .. 0.55
   4 ?    7.9   0.2    0.0013       5.7       2      21 ..     176     195 ..     175     197 .. 0.85
   5 ?    7.8   0.3    0.0014       6.1       1      14 [.     202     215 ..     202     224 .. 0.80
   6 ?    2.9   0.1     0.054   2.4e+02       1      12 [.     229     240 ..     229     251 .. 0.82
   7 ?    3.7   0.1     0.031   1.4e+02       1      15 [.     253     267 ..     253     277 .. 0.73
   8 ?   11.1   0.1   0.00012      0.52       1      23 []     278     299 ..     278     302 .. 0.83
   9 ?    4.6   0.3     0.015        69       1      12 [.     303     314 ..     303     326 .. 0.80
  10 ?    2.1   0.1     0.099   4.4e+02       1      13 [.     330     346 ..     330     375 .. 0.75
  11 ?    0.3   0.1       0.4   1.8e+03       3      14 ..     383     394 ..     381     407 .. 0.70
  12 ?   -0.2   0.3      0.58   2.6e+03       2      16 ..     409     423 ..     408     434 .. 0.77
  13 ?   -2.1   0.0       2.5   1.1e+04       1      12 [.     435     446 ..     435     454 .. 0.78
  14 ?    2.2   0.1     0.092   4.1e+02       2      13 ..     462     473 ..     461     491 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.6
       LRR_1  4 hLdLsnnpllglp 16
                h+++  ++l++l+
  EFC36514.1 14 HINVLKCSLTSLS 26
                6666556653332 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.24
       LRR_1   1 nLrhLdLs 8  
                 nL++LdLs
  EFC36514.1  94 NLTSLDLS 101
                 78888874 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.2
       LRR_1   2 LrhLdLsnnpllglpp 17 
                  r+L+L  n +++ + 
  EFC36514.1 149 IRKLNLFANDIGNVGL 164
                 6888886666544443 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0013
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L hLdL++n+++++++ +++
  EFC36514.1 176 LNHLDLRRNSFTDIGIGYLS 195
                 88*********999887776 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.0014
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL++LdLs+n l+g
  EFC36514.1 202 NLEYLDLSRNVLSG 215
                 8*********9954 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.054
       LRR_1   1 nLrhLdLsnnpl 12 
                 n ++++L++n+l
  EFC36514.1 229 NIKSINLTSNSL 240
                 789*******98 PP

  == domain 7  score: 3.7 bits;  conditional E-value: 0.031
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L L+nn l + 
  EFC36514.1 253 QLEELKLCNNDLNQE 267
                 59*********9443 PP

  == domain 8  score: 11.1 bits;  conditional E-value: 0.00012
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++LdLs+np+   +++++qnL
  EFC36514.1 278 KLKVLDLSDNPI-MEGASHLQNL 299
                 7**********9.5777777775 PP

  == domain 9  score: 4.6 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL hLdLs + l
  EFC36514.1 303 NLIHLDLSLCKL 314
                 8*******9997 PP

  == domain 10  score: 2.1 bits;  conditional E-value: 0.099
       LRR_1   1 nLrhLdLsnnpl....l 13 
                 n ++L+L+ n++     
  EFC36514.1 330 NVKKLYLGFNQIgdegV 346
                 56899999999844442 PP

  == domain 11  score: 0.3 bits;  conditional E-value: 0.4
       LRR_1   3 rhLdLsnnpllg 14 
                 + LdL nn +++
  EFC36514.1 383 ELLDLANNMIGN 394
                 779999998743 PP

  == domain 12  score: -0.2 bits;  conditional E-value: 0.58
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L++L+L  n+l++ +
  EFC36514.1 409 LEYLYLDINILISDL 423
                 899999888886544 PP

  == domain 13  score: -2.1 bits;  conditional E-value: 2.5
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+h+  + + +
  EFC36514.1 435 NLKHISARKCMI 446
                 89**99888765 PP

  == domain 14  score: 2.2 bits;  conditional E-value: 0.092
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ Ld+s n ++
  EFC36514.1 462 LEFLDISKNKFE 473
                 899******983 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (497 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       612  (0.0341346); expected 358.6 (0.02)
Passed bias filter:                      304  (0.0169558); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 2829.80
//
Query:       EFC36515.1  [L=124]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (124 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 768.77
//
Query:       EFC36516.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.091   13.6   0.4      0.091   13.6   0.4    1.7  2  CTD_bind  RNA polymerase II-binding domain.


Domain annotation for each model (and alignments):
>> CTD_bind  RNA polymerase II-binding domain.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.4   5.1e-06     0.091      41      60 ..      30      49 ..      15      50 .. 0.84
   2 ?   -3.7   0.1         1   1.8e+04      42      50 ..      63      71 ..      59      72 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 5.1e-06
    CTD_bind 41 kapekikkklkrllniWeer 60
                 ++++ k+kl+r+++ W+er
  EFC36516.1 30 AKDKQEKEKLERIISMWKER 49
                468999*************9 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1
    CTD_bind 42 apekikkkl 50
                +pek kkkl
  EFC36516.1 63 KPEKEKKKL 71
                578888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1226  (0.0683808); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1073.67
//
Query:       EFC36517.1  [L=618]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      5e-17   61.0   5.4    1.5e-05   24.8   0.1    4.9  4  NHL             NHL repeat
    2.2e-09   37.5   0.4    2.2e-09   37.5   0.4    2.7  4  BTB             BTB/POZ domain
    6.3e-05   23.3   5.7        4.1    7.8   0.0    5.5  6  Linker_histone  linker histone H1 and H5 family
  ------ inclusion threshold ------
      0.095   12.4   1.4        4.8    6.9   0.0    3.8  6  PCMT            Protein-L-isoaspartate(D-aspartate) O-methylt
       0.33   11.1   4.3         98    3.2   0.1    4.3  4  DUF3420         Domain of unknown function (DUF3420)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.1   2.8e-07     0.001       6      27 ..      15      36 ..      12      37 .. 0.88
   2 !   24.8   0.1   4.1e-09   1.5e-05       1      27 [.      66      92 ..      66      93 .. 0.96
   3 !   15.7   0.0   3.1e-06     0.011       1      27 [.     175     201 ..     175     202 .. 0.92
   4 ?   -0.4   0.0      0.41   1.5e+03      16      25 ..     417     427 ..     417     428 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 2.8e-07
                EEEEETTTEEEEEECCCTEEEE CS
         NHL  6 GvavdsnGdiyVaDsenhrvqv 27
                Gv v+sn+++y+aD++nh v++
  EFC36517.1 15 GVFVSSNNEVYIADFCNHAVRK 36
                77799**************987 PP

  == domain 2  score: 24.8 bits;  conditional E-value: 4.1e-09
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                fnyP++v v+sn+++++aD +nhr+++
  EFC36517.1 66 FNYPSSVFVSSNNEVCIADLHNHRIRK 92
                9************************97 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 3.1e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 ++yP++v v+ ++++y+aD +nhr+++
  EFC36517.1 175 LYYPSSVFVSLTNEVYIADQHNHRIRK 201
                 68999999999**************97 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.41
                 EEEE.CCCTEE CS
         NHL  16 yVaD.senhrv 25 
                 y+ D  +nh++
  EFC36517.1 417 YILDqLNNHCI 427
                 788889****8 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.6   9.4e+03      30      54 ..     175     199 ..     169     202 .. 0.76
   2 ?   -2.2   0.1       1.3   4.8e+03      57      91 ..     331     366 ..     314     377 .. 0.64
   3 ?   -2.3   0.0       1.5   5.3e+03      75      98 ..     393     416 ..     390     428 .. 0.77
   4 !   37.5   0.4   6.1e-13   2.2e-09       9     106 ..     489     589 ..     482     593 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.6
                 HHHH-HHHHHHHTSTTTTTCCCEEE CS
         BTB  30 LaarSpyFkalftskeieessvsei 54 
                 L   S++F +l ++ +i+++++ +i
  EFC36517.1 175 LYYPSSVFVSLTNEVYIADQHNHRI 199
                 6677999999999999999986555 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.3
                 TTSGHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHH CS
         BTB  57 ddvepeafealLefiYtgeleit.seenleelLaaa 91 
                 +  + e++++l++ +  ++ +++ s+e++ ++L + 
  EFC36517.1 331 SSSQQEIIQKLIDSLLYDKNKVKfSKEEVLDVLFIL 366
                 455567777777777666666666677777777665 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.5
                 EEEC-CGGGHHHHHHHH.HHHT-HH CS
         BTB  75 eleitseenleelLaaa.dllqipr 98 
                 +l+++ +e++e+lL++  + + i++
  EFC36517.1 393 NLTFK-WETIENLLKTCkEEFGIQN 416
                 56775.9999999999877887776 PP

  == domain 4  score: 37.5 bits;  conditional E-value: 6.1e-13
                 TTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST....TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHH CS
         BTB   9 elcDvtlvvgdgkefkahkavLaarSpyFkalftsk....eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlkkac 103
                 + +Dv +++g++k +++hk vL+++S+ F+alf s+      ++++    + +  + e +e++++++Y+  ++  +  ++  lL +a + +i+ l++ c
  EFC36517.1 489 KTSDVKIKMGQNKYLYCHKTVLSSSSTLFNALFDSGscfsDLSDDGI-FTPDESEDLELLEIVIKYCYRISIDKIDAVKIIGLLDMAMKHEIQYLINYC 586
                 689*********************************76543344442.3555777889**********99988777899******************** PP

                 HHH CS
         BTB 104 eef 106
                 ++ 
  EFC36517.1 587 KNN 589
                 976 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0011       4.1      34      69 ..      22      53 ..      16      56 .. 0.81
   2 ?    1.9   0.0     0.083     3e+02      42      68 ..      82     108 ..      71     110 .. 0.78
   3 ?    3.7   0.1     0.022        79      44      69 ..     106     131 ..      90     135 .. 0.77
   4 ?   -2.7   0.0       2.3   8.2e+03      51      69 ..     144     162 ..     138     163 .. 0.83
   5 ?    2.7   0.0     0.045   1.6e+02      42      69 ..     191     218 ..     182     222 .. 0.82
   6 !    5.6   0.1    0.0056        20      41      69 ..     228     256 ..     220     259 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0011
  Linker_histone 34 ykvvdvskfksllkkalkkgvekgelvqpkgkGasG 69
                    ++v     ++ ++++a++k +e+g +v + g+G++G
      EFC36517.1 22 NEV----YIADFCNHAVRKILENGNIVTIAGNGTAG 53
                    333....557789******************99988 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.083
  Linker_histone  42 fksllkkalkkgvekgelvqpkgkGas 68 
                     ++ l ++ ++k +e+g ++ + g+G+ 
      EFC36517.1  82 IADLHNHRIRKILENGSIITIAGNGTH 108
                     45667999***********99999975 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.022
  Linker_histone  44 sllkkalkkgvekgelvqpkgkGasG 69 
                        ++ ++k +e+g +v + g+G+ G
      EFC36517.1 106 GTHNQRIRKILENGNIVTIAGNGTYG 131
                     556899*************9988766 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 2.3
  Linker_histone  51 kkgvekgelvqpkgkGasG 69 
                      k +e+g ++ + g+G+ G
      EFC36517.1 144 LKILENGNIITIAGNGTDG 162
                     578999****999999987 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.045
  Linker_histone  42 fksllkkalkkgvekgelvqpkgkGasG 69 
                     ++ + ++ ++k +e+g ++ + g+G+ G
      EFC36517.1 191 IADQHNHRIRKILENGNIITIAGNGTYG 218
                     56678999**************988766 PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.0056
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGasG 69 
                     +++   ++ ++k +e+g +v + g+G++G
      EFC36517.1 228 NAQLNHNQRIRKILENGNIVTIAGNGTAG 256
                     45566799****************99988 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.61   2.2e+03     102     138 ..      18      55 ..       4      60 .. 0.62
   2 ?   -2.6   0.0         1   3.7e+03     117     138 ..     111     133 ..      91     136 .. 0.71
   3 ?   -2.1   0.0      0.73   2.6e+03     116     138 ..     142     164 ..     137     170 .. 0.82
   4 ?    1.2   0.0     0.073   2.6e+02      99     138 ..     180     220 ..     164     225 .. 0.78
   5 ?    6.9   0.0    0.0013       4.8     116     147 ..     235     267 ..     226     275 .. 0.79
   6 ?   -3.1   0.0       1.5   5.4e+03      88     109 ..     454     475 ..     453     501 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.61
                 EEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 102 vsierikelveeakrnlkkldle.nvivvvgDGrkGye 138
                 vs +    +++  ++ ++k   + n++++ g G+ G+ 
  EFC36517.1  18 VSSNNEVYIADFCNHAVRKILENgNIVTIAGNGTAGFS 55 
                 55554444444445555553333399999*****9996 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1
                 HHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 117 nlkkldle.nvivvvgDGrkGye 138
                 +++k   + n++++ g G++G+ 
  EFC36517.1 111 RIRKILENgNIVTIAGNGTYGFS 133
                 44443322489999999999985 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.73
                 HHHHHCTTCSEEEEES-GGGTTG CS
        PCMT 116 rnlkkldlenvivvvgDGrkGye 138
                 ++lk l+  n+i++ g G+ G+ 
  EFC36517.1 142 AQLKILENGNIITIAGNGTDGFS 164
                 567778888***********996 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.073
                 CEEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT  99 grvvsierikelveeakrnlkkldle.nvivvvgDGrkGye 138
                    vs+     ++++ +++++k   + n+i++ g G++G+ 
  EFC36517.1 180 SVFVSLTNEVYIADQHNHRIRKILENgNIITIAGNGTYGFS 220
                 556777777778888899999865556************96 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0013
                 HHHHHCTTC.SEEEEES-GGGTTGGG-SEEEEE CS
        PCMT 116 rnlkkldle.nvivvvgDGrkGyeekaPYdaih 147
                 ++++k   + n++++ g G+ G+   +P++ i+
  EFC36517.1 235 QRIRKILENgNIVTIAGNGTAGFSGDSPFNIIM 267
                 45555433359*******************997 PP

  == domain 6  score: -3.1 bits;  conditional E-value: 1.5
                 HHHHHHHHCTTCEEEEEESBHH CS
        PCMT  88 tavlarlvgekgrvvsierike 109
                 ta++ +++ ++ +++ ie + e
  EFC36517.1 454 TAIFPKMIITEPTAINIEETIE 475
                 8999999999999999997655 PP

>> DUF3420  Domain of unknown function (DUF3420)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.1     0.027        98      36      47 .]      83      94 ..      74      94 .. 0.80
   2 ?    2.5   0.0     0.046   1.6e+02      37      47 .]     106     116 ..      97     116 .. 0.87
   3 ?    1.6   0.1     0.088   3.1e+02      36      47 .]     192     203 ..     183     203 .. 0.87
   4 ?    1.6   0.0     0.085     3e+02      39      47 .]     233     241 ..     226     241 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.027
     DUF3420 36 ddleekrirril 47
                 dl++ rir+il
  EFC36517.1 83 ADLHNHRIRKIL 94
                69*********7 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.046
     DUF3420  37 dleekrirril 47 
                 + +++rir+il
  EFC36517.1 106 GTHNQRIRKIL 116
                 579*******7 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.088
     DUF3420  36 ddleekrirril 47 
                  d ++ rir+il
  EFC36517.1 192 ADQHNHRIRKIL 203
                 689********7 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.085
     DUF3420  39 eekrirril 47 
                 +++rir+il
  EFC36517.1 233 HNQRIRKIL 241
                 89******7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (618 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       765  (0.0426683); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.49
# Mc/sec: 3831.44
//
Query:       EFC36518.1  [L=300]
Description: ATP synthase assembly protein Atp10, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.4e-31  108.4   5.4    4.4e-31  108.0   5.4    1.2  1  ATP-synt_10  ATP10 protein
  ------ inclusion threshold ------
      0.063   13.4   0.1       0.19   11.9   0.1    1.8  1  MbeD_MobD    MbeD/MobD like


Domain annotation for each model (and alignments):
>> ATP-synt_10  ATP10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.0   5.4   4.9e-35   4.4e-31      44     257 .]      68     294 ..      33     294 .. 0.80

  Alignments for each domain:
  == domain 1  score: 108.0 bits;  conditional E-value: 4.9e-35
  ATP-synt_10  44 kdlfdeektekrrkeLeeel.kksyfydlkefrktnGKlFlspk.syfkadkalyfPnlv.....GktLa.....sskeqsledvlkg.kvsvVrlfs 128
                  ++ ++++ ++ +r +++ e+ + s++ ++k++ k++GKlF+s   ++++ +k+  fP        G++ a     ++++++l + +k+ + +++ + +
   EFC36518.1  68 RERLSKHLKN-ERDNIQSEIhRYSPLKEIKSVLKHKGKLFVSMSgQLIPLEKSTVFPSPEvilgdGRNKAvikniNGEQVDLVKKIKQcRATLLFVNF 164
                  3334444444.4566777772569*****************96549**********986666888444335556668888888888763699****** PP

  ATP-synt_10 129 svvgeelvksyfknkeegkdylkdyeelkeenkdlQivdinlienwlKallvklslaslrkklpkerhnkyfiv..srkqlpfeireelkinNlytGY 224
                  ++ g +++k++ +   e+ +   ++++ +++ +++Q +d+++ en + ++l + ++++l++ +p++ h + ++   +++  +f+++++++i+N++t Y
   EFC36518.1 165 TEYGSNMTKEWKEAY-EEFQTQYETSSPSSSVNKTQCIDLSISENYVVSWLESYVTKNLKSVVPEKMHANTLLTflKNNNETFKFKDAVEITNSKTCY 261
                  *************55.33333334556688999***********************************66665547888889**************** PP

  ATP-synt_10 225 vylvDqnlkIRWagsGnateeelellwkcvkgL 257
                  v+++Dq+++IRW g+G+++ +e++ +++++++L
   EFC36518.1 262 VFVIDQQCRIRWRGCGSPEGKEKDFMISAIQQL 294
                  ***************************999886 PP

>> MbeD_MobD  MbeD/MobD like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   2.1e-05      0.19      23      55 ..     172     204 ..     165     210 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.1e-05
   MbeD_MobD  23 lqeWesafaelqrmfeltqrenaaLseqvtgLs 55 
                  +eW++a++e+q+ +e  +   +  + q+ +Ls
  EFC36518.1 172 TKEWKEAYEEFQTQYETSSPSSSVNKTQCIDLS 204
                 69***************9999999999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1452  (0.0809861); expected 358.6 (0.02)
Passed bias filter:                      605  (0.0337442); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.27s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 1829.94
//
Query:       EFC36519.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.5e-30  105.6  21.5    2.7e-28   99.4  21.5    2.9  1  Pex19            Pex19 protein family
    0.00058   19.9   3.5       0.37   10.8   0.3    2.4  2  IL15             Interleukin 15
  ------ inclusion threshold ------
      0.017   14.6   0.6      0.034   13.6   0.6    1.5  1  DNA_gyraseB      DNA gyrase B
      0.034   14.4   7.0       0.27   11.5   0.8    2.8  3  dbPDZ_assoc      Unstructured region between two PDZ domains 
      0.065   12.2   2.2        0.2   10.6   0.1    2.1  2  Vps53_N          Vps53-like, N-terminal
      0.076   13.3   4.9       0.24   11.7   0.8    2.6  3  DUF3446          Early growth response N-terminal domain
        0.1   11.6   2.5       0.19   10.8   0.8    2.0  2  PHA_synth_III_E  Poly(R)-hydroxyalkanoic acid synthase subuni
       0.62   10.3   6.1       0.34   11.2   3.6    1.8  2  CD99L2           CD99 antigen like protein 2
        3.5    8.4   5.2        8.6    7.2   0.1    3.2  4  Occludin_ELL     Occludin homology domain


Domain annotation for each model (and alignments):
>> Pex19  Pex19 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.4  21.5   1.3e-31   2.7e-28      62     230 ..      90     251 ..       1     283 [] 0.61

  Alignments for each domain:
  == domain 1  score: 99.4 bits;  conditional E-value: 1.3e-31
       Pex19  62 s.......kaeeesfqdiikkTlerLkesgdkvdaaaeseeknsddllaqlLkqLeagadvegeggeeg.........edlekmllgmmeqLssKevLy 144
                 +        +++++fq+++++Tl+ L ++ +++++  + +++ +           ++g+d        +         + ++++l++mme L+s ++L 
  EFC36519.1  90 NeleqtegGEKSSNFQNALHNTLNLLNQNVESMNDTTN-TSNTGS----------SSGGD--------NsgeeepvdeGAFSNLLQSMMEVLMSPDILR 169
                 01122223455667777777777777777777777771.111111..........11222........02222334459******************** PP

       Pex19 145 ePlkelnekfpewLeenkeklsaedlerYekQaeivkeIvakFekedysdedkekreeilellqelqelGspPkeLvgdmpegleg 230
                 +P+ el+ek+p wL++n+ k+ +e+++r +kQ++++ +I++++e  +y d      +e +el++ +qe G+pP+e+v+++ ++  g
  EFC36519.1 170 QPMEELREKYPIWLDQNRGKVADEEYQRIQKQYDLCCKICNVYETSKYPDA----IDELIELMKAMQEQGQPPEEIVSQLSKAEGG 251
                 **************************************************9....99*********************95554322 PP

>> IL15  Interleukin 15
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.3   0.00019      0.37      45     129 ..      70     161 ..      50     164 .. 0.65
   2 !    9.6   0.2   0.00043      0.86      92     131 ..     192     229 ..     183     233 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00019
        IL15  45 Ytesdvk.peCkvqalkCfllElrvileeeiekeeeikeevenliknanknlkslkdesktes........eCkeCEeleeknfkeFlqslvki 129
                 +t+++++ ++  ++ +  f++El     e +ek ++ ++ ++n++++ n+n++s++d+++t++        +  e E  +e  f++ lqs++++
  EFC36519.1  70 FTPQEKEvVNHLTEQVTKFFNEL--EQTEGGEKSSNFQNALHNTLNLLNQNVESMNDTTNTSNtgsssggdNSGEEEPVDEGAFSNLLQSMMEV 161
                 665554413555556677999*9..5678888*********************99887766541111111112233445677777777777665 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00043
        IL15  92 nknlkslkdeskteseCkeCEeleeknfkeFlqslvkivq 131
                 ++++++  ++++ +  Ck+C+ +e  ++++ + +l+++++
  EFC36519.1 192 DEEYQR--IQKQYDLCCKICNVYETSKYPDAIDELIELMK 229
                 555555..56667889********************9875 PP

>> DNA_gyraseB  DNA gyrase B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.6   1.7e-05     0.034      45      89 ..      81     125 ..      58     133 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.7e-05
  DNA_gyraseB  45 ysenilsFvNniatpeGGtHvdgfksaltktlneyakkkkllkkk 89 
                   +e++  F N  +++eGG   + f++al +tln   ++ + ++++
   EFC36519.1  81 LTEQVTKFFNELEQTEGGEKSSNFQNALHNTLNLLNQNVESMNDT 125
                  5789****************************9888777666655 PP

>> dbPDZ_assoc  Unstructured region between two PDZ domains on Dlg5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.8   0.00013      0.27      43      68 ..      19      44 ..      11      50 .. 0.88
   2 ?    5.9   0.1    0.0075        15      12      47 ..      49      84 ..      45      87 .. 0.92
   3 ?   -1.8   0.1       1.9   3.8e+03      27      31 ..     132     136 ..     118     166 .. 0.51

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00013
  dbPDZ_assoc 43 tlseqDeGtmtPpskqttPatspkns 68
                 +l e De + tP+s + t a+sp  s
   EFC36519.1 19 ALNEFDEAPKTPSSEKKTSASSPVAS 44
                 689********************887 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0075
  dbPDZ_assoc 12 sRsssrlesvsnqstpqgsGattPdnhsiidtlseq 47
                 + sss+le+  +        + tP+++ +++ l+eq
   EFC36519.1 49 ASSSSNLEPNDIDLDDILQKTFTPQEKEVVNHLTEQ 84
                 5699**********999999***************9 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.9
  dbPDZ_assoc  27 pqgsG 31 
                    +sG
   EFC36519.1 132 GSSSG 136
                  22222 PP

>> Vps53_N  Vps53-like, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.2     0.069   1.4e+02      25      70 ..      76     116 ..      50     161 .. 0.61
   2 ?   10.6   0.1    0.0001       0.2     129     202 ..     191     265 ..     183     270 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.069
     Vps53_N  25 elikklqeeikklddeiksvvraqanvgekgkealeeaqkaieelf 70 
                 e++++l e++ k  +e+++++ ++ ++  + ++al+   ++++ l 
  EFC36519.1  76 EVVNHLTEQVTKFFNELEQTEGGEKSS--NFQNALH---NTLNLLN 116
                 344555555555555555444433321..1122222...2233333 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.0001
     Vps53_N 129 skrsykeivsllqavlqllnhFekYkdvekIaeLsesisklkkslk..sqiledfkeaFssgsqkeketgnllekl 202
                   ++y+ i ++++  ++++n++e  k  + I eL e +++++++ +  ++i++++++a ++gs++e +  +ll+ l
  EFC36519.1 191 ADEEYQRIQKQYDLCCKICNVYETSKYPDAIDELIELMKAMQEQGQppEEIVSQLSKA-EGGSEEESQVQKLLQGL 265
                 5679**********************************99988654338999999999.68888888888777755 PP

>> DUF3446  Early growth response N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.8   0.00012      0.24      32      60 ..      25      53 ..      11      71 .. 0.68
   2 ?    2.4   0.2     0.098   1.9e+02      20      52 ..     111     136 ..      94     165 .. 0.57
   3 ?   -2.1   0.0       2.5   4.9e+03      24      52 ..     228     253 ..     212     263 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00012
     DUF3446 32 nppsspsssssssssssssssspslscsv 60
                ++p +pss   +s+ss+ +sss+ +s+s 
  EFC36519.1 25 EAPKTPSSEKKTSASSPVASSSADASSSS 53
                57889999666666666666666665554 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.098
     DUF3446  20 llslvs.glvgvanppsspsssssssssssssss 52 
                  l+l+  ++ +++ ++ ++ + ss        s+
  EFC36519.1 111 TLNLLNqNVESMNDTTNTSNTGSS--------SG 136
                 566666444466433333332222........22 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 2.5
     DUF3446  24 vsglvgvanppsspsssssssssssssss 52 
                 +     ++++ ++p    s+ s +   s+
  EFC36519.1 228 MK---AMQEQGQPPEEIVSQLSKAEGGSE 253
                 33...454455555556666655555444 PP

>> PHA_synth_III_E  Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.8   9.4e-05      0.19      41     107 ..      66     131 ..      60     169 .. 0.84
   2 ?   -1.0   0.0      0.36   7.2e+02     213     232 ..     219     238 ..     195     248 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 9.4e-05
  PHA_synth_III_E  41 spkeasdaakelmermveqqkayfrlleqfakafadkdasasavedaweqlekaieqlqkafqglis 107
                      ++k++ ++ ke++++++eq +++f+ leq   + +++++++++  + ++ l++ +e ++ +++ +  
       EFC36519.1  66 LQKTFTPQEKEVVNHLTEQVTKFFNELEQTEGGEKSSNFQNAL-HNTLNLLNQNVESMNDTTNTSNT 131
                      678999***********************99988888887777.89999999999999988765433 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.36
  PHA_synth_III_E 213 ksverlreklqeaaekgkqi 232
                      +++++l+e +++++e+g+++
       EFC36519.1 219 DAIDELIELMKAMQEQGQPP 238
                      46677777777777777665 PP

>> CD99L2  CD99 antigen like protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   3.6   0.00017      0.34       3      74 ..      16     104 ..      10     159 .. 0.56
   2 ?   -1.9   0.0       1.9   3.7e+03      49      91 ..     227     269 ..     214     280 .. 0.53

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00017
      CD99L2   3 Ledalddkkektkkp.altttttkaPkkttkkPakkkpkpaeaddldLsDAl...............dkkndikkkgkkkg..............gseg 71 
                 Le+al++  e++k+p ++++t++  P++++ + +  +  + e++d+dL D l               +            +              g+++
  EFC36519.1  16 LENALNEFDEAPKTPsSEKKTSASSPVASSSA-DASSSSNLEPNDIDLDDILqktftpqekevvnhlT------------EqvtkffneleqtegGEKS 101
                 67788888888888844567888899976544.45666699***********6666544333333331............1234444444433323333 PP

      CD99L2  72 gtf 74 
                 ++f
  EFC36519.1 102 SNF 104
                 333 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.9
      CD99L2  49 LsDAldkkndikkkgkkkg.......gseggtfsdddledvaegggykPD 91 
                 L  A++++ + +      +       ++egg+ +++++++  +g +++ D
  EFC36519.1 227 LMKAMQEQGQPP------EeivsqlsKAEGGSEEESQVQKLLQGLKFT-D 269
                 444444333322......022233446677777777777777777666.4 PP

>> Occludin_ELL  Occludin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0         3   5.9e+03      26      71 ..      11      28 ..       3      40 .. 0.41
   2 ?    7.2   0.1    0.0043       8.6      49      98 ..      72     121 ..      59     124 .. 0.85
   3 ?   -0.7   0.1       1.2   2.5e+03      64      71 ..     193     200 ..     151     217 .. 0.59
   4 ?    1.8   0.3       0.2     4e+02      17      60 ..     217     260 ..     192     269 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3
  Occludin_ELL 26 elhaeleevskkfseLerelkelkegskeykkieeeilqeykklkk 71
                  +l + le++ ++f                             +  k
    EFC36519.1 11 DLDDILENALNEF----------------------------DEAPK 28
                  3333333333333............................33333 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0043
  Occludin_ELL  49 kegskeykkieeeilqeykklkkdpeyqekkkrceyLkekLshiKklike 98 
                   +++++ +++++e++ + +++l++++   +  +  + L++ L+ + + +++
    EFC36519.1  72 PQEKEVVNHLTEQVTKFFNELEQTEGGEKSSNFQNALHNTLNLLNQNVES 121
                   556668999************99999999999999*********999975 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 1.2
  Occludin_ELL  64 qeykklkk 71 
                   +ey++++k
    EFC36519.1 193 EEYQRIQK 200
                   22333322 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.2
  Occludin_ELL  17 FnkeYkeYkelhaeleevskkfseLerelkelkegskeykkiee 60 
                   + +  +e  el + ++e  +  +e+ ++l++++ gs+e++++++
    EFC36519.1 217 YPDAIDELIELMKAMQEQGQPPEEIVSQLSKAEGGSEEESQVQK 260
                   44445566667777777777777777778877777776666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1595  (0.088962); expected 358.6 (0.02)
Passed bias filter:                      812  (0.0452898); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 1730.93
//
Query:       EFC36520.1  [L=483]
Description: mitochondrial processing peptidase beta subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.5e-35  121.7   0.3    5.2e-35  120.6   0.1    1.7  2  Peptidase_M16    Insulinase (Peptidase family M16)
    3.7e-17   62.9   0.1    6.6e-17   62.1   0.1    1.4  1  Peptidase_M16_C  Peptidase M16 inactive domain


Domain annotation for each model (and alignments):
>> Peptidase_M16  Insulinase (Peptidase family M16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  120.6   0.1   5.8e-39   5.2e-35       2     148 ..      76     222 ..      75     223 .. 0.97
   2 ?   -3.5   0.0         1   9.3e+03      97     112 ..     399     414 ..     382     436 .. 0.57

  Alignments for each domain:
  == domain 1  score: 120.6 bits;  conditional E-value: 5.8e-39
                    EEEEE-TSSSEEEEEEEES-SGGGSCTTTTTHHHHHHHHTTSBBSSSCHHHHHHHHHHTTCEEEEEEESSEEEEEEEEEGGGHHHHHHHHHHHHHS CS
  Peptidase_M16   2 valesdppaktsavglvvdaGSryepkdlnGlAHllehmafkgTkkypsnklaeeleklGgslnAttsrentvYyvevlskdlekaldvladvfka 97 
                    v++ ++++   s v+l+v+aGSr e+ + +G++H++e+++f++T++++  +l++el+k G+s++A+t re++vY++e+l+++++ +++++a+ + +
     EFC36520.1  76 VVSTDSTSRGVSVVSLFVNAGSRFETYRTSGVSHFVEKFFFSSTNNRSLLRLTSELQKTGASVSAQTGREHIVYQAEALRESVPLVVELMANSVLQ 171
                    667777788999************************************************************************************ PP

                    BTTSHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHTTTSGGGSHSS-T CS
  Peptidase_M16  98 plleesevererkvvekeveavdaepekvveenlhaaayrekalgrsllgp 148
                     +l ++++e + ++v++++++++++ + v+ e+lh +a++ ++lgrsll+p
     EFC36520.1 172 GRLHPWDLEPKAEAVKRDISEFQNNAQFVLNEALHHTAFNGETLGRSLLCP 222
                    **********999*************************************9 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1
                    SBTTSHHHHHHHHHHH CS
  Peptidase_M16  97 aplleesevererkvv 112
                    +++l+ +++e  ++ +
     EFC36520.1 399 QSTLTAKALEGAKNHA 414
                    4556666666555533 PP

>> Peptidase_M16_C  Peptidase M16 inactive domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.1   0.1   7.3e-21   6.6e-17       2     181 ..     229     412 ..     228     414 .. 0.94

  Alignments for each domain:
  == domain 1  score: 62.1 bits;  conditional E-value: 7.3e-21
                      H-HHHHHHHHHHHSSGGGEEEEEEESS-HHHHHHHHHHHHTTSTHHSHCSGSCTSSSSSGGGSSEEEEEEEESSSSSEEEEEEEEEECTCTHTT CS
  Peptidase_M16_C   2 ltredlkefykkfYrpenmvlaivGdvdheelvkliekyfgdlkaskappakptgepltpatlkkppvvlkkldeeqahlslafegpskended 95 
                      ++ + + +++++ Y + +m+l+    ++heel++l++ +f+++++   + ++  +++ +  ++ +++  +++     +++ la++gps+ +  +
       EFC36520.1 229 IDTDIVLSYMNNLYVAPRMTLVGTN-ISHEELKELANVLFSSIPSQVSERPEGEHFTFEKSEYVGGDLQIHEHSHAGTQAILAYKGPSL-TCSK 320
                      7778899****************99.******************988777888888888889***********99**************.**** PP

                      HHHHHHHHHHHHSS..........TTSHHHHHHHTTTTSESEEEEEEEEESSCEEEEEEEEEECT.THHHHHHHHHHHHHHHHHHTS-HHHHHH CS
  Peptidase_M16_C  96 dlalavlntlLggg..........mesrLytnlrekeglaysvsafndsyrdsglfgisatadpe.nveevvevilkelrklkkeglteeeler 178
                      + a  vl++lLg++            srL + ++     ++  s+f++sy+d glfg+ + +++  +v  +v+ +++el  ++++ lt ++le 
       EFC36520.1 321 HVAYLVLSELLGQTtnkytgsvnhSASRLAKSVK----NVEFGSSFVSSYSDNGLFGVFLAGKNAkEVSSAVQSTVAELSSVQST-LTAKALEG 409
                      **********************************....4666777899999************9999999***************.******** PP

                      HHH CS
  Peptidase_M16_C 179 akn 181
                      akn
       EFC36520.1 410 AKN 412
                      **8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       590  (0.0329076); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.44
# Mc/sec: 3315.16
//
Query:       EFC36521.1  [L=455]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.6e-34  116.9   0.0    1.8e-33  115.9   0.0    1.5  1  Methyltr_RsmB-F  16S rRNA methyltransferase RsmB/F
    3.3e-09   36.7   0.0    6.9e-09   35.7   0.0    1.5  1  Methyltransf_31  Methyltransferase domain
    3.3e-06   27.7   0.0    8.3e-06   26.4   0.0    1.7  1  Methyltransf_25  Methyltransferase domain
    0.00032   20.1   0.0    0.00079   18.8   0.0    1.6  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
  ------ inclusion threshold ------
        1.5    9.8   7.5         15    6.5   1.0    3.2  3  DUF4065          Protein of unknown function (DUF4065)


Domain annotation for each model (and alignments):
>> Methyltr_RsmB-F  16S rRNA methyltransferase RsmB/F
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.9   0.0   4.9e-37   1.8e-33      11     165 ..     280     433 ..     273     449 .. 0.95

  Alignments for each domain:
  == domain 1  score: 115.9 bits;  conditional E-value: 4.9e-37
                      EEEESS-TTSHHHHHHHHHTTTTSEEEEEESSCCCH.HHHHHHHHHTT--SEEEEES-CTCCHHHHCC..EEEEEEEE--CCGGGTTT-TCHHH CS
  Methyltr_RsmB-F  11 tilDlcaaPGgKTthiaelmknkgtvvAvdankeRl.krvaenlkrLgvtntivleaDarkidkvlggelfDriLlDaPCsgtgvirrdpdvkl 103
                       ilD c++ GgKT   a  ++ kg+++  d+ +e+l  ++++  +rLg++n++ +e D ++ dk   +  +  +L D+PC+gtg++rr+ + k+
       EFC36521.1 280 LILDYCCGTGGKTFAFAGCLNGKGQIYMHDVRSEKLfPELKRRAQRLGIENIQPIEHDHSHWDKLKDK--MNLVLCDVPCTGTGTLRRNVETKY 371
                      59****************************999987479***********************998876..9*********************** PP

                      H--HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEES--STTTTHHHHHHHHHH-TTEEEESS CS
  Methyltr_RsmB-F 104 rrkekdiaqlaklqkellsaaidllkkgGvlvYsTCsvlveEneevieeaLkkredvelvet 165
                      + + + +++l+++q+++++ ai+ +k++G+ +YsTCs+l +Ene+++e +Lkk ++ +lv+t
       EFC36521.1 372 KINYQWLQELTEKQRDIIQKAIPFVKQDGYFLYSTCSILKKENEKQLEWILKKYKNFQLVHT 433
                      **********************************************************9987 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.7   0.0   1.9e-12   6.9e-09       7     119 ..     281     414 ..     278     444 .. 0.80

  Alignments for each domain:
  == domain 1  score: 35.7 bits;  conditional E-value: 1.9e-12
  Methyltransf_31   7 vlDlGCGtGeltfelaeelgpkaevvGiDiseeai.elArenaqklgldnveFeqgdieeleklledekfDlilsn................ev 83 
                      +lD+ CGtG +tf++a  l+ k++++  D   e +    + +aq+lg++n++  + d  + +kl + +k +l+l++                  
       EFC36521.1 281 ILDYCCGTGGKTFAFAGCLNGKGQIYMHDVRSEKLfPELKRRAQRLGIENIQPIEHDHSHWDKL-K-DKMNLVLCDvpctgtgtlrrnvetkY- 371
                      79***************************7666662677779*************999998874.5.8********88888877766665551. PP

  Methyltransf_31  84 l.......naladpdkileeiervlkpggilliedprllaelp 119
                               ++  + +i+++++  +k++g++l +++++l++  
       EFC36521.1 372 KinyqwlqELTEKQRDIIQKAIPFVKQDGYFLYSTCSILKKEN 414
                      055666688888999**********************333322 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.0   2.3e-09   8.3e-06       1      70 [.     281     353 ..     281     372 .. 0.92

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 2.3e-09
                      EEEET-TTSHHHHHHHCTS.TSSEEEEEES.SHHHHHHHHHHHHHTTT.TEEEEESBCCGBSSSTTTEEEEEE CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrl.gkakvtgvDi.seemleaareraeeegl.nvefvqgdaedlpfedgsfDlvvs 70 
                      +Ld +cGtG  t+a+a  l gk+++++ D+ se++  + ++ra++ g+ n++ +++d ++++  +++++lv++
       EFC36521.1 281 ILDYCCGTGGKTFAFAGCLnGKGQIYMHDVrSEKLFPELKRRAQRLGIeNIQPIEHDHSHWDKLKDKMNLVLC 353
                      8***************99977********9778889********9999**************9999*****99 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   2.2e-07   0.00079      33     105 ..     264     336 ..     251     352 .. 0.81

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 2.2e-07
                      HHHHHHHHHH--S--TTEEEEES-TT-HHHHHHHHHHHHHHEEEEEES.-HHHHHHHHHHHHHHTSSTEEEEE- CS
  Ubie_methyltran  33 rlWkkfveklvavkrgakvlDvagGtgDlafklsdsvgekgkvvvlDi.nenmLkvgekklkeegkinieflqa 105
                      +l ++ v+k   ++++  +lD ++Gtg  +f+++  ++ kg++ + D+ +e+++ + ++++++ g  ni+ +  
       EFC36521.1 264 ELIRNIVMKEIKTLKPL-ILDYCCGTGGKTFAFAGCLNGKGQIYMHDVrSEKLFPELKRRAQRLGIENIQPIEH 336
                      56677777777777764.9****************************95577889999*******999886654 PP

>> DUF4065  Protein of unknown function (DUF4065)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.2   4.3e+03      51      87 ..      35      76 ..      16     115 .. 0.45
   2 ?    6.5   1.0    0.0042        15      39      97 ..     154     213 ..     134     219 .. 0.69
   3 ?    5.6   0.1     0.008        29      59      99 ..     379     429 ..     355     434 .. 0.65

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.2
     DUF4065 51 ekeeeisdeklekkekkeveeleddkeae.......lseeekev 87
                +++   + ++++  +++++++   + +++       + ee k++
  EFC36521.1 35 QQQLFSTYQYINRINQIKIKQ--LGPNSNllpksvtFVEENKKT 76
                333333333333333333322..222222445555533333333 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0042
     DUF4065  39 d.eikelgskpieekeeeisdeklekkekkeveeleddkeaelseeekevidkvikkykd 97 
                 d +++ l+++++++++++ s++++++++ ++  + ++++ ++ + +ek +++k+i+++++
  EFC36521.1 154 DlKFNSLSNNSNIISNNNNSSNNTSSNNSENNDNSNSSNISNNNSNEKIILKKFINRLSN 213
                 4356666677667777777776777766666555555555559999**********9987 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.008
     DUF4065  59 eklekkekkeveeleddkeae........................lseeekevidkvikkykdls 99 
                 ++l++k              +                        l++e  + +++++kkyk+++
  EFC36521.1 379 QELTEK--------------QrdiiqkaipfvkqdgyflystcsiLKKENEKQLEWILKKYKNFQ 429
                 222222..............112222334455556777888889899999999*********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (455 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1819  (0.101456); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.48u 0.21s 00:00:00.69 Elapsed: 00:00:00.39
# Mc/sec: 3486.76
//
Query:       EFC36522.1  [L=239]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1588  (0.0885716); expected 358.6 (0.02)
Passed bias filter:                      258  (0.0143901); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1409.83
//
Query:       EFC36523.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       596  (0.0332422); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 901.16
//
Query:       EFC36524.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.6e-29  101.5   0.0    9.8e-29  100.7   0.0    1.4  1  RNA_ligase      RNA ligase
  ------ inclusion threshold ------
      0.015   14.9   0.2       0.13   11.9   0.2    2.3  1  DNA_ligase_A_M  ATP dependent DNA ligase domain
       0.07   12.7   0.0        5.7    6.5   0.0    2.2  2  AHJR-like       REase_AHJR-like
      0.086   12.7   0.0       0.16   11.8   0.0    1.4  1  RNA_lig_T4_1    RNA ligase


Domain annotation for each model (and alignments):
>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.7   0.0   2.2e-32   9.8e-29       2     160 ..     164     327 ..     163     328 .. 0.87

  Alignments for each domain:
  == domain 1  score: 100.7 bits;  conditional E-value: 2.2e-32
                 EEEEEEE-SSEEEEEEEETT.EEEEETTCEBCTTTHHHHHHTHHHHHHHHHHHHH....ECCEEEEEEEES.SS.......TTSS.EEEEEEEEEEECT CS
  RNA_ligase   2 evvvtEKlDGtnfriylvke.vgvasRsqilpfgeekfkefkrwaaalrkklkekla..neelilyGElighsi.....kygglpkefyvFdifdirdk 92 
                 ++ vt+KlDG+++++y  ++ +gv+ R+ +l    ++  ++ +w+aa+r+k+ e l+  n++l+l+GE+ig+si     k     ++fy+Fdi+di+  
  EFC36524.1 164 KFEVTVKLDGSSMTVYRKDDhIGVCGRNWEL----RETATNAQWHAARRNKMIEGLQflNRNLALQGEIIGESIqgnleKL--KGQDFYLFDIYDID-- 254
                 789**************9667**********....678889**********999999**889************6643222..335**********9.. PP

                 TBECE--HHHHHHHHHCCT.......B..EEEEE.SS.HHHHHCCC.....HHHHTC--EEEEEESSSSBETTEBSEEEE CS
  RNA_ligase  93 eeqrylspdevealakglg.......tvpvlyegkfl.aaeellel...l.lskgnkrEGlVikpeselyknkgraifKv 160
                  + +yl+p e++ l k+l+       +vp+l   + + +ae++l++   + l+k+ krEGlV+k  ++      +++fK+
  EFC36524.1 255 -KAQYLTPIERQSLVKQLNdngftvkHVPILDDLELNhTAEQILAMadgPsLNKNVKREGLVFKRLDG------KFSFKA 327
                 .**********99999887888999******9999988888888889885448899********8877......777776 PP

>> DNA_ligase_A_M  ATP dependent DNA ligase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.2   2.9e-05      0.13      13      82 ..     156     230 ..     147     337 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.9e-05
                     HHHHTTTSEEEEEEEESSEEEEEEEETTEEEEEETTS-...B-GG...GCHHHHHHHHHHBSTTESEEEEEEEEEE CS
  DNA_ligase_A_M  13 alkkleekafivEiKyDGeRaqvhkegdkvklfSRrlk...dita...akpelvkalkeafkkdeksvilDGElva 82 
                      ++++++++f v +K+DG  + v +++d++ +  R+ +   + t+   +  +  k+++ + +   +++ l GE++ 
      EFC36524.1 156 QIEENKGQKFEVTVKLDGSSMTVYRKDDHIGVCGRNWElreTATNaqwHAARRNKMIEGLQFL-NRNLALQGEIIG 230
                     5678899****************************9652114555766556666666555555.589999999985 PP

>> AHJR-like  REase_AHJR-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0    0.0013       5.7      64     105 ..     142     183 ..     126     200 .. 0.82
   2 ?    3.9   0.0    0.0082        37      14      36 ..     265     287 ..     254     301 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0013
   AHJR-like  64 rssaseqyLqelakaveqhpgWrfelvmtndedatvsikaee 105
                 +s++ ++  q+l  ++e+ +g +fe++++ d  ++ ++++++
  EFC36524.1 142 ISKTDQERVQNLIPQIEENKGQKFEVTVKLDGSSMTVYRKDD 183
                 67889999*******************988877777766655 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.0082
   AHJR-like  14 eslaeqyrekGyevllhPnredl 36 
                 +sl +q++++G++v   P  +dl
  EFC36524.1 265 QSLVKQLNDNGFTVKHVPILDDL 287
                 6899***********99988886 PP

>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   3.7e-05      0.16      28     212 ..     148     326 ..     146     332 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.7e-05
  RNA_lig_T4_1  28 EveetkweeieqktqgpyelteKenGclilisalsdgklvvaSkhsleaeshaevgerllekklekegkteeeLaeelleknlTavfElcddsfeeh 124
                   E+ ++   +ie+++ +++e+t K +G+  +++  +d+++ v+ ++    ++ a  ++ + +    +++k  e L  + l++nl +  E++ +s + +
    EFC36524.1 148 ERVQNLIPQIEENKGQKFEVTVKLDGSSMTVY-RKDDHIGVCGRNWE-LRETATNAQ-WHAA---RRNKMIEGL--QFLNRNLALQGEIIGESIQGN 236
                   5666677799**********************.999********998.344433333.4443...445555555..467889999999999988888 PP

  RNA_lig_T4_1 125 ivaypeekagLyLhglnentp.efstes.seevakfakefgfiktklitlesle...evkkfleevaetgswege.eiEGfVvrc.kskkdffFk 212
                     +   + +  yL ++ +  + ++ t    +++ k  ++ gf ++++  l++le   +++++l ++a+  s +++ + EG V +  +  k f Fk
    EFC36524.1 237 LEKL--KGQDFYLFDIYDIDKaQYLTPIeRQSLVKQLNDNGFTVKHVPILDDLElnhTAEQIL-AMADGPSLNKNvKREGLVFKRlDG-K-FSFK 326
                   7777..577789999999888777765557778888888888888888888887774444444.455555544434899999988454.4.4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      584  (0.0325729); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 2264.71
//
Query:       EFC36525.1  [L=514]
Description: kinase C2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.5e-16   58.7   0.0    1.3e-15   57.6   0.0    1.6  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.6   0.0   7.1e-20   1.3e-15       3      92 ..      22     109 ..      20     120 .. 0.93

  Alignments for each domain:
  == domain 1  score: 57.6 bits;  conditional E-value: 7.1e-20
                 EEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHH CS
          C2   3 levtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvWnekftfevaeleeakLeveVfdndrlskddfiGkveiplstll 92 
                 l++t + Ak+L +kd ++ sdpyv  ++     +k++v++++l+P+Wne++++++ e++++ + ++V+d+d+  +ddf G   ++ls++ 
  EFC36525.1  22 LTITLMGAKDLVPKDRNNLSDPYVLTTY-PGFSHKSKVKPKTLDPIWNETIQIPLIENSNEGINFRVMDKDM-ISDDFEGDYILKLSEIS 109
                 89**************************.************************99999**************.9************9954 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       652  (0.0363657); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 3406.90
//
Query:       EFC36526.1  [L=695]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.4e-33  113.5  18.6    4.2e-16   59.1   7.0    3.9  3  HMG_box    HMG (high mobility group) box
    4.8e-21   75.1  20.5    1.4e-10   41.6   0.7    3.7  3  HMG_box_2  HMG-box domain
  ------ inclusion threshold ------
      0.011   15.7   2.9      0.053   13.5   0.2    3.0  3  CHDNT      CHDNT (NUC034) domain
       0.41   10.8   3.2          2    8.6   1.8    2.5  2  SAM_Exu    Exuperantia SAM-like domain
        3.5    8.3   6.5        1.7    9.4   0.9    2.8  3  KfrA_N     Plasmid replication region DNA-binding N-term


Domain annotation for each model (and alignments):
>> HMG_box  HMG (high mobility group) box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.1   0.00013      0.45      37      64 ..     455     482 ..     453     485 .. 0.89
   2 !   49.4   0.9   1.3e-16   4.6e-13       1      57 [.     554     610 ..     554     612 .. 0.97
   3 !   59.1   7.0   1.2e-19   4.2e-16       1      65 [.     614     678 ..     614     680 .. 0.96

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00013
                 HHHHHSHHHHHHHHHHHHHHHHHHHHHH CS
     HMG_box  37 ekWkalseeeKkkYeekaekekaryeke 64 
                 ++W+ l+++eK++Y+e a + + ++ ++
  EFC36526.1 455 AQWQLLHDSEKQHYIELALASQREMLQQ 482
                 58****************9999888776 PP

  == domain 2  score: 49.4 bits;  conditional E-value: 1.3e-16
                 --SS--HHHHHHHHHHHHHHHHSTTS-HHHHHHHHHHHHHHSHHHHHHHHHHHHHHH CS
     HMG_box   1 pkRplsafflfskeqraklkaenPelknaeiskklgekWkalseeeKkkYeekaeke 57 
                 +k+pls ++ f+k   +++ +  P++  ++i+k +g+kWka++e+eK++Y+e+a+++
  EFC36526.1 554 VKKPLSGYNSFVKSVFPSFQEMYPNIDKKQITKLIGQKWKAMPEDEKQPYIEMARQA 610
                 59****************************************************986 PP

  == domain 3  score: 59.1 bits;  conditional E-value: 1.2e-19
                 --SS--HHHHHHHHHHHHHHHHSTTS-HHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHH CS
     HMG_box   1 pkRplsafflfskeqraklkaenPelknaeiskklgekWkalseeeKkkYeekaekekaryekek 65 
                 +k+pl+a+++++ke+   +k+enP+l  +e+s++++  Wk+ ++eeK+kY++ aek k++ e+++
  EFC36526.1 614 VKKPLNAYNIYCKEKYSIFKEENPDLAPNEVSRMVASSWKKAKKEEKQKYYDLAEKWKQESEEMI 678
                 59*********************************************************988865 PP

>> HMG_box_2  HMG-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.4   0.00089       3.2      42      64 ..     456     478 ..     442     485 .. 0.86
   2 !   41.6   0.7     4e-14   1.4e-10       1      61 [.     551     610 ..     551     616 .. 0.96
   3 !   32.5   7.8   2.7e-11   9.9e-08       5      66 ..     615     675 ..     611     680 .. 0.94

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00089
                 HHHHS-HHHHHHHHHHHHHHHHH CS
   HMG_box_2  42 kWkalseeeKekYeekAkedkkr 64 
                 +W++l ++eK+ Y e A + + +
  EFC36526.1 456 QWQLLHDSEKQHYIELALASQRE 478
                 8***************9776655 PP

  == domain 2  score: 41.6 bits;  conditional E-value: 4e-14
                 ---.-SS--HHHHHHHTTHHHHHHHT---SSHHHHTGGGHHHHHHS-HHHHHHHHHHHHHH CS
   HMG_box_2   1 pkkpkaarnAYalfvqemipelkrkGnpviglaevsklcsekWkalseeeKekYeekAked 61 
                 +++ k + ++Y+ fv+   p  ++  +p i  + ++kl+++kWka++e+eK++Y e+A++ 
  EFC36526.1 551 ANRVKKPLSGYNSFVKSVFPSFQEM-YPNIDKKQITKLIGQKWKAMPEDEKQPYIEMARQA 610
                 58999********************.*********************************86 PP

  == domain 3  score: 32.5 bits;  conditional E-value: 2.7e-11
                 -SS--HHHHHHHTTHHHHHHHT---SSHHHHTGGGHHHHHHS-HHHHHHHHHHHHHHHHHHH CS
   HMG_box_2   5 kaarnAYalfvqemipelkrkGnpviglaevsklcsekWkalseeeKekYeekAkedkkryd 66 
                 k + nAY+++ +e+    k++ np    +evs+ + ++Wk  ++eeK+kY++ A ++k++ +
  EFC36526.1 615 KKPLNAYNIYCKEKYSIFKEE-NPDLAPNEVSRMVASSWKKAKKEEKQKYYDLAEKWKQESE 675
                 6788*****************.************************************9864 PP

>> CHDNT  CHDNT (NUC034) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.9   6.7e+03      18      27 ..     214     223 ..     213     225 .. 0.79
   2 ?   13.5   0.2   1.5e-05     0.053      12      47 ..     558     593 ..     556     597 .. 0.95
   3 ?    0.7   0.1      0.14   5.2e+02      27      47 ..     633     653 ..     630     657 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.9
       CHDNT  18 FsqhvRPlll 27 
                 ++ ++RP+l 
  EFC36526.1 214 YELYIRPILH 223
                 7779***996 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 1.5e-05
       CHDNT  12 ltnyKlFsqhvRPlllkenPkvavsklvmLvaakwr 47 
                 l+ y +F + v P  ++ +P++ ++++ +L+  kw+
  EFC36526.1 558 LSGYNSFVKSVFPSFQEMYPNIDKKQITKLIGQKWK 593
                 78999******************************9 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.14
       CHDNT  27 lkenPkvavsklvmLvaakwr 47 
                  +enP +a + + ++va  w+
  EFC36526.1 633 KEENPDLAPNEVSRMVASSWK 653
                 589*****************9 PP

>> SAM_Exu  Exuperantia SAM-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.25   9.1e+02      32      65 ..     569     602 ..     566     607 .. 0.86
   2 ?    8.6   1.8   0.00054         2      13      63 ..     644     693 ..     639     694 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.25
     SAM_Exu  32 yesLkeiweekkkeGlekllkekitslkeedkee 65 
                 + s +e++ +  k+ ++kl+ +k + + e++k+ 
  EFC36526.1 569 FPSFQEMYPNIDKKQITKLIGQKWKAMPEDEKQP 602
                 5678999*****************9999999875 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00054
     SAM_Exu  13 keRvravklRrlLAEngidyesLkeiweekkkeGlekllkekitslkeedk 63 
                   R  a+ + +   E++ +y  L e w+++++e + +++ ek t+ k++++
  EFC36526.1 644 VSRMVASSWKKAKKEEKQKYYDLAEKWKQESEEMISTAV-EKQTKQKTKKR 693
                 57999999*******************************.66666666654 PP

>> KfrA_N  Plasmid replication region DNA-binding N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.6         5   1.8e+04      72      93 ..     457     483 ..     453     486 .. 0.56
   2 ?    0.9   0.0       0.2   7.1e+02      11      62 ..     541     598 ..     535     621 .. 0.73
   3 ?    9.4   0.9   0.00046       1.7      58     106 ..     639     686 ..     631     694 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 5
      KfrA_N  72 wqaaleeaee.....elaaaraelqaa 93 
                 wq +++  ++     +la++r+ lq+ 
  EFC36526.1 457 WQLLHDSEKQhyielALASQREMLQQV 483
                 555555555555555566666666654 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.2
      KfrA_N  11 allaeGerpTveavrerlGgGspntisrvlkeweaelaaalaaraa.......pelPea 62 
                 +l + ++++T+++v + l +G ++ ++ v+ ++++   + +++++        +++Pe+
  EFC36526.1 541 SLKELDKNVTANRVKKPL-SGYNSFVKSVFPSFQEMYPNIDKKQITkligqkwKAMPED 598
                 67788899*********9.9999999999999988777766666555555555555555 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00046
      KfrA_N  58 elPealaeallaalwqaaleeaeeelaaaraelqaaraaleaeraeaea 106
                   P ++ + + a  w++a++e ++++  + ++++++ +++ +++ e + 
  EFC36526.1 639 LAPNEVSRMV-ASSWKKAKKEEKQKYYDLAEKWKQESEEMISTAVEKQT 686
                 4699999999.***************************99887755444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (695 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1612  (0.0899102); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.81u 0.31s 00:00:01.12 Elapsed: 00:00:00.56
# Mc/sec: 3715.57
//
Query:       EFC36527.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00056   19.3   0.0    0.00061   19.1   0.0    1.3  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   3.4e-08   0.00061     232     259 .]      90     117 ..      40     117 .. 0.84

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 3.4e-08
                  HHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 232 eelyelmkkcweedpeeRptfselvekl 259
                  e + +lm+kcw++dp+ Rp+fse+ ++l
   EFC36527.1  90 ELFVSLMEKCWSQDPSGRPKFSEIFNDL 117
                  456789******************8876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       709  (0.0395449); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.51
# Mc/sec: 748.12
//
Query:       EFC36528.1  [L=753]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.7e-29  100.8   0.1    7.1e-28   97.7   0.1    2.1  1  Pkinase      Protein kinase domain
    5.4e-28   98.0   0.1    2.5e-26   92.5   0.1    2.1  1  Pkinase_Tyr  Protein tyrosine kinase
     0.0013   18.5   1.9     0.0026   17.5   1.9    1.4  1  LapA_dom     Lipopolysaccharide assembly protein A domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.7   0.1   1.2e-31   7.1e-28       2     145 ..     579     744 ..     578     750 .. 0.89

  Alignments for each domain:
  == domain 1  score: 97.7 bits;  conditional E-value: 1.2e-31
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS- CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsl 95 
                 + ++k+GeG++G+++ a+  ++   vA+K + +++++++++ +++ rE+++l +l+ p+iv++y+v+ +++++++v+ey+e g+l+++++     k  l
  EFC36528.1 579 KIEKKIGEGAYGSIFLAK-CWETTNVAIKSFHQKSEENETNgEDFEREVSLLVNLRNPYIVTFYGVCITESKRFMVVEYCERGSLEKIINdcrsGKDFL 676
                 5689*************9.699999******99999999889************************************************996656669 PP

                 -HHHHHHHHHHHHHHHHHHHHTT..................EE-SS-SGGGEEEETTTEEEE-SGTTS CS
     Pkinase  96 seeeakkiakqilegleylHskg..................iiHrDlKpeNiLidekgelKitDFGla 145
                 + ++  +i+  i +g++ylH  +                   + rDlKp+N+Li+ +g+ K++DFG++
  EFC36528.1 677 TLSQKAQILLDISSGMKYLHGLKpklihrlvftvsivllidNLLRDLKPANVLINATGQAKVCDFGVC 744
                 999*****************7777777777666665544333568*********************98 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.5   0.1   4.2e-30   2.5e-26       1     150 [.     578     744 ..     578     750 .. 0.85

  Alignments for each domain:
  == domain 1  score: 92.5 bits;  conditional E-value: 4.2e-30
                  EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH..HHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT. CS
  Pkinase_Tyr   1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateee..keelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk. 95 
                  l+++kk+GeGa+G+++ +++      ++++Va+K+++++++e+e   e++ +e++++ +l++p iv ++gvc+ e++ ++v+ey++ G+L+k +++  
   EFC36528.1 578 LKIEKKIGEGAYGSIFLAKCW-----ETTNVAIKSFHQKSEENEtnGEDFEREVSLLVNLRNPYIVTFYGVCITESKRFMVVEYCERGSLEKIINDCr 670
                  6899****************9.....899*******777666653379**********************************************9874 PP

                  .CTTTSBHHHHHHHHHHHHHHHHHHHHTT..EEES................T-SGGGEEEEETTEEEE-STTTH CS
  Pkinase_Tyr  96 .ekekltlkdllsfalqvAkGmeyLeskk..lvHr................dlaarNvLlsenkvvkisDfGLa 150
                    k+ ltl+++ ++ l++++Gm+yL+  k  l+Hr                dl   NvL++ + ++k++DfG++
   EFC36528.1 671 sGKDFLTLSQKAQILLDISSGMKYLHGLKpkLIHRlvftvsivllidnllrDLKPANVLINATGQAKVCDFGVC 744
                  45788*********************654449**6444444444444444488888888888**********87 PP

>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   1.9   4.4e-07    0.0026      23      62 ..     498     535 ..     491     537 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 4.4e-07
    LapA_dom  23 llvafgiGallgwllslwsylrlrrelrrlkkkikkleke 62 
                 +l+a++ G+++g+l+++   +r+ ++++ + kk+kklek 
  EFC36528.1 498 VLLALISGIIIGLLITFA--FRKLWKIKDKLKKLKKLEKA 535
                 6899999*********97..9*****************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (753 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       830  (0.0462937); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.79u 0.34s 00:00:01.13 Elapsed: 00:00:00.52
# Mc/sec: 4319.89
//
Query:       EFC36529.1  [L=377]
Description: hypothetical protein NAEGRDRAFT_82840 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   5.3e-149  496.3   0.0   2.1e-148  494.3   0.0    1.7  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  494.3   0.0  1.2e-152  2.1e-148       2     407 .]       5     377 .]       4     377 .] 0.98

  Alignments for each domain:
  == domain 1  score: 494.3 bits;  conditional E-value: 1.2e-152
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 ++v+a+V+DnGs++++aG+ag+daP+av+ps++g+p++++ +      + yvgdea++kr+ l++++p+e+G+v++wd++e++w+h++++el+v peeh
  EFC36529.1   5 EDVQALVVDNGSGMCKAGFAGDDAPRAVFPSIIGRPKQKSIMVgmgnkDAYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH 103
                 689************************************998899**9*************************************************** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvev 194
                 p+llte+plnp+++rek+++i+fE+f vpa+y+a +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G++Lt++l+++l ++    
  EFC36529.1 104 PVLLTEAPLNPKANREKMTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMER---- 198
                 **********************************************************************************************8.... PP

       Actin 195 tprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligs 291
                                           ++s++t++e+e++++iKe++c+++ d+e+  + +++sss eksYeLPDg++i++g+eRf++pE+LF+p+ ig+
  EFC36529.1 199 --------------------------GYSFNTTAEREIVRDIKEKLCYIALDFEAemKVAAESSSVEKSYELPDGNVITVGNERFRCPEVLFQPNFIGM 271
                 ..........................9**************************996666677799********************************** PP

       Actin 292 esaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvs 390
                 e a         g++e ++++i +cd+d+r++L+ n+v++GG+++++g+ eR+ kel+++a++++k+k++ap+ erkys+WiGGSiLAsl+tfqq+w++
  EFC36529.1 272 EAA---------GVHETTFNSIGKCDIDIRKDLYGNVVLSGGTTMFEGIAERMTKELTAMAPASMKIKVVAPP-ERKYSVWIGGSILASLSTFQQMWIT 360
                 *99.........*************************************************************.************************* PP

       Actin 391 kqEYeEqGssvverkck 407
                 k+EYe+ G+ +v+rkc+
  EFC36529.1 361 KEEYEDAGPGIVHRKCF 377
                 ****************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       349  (0.0194657); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 2269.86
//
Query:       EFC36530.1  [L=680]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-05   24.1  37.4     0.0057   17.0   4.5    7.4  7  LRR_4     Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
       0.04   14.0  11.7        9.3    6.6   1.1    6.3  6  LRR_6     Leucine Rich repeat
       0.15   11.8  11.9      0.023   14.5   4.4    3.2  3  FTH       FTH domain


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.5    0.0049        29      21      39 ..     229     243 ..     218     261 .. 0.59
   2 ?   -1.0   0.1      0.46   2.7e+03      19      29 ..     316     325 ..     297     344 .. 0.63
   3 !   17.0   4.5   9.6e-07    0.0057       2      39 ..     357     397 ..     357     405 .. 0.87
   4 ?    1.1   0.4     0.098   5.9e+02       2      29 ..     408     438 ..     406     450 .. 0.64
   5 !    9.2   0.3   0.00028       1.6      18      41 ..     480     501 ..     472     506 .. 0.71
   6 !    4.6   0.2    0.0077        46       8      36 ..     548     579 ..     541     585 .. 0.66
   7 !    6.9   0.1    0.0015       8.8       3      32 ..     594     626 ..     594     633 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0049
                 H-TT--EEE-.-S-----G CS
       LRR_4  21 klpnLkeLdLsgNnlitdl 39 
                 ++p+L+ L + gN    ++
  EFC36530.1 229 NCPKLEILKIDGN----SF 243
                 4777777777666....22 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.46
                 HHH-TT--EEE CS
       LRR_4  19 leklpnLkeLd 29 
                 l  l++L+ L+
  EFC36530.1 316 LT-LKSLQDLS 325
                 44.66666664 PP

  == domain 3  score: 17.0 bits;  conditional E-value: 9.6e-07
                 S--EEE--S.S---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsn.Nqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +L++L L+n N + + ++  l++l+nL++L+L+++ +++d 
  EFC36530.1 357 SLKTLELFNeNSIESNGFkkLGSLKNLTHLNLTRCDNLDDM 397
                 69******66********99999*********998667665 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.098
                 S--EEE--SS.---E-S-..HHH-TT--EEE CS
       LRR_4   2 nLevLdLsnN.qltdipl..leklpnLkeLd 29 
                 + ++L L n+ q+++ +l  +++l +L +Ld
  EFC36530.1 408 SVKKLILDNCwQVSEESLkeISNLSDLYHLD 438
                 6789999999888865553322355554444 PP

  == domain 5  score: 9.2 bits;  conditional E-value: 0.00028
                 -.HHH-TT--EEE-.-S-----GGG CS
       LRR_4  18 l.leklpnLkeLdLsgNnlitdlde 41 
                   lek+p+Lk+L+L  N + ++l++
  EFC36530.1 480 IlLEKFPSLKYLNL--N-RWEKLTD 501
                 34789*********..5.5555543 PP

  == domain 6  score: 4.6 bits;  conditional E-value: 0.0077
                 --SS---E-S-....HH.H-TT--EEE-.-S--- CS
       LRR_4   8 LsnNqltdipl....le.klpnLkeLdLsgNnli 36 
                 L++  + di+     l+ + p L+eL++sgN ++
  EFC36530.1 548 LQS--VDDINQamtvLSeSTPLLEELSVSGNENL 579
                 555..55555555553326899********9444 PP

  == domain 7  score: 6.9 bits;  conditional E-value: 0.0015
                 --EEE--SS---E-S-HH..H.-TT--EEE-.- CS
       LRR_4   3 LevLdLsnNqltdiplle..k.lpnLkeLdLsg 32 
                 L+v+d+s++ l + + l+  + l+nL+e+++ +
  EFC36530.1 594 LRVIDFSQCSLLSDEALNavSiLKNLREINIVE 626
                 899*****97665555777888********955 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0     0.068     4e+02       1      18 [.     229     246 ..     229     246 .. 0.90
   2 ?    6.6   1.1    0.0016       9.3       3      17 ..     381     396 ..     379     402 .. 0.88
   3 ?   -3.4   0.0       2.5   1.5e+04       2      16 ..     406     421 ..     405     428 .. 0.70
   4 ?   -0.0   0.0       0.2   1.2e+03       3      12 ..     486     495 ..     486     508 .. 0.74
   5 ?    5.7   0.1     0.003        18       5      21 ..     568     585 ..     564     588 .. 0.86
   6 ?    0.7   0.0      0.12     7e+02       2      20 ..     591     610 ..     590     614 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.068
       LRR_6   1 snthLteLdLsgNdIgDe 18 
                 ++++L+ L + gN ++ e
  EFC36530.1 229 NCPKLEILKIDGNSFTTE 246
                 699**********99876 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0016
       LRR_6   3 thLteLdLsgNd.IgD 17 
                  +Lt+L+L+ +d ++D
  EFC36530.1 381 KNLTHLNLTRCDnLDD 396
                 58**********9988 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 2.5
       LRR_6   2 nthLteLdLsgNd.Ig 16 
                 + ++++L L  +  ++
  EFC36530.1 406 CKSVKKLILDNCWqVS 421
                 7789999998886555 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 0.2
       LRR_6   3 thLteLdLsg 12 
                 ++L++L+L+ 
  EFC36530.1 486 PSLKYLNLNR 495
                 589****975 PP

  == domain 5  score: 5.7 bits;  conditional E-value: 0.003
       LRR_6   5 LteLdLsgNd.IgDeGae 21 
                 L+eL++sgN+ ++D+ +e
  EFC36530.1 568 LEELSVSGNEnLNDDAVE 585
                 99************9876 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.12
       LRR_6   2 nthLteLdLsgNd.IgDeGa 20 
                 + +L+  d s +  ++De +
  EFC36530.1 591 CKYLRVIDFSQCSlLSDEAL 610
                 789**********9999865 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1      0.53   3.2e+03      31      60 ..     222     252 ..     203     261 .. 0.56
   2 ?   14.5   4.4   3.8e-06     0.023      42     134 ..     381     476 ..     316     483 .. 0.86
   3 ?   -0.1   0.1      0.13   7.5e+02       7      52 ..     583     629 ..     577     664 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.53
         FTH  31 dvasiLssfkagtLeeIel...sseeeeeefee 60 
                  + si +++    Le +++   s++ ee +f++
  EFC36530.1 222 VLSSIVKNCPK--LEILKIdgnSFTTEEVQFNN 252
                 44444444443..44444444544444445544 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 3.8e-06
         FTH  42 gtLeeIelsseeeeeefeelveleQWKnAkklkiessklssf....piehlfhFeefeikldkfsvedaikirdillksstFqsceileskdtnsie 134
                 ++L +++l+  ++ +++   + l   K+ kkl ++++  +s+    +i +l+ + +++++  +++ + ++ i d++ ++++F ++++ es+ + ++e
  EFC36530.1 381 KNLTHLNLTRCDNLDDMALSTILRKCKSVKKLILDNCWQVSEeslkEISNLSDLYHLDTTGLRITNKVLKVIADSVSSNEKFTHFIC-ESNYNATDE 476
                 46889999*************************88877766556679****************************************.777776666 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.13
         FTH   7 lkkilks.kkclkvkklsleglsfkdvasiLssfkagtLeeIel..sse 52 
                   +il +  k l v  +s   l  ++++++ s++k   L+eI++  ++e
  EFC36530.1 583 AVEILCEgCKYLRVIDFSQCSLLSDEALNAVSILKN--LREINIveCEE 629
                 556666656666666677667777899999999987..99999944333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (680 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1419  (0.0791455); expected 358.6 (0.02)
Passed bias filter:                      630  (0.0351386); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.37s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 3883.20
//
Query:       EFC36531.1  [L=289]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-26   92.0   8.0    6.6e-05   22.6   0.0    5.7  6  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.049   13.8   0.8       0.45   10.7   0.0    2.6  3  RPN13_C   UCH-binding domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.1   1.4e-08   0.00013      13      48 ..       3      38 ..       2      39 .. 0.91
   2 !   22.6   0.0   7.3e-09   6.6e-05       2      35 ..      42      75 ..      41      92 .. 0.88
   3 !   22.1   0.0     1e-08     9e-05       2      48 ..     118     163 ..     117     164 .. 0.91
   4 !   15.4   0.7   1.3e-06     0.011       3      47 ..     167     221 ..     165     224 .. 0.76
   5 !   10.9   0.0   3.3e-05      0.29       3      49 .]     221     270 ..     219     270 .. 0.89
   6 !    7.3   0.0   0.00044       3.9       6      35 ..     252     281 ..     248     284 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 1.4e-08
     DUF4116 13 gsalkylseeLknDkeivlkAvkqngtalsyaseeL 48
                +++++y+se+ ++Dke +l++++ +++ + +++ +L
  EFC36531.1  3 PKSYEYASERVRSDKEMALRILELHPSLYVHFHSSL 38
                679************************998888776 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 7.3e-09
     DUF4116  2 rEivleavkkngsalkylseeLknDkeivlkAvk 35
                r+i +++++ n+ +++ l++ +k Dke++  A++
  EFC36531.1 42 RDIQMKIIQFNPTHYYCLPKGFKYDKEFIVNALN 75
                9*******************************98 PP

  == domain 3  score: 22.1 bits;  conditional E-value: 1e-08
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 r+ +l++vk +g  + +++ ++  D ei++ A+kq ++al+++++++
  EFC36531.1 118 RDQILQCVKADGTTIGFFD-DYMEDVEILKCALKQTPFALEFIPKKY 163
                 6779***************.5667********************976 PP

  == domain 4  score: 15.4 bits;  conditional E-value: 1.3e-06
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngt...........alsyasee 47 
                 +i+le++++++ +lk+++ e+k+  + v++ v ++++           ++ y see
  EFC36531.1 167 DIILELLEIYPDILKHIPTEFKK-LDCVIETVIRSPNfkahtishlpdNYTYSSEE 221
                 8********************95.67777777777766777666666666666666 PP

  == domain 5  score: 10.9 bits;  conditional E-value: 3.3e-05
     DUF4116   3 Eivlea.vkkngsalkylsee..LknDkeivlkAvkqngtalsyaseeLr 49 
                 Ei l + +k+n +a+ ++s+   L+  k  ++ +++ ng++++ +++ L+
  EFC36531.1 221 EILLTLlLKSNANAIMKISPTqlLTLPKSNIISCLRLNGKIFPDLPPQLQ 270
                 66666659999********88889**********************9986 PP

  == domain 6  score: 7.3 bits;  conditional E-value: 0.00044
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvk 35 
                   +++ ng+++  l++ L++D  +++ A+k
  EFC36531.1 252 ISCLRLNGKIFPDLPPQLQQDPHLLKTAIK 281
                 678899999999999999999999999998 PP

>> RPN13_C  UCH-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       0.7   6.3e+03      19      48 ..      24      53 ..      13      56 .. 0.75
   2 ?   10.7   0.0     5e-05      0.45      28      69 ..     164     205 ..     146     211 .. 0.84
   3 ?   -0.0   0.1      0.11   9.6e+02      36      62 ..     254     280 ..     221     283 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.7
     RPN13_C 19 vsLsdiltpealspllsdpevveeLashLP 48
                ++L+  l     s+lls+ +++ +++++ P
  EFC36531.1 24 LELHPSLYVHFHSSLLSHRDIQMKIIQFNP 53
                567777777788889999998888888766 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 5e-05
     RPN13_C  28 ealspllsdpevveeLashLPeegeateeelretlrSPqfrq 69 
                 ++l+ +l+  e+  ++++h+P+e ++    +++++rSP+f++
  EFC36531.1 164 QTLDIILELLEIYPDILKHIPTEFKKLDCVIETVIRSPNFKA 205
                 566677799999**********999999************96 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.11
     RPN13_C  36 dpevveeLashLPeegeateeelretl 62 
                    +  ++++ LP++ ++++  l++ +
  EFC36531.1 254 CLRLNGKIFPDLPPQLQQDPHLLKTAI 280
                 444556778888887777777766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (289 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       389  (0.0216967); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.24s 00:00:00.68 Elapsed: 00:00:00.42
# Mc/sec: 2068.31
//
Query:       EFC36532.1  [L=410]
Description: hypothetical protein NAEGRDRAFT_82195 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0047   16.2   1.6      0.008   15.4   0.5    1.9  2  DndB            DNA-sulfur modification-associated
     0.0068   16.1   5.4       0.76    9.5   0.2    3.9  4  Dsl1_C          Retrograde transport protein Dsl1 C terminal
      0.008   16.4   0.0        6.2    7.1   0.0    4.0  5  Plasmid_RAQPRD  Plasmid protein of unknown function (Plasmid_
  ------ inclusion threshold ------
      0.012   15.3   2.7       0.27   10.8   0.1    3.4  2  Pex2_Pex12      Pex2 / Pex12 amino terminal region
       0.39   11.4   3.2        3.1    8.6   0.1    3.3  3  COMPASS-Shg1    COMPASS (Complex proteins associated with Set
        0.8    9.7  10.3        4.4    7.3   0.2    5.3  6  IBN_N           Importin-beta N-terminal domain
        1.6    8.7   5.6        1.6    8.8   0.1    3.8  5  Taeniidae_ag    Taeniidae antigen
        3.3    6.9   7.4        1.6    7.9   0.8    2.9  3  MKT1_C          Temperature dependent protein affecting M2 ds


Domain annotation for each model (and alignments):
>> DndB  DNA-sulfur modification-associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.1   2.5e+03     271     293 ..      87     110 ..      76     119 .. 0.84
   2 !   15.4   0.5   3.6e-06     0.008     176     246 ..     154     227 ..     130     248 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.1
        DndB 271 glqalgrllkallkek.pddwket 293
                 +l+ +g+++ka +k + +++w e 
  EFC36532.1  87 ALKVVGEIGKAAIKDYvNKNWDEI 110
                 588999999999999988888875 PP

  == domain 2  score: 15.4 bits;  conditional E-value: 3.6e-06
        DndB 176 klleevpifa..glvemeksslskkseklfTlstlveatkellkn..qsaskealdekielasefwnavaetipe 246
                 ++++ + +++  g+++ + ++  ++++k f +s++ +++k + kn  ++  +++ de++el+++fw +v +++++
  EFC36532.1 154 EVIKTILPYIkaGVKNYIANNFDEEADKKF-FSSIWKVVKDIGKNaaKDYVNQNWDEEMELSDKFWGKVWKVVKD 227
                 5555555544579*****************.**************999999******************999877 PP

>> Dsl1_C  Retrograde transport protein Dsl1 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.035        78      20      62 ..      96     138 ..      85     148 .. 0.85
   2 !    9.5   0.2   0.00034      0.76      38      77 ..     147     187 ..     136     197 .. 0.71
   3 ?   -0.3   0.0      0.33   7.4e+02      36      65 ..     245     274 ..     211     291 .. 0.71
   4 ?    3.4   0.1     0.024        54      18      70 ..     337     389 ..     322     401 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.035
                 HHHHHHHHHHHHHHHHHTSSS---HHHHHTHHHHHHHTHHHHH CS
      Dsl1_C  20 kkivkkllqeqlqelkeneknpsWdatiesllPflkkeilnal 62 
                 k ++k  ++++ +e+ e+e + +  +  + +lP+lk+ + + +
  EFC36532.1  96 KAAIKDYVNKNWDEIPEEEADLKLGKLFKAVLPYLKEGAKQYI 138
                 55788899999************************99877655 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00034
                 SSS---HHHHHTHHHHHHHTHHHHHHT.T...--HHHHHHH CS
      Dsl1_C  38 eknpsWdatiesllPflkkeilnalek.lteeedekvllkl 77 
                   + +W + i+ +lP++k  + n + +   ee d+k++ ++
  EFC36532.1 147 MADKKWSEVIKTILPYIKAGVKNYIANnFDEEADKKFFSSI 187
                 35789*****************9887614455555555444 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.33
                 HTSSS---HHHHHTHHHHHHHTHHHHHHTT CS
      Dsl1_C  36 eneknpsWdatiesllPflkkeilnalekl 65 
                 ++ ++ +  +  +++lP++k+ + + +++ 
  EFC36532.1 245 ADAQKLKLGKIWKKVLPYIKSGVKEYINNN 274
                 4555666667789999***99998776654 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.024
                 HHHHHHHHHHHHHHHHHHHTSSS---HHHHHTHHHHHHHTHHHHHHTT...-- CS
      Dsl1_C  18 lkkkivkkllqeqlqelkeneknpsWdatiesllPflkkeilnaleklteeed 70 
                 + k + k+l++ + +  +e + ++++++ +   lP+lk+ +   +++  +ee 
  EFC36532.1 337 TGKEYLKNLVSASAEYQEEADAEIKFKEILRAALPYLKEGVKGYINNNWDEEA 389
                 3466788999999998899999*****************99887776655555 PP

>> Plasmid_RAQPRD  Plasmid protein of unknown function (Plasmid_RAQPRD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       7.7   1.7e+04      54      65 ..      97     108 ..      95     110 .. 0.80
   2 ?   -1.9   0.0       1.8   3.9e+03      52      65 ..     130     143 ..     125     147 .. 0.84
   3 ?   -0.8   0.0      0.83   1.9e+03      51      63 ..     162     174 ..     156     181 .. 0.83
   4 !    7.1   0.0    0.0028       6.2      50      73 ..     261     284 ..     233     286 .. 0.90
   5 ?    3.5   0.0     0.037        83      32      66 ..     355     387 ..     331     392 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 7.7
  Plasmid_RAQPRD  54 aGIqsYLepsRa 65 
                     a I++Y++ +++
      EFC36532.1  97 AAIKDYVNKNWD 108
                     679999998875 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.8
  Plasmid_RAQPRD  52 iraGIqsYLepsRa 65 
                     +++G ++Y++++++
      EFC36532.1 130 LKEGAKQYINNNWD 143
                     68999*****9985 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.83
  Plasmid_RAQPRD  51 riraGIqsYLeps 63 
                      i+aG+++Y++++
      EFC36532.1 162 YIKAGVKNYIANN 174
                     699******9986 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0028
  Plasmid_RAQPRD  50 eriraGIqsYLepsRaqprdpspL 73 
                       i++G+++Y++++++q  ++s L
      EFC36532.1 261 PYIKSGVKEYINNNWDQNEEMSDL 284
                     579**************9999887 PP

  == domain 5  score: 3.5 bits;  conditional E-value: 0.037
  Plasmid_RAQPRD  32 qeekaRvhfdYdrlrrDleriraGIqsYLepsRaq 66 
                     ++  a ++f  + lr+ l  +++G++ Y+++++++
      EFC36532.1 355 EA-DAEIKFK-EILRAALPYLKEGVKGYINNNWDE 387
                     33.3446665.568999999***********9976 PP

>> Pex2_Pex12  Pex2 / Pex12 amino terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   0.00012      0.27      84     142 ..     122     168 ..     114     176 .. 0.84
   2 ?    2.0   0.4     0.057   1.3e+02      85      85 ..     327     327 ..     246     407 .. 0.55

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00012
  Pex2_Pex12  84 lllvlipYlkekldelysarerysaealsdearnsreslkkrlkrlllklypfiealye 142
                 l+++++pYlke + +++            +++ +++e + k++ + ++ ++p+i+a+ +
  EFC36532.1 122 LFKAVLPYLKEGAKQYI------------NNNWDAEEMADKKWSEVIKTILPYIKAGVK 168
                 6889*************............256778888999************999755 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.057
  Pex2_Pex12  85 l 85 
                  
  EFC36532.1 327 W 327
                 0 PP

>> COMPASS-Shg1  COMPASS (Complex proteins associated with Set1p) component shg1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.5   3.3e+03      42      42 ..      70      70 ..      22     160 .. 0.61
   2 ?    1.5   0.3      0.22     5e+02      42      88 ..     231     276 ..     130     295 .. 0.63
   3 ?    8.6   0.1    0.0014       3.1      25      89 ..     315     388 ..     312     398 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.5
  COMPASS-Shg1 42 s 42
                  +
    EFC36532.1 70 N 70
                  1 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.22
  COMPASS-Shg1  42 sevkkdpsllfknrgkaaaliegeidrsdvykkleegvdrivdqdlq 88 
                     vk+  +  f   + a++l  g+i + +v+  +++gv+++++++ +
    EFC36532.1 231 GAVKSYVNQNFDSAADAQKLKLGKIWK-KVLPYIKSGVKEYINNNWD 276
                   333333344444444444444444555.4555555666666666655 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0014
  COMPASS-Shg1  25 eseaeqnlrkkveeivesevkkdpsllfknrgkaaaliegeidrsdvykkle........egvdrivdqdlq.e 89 
                   +++++++++kk+ ++v++e+kk  +  +kn  +a+a+ ++e d + + k++         egv+ +++++ + e
    EFC36532.1 315 DMPQSDKFLKKIWKVVRDELKKTGKEYLKNLVSASAEYQEEADAEIKFKEILraalpylkEGVKGYINNNWDeE 388
                   6678899*****************999999**********9999855553334445666699999999988732 PP

>> IBN_N  Importin-beta N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0         3   6.7e+03      37      46 ..      35      44 ..      29      66 .. 0.74
   2 ?    2.6   0.0     0.057   1.3e+02      39      61 ..      99     115 ..      95     117 .. 0.88
   3 ?    7.3   0.2     0.002       4.4      40      71 ..     135     174 ..     134     177 .. 0.83
   4 ?    0.6   0.1      0.24   5.4e+02      40      51 ..     268     279 ..     234     290 .. 0.77
   5 ?   -0.5   0.1      0.54   1.2e+03      38      46 ..     341     349 ..     319     383 .. 0.66
   6 ?   -0.4   0.1      0.48   1.1e+03      40      52 ..     378     390 ..     363     402 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3
                HHHHHHHHHH CS
       IBN_N 37 lyLknlitkh 46
                + +kn++++ 
  EFC36532.1 35 IFFKNFLKQQ 44
                6788888876 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.057
                 HHHHHHHHGGSCCCHCGSXHHHH CS
       IBN_N  39 LknlitkhWsdeeekqslpseek 61 
                 +k +++k+W       ++p+ee 
  EFC36532.1  99 IKDYVNKNWD------EIPEEEA 115
                 6899******......****996 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.002
                 HHHHHHHGGSCCCHC........GSXHHHHHHHHHHHHHH CS
       IBN_N  40 knlitkhWsdeeekq........slpseekeqIrnnllnl 71 
                 k++i+++W  ee +         ++ + +k+ ++n++ n 
  EFC36532.1 135 KQYINNNWDAEEMADkkwsevikTILPYIKAGVKNYIANN 174
                 8999****955555467899999**************986 PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.24
                 HHHHHHHGGSCC CS
       IBN_N  40 knlitkhWsdee 51 
                 k +i+++W ++e
  EFC36532.1 268 KEYINNNWDQNE 279
                 567777777555 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 0.54
                 HHHHHHHHH CS
       IBN_N  38 yLknlitkh 46 
                 yLknl++++
  EFC36532.1 341 YLKNLVSAS 349
                 455555554 PP

  == domain 6  score: -0.4 bits;  conditional E-value: 0.48
                 HHHHHHHGGSCCC CS
       IBN_N  40 knlitkhWsdeee 52 
                 k +i+++W +e++
  EFC36532.1 378 KGYINNNWDEEAD 390
                 5689999995554 PP

>> Taeniidae_ag  Taeniidae antigen
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.1   2.5e+03      51      60 ..      96     105 ..      85     109 .. 0.76
   2 ?   -3.0   0.0       3.4   7.6e+03      41      58 ..     186     203 ..     181     205 .. 0.63
   3 ?   -2.7   0.0       2.7   6.2e+03      42      59 ..     221     238 ..     219     239 .. 0.70
   4 ?   -1.4   0.0       1.1   2.4e+03      39      59 ..     252     272 ..     249     274 .. 0.81
   5 ?    8.8   0.1    0.0007       1.6      39      62 ..     323     346 ..     317     348 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.1
  Taeniidae_ag  51 reaLkeYvkk 60 
                   ++a+k+Yv k
    EFC36532.1  96 KAAIKDYVNK 105
                   7899999976 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 3.4
  Taeniidae_ag  41 aicqklrkKvreaLkeYv 58 
                   +i + ++   ++a k+Yv
    EFC36532.1 186 SIWKVVKDIGKNAAKDYV 203
                   455666666667777777 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 2.7
  Taeniidae_ag  42 icqklrkKvreaLkeYvk 59 
                   + + ++   + a+k+Yv 
    EFC36532.1 221 VWKVVKDIGKGAVKSYVN 238
                   556666666888999985 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 1.1
  Taeniidae_ag  39 ltaicqklrkKvreaLkeYvk 59 
                   l++i +k+   +++ +keY+ 
    EFC36532.1 252 LGKIWKKVLPYIKSGVKEYIN 272
                   567888888889999999986 PP

  == domain 5  score: 8.8 bits;  conditional E-value: 0.0007
  Taeniidae_ag  39 ltaicqklrkKvreaLkeYvkkLv 62 
                   l++i + +r  +++  keY+k+Lv
    EFC36532.1 323 LKKIWKVVRDELKKTGKEYLKNLV 346
                   78999******************9 PP

>> MKT1_C  Temperature dependent protein affecting M2 dsRNA replication
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.2     0.055   1.2e+02     205     233 ..      82     109 ..      27     113 .. 0.84
   2 ?    7.9   0.8    0.0007       1.6     192     236 ..     202     246 ..     144     249 .. 0.78
   3 ?   -2.1   0.0      0.79   1.8e+03     203     229 ..     319     343 ..     297     375 .. 0.56

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.055
      MKT1_C 205 efwdavyalvkelseekliskellkefek 233
                 +fw++ +++v e+++ ++i++ + k +++
  EFC36532.1  82 SFWKKALKVVGEIGK-AAIKDYVNKNWDE 109
                 69***********98.9999999999987 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0007
      MKT1_C 192 n.vedlkedlerafefwdavyalvkelseekliskellkefekade 236
                 +  ++ +e++e + +fw +v ++vk++++  ++++ + + f+ a +
  EFC36532.1 202 YvNQNWDEEMELSDKFWGKVWKVVKDIGK-GAVKSYVNQNFDSAAD 246
                 3468999*********************8.9999999999999865 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.79
      MKT1_C 203 afefwdavyalvkelseekliskellk 229
                 + +f++++ ++v++  +  +  ke lk
  EFC36532.1 319 SDKFLKKIWKVVRDELK--KTGKEYLK 343
                 55555555555544322..22222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1224  (0.0682693); expected 358.6 (0.02)
Passed bias filter:                      668  (0.0372581); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.43
# Mc/sec: 2857.25
//
Query:       EFC36533.1  [L=613]
Description: rho GTPase activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-29  103.2   0.2    1.1e-29  103.2   0.2    2.6  2  RhoGAP      RhoGAP domain
  ------ inclusion threshold ------
      0.045   13.6   2.3      0.061   13.2   1.4    1.6  2  VIT1        VIT family


Domain annotation for each model (and alignments):
>> RhoGAP  RhoGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.2   0.2   1.2e-33   1.1e-29       1     149 [.     266     429 ..     266     433 .. 0.92
   2 ?   -4.9   5.4         2   1.8e+04      46      94 ..     506     560 ..     446     575 .. 0.57

  Alignments for each domain:
  == domain 1  score: 103.2 bits;  conditional E-value: 1.2e-33
                 BHHHHHHHHHHHH.HTTTSTTTTTS-S-HHHHHHHHHHHHHTGGGCT........TTTTSCHHHHHHHHHHHHHHSSSTTTTGGHHHHHHHHHTSSSHH CS
      RhoGAP   1 Piivekcvefiek.rgldtegiyRvsgskarvkelreafdkgkavds........dleeedvhavaslLKrfLrelpepLltkelyeelieaaksedee 90 
                 P i++ c+++++  +g++t gi+R  gsk+rv el++ f++  a  +          +++ v +va+l+K+++r+lpe Llt++ yee+ie+   +++e
  EFC36533.1 266 PYILRVCLKYLRDnKGVKTLGIFREAGSKRRVLELCKLFNSFMAFPEmyndlaieIPQSFGVMVVADLIKHYIRNLPECLLTFDKYEEVIEMFTGRTPE 364
                 89**********9788***************************999999****99999********************************976665555 PP

                 HH...HHHHHHHHTTS-HHHHHHHHHHHHHHHHHHHTHHH...H---HHHHHHHHHHHHHT-TSS CS
      RhoGAP  91 er...lealkellekLPkenrdtLryLlehLkrvaenske...nkMtaknLaivfaPtLlrpkse 149
                 +    ++++k l+ +LP++n ++L  L+ +L++++ n+++   +kMt+kn++iv++P+Ll  +se
  EFC36533.1 365 KTktlIDKVKLLMIDLPECNKSILSELMNLLHEICCNEENvtlTKMTSKNMGIVIGPNLLYLPSE 429
                 544669999****************************999999*****************98876 PP

  == domain 2  score: -4.9 bits;  conditional E-value: 2
                 T.....TTTTSCHHHHHHHHHH.HHHHSSSTTTTGGHHHHHHHHHTSSSHHHHHH CS
      RhoGAP  46 s.....dleeedvhavaslLKr.fLrelpepLltkelyeelieaaksedeeerle 94 
                       +  +e+ +++++l K+ ++   +e+++ + + e+++ + ++++ ++++e
  EFC36533.1 506 VeqellQKIQEKDQQISQLKKDtYMTLQKEKIIKQLQAENVLLTKENKQLKNQIE 560
                 1333332222333334444442244444555555555555554444444444444 PP

>> VIT1  VIT family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.48   4.3e+03      45      67 ..      58      80 ..      57     103 .. 0.85
   2 ?   13.2   1.4   6.8e-06     0.061      67     160 ..     491     609 ..     479     613 .] 0.45

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.48
        VIT1 45 aiSMgiGeYlsvkserdlekaer 67
                +iS  + eY s+ s++ lek+++
  EFC36533.1 58 SISKIFSEYASTFSQSPLEKEQQ 80
                68888999*******99998765 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 6.8e-06
        VIT1  67 rkreeeeleedpe.egeaeelaeilear...............................glseelaqevaaellknpdallelmlreelgpsaseel.. 131
                 +k+++++ +++++ e+e+e l++i e+                                + +++l+++ ++el k++++++e+        +++e    
  EFC36533.1 491 VKSNKKQQDTTSNsEVEQELLQKIQEKDqqisqlkkdtymtlqkekiikqlqaenvlltKENKQLKNQ-IEELNKEEEQVEET-------QENEE-Vtt 580
                 33333333444444555333344444333333333333333333333332222222211111111111.22222222222111.......11122.234 PP

        VIT1 132 asplkaAlssalsfliGgliPllpylfve 160
                  +p ++ +s + sfli ++i ++ y+ ++
  EFC36533.1 581 SEPESSSISWMSSFLIISTIGMILYFYFP 609
                 68999********************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (613 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3702  (0.206481); expected 358.6 (0.02)
Passed bias filter:                      651  (0.0363099); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.32s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 3437.62
//
Query:       EFC36534.1  [L=669]
Description: subtilisin-like serine protease [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-49  167.1   4.5    2.2e-48  165.1   3.6    2.0  2  Peptidase_S8   Subtilase family
  ------ inclusion threshold ------
      0.022   14.7   0.1      0.059   13.3   0.1    1.6  1  SWIRM-assoc_1  SWIRM-associated region 1
        1.2    9.3   5.7        3.1    8.0   0.5    3.0  3  DUF2615        Protein of unknown function (DUF2615)
        1.2    9.5  21.6        1.9    8.9   2.1    2.8  2  EGF_2          EGF-like domain


Domain annotation for each model (and alignments):
>> Peptidase_S8  Subtilase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0     0.069   3.1e+02     175     219 ..     175     254 ..     166     259 .. 0.89
   2 !  165.1   3.6   4.9e-52   2.2e-48       1     298 []     264     537 ..     264     537 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.069
                   TTCEECTTTSTTCEEEEEES...................................TTSSB-TT--B-TT.......-EEE CS
                   xxxxxxxxxxxxxxxxxxxx...................................xxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_S8 175 gspvgtpstsknvitvgayt...................................tegkiapfSsrGpssdgklkpdiva 219
                    +++g+ s++ n+itv+ +t                                   +  ++a+ Ss+G +++  +++ +va
    EFC36534.1 175 DQKIGARSNWLNAITVSDVTqeqiekiqklafvdriervatfkrsnleernqkvvNTRHVADDSSYGVAFNQLNQVNVVA 254
                   56777888777*********9999999999999999999999999999999999999999999****9999999999988 PP

  == domain 2  score: 165.1 bits;  conditional E-value: 4.9e-52
                   -TT-EEEEECS-B-TT-TTTGGGEEE..EEEE---TTSG.GGEETT-SS-TT-SC-SSS....HHHHHHHHHH-B..SSSSSB-SSTTSEEEEEE-S CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_S8   1 gkgvlvavlDtGvdpshpdlsvttdgerklvdvideegagfngadsettstnwarddngnsieHGthvAGiaaanapeegekngvapgakilsvkvl 97 
                   g g+++ v D+G+  +h+ l+          ++  + +++f+++d++t +++ ++    n   HGt + + +a+   + g++ g apga++l +k  
    EFC36534.1 264 GTGITILVCDSGFHLQHKALK----------SIHITGQYDFVNKDTNTDNESGEAATTSN---HGTQCLSAIAGY--DLGNFMGPAPGASVLLAKTE 345
                   789**********99999999..........33445677888888888888877777553...************..9******************* PP

                   STTSB-HH..HHHHHHHHHHHHCT-SEEEE-EE....SCETTCHHCHHHHHH..HHHHHH.CCT-EEEEE--SS-T-HHEEE-TTCEECTTTSTTCE CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_S8  98 dtsggsmetgteliraieeaaedkvdvinmslg....estslpktgrsieal..ainravnkkgvlvviSaGNngktgsslqagspvgtpstsknvi 188
                   d + +++ ++++ i+aie+  + ++d+++ slg     s s++++  +++ l  ++n a   kg ++v +aGN+g  g     + ++gtps    vi
    EFC36534.1 346 DVRTETQVEEDNFIEAIEWGERLGADIVSASLGytdwYSHSKKEFNGVTSPLtrVVNIASRYKGLIMVLAAGNEGAGG-----SNTIGTPSDGFDVI 437
                   *******999***********************555544444444444444499999999788************555.....59******999*** PP

                   EEEEESTTSSB-TT--B-TT.......-EEEE-S-..CCCCCCCCCHHHTTTHHEEEE-SHHHCHHHHHHHHHHHHHHHTT--HHHHHHHHHCCS-E CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_S8 189 tvgayttegkiapfSsrGpssdgklkpdivapGgn..ivstwsrqsnnsaglssyqsmsGTSmAsPnaagaaAlllsalpkltpetvraallntAqd 283
                   +vg+++++gki++fSsrGps dg+ kp+++a G++  +vs  +  +        y + sGTS+A+P +ag++Al+l+++p +tp+++r+a+++tA  
    EFC36534.1 438 SVGSVDVNGKISYFSSRGPSDDGRTKPEVSARGSStyLVSPNTDSD--------YLTSSGTSFATPIVAGCVALILQKNPTWTPYQMRKAVMMTA-- 524
                   **********************************965555555555........999**************************************.. PP

                   E......SSSSSSTT CS
                   xxxxxxxxxxxxxxx RF
  Peptidase_S8 284 lgkadniesfaqGaG 298
                    +k+ +   +  G+G
    EFC36534.1 525 -SKN-TEPGNDLGWG 537
                   .444.5566677776 PP

>> SWIRM-assoc_1  SWIRM-associated region 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   1.3e-05     0.059      26      70 ..     190     233 ..     187     243 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.3e-05
  SWIRM-assoc_1  26 vaqlvetqlkKlelKLkqfeelEklleaerrelekqrqqLlleRl 70 
                    v+ +++ q++K++ KL++ +++E++ + +r +le++ q++++ R 
     EFC36534.1 190 VSDVTQEQIEKIQ-KLAFVDRIERVATFKRSNLEERNQKVVNTRH 233
                    8999********8.**************************99885 PP

>> DUF2615  Protein of unknown function (DUF2615)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.5   0.00068       3.1      46      73 ..      26      53 ..      12      72 .. 0.67
   2 ?    2.6   0.0     0.033   1.5e+02      17      40 ..     164     187 ..     160     213 .. 0.72
   3 ?   -2.2   0.1      0.98   4.4e+03       6      12 ..     629     635 ..     625     668 .. 0.53

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00068
     DUF2615 46 peaskeggsslfliallwlvvaavlfll 73
                 ++++++ +s+++++++ ++++a  f+l
  EFC36534.1 26 CQQQQKQYKSSMMMVVVSMMIVATTFVL 53
                3455666667777777777777777766 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.033
     DUF2615  17 amrrLlsllrqsQsyCtDneClde 40 
                  +++++++lrq Q+    ++ l+ 
  EFC36534.1 164 YVQKIVNMLRQDQKIGARSNWLNA 187
                 5799*********98776666655 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.98
     DUF2615   6 DpCeCiw 12 
                 D+C+C++
  EFC36534.1 629 DECQCFY 635
                 4555543 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   2.1   0.00043       1.9      10      24 ..     584     596 ..     573     602 .. 0.76
   2 ?    5.1  11.9    0.0065        29       8      32 .]     621     642 ..     616     642 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00043
       EGF_2  10 ghGtCvnqcGqCdCd 24 
                 ++G+C   +G+C+C 
  EFC36534.1 584 NRGVCF--NGECRCY 596
                 7*****..******4 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0065
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 C+  G+C     +C+C+ g+ G +C
  EFC36534.1 621 CK-SGICS--KDECQCFYGWAGIDC 642
                 76.6***9..436************ PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (669 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1334  (0.0744046); expected 358.6 (0.02)
Passed bias filter:                      700  (0.0390429); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.33s 00:00:01.08 Elapsed: 00:00:00.53
# Mc/sec: 3812.08
//
Query:       EFC36535.1  [L=723]
Description: hypothetical protein NAEGRDRAFT_82197 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (723 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1031  (0.0575046); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.28s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 4471.03
//
Query:       EFC36536.1  [L=402]
Description: nucleoporin SEH1 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-13   51.3  16.3    5.8e-05   23.8   0.1    5.3  5  WD40         WD domain, G-beta repeat
    2.1e-11   43.9   1.6    5.6e-07   29.8   0.3    3.0  3  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    1.2e-05   24.5   0.0      0.066   12.2   0.0    2.7  2  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.3      0.53   3.1e+03       9      33 ..      86     104 ..      77     105 .. 0.79
   2 ?    1.2   0.0      0.13   7.8e+02      13      37 ..     167     193 ..     157     194 .. 0.70
   3 !   11.4   0.2     8e-05      0.48       9      37 ..     212     245 ..     203     246 .. 0.72
   4 !   23.8   0.1   9.8e-09   5.8e-05       5      38 .]     295     333 ..     291     333 .. 0.78
   5 !   22.3   0.4   2.8e-08   0.00017      10      38 .]     352     381 ..     343     381 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.53
                 SS.SSE.EEEEEETTSSEEEEEETTSE CS
        WD40   9 GH.ssv.tslafspdgawlasGsdDgt 33 
                 G  s+v +++        ++ G++D++
  EFC36536.1  86 GNtSPVsNGV--------IVGGGMDHS 104
                 7766788899........998889986 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.13
                 EEEEEEETTSSE..EEEEETTSEEEEE CS
        WD40  13 vtslafspdgaw..lasGsdDgtvriW 37 
                 v +++f p +    la++s  g+vr++
  EFC36536.1 167 VVDIKFAPKHLGlkLATCSLSGKVRVY 193
                 55564444444444799**9*****98 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 8e-05
                 SSSS..EEEEEEETTSSE.........EEEEETTSEEEEE CS
        WD40   9 GHss..vtslafspdgaw.........lasGsdDgtvriW 37 
                 + ++  +++++      w         ++ G++Dg++riW
  EFC36536.1 212 ANNGgkIHCMS------WcpyrfkepmMVIGCEDGKLRIW 245
                 45334699995......5444555888667********** PP

  == domain 4  score: 23.8 bits;  conditional E-value: 9.8e-09
                 EEEESS.SSEEEEEEETTSSE....EEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgaw....lasGsdDgtvriWd 38 
                   l GH ++++++++ p+       +as+s+Dg+vriW+
  EFC36536.1 295 IPLIGHsQPIHDVSWAPNLGRsydlIASASKDGSVRIWK 333
                 5689**888****7555544477768999*********6 PP

  == domain 5  score: 22.3 bits;  conditional E-value: 2.8e-08
                 SSS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  10 Hss.vtslafspdgawlasGsdDgtvriWd 38 
                 H+s v+ + ++ +g+ las++dDg+vr+W+
  EFC36536.1 352 HNSeVWKVEWNLSGTVLASSGDDGSVRLWK 381
                 5446**************999********6 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.027   1.6e+02      49      90 ..     177     224 ..     152     225 .. 0.72
   2 !   11.8   0.0   3.9e-05      0.23      34      70 ..     211     250 ..     197     263 .. 0.81
   3 !   29.8   0.3   9.4e-11   5.6e-07       6      67 ..     316     382 ..     307     393 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.027
  ANAPC4_WD40  49 dgklLavaysdgevrlldaesgkvvhslsvksek......avtclgWg 90 
                   g  La     g+vr+++a +   + ++s++ +       ++ c++W+
   EFC36536.1 177 LGLKLATCSLSGKVRVYEAFDVMNLAHWSIGFDFdannggKIHCMSWC 224
                  466677778889999999888888888777666566667799999995 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 3.9e-05
  ANAPC4_WD40  34 edkedsevrsLaW...kpdgklLavaysdgevrlldaesg 70 
                  ++++++++++++W   + ++ +++++++dg++r+ +  + 
   EFC36536.1 211 DANNGGKIHCMSWcpyRFKEPMMVIGCEDGKLRIWHYTQN 250
                  67999*******9555569***************998765 PP

  == domain 3  score: 29.8 bits;  conditional E-value: 9.4e-11
  ANAPC4_WD40   6 tmDLiAlatedgellvfRlng..qrvwtl....eedkedsevrsLaWkpdgklLavaysdgevrllda 67 
                  + DLiA a++dg++++  ln   +   +l    e++k++sev +++W+ +g++La + +dg+vrl + 
   EFC36536.1 316 SYDLIASASKDGSVRIWKLNSetK-SIELmdidETHKHNSEVWKVEWNLSGTVLASSGDDGSVRLWKY 382
                  57*****************98542.333346698999***************************9764 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   1.1e-05     0.066      60     218 ..     159     336 ..     149     343 .. 0.67
   2 !    9.9   0.0   5.2e-05      0.31     180     226 ..     342     391 ..     330     393 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.1e-05
    Ge1_WD40  60 Llkglkgevldlafahvss.killavdekgslfvykveeveskllvslllkveapietvvsesdrviWCPyipeedaeesdd.deaskllvltrgdkae 156
                  l + +++v+d++fa  +   +l++   +g++ vy+  +v +  + s+ +  +a   +   +++ ++WCPy  +e   +  + d + ++  +t++ k +
  EFC36536.1 159 TLVDSTDDVVDIKFAPKHLgLKLATCSLSGKVRVYEAFDVMNLAHWSIGFDFDA---NNGGKIHCMSWCPYRFKEPMMVIGCeDGKLRIWHYTQNRKWQ 254
                 45677899******976641578899999*******999999888888888887...566788999*****9999887555505556888889999999 PP

    Ge1_WD40 157 iwsvdmiaskygs.gel...sveeieegllkieehsl............iveaafspd.G...talatasedGevkffqvyl 218
                  w  + ++ + ++  +l   ++ ++    + ++e               i + +++p+ G     +a as+dG v+ ++++ 
  EFC36536.1 255 AWIPSQVIPNAQNiSQLvgyTPGSVALKSIVVNEGNItqviplighsqpIHDVSWAPNlGrsyDLIASASKDGSVRIWKLNS 336
                 9976666544433122211122222223333333322345555555556888887776432114689999999999998875 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 5.2e-05
    Ge1_WD40 180 gllkieeh....sliveaafspdGtalatasedGevkffqvyledeeeprC 226
                  l+ i+e+    s++ +  +   Gt+la +  dG v++++ ++e e++ +C
  EFC36536.1 342 ELMDIDEThkhnSEVWKVEWNLSGTVLASSGDDGSVRLWKYNFE-EKKWKC 391
                 55555443111257999999999****************96655.455555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       691  (0.0385409); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.29s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2481.24
//
Query:       EFC36537.1  [L=2218]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   1.1e-173  579.4   7.5   1.6e-173  578.8   7.5    1.3  1  ACC_central      Acetyl-CoA carboxylase, central region
   5.8e-158  526.6   0.1   7.9e-158  526.1   0.1    1.2  1  Carboxyl_trans   Carboxyl transferase domain
    7.1e-50  169.4   0.2    2.3e-49  167.8   0.0    1.9  2  CPSase_L_D2      Carbamoyl-phosphate synthase L chain, ATP bi
    6.8e-29  100.6   0.0    1.7e-28   99.3   0.0    1.7  1  Biotin_carb_N    Biotin carboxylase, N-terminal domain
    2.6e-22   79.0   0.0    8.5e-22   77.3   0.0    2.0  1  Biotin_carb_C    Biotin carboxylase C-terminal domain
    3.5e-11   42.8   0.0    1.4e-10   40.8   0.0    2.1  1  Biotin_lipoyl    Biotin-requiring enzyme
    2.1e-07   31.2   0.2    1.5e-06   28.4   0.0    2.5  2  ATP-grasp_3      ATP-grasp domain
     0.0002   21.0   0.0    0.00068   19.2   0.0    1.9  2  ATP-grasp        ATP-grasp domain
    0.00049   19.9   0.0      0.012   15.4   0.1    2.7  2  Biotin_lipoyl_2  Biotin-lipoyl like
    0.00098   18.7   0.0     0.0032   17.0   0.0    1.9  1  Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
  ------ inclusion threshold ------
      0.056   13.3   0.0       0.65    9.9   0.0    2.6  2  GCV_H            Glycine cleavage H-protein


Domain annotation for each model (and alignments):
>> ACC_central  Acetyl-CoA carboxylase, central region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  578.8   7.5  9.6e-177  1.6e-173       1     728 [.     736    1445 ..     736    1450 .. 0.92

  Alignments for each domain:
  == domain 1  score: 578.8 bits;  conditional E-value: 9.6e-177
                   EESXCCCXXXXEBXXSXXXXXX-SS.STTSCHHHHHHHHCHHHHHHHHT-S.....HTTTCCHHHHHHHHHHTSTCHHHHHHHHHHCCCTTTS-HH CS
  ACC_central    1 eLDDpskVkkaepFegqlpelgsptsvvgekphqrlaallsaleniLaGYd.....nqakiketlkeLievLrdpeLPllelqevlsalsgrlPak 91  
                   +LDD+s+Vk++ pFegq+p++ + +      p+++++++l++++n+LaGYd     +++k++et+ +L + L d++  ++e+ e ls+l++ lP +
   EFC36537.1  736 DLDDKSQVKRSLPFEGQFPPAAKVN-A-RLPPNRVVSSALETVQNLLAGYDypafiFNDKLSETMLSLRK-LGDRNVIIHEMIEKLSVLRKFLPVS 828 
                   69****************9996644.2.23589999********************************98.************************* PP

                   HHHHHHHHH............HHHHHC..T..SS--HHHHHHHHHHHCTT-TTTTTTTTHHHHSHHHHHHHCCCTTCCHHHHHHCCCCCCCHHHHH CS
  ACC_central   92 lekslrkel............ekaasnitsvlaeFPakqlrkildsflaeltkkadrevlealvqplvqlverYrnGlkghelsvvlsLLeeYlev 175 
                   l ++++++l            ++ ++++++v++e   k++++i+++f + l+  a++e +  + +p+++l+e ++nG k+h++s++++LLeeY+++
   EFC36537.1  829 LVREVNNLLqkrkieydeyccKDDNDHTQDVYNEDLVKEITSIFKNFESGLEG-AKKEEFLIAAKPVFELLELFNNGYKQHAFSTLAKLLEEYIQT 923 
                   ******99999999***99*988888889*********************996.6999************************************** PP

                   HHHHT.ST..-HHHHHHHHHHH-STCHHHHHHHHHHHHTHHHHHHHHHHHHHHCHCCCCHTCCCCCCCHHHHHCCCT--STTTHHHHHHHHHHHHH CS
  ACC_central  176 EklFqdgs..reedvvlkLReknkddlakVvdivlShsqvskKnkLilalldelkpekpssselakelrevLkkLasLesketskVaLkArevLiq 269 
                   Ek+F+++   r e v+ +LR+k++++l+k ++i lSh ++s+Knk+i +ll+ ++     + ++ ke +++L +Las+ + e s+Va+ A+++L +
   EFC36537.1  924 EKIFDTTGgkRREAVWFELRQKHSENLNKTYQIGLSHFRLSSKNKVIRSLLEIIE-----ELDMVKESTPLLDELASFVAPEFSDVAVAAKHILTS 1014
                   ****987789*********************************************.....347999****************************** PP

                   HSSHHHHHHHHHHHHHHHHHHSBSSTTSS-SS--HHHHHHHHT-SS-SHHHHCCCCCSSSHHHHHHHHHHHHHHHTTTSEEEEEEEEESS.STCEE CS
  ACC_central  270 aklPsleerknqmesilkssvdesgygeskrepslevlkeLidsettvfDvLpsfFyhsdevvrlaalevYvrraYraYelksiqhheeeespliv 365 
                   ++lPs ++ k++me  +k+ ++   +     +++l  lkeLi +++  fD+L +fF++ de +++ a+evY+r+aY +++++  +  ++  ++ +v
   EFC36537.1 1015 SRLPSKQRMKDEMEGYFKDGLEAVDN-----QQKLACLKELIVKSNYSFDILLEFFSDPDERIANLAAEVYIRKAYCTFDIDISRVTSQP-KFKTV 1104
                   ******************99988886.....999***********************************************777777766.9**** PP

                   EEEEE-T---TCGCSSS--SSSSS-B--TT-EEESSTTTS--S-SSSS--EEEEEEEESSCCGHHHHHHCHHCTS-----------....------ CS
  ACC_central  366 ewqFklpsshseeksasssstsssesesskriasvsdlsslsskseeepkrtGvmvafksledleealdevleefeeskksesseekeeeeeesss 461 
                   e++F+  + +s++ s      +s+    s    s+  lssl  +++e +  +Gv+++f+s++d++ +l++v++ fe                 +++
   EFC36537.1 1105 EFSFMNTE-KSTSGS-----LKSDGIVGS---ISMDCLSSL--SETEDNIGFGVLAIFDSVSDIDAHLPDVMKIFE-----------------NND 1172
                   *****322.222222.....223333333...244444444..334667**************************2.................345 PP

                   -----EEEEEEECETTT-S.CCCCCCCCHHHHHHCCCHHHHTTEEEEEEEE--TS---EEEEEET..TTEEECTTCTS-CCCHHHCTCCCGTTEEE CS
  ACC_central  462 seepinvlnvairsaenad.deellekleeilkelkeeLeaagvrrvTfivgrkgeyPkyfTFrerdeykEdeiiRhiEPalafqLELnrLsnfdi 556 
                   +++++nvl++++r +  +  d ell +l+++lk+++e+L+ ++++rvT++v  + ++P yfTFr+r +y+Ed+++RhiEP lafqL L++Lsn++i
   EFC36537.1 1173 DADNTNVLKILLRAHGPTPnDVELLPSLTNLLKKHSESLQYNEIKRVTVVVEVQDKLPFYFTFRQRFNYDEDPMYRHIEPTLAFQLFLKKLSNYNI 1268
                   7899*********5544447*******************************99******************************************* PP

                   EEE--SSTTEEEEEEEESS-T.......T-EEEEEEEEE-BSS--TTS-HHCHHHHHHHHHHHHHHHHHHH....C--TTBSSEEEEEEEEEEESS CS
  ACC_central  557 kpvptenrqiHlYeavakeee...kkevtdkRfFvRaiirhsdlrdkeasaeyliseaerlllealdeLEva.skkeakrtdlnHiFlnfvpevel 648 
                   +p+p+++ ++H++++++k+e    + +  +kRfFvR+++ ++d+ ++e+ +e  ise er+++ ++++LE+a ++k++ ++  nHiF+nf+pev +
   EFC36537.1 1269 TPYPCKDPSVHVFYGQKKKELglnRYDFLNKRFFVRTLVLQGDIFTEENPEELQISELERYVVASINALEIAmADKNYPTSYANHIFVNFLPEVVV 1364
                   ******************998887889999****************************************************************** PP

                   -HHHHHHHCCCHHHHHHHHHHHTTEEEEEEEEEEC-TTT-SEEEEEEEEEETTSSCEEEEEEEEEE-TT.SSEEEEESS.T CS
  ACC_central  649 dpeeveeavrsflerygkRlwrLrVlqaEirivirlsetgkaiplRlvitnesGyvlkielYkEvkdektgevvfksig.k 728 
                   + ++v e++++f + ygkRlw+LrV+++E+r++ + s+t++++++R+++ +++Gy l++++Y+E kd++tg++v+k++  +
   EFC36537.1 1365 KADMVGEIIERFQKVYGKRLWKLRVSEVEVRFTAKFSRTSQPQTFRFIALDDTGYNLTLDVYREEKDQTTGRTVYKTVVgE 1445
                   ****************************************************************************98534 PP

>> Carboxyl_trans  Carboxyl transferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  526.1   0.1  4.8e-161  7.9e-158       2     494 .]    1551    2108 ..    1550    2108 .. 0.96

  Alignments for each domain:
  == domain 1  score: 526.1 bits;  conditional E-value: 4.8e-161
                      SCTTCEEEEEEEEHTTSGGGEBEHHHHHHHHHHHHHHHHHT..EEEEEEEESBETTEEHHHHTTEEEEESSTTSGGGCEE...ECHHHHHHHH CS
  Carboxyl_trans    2 ehprGkltareridllldpgsFgeledlffhrvtelgrkkklprdgvvtgsGaviGravevvaqdktvlggslgpakgek...llkaqeeaik 91  
                      e + G++++++++d+++++gsFg +ed++f+ ++e++rk k+pr +++++sGa+iG a+ev + +k  ++ + + +kg+k   l++ ++e+++
      EFC36537.1 1551 EAKDGRDMILIANDITYQSGSFGVIEDEVFQLASEMARKLKIPRFYIAANSGARIGLADEVRELFKIEWNEPNDSTKGFKylyLTPNDYEKLQ 1643
                      7789****************************************************************************9999999999999 PP

                      H............TEEEEEEEEE-ES.SSGHHSSHHHHHHHHHHHHHHHHHHHCS-EEEEESSEEETHHHHHHHHTSEEEEETTEEEEESSTH CS
  Carboxyl_trans   92 a............gepligindsgGa.egriqegveslrgsGkifgenskasgeIpqislvtgrcaGggaYlpalgdrvimveetskifltGp 171 
                      +            ge++++i d++G+ +g    gve+lrgsG+i+ge+s+a++e++++ ++  r++G+gaY+ +lg+r+i+ ++ ++i+ltG+
      EFC36537.1 1644 KtnsvnaveievnGEKRWKIIDIIGKeNG---IGVENLRGSGMIAGETSRAYEEVFTMNYIAARSVGIGAYVNRLGQRIIQNRK-APILLTGA 1732
                      9*************************555...****************************************************.******** PP

                      HHHHHHHSSCC-SSCHHHHSHHHHTTTTSSSEEESSHHHHHHHHHHHHTTS-SSTTSGGSS----ECSSGSSSH..HCS-CTTTS---HHHHH CS
  Carboxyl_trans  172 dvikkvlgreevtseelgGatqhmtksGvahltaeddeealelirkllsylPkkasnnresaPivetadepdrdlieivPdnakkpyDvrevi 264 
                       +++kvl re++ts+ ++G+ q+m  +Gv+hl+a+dd  a++   k+lsy+Pk++ +   + Pi++t d+p+r+ i++ P  +   yD re++
      EFC36537.1 1733 GALNKVLSREVYTSNLQLGGIQIMNPNGVTHLIAKDDYLAIKDALKWLSYVPKSVGS---ALPILKTLDDPERQ-IQYLPV-EGSHYDFREML 1820
                      ****************************************************88888...9************6.******.699*******9 PP

                      HCEEC...............TTC-EEESTTSSTTEEEEEEEETTEEEEEEEE--S....................EEETTEE-HHHHHHHHHH CS
  Carboxyl_trans  265 arlvd...............egeFlEikegyAktvVvGfArlgGipvGvvAnetr....................veaGqvlfidsavKaarf 322 
                       +++                +++F+E++ g+Ak+++v++ArlgGip+Gv+A+ t+                    +++Gqv+++dsa+K+a++
      EFC36537.1 1821 VGKTVegengestwlsgffdKNSFFETLTGWAKNIIVARARLGGIPMGVIAVDTKtyeqiipadpadsnsrervvQKSGQVWYPDSAFKTAQA 1913
                      998878*************************************************************************************** PP

                      HHHHHH.TT--EEEEE-BSEE--SHHHHHTTHHHHHHHHHHHHHT--S-EEEEE-T..EEEHHHHHTTTGGGSTTTTE..EETTT-EEESS-H CS
  Carboxyl_trans  323 irlcda.enlPlviladvrGflvGqrqeyggilkhGaklvdalaeakvPkitvilr..kayGGayvvmdskingadlv..aawptariaVlgp 410 
                      i+++++ e+lPl+i+a++rGf++Gqr+++++ilk+G+++vdal ++k+P++++i++  +++GGa+vv+d+ in++ ++  +a+ ++++++l++
      EFC36537.1 1914 INDFNKgEQLPLMIFANWRGFSGGQRDMFDEILKFGSYIVDALTNYKQPVFVYIPPngELRGGAWVVVDPMINND-VMemFADDKSKGGILEA 2005
                      ***********************************************************************9888.7779999********** PP

                      HHHHHHHSHHHHHHHHHHH..................HHHHHH....HHHHHHHHHHHHHHHHHHHHHHHHHTTSSHHHHHHTTSSSEEEHGG CS
  Carboxyl_trans  411 egaveilfrkekaaaemer..................kdlaae....rkkklkeyeeellnpyvaaargfaDavidpsetraklvialelewk 481 
                      +g+vei++rk++  a+ +r                       +    +k k+ ++ e+l+++y+++a  faD++++p++++ak+vi + ++wk
      EFC36537.1 2006 SGIVEIKYRKQEIVATIQRldaeyinlakelgrsdisL----KekdeIKVKMGKRVEKLIPIYTQVAECFADLHDTPGRMKAKGVITEIISWK 2094
                      *******************9999976666666655442....04455********************************************** PP

                      GHH.HHHHHHHHHH CS
  Carboxyl_trans  482 kar.klparkrrni 494 
                      +ar ++++r++r i
      EFC36537.1 2095 TARtYFYWRLKRKI 2108
                      **********9976 PP

>> CPSase_L_D2  Carbamoyl-phosphate synthase L chain, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.4   2.4e+03     125     172 ..      70     116 ..      64     117 .. 0.84
   2 !  167.8   0.0   1.4e-52   2.3e-49      22     210 ..     201     385 ..     185     386 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.4
                  EEEES-SS--HHHHHHHHHHHHHHHHHHT-EEEEEEEEEEETTTTEEE CS
  CPSase_L_D2 125 ievAPsqtLtdeerqalreaavkvvrevgvvgagtveflldpkskeyy 172
                  +   P     ++e+ +l  + vkv  e ++ +  +v+ ++d   ++++
   EFC36537.1  70 VMATPEDIQANAEYVRLADELVKVPGESNYNNYSNVKLIVDI-AEQFC 116
                  4555777778899***************************96.67765 PP

  == domain 2  score: 167.8 bits;  conditional E-value: 1.4e-52
                  SSBSSHHHHHHHHHHH-SSEEEEETTCCTTTTEEEESSHHHHHHHHHHHHHHHHHHHSTS-EEEEE--SSSEEEEEEEEEETTS-EEEEEEEEECCEC CS
  CPSase_L_D2  22 apvetleealaiakeigyPviikaafglGGkGmrvarneeelaelvkkalaeakaafgnkqvlvekslkgpkeiEvevlrDakgnvitvcerenslql 119
                  + ++++ eal++a++igyP++ika+ g+GGkG r + n+ el+  +++  +e +     + +++ k  ++ +++Ev+v++D++gn++ + +r++s+q+
   EFC36537.1 201 CCITSESEALKCANKIGYPIMIKASEGGGGKGIRKVANDIELKLGFSQVKNEVP----GSPIFLMKLSSESRHLEVQVVADKHGNALALYSRDCSVQR 294
                  4578999******************************************99996....7789999********************************* PP

                  TCCCCEEEES-SS--HHHHHHHHHHHHHHHHHHT-EEEEEEEEEEETTTTEEEEEEEESS--CCHHHHHHHHS--HHHHHHHHHTT--GCG CS
  CPSase_L_D2 120 rtqkvievAPsqtLtdeerqalreaavkvvrevgvvgagtveflldpkskeyyviEvNtRlsvesalaekaTGldlvkeaakialgekLee 210
                  r+qk+ie+ P  +  ++  +++++aav+++r+v+++gagtve+l++p +++ y++E+N+Rl+ve++++e +T  ++  ++++ia+g++L+ 
   EFC36537.1 295 RHQKIIEEGPVTVAPKHVIDKMEAAAVTLARSVNYSGAGTVEYLYEPATEHVYFLELNPRLQVEHPVTEWITLTNIPSIQLQIAMGISLNR 385
                  ****************************************************************************************985 PP

>> Biotin_carb_N  Biotin carboxylase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.3   0.0   1.1e-31   1.7e-28       2     107 ..      33     151 ..      32     154 .. 0.93

  Alignments for each domain:
  == domain 1  score: 99.3 bits;  conditional E-value: 1.1e-31
                    --EEEE---HHHHHHHHHHHHHT.........T-EEEEEEEGG..GTTSHHHHHSSEEEEEESSTTCCGGG-HHHHHHHHHHTT-SEEE--SSTTT CS
  Biotin_carb_N   2 ikkvlianrGeiAvriiravrel.........gietvavysee..danslhvreadeavelgpasasesYlniekivkaakesgadavhpGyGfls 86 
                    ikk+lian+G +Av+ ir++r++         +i++v+++++e  +an+++vr+ade v+++++s+ ++Y n++ iv++a++  +dav+pG+G++s
     EFC36537.1  33 IKKILIANNGIAAVKGIRSMRKWcnevfgksdEIKFVVMATPEdiQANAEYVRLADELVKVPGESNYNNYSNVKLIVDIAEQFCCDAVWPGWGHAS 128
                    89*****************************************4446788********************************************** PP

                    T-HHHHHHHH..HTT-EESSS-H CS
  Biotin_carb_N  87 Enaefaeave..eagivfiGPsa 107
                    En+e++ +++  +++i+fiGP++
     EFC36537.1 129 ENPELPFSLSqtKRQIAFIGPDS 151
                    ****99888733699******86 PP

>> Biotin_carb_C  Biotin carboxylase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.3   0.0   5.2e-25   8.5e-22       2     107 ..     425     531 ..     424     532 .. 0.99

  Alignments for each domain:
  == domain 1  score: 77.3 bits;  conditional E-value: 5.2e-25
                    EEEESEETTTTTEE--CE-SEEE---STTEEEEE---TT-EE-TTS-SEEEEEEEEESSHHHHHHHHHHHHHT-EEES.S-BSHHHHHHHHH-HHH CS
  Biotin_carb_C   2 aRinaEdpeknflpssGkvtelelpegpgvRvdsgveegsevspyyDsllaKlivhgetreealarlrraLaelrieG.vktnieflrailedeef 96 
                    +R++aE+pe++f+p+ G v el++ ++p+v+ + ++++   ++++ Ds +++++++getreea +++ ++L+el i+G ++t++e+l+++l+ +++
     EFC36537.1 425 CRVTAENPESGFQPTCGSVVELNFRTNPNVWGYFSIRSQGAIHAFSDSQFGHIFTKGETREEARKTMLSTLSELAIRGeIRTTAEYLQSLLKFDDY 520
                    9*********************************************************************************************** PP

                    HHT---TTTCC CS
  Biotin_carb_C  97 akgeldtkfle 107
                    ++++++t++l+
     EFC36537.1 521 VNNNYTTSWLD 531
                    **********8 PP

>> Biotin_lipoyl  Biotin-requiring enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.8   0.0   8.6e-14   1.4e-10       7      73 .]     675     735 ..     669     735 .. 0.91

  Alignments for each domain:
  == domain 1  score: 40.8 bits;  conditional E-value: 8.6e-14
                    SSEEEEEE.ECSESSSTTCEE-TTSEEEEEECTTEEEEEEBSSSEEEEEESSTTTEEE-TTCEEEEE CS
  Biotin_lipoyl   7 miGesveegvvevlvkvGdkVkagqvlaeveamKmemeieapkaGvvkeilvkeGdtvevgdllaki 73 
                      G++++     +lv++G +Vk + ++ae+e+mKm +++ ap  G+v   lv+ G+ v++gd++a+i
     EFC36537.1 675 LSGKFMK-----YLVENGAHVKPNTPVAELEVMKMIVTVYAPLPGRVNHCLVD-GTGVNQGDIIAII 735
                    4566666.....*****************************************.**********987 PP

>> ATP-grasp_3  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.0   8.9e-10   1.5e-06      13     159 ..     188     356 ..     181     358 .. 0.83
   2 ?   -1.3   0.0       1.2   1.9e+03      50     131 ..     901     980 ..     897     984 .. 0.81

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 8.9e-10
                  TT.S---..............-EESS--....SSSEEEEESS-------B--SS--TTE................EEEE---SEEEEEEEEE.SSSE. CS
  ATP-grasp_3  13 eagvkvP..........tkleaeeleee....ekklvvKprdGaggesvrvveekeeaeaaieeve.........lvqefieGkplSvsllsdgekv. 86 
                  ++g+++P          ++ ea +         +++ +K ++G+gg+++r+v ++ e++  + +v+         l++   e+++l v++++d++ + 
   EFC36537.1 188 KSGLPIPediylkccitSESEALK---CankiGYPIMIKASEGGGGKGIRKVANDIELKLGFSQVKnevpgspifLMKLSSESRHLEVQVVADKHGNa 282
                  566677766666544332222222...1333599*************************999999999*****99999999***********987651 PP

                  EEEEEEEEEEET....TEEEEEEES----HHHHHHHHHHHHHTTSTT--EEEEEEEEESS...SEEEEEEESS-- CS
  ATP-grasp_3  87 lvlavnrqliekaekefvyaGnvtpietelkeevvelaeevvekleglaGyvGvDlvlkd..eepyviEvNPRlt 159
                  l l   +  +++++++++  G vt ++++  ++++++a  + +++ +  G   v+ +++   e  y++E NPRl+
   EFC36537.1 283 LALYSRDCSVQRRHQKIIEEGPVTVAPKHVIDKMEAAAVTLARSV-NYSGAGTVEYLYEPatEHVYFLELNPRLQ 356
                  5566666678888888*****************************.***********9877799*********97 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.2
                  -SS--TTE.......EEEE---SEEEEEEEEE.SSSEEEEEEEEEEEET....TEEEEEEES----HHHHHHHHHHHHHTTS CS
  ATP-grasp_3  50 veekeeaeaaieevelvqefieGkplSvsllsdgekvlvlavnrqliekaekefvyaGnvtpietelkeevvelaeevvekl 131
                  ++++ +++a+    +l+ e+i+ +++  ++ ++  +++ + + +++ e+  ++  y+ +++ ++ + k++v++   e++e+l
   EFC36537.1 901 FNNGYKQHAFSTLAKLLEEYIQTEKIFDTTGGKRREAVWFELRQKHSEN--LNKTYQIGLSHFRLSSKNKVIRSLLEIIEEL 980
                  5666667777777779999999999888888888888888888888876..77899999**************999999999 PP

>> ATP-grasp  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   4.2e-07   0.00068      12     159 ..     201     354 ..     186     357 .. 0.80
   2 ?   -2.6   0.0       2.2   3.6e+03      87     146 ..    1520    1582 ..    1516    1587 .. 0.70

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 4.2e-07
                 EEECCHHHHHHHHHHH-SCEEEEESSS-CTTTTEEEECTCCGHHCHHHHC....GTTCEEEEE----SEEEEEEEEEETTC-.EEE--EEEEEEETTEE CS
   ATP-grasp  12 laveskeeleeaaeelglpvvvKarrlgydGkGqsvvrseedleqaleal....keekvivEefvpfekElsvlvvrsaeGe.tafypvvetvqedgil 105
                 + ++s++e+ + a+++g+p+++K +  g  GkG   v ++ +l+  ++++     + ++ + +  + ++ l v vv +++G+  a y     vq++   
  EFC36537.1 201 CCITSESEALKCANKIGYPIMIK-ASEGGGGKGIRKVANDIELKLGFSQVknevPGSPIFLMKLSSESRHLEVQVVADKHGNaLALYSRDCSVQRRHQK 298
                 4578899999*************.666779*****999999998777766555577899999999999999999999****955677777777776666 PP

                 EEEEECEE-.SCHHHHHHHHHHHHHHHHHTSSEEEEEEEEEE.TTCTEEEEEEESS CS
   ATP-grasp 106 rlsvapaev.sekaqkkaeeiakkiveeLggvGvfavElFvl.edgellvnElapR 159
                  +   p +v +++   k e+ a ++++++++ G  +vE  +  +++++++ El pR
  EFC36537.1 299 IIEEGPVTVaPKHVIDKMEAAAVTLARSVNYSGAGTVEYLYEpATEHVYFLELNPR 354
                 66666666515568899999999***************877725555********9 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.2
                  TC-EEE--EEEEEEETTEEEEEEECEE-...SCHHHHHHHHHHHHHHHHHTSSEEEEEEEEEE CS
   ATP-grasp   87 eGetafypvvetvqedgilrlsvapaev...sekaqkkaeeiakkiveeLggvGvfavElFvl 146 
                   G++ + ++v++   ++++ ++v   ++   ++k+ +    ia++i+ + g  Gv+  E+F+l
  EFC36537.1 1520 TGKFLIENPVKNAIGKNTCGMVVWKVTLftpEAKDGRDMILIANDITYQSGSFGVIEDEVFQL 1582
                  677777888888888888876665554411133455667778899999999999999999987 PP

>> Biotin_lipoyl_2  Biotin-lipoyl like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.22   3.6e+02       4      26 ..     670     692 ..     667     701 .. 0.88
   2 !   15.4   0.1   7.3e-06     0.012       3      36 ..     706     738 ..     695     747 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.22
  Biotin_lipoyl_2   4 sIaapvsGrVaqlnVkdGqrVka 26 
                      ++ + +sG+  + +V+ G +Vk 
       EFC36537.1 670 QLRSTLSGKFMKYLVENGAHVKP 692
                      677889***************95 PP

  == domain 2  score: 15.4 bits;  conditional E-value: 7.3e-06
  Biotin_lipoyl_2   3 vsIaapvsGrVaqlnVkdGqrVkaGdvLaelDsr 36 
                      v++ ap++GrV   +V dG  V++Gd++a++D +
       EFC36537.1 706 VTVYAPLPGRVNHCLV-DGTGVNQGDIIAIIDLD 738
                      8999***********9.9**************65 PP

>> Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0     2e-06    0.0032      21     173 ..     205     352 ..     186     354 .. 0.68

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 2e-06
                      CH-H-HHHHHHHHHC-SSEEEEESSSSTTTTEEEESSGGGHHHHHHHHHTT..-SCEEEEE--.ESEEEEEEEEETSSCEEEEEEEEE-SSSSS CS
  Dala_Dala_lig_C  21 keekkellekveeelgypvfVKpareGSSvGvskveseeelkeaieeafky..dekvlvEeai.egreievavlgneklevsevgeivvkkgfy 111
                      +e++     k+ +++gyp+++K+++ G   G+ kv +  elk  +++  +    + ++  +   e r +ev v+ + + +++ +  +    ++ 
       EFC36537.1 205 SESE---ALKCANKIGYPIMIKASEGGGGKGIRKVANDIELKLGFSQVKNEvpGSPIFLMKLSsESRHLEVQVVADKHGNALALYSRDC--SVQ 293
                      4444...67899*****************************987776655422345666665559999999999977777776655444..445 PP

                      -HHHHHC.TT-EEESS----HHHHHHHHHHHHHHHHHTT--SEEEEEEEE.ETTTEEEEEEEE CS
  Dala_Dala_lig_C 112 dyeakysddkaqlevpaklekeveekiqelalkaykaldlrGlaRvDffl.teegeivlnEvN 173
                      + ++k +++    + p    k+v +k++++a+   + ++ +G + v +++  +++++++ E+N
       EFC36537.1 294 RRHQKIIEEGPVTVAP----KHVIDKMEAAAVTLARSVNYSGAGTVEYLYePATEHVYFLELN 352
                      6667776444333333....3445555666666667778888888888886677788888887 PP

>> GCV_H  Glycine cleavage H-protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0    0.0004      0.65      38      72 ..     683     717 ..     671     728 .. 0.89
   2 ?   -0.7   0.0      0.78   1.3e+03      29      67 ..    1749    1787 ..    1745    1799 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0004
                 ---TT-EE-TT-EEEEEEESS-EEEEE-SSSEEEE CS
       GCV_H  38 lpevgtkvkkgeslaavEsvKaasevyapvsGevv 72 
                 l e+g++vk + ++a +E  K++ +vyap+ G v 
  EFC36537.1 683 LVENGAHVKPNTPVAELEVMKMIVTVYAPLPGRVN 717
                 6799****************************984 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.78
                  HH-SEEEEE---TT-EE-TT-EEEEEEESS-EEEEE-SS CS
       GCV_H   29 elgdvvfvelpevgtkvkkgeslaavEsvKaasevyapv 67  
                  +lg +  ++   v + ++k++ la+ ++ K+ s v++ v
  EFC36537.1 1749 QLGGIQIMNPNGVTHLIAKDDYLAIKDALKWLSYVPKSV 1787
                  6888888899999999*****************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 1.18u 0.36s 00:00:01.54 Elapsed: 00:00:00.54
# Mc/sec: 12293.39
//
Query:       EFC36538.1  [L=550]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.045   13.8   0.4       0.48   10.5   0.0    2.8  2  Bcr-Abl_Oligo   Bcr-Abl oncoprotein oligomerisation domain
      0.067   13.1   2.0       0.15   12.0   0.2    2.6  2  TFIIE_alpha     TFIIE alpha subunit
       0.16   11.8   6.1        1.7    8.5   0.0    3.4  4  Apolipoprotein  Apolipoprotein A1/A4/E domain
       0.21   11.6   1.5        1.7    8.7   0.0    2.9  3  PilJ            Type IV pili methyl-accepting chemotaxis tran
       0.57   10.3   5.2       0.22   11.6   1.3    2.4  2  Spore_III_AB    Stage III sporulation protein AB (spore_III_A
        1.9    8.3  11.2        0.7    9.8   4.9    3.1  2  CheZ            Chemotaxis phosphatase, CheZ
        7.7    7.1  14.3        4.7    7.7   1.1    4.2  4  NPV_P10         Nucleopolyhedrovirus P10 protein


Domain annotation for each model (and alignments):
>> Bcr-Abl_Oligo  Bcr-Abl oncoprotein oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00019      0.48      15      54 ..     113     152 ..     107     159 .. 0.92
   2 ?   -1.1   0.1      0.77     2e+03      38      63 ..     503     528 ..     499     536 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00019
  Bcr-Abl_Oligo  15 eeevPkmeLdsvedieqeLerCkaslrrLekelneekfkv 54 
                    ++++P++e+++v ++e++L +   +l rL+ +ln +k +v
     EFC36538.1 113 NDDIPYLEVSTVLELENDLTHVYRNLYRLRTQLNANKSQV 152
                    5789******************************998765 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.77
  Bcr-Abl_Oligo  38 aslrrLekelneekfkviyLqtllak 63 
                    a++++L ++++ ++ kv  L   l k
     EFC36538.1 503 ANVKELAQRVEDQRRKVDDLSENLMK 528
                    67888888888888777666555544 PP

>> TFIIE_alpha  TFIIE alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.2   5.7e-05      0.15      24      78 ..     148     205 ..     131     232 .. 0.82
   2 ?   -1.7   0.1         1   2.7e+03      48      77 ..     333     362 ..     317     384 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 5.7e-05
                  CTTSEBHHHHHHHHTS-HHHHHHHHHHHHHCTSEEEEEEEE...TTTEEEEEEEEEEC CS
  TFIIE_alpha  24 ekgevteedlakelkidlnelrklLnrLyearlvkykrrrd...eekswykyywriny 78 
                   k++v++ +   ++ i +n++ k+Ln++ e  lv  k+ +    e  s y  y+ +  
   EFC36538.1 148 NKSQVKDTNFLLLTDITINNITKVLNEMVELSLVLPKKVKGsseEVSSSYGQYYNPMN 205
                  689*******************************888888744255556666776555 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1
                  HHHHHHCTSEEEEEEEETTTEEEEEEEEEE CS
  TFIIE_alpha  48 LnrLyearlvkykrrrdeekswykyywrin 77 
                  ++ L+e++    k++  ++ + ++yy r++
   EFC36538.1 333 IYSLQEDKSEPTKKKNRPNVTAKSYYERFK 362
                  788888888888888888888888886655 PP

>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.53   1.4e+03      16     182 ..     127     153 ..     121     156 .. 0.47
   2 ?    8.5   0.0   0.00067       1.7     103     180 ..     250     332 ..     187     341 .. 0.85
   3 ?   -3.0   0.0       2.1   5.5e+03     104     117 ..     357     370 ..     347     374 .. 0.54
   4 ?    4.1   0.7     0.014        37      61      92 ..     505     536 ..     495     543 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.53
                     HHHCHHCHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHCCHHCHCCHCHHHHHH CS
  Apolipoprotein  16 leeqlaplaq...elrdrlskeleelrarlraeleevrarlepyrdevqeqlgqnleelrqrlapyteelrerlaadaeelqeqlavyaeelrer 107
                     le+ l+++++   +                                                                                 
      EFC36538.1 127 LENDLTHVYRnlyR--------------------------------------------------------------------------------- 140
                     44444444444444................................................................................. PP

                     HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH-----..-----SSSHHHHHHHTS-TTSHHHHHS--XXXXXXX CS
  Apolipoprotein 108 lerhvealkarlapyveelrqklaerleelkeslaphaeeveerlssrveelrekleeqaeelrerleanleelk 182
                                                                                   lr +l+an++++k
      EFC36538.1 141 --------------------------------------------------------------LRTQLNANKSQVK 153
                     ..............................................................4444444444444 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00067
                     HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH-----..-----SSSHHHHHHHTS-T.....TSHHHHHS--XXXXX CS
  Apolipoprotein 103 elrerlerhvealkarlapyveelrqklaerleelkeslaphaeeveerlssrveelreklee.....qaeelrerleanlee 180
                     +++++    ++++ +    y+ e+ ++++++  ++  +++p++ ++++  ++ +e++ +++e+     + e+lr+ l +++++
      EFC36538.1 250 QMKQEELNIMSKTSTFYNSYFSEMLKEIEQKYNDFTGQVTPSSVSSKSVNQEIIEDIVQSFEDfdresNEENLRHFLMTFKDN 332
                     467777777899999999********************************************987777777787777777665 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 2.1
                     HHHHHHHHHHHHHH CS
  Apolipoprotein 104 lrerlerhvealka 117
                     + er ++hve++++
      EFC36538.1 357 YYERFKAHVEEIQT 370
                     33444444444443 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.014
                     HHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHC CS
  Apolipoprotein  61 qeqlgqnleelrqrlapyteelrerlaadaee 92 
                      ++l+q++e+ r++++ ++e+l+++ + d+++
      EFC36538.1 505 VKELAQRVEDQRRKVDDLSENLMKKSLSDMQK 536
                     57899999999999999999999988888875 PP

>> PilJ  Type IV pili methyl-accepting chemotaxis transducer N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.66   1.7e+03      41      60 ..     221     240 ..     205     258 .. 0.77
   2 ?    8.7   0.0   0.00067       1.7      32      94 ..     308     371 ..     297     382 .. 0.82
   3 ?   -0.7   0.1      0.56   1.4e+03      39      74 ..     500     535 ..     488     546 .. 0.57

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.66
        PilJ  41 aearaqlretiaqfdrtlaa 60 
                 ++ +++++++i+qf + ++a
  EFC36538.1 221 SKTSKEVEDAIKQFVKAFHA 240
                 66788888888888887776 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00067
        PilJ  32 laaagaydaaearaqlretiaqfdrtlaalrlgdpapgllvpae..avraqleaveqlWqelkkp 94 
                 + +    d++++ ++lr+ + +f +++++l++  ++p+ ++ +   + ++ +e+  ++ +e +  
  EFC36538.1 308 QSFEDF-DRESNEENLRHFLMTFKDNIYSLQEDKSEPTKKKNRPnvTAKSYYERFKAHVEEIQTE 371
                 444444.8999*************************98888777898899999999998887765 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.56
        PilJ  39 daaearaqlretiaqfdrtlaalrlgdpapgllvpa 74 
                  ++++ ++l++++++ +r ++ l++   + +l +++
  EFC36538.1 500 SQNANVKELAQRVEDQRRKVDDLSENLMKKSLSDMQ 535
                 455566666666666666666666554444444444 PP

>> Spore_III_AB  Stage III sporulation protein AB (spore_III_AB)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   1.3   8.5e-05      0.22      54     150 ..     258     343 ..     218     346 .. 0.71
   2 ?   -2.8   0.1       2.3   5.8e+03     120     144 ..     496     520 ..     490     540 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.5e-05
                   HHHHHHHCS-TTHHHHHHHHHHHHH.STSS-HHHHHHHHHHHHGGGS---HHHHHHHHHHHHHHT--SHHHHHHHHHHHHHHHHHHHHHHHHHHHHT CS
  Spore_III_AB  54 aleklaeksesplseffeevaerleekegesfeeaweeavekllkklaLkkedkeilkelgeslgysdregqlkalelaleeleeeieeareeakkk 150
                   +++    k++  ++++f+e+ +++e+k ++  +++  ++v++       k   +ei+ ++ +s+   dre+++++l+ +l  ++++i  ++e++ + 
    EFC36538.1 258 IMS----KTSTFYNSYFSEMLKEIEQKYNDFTGQVTPSSVSS-------KSVNQEIIEDIVQSFEDFDRESNEENLRHFLMTFKDNIYSLQEDKSEP 343
                   333....44445777777777777765555555666666666.......466679************************************998775 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.3
                   -SHHHHHHHHHHHHHHHHHHHHHHH CS
  Spore_III_AB 120 sdregqlkalelaleeleeeieear 144
                   s++ +q ++++ + +++e++ ++  
    EFC36538.1 496 SSKVSQNANVKELAQRVEDQRRKVD 520
                   5555566666666666666555543 PP

>> CheZ  Chemotaxis phosphatase, CheZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   4.9   0.00028       0.7      72     178 ..     222     352 ..     126     364 .. 0.69
   2 ?   -0.4   0.4      0.35     9e+02      91     114 ..     502     525 ..     472     545 .. 0.53

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00028
                 XXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXX..XX. CS
        CheZ  72 eeakeleeewerllerelekee.frelvkeveaflkeveektealkkqLleil..maQdfqDLtGQvikkvie...lvkeveskLvqllleasekeek. 163
                 +++ke+e+++++++++  ++++ f+  ++  ++ l+ ++++++  ++ ++e+l  ++Q ++D tGQv    ++   + +e+ +++vq   ++ +++++ 
  EFC36538.1 222 KTSKEVEDAIKQFVKAFHAQKTlFELDLQMKQEELNIMSKTSTFYNSYFSEMLkeIEQKYNDFTGQVTPSSVSsksVNQEIIEDIVQSFEDFDRESNEe 320
                 456667777777776665544425555556666788888888889999999996679**********97655411144445555555555544433334 PP

                 ......................XXXXXXXXXX CS
        CheZ 164 .................ekkeekeeeleGPvi 178
                                  e+k+e +++ + P +
  EFC36538.1 321 nlrhflmtfkdniyslqEDKSEPTKKKNRPNV 352
                 56666666666666555445555555555555 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.35
                 XXXXXXXXXXXXXXXXXXXXXXXX CS
        CheZ  91 keefrelvkeveaflkeveektea 114
                 + +++el+++ve+  ++v++ +e+
  EFC36538.1 502 NANVKELAQRVEDQRRKVDDLSEN 525
                 333444444444444444433333 PP

>> NPV_P10  Nucleopolyhedrovirus P10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.76     2e+03      22      56 ..      21      34 ..      10      51 .. 0.45
   2 ?    7.7   1.1    0.0018       4.7      20      67 ..     124     174 ..     113     184 .. 0.81
   3 ?   -1.9   0.0       1.9   4.7e+03      32      72 ..     347     389 ..     329     392 .. 0.66
   4 ?    5.5   0.9     0.009        23      11      36 ..     503     528 ..     477     548 .. 0.62

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.76
     NPV_P10 22 alqqqvddvqenlpdvtelnekLdaqsaqLaelet 56
                 l+ qv                     + L++  +
  EFC36538.1 21 QLERQV---------------------QLLTKCTN 34
                333333.....................33333333 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0018
     NPV_P10  20 VdalqqqvddvqenlpdvtelnekLdaqsaqLaelet......kvenIqdiLnp 67 
                 V  l++ +++v  nl     l ++L+a   q+++ +       +++nI+++Ln+
  EFC36538.1 124 VLELENDLTHVYRNLYR---LRTQLNANKSQVKDTNFllltdiTINNITKVLNE 174
                 45677777777777776...99***********9998999999**********3 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.9
     NPV_P10  32 enlpdvtelnekLdaqsaqLaelet.....kvenIqdiLnpdevPd 72 
                 +n p+vt  ++  ++  a ++e++t     k e I+++ n    P+
  EFC36538.1 347 KNRPNVT-AKSYYERFKAHVEEIQTeflirKNEFIEKMYN--LNPE 389
                 5666666.55666777778888887666665566666655..4455 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.009
     NPV_P10  11 adikavddkVdalqqqvddvqenlpd 36 
                 a++k++ ++V+    +vdd++enl +
  EFC36538.1 503 ANVKELAQRVEDQRRKVDDLSENLMK 528
                 34555555555555555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (550 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1857  (0.103575); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.50
# Mc/sec: 3325.39
//
Query:       EFC36539.1  [L=1010]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.9e-40  138.4   2.5      5e-40  137.6   0.0    2.5  3  Abhydrolase_2  Phospholipase/Carboxylesterase
    8.5e-06   25.6   0.0    2.4e-05   24.1   0.0    1.8  1  FSH1           Serine hydrolase (FSH1)
      7e-05   22.7   0.1    0.00028   20.8   0.0    2.1  2  Lipase_3       Lipase (class 3)
    0.00052   19.4   0.8       0.32   10.2   0.0    2.9  3  Hydrolase_4    Serine aminopeptidase, S33
     0.0012   18.4   0.1       0.79    9.2   0.0    2.4  2  Peptidase_S9   Prolyl oligopeptidase family
  ------ inclusion threshold ------
      0.012   15.1   0.0      0.024   14.2   0.0    1.4  1  DLH            Dienelactone hydrolase family


Domain annotation for each model (and alignments):
>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.6   0.0   1.7e-43     5e-40      14     215 ..      36     242 ..      28     244 .. 0.90
   2 ?   -2.8   0.2       1.5   4.4e+03     140     173 ..     350     382 ..     343     405 .. 0.61
   3 ?   -0.9   0.0       0.4   1.2e+03      74     105 ..     434     466 ..     430     470 .. 0.84

  Alignments for each domain:
  == domain 1  score: 137.6 bits;  conditional E-value: 1.7e-43
                    -EEEEEE--TT--SHHHHHHHH.TT--TTEEEEEE---EEE-GGGTT-EEE-SS-B--SSTTS...-B-HHHHHHHHHHHHHHHHHHHHTT--GGG CS
  Abhydrolase_2  14 qavviflHGlGdsghawaeaakteaalpnikfifphgpelpvtlnggmrmpaWfdlvglspek...kedeagikksaekleelidaelkkgipssr 106
                      +vi lHGlGd+ ++++++++ ++  +n+  i p++p++p t+nggm+m  W+d+++l+ ++   +ed +g ++s + + eli+ +lk+  +s+r
     EFC36539.1  36 DSLVIWLHGLGDNYEGFSQMLQ-VILPENTMAILPNSPQRPITINGGMVMNGWYDIYSLERQElkvHEDLEGYEASKKLIDELIESQLKQ-FDSKR 129
                    579*******************.9999********************************9998866677789999999999999999987.8**** PP

                    EEEEEETHHHHHHHHHHHT-SS--SEEEEES---TTGGGTTTTS-GGG...GG-EEEEEEETT-SSS-HH.HHHHHHHHHHTTS-GEEEEEETT-- CS
  Abhydrolase_2 107 iiigGFSqGaalalylaltlpkklggivafsgalplsqklessatavt...kklpilqiHgeeDpvvpla.lgkaakevlkkllkkvelksyegla 198
                    ii+gGFSqGaa++l ++l+++++lg i++ sg ++l++k+ +    +    k++p    Hg+eD vv ++ +++++   l+k     + k+y+  +
     EFC36539.1 130 IILGGFSQGAAMSLLTGLQSKHPLGAIISASGYMLLRSKFTNPSEFISqenKETPLYIFHGDEDDVVHYQsFASESFDWLEKGKSITSRKIYRYHS 225
                    ****************************************86443322344*****************9637788888888888899999****** PP

                    SS--HHHHHHHHHHHHH CS
  Abhydrolase_2 199 Hsideeemqdikeflkk 215
                    H+ ++eem+d+k+  +k
     EFC36539.1 226 HEVSNEEMKDLKNLFEK 242
                    ***********997766 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.5
                    -TTGGGTTTTS-GGGGG-EEEEEEETT-SSS-HH CS
  Abhydrolase_2 140 lplsqklessatavtkklpilqiHgeeDpvvpla 173
                    l++s++++++ ta++  +p l  H  ++p  ++ 
     EFC36539.1 350 LSSSPQTPQHLTASNNTTP-LNHHSCQSPSSEST 382
                    5667778888888884444.44455555544444 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.4
                    TTS.-B-HHHHHHHHHHHHHHHHHHHHTT--GG CS
  Abhydrolase_2  74 pek.kedeagikksaekleelidaelkkgipss 105
                    +++  ede+ i+  +  +  +id ++k +i  +
     EFC36539.1 434 EDEsTEDEDNIEYCVGRYIHFIDDNFKSSILGN 466
                    444489*********************999766 PP

>> FSH1  Serine hydrolase (FSH1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0     8e-09   2.4e-05      79     177 ..      97     198 ..      39     218 .. 0.79

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 8e-09
        FSH1  79 e...kneyegleesldavkdyikengp.fdG....iiGFSqGaalaallaslleellkeashpslkfailvsGfkleepkyee..yy.eedkiqtptLh 166
                 e   +++ eg+e s + + + i+++   fd     + GFSqGaa++ l + l++       + +l  +i +sG++l ++k+ +   + ++++ +tp   
  EFC36539.1  97 ElkvHEDLEGYEASKKLIDELIESQLKqFDSkriiLGGFSQGAAMSLL-TGLQS-------KHPLGAIISASGYMLLRSKFTNpsEFiSQENKETPLYI 187
                 14557788888999999999998876666544432459******9743.33333.......345899***********997774544688888****** PP

        FSH1 167 vlGelDtvvde 177
                 ++G++D vv  
  EFC36539.1 188 FHGDEDDVVHY 198
                 ********985 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   9.5e-08   0.00028      30      85 ..      74     148 ..      42     152 .. 0.81
   2 ?   -3.3   0.1       2.6   7.6e+03      18      61 ..     261     301 ..     250     307 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 9.5e-08
                 G....TT-EEEHHHHHHHH...............S-HHHHHHHHHHHHHHHTT-EEEEEEEETHHHHHHHHHHHH CS
    Lipase_3  30 k....eggkvhsgfleaye...............eslreqvlkelkrllekypeysivvtGHSLGgalAlLaald 85 
                 +    +gg v++g++++y                e  ++ + + +++ l+++ + +i++ G S G+a++lL++l+
  EFC36539.1  74 RpitiNGGMVMNGWYDIYSlerqelkvhedlegyEASKKLIDELIESQLKQFDSKRIILGGFSQGAAMSLLTGLQ 148
                 2555689***********************99955555556666677999999******************9876 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.6
                 ---EEE-HHHH-GTT-EEEHHHHHHHHS-HHHHHHHHHHHHHHH CS
    Lipase_3  18 dfslteakellekeggkvhsgfleayeeslreqvlkelkrllek 61 
                 ++s    +++ ++e+++ ++ ++ a ++sl ++++ +l++  ++
  EFC36539.1 261 QASS---SKTSHHESYHFNTLMIAASHQSLSSSIHGNLNSHQHR 301
                 3333...3333447899999999999999999999888877665 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0013       3.9      63     111 ..     115     163 ..     103     177 .. 0.78
   2 !   10.2   0.0   0.00011      0.32     188     238 ..     179     232 ..     170     233 .. 0.82
   3 ?   -3.7   0.0         2   5.9e+03     169     210 ..     701     742 ..     690     773 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0013
  Hydrolase_4  63 aafvekvkeehpelplfllGhSmGGliallyllrypdkvaglilsaPal 111
                  ++++e   ++   ++++l G S G++++ll +l+ ++ + ++i ++  +
   EFC36539.1 115 DELIESQLKQFDSKRIILGGFSQGAAMSLLTGLQSKHPLGAIISASGYM 163
                  66778888899999******************99888565555555544 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00011
  Hydrolase_4 188 akitlPllllhGeaDkvvdpeas....relyerlgskdktlklypglyHellnEp 238
                  ++ ++Pl ++hG++D vv+++       + +e+ +s   + k+y    He+ nE+
   EFC36539.1 179 ENKETPLYIFHGDEDDVVHYQSFasesFDWLEKGKS-ITSRKIYRYHSHEVSNEE 232
                  45579**************99766544666677666.99999***99**999995 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 2
  Hydrolase_4 169 tvrlllelldamkrleeraakitlPllllhGeaDkvvdpeas 210
                  +++ l++ ++  ++++++ +++  Pl+l h e+  vv+p+  
   EFC36539.1 701 QIDQLNQQVEFSEKVKQNINDLLGPLILKHHEQGIVVSPNLN 742
                  566677777778888888888888888877777777776554 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0005       1.5      53     112 ..     115     177 ..     105     184 .. 0.84
   2 !    9.2   0.0   0.00026      0.79     138     192 ..     179     232 ..     170     250 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0005
                   HHHHHTT..S--GGGEEEEEETHHHHHHHHHHHH-GGG-SEEEEESE---CCCHHCSTTS.TH CS
  Peptidase_S9  53 ealakeg..yvdserlaitGgSyGGyltgaalnqrpdlFkaavaevpvvdvlrydsdtdl.lt 112
                   ++l++ +  + ds+r+++ G S G  +++ +  q ++  +a++++ + + +++  ++++  + 
    EFC36539.1 115 DELIESQlkQFDSKRIILGGFSQGAAMSLLTGLQSKHPLGAIISASGYMLLRSKFTNPSEfIS 177
                   55655555699*****************************************99999877443 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00026
                   GG-----EEEEEEETT-SSS-THH.HHHHHHHHH--S-S.EEEEEETTS-SSTTSSH CS
  Peptidase_S9 138 dnvkaypplLlihGlaDdrvppae.alklvaaLqkkgkn.vlllifpdegHgvgkpr 192
                   +n  +++pl ++hG++Dd v++++ a + ++ L+k gk  +  +i+    H v++++
    EFC36539.1 179 EN--KETPLYIFHGDEDDVVHYQSfASESFDWLEK-GKSiTSRKIYRYHSHEVSNEE 232
                   45..89****************8735567777776.555588888888888666544 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0     8e-06     0.024      92     162 ..     122     200 ..      92     254 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 8e-06
         DLH  92 vpevstkkvgvvGfCmGGalalllaaev.pevdaavafYG.......lspekeleeaakikapilalfgeeDefipade 162
                  +++++k++ + Gf  G+a++ll   +    + a ++  G        ++++e + +++ ++p+++++g+eD ++  ++
  EFC36539.1 122 LKQFDSKRIILGGFSQGAAMSLLTGLQSkHPLGAIISASGymllrskFTNPSEFISQENKETPLYIFHGDEDDVVHYQS 200
                 345789***************9987766666**************99999999********************998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1010 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1303  (0.0726756); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.87u 0.31s 00:00:01.18 Elapsed: 00:00:00.50
# Mc/sec: 6048.83
//
Query:       EFC36540.1  [L=906]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.2e-24   84.7   0.3    6.2e-24   84.7   0.3    2.6  3  HATPase_c     Histidine kinase-, DNA gyrase B-, and HSP90-lik
    3.8e-10   39.9   0.3    1.7e-09   37.9   0.0    2.3  3  Response_reg  Response regulator receiver domain
    1.2e-09   38.1   0.1      6e-09   35.8   0.0    2.3  2  HisKA         His Kinase A (phospho-acceptor) domain
    1.6e-06   28.0   0.0    4.5e-06   26.5   0.0    1.8  1  PAS_8         PAS domain
    9.8e-06   25.8   0.1      5e-05   23.5   0.0    2.3  2  PAS_9         PAS domain
    0.00036   20.2   0.1     0.0011   18.6   0.1    1.8  1  PAS_12        UPF0242 C-terminal PAS-like domain
    0.00076   19.5   0.0      0.002   18.1   0.0    1.7  1  PAS           PAS fold


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       1.6   4.1e+03       8      43 ..     261     295 ..     259     312 .. 0.74
   2 !   84.7   0.3   2.4e-27   6.2e-24       1     110 [.     332     444 ..     332     446 .. 0.92
   3 ?   -1.7   0.0       1.6   4.1e+03       8      23 ..     517     532 ..     494     595 .. 0.63

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.6
                 HHHHHHHHHHHHHHSTTTEEEEEEEEEETEEEEEEE CS
   HATPase_c   8 qiisnlvdNavkfatkageieveikaseddlvisve 43 
                 +i+sn+++  +   +k ++++ve+++s+ dl+ sve
  EFC36540.1 261 HILSNIIQDVLSS-SKLESGSVELDVSNFDLQYSVE 295
                 7888888888886.6677777777775655555554 PP

  == domain 2  score: 84.7 bits;  conditional E-value: 2.4e-27
                 EHHHHHHHHHHHHHHHHHHHHSTTTEEEEEEEEEE.....TEEEEEEEESSSSSTTHHHTGTCSTTCHHCSTCHTSTSSSHHHHHHHHHHHHTTTEEEE CS
   HATPase_c   1 gdekrLrqiisnlvdNavkfatkageieveikase.....ddlvisveDnGiGipkedlkklfekfsqddstkrggggtGlGlsivkklvelmgGeiwv 94 
                 gd  +++qi+ nl++Na+kf t++g+++v ++++e     +++ + v D+GiGip+e++k lf+ fs+  +++ +++g+GlGlsi+k+l++lm+G+i +
  EFC36540.1 332 GDVHKFQQILTNLMGNAIKF-THTGSVSVLVDVPEetettVKVFVVVCDTGIGIPQEKQKDLFKVFSR-LKKDKEYEGSGLGLSICKNLTTLMNGDIGC 428
                 68889***************.***********94445677889999**********************.888999************************ PP

                 EEETTTEEEEEEEEES CS
   HATPase_c  95 esepgrGttftftlpl 110
                 +s+   G+ f+ft+ +
  EFC36540.1 429 KSNGSSGSNFWFTVVF 444
                 ************9976 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.6
                 HHHHHHHHHHHHHHST CS
   HATPase_c   8 qiisnlvdNavkfatk 23 
                 + i n+  Na+k+++ 
  EFC36540.1 517 ENIENVFVNADKIEQF 532
                 4455666666666433 PP

>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       3.7   9.6e+03       9      35 ..     496     522 ..     494     528 .. 0.74
   2 ?   -2.0   0.0       1.5   3.9e+03       1      19 [.     762     780 ..     762     804 .. 0.82
   3 !   37.9   0.0   6.5e-13   1.7e-09      25     111 ..     805     900 ..     785     901 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.7
                   HHHHHHHHHHHHTTEEEEEEESSHHHH CS
  Response_reg   9 lvrellrqlleeegyeevaeaedgkea 35 
                   +vr++l+++l+e   e+va++e+ +++
    EFC36540.1 496 KVRNILSNYLREVFDEKVATMENIENV 522
                   688899999996666788888887766 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.5
                   EEEESSSHHHHHHHHHHHH CS
  Response_reg   1 vlivdDdplvrellrqlle 19 
                   +l++dD+ ++ +++ +++ 
    EFC36540.1 762 ILVADDNVINKNIMLKIFG 780
                   8999**9999999988775 PP

  == domain 3  score: 37.9 bits;  conditional E-value: 6.5e-13
                   EEEEESSHHHHHHHH.....HHHHESEEEEESSCSSSEHHHHHHHHHHCT....TTSEEEEEESSTSHHHHHHHHHCTESEEEESSG-HHHHHHHH CS
  Response_reg  25 evaeaedgkealell.....keekvdlillDinmpgmdGlellkeireed....pelpviiltahseeedavealkagaddflsKpfdpeeLlkal 111
                   e++ +++gkeal+ +       +k+d i+lD+ m+ m+Gle +++ir  +    p + +i++ a+++++    + +ag+d +  Kp++++++++ +
    EFC36540.1 805 ETKGVSNGKEALDAYienfdTPNKFDAIVLDVHMDVMSGLECAEKIRLFEaekkPATSCILIGATGDSDGESLCKRAGMDLVCLKPISQTQIRNVV 900
                   566789999999988654444445**********************9766556699***********************************99877 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.8   0.0   2.4e-12     6e-09       1      67 []     208     279 ..     208     279 .. 0.90
   2 ?   -2.3   0.0       1.8   4.7e+03      36      63 ..     514     541 ..     501     543 .. 0.81

  Alignments for each domain:
  == domain 1  score: 35.8 bits;  conditional E-value: 2.4e-12
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHC.......T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH CS
       HisKA   1 slgrflagvaHELrtPLsailgnaeaLkre.....gklteelkeyletiesearrldhlvedlLdlsrieag 67 
                 s++ f+++++H+L++PL++i++ a+ + ++        + e  e  + i s+ + l+++++d+L  s++e+g
  EFC36540.1 208 SRTTFFSMISHDLKNPLNSIYLIAQKMHEDfvhqqTVDSHEGLEWMNMILSSCHILSNIIQDVLSSSKLESG 279
                 6899***********************77779877455677777**************************97 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.8
                 SCHHHHHHHHHHHHHHHHHHHHHHHHCC CS
       HisKA  36 elkeyletiesearrldhlvedlLdlsr 63 
                   +e++e +  +a+ +++  e++L  s+
  EFC36540.1 514 ATMENIENVFVNADKIEQFTEEFLHRSS 541
                 5678999999999999999999998776 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.5   0.0   1.8e-09   4.5e-06       2      50 ..      87     136 ..      86     152 .. 0.79

  Alignments for each domain:
  == domain 1  score: 26.5 bits;  conditional E-value: 1.8e-09
       PAS_8   2 rlralfesspdgiavvd.lgd.rivdvNqaalellGys.adlkgellgqllp 50 
                 rl ++++  +++i++   + + +i++vN a+++++Gy+ ++++ +   ++l+
  EFC36540.1  87 RLSNMLNITNEAIIIQSrR-KkKIIYVNLAFERMFGYEhDEIIHASK-NILD 136
                 8999**********97522.358***************888876655.5554 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   1.9e-08     5e-05       2      60 ..      97     174 ..      96     217 .. 0.79
   2 ?   -2.0   0.0       1.6   4.2e+03      39      55 ..     522     538 ..     487     606 .. 0.64

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 1.9e-08
       PAS_9   2 dgili.dnpdgrilyaNeaalrllGyspeevlgks..itdlfvtdpeanerlraaleqgrk................k 60 
                 ++i+i    + +i+y+N a++r++Gy ++e+++ s  i dl+v++p  + +++ + ++ +k                +
  EFC36540.1  97 EAIIIqSRRKKKIIYVNLAFERMFGYEHDEIIHASknILDLLVGPPVIATDKWTLCKARTKigdrfgvevthkvdflS 174
                 67788666777999****************998666688888999999999999999998866555555554444443 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.6
       PAS_9  39 lfvtdpeanerlraale 55 
                 +fv++++ +++ +++l 
  EFC36540.1 522 VFVNADKIEQFTEEFLH 538
                 22333333333333333 PP

>> PAS_12  UPF0242 C-terminal PAS-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.1   4.3e-07    0.0011      53      95 ..      93     135 ..      79     139 .. 0.88

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 4.3e-07
      PAS_12  53 sEnlgailvysqkenkllfaNaqirallGwssdkflqdfseiv 95 
                 + ++ ai++ s++++k++++N  ++++ G+++d++++  ++i+
  EFC36540.1  93 NITNEAIIIQSRRKKKIIYVNLAFERMFGYEHDEIIHASKNIL 135
                 55677899*****************************999997 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   7.8e-07     0.002       6      51 ..      91     139 ..      86     156 .. 0.78

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 7.8e-07
                 HHHHSSSEEEEEE.TTSBEEEECHHHHHHHSSTHHHCTT..SBGGGGBS CS
         PAS   6 ileslpdpifvvD.edgrilyvNaaaeellGlsreevlg..kslldlih 51 
                 +l+ + ++i++   ++ +i+yvN a+e+++G++ +e+++  k++ldl++
  EFC36540.1  91 MLNITNEAIIIQSrRKKKIIYVNLAFERMFGYEHDEIIHasKNILDLLV 139
                 55555555555555***********************973366666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (906 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       917  (0.0511462); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.46
# Mc/sec: 5903.06
//
Query:       EFC36541.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.69   11.1   7.8        7.2    7.8   7.8    2.1  1  DUF3484   Membrane-attachment and polymerisation-promoting sw


Domain annotation for each model (and alignments):
>> DUF3484  Membrane-attachment and polymerisation-promoting switch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   7.8    0.0004       7.2      19      66 ..      77     121 ..      13     122 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0004
     DUF3484  19 PvdpqvqenpqvqeqaqeqPv..........p..skeqeekepkkekltdrvkglFgnmF 66 
                 ++    q+                       +  +++ ee+ep + k  +r++++++ +F
  EFC36541.1  77 TIA--IQP------------SlepnnqqeerDrdYDDDEEEEPDT-KPRSRFRRFISHLF 121
                 222..222............133333333332359999*****99.*************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       899  (0.0501422); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1225.35
//
Query:       EFC36542.1  [L=650]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.056   12.6   0.0      0.095   11.8   0.0    1.5  1  ABC2_membrane_3  ABC-2 family transporter protein
       0.11   12.8   0.0       0.44   10.9   0.0    2.0  1  Wzz              Chain length determinant protein


Domain annotation for each model (and alignments):
>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   1.1e-05     0.095       2      92 ..      96     183 ..      95     302 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.1e-05
  ABC2_membrane_3   2 sfliitlllPiilvlllglifsnsveddentpiavvdednsslsqqlvealeaspsvelvyevdseeeakkalkn.gdidgilvipkgfskd 92 
                      ++l itll+ i+l++ l++++     +++   +++v++++    + l+   ++s+  ++++ v+se+  k+ + + ++ +gil+++k  sk+
       EFC36542.1  96 RTL-ITLLILIFLLASLYFLVVVMM-QQKRRATTLVNPTT--PNSDLNHHEKNSGAANVHNVVKSENVKKHEILEkEKKNGILQVKKKKSKK 183
                      788.777777777777777777666.58888889****94..55677888888888887788888888888886626999****99988864 PP

>> Wzz  Chain length determinant protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   4.9e-05      0.44      15      63 ..      95     144 ..      91     171 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 4.9e-05
                 XXXXXXXXXXXXXXXXXXXX..XXXXX-EEEEEEEES--CHHHHHHHHHCC CS
         Wzz  15 rkklIilvtllfallaviya..flatpkYtataqilvpekkqveassltaq 63 
                 r+ lI l++l+f+l+++ ++  +++++k  at+++ + ++++   +   ++
  EFC36542.1  95 RRTLITLLILIFLLASLYFLvvVMMQQKRRATTLVNPTTPNSD-LNHHEKN 144
                 5677888888888888776666999**************9983.3322222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (650 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3314  (0.18484); expected 358.6 (0.02)
Passed bias filter:                      745  (0.0415528); expected 358.6 (0.02)
Passed Vit filter:                       217  (0.0121033); expected 17.9 (0.001)
Passed Fwd filter:                        55  (0.00306766); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.51u 0.40s 00:00:01.91 Elapsed: 00:00:00.71
# Mc/sec: 2753.86
//
Query:       EFC36543.1  [L=683]
Description: FG-GAP repeat protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.7e-05   25.3   1.4        0.3   11.7   0.0    3.3  3  VCBS        Repeat domain in Vibrio, Colwellia, Bradyrhizobiu
    0.00091   19.3   1.6       0.32   11.2   0.0    2.7  2  FG-GAP      FG-GAP repeat
  ------ inclusion threshold ------
       0.22   11.5   0.3          5    7.2   0.0    3.2  4  PQQ         PQQ enzyme repeat
       0.26   11.5   1.2          8    6.7   0.0    3.4  4  Dockerin_1  Dockerin type I domain


Domain annotation for each model (and alignments):
>> VCBS  Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.1   0.00016      0.71       1      19 [.      60      79 ..      60     108 .. 0.83
   2 ?   -1.7   0.1         1   4.6e+03      50      58 ..     411     419 ..     406     421 .. 0.69
   3 !   11.7   0.0   6.6e-05       0.3       1      22 [.     616     637 ..     594     644 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00016
        VCBS  1 DldgDGrlDlvvan.dgglr 19
                D+dgDG  Dl+ +n +g++ 
  EFC36543.1 60 DIDGDGSKDLITSNdNGRIS 79
                9************9345554 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1
        VCBS  50 DlDgDGdlD 58 
                 D++ DG  D
  EFC36543.1 411 DINFDGMID 419
                 666666655 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 6.6e-05
        VCBS   1 DldgDGrlDlvvandgglrvyr 22 
                 D++gD  lD+vv++ +g++ y+
  EFC36543.1 616 DINGDNILDIVVSTKQGIYAYI 637
                 6777777777777766666665 PP

>> FG-GAP  FG-GAP repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.5    0.0025        11       8      24 ..      59      73 ..      58      79 .. 0.83
   2 !   11.2   0.0   7.2e-05      0.32       6      21 ..     613     628 ..     610     638 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0025
                ESTSSSSS-EEEEEETT CS
      FG-GAP  8 gDvNGDGyaDLavGApe 24
                +D++GDG  DL++   +
  EFC36543.1 59 TDIDGDGSKDLITS--N 73
                6**********998..4 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 7.2e-05
                 EEESTSSSSS-EEEEE CS
      FG-GAP   6 avgDvNGDGyaDLavG 21 
                  ++D+NGD   D++v 
  EFC36543.1 613 QLVDINGDNILDIVVS 628
                 579***********97 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0    0.0011         5      13      33 ..     241     261 ..     241     263 .. 0.86
   2 ?   -0.7   0.0      0.36   1.6e+03      18      25 ..     282     289 ..     281     289 .. 0.87
   3 ?   -2.5   0.0       1.4   6.2e+03      17      27 ..     391     401 ..     377     402 .. 0.81
   4 ?   -3.3   0.0       2.3   1.1e+04      22      29 ..     537     544 ..     536     546 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0011
                 EEEETTTCCEEEEEESSSCGS CS
         PQQ  13 yAlDadTGkvlWrfktggpvl 33 
                 + lD +TG+++W+++ +++ +
  EFC36543.1 241 FCLDGATGQLRWKHQSNAKSW 261
                 579**********99888776 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.36
                 TTCCEEEE CS
         PQQ  18 dTGkvlWr 25 
                 d+G+v+Wr
  EFC36543.1 282 DSGEVIWR 289
                 78*****7 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 1.4
                 TTTCCEEEEEE CS
         PQQ  17 adTGkvlWrfk 27 
                 ++TG+ l +f 
  EFC36543.1 391 LYTGRTLTQFS 401
                 68999999996 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 2.3
                 EEEEEESS CS
         PQQ  22 vlWrfktg 29 
                 v+W++ t+
  EFC36543.1 537 VKWQVMTP 544
                 89**9987 PP

>> Dockerin_1  Dockerin type I domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.77   3.5e+03      37      44 ..      59      66 ..      56      70 .. 0.71
   2 ?   -0.6   0.1      0.35   1.6e+03       5      41 ..      73     110 ..      72     113 .. 0.79
   3 ?    6.7   0.0    0.0018         8      32      56 ..     405     429 ..     391     431 .. 0.81
   4 ?    0.0   0.0      0.22     1e+03      27      43 ..     605     621 ..     585     624 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.77
                GSTT-SSC CS
  Dockerin_1 37 aDvNgDGr 44
                +D++gDG+
  EFC36543.1 59 TDIDGDGS 66
                57777775 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.35
                 TSSSC-SHHHHHHHHHHCT.SSEBTTSCCCHGGGSTT- CS
  Dockerin_1   5 NgDgkVnalDalliinyln.qregqssssngkaaDvNg 41 
                 N++g+++   +  i   l+  ++  +  +++k +DvN+
  EFC36543.1  73 NDNGRISIVSLKTISSSLLvHQDMFNPITEEKSFDVNE 110
                 88888888888888888887777777888889999995 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0018
                 CCHGGGSTT-SSCESHHHHHHHHHH CS
  Dockerin_1  32 sngkaaDvNgDGrvnalDallviny 56 
                 +n+ + D+N DG ++a  a++ + +
  EFC36543.1 405 ENTYYQDINFDGMIDAAEAQVCKAR 429
                 5667889999999999999877665 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.22
                 BTTSCCCHGGGSTT-SS CS
  Dockerin_1  27 gqssssngkaaDvNgDG 43 
                 + +s s+ +  D+NgD+
  EFC36543.1 605 PHPSISPIQLVDINGDN 621
                 55666788889999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (683 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1096  (0.06113); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 3958.74
//
Query:       EFC36544.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.027   14.6   1.0      0.027   14.6   1.0    2.7  3  FliE        Flagellar hook-basal body complex protein FliE


Domain annotation for each model (and alignments):
>> FliE  Flagellar hook-basal body complex protein FliE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   1.4    0.0082   1.5e+02      26      70 ..      48      92 ..      35      94 .. 0.79
   2 ?   14.6   1.0   1.5e-06     0.027      12      55 ..      95     138 ..      87     145 .. 0.89
   3 ?   -1.3   0.1      0.14   2.4e+03      27      42 ..     145     160 ..     139     161 .. 0.71

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.0082
        FliE 26 saleevnetqkeaeelaeafalGesvdlhdvmialqkAslslqlt 70
                +++e+ n++ k+a++ + +  +  +++ + ++ ++q As+++ + 
  EFC36544.1 48 DSVEKSNAKGKSANTNSSSSSSTTNTSGKGATENSQRASTTMGYS 92
                678888888888888888888888888888888888888888765 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1.5e-06
        FliE  12 aaaasaesFasvLksaleevnetqkeaeelaeafalGesvdlhd 55 
                 +++++++ F ++Lk+  +++ + +ke e+ a+++a+ +++dlh 
  EFC36544.1  95 EQESNSGAFPDALKEEYNKMMKINKEEEQRAASLASSQKDDLHT 138
                 4555666***********************************96 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.14
        FliE  27 aleevnetqkeaeela 42 
                 ++++v + q++ ++++
  EFC36544.1 145 TINDVRNEQQAEHNKQ 160
                 5778877777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2413  (0.134586); expected 358.6 (0.02)
Passed bias filter:                      589  (0.0328518); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 1013.05
//
Query:       EFC36545.1  [L=1086]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-48  165.6   0.0      2e-48  164.8   0.0    1.4  1  NAD_binding_4  Male sterility protein
    1.8e-29  102.6   0.0    2.8e-29  102.0   0.0    1.2  1  AMP-binding    AMP-binding enzyme
    7.6e-13   48.5   0.0    1.7e-12   47.3   0.0    1.6  1  Epimerase      NAD dependent epimerase/dehydratase family
    1.4e-12   47.2   0.0    3.5e-12   45.9   0.0    1.7  1  3Beta_HSD      3-beta hydroxysteroid dehydrogenase/isomerase 
      4e-11   43.1   0.1    2.4e-09   37.4   0.0    2.5  2  PP-binding     Phosphopantetheine attachment site
  ------ inclusion threshold ------
      0.082   12.4   0.0        0.2   11.2   0.0    1.6  1  ERAP1_C        ERAP1-like C-terminal domain


Domain annotation for each model (and alignments):
>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  164.8   0.0   6.7e-52     2e-48       1     257 []     719     955 ..     719     955 .. 0.88

  Alignments for each domain:
  == domain 1  score: 164.8 bits;  conditional E-value: 6.7e-52
                    EE-TTSHHHHHHHHHHHHHS-.TEEEEEE-SSSHHHHHHHHHHHT-SS-HHHHHHHHHTTTEEEEE--TTSGGGG--HHHHHHHHHH--EEEE--S CS
  NAD_binding_4   1 lTGaTGFLGkvLlekLLrttpevkiyllvRaksgesaeeRleeelekkelfsallkelaerikvveGDlseprlGLseedlqelaeevdviihsaA 96 
                    lTG+TGFLG++Ll++LL+ ++   +y+ +R +s ++a++Rl ++++k++l+++++    +r++v++GD+  + +G++ ++++ela++vdv++h + 
     EFC36545.1 719 LTGSTGFLGAFLLRDLLELQELKMVYCICRGNSIDHATKRLIDNMKKYSLWKNEY---ISRVQVLVGDVGLDLFGMDRATYDELARNVDVVYHGGS 811
                    8******************9855*******************************8...************************************** PP

                    S-S.STTSSEEHHHHHHHHHHHHHHHTSSS--.-EEEEEE.GGGTTS-TTT--SSS-H......HHH--EEEETTTCCCHHHHHHHHHHHHHHHHH CS
  NAD_binding_4  97 tvnfdepykellrvNveGtrevlelakklkklkvllhvST.ayvngeregeveekvyeegekeekldederaklkglpntYeqsKalaEklvrear 191
                     vnf +p + l++ Nv+Gtr+++e++ + + + +ll+vS+ +++  ++ +             +  +  +  ++ +l+ +Y q+K+++E l+++a+
     EFC36545.1 812 VVNFIQPFSSLKESNVDGTRRMIEFSFQSRVK-PLLYVSSiSAAPLDKDSG------------QPIERISTLSEMNLTFGYPQTKFASECLLKQAK 894
                    ***************************99999.*******84444444322............3477888999999******************** PP

                    HHH---EEEEEE-EEE--SSST---TTSHHHHHHHHHHHH-EEES-SB---TT--EEEHHHHHHHH CS
  NAD_binding_4 192 rrsglpvvivRpsiitgesktGwingsdlgirgllgliakgvlpeilgdkeavldlvpvDyvanai 257
                    +  glp++ivRp+ i+g  +tG + +  l+ r+l+++ +++  p    + e v +lv vD+v+++i
     EFC36545.1 895 DILGLPILIVRPGLIIG-NETGEMPKGFLLERMLKSIKRTNSTP----NLEIVRNLVNVDFVSKII 955
                    *****************.56777777774555555555555555....555668********9875 PP

>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  102.0   0.0   9.5e-33   2.8e-29      21     327 ..      62     388 ..      49     411 .. 0.76

  Alignments for each domain:
  == domain 1  score: 102.0 bits;  conditional E-value: 9.5e-33
                  EEEEHHHHHHHHHHHHHHHH.HT..TSSTT-EEEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHHTESEEEETCTCCCHHHHHHHHS CS
  AMP-binding  21 qtlTYreldervnrlAagLr.sl..GvkkgdrVaillpnspewvvallailkaGavvvplnptltaeelayiledseakvliatvdselleklleaaa 115
                   tlT++++ + v  +A+ L  +    +kkg++Va+l +ns+ + v+l+a++ +G++  p+n++lt+  ++ +le  ++k++    + + l+++ +a +
   EFC36545.1  62 STLTFGQFSKSVA-MARRLImKQwpSLKKGSCVALLHENSIVYSVLLFALWTLGCINFPVNNKLTPGIISKLLELGNVKYVS--LSPQILDSMIKASD 156
                  6899999998886.5666664544589*******************************************************..55555555555555 PP

                  CC-EECEEEEESCCS-HCCHCCCHCCCCSCTTS..........................-TSCCCS-BTTSEEEEEEE--SSSS-EEEEEEHHHHHHH CS
  AMP-binding 116 kleavklvivldadellkeeelkeeeeseekae..........................kpeeeeelkpddlayiiYTSGTTGkPKGVmlshrnlvan 187
                  k+ + +    + ++ + +++ +++ ++ e+ ++                          k+  + + k +d+++ + TSG+T  PK V++  r+l+++
   EFC36545.1 157 KESMDTF-FKTADKYMITSDISQQLKDYEKHEYssylkpfdiisaikdqldttisdedlKQALKLPFKFEDPCFYLNTSGSTNIPKIVIHNMRSLMSS 253
                  4433333.3333334444444444444443332455777889999999999999999994445557899***************************** PP

                  HHHHHHHHCSCCTTT-EEEESS-TTSCHHHHHHHHHHHHTT-EEEE-TTCGCCH.HHHHHHHHHHHT....-SEEEEEHHHHHHHHHCCCHHCHHHHC CS
  AMP-binding 188 vaslkletrfklkeddvvlsilplahifglilelllallsGatvvllpkdaald.pklllelieklk....vtviagvPrvleallesgalkaakkak 280
                  ++  +     ++++++ v+ +lpl+h +gl ++ll++l++G   ++++++++ + +++l +++  +k     t   + P +le ++es++++     k
   EFC36545.1 254 LHYSQ---SIGTTSQQYVINFLPLFHLMGL-YNLLGCLYKGTNYIMFNQTTRQSiSQTLSQVLLSHKehlpSTRAIVFPILLEEIMESEEKT-----K 342
                  88854...4445567789***********9.*****************99996666666555544441111555666677777778854333.....4 PP

                  CGTT-SEEEEESS-EBHHHHHHHHHHHTCEEEEEEEEGGGSSECEEC CS
  AMP-binding 281 dlsslrlvllggeplspellrffralfgeevlegYGlTEttgvvtvl 327
                   ls   +v lgg + + +l+  ++++ ++ + +gYG++E ++v++ +
   EFC36545.1 343 LLSECLVVALGGVSTPNHLINYCQDHRIN-ITNGYGMSEVGVVMAAD 388
                  7777666678**********999999887.*************9743 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.3   0.0   5.7e-16   1.7e-12       1     197 [.     717     934 ..     717     952 .. 0.80

  Alignments for each domain:
  == domain 1  score: 47.3 bits;  conditional E-value: 5.7e-16
                 EEEETTTSHHHHHHHHHHHHCT.SE.EEEEES-STTTTCHHCHHC.......................EEEE--TT-HHHHHHHHHHHT-SEEEE--S- CS
   Epimerase   1 ilVtGatGfiGsalvkallekg.ye.vigldrlssasntarledl.......................elveldltdrsalerlfkeeqpdavihlAav 74 
                 +l+tG tGf+G+ l++ lle +  + v ++ r  ++  +a ++ +                          +l  +dr+  ++l +  ++d+v+h    
  EFC36545.1 717 VLLTGSTGFLGAFLLRDLLELQeLKmVYCICRG-NSIDHATKRLIdnmkkyslwkneyisrvqvlvgdVGLDLFGMDRATYDELAR--NVDVVYHG--- 809
                 699*****************9985547777777.44444444444678**************888866334444466777777777..89*****9... PP

                 --HHHHHHSH.HHHHHHHTHHHHHHHHHHHHHTCTEEEEEEEGGGGTSCSS..SSBSTCSTTS----SSHHHHHHHHHHHHHHHHHHHHT-EEEEEEES CS
   Epimerase  75 ggvaassedp.adfieknlqgtlnlleaarkagvkrllflsSsevYGkdae..qpkeettltgplkpnspYaaaKlageklveayaaqyglnaiilrlf 170
                  g  +++++p + + e+n+ gt++++e ++++ vk ll++sS +  + d++  qp e  +  ++++ +  Y  +K a+e l++++++  gl+++i+r+ 
  EFC36545.1 810 -GSVVNFIQPfSSLKESNVDGTRRMIEFSFQSRVKPLLYVSSISAAPLDKDsgQPIERISTLSEMNLTFGYPQTKFASECLLKQAKDILGLPILIVRPG 907
                 .344444444145556**************************99999777766898888878999********************************** PP

                 EEESTTS-TTSTTSHHHHHHHHHHTTS CS
   Epimerase 171 nlyGprngegevsrvipalirkilegk 197
                  ++G  +ge     ++ +++++i++  
  EFC36545.1 908 LIIGNETGEMPKGFLLERMLKSIKRTN 934
                 ******666667777888888887755 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.9   0.0   1.2e-15   3.5e-12       2     226 ..     719     956 ..     718     967 .. 0.78

  Alignments for each domain:
  == domain 1  score: 45.9 bits;  conditional E-value: 1.2e-15
   3Beta_HSD   2 vtGgaGFlGralvkeLvrleelkevrvlD............lrespelleelskvnvkk........viegDv......tdkdkleealegvdvvihla 74 
                 +tG++GFlG+ l + L++l+elk v  +             +       ++++k    k        v+ gDv      +d ++ +e  ++vdvv h  
  EFC36545.1 719 LTGSTGFLGAFLLRDLLELQELKMVYCICrgnsidhatkrlI-------DNMKKYSLWKneyisrvqVLVGDVgldlfgMDRATYDELARNVDVVYHGG 810
                 79***********************88776777545555441.......33333332222333345588999964445557778888889999999998 PP

   3Beta_HSD  75 slvdvagkltedeimkvnvkGTrnvleacvkagvrvlvYtSsaevv.gpnslgeeilngdEeleyeslhqdaypesKalaEklvlkaNgrtlknggrly 172
                 s+v+  +   + ++ + nv GTr ++e  +++ v+ l+Y+Ss++++  +   g++i     ++  e + +  yp++K  +E l+++a +     +  l 
  EFC36545.1 811 SVVNFIQ--PFSSLKESNVDGTRRMIEFSFQSRVKPLLYVSSISAApLDKDSGQPIE--RISTLSEMNLTFGYPQTKFASECLLKQAKD-----ILGLP 900
                 8888876..89999******************************9934667899999..5567777777788***************99.....44588 PP

   3Beta_HSD 173 TcaLRpagiyGegdkllvp..llkqlaklglalfkigdeevlsdrvYvgNvawahi 226
                    +Rp  i G+   ++ +  ll++++k+ +   ++ + e++ + v v+ v+++++
  EFC36545.1 901 ILIVRPGLIIGNETGEMPKgfLLERMLKSIKRTNSTPNLEIVRNLVNVDFVSKIIV 956
                 88999999999987776552267889999888888888899999999988888777 PP

>> PP-binding  Phosphopantetheine attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0      0.04   1.2e+02      36      56 ..     196     216 ..     195     219 .. 0.90
   2 !   37.4   0.0     8e-13   2.4e-09      14      67 .]     624     677 ..     610     677 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.04
  PP-binding  36 ellaaleeefgveiplsdlfe 56 
                 ++++a++++++++i+++dl +
  EFC36545.1 196 DIISAIKDQLDTTISDEDLKQ 216
                 6899***************76 PP

  == domain 2  score: 37.4 bits;  conditional E-value: 8e-13
  PP-binding  14 pleeidpdtdlfdlGlDSllavellaaleeefgveiplsdlfehptlaelaayl 67 
                 ++ +i+++t+l + GlDS+++++l + ++ ef+v++++++++  +t++ l++++
  EFC36545.1 624 EENAIELNTSLTNIGLDSISLIKLRNYIKNEFNVQLSVDEVYKMNTPKKLIEAI 677
                 344599********************************************9986 PP

>> ERAP1_C  ERAP1-like C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   6.7e-05       0.2     228     297 ..     962    1029 ..     928    1045 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6.7e-05
                  -GGGHHHHHHHH..HSTTHHHHHHHHHHHCHCCHHHHTSSTSCHHHHHHHHHTT--SHHHHHHHHHHHCHT CS
     ERAP1_C  228 rnqdlrallagl.annpegrellwefvkenwdalakrwsggeildrivkgllpgftseeelaeieaffadk 297 
                  +  dl++  + + ++np+++e+l++ +k+n+ +l+ + +  +++d+++++++++  s++    ++++ ++ 
  EFC36545.1  962 KLFDLEI--IHIcNTNPPTHEELLNHLKTNYPNLYGKVEE-TSFDNFLSNVTENDKSDDGMYPLSQWAKET 1029
                  3334444..4555679**********************84.68**********999999888888887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1086 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       724  (0.0403815); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.79u 0.33s 00:00:01.12 Elapsed: 00:00:00.48
# Mc/sec: 6762.39
//
Query:       EFC36546.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.4e-40  137.7   0.2    5.3e-40  137.4   0.2    1.1  1  DNA_alkylation  DNA alkylation repair enzyme
  ------ inclusion threshold ------
      0.081   12.3   0.1       0.13   11.7   0.1    1.2  1  Rab5-bind       Rabaptin-like protein


Domain annotation for each model (and alignments):
>> DNA_alkylation  DNA alkylation repair enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.4   0.2   5.9e-44   5.3e-40       1     213 []      12     250 ..      12     250 .. 0.89

  Alignments for each domain:
  == domain 1  score: 137.4 bits;  conditional E-value: 5.9e-44
  DNA_alkylation   1 ikaeLealadpekaeemqryfkegdeflGvkvpelrklakeffkelkle.....eelqelaeeLwksperEerllAldlltqak....kklaea. 85 
                     ++++L ++a+++ a++++ y+k+  +f+G+k+p ++k  k+ +k+  +      ++  ++  eL++s+++Ee+ +++++l        +    + 
      EFC36546.1  12 VRTTLLKVANKDSAKHQEGYMKNVIKFHGLKAPIVEKCWKDTLKSNLQTnipelKDQVDVSYELIASKYFEEKSIGIKILASNVknfvP----Kk 102
                     578999***********************************8887555469666555577779*****************887744441....23 PP

  DNA_alkylation  86 ................dlelyeklve...tinnWdlvDslaskivgalladkperrdllkeWaksenlWerRaAivatlklikk.tdlellleia 160
                                     +++ +e+++    ++  W+++D++ s+++ +l++++ +  +++++W  s+nlW++R A+v+++k +k+ +  +l+++i+
      EFC36546.1 103 kkksteddeigvnglyVVNGIEENLFdkeHVYDWATCDTISSTVICELIKRDSSLAQVVQKWKDSDNLWKQRSACVSFVKIAKHgEYNDLIIDIC 197
                     4446789*********99999998864568899***************************************************44455678*** PP

  DNA_alkylation 161 eelladkedfiqkAiGwaLrelsktdpdlveeFlekhakrmprlslreAiekl 213
                      ++++++e f q ++Gw+Lrels  d dlv++F+++++++++r  lr+A+ek+
      EFC36546.1 198 STTVKNSERFAQLGTGWVLRELSLADLDLVTDFIKENYSHFSREGLRYAVEKM 250
                     ***************************************************97 PP

>> Rab5-bind  Rabaptin-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   1.4e-05      0.13     158     237 ..      20      98 ..      10     113 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.4e-05
   Rab5-bind 158 esRtakdHlEekLkaEill..LkeqiqaEkalkEnlEetlqleierlkeelasisslkveleeikvekeslekslaektrql 237
                 + + ++ H E  +k+ i +  Lk+ i  Ek+ k+ l + lq++i +lk++++   s  + +++   ek    k la + +++
  EFC36546.1  20 ANKDSAKHQEGYMKNVIKFhgLKAPIV-EKCWKDTLKSNLQTNIPELKDQVDV--SYELIASKYFEEKSIGIKILASNVKNF 98 
                 5567899********999988999996.8***********************9..777777777777766556666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       840  (0.0468515); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 1699.50
//
Query:       EFC36547.1  [L=657]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-85  279.9  49.6    2.8e-13   49.4   0.0   14.5 15  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.5   0.0     6e-12   1.1e-07       4      49 .]       8      53 ..       5      53 .. 0.96
   2 !   34.0   0.0   9.8e-13   1.8e-08       1      36 [.      30      65 ..      30      70 .. 0.95
   3 !   42.6   0.4     2e-15   3.7e-11       1      49 []      55     104 ..      55     104 .. 0.95
   4 !   31.0   0.1   8.8e-12   1.6e-07       2      43 ..     107     148 ..     106     154 .. 0.87
   5 !    5.2   0.1   0.00098        17      20      38 ..     150     168 ..     148     180 .. 0.80
   6 !   15.3   0.2   6.9e-07     0.012       1      48 [.     156     202 ..     156     203 .. 0.92
   7 !   16.5   0.9   2.9e-07    0.0053       1      48 [.     181     252 ..     181     266 .. 0.92
   8 !   17.1   0.1   1.9e-07    0.0034       2      36 ..     280     314 ..     279     347 .. 0.88
   9 !   15.1   0.2     8e-07     0.014       1      32 [.     361     392 ..     361     396 .. 0.90
  10 !   11.5   0.2     1e-05      0.18      16      38 ..     399     421 ..     394     425 .. 0.86
  11 !   17.9   0.3   1.1e-07    0.0019      17      49 .]     426     458 ..     420     458 .. 0.96
  12 !   44.1   0.6     7e-16   1.2e-11       1      49 []     460     509 ..     460     509 .. 0.94
  13 !    6.4   0.1   0.00041       7.4      19      45 ..     504     530 ..     499     533 .. 0.84
  14 !   49.4   0.0   1.5e-17   2.8e-13       1      49 []     535     583 ..     535     583 .. 0.98
  15 !   17.4   0.2   1.5e-07    0.0028       1      46 [.     585     630 ..     585     633 .. 0.89

  Alignments for each domain:
  == domain 1  score: 31.5 bits;  conditional E-value: 6e-12
     DUF4116  4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                +++ +v++n ++lky+++ +k D+++v  A+k  + a+ ++se Lr
  EFC36547.1  8 VIKLLVSHNAYVLKYAPSHWKDDRQVVELAIKHAPLAFQFCSERLR 53
                7999***************************************998 PP

  == domain 2  score: 34.0 bits;  conditional E-value: 9.8e-13
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36
                Dr++v  a+k+ ++a++++se+L+ D+eivl A+ +
  EFC36547.1 30 DRQVVELAIKHAPLAFQFCSERLRDDREIVLMACSK 65
                9********************************986 PP

  == domain 3  score: 42.6 bits;  conditional E-value: 2e-15
     DUF4116   1 DrEivleavkkngs.alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivl a++k  +  ++++se+LknD  iv+ A++++g+++s ++e+L+
  EFC36547.1  55 DREIVLMACSKKYFsGFEFISERLKNDETIVKLAIESDGFNYSKIPEHLK 104
                 9*********887559********************************97 PP

  == domain 4  score: 31.0 bits;  conditional E-value: 8.8e-12
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 ++i+l a++ +g+++ yl++eLk+D++i ++A+ +ng +   
  EFC36547.1 107 KDIALLALSVYGYIFDYLPNELKRDIDIRIAACLSNGLNVGI 148
                 89***********************************75443 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.00098
     DUF4116  20 seeLknDkeivlkAvkqng 38 
                  +e+k +keivl+  +  +
  EFC36547.1 150 YPEIKDNKEIVLELAQHGK 168
                 6899********9887544 PP

  == domain 6  score: 15.3 bits;  conditional E-value: 6.9e-07
     DUF4116   1 DrEivleavkkngsalky..lseeLknDkeivlkAvkqngtalsyaseeL 48 
                 ++Eivle+ ++  +++ +  + ++L  D +i+ ++vk +g++lsy++ +L
  EFC36547.1 156 NKEIVLELAQHGKLNYLKagVYKSL--DLDIIEECVK-SGISLSYLPSDL 202
                 79*********99999995668999..**********.*********998 PP

  == domain 7  score: 16.5 bits;  conditional E-value: 2.9e-07
     DUF4116   1 DrEivleavkkngsalkylseeLkn.........................DkeivlkAvkqngtalsyaseeL 48 
                 D +i+ e+vk+ g +l yl+++L +                         D +i+lkA+  n++ l+y++ +L
  EFC36547.1 181 DLDIIEECVKS-GISLSYLPSDLICerkdlllivlenhpyghikntkhalDYDILLKAISGNSNHLKYVPVDL 252
                 89*********.899*******988888999999999999999999999999****************99765 PP

  == domain 8  score: 17.1 bits;  conditional E-value: 1.9e-07
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 +++++ ++ +ngs+++yl ++  nD+ei+l +++ 
  EFC36547.1 280 KQVAKTLIARNGSSIYYLEKSCFNDREILLSCLRV 314
                 78999***************************994 PP

  == domain 9  score: 15.1 bits;  conditional E-value: 8e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 +r ++l+ v  +  +++ lse+L nDke+v++
  EFC36547.1 361 NRSLILKMVPEFEVSIYELSEDLWNDKEVVMQ 392
                 67889999999999*****************9 PP

  == domain 10  score: 11.5 bits;  conditional E-value: 1e-05
     DUF4116  16 lkylseeLknDkeivlkAvkqng 38 
                 +k+l++ ++nDke++l+ +k  +
  EFC36547.1 399 YKKLPKHIRNDKEVLLAYIKYKP 421
                 788**************999876 PP

  == domain 11  score: 17.9 bits;  conditional E-value: 1.1e-07
     DUF4116  17 kylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 k+l++eL +D ++++k +k +++a++++ +eL+
  EFC36547.1 426 KFLNPELVKDLDFLKKVLKYSPNAYKFLTPELK 458
                 799****************************97 PP

  == domain 12  score: 44.1 bits;  conditional E-value: 7e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsyaseeLr 49 
                 Dr ++ e+v++n++ +k+l+++++nD+e+++ +vk++g + l+ ++e+Lr
  EFC36547.1 460 DRNLIFEIVENNPCLFKFLDSSFRNDRELIMMIVKKYGtDHLDVIPESLR 509
                 9*************************************446999999998 PP

  == domain 13  score: 6.4 bits;  conditional E-value: 0.00041
     DUF4116  19 lseeLknDkeivlkAvkqngtalsyas 45 
                 ++e+L+ Dke++   v+++ ++++ ++
  EFC36547.1 504 IPESLRADKELIWSSVEKSADFFNKYP 530
                 8***********999999988887666 PP

  == domain 14  score: 49.4 bits;  conditional E-value: 1.5e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+ l+avk++++ l+y+++ L+ D+e+++ A+k++g al++as+ L+
  EFC36547.1 535 DRELLLHAVKHYPYTLQYADPPLCDDFEVIMTACKNSGMALKFASPRLK 583
                 9*********************************************986 PP

  == domain 15  score: 17.4 bits;  conditional E-value: 1.5e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 + +iv+ a+ ++ +a+  +s+ Lk D+ +++ A+  n +++ ++ +
  EFC36547.1 585 NPDIVKAAILSYEYAFSDASPFLKEDFMFCISALLCNHSSIHFVND 630
                 689******************************9877777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (657 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       574  (0.0320152); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 3975.93
//
Query:       EFC36548.1  [L=514]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.062   13.2   0.1       0.13   12.1   0.1    1.6  1  Phage_30_8  Phage GP30.8 protein


Domain annotation for each model (and alignments):
>> Phage_30_8  Phage GP30.8 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.1   7.5e-06      0.13      47     120 ..     108     181 ..      93     184 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.5e-06
  Phage_30_8  47 sddftytievenfftgeiyrlnsvvv...gkirsktyedeelgesedvvwyetarnraesliekikkkgkldsakwk 120
                   +ft +++ +nff g  yrln+ +      i+ + + d++lg    +  ++  +    s+   ikk  + ds+++ 
  EFC36548.1 108 CREFTSEVDTRNFFLGICYRLNAEIAildKEIKENIMIDKNLGS---LFCFNVVKTGNSSFTSSIKKLLVRDSNQYL 181
                 56899*****************9764122457777777777776...555556666666666777776666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       634  (0.0353617); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2975.06
//
Query:       EFC36549.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.093   12.3   0.4       0.13   11.8   0.4    1.2  1  DUF533    Protein of unknown function (DUF533)
        0.1   12.7   0.0       0.18   11.9   0.0    1.3  1  DUF5065   Domain of unknown function (DUF5065)
          7    6.5   5.5        2.7    7.9   0.1    2.4  2  B12D      NADH-ubiquinone reductase complex 1 MLRQ subunit


Domain annotation for each model (and alignments):
>> DUF533  Protein of unknown function (DUF533)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.4   2.2e-05      0.13      26      74 ..      96     150 ..      87     152 .] 0.55

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.2e-05
      DUF533  26 kkalklGglAalGglAykayq.nwqanqqeaapqsapkfq......eeeeekaell 74 
                 ++    G+lA++G++ + a+  ++++n++ +++q++ + q      e+ee+++e l
  EFC36549.1  96 GNGSFWGALAVVGAVSLGAMYvATNNNNPPNQQQQQIQ-QqgrrnnENEESQQECL 150
                 5556679********99887733333333222222222.11222223666666655 PP

>> DUF5065  Domain of unknown function (DUF5065)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0     3e-05      0.18       4      44 ..     102     142 ..     100     150 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3e-05
     DUF5065   4 gklalvGaLalGgltavetlqakpsaaaatvqaasavlddw 44 
                 g la+vGa +lG++  +   +  p+ + +++q++ + +++ 
  EFC36549.1 102 GALAVVGAVSLGAMYVATNNNNPPNQQQQQIQQQGRRNNEN 142
                 789**********9877777777999*******99988864 PP

>> B12D  NADH-ubiquinone reductase complex 1 MLRQ subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.1   0.00045       2.7      27      47 ..       3      21 ..       2      35 .. 0.84
   2 ?   -0.6   2.2       0.2   1.2e+03      11      27 ..     105     121 ..     103     146 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00045
        B12D 27 lltnPDVrwnkknnpepWnkl 47
                + ++PDV+w++++++   +kl
  EFC36549.1  3 INYSPDVVWRNQKRKL--QKL 21
                5689*********997..665 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.2
        B12D  11 figagvggavfylvRll 27 
                 ++ ++v++ ++y++ + 
  EFC36549.1 105 AVVGAVSLGAMYVATNN 121
                 56666666666666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1323  (0.0737911); expected 358.6 (0.02)
Passed bias filter:                      666  (0.0371465); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.46u 0.33s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 949.66
//
Query:       EFC36550.1  [L=534]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (534 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       836  (0.0466284); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 3434.08
//
Query:       EFC36551.1  [L=220]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      6e-06   26.5   5.0    8.3e-06   26.1   5.0    1.3  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   5.0   4.6e-10   8.3e-06       2      84 ..      76     167 ..      75     205 .. 0.84

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 4.6e-10
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHH...HHHHHCSS......S CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklree...lekrleke......q 84 
                 les l++q+ r l re++ +e s en +F+    e+k +++++  ++ ++eI + yl+++s+ elni++ +r++   l+kr++++      +
  EFC36551.1  76 LESYLKHQDFRDLIREYCVKELSLENYNFFTFLLELKLKSKKKLSIELMDEISQVYLNQNSTFELNISSTCRKNffiLRKRIQDQnetelsT 167
                 78899**********************************888888899************************98444566666654444432 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1185  (0.066094); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 1468.04
//
Query:       EFC36552.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   11.8   0.0       0.22   11.0   0.0    1.5  1  YhfZ_C    YhfZ C-terminal domain


Domain annotation for each model (and alignments):
>> YhfZ_C  YhfZ C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   1.2e-05      0.22      10      71 ..      73     132 ..      64     158 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.2e-05
      YhfZ_C  10 glrnlvgamPlpyskkyeGLatglkaafeklgiplnlaymrGadkRlealkegrydfavvSr 71 
                 + +nl+ +  +p s k++ L t l++ f+++ i   + +++G  +R+  l+   +d++++Sr
  EFC36552.1  73 KQHNLLDIAFIPASLKMSTLWTKLNSDFNQKRIVNFYGFVKGYGQRFHILE--DFDMIITSR 132
                 5566666666899*******************99999************97..59******8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.42
# Mc/sec: 1770.86
//
Query:       EFC36553.1  [L=140]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.2e-16   58.3   0.0    7.1e-16   58.1   0.0    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.1   0.0   3.9e-20   7.1e-16       3     120 ..      11     124 ..       9     125 .. 0.90

  Alignments for each domain:
  == domain 1  score: 58.1 bits;  conditional E-value: 3.9e-20
                  HHHHHHCTTT.SSEEEEEEECTTTEEEEEESS-.HHHHHHHHHHTTT-EEEEEEEEEECCSECCEEEEEEEEE--TTS-HHHHHHHHHHHHHHHHHCT CS
  Cofilin_ADF   3 eafkelksgkktkyilfkidddkeeivveeege.tyeelreelpeseprYavydveyehddeskrsklvfIswvPdsapikqkmlyasskdalkkelk 99 
                  +a+++lk ++ +k++ f  +  k+ ++++++g+ +++e++ ++  s++ +++y+    +d  s r+k+v+++w++++++ +++ ++a++k+ + ++  
   EFC36553.1  11 AAWESLKTES-IKWFTFVPE--KTGLIMDATGTgDWDEFLGSFGPSDVKFGIYRAVAVDD-DSRRTKFVLVAWTGSQCNAMKRSKVAANKTIVTQKY- 103
                  6788888866.999999776..568*****999**********999********875555.5***********************************. PP

                  TSEEEEEE-CGGCCSHHHHHH CS
  Cofilin_ADF 100 gisveieatdldelteeelke 120
                   ++++i+a++   l++ee+  
   EFC36553.1 104 SVHIDIQASEHAQLSQEEVIA 124
                  9****************9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (140 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.25s 00:00:00.68 Elapsed: 00:00:00.42
# Mc/sec: 993.56
//
Query:       EFC36554.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.8e-11   44.4   0.0    2.4e-11   44.0   0.0    1.1  1  Cyclase    Putative cyclase
  ------ inclusion threshold ------
      0.065   13.2   0.0       0.12   12.4   0.0    1.4  1  TetR_C_13  Tetracyclin repressor-like, C-terminal domain


Domain annotation for each model (and alignments):
>> Cyclase  Putative cyclase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.0   2.7e-15   2.4e-11      19     136 .]      23     142 ..       5     142 .. 0.76

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 2.7e-15
     Cyclase  19 slsehtGTHlDapgHfaektide.lpleelvgpavvldvsakaaaedyeiitaedleaalakqgveikpgdi..vlirTgwskrledkeky..rnpgls 112
                   ++h+GTH D p Hf ++ i e     ++ g ++vl++ ++ + ++ ei ++e l++a++k++  i++ +i   +i+T  ++  +d++++  +   ++
  EFC36554.1  23 LSNSHAGTHADQPKHFEKNPIVEyFHTLQYNGACLVLNLVEELK-NNLEI-SEEILRNAIEKSK--IPKDKIlrCIIKTRSNQP-SDEQEWtnDFAHFH 116
                 4578************8865655222334666777777744322.46655.*********9998..777777447999977665.778899666699** PP

     Cyclase 113 eeaaewlaekg..vkavGvDtlsvDa 136
                 ++aae+l ++   + ++G+Dt+s+D+
  EFC36554.1 117 PSAAEYLSRELpnLLLIGIDTPSIDH 142
                 *********987799*********96 PP

>> TetR_C_13  Tetracyclin repressor-like, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.3e-05      0.12      18      82 ..      48     115 ..      36     120 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.3e-05
                 HTTTT----HHHHHHHTGGGS-TTHHHHHHHHHHHH...HHHHHHHHHHHHCTTSS-TTS-HHHHHHH CS
   TetR_C_13  18 eryefkrGCLvGnLgqEvaalpesfrerleevledw...qkrvaacleeaqeageiaadadaeelaef 82 
                 +  +++  CLv nL +E+++  e  +e l++++e+    ++++ +c+ + ++++  ++++ ++ +a+f
  EFC36554.1  48 HTLQYNGACLVLNLVEELKNNLEISEEILRNAIEKSkipKDKILRCIIKTRSNQPSDEQEWTNDFAHF 115
                 55799****************99999999999998622358999999999999888888777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       586  (0.0326845); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.48
# Mc/sec: 1402.35
//
Query:       EFC36555.1  [L=391]
Description: mevalonate decarboxylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.3e-69  232.4   1.2    5.1e-69  231.8   1.2    1.3  1  MDD_C           Mevalonate 5-diphosphate decarboxylase C-term
    5.1e-07   29.8   2.2    1.2e-06   28.7   1.4    2.0  2  GHMP_kinases_N  GHMP kinases N terminal domain


Domain annotation for each model (and alignments):
>> MDD_C  Mevalonate 5-diphosphate decarboxylase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  231.8   1.2   5.7e-73   5.1e-69       1     187 []     193     388 ..     193     388 .. 0.91

  Alignments for each domain:
  == domain 1  score: 231.8 bits;  conditional E-value: 5.7e-73
       MDD_C   1 vlilvvsdekkkvsStsGmqrsvetSeLlkhrakevvperieelekAikekdFetfaeitmkdSnqlhavcldtyPpifYlndtSraiielvhelNeaa 99 
                 ++++vvsd++k+++StsGmq+sv tS+Llk ra+e+vp+r+ e++kA+k+kdF+ fa++tm+dS+++ha+c+dt P+i+Y+n+tS++i++lv+++N++ 
  EFC36555.1 193 IVVCVVSDRQKHTPSTSGMQQSVITSKLLKVRASEIVPQRMIEMDKALKTKDFNLFATLTMDDSDNMHACCADTEPAIYYMNETSNQIVQLVKDFNAFD 291
                 69**********************************************************************************************866 PP

       MDD_C 100 .....gkikvAYtFDAGpNavlyleekdv.eellsllkklfppesdaeefvkgak.veea...aelseelkaslalkeskgavkriiltkvgdGpkvl 187
                      +++kvAYtFDAGpNavl++ +k+v +++l++l+++fpp s++e+f++++  v+e+   +e+ e++k+s+++k +++ ++++i+t+vg Gpkv+
  EFC36555.1 292 dgngvENLKVAYTFDAGPNAVLFFPNKEVtNKFLAILHAFFPP-SNQEQFFSKEPfVTEMkqyTEMVESFKKSTSVKIDADGLRYLIHTTVGYGPKVV 388
                 55555899*****************999846799999999999.566666666664444455578888999999*********************986 PP

>> GHMP_kinases_N  GHMP kinases N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   1.4   1.3e-10   1.2e-06       1      65 [.     107     161 ..     107     162 .. 0.74
   2 ?   -1.9   0.0      0.44     4e+03      42      62 ..     196     216 ..     177     218 .. 0.79

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 1.3e-10
                     EEEEEESSHTTSSSCHHHHHHHHHHHHHHHHTTEHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHS CS
  GHMP_kinases_N   1 divikseiPvgaGLGSSAAlavalvaAllallglsleeaklaleaerlaqggngsggDvaasvyG 65 
                     +i +++++P++aGL+SSA+  ++lv Al +l+++         ++   +  ++ + g ++ s+yG
      EFC36555.1 107 HIDSTNNFPTAAGLASSASGYCCLVFALGQLFEV---------KSDLSII-ARLGSGSACRSLYG 161
                     68899***************************53.........3333333.44455555555555 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.44
                     HHHHHHHHHHHHHHSHHHHHH CS
  GHMP_kinases_N  42 aleaerlaqggngsggDvaas 62 
                     ++++ r+ ++ ++sg+ ++++
      EFC36555.1 196 CVVSDRQKHTPSTSGMQQSVI 216
                     677888889999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       787  (0.0438954); expected 358.6 (0.02)
Passed bias filter:                      525  (0.0292822); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 2506.57
//
Query:       EFC36556.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 1407.28
//
Query:       EFC36557.1  [L=138]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-09   38.3   0.8    2.5e-09   37.4   0.8    1.5  1  MCM_lid   MCM AAA-lid domain


Domain annotation for each model (and alignments):
>> MCM_lid  MCM AAA-lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.4   0.8   1.4e-13   2.5e-09      33      86 ..       1      58 [.       1      59 [. 0.84

  Alignments for each domain:
  == domain 1  score: 37.4 bits;  conditional E-value: 1.4e-13
                HHHHH..TSS...TSSSST--HHHHHHHHHHHHHHHHHHTSSSE-HHHHHHHHHHHHHH CS
     MCM_lid 33 lRkee..eds...krksipitvRqLesliRLseAlAklrlsevvteedveeairllkes 86
                +R+++  + s   ++ ++++t+R++ s+ RL+e+ A+lr+s+ ++ +dv+ea rl+ es
  EFC36557.1  1 MRQNDerN-SkvsDKIQMYTTPRTILSIYRLAESKARLRFSSKIEISDVNEAERLILES 58
                56666431.1334677899************************************9886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (138 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       338  (0.0188521); expected 358.6 (0.02)
Passed bias filter:                      248  (0.0138323); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.32s 00:00:00.82 Elapsed: 00:00:00.51
# Mc/sec: 809.44
//
Query:       EFC36558.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-97  325.1   0.0      2e-97  324.7   0.0    1.1  1  MCM              MCM P-loop domain
    6.4e-20   71.3   3.8    1.1e-19   70.5   3.8    1.4  1  MCM_OB           MCM OB domain
    2.6e-09   36.8   0.1    2.2e-06   27.2   0.0    2.4  2  Mg_chelatase     Magnesium chelatase, subunit ChlI
    3.3e-06   27.1   0.0    1.4e-05   25.1   0.0    2.0  1  AAA_5            AAA domain (dynein-related subfamily)
    0.00078   19.3   0.0     0.0032   17.3   0.0    2.0  1  AAA_3            ATPase family associated with various cellul
     0.0071   16.1   0.0       0.32   10.7   0.0    2.3  2  Sigma54_activat  Sigma-54 interaction domain
     0.0087   16.5   0.0      0.029   14.7   0.0    1.8  1  AAA_16           AAA ATPase domain


Domain annotation for each model (and alignments):
>> MCM  MCM P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  324.7   0.0  7.8e-101     2e-97       5     223 ..     159     375 ..     156     376 .. 0.96

  Alignments for each domain:
  == domain 1  score: 324.7 bits;  conditional E-value: 7.8e-101
                 HHHHHTSSTHHHHHHHHSSTTSSS-HHHHHHHHHHHH---EBBBSSSSBBCSS-EEEEEESSTSTHHHHHHHHHHHSSSEEEEESSSSSSSHSSSEEEE CS
         MCM   5 ikelakekdiieklvksiapsiyghedvkkaillqlfggvkkkledktklrgdinvllvgdpgtaKsqlLkyveklapravytsgkgssaagLtaavvr 103
                 i+++ ++ + ++kl+ksiap+iygh +vkka+ll+l+g+++++++   k+rgd nv+l+gdpg+aKsqlL+++++++pr++yt+gkgss++gLtaav +
  EFC36558.1 159 IRKMGHD-QWYDKLSKSIAPEIYGHANVKKALLLMLIGAQTRETRG-LKIRGDLNVILMGDPGVAKSQLLRFISHISPRGIYTTGKGSSGVGLTAAVIK 255
                 6666665.79*******************************87755.**************************************************** PP

                 ESSSSSEEEEETHHHHTTTSEEEEESGGGSTCHHHHHHHHHHHHSEEEEESSSCEEEEE--EEEEEEE--SSSSCCTTS-HHHHSSSSHHHHHHSSEEE CS
         MCM 104 deetgefvleaGalvladkGvcciDefdkmkeedrsalhEamEqqtisiaKaGivatLnartsvlaAanpkagrydkkksvaeninlsaalLsrFDlif 202
                 d+ t+e++le+Galvlad+G+cciDefdkm+e dr+alhE+mEqq++siaKaGi++tLnart vlaAanp++gr+++++sv+eninl++al+srFDl+f
  EFC36558.1 256 DPLTNELILEGGALVLADNGICCIDEFDKMEEYDRTALHEVMEQQSVSIAKAGITTTLNARTCVLAAANPAYGRWNTRRSVSENINLPPALMSRFDLMF 354
                 *************************************************************************************************** PP

                 EE-SSTTHHHHHHHHHHHHHH CS
         MCM 203 vllDkvdeekDeelaehivsl 223
                 +llDk+++e D +la+hi+ +
  EFC36558.1 355 LLLDKQNNELDMNLARHITFV 375
                 *****************9865 PP

>> MCM_OB  MCM OB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.5   3.8   4.3e-23   1.1e-19      31     124 ..       2      98 ..       1     100 [. 0.90

  Alignments for each domain:
  == domain 1  score: 70.5 bits;  conditional E-value: 4.3e-23
                 EEEEEEETTT-.-EEES---....-S.B-..TTT-HHH-EEE-GGGSEEEEEEEEEEE-------------EEEEEEEGGGTT---TT-EEEEEEEEEE CS
      MCM_OB  31 kkavfeckkcgktvevelee....Pr.kCeekeCeskdpfkletekskfvdfqklklQEspeevpaGelPrslevileddlvdkvkPGdrvevtGiyra 124
                 k a+++c++c+ ++  ++++    P  +C +keC+  +++  +t++s fv+fq+l +QE+++evp+G++Pr++ v+++++l+++++PGd +++ Gi+  
  EFC36558.1   2 KVATYKCDTCSGMIYQTINQtsfiPIeTCVQKECK--GNLLQQTRESCFVKFQQLVIQEMSDEVPTGHIPRTMRVVMRGELTRTCTPGDSITCFGIFLP 98 
                 7899*******98876666677887558******9..78888999***************************************************975 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0011       2.9      10      47 ..     199     234 ..     190     240 .. 0.79
   2 !   27.2   0.0   8.5e-10   2.2e-06      98     160 ..     265     327 ..     258     362 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0011
  Mg_chelatase  10 eakraleiaaaGgHnlllvGppGsGKtmlakrlpsllp 47 
                   +  r l+  + G  n++l+G pG  K+ l + ++ + p
    EFC36558.1 199 RETRGLK--IRGDLNVILMGDPGVAKSQLLRFISHISP 234
                   4444444..47999***************999998877 PP

  == domain 2  score: 27.2 bits;  conditional E-value: 8.5e-10
  Mg_chelatase  98 kpGeislahnGvLfLDElpefkrkvlevLRePledgevtisrakakvefparfqlvaamNpcp 160
                   + G++ la nG+  +DE+ ++++    +L e +e+++v+i++a  +++  ar+ ++aa+Np+ 
    EFC36558.1 265 EGGALVLADNGICCIDEFDKMEEYDRTALHEVMEQQSVSIAKAGITTTLNARTCVLAAANPAY 327
                   67999********************************************************85 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.0   5.4e-09   1.4e-05       1     138 []     211     350 ..     211     350 .. 0.81

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 5.4e-09
                 EEEEE--SSSSHHHHHHHGGGGB.S--EEEEE--TT..--HHHHH--B--.........--------G-SEEEEESGGG--HHHHHHHHHHHHSSEEE. CS
       AAA_5   1 dvlLvGppGtgKselaerlaaal.nreveyvqltrd..tteedlkgrreikngttslvdsplvraaregeilvlDEveraesevlnsLlslleerrlll 96 
                 +v+L G+pG++Ks+l + +++   +  +++  ++++  +t++ +k ++     +  l+ ++lv       i+++DE++++e     +L+ ++e++ +++
  EFC36558.1 211 NVILMGDPGVAKSQLLRFISHISpRGIYTTGKGSSGvgLTAAVIKDPLT---NELILEGGALV--LADNGICCIDEFDKMEEYDRTALHEVMEQQSVSI 304
                 69*********************76666666676642267777777777...68889999999..77889****************************9 PP

                 .-SSSEEE---......-EEEEEESS--..........-TT-TTHHHHTT- CS
       AAA_5  97 eeggelvkaknddllerfrviatanpld.........rslnelspalrsRf 138
                 ++ g  +  ++      + v+a+anp++          +  +l pal sRf
  EFC36558.1 305 AKAGITTTLNAR-----TCVLAAANPAYgrwntrrsvSENINLPPALMSRF 350
                 999999988885.....89*******9977766644333345667777776 PP

>> AAA_3  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   1.2e-06    0.0032       2     113 ..     212     326 ..     211     351 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.2e-06
       AAA_3   2 vllegvPGlaktllvkalakaldlefkriqftpdl.lPsdilGtevfeekekefefkkGpvf...anllladeinrappktqsalleameerqvtve.. 94 
                 v+l g PG+ak +l + ++++     + i  t        ++ + + +  ++e+ ++ G+++   + +   de ++ +   ++al e+me++ v+++  
  EFC36558.1 212 VILMGDPGVAKSQLLRFISHIS---PRGIYTTGKGsSGVGLTAAVIKDPLTNELILEGGALVladNGICCIDEFDKMEEYDRTALHEVMEQQSVSIAka 307
                 6788889999998888887654...3445444433033456777777788899999999866332348999**********************999722 PP

       AAA_3  95 gethklpepflvlatqnPi 113
                 g t++l+   +vla+ nP 
  EFC36558.1 308 GITTTLNARTCVLAAANPA 326
                 56999*************6 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.031        80      19      48 ..     206     235 ..     195     241 .. 0.82
   2 !   10.7   0.0   0.00013      0.32      87     143 ..     267     325 ..     260     340 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.031
                      CTSSS-EEEECSTTSSHHHHHHHHHHHSTT CS
  Sigma54_activat  19 aktdlsvlitGesGtGKellaraiheaskr 48 
                      ++ dl+v+++G+ G+ K+ l r i + s+r
       EFC36558.1 206 IRGDLNVILMGDPGVAKSQLLRFISHISPR 235
                      56789**************99999877765 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00013
                      HHHHHTTTSEEEEETGGGS-HHHHHHHHHHHHHSE..EESBTSSSEEE--EEEEEEESS CS
  Sigma54_activat  87 GlfekadgGtlfLDeigelplelQekLlrvlqege..vervGsskeikvdvriiaatne 143
                      G++  ad+G+  +De  +++    + L +v+++++  + + G +++ ++ + ++aa+n 
       EFC36558.1 267 GALVLADNGICCIDEFDKMEEYDRTALHEVMEQQSvsIAKAGITTTLNARTCVLAAANP 325
                      8999***************************9997225799999999999999999885 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   1.1e-05     0.029      25     106 ..     210     298 ..     198     325 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.1e-05
      AAA_16  25 elvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysalaqalareellrqllde...............aesaeleawrekleeala 106
                  +v+l G++Gv Ks l+r +  +++ + gi+++gk  +       + l+ a  ++ l ++l  e               + ++  e++r++l+e+++
  EFC36558.1 210 LNVILMGDPGVAKSQLLRFIS-HISPR-GIYTTGKGSSG------VGLTAAVIKDPLTNELILEggalvladngiccidEFDKMEEYDRTALHEVME 298
                 799**************9999.89999.88888888887......5544444466777777777555555555555555555555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       833  (0.046461); expected 358.6 (0.02)
Passed bias filter:                      531  (0.0296168); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2430.27
//
Query:       EFC36559.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.018   15.6   4.6      0.026   15.1   4.6    1.3  1  MCM_N     MCM N-terminal domain
      0.039   14.0   0.2       0.64   10.1   0.0    2.2  2  Rab_bind  Rab binding domain


Domain annotation for each model (and alignments):
>> MCM_N  MCM N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   4.6   2.9e-06     0.026       1      86 [.      52     148 ..      52     152 .] 0.75

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.9e-06
       MCM_N   1 qekFedFLeefk.....ddsededge.......kkYrdqlqemaer......ekttLevdlddLaaf.deeLaeailenpkeylplleealkevvkkle 80 
                 +e +++FL ef+     +               + Y + + +++        ek  + +++ddL+    ++L  +i+en  +y +l+e+++++++ +le
  EFC36559.1  52 KETIKKFLLEFTsvqfnE-------LlqesemiFPYKKLIDQLKLHqleysdEKIKFPIQFDDLQIGgFKDLMFKIQENGMRYKKLFENVIDQLI-QLE 142
                 6889*******8776652.......0223345677777777766553445657789********988789************************9.555 PP

       MCM_N  81 psykdd 86 
                 +++ dd
  EFC36559.1 143 NDEFDD 148
                 555554 PP

>> Rab_bind  Rab binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   7.1e-05      0.64      20      45 ..      36      61 ..      28      66 .. 0.89
   2 ?    1.7   0.1     0.029   2.6e+02      29      49 ..      67      89 ..      63      94 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 7.1e-05
    Rab_bind 20 stttksvdhlngLLreteatnavLme 45
                + ttks  h+ + +re e     L+e
  EFC36559.1 36 NNTTKSSIHMPDYIREKETIKKFLLE 61
                789***************99999988 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.029
    Rab_bind 29 lngLLreteatn..avLmeqikL 49
                +n+LL+e+e       L++q+kL
  EFC36559.1 67 FNELLQESEMIFpyKKLIDQLKL 89
                79******975311346666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 977.94
//
Query:       EFC36560.1  [L=441]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-21   77.5   2.2    7.7e-21   75.0   0.1    2.1  2  Peptidase_S10  Serine carboxypeptidase
    6.5e-05   23.2  11.7    0.00017   21.9  11.7    1.8  1  EGF_2          EGF-like domain
     0.0048   17.2   9.1     0.0097   16.2   9.1    1.5  1  EGF            EGF-like domain
     0.0099   16.5   2.1      0.025   15.2   2.1    1.8  1  hEGF           Human growth factor-like EGF
  ------ inclusion threshold ------
      0.045   13.8   5.6      0.096   12.8   5.6    1.6  1  EGF_Tenascin   Tenascin EGF domain
      0.084   13.3   5.9       0.22   11.9   5.9    1.7  1  EGF_alliinase  Alliinase EGF-like domain


Domain annotation for each model (and alignments):
>> Peptidase_S10  Serine carboxypeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.0   0.1   2.6e-24   7.7e-21     277     417 ..      39     198 ..       8     200 .. 0.94
   2 ?    3.3   0.2     0.015        43     195     330 ..     199     391 ..     197     400 .. 0.65

  Alignments for each domain:
  == domain 1  score: 75.0 bits;  conditional E-value: 2.6e-24
                    HHHHHHHTSHHHHHHTT--..TTSSS--SB-HHHHHHCTCCC-SBCHHHHHHHHHTT-EEEEEEETT-STT-HHHHHHHHHHTECTTECCSCCCEE CS
  Peptidase_S10 277 syvekylnkkeVrkalhvn..asvkkweecndsvfeqleddisksveeileellesglrvliynGdvDlicnvlgteawikklelsgkkefrpwev 370
                    s++e+yln ++V++ l  n  + ++ +++c++++ +  ++d + ++ ++l  ll++ +r+li+nG+ D+ c v gt++ ++ +++ gk++f+   +
     EFC36560.1  39 SKLESYLNMESVKNVLLGNlnKDDYLYTQCSSKLWNDFKNDFQVDYVNYLIPLLSK-YRILIINGQFDIRCSVYGTNEYLRLMNWYGKQDFNYEPH 133
                    6899************766669999*********888899999999999999**99.*************************************99 PP

                    EE..................TTTCESEEEEEEEETTEEEEEETT--SSHHHHSHHHHHHHHHHHH CS
  Peptidase_S10 371 sp..................kkengqvaGyvkeyenltfltvkgaGHmvPedkpeealqllerfi 417
                    +p                  +++n+ + G +k+yenl  +  + +GH  P d p +++++++rf+
     EFC36560.1 134 YPfysssisnnnnnningntNNNNNIILGIFKKYENLRQVILYSSGHLSPHDVPYASFEMISRFL 198
                    999***************988899999************************************98 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.015
                    HHTTSSHHHHHHHHHHHHEET...HHHHHHHHHHHHHHHHHHHHH....................HHHHCHCEETTETTSEETTSSEE........ CS
  Peptidase_S10 195 yehgliseeeyeslkkacekk...eeleqesekcanllekaskva....................vekenkglnvynileeccklkae........ 259
                    y++++ + +++es ++++e +    +++ ++ kc n+ ++  k+                     +                     +        
     EFC36560.1 199 YKKSFCNYTNMESETSTIECNdfkIDYQTNTMKCPNQCSNHGKCLinskcecelgyygndcsiirN---------------------Ditfgkqai 273
                    555555555555444443333444888888889999999888887444444344333333333330.....................122333344 PP

                    ...............................................HHHCTTCCCCTTTTTCHHHHHHHHTSHHHH.HHTT--TTSSS--SB-HH CS
  Peptidase_S10 260 ...............................................lkksstdaqggedpydesyvekylnkkeVr.kalhvnasvkkweecnds 307
                                                                   +++ +  + +++   + +++ +y++ ++V  k l+++ + ++ +  + +
     EFC36560.1 274 ynnnlifgnnyhlynllipfdnsiglfdirliltktsklgklhlylqPNNETFLNITNNFNDNFKNIFNYYDLEDVNeKTLQIS-NLNRNSTHSLT 368
                    555555555566666666666778888888999999999999999887777788889999999999999999999972568885.55555555556 PP

                    HHHHCTCCC-SBCHHHHHHHHHT CS
  Peptidase_S10 308 vfeqleddisksveeileelles 330
                    +   ++ d++++++ i+e+++++
     EFC36560.1 369 IIVLNTVDTESNYNLIVETIVSG 391
                    65777788888888888888776 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9  11.7   5.6e-08   0.00017       1      32 []     232     259 ..     232     259 .. 0.91

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 5.6e-08
       EGF_2   1 CsasdeiCgghGtC.vnqcGqCdCdsgyqGktC 32 
                 C++    C++hG+C +  + +C+C+ gy+G++C
  EFC36560.1 232 CPNQ---CSNHGKClI--NSKCECELGYYGNDC 259
                 8865...*******77..789************ PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   9.1   3.2e-06    0.0097       1      31 [.     232     257 ..     232     258 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 3.2e-06
                 GCSTTSTTT-EE.EEETTTEEEEEECTTEEST CS
         EGF   1 CspnpCsngGtC.vdtgrggytCiCpeGytGk 31 
                 C+ n Csn+G+C ++++     C+C  Gy G+
  EFC36560.1 232 CP-NQCSNHGKClINSK-----CECELGYYGN 257
                 66.99*******88888.....********97 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   2.1   8.4e-06     0.025       1      22 []     236     254 ..     236     254 .. 0.98

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 8.4e-06
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+n+G C   +++ kC+C  Gy
  EFC36560.1 236 CSNHGKCL--INS-KCECELGY 254
                 ********..***.*****999 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   5.6   3.2e-05     0.096       2      29 .]     232     260 ..     231     260 .. 0.95

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.2e-05
  EGF_Tenascin   2 CPLGCssRGvC.vDGqCiCDsEYsGDDCs 29 
                   CP  Cs  G C ++ +C C+  Y G+DCs
    EFC36560.1 232 CPNQCSNHGKClINSKCECELGYYGNDCS 260
                   ***********6699*************9 PP

>> EGF_alliinase  Alliinase EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   5.9   7.4e-05      0.22      17      54 ..     235     265 ..     231     266 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 7.4e-05
  EGF_alliinase  17 sCSGhGraflDglvldgkpvCECnsCyaGkdCsqllpd 54 
                    +CS hG+  +       ++ CEC+  y G+dCs + +d
     EFC36560.1 235 QCSNHGKCLI-------NSKCECELGYYGNDCSIIRND 265
                    6888998887.......789*************87665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1037  (0.0578393); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.63u 0.29s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 2763.92
//
Query:       EFC36561.1  [L=266]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00025   21.4   6.5    0.00046   20.5   6.5    1.6  1  MBR1          Mitochondrial biogenesis regulation protein 1


Domain annotation for each model (and alignments):
>> MBR1  Mitochondrial biogenesis regulation protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   6.5   2.6e-08   0.00046      41     120 ..      58     144 ..       9     167 .. 0.67

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 2.6e-08
        MBR1  41 lkeillslsevkieeesengnvgevnslssndpldektsrrqnlrkikTapya..........pnsiseestssntqilrkkekrsesee 120
                   ++ + +++ ++ ++s+n+n ++++s ss +  + + +++q++rk+ T+py+          +   ++ +t+sn++++++ +++s++++
  EFC36561.1  58 NRKS-ITFNSIPSLQSSNNNNNNNLSS-SSITSSNVNNQQQQQIRKVLTSPYFgerphyflppSDVEQYRKTISNNSNNSN-NSNSNNNN 144
                 2222.4455555555566666665555.7788899999999************9999999887444444555555555555.22222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2104  (0.117352); expected 358.6 (0.02)
Passed bias filter:                      672  (0.0374812); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 1789.71
//
Query:       EFC36562.1  [L=147]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.8e-06   26.9  87.9      0.027   14.4  43.0    3.0  3  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1  37.0   1.9e-06     0.034      59     112 ..       4      57 ..       1      63 [. 0.59
   2 !   12.8  29.6   4.7e-06     0.085      59     111 ..      38      91 ..      37      95 .. 0.44
   3 !   14.4  43.0   1.5e-06     0.027      52     111 ..      66     125 ..      59     142 .. 0.46

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.9e-06
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepepg 112
                  p+p+p+p+p+ +p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p 
   EFC36562.1   4 PKPKPKPKPKSKPKPKPKPKPKPKPKPKPKPKPKPKPKPNPNPNPNPNPNPNPT 57 
                  455555555555566666666666666666666666666666666666666665 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 4.7e-06
  Trypan_PARP  59 pepepepepepepepepepep.etepeeepepepepepepepepepepepepep 111
                  p+p+p+p+p+p+p+p+p+p + +t+ + +++ +++p+p+p+p+p+p+p+p+p+p
   EFC36562.1  38 PKPKPNPNPNPNPNPNPNPTQtQTQTQTQTQTQTQPKPKPKPKPKPKPKPKPKP 91 
                  455566666666666666655533333444444444444444444444444433 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 1.5e-06
  Trypan_PARP  52 ddtngtdpepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  +    t+p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC36562.1  66 QTQTQTQPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 125
                  333444555555555555444444444444444433333333333333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (147 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       693  (0.0386525); expected 358.6 (0.02)
Passed bias filter:                      225  (0.0125495); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                        52  (0.00290033); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.05u 0.36s 00:00:01.41 Elapsed: 00:00:00.57
# Mc/sec: 775.95
//
Query:       EFC36563.1  [L=553]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0031   17.2   4.8        0.2   11.5   0.1    4.6  4  LRR_8          Leucine rich repeat
  ------ inclusion threshold ------
       0.15   11.3   2.6       0.99    8.6   0.0    2.8  4  Herpes_UL37_2  Betaherpesvirus immediate-early glycoprotein U
        0.3   11.6   0.1        0.3   11.6   0.1    6.2  6  LRR_4          Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   0.1   3.3e-05       0.2      25      60 ..     279     316 ..     273     317 .. 0.82
   2 ?   -2.5   0.1      0.77   4.6e+03      27      41 ..     410     424 ..     408     431 .. 0.65
   3 ?    3.0   0.1     0.014        84      24      53 ..     492     521 ..     487     523 .. 0.84
   4 ?    2.2   0.0     0.026   1.6e+02      35      50 ..     517     532 ..     515     535 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 3.3e-05
                 TT--EEE--SS.---G.GGGGGGTT--S-.EEE--SS- CS
       LRR_8  25 snLkvLdLsnN.lltt.lspgafsgLpsLrsLdLsgNr 60 
                 ++Lk ++L+ N +++     ++f +Lp+L++  +++N 
  EFC36563.1 279 KKLKKIKLKGNsNISDdSLYKVFKNLPHLTHFEIENNA 316
                 78999999999999886446899999999999999985 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.77
                 --EEE--SS---GGG CS
       LRR_8  27 LkvLdLsnNllttls 41 
                 Lk+L+L  N+l+++ 
  EFC36563.1 410 LKTLELFVNTLESFT 424
                 777777777777664 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.014
                 -TT--EEE--SS---GGGGGGGTT--S-.E CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrs 53 
                 ++nLk+L+ ++N  ++ + ++ + L+ L+ 
  EFC36563.1 492 FPNLKILKFKENVSSSYDTQTADVLNVLKV 521
                 69**********999999998888887765 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.026
                 S---GGGGGGGTT--S CS
       LRR_8  35 NllttlspgafsgLps 50 
                 N l++++ g f++L+ 
  EFC36563.1 517 NVLKVINDGHFQHLEM 532
                 7888888888888865 PP

>> Herpes_UL37_2  Betaherpesvirus immediate-early glycoprotein UL37
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.0   0.00017      0.99     147     221 ..      24      99 ..       2     122 .. 0.70
   2 ?   -3.3   0.0      0.67     4e+03     217     234 ..     148     165 ..     142     207 .. 0.63
   3 ?    1.5   0.1     0.024   1.4e+02     169     202 ..     270     301 ..     256     319 .. 0.66
   4 ?   -2.7   0.0      0.44   2.6e+03     147     170 ..     503     527 ..     473     534 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00017
  Herpes_UL37_2 147 natssenntvtvlsv.ltvrveldiiflsdicPrllkkkvklikndrknkkflrttvrslpewtlqqcqawkywtk 221
                    n+ + +  t   +s+ l+   + +i+ l  +c +l+    +l+    ++++f  +++ s    ++    +w    k
     EFC36563.1  24 NSLTIHHLTQDEMSIvLNFLHKGEILILATLCKQLYSTIYNLVESIIHPREFNVENWSSRSLESMLSHYSWLDVGK 99 
                    444455556666775277778899**********************************955445555555554444 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.67
  Herpes_UL37_2 217 kywtklsimykeikeall 234
                    ++w kls  y++ ++ + 
     EFC36563.1 148 QQWIKLSNKYQDTRNTVE 165
                    579999999999888763 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.024
  Herpes_UL37_2 169 diiflsdicPrllkkkvklikndrknkkflrttv 202
                     i+f+s++c +l k k  l  n + +   l + +
     EFC36563.1 270 LIVFISEMCKKLKKIK--LKGNSNISDDSLYKVF 301
                    589********96554..4444444444444444 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 0.44
  Herpes_UL37_2 147 nat.ssenntvtvlsvltvrveldi 170
                    n + s + +t  vl+vl+v  +  +
     EFC36563.1 503 NVSsSYDTQTADVLNVLKVINDGHF 527
                    4330345678889999988766555 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   1.8     0.089   5.3e+02       4      30 ..     179     202 ..     177     236 .. 0.72
   2 ?   -3.6   0.1         3   1.8e+04      22      28 ..     251     257 ..     244     258 .. 0.62
   3 ?   11.6   0.1     5e-05       0.3       1      33 [.     279     315 ..     274     332 .. 0.80
   4 ?    1.2   0.0     0.095   5.7e+02      21      32 ..     356     367 ..     347     377 .. 0.77
   5 ?    0.4   0.1      0.17     1e+03       3      17 ..     410     424 ..     409     463 .. 0.65
   6 ?    0.8   0.4      0.13   7.5e+02      16      30 ..     482     500 ..     461     507 .. 0.68

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.089
                 -EEE--.SS---E-S-HHH-TT--EEE- CS
       LRR_4   4 evLdLs.nNqltdiplleklpnLkeLdL 30 
                 ++L+L  nN  ++++    l n +eL L
  EFC36563.1 179 RKLCLVsNNPFKTLNY---LQNIEEL-L 202
                 6777776778888777...7777776.4 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 3
                 -TT--EE CS
       LRR_4  22 lpnLkeL 28 
                  pnL+ L
  EFC36563.1 251 SPNLERL 257
                 5777766 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 5e-05
                 SS--EEE--SS.---E-S-...HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnN.qltdipl...leklpnLkeLdLsgN 33 
                 ++L+++ L +N +++d +l   +++lp+L+++ + +N
  EFC36563.1 279 KKLKKIKLKGNsNISDDSLykvFKNLPHLTHFEIENN 315
                 68*******8889**8666666668*********666 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.095
                 H.-TT--EEE-.- CS
       LRR_4  21 k.lpnLkeLdLsg 32 
                 + lpnL+ L L g
  EFC36563.1 356 GiLPNLEFLEL-G 367
                 55999999998.4 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.17
                 --EEE--SS---E-S CS
       LRR_4   3 LevLdLsnNqltdip 17 
                 L++L L+ N l ++ 
  EFC36563.1 410 LKTLELFVNTLESFT 424
                 555555544444433 PP

  == domain 6  score: 0.8 bits;  conditional E-value: 0.13
                 -S-...HHH.-TT--EEE- CS
       LRR_4  16 ipl...lek.lpnLkeLdL 30 
                 ++    l+k +pnLk L  
  EFC36563.1 482 LEYllkLSKvFPNLKILKF 500
                 4444334477999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (553 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       596  (0.0332422); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.44
# Mc/sec: 3797.41
//
Query:       EFC36564.1  [L=177]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-07   31.4   4.0    1.6e-07   31.4   4.0    2.2  2  Zn_clus          Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
       0.72    9.9   6.4        1.1    9.3   6.4    1.5  1  Mitochondr_Som1  Mitochondrial export protein Som1


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   4.0   1.7e-11   1.6e-07       2      39 ..      75     111 ..      74     113 .. 0.91
   2 ?   -0.6   0.2      0.17   1.5e+03      28      32 ..     116     120 ..     112     127 .. 0.54

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 1.7e-11
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 +C n r+ + KCd+k P Cs+C+ ++leC  y e++++
  EFC36564.1  75 SCLNWRRVHKKCDKKLPFCSRCVIHGLECI-YVEPRRK 111
                 89999*************************.7776665 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.17
                 HHHCC CS
     Zn_clus  28 leCtf 32 
                 ++C +
  EFC36564.1 116 KKCDK 120
                 55552 PP

>> Mitochondr_Som1  Mitochondrial export protein Som1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   6.4   0.00012       1.1      15      75 ..      23      88 ..       7     145 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00012
  Mitochondr_Som1 15 ervqvkeklekkrkeeeve..LkkCeLkelvQyeCtfkeskkeekekk...iiClpvkRlfrrCke 75
                      +++++++++++  e+  +  ++ C+ k+l   +  ++e+k++++ ++   i Cl  +R+ ++C++
       EFC36564.1 23 GHTNQQQQQPNNTTENIFKrpITACSTKHLQITNNIISEEKTSSEDENvhsISCLNWRRVHKKCDK 88
                     455555555444444433366999*99998666665655554433333678*************43 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       960  (0.0535445); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1155.74
//
Query:       EFC36565.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       472  (0.0263261); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 1017.73
//
Query:       EFC36566.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-27   97.1  34.4    1.4e-27   96.8  34.4    1.0  1  TPT       Triose-phosphate Transporter family
    9.1e-05   22.6  40.2     0.0012   19.1   7.5    2.9  3  EamA      EamA-like transporter family
  ------ inclusion threshold ------
       0.15   12.2   5.4      0.052   13.6   1.0    2.5  2  DUF1003   Protein of unknown function (DUF1003)
       0.22   11.9   1.9        1.9    8.9   1.8    2.5  2  ATP19     ATP synthase subunit K
       0.57   10.7   9.6        1.4    9.5   0.0    3.5  3  DUF4231   Protein of unknown function (DUF4231)


Domain annotation for each model (and alignments):
>> TPT  Triose-phosphate Transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   96.8  34.4   3.9e-31   1.4e-27       5     290 .]      69     356 ..      66     356 .. 0.90

  Alignments for each domain:
  == domain 1  score: 96.8 bits;  conditional E-value: 3.9e-31
         TPT   5 llfllWYllnvvfnilnKkil.nvfpyPltvsavqllvgsvlilvlwalglkk....rpkisseflkailplalvktlghvlavvslskvaVSfthtvK 98 
                 l +++W+ ln++  + nK ++ + f +P+++s++++l+ ++l++++++ + ++      +i++e  k +    +v +l  v +++ + +++   +++v+
  EFC36566.1  69 LWVFTWFSLNITIAFGNKIVYwQGFSFPTILSLFHMLASWLLAFISLRYQNRNdasaEVEIKAEAKKHMWLYIVVFILNIVYGNIGIFRTSLHMSQIVR 167
                 67899***************84568*****************99998875555444477888889999******************************* PP

         TPT  99 asePiFtvilsrlllgeklsllvylsLlpivgGvalasvtElsFnligfisAlisnltfslrnifsKkllkklkdldalnlfaiitilslllllPvall 197
                 ++ P+F  +ls l++g ++s+ ++  +  +++Gv+++ v  l+ n++  i  +i nl+++l+ ++    lk++k ++ l l+++++  + l +l ++++
  EFC36566.1 168 STTPLFVMVLSYLIVGTTTSIHKLAIVSLVIAGVIMSIVNNLEINMTDVIILMIGNLFAALKTVLTNLSLKSHK-ISPLVLMNYVAPYASLGMLMITIV 265
                 ************************************************************************55.***********9999988888877 PP

         TPT 198 vegvlktpsllkstkvslkevllllllsgvlfhlynqvaymvLervspvthsvantvKrvvvIvlsvlvfkn.pvsllnaiGtavaivGvflYs 290
                   ++++++s +++   +l+ vl+ +l+s + f+l n++ + + +++sp+t s++  +K+v+v+v+s+ ++++  v+++n+iG ++++ G ++Ys
  EFC36566.1 266 NGELVRFMSEYHKV--TLYGVLAVILTSIMSFFL-NTTNFIANKMTSPLTMSLSANLKQVLVVVVSLCFLHQgGVTSVNIIGISMTLSGMLIYS 356
                 77766666655554..689999888888777776.7899****************************9998637*******************8 PP

>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   2.5     0.078   2.8e+02      56      91 ..      83     120 ..      56     129 .. 0.69
   2 !   19.1   7.5   3.2e-07    0.0012      70     136 ..     143     205 ..     126     206 .. 0.81
   3 !   13.9  14.4   1.3e-05     0.045       4     135 ..     216     355 ..     213     357 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.078
        EamA  56 l..aklslkdwllllllgllgtvlafllffyalkktsa 91 
                 +  +   ++++ +  +l+l+ +++ +ll f++l++ + 
  EFC36566.1  83 FgnKIVYWQGFSFPTILSLFHMLASWLLAFISLRYQNR 120
                 232235677788889*****************998765 PP

  == domain 2  score: 19.1 bits;  conditional E-value: 3.2e-07
        EamA  70 lgllgtvlafllffyalkktsasnaslitslePvftlilsvlllgekltlkqllgivlillGvllil 136
                 + +l++v      ++++ +ts     ++ s++P+f+++ls+l+ g + ++ +l+ + l+++Gv++ +
  EFC36566.1 143 VFILNIVY----GNIGIFRTSLHMSQIVRSTTPLFVMVLSYLIVGTTTSIHKLAIVSLVIAGVIMSI 205
                 22233333....4799999********************************************9976 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 1.3e-05
        EamA   4 illallaalfwaiyfvlskillrkv..spltltfvrfliagillliiallkegkl......aklslkdwllllllgllgtvlafllffyalkktsasna 94 
                 +++++++ lf a+ +vl+   l+++  spl l  +    a++ +l+i+ ++++         k +l ++l+++l+++++++l     f+a k ts+ + 
  EFC36566.1 216 VIILMIGNLFAALKTVLTNLSLKSHkiSPLVLMNYVAPYASLGMLMITIVNGELVrfmseyHKVTLYGVLAVILTSIMSFFLN-TTNFIANKMTSPLTM 313
                 67889999**********999666622777766676679***99999888888777787778888999********9999998.89************* PP

        EamA  95 slitslePvftlilsvlll.gekltlkqllgivlillGvlli 135
                 sl  +l  v++++ s  +l +  +t+  ++gi + l G l+ 
  EFC36566.1 314 SLSANLKQVLVVVVSLCFLhQGGVTSVNIIGISMTLSGMLIY 355
                 *******************5568***************9976 PP

>> DUF1003  Protein of unknown function (DUF1003)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   1.0   1.5e-05     0.052       9      72 ..      66     132 ..      61     150 .. 0.78
   2 ?   -0.9   0.2       0.5   1.8e+03      42      56 ..     234     248 ..     191     251 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.5e-05
     DUF1003   9 lftaivilWialnllvlp..glkpfDpypFillnlvlslqaa.laaplIllsqnRqadrdrvraeed 72 
                 +  ++v++W+ ln++++   ++  +  + F  +  ++ ++a+ l+a + l  qnR+++ ++v+ + +
  EFC36566.1  66 IGGLWVFTWFSLNITIAFgnKIVYWQGFSFPTILSLFHMLASwLLAFISLRYQNRNDASAEVEIKAE 132
                 55689*********98767778889999997666666666551555555778*******99987765 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.5
     DUF1003  42 vlslqaalaaplIll 56 
                  lsl +  ++pl+l+
  EFC36566.1 234 NLSLKSHKISPLVLM 248
                 357777777788887 PP

>> ATP19  ATP synthase subunit K
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.51   1.8e+03      17      53 ..      99     135 ..      96     145 .. 0.78
   2 ?    8.9   1.8   0.00053       1.9       1      31 [.     175     205 ..     175     209 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.51
                 SHHHHHHHHH--XXXXXXXXXXXX...XXXXXXXXXX CS
       ATP19  17 LAlgtLgttglivylamggskkkkaaaappinasssd 53 
                 L+l  + +  l+++++ + ++ + a+a+++i+a+ ++
  EFC36566.1  99 LSLFHMLASWLLAFISLRYQNRNDASAEVEIKAEAKK 135
                 6777777778888888888888888889999998765 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00053
                 XXXX---STTSS--S-SHHHHHHHHH--XXX CS
       ATP19   1 MgaaYtIaGravkshyLAlgtLgttglivyl 31 
                 M+ +Y I+G +   h LA+  L+ +g+i+++
  EFC36566.1 175 MVLSYLIVGTTTSIHKLAIVSLVIAGVIMSI 205
                 999********************99999875 PP

>> DUF4231  Protein of unknown function (DUF4231)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.1     0.065   2.3e+02      20      69 ..      99     162 ..      92     165 .. 0.76
   2 ?    2.0   1.7      0.08   2.9e+02      17      65 ..     189     233 ..     183     242 .. 0.63
   3 ?    9.5   0.0   0.00038       1.4      50      79 ..     279     308 ..     255     310 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.065
     DUF4231  20 lrlitivlgallpilvs..............sklgagvsvlkiltallsalvailaaleeffry 69 
                 l+l+ ++++ ll++++               + ++ + ++l i++++l+++   + ++ +  ++
  EFC36566.1  99 LSLFHMLASWLLAFISLryqnrndasaeveiKAEAKKHMWLYIVVFILNIVYGNIGIFRTSLHM 162
                 5666677777777777788888888888888778889999999999999987777777666665 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.08
     DUF4231  17 frllrlitivlgallpilvssklgagvsvlkiltallsalvailaalee 65 
                 ++ l+++++v++ ++  +v+   + + +++ +++++++ l a l  + +
  EFC36566.1 189 HK-LAIVSLVIAGVIMSIVN---NLEINMTDVIILMIGNLFAALKTVLT 233
                 44.66666666665555555...46777777777777766666666555 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00038
     DUF4231  50 tallsalvailaaleeffrykerWrryRst 79 
                 ++l ++l++il+++++ff    +++++++t
  EFC36566.1 279 VTLYGVLAVILTSIMSFFLNTTNFIANKMT 308
                 578899**********************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1115  (0.0621897); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 2187.60
//
Query:       EFC36567.1  [L=473]
Description: hypothetical protein NAEGRDRAFT_54263 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0022   17.8   0.1     0.0064   16.3   0.1    1.8  1  F-box     F-box domain
  ------ inclusion threshold ------
      0.067   12.8   0.0       0.18   11.4   0.0    1.7  2  DUF2659   Protein of unknown function (DUF2659)


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   7.1e-07    0.0064       6      43 ..      92     129 ..      89     134 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 7.1e-07
                 S-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHH CS
       F-box   6 LPsevlrhILerLplsdllalrrVSkgwrilidsdrlw 43 
                 LP e++r +L +++ ++l a+   +k +++++++d  +
  EFC36567.1  92 LPIELIRVVLDYCDQKELQAMLTSCKLLYNILRMDMYY 129
                 9*******************************998665 PP

>> DUF2659  Protein of unknown function (DUF2659)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0     2e-05      0.18      86     142 ..     235     291 ..     196     305 .. 0.88
   2 ?   -3.2   0.0      0.59   5.3e+03     103     123 ..     339     357 ..     334     363 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 2e-05
     DUF2659  86 yntkvqelahiqllahkikvgsftevkqlaneilamksysnftkayvrlnllamaid 142
                  n  v+ l +++ll +k kv +    + + n  +a++ y nf +++ rl+ll  a +
  EFC36567.1 235 LNLMVNTLFKLRLLVQKYKVSTAIPTRVVPNLRMALRDYRNFFHSHPRLKLLLSARE 291
                 6788999********************************************987754 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.59
     DUF2659 103 ikvgsftevkqlaneilamks 123
                  kvg ft vk  +ne+l ++s
  EFC36567.1 339 SKVGGFTCVK--CNELLLINS 357
                 599****999..588887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (473 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       731  (0.0407719); expected 358.6 (0.02)
Passed bias filter:                      318  (0.0177366); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 3046.17
//
Query:       EFC36568.1  [L=265]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00095   18.5   0.9      0.001   18.4   0.9    1.2  1  Zip       ZIP Zinc transporter


Domain annotation for each model (and alignments):
>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.9   5.7e-08     0.001      75     172 ..      30     135 ..       9     236 .. 0.64

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 5.7e-08
         Zip  75 h.....plagllvllGflllllveklltmivek.ksshkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesek 167
                 +     ++   l+ +G++l+ll+e +++ +v+k +s  +++++ + +s++  ++ ++  +n+++   +  ++++++++   +s+ +l++  +++++++ 
  EFC36568.1  30 FillsfMMSMYLLTVGYYLILLTEWFIHKLVAKrHSLYNNNNCVDDNSPTMIKNQQDDSNNNNSVIYTTTTNNESSQQQLINSECTLSETPENTNSNNN 128
                 145555777888999******************733344555555555555555444444444433333334444444444444444444444444444 PP

         Zip 168 eqas..e 172
                 ++++  +
  EFC36568.1 129 QHENdeS 135
                 4433220 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (265 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2097  (0.116961); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1659.81
//
Query:       EFC36569.1  [L=439]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
          1    7.8  28.9        1.4    7.3  28.9    1.1  1  Nucleoporin_FG2  Nucleoporin FG repeated region


Domain annotation for each model (and alignments):
>> Nucleoporin_FG2  Nucleoporin FG repeated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3  28.9   7.9e-05       1.4      63     228 ..      12     182 ..       7     232 .. 0.42

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 7.9e-05
  Nucleoporin_FG2  63 faqkpatGfslgtpasgaaaaaatgltlgapaataaastGfslafnk.paasatpfs...lttsstagaGlslgsvltstaqqagatgftlnlG 152
                      f++ +++ fs+g+++++a+++ +      ++++t+++s   s +f    + sat fs   l+t++t++    ++ +   t+ ++++t   l+  
       EFC36569.1  12 FGASETSSFSFGAATTAASTSNT----NTSSTTTTTTSQPVSSSFGTtTTPSATTFSfqpLPTTTTSNNTKPITGSCFGTTPNPTSTQPPLAST 101
                      56666666666665555444222....2222233333333444443303445666652223334444433333333333334444444444333 PP

  Nucleoporin_FG2 153 gatatstaastvlslgstlaglggslfsstaatglGqt..tlGaglg......atstapvaapaasiGlGGvdfstssekksdk 228
                      gat  s +a+ ++s   +  g+g+s f s +at+  ++  ++G  l+       tst  + +  +  G  G+d+     + sd 
       EFC36569.1 102 GATFGSFSATQAPS---STGGFGTSPFGSVQATTASNSnpSVGFNLNctstvfQTSTVNTGDYIPLSGPNGIDLIKKCTNFSDL 182
                      33333333333333...2223333333322222211110022222222222335555555555666666666666666665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (439 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       842  (0.046963); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 2750.77
//
Query:       EFC36570.1  [L=380]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-14   54.2   1.1    2.5e-14   53.4   0.3    1.7  2  BTB              BTB/POZ domain
     0.0045   16.4   0.7     0.0073   15.7   0.7    1.3  1  Fanconi_A_N      Fanconi anaemia group A protein N terminus
  ------ inclusion threshold ------
       0.39   10.7   3.0         80    3.3   0.0    3.8  4  Lep_receptor_Ig  Ig-like C2-type domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.4   0.3   4.2e-18   2.5e-14       3     107 ..     215     315 ..     212     317 .. 0.90
   2 ?   -2.9   0.0       1.3   7.7e+03      66      94 ..     342     369 ..     331     377 .. 0.54

  Alignments for each domain:
  == domain 1  score: 53.4 bits;  conditional E-value: 4.2e-18
                 HHHHHTTTS-EEEEETT.TEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHH CS
         BTB   3 elresgelcDvtlvvgd.gkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlk 100
                 ++++ + ++Dvt+ + + +k++ ahk + a+rSpy+ +++t +   +  + ++   dv++e++++ ++f+Y+ ++ ++  ++l el a+a+++++++lk
  EFC36570.1 215 AQEDGQNYSDVTISLVNsDKQINAHKGIIASRSPYLLKQLTVQ---DGPQIHLG-LDVSFESLKQAISFLYCNHCAVS-LDTLFELYAIANIFDCDDLK 308
                 5667779******99999*************************...44544454.79********************6.******************** PP

                 HHHHHHH CS
         BTB 101 kaceefl 107
                 + ce+ l
  EFC36570.1 309 EFCEHNL 315
                 ****987 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.3
                 HHHHHHHHSEEEC-CGGGHHHHHHHHHHH CS
         BTB  66 alLefiYtgeleitseenleelLaaadll 94 
                  +L++++    +i+ +  l+++L+  d l
  EFC36570.1 342 TILRVMFKHYDRIQ-QLGLQQILTEKDAL 369
                 45555555544443.45555555555555 PP

>> Fanconi_A_N  Fanconi anaemia group A protein N terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.7   1.2e-06    0.0073      96     165 ..     266     337 ..     262     374 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.2e-06
  Fanconi_A_N  96 lsslldalaaepqeeslaykevkl.svfsasllksslsddalkrffnhhLtqlLtlkpvlk.vsdAvqlqse 165
                  l   +++l++  +   +++ +v+l  +f+  ++ ++   d+lk+f++h Lt+lLt ++ ++  ++Avq+ + 
   EFC36570.1 266 LDVSFESLKQAISFLYCNHCAVSLdTLFELYAIANIFDCDDLKEFCEHNLTLLLTPSNLQEvYDKAVQNHHT 337
                  556788899999999999***999999*******************************99944679987664 PP

>> Lep_receptor_Ig  Ig-like C2-type domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.013        80       4      23 ..      67      86 ..      64     102 .. 0.82
   2 ?    2.7   0.1     0.021   1.2e+02      15      46 ..     117     147 ..     109     175 .. 0.71
   3 ?    2.3   0.0     0.027   1.6e+02      62      79 ..     267     284 ..     252     288 .. 0.87
   4 ?   -2.8   0.0       1.1   6.6e+03      50      71 ..     333     354 ..     325     357 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.013
  Lep_receptor_Ig  4 gvisvespvvslGsnvtasC 23
                     +vi +++   +lG+nvta C
       EFC36570.1 67 QVIGPPTCYPNLGDNVTAWC 86
                     56777777789********* PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.021
  Lep_receptor_Ig  15 lGsnvtasCilkenCshlsveakiivWklkne 46 
                       Gs+  +sC +++  ++ ++e  i++W  k+ 
       EFC36570.1 117 PGSTCKISCKVYK-GEEDKSEEWIVLWEDKTV 147
                      59999****9998.566677777777865544 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.027
  Lep_receptor_Ig  62 sVtlpnlnatkalLtCcl 79 
                       V++++l++  ++L+C++
       EFC36570.1 267 DVSFESLKQAISFLYCNH 284
                      699*************97 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 1.1
  Lep_receptor_Ig  50 geqytvlndtvssVtlpnlnat 71 
                      +++ t+l+dt+ +V +++  + 
       EFC36570.1 333 QNHHTSLTDTILRVMFKHYDRI 354
                      5677888888889988887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (380 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       612  (0.0341346); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2429.91
//
Query:       EFC36571.1  [L=138]
Description: cofilin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.3e-33  114.0   0.4    3.6e-33  113.9   0.4    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.9   0.4     2e-37   3.6e-33       4     120 ..      13     131 ..      10     132 .. 0.95

  Alignments for each domain:
  == domain 1  score: 113.9 bits;  conditional E-value: 2e-37
                  HHHHHCTTT.SSEEEEEEECTTTEEEEEESS-...HHHHHHHHHHTTT-EEEEEEEEEECCSECCEEEEEEEEE--TTS-HHHHHHHHHHHHHHHHHC CS
  Cofilin_ADF   4 afkelksgkktkyilfkidddkeeivveeege...tyeelreelpeseprYavydveyehddeskrsklvfIswvPdsapikqkmlyasskdalkkel 98 
                   f+ +k++k+ ++i f+++ + +++vv+e+ +   +y++++++lp++++ Yav+d++y+++d + r+k++fI+w P +apik+km+ya++k+++k++l
   EFC36571.1  13 DFNAMKLKKESQAIKFGMTAKLDQVVVVEKLAygtSYDDFINSLPDNDCLYAVVDFHYDNED-GHRQKMIFINWAPVKAPIKKKMVYAATKQSVKDKL 109
                  5999******************9999999666777**************************9.9********************************** PP

                  TTSEEEEEE-CGGCCSHHHHHH CS
  Cofilin_ADF  99 kgisveieatdldelteeelke 120
                   gis ei+atd++e++ + + e
   EFC36571.1 110 VGISLEIQATDKSEVEASVVIE 131
                  ****************988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (138 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       467  (0.0260472); expected 358.6 (0.02)
Passed bias filter:                      286  (0.0159518); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.34s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 837.10
//
Query:       EFC36572.1  [L=301]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0058   16.9   4.0       0.13   12.5   4.0    2.5  1  RhoGEF    RhoGEF domain


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   4.0   7.1e-06      0.13     141     182 .]     111     152 ..       8     152 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.1e-06
                 HHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHHHHH CS
      RhoGEF 141 qRlprYpLLLkellkntpeshpdyealkkaleaikevaseiN 182
                  R+prY+L+++e+lk  ++++ + + ++ +le++ke+++ iN
  EFC36572.1 111 GRMPRYKLIFDEFLKRESDEQIKIRIINPILEKLKEICTIIN 152
                 6******************99999**************9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       844  (0.0470746); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.33s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 1725.16
//
Query:       EFC36573.1  [L=261]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.8e-46  156.0   0.0    8.4e-46  155.5   0.0    1.2  1  Ras          Ras family
    1.1e-26   93.4   0.1    2.6e-26   92.2   0.0    1.6  2  Roc          Ras of Complex, Roc, domain of DAPkinase
    6.8e-11   41.9   0.0    9.4e-11   41.5   0.0    1.1  1  Arf          ADP-ribosylation factor family
      4e-05   23.7   0.0    6.8e-05   22.9   0.0    1.5  1  MMR_HSR1     50S ribosome-binding GTPase
    9.8e-05   21.8   0.0    0.00014   21.3   0.0    1.2  1  Gtr1_RagA    Gtr1/RagA G protein conserved region
     0.0078   15.8   0.3       0.18   11.3   0.3    2.3  1  FeoB_N       Ferrous iron transport protein B
      0.008   16.1   0.1       0.45   10.4   0.0    2.2  2  RsgA_GTPase  RsgA GTPase
     0.0095   15.7   0.1        1.3    8.8   0.0    2.3  2  PduV-EutP    Ethanolamine utilisation - propanediol utilisati
  ------ inclusion threshold ------
      0.013   14.9   0.0      0.026   14.0   0.0    1.4  1  SRPRB        Signal recognition particle receptor beta subuni
      0.024   14.2   0.0      0.058   12.9   0.0    1.6  2  GTP_EFTU     Elongation factor Tu GTP binding domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  155.5   0.0   4.7e-49   8.4e-46       1     157 [.      59     214 ..      59     218 .. 0.98

  Alignments for each domain:
  == domain 1  score: 155.5 bits;  conditional E-value: 4.7e-49
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++lvG++ vGKt+l +r +k+ F ++y +Tig+df +k+ ++ +   +l +wDTAGqe+fksl ++y r+a++++l++d++  ++++ v+ w++++k+
  EFC36573.1  59 KVILVGETMVGKTCLFVRITKNVFGSNYRPTIGMDFNIKKYKIYDIPFSLVLWDTAGQERFKSLSTSYHRGASACILTFDLNAPDTLHAVRGWYNQVKT 157
                 99************************************************************************************************* PP

                 HST.TTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHHHHHHHH CS
         Ras 100 vae.envpivLvGnKvDleekravsteegeelakelglkfletSAktnenveeafeell 157
                 +ae  n++ +LvG+K+Dl   ++v++ e+++la+el++++ e+S k+  nv+++f++++
  EFC36573.1 158 HAEePNIKWYLVGTKCDLV--KHVDEVEVKQLAEELKAEYWEVSSKEGINVDKLFNRIA 214
                 **9879************9..59********************************9986 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.2   0.0   1.4e-29   2.6e-26       1     120 []      59     175 ..      59     175 .. 0.87
   2 ?   -2.7   0.0       3.6   6.5e+03      45      67 ..     180     202 ..     176     212 .. 0.69

  Alignments for each domain:
  == domain 1  score: 92.2 bits;  conditional E-value: 1.4e-29
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 Kv+lvG++ vGKt+l+ r++++ f +++++tig+df  k++ ki  +        ++l +WDtaGqerf+sl ++y r+a+++il +d    ++ + ++
  EFC36573.1  59 KVILVGETMVGKTCLFVRITKNVFGSNYRPTIGMDFNIKKY-KIYDI-------PFSLVLWDTAGQERFKSLSTSYHRGASACILTFDlnaPDTLHAVR 149
                 9***********************************99986.44432.......4889******************************64334557889 PP

                 HHHHHHHHHCS..SS-EEEEEE-TTT CS
         Roc  97 eWlkelkkvag..kspvilvgnkiDl 120
                  W++++k++a+  +++  lvg+k+Dl
  EFC36573.1 150 GWYNQVKTHAEepNIKWYLVGTKCDL 175
                 9*******9982245668******95 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3.6
                 GGCTTBTTTTCEEEEEEEE-SGG CS
         Roc  45 kgvendkkvkkvklniWDtaGqe 67 
                 ++ve ++  +++k + W ++ +e
  EFC36573.1 180 DEVEVKQLAEELKAEYWEVSSKE 202
                 45555556677888888888777 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.5   0.0   5.2e-14   9.4e-11      14     164 ..      57     209 ..      45     218 .. 0.87

  Alignments for each domain:
  == domain 1  score: 41.5 bits;  conditional E-value: 5.2e-14
                 EEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSS..EEEEEEEETTEEEE..EEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHH CS
         Arf  14 elrilllGLDnaGKtTilkklkleelvt.tvPTig..fnveeleiknlkft..vwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLkal 107
                 e +++l+G    GKt +  +++++ + +   PTig  fn+++ +i ++ f+  +wD  Gqe+ ++l  +Y +   a i   D +  + l+  +   +++
  EFC36573.1  57 EGKVILVGETMVGKTCLFVRITKNVFGSnYRPTIGmdFNIKKYKIYDIPFSlvLWDTAGQERFKSLSTSYHRGASACILTFDLNAPDTLHAVRGWYNQV 155
                 789*******************999865389**986689999999998765327********************************************* PP

                 CTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTH CS
         Arf 108 leeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgegl 164
                  ++ e  ++++ +++ K Dl + ++e e+++l +  elk ++ +e+ +   ++ ++l
  EFC36573.1 156 KTHAEEPNIKWYLVGTKCDLVKHVDEVEVKQLAE--ELK-AEYWEVSSKEGINVDKL 209
                 *************************999998764..566.66888877766666655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.0   3.8e-08   6.8e-05       1      87 [.      59     146 ..      59     201 .. 0.72

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 3.8e-08
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETT..EEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.....T CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkg..keielvDtpGliegaseekglgkaflaleeadlillvvdas.....e 87 
                 +v++vG + vGK+ L+ ++t+++   + +p    d n +++k+ +   +++l+Dt+G  e   + k+l+ ++++   a++ +l +d++     +
  EFC36573.1  59 KVILVGETMVGKTCLFVRITKNVFGSNYRPTIGMDFNIKKYKIYDipFSLVLWDTAG-QE---RFKSLSTSYHR--GASACILTFDLNapdtlH 146
                 699*******************998888888888888888886663466899*****.44...34467777764..466777777766433330 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.0   7.6e-08   0.00014       1     142 [.      59     193 ..      59     224 .. 0.74

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 7.6e-08
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtl.rlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletl 98 
                 kv+L+G+   GKt++   i +n+   + + ++g+  +++k ++       l lwD  Gqe+f   +      +  r  ++ i  fD +  +  ++++ +
  EFC36573.1  59 KVILVGETMVGKTCLFVRITKNVFGSNYRpTIGMDFNIKKYKI-YDIPFSLVLWDTAGQERFKSLS-----TSYHRGASACILTFDLNAPDTLHAVRGW 151
                 89*********************99987735777777777777.455679**********997765.....5556778999*******77777777777 PP

   Gtr1_RagA  99 keilealrqyspeakvfvlihKmDliqedereeifeerkeeire 142
                  + +++ +  +p++k      K+Dl+++  + e+ +  +ee++ 
  EFC36573.1 152 YNQVKT-HAEEPNIKWYLVGTKCDLVKHVDEVEVKQ-LAEELKA 193
                 777654.45689999999999****98665555433.3333333 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.3    0.0001      0.18       2     155 ..      59     212 ..      58     213 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.0001
                 EEEEEESTTSSHHHHHHHHHTTSEEEEES.TTSSSEEEEEEEEETTEEEEEEE----SSSSSSSHHHHHHHHHHH..CTSSSEE....EEEEEGGGHHH CS
      FeoB_N   2 tvalvGnpnvGkttlfnaltgakqkvgNw.pGvtvekkegklklkgkeveivDlPGiYslsayseeekvardfll..eeepdvv....vnvvdatnler 93 
                 +v+lvG+  vGkt lf ++t+     +N+ p + ++ +        k+++i+D+P    l +++ +e+         +    ++    +n  d+ +  r
  EFC36573.1  59 KVILVGETMVGKTCLFVRITKN-VFGSNYrPTIGMDFN-------IKKYKIYDIPFSLVLWDTAGQERFKSLSTSyhRGASACIltfdLNAPDTLHAVR 149
                 6899***************975.445677233333333.......334455555544444444444433221111101111111111156667777778 PP

                 HHH..HHHHHHHTTSSEEEEEETHHHHHHTTEEE-HHHHHHHHTS-EEEEBTTTTBTHHHHHHH CS
      FeoB_N  94 nLy..LtlqllelgvpvvlalnmideaekkgieidlkkLsekLgvpvvktsakkkegieellka 155
                   y  + +   e +++  l+  ++d +++   e+++k+L+e+L+ +  ++s+k++ ++++l ++
  EFC36573.1 150 GWYnqVKTHAEEPNIKWYLVGTKCDLVKH-VDEVEVKQLAEELKAEYWEVSSKEGINVDKLFNR 212
                 77733445566778888888888887764.5688999999999999999999999998888775 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.027        48      99     122 ..      57      80 ..      12     130 .. 0.80
   2 !   10.4   0.0   0.00025      0.45      40      97 ..     157     213 ..     141     216 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.027
                  TSEEEEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase  99 dktsvlvGqSGvGKStLinallpe 122
                  +  ++lvG++ vGK+ L  +++ +
   EFC36573.1  57 EGKVILVGETMVGKTCLFVRITKN 80 
                  445799**********99887765 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00025
                  HHHHHTT-EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHC CS
  RsgA_GTPase  40 vlaeekgiepvivlnKiDlleeeeeleelkeelealgyevllvsaktkegleelkell 97 
                  ++aee +i+  +v +K+Dl+++ +   e+k+  e+l  e   vs+k++ ++++l +++
   EFC36573.1 157 THAEEPNIKWYLVGTKCDLVKHVD-EVEVKQLAEELKAEYWEVSSKEGINVDKLFNRI 213
                  579999*****************9.77889999999999*******999999998765 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0   0.00072       1.3       2      25 ..      58      81 ..      57     105 .. 0.79
   2 ?    4.9   0.0     0.012        21      97     141 ..     171     213 ..     143     215 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00072
   PduV-EutP  2 kkilliGkvgsGKttLtqalkgee 25
                 k++l+G++ +GKt L  +++++ 
  EFC36573.1 58 GKVILVGETMVGKTCLFVRITKNV 81
                59**************99998754 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.012
   PduV-EutP  97 tkidlaedeenieaveelLksaGaekifevsavekegieellkyl 141
                 tk dl+++ +++e+  ++L +   ++ +evs+ e +++++l++ +
  EFC36573.1 171 TKCDLVKHVDEVEV--KQLAEELKAEYWEVSSKEGINVDKLFNRI 213
                 99****99898887..66777777899**************9987 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   1.4e-05     0.026       5      64 ..      59     121 ..      56     141 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.4e-05
                 EEEEE-STTSSHHHHHHHHHHS....S---B---SS-EEETTG...GGTT-SEEEETT-GCCSH CS
       SRPRB   5 avllvGlsdsGKTslftrLttd....svkktvtSqessaalkvksekgskltliDfPGheklrq 64 
                 +v+lvG +  GKT lf r+t++    ++++t     +   +k+  +  ++l l D  G+e++++
  EFC36573.1  59 KVILVGETMVGKTCLFVRITKNvfgsNYRPTIGMDFNIKKYKI-YDIPFSLVLWDTAGQERFKS 121
                 69*******************9777555666544455556666.66778888889999888875 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.2   2.2e+03       6      25 ..      60      79 ..      59      86 .. 0.82
   2 ?   12.9   0.0   3.3e-05     0.058      70     157 ..     106     198 ..      89     252 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.2
                EEEEESTTSSHHHHHHHHHH CS
    GTP_EFTU  6 igiighvDhGKtTLtdrLly 25
                ++++g +  GKt+L  r+++
  EFC36573.1 60 VILVGETMVGKTCLFVRITK 79
                567888899*****988875 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 3.3e-05
                 EEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETT.....TBSTHHHHHHHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  70 ylinliDtPGHvdFskevirglrvlDgavlvvdav.....eGvepqteevlrlalkegvpiivfiNKmDrlkaelkeiveevkqklsrkeekl 157
                 + + l Dt G + F +  +   r +  ++l +d +     + v    ++v  +a + +++  ++ +K+D +k+  +  v+++ ++l+++  ++
  EFC36573.1 106 FSLVLWDTAGQERFKSLSTSYHRGASACILTFDLNapdtlHAVRGWYNQVKTHAEEPNIKWYLVGTKCDLVKHVDEVEVKQLAEELKAEYWEV 198
                 567788***************************99666654477777777788999***************6666666666666664432222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       830  (0.0462937); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1549.19
//
Query:       EFC36574.1  [L=832]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.6e-38  128.2   1.3    0.00027   20.8   0.2   10.8 10  NHL           NHL repeat
    2.4e-07   30.6   0.2        3.2    7.3   0.0    5.5  4  SGL           SMP-30/Gluconolactonase/LRE-like region
    6.9e-07   29.5  30.5    0.00015   22.0  11.8    2.6  2  EGF_2         EGF-like domain
    0.00022   21.3   0.5        7.4    6.4   0.0    4.8  5  Phytase-like  Esterase-like activity of phytase
  ------ inclusion threshold ------
        0.3   11.0   3.0        8.4    6.4   0.0    3.8  4  DUF1533       Protein of unknown function (DUF1533)
       0.51   10.3   3.2         20    5.1   0.1    3.3  3  YSIRK_signal  YSIRK type signal peptide
       0.77    9.8  10.4       0.96    9.5   0.1    4.6  4  SBBP          Beta-propeller repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.1   0.00022      0.57       3      27 ..      63      87 ..      62      88 .. 0.91
   2 !    7.4   0.0    0.0018       4.7       6      26 ..     176     197 ..     171     199 .. 0.80
   3 !   17.2   0.0   1.5e-06    0.0038       3      27 ..     230     254 ..     230     255 .. 0.95
   4 !   12.7   0.0     4e-05       0.1       7      27 ..     346     366 ..     344     367 .. 0.90
   5 !   18.4   0.0   6.3e-07    0.0016       4      27 ..     396     419 ..     395     420 .. 0.93
   6 ?    0.7   0.0      0.26   6.6e+02       8      26 ..     440     459 ..     440     461 .. 0.80
   7 ?    3.2   0.0     0.039     1e+02       9      27 ..     500     518 ..     498     519 .. 0.90
   8 !   17.0   0.0   1.7e-06    0.0043       1      27 [.     555     581 ..     555     582 .. 0.94
   9 !    5.7   0.0    0.0067        17       6      22 ..     616     632 ..     615     634 .. 0.90
  10 !   20.8   0.2   1.1e-07   0.00027       1      27 [.     665     691 ..     665     692 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00022
                SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrvqv 27
                +P +v + +nGd+++aD  + ++++
  EFC36574.1 63 RPVSVKIAQNGDVFIADHDHYTIRK 87
                6999**************9998875 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0018
                 EEEEE.TTTEEEEEECCCTEEE CS
         NHL   6 Gvavd.snGdiyVaDsenhrvq 26 
                 ++a    +G+iy ++++nh+++
  EFC36574.1 176 SIAQHpVTGEIYLSETGNHTIR 197
                 56666678************97 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 1.5e-06
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                 +P+++a +++G+++++D +n+r+++
  EFC36574.1 230 FPSSIAFNNGGELFISDLGNNRIRK 254
                 69*********************87 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 4e-05
                 EEEETTTEEEEEECCCTEEEE CS
         NHL   7 vavdsnGdiyVaDsenhrvqv 27 
                 ++ ++nG++y+a+  n+r+++
  EFC36574.1 346 ISFSPNGELYIANEWNNRIRK 366
                 7789***************97 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 6.3e-07
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P+Gv++++nGd+++aDs++  +++
  EFC36574.1 396 PQGVSITPNGDVLIADSKHALIRK 419
                 9******************99986 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.26
                 EEE.TTTEEEEEECCCTEEE CS
         NHL   8 avd.snGdiyVaDsenhrvq 26 
                 a++ +nGdiy aD   +r++
  EFC36574.1 440 AIMrPNGDIYFADQDENRIR 459
                 67779*****9997777776 PP

  == domain 7  score: 3.2 bits;  conditional E-value: 0.039
                 EETTTEEEEEECCCTEEEE CS
         NHL   9 vdsnGdiyVaDsenhrvqv 27 
                  +s G+i+ +D en+r+++
  EFC36574.1 500 FNSKGEILFTDLENQRIRK 518
                 5799*************86 PP

  == domain 8  score: 17.0 bits;  conditional E-value: 1.7e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P G++v+++++iy  D +n+r+++
  EFC36574.1 555 LNSPYGIVVTPSDEIYLVDKGNFRIRK 581
                 78999********************97 PP

  == domain 9  score: 5.7 bits;  conditional E-value: 0.0067
                 EEEEETTTEEEEEECCC CS
         NHL   6 GvavdsnGdiyVaDsen 22 
                 G+av+s Gdiy +D+++
  EFC36574.1 616 GLAVSSKGDIYFTDNYR 632
                 9**********999875 PP

  == domain 10  score: 20.8 bits;  conditional E-value: 1.1e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f  P G+avdsn+++++aD +n r+++
  EFC36574.1 665 FDAPLGIAVDSNDNVFIADVNNDRIRK 691
                 5669******************99986 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.012        30      46     216 ..      68     261 ..      41     266 .. 0.79
   2 !    7.3   0.0    0.0012       3.2      11     115 ..     295     466 ..     286     484 .. 0.59
   3 !    5.5   0.0    0.0043        11       9     103 ..     501     629 ..     494     643 .. 0.66
   4 !    5.3   0.1    0.0051        13     186     210 ..     668     692 ..     654     698 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.012
         SGL  46 iaprkdgrlvvasksglalldlasgeletladeee...........dekpllrfNDgvvdpdGrlwfGtmgdeeakgeevgalyrldpdgk......le 127
                  +  ++g + +a +++  + ++++g+++t+a +              +  l  + D+   + G+l f + g + +k +++g l  l ++g+        
  EFC36574.1  68 KIA-QNGDVFIADHDHYTIRKVSNGKVSTIAGKNLvqgdsgdgtlaANALLSGPSDLLLTSSGELLFMDGGPRLKKIDKNGFLTCLAGNGSeilpdgFP 165
                 444.66888888888888888888888888888334455666666655578888899999999999988888888888888888888885557777788 PP

         SGL 128 rvlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                    +++t    +a  p +  +Yl ++ +++i +++ + +  ++     f + ++ g+        p ++a  + G++++  +g+++++++d++G +
  EFC36574.1 166 AKDTRFTSIASIAQHPVTGEIYLSETGNHTIRRISTNGNVYTVAGTGEFgFSGDGGPafdaqlFFPSSIAFNNGGELFISDLGNNRIRKIDKNGII 261
                 888899999999999999999999999999999999999999999999977777777888877559999999999999999999999999999954 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0012
         SGL  11 egaLlwvDilgqrihrldpatgketv................................................................ldtpe.... 41 
                 +g L +vDi + ri ++++++  +t                                                                 +d+++    
  EFC36574.1 295 SGDLTFVDINNYRIRKISNKGIISTIagngekgsigdggsalnaqiyysvsisfspngelyianewnnrirkislsgiistysggtfgdgYDASSwgvl 393
                 566666666666666666666666656666666666666655544444444444444444444444444444444444444455555555444443344 PP

         SGL  42 ..svGaiaprkdgrlvvasksglalldlasgeletladeeedekpllrfNDgvvdpdGrlwfGtmgdeeakgeev..g 115
                   + G+ +  ++g +++a +++ ++ +l++g l+t+++++e    l  +  + + p+G ++f + ++++ ++ +   g
  EFC36574.1 394 flPQGVSIT-PNGDVLIADSKHALIRKLSNGVLSTIYTKTE----LRNPTSAIMRPNGDIYFADQDENRIRKISAtdG 466
                 444444444.6677777777777777999999999999854....456777889999999999999888777655555 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0043
         SGL   9 eeegaLlwvDilgqrihrldpatgketv........................ldtpesvGaiaprkdgrlvvasksglall.dlasgeletlade.ee. 80 
                 + +g++l++D  +qri ++ +++   tv                        + ++++ G+++  +++++++  k+++++   l++g++ t+a   ++ 
  EFC36574.1 501 NSKGEILFTDLENQRIRKVALNGSVLTVagfsagingtiapsysgdgglatqAGLNSPYGIVVT-PSDEIYLVDKGNFRIRkILTNGTIITVAGTgTQg 598
                 5688999************999999999777777777777777777776544555557777777.7777777777777776434445554444442223 PP

         SGL  81 .....dekpllrfN...DgvvdpdGrlwfGt 103
                      +  + +r+N    ++v+++G ++f++
  EFC36574.1 599 flgdgGLATAARINprgGLAVSSKGDIYFTD 629
                 4444444455555532245667777777665 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.0051
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrf 210
                 p G+avD+++nv++A +++++++++
  EFC36574.1 668 PLGIAVDSNDNVFIADVNNDRIRKI 692
                 559******************9987 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0  11.8   5.9e-08   0.00015       3      32 .]     717     746 ..     716     746 .. 0.91
   2 !   12.9  10.8   4.2e-05      0.11       5      32 .]     759     785 ..     751     785 .. 0.87

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 5.9e-08
       EGF_2   3 as.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ ++ C+g+G+C++++ +C C+++y+G++C
  EFC36574.1 717 NNvSSVCSGRGSCNDPN-NCTCQANYYGNNC 746
                 556889********999.8************ PP

  == domain 2  score: 12.9 bits;  conditional E-value: 4.2e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+C++    C+C+ + +G++C
  EFC36574.1 759 SSVCSGSGQCIAHD-TCKCSGKAYGANC 785
                 789*******9677.8************ PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0       0.1   2.6e+02      72     100 ..     176     205 ..     161     215 .. 0.87
   2 !    6.4   0.0    0.0029       7.4      72     100 ..     233     261 ..     207     271 .. 0.86
   3 !    5.1   0.0    0.0073        19      72      99 ..     345     372 ..     330     376 .. 0.93
   4 ?   -1.1   0.0      0.58   1.5e+03      76     100 ..     443     468 ..     437     472 .. 0.86
   5 ?    0.3   0.0      0.21   5.5e+02      72     103 ..     560     591 ..     499     642 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.1
  Phytase-like  72 giav.apdgtfwvssEggpfilefdadGkl 100
                   +ia  + +g++++s+ g++ i++++ +G++
    EFC36574.1 176 SIAQhPVTGEIYLSETGNHTIRRISTNGNV 205
                   56666789********************97 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0029
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkl 100
                   +ia++++g++++s+ g+++i+++d++G +
    EFC36574.1 233 SIAFNNGGELFISDLGNNRIRKIDKNGII 261
                   8*************************965 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0073
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGk 99 
                   +i ++p+g+++++ E +++i++++++G 
    EFC36574.1 345 SISFSPNGELYIANEWNNRIRKISLSGI 372
                   78999*******************9985 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 0.58
  Phytase-like  76 apdgtfwvssEggpfilefdad.Gkl 100
                    p+g++++++  +++i++++a+ G++
    EFC36574.1 443 RPNGDIYFADQDENRIRKISATdGTV 468
                   599*****************987765 PP

  == domain 5  score: 0.3 bits;  conditional E-value: 0.21
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkllre 103
                   gi+v+p +++++++ g+ +i+++  +G++++ 
    EFC36574.1 560 GIVVTPSDEIYLVDKGNFRIRKILTNGTIITV 591
                   89999999999999999999999999988765 PP

>> DUF1533  Protein of unknown function (DUF1533)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0         2   5.2e+03       7      18 ..     195     206 ..     188     211 .. 0.59
   2 ?    2.6   0.1      0.05   1.3e+02       2      21 ..     358     377 ..     357     390 .. 0.86
   3 ?    6.4   0.0    0.0033       8.4       6      30 ..     514     538 ..     513     542 .. 0.89
   4 ?   -3.6   0.1       4.4   1.1e+04       8      18 ..     579     589 ..     578     595 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2
     DUF1533   7 aIsevtvNGkkl 18 
                  I+ ++ NG ++
  EFC36574.1 195 TIRRISTNGNVY 206
                 455566666655 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.05
     DUF1533   2 eawrnaIsevtvNGkklenn 21 
                 ++w n+I+++++ G + +++
  EFC36574.1 358 NEWNNRIRKISLSGIISTYS 377
                 68************998765 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0033
     DUF1533   6 naIsevtvNGkklennkyslssigk 30 
                 ++I++v +NG++l+ + +s+++ g 
  EFC36574.1 514 QRIRKVALNGSVLTVAGFSAGINGT 538
                 78***************99999885 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 4.4
     DUF1533   8 IsevtvNGkkl 18 
                 I++++ NG+++
  EFC36574.1 579 IRKILTNGTII 589
                 99999999987 PP

>> YSIRK_signal  YSIRK type signal peptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.014        35       5      19 ..      82      96 ..      80      98 .. 0.82
   2 ?    5.1   0.1    0.0079        20       8      17 ..     417     426 ..     417     428 .. 0.86
   3 ?   -3.0   0.2       2.8   7.1e+03      14      21 ..     466     473 ..     466     474 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.014
  YSIRK_signal  5 rYSIRKlSVGvaSVl 19
                  +Y IRK S G +S +
    EFC36574.1 82 HYTIRKVSNGKVSTI 96
                  9*******9977765 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0079
  YSIRK_signal   8 IRKlSVGvaS 17 
                   IRKlS Gv S
    EFC36574.1 417 IRKLSNGVLS 426
                   9******966 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 2.8
  YSIRK_signal  14 GvaSVliG 21 
                   G++S++ G
    EFC36574.1 466 GTVSIIAG 473
                   9****977 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.3     0.062   1.6e+02      18      29 ..     199     208 ..     187     213 .. 0.74
   2 ?    0.2   0.3       0.3   7.8e+02       9      29 ..     336     357 ..     327     357 .. 0.83
   3 ?   -0.6   0.0      0.55   1.4e+03      17      27 ..     616     626 ..     607     628 .. 0.89
   4 ?    9.5   0.1   0.00037      0.96      17      29 ..     670     682 ..     668     682 .. 0.94

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.062
        SBBP  18 IavDsnGNiYvt 29 
                 I   +nGN+Y++
  EFC36574.1 199 I--STNGNVYTV 208
                 4..79*****97 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.3
        SBBP   9 pgast.ygngIavDsnGNiYvt 29 
                  +a++ y  +I + +nG  Y++
  EFC36574.1 336 LNAQIyYSVSISFSPNGELYIA 357
                 567776999***********97 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.55
        SBBP  17 gIavDsnGNiY 27 
                 g+av s G iY
  EFC36574.1 616 GLAVSSKGDIY 626
                 79********* PP

  == domain 4  score: 9.5 bits;  conditional E-value: 0.00037
        SBBP  17 gIavDsnGNiYvt 29 
                 gIavDsn N++++
  EFC36574.1 670 GIAVDSNDNVFIA 682
                 8**********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (832 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       604  (0.0336884); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.50
# Mc/sec: 4972.78
//
Query:       EFC36575.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-43  149.8   0.0    1.5e-43  149.5   0.0    1.0  1  IU_nuc_hydro  Inosine-uridine preferring nucleoside hydrolase


Domain annotation for each model (and alignments):
>> IU_nuc_hydro  Inosine-uridine preferring nucleoside hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  149.5   0.0   8.4e-48   1.5e-43       2     305 .]       4     355 ..       3     355 .. 0.73

  Alignments for each domain:
  == domain 1  score: 149.5 bits;  conditional E-value: 8.4e-48
                   EEEEEE--SHHHHHHHHHHHCT.H...........TTEEEEEEEE-S.SSS-HHHHHHHHHHHHHHHCT.................TT.S-EEEE-S CS
  IU_nuc_hydro   2 kvilDtDpGiDDalAlllalae.s...........peiellgittva.Gnvsleqatrnalrvlealgg.................rddipvyaGae 68 
                   ++ilDtD+G+DD++Al+l+l++ s           + ++l +++tv+  + ++++a+r + r+l+++++                  ++i+++ G++
    EFC36575.1   4 NIILDTDVGFDDVFALCLLLWKmSssggggddddrKMMNLRAVSTVKgLQLDTNHAARIVERILNSCSDlivgdddhkfsslnidpVSSIKIFSGSQ 100
                   79**************8887765479*********99**********55779************88887*****************666******99 PP

                   S-SSSS.....S-SHHHHTT.....TSSTSS-.--SSH......CSCSSHHHHHHHHHHHHCHHTTTT.EEEEECS-SHHHHHHHHHTCCH.HHHEE CS
  IU_nuc_hydro  69 kpllre.....kaaaeihGe.....dGlgdvllpeper......kaesesavdalidaveaareypge.vtlvatGplTNiAlalrldpel.akkvk 147
                   + +l+e     ++ + +  e     d ++        +        +s++  + l d++e++++ p++ +tl++tGplTNiA++l++d+el  +kv 
    EFC36575.1 101 ERILPEhghcfSEGEWFTKEyqyktDNMA--------DllealpLLNSNKEYEKLNDMLEWMKSFPDQyFTLLCTGPLTNIAKLLEMDRELiLRKVG 189
                   98777533332111112222111113332........1333344334444456678999999****999*********************989**** PP

                   EEEEE---SS...S--SS.SSSS-HHHHHSHHHHHHHHHT..S-E....EEEE-HHHHTTSC.HEECHHHHHH..HHCST....CBHHHHHHHHHHH CS
  IU_nuc_hydro 148 rlviMGGaft...arGNv.tpvaEfNifvDPeAAkiVles..apv...kitlvpldvthkvq.alltseevee..laale....kglgafladllef 228
                   +lviMGG+++   ++ +v    +E+N+++D +AA+iVle+  ++v   +i+++ l v +++q  +l+s+ +++  +   +    ++ +++l++ll+ 
    EFC36575.1 190 KLVIMGGSLFnelEQ-DVlLNGSEWNFYCDGKAAEIVLEAfgTKVelmSIYVANLRVLNQEQiKELASHVHSDraV---QqdelEPIRRMLKKLLTI 282
                   **********66422.221247****************99874445678888888888866654444444444211...12223444449*****99 PP

                   HHHHHHHHHHSSEEE-HHHHHHHHHH-GGGEEEEEEEEEEESSSSTTTTEEE.EETSTT....TTS--EEE..EEEE-HHHHHH CS
  IU_nuc_hydro 229 yikaykeaegsdgaplhDplavavaldpelvttkrlavdveleggltrGrtv.vdlrrl....kkaknvkv..atevdverfle 305
                    +++y+           Dp+a+ ++++p++++ ++++v+v + +++  G    v++ ++    ++ k+v++  a ++++++f+e
    EFC36575.1 283 SFDSYA----------YDPVAATYLFNPSFFEMRNVKVKVYS-EKPLEGLIKeVEYLKTdlerNSGKEVEItaACGFNRDAFFE 355
                   999776..........6**************98988888844.44555533222222225566666666666699999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       596  (0.0332422); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2169.32
//
Query:       EFC36576.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      4e-15   54.5  13.2    0.00018   21.3   0.1    4.9  5  LRR_6       Leucine Rich repeat
      5e-14   52.2  31.4    1.4e-06   28.6   3.6    3.9  5  LRR_4       Leucine Rich repeats (2 copies)
    3.6e-12   45.9  11.3    8.9e-07   28.6   1.3    3.1  3  LRR_8       Leucine rich repeat
    7.3e-06   25.8   9.2          8    7.4   0.1    5.5  5  LRR_1       Leucine Rich Repeat
  ------ inclusion threshold ------
      0.076   13.0   4.1        3.9    7.5   0.0    3.7  3  ApoB100_C   Apolipoprotein B100 C terminal
       0.66    9.8   7.5      0.061   13.2   3.0    1.7  2  Beta_helix  Right handed beta helix region


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.3         4   1.2e+04      12      18 ..      25      31 ..      24      31 .. 0.76
   2 !   11.5   0.0   8.3e-05      0.25       5      18 ..     136     149 ..     133     155 .. 0.84
   3 !   21.2   0.1   6.6e-08    0.0002       5      22 ..     160     177 ..     157     178 .. 0.91
   4 !   21.3   0.1     6e-08   0.00018       5      24 .]     184     203 ..     181     203 .. 0.92
   5 !    7.3   0.0    0.0019       5.7       5      16 ..     208     219 ..     205     226 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4
       LRR_6 12 gNdIgDe 18
                 N+I+ e
  EFC36576.1 25 NNNIDTE 31
                6999976 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 8.3e-05
       LRR_6   5 LteLdLsgNdIgDe 18 
                 L +L++s N+IgDe
  EFC36576.1 136 LASLNISNNEIGDE 149
                 679**********9 PP

  == domain 3  score: 21.2 bits;  conditional E-value: 6.6e-08
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+s N IgDeG++ 
  EFC36576.1 160 LTSLDISNNLIGDEGLKF 177
                 9**************985 PP

  == domain 4  score: 21.3 bits;  conditional E-value: 6e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s N I+DeG++ L+
  EFC36576.1 184 LTSLDISNNLIDDEGLKYLS 203
                 9***************9885 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.0019
       LRR_6   5 LteLdLsgNdIg 16 
                 Lt+L++s N I+
  EFC36576.1 208 LTSLNISNNVIS 219
                 9********996 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.82   2.5e+03       9      17 ..      23      32 ..      21      44 .. 0.56
   2 !   12.6   0.2   4.9e-05      0.15       8      38 ..     116     148 ..     111     155 .. 0.82
   3 !   23.4   2.4   1.9e-08   5.8e-05       2      38 ..     135     172 ..     134     180 .. 0.87
   4 !   28.6   3.6   4.6e-10   1.4e-06       1      38 [.     158     196 ..     158     201 .. 0.84
   5 !   23.4   4.4   1.9e-08   5.7e-05       1      33 [.     182     216 ..     182     220 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.82
                -.SS---E-S CS
       LRR_4  9 s.nNqltdip 17
                s nN++ + +
  EFC36576.1 23 StNNNIDTEE 32
                4477776544 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 4.9e-05
                 --SS---E-S-..HHH.-TT--EEE-.-S----- CS
       LRR_4   8 LsnNqltdipl..lek.lpnLkeLdLsgNnlitd 38 
                 +s N l +i+   + + +++L +L++ +Nn i+d
  EFC36576.1 116 FSRNLLGSIETtkFISeMKQLASLNI-SNNEIGD 148
                 7899*******995555*********.5557765 PP

  == domain 3  score: 23.4 bits;  conditional E-value: 1.9e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +L +L++snN + d +   l+ +++L++Ld+ +Nnli+d
  EFC36576.1 135 QLASLNISNNEIGDEEAkhLGEMKQLTSLDI-SNNLIGD 172
                 5778**********99998888*********.6669977 PP

  == domain 4  score: 28.6 bits;  conditional E-value: 4.6e-10
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++Ld+snN + d +l + + +++L++Ld+ +Nnli+d
  EFC36576.1 158 KQLTSLDISNNLIGDEGLkFINeMKQLTSLDI-SNNLIDD 196
                 58*************99996655*********.6669965 PP

  == domain 5  score: 23.4 bits;  conditional E-value: 1.9e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 ++L++Ld+snN + d +l  l+ +++L++L++s+N
  EFC36576.1 182 KQLTSLDISNNLIDDEGLkyLSEMKQLTSLNISNN 216
                 58*************99998778*********666 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.51   1.5e+03       9      22 ..      52      65 ..      50      72 .. 0.79
   2 !   28.6   1.3     3e-10   8.9e-07       9      61 .]     117     170 ..     110     170 .. 0.94
   3 !   21.9   1.4   3.6e-08   0.00011      24      61 .]     181     218 ..     172     220 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.51
                TTS--SEE-TTSST CS
       LRR_8  9 snNrltslddeaFk 22
                ++  ++ +dd++F 
  EFC36576.1 52 CFEIISMIDDSWFI 65
                5667899*****95 PP

  == domain 2  score: 28.6 bits;  conditional E-value: 3e-10
                 TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   9 snNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 s+N l s++ + F + +++L +L++snN++   +++ +  +++L+sLd+s+N +
  EFC36576.1 117 SRNLLGSIETTKFISeMKQLASLNISNNEIGDEEAKHLGEMKQLTSLDISNNLI 170
                 799**********999************************************87 PP

  == domain 3  score: 21.9 bits;  conditional E-value: 3.6e-08
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +++L++Ld+snNl++    + +s +++L+sL++s+N +
  EFC36576.1 181 MKQLTSLDISNNLIDDEGLKYLSEMKQLTSLNISNNVI 218
                 66777777777777777777777777777777777744 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.69   2.1e+03       7      15 ..      66      74 ..      59      79 .. 0.79
   2 !    6.5   0.0    0.0054        16       2      20 ..     136     154 ..     135     157 .. 0.83
   3 !    6.9   0.1     0.004        12       1      14 [.     159     172 ..     159     180 .. 0.80
   4 !    7.4   0.1    0.0027         8       1      17 [.     183     199 ..     183     205 .. 0.78
   5 !    5.9   0.1    0.0084        25       1      12 [.     207     218 ..     207     227 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.69
       LRR_1  7 Lsnnpllgl 15
                L+n++l+++
  EFC36576.1 66 LNNCSLISK 74
                899999755 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0054
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L +L++snn +++ ++ ++
  EFC36576.1 136 LASLNISNNEIGDEEAKHL 154
                 669********99888877 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.004
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++Ld+snn +++
  EFC36576.1 159 QLTSLDISNNLIGD 172
                 599*******9854 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.0027
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++Ld+snn +++ + 
  EFC36576.1 183 QLTSLDISNNLIDDEGL 199
                 599*******9976655 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.0084
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++snn +
  EFC36576.1 207 QLTSLNISNNVI 218
                 599*******87 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1      0.25   7.5e+02       5      20 ..       5      22 ..       3      28 .. 0.71
   2 ?    7.5   0.0    0.0013       3.9       8      34 ..     115     143 ..     113     146 .. 0.87
   3 ?    3.7   0.2     0.021        62      19      34 ..     176     191 ..     159     212 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.25
   ApoB100_C  5 kLqefs..dqlsdyyEkl 20
                k q+f   dql+++ E +
  EFC36576.1  5 KRQDFQnhDQLINSEEEI 22
                667875338999999976 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0013
   ApoB100_C   8 efsdqlsdyyE..kliaeskrLiDLsIek 34 
                 efs  l+ + E  k+i+e k+L  L I +
  EFC36576.1 115 EFSRNLLGSIEttKFISEMKQLASLNISN 143
                 78888988988668***********9986 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.021
   ApoB100_C  19 kliaeskrLiDLsIek 34 
                 k+i+e k+L  L I +
  EFC36576.1 176 KFINEMKQLTSLDISN 191
                 9********9999987 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.1       3.3   9.8e+03     106     110 ..      24      28 ..      12      33 .. 0.53
   2 ?   13.2   3.0     2e-05     0.061      55     137 ..     137     221 ..      55     224 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 3.3
                 ES-EE CS
  Beta_helix 106 enNii 110
                 +nN+i
  EFC36576.1  24 TNNNI 28 
                 33333 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 2e-05
                 -S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT.--SEE---TT---EEES-EEES- CS
  Beta_helix  55 snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntienNiidnna.gsGividdsssnvtvtnNtitnn 137
                 +  +isnn+i d        +++     i+nn i d g   i+ + + ++++i+nN id+ + ++  ++ +  ++++++nN+i+  
  EFC36576.1 137 ASLNISNNEIGDEEaKHLGEMKQLTSLDISNNLIGDEGLKFINEMkQLTSLDISNNLIDDEGlKYLSEMKQL-TSLNISNNVISEG 221
                 556677777766663333345566667788888888866555444358889999999999995555555555.5999999999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1125  (0.0627475); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1421.84
//
Query:       EFC36577.1  [L=1100]
Description: GCN5-related N-acetyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.9e-57  193.3   0.0    8.3e-57  192.2   0.0    1.5  1  ATP-grasp_5      ATP-grasp domain
    7.1e-36  123.0   0.9    1.7e-34  118.6   0.1    3.3  2  Succ_CoA_lig     Succinyl-CoA ligase like flavodoxin domain
    1.1e-11   44.9   0.0    2.9e-11   43.6   0.0    1.7  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    9.3e-09   36.1   0.0    2.4e-08   34.8   0.0    1.7  1  Acetyltransf_3   Acetyltransferase (GNAT) domain
    1.3e-06   28.1   0.6      1e-05   25.2   0.1    2.5  2  ATP-grasp_2      ATP-grasp domain
    2.8e-06   27.5   0.1    0.00018   21.7   0.1    2.5  2  Acetyltransf_4   Acetyltransferase (GNAT) domain
      5e-06   26.5   0.2    1.9e-05   24.6   0.2    2.0  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    0.00095   19.6   0.1     0.0031   17.9   0.1    1.9  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
     0.0048   16.6   0.0       0.01   15.5   0.0    1.5  1  Acetyltransf_8   Acetyltransferase (GNAT) domain
  ------ inclusion threshold ------
      0.011   15.4   1.8      0.024   14.2   0.0    2.5  3  RimK             RimK-like ATP-grasp domain
      0.026   15.2   1.6       0.14   12.9   0.0    3.0  3  CoA_binding      CoA binding domain
      0.067   14.0   0.1         94    3.9   0.0    3.9  4  GFO_IDH_MocA     Oxidoreductase family, NAD-binding Rossmann 
      0.076   12.5   0.0       0.16   11.4   0.0    1.5  1  CPSase_L_D2      Carbamoyl-phosphate synthase L chain, ATP bi
       0.18   12.1   1.8         10    6.5   0.0    3.4  2  NLRC4_HD         NLRC4 helical domain


Domain annotation for each model (and alignments):
>> ATP-grasp_5  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  192.2   0.0   6.5e-60   8.3e-57       7     222 .]     643     871 ..     638     871 .. 0.92

  Alignments for each domain:
  == domain 1  score: 192.2 bits;  conditional E-value: 6.5e-60
  ATP-grasp_5   7 rtlLteaeakelleaygipvvetrlassaeeaveaaeeigypvvlKivspd.ilhKtdvgGvrlnlkdaeevraaaeeilervkekspeariegvlVq 103
                  ++ L+e+e++ ll+ ygi v++tr+a+saeeaveaa++igypvvlK++  d  + K d+gGv lnl d+++v++ +++i+++v++   + +++gv+Vq
   EFC36577.1 643 KEALNEYESQHLLSLYGIGVPQTRIANSAEEAVEAAKHIGYPVVLKLHNSDtTISKLDLGGVLLNLMDEKQVKQGFNSIKQSVEK--SNVKFTGVTVQ 738
                  789*********************************************8773679****************************99..7889******* PP

  ATP-grasp_5 104 emakr........ggrElivgvteDpvFGpvilfGlGGtavevlkdvavalpplnstlareliertkaskllkg.vrgekkadlaaleellvrlsqLv 192
                  +  k+         + El +g++ D+ FGpvi+fG+GG+  +++kd ++++ppl+  la +l+++tk+s +l + +r+++++d++ l++llvr+s++v
   EFC36577.1 739 SDCKKiatgkrdsISFELYLGSEVDEKFGPVISFGTGGSLHQIYKDKSYGIPPLTAPLAYQLLRKTKISDALVErFRNKPAIDIEGLKSLLVRFSRMV 836
                  9944447777777789*****************************************************999988****99***************** PP

  ATP-grasp_5 193 vdlpe.IreldinPllv....eeegvvalDarirl 222
                   d    I+e +inPl +    +e+ ++alD+r++l
   EFC36577.1 837 LDNSDlIKEFEINPLQAlatdNEKSFTALDCRLTL 871
                  **8778*********8854433355*******986 PP

>> Succ_CoA_lig  Succinyl-CoA ligase like flavodoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.6   0.1   1.3e-37   1.7e-34       1     137 [.     301     428 ..     301     429 .. 0.93
   2 ?   -1.0   0.1       1.1   1.4e+03       3      26 ..     439     462 ..     436     469 .. 0.82

  Alignments for each domain:
  == domain 1  score: 118.6 bits;  conditional E-value: 1.3e-37
  Succ_CoA_lig   1 pGkialisqSGalalalldwaasrglgfskvvslG.neadvdvadlleylaedpetkvillylEsird...grkflsaarraarkkpvvvlksGrse 93 
                   +Gki+++sqSGala+++ldw+ ++g+g+s ++ +G n++dv++ad++e++++dp+t++illy+E++++    ++f+saar++a kkp++++k+++++
    EFC36577.1 301 RGKIGVVSQSGALATTILDWSLKQGVGLSGFACVGaNQTDVNFADMVEHFGNDPNTHAILLYIEDLGNnehIKRFASAARSVALKKPIIAMKMNTNN 397
                   69*********************************55*******************************555599*******************9644 PP

  Succ_CoA_lig  94 agaraaashtgalagsdavvdaafrqaGvlrvdsleelfdaael 137
                   +              +d++++a+f+++G+lrv+s+ee+f + +l
    EFC36577.1 398 R-------------DEDNYLNALFERVGILRVNSIEEMFYMSQL 428
                   3.............57999********************99886 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.1
  Succ_CoA_lig   3 kialisqSGalalalldwaasrgl 26 
                    i +is SG+ a+  +d+  ++++
    EFC36577.1 439 TITVISNSGGAATLAVDAIYQSNI 462
                   4899********999998877665 PP

>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.6   0.0   2.3e-14   2.9e-11      26     117 .]     986    1080 ..     963    1080 .. 0.80

  Alignments for each domain:
  == domain 1  score: 43.6 bits;  conditional E-value: 2.3e-14
                      HHHHSTTC.EEEEEEET.TEEEEEEEEEEEET....TSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHT.TESEEEEEEETTEHHHHHH CS
  Acetyltransf_1   26 esfsleae.gllvaeed.geliGfisllkipd....ekggvayieslaVspeyrgkGlGsaLlealeeraree.gikkivlaveedndaairl 111 
                      ++   + e  l+++ +    +iG+  +++ ++     k+++a++ +l V ++++gkG+G+ Lle+l+++a++e +i  + ++++ +n + ++l
      EFC36577.1  986 DF---DREvVLFAIDKKsKSIIGMGVYTIMQQsivsSKKRKAEL-QLLVGEQAQGKGIGKYLLEQLIHIAKQEgNISQLIAYTHHSNIGVQKL 1074
                      33...333345554444255***************887888888.9***************************55688889************ PP

                      HHHTTE CS
  Acetyltransf_1  112 YeklGF 117 
                       ++ GF
      EFC36577.1 1075 CTRAGF 1080
                      *****9 PP

>> Acetyltransf_3  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.8   0.0   1.9e-11   2.4e-08      38     137 ..     973    1080 ..     956    1081 .. 0.78

  Alignments for each domain:
  == domain 1  score: 34.8 bits;  conditional E-value: 1.9e-11
  Acetyltransf_3   38 eewlera..waeeseeeg.ygwaivlkdtgviGsvglrdleeedee.....aelgymlapsfwgkGyateavralleyafeelglerlvavid 122 
                      +e +++   + + + +++ + +ai +k++++iG+  ++ ++++  +     ael ++++++++gkG+++  +++l+++a +e ++++l+a ++
      EFC36577.1  973 KEIYQELvqYVSSDFDREvVLFAIDKKSKSIIGMGVYTIMQQSIVSskkrkAELQLLVGEQAQGKGIGKYLLEQLIHIAKQEGNISQLIAYTH 1065
                      444444334444444555256999545554688876665555544466889****************************************** PP

  Acetyltransf_3  123 keNeaSirvleklGf 137 
                       +N + +++ +++Gf
      EFC36577.1 1066 HSNIGVQKLCTRAGF 1080
                      **************9 PP

>> ATP-grasp_2  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.45   5.8e+02      74     130 ..     387     449 ..     371     486 .. 0.71
   2 !   25.2   0.1   8.2e-09     1e-05       2     116 ..     646     765 ..     645     777 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.45
                  CCTTSEEE-TTS-TT...-EEE--EEEEE---ECEEEEEEEEEETTT...TEEEEEEESSTTS CS
  ATP-grasp_2  74 ellgkelvtkqtgke...GkkvekvlveealdikkElYlsivlDras...kkvvviaSseGGv 130
                   ++ +++ t+  +++       e+v +     i++ +Y+s ++ +++    + + ++S++GG 
   EFC36577.1 387 PIIAMKMNTNNRDEDnylNALFERVGILRVNSIEEMFYMSQLIGKQAitkGNTITVISNSGGA 449
                  566666666666555111345678888889999999999999999852224577888999996 PP

  == domain 2  score: 25.2 bits;  conditional E-value: 8.2e-09
                  E-HHHHHHHHHCTT----SEEEESSHHHHHHHHHHHTSSSEEEEE--SSSTCCCT..TCEEEESSHHHHHHHHHCCTTSEEE-TTS-TT-EE....E- CS
  ATP-grasp_2   2 lhEyqakeilakygvkvpegevaesaeeaeeaakklgekelvvKaQvlaGGRGKa..gGvklvkskeeakeaakellgkelvtkqtgkeGkk....ve 93 
                  l Ey+++++l+ yg+ vp++++a+saeea eaak++g  + v+K         K   gGv l    e+  +   + + +++     + +G +    ++
   EFC36577.1 646 LNEYESQHLLSLYGIGVPQTRIANSAEEAVEAAKHIGYPV-VLKLHNSDTTISKLdlGGVLLNLMDEKQVKQGFNSIKQSVEKSNVKFTGVTvqsdCK 742
                  89************************************99.999888877777777799987655555444455555666665666666655111157 PP

                  -EEEEE---ECEEEEEEEEEETT CS
  ATP-grasp_2  94 kvlveealdikkElYlsivlDra 116
                  k+   ++  i+ ElYl+  +D +
   EFC36577.1 743 KIATGKRDSISFELYLGSEVDEK 765
                  89999999999999999888865 PP

>> Acetyltransf_4  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.076        97     103     142 ..     651     691 ..     621     694 .. 0.79
   2 !   21.7   0.1   1.4e-07   0.00018      33     134 ..     972    1080 ..     949    1091 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.076
  Acetyltransf_4 103 eqvl.keqnienllaeiaspnensiqfhkalGFelvgifkk 142
                     +q l + ++i    ++ia + e++++ +k++G+ +v ++++
      EFC36577.1 651 SQHLlSLYGIGVPQTRIANSAEEAVEAAKHIGYPVVLKLHN 691
                     555657778888889******************99977765 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 1.4e-07
  Acetyltransf_4   33 sveefekfleal.d..sekeyvflvae.sdrivGyaylg..qfkkr.akdwkaelsvylaerdnnkeglgrelidaleqvl.keqnienllae 117 
                      s+e ++ + +++      +  +f +++ s  i+G+  +   q   +  k+ kael+ ++  ++++ +g+g+ l++ l+ ++ +e ni +l a 
      EFC36577.1  972 SKEIYQELVQYVsSdfDREVVLFAIDKkSKSIIGMGVYTimQQSIVsSKKRKAELQLLVG-EQAQGKGIGKYLLEQLIHIAkQEGNISQLIAY 1063
                      55555555555532334446789999999****9998883344556899**********7.79******************9999******** PP

  Acetyltransf_4  118 iaspnensiqfhkalGF 134 
                      +  +n+  +++  + GF
      EFC36577.1 1064 THHSNIGVQKLCTRAGF 1080
                      ****************9 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.2   1.5e-08   1.9e-05      31     117 ..     992    1092 ..     967    1098 .. 0.69

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 1.5e-08
  Acetyltransf_10   31 alllvaeeggkivGvi..elrdgs........hisllfVdpeyrgqGigkaLleaveeeaekdgikl...eltvnaspyavpfYeklGFkav 109 
                       +l+ + +++++i+G++  +++++s            l V ++++g+Gigk Lle++++ a+++g+     ++t +++   +++  + GF++ 
       EFC36577.1  992 VLFAIDKKSKSIIGMGvyTIMQQSivsskkrkAELQLLVGEQAQGKGIGKYLLEQLIHIAKQEGNISqliAYTHHSNIGVQKLCTRAGFVEQ 1083
                       33333444466666555466555556666664333468*********************9777654457777888888*************9 PP

  Acetyltransf_10  110 .geeqeenG 117 
                        ++e  e+G
       EFC36577.1 1084 dNSELFEQG 1092
                       555555555 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.1   2.4e-06    0.0031      12      75 ..    1001    1081 ..     988    1082 .. 0.58

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.4e-06
                      TEEEEEEEEEEES.........TCTEE..EEE-GGGTTSSHHHHHHHH....TT.SEEE..EEEEEE..THHHHHHHHHHTTEE CS
  Acetyltransf_7   12 gkivGfialslld.........aeitr..laVdpeyrgkGiGraLlea....ae.kgii..leqlel..naekaikfYeklGFe 75  
                      + i+G+ ++++ +             +  l V ++++gkGiG+ Lle     a+ +g i  l+ +++  ++   +k+  + GF+
      EFC36577.1 1001 KSIIGMGVYTIMQqsivsskkrKA--ElqLLVGEQAQGKGIGKYLLEQlihiAKqEGNIsqLI-AYThhSNIGVQKLCTRAGFV 1081
                      556676666666666776554333..1559****************95444411455222222.23321322556677777776 PP

>> Acetyltransf_8  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0     8e-06      0.01      26     142 ..     971    1085 ..     960    1088 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 8e-06
                      --HHHHHHHHHHHC.STTEEEEEEEETT..EEEEEEEEEEGGGCGGGGCS---TT-EEEEEEESSHHHCTTTCHHHHHHHHHHHHHCCTT--E CS
  Acetyltransf_8   26 gtleevrellakldadphsepliglldg..epvgyfeiYwakedelaeyydaepgdrGiHlligeaeargkglttallralvhylfadprtrr 116 
                      +++e  +el +++++d ++e ++  +d   + +  + +Y + ++++      ++    + ll+ge+++ gkg+++ ll++l+h + ++  +++
      EFC36577.1  971 DSKEIYQELVQYVSSDFDREVVLFAIDKksKSIIGMGVYTIMQQSI---VSSKKRKAELQLLVGEQAQ-GKGIGKYLLEQLIHIAKQEGNISQ 1059
                      4556666666777777777777777776333444455677777744...56778888899****9887.************************ PP

                      EEE--BTT-HHHHHHHHHTT-EEEEE CS
  Acetyltransf_8  117 vvvEPdvrNerairllekaGfekeke 142 
                       ++  +++N  + +l+ +aGf+++++
      EFC36577.1 1060 LIAYTHHSNIGVQKLCTRAGFVEQDN 1085
                      **********************9976 PP

>> RimK  RimK-like ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       5.6   7.1e+03       6      26 ..     471     491 ..     470     493 .. 0.86
   2 ?   14.2   0.0   1.9e-05     0.024       3      53 ..     647     695 ..     645     724 .. 0.90
   3 ?   -2.0   0.3       1.8   2.3e+03      45      96 ..     980    1031 ..     978    1036 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 5.6
                 HHHHHHHHTT-----EEEESS CS
        RimK   6 kslklLakakikvpntalard 26 
                 ks klL   +i+v+++ l+ +
  EFC36577.1 471 KSAKLLQESGIDVEEALLSGK 491
                 7999********999998865 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 1.9e-05
                 -HHHHHHHHHHTT-----EEEESS-S-HHHHHHTT-.-SSEEEEE-TTTT- CS
        RimK   3 dKlkslklLakakikvpntalardeedaekliekiklrfPvvvKsvegsqG 53 
                 + + s +lL   +i+vp+t++a++ e+a++  ++i  + Pvv+K  ++ + 
  EFC36577.1 647 NEYESQHLLSLYGIGVPQTRIANSAEEAVEAAKHI--GYPVVLKLHNSDTT 695
                 6788999****************************..69*****9998765 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1.8
                  EEE-TTTT--EEEEE-SHHHHHHHHHHGGG--EEEEE--SS-SEEEEEEEET CS
        RimK   45 vKsvegsqGikvvlakkeqklkqvlealkeailvqeyieeaenediRvlvvd 96  
                  v+ v + +  +vvl    +k k+++     +i++q  +  ++ ++   l v+
  EFC36577.1  980 VQYVSSDFDREVVLFAIDKKSKSIIGMGVYTIMQQSIVSSKKRKAELQLLVG 1031
                  5667888889999999999999999888888999988888777544444445 PP

>> CoA_binding  CoA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   0.00011      0.14      46      93 ..     164     227 ..     131     230 .. 0.76
   2 ?   -1.5   0.1       3.2   4.1e+03      11      72 ..     443     505 ..     436     511 .. 0.74
   3 ?   -2.2   0.1       5.4     7e+03      70      85 ..     662     677 ..     660     680 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 0.00011
                  T........TEEEESCHHHHHHHC...T....TTEEEEES.-HHHHHHHHHHHHHTT-SEEEEE CS
  CoA_binding  46 l........glpvyksvdeleekt...e....vdvavitv.Paesaqeavdelveagikgivii 93 
                  +        g+p+y+s++el+++    +    +d avi+    e    a +e++++g+kg vii
   EFC36577.1 164 KtkrrphllGVPMYPSLSELSASKsteQkkleIDLAVICChQVETMFYALEECIKNGVKGCVII 227
                  344455556**********9887665515688*******96667889***************99 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 3.2
                  TTSHHHHHHHHHHHHHHECEEEEEEC-TTTTT.CEETTEEEESCHHHHHHHCTTTEEEEES-H CS
  CoA_binding  11 agglgiaglyhfkeklkygikavfgvnprkvg.tevlglpvyksvdeleektevdvavitvPa 72 
                  ++++g+a ++ ++  ++ +i++++ ++ + +   + +g+ v +++   ++ ++v++  +++P+
   EFC36577.1 443 ISNSGGAATLAVDAIYQSNITELGAISNKSAKlLQESGIDVEEALLSGKKAIPVNIRNTATPE 505
                  688899999999999999999999999885543455588888877777777777666666665 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 5.4
                  S-HHHHHHHHHHHHHT CS
  CoA_binding  70 vPaesaqeavdelvea 85 
                  vP+++++++++e+vea
   EFC36577.1 662 VPQTRIANSAEEAVEA 677
                  9999**********97 PP

>> GFO_IDH_MocA  Oxidoreductase family, NAD-binding Rossmann fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.095   1.2e+02      39      87 ..     165     221 ..     149     227 .. 0.79
   2 ?    3.9   0.0     0.074        94      43      97 ..     336     390 ..     304     398 .. 0.88
   3 ?    1.1   0.0      0.54   6.9e+02      50      82 ..     507     539 ..     460     549 .. 0.73
   4 ?   -2.8   0.0       8.4   1.1e+04      60      89 ..     652     681 ..     618     688 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.095
                   HHHHHHHTTHEEESSHHHHHTCT.......TESEEEE-S-G.GGHHHHHHHHHHTT- CS
  GFO_IDH_MocA  39 aeavaesfgveaysdleelladp.......eidavivatpn.gtheelakaaleagk 87 
                    ++  + +gv+ y +l+el+a++       eid+++++++  +t +   ++++++g+
    EFC36577.1 165 TKRRPHLLGVPMYPSLSELSASKsteqkklEIDLAVICCHQvETMFYALEECIKNGV 221
                   444567789999***9999998887777667********997777777777777776 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.074
                   HHHTTHEEESSHHHHHTCTTESEEEE-S-GGGHHHHHHHHHHTT-EEEEESSS-S CS
  GFO_IDH_MocA  43 aesfgveaysdleelladpeidavivatpngtheelakaaleagkhvllEKPlat 97 
                   a++++v++ + +e+  +dp+ +a++  +     +e++k+++ a  +v l KP+ +
    EFC36577.1 336 ANQTDVNFADMVEHFGNDPNTHAILLYIEDLGNNEHIKRFASAARSVALKKPIIA 390
                   7888888888899999************************************965 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.54
                   EESSHHHHHTCTTESEEEE-S-GGGHHHHHHHH CS
  GFO_IDH_MocA  50 aysdleelladpeidavivatpngtheelakaa 82 
                    ++ l+ + +dp+ d v+v+  ++t  e ++ a
    EFC36577.1 507 YVAALDIVYNDPKTDSVLVMLTPQTRTEPTRTA 539
                   444588899999***********9988877654 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 8.4
                   CTTESEEEE-S-GGGHHHHHHHHHHTT-EE CS
  GFO_IDH_MocA  60 dpeidavivatpngtheelakaaleagkhv 89 
                   +    ++ +++p +  ++ a++a+ea kh+
    EFC36577.1 652 QHLLSLYGIGVPQTRIANSAEEAVEAAKHI 681
                   335666777888888888888888888776 PP

>> CPSase_L_D2  Carbamoyl-phosphate synthase L chain, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00013      0.16      18      44 ..     664     688 ..     649     695 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00013
                  SEECSSBSSHHHHHHHHHHH-SSEEEE CS
  CPSase_L_D2  18 pssaapvetleealaiakeigyPviik 44 
                  +  +  ++++eea+++ak+igyPv++k
   EFC36577.1 664 QTRI--ANSAEEAVEAAKHIGYPVVLK 688
                  4444..499****************98 PP

>> NLRC4_HD  NLRC4 helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.2      0.12   1.5e+02      53     100 ..     602     656 ..     585     658 .. 0.70
   2 ?    6.5   0.0    0.0078        10      67     107 .]     901     940 ..     877     940 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.12
                 THHCHCH......T--SGGCCHCHHHHHHH.HHHHHHHH-HH..HHHHHHHHHHHH CS
    NLRC4_HD  53 eslenls......endeylkhtpelellkailirslvelspe..lylssvskslLs 100
                 + lenl        nd+  ++++  +   + +i+sl e +p+  ++ +  s++lLs
  EFC36577.1 602 KNLENLYedpsllDNDDASQNESSKQKARE-YIKSLLEKNPNkeALNEYESQHLLS 656
                 556666655566577777777776666666.9*******99722467777888887 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0078
                 CHCHHHHHHH.HHHHHHHH-HHHHHHHHHHHHHHHHHHHHC CS
    NLRC4_HD  67 htpelellkailirslvelspelylssvskslLslaleiaY 107
                   ++ ++  + l++++++lsp+ + ss+ +s+L+   +ia+
  EFC36577.1 901 RPSKFSDFRK-LLSFFTNLSPKTLESSIRESALRSQCSIAF 940
                 4455555556.9***********************999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1100 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       726  (0.0404931); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.61u 0.24s 00:00:00.85 Elapsed: 00:00:00.41
# Mc/sec: 7980.36
//
Query:       EFC36578.1  [L=469]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        4.7    7.0  10.6          7    6.4   0.2    3.9  4  DUF4668   Domain of unknown function (DUF4668)
        6.2    7.1   8.9       0.45   10.8   0.9    2.9  2  DUF2530   Protein of unknown function (DUF2530)


Domain annotation for each model (and alignments):
>> DUF4668  Domain of unknown function (DUF4668)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.2   0.00079         7     118     154 ..       7      43 ..       2      57 .. 0.87
   2 ?    4.2   0.4    0.0037        34      99     146 ..      78     125 ..      72     133 .. 0.88
   3 ?   -2.5   0.0      0.44     4e+03      46      68 ..     140     163 ..     125     167 .. 0.69
   4 ?    0.3   0.4      0.06   5.4e+02      20      53 ..     262     295 ..     257     323 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.00079
     DUF4668 118 ktdqgislerlsqlfqlqlnailitlllaylfkeyel 154
                 k+++gi+++ +s ++++ + +++++  +ay  ke   
  EFC36578.1   7 KESKGIKYSLISTIMVIIFIIMMAMNTFAYGKKEIST 43 
                 6789999********9999999999999999888765 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0037
     DUF4668  99 flllyvslvyslviiqlffktdqgislerlsqlfqlqlnailitllla 146
                  + + v ++y++ i+  +f+   +i + ++++ f+ q++ +++tl+ +
  EFC36578.1  78 WFWVIVKSIYFNAIMSGLFAGAVTIFVTVIIERFGPQIGGVIATLVSF 125
                 57788999********************************99987654 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.44
     DUF4668  46 laiv.sivgflllkerayrkkfkr 68 
                 +aiv + +gf+  ++r+y++ +++
  EFC36578.1 140 SAIVpALIGFAFDANRNYETDEEN 163
                 556624578999999999887765 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.06
     DUF4668  20 plelLkekypkvlkiksvqlildlvylaivsivg 53 
                 + + L +k  k+l +  + li+ +v +a++++v 
  EFC36578.1 262 NKHELLKKIGKMLIVCFLSLIAWFVVAAVFVVVT 295
                 5566666777777666666666665555444443 PP

>> DUF2530  Protein of unknown function (DUF2530)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.9     5e-05      0.45      12      59 ..     272     318 ..     261     322 .. 0.76
   2 ?   -1.4   1.6      0.33   2.9e+03      18      39 ..     415     436 ..     403     453 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 5e-05
     DUF2530  12 dprpvivvgtllWlvalvvllvvgdaleswlpvclaGlvvGllGlaif 59 
                 ++  v  +  ++W+v + v++vv  ++ ++    l+G+ +G+ Gl+i+
  EFC36578.1 272 KMLIVCFLSLIAWFVVAAVFVVV-TKIVKLSDDILMGVSMGFYGLTII 318
                 45556667788998877777766.6788899999************97 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.33
     DUF2530  18 vvgtllWlvalvvllvvgdale 39 
                 v+ ++lW + + ++++vg   +
  EFC36578.1 415 VMCVCLWYMNIALAFLVGYVAS 436
                 4555666666666665533332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (469 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1374  (0.0766356); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.36s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2651.61
//
Query:       EFC36579.1  [L=698]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00014   21.6   0.1    0.00032   20.5   0.1    1.6  1  F-box-like  F-box-like
  ------ inclusion threshold ------
       0.77    9.5   6.9        3.7    7.3   0.1    3.2  4  DUF4303     Domain of unknown function (DUF4303)


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   3.6e-08   0.00032       2      46 ..     457     501 ..     456     502 .. 0.92

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 3.6e-08
  F-box-like   2 srLPdEiLlqIFsyLpps.dLlrlalVCrrWrrvaldtplLWrrlv 46 
                  +LP Ei ++I sy+p   dL++l++  ++W++v  ++  +W+ l+
  EFC36579.1 457 HYLPIEIVMTIASYIPKAiDLTNLMRLDKSWNNVFESN-DVWKYLC 501
                 68*************8777****************999.9**9888 PP

>> DUF4303  Domain of unknown function (DUF4303)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.21   1.9e+03      91     128 ..      69     106 ..      37     113 .. 0.59
   2 ?   -3.3   0.0      0.72   6.5e+03      30      63 ..     123     156 ..     119     158 .. 0.73
   3 ?    4.8   0.1    0.0024        21      69     130 ..     340     400 ..     338     421 .. 0.75
   4 ?    7.3   0.1   0.00042       3.7      62     151 ..     518     614 ..     507     617 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.21
     DUF4303  91 feleekefeafrdklleamvkAlkeldkeglfgkgqdr 128
                   + ++  e++  ++ + + k++k+  +e +  k +d 
  EFC36579.1  69 ANNLSSSSEEEEPSRWSWTQKVMKKWSDERFNRKSADW 106
                 23333377888888888888888888888776666555 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.72
     DUF4303  30 gdalsvsiaanteeaLereaaeykeededelrws 63 
                  +++ +s++ + + +L++   ++ +e +d++ w 
  EFC36579.1 123 KEFKEISLNYAHHVHLKKKNISNRYESSDFYDWV 156
                 5667788888888888888888888888888775 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.0024
     DUF4303  69 yadfgded.fedvnkllaardnefeleekefeafrdklleamvkAlkeldkeglfgkgqdref 130
                 y++ ++ + ++ +++++aa  +++ + + + ++  + +++ m +A+++  ++ lfg +  r++
  EFC36579.1 340 YHIQNNLNsLRFISQQVAANLLSSVVHAIDSNELEKLVFKSMKNAIEQNIDTFLFGIM--RDN 400
                 666666666777777777775554444449999***********************98..444 PP

  == domain 4  score: 7.3 bits;  conditional E-value: 0.00042
     DUF4303  62 wsvadWpyadfgded........fedvnkllaardnefeleekefeafrdklleamvkAlkeldkeglfgkgqdrefivifvvvepedeaeeiesakr 151
                 ++v+dW+y+  +            + ++ ll+a+   f +++ +f++f +++++ +  A k l+++ + + ++ ++ +++++ ++ + + + ie++  
  EFC36579.1 518 FQVDDWKYYVLSRSMfervqfptIKGLDCLLNAFRVKFIDKSTIFKQFVNDFFTNTYIATKTLNDDKMNEYNTMKATLITYWPCQSPLKYD-IEIVLD 614
                 78999999999888766667333344455899*********99************************************999998887777.666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (698 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       681  (0.0379832); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 3969.50
//
Query:       EFC36580.1  [L=223]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.5e-06   26.1   0.0    1.1e-05   25.6   0.0    1.3  1  PTPlike_phytase  Inositol hexakisphosphate
    3.3e-05   23.7   0.0      4e-05   23.4   0.0    1.1  1  DSPc             Dual specificity phosphatase, catalytic doma
    0.00017   21.6   0.0    0.00026   21.1   0.0    1.3  1  Y_phosphatase3   Tyrosine phosphatase family
     0.0035   16.9   0.0     0.0066   16.1   0.0    1.4  1  Y_phosphatase    Protein-tyrosine phosphatase
  ------ inclusion threshold ------
      0.022   14.4   0.0      0.028   14.1   0.0    1.2  1  CDKN3            Cyclin-dependent kinase inhibitor 3 (CDKN3)
      0.086   12.4   0.0       0.11   12.1   0.0    1.3  1  Y_phosphatase2   Tyrosine phosphatase family


Domain annotation for each model (and alignments):
>> PTPlike_phytase  Inositol hexakisphosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.0   3.7e-09   1.1e-05      94     151 ..     116     174 ..      79     176 .. 0.89

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 3.7e-09
                      HHHHTT-EEEEEEE-TTS---HHHHHHHHHHHHTS.-TT-EEEEE-SSSSHHHHHHHHH CS
  PTPlike_phytase  94 laeelslrYaRipitdekapeeedfdalvsilkea.pektalvfnCqmGrgRTTtamvi 151
                      + ++ +l+Y+ +pi d++  e+ ++ +lv +l+++ ++ ++l ++C  G gRT t+ +i
       EFC36580.1 116 KTTRSKLNYVTFPIRDKNIAEDDKVTELVTLLAQLvNRGEVLYVHCVGGHGRTGTVAAI 174
                      567789*****************************999***************999887 PP

>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.0   1.3e-08     4e-05       6     110 ..      76     191 ..      71     211 .. 0.77

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 1.3e-08
                 CCHHC.HHHHHHHTCSEEEEESSSSSEC...........ECCTTTTSEEEEECCESSTTSCCGGGHHHHHHHHHHHHHTT-EEEEEESSSSSHHHHHHH CS
        DSPc   6 kstas.lallsklgitlvinvtkevpna...........nalkkseieklripvedehetkiskyleeavefidkakqkgkkvlVHCqaGisRSatlii 92 
                 +++++  + +   g+t  +n+ +e+++            ++   s+ +++  p++d ++    +   e+v+ ++++ ++g+  +VHC  G  R++t+++
  EFC36580.1  76 YPRSKeVDSIVSSGVTTFVNLVEEDEQLrcgpfyfanalKKTTRSKLNYVTFPIRD-KNIAEDDKVTELVTLLAQLVNRGEVLYVHCVGGHGRTGTVAA 173
                 55555556666677888888887777667888888865545566777788888888.666667789999****************************99 PP

                 HHHHHHHTSCHHHHHHHH CS
        DSPc  93 aYlmktknlslneayefl 110
                   l + +n+s+ + ++ +
  EFC36580.1 174 ILLGQLFNISAYDSLKWV 191
                 998888888888887776 PP

>> Y_phosphatase3  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   8.6e-08   0.00026     101     143 ..     133     177 ..      77     182 .. 0.63

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 8.6e-08
  Y_phosphatase3 101 elle.sakkayrkvfealadee..pvlfHCtaGKDRTGvlaallls 143
                     +++e ++  ++ +++ +l + +   + +HC  G  RTG +aa+ll 
      EFC36580.1 133 NIAEdDKVTELVTLLAQLVN-RgeVLYVHCVGGHGRTGTVAAILLG 177
                     33333334555555666666.3568899***************995 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   2.2e-06    0.0066     136     192 ..     120     176 ..      87     206 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 2.2e-06
                    EEEEESSS-..SSSSGSCCHHHHHHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHHHH CS
  Y_phosphatase 136 kqlqytnWp..dhgvpesaksllklirkvekskeaksgpvvVhCsaGvgRtgtfvaldi 192
                    ++l y + p  d+++  + +++++l++ + +   ++ + + VhC  G gRtgt++a+ +
     EFC36580.1 120 SKLNYVTFPirDKNIA-EDDKVTELVTLLAQLV-NRGEVLYVHCVGGHGRTGTVAAILL 176
                    5556666664344443.3455566666666666.5558899************999865 PP

>> CDKN3  Cyclin-dependent kinase inhibitor 3 (CDKN3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   9.4e-06     0.028     105     158 ..     126     179 ..      78     187 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 9.4e-06
                 E----TTS---HHHHHHHHHHHHHHHHTT--EEEE-SSSSSHHHHHHHHHHHHH CS
       CDKN3 105 hhpiadggtpdiascleimeelatclknyrktlihcygglgrsclvaaclllyl 158
                   pi d    +   ++e++  la  ++      +hc gg gr+  vaa ll  l
  EFC36580.1 126 TFPIRDKNIAEDDKVTELVTLLAQLVNRGEVLYVHCVGGHGRTGTVAAILLGQL 179
                 568888888888899999999988888888888***************999665 PP

>> Y_phosphatase2  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   3.6e-05      0.11      55     113 ..     120     176 ..      60     204 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.6e-05
                     CT-EEEE-------GGG----HHHHHHHHHHHH-GGG-SEEEE-SSSSSHHHHHHHHHH CS
  Y_phosphatase2  55 ekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckrGkhrtglvigclR 113
                      k +++ + i +++     +k ++l+  l  l+n+ +  +++hc  G+ rtg+v ++l 
      EFC36580.1 120 SKLNYVTFPIRDKNI-AEDDKVTELVTLLAQLVNRGE-VLYVHCVGGHGRTGTVAAILL 176
                     444444444444444.444555666667777777766.59***************9984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (223 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       321  (0.017904); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1406.23
//
Query:       EFC36581.1  [L=924]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.8e-49  167.7   0.4    6.8e-49  166.5   0.4    1.7  1  MutS_V       MutS domain V
    1.7e-27   96.9   0.8    4.8e-27   95.4   0.3    2.0  2  MutS_III     MutS domain III
      4e-05   23.9   0.1    0.00013   22.2   0.1    2.0  1  MutS_IV      MutS family domain IV
  ------ inclusion threshold ------
      0.022   15.0   0.0       0.12   12.7   0.0    2.2  2  MutS_II      MutS domain II
      0.064   13.1   6.5        7.6    6.2   1.1    3.8  3  AAA_21       AAA domain, putative AbiEii toxin, Type IV TA sy
       0.78   10.3   5.0        6.6    7.3   2.8    3.1  2  AF0941-like  AF0941-like


Domain annotation for each model (and alignments):
>> MutS_V  MutS domain V
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  166.5   0.4   2.3e-52   6.8e-49       1     187 [.     670     879 ..     670     880 .. 0.91

  Alignments for each domain:
  == domain 1  score: 166.5 bits;  conditional E-value: 2.3e-52
                 EEEE-STTSSHHHHHHHHHHHHHHHHHT--BSSS.EEEEE--SEEEEEE--------SS-HHHHHHHHHHHHHTT--TTSEEEEESTS-SS-HHHHHHH CS
      MutS_V   1 llitGpnmaGkstylrqvalivllaqiGsfvpae.kaeisivdkiftRvgasDdlakgkstFmvEmlEtasilknatekslvilDElGRGtstydGlai 98 
                 ++itGpn +Gks+yl+qv+liv +a+iGsfv a+ ++ i++vd+i+tR+ ++D+++ ++stF +++l ++++++ a+++sl+++DE G+Gt + dG+a+
  EFC36581.1 670 QIITGPNNSGKSCYLKQVGLIVFMAHIGSFVSASpESVIGVVDRIMTRIQSQDSISVSQSTFAIDVLQMKAMVDFASSRSLLLIDEFGKGTLALDGIAL 768
                 59******************************9846779************************************************************ PP

                 HHHHHHHHHHTT--.EEEEEES-GGGGGHH...HHSTTEEEEEEEEE..................EETTEEEEEEEEEES--SS--HHHHHHHTT--HH CS
      MutS_V  99 alavaeyllekika.ktlfatHyheltkla...ekleevknlhlavk..................eeeedivflykvkegaaeksyGikvaklaglPes 175
                   a+++++ e+ +  +++ +tHy e+ + +    + ++++ ++++v                    + ed+vflyk+++g+   syGi+va+laglP++
  EFC36581.1 769 LSAILKHFQEREHVpRVIVTTHYVEVLQHKiidVNSTSIQFMTMDVLidsvnelpndmedehfvvPSAEDLVFLYKLTRGKIIPSYGITVASLAGLPNQ 867
                 ********98776537899******976541113455566677777699***********99998889******************************* PP

                 HHHHHHHHHHHT CS
      MutS_V 176 vverArevlkel 187
                 ++erA+ v+++l
  EFC36581.1 868 IIERAKFVAERL 879
                 *****9998877 PP

>> MutS_III  MutS domain III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.4   0.3   1.6e-30   4.8e-27      17     191 .]     333     622 ..     294     622 .. 0.88
   2 ?   -1.7   0.0      0.93   2.8e+03     151     166 ..     815     903 ..     706     923 .. 0.41

  Alignments for each domain:
  == domain 1  score: 95.4 bits;  conditional E-value: 1.6e-30
                 SSS.-HHHHH---SSHHHHHHHHHHHH--BS-HHHHHHHHHHHHHT....TT.HHHHHHHHTT---HHHHHHHHHTT---HHHHHHHHHHHHHHHTTTT CS
                 xxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    MutS_III  17 keg.sLlgvldrTvTamGaRlLrewllqPltdleeInaRldaVeele..neelreelrellrrlpDleRllsrislgkakardlkallealkaleelva 112
                 keg sL+g++++T++++G+ lLr+w+l+P +dl+ I++R+da+++++  ++++ +e+re+l+ +++++R+++r+   ka+++d ++l+++l   +++ +
  EFC36581.1 333 KEGlSLFGIMNKTKSSVGKDLLRQWFLKPVMDLDIIKKRHDAIDYFSrfSDDIIDEIRENLKFVKNTKRIINRMREAKATVNDWSNLYKTLYCYKNITE 431
                 3446****************************************864444555777778899999******************9999999998888888 PP

                 T---SSTHHHHH..........HH.HH..HHHHHHB-SS--SSGGGS--B-T............................................... CS
                 xxxxxxxxxxxx..........xx.xx..xxxxxxxxxxxxxxxxxxxxxxx............................................... RF
    MutS_III 113 llekeklaesee..........es.la..elleeaideeplalekegedlra............................................... 151
                 +l++ + ++s e          es ++  + +++ +d ++++++++  +++                                                
  EFC36581.1 432 ILSEMDDNPSVEvaqdllnhdnESiMKvlQAISKIVDLKESRSQNRLVIMTGvnseldnrrqtyesldtfldlvaqqesnsfpedfpfsfkavyypqlg 530
                 8877766655557777777766332225589999999999999999999999*********************************************** PP

                 ....................................................HHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHH CS
                 ....................................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    MutS_III 152 ....................................................iealeqelfqelleeveealerlrrlaealaeLDvllSlA 191
                                                                     i + e+++  +l + v ++ +++++  +++a LD+++S+A
  EFC36581.1 531 fllvvdknetsenyseyaqyglrfhfssdrslyfkndttdeldtevgdihhlIIEQETSISVKLEKYVLQYHDQINKSNDLCAKLDCIISMA 622
                 ***************************************************9999999999*****************************98 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.93
                 T.........................................................................HHHHHHHHHHHHHHH CS
                 x.........................................................................xxxxxxxxxxxxxxx RF
    MutS_III 151 a.........................................................................iealeqelfqellee 166
                                                                                           +++++ +lf el ++
  EFC36581.1 815 LidsvnelpndmedehfvvpsaedlvflykltrgkiipsygitvaslaglpnqiierakfvaerlskskpieavKDNEKGKLFYELYDR 903
                 02222222222222223444444444444444444444444444444444444444444444444444444444444444455555555 PP

>> MutS_IV  MutS family domain IV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.1   4.4e-08   0.00013       1      90 [.     483     580 ..     483     582 .. 0.91

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 4.4e-08
                 TTSHHHHHHHHHHHHHHHHHHHHHCCCCC....CCT-TTBEECCCSSSEEEEEE-TCCCTTT--SEEE..EEECTCEEE...EECCCHHHHHHHHHHHH CS
     MutS_IV   1 gfdeeLdelrdrleelekeleeleekere....klgikslkveynkvlGyylevtrseakkvpkefir..lqtlknser...yttaelkkleaelleae 90 
                 g+++eLd+ r+++e l ++l+ ++++e++    ++   s+k  y ++lG++l v ++e+++  +e+ +  l + ++s r   + ++++ +l+ e+++++
  EFC36581.1 483 GVNSELDNRRQTYESLDTFLDLVAQQESNsfpeDFPF-SFKAVYYPQLGFLLVVDKNETSENYSEYAQygLRFHFSSDRslyFKNDTTDELDTEVGDIH 580
                 789*************************955545555.************************99999988888999998999*************9987 PP

>> MutS_II  MutS domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   3.9e-05      0.12      12      94 ..     121     209 ..     112     221 .. 0.78
   2 ?   -2.7   0.0       2.3   6.8e+03     107     127 ..     264     284 ..     249     295 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.9e-05
                 TSEEEEEEEETTTTEEEEEEEEE...-HHHHHHHHHH-ESEEEEESS-SCCCH...HHHHHCHCTTT-EEEEESCCCCSHCCHHHHCHH CS
     MutS_II  12 grrvGlafiDlstgefvvsefed...feeleaeLsrlsPkElllpedlsesta...eeessklrelrsrvgvretvefesekaserlee 94 
                   r G+a  D+++ge+   e+++   fe  e     ++P  +l+p+ l++s +   ++ ++  +e+   v+  ++ +f+ e+a++++++
  EFC36581.1 121 RGRLGVAAFDMNSGELLCGETNEntlFEATEFVKFEVKPNLILVPSRLEQSFMkhvKKPIEGAKEQQIEVKLLKSSDFSAENATKKIQL 209
                 3448******************966555544444459***********88866777777777788888888889999999999999875 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.3
                 GGG-HHHHHHHHHHHHHCCCC CS
     MutS_II 107 ekekklalaAlgalisYleet 127
                  +e+   ++Alg l+ +++  
  EFC36581.1 264 VEENTQTVRALGGLLCHIQTN 284
                 378888999999999998765 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   1.1    0.0026       7.6      95     212 ..     350     469 ..     331     521 .. 0.83
   2 ?    5.6   0.0    0.0041        12       3      13 ..     671     681 ..     669     721 .. 0.94
   3 ?    1.6   0.1     0.066     2e+02     254     302 ..     744     795 ..     737     796 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0026
      AAA_21  95 esgllldkrsleeedvfnpeargirggvsvfslkelsvsepndlqfgkaltditsrawsllllldglrke..rigllnifadyfgfakekrllqrlvrs 191
                 ++ ll++   ++ +d ++ ++r+  ++++++ +  ++ ++ ++l+f+k++ +i++r ++++   +++ +   +  ++ +  + + +++ ++ ++   + 
  EFC36581.1 350 GKDLLRQWFLKPVMDLDIIKKRHDAIDYFSRFSDDIIDEIRENLKFVKNTKRIINRMREAKATVNDWSNLykTLYCYKNITEILSEMDDNPSVEVAQDL 448
                 667777777888888899999***************************************************999999999999999999999877777 PP

      AAA_21 192 lklveielsdlgegeeliasv 212
                 l+ ++  +++ + ++ +i + 
  EFC36581.1 449 LNHDNESIMKVLQAISKIVDL 469
                 777777776666555555444 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0041
      AAA_21   3 vliGpNgsGKS 13 
                 +++GpN+sGKS
  EFC36581.1 671 IITGPNNSGKS 681
                 79********9 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.066
      AAA_21 254 alkkgsllliDEpEng.LHP...kllrrllell.kelsrngaQviltTHSplll 302
                  ++++sllliDE+  g L     +ll+ +l+ + ++++     vi+tTH  ++l
  EFC36581.1 744 FASSRSLLLIDEFGKGtLALdgiALLSAILKHFqEREH--VPRVIVTTHYVEVL 795
                 566779*******9999999777777777777753333..37999999986665 PP

>> AF0941-like  AF0941-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0       0.2     6e+02      49      84 ..     284     319 ..     249     331 .. 0.85
   2 ?    7.3   2.8    0.0022       6.6      15     110 ..     368     474 ..     357     477 .. 0.73

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.2
                  HHHHTTSS-HHHHHHHHHHHHHHHHHTHHHHHHHHH CS
  AF0941-like  49 eklkagdieeeeakknlklLkvyvvsqLdehykrvl 84 
                  ++l+ g++++ e+ kn+k +k + +   ++ + +v+
   EFC36581.1 284 NRLSFGELDDIEVLKNIKNIKNFKLFSNQNSHAHVV 319
                  567889***************998866665555554 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0022
                  HT.....TSS-GGGHHHHT-HHHHHHH.HHHHHHHHHHHHHTTSS-HHHHHHHHHHHHHH.....HHHTHHHH..HHHHHHHHHCTT-----..HHHH CS
  AF0941-like  15 lk..keviddiekvldelldkeeieel.frsdvedvleklkagdieeeeakknlklLkvy.....vvsqLdeh..ykrvlelledkekkiek..evvd 100
                  +k  +++id  ++ +d+++d+ +  +l f ++++ +++++++ +++ ++  + +k L  y     ++s +d +   +   +ll++ ++ i k  + + 
   EFC36581.1 368 IKkrHDAIDYFSRFSDDIIDEIRE-NLkFVKNTKRIINRMREAKATVNDWSNLYKTLYCYkniteILSEMDDNpsVEVAQDLLNHDNESIMKvlQAIS 464
                  55557899999999*****97664.445***********************88888988854333455555432144455677777777777777777 PP

                  HHHHHHHHHH CS
  AF0941-like 101 eIveaierae 110
                  +Iv+ +e+ +
   EFC36581.1 465 KIVDLKESRS 474
                  8887777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (924 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       809  (0.0451224); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.80u 0.31s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 5325.52
//
Query:       EFC36582.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.5e-13   48.6   4.2    6.1e-07   29.9   0.4    1.5  2  Ank_2     Ankyrin repeats (3 copies)
    1.7e-07   31.3   0.0    3.9e-07   30.2   0.0    1.7  1  Ank_5     Ankyrin repeats (many copies)
    7.8e-06   26.3   0.1     0.0014   19.2   0.0    2.6  3  Ank_4     Ankyrin repeats (many copies)
    4.4e-05   23.5   0.2      0.003   17.9   0.0    2.7  3  Ank_3     Ankyrin repeat
    0.00016   21.9   0.0    0.00051   20.4   0.0    1.9  2  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.2   1.3e-09   4.6e-06      29      83 .]     114     179 ..      93     179 .. 0.70
   2 !   29.9   0.4   1.7e-10   6.1e-07       5      74 ..     119     203 ..     115     213 .. 0.76

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 1.3e-09
       Ank_2  29 aLhyAakngnleivklLleh......ad.....ndgrtpLhyAarsghleivklLlekgadinlkd 83 
                  L+  a  gnl ++k  le+      ++      d +tpLh A+ +++leiv+ Ll++gad++++d
  EFC36582.1 114 SLFEHAVDGNLTALKKCLENtnnshdINeklqfGDEWTPLHGAVVYNQLEIVEHLLKHGADYTITD 179
                 555334445566666666643333342233435569********************99*****997 PP

  == domain 2  score: 29.9 bits;  conditional E-value: 1.7e-10
       Ank_2   5 akngnlelvklLl....egadpn.k....ngktaLhyAakngnleivklLleh......adndgrtpLhyAarsghleivklLle 74 
                 a +gnl ++k  l    +++d+n k    +++t+Lh A+ +++leiv+ Ll+h      +d+ gr+ L +A   + +++v +L +
  EFC36582.1 119 AVDGNLTALKKCLentnNSHDINeKlqfgDEWTPLHGAVVYNQLEIVEHLLKHgadytiTDKRGRSCLTLARILNFTQCVTMLKK 203
                 5566677888888655455777773567888999999999999999999999996666666889999999999999999999964 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.2   0.0   1.1e-10   3.9e-07      13      56 .]     148     189 ..     131     189 .. 0.85

  Alignments for each domain:
  == domain 1  score: 30.2 bits;  conditional E-value: 1.1e-10
       Ank_5  13 dgggntpLhvAakygaadvvrlLlargadlnltdsrGltaldlA 56 
                 d++  tpLh A+ y+ +++v+ Ll++gad+++td+rG++ l lA
  EFC36582.1 148 DEW--TPLHGAVVYNQLEIVEHLLKHGADYTITDKRGRSCLTLA 189
                 333..********************************9988776 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.7   1.3e+04      16      33 ..      85     102 ..      81     105 .. 0.61
   2 !   12.3   0.0   5.6e-05       0.2       4      51 ..     114     165 ..     112     166 .. 0.82
   3 !   19.2   0.0   3.8e-07    0.0014       2      54 ..     150     201 ..     149     201 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.7
       Ank_4  16 lvrlLl.ekgadinaqdnr 33 
                 +v+l + ++g d+    ++
  EFC36582.1  85 NVDLSFaSHGTDVSDI-SE 102
                 5667773468887664.44 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 5.6e-05
       Ank_4   4 aLhyaaisgrlelvrlLl...ekgadinaq.dnrsGetalhiAakrgnveil 51 
                  L+  a +g+l +++ +l   ++  din+    ++ +t+lh A+  +++ei+
  EFC36582.1 114 SLFEHAVDGNLTALKKCLentNNSHDINEKlQFGDEWTPLHGAVVYNQLEIV 165
                 4899999***********55556788****667********99877777766 PP

  == domain 3  score: 19.2 bits;  conditional E-value: 3.8e-07
       Ank_4   2 ltaLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklL 54 
                 +t+Lh a+ +++le+v+ Ll +gad   + +++G+++l  A   ++ +++ +L
  EFC36582.1 150 WTPLHGAVVYNQLEIVEHLLKHGADYTIT-DKRGRSCLTLARILNFTQCVTML 201
                 79***********************9999.*********99555567777776 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.063   2.3e+02       5      28 ..     114     139 ..     111     142 .. 0.71
   2 !   17.9   0.0   8.5e-07     0.003       2      29 ..     149     175 ..     148     177 .. 0.92
   3 ?   -3.1   0.0         5   1.8e+04       2      15 ..     182     195 ..     181     203 .. 0.64

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.063
       Ank_3   5 pLhlAarsgnleivkfLle..nkgad 28 
                  L++ a  gnl+ +k +le  n+  d
  EFC36582.1 114 SLFEHAVDGNLTALKKCLEntNNSHD 139
                 4677777788888******5555555 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 8.5e-07
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                  +tpLh A+ ++ leiv+ Ll+ +gad 
  EFC36582.1 149 EWTPLHGAVVYNQLEIVEHLLK-HGADY 175
                 69********************.9**97 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 5
       Ank_3   2 GetpLhlAarsgnl 15 
                 G++ L lA   + +
  EFC36582.1 182 GRSCLTLARILNFT 195
                 78888777655555 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   1.4e-07   0.00051       1      31 [.     148     179 ..     148     180 .. 0.92
   2 ?   -2.7   0.0       2.9     1e+04       2      20 ..     182     200 ..     181     204 .. 0.60

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.4e-07
                 TSBBHHHHHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   1 dGnTPLHlAatngkkriiklLL.hGAnlnald 31 
                 d +TPLH A+ +++++i++ LL hGA+ +++d
  EFC36582.1 148 DEWTPLHGAVVYNQLEIVEHLLkHGADYTITD 179
                 789****99999***************99888 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.9
                 SBBHHHHHHHHTTHHHHHH CS
         Ank   2 GnTPLHlAatngkkriikl 20 
                 G+++L lA   + ++++ +
  EFC36582.1 182 GRSCLTLARILNFTQCVTM 200
                 7777777643333556665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       835  (0.0465726); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1512.91
//
Query:       EFC36583.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00044   20.1   0.6        1.6    9.0   0.1    3.9  4  TPR_2     Tetratricopeptide repeat
    0.00048   19.6   4.1     0.0011   18.4   3.3    2.0  2  SNAP      Soluble NSF attachment protein, SNAP
     0.0016   18.2   0.4          1    9.3   0.1    3.8  4  TPR_1     Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.01   15.6   1.7      0.022   14.5   1.7    1.5  1  DUF2225   Uncharacterized protein conserved in bacteria (DUF2
      0.012   15.8   1.5         39    4.8   0.1    4.0  4  TPR_8     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.1   0.00045       1.6      18      33 ..     104     119 ..      95     120 .. 0.79
   2 ?    3.9   0.0     0.019        69       2      27 ..     128     153 ..     127     154 .. 0.89
   3 ?   -3.0   0.0       3.2   1.2e+04      14      26 ..     191     203 ..     189     208 .. 0.71
   4 ?    2.7   0.0     0.046   1.7e+02      10      26 ..     264     280 ..     263     283 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00045
       TPR_2  18 eeAleafekAleldPn 33 
                  eA++af++A+e++  
  EFC36583.1 104 SEAIDAFREAIEIYDS 119
                 7***********9976 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.019
       TPR_2   2 ealynlGlayyklgdyeeAleafekA 27 
                  ++++ + ++  lg+y e  +++ k+
  EFC36583.1 128 SLCFEVAHVLKVLGKYSESSHFYSKC 153
                 578999*************9999986 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 3.2
       TPR_2  14 lgdyeeAleafek 26 
                 l+ ++ A++++ +
  EFC36583.1 191 LNALQNAIDCLLE 203
                 5566778888765 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.046
       TPR_2  10 ayyklgdyeeAleafek 26 
                 +++ +++ eeA e fe 
  EFC36583.1 264 VLLLQKRKEEATEVFET 280
                 6889***********96 PP

>> SNAP  Soluble NSF attachment protein, SNAP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   3.3   3.1e-07    0.0011      72     180 ..      45     152 ..       2     164 .. 0.82
   2 ?   -1.3   0.0      0.32   1.2e+03      88     116 ..     185     213 ..     159     230 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.1e-07
                 HHHHHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHTT- CS
        SNAP  72 deaanayveAakcykkvspeeAvealekAieiytekgrfrraAklkkeiaelyekelgdlekAieaYekAaelyeqeeakalankcllkvAelsaelek 170
                 + +++ +  A +++   ++e+  ++  +A+ +y+ +gr+      ++++ + +  e + +++Ai+a+++A e+y+++++ +   ++  +vA++   l+k
  EFC36583.1  45 QRTGQKHYTAVSMLCAANAEKLNKTPLNAAFFYVYSGRIFSDQACSENLIQYFTAE-EFISEAIDAFREAIEIYDSNGVYSMCASLCFEVAHVLKVLGK 142
                 45677777788888888888888888889999999999988888999999999999.999999999999999999999999999999999999999999 PP

                 HHHHHHHHHH CS
        SNAP 171 yekAieiyek 180
                 y+++ + y+k
  EFC36583.1 143 YSESSHFYSK 152
                 9999999987 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.32
                 T-HHHHHHHHHHHHHHHHHTT-HHHHHHH CS
        SNAP  88 vspeeAvealekAieiytekgrfrraAkl 116
                 +s +   +al++Ai++++e   f++a  +
  EFC36583.1 185 TSHSMELNALQNAIDCLLEIKDFEMAVLR 213
                 55556678999999999999999998655 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.1   0.00028         1      18      33 ..     104     119 ..     103     120 .. 0.87
   2 ?    3.6   0.0     0.018        63       6      27 ..     132     153 ..     127     153 .. 0.84
   3 ?   -0.5   0.0      0.36   1.3e+03      16      24 ..     193     201 ..     189     211 .. 0.56
   4 ?   -0.8   0.0      0.43   1.5e+03      10      25 ..     264     279 ..     263     280 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00028
                 HHHHHHHHHHHHHSTT CS
       TPR_1  18 deAleyyekALelnPn 33 
                  eA++++++A+e++ +
  EFC36583.1 104 SEAIDAFREAIEIYDS 119
                 59**********9866 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.018
                 HHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyyekA 27 
                   ++++  lgky e   +y+k+
  EFC36583.1 132 EVAHVLKVLGKYSESSHFYSKC 153
                 56899999***********996 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.36
                 -HHHHHHHH CS
       TPR_1  16 kydeAleyy 24 
                  ++ A+++ 
  EFC36583.1 193 ALQNAIDCL 201
                 555566654 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 0.43
                 HHHHTT-HHHHHHHHH CS
       TPR_1  10 ayfklgkydeAleyye 25 
                 +++ +++ +eA e +e
  EFC36583.1 264 VLLLQKRKEEATEVFE 279
                 6789*******98776 PP

>> DUF2225  Uncharacterized protein conserved in bacteria (DUF2225)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   1.7   6.1e-06     0.022      61     192 ..      11     154 ..       8     177 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6.1e-06
     DUF2225  61 kdfeklskeekeklkekiskkwksrdfsk.ertldeaiesYkLallcyelkkekkskkAklalrlAWlyrdked.............eekeklflkkAl 145
                 ++f+k+ ++ k+k+ +ki     s ++++ +  l++  ++++ a+   ++ +++k    k+ l++A +y  ++                  ++f+ +A+
  EFC36583.1  11 EEFKKIADRLKKKMFRKIPYDQISEQYANfSLHLQRTGQKHYTAVSMLCAANAEKL--NKTPLNAAFFYVYSGRifsdqacsenliqYFTAEEFISEAI 107
                 6899*************999999999999899999999999988765444443333..33445555555555555555555888997677899****** PP

     DUF2225 146 elykeayekesfpvegideatvlYLiaeLerrlgnkeealrwlskvi 192
                 + ++ea+e  +++      a++ + +a   + lg++ e+  ++sk +
  EFC36583.1 108 DAFREAIEIYDSNGVYSMCASLCFEVAHVLKVLGKYSESSHFYSKCY 154
                 ************999999999*****************999999975 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1     0.012        42      19      31 ..     105     117 ..     103     120 .. 0.86
   2 ?    4.8   0.1     0.011        39       1      27 [.     127     153 ..     127     154 .. 0.92
   3 ?   -1.8   0.0       1.5   5.3e+03      18      26 ..     195     203 ..     189     211 .. 0.54
   4 ?    2.3   0.0     0.069   2.5e+02       7      26 ..     261     280 ..     257     283 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.012
                 HHHHHHHHHHHHH CS
       TPR_8  19 eAkeyyekaleld 31 
                 eA+ ++++a+e+ 
  EFC36583.1 105 EAIDAFREAIEIY 117
                 9**********97 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.011
                 CCHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   1 aeayynlgsiylklgdyeeAkeyyeka 27 
                 a++++  +++++ lg+y e+  +y k+
  EFC36583.1 127 ASLCFEVAHVLKVLGKYSESSHFYSKC 153
                 5789999******************99 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.5
                 HHHHHHHHH CS
       TPR_8  18 eeAkeyyek 26 
                 ++A+ ++ +
  EFC36583.1 195 QNAIDCLLE 203
                 555555543 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.069
                 HHHHHHHTT-HHHHHHHHHH CS
       TPR_8   7 lgsiylklgdyeeAkeyyek 26 
                 l +++l ++++eeA e++e 
  EFC36583.1 261 LLLVLLLQKRKEEATEVFET 280
                 56778889**********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       904  (0.0504211); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 2190.54
//
Query:       EFC36584.1  [L=147]
Description: vacuolar protein sorting 55 superfamily protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-31  108.4   7.7    2.3e-31  108.2   7.7    1.1  1  Vps55            Vacuolar protein sorting 55
  ------ inclusion threshold ------
      0.018   13.6   6.2      0.026   13.1   5.6    1.5  1  MFS_2            MFS/sugar transport protein
        9.3    6.2   6.3          5    7.1   1.2    2.2  2  RseC_MucC        Positive regulator of sigma(E), RseC/MucC


Domain annotation for each model (and alignments):
>> Vps55  Vacuolar protein sorting 55
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.2   7.7   3.9e-35   2.3e-31       1     114 [.      11     134 ..      11     137 .. 0.94

  Alignments for each domain:
  == domain 1  score: 108.2 bits;  conditional E-value: 3.9e-35
       Vps55   1 iillsfvlaiGfllvilsCal.......yknwwpLlvvlfyllaplPnliakrlsssed..s.eessalkdlakFltgvlvvsgiaLpivLahagiikw 89 
                 ++++++ ++iG++l i++Ca+       ++nw++L++vl+y++ap+P +ia+++ss+ +  + e+ ++++++++Flt+++++ g++L +vLah+gii+w
  EFC36584.1  11 LVAVAAGVSIGVMLAIIGCAVtwggvehPENWFALITVLCYIIAPFPDIIARAFSSRFEkeDpEDATVWEHFGAFLTSFIATIGLGLLFVLAHTGIIQW 109
                 6899*********************998889************************99864426889********************************* PP

       Vps55  90 galilslaggvviyltiivfflffk 114
                 ++++++++gg+vi++t+++ fl+f+
  EFC36584.1 110 ETFAFEISGGIVIVATLFISFLVFT 134
                 *********************9997 PP

>> MFS_2  MFS/sugar transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   5.6   4.4e-06     0.026      73     196 ..      15     136 ..       9     146 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 4.4e-06
       MFS_2  73 lsaiilavsiillftppelsqs.akfiwllvtyillrilytlfeipyvslvpvltkdydeRtsltsvrsflsvlggvlaailafllvlilgglkserkg 170
                 ++++ ++v+++ +  + +++ + +   w++++ +l+ i   + +i   +  +    ++++ +++t++ +f + l++++a+i  +ll++   + +  +  
  EFC36584.1  15 AAGVSIGVMLAIIGCAVTWGGVeHPENWFALITVLCYIIAPFPDIIARAFSSRF--EKEDPEDATVWEHFGAFLTSFIATIGLGLLFVLAHT-GIIQWE 110
                 455566666666666666666699999*******************99999999..999***************************999998.999999 PP

       MFS_2 171 ylifaliialLmllgviivvlgtker 196
                 +++f + + ++++++ +i++l++   
  EFC36584.1 111 TFAFEISGGIVIVATLFISFLVFTIA 136
                 99999999999999999999877543 PP

>> RseC_MucC  Positive regulator of sigma(E), RseC/MucC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.3      0.03   1.8e+02      79     119 ..      24      69 ..       3      80 .. 0.51
   2 ?    7.1   1.2   0.00084         5      64     122 ..      86     143 ..      80     147 .] 0.79

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.03
   RseC_MucC  79 ilgallgsall............gssellaalgallglvlgf..livrllskrlk 119
                 +         +            + ++++a+++ l+ +++ f  +i+r +s+r++
  EFC36584.1  24 L---------AiigcavtwggveHPENWFALITVLCYIIAPFpdIIARAFSSRFE 69 
                 1.........122222223344344445555555554444444445566665555 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.00084
   RseC_MucC  64 lkaallvYllPllllilgallgsallgssellaalgallglvlgflivrllskrlkkks 122
                 l++ +   +l ll++++ + ++++ +++ e+   ++ ++ l+++fl+ ++ ++r ++ +
  EFC36584.1  86 LTSFIATIGLGLLFVLAHTGIIQWETFAFEISGGIVIVATLFISFLVFTIAKRR-EDAE 143
                 555566667778999999999999999999999999999999999999988888.4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (147 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       912  (0.0508673); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.33s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 858.99
//
Query:       EFC36585.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.1e-07   29.4   0.3    9.5e-07   28.5   0.3    1.5  1  F-box       F-box domain
    5.2e-05   23.0   0.0    0.00011   22.0   0.0    1.6  1  F-box-like  F-box-like
    0.00034   20.5   0.1    0.00047   20.0   0.1    1.3  1  F-box_4     F-box
  ------ inclusion threshold ------
      0.041   13.3   0.0      0.059   12.8   0.0    1.2  1  ShlB        Haemolysin secretion/activation protein ShlB/FhaC
      0.065   12.8   0.1       0.12   12.0   0.1    1.4  1  F-box_5     F-box


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5   0.3   2.7e-10   9.5e-07       4      34 ..      40      70 ..      37      79 .. 0.92

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 2.7e-10
                HHS-HHHHHHHHHTS-HHHHHHHCTT-HHHH CS
       F-box  4 srLPsevlrhILerLplsdllalrrVSkgwr 34
                 +LP+evl+++L +L++++l +lr  +k++ 
  EFC36585.1 40 AQLPDEVLEQVLFFLDHKSLMRLRVSCKSFS 70
                68***************************96 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0     3e-08   0.00011       2      32 ..      40      70 ..      39      78 .. 0.92

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 3e-08
  F-box-like  2 srLPdEiLlqIFsyLppsdLlrlalVCrrWr 32
                ++LPdE+L q++ +L+ ++L rl+  C+++ 
  EFC36585.1 40 AQLPDEVLEQVLFFLDHKSLMRLRVSCKSFS 70
                68**************************986 PP

>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.1   1.3e-07   0.00047       4      37 ..      38      71 ..      35     108 .. 0.82

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1.3e-07
     F-box_4  4 sLssLPlevlqhiaslLDsfsLsqLslvskllre 37
                s+ +LP evl++++ +LD  sL++L   +k++ e
  EFC36585.1 38 SVAQLPDEVLEQVLFFLDHKSLMRLRVSCKSFSE 71
                6789*********************999998765 PP

>> ShlB  Haemolysin secretion/activation protein ShlB/FhaC/HecB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   1.7e-05     0.059     230     262 ..      91     123 ..      88     125 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.7e-05
                 -SS-SSCCCSEEESSTTSSTT--TT-EEESEEE CS
        ShlB 230 skdaLysseqlsiGgrytVRGFdeqslsgdsGf 262
                 ++d Ly  e l+i ++ +V GF+ + ls d+G+
  EFC36585.1  91 NQDDLYHYESLQISDMANVIGFHVSVLSHDQGW 123
                 689*****************************9 PP

>> F-box_5  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   3.3e-05      0.12       3      18 ..      41      56 ..      39      58 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3.3e-05
                --GGGTHHHHHCC--- CS
     F-box_5  3 gfpDeVlecVlpyits 18
                ++pDeVle+Vl +++ 
  EFC36585.1 41 QLPDEVLEQVLFFLDH 56
                78***********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       560  (0.0312343); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.48
# Mc/sec: 800.37
//
Query:       EFC36586.1  [L=620]
Description: rasGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-27   95.5   5.4    3.6e-26   92.4   2.7    2.4  2  RasGEF    RasGEF domain
    0.00021   21.5   1.5    0.00085   19.5   1.5    2.1  1  RasGEF_N  RasGEF N-terminal motif


Domain annotation for each model (and alignments):
>> RasGEF  RasGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0      0.01        94      65     147 ..     260     358 ..     202     372 .. 0.67
   2 !   92.4   2.7   4.1e-30   3.6e-26       1     176 [.     375     556 ..     375     557 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.01
      RasGEF  65 kviekfikiakecrklnNfnslmailsaLqsspvsrL..kktweavskkslktle......eleelmspennfknyrealkssa............... 140
                  ++ ++ +i kec++l+ f sl   +  L   + +    ++t  ++++             +le++    n+ ++y ++l++++               
  EFC36586.1 260 AMFDFLHHITKECFELKGFKSLTDSCISLIDLAQQYQkdSETEFEINRIF----VeiidsfRLEQVQ---NENEEYHSELRDKRletpvdlmndhrkfa 351
                 57788899999**********99887777643333330033333333222....2333355555543...33344445555554555566666666666 PP

      RasGEF 141 sskpciP 147
                 ++kp+iP
  EFC36586.1 352 APKPIIP 358
                 7777777 PP

  == domain 2  score: 92.4 bits;  conditional E-value: 4.1e-30
      RasGEF   1 elAeqltlieaelfskikpeellgsawskedrs....pnveavia..rfnrls.nwvaseilseeslkkRakviekfikiakecrklnNfnslmailsa 92 
                 e+A+ql l ++++f++i+p e+++  w ++d++    + ++a+i+  ++ +l+  +++ +ils+ ++k+R ++++k+i++  e+++lnNf ++  +l a
  EFC36586.1 375 EIARQLSLRDYDYFKEIDPNEYFE--WIRHDNNhsgrSACKAIIEmkMIGSLTiSMLVFSILSQVNIKERKELLCKVIDLSLELFNLNNFFGVDYVLQA 471
                 79**********************..8888844345433555444113334434888899*************************************** PP

      RasGEF  93 LqsspvsrLkktweavskkslktleeleelmspennfknyrealkssasskpciPflglyltdltfieegnpdtl....egk.iNfeKr 176
                 Lq+s+v+rL++tw+++++k+++++e+l+   + e++++++  +l++   ++  iP++  + +d+  ++e++++ +     ++ i+++K+
  EFC36586.1 472 LQHSSVKRLEHTWKEIDRKKIQQYEKLCY--DMEHDYRKITIQLARN--NAILIPVFMEHFKDIRSVDEAFENVIqdeqGNQlIHWKKV 556
                 *****************999999998886..7788899999999998..7888****************98777777776666***996 PP

>> RasGEF_N  RasGEF N-terminal motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   1.5   9.5e-08   0.00085      20      94 ..     148     259 ..     128     270 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 9.5e-08
    RasGEF_N  20 l...........dddfletFLltyrsFttpaeLlekLierye.................inppnnlesdesnswnsksssn........irl.rvlsvl 81 
                 +           ++ f+et L ty +Fttp+ Ll+k +e+                    ++++  ++d   ++n+k ++          ++  +l+++
  EFC36586.1 148 FlplfpqsvqnrKERFIETILFTYPIFTTPQVLLKKCFETLSniplqflefpimyedidAECEDIWKNDYGFQINEKYTYWrycnslyeYKIfSILEFI 246
                 345555555555789************************998777777777776666552333332333224455555555677666667777999999 PP

    RasGEF_N  82 kewvenhyydfsd 94 
                  +w++  ++d+++
  EFC36586.1 247 IKWIKFRIDDWNS 259
                 9999988888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (620 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       830  (0.0462937); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 3485.83
//
Query:       EFC36587.1  [L=415]
Description: hypothetical protein NAEGRDRAFT_59966 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (415 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1690  (0.0942607); expected 358.6 (0.02)
Passed bias filter:                      665  (0.0370907); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2433.08
//
Query:       EFC36588.1  [L=962]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.4e-49  166.2   0.5    4.8e-48  163.7   0.5    2.1  1  Pkinase_Tyr      Protein tyrosine kinase
    2.2e-46  158.3   0.6      5e-46  157.2   0.6    1.6  1  Pkinase          Protein kinase domain
     0.0081   16.0   0.5       0.04   13.7   0.5    2.2  1  ECSCR            Endothelial cell-specific chemotaxis regulat
  ------ inclusion threshold ------
      0.042   12.6   0.0      0.069   11.9   0.0    1.2  1  Pkinase_fungal   Fungal protein kinase
      0.046   13.5   0.1        0.1   12.4   0.1    1.6  1  LapA_dom         Lipopolysaccharide assembly protein A domain
      0.078   12.8   0.3       0.19   11.5   0.3    1.6  1  Vpu              Vpu protein
       0.13   11.8   2.0       0.25   10.9   2.0    1.4  1  DUF5385          Family of unknown function (DUF5385)
       0.14   12.1   0.0       0.38   10.7   0.0    1.6  1  GRIM-19          GRIM-19 protein
        1.1    8.9   3.7        0.4   10.4   0.1    2.2  3  CTP_transf_1     Cytidylyltransferase family
        1.9    9.1  15.4       0.44   11.1   1.2    5.0  4  Chlam_PMP        Chlamydia polymorphic membrane protein (Chla
          8    6.5   8.8       0.92    9.5   3.6    2.1  2  TMEMspv1-c74-12  Plectrovirus spv1-c74 ORF 12 transmembrane p


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  163.7   0.5   2.9e-51   4.8e-48       3     259 .]     667     953 ..     665     953 .. 0.86

  Alignments for each domain:
  == domain 1  score: 163.7 bits;  conditional E-value: 2.9e-51
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CTT CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..eke 98 
                  + +k+GeG+ G V++++++      +++Va+K+lk   +e + ee+ +ea +m++l+hp +v+++gv + +++ ++v+ey+++G+L+k L k+   ke
   EFC36588.1 667 ILSKIGEGSNGLVYKAKWN------RTDVAIKQLKTLGEE-DDEEFEREALLMSSLRHPSVVSCYGVSITNDSKYMVVEYLENGSLEKALYKSkiGKE 757
                  6789***************......9********765555.59***********************************************99966799 PP

                  TSBHHHHHHHHHHHHHHHHHHHH...TTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHH CS
  Pkinase_Tyr  99 kltlkdllsfalqvAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGv 193
                  kl+++++l++ l+v kGm yL+s   +k++Hrdl   N+Ll++n  +k+sDfGL++ +  ++++ + +++   + ++ + s  +k  t+k Dv+sfG 
   EFC36588.1 758 KLSFETKLNILLDVGKGMTYLHSirpNKIIHRDLKPGNILLTKNLNAKVSDFGLSKMV--SNNTATMTTNVGTLLYIELLSNYHKGQTTKLDVYSFGL 853
                  **********************944456******************************..344444444555566665555566669*********** PP

                  HHHHHHTTSSGT...................................TTTSHHHH.HHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHH CS
  Pkinase_Tyr 194 llwEiftlgesp...................................ypglknee.vleklkegkrlekpekcpeelyelmkkcweedpeeRptfsel 255
                  ++wE++     p                                   ++++ + + +++ +++    ++ ekc ++  e+mk cw ++p++Rp+f e+
   EFC36588.1 854 IMWEVLF-EMVPfsnelsdattpfsillqvtnglrpslsvmgehfeyIQEWIEDHfTMREIQK-IGKQTIEKCLKDYIEVMKLCWYKEPSNRPEFIEI 949
                  ****987.45556799999************************99986666555504555544.44566778*************************9 PP

                  HHHH CS
  Pkinase_Tyr 256 vekl 259
                  +e l
   EFC36588.1 950 TESL 953
                  9876 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  157.2   0.6   3.1e-49     5e-46       3     259 ..     667     950 ..     665     954 .. 0.81

  Alignments for each domain:
  == domain 1  score: 157.2 bits;  conditional E-value: 3.1e-49
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HH... CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslsee... 98 
                  l+k+GeGs+G Vyka+  +++  vA+K++k+  +++++e  + rE  ++ +l+hp +v +y+v  ++d+ y+v+ey+e+g+l+++l ++++ +e+   
  EFC36588.1 667 ILSKIGEGSNGLVYKAK--WNRTDVAIKQLKTLGEEDDEE--FEREALLMSSLRHPSVVSCYGVSITNDSKYMVVEYLENGSLEKALYKSKIGKEKlsf 761
                 5789************9..9999*********99998776..********************************************9854444444455 PP

                 .HHHHHHHHHHHHHHHHHH...TTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHHHH CS
     Pkinase  99 .eakkiakqilegleylHs...kgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvl..keneyskkvDvWslGvilyel 190
                  +  +i+  + +g+ ylHs   ++iiHrDlKp NiL+ ++ + K++DFGl+k +++++  +t+ vgt  Y+  E+l   +++ ++k Dv+s G+i++e+
  EFC36588.1 762 eTKLNILLDVGKGMTYLHSirpNKIIHRDLKPGNILLTKNLNAKVSDFGLSKMVSNNTAtMTTNVGTLLYI--ELLsnYHKGQTTKLDVYSFGLIMWEV 858
                 15559*************833356******************************999988**********9..9**6555777**************** PP

                 HHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS........................-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 191 ltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasei........................seeakdllkkllkkdpkkRltaeell 259
                 l++  pfs+e ++ ++   +  l ++++ l+   ++  ++ + i                         ++ ++++k ++ k+p++R+ + e+ 
  EFC36588.1 859 LFEMVPFSNELSDATTP--FSILLQVTNGLRpSLSVMGEHFEYIqewiedhftmreiqkigkqtiekcLKDYIEVMKLCWYKEPSNRPEFIEIT 950
                 ********655444322..222222222222322233333333355566677788888889999988888999999999999999999877765 PP

>> ECSCR  Endothelial cell-specific chemotaxis regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.5   2.4e-05      0.04      17      85 ..     577     646 ..     573     658 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.4e-05
       ECSCR  17 etvltvaafgvisfivilvvvviilvsvvslrfkcrknkese.dpqkpeisglsescstaigekdsitli 85 
                 e +l  a  g is+i+i+v v+++ + +v    k r++  +e + qk  i   +     ++g   s+ l+
  EFC36588.1 577 EIILPAAIVGAISLIIIFVTVILVGIYIVKKLKKLRRQERAEkEIQKKFIDNSFVFNNGSNGSDLSVPLV 646
                 7789999***************999999987778777666651457765554444444556655566655 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   4.2e-05     0.069     309     387 ..     765     836 ..     737     856 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.2e-05
  Pkinase_fungal 309 lealrDaIkghrsLfl..kagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlk 387
                     l+ l D+ kg   L++    +i+HrD   +Nil+t     ++ +  ++D+ l k +s+  +++   + +GTl +  ie+l+
      EFC36588.1 765 LNILLDVGKGMTYLHSirPNKIIHRDLKPGNILLT-----KNLNAKVSDFGLSKMVSN--NTATMTTNVGTLLY--IELLS 836
                     555666666666665311689**************.....56788899*****99994..66666899999877..55555 PP

>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   6.3e-05       0.1       5      61 ..     568     623 ..     564     625 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.3e-05
    LapA_dom   5 pVtvnflfaqvelpLsllllvafgiGallgwllslwsylrlrrelrrlkkkikklek 61 
                  V   ++  ++ lp +++ +++++i ++ ++l++++ ++++ ++lrr+++  k+ +k
  EFC36588.1 568 NVKCEYIPIEIILPAAIVGAISLIIIFVTVILVGIY-IVKKLKKLRRQERAEKEIQK 623
                 5666677777789**********************5.66777777777666666655 PP

>> Vpu  Vpu protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.3   0.00012      0.19       5      45 ..     583     623 ..     579     641 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00012
         Vpu   5 eliglialivaliiaivvWtivyreykkikkqkeierlikr 45 
                  ++g i li+ ++++i v  +++++ kk ++q++ e+ i++
  EFC36588.1 583 AIVGAISLIIIFVTVILVGIYIVKKLKKLRRQERAEKEIQK 623
                 5789999*************************555544432 PP

>> DUF5385  Family of unknown function (DUF5385)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   2.0   0.00015      0.25       6      42 ..     588     624 ..     585     630 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00015
     DUF5385   6 liiliiiiiiilvivfllrkkkkqkeeekaggkiker 42 
                 + ++ii + +ilv++++++k kk +++e+a+++i+++
  EFC36588.1 588 ISLIIIFVTVILVGIYIVKKLKKLRRQERAEKEIQKK 624
                 568999999*******************999999987 PP

>> GRIM-19  GRIM-19 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00024      0.38      17      61 ..     576     620 ..     571     627 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00024
                 XSXXXXXXXSXSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
     GRIM-19  17 ykrklpktllsglsllalviavtavglyavlksnkerrrekiekr 61 
                 ++  lp  ++ + sl++++++v++vg+y v k +k rr+e+ ek+
  EFC36588.1 576 IEIILPAAIVGAISLIIIFVTVILVGIYIVKKLKKLRRQERAEKE 620
                 5556788899999****************************9986 PP

>> CTP_transf_1  Cytidylyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.1   0.00024       0.4      23     161 ..       5     145 ..       1     160 [. 0.89
   2 ?   -2.4   0.1         2   3.3e+03       9      36 ..     589     604 ..     574     626 .. 0.46
   3 ?   -3.6   0.1       4.6   7.6e+03      61      95 ..     828     862 ..     813     898 .. 0.50

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00024
                   HHHHHHHHHHHHHHHHHHHHTT--SHHHHHHHHH..........HHHHHHHHHHTTTSSSHHHHHHHHHHHHHHHHHH---...HHHHHHHHHHHHH CS
  CTP_transf_1  23 lvflllvavvvilalkElirlvrlkkrekrllll.......llslvlllllllflylesliallklvlllvlvllllvlkvlkskskklervilall 112
                   l f++l+++ +i+++ E+ +++++++re++++++        +++++l  ++  +y+ ++i++++++l l     +l+l+     ++ l+  i+ + 
    EFC36588.1   5 LSFVILLYLFTIVVTGEVKSIQQQQQRESSFTFFldsyqgtETNVSCLDESIPCVYMSQVIDSARSILQLGNNSSTLSLE-----MNILNLSISKCK 96 
                   67999*************************99998988877788999999999999999999999999999999999996.....788888899999 PP

                   HHHHTHHHH.TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH--- CS
  CTP_transf_1 113 allyvvlllqslllienikeglllvllllalvvaaDigaYffGklfGkt 161
                     l +   ++ ++++e+++++l ++  +  lv+++D++ Y+ G l  k+
    EFC36588.1  97 GSLTIQTSIENANILESEFNSLEITSQIQNLVILNDSITYLQGNLKAKQ 145
                   999999999**********************************987665 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2
                   HHHHHHHHTTTSH.HHHHHHHHHHHHHH CS
  CTP_transf_1   9 vlilivliilllgglvflllvavvvila 36 
                    l            +++ + v++v i++
    EFC36588.1 589 SL------------IIIFVTVILVGIYI 604
                   11............12222222222233 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 4.6
                   HHHHHHHHHTTTSSSHHHHHHHHHHHHHHHHHH-- CS
  CTP_transf_1  61 vlllllllflylesliallklvlllvlvllllvlk 95 
                   +ll++ ll +y +  +++l +  + + ++ +l+++
    EFC36588.1 828 TLLYIELLSNYHKGQTTKLDVYSFGLIMWEVLFEM 862
                   33344444444444444444444444444444433 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1       1.6   2.6e+03       2       9 ..     283     290 ..     282     293 .. 0.83
   2 ?    3.3   0.4     0.083   1.3e+02       7      26 ..     344     353 ..     338     354 .. 0.75
   3 ?   11.1   1.2   0.00027      0.44       4      26 ..     367     380 ..     365     382 .. 0.92
   4 ?    0.6   0.1      0.61     1e+03       5      11 ..     816     822 ..     815     844 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.6
   Chlam_PMP   2 itFsnNta 9  
                  +F nN+a
  EFC36588.1 283 SEFFNNQA 290
                 58*****9 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.083
   Chlam_PMP   7 NtatvsstptpaaggGGAIy 26 
                 N+a          g+GGA y
  EFC36588.1 344 NKA----------GYGGAVY 353
                 566..........*****99 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 0.00027
   Chlam_PMP   4 FsnNtatvsstptpaaggGGAIy 26 
                 F+nN a         + +GGAIy
  EFC36588.1 367 FTNNEA---------TQSGGAIY 380
                 9*****.........9******* PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.61
   Chlam_PMP   5 snNtatv 11 
                 snNtat 
  EFC36588.1 816 SNNTATM 822
                 9****54 PP

>> TMEMspv1-c74-12  Plectrovirus spv1-c74 ORF 12 transmembrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.2       2.4     4e+03       7      19 ..       3      15 ..       1      30 [. 0.79
   2 ?    9.5   3.6   0.00056      0.92      10      47 ..     589     626 ..     581     628 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.4
  TMEMspv1-c74-12  7 tiFSvvivLgiFl 19
                     t+ S vi+L +F 
       EFC36588.1  3 TLLSFVILLYLFT 15
                     7889999999986 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00056
  TMEMspv1-c74-12  10 SvvivLgiFlyiGLsiyqKikqirgkkkDKKeierked 47 
                      S++i+    + +G+ i +K k++r++ +  Kei++k +
       EFC36588.1 589 SLIIIFVTVILVGIYIVKKLKKLRRQERAEKEIQKKFI 626
                      778888888889999*******************9965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (962 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1048  (0.0584528); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.89u 0.40s 00:00:01.29 Elapsed: 00:00:00.56
# Mc/sec: 5159.14
//
Query:       EFC36589.1  [L=189]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-40  138.1   0.4    2.6e-40  137.8   0.4    1.1  1  IF4E      Eukaryotic initiation factor 4E


Domain annotation for each model (and alignments):
>> IF4E  Eukaryotic initiation factor 4E
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.8   0.4   1.5e-44   2.6e-40       2     151 ..      11     162 ..      10     170 .. 0.91

  Alignments for each domain:
  == domain 1  score: 137.8 bits;  conditional E-value: 1.5e-44
                 EEEEEEEEEE-TTT.--SS-SGGG-EEEEEEEEHHHHHHHHHHS--GGGB-SSEEEEEEETT--SSTTSHHHHS-EEEEEEE--..---HHHHHHHHHH CS
        IF4E   2 LkskWtlwfdsksk.sksenyeeslkkvatfstveeFwslynnlkkpsklkvksdyhlFkkgikPmWEdpankkGGkwvirlkk..kekldrlWeelll 97 
                 L+++Wtlw++s ++  +++ny++  +kv  f+t+e+Fw+l+nn+++ps l+ +++y+l+k+ ikP WEdp+  +GG++v+++ k  ++++d++W   ++
  EFC36589.1  11 LHNTWTLWYHSPRSkINEQNYKAFFTKVKAFTTIEDFWRLFNNVRSPSCLPIGTTYYLMKDAIKPEWEDPNCINGGEMVFSFAKksRQEADQWWLFSCI 109
                 89*******55555589999**************************************************************5534667********** PP

                 HHHTT-SS--.-SEEEEEEEE-SSEEEEEEEES-TT-HHHHHHHHHHHHHT--- CS
        IF4E  98 aligeqleeeedeicGvvvsvRkkedrisiWtrdasdeekvekigeklkevlel 151
                 ++ige++   +d+icG++v  Rk+  ris W++++ ++e v++++++ k + ++
  EFC36589.1 110 MCIGENFIGLGDHICGCTVANRKSMIRISFWLDTD-EDEYVKRLEDQCKGAFDI 162
                 ***********************************.669999999999876654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       504  (0.0281109); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1183.34
//
Query:       EFC36590.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-43  147.6   0.8    3.4e-43  147.2   0.8    1.1  1  IF4E      Eukaryotic initiation factor 4E
  ------ inclusion threshold ------
       0.14   11.0   2.6       0.22   10.4   2.6    1.3  1  HSP90     Hsp90 protein


Domain annotation for each model (and alignments):
>> IF4E  Eukaryotic initiation factor 4E
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  147.2   0.8   3.8e-47   3.4e-43       2     158 ..      31     188 ..      30     189 .. 0.94

  Alignments for each domain:
  == domain 1  score: 147.2 bits;  conditional E-value: 3.8e-47
                 EEEEEEEEEE-TTT.--SS-SGGG-EEEEEEEEHHHHHHHHHHS--GGGB-SSEEEEEEETT--SSTTSHHHHS-EEEEEEE-----.HHHHHHHHHHH CS
        IF4E   2 LkskWtlwfdsksk.sksenyeeslkkvatfstveeFwslynnlkkpsklkvksdyhlFkkgikPmWEdpankkGGkwvirlkkkek.ldrlWeellla 98 
                 L+++Wtlw+++ +   +++ny++  ++v+tfs+ve+Fws++n+++ ps+++++++y l+k+gikP WEdp+   GG+wv+++ kk++ +d++W +l++ 
  EFC36590.1  31 LENTWTLWYHNPQAkLNEQNYSHFYNEVYTFSDVETFWSVFNHIRGPSEISTGTTYFLLKEGIKPEWEDPKCIGGGEWVYSFPKKHVpADQYWLDLVMF 129
                 89*******55544789999**************************************************************885556*********** PP

                 HHTT-SS--.-SEEEEEEEE-SSEEEEEEEES-TT-HHHHHHHHHHHH.HT--------EE CS
        IF4E  99 ligeqleeeedeicGvvvsvRkkedrisiWtrdasdeekvekigeklk.evlelpeekkle 158
                 ++ge++  + d+  G++v  Rk++ ri++W+++  de   ++ ge++k e+l++  +++++
  EFC36590.1 130 CVGESFTYS-DNLLGCCVANRKNQIRINLWVDTL-DETIAKRFGEQFKfEALKIGANTNIK 188
                 ******888.************************.99***********9999999888775 PP

>> HSP90  Hsp90 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   2.6   2.4e-05      0.22      56     120 ..       8      71 ..       1      82 [. 0.76

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 2.4e-05
                 XXXXXXX..XXXXXXXXXXEEEEEEESXXSXGGGSXGG.GSXHHHHHHHHHHTTTTTSXXSEEEEE CS
       HSP90  56 eeeeeeeeekkktkkvketvkewellNkqkpiWlrkpk.evteeeYkeFYkslskdsedplavkhf 120
                  ++ee   e++++ +v+e+v e   l ++  +W ++p+  ++e++Y++FY+ +   s+ +  ++ f
  EFC36590.1   8 IDQEE--IENDTEAEVNEEVAERPILENTWTLWYHNPQaKLNEQNYSHFYNEVYTFSDVETFWSVF 71 
                 33222..236777889******************998637999********998766666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1310.45
//
Query:       EFC36591.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.6e-11   42.9   0.0    7.1e-11   42.2   0.0    1.3  1  GATase           Glutamine amidotransferase class-I
    6.1e-06   26.1   0.0     0.0049   16.7   0.0    3.2  3  Peptidase_C26    Peptidase C26
    1.9e-05   24.4   0.0    2.6e-05   23.9   0.0    1.2  1  GATase_3         CobB/CobQ-like glutamine amidotransferase do
    0.00037   21.3   0.9      0.014   16.3   0.2    2.3  2  GramPos_pilinBB  Gram-positive pilin backbone subunit 2, Cna-
    0.00088   19.1   0.0     0.0018   18.1   0.0    1.5  1  DJ-1_PfpI        DJ-1/PfpI family
  ------ inclusion threshold ------
      0.012   15.3   0.0       0.02   14.6   0.0    1.3  1  ThiJ_like        ThiJ/PfpI family-like
       0.03   14.2   0.0       0.12   12.3   0.0    2.1  1  SNO              SNO glutamine amidotransferase family


Domain annotation for each model (and alignments):
>> GATase  Glutamine amidotransferase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.2   0.0   2.8e-14   7.1e-11      35     176 ..      51     206 ..      25     216 .. 0.72

  Alignments for each domain:
  == domain 1  score: 42.2 bits;  conditional E-value: 2.8e-14
                 HHHH....THHSTSEEEEEEESSCTT......TTTHHHHHHHHCTSTS-EEEETHHHHHHHHHTTT.....EEEEEECEEEEEEE.EEEEETTT...CG CS
      GATase  35 eile....llknpdgilvsgGpgspg......vegkieaikearenkiPiLGICLGmQllaiefgr.....kvvkekekehhggt.mrlgddet...al 114
                 ++ +    + +n+d++l++g            +e   ++i+e+++++ Pi+ +C+G Q++  ++ +     k+ + +ek++ g   + + d+++    l
  EFC36591.1  51 NSHQivqfIVQNYDAVLIPGSEDCCMddslcyIEVLCNVIRELIDRDFPIFAVCFGAQAVSRALNGndgvsKLKNLNEKPEFGIVlIDFVDEDArgnLL 149
                 22223335589*******987543335569999*********************************776663334444444444314555544478899 PP

                 GTTTTSEEEEEEEEEEEEESGCHHHTTEEEEEEEETTEEEEEEEEETTTEEEESSBTTSTTS CS
      GATase 115 lyglknevierhrHryevnpkelepaglevtakseddeelmeiiekknpfvgvQFHPEstst 176
                 ++g ++ ++ + +H++++     ++++ e + ks +  ++ + + k++  +g+QFHPE+ + 
  EFC36591.1 150 FRGIEKGFYSSSSHSDCFL----LNEKCEHLLKSRHW-KNQAYQVKDKLTFGLQFHPEMDLV 206
                 *****************99....57778888888776.466666555559********9765 PP

>> Peptidase_C26  Peptidase C26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.045   1.2e+02      48      69 ..      52      73 ..      45      78 .. 0.87
   2 !   16.7   0.0   1.9e-06    0.0049      96     125 ..      88     117 ..      84     132 .. 0.89
   3 ?    3.1   0.0     0.027        68     205     216 .]     191     202 ..     185     202 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.045
  Peptidase_C26 48 deedvkaildkldgllltGgqd 69
                   +++ v+ i+++ d++l++G++d
     EFC36591.1 52 SHQIVQFIVQNYDAVLIPGSED 73
                   5678999*************98 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 1.9e-06
  Peptidase_C26  96 aLiraalergvPilgiCrGlqllnvalGGt 125
                     +ir+ ++r++Pi+++C G q +  al G+
     EFC36591.1  88 NVIRELIDRDFPIFAVCFGAQAVSRALNGN 117
                    5799********************999996 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.027
  Peptidase_C26 205 kafvlgvQwHPE 216
                    ++  +g+Q+HPE
     EFC36591.1 191 DKLTFGLQFHPE 202
                    46899******9 PP

>> GATase_3  CobB/CobQ-like glutamine amidotransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.0     1e-08   2.6e-05      38      99 ..      56     121 ..      15     145 .. 0.82

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1e-08
    GATase_3  38 g....edadlvilpGgkdtiqdlallresgldeaikeaaeaggpvlgiCGGlqmLGeeiedpegve 99 
                      +++d+v++pG++d   d  l   + l + i+e++ ++ p++++C G q  ++ +   +gv 
  EFC36591.1  56 VqfivQNYDAVLIPGSEDCCMDDSLCYIEVLCNVIRELIDRDFPIFAVCFGAQAVSRALNGNDGVS 121
                 1445567***************************************************99999884 PP

>> GramPos_pilinBB  Gram-positive pilin backbone subunit 2, Cna-B-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.045   1.2e+02      15      35 ..      19      39 ..       9      67 .. 0.84
   2 !   16.3   0.2   5.3e-06     0.014      17      73 ..     182     238 ..     171     252 .. 0.79

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.045
                     TT--S--EEEEEEE-TTEEE- CS
  GramPos_pilinBB 15 etakyekykfsDtlskGLtyn 35
                     e++ ++ky+f+D +s+  +y+
       EFC36591.1 19 EDDLFKKYMFTDDISECTSYH 39
                     67889**********999987 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 5.3e-06
                      --S--EEEEEEE-TTEEE-TTT--EEEETT--TTTSEEEEEEE-TTS-EEEEEEE-H CS
  GramPos_pilinBB  17 akyekykfsDtlskGLtynedvkvkvdekdvvkdtdytvaekedgktlevevanlkk 73 
                       k+++y+++D+l+ GL+++ ++ +  +e+ + + +d+ v +++++k+++++v ++ +
       EFC36591.1 182 WKNQAYQVKDKLTFGLQFHPEMDLVTSEEIFKTLKDIPVLYDDNEKQVDMTVGKIMA 238
                      46789**************99999888888788999******999998888766643 PP

>> DJ-1_PfpI  DJ-1/PfpI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0     7e-07    0.0018      59     109 ..      60     112 ..      46     118 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 7e-07
                 CCG-SEEEE--BHHHHHHHHTS..HHHHHHHHHHHHTT-EEEEETTTHHHHHH CS
   DJ-1_PfpI  59 aaeyDalvlpGGragperlren..ekvvelvkefaekgklvaaICagpqlLaa 109
                 +++yDa+++pG +  + + + +  e++ ++++e  +++ +++a+C g+q  ++
  EFC36591.1  60 VQNYDAVLIPGSEDCCMDDSLCyiEVLCNVIRELIDRDFPIFAVCFGAQAVSR 112
                 789*********99886655552279**********************98776 PP

>> ThiJ_like  ThiJ/PfpI family-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   7.7e-06      0.02      77     142 ..      55     114 ..      23     125 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 7.7e-06
   ThiJ_like  77 sesFsleeydlvllpGGsdkavrell.eserlhsllveylklvkrekepskvlgaicqgvlalafak 142
                   +F +++yd+vl+pG +d ++ + l   e l ++++e +       +++  + a+c g+ a++ a 
  EFC36591.1  55 IVQFIVQNYDAVLIPGSEDCCMDDSLcYIEVLCNVIRELI-------DRDFPIFAVCFGAQAVSRAL 114
                 457899****************986625688888888888.......34568999999999999885 PP

>> SNO  SNO glutamine amidotransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   4.5e-05      0.12      32      97 ..      61     127 ..      50     215 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.5e-05
                 CC-SEEEE-SS-HHHHHH.HHHHTT-HHHHHHHHHTT.--EEEETHHHHHHCCEETTB.SS-SS--CC CS
         SNO  32 aevdaliiPGGestamsk.liertglyedllefvknsekvvlGtCaGlillskelene.lvktlellk 97 
                 ++ da++iPG e  +m   l     l + ++e + +   +++  C G   +s+ l+++  v +l+ l+
  EFC36591.1  61 QNYDAVLIPGSEDCCMDDsLCYIEVLCNVIRELIDRD-FPIFAVCFGAQAVSRALNGNdGVSKLKNLN 127
                 678*************861555556677777877766.*****************9885566666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       677  (0.0377601); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1559.64
//
Query:       EFC36592.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.035   14.0   0.0        0.1   12.5   0.0    1.8  1  F-box     F-box domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   5.8e-06       0.1       2      27 ..      93     118 ..      92     119 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.8e-06
                 HHHHS-HHHHHHHHHTS-HHHHHHHC CS
       F-box   2 tlsrLPsevlrhILerLplsdllalr 27 
                 ++ +LP ++ +hI+e+++l+++ +l+
  EFC36592.1  93 HFEQLPTDCFLHIFEFMELTEIKRLA 118
                 6899*****************98876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1640  (0.0914719); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.29s 00:00:00.99 Elapsed: 00:00:00.48
# Mc/sec: 3479.39
//
Query:       EFC36593.1  [L=690]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.8e-22   78.6   0.0      1e-21   77.6   0.0    1.6  1  HATPase_c     Histidine kinase-, DNA gyrase B-, and HSP90-lik
    4.7e-14   52.2   0.1    1.1e-13   51.0   0.1    1.7  1  HisKA         His Kinase A (phospho-acceptor) domain
    1.4e-05   24.9   0.0    7.3e-05   22.6   0.0    2.3  1  HATPase_c_5   GHKL domain
    2.4e-05   24.4   0.0      5e-05   23.4   0.0    1.5  1  Response_reg  Response regulator receiver domain


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.6   0.0   2.2e-25     1e-21       3     109 ..     463     576 ..     461     579 .. 0.91

  Alignments for each domain:
  == domain 1  score: 77.6 bits;  conditional E-value: 2.2e-25
                 HHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE...EE...TEEEEEEEESSSSSTTHHHTGTCSTTCH.HCSTCHTSTSSSHHHHHHHHHHHHTTTEEEE CS
   HATPase_c   3 ekrLrqiisnlvdNavkfatkageieveika...se...ddlvisveDnGiGipkedlkklfekfsq.ddstkrggggtGlGlsivkklvelmgGeiwv 94 
                 +++++qi+snl++Navk+++k+++++++++    ++   ++++++ +D G+Gip++ l+ +fe+f+q +++++++   +GlGl+ v  l+++++G+i+v
  EFC36593.1 463 PSKIHQILSNLLTNAVKASKKDDDVWLKCNIlekKDdetVKIRFTCQDFGCGIPPNLLESIFEPFVQlQNNSQSKVPSSGLGLTTVSHLIKTLNGTINV 561
                 6789**************88*******99997651156899999************************99999999************9999******* PP

                 EEETTTEEEEEEEEE CS
   HATPase_c  95 esepgrGttftftlp 109
                 es+ g+G++ft+ l 
  EFC36593.1 562 ESQVGIGSSFTVDLA 576
                 ***********9875 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.0   0.1   2.5e-17   1.1e-13       1      66 [.     343     407 ..     343     408 .. 0.97

  Alignments for each domain:
  == domain 1  score: 51.0 bits;  conditional E-value: 2.5e-17
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHC..T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH CS
       HisKA   1 slgrflagvaHELrtPLsailgnaeaLkregklteelkeyletiesearrldhlvedlLdlsriea 66 
                 +++rf+a+v+HE+r P+ + +g +e+Lk++ +l+e++ ++++ti+s+   ++ l+ed+L++ +ie+
  EFC36593.1 343 ARSRFIAHVSHEFRCPIMSSIGCLELLKET-PLNEKQNDLVDTIVSSNSVILLLIEDILQIVKIEH 407
                 589**************************6.*********************************97 PP

>> HATPase_c_5  GHKL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   1.6e-08   7.3e-05       4      92 ..     464     566 ..     461     577 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 1.6e-08
  HATPase_c_5   4 ldlcvilgnlLdNAieacskieeekrfIrltvrekkksliisieNsyeg..................ekkklesskskkeehGiGlksireivkkykg 83 
                    +  il+nlL NA+ a++k +  +  +++++ ekk++ +++i  ++++                  +    ++s+sk    G+Gl+++++++k+ +g
   EFC36593.1 464 SKIHQILSNLLTNAVKASKKDD--DVWLKCNILEKKDDETVKIRFTCQDfgcgippnllesifepfvQ--LQNNSQSKVPSSGLGLTTVSHLIKTLNG 557
                  56889**************977..899**********************99****9999877644322..33355677899***************** PP

  HATPase_c_5  84 nlsieaedg 92 
                  ++++e + g
   EFC36593.1 558 TINVESQVG 566
                  **9998755 PP

>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.0   1.1e-08     5e-05       1      51 [.     633     682 ..     633     683 .. 0.98

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 1.1e-08
                   EEEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHHHHHHESEEEEES CS
  Response_reg   1 vlivdDdplvrellrqlleeegyeevaeaedgkealellkeekvdlillDi 51 
                   vli++D+p++r+++ +++++ g  e++ + dgke++e+++ ++  ++++D+
    EFC36593.1 633 VLIAEDNPINRKVIVKMINSMGS-ETDFVCDGKELVEKFNPSTHKVVFTDM 682
                   8**********************.**************************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (690 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       864  (0.0481901); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.24s 00:00:00.91 Elapsed: 00:00:00.45
# Mc/sec: 4652.00
//
Query:       EFC36594.1  [L=178]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       335  (0.0186848); expected 358.6 (0.02)
Passed bias filter:                      311  (0.0173462); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1162.55
//
Query:       EFC36595.1  [L=1824]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1824 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1431  (0.0798148); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                       156  (0.00870099); expected 17.9 (0.001)
Passed Fwd filter:                        46  (0.00256568); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 4.60u 0.46s 00:00:05.05 Elapsed: 00:00:01.25
# Mc/sec: 4417.71
//
Query:       EFC36596.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-25   89.5  13.6    2.1e-25   89.5  13.6    1.4  2  Mod_r           Modifier of rudimentary (Mod(r)) protein
    1.3e-06   28.1   0.1    3.1e-06   26.9   0.1    1.7  1  UQ_con          Ubiquitin-conjugating enzyme
    0.00013   21.8   0.1    0.00033   20.5   0.1    1.7  1  UEV             UEV domain
  ------ inclusion threshold ------
      0.081   13.3   5.2       0.15   12.4   5.2    1.4  1  DUF641          Plant protein of unknown function (DUF641)
       0.47   10.7  11.6       0.13   12.5   8.2    1.8  2  KLRAQ           Predicted coiled-coil domain-containing prote
       0.73   10.3   6.7        2.3    8.7   0.1    2.4  2  Staphylokinase  Staphylokinase/Streptokinase family
        1.7    9.0   5.7         13    6.1   1.3    2.9  4  TOPRIM_C        C-terminal associated domain of TOPRIM
        3.6    8.5   7.2        1.8    9.5   4.4    2.0  2  Fes1            Nucleotide exchange factor Fes1


Domain annotation for each model (and alignments):
>> Mod_r  Modifier of rudimentary (Mod(r)) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0         5   1.1e+04      84     101 ..      65      82 ..      59      90 .. 0.53
   2 !   89.5  13.6   9.5e-29   2.1e-25       7     145 ..     284     427 ..     281     428 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 5
       Mod_r  84 ldellqkfspdallarLq 101
                 + + +++++ d++ +r++
  EFC36596.1  65 QAQRIRQLQADSIIKRFH 82 
                 444444444444444444 PP

  == domain 2  score: 89.5 bits;  conditional E-value: 9.5e-29
       Mod_r   7 eLqelledeeklealvktlpevkqlkeekeellaeneslaeknlsl.epeleelrselqekleelkelekefeekeqeldellqkfspdallarLqtav 104
                   q+ll++ee++++++++l+ +++ k+  ++l+++n+++a++  ++ e+  + l++++++k  e+++l ++++ +++++++l+q++ p  ll  L++++
  EFC36596.1 284 AVQKLLDSEELFKQFIENLSFTREAKNIYQDLRNANMDIAKRSVEKdEQINNTLKEQITQKKAEVDRLLDQVQFLQNKQQQLSQRYAPTQLLIMLNEKI 382
                 579*******************************************66667789********************************************* PP

       Mod_r 105 aeaeeeSealaeefle...ge.ieldeFvkefkekRklyHlrkeK 145
                 +e ++eSe++ + fl+    e  +++eF+++++ekR+ly+lr+ K
  EFC36596.1 383 DEVDNESEQVGDLFLDsptAEpHQVKEFIDKYLEKRTLYYLRRQK 427
                 ***************87*9666*********************99 PP

>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   0.1   1.4e-09   3.1e-06      39     111 ..      99     170 ..      62     187 .. 0.80

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 1.4e-09
                 TSTTTTEEEEEEEE--TTTTTS--EEEESST-SCTTBETTSBB-CGGGSTTT--TTSHHHHHHH.HHHHHHHS- CS
      UQ_con  39 dtpYeggvFklelefpedYPlkpPkvkfvtkifHPnvdksGevcldiLkeekWspaltlesvll.siqsLlaep 111
                  t+ +g+  ++++ +++ +P +pP ++  + i H nvd sG v    L+ + W+  ++l +vl+     ++++p
  EFC36596.1  99 ITLKNGQQITFRVLMQQAFPQQPPLITTLCTIKHANVDLSGYVVHPQLR-Q-WTQQSSLGDVLTiVFRDFINTP 170
                 5566677889999************************************.5.***********94445666666 PP

>> UEV  UEV domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   1.5e-07   0.00033      40     120 ..      98     171 ..      89     172 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.5e-07
                 E-SSSTTS-EEEEEEE--TTTTTS--EEEE-GCC--TSGGGGGB-TTSBB--HHHHS--TTT--HHHHHHHHHH-----XX CS
         UEV  40 pvkykgatyniPiliwvlesyPveaPivyvkptksmvikknenvdaqGlvylpyLeeWkreksnlvslvqelaqafeeesP 120
                 p++ k +  +i   + + +++P+++P++    t +     + nvd +G v +p L++W++ +s+l +++  +   f + +P
  EFC36596.1  98 PITLK-NGQQITFRVLMQQAFPQQPPLITTLCTIK-----HANVDLSGYVVHPQLRQWTQ-QSSLGDVLTIVFRDFINTPP 171
                 55555.44566677778899******997655543.....679****************9.88888888877777766666 PP

>> DUF641  Plant protein of unknown function (DUF641)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   5.2   6.6e-05      0.15      59     128 .]     297     368 ..     281     368 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.6e-05
      DUF641  59 lyrkkqkkkas..eaeeseleaeiqeqrsllktyeitvkkleaelkakdseieeLkekLeeaeksnkklekr 128
                 +++++ + +++  +  +   +a+++  ++ ++  e   + l++++++k++e+++L ++++ +++++++l++r
  EFC36596.1 297 QFIENLSFTREakNIYQDLRNANMDIAKRSVEKDEQINNTLKEQITQKKAEVDRLLDQVQFLQNKQQQLSQR 368
                 44443332222222556666777777999999***********************************99987 PP

>> KLRAQ  Predicted coiled-coil domain-containing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       2.7   6.1e+03      40      59 ..      67      86 ..      61     114 .. 0.61
   2 ?   12.5   8.2   5.7e-05      0.13       7      76 ..     312     382 ..     306     399 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.7
       KLRAQ 40 qslrkseqEvdsLtFrNkqL 59
                q +r+ +++     F N ++
  EFC36596.1 67 QRIRQLQADSIIKRFHNAKI 86
                44444444444444555444 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 5.7e-05
       KLRAQ   7 YsKlraqa.kvLkkavleEqskeaslkeelkekeqslrkseqEvdsLtFrNkqLekrvellqeeleveekk 76 
                 Y+ lr+ +  + k++v ++ + ++ lke++ +k++++ +    v+ L+ + +qL +r +  q  ++ +ek 
  EFC36596.1 312 YQDLRNANmDIAKRSVEKDEQINNTLKEQITQKKAEVDRLLDQVQFLQNKQQQLSQRYAPTQLLIMLNEKI 382
                 899997663799****999999***********************************99999888888765 PP

>> Staphylokinase  Staphylokinase/Streptokinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.1     0.001       2.3      35      66 ..     284     315 ..     273     325 .. 0.87
   2 ?    3.0   2.8      0.06   1.3e+02      17      75 ..     329     388 ..     316     392 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.001
  Staphylokinase  35 kigekltseeLlkaieeqLdardpaytiyqnd 66 
                     ++  +l seeL k+  e+L ++  a++iyq +
      EFC36596.1 284 AVQKLLDSEELFKQFIENLSFTREAKNIYQDL 315
                     67788************************975 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.06
  Staphylokinase  17 kkeellsplavelaikngkigekltseeLlkaieeqLdard.paytiyqnddsfeivdfd 75 
                     k+e+  ++l+ ++++k+ ++  +l   ++l+  ++qL +r+ p +++   ++ ++ vd++
      EFC36596.1 329 KDEQINNTLKEQITQKKAEVDRLLDQVQFLQNKQQQLSQRYaPTQLLIMLNEKIDEVDNE 388
                     778888899999***************************873555555555566666665 PP

>> TOPRIM_C  C-terminal associated domain of TOPRIM
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0      0.03        67      38      65 ..      50      77 ..      39      96 .. 0.81
   2 ?   -3.4   0.0       4.8   1.1e+04      96     117 ..     148     168 ..     145     169 .. 0.61
   3 ?    6.1   1.3    0.0058        13      49     111 ..     304     366 ..     300     379 .. 0.79
   4 ?   -2.9   0.0       3.4   7.6e+03     107     120 ..     402     415 ..     386     427 .. 0.66

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.03
    TOPRIM_C 38 kikYYkGLgtstskeakeyfsnldkhlk 65
                k+ YY G  t+t+++  +  ++l+   +
  EFC36596.1 50 KTSYYSGTTTTTTADQAQRIRQLQADSI 77
                578***************9999987654 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 4.8
    TOPRIM_C  96 klepgtyldkkkkkisysdFvn 117
                 ++++++ l   + +i ++dF+n
  EFC36596.1 148 QWTQQSSLGD-VLTIVFRDFIN 168
                 5555555533.33789999998 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0058
    TOPRIM_C  49 tskeakeyfsnldkhlkefkleeeedkeaielaFskkkaderkewlkklepgtyldkkkkkis 111
                  ++eak+++++l++  +++  ++ e++e+i++  +++ ++++ e  + l++ ++l++k++++s
  EFC36596.1 304 FTREAKNIYQDLRNANMDIAKRSVEKDEQINNTLKEQITQKKAEVDRLLDQVQFLQNKQQQLS 366
                 578******************************987765555444444556668887777765 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 3.4
    TOPRIM_C 107 kkkisysdFvnkeL 120
                  +  ++++F++k L
  EFC36596.1 402 AEPHQVKEFIDKYL 415
                 44556666776655 PP

>> Fes1  Nucleotide exchange factor Fes1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       5.3   1.2e+04      26      40 ..      61      74 ..      42      93 .. 0.57
   2 ?    9.5   4.4   0.00078       1.8      21      89 ..     316     384 ..     277     387 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 5.3
        Fes1 26 saaeaakask.ekldp 40
                ++a+  +a++ ++l+ 
  EFC36596.1 61 TTAD--QAQRiRQLQA 74
                2222..2223355543 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00078
        Fes1  21 eqeaesaaeaakask.ekldpeildallggpsdaelmkeamevledeevtlenkliAldnleqlieslDn 89 
                  + +  +a + +++k e++++ + +++ +++ +++++ +++++l++++++l +++   + l +l e++D 
  EFC36596.1 316 RNANMDIA-KRSVEKdEQINNTLKEQITQKKAEVDRLLDQVQFLQNKQQQLSQRYAPTQLLIMLNEKIDE 384
                 23333333.45566779***************************************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1684  (0.093926); expected 358.6 (0.02)
Passed bias filter:                      560  (0.0312343); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.41
# Mc/sec: 3197.10
//
Query:       EFC36597.1  [L=729]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-05   24.4   6.3    9.2e-05   22.7   6.3    2.0  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.098   13.0   2.3       0.34   11.2   2.3    2.0  1  DUF5601   Domain of unknown function (DUF5601)


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   6.3     1e-08   9.2e-05       8     117 ..     602     715 ..     574     716 .. 0.88

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 1e-08
                 SHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHHHHHHHHHH CS
         RGS   8 dqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke......qpsrklfeeaqeevfel 100
                 ++++++lF+ +++++ + enl + +   e k++ + +  ++++k I +e+l + s+ e+ni++++r++ e++l+++      + +++++ ++  e+ + 
  EFC36597.1 602 NEDLCQLFKLYCQKSLALENLMLMDVLIEKKRK-STSISVEDMKHIKEEFLISYSAYEVNISSQVRQNFEQNLQDAlskneaKVNNEILTDLMVEIETN 699
                 6679*****************999998888888.99999999*********************************999888877777777777777777 PP

                 HHHHHHHHHHTSHHHHH CS
         RGS 101 lekdsypkFlkselylr 117
                 ++ + + +F k+  +l+
  EFC36597.1 700 IK-STFMRFAKTSEFLE 715
                 75.46888888877765 PP

>> DUF5601  Domain of unknown function (DUF5601)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   2.3   3.8e-05      0.34      14      60 ..     656     700 ..     639     703 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 3.8e-05
     DUF5601  14 sisieelSemVqdFyqnlaerlnktplyktvsseavedlldeiEkyi 60 
                  + ++  S++ q+F qnl++ l+k+     v++e + dl+ eiE+ i
  EFC36597.1 656 AYEVNISSQVRQNFEQNLQDALSKN--EAKVNNEILTDLMVEIETNI 700
                 56677789999**************..7789*************977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (729 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1606  (0.0895755); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.46
# Mc/sec: 4742.35
//
Query:       EFC36598.1  [L=1066]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      4e-13   49.0   0.0    1.3e-12   47.3   0.0    2.0  1  RRM_1         RNA recognition motif. (a.k.a. RRM, RBD, or RNP
  ------ inclusion threshold ------
       0.12   12.8   2.6        6.6    7.4   0.2    3.0  2  TPR_17        Tetratricopeptide repeat
       0.17   12.1   2.9         16    5.8   0.1    3.1  2  ANAPC3        Anaphase-promoting complex, cyclosome, subunit 
       0.19   11.9   4.7        2.4    8.4   0.3    2.8  2  Phage_TAC_10  Phage tail assembly chaperone


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.3   0.0     3e-16   1.3e-12       1      65 [.     883     948 ..     883     950 .. 0.94

  Alignments for each domain:
  == domain 1  score: 47.3 bits;  conditional E-value: 3e-16
                 EEEESETTTSSHHHHHHHHHTTSCE.EEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEEET CS
       RRM_1   1 lfVgnLppdvteeeLkelFskfGpi.ksiklvrdetgkskgfafVeFeskedAekAlealngkklg 65 
                 ++V nLp++++e++++elF++     k+i+l++ e+g+skg+afVe es+e  ++A+e+ln++ ++
  EFC36598.1 883 VVVWNLPFSMKEQDIRELFQQHSIQaKRITLITRENGSSKGMAFVELESHEIIQQAIEKLNNYGID 948
                 6899*****************88777***********************************98776 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.2     0.013        58       1      24 [.     280     304 ..     280     331 .. 0.87
   2 ?    7.4   0.2    0.0015       6.6      18      34 .]     629     645 ..     628     645 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.013
      TPR_17   1 lylkalel.dPnnadaynnLAelll 24 
                 lylk l++ ++n+++  n +A+ll+
  EFC36598.1 280 LYLKYLKQyEKNHSKIRNIYANLLK 304
                 79******44888***********8 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0015
      TPR_17  18 nLAelllknGdlmtArq 34 
                 ++Ae+ll+nG++++A++
  EFC36598.1 629 QYAEFLLENGQSQRALE 645
                 79*************85 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.4    0.0063        28      13      56 ..     343     385 ..     330     389 .. 0.77
   2 ?    5.8   0.1    0.0035        16      26      49 ..     627     650 ..     603     657 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0063
                 HHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCTSHHHC-H CS
      ANAPC3  13 erllaaetespedayllAlclylngqykrAyellrkaklnsksl 56 
                 er+   +++  + + +l +  +++++y+ + ell++++ n+ sl
  EFC36598.1 343 ERIS-LQKQTQDESSYLEQINFEMKKYNNCKELLKSKEFNEMSL 385
                 5555.6666666666669******************97777776 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0035
                 HHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  26 ayllAlclylngqykrAyellrka 49 
                  + +A+ l++ngq +rA+e++++ 
  EFC36598.1 627 ELQYAEFLLENGQSQRALEFFENV 650
                 4569***************99987 PP

>> Phage_TAC_10  Phage tail assembly chaperone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.5     0.011        51      11      73 ..      43     105 ..      37     109 .. 0.79
   2 ?    8.4   0.3   0.00053       2.4       8      40 ..     535     567 ..     533     596 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.011
  Phage_TAC_10  11 rFevteeaYnkllNelapnnkvaPsknfLvrivaeeskealkeilatPgaalqiaekvneeyt 73 
                   +F+ +  a+n+  N ++ +++   sk    +i+++++ke+ +++++    +  + +k++++yt
    EFC36598.1  43 TFASSSLAFNNHNNLMNDEQVNEQSKASSSSIIDNDQKEDEENTMKLSEFKKTLLSKLSKQYT 105
                   7888888888865555544444567778889**********9999999999999999999998 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00053
  Phage_TAC_10   8 kdlrFevteeaYnkllNelapnnkvaPsknfLv 40 
                   +d+ F+ +++a n++ N+l+ n+      +f  
    EFC36598.1 535 NDIMFNKSMHALNSFANDLTFNDYYQVFSTFCS 567
                   69******************9997666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1066 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3604  (0.201015); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        98  (0.005466); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.23u 0.34s 00:00:01.57 Elapsed: 00:00:00.53
# Mc/sec: 6066.02
//
Query:       EFC36599.1  [L=440]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.2e-53  172.4   4.5     0.0002   21.1   0.0   12.3 12  LRR_6        Leucine Rich repeat
      2e-26   91.5  14.4    5.4e-06   26.1   0.1    6.2  8  LRR_8        Leucine rich repeat
    4.1e-26   90.6  13.1     0.0061   17.0   0.0    8.0 12  LRR_4        Leucine Rich repeats (2 copies)
    3.1e-13   48.3   4.4        6.5    7.7   0.1   11.2 12  LRR_1        Leucine Rich Repeat
      2e-07   30.6   5.7      0.027   14.0   0.2    4.2  4  LRR_9        Leucine-rich repeat
      5e-05   23.8   0.2         13    6.4   0.0    6.0  7  Apo-VLDL-II  Apovitellenin I (Apo-VLDL-II)
  ------ inclusion threshold ------
      0.018   15.3   1.3        2.7    8.3   0.1    3.6  3  DUF2513      Hypothetical protein (DUF2513)
      0.041   14.1  16.0        1.2    9.4   1.5    6.0  7  YjcQ         YjcQ protein
        2.1    7.9   4.4         29    4.1   0.1    3.7  4  Mgm101p      Mitochondrial genome maintenance MGM101


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0    0.0011       2.2       5      18 ..     121     134 ..     118     139 .. 0.94
   2 !   19.0   0.0   4.8e-07   0.00095       5      24 .]     145     164 ..     142     164 .. 0.92
   3 !   10.7   0.0   0.00022      0.44       5      24 .]     169     188 ..     166     188 .. 0.92
   4 !    6.9   0.0    0.0037       7.4       5      24 .]     193     212 ..     190     212 .. 0.92
   5 !   16.4   0.0   3.2e-06    0.0064       5      24 .]     217     236 ..     214     236 .. 0.92
   6 !   14.0   0.0     2e-05     0.041       5      24 .]     241     260 ..     238     260 .. 0.90
   7 !   14.7   0.0   1.2e-05     0.024       5      24 .]     265     284 ..     262     284 .. 0.92
   8 !   21.1   0.0     1e-07    0.0002       5      24 .]     289     308 ..     286     308 .. 0.93
   9 !    8.1   0.0    0.0015       3.1       5      24 .]     313     332 ..     310     332 .. 0.92
  10 !    8.1   0.0    0.0015         3       5      24 .]     337     356 ..     334     356 .. 0.91
  11 !   17.7   0.0   1.3e-06    0.0026       5      24 .]     361     380 ..     358     380 .. 0.91
  12 !   13.8   0.0   2.4e-05     0.047       5      24 .]     409     428 ..     406     428 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0011
       LRR_6   5 LteLdLsgNdIgDe 18 
                 Lt+L++ +N+IgDe
  EFC36599.1 121 LTSLNIYDNGIGDE 134
                 9************8 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 4.8e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N +gDeGa+ L+
  EFC36599.1 145 LTSLNIGYNRVGDEGAKYLS 164
                 9***************9885 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00022
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N +g eGa+ L+
  EFC36599.1 169 LTSLNIGYNRVGIEGAKYLS 188
                 9***************9885 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0037
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +  Ig eG++ ++
  EFC36599.1 193 LTSLNIGYSRIGIEGVKYIS 212
                 9***************9875 PP

  == domain 5  score: 16.4 bits;  conditional E-value: 3.2e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s N++++eGa+ L+
  EFC36599.1 217 LTSLNISKNEVSNEGAKYLS 236
                 9***************9885 PP

  == domain 6  score: 14.0 bits;  conditional E-value: 2e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ L++ +N+IgDeG++ L+
  EFC36599.1 241 LRLLNIYHNEIGDEGVKYLS 260
                 7889************9885 PP

  == domain 7  score: 14.7 bits;  conditional E-value: 1.2e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N Ig eG++ ++
  EFC36599.1 265 LTSLHIGYNRIGLEGVKLIS 284
                 9***************9985 PP

  == domain 8  score: 21.1 bits;  conditional E-value: 1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s N+I+DeGa+ L+
  EFC36599.1 289 LTSLDISENEISDEGAKYLS 308
                 9***************9885 PP

  == domain 9  score: 8.1 bits;  conditional E-value: 0.0015
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +  Ig eG++ ++
  EFC36599.1 313 LTSLNIDYSRIGLEGVKYIS 332
                 9***************9875 PP

  == domain 10  score: 8.1 bits;  conditional E-value: 0.0015
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L +++N Ig +Ga+ ++
  EFC36599.1 337 LTSLTIAYNRIGIKGAKLIS 356
                 9***************9885 PP

  == domain 11  score: 17.7 bits;  conditional E-value: 1.3e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ Ld+s N+I+DeGa+ L+
  EFC36599.1 361 LRLLDISNNEISDEGAKYLS 380
                 888*************9885 PP

  == domain 12  score: 13.8 bits;  conditional E-value: 2.4e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ Ld++ N Ig eGa+ L+
  EFC36599.1 409 LRLLDITRNRIGKEGAKLLS 428
                 888**************986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.4   4.8e+03       8      21 ..      36      49 ..      35      50 .. 0.83
   2 !   21.0   0.0   1.1e-07   0.00021       2      60 ..     120     178 ..     119     179 .. 0.97
   3 !   20.5   0.1   1.4e-07   0.00029       2      60 ..     144     202 ..     143     203 .. 0.95
   4 !   21.2   0.5   8.8e-08   0.00017       2      61 .]     192     251 ..     191     251 .. 0.96
   5 !   26.1   0.1   2.7e-09   5.4e-06       2      61 .]     264     323 ..     263     323 .. 0.96
   6 !   20.8   0.1   1.2e-07   0.00025       2      57 ..     336     391 ..     335     395 .. 0.93
   7 !   18.2   0.5   7.7e-07    0.0015       2      61 .]     360     419 ..     359     419 .. 0.97
   8 !    7.3   0.1     0.002         4      22      56 ..     404     438 ..     399     439 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.4
                -TTS--SEE-TTSS CS
       LRR_8  8 LsnNrltslddeaF 21
                +++  ++ ldd++F
  EFC36599.1 36 ICFEIISMLDDSWF 49
                67778999*****9 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 1.1e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +LtsL++ +N + + + +  + +++L++L++++N+     ++ +s +++L+sL++ +Nr
  EFC36599.1 120 QLTSLNIYDNGIGDEEIKYISEMKQLTSLNIGYNRVGDEGAKYLSEMKQLTSLNIGYNR 178
                 79*******************************************************98 PP

  == domain 3  score: 20.5 bits;  conditional E-value: 1.4e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +LtsL++  Nr  + + +  + +++L++L++++N+     ++ +s +++L+sL++ + r
  EFC36599.1 144 QLTSLNIGYNRVGDEGAKYLSEMKQLTSLNIGYNRVGIEGAKYLSEMEQLTSLNIGYSR 202
                 7*****************************************************98766 PP

  == domain 4  score: 21.2 bits;  conditional E-value: 8.8e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  +r+   + +  + +++L++L++s N+ +   ++ +s +++Lr L++ +N +
  EFC36599.1 192 QLTSLNIGYSRIGIEGVKYISEMKQLTSLNISKNEVSNEGAKYLSEMKQLRLLNIYHNEI 251
                 79********************************************************86 PP

  == domain 5  score: 26.1 bits;  conditional E-value: 2.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  Nr+   + +  + +++L++Ld+s+N+++   ++ +s +++L+sL++++ r+
  EFC36599.1 264 QLTSLHIGYNRIGLEGVKLISEMEQLTSLDISENEISDEGAKYLSEMEQLTSLNIDYSRI 323
                 7******************************************************98775 PP

  == domain 6  score: 20.8 bits;  conditional E-value: 1.2e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 +LtsL +  Nr+   + +  + +++L+ Ld+snN+++   ++ +s +++L sL++s
  EFC36599.1 336 QLTSLTIAYNRIGIKGAKLISEMKQLRLLDISNNEISDEGAKYLSEMKQLISLYIS 391
                 799***********************************999999999999999987 PP

  == domain 7  score: 18.2 bits;  conditional E-value: 7.7e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+ Ld+snN +++ + +  + +++L +L++s+  +     + +s +++Lr Ld+++Nr+
  EFC36599.1 360 QLRLLDISNNEISDEGAKYLSEMKQLISLYISEIGIGIKGVKYISEMKQLRLLDITRNRI 419
                 79********************************************************97 PP

  == domain 8  score: 7.3 bits;  conditional E-value: 0.002
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 + +++L+ Ld+++N++    ++ +s +++L+ L L
  EFC36599.1 404 SEMKQLRLLDITRNRIGKEGAKLLSEMKQLTPLCL 438
                 56888999999999998888888888888887755 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0052        10      20      38 ..     115     133 ..     102     138 .. 0.69
   2 !   17.0   0.0   3.1e-06    0.0061       1      36 [.     119     155 ..     119     160 .. 0.84
   3 !   16.9   0.0   3.2e-06    0.0064       1      35 [.     143     178 ..     143     184 .. 0.87
   4 !   12.1   0.0   0.00011      0.21       1      35 [.     167     202 ..     167     209 .. 0.81
   5 !   11.1   0.2   0.00021      0.42       2      38 ..     192     226 ..     191     237 .. 0.79
   6 !   14.8   0.6   1.5e-05     0.029       1      37 [.     215     252 ..     215     257 .. 0.86
   7 !   15.0   0.1   1.3e-05     0.026       1      36 [.     239     275 ..     239     282 .. 0.86
   8 !   14.9   0.0   1.3e-05     0.027       2      32 ..     288     320 ..     287     329 .. 0.85
   9 ?    3.5   0.0      0.05     1e+02      20      36 ..     332     347 ..     321     352 .. 0.74
  10 !   16.0   0.2     6e-06     0.012       1      38 [.     335     373 ..     335     381 .. 0.81
  11 !   15.2   0.1   1.1e-05     0.022       1      32 [.     359     392 ..     359     401 .. 0.89
  12 !    9.5   0.0   0.00067       1.3       1      37 [.     383     420 ..     383     429 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0052
                 HH.-TT--EEE-.-S----- CS
       LRR_4  20 ek.lpnLkeLdLsgNnlitd 38 
                  + +++L++L++ +N  i+d
  EFC36599.1 115 ISaMKQLTSLNIYDN-GIGD 133
                 344999999999666.7755 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 3.1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L++ +N + d +   ++ +++L++L++  N ++
  EFC36599.1 119 KQLTSLNIYDNGIGDEEIkyISEMKQLTSLNIGYN-RV 155
                 58*************99986445*********555.65 PP

  == domain 3  score: 16.9 bits;  conditional E-value: 3.2e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 ++L++L+++ N++ d +   l+ +++L++L++  N +
  EFC36599.1 143 KQLTSLNIGYNRVGDEGAkyLSEMKQLTSLNIGYN-R 178
                 58*************99998778*********556.4 PP

  == domain 4  score: 12.1 bits;  conditional E-value: 0.00011
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnl 35 
                 ++L++L+++ N++  i++   l+ + +L++L++ g ++
  EFC36599.1 167 KQLTSLNIGYNRVG-IEGakyLSEMEQLTSLNI-GYSR 202
                 58**********99.777677777*********.5434 PP

  == domain 5  score: 11.1 bits;  conditional E-value: 0.00021
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38 
                 +L++L+++  ++  i++   ++ +++L++L++s N     
  EFC36599.1 192 QLTSLNIGYSRIG-IEGvkyISEMKQLTSLNISKN----E 226
                 6999999966888.666554446*********999....4 PP

  == domain 6  score: 14.8 bits;  conditional E-value: 1.5e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L++s N ++  +   l+ +++L+ L++ +N  i+
  EFC36599.1 215 KQLTSLNISKNEVSNEGAkyLSEMKQLRLLNIYHN-EIG 252
                 58************877788777*********888.665 PP

  == domain 7  score: 15.0 bits;  conditional E-value: 1.3e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L+ L++ +N + d +   l+ +++L++L++  N +i
  EFC36599.1 239 KQLRLLNIYHNEIGDEGVkyLSEMKQLTSLHIGYN-RI 275
                 589************99998778*********556.66 PP

  == domain 8  score: 14.9 bits;  conditional E-value: 1.3e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsg 32 
                 +L++Ld+s N ++d +   l+ + +L++L++  
  EFC36599.1 288 QLTSLDISENEISDEGAkyLSEMEQLTSLNIDY 320
                 79************99998778********943 PP

  == domain 9  score: 3.5 bits;  conditional E-value: 0.05
                 HH-TT--EEE-.-S--- CS
       LRR_4  20 eklpnLkeLdLsgNnli 36 
                 + +++L++L++  N +i
  EFC36599.1 332 SEMKQLTSLTIAYN-RI 347
                 34999999999777.54 PP

  == domain 10  score: 16.0 bits;  conditional E-value: 6e-06
                 SS--EEE--SS---E-S-..HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L ++ N++  i +  l + +++L+ Ld+s+N  i+d
  EFC36599.1 335 KQLTSLTIAYNRIG-IKGakLISeMKQLRLLDISNN-EISD 373
                 58**********99.777675555*********666.6654 PP

  == domain 11  score: 15.2 bits;  conditional E-value: 1.1e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsg 32 
                 ++L+ Ld+snN ++d +   l+ +++L +L++s+
  EFC36599.1 359 KQLRLLDISNNEISDEGAkyLSEMKQLISLYISE 392
                 589************99998778********975 PP

  == domain 12  score: 9.5 bits;  conditional E-value: 0.00067
                 SS--EEE--..SS---E-S-HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLs..nNqltdiplleklpnLkeLdLsgNnlit 37 
                 ++L++L++s  +  ++ +  ++ +++L+ Ld+++N +i+
  EFC36599.1 383 KQLISLYISeiGIGIKGVKYISEMKQLRLLDITRN-RIG 420
                 57999****66677888777777*********999.664 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0      0.12   2.4e+02       1      20 [.     120     139 ..     120     142 .. 0.80
   2 ?    3.5   0.0      0.08   1.6e+02       1      20 [.     144     163 ..     144     166 .. 0.78
   3 ?    2.3   0.0       0.2   3.9e+02       1      12 [.     168     179 ..     168     190 .. 0.83
   4 ?    0.2   0.0      0.94   1.9e+03       1      12 [.     192     203 ..     192     212 .. 0.82
   5 ?    2.5   0.0      0.16   3.3e+02       1      15 [.     216     230 ..     216     238 .. 0.75
   6 ?    3.8   0.0     0.062   1.2e+02       1      20 [.     240     259 ..     240     262 .. 0.80
   7 ?    1.9   0.0      0.26   5.2e+02       1      12 [.     264     275 ..     264     285 .. 0.82
   8 ?    4.2   0.0     0.047        93       1      20 [.     288     307 ..     288     310 .. 0.82
   9 ?   -0.0   0.0       1.1   2.2e+03       1      12 [.     312     323 ..     312     333 .. 0.80
  10 ?   -1.3   0.0       2.9   5.8e+03       2      12 ..     337     347 ..     336     356 .. 0.81
  11 !    7.7   0.1    0.0032       6.5       1      21 [.     360     380 ..     360     391 .. 0.85
  12 ?    4.7   0.0     0.033        66       1      13 [.     408     424 ..     408     439 .. 0.68

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++ +n +++ ++ ++
  EFC36599.1 120 QLTSLNIYDNGIGDEEIKYI 139
                 599*******9988777665 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.08
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n+ ++ ++ ++
  EFC36599.1 144 QLTSLNIGYNRVGDEGAKYL 163
                 599*******9877666655 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.2
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++++n+ 
  EFC36599.1 168 QLTSLNIGYNRV 179
                 599*******84 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.94
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++++ ++
  EFC36599.1 192 QLTSLNIGYSRI 203
                 599****99876 PP

  == domain 5  score: 2.5 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L++s n  ++ 
  EFC36599.1 216 QLTSLNISKNEVSNE 230
                 599******986555 PP

  == domain 6  score: 3.8 bits;  conditional E-value: 0.062
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr L++ +n +++ +  ++
  EFC36599.1 240 QLRLLNIYHNEIGDEGVKYL 259
                 59*********988776665 PP

  == domain 7  score: 1.9 bits;  conditional E-value: 0.26
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++++n++
  EFC36599.1 264 QLTSLHIGYNRI 275
                 599*******98 PP

  == domain 8  score: 4.2 bits;  conditional E-value: 0.047
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+s n +++ ++ ++
  EFC36599.1 288 QLTSLDISENEISDEGAKYL 307
                 599********988887766 PP

  == domain 9  score: -0.0 bits;  conditional E-value: 1.1
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++ + ++
  EFC36599.1 312 QLTSLNIDYSRI 323
                 599****98876 PP

  == domain 10  score: -1.3 bits;  conditional E-value: 2.9
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L + +n++
  EFC36599.1 337 LTSLTIAYNRI 347
                 999****9997 PP

  == domain 11  score: 7.7 bits;  conditional E-value: 0.0032
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +Lr Ld+snn +++ ++ +++
  EFC36599.1 360 QLRLLDISNNEISDEGAKYLS 380
                 59*********9888777665 PP

  == domain 12  score: 4.7 bits;  conditional E-value: 0.033
       LRR_1   1 nLrhLdLsnnpl....l 13 
                 +Lr Ld+++n++     
  EFC36599.1 408 QLRLLDITRNRIgkegA 424
                 59*********944440 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.1    0.0035       6.9      14     118 ..      91     196 ..      83     203 .. 0.64
   2 !    6.6   0.1    0.0024       4.9      63     146 ..     166     245 ..     158     250 .. 0.74
   3 !    7.5   0.1    0.0013       2.6      50     120 ..     247     318 ..     238     323 .. 0.79
   4 !   14.0   0.2   1.3e-05     0.027      54     151 ..     325     418 ..     317     433 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0035
       LRR_9  14 qyinairereldlrgykipvienlGatldqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPla 110
                 q++n+i +     r  +      l +++ q+ ++++ dn i   ++  +  +k+l +l +  nr+   + +    + +l++l +  n++   +  + l 
  EFC36599.1  91 QFMNSIVKVKFSSRLLQAIETPKLISAMKQLTSLNIYDNGIgdEEIKYISEMKQLTSLNIGYNRVGDEGAKYLSEMKQLTSLNIGYNRVGIEG-AKYLS 188
                 556666555555555555555567778899999999999993335666667777777777777777666666666667777777777654333.25555 PP

       LRR_9 111 slkklell 118
                 ++++l++l
  EFC36599.1 189 EMEQLTSL 196
                 55555555 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0024
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                 +k+l +l +  nr+   + +    + +l++l +  +++  +  ++ + ++k+l++l + kn v+n+    +y +  +kqlrll+
  EFC36599.1 166 MKQLTSLNIGYNRVGIEGAKYLSEMEQLTSLNIGYSRIG-IEGVKYISEMKQLTSLNISKNEVSNEGA--KY-LSEMKQLRLLN 245
                 677777788888877766666666777888888888875.567899999************9998754..23.45677777775 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0013
       LRR_9  50 sdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsl 120
                   n+i +  +  +  +k+l +l +  nri   + +l   + +l++l +++ne+ + +  + l ++++l++l +
  EFC36599.1 247 YHNEIGDegVKYLSEMKQLTSLHIGYNRIGLEGVKLISEMEQLTSLDISENEISDEGA-KYLSEMEQLTSLNI 318
                 55666431144556688899999******************************99887.88999999988865 PP

  == domain 4  score: 14.0 bits;  conditional E-value: 1.3e-05
       LRR_9  54 irkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldfrkvk 151
                 +  +  +  +k+l +l ++ nri   + +l   + +l+ l ++nne+ + +  + l ++k+l +l + +  +  k       i  +kqlrlld  + +
  EFC36599.1 325 LEGVKYISEMKQLTSLTIAYNRIGIKGAKLISEMKQLRLLDISNNEISDEGA-KYLSEMKQLISLYISEIGIGIKG---VKYISEMKQLRLLDITRNR 418
                 44555566689999***********************************998.99*******99998888887664...3347899*******98755 PP

>> Apo-VLDL-II  Apovitellenin I (Apo-VLDL-II)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.1     0.036        71      46      71 ..      57      83 ..      47      92 .. 0.73
   2 ?    2.1   0.0      0.15     3e+02      26      67 ..     152     193 ..     148     200 .. 0.88
   3 ?    0.4   0.0      0.51     1e+03      26      57 ..     224     255 ..     220     266 .. 0.79
   4 ?   -0.0   0.0      0.68   1.4e+03      28      67 ..     250     289 ..     244     294 .. 0.86
   5 ?   -0.9   0.0       1.3   2.6e+03      27      47 ..     297     317 ..     292     339 .. 0.78
   6 ?   -0.5   0.0      0.92   1.8e+03      26      68 ..     344     386 ..     340     394 .. 0.66
   7 !    6.4   0.0    0.0067        13      32      67 ..     398     433 ..     384     436 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.036
  Apo-VLDL-II 46 vletrniliketakvsilfeq.lveki 71
                 +++    +ike +k++i+f++ + ek 
   EFC36599.1 57 ISKQFFKVIKERSKLAIQFQKkFTEKR 83
                 55555679**********975256664 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.15
  Apo-VLDL-II  26 vnkvsPkvaqflvdivqipvvletrniliketakvsilfeql 67 
                  +n+v    a++l ++ q + +    n++  e ak    +eql
   EFC36599.1 152 YNRVGDEGAKYLSEMKQLTSLNIGYNRVGIEGAKYLSEMEQL 193
                  689999999**********99999999999999988888887 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.51
  Apo-VLDL-II  26 vnkvsPkvaqflvdivqipvvletrniliket 57 
                   n vs   a++l ++ q  ++    n +  e 
   EFC36599.1 224 KNEVSNEGAKYLSEMKQLRLLNIYHNEIGDEG 255
                  699************99988877777666665 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 0.68
  Apo-VLDL-II  28 kvsPkvaqflvdivqipvvletrniliketakvsilfeql 67 
                   +     ++l ++ q + +    n++  e  k+   +eql
   EFC36599.1 250 EIGDEGVKYLSEMKQLTSLHIGYNRIGLEGVKLISEMEQL 289
                  555666799********************99999999998 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 1.3
  Apo-VLDL-II  27 nkvsPkvaqflvdivqipvvl 47 
                  n +s   a++l ++ q + + 
   EFC36599.1 297 NEISDEGAKYLSEMEQLTSLN 317
                  889999999999999988765 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 0.92
  Apo-VLDL-II  26 vnkvsPkvaqflvdivqipvvletrniliketakvsilfeqlv 68 
                  +n++  k a+ + ++ q  ++  + n +  e ak    + ql+
   EFC36599.1 344 YNRIGIKGAKLISEMKQLRLLDISNNEISDEGAKYLSEMKQLI 386
                  5666666777777777777777777777777666555555554 PP

  == domain 7  score: 6.4 bits;  conditional E-value: 0.0067
  Apo-VLDL-II  32 kvaqflvdivqipvvletrniliketakvsilfeql 67 
                  k  +++ ++ q  ++  trn++ ke ak+   + ql
   EFC36599.1 398 KGVKYISEMKQLRLLDITRNRIGKEGAKLLSEMKQL 433
                  6779999*********************97777666 PP

>> DUF2513  Hypothetical protein (DUF2513)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.1    0.0013       2.7      16     102 ..     147     231 ..     135     233 .. 0.84
   2 ?   -1.4   0.0       1.5   2.9e+03      66      89 ..     267     290 ..     236     305 .. 0.62
   3 ?    3.8   0.1     0.036        71      34      87 ..     310     360 ..     280     425 .. 0.64

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0013
     DUF2513  16 eletkeeslddeeekls.aidgyskeeiiyhlkllaeagLieaekkkakssiislvvkrLtweGhdFLdsiRddtvWkkvkeiakkkg 102
                 +l+ +++ + de +k+  ++++ ++ +i y    ++ a++++  ++ ++ +   + ++r+ +eG ++++++++ t ++  k+ ++++g
  EFC36599.1 147 SLNIGYNRVGDEGAKYLsEMKQLTSLNIGYNRVGIEGAKYLSEMEQLTSLN---IGYSRIGIEGVKYISEMKQLTSLNISKNEVSNEG 231
                 555666677777677767999999999999999999999999988877777...************************9999999876 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.5
     DUF2513  66 iislvvkrLtweGhdFLdsiRddt 89 
                 +  + ++r+  eG ++++++ + t
  EFC36599.1 267 SLHIGYNRIGLEGVKLISEMEQLT 290
                 455677777777777777766555 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.036
     DUF2513  34 idgyskeeiiyhlkllaeagLieaekkkakssiislvvkrLtweGhdFLdsiRd 87 
                 +++ ++ +i y    l+  ++i+  k+ ++ +   ++++r+ ++G ++++++++
  EFC36599.1 310 MEQLTSLNIDYSRIGLEGVKYISEMKQLTSLT---IAYNRIGIKGAKLISEMKQ 360
                 44444444444444444444444444444444...4455555555555444444 PP

>> YjcQ  YjcQ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   1.5   0.00059       1.2      21      79 ..     173     237 ..     160     245 .. 0.83
   2 ?   -1.3   0.0       1.3   2.6e+03      64      79 ..     246     261 ..     238     267 .. 0.81
   3 ?    3.1   0.1     0.057   1.1e+02      47      79 ..     277     309 ..     262     314 .. 0.90
   4 ?    0.8   0.0       0.3   5.9e+02      61      79 ..     315     333 ..     309     346 .. 0.85
   5 ?    3.6   0.2      0.04        79      46      79 ..     348     381 ..     330     386 .. 0.84
   6 ?    2.6   0.1     0.077   1.5e+02      51      79 ..     377     405 ..     374     416 .. 0.82
   7 ?    1.9   0.1      0.13   2.6e+02      47      77 ..     397     427 ..     383     433 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00059
                 ---HHHHTS-HHHHHHHHHHHHHHTS......EE--EESSS...SEE--SS--EE-HHHHHHHHH CS
        YjcQ  21 elsaekldisesrfndiiemlveegy......ikGvkvkktkkgeivisidnvritlkGleyLke 79 
                 ++ +++++i+ +++   +e+l   +       i+Gvk+++  k   +++i++ ++  +G +yL+e
  EFC36599.1 173 NIGYNRVGIEGAKYLSEMEQLTSLNIgysrigIEGVKYISEMKQLTSLNISKNEVSNEGAKYLSE 237
                 567889999999999999999876533366779********9999******************98 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.3
                 SS--EE-HHHHHHHHH CS
        YjcQ  64 idnvritlkGleyLke 79 
                 i + +i  +G++yL+e
  EFC36599.1 246 IYHNEIGDEGVKYLSE 261
                 566789999*****98 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.057
                 EE--EESSS...SEE--SS--EE-HHHHHHHHH CS
        YjcQ  47 ikGvkvkktkkgeivisidnvritlkGleyLke 79 
                 ++Gvk+++  +   ++ i++ +i  +G +yL+e
  EFC36599.1 277 LEGVKLISEMEQLTSLDISENEISDEGAKYLSE 309
                 57999999999999999**************98 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.3
                 E--SS--EE-HHHHHHHHH CS
        YjcQ  61 visidnvritlkGleyLke 79 
                 +++id +ri l+G++y++e
  EFC36599.1 315 SLNIDYSRIGLEGVKYISE 333
                 5788999*********998 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.04
                 SEE--EESSS...SEE--SS--EE-HHHHHHHHH CS
        YjcQ  46 yikGvkvkktkkgeivisidnvritlkGleyLke 79 
                  ikG k+++  k    + i+n +i  +G +yL+e
  EFC36599.1 348 GIKGAKLISEMKQLRLLDISNNEISDEGAKYLSE 381
                 599999999999899999**************98 PP

  == domain 6  score: 2.6 bits;  conditional E-value: 0.077
                 EESSS...SEE--SS--EE-HHHHHHHHH CS
        YjcQ  51 kvkktkkgeivisidnvritlkGleyLke 79 
                 k+ +  k  i+++i+++ i  kG++y++e
  EFC36599.1 377 KYLSEMKQLISLYISEIGIGIKGVKYISE 405
                 5555566679999*************998 PP

  == domain 7  score: 1.9 bits;  conditional E-value: 0.13
                 EE--EESSS...SEE--SS--EE-HHHHHHH CS
        YjcQ  47 ikGvkvkktkkgeivisidnvritlkGleyL 77 
                 ikGvk+++  k    + i + ri ++G + L
  EFC36599.1 397 IKGVKYISEMKQLRLLDITRNRIGKEGAKLL 427
                 5666666665555555566666666665555 PP

>> Mgm101p  Mitochondrial genome maintenance MGM101
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.7   3.4e+03      33      53 ..     155     175 ..     128     188 .. 0.71
   2 ?    4.1   0.1     0.015        29      10      51 ..     204     245 ..     195     261 .. 0.76
   3 ?    1.4   0.0       0.1     2e+02      22      55 ..     288     321 ..     267     359 .. 0.71
   4 ?    1.1   0.1      0.13   2.6e+02       9      51 ..     366     413 ..     357     428 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.7
     Mgm101p  33 ikpdGllYlpeikYrriLnka 53 
                 +  +G  Yl e+k    Ln  
  EFC36599.1 155 VGDEGAKYLSEMKQLTSLNIG 175
                 456777888888877777755 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.015
     Mgm101p  10 skkpfskeaadvllapleeedveikpdGllYlpeikYrriLn 51 
                 + + ++  ++   l++l+ +  e+  +G  Yl e+k  r Ln
  EFC36599.1 204 GIEGVKYISEMKQLTSLNISKNEVSNEGAKYLSEMKQLRLLN 245
                 5555554444455567777788999****************9 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.1
     Mgm101p  22 llapleeedveikpdGllYlpeikYrriLnkafG 55 
                  l++l+ ++ ei  +G  Yl e++    Ln  + 
  EFC36599.1 288 QLTSLDISENEISDEGAKYLSEMEQLTSLNIDYS 321
                 4556777777888899999999888888886655 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.13
     Mgm101p   9 lskkpfskeaadvlla.....pleeedveikpdGllYlpeikYrriLn 51 
                 +s++ +s+e a+ l +     +l  +++ i  +G+ Y+ e+k  r L+
  EFC36599.1 366 ISNNEISDEGAKYLSEmkqliSLYISEIGIGIKGVKYISEMKQLRLLD 413
                 555555555555554311111455678888999999999999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (440 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      250  (0.0139439); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 2578.21
//
Query:       EFC36600.1  [L=410]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5101  (0.284511); expected 358.6 (0.02)
Passed bias filter:                      579  (0.032294); expected 358.6 (0.02)
Passed Vit filter:                       219  (0.0122148); expected 17.9 (0.001)
Passed Fwd filter:                        77  (0.00429472); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.63u 0.40s 00:00:02.02 Elapsed: 00:00:00.59
# Mc/sec: 2084.74
//
Query:       EFC36601.1  [L=369]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (369 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       979  (0.0546043); expected 358.6 (0.02)
Passed bias filter:                      525  (0.0292822); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2247.98
//
Query:       EFC36602.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       556  (0.0310112); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 2276.14
//
Query:       EFC36603.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-06   26.1   1.6    5.4e-06   25.4   1.6    1.2  1  GNT-I     GNT-I family
    5.1e-06   25.8   0.3    1.2e-05   24.5   0.2    1.7  2  MGAT2     N-acetylglucosaminyltransferase II (MGAT2)


Domain annotation for each model (and alignments):
>> GNT-I  GNT-I family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.4   1.6   6.1e-10   5.4e-06      77     220 ..     249     399 ..     202     409 .. 0.73

  Alignments for each domain:
  == domain 1  score: 25.4 bits;  conditional E-value: 6.1e-10
       GNT-I  77 tvekkeiakldlkqakdviavlvlacsradavrrtvekllkyrpsaekfPlivsqdcsne.evkkevlsygdkvt...yikhldlesiave.Pderkl. 169
                 +    + +k + +q++d +++ + a +r++ +++ ++ l +    +e   liv+ d+++   v +e l+y d v+   y++   ++  + +  +++kl 
  EFC36603.1 249 KHFVLNAHKFNENQKEDHLPIWMRAYQRTTPLNQVLKALCQVTNIEET-ILIVTIDGDKFlPVIEELLKY-DCVKmriYFH--SFKHTSQNfVKDKKLy 343
                 3444566789999**************************999887766.6999****985379999****.6664222332..3333333333333330 PP

       GNT-I 170 .....tayykiarhyklaldqvfvkkkfsrviileddleiapdffdyfeataslld 220
                      +  +k+  h  + l   + k+k++ vi +edd++  pdf++y ++ + l  
  EFC36603.1 344 akaiiKQSFKLFAHASYGLYLCLIKFKYPYVITIEDDIKPLPDFYNYHRSLYRLTL 399
                 111114568899999999999****************************9998855 PP

>> MGAT2  N-acetylglucosaminyltransferase II (MGAT2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.5   0.2   1.4e-09   1.2e-05       6      86 ..     245     326 ..     241     341 .. 0.76
   2 ?   -3.0   0.0      0.32   2.9e+03     162     190 ..     372     400 ..     366     405 .. 0.80

  Alignments for each domain:
  == domain 1  score: 24.5 bits;  conditional E-value: 1.4e-09
       MGAT2   6 eaNekqevlnedkfgkla.kdelvivvqvhnrleylrlliesLekakgieeallvfshdv..yseeinelvqsidF.crvlqify 86 
                 ++Nek+ vln++kf++++ +d+l i ++ ++r++ l++++++L ++++iee++l+++ d   + + i+el++   + c  ++i++
  EFC36603.1 245 DMNEKHFVLNAHKFNENQkEDHLPIWMRAYQRTTPLNQVLKALCQVTNIEETILIVTIDGdkFLPVIEELLK---YdCVKMRIYF 326
                 79************986515677899******************************9874115555555554...3244455555 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.32
       MGAT2 162 glvlflEedhyvapdflhvlklleklkke 190
                  +v+ +E+d   +pdf+++ + l +l+ +
  EFC36603.1 372 PYVITIEDDIKPLPDFYNYHRSLYRLTLS 400
                 57899999999999999999988877655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.28s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 3307.61
//
Query:       EFC36604.1  [L=303]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00044   20.5   0.3     0.0087   16.4   0.0    2.6  2  EF-hand_9  EF-hand domain
     0.0018   18.0   1.4      0.038   13.9   0.3    3.1  3  EF-hand_6  EF-hand domain
      0.003   18.0   2.1       0.08   13.4   0.6    2.7  3  EF-hand_7  EF-hand domain pair
  ------ inclusion threshold ------
      0.023   14.5   0.6       0.65    9.9   0.0    2.7  2  EF-hand_8  EF-hand domain pair
      0.075   12.6   1.8        3.9    7.3   0.4    3.3  3  EF-hand_1  EF hand


Domain annotation for each model (and alignments):
>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   2.4e-06    0.0087      12      62 ..     136     188 ..     133     190 .. 0.87
   2 ?    1.1   0.0      0.15   5.2e+02       4      24 ..     206     226 ..     204     248 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.4e-06
   EF-hand_9  12 tGrVpvsrlidyLravtaqdpeeseLeelakelDPdge...dasvdldtflrvm 62 
                  G V +s+l++++r   + +p+eseL+++ + l   +e   +++v ld fl++m
  EFC36604.1 136 KGHVLLSDLLTLMRGLLK-NPKESELNQYLSVLPNCDEvieRKQVTLDEFLKIM 188
                 69**************99.**********9987333335659***********9 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.15
   EF-hand_9   4 FevcDtqktGrVpvsrlidyL 24 
                 Fe +Dt+  G +    l ++L
  EFC36604.1 206 FETFDTDFKGDIDPETLRNVL 226
                 999****99998766665555 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.3   4.7e+03      13      19 ..      27      33 ..      21      34 .. 0.72
   2 ?    1.1   0.0      0.13   4.8e+02      16      27 ..     178     189 ..     176     192 .. 0.86
   3 !   13.9   0.3   1.1e-05     0.038       2      27 ..     202     227 ..     201     244 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.3
   EF-hand_6 13 gdGkida 19
                 dG+++ 
  EFC36604.1 27 QDGYVTE 33
                89***96 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.13
   EF-hand_6  16 kidaeElrkalr 27 
                 +++ +E+ k++ 
  EFC36604.1 178 QVTLDEFLKIMA 189
                 699******985 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 1.1e-05
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalr 27 
                 + +aF+ fD+d  G id+e lr++l 
  EFC36604.1 202 ILDAFETFDTDFKGDIDPETLRNVLL 227
                 779********************986 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         4   1.4e+04      14      21 ..      26      33 ..      25      40 .. 0.76
   2 ?    3.1   0.0     0.037   1.3e+02      59      70 ..     177     188 ..     136     189 .. 0.75
   3 !   13.4   0.6   2.2e-05      0.08       4      53 ..     202     247 ..     200     264 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4
   EF-hand_7 14 dgdgyldk 21
                 +dgy+++
  EFC36604.1 26 QQDGYVTE 33
                57888876 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.037
   EF-hand_7  59 GvisfdEFlkly 70 
                  ++++dEFlk++
  EFC36604.1 177 KQVTLDEFLKIM 188
                 489******998 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 2.2e-05
   EF-hand_7   4 lkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkef 53 
                 + +aF+ +Dtd  g +d+e l+++l  +    g ++ +++ee++++++ f
  EFC36604.1 202 ILDAFETFDTDFKGDIDPETLRNVLLTM----GDKELVTKEEVDEIVNTF 247
                 789********************66655....7778889999**999987 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1     0.045   1.6e+02       3      16 ..     177     190 ..     175     212 .. 0.66
   2 ?    9.9   0.0   0.00018      0.65       2      35 ..     214     247 ..     214     247 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.045
   EF-hand_8   3 gkItreelrrilri 16 
                  ++t +e+ +i+++
  EFC36604.1 177 KQVTLDEFLKIMAL 190
                 67899999999943 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00018
   EF-hand_8   2 kgkItreelrril.rilglkkglseeevdilfref 35 
                 kg I++e+lr  l ++  ++  +++eevd+++++f
  EFC36604.1 214 KGDIDPETLRNVLlTMGDKE-LVTKEEVDEIVNTF 247
                 799********997775333.6**********987 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.76   2.7e+03      13      20 ..      27      34 ..      25      34 .. 0.82
   2 ?    2.6   0.0     0.034   1.2e+02      16      27 ..     178     189 ..     177     190 .. 0.88
   3 ?    7.3   0.4    0.0011       3.9       2      26 ..     202     226 ..     201     229 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.76
                SSSEEEHH CS
   EF-hand_1 13 gdGkIdfe 20
                +dG+++ +
  EFC36604.1 27 QDGYVTEQ 34
                7****975 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.034
                 EEEHHHHHHHHH CS
   EF-hand_1  16 kIdfeEfkellk 27 
                 +++++Ef+++++
  EFC36604.1 178 QVTLDEFLKIMA 189
                 689*******96 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0011
                 HHHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkell 26 
                 + ++F+ fD+D  G Id e ++++l
  EFC36604.1 202 ILDAFETFDTDFKGDIDPETLRNVL 226
                 679**************99999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (303 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       845  (0.0471303); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1754.35
//
Query:       EFC36605.1  [L=327]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   12.2   0.0       0.42   10.6   0.0    1.8  2  Slx4      Slx4 endonuclease
        1.1    9.5  11.0       0.14   12.3   6.3    2.1  2  SRTM1     Serine-rich and transmembrane domain-containing pro


Domain annotation for each model (and alignments):
>> Slx4  Slx4 endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   4.7e-05      0.42       8      39 ..      81     112 ..      76     122 .. 0.87
   2 ?   -3.1   0.0      0.91   8.2e+03      29      45 ..     280     296 ..     279     305 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 4.7e-05
                 HHT-HHHHHHHHTT--EEHHHHHHHHHHH-GG CS
        Slx4   8 iksdpslhekILlYePIvLedltawLnteglg 39 
                 i+s+psl+ kI+lY  + L+ + +  + e+++
  EFC36605.1  81 ITSSPSLLSKIYLYFSVFLSLFLQVFKCESMF 112
                 899*******************9999999774 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.91
                 HHHHHHHH-GGGGGS-H CS
        Slx4  29 ltawLnteglglkevdp 45 
                 + a Ln+++ ++k+ ++
  EFC36605.1 280 FLAALNSKDAFVKQNST 296
                 67889999887775544 PP

>> SRTM1  Serine-rich and transmembrane domain-containing protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   6.3   1.5e-05      0.14      18      53 ..      70     106 ..      52     157 .. 0.72
   2 ?   -3.6   0.1       1.4   1.3e+04      70      85 ..     234     245 ..     230     256 .. 0.54

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.5e-05
       SRTM1  18 eliptslstsvdass.grlsnvyvyvsiflsllafll 53 
                   +pt+ s+s  +ss + ls++y+y s+flsl+  ++
  EFC36605.1  70 ASLPTTTSSSPITSSpSLLSKIYLYFSVFLSLFLQVF 106
                 557999999999999899*************965433 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.4
       SRTM1  70 sssypecssdaGssft 85 
                 s    +c sda s+ t
  EFC36605.1 234 S----QCLSDAVSTTT 245
                 3....44455544443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (327 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       861  (0.0480228); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1824.44
//
Query:       EFC36606.1  [L=800]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (800 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1521  (0.0848346); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.49
# Mc/sec: 4924.98
//
Query:       EFC36607.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      1e-05   25.8   0.4     0.0026   18.0   0.0    2.3  2  EF-hand_9  EF-hand domain
      0.003   18.0   3.1     0.0089   16.5   2.1    2.1  2  EF-hand_7  EF-hand domain pair


Domain annotation for each model (and alignments):
>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   2.9e-07    0.0026      12      64 ..     175     229 ..     172     230 .. 0.90
   2 !    5.6   0.1    0.0022        20       4      60 ..     245     301 ..     243     305 .. 0.90

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 2.9e-07
   EF-hand_9  12 tGrVpvsrlidyLravtaqdpeeseLeelakelDPdge....dasvdldtflrvmre 64 
                  G V +s+l++++ra  + +p+e +L  + + l P+ e    + +++ld flr+m++
  EFC36607.1 175 KGHVLISDLLTLMRALMK-NPKEKDLPLYLSIL-PNSEevvnRCQLNLDEFLRIMQN 229
                 69***************9.*******9888877.7776699999***********97 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0022
   EF-hand_9   4 FevcDtqktGrVpvsrlidyLravtaq..dpeeseLeelakelDPdgedasvdldtflr 60 
                 Fe +D +  G+    +l+ +L  ++++  +++e   e l     P+++  s++ d fl+
  EFC36607.1 245 FETFDDDFKGEFEPEKLKFILATMGEKdlMTQEEIDEILLTFTNPENK--SIAYDEFLK 301
                 9*************************988899987788999999**99..999999986 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.21   1.9e+03      61      71 .]     218     228 ..     214     228 .. 0.85
   2 !   16.5   2.1     1e-06    0.0089       3      69 ..     240     302 ..     239     304 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.21
   EF-hand_7  61 isfdEFlklyr 71 
                 +++dEFl++++
  EFC36607.1 218 LNLDEFLRIMQ 228
                 78999999996 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 1e-06
   EF-hand_7   3 klkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkl 69 
                 k+ +aF+ +D d  g  ++e l+ ++ +     ge++ +++ee+++++  f    + +i +dEFlk 
  EFC36607.1 240 KILDAFETFDDDFKGEFEPEKLK-FILATM---GEKDLMTQEEIDEILLTFTNPENKSIAYDEFLKT 302
                 6889*******************.666543...*******************************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       637  (0.035529); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2010.21
//
Query:       EFC36608.1  [L=404]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.3e-12   44.7  20.0    2.2e-06   27.5   6.5    2.4  2  zf_CCCH_4    Zinc finger domain
    7.9e-09   35.2  18.3      4e-05   23.4   6.6    2.5  2  zf-CCCH      Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    8.2e-06   26.0  13.7      0.011   15.9   4.2    3.0  2  zf-CCCH_3    Zinc-finger containing family
    4.4e-05   23.2  21.0     0.0076   16.0   7.6    2.4  2  zf-CCCH_4    CCCH-type zinc finger
     0.0011   19.7  19.3     0.0022   18.7   4.7    3.0  3  Torus        Torus domain
  ------ inclusion threshold ------
        1.7    9.2  30.2      0.062   13.8   8.4    3.3  3  zf-CCCH_2    RNA-binding, Nab2-type zinc finger
          2    8.3  22.0        5.5    6.8  19.1    2.2  2  SRP-alpha_N  Signal recognition particle, alpha subunit, N-te
        5.4    5.7  10.6        7.8    5.2  10.6    1.2  1  Presenilin   Presenilin


Domain annotation for each model (and alignments):
>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   6.5     1e-09   2.2e-06       1      19 []     232     250 ..     232     250 .. 1.00
   2 !   23.0   5.6   2.5e-08   5.7e-05       1      19 []     257     276 ..     257     276 .. 1.00

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 1e-09
   zf_CCCH_4   1 CkfflqGtCkkGdkCrFaH 19 
                 Ckffl G+C kGd+C+F+H
  EFC36608.1 232 CKFFLHGNCHKGDSCPFSH 250
                 ******************* PP

  == domain 2  score: 23.0 bits;  conditional E-value: 2.5e-08
   zf_CCCH_4   1 Ckfflq.GtCkkGdkCrFaH 19 
                 Ckff+  ++CkkGd+C F+H
  EFC36608.1 257 CKFFHLyNSCKKGDSCEFSH 276
                 ******************** PP

>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   3.8   1.1e-06    0.0025       6      26 ..     232     251 ..     232     252 .. 0.88
   2 !   23.4   6.6   1.8e-08     4e-05       1      26 [.     252     277 ..     252     278 .. 0.95

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 1.1e-06
                 BCHHHHHS--TTGGG-SSBSC CS
     zf-CCCH   6 CrffmrtGyCkyGdrCkFaHg 26 
                 C+ff+  G C+ Gd+C+F+H+
  EFC36608.1 232 CKFFLH-GNCHKGDSCPFSHD 251
                 896666.*************8 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 1.8e-08
                 -HCHCBCHHHHHS--TTGGG-SSBSC CS
     zf-CCCH   1 yktelCrffmrtGyCkyGdrCkFaHg 26 
                 +kt +C+ff+ + +Ck Gd+C F+H 
  EFC36608.1 252 KKTFPCKFFHLYNSCKKGDSCEFSHH 277
                 5999*********************7 PP

>> zf-CCCH_3  Zinc-finger containing family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   4.2   5.1e-06     0.011       6      31 ..     230     255 ..     226     258 .. 0.87
   2 !   13.3   3.6   3.2e-05     0.071       8      27 ..     257     277 ..     251     282 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 5.1e-06
   zf-CCCH_3   6 ddcyffyystctkGdscpfrheeaal 31 
                 d c ff + +c+kGdscpf h + ++
  EFC36608.1 230 DFCKFFLHGNCHKGDSCPFSHDKKTF 255
                 66*******************98765 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 3.2e-05
   zf-CCCH_3   8 cyff.yystctkGdscpfrhe 27 
                 c ff  y  c+kGdsc f h 
  EFC36608.1 257 CKFFhLYNSCKKGDSCEFSHH 277
                 655527************996 PP

>> zf-CCCH_4  CCCH-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   7.6   3.4e-06    0.0076       3      22 .]     232     251 ..     231     251 .. 0.98
   2 !   12.8   5.4   3.6e-05     0.081       2      21 ..     256     276 ..     256     277 .. 0.95

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 3.4e-06
   zf-CCCH_4   3 CpyfakGsCrfGdnCrFsHd 22 
                 C++f++G+C  Gd C FsHd
  EFC36608.1 232 CKFFLHGNCHKGDSCPFSHD 251
                 *******************9 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 3.6e-05
   zf-CCCH_4   2 lCpyfa.kGsCrfGdnCrFsH 21 
                 +C++f   +sC+ Gd C FsH
  EFC36608.1 256 PCKFFHlYNSCKKGDSCEFSH 276
                 8****9899************ PP

>> Torus  Torus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.3       1.6   3.5e+03       4      54 ..     117     126 ..      84     141 .. 0.50
   2 !   18.7   4.7   9.7e-07    0.0022      33      92 ..     189     251 ..     159     254 .. 0.58
   3 !   10.7   1.4   0.00029      0.66      69      98 ..     253     283 ..     251     292 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.6
                 X----S-SS--------SSS-----TTSS----S-THHHHS-----S---- CS
       Torus   4 rparkqvdeeelksekeeqegeeyNiWynkwsgeekekkkkskekaktrcn 54 
                 + +rkq                                          + n
  EFC36608.1 117 KVTRKQK-----------------------------------------KKN 126
                 2222222.........................................222 PP

  == domain 2  score: 18.7 bits;  conditional E-value: 9.7e-07
                 ----S-THHHHS-----S----HHHH----HHHHSTT-......-B-HHHHHT--SSGGG-SSB-S CS
       Torus  33 kwsgeekekkkkskekaktrcnikkdsGytkadkekes......yfClfFarGlCakGkkCeylHr 92 
                 k    ++ +k++++++ k r + k d   +k  k  e        fC fF +G C+kG +C + H+
  EFC36608.1 189 KK---SSPSKSNKTKQDKKRKQKKDDRSAHKKFKVMEPkeplvkDFCKFFLHGNCHKGDSCPFSHD 251
                 22...2333334444455555555555555555443334456669*******************96 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00029
                 T--B-HHHH.HT--SSGGG-SSB-S---SS- CS
       Torus  69 esyfClfFa.rGlCakGkkCeylHrlPteed 98 
                 +++ C fF     C+kG +Ce+ H+ P ++ 
  EFC36608.1 253 KTFPCKFFHlYNSCKKGDSCEFSHHTPLSDA 283
                 5677888862578**************8765 PP

>> zf-CCCH_2  RNA-binding, Nab2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   8.4   2.8e-05     0.062       2      17 ..     232     250 ..     232     250 .. 0.99
   2 ?    7.2   5.6    0.0033       7.4       1      17 [.     256     276 ..     256     276 .. 0.97
   3 ?   -1.0   1.2       1.3   2.9e+03      14      18 .]     397     401 ..     397     401 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.8e-05
   zf-CCCH_2   2 Crffpn..C.tnpkCpFaH 17 
                 C+ff +  C ++++CpF+H
  EFC36608.1 232 CKFFLHgnChKGDSCPFSH 250
                 ******************* PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0033
   zf-CCCH_2   1 pCrffpn...C.tnpkCpFaH 17 
                 pC+ff     C ++++C F+H
  EFC36608.1 256 PCKFFHLynsCkKGDSCEFSH 276
                 8****99999*********** PP

  == domain 3  score: -1.0 bits;  conditional E-value: 1.3
   zf-CCCH_2  14 pFaHP 18 
                 pF+HP
  EFC36608.1 397 PFIHP 401
                 7***9 PP

>> SRP-alpha_N  Signal recognition particle, alpha subunit, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8  19.1    0.0025       5.5     127     235 ..     104     213 ..      30     233 .. 0.49
   2 ?    2.2   0.0     0.065   1.5e+02      68     119 ..     259     309 ..     257     368 .. 0.71

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0025
                  XXXXXXX.....XX.XX.................XXXXXXX...XXXXXXXXXX.........XXXXXXX.XXX.XXXXXXXXXXXXXX..XXXXXXX CS
  SRP-alpha_N 127 kkskktvksskedkkpe......gkkkkgakkekdasddstpsatpetsrpstp.........sglltakeagptaedvsrrarkkankkrssagass 209
                   k+++++      +kp+      ++kkk+ ++e+  +++++ +a+p+ s+ + p         ++++++ +++  +e++++ +++++ +       ++
   EFC36608.1 104 MKKSNSN------EKPKikkvtrKQKKKNITSEE--ASSNETVANPSLSNLEIPseivpinnlENNSKQIREEFLVEKIDETQKHEKVT-------KQ 186
                  1111111......111111111122222222221..22333333344444444444455433322222222333444444444433222.......22 PP

                  XXXX.....XXXXXXX..XXXXXX.XXX CS
  SRP-alpha_N 210 gdea.kasksskkkkkkpkkkgkk.aRv 235
                  g+++ ++sks+k +k+++k+k+kk  R 
   EFC36608.1 187 GKKKsSPSKSNK-TKQDKKRKQKKdDRS 213
                  222202222222.222223333332443 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.065
                  HHHHHGGGGG.SS-S----TT...HHHHHHHHHHHHXXXXXXXXX........X CS
  SRP-alpha_N  68 FvdlYkpklk.pkttlvecaksy.FdeyFdqllrelEasaeaakkskaakepka 119
                  F  lY++  k +++ + +    +   + ++qll + E++ +++ +++++++p+ 
   EFC36608.1 259 FFHLYNSCKKgDSCEFSHH---TpLSDAYRQLLMNTEKKFAQEPAKEESSNPNP 309
                  5556666444222222222...347899***********999877777665443 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2  10.6    0.0035       7.8     232     310 ..     104     210 ..      82     252 .. 0.51

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0035
  Presenilin 232 vaeseeeeeaekkkeeasesskeeeseeesseksaqsse...................................seeeseeesseaessaeesseekes 295
                 +++s+++e+ + kk + ++++k+ +see ss+  ++ ++                                   +    ++++++++++ +++s++++s
  EFC36608.1 104 MKKSNSNEKPKIKKVTRKQKKKNITSEEASSN--ETVANpslsnleipseivpinnlennskqireeflvekidE----TQKHEKVTKQGKKKSSPSKS 196
                 22222222222222222222222222222222..22222457788899999999999988888888888754431....22222222222222222222 PP

  Presenilin 296 eessesseeeeeeee 310
                 +++++ +++++++ +
  EFC36608.1 197 NKTKQDKKRKQKK-D 210
                 2211111111111.1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (404 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2519  (0.140499); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.54
# Mc/sec: 2263.24
//
Query:       EFC36609.1  [L=519]
Description: hypothetical protein NAEGRDRAFT_75708 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-46  158.5   0.0    3.2e-46  158.0   0.0    1.2  1  FAD-oxidase_C  FAD linked oxidases, C-terminal domain
    1.5e-30  105.7   0.4    2.8e-30  104.9   0.4    1.5  1  FAD_binding_4  FAD binding domain


Domain annotation for each model (and alignments):
>> FAD-oxidase_C  FAD linked oxidases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.0   0.0   3.6e-50   3.2e-46       9     250 .]     267     516 ..     259     516 .. 0.94

  Alignments for each domain:
  == domain 1  score: 158.0 bits;  conditional E-value: 3.6e-50
                    EEEESSHHHHHHHHHHHHHHT-.--SEEEEE-HHHHHHHHHTS-SSTTS-TTT-EEEEEEEEE-HHHHHHHHHHHHHHHTTT-EEEEE........ CS
  FAD-oxidase_C   9 lvafpsfeaavkavreiaqagi.ipaalelmdkkaldlveatkgakkglpdeeealllvefegddeeeaeeelealveaileatgaadvlvaqdea 103
                     v f+s+ +a+k+v e++++g+   a++el++k  +++v+++ +     + e  ++l++ef+g de+ ++   e  ve+i++++g+ + l ++de+
     EFC36609.1 267 RVIFNSISDAAKTVIEVKSRGVsNMARCELINKYGIMAVNKQFNR----DFEVSPTLFFEFHGADEASLKVSSE-IVEEIAKKHGGREYLATTDEN 357
                    5779****************6527999******************....****************988888888.********************* PP

                    ..ETGGGGGGGGHH..HHHHHHHCTTEEEEEEEEEEEHHHHHHHHHHHHHHHHHHH..........EEEEEEEEEETTEEEEEEEEEEE..--TT- CS
  FAD-oxidase_C 104 eaealwkaRkaalp..ylrdallkagvavlseDtsvPvsrladlvrdikalldkyg..........levvlfgHagdgnlhlyilfdladeaeeer 187
                    e++++w+aR++++      + ++k  v  +++D++vPvs+lad+++  ++ + +++          l  +++gH+gdgn+h++i +  ++++e e+
     EFC36609.1 358 EQKEVWHARRNVYYaaFKLKEGKKGDVKLYVTDVCVPVSKLADIIELSERDVVEFNenqaktgnftLPPAIVGHVGDGNFHFMIPYLDSNKQELET 453
                    ************99333344456666788******************************************************************* PP

                    -THHHHHHHHHHHHTT-----------------------THHHHHHHHHHHH-TT--BSTT-- CS
  FAD-oxidase_C 188 aeklvdevvdlavelgGsisgEHGvGldkkaylerekgeeglalmrriKaalDPkgiLNPgkv 250
                    + ++ d + ++a+e +G++sgEHGvG+ k++ l++e ++e+++lmr +K+a+D + +LN gkv
     EFC36609.1 454 ILQFNDVLIKRAIERDGTCSGEHGVGIGKQEGLYTEHDPEAVNLMRVLKRAIDKNLVLNTGKV 516
                    *************************************************************97 PP

>> FAD_binding_4  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.9   0.4   3.2e-34   2.8e-30       2     138 ..      85     222 ..      84     223 .. 0.94

  Alignments for each domain:
  == domain 1  score: 104.9 bits;  conditional E-value: 3.2e-34
                    EEEEEESSHHHHHHHHHHHHHCTSCEEEESSSTTEESTTC.SCCEEEEEETTS--EEEEETTTTEEEEETTSBHHHHHHHHHHHTTECSSGGGTTC CS
  FAD_binding_4   2 aavvrpeseeevaaalrlaneaglpvlvrGgGssllgqav.atggvvldlsrlnrileideeegtatveaGvtlgdlvealaakglllglepgsgi 96 
                    +++v+p+s eev+++++l+ +++lp++++G+ ++l g+av + ggv ++++ ++++l++ ee+ +++v+ G++ ++l+e+l+ kgl++ ++pgs  
     EFC36609.1  85 DVLVFPTSNEEVSKIMALCVREKLPIVAQGTLTGLEGGAVpYHGGVAVNMRLMRSVLHLYEEDLQVKVQTGIKKSELNEYLENKGLMFAVDPGS-- 178
                    689*********************************999999********66******************************************.. PP

                    GSBHHHTTTTT-EETTEEGG--HHGTEEEEEEEE..TTSEEEEE CS
  FAD_binding_4  97 pgtvGGaiatnagGygsekyGlirdnvlglevvl..adGevvrl 138
                    ++++GG ++t+a+G+ s  +G+ir+nvl+ +vvl   +G+++++
     EFC36609.1 179 DSSIGGQLSTGASGTLSVAHGTIRENVLQIKVVLpdENGTIITT 222
                    578*******************************5456887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (519 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      508  (0.028334); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.35s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 2913.66
//
Query:       EFC36610.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-09   37.5   0.6    1.3e-09   37.5   0.6    2.2  2  SHOCT     Short C-terminal domain


Domain annotation for each model (and alignments):
>> SHOCT  Short C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.2      0.07   1.3e+03      16      22 ..      31      37 ..      31      37 .. 0.87
   2 !   37.5   0.6   7.4e-14   1.3e-09       3      28 .]     185     210 ..     183     210 .. 0.96

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.07
       SHOCT 16 teEEFea 22
                +++EFe+
  EFC36610.1 31 SDAEFEK 37
                79***96 PP

  == domain 2  score: 37.5 bits;  conditional E-value: 7.4e-14
       SHOCT   3 LekLkeLyarGeIteEEFeakKakLL 28 
                 LekL++L+++G++teEEF akK+ +L
  EFC36610.1 185 LEKLASLRDSGILTEEEFTAKKRVIL 210
                 9**********************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1195  (0.0666518); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.45
# Mc/sec: 1411.40
//
Query:       EFC36611.1  [L=504]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00038   20.2   0.0      0.034   13.8   0.0    2.3  2  Abhydrolase_1  alpha/beta hydrolase fold
      0.001   18.4   0.0       0.11   11.8   0.0    3.0  2  Hydrolase_4    Serine aminopeptidase, S33
  ------ inclusion threshold ------
      0.051   12.7   0.1       0.47    9.5   0.0    2.1  2  DUF1749        Protein of unknown function (DUF1749)
       0.19   10.9   0.7       0.53    9.4   0.4    1.8  2  Tubulin_2      Tubulin like


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   7.5e-06     0.034       3      94 ..     169     291 ..     167     299 .. 0.75
   2 !    4.2   0.0    0.0066        30     206     256 ..     410     468 ..     344     469 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 7.5e-06
                    EEEE-STTTCGGGGTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB.CHH...............................SHHHHHHHHHHHH CS
  Abhydrolase_1   3 lvilhGlpgssdvwaerglapaLakdgfdvillDlrGvgySspapacinddy...............................gtasvaddldril 67 
                    + il+Gl g+ +    + l++ + k+g++++++D       s  +   ++                                 +  +++++++ ++
     EFC36611.1 169 IFILPGLSGGTGAVGVKHLISSFVKAGYRCVVMDYKTTSNESSTIQHGHH-TlppivgdldpidldkpkstnqttkvipglthTVKDIRNVIQLVR 263
                    78999999988776666799999999*******98766655555543332.146666666777888888888888889966655556677777779 PP

                    HHCTTSSEE.EEEETHHHHHHHHHHHHH CS
  Abhydrolase_1  68 dalgddklt.lvGhSmGGmialayaaey 94 
                       g d+    vG+S+G  + l+y++e+
     EFC36611.1 264 KEVGKDETLvGVGFSLGANTLLTYLSEH 291
                    99999988879***************99 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0066
                    C.......THHHHSEEEEEEETTCSSSCHHHHHHHHHC.HTSEEEEEEETCSSSHHHHS CS
  Abhydrolase_1 206 e.......lknvlaptlvisgtsDplvppkaledlaql.lpkkrlvvisdagHlafleg 256
                    e        k++++pt+ + + +Dp+ +++++ + a     k  lv+   +gH+a l+g
     EFC36611.1 410 EfhssgnkMKKITVPTICLNALDDPISTYSSIPFEAFVnYDKLMLVTTTRGGHIASLDG 468
                    02223334789999****************99998866444477888888888888876 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.0   2.4e-05      0.11      49      98 ..     242     292 ..     163     298 .. 0.76
   2 ?    2.4   0.0     0.017        76     149     208 ..     383     439 ..     328     451 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.4e-05
  Hydrolase_4  49 rghvpsfddyvdDlaafvekvkeehpel.plfllGhSmGGliallyllryp 98 
                  +  +p +++ v+D++ +++ v++e ++   l+ +G S+G+ + l+yl ++ 
   EFC36611.1 242 TKVIPGLTHTVKDIRNVIQLVRKEVGKDeTLVGVGFSLGANTLLTYLSEHV 292
                  44689999**************77666659999**************8875 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.017
  Hydrolase_4 149 srdpevvaayeadplvhgki.tvrlllelldamkrleeraakitlPllllhGeaDkvvdpe 208
                   r ++ v+   + pl+ gk+  v+ ++e++  +++     +kit+P++ l + +D++  ++
   EFC36611.1 383 LRTTRDVDDKINRPLCEGKFeNVEKFYEFHSSGNK----MKKITVPTICLNALDDPISTYS 439
                  56667777778888885555156777777777654....5789*************98876 PP

>> DUF1749  Protein of unknown function (DUF1749)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0     0.053   2.4e+02      27      66 ..     162     201 ..     141     220 .. 0.73
   2 ?    9.5   0.0   0.00011      0.47      79     136 ..     247     301 ..     243     385 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.053
     DUF1749  27 elkskallFi.gGLgdGlltvpyvkelanaldeagwsvvel 66 
                 + ++k+ +Fi  GL+ G ++v  vk+l  ++ +ag+  v +
  EFC36611.1 162 SERKKTTIFIlPGLSGGTGAVG-VKHLISSFVKAGYRCVVM 201
                 334555555438******9998.899999999999976544 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00011
     DUF1749  79 sLkrDaeeieklveYlkktksGeekkekvvlmGHstGsqdvlyYltssnerdrekvdg 136
                 +L + +++i+++++ ++k+  G  k e +v +G s G+   l+Yl+++  +d++k +g
  EFC36611.1 247 GLTHTVKDIRNVIQLVRKE-VG--KDETLVGVGFSLGANTLLTYLSEHVGKDAPKKQG 301
                 6788899***********9.57..88999*******************9988554444 PP

>> Tubulin_2  Tubulin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.17   7.5e+02      87     117 ..     121     153 ..     102     159 .. 0.67
   2 ?    9.4   0.4   0.00012      0.53     147     170 ..     158     181 ..     137     184 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.17
   Tubulin_2  87 reeta.saypsie.eWlppeleelrkapeseGA 117
                 r+++  +    i+ +W+ p ++++++ ++  GA
  EFC36611.1 121 RNQYEfEDGATINlDWFEPANTTTTNSSSDGGA 153
                 333334344556669******999999986665 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00012
   Tubulin_2 147 rgsage.eeglnvfVvgSLaGGTGS 170
                 +g+ ++ +++ ++f++ +L+GGTG+
  EFC36611.1 158 TGQ-QSeRKKTTIFILPGLSGGTGA 181
                 333.444888**************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (504 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       717  (0.0399911); expected 358.6 (0.02)
Passed bias filter:                      536  (0.0298957); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 2942.52
//
Query:       EFC36612.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.8e-12   46.2   0.1    1.5e-11   44.3   0.0    1.8  2  FMN_red       NADPH-dependent FMN reductase
    0.00018   21.3   0.0    0.00037   20.2   0.0    1.5  1  Flavodoxin_2  Flavodoxin-like fold
     0.0013   19.0   0.0     0.0083   16.4   0.0    2.2  2  Flavodoxin_5  Flavodoxin domain
      0.003   17.8   0.0        3.5    7.8   0.0    2.5  2  Flavodoxin_1  Flavodoxin
  ------ inclusion threshold ------
      0.047   14.4   0.5        1.4    9.6   0.0    2.5  2  PTS_IIB       PTS system, Lactose/Cellobiose specific IIB sub
       0.09   12.5   8.5       0.12   12.1   8.5    1.1  1  PAP1          Transcription factor PAP1
        1.5    9.4   9.0        2.2    8.8   9.0    1.2  1  TCP           TCP family transcription factor


Domain annotation for each model (and alignments):
>> FMN_red  NADPH-dependent FMN reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.3   0.0   5.8e-15   1.5e-11      18     131 ..      17     132 ..       3     150 .. 0.73
   2 ?   -1.0   0.0      0.52   1.3e+03      13      37 ..     172     197 ..     167     229 .. 0.64

  Alignments for each domain:
  == domain 1  score: 44.3 bits;  conditional E-value: 5.8e-15
                 HHHHHHHCCT-T....T-CEEEEETTTS..--..---HCHGHT..CGGSHHH....HHHHHHHHH-SCEEEEEEECTTCE-HHHHHHHHCHT-.SSCHC CS
     FMN_red  18 klaewaaealkea...gaevelidladl.ilpcalcdkdlese..gqtsddv....aellekiaaadaliivtPeYngsysgllKnalDrlsrtrgkke 106
                 klae++ae +  +   +a+v+l ++ +  ++   ++ k          ++++     + ++ + + da+i++tP+ +g++ +++K++lD ++ ++ + e
  EFC36612.1  17 KLAEAIAEGV--SmveNAQVTLKRVPETlPKE--VLEK----MgaLDAQKAMehipIASYDELPQYDAIIFGTPTRFGTMASQMKTFLDATGQIWTNGE 107
                 6777777777..32345666666666664444..2222....122233333333357889*************************************** PP

                 CTT-EEEEEEE-SSTTTTHHHHHHH CS
     FMN_red 107 lrgKpvalvavgggrrgglraeeql 131
                 l gK++ +++ +++++gg+++++  
  EFC36612.1 108 LIGKVGSFFTSSATQHGGQEVTALN 132
                 ******************9987643 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.52
                 T-HHHHHHHHHHCCT-T..T-CEEEE CS
     FMN_red  13 gsntrklaewaaealkea.gaeveli 37 
                 g+ +++++ +a++++++a g +v+ i
  EFC36612.1 172 GGAGERMLSAAEKEIAKAhGKHVTSI 197
                 66778888888888866554444444 PP

>> Flavodoxin_2  Flavodoxin-like fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.5e-07   0.00037       2     126 ..       3     111 ..       2     161 .. 0.67

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.5e-07
                   EEEEEE--TTGGCCHHHCHHHHHHHHHCCCTTTEEEEEEHHCC.T-----CCCCHCCHHHHTT.CHHHHHHHHHHHHCSSEEEEEEE-BTTB--HHH CS
  Flavodoxin_2   2 kiLiinahprpeksfssalaqafvealekagphevtvrdLyad.flpvlttrdlaaklayeek.padveseqiekllaadaivlqfPlwwfgvPail 96 
                   k+Li++ +  +  +   +la+a++e++   + ++vt   + ++ +  vl++  +    +++++ ++   +   ++l + dai++++P  + ++ +++
    EFC36612.1   3 KVLILFYSTYT--HI-FKLAEAIAEGVSMVENAQVTLKRVPETlPKEVLEKMGAL---DAQKAmEHIPIASY-DELPQYDAIIFGTPTRFGTMASQM 92 
                   78888888887..33.699999999999888788999999998888888773222...22222234555666.8*********************** PP

                   HHHHHHHS-TTTSCEETTCSSCCCCTTTTS CS
  Flavodoxin_2  97 KgwiDrvltagfafyteeggegrgggLkgk 126
                   K ++D     g++         + g L gk
    EFC36612.1  93 KTFLDAT---GQIW--------TNGELIGK 111
                   *****75...4433........12344444 PP

>> Flavodoxin_5  Flavodoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.72   1.9e+03       1      24 [.       5      28 ..       5      45 .. 0.72
   2 !   16.4   0.0   3.3e-06    0.0083      34      69 ..      65      99 ..      45     134 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.72
  Flavodoxin_5  1 lilYsSrdGqTkkiaeriaeelre 24
                  lil+ S++ +  k ae+iae ++ 
    EFC36612.1  5 LILFYSTYTHIFKLAEAIAEGVSM 28
                  688889999989999999987763 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 3.3e-06
  Flavodoxin_5 34 vekesedlesydavvigasvyygkllpelakFvekh 69
                  + ++ ++l +yda+++g++ + g + ++++ F+++ 
    EFC36612.1 65 I-ASYDELPQYDAIIFGTPTRFGTMASQMKTFLDAT 99
                  3.3557999***********************9986 PP

>> Flavodoxin_1  Flavodoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0014       3.5       1      45 [.       6      49 ..       6      56 .. 0.82
   2 !    7.7   0.0    0.0015       3.9      32      84 ..      59     107 ..      45     119 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0014
                  EEEETSSSHHHHHHHHHHHHHHHTTTEEEEEEEEGTTSC.GGGGGT CS
  Flavodoxin_1  1 ilYgSetGnteklAkqlaeelgehgfnadvvslsdydes.lseiee 45
                  il++S++ +  klA+++ae+++   ++   v+l+++ e+ ++e+ e
    EFC36612.1  6 ILFYSTYTHIFKLAEAIAEGVSM--VENAQVTLKRVPETlPKEVLE 49
                  89*******************94..455778899999887666655 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0015
                   EEEGTTSC.GGGGGTHSEEEEEEEEETTTBEEGGGHHHHHHHHHHHCHHGCCST CS
  Flavodoxin_1  32 slsdydes.lseieeealllvvtsTfgnGdppengesffqdllelkgdeledgd 84 
                    ++++ ++  +e+++++ ++++t+ +  G +  ++++f ++  +++    ++g+
    EFC36612.1  59 AMEHIPIAsYDELPQYDAIIFGTP-TRFGTMASQMKTFLDATGQIW----TNGE 107
                   46777777778*************.677999999999999988888....3444 PP

>> PTS_IIB  PTS system, Lactose/Cellobiose specific IIB subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00056       1.4      21      64 ..      45      94 ..      42     109 .. 0.81
   2 ?    2.1   0.6      0.13   3.2e+02      18      58 ..     181     224 ..     171     277 .. 0.63

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00056
                HHHHHHCT.EEEEETTEE.GGGHHHHHHT-SEEEEEESSGG....CTHHH CS
     PTS_IIB 21 ekaakelg.ieaegeagv.eleaeeiaddaDlvllapqvrv....kdlar 64
                +++++++g ++a+ +++  ++ ++++  ++D+++ ++ +r+     +++ 
  EFC36612.1 45 KEVLEKMGaLDAQKAMEHiPIASYDELPQYDAIIFGTPTRFgtmaSQMKT 94
                67899999*99999999997777777777***********9555555554 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.13
                 HHHHHHHHHCT.....EEEEETTEEGGGHHHHHHT-SEEEEEESSG CS
     PTS_IIB  18 eklekaakelg.....ieaegeagveleaeeiaddaDlvllapqvr 58 
                  + +++ak++g     i  ++++ ++l+ e +++  ++vl+++  +
  EFC36612.1 181 AAEKEIAKAHGkhvtsIAKKIVEYSPLKMETKSE--QVVLSTTSEQ 224
                 6667888888877555444444444455555444..7777776544 PP

>> PAP1  Transcription factor PAP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   8.5   4.6e-05      0.12      99     189 ..     195     285 ..     164     288 .] 0.60

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.6e-05
        PAP1  99 nsaanegltrgstassaesqsstysansgtstssdSPsssseshqgq..lSScgTSPEPstqSPaakksketsstieeeevahttidgeksfc 189
                 +s a++ + ++  + +++s++ + s+ s++    + P+s s++++    +    T  EPs+q P ++ks ++++  +e++  +++ + e+s c
  EFC36612.1 195 TSIAKKIVEYSPLKMETKSEQVVLSTTSEQP--IAKPTSNSTNNTVVstSTAATTTVEPSKQAPVQEKSSTNTTNAKEQSAVKQEQKKESSCC 285
                 3333333334444444455444454444333..447877776665542245567899***********8888866677766666666555554 PP

>> TCP  TCP family transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   9.0   0.00087       2.2      50     148 ..     178     282 ..     171     285 .. 0.54

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00087
         TCP  50 LLqqaepaikeltgskstgtipa...nftslsislrssgeslskekeea....kllnfeskkkaseekskkekskskkskksskaslseseakesreka 141
                 +L++ae++i ++ g++ t +i +   +++ l+++++s++ +ls+++e++    + ++++++  +++++++++ + sk+  +++k s+++++ake+ + +
  EFC36612.1 178 MLSAAEKEIAKAHGKHVT-SIAKkivEYSPLKMETKSEQVVLSTTSEQPiakpTSNSTNNTVVSTSTAATTTVEPSKQAPVQEKSSTNTTNAKEQSAVK 275
                 799***********6654.34330115666778888888888865555554432222222222222223333333333333445555566666666666 PP

         TCP 142 rerarer 148
                 +e+++e+
  EFC36612.1 276 QEQKKES 282
                 6666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1718  (0.0958224); expected 358.6 (0.02)
Passed bias filter:                      668  (0.0372581); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.41
# Mc/sec: 2120.68
//
Query:       EFC36613.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-33  115.4   0.4    1.8e-33  115.1   0.4    1.1  1  AhpC-TSA       AhpC/TSA family
      1e-21   77.2   0.4    1.5e-21   76.7   0.4    1.1  1  Redoxin        Redoxin
    0.00064   19.8   0.0    0.00088   19.4   0.0    1.2  1  AhpC-TSA_2     AhpC/TSA antioxidant enzyme
     0.0088   16.4   0.2      0.016   15.5   0.2    1.5  1  Thioredoxin_8  Thioredoxin-like


Domain annotation for each model (and alignments):
>> AhpC-TSA  AhpC/TSA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.1   0.4     4e-37   1.8e-33       3     123 ..      33     154 ..      31     155 .. 0.97

  Alignments for each domain:
  == domain 1  score: 115.1 bits;  conditional E-value: 4e-37
                 SB----EEESTTCEEEECHHHTTSEEEEEEESTST-CCHHHHHHHHHHCHHHCCCTTEEEEEEESSSCHHHHHHHHH-H.SSEEEE-TTSHHHHHTT-E CS
    AhpC-TSA   3 dkapdfelknadgetvslsdykgkpvvlffypkdwcpvCttelpalaklyeefkergvevigvsvdspeshkkfiekeslnfpllsDeegkvakaygvl 101
                   apdfe+k++dgetv+ls++k+  vvlffypkd++p+C++e  a++k+ ++f++++++++gvs+ds++shk+f+ek  l+ +l+sD ++++ ++y++ 
  EFC36613.1  33 SIAPDFEVKDQDGETVKLSEIKK-TVVLFFYPKDNTPGCKKENIAFSKYSDKFEKNDIKLLGVSTDSVKSHKSFCEKAALKHTLISDADRDILEKYNAQ 130
                 68*******************98.*************************************************************************** PP

                 ETT..TTECSCEEEEE-TTSBEEE CS
    AhpC-TSA 102 kee..kglalratfvidkegkiry 123
                  ++  ++ a r t+vi k++ki++
  EFC36613.1 131 SKRagSKSARRITYVIGKDMKIVK 154
                 8889999**************985 PP

>> Redoxin  Redoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.7   0.4   3.3e-25   1.5e-21       4     138 ..      33     163 ..      30     172 .. 0.88

  Alignments for each domain:
  == domain 1  score: 76.7 bits;  conditional E-value: 3.3e-25
                 SBB---ECCEETTCEEEEEHHHHTTSEEEEEEESTTT-HHHHHTHHHHHTHHHHHHCSTTTEEEEEESSSHHHHHHHHHTT-TSEEEE-TTSHHHHHTT CS
     Redoxin   4 dkaPdftlplaatdgnsvslsefkgkkvvvnfvpgafcPtCsaehpyleklaellkekgvdvvavvadndafvkefwgkeglkfpvlsDgsaaftkalG 102
                 + aPdf+ ++  +dg++v+lse  +k+vv++f+p   +P C++e +++ k+++++++++++ ++v++d+    k+f++k  lk++++sD++ ++ ++++
  EFC36613.1  33 SIAPDFEVKD--QDGETVKLSEI-KKTVVLFFYPKDNTPGCKKENIAFSKYSDKFEKNDIKLLGVSTDSVKSHKSFCEKAALKHTLISDADRDILEKYN 128
                 557****988..**********5.7999*********************************************************************** PP

                 -TTEEE.GGGEEE-EEEEEEETTEEEEEEESSSCHT CS
     Redoxin 103 lrleedaseglrtpryavidedgkvvylevepepet 138
                 ++ + + s+  + + + vi +d k+v+++  + pet
  EFC36613.1 129 AQSKRAGSK-SARRITYVIGKDMKIVKVYGSVKPET 163
                 995555554.4777788999999****998888854 PP

>> AhpC-TSA_2  AhpC/TSA antioxidant enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0     2e-07   0.00088       3      80 ..      78     156 ..      76     175 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2e-07
  AhpC-TSA_2   3 srdkpeldaagvklvaigigdp.sakkFvkltgfpfelyvDpsaklyqalglkrglklklaplslqkalenllkrlkei 80 
                 s+++++++++ +kl +++ +++ s k+F++    +  l+ D+++++ ++ + +++++++ + ++++ ++ + +k +k  
  EFC36613.1  78 SKYSDKFEKNDIKLLGVSTDSVkSHKSFCEKAALKHTLISDADRDILEKYNAQSKRAGSKSARRITYVIGKDMKIVKVY 156
                 78899*****************88*****************************99999998888888887777777655 PP

>> Thioredoxin_8  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.2   3.5e-06     0.016       2      82 ..      56     131 ..      54     152 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 3.5e-06
                    SEEEEEE--SSSHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-SS-HHHHHHHGGGS-TTSEE.EE-TT-HHHHTT-S--TT CS
  Thioredoxin_8   2 kvvlLyfgaswcppckaftpklkelyeklkkkkkveivyvsldkkeeefekylkknkkpwlsvpfddkkrnklkkkynvka 82 
                    +vvl+++ +++ p ck+ +   +++++k++ k++++++ vs d+  ++ +++++k   +  +   +d +r+ l +kyn ++
     EFC36613.1  56 TVVLFFYPKDNTPGCKKENIAFSKYSDKFE-KNDIKLLGVSTDSV-KSHKSFCEKA--ALKHTLISDADRDIL-EKYNAQS 131
                    34555555778888***************9.7***********95.7777777777..555555555555444.4466655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1173  (0.0654247); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1222.43
//
Query:       EFC36614.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       402  (0.0224218); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 2089.10
//
Query:       EFC36615.1  [L=298]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-49  168.6   0.6    1.4e-49  168.3   0.6    1.1  1  adh_short      short chain dehydrogenase
    8.7e-48  162.9   0.6    1.1e-47  162.6   0.6    1.1  1  adh_short_C2   Enoyl-(Acyl carrier protein) reductase
    8.8e-10   38.8   1.1      1e-09   38.6   0.3    1.5  2  KR             KR domain
    8.6e-05   22.1   0.3    0.00028   20.4   0.3    1.8  1  Epimerase      NAD dependent epimerase/dehydratase family
    0.00066   19.8   0.9     0.0013   18.8   0.9    1.5  1  AdoHcyase_NAD  S-adenosyl-L-homocysteine hydrolase, NAD bindi
    0.00066   19.6   1.8    0.00093   19.1   0.7    1.8  2  3HCDH_N        3-hydroxyacyl-CoA dehydrogenase, NAD binding d


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.3   0.6   4.5e-53   1.4e-49       1     192 [.      45     236 ..      45     239 .. 0.97

  Alignments for each domain:
  == domain 1  score: 168.3 bits;  conditional E-value: 4.5e-53
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHHHHHHHHHHHHHHH.SSESEEEE---SS--SSGGGCSH CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkeegakalaiqvDvtdreevealvekavkkl.gkldvLvnNAGitgsgpfselse 98 
                 kv lvtGa+sGIG+ ia+ +akeG kvvv d + ++++++++ l ++ ++ la+ +Dvt+++ v +++e+++k++ +++dv++ NAG+++  p+ +ls 
  EFC36615.1  45 KVCLVTGAGSGIGKGIAQLFAKEGGKVVVGDLNLAAAQATVAGLDNA-TQHLAVGMDVTKEQVVTETYEAIKKHFgKPIDVVICNAGVQHIDPVDKLSF 142
                 789******************************************95.899************************778********************* PP

                 HHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHHHHHHCT CS
   adh_short  99 eewervievNltgvflltravlpamlkqssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakelaptgirvnavaPGlvdTdmakelre 192
                 ++w+++++v l ++fl+tr++l++m +q+ G+I+ ++Sv++k +++  a+Y ++K++v gl r++ake a++g++ n+++PG+v T++++++ +
  EFC36615.1 143 DNWRKIVSVHLDAAFLCTREALKQMYEQKYGKIIYIGSVHSKLASPLKAPYVSAKHGVLGLCRAVAKEGAKKGVSANVICPGFVLTPLVEKQIP 236
                 ****************************************************************************************998755 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  162.6   0.6   3.7e-51   1.1e-47       1     233 [.      51     295 ..      51     296 .. 0.90

  Alignments for each domain:
  == domain 1  score: 162.6 bits;  conditional E-value: 3.7e-51
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSEEEE--TTSHHHHHHHHHHHHHHH.SSEEEEEE-----EGCSS-GGGH-HHHH CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgaevlecDVtdeeqvealveevvekf.gklDilvnnagiapklkgpfletsreef 95 
                   Ga sgIG++iA+++a+eG +vv+ dln +a +++v+ l +++++ ++ +DVt+e+ v+++ e+++++f + +D+++ nag+ +    p+ ++s +++
    EFC36615.1  51 GAGSGIGKGIAQLFAKEGGKVVVGDLNLAAaQATVAGLDNATQHLAVGMDVTKEQVVTETYEAIKKHFgKPIDVVICNAGVQHI--DPVDKLSFDNW 145
                   889***************************8999999999988889**********************556************9..*********** PP

                   HHHHHHHTHHHHHHHHHHHHHCTSC..CEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTG.GGGSTTHHH.. CS
  adh_short_C2  96 draldvnlyslfllakaalplmkeg..gsivnlssvgaervvpnynaygaaKaalealtrylAvelgpkgiRvNavspgpikTla.asgikgfde.. 187
                   +++++v l ++fl++++al+ m e+  g+i+ + sv+++ + p  + y  aK+++ +l+r++A+e ++kg+  N+++pg++ T++  ++i+++ +  
    EFC36615.1 146 RKIVSVHLDAAFLCTREALKQMYEQkyGKIIYIGSVHSKLASPLKAPYVSAKHGVLGLCRAVAKEGAKKGVSANVICPGFVLTPLvEKQIPEQAKel 242
                   ********************7766669*********************************************************9677788755445 PP

                   ..HHHHHHHHSTTSS-B.....-HHHHHHHHHHHCSGGGTT--SEEEEESTTG CS
  adh_short_C2 188 ..lleelearaplgrlg.....tpeevaeaalfLasdeasyitGqtlvvDgGl 233
                      ++e+ ++++l+ ++     t+++va+a+lf+as+ +++ tGq ++v  G+
    EFC36615.1 243 giSEQEVVKNIMLKDTVdgeftTIDDVAQATLFFASHPTNALTGQSMIVSHGW 295
                   555666777777765432222299*************************9996 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.6   0.3   3.4e-13     1e-09       3     169 ..      47     213 ..      45     223 .. 0.84
   2 ?   -3.2   0.0       2.3   6.8e+03      62     101 ..     244     285 ..     238     289 .. 0.64

  Alignments for each domain:
  == domain 1  score: 38.6 bits;  conditional E-value: 3.4e-13
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE---------TTT- CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvlrdklleem 100
                  l+tG+  g+G+ +a+  a++g + +  ++    + ++++a++a l +   +  +v +Dv++++ v+++ e+ik+++ +pi  vi  Agv + ++++++
  EFC36615.1  47 CLVTGAGSGIGKGIAQLFAKEGGKVV--VGDL--NLAAAQATVAGLDNATQH-LAVGMDVTKEQVVTETYEAIKKHFgKPIDVVICNAGVQHIDPVDKL 140
                 69********************9954..5666..567778899999886555.56789***************************************** PP

                 -HHHHHHHHTTTTHHHHHHH.HHTTT...S--SEEEEEEEHHHHH--TT-HHHHHHHHHHHHHHHHHHHHHHT CS
          KR 101 taedleqvlapKvkGawnLh.elled...esldffvlfSSiagllgsagqanYaaaNaflDalaeyrrsqglp 169
                 + ++++++++  +++a     e+l++   ++   ++++ S+ + l s+ +a Y +a + + +l++  +++g++
  EFC36615.1 141 SFDNWRKIVSVHLDAAFLCTrEALKQmyeQKYGKIIYIGSVHSKLASPLKAPYVSAKHGVLGLCRAVAKEGAK 213
                 ************99986533134444444789999*********************99888888887777765 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.3
                 TT-HHHHHHHH..HHHHHHSS---EEEE---------TTT-- CS
          KR  62 vsdkdaveall..eeikaeeppikGvihaAgvlrdklleemt 101
                 +s+++ v++++  ++++ e+ +i  v +a  +++ ++ + +t
  EFC36615.1 244 ISEQEVVKNIMlkDTVDGEFTTIDDVAQATLFFASHPTNALT 285
                 666666666532245666678888888888887777766666 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.3   9.4e-08   0.00028       2     237 ..      48     288 ..      47     292 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 9.4e-08
                 EEETTTSHHHHHHHHHHHHCTSEEEEEE.S-STTTTCHHCHHC.............EEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHHHSHHH CS
   Epimerase   2 lVtGatGfiGsalvkallekgyevigld.rlssasntarledl.............elveldltdrsalerlfkeeqpdavihlAavggvaassedpad 86 
                 lVtGa   iG+ +++ ++++g +v++ d +l  a++t +   l             +  ++     +a+++ f +  +d+vi  A+v++++   +   d
  EFC36615.1  48 LVTGAGSGIGKGIAQLFAKEGGKVVVGDlNLAAAQATVAG--LdnatqhlavgmdvTKEQVVTETYEAIKKHFGK-PIDVVICNAGVQHIDPVDKLSFD 143
                 9********************9955555145333333333..255889845444444444444444466666664.7899999999****998888888 PP

                 HHHHHTHHHHHHHHHHHHHTCT........EEEEEEEGGGGTSCSSSSBSTCSTTS----SSHHHHHHHHHHHHHHHHHHHHT-EEEEEEESEEESTT. CS
   Epimerase  87 fieknlqgtlnlleaarkagvk........rllflsSsevYGkdaeqpkeettltgplkpnspYaaaKlageklveayaaqyglnaiilrlfnlyGpr. 176
                  ++k + + l+ +  + +  +k        ++++++S  v           ++  +pl    pY  aK+ +  l++a+a+++   a  +   n++ p+ 
  EFC36615.1 144 NWRKIVSVHLDAAFLCTREALKqmyeqkygKIIYIGS--VHS---------KL-ASPL--KAPYVSAKHGVLGLCRAVAKEG---AKKGVSANVICPGf 225
                 8888888888888888777666222222225555555..222.........22.3355..99******************99...56677778888887 PP

                 S-TTSTTSHHHHHHHHHHTTS....SSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT-STTEE CS
   Epimerase 177 ngegevsrvipalirkilegk....qevtllgdgtalRdflyveDvaeaillvlehvdagdkgei 237
                   ++ v++ ip  ++ +   +    +++ l +  t   +f  ++Dva+a l+++ h+ +  +g+ 
  EFC36615.1 226 VLTPLVEKQIPEQAKELGISEqevvKNIMLKD--TVDGEFTTIDDVAQATLFFASHPTNALTGQS 288
                 77777999999888888777633333555555..66669*****************999887765 PP

>> AdoHcyase_NAD  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.9   4.3e-07    0.0013      21     110 ..      42     130 ..      34     154 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 4.3e-07
                    -TTSEEEEE--SH.HHHHHHHHHHHCT-EEEEE-S-HHHHHHHHCTT-EE--HHHCTT...T-SEEEE-SSSSSSB-HHHHCCS-TTEEEEE-S CS
  AdoHcyase_NAD  21 laGkvavvaGyGd.vGkGcaaslkglGarvivtevdPicalqaameGfevvtleevvk...kadivvtttGnkdiitlehlkkmkddaivcniG 110
                    l Gkv++v+G G  +GkG a+ + + G +v+v +++ ++a qa++ G++ +t + +v    + + vvt t   + i+ +h+ k   d+++cn G
     EFC36615.1  42 LEGKVCLVTGAGSgIGKGIAQLFAKEGGKVVVGDLN-LAAAQATVAGLDNATQHLAVGmdvTKEQVVTET--YEAIK-KHFGK-PIDVVICNAG 130
                    67*********9659*******************97.7889***99998766443332101122233333..33333.34443.3345666665 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.7   3.1e-07   0.00093       4      60 ..      49     106 ..      46     125 .. 0.83
   2 ?   -2.2   0.0       1.1   3.2e+03      86     112 ..     249     278 ..     235     286 .. 0.76

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 3.1e-07
                 EE--SC.CHHHHHHHHHHTT-EEEEE-S-HHHHHHHHHHHHHHHHCCTTTTSS-HHHH CS
     3HCDH_N   4 viGaGt.mGagiaavfasagleVvlvdiseealekalekieksleklvekgklkeeev 60 
                 v GaG  +G+gia++fa++g +Vv+ d + +a+++  + + + +++l+    +++e+v
  EFC36615.1  49 VTGAGSgIGKGIAQLFAKEGGKVVVGDLNLAAAQATVAGLDNATQHLAVGMDVTKEQV 106
                 67888669********************************999888877777665554 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.1
                 S-SSHHHHHHH...HHHHHCCS-TTSEEEE CS
     3HCDH_N  86 vvEnlelKrkv...faelekiakpdailas 112
                 vv n+ lK  v   f++++ +a+++ ++as
  EFC36615.1 249 VVKNIMLKDTVdgeFTTIDDVAQATLFFAS 278
                 666777777776668888888888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (298 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       645  (0.0359752); expected 358.6 (0.02)
Passed bias filter:                      525  (0.0292822); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 1965.57
//
Query:       EFC36616.1  [L=378]
Description: DnaJ heat shock family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-37  129.2   1.1    1.9e-37  128.6   1.1    1.3  1  DnaJ_C    DnaJ C terminal domain
    3.3e-21   75.2   9.0    6.5e-21   74.2   6.8    2.4  3  DnaJ      DnaJ domain
  ------ inclusion threshold ------
        8.5    6.5   7.3         22    5.1   1.3    2.6  2  TssO      Type VI secretion system, TssO


Domain annotation for each model (and alignments):
>> DnaJ_C  DnaJ C terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.6   1.1   3.2e-41   1.9e-37       2     148 .]     170     363 ..     169     363 .. 0.91

  Alignments for each domain:
  == domain 1  score: 128.6 bits;  conditional E-value: 3.2e-41
                 EEEEEE-HHHHHH-.EEE.EEEE.................................................TEEEEEE-TT--TT-EEEETT-SSSS. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx..........................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      DnaJ_C   2 eveleisleelykGktkkikikrnvi..........................................kkekktlevkipaGikdgqkirlegeGdeeg 58 
                 +++le++le ly+G   ++k  r+                                            +++ + l+++i++G++dg++i++ geGd+  
  EFC36616.1 170 RIPLEVTLENLYNGRLMNFKRVRTAHegnsqpkkcecrnkvirmmvingvmkrmtennceecknrfdvVQKATALTIQIDRGMRDGEEIIFYGEGDATR 268
                 789***********888887777666999*************************************97777779**********************555 PP

                 ..S---EEEEEEE---SS-EEETTEEEEEEEEEHHHHHHTEEEEEE-S.S-EEEEEE...--TT-EEEETT-S-EET...TEE--EEEEEEEE-- CS
                 .xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      DnaJ_C  59 .gepGDlivtikvkphpvFkrkgndlyveveislaeallGgklevptl.dgkvklki...tqpgevlrikgkGmpklkkpgkrGdlyvevkvefP 148
                   ++GDli+++k k+h++F+r g+dl ++++isl+e l+G +  ++ l d++ ++ki   ++p++++++kg+Gmp++++p +rGdl++e++v fP
  EFC36616.1 269 sHRSGDLIFIVKTKEHSTFTRVGDDLKMKMDISLKESLTGLTKIIKHLdDRNLQIKIdnvIKPNSIRVVKGEGMPRKENPAQRGDLHIEFNVIFP 363
                 5***********99**************************77766777666667765666**********************************9 PP

>> DnaJ  DnaJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.2   6.8   1.1e-24   6.5e-21       1      63 []      47     111 ..      47     111 .. 0.95
   2 ?   -2.5   0.0         1     6e+03      42      58 ..     187     203 ..     186     205 .. 0.77
   3 ?   -0.5   0.0      0.24   1.4e+03      35      50 ..     227     242 ..     223     246 .. 0.82

  Alignments for each domain:
  == domain 1  score: 74.2 bits;  conditional E-value: 1.1e-24
                 HHHHHHTSSTTG-HHHHHHHHHHHHHHHSTTTSCCHH..HHHHHHHHHHHHHHHHTSHHHHHHHH CS
        DnaJ   1 dyYeiLgvskdasedeIkkaYrklalkyHPDknpkdp..eaeekFkeineAyevLsdpekRkqYD 63 
                 d+Ye L v+k+a +d+Ik+a++kl +kyHPD+ ++d   +a++k+ +i++AyevLsd++kR+ YD
  EFC36616.1  47 DLYETLHVPKNAAQDQIKRAFKKLTMKYHPDRYKGDDkaDAQKKYAQISHAYEVLSDEKKRQVYD 111
                 79*****************************8866665799***********************9 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1
                 HHHHHHHHHHHHTSHHH CS
        DnaJ  42 kFkeineAyevLsdpek 58 
                 +Fk++ +A+e  s+p+k
  EFC36616.1 187 NFKRVRTAHEGNSQPKK 203
                 699*****997666665 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.24
                 CHHHHHHHHHHHHHHH CS
        DnaJ  35 kdpeaeekFkeineAy 50 
                 +++e +++F  +++A+
  EFC36616.1 227 NCEECKNRFDVVQKAT 242
                 5678999*******97 PP

>> TssO  Type VI secretion system, TssO
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   1.0      0.01        61       6      32 ..      20      46 ..      17      77 .. 0.79
   2 ?    5.1   1.3    0.0037        22      99     140 ..      81     121 ..      56     122 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.01
        TssO  6 rrsgflyflllFlvtvlllflivffff 32
                rrs+ + f ll+++++++lf++ ++  
  EFC36616.1 20 RRSSSIRFSLLLVLCCCILFIGSCLAA 46
                899999************998877655 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0037
        TssO  99 gknssdeRykmyaqiakfykmlledKkelksvseniklfkkq 140
                 g+++ d   k yaqi   y+ l + Kk+ ++ +  ++ +k+q
  EFC36616.1  81 GDDKADA-QKKYAQISHAYEVLSDEKKRQVYDRYGEEGLKQQ 121
                 5678888.999*****************99988888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1000  (0.0557756); expected 358.6 (0.02)
Passed bias filter:                      629  (0.0350828); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 2097.09
//
Query:       EFC36617.1  [L=423]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.034   14.0   0.0      0.095   12.5   0.0    1.7  1  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   5.3e-06     0.095       2      25 ..     268     291 ..     267     291 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.3e-06
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGs 25 
                 k++   +++s+aL+e+G+V++ G+
  EFC36617.1 268 KQLVGSYFFSIALLENGTVWARGD 291
                 666677899***********9886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (423 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       770  (0.0429472); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2572.12
//
Query:       EFC36618.1  [L=391]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.15   12.3   0.7        1.6    9.0   0.1    2.3  2  Tox-SGS   Salivary glad secreted protein domain toxin
       0.19   12.1   0.2       0.43   10.9   0.2    1.6  1  Orf78     Orf78 (ac78)


Domain annotation for each model (and alignments):
>> Tox-SGS  Salivary glad secreted protein domain toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0     0.053   4.8e+02      18      52 ..      27      63 ..      13      72 .. 0.73
   2 ?    9.0   0.1   0.00018       1.6      55      69 ..     321     335 ..     314     342 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.053
     Tox-SGS 18 eakvkvfskeesle..pteitqdtyskClPlewegqp 52
                 ++ ++f+ +   +    +   d++s+C+  +++g++
  EFC36618.1 27 VGNCNIFPPDDEWNreISNDPVDYMSSCYIAKYSGNL 63
                567788887776653244455688*****99999876 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00018
     Tox-SGS  55 aCeGqetsfiytpye 69 
                 +C+Gq+t++iytp+ 
  EFC36618.1 321 SCNGQSTQLIYTPNY 335
                 8************86 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.2   4.8e-05      0.43      29      82 ..     338     389 ..     327     391 .] 0.60

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 4.8e-05
       Orf78  29 ddndkaenkkekksaaeknditekesnaaekaqalnillisllavvcvlvllyv 82 
                 ++n++  n+ +++++++kn +t+++++a+ +++     +isll+v c  vl+++
  EFC36618.1 338 NNNNNGGNTPTTSTINNKNTTTATSARANGNES--LHSIISLLVVTCATVLVMA 389
                 556666666666666666666666666444444..4455566666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       548  (0.030565); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 2211.53
//
Query:       EFC36619.1  [L=853]
Description: ubiquitin-conjugating enzyme family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.1e-25   86.9   0.1      2e-24   85.8   0.1    1.5  1  UQ_con    Ubiquitin-conjugating enzyme
    2.9e-10   39.4   0.2    0.00084   19.2   0.0    2.9  2  LRR_6     Leucine Rich repeat
    2.8e-06   27.5   4.9    3.2e-06   27.4   1.1    3.2  3  LRR_4     Leucine Rich repeats (2 copies)
    0.00092   18.9   1.3      0.033   13.9   1.3    3.1  1  LRR_8     Leucine rich repeat
     0.0023   18.2   0.5        4.3    8.3   0.0    4.7  2  LRR_1     Leucine Rich Repeat
     0.0026   18.0   0.3        0.1   12.9   0.0    2.9  2  RWD       RWD domain
     0.0092   16.6   2.9        1.2    9.9   0.3    5.2  5  LRR_2     Leucine Rich Repeat
  ------ inclusion threshold ------
       0.28   11.2   3.6       0.42   10.6   1.9    2.3  2  APAF1_C   APAF-1 helical domain


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.8   0.1     9e-28     2e-24      19     132 ..      78     191 ..      60     197 .. 0.83

  Alignments for each domain:
  == domain 1  score: 85.8 bits;  conditional E-value: 9e-28
                 EEEEETTEECEEEEEEEB.TTSTTTTEEEEEEEE--TTTTTS--EEEESST-SCTTBETTSBB-CGGGSTTT--TTSHHHHHHHHHHHHHHS-..-TTS CS
      UQ_con  19 aklvddenlfewkvlikgpedtpYeggvFklelefpedYPlkpPkvkfvtkifHPnvdksGevcldiLkeekWspaltlesvllsiqsLlaep..npes 115
                  ++ d+++++ w+v i g +dt+Y+g vF++ ++f+e+YP+++P++++ t++ HPnv  s ++cld L+ e W+p ++++s+l+++q +l +    ++ 
  EFC36619.1  78 FQVDDERDFMMWHVNIRGNSDTMYDGVVFHAVIKFSENYPMEAPTIRLCTRMEHPNVVDSDRICLDFLE-E-WKPIYSVHSILMQLQTFLYDGadVTRV 174
                 45556799*************************************************************.5.****************99554223333 PP

                 -SSHHHHHHHHHTHHHH CS
      UQ_con 116 plnkeaakllkkdreey 132
                   n++  k +++++eey
  EFC36619.1 175 LSNIQDPKTFEEKKEEY 191
                 34555555555555555 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   3.7e-07   0.00084       3      24 .]     746     767 ..     746     767 .. 0.94
   2 !   17.2   0.1   1.7e-06    0.0038       1      17 [.     775     791 ..     775     797 .. 0.90

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 3.7e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L+ Ld s N+IgD G++ La
  EFC36619.1 746 PSLKILDFSNNKIGDNGVSYLA 767
                 58*****************997 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 1.7e-06
       LRR_6   1 snthLteLdLsgNdIgD 17 
                 ++++Lt+LdLs++dIg 
  EFC36619.1 775 NCPNLTYLDLSHCDIGE 791
                 699************95 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.9   4.3e+03      24      36 ..     483     494 ..     478     511 .. 0.50
   2 !   27.4   1.1   1.4e-09   3.2e-06       1      39 [.     746     789 ..     746     794 .. 0.85
   3 ?   -3.7   0.0         8   1.8e+04      23      33 ..     805     815 ..     796     816 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.9
                 T--EEE-.-S--- CS
       LRR_4  24 nLkeLdLsgNnli 36 
                  LkeL+L +  +i
  EFC36619.1 483 RLKELTL-HIYFI 494
                 5777776.32122 PP

  == domain 2  score: 27.4 bits;  conditional E-value: 1.4e-09
                 SS--EEE--SS---E-S-..HH.......H-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..le.......klpnLkeLdLsgNnlitdl 39 
                 p+L++Ld+snN++ d +   l+       ++pnL++LdLs++    d+
  EFC36619.1 746 PSLKILDFSNNKIGDNGVsyLAdflkklkNCPNLTYLDLSHC----DI 789
                 79*************999773366678857***********9....77 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 8
                 TT--EEE-.-S CS
       LRR_4  23 pnLkeLdLsgN 33 
                 +nLk++  +gN
  EFC36619.1 805 KNLKTFKFTGN 815
                 78888877766 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   1.3   1.5e-05     0.033       5      61 .]     725     789 ..     722     789 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.5e-05
                 EEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G..GG.....GGGGTT--S-.EEE--SS-- CS
       LRR_8   5 sLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt..ls.....pgafsgLpsLrsLdLsgNrL 61 
                 sL+ +++++t+ d ++F+  +++Lk+Ld snN++    +s      + + ++p+L++LdLs++++
  EFC36619.1 725 SLIFHDSKITGSDLSSFYInFPSLKILDFSNNKIGDngVSyladfLKKLKNCPNLTYLDLSHCDI 789
                 67777888888888999866*************9653333222224678999**********997 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.1     0.043        97       1      15 [.     747     761 ..     747     775 .. 0.79
   2 !    8.3   0.0    0.0019       4.3       1      13 [.     778     794 ..     778     804 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.043
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L+ Ld snn +++ 
  EFC36619.1 747 SLKILDFSNNKIGDN 761
                 69********98554 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0019
       LRR_1   1 nLrhLdLsnnpl....l 13 
                 nL++LdLs++ +    +
  EFC36619.1 778 NLTYLDLSHCDIgergT 794
                 8*********9854443 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.0   4.5e-05       0.1      46      81 ..      79     130 ..       3     165 .. 0.66
   2 ?    2.0   0.1      0.11   2.4e+02      70     100 ..     594     650 ..     551     666 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.5e-05
                 .....................TT-CEEEEEEEEE-SSTTSS--EEEEEECCSS- CS
                 x..................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         RWD  46 e..................feekkkpslkleiklpeeYPeeaPiislsstenlp 81 
                 +                  ++  + + ++  ik++e+YP eaP i+l +    +
  EFC36619.1  79 QvdderdfmmwhvnirgnsDTMYDGVVFHAVIKFSENYPMEAPTIRLCTRM--E 130
                 044444444444555555455677899****************99986654..3 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.11
                 -EEEEEECC.......................SS-HHHHHHHHHHHHHHHHHT...T CS
                 xxxxxxxxx.......................xxxxxxxxxxxxxxxxxxxxx...x RF
         RWD  70 Piislsste.......................nlpkeqvksleekleelaeen...l 100
                 P+++ + ++                       +++ + +ks+++ l+e+ae n   l
  EFC36619.1 594 PKLTSEQEWkiacnskwrisklpyylkemkdaWMQLYLQKSMSRTLREMAERNnfiL 650
                 55555555555555566777777777777778899****************885652 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       4.7   1.1e+04       1      15 [.      66      82 ..      66      83 .. 0.75
   2 ?   -0.5   0.0       1.1   2.4e+03       4      19 ..     488     501 ..     487     506 .. 0.74
   3 !    9.9   0.3   0.00054       1.2       6      26 .]     663     684 ..     663     684 .. 0.96
   4 ?    0.4   0.0      0.56   1.3e+03       1      15 [.     747     762 ..     747     765 .. 0.83
   5 ?    0.1   0.0      0.68   1.5e+03       7      20 ..     834     847 ..     833     848 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 4.7
       LRR_2  1 sLKtLhLds.Vrf.sde 15
                +LK++++++ + f  d+
  EFC36619.1 66 NLKIMNIYReMNFqVDD 82
                69***999877777554 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.1
       LRR_2   4 tLhLdsVrfsdedsle 19 
                 tLh++ + ++++  ++
  EFC36619.1 488 TLHIYFIQIFSD--FN 501
                 9******99555..43 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00054
       LRR_2   6 hLdsVrf.sdedslekLLSgCP 26 
                 +L++++f  + d+l+k+LS+ P
  EFC36619.1 663 CLETCWFnGCQDVLTKILSSLP 684
                 69******************88 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.56
       LRR_2   1 sLKtLhLdsVrf.sde 15 
                 sLK+L  +++++ +++
  EFC36619.1 747 SLKILDFSNNKIgDNG 762
                 8**********96665 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.68
       LRR_2   7 LdsVrfsdedslek 20 
                 +++++f++ +++e+
  EFC36619.1 834 IENNIFTGICMFEN 847
                 7999********98 PP

>> APAF1_C  APAF-1 helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         4   8.9e+03      47      64 ..     272     289 ..     268     335 .. 0.64
   2 ?   10.6   1.9   0.00019      0.42       7      98 ..     451     544 ..     445     569 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4
     APAF1_C  47 elkallldldwieakvkl 64 
                 e+++++ +ld +  ++ +
  EFC36619.1 272 EICSIYCSLDILSLRAFM 289
                 678888888877766543 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00019
     APAF1_C   7 klveryekk..ykeeelskldkddlywysyleyHlakanlveelkallldldwieakvkltgpsslledyvkyrkileende.eeledfeeflsv 98 
                 ++++ y++   ++  e +++d+   y ++ + + l++ +l+  + ++++d++ ie+  k++     +  y+ +  ++e+ ++ e+++df++f + 
  EFC36619.1 451 NILKSYKEIadFQCAE-VTDDDRVSYSFKSIRKRLKELTLHIYFIQIFSDFNSIESISKFMNENCGILPYQSIDSFIEKLNQiEKMNDFKTFFKL 544
                 5667777763334443.45667889*************************************************999987777********9864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (853 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       947  (0.0528195); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.79u 0.35s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 4654.76
//
Query:       EFC36620.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1320  (0.0736237); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1375.65
//
Query:       EFC36621.1  [L=1588]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-12   47.5  41.4      8e-05   22.9   9.4    3.7  3  EGF_2     EGF-like domain
    5.5e-11   42.8   5.6    5.5e-11   42.8   5.6    2.1  2  RGS       Regulator of G protein signaling domain
    9.9e-08   32.4   6.1    2.9e-07   30.9   6.1    1.9  1  GPS       GPCR proteolysis site, GPS, motif
  ------ inclusion threshold ------
       0.92    9.9  40.0       0.16   12.3   4.4    3.9  4  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   9.4   1.8e-08     8e-05       4      32 .]     366     394 ..     364     394 .. 0.88
   2 !   22.0   8.7   3.5e-08   0.00016       4      32 .]     405     433 ..     403     433 .. 0.89
   3 !   14.2   7.2   9.7e-06     0.043       6      32 .]     447     472 ..     442     472 .. 0.89

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 1.8e-08
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+g+G C++ + +C+C++g++G++C
  EFC36621.1 366 NsSSVCSGRGECIEMN-KCQCQPGFYGNNC 394
                 55789********666.************* PP

  == domain 2  score: 22.0 bits;  conditional E-value: 3.5e-08
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +  C+g+G+C +++ +C C++gy+G++C
  EFC36621.1 405 NdNRVCSGNGICASSN-NCTCSPGYTGPNC 433
                 44789*******9888.8************ PP

  == domain 3  score: 14.2 bits;  conditional E-value: 9.7e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C ++   C C  gy G +C
  EFC36621.1 447 NVCSGNGNCLQPD-FCTCTGGYLGIDC 472
                 78********888.9************ PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       2.5   1.1e+04      32      60 ..    1306    1334 ..    1294    1340 .. 0.66
   2 !   42.8   5.6   1.2e-14   5.5e-11       2     112 ..    1426    1565 ..    1425    1570 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.5
                  HHHHHHHTSSHHHHHHHHHHHHHHHHTST CS
         RGS   32 laveefkkakeqeelkkkakeIyneylap 60  
                  +a ++f+k++ ++  k  +k+ y+ +++ 
  EFC36621.1 1306 EALQKFDKETAKKMAKVPIKRAYDWFIQL 1334
                  46788888845554455588888888865 PP

  == domain 2  score: 42.8 bits;  conditional E-value: 1.2e-14
                  HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS....SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS........... CS
         RGS    2 leslledqpgrslFreFlesefseenlsFwlaveefkka....keqeelkkkakeIyneylapsspkelnidkklreelekrleke........... 83  
                  le+ll++  g++lF++F+++e+s enl+++l+ +++++     +  +++++ ++e++ +y++++s ke+ni++++r+e ++  +             
  EFC36621.1 1426 LEQLLSNREGLKLFESFCKKEYSLENLHLYLELKQLQELikanDRIDSVNSLIEELFTNYIESGSIKEVNIPSETRNEFKQMRKSLselvnsaknnq 1522
                  89*********************************99998888999999999**************************9987666578888888887 PP

                  ...............STTTTTTHHHHHHHHHHHHHHHHHHHHTS CS
         RGS   84 ...............qpsrklfeeaqeevfellekdsypkFlks 112 
                                 ++ ++    +q+++   l +d +++F ++
  EFC36621.1 1523 emksknekeipeafhEKLQQSISSLQDQIIINL-NDTFSRFTTT 1565
                  777777755555555555555555555555555.3556666665 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   6.1   6.6e-11   2.9e-07       2      43 ..     984    1022 ..     983    1024 .. 0.93

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 6.6e-11
         GPS    2 sCvfWdeeneetgsWsteGCeltesdnknetvCsCnHLtsFA 43  
                  +C fW   ne+t +W+++GC+l + +++   +C+C+H+t FA
  EFC36621.1  984 TCKFW---NETTLQWDSSGCSLSTLQSNGDLICKCTHTTLFA 1022
                  8****...7899*********988889999***********9 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   4.4   3.7e-05      0.16       6      32 .]     371     393 ..     364     393 .. 0.85
   2 ?   12.1   7.7   4.2e-05      0.19       2      32 .]     405     432 ..     405     432 .. 0.89
   3 ?    2.6   6.0     0.038   1.7e+02       3      28 ..     446     467 ..     444     471 .. 0.85
   4 ?   -2.7   0.3       1.8   8.1e+03      17      25 ..    1008    1016 ..     998    1017 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.7e-05
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs++G+C++      +C+C++G+ G++
  EFC36621.1 371 CSGRGECIEMN----KCQCQPGFYGNN 393
                 *******7777....**********86 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 4.2e-05
                 CSTT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   2 spnp.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 ++n+ Cs++G+C      + +C+C++GytG++
  EFC36621.1 405 NDNRvCSGNGIC----ASSNNCTCSPGYTGPN 432
                 57889*******....6888**********86 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.038
                 STTSTTT-EEEEETTTEEEEEECTTE CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGy 28 
                 pn Cs++G C+++      C+C+ Gy
  EFC36621.1 446 PNVCSGNGNCLQPD----FCTCTGGY 467
                 577*******9999....****9888 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 1.8
                  TTEEEEEEC CS
         EGF   17 rggytCiCp 25  
                  +g+ +C+C+
  EFC36621.1 1008 NGDLICKCT 1016
                  67779***7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1588 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1830  (0.102069); expected 358.6 (0.02)
Passed bias filter:                      596  (0.0332422); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.15u 0.30s 00:00:01.45 Elapsed: 00:00:00.52
# Mc/sec: 9144.64
//
Query:       EFC36622.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.055   13.6   1.0        0.1   12.7   1.0    1.4  1  DGC       DGC domain
      0.077   12.6   0.0        0.6    9.7   0.0    2.2  1  Ras       Ras family
      0.092   12.8   0.0        0.2   11.7   0.0    1.6  1  MMR_HSR1  50S ribosome-binding GTPase


Domain annotation for each model (and alignments):
>> DGC  DGC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   1.0   1.7e-05       0.1      41      80 ..     154     193 ..     132     211 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.7e-05
         DGC  41 eelvelaksarkiiaidGCpleCakkilekagvkpdehlv 80 
                 e+++e+    +  i+idGC   C+ +++   + k+ ++++
  EFC36622.1 154 EGMMEKESLFEANIMIDGCMIMCTMQCMSLSNEKIVQEVI 193
                 3444444445568****************99999999986 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0    0.0001       0.6       4      45 ..     131     171 ..     128     296 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0001
                 EEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETT CS
         Ras   4 lvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdg 45 
                 +vG    GK+sll+ + ++ F ee  +   +  ++++i++dg
  EFC36622.1 131 IVGLPKSGKSSLLCTYCTNFFAEEGMMEK-ESLFEANIMIDG 171
                 7999999**************99977666.666666666664 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   3.4e-05       0.2       1      21 [.     128     148 ..     128     164 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.4e-05
                 EEEEEESTTSSHHHHHHHHHT CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltg 21 
                 +++ivG p +GKS+L+ + + 
  EFC36622.1 128 NIGIVGLPKSGKSSLLCTYCT 148
                 599************977665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       751  (0.0418874); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 2013.54
//
Query:       EFC36623.1  [L=492]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.9e-73  246.0   0.1    7.9e-73  245.3   0.1    1.3  1  tRNA-synt_1b  tRNA synthetases class I (W and Y)
    0.00036   20.2   0.0    0.00073   19.2   0.0    1.5  1  S4            S4 domain
  ------ inclusion threshold ------
       0.19   11.9   0.9       0.54   10.5   0.9    1.7  1  Gal4_dimer    Gal4-like dimerisation domain


Domain annotation for each model (and alignments):
>> tRNA-synt_1b  tRNA synthetases class I (W and Y)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  245.3   0.1   1.3e-76   7.9e-73       4     292 ..      77     384 ..      74     385 .. 0.95

  Alignments for each domain:
  == domain 1  score: 245.3 bits;  conditional E-value: 1.3e-76
                   S--EEEEEEETSSS.-BGGGHHHHHHHHHHHH....TTSEEEEEEEHHHHHTTTTT.-SSHHHHHHHHHHHHHH...HHHHHHHTCHTTTEEEEETH CS
  tRNA-synt_1b   4 rplrvysGidPTgk.lHlGylvplkklvelqk....aghevffliaDlhAiigdps.kaeerklrkreevlena...ikaqlakgldpekaevvlqs 91 
                   + + +y+G+dPT++ lH+G+l++l++l ++q     ++++++ l++++++ igdps +++er l+++++  +n+    +++ + + + ++++vv++ 
    EFC36623.1  77 KSIGIYAGFDPTASgLHVGNLLVLQTLKRFQLafnpKNVHIYCLVGGATGRIGDPSgRKTERPLLDESTINNNIeglKREMNSFFSSKNNVTVVNNA 173
                   5789****************************9999*************************************999556666666777779****** PP

                   HHHTTHHHHHHHHHHHTTCBHHHHHHHHHCCHHCSS.S...C--BHHHHHHHHHHHHHHHHTCHS....EEEEEGGGHHHHHHHHHHHHHHHHH... CS
  tRNA-synt_1b  92 ewlehlelaellrdlgklgslnrmlqfksvkkrlee.g...egislgeftYplLqaaDilllkad....lvpgGsDQkqnielgrdlarrfnkk... 177
                   +wl ++++++llr++gk ++++ ml+ +svk+r+e+ +    g++++ef+Y l q++D+++l       l++gGsDQ++ni++g + +++ +     
    EFC36623.1 174 DWLGEMKMIDLLRNVGKYFQIANMLRLDSVKSRVENaDadnGGMTFTEFSYSLFQSYDFFHLLNSnnvrLQIGGSDQWGNITSGLEFIKKKQTAmpe 270
                   ************************************6699999*****************986666999**********************9999*9 PP

                   STTSS-EEEEET-BBSTTSSSBTTCETTCGC-BTTCCHHHHHHHHHHCHCSTTCSHHHHHHHHHTHHHCHHHHHHHHCCSEE.ESSHHHHHHHHHCC CS
  tRNA-synt_1b 178 evfkkpegltvplltgldGekKmSKSagnsaIfLddekesvkkkiqkavtdsdeevekllklktelsnelierleavsgkkp.kreaeellaeevtk 273
                   ++   ++g+t pllt +dG  K++KS gn a++L++e +sv +++q++++ +d++vekllk++t++s e i+++ ++++++p kr a++ laee t 
    EFC36623.1 271 SCQSVCSGMTIPLLTTADGV-KFGKSMGN-AVWLNPEMTSVFDFYQYFLRVQDADVEKLLKMLTFVSLEDIDQILQEHNQQPeKRIAQQRLAEELTT 365
                   999*****************.********.******************************************************************* PP

                   CCHHHHHHHHHHHHHHHHH CS
  tRNA-synt_1b 274 lvhggdlkkalaealnell 292
                   ++hg++  +++++ +n l+
    EFC36623.1 366 QIHGKEQLEKVQKCTNLLF 384
                   *************999888 PP

>> S4  S4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   1.2e-07   0.00073       4      46 ..     427     468 ..     426     470 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 1.2e-07
                 HHHHHHTTSSSSHHHHHHHHHTTTEEETTEEE--TT-EE-TTC CS
          S4   4 dkvlarlglassrreArqlIehGrVlVNGkvvkdpsyrVkpgD 46 
                 d+ la l+l++s++e  +lI+ G++++N k+  dp+y  ++ D
  EFC36623.1 427 DIALA-LKLGPSKSELGKLIKSGGFYINYKRQIDPKYVMTEAD 468
                 77888.*************************999999766655 PP

>> Gal4_dimer  Gal4-like dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.9     9e-05      0.54      15      45 ..     324     356 ..     318     362 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 9e-05
  Gal4_dimer  15 LEqlLrrl.lpe.eDiDnlLknkhnnflkeilt 45 
                  E+lL+ l ++  eDiD++L++++++  k i +
  EFC36623.1 324 VEKLLKMLtFVSlEDIDQILQEHNQQPEKRIAQ 356
                 7999998745558**********9998888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (492 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       872  (0.0486363); expected 358.6 (0.02)
Passed bias filter:                      586  (0.0326845); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 3032.39
//
Query:       EFC36624.1  [L=475]
Description: Hypothetical protein NAEGRDRAFT_82183 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      1e-07   32.7   1.6    3.4e-06   27.7   0.2    2.4  2  DUF1963     Domain of unknown function (DUF1963)
    0.00027   20.8   0.1     0.0006   19.7   0.1    1.5  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.069   13.1   0.2       0.16   11.9   0.2    1.7  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> DUF1963  Domain of unknown function (DUF1963)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.1   0.00083         5     105     152 ..     222     282 ..     161     289 .. 0.54
   2 !   27.7   0.2   5.8e-10   3.4e-06       2     101 ..     272     377 ..     271     467 .. 0.62

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00083
                 THHHHHTS-HHHHHHGGGG.............GHHHHHHHHHHT..--SSEEES----SS- CS
     DUF1963 105 rfeellleeleeeeeeeae.............eleeeyleeyeeeseeghklgGypeftqe 152
                 + ++ + ++++++e+ +++             +l+ +y+++++ ++++++k+gG p++t++
  EFC36624.1 222 NSKKSIISSFMKSESVDNSseeilnnavslsyNLYPDYFDSNKPNDGSKTKIGGSPNTTNK 282
                 2222222222222222222444444555666678899********************9975 PP

  == domain 2  score: 27.7 bits;  conditional E-value: 5.8e-10
                 EESS----BTTS---B-TTS-B-EEEEEEEGGGS---TTS..-SS-EEEEEE.-SSSSSTT--SS-.--SSEEEEEESS----.-SB.......-S-EE CS
     DUF1963   2 klGGlPylpkgaewPtdedgeplsflaQiNlaelpaledf..PekGlLqfFidleeedlygldped.sqegfrviYledveed.fpl.......edefk 89 
                 k+GG P  +++ ++ ++     + f+ Q++++el +l ++  P++G L+fF+++ e+    l+ ++ ++ +  v+Y +  +++ +pl       ++ +k
  EFC36624.1 272 KIGGSPNTTNKSAIWRK----GYVFVGQLDCSELGSLINYqiPKSGFLYFFVKM-ENIRVELNEAKiDAIDGYVVYQDYKDNStVPLaqldgseSQVVK 365
                 88999988877776443....389************656679**********87.44456666666767777788866555544455555554422223 PP

                 EEEEEEEE---T CS
     DUF1963  90 lsfeleeekisl 101
                 l+ ++ +  is+
  EFC36624.1 366 LHNHSLKLGISA 377
                 333222222222 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.1     1e-07    0.0006       7      43 ..     139     176 ..     138     180 .. 0.90

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 1e-07
  F-box-like   7 EiLlqIFsyL.ppsdLlrlalVCrrWrrvaldtplLWr 43 
                 ++ + I+ ++ ++++Llr + VC++W+ ++  + ++W+
  EFC36624.1 139 DVHSNILKFIgNFNELLRMRIVCKYWNCLIVENDEIWK 176
                 677899***999******************9999***8 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.2   2.6e-05      0.16       2      38 ..     132     169 ..     131     179 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.6e-05
                 HHHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHT CS
       F-box   2 tlsrLPsevlrhILerLplsd.llalrrVSkgwrilid 38 
                 +ls L ++v  +IL++ +    ll++r V+k w+ li 
  EFC36624.1 132 SLSALVPDVHSNILKFIGNFNeLLRMRIVCKYWNCLIV 169
                 5788899999999999999999***********99885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       535  (0.0298399); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 3006.58
//
Query:       EFC36625.1  [L=77]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-32  111.5   0.9    1.3e-32  111.4   0.9    1.0  1  ubiquitin    Ubiquitin family
    8.1e-16   57.6   0.9    8.9e-16   57.5   0.9    1.0  1  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
    1.3e-05   25.3   0.1    3.4e-05   23.9   0.1    1.7  1  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
    2.9e-05   24.4   0.4    9.4e-05   22.8   0.4    1.7  1  Ubiquitin_2  Ubiquitin-like domain
    0.00028   21.4   0.1    0.00031   21.3   0.1    1.1  1  DUF2407      DUF2407 ubiquitin-like domain
    0.00032   20.6   0.1    0.00034   20.5   0.1    1.1  1  TBK1_ULD     TANK binding kinase 1 ubiquitin-like domain
     0.0018   18.6   0.1     0.0021   18.4   0.1    1.1  1  Ubiquitin_5  Ubiquitin-like domain
      0.004   17.2   0.4       0.38   10.8   0.1    2.0  2  Ubiquitin_4  Ubiquitin-like domain
  ------ inclusion threshold ------
      0.087   13.0   0.3       0.18   12.0   0.2    1.7  2  PI3K_rbd     PI3-kinase family, ras-binding domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.4   0.9   6.4e-36   1.3e-32       1      72 []       3      74 ..       3      74 .. 0.99

  Alignments for each domain:
  == domain 1  score: 111.4 bits;  conditional E-value: 6.4e-36
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                ++vktl+gk+it+e+e++dtve+lK+ki +kegip +qqrLiy+Gk+Led rt+++y++q++st+hlvlrlr
  EFC36625.1  3 LFVKTLTGKTITIEMESNDTVEHLKQKIFDKEGIPSDQQRLIYAGKQLEDGRTVSDYNLQKDSTVHLVLRLR 74
                79*******************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.5   0.9   4.5e-19   8.9e-16       1      72 []       1      71 [.       1      71 [. 0.98

  Alignments for each domain:
  == domain 1  score: 57.5 bits;  conditional E-value: 4.5e-19
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                +++++k+ +gk+++i+ +++ tv++L+++  +k+gip  +++rLi+ G++L++  tv d+ +++++t+++v+
  EFC36625.1  1 MQLFVKTLTGKTITIEMESNDTVEHLKQKIFDKEGIPS-DQQRLIYAGKQLEDGRTVSDYNLQKDSTVHLVL 71
                89************************************.******************************996 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.1   1.7e-08   3.4e-05      11      87 ..       9      71 ..       1      74 [. 0.76

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1.7e-08
                 TS-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2 11 dGsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87
                  G+ +  +++++++tv++lk+k++++     e  p++    +li+aGk Le+ +t+++++l+         ++H+v+
   EFC36625.1  9 TGK-TITIEMESNDTVEHLKQKIFDK-----EGIPSDQ--QRLIYAGKQLEDGRTVSDYNLQKDS------TVHLVL 71
                 677.7778999*************74.....4455544..48****************9665433......466665 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.4   4.7e-08   9.4e-05      14      79 ..      11      68 ..       2      70 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 4.7e-08
                 SEEEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2 14 vsserrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79
                 +  ++ +++++t+e+lK+k+    G++ +++rL +          k  +d +++++Y+++  +++h
   EFC36625.1 11 KTITIEMESNDTVEHLKQKIFDKEGIPSDQQRLIYA--------GKQLEDGRTVSDYNLQKDSTVH 68
                 567789999************************997........4445677777777777777777 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.1   1.5e-07   0.00031      16      64 ..      13      59 ..       4      72 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 1.5e-07
     DUF2407 16 LdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslass 64
                ++i+  ++ tv+ Lkq i ++    + s + rLIyaG+ Led  ++++ 
  EFC36625.1 13 ITIEMESNDTVEHLKQKIFDKE--GIPSDQQRLIYAGKQLEDGRTVSDY 59
                678888999***********98..88888889***********999875 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   1.7e-07   0.00034      15      55 ..      13      51 ..       4      71 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.7e-07
    TBK1_ULD 15 hkiYihpyntvaifqeevakqTkiaaekQellfeghrllle 55
                ++i +++++tv+ + ++++++  i++++Q l++ g++l  e
  EFC36625.1 13 ITIEMESNDTVEHLKQKIFDKEGIPSDQQRLIYAGKQL--E 51
                6677899*****************************87..3 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.1   1.1e-06    0.0021      33      93 ..      12      73 ..       4      76 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.1e-06
  Ubiquitin_5 33 kklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93
                   ++e++ + t+++l +ki ++ g+  ++ +li+ gk+le ++t  + +++++s v +vL+l
   EFC36625.1 12 TITIEMESNDTVEHLKQKIFDKEGIPSDQQRLIYAGKQLEDGRTVSDYNLQKDSTVhLVLRL 73
                 5567777788999**************************************99998677776 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.1   0.00019      0.38       1      31 [.       1      31 [.       1      42 [. 0.91
   2 !    5.3   0.0    0.0099        20      58      86 ..      43      70 ..      39      73 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00019
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaie 31
                 +++ vk l g+++ +++++n tv+ Lk+ i 
   EFC36625.1  1 MQLFVKTLTGKTITIEMESNDTVEHLKQKIF 31
                 7899***********************9985 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0099
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L++ g++L+ d  ++++y ++++s+++ v
   EFC36625.1 43 LIYAGKQLE-DGRTVSDYNLQKDSTVHLV 70
                 889999986.66789*********99876 PP

>> PI3K_rbd  PI3-kinase family, ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.2   8.8e-05      0.18      27      52 ..       9      36 ..       1      63 [. 0.78
   2 ?   -0.8   0.0      0.85   1.7e+03      91     103 ..      60      72 ..      54      74 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 8.8e-05
                -SEEEEEEEETTS-HHHHHHHHHHC..H CS
    PI3K_rbd 27 kqqkvtlkvnpnstpesllaealrk..k 52
                + +++t++++ n+t+e l+++++ k   
  EFC36625.1  9 TGKTITIEMESNDTVEHLKQKIFDKegI 36
                5689*******************99552 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.85
                 HHHCT--EEEEEE CS
    PI3K_rbd  91 clksgrephLvLv 103
                  l++++++hLvL+
  EFC36625.1  60 NLQKDSTVHLVLR 72 
                 5677888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (77 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       675  (0.0376485); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 528.52
//
Query:       EFC36626.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-16   58.8   0.1    8.2e-16   57.6   0.1    1.7  1  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.6   0.1   4.6e-20   8.2e-16       1      70 []      48     118 ..      48     118 .. 0.98

  Alignments for each domain:
  == domain 1  score: 57.6 bits;  conditional E-value: 4.6e-20
                 EEEESETTTSSHHHHHHHHHTTSCEEEEEEEEE.TTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEEE CS
       RRM_1   1 lfVgnLppdvteeeLkelFskfGpiksiklvrd.etgkskgfafVeFeskedAekAlealngkklggrelk 70 
                 ++V+nL+++++ee+++elF+k+G++k++ +  + +t ++ gf+fVeF  ++dAe++++ + g kl++r lk
  EFC36626.1  48 IYVENLSFYTKEEQIYELFEKCGEVKRVVMGLNrNTLTPCGFCFVEFYHRSDAEECVKYCRGCKLNNRALK 118
                 8*******************************************************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      301  (0.0167884); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 2255.60
//
Query:       EFC36627.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.7e-17   62.4   8.6     0.0011   19.7   0.2    6.9  7  WD40         WD domain, G-beta repeat
    2.5e-12   46.9   1.1    0.00096   19.4   0.0    4.2  4  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
     0.0033   16.3   1.3       0.38    9.5   0.0    3.1  3  DPPIV_N      Dipeptidyl peptidase IV (DPP IV) N-terminal regi
     0.0076   15.3   1.5       0.95    8.4   0.4    3.5  2  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
  ------ inclusion threshold ------
      0.011   15.6   7.1      0.083   12.8   0.8    3.7  4  eIF2A        Eukaryotic translation initiation factor eIF2A


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.053   1.9e+02      12      37 ..      13      38 ..       4      39 .. 0.78
   2 !   19.7   0.2   3.1e-07    0.0011       4      37 ..      52      86 ..      49      87 .. 0.90
   3 ?    4.2   0.0     0.026        92      14      30 ..     109     125 ..     104     131 .. 0.86
   4 !    9.4   0.0   0.00056         2       8      34 ..     147     174 ..     141     178 .. 0.82
   5 !   17.6   0.2   1.5e-06    0.0053      11      35 ..     207     231 ..     197     234 .. 0.82
   6 ?   -2.4   0.0         3   1.1e+04      18      31 ..     265     277 ..     249     278 .. 0.80
   7 !    6.9   0.0    0.0034        12      10      38 .]     339     371 ..     334     371 .. 0.62

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.053
                SEEEEEEETTSSEEEEE.ETTSEEEEE CS
        WD40 12 svtslafspdgawlasG.sdDgtvriW 37
                 ++++a++ d++ +a + + +  ++i+
  EFC36627.1 13 AISCMAWNGDKSRVAVSpG-NSEIHIY 38
                499**********987668.8888876 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 3.1e-07
                EEEEESSSS.EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  4 lrtltGHss.vtslafspdgawlasGsdDgtvriW 37
                 +tlt H++ vt++++ p ++ ++s+  D++ ++W
  EFC36627.1 52 EHTLTDHDHyVTGIDWAPKSNKILSCAQDRNAYVW 86
                699****667************************* PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.026
                 EEEEEETTSSEEEEEET CS
        WD40  14 tslafspdgawlasGsd 30 
                 t++++sp+   +a Gs 
  EFC36627.1 109 TCCKWSPNEEKFAVGSA 125
                 8**********999985 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.00056
                 ESS.SSEEEEEEETTSSEEEEEETTSEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtv 34 
                 + H s + s+a++p  + la+Gs D + 
  EFC36627.1 147 KKHkSTIKSVAWHPTINTLATGSSDMKA 174
                 569666****************889765 PP

  == domain 5  score: 17.6 bits;  conditional E-value: 1.5e-06
                 SSEEEEEEETTSSEEE.EEETTSEEE CS
        WD40  11 ssvtslafspdgawla.sGsdDgtvr 35 
                 ++v+s++fsp+g+wla  G+ D tv 
  EFC36627.1 207 GWVHSVQFSPNGKWLAfIGH-DSTVQ 231
                 45************9779**.**996 PP

  == domain 6  score: -2.4 bits;  conditional E-value: 3
                 EETTSSEEEEEETT CS
        WD40  18 fspdgawlasGsdD 31 
                 f +d+ ++a+G  D
  EFC36627.1 265 FLSDKVFVAAGY-D 277
                 677888998887.6 PP

  == domain 7  score: 6.9 bits;  conditional E-value: 0.0034
                 SSSEEEEE.....EETTSSEEEEEETTSEEEEEE CS
        WD40  10 Hssvtsla.....fspdgawlasGsdDgtvriWd 38 
                 H+ ++++        + ++++++G  Dg+v +W+
  EFC36627.1 339 HNVINCIEafkveGGKVSKFVTAGL-DGKVLFWN 371
                 4446777664444444445565555.*******8 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   0.1   7.2e-05      0.26      37      89 ..      10      67 ..       2      70 .. 0.79
   2 ?    1.5   0.0       0.1   3.6e+02      35      59 ..      56      80 ..      47      95 .. 0.69
   3 !   19.4   0.0   2.7e-07   0.00096       2      73 ..     112     185 ..     111     199 .. 0.89
   4 !   11.2   0.0   9.4e-05      0.34      36      70 ..     204     238 ..     192     253 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 7.2e-05
  ANAPC4_WD40 37 edsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksek.....avtclgW 89
                   + ++++aW+ d +  av+  ++e+++++ +  +  ++++ +++       vt ++W
   EFC36627.1 10 LAQAISCMAWNGDKSRVAVSPGNSEIHIYKTNGSEDFEKWEREHTLtdhdhYVTGIDW 67
                 56789************************99988888777766665555556777777 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.1
  ANAPC4_WD40 35 dkedsevrsLaWkpdgklLavaysd 59
                 +++d+ v+++ W p+ + +    +d
   EFC36627.1 56 TDHDHYVTGIDWAPKSNKILSCAQD 80
                 678999******9986655544444 PP

  == domain 3  score: 19.4 bits;  conditional E-value: 2.7e-07
  ANAPC4_WD40   2 swcptmDLiAlatedgellvfRlngqrvwtl..eedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvv 73 
                  +w+p+ + +A++++++ ++v+  + ++ w +    +k++s+++s+aW+p  + La + sd + r ++ + ++v 
   EFC36627.1 112 KWSPNEEKFAVGSASKMIAVCFYEAENKWYIskMIKKHKSTIKSVAWHPTINTLATGSSDMKARTFNTYLKEVD 185
                  8**************************99997666899**************************9999987765 PP

  == domain 4  score: 11.2 bits;  conditional E-value: 9.4e-05
  ANAPC4_WD40  36 kedsevrsLaWkpdgklLavaysdgevrlldaesg 70 
                  ++++ v+s++++p+gk La+  +d++v+++d  s+
   EFC36627.1 204 TSKGWVHSVQFSPNGKWLAFIGHDSTVQFVDYASQ 238
                  567889***********************997664 PP

>> DPPIV_N  Dipeptidyl peptidase IV (DPP IV) N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0    0.0001      0.38     161     207 ..      36      83 ..      27      94 .. 0.84
   2 ?   -0.2   0.0     0.093   3.3e+02      42      59 ..     105     122 ..      82     128 .. 0.67
   3 !    3.1   0.0     0.009        32      47     120 ..     211     226 ..     194     243 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.0001
                 EEEECTTSCEE.ECS-HHHHCTTCEEEEEEEECTTSCCEEEEEEETTS CS
     DPPIV_N 161 kvvdlasgktv.evqlpdslsekdeyitrvkWtsdeksllvqwlnRsq 207
                 +++++++ + + +++  + l + d+y+t ++W+++++++l+  ++R+ 
  EFC36627.1  36 HIYKTNGSEDFeKWEREHTLTDHDHYVTGIDWAPKSNKILSCAQDRNA 83 
                 566665555556888889999***********************9986 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.093
                 TT.BSEEEEESSTTEEEE CS
     DPPIV_N  42 eeklqlakwSPagdklaf 59 
                 +++++ +kwSP+ +k+a+
  EFC36627.1 105 TKAATCCKWSPNEEKFAV 122
                 677788888888888875 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.009
                 EEEEESSTTEEEEEETTEEEEESTTTSEEEECES-STTTEEESB--HHHHHHTSSSSBEEEE-TTSSEEEEEEE CS
     DPPIV_N  47 lakwSPagdklafvrnnnLyvrelatgkeiqlTsdgsagifnGvadWvyeEEvlgsnsavwWspdgsrlaylrf 120
                  +++SP+g++laf                                                          +  
  EFC36627.1 211 SVQFSPNGKWLAF----------------------------------------------------------IGH 226
                 4455555555555..........................................................544 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.4   0.00026      0.95     161     215 ..     171     234 ..      47     270 .. 0.57
   2 ?   -0.5   0.0      0.13   4.6e+02     194     217 ..     347     373 ..     309     378 .. 0.64

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00026
    Ge1_WD40 161 dmiaskygs.......gelsveeieegllkieehs..liveaafspdGtalatasedGevkffq 215
                 dm a+ +++       +    ++++ g + +e +s   + +  fsp+G  la   +d +v+f  
  EFC36627.1 171 DMKARTFNTylkevdgKRSADNKLKFGDVFVEYTSkgWVHSVQFSPNGKWLAFIGHDSTVQFVD 234
                 3333333332211110222333444444444444422588888888888888888888888865 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.13
    Ge1_WD40 194 afspdGtal...atasedGevkffqvy 217
                 af  +G  +    ta  dG+v f+ v 
  EFC36627.1 347 AFKVEGGKVskfVTAGLDGKVLFWNVA 373
                 55555554411168999******9985 PP

>> eIF2A  Eukaryotic translation initiation factor eIF2A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0      0.04   1.4e+02      61      93 ..      13      43 ..       4      78 .. 0.71
   2 ?   12.8   0.8   2.3e-05     0.083      48     116 ..      94     166 ..      67     170 .. 0.71
   3 ?    0.2   0.0      0.17     6e+02      53      77 ..     200     224 ..     192     250 .. 0.75
   4 ?   -2.8   0.0       1.4     5e+03     122     134 ..     362     374 ..     338     377 .. 0.66

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.04
                .EEEEEE-TTSS-EEEEESSSSCEEEEEECSCE CS
       eIF2A 61 pihdvaWspkskefaviyGkmpakvslfdlkvk 93
                 i ++aW+ ++++ av  G++  ++++++++++
  EFC36627.1 13 AISCMAWNGDKSRVAVSPGNS--EIHIYKTNGS 43
                488999999999999998865..5667776643 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 2.3e-05
                 T--EEECCEESSS.EEEEEE-TTSS-EEEEESSSSCEEEEEECS....CEEEEEEEEES--EEEE-TTSSEEE CS
       eIF2A  48 kkksevvelkkegpihdvaWspkskefaviyGkmpakvslfdlk....vkviskleeqkrNtiffspkgklvl 116
                 k +   v l+ +  + + +Wsp++++fav        v +++ +    ++++ k +++   ++ ++p+ + ++
  EFC36627.1  94 KWNPTLVLLRLTKAATCCKWSPNEEKFAVGSASKMIAVCFYEAEnkwyISKMIKKHKSTIKSVAWHPTINTLA 166
                 4444556666666799*************98888889*****9644444555555555555667888766665 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.17
                 ECCEESSS.EEEEEE-TTSS-EEEE CS
       eIF2A  53 vvelkkegpihdvaWspkskefavi 77 
                  ve + +g +h v+ sp++k +a i
  EFC36627.1 200 FVEYTSKGWVHSVQFSPNGKWLAFI 224
                 5777888889999999998877666 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 1.4
                 SSS-EEEEEETTT CS
       eIF2A 122 nlaGeleiwdvkk 134
                  l G++ +w+v +
  EFC36627.1 362 GLDGKVLFWNVAD 374
                 3567777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       560  (0.0312343); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 2412.87
//
Query:       EFC36628.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.5e-07   31.3   5.3      0.016   16.1   0.3    5.2  6  WD40          WD domain, G-beta repeat
    1.2e-05   25.5   0.0       0.45   10.8   0.0    3.6  3  ANAPC4_WD40   Anaphase-promoting complex subunit 4 WD40 domai
      0.008   14.7   0.0      0.011   14.3   0.0    1.2  1  Cytochrom_D1  Cytochrome D1 heme domain
  ------ inclusion threshold ------
      0.069   12.4   0.0       0.13   11.5   0.0    1.4  1  Lactonase     Lactonase, 7-bladed beta-propeller


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0   0.00097       4.3      15      37 ..     108     130 ..      91     131 .. 0.88
   2 ?   -3.1   0.0         4   1.8e+04      12      20 ..     163     171 ..     155     176 .. 0.75
   3 ?   -0.6   0.0      0.67     3e+03      19      38 .]     222     245 ..     213     245 .. 0.70
   4 ?    4.0   0.0     0.023     1e+02       9      38 .]     278     309 ..     269     309 .. 0.78
   5 !   16.1   0.3   3.6e-06     0.016      11      38 .]     325     353 ..     313     353 .. 0.68
   6 ?   -0.9   0.0      0.83   3.7e+03      26      35 ..     388     397 ..     366     399 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00097
                 EEEEETTSSEEEEEETTSEEEEE CS
        WD40  15 slafspdgawlasGsdDgtvriW 37 
                 ++++spdg  l+s s D+ vr++
  EFC36628.1 108 GIKWSPDGLCLLSNSNDNIVRLF 130
                 799*********8899*****97 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 4
                 SEEEEEEET CS
        WD40  12 svtslafsp 20 
                 ++++++++p
  EFC36628.1 163 CINDFCWNP 171
                 489998876 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.67
                 ETTSSE.....EEEEETTSEEEEEE CS
        WD40  19 spdgaw.....lasGsdDgtvriWd 38 
                 s +g++     + +G  D+ + ++d
  EFC36628.1 222 SFNGKLsqgnkIYCGL-DQRICVFD 245
                 5555555555578776.99999987 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.023
                 SS.SSEEEEEEETTSSEE.EEEETTSEEEEEE CS
        WD40   9 GH.ssvtslafspdgawl.asGsdDgtvriWd 38 
                 G+ +++++++f+p    + ++G++++t+ ++d
  EFC36628.1 278 GQtGFISCFDFNPIEENIyVAGCYNNTIGVYD 309
                 66566****999999998448999*9998887 PP

  == domain 5  score: 16.1 bits;  conditional E-value: 3.6e-06
                 SSEEEEEEETTSSEEEEEE.TTSEEEEEE CS
        WD40  11 ssvtslafspdgawlasGs.dDgtvriWd 38 
                 ++v++++fs+dg++l+ +s +  ++  Wd
  EFC36628.1 325 TGVNCVKFSSDGNYLLVSSrKSDKIVCWD 353
                 36************976652566666665 PP

  == domain 6  score: -0.9 bits;  conditional E-value: 0.83
                 EEEETTSEEE CS
        WD40  26 asGsdDgtvr 35 
                 ++G+ Dg+++
  EFC36628.1 388 CAGTCDGKIK 397
                 3565699998 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.0    0.0001      0.45      42      89 ..     107     152 ..      95     154 .. 0.83
   2 ?    0.1   0.0      0.22     1e+03      56      79 ..     186     209 ..     156     225 .. 0.59
   3 !    9.3   0.0    0.0003       1.3      40      91 ..     282     334 ..     255     350 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0001
  ANAPC4_WD40  42 rsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                  ++++W+pdg  L    +d+ vrl++  ++ + +++s +++   + ++W
   EFC36628.1 107 KGIKWSPDGLCLLSNSNDNIVRLFELPQEILGRNFSENAN--FSHIEW 152
                  689*********************9988887777776666..777777 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.22
  ANAPC4_WD40  56 aysdgevrlldaesgkvvhslsvk 79 
                  + s+  v++ da +g++++s+ v 
   EFC36628.1 186 VSSKQPVHMWDAFNGNLLNSFMVR 209
                  234556777777777777776665 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.0003
  ANAPC4_WD40  40 evrsLaWkp.dgklLavaysdgevrlldaesgkvvhslsvksekavtclgWge 91 
                   ++++ ++p ++++ + ++ ++++ ++d +   v h ++++  + v+c+++++
   EFC36628.1 282 FISCFDFNPiEENIYVAGCYNNTIGVYDQNLDSVQHVIECEYGTGVNCVKFSS 334
                  56677777624556677899999999999999999999999999999999875 PP

>> Cytochrom_D1  Cytochrome D1 heme domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   2.5e-06     0.011     279     348 ..     292     357 ..     261     375 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.5e-06
                   -SEEEEE-TT-SSHT-EEEEETTBT-EEE-HHHHHT--EEEEEE-TTSSEEEEEEE--SSEEEEEETTTT CS
  Cytochrom_D1 279 skqlwvdaflnpdndsvaviDkktlekvltlaesaglkvvhvEfnkdGdevwlSvwdgkdalvvyDdktl 348
                   +++++v    +  n+ + v+D++   + + ++ + g  v  v f++dG+++++S + ++ ++v +D + l
    EFC36628.1 292 EENIYVA---GCYNNTIGVYDQNLDSVQHVIECEYGTGVNCVKFSSDGNYLLVSSRKSD-KIVCWDLRNL 357
                   5666666...455899*****99999999999999999********************9.9*****8766 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   2.8e-05      0.13     198     273 ..     288     354 ..     285     374 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.8e-05
                 E-TTSSEEEEEETTTTEEEEEEEE-TTTEEEEEEEEESS-TSS-S---EEEEEE-TTSSEEEEEETSSTEEEEEEE CS
   Lactonase 198 FhpdgkiaYvvnELsstvsvfsydeatgaleelqtvstlpegftgknsaaeIrlspdgkflyvSnRgadsiavfav 273
                 F+p ++ +Yv++  ++t+ v++ +     l  +q v   +      ++   ++ s+dg++l vS+R +d+i+++++
  EFC36628.1 288 FNPIEENIYVAGCYNNTIGVYDQN-----LDSVQHVIECE----YGTGVNCVKFSSDGNYLLVSSRKSDKIVCWDL 354
                 666677777777777777777777.....77777776663....2235567999*****************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1096  (0.06113); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2429.33
//
Query:       EFC36629.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.3e-45  155.3   0.1    2.7e-45  155.0   0.1    1.1  1  PP2C       Protein phosphatase 2C
  ------ inclusion threshold ------
       0.11   12.4   0.1       0.16   11.8   0.1    1.3  1  PPP1R35_C  Protein phosphatase 1 regulatory subunit 35 C-term


Domain annotation for each model (and alignments):
>> PP2C  Protein phosphatase 2C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  155.0   0.1     3e-49   2.7e-45      72     258 .]      53     224 ..      18     224 .. 0.88

  Alignments for each domain:
  == domain 1  score: 155.0 bits;  conditional E-value: 3e-49
                 HHHHHHHHHHHHHHHHHHHHHHHCHCCT-EEEEEEEEEETTE...EEEEEESS-EEEEEETTEEEEECS---STTSHHHHHHHHHTT--EEECCEEETT CS
        PP2C  72 leqalrksfladtdeelksskantepsksGstavvalirgtk...lyvAnvGDSravLcrkgnakkeltedHkpsdedEreRIeeaggsvsngegrvng 167
                     +r++fl+ + e++ +       ++ Gsta++++i   +    y++nvGDSr+vLcr+g+++ +lt+dH+ps+ dEr+R+++agg++    +rvn 
  EFC36629.1  53 IPLLIRETFLE-INENVCK-----GNDRDGSTASIIYIPYIDekiAYIGNVGDSRIVLCRSGEPI-RLTVDHRPSEIDERRRVKDAGGTIY--GNRVNA 142
                 45578999999.7777777.....34779*******986655559********************.*************************..****** PP

                 TBSBSB-EE-GGGTCCCCCCSTSB---EEEEEEE-TT.EEEEEEE-HHHHTTSHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHCCHHCHC CS
        PP2C 168 sLavsRalGDlelkpketeeqlvsaePdvtsvkltee.defliLacdGlwdvlsdqeavdlvrdelekkkspeevaeelvdeaiargsedni 258
                  La +Ra+GD+ l p      +++++  + + ++  + def+++acdGlwd++s++e+v  vr+e +    p +++  l++ a+++gs+dni
  EFC36629.1 143 CLAITRAIGDKSLHP------YIISDASTMVMDFMFDrDEFIVVACDGLWDYVSEEEVVTSVRYEND----PVQASITLRELAYDKGSTDNI 224
                 **************9......9************9999**************************999....9******************97 PP

>> PPP1R35_C  Protein phosphatase 1 regulatory subunit 35 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   1.8e-05      0.16      58     106 ..       3      49 ..       1      62 [. 0.86

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.8e-05
   PPP1R35_C  58 YkdLvsldvdeeelisqeaqqRlslapreakakpkkeklpePdlldFfd 106
                 Y++L++l +++++l+    + R++l+ +e+++k+ +e++ e++l  + +
  EFC36629.1   3 YSELIELAIEKSNLLL--CKLREHLKYKEREQKTTEESIDEICLHSLSK 49 
                 9*************66..78899999999999988899*****998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       500  (0.0278878); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 1549.40
//
Query:       EFC36630.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.51    9.0  13.2       0.59    8.8  13.2    1.1  1  Ndc1_Nup        Nucleoporin protein Ndc1-Nup
        2.5    7.0  12.4        3.1    6.7  12.4    1.2  1  Miga            Mitoguardin
        4.9    7.0  20.5        6.4    6.6  20.5    1.3  1  SPX             SPX domain
        7.1    3.6  15.8        8.5    3.3  15.8    1.0  1  GREB1           Gene regulated by oestrogen in breast cancer
          8    4.9  20.1         11    4.4  20.1    1.3  1  Macoilin        Macoilin family


Domain annotation for each model (and alignments):
>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8  13.2   0.00016      0.59     369     476 ..      83     197 ..      43     238 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00016
    Ndc1_Nup 369 kasapvkelprlsksplkkkddeifgn.sltaeaspkssssskegvekalsslakspgqs.....psptarlsprarkllekaksrllskeqkealses 461
                 ++ +p  ++p++s +++k+k ++i  + s+ a++s++ ssss+++ +++ s+++++++q+     ++ t  +s++  +   +a +r+ s+ +++++ + 
  EFC36630.1  83 DSDSPLIDSPTISDDSPKTKPKNINLSlSSVASSSSSTSSSSSSSSSSSSSPTTTTHSQTitvisSNNTTLQSSSPSSQTYEAIERMASQRNQRKADRR 181
                 345566777888888888875555333433333333334445555555555566666666666642222222222233333466677777777777777 PP

    Ndc1_Nup 462 tikkkvekelaq.llk 476
                 ++k+k ++++++ +++
  EFC36630.1 182 AQKNKGNQQRVEpIQS 197
                 7777766666664444 PP

>> Miga  Mitoguardin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7  12.4   0.00086       3.1      67     183 ..      73     190 ..      34     212 .. 0.63

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00086
        Miga  67 asekksrssssksndtlslasskassssaklsgslqslasvksvnsssssaaansaswdkeeeeelklenitvltpenlylmGmelleealrrweqaLt 165
                  s+++s+s ++++   + + +    s ++k+++   sl+sv+s +ss ss+ ++s+s +++ + +++ + itv++++n  l+      ++ +  e   +
  EFC36630.1  73 SSSSSSSSLMDSDSPLIDSPTISDDSPKTKPKNINLSLSSVASSSSSTSSSSSSSSSSSSSPTTTTHSQTITVISSNNTTLQSSSPSSQTYEAIERMAS 171
                 12222222222222223332333333345999**********9999999999988888888889999999***********988887777777777666 PP

        Miga 166 vrsrqaedea.scssvklg 183
                  r++++ d+  ++++ +++
  EFC36630.1 172 QRNQRKADRRaQKNKGNQQ 190
                 6666654433033333333 PP

>> SPX  SPX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6  20.5    0.0018       6.4      74     177 ..      70     184 ..       7     221 .. 0.53

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0018
         SPX  74 esgnsaadasssepkdeae..........................slprrsplsrssrssssygglvssppsansssssddssesnpadsssssssses 146
                 ++++s++ +s        +                          +l+++s  s+ss++sss ++++ss++s+ ++++s++    +     s+++  +s
  EFC36630.1  70 DTNSSSSSSS--------SlmdsdsplidsptisddspktkpkniNLSLSSVASSSSSTSSSSSSSSSSSSSPTTTTHSQTITVIS-----SNNTTLQS 155
                 1111111111........11111112234443555555544444444444444444444444444444444444444444444444.....66677777 PP

         SPX 147 esssssspsllrrlfsesesreeksersyet 177
                 +s+ss++ + ++r++s  +++++k+ r+ ++
  EFC36630.1 156 SSPSSQTYEAIERMAS--QRNQRKADRRAQK 184
                 7777778888888855..4444444433333 PP

>> GREB1  Gene regulated by oestrogen in breast cancer
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3  15.8    0.0024       8.5    1083    1230 ..      40     186 ..      29     217 .. 0.47

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.0024
       GREB1 1083 vreksvgsdllesdaeklsstdnedeelqedgerpksnssavqstsdsv..aadaaeessktspvkvekseskdavesglsskasakselseasaaa 1177
                  v++k+   +++++ +++   td   + +++d++++ s+ss++ ++++ +  +   +++s kt+p++++ s s+ a +s+++s++s++s++s++s+++
  EFC36630.1   40 VNNKNNNEEIFDQSPNNVIITDDSPSVTTIDTNSSSSSSSSLMDSDSPLidSPTISDDSPKTKPKNINLSLSSVASSSSSTSSSSSSSSSSSSSPTT 136 
                  6777788888888888888888888888888888777777776554433112233444555556666554433333333333333333222212222 PP

       GREB1 1178 asaseeakspkasvtseeeeseeskekekeslsketesqlsleaseqkealda 1230
                  +++s++ +  +  +++++ +s++  +++ e ++ +  sq ++++++++++ ++
  EFC36630.1  137 TTHSQTITVIS--SNNTTLQSSSPSSQTYEAIE-RMASQRNQRKADRRAQKNK 186 
                  22222211111..11111111111112211111.1222222222222222211 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4  20.1    0.0031        11     301     421 ..      60     189 ..       2     239 .. 0.39

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.0031
    Macoilin 301 sessgsesellveesvkskssssssssn.............knskkasagsagssnssskkhsessksvtsssssknskkqklpaGkssaalkdaaens 386
                 ++ s s +++ +++s++s+ss   s+ +             k++ k+ + s +s+ sss + s+ss+s +sssss     ++  +  + ++++ + + s
  EFC36630.1  60 TDDSPSVTTIDTNSSSSSSSSLMDSD-SplidsptisddspKTKPKNINLSLSSVASSSSSTSSSSSSSSSSSSSPTTTTHSQ-TITVISSNNTTLQSS 156
                 11111111111111111111111111.12334444432222222222222222222222222222222222222211111111.111222222233333 PP

    Macoilin 387 lpnnqlskkdalvrLeadikkLkaeLqasrqteqe 421
                  p++q  + +a++r+ ++ ++ ka+ +a++++ ++
  EFC36630.1 157 SPSSQ--TYEAIERMASQRNQRKADRRAQKNKGNQ 189
                 33332..3344555555554445444444333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2241  (0.124993); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                       108  (0.00602376); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.77u 0.36s 00:00:01.12 Elapsed: 00:00:00.54
# Mc/sec: 1326.96
//
Query:       EFC36631.1  [L=442]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-51  175.0  24.9    3.4e-51  174.1  24.9    1.4  1  GpcrRhopsn4      Rhodopsin-like GPCR transmembrane domain
  ------ inclusion threshold ------
       0.14   11.6   0.3       0.21   11.0   0.3    1.2  1  Glyco_hydro_101  Endo-alpha-N-acetylgalactosaminidase


Domain annotation for each model (and alignments):
>> GpcrRhopsn4  Rhodopsin-like GPCR transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  174.1  24.9   3.8e-55   3.4e-51       3     257 .]     157     410 ..     155     410 .. 0.98

  Alignments for each domain:
  == domain 1  score: 174.1 bits;  conditional E-value: 3.8e-55
  GpcrRhopsn4   3 kleyeltllNggdflkshfSadeqgilelflvlvllyivlliinivvikalkkreekhtvlkllsvslllelislllllihlivYaynGigiellqil 100
                   +e++++ +N+g+f++++fS d qgile+++++v +y+++++ +i+ i +l + + +h +++++  sl++ +++ ++ +ihl+vY  +G+gi++++ l
   EFC36631.1 157 YIELDFKWTNPGGFFTKQFSKDRQGILEVHIAFVPFYTIMVFAYIISIVQLIRHKSFHLIIRVFYSSLVVYWLGRVVEMIHLFVYGADGVGIPFFDDL 254
                  6899********************************************888899******************************************** PP

  GpcrRhopsn4 101 geildilsqilfllLLlllakGWtitraklsslstvillvlivlivvlqvilvil.eekfefdsaskihsyeslaGylllalrivlaiyFlyglrnti 197
                  +  l+ l ++l+l+LL lla GWtit + +   ++ +++++++++ v+++ l+ + +++ +f ++++ + y++++G++++++ri ++ +F++ l +t 
   EFC36631.1 255 AVGLKLLGDFLMLVLLYLLASGWTITTSYIR--YFKQTVGVWIFFGVFYIALYAWaQIELIFVVNTEDYIYDTIPGIIISVMRIPAMAFFIFVLFKTH 350
                  ******************************9..**********************5568899************************************ PP

  GpcrRhopsn4 198 kkekskkkkqFllkfgivgllwflsfPvlviiavfvdpyvrekvitigtilvqlvaiivl 257
                  ++e++k kk F++ +g++++lwf+s+P++v i+  +    r k i++++++++l++++v+
   EFC36631.1 351 QEETNKLKKVFYKVIGLLYSLWFISLPLIVSISFAIPVSHRAKWIEGLSLSIDLISYLVM 410
                  *********************************************************998 PP

>> Glyco_hydro_101  Endo-alpha-N-acetylgalactosaminidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.3   2.3e-05      0.21     130     194 ..      38     101 ..      22     117 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 2.3e-05
                      -TTEEESSSEEEEB-HHHHHHTT.HHHHHHHHHHHH-.T--EEEEEST.STTSHHHHHHHHHHHCT CS
  Glyco_hydro_101 130 ekkgWdWldqsyaidsreDlasgkllkRfkelreelgeeldfiYvDvy.resgwaskklskelnkq 194
                       +++W Wld s+  d++   + g ++ ++++++++ +++l+ +Yv  y  esg+    l++ +n++
       EFC36631.1  38 LNHQWIWLD-SFVFDNMGMKEPGYITWQLNNIKKQDPTALKNLYVSLYdDESGY-WPALQNYINSN 101
                      3569****9.789999999*****************************545553.45677777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (442 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       814  (0.0454013); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2825.16
//
Query:       EFC36632.1  [L=503]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.018   15.0   0.0      0.073   13.0   0.0    2.2  1  UBA       UBA/TS-N domain


Domain annotation for each model (and alignments):
>> UBA  UBA/TS-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0     4e-06     0.073       3      37 .]     464     498 ..     462     498 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 4e-06
                 HHHHHHHHHTTS-HHHHHHHHHHTTTSHHHHHHHH CS
         UBA   3 eeaiqrLveMGFdreevveALratgnNeErAveyL 37 
                 e+++  +v+ GF ++ ++ AL + +++  rA++yL
  EFC36632.1 464 EKSVGFMVDIGFQEDSARNALIQYNGDRTRAINYL 498
                 5666669***************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4584  (0.255675); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        98  (0.005466); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.29u 0.33s 00:00:01.62 Elapsed: 00:00:00.59
# Mc/sec: 2556.94
//
Query:       EFC36633.1  [L=1039]
Description: hypothetical protein NAEGRDRAFT_82154 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.5e-07   29.1   0.1    1.4e-06   28.0   0.1    1.5  1  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.1   7.8e-11   1.4e-06       1      63 [.     927     985 ..     927     990 .. 0.89

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 7.8e-11
                 EEEESE.TTTSSHHHHHHHHHTTSCEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEE CS
       RRM_1   1 lfVgnL.ppdvteeeLkelFskfGpiksiklvrdetgkskgfafVeFeskedAekAlealngkk 63 
                 l+Vg + +  ++ ++++  F+kfG+i s++l rd     +++afV+F+   dA +A+++l g+k
  EFC36633.1 927 LWVGRFhNMKMDYSTIYSDFEKFGQIDSLNLLRD-----QKCAFVNFALVKDAVRAKKELEGTK 985
                 567777677899999*******************.....***********************65 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1039 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1873  (0.104468); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.02u 0.31s 00:00:01.33 Elapsed: 00:00:00.52
# Mc/sec: 5984.47
//
Query:       EFC36634.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.6e-12   46.8   0.0      6e-05   22.8   0.1    2.8  2  His_Phos_1  Histidine phosphatase superfamily (branch 1)


Domain annotation for each model (and alignments):
>> His_Phos_1  Histidine phosphatase superfamily (branch 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.1   3.3e-09     6e-05       3      66 ..      46     124 ..      44     131 .. 0.76
   2 !   20.2   0.0   2.2e-08   0.00039      64     157 ..     143     238 ..     135     255 .. 0.89

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 3.3e-09
                 EEE---BTTB--....TT----B-HHHHHHHHHHHHHHTTS---EE................EE-SSHHHHHHHHHHHHC CS
  His_Phos_1   3 LvRHGetewnaegrlqgrtdvpLteeGreqAealaerlagepidai................ysSplkRarqTaeliaea 66 
                 L+RHG+  +n  g      d+ Lt++G+eq +++   + +++ +                  ++SplkR+++Ta  ++ a
  EFC36634.1  46 LLRHGQAYHNLLG-DANIRDPTLTPKGIEQSRQVNSLFVEVNDQLNthynnikelefrkyliIVSPLKRTIETAIYALSA 124
                 99*********97.45678999************9996553333333344445556667699************877665 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 2.2e-08
                 HHCTT--EEE-GGGS----GGGTT-B.HHHHHH..HSHHHHHHHHH-GGG-B..S-BHHHHHHHHHHHHHHHHHHTTTSEEEEEE-HHHHHHHHHH CS
  His_Phos_1  64 aealglpveldegLrEidfGdweglttaeiaeeypeeleawlrdpadvrppg..gEsledvaaRvaaaleelaarhegetvlvVsHggvirallar 157
                 +++ ++++ l++ ++E++ G++   t  e+++  +e++++ ++  ++  ++    E   ++++R++++   l + ++++++++++H g++  l++ 
  EFC36634.1 143 LQKYNIKLLLQPLIQEREAGKLPCDTGVELKQLDEEFYQHEFNILNTTFMESkwYEPKMEIRERMEKFKYWLDSLNDSNNIIIFTHHGFLMELTNG 238
                 5667899999*********************************99998888899***********************************9877765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1028  (0.0573373); expected 358.6 (0.02)
Passed bias filter:                      598  (0.0333538); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1573.85
//
Query:       EFC36635.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.6e-30  103.5  13.2    4.9e-19   67.9   7.0    2.5  2  PQ-loop          PQ loop repeat
  ------ inclusion threshold ------
      0.077   12.9   0.9       0.17   11.7   0.9    1.7  1  ODV-E18          Occlusion-derived virus envelope protein ODV
       0.31   11.3   9.2         12    6.1   6.8    2.7  2  EI24             Etoposide-induced protein 2.4 (EI24)
       0.78    8.8   5.6       0.86    8.6   0.7    2.0  2  vMSA             Major surface antigen from hepadnavirus


Domain annotation for each model (and alignments):
>> PQ-loop  PQ loop repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.9   7.0   1.1e-22   4.9e-19       2      58 ..      47     103 ..      46     106 .. 0.96
   2 !   39.2   0.4   9.7e-14   4.3e-10       2      35 ..     229     262 ..     228     263 .] 0.94

  Alignments for each domain:
  == domain 1  score: 67.9 bits;  conditional E-value: 1.1e-22
     PQ-loop   2 seilgyislvlwlvsyiPQiikNykrkSteGlSilflllwllGdilsllylilngfp 58 
                 s+++g++s++ +++s++PQiikN+  kS  GlSi+++++w++Gdi++l+++il++++
  EFC36635.1  47 SYVIGWLSILTSMISLFPQIIKNFTLKSSAGLSIYVFVIWMIGDITNLVGCILTNQL 103
                 89***************************************************9986 PP

  == domain 2  score: 39.2 bits;  conditional E-value: 9.7e-14
     PQ-loop   2 seilgyislvlwlvsyiPQiikNykrkSteGlSi 35 
                 + +++yis +++++++ PQ++kNykrk ++GlS+
  EFC36635.1 229 GIVCSYISCICYVAALAPQVYKNYKRKGVKGLSV 262
                 6699*****************************7 PP

>> ODV-E18  Occlusion-derived virus envelope protein ODV-E18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.9   3.9e-05      0.17       8      48 ..     163     203 ..     157     232 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.9e-05
     ODV-E18   8 ttstdagstrrlarlePsllltilvvlviiillvllvqsss 48 
                 + st +  t     + Ps +l  l  l+i+il++++ + + 
  EFC36635.1 163 SGSTSTEMTTTQKTILPSHYLPNLLTLIIVILMIVMAELTQ 203
                 3466666777778899****************999987665 PP

>> EI24  Etoposide-induced protein 2.4 (EI24)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   6.8    0.0028        12      39      78 ..      52     108 ..      28     140 .. 0.68
   2 ?    3.9   0.0     0.013        58      13      70 ..     175     241 ..     164     260 .. 0.60

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0028
                 -.................TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        EI24  39 w.................vllasllvllllllplwlfplvalllaapfygllaekve 78 
                 w                 + l+s ++l+++++++w++  +++l++++++++la ++ 
  EFC36635.1  52 WlsiltsmislfpqiiknFTLKSSAGLSIYVFVIWMIGDITNLVGCILTNQLATQIY 108
                 23333344455566678888999******************************9983 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.013
                 TTTHHHHHHHHHHHHHHHHHHHHHHH...-...TTHHHHHHHHHHHHHHHHHH..HHHHHHHHHH.H CS
        EI24  13 pkllallllplllnlllfllllvlll...w...vllasllvllllllplwlfp..lvalllaapf.y 70 
                 + +l    lp ll+l++++l++v++        +++ +   +++  +p +l+   +v+ +++++  +
  EFC36635.1 175 KTILPSHYLPNLLTLIIVILMIVMAEltqGeeeIMMMVQSCVSSTEQPQYLYIlgIVCSYISCICyV 241
                 5666777788888888888776666655414442233333444444444444444777777776633 PP

>> vMSA  Major surface antigen from hepadnavirus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.7   0.00019      0.86     329     394 ..      42     107 ..       7     114 .. 0.76
   2 ?    2.8   0.4     0.011        50     201     264 ..     136     199 ..     123     239 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00019
        vMSA 329 swalekllwesvsvrfsslsllvpfvqwfvgkslvvllsallliwytsssltnilstflt.llailf 394
                 +  ++ +   + s++ s++sl+    + f  ks + l   +++iw+ +  +tn++  +lt +la+  
  EFC36635.1  42 NSDVASYVIGWLSILTSMISLFPQIIKNFTLKSSAGLSIYVFVIWMIGD-ITNLVGCILTnQLATQI 107
                 4456778889**********99999999******9999999****9986.55666555542676654 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.011
        vMSA 201 eilrsldswwislsflkGkmtcagqdsqaqisnhsvtscpptcpGyrwty.lrrfiifllillla 264
                 ++l+++  w  s ++ k ++      +   +s   +t+     p +     l + i+ l+i++ a
  EFC36635.1 136 KLLERVRNWKKSNESSKHATSSLQTSTSGSTSTEMTTTQKTILPSHYLPNlLTLIIVILMIVM-A 199
                 567888899999999998877776777778888888888888887655550555555555544.3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1856  (0.103519); expected 358.6 (0.02)
Passed bias filter:                      818  (0.0456244); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 1536.77
//
Query:       EFC36636.1  [L=310]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-42  146.6   0.1    2.3e-42  145.7   0.1    1.5  1  PhyH            Phytanoyl-CoA dioxygenase (PhyH)
  ------ inclusion threshold ------
      0.013   15.1   0.2      0.013   15.1   0.2    1.6  2  PrkA            PrkA serine protein kinase C-terminal domain
      0.018   14.4   3.8       0.12   11.8   0.1    2.2  2  P35             Apoptosis preventing protein
      0.022   15.2   0.0      0.063   13.7   0.0    1.8  2  2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase


Domain annotation for each model (and alignments):
>> PhyH  Phytanoyl-CoA dioxygenase (PhyH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  145.7   0.1     5e-46   2.3e-42       1     211 []      12     279 ..      12     279 .. 0.82

  Alignments for each domain:
  == domain 1  score: 145.7 bits;  conditional E-value: 5e-46
                 HHHHSEEEETTSS-HHHHHHHHHHHHHH........................HHHCHTTCCSEEEEECEE..ESTTCCCEE....CCCHHCHHHHTTH. CS
        PhyH   1 feedGylviegflsaeevealraeieal........................ldralesgdkidfffeek..aaadedgll....eksinkvghflhp. 68 
                 f+e+G+lv e+f+++e++++lr+ei+ +                        ldr+++ + +++ ff ek  +++ ++g+l     + ink+gh+ h+ 
  EFC36636.1  12 FNEQGFLVFENFIAEEMIKTLRDEIKTIvekdfhpnqnhsifstykqdskrdLDRYFDQSIDNISFFLEKsaNIDPNTGELkqdkFTCINKIGHAIHDq 110
                 799*************************99999999999999999999999955555555555544444411334556666777777789999999996 PP

                 ......HHHHHHHHHHHTSCEEEE...........EEEEEEEEEEEE-TTTCB-EEEEE-SGGGST...EES...GCCEEEEEEESS-B-TTBT-EEEE CS
        PhyH  69 ......rkvadlvrailgqdvyva...........avlqsmyqdifkqpkiGgevqpwHqDstflp...tdp...eesvvgvwialedateenGclrfi 144
                       +           q+ +++             lqsm+  ifkqp iGgev   HqD+tfl+     +   e  v+g+w+aledat +nGcl ++
  EFC36636.1 111 nkvfreF---------SHQESLFEivktlsqferpLLLQSMV--IFKQPFIGGEV-IAHQDATFLYnelD-EnekEKPVIGCWFALEDATTKNGCLYVL 196
                 6555552.........4444444444445555567669****..***********.**********8851.3456999********************* PP

                 TTGGGS-CCGTCCHHCSGCCTTS.................CCCTTTGHGSCEEEE.BTTTEEEEEETTSEEEE-TB.SSSXEEE CS
        PhyH 145 PGSHkweegplrrrlpeddteae.................ddeakkedeeeavpvevkaGdavlfhgrllHgsgaNrsdksRra 211
                 PGSHkw+   +r++++  ++e++                   ++ ++d +++++ve k+G++++ hg+llH+s++N+s+ksR a
  EFC36636.1 197 PGSHKWGCV-KRWERTPIEKENGsveyemkmrvekpdllpYTTEMDYDHDKYISVEAKKGTLIILHGYLLHKSFENTSEKSREA 279
                 ******777.56666666666669***************99999**************************************75 PP

>> PrkA  PrkA serine protein kinase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.2   2.9e-06     0.013      89     173 ..      26     115 ..      11     130 .. 0.80
   2 ?   -2.6   0.1      0.74   3.3e+03     205     246 ..     223     263 ..     213     267 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.9e-06
        PrkA  89 leflevvreeydervkkev....qeAllyseeeqieelvenY....ldhveayikkekvkdpiTgeelepderflrsiEeqigiseeakkdFR 173
                 +e+++++r e++ +v+k+     ++++   +++  ++++++Y    +d+++++ +k+   dp+Tge ++ + + +++i + i  ++   k FR
  EFC36636.1  26 EEMIKTLRDEIKTIVEKDFhpnqNHSIFSTYKQDSKRDLDRYfdqsIDNISFFLEKSANIDPNTGELKQDKFTCINKIGHAIHDQN---KVFR 115
                 677888888888888888744334788888888888888888666689******************99888888888888887666...4555 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.74
        PrkA 205 ekklfedvkdllklisstktpdkeqqkkveevverLvekfgY 246
                 e k+  ++ dll+++++  ++d+++   ve+   +L+  +gY
  EFC36636.1 223 EMKMRVEKPDLLPYTTEM-DYDHDKYISVEAKKGTLIILHGY 263
                 556666666999998866.67777778888888888888888 PP

>> P35  Apoptosis preventing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.7    0.0082        37      77     126 ..      59     109 ..      26     134 .. 0.77
   2 ?   11.8   0.1   2.6e-05      0.12      92     138 ..     239     285 ..     225     294 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.0082
         P35  77 qlerdysdqmdglhdnikyfkdeyysvscqkgsvlkskfakilks.hdytd 126
                 + +rd    +d   dni +f ++  ++  + g + + kf+ i k  h   d
  EFC36636.1  59 DSKRDLDRYFDQSIDNISFFLEKSANIDPNTGELKQDKFTCINKIgHAIHD 109
                 35688888899999*************************999884255555 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 2.6e-05
         P35  92 nikyfkdeyysvscqkgsvlkskfakilkshdytdeksieayekycl 138
                 ++ y +d+y sv ++kg+++  +   + ks++ t eks eay  + l
  EFC36636.1 239 EMDYDHDKYISVEAKKGTLIILHGYLLHKSFENTSEKSREAYTLHIL 285
                 678999*************999999999**************87765 PP

>> 2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.4   6.1e+03      63      82 ..     181     200 ..     157     212 .. 0.72
   2 ?   13.7   0.0   1.4e-05     0.063      58      95 ..     240     277 ..     190     282 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.4
  2OG-FeII_Oxy_5  63 qslvdvkpkeGdlvlFPswl 82 
                      +l d + k+G l++ P ++
      EFC36636.1 181 FALEDATTKNGCLYVLPGSH 200
                     55556778888888888765 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1.4e-05
  2OG-FeII_Oxy_5  58 akeenqslvdvkpkeGdlvlFPswlrHevlpnegeeeR 95 
                      + ++ ++++v++k+G+l++   +l H+  +n++e++R
      EFC36636.1 240 MDYDHDKYISVEAKKGTLIILHGYLLHKSFENTSEKSR 277
                     3346689****************************999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       774  (0.0431703); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1992.06
//
Query:       EFC36637.1  [L=745]
Description: exocyst complex family protein, subunit Sec15 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.035   14.3   0.3      0.035   14.3   0.3    4.1  5  COG5      Golgi transport complex subunit 5
      0.074   13.1   3.4       0.67   10.0   0.1    3.4  2  SPOB_ab   Sporulation initiation phospho-transferase B, C-ter


Domain annotation for each model (and alignments):
>> COG5  Golgi transport complex subunit 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.3   3.9e-06     0.035      45     118 ..      94     167 ..      81     185 .. 0.90
   2 ?   -3.5   0.0       1.2   1.1e+04      54      82 ..     338     366 ..     331     369 .. 0.69
   3 ?   -2.0   0.5      0.43   3.9e+03      53      82 ..     378     407 ..     373     412 .. 0.73
   4 ?    0.7   0.0     0.061   5.5e+02      83     122 ..     532     571 ..     527     578 .. 0.73
   5 ?   -2.6   0.6      0.63   5.7e+03      63      95 ..     610     642 ..     593     655 .. 0.45

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3.9e-06
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-TTHHHHHHHHHHHHHHHHHHHHHHH CS
        COG5  45 ldkrlrqlitsnhleLlehlskskslssvlselksslesLsasyerlkskvlepyeeaeklqsalkrlhqtldL 118
                  +++++++++sn++e l+ +s+ ks +s  + lk++++ L + +++  ++ le  +++   ++ ++++h++l++
  EFC36637.1  94 QKTEIETICSSNYEEFLKSVSQLKSVRSDGKILKKKIIGLDEEVQKAGKEALECGKQLVLYRNIAENIHSALQV 167
                 5789****************************************************************998754 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.2
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        COG5  54 tsnhleLlehlskskslssvlselkssle 82 
                   nh +Lle+ ++ k +s +  ++++ le
  EFC36637.1 338 EINHAPLLEQKKSDKDTSIYPATVQEWLE 366
                 55889999998888877767666666555 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.43
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        COG5  53 itsnhleLlehlskskslssvlselkssle 82 
                 + +  ++Ll++++ ++  +++l+++ +s++
  EFC36637.1 378 TLRTTSSLLSNIELNSMWEQSLQKILTSID 407
                 566778889988888888887777777664 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.061
                 XXXXXXXXXX-TTHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        COG5  83 sLsasyerlkskvlepyeeaeklqsalkrlhqtldLlrra 122
                 s + s+++lks +++ +e+a k   +  +  + + ++r +
  EFC36637.1 532 SYTTSIKQLKSGIMKLFEHAVKCLDKELNSSTGTGIARYV 571
                 5678999999999999999998766666666666666655 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 0.63
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-TT CS
        COG5  63 hlskskslssvlselksslesLsasyerlkskv 95 
                 ++  s+s+ss+ +  k+   ++++s er ++ +
  EFC36637.1 610 NAAVSTSESSTITYFKQVSMQVQQSKERGENSI 642
                 444444444433333333333444433333333 PP

>> SPOB_ab  Sporulation initiation phospho-transferase B, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.4     0.028   2.5e+02      36      81 ..     169     216 ..     153     244 .. 0.74
   2 ?   10.0   0.1   7.5e-05      0.67       3      56 ..     505     556 ..     503     621 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.028
                 HHHHHHHHHHHHHHHHB-SSS-EEEEEEE--SSSSEEEE..EEEES-B CS
     SPOB_ab  36 kLvelvrklfslldeavsqssenhllitieldengvrlf..fDfqGvl 81 
                 +L++ v++l + ++++++++++  +l t+e+ e+ +r    f+f+  +
  EFC36637.1 169 DLCKHVSTLATKVHQQIQEEKYFSALKTLEHLEKSIRTVhkFNFARFI 216
                 79999*******************999**9999988764125555555 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 7.5e-05
                 HHHHHHHHTTSS-SSEEEEEEESS---GGGGHHHHHHHHHHHHHHHHHHB-SSS CS
     SPOB_ab   3 laellLTfnWeahkltLeyeVlgevkdlsaydekLvelvrklfslldeavsqss 56 
                 ++e +LT   e +++ L+yeV     ++ +y + + +l + +++l+++av+  +
  EFC36637.1 505 FSEIVLTLATEVESFILDYEV--YCDRIVSYTTSIKQLKSGIMKLFEHAVKCLD 556
                 89*******************..4445666666666666666666666655433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (745 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1584  (0.0883485); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.79u 0.32s 00:00:01.11 Elapsed: 00:00:00.50
# Mc/sec: 4445.27
//
Query:       EFC36638.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   14.6   0.0      0.032   13.8   0.0    1.3  1  ArsR      ArsR transcriptional regulator


Domain annotation for each model (and alignments):
>> ArsR  ArsR transcriptional regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.8e-06     0.032      71     146 ..     125     201 ..     116     212 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.8e-06
        ArsR  71 ekeYhtsYskvqanfq.csledlsdiievafmsdeeleelvekiekeveegntsisdlsrklglsplfiralakrse 146
                  k Y  s+ k q+++  ++l  + +   v+ ++++el++ +e+i +  ++++ts s+l  + + sp f  ++ kr e
  EFC36638.1 125 LKRYCKSFAKTQISLCpMPLPSIHQGFDVSSSHEDELQTNCESIVSSFRSNSTSSSSLLSSQQSSPNFSGSMLKRME 201
                 489999*******98648999***********************************************999999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1528.57
//
Query:       EFC36639.1  [L=568]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    6.5e-08   32.6  15.0    1.5e-07   31.4  15.0    1.6  1  Zn_clus    Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
      0.039   14.0   0.1        0.1   12.6   0.1    1.8  1  DNMT1-RFD  Cytosine specific DNA methyltransferase replicatio


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4  15.0   1.7e-11   1.5e-07       2      39 ..      42      78 ..      41      79 .. 0.93

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 1.7e-11
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                +C+ Crk + +Cd+k+P+Cs+C++++++C  y+e++kr
  EFC36639.1 42 SCICCRKAHKRCDRKFPSCSKCIQRGVDCF-YNEPKKR 78
                8*****************************.8888776 PP

>> DNMT1-RFD  Cytosine specific DNA methyltransferase replication foci domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   1.1e-05       0.1      27      84 ..      62     116 ..      51     158 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.1e-05
                 STTTTT--EEEEEEEEETT.----SSTT.SEEEEE....ES-ECEEEEEECSSSSBEE CS
   DNMT1-RFD  27 leieknadifisgvvkdidsedeekkkekgiedkglqiklgpIkeWtisgvdegekal 84 
                 + i++++d f ++ +k  +  +e   ++k i+++g   +l++I+++++s++++g +++
  EFC36639.1  62 KCIQRGVDCFYNEPKKRGK-ASETYRQKKRIKQDG--TELKQIVHYYYSYMAGGYPII 116
                 5578889999999998888.566777777888888..99***************8444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (568 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       940  (0.052429); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.28s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 3459.00
//
Query:       EFC36640.1  [L=381]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.2e-08   33.5   0.1    0.00031   20.6   0.0    3.1  2  LRR_6       Leucine Rich repeat
      0.003   17.4   0.2     0.0057   16.5   0.2    1.5  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.013   15.9   1.4      0.051   14.0   0.2    2.4  3  LRR_4       Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   5.2e-08   0.00031       4      24 .]     112     132 ..     111     132 .. 0.93
   2 !    9.5   0.0   0.00018       1.1       5      21 ..     139     155 ..     137     157 .. 0.94

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 5.2e-08
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+Ld+s+NdIg +G+e L+
  EFC36640.1 112 CLTALDVSDNDIGSAGIEQLS 132
                 7*****************996 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00018
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt+L +  N+Ig eGa+
  EFC36640.1 139 LTSLKIFNNNIGEEGAK 155
                 9**************97 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.2   9.6e-07    0.0057       2      38 ..      20      58 ..      19      67 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 9.6e-07
  F-box-like  2 srLPdEiLl.qIFsyLppsdLlr.lalVCrrWrrvaldt 38
                +++Pd++ + +IF +L+ +dL +  +lVC++W++ +l t
  EFC36640.1 20 NSIPDDVFShKIFPFLSGNDLFNnQRLVCSSWNNRVLAT 58
                68899976527************66********988777 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.019   1.1e+02      23      39 ..     111     123 ..     102     133 .. 0.64
   2 ?   14.0   0.2   8.5e-06     0.051       1      37 [.     111     150 ..     111     153 .. 0.85
   3 ?    8.6   0.6   0.00043       2.5       2      29 ..     138     169 ..     137     169 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.019
                 TT--EEE-.-S-----G CS
       LRR_4  23 pnLkeLdLsgNnlitdl 39 
                 p L+ Ld+s+N    d+
  EFC36640.1 111 PCLTALDVSDN----DI 123
                 66666666666....54 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 8.5e-06
                 SS--EEE--SS---E-S-..HH..H-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..klpnLkeLdLsgNnlit 37 
                 p L+ Ld s+N + + +   l+  +++ L++L + +Nn+i+
  EFC36640.1 111 PCLTALDVSDNDIGSAGIeqLSkgNIKGLTSLKI-FNNNIG 150
                 679************9996644866999******.888885 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00043
                 S--EEE--SS---E-S-...HH.H-TT--EEE CS
       LRR_4   2 nLevLdLsnNqltdipl...le.klpnLkeLd 29 
                  L++L ++nN++ + +    l+ +l  L++L+
  EFC36640.1 138 GLTSLKIFNNNIGEEGAkfvLSgNLSGLTTLN 169
                 79***********98889775545******97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       572  (0.0319036); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.43
# Mc/sec: 2687.33
//
Query:       EFC36641.1  [L=561]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.1e-08   32.9  14.2    1.1e-07   31.8  14.2    1.6  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
        1.7    9.0   8.1        3.8    7.9   2.4    2.6  2  Muted     Organelle biogenesis, Muted-like protein


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.8  14.2   1.2e-11   1.1e-07       2      39 ..      34      70 ..      33      71 .. 0.96

  Alignments for each domain:
  == domain 1  score: 31.8 bits;  conditional E-value: 1.2e-11
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                +C++Cr  + KCd++ P+C++C k++ eC  yse++kr
  EFC36641.1 34 SCESCRHSHKKCDRQLPSCTKCSKKGIECN-YSEPKKR 70
                8*****************************.9999997 PP

>> Muted  Organelle biogenesis, Muted-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.3    0.0099        89      65     139 ..      28     109 ..       3     112 .. 0.74
   2 ?    7.9   2.4   0.00042       3.8      58     133 ..     471     546 ..     443     552 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.0099
       Muted  65 enLseln........kkleaalekverllqkeleeekrkseqlqekeeerkaeweeflkelqekkeevDeefeekveelkekY 139
                 ++Ls+++        kk++  l ++++  +k  e ++++ ++  ++ +++k+++++  ++  ++++    ++e+ +++++e Y
  EFC36641.1  28 TSLSTIScescrhshKKCDRQLPSCTKCSKKGIECNYSEPKKRGKASDAYKKNKKQK-TDFPHQNQIAQSSHEDLIQQVSEFY 109
                 3444444444444449999999*********99999999999998887777766654.7778888888899999999999888 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00042
       Muted  58 kclesmkenLselnkkleaalekverllqkeleeekrkseqlqekeeerkaeweeflkelqekkeevDeefeekve 133
                 ++ +  + + ++ln +  +al   + + q++++++++++++  ++  e  ++w +++k l+  ke++ ++ +e+ e
  EFC36641.1 471 TLQNHYNMQVNTLNLATAQALRLPTIIAQQQQHQQHQQQHTSPQSSHEGDDKWMSLIKYLEAIKERIGNQPSEEPE 546
                 33444677788888888899999999****9999999999999999********************9998777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (561 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1342  (0.0748508); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 3658.23
//
Query:       EFC36642.1  [L=549]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-07   30.9  14.9    5.3e-07   29.7  14.9    1.7  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
     0.0065   17.0   0.0      0.039   14.5   0.0    2.2  2  FDC-SP    Follicular dendritic cell secreted peptide


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7  14.9   5.9e-11   5.3e-07       2      39 ..      43      79 ..      42      80 .. 0.93

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 5.9e-11
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                +C+ Crk + KCd++ P+Cs+C++++  C  y+e++kr
  EFC36642.1 43 SCICCRKAHKKCDRQLPTCSKCIQRGIACA-YNEPKKR 79
                8*****************************.8887776 PP

>> FDC-SP  Follicular dendritic cell secreted peptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   4.3e-06     0.039       7      53 ..      87     133 ..      83     140 .. 0.92
   2 ?   -1.5   0.0      0.43   3.8e+03      42      59 ..     450     467 ..     447     469 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 4.3e-06
      FDC-SP   7 qeRekRsisdsDeLaseflvfPygyPFrpyPpifyqryPWyrnnFli 53 
                 q+R kR   d DeLa +++ + y++  +++P i  +++ ++ n +l 
  EFC36642.1  87 QQRKKRKEQDLDELAANVIHYFYTFISGGHPVIRKPKFEYFVNHYLA 133
                 99*********************9999**************999875 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.43
      FDC-SP  42 qryPWyrnnFliPisesa 59 
                 +ryP  rn F   i+e++
  EFC36642.1 450 KRYPRVRNSFGSLINEIQ 467
                 79********98888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (549 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       915  (0.0510346); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.25s 00:00:00.74 Elapsed: 00:00:00.42
# Mc/sec: 3936.35
//
Query:       EFC36643.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.011   16.0   0.3        1.1    9.6   0.0    2.2  2  Orf78     Orf78 (ac78)


Domain annotation for each model (and alignments):
>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   6.1e-05       1.1      43     100 ..      23      82 ..       4      85 .. 0.69
   2 ?    4.5   0.1    0.0023        41      47      96 ..     187     237 ..     142     245 .. 0.52

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 6.1e-05
       Orf78  43 aaeknditekesnaaekaqalnillisllavvcvlvl..lyviyYfvilrerqkssvkep 100
                 +  +  i e++++++++ + ++i+l  + a++ +lv+  l + +Yf ++ + + s +++p
  EFC36643.1  23 SLGTAMIAEEQEESRKECKRKSIFLCIFTAFFLMLVIpqLSLFIYFYLTVDSDPSLANDP 82 
                 445556666666667777788888888999999999866667777777777777766666 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0023
       Orf78  47 nditekesn......aaekaqalnillisllavvcvlvll..yviyYfvilrerqkss 96 
                 +       +        ++  +  i +  l++ +c+ +++  +vi ++ + r+ +++ 
  EFC36643.1 187 V-------SvnsisrLYNSYYFAMIAMGILMSGFCLAIIIgwMVIPFINLKRDGPRRR 237
                 2.......12223211333333344444566779999998878888887878744443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1067  (0.0595125); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1549.52
//
Query:       EFC36644.1  [L=337]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.1e-25   89.3   0.0    7.6e-25   87.5   0.0    1.8  1  adh_short     short chain dehydrogenase
    7.7e-17   61.6   0.0      3e-16   59.7   0.0    1.7  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
     0.0019   18.1   0.1     0.0034   17.3   0.1    1.3  1  KR            KR domain


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.5   0.0   1.3e-28   7.6e-25       1     185 [.      44     254 ..      44     259 .. 0.86

  Alignments for each domain:
  == domain 1  score: 87.5 bits;  conditional E-value: 1.3e-28
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHH.HHHHHHSSESEEEE---S.......S- CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealve.kavkklgkldvLvnNAGi.......tg 89 
                 kv +vtGa sG+G++++  lak+G+++ ++ r+ee+ +e+++++ +e  +++++   vD+++ ++++++++ ++ + + kl++LvnNAG          
  EFC36644.1  44 KVCIVTGANSGLGYQTSIDLAKRGCTLHLLCRNEERGKEAVQNIIKEsnNEQVYLHIVDMSSVKSIKQFLDsQIGNTIPKLNILVNNAGAiveridpVT 142
                 789****************************************98887888899999************973677777************9*9996433 PP

                 -SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHH.....HCTTEEEEEEEE...........GGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGTE CS
   adh_short  90 sgpfselseeewervievNltgvflltravlpaml.....kqssGrIvnvsS...........vagkvpvagvaaYsAsKaavagltrslakelaptgi 172
                 ++++  l+e+ +e+ + vN  g++ ltr++++ m      ++ + r+++vsS           +  ++++ g +aY+  K     +t+++ak + ++ i
  EFC36644.1 143 KTAQVTLNENGYENNFLVNTIGPYYLTRELINFMEesakkDKDASRVIFVSSggmltsrldlnNLQNQGFTGASAYAHCKRQSCCITEEWAKLHDKSLI 241
                 33444455555***********************9999988999********3333333332224568999**************************** PP

                 EEEEEEESSBSSH CS
   adh_short 173 rvnavaPGlvdTd 185
                 + n+++PG vdT+
  EFC36644.1 242 TFNSCHPGWVDTP 254
                 ************7 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.7   0.0     5e-20     3e-16       1     179 [.      50     256 ..      50     276 .. 0.86

  Alignments for each domain:
  == domain 1  score: 59.7 bits;  conditional E-value: 5e-20
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE.E..EE--TTSHHHHHHHHH.HHHHHHSSEEEEEE-----EG.....CSS-G CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgae.v..lecDVtdeeqvealve.evvekfgklDilvnnagiapk.....lkgpf 87 
                   Ga sg+G+++   la++G+++ l  +nee+ k++v+++ +e ++e v    +D ++ ++++++ + ++ +++ kl+ilvnnag   +      k+  
    EFC36644.1  50 GANSGLGYQTSIDLAKRGCTLHLLCRNEERgKEAVQNIIKESNNEqVylHIVDMSSVKSIKQFLDsQIGNTIPKLNILVNNAGAIVEridpvTKTAQ 146
                   899**************************************99776667889**********9983577777***********98887888777778 PP

                   GGH-HHHHHHHHHHHTHHHHHHHHHHHHHCTSC.......CEEEEEEEGG...........GTSBSTTTTHHHHHHHHHHHHHHHHHHHHGGGTEEE CS
  adh_short_C2  88 letsreefdraldvnlyslfllakaalplmkeg.......gsivnlssvg...........aervvpnynaygaaKaalealtrylAvelgpkgiRv 166
                   ++++++++++ + vn+ + ++l++++++ m+e+       ++++ +ss g           +++++++ +ay+ +K     +t  +A+   +  i+ 
    EFC36644.1 147 VTLNENGYENNFLVNTIGPYYLTRELINFMEESakkdkdaSRVIFVSSGGmltsrldlnnlQNQGFTGASAYAHCKRQSCCITEEWAKLHDKSLITF 243
                   8889************************998877888998889999987622222222222356788888*************************** PP

                   EEEEE--BHCTGG CS
  adh_short_C2 167 NavspgpikTlaa 179
                   N+ +pg+++T+  
    EFC36644.1 244 NSCHPGWVDTPGL 256
                   **********964 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.1   5.6e-07    0.0034       4      92 ..      47     134 ..      45     147 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 5.6e-07
                 EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS...--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE----- CS
          KR   4 litGGlGgLGlelarwlaekgarhlvllsRsa.aadedskaliaelealgaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvl 92 
                 ++tG+  gLG +++  la++g  +l ll R++ + +e+ ++ i+  e+++ +v +  +D s+ +++++ l++   ++ p+++  ++ Ag++
  EFC36644.1  47 IVTGANSGLGYQTSIDLAKRGC-TLHLLCRNEeRGKEAVQNIIK--ESNNEQVYLHIVDMSSVKSIKQFLDSQIGNTiPKLNILVNNAGAI 134
                 8********************6.577777773144444444555..3446688888899*********99765555559999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (337 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1030  (0.0574488); expected 358.6 (0.02)
Passed bias filter:                      696  (0.0388198); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 1950.82
//
Query:       EFC36645.1  [L=285]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.3e-48  163.7  15.4    6.5e-48  163.4  15.4    1.1  1  MIP             Major intrinsic protein
  ------ inclusion threshold ------
      0.051   13.7   1.3        0.9    9.7   0.1    2.6  2  DUF872          Eukaryotic protein of unknown function (DUF87


Domain annotation for each model (and alignments):
>> MIP  Major intrinsic protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  163.4  15.4   7.3e-52   6.5e-48       7     227 .]      20     235 ..      12     235 .. 0.91

  Alignments for each domain:
  == domain 1  score: 163.4 bits;  conditional E-value: 7.3e-52
                 HHHHHHHHHHHHHHHHHHHHHHHHCCCSSCSSSSTTSSHHHHHHHHHHHHHHHHHHHHHHHCHT-S-SHHHHHHHHHTTSSSHHHHHHHHHHHHHHHHH CS
         MIP   7 flravlAEflatlllvfigvgsalnvkkkvsslaslvsvtleavalafglalavlvylaagiSGaHlNPavTlallvarkisllrailYivaQllGaiv 105
                  +ra+lAE l+t ++vf+g+ sa+ +++k +          ++val++ ++l v + +++ iSGaH+N avT+++l++r+i l+ +i+Y++aQ++G+iv
  EFC36645.1  20 YWRAILAELLGTAIFVFLGTSSAV-FANKNE---------PVTVALGHIFGLLVCIHIFGPISGAHFNCAVTFGALITRNIGLVSGIVYMIAQIVGSIV 108
                 49*******************999.555553.........467******************************************************** PP

                 HHHHHHHHCHHHHHHTTTTSSSSSTTSSHHHHHHHHHHHHHHHHHHHHHHCSTTSSSSTCH........GHHHHHHHHHHHHHHHHHHHHST-SSHHHH CS
         MIP 106 aaallklltkglesraglfanslkpglsagqalvvEiiltfvLvlvvfaltddkrkvslge........laplaigllvaliilvgipltGaamNpArs 196
                 +aal  l+ k +  + g f   +++   a++++++EiiltfvLvl +f+++ +++++++++        +a+  i +++ +  +++++ltGa+mNpAr+
  EFC36645.1 109 GAALTTLIGKTV--VPGIFK-PPEDIDDAWRGFALEIILTFVLVLAIFGAAVKPQHFKKSNglhsitglIAAFPIAFALGAD-AMAGALTGASMNPARA 203
                 ****99999985..666666.8999999***************************999999999988888999999999876.566789********** PP

                 HHHHHHHTHSTTT.THHHHHHHHHHHHHHHHH CS
         MIP 197 lgpavvlnkfedh.wvylvGPliGailgalvY 227
                 +gp+vv   +  h w+y+ +P+iGa+lga+vY
  EFC36645.1 204 FGPQVVGGVWYAHsWIYYTAPFIGAALGAIVY 235
                 ********976555*****************9 PP

>> DUF872  Eukaryotic protein of unknown function (DUF872)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1    0.0001       0.9      31      87 ..       9      64 ..       2      74 .. 0.78
   2 ?    2.1   0.1     0.023   2.1e+02      39      86 ..     131     176 ..     116     186 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0001
      DUF872 31 sywlkhPkvkknrkvvlaallLlllGlvLlllgvvilvepseGvssavflvlGlllf 87
                  +++hP ++  ++++la ll +++  v l ++ +++++++e v  a   + Gll+ 
  EFC36645.1  9 KIYWRHPDIHVYWRAILAELLGTAI-FVFLGTSSAVFANKNEPVTVALGHIFGLLVC 64
                3489*************99888877.5567788888888888877777777777654 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.023
      DUF872  39 vkknrkvvlaallLlllGlvLlllgvvilvep...seGvssavflvlGlll 86 
                 + + ++  ++ ++L+++ lvL + g++++ ++   s+G +     ++Gl++
  EFC36645.1 131 IDDAWRGFALEIILTFV-LVLAIFGAAVKPQHfkkSNGLH----SITGLIA 176
                 77889999999999887.6777778888777633333433....4445554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       769  (0.0428914); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1752.46
//
Query:       EFC36646.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.078   12.8   0.0       0.22   11.3   0.0    1.7  1  zf-CHC2   CHC2 zinc finger


Domain annotation for each model (and alignments):
>> zf-CHC2  CHC2 zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   1.2e-05      0.22       9      61 ..      32      89 ..      24     102 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.2e-05
     zf-CHC2  9 lkeridivdvveeyvkLkkkgkdyval.....CPFHeektpsftvspekqfyyCfgCg 61
                ++ r+di d+++eyv+L ++++   +        FH+ ++ps + + ++++   + C+
  EFC36646.1 32 IQLRLDIEDLLREYVALMQASAPIASTnstmeQFFHQSNSPSHHSNLSNDIDNVYYCK 89
                67799*************99875544311111569*******9987766554444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1320  (0.0736237); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 984.19
//
Query:       EFC36647.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.1e-17   62.7   0.0    1.4e-16   61.7   0.0    1.5  1  Trypsin_2      Trypsin-like peptidase domain
    3.7e-08   33.5   0.4    2.9e-07   30.5   0.4    2.2  1  Trypsin        Trypsin
    5.8e-05   22.4   0.0    9.8e-05   21.7   0.0    1.3  1  Peptidase_S32  Equine arteritis virus serine endopeptidase S3
    0.00087   18.9   0.4       0.21   11.1   0.0    2.2  2  DUF31          Putative peptidase (DUF31)
     0.0013   17.4   1.0      0.019   13.6   0.0    2.5  3  Peptidase_S46  Peptidase S46
     0.0017   18.2   0.2     0.0039   17.0   0.0    1.7  2  Peptidase_S7   Peptidase S7, Flavivirus NS3 serine protease
  ------ inclusion threshold ------
      0.012   15.5   1.7      0.023   14.6   0.6    1.9  2  Peptidase_C3   3C cysteine protease (picornain 3C)
       0.18   12.3   0.0       0.54   10.8   0.0    1.8  1  CBS            CBS domain


Domain annotation for each model (and alignments):
>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.7   0.0   6.3e-20   1.4e-16       1     150 []      90     288 ..      90     288 .. 0.62

  Alignments for each domain:
  == domain 1  score: 61.7 bits;  conditional E-value: 6.3e-20
   Trypsin_2   1 GsGflvgsdglilTnaHvvdsadgaav...........kaikkkveeagadgrevpakvvaadp.....................elDlAllkvssder 67 
                 G++f+v++ + ++T++H+++++++               +  +++++ + d+  +  kv  +d                      + D+A+l++ ++++
  EFC36647.1  90 GTAFFVSESL-LMTAQHCIKPSHTIDGvvyflkstyidLSCCSRDSQFEIDDSSLIKKVQIVDRsnfekdiqqlkmpgkdvpwktSNDFAFLEL-DQRN 186
                 89*******9.********77777777666666666662333333333333222222222222233444444444455555444377*******.7777 PP

   Trypsin_2  68 aglpplplgpsealkggepvyvvGyp...........lggeksg....svssGivsgvve............sesaasgegesflqtdaatspGsSGGp 139
                    p++p+ +  +l +g+++yv+Gyp                       + s+++ g v+              + +  +g+++ +++++t  G+SG+p
  EFC36647.1 187 LTTPFIPVET--TL-EGNQCYVIGYPgtisiekfkkdY-----CrdldDTKSNQLWGKVQremgyfeckiasQGTFQVKTGDYLYTHNCPTLCGTSGAP 277
                 7777777766..44.555********565555544431.....033333333333333336777888888844555555556666************** PP

   Trypsin_2 140 lfdsdGrvvGl 150
                 +++++G+++G+
  EFC36647.1 278 VVNENGKLIGI 288
                 **********8 PP

>> Trypsin  Trypsin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.5   0.4   1.3e-10   2.9e-07      24     201 ..      87     294 ..      60     308 .. 0.66

  Alignments for each domain:
  == domain 1  score: 30.5 bits;  conditional E-value: 1.3e-10
                 EEEEEEEEEETTEEEEEGGGTTT.......................GGGEEE....EESESBTTSCTTTEEEEEEEEEEEETTEBTTTTTTTEEEEEES CS
     Trypsin  24 khlCgGslisenwvlTAaHCvsn.......................asdvkv....vlgehnlkksegkeqklkvekvivhpnynpstldnDiallklk 95 
                 + + +++ +se+ ++TA+HC++                        +s++++     +++ +++ +++ e++++  k ++ +++  +t +nD+a l+l+
  EFC36647.1  87 RSFGTAFFVSESLLMTAQHCIKPshtidgvvyflkstyidlsccsrDSQFEIddssLIKKVQIVDRSNFEKDIQQLK-MPGKDVPWKT-SNDFAFLELD 183
                 56889*****************9888888888887666666666553333334443333333333333333333333.4444444444.9********* PP

                 SSSTSBSSBHCCBBCSTTHTTSTTTEEEEEESSBSSTSSBSSBEEEEEEEEEEHHHHHHHTTTT...........STTTEEEEESTTSS.SBCTT...T CS
     Trypsin  96 epvklgdtvrpiclpaassslpvgttclvsGwgrtkekgksdtlqevevpvvsretcksaykgk...........vtenmlcagakegg.kdacq...G 179
                 ++ +l+    p+++        +g +c+v+G++ t + +   + ++++ + +++ + ++ +++             ++ ++++++ ++     c+   G
  EFC36647.1 184 QR-NLTTPFIPVETTL------EGNQCYVIGYPGTISIE---KFKKDYCRDLDDTKSNQLWGKVqremgyfeckiASQGTFQVKTGDYLyTHNCPtlcG 272
                 **.7777777777776......799*******9965555...55555555555544444333334445555666656666666666555555554444* PP

                 TTTSEEEETTTEEEEEEEEESS CS
     Trypsin 180 DSGGPlvcsdgelvGivswgkg 201
                  SG P+v+++g+l+Gi+ +g+ 
  EFC36647.1 273 TSGAPVVNENGKLIGIHVGGDY 294
                 *****************99954 PP

>> Peptidase_S32  Equine arteritis virus serine endopeptidase S32
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.0   4.4e-08   9.8e-05     203     229 ..     267     293 ..     254     318 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 4.4e-08
                    ----GGGTT-EEEETTE.EEEEEEEEE CS
  Peptidase_S32 203 cftkcGDsGspvvdedgelvGvhtGsn 229
                    c t cG sG+pvv+e+g+l+G+h G +
     EFC36647.1 267 CPTLCGTSGAPVVNENGKLIGIHVGGD 293
                    6799********************987 PP

>> DUF31  Putative peptidase (DUF31)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.1    0.0028       6.3     187     280 ..     157     239 ..     133     261 .. 0.63
   2 !   11.1   0.0   9.3e-05      0.21     352     372 ..     270     290 ..     249     291 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0028
       DUF31 187 ddeelaknitndayaaldnklkqikfislksllkeakykkldekldtdkqkttleeakklyilGYPtseed.tylddeed.tkeedsqslwinkes 280
                 +d +++k   +d     +++++ + f++l++    ++   ++++l          e ++ y++GYP + +  ++ +d+ +     +s++lw + ++
  EFC36647.1 157 KDIQQLKMPGKD---VPWKTSNDFAFLELDQRNLTTPFIPVETTL----------EGNQCYVIGYPGTISIeKFKKDYCRdLDDTKSNQLWGKVQR 239
                 333333333333...357777777777755544444555555543..........44449******877764555555557555666899987665 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 9.3e-05
       DUF31 352 agGaSGSlvrnkdnklvGIyf 372
                   G SG++v+n+++kl+GI+ 
  EFC36647.1 270 LCGTSGAPVVNENGKLIGIHV 290
                 569****************96 PP

>> Peptidase_S46  Peptidase S46
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1     0.038        85      46      67 ..      87     107 ..      70     112 .. 0.85
   2 ?   -2.3   0.0      0.54   1.2e+03     240     252 ..     199     211 ..     194     217 .. 0.87
   3 !   13.6   0.0   8.5e-06     0.019     630     656 ..     268     294 ..     244     302 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.038
                    TTTEE-EE-STT-EEEE-HHHH CS
  Peptidase_S46  46 lggCtasfVSpeGLvlTNHHCa 67 
                     ++ ta fVS++ L++T  HC+
     EFC36647.1  87 RSFGTAFFVSES-LLMTAQHCI 107
                    4789******86.9*******7 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.54
                    TT-EEEEEE---- CS
  Peptidase_S46 240 egdlvfvlGyPGs 252
                    eg+ + v+GyPG+
     EFC36647.1 199 EGNQCYVIGYPGT 211
                    8999********7 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 8.5e-06
                    ---TT-TT-EEE-TTS-EEEEEEEE-G CS
  Peptidase_S46 630 DitGGNSGSPvlngkgelvGlaFDgni 656
                     +  G SG+Pv+n++g+l+G+   g +
     EFC36647.1 268 PTLCGTSGAPVVNENGKLIGIHVGGDY 294
                    56789****************988876 PP

>> Peptidase_S7  Peptidase S7, Flavivirus NS3 serine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       3.4   7.6e+03      46      63 ..      49      66 ..      40      76 .. 0.51
   2 !   17.0   0.0   1.7e-06    0.0039      94     120 ..     270     296 ..     230     306 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.4
                  TTEEEXEEEEETTTTEEE CS
  Peptidase_S7 46 qkkktkpswaSvkedlvk 63
                  +   +k+ ++Svk+ +  
    EFC36647.1 49 ESHTSKTLSGSVKKAIQT 66
                  333334444444444433 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 1.7e-06
                   XTT-TTSEEE-TTSXEEEECEEEEEXT CS
  Peptidase_S7  94 ssGsSGSlvlnqnkqivgiYfatvevd 120
                     G+SG +v+n+n++ +gi  +++   
    EFC36647.1 270 LCGTSGAPVVNENGKLIGIHVGGDYAL 296
                   56******************9998765 PP

>> Peptidase_C3  3C cysteine protease (picornain 3C)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.4   3.1e+03      94     134 ..      20      59 ..      13      65 .. 0.71
   2 ?   14.6   0.6     1e-05     0.023     139     173 ..     262     293 ..     236     293 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.4
                   -SS---EEEEEEEE-SSSSTTEEEEEEEEEEEEEE.EETTE CS
  Peptidase_C3  94 aarikkgkpvvllinnneagrlivsveavtakgkiktldgt 134
                      + ++ +   +i++++ g+l  s++ +t++ + ktl+g 
    EFC36647.1  20 DIAM-DYADSGECIFSDNEGNLQGSIHLITESHTSKTLSGS 59 
                   4445.566666788888888888888888888888888875 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1e-05
                   EEEESS---TT-TT-EEEE....TTEEEEEEEEE- CS
  Peptidase_C3 139 tlsYkaktkaGmCGgvviakeegngkilGiHvaGn 173
                   +   + +t  G  G++v+     ngk++GiHv+G+
    EFC36647.1 262 LYTHNCPTLCGTSGAPVVN---ENGKLIGIHVGGD 293
                   456688999********99...89**********6 PP

>> CBS  CBS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00024      0.54      30      45 ..     273     288 ..     263     288 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00024
                 SSEEEEEETTTBEEEE CS
         CBS  30 vsrlPVVdedgklvGi 45 
                  s+ PVV+e+gkl+Gi
  EFC36647.1 273 TSGAPVVNENGKLIGI 288
                 5799***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 1998.61
//
Query:       EFC36648.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       726  (0.0404931); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.50
# Mc/sec: 3006.61
//
Query:       EFC36649.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      2e-40  138.7   0.0    2.7e-40  138.3   0.0    1.1  1  ThiF           ThiF family
  ------ inclusion threshold ------
       0.14   12.7   0.0        0.3   11.7   0.0    1.5  1  F420_oxidored  NADP oxidoreductase coenzyme F420-dependent


Domain annotation for each model (and alignments):
>> ThiF  ThiF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  138.3   0.0     3e-44   2.7e-40       3     231 ..      42     290 ..      40     302 .. 0.83

  Alignments for each domain:
  == domain 1  score: 138.3 bits;  conditional E-value: 3e-44
                 HHHHHHHHHHHHHHHTSEEEEE--SHHHHHHHHHHHHHTTTEEEEEESSB--GGGGGTBTTS-GGGTTSBHHHHHHHHHHHT-TTSEEEEEES-CCGCC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF   3 rqlallgedgqekLrdskvllvGaGglGsellknLalsGvgkltlvDnDkielsNlnRqflfreediGkpKaevaaealqeinpdveveavteritdet 101
                 r++ l++++ q+k++++ v++ G+Gg G   + +La++Gv++++++D+D+ el N nRq+ ++ ++iG++Ka v  e + +inp ++ +a+t+ i++++
  EFC36649.1  42 RNIGLVSKEEQAKIERTCVAIAGCGGAGGGYASALARTGVSNFKFADFDHYELVNFNRQYGATVNSIGRNKAIVTSEIVLAINPLAKTKAFTNGIDESN 140
                 78888999****************************************************************************************988 PP

                 S-HHHHTT-SEEEEESSS..HHHHHHHHHHHHHHT-EEEEEEEETTEEEEEEEEE..CCS-ECTSS-.............TGGS.EECCCCEEHHH... CS
                 xxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxx.............xxxxxxxxxxxxxxxx... RF
        ThiF 102 vleellesvDlVvdalDn..iearrlvnracvkkgiplieagtlgfegqvvviip..gktgcyeCld.............psstedptekkvplct... 180
                   +++l +v++V+dalD     +rrl+ + ++kkgi + +ag+ g+++++++++p   + + ++C++                            t   
  EFC36649.1 141 -IDDFLDGVNVVMDALDLfaPRTRRLLYKHAHKKGIAVFTAGPIGYSCAWQIYLPtgPTFDDFCCMNdsmsdedlivrhlI--------------Taap 224
                 .69**************955679******************************9988777888888744444444433330..............3444 PP

                 .............HHHCT.E-B-HHHHHHHHHHHHHHHHHHH..TTBCGGGCCEEEECCTTTTEEEE CS
                 .............xxxxx.xxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF 181 .............siagn.ipaiatttavvaglaalellkll..sgkeklenslltqvdllesrfen 231
                              +  g   p+++++++++ g+++ e++ ++  +++ k  + ++ q+d+ +++f++
  EFC36649.1 225 agthlkymkaknvDLSGHaAPSLGPVCTMLHGILVIEVINFVtgKKPIKGVPHYF-QFDMMTNQFKT 290
                 44444443333333345588**********************5544555555666.67777777765 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   3.4e-05       0.3       2      81 ..      60     136 ..      59     145 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.4e-05
                    EEEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHHHHHC-EEECECHHHHHHH-SEEEE-S-HHHHHHHHHHC CS
  F420_oxidored   2 igiiGaGnmgealasgllaagaqpheivvansrnpekaeelaeelgvkvtavdneeaaeeadvvvlavkpedveevlsel 81 
                    ++i G+G  g + as l+++g   +++ +a + +  ++  + +++g++v +   ++a+  +++v+   + ++++++ + +
     EFC36649.1  60 VAIAGCGGAGGGYASALARTG--VSNFKFA-DFDHYELVNFNRQYGATVNSIGRNKAIVTSEIVLAINPLAKTKAFTNGI 136
                    6889*****************..999**99.999999*********9999988999999999998888888888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       560  (0.0312343); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1970.71
//
Query:       EFC36650.1  [L=136]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.6e-19   69.2   0.3    2.9e-19   69.0   0.3    1.0  1  DUF2368        Uncharacterised conserved protein (DUF2368)
  ------ inclusion threshold ------
      0.042   14.3   0.7       0.07   13.5   0.7    1.3  1  DUF4199        Protein of unknown function (DUF4199)
        2.9    8.1   7.9        4.5    7.5   7.9    1.2  1  YjfB_motility  Putative motility protein


Domain annotation for each model (and alignments):
>> DUF2368  Uncharacterised conserved protein (DUF2368)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.0   0.3   4.8e-23   2.9e-19       1     117 [.       1     119 [.       1     133 [. 0.85

  Alignments for each domain:
  == domain 1  score: 69.0 bits;  conditional E-value: 4.8e-23
     DUF2368   1 mgqllsksmeenlkknqefleemqklqlerqlamqnlmrerqmAlqiakarellkwlasfyalavvllaagaikrk..npllliPlvPLtfvlaYqydl 97 
                 mg++ s+  ++ + k++++  emq+ ++++q +  ++m++ q+A q+a are + w+a f + + ++l+ag ik+k  +p +++P    ++v+ Y +d+
  EFC36650.1   1 MGNIGSSIANSMAEKQKAVQVEMQEKMVQNQKKQGERMKRMQIATQVAIARERFWWMAGFHGFISTGLLAGLIKKKpiHPGVILPYTAYSLVVLYNWDF 99 
                 566444444444556669999*******************************************************777888888888999******** PP

     DUF2368  98 aYGdklerireeAerileee 117
                 aYGdkleri +   +i +e+
  EFC36650.1 100 AYGDKLERIDKIYSQIQKED 119
                 *********98777775554 PP

>> DUF4199  Protein of unknown function (DUF4199)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.7   1.2e-05      0.07      95     161 ..       8      73 ..       6      75 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.2e-05
     DUF4199  95 idpdfienyiaeilekleeakeesaeeenaemseeeikealeslspiivalqsflgnliiGlilsli 161
                 i ++++e+++a + e+ e++ ++++ ++++ m++ +i+ +++  ++ ++ +++f g +  Gl+ +li
  EFC36650.1   8 IANSMAEKQKAVQVEMQEKMVQNQK-KQGERMKRMQIATQVAIARERFWWMAGFHGFISTGLLAGLI 73 
                 5677899999999999888877777.678889*****999998888776666666666666665555 PP

>> YjfB_motility  Putative motility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   7.9   0.00075       4.5       5      41 ..       7      42 ..       5      51 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00075
  YjfB_motility  5 smamsqaklqqqvgisVlKkalDtqeeqadqLlkmme 41
                   s+a+s+a  q +v++ ++ k   +q+ q++ +  m +
     EFC36650.1  7 SIANSMAEKQKAVQVEMQEKMVQNQKKQGERMKRM-Q 42
                   8999****************************999.5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1596  (0.0890178); expected 358.6 (0.02)
Passed bias filter:                      693  (0.0386525); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.33s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 785.42
//
Query:       EFC36651.1  [L=439]
Description: hypothetical protein NAEGRDRAFT_59950 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      9e-12   44.8   0.0    9.8e-11   41.4   0.0    2.0  2  Hydrolase_4    Serine aminopeptidase, S33
    1.3e-09   38.0   0.0    1.7e-06   27.9   0.0    2.3  2  Abhydrolase_1  alpha/beta hydrolase fold
      5e-07   29.7   0.0    7.4e-05   22.7   0.0    3.1  3  Abhydrolase_2  Phospholipase/Carboxylesterase
    1.6e-05   24.0   0.3      3e-05   23.1   0.1    1.5  2  DUF818         Chlamydia CHLPS protein (DUF818)
    7.4e-05   22.8   0.0    0.00028   20.9   0.0    2.0  1  BAAT_C         BAAT / Acyl-CoA thioester hydrolase C terminal
    0.00013   21.9   0.0    0.00022   21.1   0.0    1.4  1  Abhydrolase_3  alpha/beta hydrolase fold
    0.00032   20.3   0.0     0.0024   17.4   0.0    2.1  2  Peptidase_S9   Prolyl oligopeptidase family
    0.00035   21.3   0.0    0.00046   20.9   0.0    1.2  1  Abhydrolase_6  Alpha/beta hydrolase family
     0.0076   15.8   0.0        1.5    8.3   0.0    2.5  3  DLH            Dienelactone hydrolase family
  ------ inclusion threshold ------
      0.011   15.4   0.0      0.029   14.0   0.0    1.8  1  FSH1           Serine hydrolase (FSH1)
      0.013   15.5   0.0      0.037   14.0   0.0    1.8  1  UPF0227        Uncharacterised protein family (UPF0227)
      0.029   14.2   0.0      0.079   12.8   0.0    1.7  1  Lipase_3       Lipase (class 3)
      0.037   13.7   0.0      0.077   12.6   0.0    1.5  1  Esterase       Putative esterase
      0.075   13.1   0.0       0.14   12.3   0.0    1.4  1  Thioesterase   Thioesterase domain


Domain annotation for each model (and alignments):
>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.4   0.0   7.7e-14   9.8e-11       6     159 ..     141     294 ..     137     297 .. 0.76
   2 ?    2.0   0.0     0.079     1e+02     191     213 ..     296     318 ..     289     340 .. 0.75

  Alignments for each domain:
  == domain 1  score: 41.4 bits;  conditional E-value: 7.7e-14
  Hydrolase_4   6 vvvlvHGlaehsgryaelaeaL.aaqGfavyalDhrGhGrsegkrghvpsfddyvdDlaafvekvkeehpel...plfllGhSmGGliallyllrypd 99 
                  +++++HG a  ++     a+++      +++++ +rG+G+s g+     s + + +D++++++ + e+ ++    ++f++G S+GG++++ ++ +y++
   EFC36651.1 141 TIIMFHGNAGNISHRLTNARDMyHTLKCNILMVEYRGYGKSTGEP----SEEGLKNDAETAIRYLLEKRSDInpnNIFIFGRSLGGAVSIYLASKYAN 234
                  788889876655555555555515568999***********7665....578888888888888886666555778********************** PP

  Hydrolase_4 100 kvaglilsaPalkikaklkappllklllkllgkllpklqvsnnlkadslsrdpevvaaye 159
                   ++g+i+ +++++i++ ++a   +++++ +l+ +  +   ++ ++ +   r+  ++++++
   EFC36651.1 235 AIRGVIVENTFMSIPKLIPAIFPYRFISPILQFFSVNKWDNEATLRNAQFRNDYHRKRLN 294
                  ***************887666777777777777766666666666666666666666554 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.079
  Hydrolase_4 191 tlPllllhGeaDkvvdpeasrel 213
                  +lP+l+++G +D++++      l
   EFC36651.1 296 DLPFLFISGRKDELIPATHMDTL 318
                  49************997766444 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   0.0   1.3e-09   1.7e-06       1     107 [.     140     248 ..     140     268 .. 0.81
   2 !    8.0   0.0    0.0015       1.9     183     239 ..     267     325 ..     262     345 .. 0.73

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 1.3e-09
                    SEEEEE-STTTCGGGGTTGHHHHHHHHT.TSEEEEEEETTSTTSSSTTTGB.CHHSHHHHHHHHHHH...HHHCTTSSEEEEEETHHHHHHHHHHH CS
  Abhydrolase_1   1 pvlvilhGlpgssdvwaerglapaLakd.gfdvillDlrGvgySspapacinddygtasvaddldri...ldalgddkltlvGhSmGGmialayaa 92 
                    p+++++hG +g+    +++  a++  ++ ++ ++++  rG+g+S+  p++  +   + + +  ++++   +   +  ++ + G S+GG+++ ++a+
     EFC36651.1 140 PTIIMFHGNAGNIS--HRLTNARDMYHTlKCNILMVEYRGYGKSTGEPSE--EGLKN-DAETAIRYLlekRSDINPNNIFIFGRSLGGAVSIYLAS 230
                    789********664..5555777777778*******************96..44444.4777777776668888999999**************** PP

                    HHGGGEEEEEEESE...C CS
  Abhydrolase_1  93 eyperVkalvllga...i 107
                    +y + +++++  ++   i
     EFC36651.1 231 KYANAIRGVIVENTfmsI 248
                    **********99994433 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0015
                    HHHHHHHHHHHHCCHHHHHHHHHCTHHHHS..EEEEEEETTCSSSCHHHHHHHHHC.HTS CS
  Abhydrolase_1 183 tgalksieqwpttdsaklllrlrelknvla..ptlvisgtsDplvppkaledlaql.lpk 239
                    +++++ ++  +t+ +a++ +++ + k  +   p l+isg++D l+p  +++ l +  + +
     EFC36651.1 267 FFSVNKWDNEATLRNAQFRNDYHR-KRLNGdlPFLFISGRKDELIPATHMDTLIEIyCER 325
                    678889999999999999999999.3332255***************8888777666444 PP

>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.74   9.4e+02       9      23 ..     134     148 ..     127     172 .. 0.73
   2 !   22.7   0.0   5.7e-08   7.4e-05      91     145 ..     195     251 ..     180     268 .. 0.85
   3 ?    2.8   0.0     0.068        88     150     199 ..     290     340 ..     278     346 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.74
                    -SS---EEEEEE--T CS
  Abhydrolase_2   9 pkdkaqavviflHGl 23 
                    ++ + ++++i++HG 
     EFC36651.1 134 KQLQYTPTIIMFHGN 148
                    5567789******94 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 5.7e-08
                    HHHHHHHHHTT..--GGGEEEEEETHHHHHHHHHHHT-SS--SEEEEES---TTGGG CS
  Abhydrolase_2  91 eelidaelkkg..ipssriiigGFSqGaalalylaltlpkklggivafsgalplsqk 145
                    e  i++ l+k   i+ ++i+i+G S G+a+++yla ++ + ++g++  + ++++++ 
     EFC36651.1 195 ETAIRYLLEKRsdINPNNIFIFGRSLGGAVSIYLASKYANAIRGVIVENTFMSIPKL 251
                    4567777777778*********************************99999988765 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.068
                    S-GGGGG-EEEEEEETT-SSS-HHHHHHHHHHHHTTS-.GEEEEEETT--S CS
  Abhydrolase_2 150 atavtkklpilqiHgeeDpvvplalgkaakevlkkllk.kvelksyeglaH 199
                      +++ +lp l i g +D+++p  ++ ++ e++ +     +  k + ++ H
     EFC36651.1 290 RKRLNGDLPFLFISGRKDELIPATHMDTLIEIYCERFGeYCYVKRFDEGTH 340
                    5667779*******************9998877655443666666666665 PP

>> DUF818  Chlamydia CHLPS protein (DUF818)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.1   2.4e-08     3e-05     166     229 ..     162     225 ..     144     238 .. 0.91
   2 ?   -3.9   0.0         4   5.2e+03     332     356 ..     371     397 ..     358     403 .. 0.48

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 2.4e-08
      DUF818 166 lakllganilvfnYPGvmsskGeitrenlakayqaCvrYLrDkeqGPkakeiiayGYsLGtlvq 229
                 + ++l+ nil+  Y G  +s+Ge + e l +  +  +rYL +k +  + ++i  +G sLG+ v 
  EFC36651.1 162 MYHTLKCNILMVEYRGYGKSTGEPSEEGLKNDAETAIRYLLEKRSDINPNNIFIFGRSLGGAVS 225
                 5567899******************************************************985 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 4
      DUF818 332 gkkipieevlllhkdpl..dekvikkl 356
                  +k+ ++++++l + +l  +++vi+++
  EFC36651.1 371 TRKHSVAKTHSLPQTELqmSDDVIDNI 397
                 455555555444433321134444443 PP

>> BAAT_C  BAAT / Acyl-CoA thioester hydrolase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.0   2.2e-07   0.00028       7     136 ..     195     317 ..     194     380 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 2.2e-07
                 HHHHHHHH.CSTTB--SSEEEEEETHHHHHHHHHHHHSS.SEEEEEEES--SB--S.SEEEETTE..EE----B-GGG-EE-TTS-EE-TT-B--TTTG CS
      BAAT_C   7 eeainyll.rhpkvkkdkigllGiSkGgelalllasflk.kisavvlingsavvve.gklvykdeskvlpelklsmeklkvnknglldivdvlallkek 102
                 e ai+yll +++ ++ ++i + G+S Gg + ++las++  +i+ v++ n    + +  ++++ +  + + ++   ++  k+ ++  l+ ++ +++ + k
  EFC36651.1 195 ETAIRYLLeKRSDINPNNIFIFGRSLGGAVSIYLASKYAnAIRGVIVENTFMSIPKlIPAIFPY--RFISPILQFFSVNKWDNEATLRNAQFRNDYHRK 291
                 7899997626789*************************98999999999877666413333333..588887666666666666666555555555544 PP

                 GGCCCB--GGG--SEEEEEEETT-SSS-HHHHHH CS
      BAAT_C 103 laekalipvekakgpillvvgedDknwpSkesae 136
                   +         + p+l+++g +D+++p+ ++  
  EFC36651.1 292 RLN--------GDLPFLFISGRKDELIPATHMDT 317
                 333........47899999999999999987754 PP

>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   1.7e-07   0.00022       4      95 ..     145     235 ..     142     286 .. 0.78

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 1.7e-07
                    E--STTTS--TTTTHHHHHHHHHHHTSEEEEEE--...-T.TTS-TTHHHHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHHHHHHHHHHHHHT CS
  Abhydrolase_3   4 fHGGGfvlgsldthdalcrelakelgavvvsvdYr...lA.PehpfPaavedalaalrwlaeqawelgadpsrivlaGdSaGGnlaaavalrarde 95 
                    fHG +   g+++   + +r++ + l++ +++v+Yr    +  e       +da +a+r+l+e+  +  ++p++i+++G S GG  + ++a + +++
     EFC36651.1 145 FHGNA---GNISHRLTNARDMYHTLKCNILMVEYRgygKStGEPSEEGLKNDAETAIRYLLEK--RSDINPNNIFIFGRSLGGAVSIYLASKYANA 235
                    55543...4444445557788889999999999995443414444455668***********9..589*********************9888776 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.44   5.7e+02     110     151 ..     108     147 ..      98     169 .. 0.64
   2 !   17.4   0.0   1.9e-06    0.0024      47     162 ..     193     315 ..     186     342 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.44
                   S.THHHCCCC--TTTCHHHHHHHHHH-CGGG-----EEEEEEE CS
  Peptidase_S9 110 l.lteeymewgnpeeneegykelspyspldnvkaypplLlihG 151
                   + + ++ +e+g++++++ +  ++ +y++  +   +p ++++hG
    EFC36651.1 108 VgISNHAEEHGKKKQKKSNV-AMMQYKKQLQ--YTPTIIMFHG 147
                   44555666777664444444.5555555444..5555566676 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 1.9e-06
                   HHHHHHHHHHHTT.S--GGGEEEEEETHHHHHHHHHHHH-GGG-SEEEEESE---CCCHHCSTTS.....THH.HCCCC--TTTCHHHHHHHHHH-C CS
  Peptidase_S9  47 Dfiaaaealakeg.yvdserlaitGgSyGGyltgaalnqrpdlFkaavaevpvvdvlrydsdtdl.....lte.eymewgnpeeneegykelspysp 136
                   D  +a+++l ++   +++++++i+G S GG ++  ++ +  +  ++++ e+ ++   +      +     + +    +  n+++ne+  + ++  ++
    EFC36651.1 193 DAETAIRYLLEKRsDINPNNIFIFGRSLGGAVSIYLASKYANAIRGVIVENTFMSIPKLIPA--IfpyrfISPiLQFFSVNKWDNEATLRNAQFRND 287
                   777899***99999************************888888888888888877665544..345566666666677899999999999999999 PP

                   GGG--..---EEEEEEETT-SSS-THHH CS
  Peptidase_S9 137 ldnvk..aypplLlihGlaDdrvppaea 162
                   +++++   + p+L+i G +D+ +p  + 
    EFC36651.1 288 YHRKRlnGDLPFLFISGRKDELIPATHM 315
                   999888889999*******999988775 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.0   3.6e-07   0.00046       2     125 ..     143     274 ..     142     348 .. 0.60

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 3.6e-07
                    EEE--GC.............GCHHHHHHHHCCTCEEEEE--TTSTS-..GGCS--HHH.CHHH.HHHHCCTT...TTSEEEEEETCHHHHHHH.HH CS
  Abhydrolase_6   2 lllHGagss........assWlvapLaallaagvhvlapDlpGhGrs..dpppldled.ladl.aalldelaa.gggpvvlvGHSlGGalala.aa 83 
                    ++ HG  ++        +++++   L       + +l++ ++G+G s  +p+  +l + +++  + ll++  + ++++++++G SlGGa++   a 
     EFC36651.1 143 IMFHGNAGNishrltnaRDMYH--TL------KCNILMVEYRGYGKStgEPSEEGLKNdAETAiRYLLEKRSDiNPNNIFIFGRSLGGAVSIYlAS 230
                    6667733222222223233333..44......47779*******96623555566666333334777777777999999**********7777444 PP

                    HCC...EEEEES-..........----TTTS----TTHHHHHHTT-CCCCH CS
  Abhydrolase_6  84 pla.lvvgvlldp........pptalpagllaaalelllallallrllawl 125
                    ++a  ++gv+++          p ++p ++++++l+++           w+
     EFC36651.1 231 KYAnAIRGVIVENtfmsipklIPAIFPYRFISPILQFFS-------VNKWD 274
                    466877888888844443222113333333333333333.......23333 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       3.2   4.1e+03      12      26 ..     138     152 ..     128     166 .. 0.57
   2 !    8.3   0.0    0.0012       1.5      75     124 ..     187     238 ..     176     249 .. 0.82
   3 ?    4.6   0.0     0.016        21     142     187 ..     294     340 ..     283     341 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.2
         DLH  12 kkpvvvviqeifGvn 26 
                   p++++++   G+ 
  EFC36651.1 138 YTPTIIMFHGNAGNI 152
                 456777776666654 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0012
         DLH  75 eekvlddlkaavayl.ksvpevstkkvgvvGfCmGGalalllaaev.pevda 124
                 ee +++d++ a++yl +++++ +++++ + G  +GGa++++la++  +++ +
  EFC36651.1 187 EEGLKNDAETAIRYLlEKRSDINPNNIFIFGRSLGGAVSIYLASKYaNAIRG 238
                 677899999999996266778899********************98455555 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.016
         DLH 142 kikapilalfgeeDefipadevekleea.lkaanvdlelkvYpgagH 187
                 +   p l++ g +De ipa ++++l e  ++  +  + +k +++ +H
  EFC36651.1 294 NGDLPFLFISGRKDELIPATHMDTLIEIyCERFGEYCYVKRFDEGTH 340
                 667899***************99998861444567777777777776 PP

>> FSH1  Serine hydrolase (FSH1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   2.3e-05     0.029     150     190 ..     277     325 ..     173     341 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.3e-05
        FSH1 150 k......yeeyyeedki..qtptLhvlGelDtvvdeerseaLaeafkns 190
                        +++ y+ +++   +p+L++ G++D++++ + + +L+e ++++
  EFC36651.1 277 AtlrnaqFRNDYHRKRLngDLPFLFISGRKDELIPATHMDTLIEIYCER 325
                 15555557888856666669*************************9986 PP

>> UPF0227  Uncharacterised protein family (UPF0227)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   2.9e-05     0.037      38     150 ..     190     312 ..     184     326 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.9e-05
     UPF0227  38 lkedpqqalkeleklvaelgddnillvGssLGGyyatrlgerfg..lrqvlln..........Palkplenlagklgeeavqstqetyvleeyhiielk 124
                 lk+d + a++ l +  +++ ++ni + G sLGG ++ +l+ ++   +r v++           Pa++p++ +++ l   +v++++++ +l + +  +  
  EFC36651.1 190 LKNDAETAIRYLLEKRSDINPNNIFIFGRSLGGAVSIYLASKYAnaIRGVIVEntfmsipkliPAIFPYRFISPILQFFSVNKWDNEATLRNAQFRN-- 286
                 56778888888888889999999******************99633666776434444444447778888887777777777777777766655543.. PP

     UPF0227 125 alelsrlkrperilvllskqDevldy 150
                   + +rl+   ++l + +++De ++ 
  EFC36651.1 287 DYHRKRLNGDLPFLFISGRKDELIPA 312
                 34455666666677777777776665 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   6.2e-05     0.079      17      86 ..     152     232 ..     144     239 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 6.2e-05
                 ----EEE-HHHH-GTT-EEEHHHHHHHH........S-HHHHHHHHHHHHHHHTT..-.EEEEEEEETHHHHHHHHHHHHH CS
    Lipase_3  17 ldfslteakellekeggkvhsgfleaye........eslreqvlkelkrllekyp..e.ysivvtGHSLGgalAlLaaldl 86 
                 + ++lt+a++ ++  ++++ +  ++ y+        e l+++ ++ ++ llek    +  +i + G SLGga+++ +a  +
  EFC36651.1 152 ISHRLTNARDMYHTLKCNILMVEYRGYGkstgepseEGLKNDAETAIRYLLEKRSdiNpNNIFIFGRSLGGAVSIYLASKY 232
                 5667788888888888999888888888999999999999**************9442478*************9888766 PP

>> Esterase  Putative esterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0     6e-05     0.077      59     137 ..     169     233 ..     120     242 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6e-05
                 EEECCCSS-TTTTTSBTTSBB.TTEEETTCCCCCCHCHHHHTHHHHHHHHHCSEECCCEEEEEETHHHHHHHHHHHCST CS
    Esterase  59 iivvvprggessfysdwdlgarfyenategpgaeayetfltqeLlplldanfrtapdgravaGqSmGGlgALilalkhp 137
                  i +v++ g                + t +p  e ++   +  +  ll+++ +++p    ++G S+GG ++++la+k+ 
  EFC36651.1 169 NILMVEYRGYG--------------KSTGEPSEEGLKNDAETAIRYLLEKRSDINPNNIFIFGRSLGGAVSIYLASKYA 233
                 45555555555..............3455555555555556666679999**************************986 PP

>> Thioesterase  Thioesterase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   0.00011      0.14       2      99 ..     141     246 ..     140     247 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00011
                   EEEEE--TTCCSGGGHHHHHHCTTC.EEEEEEECSTTST..SHHHCTTCHHHHHHHHHHHHHHH-SSS.SEE..EEEETHHHHHHHHHHHHHHHC.. CS
  Thioesterase   2 pLflfppagGsasvfrslasklsdp.vvevlavqlpgre..rdepplesieelaaeyaealrqiqpeg.Pya..lfGhSlGgllAfevArqLesq.. 90 
                   ++++f++  G++s+  + a+ +  +  + +l v+++g++  ++ep  e+++  a+  +  l++   +  P +  +fG SlGg++   +A+++ +   
    EFC36651.1 141 TIIMFHGNAGNISHRLTNARDMYHTlKCNILMVEYRGYGksTGEPSEEGLKNDAETAIRYLLEKRSDInPNNifIFGRSLGGAVSIYLASKYANAir 237
                   789*******99998888888888899*************977777777766666666666665555555542278***************999877 PP

                   T-SEEEEEE CS
  Thioesterase  91 Glavkslfl 99 
                   G  v   f+
    EFC36651.1 238 GVIVENTFM 246
                   777766666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (439 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       638  (0.0355848); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.72u 0.35s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 2449.70
//
Query:       EFC36652.1  [L=891]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    8.6e-42  143.3  20.5    8.6e-42  143.3  20.5    1.6  1  Aa_trans   Transmembrane amino acid transporter protein
  ------ inclusion threshold ------
        1.2    9.1   4.2         12    5.9   0.2    3.4  3  DUF1676    Protein of unknown function (DUF1676)


Domain annotation for each model (and alignments):
>> Aa_trans  Transmembrane amino acid transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.3  20.5   9.6e-46   8.6e-42       4     379 ..     385     824 ..     382     837 .. 0.91

  Alignments for each domain:
  == domain 1  score: 143.3 bits;  conditional E-value: 9.6e-46
    Aa_trans   4 salsavlnlikaivGaGvLaLPyAfkqlGlivGlillllvallslytlllLvkcsktlasgkrnksYgdlgyrllGpkgkliidlailvqlfGvgvsyl 102
                 ++  +v nli+ +v+  +++  y+++q G+ + +++l++va l ++tl +L +++      ++  s+  l+++++G  g+++i   i++++fG+++s l
  EFC36652.1 385 NIAFGVYNLINDVVSPATISSGYTVAQSGIGAYVLTLVIVACLIFFTLIILYDMANA----QKVTSFPSLIKKTFGNIGYILICIFIFLFNFGAVCSEL 479
                 5566899************************************************84....79************************************ PP

    Aa_trans 103 iligdllpaifesffdt..lllsnvyfilisaliiipLslipnlskLsylSllalvsslyyivilvlvvaelvklelkgvseetvkkasklkglflaig 199
                 i i++ lp ++  + ++    +s++ + + +++i++p + +++ls+++y+Sl+++ s+++   i +l ++el+ ++ ++v +++++ ++   ++++a+g
  EFC36652.1 480 IEISQILPDLLYELIGKesVFISRYAVLVYVTIILLPIASMKQLSSFKYASLISVTSVAL---ISILLTYELGLGR-RKVPYNDSVFDFLRPQYLSAMG 574
                 ***********99998888999************************************85...7888888888776.66888888899999******** PP

    Aa_trans 200 iivFAftghavlleiqnelkdpskfkkmtkvlllsiilatvlyilvGlvGYltFGn.evkg.nillnlpkssilivivnlllvlhlilsfplqlhplrq 296
                 ++ F f++h v +e++ +lk++s  k  + ++    +la+ + +++Gl+ +l F + + k+ n+l  lpk+  l +++++ll+  l ls++  ++  r 
  EFC36652.1 575 TLSFVFVCHDVSFEVIGSLKNNSR-KRYMILVFCMLLLAVGVLLFMGLSSFLLFFDvNLKDaNVLDLLPKNYGLAILARILLCASLGLSISYTCFMPRF 672
                 ************************.87888888888888889999******99887467779*********99************************** PP

    Aa_trans 297 vvenllikk.....................................................................eavagasekeapkskllrlvi 326
                 +++ +++++                                                                      a++      ++ +  l++ +
  EFC36652.1 673 ALKSVIKTIlqqfdevkqqkeqfktkpftsepsdentvteseltvvsagkdseeedaattsvnetsptsentkhknavLASISRFFATRTGKDALHYGT 771
                 ******999*******************************************************9999988888776544444444444444456**** PP

    Aa_trans 327 rlllvvityliAlsvpslakvlslvGatsstplsfilPalfhlkliktekksl 379
                 +l++v+++ ++A++v +l+ +++l+Ga+s+t++++i+P+l+++ l + e k +
  EFC36652.1 772 TLIVVLSAFIVAILVENLGVIIGLTGAISATTIAYIFPSLTYIVLERRERKEM 824
                 *******************************************9998887765 PP

>> DUF1676  Protein of unknown function (DUF1676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.12   1.1e+03      23      99 ..     318     402 ..     309     435 .. 0.70
   2 ?    1.8   0.2     0.025   2.2e+02     119     147 ..     596     624 ..     582     628 .. 0.71
   3 ?    5.9   0.2    0.0013        12      29      82 ..     709     762 ..     702     770 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.12
     DUF1676  23 ldkdeielvdgvslvrneeaasassk.........eeeeelsreeeeare............eelekllleklerflkshslevklpeeldaegaees 99 
                 +++dei+ + +v l ++ +++++ s+         +             +             + +++  e+l+r ++ +++ + + ++++ +++  +
  EFC36652.1 318 FKNDEISTFKDVDLNQEVSDEDDGSShrdsidtnrK-------------SvelllkdiptstGKSDDFHRERLWRHFTKTNIAFGVYNLINDVVSPAT 402
                 677888888888888876665544333333333322.............1334555555555688889999999988888888888777665655555 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.025
     DUF1676 119 kklkkmllplllalklklklLlplalgll 147
                 + +k +++    +l l +++Ll+++l  +
  EFC36652.1 596 NSRKRYMILVFCMLLLAVGVLLFMGLSSF 624
                 34455666666667799999999998655 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0013
     DUF1676  29 elvdg.vslvrneeaasasskeeeeelsreeeeareeelekllleklerflkshs 82 
                 +++++ +++v+  ++++++++  + + ++ ++ +++++ ++++l +++rf+++++
  EFC36652.1 709 TVTESeLTVVSAGKDSEEEDA-ATTSVNETSPTSENTKHKNAVLASISRFFATRT 762
                 667666999999988777664.445555557788889****************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (891 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1702  (0.09493); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.31s 00:00:01.08 Elapsed: 00:00:00.50
# Mc/sec: 5397.32
//
Query:       EFC36653.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.9   0.1       0.26   11.7   0.1    1.6  1  HMG_box   HMG (high mobility group) box


Domain annotation for each model (and alignments):
>> HMG_box  HMG (high mobility group) box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   1.4e-05      0.26      25      53 ..      20      48 ..       8      50 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.4e-05
                TS-HHHHHHHHHHHHHHSHHHHHHHHHHH CS
     HMG_box 25 elknaeiskklgekWkalseeeKkkYeek 53
                ++k + is    ++W++l+++eK+ Y + 
  EFC36653.1 20 NIKPRKISDYNQKRWNSLTDAEKRIYNDN 48
                688999999999**************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       718  (0.0400469); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 2314.29
//
Query:       EFC36654.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-41  142.6   0.1      2e-41  142.1   0.1    1.3  1  Pkinase         Protein kinase domain
    3.6e-21   75.6   0.0    5.4e-21   75.0   0.0    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
    1.3e-05   24.7   0.0    1.7e-05   24.3   0.0    1.2  1  Kinase-like     Kinase-like
    0.00056   19.6   0.8      0.058   13.0   0.0    2.6  3  FTA2            Kinetochore Sim4 complex subunit FTA2
     0.0041   16.0   0.0     0.0062   15.4   0.0    1.2  1  Pkinase_fungal  Fungal protein kinase
     0.0094   16.3   0.0      0.022   15.2   0.0    1.6  1  Ret2_MD         RNA editing 3' terminal uridylyl transferase 
  ------ inclusion threshold ------
       0.25   11.2   0.1       0.36   10.7   0.1    1.2  1  APH             Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.1   0.1   7.9e-45     2e-41       5     259 ..      28     267 ..      25     294 .. 0.88

  Alignments for each domain:
  == domain 1  score: 142.1 bits;  conditional E-value: 7.9e-45
                 EEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHH..HHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHH CS
     Pkinase   5 eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrE..ikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseeeak 101
                 + +G+G+fG+Vyk+    +++ +A+K ++  ++++ +ek +++E  i+ ++ +kh+++++++e fe + +ly+v ++++ ++l+++     +l+e ++ 
  EFC36654.1  28 TLVGSGGFGCVYKVD--VSENCYAIKAVDFVEDNQISEKPTRSEvvIEAMRDFKHERLLNIMERFEVDYTLYMVSNFCKYETLEQIGG-YLKLDEYHCL 123
                 679**********99..78899****************999**94446699999*************************999999886.588******* PP

                 HHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE..TTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHHHHHHSS-S CS
     Pkinase 102 kiakqilegleylHskgiiHrDlKpeNiLid..ekgelKitDFGlakelessskltsfvgtseYlAPEvl..keneyskkvDvWslGvilyelltgkpp 196
                  i++q+legleylHs+++iHrD+Kp+N+L++  +   + ++DFGl  + + +  +++++gt +Yl+PE+   ++++++ ++D++slG+++++++  +  
  EFC36654.1 124 LILNQLLEGLEYLHSQKLIHRDIKPSNVLVEsiDPTRVILADFGLLLHEHGNR-ADQMCGTLYYLPPEISptGGKRFTFAADIYSLGLTIISMMGVHIQ 221
                 *******************************53344499******98888766.***************99899************************* PP

                 TTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 197 fsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                 f+  +++ +v+ ++ q                 ++++s+  +d+l ++++  p+ R  +   l
  EFC36654.1 222 FP--RTSLTVKGQVIQ---------------GLREKLSKATIDILLDMIHPSPSLRANFCTNL 267
                 **..222222222222...............34678999999999999999999999865544 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.0   0.0   2.1e-24   5.4e-21       6     200 ..      29     217 ..      25     296 .. 0.81

  Alignments for each domain:
  == domain 1  score: 75.0 bits;  conditional E-value: 2.1e-24
                  EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHH CS
  Pkinase_Tyr   6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekltlk 103
                   +G+G fG V++  ++   e+     av  +++++ +e+ ++    ++ m+++kh+++++++     + +l++v +++k+ +L++        kl+  
   EFC36654.1  29 LVGSGGFGCVYKVDVS---ENCYAIKAVDFVEDNQISEKPTRSEVVIEAMRDFKHERLLNIMERFEVDYTLYMVSNFCKYETLEQIGGYL---KLDEY 120
                  68************99...333344466666666655555555556789**********************************9976555...89999 PP

                  HHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE..TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..EEHHHHHHHHHHHHHH CS
  Pkinase_Tyr 104 dllsfalqvAkGmeyLeskklvHrdlaarNvLlse..nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwE 197
                  + l +  q+ +G+eyL+s+kl+Hrd+   NvL+++   + v ++DfGL  +     + +++++    + +++pE+  ++   ft ++D++s G +++ 
   EFC36654.1 121 HCLLILNQLLEGLEYLHSQKLIHRDIKPSNVLVESidPTRVILADFGLLLHE----HGNRADQMCGTLYYLPPEISPTGGkrFTFAADIYSLGLTIIS 214
                  99********************************865779********9866....4455666677899*****98765444*************998 PP

                  HHT CS
  Pkinase_Tyr 198 ift 200
                  ++ 
   EFC36654.1 215 MMG 217
                  875 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   0.0   6.6e-09   1.7e-05     139     247 ..     116     219 ..      43     253 .. 0.78

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 6.6e-09
  Kinase-like 139 kkletiarlllTlqlirlaanLqakglvhgkftvdnlllde..kgglmlggftaLvr.agtkvvlseve..kgfaPpEllgsrggytrknktkmthkl 231
                  k  e+++ l+l  ql+    +L+++ l+h ++++ n+l +     +++l +f+ L    g+++   +++    + PpE+    g        ++t++ 
   EFC36654.1 116 KLDEYHCLLIL-NQLLEGLEYLHSQKLIHRDIKPSNVLVESidPTRVILADFGLLLHeHGNRAD--QMCgtLYYLPPEISPTGG-------KRFTFAA 203
                  55688999999.89************************98622689*******98761566666..555235689****99944.......48***** PP

  Kinase-like 232 daWqlGlviyriwclk 247
                  d + lGl+i ++  ++
   EFC36654.1 204 DIYSLGLTIISMMGVH 219
                  ***********98765 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.0   2.2e-05     0.058      28      81 ..      28      78 ..      11      93 .. 0.72
   2 ?    4.4   0.0      0.01        26     178     204 ..     126     152 ..     115     157 .. 0.89
   3 ?   -2.2   0.0         1   2.6e+03     172     203 ..     268     299 ..     264     301 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.2e-05
        FTA2 28 eyLgkglhsiVlkvkirgkeYALKlFrfleaeeleeaeedlkiprealkelasy 81
                 ++g+g  ++V+kv++ ++ YA+K   f+e+++ +   e+ ++++ ++++++++
  EFC36654.1 28 TLVGSGGFGCVYKVDVSENCYAIKAVDFVEDNQIS---EKPTRSEVVIEAMRDF 78
                56699999****************99999776655...3333333444444333 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.01
        FTA2 178 lpkllrdlkklhklgIvvrDlkeenyi 204
                 l++ll+ l+ lh++ +++rD+k++n++
  EFC36654.1 126 LNQLLEGLEYLHSQKLIHRDIKPSNVL 152
                 6899*******************9986 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 1
        FTA2 172 elevsqlpkllrdlkklhklgIvvrDlkeeny 203
                 +++v+q+ k l+++++l +   +  D++e ++
  EFC36654.1 268 KKRVNQVMKTLENTENLYQNRQMYEDIEETAF 299
                 56788888889999988888888888887766 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   2.4e-06    0.0062     308     381 ..     122     187 ..     114     208 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.4e-06
  Pkinase_fungal 308 llealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFm 381
                     +l  l + ++g++ L+  ++++HrDi   N+l+    + +  + +L+D+ l  +++  ++++   +  GTl+++
      EFC36654.1 122 CLLILNQLLEGLEYLH-SQKLIHRDIKPSNVLVE---SIDPTRVILADFGLLLHEHG-NRAD---QMCGTLYYL 187
                     5667888899******.9**************99...6678999*******999995.3333...478888876 PP

>> Ret2_MD  RNA editing 3' terminal uridylyl transferase 2 middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   8.4e-06     0.022      24      89 ..      12      80 ..       6      84 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 8.4e-06
     Ret2_MD 24 keleyiaeklgrenvegiyverttyGcriaiqvsskeqaieaigllPdGkiltkgmredyt....rdvld 89
                k  ++i++k+g + v+ + v   ++Gc  +++vs +  ai a+ ++ d +i  k  r + +    rd++ 
  EFC36654.1 12 KHHDDILNKFGLD-VNITLVGSGGFGCVYKVDVSENCYAIKAVDFVEDNQISEKPTRSEVVieamRDFKH 80
                5668899999987.57789999********************************9998753222266665 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   0.00014      0.36     164     194 ..     137     167 ..     108     173 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00014
                 S-EEEE-SS-SGGGEEEC...TTEEEEE---T CS
         APH 164 lptvllHgDlhpgNllvd.pddgrvtGviDfe 194
                  ++ l+H+D++p N+lv+  d++rv  + Df+
  EFC36654.1 137 HSQKLIHRDIKPSNVLVEsIDPTRV-ILADFG 167
                 46779*************8677776.233665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       918  (0.051202); expected 358.6 (0.02)
Passed bias filter:                      627  (0.0349713); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2121.27
//
Query:       EFC36655.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.4e-39  135.3   0.0    3.8e-39  134.6   0.0    1.3  1  Pkinase         Protein kinase domain
    2.6e-21   76.1   0.0      4e-21   75.5   0.0    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
      0.002   17.1   0.1     0.0035   16.4   0.0    1.4  2  Haspin_kinase   Haspin like kinase domain
     0.0029   16.5   0.0      0.004   16.0   0.0    1.3  1  Pkinase_fungal  Fungal protein kinase
     0.0055   17.1   0.1      0.016   15.6   0.1    1.8  1  Rpn3_C          Proteasome regulatory subunit C-terminal
  ------ inclusion threshold ------
      0.035   13.5   0.0      0.061   12.7   0.0    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  134.6   0.0   1.3e-42   3.8e-39       3     261 ..      66     315 ..      64     320 .. 0.86

  Alignments for each domain:
  == domain 1  score: 134.6 bits;  conditional E-value: 1.3e-42
                 EEEEEEEESSEEEEEEEE..TTTTEEEEEEEEECHCHCHHHH..HHHHHHHHHHHHHS....CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHS CS
     Pkinase   3 kleklGeGsfGkVykave..ketgkivAvKkikkekakkkke..kkvlrEikilkklk....hpnivrlyevfeekdelylvleyveggeladllerkg 93 
                 ++e +G G+fG+Vyk     ++t + vA+K i+  +++ k+e  k+  +  +++k+ +    hp+++ ++++fee+++ly+v  +  gg+l++     +
  EFC36655.1  66 VIEPIGAGGFGTVYKTQIpfDNTIHNVAIKAIEFAEDNPKSEseKQKPSRRQVMKEANrvfvHPRLLYVMDSFEEDKTLYIVSPFYAGGSLEKN----Q 160
                 5789**********986422677889******988888777777888899999999988999***************************77665....5 PP

                 S--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE..EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHH CS
     Pkinase  94 slseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge..lKitDFGlakelessskltsfvgtseYlAPEvl..keneyskkvDvWslGvily 188
                 +++e+ +  i++q+le+le lH++  iHrD+Kp+Ni++ +++   + ++D+Gl + +++ + +t f+gt+++ APE+   + ++y++k+D++s G++ +
  EFC36655.1 161 VIEERSCLIILEQVLEALEVLHANDYIHRDIKPHNIFVRNSNPidVVLGDYGLLRSVHTLK-TTGFCGTKYFTAPEIKgtDVSSYTNKSDIYSTGMTAL 258
                 7**************************************6555779*************88.***************9766699**************9 PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTS CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqh 261
                  l  g  +    ++++++++++ +                  +++s+e ++l+ ++++ +++kR+ a+++ q+
  EFC36655.1 259 RL-LGVIISD-PRTTTTFKSQVVN--------------GLASRNVSRETTELILQMVHPNRRKRPNATQARQQ 315
                 99.6777777.3444434443333..............2456899***********************99875 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.5   0.0   1.3e-24     4e-21       4     256 ..      67     313 ..      65     316 .. 0.77

  Alignments for each domain:
  == domain 1  score: 75.5 bits;  conditional E-value: 1.3e-24
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEE...STTSSHHHHHHHHHHHHHHHTS-....BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHH CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtl...keeateeekeelleeakimkklk....hpnivkllgvctkeepllivteyvkgGdLlkfLrk 94 
                   + +G+G fG+V++ ++    +++  +Va+K +   +++ ++e++++  +  ++mk+ +    hp+++ ++    ++++l+iv  + +gG+L+k    
   EFC36655.1  67 IEPIGAGGFGTVYKTQIP--FDNTIHNVAIKAIefaEDNPKSESEKQKPSRRQVMKEANrvfvHPRLLYVMDSFEEDKTLYIVSPFYAGGSLEK---- 158
                  678**************9..8889999****99443233333334555556777776422333999******999****************974.... PP

                  TCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETT..EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..EEHHHHH CS
  Pkinase_Tyr  95 kekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenk..vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk..ftsksDv 188
                    ++ ++ ++ l +  qv +++e L++++++Hrd+   N+++++++   v ++D+GL r++    ++ k+++      ++apE+  + +  +t ksD+
   EFC36655.1 159 --NQVIEERSCLIILEQVLEALEVLHANDYIHRDIKPHNIFVRNSNpiDVVLGDYGLLRSV----HTLKTTGFCGTKYFTAPEIKGTDVssYTNKSDI 250
                  ..47899999*********************************987446788*********....444444444455567***97666566******* PP

                  HHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 189 WsfGvllwEiftlgespypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselv 256
                  +s G++   ++          +++++ +++ +g    + +++++e +el+ +  + + ++Rp+ ++ +
   EFC36655.1 251 YSTGMTALRLLG--VIISDPRTTTTFKSQVVNGL---ASRNVSRETTELILQMVHPNRRKRPNATQAR 313
                  *****9988775..33333345555666666664...4456778889999999999999999877765 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   1.2e-06    0.0035     150     256 ..     113     216 ..      30     228 .. 0.68
   2 ?   -3.7   0.0       1.4   4.3e+03     164     178 ..     295     309 ..     271     334 .. 0.46

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.2e-06
  Haspin_kinase 150 lkslklvkgtypglllllqdkvlkekpdfyseqqlflvlllkdkGtdLeevklkswkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdkn.. 243
                        +++k + + + +  +  +++++  f++++ l++v  + ++G +Le+ ++ + + +l i+ q+++ L v  ++ ++ HRd++  ni v+++  
     EFC36655.1 113 PSRRQVMKEA-NRVFVHPRLLYVMDS--FEEDKTLYIVSPF-YAGGSLEKNQVIEERSCLIILEQVLEALEVLHAN-DYIHRDIKPHNIFVRNSnp 203
                    4444556666.555555555566665..6666667776666.56778*************************9887.899************9855 PP

  Haspin_kinase 244 lnvtlidlklsRl 256
                      v l d+ l R 
     EFC36655.1 204 IDVVLGDYGLLRS 216
                    6778889988876 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.4
  Haspin_kinase 164 llllqdkvlkekpdf 178
                    +l +     +++p+ 
     EFC36655.1 295 ILQMVHPNRRKRPNA 309
                    332222222222221 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   1.3e-06     0.004     281     343 ..     118     201 ..      29     249 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 1.3e-06
  Pkinase_fungal 281 r....................lenrvhrrlvispvGkpiekae..spkellealrDaIkghrsLflkagiLHrDiSenNilitds 343
                                           e++++ ++    +G ++ek +  + + +l  l++++++++ L+    ++HrDi  +Ni + +s
      EFC36655.1 118 VmkeanrvfvhprllyvmdsfEEDKTLYIVSPFYAGGSLEKNQviEERSCLIILEQVLEALEVLH-ANDYIHRDIKPHNIFVRNS 201
                     13344445566666666666434444443333446888887762256779***************.9*************99954 PP

>> Rpn3_C  Proteasome regulatory subunit C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.1   5.4e-06     0.016      13      52 ..      80     118 ..      77     126 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 5.4e-06
      Rpn3_C  13 deRIkFclqlHneavkAMRYpedakkkelesaeearerqq 52 
                 ++ I F +++Hn a+kA+ + ed+ k+e e+++ +r++  
  EFC36655.1  80 KTQIPFDNTIHNVAIKAIEFAEDNPKSESEKQKPSRRQ-V 118
                 5669999*********************9999998887.2 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   2.1e-05     0.061     118     155 ..     165     202 ..     155     212 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2.1e-05
         Kdo 118 elkrallkavgrliaklhragvnHadlyaknillqqee 155
                 ++   +l++v  + + lh+ +  H+d+ ++ni++++ +
  EFC36655.1 165 RSCLIILEQVLEALEVLHANDYIHRDIKPHNIFVRNSN 202
                 555568999999**********************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       590  (0.0329076); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2275.44
//
Query:       EFC36656.1  [L=468]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-43  145.5  26.2    1.4e-13   50.4   0.1   10.4 12  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.1   1.6e-06     0.029      15      47 ..      23      56 ..      18      58 .. 0.90
   2 !   14.4   0.5   1.3e-06     0.024       1      36 [.      34      70 ..      34      87 .. 0.82
   3 !    4.1   0.9    0.0021        38       9      40 ..      71     106 ..      60     109 .. 0.57
   4 !    8.6   0.7   8.6e-05       1.5       1      40 [.      92     129 ..      92     138 .. 0.87
   5 !   45.1   0.5   3.3e-16     6e-12       1      48 [.     140     187 ..     140     188 .. 0.98
   6 !   21.3   0.1   8.8e-09   0.00016       1      48 [.     190     239 ..     190     240 .. 0.91
   7 !   23.5   0.0   1.9e-09   3.4e-05       3      49 .]     219     262 ..     218     262 .. 0.93
   8 !   50.4   0.1   7.6e-18   1.4e-13       8      49 .]     246     287 ..     241     287 .. 0.98
   9 !   32.4   0.0     3e-12   5.4e-08       1      37 [.     264     300 ..     264     303 .. 0.93
  10 !   11.1   0.1   1.4e-05      0.25       5      39 ..     313     348 ..     312     353 .. 0.91
  11 !    2.1   0.0    0.0087   1.6e+02      23      37 ..     356     370 ..     355     391 .. 0.78
  12 !    2.2   0.0    0.0083   1.5e+02       3      39 ..     412     448 ..     410     468 .] 0.73

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.6e-06
     DUF4116 15 alkylseeLknDkeivlkAvkqng.talsyasee 47
                a+ y++ e+ +D+e vl+ +k+ng ++l+ +++e
  EFC36656.1 23 AFGYIPIEFYKDREYVLASIKKNGsHCLYDIHPE 56
                6789*****9**************7799998876 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.3e-06
     DUF4116  1 DrEivleavkkngs.alkylseeLknDkeivlkAvkq 36
                DrE vl  +kkngs +l+ + +e  +D+ei+ + +k+
  EFC36656.1 34 DREYVLASIKKNGShCLYDIHPEAFSDREILFEMLKS 70
                9***********9879999*999889****7776664 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.0021
     DUF4116   9 vkkngsalkylsee....LknDkeivlkAvkqngta 40 
                 +k++++a   +++e    + nD+eiv+  +  ++++
  EFC36656.1  71 LKNDNFASVPIDNEilkpFANDREIVKLLIHLDSSF 106
                 334444444444445555689****99988777665 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 8.6e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 DrEiv+ ++  ++s + +   ++k D+e +l A+ +++++
  EFC36656.1  92 DREIVKLLIHLDSSFFDN--QKFKFDREMALLACISCSDN 129
                 99*********9998887..99**************9964 PP

  == domain 5  score: 45.1 bits;  conditional E-value: 3.3e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D+E+vl a++ n s+++  s++LknDk ++ kA+k+ng++++ +s+eL
  EFC36656.1 140 DEEFVLSAIEENYSVFNTTSDKLKNDKAFIRKALKRNGKVIYELSDEL 187
                 9**********************************************9 PP

  == domain 6  score: 21.3 bits;  conditional E-value: 8.8e-09
     DUF4116   1 DrEivleavkkngsalkyl..seeLknDkeivlkAvkqngtalsyaseeL 48 
                 D+E+++ a+++n+++++ +  +e++ +  ++++ Av++ng  l ++ e+L
  EFC36656.1 190 DEELIKIAIEQNPMVFEAIyeNESINCGADVIKMAVEKNGQLLQFVTEDL 239
                 9*************888763367799999******************998 PP

  == domain 7  score: 23.5 bits;  conditional E-value: 1.9e-09
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++++ av+kng  l+++ e+L n   +   Avkqn+ al+yas+ L+
  EFC36656.1 219 DVIKMAVEKNGQLLQFVTEDLEN---FDRIAVKQNPLALDYASDQLK 262
                 79*****************9976...7778**************997 PP

  == domain 8  score: 50.4 bits;  conditional E-value: 7.6e-18
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 avk+n++al y+s+ LknD++ vl+Avk++g+++ yaseeLr
  EFC36656.1 246 AVKQNPLALDYASDQLKNDRDSVLEAVKKDGSCFVYASEELR 287
                 9****************************************8 PP

  == domain 9  score: 32.4 bits;  conditional E-value: 3e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 Dr+ vleavkk+gs++ y+seeL+++  +v + + ++
  EFC36656.1 264 DRDSVLEAVKKDGSCFVYASEELRSNSSFVQEVIDNC 300
                 8999**************************9988766 PP

  == domain 10  score: 11.1 bits;  conditional E-value: 1.4e-05
     DUF4116   5 vleavkkngsalkylseeLkn.DkeivlkAvkqngt 39 
                  l ++k  g++ + + e L+n Dke++l++v ++g 
  EFC36656.1 313 LLLILKEKGYCPTSVYEALRNiDKELALRIVSIHGE 348
                 68899*****************************96 PP

  == domain 11  score: 2.1 bits;  conditional E-value: 0.0087
     DUF4116  23 LknDkeivlkAvkqn 37 
                 ++nD++++l A + +
  EFC36656.1 356 WQNDRDVLLTAFETC 370
                 578999998888765 PP

  == domain 12  score: 2.2 bits;  conditional E-value: 0.0083
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 E+   +++++gsa++  + ++k    ++ +A kq+g+
  EFC36656.1 412 ELLRRLLQIDGSAFRLMDGKFKDEPILIEEAWKQSGY 448
                 7788899999999999999999888888889888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       655  (0.036533); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 3001.90
//
Query:       EFC36657.1  [L=465]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.096   12.9   0.3       0.26   11.5   0.3    1.7  1  Glutaredoxin  Glutaredoxin
       0.15   12.3   0.0        1.3    9.3   0.0    2.2  2  DUF2063       Putative DNA-binding domain


Domain annotation for each model (and alignments):
>> Glutaredoxin  Glutaredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.3   2.9e-05      0.26       6      41 ..     362     395 ..     357     403 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.9e-05
                   STSSHHHHHHHHHHHHTTGGEEEEEGCCSHHHHHHH CS
  Glutaredoxin   6 kptCpyCkkakrlLkelgvkfeeidvdkdeeireel 41 
                   k tC yC++a ++Lk+    ++e+ + ++e++r+ +
    EFC36657.1 362 KCTCDYCQMATQFLKNPH--VTEYKLQENEKLRKHV 395
                   679************997..8899999999888766 PP

>> DUF2063  Putative DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.13   1.2e+03      17      50 ..      65      99 ..      39     122 .. 0.62
   2 ?    9.3   0.0   0.00014       1.3      31      65 ..     142     176 ..     140     187 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.13
                ..XXXXXX--HHHHHHHHHHHHHHHH.HTTTGGGG CS
     DUF2063 17 pglsaakrlavYrnlvfnnlieaLaa.aFpvlral 50
                 +l++a +l+ Yr+ v+  l+++ a+ a+  l+++
  EFC36657.1 65 VALIKAFGLETYRERVMDLLVKCKANlAYGFLQEI 99
                34555569999999999988887555245555555 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00014
                 HHHHHHHHHHHHHTTTGGGGS-HHHHHHHHHHHHH CS
     DUF2063  31 lvfnnlieaLaaaFpvlrallGeerfdalarayir 65 
                  ++ n+++ +++ F+++++l  + +f+a++++y+r
  EFC36657.1 142 KMLSNWYGDVQDLFEMAKRLKDKNCFNAVLEKYFR 176
                 56778899999**********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (465 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       949  (0.052931); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.35s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2759.07
//
Query:       EFC36658.1  [L=148]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (148 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       754  (0.0420548); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.42u 0.27s 00:00:00.69 Elapsed: 00:00:00.43
# Mc/sec: 1027.81
//
Query:       EFC36659.1  [L=408]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0012   18.8   0.2     0.0028   17.6   0.0    1.8  2  Acetyltransf_10  Acetyltransferase (GNAT) domain
  ------ inclusion threshold ------
      0.033   14.2   0.0      0.084   12.9   0.0    1.6  1  FR47             FR47-like protein
      0.048   13.9   0.0       0.11   12.7   0.0    1.7  1  Acetyltransf_1   Acetyltransferase (GNAT) family


Domain annotation for each model (and alignments):
>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.2   7.4e+03       5      35 ..      52      81 ..      44     102 .. 0.52
   2 !   17.6   0.0   4.6e-07    0.0028      60     111 ..     289     341 ..     225     344 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.2
  Acetyltransf_10  5 yseegietfkefispealrerieegealllv 35
                     ++ee+i++  ++i++  l  +  ++++++++
       EFC36659.1 52 MNEEEIDETLRYIENPYLVVEN-KPDTHFML 81
                     4455555554555543333333.44444333 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 4.6e-07
  Acetyltransf_10  60 dpeyrgqGigkaLleaveeeaekdgikl.eltvnaspyavpfYeklGFkavge 111
                      dp+ r+ G ++ L  ++  e+ +++++l   t+++s++a ++Y++lGF+ +g+
       EFC36659.1 289 DPAIRRMGSARLLSYHAVFEIGQEELNLkYCTLQSSKAAFNLYKQLGFEHIGD 341
                      7999****************999999999********************9875 PP

>> FR47  FR47-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   1.4e-05     0.084      30      80 ..     289     339 ..     266     345 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.4e-05
                 -GGG-SSSHHHHHHHHHHHHHHHS-S-EEEEEETT-HHHHHHHHHHT-EEE CS
        FR47  30 lpehrrrGlgsrlvkalakeiaergktvllvvvasNtpsirlyeklGfeki 80 
                 +p  rr+G +++l      ei +++ ++   + +s +++ +ly++lGfe i
  EFC36659.1 289 DPAIRRMGSARLLSYHAVFEIGQEELNLKYCTLQSSKAAFNLYKQLGFEHI 339
                 5789********************************************987 PP

>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.8e-05      0.11      44     117 .]     264     336 ..     214     336 .. 0.65

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.8e-05
                     EEEEEEEEEEETTSTTEEEEE..EEEESGGGTTSSHHHHHHHHHH.HHHHHT.TESEEEEEEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  44 liGfisllkipdekggvayie..slaVspeyrgkGlGsaLleale.eraree.gikkivlaveedndaairlYeklGF 117
                      i  ++l+   +  + v+ ++  + + +p+ r++G +++L  +++ e+  ee ++k  ++ + ++ +aa +lY++lGF
      EFC36659.1 264 MISVATLFVEKE--KSVCGLYnvGTVKDPAIRRMGSARLLSYHAVfEIGQEElNLK--YC-TLQSSKAAFNLYKQLGF 336
                     444444444444..2222222114444*************8888846666554443..55.558899******66**9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (408 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1409  (0.0785878); expected 358.6 (0.02)
Passed bias filter:                      753  (0.041999); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.48
# Mc/sec: 2532.81
//
Query:       EFC36660.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1599  (0.0891851); expected 358.6 (0.02)
Passed bias filter:                      426  (0.0237604); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.42
# Mc/sec: 2799.35
//
Query:       EFC36661.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1134  (0.0632495); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.24s 00:00:00.83 Elapsed: 00:00:00.44
# Mc/sec: 3321.47
//
Query:       EFC36662.1  [L=784]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-14   54.5   6.0    2.4e-14   53.6   4.8    2.1  1  RGS             Regulator of G protein signaling domain
     0.0002   21.6   0.0    0.00039   20.7   0.0    1.5  1  HAMP            HAMP domain
  ------ inclusion threshold ------
      0.037   13.4   1.5       0.17   11.2   0.0    2.3  2  Zn_peptidase_2  Putative neutral zinc metallopeptidase
      0.099   12.4   1.9        3.8    7.2   0.1    2.5  2  Claudin_2       PMP-22/EMP/MP20/Claudin tight junction
       0.19   12.2   2.6       0.58   10.7   2.6    1.8  1  DUF4706         Domain of unknown function (DUF4706)
       0.34   11.1   1.2        1.3    9.2   0.2    2.3  2  Shisa           Wnt and FGF inhibitory regulator
       0.58   10.6   6.5      0.081   13.3   0.8    2.4  3  DUF805          Protein of unknown function (DUF805)
        3.4    8.0   9.1       0.53   10.6   0.7    3.1  3  DUF948          Bacterial protein of unknown function (DUF948
        7.3    6.7   9.6          2    8.5   3.3    2.6  2  Herpes_UL73     UL73 viral envelope glycoprotein


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.6   4.8   1.2e-17   2.4e-14       2     111 ..     640     749 ..     639     752 .. 0.94

  Alignments for each domain:
  == domain 1  score: 53.6 bits;  conditional E-value: 1.2e-17
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqeevfel 100
                 +++ + d+ +r+ F+eF+ +e +een+ F+++v e+kk +  +e+ kk keI++ +l+++s++ +ni+k+++++  k++ +   + +lf+++++ + ++
  EFC36662.1 640 FDRYMTDPILRQQFKEFCTKERAEENVIFLEQVMEYKKLSRTHERAKKQKEIIEMFLSENSATPINISKQVFTTEVKKILEGFGQLQLFDNLETIIKSM 738
                 6777899***************************************************************998766666666999************** PP

                 HHHHHHHHHHT CS
         RGS 101 lekdsypkFlk 111
                 l  d +++F++
  EFC36662.1 739 LILDKFKRFIS 749
                 *********86 PP

>> HAMP  HAMP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0     2e-07   0.00039       5      52 ..     420     468 ..     416     469 .. 0.93

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 2e-07
                 TTHHHHHHHHHHHHHHTTT.BTSSTCCTTSSSHHHHHHHHHHHHHHHHH CS
        HAMP   5 rilrPLrrLaraarriaaG.dldtrlpvsgrDEiGeLarafNaMldrLr 52 
                  +lr++  L+++++r+ +  ++  r p  g+DE+G+L + +N+Ml +++
  EFC36662.1 420 IVLRRVISLSSTVQRVHDTvNYAIRAPKLGNDELGQLSKDLNTMLGEIE 468
                 58999************9999999*********************9987 PP

>> Zn_peptidase_2  Putative neutral zinc metallopeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   8.7e-05      0.17     120     181 ..      37      97 ..      17     102 .. 0.72
   2 ?    0.2   0.3       0.2   4.1e+02     124     158 ..     392     426 ..     371     456 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.7e-05
  Zn_peptidase_2 120 igsklslillliglllslsslllligiilfalavlfqlvtLPvEfdASkrAlk.iLeeegils 181
                     ++ ++ + ++li ++l l+   l +gi+l a+ v+fq v +    +ASkr  + +L++ ++l+
      EFC36662.1  37 FSLRVKTTFVLIIMFLGLM--ALCLGILLAAFFVVFQNVEYQQAKEASKRVSRaLLDDLNYLQ 97 
                     4444445555555555333..699************************886551555666665 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.2
  Zn_peptidase_2 124 lslillliglllslsslllligiilfa.lavlfqlv 158
                     ++ +l++ ++++ +  +++ i+i++f+ ++vl  ++
      EFC36662.1 392 MASFLVVWSVMTFMI-VVMSIAIVCFVeMIVLRRVI 426
                     333333333333222.25555555554144444444 PP

>> Claudin_2  PMP-22/EMP/MP20/Claudin tight junction
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.1    0.0019       3.8      86     119 ..      40      73 ..       5      90 .. 0.80
   2 ?    4.1   0.2     0.018        35      82     111 ..     388     417 ..     324     439 .. 0.54

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0019
   Claudin_2  86 lalarfvqvlliLslvlivlavvlgllallkqsv 119
                    + fv ++++L+l++++l+++l+  ++++q+v
  EFC36662.1  40 RVKTTFVLIIMFLGLMALCLGILLAAFFVVFQNV 73 
                 456789999**************99999999886 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.018
   Claudin_2  82 atsllalarfvqvlliLslvlivlavvlgl 111
                  ++ +a + +v +++++ +v++ +a+v+++
  EFC36662.1 388 FQIGMASFLVVWSVMTFMIVVMSIAIVCFV 417
                 233333444455566666666666666665 PP

>> DUF4706  Domain of unknown function (DUF4706)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   2.6   0.00029      0.58      14      80 ..     614     681 ..     608     703 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00029
     DUF4706  14 medkeeikekyepewerlspkeqdelideslvkpevrakyke.esserekeelfpklklktgqkivhd 80 
                 + d++e+k++ +++ ++l + +q++  d+++ +p +r+++ke +++er++e+++   ++ + +k+ + 
  EFC36662.1 614 LSDQNEMKQTIKNKQDKLDEMKQHSDFDRYMTDPILRQQFKEfCTKERAEENVIFLEQVMEYKKLSRT 681
                 679*************************************5514555555555544444444444443 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.74   1.5e+03      82     107 ..      33      59 ..       5      91 .. 0.66
   2 ?    9.2   0.2   0.00066       1.3      81     110 ..     372     419 ..     329     443 .. 0.64

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.74
       Shisa  82 iyvpvli.vktifivfvivgvvvivcc 107
                 ++  + + vkt f+++++   + ++c+
  EFC36662.1  33 FGRNFSLrVKTTFVLIIMFLGLMALCL 59 
                 344444327888998888877777776 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00066
       Shisa  81 d..................iyvpvlivktifivfvivgvvvivcccgc 110
                 d                   ++++l+v +++ ++++v +++ivc +  
  EFC36662.1 372 DgeksliirsdiprktfqiGMASFLVVWSVMTFMIVVMSIAIVCFVEM 419
                 13344556666777777754578*********************9764 PP

>> DUF805  Protein of unknown function (DUF805)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.2       1.7   3.4e+03      13      32 ..      45      64 ..      36      86 .. 0.52
   2 ?   13.3   0.8   4.1e-05     0.081      10      66 ..     385     438 ..     380     455 .. 0.66
   3 ?   -2.8   0.0       4.2   8.4e+03      37      67 ..     588     618 ..     556     621 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.7
      DUF805 13 fwwfvlfllllvivlallaa 32
                f ++++fl l+ ++l +l a
  EFC36662.1 45 FVLIIMFLGLMALCLGILLA 64
                33333333333333333222 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 4.1e-05
      DUF805  10 Rsefw.wfvlfllllvivlallaavlaaaavasalsvvlallllvpslavtvRRlHDt 66 
                 R+ f   ++ fl++++++ +++      + +a +  v +++l  v+sl+ tv+R+HDt
  EFC36662.1 385 RKTFQiGMASFLVVWSVMTFMI----VVMSIAIVCFVEMIVLRRVISLSSTVQRVHDT 438
                 6666422222233333332222....224566677777778888888**********8 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 4.2
      DUF805  37 aavasalsvvlallllvpslavtvRRlHDtg 67 
                  + a+ ++v+++ ++ v ++++++R l D++
  EFC36662.1 588 HVTAKRIKVIMGKFTRVDAYMIVARNLSDQN 618
                 3455667777777888888888888888887 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       4.7   9.4e+03      10      39 ..      45      74 ..      44      99 .. 0.54
   2 ?   10.6   0.7   0.00026      0.53       5      76 ..     408     483 ..     403     489 .. 0.72
   3 ?    1.8   0.3      0.15     3e+02      50      75 ..     611     636 ..     587     639 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4.7
      DUF948 10 FvvLviflivvllklkktldeaaatieele 39
                Fv++++fl  + l l+ +l ++    +++e
  EFC36662.1 45 FVLIIMFLGLMALCLGILLAAFFVVFQNVE 74
                555666666555555544444444444443 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00026
      DUF948   5 IaAiAFvvLvifl.ivvllklkktldeaaatieele.......kqvdpilkevedllakvnelledvneklekvdpltea 76 
                 ++ iA+v  v ++  + +++l++t++++ +t++          +++++++k+++++l +++     v+++lek +++++ 
  EFC36662.1 408 VMSIAIVCFVEMIvLRRVISLSSTVQRVHDTVNYAIrapklgnDELGQLSKDLNTMLGEIEH----VQNQLEKDNTVMQD 483
                 45556655553330345566788888888888866667778889999999999999999999....88899998888875 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.15
      DUF948  50 edllakvnelledvneklekvdplte 75 
                 ++ l+  ne+ + +++k +k+d++ +
  EFC36662.1 611 ARNLSDQNEMKQTIKNKQDKLDEMKQ 636
                 55678899999999999999999866 PP

>> Herpes_UL73  UL73 viral envelope glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.4      0.26   5.2e+02      25      67 ..      28      71 ..       8      75 .. 0.70
   2 ?    8.5   3.3     0.001         2      32      60 ..     386     414 ..     384     420 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.26
  Herpes_UL73 25 YsvsCsadtyslsls.SFssiwallnvlvvivalliylrylCfk 67
                  +  C    +sl+++ +F  i ++l+++++   +l+   ++ f+
   EFC36662.1 28 IKTCCFGRNFSLRVKtTFVLIIMFLGLMALCLGILLAAFFVVFQ 71
                 46678899999999625888999999998887777766666665 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.001
  Herpes_UL73  32 dtyslslsSFssiwallnvlvvivalliy 60 
                  +t+++ + SF  +w +++ ++v+++++i+
   EFC36662.1 386 KTFQIGMASFLVVWSVMTFMIVVMSIAIV 414
                  5899********************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (784 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1798  (0.100284); expected 358.6 (0.02)
Passed bias filter:                      579  (0.032294); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.49
# Mc/sec: 4800.80
//
Query:       EFC36663.1  [L=436]
Description: cinnamyl-alcohol dehydrogenase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-15   57.5   0.0    2.3e-15   56.7   0.0    1.4  1  Epimerase        NAD dependent epimerase/dehydratase family
    1.2e-14   54.1   0.0      2e-14   53.3   0.0    1.3  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
    1.4e-12   47.3   0.0    1.9e-12   46.9   0.0    1.2  1  NAD_binding_4    Male sterility protein
    5.1e-08   32.7   0.8    2.3e-07   30.6   0.1    2.3  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    5.5e-06   26.4   0.1     0.0058   16.5   0.0    2.3  2  NAD_binding_10   NAD(P)H-binding
    0.00056   19.5   0.0     0.0013   18.4   0.0    1.6  1  NmrA             NmrA-like family
  ------ inclusion threshold ------
      0.043   13.3   0.1        0.7    9.3   0.1    2.3  2  adh_short        short chain dehydrogenase
      0.052   13.0   0.0       0.12   11.9   0.0    1.6  1  T4BSS_DotI_IcmL  Type-IV b secretion system, inner-membrane c


Domain annotation for each model (and alignments):
>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.7   0.0     1e-18   2.3e-15       1     231 [.      47     315 ..      47     329 .. 0.80

  Alignments for each domain:
  == domain 1  score: 56.7 bits;  conditional E-value: 1e-18
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC..........................EEEE--TT-HHHHHHHHHHHT-SEEEE--S CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl..........................elveldltdrsalerlfkeeqpdavihlAa 73 
                 ++VtGatGfi ++lv +ll+kgy v++  r  +++++++++++                             e+dl+++ ++e+++k  ++  v h A 
  EFC36663.1  47 VCVTGATGFIATHLVYQLLAKGYIVHATVRSLESGRRELIQNIlqfdqknskekgtgllvsrelmeknlVCFEADLLKSGSFEKVIK--GCRFVHHTAS 143
                 69*************************************9999************************99999***************..********88 PP

                 ---HHHHHHSHHHHHHHHTHHHHHHHHHHH.......HHTCT......EEEEEEE.GGGGTSCSSSS....BSTCSTTS----SSHHHHHHHHHHHHHH CS
   Epimerase  74 vggvaassedpadfieknlqgtlnlleaar.......kagvk......rllflsS.sevYGkdaeqp....keettltgplkpnspYaaaKlageklve 154
                    v++  + + d+++  l+gtln+l+++                   r++  sS +++   +   p    +e + + ++   n+pY ++K+ +ek ++
  EFC36663.1 144 PFKVDV-KDPQRDLVDPALKGTLNVLQECVklrksqsS---TdparlqRIMLTSSiASIVETSV--PgkvyDETDWNLDSSVNNNPYLYSKVVAEKAAW 236
                 777777.44557899***************55555441...04444548888888544444333..4445455555444559**************999 PP

                 HHHHHHT.......-EEEEEEESEEESTTS-TTSTTSHHHHHHHHHHT...TSSSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT CS
   Epimerase 155 ayaaqyg.......lnaiilrlfnlyGprngegevsrvipalirkile...gkqevtllgdgtalRdflyveDvaeaillvlehvda 231
                  + ++ +       l+ ++l +  ++Gp      + ++i++  ++i +   g+  + ++  ++    f++v+Dv +a++ ++e+  +
  EFC36663.1 237 TLMQDAQakngddfLELVTLCPAVVIGPP----INPKLISQSHESIMLmarGE--FPVILPLD--FAFVDVRDVSKAHINAMEKNMD 315
                 99888877889*****************9....44444444444443322165..44443444..68****************9444 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.3   0.0     9e-18     2e-14       2     268 ..      49     349 ..      48     359 .. 0.75

  Alignments for each domain:
  == domain 1  score: 53.3 bits;  conditional E-value: 9e-18
   3Beta_HSD   2 vtGgaGFlGralvkeLvrlee..lkevrvlD..........lrespellee.lskvnvkk........viegDvtdkdkleealegvdvvihlaslvdv 79 
                 vtG++GF+  +lv +L+  +     +vr+l           l+++++ ++e  + + v          + e+D+++  + e++++g   v h+as  +v
  EFC36663.1  49 VTGATGFIATHLVYQLLAKGYivHATVRSLEsgrreliqniLQFDQKNSKEkGTGLLVSRelmeknlvCFEADLLKSGSFEKVIKGCRFVHHTASPFKV 147
                 9******************9976789*****99999999984444333222022222221344455789****************************** PP

   3Beta_HSD  80 agkltedeimkvnvkGTrnvleacvk..........agvrvlvYtSsaevvgpnslgeeilngdEeleyeslhqdaypesKalaEklvl.kaNgrtlkn 167
                   k+ +  + +  +kGT nvl+ cvk          a +++++ tSs+  + + s   ++ +  +     s+ +++y +sK +aEk+      + + kn
  EFC36663.1 148 DVKDPQRDLVDPALKGTLNVLQECVKlrksqsstdpARLQRIMLTSSIASIVETSVPGKVYDETDWNLDSSVNNNPYLYSKVVAEKAAWtLMQDAQAKN 246
                 **999999****************98444433333346899************9999999955555555566999**********986414677799** PP

   3Beta_HSD 168 gg.rlyTcaLRpagiyGeg.dkl.lvpllkqlaklglalfkigdeevl....sdrvYvgNvawahilAaralqdpkk.kssvagqayfisddsPvesyd 258
                 g   l  + L pa++ G+  +++ ++++ + +      l+  g+  v+    + +v v  v++ahi A+ +  d+k+     + q + +s+   +  ++
  EFC36663.1 247 GDdFLELVTLCPAVVIGPPiNPKlISQSHESI-----MLMARGEFPVIlpldFAFVDVRDVSKAHINAMEKNMDDKTyFAPSKKQRFVVSNGVTTS-MK 339
                 **6677899********851333023333333.....4444444444422225788899*********9766666552666677788888887766.99 PP

   3Beta_HSD 259 dfnltllkel 268
                 d++ ++ +++
  EFC36663.1 340 DLVNHMREAF 349
                 9999987765 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.9   0.0   8.3e-16   1.9e-12       1     212 [.      49     267 ..      49     305 .. 0.74

  Alignments for each domain:
  == domain 1  score: 46.9 bits;  conditional E-value: 8.3e-16
                    EE-TTSHHHHHHHHHHHHHS-.TEEEEEE-SSSHHHHHHHHHHHT-SS-HHHHHHH.........HHTTTEEEEE--TTSGGGG--HHHHHHHHHH CS
  NAD_binding_4   1 lTGaTGFLGkvLlekLLrttpevkiyllvRaksgesaeeRleeelekkelfsallk.........elaerikvveGDlseprlGLseedlqelaee 87 
                    +TGaTGF++++L+ +LL +     +++ vR+   es+++ l +++ +++ ++   k          +++++++ e+Dl      L++ +++++++ 
     EFC36663.1  49 VTGATGFIATHLVYQLLAKGY--IVHATVRSL--ESGRRELIQNILQFDQKNSKEKgtgllvsreLMEKNLVCFEADL------LKSGSFEKVIKG 134
                    7****************9987..799999987..56899999999999999999779999999988899999999999......5667******** PP

                    --EEEE--S..S-S.STTSSEEHHHHHHHHHHHHHHHTSSS--.-EEEEEE..GGGTTS-TTT--SSS-H......HHH--EEEETTTCCC.HHHH CS
  NAD_binding_4  88 vdviihsaA..tvnfdepykellrvNveGtrevlelakklkklkvllhvST..ayvngeregeveekvyeegekeekldederaklkglpn.tYeq 178
                    +  + h a   +v++++p ++l+++ ++Gt +vl+ + kl+k     + ST  a +++   +     ++e+    +  de++ + + +++n  Y +
     EFC36663.1 135 CRFVHHTASpfKVDVKDPQRDLVDPALKGTLNVLQECVKLRKS----QSSTdpARLQRIMLTSSIASIVETSVPGKVYDETDWNLDSSVNNnPYLY 226
                    ********9445777889********************99988....788866666666666665666666666666666666666666655**** PP

                    HHHHHHHHHHHHHHHH---.......EEEEEE-EEE--SSS CS
  NAD_binding_4 179 sKalaEklvrearrrsglp.......vvivRpsiitgeskt 212
                    sK++aEk   + ++  + +       +v + p +++g + +
     EFC36663.1 227 SKVVAEKAAWTLMQDAQAKngddfleLVTLCPAVVIGPPIN 267
                    ******97666553322222222222566666666665555 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   0.1     1e-10   2.3e-07       2     118 ..      49     176 ..      48     240 .. 0.72
   2 ?   -2.5   0.0       1.2   2.6e+03     240     260 ..     323     343 ..     296     348 .. 0.59

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 1e-10
                    EETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCC..............EEEEE--TT-HHHHHHHHHHHT-SEEEE-- CS
  GDP_Man_Dehyd   2 iTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleen..............lklhkgDltDssslerllaevqpdevynLA 83 
                    +TG +Gfi  +l+ +Ll+kgy vh +vr  +s + + i+++ + ++++ +e+              l  +++Dl  s s e++++ ++   v + A
     EFC36663.1  49 VTGATGFIATHLVYQLLAKGYIVHATVRSLESGRRELIQNILQFDQKNSKEKgtgllvsrelmeknLVCFEADLLKSGSFEKVIKGCR--FVHHTA 142
                    9*******************************99999998876544433322222222222222227788888888888888888885..578888 PP

                    S---HHHHTTSHHHHHHHHTHHHHHHHHHHHHCT. CS
  GDP_Man_Dehyd  84 AqshVdvsfekPeytaevnvlGtlrLLeairalgl 118
                        Vdv+  +    ++  + Gtl++L+ + +l  
     EFC36663.1 143 SPFKVDVKDPQ-RDLVDPALKGTLNVLQECVKLRK 176
                    88888875443.67888899999999987766643 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.2
                    SS---EEE-TT-EEECHHCHH CS
  GDP_Man_Dehyd 240 dkpedyviatgethsvrefve 260
                     k++ +v+++g t+s++++v+
     EFC36663.1 323 SKKQRFVVSNGVTTSMKDLVN 343
                    344566777777777766665 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   2.6e-06    0.0058       1      31 [.      51      80 ..      51      99 .. 0.88
   2 !    7.6   0.0    0.0014       3.2      38     144 ..     112     242 ..     106     255 .. 0.71

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 2.6e-06
                    TTTSHHHHHHHHHHHHC-T-EEEEEETTHHH CS
  NAD_binding_10  1 GAtGkvGrllvkellargghevtalvRnpek 31
                    GAtG ++ +lv +lla+g + v+a vR+ e+
      EFC36663.1 51 GATGFIATHLVYQLLAKG-YIVHATVRSLES 80
                    9****************5.********9765 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0014
                     TTTCEEEE--TT-CCHHHHHHTT-SEEEES---TCC...HHHH.....................HHHHHHHHHHCT--EEEEEEETTT..TSGCG CS
  NAD_binding_10  38 eeglevvegdvtdvedlaealkgadaVvsalggggk...deeg.....................aknivdaakeagvkRfvlvsaigv..gdevp 106
                     e++l  +e+d++++ + ++++kg+  V  ++++ +    d                         ++     + a  +R+ l s+i +  + +vp
      EFC36663.1 112 EKNLVCFEADLLKSGSFEKVIKGCRFVHHTASPFKVdvkD--PqrdlvdpalkgtlnvlqecvkLRKSQSSTDPARLQRIMLTSSIASivETSVP 204
                     4789999************************887775542..13356677778877777776666666777888999999999998752266777 PP

                     CHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEEEEEEE- CS
  NAD_binding_10 107 gefgewnkellkaylaakraaeellrasgldwTivrpg 144
                     g++ + ++ +l + +    +    + a +  wT ++ +
      EFC36663.1 205 GKVYDETDWNLDSSVNNNPYLYSKVVAEKAAWTLMQDA 242
                     77655444456666666666666666666666666555 PP

>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   5.7e-07    0.0013       1      75 [.      47     145 ..      47     164 .. 0.66

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 5.7e-07
                 EEESSTTSHHHHHHHHHHHHHT-EEEEEES-S........................-SHHHHHHHHSTTEEEES-TT-HHHHHHHHTT-SEEEE---GG CS
        NmrA   1 IlviGaTGrqGksvvrallkaghkvralvRdt........................kselakslkeaGvelvkgdlddkeslvealkgvdvvfsvtgfy 75 
                 + v+GaTG ++ ++v  ll++g+ v a vR +                           ++++l e+  +  ++dl    s ++++kg   v  + + +
  EFC36663.1  47 VCVTGATGFIATHLVYQLLAKGYIVHATVRSLesgrreliqnilqfdqknskekgtGLLVSRELMEKNLVCFEADLLKSGSFEKVIKGCRFVHHTASPF 145
                 679*****************************7786666666666665555544322233445555555555555556666666666666666655555 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.1   0.00031       0.7       2      43 ..      46      88 ..      45      98 .. 0.79
   2 ?    1.4   0.0     0.081   1.8e+02      10      67 ..     100     156 ..      97     202 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00031
                EEEEESTTSHHHHHHHHHHHHTT-EEEEEESC.HHHHHHHHHH CS
   adh_short  2 vvlvtGassGIGraiakelakeGakvvvvdrs.eekleevake 43
                +v+vtGa++ I   ++++l+++G+ v ++ rs e+  +e++++
  EFC36663.1 46 HVCVTGATGFIATHLVYQLLAKGYIVHATVRSlESGRRELIQN 88
                69**************************555504455555555 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.081
                 SHHHHHHHHHHHHTT-EEEEEES.CHHHHHHHHHHHHHTTSEEEEEE-TTTSHHHHHHH CS
   adh_short  10 sGIGraiakelakeGakvvvvdr.seekleevakelkeegakalaiqvDvtdreeveal 67 
                 +G G+ +++el++++  ++ +d  ++   e+v+k ++    +a +++vDv+d ++  +l
  EFC36663.1 100 KGTGLLVSRELMEKNLVCFEADLlKSGSFEKVIKGCRFVHHTASPFKVDVKDPQR--DL 156
                 7889999999999998888866514556889999999889999999999997753..44 PP

>> T4BSS_DotI_IcmL  Type-IV b secretion system, inner-membrane complex component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   5.3e-05      0.12      55      88 ..     399     432 ..     376     434 .. 0.93

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.3e-05
  T4BSS_DotI_IcmL  55 WaakavlkaytldfvnYrsqLqkaseefteegwe 88 
                      + + ++++ ++ldf n+++  +++ +  +e+g+ 
       EFC36663.1 399 FNNSKIRNTFNLDFMNWKDSVTDSVKFLDENGFI 432
                      56789***************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (436 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2660.27
//
Query:       EFC36664.1  [L=330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      2e-27   96.6   3.2      2e-27   96.5   0.1    2.0  2  UvrD-helicase  UvrD/REP helicase N-terminal domain
    1.5e-16   61.1   0.0    2.8e-16   60.2   0.0    1.4  1  AAA_19         AAA domain
    1.1e-09   38.2   2.4    2.3e-09   37.2   2.4    1.6  1  zf-GRF         GRF zinc finger
    0.00022   21.0   0.0    0.00031   20.5   0.0    1.2  1  AAA_30         AAA domain
     0.0034   17.2   5.0     0.0058   16.4   0.0    2.2  2  AAA_11         AAA domain
     0.0081   15.9   0.0      0.021   14.6   0.0    1.6  1  DUF3440        Domain of unknown function (DUF3440)
  ------ inclusion threshold ------
        9.9    4.6  14.5         13    4.2  14.5    1.1  1  Macoilin       Macoilin family


Domain annotation for each model (and alignments):
>> UvrD-helicase  UvrD/REP helicase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.8      0.14   3.7e+02     147     173 ..      68      93 ..      13     175 .. 0.49
   2 !   96.5   0.1   7.9e-31     2e-27       1     125 [.     206     327 ..     206     330 .] 0.91

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.14
                    TTHHHHHHHHHHHHHHCCCCCHHHHCC CS
  UvrD-helicase 147 lnldkkkleklikelsksrnikkeels 173
                     n + ++ e ++ + ++++ i+  +++
     EFC36664.1  68 SNSKLQHSE-QAFDDTLNKTIQLMNRV 93 
                    111111111.11222222222222222 PP

  == domain 2  score: 96.5 bits;  conditional E-value: 7.9e-31
                    SSHHHHHHHHS.-SSEEEEEE-TTSSHHHHHHHHHHHHHHTSSSTGGGEEEEESSHHHHHHHHHHHHHHHHHCCHHCTT-HHHHHHHHHCTTSEEE CS
  UvrD-helicase   1 lnpeqreaias.lggpilveAsAGsGKTfvlaerilrlikeeeiepdrilvvTFTnkAaeElkeRieealkkaeqessdderlrlalqnlseanis 95 
                    ln +q ea+    +  + v++++GsGKT+++++ri++l   ++iep++++++TFTnkAa+E+k+R+ +++k   +++          +  +  +i+
     EFC36664.1 206 LNSKQLEAVCAsEHDCVCVYSGPGSGKTKTITNRIAYLCIVKGIEPRNVFAMTFTNKAAQEMKTRLVHLVKLYDFQK--------RINAKDFSHIG 293
                    688999**9995566678**************************************************999997654........455667789** PP

                    EHHHHHHHHHHHHHGGTT....SHTTTEEECHHH CS
  UvrD-helicase  96 TlHsfcqkilkkeanrig....ldpnfrildeed 125
                    T+H++c +il++e++++     ld++f i+d+e+
     EFC36664.1 294 TFHAVCANILRNEMHHLTrivgLDQKFMIFDSEE 327
                    ****************999999*********998 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.2   0.0   1.1e-19   2.8e-16       1      77 [.     210     300 ..     210     328 .. 0.85

  Alignments for each domain:
  == domain 1  score: 60.2 bits;  conditional E-value: 1.1e-19
      AAA_19   1 qreavealkekvllvtaGpGtGKTrvlkhivallvelggvkpeeillvaftgrAakelrerlaalgae...............atTiHrlal 77 
                 q eav a+++++++v  GpG+GKT++++ ++a+l  ++g++p+++ +++ft++Aa+e+++rl  l  +               + T+H++  
  EFC36664.1 210 QLEAVCASEHDCVCVYSGPGSGKTKTITNRIAYLCIVKGIEPRNVFAMTFTNKAAQEMKTRLVHLV-KlydfqkrinakdfshIGTFHAVCA 300
                 789999********************************************************5544.4599999999999999999998843 PP

>> zf-GRF  GRF zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.2   2.4     9e-13   2.3e-09       2      44 ..       7      50 ..       6      51 .. 0.92

  Alignments for each domain:
  == domain 1  score: 37.2 bits;  conditional E-value: 9e-13
      zf-GRF  2 lCkcgrlavlltvrktgpNkGRkFYkCpkgke..kqCgFFkWade 44
                 C cg +a++ t + +g+N+GRk+  C+k     + C FFkW d+
  EFC36664.1  7 KCHCGLIAKQGTTS-KGENQGRKYTSCSKSMTdkSRCKFFKWLDS 50
                5************9.9************98777799******997 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   1.2e-07   0.00031       2      65 ..     206     270 ..     205     307 .. 0.82

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.2e-07
      AAA_30   2 lnaeQaaavealltsgdrvavltGpAGtGKttalkal.reaweaag...grviglAptgkaAkvLaee 65 
                 ln++Q +av   ++s++ ++++  ++G+GKt +++   + +   +g   ++v++++ t+kaA+++++ 
  EFC36664.1 206 LNSKQLEAV---CASEHDCVCVYSGPGSGKTKTITNRiAYLCIVKGiepRNVFAMTFTNKAAQEMKTR 270
                 777888777...6777779999999******988765266655567888****************975 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   2.8      0.13   3.2e+02     140     206 ..      42     106 ..       5     155 .. 0.64
   2 !   16.4   0.0   2.3e-06    0.0058       2      80 ..     206     279 ..     205     314 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.13
      AAA_11 140 lrafeeeeekeklkkskekskskleqerrklkkerkelskeleeaeesleeevldeaeivltTlsga 206
                  + f++ +++e+++++   s+s+  ++++kl+ + + ++++l+++ + + +  +  +++  +T  ++
  EFC36664.1  42 CKFFKWLDSSEQTATTNISSSSSSFKSNSKLQHSEQAFDDTLNKTIQLM-N-RVLPSSLLSSTSGSS 106
                 3345555555666666666666666666666666666666666666655.2.222333444444444 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 2.3e-06
      AAA_11   2 lndsqreaiksalseseitliqGPPGtgKTktivellsqllsrrkseeeksakpriLvCapSNaAvDellerllr..glld 80 
                 ln++q+ea+  + se++ +++   PG+gKTkti+  +++l        ++ +++++ + + +N+A  e+  rl+   +l+d
  EFC36664.1 206 LNSKQLEAV--CASEHDCVCVYSGPGSGKTKTITNRIAYL-----CIVKGIEPRNVFAMTFTNKAAQEMKTRLVHlvKLYD 279
                 788888887..56677778888888***************.....456789999999999999999999999988554444 PP

>> DUF3440  Domain of unknown function (DUF3440)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0     8e-06     0.021     121     172 ..     259     315 ..     245     320 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 8e-06
     DUF3440 121 veeksnyktek...kvvrlkeylddidikefkeiPtykrmcicilknD..hlCkymg 172
                  ++k++ +++    + v+l +++  i+ k+f +i t++ +c  il+n+  hl + +g
  EFC36664.1 259 FTNKAAQEMKTrlvHLVKLYDFQKRINAKDFSHIGTFHAVCANILRNEmhHLTRIVG 315
                 444444444441247778888888999********************7335566665 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2  14.5     0.005        13     235     393 ..      38     208 ..      10     250 .. 0.46

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.005
    Macoilin 235 sknnhslnkk....dsslklpeleyrekkksakssrsdskkkhehnesvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssn. 328
                 +k   +        dss+++++ + +++++s ks+   sk +h+ +++ d+ l+++  + n++ +  l +s+s +s+s+   ++s +++++s+ ss + 
  EFC36664.1  38 DKSRCK---FfkwlDSSEQTATTNISSSSSSFKSN---SKLQHS-EQAFDDTLNKTIQLMNRVLPSSLLSSTSGSSSSSS-NNKSPSNNTNSQCSSLTl 128
                 222222...13335777777777777776666655...323333.34455555444444555555554444333332222.222222222222222211 PP

    Macoilin 329 ....knskkasagsagssnssskkhses...sksvtsssssknskkqklpaGkssaalkdaaenslpnnql.........s 393
                     +++++ + ++  s  sss+  ++    ++s   ss s++  k++lp   +++++  +   slpn+ l         s
  EFC36664.1 129 sqlcSSMEDLNIDKDLSKPSSSQAIDRDfilNDSLFPSS-SSEASKNSLPLIGNNQHKGGTSSSSLPNSLLeecmqkelnS 208
                 223333333333333333344433333211133433333.33344555554333333444445555555443333222223 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1553  (0.0866194); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1985.06
//
Query:       EFC36665.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   9.6e-105  350.3   1.5   1.1e-104  350.1   1.5    1.0  1  DUF4419   Domain of unknown function (DUF4419)


Domain annotation for each model (and alignments):
>> DUF4419  Domain of unknown function (DUF4419)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  350.1   1.5  6.3e-109  1.1e-104       1     302 []      23     325 ..      23     325 .. 0.95

  Alignments for each domain:
  == domain 1  score: 350.1 bits;  conditional E-value: 6.3e-109
     DUF4419   1 ngfveavleAyaehlhLvlrPDdvWlaIltqlsfyvnanaeelrslfvahegkkelevkaeekle..dweelakelteeiqknvkdpslrdwilpdFsT 97 
                 n+fv + ++Ay++h+h v++PDdvW+aI++q+s+yvn+++e+lrs+fv+++gkkel+vk  ++l+  ++e+l  ++t ei+kn+kdps+r+w++pdF+T
  EFC36665.1  23 NSFVMSGVQAYSKHHHWVIKPDDVWIAICSQFSNYVNERSEKLRSKFVDFDGKKELVVKGIGTLYtaNYEDLSIRMTSEIAKNIKDPSVREWVMPDFTT 121
                 8*********************************************************999999899******************************** PP

     DUF4419  98 ttetdkvvaavllmatlkkyfeykvsllCGiPsvtLlGekeDWekllerlekLkefg...eelkewaklLrpildrfvesfdepdseenkeFWnkivke 193
                 tt++d++v av+lma++kkyf+yk++l C +PsvtLlG+ eDW k++er+++L ef+   e +k+w+++L p+ld+fves++  +++ +ke+Wn++++ 
  EFC36665.1 122 TTQSDRMVGAVVLMAAMKKYFDYKFELECNLPSVTLLGQVEDWIKIRERANRLLEFDteeECMKKWSQYLFPVLDKFVESIK--GNP-DKEWWNRVANF 217
                 ********************************************************555599********************..656.799******** PP

     DUF4419 194 eseegsgeselsGWitaFcvydkdgkvleeekkeeeeeeseeee...alvldgveypeidtddipsglasvpvkldedngkeyelelvaGsvGvkvsse 289
                  ++ gsg+s +sGWit+Fcv++++gk+l+++k+e e   ++e++   ++++ + e+p id ++ip+g++svp+++d dng+ y++e++aG++  +v ++
  EFC36665.1 218 LGG-GSGPSFISGWITTFCVFSETGKWLGDQKTEGEVWYEDEDDnepKEKVREREWPVIDDEEIPRGYVSVPITVD-DNGTVYKTEMFAGHIVASVLNQ 314
                 *99.9**************************999988777666667788889999********************9.999****************998 PP

     DUF4419 290 eedtlqpvsgWal 302
                 +   +qp ++Wal
  EFC36665.1 315 N--SIQPRVDWAL 325
                 5..9*******96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       542  (0.0302304); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2366.90
//
Query:       EFC36666.1  [L=597]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.2e-06   26.2   0.6        5.9    7.1   0.0    5.6  5  NHL           NHL repeat
    9.1e-05   22.9   0.3    0.00024   21.5   0.3    1.8  1  GPS           GPCR proteolysis site, GPS, motif
     0.0018   18.6   9.5     0.0018   18.6   9.5    2.2  2  EGF_2         EGF-like domain
  ------ inclusion threshold ------
        1.3    9.4   9.4       0.24   11.8   3.7    2.8  3  EGF           EGF-like domain
          5    7.3  12.9         17    5.6  12.9    1.9  1  EGF_Tenascin  Tenascin EGF domain


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.3   0.1    0.0061        22       1      25 [.     103     127 ..     103     128 .. 0.87
   2 ?    1.0   0.0      0.14   5.2e+02      16      27 ..     180     191 ..     178     192 .. 0.92
   3 ?   -1.3   0.0      0.75   2.7e+03       2      22 ..     206     228 ..     205     231 .. 0.80
   4 !    5.2   0.0    0.0068        24       1      22 [.     265     288 ..     265     292 .. 0.88
   5 !    7.1   0.0    0.0016       5.9       7      27 ..     329     349 ..     323     350 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0061
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 +n+P G+ +++n+diy+a ++ +r+
  EFC36666.1 103 LNRPYGLFISNNNDIYIAGNYANRI 127
                 688999999*********8888887 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.14
                 EEEECCCTEEEE CS
         NHL  16 yVaDsenhrvqv 27 
                 ++aD++ +r++v
  EFC36666.1 180 IIADTYGSRIRV 191
                 79********98 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.75
                 SSEEEEEEE.TTTEEEEEE.CCC CS
         NHL   2 nyPhGvavd.snGdiyVaD.sen 22 
                 +yP G+  d +++++++ + s n
  EFC36666.1 206 SYPFGIESDsDSNELLIGCaSPN 228
                 677788889999***99987766 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0068
                 BSSEEEEEEE.TTTEEEEEE.CCC CS
         NHL   1 fnyPhGvavd.snGdiyVaD.sen 22 
                 fn+ +Gva++  nG iy+a+ ++n
  EFC36666.1 265 FNNVNGVAISkLNGAIYIAEpNGN 288
                 88999*****99*******97666 PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.0016
                 EEEETTTEEEEEECCCTEEEE CS
         NHL   7 vavdsnGdiyVaDsenhrvqv 27 
                 ++ +++G+i+ +D+ n+r+++
  EFC36666.1 329 IVTTKSGEIFFTDTSNNRIRK 349
                 66779**************97 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.3   6.8e-08   0.00024       2      45 .]     541     579 ..     540     579 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 6.8e-08
         GPS   2 sCvfWdeeneetgsWsteGCeltesdnknetvCsCnHLtsFAvL 45 
                 +C + d   e  ++W  +G e t+  ++  ++C  +HLtsF+v+
  EFC36666.1 541 TCMYFD---ELVNEWKLDGVE-TKI-EEWTVTCLTSHLTSFSVI 579
                 8****6...5679********.665.7888************96 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   9.5     5e-07    0.0018       5      32 .]     379     405 ..     376     405 .. 0.89
   2 ?   -1.9   0.2       1.3   4.5e+03      10      15 ..     414     419 ..     409     422 .. 0.59

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 5e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ Cg +G+C +    C+Cdsgy+G +C
  EFC36666.1 379 SNVCGSNGKCQAVD-SCVCDSGYYGLDC 405
                 689*******9777.6***********9 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.3
       EGF_2  10 ghGtCv 15 
                  +G Cv
  EFC36666.1 414 TNGECV 419
                 356665 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.73   2.6e+03      24      29 ..     354     359 ..     353     361 .. 0.83
   2 ?   11.8   3.7   6.6e-05      0.24       3      30 ..     379     402 ..     377     404 .. 0.87
   3 ?   -3.0   0.1       2.7   9.6e+03       9      14 ..     415     420 ..     413     422 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.73
                 ECTTEE CS
         EGF  24 CpeGyt 29 
                 Cp+Gy 
  EFC36666.1 354 CPTGYV 359
                 ****96 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 6.6e-05
                 STTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytG 30 
                 +n C  +G+C  +     +C C++Gy G
  EFC36666.1 379 SNVCGSNGKCQAVD----SCVCDSGYYG 402
                 566*******9999....********99 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 2.7
                 T-EEEE CS
         EGF   9 gGtCvd 14 
                 +G+Cv+
  EFC36666.1 415 NGECVN 420
                 789*98 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6  12.9    0.0047        17       6      29 .]     382     406 ..     381     406 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0047
  EGF_Tenascin   6 CssRGvC..vDGqCiCDsEYsGDDCs 29 
                   C s G C  vD  C+CDs Y G DCs
    EFC36666.1 382 CGSNGKCqaVD-SCVCDSGYYGLDCS 406
                   99999996566.6************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (597 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       902  (0.0503096); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.62u 0.27s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 3926.94
//
Query:       EFC36667.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.5e-09   35.9   0.2    1.4e-08   34.6   0.1    1.7  2  RWP-RK        RWP-RK domain
  ------ inclusion threshold ------
      0.037   13.4   0.0      0.066   12.6   0.0    1.3  1  HTH_Tnp_ISL3  Helix-turn-helix domain of transposase family I
      0.046   13.5   0.0       0.08   12.7   0.0    1.4  1  HTH_8         Bacterial regulatory protein, Fis family
      0.099   12.2   0.0       0.21   11.2   0.0    1.5  1  HTH_24        Winged helix-turn-helix DNA-binding


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.6   0.1   3.1e-12   1.4e-08       2      43 ..      98     143 ..      97     145 .. 0.92
   2 ?   -3.8   0.0         3   1.3e+04      12      25 ..     224     237 ..     223     239 .. 0.72

  Alignments for each domain:
  == domain 1  score: 34.6 bits;  conditional E-value: 3.1e-12
      RWP-RK   2 ltleelqqyFslplkeAAksLgvskttLKricR....elgIsRWPy 43 
                 +++++++++ +l+ k+AAk+L+vs +tLKr+      elg  +WPy
  EFC36667.1  98 IDVHAMRSCLHLNQKDAAKKLNVSLSTLKRRFYemrhELGCDKWPY 143
                 78999*************************987666799******8 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 3
      RWP-RK  12 slplkeAAksLgvs 25 
                 +l+++  +k+L+  
  EFC36667.1 224 HLTIERGSKKLKTA 237
                 67888888888765 PP

>> HTH_Tnp_ISL3  Helix-turn-helix domain of transposase family ISL3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.5e-05     0.066      20      48 ..     102     129 ..      97     131 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.5e-05
  HTH_Tnp_ISL3  20 ilelllesrsvkavArqlgvSwtTVwril 48 
                   +++++l+  + k++A+ l+vS +T++r++
    EFC36667.1 102 AMRSCLHL-NQKDAAKKLNVSLSTLKRRF 129
                   8999****.******************99 PP

>> HTH_8  Bacterial regulatory protein, Fis family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.8e-05      0.08      20      38 ..     110     128 ..     100     130 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.8e-05
                 -HHHHHHHHTS-HHHHHHH CS
       HTH_8  20 nkskAArlLGisRrtLyrK 38 
                 n+++AA+ L++s +tL r+
  EFC36667.1 110 NQKDAAKKLNVSLSTLKRR 128
                 9***************998 PP

>> HTH_24  Winged helix-turn-helix DNA-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   4.7e-05      0.21      17      37 ..     108     128 ..     108     132 .. 0.94

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4.7e-05
      HTH_24  17 risqreLAerlglSpstvnrr 37 
                 +++q++ A++l++S+st++rr
  EFC36667.1 108 HLNQKDAAKKLNVSLSTLKRR 128
                 589****************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2375  (0.132467); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                        32  (0.00178482); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.93u 0.37s 00:00:01.30 Elapsed: 00:00:00.56
# Mc/sec: 1818.75
//
Query:       EFC36668.1  [L=488]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.6e-57  192.7   3.9    1.6e-56  191.8   3.9    1.5  1  Peptidase_C1    Papain family cysteine protease
    2.2e-41  140.9   0.9    5.4e-41  139.6   0.9    1.7  1  CathepsinC_exc  Cathepsin C exclusion domain
  ------ inclusion threshold ------
      0.011   14.5   0.3      0.011   14.5   0.3    1.7  2  Peptidase_C1_2  Peptidase C1-like family


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  191.8   3.9   2.7e-60   1.6e-56       1     216 [.     256     482 ..     256     484 .. 0.88

  Alignments for each domain:
  == domain 1  score: 191.8 bits;  conditional E-value: 2.7e-60
                   STSCEETTT.TTTG.SG---B-T.SSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS--SS CS
  Peptidase_C1   1 lpesvDwre.kgga.vtpvkdqg.sCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdypYka 93 
                   lp+++ w + +g++ v pv++qg  CGsC+afs+ +++ +r+ + t+ +k    S q++v+Cs   ++gC+GG+m  + +y+++ g+++e++ pYk+
    EFC36668.1 256 LPKEFSWTNvNGMNlVVPVRNQGvFCGSCYAFSSSDMFGSRVRVITNgTKTPVYSPQDIVECSA-YSQGCDGGFMYLVSKYAEDYGLAEESCDPYKG 351
                   699******655568********78*****************9999989999***********8.89****************************** PP

                   SCSSS-CGCGGGSE.....EBEESEEEEEESS..BHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESST...SCET.......SS-EEEEEEEEE CS
  Peptidase_C1  94 keggkCkkkkkkek.....vakikgygkvken..seealkkalakngPvsvaidaseedfqlYksGvyket...ecsk.......telnhavlivGy 173
                    + + Ckk+++ ++     +a + g+        + ++++ +l++ gP+++a+++++ df +Yk+Gvy+++   +  +       +e+nhavl+vG+
    EFC36668.1 352 VD-SVCKKDQCPKRaygtnYAYTGGFY----GatNAKNMMYELYHGGPLAIAFEVYD-DFFNYKGGVYTHStalK--TkiaepgwEETNHAVLLVGW 440
                   **.699999877665332233333333....233689********************.6***********97551..2445578899********** PP

                   EEETTEEEEEEE-SBTTTSTBTTEEEEESSSSTGGGTTSSEEE CS
  Peptidase_C1 174 gvengkkyWivkNsWgtdwgekGYiriargknnecgieseava 216
                   g+eng++yW+vkNsWgt+wg +G+++i+rg++ ec+ eseav+
    EFC36668.1 441 GEENGVPYWLVKNSWGTSWGINGFFKIKRGTD-ECDCESEAVS 482
                   ******************************99.******9986 PP

>> CathepsinC_exc  Cathepsin C exclusion domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.6   0.9   9.1e-45   5.4e-41       1     120 [.      23     147 ..      23     148 .. 0.96

  Alignments for each domain:
  == domain 1  score: 139.6 bits;  conditional E-value: 9.1e-45
  CathepsinC_exc   1 dlpvnClyedivGkWkfevsek...gedksvkCskevpdkakaskkvevelkkpnvvvdekknkgkwtliYdqGfevelnkrkyfaffkykkegs 92 
                     d+pv+Cl++++ G W+f+ +++   ++  + +C  ++p  + ++++++++l +p+vv+de++n+g+wtliYdqGfev++nk+kyfaff+y+++g+
      EFC36668.1  23 DIPVHCLFHQVFGDWTFYRTSTsfsNDVVHNTCALTNPLPNVNVDTIKLRLLAPDVVYDEQGNEGFWTLIYDQGFEVVINKQKYFAFFNYTQQGK 117
                     89****************9999885666899**************************************************************** PP

  CathepsinC_exc  93 kvtsyCnetlvgwvhd..vlgknwaCfkgk 120
                      vts+C++t++gw+hd  + +k+++Cf+g 
      EFC36668.1 118 VVTSNCGQTFTGWYHDagIAVKKFGCFRGI 147
                     ****************88899*******97 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.2      0.29   1.8e+03      15      75 ..     227     292 ..     216     299 .. 0.62
   2 ?   14.5   0.3   1.9e-06     0.011     348     397 ..     420     467 ..     401     471 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.29
                     CTSHHHHHHHHHHTTS-HHHHHB-HHHHHH-----S.EE-SS-....S--B--B.SSTHHHHHHHHH CS
  Peptidase_C1_2  15 kadpknkvianaakksglleallnkkvkkelervFs.tevetd....evtnqkq.sGRCWlFaalnv 75 
                     +++  ++++++ a+ +g +++++++ v++ l + Fs t+v+      +v nq    G C+ F++ ++
      EFC36668.1 227 QKERFQTIFQTQARVNGNKKIITEEDVNA-LPKEFSwTNVNGMnlvvPVRNQGVfCGSCYAFSSSDM 292
                     45555666777777777777776666654.4444551444433566778888643788888887665 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 1.9e-06
                     HHHHHHTTS----EEEEEEEEEE-TTSSEEEEEEE-SBTTTSTBTTEEEE CS
  Peptidase_C1_2 348 kAerldygeslmtHamvltgvdvdddgkvtkwkvEnsWGedsGekGyfvm 397
                     k +  + g  + +Ha++l+g  + ++g v  w v nsWG   G +G+f +
      EFC36668.1 420 KTKIAEPGWEETNHAVLLVGWGE-ENG-VPYWLVKNSWGTSWGINGFFKI 467
                     5555555667899********99.555.667****************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       694  (0.0387082); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 3260.31
//
Query:       EFC36669.1  [L=735]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.2e-33  115.4   0.0    8.5e-33  114.7   0.0    1.3  1  NIT              Nitrate and nitrite sensing
    2.9e-24   85.7   0.0    9.8e-24   84.0   0.0    1.8  2  Guanylate_cyc    Adenylate and Guanylate cyclase catalytic do
  ------ inclusion threshold ------
       0.33   10.1  10.0        0.3   10.2   0.6    2.7  2  Polysacc_synt_3  Polysaccharide biosynthesis protein


Domain annotation for each model (and alignments):
>> NIT  Nitrate and nitrite sensing
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  114.7   0.0   1.4e-36   8.5e-33       1     227 [.     155     399 ..     155     401 .. 0.82

  Alignments for each domain:
  == domain 1  score: 114.7 bits;  conditional E-value: 1.4e-36
         NIT   1 dLvhaLQkERglsagylasgggerkaaelaaqraatDaalaalr...............al.aglarrldallraldqLpalRrqv.dtr.kldakeav 81 
                 d++h+ Q ERg s++y++sgg +++  el + r++tD a++a++               +  ++ +++l+++++ +++Lp +R+++ + + +++ k a+
  EFC36669.1 155 DVTHRTQIERGSSSLYMGSGG-KSFVLELPQYRNDTDNAIKAYQarkvtllqilgddstRIyKNSDDNLKGIDTYIAGLPVWREKIwKLQfNVT-KVAL 251
                 689****************86.567777**************99889888888865554122333666666666667*********77443544.7778 PP

         NIT  82 aaYtdviaaLldladelaqgspdrelarqlralaalsrakEalsqerallaaalaagrfsaalyaaflslvarqqaalaefraaatpaqralydetvt. 179
                 ++Yt+ ++ ++d +  ++ +s+d++ ++  + ++ l  +kE  ++ ra+++++laagr+s+a+y+ fl+ ++++++++  ++  ++++    + + vt 
  EFC36669.1 252 DYYTNWNTLMIDTILMISGQSTDATFTNIQTVYNFLTAMKEFNGLKRAVGSNGLAAGRLSTANYNYFLQIQTQSDLLQHYLDLKSNDQFHNEFINRVTs 350
                 ****************999******************************************************99988888888888866666666652 PP

         NIT 180 gpavkaaetlrdrlastggv..daed.e....eeWfaastaridqlravesrlad 227
                  p + + +t+++       +  + ++ +    ++Wf+++t +i+++r+ve+ l++
  EFC36669.1 351 TPVYSQCKTMETY------IvnNYQSlTlyksTDWFNNMTLVINAMREVEDVLRN 399
                 77*********99......322222242334667*****************9986 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.45   2.7e+03       3      54 ..     143     201 ..     141     212 .. 0.72
   2 !   84.0   0.0   1.6e-27   9.8e-24       9     176 ..     486     653 ..     483     659 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.45
  Guanylate_cyc   3 aesydevtilFadIvgftalssahs.......pievvklLnelyarfdelldekkvykv 54 
                     +s +e ++l ad+   t++   +s       ++  v  L ++ ++ d+ +++++  kv
     EFC36669.1 143 IQSLSELSVLLADVTHRTQIERGSSslymgsgGKSFVLELPQYRNDTDNAIKAYQARKV 201
                    57888899999999988888877776666666777777777777777777777775554 PP

  == domain 2  score: 84.0 bits;  conditional E-value: 1.6e-27
  Guanylate_cyc   9 vtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskeglkvrv 104
                      i+F d++++t +s+  + ++v+k++n++ + +  ++++++ y +k++Gd + +++  p  +  haa +++ aL++++++   +    ++l v++
     EFC36669.1 486 LDIMFVDVRNYTGISESLTSQKVFKFINKYLKVVGPIIRRHNAYIDKYLGDGFAALFLEP-GQSVHAAIAIQNALEVFNETLGPKY---PSLAVGI 577
                    569******************************************************999.99999***********998755544...56***** PP

  Guanylate_cyc 105 GihtGpvvagviG.akkprydvwGntvnlAsrmestgkag..kiqvseetyellk.eeqfeltergevevkGkgkl 176
                    Gi +G+v +g++G  k+++ +++G++vnl +r+es++k++  ki vs++  +    +e+  ++++g+v v Gk++ 
     EFC36669.1 578 GIVRGSVAVGLVGeSKRMDPTIIGDSVNLSARLESLTKQYgaKILVSRNILDTTPhTEDNFFRRIGKVAVVGKKES 653
                    *************888999******************985338999***9999987888889999*******8765 PP

>> Polysacc_synt_3  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.9    0.0017        10     220     265 ..      45      90 ..      41     113 .. 0.88
   2 ?   10.2   0.6   5.1e-05       0.3      52     146 ..     344     439 ..     312     451 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0017
  Polysacc_synt_3 220 laslpvaeitsviakVlfPalSrlqddkkklrelylkvlrlialiv 265
                       +++ +++ t+v ++ ++P  ++ q+d+ + r+++  v+ +++++ 
       EFC36669.1  45 QPTIATTTTTTVTTTTTTPQQAHHQEDELETRKTLSSVVTSTSILN 90 
                      5678899999*****************************9999875 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 5.1e-05
  Polysacc_synt_3  52 tfnlvlgllialvlfllapliasfynqpelvtvl.rvlalvlilsglssvqeallrrelkFkklfkitlvssvvgvivaivlAllglgvwALvi 144
                       +n v+++ ++     +  +i + y++  l++ + ++  ++l+++++  v+  l + +l++ ++   + ++s++g++va   + ++ +  A+v+
       EFC36669.1 344 FINRVTSTPVYSQCKTMETYIVNNYQSLTLYKSTdWFNNMTLVINAMREVEDVLRNTSLDYANQLNNQAIGSLIGFVVATFFVTCLSTTIAIVF 437
                      5677777888888888888888888888888877356789*****************************************************9 PP

  Polysacc_synt_3 145 gt 146
                      ++
       EFC36669.1 438 SK 439
                      75 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (735 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1122  (0.0625802); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.45
# Mc/sec: 4885.31
//
Query:       EFC36670.1  [L=1767]
Description: viral A-type inclusion repeat protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.022   15.4  24.5       0.23   12.1   0.1    6.9  6  SlyX           SlyX
      0.023   14.7   4.1        1.1    9.2   1.0    3.3  2  Serine_rich    Serine rich protein interaction domain
      0.024   14.8   0.1      0.088   13.0   0.1    2.0  1  NAD_binding_2  NAD binding domain of 6-phosphogluconate dehyd
      0.088   12.1   6.1        2.2    7.5   0.8    3.5  3  tRNA-synt_His  Histidyl-tRNA synthetase


Domain annotation for each model (and alignments):
>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   1.4    0.0031        14      16      54 ..     385     423 ..     378     435 .. 0.85
   2 ?   -0.9   0.8      0.58   2.6e+03      35      58 ..     475     498 ..     463     509 .. 0.51
   3 ?    8.6   0.1   0.00063       2.8      18      55 ..     584     621 ..     575     629 .. 0.86
   4 ?   -3.3   0.1       3.3   1.5e+04      32      45 ..     674     687 ..     662     695 .. 0.64
   5 ?   12.1   0.1   5.2e-05      0.23      12      65 ..     721     773 ..     720     773 .. 0.91
   6 ?   -0.6   0.2      0.49   2.2e+03      15      40 ..    1505    1530 ..    1500    1536 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0031
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXX CS
        SlyX  16 edtieeLndvvaeqqqqidrlqrqlrllaerlkeleess 54 
                 ++ i+eLn+++ +    +d    ++r l + +++ ++++
  EFC36670.1 385 DENIKELNQILLQTKNALDDRDNEIRNLLNSINTFQADT 423
                 568**************************9998888765 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.58
                 HHHHHHHHHHHT-XXXXXXXXXXX CS
        SlyX  35 rlqrqlrllaerlkeleessgase 58 
                 +l+++ ++++++l++l++ ++a+ 
  EFC36670.1 475 QLEKENEKIKRELSALQNIQKAQA 498
                 455555555555555555554333 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00063
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXX CS
        SlyX  18 tieeLndvvaeqqqqidrlqrqlrllaerlkeleessg 55 
                 ++ +L +++   +++i++l++ql++ + ++k+ e+ ++
  EFC36670.1 584 VVSQLKKQIRSKEKRITKLTAQLDEAQAKIKDFEDPEK 621
                 5789999***********************99998765 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 3.3
                 HHHHHHHHHHHHHH CS
        SlyX  32 qidrlqrqlrllae 45 
                 +i+ l+++lr+l+e
  EFC36670.1 674 KIEDLTTRLRELNE 687
                 45555555555554 PP

  == domain 5  score: 12.1 bits;  conditional E-value: 5.2e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXXXXXXXXX CS
        SlyX  12 lafqedtieeLndvvaeqqqqidrlqrqlrllaerlkeleessgaseaeeepPP 65 
                 l+ qe  i +L+++ ++ + +i++l  ++ +l+ ++++l+++ ++++ +  +PP
  EFC36670.1 721 LTVQESHILDLSNENIKLNTEITKLLSKISYLRSEISDLQSDLAEKN-KAVIPP 773
                 688***************************************88655.777777 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.49
                  HHHHHHHHHHHHHHHHHHHHHHHHHH CS
        SlyX   15 qedtieeLndvvaeqqqqidrlqrql 40  
                   e+++++L ++ + q  +i++ +r l
  EFC36670.1 1505 KEELLQQLEEEETSQYYDIKQNTRSL 1530
                  58999999999999999999998876 PP

>> Serine_rich  Serine rich protein interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1    0.0072        32      20      91 ..      98     168 ..      79     212 .. 0.84
   2 ?    9.2   1.0   0.00025       1.1      88     145 ..     387     444 ..     384     449 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0072
  Serine_rich  20 avskLlsfvsskWRskenleanlqeirlavdrlrtslrefleFargalanaaklsdknlqtkLrkqlqkled 91 
                  + s Ll  +s+k++s++ l+ n+ + ++a+++++t l++ +   +  +  a++++dk++ +kL ++   + +
   EFC36670.1  98 SPSPLLLPLSTKFKSQKILNTNTPQFQSALKEIKT-LKNQAPTKETLRRVAHEIKDKKIIAKLAQLHLDVVE 168
                  44668888899**********************86.7888999999999**************998665554 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00025
  Serine_rich  88 kledsdqilqetsqeLdsceWslealasdkkqekpddlDrlvmvartvpdDvkqlasf 145
                  ++++ +qil +t+++Ld+ + ++  l ++ ++ + d+ ++l   ++t +d +++l+ +
   EFC36670.1 387 NIKELNQILLQTKNALDDRDNEIRNLLNSINTFQADTFEKLKKHSQTNTDLIEKLMET 444
                  68999**********************************************9999875 PP

>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1     2e-05     0.088      60     125 ..     130     195 ..     108     210 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2e-05
                    EE-SSSHHHHHHHHHSHCCC--TT-EEEE-S---HHHHHHHHHHHHHTT-EEEEEEEESHHHHHHH CS
  NAD_binding_2  60 itmvkagkavdeviegllealkkgdilidgstsspedtrelakelkekglkfldaPVSGGeegAek 125
                    i  +k++++++e+++++++++k  +i+   +  + +  +++ ke+ke+g++f + + +G ++    
     EFC36670.1 130 IKTLKNQAPTKETLRRVAHEIKDKKIIAKLAQLHLDVVEQRRKEAKEQGVTFSEFGATGKVATDDD 195
                    55799************************************************9999998876555 PP

>> tRNA-synt_His  Histidyl-tRNA synthetase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.1      0.13   5.6e+02     212     263 ..     120     173 ..     105     191 .. 0.62
   2 ?    7.5   0.8   0.00048       2.2     154     236 ..     421     503 ..     413     511 .. 0.80
   3 ?    4.6   0.0    0.0038        17     146     194 ..    1443    1491 ..    1436    1535 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.13
                    CCHHHHCHCCHCTHHHHHHHHHHHHHHHHHHHHHHH..H-TTEEE-TT--TTTT CS
  tRNA-synt_His 212 aevleealealaaapalqaaldeleelaallealak..pevrvtlDlaelrgye 263
                      + + al+++ + ++ +  +++l+++a  +++ +   + ++++lD++e+r+ e
     EFC36670.1 120 TPQFQSALKEIKTLKNQAPTKETLRRVAHEIKDKKIiaKLAQLHLDVVEQRRKE 173
                    445555555555555555566666666666665433534478888888887654 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.00048
                    TCHHHHHHHHTT--HHHHHHHHHHHHCT-HHHHHHHHHCCTTHHHCCH.CC....HCCHCCCHHHHCHCCHCTHHHHHHHHHHHH CS
  tRNA-synt_His 154 vglvralleaaglsesleeallaalarkdlaelkelaaeaglkealre.llkal.elygdaevleealealaaapalqaaldele 236
                    ++ +++l ++ + + +l e+l++  ++ + ++ ++l++++++++++++ ll+++ +l++++e+++++l+al++ +++qa+  ++e
     EFC36670.1 421 ADTFEKLKKHSQTNTDLIEKLMETANAFKFKA-QRLYGDNNIPHDQYQsLLDKAlQLEKENEKIKRELSALQNIQKAQAM-VAME 503
                    56788999999999999999999999999999.6777777887776551666669**************99999887654.4444 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.0038
                     SEEEEEEETCHHHHHHHHTT--HHHHHHHHHHHHCT-HHHHHHHHHCCT CS
  tRNA-synt_His  146 elrldlghvglvralleaaglsesleeallaalarkdlaelkelaaeag 194 
                     + +l ++ ++l+++l ++++ls+s +++ l+al + +  +l++++ + +
     EFC36670.1 1443 GASLTITTPTLFKSLGQHIELSNSSKQKRLEALMKEEQDRLEKVLTSWN 1491
                     67899*************************************9998743 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1767 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2435  (0.135813); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.14u 0.30s 00:00:01.44 Elapsed: 00:00:00.49
# Mc/sec: 10850.24
//
Query:       EFC36671.1  [L=698]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0074   15.9   0.3       0.02   14.5   0.3    1.7  1  DUF4796         Domain of unknown function (DUF4796)
  ------ inclusion threshold ------
      0.053   13.9   4.8         16    6.0   8.5    2.8  2  CENP-B_dimeris  Centromere protein B dimerisation domain


Domain annotation for each model (and alignments):
>> DUF4796  Domain of unknown function (DUF4796)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.3   2.2e-06      0.02     105     176 ..     457     530 ..     427     541 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 2.2e-06
     DUF4796 105 lvekvseslleqwdevLeqv.sseekwsk.erYeeeshnCydfvLeflkalklaelkkalskeeftekfilprt 176
                  v +v +   +++d+++ q+ +  +kw+  + Y+ +s nC +fv ++l++l+l+++ +++ +++ + k  ++++
  EFC36671.1 457 FVLDVATIRSDNLDQMFLQIaQVVSKWNIyHLYNTRSCNCQHFVTDLLQTLHLESIFDKKINQNTCVKQFFKKV 530
                 55556666677899988887466788*99577*********************999955555555555555554 PP

>> CENP-B_dimeris  Centromere protein B dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   8.5    0.0018        16      18      48 ..     210     240 ..     201     258 .. 0.67
   2 ?    0.4   0.0     0.093   8.3e+02      24      84 ..     366     429 ..     362     431 .. 0.72

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0018
  CENP-B_dimeris  18 eeeeeeeedeededeeddedddevpvpsfge 48 
                     e+++ee+++eede+ +  + ++ev v  + e
      EFC36671.1 210 EDDNEEDDEEEDENSDSTDKNQEVSVGDYVE 240
                     3344444444455555555677898887766 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.093
  CENP-B_dimeris  24 eedeededeeddedddevpvpsfgeamayfamvkryltsfpid...drvqshilhlehdlvhvt 84 
                     +  +++++++ + + +   v s g+ +  +  +k  +t +  +    r+ s +++ +  lvhv+
      EFC36671.1 366 NSTNNNNNNNTNSNTNSNNVISNGNQFKEYVKIKFVITDLTFNrylKRLSSGLIKSKFGLVHVA 429
                     4445555666666777778899999999999999888877765333688899999999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (698 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1933  (0.107814); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 4123.50
//
Query:       EFC36672.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.7e-34  119.0   0.0    2.6e-34  118.4   0.0    1.3  1  adh_short     short chain dehydrogenase
    2.9e-23   82.6   0.0      4e-23   82.2   0.0    1.1  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    8.4e-08   32.3   0.0    1.2e-07   31.8   0.0    1.2  1  KR            KR domain
  ------ inclusion threshold ------
      0.016   15.3   0.1      0.037   14.1   0.1    1.5  1  DUF3906       Protein of unknown function (DUF3906)
       0.11   12.2   0.2       0.34   10.6   0.1    1.8  2  KRE1          Killer toxin-resistance protein 1


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.4   0.0   7.3e-38   2.6e-34       2     190 ..       3     202 ..       2     207 .. 0.87

  Alignments for each domain:
  == domain 1  score: 118.4 bits;  conditional E-value: 7.3e-38
                 EEEEESTTSHHHHHHHHHHHHT.....T-EEEEEESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGG CS
   adh_short   2 vvlvtGassGIGraiakelake.....GakvvvvdrseekleevakelkeegakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfse 95 
                 ++lvtG+++GIG+++a +l ke      ++++v++rs++  e++ ++lkeeg ++ ++++D+++ +++ +l +++++k+gk+d+L+nNA++  s+p ++
  EFC36672.1   3 IALVTGGTKGIGLQVALQLGKEkfyneSIHIIVTARSPN--EQAFTQLKEEGISYEYLPLDLASDQSIFDLKKTIKEKYGKIDILINNAAV-ASSPKKD 98 
                 69**************98877611111578899999977..77************************************************.6788888 PP

                 CSHHH.HHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-TT........BHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSH CS
   adh_short  96 lseee.wervievNltgvflltravlpamlkqssGrIvnvsSvagkvpvag........vaaYsAsKaavagltrslakelaptgirvnavaPGlvdTd 185
                  s ++ + ++++vN+ +v  ++ ++ + + +++  rIvnvsS+ g  +va+        ++ Y+ +K a+++lt   ++ +a+ +i+vna +PG+++T+
  EFC36672.1  99 PSLRDsYLDIYSVNVAAVAIIMDEFKELLEQSKHPRIVNVSSTLGSLAVAQlpnspqklYTTYTITKSALNMLTIIYSQKFAEFNIKVNATCPGYCATE 197
                 888888**************************************987665411122222679************************************* PP

                 HHHHH CS
   adh_short 186 makel 190
                 ++  +
  EFC36672.1 198 LNGYQ 202
                 99765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.2   0.0   1.1e-26     4e-23       4     198 ..      11     220 ..       7     227 .. 0.81

  Alignments for each domain:
  == domain 1  score: 82.2 bits;  conditional E-value: 1.1e-26
                   TSHHHHHH.....HHHHHTT-EEEEEESSGGHHHHHHHHHHHTTSE.EEE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EG.CSS-GGGH-HH CS
  adh_short_C2   4 sgIGraiA.....kalaeeGaevvltdlneeakkrveelaeelgae.vlecDVtdeeqvealveevvekfgklDilvnnagiapk.lkgpfletsre 93 
                   +gIG ++A     +++ +e  ++++t ++ ++ ++ ++l+ee+ +  +l++D ++++++ +l ++++ek+gk+Dil+nna++a + +k       r+
    EFC36672.1  11 KGIGLQVAlqlgkEKFYNESIHIIVTARSPNE-QAFTQLKEEGISYeYLPLDLASDQSIFDLKKTIKEKYGKIDILINNAAVASSpKK---DPSLRD 103
                   79999999333333566778899999999998.788899988766659************************************9333...346789 PP

                   HHHHHHHHHTHHHHHHHHHHHHHCTSC..CEEEEEEEGGGTSBSTT........TTHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTG.. CS
  adh_short_C2  94 efdraldvnlyslfllakaalplmkeg..gsivnlssvgaervvpn........ynaygaaKaalealtrylAvelgpkgiRvNavspgpikTla.. 178
                   ++ ++ +vn+ +++ ++ ++++l++++   +ivn+ss+ ++ +v++        y+ y+++K al+ lt     ++++ +i+vNa +pg+ +T++  
    EFC36672.1 104 SYLDIYSVNVAAVAIIMDEFKELLEQSkhPRIVNVSSTLGSLAVAQlpnspqklYTTYTITKSALNMLTIIYSQKFAEFNIKVNATCPGYCATELng 200
                   9*********************998776899******98887765423344344669************************************9944 PP

                   GGGSTTHHHHHHHHHHHSTT CS
  adh_short_C2 179 asgikgfdelleelearapl 198
                    +g k  +e  + + ++a +
    EFC36672.1 201 YQGTKTPQEGAKVIVRMALI 220
                   45555566666666666555 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.8   0.0   3.3e-11   1.2e-07       4     114 ..       5     114 ..       3     150 .. 0.77

  Alignments for each domain:
  == domain 1  score: 31.8 bits;  conditional E-value: 3.3e-11
                 EEETTTSHHHHHHHHHHHH....HHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE---------TT CS
          KR   4 litGGlGgLGlelarwlae....kgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvlrdklle 98 
                 l+tGG+ g+Gl++a +l +    +   h+++++Rs      +++ +++l++ g++ e++++D+++ +++  l ++ik++ ++i   i+ A v+   + +
  EFC36672.1   5 LVTGGTKGIGLQVALQLGKekfyNESIHIIVTARS-----PNEQAFTQLKEEGISYEYLPLDLASDQSIFDLKKTIKEKYGKIDILINNAAVASSPKKD 98 
                 9****************984443457799999999.....23457899*****************************************9998766555 PP

                 T--HHHHHHHHTTTTH CS
          KR  99 emtaedleqvlapKvk 114
                     +++  +++  v+
  EFC36672.1  99 PSLRDSYLDIYSVNVA 114
                 5555555555555555 PP

>> DUF3906  Protein of unknown function (DUF3906)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.1     1e-05     0.037      12      57 ..      28      75 ..      24      78 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1e-05
     DUF3906 12 eetvsvvvvAen.deqAFrqleie.lekhylklPevkevallEkKrir 57
                +e ++++v A + +eqAF ql +e +   yl+l    + ++++ K+  
  EFC36672.1 28 NESIHIIVTARSpNEQAFTQLKEEgISYEYLPLDLASDQSIFDLKKTI 75
                7899******8758*****9966549999***9999999999988755 PP

>> KRE1  Killer toxin-resistance protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.3   4.7e+03      20      33 ..      35      48 ..      33      51 .. 0.78
   2 ?   10.6   0.1   9.6e-05      0.34       5      38 ..     153     187 ..     150     193 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.3
        KRE1 20 ttvqttYsQsFsst 33
                +t++++ +Q F++ 
  EFC36672.1 35 VTARSPNEQAFTQL 48
                68889999999976 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 9.6e-05
        KRE1   5 spTsvwvTvt.snGklttvqttYsQsFsstyteva 38 
                 sp + ++T t ++ +l  +  +YsQ+F+++  +v+
  EFC36672.1 153 SPQKLYTTYTiTKSALNMLTIIYSQKFAEFNIKVN 187
                 5667899***99****************9988877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1630.28
//
Query:       EFC36673.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-37  127.9   0.3    4.2e-29  101.9   0.0    2.1  2  LCAT           Lecithin:cholesterol acyltransferase
    0.00058   19.4   0.0     0.0016   18.0   0.0    1.7  2  DUF676         Putative serine esterase (DUF676)
     0.0077   15.9   0.2      0.022   14.4   0.0    1.9  3  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.013   14.8   0.0      0.026   13.8   0.0    1.4  1  Hydrolase_4    Serine aminopeptidase, S33
      0.035   13.5   0.0       0.14   11.4   0.0    1.9  2  DUF915         Alpha/beta hydrolase of unknown function (DUF9
      0.086   12.5   0.1       0.34   10.6   0.0    1.9  2  PGAP1          PGAP1-like protein
      0.094   12.5   0.0        0.4   10.5   0.0    1.9  2  Palm_thioest   Palmitoyl protein thioesterase


Domain annotation for each model (and alignments):
>> LCAT  Lecithin:cholesterol acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.9   0.0   1.6e-32   4.2e-29       5     249 ..      99     349 ..      97     363 .. 0.81
   2 !   24.5   0.1   5.5e-09   1.4e-05     296     390 ..     364     450 ..     351     452 .. 0.85

  Alignments for each domain:
  == domain 1  score: 101.9 bits;  conditional E-value: 1.6e-32
        LCAT   5 elWldldmllslvvd.cwlknlelvldkstgl.qedapgvki..RadqGfeaieyldkskiagkqyeiwkklvknlvkiG.yeknktvvaapYDWRls. 97 
                 ++W +l+ l++ +++ c ++++ + l  + gl  ++  gvki  +  +G+   e    ++ + k y   k+l + lv++G y+ +k++++   DWRl  
  EFC36673.1  99 QIWISLEELVPYFTEdCFVHDMSIEL--KDGLlRQKDQGVKIfgKDIGGMGGLESV-LAQFESKAY-YMKSLSDYLVQNGnYQIGKSLRGLTMDWRLGv 193
                 7**********99877****766643..3333134778999988555666555555.344555555.589999*******9999**************9 PP

        LCAT  98 ......leerdkYfskLkelieealk.lsgkkvvliaHSmGnllvlyflkwveaeaWvdqhikafislgapllGsvkavkallsGenkgipvlseltlr 189
                       ++     f +Lkel+e ++k +++kkv l++HSmG+  + yfl   +++ W++++i+ fi +++++ Gs+ a+ + + G n gip ++ +++r
  EFC36673.1 194 rewasrNNSIGGDFFNLKELVEDTYKiNGNKKVSLLGHSMGGPFLQYFLATFVDQPWKEKFIDNFIPMAGAFDGSPLALILYVTGTNWGIPTFELSNAR 292
                 9975543333334679**********99*********************************************************************** PP

        LCAT 190 vlsksfssslsllPkgeevlwkdvawp.sdeiliqtpsinltegalvrffsdevdlkdlls 249
                 ++ +  +s l++ P   + +  +  +   +  +++ ps++++  ++ r+fsd  ++ + ++
  EFC36673.1 293 KIVRQYASPLFMSP---NYFPYNYPFFtYNRNNVSGPSYRINLPDIERYFSD-AQIANGIN 349
                 **************...66666665552566678999999999999999998.55555444 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 5.5e-09
        LCAT 296 eaPgvkvyciygvglptergyvyapekkssplnyilsdidyeteesivskdGdetvpkeslelCkkWqdnkakvkvtvaelkeekrsaehvellv 390
                  aP+v ++c yg g+ t   + y  +k+   l +   d+  +  +++ ++dGd+tvp  sl++C++ + +++k  v  +      +  +h+ ++ 
  EFC36673.1 364 AAPNVTTHCFYGYGVHTITHMEYSGSKE---LHDLDFDDLWKGMKVLNIEDGDGTVPAYSLQICDEFA-KYQKHAVYQHRF----FNTSHIGIVL 450
                 58*********************99954...45554568899999999********************.999999999888....7777777765 PP

>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   6.4e-07    0.0016      65     124 ..     211     263 ..     209     293 .. 0.78
   2 ?   -2.3   0.0      0.98   2.5e+03     119     146 ..     440     464 .]     424     464 .] 0.77

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 6.4e-07
      DUF676  65 eevlevvkkkkdknkkiSfvghSlGgliaraaiaklkekemtlkeaikglepvtfitlas 124
                 +e++e ++k + + kk+S++ghS+Gg++ ++ +a   +++ + k +     + +fi +a+
  EFC36673.1 211 KELVEDTYKINGN-KKVSLLGHSMGGPFLQYFLATFVDQPWKEK-F-----IDNFIPMAG 263
                 5666766666666.8*******************9998876423.3.....345666655 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.98
      DUF676 119 fitlasPhLGvlysskslinlglallek 146
                 f  +++ h+G++ ++k+ +++ l++l+k
  EFC36673.1 440 F--FNTSHIGIVLDEKV-FESLLQVLKK 464
                 4..6899****999999.8888888775 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.5   3.8e+03       2      16 ..      64      89 ..      64      99 .. 0.68
   2 !   14.4   0.0   8.7e-06     0.022      56      95 ..     207     247 ..     117     272 .. 0.79
   3 ?   -3.6   0.0       2.7     7e+03     220     251 ..     411     446 ..     396     450 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.5
                   EEEEE-STTTCGGG...........G CS
  Abhydrolase_1  2 vlvilhGlpgssdv...........w 16
                   +l+i+ Gl+gs+ +           w
     EFC36673.1 64 PLIIVGGLGGSALMsqrnnavkephW 89
                   68999999998777544444444444 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 8.7e-06
                    HHHHHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHHH.G CS
  Abhydrolase_1  56 tasvaddldrildalgddkltlvGhSmGGmialayaaey.p 95 
                    ++++ + ++      g++k+ l+GhSmGG +  +++a + +
     EFC36673.1 207 FFNLKELVEDTYKINGNKKVSLLGHSMGGPFLQYFLATFvD 247
                    566777777777889**********************9962 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 2.7
                    TTCSSSCHHHHHHHHHC...HTS.EEEEEEETCSSS CS
  Abhydrolase_1 220 tsDplvppkaledlaql...lpk.krlvvisdagHl 251
                    + D+ vp  +l  +++     ++ ++ ++++++ H+
     EFC36673.1 411 DGDGTVPAYSLQICDEFakyQKHaVYQHRFFNTSHI 446
                    567777777777777666554446888888888887 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0     1e-05     0.026      62     113 ..     210     267 ..     184     301 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1e-05
  Hydrolase_4  62 laafvekvkeehpelplfllGhSmGGliallyl.....lrypd.kvaglilsaPalki 113
                  l+++ve   + ++++++ llGhSmGG   + +l     +  ++  ++ +i +a a++ 
   EFC36673.1 210 LKELVEDTYKINGNKKVSLLGHSMGGPFLQYFLatfvdQPWKEkFIDNFIPMAGAFDG 267
                  788999999999**************88777764443322222233366666666665 PP

>> DUF915  Alpha/beta hydrolase of unknown function (DUF915)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   5.5e-05      0.14      98     145 ..     216     267 ..     207     271 .. 0.74
   2 ?   -1.6   0.0      0.53   1.4e+03     186     229 ..     405     441 ..     387     460 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 5.5e-05
      DUF915  98 kkYni...kkfnavGhSmGglaltsYleeyadd...kslPqlkklvtiggpfng 145
                  +Y+i   kk+ ++GhSmGg  l ++l++  d+   +++  ++  + ++g f+g
  EFC36673.1 216 DTYKIngnKKVSLLGHSMGGPFLQYFLATFVDQpwkEKF--IDNFIPMAGAFDG 267
                 4666644479****************9988775222555..7777777777776 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.53
      DUF915 186 evlniaGdledgkqsDgivplasseslkyllkknaksyteslik 229
                 +vlni       +++Dg+vp  s +    + k + + + ++++ 
  EFC36673.1 405 KVLNI-------EDGDGTVPAYSLQICDEFAKYQKHAVYQHRFF 441
                 55555.......46899999999998888887776666666554 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00013      0.34      86     106 ..     219     239 ..     210     278 .. 0.72
   2 ?   -1.2   0.0      0.52   1.3e+03      24      58 ..     291     325 ..     271     360 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00013
       PGAP1  86 sekeptsviliGHSmGGivar 106
                 + + +++v l+GHSmGG   +
  EFC36673.1 219 KINGNKKVSLLGHSMGGPFLQ 239
                 557899***********6554 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.52
       PGAP1  24 Aseaaeayqelrkllknqnkkeldfftvdfneels 58 
                 A++  ++y++     +n  ++++ fft++ n+   
  EFC36673.1 291 ARKIVRQYASPLFMSPNYFPYNYPFFTYNRNNVSG 325
                 566667777777888999999999***99987655 PP

>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.38   9.6e+02       1      77 [.      64     145 ..      64     148 .. 0.68
   2 ?   10.5   0.0   0.00016       0.4      50     107 ..     209     269 ..     146     349 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.38
  Palm_thioest   1 PvviwhGl.....dsaesn.mqklaeliekligtyvknveigeseaedrkasffgnlndqvea.vckklelangfhaiGfSQGg 77 
                   P++i+ Gl      s+ +n +++   ++ek+ + +   ++++e     ++++f++++  ++++   ++  +++g+++ G   Gg
    EFC36673.1  64 PLIIVGGLggsalMSQRNNaVKEPHWWCEKSTDPFQIWISLEELVPYFTEDCFVHDMSIELKDgLLRQ--KDQGVKIFGKDIGG 145
                   677777775444333333355666666666656778888888888899999******99999954444..57899988877666 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00016
  Palm_thioest  50 nlndqveavckklelangfhaiGfSQGglflRaliercddkkn.....vrnlislggpqaGvf 107
                   nl++ ve+  k  + ++++ ++G+S Gg fl  ++ +  d+ +     ++n+i ++g   G  
    EFC36673.1 209 NLKELVEDTYKI-NGNKKVSLLGHSMGGPFLQYFLATFVDQ-PwkekfIDNFIPMAGAFDGSP 269
                   555666665555.68899*****************999554.458889*******99988864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       394  (0.0219756); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.45
# Mc/sec: 3091.62
//
Query:       EFC36674.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-12   46.5   0.0      4e-12   45.7   0.0    1.4  1  UDPGT            UDP-glucoronosyl and UDP-glucosyl transferas
    0.00011   22.2   0.0    0.00022   21.2   0.0    1.5  1  Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal dom


Domain annotation for each model (and alignments):
>> UDPGT  UDP-glucoronosyl and UDP-glucosyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.7   0.0   4.5e-16     4e-12     325     487 ..     396     565 ..     360     572 .. 0.77

  Alignments for each domain:
  == domain 1  score: 45.7 bits;  conditional E-value: 4.5e-16
       UDPGT 325 llvkWlPqndlLgHPktkAFvtHaGangvyEaisnGvPmvglPlFgdqrdNikrmeakgaavtlnvkemtsed.....llnAlkevindks....yken 414
                 +l  ++Pq  lL   k+k F tH Gan+v Ea++ G  ++g P+  dq+   + +e    + ++  ++  s+d     + +A++e++ d+     yk  
  EFC36674.1 396 ILKGFVPQKGLLSLEKVKIFFTHCGANSVNEALYFGKLLIGFPFAYDQMRVSHAIEEFKVGRSIYHSKKESSDwninsISKAVHELLYDEQtsdkYKTA 494
                 77789*********************************************9999998766666666555555422222567888888877511114444 PP

       UDPGT 415 imrLsslhkDrPvkPLDravfWiefvmrhkGAkhlRaaahdLtWyqyhsLDvigfllavvvtvafiivkeclf 487
                 + +   l   r    + ra   +e v   +G     +a + LtW+q++ LD+i f   ++ +++ +    c +
  EFC36674.1 495 ARHAKALT--RRSGGVSRAAEIVELVSEVDGDLSWGVADKHLTWWQFYCLDIILFYGIIIYFTIKMSKLICCY 565
                 44444333..4566899************************************99877766666555444444 PP

>> Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   2.5e-08   0.00022      72     154 ..     411     494 ..     399     514 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 2.5e-08
                      HH-EEEECS-CHHHHHHHHTT--EEEE--TT....S-HHHHHHHHHHHHHHSSEEEE-S...TTCHHHHHHHHCCS---S---SSC CS
  Glyco_tran_28_C  72 aadLvIsRAGagtiaEllalgkplIlvplpeaaenhqdnNakelekagaalvleqkelt...pekLeeallelaaeklrlaekska 154
                      + ++  ++ Ga++++E+l++gk lI +p+ +  ++    +a e  k g  +++ +ke +   + ++ +a+ el+ ++++  + ++a
       EFC36674.1 411 KVKIFFTHCGANSVNEALYFGKLLIGFPFAY--DQMRVSHAIEEFKVGRSIYHSKKESSdwnINSISKAVHELLYDEQTSDKYKTA 494
                      5678889************************..33555799999999999999999996565666666666666665553222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       636  (0.0354733); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 3608.19
//
Query:       EFC36675.1  [L=469]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-83  282.0   6.1    2.7e-83  280.7   6.1    1.5  1  Peptidase_S10  Serine carboxypeptidase


Domain annotation for each model (and alignments):
>> Peptidase_S10  Serine carboxypeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  280.7   6.1   1.5e-87   2.7e-83      11     418 ..      76     465 ..      67     466 .. 0.89

  Alignments for each domain:
  == domain 1  score: 280.7 bits;  conditional E-value: 1.5e-87
                    EEEEEEECSTTTTEEEEEEEEE-SSGTTTS-EEEEE--TTTB-THHHHHHTTSSEEEETTTTSEEEE-TT-GGGCSEEEEE--STTSTT-EETTSS CS
  Peptidase_S10  11 qysGYldveeeedkslFYwfveseknpeedplvlWLnGGPGCsSldGlleElGPfrvnkdstkkleenpysWnkvanvlfldqPvGvGFSysntks 106
                    + sG+++v+++ + +++Y+f e+ + +++ p+++W++GGPG+ S  Gl+ E+GP+ v++ +t kl++np++Wn   ++++ld+P+G GFS  ++  
     EFC36675.1  76 EFSGFIEVNSTYKGQMYYVFSEALSGKADSPIIIWFQGGPGAGSEFGLFVENGPYLVDP-KTLKLVKNPTTWNYDYHMIWLDNPLGSGFSHVQSPG 170
                    689*******************************************************5.57****************************999866 PP

                    GS--SHHHHHHHHHHHHHHHHHH..STCGTTSEEEEEEETTHHHHHHHHHHHHHTHCCH--SSTSEEEEEEEESE-SBHHHHHCCHHHHHHHTTSS CS
  Peptidase_S10 107 dvktddeevaedlyefLkkffek..fpeyksrdfyitGESYaGhyvPalakeilkknkkekkkkinLkGlligNglideaeqvnsyvefayehgli 200
                     + +++++va++++ fL+kff+     +y+ +++y+ GESYaG+y+P +a +i+++        +nL G+ ig+gl+d+++q+ sy  +++  gli
     EFC36675.1 171 -YVHSEDRVASEVHIFLEKFFQLdfARKYRGNELYLFGESYAGKYIPSIAYNIMNSG-----FPFNLAGIGIGDGLTDPEIQFASYDTYSFATGLI 260
                    .689******************9755789*************************987.....479******************************* PP

                    HHHHHHHHHHHHEET..HHHHHHHHHHHHHHHHHHHHHHHHHCHCEETTETTSEETTSSEEHHHCTTCCCCTTTTTCHHHHHHHHTSHHHHHHTT- CS
  Peptidase_S10 201 seeeyeslkkacekk..eeleqesekcanllekaskvavekenkglnvynileeccklkaelkksstdaqggedpydesyvekylnkkeVrkalhv 294
                    +  + + +k+ +++      e++  +  n +++++  +++++ +g+nvy+i++                       d s++ +y+n +e +k +h 
     EFC36675.1 261 DGPQRAVVKNYQDQIvkLIKEKRFVDVMNVNNNLTDFVINQCAGGVNVYDIRSYG-------------------DPDISAYVQYVNLPETKKLMH- 336
                    *999998777775544322233445556666666666688888999999998777...................789999***************. PP

                    -TTSSS--SB-HHHHHHCTCCC-SBCHHHHHHHHHTT...-EEEEEEETT-STT-HHHHHHHHHHTECTTECCSCCC...EEEETTTCESEEEEEE CS
  Peptidase_S10 295 nasvkkweecndsvfeqleddisksveeileellesg...lrvliynGdvDlicnvlgteawikklelsgkkefrpw...evspkkengqvaGyvk 384
                     ++  k+ + n++v ++l  di+ksv++ +e ll+s    +rvl+ynG++D i+n +g  +wi++++++g++ f++     ++p+k++gq++Gy +
     EFC36675.1 337 -TEGVKYYDENNDVWNNLLADIAKSVKYKVEALLDSPerkVRVLLYNGQYDWIVNSVGATNWIQSMNWHGASSFNQDlglGRKPWKVDGQIVGYSH 431
                    .45677778888898999*************999876666**********************************9972224566************ PP

                    EETTEEEEEETT--SSHHHHSHHHHHHHHHHHHT CS
  Peptidase_S10 385 eyenltfltvkgaGHmvPedkpeealqllerfis 418
                    +y+nl  + v +aGHm P+++ ++ l++++ f++
     EFC36675.1 432 QYDNLVTILVNKAGHMSPMNQGKNVLEMVRTFTQ 465
                    ******************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (469 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       507  (0.0282782); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2794.55
//
Query:       EFC36676.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       958  (0.053433); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1888.73
//
Query:       EFC36677.1  [L=789]
Description: hypothetical protein NAEGRDRAFT_59947 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0032   17.3   0.1      0.016   15.0   0.0    2.4  2  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.038   14.4  15.3       0.97    9.9   0.0    6.7  7  LRR_4       Leucine Rich repeats (2 copies)
      0.048   13.7   3.2        1.4    9.0   0.4    2.9  2  PTR         Phage tail repeat like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   2.8e-06     0.016       1      46 [.       6      61 ..       6      63 .. 0.83
   2 ?   -2.8   0.0         1     6e+03       7      15 ..     608     616 ..     607     628 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 2.8e-06
  F-box-like  1 isrLPdEiLlqIFsyL.ppsd.........LlrlalVCrrWrrvaldtplLWrrlv 46
                i +LP Ei  +IF yL p  +         Ll+++++ r  r+  +++ ++W+ ++
  EFC36677.1  6 IEDLPYEIFDHIFYYLlPSAEtrkvtgfndLLAISHTNRALRERMRNNSFFWSSVF 61
                579**********88756444566666666**********************9987 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1
  F-box-like   7 EiLlqIFsy 15 
                 ++L +IFs 
  EFC36677.1 608 DLLHDIFSK 616
                 68999**95 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1       0.2   1.2e+03      17      33 ..     226     243 ..     220     252 .. 0.64
   2 ?   -1.8   0.2      0.79   4.7e+03      16      28 ..     274     287 ..     259     302 .. 0.65
   3 ?    5.6   0.1    0.0037        22       1      27 [.     352     377 ..     352     394 .. 0.81
   4 ?   -2.1   0.1         1   6.2e+03      27      39 ..     512     522 ..     511     527 .. 0.58
   5 ?    0.2   0.0      0.19   1.1e+03      16      28 ..     577     589 ..     568     606 .. 0.69
   6 ?    2.1   0.1     0.047   2.8e+02      20      30 ..     635     647 ..     616     653 .. 0.64
   7 ?    9.9   0.0   0.00016      0.97       1      35 [.     659     694 ..     659     710 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.2
                 S-HHH-TT--EEE-..-S CS
       LRR_4  17 plleklpnLkeLdL.sgN 33 
                 +++++l +L+++ L s++
  EFC36677.1 226 ESCKNLSKLETVELcSEC 243
                 345568888888875665 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.79
                 -S-HHH.-TT--EE CS
       LRR_4  16 ipllek.lpnLkeL 28 
                 +++ +k  pnL++L
  EFC36677.1 274 LENWNKlAPNLTVL 287
                 34434444666666 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0037
                 SS--EEE--.SS---E-S-HHH-TT--E CS
       LRR_4   1 pnLevLdLs.nNqltdiplleklpnLke 27 
                 p+L++LdL+ ++ +t+ +    +pnL+ 
  EFC36677.1 352 PKLKKLDLQiSCVITENQK--PFPNLEC 377
                 79*********9***7444..3788875 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 1
                 EEE-.-S-----G CS
       LRR_4  27 eLdLsgNnlitdl 39 
                 ++++sgN  i++l
  EFC36677.1 512 HIHISGN--ISNL 522
                 5667776..5555 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.19
                 -S-HHH-TT--EE CS
       LRR_4  16 iplleklpnLkeL 28 
                 ++ +++l+nLk +
  EFC36677.1 577 LSQFSNLKNLKIV 589
                 3445556776654 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.047
                 H..H-TT--EEE- CS
       LRR_4  20 e..klpnLkeLdL 30 
                 +  ++++L++L+L
  EFC36677.1 635 SlhSFTSLQYLYL 647
                 2447999****99 PP

  == domain 7  score: 9.9 bits;  conditional E-value: 0.00016
                 SS--EEE--SS---E-S-.HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl.leklpnLkeLdLsgNnl 35 
                 pnL++L  + +++   +  l ++++L+++ ++++++
  EFC36677.1 659 PNLKILEMNRCNIEGAEVdLTGMTQLQSIKIWDMSY 694
                 8*************99998999*******9988755 PP

>> PTR  Phage tail repeat like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.4   0.00024       1.4      24      41 ..     507     524 ..     501     539 .. 0.65
   2 ?    4.0   0.1    0.0088        53      11      40 ..     711     740 ..     702     748 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00024
         PTR  24 KadkgHTHtIanItnLqe 41 
                 K+ k+H H   nI nL++
  EFC36677.1 507 KSSKTHIHISGNISNLEL 524
                 666666666666666665 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.0088
         PTR  11 IanitnLqetLnrKadkgHTHtIanItnLq 40 
                 ++ i++L+ +L  K+ k     I +I  L 
  EFC36677.1 711 VYSIKELKSKLSIKSKKLRSFIITKIGKLA 740
                 689**************9999999998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (789 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 4619.82
//
Query:       EFC36678.1  [L=416]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.065   13.2   1.2       0.12   12.3   1.2    1.5  1  Colicin_im  Colicin immunity protein


Domain annotation for each model (and alignments):
>> Colicin_im  Colicin immunity protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.2   6.9e-06      0.12      13      85 ..      11      82 ..       2     143 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.9e-06
  Colicin_im 13 enlPsitslynPlltkvmdiYvktaPllalilfiltfktrelikktsrklvlkslllsallyavliYllllrn 85
                 nlPs+ s+    ++ ++++ + t   +a   fi+ +   ++ k ++   +  +++ + +l+ +++Y +ll  
  EFC36678.1 11 YNLPSFFSITSGGVSYIVSVSNYTNENIAWRQFIIVYSD-DISKTAHNSIIASICVAFGILVFSVLYRILLSR 82
                58***********************************75.78888888888899*************999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1088  (0.0606838); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.24s 00:00:00.75 Elapsed: 00:00:00.40
# Mc/sec: 3088.17
//
Query:       EFC36679.1  [L=671]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      3e-06   27.0   0.4    6.9e-06   25.9   0.4    1.6  1  F-box-like  F-box-like
    0.00032   20.5   0.3    0.00092   19.0   0.3    1.7  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.4   7.7e-10   6.9e-06       2      35 ..      30      64 ..      29      68 .. 0.91

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 7.7e-10
  F-box-like  2 srLPdEiLlqIFsyLppsdLlr.lalVCrrWrrva 35
                sr P+E+L  I syL+++++   + +VC++Wr+++
  EFC36679.1 30 SRVPPEVLYSIISYLDFRSIMMiIPRVCSSWREII 64
                688****************999569********98 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.3     1e-07   0.00092       4      37 ..      30      64 ..      29      72 .. 0.96

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 1e-07
                HHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHH CS
       F-box  4 srLPsevlrhILerLplsd.llalrrVSkgwrili 37
                sr+P+evl  I+++L++++    + rV+ +wr +i
  EFC36679.1 30 SRVPPEVLYSIISYLDFRSiMMIIPRVCSSWREII 64
                8*******************************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (671 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       961  (0.0536003); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.25s 00:00:00.93 Elapsed: 00:00:00.46
# Mc/sec: 4398.55
//
Query:       EFC36680.1  [L=478]
Description: citrate synthase family member [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   7.4e-133  443.1   0.0   8.9e-133  442.8   0.0    1.0  1  Citrate_synt  Citrate synthase, C-terminal domain


Domain annotation for each model (and alignments):
>> Citrate_synt  Citrate synthase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  442.8   0.0    5e-137  8.9e-133       1     361 []      58     436 ..      58     436 .. 0.95

  Alignments for each domain:
  == domain 1  score: 442.8 bits;  conditional E-value: 5e-137
                   GGTTEEEEEESSEEEETTTTEEEETTEEHHHHHHHHS-HHHHHHHHHHSS---HHHHHHHHHHHHCTTS--HHHHHHHHCSSTTS-HHHHHHHHHHH CS
  Citrate_synt   1 glrgvaaleteisevdgekgelrYRGydieeLaeekssfeevaylLltgelPtkeelkefkeelaearklpekvlealealpkdahpmavlraavsa 97 
                   g++++a+ +++is++dgekg+lrYRGydieeLa ekssf eva+lL++gelP++++l+ ++e++++++ l+e+++  l++++ dahpm +++++++a
    EFC36680.1  58 GFMNTAISRSSISYIDGEKGILRYRGYDIEELA-EKSSFLEVAFLLINGELPDRNQLNLWEERVTKHSYLHENMVTLLKQFRYDAHPMGMVISSIAA 153
                   7899*****************************.8************************************************************** PP

                   HHHHSTT...................CTCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS.--.---TTSSHHHHHHHHHHS.....S---HHHH CS
  Citrate_synt  98 lsaddee...................seakeeseeaalrdalkliAklptiaaaiyrarlgrepl.epddklsyaenflymlrg.....kkpdeeea 169
                   +++++e+                    + ++ + ++++r    +++klptiaa +yr+r g+ p+ +p ++l+y+ nflyml++     ++p++ +a
    EFC36680.1 154 MGTFYEDanpslqgsdlflkgadkdcVKVDSLRFKQIYR----ILGKLPTIAASAYRHRIGK-PYnNPVNNLNYTGNFLYMLDRlsevnYHPNPVLA 245
                   ******9*********99976544433333336666777....*****************96.88788899***********9788999******** PP

                   HHHHHHHHHHS--SSSHHHHHHHHHHTTT--HHHHHHHHHHHHTSTTTTTHHHHHHHHHHHHSSGG.GHHHHHHHHHHTTTS--TTBC-SSSSS--H CS
  Citrate_synt 170 klldlalvlhaDHelnaSTfaarvvaStladlysaiaagigalkGplhgganeavlkmleeigsaeveveeylekvlakekerlpGfGHrvykksDp 266
                   ++l++++++ha+He+n+ST+a+r+++S+++d+y++ia++ gal+Gplhgga+eavl+mleeig++e ++++++e+v+++ k++l+GfGHr+y+++Dp
    EFC36680.1 246 RALEKLWIIHAEHEMNCSTAAMRHLSSSRVDPYTSIAGASGALYGPLHGGACEAVLHMLEEIGTKE-NIPKFIEEVKQR-KKKLMGFGHRIYRSYDP 340
                   *****************************************************************9.*********997.7**************** PP

                   HHHHHHHHHHHHHTCHTHHHHHHHHHHHHHHHHHHHHCHHGCT-EB-THHHHHHHHHHTT--GGGHHHHHHHHHHHHHHHHHHHHHHT..------E CS
  Citrate_synt 267 RakilkelaeelaeekgkdpllklaeeleevapevlkekeeknlypNvDfysgvlyralgipeelftvlfaisRvaGwlAhileqlad..nkiiRPr 361
                   Raki+k++a+e+++  gk+p++++a ele++a +++++ke ++lypNvDfy+g++y+ lg+p ++++vlf i R+aGwlAh++e l+d   ki+RP+
    EFC36680.1 341 RAKIVKKVADEVFQVLGKEPMIEIAVELEQIALNDPYFKE-RKLYPNVDFYTGLVYKCLGFPADYYPVLFLIPRCAGWLAHWIESLEDpeVKIFRPK 436
                   ****************************************.*******************************************98654589****7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (478 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.38
# Mc/sec: 3753.91
//
Query:       EFC36681.1  [L=1319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-09   38.6   2.4       0.02   15.8   0.0    6.0  5  WD40         WD domain, G-beta repeat
    1.6e-05   25.1   4.9      0.067   13.5   0.1    5.6  7  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    9.1e-05   22.2   0.0    0.00049   19.9   0.0    2.4  2  Sec16_C      Sec23-binding domain of Sec16
  ------ inclusion threshold ------
       0.24   11.3   1.9        0.4   10.5   0.1    2.4  2  Clathrin     Region in Clathrin and VPS


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.74   3.3e+03      25      38 .]     174     188 ..     158     188 .. 0.73
   2 !   15.8   0.0   4.4e-06      0.02       4      38 .]     210     246 ..     207     246 .. 0.87
   3 ?    2.8   0.1     0.056   2.5e+02      10      38 .]     264     295 ..     258     295 .. 0.73
   4 !   11.4   0.1    0.0001      0.46       8      38 .]     360     392 ..     350     392 .. 0.77
   5 ?    2.1   0.0     0.095   4.3e+02      13      37 ..     429     453 ..     412     454 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.74
                 EEEEE.TTSEEEEEE CS
        WD40  25 lasGs.dDgtvriWd 38 
                 +++G   Dgt+ ++d
  EFC36681.1 174 IVAGAqVDGTISLFD 188
                 5678745****9998 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 4.4e-06
                 EEEEESS.SSEEEEEEETTSSEEE.EEETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtslafspdgawla.sGsdDgtvriWd 38 
                 + tl+ H +sv++l f+p +  l+ s+++Dg + iW+
  EFC36681.1 210 VATLDKHqNSVRGLEFNPKQVNLLaSAGEDGQLFIWN 246
                 678999*999**********997526799*******8 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.056
                 S.SS.EEEEEEETTSSE.EEEEETTSEEEEEE CS
        WD40  10 H.ss.vtslafspdgaw.lasGsdDgtvriWd 38 
                 H +  +++l++++   + la+ s  gt  +Wd
  EFC36681.1 264 HqNQtISHLQWNQKFEYiLATTSHQGTSVVWD 295
                 653459999666666665566677*******9 PP

  == domain 4  score: 11.4 bits;  conditional E-value: 0.0001
                 ESS.SSEEEEEEETTSSE.EEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgaw.lasGsdDgtvriWd 38 
                  GH ++v s++++++ +  l+s+++D+   iW+
  EFC36681.1 360 QGHqKGVLSVSWCREDSNlLVSSGKDNRSLIWN 392
                 49*999****96666666357889********8 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.095
                 EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  13 vtslafspdgawlasGsdDgtvriW 37 
                 + + ++s  ++ l+++s D+++ ++
  EFC36681.1 429 IFDAQWSYKSTILSTSSFDKKIQVY 453
                 556668888889*99999****987 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.1   4.9e+03       1      19 [.      12      33 ..      12      45 .. 0.75
   2 !   10.0   0.1   0.00018      0.81      29      91 ..     210     276 ..     170     277 .. 0.69
   3 !   13.5   0.1   1.5e-05     0.067       3      90 ..     225     321 ..     223     323 .. 0.81
   4 ?    2.7   0.0     0.034   1.5e+02      27      65 ..     299     340 ..     281     349 .. 0.69
   5 !    6.1   0.0     0.003        13      32      79 ..     355     405 ..     339     415 .. 0.79
   6 ?   -0.6   0.0      0.37   1.7e+03      41      73 ..     429     461 ..     411     475 .. 0.79
   7 ?   -3.6   0.0       3.3   1.5e+04      37      69 ..     591     624 ..     583     634 .. 0.59

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.1
  ANAPC4_WD40  1 lswcp...tmDLiAlatedgel 19
                 lswcp   + DL+A+++  g+l
   EFC36681.1 12 LSWCPiqdHTDLMAVGSLAGSL 33
                 5899844456899998877766 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00018
  ANAPC4_WD40  29 vwtleedkedsevrsLaWkpdg.klLavaysdgevrlldaesgk....vvhsl.svksekavtclgWge 91 
                  v   + dk++++vr+L+++p+  +lLa a +dg++ + + ++ +    vv  + + +++++++ l+W++
   EFC36681.1 210 VA--TLDKHQNSVRGLEFNPKQvNLLASAGEDGQLFIWNLKQPEqpgvVVLGCkNPHQNQTISHLQWNQ 276
                  33..458999*********9875899*********9999887542211333331334445888888875 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 1.5e-05
  ANAPC4_WD40   3 wcpt.mDLiAlatedgellvfRlng.....qrvwtleedkedsevrsLaWkpd.gklLavaysdgevrlldaesgkvvhslsvksek..avtclgWg 90 
                  ++p+  +L+A a edg+l +  l+        v + +++++++++++L+W+++ + +La   ++g+  + d  +++v+  +s +++   + ++l W+
   EFC36681.1 225 FNPKqVNLLASAGEDGQLFIWNLKQpeqpgVVVLGCKNPHQNQTISHLQWNQKfEYILATTSHQGTSVVWDLRQKRVLVPFSNANHPrsRYSSLAWN 321
                  6664269*************9999866554556666**************9875789999999**************99988776654477778775 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.034
  ANAPC4_WD40  27 qrvwtl..eedkedsevrsLaWkpdgkl.Lavaysdgevrll 65 
                  +rv     +++++ s+ +sLaW+pd +  L va++d e  ++
   EFC36681.1 299 KRVLVPfsNANHPRSRYSSLAWNPDIHTqLLVACEDDERPVI 340
                  444433556677788899*******76449999999875555 PP

  == domain 5  score: 6.1 bits;  conditional E-value: 0.003
  ANAPC4_WD40  32 l..eedkedsevrsLaW.kpdgklLavaysdgevrlldaesgkvvhslsvk 79 
                  l  +++++++ v s++W ++d +lL+ + +d++  + + ++g+++ +ls++
   EFC36681.1 355 LgsAQQGHQKGVLSVSWcREDSNLLVSSGKDNRSLIWNPNTGDLLGELSTG 405
                  15568899999******77888999999**************999888776 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.37
  ANAPC4_WD40  41 vrsLaWkpdgklLavaysdgevrlldaesgkvv 73 
                  + + +W+ + ++L  +  d +++++++++   v
   EFC36681.1 429 IFDAQWSYKSTILSTSSFDKKIQVYSVQDPSSV 461
                  5567899******************99986655 PP

  == domain 7  score: -3.6 bits;  conditional E-value: 3.3
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdg.evrlldaes 69 
                  ++se +s++W+  + l+    ++g +++ l  ++
   EFC36681.1 591 KQSESQSMEWNLLEILFTSDEEKGkKIQSLLGYN 624
                  5555566666666666655555554455555555 PP

>> Sec16_C  Sec23-binding domain of Sec16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   1.1e-07   0.00049       1      51 [.     654     705 ..     654     798 .. 0.74
   2 ?   -2.8   0.0      0.84   3.8e+03     253     302 .]    1189    1235 ..    1181    1235 .. 0.64

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 1.1e-07
                 HHHHHHTT-HHHHHHHHHHTT-HHHHHHHHHTS-.HHHHHHHHHHHHH---. CS
     Sec16_C   1 iqalLlrGdrekAlqlAldkklWahAlliasllg.kelwkevvqefvrselk 51 
                 i++ ++ G+ + A++++l+   ++ Al++a+  g +elw+ vv++f++s+ +
  EFC36681.1 654 IKKNIIVGNMQGAINCCLSGNRFSDALVLAKVTGnSELWNYVVEQFLNSKEG 705
                 678899*************************9973589*********99876 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.84
                  HHHHHHHHHHHT-XXX.....XXX..XXXXXXXXXXXXXXXXXXXXXXXX CS
     Sec16_C  253 lleqlkdLserLseapkedksssWlkiskpsldkvwgsleksfnkfvaGd 302 
                  +++q   L e L++    d +    +++  + ++v +sl +sf k+ +G+
  EFC36681.1 1189 VVDQQAILRENLEKYAGIDIER---NVTSARYQNVVDSLTQSFDKLYGGE 1235
                  5555555555555555433222...3566778899**********99997 PP

>> Clathrin  Region in Clathrin and VPS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.1     9e-05       0.4      82     140 ..     643     704 ..     582     706 .. 0.79
   2 ?   -2.4   0.2      0.87   3.9e+03      99     141 ..     719     761 ..     715     763 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 9e-05
                 T-SSHHHHHHHHHT...TXTHSSHSSXSSSSHCSCHHHHTTTTTXXSHHHHHHHHHHHSSXS CS
    Clathrin  82 kadlyeeavilykk...inefkkaisllkklkdfddaieyaakvsnpelwekllealldkkp 140
                 +++  ee+  l kk   +++ + ai+++   + f da+  a+   n+elw+ ++e +l++k+
  EFC36681.1 643 ERNNSEELSTLIKKniiVGNMQGAINCCLSGNRFSDALVLAKVTGNSELWNYVVEQFLNSKE 704
                 5667788888888888899***************************************9875 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.87
                 HSSHSSXSSSSHCSCHHH..HTTTTTXXSHHHHHHHHHHHSSXSH CS
    Clathrin  99 fkkaisllkklkdfddai..eyaakvsnpelwekllealldkkpf 141
                 ++ +++  ++++++++++    +   +n+ l + +l+ l++k+++
  EFC36681.1 719 YDAVLN--HTEESWKEKLatLCLDMTKNKTLIDSVLKSLVEKEEQ 761
                 444333..7777777777655666677788888888888887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1436  (0.0800937); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.98u 0.30s 00:00:01.28 Elapsed: 00:00:00.50
# Mc/sec: 7873.30
//
Query:       EFC36682.1  [L=227]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1410.13
//
Query:       EFC36683.1  [L=1111]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-30  104.8  19.8    7.8e-08   31.9   0.0    7.2  7  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    8.4e-29  100.0  11.3    2.7e-06   27.9   0.0    7.4  8  RCC1      Regulator of chromosome condensation (RCC1) repeat
    3.7e-05   23.9   3.7    7.7e-05   22.9   2.1    2.4  3  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.17     1e+03      20      29 ..      79      88 ..      77      89 .. 0.91
   2 !   15.1   0.0   2.4e-06     0.014       1      28 [.     126     153 ..     126     154 .. 0.96
   3 !   31.9   0.0   1.3e-11   7.8e-08       1      30 []     176     205 ..     176     205 .. 0.99
   4 !   22.3   0.3   1.4e-08   8.2e-05       1      29 [.     246     274 ..     246     275 .. 0.95
   5 !   23.4   0.2   6.1e-09   3.6e-05       3      30 .]     301     328 ..     299     328 .. 0.97
   6 !   13.2   0.5     1e-05     0.061       1      29 [.     352     381 ..     352     382 .. 0.85
   7 !    6.9   0.5   0.00095       5.7       2      29 ..     404     430 ..     404     431 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.17
      RCC1_2 20 VlcWGsNsdG 29
                ++++G N +G
  EFC36683.1 79 IYSCGKNKYG 88
                69******99 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 2.4e-06
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsd 28 
                 +k+v aG+yH  +Lte GeV+  G Ns+
  EFC36683.1 126 IKQVEAGAYHLAILTEFGEVYVSGYNSF 153
                 79************************96 PP

  == domain 3  score: 31.9 bits;  conditional E-value: 1.3e-11
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 Vk++s+G++H + Lt++Ge+++ G N++GQ
  EFC36683.1 176 VKAISSGWFHLMLLTNEGELYSSGLNTNGQ 205
                 89***************************9 PP

  == domain 4  score: 22.3 bits;  conditional E-value: 1.4e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 +k +++G  Hs ++t++G+++  G N++G
  EFC36683.1 246 IKRLCCGEHHSAFITNNGALYVAGKNNCG 274
                 67899***********************9 PP

  == domain 5  score: 23.4 bits;  conditional E-value: 6.1e-09
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++s+G +Hs+ L+ dG ++  GsN++GQ
  EFC36683.1 301 DISFGKDHSVLLSQDGQIYVSGSNESGQ 328
                 7**************************9 PP

  == domain 6  score: 13.2 bits;  conditional E-value: 1e-05
      RCC1_2   1 VksvsaGdyHscaLted.GeVlcWGsNsdG 29 
                 ++++s+G  Hs+a+t++ G + c G N +G
  EFC36683.1 352 ITKISCGFVHSMAITNTgGYMICSGGNING 381
                 689************98466***9999555 PP

  == domain 7  score: 6.9 bits;  conditional E-value: 0.00095
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 k+vs+G++ s++Lt+ +  +++G N+dG
  EFC36683.1 404 KHVSCGASLSVFLTDQN-AYSCGINTDG 430
                 679**********9999.9********9 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.0   8.6e-09   5.1e-05       4      49 ..      79     138 ..      77     139 .. 0.89
   2 ?    1.9   0.0      0.06   3.6e+02      35      49 ..     174     188 ..     162     189 .. 0.80
   3 !   19.8   0.2   1.5e-07    0.0009       1      50 []     192     259 ..     192     259 .. 0.77
   4 !   14.9   0.0   5.3e-06     0.032       1      50 []     262     312 ..     262     312 .. 0.84
   5 !   27.9   0.0   4.5e-10   2.7e-06       1      50 []     315     365 ..     315     365 .. 0.94
   6 !   12.3   0.0   3.4e-05       0.2       8      50 .]     376     416 ..     372     416 .. 0.89
   7 ?   -3.2   0.0       2.4   1.4e+04       5      14 ..     422     431 ..     420     431 .. 0.86
   8 ?   -3.7   0.2         3   1.8e+04      22      31 ..     904     917 ..     899     920 .. 0.62

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 8.6e-09
                 EEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS.............-EEEEEEETTEEEE CS
        RCC1   4 VysWGrndyGqLGlgtt.esvlvPtkveglsgn.............rvvkvacGddhtva 49 
                 +ys+G+n yG LG+ ++  +++vPt  + +++               +++v +G++h + 
  EFC36683.1  79 IYSCGKNKYGILGQLDDySEKPVPTVTPISKNSshhtienpsfapiMIKQVEAGAYHLAI 138
                 8*************99988889**8888877778899999999**************875 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.06
                 S-EEEEEEETTEEEE CS
        RCC1  35 nrvvkvacGddhtva 49 
                 ++v+++++G++h ++
  EFC36683.1 174 KKVKAISSGWFHLML 188
                 39**********887 PP

  == domain 3  score: 19.8 bits;  conditional E-value: 1.5e-07
                 TTEEEEEE--GGGTTSS........SS-..--EEEEEE-GGGTTS...........-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGl........gtt..esvlvPtkveglsgn...........rvvkvacGddhtval 50 
                 +G++ys G n++GqLGl        g++  ++v   ++ ++ +g+           +++  +cG +h++++
  EFC36683.1 192 EGELYSSGLNTNGQLGLeecsssgsGSSneDNV---VEHSLEDGKeeiiesyelniPIKRLCCGEHHSAFI 259
                 7****************9998887755564444...44444444466777778889************987 PP

  == domain 4  score: 14.9 bits;  conditional E-value: 5.3e-06
                 TTEEEEEE--GGGTTSSSS---EEEE.....EE-GGGTTS.-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvP.....tkveglsgn.rvvkvacGddhtval 50 
                 +G +y  G+n+ G LG+g + s+  P     t+v+       +++++ G dh+v+l
  EFC36683.1 262 NGALYVAGKNNCGELGIGRKSSK--PnvayfTLVQA---GfLAQDISFGKDHSVLL 312
                 699********************..97666666644...1389**********986 PP

  == domain 5  score: 27.9 bits;  conditional E-value: 4.5e-10
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS.-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgn.rvvkvacGddhtval 50 
                 dG++y  G+n+ Gq Glg+ +sv + +k+++ +   +++k++cG  h++a+
  EFC36683.1 315 DGQIYVSGSNESGQIGLGNVKSVKKFVKINMVRPGfKITKISCGFVHSMAI 365
                 9*******************9998889**9988779*************98 PP

  == domain 6  score: 12.3 bits;  conditional E-value: 3.4e-05
                 E--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   8 GrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtval 50 
                 G n +G LGl +++++  P+  ++ ++   ++v+cG++ +v+l
  EFC36683.1 376 GGNINGELGLSDRVKK--PQFAMLKTNLIPKHVSCGASLSVFL 416
                 8899************..*8887766559***********986 PP

  == domain 7  score: -3.2 bits;  conditional E-value: 2.4
                 EEEE--GGGT CS
        RCC1   5 ysWGrndyGq 14 
                 ys+G n++G+
  EFC36683.1 422 YSCGINTDGR 431
                 9***999996 PP

  == domain 8  score: -3.7 bits;  conditional E-value: 3
                 -E....EEEEE-GG CS
        RCC1  22 sv....lvPtkveg 31 
                 ++     vP+++++
  EFC36683.1 904 QQqyiyQVPSQIPP 917
                 33356678**9986 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.7     1e+04      21      47 ..     168     193 ..     165     212 .. 0.77
   2 !   22.9   2.1   1.3e-08   7.7e-05       2      80 ..     619     725 ..     618     751 .. 0.63
   3 ?   -0.8   0.0       0.3   1.8e+03      66     103 ..     728     766 ..     709     770 .. 0.61

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.7
                 EEEEE-HHHHHHH-HHHHHHHTSTTTT CS
         BTB  21 kefkahkavLaarSpyFkalftskeie 47 
                 ++++  k v a +S  F+ ++  + + 
  EFC36683.1 168 HKLHFDKKVKAISSGWFHLMLLTN-EG 193
                 678899999999999999999988.33 PP

  == domain 2  score: 22.9 bits;  conditional E-value: 1.3e-08
                 HHHHHHTTTS-EEEEETT..TEEEEE-HHHHHHH-HHHHHHHTST.TTTTCCCE..............EEEETTSGHHHHHHHHHHHHHSEEEC-.... CS
         BTB   2 nelresgelcDvtlvvgd..gkefkahkavLaarSpyFkalftsk.eieessvs..............eielddvepeafealLefiYtgeleit.... 79 
                 +++++ ++ +Dv + ++   ++ ++ hk +L+++Sp F+++f ++ ++++++++              e    +++ +a+  l++ +Y    + +    
  EFC36683.1 619 HNMFNDQATSDVKVIIDSekKHVLYLHKTILSSYSPLFEKIFDEQfQFSKDDNCldlydfdldsrnaiEASEAKIKEKALLHLMHACYGISKQQDsvdd 717
                 6778888999*999999888999**********************944444444333333333333334444555555666666666655444444555 PP

                 .......C CS
         BTB  80 .......s 80 
                        +
  EFC36683.1 718 sfvllnsE 725
                 55555533 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.3
                 HHHHHHHHSEEEC-.CGGGHHHHHHHHHHHT-HHHHHHH CS
         BTB  66 alLefiYtgeleit.seenleelLaaadllqiprlkkac 103
                 +l+ +iY + l    s  ++  + ++a ll +++  ++c
  EFC36683.1 728 ILIGMIYHASLFQMdSVIQIYLIRKLATLLSVENFLDIC 766
                 555566666665542222333333555666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1018  (0.0567795); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.89u 0.23s 00:00:01.12 Elapsed: 00:00:00.45
# Mc/sec: 7414.53
//
Query:       EFC36684.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-26   91.9   6.3    6.4e-26   91.3   6.3    1.2  1  G-alpha   G-protein alpha subunit
  ------ inclusion threshold ------
      0.073   12.5   0.1       0.43   10.0   0.0    2.3  2  Arf       ADP-ribosylation factor family
       0.27   10.0   0.0       0.43    9.4   0.0    1.2  1  DUF917    Protein of unknown function (DUF917)


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.3   6.3   1.1e-29   6.4e-26      25     291 ..      38     315 ..      10     325 .] 0.73

  Alignments for each domain:
  == domain 1  score: 91.3 bits;  conditional E-value: 1.1e-29
                 EEEEEESTTSSHHHHHHHHHHHCS--.--HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH..........HHC CS
     G-alpha  25 kllllGqseSGKsTilkqlkllykkg.fseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliaklssateeeqei 122
                    l G++ SGKsT++   k + +k+ f  + + ++   +q  +++ + ++  +le++e + ++ + l+  +  ld++ ++        +++  ++   
  EFC36684.1  38 GCSLFGTANSGKSTLYYLAKHILRKEwFYSS-KIEFEHDLQYACCSMMGKLWSILEESERKQMKGLILERFESTLDKIEEIIRI----KDWDLFDSFPQ 131
                 56799***************77766656666.345999999***************9766665544444444444444444333....22222333333 PP

                 CHHC-HCHHHHHHHHCCSHHHHHHHCCG.CCTT--TTHHHHHCT............HHHHCST.T----CHHHHCS-----SEEEEEEECT-TEEEE.. CS
     G-alpha 123 efnpraevgedikaLwndpgiqelyerr.nkiklednaeyFldd............leritsp.dYlptddDilkarlktvGisetkfevdsklefr.. 205
                 +   + +++e ++ +w+ p+++elye r n+i+l  n+  ++++            l+ +++  ++l + ++   + l+ + ++e++ + + + efr  
  EFC36684.1 132 VS--NFDFCELLIHVWKIPNMRELYEIRwNEISL--NISQYCNEhknsinlhsrlnLQMLENLpEFLENIENPNESFLPLTWCYECTNSSK-QFEFRyg 225
                 33..559999****************77699997..7888888778888887777655555545777777777777777777777777666.7777777 PP

                 .EEEE-SSHHHHHGTCCCT.TTECEEEEEEEGGGTT-B-SS-TT.SBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS.-G CS
     G-alpha 206 .ivdvgGqrserkkWvpff.ddvdaiiFlvslsefdqvlyedek.vnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg.kl 291
                  + dvgG+r+er++W++ + +  ++i+ ++slse+dq+l+ed++ + r++++ ++Fk + + ++l +t+ i++++K+Dil +Kl+kg  +
  EFC36684.1 226 yFRDVGGARTERRTWMQSLaSMPETIFLVISLSEIDQYLAEDDSqTLRIQDTKRMFKFMNSIPELMDTRKIVLFTKPDILIKKLQKGvTV 315
                 789*************98747778888899***********975499*************************************998644 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.36   2.2e+03      19      32 ..      41      54 ..      38      60 .. 0.80
   2 ?   10.0   0.0   7.2e-05      0.43      63     129 ..     228     306 ..     213     320 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.36
                EEESTTSSHHHHHH CS
         Arf 19 llGLDnaGKtTilk 32
                l G  n+GK+T+ +
  EFC36684.1 41 LFGTANSGKSTLYY 54
                568899*****976 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 7.2e-05
                 EEE-SSGGGGGGGGGGCTTESEEEEEE............ETT-CTTHHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTT CS
         Arf  63 wDvGGqeklRplWknYfektdavifvv............DsadreRleeakeeLkalleeeelkevallvlaNKqDlpe 129
                  DvGG ++ R+ W + ++++   if+v            D +++ R++++k+ +k + +  el +   +vl  K D+  
  EFC36684.1 228 RDVGGARTERRTWMQSLASMPETIFLVislseidqylaeDDSQTLRIQDTKRMFKFMNSIPELMDTRKIVLFTKPDILI 306
                 4*******************99999984444443333333344559999999999999999999988888888888755 PP

>> DUF917  Protein of unknown function (DUF917)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   7.2e-05      0.43       6      92 ..      35     117 ..      33     121 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 7.2e-05
                 HHHHHHHTTTT-SS-HHHHHHHHTT-SBTT--EEEE-GGG--SEE..EEEEEEE-HHHHTT-SS-HH....HHHHHHHHHT--EEEE CS
      DUF917   6 latGaavLGtGGGGspysgylllrqaleegksvrvvsldelpddalvvvvgamGsptvieeklpsgdelleavealekllgrkidav 92 
                 + +G++++Gt+  G+    y l++++l+++      s  e++ d  ++++++mG   +i e+  +++    ++e  e  l  ki+ +
  EFC36684.1  35 IGEGCSLFGTANSGKST-LYYLAKHILRKE--WFYSSKIEFEHDLQYACCSMMGKLWSILEESERKQMKGLILERFESTL-DKIEEI 117
                 779***********986.67789****955..45566669999999**********999999977777777777777766.555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       829  (0.0462379); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1954.76
//
Query:       EFC36685.1  [L=740]
Description: hypothetical protein NAEGRDRAFT_59952 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.2    9.1   8.7        6.3    6.7   1.5    2.7  2  DUF5102   Domain of unknown function (DUF5102)


Domain annotation for each model (and alignments):
>> DUF5102  Domain of unknown function (DUF5102)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   1.5   0.00035       6.3      16      80 ..      90     152 ..      72     184 .. 0.59
   2 ?    5.6   0.9   0.00076        14      30     112 ..     317     419 ..     293     423 .. 0.54

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00035
     DUF5102  16 ddddFgDFddgfqeeeaeeseeaeeeepaepsasslsfplldfesldlesdll.aaleeeldelfp 80 
                  dddFg +dd+ +  ++++s+++ +++ +++++++ +     + +l ++++l+  + ++el+++f 
  EFC36685.1  90 FDDDFGSWDDQSSATTENTSSDSIRKQAKQEEEKMKQ---EYLANLPMKDKLEeLENRPELKAIFQ 152
                 489******8544444222222222222222222222...23345555555554555677777774 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.00076
     DUF5102  30 eeaeeseeaeeeepaepsasslsfplldfesldlesdllaaleeeldelfppseeke...................irslev.plskesqifltersls 108
                 +++++  +++eee +e+ ++  +++   f++  + + ll++le++  ++f+++ + e                   +++ ++ +l+  ++i++t +++ 
  EFC36685.1 317 NSNSSFGNESEEENSEEMKTYKAVQEWTFSKYAMLDRLLNKLESYTTQVFDEDLNIEiedeqknifslltqlieksLTKRPSyTLPAIQSILSTTNIER 415
                 332222222222222222222333334555556666666666666666665555433444455555555555555555555347888899999999999 PP

     DUF5102 109 Lwsq 112
                 Lw  
  EFC36685.1 416 LWDI 419
                 9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (740 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1428  (0.0796475); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.29s 00:00:01.09 Elapsed: 00:00:00.51
# Mc/sec: 4395.80
//
Query:       EFC36686.1  [L=440]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (440 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1168  (0.0651459); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.47
# Mc/sec: 2819.81
//
Query:       EFC36687.1  [L=1596]
Description: hypothetical protein NAEGRDRAFT_82165 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      6e-08   32.8   1.8    1.1e-06   28.8   0.9    3.2  2  Myb_DNA-bind_6   Myb-like DNA-binding domain
     0.0001   22.4   0.1    0.00029   21.0   0.1    1.8  1  Myb_DNA-binding  Myb-like DNA-binding domain
  ------ inclusion threshold ------
        0.1   12.9   0.0       0.85   10.0   0.0    2.8  1  HEAT             HEAT repeat
       0.12   12.4   0.6        0.5   10.4   0.6    2.1  1  TPP1             Shelterin complex subunit, TPP1/ACD
        0.2   11.9   1.3       0.46   10.7   0.0    2.4  2  SANT_DAMP1_like  SANT/Myb-like domain of DAMP1
        2.4    8.5   6.3         24    5.3   0.0    4.3  3  ACDC             AP2-coincident C-terminal


Domain annotation for each model (and alignments):
>> Myb_DNA-bind_6  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.25   7.4e+02      19      43 ..     849     872 ..     831     884 .. 0.81
   2 !   28.8   0.9   3.6e-10   1.1e-06       1      54 [.    1514    1575 ..    1514    1580 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.25
  Myb_DNA-bind_6  19 dWknIaealnrRtpkqcfdrwknkL 43 
                     dW++  +++++ t++++++r +n L
      EFC36687.1 849 DWSELVSCIGKDTHSSVKQRICN-L 872
                     9********97889999998666.5 PP

  == domain 2  score: 28.8 bits;  conditional E-value: 3.6e-10
  Myb_DNA-bind_6    1 WteeEdeiLlklvekygndWknIaealn.....rRtpkqcfdrwknkLrpkisrkk...wsk 54  
                      W+e+E ++L +++++++++W++I + ++      Rtp +++d+++++L pk++r++   + +
      EFC36687.1 1514 WSEQEMDKLEEGYRRFSDNWTKILKVYSttfhtCRTPAALKDKFLRTLAPKFKREEeesYED 1575
                      ***********************5555445558********************987444444 PP

>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.1   9.7e-08   0.00029       4      44 ..    1514    1559 ..    1512    1561 .. 0.95

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 9.7e-08
                       SBHHHHHHHHHHHHHHTTCHHHHHHHHTS.....S-HHHHHHHHHH CS
  Myb_DNA-binding    4 WteeEdelLleavkkhGnrWkkIaerlgg.....Rtekqcrsrwrn 44  
                       W+e+E ++L+e+ +++ ++W+kI++ + +     Rt+ + ++++++
       EFC36687.1 1514 WSEQEMDKLEEGYRRFSDNWTKILKVYSTtfhtcRTPAALKDKFLR 1559
                       ***************************977999***********97 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   0.00029      0.85       1      28 [.     618     645 ..     618     648 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00029
                 HHHHHHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   1 llPlllkllsDpspeVReaAakaLgala 28 
                 +l+++l+  +D++++VR  A++ +++++
  EFC36687.1 618 FLNIVLQRTNDKDAFVRTRAFQKIADIS 645
                 58999*****************999986 PP

>> TPP1  Shelterin complex subunit, TPP1/ACD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.6   0.00017       0.5       3      83 ..    1375    1456 ..    1372    1460 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00017
                  HHHHHHHT--TTTS-.-HHHHT-..GGGEEEEEEEEE.EETTEEEEEEE-SS-EEEEEE-HHHHHHHHHHHSS-TTSS-TTS CS
        TPP1    3 Ieklvleaiklssdl.spslntnkskaqllkvlkfaqdtsnsaitavlsDsthkIlaiftreavenfereekeritsetkgc 83  
                  I+++++++++ +s + s++ +++k++ +  k+ + + +++++ i   lsD   k + +f ++++ +  +++++   + t+++
  EFC36687.1 1375 ILQSIHNQEDTQSTTsSTQSKNGKKRLRQTKLFDLTPNKDKQRISTGLSDDNAKMKQEFEPDCTLQGLNKYRKTSEYYTENK 1456
                  4556666666666646555667777777888888888**********************************99999999986 PP

>> SANT_DAMP1_like  SANT/Myb-like domain of DAMP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.2       4.4   1.3e+04      14      26 ..    1451    1463 ..    1443    1467 .. 0.76
   2 ?   10.7   0.0   0.00016      0.46      28      73 ..    1510    1558 ..    1486    1562 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.4
  SANT_DAMP1_like   14 eytdeeYeellke 26  
                        yt+++Y++++++
       EFC36687.1 1451 YYTENKYTNFITD 1463
                       6999999999876 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00016
  SANT_DAMP1_like   28 d...WtkeetdyLfdlckeydlrfvviaDryelekkkkrsledlkeryY 73  
                       +   W+++e+d+L + ++++   ++ i   y+++ ++ r+   lk+++ 
       EFC36687.1 1510 SsrfWSEQEMDKLEEGYRRFSDNWTKILKVYSTTFHTCRTPAALKDKFL 1558
                       1345*****************************99999**999999996 PP

>> ACDC  AP2-coincident C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.5      0.69   2.1e+03      57      57 ..     562     562 ..     448     618 .. 0.67
   2 ?    3.0   0.3     0.043   1.3e+02      20      74 ..     955    1006 ..     942    1007 .. 0.91
   3 ?    5.3   0.0    0.0082        24      48      81 ..    1120    1153 ..    1100    1159 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.69
        ACDC  57 k 57 
                 +
  EFC36687.1 562 S 562
                 1 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.043
        ACDC   20 nnclpqlasslanktsskelkrvieahikyvenakslkelqpylklFstcilknk 74  
                  +n+l +l+  + n+   +  +++i+  i+++e+++ ++  qp+ k  ++++++n+
  EFC36687.1  955 ENILQNLKDLISNI---EGNRKLISLKIRIIEEVYRISNNQPFKKSVDNFLEENI 1006
                  68888888888888...89999****************************99986 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.0082
        ACDC   48 kyvenakslkelqpylklFstcilknklPSqlsl 81  
                  ++v+++    +l  y++l+++c + +k P +l+ 
  EFC36687.1 1120 RAVTESLTKGFLSRYVNLLRNCMQSRKAPKSLKS 1153
                  6789999999*******************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1596 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1216  (0.0678231); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.97u 0.32s 00:00:01.29 Elapsed: 00:00:00.51
# Mc/sec: 9413.20
//
Query:       EFC36688.1  [L=597]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-22   79.0   3.1    1.6e-16   60.3   0.5    2.4  2  Rad10     Binding domain of DNA repair protein Ercc1 (rad10/S
    4.2e-05   24.1   0.0    8.2e-05   23.1   0.0    1.4  1  HHH_5     Helix-hairpin-helix domain
  ------ inclusion threshold ------
      0.014   15.5   0.0      0.095   12.8   0.0    2.1  2  HHH_2     Helix-hairpin-helix motif
        1.4    9.1  10.4        5.2    7.2  10.4    2.1  1  MRP-L20   Mitochondrial ribosomal protein subunit L20


Domain annotation for each model (and alignments):
>> Rad10  Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.3   0.5   3.6e-20   1.6e-16       1      77 [.     229     316 ..     229     327 .. 0.89
   2 !   18.8   0.1   2.8e-07    0.0013      79     113 ..     352     386 ..     345     387 .. 0.90

  Alignments for each domain:
  == domain 1  score: 60.3 bits;  conditional E-value: 3.6e-20
       Rad10   1 tilvserqkgnplLkslk.nvp.wey.kd.ivpDyvigsttcvlflslkyhklhpeYieerlkklkkk.......yklrvlLvlvDve 77 
                 ti+ +e qk+np++k+++ +v  +++ kd +++Dy++g++t +++lslk+h ++p+Yi er+k+++k+       +++r++Lv vDv+
  EFC36688.1 229 TIVANEVQKKNPIVKHIRdKVFkLHFtKDwTLTDYILGRQTTAFYLSLKFHMTKPKYILERIKNFHKTeickrgtFTNRIILVNVDVH 316
                 5899**************533237776557889*********************************667999999***********96 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 2.8e-07
       Rad10  79 seevlkeLnkicilndltlllawsaeeaaryletl 113
                  +e+l e+++i++ +d+t+++++s ee+a ylet+
  EFC36688.1 352 LDEALIEVTRISMWADWTVICGFSDEECALYLETI 386
                 578999***************************96 PP

>> HHH_5  Helix-hairpin-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.0   1.8e-08   8.2e-05      13      52 ..     469     507 ..     464     510 .. 0.91

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.8e-08
                 HHHHHHHTTT--SHHHHHHS-HHHHHTSTTS-HHHHHHHH CS
       HHH_5  13 ktAlallsaGiesvedlaaadveeLakipGiGkktAerii 52 
                 ++ ++ll++ ++s+ ++++ + +eL ++pG+Gkk+++++i
  EFC36688.1 469 RDHITLLNH-FGSLKEVIQTTSDELNDLPGFGKKKVKKLI 507
                 556789***.****************************99 PP

>> HHH_2  Helix-hairpin-helix motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0       0.1   4.7e+02      33      63 ..     444     474 ..     441     475 .. 0.90
   2 ?   12.8   0.0   2.1e-05     0.095      18      58 ..     473     513 ..     472     515 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.1
       HHH_2  33 sleeLlevddiGeeiAqsivefFeneknrel 63 
                 ++e+L++ +++ +  A+  ++ +++ ++++l
  EFC36688.1 444 EVEKLSHTEEVHQLFAATLKNTLNKRDHITL 474
                 689********************99999876 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 2.1e-05
       HHH_2  18 lLakrFksldaLkkasleeLlevddiGeeiAqsivefFene 58 
                 +L ++F+sl +  +++ +eL  +++ G++  ++ ++ F+++
  EFC36688.1 473 TLLNHFGSLKEVIQTTSDELNDLPGFGKKKVKKLINLFQTP 513
                 599*************************9999999999876 PP

>> MRP-L20  Mitochondrial ribosomal protein subunit L20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2  10.4    0.0012       5.2      18      67 ..      82     152 ..      64     207 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0012
     MRP-L20  18 nlkpeesfg...........liynPpssapsvsh...tPtkFLPksdprrellaakeskassk.......s 67 
                 +  + ++++            ++ Pp+s+ps s+    P kF+P++ + ++ +++++s++s++       s
  EFC36688.1  82 SSSNTPTTNytsriinrtpgTVVSPPNSIPSNSNvpfVPQKFIPPQRISQTSQNSQNSQKSNSspsvgsgS 152
                 222222222445666777779*************9999*******99997665555555544344444441 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (597 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1372  (0.0765241); expected 358.6 (0.02)
Passed bias filter:                      437  (0.0243739); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 3679.83
//
Query:       EFC36689.1  [L=1186]
Description: ankyrin repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.8e-11   42.2   0.4     0.0008   19.7   0.1    3.2  2  BTB_2         BTB/POZ domain
  ------ inclusion threshold ------
      0.072   13.4   1.3       0.34   11.2   0.1    2.9  2  NTP_transf_2  Nucleotidyltransferase domain
       0.16   12.1   0.1       0.16   12.1   0.1    2.7  3  Polbeta       Polymerase beta, Nucleotidyltransferase


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0     2e-07    0.0012       1      85 [.     119     210 ..     119     217 .. 0.72
   2 !   19.7   0.1   1.3e-07    0.0008       1      88 [.     310     391 ..     310     395 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 2e-07
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE.-S-HHHHHHHHHHHHS...S......-B---TTS-HHHHHHHHHHHT CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyff.DRspklFetiLnyyrtg..g......kLhrpeevelkslleElefyg 85 
                 vkl VgG+ f ts st++ + + +++++l+ +  +  ++e++++++ + +p++F  iL+ +rtg         ++ + + ++lk+ll E +++g
  EFC36689.1 119 VKLMVGGKMFVTSLSTIN-RRENMIKTMLNSD-FKVDRDENGCILLsESNPDYFPIILEHIRTGstTyvglweNITEDTIEKLKALLIESDYFG 210
                 7899**************.6778999999977.889999999998836789************7421111222234444455555666666665 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 1.3e-07
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS...S-B---TTS-HHHHHHHHHHHT--T CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtg..gkLhrpeevelkslleElefyglee 88 
                 ++ nV G++f +  + L   p++++ +l ++       ++++e+f+DR++++F+++ +y+++     ++r+   + k + +E++ ++l+ 
  EFC36689.1 310 IVFNVRGVKFCIGIEKLLVHPESIFPQLIQA-------STNREIFLDRDSEVFSVLYEYLESAtfTSVPRE-MSQRKLVYKEAKEFKLQG 391
                 568***************************4.......47789******************9844444443.444455678888888776 PP

>> NTP_transf_2  Nucleotidyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.2       1.1   6.3e+03      65      89 ..      58      87 ..      36     113 .. 0.54
   2 ?   11.2   0.1   5.6e-05      0.34      26      48 ..     627     667 ..     624     725 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.1
                  ECTTEEEEEE.....CEEECCCCTEEEEEE CS
  NTP_transf_2 65 ellglevdlv.....trekledpllvksil 89
                  el  +++d +     +r   +++++ +++l
    EFC36689.1 58 ELETVRIDALhkideERRRNQQKMKEIEVL 87
                  444444444422222222222233333333 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 5.6e-05
                   TTSCTTSSEEEEEEESTTCHHH..................H CS
  NTP_transf_2  26 GtalkgSDiDllvvlpeevsre..................k 48 
                     + k+SDiDl++++ +e++ e                   
    EFC36689.1 627 KSYWKNSDIDLFIYGLDEKEAEkkifylfelfkkniknipH 667
                   56779*************77778777755444333333330 PP

>> Polbeta  Polymerase beta, Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.53   3.2e+03       1      15 [.     106     120 ..      69     125 .. 0.62
   2 ?   12.1   0.1   2.6e-05      0.16      23      57 ..     625     659 ..     623     686 .. 0.80
   3 ?   -3.1   0.3       1.4   8.5e+03      24      44 ..    1139    1160 ..    1137    1171 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.53
                 -STTTTHHHHHHHHS CS
     Polbeta   1 ekikeilekekeiel 15 
                 ek+keil++ ++i  
  EFC36689.1 106 EKVKEILQSGENIVK 120
                 455555555555555 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 2.6e-05
                 E-S------EEEEEEEESS---HHHHHHHHHHHHH CS
     Polbeta  23 akgkareeSDiDlavllkekldleeelelaaeled 57 
                  ++ ++++SDiDl+++  ++++ e+++ +  el +
  EFC36689.1 625 FRKSYWKNSDIDLFIYGLDEKEAEKKIFYLFELFK 659
                 578899*************9888887776666544 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.4
                  -S------EEEEEEEESS-.-- CS
     Polbeta   24 kgkareeSDiDlavllkek.ld 44  
                  k+   eeSD D+ + +k+k ++
  EFC36689.1 1139 KKYDSEESDDDMKYETKKKiES 1160
                  5666789999999988888522 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1943  (0.108372); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.97u 0.32s 00:00:01.29 Elapsed: 00:00:00.52
# Mc/sec: 6925.80
//
Query:       EFC36690.1  [L=1015]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.6e-07   29.0   5.1    9.7e-06   25.6   1.6    2.0  2  DUF3421      Protein of unknown function (DUF3421)
     0.0019   18.4   4.1     0.0086   16.4   0.6    3.7  4  RNA_binding  RNA binding
  ------ inclusion threshold ------
        1.8    8.4   7.2       0.11   12.3   0.3    2.5  3  SLS          Mitochondrial inner-membrane-bound regulator


Domain annotation for each model (and alignments):
>> DUF3421  Protein of unknown function (DUF3421)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.1   6.7e-06      0.04      62     113 ..     887     937 ..     885     940 .. 0.90
   2 !   25.6   1.6   1.6e-09   9.7e-06       6     112 ..     905    1003 ..     899    1006 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 6.7e-06
                 TT---......TTB-EETTEEEEEEEETTEEEEEEEETTTTEEEEEETTEEE CS
     DUF3421  62 dgqvpkgAvegGrsedgepLyigrakvegslvpGkvhpshkvayipyggkEv 113
                  g vp++A++g +++    +y++ a+ + + +pGk   s ++a +pygg+E 
  EFC36690.1 887 SGMVPHNAITGFQNDGAGVVYVAVAHSQWGNIPGKANAS-GTAWFPYGGQEQ 937
                 689******9999999999****************9765.899*******95 PP

  == domain 2  score: 25.6 bits;  conditional E-value: 1.6e-09
                  EEEEEEEEETTEEEEEEE-TTSSSEEEEETTEEEEESEEEEEETTSB-EEEEEEEETT---......TTB-EET.TEEEEEEEETTEEEEEEEETTT CS
     DUF3421    6 piYvgRakhegsvlpgkvvpekkaayvsyggkehekseyevLvakdpseleWvpssdgqvpkgAvegGrsedge.pLyigrakvegslvpGkvhpsh 101 
                   +Yv+ a+ +   +pgk+ ++  +a+ +ygg+e   +++   v+       + +   g+ p+++v +G+++dg   L+ + a+++ + +pGk +   
  EFC36690.1  905 VVYVAVAHSQWGNIPGKANASG-TAWFPYGGQEQVTNNFSYVVN----GTTYKH--SGDSPAQSVATGYQNDGAgTLWSAIAHTSHGDIPGKAKG-- 992 
                  58****************9998.9*******************4....344444..488999*********996379999************875.. PP

                  TEEEEEETTEE CS
     DUF3421  102 kvayipyggkE 112 
                  +++  pyggkE
  EFC36690.1  993 NTCWYPYGGKE 1003
                  68999****99 PP

>> RNA_binding  RNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.2   7.4e+03      45      84 ..     112     135 ..     102     153 .. 0.55
   2 ?   -1.7   0.1      0.55   3.3e+03      53      89 ..     276     312 ..     268     321 .. 0.62
   3 !   16.4   0.6   1.4e-06    0.0086       9     111 ..     591     711 ..     589     720 .. 0.71
   4 ?   -1.0   0.0      0.35   2.1e+03      38      69 ..     837     868 ..     830     877 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.2
                  EEEEEEEESSHHHHHHHHHHHHHHCCCCHHHHHHCCHCCB CS
  RNA_binding  45 itileaelekkkakkvlkkllellreeeikeLlkeleerv 84 
                  it l+                  +r++e++ +++ +e+ v
   EFC36690.1 112 ITSLSS----------------TIRKNEFESVRSYIEKTV 135
                  444444................444444444444444332 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.55
                  SSHHHHHHHHHHHHHHCCCCHHHHHHCCHCCB-TTSE CS
  RNA_binding  53 ekkkakkvlkkllellreeeikeLlkeleervdekgk 89 
                  ++++  ++ k+l+ +++ ++i+++l++l + + ++  
   EFC36690.1 276 KSNSTTEISKYLAFSMELKRISKFLEDLVSSIARSTA 312
                  5555566677777777777777776666666554444 PP

  == domain 3  score: 16.4 bits;  conditional E-value: 1.4e-06
                  -TTC-HHHHHHHHHTTSTTSE---.EEEEEE-CCC-EEEEEEEEESSHHHHHHHHHHHHHHCCCCH.................HHHHHCCHCCB-TTS CS
  RNA_binding   9 haTEdeekVlealsnllpeeevei.eeeeaeGhygnpitileaelekkkakkvlkkllellreeei.................keLlkeleervdekg 88 
                  ++TEd++ V + ls + ++++v+  ++    G ++n+i+il+++++k ++++v k l      +e+                 ++ +++++ ++ e+ 
   EFC36690.1 591 YKTEDCKSVVNLLSLVYEQINVQSrSSGFNIGAFENDIIILSFNTTKDSQNHVEKALSTVKVLQEKllavrknlvsnsfsshsSKKSEKVSHQLAENL 688
                  89***************98854441333456****************777666666654333333346777788888887777555556666666678 PP

                  EEEEEEEHHHHHTT---BESSSS CS
  RNA_binding  89 klylrldKQaaylgklslvegdd 111
                  ++ + +  Q++y g+l  +e+++
   EFC36690.1 689 QFRFAITTQRVYCGNLGTSESKN 711
                  88888888888888888777766 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.35
                  E-CCC-EEEEEEEEESSHHHHHHHHHHHHHHC CS
  RNA_binding  38 eGhygnpitileaelekkkakkvlkkllellr 69 
                  + hy+n  +++e  + ++++k+++++l+++ +
   EFC36690.1 837 SEHYENALKLFEEFMAESSNKETAESLKDSAN 868
                  56999999999999999888999999888765 PP

>> SLS  Mitochondrial inner-membrane-bound regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.3   1.9e-05      0.11     112     192 ..     297     376 ..     270     401 .. 0.66
   2 ?   -1.9   0.3      0.41   2.5e+03     135     179 ..     638     680 ..     594     703 .. 0.63
   3 ?   -2.9   1.2      0.83   4.9e+03      80      80 ..     718     718 ..     640     824 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.9e-05
         SLS 112 dllseelleelgrltntvievseddn.nknskselkisalgedradlakRlLlwalgpsdsnkrlseallavtssskskn.tt 192
                 +++ e+l ++++r t   ie +++d     ++  +++++l e+++d+++R+ l++l  s+++++l ++++ + ++ k+ +  t
  EFC36690.1 297 SKFLEDLVSSIARSTAFIIE-TKTDYlIAVNNRTISLAYLAENKVDVIRRTGLTVL--SEEHNKLAKEMYRNYPNLKELKcDT 376
                 225788999***********.66666867788999*********************..3355666666655555544444343 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.41
         SLS 135 ddnnknskselkisalgedradlakRlLlwalgpsdsnkrlseal 179
                 d++n+ +k   ++  l+e+   + k l  +++++++  ++ se++
  EFC36690.1 638 DSQNHVEKALSTVKVLQEKLLAVRKNLVSNSFSSHS--SKKSEKV 680
                 333445566666666666666666666677773333..3333333 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 0.83
         SLS  80 i 80 
                 +
  EFC36690.1 718 A 718
                 2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1015 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1301  (0.072564); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.86u 0.31s 00:00:01.17 Elapsed: 00:00:00.53
# Mc/sec: 5754.18
//
Query:       EFC36691.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00024   21.3   0.4     0.0012   19.1   0.3    1.9  2  DUF3580   Protein of unknown function (DUF3580)


Domain annotation for each model (and alignments):
>> DUF3580  Protein of unknown function (DUF3580)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.3   6.5e-08    0.0012      25     110 ..      49     133 ..      24     143 .. 0.81
   2 ?    0.0   0.0     0.053   9.6e+02      96     119 ..     181     204 ..     171     205 .] 0.83

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 6.5e-08
     DUF3580  25 lgsarspfttpkstplsqn.yaltplasdledlalepwstpntpvagtaetqntgeagskacqdgqlsptwse.ieedlracfgaepl 110
                 lg   s f+  k   ls    +++p++sdl ++     s  n   a   ++     +gsk  +dg+ s tw e i     ++f   p 
  EFC36691.1  49 LG---SSFSKSKDISLSGSgNSFSPVSSDLYNIISSNHSENNHTSASPLNSYTFPSSGSKDSKDGEDSSTWVEtISSVCDSVFSVSPD 133
                 44...568888999998642689************************************************98344444566666665 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.053
     DUF3580  96 eieedlracfgaeplkkdfsepln 119
                   e d+r    + p+++df + +n
  EFC36691.1 181 SNERDIRIRSKSAPMQRDFQKRMN 204
                 5688999999999*****998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       616  (0.0343577); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1266.78
//
Query:       EFC36692.1  [L=1055]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   4.3e-162  525.8  76.2    2.6e-15   55.9   0.2   23.9 27  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.13   12.3   2.5       0.82    9.8   0.3    3.4  3  ENT       ENT domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.0   2.4e-10   2.2e-06       6      45 ..      84     123 ..      80     123 .. 0.97
   2 !   31.6   0.2   1.1e-11   9.8e-08       1      35 [.     104     138 ..     104     155 .. 0.83
   3 !   52.6   0.2     3e-18   2.7e-14       1      49 []     159     207 ..     159     207 .. 0.97
   4 !   26.9   0.0   3.3e-10     3e-06       1      49 []     208     258 ..     208     258 .. 0.93
   5 !   41.6   0.0   8.6e-15   7.7e-11       1      46 [.     260     304 ..     260     307 .. 0.96
   6 !   24.6   0.0   1.7e-09   1.6e-05       1      45 [.     285     328 ..     285     332 .. 0.95
   7 !   17.0   0.0     4e-07    0.0036       1      35 [.     309     342 ..     309     352 .. 0.89
   8 !   14.7   1.9   2.1e-06     0.019       1      48 [.     333     386 ..     333     387 .. 0.77
   9 !   16.7   0.5   5.1e-07    0.0045       6      49 .]     395     439 ..     394     439 .. 0.94
  10 !   33.4   0.1     3e-12   2.7e-08      15      49 .]     430     464 ..     428     464 .. 0.96
  11 !   37.0   0.0   2.3e-13   2.1e-09       1      49 []     466     514 ..     466     514 .. 0.98
  12 !   17.9   0.0   2.2e-07    0.0019       1      39 [.     516     555 ..     516     564 .. 0.86
  13 !   35.2   0.1   8.1e-13   7.3e-09       1      37 [.     566     601 ..     566     611 .. 0.93
  14 !   21.0   0.7   2.3e-08    0.0002       1      37 [.     614     650 ..     614     667 .. 0.80
  15 !   20.1   0.1   4.3e-08   0.00038      15      48 ..     658     691 ..     652     692 .. 0.92
  16 !   47.2   0.0   1.4e-16   1.3e-12       3      49 .]     671     717 ..     669     717 .. 0.97
  17 !   55.9   0.2   2.9e-19   2.6e-15       1      49 []     694     742 ..     694     742 .. 0.98
  18 !   27.2   0.2   2.5e-10   2.3e-06       1      31 [.     719     749 ..     719     753 .. 0.95
  19 !   19.8   0.7   5.4e-08   0.00048       3      49 .]     769     813 ..     758     813 .. 0.84
  20 !   19.6   0.3   6.2e-08   0.00056       1      32 [.     790     821 ..     790     822 .. 0.97
  21 !   15.3   0.2   1.4e-06     0.012      14      49 .]     827     862 ..     815     862 .. 0.83
  22 !   41.1   0.3   1.2e-14     1e-10       1      49 []     839     891 ..     839     891 .. 0.93
  23 !   31.9   0.0     9e-12     8e-08       1      44 [.     893     936 ..     893     941 .. 0.94
  24 !   27.6   0.0     2e-10   1.8e-06       1      44 [.     918     963 ..     918     964 .. 0.88
  25 !   30.6   0.0   2.3e-11   2.1e-07       1      48 [.     943     992 ..     943     993 .. 0.91
  26 !   16.0   0.5   7.9e-07    0.0071       1      38 [.     995    1032 ..     995    1042 .. 0.89
  27 ?    0.0   0.1      0.08   7.2e+02       7      29 ..    1025    1047 ..    1024    1047 .. 0.85

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 2.4e-10
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 l++v+ +g +l+++s++LknD  +vl+A+k n +a+++as
  EFC36692.1  84 LKIVRADGRVLEHASDDLKNDELVVLAAIKENVSAIEFAS 123
                 99************************************98 PP

  == domain 2  score: 31.6 bits;  conditional E-value: 1.1e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 D+ +vl a+k n sa++++s +Lk Dk++vlkA+k
  EFC36692.1 104 DELVVLAAIKENVSAIEFASQRLKTDKNFVLKALK 138
                 899*******************************9 PP

  == domain 3  score: 52.6 bits;  conditional E-value: 3e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D Ei+  av++ +++l+y+s +Lkn+++++lkA+k++g++l+y++++L+
  EFC36692.1 159 DDEIARLAVEQQPKCLQYVSANLKNNRDVILKAIKKDGSVLEYVPDNLK 207
                 569*******************************************997 PP

  == domain 4  score: 26.9 bits;  conditional E-value: 3.3e-10
     DUF4116   1 DrEivleavk..kngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivl   k  ++ + l+++++e++ Dkeivl A ++ g+ + ya e+Lr
  EFC36692.1 208 DREIVLLSTKssRYTCTLRFAPKEFTADKEIVLSAANSPGFYFLYAAESLR 258
                 9*******6644889*******************************99998 PP

  == domain 5  score: 41.6 bits;  conditional E-value: 8.6e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 Dr++vle+vkk g +l+ +s+ +k+D+eiv  Avk +g al ya++
  EFC36692.1 260 DRDFVLEIVKKKGDSLRDVSPQFKKDREIVYDAVK-SGRALQYADP 304
                 9**********************************.*******987 PP

  == domain 6  score: 24.6 bits;  conditional E-value: 1.7e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 DrEiv  avk+ g al+y+++ + +D+ei+  Av ++ ++ls + 
  EFC36692.1 285 DREIVYDAVKS-GRALQYADPIFWKDREIATLAVSKDAHSLSSLT 328
                 9**********.****************************99876 PP

  == domain 7  score: 17.0 bits;  conditional E-value: 4e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 DrEi++ av+k+  +l  l  +Lk D+e++l ++ 
  EFC36692.1 309 DREIATLAVSKDAHSLSSLT-DLKEDREFILNCIS 342
                 9*******************.9***********97 PP

  == domain 8  score: 14.7 bits;  conditional E-value: 2.1e-06
     DUF4116   1 DrEivleavkkngs...alkylseeLknDkeivlkAvk...qngtalsyaseeL 48 
                 DrE++l++++  ++    l y++++L nD +++ + +    ++++a+ y  e++
  EFC36692.1 333 DREFILNCISGANNfftFLDYVNSSLANDNDFIDELLDiqcKYSNAMWYSKEDF 386
                 9*********5555367788899*************985333446777777666 PP

  == domain 9  score: 16.7 bits;  conditional E-value: 5.1e-07
     DUF4116   6 leavkkngsalkyls.eeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + +v +++ +++++s +eLk D++++l ++ +  ++l+ + ee+r
  EFC36692.1 395 KRIVNIDPACFENIShDELKTDRQLILDCILSERKVLENLNEEFR 439
                 578999********8899************************998 PP

  == domain 10  score: 33.4 bits;  conditional E-value: 3e-12
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +l++l+ee++nD+e++  Avkq+  al+yas+eL+
  EFC36692.1 430 VLENLNEEFRNDRELIRLAVKQHYGALEYASDELK 464
                 6999*****************************97 PP

  == domain 11  score: 37.0 bits;  conditional E-value: 2.3e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vlea+  ++ +++++s+eL+ D ei+   + +++t+l+ya+e+ r
  EFC36692.1 466 DRELVLEAILFDSTNFTFASKELRMDTEILECTIIKDSTFLEYAPESVR 514
                 9*********************************************976 PP

  == domain 12  score: 17.9 bits;  conditional E-value: 2.2e-07
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngt 39 
                 DrE+vl a+++  + + +y+  +Lk D++++l+  k+ g+
  EFC36692.1 516 DREFVLRAIRNSfNTISQYFGYNLKEDRDLILEHAKRTGS 555
                 9*********873559999*************98888876 PP

  == domain 13  score: 35.2 bits;  conditional E-value: 8.1e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 DrEivl a++ +gs +ky+s +L nD+e+++ A++ n
  EFC36692.1 566 DREIVLTAIQLYGSEFKYASRSLLNDRELLIIALR-N 601
                 9*********************************9.4 PP

  == domain 14  score: 21.0 bits;  conditional E-value: 2.3e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 DrEiv e ++ + ++lk+++e ++ D eiv +A+   
  EFC36692.1 614 DREIVYESCRYDRNNLKNVPEQYRDDEEIVEAAISYT 650
                 9*********************************954 PP

  == domain 15  score: 20.1 bits;  conditional E-value: 4.3e-08
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                  ++ +s++Lk++ +++ k  k++g+++ y++e+L
  EFC36692.1 658 FFECVSDRLKSNVDFMRKMAKIYGYVIHYVPESL 691
                 57889***************************98 PP

  == domain 16  score: 47.2 bits;  conditional E-value: 1.4e-16
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +++ +  k++g++++y++e+L nD+e++l Av q+ + l yaseeL+
  EFC36692.1 671 DFMRKMAKIYGYVIHYVPESLANDRELILNAVSQDASTLQYASEELK 717
                 89*******************************************97 PP

  == domain 17  score: 55.9 bits;  conditional E-value: 2.9e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE++l+av+++ s l+y+seeLknDke++l A+k++  ++ ++see++
  EFC36692.1 694 DRELILNAVSQDASTLQYASEELKNDKEVILTALKISAECYQHISEEMK 742
                 9**********************************************86 PP

  == domain 18  score: 27.2 bits;  conditional E-value: 2.5e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivl 31 
                 D+E++l a+k+  ++++++see+knD e++ 
  EFC36692.1 719 DKEVILTALKISAECYQHISEEMKNDEEVLE 749
                 9***************************976 PP

  == domain 19  score: 19.8 bits;  conditional E-value: 5.4e-08
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 E ++ a++    +l+ l+ ++knD++++l Av+ n ++l y+s+ L+
  EFC36692.1 769 EAAMIALRL--RSLNDLDYSFKNDRQFALMAVNVNMNNLLYVSNRLK 813
                 455555555..47899999************************9986 PP

  == domain 20  score: 19.6 bits;  conditional E-value: 6.2e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 Dr+++l av  n ++l y+s++Lk D++++l+
  EFC36692.1 790 DRQFALMAVNVNMNNLLYVSNRLKMDRNFILE 821
                 9*****************************98 PP

  == domain 21  score: 15.3 bits;  conditional E-value: 1.4e-06
     DUF4116  14 salkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + + +++ +L+ D+ei+l+ ++ +g+++ ++s eL+
  EFC36692.1 827 YDILNVPIRLREDREIALRSLELSGDSIMHLSAELK 862
                 557799**************************9996 PP

  == domain 22  score: 41.1 bits;  conditional E-value: 1.2e-14
     DUF4116   1 DrEivleavkkngsalkyls....eeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEi+l  ++  g ++ +ls    +e+kn++ei+lkA+k++  a+ yaseeL+
  EFC36692.1 839 DREIALRSLELSGDSIMHLSaelkNEFKNNREIMLKAIKSDAVAFLYASEELQ 891
                 9*****************99555566788**********************97 PP

  == domain 23  score: 31.9 bits;  conditional E-value: 9e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 D+E+vle+ + ng++l+y++ ++ +++++vlk+ +++ + l +a
  EFC36692.1 893 DEEFVLECASVNGKVLQYVPLKFIHNRNVVLKCAQNHQDTLQFA 936
                 9************************************9999998 PP

  == domain 24  score: 27.6 bits;  conditional E-value: 2e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk..qngtalsya 44 
                 +r +vl++ +++   l+++ +e+ nDkeiv+ Av    + +al+ya
  EFC36692.1 918 NRNVVLKCAQNHQDTLQFAVPEFLNDKEIVMHAVSheTSYSALCYA 963
                 799*******************************954455677765 PP

  == domain 25  score: 30.6 bits;  conditional E-value: 2.3e-11
     DUF4116   1 DrEivleavk..kngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D+Eiv++av+  +  sal y+  e++nD++ivl+A++ + tal+ as e+
  EFC36692.1 943 DKEIVMHAVSheTSYSALCYALFEMRNDRDIVLRAIQHDVTALEVASYEI 992
                 9*********444478****************************999775 PP

  == domain 26  score: 16.0 bits;  conditional E-value: 7.9e-07
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38  
                  D++++ +a+++n ++l+++  +L+ + e++++  k+n 
  EFC36692.1  995 DEDFIAQAMDINIESLRFAHYSLRYNTEFLKRMNKNNR 1032
                  9*****************************99888765 PP

  == domain 27  score: 0.0 bits;  conditional E-value: 0.08
     DUF4116    7 eavkkngsalkylseeLknDkei 29  
                  + + kn+ + +++s++Lk+ +++
  EFC36692.1 1025 KRMNKNNRIVENASKKLKKTIDF 1047
                  56789999999*******99987 PP

>> ENT  ENT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       0.7   6.2e+03      16      37 ..     116     138 ..     111     165 .. 0.83
   2 ?   -0.5   0.0      0.15   1.3e+03      20      52 ..     582     615 ..     579     620 .. 0.79
   3 ?    9.8   0.3   9.2e-05      0.82      17      66 ..     707     754 ..     695     758 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.7
         ENT  16 lsAfraqgd.LseekkkllteLr 37 
                 +sA    ++ L  +k+ +l+ L+
  EFC36692.1 116 VSAIEFASQrLKTDKNFVLKALK 138
                 78888888889999999999887 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.15
         ENT  20 raqgd.LseekkkllteLrkeLsIsterHraelr 52 
                 +  +  L ++++ l+  Lr+ ++ s+ +  ++ r
  EFC36692.1 582 KYASRsLLNDRELLIIALRNGFRLSDYNEIELDR 615
                 55566699**************999977766655 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 9.2e-05
         ENT  17 sAfraqgd.LseekkkllteLrkeLsIsterHraelrrvksDerl.ktiret 66 
                 s+++  ++ L ++k+ +lt     L+Is e ++ + + +k+De++ +++r++
  EFC36692.1 707 STLQYASEeLKNDKEVILTA----LKISAECYQHISEEMKNDEEVlEALRKW 754
                 56666677799*******96....57****************9862567776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1055 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1009  (0.0562775); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.86u 0.35s 00:00:01.21 Elapsed: 00:00:00.54
# Mc/sec: 5858.87
//
Query:       EFC36693.1  [L=242]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.4e-05   22.1   0.6    9.6e-05   21.7   0.6    1.3  1  G-alpha         G-protein alpha subunit
      0.002   17.6   0.1     0.0035   16.8   0.1    1.3  1  Chordopox_G2    Chordopoxvirus protein G2
     0.0026   17.5   0.1     0.0046   16.7   0.1    1.4  1  ERK-JNK_inhib   ERK and JNK pathways, inhibitor
     0.0041   17.5   0.0     0.0054   17.1   0.0    1.6  1  AAA_16          AAA ATPase domain
  ------ inclusion threshold ------
      0.014   15.8   0.0      0.032   14.7   0.0    1.6  1  AAA             ATPase family associated with various cellula
      0.017   15.0   0.0      0.034   14.1   0.0    1.5  1  NACHT           NACHT domain
      0.028   14.1   0.0       0.04   13.5   0.0    1.3  1  SRP54           SRP54-type protein, GTPase domain
      0.034   14.0   0.8       0.16   11.8   0.8    2.2  1  Pox_A_type_inc  Viral A-type inclusion protein repeat
      0.069   13.4   0.0       0.16   12.2   0.0    1.6  1  AAA_22          AAA domain
       0.12   12.3   0.2       0.51   10.2   0.1    2.2  2  NuA4            Histone acetyltransferase subunit NuA4
       0.17   11.5   0.1       0.38   10.3   0.1    1.7  1  cobW            CobW/HypB/UreG, nucleotide-binding domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.6   5.9e-08   9.6e-05      25     150 ..      19     136 ..       4     219 .. 0.59

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 5.9e-08
                 EEEEEESTTSSHHHHHHHHHHHCS--.--HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH............. CS
     G-alpha  25 kllllGqseSGKsTilkqlkllykkg.fseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliaklssateee... 119
                 ++lllG ++SGK+ ++++l  + ++  ++ e+l++   +i + +++++ ++l++++ +  e       +  +++  ++++v++ l + + +    +   
  EFC36693.1  19 TILLLGFEGSGKTVFIRSLASYTQQDiYKSEKLEI---LITNRCIDAFASLLNEMNDQVREE----VFRISSDDSLEIQNVKKVLGSPTPNV---Twfn 107
                 79******************888666366666677...9****************9964444....23333444444444444332211111...1111 PP

                 HHCCHHC.-HCHHHHHHHHCCSH.HHHHHHCCG CS
     G-alpha 120 qeiefnp.raevgedikaLwndp.giqelyerr 150
                       +   + +  +++Lw++   ++e+ ++r
  EFC36693.1 108 I----LKgFSDNYLLFVELWKSTvQVREFAKER 136
                 1....1111122334555553332444444433 PP

>> Chordopox_G2  Chordopoxvirus protein G2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   2.1e-06    0.0035     158     202 ..      37      85 ..      29      96 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 2.1e-06
  Chordopox_G2 158 ffaylvakivsNkdievvVtekCid...ellkeenaellkkvfdkgs.d 202
                   ++ y++++i   +++e+++t++Cid   +ll+e n ++ ++vf+ +s d
    EFC36693.1  37 LASYTQQDIYKSEKLEILITNRCIDafaSLLNEMNDQVREEVFRISSdD 85 
                   56799999****************94445899***********988844 PP

>> ERK-JNK_inhib  ERK and JNK pathways, inhibitor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.1   2.8e-06    0.0046      32      92 ..     143     205 ..     129     215 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.8e-06
  ERK-JNK_inhib  32 ksllkiddyekqyklvei..llkkilkvleeskekLekadilpesdfpkdeklkdAlssvlEN 92 
                    +++ +  +y+k + l++   + +++lk +++++e +++++i+p  ++ +  ++k+ lssv+EN
     EFC36693.1 143 NNWTNFANYDKFFSLLDRgrISTDLLKYMSQKRERISDLKINPTGEVYNLVDVKNRLSSVTEN 205
                    689999999999999985337899*************************************** PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.0   3.3e-06    0.0054      24      62 ..      15      51 ..       7     219 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3.3e-06
      AAA_16 24 p..elvllsGesGvGKsslvrellralekdggiflrgkcdq 62
                p  + +ll G  G+GK+  +r+l+ + ++d    ++   + 
  EFC36693.1 15 PplPTILLLGFEGSGKTVFIRSLASYTQQD----IYKSEKL 51
                24689*******************555554....3322222 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.0     2e-05     0.032       1      55 [.      20      76 ..      20      95 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2e-05
                EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCS..SSSTTHHHHHHHHHHHHHHH CS
         AAA  1 vllyGppGtGKTllakavakelgvefleisgsell..skyvgesekkirelfkeake 55
                +ll G  G GKT +++++a+ +++++++ +  e+l  +  + + ++ ++e+ ++++e
  EFC36693.1 20 ILLLGFEGSGKTVFIRSLASYTQQDIYKSEKLEILitNRCIDAFASLLNEMNDQVRE 76
                699*******************99988888888775555677777777666666655 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   2.1e-05     0.034       2      45 ..      19      60 ..      18      95 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.1e-05
                CEEEEC-TTTCHHHHHHHHHHHHCTS-SCCCC-SEEEEEETTTT CS
       NACHT  2 lvilqGeaGsGKTtLlqklalawaegklpqgafklvFflslrel 45
                +++l G  GsGKT+++++la+  +++ ++++  kl ++++ r++
  EFC36693.1 19 TILLLGFEGSGKTVFIRSLASYTQQDIYKSE--KLEILITNRCI 60
                789******************9999887775..55555555555 PP

>> SRP54  SRP54-type protein, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   2.5e-05      0.04       3      31 ..      19      47 ..      17      80 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.5e-05
                EEEEEESTTSSHHHHHHHHHHHHHHTTS- CS
       SRP54  3 villvGlqGaGKTttlaKLaallkkegkk 31
                 ill+G++G+GKT  +  La + +++ +k
  EFC36693.1 19 TILLLGFEGSGKTVFIRSLASYTQQDIYK 47
                599*******************9988443 PP

>> Pox_A_type_inc  Viral A-type inclusion protein repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.8    0.0001      0.16       3      14 ..     171     182 ..     171     182 .. 0.96

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.0001
  Pox_A_type_inc   3 msrlRsRIsDLE 14 
                     ms++R+RIsDL+
      EFC36693.1 171 MSQKRERISDLK 182
                     9**********7 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0    0.0001      0.16       8      64 ..      20      74 ..      18      99 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.0001
      AAA_22  8 lvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsst..sskdllrellral 64
                +++ G  G+GKT+ +r l++  +++++    ++e +++ +++ +    ++ll+e+  ++
  EFC36693.1 20 ILLLGFEGSGKTVFIRSLASYTQQDIY----KSEKLEILITNRCidAFASLLNEMNDQV 74
                7899***************99987776....6666666666666555555555555554 PP

>> NuA4  Histone acetyltransferase subunit NuA4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       2.4   3.9e+03      19      28 ..      41      50 ..      28      51 .. 0.72
   2 ?   10.2   0.1   0.00031      0.51      36      74 ..     104     141 ..      96     157 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.4
        NuA4 19 leeqIydkEt 28
                 ++ Iy+ E+
  EFC36693.1 41 TQQDIYKSEK 50
                5788999985 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00031
        NuA4  36 svGNiikGF.dnylk.....ssssssaaerrkrkvtdedriFSlS 74 
                 ++ Ni+kGF dnyl      +      ++ + r++  ++riFS+S
  EFC36693.1 104 TWFNILKGFsDNYLLfvelwK------STVQVREF-AKERIFSNS 141
                 566***********9543220......22222333.467888887 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.1   0.00024      0.38       1      22 [.      18      41 ..      18      76 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00024
                EEEEEEESTTCCHHHHHHHHH..C CS
        cobW  1 pvtvltGflGsGKTtLlnhll..e 22
                p+++l Gf GsGKT ++++l   +
  EFC36693.1 18 PTILLLGFEGSGKTVFIRSLAsyT 41
                578999************998552 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (242 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       785  (0.0437838); expected 358.6 (0.02)
Passed bias filter:                      553  (0.0308439); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1513.82
//
Query:       EFC36694.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-13   49.6   0.8    0.00025   20.9   0.0    4.1  4  TPR_2        Tetratricopeptide repeat
    2.6e-12   46.0   0.4    0.00028   20.6   0.0    3.8  4  TPR_1        Tetratricopeptide repeat
    1.4e-07   31.7   0.1    0.00077   19.7   0.0    2.6  2  TPR_12       Tetratricopeptide repeat
    0.00016   21.9   0.5    0.00016   21.9   0.5    1.8  2  Med15_fungi  Mediator complex subunit 15
    0.00099   18.7   0.0        4.2    7.1   0.0    3.5  3  TPR_11       TPR repeat
     0.0016   18.5   1.2        2.3    8.7   0.0    3.7  3  TPR_8        Tetratricopeptide repeat
     0.0029   17.7   0.0       0.25   11.5   0.0    2.9  3  TPR_9        Tetratricopeptide repeat
     0.0054   17.3   0.0        3.2    8.6   0.0    3.5  3  TPR_6        Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.031   14.3   0.1        1.5    9.0   0.0    3.4  3  TPR_7        Tetratricopeptide repeat
       0.11   12.5   0.0        7.4    6.6   0.0    2.6  2  TPR_10       Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       7.8   1.4e+04      17      22 ..      25      30 ..      22      31 .. 0.69
   2 !   15.7   0.0   6.3e-06     0.011       5      30 ..     133     158 ..     131     161 .. 0.93
   3 !    8.7   0.1    0.0011         2       2      32 ..     228     258 ..     227     260 .. 0.91
   4 !   20.9   0.0   1.4e-07   0.00025       2      32 ..     267     297 ..     266     297 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 7.8
       TPR_2 17 yeeAle 22
                ++eA++
  EFC36694.1 25 WDEAIR 30
                788886 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 6.3e-06
       TPR_2   5 ynlGlayyklgdyeeAleafekAlel 30 
                 y +Gl++  lg++ eA+++f+ A+++
  EFC36694.1 133 YLMGLCCDGLGEFSEAVQHFRNAIKH 158
                 789*********************97 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0011
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldP 32 
                 e++ + Gl+yy    y + + +++kA+ l +
  EFC36694.1 228 ELYIRAGLSYYLETFYSDSIIYLNKAITLGE 258
                 6899***********************9865 PP

  == domain 4  score: 20.9 bits;  conditional E-value: 1.4e-07
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldP 32 
                   +yn+Gl  y+lgd++ A+++f k+++l P
  EFC36694.1 267 SSYYNRGLGKYYLGDWKGAIQDFSKSISLMP 297
                 579**************************98 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       4.3   7.7e+03       4      25 ..      82     103 ..      80     108 .. 0.72
   2 !   20.5   0.0   1.7e-07    0.0003       5      31 ..     133     159 ..     129     161 .. 0.91
   3 ?   -0.2   0.0      0.57     1e+03      17      30 ..     243     256 ..     243     260 .. 0.75
   4 !   20.6   0.0   1.6e-07   0.00028       1      31 [.     266     296 ..     266     297 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4.3
                 HHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   4 lynlGnayfklgkydeAleyye 25 
                 l ++  a ++ ++++ A ++  
  EFC36694.1  82 LTQRCIARLQTKEWKFAKQDLI 103
                 6677788888899999988865 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 1.7e-07
                 HHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   5 ynlGnayfklgkydeAleyyekALeln 31 
                 y +G+++  lg++ eA+++++ A++++
  EFC36694.1 133 YLMGLCCDGLGEFSEAVQHFRNAIKHR 159
                 89**********************986 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.57
                 HHHHHHHHHHHHHH CS
       TPR_1  17 ydeAleyyekALel 30 
                 y + + y +kA++l
  EFC36694.1 243 YSDSIIYLNKAITL 256
                 56677899999988 PP

  == domain 4  score: 20.6 bits;  conditional E-value: 1.6e-07
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   1 akalynlGnayfklgkydeAleyyekALeln 31 
                 a ++yn+G+  ++lg+++ A+++++k ++l 
  EFC36694.1 266 ASSYYNRGLGKYYLGDWKGAIQDFSKSISLM 296
                 678*************************985 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00072       1.3      49      76 ..     133     160 ..     130     162 .. 0.83
   2 !   19.7   0.0   4.3e-07   0.00077       5      74 ..     229     295 ..     225     297 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00072
      TPR_12  49 rnLgrlyralgryeeAlelleealaiae 76 
                 + +g +++ lg++ eA+++++ a++ +e
  EFC36694.1 133 YLMGLCCDGLGEFSEAVQHFRNAIKHRE 160
                 5689999999999999999999988877 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 4.3e-07
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                 ++ + ++ ++    y +++ +l+ka+ + ++    +++l+a++++n g   ++lg+++ A++ + +++ +
  EFC36694.1 229 LYIRAGLSYYLETFYSDSIIYLNKAITLGEE---NNSELVASSYYNRGLGKYYLGDWKGAIQDFSKSISL 295
                 6677899999999****************55...5899************************99999876 PP

>> Med15_fungi  Mediator complex subunit 15
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.5   8.9e-08   0.00016       6      84 ..      21      96 ..      18     108 .. 0.89
   2 ?   -1.9   0.1       2.2     4e+03       5      38 ..     164     198 ..     160     209 .. 0.71

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 8.9e-08
  Med15_fungi  6 klkqiyeevaknavrlkpitnlspeqKaaikqqlqeiqqmlarvdaliplfykltkneea.vkrLlqmrimlkeqleklp 84
                 +l++++e +++n++r   +     + K+  k+q++e+q+ ++++++li  f +l+++e++ +++Ll+ r++ + q+++ +
   EFC36694.1 21 NLRSWDEAIRANNLRIYELI----NRKNYTKEQTHELQDNYSEIQELIENFHILNSSERNeLRKLLTQRCIARLQTKEWK 96
                 68899999999999888888....799***************************99987659*************99755 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 2.2
  Med15_fungi   5 eklkqiyeevaknavrlkpitn.lspeqKaaikqq 38 
                  + lk  +e+++k+ ++l+     ++ e+K+++ ++
   EFC36694.1 164 QVLKVGKEDLEKKLIKLEEPFFlVQMEEKKSMEEK 198
                  55666677777777777777666778888887765 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.0    0.0025       4.4       7      22 ..     142     157 ..     142     161 .. 0.91
   2 ?   -0.2   0.1      0.46   8.2e+02      28      36 ..     266     274 ..     243     276 .. 0.81
   3 !    7.1   0.0    0.0023       4.2       5      25 ..     277     297 ..     273     306 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0025
      TPR_11   7 qGkyeeAieaYkkAlk 22 
                 +G++ eA++++++A+k
  EFC36694.1 142 LGEFSEAVQHFRNAIK 157
                 69*************8 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.46
      TPR_11  28 aeayynLGl 36 
                 a+ yyn+Gl
  EFC36694.1 266 ASSYYNRGL 274
                 677999985 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0023
      TPR_11   5 yeqGkyeeAieaYkkAlkldP 25 
                 y +G++++Ai++++k + l P
  EFC36694.1 277 YYLGDWKGAIQDFSKSISLMP 297
                 889************999866 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0    0.0013       2.3       5      29 ..     133     157 ..     133     160 .. 0.95
   2 ?    2.3   0.2      0.14   2.4e+02       4      30 ..     230     256 ..     227     260 .. 0.74
   3 ?    3.9   0.0     0.044        79       1      30 [.     266     295 ..     266     298 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0013
                 HHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekale 29 
                 y++g++++ lg++ eA++ ++ a++
  EFC36694.1 133 YLMGLCCDGLGEFSEAVQHFRNAIK 157
                 789*******************997 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.14
                 HHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekalel 30 
                 y + g+ y     y  ++ y++ka++l
  EFC36694.1 230 YIRAGLSYYLETFYSDSIIYLNKAITL 256
                 6666666666666778999*****987 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.044
                 CCHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   1 aeayynlgsiylklgdyeeAkeyyekalel 30 
                 a++yyn g+    lgd + A++ + k ++l
  EFC36694.1 266 ASSYYNRGLGKYYLGDWKGAIQDFSKSISL 295
                 6799****9999***************998 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.8   3.2e+03      34      56 ..      84     106 ..      80     119 .. 0.82
   2 ?    2.3   0.0       0.1   1.8e+02      41      65 ..     141     165 ..     134     170 .. 0.82
   3 !   11.5   0.0   0.00014      0.25      31      66 ..     268     303 ..     265     309 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.8
       TPR_9  34 dRGlllaqlGclsaAladLeayl 56 
                  R +++ q   ++ A +dL + +
  EFC36694.1  84 QRCIARLQTKEWKFAKQDLIHVI 106
                 67789999999999999998766 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.1
       TPR_9  41 qlGclsaAladLeaylalapdapda 65 
                  lG +s+A++ +  ++ + ++ +++
  EFC36694.1 141 GLGEFSEAVQHFRNAIKHREEVEQV 165
                 79**************999876665 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 0.00014
       TPR_9  31 errdRGlllaqlGclsaAladLeaylalapdapdae 66 
                  ++ RGl  + lG++++A++d+   ++l p  ++++
  EFC36694.1 268 SYYNRGLGKYYLGDWKGAIQDFSKSISLMPVTEQRY 303
                 6899*******************9999999888876 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0    0.0018       3.2       4      28 ..     133     157 ..     131     159 .. 0.93
   2 ?   -0.5   0.0       1.4   2.5e+03       5      27 ..     232     254 ..     229     256 .. 0.70
   3 ?    3.9   0.0     0.056     1e+02       2      25 ..     268     291 ..     267     294 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0018
                 HHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   4 yklalsyrklgdtdkAlealerlik 28 
                 y+++l+   lg+ ++A++ +++ ik
  EFC36694.1 133 YLMGLCCDGLGEFSEAVQHFRNAIK 157
                 99*******99**********9997 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealerli 27 
                 +++lsy+  + +++++ +l++ i
  EFC36694.1 232 RAGLSYYLETFYSDSIIYLNKAI 254
                 67899998666667776776665 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.056
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealer 25 
                 ++y+++l  + lgd+  A++ + +
  EFC36694.1 268 SYYNRGLGKYYLGDWKGAIQDFSK 291
                 5899999999999******98865 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0        10   1.8e+04      15      20 ..      25      30 ..      22      31 .. 0.83
   2 ?    9.0   0.0   0.00085       1.5       5      33 ..     135     161 ..     133     175 .. 0.80
   3 ?    1.1   0.0      0.28   5.1e+02      12      24 ..     279     291 ..     268     302 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 10
       TPR_7 15 yeeAie 20
                ++eAi+
  EFC36694.1 25 WDEAIR 30
                999996 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00085
       TPR_7   5 LarlysrlGdyeeAielyeqsLaltkdpe 33 
                 ++ ++  lG+++eA+++++   a+  ++e
  EFC36694.1 135 MGLCCDGLGEFSEAVQHFRN--AIKHREE 161
                 66777779**********99..7665554 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.28
       TPR_7  12 lGdyeeAielyeq 24 
                 lGd++ Ai+ + +
  EFC36694.1 279 LGDWKGAIQDFSK 291
                 8999999986655 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.1     0.053        95      15      35 ..     142     162 ..     141     164 .. 0.87
   2 ?    6.6   0.0    0.0041       7.4       1      30 [.     265     294 ..     265     296 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.053
      TPR_10  15 rgrydeAealleealairrrl 35 
                 +g++ eA+++++ a+  r+++
  EFC36694.1 142 LGEFSEAVQHFRNAIKHREEV 162
                 699***********9877765 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0041
      TPR_10   1 tAsslnNLanalrqrgrydeAealleeala 30 
                 +Ass+ N +   + +g++++A +++ ++++
  EFC36694.1 265 VASSYYNRGLGKYYLGDWKGAIQDFSKSIS 294
                 79*********************9988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1447  (0.0807072); expected 358.6 (0.02)
Passed bias filter:                      674  (0.0375927); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 1846.25
//
Query:       EFC36695.1  [L=593]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
        1.3    9.1  14.0       0.91    9.5   1.9    2.3  2  Mucin        Mucin-like glycoprotein


Domain annotation for each model (and alignments):
>> Mucin  Mucin-like glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   1.9   5.1e-05      0.91      31      77 ..     294     338 ..     259     362 .. 0.61
   2 ?    4.6   4.5    0.0016        29      32      69 ..     545     582 ..     527     584 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 5.1e-05
       Mucin  31 sdaavveaaegqskltttttttkppttttttttasttittkttkatt 77 
                 +d+av  a +++++++ttt t   +   tt + +s+ +t +  ++ +
  EFC36695.1 294 KDEAVELAVQSNNQSNTTTNTS--TNNNTTNNNTSNNQTNQFNQTNQ 338
                 4444444444444444433332..22222222223332222222222 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0016
       Mucin  32 daavveaaegqskltttttttkppttttttttasttit 69 
                  ++  ++++++++   t+++++p tt tt tt ++t+t
  EFC36695.1 545 SSQLLSSTNTDNQDFDTSISLHPHTTGTTNTTGASTTT 582
                 56777889999999999999999999998887766644 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (593 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2668  (0.148809); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.34s 00:00:01.06 Elapsed: 00:00:00.53
# Mc/sec: 3372.37
//
Query:       EFC36696.1  [L=659]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.1e-40  137.6   0.9      7e-35  121.0   0.4    3.5  3  PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase
    1.8e-21   76.4   2.0    3.7e-21   75.4   2.0    1.4  1  PI3Ka           Phosphoinositide 3-kinase family, accessory d
  ------ inclusion threshold ------
       0.22   11.3   2.4        7.5    6.3   1.2    2.6  2  T6SS_VipA       Type VI secretion system, VipA, VC_A0107 or H


Domain annotation for each model (and alignments):
>> PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       1.7     1e+04       3      19 ..     196     212 ..     195     220 .. 0.78
   2 !  121.0   0.4   1.2e-38     7e-35       3     215 ..     308     479 ..     306     483 .. 0.91
   3 !    6.2   0.0    0.0013       7.8     208     248 ..     565     605 ..     557     607 .. 0.93

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 1.7
                     EEEEECSSCHHHHHHHH CS
  PI3_PI4_kinase   3 agiykvgddlrqdeliv 19 
                     +++++v+ d+rq+ li 
      EFC36696.1 196 GLLVPVEKDKRQERLIE 212
                     67889999****87765 PP

  == domain 2  score: 121.0 bits;  conditional E-value: 1.2e-38
                     EEEEECSSCHHHHHHHHHHHHHHHHHHHHTTTTCCCT-------EEESSSSEEEEE--TTEEEHHHHHHHHHHHCTTSTCHHHHHHHHHCHCHCC CS
  PI3_PI4_kinase   3 agiykvgddlrqdelivqvfklmdeelskennpkrrklalktysviplgrkcgiielvassetaaslldeklekkgvpptasveslrvaldkkkl 97 
                     + i+k+gdd+r+d+l +q++++++ + ++  +p+     l +y+vi +gr+ giie+v++s++ +++ d                          
      EFC36696.1 308 PCIFKAGDDCRHDQLALQIISMFQRVYERIELPLY----LFPYRVITTGRGLGIIECVPNSKSRHQIGDSIN----------------------- 375
                     579*******************************9....******************************955....................... PP

                     HHHHHCCHHHHHHTSSTTHHHHHHHHHSSSHH..HHHHHHHHHHHHHHHHHHHHHHHT-TT--TTTEEEETTTSEEEESSTTTCC.TCSHCSSSS CS
  PI3_PI4_kinase  98 kkekklkfekrtalkpksgllqeFvkkspsae..ewlearkqFvrslaklsvldyilgngDRhldNilvdktsgklihIDfGlil.pdewkllpf 189
                                      + l+++F++k+ +++  e+++ar +F+ s+a +s++++il + DRh++Ni++ +++g++ihIDfG+i+    + ++++
      EFC36696.1 376 ---------------AGDNLYNYFIRKYGNVHtvEFQRARMNFIHSMAAYSIVSFILSIKDRHNGNIML-DEDGHVIHIDFGFIFdILPGGKFGI 454
                     ...............369*************54499999******************************.***************3334555666 PP

                     -.SSSSSS-THHHHHHTSTTCCHHHH CS
  PI3_PI4_kinase 190 pqekvPfrltrelvlaidpskdeglf 215
                     + + vPf+lt e+ +++++ + ++  
      EFC36696.1 455 E-QVVPFKLTTEMLALMGEEQAIEES 479
                     8.899************988877665 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0013
                     TTCCHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHCCSS CS
  PI3_PI4_kinase 208 pskdeglfresceealealrrdqnlltrllkkavkdglilw 248
                      s+ ++lf +++ + + a+r +++ ++++ + +v++gl+++
      EFC36696.1 565 HSEPYNLFVDLMIRGYLAARDHMDSIIAISEVMVQSGLPCF 605
                     57889*********************************987 PP

>> PI3Ka  Phosphoinositide 3-kinase family, accessory domain (PIK domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.4   2.0   6.1e-25   3.7e-21      50     165 ..      35     148 ..       6     160 .. 0.81

  Alignments for each domain:
  == domain 1  score: 75.4 bits;  conditional E-value: 6.1e-25
                 HHTTS-SSSHHHHHHHHHHHTTSHHTTHHHHTTTTSTTS--.HHHHHHHHHHHHHSHHHHHHHHHHHHHHHHGGSSSSSSHHHHHHHHHHHHSHHHHHH CS
       PI3Ka  50 lLqsvkwseesevkealelldsWaeididdaLeLLdskfkd.esvreyavkvLekasdeelllYllQLVqalkyepikdsalaefLlkralknkrlghf 147
                 l++  +    + + ++l++l  W +     +L +L+  f +  +v++ya++ L+k+s e++ +Yl+Q+Vq+l+++   +  l++f+++  ++++ + h+
  EFC36696.1  35 LINELNC---KMNSNELNHLLIWSTCTLSMSLRYLNKPFISnLNVQQYAIRTLRKFSPEAIVFYLPQIVQCLRHD--YNHLLKRFIISIVKNSVMFTHQ 128
                 4443333...4455899**********************887*********************************..999******************* PP

                 HHHHHHHHH.HCCTH.HHHH CS
       PI3Ka 148 ffWyLksei.edkev.serf 165
                 ++W L++ei e++++  e++
  EFC36696.1 129 LIWTLRTEIvESNHLtLEEL 148
                 *********63333324444 PP

>> T6SS_VipA  Type VI secretion system, VipA, VC_A0107 or Hcp2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.013        75      85     114 ..      73     103 ..      36     130 .. 0.79
   2 ?    6.3   1.2    0.0013       7.5      52     109 ..     270     328 ..     265     339 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.013
                 EEEEE.EEE-SGGGGSHHHHHCC-HHHHHHH CS
   T6SS_VipA  85 elavd.LkfeslkDFsPeavaeqvpeLkkLl 114
                 +l+v+   +++l  FsPea++   p++ + l
  EFC36696.1  73 NLNVQqYAIRTLRKFSPEAIVFYLPQIVQCL 103
                 5666427899***********9999987765 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0013
                 -EEE-TTSHHHHHHHHTEEEEEEEE.--SSS-S-EEEEEEEE-SGGGGSHHHHHCC-HH CS
   T6SS_VipA  52 fveidkdnfdevlkeikprlalkVe.ntLsedgselavdLkfeslkDFsPeavaeqvpe 109
                  v+++++n++  +++++ +++ +   nt +++++++++   f+  +D + +++a q+ +
  EFC36696.1 270 DVNMNQNNMNGNMNNMNGNMNGNNMnNTTQNNQNNIKLPCIFKAGDDCRHDQLALQIIS 328
                 5899****************987550555555888999999******999999999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (659 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1127  (0.0628591); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3979.59
//
Query:       EFC36697.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.16   11.6   5.9       0.03   14.0   2.6    1.4  1  PIP49_C   Protein-kinase domain of FAM69
       0.96   10.1  13.9        2.3    8.9  14.0    1.6  1  Fz        Fz domain


Domain annotation for each model (and alignments):
>> PIP49_C  Protein-kinase domain of FAM69
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   2.6   3.4e-06      0.03      87     156 ..      52     121 ..      50     126 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.4e-06
     PIP49_C  87 cdvslenfgvsddgrlkliDldnvfiedkleeklseqkcekdedcsffdclskcdkeedrCsaevensnl 156
                 c +  + + vs++  l   D + v ie+  ++   ++++  ++d s++ c + c+k+++ C++ +  sn+
  EFC36697.1  52 CATRSDDLEVSSNLILLTGDCRVVGIEQACSRYDPKNQKYVNNDGSYRICKAWCEKRKSTCNDPTDCSNY 121
                 5566667778888889999**********999999999999**********************9999998 PP

>> Fz  Fz domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9  14.0   0.00025       2.3       1      92 [.      17     118 ..      16     133 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00025
                 -EE-.E...ETT-.S.-SEE-.....GGGS.S-SSHHHHHHH.....HHHHHGGGG-HHHTTSTTHHHHHHS---EESSS-EEEE---HHHHHHHHTT- CS
          Fz   1 Cepi.elelCkai.g.ynsts.....lpnllgheteeevaee.....leefsllvkleCspalklflCsllfpkCepsgeeeaplppCrslCeavrdsC 86 
                 C+++   ++Ck i + +n+++      ++ +g ++    a++     +++   l++ +C+    +  Cs + pk ++ ++++ + ++C+ +Ce+ ++ C
  EFC36697.1  17 CTQYtMAQTCK-IgTlFNQSPkqctdCTTCTGANPTC--ATRsddleVSSNLILLTGDCRVVGIEQACSRYDPKNQKYVNNDGSYRICKAWCEKRKSTC 112
                 77776557777.4233465542222212222222222..122111113333444444*******************999******************** PP

                 GGGSTT CS
          Fz  87 ekvlae 92 
                 ++    
  EFC36697.1 113 NDPTDC 118
                 985533 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       965  (0.0538234); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 916.05
//
Query:       EFC36698.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.2    9.3   5.9       0.11   12.7   1.7    1.5  2  FRG2      Facioscapulohumeral muscular dystrophy candidate 2


Domain annotation for each model (and alignments):
>> FRG2  Facioscapulohumeral muscular dystrophy candidate 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1      0.54   9.8e+03      83     103 ..       7      27 ..       4      31 .. 0.64
   2 ?   12.7   1.7   6.2e-06      0.11      33     122 ..      76     161 ..      44     165 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.54
        FRG2  83 tadarerraerrgaGrskrrr 103
                 t+++ ++++ +++ Gr   rr
  EFC36698.1   7 TTKTITTQQLPKRRGRPCTRR 27 
                 566666777777777766555 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 6.2e-06
        FRG2  33 skessRkRkisSrdsscqgtGa.sladersvtlekkkrkasdegrssesqetadarerraerrgaGrskrrrsrspgdrppplRKsLVtsl 122
                  + +  kRk sS++s+ ++  + +  d     lekk++   d      ++++ +++++ a   ++ +++r++s  +g+  pp RK + ts+
  EFC36698.1  76 TNSNINKRKRSSSNSTITNNTSyNNIDCIHQPLEKKSKLIEDY-----IESNDATSPQLALLSKPNHQQRSSSDIKGVISPPNRKIIRTSI 161
                 5567789*******99988866244455667788888885554.....4555566677777778889******************999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1313  (0.0732333); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1027.06
//
Query:       EFC36699.1  [L=140]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (140 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       858  (0.0478554); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 932.20
//
Query:       EFC36700.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0037   17.0   1.0     0.0055   16.4   1.0    1.2  1  Casc1_N   Cancer susceptibility candidate 1 N-terminus
  ------ inclusion threshold ------
       0.56   10.3   6.6        1.1    9.4   6.6    1.5  1  AT_hook   AT hook motif


Domain annotation for each model (and alignments):
>> Casc1_N  Cancer susceptibility candidate 1 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   1.0   6.2e-07    0.0055      77     122 ..     137     182 ..     136     200 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 6.2e-07
     Casc1_N  77 ecdglPdptdekeiNtflslwseeeeedieevmetctlvlklieeL 122
                 +c+++P  t+   +N+f++  s++++ di++ +++c++ ++   ++
  EFC36700.1 137 NCHHSPSSTNNNNVNNFIMMKSNDDNIDIDNNTRRCSMFVNYQCDV 182
                 7***********************************9988877766 PP

>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.6   0.00012       1.1       1      12 [.      29      40 ..      29      41 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00012
     AT_hook  1 kRkRGRPrKaat 12
                kR+RGRP+K+ +
  EFC36700.1 29 KRRRGRPAKNDP 40
                8********976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       763  (0.0425568); expected 358.6 (0.02)
Passed bias filter:                      201  (0.0112109); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 1456.85
//
Query:       EFC36701.1  [L=280]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-59  192.1  16.7    0.00015   21.5   0.1   12.0 12  LRR_6     Leucine Rich repeat
    4.9e-33  112.7  22.2    7.4e-06   25.6   0.5    5.3  7  LRR_8     Leucine rich repeat
    7.9e-31  105.6   8.1    0.00046   20.5   0.0    7.0  9  LRR_4     Leucine Rich repeats (2 copies)
    1.1e-16   58.7   0.1        2.3    9.1   0.0   11.0 12  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   4.2e-06     0.019       5      24 .]       4      23 ..       2      23 .. 0.92
   2 !   14.2   0.1   7.4e-06     0.033       5      24 .]      28      47 ..      25      47 .. 0.91
   3 !   20.0   0.0     1e-07   0.00046       5      24 .]      52      71 ..      49      71 .. 0.92
   4 !   17.0   0.0   9.4e-07    0.0042       3      24 .]      74      95 ..      72      95 .. 0.91
   5 !   20.8   0.1   5.6e-08   0.00025       4      24 .]      99     119 ..      96     119 .. 0.90
   6 !   11.6   0.0   5.3e-05      0.24       5      24 .]     124     143 ..     120     143 .. 0.92
   7 !   17.5   0.0   6.7e-07     0.003       3      24 .]     146     167 ..     144     167 .. 0.90
   8 !   19.6   0.1   1.4e-07   0.00061       3      24 .]     170     191 ..     168     191 .. 0.91
   9 !   13.0   0.0   1.8e-05      0.08       5      24 .]     196     215 ..     192     215 .. 0.92
  10 !   21.5   0.1   3.3e-08   0.00015       3      24 .]     218     239 ..     216     239 .. 0.91
  11 !   11.2   0.0     7e-05      0.31       5      24 .]     244     263 ..     241     263 .. 0.91
  12 !   10.3   0.1   0.00014      0.61       5      16 ..     268     279 ..     265     280 .] 0.92

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 4.2e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt Ld+ +N+Ig eGa+ ++
  EFC36701.1  4 LTLLDIGYNQIGVEGAKLIS 23
                899*************9985 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 7.4e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt L++  N+IgDeGa+ ++
  EFC36701.1 28 LTLLNIGTNEIGDEGAIMIS 47
                899*************9986 PP

  == domain 3  score: 20.0 bits;  conditional E-value: 1e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt Ld+ gN+I+DeGa +++
  EFC36701.1 52 LTFLDIGGNQISDEGARSIS 71
                999*************9986 PP

  == domain 4  score: 17.0 bits;  conditional E-value: 9.4e-07
       LRR_6  3 thLteLdLsgNdIgDeGaeaLa 24
                + Lt Ld+ gN+IgD+Ga++++
  EFC36701.1 74 RQLTFLDIYGNGIGDKGAKSIS 95
                679****************996 PP

  == domain 5  score: 20.8 bits;  conditional E-value: 5.6e-08
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt L++ gN+IgDeGa+ ++
  EFC36701.1  99 QLTLLNIGGNQIGDEGAKLIS 119
                 6999**************986 PP

  == domain 6  score: 11.6 bits;  conditional E-value: 5.3e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+ +N+I+ eGa++++
  EFC36701.1 124 LTFLDIYCNEIDVEGAKCIS 143
                 999**************996 PP

  == domain 7  score: 17.5 bits;  conditional E-value: 6.7e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt+L++ +N+Ig eG++ L+
  EFC36701.1 146 QQLTSLNIGSNEIGVEGVKFLS 167
                 57****************9885 PP

  == domain 8  score: 19.6 bits;  conditional E-value: 1.4e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt+L++  N IgDeGa+ ++
  EFC36701.1 170 QQLTSLNIGENLIGDEGAKLIS 191
                 57*****************986 PP

  == domain 9  score: 13.0 bits;  conditional E-value: 1.8e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+ +N+Ig eGa++++
  EFC36701.1 196 LTFLDIYCNEIGVEGAKSIS 215
                 999**************996 PP

  == domain 10  score: 21.5 bits;  conditional E-value: 3.3e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt+L++  N+IgDeGa+ ++
  EFC36701.1 218 QQLTSLNIGENGIGDEGAKLIS 239
                 57*****************986 PP

  == domain 11  score: 11.2 bits;  conditional E-value: 7e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+ +N+Ig eGa+ ++
  EFC36701.1 244 LTFLDIYCNEIGVEGAKYIS 263
                 999*************9885 PP

  == domain 12  score: 10.3 bits;  conditional E-value: 0.00014
       LRR_6   5 LteLdLsgNdIg 16 
                 Lt+L++s N+Ig
  EFC36701.1 268 LTSLNISNNQIG 279
                 9**********8 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.1   2.7e-09   1.2e-05       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   23.1   0.0     1e-08   4.5e-05       2      61 .]      27      86 ..      27      86 .. 0.97
   3 !   18.3   0.1   3.2e-07    0.0014       1      59 [.      74     132 ..      74     134 .. 0.93
   4 !   24.8   0.1     3e-09   1.3e-05       2      61 .]      99     158 ..      98     158 .. 0.97
   5 !   25.6   0.5   1.6e-09   7.4e-06       2      59 ..     147     204 ..     146     206 .. 0.94
   6 !   22.9   0.2   1.2e-08   5.2e-05       2      61 .]     171     230 ..     170     230 .. 0.97
   7 !   25.6   0.1   1.7e-09   7.4e-06       2      61 .]     219     278 ..     218     278 .. 0.98

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 2.7e-09
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +Lt Ld+  N++ + + +  + +++L+ L+++ N++    + ++s +++L++Ld+ gN++
  EFC36701.1  3 QLTLLDIGYNQIGVEGAKLISEMKQLTLLNIGTNEIGDEGAIMISEMKQLTFLDIGGNQI 62
                79********************************************************98 PP

  == domain 2  score: 23.1 bits;  conditional E-value: 1e-08
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +Lt L++  N + + +  + + +++L+ Ld++ N+++   ++++s +++L++Ld+ gN +
  EFC36701.1 27 QLTLLNIGTNEIGDEGAIMISEMKQLTFLDIGGNQISDEGARSISKMRQLTFLDIYGNGI 86
                5999*****************************************************976 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 3.2e-07
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 ++Lt Ld+  N + + + ++ + +++L+ L+++ N++    ++ +s++++L++Ld+  N
  EFC36701.1  74 RQLTFLDIYGNGIGDKGAKSISEMQQLTLLNIGGNQIGDEGAKLISQMKQLTFLDIYCN 132
                 57999*************************************************98655 PP

  == domain 4  score: 24.8 bits;  conditional E-value: 3e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L++  N++ + + +  +++++L+ Ld+ +N++++  ++++s + +L+sL++ +N +
  EFC36701.1  99 QLTLLNIGGNQIGDEGAKLISQMKQLTFLDIYCNEIDVEGAKCISEMQQLTSLNIGSNEI 158
                 79********************************************************86 PP

  == domain 5  score: 25.6 bits;  conditional E-value: 1.6e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +LtsL++ +N + + + ++ + +++L++L++++Nl+    ++ +s++++L++Ld+  N
  EFC36701.1 147 QLTSLNIGSNEIGVEGVKFLSEMQQLTSLNIGENLIGDEGAKLISQMKQLTFLDIYCN 204
                 8****************************************************98655 PP

  == domain 6  score: 22.9 bits;  conditional E-value: 1.2e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  N + + + +  +++++L+ Ld+ +N++ +  ++++s + +L+sL++  N +
  EFC36701.1 171 QLTSLNIGENLIGDEGAKLISQMKQLTFLDIYCNEIGVEGAKSISEMQQLTSLNIGENGI 230
                 8******************************************************99976 PP

  == domain 7  score: 25.6 bits;  conditional E-value: 1.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  N + + + +  + +++L+ Ld+ +N++ +  ++ +s +++L+sL++s+N++
  EFC36701.1 219 QLTSLNIGENGIGDEGAKLISEMKQLTFLDIYCNEIGVEGAKYISEMKQLTSLNISNNQI 278
                 8*********************************************************98 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   2.8e-06     0.013       1      38 [.       2      40 ..       2      43 .. 0.84
   2 !   20.5   0.0     1e-07   0.00046       1      36 [.      50      86 ..      50      90 .. 0.87
   3 !   19.1   0.0   2.8e-07    0.0012       1      39 [.      98     136 ..      98     144 .. 0.86
   4 ?    4.6   0.0      0.01        46      22      36 ..     145     158 ..     138     167 .. 0.73
   5 !   16.3   0.2   2.2e-06      0.01       1      38 [.     146     184 ..     146     187 .. 0.82
   6 !   16.2   0.1   2.3e-06      0.01       1      36 [.     170     206 ..     170     216 .. 0.86
   7 !   12.2   0.0   4.2e-05      0.19       1      38 [.     194     232 ..     194     239 .. 0.81
   8 !   15.0   0.0   5.4e-06     0.024       1      36 [.     218     254 ..     218     258 .. 0.87
   9 !   18.4   0.4   4.7e-07    0.0021       1      36 [.     242     278 ..     242     279 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 2.8e-06
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38
                ++L+ Ld++ Nq+   +  l + +++L+ L++ g n i+d
  EFC36701.1  2 KQLTLLDIGYNQIGVEGAkLISeMKQLTLLNI-GTNEIGD 40
                589***********766696655*********.7778876 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 1e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++Ld+++Nq++d +   ++k+ +L+ Ld+ gN  i
  EFC36701.1 50 KQLTFLDIGGNQISDEGArsISKMRQLTFLDIYGN-GI 86
                58*************99965558*********999.65 PP

  == domain 3  score: 19.1 bits;  conditional E-value: 2.8e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L+ L++++Nq+ d +   ++++++L+ Ld+  +n i d+
  EFC36701.1  98 QQLTLLNIGGNQIGDEGAklISQMKQLTFLDI-YCNEI-DV 136
                 589************99995446*********.88788.65 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.01
                 -TT--EEE-.-S--- CS
       LRR_4  22 lpnLkeLdLsgNnli 36 
                 + +L++L++ +N  i
  EFC36701.1 145 MQQLTSLNIGSN-EI 158
                 788888888445.44 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 2.2e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++++N +   +   l+ + +L++L++ +N li+d
  EFC36701.1 146 QQLTSLNIGSNEIGVEGVkfLSEMQQLTSLNIGEN-LIGD 184
                 58**********99666686666*********556.8876 PP

  == domain 6  score: 16.2 bits;  conditional E-value: 2.3e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+++ N + d +   ++++++L+ Ld+  +n i
  EFC36701.1 170 QQLTSLNIGENLIGDEGAklISQMKQLTFLDI-YCNEI 206
                 58*************99995446*********.77776 PP

  == domain 7  score: 12.2 bits;  conditional E-value: 4.2e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+  N +   +   ++ + +L++L++ +N  i+d
  EFC36701.1 194 KQLTFLDIYCNEIGVEGAksISEMQQLTSLNIGEN-GIGD 232
                 58*******99***766675445*********556.7765 PP

  == domain 8  score: 15.0 bits;  conditional E-value: 5.4e-06
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L+++ N + d +  l + +++L+ Ld+  +n i
  EFC36701.1 218 QQLTSLNIGENGIGDEGAkLISeMKQLTFLDI-YCNEI 254
                 58*************99996655*********.77666 PP

  == domain 9  score: 18.4 bits;  conditional E-value: 4.7e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++Ld+  N +   +   ++ +++L++L++ +Nn+i
  EFC36701.1 242 KQLTFLDIYCNEIGVEGAkyISEMKQLTSLNI-SNNQI 278
                 58*******99***766676445*********.55587 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.045     2e+02       2      15 ..       4      17 ..       3      25 .. 0.77
   2 ?   -1.0   0.0       1.1   4.9e+03       2      13 ..      28      39 ..      27      44 .. 0.78
   3 !    9.1   0.0   0.00052       2.3       2      22 ..      52      72 ..      51      73 .. 0.91
   4 !    5.4   0.0    0.0084        38       2      21 ..      76      95 ..      75      97 .. 0.89
   5 ?    4.3   0.0     0.019        84       2      17 ..     100     115 ..      99     121 .. 0.79
   6 ?    2.3   0.0     0.088     4e+02       2      21 ..     124     143 ..     123     145 .. 0.85
   7 ?    4.2   0.0     0.021        93       1      14 [.     147     160 ..     147     169 .. 0.78
   8 ?    1.9   0.0      0.12   5.2e+02       1      16 [.     171     186 ..     171     193 .. 0.77
   9 ?    1.8   0.0      0.12   5.6e+02       2      21 ..     196     215 ..     195     217 .. 0.82
  10 ?    2.4   0.0     0.083   3.7e+02       1      17 [.     219     235 ..     219     241 .. 0.77
  11 ?    0.7   0.0      0.29   1.3e+03       2      17 ..     244     259 ..     243     265 .. 0.75
  12 !    6.2   0.1    0.0044        20       1      12 [.     267     278 ..     267     280 .] 0.88

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.045
       LRR_1  2 LrhLdLsnnpllgl 15
                L+ Ld+++n+++  
  EFC36701.1  4 LTLLDIGYNQIGVE 17
                899******99554 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.1
       LRR_1  2 LrhLdLsnnpll 13
                L+ L+++ n ++
  EFC36701.1 28 LTLLNIGTNEIG 39
                899***988775 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00052
       LRR_1  2 LrhLdLsnnpllglppnsfqn 22
                L+ Ld+++n++++ +++s+++
  EFC36701.1 52 LTFLDIGGNQISDEGARSISK 72
                999***************987 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.0084
       LRR_1  2 LrhLdLsnnpllglppnsfq 21
                L+ Ld+ +n ++++++ s++
  EFC36701.1 76 LTFLDIYGNGIGDKGAKSIS 95
                999**********9999987 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.019
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L+ L++++n++++ ++
  EFC36701.1 100 LTLLNIGGNQIGDEGA 115
                 899*******977665 PP

  == domain 6  score: 2.3 bits;  conditional E-value: 0.088
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ Ld+  n ++  ++ +++
  EFC36701.1 124 LTFLDIYCNEIDVEGAKCIS 143
                 999******99988888886 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.021
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++L++++n ++ 
  EFC36701.1 147 QLTSLNIGSNEIGV 160
                 599*******9854 PP

  == domain 8  score: 1.9 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L+++ n +++ +
  EFC36701.1 171 QLTSLNIGENLIGDEG 186
                 599****999886655 PP

  == domain 9  score: 1.8 bits;  conditional E-value: 0.12
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ Ld+  n ++  ++ s++
  EFC36701.1 196 LTFLDIYCNEIGVEGAKSIS 215
                 999******99888887776 PP

  == domain 10  score: 2.4 bits;  conditional E-value: 0.083
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L+++ n +++ ++
  EFC36701.1 219 QLTSLNIGENGIGDEGA 235
                 599*****999876655 PP

  == domain 11  score: 0.7 bits;  conditional E-value: 0.29
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L+ Ld+  n ++  ++
  EFC36701.1 244 LTFLDIYCNEIGVEGA 259
                 999***9999866555 PP

  == domain 12  score: 6.2 bits;  conditional E-value: 0.0044
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++snn++
  EFC36701.1 267 QLTSLNISNNQI 278
                 599*******97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       187  (0.01043); expected 358.6 (0.02)
Passed bias filter:                      135  (0.0075297); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1627.45
//
Query:       EFC36702.1  [L=2777]
Description: inositol 1,4,5-triphosphate receptor [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.4e-26   92.4  18.7    1.2e-16   60.8   5.2    4.2  3  RYDR_ITPR        RIH domain
    7.4e-20   70.7   1.9    7.4e-20   70.7   1.9    8.0  7  RIH_assoc        RyR and IP3R Homology associated
      2e-19   69.6   6.5    1.3e-18   67.0   2.9    3.4  3  Ins145_P3_rec    Inositol 1,4,5-trisphosphate/ryanodine recep
    1.6e-12   47.7   1.3    2.5e-09   37.3   0.1    3.2  2  MIR              MIR domain
  ------ inclusion threshold ------
      0.019   14.2  33.1     0.0051   16.1  28.2    2.6  2  Ion_trans        Ion transport protein
        1.6    8.5   7.2        0.2   11.5   1.5    2.4  3  DNA_pol3_beta_3  DNA polymerase III beta subunit, C-terminal 


Domain annotation for each model (and alignments):
>> RYDR_ITPR  RIH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.8   5.2     4e-20   1.2e-16      27     191 ..     678     857 ..     660     865 .. 0.83
   2 !   37.8   1.1   4.4e-13   1.3e-09      71     191 ..    1342    1461 ..    1257    1468 .. 0.82
   3 ?   -0.7   0.2      0.26   7.7e+02      82     110 ..    1944    1973 ..    1897    2043 .. 0.62

  Alignments for each domain:
  == domain 1  score: 60.8 bits;  conditional E-value: 4e-20
   RYDR_ITPR  27 lmnnkvfrqrqdLlrelgvletvmemvnvLskafke..........gaaesttselseeka.....aeyk.eivvlcyrlLayfcrdsrkNqeaiakh. 108
                   +  + ++ q+ ++e ++++ +++++++L +  +           +++ +++s l+++++     ++++  +v++cyr ++ + +++  N++++ ++ 
  EFC36702.1 678 R-EGSPHTEIQNHFKEMNIIDAIFTIIDLLDNNNNAikmtstprdsSPMLRRSSMLTDNNEttvysTRFNsILVQMCYRAIKQLAKQNIVNCTHVLNKy 775
                 4.67788899*********************666658888888887444444444444444323333353267778********************999 PP

   RYDR_ITPR 109 lsylleqlarpslregpLdvlaasLmdnneLvlkylseceiqsfiellrkgyegerfLdfLrsLcvvngeaveenqnlivrlL 191
                 +  ++++l+r+   + + + l  ++++n e vl+ +  ++i++f +l++  ++++ f  fL++Lc + +  v +nq+  v lL
  EFC36702.1 776 FTTMQDHLSRDVGGQEVSNALVEIIHNNME-VLEQIPSEKINHFFKLITTRQKKPLFVSFLSNLCRCGERPVTKNQKHLVMLL 857
                 *************999999***********.**********************************************998655 PP

  == domain 2  score: 37.8 bits;  conditional E-value: 4.4e-13
   RYDR_ITPR   71 elseekaaeykeivvl.cyrlLayfcrdsrkNqeaiakhlsylleqlarpslregpLdvlaasLmdnneLvlkylseceiqsfiellrkgyegerfL 166 
                  +ls +  + +k+ ++l c +lL  f+r+ +kNq ++++++++lle ++++       + l+ ++ +n +++l ++    i+   e + + + ++  L
  EFC36702.1 1342 CLSTSYPQYIKDRLSLcCIELLTEFVRGDQKNQLELFREFRFLLEIMSNQLDTT---ELLTEIVRENDQILLSMIDPLLIKLYLEKIISVGAKSYHL 1435
                  44444444455556661569*************************555555555...******************99999888888877777888** PP

   RYDR_ITPR  167 dfLrsLcv.vngeaveenqnlivrlL 191 
                  +fLr L+  + g++++ nqn i+++L
  EFC36702.1 1436 NFLRILTCdSMGHSIPANQNEIINNL 1461
                  ******999**************998 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.26
   RYDR_ITPR   82 eivvlcyrlLayfcrdsr.kNqeaiakhls 110 
                  +    + r+L+++c++   +Nq+ + ++ s
  EFC36702.1 1944 SYAWEVLRFLQLLCEGHNlENQQMLQDQSS 1973
                  444445666666666553144443333322 PP

>> RIH_assoc  RyR and IP3R Homology associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -7.7   5.1         6   1.8e+04      23      51 ..     171     201 ..     166     241 .. 0.46
   2 ?    3.4   0.7     0.022        67      33      78 ..     623     668 ..     614     674 .. 0.87
   3 ?   -4.9   5.9         6   1.8e+04      21      21 ..     775     775 ..     681     861 .. 0.52
   4 !    7.1   0.4    0.0016       4.7      39      94 ..    1278    1384 ..    1237    1392 .. 0.61
   5 ?   -1.8   0.8      0.93   2.8e+03      10      55 ..    1657    1707 ..    1649    1760 .. 0.59
   6 !   70.7   1.9   2.5e-23   7.4e-20       8      96 ..    1947    2035 ..    1941    2040 .. 0.88
   7 ?   -0.8   0.2      0.46   1.4e+03      29      76 ..    2075    2110 ..    2061    2225 .. 0.62

  Alignments for each domain:
  == domain 1  score: -7.7 bits;  conditional E-value: 6
   RIH_assoc  23 selqnylreQkdnk..tsynlvseivdllen 51 
                 +++q+ l++ ++++    +n v+ + +l  +
  EFC36702.1 171 NKFQSHLQSLQNSNnnGAVNHVNSTNNLNAS 201
                 5566666543322212345555555443222 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.022
   RIH_assoc  33 kdnktsynlvseivdllenlskatelnskslelmlqvldtLtefvq 78 
                 ++n+ ++nl++ei  +l n+  + + +++ ++++l++l+ ++ ++ 
  EFC36702.1 623 VNNTFQINLIKEIYPILTNFDINSHYQRNDIDILLNALKLVIYLCT 668
                 689999**************99989999999999999998887775 PP

  == domain 3  score: -4.9 bits;  conditional E-value: 6
   RIH_assoc  21 h 21 
                  
  EFC36702.1 775 Y 775
                 1 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0016
   RIH_assoc   39 ynlvseivdllenlskat.............................................elnsksl......elmlqvldtLtefvqgpCpeN 84  
                  y l+ ++++ ++ l+ +                                              ++ s s+      +l l +++ Ltefv+g  ++N
  EFC36702.1 1278 YQLIYALFNRIQVLVSTStftggdtspdftlfkdtcsqlgklmkeikgtksafrnlgghelilKCLSTSYpqyikdRLSLCCIELLTEFVRGD-QKN 1373
                  666666666444444333455555555555555555555666666666666666666665555222223355567788999************.*** PP

   RIH_assoc   85 qeai.inskfl 94  
                  q ++  + +fl
  EFC36702.1 1374 QLELfREFRFL 1384
                  *9994444554 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 0.93
   RIH_assoc   10 lLrfLqllcegh.nselqnylreQkdnk.....tsynlvseivdllenlska 55  
                  lL f+  + e   n++++++l  Qk+nk       y+l+++i+++  + s +
  EFC36702.1 1657 LLPFIESFFEMVfNKDVKKMLL-QKENKeeiktIIYDLLNNITQIYLHCSSH 1707
                  5666666666551445555554.45555244434455555555554444433 PP

  == domain 6  score: 70.7 bits;  conditional E-value: 2.5e-23
   RIH_assoc    8 rklLrfLqllceghnselqnylreQkd.nktsynlvseivdllenlskatelnskslelmlqvldtLtefvqgpCpeNqeaiins.kflea 96  
                   ++LrfLqllceghn+e q++l+ Q++ n+ s++lvse+++++ +l+k   l+ ++++ ++q++++L+efvqgpC +  +++  s  ++++
  EFC36702.1 1947 WEVLRFLQLLCEGHNLENQQMLQDQSSfNRMSIDLVSECIEYVIHLFKY--LSASNIDKVIQAFNSLNEFVQGPCEQSIRTLSYSsGLFTV 2035
                  689**********************864789****************99..**************************99999555144444 PP

  == domain 7  score: -0.8 bits;  conditional E-value: 0.46
   RIH_assoc   29 lreQkdnktsynlvseivd.....llenlskatelnskslelmlqvldtLtef 76  
                  + +Q  n + ++lv +i+      l                 ++ ++ tLt +
  EFC36702.1 2075 MANQNANLKAVELVDHITLkkemnL-----------------LKTAIITLTSM 2110
                  3444444455555555544233320.................22222222222 PP

>> Ins145_P3_rec  Inositol 1,4,5-trisphosphate/ryanodine receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.41   1.2e+03      86     106 ..      33      53 ..       3      57 .. 0.60
   2 ?   -3.5   0.0       1.7     5e+03      62      88 ..      63      89 ..      55      94 .. 0.79
   3 !   67.0   2.9   4.2e-22   1.3e-18      21     198 ..     125     361 ..     114     375 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.41
                    HHHHHHHHHHHHEBTTSEEEE CS
  Ins145_P3_rec  86 lkhaadiekkqnvqYGsvilL 106
                     + ++  ++ ++++YG +i L
     EFC36702.1  33 ASSSSFTNTSNTLRYGDIISL 53 
                    345566666667888888876 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.7
                   --SHHHHHHHH..----------HHHH CS
  Ins145_P3_rec 62 rysAqkellkakkakenktslvdvlkh 88
                   + + q+++++++++++ ++s++d l+ 
     EFC36702.1 63 SSQQQQQTISSSSFDKLNNSMMDILHD 89
                   45568899999999999******8764 PP

  == domain 3  score: 67.0 bits;  conditional E-value: 4.2e-22
                    EEEEEES-S.SS-BEEEETTC--SSS-SSTGGGC-EEEE-----SHHHHHHHH..----------HHHHHHHHHHHHH.................. CS
  Ins145_P3_rec  21 ngflstlGL.vddrcvveekagdknspPkkfrdclfkicpalrysAqkellkakkakenktslvdvlkhaadiekkqn.................. 97 
                     gfls +GL +  rc +   +       k f ++lf +c+   y A+k++ k ++  ++ ++ ++    + ++++++n                  
     EFC36702.1 125 VGFLSIKGLpGHTRCGLSVDES----ILKSFDNSLFMVCQGDTYTARKKFNKFQSHLQSLQN-SNNNGAVNHVNSTNNlnassysfgssfknqqvn 215
                    4777777774455565544333....335799999999999999999999888766654333.222333333444444445567777777777788 PP

                    ...........................................EBTTSEEEEEETTTTEEEEEECCCEESSSSSSEEEEEESS--.GGGSEEEEES CS
  Ins145_P3_rec  98 ...........................................vqYGsvilLlHvkSnkyltvlkrspslrdknamrvvLdeagnvEgswfiitPa 150
                                                               ++YG+ i+L H+kS +yl vl ++ + ++k ++++ L e      + f++ P 
     EFC36702.1 216 tnnkqqvminnlnyqnqlnelkermnredqentiekerswgkpILYGQRIQLYHIKSGMYLNVLRSN-ADLEKSSLKLSLSEGDR--MCHFQFAPH 308
                    888888999999999999999999999999999*******************************988.************87665..9******** PP

                    STTS-TTSBEBSCEEEEEEESSS-S-EE.EESEB.....ESSSTTEEEEESS- CS
  Ins145_P3_rec 151 yklrseGdnVvvGdkvilkpvsaerfLhvassse.....lrdnkekeVnasne 198
                    +k r eG++++  dkvi+    +++++h++  +      +rd++  eVnas +
     EFC36702.1 309 FKFRTEGEPIRLTDKVIIMNEKTKHSVHISHYKYvrpiiVRDFDRYEVNASSH 361
                    ****************************7644332222245666677777654 PP

>> MIR  MIR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.2   0.00085       2.5      60      90 ..     253     291 ..     210     345 .. 0.69
   2 !   37.3   0.1   8.3e-13   2.5e-09       2     158 ..     382     588 ..     381     601 .. 0.73

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00085
         MIR  60 awrgglikwgkvyRlkHlaTgryLaseeek........k 90 
                 ++ g+ i +g+ + l+H+++g+yL +  ++        k
  EFC36702.1 253 RSWGKPILYGQRIQLYHIKSGMYLNVLRSNadleksslK 291
                 336778888999**************9997666644441 PP

  == domain 2  score: 37.3 bits;  conditional E-value: 8.3e-13
         MIR   2 yLkggdvvRLfHshqdeyltiseqqqkqevflritlypsadaanssr.............aLWeievvqkdawrgglikwgkvyRlkHlaTgryLasee 87 
                 ++kggd++R+ H +    l  +++  ++ +   ++  p++ +  s                L+ ie   +  +rgg + + +++R+kH+ Tg+y+a+++
  EFC36702.1 382 FIKGGDTIRIVHRDLLGALYHPTPSIENTSA-TVVSTPTTSSDESCSlnlngkyssssitTLFQIEGLDS--SRGGIMYYATPCRFKHVSTGKYIAAKQ 477
                 689***********99888666666655533.22222222222222244555666666667*******99..*************************** PP

         MIR  88 ek.................ksplseseddqkevsayglegfegd.....................nDkveifekksttgmksaklv...prdsyvrlqH 145
                  +                 +  +++ + +++ +s+ ++ + + +                     +D++++f + s+++ ++ +      ++s +r++H
  EFC36702.1 478 VEvpdiegnsgslignsnnNTATTTGATNNTATSTNTVSAAR-SgwrnlrrrvkiklklvltdnpRDEASVFYLYSSENSNQFTTSdpiLGQSLLRIKH 575
                 **********99999988533333333333333333333333.358889999999999999999999999998888877776555442268******** PP

         MIR 146 vvtgcwLhstsvk 158
                 + +++wL+++   
  EFC36702.1 576 AQSNTWLRANDLS 588
                 ********98655 PP

>> Ion_trans  Ion transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   16.1  28.2   1.7e-06    0.0051       6     243 ..    2350    2620 ..    2291    2622 .. 0.78
   2 ?   -3.7   0.2       1.8   5.5e+03     202     217 ..    2656    2671 ..    2654    2672 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.7e-06
                  HHHHHHHHHHHHHHHCCCSSSSHHHHC....HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHHCHSHHHHHHHHHHHHHHHHH............H CS
   Ion_trans    6 lfilllillncvflaletyfpedelek....tileilelvftaiftlemllkilalgllikkrYlrdpwnilDflvvlpsllsl............v 86  
                   +++l+ l+  +++ +++++++d ++     +   + +  ++++++    +k+++ g+   +  +  +  ++  l +++++l +             
  EFC36702.1 2350 NLSFLFSLCINIIVLISFHKKYDVFSGnlpiPGQSYGDKGIDGMIITQG-FKWWGVGI---LVIVLGIIQLITTLLLILIYLRFflllnvkkkfelK 2442
                  4555555554455555577777666666677777777888888777775.78888888...333333333333333333333334444655544440 PP

                  HHH...................................HHHHHHHHHHHHGGGGGGHHHCHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans   87 lse...................................esllllsvlrlfrvlrllklisrleglrtlvtalirsvkdllnvlllllvvlfifalig 148 
                    +                                    sl++l v  l+ +l l+ +++ +  l+ +v ++++  k+++++ +l+++ l ++a  +
  EFC36702.1 2443 --KgetwedaktkddfkkkliinilsdkylwwliiyflISLIGLFVTPLVYCLQLFEVVTLSHVLQDIVFSIFENRKKFFLFSILTIFSLTAYAFTV 2537
                  ..0445555556666777778888888888888888888999999*************************************************999 PP

                  HHHHTTSCCCCCCSCCSTSSSTTTSSS.SSSHHHHHHHHHH.HHTTS.SHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans  149 vqlfkgklreknecaktwenpnngntn.Fdnfftallwlfr.lmtte.gwgdilyatldekskvaliyfvifiilgsflllNlliaviadnfqelte 242 
                  + ++             we+ + g+tn ++n + ++ +++  +   e  +++i+++  +    + +++ ++f+++++++ll +l+++i d+f+e +e
  EFC36702.1 2538 FAFK-------------WEQWIIGTTNaCSNTILCFATTINySVRAEaFLENIMDPQPNDV--FRFFMDIVFYFIVVVILLDVLFGLILDSFSERRE 2619
                  8888.............99999999999*************84444436677777777666..******************************9887 PP

                  H CS
   Ion_trans  243 r 243 
                   
  EFC36702.1 2620 A 2620
                  6 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.8
                  HHHHSHHHHHHHHHHH CS
   Ion_trans  202 tldekskvaliyfvif 217 
                   ++e+++++++yf+i+
  EFC36702.1 2656 IMNEHNMWNYVYFLIY 2671
                  6899999******998 PP

>> DNA_pol3_beta_3  DNA polymerase III beta subunit, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1         1   3.1e+03      15      36 ..    1255    1276 ..    1250    1278 .. 0.87
   2 ?   -4.3   0.0       5.4   1.6e+04      61      81 ..    1487    1507 ..    1468    1508 .. 0.65
   3 ?   11.5   1.5   6.6e-05       0.2      52     118 ..    1624    1691 ..    1617    1693 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1
                       EHHHHHHHHHHHHTTSSTSTGE CS
  DNA_pol3_beta_3   15 dlkelkealkRvalladeknrk 36  
                       + kelke l++v++l  +k+rk
       EFC36702.1 1255 QAKELKENLQKVSILISQKSRK 1276
                       5799***********9999986 PP

  == domain 2  score: -4.3 bits;  conditional E-value: 5.4
                       EEEEBEESS-EEEEEEHHHHH CS
  DNA_pol3_beta_3   61 evdvnyeGeeleiafNvsYll 81  
                       + d  ++G++l+  +N  Yll
       EFC36702.1 1487 NNDHLIIGSDLNYHINLLYLL 1507
                       334445599999999999997 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 6.6e-05
                       ETTSEEEEE.EEEEBEESS-EEEEEEHHHHHHHHHHH-SSEEEEEESSTTS-EEEEETTEESEEEEE- CS
  DNA_pol3_beta_3   52 nsevgeaeE.evdvnyeGeeleiafNvsYlldalkaleteevelqltdstkpvllsevedesvkyvil 118 
                       ns+  + eE  + + ++G++ ei  N  Y+  +l  + ++  e+ +++ +k +ll++ ++e++k +i 
       EFC36702.1 1624 NSDETNSEEvFKRAFFNGSDEEIFVNDIYIFKVLLPFIESFFEMVFNKDVKKMLLQKENKEEIKTIIY 1691
                       44445555524566677**********************************************99885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2777 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1553  (0.0866194); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.36u 0.33s 00:00:01.69 Elapsed: 00:00:00.55
# Mc/sec: 15065.84
//
Query:       EFC36703.1  [L=114]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.9e-09   37.2   0.1    3.7e-09   36.8   0.1    1.2  1  PP-binding    Phosphopantetheine attachment site
     0.0062   16.7   0.2     0.0075   16.5   0.2    1.2  1  PP-binding_2  Acyl-carrier


Domain annotation for each model (and alignments):
>> PP-binding  Phosphopantetheine attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.1   4.2e-13   3.7e-09      20      67 .]      59     107 ..      41     107 .. 0.83

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 4.2e-13
  PP-binding  20 pdtdlf.dlGlDSllavellaaleeefgveiplsdlfehptlaelaayl 67 
                  +++l  dlGlDSl+++e+++++e ef +ei++++ f+++++ ++++++
  EFC36703.1  59 GTSHLVkDLGLDSLDSAEIIHEVENEFVLEINDDVAFQLQSVPQIVEFV 107
                 4677887**************************************9986 PP

>> PP-binding_2  Acyl-carrier
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.2   8.4e-07    0.0075      23      87 ..      47     110 ..      36     114 .] 0.77

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 8.4e-07
  PP-binding_2  23 lrkgekvtpsskleelrtredrlwdgldtvefvedveelfdvivsdevadnfetlqeiadlvvae 87 
                   l k +++  +   +    ++    d+ld+ e++ +ve+ f + ++d+va +++++ +i ++v  e
    EFC36703.1  47 LTKHDNIKTTPTGTSHLVKD-LGLDSLDSAEIIHEVENEFVLEINDDVAFQLQSVPQIVEFVYKE 110
                   55555554444444444443.4469************************************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       457  (0.0254894); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.42u 0.25s 00:00:00.67 Elapsed: 00:00:00.44
# Mc/sec: 779.02
//
Query:       EFC36704.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0044   17.2   0.5      0.012   15.8   0.5    1.8  1  HALZ         Homeobox associated leucine zipper
  ------ inclusion threshold ------
       0.78   10.2  16.1       0.68   10.4   0.5    2.8  2  DUF4600      Domain of unknown function (DUF4600)


Domain annotation for each model (and alignments):
>> HALZ  Homeobox associated leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.5   1.3e-06     0.012      21      40 ..     278     297 ..     275     300 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.3e-06
        HALZ  21 ydsLkkenekLkaelqeLke 40 
                 ++ L++en++Lk+++qeL++
  EFC36704.1 278 VETLLEENRQLKKQVQELTG 297
                 699***************97 PP

>> DUF4600  Domain of unknown function (DUF4600)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   9.3     0.014   1.2e+02       7     110 ..     137     257 ..     131     266 .. 0.70
   2 ?   10.4   0.5   7.6e-05      0.68      10      45 ..     279     314 ..     272     332 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.014
     DUF4600   7 trYetqlelNdqLekqiailkeklekirgnpsdrlasirv................leklteeelnqllkqLekekkslenqlkdlelr.leqEsKayh 88 
                 + Y   +e+ +++ k  +i+++  e   +++ ++   ++                 + kl+ ++++ ++ +Le + k+ e  l + +lr  eqE K + 
  EFC36704.1 137 RAYRMMVEMANEIIKLTNIIQRDFEVEYSKQREQNVHLNKvceewnnyfgktvddkYSKLSPRDIRLIIDKLEMDVKKYEDTLNEERLRhYEQERKLHL 235
                 55666666666666666666666666555555544444446667777777777777*******************************995699999998 PP

     DUF4600  89 kandeRkaylaelaqlsatqev 110
                  +n++  a   ++ ++  + ++
  EFC36704.1 236 MINEHHEASRKSIRNMMKQTSA 257
                 8888655444444444433333 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 7.6e-05
     DUF4600  10 etqlelNdqLekqiailkeklekirgnpsdrlasir 45 
                 et+le N qL+kq++ l  + +k r ++++  +s  
  EFC36704.1 279 ETLLEENRQLKKQVQELTGSTSKYRTSHHNMTSSST 314
                 9************************77777666544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2552  (0.142339); expected 358.6 (0.02)
Passed bias filter:                      600  (0.0334653); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.48
# Mc/sec: 2101.95
//
Query:       EFC36705.1  [L=557]
Description: rabGTPase-activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.2e-41  141.0  11.7    3.4e-23   82.5   0.0    2.9  3  RabGAP-TBC  Rab-GTPase-TBC domain
  ------ inclusion threshold ------
      0.019   13.6  12.3       0.03   12.9  12.3    1.3  1  Macoilin    Macoilin family
      0.076   13.6   8.8       0.14   12.8   8.8    1.4  1  SOBP        Sine oculis-binding protein


Domain annotation for each model (and alignments):
>> RabGAP-TBC  Rab-GTPase-TBC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   1.2      0.65   3.9e+03      30      50 ..     177     197 ..     162     215 .. 0.45
   2 !   82.5   0.0   5.6e-27   3.4e-23       3     125 ..     235     354 ..     233     358 .. 0.83
   3 !   64.8   1.8   1.4e-21   8.6e-18     117     215 .]     405     504 ..     394     504 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.65
  RabGAP-TBC  30 ksekeksklekseeskelsqI 50 
                  ++++k+k++k++e+ +++ I
  EFC36705.1 177 IEQSMKEKERKRKEKAKEQLI 197
                 222222222222222222222 PP

  == domain 2  score: 82.5 bits;  conditional E-value: 5.6e-27
  RabGAP-TBC   3 lRgevWklllgyepevkrlkksekkqeksekeksklekseeskelsqIkkDvprtfp.es.esfknkqgqnqLeriLkaysiynpevgYcqGmndivap 99 
                 lR+++W   lg+e +     ++  k+++    ++  +++++ + +  I+ D++rtfp  + ++  +++  +  + iL +ys+ +p++gY+qGm++ va+
  EFC36705.1 235 LRSKMWVASLGNELQITPGLYEILKDKT----NQPSTMERQCSSIDLISVDLSRTFPaLQfFQYPDGPYYQPFKTILECYSKFRPDIGYVQGMSYMVAT 329
                 8***********8866666665555544....4455555555569************733588889999****************************** PP

  RabGAP-TBC 100 lllvsldeeeaFwcfvsLlekyklrd 125
                 ll +++de++aF cf++Ll++ k+++
  EFC36705.1 330 LL-LYMDEYDAFVCFCNLLHRSKCNS 354
                 **.999*************8777765 PP

  == domain 3  score: 64.8 bits;  conditional E-value: 1.4e-21
  RabGAP-TBC 117 Llekyklrdlytsslpglkrklkvleellkkkdpklykhl.keegldlelfaikwfltlflrefpletvlrlwD.lllegekfvllrvalailklleee 213
                 L +++++  ++t +++ + + +k ++ ll++++ +lykhl  ++g+++ +++i+wfltlf++++pl++v+r+wD +l++g   +++++++ il ++++e
  EFC36705.1 405 LYTSNHFIPFFTMNTDYIDKNVKFVRILLREHHAQLYKHLvVDLGVEFAVIIIDWFLTLFSKSLPLDVVARIWDgYLVHGR-LYMYSCTMGILIYYQKE 502
                 5567788899*****************************9799*******************************9999998.88999*********999 PP

  RabGAP-TBC 214 ll 215
                 ll
  EFC36705.1 503 LL 504
                 86 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9  12.3   5.1e-06      0.03     245     369 ..      28     179 ..       8     277 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 5.1e-06
    Macoilin 245 dsslklpeleyrekkksakssrsdskkkhehn...esvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskkasagsag 340
                 d   +l e+e + +++ + +++ +s  +++h+   ++vd+k  e++++ n+ ++ + +    ++++  + +++s+++  s s s + ++s ++s++ ++
  EFC36705.1  28 DDDDNLDEIELNYQSSLTLDNK-ESVLHEAHSepsSNVDEKEVEEHHHLNNNNNYQDEIVPPPSEQRAIFTSSSTSDIRSRSDSIT-SQSTHSSNSETS 124
                 4555666776666655555653.344444444466788999999999999988888888866777767766666666665555554.444444454556 PP

    Macoilin 341 ssnssskkhsessksvtsssssknskkq...........................k 369
                 ss s  + h++++ s +ssss  + k+                            +
  EFC36705.1 125 SSLSIGAIHQTNNLSSSSSSS-VEPKRSslrtpengditidmiqqniklqkqlieQ 179
                 666667777777666665553.3334442333444444333333333333333321 PP

>> SOBP  Sine oculis-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   8.8   2.3e-05      0.14      45     174 ..      72     202 ..      65     281 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.3e-05
        SOBP  45 qahLdmnphlkeksksaGseaqLitPdlwlsncrsrsaspaskrsesvspepsksaspssspt.ssnsskplisvassskllaeksqepaslveaplep 142
                 + hL++n + +++     se++ i   +  s++rsrs+s +s++++s++ e s+s s+ +  + ++ ss++  sv++++++l + ++   ++   ++++
  EFC36705.1  72 HHHLNNNNNYQDEIVPPPSEQRAIFTSSSTSDIRSRSDSITSQSTHSSNSETSSSLSIGAIHQtNNLSSSSSSSVEPKRSSLRTPENGDITIDMIQQNI 170
                 55899999999999998889999999999**************99999999887777776665255567777888888888888888888888889999 PP

        SOBP 143 kkqrkkkpglrkpkqvkagsskssetkagllq 174
                 k q++  ++++k+k++k +++++++  +++l+
  EFC36705.1 171 KLQKQLIEQSMKEKERKRKEKAKEQLIQSNLD 202
                 99999988888888888665555555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (557 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1692  (0.0943722); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.47
# Mc/sec: 3539.14
//
Query:       EFC36706.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.1e-43  149.7   0.0    1.3e-43  149.4   0.0    1.0  1  Trypsin    Trypsin
    2.6e-06   28.4   0.0    4.4e-06   27.7   0.0    1.4  1  Trypsin_2  Trypsin-like peptidase domain
  ------ inclusion threshold ------
      0.033   13.8   0.0      0.056   13.0   0.0    1.3  1  DUF316     Chymotrypsin family Peptidase-S1


Domain annotation for each model (and alignments):
>> Trypsin  Trypsin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  149.4   0.0   2.2e-47   1.3e-43       4     221 .]      36     267 ..      33     267 .. 0.93

  Alignments for each domain:
  == domain 1  score: 149.4 bits;  conditional E-value: 2.2e-47
                 SEETTTTSSTTEEEEEETTC....EEEEEEEEEETTEEEEEGGGTTT......GGGEEEEESESBTTSCTTTEEEEEEEEEEEETTEBTTTTTTTEEEE CS
     Trypsin   4 geeaqkgsfpwqvslsvksg....khlCgGslisenwvlTAaHCvsn......asdvkvvlgehnlkksegkeqklkvekvivhpnynpstldnDiall 92 
                 g+ +   +fp++vs++++      +h+CgGs+is++ +lTAaHC+++       ++++++ g+++l++++    ++ +++ ++hpn++ +t  nDia++
  EFC36706.1  36 GKISGNVEFPFMVSIQYRFDsgefNHFCGGSIISKQHILTAAHCFYSkgelisIERLRIRYGSSDLSSNDL--LEIIISDLFIHPNFTLETNRNDIAIV 132
                 555555689********877899*************************99999999999***988888888..89999********************* PP

                 EESSSSTSBSSBHCCBBCSTTHTTSTTTEEEEEESSBSSTSS..BSSBEEEEEEEEEEHHHHHHH.TTTTSTTTEEEEESTTSSSBCTTTTTTSEEEET CS
     Trypsin  93 klkepvklgdtvrpiclpaassslpvgttclvsGwgrtkekg..ksdtlqevevpvvsretcksa.ykgkvtenmlcagakeggkdacqGDSGGPlvcs 188
                 k  +++++++++  i+  + s+++p+g + +++Gwg  +e++  +s++l+ +++p++s  +c+   + +  ++n+lcag+  gg+d+c GDSGGPl++ 
  EFC36706.1 133 KTINELEINNSTTRIAFLE-SETIPNGFKLIAVGWGFYNEQQtsFSNKLRRARIPLTSLLNCNGMgL-RANSPNQLCAGD-GGGADTCIGDSGGPLFRF 228
                 *******************.7889*************8888889********************954.4469********.577*************** PP

                 TT....EEEEEEEEE..SSSSCTTSEEEEEEGGGGHHHH CS
     Trypsin 189 dg....elvGivswg..kgcakgnrpgvytkvssyldwi 221
                 +g     lvGi+s+g   +c++ n  +vyt++s+y+++i
  EFC36706.1 229 EGlfdfALVGIISYGrdVKCGSMNSLTVYTNISHYNPFI 267
                 ***************999******************998 PP

>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.0   7.4e-10   4.4e-06       3     145 ..      65     230 ..      63     239 .. 0.72

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 7.4e-10
   Trypsin_2   3 GflvgsdglilTnaHvv.................dsadgaavkaikkkveeagadgrevpakvvaadpelDlAllkv..ssderaglpplplgpsealk 82 
                 G ++++++ ilT+aH++                 +s+ +++        e++ +d   +p   ++++ + D+A++k   + + +++   + + +se+++
  EFC36706.1  65 GSIISKQH-ILTAAHCFyskgelisierlrirygSSDLSSN-----DLLEIIISDLFIHPNFTLETN-RNDIAIVKTinELEINNSTTRIAFLESETIP 156
                 78999**9.********776666666666666553333333.....477889999999999999999.99*******8755555556666677788899 PP

   Trypsin_2  83 ggepvyvvGyplggeksgsvssGivsgvve.......sesaasgegesfl......qtdaatspGsSGGplfdsdG 145
                 +g ++++vG +  +e ++s+s+   ++  +       +    + ++++ l       +d+ +  G SGGplf+ +G
  EFC36706.1 157 NGFKLIAVGWGFYNEQQTSFSNKLRRARIPltsllncNGMGLRANSPNQLcagdggGADTCI--GDSGGPLFRFEG 230
                 999*******8777776544444333333377777773333333444444577888999999..*********998 PP

>> DUF316  Chymotrypsin family Peptidase-S1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   9.4e-06     0.056      48      91 ..      39      83 ..      20     100 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 9.4e-06
      DUF316 48 aekseneWlvlvafk.ngnekkelapatvISsrHiltssrvilts 91
                + + e +++v+++ + +  e + +  +++IS+ Hilt ++ ++++
  EFC36706.1 39 SGNVEFPFMVSIQYRfDSGEFNHFCGGSIISKQHILTAAHCFYSK 83
                55555555555544313333455559****************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       415  (0.0231469); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.43u 0.25s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 2271.81
//
Query:       EFC36707.1  [L=155]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.011   15.6   0.0      0.017   15.0   0.0    1.3  1  F-box       F-box domain
      0.032   14.6   0.3       0.16   12.3   0.0    2.3  3  PRANC       PRANC domain
      0.086   12.7   0.8       0.17   11.8   0.6    1.6  2  Triabin     Triabin
       0.12   12.0   0.5       0.15   11.6   0.5    1.2  1  PEPCK_N     Phosphoenolpyruvate carboxykinase N-terminal doma
       0.15   12.0   0.0       0.24   11.3   0.0    1.3  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.0   4.9e-06     0.017       2      39 ..       5      42 ..       4      50 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 4.9e-06
                HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTT CS
       F-box  2 tlsrLPsevlrhILerLplsdllalrrVSkgwrilids 39
                ++ +LP  v ++I+ +L+ ++l    + Sk+  + +d+
  EFC36707.1  5 SWHDLPQVVQLEIFTFLSIKHLGKVLSLSKTIQQQLDE 42
                89*******************99999999988887776 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   4.6e-05      0.16      69      95 ..       3      29 ..       1      31 [. 0.90
   2 ?   -1.7   0.0         1   3.7e+03      56      77 ..      30      52 ..      27      59 .. 0.74
   3 ?   -0.4   0.1      0.42   1.5e+03      13      13 ..      96      96 ..      53     128 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.6e-05
       PRANC 69 kslWnlLPiEIkykIleyLndkdLknl 95
                +s+W+ LP  ++ +I+++L+ k+L + 
  EFC36707.1  3 ESSWHDLPQVVQLEIFTFLSIKHLGKV 29
                589*******************99765 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1
       PRANC 56 ekaievlnnicsk.kslWnlLPi 77
                 ++++++++ +++ ++ W+ L +
  EFC36707.1 30 LSLSKTIQQQLDEsEYFWQKLSV 52
                56677777777777888888766 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.42
       PRANC 13 k 13
                k
  EFC36707.1 96 K 96
                1 PP

>> Triabin  Triabin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.6   4.7e-05      0.17      13      99 ..      32     114 ..      26     143 .. 0.84
   2 ?   -1.4   0.0      0.52   1.9e+03       9      25 ..     131     147 ..     123     150 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.7e-05
                 GG----SS--HHHHSSSEEEEESSSS---SEEEEEEE-SSS---EEEE.EES-T.TS-TT-EEEEEE-S--TT-EEEEEEETT---E CS
     Triabin  13 lkekavddFdleefFkgkwyltHardvtkpkvCqkykttknkGtttilseikfnGksesevkctlakvegkkGqysfeCevsdgkkf 99 
                 l + ++++ d  e+F +k+ +  ar    p++ ++ k+  n+ t + l + k++   + e+ ++   ++ ++ q+++  e    kk+
  EFC36707.1  32 LSKTIQQQLDESEYFWQKLSVNYARVLDDPNIMEQTKALANDQTEKNL-HEKYS--NHFELLMKAKDKKKVELQTKVMVEKRR-KKL 114
                 66789999*********************************9777777.77888..678888888888888888888887766.555 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.52
                 T--GGG----SS--HHH CS
     Triabin   9 gckelkekavddFdlee 25 
                 g ++ +ek  ++Fdle+
  EFC36707.1 131 GSEKKEEKKEENFDLEK 147
                 66677888889999886 PP

>> PEPCK_N  Phosphoenolpyruvate carboxykinase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.5   4.3e-05      0.15      29      77 ..      67     116 ..      58     149 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.3e-05
                 HHHHHHTTSEEE-.TTSBS-EEE---TTSSS--GGGEEEE-SSHHHH-SS CS
     PEPCK_N  29 lkelvekgelikl.ekypnsylarsdpkDvARvesrTfictekeedagpl 77 
                 +k l +++++++l eky+n++    + kD  +ve +T +++ek+++  +l
  EFC36707.1  67 TKALANDQTEKNLhEKYSNHFELLMKAKDKKKVELQTKVMVEKRRKKLEL 116
                 56677888999999***************************999988333 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   6.6e-05      0.24       1      46 [.       6      51 ..       6      53 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6.6e-05
  F-box-like  1 isrLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrlv 46
                + +LP  + l+IF +L+ + L  +   ++  ++      ++W++l+
  EFC36707.1  6 WHDLPQVVQLEIFTFLSIKHLGKVLSLSKTIQQQLDESEYFWQKLS 51
                679********************99999999999988889999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (155 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2218  (0.12371); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 982.12
//
Query:       EFC36708.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       539  (0.030063); expected 358.6 (0.02)
Passed bias filter:                      313  (0.0174578); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.31u 0.19s 00:00:00.50 Elapsed: 00:00:00.33
# Mc/sec: 1071.49
//
Query:       EFC36709.1  [L=147]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.076   13.5   0.0       0.11   13.0   0.0    1.3  1  Phospholip_A2_1  Phospholipase A2


Domain annotation for each model (and alignments):
>> Phospholip_A2_1  Phospholipase A2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   5.9e-06      0.11      15      47 ..      59      93 ..      45     121 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 5.9e-06
                     HHHHCTTBTTTSSSS--S..S-SSHHHHHHHHHHH CS
  Phospholip_A2_1 15 allkynsYGcyCglggkg..kpvDevDrcCqahdk 47
                     +++k   YG y g g +    p+D++D +C  hdk
       EFC36709.1 59 EVTKLFWYGNYGGPGTNStlLPIDALDAACLFHDK 93
                     566777899999776555227************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (147 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       388  (0.0216409); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.36u 0.20s 00:00:00.56 Elapsed: 00:00:00.36
# Mc/sec: 1218.35
//
Query:       EFC36710.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.2e-20   71.6   1.3    8.2e-20   70.7   0.1    2.0  2  DnaJ             DnaJ domain
     0.0094   15.0   1.5      0.011   14.8   1.5    1.1  1  Corona_nucleoca  Coronavirus nucleocapsid protein
  ------ inclusion threshold ------
      0.013   16.6   1.9       0.03   15.4   1.9    1.6  1  MRI              Modulator of retrovirus infection
       0.92    8.0  10.0       0.95    7.9  10.0    1.1  1  Macoilin         Macoilin family
        9.1    7.0  12.0          8    7.2  10.9    1.4  1  NAM-associated   No apical meristem-associated C-terminal dom


Domain annotation for each model (and alignments):
>> DnaJ  DnaJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1      0.66   2.4e+03      41      51 ..      34      44 ..      16      64 .. 0.63
   2 !   70.7   0.1   2.3e-23   8.2e-20       1      59 [.     138     195 ..     138     197 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.66
                HHHHHHHHHHH CS
        DnaJ 41 ekFkeineAye 51
                ++ + in+A +
  EFC36710.1 34 KAIRLINKAKK 44
                44444555543 PP

  == domain 2  score: 70.7 bits;  conditional E-value: 2.3e-23
                 HHHHHHTSSTTG-HHHHHHHHHHHHHHHSTTTSCCHHHHHHHHHHHHHHHHHHTSHHHH CS
        DnaJ   1 dyYeiLgvskdasedeIkkaYrklalkyHPDknpkdpeaeekFkeineAyevLsdpekR 59 
                 dyY++Lgv+k+a++deIkkaYrklalk+HPD+n   pea+e+Fk i  Ay  L   +k+
  EFC36710.1 138 DYYKVLGVDKKATKDEIKKAYRKLALKFHPDRN-TVPEATEAFKIIGGAYIKLGWTNKK 195
                 8********************************.999*************888766665 PP

>> Corona_nucleoca  Coronavirus nucleocapsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   1.5     3e-06     0.011     167     234 ..      83     158 ..      41     179 .. 0.66

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 3e-06
                      XXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......XXXXXXXXXXSXCGCGS CS
  Corona_nucleoca 167 rsraasrsgsr..srsrsrnrarsssrgrspastakndveeeiaalvLekLgk......dkgqqkqvtkksakear 234
                       s+a+s s+s   s srs+n+  sss g++  +  ++   +e    vL+ ++         g +k+ tk   k+a 
       EFC36710.1  83 SSAASSSSSSTtpSSSRSNNQESSSSSGNESGNDSSPTYTKEQKDEVLKIISYkddyykVLGVDKKATKDEIKKAY 158
                      34444444443337888899999***99999998888777666666666555422112233444444444444443 PP

>> MRI  Modulator of retrovirus infection
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   1.9   8.3e-06      0.03      12      72 ..      64     123 ..      60     138 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 8.3e-06
         MRI  12 DvALgiLiEarkqekpleqlalagadkpelspacsespssssgsrseeedsgkdapapgls 72 
                 D  Lg ++ +++q  p  q + a +    ++p++s+s +  s+s+  +++sg+d+ ++  +
  EFC36710.1  64 DDLLGYVLTKKHQHGPHHQSSAASSSSSSTTPSSSRSNNQESSSS-SGNESGNDSSPTYTK 123
                 666898999999999********9999999999999988886555.555556665544333 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9  10.0   0.00026      0.95     269     384 ..      42     155 ..       2     206 .. 0.59

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00026
    Macoilin 269 skkkhehnesvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskkasagsagssnssskkhsessksvtsssssknskk 367
                 +kk +e+ +  ++  +++    + +    l+k++++g +++  + +s++s++++sss+sn++++++s+g+ +   ss+   +e++++v +  s k++  
  EFC36710.1  42 AKKLYEDVNPSHHGFDKNLKSIDDLLGYVLTKKHQHGPHHQSSAASSSSSSTTPSSSRSNNQESSSSSGNESGNDSSPTYTKEQKDEVLKIISYKDDYY 140
                 333333334334433333333334444555566666777777777777777777777766666655665555566666666666677777666666665 PP

    Macoilin 368 qklpaGkssaalkdaae 384
                 + l++ k  +a+kd+++
  EFC36710.1 141 KVLGVDK--KATKDEIK 155
                 5554443..33444333 PP

>> NAM-associated  No apical meristem-associated C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2  10.9    0.0022         8      29     117 ..      77     159 ..      54     182 .. 0.62

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0022
  NAM-associated  29 rkpkssassspatsssestdeedssesssesseesaadsestsssrlkRPiGkkkaKekrke.askdeealeklasaqkkiakkskekke 117
                      +p+ ++s+ +++sss       ++ sss s+++++++s++ +s++   P+ +k+ K+   +  s++++  + l   +k+ +++ k++ +
      EFC36710.1  77 HGPHHQSSAASSSSSS-------TTPSSSRSNNQESSSSSGNESGNDSSPTYTKEQKDEVLKiISYKDDYYKVLGVDKKATKDEIKKAYR 159
                     2333333333333333.......2234444555556667777777788888888888777776555556666665555555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1845  (0.102906); expected 358.6 (0.02)
Passed bias filter:                      818  (0.0456244); expected 358.6 (0.02)
Passed Vit filter:                       125  (0.00697194); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 1185.03
//
Query:       EFC36711.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.9e-15   54.7   0.2    1.6e-14   53.5   0.2    1.7  1  Homeobox_KN  Homeobox KN domain
    3.6e-07   29.9   0.9    9.7e-07   28.5   0.9    1.8  1  Homeodomain  Homeodomain
  ------ inclusion threshold ------
       0.71   10.1   4.6        1.3    9.2   4.5    1.5  1  SAP18        Sin3 associated polypeptide p18 (SAP18)


Domain annotation for each model (and alignments):
>> Homeobox_KN  Homeobox KN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.5   0.2   2.7e-18   1.6e-14       1      40 []     151     190 ..     151     190 .. 0.99

  Alignments for each domain:
  == domain 1  score: 53.5 bits;  conditional E-value: 2.7e-18
  Homeobox_KN   1 WflahlhnPYPseedKeeLlkeTglsvkqitnWFINaRrR 40 
                  W+ +h ++PYPs+e+K+eLl++  +++ q+ +WF+N R+R
   EFC36711.1 151 WLQNHSDYPYPSDEEKDELLERVSMTKDQLETWFVNNRKR 190
                  ***************************************9 PP

>> Homeodomain  Homeodomain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5   0.9   1.6e-10   9.7e-07       1      54 [.     134     190 ..     134     191 .. 0.92

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 1.6e-10
                  ST-SSSS-HHHHHHHHHHHHH...SSS-SHHHHHHHHHHHTS-HHHHHHHHHHHHHH CS
  Homeodomain   1 rrkRttftkeqleeLeklFee...nrypsaeereeLAkklgLeerqVkvWFqNrRak 54 
                  +rkR +f+k+  e L +  ++    +yps ee+ eL +++ ++++q  +WF N R +
   EFC36711.1 134 KRKRSNFSKKDKELLIEWLQNhsdYPYPSDEEKDELLERVSMTKDQLETWFVNNRKR 190
                  79*************99998544589****************************987 PP

>> SAP18  Sin3 associated polypeptide p18 (SAP18)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   4.5   0.00021       1.3      17     115 ..      40     146 ..      36     179 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00021
       SAP18  17 ktgsfhrldeFsssgklps...delqiytWkdctLrELaqllksalpsllpspavgtrlsFrlvypdtrrgryaskdlGsvvsgkkgseaeddseeeee 112
                 +++++h+ ++F +s++          + +  ++tL+++ +   +  +++l+s+ +  + +F+  +  ++rgr++s d  s++  + + ++++ s+++++
  EFC36711.1  40 NNNNHHHNTQFLKSNQSSIdamFRKLMEAKFSSTLSDIESNFNQF-DNNLSSTLKMIESDFKSLFETKKRGRIISSDTSSTMCDQDDYSTASGSKKRKR 137
                 567777777777544333322211224455689**********99.8888888888**********9989*********99999999977766533333 PP

       SAP18 113 ke......r 115
                 ++      +
  EFC36711.1 138 SNfskkdkE 146
                 333333330 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1581  (0.0881812); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1435.16
//
Query:       EFC36712.1  [L=346]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-23   83.7   1.2    2.1e-22   79.6   0.7    2.4  2  adh_short      short chain dehydrogenase
    4.5e-13   49.3   0.0    8.3e-13   48.4   0.0    1.4  1  adh_short_C2   Enoyl-(Acyl carrier protein) reductase
     0.0015   18.0   0.1      0.002   17.6   0.1    1.1  1  GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
  ------ inclusion threshold ------
      0.053   13.4   0.0        0.1   12.5   0.0    1.6  1  KR             KR domain


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.6   0.7   4.6e-26   2.1e-22       1     141 [.      46     195 ..      46     201 .. 0.83
   2 ?    2.0   0.0     0.026   1.2e+02     143     170 ..     214     241 ..     208     267 .. 0.79

  Alignments for each domain:
  == domain 1  score: 79.6 bits;  conditional E-value: 4.6e-26
                 SEEEEESTTS.HHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT...........TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---S CS
   adh_short   1 kvvlvtGass.GIGraiakelakeGakvvvvdrseekleevakelkee...........gakalaiqvDvtdreevealvekavkklgkldvLvnNAGi 87 
                 +v+++tG s+ GIG++++k l++++ ++++  r  +k e++  e+ e+           + +++++q+D++d ++v+ + +++++k+++ d+L+nNAGi
  EFC36712.1  46 NVIVITGVSKnGIGYETCKSLLAKNGTIIIGVRDLKKGEATRREILEQvaleennqnnsKGNIYVMQLDLNDLDSVKHFADEIKEKFKRCDILINNAGI 144
                 699****9855******************976666666666555543333322233445566************************************* PP

                 S--SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTS CS
   adh_short  88 tgsgpfselseeewervievNltgvflltravlpamlkqssGrIvnvsSvagkv 141
                   s+  + ls++++e  + +N  g fllt +++++ lk s+Gr+++v+S a ++
  EFC36712.1 145 --SNVPHALSKQNVEIHFGTNHLGHFLLTNLLIDQ-LKDSKGRVITVASRAHEN 195
                 ..56677899999**********************.669**********99766 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.026
                 -TTBHHHHHHHHHHHHHHHHHHHHHGGG CS
   adh_short 143 vagvaaYsAsKaavagltrslakelapt 170
                 v++   Y+ sK+a + ++++l + la++
  EFC36712.1 214 VPSHYLYARSKFANVLFSKKLDRILAEQ 241
                 567778**************99888765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.4   0.0   1.9e-16   8.3e-13       1     133 [.      52     195 ..      52     206 .. 0.83

  Alignments for each domain:
  == domain 1  score: 48.4 bits;  conditional E-value: 1.9e-16
                   TTT.TSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTT........SE..E..EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGC CS
  adh_short_C2   1 Gaa.sgIGraiAkalaeeGaevvltdlneea.kkrveelaeelg........ae..v..lecDVtdeeqvealveevvekfgklDilvnnagiapkl 83 
                   G+  +gIG+++ k+l ++  ++++  ++ ++ +++ +e+ e++         ++  +  +++D +d ++v+++++e++ekf++ Dil+nnagi++  
    EFC36712.1  52 GVSkNGIGYETCKSLLAKNGTIIIGVRDLKKgEATRREILEQVAleennqnnSKgnIyvMQLDLNDLDSVKHFADEIKEKFKRCDILINNAGISNV- 147
                   78889********9999999999888887776666666666654433343332245257************************************9. PP

                   SS-GGGH-HHHHHHHHHHHTHHHHHHHHHHHHHCTSC.CEEEEEEEGGGTS CS
  adh_short_C2  84 kgpfletsreefdraldvnlyslfllakaalplmkeg.gsivnlssvgaer 133
                       + +s+++++  + +n  + fll++ ++  +k++ g++++++s + e 
    EFC36712.1 148 ---PHALSKQNVEIHFGTNHLGHFLLTNLLIDQLKDSkGRVITVASRAHEN 195
                   ...6899*************************777666*******987765 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.1   4.4e-07     0.002       9     160 ..      58     227 ..      49     236 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 4.4e-07
                    HHHHHHHHHHHCT-CCEEEEEEESS-TTHHHH.....HCTTT...TTGCCEEEEE--TT-HHHHHHHHHHH.....T-SEEEE--S---HHH..HT CS
  GDP_Man_Dehyd   9 iGsylaelLlekgyevhgivrrsssfntgrie.....hlakdpkeeleenlklhkgDltDssslerllaev.....qpdevynLAAqshVdv..sf 92 
                    iG  +++ Ll+k+ ++++ vr+ ++ +++r e     +l+++++++ ++n+ +++ Dl+D +s+++  +e+     ++d  +n A+ s V+   s 
     EFC36712.1  58 IGYETCKSLLAKNGTIIIGVRDLKKGEATRREileqvALEENNQNNSKGNIYVMQLDLNDLDSVKHFADEIkekfkRCDILINNAGISNVPHalSK 153
                    89999999999988887778887777777777333445556677777789****************999987767789************872255 PP

                    TSHHHHHHHHTHHHHHHHHHHHHCT..TTSEEEEEEE...GGGG-S-S..SSSB-TTS----.-SHHHHHHHHH CS
  GDP_Man_Dehyd  93 ekPeytaevnvlGtlrLLeairalglekkvrfyqaSt...sEvYGkvq..evpqtEttpfyP.rsPYaaaKlya 160
                    ++ e  + +n lG + L ++  +   ++k r++ + +      YGk+   +  ++ t ++ P +  Ya +K + 
     EFC36712.1 154 QNVEIHFGTNHLGHFLLTNLLIDQLKDSKGRVITVASrahENYYGKTFklDEVYNNTCHYVPsHYLYARSKFAN 227
                    78889999*******99998877655667777777663334689*99423555677777777366899999876 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   2.3e-05       0.1       4      94 ..      49     147 ..      46     180 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.3e-05
                 EEETT.TSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHH......HHHHHHHTT-.....EEEE----TT-HHHHHHHHHHHHHHSS---EEEE--- CS
          KR   4 litGG.lGgLGlelarwlaekgarhlvllsRsaaadedska......liaelealga.....evevvaaDvsdkdavealleeikaeeppikGvihaAg 90 
                 +itG    g+G e+++ l++k   ++++  R+ ++ e+ ++       ++e +         ++ v+++D+ d d+v++  +eik+++++    i+ Ag
  EFC36712.1  49 VITGVsKNGIGYETCKSLLAKNG-TIIIGVRDLKKGEATRReileqvALEENN---QnnskgNIYVMQLDLNDLDSVKHFADEIKEKFKRCDILINNAG 143
                 67775146999999999998865.56666666544433333222222222222...2455679*****************************9999999 PP

                 ---- CS
          KR  91 vlrd 94 
                 +++ 
  EFC36712.1 144 ISNV 147
                 9874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2098.19
//
Query:       EFC36713.1  [L=427]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.8e-75  247.1  19.4      5e-17   61.4   1.3    7.1  7  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.3   0.4   1.1e-19   1.9e-15       1      49 []      42      90 ..      42      90 .. 0.99
   2 !   61.4   1.3   2.8e-21     5e-17       1      49 []     143     191 ..     143     191 .. 0.99
   3 !   61.3   0.0   2.9e-21   5.2e-17       3      46 ..     170     213 ..     170     216 .. 0.96
   4 !   44.6   0.1   4.6e-16   8.3e-12       1      49 []     193     241 ..     193     241 .. 0.99
   5 !   37.5   0.2   7.7e-14   1.4e-09       1      48 [.     218     265 ..     218     265 .. 0.98
   6 !   32.7   0.0   2.5e-12   4.5e-08       1      45 [.     243     287 ..     243     320 .. 0.95
   7 !    5.7   0.1   0.00069        12       2      39 ..     364     404 ..     363     414 .. 0.75

  Alignments for each domain:
  == domain 1  score: 56.3 bits;  conditional E-value: 1.1e-19
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                +rE+vl+++k+ng++++y++ +L+ D+ei+l+ +k++++a++++++eL+
  EFC36713.1 42 NREVVLKLCKHNGMVIQYVNAKLRFDREIILETLKNCPSAIEFIPNELK 90
                8**********************************************97 PP

  == domain 2  score: 61.4 bits;  conditional E-value: 2.8e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++E+++e++k ng +lk++s eLknDke+vl+Avk++g a++yaseeL+
  EFC36713.1 143 NKELMMEYIKENGDYLKFVSMELKNDKELVLQAVKNSGLAIYYASEELK 191
                 79*********************************************97 PP

  == domain 3  score: 61.3 bits;  conditional E-value: 2.9e-21
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 E+vl+avk+ g+a++y+seeLk+D+eivl+Avkq+gta++y+ +
  EFC36713.1 170 ELVLQAVKNSGLAIYYASEELKRDREIVLEAVKQDGTAYNYVAP 213
                 89***************************************966 PP

  == domain 4  score: 44.6 bits;  conditional E-value: 4.6e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivleavk++g a++y+ + +++Dkei+  A+ +++++++ ase+L+
  EFC36713.1 193 DREIVLEAVKQDGTAYNYVAPHFSSDKEIISLALCRDSNFFNLASESLK 241
                 9*********************************************997 PP

  == domain 5  score: 37.5 bits;  conditional E-value: 7.7e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D+Ei+  a+ ++++ ++ +se+LknD e+v+ +v   g +l++++e L
  EFC36713.1 218 DKEIISLALCRDSNFFNLASESLKNDYEFVMDIVSTRGMILKFLPETL 265
                 9********************************************976 PP

  == domain 6  score: 32.7 bits;  conditional E-value: 2.5e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 D E+v+ +v++ g++lk+l+e L n++ i l+A+ +ng ++++ +
  EFC36713.1 243 DYEFVMDIVSTRGMILKFLPETLMNNRTINLAAILNNGRVIEFSP 287
                 569************************************999976 PP

  == domain 7  score: 5.7 bits;  conditional E-value: 0.00069
     DUF4116   2 rEivleavkkngsalky..lseeLknDk.eivlkAvkqngt 39 
                 +++vl+ ++ +gs+++y  +   + +Dk    ++Avk+ng+
  EFC36713.1 364 EQLVLKFIRMDGSVIEYhnIKRFIHSDKsKYFIEAVKSNGF 404
                 67999999999999999444433455776778888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (427 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       808  (0.0450667); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 2700.56
//
Query:       EFC36714.1  [L=518]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.4e-19   68.3   0.0    4.6e-18   65.9   0.0    2.2  1  AAA              ATPase family associated with various cellul
      8e-08   32.5   0.6    4.7e-05   23.5   0.2    2.3  2  BCS1_N           BCS1 N terminal
    0.00043   20.3   0.0      0.001   19.1   0.0    1.6  1  AAA_5            AAA domain (dynein-related subfamily)
     0.0016   18.9   0.0      0.003   18.0   0.0    1.4  1  AAA_16           AAA ATPase domain
     0.0017   18.7   0.2      0.018   15.4   0.2    2.7  1  RNA_helicase     RNA helicase
     0.0042   16.9   0.0     0.0078   16.0   0.0    1.3  1  RuvB_N           Holliday junction DNA helicase RuvB P-loop d
     0.0077   16.2   0.2      0.025   14.5   0.0    1.9  2  ATPase_2         ATPase domain predominantly from Archaea
  ------ inclusion threshold ------
      0.018   14.6   0.0      0.035   13.6   0.0    1.5  1  AAA_7            P-loop containing dynein motor region
       0.02   15.0   0.0      0.052   13.6   0.0    1.7  2  CbiA             CobQ/CobB/MinD/ParA nucleotide binding domai
      0.021   13.8   0.0      0.056   12.4   0.0    1.7  1  AAA_6            Hydrolytic ATP binding site of dynein motor 
      0.025   13.9   0.0      0.053   12.9   0.0    1.5  1  ATPase           KaiC
       0.03   13.9   0.0      0.053   13.1   0.0    1.3  1  AAA_25           AAA domain
      0.039   13.9   0.3       0.15   12.0   0.0    2.1  2  Rad17            Rad17 P-loop domain
      0.045   13.5   0.0      0.093   12.4   0.0    1.6  1  AAA_24           AAA domain
      0.048   13.9   0.0       0.12   12.6   0.0    1.7  1  AAA_22           AAA domain
      0.072   13.0   0.1       0.16   11.9   0.1    1.6  1  AAA_31           AAA domain
        0.1   13.1   0.1       0.51   10.8   0.1    2.2  1  ABC_tran         ABC transporter
        0.1   12.4   0.0        0.2   11.4   0.0    1.5  1  AAA_11           AAA domain
       0.11   12.3   0.0       0.61    9.8   0.0    2.2  2  Viral_helicase1  Viral (Superfamily 1) RNA helicase
       0.11   11.7   0.0       0.23   10.7   0.0    1.5  1  Zeta_toxin       Zeta toxin
       0.12   12.7   0.0        0.3   11.4   0.0    1.6  1  AAA_19           AAA domain
       0.65   10.5   3.9       0.19   12.2   0.7    1.8  2  AAA_23           AAA domain


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.9   0.0   5.7e-21   4.6e-18       2     131 ..     308     444 ..     307     445 .. 0.91

  Alignments for each domain:
  == domain 1  score: 65.9 bits;  conditional E-value: 5.7e-21
                 EEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH................TTCCCHHHHH CS
         AAA   2 llyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksr................sgseseeeer 84 
                 llyG pG+GKT++++++a  l+++++ + + + +      +  +++ lf+++  +   sil++++id++++++                ++  ++++++
  EFC36714.1 308 LLYGEPGCGKTTTISSIAACLNMNICVFTLDSQT------NDTSLNSLFSTVPPN---SILVFEDIDSIFPKEedekksdsatdevshgRSVVKTNTKS 397
                 9************************999999999......889******998554...7***************9999999999997766667888899 PP

                 HHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHHHS.TTSSEEEETT CS
         AAA  85 vvnqLlteldgvkkkeskvivigatnrpdkldpallr.gRfdrkieie 131
                 + +++l+ ldg +++es  iv ++tn  +kl+pal+r gR+drki+++
  EFC36714.1 398 TFSTILNCLDGISSQES-RIVFMTTNFKEKLPPALIRnGRIDRKIYLG 444
                 9999999*****99766.999************************987 PP

>> BCS1_N  BCS1 N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.2   5.7e-08   4.7e-05      17     131 ..      49     170 ..      32     178 .. 0.69
   2 !    7.1   0.0     0.006       4.9     139     187 .]     227     272 ..     221     272 .. 0.91

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 5.7e-08
      BCS1_N  17 slirrrflvsveissdDeaydwvlaWlsaqpasrrs.relsvetrtksrssdssaee.dededeeedg.....kkkkplrylPavgtthlfrykgrlla 108
                 +l+ r+++ ++  s++   y w+  W s++p +++   +++   +t++ + ++++e+ +ed+ ++  +      ++ +++++P++g  h++  +   l 
  EFC36714.1  49 NLLFRWMFYQLNLSDTCIEYAWFSLWFSHHPYTKNGsTHVKPFQKTTKLRVNRTNEPkEEDSIAT--SnisemISNLKVNFVPSYG-IHILYRNSEPLI 144
                 5577899999999999999***********98888755555555555554444444322222222..1345576678*********.7***99999*99 PP

      BCS1_N 109 vtRereekssdsetga...peetltl 131
                 v+ + ++++++++ ++    +e++++
  EFC36714.1 145 VSISINTNQNNNAYNTeekTREDIVI 170
                 99888776666555543334555655 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.006
      BCS1_N 139 eilkeLleearelalkkqegktviyraaagsggeWrrvasRpkRplstV 187
                 ++++eLl ++   +   ++ kt+iy++     ++W   + ++kR   tV
  EFC36714.1 227 SVFRELLCDCFYVHTLMTREKTTIYTPY---FSQWVLASFKEKRAQHTV 272
                 689***********************55...89***9999****98887 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   1.2e-06     0.001       3      41 ..     308     346 ..     306     364 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 1.2e-06
                 EEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHH CS
       AAA_5   3 lLvGppGtgKselaerlaaalnreveyvqltrdtteedl 41 
                 lL G+pG+gK++ + ++aa ln ++ +  l ++t+ + l
  EFC36714.1 308 LLYGEPGCGKTTTISSIAACLNMNICVFTLDSQTNDTSL 346
                 9*******************************9998877 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   3.7e-06     0.003      25     135 ..     305     414 ..     295     425 .. 0.50

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 3.7e-06
      AAA_16  25 elvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawrekleeala...avpelagaeasrll 120
                 +  ll+Ge+G+GK++ + +++  l+ + + +++ + + +  ++++  l ++   +++l  ++ ++     e++ +k ++a+     ++++     ++ +
  EFC36714.1 305 RGYLLYGEPGCGKTTTISSIAACLNMN-ICVFTLDSQTN--DTSLNSLFSTVPPNSILVFEDIDSIF-PKEEDEKKSDSATDevsHGRSVVKTNTKSTF 399
                 789******************666555.33333333333..23333333333333444443333222.2222222222222211123333333336666 PP

      AAA_16 121 ellkrllallsrder 135
                  ++ ++l+ +s++e+
  EFC36714.1 400 STILNCLDGISSQES 414
                 666666644444444 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.2   2.3e-05     0.018       2      64 ..     308     370 ..     307     423 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.3e-05
  RNA_helicase   2 wlyGpsgeGKStlakeLakallkklklkkkdsvysrnpeddfwdgYtgqevvvidDfgqvkde 64 
                   +lyG++g+GK+t++ ++a+ l  ++   + ds    ++ ++ ++    + ++v++D+ ++  +
    EFC36714.1 308 LLYGEPGCGKTTTISSIAACLNMNICVFTLDSQTNDTSLNSLFSTVPPNSILVFEDIDSIFPK 370
                   69*****************99999977777777677788888888888888888887766433 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   9.6e-06    0.0078      37      98 ..     308     369 ..     296     378 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 9.6e-06
      RuvB_N  37 llyGpPGlGkttlakiiakelgvklkitsgPvlekagdlaalltnleekdvlfideihrlsr 98 
                 llyG PG Gktt  + ia+ l++++ + +     + + l +l++++ ++ +l  ++i  + +
  EFC36714.1 308 LLYGEPGCGKTTTISSIAACLNMNICVFTLDSQTNDTSLNSLFSTVPPNSILVFEDIDSIFP 369
                 9**************************99999999*****************9999987755 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   3.1e-05     0.025      23     121 ..     307     417 ..     303     423 .. 0.79
   2 ?   -2.5   0.2       4.8   3.9e+03      61     109 ..     451     505 ..     436     515 .. 0.44

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 3.1e-05
    ATPase_2  23 yfiYGpegsGKtaLlkeiienledkdkyviyyialreesiskldefie................eeeekkklekalgiavpkaeleeilkeksklvfka 105
                 y++YG  g+GKt+ +  i+  l+      ++  + ++ ++s  + f                   +ee++k ++ + ++v   +   ++k+++k  f+ 
  EFC36714.1 307 YLLYGEPGCGKTTTISSIAACLNM--NICVFTLDSQTNDTSLNSLFSTvppnsilvfedidsifPKEEDEKKSDSATDEVSHGRS--VVKTNTKSTFST 401
                 899***************999943..579*********99999999669999999999999998444444445666566655443..677888888888 PP

    ATPase_2 106 ielllekikkkgkkii 121
                 i + l+ i+ +  +i+
  EFC36714.1 402 ILNCLDGISSQESRIV 417
                 8888888888888776 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 4.8
    ATPase_2  61 siskldefieeeeekkklekal....giavpkaeleeilk..eksklvfkaiell 109
                 + + +++f  ee++k+k++++        ++ a+l+ ++   e+   + k+ +++
  EFC36714.1 451 FYKMTQNFYPEEYVKEKVDEMWenmkEYSFGMANLQGFFLrnETLDAAVKSSKNF 505
                 3333444444555555555555333322222233322222334444444444444 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   4.3e-05     0.035      30      80 ..     301     348 ..     292     353 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 4.3e-05
       AAA_7  30 lknkkpvllvGptGtGKtviikdllkkldkekylsltinfsaqtsanqlqd 80 
                 +  ++  ll+G+ G+GKt++i+++   l+   +++ ++++ +qt+ ++l +
  EFC36714.1 301 IPYRRGYLLYGEPGCGKTTTISSIAACLN---MNICVFTLDSQTNDTSLNS 348
                 5667889******************9999...8888888999988777765 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       5.1   4.2e+03      57      97 ..     114     165 ..      89     181 .. 0.68
   2 ?   13.6   0.0   6.3e-05     0.052       9      55 ..     314     394 ..     308     495 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 5.1
                 HCCCHHHHHHCHCHHHH.............EEEEEEEEESS...-TTCHHHH CS
                 xxxxxxxxxxxxxxxxx...........xxxxxxxxxxxxxxxxxxxxxxxx RF
        CbiA  57 krllellealgkkkall...........lkiagvvlnrvdgeneetllkeal 97 
                 + ++e++++l+ ++ +             +i+++ +n  +++n+++ +++  
  EFC36714.1 114 SNISEMISNLKVNFVPSygihilyrnsePLIVSISINTNQNNNAYNTEEKTR 165
                 5667777777777666666666666666666666666666666666665555 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 6.3e-05
                 TSSHHHHHHHHHHHHHHTT--EEEEEEEESSCCCCH..HTTEB-HHHH...................................C CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxx...................................x RF
        CbiA   9 GvGKTtlaanLaralarrglrVllvDaDpqannlai..leglendiep...................................d 55 
                 G GKTt+  ++a++l+    ++ ++ +D q+n +++  l+ +++                                       +
  EFC36714.1 314 GCGKTTTISSIAACLNM---NICVFTLDSQTNDTSLnsLFSTVPPNSIlvfedidsifpkeedekksdsatdevshgrsvvktN 394
                 99**************9...9999999999999996553333333322455555555555555555555555555555555550 PP

>> AAA_6  Hydrolytic ATP binding site of dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   6.9e-05     0.056      34      79 ..     306     351 ..     299     367 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.9e-05
       AAA_6  34 ggapaGpagtGKtEtvkdLakalakqvvvfncsdqldykslgkifk 79 
                 g  ++G  g GKt t+ ++a +l + ++vf  + q + +sl+ +f+
  EFC36714.1 306 GYLLYGEPGCGKTTTISSIAACLNMNICVFTLDSQTNDTSLNSLFS 351
                 56678999**********************************9998 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   6.6e-05     0.053      14      35 ..     299     320 ..     277     326 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 6.6e-05
      ATPase  14 gGipegrvvlitGepGtGKtif 35 
                 +Gip +r +l++GepG+GKt+ 
  EFC36714.1 299 RGIPYRRGYLLYGEPGCGKTTT 320
                 8*******************85 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   6.5e-05     0.053      19      57 ..     290     328 ..     279     332 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 6.5e-05
      AAA_25  19 ppprrwlvkgllpagelallaGapgtGKttlaldlalav 57 
                 +++++w+ ++ +p     ll+G pg+GKtt  +++a+++
  EFC36714.1 290 LKSKQWYKDRGIPYRRGYLLYGEPGCGKTTTISSIAACL 328
                 556677777777888889******************985 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.3       6.8   5.5e+03     164     185 ..     139     159 ..     134     160 .. 0.75
   2 ?   12.0   0.0   0.00018      0.15      27      72 ..     288     331 ..     278     350 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 6.8
       Rad17 164 ealplilviteieslegdnnqr 185
                 ++ pli+ i+ i++ +++n ++
  EFC36714.1 139 NSEPLIVSIS-INTNQNNNAYN 159
                 4448999999.99999998875 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 0.00018
       Rad17  27 kieevkewlkadvLesrkkriLLisGPsGCgkstvvkvLskelgik 72 
                 k  + k+w k   ++ r  r  L+ G +GCgk+t++  ++  l ++
  EFC36714.1 288 KFLKSKQWYKDRGIPYR--RGYLLYGEPGCGKTTTISSIAACLNMN 331
                 55556777777777777..678899***********9998776554 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   0.00011     0.093       5      23 ..     307     329 ..     304     380 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00011
      AAA_24   5 iliyGpsgiGKTtlakel....g 23 
                 +l+yG++g GKTt+++++     
  EFC36714.1 307 YLLYGEPGCGKTTTISSIaaclN 329
                 689************99854444 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   0.00015      0.12       8      42 ..     307     332 ..     302     357 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00015
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaeeerpev 42 
                  +++Ge+G+GKTt++  ++  l         +  +
  EFC36714.1 307 YLLYGEPGCGKTTTISSIAACL---------NMNI 332
                 689***********99888776.........4444 PP

>> AAA_31  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   0.00019      0.16      12      50 ..     314     349 ..     311     427 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00019
      AAA_31  12 GvGKTTtsvnlaaalaklgkkvLlvDlDpQanattglgi 50 
                 G GKTTt   +aa+l   ++ + +  lD+Q+n t+  ++
  EFC36714.1 314 GCGKTTTISSIAACL---NMNICVFTLDSQTNDTSLNSL 349
                 99**********998...5679999********995544 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   0.00063      0.51      14      37 ..     307     330 ..     300     487 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00063
                 EEEEESTTSSHHHHHHHHTTSS-- CS
                 xxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkp 37 
                 + + Ge G+GK+t ++ +a  l+ 
  EFC36714.1 307 YLLYGEPGCGKTTTISSIAACLNM 330
                 6799*************9987765 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00025       0.2      20      43 ..     307     339 ..     284     407 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00025
      AAA_11  20 tliqGPPGtgKTktivellsqll.........s 43 
                  l+ G PG+gKT+ti ++ + l+         s
  EFC36714.1 307 YLLYGEPGCGKTTTISSIAACLNmnicvftldS 339
                 5899**************999974444443331 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       1.9   1.5e+03      47      71 ..     252     277 ..     229     279 .. 0.62
   2 ?    9.8   0.0   0.00075      0.61       5      34 ..     311     334 ..     308     362 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.9
  Viral_helicase1  47 vrtvdsflmalvks.tkgkililDEy 71 
                      + ++ ++  a  k+    +++ilDE 
       EFC36714.1 252 TPYFSQWVLASFKEkRAQHTVILDEG 277
                      34444444444444445689****96 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00075
  Viral_helicase1   5 GvpGcGKStlirkllrtsliltvnrptael 34 
                      G pGcGK+t i +++         ++++++
       EFC36714.1 311 GEPGCGKTTTISSIAAC------LNMNICV 334
                      77*********999855......3333333 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00029      0.23      18      52 ..     306     338 ..     287     341 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00029
  Zeta_toxin  18 lillgGqpGAGKselaellkdelerqgnvvrldpD 52 
                  +ll G pG+GK+++++ +++ l  + n+ ++  D
  EFC36714.1 306 GYLLYGEPGCGKTTTISSIAACL--NMNICVFTLD 338
                 58999**************9999..6776666665 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00037       0.3      13      35 ..     307     329 ..     303     336 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00037
      AAA_19  13 llvtaGpGtGKTrvlkhivallv 35 
                  l+ + pG+GKT+++  i a+l+
  EFC36714.1 307 YLLYGEPGCGKTTTISSIAACLN 329
                 6899*************999876 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       7.8   6.3e+03      73      73 ..     130     130 ..      82     170 .. 0.44
   2 ?   12.2   0.7   0.00023      0.19      23     122 ..     308     400 ..     305     515 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 7.8
      AAA_23  73 a 73 
                 +
  EFC36714.1 130 S 130
                 1 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00023
      AAA_23  23 lItGpNGaGKTTildAiklaLygetprlsrksgrgfeksdveiese.gkvkayveltfenkdgrytrsiererelskkkgkttkkaklelleideleqf 120
                 l++G+ G+GKTT +  i  +L      +  + +  + ++d +++s   +v++   l fe++d +   + ++e e++++++       ++ ++++++  +
  EFC36714.1 308 LLYGEPGCGKTTTISSIAACLNMNI--CVFTLD--SQTNDTSLNSLfSTVPPNSILVFEDIDSI---FPKEEDEKKSDSATDEVSHGRSVVKTNTK-ST 398
                 89*******************7633..333223..33333333333224444445557777774...45555555555444444444444444333.33 PP

      AAA_23 121 is 122
                 +s
  EFC36714.1 399 FS 400
                 33 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (518 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       930  (0.0518713); expected 358.6 (0.02)
Passed bias filter:                      555  (0.0309554); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              22  [number of targets reported over threshold]
# CPU time: 0.54u 0.23s 00:00:00.77 Elapsed: 00:00:00.41
# Mc/sec: 3830.13
//
Query:       EFC36715.1  [L=115]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (115 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1018  (0.0567795); expected 358.6 (0.02)
Passed bias filter:                      628  (0.0350271); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.27s 00:00:00.71 Elapsed: 00:00:00.42
# Mc/sec: 816.97
//
Query:       EFC36716.1  [L=218]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       445  (0.0248201); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1276.83
//
Query:       EFC36717.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-55  188.2   8.2    1.7e-55  187.9   8.2    1.0  1  ATP-synt_D  ATP synthase subunit D
  ------ inclusion threshold ------
      0.066   13.4   1.9         14    5.9   0.5    3.0  2  MatP_C      MatP C-terminal ribbon-helix-helix domain
       0.09   12.7   1.4       0.21   11.5   0.1    2.1  2  DUF1054     Protein of unknown function (DUF1054)


Domain annotation for each model (and alignments):
>> ATP-synt_D  ATP synthase subunit D
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  187.9   8.2   2.8e-59   1.7e-55       2     195 ..      18     217 ..      17     218 .. 0.94

  Alignments for each domain:
  == domain 1  score: 187.9 bits;  conditional E-value: 2.8e-59
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSTST.TSTSHHHHHHHSSS.SS-..TSS-SEEEEEEBTTSEEEEE. CS
  ATP-synt_D   2 LirlkkrlklaqrghslLkkKrdaLilefreilkelkelreeleeelkeayfslaea.faaggeediesavlesvklakvvkvelktenvaGVkvpvf. 98 
                 L+ +++rl+ a+rg+s+L kK+daL+ +f +i++e+ke +e +   ++++ fsl+ea ++ag   d++ av esvk a+ ++v++++env GVk+ vf 
  EFC36717.1  18 LQLMENRLNSAKRGQSMLSKKSDALRNKFYSIVNEIKEEKEGMTSLFRKSFFSLTEArYSAG---DLSFAVTESVKSAA-IRVTSHMENVSGVKFAVFt 112
                 899******************************************************99999...9**********999.******************6 PP

                 ..EE-...........S.SSTSSSSSSSSTCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHHH CS
  ATP-synt_D  99 ..eleee.........ksdstelygllrtgaqldeavealrellellvelasletslelLdeeikktnrRvNaLekvvIPrleetikyIkseLdEqere 186
                   +   +         + ++t+l  l+r+g+++++++ +++e+l+++++la+l+ts+++Ld++ik tnrRvNaLek++ P++ +ti+yI++eL+  e+e
  EFC36717.1 113 qvD---NqedklqmkkSPSRTQLSFLSRGGEEIQNCKLTFSETLHKMIRLANLQTSFISLDQAIKSTNRRVNALEKIIQPKISNTISYINEELEQTEKE 208
                 551...34556666676778899999************************************************************************* PP

                 HHHHHHHHH CS
  ATP-synt_D 187 effrlkkvk 195
                 +++rlkk++
  EFC36717.1 209 DIYRLKKIR 217
                 *******98 PP

>> MatP_C  MatP C-terminal ribbon-helix-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0    0.0029        17      22      40 ..     143     161 ..     132     175 .. 0.83
   2 ?    5.9   0.5    0.0024        14      25      46 ..     188     209 ..     169     222 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0029
      MatP_C  22 qrrgsTLSetivqLieeae 40 
                 q+ ++T Set++++i  a+
  EFC36717.1 143 QNCKLTFSETLHKMIRLAN 161
                 78899*********97655 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0024
      MatP_C  25 gsTLSetivqLieeaerkekye 46 
                 +  +S+ti+++ ee e++ek +
  EFC36717.1 188 QPKISNTISYINEELEQTEKED 209
                 5568*************99854 PP

>> DUF1054  Protein of unknown function (DUF1054)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.13   7.8e+02     123     144 ..      42      63 ..      14     131 .. 0.56
   2 ?   11.5   0.1   3.6e-05      0.21      12      49 ..     174     211 ..     166     218 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.13
                 S-TT-EEES-TTS---EEGGG- CS
     DUF1054 123 lpkdfvvskdhtkkeakslsel 144
                 l ++f+   ++ k+e++ +++l
  EFC36717.1  42 LRNKFYSIVNEIKEEKEGMTSL 63 
                 4444444444444444433333 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 3.6e-05
                 -SHHHHHHHHTTTHHHHHHHHHHHHHHHHHHHHSS--E CS
     DUF1054  12 egLeeRmeaireeirPkleelgeelapelsaetgeely 49 
                 +  ++R++a+++ i+Pk+++  +++++el+++ +e++y
  EFC36717.1 174 KSTNRRVNALEKIIQPKISNTISYINEELEQTEKEDIY 211
                 66689**************************9999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1482  (0.0826594); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1518.32
//
Query:       EFC36718.1  [L=726]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.3e-13   48.7   0.1    2.9e-12   46.8   0.1    2.0  2  BTB             BTB/POZ domain
  ------ inclusion threshold ------
      0.033   14.8   0.0      0.077   13.6   0.0    1.6  1  Fapy_DNA_glyco  Formamidopyrimidine-DNA glycosylase N-termina


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.8   0.1   3.2e-16   2.9e-12       7     110 ..     546     661 ..     542     662 .. 0.84
   2 ?   -2.7   0.0      0.77   6.9e+03       9      34 ..     672     694 ..     665     694 .. 0.77

  Alignments for each domain:
  == domain 1  score: 46.8 bits;  conditional E-value: 3.2e-16
                 HTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCE............EEEETTSGH..HHHHHHHHHHHHSEEEC-CGGGHHHHHHHH CS
         BTB   7 sgelcDvtlvvgdgkefkahkavLaarSpyFkalftskeieessvs............eielddvep..eafealLefiYtgeleitseenleelLaaa 91 
                 +++  D+tlv+  g+++ ahk vLa+ Sp++++++ ++++ +s+v+            ei+ +d e   e fe l++f+Yt+ ++ +  e++  l ++a
  EFC36718.1 546 RQDTHDITLVAY-GRKIGAHKTVLASTSPILEVMLDEEGSFKSEVTenqelvlggedlEIPEKDREKkgELFELLVKFCYTSSVDCS-PEDAFLLYEMA 642
                 56789*******.9************************555555555566778999777776666653369***************6.*********** PP

                 HHHT-HHHHHHHHHHHHHH CS
         BTB  92 dllqiprlkkaceeflkqs 110
                 d +qi +lk+ + ++++ +
  EFC36718.1 643 DQYQITDLKTSLADKIIAQ 661
                 **********999888765 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.77
                 TTS-EEEEETTTEEEEE-HHHHHHH- CS
         BTB   9 elcDvtlvvgdgkefkahkavLaarS 34 
                 +++D+ +++ + k  + h+ +L  +S
  EFC36718.1 672 KWSDIFVQISN-K--HLHRGILNFAS 694
                 67999999995.5..88999987765 PP

>> Fapy_DNA_glyco  Formamidopyrimidine-DNA glycosylase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   8.6e-06     0.077      44      82 ..      94     133 ..      64     172 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 8.6e-06
                     T-.SEEEEEEEEETTEEEEEE..EEEEEEE-TTTEEE.SS CS
  Fapy_DNA_glyco  44 alkgrkiasvgrrGKyllleldggevlvvhlgmtGrl.li 82 
                      ++g   ++v+r GK++l+  d+++  v+hl m+ ++  i
      EFC36718.1  94 PVRGLHCTKVDRDGKVILISSDRKSLQVFHLEMKSKIaDI 133
                     5789999**************9999999******998444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (726 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       505  (0.0281667); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.25s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 5046.99
//
Query:       EFC36719.1  [L=2028]
Description: basal body protein NBP-2 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-49  168.5   0.0    2.9e-49  167.8   0.0    1.3  1  Pkinase         Protein kinase domain
    2.5e-30  104.5 146.3    6.3e-05   23.3   9.8    9.5  9  EGF_2           EGF-like domain
    1.1e-29  103.5   0.0    1.9e-29  102.8   0.0    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    0.00011   21.1   0.0    0.00025   20.0   0.0    1.5  1  Pkinase_fungal  Fungal protein kinase
     0.0023   17.8   0.9     0.0023   17.8   0.9    2.1  2  TMEM154         TMEM154 protein family
  ------ inclusion threshold ------
      0.014   14.9   5.3      0.042   13.4   0.7    2.9  2  Stevor          Subtelomeric Variable Open Reading frame
      0.015   15.6 103.7       0.13   12.6   2.3    9.7  9  EGF             EGF-like domain
      0.029   14.6   0.4      0.074   13.3   0.4    1.6  1  Chordopox_A13L  Chordopoxvirus A13L protein
       0.22   11.3   1.6        0.8    9.5   1.6    2.0  1  RIFIN           Rifin
        0.6   10.0  10.6      0.055   13.3   3.4    3.0  2  ODV-E18         Occlusion-derived virus envelope protein ODV-


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  167.8   0.0   1.6e-52   2.9e-49       1     264 []    1744    2003 ..    1744    2003 .. 0.88

  Alignments for each domain:
  == domain 1  score: 167.8 bits;  conditional E-value: 1.6e-52
                  EEEEEEEEEESSEEEEEEEET.TTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEE.EEEE--TTEBHHHHHHHHSS- CS
     Pkinase    1 yekleklGeGsfGkVykavek.etgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely.lvleyveggeladllerkgsl 95  
                  y ++ k+G+G+fG+V+k+v++ + gk  A+K+i+ ++  + +  ++l+E ++l +++hp+i+++ e++ +kd+++ + ++++e g+l++l      +
  EFC36719.1 1744 YADMVKIGQGAFGSVFKGVDTkQAGKLKAIKVIRFNSVGELN--NMLKEGTMLMNIDHPHILKVNEFIIDKDNILcIDTDFCEDGDLTKLTLSAEPI 1838
                  56788**************85156788899999999999876..5*************************999875889************9999** PP

                  -HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHH CS
     Pkinase   96 seeeakkiakqilegleylH.skgiiHrDlKpeNiLidekge....lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvil 187 
                  +e  +k++++q++++l+++H + +iiHrD+Kp+Ni+++e  +      ++DFGlak+ +++s ++s+ gt+ Y++PE+  + +y  ++D WslGv+ 
  EFC36719.1 1839 PEPIIKQVIYQMCSALAFIHnKLKIIHRDVKPHNIFLKELTDfsvqTVLADFGLAKQDQNNS-MNSYAGTPLYMSPELALGGKYNYNTDTWSLGVVA 1934
                  ********************6678**************7444566689*********99988.********************************** PP

                  HHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase  188 yelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264 
                  y+l+t+    + ++   +          + ++ +  + kl+e  + se +k+++ ++l+kd  +R+  +el++ p++
  EFC36719.1 1935 YQLMTKDITTALSHLCLTGD--------SEDTKKRIRAKLDETGQYSEALKEIVISMLEKDAASRPFPQELVDRPFF 2003
                  ******99988333322222........223334556789999999*****************************98 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   9.2   1.3e-06    0.0023       5      32 .]     345     372 ..     337     372 .. 0.89
   2 !   19.2   5.8   6.7e-07    0.0012       5      32 .]     386     412 ..     382     412 .. 0.89
   3 !   10.5  10.1   0.00035      0.63       5      32 .]     425     452 ..     417     452 .. 0.77
   4 !   23.3   9.8   3.5e-08   6.3e-05       5      32 .]     465     491 ..     461     491 .. 0.86
   5 !   20.7   8.3   2.3e-07    0.0004       4      32 .]     503     530 ..     499     530 .. 0.88
   6 !   14.8   8.2   1.6e-05     0.028       5      32 .]     544     570 ..     539     570 .. 0.88
   7 !   18.3   8.9   1.3e-06    0.0023       5      32 .]     583     609 ..     580     609 .. 0.90
   8 !   20.4  11.2   2.7e-07   0.00049       6      32 .]     623     648 ..     619     648 .. 0.90
   9 !    9.9  10.9   0.00054      0.97       5      32 .]     661     687 ..     657     687 .. 0.90

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 1.3e-06
       EGF_2   5 deiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C++ +GtC+++   C+C++gy+G +C
  EFC36719.1 345 QSVCSNsNGTCIAPD-TCSCKAGYTGSKC 372
                 789*********999.9************ PP

  == domain 2  score: 19.2 bits;  conditional E-value: 6.7e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+g+G+Cv++   C+C+++y+G  C
  EFC36719.1 386 ANACSGRGSCVAKD-TCVCQPNYSGLAC 412
                 689********999.9*********999 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.00035
       EGF_2   5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                  + C+ +G+C +  + C C ++ y+G +C
  EFC36719.1 425 ANVCSRRGSCTA-YNTCTCsQNYYYGTDC 452
                 789*******84.559***666666**** PP

  == domain 4  score: 23.3 bits;  conditional E-value: 3.5e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG C +  +qC+C+s+++G +C
  EFC36719.1 465 SSVCSGHGNCLD-YNQCSCSSKWYGSYC 491
                 689*******64.55************* PP

  == domain 5  score: 20.7 bits;  conditional E-value: 2.3e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C+g GtC+ ++ +C C++gy G +C
  EFC36719.1 503 SSNVCSGAGTCNLPN-NCTCNAGYNGTNC 530
                 3799********666.8************ PP

  == domain 6  score: 14.8 bits;  conditional E-value: 1.6e-05
       EGF_2   5 deiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                 +++C+ +GtC   + G C+C + y+Gk C
  EFC36719.1 544 QSACQHNGTCS--GpGACSCLPTYYGKIC 570
                 789********..667***********88 PP

  == domain 7  score: 18.3 bits;  conditional E-value: 1.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hGtC  ++  C+C+++y+G++C
  EFC36719.1 583 SSVCSSHGTCTMLN-TCECSQNYYGNNC 609
                 678*******9888.9************ PP

  == domain 8  score: 20.4 bits;  conditional E-value: 2.7e-07
       EGF_2   6 eiCgghGtCvnqcGq.CdCdsgyqGktC 32 
                 + C+ +G+C+  +G+ C+C++gy+G++C
  EFC36719.1 623 SVCSARGKCI--GGNnCKCNNGYTGANC 648
                 57********..9855************ PP

  == domain 9  score: 9.9 bits;  conditional E-value: 0.00054
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G+C ++   C+C +gy G++C
  EFC36719.1 661 SNVCSSRGSCGAPD-SCQCTNGYRGPNC 687
                 689*******9899.7************ PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  102.8   0.0     1e-32   1.9e-29       6     256 ..    1749    1998 ..    1746    2000 .. 0.81

  Alignments for each domain:
  == domain 1  score: 102.8 bits;  conditional E-value: 1e-32
                   EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSS.EEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr    6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeep.llivteyvkgGdLlkfLrkkekekl 100 
                   k+G+GafG+V++g  +   +++    a+K+++ ++  e  +++l+e +++++++hp+i+k+  +++++++ l+i t++++ GdL k   +   e++
   EFC36719.1 1749 KIGQGAFGSVFKGVDT---KQAGKLKAIKVIRFNSVGE-LNNMLKEGTMLMNIDHPHILKVNEFIIDKDNiLCIDTDFCEDGDLTKLTLSA--EPI 1838
                   79***********998...56666679****7766665.9**************************666637888*********9866654..9** PP

                   BHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHH CS
  Pkinase_Tyr  101 tlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsf 191 
                       + ++++q++++++++++k k++Hrd+   N++l+e    + +  ++DfGLa++    ++ ++ ++      +m+pE    +k++ ++D Ws 
   EFC36719.1 1839 PEPIIKQVIYQMCSALAFIHNKlKIIHRDVKPHNIFLKEltdfSVQTVLADFGLAKQD---QN-NSMNSYAGTPLYMSPELALGGKYNYNTDTWSL 1930
                   *******************98857**************98877667789******987...33.334444455569******************** PP

                   HHHHHHHHTTSSGT.TTTSHHHHHHHHHHT..TEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr  192 GvllwEiftlgesp.ypglkneevleklke..gkrlekpekcpeelyelmkkcweedpeeRptfselv 256 
                   Gv+ + ++t+  ++ +++l  +   e  k+  + +l++  + +e+l+e++ + +e+d+++Rp  +elv
   EFC36719.1 1931 GVVAYQLMTKDITTaLSHLCLTGDSEDTKKriRAKLDETGQYSEALKEIVISMLEKDAASRPFPQELV 1998
                   ********9644332344333333333333003457778889999****************9888776 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.0   1.4e-07   0.00025     317     396 ..    1852    1926 ..    1843    1935 .. 0.83

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1.4e-07
  Pkinase_fungal  317 kghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhD 396 
                       ++   ++k +i+HrD+  +Ni + +  ++ + + +L+D+ lak+ +++s++s      GT+ +m+ e+  g++ +y  D
      EFC36719.1 1852 SALAFIHNKLKIIHRDVKPHNIFLKEL-TDFSVQTVLADFGLAKQDQNNSMNS----YAGTPLYMSPELALGGKYNYNTD 1926
                      5666778999***************66.5569999**********99765555....68*******99999888877766 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.4       3.8   6.7e+03      17      36 ..    1463    1482 ..    1452    1498 .. 0.58
   2 !   17.8   0.9   1.3e-06    0.0023      45     107 ..    1649    1710 ..    1612    1725 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.8
     TMEM154   17 leeesadatsaasteseslk 36  
                  +++++  +t+++st+ +s  
  EFC36719.1 1463 ITDVTNSTTTTTSTIVDSSG 1482
                  44455555555555444433 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 1.3e-06
     TMEM154   45 ssaelsnesdqlelvlmiiiPlvllillllvvi.iliqkkkrkrsKddekseaesdeldsenvk 107 
                  +   ++n+   +  vl  ++Pl+l++++++vv+ i+i  +krk+s d   s++++ el + nv 
  EFC36719.1 1649 KTVTTDNTGVVVGAVLGTLLPLILIAVIVVVVViIVIILYKRKKSLDS--SQVQNVELVNKNVS 1710
                  344556666666779999******999887665055556666666655..89988888887775 PP

>> Stevor  Subtelomeric Variable Open Reading frame
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.3     0.059   1.1e+02     153     240 ..       6      92 ..       2      94 .. 0.60
   2 ?   13.4   0.7   2.3e-05     0.042     198     262 ..    1631    1692 ..    1589    1697 .. 0.64

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.059
      Stevor 153 icvcsvgsvlltliglaaakaaavaakvalsaealkklasslsilnlfsesslesalkaavsaaaasdlagtaasaassafepygiaa 240
                 i+ c + ++l  +i     ++aav++ v ++  +l +    +  +++ +++++   + a+  +  ++ ++gt +++  sa++pygia+
  EFC36719.1   6 IIGCFLFTLLFIMIFGSWVSNAAVSIDVNYNIYQLVASFYNIRSMDFDKQNNILYIVGANNKVVKYTAASGT-TEYDASAYTPYGIAV 92 
                 555666666555555555566667774444444444445555666666677777655555555555555554.6788899******96 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 2.3e-05
      Stevor  198 nlfsesslesalk.aavsaaaasdlagtaasaassafepygiaalvllilavvliiLYiwlyrRRK 262 
                  +l s   +++ +  ++ s ++++d +g++++a+ +++ p  + a++++++++++ii    ly+R+K
  EFC36719.1 1631 HLTSFGVVSAIIPpTSQSKTVTTDNTGVVVGAVLGTLLPLILIAVIVVVVVIIVII----LYKRKK 1692
                  33333444444446778888889999999999999999986666655555555555....556655 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   2.9   0.00016      0.29       8      31 ..     351     370 ..     347     371 .. 0.91
   2 ?   12.6   2.3   7.1e-05      0.13       5      30 ..     387     409 ..     383     410 .. 0.88
   3 ?    0.7   3.4      0.37   6.7e+02       5      28 ..     426     446 ..     422     450 .. 0.83
   4 ?    2.4   2.2      0.11     2e+02       6      31 ..     468     489 ..     461     490 .. 0.84
   5 ?    3.1   8.0     0.069   1.2e+02       3      31 ..     504     528 ..     502     529 .. 0.79
   6 ?    4.8   7.0     0.019        35       6      31 ..     547     568 ..     541     568 .. 0.80
   7 ?   10.2   3.3   0.00042      0.75       6      32 .]     586     608 ..     579     608 .. 0.88
   8 ?    7.3   6.6    0.0032       5.7       5      32 .]     622     647 ..     619     647 .. 0.86
   9 ?   11.6   5.3   0.00015      0.27       3      32 .]     661     686 ..     658     686 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00016
                 TT-EEEEETTTEEEEEECTTEEST CS
         EGF   8 ngGtCvdtgrggytCiCpeGytGk 31 
                  +GtC+ +     tC C+ GytG+
  EFC36719.1 351 SNGTCIAPD----TCSCKAGYTGS 370
                 699******....**********7 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 7.1e-05
                 T.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytG 30 
                 + Cs++G Cv       tC C++ y+G
  EFC36719.1 387 NaCSGRGSCVAKD----TCVCQPNYSG 409
                 35***********....*********9 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.37
                 T.STTT-EEEEETTTEEEEEECTTE CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGy 28 
                 + Cs +G C  +     tC+C++ y
  EFC36719.1 426 NvCSRRGSCTAYN----TCTCSQNY 446
                 449******9999....*****996 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.11
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C+d+     +C C++ + G+
  EFC36719.1 468 CSGHGNCLDYN----QCSCSSKWYGS 489
                 **********9....9***9877775 PP

  == domain 5  score: 3.1 bits;  conditional E-value: 0.069
                 STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 +n Cs+ GtC  +     +C+C  Gy G 
  EFC36719.1 504 SNVCSGAGTCNLP----NNCTCNAGYNGT 528
                 466*******444....48*******995 PP

  == domain 6  score: 4.8 bits;  conditional E-value: 0.019
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+++GtC    +g   C C + y Gk
  EFC36719.1 547 CQHNGTC----SGPGACSCLPTYYGK 568
                 *******....68899***9888775 PP

  == domain 7  score: 10.2 bits;  conditional E-value: 0.00042
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs +GtC  +     tC+C++ y G++
  EFC36719.1 586 CSSHGTCTMLN----TCECSQNYYGNN 608
                 *******9999....**********86 PP

  == domain 8  score: 7.3 bits;  conditional E-value: 0.0032
                 T..STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGkr 32 
                 +  Cs +G+C     gg +C+C +GytG++
  EFC36719.1 622 TsvCSARGKC----IGGNNCKCNNGYTGAN 647
                 455*******....6999**********86 PP

  == domain 9  score: 11.6 bits;  conditional E-value: 0.00015
                 STTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGkr 32 
                 +n Cs +G C  +     +C+C++Gy G++
  EFC36719.1 661 SNVCSSRGSCGAPD----SCQCTNGYRGPN 686
                 356*******5555....**********86 PP

>> Chordopox_A13L  Chordopoxvirus A13L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.4   4.1e-05     0.074       5      40 ..    1670    1705 ..    1667    1729 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 4.1e-05
  Chordopox_A13L    5 lllliiCvaivglivYgiYnrkketqttnpstveey 40  
                      l+l+++ v++v++iv  +Y+rkk+    + + ve  
      EFC36719.1 1670 LILIAVIVVVVVIIVIILYKRKKSLDSSQVQNVELV 1705
                      79*********************9888777765544 PP

>> RIFIN  Rifin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   1.6   0.00045       0.8     284     310 ..    1670    1695 ..    1638    1707 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00045
       RIFIN  284 ivaivvIvLimvIIYLiLRYrRKkKmk 310 
                   + i vIv+++vII +iL Y+RKk   
  EFC36719.1 1670 LILIAVIVVVVVIIVIIL-YKRKKSLD 1695
                  577889999999998888.88888654 PP

>> ODV-E18  Occlusion-derived virus envelope protein ODV-E18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.7       1.8   3.2e+03      33      65 ..    1314    1347 ..    1307    1357 .. 0.55
   2 ?   13.3   3.4   3.1e-05     0.055       8      54 ..    1653    1697 ..    1645    1709 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.8
     ODV-E18   33 vlviiillvllvqssstGsdss.ssnannartGf 65  
                  v+ +  ll+l++q  s+ + +s  s a+ + t +
  EFC36719.1 1314 VVTMHSLLLLIIQQNSVSEFASiDSTAKTTLTTL 1347
                  5556667777777776555444144444444444 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 3.1e-05
     ODV-E18    8 ttstdagstrrlarlePsllltilvvlviiillvllvqssstGsdss 54  
                  t +t   +   l  l P +l++++vv+v+ii+++l+ +  s   dss
  EFC36719.1 1653 TDNTGVVVGAVLGTLLPLILIAVIVVVVVIIVIILYKRKKS--LDSS 1697
                  4455566778999*********************9998888..4554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2028 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1327  (0.0740142); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        90  (0.0050198); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.30u 0.32s 00:00:01.62 Elapsed: 00:00:00.51
# Mc/sec: 11957.15
//
Query:       EFC36720.1  [L=661]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-06   28.9   4.0    1.4e-05   25.3   0.2    2.6  2  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.1   0.5     0.003        55      23      81 ..     271     337 ..     267     348 .. 0.88
   2 !   25.3   0.2   7.9e-10   1.4e-05       3     102 ..     539     639 ..     537     647 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.003
                 TCTHHHHHHHHHHHHHTS........SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHC CS
         RGS  23 fseenlsFwlaveefkka........keqeelkkkakeIyneylapsspkelnidkklreelekrle 81 
                 ++e+nl+ + +v++ +++        +++e+++++ ++I n++  + s +  n+++   +e++++ +
  EFC36720.1 271 QQENNLQILSEVKGTQSTfdvnenihTNDESTVTDDEDITNTFTLNTSRSTWNLSDINSKEVQSQAR 337
                 67899999999999999999999999999*********************99*99988888887655 PP

  == domain 2  score: 25.3 bits;  conditional E-value: 7.9e-10
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS...STTTTTTHHHHHHHH CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke...qpsrklfeeaqeevf 98 
                 e++l ++   ++  +F +++++ e +  w ++++++k+  ++ +kk a+ I+++yl  +sp elni++  +++le     e   +  ++lf+ ++++++
  EFC36720.1 539 ERVLMNKRTFNIVLDFGRRSYCVESVLAWRDIQRYQKS--RRHRKKIAQHIISTYLTIGSPFELNISNIEKKRLEYSTIIEeskKLESSLFDSLESHCL 635
                 677888888889999**********************9..8889999*******************998888877654333345788899999999999 PP

                 HHHH CS
         RGS  99 elle 102
                 + + 
  EFC36720.1 636 SDMT 639
                 8885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (661 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1845  (0.102906); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.76u 0.34s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 3792.18
//
Query:       EFC36721.1  [L=883]
Description: hypothetical protein NAEGRDRAFT_82145 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.066   13.7   0.4        1.1    9.7   0.0    3.2  3  SPG48     AP-5 complex subunit, vesicle trafficking
       0.11   13.2   0.2       0.46   11.1   0.2    2.1  1  CPG4      Chondroitin proteoglycan 4


Domain annotation for each model (and alignments):
>> SPG48  AP-5 complex subunit, vesicle trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.63   5.6e+03      20      58 ..     119     158 ..     115     173 .. 0.68
   2 ?   -1.0   0.0      0.26   2.3e+03      40      61 ..     619     640 ..     583     656 .. 0.79
   3 ?    9.7   0.0   0.00012       1.1      80     118 .]     772     810 ..     762     810 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.63
       SPG48  20 dsslvarvlptikrllq.rlasdlskarllLailqFfLnh 58 
                 +++ + + + + kr++q + +++l+     L   q+f+ h
  EFC36721.1 119 EEKALKQFFDCCKRIYQsKQEAELETGVESLENWQYFILH 158
                 5667778888889998855555555555566666666655 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.26
       SPG48  40 sdlskarllLailqFfLnhgea 61 
                 ++l++ + l+  ++Ff+n ge+
  EFC36721.1 619 EKLGYYQFLIEFIEFFINEGEH 640
                 4567778899999999999988 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00012
       SPG48  80 eefadpvlafetvqflrenlekLlkstsllkqyfPnllK 118
                 e   d++++ +++++++ n+++++k  +++ q++P++ K
  EFC36721.1 772 EDALDEAISNAVITLILLNRHQIEKVAEIVMQFMPVIYK 810
                 5567999******************************98 PP

>> CPG4  Chondroitin proteoglycan 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   5.1e-05      0.46       6      71 ..     462     529 ..     459     535 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.1e-05
        CPG4   6 Clkplakalkkllkaknt.verlkklCskleeaseCvakekkCedkklf....ealtsgleyvCidkeeal 71 
                 C ++l k+     ++++  ++++ ++C+ l+ +++C+ ++++   + ++    + + + +e+vC+d ++++
  EFC36721.1 462 CSDDLLKSI---IQSHELvTDDVTDFCEMLQGVAKCFGNDHSIVGESVLesfgSLIYKIFEIVCVDDKKKY 529
                 777777666...445554499****************99887744444411114567889*****998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (883 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.32s 00:00:01.08 Elapsed: 00:00:00.53
# Mc/sec: 5025.84
//
Query:       EFC36722.1  [L=331]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.068   12.9   0.3        1.8    8.3   0.1    2.4  2  Imm53     Immunity protein 53
        3.2    8.3   5.9         30    5.1   2.9    2.6  2  DUF4598   Domain of unknown function (DUF4598)


Domain annotation for each model (and alignments):
>> Imm53  Immunity protein 53
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.1    0.0002       1.8      41      87 ..     161     209 ..     142     212 .. 0.85
   2 ?    2.1   0.0     0.018   1.6e+02      43      82 ..     252     291 ..     238     298 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0002
       Imm53  41 tsleklkieeikverseddWlkvkveea..kfegagdprkLeeileifk 87 
                 ++ e+++i++  +++s d W + k +e+  +fe++ d++++e ile+++
  EFC36722.1 161 KKSEEQSIKKRAKKSSPDLWEHTKFSESapYFEIVTDVKEMELILEVAQ 209
                 4566777788888888889******999889**************9876 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.018
       Imm53  43 leklkieeikverseddWlkvkveeakfegagdprkLeei 82 
                 l+k++i + ++++++  W+++k + ++f  +++  k +++
  EFC36722.1 252 LDKKTIYNGEKSSKSYTWIRLKGTSEYFFLYCQTGKTNAV 291
                 5666777777777777****************99987766 PP

>> DUF4598  Domain of unknown function (DUF4598)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   2.9    0.0033        30       3     103 ..      34     164 ..      32     188 .. 0.62
   2 ?    3.3   0.1     0.012   1.1e+02      43      66 ..     198     221 ..     172     259 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0033
     DUF4598   3 srlkaFLPqlkaaNkkLekeiaagkvadleidevddd......eeq................yIEMnLgLGvleekrdee................... 60 
                 s   ++L+++++  ++L++++ ++ v ++ +d++d        e+q                 +EM++ +      ++                     
  EFC36722.1  34 STTTEYLGSFQQQKEHLQEDFSTTSVDSVFVDDQDLVdgfaalEQQeaqlmsnlhafvsmysTVEMDILVDQYSLASPTTrtflsldqntspesvvdqv 132
                 566789*******************99999977765545677633345678888888888778999988765555555557887775333333333333 PP

     DUF4598  61 ...sesdsdsssddedsesdekeesakke..kesnvldkllgkksksk 103
                    +              +++k+ s+     + s+ ++k+++k +ks+
  EFC36722.1 133 vigK--------------KSSKDISK--GkfEHSSFVEKRTKKAKKSE 164
                 3321..............11111222..12345555555555544444 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.012
     DUF4598  43 yIEMnLgLGvleekrdeesesdsd 66 
                 + EM+L L v++ kr+++   +sd
  EFC36722.1 198 VKEMELILEVAQTKRRQNGPLNSD 221
                 669**********99988333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (331 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1546  (0.086229); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2121.50
//
Query:       EFC36723.1  [L=529]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.5e-43  146.6   0.0    1.6e-42  145.8   0.0    1.3  1  Pkinase         Protein kinase domain
    2.7e-25   89.1   0.0    5.2e-25   88.2   0.0    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0014   18.6   0.0     0.0023   17.9   0.0    1.2  1  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
       0.03   13.9   0.1       0.08   12.5   0.1    1.6  1  Choline_kinase  Choline/ethanolamine kinase
      0.076   11.8   0.0       0.16   10.7   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  145.8   0.0   4.3e-46   1.6e-42       5     247 ..      39     309 ..      36     314 .. 0.85

  Alignments for each domain:
  == domain 1  score: 145.8 bits;  conditional E-value: 4.3e-46
                 EEEEEESSEEEEEEEETT....TTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.SSEEEEEEE--TTEBHHHHHH........ CS
     Pkinase   5 eklGeGsfGkVykaveke....tgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.kdelylvleyveggeladlle........ 90 
                  +lG+GsfG Vy + e++    +++ vA+K+++ e+   ++ k +++Ei+i++ ++ ++++ l++ +e   +elylv++++e + ++ +++        
  EFC36723.1  39 VELGTGSFGDVYLGEETDpitrKKRDVAIKRVRLERYGPEHFKYLVAEIEIMAGCQNEFVMSLVDKIEIpRKELYLVMDLCEAN-FKYYMNnarkrrqd 136
                 68************98643333899**************999***********************99975899*********77.55555566678765 PP

                 HHSS.--HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTE.................EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHT CS
     Pkinase  91 rkgs.lseeeakkiakqilegleylH.skgiiHrDlKpeNiLidekge.................lKitDFGlakelessskltsfvgtseYlAPEvlk 170
                 ++   lse+e++ ++kqi +gl ylH +k+i+HrD+Kp+N+L+++kg+                 + i+DFGl+k l+s+  ++++ gt+ Y++P +  
  EFC36723.1 137 KRLPlLSEKEIQYWIKQISSGLGYLHlEKKICHRDIKPHNLLLKKKGHevafdfyakignydeytILISDFGLSKVLDSNPIAETILGTQCYRSPQLAL 235
                 3333699*******************8899**************977777888888888888889****************9***************** PP

                 TSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS...-HHHHHHHHHHT-S CS
     Pkinase 171 eneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasei...seeakdllkkllkk 247
                  ++ys  +D+++lGv+l+e+++g  +f ++ ++   + ++ +   i+ +l+ ++ ++   s+    s+e+ dll+ +l+ 
  EFC36723.1 236 FQPYSFDADIFALGVVLFEMIAGYCLFGAQVTNP--KPKYGE---IISTLT-ENIDWSFLSDAldiSPELVDLLSGMLQF 309
                 ****************************555444..333333...555553.46666666654555************97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.2   0.0   1.5e-28   5.2e-25       6     200 ..      40     257 ..      36     273 .. 0.89

  Alignments for each domain:
  == domain 1  score: 88.2 bits;  conditional E-value: 1.5e-28
                  EEEEESSEEEEEEEEETTTTSSEEEEEEEEES.TTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE.SSSSEEEEEE--TTEBHHHHHHHT...... CS
  Pkinase_Tyr   6 klGeGafGkVvegtlkgekekkevkVavKtlk.eeateeekeelleeakimkklkhpnivkllgvct.keepllivteyvkgGdLlkfLrkk...... 95 
                  +lG G+fG+V+ g+ ++  ++k+ +Va+K ++ e++  e+ + l+ e++im  ++++ +++l+  +   +++l++v+++++  +++ ++++       
   EFC36723.1  40 ELGTGSFGDVYLGEETDPITRKKRDVAIKRVRlERYGPEHFKYLVAEIEIMAGCQNEFVMSLVDKIEiPRKELYLVMDLCEA-NFKYYMNNArkrrqd 136
                  79**************999***********96388889999***********************99989999********96.788888877777766 PP

                  .CTTTSBHHHHHHHHHHHHHHHHHHH.HTTEEEST-SGGGEEEEE.................TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-H CS
  Pkinase_Tyr  96 .ekekltlkdllsfalqvAkGmeyLe.skklvHrdlaarNvLlse.................nkvvkisDfGLardiekddeyvkkeeaklpvkWmap 174
                   + + l+ k++  ++ q+++G+ yL+ +kk+ Hrd+   N Ll++                 + ++ isDfGL++ +  d +   +e+      + +p
   EFC36723.1 137 kRLPLLSEKEIQYWIKQISSGLGYLHlEKKICHRDIKPHNLLLKKkghevafdfyakignydEYTILISDFGLSKVL--D-SNPIAETILGTQCYRSP 231
                  4555677788888999*********9667899*****************************999************9..4.4444556677889**** PP

                  HHHHHSEEEHHHHHHHHHHHHHHHHT CS
  Pkinase_Tyr 175 EslkekkftsksDvWsfGvllwEift 200
                       + ++  +D+++ Gv+l+E++ 
   EFC36723.1 232 QLALFQPYSFDADIFALGVVLFEMIA 257
                  ***********************986 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   6.4e-07    0.0023     148     193 ..     142     190 ..     119     195 .. 0.69

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 6.4e-07
                 HHHHHHHHHHHH--S.....SS-EEEE-SS-SGGGEEEC..TTEEEEE--- CS
         APH 148 leeqvlaalaallpg.....elptvllHgDlhpgNllvdpddgrvtGviDf 193
                 l e  ++ + +   +     +l++ ++H+D++p+Nll+++ +++v   +Df
  EFC36723.1 142 LSEKEIQYWIKQISSglgylHLEKKICHRDIKPHNLLLKKKGHEV--AFDF 190
                 3333555555555556667789999**************888988..8888 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   2.2e-05      0.08     106     171 ..     126     190 ..     103     203 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.2e-05
                     .TT..ECHHGGCCHCCCTHHHHHHHHHTHHHHHHCHGG-EEEE-S--SGGGEEE.-CTTEEEE--G CS
  Choline_kinase 106 aqtkakkekkkkqlklinledlekelekleklleelespvvfcHnDlqegNillnkeekklvlIDF 171
                      + +a+k+ ++k+l l++ ++++  ++++ + l +l+ + + cH D+ ++N+ll+k+ +++ + DF
      EFC36723.1 126 YMNNARKRRQDKRLPLLSEKEIQYWIKQISSGLGYLHLEKKICHRDIKPHNLLLKKKGHEVAF-DF 190
                     467788889999999999999************99*******************888777765.55 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   4.5e-05      0.16     319     364 ..     158     215 ..     151     235 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 4.5e-05
  Pkinase_fungal 319 hrsLflkagiLHrDiSenNilitdskke............gerkglLiDLDlakelsd 364
                     +  L+l+++i HrDi  +N+l+  + +e            +e + l++D+ l k l+ 
      EFC36723.1 158 LGYLHLEKKICHRDIKPHNLLLKKKGHEvafdfyakignyDEYTILISDFGLSKVLDS 215
                     557999*****************66555677777778777777888888888877774 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (529 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       828  (0.0461822); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.47
# Mc/sec: 3384.41
//
Query:       EFC36724.1  [L=270]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.063   12.9   2.6       0.11   12.2   2.6    1.3  1  TauE      Sulfite exporter TauE/SafE


Domain annotation for each model (and alignments):
>> TauE  Sulfite exporter TauE/SafE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   2.6   5.9e-06      0.11      91     147 ..      25      84 ..       7      89 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.9e-06
        TauE  91 llkllfgvlllllallmllrkkr...srakgrerrptaillvligglvGllsGllGiGgG 147
                 ++ +++g++ ++l++l+l++++    s+ k+ ++  ++++++ + g++ +++G+  iGgG
  EFC36724.1  25 IFGFIVGFVSIALGVLFLYTPSDysySSSKSDSELFKWAVSAGAFGFCCIIAGYSMIGGG 84 
                 57789999999999999998877777334456788888888888788************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1188  (0.0662614); expected 358.6 (0.02)
Passed bias filter:                      458  (0.0255452); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.25s 00:00:00.76 Elapsed: 00:00:00.42
# Mc/sec: 1909.94
//
Query:       EFC36725.1  [L=820]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      5e-34  117.9   1.7    6.8e-34  117.4   0.3    1.8  2  Pkinase         Protein kinase domain
      1e-31  110.2   0.2    1.5e-31  109.6   0.2    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0075   15.1   0.1      0.011   14.5   0.1    1.2  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.023   14.6   0.0      0.042   13.8   0.0    1.4  1  APH             Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       0.3   1.4e+03     112     133 ..      76      97 ..      73     125 .. 0.86
   2 !  117.4   0.3   1.5e-37   6.8e-34       3     164 ..     649     812 ..     647     814 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.3
                 HHHHHTTEE-SS-SGGGEEEET CS
     Pkinase 112 eylHskgiiHrDlKpeNiLide 133
                 + +H+ g+i+   K eN+Li +
  EFC36725.1  76 RNCHDGGMIYFYTKIENLLIAD 97 
                 679****************983 PP

  == domain 2  score: 117.4 bits;  conditional E-value: 1.5e-37
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS--H CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgslse 97 
                  l+++GeG++G+Vy a+  +++  vA+K++k+++++++ e    +E  ++ +l+hp iv +++v  +++  y+++ey+e+g+l++++       +++  
  EFC36725.1 649 ILKRIGEGGMGVVYHAK--WNRTDVAIKQLKTDSNDEEFE----NEAILMSSLRHPCIVSCFGVSLTTNGKYMIVEYLENGSLEKAIYnskmG-RAILR 740
                 6799************9..9999**********9998776....9****************************************99865422.23555 PP

                 HHHH.HHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS CS
     Pkinase  98 eeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYl 164
                  e+k ki++ +++gl ylHs +   iiHrDlKp N+L+d++ + K++DFGl+k ++++s  +t  vgt  Y+
  EFC36725.1 741 FETKlKILTDVAKGLVYLHSIKphrIIHRDLKPGNLLLDKNMNAKVGDFGLSKIVSNNSAtMTANVGTLLYM 812
                 566669*************865566**************999**************9998899********9 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.6   0.2   3.4e-35   1.5e-31       2     161 ..     648     803 ..     647     812 .. 0.89

  Alignments for each domain:
  == domain 1  score: 109.6 bits;  conditional E-value: 3.4e-35
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ek 97 
                  ++ k++GeG  G V++++++      +++Va+K+lk ++++   ee+ +ea +m++l+hp iv++ gv + ++  ++++ey+++G+L+k + ++   +
   EFC36725.1 648 NILKRIGEGGMGVVYHAKWN------RTDVAIKQLKTDSND---EEFENEAILMSSLRHPCIVSCFGVSLTTNGKYMIVEYLENGSLEKAIYNSkmGR 736
                  67899***************......9********766655...59************************99999**************998884456 PP

                  TTSBHHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEE CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvk 161
                  + l+++++l++ ++vAkG+ yL+s k   ++Hrdl   N Ll++n+ +k++DfGL++ +++++ + +
   EFC36725.1 737 AILRFETKLKILTDVAKGLVYLHSIKphrIIHRDLKPGNLLLDKNMNAKVGDFGLSKIVSNNSATMT 803
                  7899*******************976555****************************9977776644 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.1   2.5e-06     0.011     289     381 ..     728     812 ..     610     815 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 2.5e-06
  Pkinase_fungal 289 rlvispvGkpiekaespkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFm 381
                      +  s +G++i ++e+++++l+ ++  +  + s     +i+HrD   +N+l+      ++ +  + D+ l k +s+  +++     +GTl +m
      EFC36725.1 728 AIYNSKMGRAILRFETKLKILTDVAKGLVYLHSIK-PHRIIHRDLKPGNLLLD-----KNMNAKVGDFGLSKIVSN--NSATMTANVGTLLYM 812
                     4566889*********9888776666666666665.789*************9.....566777889999999995..444456789998888 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   9.3e-06     0.042     164     183 ..     762     781 ..     733     794 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 9.3e-06
                 S-EEEE-SS-SGGGEEEC.. CS
         APH 164 lptvllHgDlhpgNllvdpd 183
                  p++++H+Dl+pgNll+d++
  EFC36725.1 762 KPHRIIHRDLKPGNLLLDKN 781
                 6899**************44 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (820 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       908  (0.0506442); expected 358.6 (0.02)
Passed bias filter:                      533  (0.0297284); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.82u 0.31s 00:00:01.12 Elapsed: 00:00:00.50
# Mc/sec: 4921.71
//
Query:       EFC36726.1  [L=1200]
Description: pyruvate carboxylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-78  262.7   0.2    3.4e-78  262.0   0.2    1.4  1  CPSase_L_D2      Carbamoyl-phosphate synthase L chain, ATP bi
    1.5e-56  191.3   0.3    5.8e-55  186.1   0.2    2.8  2  PYC_OADA         Conserved carboxylase domain
    2.2e-40  137.6   0.0    4.3e-40  136.7   0.0    1.5  1  Biotin_carb_N    Biotin carboxylase, N-terminal domain
    3.2e-33  114.1   0.0    2.9e-31  107.8   0.0    2.6  2  Biotin_carb_C    Biotin carboxylase C-terminal domain
    2.8e-30  105.8   0.0    9.2e-30  104.1   0.0    1.9  2  HMGL-like        HMGL-like
    6.9e-17   61.1   3.8    1.6e-16   59.9   3.8    1.7  1  Biotin_lipoyl    Biotin-requiring enzyme
    8.9e-10   38.4   0.1    2.3e-09   37.1   0.1    1.6  1  ATP-grasp        ATP-grasp domain
    1.6e-09   37.4   3.8    3.4e-05   23.6   0.5    2.6  2  Biotin_lipoyl_2  Biotin-lipoyl like
    1.5e-08   34.4   0.0    2.7e-08   33.6   0.0    1.4  1  Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
      0.001   19.1   0.0     0.0025   17.9   0.0    1.7  1  ATP-grasp_3      ATP-grasp domain
     0.0028   16.9   0.2       0.42    9.8   0.0    2.7  3  HlyD_D23         Barrel-sandwich domain of CusB or HlyD membr
     0.0048   16.2   0.0       0.01   15.1   0.0    1.5  1  ATPgrasp_ST      Sugar-transfer associated ATP-grasp
  ------ inclusion threshold ------
      0.014   15.0   0.1      0.035   13.7   0.1    1.7  1  ATP-grasp_4      ATP-grasp domain
      0.081   12.6   1.4        5.3    6.8   0.1    2.9  2  PYNP_C           Pyrimidine nucleoside phosphorylase C-termin
      0.095   11.6   0.0       0.16   10.9   0.0    1.3  1  DUF3182          Protein of unknown function (DUF3182)
       0.11   13.3   0.2         16    6.3   0.0    3.7  2  HlyD_3           HlyD family secretion protein
       0.11   12.3   0.4       0.72    9.6   0.0    2.4  3  ATPgrasp_Ter     ATP-grasp in the biosynthetic pathway with T
       0.19   11.5   0.8       0.82    9.4   0.2    2.4  3  PTS_EIIA_1       phosphoenolpyruvate-dependent sugar phosphot


Domain annotation for each model (and alignments):
>> CPSase_L_D2  Carbamoyl-phosphate synthase L chain, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  262.0   0.2   3.5e-81   3.4e-78       1     210 [.     182     391 ..     182     392 .. 0.99

  Alignments for each domain:
  == domain 1  score: 262.0 bits;  conditional E-value: 3.5e-81
                  SHHHHHHHHHHTT-BBSSEECSSBSSHHHHHHHHHHH-SSEEEEETTCCTTTTEEEESSHHHHHHHHHHHHHHHHHHHSTS-EEEEE--SSSEEEEEE CS
  CPSase_L_D2   1 DkesakealkkinvpvvpssaapvetleealaiakeigyPviikaafglGGkGmrvarneeelaelvkkalaeakaafgnkqvlvekslkgpkeiEve 98 
                  Dk++a++ + +i++pvvp+++++v+++ ea ++ ++i++Pvi+kaa+g+GG+Gmrv+++ e+l+e++++a++ea  afg++ +++ek++++p++iEv+
   EFC36726.1 182 DKTRARKVATDIGIPVVPGTPTAVTSIAEAKTFCSQISFPVILKAAMGGGGRGMRVVSKMEDLEEAFQRASSEALNAFGSSAIFIEKFVEKPRHIEVQ 279
                  99************************************************************************************************ PP

                  EEEETTS-EEEEEEEEECCECTCCCCEEEES-SS--HHHHHHHHHHHHHHHHHHT-EEEEEEEEEEETTTTEEEEEEEESS--CCHHHHHHHHS--HH CS
  CPSase_L_D2  99 vlrDakgnvitvcerenslqlrtqkvievAPsqtLtdeerqalreaavkvvrevgvvgagtveflldpkskeyyviEvNtRlsvesalaekaTGldlv 196
                  +l+D+ gnv+++ er++s+q+r+qkv+e+AP++ L+++ r+++ ++av+++r+v++++agt+efl+d++ k+yy+iEvN+Rl+ve++++e++TG+d+v
   EFC36726.1 280 ILADKFGNVVHLYERDCSVQRRHQKVVEIAPAPHLNPQVREKILADAVRLARHVKYQNAGTFEFLVDSNGKDYYFIEVNPRLQVEHTVTEEITGVDIV 377
                  ************************************************************************************************** PP

                  HHHHHHHTT--GCG CS
  CPSase_L_D2 197 keaakialgekLee 210
                    ++ ia g++L+e
   EFC36726.1 378 RSQILIAEGKSLDE 391
                  ************97 PP

>> PYC_OADA  Conserved carboxylase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.19   1.9e+02      94     153 ..     563     628 ..     562     634 .. 0.78
   2 !  186.1   0.2   5.8e-58   5.8e-55       1     198 []     893    1082 ..     893    1082 .. 0.95

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.19
                 --SS---HHHHHHHHT.......-----S-GGGG---.-HHHHHHHTTTTSSSHHHHHHHHHSHHH CS
    PYC_OADA  94 kppggfpeelvkkvlk......geepitsrpadslepedleklrkeleekakteedvlsyalypkv 153
                 k+p g p+  +k+vl+        ++i  r + ++ +  ++ ++++l +     +d++s a y + 
  EFC36726.1 563 KTPTGAPPRGWKQVLDeqgpeaFAKAIRDRSELLITDTTMRDAHQSLLATRVRTRDLMSIAPYTAH 628
                 5778888888888886332223345589999999***99**9999999999999999999998765 PP

  == domain 2  score: 186.1 bits;  conditional E-value: 5.8e-58
                  HHCCT--CCHHHHHHHHHHH.TT-GGGHHHHHHHHHHHHHHTT----STTHHHHHHHHHHHHHHH........TS.TTSS--HHHHHHHTTSS---S CS
    PYC_OADA    1 VykheiPGGqltnlkeqake.qglldkfeevlkeyaevnkllGdivkVTPsSkvvgdlAvfnvlnklteedvleegrykdipdsvvdllkGelGkpp 96  
                  Vy+heiPGGq+tnl+ q+ + +g ld f++v++ y+ +n+llGdi+kVTPsSkvvgdlA+f+v+n+l e+dv+e+      +d++      +lG p+
  EFC36726.1  893 VYVHEIPGGQYTNLNAQVYSiNGSLDGFPKVKESYEIANRLLGDIIKVTPSSKVVGDLAQFMVQNNLAEKDVIEK------ADQF------KLGIPY 977 
                  8*****************984689*****************************************9999999998......3444......59**** PP

                  S---HHHHHHHHT.-----S-GGGG---.-HHHHHHHTTTTSS...SHHHHHHHHHSHHHHHHHHHHHHHHHHHH..CTTTS......-SEEEEEET CS
    PYC_OADA   97 ggfpeelvkkvlkgeepitsrpadslepedleklrkeleekak...teedvlsyalypkvaekflkfreeygdvsvlptkvffeglkvgeeveveve 190 
                  ggfpe+l++kv++g+  i++rp++s+++ d+ kl+++l++ ++   +eed++s  l+pkv+e++++f+++yg+v++l t+++f+g kvgee+eve+e
  EFC36726.1  978 GGFPEPLRTKVMRGKPSIEGRPGASMPDFDFVKLKDKLKKDLDydaSEEDLISSSLFPKVFEEYVQFKQQYGEVTNLGTRQYFKGIKVGEETEVELE 1074
                  ****************************************99555699************************************************* PP

                  TEEEE.EE CS
    PYC_OADA  191 ggkylivk 198 
                  +gk+l++k
  EFC36726.1 1075 KGKVLHIK 1082
                  ***99875 PP

>> Biotin_carb_N  Biotin carboxylase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  136.7   0.0   4.3e-43   4.3e-40       2     109 ..      66     176 ..      65     177 .. 0.95

  Alignments for each domain:
  == domain 1  score: 136.7 bits;  conditional E-value: 4.3e-43
                    --EEEE---HHHHHHHHHHHHHTT-EEEEEEEGGGTTSHHHHHSSEEEEEESSTTC...CGGG-HHHHHHHHHHTT-SEEE--SSTTTT-HHHHHH CS
  Biotin_carb_N   2 ikkvlianrGeiAvriiravrelgietvavyseedanslhvreadeavelgpasas...esYlniekivkaakesgadavhpGyGflsEnaefaea 94 
                    ++k+l+anrGeiA+ri+r+++e+g++tv +y+++da+s h  +ade++ +g++++    e+Yl+i++i+k+ake+g+da+hpGyGflsE+a+fa+a
     EFC36726.1  66 FEKLLVANRGEIATRILRSAHEIGCRTVSIYAKQDASSVHRYKADESYLIGKDKELgpvEAYLSIDEIIKIAKENGVDAIHPGYGFLSERADFARA 161
                    79*************************************************88754444************************************* PP

                    HHHTT-EESSS-HHH CS
  Biotin_carb_N  95 veeagivfiGPsaea 109
                    ++e+gi fiGP+a++
     EFC36726.1 162 CSENGIQFIGPTADV 176
                    ************987 PP

>> Biotin_carb_C  Biotin carboxylase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.8   0.0   2.9e-34   2.9e-31       1     107 [.     407     514 ..     407     515 .. 0.97
   2 ?    3.4   0.0     0.082        81       8      56 ..    1129    1183 ..    1121    1190 .. 0.81

  Alignments for each domain:
  == domain 1  score: 107.8 bits;  conditional E-value: 2.9e-34
                    EEEEESEETTTTTEE--CE-SEEE---STTEEEEE--.-TT-EE-TTS-SEEEEEEEEESSHHHHHHHHHHHHHT-EEESS-BSHHHHHHHHH-HH CS
  Biotin_carb_C   1 eaRinaEdpeknflpssGkvtelelpegpgvRvdsgv.eegsevspyyDsllaKlivhgetreealarlrraLaelrieGvktnieflrailedee 95 
                    ++R+++Edp ++f+p++G ++++++ eg+g+R+d g  + gs+++p+yDsll K+i +g t+eea ++lrraLae+ri+Gvk+ni+fl+++l++e+
     EFC36726.1 407 QCRVTTEDPLNGFQPDTGVLEAFRTGEGMGIRLDIGSgYVGSKITPFYDSLLVKVIGKGLTHEEASNKLRRALAEFRIRGVKHNIPFLQKVLSHEK 502
                    79********************************886269******************************************************** PP

                    HHHT---TTTCC CS
  Biotin_carb_C  96 fakgeldtkfle 107
                    f +g +dt+f++
     EFC36726.1 503 FLNGYVDTSFID 514
                    ***********8 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.082
                     ETTTTTEE--CE-SEEE--......-STTEEEEE---TT-EE-TTS-SEEEEEEE CS
  Biotin_carb_C    8 dpeknflpssGkvtelelp......egpgvRvdsgveegsevspyyDsllaKliv 56  
                     dp++  +p +Gkv  ++++      +g  + v s+++ +++v+ ++D ++  l v
     EFC36726.1 1129 DPNEIGAPMPGKVIDIKVKegdkvkKGDTLLVQSAMKMETQVKCNFDGIIKSLGV 1183
                     8888889**********996666667777779999999999999**999987755 PP

>> HMGL-like  HMGL-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       6.4   6.4e+03     144     168 ..      74      98 ..      34     112 .. 0.65
   2 !  104.1   0.0   9.2e-33   9.2e-30       3     263 ..     596     869 ..     594     869 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 6.4
                 -HHHHHHHHHHHHHHT-SEEEEEET CS
   HMGL-like 144 dleflaevveaaeeaGatriniaDt 168
                   e +++++  a e+G+++++i + 
  EFC36726.1  74 RGEIATRILRSAHEIGCRTVSIYAK 98 
                 4556778888888999999988665 PP

  == domain 2  score: 104.1 bits;  conditional E-value: 9.2e-33
                 EEEE-TTTHHHHTS.SS---HHHHHHHHHHHHHHT-SEE--..........TSGGGT.THHHHHHHS---TT-B...........--EE-SSHHHHHHH CS
   HMGL-like   3 kivdttLRDGeqal.kaalsveeklaiakaLdeagvdeiEv..........gfpaaseddfevvraiakavkka......r...ilalvrarekdikaa 81 
                  i+dtt+RD++q+l ++++++ + + ia   ++a  d + +          +  ++ e +fe++ ++ +a+++       r    +++  + ++++ + 
  EFC36726.1 596 LITDTTMRDAHQSLlATRVRTRDLMSIAPYTAHAMSDCLSLemgggatfdvCLNFLRECPFERLAKLREAIPNIpfqmlfRganAVGYTAYPDNVVYKY 694
                 599**********99************988888877754444499999999************999999998886666662556889999999999888 PP

                 HH....TT-SEEEEEEES-HHHHHHHHSSTHHHHHHHHHHHHHHHHHTT-ETTT-BTTTBS--HHHHHHHHHHHHHHT-SEEEEEETTS---HHHHHHH CS
   HMGL-like  82 vealkgagakrvhvfiatselhlkaklkkdreevakkaeeavkaarslgkdvelsledasrtdleflaevveaaeeaGatriniaDtvGvltPneaael 180
                  ++ ++ g++++++f++ +    +++l++d+   + +a  +++aa s++ d  +s +  s+ +le+ ++v+  ++e G+ ++ i+D+ G+l P++a  l
  EFC36726.1 695 CKKTVEHGMDIFRIFDSLNY-VPNMELGIDA---VGSAGGVIEAAISYTGD--VSDPKKSKYNLEYYLKVARSLVEKGVHILCIKDMAGLLRPSAATLL 787
                 888888************99.7788888875...67788999999999987..58999***************************************** PP

                 HHHHHHHS-.GGGEEEEEB-TTS-HHHHHHHHHHTT--EEEEBTTS--SSBBB-BHHHHHHHHHHTT-B----HHHHHHHHHH CS
   HMGL-like 181 isalkervkdkvilsvHcHndlGlAvantlaAveaGadrvdgtvnGlGeraGnaaleelvaalealgvdtgldlqklrsiaal 263
                 i al+++ + ++++++H+H++ G++va +laA+eaGad vd+++ ++++ +  ++l ++va l+++++dt+ldl kl +++++
  EFC36726.1 788 IGALRKEFP-HIPIHLHTHDTAGTGVATLLAAAEAGADIVDAAIDSMSGLTSQPSLGAIVASLKNTPLDTKLDLGKLSKVSDY 869
                 *********.*********************************************************************9985 PP

>> Biotin_lipoyl  Biotin-requiring enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.9   3.8   1.6e-19   1.6e-16       2      72 ..    1132    1197 ..    1131    1198 .. 0.97

  Alignments for each domain:
  == domain 1  score: 59.9 bits;  conditional E-value: 1.6e-19
                     EEEESSSEEEEEE.ECSESSSTTCEE-TTSEEEEEECTTEEEEEEBSSSEEEEEESSTTTEEE-TTCEEEE CS
  Biotin_lipoyl    2 eiksPmiGesveegvvevlvkvGdkVkagqvlaeveamKmemeieapkaGvvkeilvkeGdtvevgdllak 72  
                     ei +Pm+G+++      ++vk+GdkVk+g++l++ +amKme++++   +G++k++ vk+Gd+v+ gdll++
     EFC36726.1 1132 EIGAPMPGKVID-----IKVKEGDKVKKGDTLLVQSAMKMETQVKCNFDGIIKSLGVKVGDEVQGGDLLCI 1197
                     899*********.....***************************************************986 PP

>> ATP-grasp  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   0.1   2.3e-12   2.3e-09      13     159 ..     204     360 ..     191     365 .. 0.90

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 2.3e-12
                 EECCHHHHHHHHHHH-SCEEEEESSS-CTTTTEEEECTCCGHHCHHHHC........GTTCEEEEE----SEEEEEEEEEETTC-.EEE--EEEEEEET CS
   ATP-grasp  13 aveskeeleeaaeelglpvvvKarrlgydGkGqsvvrseedleqaleal........keekvivEefvpfekElsvlvvrsaeGe.tafypvvetvqed 102
                 av+s +e++ +++++ +pv++K + +g  G+G  vv + edle+a++ +        ++  + +E+fv+  + + v +  ++ G+ ++ y+    vq++
  EFC36726.1 204 AVTSIAEAKTFCSQISFPVILK-AAMGGGGRGMRVVSKMEDLEEAFQRAssealnafGSSAIFIEKFVEKPRHIEVQILADKFGNvVHLYERDCSVQRR 301
                 688899****************.89999******************99999999999999***********9999999999999957899999999999 PP

                 TEEEEEEECEE-.SCHHHHHHHHHHHHHHHHHTSSEEEEEEEEEETTCT.EEEEEEESS CS
   ATP-grasp 103 gilrlsvapaev.sekaqkkaeeiakkiveeLggvGvfavElFvledge.llvnElapR 159
                    ++ +apa++ + +  +k+ + a ++++++ +    ++E+ v ++g+  ++ E+ pR
  EFC36726.1 302 HQKVVEIAPAPHlNPQVREKILADAVRLARHVKYQNAGTFEFLVDSNGKdYYFIEVNPR 360
                 99999999987615568899999999*******************9999999*****99 PP

>> Biotin_lipoyl_2  Biotin-lipoyl like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   0.5   3.4e-08   3.4e-05       5      31 ..    1133    1159 ..    1130    1171 .. 0.90
   2 !   14.4   0.4   2.5e-05     0.025       4      33 ..    1169    1198 ..    1161    1200 .] 0.89

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 3.4e-08
  Biotin_lipoyl_2    5 IaapvsGrVaqlnVkdGqrVkaGdvLa 31  
                       I ap +G+V  + Vk+G+ Vk+Gd+L+
       EFC36726.1 1133 IGAPMPGKVIDIKVKEGDKVKKGDTLL 1159
                       77999********************98 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 2.5e-05
  Biotin_lipoyl_2    4 sIaapvsGrVaqlnVkdGqrVkaGdvLael 33  
                       +++  ++G +++l Vk G++V+ Gd+L + 
       EFC36726.1 1169 QVKCNFDGIIKSLGVKVGDEVQGGDLLCIV 1198
                       677778********************9875 PP

>> Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.6   0.0   2.7e-11   2.7e-08       4     174 ..     192     359 ..     189     360 .. 0.82

  Alignments for each domain:
  == domain 1  score: 33.6 bits;  conditional E-value: 2.7e-11
                      HTT--B--EEEEETTHHCH-H-HHHHHHHHHC-SSEEEEESSSSTTTTEEEESSGGGHHHHHHHHHTT......-SCEEEEE--.ESEEEEEEE CS
  Dala_Dala_lig_C   4 aaGlpvvpyvvlekeeakeekkellekveeelgypvfVKpareGSSvGvskveseeelkeaieeafky......dekvlvEeai.egreievav 90 
                      + G+pvvp ++    ++ e+k       ++++++pv+ K+a  G   G+  v+ +e+l+ea+++a +        + +++E+++ + r iev +
       EFC36726.1 192 DIGIPVVPGTPTAVTSIAEAK-----TFCSQISFPVILKAAMGGGGRGMRVVSKMEDLEEAFQRASSEalnafgSSAIFIEKFVeKPRHIEVQI 280
                      567777777666666666666.....8999********************************9998762222234689******999******* PP

                      EETSSCEEEEEEEEE-SSSSS-HHHHHC.TT-EEESS----HHHHHHHHHHHHHHHHHTT--SEEEEEEEEETTTE.EEEEEEES CS
  Dala_Dala_lig_C  91 lgneklevsevgeivvkkgfydyeakysddkaqlevpaklekeveekiqelalkaykaldlrGlaRvDfflteege.ivlnEvNt 174
                      l +   +v ++ e+  +    + ++k     +++    +l+++v+eki + a++  + ++ +  +   f+++++g+  ++ EvN+
       EFC36726.1 281 LADKFGNVVHLYERDCSV--QRRHQKV----VEIAPAPHLNPQVREKILADAVRLARHVKYQNAGTFEFLVDSNGKdYYFIEVNP 359
                      **8888888888776654..3445554....68888889********************************99996478999996 PP

>> ATP-grasp_3  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   2.5e-06    0.0025      28     159 ..     216     362 ..     181     364 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.5e-06
                  S--SSSEEEEESS-------B--SS--TTE...................EEEE---.SEEEEEEEEE.SSSEEEEEEEEEEEET....TEEEEEEES- CS
  ATP-grasp_3  28 eeeekklvvKprdGaggesvrvveekeeaeaaieeve............lvqefie.GkplSvsllsdgekvlvlavnrqliekaekefvyaGnvtpi 112
                  ++   ++++K + G+gg ++rvv + e++e+a++  +             + +f+e  +++ v++l+d+  ++v    r    +++++ v   +++p+
   EFC36726.1 216 SQISFPVILKAAMGGGGRGMRVVSKMEDLEEAFQRASsealnafgssaiFIEKFVEkPRHIEVQILADKFGNVVHLYERDCSVQRRHQKVV--EIAPA 311
                  4457799**********************99999888899********98999**84599*******998877766666665444444444..44555 PP

                  ---H...HHHHHHHHHHHHTTST.T--EEEEEEEEESS...SEEEEEEESS-- CS
  ATP-grasp_3 113 etel...keevvelaeevvekle.glaGyvGvDlvlkd..eepyviEvNPRlt 159
                  ++ +   +e++ + a ++ ++++ + aG    ++++    ++ y+iEvNPRl+
   EFC36726.1 312 PHLNpqvREKILADAVRLARHVKyQNAGT--FEFLVDSngKDYYFIEVNPRLQ 362
                  44333369999999*******96444444..566655445999********97 PP

>> HlyD_D23  Barrel-sandwich domain of CusB or HlyD membrane-fusion
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       4.7   4.7e+03      78     140 ..     248     309 ..     238     313 .. 0.78
   2 !    9.8   0.0   0.00042      0.42     103     137 ..    1125    1159 ..    1083    1166 .. 0.72
   3 ?    4.5   0.0     0.017        17      20      49 ..    1168    1196 ..    1160    1200 .] 0.60

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4.7
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    HlyD_D23  78 lleaarerLrllgvseeqiaelektgkvqktvtvkapisGvVteknvreGqyvqpgdtlftia 140
                   +a++e L+++g s+  i++  ++ +   +v++ a   G V+++  r+ ++ +  +++++ia
  EFC36726.1 248 FQRASSEALNAFGSSAIFIEKFVEKPRH-IEVQILADKFGNVVHLYERDCSVQRRHQKVVEIA 309
                 5578888899999999999998766554.4589999999999999988888888888888887 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00042
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    HlyD_D23  103 gkvqktvtvkapisGvVteknvreGqyvqpgdtlf 137 
                   + +   ++ ap+ G V++ +v eG+ v++gdtl+
  EFC36726.1 1125 ANKKDPNEIGAPMPGKVIDIKVKEGDKVKKGDTLL 1159
                  33344456777777777777777777777777775 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.017
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    HlyD_D23   20 arvsarveGwveklyvnatgdkVkkGqpLa 49  
                  ++v+ +++G +++l v+ +gd+V+ G+ L 
  EFC36726.1 1168 TQVKCNFDGIIKSLGVK-VGDEVQGGDLLC 1196
                  45566666666666666.666666666654 PP

>> ATPgrasp_ST  Sugar-transfer associated ATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   1.1e-05      0.01      16      97 ..     177     256 ..     168     268 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.1e-05
  ATPgrasp_ST  16 fplvddKlkfkelalraglkvpkllgvikeqaeiseleafvkeleegvviKpakgsgGkGilviteredqdylkssgksall 97 
                  ++ + dK   +++a + g++v    g+     +i+e++ f++++   v++K+a g gG+G++v++++ed +   + + s  l
   EFC36726.1 177 VESFGDKTRARKVATDIGIPVVP--GTPTAVTSIAEAKTFCSQISFPVILKAAMGGGGRGMRVVSKMEDLEEAFQRASSEAL 256
                  56799********9998888766..8999999************777*****************999987665555555544 PP

>> ATP-grasp_4  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   3.5e-05     0.035       1     151 [.     218     360 ..     218     369 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.5e-05
  ATP-grasp_4   1 islPvviKPsvgffSlGVykinneeewkaavaaieeeleqakeeykeevveeesflvEeyieG.eEfavdayfdeeGepvilnilkkefaseedvsdr 97 
                  is+Pv++K ++g + +G++++++ e++++a+++ ++e+       +  +  ++ + +E+++e    + v ++ d+ G+   +++++++ + ++  +++
   EFC36726.1 218 ISFPVILKAAMGGGGRGMRVVSKMEDLEEAFQRASSEA------LN--AFGSSAIFIEKFVEKpRHIEVQILADKFGNV--VHLYERDCSVQRRHQKV 305
                  689*****************************999762......22..3456788999999862568899999999874..46677888888888888 PP

  ATP-grasp_4  98 lyvtsa.kvieetlealeellkevnallglknfpvHiElrvsedg.kiipiEvnpl 151
                  + + +a ++  +  e++     +++++++ +n  + +E+ v+ +g + + iEvnp+
   EFC36726.1 306 VEIAPApHLNPQVREKILADAVRLARHVKYQNAGT-FEFLVDSNGkDYYFIEVNPR 360
                  87776525667777777666666666777766554.68888888867888999986 PP

>> PYNP_C  Pyrimidine nucleoside phosphorylase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.1    0.0053       5.3      34      51 ..    1142    1159 ..    1137    1165 .. 0.92
   2 ?    3.2   0.1     0.067        67      36      52 ..    1181    1197 ..    1177    1198 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0053
                  EEES--TT-EEBTTSEEE CS
      PYNP_C   34 ielhkklGdkVkkGepla 51  
                  i++++k GdkVkkG++l+
  EFC36726.1 1142 IDIKVKEGDKVKKGDTLL 1159
                  78899***********97 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.067
                  ES--TT-EEBTTSEEEE CS
      PYNP_C   36 lhkklGdkVkkGeplat 52  
                  l +k+Gd+V+ G+ l+ 
  EFC36726.1 1181 LGVKVGDEVQGGDLLCI 1197
                  668**********9986 PP

>> DUF3182  Protein of unknown function (DUF3182)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00017      0.16     135     176 ..     219     260 ..     184     278 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00017
     DUF3182 135 egkvRlKeveatgGrgQrvvedaaeldaaLaaldeeelaaeG 176
                 + +v lK++++ gGrg rvv++ ++l++a ++ ++e+l+a G
  EFC36726.1 219 SFPVILKAAMGGGGRGMRVVSKMEDLEEAFQRASSEALNAFG 260
                 45899*********************************9998 PP

>> HlyD_3  HlyD family secretion protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.0     0.016        16       2      28 ..    1133    1159 ..    1132    1166 .. 0.92
   2 ?    2.3   0.0      0.28   2.8e+02       3      27 ..    1171    1195 ..    1169    1199 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.016
      HlyD_3    2 lrApvdGvvvelnveegevvqagdell 28  
                  + Ap  G+v +++v+eg+ v +gd+ll
  EFC36726.1 1133 IGAPMPGKVIDIKVKEGDKVKKGDTLL 1159
                  569**********************98 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.28
      HlyD_3    3 rApvdGvvvelnveegevvqagdel 27  
                  +  +dG++++l v++g+ vq gd l
  EFC36726.1 1171 KCNFDGIIKSLGVKVGDEVQGGDLL 1195
                  5579******************987 PP

>> ATPgrasp_Ter  ATP-grasp in the biosynthetic pathway with Ter operon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00072      0.72      42     126 ..     315     402 ..     276     405 .. 0.73
   2 ?   -1.7   0.0       2.3   2.3e+03       9      30 ..     713     735 ..     712     761 .. 0.84
   3 ?   -2.5   0.0         4     4e+03      90     112 ..     815     837 ..     813     850 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00072
  ATPgrasp_Ter  42 elekdeelielaerlaeefgldglvnvQvrededg..pkLLEiNpRasGGlgys.alaGvnlpylalklllgleteeveepeeglrvr 126
                   + + +e+++  a rla++++ +    + +  d +g  ++ +E+NpR +    ++   +Gv++++  +  + g++ +e+  ++e+++vr
    EFC36726.1 315 NPQVREKILADAVRLARHVKYQNAGTFEFLVDSNGkdYYFIEVNPRLQVEHTVTeEITGVDIVRSQILIAEGKSLDEIGLKQESISVR 402
                   44567888888999999887776666666555554459**********8766662578**************9999999999988886 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 2.3
  ATPgrasp_Ter   9 eyLegpEySvDvlaekgevl.aa 30 
                   +y ++ E  +D +  +g v+ aa
    EFC36726.1 713 NYVPNMELGIDAVGSAGGVIeAA 735
                   6999**********988887344 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 4
  ATPgrasp_Ter  90 lgysalaGvnlpylalklllgle 112
                   l  +a aG++++++a++ + gl 
    EFC36726.1 815 LLAAAEAGADIVDAAIDSMSGLT 837
                   5567899**********999963 PP

>> PTS_EIIA_1  phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       7.5   7.5e+03      16      41 ..     922     947 ..     912     951 .. 0.71
   2 ?    9.4   0.2   0.00083      0.82      79     108 ..    1137    1166 ..    1134    1178 .. 0.84
   3 ?   -1.9   0.0       2.7   2.7e+03      86     102 ..    1181    1197 ..    1168    1199 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 7.5
                 GSSSHH.HHT-TTSEEEEEEE-SSEEE CS
  PTS_EIIA_1  16 evpDev.faekmlGdGvaiepsegkvv 41 
                 +v++    a+++lGd + ++ps+ kvv
  EFC36726.1 922 KVKESYeIANRLLGDIIKVTPSS-KVV 947
                 56665557899999999999976.554 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00083
                  TTTTTEEES----SEE-SEEEEEEE-HHHH CS
  PTS_EIIA_1   79 lkgegFellvkegdkVkagdklvevdleai 108 
                  + g++ +++vkegdkVk+gd+l+  +  ++
  EFC36726.1 1137 MPGKVIDIKVKEGDKVKKGDTLLVQSAMKM 1166
                  568999***************987666555 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2.7
                  ES----SEE-SEEEEEE CS
  PTS_EIIA_1   86 llvkegdkVkagdklve 102 
                  l vk gd+V+ gd+l+ 
  EFC36726.1 1181 LGVKVGDEVQGGDLLCI 1197
                  56999********9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       594  (0.0331307); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              18  [number of targets reported over threshold]
# CPU time: 0.97u 0.34s 00:00:01.31 Elapsed: 00:00:00.53
# Mc/sec: 6761.59
//
Query:       EFC36727.1  [L=188]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (188 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       616  (0.0343577); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1186.93
//
Query:       EFC36728.1  [L=2352]
Description: basal body protein NBP-1 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.4e-50  166.7 319.7    0.00011   22.5   9.9   19.0 19  EGF_2           EGF-like domain
    1.5e-49  168.8   2.5    2.3e-49  168.2   2.5    1.3  1  Pkinase         Protein kinase domain
    3.6e-30  105.1   0.5    6.1e-30  104.4   0.5    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    1.5e-07   31.1   0.0        4.4    7.5   0.0    5.8  5  NHL             NHL repeat
    0.00018   21.4   0.4    0.00054   19.9   0.4    1.8  1  TMEM154         TMEM154 protein family
     0.0004   20.4   3.2     0.0012   18.9   3.2    1.8  1  RIFIN           Rifin
  ------ inclusion threshold ------
      0.051   12.3   0.1      0.096   11.4   0.1    1.3  1  Pkinase_fungal  Fungal protein kinase
      0.072   13.9   0.2       0.84   10.5   0.0    2.8  2  Corona_NSP4_C   Coronavirus nonstructural protein 4 C-terminu


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.3       7.9   1.8e+04      22      28 ..     332     338 ..     332     338 .. 0.88
   2 !   10.7  11.4   0.00023      0.52       8      32 .]     359     382 ..     350     382 .. 0.86
   3 !   11.0  13.6   0.00019      0.42       6      32 .]     394     421 ..     387     421 .. 0.90
   4 !   12.1   6.1   8.4e-05      0.19       6      32 .]     435     460 ..     431     460 .. 0.90
   5 !   18.3  10.8     1e-06    0.0022       5      32 .]     473     499 ..     469     499 .. 0.90
   6 !   12.9  12.6   4.7e-05      0.11       3      32 .]     510     538 ..     504     538 .. 0.86
   7 !   16.7   8.7   3.2e-06    0.0072       5      32 .]     551     577 ..     548     577 .. 0.86
   8 !   12.1   8.7   8.3e-05      0.19       8      32 .]     593     618 ..     587     618 .. 0.80
   9 !   13.7   8.8   2.6e-05     0.059       4      32 .]     630     658 ..     627     658 .. 0.91
  10 !   18.6   7.9   8.1e-07    0.0018       5      32 .]     671     698 ..     667     698 .. 0.89
  11 !   22.5   9.9   4.8e-08   0.00011       7      32 .]     714     738 ..     708     738 .. 0.91
  12 !   22.4   9.7   5.3e-08   0.00012       4      32 .]     750     777 ..     746     777 .. 0.88
  13 !   13.1   8.3   4.1e-05     0.092       6      32 .]     791     816 ..     787     816 .. 0.87
  14 !   10.3   9.7   0.00032      0.71       6      32 .]     830     855 ..     825     855 .. 0.85
  15 !   20.3   9.0   2.4e-07   0.00053       5      32 .]     868     894 ..     863     894 .. 0.92
  16 !   13.8  12.2   2.6e-05     0.057       4      32 .]     906     933 ..     899     933 .. 0.87
  17 !   16.2   9.9   4.5e-06      0.01       5      32 .]     946     972 ..     942     972 .. 0.89
  18 !   17.1  12.6   2.4e-06    0.0055       4      32 .]     984    1011 ..     977    1011 .. 0.88
  19 !   18.7   7.9   7.4e-07    0.0017       4      32 .]    1022    1050 ..    1020    1050 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 7.9
       EGF_2  22 dCdsgyq 28 
                 +Cdsgyq
  EFC36728.1 332 YCDSGYQ 338
                 6****97 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00023
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 C++hG+C +++  C Cd+gy+  +C
  EFC36728.1 359 CSNHGSCTSPN-TCTCDTGYTLSDC 382
                 ********999.9*******96666 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00019
       EGF_2   6 eiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+g  +GtC ++   C+C++g++G +C
  EFC36728.1 394 TACSGanQGTCSAPD-TCQCKNGFSGSDC 421
                 6799999*****999.9************ PP

  == domain 4  score: 12.1 bits;  conditional E-value: 8.4e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g GtC +++  C+C++ y G  C
  EFC36728.1 435 GVCSGKGTCSAPE-TCSCQTDYVGSVC 460
                 57***********.9*********988 PP

  == domain 5  score: 18.3 bits;  conditional E-value: 1e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g+GtC +++  C+C+++y+G +C
  EFC36728.1 473 PNVCSGGGTCTSPN-SCQCFTNYSGTQC 499
                 478********999.7************ PP

  == domain 6  score: 12.9 bits;  conditional E-value: 4.7e-05
       EGF_2   3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++++ C+g+G+C +  ++C C ++++G +C
  EFC36728.1 510 TNSNVCSGRGSCAK-YNNCTCTANFFGSNC 538
                 44899*******84.558************ PP

  == domain 7  score: 16.7 bits;  conditional E-value: 3.2e-06
       EGF_2   5 deiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                  ++C  hG C+  + ++C Cds+y+G +C
  EFC36728.1 551 ASTCASHGRCD--GyNKCTCDSNYFGLDC 577
                 679********..6459***********9 PP

  == domain 8  score: 12.1 bits;  conditional E-value: 8.3e-05
       EGF_2   8 Cgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 C    +GtC++ + +C C ++y+G +C
  EFC36728.1 593 CTApnRGTCNSYN-NCTCTNSYYGTQC 618
                 55555*****555.8************ PP

  == domain 9  score: 13.7 bits;  conditional E-value: 2.6e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 +++ C+g G C +++  C C ds+y+G +C
  EFC36728.1 630 NSSVCSGKGACSAPN-TCLCsDSNYSGSNC 658
                 4789********999.9************* PP

  == domain 10  score: 18.6 bits;  conditional E-value: 8.1e-07
       EGF_2   5 deiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g +G C++++  C+C+s+y+G++C
  EFC36728.1 671 SRVCSGsRGACNSPN-TCSCFSNYFGPQC 698
                 678*********999.9************ PP

  == domain 11  score: 22.5 bits;  conditional E-value: 4.8e-08
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+GtC +++ +C+C++gy+G +C
  EFC36728.1 714 VCSGRGTCSDFN-KCVCKDGYYGSNC 738
                 7*******9999.************* PP

  == domain 12  score: 22.4 bits;  conditional E-value: 5.3e-08
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C+ghGtC ++   C Cds+y+Gk+C
  EFC36728.1 750 SSNVCSGHGTCSDTD-TCNCDSNYSGKNC 777
                 4789*******7666.8************ PP

  == domain 13  score: 13.1 bits;  conditional E-value: 4.1e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ hG C + + +C C+s+y+  +C
  EFC36728.1 791 LACSSHGFCSSYN-NCTCSSNYYSQQC 816
                 57*******9555.8*********999 PP

  == domain 14  score: 10.3 bits;  conditional E-value: 0.00032
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghGtC +    C+C  ++ G +C
  EFC36728.1 830 SVCSGHGTCSDID-TCSCTGNWIGGNC 855
                 68*******7555.8*********999 PP

  == domain 15  score: 20.3 bits;  conditional E-value: 2.4e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C +++ +C C+ gy+G++C
  EFC36728.1 868 SSVCSGNGVCSSLN-NCTCNVGYYGANC 894
                 578********899.8************ PP

  == domain 16  score: 13.8 bits;  conditional E-value: 2.6e-05
       EGF_2   4 sdeiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                 ++ iC ++G+C   + G+C+C +gy+G  C
  EFC36728.1 906 NEGICANNGSCT--GpGVCSCIDGYSGSRC 933
                 4789********..667************9 PP

  == domain 17  score: 16.2 bits;  conditional E-value: 4.5e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C++ +  C+C++g++ +tC
  EFC36728.1 946 SSVCSGNGQCIDRN-ICSCSAGWTENTC 972
                 578*******9777.9**********99 PP

  == domain 18  score: 17.1 bits;  conditional E-value: 2.4e-06
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C+ +G+Cv +  +C+C+ gy+G++C
  EFC36728.1  984 NSLVCSSQGSCVGPD-NCYCNKGYTGPNC 1011
                  3789********888.8************ PP

  == domain 19  score: 18.7 bits;  conditional E-value: 7.4e-07
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C g+G+C  + G+C C++g+ G  C
  EFC36728.1 1022 NdSSVCLGRGKCL-KPGECTCNTGFRGTEC 1050
                  44789*******8.357************9 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.2   2.5     1e-52   2.3e-49       1     264 []    2086    2345 ..    2086    2345 .. 0.90

  Alignments for each domain:
  == domain 1  score: 168.2 bits;  conditional E-value: 1e-52
                  EEEEEEEEEESSEEEEEEEETTTTEEE.EEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEE.EEEE--TTEBHHHHHHHHSS- CS
     Pkinase    1 yekleklGeGsfGkVykaveketgkiv.AvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely.lvleyveggeladllerkgsl 95  
                  y+++ k+GeG+fG+V+k+++++++++v A+K+i+ ++ ++ +  ++++E + l +++hpni+++ ++f ekd+l+ + +++ ++g+l +l++++   
  EFC36728.1 2086 YKDMVKIGEGAFGSVFKVIDTKNNNKVkAIKVIRYKSVEELN--SMMKEGTQLMNISHPNILKVNDFFVEKDNLLcIDMDFYPQGDLSTLINQQEDC 2180
                  67889**************98877665599999999888866..5*************************99987588******************* PP

                  -HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEE.TTTE...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHH CS
     Pkinase   96 seeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekge...lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvil 187 
                  +e ++k+i++q++++l+++H + ++iHrD+Kp+Ni+i+  +g+     ++DFGlak  ++s   +sf gt+ Y++PE+  + +y +++D +slGv++
  EFC36728.1 2181 KEVHIKQIIYQMCHALHFIHnDLKLIHRDVKPSNIFIKvLNGNvihTVLADFGLAKDNKNSA-SMSFAGTPLYMSPELALGGKYYANTDEYSLGVTV 2276
                  ********************7789**************8788888788***********998.99**************9999************** PP

                  HHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase  188 yelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264 
                  y+l+t+ ++ +   ++  ++k++++      + + t++ l+e  + s+ ++d++ ++l+kd+  R+ a+++l+++y+
  EFC36728.1 2277 YQLITKDTMTA--ISHLYMSKDAKE------VQTLTRKRLKESGDYSDRLIDICLQMLEKDNCARPYAQDILENSYF 2345
                  *********99..222333444444......333356789999999****************************998 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.4   0.5   2.7e-33   6.1e-30       6     257 ..    2091    2341 ..    2087    2342 .. 0.82

  Alignments for each domain:
  == domain 1  score: 104.4 bits;  conditional E-value: 2.7e-33
                   EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSS.EEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr    6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeep.llivteyvkgGdLlkfLrkkekekl 100 
                   k+GeGafG+V++   +   ++++   a+K+++ ++ ee  +++++e + +++++hpni+k+  + +++++ l+i +++ ++GdL++ ++++  e +
   EFC36728.1 2091 KIGEGAFGSVFKVIDT---KNNNKVKAIKVIRYKSVEE-LNSMMKEGTQLMNISHPNILKVNDFFVEKDNlLCIDMDFYPQGDLSTLINQQ--EDC 2180
                   89**********9888...44455559****7776666.9*************************9666637888***********99997..999 PP

                   BHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE..TT..EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHH CS
  Pkinase_Tyr  101 tlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse..nk..vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsf 191 
                   +  ++ ++++q++++++++++  kl+Hrd+   N++++   ++  +  ++DfGLa+d     + +++ +      +m+pE    +k+  ++D +s 
   EFC36728.1 2181 KEVHIKQIIYQMCHALHFIHNDlKLIHRDVKPSNIFIKVlnGNviHTVLADFGLAKDN----KNSASMSFAGTPLYMSPELALGGKYYANTDEYSL 2272
                   999****************97548*************965444124469*******99....3334444555667********************* PP

                   HHHHHHHHTTSSGT.TTTS.HHHH.HHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr  192 GvllwEiftlgesp.ypgl.knee.vleklkegkrlekpekcpeelyelmkkcweedpeeRptfselve 257 
                   Gv+++ ++t+  ++ +++l ++++    +  ++krl++  + +++l ++  + +e+d   Rp  ++++e
   EFC36728.1 2273 GVTVYQLITKDTMTaISHLyMSKDaKEVQTLTRKRLKESGDYSDRLIDICLQMLEKDNCARPYAQDILE 2341
                   *******9965544244443333302333467899***************************9999876 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.0    0.0073        16      12      27 ..     105     120 ..     102     121 .. 0.93
   2 !    7.2   0.0    0.0025       5.5       1      23 [.     150     172 ..     150     177 .. 0.84
   3 !    7.5   0.0     0.002       4.4       3      27 ..     209     233 ..     207     234 .. 0.90
   4 ?   -0.9   0.0      0.92   2.1e+03       3      26 ..     263     286 ..     261     287 .. 0.86
   5 ?    2.5   0.0     0.079   1.8e+02       1      26 [.     302     327 ..     302     327 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0073
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 n+++y+ D++n+rv++
  EFC36728.1 105 NNELYIMDYGNNRVRK 120
                 79************97 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0025
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +n P+G+ + snGdiy++++  +
  EFC36728.1 150 LNGPWGIHIPSNGDIYITEYVGN 172
                 799***************95444 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.002
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                 +P++v v+  G+i++aD+ n r+++
  EFC36728.1 209 SPWSVFVNAIGEIFIADTDNDRIRK 233
                 7999999*************99986 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.92
                 SEEEEEEETTTEEEEEECCCTEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvq 26 
                  P++v +++ +++++a+    r++
  EFC36728.1 263 KPTSVFISPANELFIAEADGGRIR 286
                 68999999********99999987 PP

  == domain 5  score: 2.5 bits;  conditional E-value: 0.079
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +nyP+   v  n d+y+++ +n++++
  EFC36728.1 302 LNYPTFAFVAENSDLYITEKNNNQIR 327
                 56777777778889*********995 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.4   2.4e-07   0.00054      49     117 ..    1985    2052 ..    1945    2067 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 2.4e-07
     TMEM154   49 lsnesdqlelvlmiiiPlvllillllvviiliqkkkrkrsKddekseaesd...eldsenvkvpifEedvps 117 
                  +s  +  l++ l ii+Pl +++++++++ii++    r r+K   +se+++    el +en k  +f+ d+ +
  EFC36728.1 1985 TS--DPALAIALGIILPLLAIAIIIVIIIIVVILVLRYRKKKL-SSEVSNTsaiELRNEN-KRGLFDTDISD 2052
                  33..335788999*****9999998888888877777777766.5555544456777777.77788888765 PP

>> RIFIN  Rifin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   3.2   5.2e-07    0.0012     269     307 ..    1985    2024 ..    1835    2029 .. 0.45

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 5.2e-07
       RIFIN  269 veattaslqtaiiasivai.vvIvLimvIIYLiLRYrRKk 307 
                  ++     +   ii   +ai ++Iv+i++++ L+LRYr+Kk
  EFC36728.1 1985 TSDPALAIALGIILPLLAIaIIIVIIIIVVILVLRYRKKK 2024
                  2222334456688888899344566667788*****9998 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1   4.3e-05     0.096     318     388 ..    2195    2260 ..    2178    2269 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4.3e-05
  Pkinase_fungal  318 ghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkg 388 
                      ++   +++ +++HrD+   Ni i    + +  + +L+D+ lak+ ++  s+  +    GT+ +m+ e+  g
      EFC36728.1 2195 ALHFIHNDLKLIHRDVKPSNIFIK-VLNGNVIHTVLADFGLAKDNKN--SA--SMSFAGTPLYMSPELALG 2260
                      5666788999*************9.545568899*********9995..33..34689******9887665 PP

>> Corona_NSP4_C  Coronavirus nonstructural protein 4 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.2   2.7e+03      67      89 ..    1187    1210 ..    1176    1216 .. 0.77
   2 ?   10.5   0.0   0.00037      0.84      64      95 ..    1952    1983 ..    1888    1984 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.2
                     HHHHHHHHHH.HS---EEE---EE CS
  Corona_NSP4_C   67 hLakaledfs.nsgndvlytPPtv 89  
                       + +l+d+   ++ + ly PP +
     EFC36728.1 1187 SCSTSLNDYLkSQQREYLYIPPSY 1210
                     4567899998356789******86 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00037
                     HHHHHHHHHHHHHHS---EEE---EEEEEXXX CS
  Corona_NSP4_C   64 ayahLakaledfsnsgndvlytPPtvsvtssl 95  
                     +++ L++ l++f + +nd++y PPt s t  +
     EFC36728.1 1952 TISCLTNHLTTFAVFKNDIIYIPPTNSTTNGV 1983
                     56789999*******************99765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2352 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1238  (0.0690501); expected 358.6 (0.02)
Passed bias filter:                      505  (0.0281667); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.31u 0.34s 00:00:01.65 Elapsed: 00:00:00.55
# Mc/sec: 12966.54
//
Query:       EFC36729.1  [L=665]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.6e-18   66.4   7.6    5.3e-18   65.3   7.6    1.6  1  Ferric_reduct  Ferric reductase like transmembrane component
    6.4e-18   65.2   1.0    1.4e-16   60.8   0.4    2.7  2  DOMON          DOMON domain
    9.8e-10   38.8   1.2    3.2e-09   37.1   0.1    2.5  3  NAD_binding_6  Ferric reductase NAD binding domain
    1.1e-05   25.5   0.1    2.7e-05   24.2   0.1    1.6  1  FAD_binding_8  FAD-binding domain
    0.00033   21.3   0.1     0.0017   19.0   0.1    2.3  2  NAD_binding_1  Oxidoreductase NAD-binding domain


Domain annotation for each model (and alignments):
>> Ferric_reduct  Ferric reductase like transmembrane component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.3   7.6   1.5e-21   5.3e-18       2     121 ..     236     350 ..     235     354 .. 0.93

  Alignments for each domain:
  == domain 1  score: 65.3 bits;  conditional E-value: 1.5e-21
  Ferric_reduct   2 Giaalillplallla..lRnnflepltglsldklllfHkwlgvlafllallHvilyllnflrfsaldeerlldsllkkpynllGvlalllliilai 95 
                    G +++i l+ ++l+   +R n+l+ l+g+s+++ l fHkwlg ++f +a+ H++  ++ f        +  +    ++ + l+G++a+l l++l++
     EFC36729.1 236 GYVQMIILNYIFLFIpvTRYNVLQALFGISFERSLKFHKWLGFMIFGFATGHGVTEFVSFRD------NIPYMFSAEDQFPLFGIIAWLSLGLLLL 325
                    889999999999966579******************************************97......8999999********************* PP

  Ferric_reduct  96 tSlkfirrrlsyelFyylHhllyvay 121
                    +S+++ir r  yelF++ H+ l ++ 
     EFC36729.1 326 FSFNPIR-RKLYELFLVFHIPLTLVT 350
                    *******.7779*******9888776 PP

>> DOMON  DOMON domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.8   0.4     4e-20   1.4e-16      13     125 .]      14     126 ..       1     126 [. 0.92
   2 ?    1.9   0.0     0.069   2.5e+02      80     103 ..     392     415 ..     390     426 .. 0.84

  Alignments for each domain:
  == domain 1  score: 60.8 bits;  conditional E-value: 4e-20
       DOMON  13 gdgdeiefelsgkvntngyvaiGfsd..dgkMsnadvvvgwvdngrvyvqdyystggkgapriddt..gsqditllsgseengvttlkfrRkldtcdpk 107
                 ++++ +ef l + vn  gy+aiGf +  d++M+  d +++++ +g++y++d y+++++  p+id+   g++d+   +g + +g  + + +Rk++t+d+ 
  EFC36729.1  14 STNHILEFGLIC-VN-AGYCAIGFDHplDKGMNSIDTMFAYTISGTAYLKDAYCKTKHVFPTIDELsgGTNDYLETNGGVIDGQYHYRWSRKVNTGDS- 109
                 567778899995.88.9***********************************************7799*****************************9. PP

       DOMON 108 qdnkidldttvyviwaag 125
                 qd ++ ++++vyv wa++
  EFC36729.1 110 QDATF-KNSNVYVSWAYH 126
                 *****.**********86 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.069
       DOMON  80 ditllsgseengvttlkfrRkldt 103
                  +t++s++e ++vtt+ f++++ t
  EFC36729.1 392 KLTQISYDEDSEVTTCVFEKRFLT 415
                 57899**************99876 PP

>> NAD_binding_6  Ferric reductase NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.96   3.5e+03       6      19 ..     282     295 ..     279     304 .. 0.81
   2 ?   -3.0   0.0         2   7.1e+03      30      64 ..     447     480 ..     437     486 .. 0.71
   3 !   37.1   0.1   8.9e-13   3.2e-09       3     155 ..     511     646 ..     509     647 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.96
                    xxxxxxxxxxxxxx RF
  NAD_binding_6   6 lvagGiGitpfisi 19 
                      a G G+t f+s+
     EFC36729.1 282 GFATGHGVTEFVSF 295
                    5799********97 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6  30 ealktkkikliwvvressslewfkdvLneleeeks 64 
                     +l++ ++++i+ ++  +   w    L +l++ k+
     EFC36729.1 447 VKLENGNHQFICHIKRMEGGTWAA-KLAQLAKSKK 480
                    467778899999999998888888.5555655554 PP

  == domain 3  score: 37.1 bits;  conditional E-value: 8.9e-13
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6   3 nvllvagGiGitpfisilkdllkkskkealktkkikliwvvressslewfkdvLneleeeksegnieihiYlTseyeaedasdqlissiegenses 98 
                    +++++ +GiG+tp+  il  l      +     k++  + +r++  l  ++++++    +k++  +e + Y+T+++++++  + +++    ++ + 
     EFC36729.1 511 TIVFIVAGIGATPCNAILTALEDPKY-NDPTPYKVYVNFTMRNEATLAQMSKIMQ----QKPN--VECSFYVTGVKSVKKSIELMEKG---QDNS- 595
                    789*************9998876665.7778889999999999999988885555....6665..*********99887765544444...3222. PP

                    xxxxxxxxxxxxxxxxxxx.xxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6  99 lkqgvdavsgtrnvkihfg.RPnlkevlkdi....askhknssvgvfvCGppklvkevkklv 155
                      +          +++  g RPn  e+l++i     + +  + v vf CGp k+++ v ++v
     EFC36729.1 596 --ED---------KRFVRGsRPNYVEYLEKIksqiIQSKSLEYVSVFACGPSKMMNAVHNAV 646
                    ..22.........4677778***********766656666778**************99976 PP

>> FAD_binding_8  FAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   0.1   7.7e-09   2.7e-05      33     107 ..     423     496 ..     394     499 .. 0.78

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 7.7e-09
  FAD_binding_8  33 GqyvyinipslsklfwqsHPFtiasape....ddklslvikvksg..ltkklakkllssskkelenkkaklkvlidGPYGa 107
                      yv+++ip++s   +q HP ti s+ +    + +   +ik  +g  +  kla+   s+     +   +   v ++G YG+
     EFC36729.1 423 AHYVFVYIPQVS--IYQLHPMTISSSVKlengNHQFICHIKRMEGgtWAAKLAQLAKSK-----KMVSEYYGVRVEGAYGN 496
                    68**********..78*********9999998899999999876512666666666665.....23455567888888886 PP

>> NAD_binding_1  Oxidoreductase NAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0         5   1.8e+04       3      15 ..     284     296 ..     284     299 .. 0.84
   2 !   19.0   0.1   4.6e-07    0.0017       1     108 [.     514     643 ..     514     644 .. 0.72

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 5
                    EEGGGGHHHHHHH CS
  NAD_binding_1   3 agGtGiaPvrsvl 15 
                    a+G G++ ++s+ 
     EFC36729.1 284 ATGHGVTEFVSFR 296
                    89*****999985 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 4.6e-07
                    EEEEGGGGHHHHHHHHHHHHHCT....TCSEEEEEEEESSGCGSTTHHHHHHHHHHCTT.EEEEEEE...........ESSCTTTSSSEESSHHH. CS
  NAD_binding_1   1 miagGtGiaPvrsvlraileeak....dktkvvlvyGnrteedllyreeleelakklpg.rlkvvav...........vsreeagweggkgrvqd. 79 
                    +i +G G +P+ ++l a+ +  k     + kv++ + +r+e+ l+   ++ ++ +++p+ ++ ++ +             ++ +++++ k +v   
     EFC36729.1 514 FIVAGIGATPCNAILTALEDP-KyndpTPYKVYVNFTMRNEATLA---QMSKIMQQKPNvECSFYVTgvksvkksielM-EKGQDNSEDKRFVRGs 604
                    6899***********999886.55666667889999999999995...8888889999986666555669999888852.3333333444455431 PP

                    ..HHHHHHHH........HSSTTEEEEEECSHHHHHHHH CS
  NAD_binding_1  80 ..alleells........lkkeethvyvCGppgMikavr 108
                      +++e+l++         ++e + v+ CGp +M++av+
     EFC36729.1 605 rpNYVEYLEKiksqiiqsKSLEYVSVFACGPSKMMNAVH 643
                    11233333336668887988999*************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       770  (0.0429472); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.37s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 3718.82
//
Query:       EFC36730.1  [L=1139]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-82  277.0  26.8    1.7e-82  277.0  26.8    2.8  3  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t
      3e-26   90.9   8.5      3e-26   90.9   8.5    2.1  2  PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
    1.2e-12   47.7   0.0    5.8e-12   45.5   0.0    2.1  2  Cation_ATPase    Cation transport ATPase (P-type)
    3.7e-10   40.5   0.0    6.7e-07   29.8   0.0    2.9  2  Hydrolase        haloacid dehalogenase-like hydrolase
    1.4e-08   34.5   0.0    4.4e-08   32.9   0.0    1.9  1  E1-E2_ATPase     E1-E2 ATPase
  ------ inclusion threshold ------
      0.026   14.3   0.2      0.026   14.3   0.2    2.7  4  Hydrolase_3      haloacid dehalogenase-like hydrolase


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   1.0      0.14   4.3e+02     190     238 ..      86     130 ..      53     140 .. 0.51
   2 ?   -3.2   1.9       1.9   5.6e+03     189     227 ..     327     367 ..     267     398 .. 0.49
   3 !  277.0  26.8   5.6e-86   1.7e-82       1     246 [.     860    1099 ..     860    1102 .. 0.98

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.14
  PhoLip_ATPase_C 190 lyflflllyssllpsssefygvleelfss.psfwlvlllvvvvallpdll 238
                      +yflf+++++++++        + ++ +s p ++ ++++ ++v+++ d +
       EFC36730.1  86 CYFLFMAILQTIPTL-----SPTGQFTNSvPLCFGMFVIFLFVTMIKDAF 130
                      677777777776653.....222334444233333344444444444444 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.9
  PhoLip_ATPase_C 189 llyflflllyssllps.ssefygvleelfss.psfwlvlll 227
                      + y++++++ +  +   s + +++++ +++    fw+ lll
       EFC36730.1 327 GGYIAWTYFNTDAWYIfSDQKVNMDYLAWNGfKGFWTFLLL 367
                      25555554444443334333333333333332334444333 PP

  == domain 3  score: 277.0 bits;  conditional E-value: 5.6e-86
  PhoLip_ATPase_C    1 vraSDyaiaqFrfLkrLLlvhGrwsyrRisklilyffyKnvvftlvqfwfqfyngfsgqslyeswlltlynllftslpvivlgifdqdvsae 92  
                       v+aSDyai+qFrfLkrLLlvhGrw+yrR+skl++y+fyKn++f+l+q+wf++yng+sg sl+++w+++lyn++ft lp+++l+ +d+dv++ 
       EFC36730.1  860 VNASDYAIGQFRFLKRLLLVHGRWNYRRVSKLVVYVFYKNILFFLTQLWFNIYNGYSGASLHDNWTIALYNTIFTGLPIVALAFMDRDVPDY 951 
                       79****************************************************************************************** PP

  PhoLip_ATPase_C   93 lllkyPelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvaletktwtliliili 184 
                       +++kyPelY +gqkn++fn k f+ wi++++++s+i+ff++y++l ds+f dg++ d q++g++v+++++ v+++k+a+et +wt+++++++
       EFC36730.1  952 IAEKYPELYFQGQKNRYFNAKIFISWIVNAVFHSTICFFIPYYCLVDSKFIDGQDIDTQTIGIAVYSCVLAVTLFKLAIETASWTIVHCLFY 1043
                       *********************************************999999***************************************** PP

  PhoLip_ATPase_C  185 lgsillyflflllyssllpsssefygvleelfsspsfwlvlllvvvvallpdllikvlkrtf 246 
                       +g  l++ +f++ y s++      y +  ++f sp+f+++l+lv ++++l+d+++k + r++
       EFC36730.1 1044 FGFYLSFPAFVFSYGSVY------YLIKWRIFLSPQFYFILMLVAFACCLRDIFWKGFVRMY 1099
                       **999*********9964......56799****************************99987 PP

>> PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.9   8.5     1e-29     3e-26       1      66 [.      43     108 ..      43     109 .. 0.97
   2 ?   -3.3   0.1       2.6   7.7e+03      43      56 ..     503     516 ..     500     518 .. 0.63

  Alignments for each domain:
  == domain 1  score: 90.9 bits;  conditional E-value: 1e-29
  PhoLip_ATPase_N   1 vyindreenekkkyasNkIsTsKYtlltFlpknLfeqFrrvaNlYFLviailqliPqisplspvtt 66 
                      vy+nd+++n+k ky++N+I+T+KYt l+Fl+knL+eqF+r+aN+YFL++ailq+iP++sp++++t 
       EFC36730.1  43 VYANDEKSNSKYKYVKNQITTTKYTYLNFLFKNLIEQFQRFANCYFLFMAILQTIPTLSPTGQFTN 108
                      79*****9*999***************************************************995 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.6
  PhoLip_ATPase_N  43 NlYFLviailqliP 56 
                      N++  + ++ ++iP
       EFC36730.1 503 NFFIVLAICNTVIP 516
                      66666666666677 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.5   0.0   1.9e-15   5.8e-12       2      85 ..     510     604 ..     509     609 .. 0.91
   2 ?   -2.4   0.0       1.7   5.1e+03      15      28 ..     707     720 ..     701     733 .. 0.86

  Alignments for each domain:
  == domain 1  score: 45.5 bits;  conditional E-value: 1.9e-15
  Cation_ATPase   2 lcNsaafsensekdevkllGnktEsALlvlaekl............gldteelreetkkvqeipFnssrKrmsvvlklepekkvrlyvKGApeiil 85 
                    +cN    +en+++d v  + +++E+AL+++a+ l            ++ + +  +e++ v++i+F+s+rKr+sv++k  pe+++++++KGA  ++ 
     EFC36730.1 510 ICNTVIPEENDDNDIVYQSSSPDEAALVKAAKYLgvelvnkamntiTIRVLKEIREYTLVEVIEFSSDRKRQSVIVKD-PEGRLLIMTKGADSVVS 604
                    7999999***************************9999999888776666667778*********************8.9***********98875 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.7
  Cation_ATPase  15 devkllGnktEsAL 28 
                    + + l+G+k E+A+
     EFC36730.1 707 NIWMLTGDKLETAI 720
                    56889********8 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.8   0.0   2.3e-10   6.7e-07       1     150 [.     420     721 ..     420     740 .. 0.86
   2 !    7.0   0.0    0.0022       6.6     172     210 .]     807     846 ..     782     846 .. 0.78

  Alignments for each domain:
  == domain 1  score: 29.8 bits;  conditional E-value: 2.3e-10
                 SSEEEEESBTTTBCHHHHHHHHHHHHCHHHHHHHHHH.........HHCHHHHHHHHHHHHH..HHHHHHHHHETTTE.....HHHHTHHHHHHHH... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxx..xxxxxxxxxxxxxx.....xxxxxxxxxxxxx... RF
   Hydrolase   1 iktvvfDkdGTLttgepsvedvivsaalalaaaletg.........sehpigkalvaaakar..sgaltgfatfigrg.....ayaigkpewltal... 80 
                 i+ ++ Dk+GTLt+ ++  +++ vs        + +g         + + +g+ +v +  a+      ++f+ + +r      + ++++ ++l+     
  EFC36730.1 420 INYIFSDKTGTLTENKMDFMKFSVSG-------IMYGtgiteisriTARKHGQEVVDERPAHvrN---SDFHFYDERIndgawVKQENSADLLNFFivl 508
                 7889*****************99999.......22222255554777777777777666666331...3444444444545666666666666666777 PP

                 .....HCHHHHHHHHHHHHHHCHHHHHH....................................................................... CS
                 .....xxxxxxxxxxxxxxxxxxxxxxx....................................................................... RF
   Hydrolase  81 .....dippdlgaaigsaqsqgrtvall....................................................................... 103
                       ip++ ++++  +qs   ++a l                                                                       
  EFC36730.1 509 aicntVIPEENDDNDIVYQSSSPDEAALvkaakylgvelvnkamntitirvlkeireytlveviefssdrkrqsvivkdpegrllimtkgadsvvsrll 607
                 778888888888888888888888888889999999999999999999999999999999*************************************** PP

                 .....................................................................TTHHHHHHHHHHTHHBHTTHHHHHHHHHHT CS
                 .....................................................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 104 .....................................................................qaralavftiadplkvkpeaaeavasLkaa 133
                                                                                      +   ++  +i+d+  + +++ e+++ L++a
  EFC36730.1 608 cnesreqygkvtiqhldhfgneglrtmicaqsfldeeafkiwreeyemakisienrqetielvgakietNLSFVGATAIEDK--LQQGVGETIYDLRKA 704
                 *******************************************************************999999999999999..*************** PP

                 TEEEEEEESSEHHHHHH CS
                 xxxxxxxxxxxxxxxxx RF
   Hydrolase 134 gievvlltgdnpetaer 150
                 gi++++ltgd  eta  
  EFC36730.1 705 GINIWMLTGDKLETAIN 721
                 ************99965 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0022
                 TTTSHHHHHHHHHHHTST.GGGEEEEESSHHHHHHHHHTT CS
                 xxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 172 akpspegkvaaireLqgk.peevamVGDgvnDaaalaaAg 210
                   +sp++k  ++  ++ +    ++++GDg nD+++++ A+
  EFC36730.1 807 CRVSPKQKSDIVLLIKNNvTCVTLAIGDGSNDVSMIQSAN 846
                 567888888888888755566799************9986 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.9   0.0   1.5e-11   4.4e-08       4     167 ..     144     380 ..     142     393 .. 0.76

  Alignments for each domain:
  == domain 1  score: 32.9 bits;  conditional E-value: 1.5e-11
                   --EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.....EEE-TTTS---S-EE-............................... CS
  E1-E2_ATPase   4 pptakvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa.....evdesaLTGEslpvek............................... 64 
                    ++a+v+r+++ +++  k++++GDi+ +++++  p+D +++++s+      v++s L GEs    k                               
    EFC36730.1 144 NQRAHVLRGDEFVDVLWKDIKTGDILRVENNEAFPCDLILLSSSHnqglcYVETSGLDGESNLKIKkcrsetislksaeilndsrmivecekpnnrl 240
                   6789**************************************766656679**********999998************************999999 PP

                   ..................G-TTEE-TT-EEEE-E.EEEEEEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHH...HHS-ST CS
  E1-E2_ATPase  65 ..................ekgdmvfsGtvvvsge.akavVtatgedtelgkiarlveeakskktplqkkldklgkvlvpvvlliallv...fliall 139
                                     ++++ +  G++ ++ e ++++ + tg+dt+l   +  ++++ +k ++++++++kl+  ++++ +++al +   ++++ +
    EFC36730.1 241 ykfegtlmlnsekkqialDTEQICLRGSSLKNTEfMIGISIFTGSDTKL---MMNTKATPHKISKIERMINKLILLVFAFEIMLALGLdggYIAWTY 334
                   9999999999999988888999999999999865256777888888855...555666668899999999999888777666666654333344444 PP

                   TTSSTT..................HHHHHHHHHHHHHS-TTHHHHH CS
  E1-E2_ATPase 140 lgksla..................eallralallvaaiPcaLplav 167
                    + +++                  + +  +l ll+  iP+ L + +
    EFC36730.1 335 FNTDAWyifsdqkvnmdylawngfKGFWTFLLLLTDLIPISLYVSI 380
                   4444435566666666666665555556666666666666665555 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.4       1.1   3.3e+03     121     165 ..      36      80 ..      20      94 .. 0.51
   2 ?   -3.5   0.0       2.3   6.8e+03     124     177 ..     386     437 ..     333     457 .. 0.66
   3 ?   -3.3   0.0       2.1   6.2e+03      16      48 ..     690     722 ..     687     735 .. 0.81
   4 ?   14.3   0.2   8.6e-06     0.026     206     227 ..     829     850 ..     825     856 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.1
                  HHCHCTCEEEESHHHHHCHCSESEEEEES-HHHHHHHHHHHHHHC CS
  Hydrolase_3 121 eektkkkkeeidseeeledeeiakililkdkekldelekelkskl 165
                  ++++++ ++ +d++++ + + + + ++ ++ + l+ l+k+l +++
   EFC36730.1  36 KDSNTRIVYANDEKSNSKYKYVKNQITTTKYTYLNFLFKNLIEQF 80 
                  333333333333333333334444445555555555555555555 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.3
                  HCTCEEEESHHHHHCHCSESEEE.EES-HHHHHHHHHHHHHHCTTTEEEEEESTT CS
  Hydrolase_3 124 tkkkkeeidseeeledeeiakil.ilkdkekldelekelksklnklltitssskg 177
                  +++ + ++d ++++e+++   i+  ++ +e+l +++  +++k++   t t+++  
   EFC36730.1 386 FQTMMISKDLKMYNETTDTPTIVrSSALHEDLGQINYIFSDKTG---TLTENKMD 437
                  44455555566666666666666666667777777777766665...34444444 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 2.1
                  --HHHHHHHHHHHHTTSEEEEE-SS-HHHHHHH CS
  Hydrolase_3  16 isektkeaikklkekgikvviATGRslravlpv 48 
                  +++   e+i  l+++gi++   TG +l++++++
   EFC36730.1 690 LQQGVGETIYDLRKAGINIWMLTGDKLETAINI 722
                  666777899999999999999999888888776 PP

  == domain 4  score: 14.3 bits;  conditional E-value: 8.6e-06
                  EEEEESSGGGHHHHHHSSEEEE CS
  Hydrolase_3 206 viafGDgeNDieMLeaaglgvA 227
                  ++a+GDg ND++M++ a++g+ 
   EFC36730.1 829 TLAIGDGSNDVSMIQSANVGIG 850
                  79***************99985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1139 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       743  (0.0414412); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.82u 0.35s 00:00:01.17 Elapsed: 00:00:00.53
# Mc/sec: 6505.45
//
Query:       EFC36731.1  [L=1237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-42  145.4   3.6    1.1e-41  142.9   2.9    2.7  2  Pkinase          Protein kinase domain
    5.4e-31  106.4   4.3    1.3e-06   28.3   0.0    6.2  6  Kelch_4          Galactose oxidase, central domain
    5.5e-29  101.2   1.9    6.1e-27   94.5   1.9    2.8  2  Pkinase_Tyr      Protein tyrosine kinase
    1.3e-26   92.0   0.9    8.4e-05   22.5   0.0    7.4  7  Kelch_5          Kelch motif
      2e-20   72.3   2.8    8.9e-05   22.6   0.0    6.2  6  Kelch_6          Kelch motif
    6.3e-17   60.8   7.2    3.8e-05   23.5   0.1    6.2  6  Kelch_2          Kelch motif
    1.8e-16   59.9   5.2      0.017   15.4   0.0    8.6  8  Kelch_3          Galactose oxidase, central domain
    2.4e-11   43.0   0.2      0.011   15.3   0.0    5.1  5  Kelch_1          Kelch motif
  ------ inclusion threshold ------
       0.12   12.3   0.5        0.4   10.6   0.5    1.8  1  Phe_tRNA-synt_N  Aminoacyl tRNA synthetase class II, N-termin
       0.13   11.6   0.0       0.33   10.3   0.0    1.6  2  Kdo              Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.42   7.6e+02       1      26 [.     668     691 ..     668     714 .. 0.75
   2 !  142.9   2.9   6.3e-45   1.1e-41      22     260 ..     714    1002 ..     704    1004 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.42
                 EEEEEEEEEESSEEEEEEEETTTTEE CS
     Pkinase   1 yekleklGeGsfGkVykaveketgki 26 
                 y+ ++ lG+G+ ++V+ ++++  +  
  EFC36731.1 668 YVIERLLGRGGQACVFLVRDE--NAS 691
                 677899***********9954..444 PP

  == domain 2  score: 142.9 bits;  conditional E-value: 6.3e-45
                  TTTEEEEEEEEECHCHCHHHH......HHHHHHHHHHHHHSCTTB--EEEEEEE...........................SSEEEEEEE--TTEBH CS
     Pkinase   22 etgkivAvKkikkekakkkke......kkvlrEikilkklkhpnivrlyevfee...........................kdelylvleyveggel 85  
                  +t+k +A+K+++   +++  +      ++v++Ei il++lkh ni+  +++f e                           +  l +++ y+e g+l
  EFC36731.1  714 STSKYYALKRMDIIFNDNVGRnksvasDSVFNEILILQQLKHVNILPTLSFFIEkrmmminqekqhdnntnsggdnnnemvSLVLNIIMPYCESGDL 810 
                  6888899998764333332222336669************************999*********************8877666777**********9 PP

                  HHHHH.......HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE................EEE-SGTTSEESSSSCSBCTTT CS
     Pkinase   86 adlle.......rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge................lKitDFGlakelessskltsfv 158 
                    ++        + g+ +e e+ +++ qi+ +ley+H+++iiHrDlKp+Ni++  e+ +                +K++DFGlak+++ss  +++ +
  EFC36731.1  811 SMFYVrkvnywnKIGNWNELEIIEWLIQIALALEYIHERNIIHRDLKPSNIFVTfENSNntnnnntnysndmkpiMKLSDFGLAKNVQSSL-ARTAC 906 
                  88888455566555556777**********************************873334555666777778899**************98.***** PP

                  SCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS..-HHHHHHHHHHT-SSGCCST CS
     Pkinase  159 gtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasei..seeakdllkkllkkdpkkRl 253 
                  gt  YlAPE+ +e +ys+kvD+Ws G+i++ +l+  ++        +++  +++ +ki + l++ +ek+ + +++  ++e +++l ++++ +p+kR+
  EFC36731.1  907 GTMLYLAPEIYNEDSYSEKVDIWSFGCIVAFMLYSGQLKI------DFKIPTNK-KKISDYLKP-NEKVTNVQKLigKDEYLQILFDCVEIEPEKRP 995 
                  ******************************9987666554......23333333.445566766.45555555555899****************** PP

                  THHHHHT CS
     Pkinase  254 taeellq 260 
                  +a+++++
  EFC36731.1  996 SASQIVN 1002
                  ****997 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.82   1.5e+03       8      38 ..     120     152 ..     117     152 .. 0.66
   2 !   28.3   0.0   7.2e-10   1.3e-06       1      43 [.     290     333 ..     290     345 .. 0.89
   3 !   22.4   0.1   5.2e-08   9.4e-05       1      36 [.     407     440 ..     407     453 .. 0.94
   4 !   23.8   0.0   1.9e-08   3.4e-05       1      44 [.     480     522 ..     480     529 .. 0.91
   5 !   16.3   0.1   4.1e-06    0.0074       2      43 ..     536     575 ..     535     584 .. 0.93
   6 !   10.9   0.0    0.0002      0.36       1      39 [.     605     649 ..     605     658 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.82
     Kelch_4   8 tsipdg.tiylfGGrgedg.tllndlylldlst 38 
                   i+d+ +i+ f G  + g ++ n+++l++ +t
  EFC36731.1 120 NNIDDNeSIIAFMGGISIGfKRINNVWLFSPKT 152
                 44544335666655556688999*****99876 PP

  == domain 2  score: 28.3 bits;  conditional E-value: 7.2e-10
     Kelch_4   1 pRaghsatsipd.gtiylfGGrgedgtllndlylldlstntWrr 43 
                 pR  h+++ ip    i +fGG+ ++  +lnd+++l+l+t tW +
  EFC36731.1 290 PRERHGMCTIPEsKFILIFGGIADKKIRLNDVWFLNLETMTWHE 333
                 66789999997769****************************76 PP

  == domain 3  score: 22.4 bits;  conditional E-value: 5.2e-08
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtllndlylldl 36 
                 +R +hs+t i +++i l+GG+ +  ++ nd++ll++
  EFC36731.1 407 ARYYHSLTPISNNSILLYGGYDG--SFRNDMWLLNI 440
                 7**********************..6*********8 PP

  == domain 4  score: 23.8 bits;  conditional E-value: 1.9e-08
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtllndlylldlstntWrrl 44 
                 pR +h +  + +++i lfGG  e+g   ndl+l+d+ + +W+ l
  EFC36731.1 480 PRYNHWCGLV-KDKILLFGGVLEKGIQTNDLWLFDIDSYRWKNL 522
                 89********.79*************************999755 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 4.1e-06
     Kelch_4   2 RaghsatsipdgtiylfGGrgedgtllndlylldlstntWrr 43 
                 R +h +++++   ++l+GG + +   ln++++ldl+t +W++
  EFC36731.1 536 RSDHKCVVLG-KFLILVGGVYKK-LYLNNTFVLDLETLQWKK 575
                 889999***6.8***********.7***************86 PP

  == domain 6  score: 10.9 bits;  conditional E-value: 0.0002
     Kelch_4   1 pRaghsatsi.pdgtiylfGGrgedg...tllndlyll..dlstn 39 
                 +R+g+ +  i ++g+  +fGG+ +++   ++ nd++ll  +l  n
  EFC36731.1 605 ARIGFIIQPIsNSGKALIFGGIVDKDklvARANDMWLLetNLNEN 649
                 67888888884559************9999999999975565555 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.8   3.2e+03     211     245 ..     169     203 ..     162     206 .. 0.85
   2 !   94.5   1.9   3.4e-30   6.1e-27      75     259 .]     794    1004 ..     713    1004 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.8
                  HHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SS CS
  Pkinase_Tyr 211 neevleklkegkrlekpekcpeelyelmkkcweed 245
                   ++v++++k+++r ++ ++ ++ l++lm++ +++d
   EFC36731.1 169 FTNVANFIKSNNRKDELTYLHTYLNNLMNQILRQD 203
                  56789999********************9988766 PP

  == domain 2  score: 94.5 bits;  conditional E-value: 3.4e-30
                   S...EEEEEE--TTEBHHHHHHHT.....CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.................TTEEEE- CS
  Pkinase_Tyr   75 p...llivteyvkgGdLlkfLrkk.....ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.................nkvvkis 145 
                       l i++ y+++GdL+ f  +k     +  + +  +++++ +q+A ++ey+++++++Hrdl   N++++                  + ++k+s
   EFC36731.1  794 VslvLNIIMPYCESGDLSMFYVRKvnywnKIGNWNELEIIEWLIQIALALEYIHERNIIHRDLKPSNIFVTFensnntnnnntnysndmKPIMKLS 889 
                   144477999********999888889987778899999********************************9888999**********9999***** PP

                   STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTS...HHHHHHHHHHTTEES-BBTTS..BHHHHH CS
  Pkinase_Tyr  146 DfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypgl...kneevleklkegkrlekpekc..peelye 236 
                   DfGLa+++    + + +++a   + ++apE+ +e ++++k D+WsfG ++  ++  g+  +      +++++ ++lk ++++++ +k   ++e  +
   EFC36731.1  890 DFGLAKNV----QSSLARTACGTMLYLAPEIYNEDSYSEKVDIWSFGCIVAFMLYSGQLKIDFKiptNKKKISDYLKPNEKVTNVQKLigKDEYLQ 981 
                   ********....4444555667788**********************999999999997754322336677888999888887777653379999* PP

                   HHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  237 lmkkcweedpeeRptfselvekl 259 
                   ++ +c e +pe+Rp+ s++v+kl
   EFC36731.1  982 ILFDCVEIEPEKRPSASQIVNKL 1004
                   *******************9987 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.0    0.0078        14       1      41 [.     100     152 ..     100     153 .. 0.67
   2 !   20.1   0.0   2.6e-07   0.00046       1      41 [.     287     328 ..     287     329 .. 0.87
   3 !   21.2   0.1   1.2e-07   0.00021       1      38 [.     404     439 ..     404     442 .. 0.93
   4 !   22.5   0.0   4.7e-08   8.4e-05       1      41 [.     477     516 ..     477     517 .. 0.95
   5 !    9.8   0.0   0.00043      0.76       1      41 [.     532     570 ..     532     571 .. 0.92
   6 ?    3.1   0.0     0.055        98      14      37 ..     617     642 ..     606     649 .. 0.79
   7 ?   -1.4   0.0       1.4   2.5e+03      26      37 ..     739     750 ..     733     751 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0078
     Kelch_5   1 iPppRaghcavtv.....s.......ekiYvyGGkvgrdgsvs...ddvyvLdlps 41 
                 iPpp++gh+++++     s       e+i+ + G +   ++++   ++v+ +++++
  EFC36731.1 100 IPPPLSGHASCVLdclisSsnniddnESIIAFMGGI---SIGFkriNNVWLFSPKT 152
                 7**********9845555144455456688854444...36666668888888776 PP

  == domain 2  score: 20.1 bits;  conditional E-value: 2.6e-07
     Kelch_5   1 iPppRaghcavtv..sekiYvyGGkvgrdgsv.sddvyvLdlps 41 
                 +P pR +h ++t   s  i+++GG+   d+++  +dv+ L+l++
  EFC36731.1 287 FPIPRERHGMCTIpeSKFILIFGGIA--DKKIrLNDVWFLNLET 328
                 5999*******9954577********..777779*******987 PP

  == domain 3  score: 21.2 bits;  conditional E-value: 1.2e-07
     Kelch_5   1 iPppRaghcav.tvsekiYvyGGkvgrdgsvsddvyvLd 38 
                 iP++R++h+   + +++i++yGG++   gs+ +d++ L+
  EFC36731.1 404 IPTARYYHSLTpISNNSILLYGGYD---GSFRNDMWLLN 439
                 7**********8899**********...8999****997 PP

  == domain 4  score: 22.5 bits;  conditional E-value: 4.7e-08
     Kelch_5   1 iPppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdlps 41 
                 iP pR++h    v++ki+++GG+  + g+ ++d++ +d+ s
  EFC36731.1 477 IPLPRYNHWCGLVKDKILLFGGVL-EKGIQTNDLWLFDIDS 516
                 7***********************.89999********987 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.00043
     Kelch_5   1 iPppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdlps 41 
                 +P+ R++h  v+++  +++ GG+    + + ++ +vLdl++
  EFC36731.1 532 YPERRSDHKCVVLGKFLILVGGVY--KKLYLNNTFVLDLET 570
                 6999********************..67777*******987 PP

  == domain 6  score: 3.1 bits;  conditional E-value: 0.055
     Kelch_5  14 sekiYvyGGkvgrdgsvs...ddvyvL 37 
                 s+k +++GG+v   +++    +d++ L
  EFC36731.1 617 SGKALIFGGIV-DKDKLVaraNDMWLL 642
                 6999*******.577774455888887 PP

  == domain 7  score: -1.4 bits;  conditional E-value: 1.4
     Kelch_5  26 rdgsvsddvyvL 37 
                  ++sv++++++L
  EFC36731.1 739 ASDSVFNEILIL 750
                 5799******99 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0      0.01        18      12      37 ..     126     152 ..     117     159 .. 0.85
   2 !   22.6   0.0     5e-08   8.9e-05       2      42 ..     291     333 ..     290     334 .. 0.87
   3 !   11.7   0.1   0.00014      0.25       1      36 [.     407     441 ..     407     454 .. 0.85
   4 !   13.8   0.0     3e-05     0.053       8      42 ..     487     521 ..     480     530 .. 0.85
   5 !   12.0   0.0   0.00011       0.2       2      42 ..     536     575 ..     535     578 .. 0.94
   6 ?   -1.1   0.0       1.5   2.8e+03      12      24 ..     618     633 ..     614     644 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.01
     Kelch_6  12 gkiYif.GGytdsspylnkvwvydpet 37 
                 ++i +f GG + ++++ n vw+++p+t
  EFC36731.1 126 ESIIAFmGGISIGFKRINNVWLFSPKT 152
                 5777777999999*************9 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 5e-08
     Kelch_6   2 raghslvsvgg..kiYifGGytdsspylnkvwvydpetksWeq 42 
                 r  h ++++ +  +i ifGG  d   +ln+vw++++et++W +
  EFC36731.1 291 RERHGMCTIPEskFILIFGGIADKKIRLNDVWFLNLETMTWHE 333
                 55789989665469*******999*****************86 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 0.00014
     Kelch_6   1 praghsl.vsvggkiYifGGytdsspylnkvwvydpe 36 
                 +r++hsl  + +++i ++GGy++  ++ n++w++++ 
  EFC36731.1 407 ARYYHSLtPISNNSILLYGGYDG--SFRNDMWLLNIL 441
                 589****555788********98..688999*99986 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 3e-05
     Kelch_6   8 vsvggkiYifGGytdsspylnkvwvydpetksWeq 42 
                  +v +ki +fGG    +  +n++w++d+++ +W+ 
  EFC36731.1 487 GLVKDKILLFGGVLEKGIQTNDLWLFDIDSYRWKN 521
                 56889********999*****************85 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 0.00011
     Kelch_6   2 raghslvsvggkiYifGGytdsspylnkvwvydpetksWeq 42 
                 r  h +v+ g ++ ++GG +    yln  +v+d+et  W++
  EFC36731.1 536 RSDHKCVVLGKFLILVGGVYK-KLYLNNTFVLDLETLQWKK 575
                 789******************.9****************85 PP

  == domain 6  score: -1.1 bits;  conditional E-value: 1.5
     Kelch_6  12 gkiYifGGytds...s 24 
                 gk  ifGG +d     
  EFC36731.1 618 GKALIFGGIVDKdklV 633
                 7899****99965554 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.3   2.3e+03       1      20 [.     103     135 ..     103     155 .. 0.62
   2 !   16.0   0.0     5e-06    0.0089      14      49 .]     305     338 ..     293     338 .. 0.86
   3 !    8.4   0.0    0.0012       2.1       1      37 [.     407     440 ..     407     449 .. 0.77
   4 !   23.5   0.1   2.1e-08   3.8e-05       1      45 [.     480     522 ..     480     524 .. 0.97
   5 !   10.7   0.0   0.00022       0.4       1      44 [.     535     575 ..     535     578 .. 0.95
   6 ?   -1.0   0.0       1.1     2e+03      12      33 ..     618     640 ..     614     655 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.3
     Kelch_2   1 rrgghsssvp.............ggkiyvvGGa 20 
                 +++gh+s+v+             ++ i ++GG+
  EFC36731.1 103 PLSGHASCVLdclisssnniddnESIIAFMGGI 135
                 578999999955555555555555555555555 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 5e-06
     Kelch_2  14 iyvvGGahtdnpnlsssdvhvldlekhvWeevtplg 49 
                 i+++GG+   ++    +dv++l+le+ +W e++ +g
  EFC36731.1 305 ILIFGGI--ADKKIRLNDVWFLNLETMTWHEGKLKG 338
                 89*****..**********************98776 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0012
     Kelch_2   1 rrgghsss.vpggkiyvvGGahtdnpnlsssdvhvldl 37 
                 +r+ hs +  +++ i+++GG+    ++++ +d++ l+ 
  EFC36731.1 407 ARYYHSLTpISNNSILLYGGY----DGSFRNDMWLLNI 440
                 58999999556**********....6677777766664 PP

  == domain 4  score: 23.5 bits;  conditional E-value: 2.1e-08
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 +r+ h +  + +ki+++GG+   +++  ++d++ +d ++++W+++
  EFC36731.1 480 PRYNHWCGLVKDKILLFGGV--LEKGIQTNDLWLFDIDSYRWKNL 522
                 79******************..********************985 PP

  == domain 5  score: 10.7 bits;  conditional E-value: 0.00022
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44 
                 rr+ h ++v+g  +++vGG+    + l+ +   vldle+ +W++
  EFC36731.1 535 RRSDHKCVVLGKFLILVGGV---YKKLYLNNTFVLDLETLQWKK 575
                 799*****************...9999999999*********86 PP

  == domain 6  score: -1.0 bits;  conditional E-value: 1.1
     Kelch_2  12 gkiyvvGGa.........htdnpnlsssdvh 33 
                 gk +++GG+                  +d++
  EFC36731.1 618 GKALIFGGIvdkdklvarA--------NDMW 640
                 8889*****8444444442........3333 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.1     0.035        62      35      48 ..      98     111 ..      69     112 .. 0.74
   2 ?    2.1   0.0      0.14   2.5e+02       8      28 ..     133     152 ..     129     163 .. 0.86
   3 !   13.3   0.0   4.3e-05     0.077       3      33 ..     304     333 ..     303     351 .. 0.84
   4 ?    1.6   0.0      0.21   3.7e+02      37      47 ..     404     414 ..     366     416 .. 0.86
   5 !    5.9   0.3    0.0089        16       1      33 [.     418     452 ..     418     484 .. 0.70
   6 !   15.4   0.0   9.4e-06     0.017       2      41 ..     491     536 ..     490     544 .. 0.76
   7 !    5.9   0.1    0.0087        16       4      32 ..     548     574 ..     545     606 .. 0.82
   8 ?    3.5   0.0      0.05        89       3      28 ..     619     648 ..     617     663 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.035
     Kelch_3  35 aslppaRaghaata 48 
                  + pp+ +gha+++
  EFC36731.1  98 TDIPPPLSGHASCV 111
                 577**********7 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.14
     Kelch_3   8 GGlgddgqdrlndvyvydldt 28 
                 GG   +g +r n+v+++++ t
  EFC36731.1 133 GGIS-IGFKRINNVWLFSPKT 152
                 7777.788999*******987 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 4.3e-05
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydldtntWae 33 
                 +++ifGG   d   rlndv+ ++l+t tW e
  EFC36731.1 304 FILIFGGIA-DKKIRLNDVWFLNLETMTWHE 333
                 589******.79*****************85 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.21
     Kelch_3  37 lppaRaghaat 47 
                  p+aR++h++t
  EFC36731.1 404 IPTARYYHSLT 414
                 599******99 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.0089
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydl..dtn...tWae 33 
                 +++++++GG++   + + nd++++++   +n   +W++
  EFC36731.1 418 NNSILLYGGYD---GSFRNDMWLLNIldYKNfifEWKK 452
                 689********...9999****9998643335666664 PP

  == domain 6  score: 15.4 bits;  conditional E-value: 9.4e-06
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWaei.......aslppaR 41 
                 d++++fGG     +  +nd++++d+d+  W+++        + p  R
  EFC36731.1 491 DKILLFGGVL-EKGIQTNDLWLFDIDSYRWKNLlpdrdpsEDYPERR 536
                 8999****99.68999***************8887444333334455 PP

  == domain 7  score: 5.9 bits;  conditional E-value: 0.0087
     Kelch_3   4 lyifGGlgddgqdrlndvyvydldtntWa 32 
                 l ++GG       +ln+++v+dl+t +W+
  EFC36731.1 548 LILVGGVY--KKLYLNNTFVLDLETLQWK 574
                 56666666..67789*************9 PP

  == domain 8  score: 3.5 bits;  conditional E-value: 0.05
     Kelch_3   3 rlyifGGlgd.dg.qdrlndvyvy..dldt 28 
                 +++ifGG  d d    r nd++++  +l+ 
  EFC36731.1 619 KALIFGGIVDkDKlVARANDMWLLetNLNE 648
                 799******754455666****99444455 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       3.9   6.9e+03      25      36 ..     141     152 ..     140     152 .. 0.86
   2 !    8.0   0.0    0.0012       2.1      14      41 ..     305     333 ..     291     335 .. 0.94
   3 ?    3.0   0.1     0.043        76       9      33 ..     416     439 ..     408     443 .. 0.79
   4 !    9.9   0.0   0.00029      0.52       1      41 [.     480     521 ..     480     522 .. 0.94
   5 !   15.3   0.0     6e-06     0.011       1      41 [.     535     575 ..     535     578 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.9
                 BEEEEEEEETTT CS
     Kelch_1  25 alssvevyDpet 36 
                 + ++v+ ++p+t
  EFC36731.1 141 RINNVWLFSPKT 152
                 6799*****997 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0012
                 EEEEEEBCS.SSBEEEEEEEETTTTEEEE CS
     Kelch_1  14 iYviGGsdg.gnalssvevyDpetntWre 41 
                 i ++GG  +   +l++v+ +++et tW+e
  EFC36731.1 305 ILIFGGIADkKIRLNDVWFLNLETMTWHE 333
                 789************************98 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.043
                 EETTEEEEEEEBCSSSBEEEEEEEE CS
     Kelch_1   9 vvggkiYviGGsdggnalssvevyD 33 
                   ++ i   GG+dg ++ ++ + ++
  EFC36731.1 416 ISNNSILLYGGYDG-SFRNDMWLLN 439
                 6799**********.7777777665 PP

  == domain 4  score: 9.9 bits;  conditional E-value: 0.00029
                 BBBSEEEEEETTEEEEEEEBCS.SSBEEEEEEEETTTTEEEE CS
     Kelch_1   1 aragagavvvggkiYviGGsdg.gnalssvevyDpetntWre 41 
                 +r+++ +  v +ki  +GG  + g  +++++ +D  +  W  
  EFC36731.1 480 PRYNHWCGLVKDKILLFGGVLEkGIQTNDLWLFDIDSYRWKN 521
                 689999999*******************************86 PP

  == domain 5  score: 15.3 bits;  conditional E-value: 6e-06
                 BBBSEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEE CS
     Kelch_1   1 aragagavvvggkiYviGGsdggnalssvevyDpetntWre 41 
                 +r+ + +vv+g  +  +GG     +l++ +v+D+et +W +
  EFC36731.1 535 RRSDHKCVVLGKFLILVGGVYKKLYLNNTFVLDLETLQWKK 575
                 79*************************************86 PP

>> Phe_tRNA-synt_N  Aminoacyl tRNA synthetase class II, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.5   0.00022       0.4      30      66 ..     989    1028 ..     985    1030 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00022
                       CCCCTTTHHHHCCHH...HHCCCCCCCCCHHHCCHCCHHH CS
  Phe_tRNA-synt_N   30 lppeeRkeaGkliNe...lKqeieealeerkeeleaaele 66  
                       + pe+R+ a +++N+   lK+++e+ l+++ e ++ ++++
       EFC36731.1  989 IEPEKRPSASQIVNKlnnLKERVENILNDKLETIKINAMN 1028
                       679*******987652227**************9988876 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       4.4   7.9e+03      28      73 ..     711     758 ..     701     768 .. 0.76
   2 ?   10.3   0.0   0.00019      0.33     124     156 ..     836     868 ..     815     874 .. 0.84

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 4.4
         Kdo  28 vnaalrkyyrggllgklskdlyrfk..lgrtravrEfrllkrLeeagv 73 
                 +n   +kyy  + +  ++ d++ ++  +    +++E+ +l++L+++ +
  EFC36731.1 711 GNISTSKYYALKRMDIIFNDNVGRNksVASDSVFNEILILQQLKHVNI 758
                 567778888888888888887765546777788999999999987765 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00019
         Kdo 124 lkavgrliaklhragvnHadlyaknillqqeee 156
                 l +++ + + +h++++ H+dl + ni++  e++
  EFC36731.1 836 LIQIALALEYIHERNIIHRDLKPSNIFVTFENS 868
                 6699************************98874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2519  (0.140499); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.18u 0.32s 00:00:01.50 Elapsed: 00:00:00.54
# Mc/sec: 6958.55
//
Query:       EFC36732.1  [L=438]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.015   15.2   0.1      0.048   13.6   0.1    2.0  1  EHD_N     N-terminal EH-domain containing protein


Domain annotation for each model (and alignments):
>> EHD_N  N-terminal EH-domain containing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1   2.6e-06     0.048      10      26 ..     130     146 ..     127     148 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.6e-06
       EHD_N  10 lkPLEeaYkFdeFhspl 26 
                 + PLE++Y +deF s +
  EFC36732.1 130 MIPLETEYLYDEFDSEQ 146
                 67***********9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (438 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       794  (0.0442858); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.25s 00:00:00.74 Elapsed: 00:00:00.42
# Mc/sec: 3127.51
//
Query:       EFC36733.1  [L=142]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      3e-53  179.8   0.0    3.6e-53  179.5   0.0    1.0  1  Y_phosphatase2  Tyrosine phosphatase family
    6.6e-09   36.1   0.0    7.5e-09   35.9   0.0    1.2  1  Y_phosphatase3  Tyrosine phosphatase family
    0.00028   20.7   0.0    0.00029   20.6   0.0    1.3  1  DSPc            Dual specificity phosphatase, catalytic domai
    0.00043   19.9   0.0    0.00049   19.7   0.0    1.1  1  Y_phosphatase   Protein-tyrosine phosphatase


Domain annotation for each model (and alignments):
>> Y_phosphatase2  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  179.5   0.0     8e-57   3.6e-53      12     147 ..       2     137 ..       1     141 [. 0.98

  Alignments for each domain:
  == domain 1  score: 179.5 bits;  conditional E-value: 8e-57
                     TTEEEESS--HHHHHHHHHCT-SEEEE-SSS---HHHHHHHHHCT-EEEE-------GGG----HHHHHHHHHHHH-GGG-SEEEE-SSSSSHHH CS
  Y_phosphatase2  12 selyrssyprasnfsflksLkLktiislspeeesqdelqfleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckrGkhrtg 106
                     ++++rs+yp+++nf+flk++ Lk+i +l+pe+++++++ f+ +  i+ +++ ie+nke++v+i++d ++ka+  lln +n+p+l+hc++Gkhrtg
      EFC36733.1   2 PGVFRSGYPNKKNFPFLKKIGLKSICYLCPEQYAHNNMEFCRKVGIRIFQFGIEGNKEPFVHIPEDAIRKAITELLNPKNHPILIHCNKGKHRTG 96 
                     579******************************************************************************************** PP

                     HHHHHHHHHTTB-HHHHHHHHHHHHCCC--HHHHHHHHC-- CS
  Y_phosphatase2 107 lvigclRklqkWslasilnEyrrFsgskkrivdeefienfd 147
                     +++gclRk q+Wsl+si++EyrrF+gsk r++d++fie ++
      EFC36733.1  97 VLVGCLRKTQNWSLTSIFDEYRRFAGSKVRMLDQQFIELYS 137
                     **************************************997 PP

>> Y_phosphatase3  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9   0.0   1.7e-12   7.5e-09     106     157 ..      65     118 ..      32     134 .. 0.89

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 1.7e-12
  Y_phosphatase3 106 akkayrkvfealad.ee.pvlfHCtaGKDRTGvlaalllsllGvdeedivaDYl 157
                      ++a+rk++++l++ ++ p+l+HC  GK RTGvl+  l +  + +   i+++Y 
      EFC36733.1  65 PEDAIRKAITELLNpKNhPILIHCNKGKHRTGVLVGCLRKTQNWSLTSIFDEYR 118
                     5689**********7669**********************************96 PP

>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   6.6e-08   0.00029      64     108 ..      71     115 ..       8     137 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 6.6e-08
                 HHHHHH.HHTT-EEEEEESSSSSHHHHHHHHHHHHHHTSCHHHHHH CS
        DSPc  64 efidka.kqkgkkvlVHCqaGisRSatliiaYlmktknlslneaye 108
                 + i ++   k++ +l+HC+ G  R++ l+ + l kt+n+sl + ++
  EFC36733.1  71 KAITELlNPKNHPILIHCNKGKHRTGVLVGC-LRKTQNWSLTSIFD 115
                 4444444779*******************98.88999999988776 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.0   1.1e-07   0.00049     157     191 ..      71     102 ..      51     139 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 1.1e-07
                    HHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHHH CS
  Y_phosphatase 157 klirkvekskeaksgpvvVhCsaGvgRtgtfvald 191
                    k i+++    ++k++p+++hC +G  Rtg++v   
     EFC36733.1  71 KAITELL---NPKNHPILIHCNKGKHRTGVLVGCL 102
                    3333333...5669****************99754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (142 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       409  (0.0228122); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 1027.50
//
Query:       EFC36734.1  [L=639]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.6e-51  172.2   0.7    1.7e-50  171.2   0.7    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    9.9e-16   57.8   0.0    4.2e-09   36.4   0.1    2.4  2  PAS            PAS fold
    2.7e-12   46.8   0.7    3.6e-09   36.8   0.2    2.6  2  PAS_9          PAS domain
    4.7e-06   26.8   0.0      0.007   16.6   0.0    2.3  2  PAS_4          PAS fold
    1.4e-05   24.9   0.0      0.023   14.7   0.0    2.5  2  PAS_8          PAS domain
     0.0054   17.0   0.0      0.014   15.7   0.0    1.7  2  PAS_3          PAS fold
  ------ inclusion threshold ------
      0.063   13.4   0.0        9.7    6.3   0.0    2.2  2  MLTR_LBD       MmyB-like transcription regulator ligand bindi


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  171.2   0.7   6.6e-54   1.7e-50       6     180 ..     458     633 ..     454     635 .. 0.98

  Alignments for each domain:
  == domain 1  score: 171.2 bits;  conditional E-value: 6.6e-54
  Guanylate_cyc   6 ydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskeglk 101
                    +d+ ti+F+dI++f++ls + sp++++++L +++++fd  +++++++k+ktiGd ym +sglpe++++ a+++++ a++m + ++ +++ sk +++
     EFC36734.1 458 HDQATIMFSDIENFNQLSMEISPKNLISFLDSIFEKFDVTIQKYQLEKIKTIGDNYMLASGLPEQNNNFAENAVRGAFEMAQIVSDMNKTSKFKVN 553
                    7999******************************************************************************************** PP

  Guanylate_cyc 102 vrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellk.eeqfeltergevevkGkgkletyf 180
                    v++G++tG+vvag++G+kkp ydvwG tvn Asrm+st+ +++ q+  +tye l  +   ++t+r  v+vkG g+ ety+
     EFC36734.1 554 VKIGLSTGEVVAGIVGKKKPAYDVWGATVNFASRMQSTSLTNHLQICTKTYEKLPqDLASKFTHRTGVKVKGIGTCETYI 633
                    ******************************************************988999******************97 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   4.4e-07    0.0011       9      73 ..     137     201 ..     130     237 .. 0.84
   2 !   36.4   0.1   1.6e-12   4.2e-09       6     113 .]     313     422 ..     308     422 .. 0.92

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 4.4e-07
                 HSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHH.HHHHHHHHHHHHTT-EC CS
         PAS   9 slpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheedda.elaelleqlleqgeesr 73 
                 +  +p+fvvD +++i  +N+  eel+G s +++ +k++   ++e+ +a el+++++ +l+ +++s 
  EFC36734.1 137 ACMCPVFVVDTKTNIHSMNSFGEELFGKSLKDLQSKNVCLILNEN-SAgELQKRIRDYLQLRSKSM 201
                 5568***********************************555555.55699999999998887765 PP

  == domain 2  score: 36.4 bits;  conditional E-value: 1.6e-12
                 HHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEEEEEEETT CS
         PAS   6 ileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevraspvrdag 100
                 + + ++ pi+++D   +++ +N+aae  +G++++e++g sl  +i +++ a+ + ++ +++  +  +r +++++ +    + g+++++e+  + + d +
  EFC36734.1 313 VTQLSTIPIVAIDTLSIVNTWNPAAEHVFGIRASEIIGNSLT-VIMPDEIAINHNAFVNRYIKTGIKRVVDKTRVVngkrKSGEIFPVELKITEIKDDK 410
                 5566889***********************************.55555566************************************************ PP

                 EEEEEEEEEEEES CS
         PAS 101 geilgflgvlrdi 113
                 +++  flg++rd+
  EFC36734.1 411 DQR-IFLGFARDM 422
                 *98.9******96 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0015       3.7       3      73 ..     141     231 ..     139     251 .. 0.71
   2 !   36.8   0.2   1.4e-12   3.6e-09       9     104 .]     325     424 ..     319     424 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0015
       PAS_9   3 gilidnpdgrilyaNeaalrllGyspeevlgksitdlf..vtdpeanerlraaleqgrk..................kerevevvlirkng 73 
                 ++++++++ +i ++N   ++l+G s +++  k++  ++   ++ e ++r+r++l+  +k                  k   v ++++ kng
  EFC36734.1 141 PVFVVDTKTNIHSMNSFGEELFGKSLKDLQSKNVCLILneNSAGELQKRIRDYLQLRSKsmlaekvvydikdpktpiKKVGVRITEMIKNG 231
                 6788788888999**********99999999997666677777888888888888888655555555555555555544444444444444 PP

  == domain 2  score: 36.8 bits;  conditional E-value: 1.4e-12
       PAS_9   9 pdgril.yaNeaalrllGyspeevlgksitdlf..vtdpeanerlraaleqgrk..kerevevvlirkngetfwvlltaspvkdd.dgelvgiivilrD 101
                 +   i+  +N+aa+ ++G  + e++g s+t ++  + + ++n ++++++++g k    +++ v   rk+ge f+v+l+++ +kdd d+++++  ++ rD
  EFC36734.1 325 DTLSIVnTWNPAAEHVFGIRASEIIGNSLTVIMpdEIAINHNAFVNRYIKTGIKrvVDKTRVVNGKRKSGEIFPVELKITEIKDDkDQRIFL--GFARD 421
                 4456999**************************99888888888888888888888889999999********************7777777..***** PP

       PAS_9 102 ite 104
                 +t+
  EFC36734.1 422 MTA 424
                 *95 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0    0.0014       3.6       6      60 ..     140     194 ..     135     211 .. 0.86
   2 !   16.6   0.0   2.8e-06     0.007       6     107 ..     319     424 ..     315     427 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0014
       PAS_4   6 dalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvl 60 
                 ++++v+d+  ++  +N  ++elfg + ++l  k +  +l+e +a++l+  +r  l
  EFC36734.1 140 CPVFVVDTKTNIHSMNSFGEELFGKSLKDLQSKNVCLILNENSAGELQKRIRDYL 194
                 799****************************999998888888888887777555 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 2.8e-06
       PAS_4   6 dalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvlege..epiefleelll...pgeerhyelrllPlrdesGevigvl 99 
                  +++++d+ + v  +N+aa+++fg+++ e++G +l  ++p+e a ++ + ++r ++++  ++++ + +++    +ge  ++el ++ ++d++ + + +l
  EFC36734.1 319 IPIVAIDTLSIVNTWNPAAEHVFGIRASEIIGNSLTVIMPDEIAINHNAFVNRYIKTGikRVVDKTRVVNGkrkSGEIFPVELKITEIKDDKDQ-RIFL 416
                 57889999999*******************************9999999999999996446777777777798999999*********886666.8899 PP

       PAS_4 100 visrDiTe 107
                 +++rD+T+
  EFC36734.1 417 GFARDMTA 424
                 99999997 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0    0.0015       3.9      13      43 ..     141     172 ..     139     197 .. 0.72
   2 !   14.7   0.0   8.9e-06     0.023       2      50 ..     309     358 ..     308     368 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0015
       PAS_8  13 giavvdlgdrivdvNqaalellGys.adlkge 43 
                 +++vvd+ ++i  +N   +el+G s +dl  +
  EFC36734.1 141 PVFVVDTKTNIHSMNSFGEELFGKSlKDLQSK 172
                 799***5557*************774444433 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 8.9e-06
       PAS_8   2 rlralfesspdgiavvdlgd..rivdvNqaalellGys.adlkgellgqllp 50 
                 ++ a+   s  +i+ +d  +   +  +N+aa++ +G +  +++g  l +++p
  EFC36734.1 309 FHSAVTQLSTIPIVAID--TlsIVNTWNPAAEHVFGIRaSEIIGNSLTVIMP 358
                 55666667778999999..5446999**********7777777666654444 PP

>> PAS_3  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0         7   1.8e+04       9      22 ..     159     172 ..     154     178 .. 0.82
   2 !   15.7   0.0   5.4e-06     0.014       3      83 ..     332     414 ..     330     419 .. 0.79

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 7
       PAS_3   9 eeilGyspeellgk 22 
                 ee++G s  +l++k
  EFC36734.1 159 EELFGKSLKDLQSK 172
                 78999999999987 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 5.4e-06
       PAS_3   3 yvserveeilGyspeellgkveswldlvhpeDrervrealq.ealkkge.pyegeyRi...rrkdGeyrwveararvirdengkpv 83 
                 +++++ e+++G++++e++g+    l ++ p++++   +a+  +++k+g  ++    R+   +rk+Ge++ ve +++ i+d++ + +
  EFC36734.1 332 TWNPAAEHVFGIRASEIIGN---SLTVIMPDEIAINHNAFVnRYIKTGIkRVVDKTRVvngKRKSGEIFPVELKITEIKDDKDQRI 414
                 7*******************...889999999666666654399****9766555555222789**************88877765 PP

>> MLTR_LBD  MmyB-like transcription regulator ligand binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.0    0.0038       9.7      15      44 ..     140     170 ..     136     199 .. 0.82
   2 ?    4.7   0.0     0.012        30       8      38 ..     312     342 ..     308     356 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0038
    MLTR_LBD  15 vPAlVldrrwdvlaaNraaraLlgd.paalp 44 
                 +P++V+d + ++  +N  ++ L+g  +++l+
  EFC36734.1 140 CPVFVVDTKTNIHSMNSFGEELFGKsLKDLQ 170
                 69**********************9544443 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.012
    MLTR_LBD   8 lLdalepvPAlVldrrwdvlaaNraaraLlg 38 
                  +++l++ P + +d    v  +N+aa+ ++g
  EFC36734.1 312 AVTQLSTIPIVAIDTLSIVNTWNPAAEHVFG 342
                 6899************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (639 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1563  (0.0871772); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.76u 0.29s 00:00:01.05 Elapsed: 00:00:00.52
# Mc/sec: 3682.45
//
Query:       EFC36735.1  [L=287]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-55  184.8  10.3    2.4e-09   37.5   0.0    6.1  6  Sel1      Sel1 repeat
    1.6e-07   31.5   4.5       0.17   12.6   0.0    5.4  5  TPR_6     Tetratricopeptide repeat
     0.0049   16.5  18.6        1.4    8.7   0.0    6.7  7  TPR_11    TPR repeat
  ------ inclusion threshold ------
       0.01   16.2   0.7        1.9    8.9   0.0    3.0  2  DUF3837   Domain of unknown function (DUF3837)
      0.022   14.7   2.2        4.5    7.5   0.1    4.1  4  TPR_7     Tetratricopeptide repeat
      0.033   14.1   0.0       0.17   11.8   0.0    2.1  2  DUF977    Bacterial protein of unknown function (DUF977)
      0.034   14.3  18.7        2.7    8.3   0.3    7.8  9  TPR_2     Tetratricopeptide repeat
       0.16   11.9  27.7        1.6    8.7   0.2    8.6 11  TPR_1     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.5   0.0   1.1e-12   2.4e-09       1      38 []      13      49 ..      13      49 .. 0.92
   2 !   34.8   0.1   8.2e-12   1.8e-08       1      38 []      50      85 ..      50      85 .. 0.94
   3 !   19.4   0.0   5.6e-07    0.0013       1      37 [.      86     127 ..      86     128 .. 0.88
   4 !   30.3   0.1     2e-10   4.6e-07       2      38 .]     130     164 ..     129     164 .. 0.89
   5 !   32.1   0.0   5.4e-11   1.2e-07       1      38 []     165     201 ..     165     201 .. 0.93
   6 !   33.1   0.2   2.8e-11   6.3e-08       3      38 .]     204     238 ..     202     238 .. 0.93

  Alignments for each domain:
  == domain 1  score: 37.5 bits;  conditional E-value: 1.1e-12
        Sel1  1 aeAmyrLGmfylylnGlg.vpkDpekAiewyekAAeqGd 38
                ++A+y+LG  ++y+nG   + ++ ekA+e++ek+A qG+
  EFC36735.1 13 SAAQYNLG--LIYYNGNSnISRNLEKAVELFEKSALQGN 49
                68******..777****66******************97 PP

  == domain 2  score: 34.8 bits;  conditional E-value: 8.2e-12
        Sel1  1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                ++A+yr G   +y++G  +   +ekA+ewy+k+ +qG+
  EFC36735.1 50 SDAQYRIG--IMYEEGEFLLESQEKAFEWYKKSSDQGH 85
                68******..777****99999***************9 PP

  == domain 3  score: 19.4 bits;  conditional E-value: 5.6e-07
        Sel1   1 aeAmyrLGmfylylnGl.......gvpkDpekAiewyekAAeqG 37 
                 a+A+y  G   ly+ G        g+  +++ A+e+yek+ +q+
  EFC36735.1  86 AHAQYSIG--VLYEQGIpnsptfaGIQSNYSIAFEYYEKSSMQN 127
                 68******..888****98888777777************9996 PP

  == domain 4  score: 30.3 bits;  conditional E-value: 2e-10
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 eA y+LG  ++y+ G+g+ +  ekA+e++ekAA+q d
  EFC36735.1 130 EAFYNLG--LMYELGKGTTASLEKALECFEKAAQQSD 164
                 666****..666*********************9975 PP

  == domain 5  score: 32.1 bits;  conditional E-value: 5.4e-11
        Sel1   1 aeAmyrLGmfylylnGlg.vpkDpekAiewyekAAeqGd 38 
                 a+A+++LG+f+   +G   v+kD  +A+ew++k+A qG+
  EFC36735.1 165 ADAQCKLGLFC--KDGNRiVKKDLTRAFEWFQKSALQGN 201
                 68******888..****66******************97 PP

  == domain 6  score: 33.1 bits;  conditional E-value: 2.8e-11
        Sel1   3 AmyrLGmfylylnGlg.vpkDpekAiewyekAAeqGd 38 
                 A++ L+ fy  l+G g ++k ++ A+ewy+kAA+qG+
  EFC36735.1 204 AQCELANFY--LKGVGgIEKSEKVALEWYRKAANQGN 238
                 9*****888..****66*******************7 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   7.7e-05      0.17       2      25 ..      15      43 ..      14      44 .. 0.94
   2 ?    3.3   0.0     0.071   1.6e+02       1      13 [.      51      63 ..      51      75 .. 0.87
   3 ?    1.8   0.0      0.21   4.8e+02       2      25 ..      88     122 ..      87     122 .. 0.81
   4 !    9.2   0.2   0.00094       2.1       1      28 [.     130     161 ..     130     164 .. 0.77
   5 ?    1.2   0.0      0.33   7.5e+02      13      28 ..     236     250 ..     225     251 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 7.7e-05
                HHHHHHHHHHHH.....HHHHHHHHHHHH CS
       TPR_6  2 Alyklalsyrkl.....gdtdkAlealer 25
                A+y+l+l y+++      + +kA+e++e+
  EFC36735.1 15 AQYNLGLIYYNGnsnisRNLEKAVELFEK 43
                99*********88***99*********97 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.071
                HHHHHHHHHHHHH CS
       TPR_6  1 dAlyklalsyrkl 13
                dA+y+++  y+++
  EFC36735.1 51 DAQYRIGIMYEEG 63
                8*********986 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.21
                 HHHHHHHHHHHH...........HHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl...........gdtdkAlealer 25 
                 A+y ++ +y+++            +++ A e++e+
  EFC36735.1  88 AQYSIGVLYEQGipnsptfagiqSNYSIAFEYYEK 122
                 89999****99878888888886688888888875 PP

  == domain 4  score: 9.2 bits;  conditional E-value: 0.00094
                 HHHHHHHHHHHHH....HHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtdkAlealerlik 28 
                 +A+y+l+l y+ +       +kAle +e+  +
  EFC36735.1 130 EAFYNLGLMYELGkgttASLEKALECFEKAAQ 161
                 79*********984553344599999999766 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.33
                 HHHHHHHHHHHHHHHH CS
       TPR_6  13 lgdtdkAlealerlik 28 
                 +g+  +A+++l++l k
  EFC36735.1 236 QGNF-DAKTYLRSLTK 250
                 2444.6******9987 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   1.5     0.011        26      30      40 ..      15      25 ..      14      26 .. 0.87
   2 ?   -2.7   0.0       2.3   5.1e+03      10      18 ..      34      42 ..      33      45 .. 0.61
   3 ?   -3.3   0.0       3.4   7.6e+03      29      38 ..      51      60 ..      49      62 .. 0.73
   4 ?    1.6   0.4     0.098   2.2e+02      10      38 ..      70      96 ..      64      99 .. 0.59
   5 !    6.6   0.1    0.0027       6.1      28      39 ..     129     140 ..     126     142 .. 0.80
   6 !    8.7   0.0   0.00061       1.4      10      36 ..     149     173 ..     148     176 .. 0.89
   7 ?    1.6   0.1       0.1   2.3e+02      13      22 ..     226     235 ..     225     245 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.011
      TPR_11 30 ayynLGlayyk 40
                a ynLGl+yy+
  EFC36735.1 15 AQYNLGLIYYN 25
                79********4 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.3
      TPR_11 10 yeeAieaYk 18
                +e+A+e ++
  EFC36735.1 34 LEKAVELFE 42
                667776555 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 3.4
      TPR_11 29 eayynLGlay 38
                +a y +G  y
  EFC36735.1 51 DAQYRIGIMY 60
                7889999777 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.098
      TPR_11 10 yeeAieaYkkAlkldPdnaeayynLGlay 38
                 e+A e+Ykk    d+  a a y +G++y
  EFC36735.1 70 QEKAFEWYKKSS--DQGHAHAQYSIGVLY 96
                577777777754..333455667777555 PP

  == domain 5  score: 6.6 bits;  conditional E-value: 0.0027
      TPR_11  28 aeayynLGlayy 39 
                 +ea+ynLGl y 
  EFC36735.1 129 PEAFYNLGLMYE 140
                 9*******8775 PP

  == domain 6  score: 8.7 bits;  conditional E-value: 0.00061
      TPR_11  10 yeeAieaYkkAlkldPdnaeayynLGl 36 
                 +e+A+e+++kA +  +++a+a ++LGl
  EFC36735.1 149 LEKALECFEKAAQ--QSDADAQCKLGL 173
                 89*********98..689999999996 PP

  == domain 7  score: 1.6 bits;  conditional E-value: 0.1
      TPR_11  13 AieaYkkAlk 22 
                 A+e+Y+kA +
  EFC36735.1 226 ALEWYRKAAN 235
                 99******76 PP

>> DUF3837  Domain of unknown function (DUF3837)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.0   0.00086       1.9      16      57 ..      41      81 ..      29      98 .. 0.88
   2 ?    4.6   0.1     0.019        42      16      47 ..     120     151 ..     115     171 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00086
     DUF3837 16 fekailtgnyElayalGllakllglpeieekeeleelkekle 57
                fek+ l+gn  + y +G++ ++  +  +e +e+ +e+++k +
  EFC36735.1 41 FEKSALQGNSDAQYRIGIMYEEGEF-LLESQEKAFEWYKKSS 81
                789******************9999.9999999999998765 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.019
     DUF3837  16 fekailtgnyElayalGllakllglpeieeke 47 
                 +ek+ +++  E++y lGl+ +l +  +++ ++
  EFC36735.1 120 YEKSSMQNVPEAFYNLGLMYELGKGTTASLEK 151
                 5789***************9987664433333 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.1     0.002       4.5       4      26 ..      18      45 ..      17      55 .. 0.80
   2 ?   -3.7   0.0       7.5   1.7e+04      21      32 ..      95     104 ..      93     105 .. 0.74
   3 ?   -2.5   0.0       3.2   7.2e+03      18      24 ..     116     122 ..     110     125 .. 0.72
   4 ?    3.9   0.2     0.029        65      16      29 ..     150     161 ..     131     170 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.002
       TPR_7  4 nLarlysr.....lGdyeeAielyeqsL 26
                nL+ +y +      ++ e+A+el+e+s 
  EFC36735.1 18 NLGLIYYNgnsniSRNLEKAVELFEKSA 45
                7888888888888999**********54 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 7.5
       TPR_7  21 lyeqsLaltkdp 32 
                 lyeq  ++ ++p
  EFC36735.1  95 LYEQ--GIPNSP 104
                 6899..777666 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 3.2
       TPR_7  18 Aielyeq 24 
                 A e+ye+
  EFC36735.1 116 AFEYYEK 122
                 6689998 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.029
       TPR_7  16 eeAielyeqsLalt 29 
                 e+A+e++e+  a  
  EFC36735.1 150 EKALECFEK--AAQ 161
                 89*******..544 PP

>> DUF977  Bacterial protein of unknown function (DUF977)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0         1   2.3e+03      52      77 ..      55      80 ..      16      93 .. 0.57
   2 ?   11.8   0.0   7.6e-05      0.17      21      89 ..     175     247 ..     162     256 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1
      DUF977 52 erGdlirpGkyGvfrdervvrvwrka 77
                  G ++ +G + +  +e+++  ++k+
  EFC36735.1 55 RIGIMYEEGEFLLESQEKAFEWYKKS 80
                33556666666666666676644444 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 7.6e-05
      DUF977  21 vkkneritisdleritGvgrtsvrk.ylvdvlerGdlirpGkyGvfrdervvrvw.rkaaekat..dqtlirk 89 
                  k+ +ri  +dl r++   ++s+ +   +   e  +++ +G  G+ ++e+v   w rkaa++     +t +r 
  EFC36735.1 175 CKDGNRIVKKDLTRAFEWFQKSALQgNDRAQCELANFYLKGVGGIEKSEKVALEWyRKAANQGNfdAKTYLRS 247
                 466789**********988888765156778999****************99887588888754213455555 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.2     0.031        69       2      13 ..      14      25 ..      13      28 .. 0.87
   2 ?    4.0   0.0     0.029        65      15      27 ..      32      44 ..      30      47 .. 0.87
   3 ?   -2.2   0.0       2.9   6.4e+03       2      12 ..      51      61 ..      50      63 .. 0.82
   4 ?   -1.9   0.1       2.3   5.2e+03      18      26 ..      71      79 ..      65      80 .. 0.80
   5 ?   -0.4   0.0      0.72   1.6e+03      16      26 ..     112     122 ..     110     125 .. 0.83
   6 ?    2.0   0.0      0.12   2.8e+02       1      12 [.     129     140 ..     129     143 .. 0.88
   7 ?    8.3   0.3    0.0012       2.7      17      30 ..     149     162 ..     148     166 .. 0.86
   8 ?   -0.6   0.0       0.9     2e+03      15      27 ..     184     196 ..     181     198 .. 0.84
   9 ?    0.7   0.0      0.34   7.5e+02      20      28 ..     226     234 ..     224     238 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.031
       TPR_2  2 ealynlGlayyk 13
                 a ynlGl+yy+
  EFC36735.1 14 AAQYNLGLIYYN 25
                589*******97 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.029
       TPR_2 15 gdyeeAleafekA 27
                 ++e+A+e+fek+
  EFC36735.1 32 RNLEKAVELFEKS 44
                699********96 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 2.9
       TPR_2  2 ealynlGlayy 12
                +a y++G  y+
  EFC36735.1 51 DAQYRIGIMYE 61
                68899999996 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 2.3
       TPR_2 18 eeAleafek 26
                e+A e+++k
  EFC36735.1 71 EKAFEWYKK 79
                789999987 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.72
       TPR_2  16 dyeeAleafek 26 
                 +y  A e++ek
  EFC36735.1 112 NYSIAFEYYEK 122
                 78889999998 PP

  == domain 6  score: 2.0 bits;  conditional E-value: 0.12
       TPR_2   1 aealynlGlayy 12 
                 +ea ynlGl y+
  EFC36735.1 129 PEAFYNLGLMYE 140
                 699******996 PP

  == domain 7  score: 8.3 bits;  conditional E-value: 0.0012
       TPR_2  17 yeeAleafekAlel 30 
                 +e+Ale+fekA + 
  EFC36735.1 149 LEKALECFEKAAQQ 162
                 59*********986 PP

  == domain 8  score: -0.6 bits;  conditional E-value: 0.9
       TPR_2  15 gdyeeAleafekA 27 
                 +d+ +A e+f+k+
  EFC36735.1 184 KDLTRAFEWFQKS 196
                 7889999***996 PP

  == domain 9  score: 0.7 bits;  conditional E-value: 0.34
       TPR_2  20 AleafekAl 28 
                 Ale+++kA 
  EFC36735.1 226 ALEWYRKAA 234
                 9999*9996 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.9      0.01        23       2      13 ..      14      25 ..      13      27 .. 0.87
   2 ?    2.2   0.0     0.079   1.8e+02      16      26 ..      33      43 ..      31      45 .. 0.86
   3 ?    0.2   0.0      0.34   7.7e+02       2      12 ..      51      61 ..      50      62 .. 0.86
   4 ?   -1.5   0.1       1.2   2.6e+03      18      26 ..      71      79 ..      65      80 .. 0.82
   5 ?   -1.3   0.0      0.98   2.2e+03       3      13 ..      88      98 ..      86      98 .. 0.83
   6 ?    1.6   0.0      0.13   2.9e+02      14      26 ..     110     122 ..     108     123 .. 0.87
   7 ?    5.7   0.0    0.0064        14       1      12 [.     129     140 ..     129     142 .. 0.89
   8 ?    8.7   0.2   0.00071       1.6      17      28 ..     149     160 ..     148     163 .. 0.87
   9 ?   -3.0   0.0       3.5   7.9e+03      15      26 ..     184     195 ..     183     196 .. 0.79
  10 ?   -2.6   0.1       2.7     6e+03       3      13 ..     204     214 ..     203     214 .. 0.82
  11 ?   -0.3   0.2       0.5   1.1e+03      20      27 ..     226     233 ..     226     234 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.01
                HHHHHHHHHHHH CS
       TPR_1  2 kalynlGnayfk 13
                 a ynlG++y++
  EFC36735.1 14 AAQYNLGLIYYN 25
                589*******96 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.079
                -HHHHHHHHHH CS
       TPR_1 16 kydeAleyyek 26
                ++++A+e +ek
  EFC36735.1 33 NLEKAVELFEK 43
                789****9999 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.34
                HHHHHHHHHHH CS
       TPR_1  2 kalynlGnayf 12
                +a y++G +y 
  EFC36735.1 51 DAQYRIGIMYE 61
                799******96 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 1.2
                HHHHHHHHH CS
       TPR_1 18 deAleyyek 26
                ++A e y+k
  EFC36735.1 71 EKAFEWYKK 79
                899999998 PP

  == domain 5  score: -1.3 bits;  conditional E-value: 0.98
                HHHHHHHHHHH CS
       TPR_1  3 alynlGnayfk 13
                a y +G++y +
  EFC36735.1 88 AQYSIGVLYEQ 98
                7899****975 PP

  == domain 6  score: 1.6 bits;  conditional E-value: 0.13
                 TT-HHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyek 26 
                 + +y  A eyyek
  EFC36735.1 110 QSNYSIAFEYYEK 122
                 679999******9 PP

  == domain 7  score: 5.7 bits;  conditional E-value: 0.0064
                 HHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayf 12 
                 ++a+ynlG++y 
  EFC36735.1 129 PEAFYNLGLMYE 140
                 58********96 PP

  == domain 8  score: 8.7 bits;  conditional E-value: 0.00071
                 HHHHHHHHHHHH CS
       TPR_1  17 ydeAleyyekAL 28 
                 +++Ale++ekA 
  EFC36735.1 149 LEKALECFEKAA 160
                 59*********6 PP

  == domain 9  score: -3.0 bits;  conditional E-value: 3.5
                 T-HHHHHHHHHH CS
       TPR_1  15 gkydeAleyyek 26 
                 +++  A e ++k
  EFC36735.1 184 KDLTRAFEWFQK 195
                 677889999998 PP

  == domain 10  score: -2.6 bits;  conditional E-value: 2.7
                 HHHHHHHHHHH CS
       TPR_1   3 alynlGnayfk 13 
                 a + l+n y+k
  EFC36735.1 204 AQCELANFYLK 214
                 78999999986 PP

  == domain 11  score: -0.3 bits;  conditional E-value: 0.5
                 HHHHHHHH CS
       TPR_1  20 AleyyekA 27 
                 Ale y+kA
  EFC36735.1 226 ALEWYRKA 233
                 89999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (287 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       583  (0.0325172); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1856.84
//
Query:       EFC36736.1  [L=1071]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-24   85.1   0.8     0.0017   18.3   0.0    9.6 11  NHL             NHL repeat
    1.5e-09   38.1  62.2      0.006   16.9   9.9    5.0  5  EGF_2           EGF-like domain
    1.2e-05   25.1   2.8        1.3    8.6   0.2    4.8  5  SGL             SMP-30/Gluconolactonase/LRE-like region
     0.0031   17.7   5.1        2.9    8.2   0.0    5.1  5  Arylesterase    Arylesterase
     0.0034   17.7   1.8     0.0093   16.3   0.8    2.3  2  DUF3997         Protein of unknown function (DUF3997)
     0.0056   16.3   0.7       0.14   11.8   0.2    2.1  2  Virul_fac_BrkB  Virulence factor BrkB
  ------ inclusion threshold ------
       0.73    9.9   6.4        1.1    9.3   0.3    3.6  3  SBBP            Beta-propeller repeat
        1.1    9.3   8.0       0.33   10.9   0.8    2.5  2  SHP             Small hydrophobic protein


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.0    0.0054        12       2      27 ..      71      96 ..      70      97 .. 0.93
   2 !    7.7   0.0    0.0017       3.8       1      25 [.     170     194 ..     170     196 .. 0.85
   3 !   18.3   0.0   7.5e-07    0.0017       1      27 [.     223     250 ..     223     251 .. 0.91
   4 ?   -3.4   0.0       5.9   1.3e+04       4      16 ..     283     295 ..     283     295 .. 0.87
   5 ?    2.1   0.0       0.1   2.3e+02       1      19 [.     336     355 ..     336     362 .. 0.82
   6 ?   -3.6   0.1       6.8   1.5e+04      10      19 ..     420     429 ..     419     430 .. 0.78
   7 ?    0.7   0.1      0.28   6.3e+02       3      16 ..     463     476 ..     462     476 .. 0.91
   8 !   13.9   0.0   1.8e-05     0.041      11      27 ..     585     601 ..     582     602 .. 0.91
   9 !   18.1   0.0   8.6e-07    0.0019       2      27 ..     648     673 ..     647     674 .. 0.92
  10 ?    4.3   0.0      0.02        45       4      20 ..     707     723 ..     706     724 .. 0.91
  11 ?   -2.8   0.1       3.7   8.2e+03       8      17 ..     827     836 ..     827     837 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0054
                SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  2 nyPhGvavdsnGdiyVaDsenhrvqv 27
                n+P+G+ v+s+G  y+a++ + r+++
  EFC36736.1 71 NSPSGIHVTSDGTMYIAEYTSKRIRK 96
                78****************99999985 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0017
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 +n P ++ v+++ +iy++D+ n  +
  EFC36736.1 170 LNTPDSIYVNQQEEIYICDTLNAKI 194
                 68899**************866655 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 7.5e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +++P+Gv vd + +++y+aD+++  +++
  EFC36736.1 223 LAMPQGVYVDeKKNEVYIADTNSYLIRK 250
                 679*******************988875 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 5.9
                 EEEEEEETTTEEE CS
         NHL   4 PhGvavdsnGdiy 16 
                 P+ v ++s+G+++
  EFC36736.1 283 PRRVKLNSQGEVF 295
                 888999****985 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.1
                 BSSEEEEEEE.TTTEEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaD 19 
                 f  P++v ++ ++  iy+ +
  EFC36736.1 336 FMLPQDVYISkDDQFIYIGE 355
                 678*******8888888877 PP

  == domain 6  score: -3.6 bits;  conditional E-value: 6.8
                 ETTTEEEEEE CS
         NHL  10 dsnGdiyVaD 19 
                 ++  diy+ D
  EFC36736.1 420 NNHQDIYIGD 429
                 6678999998 PP

  == domain 7  score: 0.7 bits;  conditional E-value: 0.28
                 SEEEEEEETTTEEE CS
         NHL   3 yPhGvavdsnGdiy 16 
                  P+G+ vd++G+iy
  EFC36736.1 463 VPRGLFVDDSGNIY 476
                 69**********98 PP

  == domain 8  score: 13.9 bits;  conditional E-value: 1.8e-05
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                 s+Gdiy+aD++n r+++
  EFC36736.1 585 STGDIYIADTGNGRIRK 601
                 78*************87 PP

  == domain 9  score: 18.1 bits;  conditional E-value: 8.6e-07
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                  +P++v+v++ G+i+++D+ n r+++
  EFC36736.1 648 KSPTSVVVNDEGEIFISDRDNYRIFK 673
                 57*********************986 PP

  == domain 10  score: 4.3 bits;  conditional E-value: 0.02
                 EEEEEEETTTEEEEEEC CS
         NHL   4 PhGvavdsnGdiyVaDs 20 
                 P+  +++ +Gd+++aD+
  EFC36736.1 707 PETMTINADGDLFIADN 723
                 88899***********6 PP

  == domain 11  score: -2.8 bits;  conditional E-value: 3.7
                 EEETTTEEEE CS
         NHL   8 avdsnGdiyV 17 
                 av+s++ i+V
  EFC36736.1 827 AVCSQNGICV 836
                 6788888887 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.6       2.8   6.3e+03      23      31 ..      59      67 ..      58      67 .. 0.86
   2 !   16.9   9.9   2.7e-06     0.006       4      32 .]     744     771 ..     741     771 .. 0.91
   3 !   14.2   5.8   1.9e-05     0.042       7      32 .]     786     813 ..     780     813 .. 0.87
   4 !   16.3   5.6   4.3e-06    0.0095       5      32 .]     826     853 ..     822     853 .. 0.86
   5 !   14.8  10.0   1.2e-05     0.027       5      32 .]     867     893 ..     863     893 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.8
       EGF_2 23 CdsgyqGkt 31
                C +gy+G+t
  EFC36736.1 59 CGDGYYGNT 67
                899****86 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 2.7e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+ghG+C ++   C+C+ gy+G +C
  EFC36736.1 744 NSSVCSGHGQCYDFD-MCECQHGYSGVNC 771
                 5789*******9999.9**********99 PP

  == domain 3  score: 14.2 bits;  conditional E-value: 1.9e-05
       EGF_2   7 iCgg.hGtCvnqcGqCdC..dsgyqGktC 32 
                  Cgg hG+C++    C+C  d+ y+G+ C
  EFC36736.1 786 VCGGgHGKCIDVD-TCKCfnDTMYTGPEC 813
                 69999****8666.7************** PP

  == domain 4  score: 16.3 bits;  conditional E-value: 4.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 +  C+++G+Cv+ + +C+C +  y+G +C
  EFC36736.1 826 NAVCSQNGICVDYN-KCQCsNVMYSGLDC 853
                 678*******9555.9***999999*999 PP

  == domain 5  score: 14.8 bits;  conditional E-value: 1.2e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g+G C  ++G C+C++ + G +C
  EFC36736.1 867 SKVCSGNGNCQ-LNGTCSCQPTFVGQQC 893
                 568*******8.79************** PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.029        66     185     224 ..      72     111 ..      51     119 .. 0.83
   2 !    8.6   0.2   0.00056       1.3      91     164 ..     176     254 ..     129     316 .. 0.64
   3 !    6.9   0.1    0.0018       4.1     147     213 ..     424     491 ..     419     497 .. 0.79
   4 ?    1.5   0.0     0.084   1.9e+02     188     220 ..     580     612 ..     529     620 .. 0.69
   5 ?    1.2   0.0       0.1   2.3e+02     193     220 ..     585     612 ..     576     722 .. 0.70

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.029
         SGL 185 epDGlavDaeGnvwvAvwgggkvvrfdpdGklieeiklpa 224
                  p G+ v+++G +++A + +++++++++ G + + +k+p 
  EFC36736.1  72 SPSGIHVTSDGTMYIAEYTSKRIRKVSKIGIVSTLMKTPY 111
                 58899********************999999888888884 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00056
         SGL  91 gvvdpdGrlwfGtmgdeeakgeevgalyrldpdgklervldd.....ltipNGlawspdgktlYlaDsltrkiwaydvd 164
                 + v ++ ++++ +  + + k+ ++g++y + ++gkl+ + +      l++p G+ +++ ++ +Y+aD+    i ++d +
  EFC36736.1 176 IYVNQQEEIYICDTLNAKIKKVSNGKIYTIAGNGKLVNTGNLatqifLAMPQGVYVDEKKNEVYIADTNSYLIRKIDSN 254
                 4555666666666666666666667777777776644443321113345677777777777777777766666666643 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0018
         SGL 147 tlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge...gepDGlavDaeGnvwvAvwgggkvvrfdpd 213
                  +Y+ D   + + ++ ++  + +l   ++f+d   g+   ++p Gl+vD +Gn++ Av+  + v ++d  
  EFC36736.1 424 DIYIGDVQGGLLRKIYYSIGDRQLY--TKFIDYIGGNlmvNVPRGLFVDDSGNIYYAVVFYNNVYKMDVT 491
                 5678888888888888888777555..678898888888888****************988888777755 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.084
         SGL 188 GlavDaeGnvwvAvwgggkvvrfdpdGklieei 220
                 G+   ++G +++A  g+g++++++ + + i+++
  EFC36736.1 580 GFYHRSTGDIYIADTGNGRIRKISANDSTITTV 612
                 344445899999999999999999998877765 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.1
         SGL 193 aeGnvwvAvwgggkvvrfdpdGklieei 220
                 ++G +++A  g+g++++++ + + i+++
  EFC36736.1 585 STGDIYIADTGNGRIRKISANDSTITTV 612
                 4566666666666666666665555443 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.1      0.06   1.4e+02      52      79 ..      69      95 ..      65     100 .. 0.84
   2 ?   -3.0   0.0       3.8   8.6e+03      63      78 ..     179     194 ..     170     199 .. 0.72
   3 ?    3.9   0.0     0.027        61      53      73 ..     223     243 ..     208     251 .. 0.86
   4 !    8.2   0.0    0.0013       2.9      41      74 ..     324     357 ..     319     366 .. 0.90
   5 ?   -1.1   0.1      0.97   2.2e+03      55      84 ..     463     491 ..     454     492 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.06
  Arylesterase 52 glssanGInidadkkyiyvadilresih 79
                   ++s+ GI + +d   +y+a+ + + i 
    EFC36736.1 69 CVNSPSGIHVTSDG-TMYIAEYTSKRIR 95
                  5789******9997.68******99985 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 3.8
  Arylesterase  63 adkkyiyvadilresi 78 
                    ++  iy+ d l+ +i
    EFC36736.1 179 NQQEEIYICDTLNAKI 194
                   4566799999998887 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.027
  Arylesterase  53 lssanGInidadkkyiyvadi 73 
                   l ++ G+ +d +k  +y+ad 
    EFC36736.1 223 LAMPQGVYVDEKKNEVYIADT 243
                   5789***************96 PP

  == domain 4  score: 8.2 bits;  conditional E-value: 0.0013
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadil 74 
                   y++++++   s++  +  + i+ d+++iy+++  
    EFC36736.1 324 YNGDNMNALTSSFMLPQDVYISKDDQFIYIGEFC 357
                   88999999***********************976 PP

  == domain 5  score: -1.1 bits;  conditional E-value: 0.97
  Arylesterase  55 sanGInidadkkyiyvadilresihvmkkh 84 
                    + G+ +d     iy a +  ++++ m++ 
    EFC36736.1 463 VPRGLFVDDS-GNIYYAVVFYNNVYKMDVT 491
                   5677777644.4689999999****99885 PP

>> DUF3997  Protein of unknown function (DUF3997)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.8   4.2e-06    0.0093      15      83 ..     175     245 ..     168     253 .. 0.78
   2 ?   -3.2   0.0       4.4     1e+04      59      78 ..     334     353 ..     313     353 .. 0.65

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.2e-06
     DUF3997  15 vilsqqeasdatqtpiipAkvvkvgydndyiiakqaekralenn...ksislpedsyveedseeYyIidvkn 83 
                  i+ +q++++   +  + Ak+ kv++   y ia  ++  ++ n    +++ +p+  yv+e+++e yI d++ 
  EFC36736.1 175 SIYVNQQEEIYICD-TLNAKIKKVSNGKIYTIAGNGKLVNTGNLatqIFLAMPQGVYVDEKKNEVYIADTNS 245
                 56666666655544.789***************96554433332345**********************985 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 4.4
     DUF3997  59 ksislpedsyveedseeYyI 78 
                  s  lp+d y+ +d +  yI
  EFC36736.1 334 SSFMLPQDVYISKDDQFIYI 353
                 46778999888888765555 PP

>> Virul_fac_BrkB  Virulence factor BrkB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.035        79     110     138 ..      15      43 ..       7      58 .. 0.82
   2 !   11.8   0.2   6.2e-05      0.14       9      34 ..    1017    1042 ..    1014    1067 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.035
  Virul_fac_BrkB 110 rkrllsllllllllvllllslvlsvflqs 138
                     r+r ls+ ++++l +ll+++++l+++ + 
      EFC36736.1  15 RRRKLSWPIIVILSLLLVIATMLISLSNG 43 
                     78999******999999999999887765 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 6.2e-05
  Virul_fac_BrkB    9 AaalayytllSlfPlllvllavlgll 34  
                      +  lay ++lSl+Plll+l+ +++++
      EFC36736.1 1017 SNNLAYLAFLSLIPLLLLLIIIIAIV 1042
                      6789****************999863 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.087   1.9e+02      15      29 ..     226     241 ..     225     248 .. 0.88
   2 ?    9.3   0.3    0.0005       1.1       5      29 ..     454     478 ..     450     478 .. 0.80
   3 ?   -3.6   0.4       5.3   1.2e+04      23      32 ..     586     595 ..     585     597 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.087
        SBBP  15 gngIavDsnGN.iYvt 29 
                 ++g++vD+  N +Y++
  EFC36736.1 226 PQGVYVDEKKNeVYIA 241
                 79************97 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.0005
        SBBP   5 qlGgpgastygngIavDsnGNiYvt 29 
                 ++Gg+     ++g+ vD++GNiY +
  EFC36736.1 454 YIGGNLMVNVPRGLFVDDSGNIYYA 478
                 77777774489************75 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 5.3
        SBBP  23 nGNiYvtGsT 32 
                  G iY++ + 
  EFC36736.1 586 TGDIYIADTG 595
                 6999998555 PP

>> SHP  Small hydrophobic protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   1.2      0.13     3e+02      24      42 ..      23      41 ..      18      50 .. 0.67
   2 ?   10.9   0.8   0.00015      0.33      16      53 ..    1021    1058 ..    1010    1071 .] 0.81

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.13
         SHP 24 iltlislliiitimiailn 42
                i+ ++sll++i+ m+  l 
  EFC36736.1 23 IIVILSLLLVIATMLISLS 41
                6677788777766655444 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00015
         SHP   16 pyftlihmiltlislliiitimiailnklsehktfcnn 53  
                   y++++ +i  l+ l+iii+i++ il     hk + n 
  EFC36736.1 1021 AYLAFLSLIPLLLLLIIIIAIVVKILSGKYSHKNLSNG 1058
                  67788888888888899999999999988889998884 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1071 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       976  (0.0544369); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.61u 0.27s 00:00:00.88 Elapsed: 00:00:00.45
# Mc/sec: 7210.07
//
Query:       EFC36737.1  [L=254]
Description: hypothetical protein NAEGRDRAFT_82132 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.026   14.4   4.8      0.064   13.1   4.8    1.7  1  AT_hook        AT hook motif
      0.076   13.1   0.1        0.4   10.8   0.0    2.1  2  Abhydrolase_4  TAP-like protein


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   4.8   7.2e-06     0.064       1      12 [.      42      53 ..      42      54 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 7.2e-06
     AT_hook  1 kRkRGRPrKaat 12
                +RkRGRP+K+++
  EFC36737.1 42 PRKRGRPAKNPN 53
                7*********97 PP

>> Abhydrolase_4  TAP-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.32   2.9e+03       9      39 ..     106     141 ..      99     145 .. 0.54
   2 ?   10.8   0.0   4.5e-05       0.4      64     100 ..     186     223 ..     174     225 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.32
  Abhydrolase_4   9 aesllsCagwpvspqrprdestakg.....aapvLl 39 
                    ++sllsC+  p    +   ++   +     a+pvLl
     EFC36737.1 106 NNSLLSCSYLPSVVSATLSSKVSSTthiipAVPVLL 141
                    456677999986444443333332223454455555 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 4.5e-05
  Abhydrolase_4  64 vlvtvegeGHgala.agntCvdkavdaYLltGelpadd 100
                    + v ++++ H  ++ ++++Cv+++++++++t ++p++ 
     EFC36737.1 186 KYVNKRQSSHSPISsTSSNCVSNTTQDFIETLSIPTTS 223
                    7788999999999989******************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       970  (0.0541023); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1544.59
//
Query:       EFC36738.1  [L=507]
Description: hypothetical protein NAEGRDRAFT_59927 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.6e-09   36.3   1.2      2e-08   34.5   0.4    2.2  2  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   0.4   1.1e-12     2e-08       2     116 ..      13     175 ..      12     177 .. 0.93
   2 ?   -1.0   0.0      0.11     2e+03      48      82 ..     360     396 ..     347     423 .. 0.61

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 1.1e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS........................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka........................keqeelkkkakeIyneylapsspkelnidkklreel 76 
                 +e++++ +  r+ F eFl+ ++++e l F+   +++k                          k+   l++ ak+I+++y+  + pk ln+++ + +++
  EFC36738.1  13 FEEVMKAPEARENFIEFLRFQHNDEPLLFLNSLDHYKLDyhktkdnllvvsnggverkenecvKKVLHLVSVAKQIISTYF-GNGPKGLNLSQVVIDST 110
                 78999***************************************************9888888888888888*********.88899999999988888 PP

                 HHHHCSS.........................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS  77 ekrleke.........................qpsrklfeeaqeevfellekdsypkFlkselyl 116
                  +  e++                          + + lf +++ +v+  l+ d++p++++s   +
  EFC36738.1 111 LNMWENVtnclekvndsnnnhyeyyvmlmidyLEPHALFGKVEYQVMLDLSYDQFPRYVRSATLH 175
                 88888888888888*****************99999*************************8766 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.11
                 HHHHHHHHHHTS..TTSTTSSTS-HHHHHHHHHHHCS CS
         RGS  48 kkakeIyneyla..psspkelnidkklreelekrlek 82 
                  ++++Iy+e ++  ++  + ++i+++lr++ e+r+  
  EFC36738.1 360 HTMTSIYDESVNcyMNIGHTCKIEEDLRKNKEHRVDA 396
                 4455555543320013345556666666666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       772  (0.0430587); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.29s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2957.21
//
Query:       EFC36739.1  [L=535]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.018   15.1   1.4       0.82    9.8   0.0    3.6  3  DUF962    Protein of unknown function (DUF962)


Domain annotation for each model (and alignments):
>> DUF962  Protein of unknown function (DUF962)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0      0.65   1.2e+04      24      39 ..       3      18 ..       2      37 .. 0.67
   2 ?    9.8   0.0   4.6e-05      0.82      15      68 ..     207     353 ..     204     422 .. 0.83
   3 ?    1.5   0.3     0.018   3.3e+02      20      44 ..     443     493 ..     437     519 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 0.65
      DUF962 24 Hfigvplilltvllll 39
                H +g+ l++l+++l+ 
  EFC36739.1  3 HNLGILLLVLLFCLFT 18
                6777776666555444 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 4.6e-05
      DUF962  15 HsnpinrllHfigvplilltvlllllrak...................................................................... 43 
                 Hs+++  + H+i v+l+++++++ +  +                                                                       
  EFC36739.1 207 HSKRAFYAYHYIVVILAFIVAFVSITVSLipsiiqlrifkvirnlivkfntyvrslwtgseegsmgiekdsdiypeftwfsvkhftlilkvmisltiig 305
                 999999********999999999887777889999**********999999999999999999999999999999999999999999966666666666 PP

      DUF962  44 .......................lklllalfvvgyifafvGHfvfEkr 68 
                                        + +l+++ v+  ++ +v  ++ Ekr
  EFC36739.1 306 yaiaravilgvqdfkrtrliiaiVYYLITVCVFVVTLLWVNLAFSEKR 353
                 666666666666666666666655555556666666666666666665 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.018
      DUF962  20 nrllHfigvplilltvlllllrak..........................l 44 
                 +r + +i +++i+l+++l+l++ +                          +
  EFC36739.1 443 TRFIMLITISFIVLCIFLILISVEniqfntestsfsmgdgslalefiselI 493
                 677888999999999999988877666666666666666665555555541 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (535 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1561  (0.0870656); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.78u 0.33s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 3105.53
//
Query:       EFC36740.1  [L=521]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (521 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1631  (0.0909699); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.83u 0.35s 00:00:01.18 Elapsed: 00:00:00.50
# Mc/sec: 3108.41
//
Query:       EFC36741.1  [L=270]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   14.2   0.2      0.029   13.7   0.2    1.3  1  SUa-2TM   SMODS- and Ubiquitin system-associated 2TM effector


Domain annotation for each model (and alignments):
>> SUa-2TM  SMODS- and Ubiquitin system-associated 2TM effector domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.2   1.6e-06     0.029     161     217 ..      65     123 ..      30     129 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.6e-06
     SUa-2TM 161 kvnqet..selnliledTYpisedkiPetllnlplikvsrsddiegkRyyNeefikeik 217
                 + ++e+  +++nli  + + +++d+i  tl +++    s s   +g    Ne+f+ +++
  EFC36741.1  65 QKEKENclTNINLIQGNSFNVQNDEIDSTLAKIDNCFESDSSILDGTTRTNENFVRNVR 123
                 3344444699*************************************99********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      311  (0.0173462); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1759.78
//
Query:       EFC36742.1  [L=494]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (494 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1122  (0.0625802); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.36s 00:00:01.02 Elapsed: 00:00:00.57
# Mc/sec: 2593.62
//
Query:       EFC36743.1  [L=162]
Description: hypothetical protein NAEGRDRAFT_82136 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0005   20.7   6.1     0.0005   20.7   6.1    2.1  2  Fz        Fz domain
  ------ inclusion threshold ------
       0.08   12.6   2.6      0.065   12.9   1.3    1.3  1  DUF4344   Putative metallopeptidase


Domain annotation for each model (and alignments):
>> Fz  Fz domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   6.2      0.34   3.1e+03      56      93 ..      22      60 ..      11      74 .. 0.66
   2 !   20.7   6.1   5.5e-08    0.0005      36     110 ..      67     135 ..      55     138 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.34
                HHHS---EESSS-EEEE---HH..HHHHHHTT-GGGSTT. CS
          Fz 56 sllfpkCepsgeeeaplppCrs..lCeavrdsCekvlaea 93
                s+ ++ C++         pC s   C  v++sC +v++++
  EFC36743.1 22 SVTAQTCKNA-IVAFDPSPCSSctTCTGVTKSCCSVIQDT 60
                5667778544.33344577765336999999999988544 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 5.5e-08
                 HHHHGGGG-.HHHTTSTTHHHHHHS---EESSS-EEEE---HHHHHHHHTT-GGGSTT....SHHHH---S----. CS
          Fz  36 eefsllvkl.eCspalklflCsllfpkCepsgeeeaplppCrslCeavrdsCekvlaeagfewpeelnceklpeks 110
                 ++++ll  + +C  ++k++ C++   +  +  +++ ++++Crs+C++v+d+C  +     +++    +c+++pe++
  EFC36743.1  67 SALTLLKASeSCVMYMKMYSCAVCDVNNAKYASSSGSITVCRSYCQKVKDACGTSS----TNFK---DCSSYPETN 135
                 33344444489**********99777766777888999**************9966....3344...888888765 PP

>> DUF4344  Putative metallopeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   1.3   7.3e-06     0.065      42      78 ..      86     122 ..      80     139 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 7.3e-06
     DUF4344  42 vfaeCgeanafydpeekeitiCyelveeieelfakan 78 
                 + a C+ +na y+ ++ +it+C ++++++++    ++
  EFC36743.1  86 SCAVCDVNNAKYASSSGSITVCRSYCQKVKDACGTSS 122
                 5677*************************99876655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1375  (0.0766914); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1074.86
//
Query:       EFC36744.1  [L=894]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (894 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       851  (0.047465); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 5244.30
//
Query:       EFC36745.1  [L=771]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   1.7e-106  355.7   1.0   2.8e-106  355.0   1.0    1.3  1  tRNA-synt_1c     tRNA synthetases class I (E and Q), catalyti
      2e-45  154.8   0.1    4.4e-45  153.7   0.1    1.6  1  tRNA-synt_1c_C   tRNA synthetases class I (E and Q), anti-cod
    9.4e-28   97.2   0.1    9.4e-28   97.2   0.1    1.8  2  tRNA_synt_1c_R1  Glutaminyl-tRNA synthetase, non-specific RNA
  ------ inclusion threshold ------
      0.035   14.2   0.6       0.53   10.4   0.0    3.1  4  Med28            Mediator complex subunit 28


Domain annotation for each model (and alignments):
>> tRNA-synt_1c  tRNA synthetases class I (E and Q), catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  355.0   1.0  6.3e-110  2.8e-106       1     311 [.     247     549 ..     247     552 .. 0.97

  Alignments for each domain:
  == domain 1  score: 355.0 bits;  conditional E-value: 6.3e-110
                   S-EEEE---SSSS-BHHHHHHHHHHHHHHHHTT-EEEEEE--SSCCC--HHHHHHHHHHHHHTT---SSEEEEGGGGHHHHHHHHHHHHHTTSEEEE CS
  tRNA-synt_1c   1 kVrtRfaPePtGyLHiGhakaallnylfAknnnGkfilRieDTdperekeeaeesiledlkwlgikwdekptyqsdrfdelkkyaeeLikkGkAYvc 97 
                   k+ tRf+PeP+G+LHiGhaka+ l++++A +++G  +lR++DT+pe+e++ +++si e+++w+g+k+  k+ty+sd++d+++++a++Lik+GkAYv+
    EFC36745.1 247 KIMTRFPPEPNGFLHIGHAKAMNLSFGYAMSEGGCTYLRYDDTNPEKEEKIYFDSIREMMEWMGFKP-FKITYTSDYMDQMYDFAVQLIKEGKAYVD 342
                   689****************************************************************.***************************** PP

                   -STHHHHHHHHCCSSHSS-TTTTS-HHHHHHHHHHHHHTTHSTTTS-EEEESSBTTSS.GGGSSTEEEEEEESGGGSBTTTBTSTSEEE-HHHHHHH CS
  tRNA-synt_1c  98 ectkeeleeereeqeklgskerdrydeenlklfeeemkkgkaegekavvRlkideess.vefrDlvrgriklepqeihdlvivksdiyPtYdfavvi 193
                   + +k e++++re+  k++sk+r+ + eenlk f e+mk g +++++av+R+kid++s+ +++rD v++rik+     h++ ++k++iyPtYdf ++i
    EFC36745.1 343 FSSKKEIHDQREN--KIESKYRNTTPEENLKRF-EQMKMGIYDEGAAVLRVKIDMSSDnYNMRDFVAYRIKYVA---HPHQGNKWCIYPTYDFSHCI 433
                   ***********99..88888*************.9***************************************...******************** PP

                   HHHHTT-SEEEEEGGGGCCHHHHHHHHHHTT-S.-EEEEEE--EEETTSB-SHHHHHHHHHTTSSSSTT-TTSCBHHHHHHCTB-HHHHHHHHHHHC CS
  tRNA-synt_1c 194 dDaleeithvlrteefldntpkyiwllealglevppfiheylrlnlekkklSKRklsllvdekqvkewddlreallnflrrlGwtpekerelftree 290
                   +D+le+ith+l+t ef++++++y+wll  l+l+ +p+++e++rln++  +lSKRk   lv+ek ++ wdd+r  +l +lrr+G+tpe+++++++ ++
    EFC36745.1 434 VDSLENITHSLCTLEFENRRDSYYWLLATLKLY-RPHVYEFSRLNITTALLSKRKVLKLVKEKIIRSWDDPRVLTLAGLRRRGYTPEGIKSFCDDIG 529
                   *********************************.*************************************************************** PP

                   CCSSS.EEEEHHHHHHHHHHH CS
  tRNA-synt_1c 291 liksfdlnresksleafdrkk 311
                   +++   + + +++le   r++
    EFC36745.1 530 VTRVE-NLIPIERLEQSLRTD 549
                   **988.556666666655555 PP

>> tRNA-synt_1c_C  tRNA synthetases class I (E and Q), anti-codon binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.7   0.1   9.7e-49   4.4e-45       2     174 .]     555     746 ..     554     746 .. 0.92

  Alignments for each domain:
  == domain 1  score: 153.7 bits;  conditional E-value: 9.7e-49
  tRNA-synt_1c_C   2 pRymaVldpvkvtienlpegkeeelevplhpknpelgtrkvpfskeiyiereD........akrlkpgeevrLke.lynikveevekdesgevte 87 
                     +R++aVl+p+kv+++n++++k+e++e+++hpk  e+g+r++p+s+ +yie +D        +  l+p++ v L++  +ni++e+v kde+g+++e
      EFC36745.1 555 NRVFAVLEPLKVVLTNYDANKVEHVEAKNHPKLAERGSRQLPLSRVLYIESSDfrevdsedYYGLAPNKSVGLRYaPCNIHCEKVIKDENGKIVE 649
                     8*****************99*******************************************************66****************** PP

  tRNA-synt_1c_C  88 lkleydgesleearkkkgiihWvsa....eeaveaevrlYdrLfkeee.de...dfl..lnpdslkvleeglaepalanlk...kgdivQfeRiG 169
                     l+++ d +++   +k+k+ ihW+s+     ++++aevrlY++Lf+ ++ de   ++l  +np+s+ +  +++++p ++++k   + +++QfeR G
      EFC36745.1 650 LHCTADFDKK---EKPKTYIHWLSQsapgVDPMKAEVRLYEKLFTCDDlDEvgdEWLnyINPNSEIIKPNAFVDPYFQDAKnraVYEKYQFERVG 741
                     ******9655...699*********8888889*************88877788777788******998*******9977762225677******* PP

  tRNA-synt_1c_C 170 yfrvd 174
                     +f+vd
      EFC36745.1 742 FFVVD 746
                     ***98 PP

>> tRNA_synt_1c_R1  Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.2   0.1   2.1e-31   9.4e-28       7     162 .]       7     166 ..       3     166 .. 0.93
   2 ?   -3.0   0.4       1.5   6.5e+03      26      60 ..     176     209 ..     170     220 .. 0.56

  Alignments for each domain:
  == domain 1  score: 97.2 bits;  conditional E-value: 2.1e-31
  tRNA_synt_1c_R1   7 fksiGLsekkaketlknkklsaslkevieeagveek....gldkkkgalLyslatklkkqalekrelivkyIvegklktslqvdaAlkYlskkk 96 
                      + ++GL+ek + +++kn++l++++ + i+e+++  +    +++ + g l+++l+++++++ +++r +i+kyI++gklkt  qv++A+kY++k  
       EFC36745.1   7 LLAVGLNEKDIFNLTKNEALTTKFLRTITEVNIPLEnkssEFNYSCGPLILKLIQSIPDNLADNRLIIAKYIAQGKLKTGVQVEEAIKYAKKIG 100
                      5689**************************887655323456889999********************************************** PP

  tRNA_synt_1c_R1  97 eeeideaefekacGVGvevtpeqieeaVekyieenkeeieekryrknlgkllaevk.klpeLkWAdp 162
                      ++++  ++fe +cGVG  v +e+++e V+  i++nk    +    +n+gkl++ ++ + + Lk+Ad+
       EFC36745.1 101 TTPLPIQDFEVECGVGADVNEEKVTELVNGQISSNKLSYYTIGK-ANVGKLVGTLRnEIKLLKFADG 166
                      ***************************************99877.***********778999***96 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.5
  tRNA_synt_1c_R1  26 lsaslkevieeagveekgldkkkgalLyslatklk 60 
                        ++l+e ++ + vee+  +k ++  ++++at+++
       EFC36745.1 176 AFQALSEELKDTPVEEAP-KKVEKVAVVKTATTTE 209
                      455666666666666643.5555555666665554 PP

>> Med28  Mediator complex subunit 28
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   0.00012      0.53      20     104 ..      13     102 ..       3     135 .. 0.84
   2 ?   -1.5   0.0      0.53   2.4e+03      36      75 ..     146     185 ..     122     196 .. 0.79
   3 ?   -3.5   0.0       2.3     1e+04      52      72 ..     230     250 ..     219     252 .. 0.80
   4 ?   -1.0   0.1      0.39   1.7e+03      15      51 ..     298     340 ..     293     354 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00012
       Med28  20 RekktfvlekrneLsa....svsdlkkelerkaekykvapeellmkHlqktseqlat.qlkalrekgqnvfgdgtkidstidyleklkqv 104
                  ek++f l k+  L +     + ++   le+k+ +++ +   l+ k +q+  ++la  +l   +   q  +  g +++ +i y +k+ ++
  EFC36745.1  13 NEKDIFNLTKNEALTTkflrTITEVNIPLENKSSEFNYSCGPLILKLIQSIPDNLADnRLIIAKYIAQGKLKTGVQVEEAIKYAKKIGTT 102
                 58999***********9999999********************************96257777888999999999999999999987665 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.53
       Med28  36 svsdlkkelerkaekykvapeellmkHlqktseqlatqlk 75 
                 +v  l  +l ++ +  k a  +++++ ++k+ + l+ +lk
  EFC36745.1 146 NVGKLVGTLRNEIKLLKFADGNIIKQVVEKAFQALSEELK 185
                 6667778889999999999999999999998888888776 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 2.3
       Med28  52 kvapeellmkHlqktseqlat 72 
                  v p ell +H ++t  ++ t
  EFC36745.1 230 AVNPPELLEQHKNQTGGKIMT 250
                 5889999**999998877766 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.39
       Med28  15 llDviRekktfvlekrneLsa......svsdlkkelerkaeky 51 
                  +D iRe+  ++  k +++        +++d+  +l ++ + y
  EFC36745.1 298 YFDSIREMMEWMGFKPFKITYtsdymdQMYDFAVQLIKEGKAY 340
                 4799999999999999999878888989999999998886655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (771 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       799  (0.0445647); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 4588.22
//
Query:       EFC36746.1  [L=490]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.7e-13   47.7 160.2    7.7e-13   47.7 160.2    2.0  2  TPH       Trichohyalin-plectin-homology domain


Domain annotation for each model (and alignments):
>> TPH  Trichohyalin-plectin-homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.6  35.7      0.34   6.2e+03     157     242 ..      43     128 ..      33     130 .. 0.85
   2 !   47.7 160.2   4.3e-17   7.7e-13       4     333 ..     130     459 ..     127     473 .. 0.96

  Alignments for each domain:
  == domain 1  score: -4.6 bits;  conditional E-value: 0.34
         TPH 157 ileylkekeereeereaerkekeeekereiarlraqqekaedekaerdelraklaqeeaerkwrqkereeaekkarqreelkeare 242
                 i+ +lk+   +ee++ +++k+ +e+ +r+ +  ++ +  ++ ++++  e r++  +ee++r +r+++  +ae k++q e+l + r 
  EFC36746.1  43 IMNQLKDERDMEEDKNERKKRLKEQSDRRAQNWGNTIDAIRVKQEQEREERNRIKEEEQQRLEREEALYQAEIKRKQIEKLNKMRM 128
                 78888888999999999999999999999999999999999999999999999999999999999999999999999998888775 PP

  == domain 2  score: 47.7 bits;  conditional E-value: 4.3e-17
         TPH   4 neeelrelnskllaakvnkerdaQieekkrikaeekeeerrldemmekerekaleeeeekeeerkekrkeyrqeLeeQieereqkrqeeeeekleEkeq 102
                 ++++++ ++ k+l  +v++er++Qie kk+++++ek+e +   e  +++ +k ++e+ +  ++ kek ke r++ + Qi   +q++++  ee ++Ekeq
  EFC36746.1 130 EDDRVKAVQGKVLLGEVLRERERQIEIKKQMEEMEKQEVESWMEVQREQLQKTAQEKLALSQKAKEKAKEIRKDQDTQIDSIKQRHMKRIEELEKEKEQ 228
                 689**************************************5555555555666********************************************* PP

         TPH 103 ldeivekieeedeaeaeekkekqkelreeldefneeqkerkekekeeekeederileylkekeereeereaerkekeeekereiarlraqqekaedeka 201
                 ++ ++ ++ +e+e+++++k+e+q  + ++ ++  ee +e k++++e eke+ ++ le++ ekee+e e++++++e+ +ek r +++l ++q k+ +e++
  EFC36746.1 229 MRLHLINLSKEEEEKKKKKAEQQLGATAQYKKELEEIEEKKRRQAEYEKEQKLKNLEFIQEKEEKETEQKRREEERMREKLRSRQKLIDKQSKMLEEMK 327
                 *************************************************************************************************** PP

         TPH 202 erdelraklaqeeaerkwrqkereeaekkarqreelkeareeqvelkerrlaeeaereeeefervlrkqaedeekeqeeaekrrekrlehrrelekqie 300
                 ++++ r  + ++e e+k++++e++++++k++ +e + ++r++q+++k+   ++ +e ++ ++++++++ +++  ++   ++  +e+ ++ ++ ++ q  
  EFC36746.1 328 ANEKERYVKQEQEMEEKQKEEEEKQEQRKKAFMETVDNSRKQQMQFKKLVSEKDKEVDKIMAQQARERYKQMAIEDFIDKKNSQERARRVQDYQKLQAT 426
                 *************************************************************************************************** PP

         TPH 301 ereeqreaereeeleegealreeeeerreriee 333
                 e+e++r +e+++ ++e  +++++++++++++ +
  EFC36746.1 427 EKEQKRLEEMKQVRKESIMMEKAKQREEKMLSK 459
                 ***************************999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (490 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5443  (0.303586); expected 358.6 (0.02)
Passed bias filter:                      854  (0.0476323); expected 358.6 (0.02)
Passed Vit filter:                       536  (0.0298957); expected 17.9 (0.001)
Passed Fwd filter:                       143  (0.0079759); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 3.24u 0.45s 00:00:03.69 Elapsed: 00:00:00.87
# Mc/sec: 1702.95
//
Query:       EFC36747.1  [L=944]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.24   12.0   3.8        1.4    9.4   0.1    3.3  3  PH        PH domain


Domain annotation for each model (and alignments):
>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1     8e-05       1.4      60      98 ..     425     465 ..     377     466 .. 0.77
   2 ?    0.7   0.2     0.042   7.5e+02      12      72 ..     633     704 ..     625     735 .. 0.74
   3 ?   -0.1   0.0     0.074   1.3e+03      60      77 ..     786     809 ..     756     835 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 8e-05
                 C...TTSSSSTSEEEEEESTSSSTEEEEEEESSHHHHHHHHH CS
          PH  60 a...tedpkrkfcfelriverngsrtyllqasseeerkeWik 98 
                 +    e  kr+f+f+l ++++++ ++++++++++++   W++
  EFC36747.1 425 EkkgIEALKRDFSFSLHHYKNGS-TELVFCVADKQHSPIWVQ 465
                 13368899********8886665.****************97 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.042
                 SSSSC.SEEEEEEEEETTEEEEESSTTCTTESSEEEEEESTTEEEEEEEC...........TTSSSSTSEEEE CS
          PH  12 sgkkk.swkkrwfvLkdsellyykndksekdkepkgsislsncevvevva...........tedpkrkfcfel 72 
                 ++++k  +k+  +++++ +++ + +  +++++++ +s+  + +++ +++             ++ k ++ f++
  EFC36747.1 633 KQNGKiDFKENQCYVFELCIVSHNQT-RSEQEKLLKSLKFQPVQYDQTKLflhgsysfmnsGNSIKSENIFAI 704
                 33444488999999998888888888.8899999999999999998877688888777776667777777777 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.074
                 C......TTSSSSTSEEEEEESTS CS
          PH  60 a......tedpkrkfcfelriver 77 
                 +      +++++++fcf l   ++
  EFC36747.1 786 NinfhtnNANSNKRFCFDLLRINE 809
                 344555455999*****9943333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (944 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       883  (0.0492498); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.29s 00:00:00.99 Elapsed: 00:00:00.48
# Mc/sec: 5875.49
//
Query:       EFC36748.1  [L=1109]
Description: FH2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.5e-76  255.5  17.2    8.5e-76  255.5  17.2    2.9  5  FH2           Formin Homology 2 Domain
    2.3e-18   66.4   1.0    2.3e-18   66.4   1.0    3.1  4  Drf_GBD       Diaphanous GTPase-binding Domain
    1.1e-14   54.5   0.8    1.1e-14   54.5   0.8    3.6  2  Drf_FH3       Diaphanous FH3 Domain
     0.0071   17.0   0.0        3.7    8.2   0.0    3.9  2  DUF3800       Protein of unknown function (DUF3800)
  ------ inclusion threshold ------
       0.76   10.4   5.2       0.62   10.7   1.6    2.8  3  FOXP-CC       FOXP coiled-coil domain
        1.7    8.9   6.7        6.4    7.1   0.3    3.0  2  WXG100        Proteins of 100 residues with WXG
        2.3    8.1  24.4       0.26   11.2   6.5    3.5  3  CortBP2       Cortactin-binding protein-2
        7.7    6.7   9.0         11    6.1   0.1    3.8  4  DUF2730       Protein of unknown function (DUF2730)
        9.4    6.9   8.4        6.1    7.5   1.2    3.5  2  SlyX          SlyX


Domain annotation for each model (and alignments):
>> FH2  Formin Homology 2 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   2.7         4     8e+03       7      17 ..      99     109 ..       5     126 .. 0.56
   2 ?   -2.1   0.6      0.79   1.6e+03       7      35 ..      99     127 ..      93     165 .. 0.78
   3 ?   -3.4   0.1       2.1   4.1e+03      70      99 ..     384     414 ..     351     427 .. 0.64
   4 ?   -1.0   0.2      0.38   7.6e+02     279     327 ..     481     508 ..     454     526 .. 0.59
   5 !  255.5  17.2   4.3e-79   8.5e-76       4     372 .]     654    1030 ..     651    1030 .. 0.95

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 4
                 -SS-B------ CS
         FH2   7 pkkkLkplhWd 17 
                  k+k+k ++Wd
  EFC36748.1  99 SKHKTKEMKWD 109
                 34444444444 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.79
                 -SS-B------EESSGGCTTSCCCCTCCH CS
         FH2   7 pkkkLkplhWdkvkpsqdrstvWdklkee 35 
                  k+k+k ++Wd v++  ++++ +++ +++
  EFC36748.1  99 SKHKTKEMKWDFVQSLRKNQDTFSSDERN 127
                 6899*******999888887766655554 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 2.1
                 CTTCCESSS-HHHHHHHHHHHHHH.TS-HHH CS
         FH2  70 kkkkkvklLdpkrsqniaIlLkkl.kltaee 99 
                 + ++  ++ d++ s+ ++I+L +l +++ + 
  EFC36748.1 384 RFEQFKTIVDSNPSELTEIILGQLsEISQKY 414
                 4455566666666666666666664444443 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.38
                 HHHHHHHHHHHHHHHHHHHHHHHCCTTSSTT-THHHHHHHHHHHHHHHH CS
         FH2 279 eslekevkklekglkklekelessekkeepsdkflevlkeflkeaeekl 327
                 e l+++vk+ ++++ ++e++l+++++                     kl
  EFC36748.1 481 ERLKQQVKTQQTQFTNMEQKLKAEKE---------------------KL 508
                 33333333333333333333333333.....................22 PP

  == domain 5  score: 255.5 bits;  conditional E-value: 4.3e-79
                  X---SS-B------EESSGGCTTSCCCCTCCHHHHC..TSHHHHHHHHTBSC--HCCH......HCSCCTTCCESSS-HHHHHHHHHHHHHHTS-HH CS
         FH2    4 kikpkkkLkplhWdkvkpsqdrstvWdklkeesfek..eldlseleelFsakekkkkkkksekskkskkkkkkvklLdpkrsqniaIlLkklkltae 98  
                  +++p+  L+ +h d +++  +++t++ k    +  k  +ld +++eelF +++++ +k +   +++ k++++k++++d+krs ni+I L +++l+++
  EFC36748.1  654 TYNPSANLRNVHIDPINKRVVKDTIFIKKGVIERLKqiQLDEKRIEELFTIEKDQHNKPS---QQSDKQSNEKISFIDAKRSYNIGIQLASMRLPVD 747 
                  67888999999999999999999988664433333334999999********99766665...9999****************************** PP

                  HHHHHHHTTTTCCCTHHHHHHHHHHCGGHHHHHHHHCTCTSGTTB-HHHHHHHHHTTSTTHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHHHH CS
         FH2   99 eiveaileldeealdlellenLlkmaPtkeelkklkeykgevseLseaeqFllelvkiprlekRleallfkstfeeeveelkrslealeaaseeLkn 195 
                   i++ i++lde++l++++++ L  ++Ptkee +++++++g++s+Ls+++ F++ + +++ +++R++a++fk  +e++++ lk+++e+l+ a+ eLk+
  EFC36748.1  748 TIKQGIIALDEKVLNKNQINILKSIVPTKEECDAYASFEGSISQLSDPDCFFYKVKDVSKVKERMDAWTFKLRYEDDLSTLKPDIECLRLATIELKE 844 
                  ************************************************************************************************* PP

                  -HHHHHHHHHHHHHHHHHSTCSTTCS-SEE-GGGGGGCCCSB-S.TTTSBHHHHHHHHHHTTSGGGGGHHHHTTTHHHCCTS-HHHHHHHHHHHHHH CS
         FH2  196 skkfkklLeliLalGNymNdgtrrgqAkGFkLssLlkLsdvKst.dnkttLLHylvkiireklpevldfsseLknvkkaakvnleslekevkklekg 291 
                  skkf k+L ++L + Ny+N+  r+++ +GF LssL k++d+Ks+ +   +LLHylv++i+++ ++++ f+++L nv++a k ++ ++++++++++++
  EFC36748.1  845 SKKFVKFLAVVLSIANYLNAKGRQKDQYGFHLSSLHKMKDTKSKsSDGFSLLHYLVEYIDNNQKDLSMFYDDLPNVPSAKKASISQIKESLQNIRSS 941 
                  ********************************************8999************************************************* PP

                  HHHHHHHHHHCCT......TSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT--TT..CCHHHHHHHHHHHHHHHHH CS
         FH2  292 lkklekelessek......keepsdkflevlkeflkeaeeklkkleeelkeakelvkelveYfgedkk..evspeeffkilreFlkefk 372 
                    +l   le+ ek      + +++d+f+e++k+f ++++++l+ lee+lk+++e ++e++  f+edk+  + +pe ff +l+eF ++fk
  EFC36748.1  942 SNALGNVLEALEKerheadQINKQDQFIEKMKPFYEQTKTDLAMLEEKLKKTLEGLEEIAILFDEDKTmvTNKPEDFFTKLDEFFEMFK 1030
                  ****99999999988888888899********************************************999****************97 PP

>> Drf_GBD  Diaphanous GTPase-binding Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.5   1.7       6.5   1.3e+04      23      39 ..       8      24 ..       1      53 [. 0.40
   2 !   66.4   1.0   1.2e-21   2.3e-18       5     161 ..      72     257 ..      68     260 .. 0.92
   3 ?   -3.8   0.3       4.1   8.1e+03      36      63 ..     707     720 ..     685     736 .. 0.44
   4 ?   -3.6   2.4       3.5     7e+03      53      96 ..    1007    1057 ..     950    1062 .. 0.54

  Alignments for each domain:
  == domain 1  score: -4.5 bits;  conditional E-value: 6.5
     Drf_GBD 23 peekreallalpiekKw 39
                ++++ +++++++ +kK 
  EFC36748.1  8 EQQQPQQNRKKSSMKKF 24
                33444444444444432 PP

  == domain 2  score: 66.4 bits;  conditional E-value: 1.2e-21
     Drf_GBD   5 deeeidklFeelleelnlpeekreallalp..iekKwqlvvqdkkkkakkeeklsksksksneeespesyvkklkddslke.................k 84 
                 deeei+  F+e +e++ +++e+++  +++    e Kw +v++ +k ++            s+e +++ +y+++l++ ++                   k
  EFC36748.1  72 DEEEINRRFMEAVEQIGIQNEAKQMFISKHktKEMKWDFVQSLRKNQDTFS---------SDERNKVDYYIHCLQKSASVVgpsmekinsdksieemiK 161
                 89*********************999876511677******9999777666.........899999*********9999999***************** PP

     Drf_GBD  85 qlesLrVaLrtqplsWvkrFieleGlvaLlnvLskinekkaee...................eedlkkeyeiikClKalmNnkvGldavlahksvi 161
                 ++++L V+Lr+qp++W+++Fi  +Gl  L+ +L +  +  +                     ++  +  ++i+ ++  l+N   G+++ l++ ++i
  EFC36748.1 162 IVQKLTVQLRSQPITWLEEFIRQGGLYQLTCLLACTINFFSLFgnyststdnggngvhqtslNNVEQLRTSILMSFTSLLNVDAGIKSFLSQRDSI 257
                 ***********************************999888888899999***********999999*************************9998 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 4.1
     Drf_GBD  36 ekKwqlvvqdkkkkakkeeklsksksks 63 
                 ++  +                ++s+++s
  EFC36748.1 707 DQHNK--------------PSQQSDKQS 720
                 22111..............112222222 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 3.5
     Drf_GBD   53 e.........eklsksksksneeespesyvkklkddslkekqlesLrVaLrtq 96  
                  +         ++ +k ++  + ++s+  y++++k+++ +   + + +V+L+ +
  EFC36748.1 1007 DktmvtnkpeDFFTKLDEFFEMFKSARKYIQERKKKEEE--AMRKKSVQLNAN 1057
                  133344344455566666667777777777777766544..555556666555 PP

>> Drf_FH3  Diaphanous FH3 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.5   0.8   5.7e-18   1.1e-14       3     157 ..     263     432 ..     261     469 .. 0.85
   2 ?   -5.6   8.3         9   1.8e+04      73     191 ..     931    1055 ..     922    1059 .. 0.63

  Alignments for each domain:
  == domain 1  score: 54.5 bits;  conditional E-value: 5.7e-18
                 HHHHHHHHHHHHHCCT-SSTTHHHHHHHHH....................HSS-HHHHHHHHHHHHHHHHSSSSHHHHHHHHHHHHCTTHHHHHHHHCT CS
     Drf_FH3   3 hekvleatldfkevaeergrfrslvgaldel...................enelveykvatmllInalvnspedlqfRlhLRseflalGLdkiidklre 82 
                  e++l+a+ ++k v++e++rf++l + + +                     ++  e+ v  + +In+l ++p+d ++R ++++ef++l L++++d +  
  EFC36748.1 263 FELILDAMNHYKLVKREKKRFQNLAEWILSEnsyasgttatgimytggghGRACTEFRVNALMFINTLMTTPDDPKMRSRIQQEFINLDLERVLDTIDS 361
                 5899**********************9887788*****************99********************************************987 PP

                 SCSHHHHHHHHHHHHHHHHHHHHHHHHHT.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXX CS
     Drf_FH3  83 leneeLddqlqafeeerneDeeellerae.dktvdlddpeelfellknkvkdteaepyllsilqhlllirddeeek 157
                   +++L+ q++ f++e n   +e  +r+e  kt+  ++p+el e +  ++++ + ++y++ +l  +l i +++e+ 
  EFC36748.1 362 A-DPDLQIQINTFKDEIN---QENVNRFEqFKTIVDSNPSELTEIILGQLSEIS-QKYFTKMLNSFLSIAQSYEDT 432
                 7.9***************...666666664566666778889888888887764.678888888888884444333 PP

  == domain 2  score: -5.6 bits;  conditional E-value: 9
                  HHHHHHHHCTSCSHHHHHHHHHHHHHH.HHHHHHHHHHHT.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXX CS
     Drf_FH3   73 LdkiidklreleneeLddqlqafeeer.neDeeellerae.....dktvdlddpeelfellknkvkdteaepyllsilqhllli..rddeeekesyl 161 
                  +++ ++++r + +  L + l+a e+er ++D    ++++        +   +d   l e+lk+++++ e+  +l ++ + + ++  +d  +++ +++
  EFC36748.1  931 IKESLQNIRSS-SNALGNVLEALEKERhEADQINKQDQFIekmkpFYEQTKTDLAMLEEKLKKTLEGLEEIAILFDEDKTMVTNkpEDFFTKLDEFF 1026
                  44445555544.7789999999987751455544444443533343333334555677778888888888888888888888887666677888888 PP

                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
     Drf_FH3  162 klleelvsqivlqrtkidpkkderksleva 191 
                  +++ ++ ++i+  ++k ++++ ++ks++++
  EFC36748.1 1027 EMFKSARKYIQERKKK-EEEAMRKKSVQLN 1055
                  8888888888877665.4445566666665 PP

>> DUF3800  Protein of unknown function (DUF3800)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0    0.0018       3.7      18     110 ..     452     740 ..      20     742 .. 0.86
   2 ?   -1.4   5.1       1.7   3.4e+03      36      85 ..     934    1014 ..     798    1059 .. 0.63

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0018
     DUF3800  18 pyfvlgg............................kkie..eikkleekikelkkky.......................................... 44 
                 ++ vl+g                            +k +  + +++e+k+k+ k+k+                                          
  EFC36748.1 452 NWHVLAGlvqqivdsvdqkgrlrnwgeeterlkqqVKTQqtQFTNMEQKLKAEKEKLakalneggsidvndfellkdivtsvttktvsgsssspslpvp 550
                 566666666666655555555555555554444332222344444444444444444777777777777777777788888888888888888888888 PP

     DUF3800  45 ................................................................................................... 44 
                                                                                                                    
  EFC36748.1 551 tgkplptipgkpvettieqpveqaivvpsvmvppppigtgsvppppgtmvpppppgvgvppppgtgipmppgvgvppppgsgmmppppgmlggvaqpal 649
                 888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888 PP

     DUF3800  45 ................................krlleriakflkkndliksdeesdesilivldkkkkkekakkel.eilldesvkfvdSk..esrglQ 108
                                                 k ++er+++  ++      +++ +e + i+ d+++k +++ ++  +    e++ f d k   ++g+Q
  EFC36748.1 650 palptynpsanlrnvhidpinkrvvkdtifikKGVIERLKQIQLD------EKRIEELFTIEKDQHNKPSQQSDKQsN----EKISFIDAKrsYNIGIQ 738
                 888888888888866666666555666655555555555444433......455566666666665554444433344....88999888844567799 PP

     DUF3800 109 lA 110
                 lA
  EFC36748.1 739 LA 740
                 98 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.7
     DUF3800   36 kikelkkky..............................krlleriakflkkn.....dlik.....sdeesdesilivldkkkkkekak 85  
                          +                              ++++e+++ f+++      +        +  e+ e+i i++d++k++ + k
  EFC36748.1  934 S-------LqnirsssnalgnvlealekerheadqinkqDQFIEKMKPFYEQTktdlaM--LeeklkKTLEGLEEIAILFDEDKTMVTNK 1014
                  2.......133333335555555555555555555555566666666666553343331..03355566667777777777755554433 PP

>> FOXP-CC  FOXP coiled-coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   1.6   0.00031      0.62      28      62 ..     475     509 ..     462     513 .. 0.87
   2 ?   -2.1   0.0       3.1   6.2e+03      35      58 ..     933     956 ..     907     964 .. 0.56
   3 ?   -3.1   0.0       6.7   1.3e+04      37      53 ..     959     975 ..     937     990 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00031
     FOXP-CC  28 seHalddkstaqlrvqmqvvqqlekqlvkEkerLq 62 
                 +  + +++   q++ q+    ++e++l++Eke+L 
  EFC36748.1 475 NWGEETERLKQQVKTQQTQFTNMEQKLKAEKEKLA 509
                 5566789999***********************97 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 3.1
     FOXP-CC  35 kstaqlrvqmqvvqqlekqlvkEk 58 
                 +s+  +r  ++ + ++ + l kE+
  EFC36748.1 933 ESLQNIRSSSNALGNVLEALEKER 956
                 344444444444445555555554 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 6.7
     FOXP-CC  37 taqlrvqmqvvqqlekq 53 
                 + q++ q q +++++  
  EFC36748.1 959 ADQINKQDQFIEKMKPF 975
                 34666666666666554 PP

>> WXG100  Proteins of 100 residues with WXG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   1.6     0.053   1.1e+02      52      83 ..     479     510 ..     476     512 .. 0.70
   2 ?    7.1   0.3    0.0032       6.4      11      82 ..     926     998 ..     921    1000 .. 0.91

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.053
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      WXG100  52 efeewkqaaqklvdaLeeisealkqaanafed 83 
                 e e++kq++++ ++++++++++lk+ ++++++
  EFC36748.1 479 ETERLKQQVKTQQTQFTNMEQKLKAEKEKLAK 510
                 45677777777777777777777777777665 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0032
                 HHHHHHHHHHHHHHHHHHHHHHHHHHC.GCGCTHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      WXG100  11 qaaarfqkqaeeledelqrlkaevdal.qsgWsGaaadafqaefeewkqaaqklvdaLeeisealkqaanafe 82 
                 +++++++++ +++++  ++l + ++al ++  + +  ++ ++++e++k+  ++ ++ L+ ++e+lk++ + +e
  EFC36748.1 926 ASISQIKESLQNIRSSSNALGNVLEALeKERHEADQINKQDQFIEKMKPFYEQTKTDLAMLEEKLKKTLEGLE 998
                 67889999999****************999***********************************99876666 PP

>> CortBP2  Cortactin-binding protein-2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   1.9   0.00086       1.7     141     177 ..     478     514 ..     471     521 .. 0.87
   2 ?   -3.4   1.3       3.9   7.7e+03     110     133 ..     694     717 ..     681     724 .. 0.46
   3 ?   11.2   6.5   0.00013      0.26      68     173 ..     947    1056 ..     917    1063 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00086
     CortBP2 141 kererLkqeleqekaqkkklekelkkllekleeerkk 177
                 +e erLkq+++++++q  ++e++lk ++ekl + +++
  EFC36748.1 478 EETERLKQQVKTQQTQFTNMEQKLKAEKEKLAKALNE 514
                 6999********************9999999887765 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 3.9
     CortBP2 110 rhrkvleeLeeekrkheedtaqgd 133
                   +++ e +  ek +h++ ++q+d
  EFC36748.1 694 DEKRIEELFTIEKDQHNKPSQQSD 717
                 333333333334444444444444 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00013
     CortBP2   68 ketsesevkklyekqlaeLekliekqreaqermleqLaaaekrhrkvleeLee.....ekrkheedtaqgddvtylLekererLkqeleqekaqkkk 159 
                  +  ++ e ++++ +q+++ ++ iek +  +e+++  La++e++ +k+le Lee     + + ++  t++ +d+ + L++  e  k+  ++ +++kkk
  EFC36748.1  947 NVLEALEKERHEADQINKQDQFIEKMKPFYEQTKTDLAMLEEKLKKTLEGLEEiailfD-EDKTMVTNKPEDFFTKLDEFFEMFKSARKYIQERKKK 1042
                  4444555666777***************************************9444322.4445579999999999999999999999888888888 PP

     CortBP2  160 lekelkklleklee 173 
                   e+ ++k++ +l+ 
  EFC36748.1 1043 EEEAMRKKSVQLNA 1056
                  88888888877765 PP

>> DUF2730  Protein of unknown function (DUF2730)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.3     0.024        47      33      57 ..     478     502 ..     455     508 .. 0.94
   2 ?   -3.0   0.1       4.1   8.1e+03      27      52 ..     677     701 ..     674     716 .. 0.76
   3 ?   -3.0   0.0       4.1   8.1e+03      41      76 ..     804     836 ..     800     847 .. 0.65
   4 ?    6.1   0.1    0.0058        11      36      91 ..     897     954 ..     880     958 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.024
     DUF2730  33 edleklaekveendkrlteletkve 57 
                 e+ e+l+++v++++++ t++e+k++
  EFC36748.1 478 EETERLKQQVKTQQTQFTNMEQKLK 502
                 6899******************986 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.1
     DUF2730  27 skYakredleklaekveendkrltel 52 
                 + ++k+  +e+l ++++  +kr++el
  EFC36748.1 677 TIFIKKGVIERL-KQIQLDEKRIEEL 701
                 568899999999.7788888888876 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 4.1
     DUF2730  41 kveendkrlteletkvenLPtakdlekLkllladlr 76 
                  v++ ++r+++   k+ +   ++dl++Lk +++ lr
  EFC36748.1 804 DVSKVKERMDAWTFKLRY---EDDLSTLKPDIECLR 836
                 456666777766666554...778888877777666 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0058
     DUF2730  36 eklaekveendkrlteletkvenLPtakd..lekLkllladlrgelkaleaevrqlsh 91 
                 + l+e +++n+k l+     + n+P+ak   ++++k  l+++r  ++al + +++l++
  EFC36748.1 897 HYLVEYIDNNQKDLSMFYDDLPNVPSAKKasISQIKESLQNIRSSSNALGNVLEALEK 954
                 6688999999999*99999******98753389*****************99999987 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   1.2    0.0031       6.1      20      52 ..     481     513 ..     477     522 .. 0.82
   2 ?    1.0   1.0      0.34   6.7e+02      14      51 ..     957     994 ..     947    1007 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0031
                 HHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXX CS
        SlyX  20 eeLndvvaeqqqqidrlqrqlrllaerlkelee 52 
                 e+L ++v  qq q + ++++l++ +e+l+++ +
  EFC36748.1 481 ERLKQQVKTQQTQFTNMEQKLKAEKEKLAKALN 513
                 8999*********************99955444 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.34
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXX CS
        SlyX  14 fqedtieeLndvvaeqqqqidrlqrqlrllaerlkele 51 
                 +  d+i++ ++ + +     ++ ++ l++l+e+lk+  
  EFC36748.1 957 HEADQINKQDQFIEKMKPFYEQTKTDLAMLEEKLKKTL 994
                 56677777777777888888888888888888886544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1991  (0.111049); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.96u 0.33s 00:00:01.29 Elapsed: 00:00:00.53
# Mc/sec: 6355.67
//
Query:       EFC36749.1  [L=307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-11   45.0   2.6    0.00025   21.6   0.1    3.8  4  Ank_2     Ankyrin repeats (3 copies)
    1.5e-08   34.2   3.0      0.023   15.2   0.0    5.9  7  Ank_3     Ankyrin repeat
      6e-05   23.5   0.2       0.97   10.1   0.0    4.6  5  Ank_4     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.025   14.9   0.0        2.3    8.7   0.0    3.0  3  Ank_5     Ankyrin repeats (many copies)
        0.1   13.1   4.8         76    4.0   0.0    5.2  6  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.1    0.0067        24      24      49 ..      43      75 ..       1      83 [. 0.48
   2 !   20.0   0.3   2.1e-07   0.00076       6      83 .]      58     137 ..      53     137 .. 0.71
   3 !   21.6   0.1     7e-08   0.00025       3      80 ..      85     168 ..      83     170 .. 0.70
   4 !   16.5   0.0   2.7e-06    0.0099       8      75 ..     151     247 ..     141     258 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0067
       Ank_2 24 k....ngktaLhyAakngnl.eivklLleh..a 49
                +    ++ t+L +A   ++  +i+ +Lle+  +
  EFC36749.1 43 SldkiEHITPLRIALDDNHSmDIIGILLENskT 75
                022345667777777766655667777665433 PP

  == domain 2  score: 20.0 bits;  conditional E-value: 2.1e-07
       Ank_2   6 kngnl.elvklLl..egadpnkngktaLhyAakngnleivklLleh..ad.ndgrtpLhyAarsghleivklLlek.gadinlkd 83 
                  ++++ +++ +Ll  ++++pn  +       +k+gnle+v+l+l++  +d n+g  pL y+ +++  ei+  +l + + d+n+ d
  EFC36749.1  58 DDNHSmDIIGILLenSKTNPN--ECQSFVQVCKSGNLEMVQLFLNNpnIDiNQG-CPLAYCLENS--EILSRFLTNtNLDLNIED 137
                 445555899999954445554..567777799999*********9977776656.6*****9644..899877744488888765 PP

  == domain 3  score: 21.6 bits;  conditional E-value: 7e-08
       Ank_2   3 lAakngnlelvklLlegadpnkngktaLhyAakngnleiv.klLleh...ad.ndgrtpLhyAars...ghleivklLl.ekgadin 80 
                 + +k+gnle+v+l+l++ +++ n   +L y+ +n   ei+ ++L +    ++ +dg  +L  A++    + +e++  Ll  k+ d+n
  EFC36749.1  85 QVCKSGNLEMVQLFLNNPNIDINQGCPLAYCLENS--EILsRFLTNTnldLNiEDG-LILKSAIKLsnqTKFEVITKLLsRKDLDVN 168
                 6789999********4444443556********98..9983555554755555555.69*****88644357888888833355665 PP

  == domain 4  score: 16.5 bits;  conditional E-value: 2.7e-06
       Ank_2   8 gnlelvklLlegadpnkngktaLhyAakngnleivklLle.....h..................ad......ndgrtpLhyAarsghleivklLlek 75 
                  ++e++  Ll+ +d++ n  ++ +  +++g+leivkl+++     +                  ++      n    p+ ++  ++h+e++++L+e+
  EFC36749.1 151 TKFEVITKLLSRKDLDVNRGFVFYELCSKGDLEIVKLFVNmrkdlKpdllgppikhtgsegfldVEshkqaiNFQFRPIEISYMNNHEELAQYLIEN 247
                 34689999995555553355*******************9776551555555555677677755225555677799*******************86 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.16   5.6e+02      15      30 ..       6      21 ..       1      22 [. 0.80
   2 !    5.6   0.0    0.0085        30       3      30 ..      50      78 ..      48      79 .. 0.89
   3 !   15.2   0.0   6.3e-06     0.023       8      30 ..      85     107 ..      82     108 .. 0.93
   4 ?   -2.7   0.0       4.3   1.5e+04      14      31 .]     118     135 ..     113     135 .. 0.67
   5 ?   -2.2   0.0         3   1.1e+04      14      30 ..     152     168 ..     149     169 .. 0.68
   6 ?    2.9   0.0     0.067   2.4e+02       7      26 ..     174     192 ..     172     196 .. 0.82
   7 ?    3.3   0.0     0.049   1.8e+02      10      24 ..     233     247 ..     226     254 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.16
       Ank_3 15 leivkfLlenkgadvn 30
                  ivk++l+++++d n
  EFC36749.1  6 KHIVKLILKKPNIDTN 21
                458******9999977 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0085
       Ank_3  3 etpLhlAarsgnl.eivkfLlenkgadvn 30
                 tpL +A+  ++  +i+  Llen   ++n
  EFC36749.1 50 ITPLRIALDDNHSmDIIGILLENSKTNPN 78
                69***********77*******9888888 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 6.3e-06
       Ank_3   8 lAarsgnleivkfLlenkgadvn 30 
                 ++++sgnle+v+++l+n+++d+n
  EFC36749.1  85 QVCKSGNLEMVQLFLNNPNIDIN 107
                 79********************9 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 4.3
       Ank_3  14 nleivkfLlenkgadvna 31 
                 n ei+  +l n + d+n+
  EFC36749.1 118 NSEILSRFLTNTNLDLNI 135
                 445677777777888775 PP

  == domain 5  score: -2.2 bits;  conditional E-value: 3
       Ank_3  14 nleivkfLlenkgadvn 30 
                 ++e++  Ll  k  dvn
  EFC36749.1 152 KFEVITKLLSRKDLDVN 168
                 67766666665888887 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.067
       Ank_3   7 hlAarsgnleivkfLlenkg 26 
                 ++ ++ g+leivk++++ + 
  EFC36749.1 174 YELCSKGDLEIVKLFVN-MR 192
                 678***********998.55 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.049
       Ank_3  10 arsgnleivkfLlen 24 
                  ++++ e++++L+en
  EFC36749.1 233 YMNNHEELAQYLIEN 247
                 6889999*******6 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   0.00027      0.97       3      55 .]      51      99 ..      49      99 .. 0.84
   2 !    9.9   0.0    0.0003       1.1       7      28 ..      85     107 ..      81     111 .. 0.88
   3 ?   -1.9   0.0       1.6   5.7e+03      10      29 ..     146     169 ..     140     169 .. 0.67
   4 ?    2.8   0.0     0.053   1.9e+02       8      26 ..     176     194 ..     172     204 .. 0.79
   5 ?    3.0   0.0     0.045   1.6e+02      11      24 ..     235     249 ..     218     262 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00027
       Ank_4  3 taLhyaai.sgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55
                t+L  a      ++++ +Lle+ + ++n++        +  ++k gn+e+++l+l
  EFC36749.1 51 TPLRIALDdNHSMDIIGILLENsKTNPNEC------QSFVQVCKSGNLEMVQLFL 99
                56666666667789999***9879999999......66***************97 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0003
       Ank_4   7 yaaisgrlelvrlLlek.gadin 28 
                 + ++sg+le+v+l l++ ++din
  EFC36749.1  85 QVCKSGNLEMVQLFLNNpNIDIN 107
                 6799***********99999998 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.6
       Ank_4  10 i...sgrlelvrlLlek.gadina 29 
                 +   + ++e++  Ll++ + d+n+
  EFC36749.1 146 KlsnQTKFEVITKLLSRkDLDVNR 169
                 444477788888888764688886 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.053
       Ank_4   8 aaisgrlelvrlLlekgad 26 
                 ++++g+le+v+l ++ ++d
  EFC36749.1 176 LCSKGDLEIVKLFVNMRKD 194
                 6778888888888887777 PP

  == domain 5  score: 3.0 bits;  conditional E-value: 0.045
       Ank_4  11 sgrlelvrlLlek.g 24 
                  +++el+++L+e+ +
  EFC36749.1 235 NNHEELAQYLIENtR 249
                 689999999998745 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0   0.00063       2.3      20      44 ..      83     108 ..      69     111 .. 0.84
   2 ?   -3.3   0.0       3.6   1.3e+04      37      46 ..     128     137 ..     119     146 .. 0.58
   3 ?    2.8   0.0     0.043   1.5e+02       2      38 ..     160     191 ..     159     196 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00063
       Ank_5  20 LhvAakygaadvvrlLl.argadlnl 44 
                 + + +k g++++v+l+l +++ d+n+
  EFC36749.1  83 FVQVCKSGNLEMVQLFLnNPNIDINQ 108
                 67889************999999886 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.6
       Ank_5  37 argadlnltd 46 
                 + ++dln+ d
  EFC36749.1 128 NTNLDLNIED 137
                 4444444444 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.043
       Ank_5   2 lehgpadvnrldgggntpLhvAakygaadvvrlLlar 38 
                 l++ + dvnr       ++   +++g +++v+l++++
  EFC36749.1 160 LSRKDLDVNRG-----FVFYELCSKGDLEIVKLFVNM 191
                 55556666666.....7777789***********943 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.26   9.2e+02      14      31 ..       5      20 ..       2      21 .. 0.68
   2 ?    4.0   0.0     0.021        76       4      28 ..      51      78 ..      49      82 .. 0.78
   3 ?    3.5   0.1      0.03   1.1e+02      11      29 ..      88     104 ..      85     108 .. 0.75
   4 ?   -1.8   0.0       1.4   5.1e+03       8      27 ..     114     131 ..     111     137 .. 0.57
   5 ?    0.6   0.0      0.25   9.1e+02      10      22 ..     177     189 ..     175     199 .. 0.78
   6 ?   -1.0   0.0      0.82     3e+03      11      22 ..     234     245 ..     222     253 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.26
                THHHHHHHHTTTSTTCBT CS
         Ank 14 kkriiklLLhGAnlnald 31
                +k+i+kl+L+   +n+ +
  EFC36749.1  5 SKHIVKLILK--KPNIDT 20
                578***9994..366655 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.021
                BHHHHHH.HHTTHHHHHHHH.TT.TSTT CS
         Ank  4 TPLHlAa.tngkkriiklLL.hG.Anln 28
                TPL +A   n + +ii  LL ++  n+n
  EFC36749.1 51 TPLRIALdDNHSMDIIGILLeNSkTNPN 78
                99999886555588******86557887 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.03
                 HHTTHHHHHHHHTTTSTTC CS
         Ank  11 tngkkriiklLLhGAnlna 29 
                   g++++++l+L   n+n+
  EFC36749.1  88 KSGNLEMVQLFL-N-NPNI 104
                 56899*******.5.5665 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 1.4
                 HHHHHTTHHHHHHHHTTTST CS
         Ank   8 lAatngkkriiklLLhGAnl 27 
                 + +   + +i++ +L   nl
  EFC36749.1 114 Y-C-LENSEILSRFLTNTNL 131
                 4.5.4667899988843343 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.25
                 HHHTTHHHHHHHH CS
         Ank  10 atngkkriiklLL 22 
                 ++ g+++i+kl++
  EFC36749.1 177 CSKGDLEIVKLFV 189
                 557889*****98 PP

  == domain 6  score: -1.0 bits;  conditional E-value: 0.82
                 HHTTHHHHHHHH CS
         Ank  11 tngkkriiklLL 22 
                 +n++++ +++L+
  EFC36749.1 234 MNNHEELAQYLI 245
                 789999***999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       502  (0.0279993); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1835.59
//
Query:       EFC36750.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00062   18.1  12.5    0.00081   17.7  12.5    1.1  1  Nop14           Nop14-like family
    0.00065   19.2   9.5    0.00084   18.9   9.5    1.1  1  SDA1            SDA1
    0.00078   17.9   6.2    0.00095   17.6   6.2    1.1  1  CDC45           CDC45-like protein
     0.0031   17.2   0.2        1.7    8.6   0.0    2.6  2  RCC1_2          Regulator of chromosome condensation (RCC1) r
     0.0034   16.0   5.6     0.0044   15.6   5.6    1.1  1  RRN3            RNA polymerase I specific transcription initi
  ------ inclusion threshold ------
      0.036   13.1   0.3       0.05   12.6   0.3    1.2  1  DUF913          Domain of Unknown Function (DUF913)
      0.059   12.7   7.1       0.13   11.6   7.1    1.6  1  NOA36           NOA36 protein
       0.23   10.8  16.8       0.32   10.3  16.8    1.1  1  Nop53           Nop53 (60S ribosomal biogenesis)
       0.31   11.0  11.2       0.53   10.3  11.2    1.2  1  Trypan_PARP     Procyclic acidic repetitive protein (PARP)
       0.35   11.3   2.2       0.64   10.4   2.2    1.4  1  RNA_pol_Rpc4    RNA polymerase III RPC4
       0.61   10.2   6.3        1.1    9.4   6.3    1.3  1  CPSF100_C       Cleavage and polyadenylation factor 2 C-termi
        3.2    7.2   8.8        6.2    6.3   8.8    1.4  1  Saw1            Single strand annealing-weakened 1
        6.5    5.4   7.2        9.6    4.8   7.2    1.1  1  Presenilin      Presenilin


Domain annotation for each model (and alignments):
>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7  12.5   5.9e-07   0.00081     348     451 ..     327     428 ..     296     431 .. 0.41

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 5.9e-07
       Nop14 348 eeededdfeedddlveseseeeeeeeeedeeeeedeeeeeeeeededdlsdleseeeeeedeleeelleeekkaaeekkekk................. 429
                 +e+de+++ ed+      seeeee eee+eee+ede +ee +e++ +++ +l++ee+ +e+  +e                +                 
  EFC36750.1 327 SEDDEEESLEDE------SEEEEEIEEESEEESEDETQEETQEDERKEQIQLDKEENAKEESCIE----------------Tqrkivkylqvdcllvtv 403
                 222222222222......11111111111111111111111111111111222222222222111................012233344455677777 PP

       Nop14 430 ...kkkkkseekakeelpytfpcPe 451
                    ++   +++++  + py f+ P 
  EFC36750.1 404 yndSSIDVDDRNKHMTYPYKFTSPV 428
                 7666666666667778888888775 PP

>> SDA1  SDA1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   9.5   6.1e-07   0.00084     113     169 ..     328     381 ..     307     479 .. 0.60

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 6.1e-07
        SDA1 113 eedseggwidvesdeeeieesdesedeeeeeeeeeekeekeeeeeeeeeeeeeeeee 169
                 e+d+e++  + es+ee +e+++ese+e+e+e++ee++e++++e+ +  ++ee+ +ee
  EFC36750.1 328 EDDEEES-LEDESEEE-EEIEEESEEESEDETQEETQEDERKEQIQL-DKEENAKEE 381
                 1111111.11111111.222222222222222222222222222111.111111111 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   6.2   6.9e-07   0.00095     129     192 ..     325     389 ..     280     474 .. 0.69

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 6.9e-07
       CDC45 129 eeesd.eedeeeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdeeeesddddersrkrr 192
                  e +d ee++ e+e+++++e eee+eee+e++++e+++e+++k++ + d+ee+ ++++  + +r+
  EFC36750.1 325 VESEDdEEESLEDESEEEEEIEEESEEESEDETQEETQEDERKEQIQLDKEENAKEESCIETQRK 389
                 33333133334444444445555555555555566666666666666666666555555555555 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.0     0.008        11      14      29 ..     191     206 ..     187     207 .. 0.91
   2 !    8.6   0.0    0.0012       1.7      11      26 ..     247     262 ..     241     265 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.008
      RCC1_2  14 LtedGeVlcWGsNsdG 29 
                 +++dG++++ G N dG
  EFC36750.1 191 ILSDGNLYSLGYNYDG 206
                 89*************9 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0012
      RCC1_2  11 scaLtedGeVlcWGsN 26 
                  +aL+++G+++ +G N
  EFC36750.1 247 VVALSNSGTIYVCGEN 262
                 68************99 PP

>> RRN3  RNA polymerase I specific transcription initiation factor RRN3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   5.6   3.2e-06    0.0044     215     292 ..     325     406 ..     289     460 .. 0.62

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 3.2e-06
        RRN3 215 veledlddeedeeleeelee.deddedddeddeesdlddlssdeeaeedee.kdeeeeslkkikelvekL..Dailtllfeh 292
                 ve ed ++e+ e+++ee ee +e+ e+++ed++++++++++ +e+++ d+e +++ee+ +++ +++v++L  D++l ++++ 
  EFC36750.1 325 VESEDDEEESLEDESEEEEEiEEESEEESEDETQEETQEDERKEQIQLDKEeNAKEESCIETQRKIVKYLqvDCLLVTVYND 406
                 5555555554444443333342233333333333333333444444444443777777888888888887335555555443 PP

>> DUF913  Domain of Unknown Function (DUF913)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.3   3.6e-05      0.05     268     331 ..     330     398 ..     215     408 .. 0.54

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.6e-05
      DUF913 268 asskseasssssssetkeeekssededvemedaeeetesesdeseeseeekekns.......lldyilnva 331
                  +++s +++s++++e +ee  s+e++++e++++++e+e +++ + ++ee+++++s       +++y+++ +
  EFC36750.1 330 DEEESLEDESEEEEEIEEE--SEEESEDETQEETQEDERKEQIQLDKEENAKEEScietqrkIVKYLQVDC 398
                 1112222222222222222..22222222222222222222222222222222223333344777766655 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   7.1   9.1e-05      0.13     234     304 ..     296     365 ..     267     371 .. 0.48

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.1e-05
       NOA36 234 kfgrqkqadgsddddddeedsdydaylkalasg.ddeddegdedddddddeedddeeeddedeeeeeeeese 304
                  fg +   +++d       + + ++  ka + + +d+++e+ ed+ ++++e ++++ee+ ede +ee +e+e
  EFC36750.1 296 DFGHDGIVATTDGYG--IVKIQRGNIIKARGVEsEDDEEESLEDESEEEEEIEEESEEESEDETQEETQEDE 365
                 455555443333333..3334444444544443133444444444444444444444433333333333322 PP

>> Nop53  Nop53 (60S ribosomal biogenesis)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3  16.8   0.00023      0.32     238     310 ..     326     392 ..     313     401 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00023
       Nop53 238 elseekdegleeeeeeeeeeeeeeeeeeeeseeeeklnapvkkkpkrKTkaqRnkekrrkeeekeekeekkek 310
                 e++++++e+le+e+eeeee eee+eee+e++     + ++++++++rK + q  ke+ +kee + e ++k  k
  EFC36750.1 326 ESEDDEEESLEDESEEEEEIEEESEEESEDE-----T-QEETQEDERKEQIQLDKEENAKEESCIETQRKIVK 392
                 2222222223333333332222222222211.....1.1234567********************99999766 PP

>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3  11.2   0.00038      0.53      23      92 ..     301     371 ..     294     391 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00038
  Trypan_PARP  23 gfaaaaegpedkgltkggkgkekgtkvsdddtngtdpepepepepepepepepepepetep.eeepepepe 92 
                  g+ a+++g     + +g   k +g + +dd+ ++ + e e e+e e e e e+e e + e  e+e +++ +
   EFC36750.1 301 GIVATTDGYGIVKIQRGNIIKARGVESEDDEEESLEDESEEEEEIEEESEEESEDETQEETqEDERKEQIQ 371
                  55566666555556666666777888888777777777777777776666666666533320222222222 PP

>> RNA_pol_Rpc4  RNA polymerase III RPC4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   2.2   0.00047      0.64      22      74 ..     326     376 ..     276     390 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00047
  RNA_pol_Rpc4  22 saaeddkseaesqsaekakaeeeskaekasgaeaeekkskkksskkkkkkksk 74 
                   ++++d++++ e++s+e+++ eees++e+++++++e++++++k++ + +k  ++
    EFC36750.1 326 ESEDDEEESLEDESEEEEEIEEESEEESEDETQEETQEDERKEQIQLDK--EE 376
                   3333333333344444444444444444444333333333333332222..22 PP

>> CPSF100_C  Cleavage and polyadenylation factor 2 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.3   0.00079       1.1      18      72 ..     308     372 ..     302     400 .. 0.35

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00079
   CPSF100_C  18 glevatvt.geleieee......a.......eeaeeeekeeeeeeeeeeeeeeeaskkqklaeksekea 72 
                 g+++++++ g++  +++      +       +    ee+ee eee+eee+e+e+++++q+ ++k++ + 
  EFC36750.1 308 GYGIVKIQrGNIIKARGveseddEeesledeS----EEEEEIEEESEEESEDETQEETQEDERKEQIQL 372
                 67777774366653332443322022221111....111111111111111111111111111111111 PP

>> Saw1  Single strand annealing-weakened 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   8.8    0.0045       6.2     188     240 ..     334     385 ..     310     387 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0045
        Saw1 188 qlneeandkpeileeaeddkqeraseeeevkdekKpkikfkYkpvinlgecid 240
                 +l++e+++++ei ee+e++ +e++ +ee ++de+K +i+   + + + ++ci+
  EFC36750.1 334 SLEDESEEEEEIEEESEEE-SEDETQEETQEDERKEQIQLDKEENAKEESCIE 385
                 5788999*********999.9999999************99999999888886 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   7.2     0.007       9.6     261     305 ..     332     376 ..     310     402 .. 0.35

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.007
  Presenilin 261 sseksaqsseseeeseeesseaessaeesseekeseessesseee 305
                 +++ +++s+e+ee +ee+++e+e++++e+++e+e++e+ + ++ee
  EFC36750.1 332 EESLEDESEEEEEIEEESEEESEDETQEETQEDERKEQIQLDKEE 376
                 111111111111111111111111111111111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2360  (0.13163); expected 358.6 (0.02)
Passed bias filter:                      949  (0.052931); expected 358.6 (0.02)
Passed Vit filter:                       239  (0.0133304); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.80u 0.31s 00:00:01.11 Elapsed: 00:00:00.49
# Mc/sec: 3087.21
//
Query:       EFC36751.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       700  (0.0390429); expected 358.6 (0.02)
Passed bias filter:                      426  (0.0237604); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1376.19
//
Query:       EFC36752.1  [L=637]
Description: hypothetical protein NAEGRDRAFT_59935 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.8e-09   36.8   1.9    6.8e-09   36.0   1.9    1.5  1  RGS         Regulator of G protein signaling domain
     0.0094   15.7   0.8      0.017   14.8   0.8    1.4  1  RGS-like    Regulator of G protein signalling-like domain
  ------ inclusion threshold ------
       0.05   14.0   2.7       0.11   12.9   2.7    1.5  1  R3H-assoc   R3H-associated N-terminal domain
       0.07   13.2   0.1       0.16   12.1   0.1    1.6  1  NRN1        Neuritin protein family
      0.078   13.4   0.2        0.2   12.1   0.2    1.6  1  Latarcin    Latarcin precursor


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.0   1.9   1.9e-12   6.8e-09       3     101 ..     496     597 ..     494     622 .. 0.89

  Alignments for each domain:
  == domain 1  score: 36.0 bits;  conditional E-value: 1.9e-12
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHH.HHHHHHHCSS..STTTTTTHHHHHHHH CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklr.eelekrleke..qpsrklfeeaqeevf 98 
                  ++l d++   ++  F +++++ e +  w++++ +k++++ +++ k ak+I n+yl++++p eln+++k   ee+ k + ++    s++ f+++ +++ 
  EFC36752.1 496 IKMLRDKKMFDILLAFAKQSYCPESVLAWKEIQLYKRKSNVKARRKLAKNIQNKYLKSDAPMELNLPSKFNkEEIGKTIDDVtkPLSKDFFNALAKHCE 594
                 57999**************************************************************99861566666666566788999999999998 PP

                 HHH CS
         RGS  99 ell 101
                 + +
  EFC36752.1 595 QDM 597
                 877 PP

>> RGS-like  Regulator of G protein signalling-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.8   4.8e-06     0.017      22     111 ..     509     599 ..     499     628 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.8e-06
                 HHHHHHHS--HHHHHHHHHHHHTT.S-TTHHHHHHHHHHHHHTSTT-TT-----HHHHHHH...HHHHHTT---HHHHHHHHHHHHHHHHH CS
    RGS-like  22 lnyvlsqfdPsallfylitdlykq.gtsKetrrvaleifstFleknallrvpvpeslalelekrrkelikeeilrrviqevrerakedink 111
                 l +      P ++l +   +lyk   ++K  r++a++i + +l+  a++  + p +   e   + +++  + + + ++  + ++ ++d+  
  EFC36752.1 509 LAFAKQSYCPESVLAWKEIQLYKRkSNVKARRKLAKNIQNKYLKSDAPMELNLPSKFNKEEIGKTIDDVTKPLSKDFFNALAKHCEQDMMD 599
                 55555556688899999999**98799*****************************99988788999999999999998887777666554 PP

>> R3H-assoc  R3H-associated N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   2.7     3e-05      0.11      17     104 ..     531     630 ..     522     636 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3e-05
   R3H-assoc  17 kgkeGsRrrrRweNdr...lLkeLlerl.........eeieed.....emdesdaepplpsdfeklptseen...aelWddflnlseeeqerilaslee 95 
                 k+k + + rr++ ++    +Lk+    +         +          + +++d++ pl++df +++ ++     + +Wd+ + ++   qe + ++ +e
  EFC36752.1 531 KRKSNVKARRKLAKNIqnkYLKS----DapmelnlpsK----FnkeeiGKTIDDVTKPLSKDFFNALAKHCEqdmMDIWDRLRKKDKRVQEFVTNYQKE 621
                 44444444444433222224444....32122333333....044447788899999999887665555555588*******************99999 PP

   R3H-assoc  96 sekkrkkke 104
                  e+k+++++
  EFC36752.1 622 CEAKKNNAA 630
                 999998885 PP

>> NRN1  Neuritin protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.1   4.4e-05      0.16      52      84 ..     591     624 ..     565     628 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.4e-05
        NRN1  52 adCqeeaaaiWesLrkeskklk.fqGsLfdlCss 84 
                  +C+++ ++iW++Lrk+ k+++ f  +  + C +
  EFC36752.1 591 KHCEQDMMDIWDRLRKKDKRVQeFVTNYQKECEA 624
                 57**************999986377776666665 PP

>> Latarcin  Latarcin precursor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.2   5.5e-05       0.2      19      50 ..     590     621 ..     558     634 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.5e-05
    Latarcin  19 rgainrklmemvnnlRkvqgRLeemvenlrkv 50 
                 ++ + + +m+ +++lRk  +R +e v n +k 
  EFC36752.1 590 AKHCEQDMMDIWDRLRKKDKRVQEFVTNYQKE 621
                 6778889*********************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (637 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1576  (0.0879023); expected 358.6 (0.02)
Passed bias filter:                      622  (0.0346924); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.46
# Mc/sec: 4144.30
//
Query:       EFC36753.1  [L=474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.6e-11   43.3  12.6    3.6e-05   23.5   0.0    6.8  7  LRR_6       Leucine Rich repeat
    8.6e-10   38.7  36.3      0.021   15.2   1.6    8.5  7  LRR_4       Leucine Rich repeats (2 copies)
    0.00072   19.4   0.3      0.002   18.0   0.3    1.8  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.019   15.6   1.3        0.4   11.4   0.1    3.8  3  LRR_2       Leucine Rich Repeat
       0.31   10.8   5.9         14    5.5   0.3    3.6  3  FTH         FTH domain
       0.54   10.1  24.1      0.084   12.7   1.8    7.0  7  LRR_8       Leucine rich repeat
       0.56   11.0  26.4        6.4    7.7   0.0    8.1  8  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.0    0.0068        18       3      21 ..     121     139 ..     119     142 .. 0.84
   2 ?   -1.7   0.0       1.7   4.4e+03       3      11 ..     148     156 ..     146     161 .. 0.76
   3 ?   -2.9   0.1       4.1   1.1e+04       1      10 [.     172     181 ..     172     183 .. 0.81
   4 !    5.6   0.0    0.0075        19       4      24 .]     250     270 ..     249     270 .. 0.93
   5 !   11.2   0.1   0.00012      0.31       3      18 ..     276     291 ..     274     293 .. 0.88
   6 !   23.5   0.0   1.4e-08   3.6e-05       3      23 ..     329     349 ..     327     350 .. 0.93
   7 ?   -1.0   0.1         1   2.6e+03       4      14 ..     415     425 ..     414     426 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0068
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 ++L++L L  N+I+De ++
  EFC36753.1 121 RNLKSLILFANEIDDECCK 139
                 79*************9555 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.7
       LRR_6   3 thLteLdLs 11 
                  +Lt Ld  
  EFC36753.1 148 KNLTRLDFG 156
                 589***986 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 4.1
       LRR_6   1 snthLteLdL 10 
                 ++ +L+ L L
  EFC36753.1 172 NCKNLRILKL 181
                 5889999987 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.0075
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L+L +N +  eG++ +a
  EFC36753.1 250 NLTSLNLCSNSFEREGCKEIA 270
                 7****************9997 PP

  == domain 5  score: 11.2 bits;  conditional E-value: 0.00012
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 + Lt+L+L g+ IgD 
  EFC36753.1 276 NQLTYLNLGGCRIGDG 291
                 579***********95 PP

  == domain 6  score: 23.5 bits;  conditional E-value: 1.4e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 t+Lt+Ld+s NdIg eG++ +
  EFC36753.1 329 TKLTYLDISNNDIGSEGVKMI 349
                 79****************998 PP

  == domain 7  score: -1.0 bits;  conditional E-value: 1
       LRR_6   4 hLteLdLsgNd 14 
                 +Lte++L +Nd
  EFC36753.1 415 NLTEVNLLFND 425
                 79*****9998 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.1   0.00025      0.63       2      37 ..      90     134 ..      89     136 .. 0.82
   2 !    9.6   0.6   0.00049       1.3       1      32 [.     148     183 ..     143     196 .. 0.81
   3 !    7.5   0.6    0.0022       5.7       1      41 [.     202     241 ..     202     244 .. 0.75
   4 !    6.6   0.7    0.0042        11      15      33 ..     244     259 ..     235     271 .. 0.78
   5 !    8.0   0.1    0.0015         4       2      28 ..     277     307 ..     276     313 .. 0.68
   6 !   15.2   1.6   8.2e-06     0.021       1      33 [.     329     365 ..     329     405 .. 0.82
   7 ?    1.1   1.2      0.23     6e+02      19      38 ..     411     425 ..     381     435 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00025
                 S--EEE--SS.---E-S-HH.........H-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnN.qltdiplle.........klpnLkeLdLsgNnlit 37 
                 nL+ Ld sn+ +l d+ +le          + nLk+L L + n i+
  EFC36753.1  90 NLTQLDASNCyRLDDFVGLEcirelcqceEMRNLKSLIL-FANEID 134
                 9*********99999999777778888856999***988.655665 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00049
                 SS--EEE--SS---.E-S-HH...H-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqlt.diplle...klpnLkeLdLsg 32 
                 +nL+ Ld++   ++  i+ l+   +++nL+ L L +
  EFC36753.1 148 KNLTRLDFGESEIReGIEYLAnseNCKNLRILKLES 183
                 69*******669**99999667779********943 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0022
                 SS--EEE--SS---.E-S-HHH-TT--EEE-.-S-----GGG CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLsgNnlitdlde 41 
                 +nL++L +++  +   ++ +++l++L++L L + ++i++ ++
  EFC36753.1 202 TNLTNLEINDIFVDeALD-FGQLTQLTSLCL-EISYIKNMEP 241
                 79********88884444.556*******88.6667776655 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0042
                 E-S-HHH-TT--EEE-.-S CS
       LRR_4  15 diplleklpnLkeLdLsgN 33 
                   +    ++nL++L+L +N
  EFC36753.1 244 RNEH---FKNLTSLNLCSN 259
                 4444...9*******9777 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0015
                 S--EEE--SS-....--E-S-.HHH-TT--EE CS
       LRR_4   2 nLevLdLsnNq....ltdipl.leklpnLkeL 28 
                 +L++L+L++++    + di + + ++ nL +L
  EFC36753.1 277 QLTYLNLGGCRigdgIIDIANsP-NMSNLSSL 307
                 69*********444433333333.58888888 PP

  == domain 6  score: 15.2 bits;  conditional E-value: 8.2e-06
                 SS--EEE--SS---E-S-......HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl......leklpnLkeLdLsgN 33 
                 ++L++Ld+snN + + +       + ++ nL++L + +N
  EFC36753.1 329 TKLTYLDISNNDIGSEGVkmivdsP-NMINLTTLMI-DN 365
                 79**********9987778866545.5*******77.65 PP

  == domain 7  score: 1.1 bits;  conditional E-value: 0.23
                 HHH-TT--EEE-.-S----- CS
       LRR_4  19 leklpnLkeLdLsgNnlitd 38 
                 le   nL+e++L +N    d
  EFC36753.1 411 LE-VANLTEVNLLFN----D 425
                 44.567777777666....3 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.3   7.8e-07     0.002       6      35 ..      32      63 ..      28      68 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 7.8e-07
  F-box-like  6 dEiLlqIFsyL.ppsdLlr.lalVCrrWrrva 35
                d+iLl I+ +L + +++++ ++lV+++W + +
  EFC36753.1 32 DDILLNILPFLhNRKEIIPiCSLVSKQWFDQC 63
                79*********7788****99*******8876 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         7   1.8e+04      10      22 ..      70      82 ..      69      82 .. 0.80
   2 ?   11.4   0.1   0.00016       0.4       1      26 []     122     145 ..     122     145 .. 0.91
   3 ?   -0.2   0.0      0.71   1.8e+03       2      15 ..     251     264 ..     250     267 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 7
       LRR_2 10 VrfsdedslekLL 22
                ++ + + +l++LL
  EFC36753.1 70 IKLTRGSTLNNLL 82
                6778889999998 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00016
       LRR_2   1 sLKtLhLdsVrfsdedslekLLSgCP 26 
                 +LK+L L  ++++de  ++kL+   P
  EFC36753.1 122 NLKSLILFANEIDDE--CCKLIATSP 145
                 6**************..****98666 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.71
       LRR_2   2 LKtLhLdsVrfsde 15 
                 L +L+L s+ f  e
  EFC36753.1 251 LTSLNLCSNSFERE 264
                 779******99655 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.3    0.0054        14      42     106 ..     148     212 ..     108     220 .. 0.82
   2 ?    4.9   0.3    0.0081        21      42      82 ..     224     263 ..     201     279 .. 0.75
   3 ?    1.5   0.1     0.093   2.4e+02       8      52 ..     347     394 ..     343     421 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0054
         FTH  42 gtLeeIelsseeeeeefeelveleQWKnAkklkiessklssfpiehlfhFeefeikldkfsveda 106
                 ++L  +++ ++e  e +e l ++e  Kn + lk+es ++ +++i + +   +  ++l+++ ++d+
  EFC36753.1 148 KNLTRLDFGESEIREGIEYLANSENCKNLRILKLESLFNANKSILKALAYGKYFTNLTNLEINDI 212
                 46888999999999999*****************9999998888877777777777777776665 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0081
         FTH  42 gtLeeIelsseeeeeefeelveleQWKnAkklkiessklss 82 
                  +L ++ l + + ++++e +++ e++Kn  +l+++s++++ 
  EFC36753.1 224 TQLTSLCL-EISYIKNMEPITRNEHFKNLTSLNLCSNSFER 263
                 45666666.77788899999999999999999999988865 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.093
         FTH   8 kkilkskkclkvkklsleglsfkdvasiLss.fkagtLeeIel..sse 52 
                 k i +s ++++  +l ++++  +d  +++s+ + +++L+ I++  +++
  EFC36753.1 347 KMIVDSPNMINLTTLMIDNCGSDDSYNLISHsVFSNQLKIINIdnFDW 394
                 556777899999*****************99888889*****976333 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.3      0.43   1.1e+03      49      58 ..      89      98 ..      71     114 .. 0.63
   2 ?    0.0   0.1      0.29   7.4e+02      47      61 .]     119     133 ..     116     133 .. 0.71
   3 ?    2.4   0.6      0.05   1.3e+02      23      39 ..     146     162 ..     121     183 .. 0.56
   4 ?   -3.3   0.0       3.1     8e+03      21      28 ..     201     208 ..     199     209 .. 0.69
   5 ?   12.7   1.8   3.3e-05     0.084       2      61 .]     225     288 ..     224     288 .. 0.83
   6 ?    4.6   0.1     0.011        28      49      61 .]     329     341 ..     325     341 .. 0.65
   7 ?   -3.1   0.1       2.7     7e+03      19      32 ..     378     389 ..     371     392 .. 0.53

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.43
                -S-.EEE--S CS
       LRR_8 49 psLrsLdLsg 58
                ++L++Ld s+
  EFC36753.1 89 SNLTQLDASN 98
                4444444443 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.29
                 T--S-.EEE--SS-- CS
       LRR_8  47 gLpsLrsLdLsgNrL 61 
                  +++L+sL L  N +
  EFC36753.1 119 EMRNLKSLILFANEI 133
                 577888888887765 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.05
                 T-TT--EEE--SS---G CS
       LRR_8  23 glsnLkvLdLsnNlltt 39 
                  l+nL+ Ld ++ +++ 
  EFC36753.1 146 YLKNLTRLDFGESEIRE 162
                 38899999999988876 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 3.1
                 STT-TT-- CS
       LRR_8  21 FkglsnLk 28 
                 F++l+nL+
  EFC36753.1 201 FTNLTNLE 208
                 77777776 PP

  == domain 5  score: 12.7 bits;  conditional E-value: 3.3e-05
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT...--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsg...LpsLrsLdLsgNrL 61 
                 +LtsL L  ++++++++ + +  ++nL++L+L +N+ ++   + +++   L++L++L+L g+r+
  EFC36753.1 225 QLTSLCLEISYIKNMEPITRNEhFKNLTSLNLCSNSFEREGCKEIANskyLNQLTYLNLGGCRI 288
                 799***************99988************998754444443333999******99987 PP

  == domain 6  score: 4.6 bits;  conditional E-value: 0.011
                 -S-.EEE--SS-- CS
       LRR_8  49 psLrsLdLsgNrL 61 
                 ++L++Ld+s+N++
  EFC36753.1 329 TKLTYLDISNNDI 341
                 4666666666665 PP

  == domain 7  score: -3.1 bits;  conditional E-value: 2.7
                 TSSTT-TT--EEE- CS
       LRR_8  19 eaFkglsnLkvLdL 32 
                 ++F+  ++Lk++++
  EFC36753.1 378 SVFS--NQLKIINI 389
                 4444..35555554 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.2       0.3   7.8e+02       1      13 [.      90     102 ..      90     115 .. 0.81
   2 ?   -2.0   3.1       3.8   9.8e+03       1       1 [.     175     175 ..     122     238 .. 0.70
   3 ?    6.8   0.3     0.005        13       1      15 [.     250     264 ..     250     273 .. 0.80
   4 ?    6.9   0.1    0.0048        12       1      17 [.     277     293 ..     277     306 .. 0.85
   5 ?    7.7   0.0    0.0025       6.4       1      14 [.     330     343 ..     330     354 .. 0.84
   6 ?    0.3   0.1       0.7   1.8e+03       1      13 [.     357     369 ..     357     382 .. 0.78
   7 ?   -2.4   0.0       5.4   1.4e+04       2       9 ..     384     391 ..     383     406 .. 0.72
   8 ?   -2.3   0.0       5.1   1.3e+04       1      10 [.     415     424 ..     415     453 .. 0.59

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.3
       LRR_1   1 nLrhLdLsnnpll 13 
                 nL+ Ld sn+  l
  EFC36753.1  90 NLTQLDASNCYRL 102
                 8999******974 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 3.8
       LRR_1   1 n 1  
                 n
  EFC36753.1 175 N 175
                 2 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.005
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL++L+L++n++++ 
  EFC36753.1 250 NLTSLNLCSNSFERE 264
                 8**********9654 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0048
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L+L+++++++ ++
  EFC36753.1 277 QLTYLNLGGCRIGDGII 293
                 599********966654 PP

  == domain 5  score: 7.7 bits;  conditional E-value: 0.0025
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++Ld+snn +++
  EFC36753.1 330 KLTYLDISNNDIGS 343
                 79********9854 PP

  == domain 6  score: 0.3 bits;  conditional E-value: 0.7
       LRR_1   1 nLrhLdLsnnpll 13 
                 nL++L + n+  +
  EFC36753.1 357 NLTTLMIDNCGSD 369
                 89*****999873 PP

  == domain 7  score: -2.4 bits;  conditional E-value: 5.4
       LRR_1   2 LrhLdLsn 9  
                 L+ +++ n
  EFC36753.1 384 LKIINIDN 391
                 89999843 PP

  == domain 8  score: -2.3 bits;  conditional E-value: 5.1
       LRR_1   1 nLrhLdLsnn 10 
                 nL++ +L  n
  EFC36753.1 415 NLTEVNLLFN 424
                 6777776333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       460  (0.0256568); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 3214.86
//
Query:       EFC36754.1  [L=320]
Description: K+ channel tetramerization domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-20   73.1   0.1      3e-20   72.3   0.1    1.4  1  BTB_2     BTB/POZ domain
    0.00011   22.3   0.1    0.00017   21.6   0.1    1.3  1  SPRY      SPRY domain


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.3   0.1   3.4e-24     3e-20       1      91 [.      60     149 ..      60     152 .. 0.95

  Alignments for each domain:
  == domain 1  score: 72.3 bits;  conditional E-value: 3.4e-24
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS..S-B---TTS-HHHHHHHHHHHT--TT-B CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtg.gkLhrpeevelkslleElefygleelll 91 
                 +kl+VgG++f+ts++tL  k dt++ ++ +  + +   +e+++yf+DR+pklF+++L+++r g ++L   ++ + + l+eE+++y ++e + 
  EFC36754.1  60 IKLDVGGKIFKTSRETLLSKKDTFFYAMIS--SGKWLPDEDGSYFIDRNPKLFHYVLDFMRYGkVDLSALDKSKRDLLREEADYYLISEMFS 149
                 79****************************..46999999***********************************************99865 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.1     2e-08   0.00017       4      85 ..     205     286 ..     202     319 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 2e-08
                 EEEEET..CCTSSEEEEEEEETTSSSSSTSSSTSSTTEEEEETETTEEEEETESCEEEESSSSTTSEEEEEEETTTTEEEEEET CS
        SPRY   4 fevkiq..saeggsisvGlateqtdlsdksgegddrgswglcgdngtrtsaeqskaygkqparegdviGvalDleegelsFtkn 85 
                 ++ +++    +++ i+vG+a ++   +++s+  +++  +g++++n+++t  ++s+ ++++ +  g +i v lD+++++l+ t+ 
  EFC36754.1 205 WKLRMNhfASTSHWIMVGVASKPLTDYQNSF--EQPNNFGISSRNQKFTDCSSSSTTASNDWAVGHIIQVDLDCSKNTLKITNL 286
                 666666667789999**********777777..79999***********888888888889*****************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       978  (0.0545485); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2141.76
//
Query:       EFC36755.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.8e-36  124.8   0.0    3.9e-36  124.3   0.0    1.2  1  VWA_3            von Willebrand factor type A domain
     0.0025   18.1   0.0     0.0039   17.5   0.0    1.3  1  VWA              von Willebrand factor type A domain
  ------ inclusion threshold ------
      0.013   15.3   0.0      0.025   14.4   0.0    1.5  1  RRM_1            RNA recognition motif. (a.k.a. RRM, RBD, or 
      0.019   14.8   0.5      0.037   13.9   0.5    1.4  1  Peptidase_C25_C  Peptidase family C25, C terminal ig-like dom


Domain annotation for each model (and alignments):
>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  124.3   0.0   8.6e-40   3.9e-36       2     155 .]      74     223 ..      73     223 .. 0.98

  Alignments for each domain:
  == domain 1  score: 124.3 bits;  conditional E-value: 8.6e-40
       VWA_3   2 evvivvDvsssmsaen.klvkdaLsvalrq..Lptnd.kiavllfgtkprplfpgsravsaaelqealqkikelels.lgasnlegaLkealrqpakpg 95 
                 ++vi+ D+s+sm++++ k+++d++++++++  ++t+d ki+++l+g++++ +f++ +++++++l++++q+++ ++++ lg++ l++aL++++r+++k  
  EFC36755.1  74 QIVILGDASVSMKGSPfKTLIDCFNNFVQSkaFNTGDlKISIALWGSTTE-WFKHGDTIEPTDLDALNQFLNVWSVPlLGNTLLKQALNQTFRKFPK-- 169
                 8****************************999****************66.**************************9****************988.. PP

       VWA_3  96 evrsvilltDgss.aqgeervsdlisrarekirfhalglgsslsaamlqaLAeasgGtyef 155
                  ++++++++Dg++ + ++ +++++i++a     fh++g+gs  sa+++q++A++++G+yef
  EFC36755.1 170 -IENILIMCDGHIqDISSVDAFKSIRDA-----FHFTGIGS-GSAPNMQEMAQYGNGIYEF 223
                 .************99*************.....********.*****************98 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   8.7e-07    0.0039       2     165 ..      75     225 ..      74     231 .] 0.74

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 8.7e-07
                 EEEEEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSS..EEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHGT CS
         VWA   2 ivfvlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfsse..vktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssag 98 
                 iv++ D+S sm ++ f++  ++ +++v++   +  + ++++   +s+  +  + +  + ++ ++l++ ln  ++   g+t     lk+al++ f++  +
  EFC36755.1  75 IVILGDASVSMKGSPFKTLIDCFNNFVQSKAFNTGDLKISIALWGSTteWFKHGDTIEPTDLDALNQFLNVWSVPLLGNT----LLKQALNQTFRKFPK 169
                 89**************************9997555555666666644115555555555599999999999966555555....477777788889999 PP

                 SSTTSEEEEEEEESS--CSSHTHHHHHHHHGCTEEEEEEEESSSHHHHHHHHHSSSSCHHCEEEESS CS
         VWA  99 aRenakkviilltdGksndgdpkeaaneakeqgikvfavGvgnadekelLnkiasepgeghvftvtd 165
                         i+++ dG+ +d +  +a ++++++   ++  G+g+    + ++++a+ ++   +++++d
  EFC36755.1 170 -----IENILIMCDGHIQDISSVDAFKSIRDA---FHFTGIGSGSAPN-MQEMAQYGN--GIYEFSD 225
                 .....8889999*****995555566666655...8888888888888.888888777..5555555 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.0   5.5e-06     0.025       7      34 ..     152     179 ..     148     196 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 5.5e-06
                 TTTSSHHHHHHHHHTTSCEEEEEEEEET CS
       RRM_1   7 ppdvteeeLkelFskfGpiksiklvrde 34 
                  +++ ++ L + F+kf +i++i +++d 
  EFC36755.1 152 GNTLLKQALNQTFRKFPKIENILIMCDG 179
                 5667789*******************93 PP

>> Peptidase_C25_C  Peptidase family C25, C terminal ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.5   8.3e-06     0.037       5      51 ..      35      77 ..      32      86 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 8.3e-06
                     -EE--SEEETT-SEEEEEESSTT-EEEEEETTEEEEEEE-BTTEEEE CS
  Peptidase_C25_C  5 tvtaPasiplgtnsievscdvdgalvalSannkllGsaivasGqatl 51
                     ++  Pa+++  +  +++++     l + S+n kl Gs i ++Gq ++
       EFC36755.1 35 KIIEPAQVTTRADALKINTS----LKTTSKNSKLAGSSIIEEGQIVI 77
                     67889999999999999876....99******************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       373  (0.0208043); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.39u 0.26s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 1736.87
//
Query:       EFC36756.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       835  (0.0465726); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1006.41
//
Query:       EFC36757.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      0.007   16.0   0.8      0.083   12.4   0.8    2.0  1  Pox_E8         Poxvirus E8 protein
     0.0083   16.1   1.6      0.018   15.0   1.4    1.5  2  Reticulon      Reticulon
  ------ inclusion threshold ------
      0.029   14.1   0.3      0.037   13.8   0.3    1.4  1  EMC3_TMCO1     Integral membrane protein EMC3/TMCO1-like
       0.21   11.4   2.1       0.25   11.1   0.7    1.8  2  Brr6_like_C_C  Di-sulfide bridge nucleocytoplasmic transport 
        9.5    6.7   7.6         23    5.5   7.6    1.5  1  PhoR           Phosphate regulon sensor protein PhoR


Domain annotation for each model (and alignments):
>> Pox_E8  Poxvirus E8 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.8   2.3e-05     0.083     120     225 ..      12     144 ..       6     151 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.3e-05
      Pox_E8 120 tllsevytdndkhvelakylrrgGdykPlfsrldedniytk....................klplneaeillkntskgl..alsdy..etlanlsaily 194
                 +lls+  ++    + l +y ++   +k +f+rl + + + +                    ++  n+  +  ++  k++  +++++  e l+++++++ 
  EFC36757.1  12 SLLSSSSVTASASMRLCHYNHHQQQFKSIFKRLANIQSLINpnrqfsssiirrnqaaekptNVDENKDAAVPREEKKSFirNVMEFigEFLEEMASMIL 110
                 6788888888899999999999999*****999995554444888888999999888664433333322222222222223555655678888866554 PP

      Pox_E8 195 ...ltkydPvliflvfyvPglsvttkitPaveyl 225
                    l    P+l+++ fy  +  vtt++t a  ++
  EFC36757.1 111 wrlLIFVVPILCIVWFYFGSSGVTTALTLAWVFI 144
                 12245678*******************9887776 PP

>> Reticulon  Reticulon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.34   1.2e+03      67      98 ..      10      41 ..       2      51 .. 0.72
   2 !   15.0   1.4     5e-06     0.018      63     139 ..      65     150 ..      14     151 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.34
   Reticulon 67 pelelseesvreladsllellnkalselrrla 98
                p   ls +sv   a+  l + n+ ++++++++
  EFC36757.1 10 PSSLLSSSSVTASASMRLCHYNHHQQQFKSIF 41
                55557777777777777888888888888887 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 5e-06
   Reticulon  63 kp.........pepelelseesvreladsllellnkalselrrlalgedlklflkvalllyilsilgslfslltllyigvvlaftv 139
                 ++         + ++  +++e+ +++++++ e + ++l+e+ +++l + l   + +++++++      +++ ltl+ + +v++ft+
  EFC36757.1  65 NQaaekptnvdENKDAAVPREEKKSFIRNVMEFIGEFLEEMASMILWRLLIFVVPILCIVWFYFGSSGVTTALTLAWVFIVAIFTA 150
                 22233334444559********************************99999999999999999989999999**********9996 PP

>> EMC3_TMCO1  Integral membrane protein EMC3/TMCO1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.3     1e-05     0.037      67     121 ..      84     138 ..       7     152 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1e-05
  EMC3_TMCO1  67 klklkklekrqeelmedqsemmmdqmkpmivtmipqiliffwlnsffsgfvvakl 121
                 ++ +k++ +  +e++++  e m +++   + ++++ il + w+++  sg+++a  
  EFC36757.1  84 REEKKSFIRNVMEFIGEFLEEMASMILWRLLIFVVPILCIVWFYFGSSGVTTALT 138
                 567899999999999999999***************************9998433 PP

>> Brr6_like_C_C  Di-sulfide bridge nucleocytoplasmic transport domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.7     7e-05      0.25      87     125 ..      89     127 ..      76     134 .. 0.84
   2 ?   -1.6   0.0       0.6   2.1e+03      14      26 ..     137     149 ..     130     160 .. 0.52

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 7e-05
  Brr6_like_C_C  87 erakvsaetlaeiinsfvepislktllfllllllivlfv 125
                    +  + ++e ++e ++++ + i ++ l+f++ +l+iv+f 
     EFC36757.1  89 SFIRNVMEFIGEFLEEMASMILWRLLIFVVPILCIVWFY 127
                    5567789**********************9999988875 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.6
  Brr6_like_C_C  14 llllylvisfvlt 26 
                    l+l++++i  ++t
     EFC36757.1 137 LTLAWVFIVAIFT 149
                    3333444444444 PP

>> PhoR  Phosphate regulon sensor protein PhoR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   7.6    0.0064        23       5      40 ..     109     145 ..     106     150 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0064
        PhoR   5 lllrlallllaal.lvgllvgalaallllalllllaw 40 
                 +l+rl+++++++l +v++++g  + + +l+l+++ + 
  EFC36757.1 109 ILWRLLIFVVPILcIVWFYFGSSGVTTALTLAWVFIV 145
                 69*********99788889999888888777776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1469  (0.0819343); expected 358.6 (0.02)
Passed bias filter:                      800  (0.0446204); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 989.51
//
Query:       EFC36758.1  [L=512]
Description: hypothetical protein NAEGRDRAFT_82150 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.7e-11   42.0   0.2      7e-10   39.2   0.0    2.6  2  RGS            Regulator of G protein signaling domain
  ------ inclusion threshold ------
        0.1   12.7   0.1       0.24   11.5   0.1    1.6  1  Lipase_GDSL_3  GDSL-like Lipase/Acylhydrolase family


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.2   0.0   7.8e-14     7e-10       3     114 ..      18     181 ..      16     185 .. 0.95
   2 ?   -3.6   0.1       1.4   1.3e+04      42      59 ..     486     503 ..     474     508 .. 0.50

  Alignments for each domain:
  == domain 1  score: 39.2 bits;  conditional E-value: 7.8e-14
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...................................SHHHHHHHHHHHHHHHHTSTTSTTSS CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkka...................................keqeelkkkakeIyneylapsspkel 66 
                 e+l++ +  r  F eFl++ ++ee + F+ +v+ +++                                    k  + ++++ k+I+++y+  + pkel
  EFC36758.1  18 EELMKVSEARDNFHEFLKQAHNEEPILFLNDVDAYRTLykktkeqitqytntcispgsetgelqnkefdtqciKLMSVVVDALKNIIDTYIGGGKPKEL 116
                 78999999*****************************9***********************************99************************ PP

                 TS-HHHHHHHHHHHCSS.................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHH CS
         RGS  67 nidkklreelekrleke.................qpsrklfeeaqeevfellekdsypkFlksel 114
                 n++k + + + + +                        +lf+++ ++v   l+ d++p++ +s l
  EFC36758.1 117 NLSKPTYQPTLDIFDRLttlisqndmkplglislLDPFELFDRIVSHVVLDLKYDQFPRYARSHL 181
                 ******999888887778889999*********977779***********************986 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHHHHHHTS CS
         RGS  42 eqeelkkkakeIyneyla 59 
                   ee +k  ++ y+ey  
  EFC36758.1 486 AVEENLKLNRNWYEEYQR 503
                 334444444444444444 PP

>> Lipase_GDSL_3  GDSL-like Lipase/Acylhydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   2.6e-05      0.24      75     124 ..      22      71 ..      10     106 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.6e-05
  Lipase_GDSL_3  75 eirerleyfvktlrkahPktpillvedlsttkglvdeklekeveaknkal 124
                    +++e  ++f + l++ah + pil+++d++++++l++++ e+ ++ +n+ +
     EFC36758.1  22 KVSEARDNFHEFLKQAHNEEPILFLNDVDAYRTLYKKTKEQITQYTNTCI 71 
                    5778889999*************************998887777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (512 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       776  (0.0432818); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 3070.88
//
Query:       EFC36759.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-38  132.0   0.1    2.7e-38  131.5   0.1    1.2  1  DEAD      DEAD/DEAH box helicase
     0.0011   19.0   0.0     0.0016   18.5   0.0    1.5  1  ResIII    Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.5   0.1     3e-42   2.7e-38       1     166 [.      66     228 ..      66     238 .. 0.93

  Alignments for each domain:
  == domain 1  score: 131.5 bits;  conditional E-value: 3e-42
                 -HHHHHHHHHHHTTCEEEEEESTTSSHHHHHHHHHHHHHHHS..TTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHHTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   1 tdiQaeaiplilgggdvlvaaeTGsGKTlaflipvlqivyet..kgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskldng 97 
                 t++Q+++ip++l+g+d+lv+a+TGsGKTlafl+p+l+++ +   k ++g+ +++v+PtreLa qt+  +k+++ ++  + +l++g ++ ++q+++l +g
  EFC36759.1  66 TPVQSHSIPIALDGKDLLVQANTGSGKTLAFLLPCLEALHRAkfKPRNGTGVIVVSPTRELAIQTHAVCKSLMTFMPQTSCLLVGAQSLQEQVETLGKG 164
                 89*************************************8889999999*************************99888899**************999 PP

                 CSEEEEEHHHHHHHH.HCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTTSTTTSEEEEEE CS
                 xxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  98 vdivvgtpgrlddll.stgklnlsqvrflVlDEadrlldqgfsdfinrilnqlpqitcdgklqrqvivlS 166
                 + +v++tpgrl+d+l  t ++  s++  lVlD +d +  +gf++++++i++ l+          q++++S
  EFC36759.1 165 CSVVIATPGRLLDHLfGTTRFMHSNLISLVLDDIDFMVGMGFEQELKEIAKMLSY------TRIQTLIFS 228
                 *************886889999***************************999932......234466666 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   1.8e-07    0.0016      24      79 ..      79     139 ..      18     185 .. 0.81

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.8e-07
                 TSEEEEEESTTSTHHHHHHHHHHHH-S..........-EEEEESSHHHHHHHHHHGGGGTG CS
      ResIII  24 dkrglikmaTGtGKTlvaaklierllkkgkee.....kflflvprkslleqtleefkkfls 79 
                  k +l+++ TG+GKTl  +  + + l+ +k +      ++++ p+++l  qt    k+++ 
  EFC36759.1  79 GKDLLVQANTGSGKTLAFLLPCLEALHRAKFKprngtGVIVVSPTRELAIQTHAVCKSLMT 139
                 57899*************7777776666666679999***************955554443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       589  (0.0328518); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1531.46
//
Query:       EFC36760.1  [L=728]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-32  112.4   0.0    3.2e-32  111.6   0.0    1.3  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    9.7e-06   25.5   5.8    1.5e-05   24.9   5.8    1.2  1  dCache_1       Cache domain
  ------ inclusion threshold ------
       0.68    9.5   8.6        0.8    9.3   3.9    2.5  2  Baculo_11_kDa  Baculovirus 11 kDa family
        5.6    6.9   8.5         20    5.1   0.3    2.5  2  LapA_dom       Lipopolysaccharide assembly protein A domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.6   0.0     7e-36   3.2e-32       8     178 ..     485     661 ..     481     666 .. 0.89

  Alignments for each domain:
  == domain 1  score: 111.6 bits;  conditional E-value: 7e-36
  Guanylate_cyc   8 evtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeev.aves...keg 99 
                    +vt+lF+dI++ft+++++++p  +v+ L e+ +r  + + e +++ +k+iGda+m+  ++p + ++ha+k+++ aL + ++l+   +v +    ++
     EFC36760.1 485 NVTLLFSDIENFTTICEKMDPNTLVQCLSEYLERATHHIIESGGTVDKFIGDAIMAFWNAPFAIEDHAYKACNSALRIQKELKDLyRVWEkkgLPE 580
                    8****************************************************************************998885431322222479* PP

  Guanylate_cyc 100 lkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagk..iqvseetyellkeeqfeltergevevkGkgklet 178
                    +k r+G+htG+ ++g +G  ++++y+  G++vn Asr+e   k++    ++s++ty + + +   +  +++v vkGk k   
     EFC36760.1 581 FKTRIGVHTGSAFIGNVGtPERMNYTALGDNVNSASRIEGINKNYGtyLAISQATYVQVS-NRLFCVPLDSVTVKGKTKPLV 661
                    ******************999*******************99986522678********9.888899*********977654 PP

>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   5.8   3.4e-09   1.5e-05      17     248 ..      98     369 ..      86     370 .. 0.60

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 3.4e-09
    dCache_1  17 qlanniedvlds...........lenlaetlasnpslqdlleepnra.........neasreslqallksilksnpdisgvylvdadGqviassdpssp 95 
                 ++a+n+ ++l++           ++n+ +t+  + ++++++ +               +  +++  + + +++ +++ +g+++ +++G  +++ +ps +
  EFC36760.1  98 GYAKNLANYLNTkfkpavdlstiYKNQFMTFKWDLHIVNHMYN---VfkgmnpdsiFTSVGDKTGYYAWGVQNIYSFANGLFV-SKEGADFFVVTPSGE 192
                 4444444444443444433333344555555554444444422...1322222222222222222233335555555566665.555554555566655 PP

    dCache_1  96 pnleg...tddpadrdwykealaggggkpvisdp.yvdqtggkpvitiavpiyddsgkfiGvlaadldldnlqdllsniklgetgyvfivdsdGniiah 190
                  nl +   + d ++++++k    ++++++ ++d+ y +q+ ++ +i++++p  +d g+f  +        +l++++++ +++++  ++++d++G++i +
  EFC36760.1 193 VNLIVhvpGVDNTQSPYWKLMNVSNPKES-WTDVgY-NQVDPDFYISYVTPFWVD-GEFHYAWSSVTFGRSLSSFMQSTPVSKNAVTMLIDRNGLLIGS 288
                 5665588899*******995555555588.***955.455689***********7.****999999999****************************** PP

    dCache_1 191 pdkdl..................................lgknlrdelkaqealekalakiesgvssvklngeeylvayapiptglgWylvv 248
                 +++++                                  + k+l  +      +++    i+   ++v+ n   y  +++ i++  +W++v+
  EFC36760.1 289 SSPSDpsyiikngipvqttplegnttfvkegyqkllslyDLKKLNGT------ASTS---IQWNGYDVDVNAIPY-SYSSSING-MDWIIVI 369
                 88655566777777766666665555555554443333322222222......2222...344444444444455.77888885.9999986 PP

>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   3.9   0.00018       0.8      37      82 ..      59     104 ..      42     106 .. 0.87
   2 ?    1.7   0.1     0.041   1.9e+02      28      65 ..     385     422 ..     375     440 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00018
  Baculo_11_kDa  37 vLvicglvvfvvivlfilLlvvilknaeaeeaekekrektllaNld 82 
                    +L++c lv++v++vl i+  +  ++   ++    +k ++ +++Nl 
     EFC36760.1  59 LLLVCVLVLVVLVVLIITWFIGFNTGNTSVLDMNTKLKEGYAKNLA 104
                    7889999999999999999999999999999999999999*99985 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.041
  Baculo_11_kDa  28 rNrsflrdFvLvicglvvfvvivlfilLlvvilknaea 65 
                    rN  ++   +++ ++ vvfv  +l    l +++k +++
     EFC36760.1 385 RNGLLISLGIMIFGAAVVFVFSLLITFPLSSLSKDINK 422
                    67777777788999999999877766656655554444 PP

>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   2.8    0.0077        35       8      39 ..      51      81 ..      51      98 .. 0.84
   2 ?    5.1   0.3    0.0044        20      23      54 ..     391     433 ..     374     441 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0077
    LapA_dom  8 vnflfaqvelpLsllllvafgiGallgwllsl 39
                +nflf+   l L+ +l++++++ ++++w++++
  EFC36760.1 51 LNFLFSI-RLLLVCVLVLVVLVVLIITWFIGF 81
                6999998.*********************998 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0044
    LapA_dom  23 llvafgiGallgwllslwsyl.....r......lrrelrrlkk 54 
                  l+ +++Ga +++++sl+  +             r+e++++k+
  EFC36760.1 391 SLGIMIFGAAVVFVFSLLITFplsslSkdinkiARLEISSKKQ 433
                 478999*******999965552222213444456666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (728 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1027  (0.0572815); expected 358.6 (0.02)
Passed bias filter:                      589  (0.0328518); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.76u 0.34s 00:00:01.10 Elapsed: 00:00:00.50
# Mc/sec: 4347.01
//
Query:       EFC36761.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-44  152.4   0.1    1.8e-44  152.0   0.1    1.1  1  DUF917    Protein of unknown function (DUF917)


Domain annotation for each model (and alignments):
>> DUF917  Protein of unknown function (DUF917)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  152.0   0.1     1e-48   1.8e-44      77     311 ..      13     253 ..       5     281 .. 0.86

  Alignments for each domain:
  == domain 1  score: 152.0 bits;  conditional E-value: 1e-48
                 HHHHHHHHH....T--EEEEE-SSSSCCHHHHHHHHHHHHT-EEESB-SSSS--SSGGGSHHHHTT----SEEEE-SSS..-EEEEEE.---HHHHHHH CS
      DUF917  77 avealekll....grkidavislEiGGlNglvallaaaklglpvvDaDgmGRAfPelqqttfavagisltPlaladekg..nvvllkkaqsdkavErll 169
                 a++a ++++    g+++d+++++E+G+lN+l+++l++a++g+pv+  D mGRA+P+l++t+++++gis  P++l++++   ++v +   +s  avE l+
  EFC36761.1  13 AYNAFNQYVvqsqGQHVDYLVPVEVGALNSLMPMLVSAQTGIPVILSDSMGRAVPTLTMTSYSANGISTNPSILSNANTpaDSVAILL-DSASAVEALA 110
                 4555555554444888**********************************************************99885223333333.34447***** PP

                 HHHCT..TTTTEEEEEEEEE-HHHHHH--SBSHHHHHHHHHHHHHTT--..-SHHHHHHHHHH-EEEEEEEEE--------------EEEET....... CS
      DUF917 170 Raalv..emgsfagvaaypmtgaelkraavpgtlslalriGravaeareakdvveailealgggakvlfkGkivdverrteggfdvgevtiegldedeg 266
                 R++++  e+ s ag+a + mtg+++k++ vpg +  al  G   + a  ++++++++ e+l++  kv++ G   ++   t+ggfd+g+vti   + + +
  EFC36761.1 111 RPIISssEFNSVAGLALWKMTGQQCKNYSVPGGIPIALAAGYMSKLASTSENPLATLQESLKY-GKVVVVGSFKQQ-IVTSGGFDLGSVTIID-NTNPN 206
                 ***997789***************************************889***********7.555999999977.6899**********62.33448 PP

                 EEEEEEESSSEEEEE..ET..-SEETTSEEEEEHHB-SSSSB-TTTT CS
      DUF917 267 relkiefqNEnllaeedge..vlatvPDlIsvldaetgepigteelr 311
                 +++ + +qNEnl+++   +  +l t PD+I+++  ++g+ +++ +l+
  EFC36761.1 207 NQVVVYNQNENLFVYSSLQssPLLTGPDVIAYIRVKDGTFLSNADLQ 253
                 89*************544477*****************999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       548  (0.030565); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 2079.80
//
Query:       EFC36762.1  [L=548]
Description: hypothetical protein NAEGRDRAFT_82151 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.1e-06   26.6   0.8    8.8e-06   25.5   0.4    1.8  2  F-box-like  F-box-like
    0.00071   19.4   0.2     0.0017   18.1   0.2    1.6  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.016   15.3   0.7      0.026   14.6   0.7    1.5  1  RAMPs       RAMP superfamily
       0.39   11.0   5.8         73    3.9   0.0    4.4  4  TPR_2       Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       2.3     1e+04      11      17 ..      92      98 ..      91     100 .. 0.80
   2 !   25.5   0.4     2e-09   8.8e-06       6      44 ..     269     305 ..     269     309 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 2.3
  F-box-like 11 qIFsyLp 17
                ++FsyL+
  EFC36762.1 92 YVFSYLE 98
                69***97 PP

  == domain 2  score: 25.5 bits;  conditional E-value: 2e-09
  F-box-like   6 dEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrr 44 
                 dEi+  +FsyLp ++  +++ +Cr Wr +a+   +L rr
  EFC36762.1 269 DEIIYAVFSYLPIYSVMQVSSTCRLWRHLAA--KSLSRR 305
                 7*****************************4..467666 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.2   3.9e-07    0.0017       7      37 ..     268     298 ..     266     306 .. 0.92

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 3.9e-07
                 -HHHHHHHHHTS-HHHHHHHCTT-HHHHHHH CS
       F-box   7 PsevlrhILerLplsdllalrrVSkgwrili 37 
                  +e++  ++++Lp  ++   +++++ wr l 
  EFC36762.1 268 NDEIIYAVFSYLPIYSVMQVSSTCRLWRHLA 298
                 5899************************985 PP

>> RAMPs  RAMP superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.7   5.7e-06     0.026      25     121 ..      11     301 ..       3     444 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 5.7e-06
                 ...---S----HHHHHHHHHHHHHHHHH.HHHTT-HHHHH.H......................................................... CS
       RAMPs  25 frdkgglPyIPGSSlkGalRsalekllgsekkekkdeysrkkekqrvkkgd................................................ 75 
                 f + +g P +  SSl G+lR++ e  +        +e+++k+++++vk+++                                                
  EFC36762.1  11 FLHYTGCPLVAKSSLLGMLRNYRESKTM----QSIEEDLKKASDKKVKAILyvqraflevqaahekeakrsmelalemdesvgnvyvfsyleacchaia 105
                 77899***************87776666....5556667777777788888888899999999999999999999999999999999999999999999 PP

                 ..........................................HHHHHH..........--S...SS--SEEEEE......................... CS
       RAMPs  76 ..........................................leeaiF..........GneeeskiagrvffeDarpvkipgqileeskqikstpsp.. 120
                                                           + e+++          G+     +a+ + f  a+++ + +q+ e +k+i  ++++  
  EFC36762.1 106 cdfdqatkllirtrdllqdsthahlkseietkvnacceqnklIYEKVWssffskapstGSL---ISAEELDFNIAVSLYNSCQYAECVKIIDDIYLAad 201
                 9999999999999999999999999999999999999888886666666666666677777...88888888888888888888888888888877777 PP

                 ................................................................................................... CS
       RAMPs 121 ................................................................................................... 120
                                                                                                                    
  EFC36762.1 202 skavaycyymrgssylfmnsaseqslndlenaykldkqeetgrilkmnqdllkdetkvnkmfyklindeiiyavfsylpiysvmqvsstcrlwrhlaak 300
                 777777777777777777766666666666666666655555555555555555555555555555555555555555555555555555555555555 PP

                 E CS
       RAMPs 121 k 121
                  
  EFC36762.1 301 S 301
                 1 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.2     0.058   2.6e+02       3      32 ..      57      86 ..      55      87 .. 0.81
   2 ?    0.7   0.0      0.17   7.7e+02       5      23 ..      96     114 ..      94     117 .. 0.87
   3 ?    3.9   0.0     0.016        73       5      22 ..     174     191 ..     174     194 .. 0.91
   4 ?    3.1   0.3     0.029   1.3e+02       1      32 [.     206     238 ..     206     240 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.058
       TPR_2  3 alynlGlayyklgdyeeAleafekAleldP 32
                ++ +++ +  ++ + +eA++ +e Ale d+
  EFC36762.1 57 LYVQRAFLEVQAAHEKEAKRSMELALEMDE 86
                6777777777888889***********985 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.17
       TPR_2   5 ynlGlayyklgdyeeAlea 23 
                 y  +++++ + d+++A ++
  EFC36762.1  96 YLEACCHAIACDFDQATKL 114
                 77899**********9876 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.016
       TPR_2   5 ynlGlayyklgdyeeAle 22 
                 +n++ ++y++ +y+e+++
  EFC36762.1 174 FNIAVSLYNSCQYAECVK 191
                 799************976 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.029
       TPR_2   1 aealynlGlayyklgdy.eeAleafekAleldP 32 
                 a+++y++G +y+ ++   e+ l+++e A +ld 
  EFC36762.1 206 AYCYYMRGSSYLFMNSAsEQSLNDLENAYKLDK 238
                 6789*******9999999999999999999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (548 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 3301.82
//
Query:       EFC36763.1  [L=128]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.4e-06   28.4  70.4    0.00071   19.6  35.3    2.1  2  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6  35.3     4e-08   0.00071      55     110 ..       8      63 ..       1      64 [. 0.53
   2 !   16.1  36.0   4.5e-07    0.0081      59     112 ..      54     107 ..      53     113 .. 0.62

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 4e-08
  Trypan_PARP  55 ngtdpepepepepepepepepepepetepeeepepepepepepepepepepepepe 110
                    t+p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+
   EFC36763.1   8 TQTQPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPK 63 
                  34455555555555555555566555555555555555555555555555555555 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 4.5e-07
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepepg 112
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p 
   EFC36763.1  54 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPT 107
                  456666666666666666666666666666666666666666666666666664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      158  (0.00881254); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        38  (0.00211947); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.33s 00:00:01.13 Elapsed: 00:00:00.49
# Mc/sec: 784.68
//
Query:       EFC36764.1  [L=294]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.41   10.6   2.3         21    5.1   0.0    2.8  3  ApoO          Apolipoprotein O
        1.1    8.7  12.7        1.2    8.7   4.0    2.0  2  Exonuc_VII_L  Exonuclease VII, large subunit
        1.7    9.3   7.4    1.2e+02    3.3   7.4    2.7  1  DUF3800       Protein of unknown function (DUF3800)
        5.9    7.0   6.5        6.9    6.7   0.5    2.3  2  DUF1515       Protein of unknown function (DUF1515)
        7.5    7.4  19.8        1.3    9.8   6.8    3.6  4  RecG_N        RecG N-terminal helical domain
        7.7    6.8  13.3        1.1    9.4   1.4    3.0  3  FliJ          Flagellar FliJ protein
        9.4    6.2  30.0       0.56   10.2   1.7    4.2  4  Prefoldin_2   Prefoldin subunit


Domain annotation for each model (and alignments):
>> ApoO  Apolipoprotein O
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0         1   2.7e+03      39      61 ..      43      65 ..      37      76 .. 0.71
   2 ?    5.1   0.0    0.0081        21      33      68 ..     195     230 ..     188     232 .. 0.88
   3 ?    4.2   0.1     0.015        39      17      52 ..     251     286 ..     238     289 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1
        ApoO 39 nkvkskvetaeqsvtdtiasLke 61
                +++  k+e++ ++++++ ++Lk+
  EFC36764.1 43 SDIVAKIEEEIETFKKKKDELKN 65
                55666777777777777777765 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0081
        ApoO  33 avqdelnkvkskvetaeqsvtdtiasLkeppedllP 68 
                 + ++ l++v+++v++a q++ ++i +L +++e++l 
  EFC36764.1 195 QSSNFLRSVEDRVKQATQQLDSQIIELEKSREEILK 230
                 56778899***********************99986 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.015
        ApoO  17 eegvrslRkslepytsavqdelnkvkskvetaeqsv 52 
                  e v++  k le++t+ ++ + +k++ k+++ +q +
  EFC36764.1 251 LEMVETSKKVLEKQTTNCKLKAQKASAKIKDRVQRF 286
                 566788888888999999999999888888888876 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   1.4    0.0015       3.8     149     266 ..      38     168 ..      19     171 .. 0.67
   2 ?    8.7   4.0   0.00046       1.2     145     245 ..     167     275 ..     156     289 .. 0.60

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0015
  Exonuc_VII_L 149 leelerrlekaikrlleekkqrleklasrlkspeellerkrqrldeleerleralkkqlkkkrerleelkerlk......ekleekkerlkklkerl 239
                   +e+ ++ +  +i++ +e+ k++ ++l++ + ++e+ +++++  ++e e++ + ++  ++++++++++e  ++ k         e+++++++++ ++l
    EFC36764.1  38 IEKNKSDIVAKIEEEIETFKKKKDELKNIIVKKEKGVDDEELDFSESEDESSVQIIAEYHAEKKNINEECKKNKklknisPVAERQDAKIDEIGKQL 134
                   4566667777777788777888888877777777778777777777766666655555555555554444333124345445566667777777777 PP

  Exonuc_VII_L 240 elleekkerlee.......leeklealsplkvLk 266
                   ++ ++k++r++e       + +  +al+p+++L+
    EFC36764.1 135 AKETKKRKRVDEdfvceppILSAADALDPSNILN 168
                   7778888888867777777889999999999986 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00046
  Exonuc_VII_L 145 leeqleelerrlekaikrlleekkqrleklasrlkspeellerkrqrldeleerleralkkqlkkkrerleelkerlk........ekleekkerlk 233
                   l+e++++l +++ + ++  l++    +++ ++ l+s e+++++++q+ld+   +le++ ++ lk+  ++le lk + k        e +e+ k+ l+
    EFC36764.1 167 LNENVDSLLNEFCDLVDADLTKLDIGMTQSSNFLRSVEDRVKQATQQLDSQIIELEKSREEILKEFDNKLEALKFS-KtqtvgpylEMVETSKKVLE 262
                   5556666666666666666666666666667777888888888888888888888888888888888888888822.12355666544444444444 PP

  Exonuc_VII_L 234 klkerle.lleek 245
                   k++++ + +++++
    EFC36764.1 263 KQTTNCKlKAQKA 275
                   4444444222222 PP

>> DUF3800  Protein of unknown function (DUF3800)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   7.4     0.049   1.2e+02      29     109 ..      45      92 ..       8     292 .. 0.65

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.049
     DUF3800  29 eikkleekikelkkky...............krlleriakflkkndliksdeesdesilivldkkkkkekakkeleilldesvkfvdSkesrglQl 109
                  + k+ee+i+ +kkk                +                                                e++ f +S+++  +Q+
  EFC36764.1  45 IVAKIEEEIETFKKKKdelkniivkkekgvdD------------------------------------------------EELDFSESEDESSVQI 92 
                 33344444444444442222222222222220................................................4444444444444443 PP

>> DUF1515  Protein of unknown function (DUF1515)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.5    0.0027       6.9       3      77 ..      35     111 ..      33     119 .. 0.83
   2 ?    3.0   0.9     0.038        97       5      54 ..     206     259 ..     202     286 .. 0.66

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0027
     DUF1515   3 dagvlqqlgtllaevkelredlkrsedrsdasrakmyrkmd..elvervtalegsvvklkaditsvkevtedvkkwk 77 
                 d+ + ++  +++a+++e  e +k+ +d  + + +k  + +d  el    +  e+sv  + +  ++ k++ e+ kk k
  EFC36764.1  35 DGFIEKNKSDIVAKIEEEIETFKKKKDELKNIIVKKEKGVDdeELDFSESEDESSVQIIAEYHAEKKNINEECKKNK 111
                 6667788899*************9999999999999998864345555667799999999999**********9977 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.038
     DUF1515   5 gvlqqlgtllaevkel...red.lkrsedrsdasrakmyrkmdelvervtaleg 54 
                  v+q++++l +++ el   re+ lk+ +++ +a + + ++ +   +e v++ + 
  EFC36764.1 206 RVKQATQQLDSQIIELeksREEiLKEFDNKLEALKFSKTQTVGPYLEMVETSKK 259
                 578888888888777733355525678889999999999988877776665443 PP

>> RecG_N  RecG N-terminal helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   6.8   0.00049       1.3      10      82 ..      47     121 ..      38     125 .. 0.82
   2 ?    0.3   0.0      0.45   1.2e+03      13      58 ..     135     181 ..     127     192 .. 0.64
   3 ?    3.8   1.3     0.038        98      24      55 ..     201     232 ..     174     241 .. 0.64
   4 ?   -0.7   0.0      0.93   2.4e+03       5      20 ..     250     265 ..     246     290 .. 0.53

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00049
                 HHHHTS---TTT........HHHHHHH---GGGG-HHHH.HH.HHHHHHHHTTSSSS-HH.HHHHHHHHHHHHHH CS
      RecG_N  10 ekllkkvlsgkleteelieeikkkleliddplleneevlkek.lskfldYikpiasLpee.RkikRlknglemie 82 
                  k+ ++++  k++ +el + i kk + +dd++l+ +e+++e  ++ + +Y  + ++++ee +k k+lkn++ + e
  EFC36764.1  47 AKIEEEIETFKKKKDELKNIIVKKEKGVDDEELDFSESEDESsVQIIAEYHAEKKNINEEcKKNKKLKNISPVAE 121
                 455666666677778*******************99999875277788***********9556899999987666 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.45
                 HTS---TTT..........HHHHHHH---GGGG-HHHH.HHHHHHHHH CS
      RecG_N  13 lkkvlsgkleteeliee..ikkkleliddplleneevlkeklskfldY 58 
                 +k+ ++ k+  e+ + e  i + ++++d + + ne+v    l++f+d 
  EFC36764.1 135 AKETKKRKRVDEDFVCEppILSAADALDPSNILNENVD-SLLNEFCDL 181
                 44444444433444433337777888888888888888.888888875 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.038
                 ......HHHHHHH---GGGG-HHHH.HHHHHH CS
      RecG_N  24 eelieeikkkleliddplleneevlkeklskf 55 
                   + + +k+  +++d +++e e++ +e l++f
  EFC36764.1 201 RSVEDRVKQATQQLDSQIIELEKSREEILKEF 232
                 44556677777889999999999998888888 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.93
                 HHHHHHHHHTS---TT CS
      RecG_N   5 FLeelekllkkvlsgk 20 
                 +Le +e+++k  +++ 
  EFC36764.1 250 YLEMVETSKKVLEKQT 265
                 6666666554443322 PP

>> FliJ  Flagellar FliJ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.9     0.048   1.2e+02      30      79 ..      95     145 ..      76     149 .. 0.65
   2 ?    9.4   1.4   0.00045       1.1      49      85 ..     195     231 ..     190     246 .. 0.85
   3 ?    7.0   3.8    0.0025       6.5      10      85 ..     207     282 ..     205     285 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.048
        FliJ  30 eyqkqlsgea.qglsaaelrnyqafisaldeaiaqqkqelaqaekqvekar 79 
                 ey+ ++++   +  +  +l+n++   ++ d +i+++ ++la+ +k++++  
  EFC36764.1  95 EYHAEKKNINeECKKNKKLKNISPVAERQDAKIDEIGKQLAKETKKRKRVD 145
                 333333332222346678888888899999999999999988888877665 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00045
        FliJ  49 nyqafisaldeaiaqqkqelaqaekqvekareewqea 85 
                 + ++f+++++++++q++q+l+ +  ++ek+ree +++
  EFC36764.1 195 QSSNFLRSVEDRVKQATQQLDSQIIELEKSREEILKE 231
                 6789***************************998775 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0025
        FliJ  10 aqrelqqaeekleeleqyrqeyqkqlsgeaqglsaaelrnyqafisaldeaiaqqkqelaqaekqvekareewqea 85 
                 ++++ qq  +++ ele+ r+e  k++ ++ ++l+ ++ +++  +++ +++  + ++++ ++ + + +ka ++ +  
  EFC36764.1 207 VKQATQQLDSQIIELEKSREEILKEFDNKLEALKFSKTQTVGPYLEMVETSKKVLEKQTTNCKLKAQKASAKIKDR 282
                 6788999****************************************************99999999998877665 PP

>> Prefoldin_2  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   1.7   0.00022      0.56      40      92 ..      22      74 ..      13      78 .. 0.92
   2 ?    1.7   1.7     0.093   2.4e+02      14      59 ..      93     138 ..      87     146 .. 0.65
   3 ?    7.3   3.4    0.0018       4.5      30      99 ..     170     239 ..     166     245 .. 0.79
   4 ?    3.6   1.4     0.024        61      59      93 ..     246     280 ..     241     285 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00022
                 HS-TT--EEEEETTEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2 40 lldedtkvyklvGdvlvkqdkeevkeeLeerketlekeiktlekqleklekel 92
                 +++ed+k +    d +++++k ++ ++ ee++et +k+ ++l++ + k+ek +
   EFC36764.1 22 TVPEDNKFFVELFDGFIEKNKSDIVAKIEEEIETFKKKKDELKNIIVKKEKGV 74
                 6899999999999***********************************99976 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.093
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHS-TT.--EEEEETTEEEEE- CS
  Prefoldin_2  14 lqqlaqqikqletqlkelelvleelellded.tkvyklvGdvlvkqd 59 
                  + ++++++k++++++k++++ ++ ++ ++e  +     +G+ l k++
   EFC36764.1  93 IAEYHAEKKNINEECKKNKKLKN-ISPVAERqDAKIDEIGKQLAKET 138
                  56778888888888888888654.55555443445555665555555 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0018
                  HHHHHHHHHHHS-TT--EEEEETTEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2  30 elelvleelelldedtkvyklvGdvlvkqdkeevkeeLeerketlekeiktlekqleklekeleelkeel 99 
                  ++++ l+e+ +l + +     +G +  ++ + +v++++++   +l+ +i +lek+ e++ ke+++  e l
   EFC36764.1 170 NVDSLLNEFCDLVDADLTKLDIGMTQSSNFLRSVEDRVKQATQQLDSQIIELEKSREEILKEFDNKLEAL 239
                  5566666666666665666677777777778899****************************99876665 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.024
                  -HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2  59 dkeevkeeLeerketlekeiktlekqleklekele 93 
                  ++   +e++e++k+ lek+ ++++ + +k  ++++
   EFC36764.1 246 TVGPYLEMVETSKKVLEKQTTNCKLKAQKASAKIK 280
                  55566788889999999998888888888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (294 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2557  (0.142618); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.73u 0.36s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 1685.48
//
Query:       EFC36765.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.071   12.9   2.9       0.12   12.1   2.9    1.3  1  PBC       PBC domain


Domain annotation for each model (and alignments):
>> PBC  PBC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   2.9   6.7e-06      0.12     100     159 ..       3      62 ..       1      72 [. 0.89

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 6.7e-06
         PBC 100 nsieqsdyrakLaqirqiyeeelekyeqackeFtehvrnllreqsetRPisekeiermvs 159
                 n+ +++ y++kLa+i +++ ++ e y+ +    +e+v +l+ +q++ R +s+++++ + +
  EFC36765.1   3 NNQNNNQYKRKLANIEEEHIANEEVYQDEDLWCSEEVDQLVFNQTKKRKVSNESLDEIEE 62 
                 6778999*******************999888899******************9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       823  (0.0459033); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 2408.24
//
Query:       EFC36766.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00012   22.4  18.8     0.0025   18.2   0.9    5.8  6  LRR_4       Leucine Rich repeats (2 copies)
     0.0003   20.5   2.4     0.0003   20.5   2.4    3.6  5  LRR_8       Leucine rich repeat
  ------ inclusion threshold ------
      0.053   13.4   0.0       0.19   11.6   0.0    1.9  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.3      0.18   1.1e+03       2      10 ..      12      20 ..      11      46 .. 0.62
   2 ?    0.5   0.0      0.15   9.2e+02      20      32 ..     138     156 ..     132     166 .. 0.64
   3 !    8.5   0.5   0.00047       2.8      17      35 ..     175     192 ..     168     202 .. 0.76
   4 !   18.2   0.9   4.2e-07    0.0025       1      29 [.     205     234 ..     205     248 .. 0.83
   5 ?    2.6   0.0     0.034   2.1e+02      15      33 ..     241     258 ..     236     268 .. 0.73
   6 ?    2.1   0.2     0.048   2.9e+02       1      29 [.     250     280 ..     250     309 .. 0.64

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.18
                S--EEE--S CS
       LRR_4  2 nLevLdLsn 10
                +L++L Ls+
  EFC36766.1 12 KLKKLKLSQ 20
                455555543 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.15
                 H.....H.-TT--EEE-.- CS
       LRR_4  20 e.....k.lpnLkeLdLsg 32 
                 e     + + nLk+L++ +
  EFC36766.1 138 EqsnksGcFRNLKKLHVYF 156
                 4444554488999998844 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00047
                 S-HHH-TT--EEE-.-S-- CS
       LRR_4  17 plleklpnLkeLdLsgNnl 35 
                 +++++l++L++L+L  N l
  EFC36766.1 175 EWFSNLKDLESLNL-KNAL 192
                 35899*********.8844 PP

  == domain 4  score: 18.2 bits;  conditional E-value: 4.2e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLd 29 
                 +nL++L +s+N+l  i+   +  l+nL++L 
  EFC36766.1 205 KNLRHLTCSGNNLAQIDAniPI-LTNLESLA 234
                 79****************9888.******95 PP

  == domain 5  score: 2.6 bits;  conditional E-value: 0.034
                 E-S-.HHH-TT--EEE-.-S CS
       LRR_4  15 dipl.leklpnLkeLdLsgN 33 
                 di+  ++k pnLk+L + +N
  EFC36766.1 241 DISAfFSKVPNLKKL-V-FN 258
                 344437789999999.4.34 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.048
                 SS--EEE--SS-...--E-S-HHH-TT--EEE CS
       LRR_4   1 pnLevLdLsnNq...ltdiplleklpnLkeLd 29 
                 pnL++L +++     +t i+  ++++ Lke++
  EFC36766.1 250 PNLKKLVFND-YyevMTFIEIRNNCKLLKEFH 280
                 6788888884.223355777777788888776 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.26   1.5e+03      25      34 ..      11      20 ..       5      29 .. 0.75
   2 ?   -2.3   0.0      0.67     4e+03      20      27 ..     145     152 ..     142     154 .. 0.49
   3 !   20.5   2.4   5.1e-08    0.0003      15      61 .]     171     217 ..     164     217 .. 0.94
   4 ?    0.2   0.0      0.11   6.5e+02      20      32 ..     245     257 ..     241     259 .. 0.79
   5 ?   -3.5   0.0       1.6   9.5e+03      23      33 ..     296     306 ..     292     307 .. 0.55

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.26
                TT--EEE--S CS
       LRR_8 25 snLkvLdLsn 34
                ++Lk L+Ls+
  EFC36766.1 11 PKLKKLKLSQ 20
                5666666664 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.67
                 SSTT-TT- CS
       LRR_8  20 aFkglsnL 27 
                 +F++l++L
  EFC36766.1 145 CFRNLKKL 152
                 44444444 PP

  == domain 3  score: 20.5 bits;  conditional E-value: 5.1e-08
                 EE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  15 slddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++ +e+F++l+ L++L+L+n l +++ +  +  +++Lr+L+ sgN+L
  EFC36766.1 171 KILQEWFSNLKDLESLNLKNALPQSVMNTILKECKNLRHLTCSGNNL 217
                 5679*****************************************98 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.11
                 SSTT-TT--EEE- CS
       LRR_8  20 aFkglsnLkvLdL 32 
                 +F++++nLk L  
  EFC36766.1 245 FFSKVPNLKKLVF 257
                 6888999999976 PP

  == domain 5  score: -3.5 bits;  conditional E-value: 1.6
                 T-TT--EEE-- CS
       LRR_8  23 glsnLkvLdLs 33 
                 ++++L+ +++s
  EFC36766.1 296 QMNQLERISIS 306
                 45556666555 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   3.2e-05      0.19       7      34 ..      31      60 ..      30      67 .. 0.89
   2 ?   -3.1   0.0       1.3   7.6e+03       4      14 ..     192     202 ..     190     213 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 3.2e-05
  F-box-like  7 EiLlqIFsyL.ppsdLlr.lalVCrrWrrv 34
                EiL  IF yL p +dLl+ ++ V+ +++ +
  EFC36766.1 31 EILANIFVYLdPITDLLPnVMPVSEKFYHA 60
                9*********6677***999****999975 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.3
  F-box-like   4 LPdEiLlqIFs 14 
                 LP  ++ +I+ 
  EFC36766.1 192 LPQSVMNTILK 202
                 88888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       524  (0.0292264); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2158.12
//
Query:       EFC36767.1  [L=927]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      9e-38  127.5  56.1    1.3e-10   40.7   7.3   11.0  9  Pentapeptide    Pentapeptide repeats (8 copies)
    1.3e-36  124.6  73.7    2.4e-12   46.8   5.8    6.9  7  Pentapeptide_4  Pentapeptide repeats (9 copies)
    3.3e-20   72.7   3.6    3.3e-20   72.7   3.6    2.8  3  TLD             TLD
    4.8e-20   71.5  62.8    3.1e-07   30.4   2.8   10.1 10  Pentapeptide_3  Pentapeptide repeats (9 copies)
    7.9e-05   22.8   0.4     0.0003   21.0   0.0    2.2  2  BTB             BTB/POZ domain
     0.0018   18.5   9.1     0.0018   18.5   9.1    3.2  3  zf-RING_2       Ring finger domain
      0.006   16.9   0.0      0.026   14.9   0.0    2.2  1  BTB_2           BTB/POZ domain
  ------ inclusion threshold ------
      0.022   15.3   9.9      0.075   13.6   9.9    1.9  1  V-ATPase_G      Vacuolar (H+)-ATPase G subunit
      0.068   12.7   6.4       0.14   11.7   6.4    1.4  1  Exonuc_VII_L    Exonuclease VII, large subunit
       0.51   10.6  10.7       0.13   12.5   5.7    2.7  2  zf-C3HC4_4      zinc finger of C3HC4-type, RING
       0.57   10.1  16.3        0.1   12.4   9.8    3.1  2  zf-C3HC4_2      Zinc finger, C3HC4 type (RING finger)
       0.67   10.0  10.8       0.14   12.3   6.3    2.4  1  zf-RING_UBOX    RING-type zinc-finger
       0.74    9.9   7.2         10    6.2   0.2    3.9  2  zf-BED          BED zinc finger
        2.4    8.1  19.3        1.9    8.5   0.1    4.8  5  CfAFP           Choristoneura fumiferana antifreeze protein (
        5.9    7.1  13.9         14    5.9  11.7    2.8  3  zf-RING_10      zinc RING finger of MSL2
          7    7.0  19.6         16    5.8  19.6    1.5  1  OmpH            Outer membrane protein (OmpH-like)


Domain annotation for each model (and alignments):
>> Pentapeptide  Pentapeptide repeats (8 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.1   2.6e-07   0.00029       2      40 .]     355     393 ..     352     393 .. 0.97
   2 !   40.7   7.3   1.1e-13   1.3e-10       2      40 .]     385     423 ..     385     423 .. 0.98
   3 !   15.6   0.0   8.4e-06    0.0094       1      36 [.     424     459 ..     424     460 .. 0.93
   4 !   29.6   7.7   3.4e-10   3.9e-07       1      40 []     485     524 ..     485     524 .. 0.98
   5 ?    2.0   0.0      0.14   1.6e+02      11      25 ..     526     540 ..     524     542 .. 0.49
   6 !   21.9   0.5   8.7e-08   9.7e-05       2      34 ..     548     580 ..     547     580 .. 0.96
   7 !   12.1   0.9   0.00011      0.12      11      38 ..     603     630 ..     590     631 .. 0.85
   8 !    8.9   0.0     0.001       1.1       3      23 ..     644     664 ..     643     665 .. 0.53
   9 !    8.1   1.5    0.0019       2.1      13      34 ..     666     687 ..     663     690 .. 0.63

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 2.6e-07
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   nLsg +L+    +++nl+ +  +g+++sg +L+++n++g
    EFC36767.1 355 NLSGLDLRKLVINNTNLEKSEIIGSDFSGMNLKQTNFKG 393
                   89999********************************98 PP

  == domain 2  score: 40.7 bits;  conditional E-value: 1.1e-13
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   nL+++n+ g+nL+g+n+s+++Lt++nl+ + L ++n+s+
    EFC36767.1 385 NLKQTNFKGSNLRGCNFSNCDLTSVNLQECELDDCNFSN 423
                   89***********************************97 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 8.4e-06
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCE CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsga 36 
                   A+L  +n+s ++L + nls+A   ++ ++gA+++++
    EFC36767.1 424 AILGKTNFSKSSLLNINLSNAIYKETKFIGAKFENV 459
                   678889***************************997 PP

  == domain 4  score: 29.6 bits;  conditional E-value: 3.4e-10
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   ++Ls+ n++++n  ++nl+ + L+++n++++++ ++++++
    EFC36767.1 485 SDLSNSNFTNCNAIDCNLESTILRKTNFEKSQFDNCRFNN 524
                   69************************************97 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.14
                   SCCEECCCESEEECT CS
  Pentapeptide  11 anLsganlsgAnLtg 25 
                   +++++++++++++ +
    EFC36767.1 526 CKFEETSFKNSSMKN 540
                   455555555555444 PP

  == domain 6  score: 21.9 bits;  conditional E-value: 8.7e-08
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EEC CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLs 34 
                   +L +++Ls+++L++++++ +   ++n+ +++++
    EFC36767.1 548 DLVRVDLSNCKLTKTDFTVSYIFETNFLNCNFC 580
                   799****************************95 PP

  == domain 7  score: 12.1 bits;  conditional E-value: 0.00011
                   SCCEECCCESEEECT-B-TT-EECCEEE CS
  Pentapeptide  11 anLsganlsgAnLtgAnlsgAdLsganL 38 
                    +++g  +++ ++t++n+++++++++ +
    EFC36767.1 603 GDFTGFKFENVKFTNTNIEKSKFENSTF 630
                   4789999999999999999999999887 PP

  == domain 8  score: 8.9 bits;  conditional E-value: 0.001
                   -TT-B-CCSCCEECCCESEEE CS
  Pentapeptide   3 LsgAnLsganLsganlsgAnL 23 
                   L+ +n  +++++g+ +++ ++
    EFC36767.1 644 LQHCNVIECDFNGSIFEEIDF 664
                   555555555555555555555 PP

  == domain 9  score: 8.1 bits;  conditional E-value: 0.0019
                   CEECCCESEEECT-B-TT-EEC CS
  Pentapeptide  13 LsganlsgAnLtgAnlsgAdLs 34 
                   L +anl+  +++++ + +AdL+
    EFC36767.1 666 LIQANLETNSFNNCVFKNADLR 687
                   5566666666666666666665 PP

>> Pentapeptide_4  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   0.3   6.1e-09   6.9e-06      11      69 ..     344     402 ..     337     403 .. 0.90
   2 !   46.8   5.8   2.1e-15   2.4e-12       3      77 .]     396     472 ..     395     472 .. 0.93
   3 !   23.3   4.7   4.8e-08   5.4e-05      13      69 ..     436     493 ..     434     498 .. 0.66
   4 !   26.6  16.1   4.5e-09     5e-06       1      66 [.     475     541 ..     461     542 .. 0.62
   5 !   13.6   3.6     5e-05     0.055       3      44 ..     549     597 ..     547     602 .. 0.81
   6 !   27.8   9.4   1.9e-09   2.2e-06       2      64 ..     604     665 ..     603     674 .. 0.85
   7 !   15.6   6.7   1.2e-05     0.013      15      65 ..     668     727 ..     665     739 .. 0.68

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 6.1e-09
  Pentapeptide_4  11 cklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfs 69 
                     ++l++ + s+ +l + +++   ++n+n++++ +  +df++++lk ++F+g+nl+++nfs
      EFC36767.1 344 VNLTRSQKSALNLSGLDLRKLVINNTNLEKSEIIGSDFSGMNLKQTNFKGSNLRGCNFS 402
                     56666677788999999999999***********************************7 PP

  == domain 2  score: 46.8 bits;  conditional E-value: 2.1e-15
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvn.fsd.klkdidF 77 
                     ++ c f nc+l+ vn+ e++l dcnF+++ l  +nF++++l +++++++ +k++ F g  ++nv+ f + kl ++dF
      EFC36767.1 396 LRGCNFSNCDLTSVNLQECELDDCNFSNAILGKTNFSKSSLLNINLSNAIYKETKFIGAKFENVTgFQNrKLGSLDF 472
                     678***********************************************************875385449999887 PP

  == domain 3  score: 23.3 bits;  conditional E-value: 4.8e-08
  Pentapeptide_4  13 lsnvnFsearlrdcnFtecrlsnvn.FdecnlsdvdfaevdlkrasFsgcnlknvnfs 69 
                     l n+n+s+a  +++ F ++++ nv+ F++ +l ++df++ ++k+++F +++l+n+nf 
      EFC36767.1 436 LLNINLSNAIYKETKFIGAKFENVTgFQNRKLGSLDFSNSSFKSIEFCNSDLSNSNFT 493
                     5566666666677777777775544477777777777777777777777777777774 PP

  == domain 4  score: 26.6 bits;  conditional E-value: 4.5e-09
  Pentapeptide_4   1 aeftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfa.evdlkrasFsgcnlknv 66 
                     ++f++  f n++lsn nF++++ +dcn++++ l  +nF+++++++++f+ ++++ ++sF+++  knv
      EFC36767.1 475 SSFKSIEFCNSDLSNSNFTNCNAIDCNLESTILRKTNFEKSQFDNCRFNnKCKFEETSFKNSSMKNV 541
                     3455556666666666666666666666666666666666666666664246666666666666654 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 5e-05
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrl.......snvnFdecnls 44 
                     + r+ + nckl++++F+ +++ ++nF +c++       ++   ++c+ls
      EFC36767.1 549 LVRVDLSNCKLTKTDFTVSYIFETNFLNCNFcmevlrsKHNIISNCDLS 597
                     668999*************************976666555556666654 PP

  == domain 6  score: 27.8 bits;  conditional E-value: 1.9e-09
  Pentapeptide_4   2 eftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlk 64 
                     +ft  +f+n+k++n+n +++++++++F+ c++ ++nF++ +l+++++ e+d++ + F++ +++
      EFC36767.1 604 DFTGFKFENVKFTNTNIEKSKFENSTFVKCKI-QMNFKKDSLQHCNVIECDFNGSIFEEIDFT 665
                     79999**************************9.578888888888888888888888887776 PP

  == domain 7  score: 15.6 bits;  conditional E-value: 1.2e-05
  Pentapeptide_4  15 nvnFsearlrdcnFtecrl.........snvnFdecnlsdvdfaevdlkrasFsgcnlkn 65 
                     ++n++++ +++c F++++l            +Fd c+++  +f++ ++ ++ F++ nl++
      EFC36767.1 668 QANLETNSFNNCVFKNADLrelkdlskfLGSTFDACLFNFKEFTNKHIQKIHFQNINLQD 727
                     667777777777777777755544444444448888888888888888888888888775 PP

>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.2       3.4   3.8e+03     102     117 ..     510     535 ..     478     546 .. 0.59
   2 ?   -3.4   0.1         9     1e+04     112     122 ..     618     632 ..     595     652 .. 0.51
   3 !   72.7   3.6     3e-23   3.3e-20       1     138 [.     775     925 ..     775     926 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3.4
         TLD 102 sslekgtsrhs..........etfen 117
                 +++ek+++ ++          ++f+n
  EFC36767.1 510 TNFEKSQFDNCrfnnkckfeeTSFKN 535
                 34444444444333334555555554 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 9
         TLD 112 s....etfengllsg 122
                 +    + fen+ + +
  EFC36767.1 618 TniekSKFENSTFVK 632
                 133333333333332 PP

  == domain 3  score: 72.7 bits;  conditional E-value: 3e-23
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl.....spkfkvykstgknkaylntssdglgfGggqp 94 
                 lly+ s+dg++++ +++k++n+gptl++ik+e+++ifG+f+s++w+s++ +++ ds+ f+f++     s +f+ +k + +++a+l+++ +   fG    
  EFC36767.1 775 LLYRGSRDGFKAEHFHSKCDNQGPTLTIIKSEHNQIFGGFTSKSWRSRSGECVTDSSAFIFKItdsngSYQFEHFKIQREENAILVNQYYLALFGA--- 870
                 69******************************************************************99*******************8889996... PP

         TLD  95 kfsLwidsslekgtsrhs.........etfengllsg.........aseerfkikdiEVWgl 138
                   ++ i+s+++ ++ + s         + ++     +         a++  fk+++iEV+++
  EFC36767.1 871 --DIQIESDCNLNYRSRSnlgsyyelpKGYQ-----KgsneannylAGSYYFKVSEIEVFKI 925
                 ..67777777766666555664444444444.....35555699999*************87 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   0.7   2.5e-08   2.8e-05       2      46 ..     367     408 ..     366     410 .. 0.94
   2 !   30.4   2.8   2.8e-10   3.1e-07       1      48 []     381     425 ..     381     425 .. 0.97
   3 !   25.0   4.1   1.4e-08   1.5e-05       1      47 [.     391     434 ..     391     460 .. 0.95
   4 !    9.4   8.1     0.001       1.1      18      48 .]     468     496 ..     426     506 .. 0.70
   5 !   16.7   9.8   5.4e-06     0.006       2      47 ..     488     531 ..     484     542 .. 0.87
   6 ?    2.7   0.2      0.13   1.4e+02       6      28 ..     554     579 ..     549     598 .. 0.59
   7 !   11.6   3.3   0.00022      0.25       6      38 ..     600     630 ..     599     633 .. 0.86
   8 !   13.5   0.2   5.4e-05     0.061       4      33 ..     637     664 ..     636     666 .. 0.91
   9 ?    5.9   0.2     0.013        15      20      34 ..     674     687 ..     665     690 .. 0.63
  10 ?    5.7   3.6     0.014        16       1      29 [.     676     706 ..     676     729 .. 0.78

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 2.5e-08
  Pentapeptide_3   2 sganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsg 46 
                     +++n++++    g+ Fsg+ + ++++F +++++g++F+ ++d++ 
      EFC36767.1 367 NNTNLEKS-EIIGSDFSGM-NLKQTNFKGSNLRGCNFS-NCDLTS 408
                     799*****.**********.9****************9.***976 PP

  == domain 2  score: 30.4 bits;  conditional E-value: 2.8e-10
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsgat 48 
                     Fsg n++++ +F g++ +g+ +Fsn+d++s++++++  + d++Fs+a+
      EFC36767.1 381 FSGMNLKQT-NFKGSNLRGC-NFSNCDLTSVNLQECELD-DCNFSNAI 425
                     99*******.**********.9****************9.*****985 PP

  == domain 3  score: 25.0 bits;  conditional E-value: 1.4e-08
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsga 47 
                     F+g+n++g+ +F+++  ++  + +++ +++++Fs+a+    ++Fs +
      EFC36767.1 391 FKGSNLRGC-NFSNCDLTSV-NLQECELDDCNFSNAILG-KTNFSKS 434
                     999******.**********.9***************95.9999987 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.001
  Pentapeptide_3  18 sgaasFsnadFgsadFsgarFtgdvdFsgat 48 
                      +  +Fsn+ F s+ F+++  + +++F++++
      EFC36767.1 468 GSL-DFSNSSFKSIEFCNSDLS-NSNFTNCN 496
                     222.588888888888888887.88888874 PP

  == domain 5  score: 16.7 bits;  conditional E-value: 5.4e-06
  Pentapeptide_3   2 sganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsga 47 
                     s++nF+++ +  +++ +++   + ++F+ + F+++rF+  + F+++
      EFC36767.1 488 SNSNFTNC-NAIDCNLEST-ILRKTNFEKSQFDNCRFNNKCKFEET 531
                     78999999.9999999999.59999999999999999966999987 PP

  == domain 6  score: 2.7 bits;  conditional E-value: 0.13
  Pentapeptide_3   6 FsgaadFrgatFsgaa....sFsnadF 28 
                     +s++  ++++ F+ +     +F n++F
      EFC36767.1 554 LSNC-KLTKTDFTVSYifetNFLNCNF 579
                     4445.5555555555332223444444 PP

  == domain 7  score: 11.6 bits;  conditional E-value: 0.00022
  Pentapeptide_3   6 FsgaadFrgatFsgaasFsnadFgsadFsgarF 38 
                     F +  dF+g  F++   F+n++++ + F++++F
      EFC36767.1 600 FLNG-DFTGFKFENV-KFTNTNIEKSKFENSTF 630
                     7788.9999999999.79999999999999999 PP

  == domain 8  score: 13.5 bits;  conditional E-value: 5.4e-05
  Pentapeptide_3   4 anFsgaadFrgatFsgaasFsnadFgsadF 33 
                      nF+++ ++ +++ + + +F+++ F+++dF
      EFC36767.1 637 MNFKKD-SLQHCNVIEC-DFNGSIFEEIDF 664
                     58999*.**********.********9999 PP

  == domain 9  score: 5.9 bits;  conditional E-value: 0.013
  Pentapeptide_3  20 aasFsnadFgsadFs 34 
                       sF+n++F +ad++
      EFC36767.1 674 N-SFNNCVFKNADLR 687
                     3.6667777666665 PP

  == domain 10  score: 5.7 bits;  conditional E-value: 0.014
  Pentapeptide_3   1 FsganFsgaadFr....gatFsgaasFsnadFg 29 
                     F++++F++a d+r     + F g++ F+ + F+
      EFC36767.1 676 FNNCVFKNA-DLRelkdLSKFLGST-FDACLFN 706
                     899999999.999999967777774.7666664 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   2.7e-07    0.0003      36     109 ..     247     325 ..     244     327 .. 0.81
   2 ?   -2.5   0.1       5.5   6.1e+03      44      63 ..     707     727 ..     698     730 .. 0.54

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 2.7e-07
                 HHHHHHTST......TTTTCCCE..EEEETTSGHHHHHHHHHHH.HHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHHHHHHHH CS
         BTB  36 yFkalftsk......eieessvs..eielddvepeafealLefi.YtgeleitseenleelLaaadllqiprlkkaceeflkq 109
                  Fk++ft++      + +++      i+  d++p++f+ ++e++ Y +  e+ s ++  ++L+a +++ + ++ + ++e + +
  EFC36767.1 247 LFKKMFTGQhpcyqtP-SKQ--FddSIYFIDCDPNVFKHMIEWLqYGEIAEL-SNDMRRSVLNACKKFGLTNMSNDLSESINK 325
                 7********9986532.222..1458******************66666666.699999*************99999988766 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 5.5
                 T.TTTTCCCEEEEETTSGHHH CS
         BTB  44 k.eieessvseielddvepea 63 
                   e+++++ ++i+ ++++ ++
  EFC36767.1 707 FkEFTNKHIQKIHFQNINLQD 727
                 335555555556666555554 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   9.1   1.6e-06    0.0018       3      44 .]      44      81 ..      42      81 .. 0.88
   2 ?   -3.1   0.1       9.5   1.1e+04      21      28 ..     106     111 ..      98     128 .. 0.45
   3 ?   -0.3   0.5       1.3   1.4e+03       2      21 ..     576     594 ..     575     597 .. 0.78

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.6e-06
   zf-RING_2  3 CpICleelssadsvlllpCgHvfhreClerwlrssstCPlCr 44
                C+ICl ++ ++ s   + Cg +f+ +C+e+     s CP+Cr
  EFC36767.1 44 CSICLLPFVDPISHNSDACGNTFCLKCVEK----VSDCPMCR 81
                ********9888877889*********766....578****9 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 9.5
   zf-RING_2  21 CgHvfhre 28 
                 Cg  ++++
  EFC36767.1 106 CG--MCKN 111
                 33..2333 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 1.3
   zf-RING_2   2 eCpICleelssadsvlllpC 21 
                 +C  C+e l s+++++   C
  EFC36767.1 576 NCNFCMEVLRSKHNIISN-C 594
                 6999*9999887777755.7 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   2.3e-05     0.026       1      86 [.     221     312 ..     221     319 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.3e-05
                 EEEEETTEEEEEEHHHH...HTSTTSTTTSSGG........GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-B---TTS-HHHHHHHHHHHT- CS
       BTB_2   1 vklnVgGtrfetskstL...srkpdtlLgkllkte....elddydeetneyffDRspklFetiLnyyrtggkLhrpeevelkslleElefygl 86 
                 +++nV Gt++ +s       +r  d l++k+ + +    ++ +++ +++ yf+D +p++F++ +++++  g++ + ++   +s+l+  + +gl
  EFC36767.1 221 IHINVRGTIMTVSLGDFihnERESDNLFKKMFTGQhpcyQTPSKQFDDSIYFIDCDPNVFKHMIEWLQY-GEIAELSNDMRRSVLNACKKFGL 312
                 56888888888776544222345788999999988777557777888899*******************.88777766666666666555555 PP

>> V-ATPase_G  Vacuolar (H+)-ATPase G subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   9.9   6.7e-05     0.075      36      96 ..     129     189 ..     124     220 .. 0.96

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 6.7e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHSSHHHHHHHHHHHHHHHHHHHH CS
  V-ATPase_G  36 eeAekEieeyrakkekefkekeaeklgseeelekkieketeekikelkesvkknkeavvke 96 
                 +eA + +ee+++k e+ef++k ++   ++eel + +++e e++++e ke+++k +e+ +++
  EFC36767.1 129 HEAYQQVEEFKKKLEQEFQQKSEKLQREHEELIEIVKAEMEQHLREAKENLAKLEENLLQQ 189
                 59****************************************************9999987 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   6.4   0.00012      0.14     144     227 ..     130     216 ..      92     254 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00012
  Exonuc_VII_L 144 eleeqleelerrlekaikrlleekkqrleklasrlk.speellerkrqrldeleerleralkkqlkkkrerleelkerl.k.eklee 227
                   e  +q+ee++++le++++++ e+ +++ e+l + +k + e+ l++++++l +lee+l ++ kk+ +  +++++e ++r+ + ekle+
    EFC36767.1 130 EAYQQVEEFKKKLEQEFQQKSEKLQREHEELIEIVKaEMEQHLREAKENLAKLEENLLQQFKKKEELLESNMKERESRIlTrEKLEN 216
                   445666666666666666666666666666666665566666666666666666666666555544444444444444432233333 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   5.7   0.00011      0.13       1      29 [.      44      75 ..      44      83 .. 0.88
   2 ?   -2.4   0.2       4.9   5.5e+03      18      23 ..     577     582 ..     575     588 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00011
  zf-C3HC4_4  1 CPiCldYLekPvsle...CGhsfClsCisslq 29
                C iCl  + +P+s +   CG +fCl+C+++++
  EFC36767.1 44 CSICLLPFVDPISHNsdaCGNTFCLKCVEKVS 75
                99**********986666**********9986 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 4.9
  zf-C3HC4_4  18 hsfCls 23 
                 ++fC++
  EFC36767.1 577 CNFCME 582
                 678876 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   9.8   9.2e-05       0.1       2      40 .]      44      80 ..      43      80 .. 0.94
   2 ?   -0.6   0.5       1.1   1.2e+03       2      12 ..     577     587 ..     576     595 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 9.2e-05
  zf-C3HC4_2  2 CpiCldmlkdpsvvt..pCgHvfCqkCilrsLeekneCPlC 40
                C iCl  + dp+  +  +Cg +fC kC+ +     + CP+C
  EFC36767.1 44 CSICLLPFVDPISHNsdACGNTFCLKCVEKV----SDCPMC 80
                ***********888788*************7....8***** PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.1
  zf-C3HC4_2   2 CpiCldmlkdp 12 
                 C  C+++l   
  EFC36767.1 577 CNFCMEVLRSK 587
                 99****99864 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   6.3   0.00012      0.14       1      26 [.      44      72 ..      44     107 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00012
  zf-RING_UBOX  1 CpIClelftdPlvlp....CGHtFCreClw 26
                  C+ICl +f dP + +    CG tFC +C++
    EFC36767.1 44 CSICLLPFVDP-ISHnsdaCGNTFCLKCVE 72
                  ***********.5223567*********92 PP

>> zf-BED  BED zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.3     0.018        20      12      43 ..      99     126 ..      90     127 .. 0.77
   2 ?    6.2   0.2    0.0092        10      15      32 ..     573     590 ..     568     593 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.018
                 GGSS--EETTTTEE----SSTHHHHHHHHHS- CS
      zf-BED  12 lkeqkavCryCgkilsrgggttnLkrHLrrkH 43 
                 l++ k++C  C++i  rg     Lk H ++++
  EFC36767.1  99 LDKLKVKCGMCKNIVLRG----ELKVHQEKYC 126
                 5799**********9998....6666655555 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0092
                 S--EETTTTEE----SST CS
      zf-BED  15 qkavCryCgkilsrgggt 32 
                 ++  C++C+++l +++++
  EFC36767.1 573 NFLNCNFCMEVLRSKHNI 590
                 6788*********99775 PP

>> CfAFP  Choristoneura fumiferana antifreeze protein (CfAFP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.1    0.0017       1.9      52     118 ..     344     408 ..     313     424 .. 0.80
   2 ?    0.8   0.0       0.4   4.5e+02      40      93 ..     407     460 ..     405     468 .. 0.75
   3 ?    4.2   4.0     0.035        39      30      68 ..     483     521 ..     467     543 .. 0.57
   4 ?   -1.5   0.1       2.1   2.4e+03      40      74 ..     543     579 ..     529     602 .. 0.68
   5 ?    2.9   0.4     0.087        98      36      78 ..     612     653 ..     601     675 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0017
       CfAFP  52 sictrsqysdayvkksvttdcnidksqlygttctgsrydGvyitsstttgtrisGpgcsissctitr 118
                    trsq s  ++      +  i++++l  +   gs + G+ ++ +   g+++ G  c+ s+c +t 
  EFC36767.1 344 VNLTRSQKSALNLSGLDLRKLVINNTNLEKSEIIGSDFSGMNLKQTNFKGSNLRG--CNFSNCDLTS 408
                 5579999999999999999999**********************99999999875..******9995 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.4
       CfAFP  40 tncyidnselessictrsqysdayvkksvttdcnidksqlygttctgsrydGvy 93 
                 t  ++++ el+ +  + +   +++  ks   ++n++++    t   g++++ v+
  EFC36767.1 407 TSVNLQECELDDCNFSNAILGKTNFSKSSLLNINLSNAIYKETKFIGAKFENVT 460
                 555666666666666666677777888888999999998888888999998775 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.035
       CfAFP  30 anskcvkstltncyidnselessictrsqysdayvkksv 68 
                  ns   +s  tnc+  + +les+i  ++++++++  +++
  EFC36767.1 483 CNSDLSNSNFTNCNAIDCNLESTILRKTNFEKSQFDNCR 521
                 356666666666666666666666666555544444333 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 2.1
       CfAFP  40 tncyidnselessic..trsqysdayvkksvttdcni 74 
                     id  +++ s c  t+++++ +y+ ++   +cn 
  EFC36767.1 543 GLIGIDLVRVDLSNCklTKTDFTVSYIFETNFLNCNF 579
                 4555666666666554467777778888887778875 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.087
       CfAFP  36 kstltncyidnselessictrsqysdayvkksvttdcnidksq 78 
                 +   tn +i++s+ e+s+ ++++ +  + kk    +cn+ +++
  EFC36767.1 612 NVKFTNTNIEKSKFENSTFVKCKIQM-NFKKDSLQHCNVIECD 653
                 55678999999999988888887654.4555556677776655 PP

>> zf-RING_10  zinc RING finger of MSL2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  11.7     0.013        14       1      48 [.      42      87 ..      42     112 .. 0.77
   2 ?   -1.4   0.3       2.4   2.6e+03      34      45 ..     100     111 ..      87     124 .. 0.79
   3 ?   -1.7   0.0       2.9   3.3e+03      25      41 ..     579     595 ..     572     613 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.013
  zf-RING_10  1 lsCvvCckLLvdPlepkekeCqHyvCrlCvgkkkklkpsCsqCk..dyek 48
                l C++C    vdP++ ++  C+   C +Cv k    ++ C++C+  d++k
  EFC36767.1 42 LICSICLLPFVDPISHNSDACGNTFCLKCVEK----VSDCPMCRevDFKK 87
                68****************************87....56788888555543 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.4
  zf-RING_10  34 kklkpsCsqCkd 45 
                  klk +C +Ck+
  EFC36767.1 100 DKLKVKCGMCKN 111
                 589999999995 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 2.9
  zf-RING_10  25 vCrlCvgkkkklkpsCs 41 
                  C   ++ k+++ ++C+
  EFC36767.1 579 FCMEVLRSKHNIISNCD 595
                 46666677777777776 PP

>> OmpH  Outer membrane protein (OmpH-like)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8  19.6     0.015        16      19      91 ..     130     204 ..     123     219 .. 0.65

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.015
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTS....-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        OmpH  19 aaqeqlekkfkklqaeleakekelqklqeelqkkakkl.e..keekeqelqkkeqelqqkqqqkaqelqkkqqell 91 
                 +a +q+e+ +kkl++e+++k ++lq++ eel +  k++ e   +e+++ l+k+e++l q++++k++ l+++  +++
  EFC36767.1 130 EAYQQVEEFKKKLEQEFQQKSEKLQREHEELIEIVKAEmEqhLREAKENLAKLEENLLQQFKKKEELLESNM-KER 204
                 677888888888888888888888888888876555543344444444488888888885666654444333.333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (927 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2420  (0.134977); expected 358.6 (0.02)
Passed bias filter:                      602  (0.0335769); expected 358.6 (0.02)
Passed Vit filter:                       115  (0.00641419); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 1.04u 0.36s 00:00:01.40 Elapsed: 00:00:00.53
# Mc/sec: 5230.55
//
Query:       EFC36768.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.1e-07   29.7   0.2    1.2e-06   28.7   0.2    1.5  1  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.2   6.7e-11   1.2e-06      23     104 ..      81     165 ..      74     172 .. 0.82

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 6.7e-11
                 EEE-HHHHHHH-HHHHHHHTSTTTTTCCCE.EEEETTSGHHHHHHHHHHHHHSEEEC-...CGGGHHHHHHHHHHHT-HHHHHHHH CS
         BTB  23 fkahkavLaarSpyFkalftskeieessvs.eielddvepeafealLefiYtgeleit...seenleelLaaadllqiprlkkace 104
                 ++ahk+vLa  S+ F+++f+s+++e+ +++  ++ ++ + ++f a++ ++Y   +++    +++ + +lL + d++q  +l + + 
  EFC36768.1  81 IYAHKFVLA-QSEWFRTIFESNMMEQLTNElIVDENEENLDTFTAMIAMMYGNYVPSFsslNSTLVIDLLVCFDKYQATQLFDRVI 165
                 89*****96.7***********5555554445666778889************999988887888999999999999999987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1943.97
//
Query:       EFC36769.1  [L=847]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.5e-05   22.4   1.2    0.00014   21.5   1.2    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
          6    7.9   7.0         17    6.4   0.0    3.1  3  Pilin_N        Archaeal Type IV pilin, N-terminal


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   1.2   1.6e-08   0.00014       7     169 ..     564     744 ..     560     769 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 1.6e-08
  Guanylate_cyc   7 devtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevavesk..... 97 
                    + vt++++++ g  +    ++  ++v +L +++++++++ + + +    +   a m+++++++++ ah +k+a   L ++ +l++v++ +      
     EFC36769.1 564 RVVTVIYMSMDGILDCLDVMEHSDIVFMLGDVFEQVNQIGKTTSGLVYGFENGALMIAFNASSNQVAHQEKAATTTLTLIGKLDNVRKTKWtqahs 659
                    6799999999999999999999****************999999999999999***********************************99446899 PP

  Guanylate_cyc  98 ...........eglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagkiqv..seetyellkeeqfeltergeve 169
                                +++ r  i + +  +g +G +  + + ++Gn       m s++ +  +qv  +e+ y++ + + f l+ +++ e
     EFC36769.1 660 fkssrqisymlDNISFRFCITSRESTCGNVGtNDAKIFSIFGNLRQEFELMASVAREVGVQVlvTEQIYQVVN-QVFVLRYIESKE 744
                    9******************************6666779*****************887666555********9.666665554333 PP

>> Pilin_N  Archaeal Type IV pilin, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       1.7   1.5e+04      22      41 ..      44      64 ..      40      71 .. 0.79
   2 ?    6.4   0.0    0.0019        17       8      36 ..      90     118 ..      88     163 .. 0.78
   3 ?    0.6   4.1      0.12   1.1e+03      14      30 ..     421     437 ..     410     455 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.7
     Pilin_N 22 viaafvlgl.asneekapqas 41
                 i++fv+   +++ +++p+a+
  EFC36769.1 44 SIGSFVVAKnDDPHTDEPNAD 64
                688999998788889999987 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0019
     Pilin_N   8 GviLmvaitvIlaAviaafvlgl.asneek 36 
                   + +++i++++a + a+f  g+ + ++++
  EFC36769.1  90 SSLVLLSIVIVVATFCASFLPGFlS-VSND 118
                 56789*****************953.3333 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.12
     Pilin_N  14 aitvIlaAviaafvlgl 30 
                 +i+ Il++viaa+v+++
  EFC36769.1 421 SIIAILISVIAAVVVSV 437
                 5899**********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (847 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1416  (0.0789782); expected 358.6 (0.02)
Passed bias filter:                      628  (0.0350271); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.87u 0.35s 00:00:01.22 Elapsed: 00:00:00.55
# Mc/sec: 4667.08
//
Query:       EFC36770.1  [L=1534]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.9e-17   63.1   0.1    8.4e-17   62.0   0.1    1.6  1  ABC_tran         ABC transporter
    1.4e-10   41.0   2.2    1.4e-10   41.0   2.2    2.0  2  ABC2_membrane    ABC-2 type transporter
     0.0089   16.6   0.0      0.018   15.6   0.0    1.5  1  OAD_gamma        Oxaloacetate decarboxylase, gamma chain
  ------ inclusion threshold ------
      0.043   14.8   0.1        0.1   13.6   0.1    1.6  1  DUF4834          Domain of unknown function (DUF4834)
       0.13   11.2   0.2       0.19   10.6   0.2    1.2  1  DUF463           YcjX-like family, DUF463


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.0   0.1   2.3e-20   8.4e-17       2     136 ..    1071    1221 ..    1070    1222 .. 0.90

  Alignments for each domain:
  == domain 1  score: 62.0 bits;  conditional E-value: 2.3e-20
                  EEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--..SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH............HHHTC CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............xxxxx RF
    ABC_tran    2 knvslklkegekvaivGenGaGKStLlkllagllkp..teGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren............esdee 84  
                  + v  +++++e++a++G +G+GK++++  l+g+       G+i+l+g++ +    +++rk  g++pq + +++++tv+e+            + +e+
  EFC36770.1 1071 SGVRGEIRNSELLAVMGCSGSGKTSFITSLCGKAYYgnVTGTIKLNGNEASL---TKFRKLTGFVPQLDIMQSQMTVYETlyfaartrldkrKTNEQ 1164
                  6788899*************************98876699******888776...9*******************************9998833333 PP

                  ....HHHHHHHSTTGGTTCBGESTTS.GGS-HHHHHHHHHHHHHHHTSSEEEEESTT CS
                  ....xxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   85 ....iekalsklglkelkdtvvkssp.ssLSgGqkqrvalarallkkpkllllDEpt 136 
                      ++ ++s lgl+++k++++++++ + +SgGqk+rv +   l+ +p++l+lD  t
  EFC36770.1 1165 vdkfVSSLISILGLDDVKHSIIGDEKkRGISGGQKKRVNIGLELAAAPSVLFLDAST 1221
                  445688899999**********988889**************************776 PP

>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.41   1.5e+03      54      74 ..     972     992 ..     961    1007 .. 0.56
   2 !   41.0   2.2   3.8e-14   1.4e-10       1     122 [.    1385    1525 ..    1385    1533 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.41
  ABC2_membrane  54 gllffsvlflafsaltsvapv 74 
                    ++l+f+++f++++++ ++ ++
     EFC36770.1 972 NILGFFFVFICLMLVVGIHSL 992
                    344444445554445544444 PP

  == domain 2  score: 41.0 bits;  conditional E-value: 3.8e-14
  ABC2_membrane    1 tqikallkreflqrwrdpslgllwrliqplllalvfgtvfgn........lg..nsedglnr...............pgllffsvlfla..fsa 67  
                     tq++++lkr + q  rd+s + ++ +    l +l +g++f+         ++  +                      p + + s+l l+  + +
     EFC36770.1 1385 TQFMMCLKRCLFQLTRDTSGF-VLDVGLVYLAGLSIGVIFYEsryigppaTEviD------QcpevmrykcslpvndPIMTMASILGLGlaLCG 1471
                     69****************666.99*****************86664333322333......15555668********77777777665500456 PP

  ABC2_membrane   68 ltsvapvferergvlerelvsplyslsayvlakvlvelpvsllqalifllivyfl 122 
                     l+s+ ++f  e  v+ re+ s++ s+++y+lak l+++p++++  +if+ i+y++
     EFC36770.1 1472 LMSSLSNFGDEITVFIREYESNI-SPMMYFLAKNLIQIPIIMITPAIFISIFYII 1525
                     7888899****************.*****************************97 PP

>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   5.1e-06     0.018       8      47 ..     973    1012 ..     969    1032 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 5.1e-06
   OAD_gamma    8 llGmgvVFvvLilLslvislfskiikkkakkkkkkakaaa 47  
                  +lG+ +VF++L+l + + sl++++ +  +kk + + ++aa
  EFC36770.1  973 ILGFFFVFICLMLVVGIHSLIKYVRSVSNKKRDLEHQEAA 1012
                  79**********************9999999888777765 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1   2.8e-05       0.1       1      68 [.     971    1037 ..     971    1049 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.8e-05
     DUF4834    1 mhfLlfilifiiailviglsilsvilrtvfglgsrkkssksaqkqfgnstnsnqqksqsrsetkeege 68  
                  +++L+f+++fi ++lv+g+  l + +r+v +  +r  ++++a+  + ++ ++++++s++ ++ +++++
  EFC36770.1  971 FNILGFFFVFICLMLVVGIHSLIKYVRSV-SNKKRDLEHQEAAMLEMKEMSGDNTNSKDVRSAYASKN 1037
                  689**************************.44444444444444444444444444444444444444 PP

>> DUF463  YcjX-like family, DUF463
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.2   5.4e-05      0.19       3      23 ..    1083    1103 ..    1082    1127 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 5.4e-05
      DUF463    3 lavTGLsraGKtvfitsLvnq 23  
                  lav G s++GKt fitsL  +
  EFC36770.1 1083 LAVMGCSGSGKTSFITSLCGK 1103
                  89****************765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1534 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       716  (0.0399353); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.06u 0.33s 00:00:01.39 Elapsed: 00:00:00.51
# Mc/sec: 8977.66
//
Query:       EFC36771.1  [L=305]
Description: hypothetical protein NAEGRDRAFT_44865 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-53  180.5   0.0    2.7e-51  174.5   0.0    2.0  1  Actin     Actin
  ------ inclusion threshold ------
       0.11   12.7   0.2         59    4.0   0.0    3.1  3  RL11D     Glycoprotein encoding membrane proteins RL5A and RL


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  174.5   0.0     3e-55   2.7e-51      65     402 ..       1     297 [.       1     301 [. 0.92

  Alignments for each domain:
  == domain 1  score: 174.5 bits;  conditional E-value: 3e-55
       Actin  65 vedGvvedwdaveelwehvlkeelkvdpeehpllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGy 163
                 +++G ++dw  ++ ++  ++++e +++ +e+p+ ++ ++    k+r k++Ei+ E++  p+++++++   s+ +++ +tg+ v +Ga+v++v pV+dG 
  EFC36771.1   1 MKEGEIVDWFLMDSVLGDTFYKECRTEVAEYPMAISVSSYFGLKDRYKLAEILYETYCSPSVMFVNQGRASLRRYA-RTGVDVSIGAGVACVLPVVDGK 98 
                 789**************************************************************99988876655.58******************** PP

       Actin 164 vLkkairrsdlgGkaLteqlkellssknvevtprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksY 262
                 ++k+ i+++++ G++Lt++l +l+ +k ++                        ++l+   k  e  + +++iK ++    e +e     +s+ pe+s+
  EFC36771.1  99 IIKENIKKLNVNGNDLTNYLGQLIAKKGIST----------------------GTELDP--KYCEGVRNIDTIKAKCFLLDEYIE-----ESTTPEQSF 168
                 **************************85554......................122233..3345556699***99988877777.....77899**** PP

       Actin 263 eLPDgseiklgeeRfkvpEiLFdpsligsesaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkii 361
                 ++ D  +i lg+e +++pE LF+p+lig++           g++e+i+ +i+ c+vd r++L++niv +G++sl+++l +Rl+kel +la++++k+ ++
  EFC36771.1 169 TF-DDCTISLGKELYQAPEPLFQPHLIGKDCP---------GLAEVIHSCISSCEVDTREQLYQNIVFSGASSLFKNLAQRLKKELGELAPNNYKIGVT 257
                 **.5568**********************999.........********************************************************** PP

       Actin 362 apeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGssvv 402
                 ap+ e kys+W+G    A+    ++ wv+++ YeEqG+ + 
  EFC36771.1 258 APP-ESKYSVWMGTCAEAESFYNHDKWVTREMYEEQGEAIT 297
                 ***.*********************************9875 PP

>> RL11D  Glycoprotein encoding membrane proteins RL5A and RL6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0     0.057   5.2e+02      27      74 ..      63     110 ..      38     125 .. 0.79
   2 ?    3.8   0.0    0.0076        68      53      96 ..     207     254 ..     197     257 .. 0.71
   3 ?    4.0   0.0    0.0066        59      71      93 ..     273     295 ..     266     301 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.057
       RL11D  27 vfgddGdeslydvtgiGtavvngnaticvsscshtsldlcnlksqdds 74 
                 +f ++G  sl   +  G  v  g   +cv       +   n+k+ + +
  EFC36771.1  63 MFVNQGRASLRRYARTGVDVSIGAGVACVLPVVDGKIIKENIKKLNVN 110
                 689999999999999999998899999998777777666666665555 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.0076
       RL11D  53 icvsscshtsld...lcnlksqddslf.dlsrrlgenmdeedGdlwrl 96 
                  c+ssc  ++ +      + s+ +slf +l++rl++++ e   + +++
  EFC36771.1 207 SCISSCEVDTREqlyQNIVFSGASSLFkNLAQRLKKELGELAPNNYKI 254
                 7*****877643110334568999998569999999888877766666 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.0066
       RL11D  71 qddslfdlsrrlgenmdeedGdl 93 
                 + +s+++  +++  +m ee+G+ 
  EFC36771.1 273 EAESFYNHDKWVTREMYEEQGEA 295
                 5789*****************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1826.05
//
Query:       EFC36772.1  [L=363]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (363 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 2348.36
//
Query:       EFC36773.1  [L=314]
Description: short chain alcohol dehydrogenase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.4e-38  131.6   0.0    3.2e-38  131.1   0.0    1.1  1  adh_short        short chain dehydrogenase
    8.3e-25   87.7   0.0    9.8e-25   87.5   0.0    1.1  1  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
    2.7e-05   23.5   0.0    4.2e-05   22.8   0.0    1.2  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
     0.0013   18.5   0.0     0.0022   17.8   0.0    1.4  1  Methyltransf_31  Methyltransferase domain
     0.0037   17.9   0.0     0.0078   16.9   0.0    1.5  1  Methyltransf_25  Methyltransferase domain
      0.004   16.7   0.0     0.0062   16.0   0.0    1.3  1  Epimerase        NAD dependent epimerase/dehydratase family
     0.0048   16.8   0.0      0.019   14.9   0.0    1.9  3  KR               KR domain
  ------ inclusion threshold ------
       0.02   13.9   0.0      0.031   13.3   0.0    1.2  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
       0.04   14.6   0.0      0.099   13.3   0.0    1.7  1  Methyltransf_11  Methyltransferase domain
       0.09   12.1   0.0       0.26   10.6   0.0    1.6  2  Ubie_methyltran  ubiE/COQ5 methyltransferase family


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.1   0.0   1.8e-41   3.2e-38       2     188 ..      37     243 ..      36     249 .. 0.91

  Alignments for each domain:
  == domain 1  score: 131.1 bits;  conditional E-value: 1.8e-41
                 EEEEESTTSHHHHHHHHHHHHT.T-EEEEEESCHHHHHHHHHH.HHHT.TSEEEEEE-TTTSHHHHHHHHHHHHHHH.....SSESEEEE---S..... CS
   adh_short   2 vvlvtGassGIGraiakelake.Gakvvvvdrseekleevake.lkee.gakalaiqvDvtdreevealvekavkkl.....gkldvLvnNAGi..... 87 
                 vv+v Ga++G+G ai++ l+++ +a+v+ +d+s+e +e+v++e lk+  ++++ +i++++ + ee+e++ e++++ l     +++ +LvnNAG+     
  EFC36773.1  37 VVVVSGAAGGFGTAICRDLLSRfNARVIGLDISKEVMEKVYSEeLKQYgSERLSFIECNICKLEECEKASERIAQILkewktDRVFALVNNAGVsnspk 135
                 8****************998764888988***********976166669999*****************998877666658899**********99999 PP

                 .S--SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHH...HCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGT...EEEEEEEE CS
   adh_short  88 .tgsgpfselseeewervievNltgvflltravlpaml...kqssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakelaptg...irvnavaP 179
                  t++  + e+ e+e  +v+  Nl+g + +tr+++p m+   ++++G+I+nv+Svag+ ++  +  Y++sK+a++g+t+sl++e+++ g    rv+++ P
  EFC36773.1 136 cTERMGIVEYPEDELLDVFGSNLFGHVRMTRLLYPLMKdgqDGHNGAIINVASVAGLLALGFFGFYTSSKFAMVGFTDSLRREMKSLGkkgLRVTCIEP 234
                 98888999******************************99999****************************************87655555******** PP

                 SSBSSHHHH CS
   adh_short 180 GlvdTdmak 188
                 G+ +T++ +
  EFC36773.1 235 GFSKTAILN 243
                 *****9865 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.5   0.0   5.5e-28   9.8e-25       1     180 [.      42     243 ..      42     281 .. 0.85

  Alignments for each domain:
  == domain 1  score: 87.5 bits;  conditional E-value: 5.5e-28
                   TTTTSHHHHHHHH.HHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE.E..EE--TTSHHHHHHHHHHHHH...HH..SSEEEEEE-----EG....C CS
  adh_short_C2   1 GaasgIGraiAka.laeeGaevvltdlneea.kkrveelaeelgae.v..lecDVtdeeqvealveevve...kf..gklDilvnnagiapk....l 83 
                   Gaa g G ai +  l +  a+v+  d+++e  +k   e  +++g+e +  +ec++ + e++e++ e++++   ++  +++  lvnnag++++     
    EFC36773.1  42 GAAGGFGTAICRDlLSRFNARVIGLDISKEVmEKVYSEELKQYGSErLsfIECNICKLEECEKASERIAQilkEWktDRVFALVNNAGVSNSpkctE 138
                   9**********9725788*************9899999999999776346************9977665411166779999**********999998 PP

                   SS-GGGH-HHHHHHHHHHHTHHHHHHHHHHHHHCTSC.....CEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHH...HGGGTEEEEEEEE- CS
  adh_short_C2  84 kgpfletsreefdraldvnlyslfllakaalplmkeg.....gsivnlssvgaervvpnynaygaaKaalealtrylAve...lgpkgiRvNavspg 172
                   +  ++e +++e+ +++  nl + +++++ + plmk+g     g+i+n++sv++  ++     y+ +K a++++t +l +e   lg+kg Rv ++ pg
    EFC36773.1 139 RMGIVEYPEDELLDVFGSNLFGHVRMTRLLYPLMKDGqdghnGAIINVASVAGLLALGFFGFYTSSKFAMVGFTDSLRREmksLGKKGLRVTCIEPG 235
                   999********************************999999*********************************999776333799*********** PP

                   -BHCTGGG CS
  adh_short_C2 173 pikTlaas 180
                   + kT + +
    EFC36773.1 236 FSKTAILN 243
                   ****8854 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   2.3e-08   4.2e-05       1      82 [.      38     122 ..      38     137 .. 0.86

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 2.3e-08
                      EEEETTTSHHHHHHHHHHHHHB-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-....HHHHHHHTT..T-SEEE CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkkkpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrd....kerlekaleelkvdvvf 82 
                      v+v+Ga+G +G +++r +l++  +++i l+ +   + ++ +e  +++ +++l++   + i+++++    +er++++l+e+k d vf
       EFC36773.1  38 VVVSGAAGGFGTAICRDLLSRFNARVIGLDISKEVMEKVYSEELKQYGSERLSFI-ECNICKLEEcekaSERIAQILKEWKTDRVF 122
                      79*******************999*********9*****9998899999999665.777887765222367899999999999998 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   1.2e-06    0.0022      17      69 ..      51     102 ..      37     165 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.2e-06
  Methyltransf_31  17 ltfelaeelgpkaevvGiDiseeaielAre.naqklgldnveFeqgdieelekl 69 
                      ++  l  + +++a+v+G+Dis+e+ e+  + ++++ g+++++F +++i +le+ 
       EFC36773.1  51 ICRDL--LSRFNARVIGLDISKEVMEKVYSeELKQYGSERLSFIECNICKLEEC 102
                      33333..45679*************98765599*****************8753 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   4.4e-06    0.0078       7      62 ..      46     103 ..      41     123 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 4.4e-06
                      TTSH.HHHHHHCTSTSSEEEEEESSHHHHHHHH.HHHHHTTT.TEEEEESBCCGBSSST CS
  Methyltransf_25   7 GtGr.ltlalakrlgkakvtgvDiseemleaar.eraeeegl.nvefvqgdaedlpfed 62 
                      G G+ ++++l+ r+ +a+v+g+Dis+e +e++  e++++ g  +++f+++++ +l++ +
       EFC36773.1  46 GFGTaICRDLLSRF-NARVIGLDISKEVMEKVYsEELKQYGSeRLSFIECNICKLEECE 103
                      44432678899999.6*********999988652666666669*********9998644 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   3.5e-06    0.0062       1      61 [.      38     107 ..      38     139 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 3.5e-06
                 EEEETTTSHHHHHHHHHHHHCT.SEEEEEES-STTTTCHHCHHC........EEEE--TT-HHHHHHHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekg.yevigldrlssasntarledl........elveldltdrsalerlfk 61 
                 ++V Ga+G  G+a+++ ll++   +vigld  ++  ++   e+l        +++e+++++ +++e++ +
  EFC36773.1  38 VVVSGAAGGFGTAICRDLLSRFnARVIGLDISKEVMEKVYSEELkqygserlSFIECNICKLEECEKASE 107
                 689******************9677*******9998888888889*******999999999885555433 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0     1e-05     0.019       3      77 ..      38     111 ..      37     155 .. 0.78
   2 ?   -2.7   0.0       2.7   4.8e+03     153     165 ..     209     221 ..     161     233 .. 0.57
   3 ?   -1.9   0.0       1.5   2.7e+03     100     132 ..     262     294 ..     258     295 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1e-05
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-.EEEE----TT-HHHHHHHHHHHHH CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealga.evevvaaDvsdkdavealleeika 77 
                 +++ G++Gg+G++++r l+++ +++++ l  s  ++  +k   +el+++g  + +++++ + + ++ e++ e+i +
  EFC36773.1  38 VVVSGAAGGFGTAICRDLLSRFNARVIGLDIS--KEVMEKVYSEELKQYGSeRLSFIECNICKLEECEKASERIAQ 111
                 689*******************9999988888..34444556899***9886799999999999999988776654 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.7
                 HHHHHHHHHHHHH CS
          KR 153 NaflDalaeyrrs 165
                   f D+l ++ +s
  EFC36773.1 209 VGFTDSLRREMKS 221
                 2344444444444 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.5
                 --HHHHHHHHTTTTHHHHHHHHHTTTS--SEEE CS
          KR 100 mtaedleqvlapKvkGawnLhelledesldffv 132
                 ++a+ l+++  pKv G    ++++++++l +++
  EFC36773.1 262 KSAAILRNAQPPKVIGDAICEQIFSSNNLPHLI 294
                 566667888899****99999999999887765 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.7e-05     0.031       1      70 [.      39     112 ..      39     128 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.7e-05
   3Beta_HSD   1 vvtGgaGFlGralvkeLvrleelkevrvlDlrespelleelskvnvkk.......viegDvtdkdkleealegvdvv 70 
                 vv G+aG  G a+++ L+++ +    rv+ l++s+e+ e++ + + k+       +ie+ +++ ++ e+a e +  +
  EFC36773.1  39 VVSGAAGGFGTAICRDLLSRFN---ARVIGLDISKEVMEKVYSEELKQygserlsFIECNICKLEECEKASERIAQI 112
                 799***************9986...677777777776666655555555555588**************99887665 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   5.5e-05     0.099       4      55 ..      46      99 ..      42     113 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.5e-05
                     T-TTSHHHHHHHHTTSEEEEEES-HHHHHHH.HHHCCHHT-.EEEETTEECCCT CS
  Methyltransf_11  4 GcGtGrlaealakrgarvvgvDlskemlkla.kekaseegl.kvefvvadaekl 55
                     G Gt +    l +  arv+g+D+ske+++ + +e+ ++ g  +++f+++++ kl
       EFC36773.1 46 GFGTAICRDLLSRFNARVIGLDISKEVMEKVySEELKQYGSeRLSFIECNICKL 99
                     677777777788777***********9966635555555557899999999887 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00014      0.26      50     117 ..      36     106 ..      21     112 .. 0.83
   2 ?   -2.0   0.0         1   1.8e+03     129     160 ..     211     242 ..     197     248 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00014
                      EEEEES-TT-HHHHHHHHHHHHHH..EEEEEES-HH.HHHHHHHHHHHHTSSTEEEEE--TTT-TTS-T-E CS
  Ubie_methyltran  50 kvlDvagGtgDlafklsdsvgekg..kvvvlDinen.mLkvgekklkeegkinieflqanaeeLpfeddsf 117
                      +v+ v+g +g +  ++ + + +++  +v++lDi+++ m kv  + lk+ g  ++ f+  n  +L++ +++ 
       EFC36773.1  36 RVVVVSGAAGGFGTAICRDLLSRFnaRVIGLDISKEvMEKVYSEELKQYGSERLSFIECNICKLEECEKAS 106
                      5667888889999999999888887799*****97626688999********************9987664 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1
                      -S-HHHHHHHHHHHEEEEEEEEEEE..E----SH CS
  Ubie_methyltran 129 vtDklkaLkeayrvlkpGGrlvvle..fskvelp 160
                      +tD l+  +e+    k G r++++e  fsk  + 
       EFC36773.1 211 FTDSLR--REMKSLGKKGLRVTCIEpgFSKTAIL 242
                      555443..67777889999999999666776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (314 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       736  (0.0410508); expected 358.6 (0.02)
Passed bias filter:                      659  (0.0367561); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 1903.25
//
Query:       EFC36774.1  [L=811]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00012   22.1  13.5    0.00019   21.5  13.5    1.3  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5  13.5     1e-08   0.00019       2      39 ..     217     254 ..     216     255 .. 0.92

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 1e-08
                 S-HHHHHCT---STSSSS-HHHHHCT..HHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkkln..leCtfysesskr 39 
                 aC++Crk +  C +++P C +Ckkl+   +C+  + ++kr
  EFC36774.1 217 ACTECRKAHKACTGERP-CDRCKKLGmeDKCK-STIRKKR 254
                 9****************.********999**9.8877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (811 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1086  (0.0605723); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.81u 0.27s 00:00:01.08 Elapsed: 00:00:00.48
# Mc/sec: 5119.61
//
Query:       EFC36775.1  [L=451]
Description: beta-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.5e-70  235.4   0.0    1.2e-69  234.4   0.0    1.5  1  Tubulin          Tubulin/FtsZ family, GTPase domain
    3.6e-41  140.3   0.1    5.5e-41  139.7   0.1    1.3  1  Tubulin_C        Tubulin C-terminal domain
    3.6e-05   24.1   0.0    9.8e-05   22.6   0.0    1.7  1  Misat_Tub_SegII  Misato Segment II tubulin-like domain
    0.00063   19.0   0.0     0.0029   16.9   0.0    1.9  2  Tubulin_2        Tubulin like
     0.0011   18.6   0.0     0.0022   17.7   0.0    1.5  1  Tubulin_3        Tubulin domain


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  234.4   0.0   3.4e-73   1.2e-69       1     196 [.       3     211 ..       3     212 .. 0.99

  Alignments for each domain:
  == domain 1  score: 234.4 bits;  conditional E-value: 3.4e-73
                 EEEEEEEHHHHHHHHHHHHH...HHHCH..............HHHT.....TTEEEEE....EEESBHHHHHTS-GS........EEEE--CCCCTTC- CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiqsdg..........dslesfFsesgkveyiprsvaidtdpqvlneikags..elfnpnklllgkegagnng 87 
                 ei++i+ GqcGnqig ++we++ +ehg++++g          ++++++++e   ++y+pr++++d++p ++++++ag+  ++f+p+++++g++gagnn+
  EFC36775.1   3 EIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGayhgdsdlqlERINVYYNEATGGRYVPRAILMDLEPGTMDSVRAGPygQIFRPDNFVFGQTGAGNNW 101
                 79**************************98889******************999********************************************* PP

                 -TT-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--.GG.G-HHHHHHHHHHHHHHHHT-SEEE CS
     Tubulin  88 aggypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs.efsevvvepynailalkelieesdavi 185
                 a+g+++ g+e+++++l+ +rke+e+cd+lqgf+i +slgGGTGSG+g++++++++eeyp+++++t++v+Ps + s+ vvepyna l++++l+e++d v+
  EFC36775.1 102 AKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVFPSpKVSDTVVEPYNATLSVHQLVENADEVM 200
                 *************************************************************************************************** PP

                 EEEHHHHHCCS CS
     Tubulin 186 vidNdaLlkil 196
                 +idN+aL++i+
  EFC36775.1 201 CIDNEALYDIC 211
                 **********8 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.7   0.1   1.5e-44   5.5e-41       1     125 [.     261     382 ..     261     383 .. 0.99

  Alignments for each domain:
  == domain 1  score: 139.7 bits;  conditional E-value: 1.5e-44
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEESSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEECECT CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirGdvepkevnkavqrikekkkaqfveWiptgikvalnkkspy 99 
                 PrlhF+l+++aPl+s+ +++++ ++v ++t++++++kn+m+++dpr+g+yl++++++rG++++kev++++ ++++k++++fveWip++ik ++++ +p 
  EFC36775.1 261 PRLHFFLIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAASDPRHGRYLTASAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDIPPR 359
                 9************************************************************************************************** PP

                 -TTTSSCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C 100 vkkqskvsvlmlaNttsiaelfkrll 125
                 + k+    +++++N+t+i+e+fkr++
  EFC36775.1 360 GLKMA---ATFIGNSTAIQEMFKRVS 382
                 **999...****************86 PP

>> Misat_Tub_SegII  Misato Segment II tubulin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   2.7e-08   9.8e-05       1      68 [.       2      71 ..       2      87 .. 0.76

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 2.7e-08
  Misat_Tub_SegII  1 rEivtlqlGnyaNyvgtHfWNtQesyftydeeeeesevdhdvlfre...getkqgqvtytPRllivDlkgs 68
                     rEiv +q G+  N +g+ fW +  +    d++    + d+d++       +++ +   y+PR++++Dl+ +
       EFC36775.1  2 REIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGA-YHGDSDLQLERinvYYNEATGGRYVPRAILMDLEPG 71
                     8********************9998887788777.45555555433111223566789*********9754 PP

>> Tubulin_2  Tubulin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0     8e-07    0.0029     138     203 ..     112     176 ..      97     194 .. 0.78
   2 ?   -0.7   0.0      0.18   6.4e+02      53     104 ..     302     348 ..     248     354 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 8e-07
   Tubulin_2 138 alrdaikrlrgsage.eeglnvfVvgSLaGGTGSGiflDvayllrkilkeekqkvkiiglvllPdvf 203
                  ++++++ +r++a++ + +  + ++ SL GGTGSG+   ++  +r+++++      ++ ++++P+v 
  EFC36775.1 112 LIDSVLDVVRKEAEScDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMM--MTFSVFPSPKVS 176
                 566666666665555555566789**************************997..589999999985 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.18
   Tubulin_2  53 detaekageslksrekealsissaevdr.ilrnllreetasaypsieeWlppe 104
                 ++ + + g++l++++++   +s +evd+ +l+ +      +++++  eW+p++
  EFC36775.1 302 ASDP-RHGRYLTASAMFRGRMSTKEVDEqMLNVQN-----KNSSYFVEWIPNN 348
                 2233.567788888888889999999751555553.....3344677999765 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   6.2e-07    0.0022      64     148 ..     120     198 ..     102     238 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 6.2e-07
   Tubulin_3  64 lrpfaeecdqlrglqvftgvddaWG.GfaakylerlrdeygkksilvWvlaleeklkkkkkaklerklkklnkarslkelseqasl 148
                 +r+ ae cd l+g+q+  +     G G ++  + ++r+ey+ + ++++ +   +++ +      +  ++  n + s+++l e+a  
  EFC36775.1 120 VRKEAESCDCLQGFQIAHSLGGGTGsGMGTLLISKIREEYPDRMMMTFSVFP-SPKVS------DTVVEPYNATLSVHQLVENADE 198
                 6999***************99887769***************9987776533.22222......1223445555566666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       533  (0.0297284); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.47
# Mc/sec: 2910.31
//
Query:       EFC36776.1  [L=152]
Description: polyubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.4e-63  208.2   5.9    6.7e-31  105.9   0.5    2.0  2  ubiquitin    Ubiquitin family
    2.9e-30  103.9   7.5    8.2e-15   54.4   1.0    2.0  2  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
    5.5e-09   36.4   3.2     0.0014   19.0   0.3    3.1  2  Ubiquitin_2  Ubiquitin-like domain
    1.3e-08   34.6   0.2     0.0026   17.7   0.0    2.2  2  TBK1_ULD     TANK binding kinase 1 ubiquitin-like domain
    1.4e-08   34.8   0.4      0.001   19.2   0.0    2.8  2  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
    5.8e-07   29.8   1.6      0.025   14.9   0.2    2.1  2  Ubiquitin_5  Ubiquitin-like domain
    1.2e-06   29.0   0.1      0.015   15.9   0.0    2.1  2  DUF2407      DUF2407 ubiquitin-like domain
      9e-05   22.4   6.5        2.6    8.1   0.1    4.0  4  Ubiquitin_4  Ubiquitin-like domain
  ------ inclusion threshold ------
      0.043   13.7   0.3        3.3    7.6   0.1    2.2  2  Coagulin     Coagulin
       0.05   13.8   0.6       0.84    9.8   0.1    2.3  2  DUF3861      Domain of Unknown Function with PDB structure (D
      0.072   13.5   1.0       0.84   10.0   0.2    2.5  3  bPH_3        Bacterial PH domain
       0.11   12.2   0.0          7    6.4   0.0    2.3  2  Raf1_HTH     Rubisco accumulation factor 1 helix turn helix d
       0.14   12.3   1.4         17    5.6   0.2    2.2  2  ProRS-C_2    Prolyl-tRNA synthetase, C-terminal
       0.22   11.7   1.5        2.2    8.5   0.2    2.6  3  PI3K_rbd     PI3-kinase family, ras-binding domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  105.5   0.6   6.6e-34   8.4e-31       1      72 []       3      74 ..       3      74 .. 0.99
   2 !  105.9   0.5   5.2e-34   6.7e-31       1      72 []      79     150 ..      79     150 .. 0.99

  Alignments for each domain:
  == domain 1  score: 105.5 bits;  conditional E-value: 6.6e-34
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                ++vktl+g++itleve++d++e++K k+++kegi ++qqrLi++Gk+Led rt+ +y+iq++stlhlvlrlr
  EFC36776.1  3 LFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQLEDGRTINDYNIQKDSTLHLVLRLR 74
                79*******************************************************************986 PP

  == domain 2  score: 105.9 bits;  conditional E-value: 5.2e-34
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 ++vktl+gk+it+e+e++dtve+ K+ki +kegip +qqrLiy+Gk+Led rt+++y++q++st+hlvlrlr
  EFC36776.1  79 LFVKTLTGKTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQLEDGRTIGDYNLQKDSTVHLVLRLR 150
                 79*******************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.7   0.8   1.1e-17   1.4e-14       1      72 []       1      71 [.       1      71 [. 0.98
   2 !   54.4   1.0   6.4e-18   8.2e-15       1      72 []      77     147 ..      77     147 .. 0.98

  Alignments for each domain:
  == domain 1  score: 53.7 bits;  conditional E-value: 1.1e-17
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                +++++k+ +g +++++V+++  +++++++ ++k+gi++ +++rLiF G++L++  t++d+ i++++t+++v+
  EFC36776.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISP-DQQRLIFAGKQLEDGRTINDYNIQKDSTLHLVL 71
                79************************************.******************************986 PP

  == domain 2  score: 54.4 bits;  conditional E-value: 6.4e-18
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 +++++k+ +gk+++i+ +++ tv++++++  +k+gip  +++rLi+ G++L++  t++d+ +++++t+++v+
  EFC36776.1  77 MQLFVKTLTGKTITIEMESNDTVENMKQKIFDKEGIPS-DQQRLIYAGKQLEDGRTIGDYNLQKDSTVHLVL 147
                 79************************************.******************************996 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.2   8.2e-06      0.01      18      79 ..      15      68 ..       3      71 .. 0.79
   2 !   19.0   0.3   1.1e-06    0.0014      14      79 ..      87     144 ..      77     146 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 8.2e-06
                 EEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2 18 rrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79
                   ++++++ie++K+k++   G+sp+++rL +          k  +d ++ ++Y+++  +++h
   EFC36776.1 15 LEVESNDSIENVKRKVQDKEGISPDQQRLIFA--------GKQLEDGRTINDYNIQKDSTLH 68
                 5678899**********************997........4445677777777777777776 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 1.1e-06
                  SEEEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2  14 vsserrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79 
                  +  ++ +++++t+e++K+k+    G++ +++rL +          k  +d ++ g+Y+++  +++h
   EFC36776.1  87 KTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYA--------GKQLEDGRTIGDYNLQKDSTVH 144
                  567788999************************998........4556788888888888888888 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   1.1e-05     0.015      19      55 ..      17      51 ..       9      72 .. 0.83
   2 !   17.7   0.0     2e-06    0.0026      15      52 ..      89     126 ..      80     142 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.1e-05
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrllle 55
                +++++ ++++  +v+++  i++++Q l+f g++l  e
  EFC36776.1 17 VESNDSIENVKRKVQDKEGISPDQQRLIFAGKQL--E 51
                6789999*************************87..3 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 2e-06
    TBK1_ULD  15 hkiYihpyntvaifqeevakqTkiaaekQellfeghrl 52 
                 ++i +++++tv+++ ++++++  i++++Q l++ g++l
  EFC36776.1  89 ITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQL 126
                 66778999***************************997 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   7.5e-05     0.096      18      87 ..      15      71 ..       2      75 .. 0.72
   2 !   19.2   0.0   7.8e-07     0.001      11      87 ..      85     147 ..      77     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.5e-05
                 EEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2 18 vkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87
                 ++ +++++++++k+kv      dke    s+++ +li aGk Le+ +t+++++++        +++H+v+
   EFC36776.1 15 LEVESNDSIENVKRKVQ-----DKEG--ISPDQQRLIFAGKQLEDGRTINDYNIQKD------STLHLVL 71
                 56677777777777774.....4444..567778****************9965433......3466665 PP

  == domain 2  score: 19.2 bits;  conditional E-value: 7.8e-07
                  TS-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  11 dGsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                   G+ +  +++++++tv+++k+k++++     e  p++    +li+aGk Le+ +t+++++l+         ++H+v+
   EFC36776.1  85 TGK-TITIEMESNDTVENMKQKIFDK-----EGIPSDQ--QRLIYAGKQLEDGRTIGDYNLQKDS------TVHLVL 147
                  577.77789999************74.....4455544..48****************9655433......466665 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.2     2e-05     0.025      34      93 ..      13      73 ..       5      78 .. 0.83
   2 !   14.3   0.1     3e-05     0.039      34      93 ..      89     149 ..      80     151 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2e-05
  Ubiquitin_5 34 klletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93
                  +le++ + + +++ +k+ ++ g+  ++ +li  gk+le ++t+++ +++++s + +vL+l
   EFC36776.1 13 ITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQLEDGRTINDYNIQKDSTLhLVLRL 73
                 5677777778889999999999***************************999875467765 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 3e-05
  Ubiquitin_5  34 klletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                   ++e++ + t++++ +ki ++ g+  ++ +li+ gk+le ++t+ + +++++s v +vL+l
   EFC36776.1  89 ITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQLEDGRTIGDYNLQKDSTVhLVLRL 149
                  5667777778999************************************999998567765 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.1   0.00024       0.3      15      63 ..      14      58 ..       7      86 .. 0.82
   2 !   15.9   0.0   1.2e-05     0.015      16      62 ..      89     133 ..      67     145 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00024
     DUF2407 15 eLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslas 63
                +L+++  ++ +++++k+ + ++    ++  + rLI+aG+ Led  ++++
  EFC36776.1 14 TLEVE--SNDSIENVKRKVQDKE--GISPDQQRLIFAGKQLEDGRTIND 58
                56666..5667888999999887..88999999**********998875 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 1.2e-05
     DUF2407  16 LdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttsla 62 
                 ++i+  ++ tv+++kq i ++    + s + rLIyaG+ Led  ++ 
  EFC36776.1  89 ITIEMESNDTVENMKQKIFDKE--GIPSDQQRLIYAGKQLEDGRTIG 133
                 678888899**********997..88888889**********98875 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.2    0.0047       6.1       1      33 [.       1      33 [.       1      42 [. 0.91
   2 !    6.5   0.1    0.0066       8.5      58      86 ..      43      70 ..      39      73 .. 0.84
   3 !    8.1   0.1     0.002       2.6       1      30 [.      77     106 ..      77     118 .. 0.91
   4 ?    2.7   0.0      0.11   1.4e+02      58      86 ..     119     146 ..     115     149 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0047
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaierk 33
                 +++ vk l g+++ ++v++n +++++k+ ++ k
   EFC36776.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDK 33
                 78999************************9976 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0066
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L+f g++L+ d  ++++y i+++s+l+ v
   EFC36776.1 43 LIFAGKQLE-DGRTINDYNIQKDSTLHLV 70
                 889999986.6789************976 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.002
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkai 30 
                  +++ vk l g+++ +++++n tv+++k+ i
   EFC36776.1  77 MQLFVKTLTGKTITIEMESNDTVENMKQKI 106
                  78999**********************988 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.11
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L++ g++L+ d  ++ +y ++++s+++ v
   EFC36776.1 119 LIYAGKQLE-DGRTIGDYNLQKDSTVHLV 146
                  889999986.6779*********999876 PP

>> Coagulin  Coagulin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.1    0.0026       3.3      12      44 ..       7      39 ..       5      64 .. 0.86
   2 ?    4.5   0.0     0.023        29      12      43 ..      83     114 ..      80     143 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0026
    Coagulin 12 tllgrkvivsteikdkiekaveavadkdevsgr 44
                tl gr+  +  e +d ie+  + v dk+++s  
  EFC36776.1  7 TLTGRTITLEVESNDSIENVKRKVQDKEGISPD 39
                789***************************964 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.023
    Coagulin  12 tllgrkvivsteikdkiekaveavadkdevsg 43 
                 tl g++  +  e +d +e+  + + dk+++  
  EFC36776.1  83 TLTGKTITIEMESNDTVENMKQKIFDKEGIPS 114
                 788999**********************9954 PP

>> DUF3861  Domain of Unknown Function with PDB structure (DUF3861)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   0.00066      0.84      19      60 ..       9      50 ..       5      84 .. 0.90
   2 ?    2.2   0.1      0.16     2e+02      19      59 ..      85     125 ..      78     128 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00066
     DUF3861 19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglkL 60
                + +++++e+e+ d i ++ +++++ke++++d+++ +  g +L
  EFC36776.1  9 TGRTITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQL 50
                5579**************************999877777665 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.16
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d + ++ +++ +ke++ +d+++ +  g +
  EFC36776.1  85 TGKTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQ 125
                 557999********999999999999999998877666655 PP

>> bPH_3  Bacterial PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       1.9   2.5e+03      71      91 ..       7      28 ..       3      32 .. 0.58
   2 ?   10.0   0.2   0.00065      0.84      29      93 ..      40     106 ..      36     108 .. 0.90
   3 ?    0.5   0.0      0.62   7.9e+02      29      53 ..     116     140 ..     114     149 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.9
       bPH_3 71 t.sgktitidnidksevrkive 91
                t  g tit++  ++++++++ +
  EFC36776.1  7 TlTGRTITLEVESNDSIENVKR 28
                4456666666666666666555 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00065
       bPH_3  29 nkRiifldpkmfggkdfeeipYksIksvdlkkgl.lgakitlet.sgktitidnidksevrkiveai 93 
                 ++R+if  ++   g++++++  ++ +  +l  +l  g ++ ++t  gktiti++ ++++v+++ + i
  EFC36776.1  40 QQRLIFAGKQLEDGRTINDYNIQKDSTLHLVLRLrGGMQLFVKTlTGKTITIEMESNDTVENMKQKI 106
                 58********9999999**99999999999999977778999999********99*****9997765 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.62
       bPH_3  29 nkRiifldpkmfggkdfeeipYksI 53 
                 ++R+i+  ++   g+++ ++ +++ 
  EFC36776.1 116 QQRLIYAGKQLEDGRTIGDYNLQKD 140
                 58********999999999988875 PP

>> Raf1_HTH  Rubisco accumulation factor 1 helix turn helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.05        64      35      55 ..      29      49 ..      26      52 .. 0.86
   2 ?    6.4   0.0    0.0054         7      33      55 ..     103     125 ..     101     128 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.05
    Raf1_HTH 35 eIfEaTGiepvqQnqliVaaq 55
                ++ ++ Gi+p qQ ++  + q
  EFC36776.1 29 KVQDKEGISPDQQRLIFAGKQ 49
                678999********9998877 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0054
    Raf1_HTH  33 pqeIfEaTGiepvqQnqliVaaq 55 
                  q+If++ Gi   qQ ++  + q
  EFC36776.1 103 KQKIFDKEGIPSDQQRLIYAGKQ 125
                 599************99988877 PP

>> ProRS-C_2  Prolyl-tRNA synthetase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.2     0.014        17       6      26 ..      16      36 ..      12      37 .. 0.85
   2 ?    5.6   0.1     0.014        18       6      26 ..      92     112 ..      88     117 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.014
                S--....HHHHHHHCTTT-SE CS
   ProRS-C_2  6 aenvnlllenikeklsekkGv 26
                ++++n   en+k k+++k G+
  EFC36776.1 16 EVESNDSIENVKRKVQDKEGI 36
                5678999***********998 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.014
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n  +en+k+k+ +k G+
  EFC36776.1  92 EMESNDTVENMKQKIFDKEGI 112
                 567899************997 PP

>> PI3K_rbd  PI3-kinase family, ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.24   3.1e+02      28      50 ..      10      32 ..       2      43 .. 0.80
   2 ?    8.5   0.2    0.0017       2.2      27      52 ..      85     112 ..      76     138 .. 0.81
   3 ?   -2.5   0.0       4.4   5.6e+03      92     103 ..     137     148 ..     134     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.24
                SEEEEEEEETTS-HHHHHHHHHH CS
    PI3K_rbd 28 qqkvtlkvnpnstpesllaealr 50
                  ++tl+v+ n++ e+++ ++  
  EFC36776.1 10 GRTITLEVESNDSIENVKRKVQD 32
                5689*********9999887655 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0017
                 -SEEEEEEEETTS-HHHHHHHHHHC..H CS
    PI3K_rbd  27 kqqkvtlkvnpnstpesllaealrk..k 52 
                 + +++t++++ n+t+e+++++++ k   
  EFC36776.1  85 TGKTITIEMESNDTVENMKQKIFDKegI 112
                 46799******************99442 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 4.4
                 HHCT--EEEEEE CS
    PI3K_rbd  92 lksgrephLvLv 103
                 l++++++hLvL+
  EFC36776.1 137 LQKDSTVHLVLR 148
                 678888999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       665  (0.0370907); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.42u 0.24s 00:00:00.65 Elapsed: 00:00:00.42
# Mc/sec: 1079.69
//
Query:       EFC36777.1  [L=1285]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.9e-16   60.2   6.1    2.1e-09   37.6   0.1    4.1  4  BTB_2         BTB/POZ domain
  ------ inclusion threshold ------
       0.11   12.8   0.4       0.39   11.0   0.1    2.2  2  BTB           BTB/POZ domain
        1.6    8.9   7.1       0.32   11.1   1.8    2.7  2  Complex1_LYR  Complex 1 protein (LYR family)


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.1     0.023   1.4e+02       1      18 [.      95     112 ..      95     129 .. 0.86
   2 !   20.2   0.1   9.5e-08   0.00057      37      88 ..     193     249 ..     172     253 .. 0.72
   3 !   37.6   0.1   3.5e-13   2.1e-09       1      91 [.     339     430 ..     339     433 .. 0.87
   4 ?   -4.3   0.1         3   1.8e+04      46      62 ..     858     874 ..     850     880 .. 0.76

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.023
                 EEEEETTEEEEEEHHHHH CS
       BTB_2   1 vklnVgGtrfetskstLs 18 
                 v+l VgG+ f t+ +tL+
  EFC36777.1  95 VVLKVGGKFFYTTMKTLM 112
                 7899*************8 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 9.5e-08
                 EETTTTEEEE-S-HHHHHHHHHHHHS.S-B---.....TTS-HHHHHHHHHHHT--T CS
       BTB_2  37 ydeetneyffDRspklFetiLnyyrtggkLhrp.....eevelkslleElefyglee 88 
                   +++   f DR+p++Fe+iL+ +r+ggk++       +  el+++leE +++  e+
  EFC36777.1 193 EANKSAISFPDRNPDYFEYILEHLRQGGKVKSLgieklNADELENILEESRYFATEK 249
                 4555666799******************99875221113445667889999997666 PP

  == domain 3  score: 37.6 bits;  conditional E-value: 3.5e-13
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-B--....-TTS-HHHHHHHHHHHT--TT-B CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtggkLhr....peevelkslleElefygleelll 91 
                 vk++++G +f +  + L+++ + lL+k       ++  +e++++f+DR+pklF+ i  y+ +ggk ++     ++++  +l++E+efygl++l +
  EFC36777.1 339 VKIDISGQIFTIPFTSLRKYENFLLSKYILSP--SFCLNENGCVFIDRNPKLFALIHGYIISGGKFNHfpknLSQEKKLQLKQEAEFYGLTTL-V 430
                 89****************99**9**9999955..8999999**********************99964211146778889**********998.4 PP

  == domain 4  score: -4.3 bits;  conditional E-value: 3
                 E-S-HHHHHHHHHHHHS CS
       BTB_2  46 fDRspklFetiLnyyrt 62 
                 +DR+++ +e+ L+ y +
  EFC36777.1 858 VDRQSTTYEYRLYKYSK 874
                 79999999998877655 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   6.5e-05      0.39      30     101 ..     172     252 ..     171     261 .. 0.79
   2 ?   -3.3   0.1       1.8   1.1e+04      30      50 ..     750     769 ..     750     773 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 6.5e-05
                 HHHH-HHHHHHHTST...TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-......CGGGHHHHHHHHHHHT-HHHHH CS
         BTB  30 LaarSpyFkalftsk...eieessvseielddvepeafealLefiYtgeleit......seenleelLaaadllqiprlkk 101
                 ++a  + Fk++f s+   e +e+++s i  +d +p+ fe +Le +  g    +      + ++le++L+  +++  ++l +
  EFC36777.1 172 VCAQDNLFKVMFDSGfgiERDEANKSAISFPDRNPDYFEYILEHLRQGGKVKSlgieklNADELENILEESRYFATEKLSE 252
                 5788899*********99778888899****************98655433335777887788888888888887777765 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.8
                 HHHH-HHHHHHHTSTTTTTCC CS
         BTB  30 LaarSpyFkalftskeieess 50 
                 L++ S yF +  +++ +ee++
  EFC36777.1 750 LSSKSRYFGRRNNNN-KEEKN 769
                 8999****9999999.45554 PP

>> Complex1_LYR  Complex 1 protein (LYR family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   1.8   5.4e-05      0.32      22      42 ..    1010    1031 ..    1003    1039 .. 0.83
   2 ?   -4.4   0.3         3   1.8e+04      28      36 ..    1204    1212 ..    1203    1213 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.4e-05
  Complex1_LYR   22 treyfrrriRdeFrknkhvt.D 42  
                    ++++ rr++R+eFr+n +v+ D
    EFC36777.1 1010 QKHEQRRKARKEFRRNESVKfD 1031
                    58999*************9944 PP

  == domain 2  score: -4.4 bits;  conditional E-value: 3
  Complex1_LYR   28 rriRdeFrk 36  
                    ++i +eFrk
    EFC36777.1 1204 NKIEQEFRK 1212
                    68999**98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1586  (0.08846); expected 358.6 (0.02)
Passed bias filter:                      709  (0.0395449); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.02u 0.32s 00:00:01.34 Elapsed: 00:00:00.50
# Mc/sec: 7762.50
//
Query:       EFC36778.1  [L=176]
Description: hypothetical protein NAEGRDRAFT_82114 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.2e-33  114.9   0.3    1.2e-33  114.9   0.3    1.4  2  CutA1         CutA1 divalent ion tolerance protein
    8.3e-19   67.2   8.6    2.1e-18   65.8   8.6    1.7  1  TFIIS_C       Transcription factor S-II (TFIIS)
  ------ inclusion threshold ------
       0.05   13.8   0.5       0.28   11.4   0.1    2.2  2  Pox_vIL-18BP  Orthopoxvirus interleukin 18 binding protein
      0.077   12.5   2.1        0.2   11.2   2.1    1.7  1  TF_Zn_Ribbon  TFIIB zinc-binding
       0.09   13.1   0.3        1.2    9.5   0.0    2.2  2  PSCyt3        Protein of unknown function (DUF1588)
       0.21   11.7   5.6      0.073   13.1   2.9    1.7  2  Elf1          Transcription elongation factor Elf1 like
       0.46   10.8   6.6       0.41   10.9   3.6    2.3  2  IBR           IBR domain, a half RING-finger domain


Domain annotation for each model (and alignments):
>> CutA1  CutA1 divalent ion tolerance protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  114.9   0.3   4.8e-37   1.2e-33       5      98 ..      14     106 ..      10     107 .. 0.95
   2 ?   -3.3   0.0       3.3   8.3e+03      28      40 ..     139     150 ..     132     165 .. 0.59

  Alignments for each domain:
  == domain 1  score: 114.9 bits;  conditional E-value: 4.8e-37
                 EEESSHHHHHHHHHHHHHTTS-SEEEEEEEEEEEEEETTEEEEEEEEEEEEEEEGGGHHHHHHHHHHHSSSSS-EEEEEEESEEEHHHHHHHHH CS
       CutA1   5 vtapseeeakklaralveeklaACvnilpkieSvYrWkgkieedkEvllliktreekveelekrvkelhpyevpeiialpieagseaYlkWiee 98 
                 vt p  ++a+ +a+al+++kl+ACvni+p+++S+Y+W++ki++d+E+ll++kt+ +  ++++++vk++h+y+vpe+i ++i +g+e+Yl+Wi++
  EFC36778.1  14 VTSP-VQKAEFIAQALLKDKLVACVNIVPQVKSMYWWEDKICTDEEALLILKTQVDLKSQVVDCVKKNHEYKVPEVIFMDIMDGNEDYLDWIRK 106
                 5555.789************************************************************************************97 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.3
                 EEEEEEEEEEEEE CS
       CutA1  28 CvnilpkieSvYr 40 
                 C ++ + ++++Y+
  EFC36778.1 139 CTKCQS-TQCTYY 150
                 444333.555554 PP

>> TFIIS_C  Transcription factor S-II (TFIIS)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.8   8.6   8.3e-22   2.1e-18       1      39 []     137     175 ..     137     175 .. 0.98

  Alignments for each domain:
  == domain 1  score: 65.8 bits;  conditional E-value: 8.3e-22
     TFIIS_C   1 akCpkCgsreayffqlQtRsaDEpmtvfykCtkCghrWr 39 
                 +kC kC+s++++++qlQtRs+DEpmt+f++C++Cg+rW+
  EFC36778.1 137 FKCTKCQSTQCTYYQLQTRSSDEPMTTFITCLNCGNRWK 175
                 69************************************7 PP

>> Pox_vIL-18BP  Orthopoxvirus interleukin 18 binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1   0.00011      0.28      40      70 ..      34      64 ..      23      79 .. 0.87
   2 ?    0.1   0.1      0.35     9e+02      33      48 ..     133     148 ..     116     173 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00011
  Pox_vIL-18BP 40 sgcvkfmpkfsymywlakdmksdedakfieh 70
                    cv+ +p++  myw    + +de+a +i +
    EFC36778.1 34 VACVNIVPQVKSMYWWEDKICTDEEALLILK 64
                  68************************98865 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.35
  Pox_vIL-18BP  33 ssgefrcsgcvkfmpk 48 
                    s  f+c+ c      
    EFC36778.1 133 VSSTFKCTKCQSTQCT 148
                   5678999999765443 PP

>> TF_Zn_Ribbon  TFIIB zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   2.1   7.8e-05       0.2       1      27 [.     137     172 ..     137     175 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 7.8e-05
                   EEETTTTCEE.C........HEETSTTCEEESSSSB CS
  TF_Zn_Ribbon   1 ykCPnCgstn.l........veDpergelvCtdCGl 27 
                   +kC +C st+ +          +p+++ ++C +CG+
    EFC36778.1 137 FKCTKCQSTQcTyyqlqtrsSDEPMTTFITCLNCGN 172
                   79*******97799999886566************6 PP

>> PSCyt3  Protein of unknown function (DUF1588)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00047       1.2      17      49 ..      12      44 ..       1      85 [. 0.72
   2 ?    2.0   0.1       0.1   2.6e+02      12      45 ..     116     149 ..     105     171 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00047
      PSCyt3 17 eeetspvkRgkwvreklLceklppppanvpelk 49
                   tspv+++++++++lL +kl +  + vp++k
  EFC36778.1 12 GMVTSPVQKAEFIAQALLKDKLVACVNIVPQVK 44
                6679*****************999988776543 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.1
      PSCyt3  12 tvtskeeetspvkRgkwvreklLceklppppanv 45 
                 +++s+++e+  + + + v +++ c+k ++   + 
  EFC36778.1 116 IQNSSTNENTIIDKPAAVSSTFKCTKCQSTQCTY 149
                 5667777777777777777777777766665555 PP

>> Elf1  Transcription elongation factor Elf1 like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       3.6   9.3e+03      22      25 ..      74      77 ..      62      85 .. 0.50
   2 ?   13.1   2.9   2.8e-05     0.073      12      54 ..     127     173 ..     112     176 .] 0.83

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.6
        Elf1 22 FdCp 25
                 dC 
  EFC36778.1 74 VDCV 77
                2333 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 2.8e-05
        Elf1  12 kkkkkklptkFdCpfCnheksvevkldkkek....iaevsCkvCges 54 
                   k+  ++++F+C  C+++++   +l+++++    +  ++C +Cg +
  EFC36778.1 127 IDKPAAVSSTFKCTKCQSTQCTYYQLQTRSSdepmTTFITCLNCGNR 173
                 45566699***********999999998888889999*******986 PP

>> IBR  IBR domain, a half RING-finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.51   1.3e+03       7      24 ..      62      79 ..      52      85 .. 0.72
   2 ?   10.9   3.6   0.00016      0.41      11      56 ..     132     174 ..     116     176 .] 0.71

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.51
         IBR  7 klkkslesdpnlkwCprp 24
                +lk++++ +++++ C ++
  EFC36778.1 62 ILKTQVDLKSQVVDCVKK 79
                566667777777777654 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00016
         IBR  11 slesdpnlkwCprpdCeaiieksegcksvtCskCgfefCfnCkkew 56 
                  ++s+ ++++C + +C ++  ++ ++++   +   f +C+nC++ w
  EFC36778.1 132 AVSSTFKCTKCQSTQCTYYQLQTRSSDE---PMTTFITCLNCGNRW 174
                 4677888**********99966666444...334455555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       909  (0.0507); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.48
# Mc/sec: 1111.31
//
Query:       EFC36779.1  [L=387]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.048   14.0   0.3       0.11   12.8   0.3    1.6  1  EndoU_bacteria  Bacterial EndoU nuclease


Domain annotation for each model (and alignments):
>> EndoU_bacteria  Bacterial EndoU nuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.3   6.4e-06      0.11      34     104 ..     130     223 ..     105     240 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 6.4e-06
  EndoU_bacteria  34 s..irnteevdknGvytakveikkvdgkt......................kgkgstfFPdtwsaekildaveeaaenknstesqangvvvgges 104
                        i++  +++++G y ++v++ ++d  +                       +    +FP t ++++i+d v++a+e  +++   +n++++++++
      EFC36779.1 130 TilISQMYTNQSHGKYIIRVSYENEDVCEvirkklnltnyksveqlrnetpTNVSECLFPPTFTNKEIIDGVTRAYERIKKDFN-TNQCMITESK 223
                     2577888888899999999999988877789999999999999999998886677899*******************6555555.3336666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (387 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1500  (0.0836633); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2294.50
//
Query:       EFC36780.1  [L=813]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      7e-14   52.2   0.0    2.3e-13   50.5   0.0    2.0  1  RNase_H          RNase H
    1.4e-05   24.9   0.8    1.4e-05   24.9   0.8    2.5  3  Exo_endo_phos_2  Endonuclease-reverse transcriptase
  ------ inclusion threshold ------
      0.014   15.2   0.0       0.05   13.4   0.0    2.0  2  RVT_3            Reverse transcriptase-like
      0.062   12.8   0.0       0.13   11.7   0.0    1.5  1  Exo_endo_phos    Endonuclease/Exonuclease/phosphatase family
       0.15   11.0   0.0       0.31    9.9   0.0    1.4  1  Activator_LAG-3  Transcriptional activator LAG-3


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.5   0.0   6.5e-17   2.3e-13       4     142 ..     476     602 ..     473     603 .. 0.77

  Alignments for each domain:
  == domain 1  score: 50.5 bits;  conditional E-value: 6.5e-17
                 EEEEEEEEEECTTTCEEEEE.EECTT......EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSB CS
     RNase_H   4 vvvYtDGsclgnpgeggaga.vlykeg....arnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkp 97 
                  +++tDGs l   g+ g+g+ +++++g     + +s +++++ +nn aE+ A+i+a+k l  +++  i tDSk +++ +++     k ++     ++ p
  EFC36780.1 476 FIIHTDGSKL--AGKTGMGInIYESGGrlspCKSLSLRINNEYSNNVAEIGAIITAMKLLPNGTTARIHTDSKVAID-VLS--R--KYKG-----NFLP 562
                 589*****66..9999****555555477444478888889*****************999****************.554..1..2222.....2334 PP

                 HTTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHHH CS
     RNase_H  98 vknkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkeaa 142
                 +k  + +++     k+ +v++ +vkgH+    +N  +DrlAk++ 
  EFC36780.1 563 FKT-EFFNIQ--KEKNISVYIIKVKGHEDK--ENIIVDRLAKDGT 602
                 444.333333..346899**********98..8*********986 PP

>> Exo_endo_phos_2  Endonuclease-reverse transcriptase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.8     4e-09   1.4e-05      15     118 ..      52     151 ..      34     152 .. 0.77
   2 ?   -3.3   0.1       2.2     8e+03      43      77 ..     160     192 ..     159     206 .. 0.61
   3 ?   -2.3   0.1       1.1   3.9e+03      44      70 ..     677     706 ..     674     735 .. 0.69

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 4e-09
  Exo_endo_phos_2  15 enlestlekllselkspkiiilGDfNakhplWgsedtdssargeeLiefleehslsllnllksgptfkssng....sstiDltltsdnlalskl 104
                       ++ +++++++ +++++++ii GD+N   ++ ++       r +e   +++  +l+    +++ +t++++++    +s +D +++s+++ + k+
       EFC36780.1  52 VEAMNSITNAVLTCRDEHVIINGDLNINTINPSN------GRDKEWCWLFNLLQLT--EYKTNNKTYIRRQQnritTSRLDHIFVSKDIKVIKE 137
                      45567788888888878*************9988......5566666666666666..6666667777777667789***************** PP

  Exo_endo_phos_2 105 eleeedlgSDHrpi 118
                      el ++ ++ DH p 
       EFC36780.1 138 ELLPPLTSNDHIPF 151
                      ***********986 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.2
  Exo_endo_phos_2  43 hplWgsedtdssargeeLiefleehslsllnllks 77 
                      h +W s   +  ++ ee+i+ +++ + +++++l+ 
       EFC36780.1 160 HLNWRSYIGK--KKREEMIKEINTSNANTFQELNA 192
                      6677775544..66777777777766666665554 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.1
  Exo_endo_phos_2  44 plWgsedtds...sargeeLiefleehsls 70 
                      + W + +++    +++ +eL  ++ ++++ 
       EFC36780.1 677 QIWRNASNSHikyTQKKDELNPTCSDCNCP 706
                      567775555577778888888777777765 PP

>> RVT_3  Reverse transcriptase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.1       3.4   1.2e+04      69      92 ..     257     278 ..     249     285 .. 0.64
   2 ?   13.4   0.0   1.4e-05      0.05       2      79 ..     480     555 ..     479     565 .. 0.87

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3.4
       RVT_3  69 sktvvqllngrekvksselanlld 92 
                 +k++ ++l+++   ++s+++++++
  EFC36780.1 257 CKEIKEQLTDKY--NNSHASHMYQ 278
                 455566666666..5666666665 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 1.4e-05
       RVT_3   2 fdgafkkksgaggagvvirdsnGevllagaek..lqgkasveeAElqALlrGLqlalklgirrlvvegDsktvvqllngr 79 
                 +dg  +k  g++g+g+ i +s G++  + + +  +++ +s+ +AE  A++ +++l  + +  r++  +Dsk+ +++l+++
  EFC36780.1 480 TDG--SKLAGKTGMGINIYESGGRLSPCKSLSlrINNEYSNNVAEIGAIITAMKLLPNGTTARIH--TDSKVAIDVLSRK 555
                 688..8899999***********998777766669*************************99986..7999999888876 PP

>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   3.7e-05      0.13     143     220 ..      66     144 ..      49     156 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.7e-05
                    TTSEEEEEEE-SSSTSGGGBSCGHHHHHHCTTTHH........SSCESCETTTTTTTTTTTEB-BEEEEEECHHHCCEEEEEEECC CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 143 rgapvivaGDfNarpsdddsrvlrtrglalapapv........glyllgggptptyvtraggsrlDrilaspalalfrsgvlpppl 220
                    r+++vi+ GD+N        + +++  +++ ++ +        +  +++ ++     +r ++srlD+i++s++ +++  + lpp+ 
     EFC36780.1  66 RDEHVIINGDLNI-------NTINPSNGRDKEWCWlfnllqltEYKTNNKTYIRRQQNRITTSRLDHIFVSKDIKVIKEELLPPLT 144
                    5789999999999.......333333333333322456777877777777777777788888999***********9999999875 PP

>> Activator_LAG-3  Transcriptional activator LAG-3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   8.8e-05      0.31     199     262 ..     312     375 ..     262     383 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 8.8e-05
                      XXXXXXXXXXXXXXXXXXXX.XXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Activator_LAG-3 199 vptpassihrpspaemrsvc.glsrna..tldltcsplsgglpivdenslavpegewfdklalavae 262
                        tp      psp+ + s+   + r +   +  t+  + +  p  de sl++ +g  ++klal+v e
       EFC36780.1 312 NQTP---TFMPSPSTITSGPrDIGRISyrDVKETIKRMKSNTPGQDEISLDIIKGLKLEKLALIVEE 375
                      4444...45688888887752344544004556899***************************9977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1216  (0.0678231); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.46
# Mc/sec: 5331.34
//
Query:       EFC36781.1  [L=1054]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.015   15.7   1.5       0.02   15.3   0.1    1.9  2  CPBP      CPBP intramembrane metalloprotease
      0.079   12.3   0.2        0.2   11.0   0.0    1.7  2  ThrE      Putative threonine/serine exporter


Domain annotation for each model (and alignments):
>> CPBP  CPBP intramembrane metalloprotease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.2      0.65   5.8e+03      45      76 ..     767     781 ..     753     813 .. 0.52
   2 ?   15.3   0.1   2.2e-06      0.02       4      91 ..     903    1046 ..     900    1047 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.65
                 HHHHHHCSGGGHHHHHHHHHHHHHHHHHHHHT CS
        CPBP  45 silFglaHlpngpsvllaalaGlvlgylylkt 76 
                 s+++gl                 ++++ly  +
  EFC36781.1 767 SLIWGL-----------------ICSLLYSVS 781
                 333333.................333333322 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 2.2e-06
                  THHHHHHHHHHHHHHHHHHHTTCH..........................................HHH...........HHHH.S-HHHHHHHHHH CS
        CPBP    4 lllvfllalllapllEEllfRgll..........................................lql...........lqergsstlailissil 47  
                  ++  +l+ +l+  ++EEl+ R ++                                          +             l ++ ss++   i s +
  EFC36781.1  903 FVSGILYKCLYRSVTEELFERLFClllsvfifnefnltikikyiidkytnpkhsdqfrnladfekqQ-PkpiksgkavlsLPHY-SSVILATIISTI 997 
                  566788999999***********96666666666666666666666666666666655555555551.0455554444334444.445555555555 PP

                  HHHC....SGGGHHH.HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHH CS
        CPBP   48 Fgla....Hlpngps.vllaalaGlvlgylylktgsllaaillHallnl 91  
                  F++     H +++ s ++  +l ++v++y+++   ++  ++++H+  nl
  EFC36781.1  998 FSIGqparHTYTTDSfIFDKLLGSFVYSYMFVVQEKVELCMVAHFTKNL 1046
                  6655111155554444788888889*********99*********9998 PP

>> ThrE  Putative threonine/serine exporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0      0.89     8e+03      55      87 ..     188     220 ..     180     232 .. 0.73
   2 ?   11.0   0.0   2.3e-05       0.2      73     158 ..     728     816 ..     707     821 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 0.89
        ThrE  55 sittvrrvrsrgvnleklsevnelsreiaagei 87 
                  +t  +r+++ ++nl     +n++ r+++  ei
  EFC36781.1 188 LLTSKKRICEEEINLAEAVSMNAMERSLVLMEI 220
                 556667789999999999888888877766555 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 2.3e-05
        ThrE  73 sevnelsreiaageisleeaeerLdeIerskpryprwlvvlaaglaaaafallfgg...dwidflvaflagllggllrlllakrglnsf 158
                 se ne+ r+ ++  i l+  ++++ e+e+ ++++ +++v l++gl++  +  + +     +  +lva++ ++++++  +l++ ++++s+
  EFC36781.1 728 SEYNEIQRDYSEALIVLDLQKQKIIELENYSNSFHPLVVSLIWGLICSLLYSVSQVevsAIRPILVATFYTIVVYFGVQLTRAMKFYSY 816
                 6789999*****************************************99998888333455567777777777777777777766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1054 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1845  (0.102906); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.88u 0.34s 00:00:01.22 Elapsed: 00:00:00.53
# Mc/sec: 6037.16
//
Query:       EFC36782.1  [L=568]
Description: hypothetical protein NAEGRDRAFT_82117 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-08   34.1   9.7    3.3e-08   33.5   9.7    1.3  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.5   9.7   1.8e-12   3.3e-08       2      39 ..      24      60 ..      23      61 .. 0.95

  Alignments for each domain:
  == domain 1  score: 33.5 bits;  conditional E-value: 1.8e-12
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                aC  Crk+++KCd++ P C +Ck +++eC+ y+e+ kr
  EFC36782.1 24 ACFACRKGHRKCDRHLPGCNECKLKGKECK-YPEPMKR 60
                8*****************************.*999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (568 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       632  (0.0352502); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 3124.07
//
Query:       EFC36783.1  [L=147]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0054   16.6   0.4      0.011   15.6   0.1    1.7  2  DUF3198   Protein of unknown function (DUF3198)


Domain annotation for each model (and alignments):
>> DUF3198  Protein of unknown function (DUF3198)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.25   4.5e+03      32      41 ..      58      67 ..      55      72 .. 0.46
   2 !   15.6   0.1     6e-07     0.011       9      42 ..      82     115 ..      80     124 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.25
                H-SHHHHHHH CS
     DUF3198 32 lGssYqqrLe 41
                ++s + +  e
  EFC36783.1 58 FDSNFSELNE 67
                4444444333 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 6e-07
                 HHHS--HHHHHHHHHHHHHHHHHH-SHHHHHHHH CS
     DUF3198   9 lInSdSKstFvknlkeLekiarklGssYqqrLee 42 
                 lInS SK   vk l++Le    k+ + Y+ r + 
  EFC36783.1  82 LINSSSKFNTVKGLNKLEWCRAKHEENYKIRVDK 115
                 7*****************************9886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (147 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       665  (0.0370907); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.58
# Mc/sec: 766.67
//
Query:       EFC36784.1  [L=307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.6e-17   63.0   0.9    3.9e-17   62.4   0.9    1.2  1  CRAL_TRIO  CRAL/TRIO domain


Domain annotation for each model (and alignments):
>> CRAL_TRIO  CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.4   0.9   2.2e-21   3.9e-17       5     159 .]     124     277 ..     121     277 .. 0.88

  Alignments for each domain:
  == domain 1  score: 62.4 bits;  conditional E-value: 2.2e-21
   CRAL_TRIO   5 eggkvgihgrDkegrpvlylrlgrfdpk..klsleelvralvlvlerllkeleedgqvegvtvviDlkglslskmlwkpisllkkilkilqdnyperlg 101
                 ++g+ +  g+Dk +rp++y+ +++  +   k +le     +v+ +e l+k +++  +v ++  + D++g+++s  l   ++++k++   l  +y erl 
  EFC36784.1 124 KSGFLFHYGYDKWNRPIVYIDMKKDSTPmtKENLELKYLTFVYYTENLIKRMPK--NVYQISWILDVTGANVSISL---VKQMKDTFLDLGIYYCERLA 217
                 67888899***************8888854444445555667889****99999..***************99888...9999999999999******* PP

   CRAL_TRIO 102 kilivnaPklfkfafklvkpfldektreKikfvspsntea...tlekyidpeqlpkelGGt 159
                  +++vn+  +++ ++k+v++fl ++t e+ ++  ++++++   +l++++d+ +l k + Gt
  EFC36784.1 218 LAFVVNVTMSINLIWKFVSSFLAKQTVERYHVF-TKDCKKlrdALHHFFDEGSLLKDFHGT 277
                 *******************************99.556655777************999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       617  (0.0344135); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 2119.94
//
Query:       EFC36785.1  [L=233]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.17   11.7   0.0       0.38   10.6   0.0    1.4  1  RNA_lig_T4_1  RNA ligase


Domain annotation for each model (and alignments):
>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   2.1e-05      0.38      48     140 ..      65     173 ..      57     185 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 2.1e-05
  RNA_lig_T4_1  48 teKenGclilisalsdgklvvaSkhsl.................eaeshaevgerllekklekegkte...............eeLaeelleknlTa 112
                   + K++G++i+ s+ ++ + v  S h                              ll          +               +    ++  knlT 
    EFC36785.1  65 SMKQDGFFIIASGPTQIHRVDSSYHVNsfkldipmkwlsmgsveR------CVGGLLT---------AqynlmnlvysggelgKAYIVQVNLKNLTQ 146
                   678888888888555555555555544444444444442222221......2222222.........02222333334422224444447889**** PP

  RNA_lig_T4_1 113 vfElcddsfeehivaypeekagLyLhgl 140
                   ++E+++   + h++ ++e+ ++L L+++
    EFC36785.1 147 IAEVISLGANSHVIDVHED-SELGLLHI 173
                   ****************955.55555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (233 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       403  (0.0224776); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 1595.50
//
Query:       EFC36786.1  [L=682]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00036   20.1   0.5    0.00074   19.0   0.5    1.6  1  F-box_5   F-box


Domain annotation for each model (and alignments):
>> F-box_5  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.5   4.1e-08   0.00074       2      32 ..      71     101 ..      70     104 .. 0.95

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 4.1e-08
                 ---GGGTHHHHHCC---HHHHHHHTTS-HHH CS
     F-box_5   2 sgfpDeVlecVlpyitsprDRnAvSlVCkrW 32 
                 s+++D+ ++ ++++++  +DR +  lVCk W
  EFC36786.1  71 SQIVDDCWQIIFDFVEKIEDRKSMILVCKHW 101
                 6899*************************** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (682 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       608  (0.0339115); expected 358.6 (0.02)
Passed bias filter:                      277  (0.0154498); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.26s 00:00:00.89 Elapsed: 00:00:00.44
# Mc/sec: 4637.58
//
Query:       EFC36787.1  [L=472]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.6e-06   27.0   0.6    5.6e-06   27.0   0.6    2.0  3  CDP-OH_P_transf  CDP-alcohol phosphatidyltransferase
    0.00045   20.6   0.0    0.00066   20.0   0.0    1.2  1  PhyH             Phytanoyl-CoA dioxygenase (PhyH)
  ------ inclusion threshold ------
      0.024   14.8   0.3      0.024   14.8   0.3    2.1  3  DUF4418          Domain of unknown function (DUF4418)


Domain annotation for each model (and alignments):
>> CDP-OH_P_transf  CDP-alcohol phosphatidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.6   9.4e-10   5.6e-06       2      66 .]      49     121 ..      48     121 .. 0.78
   2 ?   -3.3   0.4       2.7   1.6e+04      27      41 ..     142     157 ..     123     163 .. 0.38
   3 ?   -3.2   0.2       2.6   1.5e+04      20      27 ..     203     213 ..     196     243 .. 0.53

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 9.4e-10
                      -HHHHHHHHHHHHHHHHHGGGS-H.........HHHHHHHH.HHHHHTTHHHHHHHHTT---HHHHHHHHHHH CS
  CDP-OH_P_transf   2 lPnaiTllrlllsvlailllltyyp.......lvlaillll.iasltDalDGklARrlnqvstlGkllDslaD 66 
                       +n++ +lr++++v+a++ l++ +          + i +l+  ++l+D++DG lAR ++q+s +G   D laD
       EFC36787.1  49 YANIVDYLRIVMVVVALIALIVNDEmnlgcnwSSISISVLVfGSVLLDWVDGPLARNFGQSSVMGCGWDWLAD 121
                      58999*******99999777555558888877444444444377899*************666**99998888 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.7
                      .HHHHHHHH.HHHHHT CS
  CDP-OH_P_transf  27 lvlaillll.iasltD 41 
                      + l  +ll  + + t+
       EFC36787.1 142 FKLFTVLLTaVEISTG 157
                      2222222222334444 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.6
                      GGGS-H..... CS
  CDP-OH_P_transf  20 llltyyp...l 27 
                      l++t+yp   +
       EFC36787.1 203 LVNTLYPitvF 213
                      45555553220 PP

>> PhyH  Phytanoyl-CoA dioxygenase (PhyH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.0   1.1e-07   0.00066      55     203 ..     302     440 ..     253     446 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1.1e-07
                 E...CCCHHCHHHHTTHHHHHHHHHHHHTSCEEEEEEEEEEEEE...EEE-TTTCB-EEEEE-SGGGSTEESGCCEEEEEEESS-B-TTBT-EEEETTG CS
        PhyH  55 l...eksinkvghflhprkvadlvrailgqdvyvaavlqsmyqd...ifkqpkiGgevqpwHqDstflptdpeesvvgvwialedateenGclrfiPGS 147
                     + s+++  h l   ++ d+v+++++++ ++    q+++     ++ +pk G+ +q+wH D+        e+v ++ i l+d+te+nG ++fi G 
  EFC36787.1 302 YnngKISPVFENHPLQK-EFHDWVKSLVKSNWLD---EQDRIILsygFITAPKNGNVTQDWHFDY-------GENVSNLFIPLCDVTEKNG-TQFIRGP 388
                 13346888888888888.*************998...56666556899999999**997777775.......48999*************9.7999997 PP

                 GGS-CCGTCCHHCSGCCTTSCCCTTTGHGSCEEEE.BTTTEEEEEETTSEEEE-TB CS
        PhyH 148 HkweegplrrrlpeddteaeddeakkedeeeavpvevkaGdavlfhgrllHgsgaN 203
                  +++         +++ ++e+ +++k++  ++ +v++ka  ++  h+ + H++ aN
  EFC36787.1 389 LRQDMP----PGEYFPRPFEIMTEEKSECLQVCQVVCKAFNLLKLHPGVCHRGIAN 440
                 665333....4556666666666677777777777777777777777777776665 PP

>> DUF4418  Domain of unknown function (DUF4418)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.3     4e-06     0.024      31      76 ..      46      90 ..      27     100 .. 0.94
   2 ?   -2.7   0.1       1.1   6.7e+03      29      47 ..     112     130 ..     101     165 .. 0.56
   3 ?   -2.6   0.1         1   6.1e+03      13      27 ..     368     382 ..     366     422 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4e-06
     DUF4418 31 ChytgqaelgvGivllvlgllalfvkkkklrrglsiavillgvlvi 76
                C y ++++ ++ iv++v++l+al+v+++ ++ g +++ i ++vlv+
  EFC36787.1 46 CLYYANIVDYLRIVMVVVALIALIVNDE-MNLGCNWSSISISVLVF 90
                ***************************9.**************986 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.1
     DUF4418  29 MkChytgqaelgvGivllv 47 
                 M C +   a +++ + l++
  EFC36787.1 112 MGCGWDWLADILTQLCLAI 130
                 6666655555544333333 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1
     DUF4418  13 fvlapvCekkeelgk 27 
                   ++p C  +e++g+
  EFC36787.1 368 NLFIPLCDVTEKNGT 382
                 578899999888754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (472 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       621  (0.0346366); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.26s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 3116.18
//
Query:       EFC36788.1  [L=693]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-25   90.4   0.7    8.3e-25   87.5   0.5    2.5  2  Copine    Copine
    1.2e-11   44.8   0.0    2.9e-11   43.5   0.0    1.6  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> Copine  Copine
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.14   1.3e+03     170     190 ..     408     428 ..     377     438 .. 0.73
   2 !   87.5   0.5   9.3e-29   8.3e-25       1     214 [.     473     691 ..     473     693 .] 0.80

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.14
      Copine 170 akRdivqfVdfrdlksnasak 190
                  +  i+qf ++++++ n+++k
  EFC36788.1 408 KHSGIFQFLHVTEFMGNEESK 428
                 44579**********966544 PP

  == domain 2  score: 87.5 bits;  conditional E-value: 9.3e-29
      Copine   1 sLHyispeqpneYekallsvgeilqaydsdklipafGFGaklpsdaevsdefvl....nfneenkevegiegvleaYrealpnlql......ygP.Tn. 87 
                 sLH+ +  ++n Ye++l + g++++ y  d +++ +G+ a +   a+  +++++    ++  ++ + +g e  +++Yr+ l+n+          P Tn 
  EFC36788.1 473 SLHFQG--NKNTYERVLKTFGRVCECY-CDTEFSMYGYSA-IQRTASSPQQQPFftldDMYINSMKFTGYERAINTYRTGLQNIDFdelsnvRNPkTNl 567
                 677766..89*****************.5889********.55544433333331112344557899****************9642222223453332 PP

      Copine  88 ......fapviekvakiaeasakeasqYfvLliitDGvvtdmketidaivaAsklplSiiivGvGdadfekmreldddd.alkssdgriakRdivqfVd 179
                       f  +i++v++++e+   +++ Y+vL+i+  G   ++++t+da+v+ s+ p+Siii+GvG   f++ + l +++   + s+g+ + R +v+fV 
  EFC36788.1 568 nfrnddFYHLINHVSNNVEE---NEKTYKVLVIMINGDDIELQRTVDALVDCSSKPISIIILGVGSCSFSSCKILFSNNqFQHGSTGKKPIRCNVKFVR 663
                 22222277899999999998...999************************************************999984556699************* PP

      Copine 180 frdlksnasakeaalakavLaeiPkqlkaylelrk 214
                 ++d+++       +  +++La+iPkq+++y++++k
  EFC36788.1 664 LQDVNE-------NAYSKILADIPKQFVEYYQINK 691
                 ****99.......55689*************9886 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.5   0.0   3.3e-15   2.9e-11       9      95 ..     301     390 ..     297     397 .. 0.88

  Alignments for each domain:
  == domain 1  score: 43.5 bits;  conditional E-value: 3.3e-15
                 EEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESC....HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTH CS
          C2   9 eAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvWnekftfevae....leeakLeveVfdndrlskddfiGkveiplstllsge 95 
                 +A +L +kd++  sdp++++  d+k++++++vikn l+P+Wn +f+++ ++    + +++L+v+++d+d +s++d+iG++ + + ++l+g+
  EFC36788.1 301 RAMGLDRKDIFALSDPFIVILNDEKEIFRSEVIKNMLDPEWN-SFSISSSKlcenDYNKQLKVRCYDWDLISSNDLIGEFYFTILQVLNGN 390
                 7899*************************************6.5666666677789*************************9988866665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (693 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       631  (0.0351944); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 3964.09
//
Query:       EFC36789.1  [L=912]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.3e-27   94.3   0.6    6.3e-27   94.3   0.6    2.1  2  E1-E2_ATPase     E1-E2 ATPase
    2.2e-12   47.1   0.1    2.2e-12   47.1   0.1    2.4  3  Cation_ATPase_C  Cation transporting ATPase, C-terminus
    1.4e-11   45.1   1.0    6.3e-10   39.7   1.0    2.9  1  Hydrolase        haloacid dehalogenase-like hydrolase
      4e-08   33.3   7.0    1.8e-05   24.6   0.8    3.7  3  Hydrolase_3      haloacid dehalogenase-like hydrolase
    1.9e-07   30.7   0.0    7.6e-07   28.7   0.0    2.1  1  Cation_ATPase_N  Cation transporter/ATPase, N-terminus
     0.0077   16.3   0.0      0.019   15.0   0.0    1.7  1  Cation_ATPase    Cation transport ATPase (P-type)
  ------ inclusion threshold ------
       0.82    8.4   4.1          2    7.2   4.1    1.6  1  DUF2079          Predicted membrane protein (DUF2079)
       0.84   10.0   2.9        0.5   10.8   0.1    2.1  2  DUF2628          Protein of unknown function (DUF2628)
        1.3    9.1   6.9        1.1    9.4   0.6    3.3  3  DUF3671          Protein of unknown function


Domain annotation for each model (and alignments):
>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.9       2.1   4.2e+03     125     154 ..      54      80 ..      28      85 .. 0.47
   2 !   94.3   0.6   3.2e-30   6.3e-27       4     151 ..     107     274 ..     105     279 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.1
                   HHHHHHHHHHHS-STTTSSTTHHHHHHHHH CS
  E1-E2_ATPase 125 vvlliallvflialllgkslaeallralal 154
                   ++l+++ ++++i+      ++ ++++++ +
    EFC36789.1  54 LMLFVVGILYFIW---DSLWNAIVVFSCII 80 
                   2233333333333...22222333334444 PP

  == domain 2  score: 94.3 bits;  conditional E-value: 3.2e-30
                   --EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.....EEE-TTTS---S-EE-............G-TTEE-TT-EEEE-EEEE CS
  E1-E2_ATPase   4 pptakvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa.....evdesaLTGEslpvek............ekgdmvfsGtvvvsgeaka 83 
                   ++t++v+r+g + +i +++lvpGD++ ++ g++ paD+r+ + ++     +vdes+LTGEs+ + k            + ++ + +Gt++++g+  +
    EFC36789.1 107 SKTCTVRRNGILSNISVSDLVPGDVINFNGGQILPADVRLYNYENrqisvQVDESILTGESMVCNKhgnnissnedmsKCENILLTGTSIKKGKGFG 203
                   679**************************************954444557************************999999***************** PP

                   EEEE-T.TTSTTTTTSTTS----..----HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHH CS
  E1-E2_ATPase  84 vVtatg.edtelgkiarlveeak..skktplqkkldklgkvlvpvvlliallvflialllgkslaeallra 151
                   +V+++g e+t lg i +l+ ++    kkt+lqk +++l+k+l+++++++a ++++ +l+++  + e+l ++
    EFC36789.1 204 IVVNVGcENTGLGNILKLLGKSMekDKKTELQKTMKELAKYLTIISIVMASIIVISLLIKKLHVPESLANI 274
                   *****966788********87765599***************************99999887776666655 PP

>> Cation_ATPase_C  Cation transporting ATPase, C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.2      0.58   1.1e+03      52      59 ..      66      73 ..      45     109 .. 0.59
   2 ?   -3.0   0.0       2.5     5e+03     163     174 ..     247     258 ..     226     266 .. 0.51
   3 !   47.1   0.1   1.1e-15   2.2e-12       2      93 ..     673     764 ..     672     808 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.58
  Cation_ATPase_C 52 rriliqgl 59
                     +++l++++
       EFC36789.1 66 WDSLWNAI 73
                     22233333 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.5
  Cation_ATPase_C 163 lialllalvvll 174
                      +i++++a+++++
       EFC36789.1 247 IISIVMASIIVI 258
                      222222222222 PP

  == domain 3  score: 47.1 bits;  conditional E-value: 1.1e-15
  Cation_ATPase_C   2 lplsaiqiLwinLvtDllpalaLaleppekdimkrpPrkkkepliskkmlrriliqgllqalvtllvffltll.......lfgisekenklssn 88 
                       pl ++qi++++L++D+ +a++++le++e+ +mk+pPr ++++ ++k+++ +i+i ++ +++ ++  ++l+++       l g+s+      ++
       EFC36789.1 673 IPLEPMQIILLELFSDIGAATTFVLEEEEETLMKNPPR-TEKNFVDKSFIYHIIIGSISLFATVFSSYMLGVFvlspmygLEGSSH------QE 759
                      79************************************.9**************************99999985555332112222......34 PP

  Cation_ATPase_C  89 yaqtm 93 
                      yaq +
       EFC36789.1 760 YAQNW 764
                      45544 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.7   1.0   3.2e-13   6.3e-10       2     209 ..     275     597 ..     274     598 .. 0.62

  Alignments for each domain:
  == domain 1  score: 39.7 bits;  conditional E-value: 3.2e-13
                 SEEEEESBTTTBCHHHHHHHHHHHH...................CHHHHHHHHHH.................HHCHHHHHHHHHHHHHHHHH.HHHHHE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxx...................xxxxxxxxxxx.................xxxxxxxxxxxxxxxxxxxx.xxxxxx RF
   Hydrolase   2 ktvvfDkdGTLttgepsvedvivsa...................alalaaaletg.................sehpigkalvaaakarsgal.tgfatf 63 
                 + ++ Dk+GT+t+      ++i+ +                   +                              p+ k + ++ +  s +  +gf + 
  EFC36789.1 275 THIITDKTGTITKNC---LQLIQVNqvdkdgnvdlvydtkkqmeK---------NnwiiewllsgytevgadLADPFEKSVSEELERCSNQSwKGFLK- 360
                 568889999999444...444444423344444443333232220.........13333444443333335555555555555555553333344444. PP

                 TTTE................................HHHHTHHHHHHHHHCHHHHHHHHHHHHHHCHHHHHH........................... CS
                 xxxx................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........................... RF
   Hydrolase  64 igrg................................ayaigkpewltaldippdlgaaigsaqsqgrtvall........................... 103
                    +                                + ++g                                                          
  EFC36789.1 361 ---NrtensysivdempfdhtkgfatlilssgeskfVTHKG------------------------------Ipermitnclfyqvsneseqvpmteevr 426
                 ...01222334444444444444445533333333333333..............................0444444444444444444444555556 PP

                 ...........................TTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHHTT......GGGESEEEEHHCE CS
                 ...........................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxx RF
   Hydrolase 104 ...........................qaralavftiadplkvkpeaaeavasLkaagievvlltgdnpetaeraanqlG......ddyfdaviasdie 169
                                            q   + ++ + dp  ++ +++ea+   k agi+v++++gd+ +t+ +aa+++G      +d +  +++++++
  EFC36789.1 427 erilsflevettkgmrviclckdneqsQMVFVSLLSFTDP--LRSGVKEAISDCKNAGIKVIIVSGDHTNTVISAARECGllssvkQDLLVEEHEHSED 523
                 6666677788999999999999999877788888888899..**************************************9999973333333333333 PP

                 S....STTT...............................SHHHHHHHHHHHT.STGGGEEEEESSHHHHHHHHHT CS
                 x....xxxx...............................xxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 170 t....vakp...............................spegkvaaireLq.gkpeevamVGDgvnDaaalaaA 209
                 +       +                                p+ k  +++ L+  k+ +v++ GDg+nD++a+ +A
  EFC36789.1 524 EdielE--AsllsnrqsvciegkdvndkmdvdsvcaisraTPQNKYDLVEMLKeQKGYKVLVSGDGMNDVPAISNA 597
                 335552..13356666667777788888888999999999************9778999*************9887 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.4      0.22   4.3e+02     140     205 ..     216     281 ..     120     285 .. 0.64
   2 !    9.1   0.0   0.00051         1      18      53 ..     469     504 ..     459     510 .. 0.85
   3 !   24.6   0.8   8.9e-09   1.8e-05     205     247 ..     580     622 ..     564     630 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.22
                  CSESEEE.EES-HHHHHHHHHHHHHHCTTTEEEEEESTTEEEEEETT-SHHHHHHHHHHHCT--GGG CS
  Hydrolase_3 140 eeiakil.ilkdkekldelekelksklnklltitssskgyleimpkgvsKgtalkklakelnislee 205
                   +i k+l  + +k+k +el+k++k++ +  lti+s    ++ +++  ++K +  + la+   i  ++
   EFC36789.1 216 GNILKLLgKSMEKDKKTELQKTMKELAKY-LTIISIVMASIIVISLLIKKLHVPESLANITHIITDK 281
                  46788888777788888888888888654.5888888888888888888888888888777776665 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00051
                  HHHHHHHHHHHHTTSEEEEE-SS-HHHHHHHHHHCC CS
  Hydrolase_3  18 ektkeaikklkekgikvviATGRslravlpvleelg 53 
                     keai  +k++gikv+i +G ++ +v++ ++e g
   EFC36789.1 469 SGVKEAISDCKNAGIKVIIVSGDHTNTVISAARECG 504
                  5689********************999999888776 PP

  == domain 3  score: 24.6 bits;  conditional E-value: 8.9e-09
                  GEEEEESSGGGHHHHHHSSEEEEETTS-HHHHHHSSEEE--GG CS
  Hydrolase_3 205 eviafGDgeNDieMLeaaglgvAmgnaseevkkaAdyvtksnn 247
                  +v++ GDg+ND++ ++ a +g+Am+++ + +k+aA  ++ + n
   EFC36789.1 580 KVLVSGDGMNDVPAISNATVGIAMRSGVDLAKEAAEIIIMDDN 622
                  79999********************************998776 PP

>> Cation_ATPase_N  Cation transporter/ATPase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.0   3.8e-10   7.6e-07      18      68 ..       6      62 ..       2      63 .. 0.88

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 3.8e-10
  Cation_ATPase_N 18 enGLtqaeaaerlkkyGpNel......kekkkkslwvkllkqftnplvilLlvaalv 68
                      nGL+++++++ ++k+G+N +      k   k s+w+ ++++++ p++++L+v++++
       EFC36789.1  6 DNGLDDEQVKQQRQKFGENDIytklveKSSSKISFWKVFISEVREPMILMLFVVGIL 62
                     69*****************99555554566799*********************997 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   9.7e-06     0.019      38      89 ..     359     408 ..     335     410 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 9.7e-06
  Cation_ATPase  38 dteelreetkkvqeipFnssrKrmsvvlklepekkvrlyvKGApeiilkrCt 89 
                     +++ ++++ +v e+pF+ ++ +++ +l+    ++  ++ KG pe+++ +C 
     EFC36789.1 359 LKNRTENSYSIVDEMPFDHTKGFATLILSS--GESKFVTHKGIPERMITNCL 408
                    56789999*********************6..5888999************5 PP

>> DUF2079  Predicted membrane protein (DUF2079)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   4.1   0.00099         2     133     189 ..      32      85 ..      26      88 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00099
     DUF2079 133 rrkwllllvlilllllvredlslvvvilglwlilrerkrrkiglillllglawvilv 189
                 +++  ++ ++ ++++ vre ++l+++++g++ +++   + +  +i+++ +++ ++lv
  EFC36789.1  32 EKSSSKISFWKVFISEVREPMILMLFVVGILYFIWD--SLW-NAIVVFSCIILMVLV 85 
                 56667788999*************************..466.778888888887776 PP

>> DUF2628  Protein of unknown function (DUF2628)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   0.00025       0.5      20      56 ..      48      84 ..      10      94 .. 0.77
   2 ?   -3.4   0.4       6.3   1.3e+04      48      63 ..     247     266 ..     241     278 .. 0.49

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00025
     DUF2628 20 irlsfnvwAfffgfiwLlyrklwlkalvllviavavs 56
                +r  +  + f++g++++++  lw + +v+  i + v 
  EFC36789.1 48 VREPMILMLFVVGILYFIWDSLWNAIVVFSCIILMVL 84
                455688888********************99887764 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 6.3
     DUF2628  48 llviavavsvvlavl....g 63 
                  + i +a+ +v+++l    +
  EFC36789.1 247 IISIVMASIIVISLLikklH 266
                 33344444444443344444 PP

>> DUF3671  Protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.21   4.1e+02      25      64 ..      29      66 ..       8     112 .. 0.75
   2 ?    9.4   0.6   0.00054       1.1      55     112 ..     213     265 ..     172     267 .. 0.71
   3 ?   -0.7   0.1       0.7   1.4e+03      35      60 ..     711     735 ..     679     781 .. 0.48

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.21
     DUF3671 25 lakkknndkkkfkkkvlkkyglllilpvllpliglivpil 64
                   +k+++k +f+k ++ +   ++il+  l+++g++ +i 
  EFC36789.1 29 KLVEKSSSKISFWKVFISEVREPMILM--LFVVGILYFIW 66
                444558888899998888877777765..56667666665 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00054
     DUF3671  55 pliglivpilfeakskkslkkkelevlatsieklytiffiilvviillvliYiliKvi 112
                   +g i+ +l      ks++k+++  l++++++l +++ ii++v+  +++i +liK++
  EFC36789.1 213 TGLGNILKLLG-----KSMEKDKKTELQKTMKELAKYLTIISIVMASIIVISLLIKKL 265
                 44555666662.....345555556788899999999999999999999999999975 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.7
     DUF3671  35 kfkkkvlkkyglllilpvllpligli 60 
                 + k++v k + + +i+ + ++l +++
  EFC36789.1 711 TEKNFVDKSFIYHIIIGS-ISLFATV 735
                 334444444444444222.2222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (912 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1069  (0.0596241); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.92u 0.34s 00:00:01.26 Elapsed: 00:00:00.54
# Mc/sec: 5125.90
//
Query:       EFC36790.1  [L=214]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1386  (0.0773049); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1288.92
//
Query:       EFC36791.1  [L=458]
Description: hypothetical protein NAEGRDRAFT_82122 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.07   13.8   0.5       0.23   12.2   0.5    1.8  1  VCX_VCY      Variable charge X/Y family
       0.24   11.7   3.3          1    9.7   0.4    2.9  3  FKS1_dom1    1,3-beta-glucan synthase subunit FKS1, domain-1


Domain annotation for each model (and alignments):
>> VCX_VCY  Variable charge X/Y family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.5   2.5e-05      0.23      23     102 ..     161     238 ..     153     252 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.5e-05
     VCX_VCY  23 sseaspstpkkktpkvgkrGkagpgGrggkkraagkkmaavgapeagsGpaapGpskppsqelppqelpkeepvsepdpl 102
                 ss  +p tp kk +k ++ G       ++kk++  k +a+v +  + s  ++  p +  +     +    ++p +e+  l
  EFC36791.1 161 SSSNTPNTPCKKKTKRAQTGSINFV-SNNKKGTNKKWIASVNTTVSSSSSSPTNPLNTTTTT-TTTTTNSTQPTAEQSFL 238
                 78899*************9987655.567888888889999988888777777776655443.34445566666666555 PP

>> FKS1_dom1  1,3-beta-glucan synthase subunit FKS1, domain-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1     0.066   5.9e+02      51      80 ..      25      54 ..       4      80 .. 0.63
   2 ?    9.7   0.4   0.00012         1      49      90 ..     212     255 ..     192     297 .. 0.70
   3 ?   -0.9   0.1      0.21   1.9e+03      53      91 ..     276     314 ..     258     321 .. 0.64

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.066
   FKS1_dom1 51 eleeileekvseaaaseeeesfLkkvitPl 80
                  ++  ++++ ++++++++  +++++++P 
  EFC36791.1 25 TTNASSSSTTIRNNSNNRSRRYIDNIVHPQ 54
                233334444445778889999******995 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00012
   FKS1_dom1  49 lkeleeil..eekvseaaaseeeesfLkkvitPlyevlrkqeae 90 
                 ++ l+++   +++++++++ + e+sfL+++i+P+ +++r ++ +
  EFC36791.1 212 TNPLNTTTttTTTTTNSTQPTAEQSFLQQLINPMSSMIRPNTNN 255
                 3334443300444445777889****************876554 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.21
   FKS1_dom1  53 eeileekvseaaaseeeesfLkkvitPlyevlrkqeaek 91 
                 ++ l ++++  ++++++++ ++++++Pl + + ++++++
  EFC36791.1 276 HNHLVSSMNPFQHQQHNMNTIQSMLHPLSNNIYQSNVQN 314
                 344455556677777777778888888887775555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (458 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1458  (0.0813208); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.49
# Mc/sec: 2836.95
//
Query:       EFC36792.1  [L=146]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-17   63.4   0.8    3.6e-17   63.1   0.8    1.1  1  DUF2262   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF2262  Uncharacterized protein conserved in bacteria (DUF2262)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.1   0.8     2e-21   3.6e-17      23     143 .]      34     144 ..      21     144 .. 0.78

  Alignments for each domain:
  == domain 1  score: 63.1 bits;  conditional E-value: 2e-21
     DUF2262  23 kgkkisllleld..edekeikkalkvlkklienqkewdkkvkdyaakelldland.WleddeedeelkaeeiteedFikrieldsisieeegeftlyfd 118
                 + kk+++++el+  ed +  ++ l+++++++++ + +       a++el++l nd W e        + ee+++edF+kr++l+s+++++  +  +yfd
  EFC36792.1  34 LLKKVHINIELEndEDPSIVDSLLTIANDMLQKLDVYA----AKATEELYELFNDeWNE--------EGEEVSKEDFAKRLKLESLIVKSS-SRLVYFD 119
                 55777777777531333333444666666666555554....55889*****9995663........2568******************99.6779*** PP

     DUF2262 119 dgdlFaghsiivsgningelenadi 143
                 dg+lF gh+i v+++ +g++e+adi
  EFC36792.1 120 DGELFCGHVIEVNIDNEGNVESADI 144
                 ***********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       602  (0.0335769); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.36u 0.23s 00:00:00.59 Elapsed: 00:00:00.39
# Mc/sec: 1117.89
//
Query:       EFC36793.1  [L=444]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-25   88.6   6.0    8.3e-12   44.7   0.0    6.3  6  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.14   12.4   0.4          2    8.7   0.1    2.6  2  IlvC      Acetohydroxy acid isomeroreductase, catalytic domai


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   0.1   1.3e-11   1.1e-07       2      49 .]     108     155 ..     107     155 .. 0.95
   2 !   44.7   0.0   9.2e-16   8.3e-12       1      44 [.     157     200 ..     157     201 .. 0.98
   3 ?   -0.7   0.0      0.13   1.2e+03      22      36 ..     215     229 ..     214     234 .. 0.83
   4 !    6.0   0.1    0.0011        10       3      45 ..     248     301 ..     246     313 .. 0.74
   5 ?    2.2   0.0     0.017   1.5e+02       1      20 [.     341     360 ..     324     385 .. 0.75
   6 ?   -2.0   0.1      0.36   3.2e+03      10      20 ..     406     416 ..     399     434 .. 0.53

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 1.3e-11
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + i+ e+vkk+g+ l   s +Lk++ +iv  Av+qng al +a+ +Lr
  EFC36793.1 108 ERICEEIVKKDGLKLAMMSLNLKSNENIVRNAVQQNGMALQFAHYKLR 155
                 6799****************************************9987 PP

  == domain 2  score: 44.7 bits;  conditional E-value: 9.2e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 +rEiv  a+++ng+al+y+ +eL++  eivl+Av qng+a+sya
  EFC36793.1 157 NREIVCLALDQNGMALQYAAKELRQELEIVLRAVSQNGSAFSYA 200
                 8******************************************8 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.13
     DUF4116  22 eLknDkeivlkAvkq 36 
                 +Lk D +++  Avk+
  EFC36793.1 215 SLKLDPQVIETAVKS 229
                 588899999999986 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.0011
     DUF4116   3 EivleavkkngsalkylseeLknDk...........eivlkAvkqng.talsyas 45 
                  ++l+++++ g+++  +s +L+ D            e+v k++ + +  +l+++s
  EFC36793.1 248 NVALQCIRN-GNSIFSVSVRLREDPefktladqarnEFVQKIILSKSsQFLNHVS 301
                 677888887.99999********99666666666666677776655424667666 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.017
     DUF4116   1 DrEivleavkkngsalkyls 20 
                 DrE vl+ ++k ++ l + +
  EFC36793.1 341 DRERVLKSIRKIPLTLVFMD 360
                 88889999999988776654 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 0.36
     DUF4116  10 kkngsalkyls 20 
                 + n ++ kyls
  EFC36793.1 406 EENIEIVKYLS 416
                 44444455554 PP

>> IlvC  Acetohydroxy acid isomeroreductase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.1   0.00022         2      31      78 ..     165     212 ..     163     288 .. 0.80
   2 ?    0.9   0.0     0.057   5.1e+02      65      94 ..     412     441 ..     392     444 .] 0.83

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00022
                 HHHTT--HHHHHHHHTHHHHHHHHHHHHHHHHHHHHHS-HHHHHHHHH CS
        IlvC  31 lveaGyspelAyfeclhelklivdliyegGiakmresiSdtaeygdlt 78 
                 l ++G+  ++A +e+ +el+ +++ ++++G a  +  + +t + +  +
  EFC36793.1 165 LDQNGMALQYAAKELRQELEIVLRAVSQNGSAFSYAMCHRTKKTRSRR 212
                 6689**************************998888888887765433 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.057
                 HHHS-HHHHHHHHHHHHHHS-HHHHHHHHH CS
        IlvC  65 resiSdtaeygdltagprviteevkeemke 94 
                  + +S+t  +g+++ +++vi+   k+  k+
  EFC36793.1 412 VKYLSTTKIVGQYEFMEKVIRIILKKMTKK 441
                 678999999********9998888777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (444 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       566  (0.031569); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2694.64
//
Query:       EFC36794.1  [L=800]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-08   33.3   0.0    8.7e-06   26.3   0.0    3.2  3  RCC1      Regulator of chromosome condensation (RCC1) repeat
    4.2e-07   30.2   8.5    0.00094   19.4   1.1    4.1  3  BTB       BTB/POZ domain
    1.7e-06   27.7   3.7       0.14   12.0   0.0    4.4  4  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.33     2e+03      33      48 ..      96     111 ..      86     113 .. 0.76
   2 ?    2.7   0.0     0.033     2e+02       1      11 [.     208     218 ..     208     222 .. 0.88
   3 !   26.3   0.0   1.5e-09   8.7e-06       2      50 .]     270     319 ..     269     319 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.33
                 TTS-EEEEEEETTEEE CS
        RCC1  33 sgnrvvkvacGddhtv 48 
                 ++ ++vk+++G++ ++
  EFC36794.1  96 DASKIVKISSGGHDSL 111
                 4459*******98666 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.033
                 TTEEEEEE--G CS
        RCC1   1 dGrVysWGrnd 11 
                 dG Vys G+n 
  EFC36794.1 208 DGLVYSLGKNY 218
                 8********96 PP

  == domain 3  score: 26.3 bits;  conditional E-value: 1.5e-09
                 TEEEEEE--GGGTTSSSS---EEE.EEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesvlv.PtkveglsgnrvvkvacGddhtval 50 
                 G+++sWG n + qLG+ ++ +  + P +++ l g ++ ++ cG++  +al
  EFC36794.1 270 GQLFSWGGNAEKQLGISSDRKYAIfPCLITALYGMKIAQADCGYSVAIAL 319
                 9******************888666*******************988876 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       2.6   1.5e+04      82      98 ..     240     256 ..     235     262 .. 0.79
   2 !   11.8   0.5   3.5e-05      0.21       1      45 [.     327     400 ..     327     472 .. 0.71
   3 !   19.4   1.1   1.6e-07   0.00094      15     109 ..     560     677 ..     545     679 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.6
                 GGHHHHHHHHHHHT-HH CS
         BTB  82 enleelLaaadllqipr 98 
                  n+e++ ++ d+l+i+ 
  EFC36794.1 240 RNVENVYQCKDYLEIHG 256
                 58999999999999975 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 3.5e-05
                 HHHHHHHTTTS-EEEEETT.....TEEEEE-HHHHHHH-HHHHHHHTST........................T CS
         BTB   1 lnelresgelcDvtlvvgd.....gkefkahkavLaarSpyFkalftsk........................e 45 
                 + el+++++l+D+ + +       +k ++ hk++L ar p + +l+ s+                        +
  EFC36794.1 327 FSELLNKETLSDLKIELYAnntseTKVIYLHKCILLARCPTLLSLILSGklnyflrkllidsqanyenyqnreN 400
                 5789999*****999888778999999****************9999986666666666666555555554442 PP

  == domain 3  score: 19.4 bits;  conditional E-value: 1.6e-07
                 EEETT...TEEEEE-HHHHHHH-HHHHHHHTST....TTTTCCCE.......EEEETTSGHHHHHHHHHHHHHSEEEC-.............CGGGHHH CS
         BTB  15 lvvgd...gkefkahkavLaarSpyFkalftsk....eieessvs.......eielddvepeafealLefiYtgeleit.............seenlee 86 
                 l+ +d   + +++ hk++L  + ++Fk  f+s+    +      +         +l  ++ e +  lL  +Y+g  + +             + +n+ e
  EFC36794.1 560 LQSKDgslNVSLPLHKVILTNSIEFFKGVFESNmeeeK----RGEmhltmdsSEDLYLFQLENVIPLLYHAYCGSNSENvqylfmdqfdanlTLSNACE 654
                 5555566678899********************43331....222434344444455677888899999999999888899*********99999**** PP

                 HHHHHHHHT-HHHHHHHHHHHHH CS
         BTB  87 lLaaadllqiprlkkaceeflkq 109
                  La+a+++  ++ k+ ce+f+++
  EFC36794.1 655 CLAVANYFASREFKASCETFISK 677
                 *******************9975 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.0   0.00097       5.8       1      23 [.       3      26 ..       3      26 .. 0.85
   2 ?   -3.3   0.1       1.5   8.8e+03       1       8 [.     100     107 ..     100     110 .. 0.88
   3 !    6.7   0.2    0.0011       6.5      10      27 ..     201     218 ..     198     224 .. 0.91
   4 !   12.0   0.0   2.4e-05      0.14       9      27 ..     261     279 ..     260     282 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.00097
      RCC1_2  1 VksvsaGd.yHscaLtedGeVlcW 23
                V++v  ++ +H+ +Lt+ GeVl++
  EFC36794.1  3 VIQVGTNNrDHFYVLTDIGEVLTF 26
                788888644************986 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.5
      RCC1_2   1 VksvsaGd 8  
                 ++++s+G+
  EFC36794.1 100 IVKISSGG 107
                 799***96 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0011
      RCC1_2  10 HscaLtedGeVlcWGsNs 27 
                 Hs+++++dG V++ G N 
  EFC36794.1 201 HSLFISSDGLVYSLGKNY 218
                 9************99995 PP

  == domain 4  score: 12.0 bits;  conditional E-value: 2.4e-05
      RCC1_2   9 yHscaLtedGeVlcWGsNs 27 
                 y+s+a t +G +++WG N 
  EFC36794.1 261 YFSLARTKTGQLFSWGGNA 279
                 89**************995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (800 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1070  (0.0596798); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.79u 0.29s 00:00:01.08 Elapsed: 00:00:00.49
# Mc/sec: 4867.09
//
Query:       EFC36795.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.4e-13   48.3   0.1    2.8e-06   27.2   0.0    3.6  3  Kelch_4   Galactose oxidase, central domain
    1.3e-12   47.7   0.1      6e-05   23.2   0.0    4.6  4  Kelch_3   Galactose oxidase, central domain
      2e-09   37.4   0.1      0.011   15.9   0.0    4.7  5  Kelch_6   Kelch motif
      3e-08   33.5   1.3     0.0049   16.8   0.1    5.0  5  Kelch_5   Kelch motif
    6.1e-06   26.0   0.2       0.42   10.7   0.0    3.9  4  Kelch_2   Kelch motif
    3.5e-05   23.3   0.8       0.74    9.4   0.2    4.3  4  Kelch_1   Kelch motif


Domain annotation for each model (and alignments):
>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.0   9.1e-05      0.27       4      40 ..      99     136 ..      96     143 .. 0.84
   2 !   27.2   0.0   9.5e-10   2.8e-06       1      43 [.     217     263 ..     217     274 .. 0.89
   3 !    5.6   0.0    0.0054        16       4      41 ..     276     318 ..     275     325 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 9.1e-05
     Kelch_4   4 ghsatsi.pdgtiylfGGrgedgtllndlylldlstnt 40 
                 + s++ + +++++y++GG +++ ++++ + +++++ n+
  EFC36795.1  99 FQSVCIDeRNNNVYVYGGFSGNRSPCSLITRFSIEGNE 136
                 44566666779***********9999999999999997 PP

  == domain 2  score: 27.2 bits;  conditional E-value: 9.5e-10
     Kelch_4   1 pRaghsatsipd.gtiylfGGrgedg...tllndlylldlstntWrr 43 
                 pRa+hsat+i + +   ++GG + +g   +++n+l+l+ ++t tW+ 
  EFC36795.1 217 PRAYHSATYIEKrDVMCVYGGKMKPGlqsGVSNELFLFHFQTHTWEN 263
                 9*********5537777899*************************85 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0054
     Kelch_4   4 ghsatsipdgtiylfGGrgedg.....tllndlylldlstntW 41 
                 gh ++ i++++i ++GG + +       l ++l++++l+ n++
  EFC36795.1 276 GHYIFKINNDNIGIIGGVSKPYseekeDLNSNLFVYNLEYNSF 318
                 799**************99998899999999999999987776 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.1    0.0017         5       2      18 ..     109     125 ..     108     137 .. 0.87
   2 !   23.2   0.0     2e-08     6e-05       2      49 .]     174     226 ..     173     226 .. 0.88
   3 !    8.7   0.0   0.00074       2.2       2      43 ..     230     276 ..     229     279 .. 0.77
   4 ?    2.4   0.1     0.066     2e+02       4      30 ..     287     317 ..     284     338 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0017
     Kelch_3   2 drlyifGGlgddgqdrl 18 
                 + +y++GG+ +++ +++
  EFC36795.1 109 NNVYVYGGFSGNRSPCS 125
                 67********9888875 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 2e-08
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWa...ei..aslppaRaghaatai 49 
                 +++y+  G+   +++++++++++dl++++++   +i  + + ++Ra+h+at+i
  EFC36795.1 174 GKMYVLAGNAQRTGTFEKELLEFDLEKGNIKpyqTIclGKPFTPRAYHSATYI 226
                 689*******877***************8885524499999**********97 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00074
     Kelch_3   2 drlyifGGlgddg..qdrlndvyvydldtntWaei..as.lppaRag 43 
                 d + ++GG+  +g    ++n+++++ ++t+tW++i   +   p+ +g
  EFC36795.1 230 DVMCVYGGKMKPGlqSGVSNELFLFHFQTHTWENIelRDfIFPPLSG 276
                 6789999999877767788**************88664424555555 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.066
     Kelch_3   4 lyifGGlgd....dgqdrlndvyvydldtnt 30 
                 ++i+GG         +d +++++vy+l+ n+
  EFC36795.1 287 IGIIGGVSKpyseEKEDLNSNLFVYNLEYNS 317
                 5566665555544558899*******97655 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0038        11       6      24 ..     100     121 ..      97     138 .. 0.66
   2 !    5.7   0.0    0.0064        19       2      43 ..     164     206 ..     163     209 .. 0.87
   3 !   15.9   0.0   3.8e-06     0.011       1      44 [.     217     265 ..     217     274 .. 0.87
   4 ?    3.2   0.0     0.041   1.2e+02       5      41 ..     277     319 ..     272     326 .. 0.81
   5 ?   -2.3   0.0       2.2   6.4e+03       6      22 ..     336     352 ..     332     361 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0038
     Kelch_6   6 slvsvg...gkiYifGGytdss 24 
                 ++v+++   + +Y++GG ++  
  EFC36795.1 100 QSVCIDernNNVYVYGGFSGNR 121
                 45555534468*******9843 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0064
     Kelch_6   2 raghslvsvggkiYifGGytds.spylnkvwvydpetksWeql 43 
                 r gh++v+  gk Y++ G+ +  +++ + ++ +d+e +++++ 
  EFC36795.1 164 REGHTAVIRKGKMYVLAGNAQRtGTFEKELLEFDLEKGNIKPY 206
                 669*****************99999999999999998887765 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 3.8e-06
     Kelch_6   1 praghslvsvgg.ki.YifGGytds...spylnkvwvydpetksWeqlp 44 
                 pra+hs++ +    + +++GG   +   s  +n +++++++t++We ++
  EFC36795.1 217 PRAYHSATYIEKrDVmCVYGGKMKPglqSGVSNELFLFHFQTHTWENIE 265
                 6999999999984563777***999*********************875 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.041
     Kelch_6   5 hslvsvgg.kiYifGGytds.....spylnkvwvydpetksWe 41 
                 h ++ +++  i i+GG + +     +   + ++vy++e +s++
  EFC36795.1 277 HYIFKINNdNIGIIGGVSKPyseekEDLNSNLFVYNLEYNSFS 319
                 5566666548********9999999999999999999866665 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 2.2
     Kelch_6   6 slvsvggkiYifGGytd 22 
                 +++s+ +++ ++G  + 
  EFC36795.1 336 AAFSASNQLLAIGAGNT 352
                 56788999999998886 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   1.7e-06    0.0049       1      41 [.      93     134 ..      93     135 .. 0.79
   2 !    5.1   0.0    0.0077        23       5      39 ..     164     198 ..     162     201 .. 0.79
   3 ?    1.3   0.0      0.12   3.6e+02       3      23 ..     216     238 ..     214     257 .. 0.77
   4 ?    3.7   0.0     0.021        61      15      39 ..     285     313 ..     272     315 .. 0.75
   5 ?   -0.1   0.0      0.32   9.6e+02       4      28 ..     330     357 ..     329     360 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.7e-06
     Kelch_5   1 iPppRaghcavtv..sekiYvyGGkvgrdgsvsddvyvLdlps 41 
                 +Pp+R   +++++  ++++YvyGG++g + s+++ + ++++++
  EFC36795.1  93 YPPGRIFQSVCIDerNNNVYVYGGFSG-NRSPCSLITRFSIEG 134
                 5888888899999555**********8.888887776666665 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0077
     Kelch_5   5 RaghcavtvsekiYvyGGkvgrdgsvsddvyvLdl 39 
                 R gh av+ ++k+Yv  G  +r+g +  +++ +dl
  EFC36795.1 164 REGHTAVIRKGKMYVLAGNAQRTGTFEKELLEFDL 198
                 789*************9999866655566666665 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.12
     Kelch_5   3 ppRaghcavtvs..ekiYvyGGk 23 
                 +pRa+h+a + +  + + vyGGk
  EFC36795.1 216 TPRAYHSATYIEkrDVMCVYGGK 238
                 58999999988655768888887 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.021
     Kelch_5  15 ekiYvyGGkv...g.rdgsvsddvyvLdl 39 
                 ++i ++GG++   + + ++++++++v++l
  EFC36795.1 285 DNIGIIGGVSkpySeEKEDLNSNLFVYNL 313
                 777799****774499***********98 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 0.32
     Kelch_5   4 pRaghcavt.vsekiYvyGGkvg..rdg 28 
                 +R++  a++ +s++++ +G  ++  r+g
  EFC36795.1 330 GRYSMPAAFsASNQLLAIGAGNTsyREG 357
                 68999999856999*****999766655 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.1    0.0007       2.1      11      32 ..     108     126 ..      97     129 .. 0.82
   2 ?    1.8   0.0     0.091   2.7e+02       4      39 ..     166     200 ..     163     205 .. 0.83
   3 !   10.7   0.0   0.00014      0.42       1      44 [.     217     263 ..     217     266 .. 0.95
   4 ?   -2.0   0.0       1.4   4.2e+03      14      31 ..     287     307 ..     276     318 .. 0.63

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0007
     Kelch_2  11 ggkiyvvGGahtdnpnlsssdv 32 
                 ++ +yv+GG+    +n+s++++
  EFC36795.1 108 NNNVYVYGGF---SGNRSPCSL 126
                 789*******...999999887 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.091
     Kelch_2   4 ghsssvpggkiyvvGGahtdnpnlsssdvhvldlek 39 
                 gh+++   gk+yv  G  ++ ++ +   +  +dlek
  EFC36795.1 166 GHTAVIRKGKMYVLAGN-AQRTGTFEKELLEFDLEK 200
                 78888889********9.888888888888888887 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00014
     Kelch_2   1 rrgghsssvp..ggkiyvvGGa.htdnpnlsssdvhvldlekhvWee 44 
                 +r+ hs++++  ++ ++v+GG   +++ + +s+ +  + +++h+We+
  EFC36795.1 217 PRAYHSATYIekRDVMCVYGGKmKPGLQSGVSNELFLFHFQTHTWEN 263
                 7999*****************************************97 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.4
     Kelch_2  14 iyvvGGa...htdnpnlsssd 31 
                 i ++GG+   ++ ++ +  s 
  EFC36795.1 287 IGIIGGVskpYSEEKEDLNSN 307
                 558899977744444443333 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.2   0.00025      0.74      11      28 ..     108     125 ..     107     135 .. 0.87
   2 ?    4.0   0.0     0.013        38       3      19 ..     165     181 ..     164     200 .. 0.86
   3 ?    4.2   0.0     0.011        32      19      41 ..     236     263 ..     217     265 .. 0.76
   4 ?   -0.0   0.0      0.22   6.6e+02      16      35 ..     289     314 ..     289     321 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00025
                 TTEEEEEEEBCSSSBEEE CS
     Kelch_1  11 ggkiYviGGsdggnalss 28 
                 ++ +Yv GG++g+++ +s
  EFC36795.1 108 NNNVYVYGGFSGNRSPCS 125
                 789*********887766 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.013
                 BSEEEEEETTEEEEEEE CS
     Kelch_1   3 agagavvvggkiYviGG 19 
                  g++av   gk+Yv+ G
  EFC36795.1 165 EGHTAVIRKGKMYVLAG 181
                 589***********988 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.011
                 EBCS.....SSBEEEEEEEETTTTEEEE CS
     Kelch_1  19 Gsdg.....gnalssvevyDpetntWre 41 
                 G+       +  ++ ++ + + t+tW+ 
  EFC36795.1 236 GGKMkpglqSGVSNELFLFHFQTHTWEN 263
                 333347777778999999********97 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 0.22
                 EEEEBCS......SSBEEEEEEEETT CS
     Kelch_1  16 viGGsdg......gnalssvevyDpe 35 
                 +iGG +           s+++vy++e
  EFC36795.1 289 IIGGVSKpyseekEDLNSNLFVYNLE 314
                 68999999888888889999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2364.20
//
Query:       EFC36796.1  [L=635]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-10   40.5   0.1    4.5e-10   39.4   0.1    1.5  1  PAP2      PAP2 superfamily
  ------ inclusion threshold ------
      0.011   15.5   0.0      0.066   13.0   0.0    2.1  2  VCPO_N    Vanadium chloroperoxidase N-terminal domain


Domain annotation for each model (and alignments):
>> PAP2  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.4   0.1     5e-14   4.5e-10       4     128 ..     497     626 ..     494     632 .. 0.88

  Alignments for each domain:
  == domain 1  score: 39.4 bits;  conditional E-value: 5e-14
        PAP2   4 alllalalaalltsv.lKdlvgrpRPfflaeetkldtqvstletseskeakesfPSgHsafafalalllalllrrkrkkig........lvllalilll 93 
                 ++l++ +++a+++ +  K+ ++  RP ++++e +++++ + l+t    +a++ + SgHs+ ++a+ ++l+ll+++  + +         +++ ++ l  
  EFC36796.1 497 KVLTITMADAAIVCWnHKYKYNAFRPITVITERESNEWSPLLST----PAFPEYSSGHSTLSAAASTVLSLLFGSDEISFEsvseglihTIRKFTKLSE 591
                 55555555555555526*********************988886....678888***********************************9999999*** PP

        PAP2  94 lavlvalsRlylgvHflsDvlaGlliGialaalay 128
                 +a + + sR+y g+Hf  +  aG+  Gia+a  ++
  EFC36796.1 592 AAKEAGKSRIYGGIHFEYANQAGFGSGIAIAQTVF 626
                 *****************************998766 PP

>> VCPO_N  Vanadium chloroperoxidase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   7.3e-06     0.066       6      60 ..     246     294 ..     243     330 .. 0.78
   2 ?   -0.7   0.0      0.12   1.1e+03      88     121 ..     547     583 ..     517     628 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 7.3e-06
      VCPO_N   6 epaeyntnyilyWnsvaldlnrlthsvagPqtgPpisaralgilhlaihdayfai 60 
                 e++ +n++ ++ Wn+v l + r        + + pi++r l+ilh ai+d+    
  EFC36796.1 246 EKDIFNEDIVIKWNNVLLSVIR------DLKVSAPIASRQLAILHSAIDDSLVDC 294
                 6777888888888888776554......5577889***************97654 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.12
      VCPO_N  88 ddarqavagaaitvleklytqpsps...isrnatael 121
                    +  +++aa tvl+ l+ + + s   +s+   + +
  EFC36796.1 547 SSGHSTLSAAASTVLSLLFGSDEISfesVSEGLIHTI 583
                 5556678899999999999665544223555444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (635 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 3538.99
//
Query:       EFC36797.1  [L=1286]
Description: hypothetical protein NAEGRDRAFT_82124 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-17   64.0   2.9    1.4e-09   38.2   0.1    4.2  3  BTB_2           BTB/POZ domain
  ------ inclusion threshold ------
        5.2    6.8   9.4        1.2    9.0   0.8    2.7  2  DUF241          Arabidopsis protein of unknown function


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1     0.018   1.6e+02       1      18 [.      95     112 ..      95     128 .. 0.88
   2 !   20.2   0.1   6.4e-08   0.00057      37      88 ..     200     256 ..     179     260 .. 0.72
   3 !   38.2   0.1   1.5e-13   1.4e-09       1      91 [.     346     437 ..     346     440 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.018
                 EEEEETTEEEEEEHHHHH CS
       BTB_2   1 vklnVgGtrfetskstLs 18 
                 v+l VgG+ f t+ +tL+
  EFC36797.1  95 VVLKVGGKFFYTTMKTLM 112
                 7899************98 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 6.4e-08
                 EETTTTEEEE-S-HHHHHHHHHHHHS.S-B---.....TTS-HHHHHHHHHHHT--T CS
       BTB_2  37 ydeetneyffDRspklFetiLnyyrtggkLhrp.....eevelkslleElefyglee 88 
                   +++   f DR+p++Fe+iL+ +r+ggk++       +  el+++leE +++  e+
  EFC36797.1 200 EANKSAISFPDRNPDYFEYILEHLRQGGKVKSLgieklNADELENILEESRYFATEK 256
                 4555666799******************99875221113445667889999997666 PP

  == domain 3  score: 38.2 bits;  conditional E-value: 1.5e-13
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-B--....-TTS-HHHHHHHHHHHT--TT-B CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtggkLhr....peevelkslleElefygleelll 91 
                 vk++V+G +f +  + L+++ + lL+k       ++  +e++++f+DR+pklF+ i  y+ +ggk ++     ++++  +l++E+efygl++l +
  EFC36797.1 346 VKIDVSGQIFTIPFTSLRKYENFLLSKYILSP--NFGLNENGCVFIDRNPKLFALIHGYIISGGKFNHfpknLSQEKKLQLKQEAEFYGLTTL-V 437
                 89****************9******9999955..8888999**********************99964211146778889**********998.4 PP

>> DUF241  Arabidopsis protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   2.2     0.037   3.3e+02     183     200 ..      46      64 ..       2     156 .. 0.54
   2 ?    9.0   0.8   0.00013       1.2     169     226 ..     270     329 ..     244     330 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.037
      DUF241 183 alesllssskkek.vqsal 200
                 al++l+ ++++e+ ++++ 
  EFC36797.1  46 ALHRLSLQKQTEEmIKKLV 64 
                 4444444433333322222 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00013
      DUF241 169 eeeeeenelekvdaalesllssskkek..vqsalkrleeleecieelEeglekvfRrLIk 226
                 + +++ + ++++++ l++ +++ kk +  ++++++rl+++e++i+e  +++   +R+L+ 
  EFC36797.1 270 KYDSNLSNYAEIEEILNDSVQNLKKVEipLEQIQQRLKSFEDSINESKKSVGEYSRKLVE 329
                 3445788888899999999999888889******************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1809  (0.100898); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.10u 0.32s 00:00:01.42 Elapsed: 00:00:00.56
# Mc/sec: 6886.63
//
Query:       EFC36798.1  [L=684]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (684 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 4218.96
//
Query:       EFC36799.1  [L=652]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.036   14.0   2.7       0.34   10.8   3.1    2.1  2  DUF5089      Domain of unknown function (DUF5089)
       0.44    9.6  10.0       0.63    9.1  10.0    1.1  1  DUF2457      Protein of unknown function (DUF2457)
        1.1    9.6   4.8        1.9    8.8   4.8    1.3  1  PTPRCAP      Protein tyrosine phosphatase receptor type C-ass


Domain annotation for each model (and alignments):
>> DUF5089  Domain of unknown function (DUF5089)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   3.1   5.6e-05      0.34      84     141 ..      37      89 ..      31     108 .. 0.63
   2 ?   -0.5   0.0      0.16   9.8e+02     134     157 ..     443     465 ..     432     466 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 5.6e-05
     DUF5089  84 vdkikkwfkkdkkaeeeveeiknkeeeakeeeedkkeeeefipedkelvpgeektdke 141
                  ++ikkw+k d++  e+ +e+  ++e+++++ +d +++e++++++   v++eek+d+e
  EFC36799.1  37 NSQIKKWIKTDAH--ENTHEFYMEREDSDDDDDD-EDDEDYVEDN--QVDDEEKVDNE 89 
                 579********76..5666666555555333333.2455555433..34566666655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.16
     DUF5089 134 geektdkeLekilnglkslkkeae 157
                 + +ktd+eL    n+l +++++a+
  EFC36799.1 443 S-KKTDSELDWAANCLCEMREKAS 465
                 4.49***************99985 PP

>> DUF2457  Protein of unknown function (DUF2457)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1  10.0   0.00011      0.63      46      91 ..      44      89 ..       7     110 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00011
     DUF2457 46 aeeEaeeeeeeeeddeedeeddddddddedddedddeedededdds 91
                +  +a+e+ +e   + ed++ddddd+dded  ed++ +de++ d++
  EFC36799.1 44 IKTDAHENTHEFYMEREDSDDDDDDEDDEDYVEDNQVDDEEKVDNE 89
                4444555444444444444444444444444444444444442222 PP

>> PTPRCAP  Protein tyrosine phosphatase receptor type C-associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   4.8   0.00031       1.9      28      75 ..      38      87 ..      30      98 .. 0.59

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00031
     PTPRCAP 28 sppgrWlraraedgeed..eeeEdqedeedeeedsedleggeeeaesqee 75
                s   +W +++a +++++   e Ed +d++d e+d+  +e+++ ++e++ +
  EFC36799.1 38 SQIKKWIKTDAHENTHEfyMEREDSDDDDDDEDDEDYVEDNQVDDEEKVD 87
                56779****99555444114566666666666665444444444443332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (652 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1008  (0.0562218); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.79u 0.36s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 3566.65
//
Query:       EFC36800.1  [L=188]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (188 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       376  (0.0209716); expected 358.6 (0.02)
Passed bias filter:                      253  (0.0141112); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 1108.27
//
Query:       EFC36801.1  [L=538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.5e-29  100.7   4.4    2.3e-13   50.1   1.7    3.3  3  Pkinase         Protein kinase domain
    2.7e-14   53.1   3.9    9.4e-08   31.7   0.3    3.8  3  Pkinase_Tyr     Protein tyrosine kinase
     0.0028   16.5   0.2     0.0053   15.6   0.2    1.4  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.012   14.9   0.3        0.1   11.9   0.0    2.3  2  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.1   1.7   5.1e-17   2.3e-13      49     132 ..     129     216 ..      82     228 .. 0.82
   2 !   26.5   0.0   8.4e-10   3.8e-06     137     174 ..     292     329 ..     274     342 .. 0.82
   3 !   22.8   0.0   1.1e-08     5e-05     173     260 ..     366     465 ..     351     469 .. 0.66

  Alignments for each domain:
  == domain 1  score: 50.1 bits;  conditional E-value: 5.1e-17
                 HHHHHHHSCTTB--EEEEEEE....SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEE CS
     Pkinase  49 ikilkklkhpnivrlyevfee....kdelylvleyveggeladllerkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid 132
                  + l  l+h niv+++++f +     ++l +++e++  ++l++l   k+ ++ +   ++  +i+++l+y+H + +iiHrD+Kp+NiL++
  EFC36801.1 129 STTLSDLEHLNIVKYFDSFISqnigGKYLNILQEFCI-TSLQKLFDLKQDIPISYQIQWSLHIAQALKYIHdECKIIHRDVKPDNILLK 216
                 46788999***********99899999*********9.569999998889*********************5566************98 PP

  == domain 2  score: 26.5 bits;  conditional E-value: 8.4e-10
                 EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.TTSCB CS
     Pkinase 137 lKitDFGlakelessskltsfvgtseYlAPEvl.keney 174
                 +K++DF+ ak+++ s+ +++fvg++eY APE++ + n+y
  EFC36801.1 292 IKLADFDYAKKVDLSN-AKTFVGSQEYFAPEIInSLNNY 329
                 9*************98.****************644666 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 1.1e-08
                 CBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHH.HCT......SHH...HHHTTS..............-HHHHHHHHHHT-SSGC CS
     Pkinase 173 eyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilk.ilg......etkeklpeasei..............seeakdllkkllkkdpk 250
                  y++kvD+Ws G++ ++l+   p+++   +  k+++el++  + +k +l+          ++++                   + + +++ ++l+ dp+
  EFC36801.1 366 YYTHKVDIWSFGIVAFQLIK--PIYRL--NIPKFREELQKNPNYVKeLLKdhlnisS--SNFET---QrkpqslpnsnnhlyLQCLAQIIVDCLQLDPT 455
                 57****************64..44442..2223344444422222202223223322..22222...12335578888889889999************ PP

                 CSTTHHHHHT CS
     Pkinase 251 kRltaeellq 260
                  R+ a+++++
  EFC36801.1 456 ARPEAKDIVR 465
                 ******9986 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7   0.3   2.1e-11   9.4e-08      51     138 ..     128     217 ..     113     250 .. 0.82
   2 ?    2.2   0.0     0.021        93     139     181 ..     289     327 ..     286     334 .. 0.82
   3 !   17.0   0.2     6e-07    0.0027     180     258 ..     365     466 ..     358     467 .. 0.71

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 2.1e-11
                  HHHHHHTS-BTTB--EEEEEE....SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE CS
  Pkinase_Tyr  51 eakimkklkhpnivkllgvct....keepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse 138
                  + +++++l+h nivk+    +     ++ l i+ e++   +L+k    k  + + ++  ++++l++A++++y++++ k++Hrd+   N+Ll++
   EFC36801.1 128 NSTTLSDLEHLNIVKYFDSFIsqniGGKYLNILQEFCI-TSLQKLFDLK--QDIPISYQIQWSLHIAQALKYIHDEcKIIHRDVKPDNILLKK 217
                  567899*********99988855544556889999986.5899888776..999*******************97638*************97 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.021
                  TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE CS
  Pkinase_Tyr 139 nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk 181
                  + ++k++Df  a+++    + +++++   + ++ apE++++ +
   EFC36801.1 289 KLIIKLADFDYAKKV----DLSNAKTFVGSQEYFAPEIINSLN 327
                  6799**********9....6777778888999*****998755 PP

  == domain 3  score: 17.0 bits;  conditional E-value: 6e-07
                  SEEEHHHHHHHHHHHHHHHHTTSSGT......................TTTSHHHHHHHHHHTTEE.S-BBTTSBHHHHHHHHHHT-SSGGGS--HHH CS
  Pkinase_Tyr 180 kkftsksDvWsfGvllwEiftlgesp......................ypglkneevleklkegkr.lekpekcpeelyelmkkcweedpeeRptfse 254
                    +t+k D+WsfG++ + +++   +                       + +++++++ ++ k +    ++++   + l++++ +c++ dp+ Rp+ ++
   EFC36801.1 365 YYYTHKVDIWSFGIVAFQLIKPIYRLnipkfreelqknpnyvkellkdHLNISSSNFETQRKPQSLpNSNNHLYLQCLAQIIVDCLQLDPTARPEAKD 462
                  459****************9855443677999999999998777754444444444444443333212233334577889****************** PP

                  HHHH CS
  Pkinase_Tyr 255 lvek 258
                  +v++
   EFC36801.1 463 IVRN 466
                  9986 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.2   1.2e-06    0.0053     318     386 ..     193     323 ..     188     332 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.2e-06
  Pkinase_fungal 318 ghrsLflkagiLHrDiSenNilit..............................................................dskke.... 346
                     +++  + +++i+HrD+  +Nil+                                                               ++k+     
      EFC36801.1 193 ALKYIHDECKIIHRDVKPDNILLKkvisnnlpnlanlnnnnlnnnsnnnsanndggannekqnnlsinttiqvnngnsnqnftninNEKSPaspq 287
                     6778899*****************************************************************99999999888886333333332 PP

  Pkinase_fungal 347 gerkglLiDLDlakelsddssesgarertGTleFmaievl 386
                     ++    L+D+D+ak+++     s+a++ +G  e+ a e++
      EFC36801.1 288 SKLIIKLADFDYAKKVDL----SNAKTFVGSQEYFAPEII 323
                     33334578*********7....444567777777777666 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.3      0.11   4.8e+02      82     125 ..      82     133 ..      64     229 .. 0.59
   2 ?   11.9   0.0   2.3e-05       0.1     214     284 ..     354     417 ..     346     420 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.11
  Kinase-like  82 rlllpfdlvkiqkkkpfiqlkskesiywvvnallllpaasvdl..........e 125
                   l+ p+d+  i   k++     ++ +y   + lll + + +++           
   EFC36801.1  82 ELIEPHDIKGIYALKRIKLDDIDNYDY--GSNLLLKQTIDMNIdkncvnsttlS 133
                  567777777777777777777777777..6777777777777754444443330 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 2.3e-05
  Kinase-like 214 gsrggytrknktkmthkldaWqlGlviyriwclklPltlateeakeewkfklckkipekvkaLlkkfLqls 284
                  +s g  +++ +  +thk+d W  G+v++ +        l  +++ ee      +k p+ vk Llk  L+ s
   EFC36801.1 354 SSNGSNHTNDRYYYTHKVDIWSFGIVAFQLIK--PIYRLNIPKFREE-----LQKNPNYVKELLKDHLNIS 417
                  4555567778999***************9742..2245666777777.....6777888888888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1321  (0.0736795); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.48
# Mc/sec: 3372.42
//
Query:       EFC36802.1  [L=306]
Description: prohibitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-21   76.8   0.8    4.4e-21   75.7   0.8    1.5  1  Band_7    SPFH domain / Band 7 family


Domain annotation for each model (and alignments):
>> Band_7  SPFH domain / Band 7 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.7   0.8   2.4e-25   4.4e-21       2     176 ..      56     232 ..      55     235 .. 0.89

  Alignments for each domain:
  == domain 1  score: 75.7 bits;  conditional E-value: 2.4e-25
      Band_7   2 iieegevgvvvr..fGklsrvlepGlhfilPfgrsvtvvsvrvqtldvsvsltvptkDglpvtidvtviyrvpddapklvaav.eresanldnlirrvl 97 
                 ++e g  ++ ++  +G  +rv++ G+h+ +P +++ +++++r     +s   ++ +kD + v++ ++v ++   d+++l + +   + ++ d+++ +++
  EFC36802.1  56 VVEGGFKAIKFNrfTGVGDRVYGEGYHLLIPGIERPIIYDQRATPKVISS--NTGSKDLQTVNLSIRVLFKP--DVNRLDQIYrSLGMNYSDRVMPSIV 150
                 78899999999999999999**********************87777888..899***************99..5555555554449999********* PP

      Band_7  98 esalrevisemtleellsnreelaeelknelneqlrkyGvevldvritdidpppevaqalaakqaaeaea...qaeiaraea 176
                  ++l++v++++t++ell +r ++ +++++ l +++r +++ + dv it++++ +e+ +a+++kq a++ea   +  +++a++
  EFC36802.1 151 TEVLKSVVAQFTAAELLTKRPDVSARIRDSLVARARDFNIIIDDVAITHLRFGDEYSAAVERKQVAQQEAeraKFIVEKAKE 232
                 **********************************************************************866333444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (306 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       988  (0.0551063); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1945.15
//
Query:       EFC36803.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.1e-20   71.8  23.0    9.3e-20   71.2  23.0    1.3  1  TRAM_LAG1_CLN8  TLC domain


Domain annotation for each model (and alignments):
>> TRAM_LAG1_CLN8  TLC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.2  23.0   5.2e-24   9.3e-20       1     198 []     106     310 ..     106     310 .. 0.83

  Alignments for each domain:
  == domain 1  score: 71.2 bits;  conditional E-value: 5.2e-24
  TRAM_LAG1_CLN8   1 kfdervvslvqyllstvfglivlsssp.elwegy.........perilgathfllkayyllalgYfiydllvlllyekkrk..dfvemliHhiit 83 
                     k+++++vs++++ +++  ++ +l      +++ +         +++  g+   l+++y+++  gY++yd++v++  +       f+ ++iHh+  
      EFC36803.1 106 KWNVKFVSALHAAFVFQGAFRCLLYGGgLFFNSDpiddglvgfQKFSCGYYTDLSRFYMAITFGYMFYDFWVCIRAYGLTLegIFPSLVIHHFNI 200
                     7*******************888888863333335667778888888899999********************9987554455**********99 PP

  TRAM_LAG1_CLN8  84 lvllvlsyvrnlgrvglvvlllhelsdpflnlrkilsylkkkskssklvlfn.gllfllsFfvcRlvllpylillsildvaklslstaplwlpli 177
                     ++ ++l++  ++g+++++ +++ e+s+pfl+l+++l++  k   ++  v+++ gl+++l+F+  R++   y +++ i + ++ +l    +++  i
      EFC36803.1 201 IISFLLALKLGMGHYYSLSFMTNEISQPFLHLSWFLIKS-KV-PQLHPVSIVnGLMLVLTFLGSRFFFNAYIFYHFIEKTFSFQL----TNCLGI 289
                     99*************************************.54.4445666666****************9988887777776332....445555 PP

  TRAM_LAG1_CLN8 178 flilllvLqllnlyWfylivk 198
                         +l+  ++n+ W++l+vk
      EFC36803.1 290 GTWTCLIHVACNWDWCWLMVK 310
                     55555566789********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       558  (0.0311228); expected 358.6 (0.02)
Passed bias filter:                      307  (0.0171231); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.22s 00:00:00.63 Elapsed: 00:00:00.39
# Mc/sec: 2578.38
//
Query:       EFC36804.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-15   55.6  27.5    1.1e-09   38.0  10.2    2.6  2  PHD       PHD-finger
     0.0011   18.7   4.9     0.0011   18.7   4.9    3.6  4  C1_1      Phorbol esters/diacylglycerol binding domain (C1 do
     0.0049   16.4   8.0     0.0049   16.4   8.0    3.4  3  PHD_2     PHD-finger
  ------ inclusion threshold ------
      0.038   14.1  26.9       0.31   11.2   2.6    3.9  3  DUF2318   Predicted membrane protein (DUF2318)
        1.1    7.9   4.7        1.5    7.5   4.7    1.2  1  Ndc1_Nup  Nucleoporin protein Ndc1-Nup


Domain annotation for each model (and alignments):
>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8  11.0   1.8e-08   6.4e-05       2      52 .]      32      83 ..      31      83 .. 0.89
   2 !   38.0  10.2     3e-13   1.1e-09       2      50 ..      83     132 ..      82     134 .. 0.94

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 1.8e-08
                BTTTTS..TTSTTSCEEEETTTSCEEETTTSSSTHSHHSHHSSTBSSTTTHTT CS
         PHD  2 CavCkk..ksdeeeelvqCdgCkrwfHqkClkppleseekpegewlCekCkek 52
                C vC+k  + +++++++ C++C+  +H  C++ +  s +  + +w C  Ck++
  EFC36804.1 32 CYVCHKtnEGTDKQTMLTCKTCGLKVHAGCYENTHFSLKYAD-SWECVDCKKC 83
                9*****9777789*********************99666665.9******986 PP

  == domain 2  score: 38.0 bits;  conditional E-value: 3e-13
                 BTTTTS.TTSTTSCEEEETTTSCEEETTTSSSTHSHHSHHSSTBSSTTTH CS
         PHD   2 CavCkk.ksdeeeelvqCdgCkrwfHqkClkppleseekpegewlCekCk 50 
                 C+vCk+ +  e++e+++C++C++ +Hq C++ + ++ ++ ++ w+Ce+C 
  EFC36804.1  83 CEVCKDaNYREGNEILMCNRCDKGYHQLCCSEKFRTVPEGDKPWFCESCV 132
                 ******99999************************8888888*******6 PP

>> C1_1  Phorbol esters/diacylglycerol binding domain (C1 domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   4.9   3.2e-07    0.0011      12      47 ..      30      66 ..      22      72 .. 0.89
   2 ?   -0.0   0.3      0.23   8.4e+02      24      35 ..      70      81 ..      64      82 .. 0.74
   3 ?    3.9  12.3     0.014        50      12      44 ..      81     113 ..      71     118 .. 0.91
   4 ?    0.7   0.2      0.13   4.8e+02      10      23 ..     124     137 ..     117     145 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 3.2e-07
                -B-TTT-SB--S.SSS-EEEETTT--EE-CCCCTTS- CS
        C1_1 12 tfCkhCgeflwg.kekqglkCswCkllvHkkChekvp 47
                + C  C +  +g    ++l+C++C+l+vH  C+e+ +
  EFC36804.1 30 NGCYVCHKTNEGtDKQTMLTCKTCGLKVHAGCYENTH 66
                56**********99999****************9876 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.23
                SSS-EEEETTT- CS
        C1_1 24 kekqglkCswCk 35
                k    + C +Ck
  EFC36804.1 70 KYADSWECVDCK 81
                566789999997 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.014
                 -B-TTT-SB--SSSS-EEEETTT--EE-CCCCT CS
        C1_1  12 tfCkhCgeflwgkekqglkCswCkllvHkkChe 44 
                 ++C+ C++  ++++  +l C+ C   +H+ C++
  EFC36804.1  81 KKCEVCKDANYREGNEILMCNRCDKGYHQLCCS 113
                 689999999999******************986 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.13
                 S--B-TTT-SB--S CS
        C1_1  10 qptfCkhCgeflwg 23 
                 +p fC+ C + l++
  EFC36804.1 124 KPWFCESCVDYLKE 137
                 67899999998844 PP

>> PHD_2  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.3         1   3.6e+03      18      27 ..      32      41 ..      30      43 .. 0.76
   2 !   16.4   8.0   1.4e-06    0.0049       4      35 ..      47      80 ..      44      84 .. 0.79
   3 !   10.4   4.5   9.9e-05      0.36       2      35 ..      95     131 ..      94     132 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1
       PHD_2 18 CYGvskesdg 27
                CY + k ++g
  EFC36804.1 32 CYVCHKTNEG 41
                9988888876 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 1.4e-06
       PHD_2  4 llsCdkCsvaVHasCYGvsk..esdgeeWlCrrC 35
                +l+C+ C + VHa CY  +    + +++W C  C
  EFC36804.1 47 MLTCKTCGLKVHAGCYENTHfsLKYADSWECVDC 80
                89**************987511344556*99999 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 9.9e-05
       PHD_2   2 npllsCdkCsvaVHasCY..Gvskesdgee.WlCrrC 35 
                 n +l C++C    H+ C   ++++ ++g++ W C+ C
  EFC36804.1  95 NEILMCNRCDKGYHQLCCseKFRTVPEGDKpWFCESC 131
                 89***************83346666777668****** PP

>> DUF2318  Predicted membrane protein (DUF2318)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   2.6   8.7e-05      0.31      23      62 ..      18      58 ..       3      66 .. 0.80
   2 ?    9.6   8.8   0.00026      0.93      27      60 ..      73     106 ..      56     125 .. 0.83
   3 ?    4.1   0.4     0.014        50      56      98 ..     280     325 ..     223     327 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.7e-05
     DUF2318 23 vkksdgklrvaldaCevC.ekkgYvqegeelvCknCgvrfa 62
                 k++d+++++  + C vC + ++ + ++  l+Ck+Cg +++
  EFC36804.1 18 NKSTDQTISTPTNGCYVChKTNEGTDKQTMLTCKTCGLKVH 58
                57889999**********6556667888999******9887 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00026
     DUF2318  27 dgklrvaldaCevCekkgYvqegeelvCknCgvr 60 
                 d+   v    CevC+++ Y + +e l+C++C++ 
  EFC36804.1  73 DSWECVDCKKCEVCKDANYREGNEILMCNRCDKG 106
                 5545566789*********************986 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.014
     DUF2318  56 nCgvrfa..ldsige.kkGGCnpipleytvkgdkiviskaeleaga 98 
                  C v f+   +++++ ++  C ++ +++ vk+++ +i++  l+++ 
  EFC36804.1 280 LCTVIFNrlSNKMKDlIEDKCVNAEIKKMVKENTFIIDRVALKEKD 325
                 56655553345555558999*******************9999875 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   4.7    0.0004       1.5     336     461 ..     128     232 ..     125     316 .. 0.48

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0004
    Ndc1_Nup 336 lkeClklikeltqrinergq.papkaaps.......kapknkasapvkelprlsksplkkkddeifgnsltaeaspkssssskegvekalsslakspgq 426
                 ++ C++ +ke +q+ +++ + p  ++++s       k+ k+++ + +++               i +      ++p+s+ ++++++++++         
  EFC36804.1 128 CESCVDYLKEKKQKKKRKVEkP-VTKSESaeslfklKPGKHQKVEDKQAP--------------IAT------TTPSSN-ETTSTIKSSTP-------- 196
                 6777777777777777666622.222221233444322222222222222..............222......233222.22222222222........ PP

    Ndc1_Nup 427 spsptarlsprarkllekaksrlls...keqkealses 461
                   +p+++ s ++ +  +++k+ +l+   +++++ ++ +
  EFC36804.1 197 --PPPPSSSVSSTNGSTNDKEPVLEsngHKKEQHAQTE 232
                 ..222222233333333334444442221112222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1916  (0.106866); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.43
# Mc/sec: 2601.98
//
Query:       EFC36805.1  [L=295]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-06   27.8   0.7    4.1e-06   26.7   0.7    1.6  1  SNARE           SNARE domain
    1.9e-05   24.8   1.4    4.7e-05   23.6   1.4    1.7  1  V-SNARE_C       Snare region anchored in the vesicle membrane
     0.0057   16.5   0.4     0.0057   16.5   0.4    2.6  3  Sec20           Sec20
     0.0063   16.3   2.6     0.0063   16.3   2.6    2.4  3  Synaptobrevin   Synaptobrevin
  ------ inclusion threshold ------
      0.085   13.5   9.3        1.3    9.7   0.0    3.0  2  OAD_gamma       Oxaloacetate decarboxylase, gamma chain
       0.12   13.4  10.8       0.58   11.2   0.0    2.9  2  DUF4834         Domain of unknown function (DUF4834)
       0.15   12.0   0.5       0.94    9.4   0.3    2.2  2  T2SSF           Type II secretion system (T2SS), protein F
       0.15   12.2   0.0       0.45   10.7   0.0    1.8  1  HemY_N          HemY protein N-terminus
       0.16   12.2   0.0       0.16   12.2   0.0    2.4  2  DUF2371         Uncharacterised conserved protein (DUF2371)
       0.83   10.1   0.0       0.83   10.1   0.0    3.1  1  G0-G1_switch_2  G0/G1 switch protein 2
       0.98    9.2   9.8       0.15   11.8   1.9    2.4  2  MCPsignal       Methyl-accepting chemotaxis protein (MCP) sig
        1.8    7.7   0.0        1.8    7.7   0.0    2.1  2  Zip             ZIP Zinc transporter
        3.3    7.6  14.1        0.6    9.9   1.1    3.8  4  Vpu             Vpu protein


Domain annotation for each model (and alignments):
>> SNARE  SNARE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.7     3e-09   4.1e-06       1      53 []     193     245 ..     193     245 .. 0.98

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 3e-09
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTXXXXXXXXXXXXXXXXXXXX CS
       SNARE   1 emvDrIdtnVenaqsnveraqkeLkkavkyqksnRklkciillilviillvvl 53 
                 e++ rId ++++  sn+ r+ +eLk ++++       +++ill+++ +l +++
  EFC36805.1 193 EQLERIDKEMDELGSNITRGSNELKSFMRRLATDKLIMVLILLVVLAVLGIII 245
                 799**********************************************9996 PP

>> V-SNARE_C  Snare region anchored in the vesicle membrane C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   1.4   3.4e-08   4.7e-05      15      65 ..     172     222 ..     160     223 .. 0.91

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 3.4e-08
   V-SNARE_C  15 rivdetisiGaailedLhsQretLkrarsklhnvanrlgksnsiLrsikrR 65 
                   +det +i+a+ +e L++Qre+L+r+ + + ++++++ + +  L+s +rR
  EFC36805.1 172 DKADETKAIAAESMEMLKRQREQLERIDKEMDELGSNITRGSNELKSFMRR 222
                 579***********************************9999999998888 PP

>> Sec20  Sec20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1       1.3   1.8e+03      30      46 ..      76      92 ..      44     135 .. 0.58
   2 ?   -0.8   0.1         1   1.4e+03      34      62 ..     142     170 ..     107     181 .. 0.62
   3 !   16.5   0.4   4.2e-06    0.0057      24      91 ..     181     247 ..     162     248 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.3
       Sec20 30 eldastkslekleeeyk 46
                +l++   ++ kl ++++
  EFC36805.1 76 KLSQHKSEIAKLLQNFQ 92
                33333334444433333 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1
       Sec20  34 stkslekleeeykqvedvlsrskklvkkl 62 
                 +tk+ + ++e +k++ ++   s ++vk l
  EFC36805.1 142 KTKNEQIADELFKEIYETQGDSLDIVKRL 170
                 44444445555555555555555555543 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 4.2e-06
       Sec20  24 SeenleeldastkslekleeeykqvedvlsrskklvkklerrdktdkllvflalglflacvvyvvkkR 91 
                  +e +e l+ + ++le+++ e  ++ + + r+ + +k++ rr  tdkl+++l l   la+   +++ R
  EFC36805.1 181 AAESMEMLKRQREQLERIDKEMDELGSNITRGSNELKSFMRRLATDKLIMVLILLVVLAVLGIIIW-R 247
                 578999******************************************999988555555444444.4 PP

>> Synaptobrevin  Synaptobrevin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.6       1.2   1.7e+03      19      48 ..      87     116 ..      75     124 .. 0.56
   2 ?   -0.7   0.2      0.89   1.2e+03       2      20 ..     116     134 ..     115     150 .. 0.85
   3 !   16.3   2.6   4.6e-06    0.0063       3      86 ..     165     246 ..     163     250 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.2
                    HCCHHHHCHCCCCCHHHHCCCCHHHHHHHH CS
  Synaptobrevin  19 mkeNidkvlergekldeLvdktenLqssaq 48 
                    + +N++ + e+ +k ++L   te+ +++++
     EFC36805.1  87 LLQNFQTAKEKSNKDELLGATTEKKKETSK 116
                    345555555555555555555555555444 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.89
                    XXHHHHHHHHHHCCCCHHC CS
  Synaptobrevin   2 ndklakikaevdevkdimk 20 
                    ++k++k+k++ dev++++ 
     EFC36805.1 116 KKKTNKTKDDDDEVVEVVA 134
                    7899999999999999876 PP

  == domain 3  score: 16.3 bits;  conditional E-value: 4.6e-06
                    XHHHHHHHHHHCCCCHHCCHHHHCHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHTX.XXXXXXXXXXXXXXXXXXXX CS
  Synaptobrevin   3 dklakikaevdevkdimkeNidkvlergekldeLvdktenLqssaqqFkkqarklkrkmwwknm.kliiililvvlililiiiiv 86 
                    d ++++ ++ de+k i  e ++ +   +e+l+ ++++ ++L s   +  + +++lk  m      kli++lil+v++ +l iii+
     EFC36805.1 165 DIVKRLIDKADETKAIAAESMEMLKRQREQLERIDKEMDELGS---NITRGSNELKSFMRRLATdKLIMVLILLVVLAVLGIIIW 246
                    667888999**************************99777765...567888888877765444566666666555555555544 PP

>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   8.9      0.52   7.2e+02      43      70 ..     106     134 ..      82     184 .. 0.76
   2 ?    9.7   0.0   0.00091       1.3       8      57 ..     231     278 ..     228     291 .. 0.66

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.52
   OAD_gamma  43 akaaaaaaaaaaaaa.eldddeelvAvIa 70 
                 a++++++++++++++   ddd+e+v v a
  EFC36805.1 106 ATTEKKKETSKKKTNkTKDDDDEVVEVVA 134
                 33333333333333367799999999876 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00091
   OAD_gamma   8 llGmgvVFvvLilLslvi.slfskiikkkakkkkkkakaaaaaaaaaaaaa 57 
                 +l   + +vvL++L ++i +++ + ++k+ +k++++++ ++ +++++++++
  EFC36805.1 231 VL---ILLVVLAVLGIIIwRIVDYCVNKFMPKQNNNNSGNTTPQKSTTKTT 278
                 44...4455566665555145889999999988888888888887777664 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   9.6      0.89   1.2e+03      28      94 ..      90     131 ..      49     204 .. 0.61
   2 ?   11.2   0.0   0.00042      0.58       7      74 ..     229     287 ..     225     294 .. 0.37

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.89
     DUF4834  28 tvfglgsrkkssksaqkqfgnstnsnqqksq.srsetkeegeiieeersekeakrk.kiFekdeGEYVd 94 
                 +                          +++  ++s+++e   +++e+++e+++k+  k  ++d++E V+
  EFC36805.1  90 N--------------------------FQTAkEKSNKDELLGATTEKKKETSKKKTnK-TKDDDDEVVE 131
                 1..........................1111122222222222222222222222223.2455555554 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00042
     DUF4834   7 ilifiiailviglsilsvilrtvfglgsrkkssksaqkqfgnstnsnqqksqsrsetkeegeiieeer 74 
                 i   +++il+++l++l+ i+ ++     +    k + kq +n++++n +  q+++++++e +++e+ +
  EFC36805.1 229 I---MVLILLVVLAVLGIIIWRIVDYCVN----KFMPKQ-NNNNSGN-TTPQKSTTKTTEMDMYEQYN 287
                 3...3333333444444444444222211....112222.2222222.22223344444445555444 PP

>> T2SSF  Type II secretion system (T2SS), protein F
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.53   7.3e+02      28      75 ..      50      99 ..      39     120 .. 0.71
   2 ?    9.4   0.3   0.00068      0.94      60     124 ..     180     245 ..     128     246 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.53
                SHHHHHHHHHHHHHHHTTSSHHHHHC....T-TT.TS-HHHHHHHHHHHHHT CS
       T2SSF 28 ngplaeelkriarrlraGgslseale....rtpssefpelvvqlirageegg 75
                ++ l+++ k + r +++ g ++++++    +++ se+++l++++ +a e++ 
  EFC36805.1 50 FKSLQKIYKGMFRSVQMEG-VDASWKkklsQHK-SEIAKLLQNFQTAKEKSN 99
                5667777777777777766.5555555563554.599999999998888775 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00068
                 S.-HHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHHHHHHHHHHHTTXXXXXXXXXXXXXXXXXXX CS
       T2SSF  60 f.pelvvqlirageeggnLaevLerlaeyleeerelrrkllaallepllllvvallvllillaill 124
                 + +e + +l r+ e+  ++++ ++ l +++ +  +  +  + +l+  +l++v++llv+l++l+i++
  EFC36805.1 180 IaAESMEMLKRQREQLERIDKEMDELGSNITRGSNELKSFMRRLATDKLIMVLILLVVLAVLGIII 245
                 4477788889999999***********************************************986 PP

>> HemY_N  HemY protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00033      0.45      16      42 ..     228     254 ..     223     279 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00033
      HemY_N  16 lvvavlllvllfvllylllrllrlllr 42 
                 l+++++llv+l+vl ++++r++   ++
  EFC36805.1 228 LIMVLILLVVLAVLGIIIWRIVDYCVN 254
                 89*******************987765 PP

>> DUF2371  Uncharacterised conserved protein (DUF2371)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   2.3       3.3   4.6e+03       9      22 ..     110     123 ..      93     138 .. 0.54
   2 ?   12.2   0.0   0.00012      0.16      42     107 ..     230     295 .]     184     295 .] 0.72

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.3
     DUF2371   9 kraeakrkkkakkk 22 
                 k+ e+++kk++k+k
  EFC36805.1 110 KKKETSKKKTNKTK 123
                 22222223333333 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00012
     DUF2371  42 lvlllGllvllvGiama.vlgywpkkaklaseekssssstaessseklgllarfleqylysdklkvl 107
                 +vl+l +++ ++Gi +  ++ y  +k  + ++++++s +t+ ++s++ ++ +++ eqy  sd ++++
  EFC36805.1 230 MVLILLVVLAVLGIIIWrIVDYCVNK-FMPKQNNNNSGNTTPQKSTTKTTEMDMYEQYNPSDYVRLF 295
                 33334444445676654155555555.5666677777777777788888999*********999886 PP

>> G0-G1_switch_2  G0/G1 switch protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0    0.0006      0.83      12      70 ..     217     276 ..     214     290 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.0006
  G0-G1_switch_2  12 kemlsqkpsrklvklYvlGsvLallGvvi.glvetvcspFssesrlreeeeavaklqaar 70 
                     k  +++  + kl+ + +l  vLa+lG++i  +v+  ++ F  +++ ++  +++ ++++++
      EFC36805.1 217 KSFMRRLATDKLIMVLILLVVLAVLGIIIwRIVDYCVNKFMPKQNNNNSGNTTPQKSTTK 276
                     67788889999***************9874799999999*99887766655444433322 PP

>> MCPsignal  Methyl-accepting chemotaxis protein (MCP) signalling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   3.3      0.45   6.2e+02      86     139 ..      79     135 ..      71     148 .. 0.66
   2 ?   11.8   1.9   0.00011      0.15      85     157 ..     143     215 ..     132     226 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.45
                 HHHHHHHHHH.................HHHHHHHHHHHHHHHHHCCHHHHHHHHHHH CS
   MCPsignal  86 qaakeiealiieiqkeindsve..sl.eetrqrveegselveetgealkeiveavae 139
                 q   ei++l+++ q   ++s +   l   t+++ e++ +++++t+++  e+ve va+
  EFC36805.1  79 QHKSEIAKLLQNFQTAKEKSNKdeLLgATTEKKKETSKKKTNKTKDDDDEVVEVVAS 135
                 555678888877776655554311441445566666777888888888888887764 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 0.00011
                 HHHHHHHHHHH..............HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   MCPsignal  85 aqaakeiealiieiqkeindsvesleetrqrveegselveetgealkeiveavaevadlvqeiaaaseeqsas 157
                  +  +  ++l +ei +   ds+++++    +++e+  +++e+ e lk+  e+ ++++++++e+ +  +  s+ 
  EFC36805.1 143 TKNEQIADELFKEIYETQGDSLDIVKRLIDKADETKAIAAESMEMLKRQREQLERIDKEMDELGSNITRGSNE 215
                 333333457888999999*******************************************998776665554 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   8.7       5.3   7.3e+03     109     143 ..      97     130 ..      59     185 .. 0.51
   2 ?    7.7   0.0    0.0013       1.8      75     119 ..     222     278 ..     180     291 .. 0.66

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 5.3
         Zip 109 ktpkkasssssesaakksvsndkveeseekedhva 143
                 k++k++    +++++k+  s++k+++++++ d+v+
  EFC36805.1  97 KSNKDELLGATTEKKKE-TSKKKTNKTKDDDDEVV 130
                 22222211111222111.12222222222212211 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0013
         Zip  75 h..........plagllvllGflllllveklltmivek..ksshkektpkkasssss 119
                            +l  +l++lG+++  +v+ +++ +++k  +++ +++tp+k++++++
  EFC36805.1 222 RlatdklimvlILLVVLAVLGIIIWRIVDYCVNKFMPKqnNNNSGNTTPQKSTTKTT 278
                 055555555567778999********************6433333333333333332 PP

>> Vpu  Vpu protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.2     0.032        44      29      55 ..      72     100 ..      68     114 .. 0.87
   2 ?    1.1   0.2      0.24   3.3e+02      32      53 ..     142     163 ..     137     176 .. 0.85
   3 ?   -2.2   0.1       2.6   3.6e+03      31      40 ..     189     203 ..     183     213 .. 0.54
   4 ?    9.9   1.1   0.00044       0.6       5      26 ..     228     249 ..     224     263 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.032
         Vpu  29 eykkikkq..keierlikrireraedSgn 55 
                  +kk+  q   ei +l++  +  +e+S+ 
  EFC36805.1  72 SWKKKLSQhkSEIAKLLQNFQTAKEKSNK 100
                 69999999889***************964 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.24
         Vpu  32 kikkqkeierlikrireraedS 53 
                 k k+++  ++l+k i e++ dS
  EFC36805.1 142 KTKNEQIADELFKEIYETQGDS 163
                 6677788899999999999998 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 2.6
         Vpu  31 kkikkq.....keie 40 
                 k++++q     ke++
  EFC36805.1 189 KRQREQleridKEMD 203
                 444455522334444 PP

  == domain 4  score: 9.9 bits;  conditional E-value: 0.00044
         Vpu   5 eliglialivaliiaivvWtiv 26 
                  ++ li+l+v+ ++ i++W+iv
  EFC36805.1 228 LIMVLILLVVLAVLGIIIWRIV 249
                 57899***************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3823  (0.21323); expected 358.6 (0.02)
Passed bias filter:                     1027  (0.0572815); expected 358.6 (0.02)
Passed Vit filter:                       132  (0.00736237); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.86u 0.34s 00:00:01.20 Elapsed: 00:00:00.52
# Mc/sec: 1705.78
//
Query:       EFC36806.1  [L=1009]
Description: hypothetical protein NAEGRDRAFT_82128 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    8.3e-07   29.0   1.7    8.3e-07   29.0   1.7    3.8  4  Vps51       Vps51/Vps67
  ------ inclusion threshold ------
       0.17   12.1   0.9        3.6    7.8   0.1    3.1  2  Stork_head  Winged helix Storkhead-box1 domain
       0.65   10.4   8.6       0.59   10.5   0.2    3.8  4  DUF3510     Domain of unknown function (DUF3510)


Domain annotation for each model (and alignments):
>> Vps51  Vps51/Vps67
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.0   1.7   1.4e-10   8.3e-07      13      67 ..      35      89 ..      28     112 .. 0.84
   2 ?   -0.8   0.1      0.27   1.6e+03      48      66 ..     367     385 ..     366     399 .. 0.77
   3 ?   -3.2   0.1       1.5     9e+03      37      62 ..     547     572 ..     543     572 .. 0.82
   4 ?   -1.7   0.1      0.52   3.1e+03      29      43 ..     634     648 ..     628     649 .. 0.56

  Alignments for each domain:
  == domain 1  score: 29.0 bits;  conditional E-value: 1.4e-10
       Vps51 13 rellakstlkellkveasllseiraldselkalVydnYskLisasdtIrkmksem 67
                ++l +++t+k+++ ++++   ei+ ++++l++lV+++Y++ i+a+d   ++++ +
  EFC36806.1 35 NDLFRNQTVKQIKVIKEKSDEEITIKQNQLRNLVGERYRDIIEAADCMDSIQQLC 89
                56667****************************************9888887766 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.27
       Vps51  48 dnYskLisasdtIrkmkse 66 
                 dn ++Li++ +++++m+ +
  EFC36806.1 367 DNIHDLIEIKKKVKDMSFS 385
                 577899*******999855 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 1.5
       Vps51  37 aldselkalVydnYskLisasdtIrk 62 
                 +  +el +l+++ Y  + + + +I+k
  EFC36806.1 547 EEHAELEELIMTQYFNFYNSATEIVK 572
                 56789999999999999999999875 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.52
       Vps51  29 asllseiraldselk 43 
                 ++l+++i++l++++k
  EFC36806.1 634 RKLRAQITNLKQKKK 648
                 345555555555554 PP

>> Stork_head  Winged helix Storkhead-box1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.1     0.087   5.2e+02      18      47 ..      47      76 ..      45      88 .. 0.90
   2 ?    7.8   0.1   0.00061       3.6       4      36 ..     524     556 ..     522     576 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.087
  Stork_head 18 qvisdlnsaeqsatletlveaLkkaypeiq 47
                +vi + + +e ++++++l++ + ++y++i+
  EFC36806.1 47 KVIKEKSDEEITIKQNQLRNLVGERYRDII 76
                689999999*******************97 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00061
  Stork_head   4 vsQsqfipLeEvlcqvisdlnsaeqsatletlv 36 
                 v  sq +pL   ++ +i dl ++e++a le+l+
  EFC36806.1 524 VFESQIVPLCKEIFLLIQDLQNKEEHAELEELI 556
                 67899***********************99875 PP

>> DUF3510  Domain of unknown function (DUF3510)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.65   3.9e+03      56      68 ..     341     353 ..     307     396 .. 0.56
   2 ?    1.9   0.7     0.045   2.7e+02      36     103 ..     571     651 ..     511     670 .. 0.70
   3 ?    1.8   0.3     0.048   2.9e+02       9      68 ..     628     682 ..     620     706 .. 0.63
   4 ?   10.5   0.2   9.9e-05      0.59      54     125 ..     741     813 ..     708     814 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.65
     DUF3510  56 eevleewlaevle 68 
                 +e ++ew+++ l+
  EFC36806.1 341 PEKIKEWIKDSLK 353
                 3344444444333 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.045
     DUF3510  36 vseilkplktfkkesekk.lseev..........leewlaevleevtsrYleti..sevlssvkkteesLkrlkkarkgaa 103
                 v++ ++  ++f+k+++++  + ++          +++++++++ e+  ++      + +l+ ++k   ++ +lk+++k+ +
  EFC36806.1 571 VKKFIRDPSQFNKDTNNSfSDMDIklycgriiqsMRKLFTDIFIELNVKFSMFSndESFLTIIRKLRAQITNLKQKKKTDT 651
                 444444444444444444333333555555555567777777777777665433114588999999999999999998766 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.048
     DUF3510   9 eaLkqvssiprlyRrtnkevptepSkyvseilkplktfkkesekklseevleewlaevle 68 
                 ++L  +++++++    +++  t  S+y ++ l+  + f     ++l  e+ +ew+++  +
  EFC36806.1 628 SFLTIIRKLRAQITNLKQKKKTDTSPYLTKYLEIDQIF-----ESLYLEAFNEWIEQQTD 682
                 56777788888888888888888888888888777777.....23333443444433333 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 9.9e-05
     DUF3510  54 lseevleewlaevleevtsrYletisevlssvkkteesLkrlkkarkgaaasanggeeasDddkir....lQlalD 125
                 ++++v+e++ +++ ++v+ +Y e i+ ++++ kk e+s +  k  +++a +s  ++++ s ++ i+    lQl++D
  EFC36806.1 741 VDNNVIEKLSNKICTRVFGDYNEWINSLIEKSKKQEKS-NESKVEETSAEES--TESQLSLEEFICedgfLQLLFD 813
                 78899*******************************99.5555555555544..3444555555553444566666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1009 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1862  (0.103854); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.93u 0.32s 00:00:01.25 Elapsed: 00:00:00.54
# Mc/sec: 5659.40
//
Query:       EFC36807.1  [L=504]
Description: phosphoesterase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-75  254.2   7.4    2.5e-75  253.9   7.4    1.1  1  Phosphoesterase  Phosphoesterase family


Domain annotation for each model (and alignments):
>> Phosphoesterase  Phosphoesterase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  253.9   7.4   1.4e-79   2.5e-75       1     356 []      48     443 ..      48     443 .. 0.85

  Alignments for each domain:
  == domain 1  score: 253.9 bits;  conditional E-value: 1.4e-79
  Phosphoesterase   1 ikhvViivqENrsfdhlfGtlkgvrgiddasp..laqqdG........vkkqa.lnkaevsapfsldtakglsaqvvvedpehsfqaiqeqwng 83 
                      ++++++i+ EN s+d lfGt+++ +gi +as    +q d         ++ qa l ++  + pf l +++gl+a+  + d  h f+  q q+ng
       EFC36807.1  48 VNNIIVIMLENWSYDGLFGTYSKGNGIAKASSeaKTQLDDndqaystlPQVQAgLPQNISNGPFDLAQYFGLNAK--TMDVTHAFYTHQYQMNG 139
                      578***********************988888542233325778999988999555555599********98888..9**************** PP

  Phosphoesterase  84 grndkfvaaaes.elvmgyfkr.edipvlwelaqeftlcDryFssvlggtepNrlflisgts............dpsGt............... 148
                      g+++k+v++++   lvm+y++   +  ++ +laq++tl+D++F++++gg+ +N+++li+               + sGt               
       EFC36807.1 140 GKMNKYVPYSAAkGLVMSYYDLvGQGHYMAQLAQNYTLFDYWFQGAFGGSMLNHQWLITPGCpyfpnppssmvnSISGTtgkiiypekaitpdn 233
                      ***********988******9625778899****************************977769998888888844444667999999999999 PP

  Phosphoesterase 149 ..........eggpsladpkktvlkgftqktigerLsekgvswaiYqeal........dnlakskvapfnyyvrklkklearrkalkqlglaak 224
                                +  p +  p  +++++++ +tig+ L+++g+sw++Y++          d  ++ + +pf  ++++  ++e  r++lk+      
       EFC36807.1 234 yvvntaysvnKPYPVTMPPLANLVPSQNTTTIGDLLTSAGISWKWYSGGYndamngtqDSSWQAHHQPFVFFKNYEVGTE-GRNHLKDE----- 321
                      99998888877778878789******************************644433333333333336666666666666.45555444..... PP

  Phosphoesterase 225 qlekfkkdvkngkLPqvsfikpngandeHpg.adva.agdklikevlealtsspqwaktllivtyDEngGfyDhVappvapvsdpdglkGdpyg 316
                         ++ +d+kn++LP+vsf+kp g++++Hpg ++v  + ++ +k+v+ea+++s++w+++++++t+DE gG +DhVapp          k d++g
       EFC36807.1 322 --TDLFNDLKNNQLPSVSFYKPLGKDNMHPGySTVGgSSEEKLKQVIEAVQASKYWNNSMIFITFDEYGGRWDHVAPP----------KVDKWG 403
                      ..4699*************************77764256899************************************..........6789** PP

  Phosphoesterase 317 lgvrvPllviSpyakkgtvdhelfdhtSvlrfiekrfglp 356
                      +g+r+P++ +Sp +kk  v++   d+tS+++fi++rfglp
       EFC36807.1 404 PGSRIPTIAVSPLVKKANVNSVYHDTTSIMKFIQDRFGLP 443
                      **************************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (504 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       666  (0.0371465); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 3029.15
//
Query:       EFC36808.1  [L=436]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.7e-05   24.6   0.0    4.2e-05   23.3   0.0    1.7  1  F-box       F-box domain
     0.0099   16.3   2.1         47    4.6   0.6    4.7  4  LRR_4       Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
      0.062   13.2   0.0       0.15   12.0   0.0    1.6  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.0     7e-09   4.2e-05       2      40 ..       5      43 ..       4      47 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 7e-09
                HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTH CS
       F-box  2 tlsrLPsevlrhILerLplsdllalrrVSkgwrilidsd 40
                t+s+LP + l  +L++Lp  +ll +++VSk  ++++++ 
  EFC36808.1  5 TFSDLPQDELSVVLQYLPIGSLLMFSLVSKANYDFVRDQ 43
                8*****************************999988886 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.6   0.6    0.0079        47      13      30 ..     182     202 ..     171     206 .. 0.72
   2 ?    2.3   0.0     0.041   2.4e+02      21      29 ..     275     284 ..     253     300 .. 0.78
   3 ?    1.2   0.0     0.091   5.4e+02       1      30 [.     278     311 ..     278     319 .. 0.53
   4 ?    3.8   0.0     0.014        84      21      30 ..     390     400 ..     382     408 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0079
                 --E-S-HH...H-TT--EEE- CS
       LRR_4  13 ltdiplle...klpnLkeLdL 30 
                 lt   ll+   kl+nL++L+L
  EFC36808.1 182 LTRSKLLKimtKLKNLESLNL 202
                 555555556668********9 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.041
                 H.-TT--EEE CS
       LRR_4  21 k.lpnLkeLd 29 
                 + +pnL++L+
  EFC36808.1 275 SfCPNLEHLH 284
                 4489999997 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.091
                 SS--EEE--SS-..--E-S-....HHH.-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNq..ltdipl....lek.lpnLkeLdL 30 
                 pnLe+L++   +  + d  +    l+k +p++k+L +
  EFC36808.1 278 PNLEHLHFVC-ResVDD--NmlehLAKyCPKMKYLKI 311
                 5666666551.212333..222225555777777766 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.014
                 H.-TT--EEE- CS
       LRR_4  21 k.lpnLkeLdL 30 
                 + +pnL++Ld+
  EFC36808.1 390 NtNPNLEYLDI 400
                 4499*****98 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   2.4e-05      0.15       2      37 ..       7      42 ..       6      49 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.4e-05
  F-box-like  2 srLPdEiLlqIFsyLppsdLlrlalVCrrWrrvald 37
                s+LP + L+ +++yLp  +Ll  +lV++  +++++d
  EFC36808.1  7 SDLPQDELSVVLQYLPIGSLLMFSLVSKANYDFVRD 42
                79***************************9999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (436 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       520  (0.0290033); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 2894.53
//
Query:       EFC36809.1  [L=1032]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.9e-16   58.7   0.0    2.6e-15   56.9   0.0    2.1  1  Methyltransf_25  Methyltransferase domain
    6.4e-15   55.6   0.0    1.6e-14   54.3   0.0    1.8  1  Methyltransf_11  Methyltransferase domain
    1.1e-12   47.8   0.2    9.8e-12   44.7   0.2    2.3  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
    1.9e-10   40.8   0.0    4.5e-10   39.6   0.0    1.6  1  Methyltransf_23  Methyltransferase domain
    4.6e-10   39.5   0.8    2.8e-09   37.0   0.0    2.6  3  Methyltransf_31  Methyltransferase domain
    1.6e-08   35.2   0.0    1.6e-08   35.2   0.0    2.8  3  Methyltransf_12  Methyltransferase domain


Domain annotation for each model (and alignments):
>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.9   0.0   8.6e-19   2.6e-15       1      97 []      70     178 ..      70     178 .. 0.83

  Alignments for each domain:
  == domain 1  score: 56.9 bits;  conditional E-value: 8.6e-19
                      EEEET-TTSHHHHHHHCTS.....TSSEEEEEESSHHHHHHHHHHHHH...TTT.......TEEEEESBCCGBSSSTTTEEEEEEEST.GGGSS CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrl.....gkakvtgvDiseemleaareraee...egl.......nvefvqgdaedlpfedgsfDlvvssga.lhhls 78 
                      +Ld+++GtG + +++ ++        +++ g+D++++m+e a+ + ++   e         +++f+++d +dl+f d+sfD+v+s+++ l +  
       EFC36809.1  70 ILDVATGTGLVPFKFIDENivsfdRISSLNGIDFAPNMIEGAEYKKQArmeE-KkdefdwdKLKFQVMDGQDLKFSDESFDIVYSNMGvLFY-- 160
                      8***************99555444489************9998444443331.23456889************************9884544.. PP

                      HHHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  79 dedlekalkeiarvLkpgG 97 
                       +++ + l+ei+rvLk+gG
       EFC36809.1 161 -PKMVQGLSEIRRVLKKGG 178
                      .5799*************9 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.3   0.0   5.4e-18   1.6e-14       1      95 [.      71     181 ..      71     182 .. 0.86

  Alignments for each domain:
  == domain 1  score: 54.3 bits;  conditional E-value: 5.4e-18
                      EEET-TTSHHHHHHH.......HTTSEEEEEES-HHHH......HHHHHHCCHHT-...EEEETTEECCCTSS-TT-EEEEEEES-CCC-CCHH CS
  Methyltransf_11   1 LdvGcGtGrlaeala.......krgarvvgvDlskeml......klakekaseegl...kvefvvadaeklpfednsfDlvvssevlhhvedpe 78 
                      Ldv++GtG++  ++        +r +++ g+D++++m+      k+a+++ +++++   k++f+v+d ++l+f d+sfD+v+s++ + + +++ 
       EFC36809.1  71 LDVATGTGLVPFKFIdenivsfDRISSLNGIDFAPNMIegaeykKQARMEEKKDEFdwdKLKFQVMDGQDLKFSDESFDIVYSNMGVLFYPKMV 164
                      89999999999999965554444449************666655555666666666***9********************************** PP

                      HHHHHHHHHEEEEEEEE CS
  Methyltransf_11  79 kalkeiaRvLkpgGllv 95 
                      + l+ei+RvLk+gG+ +
       EFC36809.1 165 QGLSEIRRVLKKGGMAF 181
                      **************986 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.7   0.2   3.3e-15   9.8e-12      42     149 ..      61     180 ..      48     244 .. 0.84

  Alignments for each domain:
  == domain 1  score: 44.7 bits;  conditional E-value: 3.3e-15
                      H--S--TTEEEEES-TT-HHHHHHHHHHHHHH....EEEEEES-HHHHHHHH..HHHHHHTSS......TEEEEE--TTT-TTS-T-EEEEEEE CS
  Ubie_methyltran  42 lvavkrgakvlDvagGtgDlafklsdsvgekg....kvvvlDinenmLkvge..kklkeegki......nieflqanaeeLpfeddsfDvvtvs 123
                       +++ +  ++lDva+Gtg + fk+ d+   ++     ++++D+ +nm++ +e  k+++ e k+      +++f + ++++L+f+d+sfD+v   
       EFC36809.1  61 STTQENLVSILDVATGTGLVPFKFIDENIVSFdrisSLNGIDFAPNMIEGAEykKQARMEEKKdefdwdKLKFQVMDGQDLKFSDESFDIVYSN 154
                      445555569***************99988888778899**********988621334444444578888999********************** PP

                      S-GGG-S-HHHHHHHHHHHEEEEEEE CS
  Ubie_methyltran 124 fGlrnvtDklkaLkeayrvlkpGGrl 149
                       G+   + + ++L e++rvlk GG  
       EFC36809.1 155 MGVLFYPKMVQGLSEIRRVLKKGGMA 180
                      ************************75 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.6   0.0   1.5e-13   4.5e-10      19     164 ..      63     234 ..      41     235 .. 0.81

  Alignments for each domain:
  == domain 1  score: 39.6 bits;  conditional E-value: 1.5e-13
  Methyltransf_23  19 klraggrvLdiGcGtG.illevlren..gf....svtgvDlspeaveiae..............kakkaqkdqfdeqeaaepqgkfdlIvlrev 91 
                      +++   ++Ld+++GtG    + + en   f    s+ g+D  p+++e ae                +k +++ +d q+ ++++++fd+++++++
       EFC36809.1  63 TQENLVSILDVATGTGlVPFKFIDENivSFdrisSLNGIDFAPNMIEGAEykkqarmeekkdefDWDKLKFQVMDGQDLKFSDESFDIVYSNMG 156
                      2344449*********445666677633235566999*************************9999999999999******************* PP

  Methyltransf_23  92 lehvpdppellrqiatllkpgGylllseplaslkedrllldwlylvpag.....rhisffsarslkelleeaGlevve 164
                          p +   l+ i++ lk gG ++l  ++ + + +  ++ +    +++      ++s+++ + ++e ++eaG+e+ve
       EFC36809.1 157 VLFYPKMVQGLSEIRRVLKKGGMAFLNAWTGDFPTRVGFHAVFDVLQKDdryalPVFSLQDPKIFEERCKEAGFENVE 234
                      ********************************99999999974433333233335669999999************97 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   0.0   9.3e-13   2.8e-09       5     106 ..      68     179 ..      64     206 .. 0.86
   2 ?   -0.7   0.1      0.37   1.1e+03      45      67 ..     222     245 ..     219     336 .. 0.71
   3 ?   -3.1   0.0         2   6.1e+03      84     111 ..     478     506 ..     455     522 .. 0.73

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 9.3e-13
  Methyltransf_31   5 lrvlDlGCGtGeltfelae...elgp..kae.vvGiDiseeaielAre......naqklgld..nveFeqgdieeleklledekfDlilsnevl 84 
                      +++lD+++GtG   f++ +      +  ++  + GiD+ +++ie A+       + +k ++d   ++F++ d ++l+  ++de+fD++ sn  +
       EFC36809.1  68 VSILDVATGTGLVPFKFIDeniV--SfdRISsLNGIDFAPNMIEGAEYkkqarmEEKKDEFDwdKLKFQVMDGQDLK--FSDESFDIVYSNMGV 157
                      789****************6442..22233369***********99877777776677888888*************..************888 PP

  Methyltransf_31  85 naladpdkileeiervlkpggi 106
                         + + + l ei rvlk+gg 
       EFC36809.1 158 LFYPKMVQGLSEIRRVLKKGGM 179
                      899****************996 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.37
  Methyltransf_31  45 renaqklgldnveFeqgdiee.le 67 
                      +e++++ g++nve +q      l+
       EFC36809.1 222 EERCKEAGFENVEIKQVTQSLkLK 245
                      578999999999988854333244 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2
  Methyltransf_31  84 l.naladpdkileeiervlkpggillied 111
                        n++ d++k le +e +++ +g +++++
       EFC36809.1 478 SmNDFFDKEKRLEFLELAFHREGLFATSH 506
                      24888888888888888888888887654 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2   0.0   5.2e-12   1.6e-08       1      98 [.      71     179 ..      71     180 .. 0.89
   2 ?   -3.1   0.4       4.6   1.4e+04      44      59 ..     459     474 ..     453     482 .. 0.55
   3 ?   -2.6   1.1       3.3   9.8e+03      45      52 ..     678     685 ..     659     705 .. 0.53

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 5.2e-12
  Methyltransf_12   1 LeiGcGtGsllrallekl....pdieyt.gvDispsaiedakeklakrennnnnnvelealdlldldgg......ssfDlvvas.nvlhhlkdi 82 
                      L++ +GtG + + + +++     +i+ + g+D+ p++ie a+ k ++r +++ +++++++l     dg+      +sfD+v+++ +vl + +++
       EFC36809.1  71 LDVATGTGLVPFKFIDENivsfDRISSLnGIDFAPNMIEGAEYKKQARMEEKKDEFDWDKLKFQVMDGQdlkfsdESFDIVYSNmGVLFY-PKM 163
                      89*************9999***7777777*********888888888888888888888888777777788888**********899999.8** PP

  Methyltransf_12  83 revldnirklLkpgGr 98 
                       + l++ir++Lk+gG+
       EFC36809.1 164 VQGLSEIRRVLKKGGM 179
                      ***************7 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 4.6
  Methyltransf_12  44 ennnnnnvelealdll 59 
                       nnnnn ++++ +d +
       EFC36809.1 459 TNNNNNTINNNRIDFA 474
                      4455555555555544 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 3.3
  Methyltransf_12  45 nnnnnnve 52 
                      nnnn+ ++
       EFC36809.1 678 NNNNTTNN 685
                      22222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1032 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1430  (0.079759); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.97u 0.31s 00:00:01.28 Elapsed: 00:00:00.54
# Mc/sec: 5804.15
//
Query:       EFC36810.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.53    9.7   9.0       0.68    9.3   9.0    1.2  1  SDA1      SDA1


Domain annotation for each model (and alignments):
>> SDA1  SDA1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   9.0   3.8e-05      0.68     108     223 ..      73     197 ..      60     264 .. 0.53

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 3.8e-05
        SDA1 108 sdddseedseggwidvesdeeeieesdesedeeeeeeeeeekeekeeeeeeeeeeeeeeeeeeeeeekekkkk..............kakeaseeekkk 192
                 s+++s + s+  + + ++dee+i++s+ ++d+ ++ ++e+++  +  +e ee  ee+++ee  ++ +++                  +  ++s ++ +k
  EFC36810.1  73 SHSNS-SGSSSLFKNLNDDEESINSSS-DDDDYDDYNDEDGQLTDG-GEYEE-YEEDNDEEMIHNINES---IqlqqppsskrvkrsT--STSLSSGQK 162
                 43444.444456888999999888777.566655555444444333.33332.2333333333332222...1223455555555331..222222222 PP

        SDA1 193 e....keeekiskaselattrILTpaDFaklkelr 223
                 +    +  e+ s+++  + t  LT+ D  ++    
  EFC36810.1 163 KpiitRIIEEYSENEIQQDTNFLTNYDISAIFSSL 197
                 20000122333333334455566666666665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1568  (0.0874561); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1897.09
//
Query:       EFC36811.1  [L=313]
Description: lipase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-20   72.7   0.0    5.2e-20   71.8   0.0    1.5  1  Lipase_3  Lipase (class 3)
    0.00024   20.7   0.1    0.00035   20.2   0.1    1.3  1  DUF2974   Protein of unknown function (DUF2974)


Domain annotation for each model (and alignments):
>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.8   0.0   5.8e-24   5.2e-20       1     129 [.     134     259 ..     134     278 .. 0.92

  Alignments for each domain:
  == domain 1  score: 71.8 bits;  conditional E-value: 5.8e-24
                 EEEE----..------------EEE-HHHH-GTT-EEEHHHHHHHHS-HHHHHHHHHHHHHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS..-- CS
    Lipase_3   1 vvafRGte..sakdwltdldfslteakellekeggkvhsgfleayeeslreqvlkelkrllekypeysivvtGHSLGgalAlLaaldlvengene..kk 95 
                 +v+f+Gt+  +  dw+++l++ +++++   +   + vh+gfl+ y    r+++++++k+l   ++   i + GHS Gg+l+ Laa+d+   g++   k 
  EFC36811.1 134 IVSFKGTQmnDPVDWANNLKTAFSSFQIGSS--AYAVHTGFLSEYL-VDRQNIFDTIKSLGLLNE---IGFYGHSQGGSLSELAAVDYLGSGKRPetKA 226
                 589*****98999**************9855..9************.99**********999999...***********************9998999* PP

                 -EEEEEES----B-HHHHHHHHT-TTEEEEEEEE CS
    Lipase_3  96 kvtvvtfGqPrvgnkefaklvdsqlnkkvlrvvn 129
                 +++vvtfGqPrvg+ +fa   + q+n +++rv++
  EFC36811.1 227 TIKVVTFGQPRVGDANFAAKSN-QVNPNFVRVIT 259
                 ********************99.77777999986 PP

>> DUF2974  Protein of unknown function (DUF2974)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.1     4e-08   0.00035      23     104 ..     117     214 ..      97     260 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 4e-08
     DUF2974  23 eqkqfaaatfrleedtlvvaFRGTd.dtlvgWkedfnmafrs.evpaqesAlk..Ylnkileeseg............kiylgGhSkGGnlAvyaamn 104
                  +     + f+ + ++++v+F+GT+ +  v+W ++++ af+s ++ +   A++  +l++ l   ++            +i   GhS+GG+l  +aa++
  EFC36811.1 117 AKATNCKVYFNSATKSAIVSFKGTQmNDPVDWANNLKTAFSSfQIGSSAYAVHtgFLSEYLVDRQNifdtikslgllnEIGFYGHSQGGSLSELAAVD 214
                 44444567899999**********84568***********864667777775333666665555557777888****88****************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 1858.81
//
Query:       EFC36812.1  [L=788]
Description: Pumilio/Puf RNA-binding protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-66  216.9  15.7    5.6e-08   32.1   0.0    8.5  8  PUF             Pumilio-family RNA binding repeat
    2.3e-05   24.8   3.0        0.2   12.0   0.6    4.2  4  CPL             CPL (NUC119) domain
  ------ inclusion threshold ------
      0.019   15.0   0.3      0.073   13.1   0.3    2.0  1  Tk-SP_N-pro     Tk-SP N-propeptide domain
      0.021   15.0   3.6       0.95    9.7   0.4    4.0  3  SAC3            Leucine permease transcriptional regulator he
      0.086   13.3   0.6       0.99    9.9   0.2    2.8  2  PNPase          Polyribonucleotide nucleotidyltransferase, RN


Domain annotation for each model (and alignments):
>> PUF  Pumilio-family RNA binding repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.0   3.7e-10   1.3e-06       2      35 .]     462     495 ..     461     495 .. 0.95
   2 !   32.1   0.0   1.5e-11   5.6e-08       1      34 [.     497     530 ..     497     531 .. 0.91
   3 !   22.4   0.1   1.9e-08   6.7e-05       1      32 [.     533     564 ..     533     567 .. 0.89
   4 !   30.4   0.1   5.1e-11   1.8e-07       2      35 .]     570     603 ..     569     603 .. 0.91
   5 !   23.9   0.0   6.2e-09   2.2e-05       2      30 ..     606     634 ..     605     639 .. 0.85
   6 !   30.6   0.0   4.6e-11   1.6e-07       1      35 []     641     675 ..     641     675 .. 0.95
   7 !   24.0   0.1   5.4e-09   1.9e-05       2      34 ..     678     710 ..     677     711 .. 0.91
   8 !   29.9   0.1   7.8e-11   2.8e-07       9      34 ..     731     756 ..     728     757 .. 0.94

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 3.7e-10
                 HGGGHHHHHTSTTHHHHHHHHHHHSCHHHHHHHH CS
         PUF   2 ikgnlvqLstdqyGnyvvQkllehateeqkklil 35 
                 i g++v+ s dq+G++++Q+ le+a+ ++k+li+
  EFC36812.1 462 IVGHVVEFSRDQHGSRFIQQKLEKASNSEKELIF 495
                 679****************************997 PP

  == domain 2  score: 32.1 bits;  conditional E-value: 1.5e-11
                 HHGGGHHHHHTSTTHHHHHHHHHHHSCHHHHHHH CS
         PUF   1 sikgnlvqLstdqyGnyvvQkllehateeqkkli 34 
                 +i+++ ++L+td +Gnyv+Qk++e    +qkk++
  EFC36812.1 497 EIQPYALSLMTDVFGNYVIQKFFEFGNAPQKKKL 530
                 689**********************999998865 PP

  == domain 3  score: 22.4 bits;  conditional E-value: 1.9e-08
                 HHGGGHHHHHTSTTHHHHHHHHHHHSCHHHHH CS
         PUF   1 sikgnlvqLstdqyGnyvvQkllehateeqkk 32 
                 +++gn++ L    yG++v+Qk le+ +  +k+
  EFC36812.1 533 ELQGNVLNLTLQTYGCRVIQKALEVIDNDDKD 564
                 5799********************98887776 PP

  == domain 4  score: 30.4 bits;  conditional E-value: 5.1e-11
                 HGGGHHHHHTSTTHHHHHHHHHHHSCHHHHHHHH CS
         PUF   2 ikgnlvqLstdqyGnyvvQkllehateeqkklil 35 
                 +kgn+  +++dq+Gn+v+Qk++e+ +++ +++i+
  EFC36812.1 570 LKGNVMRCVQDQNGNHVIQKCIERVPPKIIQFIV 603
                 678888899**********************995 PP

  == domain 5  score: 23.9 bits;  conditional E-value: 6.2e-09
                 HGGGHHHHHTSTTHHHHHHHHHHHSCHHH CS
         PUF   2 ikgnlvqLstdqyGnyvvQkllehateeq 30 
                 +kg++ + +++ yG++v+Q++leh+te q
  EFC36812.1 606 FKGKVYEQAIHNYGCRVIQRILEHCTEGQ 634
                 6778888899***************9866 PP

  == domain 6  score: 30.6 bits;  conditional E-value: 4.6e-11
                 HHGGGHHHHHTSTTHHHHHHHHHHHSCHHHHHHHH CS
         PUF   1 sikgnlvqLstdqyGnyvvQkllehateeqkklil 35 
                 +i++n++ L++d+yGnyvvQ++l++ +++ k+li+
  EFC36812.1 641 EILDNILALVVDPYGNYVVQHVLDRGKPTFKSLII 675
                 5899***************************9996 PP

  == domain 7  score: 24.0 bits;  conditional E-value: 5.4e-09
                 HGGGHHHHHTSTTHHHHHHHHHHHSCHHHHHHH CS
         PUF   2 ikgnlvqLstdqyGnyvvQkllehateeqkkli 34 
                 +++++++Ls+++++++v++k+++ a +++++++
  EFC36812.1 678 LSKKIQELSINKFASNVIEKCFQQANKKERDNM 710
                 6899*******************9999998877 PP

  == domain 8  score: 29.9 bits;  conditional E-value: 7.8e-11
                 HHTSTTHHHHHHHHHHHSCHHHHHHH CS
         PUF   9 LstdqyGnyvvQkllehateeqkkli 34 
                 +++dq++nyv+Qk++e+++ +q+k i
  EFC36812.1 731 MMKDQFANYVIQKIIETCDASQRKTI 756
                 79*********************988 PP

>> CPL  CPL (NUC119) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.68   2.4e+03      63      95 ..     462     494 ..     458     511 .. 0.81
   2 !    6.1   0.0    0.0038        13      58     120 ..     529     589 ..     524     601 .. 0.78
   3 ?    3.7   0.0      0.02        72      58     104 ..     597     652 ..     591     665 .. 0.69
   4 !   12.0   0.6   5.5e-05       0.2      56     133 ..     671     747 ..     667     757 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.68
         CPL  63 iaknaeellsdnlgsqfvaevLlsaegdkqeai 95 
                 i  ++ e+ +d+ gs f+++ L++a++ ++e+i
  EFC36812.1 462 IVGHVVEFSRDQHGSRFIQQKLEKASNSEKELI 494
                 56678888899999********99999888655 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0038
         CPL  58 allsaiaknaeellsdnlgsqfvaevLlsaegdkqeaieaiaklakgdlvaeekdeelhliek 120
                 +l + ++ n+ +l+ ++ g+ +++++L+  ++d+++ +  + +l  + +   ++++ +h+i+k
  EFC36812.1 529 KLSKELQGNVLNLTLQTYGCRVIQKALEVIDNDDKDTV--VSELKGNVMRCVQDQNGNHVIQK 589
                 57788999999*********************999877..44544444455569999999987 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.02
         CPL  58 allsaia....knaeellsdnlgsqfvaevLlsaegdkq.....eaieaiaklakg 104
                 ++++ i      ++ e   +n g+ +++ +L+++++ ++     e++++i++l+ +
  EFC36812.1 597 KIIQFIVdgfkGKVYEQAIHNYGCRVIQRILEHCTEGQTvpilqEILDNILALVVD 652
                 55555553333445555667899********9999988887777777777766655 PP

  == domain 4  score: 12.0 bits;  conditional E-value: 5.5e-05
         CPL  56 spallsaiaknaeellsdnlgsqfvaevLlsaegdkqeaieaiaklakgdlvaee..kdeelhliekpfgsrlLKaLiqg 133
                    ++ a++k+++el  ++++s ++ ++ ++a++++++ +  i +l+ gd+++ +  ++  + +++++f++ +++++i+ 
  EFC36812.1 671 KSLIIAALSKKIQELSINKFASNVIEKCFQQANKKERDNM--ITELI-GDITSRDisETPLFAMMKDQFANYVIQKIIET 747
                 667899****************************999766..44444.333444434788899999***********985 PP

>> Tk-SP_N-pro  Tk-SP N-propeptide domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.3     2e-05     0.073       4      49 ..     672     719 ..     670     733 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2e-05
                  TTB-HHHHHHHHTS-TT-EEEEEE..EESSHHHHHHHHHHHHHCT-EE CS
  Tk-SP_N-pro   4 glltpgLfkKiqklndneeistii..vFknkadkekavkvleilGaki 49 
                   l++  L+kKiq+l++n+  s +i   F++   ke+   + e++G  +
   EFC36812.1 672 SLIIAALSKKIQELSINKFASNVIekCFQQANKKERDNMITELIGDIT 719
                  588999******************778******************855 PP

>> SAC3  Leucine permease transcriptional regulator helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.2      0.17     6e+02      10      32 ..     563     585 ..     554     594 .. 0.77
   2 ?    3.3   0.0     0.027        96       2      44 ..     640     681 ..     639     684 .. 0.92
   3 ?    9.7   0.4   0.00026      0.95       5      41 ..     679     714 ..     675     725 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.17
                 HHHHHHHHHHHHHHHHHHHH... CS
        SAC3  10 qdvVdselekilknllkeenrkn 32 
                 +d+V sel+  + ++++++n + 
  EFC36812.1 563 KDTVVSELKGNVMRCVQDQNGNH 585
                 79999**************9544 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.027
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH...HHHHHHHHHHHH CS
        SAC3   2 kqitdeiiqdvVdselekilknllkeenrknerkqiIdsLsee 44 
                 ++i+d+i++ vVd   + +++ +l++ +  + +++iI  Ls+ 
  EFC36812.1 640 QEILDNILALVVDPYGNYVVQHVLDRGK-PTFKSLIIAALSKK 681
                 689************************9.8899****999975 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00026
                 HHHHHHHHHHHHHHHHHHHHHHHHH...HHHHHHHHH CS
        SAC3   5 tdeiiqdvVdselekilknllkeenrknerkqiIdsL 41 
                  ++i +  +++  ++++++++++ n k+er+++I++L
  EFC36812.1 679 SKKIQELSINKFASNVIEKCFQQAN-KKERDNMITEL 714
                 567777789999*************.99******998 PP

>> PNPase  Polyribonucleotide nucleotidyltransferase, RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.43   1.6e+03      14      45 ..     551     582 ..     545     622 .. 0.74
   2 ?    9.9   0.2   0.00028      0.99       5      42 ..     686     723 ..     683     766 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.43
                 HHHHTTSSSHHHHHHHHHHHHHHHHHHHH... CS
      PNPase  14 isealtiteKqeRyaaldeikekvveafaael 45 
                 i++al++ + ++ ++ + e+k +v+  ++ + 
  EFC36812.1 551 IQKALEVIDNDDKDTVVSELKGNVMRCVQDQN 582
                 77888888888888888888888888777443 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00028
                 HHHTTTHHHHHHHTTSSSHHHHHHHHHHHHHHHHHHHH CS
      PNPase   5 kvaelaeerisealtiteKqeRyaaldeikekvveafa 42 
                 +++++a++ i++ +++ +K+eR++ + e+  +++ + +
  EFC36812.1 686 SINKFASNVIEKCFQQANKKERDNMITELIGDITSRDI 723
                 6999**********************999888776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (788 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1606  (0.0895755); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.87u 0.33s 00:00:01.20 Elapsed: 00:00:00.56
# Mc/sec: 4249.52
//
Query:       EFC36813.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1179  (0.0657594); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.49
# Mc/sec: 2390.18
//
Query:       EFC36814.1  [L=343]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.8e-47  160.0   6.4    8.6e-45  153.5   1.9    2.4  3  Peptidase_C1    Papain family cysteine protease
    0.00024   20.9   0.4    0.00085   19.2   0.4    1.9  2  Propeptide_C1   Peptidase family C1 propeptide
  ------ inclusion threshold ------
       0.25   10.1   0.0       0.25   10.1   0.0    3.2  4  Peptidase_C1_2  Peptidase C1-like family


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       1.7     1e+04     129     154 ..      27      51 ..      13      61 .. 0.56
   2 !  153.5   1.9   1.4e-48   8.6e-45       2     191 ..      85     284 ..      84     298 .. 0.91
   3 !    8.5   0.0   0.00031       1.9     172     191 ..     306     327 ..     302     330 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 1.7
                   HHHHSSEEEEEECCSHHHHTEESSEE CS
  Peptidase_C1 129 lakngPvsvaidaseedfqlYksGvy 154
                   +++n   s   +++e+ f++ + G +
    EFC36814.1  27 INNNPKSSWKAKVYEK-FANMTVGEF 51 
                   4443334444455552.555555544 PP

  == domain 2  score: 153.5 bits;  conditional E-value: 1.4e-48
                   TSCEETTTTTTG.SG---B-TSSBTHHHH........HHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTT CS
  Peptidase_C1   2 pesvDwrekgga.vtpvkdqgsCGsCWaf........savgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekd 88 
                   p+++D r+k  + v++v++q +CGsCWaf        sa+++l+dr++i+++ + +v +S q  +dC+   n gC+GG   ++++++++ g v+e++
    EFC36814.1  85 PTNFDSRQKWPQcVHTVRNQLDCGSCWAFwiefndlvSATKVLSDRFCIASNgSVNVIMSPQYQIDCNM-DNLGCSGGSLPKTWNFLTNVGSVSEQC 180
                   89******87667***************888888888***************999************97.899************************ PP

                   S--SSSCSSS-CGCGGGSE...EBEESEEEEEESSBHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEEEEEET..TEE CS
  Peptidase_C1  89 ypYkakeggkCkkkkkkek...vakikgygkvkenseealkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivGygven..gkk 180
                    pYk++++  C +k  + k    +k k+y ++k    ++++ +++++gPv++++++++ d+++Y+sGvy++ + + +   ha++i+G+g ++  +k+
    EFC36814.1 181 RPYKNNDDDDCPSKCVDGKapsFYKAKSYASIKGL--DSIMYEIQNYGPVHASLTVYK-DLMSYQSGVYSHLTGN-EIGGHAIVIIGFGMDSlsKKP 273
                   ****9999888888555454677899999999985..99*******************.6***********7555.4789***********999*** PP

                   EEEEE-SBTTT CS
  Peptidase_C1 181 yWivkNsWgtd 191
                   yWi++NsWg++
    EFC36814.1 274 YWIIANSWGEN 284
                   *********97 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00031
                   EEEEET..TEEEEEEE-SBTTT CS
  Peptidase_C1 172 Gygven..gkkyWivkNsWgtd 191
                   G+g ++  +k++W v+NsW+++
    EFC36814.1 306 GFGDDSqtKKPCWTVANSWSEK 327
                   6666555599*********975 PP

>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.4   1.4e-07   0.00085       6      32 ..      24      53 ..      21      61 .. 0.91
   2 ?   -1.9   0.0      0.53   3.1e+03      29      38 ..     333     342 ..     318     343 .] 0.79

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 1.4e-07
                   HHHHHHC.T-SEEE---..-SSBSHHHHHC CS
  Propeptide_C1  6 IdyiNsk.nttWkAgrN..Fdnttlsyikg 32
                   I++iN++ +++WkA+ +  F+n t++++k+
     EFC36814.1 24 IHSINNNpKSSWKAKVYekFANMTVGEFKQ 53
                   99***********************99996 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.53
                    HHHCCS-B-- CS
  Propeptide_C1  29 yikgLlGvlp 38 
                    ++k +lG +p
     EFC36814.1 333 ELKEMLGLHP 342
                    6899**9887 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.11   6.7e+02     230     256 ..      36      62 ..      34      70 .. 0.83
   2 ?   -0.5   0.7     0.069   4.1e+02      57      70 ..     100     113 ..      91     120 .. 0.89
   3 ?   10.1   0.0   4.2e-05      0.25     358     388 ..     254     284 ..     244     296 .. 0.87
   4 ?   -0.7   0.1     0.077   4.6e+02     371     389 ..     310     328 ..     305     330 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.11
                     TTS-EEEEEEE-HHHHHHHCTTS-CCC CS
  Peptidase_C1_2 230 kdknyhkekdltpkeFyekyvkldled 256
                     k k y+k+ ++t  eF +ky++   e+
      EFC36814.1  36 KAKVYEKFANMTVGEFKQKYLGAIHEE 62 
                     56889***************9865555 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.069
                     S--B--BSSTHHHH CS
  Peptidase_C1_2  57 evtnqkqsGRCWlF 70 
                      v nq   G CW F
      EFC36814.1 100 TVRNQLDCGSCWAF 113
                     689*********99 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 4.2e-05
                     ---EEEEEEEEEE-TTSSEEEEEEE-SBTTT CS
  Peptidase_C1_2 358 lmtHamvltgvdvdddgkvtkwkvEnsWGed 388
                     +  Ha+v++g+ +d+  k   w + nsWGe+
      EFC36814.1 254 IGGHAIVIIGFGMDSLSKKPYWIIANSWGEN 284
                     567**********999*************97 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.077
                     -TTSSEEEEEEE-SBTTTS CS
  Peptidase_C1_2 371 dddgkvtkwkvEnsWGeds 389
                     d++ k   w v nsW e++
      EFC36814.1 310 DSQTKKPCWTVANSWSEKE 328
                     45566677*******9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       392  (0.021864); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2176.98
//
Query:       EFC36815.1  [L=429]
Description: hypothetical protein NAEGRDRAFT_82106 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (429 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1802  (0.100508); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.82u 0.30s 00:00:01.11 Elapsed: 00:00:00.48
# Mc/sec: 2683.95
//
Query:       EFC36816.1  [L=341]
Description: patatin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-22   80.6   0.3    3.7e-22   79.5   0.3    1.6  1  Patatin   Patatin-like phospholipase


Domain annotation for each model (and alignments):
>> Patatin  Patatin-like phospholipase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5   0.3   2.1e-26   3.7e-22       1     201 [.      59     232 ..      59     235 .. 0.94

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 2.1e-26
     Patatin   1 LvlsGGGsrgafslgalkaLkkelgerfdiisGtSaGAiialllalg..rdpaalvddlrnlllnkifdrdllirelaanlaarlsgllgkgglfdaea 97 
                 L+l+GGG rga+++g+lk+L   +  +  +i+G SaGAi++ +l+++  +d +a v+++ n +l++ ++       ++ ++  +  g+l k+glf++ +
  EFC36816.1  59 LALGGGGDRGAYEAGVLKYL---EQVQYQVIGGISAGAINSVALSQYkiGDEKAAVAFILNKWLSLQKSQV-----YKDWPLGIAEGFLIKSGLFNTSP 149
                 89******************...99999*******************99999999*********9999999.....99********************* PP

     Patatin  98 lrellrkvladktlkrlsarlgklpllkslftanqavpaittataatastanranglytedddddvdladavraSsafPglfppvsldge....lyvDG 192
                 l ++l++ ++  +++   + l                             +n  ++ y   d ++ dl++a raSsa+Pg+f++v l+ +    lyvDG
  EFC36816.1 150 LHNFLTANVNVTKIRQSGRSLLLG-------------------------ATNLVTNSYERFDQFTDDLIEATRASSAVPGVFEAVPLTKNgkesLYVDG 223
                 ******999988888888888888.........................579999999999999***********************888889****** PP

     Patatin 193 GilsNvPil 201
                 G    +P+ 
  EFC36816.1 224 GAKYMTPVS 232
                 *99999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       417  (0.0232584); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.36s 00:00:01.02 Elapsed: 00:00:00.56
# Mc/sec: 1821.09
//
Query:       EFC36817.1  [L=657]
Description: Hypothetical protein NAEGRDRAFT_75486 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0015   17.4   0.0     0.0028   16.5   0.0    1.4  1  UNC-79    Cation-channel complex subunit UNC-79


Domain annotation for each model (and alignments):
>> UNC-79  Cation-channel complex subunit UNC-79
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   1.6e-07    0.0028     406     455 ..     257     307 ..     212     330 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1.6e-07
      UNC-79 406 mlFqWFav.taylpddqaestleklktefvcdWlkevikthyevfvscLlP 455
                 +lF+W ++ +a+ p d+ +++le+  t +++  l++vi++hy+++ +cL  
  EFC36817.1 257 ILFEWLESiIACPPFDSSQTSLEEWSTRMLTSSLENVIQSHYSMYKKCLND 307
                 8*****852688888*********************************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (657 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       696  (0.0388198); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.48
# Mc/sec: 4076.31
//
Query:       EFC36818.1  [L=268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    8.5e-15   55.0   0.7    8.5e-15   55.0   0.7    1.7  2  EAF         RNA polymerase II transcription elongation factor
  ------ inclusion threshold ------
       0.51   10.0   7.6       0.75    9.5   7.6    1.3  1  Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein


Domain annotation for each model (and alignments):
>> EAF  RNA polymerase II transcription elongation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.0   0.7   9.5e-19   8.5e-15       1      94 [.      10     114 ..      10     118 .. 0.81
   2 ?   -3.3   0.0       1.4   1.2e+04      29      42 ..     125     138 ..     124     162 .. 0.64

  Alignments for each domain:
  == domain 1  score: 55.0 bits;  conditional E-value: 9.5e-19
         EAF   1 Ypiklgssllnal.kssksefvairYnfkPasvdqsk.egtlkqsssenkevsvelsfsd..t......FeGseqpa...kekdcvLvfdeetkeftLe 86 
                 Y+i++g++++n++ +ss++e++++ +nfkP++ ++++ eg+ +  ss  +  s++ ++ +  t      F+Gs  p+   + ++cvL++d+ +++f+Le
  EFC36818.1  10 YKIEVGETISNNNtSSSNTEYHSLFFNFKPKTLKENNwEGSFDIDSSVVD--SYTSASPAtlTanskfvFKGSYVPNnksNVHECVLIYDRYSGTFRLE 106
                 9********998889999*****************999*****9444333..33333322221335688***99998888999**************** PP

         EAF  87 rldstvrl 94 
                 +l++t  +
  EFC36818.1 107 KLKATTGF 114
                 ***99876 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.4
         EAF  29 Pasvdqskegtlkq 42 
                 P+ +++s++g+lk+
  EFC36818.1 125 PSLAHSSSTGKLKT 138
                 55566666788877 PP

>> Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   7.6   8.4e-05      0.75     110     145 ..     228     266 ..     177     268 .] 0.46

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 8.4e-05
                 ----------------------...-------------- CS
  Cwf_Cwc_15 110 eidaddedseeeeeeeeeesdd...dsdsdsdddddede 145
                 eida    ++++ ++++++sd+   ++d ++d+d++ de
  EFC36818.1 228 EIDAKAALDDSSASDDSDSSDSdtsSDDTSDDSDSSSDE 266
                 555554444433333222222211122222333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       887  (0.0494729); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1742.41
//
Query:       EFC36819.1  [L=149]
Description: cofilin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.7e-24   85.3   0.6    3.1e-24   85.1   0.6    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.1   0.6   1.7e-28   3.1e-24       2     121 .]      12     143 ..      11     143 .. 0.93

  Alignments for each domain:
  == domain 1  score: 85.1 bits;  conditional E-value: 1.7e-28
                  HHHHHHHCTTT.....SSEEEEEEECTTTEEEEEESS-...HHHHHHHHHHTTT-EEEEEEEEEECCS.......ECCEEEEEEEEE--TTS-HHHHH CS
  Cofilin_ADF   2 keafkelksgk....ktkyilfkidddkeeivveeege...tyeelreelpeseprYavydveyehdd.......eskrsklvfIswvPdsapikqkm 85 
                  +++++e+++gk    ++k++++k+++ +  +++++e +   +++el+++lp ++ r+++y++++e ++       e+ r+k++fI+w+P+++++k+k 
   EFC36819.1  12 IKTYEEMRMGKgsnkDKKFLVLKMQESS--LQIDQELTqlsSLDELTANLPPKNSRFICYHLSFEMPSqnetslrEGIRTKMMFITWCPNDTNVKEKF 107
                  689**********9999*******9876..6666644556799***********************9999999999999******************* PP

                  HHHHHHHHHHHHCTTSEEEEEE-CGGCCSHHHHHHH CS
  Cofilin_ADF  86 lyasskdalkkelkgisveieatdldelteeelkek 121
                   +a++ +++k++l+g+s +i++++++e++e+++ ek
   EFC36819.1 108 QVAATVKTVKQKLNGLSATIHCSTKSEIDEKSMIEK 143
                  *******************************99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       815  (0.0454571); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 885.87
//
Query:       EFC36820.1  [L=470]
Description: leucine rich repeat domain protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-14   52.0  57.9    0.00012   22.4   4.6    9.6 12  LRR_4     Leucine Rich repeats (2 copies)
    6.9e-13   48.2  37.5    3.7e-06   26.6   3.2    8.5 10  LRR_8     Leucine rich repeat
    2.7e-12   45.7  40.3       0.11   12.6   0.0   10.8 11  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
      0.038   13.5   9.6        3.7    7.0   0.2    4.0  4  LRR_9     Leucine-rich repeat
        4.6    8.2  39.8        2.9    8.8   0.1   10.6 10  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.4      0.42   1.5e+03      23      33 ..      78      87 ..      48     108 .. 0.61
   2 !    6.4   7.2    0.0034        12       2      38 ..     103     141 ..      78     146 .. 0.83
   3 !   13.3   5.6   2.3e-05     0.083       1      32 [.     126     160 ..     126     167 .. 0.84
   4 !   11.9   4.7   6.8e-05      0.25       1      41 [.     177     219 ..     177     222 .. 0.83
   5 !   15.5   2.3   4.7e-06     0.017       3      35 ..     203     237 ..     201     247 .. 0.82
   6 !   13.7   1.1   1.7e-05     0.062       1      36 [.     226     261 ..     226     271 .. 0.80
   7 !   22.4   4.6   3.4e-08   0.00012       1      38 [.     276     312 ..     276     318 .. 0.85
   8 !    8.2   0.5   0.00098       3.5       1      36 [.     298     336 ..     298     348 .. 0.85
   9 ?    1.1   0.0      0.16   5.8e+02       1      15 [.     324     338 ..     324     371 .. 0.55
  10 !    7.3   0.4    0.0019       6.7      16      36 ..     375     394 ..     358     401 .. 0.71
  11 !    9.0   0.6   0.00053       1.9       2      39 ..     383     420 ..     382     428 .. 0.74
  12 !    5.2   0.1    0.0083        30       2      30 ..     409     442 ..     408     450 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.42
                TT--EEE-.-S CS
       LRR_4 23 pnLkeLdLsgN 33
                 n ++L+L  N
  EFC36820.1 78 RNIQSLTL-KN 87
                55555555.33 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0034
                 S--EEE--.SS-..--E-S-HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLs.nNq..ltdiplleklpnLkeLdLsgNnlitd 38 
                 +L++L++  + +  l+d++   +l++L++L+L +N++it+
  EFC36820.1 103 KLTSLHIViG-RlgLKDLEEVCSLKQLTSLSLRNNSQITN 141
                 6777777775.333888888556*********88999953 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 2.3e-05
                 SS--EEE--SS.---.E-S-.HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnN.qlt.dipl.leklpnLkeLdLsg 32 
                 ++L++L+L+nN q+t di   ++ l++L+ L+Lsg
  EFC36820.1 126 KQLTSLSLRNNsQITnDIYTnIAELKHLTRLNLSG 160
                 58*********99**887778667*********87 PP

  == domain 4  score: 11.9 bits;  conditional E-value: 6.8e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----GGG CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdlde 41 
                 + L++L+Ls +++   +l l + l  L++L+L g +++++l++
  EFC36820.1 177 TGLKSLNLSCCNIEAAQLnLIGtLSTLESLNLEGYTNLSTLES 219
                 67************999996666*********98766777765 PP

  == domain 5  score: 15.5 bits;  conditional E-value: 4.7e-06
                 --EEE--.SS---E-S-HH..H-TT--EEE-.-S-- CS
       LRR_4   3 LevLdLs.nNqltdiplle..klpnLkeLdLsgNnl 35 
                 Le+L+L   ++l++++++   ++p+L++L+L +N +
  EFC36820.1 203 LESLNLEgYTNLSTLESIDkwNMPSLTYLNL-ENRP 237
                 9******88********66679*********.7733 PP

  == domain 6  score: 13.7 bits;  conditional E-value: 1.7e-05
                 SS--EEE--SS---.E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLsgNnli 36 
                 p+L++L+L n   + +++   kl++L++L++s++  i
  EFC36820.1 226 PSLTYLNLENRPFSkSLGDVCKLTSLRTLNMSNC-GI 261
                 79*******8678866666446*********887.54 PP

  == domain 7  score: 22.4 bits;  conditional E-value: 3.4e-08
                 SS--EEE--SS---E-S-HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipllek.lpnLkeLdLsgNnlitd 38 
                 pnL++Ld s+N+l+ i+++++  pnL+ L+L+ +  i+d
  EFC36820.1 276 PNLTSLDASHNNLS-ISWFQNnAPNLTNLNLTCC-GIDD 312
                 8*************.99*9977*********444.6655 PP

  == domain 8  score: 8.2 bits;  conditional E-value: 0.00098
                 SS--EEE--SS---E-S-...HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl...lek.lpnLkeLdLsgNnli 36 
                 pnL++L+L  + + d +    +++  p+L  Ld+s+N  +
  EFC36820.1 298 PNLTNLNLTCCGIDDTEIiqlFSGiAPKLAILDVSEN-EV 336
                 8*********9****99966666999********999.33 PP

  == domain 9  score: 1.1 bits;  conditional E-value: 0.16
                 SS--EEE--SS---E CS
       LRR_4   1 pnLevLdLsnNqltd 15 
                 p+L +Ld s N +td
  EFC36820.1 324 PKLAILDVSENEVTD 338
                 567778888888665 PP

  == domain 10  score: 7.3 bits;  conditional E-value: 0.0019
                 -S-.HHH-TT--EEE-.-S--- CS
       LRR_4  16 ipl.leklpnLkeLdLsgNnli 36 
                 i++ ++ l nL++++ sgN +i
  EFC36820.1 375 ISNsPY-LENLTQINFSGN-QI 394
                 333355.***********9.55 PP

  == domain 11  score: 9.0 bits;  conditional E-value: 0.00053
                 S--EEE--SS---E-S-HH....H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplle....klpnLkeLdLsgNnlitdl 39 
                 nL+ +++s+Nq+   +ll+    +l nLk+L L +     ++
  EFC36820.1 383 NLTQINFSGNQIYAKGLLYlsqsSLVNLKVLKLCRT----NI 420
                 99*********8854554455645********9665....33 PP

  == domain 12  score: 5.2 bits;  conditional E-value: 0.0083
                 S--EEE--SS---E-S-HH.....H-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdiplle.....klpnLkeLdL 30 
                 nL+vL L  +++t+ ++ e     +++ L e+d 
  EFC36820.1 409 NLKVLKLCRTNITESSFREfmksgNMKRLCEIDF 442
                 9************888755555535666655555 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.85     3e+03       2      18 ..      48      64 ..      47      66 .. 0.81
   2 ?   -3.1   0.0       1.9   6.9e+03      49      56 ..      78      85 ..      73      89 .. 0.46
   3 !   12.3   3.6   3.1e-05      0.11      23      58 ..     124     160 ..     102     163 .. 0.74
   4 !   26.6   3.2     1e-09   3.7e-06       2      58 ..     178     235 ..     177     238 .. 0.94
   5 ?    4.0   0.0     0.012        43      44      61 .]     244     261 ..     239     261 .. 0.81
   6 !    4.9   0.6     0.006        21      48      61 .]     275     288 ..     268     295 .. 0.77
   7 !    9.0   0.0   0.00031       1.1       1      38 [.     298     337 ..     298     343 .. 0.89
   8 ?    2.3   0.1     0.039   1.4e+02      24      37 ..     381     394 ..     360     396 .. 0.75
   9 !    6.5   0.2     0.002       7.2      23      48 ..     406     431 ..     402     438 .. 0.81
  10 ?   -3.7   0.0         3   1.1e+04      15      28 ..     451     464 ..     450     465 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.85
                T-SEEE-TTS--SEE-T CS
       LRR_8  2 nLtsLdLsnNrltsldd 18
                n++sL+L++  + s+++
  EFC36820.1 48 NVRSLVLDFKLIPSINQ 64
                78999999998888876 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.9
                -S-.EEE- CS
       LRR_8 49 psLrsLdL 56
                ++++sL+L
  EFC36820.1 78 RNIQSLTL 85
                23333333 PP

  == domain 3  score: 12.3 bits;  conditional E-value: 3.1e-05
                 T-TT--EEE--SS.---GGGGGGGTT--S-.EEE--S CS
       LRR_8  23 glsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsg 58 
                 +l++L++L+L+nN ++t      ++ L++L+ L+Lsg
  EFC36820.1 124 SLKQLTSLSLRNNsQITNDIYTNIAELKHLTRLNLSG 160
                 5899999999999999997789999999999999997 PP

  == domain 4  score: 26.6 bits;  conditional E-value: 1e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--.SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLs.nNllttlspgafsgLpsLrsLdLsg 58 
                 +L+sL+Ls+ ++++ +     +ls L++L+L  + +l+tl+    +++psL++L+L++
  EFC36820.1 178 GLKSLNLSCCNIEAAQLNLIGTLSTLESLNLEgYTNLSTLESIDKWNMPSLTYLNLEN 235
                 79*****************************7256*********************97 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.012
                 GGTT--S-.EEE--SS-- CS
       LRR_8  44 afsgLpsLrsLdLsgNrL 61 
                     L+sLr L++s++ +
  EFC36820.1 244 DVCKLTSLRTLNMSNCGI 261
                 56789*********9875 PP

  == domain 6  score: 4.9 bits;  conditional E-value: 0.006
                 --S-.EEE--SS-- CS
       LRR_8  48 LpsLrsLdLsgNrL 61 
                 +p+L+sLd s+N+L
  EFC36820.1 275 FPNLTSLDASHNNL 288
                 57777777777776 PP

  == domain 7  score: 9.0 bits;  conditional E-value: 0.00031
                 TT-SEEE-TTS--SEE-T.TSSTT.-TT--EEE--SS--- CS
       LRR_8   1 pnLtsLdLsnNrltsldd.eaFkg.lsnLkvLdLsnNllt 38 
                 pnLt+L+L++  + + +  + F+g  ++L +Ld s+N+ t
  EFC36820.1 298 PNLTNLNLTCCGIDDTEIiQLFSGiAPKLAILDVSENEVT 337
                 79**************972567779************876 PP

  == domain 8  score: 2.3 bits;  conditional E-value: 0.039
                 -TT--EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNll 37 
                 l+nL+ ++ s N++
  EFC36820.1 381 LENLTQINFSGNQI 394
                 56666666666665 PP

  == domain 9  score: 6.5 bits;  conditional E-value: 0.002
                 T-TT--EEE--SS---GGGGGGGTT- CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgL 48 
                 +l nLkvL+L + ++t  s + f+  
  EFC36820.1 406 SLVNLKVLKLCRTNITESSFREFMKS 431
                 6889************9988888765 PP

  == domain 10  score: -3.7 bits;  conditional E-value: 3
                 EE-TTSSTT-TT-- CS
       LRR_8  15 slddeaFkglsnLk 28 
                 s++ +aF  l++L+
  EFC36820.1 451 SVCRKAFPYLKRLN 464
                 67888888888875 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1         2   7.1e+03       3      10 ..     102     109 ..     102     110 .. 0.85
   2 ?    4.5   0.2     0.012        42       4      18 ..     127     142 ..     124     148 .. 0.87
   3 !    7.4   0.9    0.0015       5.3       3      17 ..     151     165 ..     149     166 .. 0.89
   4 !   10.2   0.0   0.00018      0.64       3      16 ..     177     190 ..     175     192 .. 0.86
   5 ?    0.4   0.1      0.25     9e+02       3      11 ..     201     209 ..     199     210 .. 0.83
   6 ?    0.7   0.1      0.21   7.5e+02       2      10 ..     225     233 ..     224     235 .. 0.84
   7 !   11.9   0.2   5.2e-05      0.19       2      18 ..     248     264 ..     247     264 .. 0.91
   8 ?    2.5   0.2     0.055     2e+02       3      15 ..     276     288 ..     276     289 .. 0.89
   9 !   11.0   0.8    0.0001      0.37       3      17 ..     298     312 ..     296     313 .. 0.91
  10 !   12.6   0.0   3.1e-05      0.11       4      24 .]     325     345 ..     323     345 .. 0.89
  11 !    6.1   0.0    0.0037        13       4      23 ..     383     402 ..     380     403 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2
       LRR_6   3 thLteLdL 10 
                 t+Lt+L++
  EFC36820.1 102 TKLTSLHI 109
                 689***97 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.012
       LRR_6   4 hLteLdLsgNd.IgDe 18 
                  Lt+L+L+ N  I+++
  EFC36820.1 127 QLTSLSLRNNSqITND 142
                 59********999987 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0015
       LRR_6   3 thLteLdLsgNdIgD 17 
                  hLt L+Lsg +I++
  EFC36820.1 151 KHLTRLNLSGLHISN 165
                 6***********987 PP

  == domain 4  score: 10.2 bits;  conditional E-value: 0.00018
       LRR_6   3 thLteLdLsgNdIg 16 
                 t L++L+Ls+++I 
  EFC36820.1 177 TGLKSLNLSCCNIE 190
                 569*********96 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.25
       LRR_6   3 thLteLdLs 11 
                 ++L++L+L 
  EFC36820.1 201 STLESLNLE 209
                 89*****95 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.21
       LRR_6   2 nthLteLdL 10 
                  ++Lt+L+L
  EFC36820.1 225 MPSLTYLNL 233
                 589*****9 PP

  == domain 7  score: 11.9 bits;  conditional E-value: 5.2e-05
       LRR_6   2 nthLteLdLsgNdIgDe 18 
                  t+L++L++s ++I+D+
  EFC36820.1 248 LTSLRTLNMSNCGISDK 264
                 589************95 PP

  == domain 8  score: 2.5 bits;  conditional E-value: 0.055
       LRR_6   3 thLteLdLsgNdI 15 
                 ++Lt+Ld s+N++
  EFC36820.1 276 PNLTSLDASHNNL 288
                 58*********98 PP

  == domain 9  score: 11.0 bits;  conditional E-value: 0.0001
       LRR_6   3 thLteLdLsgNdIgD 17 
                 ++Lt L+L++++I+D
  EFC36820.1 298 PNLTNLNLTCCGIDD 312
                 79************9 PP

  == domain 10  score: 12.6 bits;  conditional E-value: 3.1e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L  Ld+s N+++D+G++ ++
  EFC36820.1 325 KLAILDVSENEVTDDGISTIS 345
                 7889*************9875 PP

  == domain 11  score: 6.1 bits;  conditional E-value: 0.0037
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt  + sgN+I  +G+  L
  EFC36820.1 383 NLTQINFSGNQIYAKGLLYL 402
                 89**********99999876 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.2     0.001       3.7     102     142 ..     115     153 ..      76     166 .. 0.73
   2 ?    5.2   0.2    0.0036        13      56     146 ..     193     282 ..     178     290 .. 0.75
   3 ?    5.0   0.2    0.0043        15      49     147 ..     336     442 ..     313     458 .. 0.69
   4 ?   -1.4   0.0      0.41   1.5e+03      58      69 ..     455     466 ..     438     468 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.001
       LRR_9 102 eladldPlaslkklellsllknpvtnkkeyrlyviyklkql 142
                  l dl+ + slk+l++lsl +n+ ++++ y +  i  lk+l
  EFC36820.1 115 GLKDLEEVCSLKQLTSLSLRNNSQITNDIYTN--IAELKHL 153
                 37899999999*******99999888888865..4455555 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0036
       LRR_9  56 kldgfPllkrlktlllnnnrivriaeglee.vlPnleelvltnne.lqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                 +l+ +  l  l++l l+    + + e +++  +P+l+ l l n    ++l+d   + +l +l++l + ++ +++k  + l  ++ +++l+ ld
  EFC36820.1 193 QLNLIGTLSTLESLNLEGYTNLSTLESIDKwNMPSLTYLNLENRPfSKSLGD---VCKLTSLRTLNMSNCGISDKMSWELISLNLFPNLTSLD 282
                 5556666777777777777777777888773589999999999883567888...56777778888889999999999888888888888777 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0043
       LRR_9  49 lsdndirkldgfPllkrlktl.llnnnrivriaeglee......vlPnleelvltnnelqeladl.dPlaslkklellsllknpvtnkkeyrlyviy.k 138
                 ++d+ i  +   P+   l+++ +++ n i  i++   +      +l nl+++ +++n++   + l     sl +l++l l ++ +t+ + +r+++    
  EFC36820.1 336 VTDDGISTISTSPYASSLRSItYVSTNNIFVITDLSMKfisnspYLENLTQINFSGNQIYAKGLLyLSQSSLVNLKVLKLCRTNITE-SSFREFMKSgN 433
                 567778889999999999876368888888887644431111114556777788889986655441345678889999888888765.56888875425 PP

       LRR_9 139 lkqlrlldf 147
                 +k+l  +df
  EFC36820.1 434 MKRLCEIDF 442
                 666666666 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 0.41
       LRR_9  58 dgfPllkrlktl 69 
                   fP+lkrl+ +
  EFC36820.1 455 KAFPYLKRLNRV 466
                 47******9865 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   1.0      0.16   5.7e+02       1      11 [.     127     137 ..     103     143 .. 0.82
   2 ?    0.9   0.2      0.31   1.1e+03       1      11 [.     152     162 ..     152     171 .. 0.73
   3 ?    5.7   0.3    0.0086        31       2      13 ..     179     190 ..     178     201 .. 0.79
   4 ?    0.1   0.1      0.59   2.1e+03       2       9 ..     203     210 ..     202     220 .. 0.82
   5 ?    1.9   0.1      0.15   5.2e+02       1      12 [.     227     238 ..     227     248 .. 0.74
   6 ?    8.8   0.1    0.0008       2.9       1      20 [.     250     269 ..     250     273 .. 0.84
   7 ?    5.0   0.3     0.014        50       1      21 [.     277     294 ..     277     297 .. 0.77
   8 ?    2.6   0.1     0.086   3.1e+02       1      13 [.     299     311 ..     299     324 .. 0.76
   9 ?   -2.2   0.0       3.3   1.2e+04       1      15 [.     325     339 ..     325     345 .. 0.70
  10 ?    1.1   0.2      0.28     1e+03       2      12 ..     384     394 ..     383     430 .. 0.54

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++L L+nn+
  EFC36820.1 127 QLTSLSLRNNS 137
                 48888898887 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.31
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++L+Ls+ +
  EFC36820.1 152 HLTRLNLSGLH 162
                 58999987644 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0086
       LRR_1   2 LrhLdLsnnpll 13 
                 L++L+Ls ++++
  EFC36820.1 179 LKSLNLSCCNIE 190
                 9********984 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.59
       LRR_1   2 LrhLdLsn 9  
                 L++L+L++
  EFC36820.1 203 LESLNLEG 210
                 9*****75 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.15
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L+L+n p+
  EFC36820.1 227 SLTYLNLENRPF 238
                 699****99877 PP

  == domain 6  score: 8.8 bits;  conditional E-value: 0.0008
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr+L++sn+ ++++ ++ +
  EFC36820.1 250 SLRTLNMSNCGISDKMSWEL 269
                 69*********998887765 PP

  == domain 7  score: 5.0 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++Ld s+n+l   ++++fq
  EFC36820.1 277 NLTSLDASHNNL---SISWFQ 294
                 8**********8...345554 PP

  == domain 8  score: 2.6 bits;  conditional E-value: 0.086
       LRR_1   1 nLrhLdLsnnpll 13 
                 nL+ L+L+ + ++
  EFC36820.1 299 NLTNLNLTCCGID 311
                 89********983 PP

  == domain 9  score: -2.2 bits;  conditional E-value: 3.3
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L  Ld+s n  ++ 
  EFC36820.1 325 KLAILDVSENEVTDD 339
                 57789**99986554 PP

  == domain 10  score: 1.1 bits;  conditional E-value: 0.28
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ ++ s+n++
  EFC36820.1 384 LTQINFSGNQI 394
                 56666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (470 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       411  (0.0229238); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.26s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 3001.38
//
Query:       EFC36821.1  [L=491]
Description: phosphatidylserine synthase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   1.2e-112  376.1  12.9     3e-112  374.8  12.9    1.7  1  PSS           Phosphatidyl serine synthase
  ------ inclusion threshold ------
      0.057   12.9   0.4       0.15   11.5   0.0    1.9  2  E1-E2_ATPase  E1-E2 ATPase
        5.3    5.2   8.9        2.4    6.4   4.0    2.1  2  DUF2070       Predicted membrane protein (DUF2070)


Domain annotation for each model (and alignments):
>> PSS  Phosphatidyl serine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  374.8  12.9  5.1e-116    3e-112       1     272 [.     108     388 ..     108     389 .. 0.99

  Alignments for each domain:
  == domain 1  score: 374.8 bits;  conditional E-value: 5.1e-116
         PSS   1 PhpavWrvvlglsvlYllllvfllfqdledarqllklldpelgkklpeksyaedCsll.......slenvlekl.dvfvlaHflGwlvkalilRdllll 91 
                 Phpa+Wr+++g+ ++Yll+lvfl+fq+++darq++k+ldp+lg++lpe++ya++C+++        ++nv++++ d f+laH+lG+++kal++Rdl+l+
  EFC36821.1 108 PHPAFWRLITGIGIVYLLFLVFLMFQTKDDARQFMKYLDPSLGQPLPERDYANSCAIYtpddpisYFKNVYDTVyDEFILAHILGYIAKALLFRDLKLC 206
                 9***************************************************************99********************************* PP

         PSS  92 wilsilfEllElslqhllpnFaECWWDhlilDvllcNllGivlGllllkllelkeYk.WegikkikslkkklkrvlkqftpaswteyeWkktkslkrfl 189
                 w+ls++fE++E+++qh+lpnF+ECWWDh++lDvl+cN lGi++Gl+++++l++++Y  W g++ki+++++k+kr+++qftp +wt+y+W+ + ++k+fl
  EFC36821.1 207 WCLSLFFEIMEITFQHWLPNFKECWWDHIVLDVLICNNLGIIIGLWICDYLKMRKYPlWIGVTKIDTTSGKIKRIVQQFTPFNWTSYNWHIFDDAKHFL 305
                 ********************************************************66***************************************** PP

         PSS 190 avllllvvvllleLnvFflkavlelppshllvllRllllallaaaavrelyeyvtdkkvkrlGqqawlllaivvtElllvvkf 272
                  ++l+++++++++Ln+Fflk+vl++pp + l+++Rll++++l+++a+re+y++++d+++kr+G+++w+++ i++tE+l+++kf
  EFC36821.1 306 YFCLIILAMNIVDLNAFFLKYVLWVPPPNKLNIYRLLIWFCLGMPAIREYYQFISDPNTKRIGANTWIAIGIIFTEILVYFKF 388
                 **********************************************************************************9 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   2.6e-05      0.15     100     159 ..      30      96 ..      17     102 .. 0.82
   2 ?   -3.3   0.1      0.92   5.5e+03     122     143 ..     116     137 ..     112     145 .. 0.52

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.6e-05
                   TS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTT.......HHHHHHHHHHHHHS CS
  E1-E2_ATPase 100 lveeakskktplqkkldklgkvlvpvvlliallvflialllgksla.......eallralallvaai 159
                   + + ++ +ktp ++++d + k  ++++l+++++v+++  +++++++       + ++ +++l+++ +
    EFC36821.1  30 ADNLPSGEKTPKEEFIDAFYKPHTITILVASFAVMFYYSFIRHDAIsteqnvkRGIMGMVGLFLVYC 96 
                   444556899***********************************99999888888888888877766 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.92
                   HHHHHHHHHHHHHHS-STTTSS CS
  E1-E2_ATPase 122 lvpvvlliallvflialllgks 143
                   ++ ++++ +l+++++++ ++++
    EFC36821.1 116 ITGIGIVYLLFLVFLMFQTKDD 137
                   4445555555555555544444 PP

>> DUF2070  Predicted membrane protein (DUF2070)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.2     0.015        92     103     147 ..      56     100 ..      30     153 .. 0.44
   2 ?    6.4   4.0   0.00039       2.4       3      89 ..     354     455 ..     352     489 .. 0.65

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.015
     DUF2070 103 alvlslalvfalrllvlvavsdesllkavlpaliqpllailllvl 147
                  lv s+a++f ++++   a+s e+  k  ++ ++ ++l++ +++l
  EFC36821.1  56 ILVASFAVMFYYSFIRHDAISTEQNVKRGIMGMVGLFLVYCVVQL 100
                 222222222222222222222222222222222222222222222 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.00039
     DUF2070   3 klskyifr..lPswkvsllliillalligllaflssk..............lfgillfglpalvaflltlpvlrilggr.....ltykrslflalltel 80 
                 +++++i      ++   ++++i +++   l++f +s+              +  +++f++p +++f++++  +r+++++     + ++  l+l+++ ++
  EFC36821.1 354 EYYQFISDpnTKRIGANTWIAIGIIFTEILVYFKFSEgyylipfpphiwvnWLLFFFFFVPWFISFFFLT--DRSIRKKypvlkFVLNATLTLSIIPLI 450
                 567777764444555666777777777666666666699**********************999998884..444555534444444444444444444 PP

     DUF2070  81 ivviislla 89 
                 ++++    +
  EFC36821.1 451 FMFL----S 455
                 4444....3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       767  (0.0427799); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 3216.46
//
Query:       EFC36822.1  [L=1040]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.034   14.2   0.1       0.12   12.5   0.1    1.9  1  DUF826    Protein of unknown function (DUF826)
      0.079   12.8   3.8        2.5    8.0   0.0    4.2  4  IF2_N     Translation initiation factor IF-2, N-terminal regi
      0.081   12.7   3.1       0.05   13.4   0.5    1.9  2  CLP1_P    mRNA cleavage and polyadenylation factor CLP1 P-loo


Domain annotation for each model (and alignments):
>> DUF826  Protein of unknown function (DUF826)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1     2e-05      0.12      12      50 ..     591     630 ..     586     643 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2e-05
      DUF826  12 lVKeaLrSeeVrkalKaklrkdlesqi.DaeVDavLaeLl 50 
                 ++K +L+Se+  + +K+ + ++l  ++ D +VD+ +  L+
  EFC36822.1 591 IIKSVLLSEKMPESIKNMITENLKKRVgDIKVDELIHSLI 630
                 79************************9999*****99998 PP

>> IF2_N  Translation initiation factor IF-2, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.1      0.17     1e+03      14      32 ..     244     261 ..     241     265 .. 0.82
   2 ?   -3.4   0.1       1.5   8.7e+03      17      29 ..     434     444 ..     432     446 .. 0.78
   3 ?    2.2   0.0     0.028   1.7e+02      13      28 ..     505     519 ..     503     563 .. 0.87
   4 ?    8.0   0.0   0.00042       2.5       4      26 ..     658     680 ..     656     691 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.17
       IF2_N  14 gvkskevikkLfkelGiev 32 
                 ++k+++vi+k+ +e+ +++
  EFC36822.1 244 KKKVTQVIQKF-SEKDFKK 261
                 6899*******.7798885 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.5
       IF2_N  17 skevikkLfkelG 29 
                 sk ++++L+k  G
  EFC36822.1 434 SKVLMTELMK--G 444
                 899*****65..5 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.028
       IF2_N  13 LgvkskevikkLfkel 28 
                 ++++ kev+++L k+l
  EFC36822.1 505 IKKPTKEVVTFL-KQL 519
                 6899********.645 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.00042
       IF2_N   4 irVyeLAkeLgvkskevikkLfk 26 
                 ++V+++A  L++ + ++ik + k
  EFC36822.1 658 TSVQQFASLLKKNPSDLIKNAIK 680
                 89*****************9876 PP

>> CLP1_P  mRNA cleavage and polyadenylation factor CLP1 P-loop
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.5   8.4e-06      0.05      82     175 ..     349     434 ..     321     442 .. 0.80
   2 ?   -2.7   0.1      0.72   4.3e+03     168     187 ..     724     743 ..     673     744 .. 0.51

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 8.4e-06
      CLP1_P  82 alvkelareveekleenkkakasgliIntpGwvkglgaellleliealepdvvvvldqeellnelkrdlp.lskvkvvklpkspgvvqrsreerr 175
                 +++++ +++++     + ++k +++iI t G+ k+  ++ ++ + ++++p+++      +ll+++k+d++ +s v+ +kl+k+ + v++s+ +++
  EFC36822.1 349 KIISKFFNVAK----GSVAVKPQFIIIKTFGMTKQDRKDAKKMISKTFKPKNLK-----KLLSSVKKDFKdVSPVTNKKLSKVAQYVSKSPVKAS 434
                 45555555555....556789*****************************9874.....566667777776677999999999999988877665 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.72
      CLP1_P 168 qrsreerrelreerireYFy 187
                 + + +++ e   e+i++YF+
  EFC36822.1 724 ESNAKSKVEQVAEKIKSYFE 743
                 33445555666777888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1040 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1869  (0.104245); expected 358.6 (0.02)
Passed bias filter:                      559  (0.0311785); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.87u 0.32s 00:00:01.19 Elapsed: 00:00:00.54
# Mc/sec: 5820.43
//
Query:       EFC36823.1  [L=1123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00038   21.1   0.0     0.0024   18.5   0.0    2.5  1  ARID      ARID/BRIGHT DNA binding domain


Domain annotation for each model (and alignments):
>> ARID  ARID/BRIGHT DNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   1.4e-07    0.0024       9      65 ..     305     372 ..     297     381 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.4e-07
                 HHHHHHHTTS.S.SS--......--S...SSS-STTHHHHHHTTTSSHHHHTT.CHHHHHHHHHTS-. CS
        ARID   9 Lkqfhenrgt.l.kkiP......vig...gkevdlykLyraVikrGGfrkvtqknkWeevaqklglpr 65 
                 Lk+f ++++  l + iP       i+   ++e+dl ++  +V k GG+  v+++ kW+eva+ l++++
  EFC36823.1 305 LKSFENQQKHsLnTDIPtilkylYIDhylNNEMDLQQICDMVDKVGGSLLVEKEGKWQEVARTLKITQ 372
                 667777666665777885544442333449*********************999**********9964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1388  (0.0774165); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.84u 0.33s 00:00:01.17 Elapsed: 00:00:00.55
# Mc/sec: 6121.29
//
Query:       EFC36824.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.053   13.7   0.1       0.12   12.5   0.1    1.6  1  IL8       Small cytokines (intecrine/chemokine), interleukin-


Domain annotation for each model (and alignments):
>> IL8  Small cytokines (intecrine/chemokine), interleukin-8 like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   6.7e-06      0.12      25      58 ..     118     154 ..     109     156 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 6.7e-06
                 CSTTSSS-EEEEEET...TSSCEEEETTSHHHHHHHH CS
         IL8  25 tsssCpkpavifttk...kgkevCadpkekwVqklik 58 
                   s+C+++++i++ k   k k  C   +++ Vq+++k
  EFC36824.1 118 DRSECNNNEIILVWKvlkKLKASCELAQNHSVQDVMK 154
                 5799********9988757778**************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       738  (0.0411624); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1835.21
//
Query:       EFC36825.1  [L=450]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.4e-08   32.6   0.1    1.9e-07   31.4   0.1    1.6  1  MACPF     MAC/Perforin domain
  ------ inclusion threshold ------
       0.13   12.8   0.1       0.39   11.2   0.1    1.8  1  PerB      PerB protein


Domain annotation for each model (and alignments):
>> MACPF  MAC/Perforin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   0.1   2.2e-11   1.9e-07      23     209 .]     110     274 ..     106     274 .. 0.84

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 2.2e-11
                 EEEEEEEEEEEEEEES--....B-HHHHHHHHTS-SS--SSTHHH.HHHHHHHH-SEEEEEEEEEEEEEEEEEEEHHHHHHTT--HHHHHHHHHHHHTS CS
       MACPF  23 liiskskcslyqftlkrsnklklseeFlkalneLpsnydsaaedtpyieffekYGTHvitsvtlGGkivyvlkldkeeveklkkkkedclsasagasin 121
                 l+i  s+ + ++  + ++ ++ +++eF++ +  Lp+++d ++    y  ++ ++G  ++ts+++GG ++ ++ ++++    ++++ ++   ++++ s  
  EFC36825.1 110 LYIVDSQKQFFTHSV-NAPDIRVTDEFQQIIDILPEQMDWDM----YNLVLTSFGDSIATSIKYGGIVDMTVSIRSCFNDPQMMQYIS---QELQYS-- 198
                 677777778888888.5669*******************999....****************************99987766666666...676544.. PP

                 -SHHHHHHHHHHHHTT-SS-HHHH---EEEEEESS-GGG----HHHHHHHHHHTTTS-EEEEEEEEEGGGGS-TT-HHHHHHHHHHHH CS
       MACPF 122 gkvslkgkkknssetkekksssqesessktlviGGepeseddksktyseWaesvkenpmpIklelvPisellkeeekkeslkkaleeY 209
                     ++g++++s+  +    +  +++ s++++ GG+p    + s ++ +   +   np+p++le  Pi   +++ +k+ ++kk +e Y
  EFC36825.1 199 ----IDGSSDVSKLPNG---YVRYHKVSQLDIVGGNP----QIS-NIHQRTATFAMNPVPVRLETIPIWRAFPDGPKQANMKKVYESY 274
                 ....4676666655544...4456799*********9....555.6666699********************************9998 PP

>> PerB  PerB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   4.4e-05      0.39      60      91 ..      95     126 ..      55     137 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4.4e-05
        PerB  60 tkhcelffsdhitgeqdviysqsaffshvinh 91 
                     +l+fs +  ge  ++ sq+ ff+h +n 
  EFC36825.1  95 NAGIDLIFSKYFEGELYIVDSQKQFFTHSVNA 126
                 44679***********************9995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (450 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       562  (0.0313459); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2774.51
//
Query:       EFC36826.1  [L=391]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.2e-10   38.9   0.2    1.5e-09   37.7   0.1    1.6  2  ADH_N         Alcohol dehydrogenase GroES-like domain
    1.1e-09   39.4   0.0    2.7e-09   38.2   0.0    1.7  1  ADH_zinc_N_2  Zinc-binding dehydrogenase
      2e-06   27.8   0.0    4.1e-06   26.8   0.0    1.6  1  ADH_zinc_N    Zinc-binding dehydrogenase
     0.0011   18.9   0.0     0.0054   16.5   0.0    1.9  2  DUF2855       Protein of unknown function (DUF2855)


Domain annotation for each model (and alignments):
>> ADH_N  Alcohol dehydrogenase GroES-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.7   0.1   3.4e-13   1.5e-09       2      61 ..      29      90 ..      28     100 .. 0.93
   2 ?   -2.8   0.0       1.3   5.8e+03      92     107 ..      98     113 ..      91     113 .. 0.84

  Alignments for each domain:
  == domain 1  score: 37.7 bits;  conditional E-value: 3.4e-13
                TEEEEEEEEEEE-HHHHHHHTTS..TTTTSSSSEE---EEEEEEEEESTT-CS--TT-EEEE CS
       ADH_N  2 gevlikvkaagiCgsDlhilkgg..kelevklplilGHEivGeveevgpevkklkvGdrVvv 61
                ++v++++k+a++++ D+ + +g   + +++++p+ilG E +G+ve vg++v++++vGd+Vv 
  EFC36826.1 29 DQVMVRLKSASMNRGDYTMRSGAakSFISMQFPCILGKEGSGVVERVGEKVNSIQVGDEVVG 90
                79*******************9976778999*****************************96 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.3
                 -SSSBSEEEECGGGEE CS
       ADH_N  92 dGgfaeyvvvpekklv 107
                  G++ae  v++ek++v
  EFC36826.1  98 TGAYAEFAVFKEKEVV 113
                 799*****99998875 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2   0.0   6.1e-13   2.7e-09       1     133 []     220     389 ..     220     389 .. 0.80

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 6.1e-13
                   TT-SEEEETTSTTHH....................HHH-TT-EEEEEES-HHHHH.HHHHHHE...EEEEE.E..EE----..............S- CS
  ADH_zinc_N_2   1 lGAdevidyrtedfe....................aatggegvDvvldtvggealleaslkvl...pggGr.l..vsiggpp.............ls 58 
                   lGAd vidy++++++                    ++ + + vD v d+vgg ++++++ ++l    + Gr    v i+ pp             ++
    EFC36826.1 220 LGADGVIDYTKTSAAfgnntfhsgdeklsifqtlkKDFKIDFVDMVMDCVGGYYYYDDLTRHLkccTDDGRrTyhVAIA-PPgplelsystvpaiVW 315
                   8*********999999***************99976666699*********9999899988888876668854355555.55689**********66 PP

                   EEE-CHHHCTTT-EEEE--GGG...-.-HHHHHHHHHHHHHHH----EEE....EEEGGGHHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  59 aallkpakkrkgrsvkyeflfsmkasaqadileelaalieeGklrpvvdr....vfpleeaaeAhrylesgrarGKiVl 133
                     l  + k +++++  y f+fs++++ +     +++++++++++ p  ++    +f+le+ ++A ++++s r++GKiV+
    EFC36826.1 316 YILKNKFKSWWSAQNPYYFFFSTSPD-NP----RIMKFLASEQFSPIFEKipitSFSLEDYQKADDLMASQRTVGKIVI 389
                   66666667799**********86666.55....57777777775554442222179**********************7 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.8   0.0   9.1e-10   4.1e-06       1      85 [.     183     291 ..     183     330 .. 0.84

  Alignments for each domain:
  == domain 1  score: 26.8 bits;  conditional E-value: 9.1e-10
                 HHHHHHHHHHHHTT-.....EEEEEESSHHHHHHHHH.TTESEEEET...............TTC.HHHHHHHHHTTTSSEEEEEESSC...SHHHHHH CS
  ADH_zinc_N   1 gvGlaavqlAkalGa.....eviavdsseeklelakk.lGadeviny...............kea.dlverikeltggegvdvvfecvG...sgatlea 74 
                 g G +av +Ak +       +viav+s ++   +a++ lGad vi+y               +e+ ++ + +k+ ++ + vd v++cvG   + + l++
  EFC36826.1 183 GTGCMAVLFAKNFLSryfntKVIAVCSERN-STFAREqLGADGVIDYtktsaafgnntfhsgDEKlSIFQTLKKDFKIDFVDMVMDCVGgyyYYDDLTR 280
                 7899*******9887788889999998886.6888887*********99999999999888866667889999999999**********7777789999 PP

                 HHHCEEEEEEE CS
  ADH_zinc_N  75 alkllkpgGrl 85 
                  lk+++ +Gr 
  EFC36826.1 281 HLKCCTDDGRR 291
                 99999999985 PP

>> DUF2855  Protein of unknown function (DUF2855)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   1.2e-06    0.0054     142     206 ..     170     233 ..     132     297 .. 0.77
   2 ?   -0.2   0.0      0.14   6.5e+02      94     143 ..     330     380 ..     316     389 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1.2e-06
     DUF2855 142 sgakvvvllsASsKTAlslayllrkrrkaeegplklvglTSaknrafveslglydkvvsYddles 206
                 +++ ++v+++ASs T+ ++a l++k+  ++  ++k++++ S++n++f ++    d v++Y++ + 
  EFC36826.1 170 KKSLTIVVIGASSGTG-CMAVLFAKNFLSRYFNTKVIAVCSERNSTFAREQLGADGVIDYTKTSA 233
                 334489*********9.7888888888888778***************************98765 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.14
     DUF2855  94 mpiYnrylrvsedpay.esdeeealtallrplfetsflledflfddadlsg 143
                 +p+Y  +++ +++p++ +   +e+   ++  + +tsf led+ ++d+ + +
  EFC36826.1 330 NPYYFFFSTSPDNPRImKFLASEQFSPIFEKIPITSFSLEDYQKADDLMAS 380
                 5666666777777777777778888888999999********999876554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       455  (0.0253779); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2424.30
//
Query:       EFC36827.1  [L=834]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-31  110.1   0.9    1.9e-31  109.4   0.9    1.3  1  Pkinase         Protein kinase domain
    3.8e-18   65.7   0.1    7.7e-18   64.7   0.1    1.5  1  Pkinase_Tyr     Protein tyrosine kinase
    7.1e-17   61.8   0.6    1.8e-08   34.8   0.2    2.5  2  Ank_2           Ankyrin repeats (3 copies)
    1.2e-13   50.9   1.6    0.00077   19.7   0.0    3.8  3  Ank_5           Ankyrin repeats (many copies)
    1.8e-13   49.3   2.5      0.046   14.3   0.0    6.5  6  Ank_3           Ankyrin repeat
    4.6e-08   33.4   0.2      0.078   13.6   0.0    4.1  5  Ank_4           Ankyrin repeats (many copies)
    6.6e-06   26.3   0.0       0.94   10.0   0.0    4.1  3  Ank             Ankyrin repeat
    0.00081   18.3   0.0     0.0017   17.2   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase
     0.0021   17.5   0.1     0.0064   15.9   0.0    1.7  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.013   14.8   0.0      0.032   13.6   0.0    1.6  1  Kinase-like     Kinase-like
       0.12   11.9   0.0       0.23   11.0   0.0    1.4  1  DHBP_synthase   3,4-dihydroxy-2-butanone 4-phosphate synthase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.4   0.9   1.2e-34   1.9e-31       1     260 [.     544     828 ..     544     830 .. 0.85

  Alignments for each domain:
  == domain 1  score: 109.4 bits;  conditional E-value: 1.2e-34
                 EEEEEEEEEESSEEEEEEEETTTTE....EEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE................SSEEEEEEE- CS
     Pkinase   1 yekleklGeGsfGkVykaveketgk....ivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee................kdelylvley 79 
                 y+k++ lG+G++G Vyka++ ++gk     +AvK ++  +++  ++   l+    l kl+ ++i+ + +v                   k++l++ ++y
  EFC36827.1 544 YRKMQLLGKGTNGYVYKAKKFNRGKddppVIAVKLVDFFSTEALNK--SLKSAMNLIKLRQDHIIGVRDVAVLkckipennqnsndltnKSTLCVEMDY 640
                 78999*************9977766333369****99988888765..5666666778999********9988899************9999******* PP

                 -TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET...TTE...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH... CS
     Pkinase  80 veggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide...kge...lKitDFGlakelessskltsfvgtseYlAPEvl... 169
                  ++g+l++l+++k++l+e+ +kk+++qi+  l+y+ +++i+Hr +Kp+NiL+ e   + e     ++ F l+k ++ s +  ++ g+ ++++PE+l   
  EFC36827.1 641 YDKGSLESLIKQKVVLKEAVIKKFISQIIGTLQYMNKHKIVHRNIKPHNILLREwdpS-EnidTVLIGFRLSKSVSDSASDIQQAGSLQFIPPELLdis 738
                 ****************************************************965552.1456999********************************9 PP

                 ....TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT..SHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 170 ....keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..etkeklpeaseiseeakdllkkllkkdpkkRltaeellq 260
                     +++ + +++D+++lGv++y+llt  ++    +g     k      +  k+++   ++   ++++  s  + +l+ ++l+ +  +R+t +e+l+
  EFC36827.1 739 eeleENTAMFASADIFALGVTCYQLLTFDTVTM-INGLI--MKYG----NEEKVMNhlRSSIIKNQHYPYSTGLVELVISMLRLNTADRITLDEILD 828
                 98855566699********************99.44433..2222....234455522224444556666***********************9986 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.7   0.1   4.7e-21   7.7e-18       4     259 .]     547     830 ..     544     830 .. 0.84

  Alignments for each domain:
  == domain 1  score: 64.7 bits;  conditional E-value: 4.7e-21
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE........SSSS..........EEEEEE-- CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct........keep..........llivteyv 83 
                   + lG+G+ G V++++  ++ +++   +avK ++  +te   ++ l+ a  + kl++++i+ +  v +        +  +          l++ ++y 
   EFC36827.1 547 MQLLGKGTNGYVYKAKKFNRGKDDPPVIAVKLVDFFSTEA-LNKSLKSAMNLIKLRQDHIIGVRDVAVlkckipenN--QnsndltnkstLCVEMDYY 641
                  578***************999999999******7776666.778888888999999999998887766556676541..146677888879999**** PP

                  TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHH CS
  Pkinase_Tyr  84 kgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEs 176
                  ++G+L++ +++k    l+   + +f+ q+   ++y++++k+vHr++   N+Ll+e     n    +  f L++++   ++  ++ ++  ++++++pE 
   EFC36827.1 642 DKGSLESLIKQK--VVLKEAVIKKFISQIIGTLQYMNKHKIVHRNIKPHNILLREwdpseNIDTVLIGFRLSKSV---SDSASDIQQAGSLQFIPPEL 734
                  *********998..999999999*******************************988876444445569999999...55566677778899999999 PP

                  HHHSE.......EEHHHHHHHHHHHHHHHHTTSSGT......TTTS.HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 177 lkekk.......ftsksDvWsfGvllwEiftlgesp......ypgl.kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                  l+ ++       +  ++D+++ Gv+++ ++t+   +      + ++ ++e+v+++l+++   ++    ++ l el+ + ++ + ++R t+ e++++l
   EFC36827.1 735 LDISEeleentaMFASADIFALGVTCYQLLTFDTVTmingliM-KYgNEEKVMNHLRSSIIKNQHYPYSTGLVELVISMLRLNTADRITLDEILDRL 830
                  88777677777788899**************888776777744.444889999999999999999999999******************99998765 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.0   1.4e-08   2.3e-05       3      80 ..     115     202 ..     101     205 .. 0.84
   2 !   34.8   0.2   1.1e-11   1.8e-08      10      83 .]     236     325 ..     227     325 .. 0.77

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 1.4e-08
       Ank_2   3 lAakngnlelvklLl..egadpn..k.ngktaLhyAakngnleivklLleh...ad..ndgrtpLhyAarsghleivklLlekgadin 80 
                  ++++gn+e+v+ ++   +a +n  +  g taL +A+ + n +++k+L+     ++   +gr++L+y+ + + + ++ +L+  ga+++
  EFC36827.1 115 KMVREGNYEMVEAMInnREAGINdcDtSGCTALGVAVDSVNMKMLKFLIRRggnTNgiIYGRSILQYCMERNLIPFASYLIRMGAKPK 202
                 56788999*******5433444453269***********99999*****97766668888*********9999********7799876 PP

  == domain 2  score: 34.8 bits;  conditional E-value: 1.1e-11
       Ank_2  10 lelvklLl.egadpn....k....ngktaLhyAakngnleivklLleh...ad....ndgrtpLhyAarsghleivklLlekgadinlkd 83 
                 +e  ++L+ ++ + n    +    + +t+L++  k++n e+v++L++h   +d    + +++ L++A++++h ++vk L+++ga++ ++d
  EFC36827.1 236 FERANYLItKNLKHNilivDclnqERETPLYVLSKHNNPEAVEWLIKHgaqVDlkvmDRNMNSLQVAIQCKHWNVVKTLIKNGANMYIRD 325
                 55667777644333333331333588*********************99884466767899*******************99***99886 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.2   5.4e-05     0.088      17      53 ..     107     147 ..      93     150 .. 0.80
   2 !   19.7   0.0   4.7e-07   0.00077       9      45 ..     254     290 ..     249     295 .. 0.89
   3 !   15.0   0.0   1.4e-05     0.023      16      51 ..     295     330 ..     292     331 .. 0.94

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 5.4e-05
       Ank_5  17 n...tpLhvAakygaadvvrlLl.argadlnltdsrGltal 53 
                 n   + L   ++ g+ ++v+ ++ +r+a +n +d +G tal
  EFC36827.1 107 NgkiSLLLKMVREGNYEMVEAMInNREAGINDCDTSGCTAL 147
                 3455778889999***************************9 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 4.7e-07
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLlargadlnlt 45 
                 v++l+++++tpL v +k+++++ v++L+++ga  +l+
  EFC36827.1 254 VDCLNQERETPLYVLSKHNNPEAVEWLIKHGAQVDLK 290
                 567888888********************99998876 PP

  == domain 3  score: 15.0 bits;  conditional E-value: 1.4e-05
       Ank_5  16 gntpLhvAakygaadvvrlLlargadlnltdsrGlt 51 
                  ++ L vA+ + +++vv+ L+++ga+  ++d+ Glt
  EFC36827.1 295 NMNSLQVAIQCKHWNVVKTLIKNGANMYIRDEFGLT 330
                 579999****************************98 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0025       4.1       4      30 ..     111     137 ..     109     138 .. 0.92
   2 !   10.0   0.0    0.0007       1.1       2      30 ..     143     170 ..     142     171 .. 0.91
   3 ?    5.6   0.0     0.019        31       1      29 [.     174     201 ..     174     203 .. 0.93
   4 ?   -1.7   0.0       4.6   7.5e+03       8      23 ..     229     244 ..     226     250 .. 0.84
   5 !   14.3   0.0   2.8e-05     0.046       3      30 ..     262     288 ..     260     289 .. 0.92
   6 ?    4.8   0.0     0.033        54       3      28 ..     296     320 ..     294     323 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0025
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 ++L   +r gn+e+v+++++n+ a +n
  EFC36827.1 111 SLLLKMVREGNYEMVEAMINNREAGIN 137
                 79999***************9999888 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.0007
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 G+t+L +A+ s n +++kfL++ +g + n
  EFC36827.1 143 GCTALGVAVDSVNMKMLKFLIR-RGGNTN 170
                 99********************.887765 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.019
       Ank_3   1 nGetpLhlAarsgnleivkfLlenkgadv 29 
                 +G+++L ++++ + ++ + +L++ +ga +
  EFC36827.1 174 YGRSILQYCMERNLIPFASYLIR-MGAKP 201
                 79*********************.99976 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 4.6
       Ank_3   8 lAarsgnleivkfLle 23 
                  A+r  n+e++ +L+ 
  EFC36827.1 229 NALRIRNFERANYLIT 244
                 5899999*******98 PP

  == domain 5  score: 14.3 bits;  conditional E-value: 2.8e-05
       Ank_3   3 etpLhlAarsgnleivkfLlenkgadvn 30 
                 etpL++  +++n+e v++L++ +ga v+
  EFC36827.1 262 ETPLYVLSKHNNPEAVEWLIK-HGAQVD 288
                 8********************.899886 PP

  == domain 6  score: 4.8 bits;  conditional E-value: 0.033
       Ank_3   3 etpLhlAarsgnleivkfLlenkgad 28 
                 ++ L +A+ + + ++vk L++ +ga+
  EFC36827.1 296 MNSLQVAIQCKHWNVVKTLIK-NGAN 320
                 567999***************.8987 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0    0.0001      0.16       9      55 .]     117     163 ..     111     163 .. 0.88
   2 ?   -1.5   0.0       2.6   4.3e+03      39      55 .]     227     243 ..     227     243 .. 0.91
   3 !    9.1   0.0    0.0013       2.1      27      55 .]     254     281 ..     235     281 .. 0.70
   4 !   13.6   0.0   4.8e-05     0.078       3      55 .]     263     315 ..     261     315 .. 0.91
   5 ?    5.2   0.0     0.021        34      15      38 ..     309     331 ..     295     335 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.0001
       Ank_4   9 aisgrlelvrlLlekg.adinaqdnrsGetalhiAakrgnveilklLl 55 
                 + +g++e+v+  ++++ a in + + sG tal  A+   n ++lk+L+
  EFC36827.1 117 VREGNYEMVEAMINNReAGINDC-DTSGCTALGVAVDSVNMKMLKFLI 163
                 4589*********996477***9.9*********************98 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 2.6
       Ank_4  39 lhiAakrgnveilklLl 55 
                 +++A+++ n+e++ +L+
  EFC36827.1 227 FINALRIRNFERANYLI 243
                 679************98 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.0013
       Ank_4  27 inaqdnrsGetalhiAakrgnveilklLl 55 
                 +++  n + et+l+   k++n+e++++L+
  EFC36827.1 254 VDCL-NQERETPLYVLSKHNNPEAVEWLI 281
                 3333.66677******************8 PP

  == domain 4  score: 13.6 bits;  conditional E-value: 4.8e-05
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklLl 55 
                 t+L  + ++++ e+v++L+ +ga+++    ++ ++ l+ A++  + +++k L+
  EFC36827.1 263 TPLYVLSKHNNPEAVEWLIKHGAQVDLKVMDRNMNSLQVAIQCKHWNVVKTLI 315
                 88999999****************99997788999*****9999999999887 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.021
       Ank_4  15 elvrlLlekgadinaqdnrsGeta 38 
                  +v+ L+ +ga+ + + ++ G+t+
  EFC36827.1 309 NVVKTLIKNGANMYIR-DEFGLTC 331
                 689*************.*****98 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0       0.1   1.7e+02       2      28 ..     143     170 ..     142     171 .. 0.82
   2 !    7.9   0.0    0.0027       4.4       4      29 ..     263     289 ..     261     290 .. 0.88
   3 !   10.0   0.0   0.00058      0.94       8      31 ..     301     325 ..     298     326 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.1
                 SBBHHHHHH...HHTTHHHHHHHH.TTTSTT CS
         Ank   2 GnTPLHlAa...tngkkriiklLL.hGAnln 28 
                 G+T+L +A+   + +   ++k+L+ +G n n
  EFC36827.1 143 GCTALGVAVdsvNMK---MLKFLIrRGGNTN 170
                 9******99887667...******7776766 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0027
                 BHHHHHHHHTTHHHHHHHH.TTTSTTC CS
         Ank   4 TPLHlAatngkkriiklLL.hGAnlna 29 
                 TPL + +  ++++ +++L+ hGA +++
  EFC36827.1 263 TPLYVLSKHNNPEAVEWLIkHGAQVDL 289
                 9***7799999***********98775 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00058
                 HHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   8 lAatngkkriiklLL.hGAnlnald 31 
                 +A+++++++++k L+ +GAn  ++d
  EFC36827.1 301 VAIQCKHWNVVKTLIkNGANMYIRD 325
                 69999**********99***98887 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0     1e-06    0.0017     306     386 ..     658     735 ..     650     744 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1e-06
  Pkinase_fungal 306 kellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievl 386
                     +++++ ++  I g  + ++k +i+Hr i  +Nil+ + +  ++   +Li + l k++sd  s +++ ++ G l+F+  e+l
      EFC36827.1 658 EAVIKKFISQIIGTLQYMNKHKIVHRNIKPHNILLREWDPSENIDTVLIGFRLSKSVSD--S-ASDIQQAGSLQFIPPELL 735
                     5667778888888888899*****************9999999***************6..3.334689999999977766 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.4   2.3e+03      87     114 ..     235     262 ..     221     283 .. 0.75
   2 !   15.9   0.0   3.9e-06    0.0064     103     167 ..     644     709 ..     612     723 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.4
         Kdo  87 gleyrAlllterlegaqdLedllakwae 114
                 ++e+   l+t++l++ + ++d+l++ +e
  EFC36827.1 235 NFERANYLITKNLKHNILIVDCLNQERE 262
                 45577789999***99999999999766 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 3.9e-06
         Kdo 103 qdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqee.eeeaeiwliDld 167
                  +Le l+++  +l+e++ ++ + ++  + + +++ ++ H+ + ++nill++ + +e++  +li + 
  EFC36827.1 644 GSLESLIKQKVVLKEAVIKKFISQIIGTLQYMNKHKIVHRNIKPHNILLREWDpSENIDTVLIGFR 709
                 5899999997779**************************************999999999999875 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0     2e-05     0.032     144     285 ..     660     817 ..     630     820 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2e-05
  Kinase-like 144 iarlllTlqlirlaanLqakglvhgkftvdnlllde.....kgglmlggftaLvragtkvvlseve....kgfaPpEllgsrggytrknktkmthkld 232
                  + ++ +  q+i   +++ ++ +vh +++++n+ll e     +   +l gf  L +       s ++      f PpEll        +++t m  + d
   EFC36827.1 660 VIKKFI-SQIIGTLQYMNKHKIVHRNIKPHNILLREwdpseNIDTVLIGFR-LSKSVSDSA-SDIQqagsLQFIPPELLDISEE--LEENTAMFASAD 752
                  445555.689999*********************86222224556777775.444333333.55554444679******99777..567999999*** PP

  Kinase-like 233 aWqlGlviyriwclk...lPltlateeakeew........kfklck.kipekvkaLlkkfLqlsq 285
                    +lG++ y +  ++   + ++l+ + ++ee         + k  + + +  +  L++ +L+l+ 
   EFC36827.1 753 IFALGVTCYQLLTFDtvtMINGLIMKYGNEEKvmnhlrssIIKNQHyPYSTGLVELVISMLRLNT 817
                  *********99876511134455555555554555555543333333555555556666666555 PP

>> DHBP_synthase  3,4-dihydroxy-2-butanone 4-phosphate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00014      0.23      13      59 ..     251     296 ..     245     325 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00014
                    EEEESSTTTT-BEEEEEEGGG--HHHHHHHHHHB-S--EEEEEHHHH CS
  DHBP_synthase  13 vivvDdedrenegdLiiaAekvtpekvafmirhasGlicvalteera 59 
                    +++vD  ++e+e+ L + +++ +pe+v+++i+h+   + + + ++++
     EFC36827.1 251 ILIVDCLNQERETPLYVLSKHNNPEAVEWLIKHGAQ-VDLKVMDRNM 296
                    89*******************************976.4444444555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (834 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1015  (0.0566122); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.87u 0.36s 00:00:01.23 Elapsed: 00:00:00.55
# Mc/sec: 4538.38
//
Query:       EFC36828.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-47  160.9   0.5    2.3e-47  160.3   0.5    1.2  1  THF_DHG_CYH_C  Tetrahydrofolate dehydrogenase/cyclohydrolase,
    6.7e-38  129.5   0.8    1.3e-37  128.6   0.8    1.5  1  THF_DHG_CYH    Tetrahydrofolate dehydrogenase/cyclohydrolase,
  ------ inclusion threshold ------
      0.023   14.8   0.1      0.047   13.7   0.1    1.5  1  AdoHcyase_NAD  S-adenosyl-L-homocysteine hydrolase, NAD bindi


Domain annotation for each model (and alignments):
>> THF_DHG_CYH_C  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  160.3   0.5   3.9e-51   2.3e-47      14     156 ..     156     310 ..     145     314 .. 0.90

  Alignments for each domain:
  == domain 1  score: 160.3 bits;  conditional E-value: 3.9e-51
                    SS--HHHHHHHHHHHHC....T---TT-EEEEE---TTTHHHHHHHHHCT.T-EEEEE-TTSCCHHHHHCCSSEEEE-SS-TT-B-GGGS-TT-EE CS
  THF_DHG_CYH_C  14 allpctpkgvvellket....gielegkkvvvvGrsnivgkplallLlek.natVtvchsktkdlaeitreadivvvavGkpelikaemvkegavv 104
                     ++pctp g++e++++t    +++leg + vvvG+snivg p al+Ll++ +  V+++h k+++++e++++adi+vv++G +e+ik e++k+ga+v
     EFC36828.1 156 NFVPCTPLGIMEMIRRTaqklNMNLEGLDSVVVGASNIVGIPTALVLLNQlQTSVQLLHIKSQNIPEKISKADILVVCCGCAEIIKPEWIKKGAIV 251
                    69************986222256799******************9999887999****************************************** PP

                    EE---EEC......-TTEEE-SB-HH.HHCTTSSEE--TTTSCHHHHHHHHHHHHHHHH CS
  THF_DHG_CYH_C 105 iDvGinrv......ekgklvGDvdfe.evkevasaitPvpgGVGpmTvamllkntleaa 156
                    iDvG++ v      ++ +lvGDv f+ ++k+ asa tPvpgGVGp+T+a+l+knt++++
     EFC36828.1 252 IDVGLTPVedktqeRGFRLVGDVLFDdNLKKRASAATPVPGGVGPVTIASLMKNTYHSF 310
                    ********9999877889******96368999***********************9876 PP

>> THF_DHG_CYH  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.6   0.8   2.2e-41   1.3e-37       1     116 []      12     134 ..      12     134 .. 0.93

  Alignments for each domain:
  == domain 1  score: 128.6 bits;  conditional E-value: 2.2e-41
                  E--HHHHHHHHHHHHHHHHHHHHH..H...T---EEEEEEES--HHHHHHHHHHHHHHHHTT-EEEEEEE-..TT--HHHHHHHHHHHHH-TT--EEE CS
  THF_DHG_CYH   1 lldGkalakeireelkeeveklke..k...gvkpkLavilvgddpasevYvrnkkkaceevGieseliklp..edvseeellklieelneddsvdGil 91 
                  l++G ++a+ei+ee+k+++e++ e  k    ++p+Lav++vg++++s +Yv+ k++ac+e+Gies + +++  ++v++e+++k+i+++n+dd+v+Gil
   EFC36828.1  12 LINGLEIAAEIKEEIKRDIERIVEkqKggqVRRPGLAVVMVGSRKDSLTYVQRKQEACAELGIESFKTHFEddQSVTDEDVIKTIQQYNADDRVHGIL 109
                  689*****************9887551554669*************************************62266*********************** PP

                  E-SS-STTS-HHHHHCCS-GGGBTT CS
  THF_DHG_CYH  92 vqlPlpkhidekaileaispeKDVD 116
                  vqlPlp+h++e++ile+isp+KDVD
   EFC36828.1 110 VQLPLPSHLNEEKILESISPAKDVD 134
                  ************************9 PP

>> AdoHcyase_NAD  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   7.9e-06     0.047      57     112 ..     203     257 ..     184     266 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 7.9e-06
                    HHHHHHHCTT-EE..--HHHCTTT-SEEEE-SSSSSSB-HHHHCCS-TTEEEEE-SST CS
  AdoHcyase_NAD  57 icalqaameGfev..vtleevvkkadivvtttGnkdiitlehlkkmkddaivcniGhf 112
                    ++ lq++++ +++  +++ e ++kadi+v + G+ +ii+ e +   k+ aiv ++G  
     EFC36828.1 203 LNQLQTSVQLLHIksQNIPEKISKADILVVCCGCAEIIKPEWI---KKGAIVIDVGLT 257
                    566777777666611467899*****************99875...678888888865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       845  (0.0471303); expected 358.6 (0.02)
Passed bias filter:                      704  (0.039266); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.55
# Mc/sec: 1761.12
//
Query:       EFC36829.1  [L=1338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      6e-60  202.8   4.4    3.8e-34  118.2   0.7    2.5  2  Pkinase         Protein kinase domain
    3.1e-41  141.4   1.9    1.8e-27   96.3   0.2    2.3  2  Pkinase_Tyr     Protein tyrosine kinase
     0.0035   16.2   0.0     0.0086   14.9   0.0    1.6  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.032   13.9   0.0      0.078   12.6   0.0    1.6  1  FTA2            Kinetochore Sim4 complex subunit FTA2


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.7   0.2   7.4e-28   3.3e-24      85     264 .]      82     261 ..      73     261 .. 0.80
   2 !  118.2   0.7   8.5e-38   3.8e-34       4     228 ..     416     666 ..     413     734 .. 0.78

  Alignments for each domain:
  == domain 1  score: 85.7 bits;  conditional E-value: 7.4e-28
                 HHHHHHHHSS.--HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH...TTSCB..SH CS
     Pkinase  85 ladllerkgs.lseeeakkiakqilegleylH.skgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl...keney..sk 176
                 l ++ + kg   se+ + k++ q+l+g+ ++H + ++ H  l p+N +++++g++K++D G++   ++   + ++    +Y +P +    k+ e   ++
  EFC36829.1  82 LLNIGNYKGYkPSEKVIAKYIDQVLQGIMFMHqKLKMAHLNLTPNNTMLSRNGQIKLCDIGFVLSRDE---YIKYQPCINYSSPSLFkcnKSCEWtkQA 177
                 5555554444378999****************5568**************************855444...77888889********776444442355 PP

                 HHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 177 kvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                  +D+Ws+G++++el+t++ pf++ + ++     l +l ++ k ++   ++ +p+ +++se+++d+l+ ++k    +R  +++l +hp++
  EFC36829.1 178 LADIWSVGCLVIELMTERRPFYDYDWNS-----LFELLSSGKNMEeMIRKYYPKSESCSESVIDFLNLCFKNHSYTRSLIKNLTHHPWI 261
                 68********************555555.....4443333344442456689999*********************************7 PP

  == domain 2  score: 118.2 bits;  conditional E-value: 8.5e-38
                 EEEEEEESSEEEEEEEE....TTTTEEEEEEEEECHCHCHHHH...HHHHHHHHHHHHHSCTTB--EEEEEEE..............SSEEEEEEE--T CS
     Pkinase   4 leklGeGsfGkVykave....ketgkivAvKkikkekakkkke...kkvlrEikilkklkhpnivrlyevfee..............kdelylvleyve 81 
                 l+k+ +G+f++Vy + +    +++ k+vA+K + ++ + ++++   +++++E   +  ++hpniv++++vf++                 l++v+ y +
  EFC36829.1 416 LRKIQSGGFSSVYLCEDhfgsSSQTKQVALKLLPVDMDHSNSNqsfNDAMKEALQMLMFNHPNIVKVLDVFQHyynpislesdtnsdCAVLCIVMHYYP 514
                 678999*********86233258999*******999998888878999***********************************998777889******* PP

                 TEBHHHHHH..HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET...TTE........EEE-SGTTSEESSSSCSBCTTTSCGGGS-HH CS
     Pkinase  82 ggeladlle..rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide...kge........lKitDFGlakelessskltsfvgtseYlAPE 167
                  g+l +l++  +  +l+ +++ +i++qi+++l  lHsk++iHrD+Kp+NiLi +   + e        + ++DFGl+k++ +s  + s+ gt  + +PE
  EFC36829.1 515 YGDLSSLIRtsDAAILPLKTIISIMQQIFSALVELHSKKVIHRDIKPQNILIGSiekN-ErnqiskvhVLVGDFGLSKHIVESR-AFSVSGTMGFQSPE 611
                 *********7555669************************************954440.25556666699************98.999*********** PP

                 HHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHT.HHHHHHHCTSHH...H CS
     Pkinase 168 vlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq.lekilkilgetkeklp 228
                 +  +++y+ k+DvWs+       l++    s  +  e++++ ++q + ++ +      e  p
  EFC36829.1 612 LQLNQGYGLKADVWSAVPSYHRHLNEVDTISRPTM-ETQQNTMEQnIYSTPQ------ERNP 666
                 ***************98888888887777773333.3333333331222222......2222 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.2   0.1     3e-15   1.4e-11     102     257 ..      95     257 ..      74     258 .. 0.82
   2 !   96.3   0.2   3.9e-31   1.8e-27       5     227 ..     417     666 ..     415     684 .. 0.80

  Alignments for each domain:
  == domain 1  score: 44.2 bits;  conditional E-value: 3e-15
                  HHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.....EEHHHHHHHHHH CS
  Pkinase_Tyr 102 lkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.....ftsksDvWsfGv 193
                   k + +++ qv +G+ ++++k k+ H +l+  N +ls+n ++k++D G   +    dey k    + ++++ +p  +k +k      +  +D+Ws G 
   EFC36829.1  95 EKVIAKYIDQVLQGIMFMHQKlKMAHLNLTPNNTMLSRNGQIKLCDIGFVLSR---DEYIKY---QPCINYSSPSLFKCNKscewtKQALADIWSVGC 186
                  566789999*********99857*************************98776...555543...45788889888877776675445568******* PP

                  HHHHHHTTSSGTTTTSHHHHHHHHHHTTEES........-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 194 llwEiftlgespypglkneevleklkegkrl........ekpekcpeelyelmkkcweedpeeRptfselve 257
                  l++E++t  ++p+ +++ ++++e l++gk++        +k e+c+e++ ++++ c++++   R  +++l++
   EFC36829.1 187 LVIELMT-ERRPFYDYDWNSLFELLSSGKNMeemirkyyPKSESCSESVIDFLNLCFKNHSYTRSLIKNLTH 257
                  *******.899*99*99999999999988862222222256799********************99998865 PP

  == domain 2  score: 96.3 bits;  conditional E-value: 3.9e-31
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH....HHHHHHHHHHHHTS-BTTB--EEEEEE...SSSS.............EEEEEE- CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateee....keelleeakimkklkhpnivkllgvct...keep.............llivtey 82 
                  +k+ +G f++V+ ++ +  +++++ +Va+K l  ++++++     ++ ++ea  m  ++hpnivk+l v     +  p             l+iv+ y
   EFC36829.1 417 RKIQSGGFSSVYLCEDHFGSSSQTKQVALKLLPVDMDHSNsnqsFNDAMKEALQMLMFNHPNIVKVLDVFQhyyN--PislesdtnsdcavLCIVMHY 512
                  6899*************9999**********9654444432112678899*******************995440..25555667889999******* PP

                  -TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE..........TTEEEE-STTTHEETTTSSEEEETTSSTSGGG CS
  Pkinase_Tyr  83 vkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse..........nkvvkisDfGLardiekddeyvkkeeaklpvk 170
                   ++GdL++ +r+++ + l lk+++s+++q+ +++  L+skk++Hrd+  +N+L+ +          + +v ++DfGL+++i ++     + +    + 
   EFC36829.1 513 YPYGDLSSLIRTSDAAILPLKTIISIMQQIFSALVELHSKKVIHRDIKPQNILIGSieknernqisKVHVLVGDFGLSKHIVESR----AFSVSGTMG 606
                  *******************************************************9999999999888999**********4444....445556788 PP

                  GS-HHHHHHSEEEHHHHHHH....HHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BB CS
  Pkinase_Tyr 171 WmapEslkekkftsksDvWs....fGvllwEiftlgespypglkneevleklkegkrlekp 227
                  + +pE   ++ +  k+DvWs    +   l E+ t  ++p  + +++++ +++ +  + ++p
   EFC36829.1 607 FQSPELQLNQGYGLKADVWSavpsYHRHLNEVDT-ISRPTMETQQNTMEQNIYSTPQERNP 666
                  99*****************644447777778777.44455555555555555444443333 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   1.9e-06    0.0086     312     384 ..     539     611 ..     531     627 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.9e-06
  Pkinase_fungal 312 lrDaIkghrsLflkagiLHrDiSenNilitdskke.....gerkglLiDLDlakelsddssesgarertGTleFmaie 384
                     +++   ++ +L+  ++++HrDi  +Nili   +k+     ++ + l+ D+ l k++ +      a    GT+ F + e
      EFC36829.1 539 MQQIFSALVELH-SKKVIHRDIKPQNILIGSIEKNernqiSKVHVLVGDFGLSKHIVES----RAFSVSGTMGFQSPE 611
                     556667888999.9***************955555456667788888999999999963....344568999997755 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.7e-05     0.078     156     208 ..     504     569 ..     461     570 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.7e-05
        FTA2 156 piraIVKel.............ellkeqeelevsqlpkllrdlkklhklgIvvrDlkeenyidgkL 208
                 ++++IV  +             + +  + ++++s+++++ + l +lh+  +++rD+k++n++ g++
  EFC36829.1 504 AVLCIVMHYypygdlsslirtsDAAILPLKTIISIMQQIFSALVELHSKKVIHRDIKPQNILIGSI 569
                 556666666666666665555545555678899***************************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1129  (0.0629706); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.97u 0.31s 00:00:01.28 Elapsed: 00:00:00.52
# Mc/sec: 7742.79
//
Query:       EFC36830.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       714  (0.0398237); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1335.66
//
Query:       EFC36831.1  [L=519]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (519 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 3467.03
//
Query:       EFC36832.1  [L=217]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.6e-50  169.6   0.2    8.6e-50  169.4   0.2    1.0  1  Peptidase_C12  Ubiquitin carboxyl-terminal hydrolase, family 


Domain annotation for each model (and alignments):
>> Peptidase_C12  Ubiquitin carboxyl-terminal hydrolase, family 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.4   0.2   4.8e-54   8.6e-50      11     210 ..       1     196 [.       1     197 [. 0.86

  Alignments for each domain:
  == domain 1  score: 169.4 bits;  conditional E-value: 4.8e-54
                    HHHHHHHHT--S...EEEE--S.SHHHTTS-..--EEEEEEE.----------.---------..T...TS------STTGHHHHHHHHHHHH..S CS
  Peptidase_C12  11 ftelleklGvkg.vqfeevyslddellaslp..vyglillfkyieeeeeeeerekeeeekdeeeeevsekvfFakQtiqnaCgtiAlLhvllNlek 103
                    ++++++klG+ g ++  +v++lddell+++p  v +++llf+ ++e+ ++  ++ke+ee +++++++ +++fF+kQti naCgt+A++h+l+N   
     EFC36832.1   1 MNNYANKLGLGGdYEYCDVFGLDDELLDMVPkpVISVLLLFPLTKEN-QN-LQQKEDEEMEKNQDSIPKELFFMKQTIGNACGTVAIIHSLANN-I 93 
                    799*******************999*****556*********55444.33.3335555666666789999***********************4.5 PP

                    TS--.-TTSHHHHHHHHHTTS-HHHHHHHHHT-HHHHHHHTTSC..---SSTHHHHS--EEEEEEEEETTEEEEE-TTS.S-EEEEE--T..TTHH CS
  Peptidase_C12 104 eaeeielgseLkkfkeftkelspeergealenseeireahnsfasegqteapeeeedvafHFiafvpvngklyeLDGlkegPidlgeveeeeedle 199
                    ++ ++   s L++f++   + s+ee ++ le ++ ++eah+s a ++q++++   e +++HF++fv++ng+++eLDG++++P+++g+ +    dl 
     EFC36832.1  94 KSLQVASSSFLQDFINGNVGKSSEEIAKSLEGDKRVEEAHESSALSEQNQSEVV-EVTDLHFVCFVEKNGHVFELDGRRKFPMNRGASS---GDLL 185
                    68889***************************************8776666544.445****************************983...5775 PP

                    HH.HHHHHHHT CS
  Peptidase_C12 200 davrkviqeri 210
                    + + kv+++++
     EFC36832.1 186 KDAIKVVKNYM 196
                    5559***9988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       825  (0.0460148); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1417.47
//
Query:       EFC36833.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       503  (0.0280551); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.24s 00:00:00.71 Elapsed: 00:00:00.42
# Mc/sec: 1559.90
//
Query:       EFC36834.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-15   56.0   7.2     0.0031   17.5   0.0    6.3  6  LRR_6       Leucine Rich repeat
    2.1e-13   49.8  16.2    4.3e-08   32.8   0.2    3.5  4  LRR_8       Leucine rich repeat
    2.6e-11   43.6  10.8    4.3e-05   23.8   0.1    4.6  4  LRR_4       Leucine Rich repeats (2 copies)
    2.7e-05   24.0   0.7    5.8e-05   22.9   0.7    1.6  1  F-box-like  F-box-like
    6.6e-05   22.9   2.3        1.2   10.0   0.1    5.7  6  LRR_1       Leucine Rich Repeat
      0.005   16.4   3.2      0.007   15.9   0.4    2.1  2  LRR_9       Leucine-rich repeat
  ------ inclusion threshold ------
       0.02   14.7   0.2       0.05   13.5   0.2    1.7  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.2     1e-05     0.026       5      24 .]     118     137 ..     114     137 .. 0.92
   2 !    7.8   0.0    0.0015       3.8       5      23 ..     142     160 ..     139     161 .. 0.90
   3 !   17.5   0.0   1.2e-06    0.0031       4      19 ..     165     180 ..     162     185 .. 0.87
   4 !    6.7   0.1    0.0033       8.5       5      24 .]     190     209 ..     189     209 .. 0.89
   5 !    6.7   0.1    0.0035       8.8       5      22 ..     214     231 ..     211     233 .. 0.90
   6 ?    1.0   0.0      0.23   5.9e+02       5      16 ..     238     249 ..     235     249 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+s +dI D+Ga++++
  EFC36834.1 118 LTMLDISNHDICDQGAKSIC 137
                 788***************98 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0015
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L+ L +++N I+D Gae +
  EFC36834.1 142 LRVLKIAYNRINDFGAEYI 160
                 99***********999987 PP

  == domain 3  score: 17.5 bits;  conditional E-value: 1.2e-06
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                  Lt+L++sgN+I D+G
  EFC36834.1 165 QLTSLNISGNNIRDKG 180
                 59*************9 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0033
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++  N+Ig++G+  L+
  EFC36834.1 190 LTKLNVCINKIGNQGVVHLS 209
                 89999999********9986 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.0035
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt L++s N ++D+G++ 
  EFC36834.1 214 LTNLNISANIFDDDGVKL 231
                 9***************86 PP

  == domain 6  score: 1.0 bits;  conditional E-value: 0.23
       LRR_6   5 LteLdLsgNdIg 16 
                 Lt L++  N++g
  EFC36834.1 238 LTVLNIGANNFG 249
                 9*****999987 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.1   1.5e-05     0.038      20      61 .]     111     152 ..     109     152 .. 0.95
   2 !   32.8   0.2   1.7e-11   4.3e-08       2      59 ..     141     198 ..     140     200 .. 0.94
   3 !   18.8   1.5     4e-07     0.001       2      61 .]     189     248 ..     188     248 .. 0.96
   4 !   14.2   0.4   1.1e-05     0.028       2      37 ..     213     248 ..     212     258 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.5e-05
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + k+l++L++Ld+sn  +    ++++  +++Lr L + +Nr+
  EFC36834.1 111 SIKNLKGLTMLDISNHDICDQGAKSICEMKQLRVLKIAYNRI 152
                 5799************************************97 PP

  == domain 2  score: 32.8 bits;  conditional E-value: 1.7e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +L++L +  Nr+++ + e  +++++L++L++s N+++    + +s L +L++L++  N
  EFC36834.1 141 QLRVLKIAYNRINDFGAEYISTMKQLTSLNISGNNIRDKGSKYISELDQLTKLNVCIN 198
                 79***************************************************98655 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 4e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+++ N++ + +    +g+++L+ L++s N  +    +  s +++L+ L++  N++
  EFC36834.1 189 QLTKLNVCINKIGNQGVVHLSGMKQLTNLNISANIFDDDGVKLVSEMKQLTVLNIGANNF 248
                 79*****************************************************99985 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 1.1e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37 
                 +Lt+L++s N + + + +  + +++L+vL+++ N+ 
  EFC36834.1 213 QLTNLNISANIFDDDGVKLVSEMKQLTVLNIGANNF 248
                 7*********************************96 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.1     0.022        57      19      33 ..     112     126 ..     100     130 .. 0.73
   2 !   23.8   0.1   1.7e-08   4.3e-05       1      36 [.     140     176 ..     140     182 .. 0.85
   3 !   12.6   0.7   5.6e-05      0.14       2      33 ..     189     222 ..     188     227 .. 0.87
   4 !    6.7   0.0    0.0039       9.9      21      34 ..     233     247 ..     225     253 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.022
                 HHH-TT--EEE-.-S CS
       LRR_4  19 leklpnLkeLdLsgN 33 
                 +++l+ L+ Ld+s+ 
  EFC36834.1 112 IKNLKGLTMLDISNH 126
                 345999999999665 PP

  == domain 2  score: 23.8 bits;  conditional E-value: 1.7e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L+vL ++ N++ d++   ++ +++L++L++sgNn i
  EFC36834.1 140 KQLRVLKIAYNRINDFGAeyISTMKQLTSLNISGNN-I 176
                 58*************99975445************4.4 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 5.6e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 +L++L+   N++   +   l+++++L+ L++s N
  EFC36834.1 189 QLTKLNVCINKIGNQGVvhLSGMKQLTNLNISAN 222
                 6999****78***888899889*********999 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0039
                 H.-TT--EEE-.-S- CS
       LRR_4  21 k.lpnLkeLdLsgNn 34 
                 + +++L++L++  Nn
  EFC36834.1 233 SeMKQLTVLNIGANN 247
                 339********7785 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.7   2.3e-08   5.8e-05       7      36 ..      34      64 ..      33      74 .. 0.91

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 2.3e-08
  F-box-like  7 EiLlqIFsyLpps.dLlrlalVCrrWrrval 36
                +iL++IFs+ +++   l++alV+++W +v+l
  EFC36834.1 34 DILCEIFSFHDFNfLVLNCALVSKQWLTVIL 64
                79******9999977899**********996 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.36   9.3e+02       2      21 ..     118     137 ..     117     139 .. 0.80
   2 ?    2.6   0.0      0.12     3e+02       1      20 [.     141     160 ..     141     163 .. 0.83
   3 !   10.0   0.1   0.00047       1.2       1      22 [.     165     186 ..     165     187 .. 0.87
   4 ?   -2.2   0.0       4.6   1.2e+04       2       8 ..     190     196 ..     189     208 .. 0.69
   5 ?    0.6   0.0      0.56   1.4e+03       2      13 ..     214     225 ..     213     234 .. 0.80
   6 ?    1.6   0.0      0.26   6.6e+02       2      12 ..     238     248 ..     237     261 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.36
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ Ld+sn  + + ++ s++
  EFC36834.1 118 LTMLDISNHDICDQGAKSIC 137
                 7779****999888777776 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr+L + +n++ +++++++
  EFC36834.1 141 QLRVLKIAYNRINDFGAEYI 160
                 59*********988877766 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00047
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L++s+n++ ++++ +++ 
  EFC36834.1 165 QLTSLNISGNNIRDKGSKYISE 186
                 599*********9999998876 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 4.6
       LRR_1   2 LrhLdLs 8  
                 L++L+++
  EFC36834.1 190 LTKLNVC 196
                 8888874 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.56
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L++s n+++
  EFC36834.1 214 LTNLNISANIFD 225
                 899****99985 PP

  == domain 6  score: 1.6 bits;  conditional E-value: 0.26
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L+++ n++
  EFC36834.1 238 LTVLNIGANNF 248
                 99****66655 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1     0.094   2.4e+02     112     147 ..      86     123 ..      60     134 .. 0.64
   2 !   15.9   0.4   2.7e-06     0.007      48     128 ..     122     203 ..     118     220 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.094
       LRR_9 112 lkklellsllknpvtnkkeyrl..yviyklkqlrlldf 147
                 l+++  l + ++++ n+k y++  y i  lk l++ld 
  EFC36834.1  86 LQNIYKLKVARSSINNEKVYKKlsYSIKNLKGLTMLDI 123
                 45555666667777777777643366777777777765 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 2.7e-06
       LRR_9  48 dlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 d+s+ di +    ++  +k+l++l ++ nri   + +   ++ +l++l +++n++++ +  + + +l +l+ l +  n + n+
  EFC36834.1 122 DISNHDICDqgAKSICEMKQLRVLKIAYNRINDFGAEYISTMKQLTSLNISGNNIRDKGS-KYISELDQLTKLNVCINKIGNQ 203
                 666666654114567789***************************************999.9999*******99999998877 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.2     2e-05      0.05       9      38 ..      34      64 ..      19      75 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2e-05
                HHHHHHHHTS-HHH.HHHHCTT-HHHHHHHT CS
       F-box  9 evlrhILerLplsd.llalrrVSkgwrilid 38
                ++l++I+++ ++   +l++++VSk w  +i 
  EFC36834.1 34 DILCEIFSFHDFNFlVLNCALVSKQWLTVIL 64
                58888888877777************99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      262  (0.0146132); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.54
# Mc/sec: 1496.79
//
Query:       EFC36835.1  [L=378]
Description: small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-21   76.9   0.1      2e-21   76.3   0.1    1.3  1  Ras         Ras family
    2.5e-18   66.4   0.0    4.4e-18   65.7   0.0    1.4  1  Roc         Ras of Complex, Roc, domain of DAPkinase
    7.9e-07   28.8   1.1    3.4e-06   26.8   0.3    2.2  2  F-box       F-box domain
    1.6e-06   27.9   0.6    1.6e-06   27.9   0.6    2.1  3  F-box-like  F-box-like
    1.4e-05   24.6   0.0    2.2e-05   24.0   0.0    1.2  1  Arf         ADP-ribosylation factor family
    0.00037   20.6   0.1    0.00067   19.7   0.1    1.4  1  MMR_HSR1    50S ribosome-binding GTPase
     0.0029   17.0   0.1     0.0047   16.3   0.1    1.4  1  Gtr1_RagA   Gtr1/RagA G protein conserved region


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.3   0.1   7.8e-25     2e-21       1     134 [.     209     346 ..     209     367 .. 0.89

  Alignments for each domain:
  == domain 1  score: 76.3 bits;  conditional E-value: 7.8e-25
                 EEEEEESTTSSHHHHHHHHHH....SSCSSSCTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvk....dkFkeeyesTigvdfytkeievd.gkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwv 94 
                 K+vl Gd a GKtsl +  ++    +  ++++++Tigvdf +k++++   +++k+++wD  G e+++++  ++yr+a+++ll+ d +++ + e++k+  
  EFC36835.1 209 KVVLDGDYASGKTSLFNCAMNeipvNASRNHHIPTIGVDFGIKNFQFGdTTKIKMQLWDQSGPERYSRVSLSFYRNASVVLLLIDPSNNFASESMKEKA 307
                 899************98887733335778999************99864789*********************************************** PP

                 HHHHHHSTTTSEEEEEEETTTGGGG-SS-HHHHHHHHHHH CS
         Ras  95 eeikrvaeenvpivLvGnKvDleekravsteegeelakel 134
                 e ik++a++  +++L+ +K D +ekr +s++++ ++a ++
  EFC36835.1 308 ETIKKHASK-AEVILISTKKDKKEKRIISNKQADKFAYDN 346
                 ********5.**************************9654 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.7   0.0   1.7e-21   4.4e-18       1     120 []     209     328 ..     209     328 .. 0.86

  Alignments for each domain:
  == domain 1  score: 65.7 bits;  conditional E-value: 1.7e-21
                 EEEEESSTTSSHHHHHHCHCT....-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE.GHHH.. CS
         Roc   1 KvvlvGdsgvGKtsllkrfve....dkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd.srss.. 92 
                 Kvvl Gd ++GKtsl++  ++    +  ++++ +tigvdf  k+++ +       +++k+k+++WD +G er++ +  +++r+a++++l++d s+++  
  EFC36835.1 209 KVVLDGDYASGKTSLFNCAMNeipvNASRNHHIPTIGVDFGIKNFQ-FG------DTTKIKMQLWDQSGPERYSRVSLSFYRNASVVLLLIDpSNNFas 300
                 89***************9999444455678899*******999873.22......345799*******************************7554433 PP

                 HCHHHHHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  93 enlkeWlkelkkvagkspvilvgnkiDl 120
                 e++ke  + +kk+a+k+ vil+ +k D+
  EFC36835.1 301 ESMKEKAETIKKHASKAEVILISTKKDK 328
                 789**********************995 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.8   0.3   1.3e-09   3.4e-06       5      37 ..       8      41 ..       5      45 .. 0.93
   2 ?   -0.2   0.0      0.39     1e+03       3      19 ..      99     131 ..      97     134 .. 0.76

  Alignments for each domain:
  == domain 1  score: 26.8 bits;  conditional E-value: 1.3e-09
                HS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHH CS
       F-box  5 rLPsevlrhILerLplsd.llalrrVSkgwrili 37
                 LP++++ +IL++ ++++ l+ ++rV+k w +++
  EFC36835.1  8 VLPNDLIGEILSHISHVElLVTFSRVCKYWQRIC 41
                69*****************************998 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.39
                 HHHS-HH................HHHHHHHTS- CS
       F-box   3 lsrLPse................vlrhILerLp 19 
                 +s+++++                vl+++++r +
  EFC36835.1  99 ISSVSEDirscsikekwvdvelsVLKECFKRFS 131
                 778888888888888888888889999999855 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   0.6   6.4e-10   1.6e-06       3      42 ..       8      46 ..       6      48 .. 0.85
   2 ?   -2.9   0.0       2.6   6.6e+03      20      34 ..      95     109 ..      90     113 .. 0.76
   3 ?   -3.5   0.1       3.9   9.9e+03      24      35 ..     274     285 ..     273     287 .. 0.77

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 6.4e-10
  F-box-like  3 rLPdEiLlqIFsyLppsdLlr.lalVCrrWrrvaldtplLW 42
                 LP++++ +I+s+++  +Ll   ++VC++W+r+++ + l+W
  EFC36835.1  8 VLPNDLIGEILSHISHVELLVtFSRVCKYWQRICY-E-LIW 46
                59************877766648**********95.4.788 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.6
  F-box-like  20 dLlrlalVCrrWrrv 34 
                  L+ ++ V+ + r++
  EFC36835.1  95 KLAKISSVSEDIRSC 109
                 578888999888886 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 3.9
  F-box-like  24 lalVCrrWrrva 35 
                  ++V+ +++r a
  EFC36835.1 274 YSRVSLSFYRNA 285
                 688999999876 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   8.5e-09   2.2e-05      16     136 ..     209     338 ..     203     365 .. 0.71

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 8.5e-09
                 EEEEEESTTSSHHHHHHHHHHSSCEE.....CSSSSS..EEEEEEEE...TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHH CS
         Arf  16 rilllGLDnaGKtTilkklkleelvt.....tvPTig..fnveelei...knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeL 104
                 +++l G  ++GKt + +  ++e  v+     ++PTig  f +++ ++    ++k+++wD  G e+  ++  +++++  +v+ ++D +++   e++ke+ 
  EFC36835.1 209 KVVLDGDYASGKTSLFNCAMNEIPVNasrnhHIPTIGvdFGIKNFQFgdtTKIKMQLWDQSGPERYSRVSLSFYRNASVVLLLIDPSNNFASESMKEKA 307
                 55666666789999987666554433344459***985467899987665789*********************************9998877777777 PP

                 HHHCTSGCCTTSEEEEEEE-TTSTT.SS-HHHH CS
         Arf 105 kalleeeelkevallvlaNKqDlpe.alseeel 136
                 +++ ++   +++ +++++ K+D +e  + +++ 
  EFC36835.1 308 ETIKKHA--SKAEVILISTKKDKKEkRIISNKQ 338
                 6665444..444455555666655404444444 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.1   2.6e-07   0.00067       2     113 ..     210     324 ..     209     336 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 2.6e-07
                 EEEEESTTSSHHHHHHHHHTS..TEEESSSTTSSSSEEEEEEE.....ETTEEEEEEECGGCSSHHHHHH.HHHHHHHHHHCTSEEEEEEETT....TT CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltge..kaivsdkpgtTrdinegrvk.....lkgkeielvDtpGliegaseek.glgkaflaleeadlillvvdas....ee 88 
                 v++ G   +GK++L+n  ++e  +    +++  T+ + +g  +     + + +++l+D  G  e    +  +++ +f   ++a+++ll++d s    +e
  EFC36835.1 210 VVLDGDYASGKTSLFNCAMNEipVNASRNHHIPTIGVDFGIKNfqfgdTTKIKMQLWDQSG-PE----RYsRVSLSFY--RNASVVLLLIDPSnnfaSE 301
                 677788889***********98644556677777777777444445554457899999999.77....2225555555..4799*******77555544 PP

                 CSHHHHHHHHHHHHHTTSEEEEEEE CS
    MMR_HSR1  89 klkpldeeleelleeakkplilvln 113
                 ++k++ e++++    +k ++il+ +
  EFC36835.1 302 SMKEKAETIKKHA--SKAEVILIST 324
                 5555555555554..4455666554 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   1.8e-06    0.0047       1     127 [.     209     332 ..     209     367 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.8e-06
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdny.....lardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleed 94 
                 kv+L G   sGKts+ +   +++       +++ ++g+   +++ ++  + +++++lwD  G e++   +l     + +rn +v++ ++D +    + +
  EFC36835.1 209 KVVLDGDYASGKTSLFNCAMNEIpvnasRNHHIPTIGVDFGIKNFQFGDTTKIKMQLWDQSGPERYSRVSL-----SFYRNASVVLLLIDPS---NNFA 299
                 79999********976665555500000555666777777888888888999************9998875.....578999********99...3445 PP

   Gtr1_RagA  95 letlkeilealrqyspeakvfvlihKmDliqed 127
                  e++ke  e+++++  +a+v  +  K D+ +++
  EFC36835.1 300 SESMKEKAETIKKHASKAEVILISTKKDKKEKR 332
                 566778888889999999999888898876543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1032  (0.0575604); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 2516.25
//
Query:       EFC36836.1  [L=436]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (436 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1757  (0.0979977); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.39u 0.20s 00:00:00.59 Elapsed: 00:00:00.34
# Mc/sec: 3858.80
//
Query:       EFC36837.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-12   46.5  17.8    1.5e-06   27.8   0.2    4.5  5  TPR_1     Tetratricopeptide repeat
    1.1e-07   31.4  15.7     0.0004   20.0   0.7    4.3  5  TPR_11    TPR repeat
    5.4e-07   29.2  14.8    0.00015   21.6   0.1    4.4  5  TPR_2     Tetratricopeptide repeat
    6.2e-07   29.1  13.6    9.3e-05   22.4   0.9    4.8  6  TPR_8     Tetratricopeptide repeat
    5.4e-06   26.6   3.6    0.00019   21.7   0.4    3.3  2  TPR_12    Tetratricopeptide repeat
    7.9e-06   25.5   1.1    0.00084   19.2   0.1    3.5  4  TPR_7     Tetratricopeptide repeat
    3.7e-05   23.7   4.4     0.0027   17.7   1.1    3.1  3  MIT       MIT (microtubule interacting and transport) domain
    0.00026   21.6   0.2       0.67   10.9   0.0    3.3  4  TPR_14    Tetratricopeptide repeat
    0.00056   20.1   3.9       0.94   10.0   0.0    4.6  4  TPR_17    Tetratricopeptide repeat
     0.0012   18.7   0.7        2.6    8.0   0.0    3.1  4  TPR_10    Tetratricopeptide repeat
     0.0075   16.8   2.1       0.19   12.2   0.1    3.0  3  TPR_19    Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.046   13.9   0.6      0.046   13.9   0.6    2.3  2  MapZ_EC1  MapZ extracellular domain 1


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.66   9.9e+02      10      20 ..      72      82 ..      71      82 .. 0.91
   2 ?   -2.1   0.2       2.7     4e+03      13      26 ..      85      98 ..      84      98 .. 0.74
   3 !   11.3   0.8   0.00016      0.24       1      33 [.     101     133 ..     101     134 .. 0.89
   4 !   17.9   0.1   1.3e-06    0.0019       2      34 .]     136     168 ..     135     168 .. 0.95
   5 !   27.8   0.2   9.8e-10   1.5e-06       2      32 ..     170     200 ..     169     202 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.66
                HHHHTT-HHHH CS
       TPR_1 10 ayfklgkydeA 20
                +y++l+k+++A
  EFC36837.1 72 VYRYLEKLEQA 82
                8********99 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2.7
                HTT-HHHHHHHHHH CS
       TPR_1 13 klgkydeAleyyek 26
                k+++  +A+e ++k
  EFC36837.1 85 KKKEQGQAVELFNK 98
                66677789999987 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 0.00016
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   1 akalynlGnayfklgkydeAleyyekALelnPn 33 
                 a+ ++  Gn y+k++k+  A++ y  A  + P+
  EFC36837.1 101 ANLYKEEGNKYLKNKKFATAVDLYISACLIAPE 133
                 6789999*****************999888875 PP

  == domain 4  score: 17.9 bits;  conditional E-value: 1.3e-06
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                   + nl+ a+f  ++ +e +++++ A+ l+Pn+
  EFC36837.1 136 VYYSNLASALFFCKRVEESEQACSFAIMLDPNY 168
                 679****************************97 PP

  == domain 5  score: 27.8 bits;  conditional E-value: 9.8e-10
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHST CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnP 32 
                 ka+ +++ +   l+ky+eA+  yekA+el+ 
  EFC36837.1 170 KAYSRMAKVKETLNKYEEAIRNYEKAIELES 200
                 8***************************975 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       1.6   2.4e+03       3      13 ..      72      82 ..      71      82 .. 0.87
   2 ?   -3.3   0.1       5.1   7.6e+03       5      18 ..      84      97 ..      84      98 .. 0.65
   3 !   15.4   0.5   7.2e-06     0.011       1      39 [.     108     146 ..     108     146 .. 0.97
   4 ?    5.0   0.0     0.013        19      20      37 ..     161     178 ..     159     182 .. 0.90
   5 !   20.0   0.7   2.7e-07    0.0004       7      25 ..     182     200 ..     181     202 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.6
      TPR_11  3 ayyeqGkyeeA 13
                +y+ + k+e+A
  EFC36837.1 72 VYRYLEKLEQA 82
                79999999998 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 5.1
      TPR_11  5 yeqGkyeeAieaYk 18
                y++ +  +A+e ++
  EFC36837.1 84 YKKKEQGQAVELFN 97
                56667777887666 PP

  == domain 3  score: 15.4 bits;  conditional E-value: 7.2e-06
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 G+ y +  k+  A+  Y  A+ + P++a  y+nL+ a++
  EFC36837.1 108 GNKYLKNKKFATAVDLYISACLIAPEQAVYYSNLASALF 146
                 9**********************************9975 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.013
      TPR_11  20 AlkldPdnaeayynLGla 37 
                 A+ ldP++  ay+ ++++
  EFC36837.1 161 AIMLDPNYSKAYSRMAKV 178
                 899**********99988 PP

  == domain 5  score: 20.0 bits;  conditional E-value: 2.7e-07
      TPR_11   7 qGkyeeAieaYkkAlkldP 25 
                 ++kyeeAi +Y+kA++l +
  EFC36837.1 182 LNKYEEAIRNYEKAIELES 200
                 69**************986 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       2.5   3.7e+03      10      20 ..      72      82 ..      71      82 .. 0.85
   2 ?   -1.7   0.2       2.9   4.3e+03      12      26 ..      84      98 ..      84      98 .. 0.77
   3 !    8.3   0.3    0.0019       2.8       2      33 ..     102     133 ..     101     134 .. 0.89
   4 !    8.0   0.0    0.0024       3.5       2      34 .]     136     168 ..     135     168 .. 0.94
   5 !   21.6   0.1     1e-07   0.00015       2      31 ..     170     199 ..     169     201 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2.5
       TPR_2 10 ayyklgdyeeA 20
                +y++l ++e+A
  EFC36837.1 72 VYRYLEKLEQA 82
                79999999998 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 2.9
       TPR_2 12 yklgdyeeAleafek 26
                yk+++  +A+e+f+k
  EFC36837.1 84 YKKKEQGQAVELFNK 98
                677777889999986 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0019
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPn 33 
                  ++ + G+ y+k+++++ A++++  A  ++P+
  EFC36837.1 102 NLYKEEGNKYLKNKKFATAVDLYISACLIAPE 133
                 678999*****************999888885 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0024
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                  ++ nl+ a++  ++ ee ++a+  A+ ldPn+
  EFC36837.1 136 VYYSNLASALFFCKRVEESEQACSFAIMLDPNY 168
                 589****************************96 PP

  == domain 5  score: 21.6 bits;  conditional E-value: 1e-07
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleld 31 
                 +a+ +++++ + l++yeeA++ +ekA+el+
  EFC36837.1 170 KAYSRMAKVKETLNKYEEAIRNYEKAIELE 199
                 7999************************96 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       3.2   4.8e+03      10      20 ..      72      82 ..      71      83 .. 0.84
   2 ?    0.0   0.2      0.91   1.4e+03      13      27 ..      85      99 ..      75     101 .. 0.81
   3 ?    0.5   0.0      0.62   9.3e+02       6      17 ..      99     110 ..      99     111 .. 0.88
   4 ?    0.9   0.1      0.46   6.8e+02      11      33 ..     111     133 ..     108     134 .. 0.90
   5 !   10.3   0.1   0.00046      0.68       3      33 ..     137     167 ..     135     168 .. 0.94
   6 !   22.4   0.9   6.2e-08   9.3e-05       2      32 ..     170     200 ..     169     202 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3.2
                HHHHTT-HHHH CS
       TPR_8 10 iylklgdyeeA 20
                +y+ l+++e+A
  EFC36837.1 72 VYRYLEKLEQA 82
                79999999998 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.91
                HTT-HHHHHHHHHHH CS
       TPR_8 13 klgdyeeAkeyyeka 27
                k+++  +A+e ++k 
  EFC36837.1 85 KKKEQGQAVELFNKQ 99
                788889999999986 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.62
                 HHHHHHHHTT-H CS
       TPR_8   6 nlgsiylklgdy 17 
                 +l+++y++ g++
  EFC36837.1  99 QLANLYKEEGNK 110
                 69******9985 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.46
                 HHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8  11 ylklgdyeeAkeyyekaleldpd 33 
                 ylk +++  A+  y  a+ ++p+
  EFC36837.1 111 YLKNKKFATAVDLYISACLIAPE 133
                 8999**********999999986 PP

  == domain 5  score: 10.3 bits;  conditional E-value: 0.00046
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 +y nl+s+++  ++ ee+++++  a+ ldp+
  EFC36837.1 137 YYSNLASALFFCKRVEESEQACSFAIMLDPN 167
                 799**************************98 PP

  == domain 6  score: 22.4 bits;  conditional E-value: 6.2e-08
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleldp 32 
                 +ay +++++ ++l++yeeA+  yeka+el+ 
  EFC36837.1 170 KAYSRMAKVKETLNKYEEAIRNYEKAIELES 200
                 7999************************985 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.2     0.077   1.1e+02      43      68 ..      99     124 ..      71     132 .. 0.78
   2 !   21.7   0.4   1.3e-07   0.00019       4      74 ..     136     198 ..     133     199 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.077
      TPR_12  43 ltattlrnLgrlyralgryeeAlell 68 
                 ++a+ +   g  y++ ++++ A++l+
  EFC36837.1  99 QLANLYKEEGNKYLKNKKFATAVDLY 124
                 47889999999999999999999988 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 1.3e-07
      TPR_12   4 talnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                   ++nla++l+  +r +e+++ +  a  i+   l+p+   ++ ++  ++ + + l++yeeA++ +e+a+++
  EFC36837.1 136 VYYSNLASALFFCKRVEESEQACSFA--IM---LDPN---YSKAYSRMAKVKETLNKYEEAIRNYEKAIEL 198
                 55779****************99999..55...3365...799*************************986 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.099   1.5e+02      17      33 ..      91     107 ..      88     111 .. 0.66
   2 ?    0.3   0.1      0.61   9.2e+02       5      14 ..     100     109 ..      98     127 .. 0.70
   3 ?   -1.3   0.0         2     3e+03       2      10 ..     138     146 ..     138     160 .. 0.61
   4 !   19.2   0.1   5.6e-07   0.00084       1      35 [.     171     205 ..     171     206 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.099
       TPR_7  17 eAielyeqsLaltkdpe 33 
                 +A+el+ ++La  + +e
  EFC36837.1  91 QAVELFNKQLANLYKEE 107
                 78999999885444433 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.61
       TPR_7   5 LarlysrlGd 14 
                 La+ly ++G+
  EFC36837.1 100 LANLYKEEGN 109
                 6777766664 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 2
       TPR_7   2 LlnLarlys 10 
                 ++nLa++ +
  EFC36837.1 138 YSNLASALF 146
                 678888855 PP

  == domain 4  score: 19.2 bits;  conditional E-value: 5.6e-07
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLaltkdpeda 35 
                 a++++a + + l++yeeAi+ ye++++l+++++++
  EFC36837.1 171 AYSRMAKVKETLNKYEEAIRNYEKAIELESSQSVK 205
                 78999999999******************999876 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.95   1.4e+03      29      57 ..      91     112 ..      90     116 .. 0.50
   2 !    5.7   0.0      0.01        15      13      31 ..     110     128 ..     106     130 .. 0.88
   3 !   17.7   1.1   1.8e-06    0.0027       7      33 ..     172     198 ..     168     221 .] 0.83

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.95
         MIT  29 ealelLlqalkekneerrellrekieeYl 57 
                 +a+el+++ l+       +l++e+ ++Yl
  EFC36837.1  91 QAVELFNKQLA-------NLYKEEGNKYL 112
                 56666666665.......33444444443 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.01
         MIT  13 eeDnagnyeeAlelYkeal 31 
                 ++ +++++++A++lY +a+
  EFC36837.1 110 KYLKNKKFATAVDLYISAC 128
                 56789************98 PP

  == domain 3  score: 17.7 bits;  conditional E-value: 1.8e-06
         MIT   7 lvkkAveeDnagnyeeAlelYkealel 33 
                 + ++A  ++  ++yeeA+++Y++a+el
  EFC36837.1 172 YSRMAKVKETLNKYEEAIRNYEKAIEL 198
                 6789999******************97 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       2.1   3.2e+03      17      29 ..      89     101 ..      71     109 .. 0.67
   2 !    6.8   0.0    0.0093        14      11      42 ..     111     142 ..      93     145 .. 0.77
   3 ?    4.2   0.0     0.066        99       7      43 ..     141     177 ..     138     178 .. 0.93
   4 !   10.9   0.0   0.00045      0.67       2      31 ..     170     199 ..     169     206 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 2.1
      TPR_14  17 pdeAiallrrala 29 
                   +A++l+++ la
  EFC36837.1  89 QGQAVELFNKQLA 101
                 4567777777765 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0093
      TPR_14  11 llalGdpdeAiallrralalaPddaeawllla 42 
                 +l + ++++A++l+  a+  aP++a+++  la
  EFC36837.1 111 YLKNKKFATAVDLYISACLIAPEQAVYYSNLA 142
                 445556*******************9998887 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.066
      TPR_14   7 laeallalGdpdeAiallrralalaPddaeawlllaq 43 
                 la+al+   + +e+++++  a+ l+P+   a+ ++a+
  EFC36837.1 141 LASALFFCKRVEESEQACSFAIMLDPNYSKAYSRMAK 177
                 89999999************************99997 PP

  == domain 4  score: 10.9 bits;  conditional E-value: 0.00045
      TPR_14   2 eallalaeallalGdpdeAiallrralala 31 
                 +a+ ++a++ ++l +++eAi+ +++a++l 
  EFC36837.1 170 KAYSRMAKVKETLNKYEEAIRNYEKAIELE 199
                 58999**********************975 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1       0.2     3e+02      18      32 ..      99     120 ..      91     122 .. 0.60
   2 ?    4.2   0.0     0.044        65       7      33 ..     129     155 ..     123     157 .. 0.76
   3 !   10.0   0.0   0.00063      0.94       8      33 ..     164     189 ..     161     190 .. 0.93
   4 ?    1.3   0.0      0.38   5.7e+02       2      11 ..     192     201 ..     191     204 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.2
      TPR_17  18 nLAelll.......knGdlmtA 32 
                 +LA+l++       kn++++tA
  EFC36837.1  99 QLANLYKeegnkylKNKKFATA 120
                 3555665333333377777777 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.044
      TPR_17   7 eldPnnadaynnLAelllknGdlmtAr 33 
                  + P  a+ y nLA +l   ++ ++ +
  EFC36837.1 129 LIAPEQAVYYSNLASALFFCKRVEESE 155
                 567999**********98777666555 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00063
      TPR_17   8 ldPnnadaynnLAelllknGdlmtAr 33 
                 ldPn+++ay  +A++ + ++++++A+
  EFC36837.1 164 LDPNYSKAYSRMAKVKETLNKYEEAI 189
                 69**********************97 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.38
      TPR_17   2 ylkaleldPn 11 
                 y+ka+el+ +
  EFC36837.1 192 YEKAIELESS 201
                 9*****9765 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       4.5   6.7e+03       8      17 ..     100     109 ..      99     110 .. 0.78
   2 ?   -3.5   0.0       7.3   1.1e+04      14      28 ..     113     127 ..     111     128 .. 0.71
   3 !    8.0   0.0    0.0017       2.6       2      23 ..     135     156 ..     135     158 .. 0.90
   4 !    7.5   0.2    0.0026       3.9       6      31 ..     173     198 ..     170     199 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 4.5
      TPR_10   8 Lanalrqrgr 17 
                 Lan++ + g+
  EFC36837.1 100 LANLYKEEGN 109
                 8999988776 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 7.3
      TPR_10  14 qrgrydeAealleea 28 
                 + ++++ A++l++ a
  EFC36837.1 113 KNKKFATAVDLYISA 127
                 567788899888765 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0017
      TPR_10   2 AsslnNLanalrqrgrydeAea 23 
                 A  ++NLa al+  +r +e+e+
  EFC36837.1 135 AVYYSNLASALFFCKRVEESEQ 156
                 5679***************997 PP

  == domain 4  score: 7.5 bits;  conditional E-value: 0.0026
      TPR_10   6 nNLanalrqrgrydeAealleealai 31 
                 + +a +   +++y+eA + +e+a+++
  EFC36837.1 173 SRMAKVKETLNKYEEAIRNYEKAIEL 198
                 55566666789************985 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       1.6   2.3e+03      22      40 ..      88     109 ..      76     110 .. 0.56
   2 !    9.0   0.0    0.0013       1.9       2      67 ..     112     177 ..     111     178 .. 0.89
   3 !   12.2   0.1   0.00013      0.19       7      50 ..     141     194 ..     135     208 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.6
      TPR_19  22 pknaearl...lLAeallalgq 40 
                  + +++ l   +LA+++ + g+
  EFC36837.1  88 EQGQAVELfnkQLANLYKEEGN 109
                 4444444444578888888876 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0013
      TPR_19   2 laegdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddaryasLlAk 67 
                 l+++++a A++l+ +a   +p++a    +LA al+  ++++e e++++ +   dp+ + + s +Ak
  EFC36837.1 112 LKNKKFATAVDLYISACLIAPEQAVYYSNLASALFFCKRVEESEQACSFAIMLDPNYSKAYSRMAK 177
                 78999******************99999*******************9999999997655555665 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 0.00013
      TPR_19   7 yaeAlalleq..........alqedpknaearllLAeallalgqldeAealLda 50 
                 +a+Al + ++          a+  dp+++ a  ++A++   l+ ++eA++  ++
  EFC36837.1 141 LASALFFCKRveeseqacsfAIMLDPNYSKAYSRMAKVKETLNKYEEAIRNYEK 194
                 666666666633333333335556************************976555 PP

>> MapZ_EC1  MapZ extracellular domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.6   3.1e-05     0.046       6      46 ..      81     121 ..      77     144 .. 0.84
   2 ?    0.5   3.1      0.45   6.8e+02      43      83 ..     173     214 ..     167     218 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 3.1e-05
    MapZ_EC1   6 assqeskkekkalkafekeyaafftddketflknsefakls 46 
                 ++  ++k++ +a++ f+k++a+++ ++ ++ lkn +fa   
  EFC36837.1  81 QAGYKKKEQGQAVELFNKQLANLYKEEGNKYLKNKKFATAV 121
                 5666889999***************************6544 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.45
    MapZ_EC1  43 aklseLekkLeklk.gskeYkklkkkldslkkqisaieavNs 83 
                 + + ++++ L+k++    +Y+k+ +   s + + + i++vN+
  EFC36837.1 173 SRMAKVKETLNKYEeAIRNYEKAIELESSQSVKETLIKQVNE 214
                 677889999999997788999998888888888888999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1609  (0.0897429); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1455.61
//
Query:       EFC36838.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      9e-09   35.1   0.1    1.1e-08   34.7   0.1    1.2  1  MRP-S34   Mitochondrial 28S ribosomal protein S34


Domain annotation for each model (and alignments):
>> MRP-S34  Mitochondrial 28S ribosomal protein S34
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.7   0.1   6.4e-13   1.1e-08       1      95 [.      26     115 ..      26     134 .. 0.83

  Alignments for each domain:
  == domain 1  score: 34.7 bits;  conditional E-value: 6.4e-13
     MRP-S34   1 gkrLfeilsnlknfGvGrlvtrkswlqrydePcYlritkvepdmsaenlrkgkawgektfrGkn.egkvkei.sktnkadwrLvpkheeeeflekak 95 
                 g++L+++ls+ +  G+   + rk+w+      +Y+ri kv+   +    ++g +wg   ++Gk  ++++++i  ++ k  w+ +++ + e++ +k  
  EFC36838.1  26 GTNLYDLLSRSPRNGIDLCFKRKTWK----FDSYYRISKVNLSAD---GKHGSVWGLFYYNGKPtKETPEKIhGALKKDLWKGISEVQLEQYETKRI 115
                 679**********************4....359********9887...77*************95666777756666667*9999999999988543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       527  (0.0293937); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.31s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 851.12
//
Query:       EFC36839.1  [L=1487]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1487 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       913  (0.0509231); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.95u 0.26s 00:00:01.21 Elapsed: 00:00:00.48
# Mc/sec: 9254.58
//
Query:       EFC36840.1  [L=804]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.59   10.5   8.2          2    8.8   0.5    2.6  2  Mto2_bdg  Micro-tubular organiser Mto1 C-term Mto2-binding re
          4    7.6   9.1        1.5    9.0   3.3    2.8  2  GIT1_C    G protein-coupled receptor kinase-interacting prote
        5.2    7.2   7.4         27    4.9   0.9    3.7  4  TT1725    Hypothetical protein TT1725


Domain annotation for each model (and alignments):
>> Mto2_bdg  Micro-tubular organiser Mto1 C-term Mto2-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   1.8    0.0066        39      10      50 ..     194     230 ..     192     232 .. 0.80
   2 ?    8.8   0.5   0.00033         2      28      51 ..     240     263 ..     236     264 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0066
    Mto2_bdg  10 erqLkaereaRlldrsgarerLeelkaeNrlLkaeLerdrs 50 
                 ++ L +e+    +  s +re+L++l a  ++Lk e + +++
  EFC36840.1 194 VKELSNEK----RVHSDCREELKKLTAAHEKLKEECSNLKK 230
                 55566665....67789****************99887775 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00033
    Mto2_bdg  28 rerLeelkaeNrlLkaeLerdrsh 51 
                 r++L+e ++ N +L++e++ +rs+
  EFC36840.1 240 RAKLDETEKNNTKLRTEIKFLRSY 263
                 89*******************998 PP

>> GIT1_C  G protein-coupled receptor kinase-interacting protein 1 C term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   3.3   0.00025       1.5      54      90 ..     200     236 ..     189     252 .. 0.73
   2 ?    0.4   0.2      0.12     7e+02      60      87 ..     348     375 ..     290     387 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00025
      GIT1_C  54 enlseetlrtaLkqLtssaerLqeeCeelqeaesesk 90 
                 e+  +++ r++Lk+Lt++ e+L+eeC++l++ +++s 
  EFC36840.1 200 EKRVHSDCREELKKLTAAHEKLKEECSNLKKSTEQSY 236
                 44555667778*******************9433333 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.12
      GIT1_C  60 tlrtaLkqLtssaerLqeeCeelqeaes 87 
                  +++++++L +++ r++++ e+ q++++
  EFC36840.1 348 IIHEKVNKLDENTLRIKTKAEDQQKKKP 375
                 3556799999999999999999988544 PP

>> TT1725  Hypothetical protein TT1725
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.2       1.1   6.8e+03      13      35 ..     232     254 ..     229     255 .. 0.84
   2 ?    4.9   0.9    0.0046        27      12      86 ..     283     357 ..     275     372 .. 0.77
   3 ?   -1.2   0.0      0.34   2.1e+03      44      74 ..     495     525 ..     489     543 .. 0.72
   4 ?    3.5   0.0     0.013        76      54      87 ..     737     773 ..     731     791 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.1
                 --S-HHHHHHHHHHHHTTTEEEE CS
      TT1725  13 kekdpeelaekleklaeeelkLk 35 
                 +e++ +el +kl+++++++ kL+
  EFC36840.1 232 TEQSYKELRAKLDETEKNNTKLR 254
                 567889999******99999986 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0046
                 .--S-HHHHHHHHHHHHTTTEEEEEEEETTEEEES--S------SEEEEEEEE-SSS---HHHHHHHHHHH.HTT CS
      TT1725  12 wkekdpeelaekleklaeeelkLkmitnrGvkvyPegleetfctdhwrcRfvakegkkvskeeileLlerlaeag 86 
                 +++kd ++++e+l+ l++ + +L+m+ nr ++ y  ++++   +d+  ++    +++++ ++e++ + e++++ +
  EFC36840.1 283 KDKKDMHDIQEDLSVLTKLHEQLEMLENRRIEDYSFEIHQAKQVDKSTIKTEFVSDAQLLNNEMMIIHEKVNKLD 357
                 5789999****************************9999999999887776666556655666555555555444 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.34
                 EES--S------SEEEEEEEE-SSS---HHH CS
      TT1725  44 vyPegleetfctdhwrcRfvakegkkvskee 74 
                 + P+++    + d ++ R+ +k  ++v++++
  EFC36840.1 495 ISPNTQAMSKIWDVYKSRYGNKIITDVTTRK 525
                 569999999999*******999444443333 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.013
                 --SEEEEEEEE-...SSS---HHHHHHHHHHH.HTTS CS
      TT1725  54 ctdhwrcRfvak...egkkvskeeileLlerlaeagl 87 
                   d w+ Rf+++   e+++ ++++ l+L+++l++agl
  EFC36840.1 737 NKDIWKKRFKESevkEANNPHNSSTLTLITNLTRAGL 773
                 579*******996655555778888999999988887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (804 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2322  (0.129511); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.26s 00:00:00.87 Elapsed: 00:00:00.40
# Mc/sec: 6037.45
//
Query:       EFC36841.1  [L=432]
Description: NHL repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.3e-10   39.5   0.0    0.00026   20.9   0.0    3.7  3  NHL           NHL repeat
    9.2e-05   22.1   0.5        1.4    8.5   0.1    3.2  3  SGL           SMP-30/Gluconolactonase/LRE-like region
     0.0054   16.6   0.1          4    7.6   0.0    3.0  2  PQQ           PQQ enzyme repeat
     0.0057   16.6   0.0        5.9    6.8   0.0    3.0  3  Phytase-like  Esterase-like activity of phytase
  ------ inclusion threshold ------
      0.022   15.0   0.7       0.56   10.5   0.1    2.6  2  Arylesterase  Arylesterase


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   0.0   6.5e-05      0.23       8      27 ..     103     122 ..     100     123 .. 0.86
   2 ?    2.5   0.0      0.05   1.8e+02      10      27 ..     226     244 ..     223     245 .. 0.84
   3 !   20.9   0.0   7.1e-08   0.00026       3      27 ..     277     302 ..     276     303 .. 0.94

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 6.5e-05
                 EEETTTEEEEEECCCTEEEE CS
         NHL   8 avdsnGdiyVaDsenhrvqv 27 
                 +v+s G++++aD++n r+++
  EFC36841.1 103 VVTSKGELIIADTRNRRIRK 122
                 566************99986 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.05
                 E.TTTEEEEEECCCTEEEE CS
         NHL  10 d.snGdiyVaDsenhrvqv 27 
                 + ++ ++y+a++  +r+++
  EFC36841.1 226 TkDGKELYIAETSANRIRK 244
                 557889**********986 PP

  == domain 3  score: 20.9 bits;  conditional E-value: 7.1e-08
                 SEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvqv 27 
                  P+G+a+d  ++diy++Ds+n+r+++
  EFC36841.1 277 VPSGIAIDsYTNDIYISDSYNNRIRK 302
                 6***********************86 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.043   1.5e+02     189     214 ..     102     127 ..      84     149 .. 0.68
   2 !    8.3   0.0   0.00045       1.6     140     168 ..     224     250 ..     160     256 .. 0.86
   3 !    8.5   0.1   0.00039       1.4     125     164 ..     267     306 ..     260     333 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.043
         SGL 189 lavDaeGnvwvAvwgggkvvrfdpdG 214
                 ++v+++G++++A  ++ +++++d+ G
  EFC36841.1 102 AVVTSKGELIIADTRNRRIRKVDTRG 127
                 45666666666666666666666666 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00045
         SGL 140 awspdgktlYlaDsltrkiwaydvdaegg 168
                  +++dgk lY+a++ +++i ++d++  +g
  EFC36841.1 224 TITKDGKELYIAETSANRIRKVDLK--TG 250
                 5789******************995..33 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00039
         SGL 125 klervlddltipNGlawspdgktlYlaDsltrkiwaydvd 164
                 kl  ++  +++p G+a+++ ++ +Y+ Ds +++i ++d +
  EFC36841.1 267 KLPAIQALVNVPSGIAIDSYTNDIYISDSYNNRIRKVDSK 306
                 6777788899*************************99864 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0    0.0011         4       4      22 ..     233     252 ..     231     260 .. 0.89
   2 !    5.8   0.0    0.0041        15       1      20 [.     288     308 ..     288     310 .. 0.95

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0011
                 EEE.ETTSEEEEEETTTCCE CS
         PQQ   4 ylg.sadGylyAlDadTGkv 22 
                 y++ +  ++++ +D++TG++
  EFC36841.1 233 YIAeTSANRIRKVDLKTGEI 252
                 78889*************96 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0041
                 TEEEEE.ETTSEEEEEETTTC CS
         PQQ   1 gvvylg.sadGylyAlDadTG 20 
                 +++y+  s++++++ +D ++G
  EFC36841.1 288 NDIYISdSYNNRIRKVDSKSG 308
                 789***************998 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.018        64      60      99 ..      86     128 ..      38     142 .. 0.78
   2 ?    2.7   0.0     0.028        99     133     171 ..     212     251 ..     202     276 .. 0.79
   3 !    6.8   0.0    0.0016       5.9      72     126 ..     280     335 ..     278     356 .. 0.72

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.018
  Phytase-like  60 gapfpk...kglDpEgiavapdgtfwvssEggpfilefdadGk 99 
                   g+++p    + +D+ + +v+++g++++++ ++ +i+++d  G 
    EFC36841.1  86 GEDIPAalaQMFDVQSAVVTSKGELIIADTRNRRIRKVDTRGI 128
                   555555555777999************************9985 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.028
  Phytase-like 133 pdgrkLyaalEspldqdgaka.keagsrlrilefdlatgk 171
                   ++g+kL a+ + ++++dg++   +++s+ ri + dl+tg+
    EFC36841.1 212 ASGTKLAAFQQFTITKDGKELyIAETSANRIRKVDLKTGE 251
                   4567888999999999998888888888888888888864 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0016
  Phytase-like  72 giav.apdgtfwvssEggpfilefdad.GkllrelplpaellpaaspdaglrrnrGf 126
                   gia+ + ++++++s+ ++++i+++d + G +++   + + +  ++ +  g ++ +G+
    EFC36841.1 280 GIAIdSYTNDIYISDSYNNRIRKVDSKsGIITTVAGVDNVV-HDKMKGEGFSQDGGY 335
                   79998899*****************9956555555554444.333333555555555 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.054   1.9e+02      52      78 ..     216     242 ..     161     249 .. 0.82
   2 ?   10.5   0.1   0.00015      0.56      41      79 ..     263     301 ..     253     307 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.054
  Arylesterase  52 glssanGInidadkkyiyvadilresi 78 
                   +l +    +i  d k +y+a+  ++ i
    EFC36841.1 216 KLAAFQQFTITKDGKELYIAETSANRI 242
                   45555567899999*******999988 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00015
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresih 79 
                   +s++++    + ++ + GI id+    iy++d+ ++ i 
    EFC36841.1 263 FSGDKLPAIQALVNVPSGIAIDSYTNDIYISDSYNNRIR 301
                   677777777788999******************999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       461  (0.0257125); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 2580.41
//
Query:       EFC36842.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.5e-08   33.9   0.0    4.4e-08   33.1   0.0    1.5  1  Abhydrolase_1  alpha/beta hydrolase fold
    0.00064   19.1   0.0      0.001   18.4   0.0    1.4  1  Hydrolase_4    Serine aminopeptidase, S33


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.1   0.0     5e-12   4.4e-08      21     135 ..      31     137 ..      20     275 .. 0.76

  Alignments for each domain:
  == domain 1  score: 33.1 bits;  conditional E-value: 5e-12
                    HHHHHHHTTSEEEEEEETTSTTSSSTTTGB.CHHSHHHHHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHHHGGGEEEEEEESECSSCCHHHHH CS
  Abhydrolase_1  21 lapaLakdgfdvillDlrGvgySspapacinddygtasvaddldrildalgddkltlvGhSmGGmialayaaeyperVkalvllgaidpaasliea 116
                    l++ L+k+  + ++l   G+g+S+++p +++   g+ ++++++  i ++    ++ +++hS  +++a+a+a+eype  ++++ll +     s+++ 
     EFC36842.1  31 LIRSLSKQNIRACVLERGGYGFSDTGPLPRD---GNHTLNEIVSTIYESRMRTPFLYIAHSSASFTARALASEYPELLSGMILLHP-----SHEDQ 118
                    678899999999999*************765...8889************************************************.....77777 PP

                    HHHHHHHHHCHHCHHHHHH CS
  Abhydrolase_1 117 qrqqaksfpdffdgyaadc 135
                    ++  +k++ +  d++++  
     EFC36842.1 119 ELILLKQVKNLTDNDIQLR 137
                    7777777777777776644 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   1.2e-07     0.001      20     122 ..      28     126 ..      20     151 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.2e-07
  Hydrolase_4  20 yaelaeaLaaqGfavyalDhrGhGrsegkrghvpsfddyvdDlaafvekvkeehpelplfllGhSmGGliallyllrypdkvaglilsaPalkikakl 117
                  ++ l++ L +q++  + l   G+G s+      p+  d    l+++v+++ e   ++p+  ++hS  +++a +++ +yp+ ++g+il  P  + ++ +
   EFC36842.1  28 MKPLIRSLSKQNIRACVLERGGYGFSDTGPL--PR--DGNHTLNEIVSTIYESRMRTPFLYIAHSSASFTARALASEYPELLSGMILLHPSHEDQELI 121
                  4568999999999999999999999974444..33..33344788899999999************************************99888665 PP

  Hydrolase_4 118 kappl 122
                   ++++
   EFC36842.1 122 LLKQV 126
                  34444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       751  (0.0418874); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2244.31
//
Query:       EFC36843.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      250  (0.0139439); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.55
# Mc/sec: 1347.42
//
Query:       EFC36844.1  [L=114]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.2e-17   62.4   3.1    5.1e-17   61.8   3.1    1.3  1  zinc_ribbon_13  Nucleic-acid-binding protein containing Zn-ri
  ------ inclusion threshold ------
       0.02   15.1   1.0      0.024   14.9   1.0    1.1  1  RhoGEF          RhoGEF domain
      0.075   13.1   0.1        0.1   12.6   0.1    1.1  1  YpjP            YpjP-like protein
       0.66    9.9   4.1        9.7    6.2   0.4    2.3  2  RNA_POL_M_15KD  RNA polymerases M/15 Kd subunit


Domain annotation for each model (and alignments):
>> zinc_ribbon_13  Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.8   3.1   1.1e-20   5.1e-17       1      53 [.      52     104 ..      52     111 .. 0.93

  Alignments for each domain:
  == domain 1  score: 61.8 bits;  conditional E-value: 1.1e-20
  zinc_ribbon_13   1 kCpKCgnteaevkevaatGsglskifdvqnkkfitvsCknCgYtelYkaetse 53 
                     kC+KCg +e ++++v+ +G+ ls+if+vqn+ fit sC +C+Y+e Y++ +++
      EFC36844.1  52 KCKKCGYKELHKGQVRESGGLLSQIFNVQNRMFITLSCDRCSYSEYYETYQNS 104
                     7**********************************************987765 PP

>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   1.0   5.3e-06     0.024      16     101 ..      16     105 ..       4     111 .. 0.63

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 5.3e-06
                 HHHHHHHTHCCCHHCTCCHHHHHHHHCTTHHHHHHHHHHHH....HHHHHHHH.HHHTTSS-S-SHHHHHHHHSTHHH.......HHHHHHCHHHHH CS
      RhoGEF  16 LkvlvevylkplselevlseeeikiiFsnieeilelhrsfl....leeLeerlkeseeqkeaqsigdvflkfadkfkk.......YseYcsnypnal 101
                 L++l ++ l++++     s +  ++iF + eeil+ h+++      +eL++ +     +++   ++++f+   + f         YseY + y+n+ 
  EFC36844.1  16 LNTLNNIGLSIVD---SSSTNTSNKIFPKQEEILKQHHQKCkkcgYKELHKGQ----VRESGGLLSQIFNVQNRMFITlscdrcsYSEYYETYQNSF 105
                 4444455454444...346778889************8888777777777766....2233333333333322222223446677999999999985 PP

>> YpjP  YpjP-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   2.3e-05       0.1      15      81 ..      15      82 ..       5      85 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.3e-05
        YpjP 15 eeqsllKlGkkiaekiedefeeeilpkieevieellekveeekleeleise.kpasgkgEkifhiynk 81
                + ++l+ +G  i +  + + +++i+pk ee++++ ++k ++  ++el+  + ++++g   +if++ n+
  EFC36844.1 15 TLNTLNNIGLSIVDSSSTNTSNKIFPKQEEILKQHHQKCKKCGYKELHKGQvRESGGLLSQIFNVQNR 82
                556788999***************************99987766665543313478888999999886 PP

>> RNA_POL_M_15KD  RNA polymerases M/15 Kd subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.4    0.0022       9.7      23      31 ..      52      60 ..      41      60 .. 0.80
   2 ?    4.9   0.3    0.0052        23      22      31 ..      87      96 ..      78     100 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0022
                    EESSSS-EE CS
  RNA_POL_M_15KD 23 eCrqCgYee 31
                     C +CgY+e
      EFC36844.1 52 KCKKCGYKE 60
                    4******96 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0052
                    EEESSSS-EE CS
  RNA_POL_M_15KD 22 feCrqCgYee 31
                    + C+ C+Y e
      EFC36844.1 87 LSCDRCSYSE 96
                    78******76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       996  (0.0555525); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.42u 0.30s 00:00:00.72 Elapsed: 00:00:00.46
# Mc/sec: 739.11
//
Query:       EFC36845.1  [L=446]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-64  212.6  36.5    4.8e-13   48.6   0.1    8.8  9  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.6   1.7e-08   0.00031       2      49 .]      13      60 ..      12      60 .. 0.94
   2 !   34.6   0.3   6.5e-13   1.2e-08       2      49 .]      38      85 ..      38      85 .. 0.97
   3 !   34.3   0.1     8e-13   1.4e-08       1      49 []      62     110 ..      62     110 .. 0.99
   4 !   32.8   0.1   2.3e-12   4.1e-08       1      38 [.     112     149 ..     112     161 .. 0.87
   5 !   48.6   0.1   2.7e-17   4.8e-13       1      49 []     163     210 ..     163     210 .. 0.98
   6 !   43.7   0.1   9.4e-16   1.7e-11       1      46 [.     187     231 ..     187     234 .. 0.93
   7 !   27.3   0.1   1.2e-10   2.2e-06       1      49 []     212     258 ..     212     258 .. 0.92
   8 !   38.2   0.4   4.7e-14   8.4e-10       8      49 .]     268     309 ..     259     309 .. 0.92
   9 !   14.7   0.2     1e-06     0.019       1      28 [.     311     335 ..     311     335 .. 0.91

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.7e-08
     DUF4116  2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                +E  l ++++++ +l+++  eLkn +++vl  + q+ ++l+ + +eLr
  EFC36845.1 13 EERQLRIIRIDPVCLEHCKGELKNSRQLVLDYILQDRKILESLNDELR 60
                566799*****************************************8 PP

  == domain 2  score: 34.6 bits;  conditional E-value: 6.5e-13
     DUF4116  2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                r++vl ++ ++ ++l+ l++eL+nD+ei+  A+k +  al++as eL+
  EFC36845.1 38 RQLVLDYILQDRKILESLNDELRNDREIIRLAIKEHYGALKFASAELQ 85
                799*****************************************9996 PP

  == domain 3  score: 34.3 bits;  conditional E-value: 8e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEi+  a+k +  alk++s eL+nDk ++ +A+  +  +++yaseeL+
  EFC36845.1  62 DREIIRLAIKEHYGALKFASAELQNDKSLLQEALLYDTGNYNYASEELK 110
                 9**********************************************97 PP

  == domain 4  score: 32.8 bits;  conditional E-value: 2.3e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 D+Ei   ++ ++g++++y++e++kn +++v kA++++ 
  EFC36845.1 112 DKEILEFLIGRDGCYFEYAPESWKNSRDFVVKAIRNSM 149
                 9**********************************643 PP

  == domain 5  score: 48.6 bits;  conditional E-value: 2.7e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+++le+v++ gs ++ ++ e+k+D++ivl+Av+ +g++l+yas++L+
  EFC36845.1 163 DRDLILEYVRRIGS-IEEIPQEYKQDRDIVLEAVQLDGNNLKYASHSLQ 210
                 9************9.*******************************996 PP

  == domain 6  score: 43.7 bits;  conditional E-value: 9.4e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 Dr+ivleav+ +g++lky+s++L++D+e+++ Av+ ng +l+ + e
  EFC36845.1 187 DRDIVLEAVQLDGNNLKYASHSLQQDRELLIIAVR-NGLSLRNINE 231
                 9**********************************.9988887765 PP

  == domain 7  score: 27.3 bits;  conditional E-value: 1.2e-10
     DUF4116   1 DrEivleavkkngsalkylsee.LknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+   av++ g++l++++e+ L  D+eiv +A++ + ++l+y++ee+r
  EFC36845.1 212 DRELLIIAVRN-GLSLRNINESeL--DREIVYEACRYDTHPLKYVPEEYR 258
                 99**9****98.9******96636..**********************87 PP

  == domain 8  score: 38.2 bits;  conditional E-value: 4.7e-14
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 a++ n s+++y+se+L+n+++++ k  ++ng+ + y+++ Lr
  EFC36845.1 268 AFSENASSFEYVSERLRNNIDFIRKLTRINGYLIQYIPKYLR 309
                 5778899*********************************98 PP

  == domain 9  score: 14.7 bits;  conditional E-value: 1e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDke 28 
                 DrEi+l+a+++ g+  +ylse+L+nDke
  EFC36845.1 311 DREIALNAIRH-GC--NYLSEDLQNDKE 335
                 9**********.66..47*********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (446 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       525  (0.0292822); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2612.47
//
Query:       EFC36846.1  [L=893]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-05   24.8   1.4      7e-05   22.7   0.8    2.6  2  Exo_endo_phos_2  Endonuclease-reverse transcriptase
     0.0088   15.6   0.0      0.018   14.6   0.0    1.5  1  Exo_endo_phos    Endonuclease/Exonuclease/phosphatase family
  ------ inclusion threshold ------
      0.025   14.9   2.4      0.051   13.8   1.0    2.2  2  Alkyl_sulf_C     Alkyl sulfatase C-terminal
      0.053   13.3   0.0       0.19   11.5   0.0    2.0  1  DRTGG            DRTGG domain
       0.13   12.7   1.2       0.95    9.9   0.3    2.9  2  FlaC_arch        Flagella accessory protein C (FlaC)
       0.34   11.2  16.5        5.6    7.3   0.5    3.9  3  DUF948           Bacterial protein of unknown function (DUF94


Domain annotation for each model (and alignments):
>> Exo_endo_phos_2  Endonuclease-reverse transcriptase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.8   5.2e+03      56      78 ..     406     428 ..     399     435 .. 0.81
   2 !   22.7   0.8   2.3e-08     7e-05       2     104 ..     504     617 ..     503     626 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.8
  Exo_endo_phos_2  56 rgeeLiefleehslsllnllksg 78 
                      +++++++f+e++s+++ln ++++
       EFC36846.1 406 KQSQMLSFIEDQSIHVLNVQETH 428
                      5678899********99987765 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 2.3e-08
  Exo_endo_phos_2   2 liisvYippsd.......elenlestlekllselksp..kiiilGDfNakhplWgsedtdssargeeLiefleehslsll....nllksgptfk 82 
                      +i+++Y p +d        + n+ + l+ ++++      ++iilGD+Na+ + + ++      ++++L+ef+++  l  +    n++  + + k
       EFC36846.1 504 RIFNWYGPANDyninrqqFMINTINILTPIIQSSVLHneRVIILGDLNATTTTYTKTYH--GPHEKQLAEFCNSLRLFDIapaiNRPSHQQRNK 595
                      7899999999999987773444555555555554333459**************99554..5*************9986645545544445555 PP

  Exo_endo_phos_2  83 ssngsstiDltltsdnlalskl 104
                      +s+g s  D +++++  +++++
       EFC36846.1 596 QSQGFSRPDHIISTHADHVDCE 617
                      5555799999999998888833 PP

>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   5.9e-06     0.018      24     197 ..     412     563 ..     371     622 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 5.9e-06
                    HHHHHCTTSEEEEEEEBSCTCHHHHHHHHH...TTCEEEEECCH....ECSSSTTSSEEEEEECSTEEEEEEEEEEETSSSSGCEEEEEEEEEEEE CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  24 dlltaydaDvlgLQEvdddelsriplllal...ggflgasstsp....tgggggggnggavlsrfpltslfrrtfiefndlvaalrreplaakleq 112
                    + ++     vl +QE++  + ++ ++   +   ++f+ +++ s       +  ++g g+a+ +++++ ++     + ++++++ +r++ l+   +q
     EFC36846.1 412 SFIEDQSIHVLNVQETHLPSSALSEH---YwqnKHFRSFFYPSLvftsNAPETDKGAGVATIVKPSPLTK-----VLTFIEHVVGRITELILEHKQ 499
                    44444444677778855555443333...133477777777777888889999**************666.....344555555555555555555 PP

                    EEE..........CCCHHGHHHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-SSSTSGGGBSCGHHHHHHCTTTHHSSCESCETTTTTTTTTTTEB CS
                    xxx..........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 113 lni..........ashrdhdlvrdlqllalllqvealnadrgapvivaGDfNarpsdddsrvlrtrglalapapvglyllgggptptyvtraggs 197
                    l +          ++   ++   +   +  l  +++ +  ++++vi++GD+Na                               t+t+ t+++++
     EFC36846.1 500 LGVlrifnwygpaNDYNINRQQFMINTINILTPIIQSSVLHNERVIILGDLNA-------------------------------TTTTYTKTYHG 563
                    555777899888999999999999999999999999999**************...............................55555555554 PP

>> Alkyl_sulf_C  Alkyl sulfatase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   1.0   1.7e-05     0.051      44     123 ..     283     367 ..     257     368 .. 0.85
   2 ?   -1.4   0.0      0.87   2.6e+03      63      84 ..     735     756 ..     712     770 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.7e-05
                   TEEEEEEEETTEEEE.......ECT---..TTSSEEEEE-HHHHHHHHTTSS-HHHHHHTTTEEEEE-TCHHHHHHCTB----TT--S CS
  Alkyl_sulf_C  44 dekyllrlsngvLth......trkaaqa..ddadltvtltreqLvalllgkatlgkevaagklkieGdaealakllslldefdpaFnI 123
                    +++ +r+  ++L++        k+  +  ++++ t++++ +++ +l +  a+ +k +a   +++e + ++l++ +s++++   +F+I
    EFC36846.1 283 STQWKVRVVKATLNNkvaylsINKK--EitNNVTETIKVKNQAFKNLSF-SAKVAKSIAHRMANVETKISELTTTMSMINKTVARFKI 367
                   4689999999999997776652232..1459****************96.678999**************************999998 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.87
                   ---TTSSEEEEE-HHHHHHHHT CS
  Alkyl_sulf_C  63 aqaddadltvtltreqLvalll 84 
                    ++++++l ++l +++L++l+ 
    EFC36846.1 735 FSSNNVELKLKLAKQELNSLIG 756
                   4458999***********9983 PP

>> DRTGG  DRTGG domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   6.4e-05      0.19       7      95 ..      95     196 ..      93     202 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 6.4e-05
                 T-EEEE--..SS--E-EEEE-SS-HHHHHHHHHTSEEEEEETT-HHHHHHHTT-T............EEEEEEE.TT----HHHHHHHHHHT--EEE-S CS
       DRTGG   7 gaevlnggeeelrrvekvvvgamsvenmlerlkegdlvivpGDRediqlaaleag............iaalilT.gglepseevlklaeeaglpvlsve 92 
                 +++ + +++ +++r +++++  +s++++ ++ + +++v+v+ D+  ++l ++ ++            + ++il  +++++  + ++ a +a++p+++ +
  EFC36846.1  95 DGTSIIAEDGDSDRNSDISMEERSIDKLRRHHRYNRAVVVSTDNVSAILDTIGMKddsiygsrvvesLGCIILFfKNAKLLTSAVTAASRAKIPMFAQT 193
                 6777888899********************************************99***********88888765999999999999999999999877 PP

                 S-H CS
       DRTGG  93 ldt 95 
                 + t
  EFC36846.1 194 TKT 196
                 766 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.3   0.00032      0.95      12      42 ..     337     372 ..     331     379 .. 0.80
   2 ?   -1.5   0.0       1.1   3.4e+03      22      40 ..     800     818 ..     790     825 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00032
   FlaC_arch  12 lsteletvkkeneelsksveelkenV.....kdlls 42 
                 +  ++++v+++++el ++  +++++V     kd+l+
  EFC36846.1 337 IAHRMANVETKISELTTTMSMINKTVarfkiKDILD 372
                 556899999999999999999999997766666665 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.1
   FlaC_arch  22 eneelsksveelkenVkdl 40 
                  n+ +sk  e++  + +++
  EFC36846.1 800 HNKTISKHFEDMSNTTQKV 818
                 5778888888888887776 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   4.3    0.0083        25      23      88 ..     287     352 ..     278     353 .. 0.89
   2 ?    5.3   0.2     0.008        24      20      59 ..     665     704 ..     660     725 .. 0.85
   3 ?    7.3   0.5    0.0019       5.6      31      86 ..     800     850 ..     792     853 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0083
      DUF948  23 klkktldeaaatieelekqvdpilkevedllakvnelledvneklekvdplteavadlgesvseln 88 
                 k++ +   +++ ++ l  + ++i+++v+++++  n+  ++++   +  +++ + +a++ +++sel+
  EFC36846.1 287 KVRVVKATLNNKVAYLSINKKEITNNVTETIKVKNQAFKNLSFSAKVAKSIAHRMANVETKISELT 352
                 55666667888899999999********************************************98 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.008
      DUF948  20 vllklkktldeaaatieelekqvdpilkevedllakvnel 59 
                 +l k  ktl+e+++ +++++ q ++++++  +l+++ +++
  EFC36846.1 665 FLTKSPKTLKEVQKVLQDITVQYGKVVNDKPKLITNNKRI 704
                 6778889999999999999999999999988888887764 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0019
      DUF948  31 aaatieelekqvdpilkevedllakvnelledvneklekvdplteavadlgesvse 86 
                  ++ti +  +++ +++++v+++l  +n+     n+kl++      +v+dlg+++++
  EFC36846.1 800 HNKTISKHFEDMSNTTQKVTKALPDINK-----NRKLKSWRLTHISVKDLGKTIKK 850
                 5788888888999999999999999999.....99******************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (893 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1348  (0.0751855); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.79u 0.33s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 5039.45
//
Query:       EFC36847.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       589  (0.0328518); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 1094.22
//
Query:       EFC36848.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       914  (0.0509789); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1212.33
//
Query:       EFC36849.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00043   21.2   0.0     0.0012   19.7   0.0    1.7  2  Trypsin_2  Trypsin-like peptidase domain


Domain annotation for each model (and alignments):
>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.24   4.3e+03      69     110 ..     112     152 ..     106     177 .. 0.73
   2 !   19.7   0.0   6.7e-08    0.0012      69     150 .]     185     279 ..     139     279 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.24
   Trypsin_2  69 glpplplgpsealkggepvyvvGyplggeksgsvssGivsgv 110
                 ++ p  +g+s+  k+g ++y+ ++ l+++++ ++ + i ++ 
  EFC36849.1 112 QFSPSYIGSSSIEKEG-TIYCASNDLFSPHQVMMKEKIKRKF 152
                 4556668889988999.9999999999888865555544444 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 6.7e-08
   Trypsin_2  69 glpplplgpsealkggepvyvvGyplggeksg....................svssGivsgvve.....sesaasgegesflqtdaatspGsSGGplfd 142
                 + +++ ++  ++++++ pv+v+Gyp +  k                                 +       +++++++  ++  ++    G+ G+++f 
  EFC36849.1 185 KTEFIVPCAYNQVEET-PVIVIGYPTRPSKAQilnayeippkrrafdaifsyN---------YKtasigKIKHSTNPDFMLISNATCF--GMEGSAVFS 271
                 4444445556667777.*******95555544444445555554333322221.........22444223333444555555666667..********* PP

   Trypsin_2 143 sdGrvvGl 150
                  +G+++G+
  EFC36849.1 272 IKGELIGI 279
                 *******8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       434  (0.0242066); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2160.05
//
Query:       EFC36850.1  [L=332]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (332 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1927  (0.10748); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 1925.74
//
Query:       EFC36851.1  [L=315]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.4e-13   49.3   3.9    6.4e-13   48.8   3.9    1.2  1  Yip1      Yip1 domain


Domain annotation for each model (and alignments):
>> Yip1  Yip1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.8   3.9   3.6e-17   6.4e-13      13     161 ..     160     298 ..     150     313 .. 0.84

  Alignments for each domain:
  == domain 1  score: 48.8 bits;  conditional E-value: 3.6e-17
        Yip1  13 kkepp.............ilrapdlallllalltlllgllaslnlgqtlasgeevqgltlssllgaiiggylglllgllllalllhliakllggkgsfk 98 
                  + ++             +l++ dla++l+++l+l ++ll+                  +++++ +i+g ++   +g+l + +ll+l++  l  ++ + 
  EFC36851.1 160 QQHHRnssmsseestiqhLLKDMDLAGPLIFCLALGFTLLLK-----------------GKIHFNYIYGVVV---IGCLSIYVLLNLMCP-LSKHIELQ 237
                 5555556666666677778899********************.................8999***999999...9***********666.4589999* PP

        Yip1  99 qtlsvvgyallPlilgaliaillllllgtllllvgllaliWslvllylglkaahnlskkkall 161
                  ++s++gy+llP+++++l++ ll +  ++++l+++++a++Ws++  ++++ aa ++s  + l+
  EFC36851.1 238 HCISILGYGLLPMVVLGLLTTLLPF--PYVSLVLSAIAVFWSTYGSSTMFVAALGMSHQRMLV 298
                 *******************997754..4469*************************9887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1161  (0.0647554); expected 358.6 (0.02)
Passed bias filter:                      676  (0.0377043); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 1981.43
//
Query:       EFC36852.1  [L=138]
Description: histone H3 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-50  170.3   4.7    2.6e-50  170.2   4.7    1.0  1  Histone        Core histone H2A/H2B/H3/H4
    1.7e-05   25.4   0.8    1.9e-05   25.3   0.8    1.2  1  PAF            PCNA-associated factor histone like domain
    7.9e-05   22.7   0.3    7.9e-05   22.7   0.3    1.6  2  CENP-T_C       Centromere kinetochore component CENP-T histon
     0.0003   21.1   0.1    0.00046   20.5   0.1    1.2  1  CENP-S         CENP-S protein
  ------ inclusion threshold ------
      0.012   15.9   0.6      0.023   14.9   0.1    1.7  2  CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) a
       0.11   12.5   0.9       0.15   12.1   0.1    1.6  2  TFIID-31kDa    Transcription initiation factor IID, 31kD subu


Domain annotation for each model (and alignments):
>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  170.2   4.7   8.6e-54   2.6e-50       1     131 []       1     134 [.       1     134 [. 0.99

  Alignments for each domain:
  == domain 1  score: 170.2 bits;  conditional E-value: 8.6e-54
                 XXEESXEEEXXXXEEXXXXXXXXXXHT...TS-SSSSB--TTT-XTTHHHHHHHHHHHHXXSXXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHH CS
     Histone   1 marekekarkesektapekkvsakker...kasskskkkkkrryrpgtvalkeirkyqkstdlliqklpfaRvvreivksekedlrisaeavlalqeal 96 
                 mar+k++ark+++++ap+k++++k +r   k++s+   kk++ry+pgtval+eirkyqkst+lli+klpf+R+vrei ++ k+dlr+++ avlalqea+
  EFC36852.1   1 MARTKQTARKSTGGKAPRKQLASKAARksaKQPSTGGLKKPHRYKPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDYKSDLRFQSNAVLALQEAS 99 
                 9***********************999999999****************************************************************** PP

                 HHHHHHHHHHHHHHHHHTTXSEEXHHHHHHHHHHT CS
     Histone  97 EallvelfeeAnllakhaKRvTitpkDiqlArrlr 131
                 Ea+lv+lfe++nl+a+haKRvTi++kD+qlA r+r
  EFC36852.1 100 EAYLVSLFEDTNLCAIHAKRVTIMQKDMQLAKRIR 134
                 *********************************97 PP

>> PAF  PCNA-associated factor histone like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.3   0.8   6.3e-09   1.9e-05       1      62 [.       1      60 [.       1      98 [. 0.86

  Alignments for each domain:
  == domain 1  score: 25.3 bits;  conditional E-value: 6.3e-09
         PAF  1 mVRTkAdvssarkavaakAprkslgasssssssssssp..kkkkkkyvGGNpvcpRptPaWQKp 62
                m RTk ++   rk  ++kAprk+l+++   +s++  s+   kk + y +G  v  R++ + QK 
  EFC36852.1  1 MARTKQTA---RKSTGGKAPRKQLASKAARKSAKQPSTggLKKPHRYKPG-TVALREIRKYQKS 60
                99******...****************99999998888634444555566.7899999999996 PP

>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1       2.1   6.3e+03      15      23 ..      20      28 ..       7      36 .. 0.62
   2 !   22.7   0.3   2.6e-08   7.9e-05      14      75 ..      71     131 ..      51     137 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.1
    CENP-T_C 15 klakrfaka 23
                +la+++a++
  EFC36852.1 20 QLASKAARK 28
                344444433 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 2.6e-08
    CENP-T_C  14 kklakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilLmk 75 
                 ++l++++a+   s  + + +a+ al++as+ ++  + eD +  a Ha+R ti ++D+ l  k
  EFC36852.1  71 QRLVREIAQDYKSDLRFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMQKDMQL-AK 131
                 678888888888999*****************************************964.44 PP

>> CENP-S  CENP-S protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   1.6e-07   0.00046      14      71 ..      73     132 ..      67     135 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.6e-07
      CENP-S  14 iveeeaa..ekeveatkqfiaaltelvykqlenlakDLeaFakHAkRstittdDvlLlaR 71 
                 +v+e+a+  ++++++ ++++ al e   + l +l +D ++ a HAkR ti ++D+ L  R
  EFC36852.1  73 LVREIAQdyKSDLRFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMQKDMQLAKR 132
                 455544323667789999**************************************9887 PP

>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.9   5.6e+03      39      48 ..      20      29 ..      19      33 .. 0.63
   2 ?   14.9   0.1   7.8e-06     0.023       2      64 ..      67     130 ..      66     130 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.9
                   HHHHHHHHHH CS
  CBFD_NFYB_HMF 39 elaseAaeic 48
                   +las+Aa++ 
     EFC36852.1 20 QLASKAARKS 29
                   5777777655 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 7.8e-06
                    XXXHHHHHHHHHCC.TTXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHH CS
  CBFD_NFYB_HMF   2 eLPiarvkkImksd.pdarkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklA 64 
                    +LP  r  + + +d +++ ++ + A   ++e+ e ++ +l + ++  + ++kr ti++++++lA
     EFC36852.1  67 KLPFQRLVREIAQDyKSDLRFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMQKDMQLA 130
                    78988887777777799********************************************998 PP

>> TFIID-31kDa  Transcription initiation factor IID, 31kD subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.5   4.6e+03      73      91 ..      10      28 ..       4      34 .. 0.61
   2 ?   12.1   0.1   5.1e-05      0.15      22      67 ..      86     131 ..      70     138 .] 0.87

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.5
  TFIID-31kDa 73 kqfkepppkelLlelAaer 91
                 k+  ++ p++ L + Aa++
   EFC36852.1 10 KSTGGKAPRKQLASKAARK 28
                 4455566777777666554 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 5.1e-05
  TFIID-31kDa  22 eyeerVvlqLldfayrytssvLedAkvlaehakkkevslddvrlAi 67 
                   ++++ vl L +    y +s++ed +++a hak+ ++  +d++lA 
   EFC36852.1  86 RFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMQKDMQLAK 131
                  578899999***********************************94 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (138 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       510  (0.0284455); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.49
# Mc/sec: 854.87
//
Query:       EFC36853.1  [L=320]
Description: hypothetical protein NAEGRDRAFT_82085 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-18   65.3   0.1    1.1e-17   64.2   0.1    1.6  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.2   0.1     6e-22   1.1e-17       2     100 ..       8     127 ..       7     130 .. 0.90

  Alignments for each domain:
  == domain 1  score: 64.2 bits;  conditional E-value: 6e-22
                 EEEEEEEEEESSSSSSTTSSCEEEEEEEE...............ECEEEEEE-SCSSSSSSEEEEEEEE.EESC...HTTSEEEEEEEEECSSSTEEEE CS
          C2   2 klevtvieAknLpnkdkkgssdpyvkvsl...............dgkqkakTrviknslnPvWnekftf.evae...leeakLeveVfdndrlskddfi 81 
                 +levt++++ +L++ d +g sdpyv v+                ++  k+kT+++k+ lnP+Wne+ tf +v+     e  k+ ++Vfd+d+ls+dd i
  EFC36853.1   8 TLEVTIKNGVDLEAADFNGFSDPYVIVQTkalvdeklpsylkeaAKGWKQKTSIKKKDLNPTWNETKTFhSVYCldkGEGIKVLFKVFDWDMLSRDDAI 106
                 69*****************************************9999999***99**************8888899889999***************** PP

                 EEEEEEGHH..HHTTHHHHEE CS
          C2  82 Gkveiplst..llsgeeaegw 100
                 Gk+ei ++   l++++e++++
  EFC36853.1 107 GKAEIVINFdkLEHNKEYSET 127
                 ***987554337777766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       585  (0.0326287); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.45
# Mc/sec: 2121.59
//
Query:       EFC36854.1  [L=364]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.39   11.1   2.6       0.32   11.4   0.7    1.8  2  YvfG      YvfG protein


Domain annotation for each model (and alignments):
>> YvfG  YvfG protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.7   1.8e-05      0.32      14      51 ..      27      64 ..      21      74 .. 0.87
   2 ?   -2.8   0.0      0.49   8.7e+03      49      61 ..     163     175 ..     159     179 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 1.8e-05
                HHHHC-SS.S-CCHHHHHHHHHHHHHHHHHSSS-HHHH CS
        YvfG 14 eyieqneayedkiqalnaYYkvvvssllaDrlaknavl 51
                + ++  ++y++k+  ++a    + +s++ D++ kn  +
  EFC36854.1 27 NEVKVCRSYMNKLGTIDACTANIGGSIMIDQIKKNHTV 64
                5567789****************************766 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.49
                 HHHHHHHHHHHHH CS
        YvfG  49 avllkRirhLeea 61 
                  +ll+R + +eea
  EFC36854.1 163 LDLLRRRKTIEEA 175
                 5899999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (364 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1355  (0.0755759); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2354.18
//
Query:       EFC36855.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1153  (0.0643092); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 3133.85
//
Query:       EFC36856.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-22   78.7   0.6    2.8e-09   36.6   0.2    3.3  3  D123      D123
    9.6e-06   25.5   0.2     0.0089   15.9   0.1    2.8  2  R2K_2     ATP-grasp domain, R2K clade family 2
    0.00065   19.8   0.0     0.0033   17.5   0.0    1.9  1  R2K_3     ATP-grasp domain, R2K clade family 3


Domain annotation for each model (and alignments):
>> D123  D123
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.0   0.00062       3.7       1     109 [.      18     117 ..      18     133 .. 0.59
   2 !   36.6   0.2   4.6e-13   2.8e-09     111     186 ..     154     224 ..     149     231 .. 0.89
   3 !   32.6   0.0   7.8e-12   4.7e-08     213     280 ..     228     298 ..     225     314 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.00062
                 HHHHHGGGS--EEEES--HHHHHHHCSSSEE-----...............--------------------...HHHHHHHHHHHHHT....TS-EEEE CS
        D123   1 WypkfrkltikskiiplpeefleYLeedgivlpeeseeekesaeesesdsdseesdsedeeeeeeeeeepseefpeleekikeaieel....ggavfpK 95 
                 Wy+   +lt+++++i+l+ee +  +  d+ +++ e ++e          ++s  +  ++ +++++     ++ +++le ++++ ++el    ++ +f+K
  EFC36856.1  18 WYDAIVDLTFRTRMISLSEEQIMAIILDNEYFNGECNQE--------VLETSGIDIVSSLNSDTR-----RTVLETLEIDVNREMKELsccnDEGCFIK 103
                 777777778888888887777765555555555444332........222222222222222222.....2456677777777777763333688**** PP

                 -SS---GGGCCTSS CS
        D123  96 lnwsaPkDAawila 109
                 l   +PkDA  + a
  EFC36856.1 104 LSCRSPKDAFAVCA 117
                 *********76654 PP

  == domain 2  score: 36.6 bits;  conditional E-value: 4.6e-13
                 SSS-BSSHHHHHHHHHT-HHHHHHHHHTTTTBT--TTS-S-TT----EEEEE-----GGGEEEEEEETTEEEEEEE CS
        D123 111 nslkctsvndvylLLksSdfiahDLehafdeceeeeeesekeeieleLvLrkwfdlnpslefRcFVkdrkLiaisq 186
                 +s+k++++++ y  +  S  + +DL   f +     +++++ee ++++++r+w+d+  ++efR FVk+++L aisq
  EFC36856.1 154 QSMKVKDFAEEYTYFTKSARVLEDL-LLFLKY----DKKQREENPIKIIIREWVDIPSKYEFRSFVKNKQLTAISQ 224
                 689**********************.566555....6777788899*****************************9 PP

  == domain 3  score: 32.6 bits;  conditional E-value: 7.8e-12
                 ..TTTSSSSSEEEEEEEETT..EEEEEEEEESSTTS--TTS-HHH....HH.....HS-TTSSS-EEE---- CS
        D123 213 klkekfpdesyvfDvyvpkkldkvkliDinpfaertdslLFtwee....Lleeeeeeeeeeeeepelrlves 280
                 ++++++p ++y+ D  ++++ ++v+++ +npf+++td++LF+w++    L+  + ++e+++ +++e+rl ++
  EFC36856.1 228 TFAHRVPLNDYICDFAIDSN-GRVYIVELNPFSTTTDACLFSWTKdgeiLNGIQIKNETNQLDQIEFRLKKE 298
                 56788999***********9.**********************85444455667778888899999999633 PP

>> R2K_2  ATP-grasp domain, R2K clade family 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       0.2   1.2e+03      52      74 ..     150     172 ..      95     176 .. 0.65
   2 !   15.9   0.1   1.5e-06    0.0089      46      88 ..     184     231 ..     149     264 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.2
       R2K_2  52 dlpvlvsevvsfasEyRlfvldg 74 
                 +  + + +v +fa+Ey  f    
  EFC36856.1 150 ESFIQSMKVKDFAEEYTYFTKSA 172
                 33344556667899988876655 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 1.5e-06
       R2K_2  46 l...gsldedlpvlvsevvsf..asEyRlfvldgeiitvsrYagegrl 88 
                     +++++++++++ e v++  + E+R fv ++++ ++s+Y +   +
  EFC36856.1 184 YdkkQREENPIKIIIREWVDIpsKYEFRSFVKNKQLTAISQYFDTFAH 231
                 344488999999*****99998899*****************664433 PP

>> R2K_3  ATP-grasp domain, R2K clade family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   5.5e-07    0.0033      75     184 ..     161     258 ..     136     261 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 5.5e-07
       R2K_3  75 FvkprgdklfggvVlrefeelralaakle...dtevlvsevvrf..saEwRvFvvdGevvaasrYrkanddpdlepdlaafaeavralvgappfyvlDv 168
                 F+++   ++ +++Vl+++  + + ++k++    +++++ e+v++    E+R Fv ++++ a+s+Y               f++ +++++  ++ y  D+
  EFC36856.1 161 FAEEYTYFTKSARVLEDLLLFLKYDKKQReenPIKIIIREWVDIpsKYEFRSFVKNKQLTAISQY---------------FDTFAHRVP--LNDYICDF 242
                 666666666667777666666655555445569999*****9554499*****************...............444555677..888***** PP

       R2K_3 169 avtadGrwkVVEvndg 184
                 a +++Gr ++VE+n +
  EFC36856.1 243 AIDSNGRVYIVELNPF 258
                 **************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       915  (0.0510346); expected 358.6 (0.02)
Passed bias filter:                      519  (0.0289475); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2047.04
//
Query:       EFC36857.1  [L=170]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-17   63.8   0.0    1.8e-17   63.5   0.0    1.1  1  Ras       Ras family
      4e-08   33.5   0.1    5.5e-08   33.0   0.1    1.3  1  Roc       Ras of Complex, Roc, domain of DAPkinase
    4.4e-06   26.3   0.0    6.2e-06   25.8   0.0    1.3  1  Arf       ADP-ribosylation factor family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.5   0.0   2.9e-21   1.8e-17      21     146 ..       3     145 ..       1     156 [. 0.82

  Alignments for each domain:
  == domain 1  score: 63.5 bits;  conditional E-value: 2.9e-21
                 HSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHST..........TTSEEEE CS
         Ras  21 kdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrvae..........envpivL 109
                 +++F++ y++Tig d  + + ++++k  +++ wDT Gqe+fk ++++  ++a+    ++++++ +sfe++k+ +++ k+             +n  +++
  EFC36857.1   3 RENFTDFYIPTIGLDTCSCRYRYQNKLFHFNTWDTSGQERFKFVNSTLHSKAKINCFCFSLNDYSSFERCKENYNDWKKRNAnykvmeylenHNGCVLI 101
                 578********************************************************************7777766655557788899877778999 PP

                 EEETTTGGG.......G-SS-HHHHHHHHHHHTSEEEEEBTTTT CS
         Ras 110 vGnKvDlee.......kravsteegeelakelglkfletSAktn 146
                 +G K+Dle+       k+ +  e ++    ++ ++++  S k++
  EFC36857.1 102 LGLKSDLEQkvpsqeiKELLLVEPANCRLYSNRVQYFALSSKND 145
                 9*******855544444444444444444777788888888765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.0   0.1   9.2e-12   5.5e-08      21     112 ..       3      89 ..       1     109 [. 0.75

  Alignments for each domain:
  == domain 1  score: 33.0 bits;  conditional E-value: 9.2e-12
                 T-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHHHHHHHHHHHCSSS-EE CS
         Roc  21 edkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlkeWlkelkkvagkspvi 112
                 +++f++ + +tig+d+++ ++     +  +   k +++n WDt+Gqerf+ +++   ++a++ ++++     +s+e+ ke +++ kk++ + +v+
  EFC36857.1   3 RENFTDFYIPTIGLDTCSCRYR----Y--Q--NKLFHFNTWDTSGQERFKFVNSTLHSKAKINCFCFSlndYSSFERCKENYNDWKKRNANYKVM 89 
                 5789999*********997752....2..2..25699************************9999986444445566666666666666555544 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.0     1e-09   6.2e-06      42     144 ..      10     125 ..       1     147 [. 0.78

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 1e-09
                 CSSSSSEEEEEEEE....TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHH.........HHCTSGCCTTSEEEEEEE-TTS CS
         Arf  42 tvPTigfnveelei....knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLk.........alleeeelkevallvlaNKqDl 127
                  +PTig ++ + ++    k ++f++wD  Gqe+ + + ++  +k +   f+   +d + +e +ke+ +         +++e  e+++  +l+l+ K Dl
  EFC36857.1  10 YIPTIGLDTCSCRYryqnKLFHFNTWDTSGQERFKFVNSTLHSKAKINCFCFSLNDYSSFERCKENYNdwkkrnanyKVMEYLENHNGCVLILGLKSDL 108
                 68****9999998866667799********************99999999998888777777777665111222222466666777999********** PP

                 TTSS-HHHHHHHTTGGG CS
         Arf 128 pealseeelrellglee 144
                 ++ + ++e++ell +e 
  EFC36857.1 109 EQKVPSQEIKELLLVEP 125
                 ***********997765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       569  (0.0317363); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1115.60
//
Query:       EFC36858.1  [L=527]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-21   76.8   4.8    9.1e-21   74.4   1.6    2.2  2  Pkinase         Protein kinase domain
    2.1e-08   33.8   0.1    3.9e-08   32.9   0.1    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
  ------ inclusion threshold ------
      0.062   13.2   0.0       0.15   12.0   0.0    1.6  2  APH             Phosphotransferase enzyme family
       0.14   10.9   2.2       0.13   11.0   0.5    1.6  2  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.4   1.6     2e-24   9.1e-21      56     258 ..      29     242 ..       1     244 [. 0.75
   2 !    3.5   0.1    0.0086        39     231     260 ..     368     412 ..     285     414 .. 0.60

  Alignments for each domain:
  == domain 1  score: 74.4 bits;  conditional E-value: 2e-24
                 SCTTB--EEEEEEE.....SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEET....TTE......EE CS
     Pkinase  56 khpnivrlyevfee.....kdelylvleyveggeladllerkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLide....kge......lK 138
                 + ++i +++  ++      ++++++ + y egg+l +       +s + + ++ kq+++gl+ +H ++++iHrD+K +Ni +d+    + +      +K
  EFC36858.1  29 QFEHIAQFKTLIKAkddpnDTSYFMTTKYYEGGTLGNTK---YGFSFNFVISVGKQLVQGLKDIHmKMSLIHRDIKLDNIALDQvvveN-NeiqsaiIK 123
                 3677777777777666676778889********776655...57*********************9999**************766652.1567778** PP

                 E-SGTTSEESSSSCS..BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS. CS
     Pkinase 139 itDFGlakelesssk..ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasei. 233
                 ++DF  a  ++++     + + +t+ Y+ P  +     s+k+ +++lG+il+ +l+g+   +   ++ +v+++++  +  ++ ++   +++++ +++i 
  EFC36858.1 124 VIDFESAVSIQNQGAleEEMYHATKSYRCPDDI---LLSTKSEIYALGLILFRMLYGTYGER---DELHVSQNFKGQQDYTEQMKkSLDVNTRLHRTIm 216
                 ************99977778899*******988...689******************97666...3333444444423333322224445555555554 PP

                 .-HHHHHHHHHHT-SSGCCSTTHHHH CS
     Pkinase 234 .seeakdllkkllkkdpkkRltaeel 258
                  +  +k+llk++l+++p++R+  +e+
  EFC36858.1 217 dDCRMKRLLKRMLSYNPHQRPELDEI 242
                 477889***************88775 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.0086
                 TTS...............-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 231 sei...............seeakdllkkllkkdpkkRltaeellq 260
                 +++               ++e++d++++ l+++p+   ta+++lq
  EFC36858.1 368 QNLsrvnklfekqrknknPKEILDMVNENLEVNPNLKKTASDILQ 412
                 2223333445555555559*********************99987 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.9   0.1   8.6e-12   3.9e-08      60     256 ..      30     243 ..       7     246 .. 0.79

  Alignments for each domain:
  == domain 1  score: 32.9 bits;  conditional E-value: 8.6e-12
                  BTTB--EEEEEE.....SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE.........TTEE CS
  Pkinase_Tyr  60 hpnivkllgvct.....keepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse.........nkvv 142
                   ++i ++  ++      ++ ++++ t+y +gG+L +     +k  ++++ ++s+  q+ +G++ ++ k +l+Hrd+   N+ l++         + ++
   EFC36858.1  30 FEHIAQFKTLIKakddpNDTSYFMTTKYYEGGTLGN-----TKYGFSFNFVISVGKQLVQGLKDIHMKmSLIHRDIKLDNIALDQvvvenneiqSAII 122
                  566666666666533323334788888888888875.....367899999*************99965279*************999999999889** PP

                  EE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHH..TTSSGT.......TTTS..HHHHHHHHHHTTEES-BBTT CS
  Pkinase_Tyr 143 kisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEif..tlgesp.......ypgl..kneevleklkegkrlekpek 229
                  k+ Df  a +i+++    ++e  +    +  p   ++  +++ks +++ G +l+ ++  t+ge+        ++g    +e++ + l+ ++rl++   
   EFC36858.1 123 KVIDFESAVSIQNQGA-LEEEMYHATKSYRCP---DDILLSTKSEIYALGLILFRMLygTYGERDelhvsqnFKGQqdYTEQMKKSLDVNTRLHRTIM 216
                  ***********54444.445555566666666...56689****************94456776678887774444224567889999999***9999 PP

                  SBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 230 cpeelyelmkkcweedpeeRptfselv 256
                     ++++l+k+ ++++p++Rp++ e+ 
   EFC36858.1 217 DDCRMKRLLKRMLSYNPHQRPELDEID 243
                  999*******************99985 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   3.2e-05      0.15     162     196 ..      85     130 ..      17     133 .. 0.82
   2 ?   -3.0   0.0       1.2   5.6e+03      92     123 ..     198     229 ..     172     241 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3.2e-05
                 S....SS-EEEE-SS-SGGGEEEC.........TTEEEEE---TT- CS
         APH 162 g....elptvllHgDlhpgNllvd.......pddgrvtGviDfeda 196
                 g    + +++l+H+D++++N+ +d       + +  ++ viDfe a
  EFC36858.1  85 GlkdiHMKMSLIHRDIKLDNIALDqvvvennEIQSAIIKVIDFESA 130
                 444557899***************9997554334444668899977 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHCCHHCH.-STTTB-SHHCHTC CS
         APH  92 pellealgeflaalhqvdpaalpladflaqdl 123
                  e+  +  ++  +lh++ ++++++ + l++ l
  EFC36858.1 198 TEQMKKSLDVNTRLHRTIMDDCRMKRLLKRML 229
                 45666677788889998888888877776655 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.5   2.9e-05      0.13     314     365 ..      81     136 ..      73     151 .. 0.76
   2 ?   -2.2   0.0       0.3   1.4e+03     209     240 ..     189     221 ..     184     253 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 2.9e-05
  Pkinase_fungal 314 DaIkghrsLflkagiLHrDiSenNilitds.kke...gerkglLiDLDlakelsdd 365
                     + ++g++  + k  ++HrDi  +Ni + +   ++   ++    +iD++ a++++++
      EFC36858.1  81 QLVQGLKDIHMKMSLIHRDIKLDNIALDQVvVENneiQSAIIKVIDFESAVSIQNQ 136
                     568999*******************99855422234477777889***99999863 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.3
  Pkinase_fungal 209 edveekdddiaeiRkgldvtka.ekfrskrkvv 240
                     ++ ++++d +++++k+ldv+++ ++    ++ +
      EFC36858.1 189 QNFKGQQDYTEQMKKSLDVNTRlHRTIMDDCRM 221
                     445578888899999999999866544444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (527 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1063  (0.0592894); expected 358.6 (0.02)
Passed bias filter:                      572  (0.0319036); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 2941.90
//
Query:       EFC36859.1  [L=782]
Description: elongation factor G, domain IV [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.7e-23   80.8   0.0      2e-22   79.3   0.0    1.9  1  EFG_IV       Elongation factor G, domain IV
    9.7e-18   64.4   0.0    1.8e-17   63.6   0.0    1.4  1  GTP_EFTU     Elongation factor Tu GTP binding domain
      8e-09   35.6   0.0    2.1e-08   34.3   0.0    1.8  1  MMR_HSR1     50S ribosome-binding GTPase
    9.4e-07   28.8   0.0    2.4e-06   27.5   0.0    1.7  1  EFG_II       Elongation Factor G, domain II
    1.1e-06   28.6   0.0    6.4e-06   26.1   0.0    2.2  2  EFG_C        Elongation factor G C-terminus
      8e-05   22.8   0.0    0.00016   21.9   0.0    1.5  1  Roc          Ras of Complex, Roc, domain of DAPkinase
     0.0066   16.8   0.0      0.014   15.7   0.0    1.6  1  GTP_EFTU_D2  Elongation factor Tu domain 2
  ------ inclusion threshold ------
      0.012   15.3   0.0      0.027   14.1   0.0    1.6  1  Ras          Ras family
      0.071   13.4   0.0       0.25   11.7   0.0    2.1  1  DUF5461      Family of unknown function (DUF5461)
      0.077   13.5   0.0       0.26   11.8   0.0    1.8  1  ABC_tran     ABC transporter
      0.084   13.6   0.8        3.4    8.5   0.0    2.9  2  RecG_N       RecG N-terminal helical domain
       0.13   12.5   0.0       0.47   10.7   0.0    1.9  2  AAA_22       AAA domain
       0.17   11.4   0.0       0.48    9.9   0.0    1.7  1  CBP_BcsR     Cellulose biosynthesis protein BcsR
       0.18   11.7   1.7         20    5.0   0.1    2.9  3  RsgA_GTPase  RsgA GTPase


Domain annotation for each model (and alignments):
>> EFG_IV  Elongation factor G, domain IV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.3   0.0   1.5e-25     2e-22      12     120 ..     563     670 ..     552     671 .. 0.95

  Alignments for each domain:
  == domain 1  score: 79.3 bits;  conditional E-value: 1.5e-25
                 -CCHCCCCCCCHTSSSHCCCCCEEEECCTTTTSSEEEEE--STCCCHCCCCHHHHCCCCCCTTS-TTTS--EESEEEEEEEEE--T..TTC-HHHHHHH CS
      EFG_IV  12 pvkereeklkkqsggdgqyakvileiePleegsgnefvdetkggqvpkeyieavekGfqealkeGplagepvtdvkvtLldgslhe..vdsseaafkpa 108
                 + k+r ++l+++ g+d  +ak+i+++ +   +s n+fvd+t+++ +++e+++av  Gf+ a++eGpl++e +++v+++L d+++++  ++++ +++ p+
  EFC36859.1 563 EPKQRGKILNENFGWDLVDAKKIWSLCE---NSLNVFVDKTQQVCYLNEIKDAVILGFHIATREGPLCNELMRGVRFNLKDVAMYSdaIHRGTGQIAPT 658
                 456799**********************...57****************************************************99************ PP

                 HCHHHHHHHHCC CS
      EFG_IV 109 arralkeallkA 120
                 ++r++++++l+A
  EFC36859.1 659 VKRGCYASVLDA 670
                 ********9998 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.6   0.0   1.4e-20   1.8e-17       2     183 ..       2     197 ..       1     283 [. 0.78

  Alignments for each domain:
  == domain 1  score: 63.6 bits;  conditional E-value: 1.4e-20
                 CEEEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHHHHHSTHCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEE CS
    GTP_EFTU   2 rirnigiighvDhGKtTLtdrLlyktgaiskkgekaeeervlDtlkeErergiTiksaaisleketkkylinliDtPGHvdFskevirglrvlDgavlv 100
                 +irn++i+g   +GK++L+  L+ +++++++       +++l  + + +    + k +  +    + +  +nl+D+ G  +  ++v + lr +Dg+++v
  EFC36859.1   2 SIRNVAICGEPSSGKSSLVHLLINNNHQTNS-------TQILFETFQSQLYSTSLKLNSHHDV--EVNSILNLVDCIGRLESLSQVKADLRLTDGCIMV 91 
                 59*****************999977777666.......3468888888888888888877766..79999***************************** PP

                 EETTTB.STHHHHHHHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHHHHH....HHHHHHHHHTTT...TTEEEEEEBTTTTBTHH......... CS
    GTP_EFTU 101 vdaveG.vepqteevlrlalkegvpiivfiNKmDrlkaelkeiveevkqklsrk....eeklekygekge...kevpvvfgSalkgegvk......... 182
                 vda+       +e vlr++++e++p++v+ NK+D++  +++   ee++++++r     +  ++ + +  e   +  ++vfgS ++g++++         
  EFC36859.1  92 VDASLPtFGKYSELVLRQISQENIPLVVLFNKLDEPLMDCNVDLEEINKSIQRIvdsvNLVMSTFNT--EsklSLESIVFGSTKQGWAFTlkhfamfys 188
                 ***96537888999**********************5555555555555554442222444444433..23358899**********887555555555 PP

                 ........H CS
    GTP_EFTU 183 ........t 183
                         +
  EFC36859.1 189 kqfgmnqdE 197
                 555555553 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.3   0.0   1.6e-11   2.1e-08       1     114 []       5     123 ..       5     123 .. 0.76

  Alignments for each domain:
  == domain 1  score: 34.3 bits;  conditional E-value: 1.6e-11
                 EEEEEESTTSSHHHHHHHHHTS..TEEESSSTTSSSSEEEEEEEETTEE.........EEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.. CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltge..kaivsdkpgtTrdinegrvklkgke.........ielvDtpGliegaseekglgkaflaleeadlillvvdas.. 86 
                 +vai G p +GKS+L+  l+++  +   +++ + T + + +  +lk ++         ++lvD+ G +e      +l++  ++l+ +d  ++vvdas  
  EFC36859.1   5 NVAICGEPSSGKSSLVHLLINNnhQTNSTQILFETFQSQLYSTSLKLNShhdvevnsiLNLVDCIGRLE------SLSQVKADLRLTDGCIMVVDASlp 97 
                 59*******************96567889999*******99988443223445555559*******777......677777766679********9965 PP

                 .TTCSHHHHHHHHHHHHHTTSEEEEEEES CS
    MMR_HSR1  87 .eeklkpldeeleelleeakkplilvlnk 114
                   +k+    e + + ++++++pl++++nk
  EFC36859.1  98 tFGKY---SELVLRQISQENIPLVVLFNK 123
                 42234...333444445678999999998 PP

>> EFG_II  Elongation Factor G, domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.0   1.9e-09   2.4e-06       4      65 ..     440     501 ..     438     510 .. 0.95

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 1.9e-09
      EFG_II   4 PvislaiepkskadedklskaLarlleEDptlrverdeeTketilsGmGelHleivverlkr 65 
                 P+i++ +epk++a   kl + L+ + + D +l+++ de T+e il+   e Hl+ v+ + k+
  EFC36859.1 440 PMINVYVEPKKQAYLPKLIRGLELIYKCDSSLSFTLDEYTGEKILTVFDEKHLDSVLHQFKQ 501
                 9*****************************************************99988876 PP

>> EFG_C  Elongation factor G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.4   1.8e+03       2      24 ..     124     148 ..     123     162 .. 0.75
   2 !   26.1   0.0     5e-09   6.4e-06       2      84 ..     674     751 ..     673     754 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.4
                 EEEEEEEEEEEEE..CCCCCCHHHH CS
       EFG_C   2 llEPivkveievp..eeyvgkvisd 24 
                 l EP+++++++ +  ++ +++++++
  EFC36859.1 124 LDEPLMDCNVDLEeiNKSIQRIVDS 148
                 569*******998455666666655 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 5e-09
                 EEEEEEEEEEEEECCCCCCHHHHHHHCT-EEEEEEEE.TTEEEEEEEEEGGG-TTHHHCHHHCTTTS-EEEEEEEEEEE--HH CS
       EFG_C   2 llEPivkveievpeeyvgkvisdlssrrGeiedmeqdasgrviieaeiPlaeligfateLrslTkGegsfsmefsgYeevpgd 84 
                 llEPi  +e ++ ++ +++v+s l+srrG +++ +++  + v  +a +P++e++g  + L ++   + s +  f++++++p +
  EFC36859.1 674 LLEPISLMEFKCKKSELSAVYSILNSRRGVVIEEQHT--SSVFGKAFLPVSESFGVLQYLDQY---NVSSQFIFDHWQPIPAN 751
                 8*******************************99998..99999***********99999877...67888888888888875 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.0   1.3e-07   0.00016       2     120 .]       6     126 ..       5     126 .. 0.72

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 1.3e-07
                 EEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTT.CEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHHHH CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvk.kvklniWDtaGqerfrslhplylreaalailvydsrssenlkeWl 99 
                 v ++G+ ++GK+sl++ +++++ ++++++++  +f ++ +++  +++++++v+ +  ln+ D  G  +  s  +  lr  + +i+v+d++  +  k+  
  EFC36859.1   6 VAICGEPSSGKSSLVHLLINNNHQTNSTQILFETFQSQLYSTSLKLNSHHDVEvNSILNLVDCIGRLESLSQVKADLRLTDGCIMVVDASLPTFGKYSE 104
                 789*******************999998877777766555444444444444314669*******9888888888899999999999976443333333 PP

                 HHHHHHC.SSS-EEEEEE-TTT CS
         Roc 100 kelkkva.gkspvilvgnkiDl 120
                   l++ + +++p++++ nk+D+
  EFC36859.1 105 LVLRQISqENIPLVVLFNKLDE 126
                 33444430578999999**995 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   1.1e-05     0.014       6      74 .]     352     421 ..     349     421 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.1e-05
                  EEEEESEEETTEEEEEECTCTTSEEEEEEEEEEEEETEEESEEETTSEEEE..EEEESSCCS..GSSTTCEEE CS
  GTP_EFTU_D2   6 grvysGtlkkGdevrilgndtskkeivtrissletfhededeavaganaGv..ivaikgled..aiivGdtlt 74 
                   r++sG lk +  vr+    +++ ++    +++ + ++   e++++a + +  i++++g+e+  +  +G+t+t
   EFC36859.1 352 SRIFSGSLKSDTIVRV--FNSKQVFEEKSLRGIVKINGTSIEPIEEASCQFnpIIGLIGIESclT-NKGSTIT 421
                  69**************..777666788********************999877899999999877.8999986 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   2.1e-05     0.027       2     116 ..       6     126 ..       5     152 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.1e-05
                 EEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEET..........TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTH CS
         Ras   2 lvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievd..........gkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenv 90 
                 + + G+ + GK+sl++  ++++ ++++++ + ++ +++++             + +  l++ D  G  e  s  ++ +r ++g+++v d    +s+ + 
  EFC36859.1   6 VAICGEPSSGKSSLVHLLINNNHQTNSTQIL-FETFQSQLYSTslklnshhdvEVNSILNLVDCIGRLESLSQVKADLRLTDGCIMVVD----ASLPTF 99 
                 6789********************9998877.665554444444556687766666779*******98888888889999999999987....455555 PP

                 HHHHHHHHHHST.TTSEEEEEEETTTG CS
         Ras  91 kkwveeikrvae.envpivLvGnKvDl 116
                  k+ e + r+ + en+p+v++ nK D 
  EFC36859.1 100 GKYSELVLRQISqENIPLVVLFNKLDE 126
                 5555555555554899********995 PP

>> DUF5461  Family of unknown function (DUF5461)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0    0.0002      0.25      28      91 ..     395     461 ..     362     463 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.0002
     DUF5461  28 eedvkkdyiigrvgiirisktyiGivlvdGvki...pfvaevhln.nkidiyldprkdfylallvGel 91 
                 e + + + iig +gi+    t  G  +++  ++   pf+++   n   i++y++p+k+ yl +l+  l
  EFC36859.1 395 EASCQFNPIIGLIGIESC-LTNKGSTITESTELeakPFISDSKSNlPMINVYVEPKKQAYLPKLIRGL 461
                 456667779999998754.45566666666654445*******994579*************999765 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0    0.0002      0.26      13      45 ..       5      38 ..       3      83 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.0002
                EEEEEESTTSSHHHHHHHHTTSS--SEE.EEEET CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxx RF
    ABC_tran 13 kvaivGenGaGKStLlkllagllkpteG.eilld 45
                 vai Ge  +GKS+L+ ll+++ ++t+  +il++
  EFC36859.1  5 NVAICGEPSSGKSSLVHLLINNNHQTNStQILFE 38
                69****************9999888654145444 PP

>> RecG_N  RecG N-terminal helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0    0.0026       3.4      16      81 ..      26      91 ..      18      93 .. 0.90
   2 ?    2.2   0.3      0.24   3.1e+02       2      33 ..     251     282 ..     245     297 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0026
                ---TTT........HHHHHHH---GGGG-HHHH.HHHHHHHHHHTTSSSS-HHHHHHHHHHHHHHH CS
      RecG_N 16 vlsgkleteelieeikkkleliddplleneevlkeklskfldYikpiasLpeeRkikRlknglemi 81
                  ++  +t+ l+e ++++l     +l ++++v+ + + +++d i +++sL++ ++  Rl  g  m+
  EFC36859.1 26 NNHQTNSTQILFETFQSQLYSTSLKLNSHHDVEVNSILNLVDCIGRLESLSQVKADLRLTDGCIMV 91
                4566677899**************************************************999998 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.24
                 HHHHHHHHHHHHTS---TTT........HHHH CS
      RecG_N   2 iEeFLeelekllkkvlsgkleteelieeikkk 33 
                 +Ee L+ + k+l k + + l+ +eli+   +k
  EFC36859.1 251 LEEVLNPFVKSLSKTEYTDLSKQELINSTMQK 282
                 79999999999999999999999999876554 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00037      0.47       8      48 ..       6      40 ..       3      93 .. 0.77
   2 ?   -2.2   0.0       3.7   4.8e+03      54      90 ..     252     288 ..     224     295 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00037
      AAA_22  8 lvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlp 48
                ++++Ge+ +GK+ l+  l +++++       ++++++++  
  EFC36859.1  6 VAICGEPSSGKSSLVHLLINNNHQT------NSTQILFETF 40
                68********************987......5555544444 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 3.7
      AAA_22  54 kdllrellralglelkaerlsseell.ealeqalrara 90 
                 +++l+ +++ l        ls++el+ +++++ l+a  
  EFC36859.1 252 EEVLNPFVKSLSKTEY-TDLSKQELInSTMQKWLSANN 288
                 3444444444444444.488999999888888777655 PP

>> CBP_BcsR  Cellulose biosynthesis protein BcsR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00038      0.48      13      35 ..     261     283 ..     248     283 .. 0.93

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00038
    CBP_BcsR  13 slpelrYiDIareerlasalaRW 35 
                 sl++ +Y+D +++e  +s +++W
  EFC36859.1 261 SLSKTEYTDLSKQELINSTMQKW 283
                 8999******************* PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.1     0.016        20     102     127 ..       6      30 ..       1      39 [. 0.81
   2 ?   -1.5   0.0       1.6   2.1e+03      29      82 ..      39      92 ..      33     105 .. 0.82
   3 ?    4.9   0.1     0.017        22      37      77 ..     105     147 ..      71     174 .. 0.69

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.016
                  EEEECSTTSSHHHHHHHHCTT----- CS
  RsgA_GTPase 102 svlvGqSGvGKStLinallpelelkt 127
                  ++++G+   GKS+L+  l++++++ t
   EFC36859.1   6 VAICGEPSSGKSSLVHLLINNNHQ-T 30 
                  7899**9***********998544.3 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.6
                 T--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE- CS
  RsgA_GTPase 29 elslnlldrfLvlaeekgiepvivlnKiDlleeeeeleelkeelealgyevllv 82
                 +++++l +  L l  ++++e+  +ln +D++ + e+l+++k++l+ ++  +++v
   EFC36859.1 39 TFQSQLYSTSLKLNSHHDVEVNSILNLVDCIGRLESLSQVKADLRLTDGCIMVV 92
                 56777777888889999999999********99999999999988776655555 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.017
                  HHHHHHHHTT-EEEEEEE-GG..G--HHHHHHHHHHHHHHTTS CS
  RsgA_GTPase  37 rfLvlaeekgiepvivlnKiD..lleeeeeleelkeelealgy 77 
                   +L ++ +++i++v+++nK+D  l++ + +lee+++ ++++  
   EFC36859.1 105 LVLRQISQENIPLVVLFNKLDepLMDCNVDLEEINKSIQRIVD 147
                  5788999*************94434444467777777766632 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (782 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       734  (0.0409393); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.81u 0.30s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 4504.79
//
Query:       EFC36860.1  [L=373]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.011   16.1   1.6      0.019   15.4   1.6    1.3  1  Notch          LNR domain
       0.12   12.5   1.3       0.27   11.4   1.3    1.5  1  Cys_rich_FGFR  Cysteine rich repeat


Domain annotation for each model (and alignments):
>> Notch  LNR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   1.6   2.1e-06     0.019       4      24 ..     181     201 ..     179     204 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.1e-06
       Notch   4 CsaeeyCaekfgdgvCDeeCn 24 
                 C+  + C++ f+d++CD+ C 
  EFC36860.1 181 CELLKICEDEFNDKYCDKTCT 201
                 887789**************7 PP

>> Cys_rich_FGFR  Cysteine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   1.3     3e-05      0.27       9      39 ..     168     199 ..     165     211 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3e-05
  Cys_rich_FGFR   9 rlqeevaeDykldpkLqkaCkddiek.fCsdi 39 
                    ++ + v++++++ ++L+k C+d+++  +C+++
     EFC36860.1 168 ERIKLVERNVRIACELLKICEDEFNDkYCDKT 199
                    677899******************667**985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (373 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       492  (0.0274416); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 2355.50
//
Query:       EFC36861.1  [L=220]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       387  (0.0215851); expected 358.6 (0.02)
Passed bias filter:                      284  (0.0158403); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1443.73
//
Query:       EFC36862.1  [L=277]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.1e-59  198.3   0.2    6.9e-59  197.9   0.2    1.2  1  DUF1445   Protein of unknown function (DUF1445)


Domain annotation for each model (and alignments):
>> DUF1445  Protein of unknown function (DUF1445)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  197.9   0.2   3.8e-63   6.9e-59       1     143 []     114     261 ..     114     261 .. 0.98

  Alignments for each domain:
  == domain 1  score: 197.9 bits;  conditional E-value: 3.8e-63
     DUF1445   1 VaFliGcSfsfeeaLleaglpvrhveqgrnvpmYktniplapagvf.....sgklvvsmrpikkekvervveitrrfkkvhgePvhigdpealgikdls 94 
                 V+FliGcSfsfe+aL+++g+++r+++++rnv+mYktni ++++ +f     s ++vvsmrp+k+++ve + +it++f+++hg P+h+gdp+++gi+dls
  EFC36862.1 114 VTFLIGCSFSFEKALQAHGIEIRNITEKRNVSMYKTNILCKTQPNFkylnqSIPMVVSMRPVKPDQVELAKAITEQFTTTHGGPIHCGDPKEIGIEDLS 212
                 8*********************************************88776667********************************************* PP

     DUF1445  95 kpdyGdaveieegevPvFWacgvtpqeavmsaklelvithapghmlvtD 143
                 k+d+Gd+v+++++e+P+FWacgvt+ +a  +++++++ithapg+m++ D
  EFC36862.1 213 KVDFGDSVTVHQDEIPCFWACGVTSSMAALAIESDICITHAPGNMFISD 261
                 ***********************************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       388  (0.0216409); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.43
# Mc/sec: 1944.39
//
Query:       EFC36863.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00017   21.4   2.3    0.00057   19.7   0.1    2.9  3  F-box-like  F-box-like
    0.00029   20.6   0.1    0.00086   19.1   0.1    1.8  1  F-box       F-box domain
  ------ inclusion threshold ------
       0.11   12.1   0.1        0.4   10.3   0.1    2.0  1  F-box_5     F-box
       0.13   12.4   0.0       0.41   10.8   0.0    1.8  1  DUF5641     Family of unknown function (DUF5641)


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.1   1.3e-07   0.00057      10      43 ..      10      42 ..       7      46 .. 0.82
   2 ?   -0.7   0.1      0.31   1.4e+03      23      42 ..     229     246 ..     214     248 .. 0.72
   3 ?   -2.4   0.0         1   4.7e+03      33      44 ..     490     501 ..     487     503 .. 0.79

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 1.3e-07
  F-box-like 10 lqIFsyLppsdLlrlalVCrrWrrvaldtplLWr 43
                  + +yLp+ dL+++ lVC+ W+++ + +  +W+
  EFC36863.1 10 FCVMEYLPLHDLSNALLVCKEWHSLDQYE-PFWK 42
                55789******************995555.5665 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.31
  F-box-like  23 rlalVCrrWrrvaldtplLW 42 
                 rl   +++W ++ + +  L+
  EFC36863.1 229 RLDNASKYWEQILN-C-CLY 246
                 666779*****975.4.576 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 1
  F-box-like  33 rvaldtplLWrr 44 
                 +v+ ++ ++Wrr
  EFC36863.1 490 EVTENPDSIWRR 501
                 57788899**99 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.1   1.9e-07   0.00086       5      36 ..       3      34 ..       1      44 [. 0.93

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 1.9e-07
                HS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHH CS
       F-box  5 rLPsevlrhILerLplsdllalrrVSkgwril 36
                +L+++ l  ++e+Lpl dl ++ +V+k w++l
  EFC36863.1  3 NLSLDELFCVMEYLPLHDLSNALLVCKEWHSL 34
                8999*************************995 PP

>> F-box_5  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.1     9e-05       0.4      11      37 ..      11      36 ..       6      37 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 9e-05
                HHHCC---HHHHHHHTTS-HHHHHHHH CS
     F-box_5 11 cVlpyitsprDRnAvSlVCkrWYeiea 37
                cV++y+  + D + + lVCk+W+ +++
  EFC36863.1 11 CVMEYLPLH-DLSNALLVCKEWHSLDQ 36
                777777654.666677********995 PP

>> DUF5641  Family of unknown function (DUF5641)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   9.2e-05      0.41      39      75 ..      49      85 ..      32     101 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 9.2e-05
     DUF5641 39 kvgdlVlvkednlprlkWplgrvievhpgkDglvrvv 75
                  g+l+l+ ++ ++   W++g+v e+++g+D   ++ 
  EFC36863.1 49 LNGKLILLFDRMASNHLWNIGKVKETLKGNDVKSKYS 85
                5799***************************877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       844  (0.0470746); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 3663.64
//
Query:       EFC36864.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.033   14.9   0.4      0.033   14.9   0.4    2.2  2  Auxin_repressed  Dormancy/auxin associated protein
        7.1    6.2   9.5         15    5.1   9.5    1.5  1  SR-25            Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> Auxin_repressed  Dormancy/auxin associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.7      0.19   1.7e+03      34      63 ..      12      41 ..       3      61 .. 0.56
   2 ?   14.9   0.4   3.6e-06     0.033      37     115 ..      84     156 ..      66     161 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.19
  Auxin_repressed 34 gessdskyqrslsmpasagtpstPvtPtas 63
                      +s++s+++ s+s p  a + +   t t+s
       EFC36864.1 12 NSSASSTLNNSVSSPLHAVSATNHHTTTTS 41
                     445566777777777333333333333322 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 3.6e-06
  Auxin_repressed  37 sdskyqrslsmpasagtpstPvtPtassptsarkdnvWrsvfhPGsnlatkrlGaelfdkptpnsPtvydwlysgetrs 115
                      s ++yq s+    ++ tpstP+tP +  p+        r   +P s +  ++ G +l +k+  + P+v+d +++ + ++
       EFC36864.1  84 SLNNYQTSSPTLNVQLTPSTPTTPHS--PSH--LAHSPRNGKQPRSRM--QTTGIHLKEKVIEEIPSVFDVCFATDLKK 156
                      45678888777778889999999985..633..344568888898876..55788999**************9998765 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   9.5    0.0017        15      29     100 ..      11      82 ..       5      93 .. 0.67

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0017
       SR-25  29 rsssasksqsrkassasekeeerskekkkkkrrrssssssssssssssssssssssssdd.rkkrgkkkdkkk 100
                  +ssas++ +++ ss  ++     ++++  ++ +sss   +ss++  +s ss+s  ss++  k r   k+kk+
  EFC36864.1  11 VNSSASSTLNNSVSSPLHAV-SATNHHTTTTSFESSSNHCKSSTPFLDSFSSASMISSNElFKDRLDLKKKKQ 82 
                 46777777777776666544.5666666777777888888999998888777777666665555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1516.86
//
Query:       EFC36865.1  [L=589]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (589 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       924  (0.0515366); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.28s 00:00:00.94 Elapsed: 00:00:00.48
# Mc/sec: 3668.58
//
Query:       EFC36866.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.053   13.5   0.1      0.053   13.5   0.1    1.9  2  DUF1201   Protein of unknown function (DUF1201)


Domain annotation for each model (and alignments):
>> DUF1201  Protein of unknown function (DUF1201)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   2.9e-06     0.053      11      52 ..      10      52 ..       1      53 [. 0.85
   2 ?   -2.5   0.5      0.29   5.2e+03      23      33 ..     170     180 ..     163     186 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.9e-06
     DUF1201 11 lafG.fliclflfclvvfiwfvykqilfrttaqsnearhnhst 52
                l fG  li l+l  lv + ++  kq lfr       +rh  st
  EFC36866.1 10 LIFGtSLIILYLVGLVAWKYYDKKQRLFRKDILKRVSRHVNST 52
                4566259***********************9999999999887 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.29
     DUF1201  23 clvvfiwfvyk 33 
                 c+ ++ wf  k
  EFC36866.1 170 CFSIYAWFGIK 180
                 99999**9766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       517  (0.028836); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 2259.13
//
Query:       EFC36867.1  [L=616]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-11   43.8   1.9    4.8e-07   28.9   0.3    3.2  3  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.1   3.3e-05      0.59     281     305 ..     120     144 ..     116     159 .. 0.86
   2 !   28.9   0.3   2.7e-11   4.8e-07     317     390 ..     387     463 ..     379     473 .. 0.83
   3 !    3.5   0.0    0.0013        24     412     443 ..     555     585 ..     554     598 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 3.3e-05
                 HHHHHHHHHHHSHHHHHHHHHHHHH CS
        p450 281 tlswaLyeLaknPevqeklreEide 305
                  lsw++ +La+++++q+k+r+Ei +
  EFC36867.1 120 NLSWTICHLAQDQSLQDKVRKEIFQ 144
                 599*******************966 PP

  == domain 2  score: 28.9 bits;  conditional E-value: 2.7e-11
                 HCCT-HHHHHHHHHHHHHSCSSTTEEEEESSS...CEEETTEEE-TT-EEEEEHHHHHT-TTTS.SSTTS--GGGGB- CS
        p450 317 dlqklpyldavikEtLRlhpvvplllpRevtk...dvvirgylipkGtevivnlyalhrdpevf.pnPeeFdpeRFld 390
                 d ++l +lda+ kEt R +++    + + ++     +   +y+ip G+ v++ +y  h+++e+f  + ++++peRFl+
  EFC36867.1 387 DENNLRLLDACFKETTRQYSLKF-MTGKTTKLdfrTLRYFNYDIPSGQFVSIVPYFSHHSKEYFpFETHTYRPERFLE 463
                 6689***************9988.44455555111455556***********************77**********97 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.0013
                 -TTHHHHHHHHHHHHHHHHHHEEEEESTSTSG CS
        p450 412 CiGerlArmelklflatlLqnFevelqpetdp 443
                 C+G ++ ++  ++f++ lL +++ve++ + ++
  EFC36867.1 555 CLGCNFIHLSSRVFVIELLTHYKVEIP-QWQK 585
                 *************************95.4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (616 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       878  (0.0489709); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 3549.89
//
Query:       EFC36868.1  [L=555]
Description: WD40 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-14   53.9   5.5     0.0022   18.8   0.3    6.1  5  WD40         WD domain, G-beta repeat
    6.4e-07   29.0   1.2    1.5e-05   24.5   0.1    2.6  3  RAB3GAP2_N   Rab3 GTPase-activating protein regulatory subuni
    5.1e-05   23.5   0.0     0.0039   17.5   0.0    3.1  2  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
      0.005   16.9   0.1       0.25   11.4   0.0    3.2  3  BBS2_Mid     Ciliary BBSome complex subunit 2, middle region
  ------ inclusion threshold ------
      0.051   13.5   0.1       0.12   12.3   0.1    1.7  1  F-box-like   F-box-like


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0    0.0013       4.8      14      37 ..     160     187 ..     149     188 .. 0.78
   2 !   18.6   0.0     7e-07    0.0025       5      38 .]     221     269 ..     218     269 .. 0.78
   3 !   18.8   0.3   6.1e-07    0.0022       2      38 .]     287     325 ..     286     325 .. 0.85
   4 ?    2.6   0.0     0.081   2.9e+02       2      38 .]     372     419 ..     371     419 .. 0.68
   5 ?    2.1   0.0      0.12   4.2e+02       8      38 .]     431     461 ..     424     461 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0013
                 EEEE....EETTSSEEEEEETTSEEEEE CS
        WD40  14 tsla....fspdgawlasGsdDgtvriW 37 
                 t++a    f+++  ++asG++Dg ++i+
  EFC36868.1 160 TCFAicnvFNRHTELIASGTRDGLIHIY 187
                 33334466999***************97 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 7e-07
                 EEEESSSS.EEEEEEETTSSE..............EEEEETTSEEEEEE CS
        WD40   5 rtltGHss.vtslafspdgaw..............lasGsdDgtvriWd 38 
                 r+ ++H++ +t+++f  ++ +              l++Gs+D+t+++W+
  EFC36868.1 221 RVKSAHNDeITCMKFLNSQYFtkrsmhsdninsliLLTGSKDRTLKMWK 269
                 5557895569999977777777777778888888778***********6 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 6.1e-07
                 EEEEEEESS.SSEEEEE.EETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtsla.fspdgawlasGsdDgtvriWd 38 
                 +++ tl+ H ++++++   s++ + +++ s+D+t++iWd
  EFC36868.1 287 KLVATLDSHqDWIRDITlISQHPTKIVTTSRDKTIKIWD 325
                 67899****777****877777777999999*******9 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.081
                 EEEEEEESSSS.EEEEE.....EETTSSE......EEEEETTSEEEEEE CS
        WD40   2 qclrtltGHss.vtsla.....fspdgaw......lasGsdDgtvriWd 38 
                 ++++  ++Hs+ ++++       +pd++       ++  s+D+++ i++
  EFC36868.1 372 KLIYQMKAHSDlISDILyvsnqINPDSPKqlipliITI-SYDKSISIFN 419
                 66777889977777776666666777777888863333.5599999986 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.12
                 ESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 ++H ++  sla +    + +++s D+  + W+
  EFC36868.1 431 EAHsTPLFSLASNGKDCF-TTCSVDQFAKQWK 461
                 578666888866666666.99*******9995 PP

>> RAB3GAP2_N  Rab3 GTPase-activating protein regulatory subunit N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.019        68      53      93 ..     152     189 ..     123     198 .. 0.77
   2 ?   -2.4   0.0       0.6   2.1e+03     324     346 ..     247     269 ..     203     269 .. 0.72
   3 !   24.5   0.1   4.1e-09   1.5e-05      71     197 ..     346     482 ..     300     514 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.019
  RAB3GAP2_N  53 eeeiItailclplsskssqgspdwtviavGlssGylrfyte 93 
                  +e I +  c+ + +     + +  +ia G+ +G +++yt 
  EFC36868.1 152 MTESIHSNTCFAICN---VFNRHTELIASGTRDGLIHIYTR 189
                 345688889999988...33677889*************97 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.6
  RAB3GAP2_N 324 vtDsLgRVlLlDvqagvvvRlWK 346
                  +D++   +Ll   +   +++WK
  EFC36868.1 247 HSDNINSLILLTGSKDRTLKMWK 269
                 46777777777777777777776 PP

  == domain 3  score: 24.5 bits;  conditional E-value: 4.1e-09
  RAB3GAP2_N  71 qgspdwtviavGlssGylrfytengelLlsql.lheepvlkikcv......ssqekeeseelsilypkaivvidglsllsvLracrnqlaraaa...sg 159
                  ++ d+ +++vGl +G l fy+  g +L+ q+  h + +  i  v       s ++     ++i y k i ++++l+l++v++++  +    ++   +g
  EFC36868.1 346 ADHLDKGYLIVGLANGNLQFYDVMGGKLIYQMkAHSDLISDILYVsnqinpDSPKQLIPLIITISYDKSISIFNALTLERVIQVSEAHSTPLFSlasNG 444
                 45889999**************9887777666278899999*963676665555566666789*********************999966333322244 PP

  RAB3GAP2_N 160 sdsvseseekleykkwklqsqdkinDaaivgllkpstf 197
                 +d  +  +     k+wk++++d   +   +g+ k++++
  EFC36868.1 445 KDCFTTCSVDQFAKQWKIERNDCKLEQLLIGPEKHKQL 482
                 44444444444668888887777777777776555554 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.065   2.3e+02      47      74 ..     169     196 ..     144     238 .. 0.72
   2 !   17.5   0.0   1.1e-06    0.0039      19      88 ..     313     388 ..     301     392 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.065
  ANAPC4_WD40  47 kpdgklLavaysdgevrlldaesgkvvh 74 
                  +   +l+a ++ dg ++++    gk  +
   EFC36868.1 169 NRHTELIASGTRDGLIHIYTRDYGKEFS 196
                  5566788899999999888877776554 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 1.1e-06
  ANAPC4_WD40  19 llvfRlngqrvwtleedkedsevr.....sLaWkpdgkl....Lavaysdgevrlldaesgkvvhslsvksekavtclg 88 
                  +  +R +  ++w+l+    d+e++      LaW   ++l    L v+ ++g+++++d+  gk++ +++++s+  ++ + 
   EFC36868.1 313 VTTSRDKTIKIWDLN--RLDKEITidlpsTLAWTVADHLdkgyLIVGLANGNLQFYDVMGGKLIYQMKAHSDL-ISDIL 388
                  667788889999995..4444544447779***9888866666***************************996.76665 PP

>> BBS2_Mid  Ciliary BBSome complex subunit 2, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.25   8.8e+02       4      29 ..     164     189 ..     127     202 .. 0.62
   2 ?   -0.0   0.0      0.25     9e+02       9      44 ..     250     285 ..     245     292 .. 0.72
   3 !   11.4   0.0   6.9e-05      0.25      12      68 ..     309     369 ..     302     404 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.25
    BBS2_Mid   4 ladvdgdgeneLvv.gsddfeirvfke 29 
                 +++v +  ++eL++ g+ d  i ++ +
  EFC36868.1 164 ICNVFNR-HTELIAsGTRDGLIHIYTR 189
                 3344443.3333332555555555554 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.25
    BBS2_Mid   9 gdgeneLvvgsddfeirvfkeeelvaeitetekvvs 44 
                 + ++  L+ gs+d +++++k     +e+   ++ +s
  EFC36868.1 250 NINSLILLTGSKDRTLKMWKITFSEFETLSGKRSIS 285
                 445566899*******99998777777666665555 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 6.9e-05
    BBS2_Mid  12 eneLvvgsddfeirvfkeeelvaeite....tekvvslarlekerfayaleNGtvgvyekk 68 
                  +++v  s d +i++++ ++l +eit+    t + ++  +l+k  ++++l+NG +  y+ +
  EFC36868.1 309 PTKIVTTSRDKTIKIWDLNRLDKEITIdlpsTLAWTVADHLDKGYLIVGLANGNLQFYDVM 369
                 5789************98888888776111155666777888999*************965 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   3.3e-05      0.12       8      46 ..      10      53 ..       7      55 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.3e-05
  F-box-like  8 iLlqIFsyLpps.....dLlrlalVCrrWrrvaldtplLWrrlv 46
                +L  IFs++p +     +++rl lVC+ ++ + +    +W+r++
  EFC36868.1 10 LLGSIFSFVPINrlallSQSRLDLVCKNFYHFLHFKINFWQRIY 53
                7889***9886644444677888********9966668999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       577  (0.0321825); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 3202.15
//
Query:       EFC36869.1  [L=1233]
Description: DNA-directed RNA polymerase II [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   1.7e-127  425.8   0.1   2.5e-127  425.2   0.1    1.3  1  RNA_pol_Rpb2_6  RNA polymerase Rpb2, domain 6
    1.2e-51  175.1   0.3    1.9e-51  174.5   0.3    1.3  1  RNA_pol_Rpb2_1  RNA polymerase beta subunit
    2.5e-40  138.2   0.0    4.7e-40  137.2   0.0    1.5  1  RNA_pol_Rpb2_2  RNA polymerase Rpb2, domain 2
      3e-32  110.9   0.3    7.3e-32  109.6   0.3    1.7  1  RNA_pol_Rpb2_7  RNA polymerase Rpb2, domain 7
    3.8e-25   87.8   0.1    9.6e-25   86.6   0.1    1.7  1  RNA_pol_Rpb2_3  RNA polymerase Rpb2, domain 3
    5.7e-23   81.0   0.2    1.4e-22   79.7   0.2    1.8  1  RNA_pol_Rpb2_4  RNA polymerase Rpb2, domain 4
    4.7e-17   62.3   0.0    1.2e-16   60.9   0.0    1.8  1  RNA_pol_Rpb2_5  RNA polymerase Rpb2, domain 5
  ------ inclusion threshold ------
      0.023   14.8   2.5       0.18   11.9   0.3    3.1  4  RasGAP_C        RasGAP C-terminus
       0.13   12.2   0.3       0.32   11.0   0.3    1.6  1  OrfB_Zn_ribbon  Putative transposase DNA-binding domain


Domain annotation for each model (and alignments):
>> RNA_pol_Rpb2_6  RNA polymerase Rpb2, domain 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  425.2   0.1  1.3e-130  2.5e-127       3     390 .]     769    1137 ..     767    1137 .. 0.93

  Alignments for each domain:
  == domain 1  score: 425.2 bits;  conditional E-value: 1.3e-130
                      HT-SS-TTB-HHHHHHHHHHGGGB-S---TTTTT---SSEEEESS----SSB-S.TTTTTS........GGGS-SEEEEEBBBS--TTTTTTT CS
  RNA_pol_Rpb2_6    3 klapvvehvqspriiiqaamekqalgiyslnkfkrsnqktyllcinqkPlvktgdkveagqvldgpatekgelalGqnavVAvmsyeGYniED 95  
                      +++p+++h+qspr+++q+am+kqa+g+y +n  +r+++  ++l+++q+Plv+t+  +e+++        +gel++GqnavVA+++y+GYn+ED
      EFC36869.1  769 SIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFQQRMDTLAHVLYYPQRPLVTTQ-PMEYLR--------FGELPAGQNAVVAIACYSGYNQED 852 
                      689***************************************************.******........************************ PP

                      -EEEBCHHHHTTTT-EEEEEE..EEE--SSSS-..--.-S--..-.....-SS-GGGS-TTSB--SS-EEETT-EEE---..B-----...-- CS
  RNA_pol_Rpb2_6   96 aiilnerlvdrdvftsihikeyeveardtklge..eeitrdipnv.....seealkkLdedGivrvgaevkegdilvgkvtkgeteltpeekl 181 
                      ++i+n++++dr++f+s+++++  ++ +++k+g+   e +++++++     + + ++kL++dGi+ +g +v+  di++gk+        pee  
      EFC36869.1  853 SVIMNQSAIDRGLFRSVFYRT--YSDHERKKGNflLENFEKPKRDttagmKTSTYEKLEDDGIIAPGVRVSGSDIIIGKT-----VPLPEESA 938 
                      *********************..555444444435666777766678889999**************************7.....34455444 PP

                      ---------..-B---EE--TT-EEEEEEEEE.......EE-TT--EEEEEEEEEEE---TT-BEEETTS---BBEEEB-TTTSEEETTS--- CS
  RNA_pol_Rpb2_6  182 lraifgekarevkdtslrvksgeegvVdkvkvfsrekgdelkagvnklvkvyvaqkRklqvGDKfasrhGqKGvvslilpqeDmPfledGivv 274 
                          +++++++  d s+ ++s+e+g+Vd+v v       ++++++ k+vk++v+  R +q+GDKf+srhGqKG+++++++qeD+Pf+++Giv+
      EFC36869.1  939 K---QKTSRQTRLDMSTPLRSNENGIVDTVVV-------TTDSEGFKFVKIKVRVVRIPQIGDKFSSRHGQKGTCGITYRQEDLPFTREGIVP 1021
                      3...333334468999****************.......88999************************************************* PP

                      SEEE-GGGCHHH-BTTHHHHHHHHHCCCSSSS--B--TT-...-HHHHHHHHHTTS-TT-EE-EEETTTS-B-SS-EEB-EEEEEEBS--CCC CS
  RNA_pol_Rpb2_6  275 DivlNPlgvPSRmtigqllEtllgkaaalegkkvdatvFdgakeeeikelLeeagleasGkevlydGrtGekleaeifvGviYylkLkhlved 367 
                      Di++NP+++PSRmt+gql+E+llgk+++l+g++ dat+F+ a+ ++++e+L++ g++++++ev+++G tG+klea+if+G++Yy++Lkh+v+d
      EFC36869.1 1022 DIIVNPHAIPSRMTVGQLIECLLGKISSLSGNEGDATPFTDANVNYFSEMLHSLGYQKRANEVMFNGHTGRKLEAQIFIGPTYYQRLKHMVDD 1114
                      ****************************************9999************************************************* PP

                      S----SS--B-TTT--B-SCGGG CS
  RNA_pol_Rpb2_6  368 KihaRstGpyslltqQPlgGkaq 390 
                      Kih+R++Gp ++lt+QP++G+a+
      EFC36869.1 1115 KIHSRARGPLQNLTRQPVEGRAR 1137
                      *********************96 PP

>> RNA_pol_Rpb2_1  RNA polymerase beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  174.5   0.3   9.6e-55   1.9e-51       1     202 [.      67     494 ..      67     495 .. 0.97

  Alignments for each domain:
  == domain 1  score: 174.5 bits;  conditional E-value: 9.6e-55
                     CTTHHHHHHHHHHHHTHHHHHCTTSSECCHCSSSHCSSSC............EEEEEEEEEEESCSSECTT...SCEEES.HHHHHHCTSBXEEE CS
                     xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............xxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxx RF
  RNA_pol_Rpb2_1   1 gLvsqqldSFnkfveqdlekiikeeaaieseeeiqssgee............lelkfvsirlgkPvvdesd...asereiyPkearlrnltYsap 80 
                     gLv+qqldSFn f++q++++ ++  ++i + + ++++ ++            +++kf++i+l++P+vd ++    +  ++yP++arlrnltYs+p
      EFC36869.1  67 GLVRQQLDSFNVFIQQTIQELVEGTSEIMLSSSASYKVGQkrdqqqnqpqfkYNIKFGQIYLSRPTVDTKSeqiEAYSSVYPNDARLRNLTYSSP 161
                     69***************************9999999888789999***********************95523234578**************** PP

                     EEEEEEEEECCCC....................TCCEEEEEEEEEEEEEXBTTSTTSSSTTS.HHHHHHTTS.TTS..SSEEETTCEEEEXEEEE CS
                     xxxxxxxxxxxxx....................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  RNA_pol_Rpb2_1  81 lyvklklvvyekd....................nkeeikeeevyiGelPlMlrskacvlseaseeelvelkEcpldqGGyFiinGtekvivaqek 155
                     lyv+++ + ++                       ++ + ++++ +G +P+Mlrs +c+lse++  ++++++Ecp d GGyFiinG ekvi+aqe+
      EFC36869.1 162 LYVDIHEKKITLRpgstaniytaqvgeedtddfIVQSKIHNQIPLGSIPIMLRSVYCMLSEVQ--DVTDVGECPFDSGGYFIINGGEKVIIAQER 254
                     *****9988766689**************99998999999********************985..79**************************** PP

                     ............................................................................................... CS
                     ............................................................................................... RF
  RNA_pol_Rpb2_1 156 ............................................................................................... 155
                                                                                                                    
      EFC36869.1 255 matnhvyvfkkamskfsyvaeirssqeggyrapsgffikmepkqgnkkggigglihatipyirqdipivilfralscqadkeiikhiiynlndgq 349
                     *********************************************************************************************** PP

                     ............................................................................................... CS
                     ............................................................................................... RF
  RNA_pol_Rpb2_1 156 ............................................................................................... 155
                                                                                                                    
      EFC36869.1 350 mmellrpsleeavavlsntvaldyigkrgntlgasqekrmnhaeeilqkemlphvgigdtsydrkayfigymvhrlllgalgrrplddrdhygnk 444
                     *********************************************************************************************** PP

                     ...XHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTSSSSSHHHHSCSHHHH CS
                     ...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  RNA_pol_Rpb2_1 156 ...laGeLlaslfrvllkklerdvkerlqksleklddlmlqllvnakpit 202
                        laG Ll+ lf +l+kk+++++ ++l+ks+ k  ++ ++ +vn ++it
      EFC36869.1 445 rleLAGGLLQGLFLQLFKKVVKEMESTLKKSILKSSEIDVAPAVNKRTIT 494
                     ***********************************************998 PP

>> RNA_pol_Rpb2_2  RNA polymerase Rpb2, domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.2   0.0   2.4e-43   4.7e-40       2     190 .]     257     447 ..     256     447 .. 0.90

  Alignments for each domain:
  == domain 1  score: 137.2 bits;  conditional E-value: 2.4e-43
                     TSCEEEEE-SSSSSE................SSSCCEECCCEEEEECCCCSTSCEEEEECTTSSSEEEHHHHHHHTT--STTHHHHHHTSSSTTH CS
  RNA_pol_Rpb2_2   2 sngiyvekekdknki................satvtsslisqrgsvlklekdgktliwtriskkrkipivivlkAlglvsdreIlericydseds 80 
                     +n++yv+k++  +                  s+++ +++ +q++   k  ++ + + +t ++++++ipivi+++Al ++ d+eI ++i+y+ +d 
      EFC36869.1 257 TNHVYVFKKAMSKFSyvaeirssqeggyrapSGFFIKMEPKQGN--KKGGIG-GLIHATIPYIRQDIPIVILFRALSCQADKEIIKHIIYNLNDG 348
                     79999998876554457898999999998888888888888888..455554.5666999*********************************** PP

                     HHHHHHHHHHHHHCTSSSCHHHHHHHHH.CSSTTSSSCCCCCHHHHHHHCHHHHHHHTTTTSSTTTTTSSSTCHH..HHHHHHHHHHHHHHHHTT CS
  RNA_pol_Rpb2_2  81 qlleelleeleekeeiqtqeealdyigk.vvalrrgeearlqsareilqkrydlgeigreklnkhlglseslenkrlkaqdilymidrLlslklg 174
                     q++e+l+++lee+  + + ++aldyigk + +l+ ++e+r+ +a+eil         ++e+l+ h+g+      +  ka++i+ym++rLl+ +lg
      EFC36869.1 349 QMMELLRPSLEEAVAVLSNTVALDYIGKrGNTLGASQEKRMNHAEEIL---------QKEMLP-HVGIGDTSYDR--KAYFIGYMVHRLLLGALG 431
                     ***********************************************9.........59****.****9996666..****************** PP

                     SSSS--TTSGGGEEEE CS
  RNA_pol_Rpb2_2 175 rrevDDiDhlgnkRvr 190
                     rr++DD+Dh+gnkR++
      EFC36869.1 432 RRPLDDRDHYGNKRLE 447
                     **************95 PP

>> RNA_pol_Rpb2_7  RNA polymerase Rpb2, domain 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.6   0.3   3.7e-35   7.3e-32       1      86 [.    1139    1230 ..    1139    1231 .. 0.98

  Alignments for each domain:
  == domain 1  score: 109.6 bits;  conditional E-value: 3.7e-35
                      BBEEEEHHHHHHHHHHTBHHHHHHHHTTTTTEEEEEEESSSSSCCCEE......EBTTTTCSSSEEEEEEEHHHHHHHHHHHHTTBEEEEES CS
  RNA_pol_Rpb2_7    1 GGlrfGEMErdaliayGaaalLkerltikSDavevdvcgrckllaaan......eCkivkseekiekveipeafklLlqeLqslgialklll 86  
                      GGlrfGEMErd++i++G+aa Lkerl++ SD+++v++c+ c+++a+an      +C  +++++++++v ip+afkl++qeL+++++a+++++
      EFC36869.1 1139 GGLRFGEMERDCMISHGSAAWLKERLFQVSDEYRVHICNVCGMMATANikqqqfKCDACDNKTSFSQVFIPYAFKLMIQELMAMNLAVRIIT 1230
                      9*********************************************99****************************************9975 PP

>> RNA_pol_Rpb2_3  RNA polymerase Rpb2, domain 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.6   0.1   4.8e-28   9.6e-25       1      68 []     520     584 ..     520     584 .. 0.98

  Alignments for each domain:
  == domain 1  score: 86.6 bits;  conditional E-value: 4.8e-28
  RNA_pol_Rpb2_3   1 qvldrlnplselshlrrvsslrgglskerkttevRdlhpshwGriCpveTPEGencGlvksLallarv 68 
                     qvl+rl+++s+lshlrr++++   ++++ k++++R+lh+++wG iCp+eTPEG  cGlvk+Lal++++
      EFC36869.1 520 QVLNRLTYTSTLSHLRRLNTP---IERSGKQAAPRQLHNTQWGVICPAETPEGGACGLVKNLALMSYI 584
                     89*******************...*****************************************987 PP

>> RNA_pol_Rpb2_4  RNA polymerase Rpb2, domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.7   0.2   7.1e-26   1.4e-22       1      62 []     619     680 ..     619     680 .. 0.99

  Alignments for each domain:
  == domain 1  score: 79.7 bits;  conditional E-value: 7.1e-26
                     EECTT-BEEE-S-HCCHHHHHHHHCCTTSS-TT-EEEE-TTT--EEEE-SSEEB-EEEEE-S CS
  RNA_pol_Rpb2_4   1 VfvNGrllGvtrdpkklvetlRelRRkgkiseevsivlnekqkevkiatDgGRvcRPliiVe 62 
                     Vf+NG ++Gv++ p++lv++lR lRR+g ++ +vsiv++ +++ev+i++D+GR+ RPl+iV+
      EFC36869.1 619 VFLNGMWMGVHHTPDELVKHLRVLRRTGAVDMQVSIVRDVREREVRIWCDSGRCARPLFIVD 680
                     9***********************************************************95 PP

>> RNA_pol_Rpb2_5  RNA polymerase Rpb2, domain 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.9   0.0   6.3e-20   1.2e-16       1      58 []     703     760 ..     703     760 .. 0.95

  Alignments for each domain:
  == domain 1  score: 60.9 bits;  conditional E-value: 6.3e-20
                     HHHHHHTTSEEEEEHHHHTT--EESSTTTCSST-SSTTTSS--TTSSSST-SEEES-G CS
  RNA_pol_Rpb2_5   1 wddLlregvvEylDaeEEetamIamtpedleksreekealeekenskshtyTHcEIhP 58 
                     wd+Ll++g+vE++D+eEEe +mIam+ ++l ++r+  ++ ++++  +++ yTH EIhP
      EFC36869.1 703 WDNLLEQGLVELIDTEEEESIMIAMDFRELVEKRSSANEGKSRKGGSRQPYTHAEIHP 760
                     *********************************8888888888888888********9 PP

>> RasGAP_C  RasGAP C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.3     9e-05      0.18      68     121 ..      68     120 ..      58     123 .. 0.80
   2 ?   -1.6   0.0       1.4   2.7e+03      65     126 ..     692     759 ..     688     764 .. 0.63
   3 ?    0.3   0.0      0.35     7e+02     101     132 ..     884     915 ..     847     916 .. 0.78
   4 ?   -3.8   0.0       6.5   1.3e+04      74     118 ..    1169    1210 ..    1164    1212 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 9e-05
    RasGAP_C  68 ylesqlesYkayienvleqlkkkkgklpfskqyfkkrelkksgklpkfgsykys 121
                  +++ql+s++  i++++++l ++ +++  s+++++k+ +k+  +++++ ++ky+
  EFC36869.1  68 LVRQQLDSFNVFIQQTIQELVEGTSEIMLSSSASYKVGQKRD-QQQNQPQFKYN 120
                 5789*******************8886667778888875555.45666999997 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.4
    RasGAP_C  65 knnylesqlesYkayienvleqlkkkkgk......lpfskqyfkkrelkksgklpkfgsyk.ysakqLe 126
                 + + l++   ++++ +e+ l +l +++ +      + f++   +kr++ ++gk++k gs + y++++ +
  EFC36869.1 692 HVQALRENTMNWDNLLEQGLVELIDTEEEesimiaMDFRE-LVEKRSSANEGKSRKGGSRQpYTHAEIH 759
                 6667777777788888888888866653356777666555.6666666666666666664338887766 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.35
    RasGAP_C 101 fkkrelkksgklpkfgsykysakqLeekgVLl 132
                 f  ++ +k ++ ++ g+   + ++Le++g+++
  EFC36869.1 884 FLLENFEKPKRDTTAGMKTSTYEKLEDDGIIA 915
                 44455688888999999999**********95 PP

  == domain 4  score: -3.8 bits;  conditional E-value: 6.5
    RasGAP_C   74 esYkayienvleqlkkkkgklpfskqyfkkrel.kksgklpkfgsy 118 
                  ++Y+ +i nv   +++++     ++q fk     +k++ ++ f +y
  EFC36869.1 1169 DEYRVHICNVCGMMATAN----IKQQQFKCDACdNKTSFSQVFIPY 1210
                  789999999999998886....444444444443555556666665 PP

>> OrfB_Zn_ribbon  Putative transposase DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.3   0.00016      0.32      21      55 ..    1166    1200 ..    1156    1202 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00016
  OrfB_Zn_ribbon   21 evnpayTSktCseCgsknkealsgrtfkCpnCgfe 55  
                      +v+ +y    C++Cg   + + ++++fkC++C  +
      EFC36869.1 1166 QVSDEYRVHICNVCGMMATANIKQQQFKCDACDNK 1200
                      6777777789**********************865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1233 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       692  (0.0385967); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.96u 0.33s 00:00:01.29 Elapsed: 00:00:00.54
# Mc/sec: 6929.45
//
Query:       EFC36870.1  [L=754]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.5   4.9      0.063   13.3   0.7    2.5  2  UL42      HCMV UL42


Domain annotation for each model (and alignments):
>> UL42  HCMV UL42
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.7   3.5e-06     0.063      31      61 ..      23      53 ..       2      77 .. 0.77
   2 ?   -0.2   0.3     0.051   9.2e+02       9      41 ..     350     382 ..     343     415 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3.5e-06
        UL42 31 stppppppdcspppyrppyclvsspsprhtf 61
                 + pp  p   pp y p  +l+ssps +h  
  EFC36870.1 23 DSIPPESPAHKPPSYSPSVALISSPSNQHHQ 53
                5668899999*****************9965 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.051
        UL42   9 drdhddapptyeqamglcpttvstppppppdcs 41 
                 d  h  + pty+ +      + s p pp  + +
  EFC36870.1 350 DFTHSPTSPTYQSSWSAFKEANSLPSPPSLNNT 382
                 667888899999999999999999998876544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (754 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1433  (0.0799264); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.50
# Mc/sec: 4498.03
//
Query:       EFC36871.1  [L=445]
Description: hypothetical protein NAEGRDRAFT_75438 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0014   18.5   0.7     0.0075   16.1   0.1    2.2  2  F-box       F-box domain
  ------ inclusion threshold ------
      0.076   12.9   0.1       0.16   11.9   0.1    1.5  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.1   8.4e-07    0.0075       9      37 ..     111     140 ..      99     148 .. 0.91
   2 ?    0.0   0.0     0.094   8.4e+02       8      22 ..     311     325 ..     310     335 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 8.4e-07
                 HHHHHHHHTS-HHH.HHHHCTT-HHHHHHH CS
       F-box   9 evlrhILerLplsd.llalrrVSkgwrili 37 
                 +v  +I++ L+  +  l lr V+k+w+++i
  EFC36871.1 111 DVFQEIMSCLDVESiALILRGVCKTWHDWI 140
                 5889************************98 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.094
                 HHHHHHHHHTS-HHH CS
       F-box   8 sevlrhILerLplsd 22 
                 +e+++hI++  +l +
  EFC36871.1 311 DELIKHIMSLIGLDS 325
                 79******9887766 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   1.8e-05      0.16       8      35 ..     112     140 ..     110     152 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.8e-05
  F-box-like   8 iLlqIFsyLppsdLlr.lalVCrrWrrva 35 
                 +  +I s+L+ ++++  l+ VC+ W++ +
  EFC36871.1 112 VFQEIMSCLDVESIALiLRGVCKTWHDWI 140
                 7789*********99978********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       502  (0.0279993); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 3043.24
//
Query:       EFC36872.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-18   65.7  45.4     0.0057   16.6   0.3    9.7 10  LRR_6       Leucine Rich repeat
    6.5e-12   45.5  52.0    0.00022   21.5   1.3    6.7  8  LRR_4       Leucine Rich repeats (2 copies)
      1e-08   34.8  46.2    0.00043   20.0   3.2    6.9  6  LRR_8       Leucine rich repeat
    1.8e-05   24.5   0.4    6.2e-05   22.8   0.4    1.8  1  F-box-like  F-box-like
    0.00015   21.3  13.4       0.22   11.0   0.2    3.6  4  LRR_9       Leucine-rich repeat
  ------ inclusion threshold ------
       0.47   11.2  45.2       0.55   11.0   0.5    9.3  8  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.2     0.003       8.8       7      18 ..      80      91 ..      76      97 .. 0.83
   2 !   16.6   0.3   1.9e-06    0.0057       3      23 ..     103     123 ..     102     123 .. 0.92
   3 !   16.3   0.1   2.3e-06     0.007       4      24 .]     131     151 ..     129     151 .. 0.93
   4 !   11.3   0.3   9.7e-05      0.29       5      24 .]     159     178 ..     156     178 .. 0.93
   5 !   13.1   0.3   2.5e-05     0.076       3      24 .]     184     205 ..     182     205 .. 0.92
   6 !    7.9   0.1    0.0012       3.5       5      21 ..     213     229 ..     211     232 .. 0.89
   7 !    9.7   0.7   0.00031      0.93       3      18 ..     237     252 ..     236     253 .. 0.91
   8 ?    0.5   0.1      0.28   8.2e+02       3      13 ..     262     272 ..     260     275 .. 0.84
   9 !   10.6   1.8   0.00016      0.48       2      16 ..     288     302 ..     287     303 .. 0.88
  10 ?   -1.6   0.0       1.3   3.8e+03       2      14 ..     314     325 ..     313     328 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.003
       LRR_6  7 eLdLsgNdIgDe 18
                +LdLs N +gD+
  EFC36872.1 80 SLDLSNNLLGDA 91
                8*********96 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 1.9e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt+L+Ls N++++ G++ L
  EFC36872.1 103 CNLTKLNLSRNELSNNGVSYL 123
                 79****************865 PP

  == domain 3  score: 16.3 bits;  conditional E-value: 2.3e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L+eL+L gN I+ eG+++++
  EFC36872.1 131 NLQELNLEGNRISSEGLQSIS 151
                 79****************996 PP

  == domain 4  score: 11.3 bits;  conditional E-value: 9.7e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L++L+L+ N I+ +G++aL+
  EFC36872.1 159 LKTLNLNQNLIDESGVIALS 178
                 9*****************96 PP

  == domain 5  score: 13.1 bits;  conditional E-value: 2.5e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt L+L+ N+I + G+++++
  EFC36872.1 184 SCLTNLSLNVNNIRNLGVKSIS 205
                 79*****************996 PP

  == domain 6  score: 7.9 bits;  conditional E-value: 0.0012
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 L+ L+Lsg+++++e ++
  EFC36872.1 213 LQILSLSGCGLDNEDVK 229
                 899***********886 PP

  == domain 7  score: 9.7 bits;  conditional E-value: 0.00031
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 t+L  LdLs+N I+D+
  EFC36872.1 237 TNLVDLDLSDNLISDV 252
                 7999**********96 PP

  == domain 8  score: 0.5 bits;  conditional E-value: 0.28
       LRR_6   3 thLteLdLsgN 13 
                 + L +L+L+gN
  EFC36872.1 262 MRLSKLNLKGN 272
                 57889*****9 PP

  == domain 9  score: 10.6 bits;  conditional E-value: 0.00016
       LRR_6   2 nthLteLdLsgNdIg 16 
                  ++Lt L+Ls+N+I 
  EFC36872.1 288 LSNLTQLNLSCNCIA 302
                 589**********95 PP

  == domain 10  score: -1.6 bits;  conditional E-value: 1.3
       LRR_6   2 nthLteLdLsgNd 14 
                 n +L+  dL++Nd
  EFC36872.1 314 NKKLQ-IDLQDND 325
                 55666.8999998 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   5.5     0.004        12       5      33 ..      80     113 ..      76     116 .. 0.74
   2 !   17.2   6.7   1.7e-06    0.0052       1      37 [.     103     143 ..     103     152 .. 0.75
   3 !   18.4   3.7   6.9e-07    0.0021       2      37 ..     131     170 ..     130     178 .. 0.79
   4 !   11.0   6.9   0.00016      0.46       2      39 ..     158     199 ..     157     203 .. 0.80
   5 !    8.1   4.5    0.0012       3.6       3      35 ..     186     222 ..     184     230 .. 0.73
   6 !   21.5   1.3   7.3e-08   0.00022       3      43 ..     213     256 ..     211     257 .. 0.89
   7 !   20.3   2.7   1.8e-07   0.00055       1      36 [.     237     274 ..     237     281 .. 0.87
   8 !   10.0   7.4   0.00031      0.92       3      44 .]     264     309 ..     263     331 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.004
                 EEE--SS---E-S-...HH..H-TT--EEE-.-S CS
       LRR_4   5 vLdLsnNqltdipl...le..klpnLkeLdLsgN 33 
                 +LdLsnN l d      +e     nL++L+Ls+N
  EFC36872.1  80 SLDLSNNLLGDACIymlCEspFACNLTKLNLSRN 113
                 69******99955566522432688******999 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 1.7e-06
                 SS--EEE--SS---E-S-..HH..H.-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..k.lpnLkeLdLsgNnlit 37 
                 +nL++L+Ls N l+  +   l     l nL+eL+L gN +i+
  EFC36872.1 103 CNLTKLNLSRNELSNNGVsyLTstPfLANLQELNLEGN-RIS 143
                 69*******99977666644225533*********999.663 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 6.9e-07
                 S--EEE--SS---E-S-..HH..H.-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..le..k.lpnLkeLdLsgNnlit 37 
                 nL++L+L +N++++ +l  ++  + +  Lk+L+L++N li+
  EFC36872.1 131 NLQELNLEGNRISSEGLqsISecSfMSGLKTLNLNQN-LID 170
                 9**********88766654225766999******777.764 PP

  == domain 4  score: 11.0 bits;  conditional E-value: 0.00016
                 S--EEE--SS---E-S-..HH...H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLsgNnlitdl 39 
                  L++L+L++N + + +   l+    +  L+ L+L + n+i++l
  EFC36872.1 158 GLKTLNLNQNLIDESGViaLShspYMSCLTNLSL-NVNNIRNL 199
                 69*******9*99877766336656*********.65688877 PP

  == domain 5  score: 8.1 bits;  conditional E-value: 0.0012
                 --EEE--SS-.....--E-S-HHH-TT--EEE-.-S-- CS
       LRR_4   3 LevLdLsnNq.....ltdiplleklpnLkeLdLsgNnl 35 
                 L++L+L+ N+     +++i++   l +L+ L+Lsg+  
  EFC36872.1 186 LTNLSLNVNNirnlgVKSISSSIFLADLQILSLSGC-G 222
                 9******55623555666666446999*******99.4 PP

  == domain 6  score: 21.5 bits;  conditional E-value: 7.3e-08
                 --EEE--SS---E-S-...HHH.-TT--EEE-.-S-----GGGGX CS
       LRR_4   3 LevLdLsnNqltdipl...lek.lpnLkeLdLsgNnlitdldeLk 43 
                 L++L+Ls++ l   +     ++ ++nL  LdLs+N li+d+++L+
  EFC36872.1 213 LQILSLSGCGLDNEDVkwiANGmMTNLVDLDLSDN-LISDVSSLA 256
                 99**********99998765577*********888.*****9997 PP

  == domain 7  score: 20.3 bits;  conditional E-value: 1.8e-07
                 SS--EEE--SS---E-S-HH...H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpnLkeLdLsgNnli 36 
                 +nL  LdLs+N ++d+++l+   kl  L +L+L gN +i
  EFC36872.1 237 TNLVDLDLSDNLISDVSSLAsysKLMRLSKLNLKGN-YI 274
                 7999**************888867*********999.55 PP

  == domain 8  score: 10.0 bits;  conditional E-value: 0.00031
                 --EEE--SS---E-S-HH.....H-TT--EEE-.-S-----GGGGXX CS
       LRR_4   3 LevLdLsnNqltdiplle.....klpnLkeLdLsgNnlitdldeLkn 44 
                 L +L+L +N + + + l      +l nL++L+L ++n i +++e++n
  EFC36872.1 264 LSKLNLKGNYIIEKDALViltsnSLSNLTQLNL-SCNCIANIEEIRN 309
                 778999999888777755555746*********.7779999998765 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9  11.5    0.0037        11       5      61 .]      80     142 ..      77     142 .. 0.68
   2 !    9.8  11.9   0.00022      0.66       2      61 .]     104     169 ..     103     169 .. 0.83
   3 !   10.0   4.2   0.00018      0.55       8      61 .]     142     196 ..     141     196 .. 0.78
   4 ?    4.3   2.2     0.011        34       3      33 ..     186     219 ..     184     220 .. 0.82
   5 !   20.0   3.2   1.4e-07   0.00043       3      61 .]     213     274 ..     211     274 .. 0.92
   6 !   10.8   2.1    0.0001      0.31      22      41 ..     286     305 ..     283     325 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0037
                 EEE-TTS--SE.....E-TTSSTT-TT--EEE--SS---G...GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   5 sLdLsnNrlts.....lddeaFkglsnLkvLdLsnNlltt...lspgafsgLpsLrsLdLsgNrL 61 
                 sLdLsnN l +     l+ + F    nL+ L+Ls+N+l+        +   L++L++L+L+gNr+
  EFC36872.1  80 SLDLSNNLLGDaciymLCESPFA--CNLTKLNLSRNELSNngvSYLTSTPFLANLQELNLEGNRI 142
                 66666666654222225566666..5999999999999874534456666799999999999987 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00022
                 T-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS---GGGGGG...GTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllttlspga...fsgLpsLrsLdLsgNrL 61 
                 nLt+L+Ls+N l++ + +  ++   l nL++L+L  N++++   ++   +s ++ L+ L+L++N +
  EFC36872.1 104 NLTKLNLSRNELSNNGVSYLTStpfLANLQELNLEGNRISSEGLQSiseCSFMSGLKTLNLNQNLI 169
                 8*************9999998877799***********98755555111567899*******9986 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00018
                 -TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT...--S-.EEE--SS-- CS
       LRR_8   8 LsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsg...LpsLrsLdLsgNrL 61 
                 +s+  l+s++  +F   s+Lk+L+L++Nl++     a+s+   ++ L+ L L+ N++
  EFC36872.1 142 ISSEGLQSISECSFM--SGLKTLNLNQNLIDESGVIALSHspyMSCLTNLSLNVNNI 196
                 566678899999998..9************998888888744455777777777765 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.011
                 -SEEE-TTS--SEE-TTSSTT...-TT--EEE-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg...lsnLkvLdLs 33 
                 Lt+L+L+ N++ +l+ ++ ++   l  L++L+Ls
  EFC36872.1 186 LTNLSLNVNNIRNLGVKSISSsifLADLQILSLS 219
                 8999999999999999988876678888888887 PP

  == domain 5  score: 20.0 bits;  conditional E-value: 1.4e-07
                 -SEEE-TTS--SEE-TTSSTT..-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg..lsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 L++L+Ls   l + d ++  +  ++nL  LdLs+Nl++   s  + s L +L +L+L gN +
  EFC36872.1 213 LQILSLSGCGLDNEDVKWIANgmMTNLVDLDLSDNLISDvSSLASYSKLMRLSKLNLKGNYI 274
                 899**********9999999999****************556788999************76 PP

  == domain 6  score: 10.8 bits;  conditional E-value: 0.0001
                 TT-TT--EEE--SS---GGG CS
       LRR_8  22 kglsnLkvLdLsnNllttls 41 
                 ++lsnL+ L+Ls+N++  ++
  EFC36872.1 286 NSLSNLTQLNLSCNCIANIE 305
                 67**************9886 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.4   2.1e-08   6.2e-05       8      35 ..      11      39 ..       9      44 .. 0.90

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 2.1e-08
  F-box-like  8 iLlqIFsyLppsdLlrl.alVCrrWrrva 35
                iLl++F +Lp++  +r+ + VC++W+ + 
  EFC36872.1 11 ILLRVFGFLPFQHVVRVySVVCKQWHCIS 39
                9***************66*******9875 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.95   2.8e+03      54      74 ..      66      86 ..      62      91 .. 0.80
   2 !    7.7   0.0   0.00074       2.2      48      77 ..     114     143 ..     105     152 .. 0.89
   3 !   11.0   0.2   7.4e-05      0.22      54     126 ..     147     224 ..     143     233 .. 0.81
   4 !    7.7   4.2   0.00077       2.3      47     113 ..     242     314 ..     230     328 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.95
       LRR_9 54 irkldgfPllkrlktlllnnn 74
                ++ l + P+l  + +l l+nn
  EFC36872.1 66 MQALSNTPMLACVSSLDLSNN 86
                567888999999999999888 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00074
       LRR_9  48 dlsdndirkldgfPllkrlktlllnnnriv 77 
                 +ls+n +  l + P+l  l+ l l+ nri 
  EFC36872.1 114 ELSNNGVSYLTSTPFLANLQELNLEGNRIS 143
                 799**************************7 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 7.4e-05
       LRR_9  54 irkldgfPllkrlktlllnnnrivr...iaegleevlPnleelvltnnelqela..dldPlaslkklellsllknpvt 126
                 ++ + +  ++  lktl ln+n i     ia   + ++ +l++l l+ n++++l+   +   + l +l++lsl  + + 
  EFC36872.1 147 LQSISECSFMSGLKTLNLNQNLIDEsgvIALSHSPYMSCLTNLSLNVNNIRNLGvkSISSSIFLADLQILSLSGCGLD 224
                 5667778899*************87333566777889999************97336888899999999999887665 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.00077
       LRR_9  47 idlsdn...dirkldgfPllkrlktlllnnnrivriaegl...eevlPnleelvltnnelqeladldPlaslk 113
                 +dlsdn   d+  l ++  l rl  l l+ n i+     +   +++l nl++l l+ n++ ++ ++  + + +
  EFC36872.1 242 LDLSDNlisDVSSLASYSKLMRLSKLNLKGNYIIEKDALViltSNSLSNLTQLNLSCNCIANIEEIRNISNSN 314
                 79999944455667788999************99876654334789****************99998876544 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.2     0.093   2.8e+02       4      13 ..      80      89 ..      79     100 .. 0.82
   2 ?    6.9   0.5    0.0042        12       1      13 [.     104     116 ..     104     126 .. 0.82
   3 ?   11.0   0.5   0.00018      0.55       1      22 [.     131     152 ..     131     154 .. 0.83
   4 ?    1.3   3.9      0.28   8.4e+02       2      13 ..     159     172 ..     158     207 .. 0.74
   5 ?    3.7   0.1     0.045   1.4e+02       2      14 ..     213     225 ..     212     233 .. 0.81
   6 ?    2.4   0.1      0.12   3.7e+02       1      15 [.     238     252 ..     238     258 .. 0.79
   7 ?    3.4   0.3     0.059   1.8e+02       2      23 .]     264     291 ..     263     291 .. 0.76
   8 ?    4.2   2.7     0.032        96       1      19 [.     290     313 ..     290     331 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.093
       LRR_1  4 hLdLsnnpll 13
                +LdLsnn l+
  EFC36872.1 80 SLDLSNNLLG 89
                79*****984 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0042
       LRR_1   1 nLrhLdLsnnpll 13 
                 nL++L+Ls+n l+
  EFC36872.1 104 NLTKLNLSRNELS 116
                 8*********985 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00018
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++L+L++n++++ + +s++ 
  EFC36872.1 131 NLQELNLEGNRISSEGLQSISE 152
                 8**********98777777765 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.28
       LRR_1   2 LrhLdLsnnpl..l 13 
                 L++L+L++n +  +
  EFC36872.1 159 LKTLNLNQNLIdeS 172
                 999***99987541 PP

  == domain 5  score: 3.7 bits;  conditional E-value: 0.045
       LRR_1   2 LrhLdLsnnpllg 14 
                 L+ L Ls++ l++
  EFC36872.1 213 LQILSLSGCGLDN 225
                 99*******9854 PP

  == domain 6  score: 2.4 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL  LdLs+n +++ 
  EFC36872.1 238 NLVDLDLSDNLISDV 252
                 7888******98655 PP

  == domain 7  score: 3.4 bits;  conditional E-value: 0.059
       LRR_1   2 LrhLdLsnnpl......lglppnsfqnL 23 
                 L +L+L +n +        l++ns++nL
  EFC36872.1 264 LSKLNLKGNYIiekdalVILTSNSLSNL 291
                 889******9877777744778888776 PP

  == domain 8  score: 4.2 bits;  conditional E-value: 0.032
       LRR_1   1 nLrhLdLsnnpl.....lglppns 19 
                 nL+ L+Ls n++     ++ ++ns
  EFC36872.1 290 NLTQLNLSCNCIanieeIRNISNS 313
                 89*********9777775555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       538  (0.0300073); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 2212.35
//
Query:       EFC36873.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-32  111.7   0.0    2.9e-32  111.4   0.0    1.1  1  TRAPP          Transport protein particle (TRAPP) component
  ------ inclusion threshold ------
       0.13   12.5   0.0       0.22   11.7   0.0    1.3  1  Alpha_Helical  Alpha helical domain


Domain annotation for each model (and alignments):
>> TRAPP  Transport protein particle (TRAPP) component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.4   0.0   3.3e-36   2.9e-32       2     144 ..      24     172 ..      23     174 .. 0.84

  Alignments for each domain:
  == domain 1  score: 111.4 bits;  conditional E-value: 3.3e-36
       TRAPP   2 afllgelvsylqrdskdveevekrLekmGyrvGlrllelllar.......erpretdilevlkfickdlWkllfgkqidnlktnhrge...yvltdnef 90 
                 a+++g+lv+++++d +dv++v+++LekmGy++G+rl+++++++       +    ++++++++ i+k+++k+++g +++ +++++++    +v+++n  
  EFC36873.1  24 AMTYGSLVTQMLKDFEDVAAVNTQLEKMGYKMGMRLIDEFMSKsglgsgaC----REFKDTAESIAKVAFKMFLGVNANITNWSKDQSeysLVFDEN-- 116
                 79*****************************************77755544....9****************************6555555666777.. PP

       TRAPP  91 pltrfvelpke.ls....ylaflcGiirGaLenlgfpakVtahelpsdelrgrttfeik 144
                 pl++fvelp++  +    y++++cG+irGaLe++ ++++++ ++ p   l g+   ei+
  EFC36873.1 117 PLNDFVELPENiKQkrlyYSNIICGVIRGALEMVLMRVDCEFRKCP---LLGDDQSEIR 172
                 *********998334677*******************555544444...4566665665 PP

>> Alpha_Helical  Alpha helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   2.4e-05      0.22      40     113 ..      13      90 ..       6     100 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.4e-05
  Alpha_Helical  40 elakemeselqslkysylepedLakseevkklkekaeeiiealgge...ews.ekfleeaekeekekteesiakvkff 113
                    +   +++sel +++y  l +++L + e+v++++ + e++   +g +   e++ ++ l +   +e + t esiakv f 
     EFC36873.1  13 NKIDKINSELLAMTYGSLVTQMLKDFEDVAAVNTQLEKMGYKMGMRlidEFMsKSGLGSGACREFKDTAESIAKVAFK 90 
                    667899***************************999999777765411144313345555667777889999999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       544  (0.0303419); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.31s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1179.33
//
Query:       EFC36874.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.065   13.9   0.3      0.065   13.9   0.3    3.0  4  LtuB            Late transcription unit B
       0.14   11.7   3.0       0.52    9.9   3.0    1.9  1  Fzo_mitofusin   fzo-like conserved region
       0.67   10.2   2.4        2.2    8.6   2.4    1.9  1  Chi-conotoxin   chi-Conotoxin or t superfamily


Domain annotation for each model (and alignments):
>> LtuB  Late transcription unit B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.3   1.1e-05     0.065      11      50 ..      60      99 ..      54     104 .. 0.89
   2 ?   -2.5   0.0       1.3     8e+03       9      28 ..     235     254 ..     229     269 .. 0.69
   3 ?   -1.6   0.2      0.74   4.4e+03      23      35 ..     313     325 ..     300     346 .. 0.67
   4 ?   -1.7   0.0      0.78   4.6e+03       5      34 ..     332     363 ..     327     371 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.1e-05
        LtuB 11 kkkkfkhhysliskekeslrkrakefdvlvrslldkqvsq 50
                k + ++ h s+ s   e lr++ + ++ lv+s+ d+ v  
  EFC36874.1 60 KASSHEGHISIGSSSSETLRRKGDHHNSLVKSIKDRLVGL 99
                6788999*****************************8865 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.3
        LtuB   9 gekkkkfkhhysliskekes 28 
                  +kk+ f    + is +ke+
  EFC36874.1 235 NQKKRLFTDASTQISCDKEN 254
                 45677777777889988885 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.74
        LtuB  23 skekeslrkrake 35 
                   +ke+ r+r k 
  EFC36874.1 313 KNKKEQCRQRIKA 325
                 3456788887764 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.78
        LtuB   5 kklkgekkkkfkhh...ysliskekeslrkrak 34 
                 kk++ e+++k        s+   + e+l +ra+
  EFC36874.1 332 KKVE-ETQSKMDSSilpMSTTIVKTEQLEQRAD 363
                 5666.6666665441224555567899999986 PP

>> Fzo_mitofusin  fzo-like conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   3.0   8.6e-05      0.52      86     139 ..     310     363 ..     304     366 .. 0.91

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 8.6e-05
  Fzo_mitofusin  86 ltsancshqvqqelsstfarlcqqvdetekeleeeikelekeiekleevqkkak 139
                      ++n ++q +q+++   +++ ++v+et+++++++i  ++++i k e+++++a 
     EFC36874.1 310 SNTKNKKEQCRQRIKAIKKKIMKKVEETQSKMDSSILPMSTTIVKTEQLEQRAD 363
                    56789999*************************************999998875 PP

>> Chi-conotoxin  chi-Conotoxin or t superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   2.4   0.00037       2.2      14      46 ..     285     319 ..     284     329 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00037
  Chi-conotoxin  14 iaSaPsvdaqpkt..kddvplaSfhdnakrtlqrl 46 
                    +aSaPs  ++ k+  kd v+ +Sf  n+k+   + 
     EFC36874.1 285 TASAPSASSNTKNspKDSVASTSFSSNTKNKKEQC 319
                    69****999988666************99876554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2060  (0.114898); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.35s 00:00:01.12 Elapsed: 00:00:00.57
# Mc/sec: 3030.09
//
Query:       EFC36875.1  [L=2131]
Description: FH2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.1e-71  239.8  15.0    5.1e-71  239.8  15.0    3.5  5  FH2            Formin Homology 2 Domain
      4e-24   84.5   2.1    7.7e-24   83.6   0.0    2.7  2  BLUF           Sensors of blue-light using FAD
     0.0054   16.8   1.7       0.02   14.9   0.4    2.8  2  Exonuc_VII_S   Exonuclease VII small subunit
  ------ inclusion threshold ------
       0.15   12.1   4.7      0.098   12.7   0.6    2.9  2  TolA_bind_tri  TolA binding protein trimerisation
       0.71   10.3   3.8       0.62   10.5   0.7    2.4  2  SRP9-21        Signal recognition particle 9 kDa protein (SRP
       0.84    9.9  13.7      0.017   15.4   2.9    3.9  5  RGS            Regulator of G protein signaling domain
        2.4    8.0  12.6       0.41   10.5   0.8    4.1  3  DivIC          Septum formation initiator


Domain annotation for each model (and alignments):
>> FH2  Formin Homology 2 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   1.5      0.47   1.2e+03      30     101 ..      63     125 ..      50     223 .. 0.60
   2 ?   -1.3   0.2      0.35   8.9e+02     277     304 ..     422     449 ..     380     463 .. 0.72
   3 !  239.8  15.0     2e-74   5.1e-71       6     370 ..     692    1054 ..     688    1056 .. 0.95
   4 ?   -4.4   0.9         3   7.8e+03      43      69 ..    1544    1574 ..    1529    1591 .. 0.53
   5 ?   -3.6   0.3       1.8   4.5e+03      41      73 ..    1916    1943 ..    1887    1972 .. 0.47

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.47
                 CCTCCHHHHC......TSHHHHHHHHTBSC--HCCH......HCSCCTTCCESSS-HHHHHHHHHHHHHHTS-HHHHH CS
         FH2  30 dklkeesfek......eldlseleelFsakekkkkkkksekskkskkkkkkvklLdpkrsqniaIlLkklkltaeeiv 101
                 ++  ee+f++      +++++ +e+l +   kkk++    k k+s+ ++++            +IlL+  + t++ i+
  EFC36875.1  63 NEKLEEDFKQyldktfKNQTETIEKLMALPPKKKMEIL--KLKQSQISSQN------------NILLHL-ETTMNNIK 125
                 44444444444444444444444444444444433322..33333334444............444432.23444443 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.35
                 -HHHHHHHHHHHHHHHHHHHHHHHHCCT CS
         FH2 277 nleslekevkklekglkklekelessek 304
                 ++++++k+  +l+++++kl+  +e+ ek
  EFC36875.1 422 QVDTITKDNAQLKDQMEKLKVRIEALEK 449
                 7788888888889999888888888777 PP

  == domain 3  score: 239.8 bits;  conditional E-value: 2e-74
                  --SS-B------EESSGGCTTSCCCCTCCHHHHC..TSHHHHHHHHTBSC--HCCH......HCSCCTTCCESSS-HHHHHHHHHHHHHHTS-HHHH CS
         FH2    6 kpkkkLkplhWdkvkpsqdrstvWdklkeesfek..eldlseleelFsakekkkkkkksekskkskkkkkkvklLdpkrsqniaIlLkklkltaeei 100 
                  k + ++k ++ +k+++++ +++vW k +     +  ++  +ele++F++ +k ++    + +k++k k++ ++lL+  r qn++I++k lk++ +++
  EFC36875.1  692 KASVPTKDVRLNKLDNNKLQKSVWMKKNIHAKLFdiDIPEKELEDMFAQISKSPSVGL-TPEKSEKPKDTTISLLEGPRLQNVSIFMKYLKMPSTQL 787 
                  567789999999************998877766623555689*******999877765.999*********************************** PP

                  HHHHHTTTTCCCTHHHHHHHHHHCGGHHHHHHHHCTCTSGTTB-HHHHHHHHHTTSTTHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHHHH-H CS
         FH2  101 veaileldeealdlellenLlkmaPtkeelkklkeykgevseLseaeqFllelvkiprlekRleallfkstfeeeveelkrslealeaaseeLknsk 197 
                  ve+i+ + +  +++e + +Ll+ +P+++e+++  +++g+ ++L ea++F+ +++k+prl +Rl++++fk ++ e+ + ++++le++ +++ +L +s+
  EFC36875.1  788 VEKIMTISD-DFNEESIGKLLNQVPNEDEIQRQNDFDGDEATLNEADKFIRAMMKVPRLASRLKCWNFKLKYVETKACINPDLETIISTCASLVESE 883 
                  *****9988.99************************************************************************************* PP

                  HHHHHHHHHHHHHHHHSTCSTTCS-SEE-GGGGGGCCCSB-STTTSBHHHHHHHHHHTTSGGGGGHHHHTTTHHHCCTS-HHHHHHHHHHHHHHHHH CS
         FH2  198 kfkklLeliLalGNymNdgtrrgqAkGFkLssLlkLsdvKstdnkttLLHylvkiireklpevldfsseLknvkkaakvnleslekevkklekglkk 294 
                  k+++l+ +iLa+ Ny+     r   +GFkL+sL+kL+++K++ +++tLL+++vk i+++ p++l+++++L+ +++aa+v++++l+++++ +ek+++ 
  EFC36875.1  884 KLQELFAVILAFSNYLS----RTGIHGFKLNSLQKLKETKGNAKNITLLDMIVKHITSAKPDILKVKEDLNMLERAARVEMQTLADKIDSMEKSIAL 976 
                  ****************4....4899************************************************************************ PP

                  HHHHHHHCCTTSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT--TT..CCHHHHHHHHHHHHHHH CS
         FH2  295 lekelessekkeepsdkflevlkeflkeaeeklkkleeelkeakelvkelveYfgedkk..evspeeffkilreFlke 370 
                  l++e++  +k+ +p+d+flev  +fl+e+e+++k ++e+++++ ++   ++e++ged++  + +p+e+f  l++F+++
  EFC36875.1  977 LKTEIQYYSKNPQPNDRFLEVFGSFLNECEDEMKLIKEKQQNMDNQISGVAEFLGEDPNtvKKEPKEMFLMLNSFITD 1054
                  ***********************************************************99999***********987 PP

  == domain 4  score: -4.4 bits;  conditional E-value: 3
                  HHHHHHHTBSC--HCCH..........HCSC CS
         FH2   43 lseleelFsakekkkkkkks....ekskksk 69  
                   se+e  + + +k++ +kk     e+s+ s+
  EFC36875.1 1544 RSEVELQYFSNSKQTLNKKEtesdEQSETST 1574
                  4555555555555555555444332222222 PP

  == domain 5  score: -3.6 bits;  conditional E-value: 1.8
                  SHHHHHHHHTBSC--HCCH......HCSCCTTC CS
         FH2   41 ldlseleelFsakekkkkkkksekskkskkkkk 73  
                  + l+e+++l+++  + + +     ++k+ +k +
  EFC36875.1 1916 ETLDEFLDLYEINIDDQYR-----KVKKLNKME 1943
                  2233333333333332222.....123333333 PP

>> BLUF  Sensors of blue-light using FAD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.5         2     5e+03       3      34 ..    1548    1579 ..    1547    1583 .. 0.80
   2 !   83.6   0.0     3e-27   7.7e-24       2      92 .]    1971    2065 ..    1970    2065 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2
                  EEEEEEEE.TTS-HHHHHHHHHHHHHHHHHHT CS
        BLUF    3 rliYvSkaaeelseeeleeileesrenNkelg 34  
                  +l Y+S++++ l+++e e+  ++ ++ Nk+++
  EFC36875.1 1548 ELQYFSNSKQTLNKKETESDEQSETSTNKQKS 1579
                  689***99999999999888887788887765 PP

  == domain 2  score: 83.6 bits;  conditional E-value: 3e-27
                  EEEEEEEEE.TTS-HHHHHHHHHHHHHHHHHHTEEEEEEEE.TTEEEEEEEEEHHHHHHHHHHHHT-TTEEEEEEEEEEE..ES.S-SSTTCSSE CS
        BLUF    2 vrliYvSkaaeelseeeleeileesrenNkelgitGvLlyd.egvflQvLEGeeeaveelyerIkkDpRhkdvevleeee..ie.ersFskwsmg 92  
                  +rl+Y+Sk +++++++el++i+++++++N++ ++tG+Lly  eg+f+QvLEGe+e v++l+e+IkkD+Rh dv++++ e+  ++ +r+F+ w+m+
  EFC36875.1 1971 IRLTYISKCKKNFNSTELDKIATTATRFNSSINVTGLLLYCkEGIFYQVLEGEKELVSNLFEKIKKDSRHFDVKCVKMETdlCDrDRQFKGWAMN 2065
                  79*****99*****************************99758*********************************999865334899******6 PP

>> Exonuc_VII_S  Exonuclease VII small subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.4   7.9e-06      0.02       2      30 ..     359     387 ..     359     390 .. 0.90
   2 ?   -3.3   0.0       3.8   9.9e+03      30      46 ..    1884    1900 ..    1882    1902 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 7.9e-06
  Exonuc_VII_S   2 EealaeLeeIvekLEsgelsLeeslklye 30 
                   E+ ++ L eIve+LE+ +++L e +k + 
    EFC36875.1 359 EDIFDDLREIVEELENSNVPLAEGIKAVS 387
                   667889*******************9876 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.8
  Exonuc_VII_S   30 eeGvkLlkeCekkLdea 46  
                     +G kL   ++k L+e 
    EFC36875.1 1884 RRGKKLFHSLNKILKEM 1900
                    68999999999999886 PP

>> TolA_bind_tri  TolA binding protein trimerisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.6   3.8e-05     0.098      19      53 ..     415     449 ..     400     450 .. 0.90
   2 ?   -3.5   0.2       4.3   1.1e+04       6      41 ..     949     981 ..     945     983 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.8e-05
  TolA_bind_tri  19 lllelqqqlealqqelreLRGqiEelqyqleqlee 53 
                     +l lq+q+++  ++ ++L+ q+E+l+ ++e le+
     EFC36875.1 415 RNLSLQKQVDTITKDNAQLKDQMEKLKVRIEALEK 449
                    5799***********************99999876 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 4.3
  TolA_bind_tri   6 varLErilearsqlllelqqqlealqqelreLRGqi 41 
                    +  LEr++      +  l  +++++++ ++ L+ +i
     EFC36875.1 949 LNMLERAARV---EMQTLADKIDSMEKSIALLKTEI 981
                    5556666654...34445666666666666666555 PP

>> SRP9-21  Signal recognition particle 9 kDa protein (SRP9)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       1.3   3.4e+03      34      56 ..    1063    1085 ..    1051    1100 .. 0.48
   2 ?   10.5   0.7   0.00024      0.62       8      55 ..    1531    1582 ..    1526    1601 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.3
     SRP9-21   34 kkkkkkkkkkaksekkaskaspp 56  
                  kk+++k+kk++++ +k+++++p+
  EFC36875.1 1063 KKEEEKRKKEESKLAKEKDNRPS 1085
                  33333333333333333333333 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00024
     SRP9-21    8 leqsslLlearPsttrittkYsikakkkkkkkkkkkaksekkaskas....p 55  
                  le+ ++Ll ++P+ + + ++Y  ++k++ +kk+++++++++++++++    +
  EFC36875.1 1531 LERVKRLLGNNPQRSEVELQYFSNSKQTLNKKETESDEQSETSTNKQksfsS 1582
                  678899***************9998888777777777766666665545553 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.7   9.4e+03      11      95 ..      66      83 ..      55      93 .. 0.57
   2 ?   -3.4   0.0       4.4   1.1e+04       2      19 ..     197     214 ..     197     219 .. 0.85
   3 ?   -2.5   0.1       2.3   5.8e+03      67     104 ..     996    1033 ..     966    1068 .. 0.67
   4 ?   15.4   2.9   6.5e-06     0.017      47     118 .]    1501    1626 ..    1492    1626 .. 0.92
   5 ?   -3.6   0.0       5.3   1.3e+04      63      91 ..    1924    1949 ..    1901    1957 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.7
                HHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHH CS
         RGS 11 grslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqe 95
                + + F+++l+++f++                                                                     e
  EFC36875.1 66 LEEDFKQYLDKTFKN-------------------------------------------------------------------QTE 83
                334455555555544...................................................................444 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 4.4
                 HHHHHTSHHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFl 19 
                 l+++++++ g++ F e+ 
  EFC36875.1 197 LTQICKNNEGLEKFLEYP 214
                 579***********9995 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.3
                  TS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHHHHHH CS
         RGS   67 nidkklreelekrlekeqpsrklfeeaqeevfellekd 104 
                  ++  +  +e+e+ ++  +++++ +++  + v e+l +d
  EFC36875.1  996 EVFGSFLNECEDEMKLIKEKQQNMDNQISGVAEFLGED 1033
                  44444555555555555555555555555555555444 PP

  == domain 4  score: 15.4 bits;  conditional E-value: 6.5e-06
                  HHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......................................................STTTTT CS
         RGS   47 kkkakeIyneylapsspkelnidkklreelekrleke......................................................qpsrkl 89  
                   +k k+I+++ +  +s++e+ni k+ r+++ +r++                                                            ++
  EFC36875.1 1501 ETKRKNIVENVIFVGSAHEINIGKRERNQVLERVKRLlgnnpqrsevelqyfsnskqtlnkketesdeqsetstnkqksfssmnetstfimVDPINI 1597
                  5678899999999999999999999999999999998999999999999999999999999999999***********************99999** PP

                  THHHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS   90 feeaqeevfellekdsypkFlkselylrl 118 
                  f+ea   v + l++d +p Fl+s+ +l++
  EFC36875.1 1598 FDEALVTVKRQLKEDVFPLFLRSDRFLTF 1626
                  *************************9975 PP

  == domain 5  score: -3.6 bits;  conditional E-value: 5.3
                  TTSSTS-HHHHHHHHHHHCSSSTTTTTTH CS
         RGS   63 pkelnidkklreelekrlekeqpsrklfe 91  
                    e+nid++ r+   k+l+k  ++++l+ 
  EFC36875.1 1924 LYEINIDDQYRKV--KKLNK-MEMKELLT 1949
                  5689999999865..33334.45666655 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.8   0.00016      0.41      20      52 ..     417     449 ..     412     456 .. 0.84
   2 ?    0.4   0.3      0.22   5.6e+02      24      52 ..     958     986 ..     945     989 .. 0.75
   3 ?    1.7   0.7     0.084   2.2e+02      23      54 ..    1049    1080 ..    1041    1083 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00016
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-XX CS
       DivIC  20 kqlkqeiaalqaelaklkaeneeLeaevkdLks 52 
                  +l+++++++++++a+lk++ e+L+ +++ L++
  EFC36875.1 417 LSLQKQVDTITKDNAQLKDQMEKLKVRIEALEK 449
                 578899999999999999999999999998865 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.22
                 HHHHHHHHHHHHHHHHHHHHHHHHCC-XX CS
       DivIC  24 qeiaalqaelaklkaeneeLeaevkdLks 52 
                  e+++l ++++++ + ++ L+ e++ +++
  EFC36875.1 958 VEMQTLADKIDSMEKSIALLKTEIQYYSK 986
                 57777888888888888888888776655 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.084
                  HHHHHHHHHHHHHHHHHHHHHHHHHCC-XXXX CS
       DivIC   23 kqeiaalqaelaklkaeneeLeaevkdLksde 54  
                  ++ i++l + +++lk+e+e+ ++e ++L +++
  EFC36875.1 1049 NSFITDLYKSVDNLKKEEEKRKKEESKLAKEK 1080
                  55577777777777777777777777776555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1891  (0.105472); expected 358.6 (0.02)
Passed bias filter:                      640  (0.0356964); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.24u 0.34s 00:00:01.58 Elapsed: 00:00:00.57
# Mc/sec: 11215.08
//
Query:       EFC36876.1  [L=1083]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.9e-40  136.2  11.4    9.9e-40  136.2  11.4    2.5  4  Cation_ATPase_C  Cation transporting ATPase, C-terminus
    8.8e-38  129.6   1.4    8.8e-38  129.6   1.4    2.4  3  E1-E2_ATPase     E1-E2 ATPase
    1.3e-19   71.4   0.0    5.3e-19   69.3   0.0    2.1  1  Hydrolase        haloacid dehalogenase-like hydrolase
    7.4e-16   58.0   0.1      2e-15   56.6   0.1    1.8  1  Cation_ATPase    Cation transport ATPase (P-type)
    3.1e-08   33.2   0.6    1.3e-07   31.1   0.0    2.5  3  Cation_ATPase_N  Cation transporter/ATPase, N-terminus
    1.7e-05   24.7   0.2     0.0014   18.4   0.1    2.5  2  Hydrolase_3      haloacid dehalogenase-like hydrolase
  ------ inclusion threshold ------
      0.021   15.1   4.5         15    5.8   6.5    2.7  2  EI24             Etoposide-induced protein 2.4 (EI24)


Domain annotation for each model (and alignments):
>> Cation_ATPase_C  Cation transporting ATPase, C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.5       4.1     1e+04     139     152 ..     153     164 ..     147     193 .. 0.38
   2 ?   -1.8   0.2      0.86   2.2e+03      54      76 ..     335     357 ..     328     406 .. 0.49
   3 ?   -4.1   0.6       4.3   1.1e+04     110     136 ..     817     845 ..     806     851 .. 0.48
   4 !  136.2  11.4   3.9e-43   9.9e-40       2     181 ..     858    1051 ..     857    1052 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 4.1
  Cation_ATPase_C 139 qvlivyvpglnavf 152
                       ++i++v  l+ +f
       EFC36876.1 153 FAFISMV--LGLAF 164
                      2333333..22222 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.86
  Cation_ATPase_C  54 iliqgllqalvtllvffltlllf 76 
                      i+ +g+ +a+ t+++++l+++++
       EFC36876.1 335 IGKVGTAFAIGTVTILILAFWIK 357
                      54455555555555554444422 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 4.3
  Cation_ATPase_C 110 rsrreslfkfsglf..snkllllaillsl 136
                      rs +e++ kf  ++   n ++l+ +++s+
       EFC36876.1 817 RSIYENIRKFLVFQltVNVVALILTIVSA 845
                      55555555543333334433333333333 PP

  == domain 4  score: 136.2 bits;  conditional E-value: 3.9e-43
  Cation_ATPase_C    2 lplsaiqiLwinLvtDllpalaLaleppekdimkrpPrkkkepliskkmlrriliqgllqalvtllvffltlllfgisekenklssnyaqtm 93  
                        pls++q+LwinL++D+++alaLa+epp +++++r+P  +k++li+ +m++ i+  +++q+ v +++f+ + ++ g s +  + + +  +t+
       EFC36876.1  858 PPLSPVQMLWINLIMDTFAALALATEPPIPELLDRKPHGRKDSLITMRMWTFIAAESIFQLTVMFTLFYGATSFRGLSFSL-ARNDAEMRTI 948 
                       59******************************************************************8877755444333.223577**** PP

  Cation_ATPase_C   94 aFitlvlsqifnalnlrsrreslfkfsglfsnkllllaillslllqvlivyvpg...............lnavfgtaplsleewlialllal 170 
                       +F+++v++q+fn +n+r+ + ++  f+g+f++ +++++++++++lq++i+ + +                 ++ +t pl++++w+i++ +++
       EFC36876.1  949 IFNAFVFCQVFNQFNARKINFEYDIFRGVFKSFWFIGITIMIFILQIAIINFAYydpiliglgkndgltASNFTQTIPLNWYQWAITISIGF 1040
                       ******************999999999***********************996444556667777777688999****************** PP

  Cation_ATPase_C  171 vvllvdelvKl 181 
                       ++++++ lv++
       EFC36876.1 1041 ISIPYGFLVRF 1051
                       *****999887 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.4       1.7   4.2e+03     114     127 ..     175     188 ..     145     194 .. 0.38
   2 !  129.6   1.4   3.4e-41   8.8e-38       4     180 ..     212     420 ..     209     421 .. 0.91
   3 ?   -4.4   0.1       4.6   1.2e+04     116     138 ..     824     846 ..     819     857 .. 0.55

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.7
                   HHHHHHHHHHHHHH CS
  E1-E2_ATPase 114 kldklgkvlvpvvl 127
                   ++d+++ +++++++
    EFC36876.1 175 WIDSFAIYIAVAIV 188
                   23333333333333 PP

  == domain 2  score: 129.6 bits;  conditional E-value: 3.4e-41
                   --EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.EEE-TTTS---S-EE-G-TTEE-..TT-EEEE-EEEEEEEE-TTTSTTTTT CS
  E1-E2_ATPase   4 pptakvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa.evdesaLTGEslpvekekgdmvf..sGtvvvsgeakavVtatgedtelgki 97 
                   + ++kvirdg+  ++ ++++++GDiv++++gd +paDg  +e+++ + des++TGE   ++k++++ +f  sG++v +g+ k+ Vt +g  +e g+ 
    EFC36876.1 212 KVMVKVIRDGENFSVLTDDIRVGDIVEIEQGDGIPADGLCIESNHlKTDESVMTGEPDLIKKNTTELIFllSGCTVAEGSGKMLVTGVGVGSEWGRT 308
                   6789**********************************************************9999876559************************* PP

                   STTS----..----HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTT...........................HHHHHHHHHHHHHS-TTHHH CS
  E1-E2_ATPase  98 arlveeak..skktplqkkldklgkvlvpvvlliallvflialllgksla...........................eallralallvaaiPcaLpl 165
                    ++++ea+  +++tpl+ kldkl+  + +v++++a+ ++ i++l +                               ++++ al+++v+a+P++Lpl
    EFC36876.1 309 LQSLKEANeeQRETPLEAKLDKLAINIGKVGTAFAIGTVTILILAFWIKKlmytstwveasstfeetwqeknvvdvvKYFIIALTIVVVAVPEGLPL 405
                   *******98899*****************999999988877777333333445666678888888889999999*********************** PP

                   HHHHHHHHHHHHHHH CS
  E1-E2_ATPase 166 avplalalgarrlak 180
                   av++ala+++r+++k
    EFC36876.1 406 AVTIALAYSVRKMMK 420
                   *************97 PP

  == domain 3  score: -4.4 bits;  conditional E-value: 4.6
                   HHHHHHHHHHHHHHHHHHHHS-S CS
  E1-E2_ATPase 116 dklgkvlvpvvlliallvflial 138
                   +k+  +  +v +++++l+++ a+
    EFC36876.1 824 RKFLVFQLTVNVVALILTIVSAV 846
                   55555555555555555554443 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.3   0.0   2.1e-22   5.3e-19       3     210 .]     439     780 ..     437     780 .. 0.72

  Alignments for each domain:
  == domain 1  score: 69.3 bits;  conditional E-value: 2.1e-22
                 EEEEESBTTTBCHHHHHHHHHHHH...CHHHHHHHHHH...HHCHHHHHHHHHHHHH.....HHHH...HHHHHETTTE.................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxx...xxxxxxxxxxxxxxxx.....xxxx...xxxxxxxxxx.................... RF
   Hydrolase   3 tvvfDkdGTLttgepsvedvivsa...alalaaaletg...sehpigkalvaaakar.....sgal...tgfatfigrg.................... 67 
                  ++ Dk+GTLt  +++v++++        +l+ +l t      + i   +va  ka             +++at   +g                    
  EFC36876.1 439 NICSDKTGTLTLNQMRVTQAYFGDrffGEQLSSILLTLkspLLQVIIDGIVANSKANlvkgdD--NnknKEYAT---QGskteaalllllvkhlnqtid 532
                 6899***************77666566333444444445444456666677777777443221..111233333...3344556555665555555555 PP

                 ................HHHHTHHHHHHHH..HCHHHHHHHHHHHHHHCHHHHHH............................................. CS
                 ................xxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxx............................................. RF
   Hydrolase  68 ................ayaigkpewltal..dippdlgaaigsaqsqgrtvall............................................. 103
                                 +++      l+++   +++  g++ + + ++g ++++l                                             
  EFC36876.1 533 sykdrrnellseergsHLQLPFNSNLKRMstIVTNSEGETRYRLFTKGASEIVLklcsyhmasdgslrkmdsekeaemmkciedmanqglrticlayrd 631
                 444555555555555555555555555556556666666666666666666666********************************************* PP

                 ...........................TTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHHTT..........GGGE.SEEE CS
                 ...........................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..........xxxx.xxxx RF
   Hydrolase 104 ...........................qaralavftiadplkvkpeaaeavasLkaagievvlltgdnpetaeraanqlG..........ddyf.davi 164
                                            +    +++ i+dp  ++pe+  a+++ k+ gi v ++tgdn  ta+ +a+++G            +f + + 
  EFC36876.1 632 vnpevefssradeenylenidpvtleqDLVCIGIVGIKDP--LRPEVPAAIEQCKKSGITVRMITGDNILTAKYIARECGilskdgiaieGPTFrKMTP 728
                 *************************98889999*******..**************************************6655555555333322222 PP

                 EHHCES......STTTSHHHHHHHHHHHTSTGGGEEEEESSHHHHHHHHHTT CS
                 xxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 165 asdiet......vakpspegkvaaireLqgkpeevamVGDgvnDaaalaaAg 210
                 ++++e        a  sp +k  +++ L+ k++ va+ GDg nDa+al++A+
  EFC36876.1 729 EQIDEIlpklqvMARSSPTDKFILVKHLRKKGNVVAVTGDGTNDAPALKEAD 780
                 2222223345555555777777777777799*******************98 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.6   0.1   7.7e-19     2e-15       2      90 ..     489     591 ..     488     592 .. 0.84

  Alignments for each domain:
  == domain 1  score: 56.6 bits;  conditional E-value: 7.7e-19
  Cation_ATPase   2 lcN.saaf...sensekdevkllGnktEsALlvlaekl.........gldteelreetkkvqeipFnssrKrmsvvlkle.pekkvrlyvKGApei 83 
                    + N +a +   + n++++e+ + G+ktE+ALl l  k             +e l ee     ++pFns+ Krms++++++  e ++rl++KGA+ei
     EFC36876.1 489 VANsKANLvkgDDNNKNKEYATQGSKTEAALLLLLVKHlnqtidsykDRRNELLSEERGSHLQLPFNSNLKRMSTIVTNSeGETRYRLFTKGASEI 584
                    556466668888999****************99887777887777665555666666777799**************998899************* PP

  Cation_ATPase  84 ilkrCth 90 
                    +lk C++
     EFC36876.1 585 VLKLCSY 591
                    *****98 PP

>> Cation_ATPase_N  Cation transporter/ATPase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.1   0.0   5.3e-11   1.3e-07       4      69 .]      88     157 ..      85     157 .. 0.95
   2 ?   -3.9   0.0       4.7   1.2e+04      14      28 ..     780     794 ..     776     795 .. 0.77
   3 ?   -2.4   0.3       1.5   3.9e+03      55      69 .]     833     847 ..     824     847 .. 0.82

  Alignments for each domain:
  == domain 1  score: 31.1 bits;  conditional E-value: 5.3e-11
  Cation_ATPase_N   4 lsleevlekLetdlenGLtq....aeaaerlkkyGpNelkekkkkslwvkllkqftnplvilLlvaalvs 69 
                      +++++++++L+td ++G++     +   er   yG N+ +e++ k l++++++++++ + i+L++ a +s
       EFC36876.1  88 GGMSGLMRDLKTDAKRGIAWksnyQSYDERTNLYGLNVYPEPPAKGLFKIFFEALSDETHIILMIFAFIS 157
                      577899************88889********************************************998 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 4.7
  Cation_ATPase_N  14 etdlenGLtqaeaae 28 
                      ++ l+ GL+  ++a+
       EFC36876.1 780 DVGLSMGLSGTQVAK 794
                      556789***999986 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 1.5
  Cation_ATPase_N  55 tnplvilLlvaalvs 69 
                       n++ ++L ++++vs
       EFC36876.1 833 VNVVALILTIVSAVS 847
                      58999******9998 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.019        49      19      54 ..     675     710 ..     669     732 .. 0.87
   2 !   18.4   0.1   5.6e-07    0.0014     195     253 ..     752     811 ..     749     813 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.019
                  HHHHHHHHHHHTTSEEEEE-SS-HHHHHHHHHHCCC CS
  Hydrolase_3  19 ktkeaikklkekgikvviATGRslravlpvleelgl 54 
                  +  +ai+++k+ gi+v   TG ++ +++++++e g+
   EFC36876.1 675 EVPAAIEQCKKSGITVRMITGDNILTAKYIARECGI 710
                  66689*************************999885 PP

  == domain 2  score: 18.4 bits;  conditional E-value: 5.6e-07
                  HHHHCT--GGGEEEEESSGGGHHHHHHSSEEEEET.TS-HHHHHHSSEEE--GGGTHHHH CS
  Hydrolase_3 195 lakelnisleeviafGDgeNDieMLeaaglgvAmg.naseevkkaAdyvtksnnedGVak 253
                  l+k+l+ + + v++ GDg ND + L+ a++g  mg ++++ +k+a+d ++ + n ++++k
   EFC36876.1 752 LVKHLRKKGNVVAVTGDGTNDAPALKEADVGLSMGlSGTQVAKEASDIIILDDNFSSIVK 811
                  6799999999************************95667777888888888877777765 PP

>> EI24  Etoposide-induced protein 2.4 (EI24)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.023        58      54     114 ..     278     407 ..     146     418 .. 0.54
   2 ?    5.8   6.5    0.0057        15      14     113 ..     822     998 ..     811    1011 .. 0.62

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.023
                 H..............................................................HHHHHHHHHHHHHHH...HHHHHHHHHH.HHCCTTS CS
        EI24  54 p..............................................................lwlfplvalllaapf...ygllaekvekrhlglvks 87 
                 +                                                              ++ + +v++l+ a++   +   +  ve++  +++++
  EFC36876.1 278 LifllsgctvaegsgkmlvtgvgvgsewgrtlqslkeaneeqretpleakldklainigkvgtAFAIGTVTILILAFWikkLMYTSTWVEAS--STFEE 374
                 04444555555555555555555555666666666666666666666666666666666665567777888888888854433333333433..23444 PP

                 HH......HHHHHHHHHHHHHHHHHHHHHTTHH CS
        EI24  88 la......eslkslllllllllvllplliPvvg 114
                  +      + +k +++ l++++v+ p ++P+  
  EFC36876.1 375 TWqeknvvDVVKYFIIALTIVVVAVPEGLPLAV 407
                 444433335566666666666666665556443 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0057
                 TTHHHHHHHHHHHHHHHHHHHHHHH............................................................-..TTHHHHHHHHH CS
        EI24  14 kllallllplllnlllfllllvlll............................................................w..vllasllvlll 50 
                  ++++l+  l +n++ ++l +v ++                                                            w  + ++s++ l +
  EFC36876.1 822 NIRKFLVFQLTVNVVALILTIVSAVssafqhnssyrpplspvqmlwinlimdtfaalalateppipelldrkphgrkdslitmrmWtfIAAESIFQLTV 920
                 589999999999999999666666688999999999998888888555555555555555555555555555555555544444445544445555555 PP

                 HHHH...........HHHHH.......HHHHHHHHHHHHHHHHHHHH.HHCCTTSHHHHHHHHHHHHHHHHHHHHH.HHTTH CS
        EI24  51 lllp...........lwlfp.......lvalllaapfygllaekvekrhlglvkslaeslkslllllllllvllpl.liPvv 113
                 ++ +           +   +       + +++++a+++ +++++ ++r  ++  ++++++++ + ++ +++++++l +  ++
  EFC36876.1 921 MFTLfygatsfrglsF---SlarndaeMRTIIFNAFVFCQVFNQFNARKINFEYDIFRGVFKSFWFIGITIMIFILqI-AII 998
                 5555677777776542...13457777777777777777777777776654445555666666666666665555532.333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1083 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1172  (0.065369); expected 358.6 (0.02)
Passed bias filter:                      685  (0.0382063); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.69u 0.27s 00:00:00.96 Elapsed: 00:00:00.44
# Mc/sec: 7373.03
//
Query:       EFC36877.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       747  (0.0416643); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1199.88
//
Query:       EFC36878.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-18   65.8   0.1    6.8e-18   65.3   0.1    1.2  1  ParBc_2   Putative ParB-like nuclease


Domain annotation for each model (and alignments):
>> ParBc_2  Putative ParB-like nuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.3   0.1   3.8e-22   6.8e-18      74     164 .]      17     115 ..       5     115 .. 0.89

  Alignments for each domain:
  == domain 1  score: 65.3 bits;  conditional E-value: 3.8e-22
                 ...-EEEEEEEEE-TTS...-HHHHHHHHHHTT--B-B-TTS-B--....GGGS-SSGGG-EE-HHHHHHHHHHHTTSS--.-.SSTTHHHHHHHHHHT CS
     ParBc_2  74 gaekkvlvkvvadlsal...skeeFwekmeeekwvhlydekgepls....veelPkslgeleddpyRsLaafvrdaggfkk.ekatpfaeFlWadflrr 164
                 ++++ v+ +vv+d+s+     +e+Fw++m  +++++++de g++l+    +++lP+ + ++++dpyR L ++ r+ gg+ k ++++ f++F W++flr+
  EFC36878.1  17 AKNRYVIAQVVNDVSNNftsANEAFWNSMFGKGYAYPKDEYGKNLTtgmfIQQLPRDILSMRNDPYRALSYYDRSYGGYGKtDTSIYFVDFVWGNFLRE 115
                 467889999999999876445789*****************99988677789***************************9966789***********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       440  (0.0245412); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1542.81
//
Query:       EFC36879.1  [L=299]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1388  (0.0774165); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1847.88
//
Query:       EFC36880.1  [L=960]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.2e-23   82.8   1.0      5e-23   81.7   0.3    1.9  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    2.3e-06   27.6   5.6    2.3e-06   27.6   5.6    2.0  2  dCache_1       Cache domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0      0.61   5.5e+03      14      52 ..     167     201 ..     165     206 .. 0.68
   2 !   81.7   0.3   5.6e-27     5e-23       8     143 ..     477     622 ..     474     647 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.61
  Guanylate_cyc  14 adIvgftalssahspievvklLnelyarfdelldekkvy 52 
                     d++g  ++++      v++ Ln++  +f+e+++ + + 
     EFC36880.1 167 VDVNGNLSIAA----SLVLNNLNSIKPSFKEVIGVHVIF 201
                    55555544444....459999999999999999988743 PP

  == domain 2  score: 81.7 bits;  conditional E-value: 5.6e-27
  Guanylate_cyc   8 evtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevavesk..... 97 
                    e+ti+F+d+++ft++s+  s ++++ ++  +++ + + ++e ++  +k+iGd  m+++++p ++ ++ha+ +++ a+++++ l++ ++e +     
     EFC36880.1 477 EITIVFTDLANFTNISESLSIHNLLLVISRYFEVVTSNVQECGGIIDKYIGDGCMALFNTPyQPVTHHAEHACKAAIKIVKGLKKLNKEMEeiykm 572
                    89***********************************************************999********************999999668899 PP

  Guanylate_cyc  98 ...eglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkag 143
                       ++++ rvG++tG+ ++g iG   + +++  G+ vn+ sr+es+  ++
     EFC36880.1 573 klpTEISARVGVNTGSALIGNIGtHDRLNFTAVGDCVNVSSRLESLNRMY 622
                    999********************889*******************98764 PP

>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   5.6   2.6e-10   2.3e-06      40     205 ..      81     248 ..      28     286 .. 0.74
   2 ?   -3.0   0.0      0.57   5.1e+03     204     239 ..     852     884 ..     826     887 .. 0.75

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 2.6e-10
    dCache_1  40 pslqdlleepnraneasreslqallksilksnpdi...sgvylvdadGqv......iassdpssppnleg.........tddpadrdwykealaggggk 120
                 +s   +l        +s++++q+++ +++k +  +   +++y++  + ++                   +         t+dp+ r+wy+++ + ++gk
  EFC36880.1  81 SSTGPYLY-------LSQNIFQDQFSELFKNK-TFpasNNIYVFLTNDYFepylqkS------------NtvfrilynsTYDPRVRPWYTATESLEKGK 159
                 44555553.......36788888888888644.455668898887666663432220............123466667799***********999999* PP

    dCache_1 121 pvisdpyvdqtggkpvitiavpiyd.dsg..kfiGvlaadldldnlqdllsniklgetgyvfivdsdGniiahpdkdl..lgknlrdelk 205
                 pv+s++ vd + g++ i+ +  + + +s    f+ v+++ + +  +q +l  +  + +  + +++++Gn++++++ ++    +nl+ ++ 
  EFC36880.1 160 PVWSNVFVDVN-GNLSIAASLVLNNlNSIkpSFKEVIGVHVIFKKIQTYLLGLYSYTNNLMILMENNGNLLTSNEDSFplTYSNLSRVNI 248
                 *******9988.99888888888875433558899*************6666655777899999*********99555544444444332 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.57
    dCache_1 204 lkaqealekalakiesgvssvklngeeylvayapip 239
                 +   e le  l+++e ++ +v++n+++ l++   i+
  EFC36880.1 852 K---ERLELTLMEHEAKKRKVQINKKRSLLTALSID 884
                 2...57889999999999999999999988866665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (960 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       855  (0.0476881); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.23s 00:00:00.83 Elapsed: 00:00:00.41
# Mc/sec: 7012.85
//
Query:       EFC36881.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      4e-22   78.4   0.7    1.6e-19   70.0   0.4    2.5  2  DSPc             Dual specificity phosphatase, catalytic doma
    2.2e-06   27.9   0.0    5.7e-06   26.6   0.0    1.7  1  Init_tRNA_PT     Rit1 DUSP-like domain
    0.00015   21.9   0.0    0.00039   20.6   0.0    1.7  1  PTPlike_phytase  Inositol hexakisphosphate
  ------ inclusion threshold ------
      0.011   15.7   0.0       0.02   14.9   0.0    1.4  1  Y_phosphatase3   Tyrosine phosphatase family
      0.029   13.9   0.1       0.06   12.9   0.1    1.5  1  Y_phosphatase    Protein-tyrosine phosphatase
      0.033   13.8   0.4       0.15   11.7   0.2    2.1  2  Y_phosphatase2   Tyrosine phosphatase family


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0024       7.2       1      38 [.      54      89 ..      54     118 .. 0.74
   2 !   70.0   0.4   5.4e-23   1.6e-19      33     131 ..     132     233 ..      97     235 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0024
                EEEEECCHHC.HHHHHHHTCSEEEEESSSSSECECCTTT CS
        DSPc  1 lylgskstas.lallsklgitlvinvtkevpnanalkks 38
                ++lgs+ +a+ ++  + + i++v+nv++ ++  +  +k+
  EFC36881.1 54 VFLGSQWEAKdPDWFQTHRISHVLNVSTLQNT-F--QKK 89
                79********9****************55443.2..222 PP

  == domain 2  score: 70.0 bits;  conditional E-value: 5.4e-23
                 ECCTTTTSEEEEECCESSTTSCCGGGHHHHHHHHHHH..HHTT-EEEEEESSSSSHHHHHHHHHHHHHHTSCHHHHHHHHHHHS.TT-SSTHHHHHHHH CS
        DSPc  33 nalkkseieklripvedehetkiskyleeavefidka..kqkgkkvlVHCqaGisRSatliiaYlmktknlslneayeflkerr.paispnagfirqLl 128
                   +++ + ++l+i v+d+++ +++ky+e++++f+++a   +   +vl+HC+ G sRS t+++ + m ++ lsl eay++++++  ++ + n gf+ qL+
  EFC36881.1 132 SGKQQVHVNYLKINVDDSTDVNVRKYFEKVIDFVRDAleGSPTSNVLIHCKEGKSRSVTMMLVFGMAYFDLSLYEAYKHFENKTfNRSRINLGFQLQLM 230
                 3357889****************************996556789************************************9998788888999****** PP

                 HHH CS
        DSPc 129 eye 131
                 +ye
  EFC36881.1 231 NYE 233
                 *98 PP

>> Init_tRNA_PT  Rit1 DUSP-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.6   0.0   1.9e-09   5.7e-06      15      74 ..     152     213 ..     132     228 .. 0.79

  Alignments for each domain:
  == domain 1  score: 26.6 bits;  conditional E-value: 1.9e-09
  Init_tRNA_PT  15 knLrtalpkivdfvrkrlsedkkkkilvacetGkdlsvgvaLailcklfdda..klseeqse 74 
                    n r+ ++k++dfvr+ l+ + ++++l++c++Gk+ sv ++L+  +++fd +  ++ ++ ++
    EFC36881.1 152 VNVRKYFEKVIDFVRDALEGSPTSNVLIHCKEGKSRSVTMMLVFGMAYFDLSlyEAYKHFEN 213
                   578999**************999**************************6554322233333 PP

>> PTPlike_phytase  Inositol hexakisphosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   1.3e-07   0.00039      90     154 ..     129     197 ..      71     199 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.3e-07
                      -HHHHHHHTT-EEEEEEE-TTS---.HHHHHHHHHHHHTS-T...T-EEEEE-SSSSHHHHHHHHHHHH CS
  PTPlike_phytase  90 yerelaeelslrYaRipitdekape.eedfdalvsilkeape...ktalvfnCqmGrgRTTtamviatL 154
                      +    +++++++Y  i + d++  +  ++f+++++++++a e   ++ ++++C+ G+ R+ t+m ++ +
       EFC36881.1 129 TTLSGKQQVHVNYLKINVDDSTDVNvRKYFEKVIDFVRDALEgspTSNVLIHCKEGKSRSVTMMLVFGM 197
                      5555678999***********99973689***********66688999****************98776 PP

>> Y_phosphatase3  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   0.0   6.8e-06      0.02      78     141 ..      81     194 ..      25     201 .. 0.59

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 6.8e-06
  Y_phosphatase3  78 v........................................eeaaeeekeeeeaeetlaelYrelle......sakkayrkvfealad.ee.... 121
                     +                                        +  + +++++ +++++++  Y ++        + +k ++kv++ ++d  e    
      EFC36881.1  81 TlqntfqkkplyysnlstnsssdpentnpnimmmnsmssggS-HSVNKNTTLSGKQQVHVNYLKINVddstdvNVRKYFEKVIDFVRDaLEgspt 174
                     244444444445555555666666666666666666554321.3455556666666777777776657877776677777777777776225888 PP

  Y_phosphatase3 122 .pvlfHCtaGKDRTGvlaall 141
                       vl+HC  GK R  v+++l+
      EFC36881.1 175 sNVLIHCKEGKSRS-VTMMLV 194
                     899*********97.555555 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1     2e-05      0.06     139     190 ..     145     194 ..      69     202 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2e-05
                    EESSS-SSSSGSCCHHHHHHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHH CS
  Y_phosphatase 139 qytnWpdhgvpesaksllklirkvekskeaksgpvvVhCsaGvgRtgtfval 190
                     + + +d +v +  +++++++r++ + +   ++ v++hC++G +R+ t++++
     EFC36881.1 145 NVDDSTDVNVRKYFEKVIDFVRDALEGS--PTSNVLIHCKEGKSRSVTMMLV 194
                    444556888999999********99999..89**************999875 PP

>> Y_phosphatase2  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.26   7.9e+02      21      58 ..      38      74 ..      36      98 .. 0.80
   2 ?   11.7   0.2   4.9e-05      0.15      48     108 ..     129     191 ..      93     250 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.26
                    -HHHHHHHHHCT-SEEEE-SSS---HHHHHHHHHCT-E CS
  Y_phosphatase2 21 rasnfsflksLkLktiislspeeesqdelqfleeekik 58
                    ++sn+s+l +L++   + l  + e++d+  f ++++i 
      EFC36881.1 38 KPSNYSHLAELEIYPRVFLGSQWEAKDPDWF-QTHRIS 74
                    5789999999999999999999888888888.555554 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 4.9e-05
                     HHH.HHHHCT-EEEE-------GGG----HHHHHHHHHHHH-.GGG-SEEEE-SSSSSHHHHH CS
  Y_phosphatase2  48 elq.fleeekiklyhiaiesnkeelveiksdllkkalkllln.kenypvllhckrGkhrtglv 108
                     ++  + ++ ++++++i+++++ +  v    +++   ++  l+     +vl+hck+Gk r  ++
      EFC36881.1 129 TTLsGKQQVHVNYLKINVDDSTDVNVRKYFEKVIDFVRDALEgSPTSNVLIHCKEGKSRSVTM 191
                     333477899**************888888788887777766625689**********985443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       730  (0.0407162); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 2740.70
//
Query:       EFC36882.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       566  (0.031569); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1172.05
//
Query:       EFC36883.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.5e-37  128.9   0.0      3e-37  128.6   0.0    1.1  1  FAD-oxidase_C  FAD linked oxidases, C-terminal domain
  ------ inclusion threshold ------
      0.025   14.7   0.2      0.054   13.6   0.0    1.7  2  BBE            Berberine and berberine like


Domain annotation for each model (and alignments):
>> FAD-oxidase_C  FAD linked oxidases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.6   0.0   3.3e-41     3e-37       2     249 ..      54     318 ..      53     319 .. 0.95

  Alignments for each domain:
  == domain 1  score: 128.6 bits;  conditional E-value: 3.3e-41
                    -SEEEEEEEEESSHHHHHHHHHHHHHHT---SEEEEE-HHHHHHHHHTS-SS...................TTS-TTT-EEEEEEEEE-HHHHHHH CS
  FAD-oxidase_C   2 pearavalvafpsfeaavkavreiaqagiipaalelmdkkaldlveatkgak...................kglpdeeealllvefegddeeeaee 78 
                    pe +++++v +p+fea+v++++e+  +++  a+++l+d+ ++++++++k+++                    g+++e+ +++++ feg++++ +++
     EFC36883.1  54 PECQVYGSVLVPDFEAGVACLHEVSNRRVATASIRLIDNSQFQFGQSLKPKQeskleglsdwfkglyvtkvCGFDKEKMCVITLLFEGSQSDIDRQ 149
                    78899******************************************************************************************9 PP

                    HHHH.HHHHTTT-EEEEE..........ETGGGGGGGGHHHHHHHHHCTTEEEEEEEEEEEHHHHHHHHHHHHHHHHHHH..EEEEEEEEEETTEE CS
  FAD-oxidase_C  79 elea.lveaileatgaadvlvaqdeaeaealwkaRkaalpylrdallkagvavlseDtsvPvsrladlvrdikalldkyg..levvlfgHagdgnl 171
                    +    +++a+ ++ +a+         ea  + ++ +++++ylrd + +++ + +s++ts P+sr+  ++++     ++    ++ ++++++++ ++
     EFC36883.1 150 QKIIyDITAKYGGLVAGA--------EAGYRGYLLTYVIAYLRDYGFNYYFMSESFETSAPWSRVVPIIKKKVPSNEDVPtpWVSARVTQVYETGA 237
                    999999999999999998........66699**********************************9999988888888879*************** PP

                    EEEEEEEEE..--TT--THHHHHH....HHHHHHTT-----------------------THHHHHHHHHHHH-TT--BSTT- CS
  FAD-oxidase_C 172 hlyilfdladeaeeeraeklvdev....vdlavelgGsisgEHGvGldkkaylerekgeeglalmrriKaalDPkgiLNPgk 249
                    ++y+++ +  ++ ++++ k++ e+    +d+++  gGs+s++HGvG+ +k+++ + +g++g+++++++K+  DP++++  g+
     EFC36883.1 238 CIYFYYGFIFRGLQDPI-KAFSEIeaeaRDEILLQGGSLSHHHGVGKLRKEWMSQVVGDQGVEILKKLKNNVDPDNLFGNGN 318
                    ********999999988.5555555777**************************************************9886 PP

>> BBE  Berberine and berberine like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.3   0.3         2   1.8e+04      12      19 ..     184     191 ..     175     192 .. 0.75
   2 ?   13.6   0.0     6e-06     0.054      23      41 ..     298     316 ..     265     318 .. 0.81

  Alignments for each domain:
  == domain 1  score: -4.3 bits;  conditional E-value: 2
                 HHHHHHHH CS
         BBE  12 kewgerYF 19 
                 +++g +Y+
  EFC36883.1 184 RDYGFNYY 191
                 37777887 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 6e-06
                 HHHHHHHHHHH-TT--S-- CS
         BBE  23 ferLvkvKtkyDPdNvFrn 41 
                  e L k+K+ +DPdN+F n
  EFC36883.1 298 VEILKKLKNNVDPDNLFGN 316
                 788**************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       522  (0.0291148); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2098.18
//
Query:       EFC36884.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1754  (0.0978303); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 2146.86
//
Query:       EFC36885.1  [L=513]
Description: hypothetical protein NAEGRDRAFT_59903 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.4e-05   23.2   1.6    0.00075   19.8   0.2    3.4  4  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.2   4.2e-08   0.00075       2     112 ..      23     178 ..      22     184 .. 0.64
   2 ?   -3.8   0.0      0.85   1.5e+04      51      74 ..     283     304 ..     279     307 .. 0.75
   3 ?   -2.2   0.0      0.27   4.9e+03      66      81 ..     469     484 ..     441     503 .. 0.57
   4 ?   -2.5   0.0      0.34     6e+03      11      23 ..     493     505 ..     482     510 .. 0.65

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 4.2e-08
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS....................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka....................keqeelkkkakeIyneylapsspkelnidkklreelekrl 80 
                 +e+ll  +  r+ Fr Fl+  ++ee l++ +a++ ++++                    k+   l+++ ++I+n++  ++s +  + ++  +   ++ l
  EFC36885.1  23 FEELLRAPEARENFRGFLKLVHCEEPLQLIDAIDSYRTEhkklidniddsasdfdfqgfKKILLLVNQLENIVNTFGLEDSIE--KFSHYYMGAWTRTL 119
                 799************************************88888888888888888888566666666666666664333222..22222222222222 PP

                 CSS...........................STTTTTTHHHHHHHHHHHHHHHHHHHHTS CS
         RGS  81 eke...........................qpsrklfeeaqeevfellekdsypkFlks 112
                 +                              + ++++e+++++    l+ d +p++ +s
  EFC36885.1 120 NLYhlvtlklesisnsnktnnkqifeileiLNPSNILEDVETKAILDLKYDEFPRYARS 178
                 22233334444444444666666666666655566666666666666666666666666 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 0.85
                 HHHHHHHTSTTSTTSSTS-HHHHH CS
         RGS  51 keIyneylapsspkelnidkklre 74 
                 ++++ +y+  ++++  ++d+ l++
  EFC36885.1 283 EDVWATYC--DMNTRFKLDHTLMK 304
                 56788888..77788888888876 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.27
                 STS-HHHHHHHHHHHC CS
         RGS  66 lnidkklreelekrle 81 
                 ++idk++++   k+++
  EFC36885.1 469 ISIDKSMVNDHFKYFT 484
                 4555555554444444 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 0.34
                 HHHHHHHHHHHTT CS
         RGS  11 grslFreFlesef 23 
                  r+ +r++l++++
  EFC36885.1 493 NRKWYRDYLRKKN 505
                 4666777777754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (513 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       711  (0.0396564); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.36s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2944.13
//
Query:       EFC36886.1  [L=375]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-07   31.2   0.2     0.0033   17.1   0.0    2.9  4  DUF4116         Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.03   14.9  56.7    1.8e+04  -18.4  56.7    3.2  1  KRTAP           Keratin-associated matrix
        1.4    9.0  53.9    1.8e+04  -18.5  53.9    3.1  1  Keratin_2_head  Keratin type II head


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0013       7.6      31      48 ..     168     185 ..     151     189 .. 0.67
   2 !   10.9   0.1   4.9e-05      0.29       6      48 ..     168     210 ..     164     211 .. 0.93
   3 !   14.3   0.0   4.1e-06     0.024       4      46 ..     191     233 ..     189     234 .. 0.85
   4 !   17.1   0.0   5.6e-07    0.0033       1      38 [.     213     252 ..     213     261 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0013
     DUF4116  31 lkAvkqngtalsyaseeL 48 
                 + A++ +++++ y+++ +
  EFC36886.1 168 MHAIELDPKCYAYVPDYI 185
                 556667777777776655 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 4.9e-05
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 ++a++ +++++ y+++ +k  + i++k   +n++    +++eL
  EFC36886.1 168 MHAIELDPKCYAYVPDYIKMMRHIAKKVFIRNPSLGTLIPKEL 210
                 89********************************999999998 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 4.1e-06
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 i+++++ +n+s  + +++eL  D ++v+   k++ ++l yas+
  EFC36886.1 191 IAKKVFIRNPSLGTLIPKELLEDTDFVMDVYKSSQSILFYASP 233
                 5666666777766779*************************97 PP

  == domain 4  score: 17.1 bits;  conditional E-value: 5.6e-07
     DUF4116   1 DrEivleavkkngsalkylsee..LknDkeivlkAvkqng 38 
                 D ++v+ + k+  s+l y+s+   + +D+ ++++A+k++g
  EFC36886.1 213 DTDFVMDVYKSSQSILFYASPIgkWWSDRVFMIEALKSDG 252
                 669*****************7755888***********99 PP

>> KRTAP  Keratin-associated matrix
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -18.4  56.7         3   1.8e+04      40      41 ..     316     323 ..     252     375 .] 0.51

  Alignments for each domain:
  == domain 1  score: -18.4 bits;  conditional E-value: 3
       KRTAP  40 G......g 41 
                 G       
  EFC36886.1 316 GlglglgL 323
                 01111110 PP

>> Keratin_2_head  Keratin type II head
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -18.5  53.9         3   1.8e+04     100     126 ..     302     330 ..     243     375 .] 0.46

  Alignments for each domain:
  == domain 1  score: -18.5 bits;  conditional E-value: 3
  Keratin_2_head 100 gvGggfGggggl.vGgggfGg.ggfGg.gG 126
                     g+G+g+G g gl +G  g+G   g+G+  G
      EFC36886.1 302 GLGLGLGLGLGLgLGL-GLGLgLGLGLgLG 330
                     1111111111110010.1110001110111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       403  (0.0224776); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 2139.46
//
Query:       EFC36887.1  [L=116]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       806  (0.0449551); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.50
# Mc/sec: 697.16
//
Query:       EFC36888.1  [L=335]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.016   15.1   0.9      0.031   14.2   0.9    1.6  1  F-box_4     F-box
       0.08   12.8   0.5       0.15   12.0   0.5    1.4  1  F-box-like  F-box-like
       0.11   12.6   1.3       0.15   12.2   0.5    1.7  2  SPRY        SPRY domain
       0.24   11.6   6.5      0.078   13.2   2.9    1.9  2  Abi_2       Abi-like protein


Domain annotation for each model (and alignments):
>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.9   6.9e-06     0.031       5      41 ..       5      42 ..       1     122 [. 0.61

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 6.9e-06
     F-box_4  5 LssLPlevlqhi.aslLDsfsLsqLslvskllrevcss 41
                ++ +P+evl+ + +s+LD  sL++L +++++lr +  s
  EFC36888.1  5 INAIPTEVLEDVvCSFLDVKSLFSLLKINRSLRSILLS 42
                6789*****986279******************98432 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.5   3.3e-05      0.15       2      43 ..       6      48 ..       5      52 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3.3e-05
  F-box-like  2 srLPdEiLlqIF.syLppsdLlrlalVCrrWrrvaldtplLWr 43
                + +P+E+L ++  s+L+ ++L +l    r+ r++ l+  ++W 
  EFC36888.1  6 NAIPTEVLEDVVcSFLDVKSLFSLLKINRSLRSILLSSSSVWE 48
                689*******99789**********************999997 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       2.4   1.1e+04      79      97 ..     155     173 ..     151     176 .. 0.70
   2 ?   12.2   0.5   3.4e-05      0.15       2     107 ..     191     313 ..     190     323 .. 0.58

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 2.4
                 EEEEEETTEEEEEEEESTT CS
        SPRY  79 elsFtkngknlgvaFrnvr 97 
                 ++ Ft+n ++     ++++
  EFC36888.1 155 SVDFTNNDHCFHSCHKHLN 173
                 6789999887766666655 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 3.4e-05
                 EEEEEEET.....CCTSSEEEEEE......EETTSSSSSTSSSTSSTTE.EEEETETTEEEEETESCEEEESSSSTTSEEEEEEETTTT...EEEEE.E CS
        SPRY   2 hyfevkiq.....saeggsisvGl......ateqtdlsdksgegddrgs.wglcgdngtrtsaeqskaygkqparegdviGvalDleeg...elsFt.k 84 
                 + + ++++     + +   i++G+      ++++t+   + + g+++   +g+c ++ +++   q +    ++ +egdviGv +  + g    ++F+  
  EFC36888.1 191 YFWAIHLTnyhneGSNAWGIVIGIddkenqSRNSTSSAIHYYIGKESSNgVGYCVHSHSKSYRGQCEYSRANNNQEGDVIGVEFYQK-GldvNMKFYtC 288
                 667777776633223333467888666666555555555555477776688888888888644444444445889*******76333.21223444413 PP

                 TT.EEEEEEEESTTTS.SEEEEEEE CS
        SPRY  85 ng.knlgvaFrnvrga.elfPvvsl 107
                  g   + + ++ +++   + P+vs+
  EFC36888.1 289 FGdSIVDYQYSLAKDVvGFQPAVSI 313
                 4445556666666665777777776 PP

>> Abi_2  Abi-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   2.9   1.7e-05     0.078      30     132 ..      22     131 ..      17     173 .. 0.67
   2 ?   -1.0   0.2      0.41   1.8e+03      71     113 ..     190     232 ..     142     255 .. 0.58

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.7e-05
       Abi_2  30 tfeeilalykfDrkLrslllkaieriEialrtaiayels......kedeeaylds........dnfkkkkkkkkekkk..liekiekeierskesfikh 112
                 +++ +++l k++r Lrs+ll+  +  E++lr+ i ++        k      l+         d+f+ + k+ k   +  + + i++ +  ++e+f k 
  EFC36888.1  22 DVKSLFSLLKINRSLRSILLSSSSVWENSLRSMIKHQEDefklseK-----ELNVgrvmrklfDEFSLQIKEFK---EkdTMSGIMNYL--QEEEFRKV 110
                 678999****************************777666544331.....22224445433333322222222...233335555555..33446666 PP

       Abi_2 113 ykkky.nkeiPlWvlvevlsf 132
                 y +++ n+++ l  l++++sf
  EFC36888.1 111 YDDHQeNAYFFLVCLFKTFSF 131
                 666552245555555555555 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.41
       Abi_2  71 deeayldsdnfkkkkkkkkekkk......liekiekeierskesfikhy 113
                  +++  + +n++++ ++            + ++ e++ ++s++s+i++y
  EFC36888.1 190 RYFWAIHLTNYHNEGSN-----AwgivigI-DDKENQSRNSTSSAIHYY 232
                 34444444455443332.....12223322.333333323334455444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       933  (0.0520386); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2002.42
//
Query:       EFC36889.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-10   40.0  13.6    4.8e-10   39.7  13.6    1.1  1  GtrA      GtrA-like protein
  ------ inclusion threshold ------
      0.041   13.8  15.5      0.055   13.4  15.5    1.1  1  DUF4271   Domain of unknown function (DUF4271)


Domain annotation for each model (and alignments):
>> GtrA  GtrA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.7  13.6   5.4e-14   4.8e-10       4     117 .]      12     130 ..       9     130 .. 0.93

  Alignments for each domain:
  == domain 1  score: 39.7 bits;  conditional E-value: 5.4e-14
        GtrA   4 ivGvlgtlvdlallllllel.....lglsyllAnaiafivailfnFilnrrwtFkdrekakllkqflkFvlvsllglllnllilwllveklgleallak 97 
                 +  ++gt++ ++++ +l+++      + +  l  ++++ ++i++++ l+ r++F +r++++ ++ +++ ++v+++++++++++ ++lv ++++ ++ a 
  EFC36889.1  12 VSTIIGTFIFFLFYHFLYQFitaedESTKSSLCWLLSYSLSIWCQYELHCRIVFGKRSNSEYWRSLIRTYFVYGISMVFSTILNYMLVGYFKVGHTYAW 110
                 556788888888888888889999999999********************************************************************* PP

        GtrA  98 lvgiivalvlnyvlsklfvF 117
                 ++++i++ +lny++ ++f+F
  EFC36889.1 111 ILSLILVGILNYFTVSKFAF 130
                 *************9999987 PP

>> DUF4271  Domain of unknown function (DUF4271)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4  15.5   6.2e-06     0.055      53     172 ..       7     126 ..       3     133 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 6.2e-06
     DUF4271  53 flllltclllglllylllsefgslfgsylassllllliiflilllylllKlllykllgwlFfdkkkirqwifsylsylsllgl.llfplv...lllvyf 147
                 ++l++++ ++g ++++l+ +f ++f +    +  +    ++ ll y l  ++ y l   + f k+ ++++  s++ ++++ g+ ++f  +   +l+ yf
  EFC36889.1   7 VFLFQVSTIIGTFIFFLFYHFLYQFIT---AEDESTKSSLCWLLSYSLSIWCQYELHCRIVFGKRSNSEYWRSLIRTYFVYGIsMVFSTIlnyMLVGYF 102
                 578899999999999999999999997...44455555556667777777777777777777777777776666666666666444444311268889* PP

     DUF4271 148 plssqillililiilllikllllly 172
                 +  +++++il li+++++++++ + 
  EFC36889.1 103 KVGHTYAWILSLILVGILNYFT-VS 126
                 *************999999988.44 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       763  (0.0425568); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 913.50
//
Query:       EFC36890.1  [L=326]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00015   21.6   0.0    0.00026   20.8   0.0    1.3  1  Phage_integrase  Phage integrase family


Domain annotation for each model (and alignments):
>> Phage_integrase  Phage integrase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   1.4e-08   0.00026      34     169 ..     161     307 ..     148     309 .. 0.82

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 1.4e-08
                      T--HHHHTT-BGGG.EECTTTEEEEE...........EEECSSSSEEEEECT...HHHHHHHHHHHHHHCHCCTTTSBSSBETTSSB--HHHHH CS
  Phage_integrase  34 GlRisEllsLrvkd.ldlengvilvh...........eregKgskeravpls...eealellkellskaleeaeksellfaskrgkplsrqtvr 112
                       +R +El++L+++   +l+ng i+++           e+ ++  k    +l       ++ll +++++    ++ ++ lf  +++   ++++v+
       EFC36890.1 161 FARPGELARLKWGYvTKLRNGNIKLDlsghktdffllEKPITIDK----HLEnpsVCPVKLLFDYMNTVQHFKKADSPLFSLQDNIFFNTEDVS 250
                      57999********97889999999984444444444333333333....3333335678999999999999999999***************** PP

                      HHHHHHHHHCT-SSC--TTHHHHHHHHHHHHHCTSHHHHHHHHT-SSCCHHHHHHCC CS
  Phage_integrase 113 kafkraveeagiekpltpHtlRhsfataLleagvdlrvvqkllGHssisttqiYthv 169
                      + +k+a    + e  +++H+lR  + t+ + +g++++ + +   H+++++ q Y + 
       EFC36890.1 251 QLIKNAMFSVDSEITVSGHSLRIGATTESIIKGIPTQDIIMGTRHKDVKSLQPYQRQ 307
                      *********999999*************************************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (326 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       455  (0.0253779); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2197.78
//
Query:       EFC36891.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.13   12.6   1.7       0.27   11.6   0.1    2.3  3  HCMV_UL139  Human Cytomegalovirus UL139 protein
       0.82    8.2  12.2        0.7    8.4  11.5    1.3  1  Macoilin    Macoilin family


Domain annotation for each model (and alignments):
>> HCMV_UL139  Human Cytomegalovirus UL139 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.54   4.9e+03      57      80 ..      31      54 ..      29      65 .. 0.69
   2 ?   11.6   0.1     3e-05      0.27      51     101 ..     118     168 ..     110     178 .. 0.89
   3 ?   -2.9   0.0      0.97   8.7e+03      37      62 ..     305     329 ..     302     336 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.54
  HCMV_UL139 57 dakyvaisrdlrslkgeveeaerk 80
                +a+++   ++lr+lk  ++ a+r 
  EFC36891.1 31 KARKQQAAKKLRKLKAMSPVANRN 54
                678888888888888765554443 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 3e-05
  HCMV_UL139  51 seidaldakyvaisrdlrslkgeveeaerkeeereryyeakrkemeeflpm 101
                  +i a++a+ + ++  lr++ g+++e+ +k +ere    + ++++e+ +p 
  EFC36891.1 118 HDIMAIKAQMQEMIGVLRTVTGNISELTKKVQEREEESDDDFVNPEAISPE 168
                 578899999999***********************9999999999998875 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 0.97
  HCMV_UL139  37 rkiadlnsrilslrseidaldakyva 62 
                 r i   ns  +++ se+ ++++ y+ 
  EFC36891.1 305 RYI-STNSFETAAESELHNIRTTYHY 329
                 555.4666667888888888888875 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4  11.5   7.8e-05       0.7     235     351 ..       3     120 ..       1     338 [. 0.47

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 7.8e-05
    Macoilin 235 sknnhslnkkdsslklpeleyrekkksakssrsdskkkhehn...esvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnkn 330
                 +k+ ++ ++++s ++lp +e +  ++  k+++++++kk ++    + v ++ ++k+ ++  s++  l+   s+  +s+ll ++   ++ss++ sssn++
  EFC36891.1   3 AKKPQDIDSSSSDEDLPAVEVEYPTTPVKARKQQAAKKLRKLkamSPVANRNKRKQSTSVSSSNSALYDGISTVVSSSLLSNSTLLDSSSTAPSSSNNS 101
                 566667777777777777776666555555555554444333333333333333333333333334444444444445555555444444444443333 PP

    Macoilin 331 skkasagsagssnssskkhse 351
                 s+++s+   +s +sss +h+ 
  EFC36891.1 102 SSSNSG--RDSFTSSSSEHDI 120
                 333333..2222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1489  (0.0830498); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 2277.73
//
Query:       EFC36892.1  [L=548]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.5e-52  170.5  74.7    0.00029   20.6   0.2   16.1 16  LRR_6         Leucine Rich repeat
    4.1e-47  157.8  59.3      1e-11   44.4   4.6    7.1  6  LRR_8         Leucine rich repeat
    1.7e-40  136.3  65.4    7.6e-07   29.4   0.5   10.0 10  LRR_4         Leucine Rich repeats (2 copies)
    3.6e-13   48.1  49.3        1.6    9.5   0.2   14.1 14  LRR_1         Leucine Rich Repeat
    4.3e-13   49.1  14.1    4.7e-06   26.2   0.1    4.7  5  LRR_9         Leucine-rich repeat
      7e-09   35.7   0.2     0.0019   18.2   0.0    4.2  4  LRR_5         BspA type Leucine rich repeat region (6 copies)
    1.6e-08   34.3   0.0    3.4e-08   33.2   0.0    1.5  1  F-box-like    F-box-like
    2.8e-05   23.9   0.0    6.7e-05   22.7   0.0    1.6  1  F-box         F-box domain
  ------ inclusion threshold ------
        1.4    9.1   7.6         18    5.6   0.1    4.6  5  Peripla_BP_7  Periplasmic binding protein domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1      0.19   3.8e+02       4      16 ..     116     128 ..     113     135 .. 0.88
   2 !   20.3   0.7   1.8e-07   0.00036       2      22 ..     138     158 ..     137     160 .. 0.90
   3 !   20.3   0.1   1.8e-07   0.00036       2      23 ..     162     183 ..     161     184 .. 0.91
   4 !   20.6   0.6   1.5e-07   0.00029       2      24 .]     186     208 ..     185     208 .. 0.92
   5 !    6.2   0.4    0.0064        13       2      23 ..     210     231 ..     209     231 .. 0.93
   6 !   20.6   0.2   1.5e-07   0.00029       4      20 ..     236     252 ..     233     256 .. 0.88
   7 !   17.3   0.3   1.7e-06    0.0034       4      24 .]     260     280 ..     257     280 .. 0.93
   8 ?    0.2   0.2      0.53     1e+03       4      11 ..     284     291 ..     282     291 .. 0.88
   9 !    9.0   0.1    0.0008       1.6       3      24 .]     299     320 ..     297     320 .. 0.92
  10 !    8.6   0.2    0.0011       2.1       3      17 ..     323     337 ..     321     344 .. 0.87
  11 !   17.3   0.0   1.8e-06    0.0035       4      23 ..     348     367 ..     345     368 .. 0.90
  12 !   19.3   0.1     4e-07    0.0008       3      24 .]     371     392 ..     369     392 .. 0.92
  13 !   12.8   0.3   4.7e-05     0.093       3      17 ..     395     409 ..     393     411 .. 0.92
  14 !   18.4   0.1   7.5e-07    0.0015       3      24 .]     418     439 ..     416     439 .. 0.91
  15 !   19.3   0.9     4e-07    0.0008       3      24 .]     442     463 ..     440     463 .. 0.93
  16 ?    5.4   0.1     0.011        22       4      19 ..     467     482 ..     464     486 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.19
       LRR_6   4 hLteLdLsgNdIg 16 
                 +Lt LdL  N+I 
  EFC36892.1 116 NLTQLDLCRNKIK 128
                 79********997 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 1.8e-07
       LRR_6   2 nthLteLdLsgNdIgDeGaea 22 
                  t+L++L+L +N+Ig++Ga+ 
  EFC36892.1 138 LTNLKKLNLGHNEIGNDGAKH 158
                 589****************97 PP

  == domain 3  score: 20.3 bits;  conditional E-value: 1.8e-07
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  thLt+LdL +N+Ig  Ga+ L
  EFC36892.1 162 LTHLTALDLFDNGIGPNGAQRL 183
                 69*****************987 PP

  == domain 4  score: 20.6 bits;  conditional E-value: 1.5e-07
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  t+Lt L+L  N+IgD+Gae ++
  EFC36892.1 186 LTNLTQLNLGNNEIGDAGAEHIS 208
                 589*****************986 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.0064
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  t+Lt L+L+  ++g  G+++L
  EFC36892.1 210 LTNLTQLNLRITKLGANGVKSL 231
                 589****************997 PP

  == domain 6  score: 20.6 bits;  conditional E-value: 1.5e-07
       LRR_6   4 hLteLdLsgNdIgDeGa 20 
                 +LteLdLsgN+Ig eG+
  EFC36892.1 236 KLTELDLSGNQIGYEGV 252
                 8***************9 PP

  == domain 7  score: 17.3 bits;  conditional E-value: 1.7e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L++L+L  N I+++Gae L+
  EFC36892.1 260 NLKKLNLGNNRITGDGAERLC 280
                 8*****************998 PP

  == domain 8  score: 0.2 bits;  conditional E-value: 0.53
       LRR_6   4 hLteLdLs 11 
                 +LteLdL+
  EFC36892.1 284 NLTELDLR 291
                 7*****96 PP

  == domain 9  score: 9.0 bits;  conditional E-value: 0.0008
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt  +L  N+Ig  Gae L+
  EFC36892.1 299 KNLTQINLCLNQIGPNGAERLC 320
                 5899***************998 PP

  == domain 10  score: 8.6 bits;  conditional E-value: 0.0011
       LRR_6   3 thLteLdLsgNdIgD 17 
                 t+Lt L+L++N Ig 
  EFC36892.1 323 TNLTQLNLRSNLIGA 337
                 89***********95 PP

  == domain 11  score: 17.3 bits;  conditional E-value: 1.8e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt LdL +N I D+Ga+ L
  EFC36892.1 348 NLTQLDLGYNRIEDDGAQRL 367
                 8****************987 PP

  == domain 12  score: 19.3 bits;  conditional E-value: 4e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt LdLsgN+Ig  Ga++L+
  EFC36892.1 371 KKLTQLDLSGNQIGSIGAQSLS 392
                 58*****************996 PP

  == domain 13  score: 12.8 bits;  conditional E-value: 4.7e-05
       LRR_6   3 thLteLdLsgNdIgD 17 
                 t+Lt+LdL+gN+I D
  EFC36892.1 395 TNLTHLDLNGNGIED 409
                 89***********99 PP

  == domain 14  score: 18.4 bits;  conditional E-value: 7.5e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt L L++N IgD+Ga+ L+
  EFC36892.1 418 KKLTRLGLNDNRIGDDGAKYLS 439
                 58****************9885 PP

  == domain 15  score: 19.3 bits;  conditional E-value: 4e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L+L  N+IgD Gae+L+
  EFC36892.1 442 NKLTHLSLDNNGIGDTGAECLS 463
                 79******************96 PP

  == domain 16  score: 5.4 bits;  conditional E-value: 0.011
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 ++t+L+L +N+I  +G
  EFC36892.1 467 NITYLSLDDNEIETAG 482
                 79**********9988 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.0   2.8   1.9e-11   3.8e-08       2      61 .]     116     175 ..     115     175 .. 0.98
   2 !   32.4   6.6   2.9e-11   5.9e-08       1      61 []     187     247 ..     183     247 .. 0.98
   3 !   27.2   1.1   1.2e-09   2.3e-06      22      61 .]     256     295 ..     253     295 .. 0.94
   4 !   26.2   6.2   2.5e-09     5e-06       2      61 .]     300     359 ..     299     359 .. 0.95
   5 !   44.4   4.6   5.1e-15     1e-11       2      61 .]     348     407 ..     347     407 .. 0.98
   6 !   34.7   1.9   5.6e-12   1.1e-08       2      61 .]     419     478 ..     418     478 .. 0.98

  Alignments for each domain:
  == domain 1  score: 33.0 bits;  conditional E-value: 1.9e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt LdL++N+++    +  ++l+nLk L+L++N++    ++  s+L++L+ LdL +N +
  EFC36892.1 116 NLTQLDLCRNKIKPTVVKGLSSLTNLKKLNLGHNEIGNDGAKHVSSLTHLTALDLFDNGI 175
                 8********************************************************976 PP

  == domain 2  score: 32.4 bits;  conditional E-value: 2.9e-11
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nLt L+L nN + + + e  ++l+nL+ L+L+  +l     ++++gL++L++LdLsgN++
  EFC36892.1 187 TNLTQLNLGNNEIGDAGAEHISSLTNLTQLNLRITKLGANGVKSLRGLKKLTELDLSGNQI 247
                 59*********************************************************98 PP

  == domain 3  score: 27.2 bits;  conditional E-value: 1.2e-09
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + l+nLk L+L+nN++t   ++ + gL++L++LdL+  +L
  EFC36892.1 256 SELKNLKKLNLGNNRITGDGAERLCGLENLTELDLRAEHL 295
                 569********************************98876 PP

  == domain 4  score: 26.2 bits;  conditional E-value: 2.5e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt ++L+ N++   + e    l+nL+ L+L++Nl+  + ++++  L++L++LdL +Nr+
  EFC36892.1 300 NLTQINLCLNQIGPNGAERLCELTNLTQLNLRSNLIGAIKAESLCKLENLTQLDLGYNRI 359
                 8999999999999999999999************************************97 PP

  == domain 5  score: 44.4 bits;  conditional E-value: 5.1e-15
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt LdL  Nr+++ + +  ++l++L+ LdLs N++ ++ ++++s L++L++LdL+gN +
  EFC36892.1 348 NLTQLDLGYNRIEDDGAQRLSKLKKLTQLDLSGNQIGSIGAQSLSELTNLTHLDLNGNGI 407
                 9*********************************************************86 PP

  == domain 6  score: 34.7 bits;  conditional E-value: 5.6e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L L++Nr+ + + +  + l++L++L+L nN +    ++++s L+++++L L++N +
  EFC36892.1 419 KLTRLGLNDNRIGDDGAKYLSELNKLTHLSLDNNGIGDTGAECLSKLKNITYLSLDDNEI 478
                 79********************************************************87 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   2.0   2.2e-07   0.00043       2      36 ..     116     151 ..     113     157 .. 0.88
   2 !   23.2   0.9   3.4e-08   6.7e-05       1      38 [.     163     201 ..     163     208 .. 0.90
   3 !   19.8   4.1     4e-07    0.0008       1      39 [.     187     223 ..     187     227 .. 0.85
   4 !   18.7   2.0   8.5e-07    0.0017       1      36 [.     211     247 ..     211     259 .. 0.80
   5 !   19.5   7.1   4.7e-07   0.00094       1      41 [.     259     300 ..     259     316 .. 0.76
   6 !   10.2   5.0   0.00041      0.82       1      39 [.     299     338 ..     299     347 .. 0.81
   7 !   23.1   1.7   3.7e-08   7.3e-05       1      38 [.     323     361 ..     323     369 .. 0.88
   8 !   29.4   0.5   3.8e-10   7.6e-07       2      39 ..     348     386 ..     347     394 .. 0.87
   9 !   25.3   1.5   7.3e-09   1.5e-05       1      38 [.     395     432 ..     395     440 .. 0.87
  10 !   21.2   0.9   1.5e-07   0.00029       2      37 ..     443     479 ..     442     486 .. 0.89

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 2.2e-07
                 S--EEE--SS---.E-S-.HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqlt.dipl.leklpnLkeLdLsgNnli 36 
                 nL+ LdL  N+++ ++   l++l+nLk+L+L +N  i
  EFC36892.1 116 NLTQLDLCRNKIKpTVVKgLSSLTNLKKLNLGHN-EI 151
                 9************998889999*********666.55 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 3.4e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L+ LdL++N +   +   l++l+nL++L+L gNn i+d
  EFC36892.1 163 THLTALDLFDNGIGPNGAqrLSSLTNLTQLNL-GNNEIGD 201
                 68************877788889*********.9999987 PP

  == domain 3  score: 19.8 bits;  conditional E-value: 4e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +nL+ L+L+nN + d +   +++l+nL++L+L +   it+l
  EFC36892.1 187 TNLTQLNLGNNEIGDAGAehISSLTNLTQLNL-R---ITKL 223
                 7**************99986668*********.4...4444 PP

  == domain 4  score: 18.7 bits;  conditional E-value: 8.5e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +nL+ L+L+ ++l   +   l++l++L+eLdLsgN +i
  EFC36892.1 211 TNLTQLNLRITKLGANGVksLRGLKKLTELDLSGN-QI 247
                 79*******87777766688889************.77 PP

  == domain 5  score: 19.5 bits;  conditional E-value: 4.7e-07
                 SS--EEE--SS---.E-S-...HHH-TT--EEE-.-S-----GGG CS
       LRR_4   1 pnLevLdLsnNqlt.dipl...leklpnLkeLdLsgNnlitdlde 41 
                 +nL++L+L+nN++t d  +   l +l nL+eLdL +   +++l +
  EFC36892.1 259 KNLKKLNLGNNRITgD--GaerLCGLENLTELDL-RAEHLSQLKN 300
                 79************55..4346558********9.3323444433 PP

  == domain 6  score: 10.2 bits;  conditional E-value: 0.00041
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +nL+ ++L  Nq+   +   l  l+nL++L+L + nli+ +
  EFC36892.1 299 KNLTQINLCLNQIGPNGAerLCELTNLTQLNL-RSNLIGAI 338
                 69999999988***777766336*********.66699887 PP

  == domain 7  score: 23.1 bits;  conditional E-value: 3.7e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +nL+ L+L++N +  i    l kl nL++LdL g n+i+d
  EFC36892.1 323 TNLTQLNLRSNLIGAIKAesLCKLENLTQLDL-GYNRIED 361
                 7*****************76559*********.5558876 PP

  == domain 8  score: 29.4 bits;  conditional E-value: 3.8e-10
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 nL+ LdL+ N++ d +   l+kl++L++LdLsgN +i+++
  EFC36892.1 348 NLTQLDLGYNRIEDDGAqrLSKLKKLTQLDLSGN-QIGSI 386
                 9************855578889************.99998 PP

  == domain 9  score: 25.3 bits;  conditional E-value: 7.3e-09
                 SS--EEE--SS---.E-S-HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLsgNnlitd 38 
                 +nL++LdL++N +    + l+kl++L+ L L++N +i+d
  EFC36892.1 395 TNLTHLDLNGNGIEdGAQHLSKLKKLTRLGLNDN-RIGD 432
                 7*************55555999*********777.8865 PP

  == domain 10  score: 21.2 bits;  conditional E-value: 1.5e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L++L+L nN + d +   l+kl+n ++L+L +N  i+
  EFC36892.1 443 KLTHLSLDNNGIGDTGAecLSKLKNITYLSLDDN-EIE 479
                 7*************99999999*********777.554 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1      0.21   4.3e+02       1      12 [.     116     127 ..     116     138 .. 0.81
   2 !    8.2   0.2    0.0022       4.4       1      22 [.     140     161 ..     140     184 .. 0.82
   3 !    6.7   0.1    0.0072        14       1      23 []     188     210 ..     188     210 .. 0.89
   4 ?   -3.0   0.1         9   1.8e+04       1       8 [.     212     219 ..     212     225 .. 0.83
   5 !    8.0   0.1    0.0027       5.4       1      21 [.     236     256 ..     236     258 .. 0.80
   6 !    9.5   0.2   0.00083       1.6       1      22 [.     260     281 ..     260     282 .. 0.83
   7 ?    1.2   0.7      0.46   9.2e+02       1      15 [.     284     298 ..     284     319 .. 0.69
   8 ?    4.3   0.3     0.042        83       1      23 []     324     346 ..     324     346 .. 0.88
   9 ?    4.8   0.0     0.029        58       1      21 [.     348     368 ..     348     370 .. 0.80
  10 !    9.3   0.0   0.00099         2       1      23 []     372     394 ..     372     394 .. 0.91
  11 !    8.7   0.1    0.0015         3       1      20 [.     396     414 ..     396     417 .. 0.75
  12 ?    0.8   0.0      0.62   1.2e+03       1      21 [.     419     439 ..     419     441 .. 0.82
  13 !    9.0   0.1    0.0012       2.4       1      23 []     443     465 ..     443     465 .. 0.95
  14 ?    0.4   0.0      0.82   1.6e+03       1      22 [.     467     488 ..     467     492 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.21
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+ LdL++n +
  EFC36892.1 116 NLTQLDLCRNKI 127
                 89********87 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0022
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++L+L++n +++ ++ + ++
  EFC36892.1 140 NLKKLNLGHNEIGNDGAKHVSS 161
                 8**********96655555544 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0072
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ L+L+nn +++ +++++++L
  EFC36892.1 188 NLTQLNLGNNEIGDAGAEHISSL 210
                 89**********99999988876 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 9
       LRR_1   1 nLrhLdLs 8  
                 nL+ L+L+
  EFC36892.1 212 NLTQLNLR 219
                 79999994 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0027
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++LdLs+n+++  + n ++
  EFC36892.1 236 KLTELDLSGNQIGYEGVNNLS 256
                 79*********9777776665 PP

  == domain 6  score: 9.5 bits;  conditional E-value: 0.00083
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++L+L+nn+++g +++ +++
  EFC36892.1 260 NLKKLNLGNNRITGDGAERLCG 281
                 8***********9887766665 PP

  == domain 7  score: 1.2 bits;  conditional E-value: 0.46
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL++LdL+  +l++l
  EFC36892.1 284 NLTELDLRAEHLSQL 298
                 899999966665433 PP

  == domain 8  score: 4.3 bits;  conditional E-value: 0.042
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ L+L++n ++ + ++s+++L
  EFC36892.1 324 NLTQLNLRSNLIGAIKAESLCKL 346
                 89*********988888888876 PP

  == domain 9  score: 4.8 bits;  conditional E-value: 0.029
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL+ LdL++n++++ +++ ++
  EFC36892.1 348 NLTQLDLGYNRIEDDGAQRLS 368
                 89*********9877766555 PP

  == domain 10  score: 9.3 bits;  conditional E-value: 0.00099
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L+ LdLs+n++++++++s++ L
  EFC36892.1 372 KLTQLDLSGNQIGSIGAQSLSEL 394
                 7999************9999876 PP

  == domain 11  score: 8.7 bits;  conditional E-value: 0.0015
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL+hLdL++n ++  +++++
  EFC36892.1 396 NLTHLDLNGNGIE-DGAQHL 414
                 8*********994.555555 PP

  == domain 12  score: 0.8 bits;  conditional E-value: 0.62
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L L++n++++ ++ +++
  EFC36892.1 419 KLTRLGLNDNRIGDDGAKYLS 439
                 799********9888777766 PP

  == domain 13  score: 9.0 bits;  conditional E-value: 0.0012
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L+hL L nn +++ +++++++L
  EFC36892.1 443 KLTHLSLDNNGIGDTGAECLSKL 465
                 7******************9987 PP

  == domain 14  score: 0.4 bits;  conditional E-value: 0.82
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 n ++L L +n ++  ++ ++ +
  EFC36892.1 467 NITYLSLDDNEIETAGKKHLRK 488
                 6789******997777766665 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.6   0.00062       1.2      22     119 ..     118     217 ..      99     227 .. 0.55
   2 !   13.7   0.4   1.7e-05     0.034      45     107 ..     238     302 ..     232     312 .. 0.85
   3 !    8.7   2.1   0.00058       1.1      62     144 ..     294     378 ..     284     383 .. 0.60
   4 !   10.1   0.3   0.00021      0.41      56     125 ..     339     407 ..     321     415 .. 0.76
   5 !   26.2   0.1   2.4e-09   4.7e-06      24     143 ..     376     498 ..     375     505 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00062
       LRR_9  22 reldlrgyki.p.vienlGatldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkle 116
                  +ldl  +ki p v++ l ++l  +  ++l  n+i +     +  l  l +l l +n i   + +   +l nl++l l nne+ + +  + + sl +l+
  EFC36892.1 118 TQLDLCRNKIkPtVVKGL-SSLTNLKKLNLGHNEIGNdgAKHVSSLTHLTALDLFDNGIGPNGAQRLSSLTNLTQLNLGNNEIGDAGA-EHISSLTNLT 214
                 445555555422122222.455556666666666654113344555556666666666666666666666666666666666666555.5555555555 PP

       LRR_9 117 lls 119
                  l 
  EFC36892.1 215 QLN 217
                 554 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1.7e-05
       LRR_9  45 dtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladld 107
                   +dls n+i    ++++  lk lk l l nnri+  + +    l nl+el l  ++l +l +l 
  EFC36892.1 238 TELDLSGNQIgyEGVNNLSELKNLKKLNLGNNRITGDGAERLCGLENLTELDLRAEHLSQLKNLT 302
                 568999999954579*******************988887778899*****99999999998875 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00058
       LRR_9  62 llkrlktlllnnnrivriaegleev...lPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrl 144
                 +l +lk l   n  + +i+++ +e    l nl++l l +n +  +   + l +l++l+ l l  n + +    rl  + kl ql l
  EFC36892.1 294 HLSQLKNLTQINLCLNQIGPNGAERlceLTNLTQLNLRSNLIGAIKA-ESLCKLENLTQLDLGYNRIEDDGAQRLSKLKKLTQLDL 378
                 45555555555555555555555541114455666677777777665.77777777777777777777777777776666666654 PP

  == domain 4  score: 10.1 bits;  conditional E-value: 0.00021
       LRR_9  56 kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 k +++  l+ l  l l  nri   + +    l +l++l l++n++ +++  + l +l +l+ l l  n +
  EFC36892.1 339 KAESLCKLENLTQLDLGYNRIEDDGAQRLSKLKKLTQLDLSGNQIGSIGA-QSLSELTNLTHLDLNGNGI 407
                 55677778888888888888888888877888888888899999988887.8888888888888777765 PP

  == domain 5  score: 26.2 bits;  conditional E-value: 2.4e-09
       LRR_9  24 ldlrgykipvienlG.atldqfdtidlsdndirk.ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsl 120
                 ldl g++i  i     + l  +  +dl+ n i +  + +  lk+l  l ln+nri   + +    l +l++l l nn + + +  + l +lk++++lsl
  EFC36892.1 376 LDLSGNQIGSIGAQSlSELTNLTHLDLNGNGIEDgAQHLSKLKKLTRLGLNDNRIGDDGAKYLSELNKLTHLSLDNNGIGDTGA-ECLSKLKNITYLSL 473
                 66777776666544413467788899*****986356788899999999********99999999****************998.************** PP

       LRR_9 121 lknpvtn..kkeyrlyviyklkqlr 143
                  +n + +  kk+ r+ +   l ++r
  EFC36892.1 474 DDNEIETagKKHLRKLIRCGLCSIR 498
                 ***9854337888887766666555 PP

>> LRR_5  BspA type Leucine rich repeat region (6 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.014        27      25     113 ..     127     220 ..     104     235 .. 0.65
   2 !    7.3   0.0    0.0022       4.3      31     112 ..     184     269 ..     149     283 .. 0.75
   3 !   18.2   0.0   9.4e-07    0.0019      11     107 ..     323     420 ..     310     433 .. 0.80
   4 !   17.7   0.0   1.3e-06    0.0026      12     112 ..     372     476 ..     363     489 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.014
       LRR_5  25 IgeyaFsnctslksit.lpsslteigsyaFsncssltsiti....pssltsigeyaFsncsslkeitlpsn.lttigssaFsnc.slesitipssv 113
                 I+  + ++ +sl++++ l+ + +eig+   ++ sslt++t      + +   g +  s+ ++l++++l +n + + g + +s+  +l+++++   +
  EFC36892.1 127 IKPTVVKGLSSLTNLKkLNLGHNEIGNDGAKHVSSLTHLTAldlfDNGIGPNGAQRLSSLTNLTQLNLGNNeIGDAGAEHISSLtNLTQLNLR--I 220
                 555555666666666424446667776666666666666653333556777777788888888888886654667777777664477776663..4 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0022
       LRR_5  31 snctslksitlpss.lteigsyaFsncssltsitips.sltsigeyaFsncsslkeitlpsn.lttigssaFsnc.slesitipss 112
                 s+ t+l++++l ++ +   g +  s+ ++lt++++   +l   g ++ ++ ++l+e++l+ n + + g +  s+  +l+++++ ++
  EFC36892.1 184 SSLTNLTQLNLGNNeIGDAGAEHISSLTNLTQLNLRItKLGANGVKSLRGLKKLTELDLSGNqIGYEGVNNLSELkNLKKLNLGNN 269
                 45667777777654477777777777777777777633677777778888888888888764477777777777667777777654 PP

  == domain 3  score: 18.2 bits;  conditional E-value: 9.4e-07
       LRR_5  11 cnltsitipssvt.sIgeyaFsnctslksitlpss.lteigsyaFsncssltsitips.sltsigeyaFsncsslkeitlpsnlttigssaFsncsles 106
                 +nlt++++ s+++  I+ ++ ++ ++l++++l  + ++  g +  s+ ++lt+++++  ++ sig ++ s+ ++l++++l+ n   i++ a   ++l++
  EFC36892.1 323 TNLTQLNLRSNLIgAIKAESLCKLENLTQLDLGYNrIEDDGAQRLSKLKKLTQLDLSGnQIGSIGAQSLSELTNLTHLDLNGN--GIEDGAQHLSKLKK 419
                 599999999986538****************966449999********9*******8549*****************999665..45555544444444 PP

       LRR_5 107 i 107
                 +
  EFC36892.1 420 L 420
                 4 PP

  == domain 4  score: 17.7 bits;  conditional E-value: 1.3e-06
       LRR_5  12 nltsitip.ssvtsIgeyaFsnctslksitlpsslteigsyaFsncssltsitips.sltsigeyaFsncsslkeitlpsn.lttigssaFsnc.sles 106
                 +lt+++++ +++ sIg ++ s+ t+l++++l+ +  e g +  s+ ++lt + +++  +   g +  s+ ++l++++l +n + + g ++ s+  +++ 
  EFC36892.1 372 KLTQLDLSgNQIGSIGAQSLSELTNLTHLDLNGNGIEDGAQHLSKLKKLTRLGLNDnRIGDDGAKYLSELNKLTHLSLDNNgIGDTGAECLSKLkNITY 470
                 8999999967899*****************************************985799999***************887699999999999889999 PP

       LRR_5 107 itipss 112
                 + + ++
  EFC36892.1 471 LSLDDN 476
                 988764 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.2   0.0   1.7e-11   3.4e-08       1      35 [.      27      62 ..      27      67 .. 0.87

  Alignments for each domain:
  == domain 1  score: 33.2 bits;  conditional E-value: 1.7e-11
  F-box-like  1 isrLPdEiLlqIFsyLpps.dLlrlalVCrrWrrva 35
                i++LPdE Ll+IFs+L+++   +++a VC+ W++v+
  EFC36892.1 27 INSLPDENLLDIFSFLSTKeHFSQCAYVCSNWNQVT 62
                679*************88836777**********97 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   3.3e-08   6.7e-05       3      39 ..      27      64 ..      26      72 .. 0.92

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 3.3e-08
                HHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTT CS
       F-box  3 lsrLPsevlrhILerLplsd.llalrrVSkgwrilids 39
                + +LP+e l++I+++L++++    ++ V+ +w++++++
  EFC36892.1 27 INSLPDENLLDIFSFLSTKEhFSQCAYVCSNWNQVTRG 64
                578*******************************9887 PP

>> Peripla_BP_7  Periplasmic binding protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.1     0.009        18      29      59 ..     142     172 ..     136     175 .. 0.94
   2 ?    2.8   0.1     0.067   1.3e+02      29      56 ..     262     289 ..     254     291 .. 0.86
   3 ?    0.3   0.1      0.38   7.6e+02      30      56 ..     351     377 ..     324     379 .. 0.73
   4 ?   -0.3   0.1      0.61   1.2e+03      31      56 ..     423     448 ..     412     455 .. 0.82
   5 ?   -1.6   0.1       1.5     3e+03      39      53 ..     452     466 ..     426     470 .. 0.50

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.009
                   HHTTEEEEEEE-BSS-THHHHTTS--GGG-S CS
  Peripla_BP_7  29 dllnldlevvaGDgqsEssildrlgnlkkyD 59 
                   ++lnl  ++++ Dg +  s l +l+ l+ +D
    EFC36892.1 142 KKLNLGHNEIGNDGAKHVSSLTHLTALDLFD 172
                   689**************************99 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.067
                   HHTTEEEEEEE-BSS-THHHHTTS--GG CS
  Peripla_BP_7  29 dllnldlevvaGDgqsEssildrlgnlk 56 
                   ++lnl  + + GDg +    l+ l++l+
    EFC36892.1 262 KKLNLGNNRITGDGAERLCGLENLTELD 289
                   689***********99998888888775 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.38
                   HTTEEEEEEE-BSS-THHHHTTS--GG CS
  Peripla_BP_7  30 llnldlevvaGDgqsEssildrlgnlk 56 
                    l+l  + ++ Dg +  s l +l++l+
    EFC36892.1 351 QLDLGYNRIEDDGAQRLSKLKKLTQLD 377
                   355566889*********999999875 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.61
                   TTEEEEEEE-BSS-THHHHTTS--GG CS
  Peripla_BP_7  31 lnldlevvaGDgqsEssildrlgnlk 56 
                   l l+ + ++ Dg +  s l++l+ l+
    EFC36892.1 423 LGLNDNRIGDDGAKYLSELNKLTHLS 448
                   6677789999************9875 PP

  == domain 5  score: -1.6 bits;  conditional E-value: 1.5
                   E-BSS-THHHHTTS- CS
  Peripla_BP_7  39 aGDgqsEssildrlg 53 
                   +G g++ +++l +l 
    EFC36892.1 452 NGIGDTGAECLSKLK 466
                   344555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (548 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       341  (0.0190195); expected 358.6 (0.02)
Passed bias filter:                      263  (0.014669); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.72u 0.29s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 3202.71
//
Query:       EFC36893.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       830  (0.0462937); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 1907.31
//
Query:       EFC36894.1  [L=292]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (292 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       610  (0.0340231); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1798.43
//
Query:       EFC36895.1  [L=921]
Description: hypothetical protein NAEGRDRAFT_75398 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.1e-37  125.8   7.9    1.2e-36  125.5   0.9    3.6  4  Telomere_reg-2  Telomere length regulation protein
  ------ inclusion threshold ------
       0.26   10.8   4.7       0.18   11.4   0.1    2.9  3  DUF3452         Domain of unknown function (DUF3452)


Domain annotation for each model (and alignments):
>> Telomere_reg-2  Telomere length regulation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.38   3.4e+03      39      77 ..     279     319 ..     227     331 .. 0.58
   2 ?   -3.0   0.0       1.1     1e+04       3      32 ..     413     444 ..     411     455 .. 0.64
   3 !  125.5   0.9   1.3e-40   1.2e-36       1     109 []     579     711 ..     579     711 .. 0.99
   4 ?    2.5   0.1     0.022   1.9e+02      37      88 ..     832     881 ..     824     889 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.38
  Telomere_reg-2  39 eenaveLataLltledk..fdienfeelrlnalvallvatp 77 
                     +e   +L ++L +le++  f+i+  e+   + ++++l ++p
      EFC36895.1 279 SESNHQLYRVLSSLENRkgFNISALENIVKSFIIKVLKSRP 319
                     45556777777777665224666666666666666666665 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.1
  Telomere_reg-2   3 YlkdllelLr..dkddyekieaaLksaeeLir 32 
                     Y++ +l++L    +++ + i  +Lk++ e i+
      EFC36895.1 413 YVSYCLAMLIslMSKEEFEISNTLKNCIEGIQ 444
                     77778888876634444666667776655555 PP

  == domain 3  score: 125.5 bits;  conditional E-value: 1.3e-40
  Telomere_reg-2   1 pvYlkdllelLr....dkddyekieaaLksaeeLirrkadevee.naveLataLltledkfdienfeelrlnalvallvatpekvae........ 82 
                     p+Y+kd++++L+    dkd+++kieaaLk+a+++i+r++++v++ n+v+L+taLlt++++ +i+n++++r+na+vall++t+++v+e        
      EFC36895.1 579 PYYIKDVIDFLFandqDKDQMFKIEAALKYATTIIERADPKVVQlNGVNLCTALLTCSET-TIDNYFTDRMNAMVALLTKTCSSVIElqfdkqdq 672
                     8**************999*****************************************9.9********************************* PP

  Telomere_reg-2  83 ............ylteeffsnqyslqqRidiLsvlalaA 109
                                 ylt++f+snq++++qRidiL+vl+++A
      EFC36895.1 673 rsidfedetvliYLTNKFWSNQVTQAQRIDILTVLVKSA 711
                     *************************************99 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.022
  Telomere_reg-2  37 eveenaveLataLltledkfdienfeelrlnalvallvatpekvaeylteef 88 
                     e++ n  e++ +L+ l+ k d++++++lr + l  l ++ ++ + e+l +e+
      EFC36895.1 832 ELARNTIEFCWTLI-LHCK-DVQKVNSLRASILNTLHTSFCSCTSETLLNEV 881
                     66777777776654.3344.679**********************9999986 PP

>> DUF3452  Domain of unknown function (DUF3452)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1      0.16   1.5e+03      63      88 ..     482     525 ..     475     562 .. 0.42
   2 ?   -1.4   0.1      0.17   1.5e+03       4      32 ..     621     651 ..     619     742 .. 0.71
   3 ?   11.4   0.1     2e-05      0.18      96     130 ..     835     871 ..     825     874 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.16
     DUF3452  63 YrqiFee..................lFlspadkeskrskknsaa 88 
                 Y++  +e                  +F +p+++ +k+ +k++++
  EFC36895.1 482 YKDCLDEltsniqnsstnfserkpnVFGEPKSNLKKDLDKKKKE 525
                 44444443333333333333333334444442222222222222 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.17
     DUF3452   4 vegncvsLt.rLLrscklsikqFf.kklkkw 32 
                 v+ n+v+L+  LL + ++ i ++f ++++ +
  EFC36895.1 621 VQLNGVNLCtALLTCSETTIDNYFtDRMNAM 651
                 5667788862577777788877551456555 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 2e-05
     DUF3452  96 sklfefgWlLFlllkn.elps.sskdlvtslnlllcc 130
                  ++ ef+W+L l++k+ ++ +   + + ++l+   c 
  EFC36895.1 835 RNTIEFCWTLILHCKDvQKVNsLRASILNTLHTSFCS 871
                 5688************955554999999999988885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (921 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1209  (0.0674327); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.80u 0.27s 00:00:01.07 Elapsed: 00:00:00.48
# Mc/sec: 5740.24
//
Query:       EFC36896.1  [L=640]
Description: folylpolyglutamate synthetase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-10   41.8   0.2    1.1e-09   38.6   0.0    2.5  2  Mur_ligase_M  Mur ligase middle domain
  ------ inclusion threshold ------
        2.5    7.9   5.0        2.1    8.2   0.0    2.9  3  DSPc          Dual specificity phosphatase, catalytic domain


Domain annotation for each model (and alignments):
>> Mur_ligase_M  Mur ligase middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       0.7   6.3e+03      15      45 ..      73     103 ..      66     120 .. 0.63
   2 !   38.6   0.0   1.2e-13   1.1e-09       1     191 [.     138     355 ..     138     356 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.7
                   HHHHHCTEEEEETTCSS-THHHHHHHHHHHH CS
  Mur_ligase_M  15 aailekagkvigtvgttnneiglpktlaeme 45 
                    ++ e a + + t ++++n++++  +l + +
    EFC36896.1  73 TQLSEMASQEHITEKNYENALKILDSLISRK 103
                   4555555666777777777777776665554 PP

  == domain 2  score: 38.6 bits;  conditional E-value: 1.2e-13
                   EESSS-HHHHHHHHHHHHHCTEEEEETTC..............................................SS-THHHHHHHHHHHHHTT-SE CS
  Mur_ligase_M   1 vTGtnGKTTtteliaailekagkvigtvg..............................................ttnneiglpktlaemekkeaey 51 
                   v+Gt+GK +t  +++ il+k+g ++g+                                                tt   + +  +l+ + ++++++
    EFC36896.1 138 VAGTKGKGSTCAFCEYILKKQGLKTGLFTsphlvdireriridgglvsketftnafwycydrltqettseqtfpmTTYFRLMVLVSLKAFIDEKVDV 234
                   89*******************77777776777*******************************************99999999999999999***** PP

                   EEEE--HCHHHCTTTCCHCBESEEEE---TSTTHHHH.SSHHHHHHHHHHHHHTSETTCEEEEETTSC...CHHHHHCTCCTCEEEEESSSTSECEE CS
  Mur_ligase_M  52 avlEvsshglgekrlegllkpdvavitnispdHldfh.gtlenyaeaKaelferlkeegiavinaddpyakelikklkkakvkvvtfglekeaedlr 147
                   a++Ev+    g+    ++++p v  i +i+ dH+d + +t+ ++ + Ka ++++  +  +  +   +++++            +++ +++++a  ++
    EFC36896.1 235 AIIEVGIG--GKYDATNIIDPVVCGISSIGYDHMDLLgETITEISAQKAGIMKKDVP--CITCPQKEEALAS-----------FIKTSEQTHAPLYM 316
                   ********..88888889*****************9879*************85443..4555544553444...........55555555553333 PP

                   EEEEEEETTEEEEEEEEETTEEEEEEESSCSCHHHHHHHHHHHH CS
  Mur_ligase_M 148 aknieeksegteiellevkggeleieipllGkhnvyNalaaiaa 191
                     +ie ++    i  l+ kg   ++ei+l G+h+  Na++aia+
    EFC36896.1 317 CPSIEDYER---I--LNEKGSINKLEIGLKGEHQRWNAALAIAL 355
                   334444222...2..32344555699999******9*9999997 PP

>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.6      0.16   1.4e+03      14     101 ..      67     160 ..      50     167 .. 0.45
   2 ?   -0.2   0.0     0.087   7.8e+02      35      83 ..     478     526 ..     467     528 .. 0.67
   3 ?    8.2   0.0   0.00023       2.1      32      79 ..     560     617 ..     532     620 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.16
                 HHHHTCSEEEEESSSSSECECCTTTTSEEEEECCES.........STTSCCGGGHHHHHHHHHHH...HHTT-EEEEEESSSSSHHHHHHHHHHHHHHT CS
        DSPc  14 lsklgitlvinvtkevpnanalkkseieklripved.........ehetkiskyleeavefidka...kqkgkkvlVHCqaGisRSatliiaYlmktkn 100
                 ++++ it   +++++ +      ++++++  +++ d         ++ +  +  le ++++ dk+   ++k + + V  + G   S +  + Y++k+++
  EFC36896.1  67 NQQNTITQLSEMASQEHI-----TEKNYENALKILDslisrkappHDANAHELSLEITKSYCDKIgldHSKLQMIHVAGTKGKG-STCAFCEYILKKQG 159
                 333333333333322211.....1222222222222333334443333333444444444444444335555555555555554.55666666666666 PP

                 S CS
        DSPc 101 l 101
                 l
  EFC36896.1 160 L 160
                 5 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.087
                 CTTTTSEEEEECCESSTTSCCGGGHHHHHHHHH.HHHHTT-EEEEEESSS CS
        DSPc  35 lkkseieklripvedehetkiskyleeavefid.kakqkgkkvlVHCqaG 83 
                 ++ +e+e++++  +d +e++ s  +++ ++  + +  +++kkvlV    G
  EFC36896.1 478 QAPQEFEDISYISSD-NEENSSLTFQRRIDAQNsESSKDHKKVLVFNYTG 526
                 455666666666666.5666666666666665537799999999986666 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00023
                 C.........ECCTTTTSEEEEEC.CESSTTSCCGGGHHHHHHHHHHHHHTT-EEEEE CS
        DSPc  32 a.........nalkkseieklrip.vedehetkiskyleeavefidkakqkgkkvlVH 79 
                              k ++ +kl+i    de++  i + ++++ +f+ ++k+++ +vlV 
  EFC36896.1 560 VnkstgmskaESEKLNNLKKLWIElTGDESKVSIFNSINQVLDFVWDMKSQQVSVLVT 617
                 03333433336668889999999988889***************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (640 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1026  (0.0572257); expected 358.6 (0.02)
Passed bias filter:                      578  (0.0322383); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.24s 00:00:00.75 Elapsed: 00:00:00.39
# Mc/sec: 4863.40
//
Query:       EFC36897.1  [L=852]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   1.2e-262  873.5   9.4   1.5e-262  873.3   9.4    1.0  1  V_ATPase_I     V-type ATPase 116kDa subunit family
  ------ inclusion threshold ------
      0.081   13.2   0.2        2.2    8.5   0.0    2.5  2  EIIA-man       PTS system fructose IIA component
       0.12   12.4   0.1        8.7    6.4   0.0    2.6  2  Baculo_PEP_C   Baculovirus polyhedron envelope protein, PEP, 
       0.23   11.6   3.5        2.2    8.5   0.1    3.0  3  Fib_alpha      Fibrinogen alpha/beta chain family
       0.48   10.8   4.4          8    6.9   0.1    3.3  3  CLZ            C-terminal leucine zipper domain of cyclic nuc
       0.56   10.6   3.9        2.1    8.7   1.2    2.9  2  Tup_N          Tup N-terminal
        1.5    9.1   9.9       0.43   10.8   1.8    3.1  3  TMF_TATA_bd    TATA element modulatory factor 1 TATA binding
          4    7.5   8.5        2.6    8.1   2.2    2.7  2  TPR_MLP1_2     TPR/MLP1/MLP2-like protein


Domain annotation for each model (and alignments):
>> V_ATPase_I  V-type ATPase 116kDa subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  873.3   9.4  6.5e-266  1.5e-262       2     813 .]      54     845 ..      53     845 .. 0.89

  Alignments for each domain:
  == domain 1  score: 873.3 bits;  conditional E-value: 6.5e-266
  V_ATPase_I   2 eLGelglvqfrDlnedvnafqrkfvkevrrcdemerklrfleeeieklekavikeeea....eesleapeekeldeleeelekleeelkelnenleklk 96 
                 +LG+lglv+f+Dl++++n fqr++++ev+rc+++er +rf+e+e+ek + + ++e+++    +++l++ + + ld++e+e+ kle+el++l++  e+l 
  EFC36897.1  54 RLGQLGLVEFKDLSSHLNGFQRHYANEVKRCEDLERIIRFFEQEMEKSNVKFVEESDKmngdVNELQEGSVNLLDRYEREFVKLEAELRNLSDGIEQLV 152
                 79*********************************************88888877777888889999999999************************** PP

  V_ATPase_I  97 kelnelvelkavlekakefleeeeeeeeeeeseeeeeekeeeeeeeseeeeeeelleeeeelsfvaGvikrekveaferilwralrgnlflrqaeieep 195
                 +++++++e  +v+e a ++  e++ee+++              ++++  ++e+    + ++l+ ++Gvi++ekv+af+ +++r +rgn++ +  ei++p
  EFC36897.1 153 SQKSKAEEFLQVIELAGNLDGEASEESQS------------GASSSML-NRES----QMSSLGCLTGVIPSEKVSAFNMLIYRSTRGNAIPKLYEISSP 234
                 *************9999887643221111............1111111.1122....223589************************************ PP

  V_ATPase_I 196 ledpetgekveksvfiiffqgeqlkekikkicesfgaklyelpeseeereeklkeveeriedlekvleqteealkevleeiakeleewklkvkkekaiy 294
                 ++d++ g++v+k vf +ff +++ kekikkice++ga++y++p++e+   e+ k+v++++++le ++e+++++l ++l+eia++++ew+ +v +ekaiy
  EFC36897.1 235 IYDSKLGKTVSKLVFTVFFGSSTAKEKIKKICEAMGATIYDIPSDET-PGESSKKVNQQVRELEMTIENSKSRLLDLLSEIASNMSEWNNNVFREKAIY 332
                 *******************************************9776.677889********************************************* PP

  V_ATPase_I 295 htLnlfnldvtkkvliaegWvpkeeleeiqkalkeateessssvpsilneietketpPTyfrtnkfteafQeivdaYGiarYrEvNpalftiitFPFlF 393
                 htLn+fn+d  ++ ++a gWv+++++e++++ +++a+ e++ ++p+++++i+t+etpPT+f+tnkfte+fQ+iv++YGi++Y+E+Npa++++i FPFlF
  EFC36897.1 333 HTLNMFNYDI-RNSVVALGWVAERHVETVRREMEQAMFEMHVEIPTLVDIIHTDETPPTFFETNKFTEVFQQIVNSYGIPNYKEMNPAVASVIFFPFLF 430
                 ********99.77889*********************************************************************************** PP

  V_ATPase_I 394 avMFGDiGHGlllllfalllvlkekklkkk.kkdeilemlfsgRYiillmGlfsiYtGliYNdifskslnlfgSswevkekaveeeelkkekkeekvYp 491
                 +vMFGD+GHGlll +f+++++++e++lk   +++e+l+m+f+gRYi++lmGlfsiYtG++YNd f++s++lf ++++++++ +       +k+e+++Yp
  EFC36897.1 431 SVMFGDFGHGLLLSIFSFCMIIFERRLKPIaENNELLAMIFQGRYILILMGLFSIYTGFLYNDGFGLSVDLFPTAFNFDQNGI------GHKDESRTYP 523
                 ****************************99899*********************************************54444......5778899*** PP

  V_ATPase_I 492 fGlDpaWklaenellflnSlKmKlsvilGviqMlfgvllslvNalyfkkkldiilefiPqllfllsifgYlvlliiyKWlvdwea...ekekapsllnt 587
                 fG+Dp W +++n+llf+nSlKmK+++i+Gv +M+ g+l+slvN+++f + ldi+lefiP+ll l+++fgY++++i+yKW+v+w +    + + p+ll t
  EFC36897.1 524 FGIDPGWFHTSNKLLFYNSLKMKMAIIFGVGHMTAGLLFSLVNMIQFGHFLDIFLEFIPELLILWCTFGYMSIMIVYKWCVNWGDethVNIEIPQLLPT 622
                 ***********************************************************************************9645534458****** PP

  V_ATPase_I 588 linmflskgkvkeeelye..........gqetvqvvLlllalvcvpvlllvkPlilklkhkkkkkkkekkkeeeeeeeeeeeeeeeeeeeeaeeeeeee 676
                 + ++fls+ k ++ +l+           +q++ q +Lll+a+++vp+ll++kP+i ++k+k+k kk  +++              +++e          
  EFC36897.1 623 MTDFFLSPWKMSQPPLFYfggsveeaqkKQTYAQLTLLLIAVISVPILLIPKPVIEYYKQKRKLKKVLESEP-----------VLSNSE---------- 700
                 ***********554544434444444448********************************98777643321...........111111.......... PP

  V_ATPase_I 677 eeeeeeeeeeeeeeeeeeefdfgevfihqvIhtIEfvLgciSnTASYLRLWALSLAHaqLseVlwemvlkkal........lksksvlgvillvilfav 767
                 ee++e + +e++ +++ e + f+e+fi+q+IhtIE+vL+++SnTASYLRLWALSLAHaqLseV+w+m+l   l        l+   v   i +++l+a+
  EFC36897.1 701 EESHEIKLDETKVTNHAEIEPFSELFIKQLIHTIEYVLNTVSNTASYLRLWALSLAHAQLSEVFWQMTLGILLnslesyplLEDILVHYGIGVFFLCAL 799
                 111222233344556678899*************************************************97755555543333333345999****** PP

  V_ATPase_I 768 favltvavLllmeglsafLHaLRLhWVEfqsKFykgdGykFepfsf 813
                 ++ +t++vLl+me+lsafLHa+RL W+Efq KF+ g+G  F+pfsf
  EFC36897.1 800 WFGMTIGVLLIMESLSAFLHAIRLTWIEFQGKFFGGTGSLFQPFSF 845
                 *********************************************9 PP

>> EIIA-man  PTS system fructose IIA component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.13   2.8e+02      28      54 ..     270     296 ..     255     314 .. 0.79
   2 ?    8.5   0.0     0.001       2.2      13      67 ..     330     382 ..     328     384 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.13
                 CEEEEEC-TTS-CCCHHHHHHHHHCTS CS
    EIIA-man  28 kviavggtpdesigtlaekikeaieev 54 
                   ++++++ de++g++++k++++++e+
  EFC36897.1 270 GATIYDIPSDETPGESSKKVNQQVREL 296
                 457999*****************9776 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.001
                 HHHHHHHCCHSSS-SCEEEEEC-TTS-CCCHHHHHHHHHCTS--TTEEEEEESSC CS
    EIIA-man  13 glaelleelagedqekviavggtpdesigtlaekikeaieevdsedevlvLvDlg 67 
                 +++++l+++  + +++v a+g + +  ++t+++++++a+ e+    e+ +LvD++
  EFC36897.1 330 AIYHTLNMFNYDIRNSVVALGWVAERHVETVRREMEQAMFEM--HVEIPTLVDII 382
                 799*********99*************************555..79999999996 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0039       8.7      47     113 ..      87     153 ..      55     160 .. 0.82
   2 ?    3.1   0.0      0.04        91      29      85 ..     290     344 ..     280     365 .. 0.59

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0039
  Baculo_PEP_C  47 LnalsedlksllaeldtrldtlltnLtdalnalqdtlrneLtnlnsiltnLlssvtNinstLnnllq 113
                   L+ +   +++ +++ + ++ + +++++  +n+lq+   n L+  + +   L +++ N+   ++ l++
    EFC36897.1  87 LERIIRFFEQEMEKSNVKFVEESDKMNGDVNELQEGSVNLLDRYEREFVKLEAELRNLSDGIEQLVS 153
                   44455555555555666999****************************************9999986 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.04
  Baculo_PEP_C  29 nvqilaqlatlldaietqLnalsedlksllaeldtrldtlltnLtdalnalqdtlrn 85 
                   n q+  +l+ ++++ +++L +l +++ s ++e ++++    +++ ++ln ++ ++rn
    EFC36897.1 290 NQQV-RELEMTIENSKSRLLDLLSEIASNMSEWNNNVFR-EKAIYHTLNMFNYDIRN 344
                   3344.4455555555555555555555555554444332.33445555555555555 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.57   1.3e+03      58     109 ..      70     121 ..      62     145 .. 0.58
   2 ?    2.2   0.1     0.082   1.8e+02      25      88 ..     126     190 ..     123     196 .. 0.73
   3 ?    8.5   0.1   0.00096       2.2      50     116 ..     254     319 ..     237     323 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.57
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHH CS
   Fib_alpha  58 vkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqn 109
                  +  +  ++++ k  +d +++i+ +++e+e+  +++ e+ d+    +++Lq+
  EFC36897.1  70 LNGFQRHYANEVKRCEDLERIIRFFEQEMEKSNVKFVEESDKMNGDVNELQE 121
                 4445555555666666666666666666666666666666666666666663 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.082
                 CCCCCCCCC...CHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  25 lllkyekdv...kkdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnvikksskelee 88 
                 ll++ye+++   + +l++l + +e++ +++++aee  + i+   + + + ++  ++    ss++l++
  EFC36897.1 126 LLDRYEREFvklEAELRNLSDGIEQLVSQKSKAEEFLQVIELAGNLDGEASE--ESQSGASSSMLNR 190
                 5777777652226799999999*************99999866555555554..6777788888874 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00096
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHH CS
   Fib_alpha  50 stkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesneq 116
                  +++a+e +k+i + + ++    + +d++  +ssk++++++ +l+ ti +  s++  L + + sn +
  EFC36897.1 254 GSSTAKEKIKKICEAMGATIYDIP-SDETPGESSKKVNQQVRELEMTIENSKSRLLDLLSEIASNMS 319
                 57899999******9999999999.7**************************888887777777655 PP

>> CLZ  C-terminal leucine zipper domain of cyclic nucleotide-gated channels
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.6     0.036        81      27      68 ..     103     144 ..      83     162 .. 0.80
   2 ?    6.9   0.1    0.0036         8      23      57 ..     283     317 ..     276     323 .. 0.88
   3 ?   -3.0   0.0       4.5     1e+04       4      15 ..     472     483 ..     470     484 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.036
         CLZ  27 keleekverLessLeaLqtrlarLlaeyessqrkLkqRitkL 68 
                  ++ e  +++++ ++ Lq     Ll+ ye    kL++ + +L
  EFC36897.1 103 VKFVEESDKMNGDVNELQEGSVNLLDRYEREFVKLEAELRNL 144
                 445566788899999999999999999998888888877776 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0036
         CLZ  23 gaeqkeleekverLessLeaLqtrlarLlaeyess 57 
                 g+  k+++++v++Le ++e+ + rl  Ll+e  s 
  EFC36897.1 283 GESSKKVNQQVRELEMTIENSKSRLLDLLSEIASN 317
                 57889**************************9875 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 4.5
         CLZ   4 kGreILlKdglL 15 
                  Gr IL+ +gl+
  EFC36897.1 472 QGRYILILMGLF 483
                 59*******996 PP

>> Tup_N  Tup N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   1.2   0.00093       2.1      27      75 ..      95     143 ..      78     145 .. 0.91
   2 ?    0.7   0.0      0.31   6.8e+02      31      43 ..     286     298 ..     278     314 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00093
       Tup_N  27 kdeyelkiqsqiqElqqirqtlyeLeeahrkikqqYEeeiarLkaeLes 75 
                 ++e+e++  + ++E +++   + eL+e   ++ ++YE+e  +L aeL +
  EFC36897.1  95 EQEMEKSNVKFVEESDKMNGDVNELQEGSVNLLDRYEREFVKLEAELRN 143
                 68999999999***********************************986 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.31
       Tup_N  31 elkiqsqiqElqq 43 
                  +k+++q++El++
  EFC36897.1 286 SKKVNQQVRELEM 298
                 5678888888875 PP

>> TMF_TATA_bd  TATA element modulatory factor 1 TATA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1         1   2.3e+03      14      51 ..      84     104 ..      74     122 .. 0.46
   2 ?   10.8   1.8   0.00019      0.43       8      69 ..     121     181 ..     115     197 .. 0.77
   3 ?    2.0   0.2      0.11   2.4e+02      57      98 ..     284     322 ..     256     335 .. 0.59

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1
  TMF_TATA_bd  14 verlsseirrlEgElaslkeelerleaerdeareeivk 51 
                   e l+  ir  E E++++                  vk
   EFC36897.1  84 CEDLERIIRFFEQEMEKS-----------------NVK 104
                  444444444444444433.................333 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00019
  TMF_TATA_bd   8 gpsvqlverlsseirrlEgElaslkeelerleaerdeareeivklmkeneelkelkkeleel 69 
                  + sv+l++r + e  +lE+El++l + +e+l +++++a+ e +++++   +l+ +++e ++ 
   EFC36897.1 121 EGSVNLLDRYEREFVKLEAELRNLSDGIEQLVSQKSKAE-EFLQVIELAGNLDGEASEESQS 181
                  56899******************************9986.6777776666666655555544 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.11
  TMF_TATA_bd  57 eelkelkkeleelekeleelqeryetlLellGeksEeveELr 98 
                  e+ k+ +++++ele  +e+ ++r   lL ll e + ++ E  
   EFC36897.1 284 ESSKKVNQQVRELEMTIENSKSR---LLDLLSEIASNMSEWN 322
                  45555555555565555555555...4555555555555555 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   2.2    0.0012       2.6      11      81 ..      96     166 ..      68     193 .. 0.88
   2 ?    2.1   0.5     0.083   1.9e+02      91     115 ..     286     310 ..     280     325 .. 0.50

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0012
  TPR_MLP1_2  11 kslkeekeeaeaklqklqedlekqaeiakeaqqkYerelvkhaedvkelqalreelnelkaeiaelkaeae 81 
                 +++++++ +  ++  k+  d+++ +e   +  ++Yere vk ++++++l++  e+l + k++++e+ +  e
  EFC36897.1  96 QEMEKSNVKFVEESDKMNGDVNELQEGSVNLLDRYEREFVKLEAELRNLSDGIEQLVSQKSKAEEFLQVIE 166
                 667777888889999999*********************************99999999999998766655 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.083
  TPR_MLP1_2  91 eesweeqkeelekelselekriedl 115
                  ++ ++q  ele  ++++++r+ dl
  EFC36897.1 286 SKKVNQQVRELEMTIENSKSRLLDL 310
                 3444444444444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (852 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1423  (0.0793686); expected 358.6 (0.02)
Passed bias filter:                      789  (0.0440069); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.51
# Mc/sec: 4982.78
//
Query:       EFC36898.1  [L=1127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0011   18.5   0.4      0.085   12.7   0.0    3.3  3  IQ        IQ calmodulin-binding motif


Domain annotation for each model (and alignments):
>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.0   4.8e-06     0.085       3      19 ..     528     544 ..     526     545 .. 0.88
   2 ?   -0.4   0.1     0.079   1.4e+03       7      21 .]     578     592 ..     577     592 .. 0.88
   3 ?    1.2   0.2     0.023   4.2e+02       6      14 ..     689     697 ..     688     701 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.8e-06
                 HHHHHHHHHHHHHHHHH CS
          IQ   3 aaikIQaawRGylaRkr 19 
                 + ++IQ+ +RGy+ Rk+
  EFC36898.1 528 SSLVIQSLFRGYVERKK 544
                 6689***********97 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.079
                 HHHHHHHHHHHHHHH CS
          IQ   7 IQaawRGylaRkryk 21 
                  Qa   G ++R++++
  EFC36898.1 578 VQAILLGSQTRRQFH 592
                 69999999*****96 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.023
                 HHHHHHHHH CS
          IQ   6 kIQaawRGy 14 
                  +Qa +RG 
  EFC36898.1 689 QLQALCRGR 697
                 69******6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1053  (0.0587317); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.79u 0.36s 00:00:01.14 Elapsed: 00:00:00.56
# Mc/sec: 6015.14
//
Query:       EFC36899.1  [L=462]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-06   28.6   2.3    4.6e-06   26.9   2.3    2.0  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   2.3   2.5e-10   4.6e-06       2     116 ..      16     157 ..      15     159 .. 0.89

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 2.5e-10
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS................................SHHHHHHHHHHHHHHHHTSTTSTTSSTS CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka................................keqeelkkkakeIyneylapsspkelni 68 
                 +e +l+++  r++F++Fl++  +ee l F++   e+ +                                   ++e++ ++++I++++++ +s+kelni
  EFC36899.1  16 YEAVLDNKEARKIFQDFLQDCRNEEPLLFLDTYAEYFSGyeqvlkevfggwadeekvslknssnsskqnknLFRNEVILRVEKIIQTFIEYHSEKELNI 114
                 6789*******************************9999999***********************998877777888888******************* PP

                 -HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS  69 dkklreelekrlekeqpsrklfeeaqeevfellekdsypkFlkselyl 116
                   +    l+ + +    +++l++   +  ++ l+ d++p+F++se+ +
  EFC36899.1 115 GTSQSWLLN-YWKL--AKEDLLDTFIT--LTDLKMDQFPRFVRSEKLR 157
                 988765555.5555..68999999886..678999*********9866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (462 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       539  (0.030063); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 2545.20
//
Query:       EFC36900.1  [L=503]
Description: regulator of G protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.9e-11   42.3   0.3      1e-09   38.7   0.3    2.6  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.7   0.3   5.6e-14     1e-09       2     117 ..      14     201 ..      13     202 .. 0.90

  Alignments for each domain:
  == domain 1  score: 38.7 bits;  conditional E-value: 5.6e-14
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS................................SHHHHHHHHHHHHHHHHTSTTSTTSSTS CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka................................keqeelkkkakeIyneylapsspkelni 68 
                 ++ +l+++  r++F eFl ++ +ee l F+++ +e+ ++                                  + e++ +a++I+n++l++ s++elni
  EFC36900.1  14 YDAVLDNKEARRIFHEFLIENRDEEPLVFLDHYNEYCHNyehvlkevfggwsdyqiislkqssnsskqhnhLFRVEVIGRAESIINTFLEHYSERELNI 112
                 6789**********************************************************999987655556677778******************* PP

                 -HHHHHHHHHHHCSS.........................................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS  69 dkklreelekrleke.........................................qpsrklfeeaqeevfellekdsypkFlkselylr 117
                   + +  + ++ +++                                            + lf ++ ++v+  l+ d++p+F++se+ l+
  EFC36900.1 113 GTSQT-IVLNYWKDVkedlidvfldstvpgktrlsctssdyynlvteqieseimrrLHPEALFSKVLSSVHLDLKMDQFPRFVRSEKLLN 201
                 87654.3444444445669999********************************98777899************************9776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       711  (0.0396564); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 3224.78
//
Query:       EFC36901.1  [L=488]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.4e-09   36.6   0.0    1.6e-08   35.3   0.0    1.6  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
    0.00013   22.3   0.0    0.00037   20.8   0.0    1.7  1  2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
  ------ inclusion threshold ------
      0.028   14.7   0.0       0.16   12.2   0.0    2.1  1  PhyH            Phytanoyl-CoA dioxygenase (PhyH)


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.3   0.0   2.6e-12   1.6e-08       3      91 ..     320     421 ..     318     424 .. 0.84

  Alignments for each domain:
  == domain 1  score: 35.3 bits;  conditional E-value: 2.6e-12
                     EEEE.-TT-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--EEE...........................---TT-EEEEE-..B-TEEE CS
  2OG-FeII_Oxy_3   3 vlry.gegqeykpHvDnfekeegsgqrrltvllyLnekeseeGGelelyekdk.................eavkikpkkgrlvlFesdellpHev 79 
                     + ry g+  ++ pH D +  ++ +++ ++t++lyLn  ++++ G   + + ++                 ++ ++kpk+gr+++F+   l  H++
      EFC36901.1 320 CCRYnGPCVGFVPHRDGNFVQSVDERSKFTIILYLN--DNFDDGTTDFLRAHQpasmgelvreelergfsNEFSLKPKRGRVLIFDHALL--HQG 410
                     56787666789*****9887777799*********8..79889986665555567799999999999**99****************877..*** PP

                     --B.-SS-EEEE CS
  2OG-FeII_Oxy_3  80 lpvtkggeRlsl 91 
                     +p+ + g+++++
      EFC36901.1 411 RPIPS-GHKYII 421
                     **955.599987 PP

>> 2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   6.3e-08   0.00037      24      91 ..     349     415 ..     340     421 .. 0.87

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 6.3e-08
  2OG-FeII_Oxy_5  24 SgvyYlsvpkeagalkledprlavelgaparkeeakeenqslvdvkpkeGdlvlFPswlrHevlpneg 91 
                     + + Yl+ + ++g++++ + ++++++g+  r+e + +  ++++++kpk+G++++F   l H+  p  +
      EFC36901.1 349 TIILYLNDNFDDGTTDFLRAHQPASMGELVREELE-RGFSNEFSLKPKRGRVLIFDHALLHQGRPIPS 415
                     5689**********************999777655.599**********************9888765 PP

>> PhyH  Phytanoyl-CoA dioxygenase (PhyH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   2.7e-05      0.16      99     205 ..     323     415 ..     228     419 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.7e-05
                 -TTTCB-E.EEEE-SGGGSTEESGCCEEEEEEESS-B-TTBT-EEEETTGGGS-CCGTCCHHCSGCCTTSCCCTTTGHGSCEEEE.BTTTEEEEEETTS CS
        PhyH  99 qpkiGgev.qpwHqDstflptdpeesvvgvwialedateenGclrfiPGSHkweegplrrrlpeddteaeddeakkedeeeavpvevkaGdavlfhgrl 196
                 ++  G++v   +H+D  f++  +e+s  ++ ++l d   + G + f+   +  + g+l r+  e     +         ++  ++  k+G +++f+ +l
  EFC36901.1 323 YN--GPCVgFVPHRDGNFVQSVDERSKFTIILYLNDN-FDDGTTDFLRAHQPASMGELVREELER---GF---------SNEFSLKPKRGRVLIFDHAL 406
                 44..999999**********66667777777777776.7*********98888777654444444...44.........5669**************** PP

                 EEEE-TB.S CS
        PhyH 197 lHgsgaNrs 205
                 lH++++  s
  EFC36901.1 407 LHQGRPIPS 415
                 ***998766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       707  (0.0394333); expected 358.6 (0.02)
Passed bias filter:                      514  (0.0286686); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 3079.46
//
Query:       EFC36902.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.2e-14   52.2   0.0    7.3e-14   51.7   0.0    1.2  1  Putative_PNPOx   Pyridoxamine 5'-phosphate oxidase
      3e-13   49.6   0.3    5.1e-13   48.9   0.3    1.4  1  PNP_phzG_C       Pyridoxine 5'-phosphate oxidase C-terminal d
    1.5e-06   28.7   0.0    2.6e-06   28.0   0.0    1.4  1  Pyridox_oxase_2  Pyridoxamine 5'-phosphate oxidase


Domain annotation for each model (and alignments):
>> Putative_PNPOx  Pyridoxamine 5'-phosphate oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.7   0.0   1.2e-17   7.3e-14      10      88 .]      50     134 ..      39     134 .. 0.92

  Alignments for each domain:
  == domain 1  score: 51.7 bits;  conditional E-value: 1.2e-17
                     HHSSEEEEEEEE.TTSEEEEEEEEEEEETTT.TEEEEEEETTSHHHHHHHHH-EEEEEEEETT....GSEEEEEEEEEEEESCHH CS
  Putative_PNPOx  10 aeskavvlATvd.edGrPnvspvllkagdgr.dgivfatnadsrklrnleenprvallfldde....lgrgvrieGtaelvsdge 88 
                     ae+ ++++ATv+ +  +P+ + v lk ++ +   ++f tn  srk+ +++en+++al f++      + ++vrieG ae+ sd+e
      EFC36902.1  50 AEPATMTVATVNpKTLQPSTRNVFLKSFNVEtSEFIFCTNFNSRKGSEIAENSKIALNFYWSYgsvmSSKQVRIEGVAEFCSDEE 134
                     5889********6669************999999***********************************************9987 PP

>> PNP_phzG_C  Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.9   0.3   8.5e-17   5.1e-13       1      43 []     190     231 .]     190     231 .] 0.96

  Alignments for each domain:
  == domain 1  score: 48.9 bits;  conditional E-value: 8.5e-17
  PNP_phzG_C   1 WgGyrvvPeeiEFWqgrpsRlHdRfrYereeedgkWkierLsP 43 
                 WgG+rv+ ++iEFWq++ +Rl +R++Y++e+ d++Wk + L+P
  EFC36902.1 190 WGGVRVRAHCIEFWQSGDHRLANRIQYKKEQ-DNSWKSTTLYP 231
                 ***************************9876.78********9 PP

>> Pyridox_oxase_2  Pyridoxamine 5'-phosphate oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.0   4.4e-10   2.6e-06      21      98 ..      53     129 ..      39     131 .. 0.83

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 4.4e-10
                      GEEEEEEE-T.TS-EEEEEEE---B-TT...SS-.EEEEEETTSHHHHHHH.H--EEEEEEEET....TTTEEEEEEEEEEE CS
  Pyridox_oxase_2  21 tefqlaTvdeeegkPrvRtvvfRgfleekkeesdvltfttDvrseKvkqlessnaaveavfylk....etreQfRisGkafv 98 
                       ++++aTv++++ +P++R v +++f  e   +s+ + f+t   s+K ++++ +n+++ + fy +     +++Q Ri+G a +
       EFC36902.1  53 ATMTVATVNPKTLQPSTRNVFLKSFNVE---TSE-FIFCTNFNSRKGSEIA-ENSKIALNFYWSygsvMSSKQVRIEGVAEF 129
                      6789*****99**************997...456.99**************.78888887776523225789******8865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       532  (0.0296726); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1418.57
//
Query:       EFC36903.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0044   16.8   0.3     0.0057   16.4   0.3    1.2  1  Claudin_2        PMP-22/EMP/MP20/Claudin tight junction
  ------ inclusion threshold ------
      0.017   14.8   0.9       0.12   12.1   0.9    2.1  1  Neurensin        Neurensin
      0.039   14.2   0.3      0.052   13.7   0.3    1.1  1  L_HMGIC_fpl      Lipoma HMGIC fusion partner-like protein
      0.087   11.6   0.2       0.11   11.2   0.2    1.2  1  DUF2207          Predicted membrane protein (DUF2207)
      0.093   12.8   3.7       0.14   12.2   3.7    1.2  1  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe
       0.27   11.3   1.9       0.36   10.8   1.9    1.2  1  TMEM119          TMEM119 family
       0.41   11.1   7.1        1.6    9.2   7.2    1.8  2  DUF202           Domain of unknown function (DUF202)
        1.4    9.7   4.2         11    6.9   0.0    2.6  2  Cadherin_C_2     Cadherin cytoplasmic C-terminal


Domain annotation for each model (and alignments):
>> Claudin_2  PMP-22/EMP/MP20/Claudin tight junction
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.3   2.5e-06    0.0057      63     139 ..      37     123 ..      14     137 .. 0.62

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.5e-06
   Claudin_2  63 ltqasn...pfekkeeeivsisatsllalarfvqvlliLslvlivlavvlgllallkqsv...........lllkaagilfllagvlglla 139
                 +t +     + + k ++++ + +t ++ ++++   ++ +s++l+++ + +++ ++++ s             ll+a +ilfl  g+++l++
  EFC36903.1  37 ET-CTAettQIHSKPSNSFFTPKTKFILTIVS---VTAISFLLAFILISMTITFAICDSLfdfpdlengiyALLVAISILFLGIGIVTLIV 123
                 22.22221133333333333333433333333...4455666666555555555555555566699****999*********999999875 PP

>> Neurensin  Neurensin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.9   5.1e-05      0.12      43      95 ..     105     182 ..      27     185 .] 0.78

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.1e-05
   Neurensin  43 vslvvgtlvlllGvtallvGylvprrlelv.........................ksegelvvvDkqaiefnnaLdtl 95 
                 + +++++l+l +G+++l+vG+ + r   +v                         +   e++  D+  +++ + L+t+
  EFC36903.1 105 LLVAISILFLGIGIVTLIVGWRLWRGKYSVndegfvvnsrgdrinvlgdvknsddNLVTERSSSDEDNLRYSRSLKTF 182
                 567899***************888844444344445555555555556666555444455556666666666666665 PP

>> L_HMGIC_fpl  Lipoma HMGIC fusion partner-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.3   2.3e-05     0.052      49     132 ..      33     126 ..      18     131 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.3e-05
  L_HMGIC_fpl  49 qevelecgryaldflaipssaw...kaaavlvalgill......lllvlllslltlcrqsilkk..svfkicallqlvaglllllglllyPlgWd 132
                  +  +++c+  ++++++ ps  +   k+  +l++++++       + l+ ++  + +c  s+++       i all +++ l+l +g++   +gW+
   EFC36903.1  33 HIPTETCTAETTQIHSKPSNSFftpKTKFILTIVSVTAisfllaFILISMTITFAICD-SLFDFpdLENGIYALLVAISILFLGIGIVTLIVGWR 126
                  5566778888888888888774455555555555544400000333344444444454.565541123358999999**********99999997 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.2   5.1e-05      0.11     368     430 ..      51     127 ..      18     146 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 5.1e-05
     DUF2207 368 ergyfdkkgkkklkklsalglgliilglilillallllvll................lvfllilllillliaiivlllf 430
                 ++ +f+ k k +l+++s+ ++ ++++++++++ +   ++++                lv ++il+l+++++ +iv + +
  EFC36903.1  51 SNSFFTPKTKFILTIVSVTAISFLLAFILISMTIT--FAICdslfdfpdlengiyalLVAISILFLGIGIVTLIVGWRL 127
                 45677777555555555555555444444443333..3333689999***99887777777777777777777766655 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   3.7   6.2e-05      0.14      39      93 ..      65     130 ..      58     135 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.2e-05
  Phage_holin_3_6  39 llgaagvlallalllllvalalal..aa........lwlaali.vaavllvlagvlalvglkklkk 93 
                      ++ ++++  lla++l+++++ +a+  ++           a l+ + +++l +++v ++vg++ +++
       EFC36903.1  65 IVSVTAISFLLAFILISMTITFAIcdSLfdfpdlenGIYALLVaISILFLGIGIVTLIVGWRLWRG 130
                      44566666677777777777666644113444556444444554569999999*******997775 PP

>> TMEM119  TMEM119 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   1.9   0.00016      0.36      19      94 ..       6      85 ..       1      88 [. 0.81

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00016
     TMEM119 19 eaegssasspslpPprtPa.lsptsvgpqptalaGpkpptnfldGivdff...rqyvlliavvGslaflllfivcaalit 94
                ++++s++  ps+ P++t a l +ts +  pt +   +           ff    +++l i  v ++ fll fi+ +  it
  EFC36903.1  6 DTNQSTTERPSIDPTNTSAsLDTTSQQHIPTETCTAETTQIHSKPSNSFFtpkTKFILTIVSVTAISFLLAFILISMTIT 85
                77899999*******998658899999999988777666666677788994444899****************9988776 PP

>> DUF202  Domain of unknown function (DUF202)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.2     0.083   1.9e+02      36      57 ..      68      89 ..      45      99 .. 0.79
   2 ?    9.2   7.2   0.00073       1.6      17      63 ..      74     129 ..      59     132 .. 0.63

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.083
      DUF202 36 psalgkilglilivlgiltllv 57
                ++a++++l++ili ++i ++++
  EFC36903.1 68 VTAISFLLAFILISMTITFAIC 89
                4556788888888888888775 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00073
      DUF202  17 slalialglallrffl............tgepsalgkilglilivlgiltllvglvryl 63 
                 +la+i ++ +++                +++  al ++++++++++gi+tl+vg++ ++
  EFC36903.1  74 LLAFILISMTIT---FaicdslfdfpdlENGIYALLVAISILFLGIGIVTLIVGWRLWR 129
                 334444444443...034566666664333333344777999*************9886 PP

>> Cadherin_C_2  Cadherin cytoplasmic C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   3.8      0.42   9.5e+02       7      24 ..      65      80 ..      58      90 .. 0.60
   2 ?    6.9   0.0    0.0047        11      10      40 ..     106     136 ..     104     178 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.42
  Cadherin_C_2  7 viaLasvSflFLltvivl 24
                  ++++ ++Sfl  l++i++
    EFC36903.1 65 IVSVTAISFL--LAFILI 80
                  6788888865..333333 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0047
  Cadherin_C_2  10 LasvSflFLltvivlvavrlrkerksaalqk 40 
                   L ++S+lFL   iv ++v  r +r + ++++
    EFC36903.1 106 LVAISILFLGIGIVTLIVGWRLWRGKYSVND 136
                   789*******999999998877776655555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1055  (0.0588432); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1224.60
//
Query:       EFC36904.1  [L=176]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.16   12.0   1.7       0.22   11.5   1.7    1.2  1  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe


Domain annotation for each model (and alignments):
>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   1.7   1.2e-05      0.22      41      93 ..      79     139 ..      66     149 .. 0.62

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1.2e-05
  Phage_holin_3_6  41 gaagvlallalllllvala......lalaa....lwlaali.vaavllvlagvlalvglkklkk 93 
                        +  +  ++ll+ +v +a      +   a       a +i + a++l++++v  lvg+k +++
       EFC36904.1  79 TCTSCFIGISLLISTVIVAvmhsldY---AqahgEIYALMIsISAFFLAVGLVTTLVGIKMWRG 139
                      33444444444444444432322222...244677777788789****************8887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1234  (0.068827); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1191.41
//
Query:       EFC36905.1  [L=388]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.1e-45  151.0  11.9    2.6e-11   43.1   0.2    5.6  5  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.2   1.3e-07    0.0023      14      49 .]      45      81 ..      32      81 .. 0.92
   2 !   42.7   0.3   1.9e-15   3.4e-11       1      43 [.     179     221 ..     179     226 .. 0.94
   3 !   41.1   0.0   5.9e-15   1.1e-10       1      49 []     204     252 ..     204     252 .. 0.97
   4 !   43.1   0.2   1.4e-15   2.6e-11       1      35 [.     254     288 ..     254     294 .. 0.96
   5 !   30.9   0.1   8.9e-12   1.6e-07      14      39 ..     298     323 ..     289     346 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.3e-07
     DUF4116 14 salkylseeLknDkeivlkAvkqng.talsyaseeLr 49
                ++++y++ e+ +Dk ++++ +k+n+  ++++++++L+
  EFC36905.1 45 KSYEYFPIEYAKDKSFIIENMKNNPqMVYEMIDPMLK 81
                58***********************779****99996 PP

  == domain 2  score: 42.7 bits;  conditional E-value: 1.9e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 Dr i+ e+vk ng++l++++++LknD+e +lkAv+ +g +l+ 
  EFC36905.1 179 DRLIIEECVKYNGFSLNFANNDLKNDREMILKAVRVDGLVLRD 221
                 9*************************************99975 PP

  == domain 3  score: 41.1 bits;  conditional E-value: 5.9e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE++l+av+ +g++l+ l ++++ D++iv++Avk+ng+++   + e+r
  EFC36905.1 204 DREMILKAVRVDGLVLRDLEKRWSTDRDIVIEAVKRNGNIIAKTPSEFR 252
                 9***************************************999998887 PP

  == domain 4  score: 43.1 bits;  conditional E-value: 1.4e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 DrEiv  a+k+n+++l+yls e+knD+eivl Av+
  EFC36905.1 254 DREIVFLALKSNSMCLEYLSGEMKNDREIVLLAVR 288
                 9********************************98 PP

  == domain 5  score: 30.9 bits;  conditional E-value: 8.9e-12
     DUF4116  14 salkylseeLknDkeivlkAvkqngt 39 
                 s+l+y+s+ Lk+D+e++l+Avk n++
  EFC36905.1 298 SCLRYASDLLKCDREVILEAVKHNPY 323
                 79**********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (388 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       517  (0.028836); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.25s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 2809.70
//
Query:       EFC36906.1  [L=214]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.6e-09   36.0   0.8    1.1e-08   35.0   0.8    1.6  1  COMM_domain  COMM domain
     0.0012   18.5   0.0     0.0062   16.2   0.0    2.0  2  DUF4035      Protein of unknown function (DUF4035)


Domain annotation for each model (and alignments):
>> COMM_domain  COMM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.0   0.8   1.3e-12   1.1e-08       1      70 [.     149     214 .]     149     214 .] 0.96

  Alignments for each domain:
  == domain 1  score: 35.0 bits;  conditional E-value: 1.3e-12
  COMM_domain   1 lpqLvdldWrldvqlsssslskvneptalleLklqngsgnsenvtlelskeqLqeLlneLeeiqkqlesl 70 
                  lp+L+ ldW+l + +sss ++ +++  +++ L ++n++      t+ ls ++++++++e+ ++   ++sl
   EFC36906.1 149 LPRLKHLDWKLSISTSSSDCEDLQTAKVTVTLLMTNSQR----KTIDLSLSEFKKMYSEFSDMAGLIDSL 214
                  79**********************************888....*******************99999886 PP

>> DUF4035  Protein of unknown function (DUF4035)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.24   2.1e+03      22      41 ..      76      95 ..      73      98 .. 0.81
   2 !   16.2   0.0     7e-07    0.0062      13      46 ..     169     202 ..     166     206 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.24
     DUF4035 22 hllaminrdskgkkpsLsdf 41
                 ll+ i r +++  + L++f
  EFC36906.1 76 NLLLYIFRTARQYRVPLAEF 95
                45666999999999999987 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 7e-07
     DUF4035  13 eDyrtAqishllaminrdskgkkpsLsdfmlfwn 46 
                 eD +tA++   l+m n++ k+  +sLs+f  +++
  EFC36906.1 169 EDLQTAKVTVTLLMTNSQRKTIDLSLSEFKKMYS 202
                 8***************************976665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       663  (0.0369792); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.42u 0.28s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 1517.88
//
Query:       EFC36907.1  [L=261]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0016   18.8   0.1       0.13   12.6   0.0    2.7  3  DUF2369   Uncharacterised conserved protein (DUF2369)


Domain annotation for each model (and alignments):
>> DUF2369  Uncharacterised conserved protein (DUF2369)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.0   0.0    0.0075   1.4e+02      67      95 .]      11      39 ..       5      39 .. 0.83
   2 ?   -2.8   0.0      0.48   8.7e+03      16      24 ..     100     108 ..      96     112 .. 0.81
   3 !   12.6   0.0   7.4e-06      0.13       8      41 ..     198     231 ..     193     240 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.0075
     DUF2369 67 gkkgkslfsfkvpsnaqqsvklllqsCsg 95
                +++ + l++fk    ++ ++++++ +C+g
  EFC36907.1 11 SNGMTNLYKFKTDPVTSSNLMVFVLPCEG 39
                55566699999998899**********86 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.48
     DUF2369  16 pdtqYyfdV 24 
                  +++Yy+ V
  EFC36907.1 100 GNSTYYLKV 108
                 578999987 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 7.4e-06
     DUF2369   8 kvtlseLkpdtqYyfdVFvvdqkrntssaytgtt 41 
                 +  + +Lk++  Y++dV +  + +++s ay g+ 
  EFC36907.1 198 TSFVLNLKKSAAYHIDVVATRKDNGRSWAYIGQE 231
                 455779*************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.58
# Mc/sec: 1359.40
//
Query:       EFC36908.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1804  (0.100619); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 2082.69
//
Query:       EFC36909.1  [L=321]
Description: hypothetical protein NAEGRDRAFT_82089 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1800  (0.100396); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 2122.49
//
Query:       EFC36910.1  [L=242]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-05   24.0   0.0    0.00029   20.9   0.0    2.4  3  Acetyltransf_CG  GCN5-related N-acetyl-transferase
     0.0029   18.0   0.2      0.015   15.7   0.2    2.1  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
     0.0037   17.3   0.0       0.13   12.4   0.0    2.4  2  Acetyltransf_9   Acetyltransferase (GNAT) domain
     0.0062   16.8   0.1      0.016   15.5   0.1    1.8  1  Acetyltransf_1   Acetyltransferase (GNAT) family


Domain annotation for each model (and alignments):
>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.2   5.2e+03      47      75 ..      68      96 ..      63      99 .. 0.72
   2 !   20.9   0.0   6.5e-08   0.00029      23      54 ..     138     169 ..     121     172 .. 0.90
   3 ?   -0.6   0.1      0.34   1.5e+03      48      78 ..     177     207 ..     174     211 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.2
  Acetyltransf_CG 47 kaalddareeglkvvptCsyvaaylekhp 75
                       a+d a  +   v+++  y+++++   p
       EFC36910.1 68 HVAIDTATGKLIGVIISEDYAKSFFATIP 96
                     55777777777778888888888887666 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 6.5e-08
  Acetyltransf_CG  23 gvldfthTeVpeelrGkGiAkkLvkaalddar 54 
                      ++l+++ T V  e+rGkGiA++L+k  +d+a+
       EFC36910.1 138 KILHLNCTSVYAEYRGKGIASQLTKIHFDYAK 169
                      5789999***********************98 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.34
  Acetyltransf_CG  48 aalddareeglkvvptCsyvaaylekhpeya 78 
                      a+ +++ ++ ++++ +  +v++ + k+ ey+
       EFC36910.1 177 AVAECTSHTSKSIKEQHNFVSKAVVKYSEYE 207
                      5667777788888888888888888888885 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.2   3.4e-06     0.015      26      51 ..     141     175 ..      52     201 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3.4e-06
                     CTEEEEE-GGGTTSSHHHHHHHH.....TT....S CS
  Acetyltransf_7  26 eitrlaVdpeyrgkGiGraLlea.....ae....k 51 
                     ++++  V  eyrgkGi+++L ++     ++    k
      EFC36910.1 141 HLNCTSVYAEYRGKGIASQLTKIhfdyaKNvlgfK 175
                     344467999***********994345541142333 PP

>> Acetyltransf_9  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.032   1.4e+02       2      26 ..      14      38 ..      13      82 .. 0.86
   2 !   12.4   0.0   2.8e-05      0.13      79     103 ..     145     169 ..     137     172 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.032
                    EEEE-GGGHHHHHHHHHHHTT---- CS
  Acetyltransf_9  2 irelteedldevlellkyaFqdees 26
                    +  lt e lde+++ l+y F+ +e+
      EFC36910.1 14 YQLLTAEYLDEAVQCLAYTFGTSEP 38
                    66789999************99886 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 2.8e-05
                     EEE-CCGTTS-HHHHHHHHHHHHHH CS
  Acetyltransf_9  79 VavapehrgrgvlskLlaraleemr 103
                     ++v++e+rg+g++s+L++ ++++++
      EFC36910.1 145 TSVYAEYRGKGIASQLTKIHFDYAK 169
                     69****************9999987 PP

>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   3.5e-06     0.016      42     105 ..      76     185 ..      36     191 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 3.5e-06
                     TEEEEEE......................................EEEEEET............TSTTEEEEEEEEESGGGTTSSHHHHHHHHHH CS
  Acetyltransf_1  42 geliGfi......................................sllkipd............ekggvayieslaVspeyrgkGlGsaLleale 86 
                     g+liG i                                                           g+  +++   V  eyrgkG++s+L +   
      EFC36910.1  76 GKLIGVIisedyaksffatipeklmenkkigrvikvlellhekffH-----AnperekeiknseSFGKILHLNCTSVYAEYRGKGIASQLTKIHF 165
                     5555555555555555555555555555555445544444444331.....0223334444455667888899999******************* PP

                     HHHHHT.TESEEEEEEETTE CS
  Acetyltransf_1  87 eraree.gikkivlaveedn 105
                     ++a++  g+k  v++++++ 
      EFC36910.1 166 DYAKNVlGFKGAVAECTSHT 185
                     ****9999977677666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (242 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1475.51
//
Query:       EFC36911.1  [L=179]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-43  148.7   0.3    1.3e-43  148.5   0.3    1.0  1  Arf           ADP-ribosylation factor family
    1.5e-11   44.4   0.1    2.4e-11   43.7   0.1    1.3  1  MMR_HSR1      50S ribosome-binding GTPase
    1.6e-11   44.5   0.0    2.3e-11   43.9   0.0    1.2  1  Roc           Ras of Complex, Roc, domain of DAPkinase
    3.4e-11   43.0   0.0    3.9e-11   42.8   0.0    1.1  1  Ras           Ras family
    1.2e-10   41.1   0.0    1.5e-10   40.8   0.0    1.1  1  Gtr1_RagA     Gtr1/RagA G protein conserved region
    1.5e-10   40.8   0.7    1.2e-06   28.0   0.1    2.6  2  G-alpha       G-protein alpha subunit
    8.9e-10   38.4   0.4      3e-08   33.5   0.0    2.0  2  GTP_EFTU      Elongation factor Tu GTP binding domain
    4.1e-08   32.9   0.0    5.4e-08   32.5   0.0    1.2  1  SRPRB         Signal recognition particle receptor beta subun
    6.5e-05   22.5   2.1    0.00034   20.2   2.1    2.1  1  FeoB_N        Ferrous iron transport protein B
      0.003   17.4   0.0        0.6    9.8   0.0    2.1  2  ATP_bind_1    Conserved hypothetical ATP binding protein
     0.0056   16.3   0.4        2.6    7.6   0.1    2.2  2  cobW          CobW/HypB/UreG, nucleotide-binding domain
  ------ inclusion threshold ------
       0.02   14.8   1.0        3.9    7.4   0.1    2.3  2  RsgA_GTPase   RsgA GTPase
      0.027   14.5   0.3      0.055   13.5   0.3    1.6  1  MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
      0.028   14.5   0.0          3    7.9   0.1    2.2  2  Dynamin_N     Dynamin family
       0.04   13.8   0.1        4.4    7.2   0.1    2.1  2  NACHT         NACHT domain
      0.041   13.4   0.0      0.057   12.9   0.0    1.2  1  AAA_7         P-loop containing dynein motor region
      0.068   12.9   0.2       0.37   10.5   0.2    2.3  1  PduV-EutP     Ethanolamine utilisation - propanediol utilisat
       0.13   12.7   0.1       0.18   12.3   0.1    1.4  1  ABC_tran      ABC transporter
       0.19   11.5   1.6        1.2    9.0   0.8    2.5  2  NOG1          Nucleolar GTP-binding protein 1 (NOG1)
        0.2   11.8   0.1        1.1    9.4   0.0    1.9  2  AAA_33        AAA domain


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  148.5   0.3   1.5e-46   1.3e-43       8     174 ..      11     177 ..       2     178 .. 0.95

  Alignments for each domain:
  == domain 1  score: 148.5 bits;  conditional E-value: 1.5e-46
                 GTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHH CS
         Arf   8 lklkkkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLka 106
                 l++  k++ il++GL n+GKtT+l+ ++++e  +t PT+g n+++++   ++++v D+GGqe+ R+lW + +++ d+v+fvvD ad +++ +a++eL++
  EFC36911.1  11 LFN-GKQIEILMVGLANSGKTTLLNVISDNEPGDTLPTVGVNMRHVKKGSVTMKVLDLGGQERFRNLWLEHTKSCDVVVFVVDGADIDKVPDARRELHK 108
                 444.79********************************************************************************************* PP

                 HCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSS.SSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 107 lleeeelkevallvlaNKqDlpealseeelrellgleelk.gkrkleiqkcsavkgeglkeglewlses 174
                 lle++ l+  +llv+ NK+D++   +++++ ++l+l+ +  +k+++ ++  sa++++++++ ++wl ++
  EFC36911.1 109 LLENKGLEGKPLLVVLNKIDIERRFTKDDIVKHLNLDYIDnNKNPWAVIPISALHKTNITDVVDWLLKQ 177
                 ***************************************967889*********************875 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.7   0.1   2.7e-14   2.4e-11       1     114 []      18     126 ..      18     126 .. 0.80

  Alignments for each domain:
  == domain 1  score: 43.7 bits;  conditional E-value: 2.7e-14
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSS...SEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT.TTCSHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTr...dinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas.eeklkpld 94 
                 e++ vG  N+GK+tL+n ++++      +pg T+    +n ++vk++   ++++D+ G  e      ++++ +l++ + +d++++vvd +  +k+ + +
  EFC36911.1  18 EILMVGLANSGKTTLLNVISDN------EPGDTLptvGVNMRHVKKGSVTMKVLDLGG-QE------RFRNLWLEHTKsCDVVVFVVDGAdIDKVPDAR 103
                 5899**************9985......4444440004566666655588********.44......89******99978********55533678889 PP

                 HHHHHHHHH...TTSEEEEEEES CS
    MMR_HSR1  95 eeleellee...akkplilvlnk 114
                 +el++lle+   ++kpl++vlnk
  EFC36911.1 104 RELHKLLENkglEGKPLLVVLNK 126
                 999999988999**********8 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.9   0.0   2.6e-14   2.3e-11       2     119 ..      19     128 ..      18     129 .. 0.77

  Alignments for each domain:
  == domain 1  score: 43.9 bits;  conditional E-value: 2.6e-14
                 EEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHHHHH CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssenlkeWlk 100
                 +++vG +++GKt+ll+ + +++   ++ +t+gv++ +  v   k+        +v++++ D++Gqerfr+l   + ++ +++++v+d  + +++ +  +
  EFC36911.1  19 ILMVGLANSGKTTLLNVISDNE-PGDTLPTVGVNMRH--V---KK-------GSVTMKVLDLGGQERFRNLWLEHTKSCDVVVFVVDGADIDKVPDARR 104
                 799************9887555.57889******964..3...22.......3699*******************************776666554444 PP

                 HHHHHCS.....SS-EEEEEE-TT CS
         Roc 101 elkkvag.....kspvilvgnkiD 119
                 el+k  +      +p+++v nkiD
  EFC36911.1 105 ELHKLLEnkgleGKPLLVVLNKID 128
                 4444433001114699*******9 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.8   0.0   4.4e-14   3.9e-11       2     159 ..      19     177 ..      18     179 .] 0.78

  Alignments for each domain:
  == domain 1  score: 42.8 bits;  conditional E-value: 4.4e-14
                 EEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHH CS
         Ras   2 lvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrv 100
                 +++vG  + GKt+ll+   +++ + +  +T+gv+      +v++ +v+++++D  Gqe+f++l     +++++++ v d  + +   +++   +e+++ 
  EFC36911.1  19 ILMVGLANSGKTTLLNVISDNE-PGDTLPTVGVNMR----HVKKGSVTMKVLDLGGQERFRNLWLEHTKSCDVVVFVVDGADIDKVPDAR---RELHKL 109
                 789************9977777.77889***88764....688999*****************999988888777666655555555555...555554 PP

                 ST....TTSEEEEEEETTTGGG....G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHH CS
         Ras 101 ae....envpivLvGnKvDlee....kravsteegeelakelg.lkfletSAktnenveeafeellre 159
                  e    e  p+++v nK+D+e+    +  v+  +   + ++++  + + +SA +++n++++++ ll++
  EFC36911.1 110 LEnkglEGKPLLVVLNKIDIERrftkDDIVKHLNLDYIDNNKNpWAVIPISALHKTNITDVVDWLLKQ 177
                 444448899************9888444555555555555555788899************9999886 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.8   0.0   1.7e-13   1.5e-10       2     146 ..      19     152 ..      18     170 .. 0.82

  Alignments for each domain:
  == domain 1  score: 40.8 bits;  conditional E-value: 1.7e-13
   Gtr1_RagA   2 vLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletlk 99 
                 +L++G  +sGKt++ ++i dn  + dtl    t+ v+  +v+  g +t++++D+gGqe+f +  l++      ++++v+++V+D  + + ++++ ++l+
  EFC36911.1  19 ILMVGLANSGKTTLLNVISDN-EPGDTL---PTVGVNMRHVK-KGSVTMKVLDLGGQERFRNLWLEH-----TKSCDVVVFVVDGADIDkVPDARRELH 107
                 89****************988.678887...699999****6.99***************9887555.....4689********997755999999999 PP

   Gtr1_RagA 100 eilealrqyspeakvfvlihKmDliqedereeifeerkeeireeiek 146
                 ++le+     +   + v ++K+D  ++ ++++i+++ + +++++ ++
  EFC36911.1 108 KLLENK--GLEGKPLLVVLNKIDIERRFTKDDIVKHLNLDYIDNNKN 152
                 998874..4456668899***************99999888877764 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.1   0.00031      0.28      22      43 ..      15      36 ..      10      41 .. 0.88
   2 !   28.0   0.1   1.3e-09   1.2e-06     186     281 ..      45     129 ..      41     159 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00031
                .EEEEEEEESTTSSHHHHHHHH CS
     G-alpha 22 revkllllGqseSGKsTilkql 43
                +++ +l++G + SGK+T+l+ +
  EFC36911.1 15 KQIEILMVGLANSGKTTLLNVI 36
                5799**************9866 PP

  == domain 2  score: 28.0 bits;  conditional E-value: 1.3e-09
                 ----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHH CS
     G-alpha 186 lktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDi 281
                 l+tvG++  +++ + +++++++d+gGq   r+ W+++ ++ d+++F+v  +++d+v              +  +++++nk l+ +p++++lnK+Di
  EFC36911.1  45 LPTVGVNMRHVKKG-SVTMKVLDLGGQERFRNLWLEHTKSCDVVVFVVDGADIDKVPDA----------RRELHKLLENKGLEGKPLLVVLNKIDI 129
                 68999999999988.**************************************996544..........445678899*****************9 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.047        42       5      23 ..      18      36 ..      15      44 .. 0.83
   2 !   33.5   0.0   3.3e-11     3e-08      63     190 ..      55     176 ..      38     179 .] 0.78

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.047
                EEEEEESTTSSHHHHHHHH CS
    GTP_EFTU  5 nigiighvDhGKtTLtdrL 23
                 i ++g  ++GKtTL+  +
  EFC36911.1 18 EILMVGLANSGKTTLLNVI 36
                67889999*******9876 PP

  == domain 2  score: 33.5 bits;  conditional E-value: 3.3e-11
                 EETTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETT..TBSTHHHHHHHHHHHHTTTE...EEEEEESCGSTHHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  63 leketkkylinliDtPGHvdFskevirglrvlDgavlvvdav..eGvepqteevlrlalkegvp...iivfiNKmDrlkaelkeiveevkqklsrkeek 156
                 +  ++ + +++++D  G + F +   + ++ +D++v+vvd +  + v    +e+ +l+ ++g++   + v++NK+D      + +++++ ++l     +
  EFC36911.1  55 V--KKGSVTMKVLDLGGQERFRNLWLEHTKSCDVVVFVVDGAdiDKVPDARRELHKLLENKGLEgkpLLVVLNKIDIE---RRFTKDDIVKHL-----N 143
                 3..47788999*****************************984445778888888888888877777*********74...445566777777.....4 PP

                 HHHHHHTTTTTEEEEEEBTTTTBTHHHHHHHHHH CS
    GTP_EFTU 157 lekygekgekevpvvfgSalkgegvktllealve 190
                 l+ +  ++ +   v+++Sal++ +++++++ l +
  EFC36911.1 144 LDYIDNNK-NPWAVIPISALHKTNITDVVDWLLK 176
                 44445454.6999*************99998765 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.5   0.0     6e-11   5.4e-08       3     123 ..      16     128 ..      14     144 .. 0.74

  Alignments for each domain:
  == domain 1  score: 32.5 bits;  conditional E-value: 6e-11
                 --EEEEE-STTSSHHHHHHHHHHSS---B---SS-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHHHH CS
       SRPRB   3 kpavllvGlsdsGKTslftrLttdsvkktvtSqessaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEllye 101
                 +  +l+vGl +sGKT+l++ ++ ++  +t   +  ++ +    +   +++++D+ G+e++r+  le+    +s   +vfvvD +    +v +    l +
  EFC36911.1  16 QIEILMVGLANSGKTTLLNVISDNEPGDTLPTVGVNMRHVK--KGSVTMKVLDLGGQERFRNLWLEH---TKSCDVVVFVVDGAD-IDKVPDARRELHK 108
                 5679********************99999988744443322..35678999**********999988...778899******864.4445555555555 PP

                 HHHHHHHHTT---EEEEEE-TT CS
       SRPRB 102 illiteklkdavdiliACnKqe 123
                 +l ++    ++ ++l+  nK +
  EFC36911.1 109 LLENKG--LEGKPLLVVLNKID 128
                 554443..34555666666655 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   2.1   3.8e-07   0.00034       2     153 ..      18     171 ..      17     174 .. 0.64

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 3.8e-07
                 EEEEEESTTSSHHHHHHHHHTTSEEEEESTTSSSEEEEEEEEETTEEEEEEE----SSSSSSSHHHHHHHHHHHCTSSSEEEEEEEGGGH......HHH CS
      FeoB_N   2 tvalvGnpnvGkttlfnaltgakqkvgNwpGvtvekkegklklkgkeveivDlPGiYslsayseeekvardflleeepdvvvnvvdatnl......ern 94 
                 ++ +vG  n+Gkttl+n +++ +      p v v+ +  ++k  + +++++Dl G   + +   e + ++d+        vv vvd + +      +r+
  EFC36911.1  18 EILMVGLANSGKTTLLNVISDNEP-GDTLPTVGVNMR--HVKKGSVTMKVLDLGGQERFRNLWLEHTKSCDV--------VVFVVDGADIdkvpdaRRE 105
                 7899***************98654.345666666555..55555899********98888888887665555........5555554444111111467 PP

                 HHHHHHHHHTT.SSEEEEEETHHHHHHTT.....EEE-HHHHHHHHT.S-EEEEBTTTTBTHHHHH CS
      FeoB_N  95 LyLtlqllelg.vpvvlalnmideaekkg.....ieidlkkLsekLg.vpvvktsakkkegieell 153
                 L+ +l+   l+ +p++++ln+id  ++        +++l+ ++++ +   v+++sa +k++i +++
  EFC36911.1 106 LHKLLENKGLEgKPLLVVLNKIDIERRFTkddivKHLNLDYIDNNKNpWAVIPISALHKTNITDVV 171
                 76666666664499*********8765331111123444444443333678888888887777765 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   0.0    0.0097       8.7       2      23 ..      22      43 ..      21      55 .. 0.77
   2 !    9.8   0.0   0.00067       0.6      92     186 ..      61     147 ..      47     174 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0097
  ATP_bind_1  2 vGpaGsGKttfvgalseilelr 23
                vG a sGKtt+ + +s+  +  
  EFC36911.1 22 VGLANSGKTTLLNVISDNEPGD 43
                89**********9999876655 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00067
  ATP_bind_1  92 dyllfDtPGQielfthseslakiveeLesefalvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek.lekeleffedveal 186
                    ++D  GQ ++ +++ +          +   vvv++vD   ++++ +   +l+  l      + P +vvlnk+D+ + + ++ ++    +++++
  EFC36911.1  61 TMKVLDLGGQERFRNLWLEHT--------KSCDVVVFVVDGADIDKVPDARRELHKLLENKGLEGKPLLVVLNKIDIER-RfTKDDIVKHLNLDYI 147
                 556789999999999998888........678899***********999999999999999999*************55.3455555555545444 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.1    0.0029       2.6       5      27 ..      21      43 ..      18      61 .. 0.81
   2 !    7.1   0.0    0.0043       3.8     109     152 ..      81     129 ..      70     147 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0029
                EEESTTCCHHHHHHHHHCT--SS CS
        cobW  5 ltGflGsGKTtLlnhllenragl 27
                ++G   sGKTtLln + +n+ g 
  EFC36911.1 21 MVGLANSGKTTLLNVISDNEPGD 43
                678888********998777665 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0043
                 CCCECEEEEEEETTTH.....CCHCCHHHHHHHHHHTSS.EEEEE-HHH CS
        cobW 109 dltldavvavvDaknl....eaeeekieekaedqlaaad.llvlnKtDl 152
                     d+vv+vvD++ +    +a++e  + + +++l+    l+vlnK+D 
  EFC36911.1  81 TKSCDVVVFVVDGADIdkvpDARRELHKLLENKGLEGKPlLVVLNKIDI 129
                 567899*******9998885444444444555666644326889***97 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.1    0.0043       3.9     102     123 ..      19      40 ..       2      67 .. 0.69
   2 ?    6.6   0.1    0.0075       6.7      33      98 ..     104     175 ..      70     179 .] 0.65

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0043
                  EEEECSTTSSHHHHHHHHCTT- CS
  RsgA_GTPase 102 svlvGqSGvGKStLinallpel 123
                  +++vG    GK+tL+n++  ++
   EFC36911.1  19 ILMVGLANSGKTTLLNVISDNE 40 
                  45689999**********9874 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0075
                  HHHHHHHHHHHHTT-EEEEEEE-GGG--HHH........HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCT CS
  RsgA_GTPase  33 nlldrfLvlaeekgiepvivlnKiDlleeee........eleelkeelealgyevllvsaktkegleelkellk 98 
                  + l+++L     +g ++++vlnKiD+  + +        +l+ +    ++   +v+ +sa +k++++++ ++l 
   EFC36911.1 104 RELHKLLENKGLEGKPLLVVLNKIDIERRFTkddivkhlNLDYID--NNKNPWAVIPISALHKTNITDVVDWLL 175
                  4566666666667778999******98776645544422222222..233334777788888888888877775 PP

>> MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.3   6.1e-05     0.055      56      98 ..     118     172 ..      78     178 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 6.1e-05
  MMR_HSR1_Xtn  56 ipclyvlNKiDl.........isleeldelare...........p.nsvviSaekelnldeLke 98 
                   +p l+vlNKiD          +         ++           p  +++iSa +++n+ ++++
    EFC36911.1 118 KPLLVVLNKIDIerrftkddiV---------KHlnldyidnnknPwAVIPISALHKTNITDVVD 172
                   689********96665444443.........322333455555535999**********98876 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.1    0.0034         3       1      22 [.      19      40 ..      19      52 .. 0.85
   2 ?    4.8   0.0     0.029        26     120     167 ..      75     126 ..      47     127 .. 0.75

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0034
                EEEEEBTTTTHHHHHHHHHTS- CS
   Dynamin_N  1 iavvGsqSsGKSSvlnaLlged 22
                i+ vG  +sGK+++ln +   +
  EFC36911.1 19 ILMVGLANSGKTTLLNVISDNE 40
                7889************998765 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.029
                 HHHHHHHSTTEEEEEEEETTS.-CCC-CHHHHHHHHSTTBTT...EEEEEE- CS
   Dynamin_N 120 elvkeyikkadiilavtsanh.dlsnsealflarevdpkgkr...tivvltk 167
                 +l  e+ k++d++++v++    d     +++l++++++kg      +vvl+k
  EFC36911.1  75 NLWLEHTKSCDVVVFVVDGADiDKVPDARRELHKLLENKGLEgkpLLVVLNK 126
                 8889999*********975543777778888888888888777779999998 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.026        23       3      22 ..      19      38 ..      18      52 .. 0.84
   2 ?    7.2   0.1    0.0049       4.4      73     126 ..      77     123 ..      60     145 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.026
                EEEEC-TTTCHHHHHHHHHH CS
       NACHT  3 vilqGeaGsGKTtLlqklal 22
                +++ G a sGKTtLl  + +
  EFC36911.1 19 ILMVGLANSGKTTLLNVISD 38
                57889999*******98876 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0049
                 HHHHCCSCCCEEEEEE-STT-SS-TCH.........HHHHHCTTTTT--EEEEE CS
       NACHT  73 wavllelperlLlilDglDelvtdlgqkekqpvrtlLselirkkllpeaslllt 126
                 w + ++  + +++++Dg+D   + +++      r+ L++l++ k l + +ll+ 
  EFC36911.1  77 WLEHTKSCDVVVFVVDGADI-DKVPDA------RRELHKLLENKGLEGKPLLVV 123
                 444455566788*****995.445666......788999999999999999986 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   6.3e-05     0.057      25      89 ..       8      72 ..       3      94 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 6.3e-05
       AAA_7 25 llelllknkkpvllvGptGtGKtviikdllkkldkekylsltinfsaqtsanqlqdiiesklekr 89
                l el+  ++ ++l+vG + +GKt++++ + ++ + +++ ++ +n+ +  + + ++++++   + r
  EFC36911.1  8 LWELFNGKQIEILMVGLANSGKTTLLNVISDNEPGDTLPTVGVNMRHVKKGSVTMKVLDLGGQER 72
                6677888999**************************************99999999998655555 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.2   0.00041      0.37       3      25 ..      18      40 ..      16     176 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00041
   PduV-EutP  3 killiGkvgsGKttLtqalkgee 25
                +il++G  +sGKttL + ++++e
  EFC36911.1 18 EILMVGLANSGKTTLLNVISDNE 40
                599*************9999854 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1    0.0002      0.18      14      51 ..      19      57 ..       9     152 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.0002
                EEEEESTTSSHHHHHHHHTTSS--.SEEEEEETTCEGGG CS
                xxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxx RF
    ABC_tran 14 vaivGenGaGKStLlkllagllkp.teGeilldgkdlke 51
                + +vG   +GK+tLl++++ ++   t  ++ ++++++k+
  EFC36911.1 19 ILMVGLANSGKTTLLNVISDNEPGdTLPTVGVNMRHVKK 57
                45789999***********98765344455444444444 PP

>> NOG1  Nucleolar GTP-binding protein 1 (NOG1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       7.8     7e+03      37      50 ..       4      17 ..       3      21 .. 0.72
   2 ?    9.0   0.8    0.0013       1.2      39      58 .]     104     128 ..      76     128 .. 0.61

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 7.8
        NOG1 37 Lleeikelfankpv 50
                L+ ++ elf+ k++
  EFC36911.1  4 LFSKLWELFNGKQI 17
                78888888887765 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0013
        NOG1  39 eeikelfan.....kpvivvlnKiD 58 
                 +e+++l++n     kp++vvlnKiD
  EFC36911.1 104 RELHKLLENkglegKPLLVVLNKID 128
                 4455544442222388********9 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0    0.0013       1.1       2      20 ..      19      37 ..      19      57 .. 0.83
   2 ?   -0.1   0.0       1.1   9.4e+02      85     111 ..      70      96 ..      58     108 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0013
      AAA_33  2 vllvGlpGsGKstlaerll 20
                +l+vGl+ sGK+tl+  + 
  EFC36911.1 19 ILMVGLANSGKTTLLNVIS 37
                79************87655 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 1.1
      AAA_33  85 rarflklarrlgvpvrivvvetdeetl 111
                 ++rf++l+ ++   + +vv+ +d + +
  EFC36911.1  70 QERFRNLWLEHTKSCDVVVFVVDGADI 96 
                 689999999999999999999998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       458  (0.0255452); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 1109.94
//
Query:       EFC36912.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.9e-36  125.6   0.0      3e-36  125.0   0.0    1.2  1  DUF676        Putative serine esterase (DUF676)
     0.0013   18.5   0.2      0.003   17.3   0.2    1.5  1  PGAP1         PGAP1-like protein
     0.0066   16.3   0.0     0.0099   15.7   0.0    1.2  1  Palm_thioest  Palmitoyl protein thioesterase
     0.0068   16.3   0.0      0.013   15.4   0.0    1.5  1  Lipase_3      Lipase (class 3)
  ------ inclusion threshold ------
      0.011   15.4   0.1      0.024   14.3   0.1    1.5  1  STAS          STAS domain


Domain annotation for each model (and alignments):
>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  125.0   0.0   8.3e-40     3e-36       6     214 ..      27     254 ..      23     259 .. 0.88

  Alignments for each domain:
  == domain 1  score: 125.0 bits;  conditional E-value: 8.3e-40
      DUF676   6 hLvVlvHGlqgnsaDlelikeqleki...keklpeekieflmsennesktfkgidvlgerlaeevlevvkkkkdk.......nkkiSfvghSlGgliar 94 
                  L +l+HGl+g ++D+++i+++l+++   +++ + e  ++     ne kt +gi+ lg ++++evl++++++k +       + k+S++ghSlGgli r
  EFC36912.1  27 DLYILIHGLHGKQQDFHFIAQKLKELyndDSNKDSEHAIIIDCACNEGKTADGIESLGVNVLKEVLKIIYERKVSsllsngkKLKLSIIGHSLGGLIGR 125
                 689**********************9965455555699999999****************************9999****9989*************** PP

      DUF676  95 aaiaklkekem..........t....lkeaikglepvtfitlasPhLGvlysskslinlglalleklkkslsmeqlgltGrdLflkddkdeknsllykl 179
                 + i +l++ ++          +    +++++ +l p  f+t+++PhLG++        +g     ++++ + + +lg+tG++L+l+d +  ++slly++
  EFC36912.1 126 YFIKLLYDLPNnekshdllpeYskhfVDDIFPHLVPCSFTTISTPHLGSRRPGGG-NYFG--SAYRIAAHTFLSILGKTGKELILNDGNSIEESLLYRM 221
                 *******998888888887762455677888889999************998887.3334..44577888999************************** PP

      DUF676 180 lkdekdlkliealklFkrrvlyanvvndrivplas 214
                   + +d  +++ lk+F  r+l+a+   d++vp+ s
  EFC36912.1 222 --SLPDSDYVKVLKMFPYRTLIASCHLDSTVPFPS 254
                 ..4555689***********************988 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.2   8.3e-07     0.003       8     110 ..      30     129 ..      28     136 .. 0.70

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 8.3e-07
       PGAP1   8 lFvpGnagsykqvrslAseaaeayqelrkllknqnkkeldfftvdfneelsaldGrtlldqaeylndaIkyIlsly...sssekeptsviliGHSmGGi 103
                 ++++G+ g  ++   +A++ +e y +++++ ++++           ne  +a   ++l    + l++++k I +       s+ ++ ++ +iGHS+GG+
  EFC36912.1  30 ILIHGLHGKQQDFHFIAQKLKELYNDDSNKDSEHAI----IIDCACNEGKTADGIESLG--VNVLKEVLKIIYERKvssLLSNGKKLKLSIIGHSLGGL 122
                 79******************9999886665555553....3445666777776556665..666666665544333322225666777889******** PP

       PGAP1 104 varaalt 110
                 + r  ++
  EFC36912.1 123 IGRYFIK 129
                 *998765 PP

>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   2.8e-06    0.0099       3      86 ..      30     130 ..      29     144 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2.8e-06
  Palm_thioest   3 viwhGldsaesn.....mqklaeliekli.....gtyvknveigeseaedrkasffgnlndqveavckk........lelangfhaiGfSQGglflR 81 
                   +++hGl  ++ +      qkl+el++++      ++ +  ++ +e++++d  +s+  n+ ++v +++ +        + ++ +  +iG+S Ggl+ R
    EFC36912.1  30 ILIHGLHGKQ-QdfhfiAQKLKELYNDDSnkdseHAIIIDCACNEGKTADGIESLGVNVLKEVLKIIYErkvssllsNGKKLKLSIIGHSLGGLIGR 125
                   578***3333.34446666666666664343222244444557888889999999999999998866666888888755677899************ PP

  Palm_thioest  82 alier 86 
                    +i+ 
    EFC36912.1 126 YFIKL 130
                   *9975 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   3.6e-06     0.013      45      77 ..      90     122 ..      30     142 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3.6e-06
                 S-HHHHHHHHHHHHHHHTT-EEEEEEEETHHHH CS
    Lipase_3  45 eslreqvlkelkrllekypeysivvtGHSLGga 77 
                 e l+   ++++++ll++ +++++ + GHSLGg 
  EFC36912.1  90 EVLKIIYERKVSSLLSNGKKLKLSIIGHSLGGL 122
                 4455556899*********************95 PP

>> STAS  STAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.1   6.7e-06     0.024      26      88 ..      44     107 ..      13     109 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 6.7e-06
                 HHHHHHHHHHHCCC........-SEEEEEEEEE.....EEE-HHHHHHHHHHHHHHHHTT-EEEEES- CS
        STAS  26 sfkeklkravgeepervekkeslkslildlsav.....sfiDssGvraLkeilkelkrigvevvlvni 88 
                 ++ +klk+ + +++     k+s + +i+d+        + i s Gv +Lke+lk +  ++v+ +l+n 
  EFC36912.1  44 FIAQKLKELYNDDS----NKDSEHAIIIDCACNegktaDGIESLGVNVLKEVLKIIYERKVSSLLSNG 107
                 66777777777777....8999********754444449*************************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       559  (0.0311785); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2525.11
//
Query:       EFC36913.1  [L=585]
Description: poly(adp-ribose) glycohydrolase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-90  303.8   0.0    2.4e-90  303.3   0.0    1.2  1  PARG_cat  Poly (ADP-ribose) glycohydrolase (PARG)


Domain annotation for each model (and alignments):
>> PARG_cat  Poly (ADP-ribose) glycohydrolase (PARG)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  303.3   0.0   1.3e-94   2.4e-90       6     335 ..     157     526 ..     154     528 .. 0.87

  Alignments for each domain:
  == domain 1  score: 303.3 bits;  conditional E-value: 1.3e-94
    PARG_cat   6 sekffeevlpklaklalklpslleke............................lrlLkq....qesesvtlsqeqiaallanaFfclfprqernksee 72 
                 ++kff e+++++ kl+l+ p +l                               l+   q     +s+ v+ls+ ++a++lan+Ffc+fpr  ++++  
  EFC36913.1 157 RSKFF-ETVEFIKKLVLDTPIILGPRaktelynhssqkhstiqenggmlpilgdLN---QlpfqLDSKCVKLSKLECACILANSFFCTFPRIGDTRDGP 251
                 55666.5789999999999999877778999999999999999999*966655533...1443367788**********************88876666 PP

    PARG_cat  73 kklp.sinfdrlfssessseskaeklkcllhYFervt....ekepe.gvvsferkvlsk....kekiedwsksekklskveveseglIedqskgalqvd 161
                 + +  sin+d+l +  +  e++a+kl +++hYFer++    e+ ++ g+v f rk+++     +  +++ +++ +++s+++++ eg+Ied   +al+ d
  EFC36913.1 252 HLFMpSINLDSLIN--NPHEASASKLLMIIHYFERLSergyEEIARmGYVHFIRKIVDPthieSLLLASADEEGSTFSEMQIHPEGSIED-CPQALHAD 347
                 66545********9..999******************8888444446********99986654444555666668899************.******** PP

    PARG_cat 162 FAnkyiGGgvlsrGcvQEeirflinPElivsmLfteklednealvivgaerfssytGYassfrfagdyvdktprdslg....rrkteivaiDAlefkke 256
                 FAn yiGGgvl+ G+vQEeirf+++PE ivs+Lf+e+++dne+++ivg+e+fs ++GYa+s+ + gdy+dk   + +       +++iva+D+ ++++ 
  EFC36913.1 348 FANMYIGGGVLRAGAVQEEIRFVLSPETIVSRLFIERMADNESILIVGSEQFSTHKGYAKSLLYGGDYQDKDYEQLYDgnllSFNSQIVAFDSKYYTRY 446
                 *********************************************************************954444333334469*************** PP

    PARG_cat 257 ekekqykkekilRelnKAyvgFksqekeke.eeekvgiaTGnWGCGaFgGdpeLKaliQllAasqagrelvyytfgdkel 335
                 +  +q++ e+i+Re++KAy++F++ +ke    e + +i+TG+WGCGaF  d+eLK++iQ ++as a ++l+yytfg+ke+
  EFC36913.1 447 NLLEQWQVEHIDREITKAYSAFCHVDKELYdLEIYEKISTGHWGCGAFLCDKELKFIIQFISASIAMKPLHYYTFGEKEI 526
                 ***********************99887662567889****************************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (585 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1165  (0.0649785); expected 358.6 (0.02)
Passed bias filter:                      587  (0.0327403); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.78u 0.32s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 3472.83
//
Query:       EFC36914.1  [L=1029]
Description: DEAD/DEAH box helicase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.5e-69  231.9   0.1    2.6e-68  230.3   0.1    1.8  1  SNF2_N          SNF2 family N-terminal domain
    3.2e-19   69.3   1.0    2.3e-18   66.5   0.0    2.9  3  Helicase_C      Helicase conserved C-terminal domain
  ------ inclusion threshold ------
       0.31   10.6   6.3       0.81    9.2   5.7    1.9  2  Mu-like_Pro     Mu-like prophage I protein
       0.99    8.9   8.0        2.7    7.5   8.0    1.8  1  Exonuc_VII_L    Exonuclease VII, large subunit


Domain annotation for each model (and alignments):
>> SNF2_N  SNF2 family N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  230.3   0.1   5.9e-72   2.6e-68      48     350 .]     302     584 ..     290     584 .. 0.89

  Alignments for each domain:
  == domain 1  score: 230.3 bits;  conditional E-value: 5.9e-72
                 .HHHHHTT--EEE---TTS--HHHHHHHHH...HHTTTS---.......S-EEEE--HHHHHHHHHHHHHH-TTS-EEE--SSHHHH------------ CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N  48 saeakqsvrGGiLaDemGLGKTvqvlalilaqrakeekdkekkrkdtlagptLivvPaslldqWeneierhvsssalrvlvyggqkkmkkkntkvapkl 146
                   e++++  GGiL DemGLGKTvq+ ++++ ++              l +p +i++Pa++++qW++ei++++++ ++ +++ ++++  k + + + +k+
  EFC36914.1 302 MCELNRQGVGGILGDEMGLGKTVQITTFLAGLH-----------FSGLFEPSIIIAPATVMKQWQEEINTWWPELRVVIMHTSQGT--KANFESLIEKV 387
                 5688999***********************222...........245679*************************99777777765..44444555555 PP

                 .-----EEEE-HHHHHHHT......TTS-S-S-SEEEES-GGGT--TTSHHHHHHHH---S-EEEE-S--SSS-HHHHHHHHHHH-TTTT--HHHHHHH CS
                 .xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 147 .ladydvvittYdvlsreaelqkkrsvlkqvewkrvvlDEghtlknstskaaeavskLstsnrwiltGTPiqnsledlygLlkfLreepfgekqtfdkl 244
                      +v+ittY+ l+  +      +vl++++w +++lDEgh+++n ++ ++ a+++++t +r+iltGTPiqn+l++l++L++f  ++++g+  +f ++
  EFC36914.1 388 sSCPNGVLITTYESLRIYQ------DVLTSKKWGYIILDEGHKIRNPDAALTLACKRFETPHRIILTGTPIQNNLKELWSLFDFCYPGKLGTLPVFLTQ 480
                 156799**********888......9************************************************************************* PP

                 THHHHH............HHHHHHHHHHHTT-STTEE---GGGT--S---EEEEEEEEE--HHHHHHHH....................HHHHHH-HHH CS
                 xxxxxx............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 245 lqrpie............aqaekgrsrLlqllqrlmlrrakkdveknlPpkteeiiflklskverksYnrllevlrkkalakllkrseaalkssskske 331
                 ++ pi+            ++a+k++  L++l+++++lrr+kkdv+++lP+k+e++if+kl++++ k+Y               lk++e++ + +   ++
  EFC36914.1 481 FSIPITqggysnatkfqvQTAYKCSCVLRDLIKPYLLRRMKKDVKHQLPEKKENVIFCKLTDKQVKIYD------------EYLKSREVTGTLDG--EH 565
                 *********************************************************************............56666666666554..35 PP

                 -HHHHHHHHHHHHH---XX CS
                 xxxxxxxxxxxxxxxxxxx RF
      SNF2_N 332 kilelllelrqacnhpqlv 350
                  +++ +++lr++cnhp+l+
  EFC36914.1 566 LLFKAITNLRKVCNHPDLI 584
                 59999***********985 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   1.1       1.1   5.2e+03      38      56 ..      81      99 ..      61     190 .. 0.62
   2 ?   -2.2   0.0       1.2   5.3e+03      15      37 ..     530     554 ..     520     565 .. 0.66
   3 !   66.5   0.0   5.2e-22   2.3e-18       5     111 .]     607     713 ..     601     713 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.1
                HTTSTEEEESTTSTHHHHH CS
  Helicase_C 38 kkgikvavlhgelpqnere 56
                k++ ++ +l++++++ e+e
  EFC36914.1 81 KEHSRIDKLNAKIEKYEKE 99
                4455555555554444433 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.2
                 TTSEEEEEESSHHHHHH..HHHHHH CS
  Helicase_C  15 eggkilifvntidrlek..vkllle 37 
                 e+++ +if++ +d+  k   ++l++
  EFC36914.1 530 EKKENVIFCKLTDKQVKiyDEYLKS 554
                 4567799999999443335566633 PP

  == domain 3  score: 66.5 bits;  conditional E-value: 5.2e-22
                 HHHHHHHHTTTTSEEEEEESSHHHHHHHHHHHHHTTSTEEEESTTSTHHHHHHHHHHHH.TTSSS.EEEESGGGTSSSTSTTESEEEESSSSSSHHHHH CS
  Helicase_C   5 allellkleeeggkilifvntidrlekvklllekkgikvavlhgelpqnereeileqfn.kgesd.vLiatdvaerGidipkvnlVinfdlprnvtsyi 101
                 +ll l   +e+++++l+f++++++l+ ++ +l+++++++ +++g++p +er   ++qfn ++++  +L++t+v++ G+++ ++n +i fd+++n+++  
  EFC36914.1 607 KLLSL--WKEQNHRVLLFSQSKKMLDVFEPFLQERDYTYSRMDGDTPVKERSVLINQFNsDDKIFvFLLTTKVGGLGVNLIGANRIILFDPDWNPSTDL 703
                 34444..5899**************99888888889***********************64555579******************************** PP

                 HHHTTSSSTT CS
  Helicase_C 102 qriGRtgRag 111
                 q+  R++R g
  EFC36914.1 704 QALERAWRLG 713
                 ********76 PP

>> Mu-like_Pro  Mu-like prophage I protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   5.7   0.00018      0.81     130     247 ..      50     167 ..      16     170 .. 0.74
   2 ?   -1.7   0.0      0.36   1.6e+03     218     280 ..     951    1013 ..     913    1024 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00018
  Mu-like_Pro 130 aalaaateqeeekekeeekellkkllaaLgleedateeqilaalkalkeekaavaealglka..gaktaeasaevaaLsakavDlakyvpveaaqalq 225
                   ++a +te+ e++ + e ++ ++++ + L+ +e+   ++++a+++++++e +++++  +l++  ++k ++ ++++a+L  k+   +   ++e+  +++
   EFC36914.1  50 GVSAFRTEDIEKNVMDEVNKQIEENQKVLEKKEHSRIDKLNAKIEKYEKELKELNKRSSLSSsdEKKIKSLKKKIATLLDKK--DEMIEELEDRREIR 145
                  33333444444444445559999999******99999**********99998888777666511556677889999992222..2445569******* PP

  Mu-like_Pro 226 aelaalkakiaekeaealiekA 247
                  ++l+ + + ++e+e e+li + 
   EFC36914.1 146 ESLNVIDNDNNESERERLIRTG 167
                  ******************9875 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.36
  Mu-like_Pro  218 veaaqalqaelaalkakiaekeaealiekAlkeGkltp.alkdwaralakkdlaalkaflekap 280 
                   v+++++l++el+ +  k+++k ++++++   k Gk t+ + +++   +  +d+  +k++l+k  
   EFC36914.1  951 VNNVNDLADELKPVY-KSSNKMVDNIVSFFQKRGKATTdEVRKHFSYITGDDVIYFKELLQKIA 1013
                   455555555555543.456677888888888999988867788888888888888888888765 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   8.0   0.00059       2.7     194     258 ..      58     144 ..       6     244 .. 0.57

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00059
  Exonuc_VII_L 194 eleerleralkkqlkkkrerleelkerl.k...ekleekkerlkklkerle..................lleekkerleeleeklea 258
                   ++e+++  +++kq++++++ le+ +++      +k+e+ +++lk+l++r +                  ll++k+e++eele++ e 
    EFC36914.1  58 DIEKNVMDEVNKQIEENQKVLEKKEHSRiDklnAKIEKYEKELKELNKRSSlsssdekkikslkkkiatLLDKKDEMIEELEDRREI 144
                   222222222222222222222222211111122222222222222222222111111111111111113344444455554444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1029 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2979  (0.166155); expected 358.6 (0.02)
Passed bias filter:                      697  (0.0388756); expected 358.6 (0.02)
Passed Vit filter:                       108  (0.00602376); expected 17.9 (0.001)
Passed Fwd filter:                        33  (0.00184059); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.15u 0.36s 00:00:01.50 Elapsed: 00:00:00.55
# Mc/sec: 5675.14
//
Query:       EFC36915.1  [L=361]
Description: ran gtpase binding protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-18   66.0   0.3    8.1e-18   64.9   0.3    1.6  1  Ran_BP1   RanBP1 domain
    0.00027   21.1   1.3    0.00027   21.1   1.3    2.1  2  DUF2076   Uncharacterized protein conserved in bacteria (DUF2
  ------ inclusion threshold ------
      0.029   14.4   2.0      0.079   13.1   2.0    1.7  1  bZIP_1    bZIP transcription factor
      0.072   12.9   4.0       0.14   12.0   4.0    1.4  1  SKA1      Spindle and kinetochore-associated protein 1


Domain annotation for each model (and alignments):
>> Ran_BP1  RanBP1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.9   0.3   1.8e-21   8.1e-18       1     118 [.     227     356 ..     227     360 .. 0.79

  Alignments for each domain:
  == domain 1  score: 64.9 bits;  conditional E-value: 1.8e-21
                 ----SSTTEEEEEEEE.EEEEEEET..TTTEEEEEEEEEEEEEEETTT.TEEEEEEEETTTTEEEEEEEE-TTS-EEESTTES......SEEEEEE..E CS
     Ran_BP1   1 evksgEEdEevlfkqr.aKLfrfda..ekkewkeRGvGdiKilkkkdd.ekvRllmRrdqvlkvcaNhvitkemklkplagsd......rslvwta..a 87 
                 e+ksgEE E v+ + + aKL+r      k++w++RGvG ++++ +kdd ++ R++mR d v+k+++N  i k mk++pl+         +s +  +  a
  EFC36915.1 227 EIKSGEEGEIVVGEFKlAKLYRTVVvdGKSSWQQRGVGSLRLNVRKDDeKNARMVMRTDSVFKLILNCKIIKGMKFTPLQEQSiifpvhKSQLCEQlsA 325
                 89**********876559****765115699************999997889**************************986541111113333333224 PP

                 E-TTSSSEEEEEEEEESSHHHHHHHHHHHHH CS
     Ran_BP1  88 daadeeakleqlaikfkkkeeadefkkkfee 118
                 +  ++e++ +   i+f +k+   +f++k+e 
  EFC36915.1 326 EELAKEPEFVSHLIRFDQKNDRPQFNQKIES 356
                 4455677888999***************996 PP

>> DUF2076  Uncharacterized protein conserved in bacteria (DUF2076)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   1.3   5.9e-08   0.00027      54     141 ..      32     124 ..      30     148 .. 0.57
   2 ?   -3.1   6.5       1.4   6.3e+03      79     130 ..     147     202 ..     135     231 .. 0.57

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 5.9e-08
     DUF2076  54 eaaLkqanariqeLeaqlqqlqqqaqeaqaqpssggFLsglFGggkke....rpqpspqarpaapagqalgqeeqyaaqpgyaq..qqaqpqyg 141
                 ++++k++++r+++Le+q + l++q qe++++ps ggF  + F + k+      p p++  +p+ +++++   ++++  ++++++  ++++p+ +
  EFC36915.1  32 DNIIKELEKRVKDLENQTETLKKQLQEKSSAPSTGGFAFS-FNQPKQTtpvtFPTPAAVTTPVVETKPVTITPTAAVVPQEKKEeeKKPEPKVE 124
                 789**********************************544.55555444666333333333333333333333332222222222223333333 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.4
     DUF2076  79 qeaqaqpssggF..LsglFGggkke........rpqpspqarpaapagqalgqeeqyaaqpg 130
                 ++++ + s ggF  +s+ FGg   e        +      + p + +++  ++e++  +++g
  EFC36915.1 147 SSESGKFSFGGFssFSSPFGGSTGEsqfkfeisS------KPPTWTNQEYKPKESEDGEEDG 202
                 34445555678888999***99999544333321......2222222222222222222222 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   2.0   1.8e-05     0.079      26      51 ..      33      58 ..      30      62 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.8e-05
                HHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1 26 aeieeLerrvkaLekeNksLkselee 51
                  i+eLe+rvk Le++ ++Lk++l+e
  EFC36915.1 33 NIIKELEKRVKDLENQTETLKKQLQE 58
                569*******************9987 PP

>> SKA1  Spindle and kinetochore-associated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   4.0     3e-05      0.14      22     123 ..      32     131 ..      22     139 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3e-05
                 ..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        SKA1  22 kedlskieaevsaleellnklkkelqeeeeaikklkkeieaslkqqeklqhlkenlpshlpkktaassaeeskssspeeeeeteskkekeeeaekakkp 120
                  ++++++e+ v+ le++ + lkk+lqe+++a ++    +  s++q +++  +   +p+ +   + +++ ++ +       +e++++++k+e++ ++kk+
  EFC36915.1  32 DNIIKELEKRVKDLENQTETLKKQLQEKSSAPSTGG--FAFSFNQPKQTTPVTFPTPAAVTTPVVETKPVTITPTAAVVPQEKKEEEKKPEPKVEEKKE 128
                 5789***********************999988888..9999988888888888888888887777776654333332222223333344444444444 PP

                 XX- CS
        SKA1 121 kkr 123
                 +++
  EFC36915.1 129 EEK 131
                 443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (361 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1621  (0.0904122); expected 358.6 (0.02)
Passed bias filter:                      894  (0.0498633); expected 358.6 (0.02)
Passed Vit filter:                       129  (0.00719505); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.69u 0.34s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 2139.61
//
Query:       EFC36916.1  [L=401]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-06   28.2   0.1    1.1e-06   28.2   0.1    2.0  2  SWIM          SWIM zinc finger
    0.00014   22.1  12.3    0.00014   22.1  12.3    2.2  3  zf-RING_2     Ring finger domain
    0.00048   20.0   0.0    0.00094   19.1   0.0    1.5  1  Rho_N         Rho termination factor, N-terminal domain
  ------ inclusion threshold ------
      0.034   13.9   0.6        2.7    7.8   0.0    2.6  2  SAP           SAP domain
      0.084   12.2   2.9       0.13   11.6   1.5    2.0  2  EcKinase      Ecdysteroid kinase
        0.2   11.8  11.6       0.64   10.2  11.6    1.9  1  RINGv         RING-variant domain
       0.67    9.7   3.7       0.48   10.2   0.8    2.2  2  DUF5318       Family of unknown function (DUF5318)
        1.4    8.6  10.8        0.4   10.3   7.3    1.9  2  Zn_ribbon_17  Zinc-ribbon, C4HC2 type
        2.3    8.2  13.9        5.2    7.1  13.9    1.7  1  PHD           PHD-finger


Domain annotation for each model (and alignments):
>> SWIM  SWIM zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   0.1   5.5e-10   1.1e-06       1      39 [.     192     223 ..     192     224 .. 0.91
   2 ?   -3.3   1.0       3.9   7.8e+03      11      21 ..     295     305 ..     290     312 .. 0.71

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 5.5e-10
        SWIM   1 yrVtlddervrlnkatCsCpefqkngipCkHalAvllal 39 
                 y V +++      + +C Cp+ + ng +CkH+l vll++
  EFC36916.1 192 YDVVIGE------EPSCNCPDAE-NGNLCKHVLFVLLKV 223
                 7888885......9*********.************975 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.9
        SWIM  11 rlnkatCsCpe 21 
                 + +  +C C+ 
  EFC36916.1 295 QKEAGYCHCCG 305
                 55677898884 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       6.5   1.3e+04      38      42 ..     149     153 ..     134     153 .. 0.62
   2 ?   -3.3   0.3       6.1   1.2e+04      19      24 ..     212     216 ..     200     218 .. 0.60
   3 !   22.1  12.3   7.1e-08   0.00014       2      44 .]     281     329 ..     280     329 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 6.5
   zf-RING_2  38 stCPl 42 
                 s+CP+
  EFC36916.1 149 SSCPI 153
                 23875 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 6.1
   zf-RING_2  19 lpCgHv 24 
                 l C+Hv
  EFC36916.1 212 L-CKHV 216
                 3.7776 PP

  == domain 3  score: 22.1 bits;  conditional E-value: 7.1e-08
   zf-RING_2   2 eCpICleelssads...vlllpCgHv.fhreClerwlrssst..CPlCr 44 
                 +CpIC++ +s+ d+   +  ++C+ v  h +Cl+ w   +++  CP+C+
  EFC36916.1 281 NCPICCDGFSQLDEqkeAGYCHCCGVnVHADCLKAWKGFNKEypCPICK 329
                 7*****888554443344355566665*********88888888****7 PP

>> Rho_N  Rho termination factor, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   4.7e-07   0.00094       1      36 [.      26      62 ..      26      63 .. 0.93

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 4.7e-07
                HHHHS-HHHHHHHHHHTT-.TTGGGS-HHHHHHHHHH CS
       Rho_N  1 eLkektlseLraiAkelgi.enysrlRKqdLIfaIlk 36
                +L ++t+ +L++  k+lgi  + s lRK +LI++I++
  EFC36916.1 26 DLWALTVDQLKQHMKDLGIyHGCSHLRKEELIEKIKE 62
                56789**************99**************86 PP

>> SAP  SAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0    0.0014       2.7       4      18 ..      30      44 ..      29      44 .. 0.93
   2 ?    3.6   0.2     0.028        56      23      34 ..      52      63 ..      51      64 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0014
                --HHHHHHHHHHTT- CS
         SAP  4 ltVaeLKeeLkkrGL 18
                ltV++LK+ +k +G+
  EFC36916.1 30 LTVDQLKQHMKDLGI 44
                9***********996 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.028
                -HHHHHHHHHHH CS
         SAP 23 kKaeLieRLkey 34
                +K+eLie +ke+
  EFC36916.1 52 RKEELIEKIKEF 63
                6*********98 PP

>> EcKinase  Ecdysteroid kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   1.5   6.5e-05      0.13     111     161 ..      29      78 ..      22     133 .. 0.83
   2 ?   -1.5   0.1      0.61   1.2e+03     134     165 ..     119     149 ..     110     187 .. 0.55

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.5e-05
    EcKinase 111 gldlehlklvlkkLAkfHAaSlalkeekpevfkelkkglleedyvssalke 161
                  l++++lk  +k L+ +H++S   kee  e++ke++ +l+ee++ +++ ++
  EFC36916.1  29 ALTVDQLKQHMKDLGIYHGCSHLRKEELIEKIKEFN-HLVEEHHHDHHGEK 78 
                 58899******************************9.78888777775333 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.61
    EcKinase 134 lkeekpevfkelkkglleedyvssalkeafee 165
                   +e+p++++  ++++++++  +++ k+ f +
  EFC36916.1 119 K-KEEPAEVAATTHHHISSHKSKEHRKRRFVS 149
                 3.355777777777777777766654433332 PP

>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2  11.6   0.00032      0.64       1      48 []     282     328 ..     282     328 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00032
                 ETTTTEE-SSSS..--B-SS--STCCCSB-HHHHHHHHHHTCT-SB-TTT CS
       RINGv   1 CriCleeeeese..plispCkCrGslklvHesClekWldekeantqCeiC 48 
                 C iC ++ ++ +  +    C+C G    vH +Cl+ W    +++  C iC
  EFC36916.1 282 CPICCDGFSQLDeqKEAGYCHCCG--VNVHADCLKAWKGF-NKEYPCPIC 328
                 8888887665443456779*****..78**********99.999****** PP

>> DUF5318  Family of unknown function (DUF5318)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       1.1   2.1e+03     107     126 ..      62      81 ..      53      85 .. 0.76
   2 ?   10.2   0.8   0.00024      0.48      30     110 ..     302     383 ..     291     399 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.1
     DUF5318 107 swnhlvesyvlGkeeeakek 126
                 ++nhlve++   +++e++++
  EFC36916.1  62 EFNHLVEEHHHDHHGEKRKH 81 
                 689***99988777766655 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00024
     DUF5318  30 evcdaspyllraakfhGeptdvacPvcrkenltlvsyvyGdelkqa.aGsartaeelerlaatleefsvyvvevcrscswnh 110
                 + c  +++      + G +++  cP+c+  ++ +   v   + +++   +a+ +e   +l++ + e++  + e  +s  wn 
  EFC36916.1 302 HCCGVNVHADCLKAWKGFNKEYPCPICKASKMGEGGGVAAASHHHSnNNQAKMNEGYLNLSEFQPEITTTEREYVHSSRWNQ 383
                 566666666666778999****************9999988777762579999999************************95 PP

>> Zn_ribbon_17  Zinc-ribbon, C4HC2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       3.9   7.9e+03      23      28 ..     212     217 ..     211     218 .. 0.81
   2 ?   10.3   7.3    0.0002       0.4       4      46 ..     279     326 ..     276     336 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.9
  Zn_ribbon_17  23 vCeHvl 28 
                    C+Hvl
    EFC36916.1 212 LCKHVL 217
                   6***96 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.0002
  Zn_ribbon_17   4 lksCayCe.....lavkgrvvlcgvCeHvlHasCarew..fenddlaeCp 46 
                   + +C +C+     l  ++   +c  C+  +Ha+C+++w  f+++    Cp
    EFC36916.1 279 TSNCPICCdgfsqLDEQKEAGYCHCCGVNVHADCLKAWkgFNKEY--PCP 326
                   667888854444488899********************6666665..666 PP

>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  13.9    0.0026       5.2       2      51 ..     282     330 ..     281     331 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0026
                 BTTTTS...TTSTTSCEEEETTTSCEEETTTSSSTHSHHSHHSSTBSSTTTHT CS
         PHD   2 CavCkk...ksdeeeelvqCdgCkrwfHqkClkppleseekpegewlCekCke 51 
                 C +C +   + de++e  +C+ C+  +H +Clk  +      ++e+ C+ Ck 
  EFC36916.1 282 CPICCDgfsQLDEQKEAGYCHCCGVNVHADCLKAWKG----FNKEYPCPICKA 330
                 888877799999*********************9966....44479*****86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (401 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1603  (0.0894082); expected 358.6 (0.02)
Passed bias filter:                      505  (0.0281667); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 2239.96
//
Query:       EFC36917.1  [L=319]
Description: hypothetical protein NAEGRDRAFT_82095 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       484  (0.0269954); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1993.02
//
Query:       EFC36918.1  [L=483]
Description: hypothetical protein NAEGRDRAFT_54100 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.7e-05   23.9   0.8    0.00024   20.9   0.3    2.9  2  F-box       F-box domain
     0.0003   21.1  43.0       0.32   11.5   0.4    8.1  7  LRR_4       Leucine Rich repeats (2 copies)
     0.0049   16.7   0.5      0.014   15.2   0.5    1.8  1  F-box-like  F-box-like
  ------ inclusion threshold ------
        1.7    9.5  14.2         33    5.6   0.2    6.5  5  LRR_1       Leucine Rich Repeat
          3    8.1  15.2        6.8    7.0   0.0    5.6  6  LRR_6       Leucine Rich repeat
        5.6    6.7  11.3        6.7    6.5   5.4    3.3  2  DUF1647     Protein of unknown function (DUF1647)


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.3   7.9e-08   0.00024       5      45 ..      67     108 ..      64     110 .. 0.92
   2 ?   -1.7   0.0      0.96   2.9e+03      17      41 ..     285     309 ..     283     312 .. 0.77

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 7.9e-08
                 HS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHHHHH CS
       F-box   5 rLPsevlrhILerLplsd.llalrrVSkgwrilidsdrlwck 45 
                 +L s+ l hI ++L+l+  +  + +V+k+w++ ++++++  k
  EFC36918.1  67 QLNSDNLFHIYQFLDLKNlVHCCQLVCKSWKQTLNRVNFTVK 108
                 69999******************************9998765 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.96
                 TS-HHHHHHHCTT-HHHHHHHTTHH CS
       F-box  17 rLplsdllalrrVSkgwrilidsdr 41 
                 +L + d+  ++   + + +l+ s++
  EFC36918.1 285 NLTFLDIAHCSISNRELGDLLVSPN 309
                 7999999999998888777776665 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       4.4   1.3e+04      17      25 ..      78      85 ..      68      87 .. 0.55
   2 !   10.1   0.5   0.00029      0.86      13      33 ..     141     161 ..     126     167 .. 0.81
   3 !    6.1  11.9    0.0052        15       1      36 [.     151     190 ..     151     248 .. 0.86
   4 !    5.8   0.2    0.0065        19       3      40 ..     261     297 ..     251     304 .. 0.76
   5 !    7.6   0.4    0.0017       5.2       2      32 ..     285     322 ..     285     334 .. 0.70
   6 !   11.5   0.4   0.00011      0.32       2      30 ..     339     366 ..     338     372 .. 0.92
   7 !    5.9   2.0    0.0063        19      10      32 ..     376     397 ..     375     418 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 4.4
                S-HHH-TT- CS
       LRR_4 17 plleklpnL 25
                ++l  l+nL
  EFC36918.1 78 QFLD-LKNL 85
                4444.5555 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00029
                 --E-S-HHH-TT--EEE-.-S CS
       LRR_4  13 ltdiplleklpnLkeLdLsgN 33 
                  +++++++kl nLk+LdL+  
  EFC36918.1 141 FKSLSSCKKLQNLKTLDLNYS 161
                 57899999**********544 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0052
                 SS--EEE--SS---E-S-..HH..H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..klpnLkeLdLsgNnli 36 
                 +nL++LdL+  +l +     l+  ++pnL+eL L++ ++ 
  EFC36918.1 151 QNLKTLDLNYSRLGKTAVkyLAkcQMPNLTELKLNNASNF 190
                 69*******7699975556755767*********443333 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0065
                 --EEE--SS---E-S-.HH..H-TT--EEE-.-S-----GG CS
       LRR_4   3 LevLdLsnNqltdipl.le..klpnLkeLdLsgNnlitdld 40 
                 Le L ++  +lt  p  l   ++ nL+ Ld+ ++    +++
  EFC36918.1 261 LERLEIRRFNLTNYPKlLTdgSFMNLTFLDIAHC----SIS 297
                 6777777557888888533746999999999888....554 PP

  == domain 5  score: 7.6 bits;  conditional E-value: 0.0017
                 S--EEE--SS---E-S-...HH..H-TT--EEE..-.- CS
       LRR_4   2 nLevLdLsnNqltdipl...le..klpnLkeLd..Lsg 32 
                 nL++Ld++++ ++  +l   l   +lp+L +L+  +s+
  EFC36918.1 285 NLTFLDIAHCSISNRELgdlLVspNLPKLATLHasCSS 322
                 8********9999555555422667****999966644 PP

  == domain 6  score: 11.5 bits;  conditional E-value: 0.00011
                 S--EEE--SS---E-S-HHH.-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipllek.lpnLkeLdL 30 
                 +L+ L++sn  + ++p+l++ ++nL +L++
  EFC36918.1 339 SLTDLNFSN--IASFPSLANyCTNLLKLTI 366
                 79*******..********99****99986 PP

  == domain 7  score: 5.9 bits;  conditional E-value: 0.0063
                 SS---.E-S-HHH-TT--EEE-.- CS
       LRR_4  10 nNqlt.diplleklpnLkeLdLsg 32 
                 +N l   i++++ l nLk Ld+ +
  EFC36918.1 376 SNALIdLISSPN-LSNLKRLDI-S 397
                 565551455577.********9.4 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.5   4.8e-06     0.014       9      34 ..      73      99 ..      70     103 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 4.8e-06
  F-box-like  9 LlqIFsyLppsdLlr.lalVCrrWrrv 34
                L +I ++L+++ L+  + lVC++W++ 
  EFC36918.1 73 LFHIYQFLDLKNLVHcCQLVCKSWKQT 99
                889************559******975 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.019        56       1      12 [.     152     163 ..     152     174 .. 0.85
   2 ?   -0.6   0.2       1.2   3.6e+03       1      12 [.     178     189 ..     178     215 .. 0.72
   3 ?    0.7   0.5      0.42   1.3e+03       1      12 [.     233     250 ..     233     270 .. 0.63
   4 ?    5.6   0.2     0.011        33       1      15 [.     285     299 ..     285     314 .. 0.77
   5 ?    1.9   0.0      0.18   5.5e+02       1       8 [.     390     397 ..     390     418 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.019
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++LdL++ +l
  EFC36918.1 152 NLKTLDLNYSRL 163
                 8*******9988 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.2
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L L+n ++
  EFC36918.1 178 NLTELKLNNASN 189
                 899999988776 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.42
       LRR_1   1 nLrhLdL......snnpl 12 
                 nL hL+L      ++n +
  EFC36918.1 233 NLSHLNLkslkmeTGNYG 250
                 788888866666755543 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL+ Ld+ ++++++ 
  EFC36918.1 285 NLTFLDIAHCSISNR 299
                 8**********8433 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.18
       LRR_1   1 nLrhLdLs 8  
                 nL++Ld+s
  EFC36918.1 390 NLKRLDIS 397
                 8******5 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0    0.0023       6.8       3      24 .]     151     172 ..     149     172 .. 0.87
   2 ?   -1.7   0.1       1.5   4.4e+03       3      11 ..     177     185 ..     175     186 .. 0.81
   3 ?   -1.4   0.2       1.1   3.4e+03       4      12 ..     233     241 ..     230     245 .. 0.73
   4 ?    5.7   0.1    0.0062        19       3      17 ..     284     298 ..     284     299 .. 0.90
   5 ?   -2.4   0.1       2.3   6.9e+03       3      11 ..     338     346 ..     338     347 .. 0.83
   6 ?    2.3   0.2     0.075   2.2e+02       2      12 ..     388     398 ..     387     398 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0023
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L++LdL++  +g   ++ La
  EFC36918.1 151 QNLKTLDLNYSRLGKTAVKYLA 172
                 89**********9999888876 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.5
       LRR_6   3 thLteLdLs 11 
                 ++LteL L+
  EFC36918.1 177 PNLTELKLN 185
                 79***9885 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 1.1
       LRR_6   4 hLteLdLsg 12 
                 +L +L+L++
  EFC36918.1 233 NLSHLNLKS 241
                 678888876 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.0062
       LRR_6   3 thLteLdLsgNdIgD 17 
                 ++Lt Ld++++ I++
  EFC36918.1 284 MNLTFLDIAHCSISN 298
                 58**********986 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 2.3
       LRR_6   3 thLteLdLs 11 
                 ++Lt L+ s
  EFC36918.1 338 SSLTDLNFS 346
                 58999*988 PP

  == domain 6  score: 2.3 bits;  conditional E-value: 0.075
       LRR_6   2 nthLteLdLsg 12 
                  ++L+ Ld+s+
  EFC36918.1 388 LSNLKRLDISC 398
                 589******97 PP

>> DUF1647  Protein of unknown function (DUF1647)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.3      0.59   1.8e+03      44      83 ..      15      56 ..       2      78 .. 0.72
   2 ?    6.5   5.4    0.0022       6.7      95     128 ..     249     279 ..      89     291 .. 0.65

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.59
     DUF1647 44 eeeeklvdlselikneedvvFv..satsddhlkeakksiksi 83
                + +++l++l + +k  ++  Fv  s + d+++++ ++ +k +
  EFC36918.1 15 SVNSQLISLASKVKLVDNRYFVnnSGMIDEFIENIHEFLKQV 56
                446677788887777777777744566777887777777665 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0022
     DUF1647  95 ysldlseeeieklkkdknlevrkFntskYPeyvk 128
                 y+ldl  +  ++    ++le+r+Fn ++YP+  +
  EFC36918.1 249 YGLDLCLKDKND---LERLEIRRFNLTNYPKLLT 279
                 444444443333...3589***********9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       870  (0.0485247); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.65u 0.27s 00:00:00.92 Elapsed: 00:00:00.47
# Mc/sec: 3100.82
//
Query:       EFC36919.1  [L=1100]
Description: RGS domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    6.2e-08   32.9  13.7    3.9e-07   30.3   0.5    3.1  4  RGS        Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.066   13.5   0.1       0.16   12.3   0.1    1.6  1  NAAA-beta  beta subunit of N-acylethanolamine-hydrolyzing aci


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       1.1     1e+04      43      66 ..      88     111 ..      71     127 .. 0.68
   2 !   11.7   0.2   2.6e-05      0.23       1      53 [.     203     253 ..     203     263 .. 0.84
   3 !   30.3   0.5   4.4e-11   3.9e-07      49     114 ..     585     662 ..     571     666 .. 0.92
   4 ?   -4.4   0.5         2   1.8e+04      68      81 ..     989    1002 ..     969    1012 .. 0.45

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.1
                 HHHHHHHHHHHHHHHTSTTSTTSS CS
         RGS  43 qeelkkkakeIyneylapsspkel 66 
                 +  +++ a +++n++  +ss  + 
  EFC36919.1  88 KTHTSSFASKLFNRFRTNSSHDKN 111
                 444555577777777776666554 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 2.6e-05
                 -HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHH CS
         RGS   1 sleslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeI 53 
                 s++ ++ d +  ++F  +le+e++ e l+F   v+e++ +    +++k++k+I
  EFC36919.1 203 SFQGIFTDRTMFRAFYRYLETEHNTEPLEFITRVNELEFT--YYKMMKMVKDI 253
                 688999******************************9987..44555555544 PP

  == domain 3  score: 30.3 bits;  conditional E-value: 4.4e-11
                 HHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS............STTTTTTHHHHHHHHHHHHHHHHHHHHTSHH CS
         RGS  49 kakeIyneylapsspkelnidkklreelekrleke............qpsrklfeeaqeevfellekdsypkFlksel 114
                  a +I++ +++++s+ke+ni+++ + +    ++++            qp + lf  ++++v+  le+ds+p+F++s++
  EFC36919.1 585 LAIQIMKDFIEEDSKKEINISSRDKRTFVGLFQESkqyqefdewllpQPPHLLFRTMKNSVMYELENDSFPRFVRSDV 662
                 5889*****************99999999999988999**************************************97 PP

  == domain 4  score: -4.4 bits;  conditional E-value: 2
                  S-HHHHHHHHHHHC CS
         RGS   68 idkklreelekrle 81  
                   +kk  ++l+k+le
  EFC36919.1  989 EKKKKEKKLKKQLE 1002
                  22222223333333 PP

>> NAAA-beta  beta subunit of N-acylethanolamine-hydrolyzing acid amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   1.7e-05      0.16      14      47 ..     568     601 ..     566     604 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.7e-05
   NAAA-beta  14 PeeRWtqvakdykpelksliqvlkdllkslvpgk 47 
                 P+  ++qv+k y+++++ +iq++kd++++  +++
  EFC36919.1 568 PRSKYDQVLKVYRKQIMLAIQIMKDFIEEDSKKE 601
                 8899***********************9887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1100 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2377  (0.132579); expected 358.6 (0.02)
Passed bias filter:                      505  (0.0281667); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.25u 0.36s 00:00:01.61 Elapsed: 00:00:00.56
# Mc/sec: 5900.67
//
Query:       EFC36920.1  [L=157]
Description: hypothetical protein NAEGRDRAFT_82098 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.083   13.3   0.1       0.13   12.6   0.1    1.4  1  HMw1_D2   HMW1 domain 2


Domain annotation for each model (and alignments):
>> HMw1_D2  HMW1 domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   7.2e-06      0.13      27      72 ..       8      52 ..       1      65 [. 0.87

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 7.2e-06
     HMw1_D2 27 eaafskraailqwlpeklaqlenldnlPsaishdvymhcsydiaen 72
                ++a ++r+  l+  p + +q ++ +++P++i+ d y   sy   +n
  EFC36920.1  8 QSATENRSSNLKNNPTRSDQ-QSTHKIPNSILSDAYNNTSYSNVQN 52
                67889999999999999998.6789****************98887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (157 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1322  (0.0737353); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 961.64
//
Query:       EFC36921.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-37  130.1   0.0    2.5e-36  125.7   0.0    2.3  1  Acetyltransf_2  N-acetyltransferase


Domain annotation for each model (and alignments):
>> Acetyltransf_2  N-acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  125.7   0.0   1.4e-40   2.5e-36       5     233 ..      36     325 ..      33     328 .. 0.89

  Alignments for each domain:
  == domain 1  score: 125.7 bits;  conditional E-value: 1.4e-40
                     HHHHHHHHHHHS-EE-HHHHTT..............-----SHHHHHHHHTTST--B-HHHHHHHHHHHHHHTT-EEEEEEEEEETTG....GSS CS
  Acetyltransf_2   5 LrellqahlraiPFENldvllg..............eeieldlealfdklVkkkRGGyCyelNgLlarvLkelGFevtllagrvvvka....eea 81 
                     L+++  +h+  iPFENl+ l                 +++ld +++f klV k+RGG+C+e+N Llar+L+e GF+vt+++ + +++      ++
      EFC36921.1  36 LHTISWNHAIHIPFENLATLYPemrmfssdsslpdsIKVSLDPNDIFTKLVLKSRGGFCFEQNLLLARALREFGFSVTTVGVKLLNRFvapeLDS 130
                     899999************998888899999999988899***************************************98887766541111333 PP

                     S..SSSCEEEEEEEEETTE.EEEE-SSSSCG..-SS-EESSTTCEEEESSE.EEEEEEETTCEEEEEEEETTEEE.................... CS
  Acetyltransf_2  82 a..stertHllllVtidge.tylvDvGFGgs.tltaplelesgkdqqtthg.ifrlveeeenewvlekkkreewv.................... 151
                        ++  tH++llV+ ++  +ylvD G G   ++ +pl l++g +++++ g +frlv  +  ++++ k ++++w                     
      EFC36921.1 131 GlpLSCTTHMALLVDCQDGnRYLVDNGLGWGgQPRSPLLLSNGCEKSENTGeVFRLVLGK--IFTSTKLNHDKWGcyrfktganinhqdvneeng 223
                     2246678*******986655*********999***********999988888****7644..69**********99******************* PP

                     ....................EEEEEEEE.EB-HHHHHHHHHHHHHSTT-HHHCS-EEEEEETTEEEEEETTEEEEEETTSEEEEEEE-SHHHHHH CS
  Acetyltransf_2 152 ....................klYsftle.prqiedfeeandylstspdsvftkkllcslatpdgrltLvgrtlterekdgaleeiklltdeelee 225
                                         ++ +f+     +  d e + +y  t p+   tk +l++l+t++gr+ +v+r++t r k g+++e++++++eel +
      EFC36921.1 224 qlvqkkwflqyknkpesewwDIMHFEEDnIMSLLDAELGAWYATTNPNHGQTKIVLVALMTSEGRYSIVDRKFTIR-KLGNVTERTIESEEELWD 317
                     ******************9977777765156789******************************************.8888************** PP

                     HHHHTT-- CS
  Acetyltransf_2 226 vlkekFgi 233
                     +l+++Fgi
      EFC36921.1 318 ILEKYFGI 325
                     *******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       489  (0.0272742); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1935.89
//
Query:       EFC36922.1  [L=1036]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.4e-14   52.0   5.0    4.4e-06   27.0   0.8    2.7  2  RGS            Regulator of G protein signaling domain
     0.0076   16.2   3.9       0.21   11.6   0.2    3.5  3  SafA           Two-component-system connector protein


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.8   4.9e-10   4.4e-06       3      93 ..     446     556 ..     444     566 .. 0.86
   2 !   26.3   0.2     8e-10   7.1e-06       5      70 ..     904     969 ..     900    1017 .. 0.73

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 4.9e-10
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-H..HHHHHHHHHHCSS................ CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidk..klreelekrleke................ 83 
                 e +l++ +   l+ eF ++ ++ e +  + ++e+f+k  +++  kk a++I+++yl+++s+ eln+++  k  ee+e+ l+k+                
  EFC36922.1 446 ETVLKNRKTFALLLEFSRRCYCPEDVLAFRDIEKFRKI-SKKHKKKVATKILKTYLKSGSSLELNMSNlsKKYEEIESILQKAtnpslipntlfddirv 543
                 7899**********************************.99999999*****************99862255679999999988888877777777777 PP

                 ...STTTTTTHHH CS
         RGS  84 ...qpsrklfeea 93 
                    +++ ++fe++
  EFC36922.1 544 lclNNMVDVFERL 556
                 7777777777776 PP

  == domain 2  score: 26.3 bits;  conditional E-value: 8e-10
                 HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-H CS
         RGS   5 lledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidk 70 
                  l++ +   l+ +F  +++++e +  + ++e+f+k+ ++++ k  a +I+++yl+++sp elni +
  EFC36922.1 904 FLKNRKTFALLLDFATRSYCNEDVLAYRDIENFRKSPKRKNKKLVAMKILKTYLKEGSPLELNIAN 969
                 68899999****************************777777777*****************9964 PP

>> SafA  Two-component-system connector protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1      0.31   2.8e+03      17      37 ..      12      32 ..       3      44 .. 0.70
   2 !   11.6   0.2   2.3e-05      0.21      15      50 ..     273     308 ..     270     311 .. 0.94
   3 !    3.5   0.1    0.0077        69      16      50 ..     738     772 ..     728     786 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.31
        SafA 17 keimsvivvvllltltliaif 37
                  i+s++ + + l l  +ai 
  EFC36922.1 12 TPIVSAVFLFVYLCLVTLAII 32
                567888777666666666664 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 2.3e-05
        SafA  15 nykeimsvivvvllltltliaifsaidqlsisemGr 50 
                  yk i s  +v ++l l + aif   d l +s+ G+
  EFC36922.1 273 SYKLIASSYIVAFILHLIIWAIFGGADELVVSNGGK 308
                 59******************************9885 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.0077
        SafA  16 ykeimsvivvvllltltliaifsaidqlsisemGr 50 
                 yk i  +  + +++ l++ a++  id ls s+ G+
  EFC36922.1 738 YKFIAITYTISFIIHLSIWALLGGIDELSYSNSGK 772
                 888888888899999****************9995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1036 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1720  (0.095934); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.85u 0.32s 00:00:01.17 Elapsed: 00:00:00.50
# Mc/sec: 6203.10
//
Query:       EFC36923.1  [L=386]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (386 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       909  (0.0507); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2239.68
//
Query:       EFC36924.1  [L=920]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-06   28.2   0.9    0.00013   21.8   0.9    2.8  1  DDE_3     DDE superfamily endonuclease


Domain annotation for each model (and alignments):
>> DDE_3  DDE superfamily endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.9   7.1e-09   0.00013      61     135 ..     442     514 ..     361     523 .. 0.59

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 7.1e-09
       DDE_3  61 aedfaeflerlletalqakkivlilDnasiHkseslrelveeeadrlellylPpySPelNpiEi.vwsklkrellk 135
                  e++++++e++  +  ++ + +l++Dn+s Hk++s+++++++  ++   + lP   +++ p  + ++++ krel +
  EFC36924.1 442 IEHIEQWVEKVYIPNSKE-GDILLWDNLSHHKCKSVQKILKQ--HNRINILLPVGGHHQSPLDNmCFRYAKRELAD 514
                 234455555555555555.***********************..88888889999999999765378888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (920 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1462  (0.0815439); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.81u 0.37s 00:00:01.18 Elapsed: 00:00:00.53
# Mc/sec: 5231.33
//
Query:       EFC36925.1  [L=267]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1007  (0.056166); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1645.04
//
Query:       EFC36926.1  [L=469]
Description: hypothetical protein NAEGRDRAFT_82042 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (469 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1931  (0.107703); expected 358.6 (0.02)
Passed bias filter:                      215  (0.0119917); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.97u 0.40s 00:00:01.37 Elapsed: 00:00:00.56
# Mc/sec: 2531.57
//
Query:       EFC36927.1  [L=328]
Description: hypothetical protein NAEGRDRAFT_82043 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2952  (0.164649); expected 358.6 (0.02)
Passed bias filter:                      727  (0.0405488); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.56
# Mc/sec: 1770.42
//
Query:       EFC36928.1  [L=228]
Description: hypothetical protein NAEGRDRAFT_82044 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.02   15.3   1.5       0.02   15.3   0.3    1.6  2  DUF4140       N-terminal domain of unknown function (DUF4140)
       0.42   10.3  13.8      0.094   12.4  10.3    1.7  2  Med4          Vitamin-D-receptor interacting Mediator subunit
        5.8    6.4   9.2        6.9    6.1   9.2    1.3  1  Exonuc_VII_L  Exonuclease VII, large subunit
        6.4    6.0   7.1          8    5.7   7.1    1.2  1  DUF4407       Domain of unknown function (DUF4407)


Domain annotation for each model (and alignments):
>> DUF4140  N-terminal domain of unknown function (DUF4140)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.3   0.3   4.5e-06      0.02      23      96 ..      53     134 ..      42     136 .. 0.71
   2 ?   -3.0   0.0       2.3     1e+04      48      55 ..     199     206 ..     180     224 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 4.5e-06
     DUF4140  23 nevtiegLpptldedSlrVe.......gagaatildvqvervpnreaeee..elkalraeleeledelaaledelaaaearla 96 
                  +v i  +++++ e+S+ V+        +++++  d+ ++++   +++++   +++lr+e ++le e ++l+++l ++e++ +
  EFC36928.1  53 KQVFIPTVSSNVVENSIIVKkfpfpylKRKSIR-VDLVLKQQKLAQQKKNssPIQKLRNEKKQLELENSKLKSKLLNLENQFN 134
                 68899999************7655442223333.3333333333333333645**********************99999876 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.3
     DUF4140  48 tildvqve 55 
                   l+++ +
  EFC36928.1 199 EQLSIKPK 206
                 23333333 PP

>> Med4  Vitamin-D-receptor interacting Mediator subunit 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       1.1     5e+03      50      68 ..      26      44 ..      22      55 .. 0.69
   2 ?   12.4  10.3   2.1e-05     0.094      20      72 ..      94     146 ..      87     210 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.1
        Med4 50 ksLkeyekeLkavpdqens 68
                ksL+ +ek+L++ p ++++
  EFC36928.1 26 KSLNVIEKKLSKNPLDNFQ 44
                6788888888888855554 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 2.1e-05
        Med4  20 eleehqknearilqLraeveslDekikeivksLkeyekeLkavpdqenskldt 72 
                 +l +++kn+  i++Lr+e ++l+ + +++ ++L ++e++ +++++q+ +k+ t
  EFC36928.1  94 KLAQQKKNSSPIQKLRNEKKQLELENSKLKSKLLNLENQFNQLINQKSKKMVT 146
                 799*****************************************777776643 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   9.2    0.0015       6.9     161     241 ..      92     190 ..      13     227 .. 0.62

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0015
  Exonuc_VII_L 161 krlleekkqrleklasrlkspeellerkrqrldeleerleralkkqlkkkrerleelkerlk.........ekleekkerl...kklkerle..... 240
                   +++l ++k + ++  ++l++ +++le ++++l++   +le++ ++ +++k++++ ++k++++         +k+ + ++r+          +     
    EFC36928.1  92 QQKLAQQK-KNSSPIQKLRNEKKQLELENSKLKSKLLNLENQFNQLINQKSKKMVTFKQECEctkchmsinSKYMKYHKRIcgnV------Klnril 181
                   22233333.3333346778889999999999999999999999999999999999999877556655444422222222222221......122211 PP

  Exonuc_VII_L 241 ........l 241
                           +
    EFC36928.1 182 nendlkslQ 190
                   122222221 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   7.1    0.0018         8     109     178 ..      87     154 ..      81     226 .. 0.59

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0018
     DUF4407 109 daelaeeqqeeakelkeqlaaaltaelaeleaqiaalqaeidaaearldalraeaqkeldgtkgtgttgv 178
                 d +l++++ +++k++++ ++ +l++e ++le ++++l++++ ++e+++++l ++  k++  t++++++++
  EFC36928.1  87 DLVLKQQKLAQQKKNSSPIQ-KLRNEKKQLELENSKLKSKLLNLENQFNQLINQKSKKMV-TFKQECECT 154
                 44566666777777655555.588888888888888888888888888888877776655.344444442 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2678  (0.149367); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1350.90
//
Query:       EFC36929.1  [L=230]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-20   71.6   0.7    0.00042   20.2   0.0    5.8  6  LRR_6         Leucine Rich repeat
      1e-13   51.2   0.1    8.8e-05   22.8   0.0    4.2  4  LRR_4         Leucine Rich repeats (2 copies)
    6.9e-12   45.0   0.0    1.1e-06   28.3   0.0    2.9  3  LRR_8         Leucine rich repeat
    8.9e-05   22.5   0.0         37    5.4   0.0    5.9  7  LRR_1         Leucine Rich Repeat
  ------ inclusion threshold ------
      0.026   14.0   0.0       0.15   11.6   0.0    2.1  2  LRR_9         Leucine-rich repeat
      0.032   13.6   0.5        2.2    7.6   0.0    2.2  2  DUF1340       Protein of unknown function (DUF1340)
       0.11   12.6   0.1       0.22   11.6   0.1    1.5  1  Dynein_heavy  Dynein heavy chain region D6 P-loop domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.6e-07   0.00042       5      24 .]     105     124 ..     102     124 .. 0.91
   2 !    6.7   0.0    0.0032       8.3       5      23 ..     129     147 ..     125     148 .. 0.88
   3 !   14.0   0.0   1.6e-05      0.04       5      23 ..     153     171 ..     150     172 .. 0.91
   4 !    6.7   0.0    0.0035       8.9       6      24 .]     178     196 ..     175     196 .. 0.80
   5 !   17.0   0.0   1.6e-06    0.0042       5      22 ..     201     218 ..     198     219 .. 0.91
   6 ?   -2.0   0.0       2.1   5.5e+03       5      10 ..     225     230 .]     223     230 .] 0.84

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.6e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+ gN+IgDeG++ ++
  EFC36929.1 105 LTLLDIGGNQIGDEGIKPIS 124
                 899*************9986 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0032
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L +  N+Ig +Ga+ +
  EFC36929.1 129 LTSLYVYNNQIGVAGAKYI 147
                 99999***********977 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 1.6e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L +sgN IgD Ga+ +
  EFC36929.1 153 LTSLTISGNYIGDTGAKFI 171
                 9***************987 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0035
       LRR_6   6 teLdLsgNdIgDeGaeaLa 24 
                 t+L+  +N+Ig eGa++++
  EFC36929.1 178 TSLNTCYNEIGVEGAKSIS 196
                 5555558*********996 PP

  == domain 5  score: 17.0 bits;  conditional E-value: 1.6e-06
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+L++ gN +gDeGa+ 
  EFC36929.1 201 LTSLEIGGNRVGDEGAKF 218
                 9***************96 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 2.1
       LRR_6   5 LteLdL 10 
                 L++Ld+
  EFC36929.1 225 LKSLDI 230
                 99**97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0     0.001       2.7      18      38 ..      98     117 ..      89     125 .. 0.72
   2 !   22.8   0.0   3.4e-08   8.8e-05       1      36 [.     103     139 ..     103     146 .. 0.89
   3 !   22.6   0.1   3.9e-08   9.9e-05       1      38 [.     127     165 ..     127     191 .. 0.90
   4 !   11.6   0.0   0.00012       0.3       1      30 [.     199     230 .]     199     230 .] 0.91

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.001
                 -HHH-TT--EEE-.-S----- CS
       LRR_4  18 lleklpnLkeLdLsgNnlitd 38 
                 ++  +++L+ Ld+ gN +i+d
  EFC36929.1  98 FITEMKQLTLLDIGGN-QIGD 117
                 4556999999999777.8865 PP

  == domain 2  score: 22.8 bits;  conditional E-value: 3.4e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L+ Ld+++Nq+ d +   ++k+++L++L++  Nn+i
  EFC36929.1 103 KQLTLLDIGGNQIGDEGIkpISKMKQLTSLYV-YNNQI 139
                 589************99995557*********.88898 PP

  == domain 3  score: 22.6 bits;  conditional E-value: 3.9e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L+  nNq+   +   ++ +++L++L++sgN +i+d
  EFC36929.1 127 KQLTSLYVYNNQIGVAGAkyIGEMKQLTSLTISGN-YIGD 165
                 58************999985556***********9.9987 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 0.00012
                 SS--EEE--SS---E-S-..HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdL 30 
                 ++L++L +++N++ d +   l  ++ Lk+Ld+
  EFC36929.1 199 KQLTSLEIGGNRVGDEGAkfLIEMKRLKSLDI 230
                 58*************999*8557*******97 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.0   1.8e-05     0.046      14      61 .]      91     139 ..      81     141 .. 0.86
   2 !   28.3   0.0   4.3e-10   1.1e-06       2      60 ..     152     210 ..     151     211 .. 0.98
   3 ?   -2.7   0.0       2.1   5.3e+03      24      31 ..     222     229 ..     218     230 .] 0.56

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.8e-05
                 SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  14 tslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  s+++  F + +++L+ Ld++ N++     + +s +++L+sL++ +N++
  EFC36929.1  91 DSIEKAKFITeMKQLTLLDIGGNQIGDEGIKPISKMKQLTSLYVYNNQI 139
                 56777777777999*********99998889999999999999999997 PP

  == domain 2  score: 28.3 bits;  conditional E-value: 4.3e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +LtsL +s N++ + + ++ + +++L++L+  +N++ +  ++++s +++L+sL + gNr
  EFC36929.1 152 QLTSLTISGNYIGDTGAKFISEMKQLTSLNTCYNEIGVEGAKSISEMKQLTSLEIGGNR 210
                 7*********************************************************8 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 2.1
                 -TT--EEE CS
       LRR_8  24 lsnLkvLd 31 
                 +++Lk+Ld
  EFC36929.1 222 MKRLKSLD 229
                 44555554 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       2.9   7.5e+03       7      15 ..      35      43 ..      26      47 .. 0.75
   2 ?    5.4   0.0     0.014        37       2      20 ..     105     123 ..     104     126 .. 0.78
   3 ?    2.3   0.0      0.15   3.8e+02       1      13 [.     128     140 ..     128     149 .. 0.82
   4 ?    3.7   0.0     0.054   1.4e+02       1      17 [.     152     168 ..     152     174 .. 0.78
   5 ?   -0.6   0.0       1.4   3.5e+03       2      21 ..     177     196 ..     176     198 .. 0.77
   6 ?    1.7   0.0      0.25   6.3e+02       1      13 [.     200     212 ..     200     219 .. 0.80
   7 ?   -1.1   0.1         2   5.1e+03       1       7 [.     224     230 .]     224     230 .] 0.89

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2.9
       LRR_1  7 Lsnnpllgl 15
                L n++l+++
  EFC36929.1 35 LKNCSLISK 43
                668888654 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.014
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ Ld+++n++++ ++  +
  EFC36929.1 105 LTLLDIGGNQIGDEGIKPI 123
                 899*******987776655 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.15
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++L++ nn+++
  EFC36929.1 128 QLTSLYVYNNQIG 140
                 599*******984 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.054
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L +s+n +++ ++
  EFC36929.1 152 QLTSLTISGNYIGDTGA 168
                 599*******9977665 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 1.4
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L++L+ ++n ++  ++ s++
  EFC36929.1 177 LTSLNTCYNEIGVEGAKSIS 196
                 89999999998877777765 PP

  == domain 6  score: 1.7 bits;  conditional E-value: 0.25
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++L +++n+ +
  EFC36929.1 200 QLTSLEIGGNRVG 212
                 599*******864 PP

  == domain 7  score: -1.1 bits;  conditional E-value: 2
       LRR_1   1 nLrhLdL 7  
                 +L++Ld+
  EFC36929.1 224 RLKSLDI 230
                 69****8 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.1   2.7e+03      12      25 ..      42      55 ..      38      69 .. 0.75
   2 ?   11.6   0.0   5.8e-05      0.15      46     124 ..     107     186 ..     100     206 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.1
       LRR_9 12 saqyinairereld 25
                s+q++n i+er   
  EFC36929.1 42 SKQFFNVIKERSKL 55
                68999999999755 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 5.8e-05
       LRR_9  46 tidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                  +d+  n+i +  +  +  +k+l +l++ nn+i   + +    + +l++l +++n + + +  + + ++k+l++l    n 
  EFC36929.1 107 LLDIGGNQIGDegIKPISKMKQLTSLYVYNNQIGVAGAKYIGEMKQLTSLTISGNYIGDTGA-KFISEMKQLTSLNTCYNE 186
                 556666666442255566799*************9999999999***************998.999999999999877665 PP

>> DUF1340  Protein of unknown function (DUF1340)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.1    0.0083        21      53      67 ..      43      57 ..      36     104 .. 0.81
   2 ?    7.6   0.0   0.00086       2.2     135     184 ..     160     208 ..     141     219 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.0083
     DUF1340 53 qrfdnvikersklsp 67
                ++f nvikerskl  
  EFC36929.1 43 KQFFNVIKERSKLFI 57
                6799********965 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00086
     DUF1340 135 aeyimevkgcskqkaktiltaintiyteigiltprkviqlegllsrelfg 184
                  +yi +  g +       lt++nt y eig+   + + +++ l s e+ g
  EFC36929.1 160 GNYIGDT-GAKFISEMKQLTSLNTCYNEIGVEGAKSISEMKQLTSLEIGG 208
                 5666654.566666666789**************9999999999999876 PP

>> Dynein_heavy  Dynein heavy chain region D6 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   8.4e-05      0.22      54      99 ..      29      79 ..       8     102 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.4e-05
                  HT-EEEEE-GGG-.CCCHHHHHHH...........HHTT-EEEEEEES-TT CS
  Dynein_heavy 54 egsWvlLqNchla.pswlkeLekileel....eeklhssfRlwltsepspk 99
                  ++sW +L+Nc l+ +++ + +++  + +    ++ ++++  l++ s+  ++
    EFC36929.1 29 DDSWFILKNCSLIsKQFFNVIKERSKLFiefkTKFTETRIELFMKSQFMNS 79
                  799*********989999999988542244445556667788887776664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (230 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       522  (0.0291148); expected 358.6 (0.02)
Passed bias filter:                      250  (0.0139439); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1487.61
//
Query:       EFC36930.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-06   27.0   0.2    3.7e-05   23.4   0.1    2.9  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.22     4e+03      12      20 ..      71      79 ..      70      80 .. 0.83
   2 ?   -0.9   0.0     0.087   1.6e+03      14      27 ..     109     122 ..     108     123 .. 0.82
   3 !   23.4   0.1   2.1e-09   3.7e-05       1      30 []     153     182 ..     153     182 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.22
      RCC1_2 12 caLtedGeV 20
                ++Lt dG++
  EFC36930.1 71 VVLTYDGTI 79
                699****87 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.087
      RCC1_2  14 LtedGeVlcWGsNs 27 
                 L ++ ++++ G+++
  EFC36930.1 109 LASSHDLYARGDDN 122
                 678899*****987 PP

  == domain 3  score: 23.4 bits;  conditional E-value: 2.1e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++ +G+++s++L+ ++e+l++G N+  Q
  EFC36930.1 153 IRDIQCGYFFSVVLLHNNELLACGYNGLNQ 182
                 689***********************9777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       374  (0.0208601); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1424.02
//
Query:       EFC36931.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.8e-05   24.4   0.0    0.00034   20.9   0.0    2.6  2  Helicase_C  Helicase conserved C-terminal domain
  ------ inclusion threshold ------
      0.033   13.9   0.0      0.097   12.4   0.0    1.8  1  DEAD        DEAD/DEAH box helicase


Domain annotation for each model (and alignments):
>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.14   1.2e+03      12      40 ..      53      84 ..      41     132 .. 0.75
   2 !   20.9   0.0   3.8e-08   0.00034       4     101 ..     209     302 ..     206     310 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.14
                HTTTTSEEEEEESSHHHHHHHHHHHHHT...T CS
  Helicase_C 12 leeeggkilifvntidrlekvklllekk...g 40
                ++e++g+++++ n ++ ++ v++ll++    +
  EFC36931.1 53 RNEKNGTTIVIGNGWQWAYTVRYLLKSLggdD 84
                56788888998898887766777765544333 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 3.8e-08
                 HHHHHHHHHTTTTSEEEEEESSHHHHHH.HHHHHHHTTSTEEEESTTSTHHHHHHHHHHHHTTSSSEEEESGGGTSSSTSTTESEEEESSSSSSHHHHH CS
  Helicase_C   4 eallellkleeeggkilifvntidrlek.vklllekkgikvavlhgelpqnereeileqfnkgesdvLiatdvaerGidipkvnlVinfdlprnvtsyi 101
                 e++ +l+    +g ++++++++ ++++  ++ l  +  + va+lh  l   + eei ++fn  ++++L +td  ++ +      lVin+dlp++ ++y 
  EFC36931.1 209 ETISDLF-DILDGLRAVVYCESDEKAKAiCEKL--QDRFLVACLHRGLGETQIEEIRQDFNWAKVRFLFTTDHFSK-LEY-HPVLVINYDLPWQNEKYA 302
                 5555555.5568999*********996566666..5689**********************99***********99.555.3579*******9987774 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.1e-05     0.097      70     133 ..      76     138 ..      39     145 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.1e-05
                 HTTTST...SEEEEEETTSSHHHHHHHHHTTCSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHH CS
                 xxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  70 fkkyid...lrvlliiggvaardqlskldngvdivvgtpgrlddllstgklnlsqvrflVlDEadrl 133
                 ++k ++   l+v+l+++g +a    s+++ + d++vg    + +l+++g+l+ ++v++l++D a  l
  EFC36931.1  76 LLKSLGgddLKVCLCLEGFRA----STFQGNEDVIVGICNNVNNLVNSGSLKAKDVNLLIIDQANHL 138
                 444433334888888888666....6775669******************************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.21s 00:00:00.61 Elapsed: 00:00:00.35
# Mc/sec: 2958.77
//
Query:       EFC36932.1  [L=433]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-06   28.8   0.0     0.0082   16.7   0.0    3.0  2  RCC1      Regulator of chromosome condensation (RCC1) repeat
      3e-06   26.9   4.2      0.047   13.5   0.0    3.6  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
       0.17   11.7   1.0       0.38   10.6   1.0    1.5  1  XET_C     Xyloglucan endo-transglycosylase (XET) C-terminus


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0   0.00041       2.5       2      50 .]     196     248 ..     195     248 .. 0.73
   2 !   16.7   0.0   1.4e-06    0.0082       1      45 [.     251     299 ..     251     304 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00041
                 TEEEEEE--GGGTTSSSS---E.....EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesv.....lvPtkveglsgnrvvkvacGddhtval 50 
                 Gr+  +G+n +G LG   ++++      +P   + ++   ++k acGd+  v++
  EFC36932.1 196 GRLMICGSNGFGELGFDVKDNKtekldVHPIHKQDPN-LFFTKTACGDHNIVVI 248
                 778889**********665444223434497776664.49********998876 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 1.4e-06
                 TTEEEEEE--GGGTTSSSS---E..EEEEE-..GGGTTS..-EEEEEEETT CS
        RCC1   1 dGrVysWGrndyGqLGlgttesv..lvPtkv..eglsgn..rvvkvacGdd 45 
                 +G Vy  G n+ + LGl +t sv  l P+k+  e       ++++vac ++
  EFC36932.1 251 EGLVYVTGYNSSNELGLSSTSSVfqLQPSKLfnEYA--AkdPFIDVACHYY 299
                 79***************9997775588****54444..356*******887 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1      0.65   3.9e+03       4      16 ..      84      96 ..      84      96 .. 0.87
   2 !   13.0   0.2   1.1e-05     0.068       5      29 ..     183     207 ..     179     208 .. 0.87
   3 !   13.5   0.0   7.8e-06     0.047       3      28 ..     237     262 ..     235     264 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.65
      RCC1_2  4 vsaGdyHscaLte 16
                v++ + H ++Lt+
  EFC36932.1 84 VASSYGHVMFLTD 96
                788999****996 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 1.1e-05
      RCC1_2   5 saGdyHscaLtedGeVlcWGsNsdG 29 
                 s+ +y s+ Lt+ G+++ +GsN++G
  EFC36932.1 183 SCAAYTSILLTNHGRLMICGSNGFG 207
                 5667999****************99 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 7.8e-06
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGsNsd 28 
                 + ++Gd   +++t +G V+ +G Ns+
  EFC36932.1 237 KTACGDHNIVVITKEGLVYVTGYNSS 262
                 569*********************96 PP

>> XET_C  Xyloglucan endo-transglycosylase (XET) C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   1.0   6.4e-05      0.38      27      41 ..     369     383 ..     366     386 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 6.4e-05
       XET_C  27 ymiYdYCtDtkRfpq 41 
                 ++  +YC+D+ R+  
  EFC36932.1 369 HTAHNYCYDSHRYSS 383
                 6778*********75 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (433 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       422  (0.0235373); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2661.81
//
Query:       EFC36933.1  [L=597]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.8e-07   30.0  23.3    4.3e-07   29.4  23.3    1.2  1  CitMHS         Citrate transporter
    9.6e-07   28.2  22.9    1.3e-06   27.8  22.9    1.1  1  Na_sulph_symp  Sodium:sulfate symporter transmembrane region
     0.0039   16.1  15.8     0.0039   16.1  15.8    1.6  2  DctM           Tripartite ATP-independent periplasmic transpo


Domain annotation for each model (and alignments):
>> CitMHS  Citrate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4  23.3   7.2e-11   4.3e-07      10     163 ..     425     587 ..     405     594 .. 0.75

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 7.2e-11
                 xxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      CitMHS  10 rldvvallvlvll.vltieealsgiaspiillllgamiigaaleetGlfdrlaakllrlaggkrd.llvllvlltallsafvsndgvvlimipivlsla 106
                   ++v ++v++++ ++++ +a++ i++ +++l+++ + ig+a++++G+ + +++ l  +       l++++ ++t +++ +++  +vv+i+ipi++++a
  EFC36933.1 425 QCSLVTFCVVIMFgLISPTDAIESIDWALVALVGASFGIGSAITQSGVGQGITQVLKLANVP-HIlLPAFITAITLVVANVITSSAVVAICIPIAVAIA 522
                 55678887777889**************************************9988765555.5669999************99*************** PP

                 xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxxx RF
      CitMHS 107 krlkklppl.lliplalaaniggaltpiGtpttraa.........arpglslpnllllalllvgllp 163
                 ++  +l+++ +++ +++a++    + p G +  + +         + ++  +p  +l +l++ +l+p
  EFC36933.1 523 QS-YGLNARcFVMCVIYASQSVF-TFPLGFSGNMLVmgvgnykfvDFVKAGVPLTILYWLIISVLVP 587
                 *9.555555599*********98.6677777111113445555543333333333334444444444 PP

>> Na_sulph_symp  Sodium:sulfate symporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.8  22.9   2.2e-10   1.3e-06     291     466 ..     424     591 ..     399     594 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.8 bits;  conditional E-value: 2.2e-10
  Na_sulph_symp 291 idattvaivvlvillllrvldWkDivkqktaWntllllgglialakllersgliewlgnklttsls.glspavaiiiilslfvlvhylfaSatAtt 385
                    ++ + v++    ++++  +++  D ++    W  + l g+  ++ +  ++sg    +g+ +t+ l+ + +p +++ + ++++ lv       +A +
     EFC36933.1 424 VQCSLVTF---CVVIMFGLISPTDAIE-SIDWALVALVGASFGIGSAITQSG----VGQGITQVLKlANVPHILLPAFITAITLVVANVITSSAVV 511
                    44455554...4455667788887765.689*********************....88888888888889***********99999999999**** PP

  Na_sulph_symp 386 aallpillavaqaipgappllvalllalatslagfllpyatgpnpivfgagylkvkdywrlGfilsiigllillllg.alww 466
                    a+ +pi +a+aq+  g +   +++ +  a+  + f+ p++ + n++v g+g  k  d+ ++G++l+i++ li+ +l  a+w+
     EFC36933.1 512 AICIPIAVAIAQSY-GLNARCFVMCVIYASQSV-FTFPLGFSGNMLVMGVGNYKFVDFVKAGVPLTILYWLIISVLVpAIWG 591
                    **************.877777777777777666.8*********************************98877555405554 PP

>> DctM  Tripartite ATP-independent periplasmic transporter, DctM component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   2.0      0.38   2.3e+03     312     347 ..     405     440 ..     400     457 .. 0.74
   2 !   16.1  15.8   6.6e-07    0.0039     277     407 ..     452     580 ..     443     590 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.38
        DctM 312 kllfLilvnllvlvlGmfldttaaiiilvpilaPaa 347
                 +++++  +++ + + G  +   +++++ v+i++ ++
  EFC36933.1 405 WIFLFFSAMIACTIAGYSMVQCSLVTFCVVIMFGLI 440
                 455555667778888888888888888888887665 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 6.6e-07
        DctM 277 avlfilaaagifaglltltgvplklselllslsggkllfLilvnllvlvlGmfldttaaiiilvpilaPaaaklgidpihfgvvivlnlsiglitPPvG 375
                 a+++++ a+  +  ++t +gv++ ++++l       +l+ + ++++ lv++ +++ +a++ i  pi++++a+  g++   f + ++ ++s + +t P+G
  EFC36933.1 452 ALVALVGASFGIGSAITQSGVGQGITQVLKLANVPHILLPAFITAITLVVANVITSSAVVAICIPIAVAIAQSYGLNARCFVMCVI-YASQSVFTFPLG 549
                 4566777777788899************999998999888999**********************************999976665.567799****** PP

        DctM 376 lalfv.assiakvsveeivkalvPflvvlvval 407
                 +   +   ++++ ++++ vka vP  ++    l
  EFC36933.1 550 FSGNMlVMGVGNYKFVDFVKAGVPLTILY--WL 580
                 987651689***************86543..23 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (597 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1367  (0.0762452); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.76u 0.31s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 3566.44
//
Query:       EFC36934.1  [L=186]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.1e-19   69.7   9.7      8e-10   39.0   0.9    3.2  3  EF-hand_7     EF-hand domain pair
    8.7e-18   62.5  16.2    1.9e-05   23.9   0.5    5.0  6  EF-hand_1     EF hand
    3.5e-17   61.0  12.0    0.00016   21.0   0.1    4.8  5  EF-hand_5     EF hand
    6.5e-17   60.0  13.3    6.8e-05   22.5   0.4    5.7  6  EF-hand_6     EF-hand domain
    8.8e-12   44.7  12.2    5.7e-06   26.1   0.4    4.8  4  EF-hand_8     EF-hand domain pair
      0.006   16.9   2.2          7    7.0   0.2    3.4  2  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
  ------ inclusion threshold ------
      0.034   14.5   0.2      0.034   14.5   0.2    2.5  3  EF-hand_14    EF-hand domain
      0.073   13.2   0.6        1.1    9.4   0.1    2.3  2  p25-alpha     p25-alpha
       0.11   12.6   0.1        1.7    8.8   0.0    2.8  3  La            La domain


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.1   2.3e-05     0.046      17      71 .]       3      52 ..       2      52 .. 0.93
   2 !   21.7   0.2   1.1e-07   0.00021      44      67 ..      62      85 ..      59      89 .. 0.90
   3 !   39.0   0.9     4e-13     8e-10       6      70 ..     106     176 ..     101     177 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.3e-05
   EF-hand_7 17 gyldkeellrllrkifqgagegsklsdeelellfke.fDtdkdGvisfdEFlklyr 71
                g++++ee++  lrk     ++  kl+++e+++  k  fD+ kdG ++ + F+k+ +
  EFC36934.1  3 GKISREEMK-TLRK-----ETRGKLDQKEIQKYHKFwFDLYKDGNMTKEGFVKFAQ 52
                89*****99.9999.....999999*******999966**************9975 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 1.1e-07
   EF-hand_7 44 eelellfkefDtdkdGvisfdEFl 67
                + +++lf+ +D ++dG+++f EFl
  EFC36934.1 62 TDVDYLFRAMDNNNDGTVTFKEFL 85
                469********************8 PP

  == domain 3  score: 39.0 bits;  conditional E-value: 4e-13
   EF-hand_7   6 eaFkelDtdgdgyldkeellrllrkifqga.....gegsklsd...ee....lellfkefDtdkdGvisfdEFlkly 70 
                  aF+++D d+dg+++++e+++ l+++f ++     +      +    +    +  l+   D+++dG+++++E  +++
  EFC36934.1 106 LAFDMYDEDRDGFVTVDEMRESLHNMFKAKgmnvnD------PnvkNQienrINNLLSLADKNNDGKLTREEIFTAC 176
                 47*******************988888766553331......233333333477888888************88776 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.016        31      15      26 ..       3      14 ..       3      17 .. 0.86
   2 ?   -2.2   0.0       2.1   4.2e+03      15      24 ..      19      28 ..      19      29 .. 0.82
   3 ?   -2.9   0.1       3.3   6.6e+03      13      20 ..      38      45 ..      34      50 .. 0.69
   4 !   23.9   0.5   9.6e-09   1.9e-05       2      23 ..      64      85 ..      63      88 .. 0.91
   5 !   22.7   0.8   2.2e-08   4.4e-05       2      26 ..     104     128 ..     103     131 .. 0.88
   6 !   20.0   0.1   1.6e-07   0.00032       2      27 ..     152     177 ..     151     179 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.016
                SEEEHHHHHHHH CS
   EF-hand_1 15 GkIdfeEfkell 26
                GkI++eE+k+l 
  EFC36934.1  3 GKISREEMKTLR 14
                9*******9975 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2.1
                SEEEHHHHHH CS
   EF-hand_1 15 GkIdfeEfke 24
                Gk+d +E ++
  EFC36934.1 19 GKLDQKEIQK 28
                8999999875 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 3.3
                SSSEEEHH CS
   EF-hand_1 13 gdGkIdfe 20
                +dG +++e
  EFC36934.1 38 KDGNMTKE 45
                67777765 PP

  == domain 4  score: 23.9 bits;  conditional E-value: 9.6e-09
                HHHHHHHHTTTSSSEEEHHHHH CS
   EF-hand_1  2 lkeiFrefDkDgdGkIdfeEfk 23
                ++ +Fr +D ++dG+++f+Ef+
  EFC36934.1 64 VDYLFRAMDNNNDGTVTFKEFL 85
                7899*****************7 PP

  == domain 5  score: 22.7 bits;  conditional E-value: 2.2e-08
                 HHHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkell 26 
                 ++ +F+++D D+dG+++ +E++e l
  EFC36934.1 104 IDLAFDMYDEDRDGFVTVDEMRESL 128
                 6779*****************9866 PP

  == domain 6  score: 20.0 bits;  conditional E-value: 1.6e-07
                 HHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellk 27 
                 ++++ +++Dk++dGk+++eE  ++++
  EFC36934.1 152 INNLLSLADKNNDGKLTREEIFTACE 177
                 6778899*************999886 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.1    0.0008       1.6      14      24 ..       3      13 ..       3      13 .. 0.94
   2 ?   -2.3   0.0       1.8   3.7e+03      14      22 ..      19      27 ..      19      28 .. 0.83
   3 !   21.0   0.1   7.8e-08   0.00016       3      22 ..      65      85 ..      64      88 .. 0.88
   4 !   18.6   0.2   4.5e-07   0.00091       3      23 ..     105     126 ..     103     129 .. 0.86
   5 !   18.5   0.1   5.1e-07     0.001       2      20 ..     153     171 ..     152     172 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0008
                SCE-HHHHHHH CS
   EF-hand_5 14 GkIskeELktl 24
                GkIs+eE ktl
  EFC36934.1  3 GKISREEMKTL 13
                9*******996 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.8
                SCE-HHHHH CS
   EF-hand_5 14 GkIskeELk 22
                Gk++  E +
  EFC36934.1 19 GKLDQKEIQ 27
                999999987 PP

  == domain 3  score: 21.0 bits;  conditional E-value: 7.8e-08
                H.HHHHH-SS-SSCE-HHHHH CS
   EF-hand_5  3 d.tFqaiDlNgDGkIskeELk 22
                d +F+a+D N+DG++++ E+ 
  EFC36934.1 65 DyLFRAMDNNNDGTVTFKEFL 85
                558****************95 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 4.5e-07
                 H.HHHHH-SS-SSCE-HHHHHH CS
   EF-hand_5   3 d.tFqaiDlNgDGkIskeELkt 23 
                 d +F++ D ++DG+++++E ++
  EFC36934.1 105 DlAFDMYDEDRDGFVTVDEMRE 126
                 558****************997 PP

  == domain 5  score: 18.5 bits;  conditional E-value: 5.1e-07
                 HHHHHHH-SS-SSCE-HHH CS
   EF-hand_5   2 kdtFqaiDlNgDGkIskeE 20 
                 + +++ +D+N+DGk+++eE
  EFC36934.1 153 NNLLSLADKNNDGKLTREE 171
                 667889************9 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.54   1.1e+03      15      23 ..       3      11 ..       2      13 .. 0.87
   2 ?    1.9   0.0      0.13   2.7e+02      15      25 ..      19      29 ..      18      33 .. 0.87
   3 ?    1.4   0.1       0.2     4e+02       9      25 ..      34      50 ..      31      54 .. 0.78
   4 !   22.0   0.5   4.7e-08   9.4e-05       2      23 ..      64      85 ..      63      89 .. 0.90
   5 !   22.5   0.4   3.4e-08   6.8e-05       5      26 ..     107     128 ..     103     135 .. 0.88
   6 !   15.5   0.0   5.9e-06     0.012       2      27 ..     152     177 ..     151     183 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.54
   EF-hand_6 15 GkidaeElr 23
                Gki++eE++
  EFC36934.1  3 GKISREEMK 11
                9******97 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.13
   EF-hand_6 15 GkidaeElrka 25
                Gk+d++E++k 
  EFC36934.1 19 GKLDQKEIQKY 29
                9*******996 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.2
   EF-hand_6  9 fDkdgdGkidaeElrka 25
                fD  +dG  ++e ++k+
  EFC36934.1 34 FDLYKDGNMTKEGFVKF 50
                67778898888888776 PP

  == domain 4  score: 22.0 bits;  conditional E-value: 4.7e-08
   EF-hand_6  2 lreaFklfDkdgdGkidaeElr 23
                ++++F+++D+++dG+++++E+ 
  EFC36934.1 64 VDYLFRAMDNNNDGTVTFKEFL 85
                5799*****************7 PP

  == domain 5  score: 22.5 bits;  conditional E-value: 3.4e-08
   EF-hand_6   5 aFklfDkdgdGkidaeElrkal 26 
                 aF+++D d+dG+++ +E+r  l
  EFC36934.1 107 AFDMYDEDRDGFVTVDEMRESL 128
                 9****************99755 PP

  == domain 6  score: 15.5 bits;  conditional E-value: 5.9e-06
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalr 27 
                 ++ +  l Dk++dGk+++eE+  a+ 
  EFC36934.1 152 INNLLSLADKNNDGKLTREEIFTACE 177
                 56677889************987765 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.2    0.0097        19       2      28 ..       2      26 ..       2      28 .. 0.67
   2 !   26.1   0.4   2.9e-09   5.7e-06       2      49 ..      39      85 ..      38      88 .. 0.76
   3 !    5.6   0.4    0.0069        14      23      47 ..      98     123 ..      94     130 .. 0.81
   4 !   16.7   0.2   2.5e-06    0.0049       2      50 ..     116     174 ..     115     178 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0097
   EF-hand_8  2 kgkItreelrrilrilglkk...glseeev 28
                +gkI+ree+++       k+   +l  +e+
  EFC36934.1  2 GGKISREEMKT-----LRKEtrgKLDQKEI 26
                69********9.....33323556666665 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 2.9e-09
   EF-hand_8  2 kgkItreelrril.rilglkkglseeevdilfrefDtdgdGkisfeEFc 49
                +g +t+e +++++  +l      +  +vd lfr++D ++dG+++f+EF+
  EFC36934.1 39 DGNMTKEGFVKFAqLALPNW--DGQTDVDYLFRAMDNNNDGTVTFKEFL 85
                67788888888773333211..24568*********************6 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0069
   EF-hand_8  23 lseee.vdilfrefDtdgdGkisfeE 47 
                 l++ e +d  f+  D+d+dG ++ +E
  EFC36934.1  98 LNPMElIDLAFDMYDEDRDGFVTVDE 123
                 56666688889999999999999998 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 2.5e-06
   EF-hand_8   2 kgkItreelrril.rilglkk.........glseeevdilfrefDtdgdGkisfeEFcv 50 
                 +g +t++e+r+ l ++++ k+            e+ +  l++++D ++dGk++ eE + 
  EFC36934.1 116 DGFVTVDEMRESLhNMFKAKGmnvndpnvkNQIENRINNLLSLADKNNDGKLTREEIFT 174
                 7999*******9999996666677988765444566********************876 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.1    0.0049       9.8      55     110 ..      63      84 ..       4      95 .. 0.66
   2 !    7.0   0.2    0.0035         7      85     110 ..     147     172 ..      91     176 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0049
  SPARC_Ca_bdg  55 pvawkFsklDtnsdkvlsksELaplraplvklehCikpflescDadkdkkislkEw 110
                    v + F  +D n+d+++                                  + kE+
    EFC36934.1  63 DVDYLFRAMDNNNDGTV----------------------------------TFKEF 84 
                   34455555555555555..................................55554 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0035
  SPARC_Ca_bdg  85 klehCikpflescDadkdkkislkEw 110
                   ++e+ i+++l+ +D ++d+k++++E 
    EFC36934.1 147 QIENRINNLLSLADKNNDGKLTREEI 172
                   56777888888888888888888773 PP

>> EF-hand_14  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1       1.2   2.5e+03      60      69 ..      31      48 ..       7      53 .. 0.47
   2 ?   -0.9   0.1       1.1   2.2e+03       3      23 ..      65      85 ..      64      88 .. 0.88
   3 ?   14.5   0.2   1.7e-05     0.034       3      71 ..     105     176 ..     103     184 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.2
  EF-hand_14 60 t........leldretFk 69
                +         ++ +e F 
  EFC36934.1 31 KfwfdlykdGNMTKEGFV 48
                133333333555555554 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.1
  EF-hand_14  3 dllfdlfkdeetdklsvakll 23
                d lf  +++++++++ ++++l
  EFC36934.1 65 DYLFRAMDNNNDGTVTFKEFL 85
                889999999999999999986 PP

  == domain 3  score: 14.5 bits;  conditional E-value: 1.7e-05
  EF-hand_14   3 dllfdlfkdeetdklsvakllkaL....aetGirkdDpRLkellkk.lkkvekekseaeesetleldret.Fkkc 71 
                 dl fd+++++ ++ + v ++ ++L    +++G++ +Dp +k+ +++ ++++        + ++ +l re+ F +c
  EFC36934.1 105 DLAFDMYDEDRDGFVTVDEMRESLhnmfKAKGMNVNDPNVKNQIENrINNLLSLA---DKNNDGKLTREEiFTAC 176
                 899*****99*******99887772222578*********998875255555553...45566777765426666 PP

>> p25-alpha  p25-alpha
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1   0.00054       1.1      41      68 ..      61      88 ..      23      99 .. 0.83
   2 ?    2.2   0.0     0.089   1.8e+02      44      86 ..     104     150 ..     100     178 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00054
   p25-alpha 41 stdvDiiFsKvkaksarkitfeqfkeal 68
                +tdvD +F+ + ++++ ++tf++f  + 
  EFC36934.1 61 QTDVDYLFRAMDNNNDGTVTFKEFLLFQ 88
                79**********************8765 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.089
   p25-alpha  44 vDiiFsKvkaksarkitfeqfkealeelaekkfkkkkkeeel.......e 86 
                 +D++F    +  +  +t++++ e l ++ + k    +++++        +
  EFC36934.1 104 IDLAFDMYDEDRDGFVTVDEMRESLHNMFKAKG---MNVNDPnvknqieN 150
                 699999999999999************999944...44333311233333 PP

>> La  La domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0       0.6   1.2e+03      21      37 ..      39      53 ..      32      55 .. 0.74
   2 ?    8.8   0.0   0.00083       1.7      18      44 ..      65      91 ..      62     108 .. 0.87
   3 ?   -1.7   0.0       1.5     3e+03      25      35 ..     112     122 ..     106     131 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.6
                HHHHTTSTTS---HHHH CS
          La 21 rkkmdkdpegwVplsli 37
                  +m+k  eg+V+ + +
  EFC36934.1 39 DGNMTK--EGFVKFAQL 53
                567888..999998876 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00083
                HHHHHHHTTSTTS---HHHHHTSSHHH CS
          La 18 kFLrkkmdkdpegwVplsliasfkrmk 44
                ++L++ md++++g V  + ++ f+ + 
  EFC36934.1 65 DYLFRAMDNNNDGTVTFKEFLLFQSIT 91
                59*******************999886 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.5
                 TTSTTS---HH CS
          La  25 dkdpegwVpls 35 
                 d+d +g+V ++
  EFC36934.1 112 DEDRDGFVTVD 122
                 78889999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       887  (0.0494729); expected 358.6 (0.02)
Passed bias filter:                      596  (0.0332422); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 1244.61
//
Query:       EFC36935.1  [L=475]
Description: serine carboxypeptidase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     4e-114  382.3   3.5   4.6e-114  382.1   3.5    1.0  1  Peptidase_S10  Serine carboxypeptidase


Domain annotation for each model (and alignments):
>> Peptidase_S10  Serine carboxypeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  382.1   3.5  2.5e-118  4.6e-114       1     417 [.      33     473 ..      33     475 .] 0.93

  Alignments for each domain:
  == domain 1  score: 382.1 bits;  conditional E-value: 2.5e-118
                    TTCSST-SSEEEEEEEECSTTTTEEEEEEEEE-SSGTTTS-EEEEE--TTTB-THHHHHHTTSSEEEETTTTSEEEE-TT-GGGCSEEEEE--STT CS
  Peptidase_S10   1 PgleetvnfkqysGYldveeeedkslFYwfveseknpeedplvlWLnGGPGCsSldGlleElGPfrvnkdstkkleenpysWnkvanvlfldqPvG 96 
                    Pg+ + ++f qy+G++ v+ +++++lFYwfves++np++dp+vlW+nGGPGCsSldG+++E+GPf +n d +++l+en+ysWnk  n+++l++P  
     EFC36935.1  33 PGFVGDIKFAQYAGFVPVNVTAQRNLFYWFVESQNNPSTDPVVLWMNGGPGCSSLDGFVTEHGPFLLN-D-GQTLRENEYSWNKRVNMIYLESPFE 126
                    8888999*************************************************************.5.59*********************** PP

                    STT-EETTSSGS--SHHHHHHHHHHHHHHHH.HHSTCGTTSEEEEEEETTHHHHHHHHHHHHHTHCCH--SSTSEEEEEEEESE-SBHHHHHCCHH CS
  Peptidase_S10  97 vGFSysntksdvktddeevaedlyefLkkff.ekfpeyksrdfyitGESYaGhyvPalakeilkknkkekkkkinLkGlligNglideaeqvnsyv 191
                    vG+Sys +k+   ++d + a+d+++fL+ ff e fp++++++fyi++ESY+Ghy P+ a ++l +        +nLkG+++ Ng++d+ e++ns++
     EFC36935.1 127 VGYSYSVQKDL-VWNDVKSADDVVKFLHTFFfELFPQFAKNPFYIAAESYGGHYGPTSAVAVLRSGY-----PFNLKGFIVANGIMDDREDTNSIP 216
                    ********987.8***************976266*****************************9985.....59********************** PP

                    HHHHHTTSSHHHHHHHHHHHHEETHHHHHHHHHHHHHHHHHHHHHHHHHCHCEETTETTSEETT..SSEE.......................... CS
  Peptidase_S10 192 efayehgliseeeyeslkkacekkeeleqesekcanllekaskvavekenkglnvynileecck..lkae.......................... 259
                     f+y+h+lis++ y++   +c ++ +++q+  +ca+ ++++ +        g+n+y+i+ +c+                                 
     EFC36935.1 217 IFMYQHSLISKSAYDEGLAKCRGDFYANQQLPECADVISNYYTS-----IVGINPYDIYDKCVGdvG--Pfdaatsntdilkqngwfktltkkqpy 305
                    *****************************************874.....459**********77651..2445678899***************** PP

                    ......HHHCTTCCCCTTTTTCHHHHHHHHTSHHHHHHTT--..TTSSS--SB-HHHHHHCTCCC-SBCHHHHHHHHHTT-EEEEEEETT-STT-H CS
  Peptidase_S10 260 ......lkksstdaqggedpydesyvekylnkkeVrkalhvn..asvkkweecndsvfeqleddisksveeileellesglrvliynGdvDlicnv 347
                          l + s++  +g  +  ++  e ++n ++V+ al++n     +kw++cnd v + +++++++s++++++ell++g+r l  +GdvDl++n 
     EFC36935.1 306 dtkihpLFTLSQRVGSGAPCLAYKPQEYWFNLPQVKAALNANsmPAGHKWQMCNDVV-NGNYNRTYSSMIPFYQELLSKGIRGLFVSGDVDLAVNS 400
                    ****99778889999***************************99888********99.999*********************************** PP

                    HHHHHHHHH....TECTTECCSCCCEEEETTTCESEEEEEEEE....TTEEEEEETT--SSHHHHSHHHHHHHHHHHH CS
  Peptidase_S10 348 lgteawikk....lelsgkkefrpwevspkkengqvaGyvkey....enltfltvkgaGHmvPedkpeealqllerfi 417
                    lg+++ i +    ++ s+k++f++w +     n+qv G+++ +    + ltf tvkgaGHm P++ p  +++ +  f+
     EFC36935.1 401 LGSQNGIYAlmktMNGSIKTPFTSWST-----NKQVTGFYQIWsagsTTLTFKTVKGAGHMIPMKYPALSQKAFYDFV 473
                    ****88777666699999999999999.....9********99654344************************99998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       384  (0.0214178); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 2712.32
//
Query:       EFC36936.1  [L=386]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.1e-11   44.0   0.5    6.8e-11   42.4   0.2    2.0  2  FHA            FHA domain
      9e-07   29.1   0.0    7.4e-06   26.2   0.0    2.4  2  Yop-YscD_cpl   Inner membrane component of T3SS, cytoplasmic 
  ------ inclusion threshold ------
        7.2    6.8   9.8        2.2    8.4   6.7    1.7  2  Mannitol_dh    Mannitol dehydrogenase Rossmann domain


Domain annotation for each model (and alignments):
>> FHA  FHA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.4   0.2   1.1e-14   6.8e-11       1      54 [.      73     126 ..      73     142 .. 0.88
   2 ?   -3.5   0.0       2.4   1.4e+04      32      43 ..     335     346 ..     328     358 .. 0.68

  Alignments for each domain:
  == domain 1  score: 42.4 bits;  conditional E-value: 1.1e-14
                 EEEESSTT.SSEETTSTTSTTTEEEEEEETTCEEEEEEEESSSSSEEETTEEEST CS
         FHA   1 vtiGRssd.cdivlddpsiSrkHalikfdkgsgkvyleDlgSknGtfvNgqrigk 54 
                 +++G+ +d ++iv ++ +iSr+H++i+  k+ g+vyl Dl S nGtf N+++ + 
  EFC36936.1  73 YVFGKQEDlSHIVCENITISRQHCIIQHAKN-GRVYLYDLASANGTFWNNKKHQC 126
                 678888555999999****************.******************98775 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.4
                 EEEEEEEESSSS CS
         FHA  32 gkvyleDlgSkn 43 
                   v ++Dl Sk 
  EFC36936.1 335 ELVQVQDLISKT 346
                 367888887775 PP

>> Yop-YscD_cpl  Inner membrane component of T3SS, cytoplasmic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.0   1.2e-09   7.4e-06      10      72 ..      63     127 ..      54     145 .. 0.81
   2 ?   -0.8   0.1      0.32   1.9e+03      46      70 ..     333     357 ..     328     366 .. 0.81

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 1.2e-09
                   -EEEE.TTEEEEEES-TT.-SEE---TTS-TT-EEEEEE.TTEEEEEE-CESS--EETTEE-SECC CS
  Yop-YscD_cpl  10 aeveL.eegevviGsded.cDivLsDkevsrkhlkLeve.eesvrledlgsrngllvngerveele 72 
                   +++++ ++g +v+G++ed + iv +  ++sr+h+ ++   + +v l dl+s ng++ n+++++  +
    EFC36936.1  63 ETIDIsKQGFYVFGKQEDlSHIVCENITISRQHCIIQHAkNGRVYLYDLASANGTFWNNKKHQ-CK 127
                   56666577889*************************9874778*****************996.33 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.32
                   ETTEEEEEE-CESS--EETTEE-SE CS
  Yop-YscD_cpl  46 eeesvrledlgsrngllvngervee 70 
                   e+e v+++dl s+ + + ++++ ++
    EFC36936.1 333 EDELVQVQDLISKTKPVADKKQNKK 357
                   6888999***999999999988764 PP

>> Mannitol_dh  Mannitol dehydrogenase Rossmann domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.1   6.6e+03     101     126 ..     154     179 ..     147     192 .. 0.47
   2 ?    8.4   6.7   0.00037       2.2      26     143 ..     245     362 ..     236     366 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.1
                  -TTTBETTTEB-TTSHHHHHHHH-TT CS
  Mannitol_dh 101 tekGidatgeletdlpaiaadlakpe 126
                  +e+  +a  +le++l++ +++l+ +e
   EFC36936.1 154 GEEDEEAVRKLEDELKRKKTSLELEE 179
                  44333344445555555555554443 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00037
                  --TT-EEEEEE-STTHHHHHHHTTTT-EEEEE-SSS---EEEE--EEEEEEGGG-HHHHHHHHTSTT--EEEE---TTT.BE.TTTEB-TTSHHHHHH CS
  Mannitol_dh  26 egldwgivevnlrevdareaLkaqdelyvviekgeeskearlvgsvnavlsveedlealieamaePeirivsltvtekG.id.atgeletdlpaiaad 121
                  e++ ++i++ +++  +   + ++q +l+ v +++e +ke ++ ++ ++    +e+ ++l + ma  ++ +++ ++ +k  i+ + ++le++l +++ +
   EFC36936.1 245 EDNTISIIDTKPTDMQGLLDKQEQIKLQLVGLRKELDKEIEMLEQQKNSSVEDEEEDELEKYMATIKTSLITQNTEKKNkIEeEIKKLEDELVQVQDL 342
                  67777788877777777333344555666666667777777888777777777779******************99998999999************* PP

                  HH-TTHHHHHHHHHHHTT---- CS
  Mannitol_dh 122 lakpellvealkrrraaglkpl 143
                  + k++ ++++ +++++  ++  
   EFC36936.1 343 ISKTKPVADKKQNKKQ--AQDA 362
                  ***9855554444444..4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (386 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3133  (0.174745); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 2238.09
//
Query:       EFC36937.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0015   18.8   0.6     0.0098   16.2   0.1    2.3  2  BTB_2       BTB/POZ domain
     0.0045   16.8   1.3     0.0076   16.0   1.3    1.3  1  Nsp1_C      Nsp1-like C-terminal region
  ------ inclusion threshold ------
      0.012   15.5   0.2      0.033   14.1   0.1    1.8  1  HetR_C      Heterocyst differentiation regulator C-terminal H
      0.065   12.9   0.9       0.28   10.9   0.9    2.0  1  HARP        HepA-related protein (HARP)
        2.4    8.3   7.3       0.69   10.0   3.5    1.8  2  ADIP        Afadin- and alpha -actinin-Binding
        3.9    7.6   6.8        2.7    8.1   0.1    3.0  3  Mst1_SARAH  C terminal SARAH domain of Mst1


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0         2   5.9e+03      76      76 ..      31      31 ..       8      48 .. 0.56
   2 !   16.2   0.1   3.3e-06    0.0098       1      48 [.      56     122 .]      56     122 .] 0.65

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2
                H CS
       BTB_2 76 s 76
                +
  EFC36937.1 31 M 31
                2 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 3.3e-06
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG........................GGEETTTTEEEE-S CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkte....................elddydeetneyffDR 48 
                 +kln+gG++f++ k+tLs+k   +  + ++ +                    +++ +++e++ +f+DR
  EFC36937.1  56 IKLNIGGKKFNVMKETLSQKIIRIDYDSEE-DgedeekkyypphlfsalvsgMHNLTKDESDYIFIDR 122
                 79****************775433333333.2356666777777777777543555566666667776 PP

>> Nsp1_C  Nsp1-like C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   1.3   2.5e-06    0.0076      15      41 ..      15      41 ..       3      48 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 2.5e-06
      Nsp1_C 15 lknktldelinkWtteLeeqekeFeeq 41
                   k+ld++i+ W++++++ ekeF+e 
  EFC36937.1 15 QAMKNLDSVIQSWNYDMTKREKEFQEL 41
                45799*******************975 PP

>> HetR_C  Heterocyst differentiation regulator C-terminal Hood domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.1   1.1e-05     0.033      38      59 ..       7      28 ..       2      40 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.1e-05
      HetR_C 38 dippekleqaleeldeiirewa 59
                 i +e+l+qa+++ld +i++w 
  EFC36937.1  7 QIKHEELQQAMKNLDSVIQSWN 28
                6999*****************7 PP

>> HARP  HepA-related protein (HARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.9   9.3e-05      0.28      18      35 ..      24      42 ..      10      49 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 9.3e-05
        HARP 18 ipSrnYdpktkkWnFs.le 35
                i S+nYd+++++++F+ l+
  EFC36937.1 24 IQSWNYDMTKREKEFQeLK 42
                568************7555 PP

>> ADIP  Afadin- and alpha -actinin-Binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   3.5   0.00023      0.69     110     148 ..       5      43 ..       2      47 .. 0.91
   2 ?   -0.4   0.1      0.35   1.1e+03      54      72 ..      68      86 ..      66      93 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00023
        ADIP 110 klknekeelqrlknalqqiktqyahelkkkdreiekLke 148
                 + +++ eelq   ++l+++ ++ + ++ k+++e ++Lke
  EFC36937.1   5 QQQIKHEELQQAMKNLDSVIQSWNYDMTKREKEFQELKE 43 
                 6678899*******************************8 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.35
        ADIP 54 qreslnetirkleaeierl 72
                ++e+l+++i ++++++e +
  EFC36937.1 68 MKETLSQKIIRIDYDSEED 86
                6899999999999999975 PP

>> Mst1_SARAH  C terminal SARAH domain of Mst1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.1   0.00091       2.7       6      21 ..       7      22 ..       5      26 .. 0.86
   2 ?    1.3   0.1      0.12   3.7e+02      25      35 ..      39      49 ..      32      50 .. 0.87
   3 ?   -0.0   0.5      0.32   9.5e+02      10      34 ..      70      94 ..      66      95 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00091
  Mst1_SARAH  6 flsvdeLqqrlasLDp 21
                ++  +eLqq +++LD+
  EFC36937.1  7 QIKHEELQQAMKNLDS 22
                56789**********8 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.12
  Mst1_SARAH 25 qEieelrkrYq 35
                qE++e+  +Yq
  EFC36937.1 39 QELKEVSTKYQ 49
                79999999998 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.32
  Mst1_SARAH 10 deLqqrlasLDpeMEqEieelrkrY 34
                + L q++ ++D + E++ e+ +k+Y
  EFC36937.1 70 ETLSQKIIRIDYDSEEDGEDEEKKY 94
                679999999**99999988888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1976  (0.110213); expected 358.6 (0.02)
Passed bias filter:                      944  (0.0526521); expected 358.6 (0.02)
Passed Vit filter:                        97  (0.00541023); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.44u 0.26s 00:00:00.70 Elapsed: 00:00:00.41
# Mc/sec: 899.99
//
Query:       EFC36938.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-20   73.8   4.1    2.2e-20   73.3   4.1    1.2  1  TLD       TLD


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.3   4.1   1.2e-24   2.2e-20       1     138 [.      58     211 ..      58     212 .] 0.85

  Alignments for each domain:
  == domain 1  score: 73.3 bits;  conditional E-value: 1.2e-24
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl.....spkfkvyks...tgknkaylntss.dglgfG 90 
                 ll+++s++g+  s +++k++ kg t+++ik++++ ifG++++ +w+s+++ +  ds++flfs+     + +f  +k+   + +n++ ++++  +g++fG
  EFC36938.1  58 LLFRASENGFTGSDFHSKCDAKGRTVTIIKSTNGAIFGGYAATSWTSNSS-YCFDSNCFLFSIisgsgEERFTKMKNdgiHHSNTYSIYCNPnQGPSFG 155
                 69*******************************************96666.***************99999999999999777777666666357**** PP

         TLD  91 ggqpkfsLwids..slekgtsrhs.......etfengllsg..aseerfkikdiEVWgl 138
                 gg   ++++i++  + ++++s+         +t+++  + +  a+  +f ++d EV+ l
  EFC36938.1 156 GG---HDICISNnpKAQENYSNLGhsfsltgQTYGTATIKSylAGAYNFSVEDYEVFAL 211
                 96...577777744677888887756777777777777776999*************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       574  (0.0320152); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1250.12
//
Query:       EFC36939.1  [L=486]
Description: pyruvate dehydrogenase kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-38  131.9   0.3    3.1e-38  131.1   0.3    1.4  1  BCDHK_Adom3  Mitochondrial branched-chain alpha-ketoacid dehy
    2.9e-13   50.3   0.0    6.6e-13   49.2   0.0    1.6  1  HATPase_c    Histidine kinase-, DNA gyrase B-, and HSP90-like
    8.8e-05   22.3   0.0    0.00021   21.1   0.0    1.6  1  HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like
  ------ inclusion threshold ------
       0.18   11.7   0.3       0.56   10.1   0.0    1.9  2  Sorb         Sorbin homologous domain


Domain annotation for each model (and alignments):
>> BCDHK_Adom3  Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.1   0.3     7e-42   3.1e-38       2     150 ..     150     307 ..     149     336 .. 0.92

  Alignments for each domain:
  == domain 1  score: 131.1 bits;  conditional E-value: 7e-42
  BCDHK_Adom3   2 vslrqlvqfgekpstgtllksaqflreelpirlAhrvkelenlPdglvenpsvkkvkdwYaqsfeellelpkp..eleenekftelLekikkrHddvv 97 
                  +s+ +lv+f e+ s ++l+ s+ +l eel irlA++v+ l+++P+gl+ +ps++ v+dwY++sf++l +++++  + +e+ +ft+++++i +rH++++
   EFC36939.1 150 LSVSTLVEFVENTSINSLVLSSGWLIEELRIRLAQQVQLLDEMPHGLNLMPSIRIVRDWYLTSFKQLYQIKSKprNRSEEIEFTNVIRTIYDRHNPTM 247
                  8999*****99987799*****************************************************7765458999****************** PP

  BCDHK_Adom3  98 ttlaqGvlelkekrkrk.......qidseiqsFLdrfymsRIgiRmLieqhiaLteqsks 150
                    +a Gv elke+ k++       +  s++++ Ld+fy +RIgiR L+e+h++L++q ++
   EFC36939.1 248 VSVAGGVAELKEELKKTmleyidyTNYSSLKDHLDSFYINRIGIRTLLEHHLSLHDQVEN 307
                  ***********99888789999999999****************************9876 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.2   0.0   1.5e-16   6.6e-13      10     107 ..     371     483 ..     363     486 .] 0.82

  Alignments for each domain:
  == domain 1  score: 49.2 bits;  conditional E-value: 1.5e-16
                 HHHHHHHHHHH....HS.TTTEEEEEEEEEETEEEEEEEESSSSSTTHHHTGTCS.TTCH.........HCSTCHTSTSSSHHHHHHHHHHHHTTTEEE CS
   HATPase_c  10 isnlvdNavkf....at.kageieveikaseddlvisveDnGiGipkedlkklfe.kfsq.........ddstkrggggtGlGlsivkklvelmgGeiw 93 
                 +++l+ N++++     t + + + + +++s+d+++i+++D G+Gip++d+++lf   +s+         +d+++ +  g+G+Gl +vk +++ +gGe++
  EFC36939.1 371 LIELLINSMRAvvenHTdSLPPVGILMSSSQDEVTIRISDEGKGIPRKDMPQLFSyLYSTasvrkeivnQDGKQGSVAGFGFGLPLVKLYSKYWGGEFK 469
                 55555666665443222355577899998889***********************88888********888888888********************** PP

                 EEEETTTEEEEEEE CS
   HATPase_c  94 vesepgrGttftft 107
                 ++s +g Gt+ +++
  EFC36939.1 470 LNSVSGYGTDAYLY 483
                 *********98876 PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   4.7e-08   0.00021       5      76 ..     369     453 ..     365     468 .. 0.74

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 4.7e-08
  HATPase_c_3   5 kAlaelvdNsldAdaen.......vkievnknrgktgeivieDdGkGmseeelknalrlatsskeakr.......kstslGkkGiG 76 
                  + l+el+ Ns+ A  en       v i ++  + ++ +i+i D+GkG++++++ + +++  s+ + ++       k+ s+  +G+G
   EFC36939.1 369 FQLIELLINSMRAVVENhtdslppVGILMSSSQ-DEVTIRISDEGKGIPRKDMPQLFSYLYSTASVRKeivnqdgKQGSVAGFGFG 453
                  5699********************999999975.799**************99998864444444332222232233334444444 PP

>> Sorb  Sorbin homologous domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   0.00013      0.56      14      41 ..     199     220 ..     193     225 .. 0.81
   2 ?   -3.6   0.0       2.4   1.1e+04      10      19 ..     411     418 ..     409     420 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00013
        Sorb  14 iPlalrntvedrskDWYktmFKqiHkln 41 
                 +P ++r       +DWY t FKq+ +++
  EFC36939.1 199 MP-SIRIV-----RDWYLTSFKQLYQIK 220
                 66.66665.....7**********9986 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 2.4
        Sorb  10 devGiPlalr 19 
                  ++GiP  ++
  EFC36939.1 411 EGKGIP--RK 418
                 579999..43 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       728  (0.0406046); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2821.63
//
Query:       EFC36940.1  [L=537]
Description: aminotransferase, classes I and II family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.5e-39  133.9   0.0    1.2e-38  133.2   0.0    1.3  1  Aminotran_1_2    Aminotransferase class I and II
  ------ inclusion threshold ------
      0.098   11.2   0.0       0.19   10.2   0.0    1.4  1  Cys_Met_Meta_PP  Cys/Met metabolism PLP-dependent enzyme


Domain annotation for each model (and alignments):
>> Aminotran_1_2  Aminotransferase class I and II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.2   0.0   1.3e-42   1.2e-38       2     362 ..     124     524 ..     123     525 .. 0.90

  Alignments for each domain:
  == domain 1  score: 133.2 bits;  conditional E-value: 1.3e-42
                    EEEESSSSSTTSTTSSHHHHHHHHHHHH..HHHHHTSTTST-BTTHHHHHHHHHHHHHCTCTTCHTTGGEGEEEESHHHHHHHHHHHHHHHTTT-E CS
  Aminotran_1_2   2 dvinLgsneylgdsgkptlpevakaeke..galaggtlneygpidglpeleealakflgrseklklkreaavvvgsGagaliealifllklnpgde 95 
                    +vin+g+n++lg  g   ++e  k + +  g++++g++ +yg+id++ ++e+  akf+g        +ea ++++ G++ + ++++++ k  ++d+
     EFC36940.1 124 KVINFGTNNFLGFIGDKDIHEKCKDTVReyGVGSCGPRGFYGTIDVHLDFEKLCAKFMG--------TEACILYSFGFCTVSSVIPAFSK--REDV 209
                    79***********9998888888888778******************************........9999******************9..**** PP

                    EEEEESS-THHHHHHHHTTSEEEEEEBEETTTTEE-HHHHHHHHTTHHCTTE.....TEEEEEEESS-TTT--B--HHHHHHHHHHHHHT.TEEEE CS
  Aminotran_1_2  96 ilvpdptyasyknilrlsggevvryplyseedfhldlealeealkeapegnk.....ktkvilvesphNPtGtvatleeleklldlakky.nlllf 185
                    il ++     +k+++ l++++v +++       h++++ale+  ke  +++       +++i+ve+++ + G++a+l+e+ +l   +kky +++++
     EFC36940.1 210 ILCDEACNYAIKTGCHLARSTVGYFK-------HNNVKALEDMMKEIVANDNgatpkNRRFIVVEGVYENNGDIANLKEIIAL---KKKYvGFRII 295
                    **************************.......*************9998889***99**********************999...********** PP

                    EEETTTTCBSSSSHTHHH.HGGSTTSTTEEEEEESSSTTSSGGG-EEEEEEEHHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHHHH.HHHHHHH CS
  Aminotran_1_2 186 vDeaYagfvfgsldavat.ranveeepnllivgslsKafGlaGeRvGyilgnaavvsqlrklsrpflsssllqaavaaalsdallkqs.eleemrq 279
                    +D+ Y+++v+g+++  ++ +++++  +  +++  +  +fG++G   G ++g+  +v+++r   +++++s++l++++++a+  a  k + + +    
     EFC36940.1 296 LDDSYGVGVLGKTGRGTIeHFGLDINDFEIVCVNMENSFGSVG---GVCVGSNIIVDHQRLSGAGYCFSASLPPYLSTAAIEAMNKLDtNPDSYLV 388
                    ***********775444478888877668**************...********************************999999888878888889 PP

                    HHHHHHHHHHHHHHHS......TEEEECCS.CSSEEEEEETHH..................................CHHHHHHH........... CS
  Aminotran_1_2 280 rlqkrrkelrdeLael......glkvlasq.sgmflltdlsae..................................takelskk........... 323
                     lqk+ + l + L+++       l  l ++   +f++++ + +                                  +                  
     EFC36940.1 389 PLQKNVTLLSETLNKKisfknsKLVLLHEDkCPIFHIRLADDHpakaalleakkqvdqfkskknkkqmaqasilfyeE------Rnkvqqkfkdiv 478
                    99***********999999999888888886889999999988*9*********999999999777777666666662......044444466667 PP

                    ..HHHTCTEEEEEGGGGTS......TTEEEEEC.TTS-HHHHHHHHHH CS
  Aminotran_1_2 324 ..Lleevgvyvtpgtsftv......pgrlRitv.Aglteeeleelvea 362
                       +++ gv+v+  ++ +       pg lR++v + +t++ le+ ++ 
     EFC36940.1 479 skAIDQ-GVAVVCPNYTHReitlpePG-LRLSVsSKHTKQHLEKCADV 524
                    77****.***99999999999**9555.*************9998875 PP

>> Cys_Met_Meta_PP  Cys/Met metabolism PLP-dependent enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   2.1e-05      0.19      57     181 ..     173     305 ..     168     314 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 2.1e-05
                      HHHHHHHHHT-SEEEEESSHHHHHHHHHHTTS-TTEEEEEESTSSHHHHHHHHHTHHHTTCEEEEESTTSHHHHHHHCCT........TEEEEE CS
  Cys_Met_Meta_PP  57 leeriaaLeggeaalavssGmaAiaaailallkaGdeivvsddlYggtqrllkkvlkklgievkfvdtsdleelekaike........ntklvy 142
                      +e+  a+  g+ea++++s G ++++++i a+ k  d i++++ +    +  ++   + +g  +k+ +++ le++ k i          n + + 
       EFC36940.1 173 FEKLCAKFMGTEACILYSFGFCTVSSVIPAFSKREDVILCDEACNYAIKTGCHLARSTVGY-FKHNNVKALEDMMKEIVAndngatpkNRRFIV 265
                      89999*******************************9999998866666666555544443.33344444444433332111222224889999 PP

                      EESS-TTTT----HHHHHHHHHHTT.-EEEEEGTTTHTTT CS
  Cys_Met_Meta_PP 143 lEtptnpllkvvDiekiaklakkag.vlvvvDntfaspll 181
                      +E +     +++ +++i++l kk     +++D ++  ++l
       EFC36940.1 266 VEGVYENNGDIANLKEIIALKKKYVgFRIILDDSYGVGVL 305
                      9999999999999999999999986599999999988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (537 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1290  (0.0719505); expected 358.6 (0.02)
Passed bias filter:                      806  (0.0449551); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.34s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 3078.27
//
Query:       EFC36941.1  [L=522]
Description: hypothetical protein NAEGRDRAFT_82053 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.6    8.7   5.6       0.41   10.6   2.1    1.8  2  DUF2400   Protein of unknown function (DUF2400)


Domain annotation for each model (and alignments):
>> DUF2400  Protein of unknown function (DUF2400)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.13   2.4e+03     110     110 ..     128     128 ..      38     204 .. 0.62
   2 ?   10.6   2.1   2.3e-05      0.41      41     111 ..     291     366 ..     281     403 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.13
     DUF2400 110 e 110
                  
  EFC36941.1 128 M 128
                 1 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 2.3e-05
     DUF2400  41 lelmdkspydfvleeeeekdlkelekf....kyRffnsedllallkalkelleksgsLeeaflk.....aeeeeeeleea 111
                 ++++ k+ ++ ++++++++ ++++ k+     yR+f+++dl++  k++k+l+   +s++ a++      +    ++  ++
  EFC36941.1 291 IKTTTKAAKSLFKNKQARSRFSRIAKLtgkrAYRTFKKADLKTKYKTVKSLYGGAKSIKGALTFkrnerK----PRQSNR 366
                 55566666667777777777777666435436***************************98877433331....222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1721  (0.0959897); expected 358.6 (0.02)
Passed bias filter:                      543  (0.0302861); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.52
# Mc/sec: 3030.67
//
Query:       EFC36942.1  [L=1150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-11   43.9   0.5    2.9e-11   43.9   0.5    2.1  2  PHM7_cyt  Cytosolic domain of 10TM putative phosphate transpo
    6.6e-10   39.0   4.6    6.6e-10   39.0   4.6    4.0  4  RSN1_TM   Late exocytosis, associated with Golgi transport
      1e-08   34.9  24.3      1e-08   34.9  24.3    4.1  2  RSN1_7TM  Calcium-dependent channel, 7TM region, putative pho
  ------ inclusion threshold ------
       0.15   12.6   2.6       0.34   11.5   2.6    1.6  1  PSI       Plexin repeat


Domain annotation for each model (and alignments):
>> PHM7_cyt  Cytosolic domain of 10TM putative phosphate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.9   0.5   6.4e-15   2.9e-11       2     141 ..     538     668 ..     537     719 .. 0.85
   2 ?   -2.2   0.9      0.91   4.1e+03      50     115 ..    1032    1092 ..    1025    1101 .. 0.53

  Alignments for each domain:
  == domain 1  score: 43.9 bits;  conditional E-value: 6.4e-15
    PHM7_cyt   2 rTvlvtgiPkelrseeklkeffeelypgkvvesvqivrdvkkldklveerekavrkleaalskykkngkklpkkrpthklgflglkligkkvdaidyyr 100
                 +Tv+++++ k l++++ l + ++ ++ ++ + +++i+ d++k++ l ++ e +  k    ls +++n + +      + ++ l+ kl+ +     +yy+
  EFC36942.1 538 YTVMISNVDKTLKDKDILLRELRAMFGDNSIVDCHICFDYSKINALEKDIEILKTK----LSLLDENRNVT-----INYIKSLHSKLV-RNMSLQEYYT 626
                 8**************99999999999999999***************998864444....44555665544.....445566666664.678889**** PP

    PHM7_cyt 101 ekleeldeeieeerekvkkkplgaaFvtfesersaaavak.q 141
                 +++e+ + +++e++++ +   +g aF tf+s ++a++v++ +
  EFC36942.1 627 SEIEKSETKLSELKKENEICGTGFAFATFSSLKMAQQVCDeY 668
                 ***************998889*****************9752 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.91
    PHM7_cyt   50 erekavrkleaalskykkngkklpkkr..........pthklgflglkligkkvdaidyyrekleeldeeieeere 115 
                  er+ ++ +l++  +++ k        +          pt+ +         +  da +y r+++ee  + i+ e++
  EFC36942.1 1032 ERDAIIISLKERSEQSHK--------KediveeldttPTNNTPT-------NIQDASEYTRKNIEEDHDFIKLEQN 1092
                  444444444433333333........223333333335555432.......2358888888888887777777776 PP

>> RSN1_TM  Late exocytosis, associated with Golgi transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   4.6   1.5e-13   6.6e-10      57     145 ..     423     509 ..     406     519 .. 0.81
   2 ?   -0.0   0.3      0.15   6.5e+02       3      24 ..     732     753 ..     730     798 .. 0.76
   3 ?   -5.0   1.9         4   1.8e+04      11      21 ..     942     952 ..     924     965 .. 0.57
   4 ?   -0.2   1.1      0.17   7.5e+02      86     104 ..     982    1000 ..     974    1032 .. 0.88

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 1.5e-13
     RSN1_TM  57 pallkisdeeilekaGLDayvflrflkmlikiflvlavlalivLlPvnatggegedskesksgldklsisnvs.egsnrlwahvvvayif 145
                 ++l+++sd+ei++k+G D y fl f k+li +++v+  +++i+LlP+++ +++ + s    +++++ +i+ ++ ++s   ++ +++  ++
  EFC36942.1 423 ISLFSTSDSEIVRKCGTDVYYFLWFQKYLILFVTVCGAISMIILLPIYILSKQYDYSF---RDFSMTTIASINvKTSILTILFFIMNGVI 509
                 6799*********************************************999998655...37888888888734444455555554444 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.15
     RSN1_TM   3 ltslvinlvlalvflllFlilR 24 
                 lt++v n++l+++++++++il 
  EFC36942.1 732 LTNIVSNALLTFILIIAYAILI 753
                 7899999999999999999984 PP

  == domain 3  score: -5.0 bits;  conditional E-value: 4
     RSN1_TM  11 vlalvflllFl 21 
                  +a+v++++F 
  EFC36942.1 942 YIAVVLYFIFT 952
                 33333333333 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.17
     RSN1_TM   86 ikiflvlavlalivLlPvn 104 
                  i ++++l+ + +ivL+Pv 
  EFC36942.1  982 IGFCFILSPFYIIVLMPVL 1000
                  668999999********96 PP

>> RSN1_7TM  Calcium-dependent channel, 7TM region, putative phosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.2     0.078   3.5e+02      83     117 ..     428     464 ..     416     475 .. 0.78
   2 !   34.9  24.3   2.2e-12     1e-08      57     273 ..     793     996 ..     730     997 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.078
    RSN1_7TM  83 lsrselelsvvskyfaFlvvn..vFlvftlagtalsl 117
                 +s se+ +++ + +++Fl ++  ++l++t+ g+++ +
  EFC36942.1 428 TSDSEIVRKCGTDVYYFLWFQkyLILFVTVCGAISMI 464
                 6889999999*********994334556666666554 PP

  == domain 2  score: 34.9 bits;  conditional E-value: 2.2e-12
    RSN1_7TM  57 lPtlllslllallpiilrllsklqGalsrselelsvvskyfaFlvvnvFlvftlagtalslleeiidnptsipkllaeslp..kasnFfityillqgla 153
                 l + + sl++  + +i++ l  ++   +r ++ +s++++  +F++++ ++++     a+++ +++          + +slp  ++  +f+++i ++ + 
  EFC36942.1 793 LTPEIISLINESIKPIVEKLVAWEKPKTRMHERKSILRRTTYFFIMSTIIFPY----AWTYYKSVWR--------IFKSLPpfNNEIYFFNFIGIELI- 878
                 66778899999999*************************99999988776654....5666555555........3334443467789*******977. PP

    RSN1_7TM 154 gaaleLlqlv.klilflikrkflsktprdlaerytkppsfdygteypkvllifvialiYsviaPlilpfaliyfllgylvykyqllyvydtkyesgGkl 251
                 +++l L+  + +l + +   ++l    r+      + p+fdy  ey+  +++++++l Y +  Pl+ + +++yf++ y+v ky ++y y+ + es+Gk+
  EFC36942.1 879 ITTLVLACTSkGLDMIFTSISMLYDYWRTG---ELHRPKFDYEAEYSIKITLLIMCLFYGTCMPLVYIAVVLYFIFTYIVEKYLIMYWYERSIESDGKI 974
                 666666655505555555555664443333...346899************************************************************ PP

    RSN1_7TM 252 wpralnrllvglvlfqllligl 273
                  +++  ++ ++ +l+ + +i l
  EFC36942.1 975 LNTVAENIGFCFILSPFYIIVL 996
                 ************9998877765 PP

>> PSI  Plexin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   2.6   7.6e-05      0.34       6      40 ..      41      77 ..      37      88 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 7.6e-05
                SSHHHHHHSTCTTEEEETTTTEEEE.CTTS.TTTTSS CS
         PSI  6 ttCssCleardpgCgWCsdegrCie.eskc.esspeg 40
                t+C +C+ +   g  WC+ e+rC++ +s+c +s +++
  EFC36942.1 41 TNCLDCTDSAIGGGIWCAMENRCVSsASECySSFYSK 77
                89******9989999**********888886444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1172  (0.065369); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.95u 0.32s 00:00:01.27 Elapsed: 00:00:00.57
# Mc/sec: 6063.87
//
Query:       EFC36943.1  [L=1075]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.8e-13   50.3   0.6    6.9e-13   49.0   0.0    2.0  2  Dynamin_N    Dynamin family
    5.8e-05   23.1   0.2    0.00039   20.4   0.0    2.4  2  RsgA_GTPase  RsgA GTPase
    0.00028   21.4   0.2     0.0015   19.1   0.0    2.3  2  ABC_tran     ABC transporter
    0.00043   20.3   0.0      0.004   17.2   0.0    2.6  2  MMR_HSR1     50S ribosome-binding GTPase
  ------ inclusion threshold ------
      0.028   15.0   0.1       0.15   12.6   0.1    2.4  1  LPD25        Large polyvalent protein associated domain 25
       0.18   12.0   1.5        7.7    6.7   0.2    2.6  2  YqaJ         YqaJ-like viral recombinase domain
        4.2    7.4   5.9        1.9    8.5   2.6    2.1  2  SPATA1_C     Spermatogenesis-associated C-terminus


Domain annotation for each model (and alignments):
>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.0   0.0   2.7e-16   6.9e-13       1     137 [.     118     279 ..     118     304 .. 0.77
   2 ?   -3.5   0.2       3.6   9.3e+03      59      76 ..     593     610 ..     563     637 .. 0.54

  Alignments for each domain:
  == domain 1  score: 49.0 bits;  conditional E-value: 2.7e-16
                 EEEEEBTTTTHHHHHHHHHTS--S---S..SS---S-EEEEECCT---C.................CS...SSEEEE...T-EB--CHHHHHHHHHHHH CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlgedilprgp..nptTrrplelqlgeeeeas.................eravkeelkek...ekkledfsevreeiekete 77 
                 +++vGs   GKSS++n ++ge+ilp g   +++Tr +lel++ ++ e+                  +++++++++ek   ++  +++ ++re ++k+++
  EFC36943.1 118 VTFVGSSGLGKSSLINMIIGEPILPCGDdiGHITRSILELSYAKNYEVIvqycneeefnkrralapKEFASITYEEKkdsHETVNSVGDIREFLDKQFR 216
                 679**********************7651168**********666665555555555555666777778888888886667777788888888889988 PP

                 HHHT.SSSS--SS-EEEEEEETTS-SEEEEE---B-SSSGTTS..HHHHHHHSTTEEEEEEEE CS
   Dynamin_N  78 kiag.ankgiskkvillkilsllvkgltlvDlPGldsvnkrdq..elvkeyikkadiilavts 137
                 + ++  + +++k++ +l ++ l++ +lt+ D+PG++s    +   + +++ i+k ++il+ ++
  EFC36943.1 217 EMKDlDLIKVDKILGKLPVQLLQDFNLTIRDTPGYKSGTFSRIyqHFIEKSITKTNMILFFSE 279
                 8887677788888999999999999************877765569******88888888764 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 3.6
                 T-EB--CHHHHHHHHHHH CS
   Dynamin_N  59 ekkledfsevreeieket 76 
                 +++l++ +++++ei+  +
  EFC36943.1 593 NTHLKQHTNIKNEIKTNM 610
                 333333333333333333 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   1.5e-07   0.00039      82     122 ..      99     138 ..      52     160 .. 0.79
   2 ?   -1.7   0.0      0.93   2.4e+03      39     100 ..     759     817 ..     751     822 .. 0.73

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.5e-07
                  --TTTHTTHHHHHHHCTTSEEEEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase  82 vsaktkegleelkellkdktsvlvGqSGvGKStLinallpe 122
                   +++ ++ ++++++++  ++ ++vG+SG GKS+Lin++++e
   EFC36943.1  99 AEENLNSCIDKINQVIGVDV-TFVGSSGLGKSSLINMIIGE 138
                  44455567778877776654.69***************987 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.93
                  HHHHHHTT-EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTTS CS
  RsgA_GTPase  39 LvlaeekgiepvivlnKiDlleeeeeleelkeelealgyevllvsaktkegleelkellkdk 100
                  L++ +++ i p++++ K ++ ++   +++l++++++ ++ v++  ++  ++++++++l+kd+
   EFC36943.1 759 LFTGNDEFIAPIMIFAKDEIKQNLI-CNTLSKNINSDNFLVFIFCQE--SNWSSISKLVKDN 817
                  5566677899999999998888888.999999999888877765444..5666666666665 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   5.8e-07    0.0015      14      93 ..     118     205 ..     113     249 .. 0.62
   2 ?   -2.0   0.2       1.9   4.9e+03      66      95 ..     591     649 ..     551     674 .. 0.49

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 5.8e-07
                 EEEEESTTSSHHHHHHHHTTSS--....SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH......HHHTCHHHHHHHST CS
                 xxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxx RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkp....teGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren......esdeeiekalsklg 93 
                 v +vG++G GKS+L+++++g+       + G+i+    +l++   + ++  ++++ +e++ +++  + ++      e++++ ++ ++++g
  EFC36943.1 118 VTFVGSSGLGKSSLINMIIGEPILpcgdDIGHITRSILELSY--AKNYEVIVQYCNEEEFNKRRALAPKEfasityEEKKDSHETVNSVG 205
                 789******************988444455555333333333..5555555555555544444332222245555533333444444333 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.9
                 SS--S-TTSBHHHH.............................HHHTCHHHHHHHSTTG CS
                 xxxxxxxxxxxxxx.............................xxxxxxxxxxxxxxxx RF
    ABC_tran  66 qepqlfpeltvren.............................esdeeiekalsklglk 95 
                 q++++ +++t+ +n                             e + +++++ ++++ +
  EFC36943.1 591 QKNTHLKQHTNIKNeiktnmivltnffnslfdknnnakvnlivETKFKLTELFEHYKHE 649
                 33222222222222233334555555555555544455555553333344444444333 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   1.5e-06     0.004       2      58 ..     118     252 ..     117     287 .. 0.74
   2 ?   -2.2   0.0       1.6   4.1e+03      67     100 ..     463     493 ..     455     508 .. 0.69

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.5e-06
                 EEEEESTTSSHHHHHHHHHTS.TEEE.SSSTTSSSSEEEEEEEETTEE................................................... CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltge.kaiv.sdkpgtTrdinegrvklkgke................................................... 47 
                 v +vG +  GKS+Lin ++ge       d+   Tr i e  ++++  e                                                   
  EFC36943.1 118 VTFVGSSGLGKSSLINMIIGEpILPCgDDIGHITRSILELSYAKN-YEvivqycneeefnkrralapkefasityeekkdshetvnsvgdirefldkqf 215
                 899*****************9744443788889999988887733.23455566666777777888888888888888888888888888888888888 PP

                 ...........................EEEEECGGCSS CS
    MMR_HSR1  48 ...........................ielvDtpGlie 58 
                                            +++ DtpG ++
  EFC36943.1 216 remkdldlikvdkilgklpvqllqdfnLTIRDTPG-YK 252
                 88888888888888888888888888888889998.75 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.6
                 HHHHHHHHCTSEEEEEEETTTTCSHHHHHHHHHH CS
    MMR_HSR1  67 gkaflaleeadlillvvdaseeklkpldeeleel 100
                 ++ +l+++e dl +++ d++++ +++    +ee+
  EFC36943.1 463 TQYYLRKIENDLCAYMYDITQK-FSD--IAIEEY 493
                 5667778888********9944.533..344444 PP

>> LPD25  Large polyvalent protein associated domain 25
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1     6e-05      0.15       2      43 ..     159     200 ..     158     266 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6e-05
       LPD25   2 kidepyvliewsespefeegellsfaeanellekldekqyke 43 
                 ++++++v +++++++ef++ + l  +e+++++++  ++ ++ 
  EFC36943.1 159 YAKNYEVIVQYCNEEEFNKRRALAPKEFASITYEEKKDSHET 200
                 5789******************************99988876 PP

>> YqaJ  YqaJ-like viral recombinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.1     0.027        70      80     141 ..     409     473 ..     394     477 .. 0.76
   2 ?    6.7   0.2     0.003       7.7      59     130 ..     584     655 ..     571     669 .. 0.74

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.027
        YqaJ  80 fespsdkflgaspDgiishasid....alkrrllEikspfealyvstklgrqe.eipeeYmcQiqgq 141
                 fes++++fl   + g++ ++  +      +++++Ei+++  +l +s + ++ + +  ++Y+  i+  
  EFC36943.1 409 FESQKQDFLENFMHGLVEEQ--GrilhSERKNIIEITCALVPLLMSICVNNFSeKQTQYYLRKIEND 473
                 55567777777777777433..2345556789*****************999977788888877765 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.003
        YqaJ  59 plaraeyelatgdkvrdsgglfespsdkflgaspDgiishasidalkrrllEikspfealyvstklgrqe.ei 130
                 p+ r+e+++ t  k +  +  +e + + ++++++     +++++a+ + ++E+k   + l+ ++k + q+ e+
  EFC36943.1 584 PIFRKEFQKNTHLKQHT-NIKNEIKTNMIVLTNFFNSLFDKNNNAKVNLIVETKFKLTELFEHYKHESQDdEY 655
                 67788888888866666.555555567777777655555666677999*****************97776543 PP

>> SPATA1_C  Spermatogenesis-associated C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       2.3     6e+03      18      35 ..      48      65 ..      45      74 .. 0.79
   2 ?    8.5   2.6   0.00074       1.9      56     134 ..     556     638 ..     537     642 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.3
    SPATA1_C 18 eellrkakelleqnkqkr 35
                 el++k k l++ n+ + 
  EFC36943.1 48 SELMKKVKVLFTSNRDEC 65
                699999999999888655 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00074
    SPATA1_C  56 asLeeelkkLrqelellykkllaqlka....rdnkkkeknvakseelkneliiqiiaaqheidelkrkledakmklvaElklR 134
                 + +e +l++ ++++ ++ k+l  +l +    r++ +k+++ ++++++kne   ++i +++  + l +k ++ak++l+ E+k +
  EFC36943.1 556 SNIEQVLTSCKRNITTVCKQLYENLTSnpifRKEFQKNTHLKQHTNIKNEIKTNMIVLTNFFNSLFDKNNNAKVNLIVETKFK 638
                 4679999999999999999999999997777777667777777778*********************************9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1075 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1435  (0.0800379); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 6100.14
//
Query:       EFC36944.1  [L=304]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.024   14.4   2.0      0.026   14.3   0.1    2.1  2  DUF713      Protein of unknown function (DUF713)
       0.12   12.8   9.3       0.15   12.4   0.2    3.3  3  Syntaxin_2  Syntaxin-like protein
        1.1    9.5   5.8          5    7.3   0.3    3.1  3  IFT20       Intraflagellar transport complex B, subunit 20


Domain annotation for each model (and alignments):
>> DUF713  Protein of unknown function (DUF713)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.1   4.3e-06     0.026      67     138 ..      47     149 ..      29     202 .. 0.81
   2 ?   -1.9   0.1       0.4   2.4e+03     100     111 ..     274     285 ..     269     303 .. 0.49

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 4.3e-06
      DUF713  67 klekedleelqselsnLakkvlsaynkLeeafeklkelsekfedkiFlkvL............................qksisdvatkllei....le 133
                 +l++++l+ + + l  L++ + +  ++L++ +e l+e++e+ ++ +Fl  +                            + +i+d+ tkl++i    l+
  EFC36944.1  47 ELKRVSLDSI-NKLGTLKNAMENGIKELSNLWEILTEMDEEQPGSLFLMDFeedgeettpafsmsnsqtssnkvnlraqRIQICDQITKLINIestlLN 144
                 4444444444.57899*********************************99*********************999999877888888888888544433 PP

      DUF713 134 vldel 138
                 ++++ 
  EFC36944.1 145 IIESH 149
                 33332 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.4
      DUF713 100 klkelsekfedk 111
                 kl++l++kf+ k
  EFC36944.1 274 KLEKLNKKFQRK 285
                 444444444332 PP

>> Syntaxin_2  Syntaxin-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.051     3e+02      27      59 ..      44      76 ..      30      86 .. 0.83
   2 ?    1.4   2.2     0.067     4e+02      23      62 ..     113     152 ..     108     199 .. 0.83
   3 ?   12.4   0.2   2.5e-05      0.15      67     100 ..     270     303 ..     249     304 .] 0.83

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.051
  Syntaxin_2 27 dteelreklhelieeinelikktnellkklsql 59
                + +el++   ++i+++ +l +++++ +k+ls+l
  EFC36944.1 44 QYTELKRVSLDSINKLGTLKNAMENGIKELSNL 76
                567888888899999999999999999999987 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.067
  Syntaxin_2  23 gtkkdteelreklhelieeinelikktnellkklsqldns 62 
                 +t+ +  +lr +  +++++i++li+  + ll+ +++ +n 
  EFC36944.1 113 QTSSNKVNLRAQRIQICDQITKLINIESTLLNIIESHQNM 152
                 677888999*999**********99988888877776665 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 2.5e-05
  Syntaxin_2  67 qqklqkekLkkdfkealqeFqkiqrqyaekekqi 100
                 ++ ++ ekL+k+f++ l+eF+ +  q+ + ++q+
  EFC36944.1 270 REFIKLEKLNKKFQRKLNEFEGVIVQFVQMKQQY 303
                 677899***********************99997 PP

>> IFT20  Intraflagellar transport complex B, subunit 20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.042   2.5e+02      15      52 ..      39      76 ..      35      84 .. 0.86
   2 ?    1.3   0.4      0.06   3.6e+02      16      58 ..     113     155 ..     107     157 .. 0.72
   3 ?    7.3   0.3   0.00084         5      21      51 ..     272     302 ..     265     304 .] 0.87

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.042
       IFT20 15 pevaeeteelkeeckeFvkkinefqklvkelievleel 52
                 e++e+ +elk  + + ++k+ ++++++++ i+ l++l
  EFC36944.1 39 AESFEQYTELKRVSLDSINKLGTLKNAMENGIKELSNL 76
                5789999999999999999*999999999999888776 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.06
       IFT20  16 evaeeteelkeeckeFvkkinefqklvkelievleelakkvek 58 
                 ++++++ +l+ + ++ +++i+++ ++ ++l++++e+  + +e+
  EFC36944.1 113 QTSSNKVNLRAQRIQICDQITKLINIESTLLNIIESHQNMLEN 155
                 5566677778888888888888888888888888877776665 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.00084
       IFT20  21 teelkeeckeFvkkinefqklvkelievlee 51 
                   +l++ +k+F  k+nef+ ++ +++++ ++
  EFC36944.1 272 FIKLEKLNKKFQRKLNEFEGVIVQFVQMKQQ 302
                 56899999******************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       908  (0.0506442); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1984.82
//
Query:       EFC36945.1  [L=455]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-10   40.1   6.8    4.4e-10   39.2   6.8    1.4  1  ZZ        Zinc finger, ZZ type
    2.5e-06   27.3   0.2    4.5e-06   26.5   0.2    1.3  1  PB1       PB1 domain
  ------ inclusion threshold ------
      0.013   14.4   0.0      0.019   13.8   0.0    1.2  1  DUF1015   Protein of unknown function (DUF1015)
       0.14   12.3   0.1       0.35   11.0   0.1    1.6  1  DUF4761   Domain of unknown function (DUF4761)
       0.77    9.4   8.0          6    6.5   1.5    3.1  3  GET2      GET complex subunit GET2


Domain annotation for each model (and alignments):
>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.2   6.8   1.2e-13   4.4e-10       2      43 ..     273     313 ..     272     314 .. 0.92

  Alignments for each domain:
  == domain 1  score: 39.2 bits;  conditional E-value: 1.2e-13
                 SS-EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH.H---S CS
          ZZ   2 hkkytCdgCseapligvRyhclrcsdYDLCqsCfsthkagkh 43 
                 h++  CdgC++  + g R+ c+ c d+D Cq+Cf t ka +h
  EFC36945.1 273 HFGIVCDGCGKRNFTGSRWNCADCGDFDFCQECFET-KANDH 313
                 77889*******************************.77766 PP

>> PB1  PB1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.5   0.2   1.3e-09   4.5e-06      18      69 ..      45      96 ..      31     108 .. 0.83

  Alignments for each domain:
  == domain 1  score: 26.5 bits;  conditional E-value: 1.3e-09
                EGSSS-HHHHHHHHHHHHTSTCCSEEEEEEETTSSEEEESSHHHHHHHHHHH CS
         PB1 18 vssnisfeeLrakvekrfklsdedvklkYpdedgdlVtitsDeDLeealeea 69
                 +s+i+fee+++k++ +   +d ++kl Y d+ +d+V+++ +eD +   +  
  EFC36945.1 45 DQSGITFEEFVQKLKTKSIVTDTNFKLFYLDDQNDWVSLSDEEDWKILNSIL 96
                57899************9999***********************87665555 PP

>> DUF1015  Protein of unknown function (DUF1015)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   5.4e-06     0.019     257     323 ..      39     107 ..      33     120 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 5.4e-06
     DUF1015 257 ihRvvkdlnglseeelleklaeafevap...fglylkdgkwyklltlkdkavrsLdvsvlqelllepilg 323
                 +hR++ d +g++ ee+++kl+++  v++     +yl+d++ +  l+ ++ +++ L+  +++e++++ +++
  EFC36945.1  39 VHRLILDQSGITFEEFVQKLKTKSIVTDtnfKLFYLDDQNDWVSLSDEE-DWKILNSILASETVIKIVCQ 107
                 7*********************998833444355666665555555344.7***********99997765 PP

>> DUF4761  Domain of unknown function (DUF4761)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   9.7e-05      0.35      42      84 ..     266     308 ..     257     319 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 9.7e-05
     DUF4761  42 ehtwliekagivvhkcprnpltgnrifalssgdnqfgqdftly 84 
                 + ++ i + giv   c +  +tg r  +  +gd +f q+   +
  EFC36945.1 266 NGSFNIPHFGIVCDGCGKRNFTGSRWNCADCGDFDFCQECFET 308
                 567788899****************************986555 PP

>> GET2  GET complex subunit GET2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.021        75     127     152 ..     113     139 ..      90     155 .. 0.71
   2 ?    6.5   1.5    0.0017         6     116     166 ..     187     232 ..     168     249 .. 0.57
   3 ?    1.6   1.0     0.052   1.9e+02     107     136 ..     330     359 ..     302     435 .. 0.61

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.021
        GET2 127 sqdaesstP.dlfsqllkmmkqgeggs 152
                 s+++++  P d+fs+++k+++  +g +
  EFC36945.1 113 SETDNNDSPkDPFSEIFKNFNLHGGRR 139
                 2333333455**********9988873 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0017
        GET2 116 lqqqqqgnsensqdaesstPdlfsqllkmmkqgeggsakseeetssspeea 166
                 +     +n +n+q+++ + P  +s+ll+++  g +++++++e+  +++e++
  EFC36945.1 187 F-----NNPNNGQQQQGANPFDLSSLLNNLFPGAAQQQQTQENAPQQEESK 232
                 3.....345666667777884445588888888888333333333333222 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.052
        GET2 107 qldqllkqllqqqqqgnsensqdaesstPd 136
                  l ++ k++ ++q+++ +++  ++++s+P+
  EFC36945.1 330 FLSNFVKKMEGNQSESAQQETPTQQDSVPE 359
                 233333333333333333333333333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (455 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1178  (0.0657036); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.28s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2788.67
//
Query:       EFC36946.1  [L=111]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.7e-06   26.7   0.1    1.2e-05   25.6   0.1    1.7  1  Acylphosphatase  Acylphosphatase


Domain annotation for each model (and alignments):
>> Acylphosphatase  Acylphosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.1   6.9e-10   1.2e-05       3      64 ..       9      72 ..       7     103 .. 0.83

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 6.9e-10
  Acylphosphatase  3 llvtGrVQgvgFRkfvrrlAkelglkGyvrNlsdg..sVeivaegeeekvekfleelksgppk....a 64
                     ++ +G+ Qgv+FR+++     ++g+kG + N++++  +V i +egee  + ++ ++l + +p     a
       EFC36946.1  9 YQAKGKCQGVMFRQTII----RFGVKGGASNDKKDkdCVWITMEGEETIITELASKLINTKPLnswgA 72
                     5789**********996....68********9988889*****************9998777645554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       522  (0.0291148); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.35s 00:00:00.87 Elapsed: 00:00:00.55
# Mc/sec: 606.61
//
Query:       EFC36947.1  [L=404]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (404 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       958  (0.053433); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 2394.18
//
Query:       EFC36948.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.1e-67  225.7   0.1    7.2e-67  225.5   0.1    1.0  1  Pkinase         Protein kinase domain
    2.3e-18   66.5   0.0    3.5e-18   65.8   0.0    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
    7.6e-09   35.8   0.0    1.1e-06   28.8   0.0    2.4  3  APH             Phosphotransferase enzyme family
     0.0072   15.2   0.1      0.021   13.6   0.0    1.7  2  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.016   14.8   0.1      0.039   13.5   0.1    1.7  1  Choline_kinase  Choline/ethanolamine kinase
      0.023   14.1   0.0       0.04   13.3   0.0    1.4  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
       0.13   11.6   0.1       0.62    9.3   0.0    1.9  2  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  225.5   0.1   2.8e-70   7.2e-67       1     264 []      34     321 ..      34     321 .. 0.92

  Alignments for each domain:
  == domain 1  score: 225.5 bits;  conditional E-value: 2.8e-70
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHHHHSS-- CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee..kdelylvleyveggeladllerkgsls 96 
                 ye ++k+G+G++++V++++++et++   +K++k  k+kk k     rEikil++l    niv+l++v+++  +++  lv+e v+++++  l+    +++
  EFC36948.1  34 YEIVRKVGRGKYSEVFEGINAETNERCIIKVLKPVKKKKIK-----REIKILQNLCgGTNIVKLLDVVRDpeSKTPSLVMENVDNTDFRYLYP---TFT 124
                 7899*****************************99988855.....7********99*************5455566*********9999997...6** PP

                 HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHHHHHS CS
     Pkinase  97 eeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelessskltsfvgtseYlAPEvl.keneyskkvDvWslGvilyelltg 193
                 + +++++++++l++l+++Hs+gi+HrD+Kp+N++id ++++l+++D+Gla+ ++ +++++ +v+++++  PE+l + +ey+ + D+WslG++++ ++++
  EFC36948.1 125 DFDIRFYMYELLKALDFCHSMGIMHRDIKPHNVMIDhKQKKLRVIDWGLAEFYHPGQEYNVRVASRYFKGPELLvDFREYDYSLDMWSLGCMFAGMIFR 223
                 ************************************77777*********************************888********************** PP

                 S-STTTSSHHHHHHHHHHTHHHHHHHCTSHH....HHHTTS................................-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 194 kppfsgekgkekvekeldqlekilkilgetke.klpeasei................................seeakdllkkllkkdpkkRltaeell 259
                 k+pf   +g++    ++dql+ki+k+lg++++ ++  +++i                                +eea+d+l+kll++d+k+R+ta+e++
  EFC36948.1 224 KEPFF--HGRD----NYDQLVKIAKVLGTEELyDYLDRYSItlsahyegilsrnryprkpwstfvnkenaqlaNEEAIDFLDKLLRYDHKQRMTAKEAM 316
                 *****..4444....899*********96544144444444999999**************************************************** PP

                 TSGGG CS
     Pkinase 260 qhpyl 264
                 qhpy+
  EFC36948.1 317 QHPYI 321
                 ***97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.8   0.0   1.4e-21   3.5e-18       3     200 ..      36     222 ..      34     248 .. 0.84

  Alignments for each domain:
  == domain 1  score: 65.8 bits;  conditional E-value: 1.4e-21
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHTCT CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvct..keepllivteyvkgGdLlkfLrkkek 97 
                  + +k+G+G++++V+eg       ++++++++K+lk  +++    ++ +e+ki+++l    nivkll v+   ++++  +v+e v++ d++ +L  +  
   EFC36948.1  36 IVRKVGRGKYSEVFEGINA----ETNERCIIKVLKPVKKK----KIKREIKILQNLcGGTNIVKLLDVVRdpESKTPSLVMENVDNTDFR-YLYPT-- 122
                  6799************999....89999******776555....599***********************8878889***********96.77766.. PP

                  TTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.EEHHHHHHHHHH CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.ftsksDvWsfGv 193
                    +t  d+  +++++ k++++ +s+ ++Hrd+   Nv++++ +k+ ++ D GLa+  +  +ey+++  ++    +  pE l + + +  + D+Ws G 
   EFC36948.1 123 --FTDFDIRFYMYELLKALDFCHSMGIMHRDIKPHNVMIDHkQKKLRVIDWGLAEFYHPGQEYNVRVASR---YFKGPELLVDFReYDYSLDMWSLGC 215
                  ..788888999****************************983569***********98888776665443...4679**987654499999******9 PP

                  HHHHHHT CS
  Pkinase_Tyr 194 llwEift 200
                  +   ++ 
   EFC36948.1 216 MFAGMIF 222
                  8776655 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.013        34       3      81 ..      38     115 ..      36     123 .. 0.75
   2 !   28.8   0.0   4.3e-10   1.1e-06     165     209 ..     144     187 ..     127     206 .. 0.77
   3 ?   -3.1   0.0       2.3   5.8e+03      90     109 ..     286     305 ..     235     320 .. 0.55

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.013
                 EEE--.SSCEEEEEEETT..--EEEEEE-TTS-HHHHHHHHHHHHHHH.HTT-B--B-CTTBS-EEETTEEEEEEE----EE CS
         APH   3 relsggasnrtylvttpa..gryvlrrnpparaaeeirrevallrlLa.kagvpvPevlagdtddeeigllfalieyvpgrs 81 
                 r ++ g ++ +++   ++   r + ++  p   + +i re ++l++L  ++++   ++l+    d e+ ++++++e v+ ++
  EFC36948.1  38 RKVGRGKYSEVFEGINAEtnERCIIKVLKPV-KKKKIKREIKILQNLCgGTNI--VKLLDVV-RDPESKTPSLVMENVDNTD 115
                 667777777777766555334999*******.***************955555..4555533.3666666999999998776 PP

  == domain 2  score: 28.8 bits;  conditional E-value: 4.3e-10
                 -EEEE-SS-SGGGEEEC..TTEEEEE---TT-EEEECCHHHHCCH CS
         APH 165 ptvllHgDlhpgNllvdpddgrvtGviDfedaglgpplyDlavll 209
                 +++++H+D++p+N+++d  + ++  viD+++a   +p ++  v +
  EFC36948.1 144 SMGIMHRDIKPHNVMIDHKQKKL-RVIDWGLAEFYHPGQEYNVRV 187
                 689**************666665.7************99985544 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.3
                 HHHHHHHHHHHHHCCHHCH. CS
         APH  90 qlpellealgeflaalhqvd 109
                  ++ + e++++fl +l + d
  EFC36948.1 286 NAQLANEEAIDFLDKLLRYD 305
                 23333334444444444444 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.33   8.4e+02     155     205 ..      43      92 ..      36     102 .. 0.74
   2 !   13.6   0.0   8.3e-06     0.021     325     363 ..     144     178 ..     133     209 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.33
  Pkinase_fungal 155 gRgTtcwrarkegergkeyvvKdsWrdaerk..sEaelLkkaeergvegvarl 205
                     g+   ++++ + +++ +++++K     +++k  +E ++L++    g +++++l
      EFC36948.1  43 GKYSEVFEGINAETN-ERCIIKVLKPVKKKKikREIKILQNL--CGGTNIVKL 92 
                     444667777776555.68999998776666556999999999..888888876 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 8.3e-06
  Pkinase_fungal 325 kagiLHrDiSenNilitdskkegerkglLiDLDlakels 363
                       gi+HrDi  +N++i      +++k  +iD  la  ++
      EFC36948.1 144 SMGIMHRDIKPHNVMIDH----KQKKLRVIDWGLAEFYH 178
                     789*************93....45566677776666655 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   1.5e-05     0.039     143     174 ..     143     174 ..     106     182 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.5e-05
                     G-EEEE-S--SGGGEEE.-CTTEEEE--GTT- CS
  Choline_kinase 143 spvvfcHnDlqegNillnkeekklvlIDFEYa 174
                     +++   H D+ ++N++ ++++kkl +ID+  a
      EFC36948.1 143 HSMGIMHRDIKPHNVMIDHKQKKLRVIDWGLA 174
                     44666789*********************655 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.5e-05      0.04     135     165 ..     143     170 ..      95     182 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.5e-05
         Kdo 135 hragvnHadlyaknillqqeeeeeaeiwliD 165
                 h++g++H+d+ ++n++++ ++    ++ +iD
  EFC36948.1 143 HSMGIMHRDIKPHNVMIDHKQ---KKLRVID 170
                 9*****************998...8888998 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.26   6.8e+02      18      57 ..      38      78 ..      24      83 .. 0.73
   2 ?    9.3   0.0   0.00024      0.62     161     241 ..     143     218 ..     131     237 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.26
  Kinase-like 18 ellkkgdrsvvfevkdqetgeplavkvfllps.easkkdle 57
                   +++g+ s vfe  + et+e   +kv    + +  k++++
   EFC36948.1 38 RKVGRGKYSEVFEGINAETNERCIIKVLKPVKkKKIKREIK 78
                 4467888999999999******9999976544366666666 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00024
  Kinase-like 161 qakglvhgkftvdnllldek...gglmlggftaLvragtkvvlsevekgfaPpEllgsrggytrknktkmthkldaWqlGlviy 241
                  ++ g++h +++++n++ d+k    +++  g+ + +  g+++ +    + f+ pEll     +++     + ++ld W lG    
   EFC36948.1 143 HSMGIMHRDIKPHNVMIDHKqkkLRVIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD---FRE-----YDYSLDMWSLGCMFA 218
                  789**************975211566777899**********99999*********99...444.....88899****998655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2133.92
//
Query:       EFC36949.1  [L=947]
Description: proline-rich SH3 domain protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (947 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1514  (0.0844442); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.02u 0.32s 00:00:01.34 Elapsed: 00:00:00.57
# Mc/sec: 5001.41
//
Query:       EFC36950.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       562  (0.0313459); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1555.54
//
Query:       EFC36951.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-56  191.8   0.0    2.2e-56  191.1   0.0    1.3  1  Pkinase       Protein kinase domain
    7.7e-26   90.9   0.0    1.1e-25   90.4   0.0    1.3  1  Pkinase_Tyr   Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  191.1   0.0   2.5e-60   2.2e-56       2     263 ..     289     557 ..     288     558 .. 0.88

  Alignments for each domain:
  == domain 1  score: 191.1 bits;  conditional E-value: 2.5e-60
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHS...CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS-- CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk...hpnivrlyevfeekdelylvleyveggeladllerkgsls 96 
                  ++ ++G+G++G+V  a++ + g++vAvK++ k+  k     + v++E++i+k l+   h+niv+++++ e++ e+++v+ey++gg l++   +  +++
  EFC36951.1 289 MVDDQIGKGTYGTVSLAMDLSLGRKVAVKRLCKKTVKLIGIeEYVQNEMEIMKLLRdnpHENIVQVLDIHESEAEYLFVMEYLSGGCLDNPFDEFEIIP 387
                 56789**************************9999888766699***********999***********************************9999** PP

                 HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGE.EEE.TTTE.EEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHH CS
     Pkinase  97 eeeakkiakqilegleylH.skgiiHrDlKpeNi.Lid.ekge.lKitDFGlakelesssk..ltsfvgtseYlAPEvlkeneyskkvDvWslGvilye 189
                 e++a+ ++ q++ ++++lH + +++HrD+ p+N  ++d ek + lK++DFGl+++ +  +k   t f+g s+Y  PE+l ++ y+++vDv++lGv+ly+
  EFC36951.1 388 ESQAQLYFCQLVDAVDHLHsKLKVLHRDIQPSNCcFLDtEK-KwLKLVDFGLSCQPTDFTKkeHTLFCGNSNYACPELLLKKAYGSEVDVYALGVLLYK 485
                 *******************5557**********73667444.36**********998877666999********************************* PP

                 HHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGG CS
     Pkinase 190 lltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpy 263
                 +l+g+ pf+g ++k     +  ++    ++ g +   + +  ++is+ +kdll+++l+++ +kR++++++++h++
  EFC36951.1 486 ILFGCFPFRGAQQKL---LMHFTVPLKDDVNGdDAMGSDDCGQNISKCCKDLLHNILEVNCEKRFSIQDIKNHQW 557
                 *********554444...222233334455555556677788999*****************************9 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.4   0.0   1.3e-29   1.1e-25       3     218 ..     290     505 ..     288     555 .. 0.78

  Alignments for each domain:
  == domain 1  score: 90.4 bits;  conditional E-value: 1.3e-29
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEE.STTSSHHH.HHHHHHHHHHHHTS...-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtl.keeateee.keelleeakimkkl...khpnivkllgvctkeepllivteyvkgGdLlkfLrkk 95 
                  +++++G+G++G+V  +       +   kVavK l k++ +    +e + +e++imk l    h+niv++l +  +e ++l+v+ey++gG+L++   + 
   EFC36951.1 290 VDDQIGKGTYGTVSLAMDL----SLGRKVAVKRLcKKTVKLIGiEEYVQNEMEIMKLLrdnPHENIVQVLDIHESEAEYLFVMEYLSGGCLDNPFDEF 383
                  5689**********99988....7899*****9955555555535556669999988764469********************************998 PP

                  CTTTSBHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGE.EE.EETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHH CS
  Pkinase_Tyr  96 ekekltlkdllsfalqvAkGmeyLesk.klvHrdlaarNv.Ll.senkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWs 190
                    e +  ++   +  q+ +++++L+sk k++Hrd+   N+ +l +e+k  k+ DfGL+ +  +d + ++++    + ++  pE l +k + s+ Dv++
   EFC36951.1 384 --EIIPESQAQLYFCQLVDAVDHLHSKlKVLHRDIQPSNCcFLdTEKKWLKLVDFGLSCQP-TDFTKKEHTLFCGNSNYACPELLLKKAYGSEVDVYA 478
                  ..8888888888999**********985799********8434246789*********998.4444455555567899******************** PP

                  HHHHHHHHHTTSSGTTTTSHHHHHHHHH CS
  Pkinase_Tyr 191 fGvllwEiftlgespypglkneevlekl 218
                   Gvll+ i+  g  p++g +++ ++++ 
   EFC36951.1 479 LGVLLYKILF-GCFPFRGAQQKLLMHFT 505
                  ********98.99999999888766543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       688  (0.0383736); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 3513.24
//
Query:       EFC36952.1  [L=200]
Description: hypothetical protein NAEGRDRAFT_75317 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.7e-12   45.0   0.0    2.4e-11   43.7   0.0    1.6  2  GST_C_3        Glutathione S-transferase, C-terminal domain
    1.6e-06   28.4   0.9    0.00019   21.7   0.1    2.4  2  GST_N          Glutathione S-transferase, N-terminal domain
    1.4e-05   25.2   0.0      3e-05   24.1   0.0    1.5  1  GST_C          Glutathione S-transferase, C-terminal domain
  ------ inclusion threshold ------
       0.15   12.5   0.0       0.27   11.8   0.0    1.3  1  CoA_binding_2  CoA binding domain


Domain annotation for each model (and alignments):
>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.2   5.3e+03      57      70 ..      57      70 ..      57      90 .. 0.64
   2 !   43.7   0.0   5.3e-15   2.4e-11       3      98 ..      98     197 ..      96     198 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.2
                HHHHHHHHHHHHHH CS
     GST_C_3 57 Dlalfqvldgleea 70
                D++++q l   +++
  EFC36952.1 57 DFHVYQTLAIARYL 70
                66666666655555 PP

  == domain 2  score: 43.7 bits;  conditional E-value: 5.3e-15
                 HHHHHHCCCC..SHCHHH.HHHHHHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHHTCCCC-HH.HHHHHHHHHTSHHHHHHHC CS
     GST_C_3   3 lhhpiaklly..dqkeea.ekkkefleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleeaealkkfpk.lkalyervearpkikaYle 97 
                 +  ++++++y  ++++e  e+ k+f+e +l+++++ ++++l   + gy++ + lT+ADl+l++++ +le+++++ +f + +++l++ + +++++k +le
  EFC36952.1  98 VLLEFFRVFYeiSNEKEReEELKKFKEGTLQRVFSGLNNLLNGTKCGYFIEGMLTWADLFLLEIVLNLESVGIDYSFANgIQRLKQILMENEQVKIHLE 196
                 5667899999874444446***********************88889************************7776775547788888899999998887 PP

                 T CS
     GST_C_3  98 s 98 
                 +
  EFC36952.1 197 T 197
                 6 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.1   4.3e-08   0.00019      27      76 .]      26      72 ..       6      72 .. 0.80
   2 !    5.1   0.1    0.0063        28      10      49 ..      84     123 ..      79     130 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 4.3e-08
                EEEEEEECSTTTCGGCHHHHHHCTT...S-SSEEEET.TEEEESHHHHHHHHHH CS
       GST_N 27 eyevvpldfeageekspellklnpl...gkvPaLedn.gkkltESraIleYiar 76
                ey+ + l+        + +++ +p+   g++P+L +  ++ + ++ aI++Y+a+
  EFC36952.1 26 EYQLTGLE-------GESWKNHKPFtryGQLPYLKVSdDFHVYQTLAIARYLAQ 72
                44444444.......267****************9988**************96 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0063
                 TSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHC CS
       GST_N  10 gsprahrirlllaakgveyevvpldfeageekspellkln 49 
                 + ++++ + + l +  +e+  v+++ ++ +e+++el+k +
  EFC36952.1  84 DAILTEEVVASLNEVLLEFFRVFYEISNEKEREEELKKFK 123
                 56677888888999999*********99999999999865 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0   6.8e-09     3e-05      11      75 ..     105     173 ..      95     188 .. 0.84

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 6.8e-09
                 HHHSTTH..HHHHHHHHHHHHHHHHHHHHHHHHHH..TSSSSSTTSSCHHHHHHHHHHHHHHHHTTTTT CS
       GST_C  11 lfyvkae..ekkeelvdealekvaevlsaleeelk..kqdylvGdkltlADialvpilnwlqrlglafg 75 
                 +fy  +   e++eel++ ++  + +v+s l++ l   k +y++   lt+AD+ l++i++ l+++g++ +
  EFC36952.1 105 VFYEISNekEREEELKKFKEGTLQRVFSGLNNLLNgtKCGYFIEGMLTWADLFLLEIVLNLESVGIDYS 173
                 4444444448999999999999************************************99999998765 PP

>> CoA_binding_2  CoA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0     6e-05      0.27      19      51 ..      66      97 ..      61     108 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 6e-05
                   HHHHHHHHT--EEEESSS-SEETTEES----T. CS
  CoA_binding_2 19 vlryllehglpvvpVnpkeeeilgekvyaslae 51
                   ++ryl ++g + +p n ++++il e+v+asl+e
     EFC36952.1 66 IARYLAQEG-NLYPLNERRDAILTEEVVASLNE 97
                   899******.********************984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1231.99
//
Query:       EFC36953.1  [L=531]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (531 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1446  (0.0806515); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.48
# Mc/sec: 3294.65
//
Query:       EFC36954.1  [L=790]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.1e-05   24.2   0.1    4.4e-05   23.2   0.1    1.5  1  Guanylate_cyc    Adenylate and Guanylate cyclase catalytic do
  ------ inclusion threshold ------
      0.011   15.5   0.2      0.011   15.5   0.2    1.7  2  dCache_1         Cache domain
        2.4    8.2   5.0       0.86    9.7   0.2    2.1  2  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.1   7.4e-09   4.4e-05       6     125 ..     560     676 ..     558     712 .. 0.76

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 7.4e-09
  Guanylate_cyc   6 ydevtilFadIvgftalssahspievvklLnelyarfdelldekk.vykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskegl 100
                    y++ +i++  I+g  +       +e+ +++  l++ + +++++ k   ++k   d +m+  +    + + a  +++++ +++++ e+++ + ++++
     EFC36954.1 560 YKDLCIVYVKIPGLDDRHYSN-YHELSHVVCRLISGVSSICKSMKaDLEIKSH-DEFMIKIDRF--SSSCADIALKISTALTSNNETFKRDGQPSI 651
                    667777777777776644433.5788888888888888888888855667764.8888888877..444444444555555667778888889*** PP

  Guanylate_cyc 101 kvrvGihtGpvvagviGakkprydv 125
                    kv +G+ +G +++g +G+k+ ry  
     EFC36954.1 652 KVHIGVASGNMLSGNVGNKTLRYSA 676
                    ***********************75 PP

>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.5   0.2   1.9e-06     0.011     100     180 ..     219     310 ..     104     376 .. 0.83
   2 ?   -3.2   0.1      0.97   5.8e+03      75      90 ..     484     498 ..     431     528 .. 0.53

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.9e-06
    dCache_1 100 g....tddpadrdwykealaggg....gkpvisdpyvdqtggkpvitiavpiyddsg......kfiGvlaadldldnlqdllsniklgetgyvfi 180
                      t+++a++dwy + ++  +    g   ++++y   + g + ++ ++p+yd+        + +G++ ++l+l  ++++l + kl +tg++ +
  EFC36954.1 219 IarniTYVVAKTDWYMASVEMLKtnpnGG--YGPVYKVLN-GGLAMYWSSPVYDRELlkanikQRVGIVKINLNLLKISQYLLSTKLLNTGFLVV 310
                 03344799*********999997554322..244554445.88**********954455556788****************999******99876 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.97
    dCache_1  75 sgvylvdadGqviass 90 
                 + + ++ +d++++a +
  EFC36954.1 484 NQFEYLKNDNNNLA-N 498
                 33333344444444.2 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.8      0.17     1e+03      42      60 ..      73      91 ..      56     103 .. 0.53
   2 ?    9.7   0.2   0.00014      0.86      18      57 ..     382     421 ..     381     431 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.17
  Phage_holin_3_6 42 aagvlallalllllvalal 60
                     + ++l++++l+ll+v+ ++
       EFC36954.1 73 LFLILVITGLILLTVFSIW 91
                     4444555555555554443 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00014
  Phage_holin_3_6  18 eleLakaElkeeakragsgagllgaagvlallalllllva 57 
                      ++ ++  E + +a+ ++s  ++lg+++++a+++++l +v 
       EFC36954.1 382 QITMFVEETEVKASAILSSYVILGVTLFFAIFGVVLSIVI 421
                      5789999***************************998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (790 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1035  (0.0577277); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.28s 00:00:01.03 Elapsed: 00:00:00.46
# Mc/sec: 5124.23
//
Query:       EFC36955.1  [L=141]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       430  (0.0239835); expected 358.6 (0.02)
Passed bias filter:                      266  (0.0148363); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 941.45
//
Query:       EFC36956.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-21   77.1   4.6    1.4e-19   70.4   1.0    2.1  2  CoaE        Dephospho-CoA kinase
  ------ inclusion threshold ------
      0.042   14.4   0.9       0.49   10.9   0.8    2.3  1  AAA_18      AAA domain
       0.21   11.2   1.0         12    5.6   0.0    2.7  3  STAR_dimer  Homodimerisation region of STAR domain protein


Domain annotation for each model (and alignments):
>> CoaE  Dephospho-CoA kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.1   0.1   0.00032       1.9       3      22 ..      11      29 ..       9      34 .. 0.86
   2 !   70.4   1.0   2.4e-23   1.4e-19      26     160 ..      51     202 ..      42     220 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00032
                EEEEESTTSSHHHHHHHHHH CS
        CoaE  3 vgltGgiasGKstvanlfad 22
                vgltG i sGKstv +++ +
  EFC36956.1 11 VGLTG-ICSGKSTVVSYLGE 29
                89996.*********99876 PP

  == domain 2  score: 70.4 bits;  conditional E-value: 2.4e-23
                 EEEEHHHHHHHTTCCTHHHHHHHHHHHG..........GGCB.TTSSE-HHHHHHHHHTSHHHHHHHHHHHHHHHHHHHHHHHHH--S......SEEEE CS
        CoaE  26 pivDaDlvArqvvepgsealkkiveeFg..........eeildedGeLdReaLrkkvFadpeekkaLnallhPlirreikkelakles......kyvll 108
                 +++ +D +  ++   g+e +k++ve F           +++lde+ +++R++L++ vF + e  k+L  ++ P ++r i+ e++k+e+       ++l+
  EFC36956.1  51 HVIPTDELGWKAYSVGTECYKQVVEVFTplvkqivgeeASLLDEQQQINRRMLGRVVFGNSELMKKLTDIVWPEVKRLINVEISKAEQeainekVVCLI 149
                 677777788888888888888888888777777777668899*************************************9999998877777777899* PP

                 E-TTTTTTTGGGGSSEEEEEE--.HHHHHHHHHHCCTSTHHHHHHHHHHS--H CS
        CoaE 109 dvPLLvEkqlekliervlvvdve.lelqveRlvardgvseeevkaiiaaQlse 160
                 +   Lv++++++ i++v+v+dv+ +e++++Rl +r++++ ee+k++i++Q+  
  EFC36956.1 150 ESAVLVDAEWQQGIDKVWVIDVSnTEERIQRLCSRNQLTIEEAKQRINSQAIA 202
                 *********************973689***********************865 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.8   8.3e-05      0.49       4     119 ..      14     190 ..      11     202 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8.3e-05
      AAA_18   4 tGtpGvGKttlakeLskrl.gf.................gvnlrdvakenglllevdpe.aldeskrldedkldklldaleenss.............. 69 
                 tG +++GK+t+  +L ++  ++                 ++   ++ ++ +++ ++  +  ++ +  l+++ + +  ++l+e+ +              
  EFC36956.1  14 TG-ICSGKSTVVSYLGELIkEYeqlhsqspsehhkiffhVIPTDELGWKAYSVGTECYKqVVEVFTPLVKQIVGEEASLLDEQQQinrrmlgrvvfgns 111
                 55.479*********988777788888888888666776444444444444444444445444444444444444444444444444466666666666 PP

      AAA_18  70 ............................aleegknlvidghlaeleseaakdikkvvLtasp.eelleRlekRgyeeak 119
                                             a  e  +++i++ +    ++++ + k  v+++s+ ee+++Rl  R++ + +
  EFC36956.1 112 elmkkltdivwpevkrlinveiskaeqeAINEKVVCLIESAVLVDAEWQQGIDKVWVIDVSNtEERIQRLCSRNQLTIE 190
                 6666888888888888888888888876666666668887666555555555554888888889999999988876655 PP

>> STAR_dimer  Homodimerisation region of STAR domain protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0    0.0094        56       6      28 ..      24      51 ..      20      52 .. 0.71
   2 ?   -2.8   0.0      0.81   4.9e+03      11      20 ..      90      99 ..      89     100 .. 0.79
   3 ?    5.6   0.0     0.002        12      19      39 ..     114     135 ..     111     144 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.0094
  STAR_dimer  6 pdYLaqLLkdKKqlaafpn.....vftH 28
                + YL +L+k+  ql + +      +f H
  EFC36956.1 24 VSYLGELIKEYEQLHSQSPsehhkIFFH 51
                67********999876544355555555 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.81
  STAR_dimer 11 qLLkdKKqla 20
                 LL +++q++
  EFC36956.1 90 SLLDEQQQIN 99
                6999999986 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.002
  STAR_dimer  19 laafpn.vftHlerLLdeEIsR 39 
                 ++++++ v + ++rL++ EIs+
  EFC36956.1 114 MKKLTDiVWPEVKRLINVEISK 135
                 67778878999**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       982  (0.0547716); expected 358.6 (0.02)
Passed bias filter:                      555  (0.0309554); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 1749.03
//
Query:       EFC36957.1  [L=809]
Description: RGS domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-19   68.2  21.9    2.5e-11   43.9   4.4    4.2  5  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.025   14.6   0.2       0.13   12.3   0.1    2.3  2  DEP       Domain found in Dishevelled, Egl-10, and Pleckstrin
      0.054   13.6   2.2       0.12   12.4   0.9    2.3  2  ORF6C     ORF6C domain
      0.056   13.5   0.2        1.7    8.7   0.0    2.6  2  DUF3921   Protein of unknown function (DUF3921)


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       1.8   7.9e+03      12      58 ..     160     205 ..     150     218 .. 0.67
   2 ?   -3.5   0.0       2.7   1.2e+04      72      99 ..     335     360 ..     306     362 .. 0.60
   3 !   43.9   4.4   5.7e-15   2.5e-11       2      91 ..     482     573 ..     481     601 .. 0.81
   4 ?    1.0   0.7      0.11   4.8e+02      22      97 ..     563     636 ..     556     639 .. 0.72
   5 !   35.1   1.3     3e-12   1.3e-08       2     109 ..     682     795 ..     681     800 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.8
                 HHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHT CS
         RGS  12 rslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneyl 58 
                 ++ F + l s+ +++++ ++  ++     k++ ++++k++++y+ + 
  EFC36957.1 160 CKTFISLLTSQLHKQQMLYFPSINYAGI-KSHMDIVEKINSLYKIFN 205
                 5666666666666666666666654443.488888888888888775 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.7
                 HHHHHHHHHCSS......STTTTTTHHHHHHHHH CS
         RGS  72 lreelekrleke......qpsrklfeeaqeevfe 99 
                 l +        +        +++ fe++q ++ +
  EFC36957.1 335 LQK--------SsllnliVSQEREFEMIQGHIKK 360
                 333........23333334677788888888875 PP

  == domain 3  score: 43.9 bits;  conditional E-value: 5.7e-15
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSS..TS-HHHHHHHHHHHCSSSTTTTTTH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkel..nidkklreelekrlekeqpsrklfe 91 
                 +++ l++++  + F++++ + +seen+ Fw++++ +k+ ++ +e+k k+ke+++++++++sp++   n+++k++++  +  e+++++ + f 
  EFC36957.1 482 VQQALNNPTINEEFTQYCTKDHSEENILFWKEIQSYKRIQSPSERKLKFKELVSQFVSSNSPHSTpvNLESKIVTSFLTLAEENEENISFFS 573
                 678899********************************************************66545*******999988888755554443 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.11
                 TTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSS..TS-HHHHHHHHHHHCSSSTTTTTTHHHHHHH CS
         RGS  22 efseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkel..nidkklreelekrlekeqpsrklfeeaqeev 97 
                 e++een+sF+  +e f++   +  +++  k+ + ++  ++ +ke+  +id+   +   + ++keq s++ + ++ +++
  EFC36957.1 563 EENEENISFF-STEVFNEL--EWLVVNNLKDTFTRFN-DERNKEIdsQIDELQQNLRLEAIKKEQHSKSFLSQVASAI 636
                 5667999997.46788877..7788888899999988.5666666567887777777788888888888887777766 PP

  == domain 5  score: 35.1 bits;  conditional E-value: 3e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTS.........TTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneyla.........psspkelnidkklreelekrlekeqpsrklfe 91 
                 le +l ++  r+ Fr F+++e++ee++ F++ v+e+k+ + + ++ kka+eI+n +++         ++  + l+  k+ re+++k+l       ++f+
  EFC36957.1 682 LEAVLCSPNARKQFRIFCKKEHAEEYILFLDSVDEYKTFTGKLDRCKKAHEIFNIFIElptsgsflhEEDVRTLDCTKDERETIRKKLDS--GELEMFD 778
                 7889999***********************************************998521111111022333334444444444444444..7888888 PP

                 HHHHHHHHHHHHHHHHHH CS
         RGS  92 eaqeevfellekdsypkF 109
                 ++  ++++ +  d y++F
  EFC36957.1 779 AVVISIQNQML-DVYNRF 795
                 88888888884.566666 PP

>> DEP  Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.71   3.2e+03       9      31 ..     147     171 ..     139     175 .. 0.76
   2 ?   12.3   0.1   2.9e-05      0.13      37      72 .]     232     267 ..     224     267 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.71
                 CT..TEEESSE-HHHHHHHHHHHHT CS
         DEP   9 kh..lktypncftGseavdWLldnl 31 
                  +  +k + ++ft +  ++ L ++l
  EFC36957.1 147 SKslKKNFDKVFTCKTFISLLTSQL 171
                 444589999********99998876 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.9e-05
                 HHHHHHHHHHHHCTSCECSSSSHCC.--SSSSS-EEE CS
         DEP  37 eeAvalgqlLldqgliehvedkhqe.FrdskqafYqf 72 
                  +A+++gq Ll+ g+i++++++++  F +  +++Y+f
  EFC36957.1 232 VQAETFGQFLLEIGIIQNIKPEKKRkFAER-SHYYMF 267
                 68*****************8888777****.699987 PP

>> ORF6C  ORF6C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       1.6   7.4e+03      71      95 ..      37      61 ..      24      64 .. 0.76
   2 ?   12.4   0.9   2.7e-05      0.12      13      64 ..     597     648 ..     588     653 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.6
       ORF6C 71 sdiyrdlkrefgVasYkdikkkdfd 95
                 d++++lk++   a Y++i +++++
  EFC36957.1 37 VDLKHSLKDLSSFALYERIEQQHLK 61
                5788899999999999999888765 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 2.7e-05
       ORF6C  13 dekieeidervkkLeenmpldesekeeiqkkvkkkvvellggkkspaykdks 64 
                 de+ +eid+++++L++n++l++ +ke+ +k   ++v++++g kk+++ + ++
  EFC36957.1 597 DERNKEIDSQIDELQQNLRLEAIKKEQHSKSFLSQVASAIGRKKTNSTSTNN 648
                 78899*****************************************998877 PP

>> DUF3921  Protein of unknown function (DUF3921)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0   0.00038       1.7       7      32 ..     352     377 ..     349     395 .. 0.83
   2 ?    1.7   0.1      0.06   2.7e+02      14      36 ..     593     612 ..     586     623 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00038
     DUF3921   7 smiqkaihrtydelGkeldlqGvvvd 32 
                  miq  i +t++e+ +e ++ G   d
  EFC36957.1 352 EMIQGHIKKTHEEIAQESNSSGSSLD 377
                 6********************98777 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.06
     DUF3921  14 hrtydelGkeldlqGvvvdeiqk 36 
                  r  de  ke+d+q   +de+q+
  EFC36957.1 593 TRFNDERNKEIDSQ---IDELQQ 612
                 57789********9...688775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (809 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1379  (0.0769145); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.79u 0.33s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 4553.68
//
Query:       EFC36958.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.6e-21   75.5   0.0    5.4e-21   74.5   0.0    1.5  1  ADH_N_2       N-terminal domain of oxidoreductase
    7.3e-18   64.8   0.0    1.2e-17   64.1   0.0    1.4  1  ADH_zinc_N    Zinc-binding dehydrogenase
    5.4e-10   40.4   0.0    1.7e-09   38.8   0.0    1.8  2  ADH_zinc_N_2  Zinc-binding dehydrogenase
  ------ inclusion threshold ------
      0.032   13.3   0.0      0.049   12.6   0.0    1.2  1  Gly_kinase    Glycerate kinase family
       0.14   12.2   0.0       0.35   10.9   0.0    1.6  1  Terminase_6C  Terminase RNaseH-like domain
       0.17   11.2   0.0       0.26   10.6   0.0    1.2  1  PALP          Pyridoxal-phosphate dependent enzyme


Domain annotation for each model (and alignments):
>> ADH_N_2  N-terminal domain of oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.5   0.0   1.8e-24   5.4e-21       3     101 ..       8     113 ..       6     121 .. 0.87

  Alignments for each domain:
  == domain 1  score: 74.5 bits;  conditional E-value: 1.8e-24
     ADH_N_2   3 wvlkkrpegaptesdfeleeeelp....elkdGevlvralylSvDPymRgrmnd...aksyvepvelgdvmrggavgeVveSknpdfkvGdlVvgllgw 94 
                 +++++ peg+++e dfe++++       +l++++++v+ l++SvDPy Rgrm++   ak+y++ ++ g+++ +g+v++V++S+++ fk+Gd+ vg+ +w
  EFC36958.1   8 LIFTNYPEGMIKETDFEYTDQVPFnfdqSLDQDQIMVQLLHISVDPYLRGRMRKnamAKHYAATFQTGKPISSGCVAKVLKSNHSVFKEGDVLVGHFEW 106
                 577899***********9876432233479999*******************97444699999************************************ PP

     ADH_N_2  95 qdyavsd 101
                 q + +++
  EFC36958.1 107 QLHQIVK 113
                 **99985 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.1   0.0     4e-21   1.2e-17       1     120 [.     172     310 ..     172     320 .. 0.82

  Alignments for each domain:
  == domain 1  score: 64.1 bits;  conditional E-value: 4e-21
                 HHHHHHHHHHHHTT-EEEEEESSHH.HHHHHHHTTESEEEETTTC.H....HHHHHHHHTT.TSSEEEEEESSCSHHHHHHHHHCEEEEEEEEECSC.. CS
  ADH_zinc_N   1 gvGlaavqlAkalGaeviavdssee.klelakklGadevinykea.d....lverikeltg.gegvdvvfecvGsgatleaalkllkpgGrlvvvGg.. 90 
                 +vG+++ q+Ak+ G++vi++ +++  + + +k+lG d+++nyk+  +    l+++i+++ + + g+d +f+ vG g +l+aa+ ++++ Gr+ ++G   
  EFC36958.1 172 AVGSLVGQIAKIHGCKVIGITGQPAeNQQELKDLGFDVILNYKDYnNdpiaLKDAIEKAAEpKTGIDCYFDNVG-GFVLDAATLAMNRYGRISCCGSis 269
                 69*****************88877538899************5554467779999999999999**********.**********************86 PP

                 TSSEEE......EEHHHHH.HTT-EEEEE-SSC....HHHH CS
  ADH_zinc_N  91 gkgeee......fdlrnll.lkeksilGsllgs....lree 120
                  ++ e+       +l++l   +e+s++G++++s    l e 
  EFC36958.1 270 DYNIEDrmsnlgPRLNYLYiTRELSVKGFIVSSfynrLDEG 310
                 66666698776655555555**********99944444444 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0         2   5.8e+03      39      55 ..     152     169 ..     117     204 .. 0.66
   2 !   38.8   0.0   5.8e-13   1.7e-09       1     133 []     205     354 ..     205     354 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2
                   HHHHE.EEEEEEEE---- CS
  ADH_zinc_N_2  39 slkvl.pggGrlvsiggp 55 
                    l+++ p++G++v++++ 
    EFC36958.1 152 FLDICqPKEGDVVVVSAA 169
                   456666777887777643 PP

  == domain 2  score: 38.8 bits;  conditional E-value: 5.8e-13
                   TT-SEEE...ETTSTTHH.......HHH-TT-EEEEEES-HHHHH.HHHHHHEEEEEEEEE----.S-EEE-CHHHCTTT-EEEE--GGG...-... CS
  ADH_zinc_N_2   1 lGAdevi...dyrtedfe.......aatggegvDvvldtvggealleaslkvlpggGrlvsiggpplsaallkpakkrkgrsvkyeflfsmkas... 84 
                   lG+d ++   dy ++ ++       aa  + g+D  +d+vgg  l +a+  +++ +Gr+ + g+  +s+   + +  + g++++y  ++ ++ s   
    EFC36958.1 205 LGFDVILnykDYNNDPIAlkdaiekAAEPKTGIDCYFDNVGGFVL-DAATLAMNRYGRISCCGS--ISDYNIEDRMSNLGPRLNYLYIT-RELSvkg 297
                   68888884444444444488888753333489***********99.8887788999***88775..33333333332333444443333.4444556 PP

                   .........-HHHHHHHHHHHHHHH----EEEEEEGGGHHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  85 ........aqadileelaalieeGklrpvvdrvfpleeaaeAhrylesgrarGKiVl 133
                           +  +  +++++++ eGkl++  ++v +le++++A+ +l +g  +GK+++
    EFC36958.1 298 fivssfynRLDEGVKKMTQWVNEGKLKVLESKVQGLENVPKALIKLFTGDKFGKMII 354
                   66666698666669*****************************************97 PP

>> Gly_kinase  Glycerate kinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.6e-05     0.049     291     352 ..     168     232 ..     160     235 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.6e-05
  Gly_kinase 291 tlsGKvpvgvaklakkagvpvialaGsveedaeeleeagidavf...sildgpesleealeeaae 352
                  +sG v + v ++ak +g++vi ++G+ +e+++el++ g+d ++      + p  l++a+e+aae
  EFC36958.1 168 AASGAVGSLVGQIAKIHGCKVIGITGQPAENQQELKDLGFDVILnykDYNNDPIALKDAIEKAAE 232
                 578999999******************************99998222455677889999988875 PP

>> Terminase_6C  Terminase RNaseH-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00012      0.35      22     116 ..     203     332 ..     185     348 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00012
                   TTTCEEEEEEEEESSS-CCCHHHHHHHHHHCTTCEEEEECCSCHHHHHHHHHHCCT--S-......................SCEESSH........ CS
  Terminase_6C  22 kddkfellavlherglspalqaaaikklaerynviyvyieitsaGesvaellkrdlesea......................lavkpepas...... 90 
                   kd +f ++  +++ +++p  +++ai+k+ae ++ i +y +  ++    a++l+++  + +                      l+++++ ++      
    EFC36958.1 203 KDLGFDVILNYKDYNNDPIALKDAIEKAAEPKTGIDCYFDNVGGFVLDAATLAMNR-YGRisccgsisdyniedrmsnlgprLNYLYITRElsvkgf 298
                   6678999999******************************************9998.5556888888888888888888888777777666777777 PP

                   ......HHHHHHHHHHHHHHHTTSEEEETHH..C CS
  Terminase_6C  91 ......kdkatrvskvkdliesgrlkvdkga..e 116
                         +    +v+k+ + + +g+lkv++++   
    EFC36958.1 299 ivssfyNRLDEGVKKMTQWVNEGKLKVLESKvqG 332
                   7777778888888888888888888888875554 PP

>> PALP  Pyridoxal-phosphate dependent enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   8.8e-05      0.26      52     124 ..     159     229 ..     142     261 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 8.8e-05
                 TTTTSEEEEEBSSHHHHHHHHHHHHHT-EEEEEEETTS-HHHHHHHHHTT-EEEEECCHHHHHHHHHHHHHHH CS
        PALP  52 gtgaktvveassGNhgralAaaaallGlkvtivvpadaspekvallrllGaevvevggdydeavaaaaelaae 124
                 ++g  +vv a sG  g  +  +a+  G+kv+    +  ++e+++ l+ lG +v++  +dy++   a ++++++
  EFC36958.1 159 KEGDVVVVSAASGAVGSLVGQIAKIHGCKVIGITGQ--PAENQQELKDLGFDVILNYKDYNNDPIALKDAIEK 229
                 457889999999***************777777655..557***************99988877765544433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       503  (0.0280551); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 2364.75
//
Query:       EFC36959.1  [L=391]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       827  (0.0461264); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.26s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2512.03
//
Query:       EFC36960.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-37  125.3  18.4    5.1e-09   36.6   0.2    7.3  7  WD40         WD domain, G-beta repeat
    7.4e-14   51.8   0.1      0.017   15.4   0.0    6.4  7  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    1.2e-05   25.3   0.0     0.0089   15.9   0.0    2.5  3  eIF2A        Eukaryotic translation initiation factor eIF2A
    0.00011   21.3   1.3        1.7    7.5   0.0    3.6  3  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
  ------ inclusion threshold ------
       0.13   11.4   0.0        0.2   10.8   0.0    1.2  1  CshA_NR2     Surface adhesin CshA non-repetitive domain 2


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.1   4.4e-08   0.00016       5      38 .]      51      87 ..      47      87 .. 0.86
   2 !   14.6   0.1   1.3e-05     0.046       6      38 .]      91     129 ..      88     129 .. 0.76
   3 !   13.1   0.3   3.9e-05      0.14       5      38 .]     147     181 ..     143     181 .. 0.76
   4 !   18.7   0.1   6.4e-07    0.0023       1      38 []     185     223 ..     185     223 .. 0.94
   5 !   36.6   0.2   1.4e-12   5.1e-09       1      38 []     227     265 ..     227     265 .. 0.97
   6 !   10.6   0.1   0.00023      0.84      14      38 .]     285     309 ..     277     309 .. 0.94
   7 !   17.4   0.0   1.7e-06    0.0061      12      37 ..     325     354 ..     313     354 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 4.4e-08
                EEEESS.SSEEEEE..EETTSSEEEEEETTSEEEEEE CS
        WD40  5 rtltGH.ssvtsla..fspdgawlasGsdDgtvriWd 38
                 tl+GH + v+s+a    pd+++l+s+s Dg++ iW+
  EFC36960.1 51 NTLRGHlGKVYSCAwsPVPDSKLLVSASQDGKLIIWN 87
                689***999****966777777799***********8 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1.3e-05
                 EEESS......SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   6 tltGH......ssvtslafspdgawlasGsdDgtvriWd 38 
                 t++ H      ++v  +++s +g+++asG+ D+ v i++
  EFC36960.1  91 TFKQHaitlrtNWVMTCSYSNSGQYVASGGLDNIVSIFN 129
                 666663322223588999******************987 PP

  == domain 3  score: 13.1 bits;  conditional E-value: 3.9e-05
                 EEEESS.SSEEEEE.EETTSSEEEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtsla.fspdgawlasGsdDgtvriWd 38 
                 r+l+ H + +++++  s d++ l+s++ D t+  Wd
  EFC36960.1 147 RELSQHtGYISACKfISNDKQILSSSG-DMTCICWD 181
                 78999*666****95666666665556.*******9 PP

  == domain 4  score: 18.7 bits;  conditional E-value: 6.4e-07
                 TEEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   1 gqclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 g++++t+  H ++  s+++spd + ++sG+ D   ++Wd
  EFC36960.1 185 GRPIKTFQSHtGDCMSVSVSPDESQFVSGGCDAYAKLWD 223
                 6799******88899**************88*******9 PP

  == domain 5  score: 36.6 bits;  conditional E-value: 1.4e-12
                 TEEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   1 gqclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 g+c+ t+ GH s+v++++f p+g  +a++sdD+t+r++d
  EFC36960.1 227 GKCVATFGGHdSDVNCVQFFPNGLSFATASDDNTCRLFD 265
                 79********999************************98 PP

  == domain 6  score: 10.6 bits;  conditional E-value: 0.00023
                 EEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  14 tslafspdgawlasGsdDgtvriWd 38 
                 ts++fs++g+++ ++ d ++v +Wd
  EFC36960.1 285 TSISFSKSGRLMYAAYDEKSVVVWD 309
                 89**********************9 PP

  == domain 7  score: 17.4 bits;  conditional E-value: 1.7e-06
                 S....EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  12 s....vtslafspdgawlasGsdDgtvriW 37 
                 +    v +la+spdg+ la++s+D ++ +W
  EFC36960.1 325 GpegrVACLAVSPDGNALATASWDFNLQVW 354
                 2344599*********************** PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0    0.0013       4.8      39      81 ..      58     102 ..      47     111 .. 0.80
   2 ?    2.5   0.0     0.051   1.8e+02      41      69 ..     104     132 ..     100     144 .. 0.86
   3 ?    3.5   0.0     0.025        89      37      83 ..     152     198 ..     144     204 .. 0.86
   4 !    8.1   0.0   0.00089       3.2      42      89 ..     199     245 ..     192     248 .. 0.87
   5 !   12.9   0.0   2.9e-05       0.1      28      74 ..     229     273 ..     219     281 .. 0.82
   6 !   15.4   0.0   4.8e-06     0.017      38      87 ..     281     333 ..     270     337 .. 0.85
   7 ?    3.7   0.0     0.022        78      35      59 ..     324     348 ..     321     354 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0013
  ANAPC4_WD40  39 sevrsLaWk..pdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                  ++v s aW+  pd klL+ a +dg++ + +a ++   h+++  ++
   EFC36960.1  58 GKVYSCAWSpvPDSKLLVSASQDGKLIIWNALTTFKQHAITLRTN 102
                  6889999984459****************9998888777776665 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.051
  ANAPC4_WD40  41 vrsLaWkpdgklLavaysdgevrlldaes 69 
                  v   +++++g+  a +  d+ v+++++++
   EFC36960.1 104 VMTCSYSNSGQYVASGGLDNIVSIFNINQ 132
                  5667899******************9876 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.025
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvkseka 83 
                  + + +++ ++  ++k +  +  d ++   d+e g+ +++++ ++ ++
   EFC36960.1 152 HTGYISACKFISNDKQILSSSGDMTCICWDIEMGRPIKTFQSHTGDC 198
                  56678888999999***************************998863 PP

  == domain 4  score: 8.1 bits;  conditional E-value: 0.00089
  ANAPC4_WD40  42 rsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                   s++ +pd++ ++ +  d   +l d+ sgk+v ++  ++++ v+c+++
   EFC36960.1 199 MSVSVSPDESQFVSGGCDAYAKLWDIRSGKCVATFGGHDSD-VNCVQF 245
                  56778999***************************999885.***987 PP

  == domain 5  score: 12.9 bits;  conditional E-value: 2.9e-05
  ANAPC4_WD40  28 rvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvh 74 
                   v t+   ++ds v+++++ p+g  +a a +d+++rl+d+   + + 
   EFC36960.1 229 CVATF--GGHDSDVNCVQFFPNGLSFATASDDNTCRLFDIRASRELM 273
                  44455..789*****************************98776665 PP

  == domain 6  score: 15.4 bits;  conditional E-value: 4.8e-06
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksek...avtcl 87 
                   +  +s++++++g+l+  ay++ +v + d  +gk+v++l+ +++    +v+cl
   EFC36960.1 281 REGATSISFSKSGRLMYAAYDEKSVVVWDTLKGKIVQNLTSEQNGpegRVACL 333
                  566789*********************************99987666677776 PP

  == domain 7  score: 3.7 bits;  conditional E-value: 0.022
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysd 59 
                  ++++++v +La +pdg+ La a  d
   EFC36960.1 324 NGPEGRVACLAVSPDGNALATASWD 348
                  567899**************99766 PP

>> eIF2A  Eukaryotic translation initiation factor eIF2A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   2.5e-06    0.0089      60     159 ..      58     157 ..      46     176 .. 0.86
   2 !    7.2   0.0    0.0011       4.1      51     160 ..     188     298 ..     151     322 .. 0.69
   3 ?   -0.4   0.0      0.25   8.9e+02     104     163 ..     285     347 ..     255     353 .. 0.55

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 2.5e-06
                 S.EEEEEE-TTSS-EEEEESSSSCEEEEEECS...CEEEEEEEEES--EEEE-TTSSEEEEE-TTSSS-EEEEEETTTTEEEEEEE-TT--EEEE-TTS CS
       eIF2A  60 gpihdvaWspkskefaviyGkmpakvslfdlk...vkviskleeqkrNtiffspkgklvllaGfgnlaGeleiwdvkkkkkiakaeaanatlvewspdg 155
                 g+++  aWsp  +  +++   ++ k  +++      +   +l+++   t  +s++g++v+ +G+ n+   ++i++ ++++  +   ++++ + e s++ 
  EFC36960.1  58 GKVYSCAWSPVPDSKLLVSASQDGKLIIWNALttfKQHAITLRTNWVMTCSYSNSGQYVASGGLDNI---VSIFNINQLTDASDSTQPTTPHRELSQHT 153
                 7899**************************953445566677888888999****************...*********99999999999999988888 PP

                 SEEE CS
       eIF2A 156 ryvl 159
                  y+ 
  EFC36960.1 154 GYIS 157
                 7775 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0011
                 EEECCEESSS.EEEEEE-TTSS-EEEEESSSSCEEEEEECS.CEEEEEEE..EES--EEEE-TTSSEEEEE-TTSSS-EEEEEETTTTEEEEEEE.... CS
       eIF2A  51 sevvelkkegpihdvaWspkskefaviyGkmpakvslfdlk.vkviskle..eqkrNtiffspkgklvllaGfgnlaGeleiwdvkkkkkiakae.... 142
                 +++++ +++g+   v+ sp++++f  + G  +a ++l+d + +k +++++   +  N++ f p+g  +++a   n+     ++d    +++  ++    
  EFC36960.1 188 IKTFQ-SHTGDCMSVSVSPDESQF--VSGGCDAYAKLWDIRsGKCVATFGghDSDVNCVQFFPNGLSFATASDDNT---CRLFDIRASRELMDYKddsi 280
                 44444.467788888888888888..79************7777777776215678*********99999998888...44555553333333321111 PP

                 -TT--EEEE-TTSSEEEE CS
       eIF2A 143 aanatlvewspdgryvlT 160
                  + at++ +s +gr++  
  EFC36960.1 281 REGATSISFSKSGRLMYA 298
                 456788888888887765 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.25
                 -EEEE-TTSSEEEEE-TTSSS-EEEEEETTTTEEEEEEE-TT-......-EEEE-TTSSEEEEEE- CS
       eIF2A 104 NtiffspkgklvllaGfgnlaGeleiwdvkkkkkiakaeaana......tlvewspdgryvlTatt 163
                  +i fs++g+l+  a + +   ++ +wd+ k k ++++ +++         +  spdg+ ++Ta+ 
  EFC36960.1 285 TSISFSKSGRLMY-AAYDEK--SVVVWDTLKGKIVQNLTSEQNgpegrvACLAVSPDGNALATASW 347
                 5566666666654.334444..56667777666666655544211111134566777777777765 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.2    0.0021       7.5     187     249 ..     101     167 ..      84     212 .. 0.71
   2 !    5.0   0.0    0.0027       9.7     186     218 ..     236     268 ..     223     276 .. 0.87
   3 !    7.5   0.0   0.00049       1.7     189     214 ..     329     354 ..     294     355 .] 0.71

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0021
    Ge1_WD40 187 hsliveaafspdGtalatasedGevkffqvylede....eeprCLh.eWkPhdGkslssllfldnhke 249
                 +  +++ ++s  G  +a    d +v  f +++  +    ++p   h e   h G  +s+  f+ n k+
  EFC36960.1 101 TNWVMTCSYSNSGQYVASGGLDNIVSIFNINQLTDasdsTQPTTPHrELSQHTG-YISACKFISNDKQ 167
                 2349999***********************986443444667666624555666.4666666666554 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0027
    Ge1_WD40 186 ehsliveaafspdGtalatasedGevkffqvyl 218
                 ++s + +  f p+G + atas d + ++f +  
  EFC36960.1 236 HDSDVNCVQFFPNGLSFATASDDNTCRLFDIRA 268
                 45789999*********************9965 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.00049
    Ge1_WD40 189 liveaafspdGtalatasedGevkff 214
                  + + a+spdG alatas d  ++ +
  EFC36960.1 329 RVACLAVSPDGNALATASWDFNLQVW 354
                 488999************99777655 PP

>> CshA_NR2  Surface adhesin CshA non-repetitive domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   5.5e-05       0.2     249     290 ..     101     142 ..      76     163 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 5.5e-05
                 EEEEEECSXSEEEEEEEESSXXEEEEEEEXXXXXXXXXXXXX CS
    CshA_NR2 249 vpivltrgasevGlyiassGqqaamigflkvdegdapesygk 290
                 ++ v+t ++s+ G y+as+G ++++  f     +da +s  +
  EFC36960.1 101 TNWVMTCSYSNSGQYVASGGLDNIVSIFNINQLTDASDSTQP 142
                 578******************999988887788999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       703  (0.0392102); expected 358.6 (0.02)
Passed bias filter:                      647  (0.0360868); expected 358.6 (0.02)
Passed Vit filter:                        90  (0.0050198); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.47
# Mc/sec: 2259.68
//
Query:       EFC36961.1  [L=220]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   15.6   0.1      0.022   14.9   0.1    1.3  1  DUF305    Domain of unknown function (DUF305)
       0.09   12.9   2.3          2    8.5   0.1    2.7  2  Vps51     Vps51/Vps67


Domain annotation for each model (and alignments):
>> DUF305  Domain of unknown function (DUF305)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   0.1   2.5e-06     0.022      94     151 ..      66     124 ..      58     125 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.5e-06
                 S-HHHHHHHHHHHHHHHHHHHHHHHGGGG-.----HHHHHHHHHHHHHHHHHHHHHHHH CS
      DUF305  94 asgadfdrlFlelMirhHqgavemaeaale.kgedpevrelaeaiieaQqaEieqmqel 151
                  s  +f  l+++ Mi+  + ++e+ae  l+ + +++e  +l++++ ++ ++  ++++el
  EFC36961.1  66 HSNSNFTSLWINFMIASKREGIELAEFGLNsQNSNQEFLSLMQEMKNNATETKTKLEEL 124
                 567899********************98875788999********99988877777776 PP

>> Vps51  Vps51/Vps67
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.3     0.011        95      17      49 ..     111     143 ..      96     144 .. 0.67
   2 ?    8.5   0.1   0.00023         2      42      70 ..     186     214 ..     171     216 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.011
       Vps51  17 akstlkellkveasllseiraldselkalVydn 49 
                 +++  ++  k+e+ l   +  + +e++alVy n
  EFC36961.1 111 KNNATETKTKLEELLFTLNLPTMNEMQALVYGN 143
                 444445555666666666777778899999887 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00023
       Vps51  42 lkalVydnYskLisasdtIrkmksemdkl 70 
                  +++V   Y++Li+ s+tI k+ +  ++l
  EFC36961.1 186 DQRVVSIAYNELITSSKTIGKLLQLSKSL 214
                 57888889************997766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       813  (0.0453455); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.26s 00:00:00.66 Elapsed: 00:00:00.43
# Mc/sec: 1531.08
//
Query:       EFC36962.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1296  (0.0722851); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.52
# Mc/sec: 1286.83
//
Query:       EFC36963.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-50  170.4   1.3    6.2e-50  169.5   1.3    1.5  1  Pro_CA    Carbonic anhydrase


Domain annotation for each model (and alignments):
>> Pro_CA  Carbonic anhydrase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.5   1.3   3.5e-54   6.2e-50       1     155 [.     174     325 ..     174     326 .. 0.96

  Alignments for each domain:
  == domain 1  score: 169.5 bits;  conditional E-value: 3.5e-54
                 EEEEEETTTTS-HHHHTTS-TTSEEEEEETTG---TT-HHHHHHHHHHHHTS--SEEEEEEETT-HHHHHHHSHHCCSTTSSHHHHHHHHHHHHHHHCH CS
      Pro_CA   1 alvigCsDSRvppelitdagpGdlFvvrnvgnlvppadssvlaaleyAvevlkvkhivVlGHskCGavkaalkaekseeeagaidkwlekirealekve 99 
                 +++igCsDSRvpp+++t+++pG++F++rnv+nlv+++d + +++l+yAvevl+vkh++V+GH++CG+v aal++    ++ g id+wl++i+++++ ++
  EFC36963.1 174 YMLIGCSDSRVPPDQLTKTQPGQIFIHRNVANLVVNTDVNAMSVLQYAVEVLQVKHVIVMGHTRCGGVMAALTN----KHLGLIDHWLRNIKDVYRLHK 268
                 589******************************************************************99985....2379***************** PP

                 HHHHTTSSHHHHHHHHHHHHHHHHHHHHHCSHHHHHHHHTTS.-EEEEEEEETTTTE CS
      Pro_CA 100 eelesekekearerlleeenVaeqlenLlekpvvreavekgk.lkvhGlvydletGe 155
                 +e +++++k+++ +++ e+n+ eq  nL++++vv++a++kg+ l+vhG++ d+etG 
  EFC36963.1 269 AEVDAIEDKDKKIHRMIELNIIEQTLNLCKTSVVQNAWAKGRtLHVHGWLCDIETGL 325
                 **9**99999888888*************************99************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       690  (0.0384851); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 2050.35
//
Query:       EFC36964.1  [L=307]
Description: spoU protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.6e-28   98.5   0.0    3.4e-26   92.1   0.0    2.2  1  SpoU_methylase  SpoU rRNA Methylase family


Domain annotation for each model (and alignments):
>> SpoU_methylase  SpoU rRNA Methylase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.1   0.0   1.9e-30   3.4e-26       5     142 .]      51     238 ..      48     238 .. 0.78

  Alignments for each domain:
  == domain 1  score: 92.1 bits;  conditional E-value: 1.9e-30
                     EEES-SSHHHHHHHHHHHHHTT-SEEEEESGSSCTCGSHH..HHHHCTTHHHHHHEEEESSHHHHHHHHCCC.TEEEEEESTT-SEGC...CS.. CS
  SpoU_methylase   5 vlveiedpgNlGaiaRtakafgaselvlvkprsadllnpe..akraaagalevlelkvvdsleealkelkee.gfalvatslkgksls...ei.. 91 
                     vl+++++ +N++ai+Rt+++fg+++l+++++    + +++   k +a ga +++++k++++ +e++kelke+ ++++++ts+++ +     +   
      EFC36964.1  51 VLEDVQSSQNVSAIIRTVECFGMNDLHIISNPDS-MSDKKgiSKGVAKGATDWINIKQYQNSDECFKELKEKhNCRIIVTSPYSIPQLvlgQKrn 144
                     89*************************9986544.45555457889************************9977******995554332441134 PP

                     ................................HHH............TTEEEEEEBTTTBS-HHHHCTSSEEEE----TTSSS--HHHHHHHHHH CS
  SpoU_methylase  92 ................................dlk............ekvalvfGnEdkGlsnelleladrlvkIpmsgeveSLNvavAvailly 142
                                                     +              +++a+vfGnE++G+sn+++++ad  ++Ip +g +eS+Nv+v++a+  y
      EFC36964.1 145 swredqhpsvynnlrdeiterhvrvphyigieN-VpidllnsdndydKPIAVVFGNESHGISNSAIDHADASLTIPLYGFTESFNVHVSTALTTY 238
                     445555566566566656666565555555550.0555556666666********************************************9877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.27s 00:00:00.71 Elapsed: 00:00:00.43
# Mc/sec: 2122.55
//
Query:       EFC36965.1  [L=712]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (712 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       726  (0.0404931); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 4650.25
//
Query:       EFC36966.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 2165.82
//
Query:       EFC36967.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.1e-33  114.0  10.7    4.4e-33  113.6  10.7    1.2  1  DUF1304   Protein of unknown function (DUF1304)


Domain annotation for each model (and alignments):
>> DUF1304  Protein of unknown function (DUF1304)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.6  10.7   2.5e-37   4.4e-33       2     109 ..      32     136 ..      31     137 .. 0.95

  Alignments for each domain:
  == domain 1  score: 113.6 bits;  conditional E-value: 2.5e-37
     DUF1304   2 lvallhlyilvlEmflwtsprarkvfgltkeeaakttkvlaanqGlYNgfLAagliwglllgseavglalvlfflgcvvvaglygaltaskkillvQgl 100
                 +vallh+++l+lEmflwt+p +r++ g+++++a+ t +vlaanqGlYNgfLA+gliw+++  s+++ ++l+lfflgc+v+ag++ga+t s  il +Q++
  EFC36967.1  32 FVALLHVFFLILEMFLWTTPFGRQISGFPEAFAQMT-QVLAANQGLYNGFLAMGLIWSIF--SKQFYFELQLFFLGCIVIAGIFGAATGSIAILGIQAA 127
                 89**************************99999888.**********************6..5779********************************* PP

     DUF1304 101 pallAlvll 109
                 pal+ l ++
  EFC36967.1 128 PALVVLHVV 136
                 ****99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       937  (0.0522617); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1215.60
//
Query:       EFC36968.1  [L=300]
Description: small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-19   70.4   0.0    2.6e-19   69.4   0.0    1.5  1  Ras       Ras family
    1.6e-06   28.3   0.0    6.2e-06   26.4   0.0    1.9  2  Roc       Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.4   0.0   2.9e-23   2.6e-19       1     141 [.      96     260 ..      96     278 .. 0.87

  Alignments for each domain:
  == domain 1  score: 69.4 bits;  conditional E-value: 2.9e-23
                 EEEEEESTTSSHHHHHHH........HHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHH.TH CS
         Ras   1 KlvlvGdsavGKtslllr........fvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfe.nv 90 
                 K+++vG+ ++GKts+l++        + +   + +y + i  d y++++ + ++ +++  wDT G+ e+k+lr+l+y ++++++l++d  s +s++  +
  EFC36968.1  96 KFMVVGS-SCGKTSFLYHlslglhppYSNVASNLQYLPSI-HDGYSTNLIFGSSFCNIGFWDTSGKSEYKTLRPLSYPGTDVCFLCFDCMSYDSLDlAI 192
                 6788885.69****99973333333355556677999***.9*****************************************************9346 PP

                 HHHHHHHHHHST...TTSEEEEEEETTTGGG.............G-SS-HHHHHHHHHHHT.SEEEEE CS
         Ras  91 kkwveeikrvae...envpivLvGnKvDlee.............kravsteegeelakelg.lkflet 141
                 ++++ee++++++   +++pi+L+ +K Dl++             ++ ++ + ge++ak +g +++le 
  EFC36968.1 193 NTFLEELTSHMKqegKTFPIALLSTKHDLQQdrkevlklliskqQKPINSQLGERIAKAIGcVTYLES 260
                 6*********9999999********************************************9999996 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.32   2.9e+03      10      42 ..      25      57 ..      22      75 .. 0.55
   2 !   26.4   0.0   6.9e-10   6.2e-06       1     119 [.      96     220 ..      96     221 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.32
                SSHHHHHHCHCT-CCC-EEETTTTEEEEEEECG CS
         Roc 10 vGKtsllkrfvedkfsekekstigvdfltkevt 42
                +GK  l + f +  f++ ++  +  d+ ++ ++
  EFC36968.1 25 AGKLALSSDFRKLYFEQMREYYLRSDMNEQALV 57
                566666666666666666666666666555443 PP

  == domain 2  score: 26.4 bits;  conditional E-value: 6.9e-10
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTB..TTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHH.... CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvend..kkvkkvklniWDtaGqerfrslhplylreaalailvydsrsse.... 93 
                 K ++vG  + GKts+l ++  +   + ++    +++l +     +g++++     + +++ +WDt+G+ ++++l+pl + + ++++l++d  s++    
  EFC36968.1  96 KFMVVGS-SCGKTSFLYHLSLGLHPPYSNVASNLQYLPSIH---DGYSTNliFGSSFCNIGFWDTSGKSEYKTLRPLSYPGTDVCFLCFDCMSYDsldl 190
                 7788886.57********99999988888888888877533...2332221123345999******************************555441112 PP

                 CHHHHHHHHHHHCSSS....-EEEEEE-TT CS
         Roc  94 nlkeWlkelkkvagks....pvilvgnkiD 119
                  +++ l+el+++++++    p+ l+ +k D
  EFC36968.1 191 AINTFLEELTSHMKQEgktfPIALLSTKHD 220
                 456777777666544322238888888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       775  (0.0432261); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.23s 00:00:00.72 Elapsed: 00:00:00.40
# Mc/sec: 2243.21
//
Query:       EFC36969.1  [L=284]
Description: hypothetical protein NAEGRDRAFT_82069 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (284 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       498  (0.0277762); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1784.64
//
Query:       EFC36970.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.9e-09   37.3   0.1    6.1e-08   33.8   0.1    2.3  1  ADH_zinc_N_2  Zinc-binding dehydrogenase
     0.0039   17.2   0.0     0.0074   16.3   0.0    1.4  1  ADH_zinc_N    Zinc-binding dehydrogenase


Domain annotation for each model (and alignments):
>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.8   0.1   6.8e-12   6.1e-08       1     133 []       1     172 [.       1     172 [. 0.66

  Alignments for each domain:
  == domain 1  score: 33.8 bits;  conditional E-value: 6.8e-12
                   TT-SEEEETTSTTHH..................HHH-TT-EEEEEES-H.HHHH.HHHHHHE....EEEEE.EEE--.--................. CS
  ADH_zinc_N_2   1 lGAdevidyrtedfe..................aatggegvDvvldtvg.gealleaslkvl....pggGr.lvsig.gpp................ 56 
                   +GAd vidy++++ +                  ++ g   vD+vld+vg +e +++++++      +  G  + +i+ + +                
    EFC36970.1   1 MGADVVIDYTKTSSKpridgesenlksicqtikEDHGDSYVDIVLDCVGgTEMYYRDVCNNFeckkARDGVaFTTISpN-Vpfepnmglsslmkigy 96 
                   59********999999*************99975555688*********855555666543345464447746777744.26999999999988864 PP

                   ..S-EEE-CHHHCTTT-EEEE--GGG...-.-HHHHHHHHHHH.HHHH--...--EEEEEEGGG..HHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  57 ..lsaallkpakkrkgrsvkyeflfsmkasaqadileelaali.eeGklr...pvvdrvfplee..aaeAhrylesgrarGKiVl 133
                     +s++++      +++  +++f+f m ++  +d ++ l++ i  ++++    p    +f++++  +++Ah+++es r++GKiV+
    EFC36970.1  97 fvVSNKIRS----LSSAYPSFHFVF-MDKN-VKD-MNLLMNHIvISNQVYnqlPLM--EFEFSAqgLNDAHKQMESQRTVGKIVI 172
                   433333333....333444455555.5566.566.444444321333332111333..35555566******************7 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   8.3e-07    0.0074      33      69 ..       1      50 [.       1      58 [. 0.80

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 8.3e-07
                TTESEEEET.............TTC.HHHHHHHHHTTTSSEEEEEESSCSH CS
  ADH_zinc_N 33 lGadeviny.............kea.dlverikeltggegvdvvfecvGsg 69
                +Gad+vi+y             ++  ++ + ike  g+  vd+v++cvG g
  EFC36970.1  1 MGADVVIDYtktsskpridgesENLkSICQTIKEDHGDSYVDIVLDCVG-G 50
                7********999888888877655555777777777999**********.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       459  (0.025601); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.27s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 1257.62
//
Query:       EFC36971.1  [L=710]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.5e-24   83.6   9.4    1.6e-05   24.7   0.1    6.1  5  NHL             NHL repeat
    7.1e-11   42.3   0.4      2e-10   40.9   0.4    1.8  1  BTB             BTB/POZ domain
    1.3e-06   28.6   1.8          9    6.7   0.0    6.4  6  Linker_histone  linker histone H1 and H5 family
  ------ inclusion threshold ------
      0.025   14.1  21.3        3.8    7.1   0.6    6.2  5  Plasmo_rep      Plasmodium repeat family
       0.16   12.0   0.5        7.8    6.6   0.0    3.9  5  HP1451_C        HP1451 C-terminal domain


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   0.0   6.2e-05      0.22       3      27 ..      10      34 ..       8      35 .. 0.83
   2 !   24.7   0.1   4.5e-09   1.6e-05       1      27 [.     108     134 ..     108     135 .. 0.96
   3 !   17.6   0.1   8.2e-07    0.0029       1      26 [.     164     188 ..     164     190 .. 0.89
   4 !   12.3   0.1   3.7e-05      0.13       1      23 [.     219     241 ..     219     246 .. 0.88
   5 !   18.9   0.1   3.1e-07    0.0011       1      27 [.     275     301 ..     275     302 .. 0.94

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.2e-05
                SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrvqv 27
                +P +v v+sn+++++aD+ n+++++
  EFC36971.1 10 NPFSVFVSSNNEVFIADYSNQSIRK 34
                55566689*************9986 PP

  == domain 2  score: 24.7 bits;  conditional E-value: 4.5e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+ v v+sn+++y+aD++n+r+++
  EFC36971.1 108 LNYPRNVYVSSNNEVYIADFCNQRIRK 134
                 79***********************86 PP

  == domain 3  score: 17.6 bits;  conditional E-value: 8.2e-07
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n P+Gv v sn+++y+aD+ nh ++
  EFC36971.1 164 LNGPAGVFV-SNNEVYIADYSNHVIR 188
                 799******.8************665 PP

  == domain 4  score: 12.3 bits;  conditional E-value: 3.7e-05
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +++P+G+ v+sn+++y++D+ nh
  EFC36971.1 219 LYNPSGTFVSSNNEVYISDCFNH 241
                 689****************8888 PP

  == domain 5  score: 18.9 bits;  conditional E-value: 3.1e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P Gv v+sn+++y++D+ nhr+++
  EFC36971.1 275 LYSPLGVFVSSNNEVYISDCFNHRIRK 301
                 689**********************86 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.9   0.4   5.7e-14     2e-10       1     102 [.     538     638 ..     538     645 .. 0.84

  Alignments for each domain:
  == domain 1  score: 40.9 bits;  conditional E-value: 5.7e-14
                 HHHHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST...TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT- CS
         BTB   1 lnelresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk...eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqi 96 
                 l++l++ ++ +D+++++g++k +++hk vL+  S++F alf+s+   ++ +++    + +  + e +e++++++Y   +++   e++  lL +a + +i
  EFC36971.1 538 LESLFNDKKTSDIQIKMGEDKYLYCHKTVLSTTSTFFAALFESGssfSDFNNGI-FTPDESEDLELLEIIIKYCYGISFDN---EKISGLLDMAMKHEI 632
                 57899***************************************7443333332.34456677899*********887777...59************* PP

                 HHHHHH CS
         BTB  97 prlkka 102
                 + l++ 
  EFC36971.1 633 KYLVDY 638
                 *99875 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.015        52      42      69 ..      23      54 ..      12      59 .. 0.78
   2 ?    0.5   0.0      0.22   7.9e+02      44      66 ..      70      92 ..      61      96 .. 0.77
   3 !    6.7   0.0    0.0025         9      29      69 ..     115     151 ..     108     154 .. 0.82
   4 ?    0.8   0.0      0.19   6.7e+02      43      67 ..     180     204 ..     170     210 .. 0.78
   5 ?    3.9   0.0     0.019        70      41      67 ..     234     260 ..     225     266 .. 0.72
   6 ?    3.4   0.0     0.028     1e+02      41      69 ..     290     318 ..     280     321 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.015
  Linker_histone 42 f.ksllkkalkkgvekgelvqpkg...kGasG 69
                    f + + ++ ++k +++g +v + g   kG+sG
      EFC36971.1 23 FiADYSNQSIRKVLQNGNIVTIAGngdKGFSG 54
                    4477889***************9966667776 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.22
  Linker_histone 44 sllkkalkkgvekgelvqpkgkG 66
                     ++++ +kk +++g++v + g+G
      EFC36971.1 70 VFVSSIMKKILQNGTIVTIAGNG 92
                    46777889999999999998877 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0025
  Linker_histone  29 yikakykvvdvskfksllkkalkkgvekgelvqpkgkGasG 69 
                     y++++++v     ++ ++++ ++k +++g ++ + g+G++G
      EFC36971.1 115 YVSSNNEV----YIADFCNQRIRKVLQNGNIITIAGNGTKG 151
                     55555554....56788*******************88887 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.19
  Linker_histone  43 ksllkkalkkgvekgelvqpkgkGa 67 
                     + + ++ ++k  ++g++v + g+G 
      EFC36971.1 180 ADYSNHVIRKISQNGTIVTIAGNGK 204
                     5677999*************99664 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.019
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGa 67 
                      ++  +++ ++k +++g++v + g+G 
      EFC36971.1 234 YISDCFNHVIRKILQNGTIVTIAGNGK 260
                     4466799***************98663 PP

  == domain 6  score: 3.4 bits;  conditional E-value: 0.028
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGasG 69 
                      ++  +++ ++k + +g +v + g+G+ G
      EFC36971.1 290 YISDCFNHRIRKVLHNGNIVTIAGNGTPG 318
                     44567999***************999866 PP

>> Plasmo_rep  Plasmodium repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.2     0.041   1.5e+02       1      10 [.      17      26 ..      17      28 .. 0.83
   2 ?    4.6   0.1    0.0064        23       1       8 [.     117     124 ..     117     126 .. 0.86
   3 ?    4.1   0.2    0.0096        34       2      10 ..     173     181 ..     173     193 .. 0.87
   4 ?    7.1   0.6    0.0011       3.8       1      10 [.     228     237 ..     228     237 .. 0.92
   5 ?    7.1   0.6    0.0011       3.8       1      10 [.     284     293 ..     284     293 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.041
  Plasmo_rep  1 FsDnEvYspk 10
                +s+nEv++ +
  EFC36971.1 17 SSNNEVFIAD 26
                69****9966 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0064
  Plasmo_rep   1 FsDnEvYs 8  
                 +s+nEvY+
  EFC36971.1 117 SSNNEVYI 124
                 69*****8 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.0096
  Plasmo_rep   2 sDnEvYspk 10 
                 s+nEvY+ +
  EFC36971.1 173 SNNEVYIAD 181
                 9*****976 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0011
  Plasmo_rep   1 FsDnEvYspk 10 
                 +s+nEvY+++
  EFC36971.1 228 SSNNEVYISD 237
                 6*******97 PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.0011
  Plasmo_rep   1 FsDnEvYspk 10 
                 +s+nEvY+++
  EFC36971.1 284 SSNNEVYISD 293
                 6*******97 PP

>> HP1451_C  HP1451 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.38   1.4e+03       4      28 ..      19      43 ..      16      48 .. 0.85
   2 ?   -2.2   0.0       1.2   4.4e+03       9      28 ..      68      87 ..      65      92 .. 0.77
   3 ?   -2.8   0.0       1.9   6.7e+03       4      29 ..     119     144 ..     118     149 .. 0.77
   4 ?    6.6   0.0    0.0022       7.8       1      29 [.     171     199 ..     171     204 .. 0.90
   5 ?   -1.2   0.0      0.56     2e+03       4      28 ..     230     254 ..     228     259 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.38
                HHHHHHHHHHHHHHCCCCCTS-EEE CS
    HP1451_C  4 nQeemiesylksviekvkeegkaqt 28
                n e +i+ y ++ i+kv ++g++ t
  EFC36971.1 19 NNEVFIADYSNQSIRKVLQNGNIVT 43
                678899**************99988 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.2
                HHHHHHHHHCCCCCTS-EEE CS
    HP1451_C  9 iesylksviekvkeegkaqt 28
                i  +++s+++k+ ++g + t
  EFC36971.1 68 IGVFVSSIMKKILQNGTIVT 87
                55688899999999998877 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 1.9
                 HHHHHHHHHHHHHHCCCCCTS-EEEE CS
    HP1451_C   4 nQeemiesylksviekvkeegkaqtk 29 
                 n e  i+ + ++ i+kv ++g++ t 
  EFC36971.1 119 NNEVYIADFCNQRIRKVLQNGNIITI 144
                 56778888999999999999988875 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0022
                 HHHHHHHHHHHHHHHHHCCCCCTS-EEEE CS
    HP1451_C   1 FLknQeemiesylksviekvkeegkaqtk 29 
                 F+ n e  i+ y ++vi+k+ ++g + t 
  EFC36971.1 171 FVSNNEVYIADYSNHVIRKISQNGTIVTI 199
                 8999********************99885 PP

  == domain 5  score: -1.2 bits;  conditional E-value: 0.56
                 HHHHHHHHHHHHHHCCCCCTS-EEE CS
    HP1451_C   4 nQeemiesylksviekvkeegkaqt 28 
                 n e  i+   ++vi+k+ ++g + t
  EFC36971.1 230 NNEVYISDCFNHVIRKILQNGTIVT 254
                 5677888899999999999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (710 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       517  (0.028836); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.46u 0.22s 00:00:00.68 Elapsed: 00:00:00.37
# Mc/sec: 5721.53
//
Query:       EFC36972.1  [L=193]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   11.9   0.3       0.22   11.0   0.3    1.4  1  DUF4244   Protein of unknown function (DUF4244)


Domain annotation for each model (and alignments):
>> DUF4244  Protein of unknown function (DUF4244)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.3   1.2e-05      0.22      22      42 ..      52      72 ..      49      77 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.2e-05
     DUF4244 22 tlAAvafAavLykvvtsdsVr 42
                 lA  +++avLy vv+s sV+
  EFC36972.1 52 SLALFGIGAVLYGVVNSISVS 72
                68999************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (193 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       911  (0.0508115); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.24s 00:00:00.65 Elapsed: 00:00:00.39
# Mc/sec: 1481.77
//
Query:       EFC36973.1  [L=275]
Description: thymidine kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-65  220.1   0.3    2.2e-65  219.8   0.3    1.1  1  TK        Thymidine kinase


Domain annotation for each model (and alignments):
>> TK  Thymidine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  219.8   0.3   1.2e-69   2.2e-65       1     177 []      63     234 ..      63     234 .. 0.99

  Alignments for each domain:
  == domain 1  score: 219.8 bits;  conditional E-value: 1.2e-69
          TK   1 gsielilgpmfaGKsteLlrrvkryqlaekkvvvikaakdnRysegkvvthdgisleakksktssleeikeeleeedvdvvlvDEaqFfeqdivelsek 99 
                 g+i+li+g mfaGK++eLlrr +ryq+a+k++v++k+ +d+Rys+++v+thd ++++a    t+ le+i ++l    ++v+++DE+qFf+ d+ve++e 
  EFC36973.1  63 GQIQLIFGNMFAGKTSELLRRLRRYQYAQKETVLVKYINDDRYSKENVSTHDLVQQKAI--PTDRLEKIASQLLG--YHVIGIDEGQFFP-DLVEFCEA 156
                 79********************************************************9..************99..*************.******** PP

          TK 100 lanegkivivagLdtdFerklFenilkllalaekvkklkavCmkCgkkAsftkrlnkekeviliGgkekYvsvCrkcy 177
                  an gkiviv +Ld++F+rk F+n+l l+++ae+v+klkavCm+Cgk+A f+kr+++e++ ++iGg++kY++ Crkcy
  EFC36973.1 157 AANGGKIVIVSALDGTFQRKQFGNVLSLVPMAESVVKLKAVCMVCGKDAAFSKRITDEQQTEVIGGSDKYIATCRKCY 234
                 *****************************************************************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       733  (0.0408835); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1598.36
//
Query:       EFC36974.1  [L=350]
Description: ubiquitin carboxyl-terminal hydrolase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-13   49.1   0.0      1e-12   48.1   0.0    1.4  1  UCH       Ubiquitin carboxyl-terminal hydrolase
    5.6e-06   26.2   0.8    6.2e-05   22.7   0.5    2.0  2  UCH_1     Ubiquitin carboxyl-terminal hydrolase


Domain annotation for each model (and alignments):
>> UCH  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.1   0.0   1.1e-16     1e-12      13     235 ..      39     291 ..      34     316 .. 0.68

  Alignments for each domain:
  == domain 1  score: 48.1 bits;  conditional E-value: 1.1e-16
                 HHHHHHHHTSHHHH.HHHHTCHHCCSSTCCCCC-.TT.TTS.TTHHHHHHHHHHHHHHSH-CCEE--HHHHHHHHHHSGGGTSSSTCEHHHHHHHHHHH CS
                 xxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH  13 nsvlQcLfsipelr.dyllsleevkkesrnkkelnesnplgkkgelakalkdlfkellkskskavsPkklkktlsklaksfsgykqqDaqEflaflLdq 110
                  +++Q+L+++++   +yl ++    +++ ++       ++ ++ el  a+ ++ ++++   + + +P    ++l+ l ++ +++   D  E l++++d 
  EFC36974.1  39 EALVQVLAHLDPVVeQYLFKQ----QHDDHQ------IKSDERSELGVAFDRVCRSVWSLDQGSSEPVD-GSALGGLFPM-ESGISLDFVEALNIVVDA 125
                 577899999988888888882....222222......12233446888999999999944555556633.3666677776.788889999999999999 PP

                 HHHHHCC........................HCCCHHHHHHCCCTTSHHHHHH-EEEEE........................................ CS
                 xxxxxxx........................xxxxxxxxxxxxxxxxxxxxxxxxxxxx........................................ RF
         UCH 111 lhedlnr........................evaeekwkkhlkrndslitdlfegqlks........................................ 145
                 +  ++n                         +                          +                                        
  EFC36974.1 126 CRGNFNFckgmtsnwirsddcpicgcksaseR--------------------------Keefcsikvpsnqwkefeksgvlnlkevetiegyhcdvcsf 198
                 99999885555555555555555554444440..........................24444455555555555555555566666666777999999 PP

                 ......EEEEEEB-SEEEEEEESEEETEE...EEE--SEEB--SEEE-GGGBSS-BTTS-TCS-BEEEEEEEEEESCTTSEEEEEEEECTTTTEEEEEE CS
                 ......xxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH 146 ......klklkrlPeiLiihlkRfsynss...ksKlntkvefpeeldlssylaeekkkkteekkkYeLiavvvHsGslssGHYvayiknekngkWykyd 235
                       + +++++P+iLi+++ Rf ++ +     K n+  ++ ++ +l+ ++++++ +      +YeL+avv+H+G   sG Y  +  n++n +Wyk  
  EFC36974.1 199 skpaeiSRSISQAPQILILQMDRFCFDYEtfnVVKKNDFYKVYLNQQLKLLMENNSLE------SYELVAVVNHYGLQTSGSYGGFFLNPTNRRWYKVA 291
                 9999999*******************99977766777777777777776666644444......4*******************************975 PP

>> UCH_1  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.02   1.8e+02      13      48 ..      39      75 ..      32      94 .. 0.72
   2 !   22.7   0.5     7e-09   6.2e-05     145     292 ..     149     275 ..     130     289 .. 0.72

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.02
                xxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxx RF
       UCH_1 13 NslLQvlyfipplrnlalshlak.eckkehcLlcElg 48
                 +l+Qvl+++ p+ + +l+++++ + + ++    Elg
  EFC36974.1 39 EALVQVLAHLDPVVEQYLFKQQHdDHQIKSDERSELG 75
                699*******999966666663314444444445555 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 7e-09
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxx.xxxxxxx.... RF
       UCH_1 145 clkCgseksrksstlvldlkyPkpsnekkeakvtfasilkssler.ekttrawCekCkryqpteqrktvknlPpvLalnakle.eee.elelwkt.... 236
                 c  C+s ++rk+ + ++++  P  sn    + ++f++    +l++ e+ + + C+ C+  +p e  +++ + P++L+l++ ++  +  ++++ k+    
  EFC36974.1 149 CG-CKSASERKEEFCSIKV--P--SN----QWKEFEKSGVLNLKEvETIEGYHCDVCSFSKPAEISRSISQAPQILILQMDRFcFDYeTFNVVKKndfy 238
                 44.7888899999999866..4..32....34567777777777746777899****************************998774133333333333 PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1 237 knwlpleiklsldedknleeklkeerekakaekeikvYeLqsvvvhigdskesghL 292
                 k +l++++kl                    ++++   YeL++vv h g ++ sg +
  EFC36974.1 239 KVYLNQQLKL------------------LMENNSLESYELVAVVNHYGLQT-SGSY 275
                 3344444444..................444567899*********99444.6655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2223.52
//
Query:       EFC36975.1  [L=289]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.083   12.8   0.0        0.2   11.6   0.0    1.7  1  F-box-like      F-box-like
       0.11   12.0   0.4        0.2   11.2   0.4    1.3  1  Carbam_trans_C  Carbamoyltransferase C-terminus


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   2.2e-05       0.2       3      33 ..      30      60 ..      28      70 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.2e-05
  F-box-like  3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrr 33
                +LP E +  I++y   sd l+l  +C+++++
  EFC36975.1 30 DLPSEMIGNILDYSLISDGLSLVTTCKQFHN 60
                8************6688************96 PP

>> Carbam_trans_C  Carbamoyltransferase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.4   2.2e-05       0.2      73     127 ..      71     126 ..      51     129 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.2e-05
  Carbam_trans_C  73 espymllvakvkeek.reeipavtHvDgtaRvqtvkkeanpryhelleafekltgv 127
                     + +ym l+a++++ + + + +a+tH+    R++ + +++++++  +l+ ++k+ g 
      EFC36975.1  71 PCKYMKLMANMTPYQlKLHHKAATHMKDQMRAKEIYENEKKKFKCMLKLIKKEIGK 126
                     356******999865277899***************************99998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (289 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1338  (0.0746277); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1876.04
//
Query:       EFC36976.1  [L=507]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       945  (0.0527079); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.27s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 3173.82
//
Query:       EFC36977.1  [L=1260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.6e-50  169.6   2.8    1.3e-49  168.6   1.4    2.3  2  DNA_ligase_A_M  ATP dependent DNA ligase domain
    7.3e-29  101.3   2.9    3.4e-28   99.1   2.9    2.3  1  DNA_ligase_A_N  DNA ligase N terminus
    8.8e-17   61.3   0.0    2.8e-16   59.7   0.0    1.9  1  Pkinase         Protein kinase domain
      8e-13   48.8   0.0    2.5e-12   47.3   0.0    1.9  1  DNA_ligase_A_C  ATP dependent DNA ligase C terminal region
    4.8e-11   42.7   0.8    4.6e-10   39.6   0.0    3.1  2  GST_C_3         Glutathione S-transferase, C-terminal domain
    8.8e-09   35.9   0.6    3.2e-08   34.1   0.6    2.0  1  RNA_ligase      RNA ligase
    0.00024   21.3   0.0     0.0012   19.1   0.0    2.2  1  GST_C           Glutathione S-transferase, C-terminal domain
    0.00026   20.4   0.0    0.00064   19.1   0.0    1.6  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0059   16.9   0.0     0.0059   16.9   0.0    2.8  2  GST_N           Glutathione S-transferase, N-terminal domain
  ------ inclusion threshold ------
        0.2   11.0  59.0       0.35   10.2  19.8    2.5  2  SDA1            SDA1
       0.39   10.8   3.4       0.84    9.8   0.1    3.1  4  TfoX_C          TfoX C-terminal domain
        2.7    6.2  43.5        1.8    6.8  22.0    2.2  2  CDC45           CDC45-like protein
        3.5    7.5  11.0        1.1    9.2   3.3    2.3  2  Velvet          Velvet factor
        3.9    6.2  33.6        2.4    6.9  13.5    2.5  2  Apt1            Golgi-body localisation protein domain
        5.7    7.3  61.0        1.9    8.9  29.0    2.4  2  DUF4604         Domain of unknown function (DUF4604)
        9.5    4.9  32.9        3.1    6.5   7.5    2.2  2  Presenilin      Presenilin


Domain annotation for each model (and alignments):
>> DNA_ligase_A_M  ATP dependent DNA ligase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.6   1.4   1.2e-52   1.3e-49       1     204 []     340     542 ..     340     542 .. 0.92
   2 ?   -1.7   0.0       1.7   1.9e+03      38      61 ..     651     674 ..     646     687 .. 0.84

  Alignments for each domain:
  == domain 1  score: 168.6 bits;  conditional E-value: 1.2e-52
                     -EEEEEESCHHHHHHHTTTSEEEEEEEESSEEEEEE..EETTEEEEEETTS-B-GG.GCHHHHHHHHHHBSTTESEEEEEEEEEEEETTTTCBEH CS
  DNA_ligase_A_M   1 pmLAeslksiekalkkleekafivEiKyDGeRaqvh..kegdkvklfSRrlkdita.akpelvkalkeafkkdeksvilDGElvavdketgeilp 92 
                     pmLA + k++ +++ ++  + f+ E+KyDGeR+q+h  +++d++k+fSR+lkd+ + + +++ k +++a+k++++svilDGE++++d++t++ilp
      EFC36977.1 340 PMLARPSKTYDDVIARC-PNGFYSELKYDGERIQIHydRKNDEIKYFSRNLKDVQEyKIKSVKKYISKAIKEKVESVILDGEILMMDTKTNKILP 433
                     9***************9.9*****************54499**************956677788899**************************** PP

                     HHHHCHHHHCHCCTHHHHHHSEEEEEEEEEEEETTEEHTTSCHHHHHHHHHHHB--BTTTEEE--EEEESSHHHHHHHH.....HHHHHTTECEE CS
  DNA_ligase_A_M  93 fqklasrkkkkkkveeklkeaelclfvFDiLyldgesltdeplkeRrklLeeilkesedrvelaeslevkdveeleell.....eeaiseglEGl 182
                     f++l +++++++k       a + +f+FDiLy++g+sl+  pl +R++l+++i++++++rv l e l+vk +++ +e++     + +i++g EGl
      EFC36977.1 434 FGTLGKNVRQDHK------DAVTTIFLFDILYYNGKSLLSVPLYKRKALMTKIVNPIKHRVMLGEYLVVKGSKQTREAIvsaemSAMIKKGEEGL 522
                     *******999994......55679*********************************************999988877522222678******** PP

                     EEEETT-CC-TTCEEEEEEEEE CS
  DNA_ligase_A_M 183 vvKnpdskYepgkrsknwlKvK 204
                     v+K+  s+Yep  r  +wlK+K
      EFC36977.1 523 VLKDLCSPYEPNAR--HWLKMK 542
                     **************..*****9 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.7
                     ETTEEEEEETTS-B-GGGCHHHHH CS
  DNA_ligase_A_M  38 egdkvklfSRrlkditaakpelvk 61 
                     +g+++++ SR+ ++i+ ++p+++k
      EFC36977.1 651 QGAEFSVSSRKDRPISVRFPRVTK 674
                     6899***************99987 PP

>> DNA_ligase_A_N  DNA ligase N terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.1   2.9     3e-31   3.4e-28       2     173 .]      17     182 ..      16     182 .. 0.92

  Alignments for each domain:
  == domain 1  score: 99.1 bits;  conditional E-value: 3e-31
                     CHHHHHHHHHHCC.---HHHHHHHHHHHHHTS-..SHHHHHHHHHHSS-CCCS------HHHHHHHHHHHHT--HH.HHHHHHHHHS-HHHHHHH CS
  DNA_ligase_A_N   2 FaelaelfekieestkkrlekrailanffrkvesagpedlypalrLllPdydgreygigesllakalaealglskk.kikdalakvgDlgevaee 95 
                     F+e+++l++ iee  ++ +ek++++++f+++++  g  d+y + +Ll+++  +r++++++++l+ ++a a+g + + +i++ +++ gD++e++++
      EFC36977.1  17 FSEFVALCKDIEE-VSAHTEKSQVMKEFLSDFK--G--DVYLLYKLLFAKENQRKFNLKDKKLVDVCASAFGEDLDeMIDH-MDSKGDVSETLKK 105
                     9************.55678**********9986..4..6*********************************999945555.6677********* PP

                     HHCCHHHH------BHHHHHHHHHHHHH-STTHHHHHHHHHHHHHHH.S-HHHHHHHHHHHCT---SS--HHHHHHHHH CS
  DNA_ligase_A_N  96 vlskrstlakkspltieevnelLdklaaagkgsedekkkilkkllkr.aspeEakyliriilkdlriglsektvldala 173
                     +l ++  +++k+ +t+++v+++L++l+  + ++++++++++kk+++  ++ +E+k+++rii kdl+i ++ k +l al+
      EFC36977.1 106 YLVRSDHARDKGIVTLKQVDDFLEELT--QLSKKEDQIRAFKKFVNDkLTGDELKFICRIICKDLKIRAGPKYLLAALH 182
                     **************************8..5556999********99889*****************************9 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.7   0.0   2.5e-19   2.8e-16     158     263 ..     982    1085 ..     962    1086 .. 0.80

  Alignments for each domain:
  == domain 1  score: 59.7 bits;  conditional E-value: 2.5e-19
                  TSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS-HHHHHHHHHHT-SSGCCST CS
     Pkinase  158 vgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeaseiseeakdllkkllkkdpkkRl 253 
                      +Y  PE+l ++ y+++vDv++lGv+ly++l+g+ pf+g ++k     +  ++    ++ g +   + +  ++is+ +kdll+++l+++ +kR+
  EFC36977.1  982 SKNNNYACPELLLKKAYGSEVDVYALGVLLYKILFGCFPFRGAQQKL---LMHFTVPLKDDVNGdDAMGSDDCGQNISKCCKDLLHNILEVNCEKRF 1075
                  45679************************************554444...222233334455555556677788999******************** PP

                  THHHHHTSGG CS
     Pkinase  254 taeellqhpy 263 
                  +++++++h++
  EFC36977.1 1076 SIQDIKNHQW 1085
                  *********9 PP

>> DNA_ligase_A_C  ATP dependent DNA ligase C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.3   0.0   2.2e-15   2.5e-12       2      99 .]     568     679 ..     567     679 .. 0.75

  Alignments for each domain:
  == domain 1  score: 47.3 bits;  conditional E-value: 2.2e-15
                     GGSEEEEEEEEEE..TTEEEEEEEE-SS--HHHHHHHHHHHG...GGEECTTCE...SS---HHHHTT..EE.E-.TT-EE..EEEESEEECTSS CS
  DNA_ligase_A_C   2 gglvgslllgvyd..dgkleyvgkvgtGfsdaeleelrkklk...elerkkppf...aekvpeeekrd..vW.ve.Pelvv..eVkfaeitasgk 82 
                     ggl++ +++g  d   gk++ ++k+g+G +d+++e+l+++lk   +   k+p++       + ++++    + v+ P+++v  e+++ae++ s +
      EFC36977.1 568 GGLMSVFMMGSFDkkLGKWRIICKCGNGHDDQTIETLNEELKsnmKRISKDPSLvpdD--IDIHTNALvpDFiVKdPKKSVvwEIQGAEFSVSSR 660
                     78999********98999***********************98873333444443431..22222222344443346544355**********97 PP

                     STT..EECT-EEEEE-TTS CS
  DNA_ligase_A_C  83 yka..slRfPrfkrlReDk 99 
                      +   s+RfPr++++R+Dk
      EFC36977.1 661 KDRpiSVRFPRVTKIRDDK 679
                     7779**************8 PP

>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1       2.1   2.4e+03      10      42 ..     373     410 ..     369     419 .. 0.72
   2 !   39.6   0.0   4.1e-13   4.6e-10       4      88 ..    1163    1247 ..    1160    1258 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 2.1
                 CCCSHCHHH.....HHHHHHHHHHHHCHHHHHHHHHHC CS
     GST_C_3  10 llydqkeea.....ekkkefleerlpkflkyfekvlkk 42 
                 ++yd k+ +     ++ k++ e +++ + ky++k++k+
  EFC36977.1 373 IHYDRKNDEikyfsRNLKDVQEYKIKSVKKYISKAIKE 410
                 55633433345678889999999999999999998883 PP

  == domain 2  score: 39.6 bits;  conditional E-value: 4.1e-13
                  HHHHHCCCC...SHCHHHHHHHHHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHHTCCCC-HHHHHHHHHHHT CS
     GST_C_3    4 hhpiaklly...dqkeeaekkkefleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleeaealkkfpklkalyervea 88  
                    ++++++y   +++e++e+ k+f+e +l+++++ ++++l   + gy++ + lT+ADl+l++++ +le++++ +++ +lk+    + +
  EFC36977.1 1163 LLEFFRVFYeicNETEKEEELKKFKEGTLQRVFSGLNNLLNGTKCGYFIEGMLTWADLFLLEIVLNLESVGIANEYQRLKQI---LME 1247
                  567888899886666666***********************88889************************777888888875...334 PP

>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.1   0.6   2.8e-11   3.2e-08       6     161 .]     363     542 ..     359     542 .. 0.66

  Alignments for each domain:
  == domain 1  score: 34.1 bits;  conditional E-value: 2.8e-11
                 EEE-SSEEEEEEEETT...EEEEETTCEBCTTTHHHHHHTHHHHHHHHHHHHH....ECCEEEEEEEES......SS........TTSS.......... CS
  RNA_ligase   6 tEKlDGtnfriylvke...vgvasRsqilpfgeekfkefkrwaaalrkklkekla..neelilyGElig.....hsi......kygglpk......... 79 
                 + K DG++++i+++++   ++++sR+    ++e       ++ +  +k++ + ++  +e++il GE++      ++i            k         
  EFC36977.1 363 ELKYDGERIQIHYDRKndeIKYFSRNLKD-VQE-------YKIKSVKKYISKAIKekVESVILDGEILMmdtktNKIlpfgtlG-----Knvrqdhkda 448
                 67************55578*******888.333.......44444555555555566778*********877765557555441.....1334444788 PP

                 ..EEEEEEEEEEECTTBECE--HHHHHHHHHCCT....B..EEEEE.SS.HHHHHCCC.........HHHHTC--EEEEEESSSSBE.TTEBSEEEEE CS
  RNA_ligase  80 ..efyvFdifdirdkeeqrylspdevealakglg....tvpvlyegkfl.aaeellel........llskgnkrEGlVikpeselyk.nkgraifKvk 161
                    +++Fdi+  ++ ++   ++  +++al +++     +  +l+e+ +  ++++ +e         +   ++  EGlV+k+  + y+ n  r+++K+k
  EFC36977.1 449 vtTIFLFDILYYNG-KSLLSVPLYKRKALMTKIVnpikHRVMLGEYLVVkGSKQTREAivsaemsaM--IKKGEEGLVLKDLCSPYEpNA-RHWLKMK 542
                 99********9873.3555556666655555443455444445444444444444444777765442..34589*******999999775.*****97 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0     1e-06    0.0012      13      73 ..    1173    1235 ..    1131    1244 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 1e-06
                  HSTTHHHHHHHHHHHHHHHHHHHHHHHHHHH..TSSSSSTTSSCHHHHHHHHHHHHHHHHTTT CS
       GST_C   13 yvkaeekkeelvdealekvaevlsaleeelk..kqdylvGdkltlADialvpilnwlqrlgla 73  
                  ++++ ek+eel++ ++  + +v+s l++ l   k +y++   lt+AD+ l++i++ l+++g+a
  EFC36977.1 1173 ICNETEKEEELKKFKEGTLQRVFSGLNNLLNgtKCGYFIEGMLTWADLFLLEIVLNLESVGIA 1235
                  4556699999*******************************************9999988876 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   5.7e-07   0.00064     146     217 ..     961    1032 ..     952    1083 .. 0.71

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 5.7e-07
                   STTTHEETTTSSEE.EETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHH CS
  Pkinase_Tyr  146 DfGLardiekddey.vkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypglkneevlek 217 
                     G a  i+++d+  +++ ++  + ++  pE l +k + s+ Dv++ Gvll+ i+  g  p++g +++ ++++
   EFC36977.1  961 NKGFAVFIYTKDRDdKDRVNESKNNNYACPELLLKKAYGSEVDVYALGVLLYKILF-GCFPFRGAQQKLLMHF 1032
                   55666667555554377888889999****************************98.9999999988776654 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   5.2e-06    0.0059      43      76 .]    1099    1136 ..    1086    1136 .. 0.89
   2 ?   -0.2   0.1       1.2   1.3e+03      13      49 ..    1151    1187 ..    1145    1194 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 5.2e-06
                  HHHHHHCTT...S-SSEEEET.TEEEESHHHHHHHHHH CS
       GST_N   43 pellklnpl...gkvPaLedn.gkkltESraIleYiar 76  
                  + +++ +p+   g++P+L +  ++ + ++ aI++Y+a+
  EFC36977.1 1099 KSWKNHKPFtryGQLPYLKVSdDFHVYQTLAIARYLAQ 1136
                  579999999*********9988**************96 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.2
                  THHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHC CS
       GST_N   13 rahrirlllaakgveyevvpldfeageekspellkln 49  
                  +++ + + l +  +e+  v+++  +  ek++el+k +
  EFC36977.1 1151 LTEEVVASLNEVLLEFFRVFYEICNETEKEEELKKFK 1187
                  5666777788999999999999988888889999865 PP

>> SDA1  SDA1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2  19.8   0.00031      0.35      76     190 ..     225     323 ..     208     402 .. 0.55
   2 ?    5.9  31.2    0.0063       7.1     111     202 ..     710     801 ..     674     821 .. 0.50

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00031
        SDA1  76 lekwkeeekkekreeeeed.sddeddeedwevesdddseedseggwidvesdeeeieesdesedeeeeeeeeeekeekeeeeeeeeeeeeeeeeeeeee 173
                 +++++++++  +   +  + sddedd++++   s+ +s++d+ ++ id ++++++ + sd ++d++ +e ++ +++ ++ ee+ ee   +ee+e+++++
  EFC36977.1 225 IKDADSDDEGTNF--DMMNiSDDEDDKKKKS--SKATSSNDK-KKTIDKKKSSKSSDNSD-KDDDSGDE-TDIGENVDDIEEKPEEL-VDEESEDDSKK 315
                 4443333333332..1112122222222211..111222233.44566666666555566.33333222.34444444444444421.11222222111 PP

        SDA1 174 ekekkkkkakeaseeek 190
                 +k++kk         + 
  EFC36977.1 316 KKKNKK---------AP 323
                 111111.........11 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0063
        SDA1 111 dseedseggwidvesdee..eieesdesedeeeeeeeeeekeekeeeeeeeeeeeeeeeeeeeeeekekkkkkakeaseeekkkekeeekiska 202
                 d  +ds ++ +dv+++++  +++ +++s+dee+e++++++k++++ +++ +++++e++e+++++ +k ++kkk+k++ +++ ++ ++++k++k+
  EFC36977.1 710 DAGDDS-DESVDVKDKKKrsRAK-KSKSDDEEDESDSSSKKKKNSRKKKINSSDDEDDEDDKKSAKKANDKKKSKSSDNSDGEDDDPKAKKAKK 801
                 333444.4448887777743222.2224444433333333333332222222222222222222222222222222222333333333333332 PP

>> TfoX_C  TfoX C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.8     2e+03       7      20 ..     207     220 ..     205     230 .. 0.81
   2 ?    9.8   0.1   0.00075      0.84      53      79 ..     935     961 ..     917     962 .. 0.85
   3 ?   -3.0   0.1       7.5   8.4e+03      61      80 ..    1080    1099 ..    1080    1099 .. 0.89
   4 ?   -2.3   0.0       4.4   4.9e+03      29      45 ..    1228    1244 ..    1224    1253 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.8
      TfoX_C   7 dLpNlglklerlLk 20 
                 dL+Nl+++ ++lL 
  EFC36977.1 207 DLKNLSMTAQSLLD 220
                 9*******999995 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00075
      TfoX_C  53 lLyaLegAlqgvhwndlpeeekeeLle 79 
                  Ly L+ A++g  wn +++  ke+L +
  EFC36977.1 935 HLYRLHHAISGLDWNRVEQLLKENLSN 961
                 49*********************9986 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 7.5
      TfoX_C   61 lqgvhwndlpeeekeeLlek 80  
                  +++ +w+ + +++k +Llek
  EFC36977.1 1080 IKNHQWYKIGKTQKVDLLEK 1099
                  67899**********99985 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 4.4
      TfoX_C   29 eLrelGaveaylkiket 45  
                  +L+++G  + y+++k+ 
  EFC36977.1 1228 NLESVGIANEYQRLKQI 1244
                  68999999999999986 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0  13.5    0.0053       5.9     106     197 ..     242     321 ..     196     387 .. 0.50
   2 ?    6.8  22.0    0.0016       1.8      99     195 ..     698     802 ..     678     845 .. 0.44

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0053
       CDC45 106 vfDDgdieeeleeereayealeeeeesdeedeeeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdeeee......................sd 182
                 + DD+d  ++ +++ +a  + ++++  d                               +++++k++++sd++++                      ++
  EFC36977.1 242 ISDDED--DKKKKSSKATSSNDKKKTID-------------------------------KKKSSKSSDNSDKDDDsgdetdigenvddieekpeelvDE 307
                 222222..11111222222222222221...............................1111111122222222222222222221111122223211 PP

       CDC45 183 dddersrkrrrseps 197
                 ++++ s+k+++++ +
  EFC36977.1 308 ESEDDSKKKKKNK-K 321
                 1112222222222.1 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0016
       CDC45  99 eekerivvfDDgdi......eeeleeereayealeeeeesdeedeeeeeeddddeeeee.eeeedeedeeedeeeskkkrksksdeeee.sddddersr 189
                 ++k+ + +f D d       + +++++++   a +++++++e+++++++++++++++++ ++++de+de+++++ +k ++k+ks+++++ + +dd++++
  EFC36977.1 698 NRKGLVPIFGDADAgddsdeSVDVKDKKKRSRAKKSKSDDEEDESDSSSKKKKNSRKKKiNSSDDEDDEDDKKSAKKANDKKKSKSSDNsDGEDDDPKA 796
                 555666677555541111113333333333333333322222222222222222222220222223333333333333333344444443444444444 PP

       CDC45 190 krrrse 195
                 k+ +++
  EFC36977.1 797 KKAKKS 802
                 444444 PP

>> Velvet  Velvet factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.9     0.097   1.1e+02      65     123 ..     249     321 ..     183     412 .. 0.62
   2 ?    9.2   3.3   0.00096       1.1      49     173 ..     682     829 ..     656     831 .. 0.56

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.097
                 SSSB--EE--.---------.-------------..............------------------------- CS
      Velvet  65 gtkevnlvkssssasssisseasssssqsseess..............sspksqassaessapsssaapsaqe 123
                 ++k+ +  +ss+++++ i +++ss ss +s + +              +++k+++ ++e+s+  s++++++++
  EFC36977.1 249 KKKKSSKATSSNDKKKTIDKKKSSKSSDNSDKDDdsgdetdigenvddIEEKPEELVDEESEDDSKKKKKNKK 321
                 1111111122222222333333333333333333666777777655553333333333333333333332222 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00096
                 ---TTEEEEEEEEETTSSSB--EE.....................--.---------.....-------------.----------------------- CS
      Velvet  49 ldssffvvtvdLwsedgtkevnlv.....................kssssasssiss....easssssqsseess.sspksqassaessapsssaapsa 121
                 ld++++   ++L +e+ +k +  v                     k++s+a++s  s    ++s sss+++++s+  + +s+++ +++ +++s+++++ 
  EFC36977.1 682 LDHTNYQEIIKLKNESNRKGL--VpifgdadagddsdesvdvkdkKKRSRAKKSK-SddeeDESDSSSKKKKNSRkKKINSSDDEDDEDDKKSAKKAND 777
                 666666666777775544443..33367777777666666666652222222222.1344322333333333333212222222222333333333333 PP

                 ----------------------EESEEE--EEE-EEEE-TT--EEEEEE--- CS
      Velvet 122 qeekekkeatlssssnqasskltrnLiGslvasafrlkdpedkpgifFvfqD 173
                 +++++ ++++  ++ +++++k  ++ iG + + +   +d ++ + i+++  D
  EFC36977.1 778 KKKSKSSDNSDGEDDDPKAKKAKKSTIGIKLSDIDTINDSSTPEQIYYIYGD 829
                 3344455555555666669999**************9999999999998766 PP

>> Apt1  Golgi-body localisation protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6  12.0     0.011        12     308     423 ..     239     400 ..     223     418 .. 0.42
   2 ?    6.9  13.5    0.0021       2.4     323     400 ..     721     792 ..     678     871 .. 0.51

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.011
        Apt1 308 mvkess.seeddesdeesessssssssssssassssssssrssslelrlkpt.................sstssssssessssssskkrsseessless 388
                 m++    ++edd+++++s+++ss  ++++ ++++ss+ss++s++ +++  +t                 +++s      +++s+ +kk+++ +++++ s
  EFC36977.1 239 MMN--IsDDEDDKKKKSSKATSSNDKKKTIDKKKSSKSSDNSDKDDDSGDETdigenvddieekpeelvDEES------EDDSKKKKKNKKAPKKIKIS 329
                 222..22333333333333333322333333333333333333333333344677776666554333221111......11111222222222222222 PP

        Apt1 389 aservkssr............................................asddleemksRaskymtfayikipsv 423
                         +                                             + + +e+k  +++ + + + ki+sv
  EFC36977.1 330 --------TkmklfhpvkpmlarpsktyddviarcpngfyselkydgeriqihYDRKNDEIKYFSRNLKDVQEYKIKSV 400
                 ........12222333333444444455555555556666666666666666655555555555555555555555555 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0021
        Apt1 323 esessssss..ssssssassssssssrssslelrlk.pt..........sstssssssessssssskkrsseesslessaservkssrasd 400
                  ++++++s   +s+s++++++s+sss+++++++++k ++          +s+++++ +++s+ss  ++                    ++d
  EFC36977.1 721 VKDKKKRSRakKSKSDDEEDESDSSSKKKKNSRKKKiNSsddeddeddkKSAKKANDKKKSKSSDNSDG-------------------EDD 792
                 111111111212222222222222222222222211111122221111111111111111111111111...................111 PP

>> DUF4604  Domain of unknown function (DUF4604)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9  24.0     0.058        65      91     168 ..     246     329 ..     215     334 .. 0.45
   2 ?    8.9  29.0    0.0017       1.9      83     164 ..     713     803 ..     681     809 .. 0.45

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.058
     DUF4604  91 eaeediefkkpkkasi.kekasslaaksskkkkkgkvvgeedeeeed.............kskakkkekekkkakkkkkkkkkkkkkkklLS 168
                 e+    ++kk +ka++ ++k+++++ k+s+k       + +d+++++             ++k ++  +e++++++kkkkk kk+ kk++ S
  EFC36977.1 246 ED---DKKKKSSKATSsNDKKKTIDKKKSSKSS-----DNSDKDDDSgdetdigenvddiEEKPEELVDEESEDDSKKKKKNKKAPKKIKIS 329
                 11...1122222222222222222222222222.....111111111233445666766555555555666666666666666677777765 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0017
     DUF4604  83 eeeeeegeeaeediefkkpkkasikeka.....sslaaksskkkkkgkvvgeedeeeedkskakkkekekkkakkkkkk........kkkkkkkk 164
                 ++++e  + ++++++ +++k++s    +     s++++k++k+ +k+k+ +++de++ed++k +kk+++kkk k++ ++        +kk+kk++
  EFC36977.1 713 DDSDESVDVKDKKKRSRAKKSKS----DdeedeSDSSSKKKKNSRKKKINSSDDEDDEDDKKSAKKANDKKKSKSSDNSdgedddpkAKKAKKST 803
                 22222222222212222222222....12223344444444444445666666655555333333333333333333335566776433333333 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   7.5    0.0028       3.1     196     309 ..     208     321 ..     192     352 .. 0.48
   2 ?    4.0  17.4     0.016        18     235     324 ..     722     808 ..     704     815 .. 0.35

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0028
  Presenilin 196 LrlLvelaqerneeifpaLiYsatvvvlaaeekkaevaeseeeeeaekkkeeasesskeeeseeesseksaqsse..........seeeseeesseaes 284
                 L+ L  +aq+   +i  aLi +a+   + ++ + ++ + +e++++++++k+++s+++k++ ++++ss++s++s++                e+  + e+
  EFC36977.1 208 LKNLSMTAQSL-LDI-DALIKDADSDDEGTNFDMMNISDDEDDKKKKSSKATSSNDKKKTIDKKKSSKSSDNSDKdddsgdetdiG-----ENVDDIEE 299
                 55555555554.345.6777777777665555555544445555555555555555554444444444444444333222111120.....22222222 PP

  Presenilin 285 saeesseekeseessesseeeeeee 309
                 ++ee  +e++   +++s++++++++
  EFC36977.1 300 KPEELVDEES---EDDSKKKKKNKK 321
                 2222222222...222211111111 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.016
  Presenilin 235 seeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaeesseekeseessesseeeeeeeeeeeeseseergvkL 324
                 +++ ++++++k+++s +++e+es+++s++k+++++++ ++s++e  e+++++++++++k++++ss++s+ e+++ ++++  ++ + g+kL
  EFC36977.1 722 KDK-KKRSRAKKSKS-DDEEDESDSSSKKKKNSRKKKINSSDDEDDEDDKKSAKKANDKKKSKSSDNSDGEDDDPKAKK-AKKSTIGIKL 808
                 111.11222212222.222222222222222222222222222222222222222223333333333333333333333.2333458888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2533  (0.141279); expected 358.6 (0.02)
Passed bias filter:                      731  (0.0407719); expected 358.6 (0.02)
Passed Vit filter:                       260  (0.0145016); expected 17.9 (0.001)
Passed Fwd filter:                       104  (0.00580066); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 1.80u 0.40s 00:00:02.20 Elapsed: 00:00:00.61
# Mc/sec: 6215.11
//
Query:       EFC36978.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       569  (0.0317363); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2018.64
//
Query:       EFC36979.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.026   14.8   0.2      0.073   13.3   0.0    2.0  2  Ependymin  Ependymin


Domain annotation for each model (and alignments):
>> Ependymin  Ependymin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       0.3   5.3e+03       3      11 ..      66      74 ..      27      89 .. 0.61
   2 ?   13.3   0.0   4.1e-06     0.073      85     127 .]     221     261 ..     145     261 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.3
   Ependymin  3 kteqldvll 11
                +++++++l 
  EFC36979.1 66 QQYKFRTLS 74
                333333333 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 4.1e-06
   Ependymin  85 teegCipvsesfsteksgvvttsffdvtlgisdpnvFipPseC 127
                 ++e+ ip++++ ++++ g   t+++d+ +g sd n +++P++C
  EFC36979.1 221 KMEDRIPLRSTNQENDPG--ATDYVDFIIGQSDLNLYEIPKYC 261
                 456788888888888887..99********************* PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       882  (0.049194); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.35u 0.20s 00:00:00.55 Elapsed: 00:00:00.34
# Mc/sec: 2323.84
//
Query:       EFC36980.1  [L=669]
Description: hypothetical protein NAEGRDRAFT_82045 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.4e-21   73.1  28.5      4e-08   32.7   5.4    4.7  4  SHOCT           Short C-terminal domain
    0.00034   20.6   1.1        6.2    7.0   0.1    3.4  3  DUF1707         Domain of unknown function (DUF1707)
  ------ inclusion threshold ------
      0.033   14.2  19.9       0.18   11.8   1.7    3.7  3  GvpG            Gas vesicle protein G
        1.2    9.3   8.6        1.9    8.6   0.2    3.8  3  CARD            Caspase recruitment domain
        1.2    9.2  11.2        6.6    6.8   0.2    3.7  4  GlnD_UR_UTase   GlnD PII-uridylyltransferase
        7.5    6.8   7.7         27    5.0   0.9    3.8  2  Bac_small_YrzI  Probable sporulation protein (Bac_small_yrzI)


Domain annotation for each model (and alignments):
>> SHOCT  Short C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.7   2.5e-08   7.5e-05       1      28 []      10      37 ..      10      37 .. 0.97
   2 !    7.1   0.5    0.0015       4.6       1      19 [.     245     263 ..     245     272 .. 0.92
   3 !   32.7   5.4   1.3e-11     4e-08       1      28 []     311     338 ..     311     338 .. 0.98
   4 !   25.6   1.6   2.4e-09   7.3e-06       1      27 [.     372     398 ..     372     399 .. 0.95

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 2.5e-08
       SHOCT  1 daLekLkeLyarGeIteEEFeakKakLL 28
                +++++L++ +++G+ + E+Fe+ K+k+L
  EFC36980.1 10 EQIQILQSFLDQGLMDPEDFEEEKKKIL 37
                69*************************8 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0015
       SHOCT   1 daLekLkeLyarGeIteEE 19 
                 ++LekL+ L ++ +++e+E
  EFC36980.1 245 QQLEKLANLVESEILSEDE 263
                 69****************9 PP

  == domain 3  score: 32.7 bits;  conditional E-value: 1.3e-11
       SHOCT   1 daLekLkeLyarGeIteEEFeakKakLL 28 
                 ++L+kL++L+++G++t+EE+ akK++LL
  EFC36980.1 311 EQLQKLQDLLDAGILTDEEYKAKKRQLL 338
                 69*************************8 PP

  == domain 4  score: 25.6 bits;  conditional E-value: 2.4e-09
       SHOCT   1 daLekLkeLyarGeIteEEFeakKakL 27 
                 d+L kL++L+++G++ +EE+++kK++ 
  EFC36980.1 372 DQLSKLDSLLEQGILEQEEYDEKKRQV 398
                 89**********************986 PP

>> DUF1707  Domain of unknown function (DUF1707)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0    0.0022       6.4       3      37 ..       4      37 ..       2      44 .. 0.86
   2 ?    3.5   0.1     0.025        75      12      32 ..     313     333 ..     306     338 .. 0.85
   3 !    7.0   0.1    0.0021       6.2      12      37 ..     374     399 ..     366     400 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0022
     DUF1707  3 asdadReravelLrealaeGrLtldEfdeRleaal 37
                ++d++Re+ +++L+  l +G ++ ++f+e  +++l
  EFC36980.1  4 ITDEQREQ-IQILQSFLDQGLMDPEDFEEEKKKIL 37
                67999998.59*****************9877665 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.025
     DUF1707  12 velLrealaeGrLtldEfdeR 32 
                 ++ L++ l +G Lt +E+   
  EFC36980.1 313 LQKLQDLLDAGILTDEEYKAK 333
                 789***************865 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0021
     DUF1707  12 velLrealaeGrLtldEfdeRleaal 37 
                 +  L+  l++G L+ +E+de   +++
  EFC36980.1 374 LSKLDSLLEQGILEQEEYDEKKRQVM 399
                 4579999*************999987 PP

>> GvpG  Gas vesicle protein G
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   4.1     0.046   1.4e+02      34      63 ..       9      38 ..       5      50 .. 0.87
   2 ?   11.8   1.7   6.2e-05      0.18      24      63 ..     300     339 ..     291     355 .. 0.85
   3 ?    8.6   0.5   0.00062       1.9      34      61 ..     371     398 ..     366     413 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.046
        GvpG 34 rkeLaaLqqeLdaGeIdeeeFdrrEeelLd 63
                r ++  Lq  Ld+G +d e+F+++  ++L 
  EFC36980.1  9 REQIQILQSFLDQGLMDPEDFEEEKKKILS 38
                678889*********************996 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 6.2e-05
        GvpG  24 eeqlddqenlrkeLaaLqqeLdaGeIdeeeFdrrEeelLd 63 
                  ++ ++ ++++ +L +Lq  LdaG  ++ee+ ++  +lL 
  EFC36980.1 300 SKKSNSTATVEEQLQKLQDLLDAGILTDEEYKAKKRQLLP 339
                 556678899**************************99995 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00062
        GvpG  34 rkeLaaLqqeLdaGeIdeeeFdrrEeel 61 
                 r +L++L+  L++G  ++ee+d++  ++
  EFC36980.1 371 RDQLSKLDSLLEQGILEQEEYDEKKRQV 398
                 689*******************998776 PP

>> CARD  Caspase recruitment domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.6      0.37   1.1e+03      22      42 ..     250     272 ..     239     282 .. 0.69
   2 ?    3.0   0.1     0.035   1.1e+02      22      40 ..     316     334 ..     305     340 .. 0.85
   3 ?    8.6   0.2   0.00062       1.9      22      41 ..     377     396 ..     365     419 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.37
                 HHHHHHTTSS-HHHHHHHHT..S CS
        CARD  22 ldyLlekkVLteeeeekika..k 42 
                 l +L+e ++L+e+e    k+  +
  EFC36980.1 250 LANLVESEILSEDEVISKKEtlL 272
                 56799999999998655444433 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.035
                 HHHHHHTTSS-HHHHHHHH CS
        CARD  22 ldyLlekkVLteeeeekik 40 
                 l +Ll +++Lt ee+ + k
  EFC36980.1 316 LQDLLDAGILTDEEYKAKK 334
                 889************9876 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00062
                 HHHHHHTTSS-HHHHHHHHT CS
        CARD  22 ldyLlekkVLteeeeekika 41 
                 ld Lle+++L +ee+++ k 
  EFC36980.1 377 LDSLLEQGILEQEEYDEKKR 396
                 9***************9987 PP

>> GlnD_UR_UTase  GlnD PII-uridylyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       2.5   7.5e+03      55      78 ..       8      31 ..       6      34 .. 0.87
   2 ?    3.0   0.6     0.034     1e+02      57     106 ..     245     292 ..     236     303 .. 0.83
   3 ?    4.9   0.1    0.0087        26      54      80 ..     308     334 ..     298     338 .. 0.84
   4 ?    6.8   0.2    0.0022       6.6      54      82 ..     369     397 ..     362     417 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 2.5
  GlnD_UR_UTase 55 erstlealeelvergllteeeake 78
                   +r++++ l+   ++gl+++e+++e
     EFC36980.1  8 QREQIQILQSFLDQGLMDPEDFEE 31
                   789999999999999999999876 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.034
  GlnD_UR_UTase  57 stlealeelvergllteeeakelreayrflrrlehrLqlladrqthrLpf 106
                    ++le+l++lve ++l+e+e+  ++++++ lr+ +  L   ++r ++++ +
     EFC36980.1 245 QQLEKLANLVESEILSEDEV--ISKKETLLRQQRKKLEEERKRPSESMVT 292
                    68999************998..6788889999999888888888877765 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.0087
  GlnD_UR_UTase  54 rerstlealeelvergllteeeakelr 80 
                     ++++l++l++l ++g+lt+ee+k+ +
     EFC36980.1 308 TVEEQLQKLQDLLDAGILTDEEYKAKK 334
                    67889******************9765 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0022
  GlnD_UR_UTase  54 rerstlealeelvergllteeeakelrea 82 
                    ++r++l++l+ l e+g+l++ee++e +++
     EFC36980.1 369 QQRDQLSKLDSLLEQGILEQEEYDEKKRQ 397
                    89*********************998776 PP

>> Bac_small_YrzI  Probable sporulation protein (Bac_small_yrzI)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   1.0     0.032        95      17      43 ..     265     291 ..     263     293 .. 0.85
   2 ?    5.0   0.9     0.009        27       9      33 ..     293     318 ..     290     321 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.032
  Bac_small_YrzI  17 yseeEiereqqiekieeemkdrqlkYy 43 
                     +s+ E +  qq +k+eee k+  ++++
      EFC36980.1 265 ISKKETLLRQQRKKLEEERKRPSESMV 291
                     688999999*********998777775 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.009
  Bac_small_YrzI   9 TITIqKRk.yseeEiereqqiekiee 33 
                     T+T++K + +s  ++  e+q +k+++
      EFC36980.1 293 TTTVKKSSkKSNSTATVEEQLQKLQD 318
                     899999988***************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (669 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2587  (0.144291); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.94u 0.28s 00:00:01.22 Elapsed: 00:00:00.52
# Mc/sec: 3844.71
//
Query:       EFC36981.1  [L=401]
Description: hypothetical protein NAEGRDRAFT_82046 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.1e-09   36.3   0.0    1.1e-08   34.9   0.0    1.7  1  RWP-RK          RWP-RK domain
     0.0081   15.9   0.0      0.015   15.1   0.0    1.4  1  HTH_8           Bacterial regulatory protein, Fis family
  ------ inclusion threshold ------
      0.016   14.9   0.2      0.032   14.0   0.2    1.5  1  HTH_psq         helix-turn-helix, Psq domain
      0.021   14.6   0.0      0.041   13.7   0.0    1.4  1  HTH_23          Homeodomain-like domain
      0.036   14.1   0.1      0.073   13.1   0.1    1.5  1  HTH_3           Helix-turn-helix
      0.049   13.1   1.6      0.087   12.3   1.6    1.4  1  TRM13           Methyltransferase TRM13
      0.097   12.9   0.0       0.22   11.7   0.0    1.6  1  HTH_17          Helix-turn-helix domain
       0.15   12.1   0.2       0.42   10.7   0.2    1.7  1  HTH_7           Helix-turn-helix domain of resolvase
        0.2   11.5   4.2       0.14   12.1   0.8    2.1  2  HEPN_MAE_28990  MAE_28990/MAE_18760-like HEPN


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   0.0   5.6e-12   1.1e-08       1      43 [.      32      75 ..      32      79 .. 0.93

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 5.6e-12
      RWP-RK  1 nltleelqqyFslplkeAAksLgvskttLKricRelgI.sRWPy 43
                +lt+e++++yF  +  +AAk+Lgvs +tLKr    lg  +RWPy
  EFC36981.1 32 TLTYETIREYFVYTQSQAAKKLGVSVSTLKRKFYSLGYeNRWPY 75
                689**********************************845***9 PP

>> HTH_8  Bacterial regulatory protein, Fis family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   7.6e-06     0.015      20      38 ..      45      63 ..      40      64 .. 0.91

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 7.6e-06
                -HHHHHHHHTS-HHHHHHH CS
       HTH_8 20 nkskAArlLGisRrtLyrK 38
                 +s+AA+ LG+s +tL rK
  EFC36981.1 45 TQSQAAKKLGVSVSTLKRK 63
                69**************999 PP

>> HTH_psq  helix-turn-helix, Psq domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.2   1.6e-05     0.032      18      42 ..      45      70 ..      44      72 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.6e-05
     HTH_psq 18 SirkAArkYgiPrsTLw.rrkrgkys 42
                ++++AA+k g++ sTL  ++++ +y+
  EFC36981.1 45 TQSQAAKKLGVSVSTLKrKFYSLGYE 70
                59***************9*9998886 PP

>> HTH_23  Homeodomain-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   2.1e-05     0.041      17      36 ..      43      62 ..      35      62 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.1e-05
      HTH_23 17 GlsvreIAreLgvsrrTvyr 36
                 ++++++A++Lgvs +T+ r
  EFC36981.1 43 VYTQSQAAKKLGVSVSTLKR 62
                69***************987 PP

>> HTH_3  Helix-turn-helix
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   3.7e-05     0.073      10      28 ..      44      62 ..      38      62 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.7e-05
                HHHHHHHHHHTSSHHHHHH CS
       HTH_3 10 lsqeeLAeklGvsrstisr 28
                ++q ++A+klGvs+st+ r
  EFC36981.1 44 YTQSQAAKKLGVSVSTLKR 62
                79**************965 PP

>> TRM13  Methyltransferase TRM13
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.6   4.4e-05     0.087     178     259 ..      78     157 ..      37     160 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.4e-05
       TRM13 178 krkseaeeedekeekekeekkeeeeseeekksklsseereeiGlkakrlidegRllalkekgfeaelvkYvekevslEnvlL 259
                 + +   +++  ++++++ee++++ e+ee+  ++ +   re + + a++++ ++  +   +++++ ++v+Y +++ s E v++
  EFC36981.1  78 TVTP--KKKGMNKRTHEEEEEVSAEEEEDSYESEEEVIREPVTRSARKIVSASTPTLTSQHSKKRKVVEYQQEAASEEQVVI 157
                 4433..23333445555555566666666677777888*****************************************998 PP

>> HTH_17  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00011      0.22       1      20 [.      43      62 ..      43      65 .. 0.93

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00011
      HTH_17  1 lltveEaAelLgvsrstvyr 20
                ++t ++aA+ Lgvs+st+ r
  EFC36981.1 43 VYTQSQAAKKLGVSVSTLKR 62
                6999*************987 PP

>> HTH_7  Helix-turn-helix domain of resolvase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.2   0.00021      0.42      23      42 ..      45      64 ..      43      66 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00021
                -STTTSSSS---SSSS--SS CS
       HTH_7 23 siskIAkevnisRsTvYRyl 42
                + s+ Ak +++s+sT++R++
  EFC36981.1 45 TQSQAAKKLGVSVSTLKRKF 64
                56899*************97 PP

>> HEPN_MAE_28990  MAE_28990/MAE_18760-like HEPN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.39   7.8e+02      66     126 ..      52     117 ..      34     163 .. 0.63
   2 ?   12.1   0.8     7e-05      0.14      59     171 ..     229     339 ..     227     340 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.39
  HEPN_MAE_28990  66 slgisysdlsenfkal........ikanalktlkkkkkpdrllkefskvkelsedltaeskdklllfss 126
                     +lg+s s l+ +f  l        i+++  k+  k   ++r+ +e + v +  e+++ es+++++ ++ 
      EFC36981.1  52 KLGVSVSTLKRKFYSLgyenrwpyIRTVTPKK--K-GMNKRTHEEEEEVSAEEEEDSYESEEEVIREPV 117
                     55555555555544445555554444444433..3.557777777888888888888888888874443 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 7e-05
  HEPN_MAE_28990  59 syidyinslgisysdlsenfkalikanalktlkkkkkpdrllkefskvkelsedltaeskdklllfssnldskviik.giskvlkklglsaslnl 152
                     s id +n+++is+sd+s+n      ++++ ++ + + + rl +e+s+  + s d+ +e    ++lf+ ++++k +    i+  +   +  +s+n 
      EFC36981.1 229 STIDHLNTSNISFSDMSNNYSHPTSSSIIGNNTT-THHHRLYNEQSQTSNQSQDFGDEIAAASMLFQFASSDKKFSSpRILPPI---SSLHSTNF 319
                     789****************444455555555555.********************************99999999996777777...777***** PP

  HEPN_MAE_28990 153 ekeikgdleta.deLvkrRN 171
                     ++++ + l++   +L ++RN
      EFC36981.1 320 MNYHAQPLKKRiPSLGDYRN 339
                     **999999988999999999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (401 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1631  (0.0909699); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 2322.33
//
Query:       EFC36982.1  [L=840]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.4e-20   73.2   6.7      2e-06   28.3   0.1    4.6  4  Sel1         Sel1 repeat
    9.2e-12   45.3   0.2      0.083   13.8   0.0    6.7  6  WD40         WD domain, G-beta repeat
      5e-06   26.7   0.0      0.028   14.7   0.0    4.3  4  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.1   3.4e-10     2e-06       1      38 []     421     456 ..     421     456 .. 0.93
   2 !   18.2   0.0     5e-07     0.003       2      38 .]     458     489 ..     457     489 .. 0.87
   3 !   21.2   0.6   5.8e-08   0.00034       2      38 .]     491     525 ..     490     525 .. 0.94
   4 !    6.0   0.0    0.0033        20      12      32 ..     535     555 ..     532     556 .. 0.92

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 3.4e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a A+y +G   ++ nG++v +D++++++w+ kAA++++
  EFC36982.1 421 AQAQYHVG--IMLKNGQDVQQDQREGFQWLLKAAKNDN 456
                 68******..777**********************986 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 5e-07
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  A++ +Gmf      l ++k++e+A++w+ k+A++G+
  EFC36982.1 458 LAQFEVGMFF-----LNTDKNYERAHKWLSKSANNGH 489
                 6999999666.....448******************8 PP

  == domain 3  score: 21.2 bits;  conditional E-value: 5.8e-08
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 eA+y+++   ++ +G  v+kD  +A+ w  kAA+q +
  EFC36982.1 491 EAQYQMA--RIFNEGIWVKKDFAQAFDWGYKAAQQHH 525
                 8******..888*********************9965 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.0033
        Sel1  12 lylnGlgvpkDpekAiewyek 32 
                 ++ +G gv+k+  +A  w+ek
  EFC36982.1 535 CFNYGVGVKKNLLQAKLWMEK 555
                 789****************98 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.036   2.1e+02      13      37 ..      44      68 ..      20      69 .. 0.73
   2 ?    3.6   0.0     0.023   1.4e+02      12      35 ..      97     120 ..      83     123 .. 0.70
   3 !   13.8   0.0   1.4e-05     0.083      13      38 .]     139     164 ..     129     164 .. 0.91
   4 ?    4.5   0.1     0.012        70      19      38 .]     193     212 ..     173     212 .. 0.82
   5 !    5.5   0.1     0.006        36      11      38 .]     248     280 ..     240     280 .. 0.83
   6 !    5.5   0.0    0.0057        34       9      34 ..     293     317 ..     284     318 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.036
                EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40 13 vtslafspdgawlasGsdDgtvriW 37
                v ++ f++d ++la +s+ g ++++
  EFC36982.1 44 VKAIEFNHDRTLLAISSYEGFIKVF 68
                77899*********9999**99996 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.023
                 SEEEEEEETTSSEEEEEETTSEEE CS
        WD40  12 svtslafspdgawlasGsdDgtvr 35 
                 ++++l+f    +++++G+d g+v+
  EFC36982.1  97 PIRCLKFINQLKYIVCGTDRGNVH 120
                 49999999999****999666665 PP

  == domain 3  score: 13.8 bits;  conditional E-value: 1.4e-05
                 EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  13 vtslafspdgawlasGsdDgtvriWd 38 
                 v++l ++p  +++++G+d+g++ +W+
  EFC36982.1 139 VRCLMVHPKYPFIMAGGDNGKILLWN 164
                 99***********************8 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.012
                 ETTSSEEEEEETTSEEEEEE CS
        WD40  19 spdgawlasGsdDgtvriWd 38 
                 + + + ++sGs + tv +W+
  EFC36982.1 193 CFNTDIVISGSLNSTVTVWN 212
                 4477889************8 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.006
                 SSEEEEEEETTSSE.....EEEEETTSEEEEEE CS
        WD40  11 ssvtslafspdgaw.....lasGsdDgtvriWd 38 
                 s+v++++f + +++     ++++ dDg+  i+d
  EFC36982.1 248 SPVNCVDFYRGNDYnrrnwFVASFDDGSTQIFD 280
                 569***9999999999999878999**988887 PP

  == domain 6  score: 5.5 bits;  conditional E-value: 0.0057
                 SS.SSE.EEEEEETTSSEEEEEETTSEE CS
        WD40   9 GH.ssv.tslafspdgawlasGsdDgtv 34 
                  H  +v t++    +g++++sGs+Dg v
  EFC36982.1 293 IHpEPVtTCI---FEGDFIFSGSEDGLV 317
                 5877795555...89999*******965 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   4.7e-06     0.028       2      87 ..      48     142 ..      47     145 .. 0.85
   2 ?    2.9   0.0     0.022   1.3e+02      39      79 ..     137     177 ..     132     193 .. 0.83
   3 !    4.8   0.0    0.0059        35      52      85 ..     266     299 ..     247     342 .. 0.89
   4 ?   -2.2   0.0      0.88   5.3e+03      51      67 ..     773     789 ..     767     796 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 4.7e-06
  ANAPC4_WD40   2 swcptmDLiAlatedgellvfRlng............qrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtcl 87 
                  +++  + L+A+ + +g + vfR+              q  +t+ + +++  +r+L++ ++ k ++ +++ g+v+++d e+   v  ++ ++   v cl
   EFC36982.1  48 EFNHDRTLLAISSYEGFIKVFRVRVtttgesnsadelQLHYTF-TIEPKAPIRCLKFINQLKYIVCGTDRGNVHVIDYENDLEVVRVPFGEY--VRCL 142
                  6788899****************99888888888887444444.569*********************************998888888766..6665 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.022
  ANAPC4_WD40  39 sevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvk 79 
                  + vr+L+ +p+  +++ + ++g++ l + e++  v+++  +
   EFC36982.1 137 EYVRCLMVHPKYPFIMAGGDNGKILLWNWEKKFAVEHVMSN 177
                  6799***************************9888887554 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.0059
  ANAPC4_WD40  52 lLavaysdgevrlldaesgkvvhslsvksekavt 85 
                   ++ +++dg+ +++d  sg+++ +ls  + + vt
   EFC36982.1 266 WFVASFDDGSTQIFDCDSGECIVKLSQIHPEPVT 299
                  5678899**************9998876666554 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 0.88
  ANAPC4_WD40  51 klLavaysdgevrllda 67 
                   +L + ++dgev + ++
   EFC36982.1 773 DFLTIQHKDGEVIISNI 789
                  57888999999888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (840 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       751  (0.0418874); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.80u 0.32s 00:00:01.12 Elapsed: 00:00:00.52
# Mc/sec: 4882.82
//
Query:       EFC36983.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.9e-20   71.5   3.7    1.1e-19   71.1   3.2    1.5  1  Laminin_G_3  Concanavalin A-like lectin/glucanases superfamil
    0.00022   21.5   5.0    0.00022   21.5   5.0    2.2  2  EGF_2        EGF-like domain


Domain annotation for each model (and alignments):
>> Laminin_G_3  Concanavalin A-like lectin/glucanases superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.1   3.2   1.2e-23   1.1e-19      11     152 .]     234     370 ..     224     370 .. 0.88

  Alignments for each domain:
  == domain 1  score: 71.1 bits;  conditional E-value: 1.2e-23
  Laminin_G_3  11 daslp.tssfTvsaWvkpdslpsaaqiiissssdgrgfelgldgsgrlrfsvnagngaeesvtsgasvpageWtHvavtydggtlrlYvNGvevgsat 107
                  +++++ t s ++s+W+k    +  a+++   ++++ ++ + +++++ ++f+ ++   +   vt g+ +++++W H+++++ ++ + lY++G + ++++
   EFC36983.1 234 TVNVNlTVSNSFSLWLKSPYGGV-AMAFS--TNGN-YIFFNVASAKGFSFYDDKF--TTPFVTDGTLFATDVWRHLVFVFRTDGTDLYIDGSLYKTSA 325
                  3444447888999****999998.56777..8888.99999***99999976655..578999**********************************9 PP

  Laminin_G_3 108 ltggllsatsgplviGrdpggddpfdGlidevriynralsaaeIa 152
                   + ++++ ++g l+iG+ + g+++++G+i++v+i+ +al+a e++
   EFC36983.1 326 TSIASKNLSDGKLTIGGHNAGTYYYTGYIANVMIFTKALTAPEVS 370
                  99999999***********************************95 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   3.5       1.2   1.1e+04       1      10 [.     106     116 ..     105     128 .. 0.60
   2 !   21.5   5.0   2.5e-08   0.00022       5      32 .]     139     165 ..     135     165 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.2
       EGF_2   1 Csas.deiCgg 10 
                 Cs+  +++C+ 
  EFC36983.1 106 CSTYnGSDCNA 116
                 66666555553 PP

  == domain 2  score: 21.5 bits;  conditional E-value: 2.5e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+ghG+C++++ +C C   y G++C
  EFC36983.1 139 ASVCSGHGSCIAPN-NCTCTKPYIGASC 165
                 679********999.8************ PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.25s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 2715.88
//
Query:       EFC36984.1  [L=198]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.6e-08   35.1   0.2    3.5e-08   34.0   0.1    1.6  2  AAA         ATPase family associated with various cellular ac
     0.0014   18.3   0.0      0.003   17.3   0.0    1.6  1  AAA_lid_3   AAA+ lid domain
     0.0079   15.5   1.1       0.34   10.1   0.2    2.2  2  KAP_NTPase  KAP family P-loop domain
  ------ inclusion threshold ------
      0.057   13.4   1.5      0.099   12.7   0.1    2.1  3  Vps4_C      Vps4 C terminal oligomerisation domain


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.0   0.1   7.7e-12   3.5e-08      47     131 ..       2      78 ..       1      79 [. 0.91
   2 ?   -1.9   0.0      0.91   4.1e+03     107     120 ..     122     135 ..      89     161 .. 0.57

  Alignments for each domain:
  == domain 1  score: 34.0 bits;  conditional E-value: 7.7e-12
                 HHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHHHSTTSSEEEETT CS
         AAA  47 relfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkkeskvivigatnrpdkldpallrgRfdrkieie 131
                 +e+f++ak ++ psi++iD+++    ++   +se+e +v++++l+ + + ++   +viv++++ +p++++pa++ + f+r+++i+
  EFC36984.1   2 QEVFEKAKLSQ-PSIIVIDDLEFCDWNS---NSEKEISVLKEFLQSMYDRES---RVIVLVISSTPWNINPAVR-KIFKRRFHIP 78 
                 789***99987.*********9886666...899999999999999999999...7******************.9****99998 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.91
                 EEESSGGGSTHHHH CS
         AAA 107 gatnrpdkldpall 120
                 +   +++ + +al+
  EFC36984.1 122 VRDSQMNIIRNALM 135
                 33333333333333 PP

>> AAA_lid_3  AAA+ lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   6.7e-07     0.003       3      33 ..     102     132 ..     100     150 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 6.7e-07
   AAA_lid_3   3 dlkeLAerTeGySGADlaalcreAallAlrr 33 
                  ++e+  +++GyS ADl  ++r + ++ +r 
  EFC36984.1 102 EIEEISTMCDGYSYADLMCVVRDSQMNIIRN 132
                 589********************99987665 PP

>> KAP_NTPase  KAP family P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.0    0.0044        20     168     187 ..       5      26 ..       1      60 [. 0.77
   2 !   10.1   0.2   7.6e-05      0.34     239     312 ..      68     148 ..      67     168 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0044
  KAP_NTPase 168 Lda..lqkrlVvviDdLDrcet 187
                 +++  l+++ ++viDdL+ c+ 
  EFC36984.1   5 FEKakLSQPSIIVIDDLEFCDW 26 
                 5555678899********9984 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 7.6e-05
  KAP_NTPase 239 ekiiqlpvyLppsglrevkkvlmeaveaseettesesrdetlgnsas.......ksnlqlaldlskilltedfsdvnpRem 312
                 +ki++ ++ +p  ++++  + l+ a+++s  ++ + +++ t+    s          +q+++  + +++t +++++++ ++
  EFC36984.1  68 RKIFKRRFHIPLPDKEKRIEILRDAFRNSSIQDDEIEEISTMCDGYSyadlmcvVRDSQMNIIRNALMATNNSFNISLNAL 148
                 8**************************************9999999999****9888999999999999999888887655 PP

>> Vps4_C  Vps4 C terminal oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       2.3     1e+04      20      32 ..       6      19 ..       3      22 .. 0.62
   2 ?   -2.2   0.0      0.95   4.2e+03      46      59 ..      30      43 ..      27      44 .. 0.80
   3 ?   12.7   0.1   2.2e-05     0.099      30      60 ..     152     182 ..     143     182 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.3
      Vps4_C 20 psdklleP.pvtlk 32
                ++ kl +P  + ++
  EFC36984.1  6 EKAKLSQPsIIVID 19
                56788888444444 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.95
      Vps4_C 46 skeDLekheeFTke 59
                s++++  ++eF ++
  EFC36984.1 30 SEKEISVLKEFLQS 43
                78999999999875 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 2.2e-05
      Vps4_C  30 tlkDflkalkkarptVskeDLekheeFTkef 60 
                 t +D++k+l++ +++V+ ++ +kh +F ++f
  EFC36984.1 152 TKSDVIKSLQTIKSSVTIQEEAKHLQFQQDF 182
                 689*************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (198 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       966  (0.0538792); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1204.41
//
Query:       EFC36985.1  [L=710]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00047   20.5   5.0    0.00047   20.5   5.0    2.4  2  EGF_2        EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   4.1         1   1.8e+04       1      15 [.     106     118 ..     106     128 .. 0.61
   2 !   20.5   5.0   2.6e-08   0.00047       5      32 .]     139     165 ..     135     165 .. 0.90

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 1
       EGF_2   1 Csas.deiCgghGtCv 15 
                 Cs+  +++C+   tC 
  EFC36985.1 106 CSTYnGSDCN---TCQ 118
                 7777766666...443 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 2.6e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+ghG+C++++ +C C   y G++C
  EFC36985.1 139 ASVCSGHGSCIAPN-NCTCTKPYIGASC 165
                 679********999.8************ PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (710 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1057  (0.0589548); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 4214.42
//
Query:       EFC36986.1  [L=198]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-08   35.1   0.3    3.5e-08   34.0   0.1    1.7  2  AAA         ATPase family associated with various cellular ac
    0.00085   19.1   0.0     0.0018   18.1   0.0    1.6  1  AAA_lid_3   AAA+ lid domain
  ------ inclusion threshold ------
      0.012   14.8   1.2       0.52    9.5   0.3    2.2  2  KAP_NTPase  KAP family P-loop domain
      0.057   13.4   1.5      0.099   12.7   0.1    2.1  3  Vps4_C      Vps4 C terminal oligomerisation domain


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.0   0.1   7.7e-12   3.5e-08      47     131 ..       2      78 ..       1      79 [. 0.91
   2 ?   -1.5   0.0      0.72   3.2e+03     107     107 ..     122     122 ..      85     162 .. 0.57

  Alignments for each domain:
  == domain 1  score: 34.0 bits;  conditional E-value: 7.7e-12
                 HHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHHHSTTSSEEEETT CS
         AAA  47 relfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkkeskvivigatnrpdkldpallrgRfdrkieie 131
                 +e+f++ak ++ psi++iD+++    ++   +se+e +v++++l+ + + ++   +viv++++ +p++++pa++ + f+r+++i+
  EFC36986.1   2 QEVFEKAKLSQ-PSIIVIDDLEFCDWNS---NSEKEISVLKEFLQSMYDRES---RVIVLVISSTPWNINPAVR-KIFKRRFHIP 78 
                 789***99987.*********9886666...899999999999999999999...7******************.9****99998 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.72
                 E CS
         AAA 107 g 107
                 +
  EFC36986.1 122 V 122
                 2 PP

>> AAA_lid_3  AAA+ lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0     4e-07    0.0018       3      33 ..     102     132 ..     100     150 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 4e-07
   AAA_lid_3   3 dlkeLAerTeGySGADlaalcreAallAlrr 33 
                  ++e+  +++GyS ADl  ++r + ++ +r 
  EFC36986.1 102 EIEEISTKCDGYSYADLMCVVRDSQMNIIRN 132
                 589********************99987665 PP

>> KAP_NTPase  KAP family P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0    0.0044        20     168     187 ..       5      26 ..       1      60 [. 0.77
   2 ?    9.5   0.3   0.00011      0.52     239     312 ..      68     148 ..      67     168 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0044
  KAP_NTPase 168 Lda..lqkrlVvviDdLDrcet 187
                 +++  l+++ ++viDdL+ c+ 
  EFC36986.1   5 FEKakLSQPSIIVIDDLEFCDW 26 
                 5555678899********9984 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00011
  KAP_NTPase 239 ekiiqlpvyLppsglrevkkvlmeaveaseettesesrdetlgnsas.......ksnlqlaldlskilltedfsdvnpRem 312
                 +ki++ ++ +p  ++++  + l+ a+++s  ++ + +++ t     s          +q+++  + +++t +++++++ ++
  EFC36986.1  68 RKIFKRRFHIPLPDKEKRIEILRDAFRNSSIQDDEIEEISTKCDGYSyadlmcvVRDSQMNIIRNALMATNNSFNISLNAL 148
                 8*************************************9998888889999999888999999999999999888887655 PP

>> Vps4_C  Vps4 C terminal oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       2.3     1e+04      20      32 ..       6      19 ..       3      22 .. 0.62
   2 ?   -2.2   0.0      0.95   4.2e+03      46      59 ..      30      43 ..      27      44 .. 0.80
   3 ?   12.7   0.1   2.2e-05     0.099      30      60 ..     152     182 ..     143     182 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.3
      Vps4_C 20 psdklleP.pvtlk 32
                ++ kl +P  + ++
  EFC36986.1  6 EKAKLSQPsIIVID 19
                56788888444444 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.95
      Vps4_C 46 skeDLekheeFTke 59
                s++++  ++eF ++
  EFC36986.1 30 SEKEISVLKEFLQS 43
                78999999999875 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 2.2e-05
      Vps4_C  30 tlkDflkalkkarptVskeDLekheeFTkef 60 
                 t +D++k+l++ +++V+ ++ +kh +F ++f
  EFC36986.1 152 TKSDVIKSLQTIKSSVTIQEEAKHLQFQQDF 182
                 689*************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (198 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       963  (0.0537119); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 1177.26
//
Query:       EFC36987.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1339  (0.0746835); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 2896.39
//
Query:       EFC36988.1  [L=773]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
          5    6.9   5.7        5.6    6.7   3.6    2.1  2  DUF637    Possible hemagglutinin (DUF637)


Domain annotation for each model (and alignments):
>> DUF637  Possible hemagglutinin (DUF637)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   3.6   0.00031       5.6      49     117 ..      38     107 ..      35     137 .. 0.87
   2 ?   -2.6   0.1      0.23   4.1e+03      97     110 ..     132     146 ..     130     158 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00031
      DUF637  49 llsgiddaslatsqdvaknavpqadastvsgvaqrlaaqlaqsvisagvntai.nGGsfkdNlktallss 117
                 +  ++++++lat+ ++++ +++q d+ t+  ++q l  q  +   +  +++ i n +s ++Nl+++++++
  EFC36988.1  38 VPDELFQQILATVANQNNMTTTQPDQVTLFTLQQSLIHQQTEQAEQYFISSSInNNTSTSTNLEESVRGN 107
                 5567788999****************************9999999********99***********9987 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.23
      DUF637  97 vntai.nGGsfkdNl 110
                 vnt i n ++++dN+
  EFC36988.1 132 VNTNInNNTNLNDNV 146
                 899998999999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (773 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1579  (0.0880696); expected 358.6 (0.02)
Passed bias filter:                      259  (0.0144459); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.79u 0.33s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 4396.99
//
Query:       EFC36989.1  [L=502]
Description: hypothetical protein NAEGRDRAFT_82048 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00069   19.4   6.6      0.024   14.3   0.3    3.2  3  Cupin_8   Cupin-like domain
     0.0036   17.7   0.1      0.012   15.9   0.0    1.9  2  DUF4019   Protein of unknown function (DUF4019)


Domain annotation for each model (and alignments):
>> Cupin_8  Cupin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   1.4     0.013   1.2e+02      36     115 ..      53     138 ..      15     211 .. 0.65
   2 !   14.3   0.3   2.7e-06     0.024       3      35 ..     315     346 ..     313     411 .. 0.78
   3 !    4.0   0.0    0.0039        35     210     229 ..     466     485 ..     418     500 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.013
     Cupin_8  36 lleylkekaedvkvsvektpdgeadsfkeneelkfvkpeeeemtfkdfldelearrdtrsepyaylqnanlasefpelk........e 115
                 l++ l +  +   + + ++  +++ s   +++ +f+  +++ +t +  ++++ +++dt+s++  ++ n+n+ +e + ++        e
  EFC36989.1  53 LDASLLSPTSANATVRTRR--NNNTSTTSGKSSVFQLVKSKATTSSLATSNIASNNDTTSHTNSTTSNSNVFDENNGFEvvdnhrdlE 138
                 4444444433333332222..3444455556666666677777777778888888888888888888888888777776444443330 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 2.7e-06
     Cupin_8   3 effreyvakskPviikgalkdwpalqkwtddey 35 
                 e f++y+++skP+++k + ++w   ++w++ e+
  EFC36989.1 315 ENFENYLSQSKPIVLKKYSNKWISSSTWKK-EF 346
                 6689************************96.33 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.0039
     Cupin_8 210 kalevtlnaGevLylPalWf 229
                 +  e++++  +++y+P++W 
  EFC36989.1 466 EDTETEIKTNDCIYIPSGWS 485
                 456899999**********6 PP

>> DUF4019  Protein of unknown function (DUF4019)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       1.8   1.6e+04      39      58 ..     187     206 ..     181     211 .. 0.70
   2 !   15.9   0.0   1.4e-06     0.012      12      70 ..     330     387 ..     328     397 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 1.8
     DUF4019  39 kavraplGavksRklasaee 58 
                 k ++++lG++ +R +++ + 
  EFC36989.1 187 KFANSKLGRLIRRFINHIRV 206
                 55678899998887777665 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 1.4e-06
     DUF4019  12 gkyeesWeeasalfkkavteeewekalkavraplGavksRklasaeearslpgaPdGeY 70 
                 +ky++ W ++s+  k+ ++++e++++l++++++l +  +Rk +s + ++ + ++P+  Y
  EFC36989.1 330 KKYSNKWISSSTWKKEFTSNKEFIRKLNKMKKQLSKYIKRKGVSITLVN-MDKLPSSVY 387
                 5899**************************************9999776.677776666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2102  (0.11724); expected 358.6 (0.02)
Passed bias filter:                      714  (0.0398237); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.34s 00:00:01.10 Elapsed: 00:00:00.54
# Mc/sec: 2823.05
//
Query:       EFC36990.1  [L=428]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      1e-42  145.7   0.4    2.9e-42  144.2   0.0    1.9  2  AAA              ATPase family associated with various cellul
    4.4e-20   71.4   0.6    8.3e-20   70.5   0.6    1.5  1  Prot_ATP_ID_OB   Proteasomal ATPase OB C-terminal domain
    8.6e-11   41.5   0.6      2e-10   40.3   0.1    1.9  1  AAA_lid_3        AAA+ lid domain
    2.5e-06   28.0   0.7    0.00059   20.3   0.1    2.6  3  AAA_16           AAA ATPase domain
    7.4e-06   26.0   0.9    3.1e-05   24.0   0.1    2.5  2  AAA_5            AAA domain (dynein-related subfamily)
    5.2e-05   23.0   0.0    0.00018   21.3   0.0    1.9  1  RuvB_N           Holliday junction DNA helicase RuvB P-loop d
      7e-05   23.0   0.4    0.00066   19.8   0.0    2.6  2  AAA_2            AAA domain (Cdc48 subfamily)
    0.00013   22.2   0.4      0.021   15.1   0.1    2.6  2  AAA_22           AAA domain
     0.0019   17.6   0.0     0.0062   15.9   0.0    1.8  1  Mg_chelatase     Magnesium chelatase, subunit ChlI
     0.0043   16.5   0.1      0.036   13.5   0.0    2.3  2  PhoH             PhoH-like protein
  ------ inclusion threshold ------
      0.011   15.9   0.0      0.025   14.7   0.0    1.7  1  AAA_33           AAA domain
      0.013   14.7   0.0      0.027   13.6   0.0    1.6  1  DUF815           Protein of unknown function (DUF815)
      0.018   14.8   0.1      0.038   13.7   0.1    1.5  1  IstB_IS21        IstB-like ATP binding protein
      0.022   14.1   0.7      0.078   12.3   0.0    2.1  2  ATPase           KaiC
      0.029   13.9   0.0      0.088   12.3   0.0    1.8  1  AAA_7            P-loop containing dynein motor region
      0.036   13.8   0.0        0.2   11.3   0.0    2.1  2  Sigma54_activat  Sigma-54 interaction domain
      0.042   13.6   3.6      0.096   12.4   0.1    2.4  2  AAA_24           AAA domain
      0.065   12.8   1.5       0.33   10.5   0.2    2.4  2  AAA_25           AAA domain
      0.068   13.7   0.2       0.29   11.7   0.0    2.2  2  AAA_18           AAA domain
      0.089   12.5   0.0       0.21   11.3   0.0    1.7  1  AAA_30           AAA domain
       0.11   12.5   0.0       0.26   11.3   0.0    1.6  1  TsaE             Threonylcarbamoyl adenosine biosynthesis pro
       0.14   12.6   0.0       0.37   11.2   0.0    1.8  1  RNA_helicase     RNA helicase
       0.15   11.8   0.0       0.58    9.8   0.0    2.0  1  Prot_ATP_OB_N    Proteasomal ATPase OB N-terminal domain
       0.17   11.6   2.3       0.65    9.7   0.0    2.3  2  AAA_11           AAA domain
       0.23   11.3   4.9        8.5    6.2   0.0    3.1  3  ATPase_2         ATPase domain predominantly from Archaea
        2.4    8.7   5.6        4.4    7.8   0.0    2.9  2  ABC_tran         ABC transporter


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       4.7   3.2e+03      47      94 ..      62     117 ..      36     140 .. 0.60
   2 !  144.2   0.0   4.2e-45   2.9e-42       1     132 []     212     345 ..     212     345 .. 0.96

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 4.7
                 HHHHHHHHHTS.......TS.EEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHH CS
         AAA  47 relfkeakeka.......kp.silfiDEidalaksrsgseseeeervvnqLlteld 94 
                 +e ++++k ++       +   il  DE ++++++ s+ + +ee++  ++ ++   
  EFC36990.1  62 KENVEKIKLNKqlpylvaTVvEILETDENEEIIQDGSSVDLDEERKGKSAVIKTST 117
                 44444444333444544422355566666666666666666666666555555544 PP

  == domain 2  score: 144.2 bits;  conditional E-value: 4.2e-45
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH...TTCCCHHHHHHHHHHHHHHHHT CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksr...sgseseeeervvnqLlteldgv 96 
                 vllyGppGtGKTlla+a a +++++fl++ g++l+++++g+++k +r+ f+ a+eka p i+fiDE+da++++r   ++s ++e +r++ +Ll+++dg+
  EFC36990.1 212 VLLYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAREKA-PAIIFIDELDAIGTKRfgsDKSGDREVQRTMLELLNQMDGF 309
                 79******************************************************9.****************997777899999************* PP

                 TTSSSTEEEEEEESSGGGSTHHHHS.TTSSEEEETTS CS
         AAA  97 kkkeskvivigatnrpdkldpallr.gRfdrkieiel 132
                 +++  +v vi+atnr+d ldpallr gR+drkie++l
  EFC36990.1 310 SQD-TRVKVIAATNRIDILDPALLRsGRIDRKIEFPL 345
                 **7.66****************************985 PP

>> Prot_ATP_ID_OB  Proteasomal ATPase OB C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.5   0.6   1.2e-22   8.3e-20       1      57 []      78     154 ..      78     154 .. 1.00

  Alignments for each domain:
  == domain 1  score: 70.5 bits;  conditional E-value: 1.2e-22
                     EEEEEEE-TT....................SSEEEEE-TTS-EEEEEE-GGGSSST--TTEEEEEETTTTEEEEEE- CS
  Prot_ATP_ID_OB   1 VatVsEvldd....................teraiVktssdeevvvslagavpremLrpgDlVavdkdtgfifEkLP 57 
                     VatV+E+l+                     +++a++kts+++++++++ g+v+ e+L+pg lV+v+kd+++++EkLP
      EFC36990.1  78 VATVVEILETdeneeiiqdgssvdldeerkGKSAVIKTSTRQTIYLPVIGLVDSEDLKPGELVGVNKDSFLVLEKLP 154
                     9***************************************************************************9 PP

>> AAA_lid_3  AAA+ lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.3   0.1   2.9e-13     2e-10       1      45 []     367     411 ..     367     411 .. 0.98

  Alignments for each domain:
  == domain 1  score: 40.3 bits;  conditional E-value: 2.9e-13
   AAA_lid_3   1 dvdlkeLAerTeGySGADlaalcreAallAlrrgikeitmedfee 45 
                 dv+++e+ + +e + GA ++a+c eA++ Alrr+ +++  edf+e
  EFC36990.1 367 DVNWEEISRCCEDFNGAQMKAVCVEAGMIALRRDATQVMHEDFME 411
                 9******************************************86 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       9.8   6.8e+03      80      96 ..      88     104 ..      54     132 .. 0.57
   2 !   20.3   0.1   8.5e-07   0.00059      24      50 ..     209     235 ..     198     250 .. 0.79
   3 ?    5.5   0.0     0.029        20     121     146 ..     255     287 ..     241     318 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 9.8
      AAA_16  80 ellrqlldeaesaelea 96 
                 +  +++ ++ +s +l++
  EFC36990.1  88 DENEEIIQDGSSVDLDE 104
                 33333433333333333 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 8.5e-07
      AAA_16  24 pelvllsGesGvGKsslvrellralek 50 
                 p  vll+G++G+GK+ l+r+++ + ++
  EFC36990.1 209 PKGVLLYGPPGTGKTLLARACAAQTKA 235
                 589******************965443 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.029
      AAA_16 121 ellkrllallsrderplvlvlDdlq........w 146
                  l+++++al+++ + p ++++D+l+         
  EFC36990.1 255 KLVRDAFALARE-KAPAIIFIDELDaigtkrfgS 287
                 566777889998.778*********555554441 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       3.9   2.7e+03      78     107 ..      33      54 ..       4      96 .. 0.53
   2 !   24.0   0.1   4.6e-08   3.1e-05       1     135 [.     211     332 ..     211     334 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3.9
                 -HHHHHHHHHHHHSSEEE..-SSSEEE--- CS
       AAA_5  78 esevlnsLlslleerrllleeggelvkakn 107
                 ++ + n+ +   +e        +++++ ++
  EFC36990.1  33 SRLIDNEIHVFRNE--------KKRIQYEE 54 
                 33333333222222........22222222 PP

  == domain 2  score: 24.0 bits;  conditional E-value: 4.6e-08
                 EEEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--.........--------G-SEEEEESGGG--HHHHHHHHHHHHSSEEE..-S CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraaregeilvlDEveraesevlnsLlslleerrllleeg 99 
                 +vlL GppGtgK+ la+  aa ++++++  ++++      l++     +g +  +d  +    + ++i+++DE++ + ++ ++s  s   e ++ + e+
  EFC36990.1 211 GVLLYGPPGTGKTLLARACAAQTKATFLKLAGPQ------LVQMFI-GDGAKLVRDAFALAREKAPAIIFIDELDAIGTKRFGSDKSGDREVQRTMLEL 302
                 59*************************9999998......666665.5777777777777777799**********99999999888766666665565 PP

                 SSEEE---......-EEEEEESS--.-TT-TTHHHH CS
       AAA_5 100 gelvkaknddllerfrviatanpldrslnelspalr 135
                  ++++  ++    r+ via++n+ d     l+pal+
  EFC36990.1 303 LNQMDGFSQ--DTRVKVIAATNRID----ILDPALL 332
                 555544442..34699999999998....6666665 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.0   2.6e-07   0.00018      35      94 ..     211     278 ..     195     284 .. 0.76

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 2.6e-07
      RuvB_N  35 hvllyGpPGlGkttlakiiakelgvklkitsgPvleka..gdlaalltn...l...eekdvlfideih 94 
                  vllyGpPG Gkt la+  a++ ++++   +gP l +   gd a l+ +   l   ++  ++fide+ 
  EFC36990.1 211 GVLLYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMfiGDGAKLVRDafaLareKAPAIIFIDELD 278
                 69*******************************99774336655554321112111455788888876 PP

>> AAA_2  AAA domain (Cdc48 subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.2       4.2   2.9e+03      21      53 ..      63      94 ..      41     109 .. 0.55
   2 !   19.8   0.0   9.6e-07   0.00066       6     104 ..     212     304 ..     208     317 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 4.2
                HHHHHHTT-....-EEEEEGGG-------THHH CS
       AAA_2 21 kalaellfvkkekkliradaselleeeevehlv 53
                ++++++   +k+ +  +a   e+le +e e+++
  EFC36990.1 63 ENVEKIKL-NKQLPYLVATVVEILETDENEEII 94
                22222222.444444555555555555544444 PP

  == domain 2  score: 19.8 bits;  conditional E-value: 9.6e-07
                 EEEE--TTSSHHHHHHHHHHHTT-....-EEEEEGGG-------THHHHHHHHHTTT-HHHHTTS..EEEEETGGG-------------H.HHHHHHHH CS
       AAA_2   6 illlgptgvGktelakalaellfvkkekkliradaselleeeevehlvsrligappgyvgaeegG..ivllDEidKihpkessgadvSre.gVqrdLLq 101
                 +ll gp g+Gkt+la+a a   ++    ++  +   +l +      + +  +  +++   a e+   i+++DE+d i   ++ g+d S++ +Vqr +L 
  EFC36990.1 212 VLLYGPPGTGKTLLARACAAQTKA----TFLKLAGPQLVQ----MFIGDGAKLVRDAFALAREKApaIIFIDELDAIGT-KRFGSDKSGDrEVQRTMLE 301
                 67899*************999985....888887777777....55555555555555555555566************.777888876449******* PP

                 HHH CS
       AAA_2 102 ile 104
                 +l 
  EFC36990.1 302 LLN 304
                 996 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.1   3.1e-05     0.021       8      29 ..     212     233 ..     207     250 .. 0.83
   2 ?    4.6   0.0     0.053        36      86     126 ..     264     318 ..     250     327 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 3.1e-05
      AAA_22   8 lvvtGesGtGKTtllrrlleql 29 
                 ++++G++GtGKT+l+r  + q 
  EFC36990.1 212 VLLYGPPGTGKTLLARACAAQT 233
                 689*************999987 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.053
      AAA_22  86 lraravielliiDEaqhlr.....s.........eealeeLrsllnl.srkgvqli 126
                 +r++a ++++ iDE + +      s          ++le L ++  + +++ v++i
  EFC36990.1 264 AREKA-PAIIFIDELDAIGtkrfgSdksgdrevqRTMLELLNQMDGFsQDTRVKVI 318
                 33444.59**********87766516677877778888888666554555555554 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   9.1e-06    0.0062       9      42 ..     196     229 ..     190     235 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 9.1e-06
  Mg_chelatase   9 eeakraleiaaaGgHnlllvGppGsGKtmlakrl 42 
                   ++a r  +i ++    +ll+GppG+GKt+la++ 
    EFC36990.1 196 NQADRFTKIGISPPKGVLLYGPPGTGKTLLARAC 229
                   5777888888888999***************975 PP

>> PhoH  PhoH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.0   5.3e-05     0.036      21      43 ..     211     233 ..     192     239 .. 0.81
   2 ?    0.0   0.0       0.7   4.8e+02      74     114 ..     293     333 ..     262     341 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.3e-05
                 EEEEE--TTSSTTHHHHHHHHHH CS
        PhoH  21 ivfaiGpaGtGKtylavalavea 43 
                  v   Gp GtGKt+la a+a++ 
  EFC36990.1 211 GVLLYGPPGTGKTLLARACAAQT 233
                 57889***************985 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.7
                 ----TTTHHHHHHHTTTS-TTCHHHHHHTTSEEEEEGGGGT CS
        PhoH  74 ekvdpylrplydaLkdllgaekvekllekgkievaplaymR 114
                   v+  +  l ++++ + ++ +v+ +  +++i +++ a +R
  EFC36990.1 293 REVQRTMLELLNQMDGFSQDTRVKVIAATNRIDILDPALLR 333
                 456677778889999999999999999********999999 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.0   3.7e-05     0.025       2      28 ..     212     238 ..     212     324 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 3.7e-05
      AAA_33   2 vllvGlpGsGKstlaerllkklgavll 28 
                 vll G+pG+GK+ la+  +++++a++l
  EFC36990.1 212 VLLYGPPGTGKTLLARACAAQTKATFL 238
                 7899***************99996665 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   3.9e-05     0.027      52     116 ..     208     277 ..     171     328 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3.9e-05
      DUF815  52 pannvLLwGarGtGKSslvkallneyaeegLrli..evekedlkelpklve...llrerperfilfvDDL 116
                 p + vLL+G  GtGK  l +a+ ++++++ L+l   ++ +  + +  klv+   +l++++   i+f+D L
  EFC36990.1 208 PPKGVLLYGPPGTGKTLLARACAAQTKATFLKLAgpQLVQMFIGDGAKLVRdafALAREKAPAIIFIDEL 277
                 6678*************************98875334445555555555542226778888889999987 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   5.4e-05     0.038      48      71 ..     210     233 ..     202     250 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 5.4e-05
   IstB_IS21  48 enivllGpsGvGKshlaialgvea 71 
                 ++++l Gp+G+GK+ la a + ++
  EFC36990.1 210 KGVLLYGPPGTGKTLLARACAAQT 233
                 6799*************9988764 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.3       1.6   1.1e+03      91     120 ..      41      70 ..      16      95 .. 0.68
   2 ?   12.3   0.0   0.00011     0.078       9      37 ..     199     227 ..     195     235 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.6
      ATPase  91 saeesaeekdkedleelieelaeaikeika 120
                 +  ++++++ +++ + ++e+++e +++ik 
  EFC36990.1  41 HVFRNEKKRIQYEENTMKEKIKENVEKIKL 70 
                 333444456666666777777777777765 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 0.00011
      ATPase   9 DeilkgGipegrvvlitGepGtGKtifal 37 
                 D+++k Gi   + vl++G pGtGKt++a 
  EFC36990.1 199 DRFTKIGISPPKGVLLYGPPGTGKTLLAR 227
                 788889999999***************96 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   0.00013     0.088      27      58 ..     203     234 ..     185     290 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00013
       AAA_7  27 elllknkkpvllvGptGtGKtviikdllkkld 58 
                 +  ++  k vll+Gp GtGKt++++ +  + +
  EFC36990.1 203 KIGISPPKGVLLYGPPGTGKTLLARACAAQTK 234
                 555666789**************999777666 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00029       0.2      21      47 ..     208     234 ..     188     246 .. 0.79
   2 ?   -1.3   0.0       2.3   1.6e+03     131     143 ..     311     323 ..     292     327 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00029
                      SSS-EEEECSTTSSHHHHHHHHHHHST CS
  Sigma54_activat  21 tdlsvlitGesGtGKellaraiheask 47 
                       +  vl+ G  GtGK+llara+ +++k
       EFC36990.1 208 PPKGVLLYGPPGTGKTLLARACAAQTK 234
                      4478****************9877655 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 2.3
                      EE--EEEEEEESS CS
  Sigma54_activat 131 ikvdvriiaatne 143
                      +++ v++iaatn+
       EFC36990.1 311 QDTRVKVIAATNR 323
                      5678999999996 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.8      0.35   2.4e+02     117     186 ..      31     116 ..      21     122 .. 0.67
   2 ?   12.4   0.1   0.00014     0.096       5      22 ..     212     229 ..     209     280 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.35
      AAA_24 117 klqelrknvifiahektrkdedpegeakytrlepklgk.ktanelkeevDlvlranlkred................kvgervlkts 186
                 + + l +n i + + ++++++ +e + ++ +++ +++k k  ++l++ v +v+++  + e                 k+   v+kts
  EFC36990.1  31 HRSRLIDNEIHVFRNEKKRIQYEENT-MKEKIKENVEKiKLNKQLPYLVATVVEILETDENeeiiqdgssvdldeerKGKSAVIKTS 116
                 55667777788888888888888666.677777776663558899999999998655433356666666666666655555555555 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 0.00014
      AAA_24   5 iliyGpsgiGKTtlakel 22 
                 +l+yGp+g+GKT la+  
  EFC36990.1 212 VLLYGPPGTGKTLLARAC 229
                 89************9876 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.2   0.00048      0.33      36      56 ..     212     232 ..     205     247 .. 0.85
   2 ?    0.8   0.2      0.44   3.1e+02     131     184 ..     258     318 ..     226     321 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00048
      AAA_25  36 allaGapgtGKttlaldlala 56 
                 +ll+G+pgtGKt la   a+ 
  EFC36990.1 212 VLLYGPPGTGKTLLARACAAQ 232
                 69************9877765 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.44
      AAA_25 131 daleaaieevegvrlvviDplsralgg....densnsd....vgalvealeriarrtgaavl 184
                 ++  a ++e + ++ + iD l+++       d+  +++    + +l+++++ +++ t++ v+
  EFC36990.1 258 RDAFALARE-KAPAIIFIDELDAIGTKrfgsDKSGDREvqrtMLELLNQMDGFSQDTRVKVI 318
                 333455666.6699999999999654444446666666333234556666666666666665 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.2       3.4   2.3e+03      58      89 ..      59      88 ..      26     118 .. 0.52
   2 ?   11.7   0.0   0.00042      0.29       1      39 [.     212     256 ..     212     322 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 3.4
      AAA_18 58 dklldaleenssaleegknlvidghlaelese 89
                +k+ +++e++  +l ++ ++++  +++ le +
  EFC36990.1 59 EKIKENVEKI--KLNKQLPYLVATVVEILETD 88
                2222222222..23344444444444444433 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00042
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf......gvnlrdvakenglll 39 
                 +ll G+pG+GKt la++ +  ++       g +l +++  +g  l
  EFC36990.1 212 VLLYGPPGTGKTLLARACAAQTKAtflklaGPQLVQMFIGDGAKL 256
                 799*************98777633356666555555555555444 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0    0.0003      0.21       5      44 ..     196     235 ..     193     284 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.0003
      AAA_30   5 eQaaavealltsgdrvavltGpAGtGKttalkalreawea 44 
                 +Qa+ ++++  s+ + ++l Gp+GtGKt + +a ++  +a
  EFC36990.1 196 NQADRFTKIGISPPKGVLLYGPPGTGKTLLARACAAQTKA 235
                 688888888888888999***********99998776655 PP

>> TsaE  Threonylcarbamoyl adenosine biosynthesis protein TsaE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00038      0.26      21      46 ..     204     236 ..     177     268 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00038
                 E.......EEEEESTTSSHHHHHHHHHHHTT-- CS
        TsaE  21 v.......ilLeGdLGaGKTtlvrglakalgve 46 
                 +       +lL+G+ G+GKT l+r+ a++ + +
  EFC36990.1 204 IgisppkgVLLYGPPGTGKTLLARACAAQTKAT 236
                 133344449*****************9988765 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00054      0.37       1      22 [.     212     233 ..     212     255 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00054
  RNA_helicase   1 iwlyGpsgeGKStlakeLakal 22 
                   ++lyGp+g+GK++la+  a++ 
    EFC36990.1 212 VLLYGPPGTGKTLLARACAAQT 233
                   689************9965554 PP

>> Prot_ATP_OB_N  Proteasomal ATPase OB N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00084      0.58      11      53 ..     107     151 ..      78     157 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00084
  Prot_ATP_OB_N  11 qdgtadVlvggrr.mrVavsPlvdaeeLrpGqeVlLn.EalvvVe 53 
                    ++++a + ++ r+ + ++v  lvd e+L+pG  V +n +++ v e
     EFC36990.1 107 KGKSAVIKTSTRQtIYLPVIGLVDSEDLKPGELVGVNkDSFLVLE 151
                    566677777777636799999**************9944555555 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   1.8      0.77   5.3e+02     128     173 ..      28      73 ..       3     120 .. 0.60
   2 ?    9.7   0.0   0.00094      0.65      18      41 ..     210     233 ..     195     323 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.77
      AAA_11 128 eiskeleklakelrafeeeeekeklkkskekskskleqerrklkke 173
                 ei+ +++ +++e++ f +e+++ + +++ +k+k k+++e+ kl+k+
  EFC36990.1  28 EIEHRSRLIDNEIHVFRNEKKRIQYEENTMKEKIKENVEKIKLNKQ 73 
                 4444444444444444444444444444444444444444444443 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00094
      AAA_11  18 eitliqGPPGtgKTktivellsql 41 
                 + +l+ GPPGtgKT    +  +q 
  EFC36990.1 210 KGVLLYGPPGTGKTLLARACAAQT 233
                 45799*********8777666665 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   1.7      0.11        77      34     119 ..      33     119 ..      31     161 .. 0.71
   2 ?    6.2   0.0     0.012       8.5      23      43 ..     212     232 ..     204     239 .. 0.83
   3 ?    1.1   0.0      0.45   3.1e+02     113     132 ..     263     282 ..     254     322 .. 0.68

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.11
    ATPase_2  34 taLlkeiienledkdkyviyyialreesiskldefieeeeekkklekalgiavpkaeleeilk.eksklvfkaielllekikkkgkk 119
                 ++L+ + i   ++ +k++ y  +  +e+i++  e+i+ +++  +l  ++ + ++++e eei++   s ++++  +   + ik + ++
  EFC36990.1  33 SRLIDNEIHVFRNEKKRIQYEENTMKEKIKENVEKIKLNKQLPYLVATVVEILETDENEEIIQdGSSVDLDEERKGKSAVIKTSTRQ 119
                 667777788888888888888888888888888888888888888888888888888888887656666666666555556555555 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.012
    ATPase_2  23 yfiYGpegsGKtaLlkeiien 43 
                 +++YGp g GKt L +  + +
  EFC36990.1 212 VLLYGPPGTGKTLLARACAAQ 232
                 789***********9988766 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.45
    ATPase_2 113 ikkkgkkiiiiiDelqklid 132
                 + +++   ii+iDel  ++ 
  EFC36990.1 263 LAREKAPAIIFIDELDAIGT 282
                 55565568899999998874 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   1.6      0.71   4.9e+02      37      96 ..       8      72 ..       3     106 .. 0.62
   2 ?    7.8   0.0    0.0063       4.4       7      37 ..     205     235 ..     202     248 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.71
                -SEEEEEET.TCEGGGB-HHHCCHCEEEE-SS--S-....TTSBHHHHHHHTCHHHHHHHSTTGG CS
                xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran 37 pteGeilld.gkdlkeqeleslrkeigvlpqepqlf....peltvrenesdeeiekalsklglke 96
                +t++e+l   g+d+   ++ + +++++ +  e ++f    ++++ +en+++e+i++ ++k++l++
  EFC36990.1  8 WTKDEVLETfGEDIACASTDEIEHRSRLIDNEIHVFrnekKRIQYEENTMKEKIKENVEKIKLNK 72
                56666644456666666666666666666666444400004444555577777777777777665 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0063
                 EEETTSEEEEEESTTSSHHHHHHHHTTSS-- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   7 klkegekvaivGenGaGKStLlkllagllkp 37 
                  +++ + v + G+ G+GK+ L+++ a ++k 
  EFC36990.1 205 GISPPKGVLLYGPPGTGKTLLARACAAQTKA 235
                 567778899**************99888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (428 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1425  (0.0794802); expected 358.6 (0.02)
Passed bias filter:                      798  (0.0445089); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              26  [number of targets reported over threshold]
# CPU time: 0.78u 0.36s 00:00:01.14 Elapsed: 00:00:00.56
# Mc/sec: 2305.22
//
Query:       EFC36991.1  [L=1399]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.83u 0.32s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 7925.28
//
Query:       EFC36992.1  [L=397]
Description: tyrosine aminotransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.8e-60  202.6   0.0    1.1e-59  202.5   0.0    1.0  1  Aminotran_1_2    Aminotransferase class I and II
      2e-05   23.3   0.0      3e-05   22.7   0.0    1.2  1  Cys_Met_Meta_PP  Cys/Met metabolism PLP-dependent enzyme
    3.6e-05   23.2   0.0    5.6e-05   22.6   0.0    1.3  1  Beta_elim_lyase  Beta-eliminating lyase
    4.5e-05   22.9   0.0    6.5e-05   22.4   0.0    1.1  1  DegT_DnrJ_EryC1  DegT/DnrJ/EryC1/StrS aminotransferase family
    0.00023   20.2   0.0    0.00049   19.2   0.0    1.5  2  Aminotran_5      Aminotransferase class-V
  ------ inclusion threshold ------
       0.17   12.1   0.0       0.28   11.4   0.0    1.4  1  DUF262           Protein of unknown function DUF262


Domain annotation for each model (and alignments):
>> Aminotran_1_2  Aminotransferase class I and II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  202.5   0.0   3.7e-63   1.1e-59       2     362 ..      24     386 ..      23     387 .. 0.91

  Alignments for each domain:
  == domain 1  score: 202.5 bits;  conditional E-value: 3.7e-63
                    EEEESSSSSTTSTTSSHHHHHHHHHHHHHHHHHTSTTST-BTTHHHHHHHHHHHHHCTCTTCHTTGGEGEEEESHHHHHHHHHHHHHHHTTT-EEE CS
  Aminotran_1_2   2 dvinLgsneylgdsgkptlpevakaekegalaggtlneygpidglpeleealakflgrseklklkreaavvvgsGagaliealifllklnpgdeil 97 
                     ++ L++++++  ++  t + v +a ++ a + g++n y p+ g +++++a+a  ++  +++++k +  vv +sGa+ +++++i++l +n gdeil
     EFC36992.1  24 SKLSLSIGDPTVFGNLKTDKMVEEAIIK-AVQEGKCNGYAPSMGRDDARKAVATRYS-LKNHSVKMS-DVVICSGASGALDICIQAL-CNEGDEIL 115
                    5889*********8889999999999*9.***************************9.788888899.9******************.8******* PP

                    EEESS-THHHHHHHHTTSEEEEEEBEETTTTEE-HHHHHHHHTTHHCTTETEEEEEEESS-TTT--B--HHHHHHHHHHHHHTTEEEEEEETTTTC CS
  Aminotran_1_2  98 vpdptyasyknilrlsggevvryplyseedfhldlealeealkeapegnkktkvilvesphNPtGtvatleeleklldlakkynlllfvDeaYagf 193
                    +p+p ++ y++ +   g+e  +y+l+s + +++dle+   ++++      kt+ ilv++p+NP+G+v++ ++l++++++a++ +l ++ De+Ya++
     EFC36992.1 116 LPQPGFSLYTTLAGSKGIEAKYYNLKSNDAWKVDLEHARSLVTS------KTRAILVNNPSNPCGSVYDAAHLKDIINFAEEFKLPIIADEIYADM 205
                    ********************************************......********************************************** PP

                    BSSSS.HTHHHHGGSTTSTTEEEEEESSSTTSSGGG-EEEEEE.EH.....HHHHHHHHHHHHHTS.SHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Aminotran_1_2 194 vfgsl.davatranveeepnllivgslsKafGlaGeRvGyilg.na.....avvsqlrklsrpfls.ssllqaavaaalsdallkqseleemrqrl 281
                     f+++ +++   a++ + + +l vg+ +K f ++G RvG+i++ ++      +++ +++l + +l   +l+q a+  + ++++    + ++  + l
     EFC36992.1 206 IFDETeKFIH-MAELTDTVPILSVGGIAKQFLVPGYRVGWIIIyDKmgymnQLRDGIQRLTTLILGaNTLVQGALPYIFEKVEPS--FYKNLNRSL 298
                    ***8877777.********************************655855555555555555555556666666666666666643..********* PP

                    HHHHHHHHHHHHHS.TEEEECCSCSSEEEEEETHH.......CHHHHHHHHHHTCTEEEEEGGGGTSTTEEEEECTTS-HHHHHHHHHH CS
  Aminotran_1_2 282 qkrrkelrdeLael.glkvlasqsgmflltdlsae.......takelskkLleevgvyvtpgtsftvpgrlRitvAglteeeleelvea 362
                    ++++++  +++ ++ gl+ + +q++m+++ +++         ++ e+s  Ll+e+ ++v+pg++f++++++R+   + ++++l e+ ++
     EFC36992.1 299 KESSDYTAERISNIkGLSAIRPQGAMYCMIGIDIDmfddqinDDVEFSSLLLKEESLIVLPGQCFRMKNFFRVVT-CPSKNDLVEAYDR 386
                    *************9****************************9******************************99.8888888777766 PP

>> Cys_Met_Meta_PP  Cys/Met metabolism PLP-dependent enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0     1e-08     3e-05      71     176 ..      90     202 ..      66     209 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 1e-08
                      EEESSHH.HHHHHHHHTTS-TTEEEEEESTSSHHHHHHHHHTHHHTTCEEEEEST.......TSHHHHHHHCCTTEEEEEEESS-TTTT----. CS
  Cys_Met_Meta_PP  71 lavssGm.aAiaaailallkaGdeivvsddlYggtqrllkkvlkklgievkfvdt.......sdleelekaikentklvylEtptnpllkvvD. 155
                      +++ sG  +A++  i+al+++Gdei++ +  +    +l ++++   gie+k+++         dle+ ++ ++++t+++++  p+np  +v D 
       EFC36992.1  90 VVICSGAsGALDICIQALCNEGDEILLPQPGF----SLYTTLAGSKGIEAKYYNLksndawkVDLEHARSLVTSKTRAILVNNPSNPCGSVYDa 179
                      3455554168999*************998655....56666666666777776662222233566666778899****************9994 PP

                      ..HHHHHHHHHHTT-EEEEEGTT CS
  Cys_Met_Meta_PP 156 ..iekiaklakkagvlvvvDntf 176
                        +++i+++a + +++++ D  +
       EFC36992.1 180 ahLKDIINFAEEFKLPIIADEIY 202
                      44567888888889999999765 PP

>> Beta_elim_lyase  Beta-eliminating lyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   1.9e-08   5.6e-05      57     167 ..      97     199 ..      38     201 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 1.9e-08
                      HHHHHHHHHHH--TTEEEEEETT-HHHHSSTTHHHHCC--EEEEE-EBTTTBE-HHHHHHHS--S-TTS-EEEEEEEESSBTTTTTB---HHHH CS
  Beta_elim_lyase  57 taAnsillkillqrgeevivtepahihfdetgaiaelagvklrdlknkeaGkmdlekleaaikevgaheekiklisltvTnntagGqvvsleel 150
                       +A  i++++l++ g+e+++ +p+    ++  + + ++ +k  +lk+++a k+dle  +++++       k+++i++ +  n  +G v+  ++l
       EFC36992.1  97 SGALDICIQALCNEGDEILLPQPGFSLYTTLAGSKGIE-AKYYNLKSNDAWKVDLEHARSLVTS------KTRAILVNNPSNP-CGSVYDAAHL 182
                      5677899*****************99999988888886.4599******9*************9......699*********5.********** PP

                      HHHHHHHHHCT-EEEEE CS
  Beta_elim_lyase 151 revaaiakkygiplhlD 167
                      + + ++a++ ++p++ D
       EFC36992.1 183 KDIINFAEEFKLPIIAD 199
                      *************9988 PP

>> DegT_DnrJ_EryC1  DegT/DnrJ/EryC1/StrS aminotransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.0   2.2e-08   6.5e-05      39     144 ..      88     199 ..      79     203 .. 0.83

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 2.2e-08
                      SEEEEESSHHHHHHHHHHHTTTTTT-EEEEESSS-THHHHHHHHTT-EEEEE-B-T.TTSSB-GGGCGGG--TTEEEEE...EB-GGGB---HH CS
  DegT_DnrJ_EryC1  39 khaiavssGtaAlhlaLralgvgpgdeVIvpsltFvatanavlelgakpvfvDvdp.dtynidpaaieaaitertkaIl...pVhlyGqvadmd 128
                        ++ +s ++ Al + ++al   +gde++ p+ +F      +   g ++ + + +  d + +d +++++++t++t+aIl   p +  G v d +
       EFC36992.1  88 SDVVICSGASGALDICIQALCN-EGDEILLPQPGFSLYTTLAGSKGIEAKYYNLKSnDAWKVDLEHARSLVTSKTRAILvnnPSNPCGSVYDAA 180
                      55677788899********854.48***********999999**********99861569******************9333456789888877 PP

                      HHHHH...HHHCT-EEEEE CS
  DegT_DnrJ_EryC1 129 alkai...aakhglkvieD 144
                      +lk+i   a++ +l++i D
       EFC36992.1 181 HLKDIinfAEEFKLPIIAD 199
                      7777655589999999998 PP

>> Aminotran_5  Aminotransferase class-V
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   1.6e-07   0.00049      59     165 ..      86     186 ..      56     199 .. 0.83
   2 ?   -3.3   0.0       1.1   3.2e+03     277     302 ..     295     320 ..     287     337 .. 0.77

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 1.6e-07
                  STGGGEEEESSHHHHHHHHHHHCCCC-TTTSEEEEETTSHGGGTHHHHHHHHHHTEEEEEE..EBETTSCBEGGGHHHH--TTEEEEEEESBETTTTE CS
  Aminotran_5  59 eseeeiiftsGtteainlvalslarslkpgdeivvteaehhanlvpwqelakrtgakvkvi..pldeegeldldelekllnektklvaithvsnvtGt 154
                  +  ++++ +sG++ a+ + +++l    ++gdei++ + +    +     la  +g++ k++  + ++ +++dl+++++l++ kt+++ ++  sn  G 
   EFC36992.1  86 K-MSDVVICSGASGALDICIQAL---CNEGDEILLPQPGFSLYT----TLAGSKGIEAKYYnlKSNDAWKVDLEHARSLVTSKTRAILVNNPSNPCGS 175
                  3.4799*****************...9**********9986555....777778888887622678899***************************** PP

                  B--HHHHHHHH CS
  Aminotran_5 155 iqpveeigkla 165
                  + + +++++++
   EFC36992.1 176 VYDAAHLKDII 186
                  99998887665 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.1
                  HHHHHHHHHHHHHHHCTSTTEEEES. CS
  Aminotran_5 277 ekhekelaeyllerlkslpgvrlygp 302
                  ++  ke ++y+ er+++++g+  + p
   EFC36992.1 295 NRSLKESSDYTAERISNIKGLSAIRP 320
                  55667888999999999999988765 PP

>> DUF262  Protein of unknown function DUF262
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   9.2e-05      0.28      63      95 ..     259     303 ..     236     354 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 9.2e-05
      DUF262  63 DGQQRltTltlllaa..........t..keesekriknleaeiek 95 
                 DG QRltTl+l ++           +  + + +k++++ ++e+ +
  EFC36992.1 259 DGIQRLTTLILGANTlvqgalpyifEkvEPSFYKNLNRSLKESSD 303
                 ***********9999554444433303322222223222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       492  (0.0274416); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2289.65
//
Query:       EFC36993.1  [L=202]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.074   12.9   3.2        0.1   12.4   3.2    1.2  1  DUF4422   Domain of unknown function (DUF4422)
      0.078   13.3   0.2      0.095   13.1   0.2    1.2  1  DUF778    Protein of unknown function (DUF778)


Domain annotation for each model (and alignments):
>> DUF4422  Domain of unknown function (DUF4422)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   3.2   1.1e-05       0.1      72     133 ..      36     101 ..      30     151 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.1e-05
     DUF4422  72 lvHYRRyfsfkkkkekkakllkeekkekkilseeeiekllkkydiilpkkrk....lkieslyeqY 133
                 +  YR yf ++ k+e+ ++++++e +++  +++++ e+l+++  i++p++++    +++e ++++ 
  EFC36993.1  36 IQYYRKYFVQQPKRENLHTITNNEIIQEFPIEKSSNEQLVSNNSILVPNQQQqpiiMQNERVQKHN 101
                 678**********988888999**************************999844333333333332 PP

>> DUF778  Protein of unknown function (DUF778)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.2   1.1e-05     0.095      57      99 ..      71     113 ..      22     140 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.1e-05
      DUF778  57 arrtrrePfklltqggkqailvlwerllallqPdev.....stcsaqt 99 
                   +   + + l++  ++q+i++++er ++ +qP +      +     +
  EFC36993.1  71 NEQLVSNNSILVPNQQQQPIIMQNERVQKHNQPMKSllklgR-----K 113
                 4555556678999********************876333331.....2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (202 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1906  (0.106308); expected 358.6 (0.02)
Passed bias filter:                      632  (0.0352502); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1239.46
//
Query:       EFC36994.1  [L=183]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-11   42.9   0.0    6.5e-11   42.5   0.0    1.1  1  DUF1757   Protein of unknown function (DUF1757)


Domain annotation for each model (and alignments):
>> DUF1757  Protein of unknown function (DUF1757)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.5   0.0   3.6e-15   6.5e-11      16     141 ..      32     165 ..      18     170 .. 0.85

  Alignments for each domain:
  == domain 1  score: 42.5 bits;  conditional E-value: 3.6e-15
     DUF1757  16 adipspkvElaihvtfksvqllallGgvilgPivrlllkkk.......rnsqkiirsavkkgqggallglvvgPvltllrlkdlseeelydrcYrlRfn 107
                 ++ip+pk+ +  hv +k +ql+++lG  +  Pi    ++         +  ++i+ +  +++  g  +g+v+  ++ + r+++ +++++ dr +r+  n
  EFC36994.1  32 QKIPNPKMAVFNHVVLKGIQLGGFLG-ALYTPIHFATKQYIlkkplahSLGESIKIKLPRFISIGTSIGFVLTAAMYYGRTRTFTQNNFDDRAFRIAHN 129
                 69************************.8999998776654455567766667788888899999999******************************** PP

     DUF1757 108 keqlrvDR..tavvlaavgflskrfqgaviGldlgl 141
                 k ++ +D    a vl+ ++f + + + +++G ++g 
  EFC36994.1 130 KMNMFWDQiwVASVLGSAIFFTLKKKPMIVGPMIGN 165
                 ********7756666777777788888888877775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 1178.88
//
Query:       EFC36995.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-16   59.3   0.0    2.8e-13   50.0   0.0    2.3  2  TPR_12    Tetratricopeptide repeat
      2e-07   30.5   0.0       0.04   13.7   0.0    3.5  3  TPR_1     Tetratricopeptide repeat
    7.2e-07   28.9   0.0     0.0034   17.2   0.0    3.3  3  TPR_10    Tetratricopeptide repeat
    2.6e-06   27.1   0.0       0.23   11.6   0.0    3.4  3  TPR_2     Tetratricopeptide repeat
    4.8e-05   23.2   1.8       0.17   12.2   0.1    3.4  4  TPR_8     Tetratricopeptide repeat
     0.0007   19.1   0.0      0.001   18.5   0.0    1.3  1  TPR_MalT  MalT-like TPR region
     0.0022   17.4   0.0       0.84    9.2   0.0    2.6  2  SHNi-TPR  SHNi-TPR
  ------ inclusion threshold ------
       0.11   12.6   0.1         31    4.9   0.0    2.9  3  TPR_7     Tetratricopeptide repeat
       0.42   10.9   1.8       0.73   10.2   0.2    2.1  2  DUF2811   Protein of unknown function (DUF2811)


Domain annotation for each model (and alignments):
>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0    0.0028       5.5       9      35 ..      65      91 ..      60      99 .. 0.75
   2 !   50.0   0.0   1.4e-16   2.8e-13       5      75 ..     100     169 ..      96     171 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0028
      TPR_12  9 laavlrrlgrydeAlellekaleiarr 35
                +++v++ lg+ + Al+ + +a   a++
  EFC36995.1 65 IGLVYQSLGNDELALSEFMEAKKFAQA 91
                678888888888888888888777665 PP

  == domain 2  score: 50.0 bits;  conditional E-value: 1.4e-16
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaia 75 
                  l+ +++v ++ g++  A++++ k+lei++ +lG+   +ta +++n + +++  g++ +A++++++ + i+
  EFC36995.1 100 PLSCIGSVFYHVGQFLLAQKYYTKSLEIRQTYLGE-GVDTAVSMINVAACLQCVGDFPAAHDMYNKGISIL 169
                 57789************************999986.78****************************99886 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.1    0.0043       8.5       5      27 ..      63      85 ..      61      90 .. 0.81
   2 !   13.7   0.0     2e-05      0.04       5      34 .]     102     131 ..     100     131 .. 0.91
   3 !    6.3   0.0    0.0046       9.3       5      30 ..     143     168 ..     139     169 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0043
                HHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1  5 ynlGnayfklgkydeAleyyekA 27
                + +G++y++lg+ + Al  + +A
  EFC36995.1 63 CAIGLVYQSLGNDELALSEFMEA 85
                668*********99999766555 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2e-05
                 HHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekALelnPnn 34 
                   +G ++++ g++  A +yy k Le++ ++
  EFC36995.1 102 SCIGSVFYHVGQFLLAQKYYTKSLEIRQTY 131
                 56899*********************9875 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0046
                 HHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekALel 30 
                  n +++++  g++  A + y+k +++
  EFC36995.1 143 INVAACLQCVGDFPAAHDMYNKGISI 168
                 68899*****************9976 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.13   2.6e+02       8      28 ..      65      85 ..      63      96 .. 0.83
   2 !    6.0   0.0    0.0057        11       7      38 ..     103     134 ..     101     135 .. 0.86
   3 !   17.2   0.0   1.7e-06    0.0034       1      41 [.     138     178 ..     138     179 .. 0.98

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.13
      TPR_10  8 LanalrqrgrydeAealleea 28
                ++ +++++g+ + A+  + ea
  EFC36995.1 65 IGLVYQSLGNDELALSEFMEA 85
                6899******99998877666 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0057
      TPR_10   7 NLanalrqrgrydeAealleealairrrllGp 38 
                  ++ + +++g++  A +++ ++l+ir+  lG+
  EFC36995.1 103 CIGSVFYHVGQFLLAQKYYTKSLEIRQTYLGE 134
                 56788889999999*************99996 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 1.7e-06
      TPR_10   1 tAsslnNLanalrqrgrydeAealleealairrrllGpdHP 41 
                 tA s+ N a+ l+ +g++ +A +++ + ++i  + lGp HP
  EFC36995.1 138 TAVSMINVAACLQCVGDFPAAHDMYNKGISILNEKLGPSHP 178
                 899*************************************9 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.1    0.0034       6.7       6      29 ..      64      87 ..      60      91 .. 0.89
   2 !   11.6   0.0   0.00012      0.23       4      32 ..     101     129 ..      99     131 .. 0.90
   3 ?    4.5   0.0     0.023        46       5      30 ..     143     168 ..     139     171 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0034
       TPR_2  6 nlGlayyklgdyeeAleafekAle 29
                ++Gl+y  lg+ e Al  f +A +
  EFC36995.1 64 AIGLVYQSLGNDELALSEFMEAKK 87
                78****************999865 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00012
       TPR_2   4 lynlGlayyklgdyeeAleafekAleldP 32 
                 l ++G + y+ g++  A +++ k+le+  
  EFC36995.1 101 LSCIGSVFYHVGQFLLAQKYYTKSLEIRQ 129
                 67899*********************965 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.023
       TPR_2   5 ynlGlayyklgdyeeAleafekAlel 30 
                  n + ++   gd+  A++ ++k +++
  EFC36995.1 143 INVAACLQCVGDFPAAHDMYNKGISI 168
                 67899999**************9876 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.96   1.9e+03      10      23 ..      26      39 ..      25      42 .. 0.79
   2 !   12.2   0.1   8.4e-05      0.17       5      31 ..      63      89 ..      61      92 .. 0.90
   3 !    8.4   0.0    0.0013       2.7       7      32 ..     104     129 ..     104     131 .. 0.85
   4 ?   -4.2   0.0         9   1.8e+04      24      29 ..     162     167 ..     158     168 .. 0.65

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.96
                HHHHTT-HHHHHHH CS
       TPR_8 10 iylklgdyeeAkey 23
                ++++l++++e+++ 
  EFC36995.1 26 LHEQLERKKEMEKE 39
                78999999999875 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 8.4e-05
                HHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8  5 ynlgsiylklgdyeeAkeyyekaleld 31
                + +g++y++lg+ e A + +++a + +
  EFC36995.1 63 CAIGLVYQSLGNDELALSEFMEAKKFA 89
                789*******************98865 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0013
                 HHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   7 lgsiylklgdyeeAkeyyekaleldp 32 
                 +gs+    g++  A++yy k le+++
  EFC36995.1 104 IGSVFYHVGQFLLAQKYYTKSLEIRQ 129
                 5777788899999**********986 PP

  == domain 4  score: -4.2 bits;  conditional E-value: 9
                 HHHHHH CS
       TPR_8  24 yekale 29 
                 y+k ++
  EFC36995.1 162 YNKGIS 167
                 677666 PP

>> TPR_MalT  MalT-like TPR region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   5.2e-07     0.001      44     157 ..      63     175 ..      38     183 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 5.2e-07
    TPR_MalT  44 avlGeasllqGdleaAlqalqeaeklarqadslhvallallqqaeilvaqGrLheAletyeqalqlateqglqqlplvgfllvlladllyEwndLeeAe 142
                  ++G +++  G+ e Al+ ++ea k+a++ + ++ +++  + ++ +  + G++  A + y+++l+  ++  ++ + ++  +  + a  l   +d+ +A+
  EFC36995.1  63 CAIGLVYQSLGNDELALSEFMEAKKFAQAMNDSDSSIPLSC-IGSVFYHVGQFLLAQKYYTKSLEIRQTYLGEGVDTAVSMINV-AACLQCVGDFPAAH 159
                 467999****************************8888777.67777777************************9988877555.6777779******* PP

    TPR_MalT 143 qhlqeGielleq.lep 157
                 ++ ++Gi +l + l+p
  EFC36995.1 160 DMYNKGISILNEkLGP 175
                 ********66541555 PP

>> SHNi-TPR  SHNi-TPR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0    0.0063        13      12      28 ..      83      99 ..      82     101 .. 0.89
   2 !    9.2   0.0   0.00042      0.84      16      35 ..     113     132 ..     105     133 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0063
    SHNi-TPR 12 lEnenFpqAveDlrkaL 28
                +E+ +F qA  D ++++
  EFC36995.1 83 MEAKKFAQAMNDSDSSI 99
                8999**********997 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00042
    SHNi-TPR  16 nFpqAveDlrkaLeLreqll 35 
                 +F  A++ ++k+Le+r+++l
  EFC36995.1 113 QFLLAQKYYTKSLEIRQTYL 132
                 67779999*********986 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.016        31       3      20 ..      63      80 ..      62      85 .. 0.90
   2 ?    4.2   0.0     0.026        51       8      30 ..     107     129 ..     104     135 .. 0.74
   3 ?   -2.5   0.0       3.7   7.4e+03       6      18 ..     146     158 ..     142     165 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.016
       TPR_7  3 lnLarlysrlGdyeeAie 20
                ++++ +y++lG+ e A++
  EFC36995.1 63 CAIGLVYQSLGNDELALS 80
                689**********99976 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.026
       TPR_7   8 lysrlGdyeeAielyeqsLaltk 30 
                 ++  +G++  A ++y++sL+++ 
  EFC36995.1 107 VFYHVGQFLLAQKYYTKSLEIRQ 129
                 5556666667999*******986 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 3.7
       TPR_7   6 arlysrlGdyeeA 18 
                 a + + +Gd+  A
  EFC36995.1 146 AACLQCVGDFPAA 158
                 6667779999777 PP

>> DUF2811  Protein of unknown function (DUF2811)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.2   0.00036      0.73       8      27 ..       8      27 ..       6      31 .. 0.89
   2 ?   -1.5   0.1       1.6   3.2e+03      36      53 ..     113     132 ..     111     134 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00036
     DUF2811  8 eeLheslkkflethpnWDqd 27
                e L + + +fle+  nWD +
  EFC36995.1  8 EILDSRMDDFLESTKNWDLH 27
                679999************86 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.6
     DUF2811  36 lFLlqngssd..ravarvYl 53 
                 +FLl +       +++++Yl
  EFC36995.1 113 QFLLAQKYYTksLEIRQTYL 132
                 68876654332267788887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1038  (0.057895); expected 358.6 (0.02)
Passed bias filter:                      617  (0.0344135); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1329.48
//
Query:       EFC36996.1  [L=1143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.5e-44  150.1   1.6    3.9e-43  147.5   1.6    2.1  1  SNF2_N         SNF2 family N-terminal domain
      3e-18   66.2   1.2    2.6e-17   63.1   0.1    2.9  3  Helicase_C     Helicase conserved C-terminal domain
    1.1e-07   32.1   0.2    1.1e-07   32.1   0.2    3.9  3  ResIII         Type III restriction enzyme, res subunit
     0.0024   17.1   0.2     0.0024   17.1   0.2    2.7  3  ERCC3_RAD25_C  ERCC3/RAD25/XPB C-terminal helicase
  ------ inclusion threshold ------
        2.9    8.5  10.5          3    8.4   1.1    4.0  4  Acyl-CoA_ox_N  Acyl-coenzyme A oxidase N-terminal


Domain annotation for each model (and alignments):
>> SNF2_N  SNF2 family N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  147.5   1.6   1.1e-46   3.9e-43      35     349 ..     261     585 ..     218     586 .. 0.82

  Alignments for each domain:
  == domain 1  score: 147.5 bits;  conditional E-value: 1.1e-46
                 ..............HHHHHTT--EEE---TTS--HHHHHHHHH...HHTTTS---.......S-EEEE--HHHHHHHHHHHHHH-TTS-EEE--SSHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N  35 iyvnpatgevveesaeakqsvrGGiLaDemGLGKTvqvlalilaqrakeekdkekkrkdtlagptLivvPaslldqWeneierhvsssalrvlvyggqk 133
                  y  + +g+   +  ++  + rGGiLaDemGLGKTvqv a++       ++++++         +Li++P s+l+ W +e+++++++ ++ v++  ++k
  EFC36996.1 261 LYSFQKEGIKWLNTRFNADKYRGGILADEMGLGKTVQVSAFLG---GLAQSKTRR---------YLIIAPLSVLQTWASELDKWAPNIKTFVFHNLSSK 347
                 555566666666777888999**********************...556666666.........9*************************999988877 PP

                 H----------..-------EEEE-HHHHHHHT......TTS-S-S-SEEEES-GGGT--TTSHHHHHHHH---S-EEEE-S--SSS-HHHHHHHHH.. CS
                 xxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.. RF
      SNF2_N 134 kmkkkntkvap..klladydvvittYdvlsreaelqkkrsvlkqvewkrvvlDEghtlknstskaaeavskLstsnrwiltGTPiqnsledlygLlk.. 228
                 ++ ++  + ++  + +++   +itt+ +l + +  ++  s   ++e +  ++DE+h++kn ++ +++ ++k+ ++ + +ltGTPi n+l +++++ +  
  EFC36996.1 348 EQYNSMARDFHgcAKQQKSAAIITTFRTLVTYT--VTLASLCAKQEFDITIVDEAHQIKNDQTGISKNLRKIGSRAKFCLTGTPIMNKLMEMWSIYDyv 444
                 755555555551145566679*********766..78889999999*************************************************9833 PP

                 HH-TTTT--HHHHHHHTHHHHH............HHHHHHHHHHHTT-STTEE---GGGT...................--S---EEEEEEEEE--HHH CS
                 xxxxxxxxxxxxxxxxxxxxxx............xxxxxxxxxxxxxxxxxxxxxxxxxx...................xxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 229 fLreepfgekqtfdkllqrpie............aqaekgrsrLlqllqrlmlrrakkdv...................eknlPpkteeiiflklskve 296
                 f + +++g+k+ f++ ++r i                +k ++++++l+q+++lrr k++v                   ++++ +k+e ++++ lsk +
  EFC36996.1 445 FYGDNILGDKKEFKTNFERSIVksrkrdasntekVLGNKLSQQMRSLIQPYILRRHKNQVlesdhnvglgtilkkqstgKAKISQKNELVLWCYLSKTQ 543
                 55678****************99******99998889999**********99999999999888888887777665555559***************** PP

                 HHHHH....................HHHHHH-HH.H-HHHHHHHHHHHHH---X CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxx RF
      SNF2_N 297 rksYnrllevlrkkalakllkrseaalksssksk.ekilelllelrqacnhpql 349
                  ++Y+   ++l  ++++++l ++      s   + + i++ l  l+  cnhp+l
  EFC36996.1 544 DRVYT---QYLKSEIVKQILGKK------S---NrSCIFSALSTLKMLCNHPRL 585
                 *****...444455555444442......2...214488889999999999986 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.33   1.2e+03      36      82 ..     347     394 ..     310     412 .. 0.69
   2 !   63.1   0.1   7.4e-21   2.6e-17       2     111 .]     632     745 ..     631     745 .. 0.94
   3 ?   -3.2   0.0         3   1.1e+04      73      91 ..    1026    1044 ..    1025    1049 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.33
                 HHHTTSTEEEESTTSTHHHHHHHHHHHH.TTSSSEEEESGGGTSSSTS CS
  Helicase_C  36 lekkgikvavlhgelpqnereeileqfn.kgesdvLiatdvaerGidi 82 
                 +e+ +  +  +hg  +q++  +i++ f+   +++v +a+  a +  di
  EFC36996.1 347 KEQYNSMARDFHGCAKQQKSAAIITTFRtLVTYTVTLASLCAKQEFDI 394
                 344467777788888889999999999833555566666666665555 PP

  == domain 2  score: 63.1 bits;  conditional E-value: 7.4e-21
                 HHHHHHHHH.HHTTTTSEEEEEESSHHHHHH.HHHHHHHTTSTEEEESTTSTHHHHHHHHHHHH.TTSSS.EEEESGGGTSSSTSTTESEEEESSSSSS CS
  Helicase_C   2 kleallell.kleeeggkilifvntidrlek.vklllekkgikvavlhgelpqnereeileqfn.kgesd.vLiatdvaerGidipkvnlVinfdlprn 96 
                 kl+++++ll ++++ g+++lif++++++l+   ++++e+ ++k+++++g   ++er++ ++ f+ ++ +  +L++t  ++ G++++ ++ Vi +d+ +n
  EFC36996.1 632 KLQIIVKLLkEHKKTGHRTLIFSQYKTMLDIvERIITEHLKLKTLRIDGGVAAKERQARVDLFQkNNMYScFLLTTGSGGVGLTLTAADRVILIDPHWN 730
                 8999*****9999****************99878888888***********************95566778**************************** PP

                 HHHHHHHHTTSSSTT CS
  Helicase_C  97 vtsyiqriGRtgRag 111
                 ++  +q+++R++R+g
  EFC36996.1 731 PAVDQQAVDRAYRVG 745
                 *************87 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 3
                  SGGGTSSSTSTTESEEEES CS
  Helicase_C   73 tdvaerGidipkvnlVinf 91  
                  ++ a+ +idi++ ++V n 
  EFC36996.1 1026 SNGASSSIDITDDTVVSNN 1044
                  677999****998888765 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   4.5       1.3   4.8e+03      73     141 ..      68     130 ..      59     211 .. 0.68
   2 !   32.1   0.2     3e-11   1.1e-07       3     169 ..     260     429 ..     258     431 .. 0.80
   3 ?   -0.9   0.1      0.39   1.4e+03      72     118 ..     601     663 ..     590     710 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.3
                 HGGGGTGG....GEEEESSS-B--.......-SEEEEEHHHHHHTH........HHHTTT-SEEEEETG CS
      ResIII  73 efkkflseaykeigkkvsgdkkkakekdstnkkilvttiqsldadseeeeeeseellrdrfdviiiDEa 141
                 +fkk+++++++ i k++++ +k++   ++ ++   v+ i+ ++ +s   +ee+   ++++  +i  DE 
  EFC36996.1  68 NFKKVKQDNRSTIHKSIDSFRKMK---EAGHSASKVSHISVISDSS---DEEKSPPSNNSAILISSDEE 130
                 555555555555555555555555...7777777777777777777...55555555555555555554 PP

  == domain 2  score: 32.1 bits;  conditional E-value: 3e-11
                 EE-HHHHHHHHHHT......TTSEEEEEESTTSTHHHHHHHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG..........GEEEESSS-B- CS
      ResIII   3 elreyQeeaienlleklkskrdkrglikmaTGtGKTlvaaklierllkkgkeekflflvprkslleqtleefkkflseayke......igkkvsgdkkk 95 
                 +l++ Q+e i+ l   +++++ + g+++ + G GKT+   ++   l++++  ++ l+++p +s+l+ + +e+ k++++ +++       ++ ++     
  EFC36996.1 260 KLYSFQKEGIKWLNTRFNADKYRGGILADEMGLGKTVQVSAFLGGLAQSKT-RRYLIIAP-LSVLQTWASELDKWAPNIKTFvfhnlsSKEQYN----- 351
                 68899999999999999988888999*************999999999866.46666666.89**************99999755544333333..... PP

                 -.............-SEEEEEHHHHHHTH........HHHTTT-SEEEEETGGGTTS..TTTHHHHHT---SEEEEEESS- CS
      ResIII  96 a......kekdstnkkilvttiqsldadseeeeeeseellrdrfdviiiDEaHrlgak.kswreilekfkeavllglTATp 169
                 +         +++++  ++tt  +l               +++fd+ i+DEaH ++ + + + + l+k+ +  ++ lT+Tp
  EFC36996.1 352 SmardfhGCAKQQKSAAIITTFRTLVTYT---VTLASLCAKQEFDITIVDEAHQIKNDqTGISKNLRKIGSRAKFCLTGTP 429
                 24455465566778888889999998888...889999*****************99743666667888888899999999 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.39
                 HHGGGGTGG.............GEEEESSS-B--..............-SEEEEEHHHHHHTH CS
      ResIII  72 eefkkflseayke.........igkkvsgdkkka.......kekdstnkkilvttiqsldads 118
                 e+f++f+se +++          ++ +++ +k +       ++k++ ++ +++++++++  + 
  EFC36996.1 601 EAFENFISEGDDKdyldtsgmtCKELIEESSKLQiivkllkEHKKTGHRTLIFSQYKTMLDIV 663
                 567777776666666666666333334444444466777755566667777777777766555 PP

>> ERCC3_RAD25_C  ERCC3/RAD25/XPB C-terminal helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   1.2      0.57     2e+03     209     235 ..     169     195 ..     123     223 .. 0.47
   2 ?   -3.3   0.0       1.2   4.2e+03      15      36 ..     535     559 ..     526     567 .. 0.71
   3 !   17.1   0.2   6.6e-07    0.0024      40     168 ..     627     756 ..     611     834 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.57
  ERCC3_RAD25_C 209 ystkeeqkellqkvlaakdeeaeeeel 235
                    + ++e+ +++l+k+ ++k +e+e e+ 
     EFC36996.1 169 VVSPEKVSRILRKTREKKLSERELEDF 195
                    444444444555444444333222211 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.2
  ERCC3_RAD25_C  15 vWcpmta...efykeylkakskkkk 36 
                    +Wc +++     y++ylk++  k+ 
     EFC36996.1 535 LWCYLSKtqdRVYTQYLKSEIVKQI 559
                    6887754222689999999887765 PP

  == domain 3  score: 17.1 bits;  conditional E-value: 6.6e-07
  ERCC3_RAD25_C  40 vmnpnkfracefLikyhekrgDkiivfs......DnvfaLkeyakklkkpyiyGetseaerlkilqkfkknpkvntiflsk.vgDtsiDlPeanvl 128
                    +  ++k++++  L+k h+k g + ++fs      D v  + +   klk   i G ++ +er++ ++ f+kn+ +++ +l    g   + l  a  +
     EFC36996.1 627 IEESSKLQIIVKLLKEHKKTGHRTLIFSqyktmlDIVERIITEHLKLKTLRIDGGVAAKERQARVDLFQKNNMYSCFLLTTgSGGVGLTLTAADRV 722
                    45789***********************33333333334444556788899***********************9988865267788999999999 PP

  ERCC3_RAD25_C 129 iqisshfgsrrqeaqrlGriLrakkksneeefnaffYsLv 168
                    i i+ h      + q + r  r  ++     +n   Y L+
     EFC36996.1 723 ILIDPHWNPA-VDQQAVDRAYRVGQT-----KNVVTYRLI 756
                    9999987543.223334444333333.....344445555 PP

>> Acyl-CoA_ox_N  Acyl-coenzyme A oxidase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.49   1.7e+03      31      68 ..      60      97 ..      40     116 .. 0.80
   2 ?    8.4   1.1   0.00084         3       2      74 ..     172     244 ..     171     264 .. 0.73
   3 ?   -2.4   0.0       1.8   6.6e+03      38      54 ..     341     357 ..     334     368 .. 0.77
   4 ?    3.5   0.1     0.028     1e+02      16      69 ..     597     648 ..     588     672 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.49
                   GGS-SSTGGGS-HHHHHHHHHHHHHHHHHHHHHTTSBT CS
  Acyl-CoA_ox_N 31 efddaedyyflsreeryeealrkatrllkklrelqier 68
                       +++ +f   ++  ++++ k++  ++k++e +++ 
     EFC36996.1 60 SSGSEKQTNFKKVKQDNRSTIHKSIDSFRKMKEAGHSA 97
                   4555688999999999999*************998754 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00084
                    HHHHHHHHHTSHHHHHHHHHHHHHHCT-GGGS-SSTGGGS-HHHHHHH.HHHHHHHHHHHHHH.TTSBTTCHHHH CS
  Acyl-CoA_ox_N   2 veeltvllaggeeklerrrelesllesdpefddaedyyflsreeryee.alrkatrllkklre.lqierkeseee 74 
                    +e+ +++l + +ek    rele+++  + e ++ e+ +    ee yee  ++k+t+++++++   +++++  +++
     EFC36996.1 172 PEKVSRILRKTREKKLSERELEDFIVHEDEDEE-EEESDKEGEEEYEEkRAQKTTNMAELIDVgNGWKKD-ADDD 244
                    789999************************999.666666666666551689999999998873344333.3333 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 1.8
                    GGGS-HHHHHHHHHHHH CS
  Acyl-CoA_ox_N  38 yyflsreeryeealrka 54 
                    +++ls +e+y++ +r +
     EFC36996.1 341 FHNLSSKEQYNSMARDF 357
                    68999999999887765 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.028
                    HHHHHHHHHHHCT-GGGS-SSTGGGS-HHHHHHHHHHHHHHHHHHHHHTTSBTT CS
  Acyl-CoA_ox_N  16 lerrrelesllesdpefddaedyyflsreeryeealrkatrllkklrelqierk 69 
                    +++ ++ e+++++  + d   d + ++ +e++ee+  k+  ++k+l+e++++ +
     EFC36996.1 597 VNEDEAFENFISEGDDKDY-LDTSGMTCKELIEESS-KLQIIVKLLKEHKKTGH 648
                    5666788888888888888.99***********985.78889999999987543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1604  (0.089464); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.26s 00:00:00.90 Elapsed: 00:00:00.42
# Mc/sec: 8263.29
//
Query:       EFC36997.1  [L=308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        8.9    6.6  10.3       0.19   12.0   1.0    2.4  2  DUF4064   Protein of unknown function (DUF4064)


Domain annotation for each model (and alignments):
>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   1.0   1.1e-05      0.19      11      79 ..      20      89 ..      15      95 .. 0.71
   2 ?   -1.5   2.5      0.17     3e+03      20      69 ..     245     283 ..     226     306 .. 0.49

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.1e-05
     DUF4064 11 IGgilgillglllllflfllssgefsqeltee.qalsgedasavleflstlli.vlgvialiaivlgivga 79
                +G++++i ++++ l+ ++++ss+  ++   ++ ++++ +d++a l+   + ++ + + + ++  +lg+v++
  EFC36997.1 20 LGICFSIAFAIWSLFLFIVSSSDTATNR-PNMiSPNPLADSTACLGRTLVNMMlAVTCLEFLGVILGFVAM 89
                79************99666666554444.344688888888888865544444255555778888888887 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.17
     DUF4064  20 glllllflfllssgefsqelteeqalsgedasavleflstllivlgvial 69 
                 ++ll++++f     +f+ + +          + +++++s +li+ +v+ +
  EFC36997.1 245 TILLVFMAFY----NFESQCY-------VQYPVIYDMISPFLIAQFVYTV 283
                 2222222222....2222221.......2223344444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       948  (0.0528752); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1921.73
//
Query:       EFC36998.1  [L=281]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      2e-18   66.0   0.2    8.2e-18   64.1   0.3    2.1  2  TBPIP           TBPIP/Hop2 winged helix domain
    3.8e-08   33.3   0.1    3.8e-08   33.3   0.1    2.5  2  LZ3wCH          Leucine zipper with capping helix domain
  ------ inclusion threshold ------
       0.16   12.2   6.3       0.26   11.6   0.1    2.9  3  TFIIE_beta      TFIIE beta subunit core domain
       0.22    9.9   9.9        0.4    9.1   9.9    1.4  1  MCM_bind        Mini-chromosome maintenance replisome factor
        1.4    8.6   6.6        2.6    7.7   6.6    1.4  1  DUF789          Protein of unknown function (DUF789)
        4.6    7.1   8.8          9    6.1   0.2    2.7  2  PIP49_N         N-term cysteine-rich ER, FAM69


Domain annotation for each model (and alignments):
>> TBPIP  TBPIP/Hop2 winged helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.1   0.3   2.8e-21   8.2e-18       1      60 [.      71     130 ..      71     132 .. 0.97
   2 ?   -3.2   0.0       2.8   8.3e+03      16      29 ..     215     228 ..     215     232 .. 0.57

  Alignments for each domain:
  == domain 1  score: 64.1 bits;  conditional E-value: 2.8e-21
       TBPIP   1 eaeelvleylqeqnrPfsvqdvvanlqkklgKtavqkaLdeLvdegkiieKeyGKqkiYl 60 
                 ea++++ eyl++qnrP+s q v++n++++++K+ v+k Ld+L+ eg +++K  GKqk+++
  EFC36998.1  71 EAKSMIHEYLKNQNRPYSLQQVIDNMGGQIKKAMVTKCLDKLEGEGELVMKANGKQKMWF 130
                 7999*****************************************************998 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.8
       TBPIP  16 Pfsvqdvvanlqkk 29 
                 P+ ++d+va l+k 
  EFC36998.1 215 PQEKKDAVAGLEKY 228
                 55666666666553 PP

>> LZ3wCH  Leucine zipper with capping helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.8       1.4   4.3e+03       5      17 ..      50      62 ..      33      84 .. 0.58
   2 !   33.3   0.1   1.3e-11   3.8e-08       1      53 [.     213     268 ..     213     270 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.4
      LZ3wCH  5 ekkkatkkakeaa 17
                +k + +  ak+ a
  EFC36998.1 50 KKTATKGAAKKGA 62
                3333334444444 PP

  == domain 2  score: 33.3 bits;  conditional E-value: 1.3e-11
      LZ3wCH   1 etieekkkatkkakeaanrWtd...nifdikswikekfpkskkelneefgIetDeD 53 
                 ++++ekk+a++ ++++ ++W++    +++++     k +++ ++l ee+gI+tDe 
  EFC36998.1 213 VSPQEKKDAVAGLEKYLKEWRKrkeLAMTMLLGFADKAEMKLADLTEEIGIDTDES 268
                 689***************************************************96 PP

>> TFIIE_beta  TFIIE beta subunit core domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   8.7e-05      0.26       8      33 ..      76      99 ..      74     113 .. 0.76
   2 ?    2.8   0.6     0.047   1.4e+02      19      50 ..     149     177 ..     140     183 .. 0.77
   3 ?   -2.3   0.1       1.9   5.7e+03      25      25 ..     244     244 ..     225     272 .. 0.53

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.7e-05
  TFIIE_beta  8 iveylKkkdgplsleeIlsylslqld 33
                i eylK++++p sl+++ +++    +
  EFC36998.1 76 IHEYLKNQNRPYSLQQVIDNMGG--Q 99
                789****************9986..3 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.047
  TFIIE_beta  19 lsleeIlsylslqldlsdknwllleaLknnpk 50 
                 + + +I+++ls + ++s  n++l+  L++ +k
  EFC36998.1 149 IEIRDIQKELS-SYKIS--NQELTAELNKLNK 177
                 57899******.67774..5778888888776 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.9
  TFIIE_beta  25 l 25 
                 l
  EFC36998.1 244 L 244
                 1 PP

>> MCM_bind  Mini-chromosome maintenance replisome factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   9.9   0.00013       0.4     131     223 ..       4      97 ..       1     113 [. 0.73

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00013
    MCM_bind 131 KRsleeeeedeemdvsksekkeeissestkekeeeskssetekkskksasesklsaekllnfplpdekskaclVkvYdeed..elklNdvlevvG 223
                 KR++  e e+e+ d ++s++++++++e+ ++k +++k++et+kk+ ++++ +k  a+k  +  + +e+    +++ Y +++   + l +v++ +G
  EFC36998.1   4 KRKRAAEAEEESADETSSKEETQEEEET-EKKPKKTKKKETTKKAPAKKTATKGAAKKGAKPTIKNESEAKSMIHEYLKNQnrPYSLQQVIDNMG 97 
                 6666545555556666555555555433.566666777777777777777777778888889999999999999999877667899999998777 PP

>> DUF789  Protein of unknown function (DUF789)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   6.6   0.00086       2.6      86     164 ..      18      96 ..       3     113 .. 0.52

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00086
      DUF789  86 ksrrkseesesesveesss.ekssdsesekeslsekseseeessssdesessekeskgellfeYfE.sesPyeRepLadki 164
                 ++++k e++e+e++e  ++ +k++++e+ k++  +k++++  +++  + + +++++ ++++ eY+  +++Py+ ++++d +
  EFC36998.1  18 ETSSKEETQEEEETE--KKpKKTKKKETTKKAPAKKTATKGAAKKGAKPTIKNESEAKSMIHEYLKnQNRPYSLQQVIDNM 96 
                 111111111111111..11122222222333333333334343344667777889999******962578***99999877 PP

>> PIP49_N  N-term cysteine-rich ER, FAM69
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   3.4     0.021        62      99     141 ..      38      83 ..       9     101 .. 0.80
   2 ?    6.1   0.2     0.003         9     102     153 ..     156     207 ..     138     210 .. 0.76

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.021
     PIP49_N  99 cqleealkedleklswvrseasefdkPt...veefkemvkrylkak 141
                 ++ +e+ k+   k+  ++  a++  kPt   + e k m+++ylk++
  EFC36998.1  38 TKKKETTKKAPAKKTATKGAAKKGAKPTiknESEAKSMIHEYLKNQ 83 
                 4445777777788888888888999999999999*********986 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.003
     PIP49_N 102 eealkedleklswvrseasefdkPtveefkemvkrylkaklgeqlslekLvs 153
                 +e  +++ +++  + + +++ + Pt ee k+m+++  k+ lg + +le+L++
  EFC36998.1 156 KELSSYKISNQELTAELNKLNKAPTTEELKGMIEKERKDLLGRREKLERLEN 207
                 45555566666666666677788*************9999999999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (281 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2935  (0.163701); expected 358.6 (0.02)
Passed bias filter:                      816  (0.0455129); expected 358.6 (0.02)
Passed Vit filter:                       161  (0.00897987); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.82u 0.31s 00:00:01.12 Elapsed: 00:00:00.49
# Mc/sec: 1731.22
//
Query:       EFC36999.1  [L=356]
Description: prenyl/geranyl transferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.8e-63  208.6   6.9    1.1e-14   53.9   0.0    5.3  5  Prenyltrans      Prenyltransferase and squalene oxidase repea
     0.0041   16.3   0.0        7.2    5.6   0.0    3.6  5  SQHop_cyclase_N  Squalene-hopene cyclase N-terminal domain
     0.0068   15.5   0.0      0.017   14.3   0.0    1.7  1  SQHop_cyclase_C  Squalene-hopene cyclase C-terminal domain


Domain annotation for each model (and alignments):
>> Prenyltrans  Prenyltransferase and squalene oxidase repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.7   0.0   2.4e-09   1.4e-05       1      43 [.      64     107 ..      64     108 .. 0.95
   2 !   46.8   0.1     3e-16   1.8e-12       2      44 .]     119     161 ..     118     161 .. 0.97
   3 !   53.9   0.0   1.8e-18   1.1e-14       1      43 [.     180     222 ..     180     223 .. 0.97
   4 !   42.1   1.2   8.5e-15   5.1e-11       5      43 ..     232     270 ..     228     271 .. 0.91
   5 !   40.3   0.0   3.1e-14   1.9e-10       1      44 []     276     320 ..     276     320 .. 0.97

  Alignments for each domain:
  == domain 1  score: 24.7 bits;  conditional E-value: 2.4e-09
                  HHHHHHHHHHHHHSH.TTS-BBSSTTSSBBHHHHHHHHHHHHHC CS
  Prenyltrans   1 idvekavefLlscQn.edGGwggrpgsesdtyytywalaaLall 43 
                  +++e +++f++   + + GG++g p+++++  yt+ a++ L ll
   EFC36999.1  64 MNREHILQFIRDSYHaDVGGFAGAPNHDAHILYTLSAVQLLVLL 107
                  68999**********************************99886 PP

  == domain 2  score: 46.8 bits;  conditional E-value: 3e-16
                  HHHHHHHHHHHHSHTTS-BBSSTTSSBBHHHHHHHHHHHHHCT CS
  Prenyltrans   2 dvekavefLlscQnedGGwggrpgsesdtyytywalaaLallG 44 
                   +ek+ ef+ s Q edG+++g+ ++e dt+++y+al++LallG
   EFC36999.1 119 QIEKIGEFIGSLQKEDGSFSGDKWGEIDTRFSYCALNCLALLG 161
                  58****************************************8 PP

  == domain 3  score: 53.9 bits;  conditional E-value: 1.8e-18
                  HHHHHHHHHHHHHSHTTS-BBSSTTSSBBHHHHHHHHHHHHHC CS
  Prenyltrans   1 idvekavefLlscQnedGGwggrpgsesdtyytywalaaLall 43 
                  i+vek v+++lscQn dGG+g +pg es++++ ++++ aL+++
   EFC36999.1 180 INVEKTVDYVLSCQNFDGGFGVCPGAESHAGQIFTCVGALSIA 222
                  79***************************************97 PP

  == domain 4  score: 42.1 bits;  conditional E-value: 8.5e-15
                  HHHHHHHHHSHTTS-BBSSTTSSBBHHHHHHHHHHHHHC CS
  Prenyltrans   5 kavefLlscQnedGGwggrpgsesdtyytywalaaLall 43 
                  ++ ++L+ +Q+e GG++grp++ sd++y++w+l+aL ++
   EFC36999.1 232 TLSWWLCERQCENGGLNGRPEKLSDVCYSWWVLSALGIM 270
                  6779*******************************9666 PP

  == domain 5  score: 40.3 bits;  conditional E-value: 3.1e-14
                  HHHHHHHHHHHHHSH.TTS-BBSSTTSSBBHHHHHHHHHHHHHCT CS
  Prenyltrans   1 idvekavefLlscQn.edGGwggrpgsesdtyytywalaaLallG 44 
                  i+ ek+ +++++cQ+ e GG ++rp+  +d+++t++++ +L+llG
   EFC36999.1 276 INAEKLHDYICNCQDtEKGGISDRPNNMVDVFHTFFGIGGLSLLG 320
                  6889****************************************8 PP

>> SQHop_cyclase_N  Squalene-hopene cyclase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.16   9.7e+02      40      80 ..      59     100 ..      54     107 .. 0.83
   2 !    5.6   0.0    0.0012       7.4      33      88 ..     105     161 ..      96     168 .. 0.76
   3 !    5.6   0.0    0.0012       7.2      46      78 ..     181     216 ..     172     226 .. 0.79
   4 ?   -1.1   0.0      0.14   8.3e+02      47      76 ..     230     259 ..     212     270 .. 0.67
   5 ?   -1.7   0.0       0.2   1.2e+03      46      89 ..     277     321 ..     255     324 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.16
  SQHop_cyclase_N  40 geddeeeeekiakylrsqqred.GgWelypggpgdlsttvea 80 
                       e ++ ++e+i +++r++ ++d Gg++ +p++++++  t  a
       EFC36999.1  59 SESSKMNREHILQFIRDSYHADvGGFAGAPNHDAHILYTLSA 100
                      5667788999999**99999666******9999999998876 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0012
  SQHop_cyclase_N  33 illrefl.geddeeeeekiakylrsqqredGgWelypggpgdlsttveaYlALkllG 88 
                      +ll   + +  + e++eki +++ s q+edG+++  + g+ d  ++  a   L llG
       EFC36999.1 105 VLLTSNIeEFLTLEQIEKIGEFIGSLQKEDGSFSGDKWGEIDTRFSYCALNCLALLG 161
                      455555545667899******************987777777777766666666666 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0012
  SQHop_cyclase_N  46 eeekiakylrsqqredGgWelypggp...gdlsttv 78 
                      + ek++ y++s q+ dGg++++pg +   g+++t v
       EFC36999.1 181 NVEKTVDYVLSCQNFDGGFGVCPGAEshaGQIFTCV 216
                      678999****************98763335666666 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 0.14
  SQHop_cyclase_N  47 eekiakylrsqqredGgWelypggpgdlst 76 
                       + +  +l+++q e+Gg +  p++ +d+  
       EFC36999.1 230 HDTLSWWLCERQCENGGLNGRPEKLSDVCY 259
                      555666777777777777666666666554 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 0.2
  SQHop_cyclase_N  46 eeekiakylrsqqr.edGgWelypggpgdlsttveaYlALkllGd 89 
                      ++ek+  y+++ q  e+Gg +  p++  d++ t     +L llG+
       EFC36999.1 277 NAEKLHDYICNCQDtEKGGISDRPNNMVDVFHTFFGIGGLSLLGY 321
                      678999999999987889999999999999888877777777775 PP

>> SQHop_cyclase_C  Squalene-hopene cyclase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   2.8e-06     0.017     152     229 ..     111     202 ..      87     223 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.8e-06
                      HT--TTSHHHHHHHHHHHHHS-TTS----.SSB...SSHHHHHHHHHHHHHHTT..--......TTSHH..HHHHHHHHHTT--TTSSBB-- CS
  SQHop_cyclase_C 152 lgeeedsealkraveylkkeqepdGsWfG.rWG...vnyiyGtwsvlsalaavg..ed......leepv..irkavdWlksvqnedGGWGes 229
                      ++e  + e++++  e++ + q++dGs+ G +WG   + + y + ++l  l  ++  ++      +++++  ++k+vd++ s qn dGG+G +
       EFC36999.1 111 IEEFLTLEQIEKIGEFIGSLQKEDGSFSGdKWGeidTRFSYCALNCLALLGLLEtcSNyrgdkiNNKKYinVEKTVDYVLSCQNFDGGFGVC 202
                      44446778899999*************98679844456778877766544333211221222333344422689***************964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       425  (0.0237046); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 2321.77
//
Query:       EFC37000.1  [L=538]
Description: LRR repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-13   48.7  37.3    6.7e-05   23.2   4.2    8.0  7  LRR_4     Leucine Rich repeats (2 copies)
    1.1e-06   28.2  28.9      0.026   14.6   0.4    9.5  9  LRR_6     Leucine Rich repeat
     0.0091   16.4  31.2        4.4    8.2   1.6    8.7 11  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
        2.5    7.9  30.7        1.2    9.0   0.2    8.3  9  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.7   7.5e+03       2      20 ..     114     133 ..     113     137 .. 0.70
   2 !   23.2   4.2   1.5e-08   6.7e-05       1      44 []     146     197 ..     146     197 .. 0.89
   3 !    8.0   0.3   0.00091       4.1       2      32 ..     225     260 ..     224     272 .. 0.81
   4 ?    4.1   0.1     0.015        69       2      30 ..     303     331 ..     302     342 .. 0.80
   5 ?    3.6   3.7     0.021        95       2      30 ..     352     383 ..     351     409 .. 0.69
   6 !    6.3   0.6    0.0031        14       2      39 ..     404     443 ..     401     449 .. 0.58
   7 !   19.6   0.9     2e-07   0.00089       2      33 ..     456     493 ..     455     501 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.7
                 S--EEE--SS---.E-S-HH CS
       LRR_4   2 nLevLdLsnNqlt.diplle 20 
                 +L+ L +s ++l   i+ ++
  EFC37000.1 114 RLKCLTFSRCCLGdGIEVFR 133
                 68889999999996665554 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 1.5e-08
                 SS--EEE--SS---E-S-HH.......H.-TT--EEE-.-S-----GGGGXX CS
       LRR_4   1 pnLevLdLsnNqltdiplle.......k.lpnLkeLdLsgNnlitdldeLkn 44 
                 pnL++LdLs+N+l+d + +e       k + nL eL+L +N+ i++l++++n
  EFC37000.1 146 PNLTSLDLSSNHLSDENICEfcglideKfMCNLIELNLEFNSSIENLYPIAN 197
                 8**************99966667888999*********99*99999988875 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.00091
                 S--EEE--SS---E-S-...HH..H-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdipl...le..klpnLkeLdLsg 32 
                 +L+ L   ++++ + ++   l+  +++nL +L++s+
  EFC37000.1 225 SLTCLQMKHCNIEEGSFkqlLQneNMKNLSKLYISD 260
                 79999999*****988877644878*********87 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.015
                 S--EEE--SS---E-S-HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdL 30 
                 nL++L + +  +  i+ l +l +L++L +
  EFC37000.1 303 NLKILEFEGATVINIDQLHQLSKLETLAM 331
                 89999999999999***99*******977 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.021
                 S--EEE--SS.---E-S-..HH.H-TT--EEE- CS
       LRR_4   2 nLevLdLsnN.qltdipl..le.klpnLkeLdL 30 
                  L+ Ld+s N +ltd +   +  ++++L +L L
  EFC37000.1 352 TLKRLDISYNeKLTDHSIdlITsSFTKLSSL-L 383
                 6999****99999998877444449999998.5 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.0031
                 S--EEE--..SS---E-S-HH..H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLs..nNqltdiplle..klpnLkeLdLsgNnlitdl 39 
                 nL++L L+  +  ++  + ++  +++nLk L L +  + +d+
  EFC37000.1 404 NLTELELAgrDQSMS-YQYFNcsNMKNLKILKL-FSHQMGDI 443
                 344444442211233.33444757********9.44367777 PP

  == domain 7  score: 19.6 bits;  conditional E-value: 2e-07
                 S--EEE--SS---.E-S-.HH....H-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqlt.dipl.le....klpnLkeLdLsgN 33 
                 nLe+L+L+++++  +++  l+    +l++L++LdL++N
  EFC37000.1 456 NLEHLWLRHCNIAnEFSIlLAskesQLKKLRVLDLTEN 493
                 9************7777764488867*********998 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.037   1.7e+02       5      17 ..     115     127 ..     114     129 .. 0.91
   2 !   14.6   0.4   5.7e-06     0.026       3      18 ..     146     161 ..     146     161 .. 0.94
   3 ?    0.5   0.2      0.18   8.3e+02       3      15 ..     176     189 ..     175     191 .. 0.82
   4 ?    4.0   0.0     0.014        64       4      15 ..     225     236 ..     223     238 .. 0.92
   5 !    8.1   0.1   0.00069       3.1       4      17 ..     352     366 ..     351     370 .. 0.92
   6 ?   -0.5   0.0      0.38   1.7e+03       3      12 ..     403     412 ..     402     412 .. 0.84
   7 !    4.9   0.1     0.007        32       3      20 ..     428     445 ..     426     448 .. 0.89
   8 ?    3.7   0.3     0.018        81       3      18 ..     455     470 ..     454     470 .. 0.90
   9 ?    2.0   0.1     0.063   2.8e+02       3      13 ..     483     493 ..     481     496 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.037
       LRR_6   5 LteLdLsgNdIgD 17 
                 L+ L  s +++gD
  EFC37000.1 115 LKCLTFSRCCLGD 127
                 999*********9 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 5.7e-06
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 ++Lt+LdLs+N+++De
  EFC37000.1 146 PNLTSLDLSSNHLSDE 161
                 58*************8 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.18
       LRR_6   3 thLteLdLsgNd.I 15 
                 ++L eL+L +N  I
  EFC37000.1 176 CNLIELNLEFNSsI 189
                 7899******9655 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.014
       LRR_6   4 hLteLdLsgNdI 15 
                 +Lt L++++++I
  EFC37000.1 225 SLTCLQMKHCNI 236
                 7**********9 PP

  == domain 5  score: 8.1 bits;  conditional E-value: 0.00069
       LRR_6   4 hLteLdLsgNd.IgD 17 
                 +L+ Ld+s+N+ ++D
  EFC37000.1 352 TLKRLDISYNEkLTD 366
                 8*********99998 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 0.38
       LRR_6   3 thLteLdLsg 12 
                 ++LteL+L+g
  EFC37000.1 403 NNLTELELAG 412
                 69*****975 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.007
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                  +L+ L L ++++gD G+
  EFC37000.1 428 KNLKILKLFSHQMGDIGL 445
                 68*************998 PP

  == domain 8  score: 3.7 bits;  conditional E-value: 0.018
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 ++L++L L++++I +e
  EFC37000.1 455 SNLEHLWLRHCNIANE 470
                 79***********886 PP

  == domain 9  score: 2.0 bits;  conditional E-value: 0.063
       LRR_6   3 thLteLdLsgN 13 
                  +L+ LdL+ N
  EFC37000.1 483 KKLRVLDLTEN 493
                 58*******99 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.1      0.14   6.2e+02       1      14 [.     114     127 ..     114     138 .. 0.79
   2 !    8.2   1.6   0.00099       4.4       1      22 [.     147     168 ..     147     169 .. 0.82
   3 ?    3.8   0.5     0.027   1.2e+02       1      12 [.     177     188 ..     177     203 .. 0.85
   4 ?   -3.2   0.1         4   1.8e+04       2      13 ..     226     237 ..     225     245 .. 0.64
   5 ?   -2.6   0.0       3.6   1.6e+04       1       9 [.     252     260 ..     252     278 .. 0.69
   6 ?   -2.2   0.0       2.7   1.2e+04       6      12 ..     290     296 ..     288     311 .. 0.58
   7 !    5.8   0.0    0.0063        28       2      20 ..     353     376 ..     352     379 .. 0.68
   8 ?   -2.2   0.0       2.7   1.2e+04       1       8 [.     404     411 ..     404     427 .. 0.70
   9 ?   -3.7   0.0         4   1.8e+04       1       7 [.     429     435 ..     429     445 .. 0.75
  10 !    7.2   0.2    0.0022       9.9       1      12 [.     456     467 ..     456     479 .. 0.80
  11 !    5.3   0.0    0.0088        40       1      19 [.     484     502 ..     484     509 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.14
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L+ L  s+++l++
  EFC37000.1 114 RLKCLTFSRCCLGD 127
                 6999*******953 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00099
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++LdLs+n+l++  +  f++
  EFC37000.1 147 NLTSLDLSSNHLSDENICEFCG 168
                 8***********8777666666 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.027
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL +L+L+ n+ 
  EFC37000.1 177 NLIELNLEFNSS 188
                 89********96 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 4
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L + +++++
  EFC37000.1 226 LTCLQMKHCNIE 237
                 666777788763 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 3.6
       LRR_1   1 nLrhLdLsn 9  
                 nL +L++s+
  EFC37000.1 252 NLSKLYISD 260
                 677888764 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 2.7
       LRR_1   6 dLsnnpl 12 
                 d+s+n +
  EFC37000.1 290 DMSGNYF 296
                 6777765 PP

  == domain 7  score: 5.8 bits;  conditional E-value: 0.0063
       LRR_1   2 LrhLdLsnnpl.....lglppnsf 20 
                 L++Ld+s+n       ++l+ +sf
  EFC37000.1 353 LKRLDISYNEKltdhsIDLITSSF 376
                 9********954444456665555 PP

  == domain 8  score: -2.2 bits;  conditional E-value: 2.7
       LRR_1   1 nLrhLdLs 8  
                 nL++L L 
  EFC37000.1 404 NLTELELA 411
                 89999983 PP

  == domain 9  score: -3.7 bits;  conditional E-value: 4
       LRR_1   1 nLrhLdL 7  
                 nL+ L L
  EFC37000.1 429 NLKILKL 435
                 8999987 PP

  == domain 10  score: 7.2 bits;  conditional E-value: 0.0022
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+hL L+++++
  EFC37000.1 456 NLEHLWLRHCNI 467
                 8*********98 PP

  == domain 11  score: 5.3 bits;  conditional E-value: 0.0088
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +Lr+LdL+ np l +++ s
  EFC37000.1 484 KLRVLDLTENPDLVFSDTS 502
                 7*********975555444 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.2   0.00026       1.2      49      61 .]     146     158 ..     138     169 .. 0.66
   2 ?    0.8   0.2     0.091   4.1e+02      26      42 ..     177     194 ..     172     199 .. 0.74
   3 ?   -0.1   0.0      0.17   7.8e+02      44      61 .]     219     236 ..     207     244 .. 0.85
   4 ?   -1.8   0.0      0.63   2.8e+03      23      33 ..     249     259 ..     246     260 .. 0.60
   5 ?    1.5   0.1     0.057   2.5e+02      24      55 ..     301     330 ..     288     336 .. 0.70
   6 ?    4.9   0.3     0.005        22      25      39 ..     351     366 ..     324     390 .. 0.68
   7 ?   -1.1   0.0      0.37   1.7e+03      24      56 ..     402     410 ..     396     413 .. 0.58
   8 ?    1.4   1.7     0.061   2.7e+02      22      61 .]     425     467 ..     422     467 .. 0.75
   9 ?    3.7   1.1     0.012        54      22      35 ..     480     493 ..     455     500 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00026
                 -S-.EEE--SS-- CS
       LRR_8  49 psLrsLdLsgNrL 61 
                 p+L+sLdLs+N+L
  EFC37000.1 146 PNLTSLDLSSNHL 158
                 4555555555544 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.091
                 T--EEE--SS.---GGGG CS
       LRR_8  26 nLkvLdLsnN.llttlsp 42 
                 nL +L+L  N +++ l p
  EFC37000.1 177 NLIELNLEFNsSIENLYP 194
                 788888888877776665 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.17
                 GGTT--S-.EEE--SS-- CS
       LRR_8  44 afsgLpsLrsLdLsgNrL 61 
                 a+s ++sL+ L + ++++
  EFC37000.1 219 AISRMESLTCLQMKHCNI 236
                 678888999998888876 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 0.63
                 T-TT--EEE-- CS
       LRR_8  23 glsnLkvLdLs 33 
                 +++nL  L++s
  EFC37000.1 249 NMKNLSKLYIS 259
                 55666666655 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.057
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 +snLk+L+    +   +  + +++L++L+ L 
  EFC37000.1 301 FSNLKILEFEGATVINI--DQLHQLSKLETLA 330
                 67777777777744444..5888888888875 PP

  == domain 6  score: 4.9 bits;  conditional E-value: 0.005
                 TT--EEE--SS.---G CS
       LRR_8  25 snLkvLdLsnN.lltt 39 
                 + Lk Ld+s+N +lt 
  EFC37000.1 351 KTLKRLDISYNeKLTD 366
                 7899999999966664 PP

  == domain 7  score: -1.1 bits;  conditional E-value: 0.37
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 l+nL                        ++L L
  EFC37000.1 402 LNNL------------------------TELEL 410
                 4444........................44444 PP

  == domain 8  score: 1.4 bits;  conditional E-value: 0.061
                 TT-TT--EEE--SS---GGGGGGGTT...--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsg...LpsLrsLdLsgNrL 61 
                 ++++nLk+L+L + ++  +  g++     L++L++L L+++++
  EFC37000.1 425 SNMKNLKILKLFSHQMGDIGLGTLIKspfLSNLEHLWLRHCNI 467
                 5788888888888888888888877544477888888888876 PP

  == domain 9  score: 3.7 bits;  conditional E-value: 0.012
                 TT-TT--EEE--SS CS
       LRR_8  22 kglsnLkvLdLsnN 35 
                 ++l++L+vLdL++N
  EFC37000.1 480 SQLKKLRVLDLTEN 493
                 45666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       862  (0.0480785); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 3342.57
//
Query:       EFC37001.1  [L=335]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-32  112.4   0.9    4.7e-32  111.8   0.9    1.2  1  Peptidase_C1   Papain family cysteine protease
    9.6e-05   22.2   0.9    0.00017   21.4   0.9    1.4  1  Propeptide_C1  Peptidase family C1 propeptide
  ------ inclusion threshold ------
       0.14   12.4   0.0       0.24   11.7   0.0    1.3  1  MLANA          Protein melan-A


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.8   0.9   7.9e-36   4.7e-32       1     216 [.     114     327 ..     114     329 .. 0.85

  Alignments for each domain:
  == domain 1  score: 111.8 bits;  conditional E-value: 7.9e-36
                   STSCEETTTTTTG.SG---B-TSSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS--SSSC CS
  Peptidase_C1   1 lpesvDwrekgga.vtpvkdqgsCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdypYkake 95 
                   +p ++D+rek    v p ++  sC +  +f  v++++dr++i+t+ k +  lS+q +++C++   +gC+G + +n f+y++ +g +te++ pY++  
    EFC37001.1 114 IPLTFDVREKWPGcVFPANNIMSCSAVGTFTIVDSISDRFCIATGgKFKKLLSSQYMLECDR-DRQGCQGAVESNIFSYLEGNGTTTEECIPYSSGG 209
                   5889*****65445******************************97778889*********8.899****************************666 PP

                   S...SS-CGCGGGSE...EBEESEEEEEESSBHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEEEEEET.TEEEEEEE CS
  Peptidase_C1  96 g...gkCkkkkkkek...vakikgygkvkenseealkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivGygven.gkkyWivk 185
                   g    +C+++ k+ +    +kik+ +  + +  +++++ ++k+g +++ ++++         Gvy++ + +      + +i+G+gv + +++yWi+ 
    EFC37001.1 210 GevfDSCSTQCKDGSplkRYKIKKGSVGSLDIITDMQRDIMKYGSITAGFKMYF--------GVYQHLDQD-IGSFSSTKIIGWGVAEdQTPYWICV 297
                   6677666666433333444555555555555689**************999998........899997544.467899*******987699****** PP

                   -SBTTTSTBTTEEEEESSSSTGGGTTSSEEE CS
  Peptidase_C1 186 NsWgtdwgekGYiriargknnecgieseava 216
                      gtdwg++G +++ rg + ecgies+a +
    EFC37001.1 298 FEFGTDWGNNGMFWMLRGAD-ECGIESSAWS 327
                   ******************99.*****99865 PP

>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.9   2.8e-08   0.00017       2      23 ..      47      71 ..      46      82 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 2.8e-08
                   SHHHHHHHHHC.T-SEEE---..-S CS
  Propeptide_C1  2 SdefIdyiNsk.nttWkAgrN..Fd 23
                   S++ Id+iNs+ n+ WkA r+  F+
     EFC37001.1 47 SQDKIDKINSNpNSKWKATRYekFE 71
                   8888*****************9998 PP

>> MLANA  Protein melan-A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0     4e-05      0.24      27     103 ..      18      96 ..       7     103 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4e-05
       MLANA  27 Gigllvvv.LaillllgCwyykrrsGYkslrskslkvstlktlv.gegeleelakadsklalqefknfesvvpdapPaY 103
                  i+ lvvv L+++++++  ++   +G+++ ++k  k+++  ++  + +++e++++++ k  +++  +++  ++++p ++
  EFC37001.1  18 SIAFLVVVlLSTMIIMSTNFVILTNGFQMSQDKIDKINSNPNSKwKATRYEKFETQEWKDFVKNLPQIDDSLANSPSSF 96 
                 5777776626889999*****************9998887666515566777799999999999999999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       775  (0.0432261); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2122.79
//
Query:       EFC37002.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.9e-21   75.4  17.1      6e-21   75.2  17.1    1.1  1  PLA2G12          Group XII secretory phospholipase A2 precurs
    0.00026   21.6   8.8    0.00061   20.4   8.8    1.7  1  Phospholip_A2_3  Prokaryotic phospholipase A2


Domain annotation for each model (and alignments):
>> PLA2G12  Group XII secretory phospholipase A2 precursor (PLA2G12)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.2  17.1   6.7e-25     6e-21      48     182 .]       9     137 .]       3     137 .] 0.86

  Alignments for each domain:
  == domain 1  score: 75.2 bits;  conditional E-value: 6.7e-25
     PLA2G12  48 ll.ggedgvcqykcrdgkaPvprpgykvpepdGcgs..yllGlkldlgiPamtkccnqldicydtcgsekercdekfrlclekicsdlkkslglsskve 143
                 l+ gge+ vc  +c++g++ + + gyk    +Gcg    +  ++ ++g   +t+ccn++dicy  c+++ke+cd++f  cl+  c+  kk+     + +
  EFC37002.1   9 LFgGGENEVCGMTCPKGQSLIKKAGYKAI-FNGCGPsgEFNHISDKIG---FTNCCNEHDICYTDCSKSKEQCDSEFTECLNGHCKTKKKK-----EKD 98 
                 55267999******************975.799985113444455555...79********************************998874.....668 PP

     PLA2G12 144 acesvadllfdtvltlGckpyldsqraaclckeeekeel 182
                  c ++a+++  +v  +Gc +y +s ++ac ck+ +++el
  EFC37002.1  99 ECSTTATMFSWGVNAFGCDAYTKSIQEACECKSTKHDEL 137
                 9********************************999987 PP

>> Phospholip_A2_3  Prokaryotic phospholipase A2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   8.8   6.8e-08   0.00061      42     111 .]      53     115 ..      30     115 .. 0.86

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 6.8e-08
  Phospholip_A2_3  42 gfeFlesCqrhdFgYrnykaqkrfteanrkridknfkkdlkkqCkkveklkkkaCkaladvyyeavrafg 111
                      +  F++ C+ hd  Y + +       +++++ d++f + l+ +Ck+++k +k++C+++a+++ + v+afg
       EFC37002.1  53 KIGFTNCCNEHDICYTDCS-------KSKEQCDSEFTECLNGHCKTKKKKEKDECSTTATMFSWGVNAFG 115
                      45799**********9865.......567889**************99******************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       833  (0.046461); expected 358.6 (0.02)
Passed bias filter:                      214  (0.011936); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 844.69
//
Query:       EFC37003.1  [L=1154]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-17   64.0 140.6    0.00044   20.6   9.5   11.0 10  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   5.3   8.8e-08    0.0016       4      32 .]      66      94 ..      64      94 .. 0.88
   2 !   16.6  10.7   4.1e-07    0.0074       7      32 .]     109     133 ..     104     133 .. 0.92
   3 !   20.6   9.5   2.4e-08   0.00044       5      32 .]     164     190 ..     159     190 .. 0.88
   4 !   13.2   5.4   4.9e-06     0.087       5      32 .]     203     229 ..     200     229 .. 0.89
   5 !   13.7   8.8   3.4e-06     0.061       6      32 .]     249     273 ..     244     273 .. 0.87
   6 !   17.7   6.4   1.9e-07    0.0035       4      32 .]     284     317 ..     282     317 .. 0.89
   7 ?   -1.3   0.3      0.17     3e+03      22      32 .]     319     329 ..     319     329 .. 0.93
   8 !    6.8   8.8    0.0005       8.9       1      32 []     335     366 ..     335     366 .. 0.81
   9 ?    2.2   0.5     0.014   2.4e+02      22      32 .]     368     378 ..     368     378 .. 0.94
  10 ?    1.9  17.1     0.017     3e+02       1      26 [.     382     410 ..     381     428 .. 0.79

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 8.8e-08
       EGF_2  4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32
                s +++C+ghG C++   +C Cd+gy+  +C
  EFC37003.1 66 SkSDACSGHGACIDMD-VCNCDDGYYSVDC 94
                45689*******9888.9*********999 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 4.1e-07
       EGF_2   7 iCgghGtC.vnqcGqCdCdsgyqGktC 32 
                 +C+g+G+C +  +G C C+ g++G+ C
  EFC37003.1 109 ACSGRGSCgN--NGICTCQLGFYGDEC 133
                 6*******88..9************** PP

  == domain 3  score: 20.6 bits;  conditional E-value: 2.4e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + iC+g+G+C+ ++  C+C+ gy+G +C
  EFC37003.1 164 NQICSGNGKCIGTN-TCSCELGYSGSDC 190
                 78*********555.9************ PP

  == domain 4  score: 13.2 bits;  conditional E-value: 4.9e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  Cgg G+Cv+ + qC C+  y G  C
  EFC37003.1 203 EYVCGGVGQCVSMN-QCLCPHPYDGQEC 229
                 568********777.**********999 PP

  == domain 5  score: 13.7 bits;  conditional E-value: 3.4e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C g+G C  q G C+C+ g++G+ C
  EFC37003.1 249 RVCLGRGNCS-QSG-CECQLGFYGDAC 273
                 57*******9.667.************ PP

  == domain 6  score: 17.7 bits;  conditional E-value: 1.9e-07
       EGF_2   4 s.deiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                 + ++ C+ghG+C ++   C+C     +  ++G++C
  EFC37003.1 284 NdSLVCSGHGQCMDLD-MCECyssaqNGYWFGDDC 317
                 44789*******8788.9*******999******* PP

  == domain 7  score: -1.3 bits;  conditional E-value: 0.17
       EGF_2  22 dCdsgyqGktC 32 
                 +Cd+ ++G++C
  EFC37003.1 319 VCDPFHSGDNC 329
                 6********** PP

  == domain 8  score: 6.8 bits;  conditional E-value: 0.0005
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 Cs+ + +C++ G+C   +  C+C ++ y G +C
  EFC37003.1 335 CSN-EMTCNNLGICSPDNSSCSCsSDVYVGSYC 366
                 887.689*******866778***666666**99 PP

  == domain 9  score: 2.2 bits;  conditional E-value: 0.014
       EGF_2  22 dCdsgyqGktC 32 
                 +C+ +y+G++C
  EFC37003.1 368 ECKENYFGPSC 378
                 5********** PP

  == domain 10  score: 1.9 bits;  conditional E-value: 0.017
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdC.....dsg 26 
                 C + +++C+g+G C    G CdC        
  EFC37003.1 382 CVS-NSTCNGNGECS-RDGLCDCyhdldHGY 410
                 666.699*******7.368****77664444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      247  (0.0137766); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.79u 0.31s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 6793.60
//
Query:       EFC37004.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       850  (0.0474092); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.43
# Mc/sec: 1696.45
//
Query:       EFC37005.1  [L=239]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.3   0.1       0.22   11.4   0.1    1.5  1  F-box     F-box domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1   1.2e-05      0.22       7      32 ..      29      54 ..      23      62 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 1.2e-05
                -HHHHHHHHHTS-HHHHHHHCTT-HH CS
       F-box  7 PsevlrhILerLplsdllalrrVSkg 32
                 s+vl+++ ++L ++++l +r+V  +
  EFC37005.1 29 NSAVLLNVYSFLTFREVLTFRLVNQS 54
                689********************865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       809  (0.0451224); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1576.17
//
Query:       EFC37006.1  [L=287]
Description: hypothetical protein NAEGRDRAFT_82064 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0056   16.5   0.0       0.12   12.3   0.0    2.2  2  DUF5408   Family of unknown function (DUF5408)


Domain annotation for each model (and alignments):
>> DUF5408  Family of unknown function (DUF5408)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0     0.013   2.3e+02      22      49 ..       7      34 ..       2      40 .. 0.89
   2 !   12.3   0.0   6.6e-06      0.12      13      33 ..     104     124 ..      95     131 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.013
     DUF5408 22 itlllallslyvLlnqvsAtAalskeik 49
                + l ++ll   + l+q+  t a+ ke +
  EFC37006.1  7 ASLFFSLLGGLMTLDQIRRTLAIRKEWR 34
                678999999999***********99976 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 6.6e-06
     DUF5408  13 vkiALvCvvitlllallslyv 33 
                  + AL C ++tl++a++sl +
  EFC37006.1 104 FRYALGCSFATLIIATISLVM 124
                 5789**************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (287 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.23s 00:00:00.74 Elapsed: 00:00:00.43
# Mc/sec: 2025.43
//
Query:       EFC37007.1  [L=204]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-26   92.4   0.0    2.7e-26   92.1   0.0    1.1  1  Ras       Ras family
    1.4e-12   47.9   0.0    2.3e-12   47.2   0.0    1.4  1  Roc       Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.1   0.0     3e-30   2.7e-26       5     148 ..       1     165 [.       1     172 [. 0.93

  Alignments for each domain:
  == domain 1  score: 92.1 bits;  conditional E-value: 3e-30
                 EESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEET........TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHH CS
         Ras   5 vGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievd........gkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwv 94 
                 +G + vGKt+ll+r   ++F+++y++T+ +d+++k+ +v+        + + ++  wDTAG e++++lr+l+y +++ + + y+i++ +s++ +  +++
  EFC37007.1   1 MGATFVGKTCLLNRVGYHSFPQDYTPTV-FDSFVKTEHVQcivdgietQADFSVAYWDTAGGEDYDRLRPLSYPQTNLFTMNYAINDFSSLKYLVeHLM 98 
                 58999***********************.***999999988999997777788888**********************************997543888 PP

                 HHHHHHSTTTSEEEEEEETTTGGG.............G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCT CS
         Ras  95 eeikrvaeenvpivLvGnKvDlee.............kravsteegeelakelg.lkfletSAktnen 148
                  e +  a+ + ++v+v +K Dl++             ++ +s+eeg e+ k +g + f+etSAkt e+
  EFC37007.1  99 WECTLGAP-TATFVVVSTKNDLKDslywnslfysttvDEPISKEEGIEFTKAIGaVSFIETSAKTGEG 165
                 88888888.59*******************************************9*********9876 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.2   0.0   2.6e-16   2.3e-12       6     119 ..       2     118 ..       1     119 [. 0.82

  Alignments for each domain:
  == domain 1  score: 47.2 bits;  conditional E-value: 2.6e-16
                 SSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGG..SGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHHHHHHH CS
         Roc   6 GdsgvGKtsllkrfvedkfsekekstigvdfltkevtk..ikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssenlkeWlkel 102
                 G + vGKt+ll+r+  ++f +++++t+  +f+++e ++  ++g+e+   + +++++ WDtaG e+++ l+pl + + +l+ + y  +++++lk+ +++l
  EFC37007.1   2 GATFVGKTCLLNRVGYHSFPQDYTPTVFDSFVKTEHVQciVDGIET---QADFSVAYWDTAGGEDYDRLRPLSYPQTNLFTMNYAINDFSSLKYLVEHL 97 
                 8899**************************9987765511345443...457999********************************999999888877 PP

                 HHH....CSSS-EEEEEE-TT CS
         Roc 103 kkv....agkspvilvgnkiD 119
                   +    a+++ +++v +k D
  EFC37007.1  98 MWEctlgAPTATFVVVSTKND 118
                 655111145667888999988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (204 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       397  (0.0221429); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1301.89
//
Query:       EFC37008.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.08   13.3   0.1       0.24   11.8   0.1    1.7  1  DUF2805   Protein of unknown function (DUF2805)


Domain annotation for each model (and alignments):
>> DUF2805  Protein of unknown function (DUF2805)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   1.3e-05      0.24      25      50 ..     226     251 ..     222     256 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.3e-05
     DUF2805  25 ekeviklMrkelkassFklWrkrvsg 50 
                  ++v++l++++ ++s + +Wrk+ s+
  EFC37008.1 226 PSKVMELLKSHFRPSPHSMWRKKSSE 251
                 679*******************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2212.53
//
Query:       EFC37009.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      277  (0.0154498); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.27s 00:00:00.71 Elapsed: 00:00:00.46
# Mc/sec: 683.27
//
Query:       EFC37010.1  [L=342]
Description: calponin homology domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-22   79.9   0.0    2.3e-22   79.3   0.0    1.4  1  CH               Calponin homology (CH) domain
    6.1e-08   32.2   4.0    1.1e-07   31.4   4.0    1.4  1  SHOCT            Short C-terminal domain
  ------ inclusion threshold ------
       0.52   10.4   3.9         48    4.1   0.0    3.9  4  SBBP             Beta-propeller repeat


Domain annotation for each model (and alignments):
>> CH  Calponin homology (CH) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.3   0.0   3.8e-26   2.3e-22       2     108 ..      38     142 ..      37     143 .. 0.92

  Alignments for each domain:
  == domain 1  score: 79.3 bits;  conditional E-value: 3.8e-26
                 HHHHHHHHHHHHHHTTSTTSSTTSCHHHHHTTSHHHHHHHHHHSTTTSSGGGSTTTHHHHHHHHHHHHHHHHHHTTCHTTSS.-HHHHHTTSHH.HHHH CS
          CH   2 eqkkellrWinshleeagpkvkvedfeedlrDGvlLckLlnklapglvdkkklnksefkkleNinlaldvaekklgvpkvli.eaedlvegknk.svlt 98 
                 + +ke+++Wi+++++ + ++   +df+e+l+DGvlLckL+nk++pg v+  +  k +f ++eNi ++l++a+ +lg+++ ++  ++dl+egkn  +v+ 
  EFC37010.1  38 QKEKEVRQWIEAVTGTKFSS---NDFQESLKDGVLLCKLANKIKPGIVKTINSGKMPFMCMENIGYFLKAAA-ELGLDTHNTfMSVDLYEGKNIpLVIM 132
                 5799**********886544...7***********************999999888*************888.************************** PP

                 HHHHHHHHHH CS
          CH  99 llaqLfrafq 108
                  l+++ ++ q
  EFC37010.1 133 ALYSFGSVVQ 142
                 ***9988765 PP

>> SHOCT  Short C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   4.0   1.8e-11   1.1e-07       1      28 []     313     340 ..     313     340 .. 0.98

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 1.8e-11
       SHOCT   1 daLekLkeLyarGeIteEEFeakKakLL 28 
                 d+LekL  L+++G+Ite EF+ kK++LL
  EFC37010.1 313 DELEKLGNLRDKGIITEREFQLKKKQLL 340
                 89*************************8 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.37   2.2e+03       4      18 ..     178     193 ..     178     194 .. 0.76
   2 ?    1.4   0.1     0.053   3.2e+02       3      18 ..     210     225 ..     210     226 .. 0.93
   3 ?    4.1   0.0     0.008        48       2      19 ..     241     258 ..     240     259 .. 0.92
   4 ?    3.2   0.1     0.015        92       2      18 ..     273     289 ..     272     290 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.37
        SBBP   4 tqlG.gpgastygngI 18 
                 +q+G ++ ++++g++I
  EFC37010.1 178 QQFGaASVKHDTGRSI 193
                 6889666678899998 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.053
        SBBP   3 stqlGgpgastygngI 18 
                 s+q Gg+ ++++g++I
  EFC37010.1 210 SQQTGGSVKHDTGRSI 225
                 699************9 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.008
        SBBP   2 WstqlGgpgastygngIa 19 
                 +s+q Gg+ ++++g++I 
  EFC37010.1 241 FSQQTGGSVKHDTGRSIS 258
                 89**************95 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.015
        SBBP   2 WstqlGgpgastygngI 18 
                 +s+q Gg+ ++++g++I
  EFC37010.1 273 FSQQTGGSIKHDTGRSI 289
                 89**************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2076.51
//
Query:       EFC37011.1  [L=302]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.7e-51  173.3   0.1    7.6e-51  172.9   0.1    1.1  1  NmrA             NmrA-like family
    1.7e-17   63.9   0.0    2.8e-17   63.2   0.0    1.3  1  NAD_binding_10   NAD(P)H-binding
    7.2e-09   35.5   0.2    2.2e-08   33.9   0.2    1.8  2  Epimerase        NAD dependent epimerase/dehydratase family
    2.6e-06   26.6   0.1    3.7e-06   26.2   0.1    1.2  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
    2.1e-05   24.8   0.1      4e-05   23.8   0.1    1.5  1  TrkA_N           TrkA-N domain
    8.1e-05   22.9   0.2    0.00031   21.0   0.1    1.9  2  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
    0.00017   21.5   0.5    0.00034   20.6   0.2    1.6  2  KR               KR domain
     0.0021   18.1   1.4      0.016   15.3   0.2    2.4  2  DapB_N           Dihydrodipicolinate reductase, N-terminus
  ------ inclusion threshold ------
      0.017   15.7   0.3       0.04   14.5   0.3    1.6  1  F420_oxidored    NADP oxidoreductase coenzyme F420-dependent
      0.044   13.8   0.2      0.093   12.8   0.2    1.5  1  Shikimate_DH     Shikimate / quinate 5-dehydrogenase
      0.061   13.8   0.2       0.15   12.5   0.1    1.7  1  Semialdhyde_dh   Semialdehyde dehydrogenase, NAD binding doma


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  172.9   0.1   4.7e-54   7.6e-51       1     232 [.       5     240 ..       5     241 .. 0.95

  Alignments for each domain:
  == domain 1  score: 172.9 bits;  conditional E-value: 4.7e-54
                 EEESSTTSHHHHHHHHHHHH.HT-EEEEEES-S-SHHHHHHHHSTTEEEES-TT-HHHHHHHHTT-SEEEE---GG.......S-HHHHHHHHHHHHHH CS
        NmrA   1 IlviGaTGrqGksvvrallk.aghkvralvRdtkselakslkeaGvelvkgdlddkeslvealkgvdvvfsvtgfy.......skeiedgkklvdAake 91 
                 I+viGaTG+qG+sv+++l k  ++k r ++Rd++s +ak+l+e+Gve+v+ ++ +ke l+ea+kg+++vf vt+         +ke+ +g +lv+Aa++
  EFC37011.1   5 IVVIGATGKQGGSVIKHLQKqGNWKLRGITRDSNSARAKELAEQGVEIVSCNMSNKEALAEAFKGAYGVFGVTTPGrfgsvdhEKELTEGLNLVEAAVK 103
                 89****************996779*************************************************96689999****************** PP

                 HS-SEEEEEE---GG.GT.SSS---TTTHHHHHHHHHHHHCTS-E.EEEEE-EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE.-HHHHHHH CS
        NmrA  92 aGvkhfiySslgddndrsnaeepavphfdsKaeieeyvralgipy.tfvyagffmenflsllaqlkvgdtappedkvtllgpgnpkavll.daeeDiGa 188
                   v+hf++Ssl d  ++s +++ +vphf +K ++e+  r+  ip+ tfvy++ff+ n+ +++       +++++ ++ + +  n++ +l+ + ++D G 
  EFC37011.1 104 NNVQHFVFSSLDDVTKASGGKI-SVPHFTNKNKVEQEARKTNIPFkTFVYPPFFADNLPGMMFR-----LNEDRASAMIFAGVNTDRKLPvFGVDDLGI 196
                 ***************9998888.*********************65**************9999.....8888889999999**9999999******** PP

                 HHHHHHHHHHHHTTEEEEE-SEEE-HHHHHHHHHHHHTS-EEEE CS
        NmrA 189 fvikilkdprklkgkriklagntlsgneivelfekkigktvkYt 232
                 +v +++k+p++++g+ +  ag+++s++e++++ + +++ + +Y+
  EFC37011.1 197 VVSEVFKHPENYNGRKLLTAGDYVSLKEMADICTTVLNVPTQYV 240
                 ********************************999999888886 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.2   0.0   1.7e-20   2.8e-17       1     150 [.       9     161 ..       9     176 .. 0.82

  Alignments for each domain:
  == domain 1  score: 63.2 bits;  conditional E-value: 1.7e-20
                     TTTSHHHHHHHHHHHHC-T-EEEEEETT..HHHCHHHHCTTTCEEEE--TT-CCHHHHHHTT-SEEEES-..--TCC.....HHHH....HHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRn..peklaeleaeeglevvegdvtdvedlaealkgadaVvsal..ggggk.....deeg....akniv 82 
                     GAtGk G  ++k+l ++g+++++ ++R+  +++++el+ e+g+e+v+ +++++e+laea+kga  V+  +  g  +      +         n+v
      EFC37011.1   9 GATGKQGGSVIKHLQKQGNWKLRGITRDsnSARAKELA-EQGVEIVSCNMSNKEALAEAFKGAYGVFGVTtpG--RFgsvdhE--KelteGLNLV 98 
                     9**************************93345667775.7**************************9999552..33335333..244668999* PP

                     HHHHHCT--EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEE.EEEEE-CEE-S.T CS
  NAD_binding_10  83 daakeagvkRfvlvsaigvgdevpgefgewnkellkaylaakraaeellrasgldw.TivrpggLtde.p 150
                     +aa +++v++fv+ s  +v++ + g+ +        + +  k++ e++ r++++ + T+v p+++ d+ p
      EFC37011.1  99 EAAVKNNVQHFVFSSLDDVTKASGGKISV-------PHFTNKNKVEQEARKTNIPFkTFVYPPFFADNlP 161
                     ***************99999765555543.......56789**************88*******999834 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   0.2   1.3e-11   2.2e-08       1     114 [.       5     113 ..       5     134 .. 0.87
   2 ?   -3.9   0.0       4.5   7.3e+03     211     228 ..     218     235 ..     217     239 .. 0.84

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 1.3e-11
                 EEEETTTSHHHHHHHHHHHHCT.SEEEEEES-STTTTCHHCHHC..EEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHHHSHHHHHHHHTHHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekg.yevigldrlssasntarledl..elveldltdrsalerlfkeeqpdavihlAavggvaassedpadfieknlqgtl 96 
                 i+V+GatG  G  ++k+l+++g +++ g++r+s++ + ++l++   e+v +++ +++al+++fk  ++  v+ +    g   s++      ek l   l
  EFC37011.1   5 IVVIGATGKQGGSVIKHLQKQGnWKLRGITRDSNSARAKELAEQgvEIVSCNMSNKEALAEAFK--GAYGVFGV-TTPGRFGSVD-----HEKELTEGL 95 
                 89********************999*******99999999998899******************..77777777.2333333333.....4577888** PP

                 HHHHHHHHHTCTEEEEEE CS
   Epimerase  97 nlleaarkagvkrllfls 114
                 nl+eaa k++v+ ++f s
  EFC37011.1  96 NLVEAAVKNNVQHFVFSS 113
                 ****************98 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 4.5
                 EEEEHHHHHHHHHHHHHH CS
   Epimerase 211 dflyveDvaeaillvleh 228
                 d++  +++a+++ +vl+ 
  EFC37011.1 218 DYVSLKEMADICTTVLNV 235
                 788899999999999975 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.1   2.2e-09   3.7e-06       1     120 [.       6     118 ..       6     142 .. 0.87

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 2.2e-09
   3Beta_HSD   1 vvtGgaGFlGralvkeLvrleelkevrvlDlrespelleelskvnvkkviegDvtdkdkleealegvdvvihlaslvdvagkltedeimkvnvkGTrnv 99 
                 vv+G++G  G +++k+L + ++ +++r +  + ++   +el + +v+ ++ + + +k+ l ea +g++ v+ + +     ++++e+e+ +       n+
  EFC37011.1   6 VVIGATGKQGGSVIKHLQKQGN-WKLRGITRDSNSARAKELAEQGVE-IVSCNMSNKEALAEAFKGAYGVFGVTTPGRFGSVDHEKELTE-----GLNL 97 
                 8********************7.******999999988899999998.*************************99999998888886554.....479* PP

   3Beta_HSD 100 leacvkagvrvlvYtSsaevv 120
                 +ea+vk++v+ +v+ S  +v 
  EFC37011.1  98 VEAAVKNNVQHFVFSSLDDVT 118
                 **************8866664 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.1   2.5e-08     4e-05       1      61 [.       5      69 ..       5     110 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 2.5e-08
                EEEES.-SHHHHHHHHHHHH.TTEEEEEEESSH..HHHHHHHHTTSEEEES-TTSHHHHHHTTGG CS
      TrkA_N  1 iiiiG.lGrvGrslaeeLse.ggkdvvvidkde..erveelreeglevvvgdatdeevLeeagie 61
                i++iG  G+ G s+++ L++ g+++  +i +d   +r++el+e+g+e+v  + +++e+L+ea   
  EFC37011.1  5 IVVIGaTGKQGGSVIKHLQKqGNWKLRGITRDSnsARAKELAEQGVEIVSCNMSNKEALAEAFKG 69
                68888679************88899****87774477***********************99555 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.1   1.9e-07   0.00031       1      70 [.       5      70 ..       5      85 .. 0.85
   2 ?   -1.5   0.0       1.7   2.7e+03      54      84 ..     214     243 ..     211     254 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.9e-07
                     EEEE--.SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHHTTTCEEEEE--TTTHHHHHHHHHTTS CS
  Sacchrp_dh_NADP  1 vliiGa.GsvGqavaellarhfdvdaeitvadrskeklealaakalgvrfeaialdaenyeavLaallkeg 70
                     +++iGa G+ G +v++ l++++++  ++  ++r+ ++++a   +++++ +e+++++ +n+ea La++ k++
       EFC37011.1  5 IVVIGAtGKQGGSVIKHLQKQGNW--KLRGITRDSNSARAK--ELAEQGVEIVSCNMSNKEA-LAEAFKGA 70
                     89*********************9..777777777774444..457899*************.99999987 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.7
                      --TTTHHHHHHHHHTTSSEEEE-SSGGGHHH CS
  Sacchrp_dh_NADP  54 ldaenyeavLaallkegdlvvnlsppissld 84 
                      l+a +y + L+++    + v+n+ +++ ++d
       EFC37011.1 214 LTAGDYVS-LKEMADICTTVLNVPTQYVAMD 243
                      67888888.9999888899999888887765 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.2   2.1e-07   0.00034       4      74 ..       6      69 ..       4      77 .. 0.87
   2 ?   -2.5   0.0       2.6   4.3e+03     117     137 ..      95     114 ..      92     122 .. 0.73

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 2.1e-07
                EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHH CS
          KR  4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdaveallee 74
                +++G++G+ G +++++l ++g+ +l  ++R+     +++a+ +el+++g+e+  v++  s+k+a++++++ 
  EFC37011.1  6 VVIGATGKQGGSVIKHLQKQGNWKLRGITRD-----SNSARAKELAEQGVEI--VSCNMSNKEALAEAFKG 69
                79*****************************.....34456789***99776..78899******999876 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2.6
                 HHHHHHTTTS--SEEEEEEEH CS
          KR 117 wnLhelledesldffvlfSSi 137
                  nL e+  ++++ +fv fSS+
  EFC37011.1  95 LNLVEAAVKNNVQHFV-FSSL 114
                 5788888889999998.4555 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.2   9.8e-06     0.016       3      65 ..       5      67 ..       3      82 .. 0.73
   2 ?    1.2   0.1      0.23   3.7e+02      31      67 ..      84     120 ..      80     144 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 9.8e-06
                EEEETTTSHHHHHHHHHHHHSTTEEEEEEEETTCSTTTTTBHHHHSSSS--S-BEBSSHHHHH CS
      DapB_N  3 vavvGasGrmGkevvkaveeaedlelvaavdrkeselegkdagellglgklgvavtddleevl 65
                ++v+Ga+G+ G +v+k ++++ + +l +    ++s+  ++ a + +++ ++++  ++ l+e++
  EFC37011.1  5 IVVIGATGKQGGSVIKHLQKQGNWKLRGITRDSNSARAKELAEQGVEIVSCNMSNKEALAEAF 67
                89*************************999888854444444444555555555555555555 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.23
                 EEETTCSTTTTTBHHHHSSSS--S-BEBSSHHHHHHH CS
      DapB_N  31 avdrkeselegkdagellglgklgvavtddleevlek 67 
                  vd++++ +eg ++ e++ +++++ +v+++l++v+++
  EFC37011.1  84 SVDHEKELTEGLNLVEAAVKNNVQHFVFSSLDDVTKA 120
                 5777777788888888888889999999999998877 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.3   2.5e-05      0.04       2      62 ..       5      66 ..       4      68 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 2.5e-05
                   EEEE.TTSHHHHHHHHHHHHTTS.-GGCEEEEEESSCCCHHHHHHH.HC-EEECECHHHHHHH- CS
  F420_oxidored  2 igii.GaGnmgealasgllaaga.qpheivvansrnpekaeelaee.lgvkvtavdneeaaeea 62
                   i +i ++G++g ++++ l+++g  + + i+   ++n  +a+elae+ +++  + ++n+ea++ea
     EFC37011.1  5 IVVIgATGKQGGSVIKHLQKQGNwKLRGIT--RDSNSARAKELAEQgVEIVSCNMSNKEALAEA 66
                   6789779***************87777777..58899999999965155777889999999875 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.2   5.7e-05     0.093      13      70 ..       3      61 ..       1      70 [. 0.80

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 5.7e-05
                  -EEEEES-.SHHHHHHHHHHHCCT-CEEEEEES..SHHHHHHHHHHHT.ET-EEEEGCGHH CS
  Shikimate_DH 13 kkvlliGa.GemaelvakhLlakgvkkvvvaNR..tlerakelaeelkgeeiealkleelk 70
                  k +++iGa G+ +  v+khL ++g  k+  + R  + +rakelae+   +ei  +++++ +
    EFC37011.1  3 KLIVVIGAtGKQGGSVIKHLQKQGNWKLRGITRdsNSARAKELAEQG--VEIVSCNMSNKE 61
                  5689***88***************999999999334679999*9986..667777777655 PP

>> Semialdhyde_dh  Semialdehyde dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   9.2e-05      0.15       2      64 ..       5      67 ..       4     101 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 9.2e-05
                    EEEETTTSHHHHHHHHHHHCTSSEEEEEEEESTTTT.TSBHHHHSGGGTTTECEBEEEGGGGGC CS
  Semialdhyde_dh  2 vaivGatGyvGqellrlLeehpevelvvllsssrsa.Gkklaeavkaleegkdlkvedvdeeel 64
                    + ++GatG  G  +++ L+++ +++l  ++  s+sa  k+lae  +     ++++ +++ +e++
      EFC37011.1  5 IVVIGATGKQGGSVIKHLQKQGNWKLRGITRDSNSArAKELAEQ-GVEIVSCNMSNKEALAEAF 67
                    679*************************9999995414444444.3344444555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 1926.41
//
Query:       EFC37012.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00073   19.9  20.1       0.05   14.0   4.7    2.5  2  EGF_2            EGF-like domain
  ------ inclusion threshold ------
        2.4    8.5  20.1         13    6.1   8.5    2.4  2  Metallothi_Euk2  Eukaryotic metallothionein


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   4.7   5.5e-06      0.05       5      25 ..      41      60 ..      37      69 .. 0.80
   2 !   11.5   7.5   3.3e-05      0.29       4      25 ..      92     112 ..      88     119 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 5.5e-06
       EGF_2  5 deiCgghGtCvnqcGqCdCds 25
                +  C+ +G+Cv  + +C+C++
  EFC37012.1 41 KGVCSRRGKCVGNN-KCECFA 60
                678********444.9***74 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 3.3e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdCds 25 
                 +++ C g+G Cv  + +C+C +
  EFC37012.1  92 DKNVCYGRGRCVGNN-KCKCYN 112
                 4789********444.9***54 PP

>> Metallothi_Euk2  Eukaryotic metallothionein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   8.4    0.0095        85      25      48 ..      48      73 ..      32      96 .. 0.67
   2 ?    6.1   8.5    0.0015        13      26      45 ..     101     120 ..      85     127 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.0095
  Metallothi_Euk2 25 kscvgnkkckcdh..nsessqckscg 48
                      +cvgn+kc c     se  +c++ g
       EFC37012.1 48 GKCVGNNKCECFApeLSEPKRCRATG 73
                     47*********641145666777666 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0015
  Metallothi_Euk2  26 scvgnkkckcdhnsessqck 45 
                       cvgn+kckc    +s+ c 
       EFC37012.1 101 RCVGNNKCKCYNRDKSAACA 120
                      6***********99**9996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1188  (0.0662614); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.35u 0.24s 00:00:00.59 Elapsed: 00:00:00.40
# Mc/sec: 1195.75
//
Query:       EFC37013.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.3e-08   32.6   0.3    4.6e-08   32.1   0.3    1.1  1  Cpn60_TCP1  TCP-1/cpn60 chaperonin family
     0.0019   18.5   2.9      0.024   15.0   3.0    2.5  3  YgbA_NO     Nitrous oxide-stimulated promoter


Domain annotation for each model (and alignments):
>> Cpn60_TCP1  TCP-1/cpn60 chaperonin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.3   5.2e-12   4.6e-08     186     330 ..      80     221 ..      66     243 .. 0.89

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 5.2e-12
                 ESS--SSTTSSCEEECEEEEEESS-BS--HHCCHHHCCCCSCCHHHHHHHHHHHHHHHHHHHHHHTTECEEEESS-B-HHHHHHHHHCT-EEE-S--HH CS
  Cpn60_TCP1 186 ldkgvlspdmpkklenakvllldvsLeiektetkttvvlsdaeeleklekaeekqleellekiiksgvnvvvcqkgiddlalhflakngilalrrvkkk 284
                 ++++ +s++  k++e++ v+l+d+++ + ++    ++  sd + +++  +++++    + + i ++g++ v++  + ++l+ +++ k gi+  + ++++
  EFC37013.1  80 VNRNKSSNTKRKRIEKVSVALIDFKFPTLTS---LEIYGSDYTAIDAAIREQRRNNITIGKIINEMGCKMVISLFENEQLVSKLFDKFGIIYQEGISRQ 175
                 477777788899**************99999...999************************************************************** PP

                 HHHHHHHHHT--EBSCGGGGGCGC-EEEEEEEECCETTCCEEEEEC CS
  Cpn60_TCP1 285 dlerlakatGatavssledltpeelGtakkveeekigsekttiiee 330
                 dle+la++++++++s+ ++l + + G a++ e ++ ++  + iie+
  EFC37013.1 176 DLEKLANVLNGEIISDYQHLRSFKCGFADSAELTEDNNIVISIIEN 221
                 *******************************555544444444554 PP

>> YgbA_NO  Nitrous oxide-stimulated promoter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0      0.76   6.8e+03      54      88 ..      72     106 ..      67     113 .. 0.66
   2 ?   -0.4   0.0      0.16   1.5e+03      34      53 ..     187     206 ..     154     214 .. 0.75
   3 !   15.0   3.0   2.6e-06     0.024      28      77 ..     363     414 ..     351     418 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.76
     YgbA_NO  54 ttCskCkvHCYkpemrekirevmryagPrmllkhP 88 
                 t+C++ ++   +++   k +++ + +   + +k P
  EFC37013.1  72 TFCNQIEIVNRNKSSNTKRKRIEKVSVALIDFKFP 106
                 67888887777776666666666666555555555 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.16
     YgbA_NO  34 kelleyaekrldkCpfgeek 53 
                 + + +y + r+ kC f ++ 
  EFC37013.1 187 EIISDYQHLRSFKCGFADSA 206
                 56789*********999875 PP

  == domain 3  score: 15.0 bits;  conditional E-value: 2.6e-06
     YgbA_NO  28 elceeckelleyae..krldkCpfgeekttCskCkvHCYkpemrekirevmr 77 
                 +  e+c+ + e  +  + l++  + +ek +C+kCk H ++ e+ ++ +++++
  EFC37013.1 363 SFIENCEWIFECPMkySELERIDYADEKRFCTKCKKHVFRAETMQNFKQIIQ 414
                 5556666666544311468899************************999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2829.47
//
Query:       EFC37014.1  [L=1162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.5e-13   48.9   0.1    4.5e-11   42.8   0.0    2.9  2  BK_channel_a  Calcium-activated BK potassium channel alpha su
    7.9e-13   48.2   7.7    7.9e-13   48.2   7.7    2.0  2  Ion_trans_2   Ion channel
    6.4e-08   32.9   0.0    3.1e-05   24.2   0.1    2.9  2  TrkA_N        TrkA-N domain
    1.4e-05   24.5   9.4      3e-05   23.4   9.4    1.4  1  Ion_trans     Ion transport protein


Domain annotation for each model (and alignments):
>> BK_channel_a  Calcium-activated BK potassium channel alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.8   0.0     1e-14   4.5e-11       8      93 ..     446     557 ..     439     562 .. 0.94
   2 ?    2.9   0.0     0.028   1.3e+02      63      98 .]    1011    1045 ..     976    1045 .. 0.81

  Alignments for each domain:
  == domain 1  score: 42.8 bits;  conditional E-value: 1e-14
  BK_channel_a   8 addvicleelKlglLAqsclcpGistllanLissasikee..........................stkseewlkeYlrgagneiytiklskkfegm 78 
                   a+ vic e +  +lL+ s  + G++++l nL+s a+ + e                           +++ +w+ eY +g++ eiy++k+sk+f+g 
    EFC37014.1 446 AKVVICNESFCTKLLSGSSSSGGLCSFLFNLLSGADVDIEmdkipkglltgdhhkfdmqsgknttsIENDIKWIVEYSEGLNCEIYRVKFSKAFVGS 542
                   6789********************************99999**********************99888999************************** PP

  BK_channel_a  79 tfteaaalifeelgv 93 
                    f +aa+++ +++++
    EFC37014.1 543 LFVDAARTLLKKCEI 557
                   ***********9986 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.028
  BK_channel_a   63 gneiytiklskkfegmtfteaaalifeelgvlLiai 98  
                    +  i+++ +++ f+++ ++e+++ +fe+  ++L+++
    EFC37014.1 1011 QSIIFEVPVPTVFVNLPVSELVDACFEKD-LILLGV 1045
                    55689999999****************99.999987 PP

>> Ion_trans_2  Ion channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.6       2.9   1.3e+04      59      71 ..     173     185 ..     168     187 .. 0.73
   2 !   48.2   7.7   1.8e-16   7.9e-13       2      77 ..     220     297 ..     219     299 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.9
                  HHHHHHHHHHHHH CS
  Ion_trans_2  59 illGlalfalfla 71 
                  +++Gl++++lf+a
   EFC37014.1 173 LFIGLFFVGLFFA 185
                  6788888888876 PP

  == domain 2  score: 48.2 bits;  conditional E-value: 1.8e-16
                  HHHHTCHHHHHHHHT......T---HHHHHHHHHHHHTTS----SSTT-----HHHHHHHHHHHHHHHHHHHHHHHHH CS
  Ion_trans_2   2 vlllvlifgaviysl..eegwekwsfldalYfsfvtltTiGYGdivpetdagrlftivyillGlalfalflavlgkvl 77 
                  +++l+++f+ ++ +l  + g  k  f dalYf  +tltTiGYGdi+p+t   r+ ++++ l+G++++ + ++ + ++l
   EFC37014.1 220 IACLLILFSGIFQWLenTVGNRKIYFHDALYFIAITLTTIGYGDISPTTVPARFAVVIFFLIGITTIPIQISGIYDIL 297
                  6788999999999996533355778999********************9888**************999888776665 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   0.1     7e-09   3.1e-05      39     115 ..     367     451 ..     331     452 .. 0.84
   2 !    5.3   0.0     0.005        22      41      72 ..     842     874 ..     809     888 .. 0.86

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 7e-09
                 HTTSEEEES-TTSHHHHHHTTGGGESEEEE-SS........SHHHHHHHHHHHHHHTSSSEEEEEESSGGGHHHHHHHTTSEEEE CS
      TrkA_N  39 eeglevvvgdatdeevLeeagiekadaviaatg........ddeanilavllakelnpkkkiiaraqdpehaellkklgadvvis 115
                 +++++v++g+  d e+++ ++i++a +v  + +        +d++ i+++ ++k++n+++k++a+++  e ++++ k+ga vvi 
  EFC37014.1 367 KNNINVLCGEIMDYEMMKLLKISDAHSVFLLNSpkmgnarkEDTSVIMTTIALKNFNQNLKVYAQINLIESKHYAIKAGAKVVIC 451
                 23488***********************9998788999988889999999999******************************95 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.005
                 T.SEEEES-TTSHHHHHHTTGGGESEEEE-SSS CS
      TrkA_N  41 g.levvvgdatdeevLeeagiekadaviaatgd 72 
                 + + ++ g++ + + L++ag ++a++v+  t+d
  EFC37014.1 842 KdVYFISGNPIKSHDLRRAGFSSAQTVMYFTQD 874
                 3478999*********************99976 PP

>> Ion_trans  Ion transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   9.4   6.6e-09     3e-05      47     218 ..     140     283 ..     107     291 .. 0.73

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 6.6e-09
                 HHHHHHHHHHHTHHHHHHHCHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGGGGHHHCHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans  47 tlemllkilalgllikkrYlrdpwnilDflvvlpsllslvlseesllllsvlrlfrvlrllklisrleglrtlvtalirsvkdllnvlllllvvlfifa 145
                 +l  +  i+a +++ +   + +p  ilD++   +++  ++      l ++  +++r+lrl+ li+++++          +v ++l + ll++++l++f+
  EFC37014.1 140 LLTVVYYIVASYIQLDVDQVFQPLMILDLVLSALFIGLFFV----GLFFAKNKVLRLLRLIPLIRKIGNRGD------TVVGKVLELGLLIACLLILFS 228
                 44444444444554444445555677777666666655554....788999999999999999999999777......46678888899********** PP

                 HHHHHHHTTSCCCCCCSCCSTSSSTTTSSSSSSHHHHHHHHHHHHTTSSHHHHHHHHHHHSHHHHHHHHHHHH CS
   Ion_trans 146 ligvqlfkgklreknecaktwenpnngntnFdnfftallwlfrlmttegwgdilyatldekskvaliyfvifi 218
                  i++ l                +  n+++    f +al+++  ++tt+g+gdi ++t  ++ +  +i+f+i i
  EFC37014.1 229 GIFQWLE--------------NTVGNRKIY---FHDALYFIAITLTTIGYGDISPTTVPAR-FAVVIFFLIGI 283
                 **98888..............222233444...558*************************.55556655544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1154  (0.064365); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.89u 0.30s 00:00:01.19 Elapsed: 00:00:00.50
# Mc/sec: 7014.39
//
Query:       EFC37015.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   1.7e-107  351.0  16.7    3.8e-16   58.6   0.0    8.9 10  DUF4116          Domain of unknown function (DUF4116)
     0.0014   18.7   2.0        1.2    9.3   0.0    4.3  4  Rsbr_N           Rsbr N terminal
  ------ inclusion threshold ------
      0.028   13.5   0.0        3.6    6.6   0.0    3.1  3  TctC             Tripartite tricarboxylate transporter family
      0.065   12.6   3.6        1.2    8.5   0.1    2.5  2  GidB             rRNA small subunit methyltransferase G
       0.16   11.3   1.8        1.3    8.3   0.0    2.6  2  FAM194           FAM194 protein
        0.2   11.5   0.0       0.63    9.9   0.0    1.8  1  Peptidase_C25_C  Peptidase family C25, C terminal ig-like dom
        3.2    7.4   6.3         15    5.2   1.5    3.1  2  N6_N4_Mtase      DNA methylase


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.0   8.4e-10   2.1e-06      17      49 .]      11      43 ..       8      43 .. 0.97
   2 !   41.6   0.0   2.9e-14   7.5e-11       3      49 .]      47      93 ..      45      93 .. 0.96
   3 !   44.8   0.0   2.8e-15   7.3e-12       4      49 .]      98     143 ..      95     143 .. 0.96
   4 !   29.6   0.0   1.6e-10   4.1e-07      18      47 ..     137     166 ..     134     168 .. 0.90
   5 !   53.8   0.0   4.4e-18   1.1e-14       1      49 []     145     193 ..     145     193 .. 0.98
   6 !   58.6   0.0   1.5e-19   3.8e-16       1      49 []     170     218 ..     170     218 .. 0.99
   7 !   31.1   0.0   5.6e-11   1.4e-07       1      40 [.     195     234 ..     195     237 .. 0.93
   8 !   55.5   0.0   1.3e-18   3.4e-15       5      46 ..     302     343 ..     298     346 .. 0.93
   9 !   54.0   0.2   3.9e-18     1e-14       3      49 .]     350     396 ..     348     396 .. 0.96
  10 !   24.6   0.3   5.8e-09   1.5e-05       1      36 [.     398     435 ..     398     447 .. 0.90

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 8.4e-10
     DUF4116 17 kylseeLknDkeivlkAvkqngtalsyaseeLr 49
                ++++ e+ n+k++vl++v + g++l++as++L+
  EFC37015.1 11 QFIPIEFANNKQVVLECVSRKGNFLRFASDNLK 43
                89****************************997 PP

  == domain 2  score: 41.6 bits;  conditional E-value: 2.9e-14
     DUF4116  3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                 +vlea+ +n  a++ +++e+k+D e++l+Avk+ng ++ +++eeL+
  EFC37015.1 47 HVVLEALAQNETAFEWANPEFKKDTEFILRAVKRNGEVFHHIDEELK 93
                58*******************************************97 PP

  == domain 3  score: 44.8 bits;  conditional E-value: 2.8e-15
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +vl +vk ng++l+++s eLkn+++++++Avk +g a  +  eeLr
  EFC37015.1  98 FVLDCVKENGWILTHVSQELKNNRDFIKRAVKYYGRAVTFTNEELR 143
                 9*******************************************98 PP

  == domain 4  score: 29.6 bits;  conditional E-value: 1.6e-10
     DUF4116  18 ylseeLknDkeivlkAvkqngtalsyasee 47 
                 + +eeL+nDk ivl Av+q+g++l+y+s+ 
  EFC37015.1 137 FTNEELRNDKSIVLDAVRQDGYVLRYLSNL 166
                 5689************************86 PP

  == domain 5  score: 53.8 bits;  conditional E-value: 4.4e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+ ivl av+++g++l+yls+ ++nD+e+vl+ vkqng+al +as +Lr
  EFC37015.1 145 DKSIVLDAVRQDGYVLRYLSNLMQNDREVVLESVKQNGIALQFASFKLR 193
                 899******************************************9887 PP

  == domain 6  score: 58.6 bits;  conditional E-value: 1.5e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vle vk+ng al+++s +L+nDke+v +Avkq +++l+yas +Lr
  EFC37015.1 170 DREVVLESVKQNGIALQFASFKLRNDKEVVSEAVKQKPSSLEYASFDLR 218
                 9********************************************9998 PP

  == domain 7  score: 31.1 bits;  conditional E-value: 5.6e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 D+E+v eavk+ +s+l+y+s +L++D+e++  A+ + +++
  EFC37015.1 195 DKEVVSEAVKQKPSSLEYASFDLRHDRELIDLALAIQPIV 234
                 9********************************9887765 PP

  == domain 8  score: 55.5 bits;  conditional E-value: 1.3e-18
     DUF4116   5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 +l+avkk g +l ++s++LknDkeivl+Avkqn+ a++yas 
  EFC37015.1 302 ILQAVKKEGHYLMFASDRLKNDKEIVLEAVKQNPWAFKYASV 343
                 9***************************************96 PP

  == domain 9  score: 54.0 bits;  conditional E-value: 3.9e-18
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Ei+lea+kkngs  k++s + +nDke+v+ Avkqng++l+yas+ L+
  EFC37015.1 350 EIILEALKKNGSMVKFCSFKVRNDKELVMVAVKQNGSSLKYASDRLK 396
                 9*******************************************996 PP

  == domain 10  score: 24.6 bits;  conditional E-value: 5.8e-09
     DUF4116   1 DrEivleavkkngsalkyls..eeLknDkeivlkAvkq 36 
                 D+ ivlea+k+  +al++++  + LknD+e+ ++ v+ 
  EFC37015.1 398 DKKIVLEALKQTDKALEFANiqDLLKNDFEFKMELVRE 435
                 999***************986689***********986 PP

>> Rsbr_N  Rsbr N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.1     0.075   1.9e+02      28      90 ..      55     127 ..      50     142 .. 0.70
   2 ?    2.1   0.0     0.074   1.9e+02      66      94 ..     153     181 ..     119     193 .. 0.77
   3 ?    0.7   0.0       0.2   5.2e+02      68      95 ..     333     360 ..     272     375 .. 0.79
   4 !    9.3   0.0   0.00045       1.2      68     109 ..     383     424 ..     374     439 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.075
                 --HHHHHHHHHHH...HHHHHH-SS.-SS...TTHHHHH...HHHHHHHH.TT--HHHHHHHHHHHHHHHHHH CS
      Rsbr_N  28 isdevyektskef...vdlilssveegne...eleekle...efaerlvq.lGwpLkyltkgLqefrkvvlel 90 
                 ++++ +e  + ef    ++il +v+++ e   +++e+l+    f+   v+ +Gw L+ +++ L+  r+ + ++
  EFC37015.1  55 QNETAFEWANPEFkkdTEFILRAVKRNGEvfhHIDEELKrneAFVLDCVKeNGWILTHVSQELKNNRDFIKRA 127
                 5788888888888555578999999665511144566642225777777438999999999999888776665 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.074
                 HHHTT--HHHHHHHHHHHHHHHHHHHHH. CS
      Rsbr_N  66 lvqlGwpLkyltkgLqefrkvvlellsee 94 
                 + q G  L yl++ +q  r+vvle ++++
  EFC37015.1 153 VRQDGYVLRYLSNLMQNDREVVLESVKQN 181
                 4478999***************9999885 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.2
                 HTT--HHHHHHHHHHHHHHHHHHHHH.. CS
      Rsbr_N  68 qlGwpLkyltkgLqefrkvvlellseed 95 
                 q+ w  ky + +Lq+  +++le+l+++ 
  EFC37015.1 333 QNPWAFKYASVALQQDNEIILEALKKNG 360
                 5668888888888888888888888765 PP

  == domain 4  score: 9.3 bits;  conditional E-value: 0.00045
                 HTT--HHHHHHHHHHHHHHHHHHHHH..T--TT--HHHHHHH CS
      Rsbr_N  68 qlGwpLkyltkgLqefrkvvlellseeddvvkeeqslellee 109
                 q+G +Lky ++ L++ +k+vle+l+++d+  +  + ++ll++
  EFC37015.1 383 QNGSSLKYASDRLKVDKKIVLEALKQTDKALEFANIQDLLKN 424
                 89************************9988888888887765 PP

>> TctC  Tripartite tricarboxylate transporter family receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0     0.092   2.4e+02      86     114 ..     188     217 ..     152     231 .. 0.76
   2 ?    6.6   0.0    0.0014       3.6      75     128 ..     306     359 ..     289     366 .. 0.72
   3 ?    1.8   0.0     0.041     1e+02      88     128 ..     368     409 ..     360     420 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.092
        TctC  86 adspfkdlqelv.ayakanPgKlsyasaGi 114
                 a +++++ +e+v +++k+ P  l+yas+ +
  EFC37015.1 188 ASFKLRNDKEVVsEAVKQKPSSLEYASFDL 217
                 667777778888347799999999999865 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0014
        TctC  75 vatlplvLvvpadspfkdlqe.lvayakanPgKlsyasaGigtslhLaaellask 128
                 v +    L+  +d ++k+ +e +++++k+nP   +yas+ +   +++  e+l+++
  EFC37015.1 306 VKKEGHYLMFASD-RLKNDKEiVLEAVKQNPWAFKYASVALQQDNEIILEALKKN 359
                 4444444555444.5555555157999*********************9999976 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.041
        TctC  88 spfkdlqelva.yakanPgKlsyasaGigtslhLaaellask 128
                 +++++ +elv  ++k+n   l+yas  +    +++ e+l+++
  EFC37015.1 368 FKVRNDKELVMvAVKQNGSSLKYASDRLKVDKKIVLEALKQT 409
                 567777888752679*******************99999864 PP

>> GidB  rRNA small subunit methyltransferase G
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.1   0.00046       1.2      68     145 ..      15      99 ..      12     105 .. 0.78
   2 ?    4.0   1.0     0.011        27      72     171 ..     297     403 ..     286     415 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00046
                 HH-TTSEEEEEES-HHHHHHHHHHHHHCT-SSEEEEES-CCC......TTTTT-EEE.EEEC-SSSHHHHHHHHCCCEEEEEEEE CS
        GidB  68 iarpelkltLleslekkiaFLeevkeelklenveivearaee......kqeeekydv.vtsRAlaslnelteillkllkegglil 145
                 i +++ k ++le  ++k +FL+ ++ +lk +   ++ea a++       ++e k d+  + RA+ +  e+++ + + lk ++ ++
  EFC37015.1  15 IEFANNKQVVLECVSRKGNFLRFASDNLKSDPHVVLEALAQNetafewANPEFKKDTeFILRAVKRNGEVFHHIDEELKRNEAFV 99 
                 4455666789*********************888888888777888885666666653567999988888888888888887776 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.011
                 TSEEEEEES-HHHHHHHHHHHHHCT-SSEEEEES-CCC........TTTTT-EEEEEEC-SSSHHHHHHHHCCCEEEEEEEEEEESS--HHHHHCCHCC CS
        GidB  72 elkltLleslekkiaFLeevkeelklenveivearaee........kqeeekydvvtsRAlaslnelteillkllkegglilalKGksaedeleekeka 162
                 + ++t+l + +k  ++L  ++ +lk++  eiv + + +            ++ + ++  Al +   +++++  ++++  +++++  k++   l+ + ++
  EFC37015.1 297 DDRFTILQAVKKEGHYLMFASDRLKND-KEIVLEAVKQnpwafkyaSVALQQDNEIILEALKKNGSMVKFCSFKVRNDKELVMVAVKQNGSSLKYASDR 394
                 4459***********************.89999999987888776544555666788888888888888888888888887777777777777777777 PP

                 CCCCCEEEE CS
        GidB 163 lqlskvevl 171
                 l+++k++vl
  EFC37015.1 395 LKVDKKIVL 403
                 777766655 PP

>> FAM194  FAM194 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.0   0.00052       1.3     108     150 ..       6      48 ..       2     130 .. 0.77
   2 ?    1.5   0.4     0.061   1.6e+02     147     199 ..     367     421 ..     324     423 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00052
      FAM194 108 hskapplqpielklNeqikvrilsqdkivitFlalkesaklnv 150
                 + +++++ pie++ N+q+ +++ s++  ++ F++++ +    v
  EFC37015.1   6 TRNFTQFIPIEFANNKQVVLECVSRKGNFLRFASDNLKSDPHV 48 
                 56788999*************************9987665444 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.061
      FAM194 147 klnvGtklklidp..seklsklskaelllaelkkriqklldklqnslklpasekl 199
                 +++v    +l+    +++ s+l+ a+ +l+  kk + + l+++ + l+++++++l
  EFC37015.1 367 SFKVRNDKELVMVavKQNGSSLKYASDRLKVDKKIVLEALKQTDKALEFANIQDL 421
                 4444444443333456777888888888999999999999999999999998776 PP

>> Peptidase_C25_C  Peptidase family C25, C terminal ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00024      0.63      26      70 ..     339     384 ..     336     389 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00024
                      TT-EEEEEETTEEEEEEE-BTTEEEEE-S.--TT-SEEEEEEEETT CS
  Peptidase_C25_C  26 dgalvalSannkllGsaivasGqatlnit.piteeitltltvtaqn 70 
                      ++a val ++n+++  a+ ++G+ +   + ++ +++ l ++ ++qn
       EFC37015.1 339 KYASVALQQDNEIILEALKKNGSMVKFCSfKVRNDKELVMVAVKQN 384
                      69*********************98777788899999999999998 PP

>> N6_N4_Mtase  DNA methylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.2     0.061   1.6e+02      27     119 ..      23     113 ..      14     224 .. 0.73
   2 ?    5.2   1.5    0.0057        15      63     128 ..     276     348 ..     245     425 .. 0.57

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.061
                  HHHHHHHHHHHHHHHHHHHEEEEEEEEEEE-CCCHHTHHHHHHHHHTT.-EEEEEEEEEEESSSTTTSTCCS-B--EEEEEEEESSTT-..--- CS
  N6_N4_Mtase  27 syeeyleflekvlkevrrvLkddgsifiniddseikkelkaladeifg.gffllnvivwkkpnsmpesnkdrltsthEyilvfsknkkyllkfn 119
                   + e +++  ++l+ + + Lk d  +++    ++ +  +++ a+ +f+ +  ++ ++v+++  ++++  +++l++   ++l ++k    +l+ +
   EFC37015.1  23 VVLECVSRKGNFLRFASDNLKSDPHVVLEALAQNET--AFEWANPEFKkDTEFILRAVKRNG-EVFHHIDEELKRNEAFVLDCVKENGWILTHV 113
                  555666777777777777777777777777777765..777777777777777777777664.6666666677777777766666555543333 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0057
                  T..........HHHHHHHHHTT.-EEEEEEEEEEESSSTTTSTCCS-B--EEEEEEEESSTT-..---GGGSSBSS- CS
  N6_N4_Mtase  63 k..........elkaladeifg.gffllnvivwkkpnsmpesnkdrltsthEyilvfsknkkyllkfnldaikvpye 128
                  +           l  + de+++ +f +l+ + +  ++++   ++drl++++E +l  +k+   +  f++  + ++++
   EFC37015.1 276 DielmelmmdiSLSSVTDEQKDdRFTILQAVKK--EGHYLMFASDRLKNDKEIVLEAVKQNPWA--FKYASVALQQD 348
                  355555555555555666666644444444333..33455555556777777777777776663..33333332222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       795  (0.0443416); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 2876.18
//
Query:       EFC37016.1  [L=274]
Description: polyubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   4.7e-103  337.0  21.3    2.9e-33  113.4   0.7    4.9  5  ubiquitin        Ubiquitin family
    1.2e-48  162.8  17.0      6e-16   58.0   0.7    3.8  4  Rad60-SLD        Ubiquitin-2 like Rad60 SUMO-like
    2.5e-17   63.1   8.2    0.00025   21.4   0.1    4.8  3  Ubiquitin_2      Ubiquitin-like domain
    6.4e-13   48.4   2.5      0.011   15.7   0.0    3.7  4  TBK1_ULD         TANK binding kinase 1 ubiquitin-like domain
    3.4e-11   43.4   7.4     0.0077   16.6   0.2    3.3  3  Ubiquitin_5      Ubiquitin-like domain
    5.9e-11   42.4   3.2      0.058   13.5   0.0    4.4  4  Rad60-SLD_2      Ubiquitin-2 like Rad60 SUMO-like
      8e-10   39.2   1.6       0.12   13.0   0.1    3.2  3  DUF2407          DUF2407 ubiquitin-like domain
      5e-07   29.7   2.0       0.35   10.7   0.0    3.9  3  Sde2_N_Ubi       Silencing defective 2 N-terminal ubiquitin d
    7.2e-07   29.2  17.6        4.3    7.5   0.2    6.5  7  Ubiquitin_4      Ubiquitin-like domain
    9.6e-05   22.5   1.6        8.7    6.6   0.0    3.5  3  DUF3861          Domain of Unknown Function with PDB structur
    0.00022   21.0   5.3        9.8    6.1   0.1    4.3  4  ACT_5            ACT domain
    0.00057   20.2   0.1         26    5.3   0.0    4.0  3  DUF2870          Protein of unknown function (DUF2870)
     0.0011   19.0   0.0         20    5.3   0.0    3.7  4  RBD              Raf-like Ras-binding domain
     0.0013   18.9   4.0         19    5.5   0.1    4.0  4  YcgR_2           Flagellar protein YcgR
     0.0019   18.3  11.7         14    6.0   0.2    4.4  4  Tash_PEST        Tash protein PEST motif
     0.0022   17.4   0.2        1.1    8.5   0.0    2.5  2  Methyltrans_RNA  RNA methyltransferase
     0.0025   18.6   0.4    1.1e+02    3.6   0.0    4.0  4  Big_7            Bacterial Ig domain
     0.0041   17.1   8.4       0.23   11.5   0.0    4.1  4  DUF218           DUF218 domain
      0.005   16.7   2.8         33    4.3   0.0    4.0  4  DUF1866          Domain of unknown function (DUF1866)
      0.007   16.8   6.9        8.1    7.0   2.7    4.0  2  Phage_sheath_1N  Phage tail sheath protein beta-sandwich doma
     0.0089   16.5   4.3         38    4.9   0.0    4.1  4  UN_NPL4          Nuclear pore localisation protein NPL4
  ------ inclusion threshold ------
      0.015   15.4   4.4        1.8    8.8   0.1    4.1  4  UDP-g_GGTase     UDP-glucose:Glycoprotein Glucosyltransferase
      0.032   14.3   8.5         14    5.9   0.1    3.5  3  ProRS-C_2        Prolyl-tRNA synthetase, C-terminal
      0.065   13.8   2.0    1.2e+02    3.4   0.0    3.9  4  ACT_4            ACT domain
      0.079   12.7   7.7         38    4.1   0.1    4.2  4  PI3K_p85B        PI3-kinase family, p85-binding domain
       0.67    9.6   7.1         48    3.7   0.1    3.8  4  HAMP_N3          HAMP N-terminal domain 3
          7    6.6   5.8         20    5.2   0.2    3.7  4  Glyco_hydro_65C  Glycosyl hydrolase family 65, C-terminal dom


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.4   0.9   3.3e-34   2.2e-31       1      69 [.       3      71 ..       3      72 .. 0.98
   2 !   15.0   0.2   2.3e-05     0.015       5      25 ..      70      90 ..      69      91 .. 0.94
   3 ?    1.8   0.0      0.31     2e+02      61      72 .]     108     119 ..     103     119 .. 0.83
   4 !  113.4   0.7   4.4e-36   2.9e-33       1      72 []     124     195 ..     124     195 .. 0.99
   5 !  113.4   0.7   4.4e-36   2.9e-33       1      72 []     200     271 ..     200     271 .. 0.99

  Alignments for each domain:
  == domain 1  score: 107.4 bits;  conditional E-value: 3.3e-34
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEE CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvl 69
                i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhl l
  EFC37016.1  3 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLTL 71
                9*****************************************************************986 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 2.3e-05
                ETTSEEEEEEEETTSBHHHHH CS
   ubiquitin  5 tldgkkitleveesdtveelK 25
                tl+gk+itleve++dt+e++K
  EFC37016.1 70 TLTGKTITLEVESNDTIENVK 90
                589*****************9 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.31
                 TTEEEEEEESSC CS
   ubiquitin  61 dgstlhlvlrlr 72 
                  +stlhlvlrlr
  EFC37016.1 108 MESTLHLVLRLR 119
                 589******986 PP

  == domain 4  score: 113.4 bits;  conditional E-value: 4.4e-36
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC37016.1 124 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 195
                 9********************************************************************986 PP

  == domain 5  score: 113.4 bits;  conditional E-value: 4.4e-36
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC37016.1 200 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 271
                 9********************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.4   0.6   2.9e-18     2e-15       1      70 [.       1      69 [.       1      71 [. 0.98
   2 ?    0.5   0.0      0.85   5.6e+02       9      26 ..      72      89 ..      69      91 .. 0.80
   3 !   58.0   0.7     9e-19     6e-16       1      72 []     122     192 ..     122     192 .. 0.98
   4 !   58.0   0.7     9e-19     6e-16       1      72 []     198     268 ..     198     268 .. 0.98

  Alignments for each domain:
  == domain 1  score: 56.4 bits;  conditional E-value: 2.9e-18
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEE CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidv 70
                ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++
  EFC37016.1  1 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHL 69
                89************************************.*****************************97 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.85
                SS--EEEEEETTSBHHHH CS
   Rad60-SLD  9 dgkevkikVkptttvskL 26
                +gk+++++V+++ t++++
  EFC37016.1 72 TGKTITLEVESNDTIENV 89
                688999999999999876 PP

  == domain 3  score: 58.0 bits;  conditional E-value: 9e-19
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC37016.1 122 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 192
                 89************************************.******************************986 PP

  == domain 4  score: 58.0 bits;  conditional E-value: 9e-19
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC37016.1 198 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 268
                 89************************************.******************************986 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.1     4e-07   0.00027      17      80 ..      14      69 ..       2      73 .. 0.86
   2 !   21.4   0.1   3.8e-07   0.00025      16      80 ..     134     190 ..     122     191 .. 0.85
   3 !   21.4   0.1   3.8e-07   0.00025      16      80 ..     210     266 ..     198     267 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 4e-07
                 EEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2 17 errfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80
                 +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC37016.1 14 TLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 69
                 5667899************************99........56678999********9999995 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 3.8e-07
                  EEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2  16 serrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                   +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC37016.1 134 ITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 190
                  55678899************************99........56678999********9999995 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 3.8e-07
                  EEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2  16 serrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                   +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC37016.1 210 ITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 266
                  55678899************************99........56678999********9999995 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   1.6e-05     0.011      19      53 ..      17      51 ..       5      92 .. 0.84
   2 ?   -1.0   0.0       2.5   1.7e+03      53      83 ..      79     112 ..      60     117 .. 0.62
   3 !   15.4   0.1     2e-05     0.013      19      53 ..     138     172 ..     124     192 .. 0.86
   4 !   15.3   0.1   2.1e-05     0.014      19      53 ..     214     248 ..     199     266 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.6e-05
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53
                +++++t++++  +++++  i++++Q l+f g++l 
  EFC37016.1 17 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 51
                6899****************************973 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.5
    TBK1_ULD  53 llepslka..qnfpktsednPlillsr.eaeenv 83 
                  +e ++ +  +++p  s +  l l+s+ ++e++ 
  EFC37016.1  79 EVESNDTIenVKYPSRSTKIDLSLVSNwKMESTL 112
                 4455444411568988888888888872344445 PP

  == domain 3  score: 15.4 bits;  conditional E-value: 2e-05
    TBK1_ULD  19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 +++++t++++  +++++  i++++Q l+f g++l 
  EFC37016.1 138 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 172
                 6899****************************973 PP

  == domain 4  score: 15.3 bits;  conditional E-value: 2.1e-05
    TBK1_ULD  19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 +++++t++++  +++++  i++++Q l+f g++l 
  EFC37016.1 214 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 248
                 7899****************************974 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.4   6.3e-05     0.042      32      87 ..      11      66 ..       4      89 .. 0.88
   2 !   16.6   0.2   1.2e-05    0.0077      31      93 ..     131     194 ..     104     199 .. 0.83
   3 !   15.9   0.1   1.9e-05     0.013      32      92 ..     208     269 ..     197     273 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 6.3e-05
  Ubiquitin_5 32 kkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnsk 87
                 k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s 
   EFC37016.1 11 KTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKEST 66
                 556778888888999999*********************************99875 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 1.2e-05
  Ubiquitin_5  31 ekkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                   k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+l
   EFC37016.1 131 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLRL 194
                  466678888888999999**********************************999875467765 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 1.9e-05
  Ubiquitin_5  32 kkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLk 92 
                  k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+
   EFC37016.1 208 KTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLR 269
                  55678888888999999**********************************99987546666 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.1   0.00013     0.088      12      74 ..      10      64 ..       2      95 .. 0.73
   2 ?   -0.4   0.0       1.8   1.2e+03      50      77 ..      66      97 ..      60     118 .. 0.59
   3 !   13.5   0.0   8.8e-05     0.058      12      87 ..     131     192 ..     122     196 .. 0.72
   4 !   13.4   0.0   9.2e-05     0.061      12      87 ..     207     268 ..     198     271 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 0.00013
                 S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTT CS
  Rad60-SLD_2 12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplg 74
                 G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++  
   EFC37016.1 10 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE 64
                 55.5566778888888888888.....4566644..34559****************966543 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.8
                 CEEEEETTE..EE-..TTSBCCCCS-TTTTTT CS
  Rad60-SLD_2 50 dlklilaGk..iLe..nnktlkelrlplgevk 77
                  l l l Gk   Le  +n t+++++ p+  +k
   EFC37016.1 66 TLHLTLTGKtiTLEveSNDTIENVKYPSRSTK 97
                 56666777753344447777777777665554 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 8.8e-05
                  S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                  G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+
   EFC37016.1 131 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVL 192
                  66.6667778888888888888.....4566644..34559****************965433......3566665 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 9.2e-05
                  S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                  G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+
   EFC37016.1 207 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVL 268
                  66.6667778888888888888.....4566644..34559****************965433......3566665 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.1   0.00018      0.12      14      69 ..      13      64 ..       7     102 .. 0.74
   2 !   11.9   0.0   0.00037      0.25      14      64 ..     134     180 ..     124     193 .. 0.81
   3 !   12.0   0.0   0.00036      0.24      14      63 ..     210     255 ..     190     267 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 0.00018
     DUF2407 14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslasslklpe 69
                ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++   ++e
  EFC37016.1 13 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSDYNIQKE 64
                566666..6789999999999987..67777789**************97544443 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00037
     DUF2407  14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslass 64 
                 ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++ 
  EFC37016.1 134 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSDY 180
                 566666..6789999999999987..67777789************99874 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 0.00036
     DUF2407  14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslas 63 
                 ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++
  EFC37016.1 210 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSD 255
                 566666..6789999999999987..67777789************9986 PP

>> Sde2_N_Ubi  Silencing defective 2 N-terminal ubiquitin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.4     0.031        20       2      74 ..       2      66 ..       1     122 [. 0.71
   2 !   10.4   0.0   0.00063      0.42       2      88 ..     123     197 ..     122     198 .. 0.84
   3 !   10.7   0.0   0.00053      0.35       2      88 ..     199     273 ..     198     274 .] 0.84

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.031
  Sde2_N_Ubi  2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassads 74
                +++v+++ g+    t++l++ s+ t++++ +k++++      ++  L  + + ql  ++  +ls++  +++++
  EFC37016.1  2 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQQ-RLIFAGK-QL--EDGRTLSDYNIQKEST 66
                7888888885....888888899999999999988766654443.3333333.34..5555555555555553 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00063
  Sde2_N_Ubi   2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGG 88 
                 +++v+++ g+    t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGG
  EFC37016.1 123 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGG 197
                 8999999996....999*****************998877555.45555544.66..99999****999999....99********9 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00053
  Sde2_N_Ubi   2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGG 88 
                 +++v+++ g+    t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGG
  EFC37016.1 199 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGG 273
                 8999999996....999*****************998877555.45555554.66..99999****999999....9*********9 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.2    0.0065       4.3       1      32 [.       1      32 [.       1      36 [. 0.94
   2 ?    4.4   0.0     0.059        39      58      84 ..      43      68 ..      39      72 .. 0.85
   3 ?   -1.7   0.0       4.7   3.1e+03      10      27 ..      73      90 ..      70      97 .. 0.83
   4 !    7.5   0.2    0.0065       4.3       1      32 [.     122     153 ..     122     157 .. 0.94
   5 ?    5.2   0.0     0.033        22      58      86 ..     164     191 ..     160     194 .. 0.83
   6 !    7.5   0.2    0.0065       4.3       1      32 [.     198     229 ..     198     233 .. 0.94
   7 ?    5.2   0.0     0.033        22      58      86 ..     240     267 ..     236     270 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0065
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32
                 +++ vk l g+++ ++v++n t++++k  i+ 
   EFC37016.1  1 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 32
                 7899*************************997 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.059
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnksels 84
                 L+f g++L+ d  +l++y i+++s+l+
   EFC37016.1 43 LIFAGKQLE-DGRTLSDYNIQKESTLH 68
                 889999986.6789**********998 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 4.7
  Ubiquitin_4 10 geslevvvkqnatvkdLk 27
                 g+++ ++v++n t++++k
   EFC37016.1 73 GKTITLEVESNDTIENVK 90
                 678899999999999887 PP

  == domain 4  score: 7.5 bits;  conditional E-value: 0.0065
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32 
                  +++ vk l g+++ ++v++n t++++k  i+ 
   EFC37016.1 122 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 153
                  7899*************************997 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.033
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L+f g++L+ d  +l++y i+++s+l+ v
   EFC37016.1 164 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 191
                  889999986.6789***********9976 PP

  == domain 6  score: 7.5 bits;  conditional E-value: 0.0065
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32 
                  +++ vk l g+++ ++v++n t++++k  i+ 
   EFC37016.1 198 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 229
                  7899*************************997 PP

  == domain 7  score: 5.2 bits;  conditional E-value: 0.033
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L+f g++L+ d  +l++y i+++s+l+ v
   EFC37016.1 240 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 267
                  889999986.6789***********9976 PP

>> DUF3861  Domain of Unknown Function with PDB structure (DUF3861)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0     0.015       9.7      19      59 ..       9      49 ..       5      53 .. 0.86
   2 ?    6.6   0.0     0.013       8.7      19      59 ..     130     170 ..     124     178 .. 0.87
   3 ?    6.6   0.0     0.013       8.9      19      59 ..     206     246 ..     198     250 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.015
     DUF3861 19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59
                + k++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC37016.1  9 TGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 49
                5579*************************999887766655 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.013
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC37016.1 130 TGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 170
                 5579*************************999887776665 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.013
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC37016.1 206 TGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 246
                 5579*************************999887766655 PP

>> ACT_5  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.1     0.017        11      34      53 ..      11      30 ..       1      31 [. 0.84
   2 ?    2.4   0.0      0.21   1.4e+02      34      49 ..      74      89 ..      63      91 .. 0.82
   3 ?    6.1   0.1     0.015       9.8      33      53 ..     131     151 ..     121     152 .. 0.82
   4 ?    6.1   0.1     0.015       9.8      33      53 ..     207     227 ..     197     228 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.017
       ACT_5 34 vrieltVesersvelLsnQl 53
                 +i+l+Ves++++e++ +++
  EFC37016.1 11 KTITLEVESNDTIENVKSKI 30
                589*************9998 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.21
       ACT_5 34 vrieltVesersvelL 49
                 +i+l+Ves++++e++
  EFC37016.1 74 KTITLEVESNDTIENV 89
                479******9999976 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.015
       ACT_5  33 tvrieltVesersvelLsnQl 53 
                   +i+l+Ves++++e++ +++
  EFC37016.1 131 GKTITLEVESNDTIENVKSKI 151
                 468**************9998 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.015
       ACT_5  33 tvrieltVesersvelLsnQl 53 
                   +i+l+Ves++++e++ +++
  EFC37016.1 207 GKTITLEVESNDTIENVKSKI 227
                 468**************9998 PP

>> DUF2870  Protein of unknown function (DUF2870)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.0     0.057        38       3      20 ..      43      60 ..      41      74 .. 0.84
   2 ?    5.3   0.0     0.039        26       3      25 ..     164     186 ..     162     197 .. 0.79
   3 ?    5.3   0.0      0.04        26       3      25 ..     240     262 ..     237     272 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.057
     DUF2870  3 lWwagkelqrgkklsdyv 20
                l +agk+l++g++lsdy 
  EFC37016.1 43 LIFAGKQLEDGRTLSDYN 60
                789*************96 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.039
     DUF2870   3 lWwagkelqrgkklsdyvGkNek 25 
                 l +agk+l++g++lsdy  + e 
  EFC37016.1 164 LIFAGKQLEDGRTLSDYNIQKES 186
                 789*************9766555 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.04
     DUF2870   3 lWwagkelqrgkklsdyvGkNek 25 
                 l +agk+l++g++lsdy  + e 
  EFC37016.1 240 LIFAGKQLEDGRTLSDYNIQKES 262
                 889*************9765555 PP

>> RBD  Raf-like Ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0      0.03        20       9      47 ..      10      48 ..       9      79 .. 0.77
   2 ?   -1.8   0.0       5.2   3.5e+03       9      24 ..      73      88 ..      67      89 .. 0.82
   3 ?    4.6   0.0     0.051        34       9      42 ..     131     164 ..     130     180 .. 0.85
   4 ?    4.6   0.0     0.051        34       9      42 ..     207     240 ..     206     256 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.03
         RBD  9 gqrtvvevkpgetvrdaLekalkkRglnpsacaVylkgs 47
                g++ + ev++++t++++ +k+  k g+ p++  +   g+
  EFC37016.1 10 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGK 48
                578899**********************99877666665 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 5.2
         RBD  9 gqrtvvevkpgetvrd 24
                g++ + ev++++t+++
  EFC37016.1 73 GKTITLEVESNDTIEN 88
                5678899999999986 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.051
         RBD   9 gqrtvvevkpgetvrdaLekalkkRglnpsacaV 42 
                 g++ + ev++++t++++ +k+  k g+ p++  +
  EFC37016.1 131 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRL 164
                 578899*********************9987655 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.051
         RBD   9 gqrtvvevkpgetvrdaLekalkkRglnpsacaV 42 
                 g++ + ev++++t++++ +k+  k g+ p++  +
  EFC37016.1 207 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRL 240
                 578899*********************9987655 PP

>> YcgR_2  Flagellar protein YcgR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.1     0.029        19       3      26 ..      10      33 ..       9      45 .. 0.89
   2 ?    0.4   0.0       1.1   7.3e+02       3      22 ..      73      94 ..      72     122 .. 0.79
   3 ?    5.5   0.1     0.029        19       3      26 ..     131     154 ..     130     166 .. 0.89
   4 ?    5.5   0.1     0.029        19       3      26 ..     207     230 ..     206     242 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.029
                TSEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2  3 Gdkveieiesgdgekryksrvvdi 26
                G+ +++e+es+d  +++ks+++d 
  EFC37016.1 10 GKTITLEVESNDTIENVKSKIQDK 33
                899*******************85 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 1.1
                TSEEEEEEEETTEEEE..EEEE CS
      YcgR_2  3 Gdkveieiesgdgekr..yksr 22
                G+ +++e+es+d  ++  y+sr
  EFC37016.1 73 GKTITLEVESNDTIENvkYPSR 94
                7788888888887777777776 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.029
                 TSEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2   3 Gdkveieiesgdgekryksrvvdi 26 
                 G+ +++e+es+d  +++ks+++d 
  EFC37016.1 131 GKTITLEVESNDTIENVKSKIQDK 154
                 899*******************85 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.029
                 TSEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2   3 Gdkveieiesgdgekryksrvvdi 26 
                 G+ +++e+es+d  +++ks+++d 
  EFC37016.1 207 GKTITLEVESNDTIENVKSKIQDK 230
                 899*******************85 PP

>> Tash_PEST  Tash protein PEST motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.2     0.021        14       7      14 ..      12      19 ..      12      21 .. 0.90
   2 ?    6.0   0.2     0.021        14       7      14 ..      75      82 ..      75      84 .. 0.90
   3 ?    6.0   0.2     0.021        14       7      14 ..     133     140 ..     133     142 .. 0.90
   4 ?    6.0   0.2     0.021        14       7      14 ..     209     216 ..     209     218 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.021
   Tash_PEST  7 TIpVEigS 14
                TI++E++S
  EFC37016.1 12 TITLEVES 19
                9******* PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.021
   Tash_PEST  7 TIpVEigS 14
                TI++E++S
  EFC37016.1 75 TITLEVES 82
                9******* PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.021
   Tash_PEST   7 TIpVEigS 14 
                 TI++E++S
  EFC37016.1 133 TITLEVES 140
                 9******* PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.021
   Tash_PEST   7 TIpVEigS 14 
                 TI++E++S
  EFC37016.1 209 TITLEVES 216
                 9******* PP

>> Methyltrans_RNA  RNA methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0078       5.2       8      61 ..     111     163 ..     105     169 .. 0.80
   2 !    8.5   0.0    0.0017       1.1       2      61 ..     181     239 ..     180     248 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0078
                      HHHHHTTTT--TT-EEEEEESSSEEEEEEEEEEESSE.EEEEEEEEEE---SSSS CS
  Methyltrans_RNA   8 ahHlvkVlRlkegdeiklfdgdgkeyeaeieeiskkk.vtvkilekeeenkespe 61 
                      + Hl  VlRl+ g +i +    gk ++ e+e+++  + v+ ki++ke +++++++
       EFC37016.1 111 TLHL--VLRLRGGMQIFVKTLTGKTITLEVESNDTIEnVKSKIQDKEGIPPDQQR 163
                      5677..*************************998765157777777777776655 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0017
                      EEEHHHHHHHHTTTT--TT-EEEEEESSSEEEEEEEEEEESSE.EEEEEEEEEE---SSSS CS
  Methyltrans_RNA   2 sltdeeahHlvkVlRlkegdeiklfdgdgkeyeaeieeiskkk.vtvkilekeeenkespe 61 
                      ++++e + Hl  VlRl+ g +i +    gk ++ e+e+++  + v+ ki++ke +++++++
       EFC37016.1 181 NIQKESTLHL--VLRLRGGMQIFVKTLTGKTITLEVESNDTIEnVKSKIQDKEGIPPDQQR 239
                      5788999999..*************************998765157778777777776655 PP

>> Big_7  Bacterial Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0      0.17   1.2e+02      13      42 ..       7      34 ..       6      57 .. 0.78
   2 ?    2.7   0.0      0.33   2.2e+02      13      36 ..      70      91 ..      65     112 .. 0.72
   3 ?    3.6   0.0      0.17   1.1e+02      13      42 ..     128     155 ..     126     176 .. 0.78
   4 ?    3.6   0.0      0.18   1.2e+02      13      42 ..     204     231 ..     203     252 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.17
                -EBTSEEEEEEEEE-SS-EEEEEEEETTEE CS
       Big_7 13 tvsggtvtisasAsddggvskVefyvdgtl 42
                t++g+t+t++++ +d   +++V+  +++++
  EFC37016.1  7 TLTGKTITLEVESNDT--IENVKSKIQDKE 34
                5667788888877777..999988887766 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.33
                -EBTSEEEEEEEEE-SS-EEEEEE CS
       Big_7 13 tvsggtvtisasAsddggvskVef 36
                t++g+t+t++++ +d   +++V++
  EFC37016.1 70 TLTGKTITLEVESNDT--IENVKY 91
                5667788888888777..877776 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.17
                 -EBTSEEEEEEEEE-SS-EEEEEEEETTEE CS
       Big_7  13 tvsggtvtisasAsddggvskVefyvdgtl 42 
                 t++g+t+t++++ +d   +++V+  +++++
  EFC37016.1 128 TLTGKTITLEVESNDT--IENVKSKIQDKE 155
                 5667788888887777..999988887766 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.18
                 -EBTSEEEEEEEEE-SS-EEEEEEEETTEE CS
       Big_7  13 tvsggtvtisasAsddggvskVefyvdgtl 42 
                 t++g+t+t++++ +d   +++V+  +++++
  EFC37016.1 204 TLTGKTITLEVESNDT--IENVKSKIQDKE 231
                 5667788888887777..999988887766 PP

>> DUF218  DUF218 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.2      0.24   1.6e+02      58      74 ..      11      27 ..       2      31 .. 0.85
   2 !   11.5   0.0   0.00035      0.23      26      80 ..      40      96 ..      30     110 .. 0.82
   3 ?    2.5   0.1      0.21   1.4e+02      58      74 ..     132     148 ..     121     152 .. 0.83
   4 ?    3.4   0.1      0.11        72      58      74 ..     208     224 ..     152     228 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.24
      DUF218 58 eailledrsrnTeenar 74
                + i+le +s++T en++
  EFC37016.1 11 KTITLEVESNDTIENVK 27
                4699***********86 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.00035
      DUF218 26 agkiivsGg..gadedvseaeamaeylrelgvpeeailledrsrnTeenarfskell 80
                ++++i+ G+  +++++ s+ ++ +e  + l    + i+le +s++T en+++ ++  
  EFC37016.1 40 QQRLIFAGKqlEDGRTLSDYNIQKESTLHLTLTGKTITLEVESNDTIENVKYPSRST 96
                3479***999866799999************9977***************9977655 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.21
      DUF218  58 eailledrsrnTeenar 74 
                 + i+le +s++T en++
  EFC37016.1 132 KTITLEVESNDTIENVK 148
                 4699***********86 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.11
      DUF218  58 eailledrsrnTeenar 74 
                 + i+le +s++T en++
  EFC37016.1 208 KTITLEVESNDTIENVK 224
                 3699***********86 PP

>> DUF1866  Domain of unknown function (DUF1866)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.054        36      92     118 ..       6      32 ..       1      45 [. 0.86
   2 ?    1.1   0.1      0.48   3.2e+02      92     114 ..      69      91 ..      55     113 .. 0.78
   3 ?    4.3   0.0     0.049        33      92     118 ..     127     153 ..     120     165 .. 0.85
   4 ?    4.3   0.0     0.049        33      92     118 ..     203     229 ..     196     241 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.054
                 SEETTEEEEEEEXXXXXXXXXXXXXXX CS
     DUF1866  92 vkvlgralkiklkskdWlksleeeill 118
                 ++++g+++++++ s+d ++++++ i  
  EFC37016.1   6 KTLTGKTITLEVESNDTIENVKSKIQD 32 
                 6789*******************9943 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.48
                 SEETTEEEEEEEXXXXXXXXXXX CS
     DUF1866  92 vkvlgralkiklkskdWlkslee 114
                  +++g+++++++ s+d +++++ 
  EFC37016.1  69 LTLTGKTITLEVESNDTIENVKY 91 
                 578999**********9999975 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.049
                 SEETTEEEEEEEXXXXXXXXXXXXXXX CS
     DUF1866  92 vkvlgralkiklkskdWlksleeeill 118
                 ++++g+++++++ s+d ++++++ i  
  EFC37016.1 127 KTLTGKTITLEVESNDTIENVKSKIQD 153
                 6789*******************9943 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.049
                 SEETTEEEEEEEXXXXXXXXXXXXXXX CS
     DUF1866  92 vkvlgralkiklkskdWlksleeeill 118
                 ++++g+++++++ s+d ++++++ i  
  EFC37016.1 203 KTLTGKTITLEVESNDTIENVKSKIQD 229
                 6789*******************9943 PP

>> Phage_sheath_1N  Phage tail sheath protein beta-sandwich domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.2      0.19   1.3e+02      26      40 ..       9      27 ..       3      65 .. 0.64
   2 ?    7.0   2.7     0.012       8.1      19      62 ..      65     116 ..      54     265 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.19
                     GGGGEEEEEEEHSS....S CS
  Phage_sheath_1N 26 rGnritvevtsgad....d 40
                     +G+ it+ev+s+++    +
       EFC37016.1  9 TGKTITLEVESNDTienvK 27
                     79***********933330 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.012
                      EESSSSGGGGGEEEEEEEHSS........STTSEEEEEEETTEEEEEEEEES CS
  Phage_sheath_1N  19 gakypgerGnritvevtsgad........dsnqfdvivregdrivdaqilvt 62 
                      +++ ++ +G+ it+ev+s+++         s+++d ++  + + ++   lv 
       EFC37016.1  65 STLHLTLTGKTITLEVESNDTienvkypsRSTKIDLSLVSNWKMESTLHLVL 116
                      5677777888888888888888888888866666666666665554444443 PP

>> UN_NPL4  Nuclear pore localisation protein NPL4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.1     0.062        41      16      46 ..      13      43 ..       3      70 .. 0.83
   2 ?    0.7   0.1       1.2   7.7e+02       5      29 ..      76     100 ..      72     105 .. 0.84
   3 ?    4.9   0.0     0.058        38      16      46 ..     134     164 ..     121     191 .. 0.83
   4 ?    4.8   0.0     0.059        39      16      46 ..     210     240 ..     197     266 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.062
                EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4 16 kRieisekstlktllekvaeelkfsengfsl 46
                + +e++++ t+++ ++k++++ +++  ++ l
  EFC37016.1 13 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 43
                5689999***************999988776 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 1.2
                 -EEEEEETTEEEEEEE-TTSBHHHH CS
     UN_NPL4   5 iiiRvqSadGikRieisekstlktl 29 
                 i + v S d i  ++ +++st  +l
  EFC37016.1  76 ITLEVESNDTIENVKYPSRSTKIDL 100
                 568899*************997665 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.058
                 EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4  16 kRieisekstlktllekvaeelkfsengfsl 46 
                 + +e++++ t+++ ++k++++ +++  ++ l
  EFC37016.1 134 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 164
                 568999****************999988776 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.059
                 EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4  16 kRieisekstlktllekvaeelkfsengfsl 46 
                 + +e++++ t+++ ++k++++ +++  ++ l
  EFC37016.1 210 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 240
                 568999***************9999888776 PP

>> UDP-g_GGTase  UDP-glucose:Glycoprotein Glucosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.63   4.2e+02      81     104 ..       2      25 ..       1      29 [. 0.86
   2 ?    0.7   0.0      0.81   5.4e+02      78     104 ..      62      88 ..      41      93 .. 0.65
   3 ?    2.7   0.0       0.2   1.3e+02      79     104 ..     121     146 ..     103     150 .. 0.83
   4 ?    8.8   0.1    0.0026       1.8      52     104 ..     170     222 ..     169     226 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.63
                   EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  81 evvltsfegktlyprvkrkpgkek 104
                   ++++++++gkt++++v+ ++  e+
    EFC37016.1   2 QIFVKTLTGKTITLEVESNDTIEN 25 
                   6899************99987776 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.81
                   ---EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  78 egkevvltsfegktlyprvkrkpgkek 104
                   ++++ +  +++gkt++++v+ ++  e+
    EFC37016.1  62 QKESTLHLTLTGKTITLEVESNDTIEN 88 
                   345566677888888888877766665 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.2
                   --EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  79 gkevvltsfegktlyprvkrkpgkek 104
                   g ++++++++gkt++++v+ ++  e+
    EFC37016.1 121 GMQIFVKTLTGKTITLEVESNDTIEN 146
                   5799**************99987776 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.0026
                   EE-TTHHHHHEEEEE--SS-S--TT----EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  52 elregrssdiyeiesvgaeglsspkdegkevvltsfegktlyprvkrkpgkek 104
                   +l++gr+ + y+i++ ++ +l  + + g ++++++++gkt++++v+ ++  e+
    EFC37016.1 170 QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESNDTIEN 222
                   5889**********99999865555679*****************99987776 PP

>> ProRS-C_2  Prolyl-tRNA synthetase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.1     0.021        14       6      26 ..      16      36 ..      12      37 .. 0.85
   2 ?    5.9   0.1     0.021        14       6      26 ..     137     157 ..     133     158 .. 0.85
   3 ?    5.9   0.1     0.021        14       6      26 ..     213     233 ..     209     234 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.021
                S--....HHHHHHHCTTT-SE CS
   ProRS-C_2  6 aenvnlllenikeklsekkGv 26
                ++++n   en+k k+++k G+
  EFC37016.1 16 EVESNDTIENVKSKIQDKEGI 36
                56789*************997 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.021
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n   en+k k+++k G+
  EFC37016.1 137 EVESNDTIENVKSKIQDKEGI 157
                 56789*************997 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.021
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n   en+k k+++k G+
  EFC37016.1 213 EVESNDTIENVKSKIQDKEGI 233
                 56789*************997 PP

>> ACT_4  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.19   1.2e+02      51      75 ..      12      36 ..       6      37 .. 0.86
   2 ?   -0.6   0.0         3     2e+03      50      65 ..      74      89 ..      51      90 .. 0.67
   3 ?    3.4   0.0      0.18   1.2e+02      51      75 ..     133     157 ..     126     158 .. 0.86
   4 ?    3.4   0.0      0.18   1.2e+02      51      75 ..     209     233 ..     202     234 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.19
       ACT_4 51 kitveVkdvehLsrviakLraipgV 75
                +it+eV++ + +++v  k++  +g+
  EFC37016.1 12 TITLEVESNDTIENVKSKIQDKEGI 36
                69****************9976665 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 3
       ACT_4 50 ikitveVkdvehLsrv 65
                 +it+eV++ + +++v
  EFC37016.1 74 KTITLEVESNDTIENV 89
                4689999998888876 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.18
       ACT_4  51 kitveVkdvehLsrviakLraipgV 75 
                 +it+eV++ + +++v  k++  +g+
  EFC37016.1 133 TITLEVESNDTIENVKSKIQDKEGI 157
                 69****************9976665 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.18
       ACT_4  51 kitveVkdvehLsrviakLraipgV 75 
                 +it+eV++ + +++v  k++  +g+
  EFC37016.1 209 TITLEVESNDTIENVKSKIQDKEGI 233
                 69****************9976665 PP

>> PI3K_p85B  PI3-kinase family, p85-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.1     0.057        38       1      18 [.      13      30 ..      13      33 .. 0.92
   2 ?    2.0   0.0      0.27   1.8e+02       1      16 [.      76      91 ..      76      92 .. 0.93
   3 ?    4.1   0.1     0.057        38       1      18 [.     134     151 ..     134     154 .. 0.92
   4 ?    4.1   0.1     0.057        38       1      18 [.     210     227 ..     210     230 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.057
   PI3K_p85B  1 itlrvsreatLseiKeeL 18
                itl+v+++ t++++K+++
  EFC37016.1 13 ITLEVESNDTIENVKSKI 30
                89*************986 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.27
   PI3K_p85B  1 itlrvsreatLseiKe 16
                itl+v+++ t++++K 
  EFC37016.1 76 ITLEVESNDTIENVKY 91
                89************95 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.057
   PI3K_p85B   1 itlrvsreatLseiKeeL 18 
                 itl+v+++ t++++K+++
  EFC37016.1 134 ITLEVESNDTIENVKSKI 151
                 89*************986 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.057
   PI3K_p85B   1 itlrvsreatLseiKeeL 18 
                 itl+v+++ t++++K+++
  EFC37016.1 210 ITLEVESNDTIENVKSKI 227
                 89*************986 PP

>> HAMP_N3  HAMP N-terminal domain 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.1     0.072        48      32      43 .]      20      31 ..      20      31 .. 0.93
   2 ?   -0.9   0.0       1.9   1.2e+03      32      39 ..      83      90 ..      83      91 .. 0.93
   3 ?    3.7   0.1     0.072        48      32      43 .]     141     152 ..     141     152 .. 0.93
   4 ?    3.7   0.1     0.072        48      32      43 .]     217     228 ..     217     228 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.072
                HHHHHHHHHHH- CS
     HAMP_N3 32 netieqvRgnLk 43
                n+tie+v+++++
  EFC37016.1 20 NDTIENVKSKIQ 31
                9********986 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.9
                HHHHHHHH CS
     HAMP_N3 32 netieqvR 39
                n+tie+v+
  EFC37016.1 83 NDTIENVK 90
                9******8 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.072
                 HHHHHHHHHHH- CS
     HAMP_N3  32 netieqvRgnLk 43 
                 n+tie+v+++++
  EFC37016.1 141 NDTIENVKSKIQ 152
                 9********986 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.072
                 HHHHHHHHHHH- CS
     HAMP_N3  32 netieqvRgnLk 43 
                 n+tie+v+++++
  EFC37016.1 217 NDTIENVKSKIQ 228
                 9********986 PP

>> Glyco_hydro_65C  Glycosyl hydrolase family 65, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1       1.8   1.2e+03      25      40 ..       8      23 ..       6      26 .. 0.75
   2 ?    5.2   0.2      0.03        20      19      40 ..      65      86 ..      63      89 .. 0.88
   3 ?   -0.0   0.0       1.3   8.6e+02      25      40 ..     129     144 ..     117     147 .. 0.74
   4 ?   -0.0   0.0       1.3   8.6e+02      25      40 ..     205     220 ..     193     223 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.8
                     EESSEEEEEEESSSTE CS
  Glyco_hydro_65C 25 vtpeevtvtlesgepl 40
                     +t +++t+++es + +
       EFC37016.1  8 LTGKTITLEVESNDTI 23
                     5778888888887766 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.03
                     EEEEEEEESSEEEEEEESSSTE CS
  Glyco_hydro_65C 19 rrLrVrvtpeevtvtlesgepl 40
                     ++L++++t +++t+++es + +
       EFC37016.1 65 STLHLTLTGKTITLEVESNDTI 86
                     79***************98877 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 1.3
                      EESSEEEEEEESSSTE CS
  Glyco_hydro_65C  25 vtpeevtvtlesgepl 40 
                      +t +++t+++es + +
       EFC37016.1 129 LTGKTITLEVESNDTI 144
                      5667777777776655 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 1.3
                      EESSEEEEEEESSSTE CS
  Glyco_hydro_65C  25 vtpeevtvtlesgepl 40 
                      +t +++t+++es + +
       EFC37016.1 205 LTGKTITLEVESNDTI 220
                      5667777777776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       315  (0.0175693); expected 358.6 (0.02)
Passed bias filter:                      201  (0.0112109); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              27  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.42
# Mc/sec: 1945.97
//
Query:       EFC37017.1  [L=400]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-30  106.1   0.0    2.7e-30  105.5   0.0    1.3  1  AAA             ATPase family associated with various cellula
    2.9e-05   23.9   0.6    0.00019   21.2   0.1    2.3  2  AAA_24          AAA domain
    3.1e-05   24.5   0.0    6.7e-05   23.4   0.0    1.7  1  AAA_18          AAA domain
      4e-05   24.1   0.0    8.4e-05   23.0   0.0    1.5  1  AAA_16          AAA ATPase domain
    4.1e-05   23.9   0.0     0.0001   22.6   0.0    1.6  1  AAA_22          AAA domain
     0.0004   20.4   1.0       0.27   11.1   0.0    2.5  2  ATPase_2        ATPase domain predominantly from Archaea
    0.00096   19.2   0.0     0.0018   18.2   0.0    1.4  1  TsaE            Threonylcarbamoyl adenosine biosynthesis prot
      0.001   19.5   0.0     0.0021   18.4   0.0    1.6  1  RNA_helicase    RNA helicase
     0.0018   17.9   0.0      0.023   14.3   0.0    2.1  2  AAA_25          AAA domain
     0.0026   17.5   0.0     0.0054   16.5   0.0    1.4  1  RuvB_N          Holliday junction DNA helicase RuvB P-loop do
     0.0031   17.7   0.0     0.0053   16.9   0.0    1.5  1  AAA_33          AAA domain
     0.0033   16.6   0.1      0.027   13.6   0.1    2.3  1  DUF815          Protein of unknown function (DUF815)
     0.0035   17.4   0.0     0.0089   16.1   0.0    1.8  1  AAA_14          AAA domain
     0.0038   17.4   0.0     0.0093   16.1   0.0    1.6  1  AAA_2           AAA domain (Cdc48 subfamily)
     0.0038   17.1   0.1     0.0081   16.1   0.1    1.7  1  NACHT           NACHT domain
     0.0053   16.3   0.0       0.01   15.3   0.0    1.4  1  AAA_7           P-loop containing dynein motor region
     0.0059   15.9   0.0     0.0096   15.2   0.0    1.3  1  TIP49           TIP49 P-loop domain
     0.0065   16.7   0.0      0.023   14.9   0.0    1.9  2  AAA_28          AAA domain
     0.0068   16.4   0.1      0.018   15.1   0.1    1.7  1  AAA_5           AAA domain (dynein-related subfamily)
     0.0098   15.6   0.0      0.027   14.2   0.0    1.7  2  IstB_IS21       IstB-like ATP binding protein
  ------ inclusion threshold ------
      0.013   15.3   0.0      0.025   14.3   0.0    1.4  1  AAA_30          AAA domain
      0.013   15.3   0.0      0.021   14.6   0.0    1.5  1  AAA_11          AAA domain
      0.017   13.8   0.0      0.024   13.3   0.0    1.3  1  AAA_13          AAA domain
      0.026   14.3   0.1      0.074   12.8   0.1    1.6  1  Cytidylate_kin  Cytidylate kinase
       0.03   14.8   0.0      0.056   13.9   0.0    1.6  1  AAA_17          AAA domain
      0.038   13.3   0.0        0.1   11.9   0.0    1.7  1  ATPase          KaiC
      0.043   14.2   0.1       0.14   12.5   0.0    1.9  1  AAA_19          AAA domain
      0.058   12.6   0.0       0.15   11.2   0.0    1.6  1  KAP_NTPase      KAP family P-loop domain
      0.086   12.8   0.0       0.21   11.5   0.0    1.6  1  Rad17           Rad17 P-loop domain
      0.098   12.0   0.0       0.22   10.9   0.0    1.5  1  Mg_chelatase    Magnesium chelatase, subunit ChlI
       0.16   10.9   0.2       0.54    9.2   0.0    1.8  2  AAA_6           Hydrolytic ATP binding site of dynein motor r


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  105.5   0.0   4.6e-33   2.7e-30       1     131 [.     150     296 ..     150     297 .. 0.90

  Alignments for each domain:
  == domain 1  score: 105.5 bits;  conditional E-value: 4.6e-33
                 EEEESSTTSSHHHHHHHHHHHH..........THEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTS...TS.EEEEEETGGGHHHHH....TTCCCHH CS
         AAA   1 vllyGppGtGKTllakavakel..........gvefleisgsellskyvgesekkirelfkeakeka...kp.silfiDEidalaksr....sgsesee 81 
                 vllyGppGtGKT+l+k +a++l          g +++ei+ ++l+sk+++es k + +lfk++ e     +  +++++DE+++l+ +r    sgse ++
  EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKLairmshrypsGGTLIEINSHSLFSKWFSESGKLVMKLFKKIFEIVedeESfVCVLMDEVESLTAARksalSGSEPSD 248
                 79*******************84544444444466***************************97766677445************************** PP

                 HHHHHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHHHSTTSSEEEETT CS
         AAA  82 eervvnqLlteldgvkkkeskvivigatnrpdkldpallrgRfdrkieie 131
                 + rvvn+Llt+ld++k++++ v++++++n  + +d a++ +R+d+k++i+
  EFC37017.1 249 SIRVVNALLTQLDQLKRYKN-VLILTTSNITEAIDLAFV-DRADIKQYIG 296
                 *****************966.******************.******9986 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       8.6     5e+03     124     142 ..      65      83 ..      62      90 .. 0.82
   2 !   21.2   0.1   3.4e-07   0.00019       3     127 ..     148     326 ..     147     347 .. 0.69

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 8.6
      AAA_24 124 nvifiahektrkdedpege 142
                 +v fi h  + +de+p +e
  EFC37017.1  65 DVTFIIHVFKSTDEEPIEE 83 
                 7999999999999999877 PP

  == domain 2  score: 21.2 bits;  conditional E-value: 3.4e-07
      AAA_24   3 lkiliyGpsgiGKTtlakelgpkplfi......................dtekGlksldadkfpdieswedfldevvel.................... 59 
                 + +l+yGp+g+GKT+l+k l  + l i                        +  + +l  + f++             +                    
  EFC37017.1 148 RVVLLYGPPGTGKTSLCKGL-AQKLAIrmshrypsggtlieinshslfsKWFSESGKLVMKLFKK-------------Ifeivedeesfvcvlmdeves 232
                 5799****************.88888834444444444444444444442222222233333333.............234444444444444444555 PP

      AAA_24  60 ...........................aaeladyktlviDtideleelclaevirqnekaeskedkgdgkG.ygelaeefrrllkklqelrknvif 127
                                             ++l++yk + i t + + e ++  + +++ +++ + + +++kG y+ l+ ++++l++ ++  + nvi+
  EFC37017.1 233 ltaarksalsgsepsdsirvvnalltqLDQLKRYKNVLILTTSNITEAIDLAFVDRADIKQYI-GPPSAKGrYSILRSCLVELMR-VSVIKPNVII 326
                 588888888888888888888888888899999******999999999999999999996666.99999*****99999999886.4444446665 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.0   1.2e-07   6.7e-05       1      67 [.     150     219 ..     150     280 .. 0.76

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 1.2e-07
      AAA_18   1 IlltGtpGvGKttlakeLskrlgfgvnlrdvakenglllevdpe.....aldeskrldedkldklldaleen 67 
                 +ll G+pG+GKt+l+k L+++l   ++ ++  + +g+l+e + +     +++es +l+++  +k+++++e  
  EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKL--AIRMSHRYPSGGTLIEINSHslfskWFSESGKLVMKLFKKIFEIVEDE 219
                 799******************9..667777677777777777666666677777777777777766666655 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   1.4e-07   8.4e-05      25     132 ..     148     265 ..     140     274 .. 0.63

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 1.4e-07
      AAA_16  25 elvllsGesGvGKsslvrellralekd.......ggiflrgkcdqlesaipy......sa.laqalareellrqlldeaesaeleawrekleealaavp 109
                 ++vll+G++G+GK+sl + l++ l  +       gg +++ + ++l     +      s  l+  l++ ++++ ++de++   +  +  + ++a++  +
  EFC37017.1 148 RVVLLYGPPGTGKTSLCKGLAQKLAIRmshrypsGGTLIEINSHSL-----FskwfseSGkLVMKLFK-KIFEIVEDEESFVCVLMDEVESLTAAR-KS 239
                 689******************9998887888887344444444444.....21222224557777745.888888888777666666665555555.56 PP

      AAA_16 110 elagaea...srllellkrllallsr 132
                 +l+g+e+    r+ ++l   l++l+r
  EFC37017.1 240 ALSGSEPsdsIRVVNALLTQLDQLKR 265
                 66666663335555555555555555 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   1.8e-07    0.0001       6      91 ..     148     265 ..     145     280 .. 0.55

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 1.8e-07
      AAA_22   6 gilvvtGesGtGKTtllrrlleqldeeakaee........erpevvfvtlpsst..sskdllrellralglelka......................er 72 
                 ++++++G++GtGKT l++ l+++l ++ ++++         +++ +f +  s++     +l++++++++++e +                       e+
  EFC37017.1 148 RVVLLYGPPGTGKTSLCKGLAQKLAIRMSHRYpsggtlieINSHSLFSKWFSESgkLVMKLFKKIFEIVEDEESFvcvlmdevesltaarksalsgsEP 246
                 5789********************766666665555555422222222222222234445555555555554444555555555544444444444444 PP

      AAA_22  73 lsseellealeqalrarav 91 
                  +s ++++al  +l++ ++
  EFC37017.1 247 SDSIRVVNALLTQLDQLKR 265
                 4444444444444444444 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.0   0.00047      0.27      20      44 ..     147     171 ..     144     184 .. 0.87
   2 !    7.3   0.3     0.007       4.1      91     170 ..     194     280 ..     183     290 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00047
    ATPase_2  20 neiyfiYGpegsGKtaLlkeiienl 44 
                 n+++++YGp g GKt+L k ++++l
  EFC37017.1 147 NRVVLLYGPPGTGKTSLCKGLAQKL 171
                 6899***************999887 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.007
    ATPase_2  91 leeilkeksklvfkaielllekikkkgkkiiiiiDelqklidlgln..........gaellvkeLlnliesltkekhlcvviclsSeglf 170
                 + + ++e  klv k +++++e ++++   + +++De+  l     +           +  +v++Ll+ +++ +k+++ ++++ +s  +  
  EFC37017.1 194 FSKWFSESGKLVMKLFKKIFEIVEDEESFVCVLMDEVESLT--AARksalsgsepsDSIRVVNALLTQLDQ-LKRYKNVLILTTSNITEA 280
                 56778899******************999*********999..3334577777776666788888888877.677777777777766655 PP

>> TsaE  Threonylcarbamoyl adenosine biosynthesis protein TsaE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.0   3.2e-06    0.0018      18      46 ..     143     174 ..     126     186 .. 0.79

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 3.2e-06
                 H...TEEEEEEESTTSSHHHHHHHHHHHTT-- CS
        TsaE  18 l...gdvilLeGdLGaGKTtlvrglakalgve 46 
                 l   ++v+lL+G+ G+GKT l++gla++l ++
  EFC37017.1 143 LiswNRVVLLYGPPGTGKTSLCKGLAQKLAIR 174
                 2344789*********************9886 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   3.6e-06    0.0021       1      26 [.     150     175 ..     150     229 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.6e-06
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkkl 26 
                   ++lyGp+g+GK++l+k La++l+ ++
    EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKLAIRM 175
                   689*******************9666 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   3.9e-05     0.023      28      58 ..     142     172 ..     138     186 .. 0.85
   2 ?    1.2   0.0      0.42   2.4e+02     130     184 ..     209     272 ..     189     275 .. 0.60

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3.9e-05
      AAA_25  28 gllpagelallaGapgtGKttlaldlalava 58 
                 +l+  + ++ll+G+pgtGKt l+  la ++a
  EFC37017.1 142 NLISWNRVVLLYGPPGTGKTSLCKGLAQKLA 172
                 67777899**************999887766 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.42
      AAA_25 130 vdaleaaieevegvrlvviDplsralgg.......densnsd..vgalvealeriarrtgaavl 184
                 ++++ + +e+ e  + v  D + +++++       +e s+s   v+al+++l++++r +++ +l
  EFC37017.1 209 FKKIFEIVEDEESFVCVLMDEVESLTAArksalsgSEPSDSIrvVNALLTQLDQLKRYKNVLIL 272
                 555555555544455666665555444433222114544444645*********9877766555 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   9.3e-06    0.0054      36      62 ..     150     176 ..     144     191 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 9.3e-06
      RuvB_N  36 vllyGpPGlGkttlakiiakelgvklk 62 
                 vllyGpPG Gkt+l+k +a++l +++ 
  EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKLAIRMS 176
                 89******************9987664 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   9.1e-06    0.0053       1      24 [.     149     172 ..     149     280 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 9.1e-06
      AAA_33   1 lvllvGlpGsGKstlaerllkklg 24 
                 +vll G+pG+GK+ l ++l++kl+
  EFC37017.1 149 VVLLYGPPGTGKTSLCKGLAQKLA 172
                 89******************9987 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.1   4.7e-05     0.027      56      92 ..     150     193 ..     144     296 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 4.7e-05
      DUF815  56 vLLwGarGtGKSslvkallneyaeeg.......Lrlievekedl 92 
                 vLL+G  GtGK sl+k l +++a +          lie++ ++l
  EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKLAIRMshrypsgGTLIEINSHSL 193
                 8******************9988766556666677777777766 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   1.5e-05    0.0089       2      81 ..     147     238 ..     146     289 .. 0.67

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.5e-05
      AAA_14   2 rkilvitGaRrvGKTtllkqlikell.......vkkesilyinldderdkkladpe....kllelileklke.ekktylflDEiqevpewek 81 
                 ++++++ G+  +GKT l+k l+++l         +    ++in  +   k ++++     kl + i+e +++ e   ++++DE+  ++ ++k
  EFC37017.1 147 NRVVLLYGPPGTGKTSLCKGLAQKLAirmshryPSGGTLIEINSHSLFSKWFSESGklvmKLFKKIFEIVEDeESFVCVLMDEVESLTAARK 238
                 6899******************99998888765333445555555544443333223333455555555444356677******99955444 PP

>> AAA_2  AAA domain (Cdc48 subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   1.6e-05    0.0093       6     104 ..     150     261 ..     147     284 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.6e-05
                 EEEE--TTSSHHHHHHHHHHHTT-..........-EEEEEGGG---..----THHHHHHHHHTTT-HHHHTTS.EEEEETGGG----...--------- CS
       AAA_2   6 illlgptgvGktelakalaellfv......kkekkliradaselle..eeevehlvsrligappgyvgaeegG.ivllDEidKihpk...essgadvSr 92 
                 +ll gp g+Gkt l k la+ l +       +  +li ++  +l      e+ +lv +l  +   +v+ ee+   vl+DE++  ++      sg++ S 
  EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKLAIrmshryPSGGTLIEINSHSLFSkwFSESGKLVMKLFKKIFEIVEDEESFvCVLMDEVESLTAArksALSGSEPSD 248
                 6899******************999999997788999999999988677899*********************559******97775546556666665 PP

                 H.HHHHHHHHHHH CS
       AAA_2  93 e.gVqrdLLqile 104
                    V+++LL  l+
  EFC37017.1 249 SiRVVNALLTQLD 261
                 4378888886666 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.1   1.4e-05    0.0081       1      26 [.     148     173 ..     148     281 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.4e-05
                 SCEEEEC-TTTCHHHHHHHHHHHHCT CS
       NACHT   1 rlvilqGeaGsGKTtLlqklalawae 26 
                 r+v+l G++G GKT L ++la+++a 
  EFC37017.1 148 RVVLLYGPPGTGKTSLCKGLAQKLAI 173
                 79*********************985 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   1.8e-05      0.01      27      58 ..     141     172 ..     129     179 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1.8e-05
       AAA_7  27 elllknkkpvllvGptGtGKtviikdllkkld 58 
                 + l++ ++ vll+Gp GtGKt+++k l +kl 
  EFC37017.1 141 QNLISWNRVVLLYGPPGTGKTSLCKGLAQKLA 172
                 56889999*****************9999886 PP

>> TIP49  TIP49 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   1.7e-05    0.0096      50     118 ..     147     213 ..     136     291 .. 0.63

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.7e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-S-EE CS
       TIP49  50 GravLlaGpsgtGktalaiaiskelgedvpfvalsgsevyslevkktevltqalrksigvrikeekevl 118
                  r+vLl Gp+gtGkt+l  +++++l+  +     sg+ +   e++   ++ + +  s ++ +k  k+++
  EFC37017.1 147 NRVVLLYGPPGTGKTSLCKGLAQKLAIRMSHRYPSGGTL--IEINSHSLFSKWFSESGKLVMKLFKKIF 213
                 489*********************997776655555544..3444444444444444444444444444 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0     4e-05     0.023       2      25 ..     150     174 ..     149     215 .. 0.83
   2 ?   -1.7   0.0       5.1   2.9e+03     100     119 ..     257     276 ..     247     319 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 4e-05
      AAA_28   2 ivitGgestGKTtlleaLaar.gyp 25 
                 + + G+++tGKT+l++ La++  ++
  EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKlAIR 174
                 7899***************865444 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 5.1
      AAA_28 100 leaaarekrydlvfllppap 119
                 l++  + kry+ v++l ++ 
  EFC37017.1 257 LTQLDQLKRYKNVLILTTSN 276
                 55566688999999998765 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.1   3.1e-05     0.018       2      23 ..     150     171 ..     149     186 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 3.1e-05
                 EEEE--SSSSHHHHHHHGGGGB CS
       AAA_5   2 vlLvGppGtgKselaerlaaal 23 
                 vlL GppGtgK++l + la+ l
  EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKL 171
                 89**************999987 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.0   4.7e-05     0.027      40      73 ..     140     174 ..     118     180 .. 0.78
   2 ?   -2.7   0.0       7.5   4.3e+03     143     148 ..     271     276 ..     251     299 .. 0.53

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 4.7e-05
   IstB_IS21  40 tlsfiekkenivllGpsGvGKshlaialgve.avr 73 
                   + i+ +  ++l Gp+G+GK+ l   l+++ a+r
  EFC37017.1 140 DQNLISWNRVVLLYGPPGTGKTSLCKGLAQKlAIR 174
                 56677888999******************983444 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 7.5
   IstB_IS21 143 iiitsn 148
                 i+ tsn
  EFC37017.1 271 ILTTSN 276
                 333332 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   4.3e-05     0.025      14      41 ..     143     170 ..     138     178 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 4.3e-05
      AAA_30  14 ltsgdrvavltGpAGtGKttalkalrea 41 
                 l s +rv++l Gp+GtGKt + k+l++ 
  EFC37017.1 143 LISWNRVVLLYGPPGTGKTSLCKGLAQK 170
                 556678*****************99875 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   3.7e-05     0.021      14      42 ..     144     172 ..     135     277 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 3.7e-05
      AAA_11  14 lseseitliqGPPGtgKTktivellsqll 42 
                 +s + ++l+ GPPGtgKT+   +l ++l+
  EFC37017.1 144 ISWNRVVLLYGPPGTGKTSLCKGLAQKLA 172
                 5556789*************999999995 PP

>> AAA_13  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   4.2e-05     0.024      12      54 ..     143     185 ..     130     280 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 4.2e-05
      AAA_13  12 ledfkriNliYGwNGaGKTtLSrllrslelgetepkfangsie 54 
                 l   +r+ l+YG  G+GKT+L++ l++    ++++++++g   
  EFC37017.1 143 LISWNRVVLLYGPPGTGKTSLCKGLAQKLAIRMSHRYPSGGTL 185
                 555778889*****************98888999999888553 PP

>> Cytidylate_kin  Cytidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   0.00013     0.074       4      25 ..     153     174 ..     150     178 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 0.00013
                     E-STTSSHHHHHHHHHHHHT-E CS
  Cytidylate_kin   4 DGPagsGKssvaralaeklglk 25 
                      GP g+GK s+++ la+kl ++
      EFC37017.1 153 YGPPGTGKTSLCKGLAQKLAIR 174
                     6******************987 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   9.6e-05     0.056       1      22 [.     153     174 ..     153     247 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 9.6e-05
                 EE-TTSSHHHHHHHHHHHHTEE CS
      AAA_17   1 lGgPGsGKgtqceklvekygft 22 
                 +G+PG GK+ +c+ l++k+ + 
  EFC37017.1 153 YGPPGTGKTSLCKGLAQKLAIR 174
                 7*****************9554 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00018       0.1      18      94 ..     146     233 ..     138     285 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00018
      ATPase  18 egrvvlitGepGtGKtifa....lqFlikgaekygepgvfvtveepa.......edlrenakslGwdlekleeegklaiidasesaee 94 
                  +rvvl++G pGtGKt ++    ++ +i+   +y   g ++ +++++       e+ +  +k +   +e +e+e++++ + + e ++ 
  EFC37017.1 146 WNRVVLLYGPPGTGKTSLCkglaQKLAIRMSHRYPSGGTLIEINSHSlfskwfsESGKLVMKLFKKIFEIVEDEESFVCVLMDEVESL 233
                 579*************986111145566666666666777777777666655555555556666666666666666666655555555 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   0.00024      0.14      10      34 ..     147     171 ..     141     185 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00024
      AAA_19  10 ekvllvtaGpGtGKTrvlkhivall 34 
                 ++v+l+ ++pGtGKT + k+  + l
  EFC37017.1 147 NRVVLLYGPPGTGKTSLCKGLAQKL 171
                 789*************999877665 PP

>> KAP_NTPase  KAP family P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00027      0.15      22      87 ..     149     222 ..     139     257 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00027
  KAP_NTPase  22 vvgLygkWGsGKssllnkledelkefa............kpvrflfaefnawsfkggddavaellaaLadaleeeygq 87 
                 vv Lyg+ G+GK+sl++ l ++l  +              + ++lf +   w f+++ ++v +l++ +++ +e e ++
  EFC37017.1 149 VVLLYGPPGTGKTSLCKGLAQKLAIRMshrypsggtlieINSHSLFSK---W-FSESGKLVMKLFKKIFEIVEDEESF 222
                 899****************99998886677777776665444444433...3.3344688888888888888887765 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00037      0.21      45      74 ..     147     176 ..     139     191 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00037
       Rad17  45 kriLLisGPsGCgkstvvkvLskelgiklr 74 
                 +r++L+ GP+G gk+   k L+++l+i++ 
  EFC37017.1 147 NRVVLLYGPPGTGKTSLCKGLAQKLAIRMS 176
                 5899********************999875 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00038      0.22      25      46 ..     150     171 ..     145     187 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00038
  Mg_chelatase  25 lllvGppGsGKtmlakrlpsll 46 
                   +ll+GppG+GKt l k l++ l
    EFC37017.1 150 VLLYGPPGTGKTSLCKGLAQKL 171
                   89************99987655 PP

>> AAA_6  Hydrolytic ATP binding site of dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.0   0.00093      0.54      36      59 ..     151     174 ..     142     183 .. 0.88
   2 ?   -1.3   0.0       1.4   8.3e+02     246     288 ..     192     234 ..     178     263 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00093
       AAA_6  36 apaGpagtGKtEtvkdLakalakq 59 
                  ++Gp gtGKt  +k La++la  
  EFC37017.1 151 LLYGPPGTGKTSLCKGLAQKLAIR 174
                 578******************976 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.4
       AAA_6 246 vnlpklvaeDvplfkglisdlFpgvelpesdyeeleeaieevl 288
                 + ++k  +e  +l ++l +++F+ ve +es    l +++e+ +
  EFC37017.1 192 SLFSKWFSESGKLVMKLFKKIFEIVEDEESFVCVLMDEVESLT 234
                 4455666666666666666666666666555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (400 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       722  (0.04027); expected 358.6 (0.02)
Passed bias filter:                      607  (0.0338558); expected 358.6 (0.02)
Passed Vit filter:                       109  (0.00607954); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              31  [number of targets reported over threshold]
# CPU time: 0.71u 0.34s 00:00:01.05 Elapsed: 00:00:00.50
# Mc/sec: 2400.06
//
Query:       EFC37018.1  [L=694]
Description: WD40 repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.6e-17   62.1  12.0      0.003   18.3   0.1    8.7 10  WD40           WD domain, G-beta repeat
    2.9e-10   40.3   0.0       0.06   13.6   0.0    5.3  6  ANAPC4_WD40    Anaphase-promoting complex subunit 4 WD40 doma
    0.00078   18.3   0.2        1.4    7.5   0.0    4.1  4  Nucleoporin_N  Nup133 N terminal like
     0.0021   16.9   0.0     0.0048   15.7   0.0    1.7  1  Vps16_N        Vps16, N-terminal region
  ------ inclusion threshold ------
      0.016   13.9   0.0      0.033   12.8   0.0    1.5  1  Nup160         Nucleoporin Nup120/160


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.041   1.5e+02      22      38 .]       6      22 ..       2      22 .. 0.82
   2 !   18.3   0.1   8.4e-07     0.003       2      38 .]      32      67 ..      31      67 .. 0.84
   3 ?   -0.3   0.0      0.64   2.3e+03      13      37 ..      94     123 ..      81     124 .. 0.54
   4 ?   -1.7   0.0       1.9   6.7e+03      22      36 ..     160     174 ..     149     176 .. 0.64
   5 !    5.9   0.0    0.0075        27      23      37 ..     286     299 ..     265     300 .. 0.85
   6 ?    4.1   0.3     0.027        95       8      38 .]     317     347 ..     311     347 .. 0.75
   7 ?   -3.9   0.1         5   1.8e+04      25      33 ..     403     411 ..     400     415 .. 0.66
   8 !   16.9   0.0   2.4e-06    0.0087       9      37 ..     435     464 ..     425     464 .. 0.86
   9 !   11.5   0.0   0.00012      0.43       8      38 .]     486     515 ..     480     515 .. 0.83
  10 ?   -2.9   0.0       4.5   1.6e+04      16      34 ..     580     598 ..     578     599 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.041
                SSEEEEEETTSEEEEEE CS
        WD40 22 gawlasGsdDgtvriWd 38
                  ++++G+ D++ +++d
  EFC37018.1  6 LELIVTGCVDHSMKVFD 22
                56799**********98 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 8.4e-07
                EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38
                +cl+t   H ++vtslaf+ d     sGs D  v+iW+
  EFC37018.1 32 SCLQTMFSHvKPVTSLAFHFDLII--SGSSDMLVKIWK 67
                68889778********88777555..9*88*******6 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.64
                 EEEEEEETTSSE............EEEEETTSEEEEE CS
        WD40  13 vtslafspdgaw............lasGsdDgtvriW 37 
                 +++l       w            ++ G+++gt++++
  EFC37018.1  94 ISAL-------WaspedlsgeqgeIVVGTMKGTCYVY 123
                 5555.......22222223555555669999999997 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 1.9
                 SSEEE.EEETTSEEEE CS
        WD40  22 gawla.sGsdDgtvri 36 
                 +++++ +G  D+ v++
  EFC37018.1 160 SNMMVsTGF-DNVVKF 174
                 455541666.*99996 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.0075
                 SEEEEEETTSEEEEE CS
        WD40  23 awlasGsdDgtvriW 37 
                 +++++Gs D+++ iW
  EFC37018.1 286 RLITAGS-DNKIVIW 299
                 4577899.******* PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.027
                 ESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +G  + +ts+ + +dg   ++G+d g++ +W+
  EFC37018.1 317 KGDkTEITSFIYVDDGIG-CTGHDSGHITLWN 347
                 566444888877777777.68**********8 PP

  == domain 7  score: -3.9 bits;  conditional E-value: 5
                 EEEEETTSE CS
        WD40  25 lasGsdDgt 33 
                 l+++s Dg+
  EFC37018.1 403 LVTASFDGS 411
                 456776886 PP

  == domain 8  score: 16.9 bits;  conditional E-value: 2.4e-06
                 SSSS.EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   9 GHss.vtslafspdgawlasGsdDgtvriW 37 
                 +H+  + +l f+p  + +++G+ Dg +r+W
  EFC37018.1 435 AHNReILCLVFNPMDKTVITGGNDGMIRFW 464
                 78557************************* PP

  == domain 9  score: 11.5 bits;  conditional E-value: 0.00012
                 ESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +GH s v s+    dg++l+++s+D+t+ +W+
  EFC37018.1 486 SGHkSAVVSM--VLDGNFLFTASEDQTIGLWN 515
                 5995557666..559****************8 PP

  == domain 10  score: -2.9 bits;  conditional E-value: 4.5
                 EEEETTSSEEEEEETTSEE CS
        WD40  16 lafspdgawlasGsdDgtv 34 
                 ++f+ +++ +++G+ Dg++
  EFC37018.1 580 VSFDEEKDEIFAGDIDGKI 598
                 7788888889999999987 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.0   1.7e-05      0.06      25      89 ..     178     238 ..     162     241 .. 0.88
   2 ?    3.0   0.0     0.034   1.2e+02      33      82 ..     315     363 ..     294     373 .. 0.80
   3 !   11.4   0.0   8.7e-05      0.31      27      70 ..     426     469 ..     401     495 .. 0.83
   4 ?    4.7   0.0      0.01        37      43      84 ..     492     532 ..     473     544 .. 0.79
   5 ?    1.2   0.0      0.13   4.8e+02      28      65 ..     521     555 ..     503     585 .. 0.65
   6 ?   -1.6   0.0      0.95   3.4e+03      15      61 ..     548     597 ..     535     611 .. 0.59

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.7e-05
  ANAPC4_WD40  25 ngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                  +g+ v++    ++d+++ ++ W  + + L  +++ g+v +++  +g++  s+  ++e   tcl++
   EFC37018.1 178 SGKTVFSK--FTRDERICGMDWDDEHEELITVTESGKVDIYQYRTGETSLSFYFGKE--PTCLSF 238
                  67777777..7899*************************************999988..899987 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.034
  ANAPC4_WD40  33 eedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksek 82 
                  + ++++ e++s+ +  dg + + +++ g++ l + e g+    ++ ++++
   EFC37018.1 315 TPKGDKTEITSFIYVDDG-IGCTGHDSGHITLWNLERGREYVDIKLHQNS 363
                  567788899999998777.6799****************99999999886 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 8.7e-05
  ANAPC4_WD40  27 qrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesg 70 
                  + v++++++++++e+ +L ++p +k    + +dg +r+  +e+ 
   EFC37018.1 426 NPVFKVKQNAHNREILCLVFNPMDKTVITGGNDGMIRFWAIEDD 469
                  679**********************************9998875 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.01
  ANAPC4_WD40  43 sLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekav 84 
                   ++   dg++L  a +d ++ l ++++ + + sl+ ++  av
   EFC37018.1 492 VVSMVLDGNFLFTASEDQTIGLWNVNTREKLASLESDTG-AV 532
                  4455679**********************9999988776.35 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.13
  ANAPC4_WD40  28 rvwtleedkedsevrsLaWkpdgklLavaysdgevrll 65 
                  ++ +l  +++ + v ++++  +g+l+   +++g+v++ 
   EFC37018.1 521 KLASL--ESDTGAVLGMCYAGNGRLMS-WFKEGRVEVW 555
                  44444..67788999999999999775.4667777664 PP

  == domain 6  score: -1.6 bits;  conditional E-value: 0.95
  ANAPC4_WD40  15 edgellvfRlng.....qrvwtleedkedsevrsLaWkpdgklLavaysdge 61 
                  ++g+++v R+n        ++ +  ++++ e + +++ ++   +  +  dg+
   EFC37018.1 548 KEGRVEVWRFNAekgsqDILFRF--EDKKAEFSTVSFDEEKDEIFAGDIDGK 597
                  56677777777633332223333..455555555555555555555555555 PP

>> Nucleoporin_N  Nup133 N terminal like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.0    0.0004       1.4     192     231 ..     180     219 ..     141     246 .. 0.82
   2 ?    0.5   0.0     0.054   1.9e+02     196     240 ..     262     303 ..     237     330 .. 0.73
   3 ?    1.1   0.0     0.037   1.3e+02     194     243 ..     431     476 ..     339     491 .. 0.81
   4 !    3.1   0.0    0.0088        32     201     242 ..     489     528 ..     480     531 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0004
                    SS--G----GG-EEEEEEECCTCEEEEEETTSEEEEEEEE CS
  Nucleoporin_N 192 pgvlsgasereeivqlridssrrilytlsskgvirvydls 231
                    + v+s + ++e+i+ +  d++++ l+t+++ g++ +y+  
     EFC37018.1 180 KTVFSKFTRDERICGMDWDDEHEELITVTESGKVDIYQYR 219
                    456778999****************************955 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.054
                    G..----GG-EEEEEEECCT...CEEEEEETTSEEEEEEEETTCEE-EEE CS
  Nucleoporin_N 196 s..gasereeivqlridssr...rilytlsskgvirvydlsasngesslk 240
                        ++  ++iv +    +r    +l+t+ s+ +i ++++s        k
     EFC37018.1 262 HkeHKYHTDAIVGIGLNTKRtatARLITAGSDNKIVIWEVS--------K 303
                    34446888999999999999999999999*********999........3 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.037
                    --G----GG-EEEEEEECCTCEEEEEETTSEEEEEEEETTCEE-EEEEEE CS
  Nucleoporin_N 194 vlsgasereeivqlridssrrilytlsskgvirvydlsasngesslksdi 243
                    v++ +  + ei +l+  +  + ++t  ++g ir++ ++ +  +  l+++i
     EFC37018.1 431 VKQ-NAHNREILCLVFNPMDKTVITGGNDGMIRFWAIE-D--DIPLVGEI 476
                    444.5667789999999999****************99.4..55555555 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.0088
                    GG-EEEEEEECCTCEEEEEETTSEEEEEEEETTCEE-EEEEE CS
  Nucleoporin_N 201 reeivqlridssrrilytlsskgvirvydlsasngesslksd 242
                    ++++v+++ d   + l+t+s++ +i  ++++++++  sl+sd
     EFC37018.1 489 KSAVVSMVLDG--NFLFTASEDQTIGLWNVNTREKLASLESD 528
                    56788888888..79****************99887777765 PP

>> Vps16_N  Vps16, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   1.4e-06    0.0048      65     119 ..     174     232 ..     111     264 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.4e-06
     Vps16_N  65 iyslsGrlLkk.llwnkeklvklgwsee.eeLivvqkagavlvygl.lGek..sfsigee 119
                   ++sG+ + +  + + e +  ++w++e eeLi v+++g+v +y+   Ge   sf  g+e
  EFC37018.1 174 FTDYSGKTVFSkFTRD-ERICGMDWDDEhEELITVTESGKVDIYQYrTGETslSFYFGKE 232
                 5678888776624444.9*******976268*************9735777666666665 PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   9.3e-06     0.033     216     258 ..     486     527 ..     471     539 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 9.3e-06
                 ECEEEEET.....TTTEEEEEETT-EEEEEETTTTEEEEEEE- CS
      Nup160 216 alsldvavavveigqtylfalsrdgkLrvWnlltgkclatidl 258
                     +++v++v  + ++lf++s d+++ +Wn++t   la+ + 
  EFC37018.1 486 SGHKSAVVSMVL-DGNFLFTASEDQTIGLWNVNTREKLASLES 527
                 344566666776.*********************999988665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (694 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       568  (0.0316805); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.78u 0.35s 00:00:01.12 Elapsed: 00:00:00.55
# Mc/sec: 3827.79
//
Query:       EFC37019.1  [L=460]
Description: SANT domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.7e-07   29.6   0.3    1.3e-06   28.5   0.3    1.6  1  Myb_DNA-binding  Myb-like DNA-binding domain
      0.006   16.5   0.0      0.016   15.1   0.0    1.7  1  Myb_DNA-bind_7   Myb DNA-binding like
  ------ inclusion threshold ------
      0.054   13.8   0.1       0.14   12.4   0.1    1.7  1  Myb_DNA-bind_6   Myb-like DNA-binding domain


Domain annotation for each model (and alignments):
>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5   0.3   2.2e-10   1.3e-06       2      41 ..     414     454 ..     413     454 .. 0.91

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 2.2e-10
                      SSSBHHHHHHHHHHHHHHTTCHHHHHHHHT.SS-HHHHHHH CS
  Myb_DNA-binding   2 gkWteeEdelLleavkkhGnrWkkIaerlg.gRtekqcrsr 41 
                      g W++eE+e +l ++k+ G +W++Ia+++  +R + q+ s+
       EFC37019.1 414 GTWSKEEHEMFLLGLKEAGRNWELIANKYIkSRVRSQVASH 454
                      89***********************995555******9997 PP

>> Myb_DNA-bind_7  Myb DNA-binding like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   2.7e-06     0.016       8      45 ..     413     451 ..     408     455 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.7e-06
  Myb_DNA-bind_7   8 tkkWskeetekFYkaLsqfGtDFslia.klfpkrtrrql 45 
                     + +Wskee e+F  +L++ G +++lia k+ ++r r+q+
      EFC37019.1 413 HGTWSKEEHEMFLLGLKEAGRNWELIAnKYIKSRVRSQV 451
                     568***********************8357788999997 PP

>> Myb_DNA-bind_6  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   2.3e-05      0.14       1      35 [.     416     451 ..     416     454 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.3e-05
  Myb_DNA-bind_6   1 WteeEdeiLlklvekygndWknIaeal.nrRtpkqc 35 
                     W++eE e  l + ++ g++W++Ia+ + + R  +q+
      EFC37019.1 416 WSKEEHEMFLLGLKEAGRNWELIANKYiKSRVRSQV 451
                     ***********************9886588888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       728  (0.0406046); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2643.05
//
Query:       EFC37020.1  [L=525]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.8e-24   85.8   0.4    4.2e-24   84.6   0.4    1.6  1  DUF525      ApaG domain
    6.8e-08   32.2   0.4     0.0002   21.2   0.2    2.7  2  F-box       F-box domain
    0.00018   21.3   0.9     0.0065   16.3   0.4    2.5  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> DUF525  ApaG domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.6   0.4   7.1e-28   4.2e-24       4      86 ..     412     502 ..     410     503 .. 0.89

  Alignments for each domain:
  == domain 1  score: 84.6 bits;  conditional E-value: 7.1e-28
                 -BTTB--EEEEEEEEEEE-S....SS-EEEEEEEEEEEE....TTS-EEEEEEESBTTB--EE-TTEEEEEEEEEEESSSEEEEEEEEEEE CS
      DUF525   4 sspeeekyvfaYsirienes....eesvqLlsRhweitd....adgkveevegeGvvGeqPlLepgesFeYtSgvsletpsGsmeGsytmv 86 
                  spee +y+f+Y+i+i++++    ++s++L+sRhwei+     ++++ e v+g+GvvG +P+++pg+ F+Y+S+++ e++ G+m+G++tm+
  EFC37020.1 412 YSPEEVHYYFSYRIKITMDKnestQNSCKLVSRHWEIYLtsdvQNETPEVVDGPGVVGLYPTVTPGSVFTYNSCTETEEEIGFMKGYFTMK 502
                 68999************999999889***********97333344446677***************************************8 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.2   3.3e-08    0.0002       2      46 ..      30      74 ..      29      76 .. 0.87
   2 !    8.4   0.0   0.00034         2      22      42 ..     435     455 ..     432     458 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 3.3e-08
                HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHHH CS
       F-box  2 tlsrLPsevlrhILerLplsdllalrrVSkgwrilidsdrlwcks 46
                +l++LPse+l h++e+++ +dl  +++V   ++++ +s   w+ +
  EFC37020.1 30 PLLQLPSEILTHCFEYMNVRDLTQISSVHSVLHQIERSQIVWKSK 74
                799*************************88888887777777765 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00034
                 HHHHHCTT-HHHHHHHTTHHH CS
       F-box  22 dllalrrVSkgwrilidsdrl 42 
                 +  ++ +VS++w i++ sd+ 
  EFC37020.1 435 TQNSCKLVSRHWEIYLTSDVQ 455
                 5668*************9975 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.4   1.1e-06    0.0065       2      46 ..      32      75 ..      31      77 .. 0.89
   2 ?    2.9   0.0     0.017     1e+02      20      32 ..     435     447 ..     421     453 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.1e-06
  F-box-like  2 srLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrlv 46
                ++LP EiL + F+y++ +dL++++ V +  +++ ++   +W+  +
  EFC37020.1 32 LQLPSEILTHCFEYMNVRDLTQISSVHSVLHQIERSQ-IVWKSKC 75
                68************************99999996666.9998877 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.017
  F-box-like  20 dLlrlalVCrrWr 32 
                 ++ ++ lV+r+W 
  EFC37020.1 435 TQNSCKLVSRHWE 447
                 5668********5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (525 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       732  (0.0408277); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.41u 0.24s 00:00:00.64 Elapsed: 00:00:00.40
# Mc/sec: 3983.36
//
Query:       EFC37021.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.3e-08   33.7   0.6      3e-07   30.1   0.2    2.1  2  adh_short     short chain dehydrogenase
    2.6e-06   27.2   0.0    1.2e-05   25.0   0.0    1.8  2  adh_short_C2  Enoyl-(Acyl carrier protein) reductase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.2   3.4e-11     3e-07      76     144 ..      28      92 ..       9      95 .. 0.85
   2 ?    1.6   0.0     0.018   1.6e+02     169     192 ..     143     166 ..     114     169 .. 0.77

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 3.4e-11
                 SSESEEEE---SS--SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-T CS
   adh_short  76 gkldvLvnNAGitgsgpfselseeewervievNltgvflltravlpamlkqssGrIvnvsSvagkvpva 144
                 +k+dv++nNAG+  +++ ++++++++  +++v   g fl+ +++ +++   +++rI+ vsS+++k+ ++
  EFC37021.1  28 EKIDVIINNAGL--VVSKEKTQAQQVSTTFSVCHLGHFLMNHLLKDYLN--ENARIIIVSSNVAKMMFP 92 
                 89**********..78888899999***************999999965..9************99876 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.018
                 GGTEEEEEEEESSBSSHHHHHHCT CS
   adh_short 169 ptgirvnavaPGlvdTdmakelre 192
                 +++  vn+++PG + T++ +++ +
  EFC37021.1 143 NKKLAVNMLHPGTMMTNLPEKALD 166
                 35599***********99887665 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.0   1.4e-09   1.2e-05      68     137 ..      28      93 ..      11     100 .. 0.90
   2 ?   -0.7   0.0     0.095   8.5e+02     163     184 ..     145     166 ..     142     178 .. 0.75

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 1.4e-09
                   SSEEEEEE-----EGCSS-GGGH-HHHHHHHHHHHTHHHHHHHHHHHHHCTSCCEEEEEEEGGGTSBSTT CS
  adh_short_C2  68 gklDilvnnagiapklkgpfletsreefdraldvnlyslfllakaalplmkeggsivnlssvgaervvpn 137
                   +k+D+++nnag + +     ++t+ +++ ++++v   + fl+ + ++ +++e+++i+ +ss  a++++p+
    EFC37021.1  28 EKIDVIINNAGLVVS----KEKTQAQQVSTTFSVCHLGHFLMNHLLKDYLNENARIIIVSSNVAKMMFPK 93 
                   79***********99....3589*******************************************9997 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.095
                   TEEEEEEEE--BHCTGGGGSTT CS
  adh_short_C2 163 giRvNavspgpikTlaasgikg 184
                   +  vN  +pg + T++ +++ +
    EFC37021.1 145 KLAVNMLHPGTMMTNLPEKALD 166
                   6679**********99555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1075  (0.0599587); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2006.14
//
Query:       EFC37022.1  [L=787]
Description: chloride channel ClC-3 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      4e-95  319.1  23.9      4e-95  319.1  23.9    1.5  2  Voltage_CLC  Voltage gated chloride channel
    2.3e-08   34.3   0.0      0.012   16.0   0.0    2.6  2  CBS          CBS domain
  ------ inclusion threshold ------
      0.033   13.9   0.5        5.1    6.8   0.0    2.3  2  Per1         Per1-like family


Domain annotation for each model (and alignments):
>> Voltage_CLC  Voltage gated chloride channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.2       0.4   2.4e+03     163     188 ..      77     102 ..      66     113 .. 0.76
   2 !  319.1  23.9   6.6e-99     4e-95       2     353 ..     164     552 ..     163     553 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.4
                  GHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Voltage_CLC 163 elilfvllGilgGllgalfvrlllkv 188
                   +i+++l+G  +G+++ +  + + ++
   EFC37022.1  77 GWIMTFLIGAWIGIFASIVDKGMEWL 102
                  56788889999999888877766665 PP

  == domain 2  score: 319.1 bits;  conditional E-value: 6.6e-99
                  HHHHHHHCCCCC-GGGSC-SHHHHHHHCTTSS--..-HHHHHHHHHHHHHHHHCTT-S-BTHHHHHHHHHHHHHHHHHHTT..--SHHHHH.HHHHHH CS
  Voltage_CLC   2 ggllagllvklvapeaagsGipevkaalngvkgp..lslrvllvkflasvltvgsGlslGreGplvqiGAavgsglsrllkl.srndrdrr.lvaaGa 95 
                  +++l++++vk +ap aagsGipevk++l g+ ++  l + +l+vk++++vl+vgsGl+lG+eGp+v++G++vg+++sr+++  ++n++++r +++a +
   EFC37022.1 164 MATLSAWFVKSLAPWAAGSGIPEVKTILGGFVIKgcLGIMTLIVKIIGLVLAVGSGLTLGKEGPMVHVGGCVGNVFSRIFSKyRNNEAKKReMISASC 261
                  7899***************************************************************************6553777888889****** PP

                  HHHHHHHHT-HHHHHHHHCTTTSTSS--TTHHHHHHHHHHHHHHHHHHCTTS-S.....-.T---...--GGGHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Voltage_CLC  96 AAGiAAaFnaPlgGvlfalEevsrefslrallpvfvasvvaalvlrlllgeepa.....fgeveslfalsllelilfvllGilgGllgalfvrlllkv 188
                  AAG+A+aF++P gG+lf+lEe+s++f +++l+++f+a+v++al+l++++    +     ++ ++   +++++eli+f++lGi+gGllgalf++l++ +
   EFC37022.1 262 AAGVACAFGTPAGGTLFSLEELSSYFPPKTLFRTFFACVIGALTLQIINPRP-SgkivlYS-ISYHVNWKWFELIAFIFLGIVGGLLGALFTKLNISF 357
                  ************************************************5444.33555443.555449****************************99 PP

                  HHHHHCHHCHHHHHHHHHHHHHHHHHHHCCCSCC.CSSSSC.CHHHHHCTT-S-.................HHHHHH...HHHHHHHHHHHHHCTT-C CS
  Voltage_CLC 189 erlfrkleklkikkrlepalvgllvgllglllpasvlgggy.eliasllegstl.................llsllllllllllkllataltlgsgvp 268
                   + +rk++ + ++++le + +++l+++l+++  + + ++++ +lia l+e++ +                  +++  l++ ++l++++ +lt+g+++p
   EFC37022.1 358 IKNVRKKY-FGKWPILETIGLTILTSVLCYWN-E-YSRMPMsDLIARLFENTCTenssadsifvelcdptnFWAMGKLMISFVLRFILLSLTVGIKIP 452
                  98777764.5567899***************7.4.566665478999996655567789999******9998888999******************** PP

                  SBSHHHHHHHHHHHHHHHHHHHHHH-C..............TSSC....HHHHHHCCTHHHHHCCS-HHHHHHHHHHCC--GCCHHHHHHHHHHHHHH CS
  Voltage_CLC 269 gGifaPsLviGAalGrlvglvlalllp..............gaass.dpgafalvGmaaflagvtrapltaiviviEltgdlelllplmlavliAkav 351
                  +G+++PsL+iGA++G lvg +++++                g+ s+  pg++a++G+a +l+gv+r +++++vi++Eltg+le+l+p+ml+v++Ak+v
   EFC37022.1 453 SGVLVPSLAIGACYGTLVGSIMKYVQLtfpdspffqecyagGEGSCvVPGMYAVIGAATMLGGVCRITVSLAVIMFELTGGLEYLVPIMLSVMFAKWV 550
                  ***********************9944666999999****97788899************************************************** PP

                  HC CS
  Voltage_CLC 352 ad 353
                  +d
   EFC37022.1 551 GD 552
                  97 PP

>> CBS  CBS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   2.5e-06     0.015       3      55 ..     585     643 ..     583     645 .. 0.75
   2 !   16.0   0.0   2.1e-06     0.012      25      56 ..     700     730 ..     682     731 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.5e-06
                 HHSBS...SCEEEETTSBHHHHHHHHHHHT...SSEEEEE.ETTT..BEEEEEEHHHHHHHH CS
         CBS   3 dimtr...dvvtvppdttleealelmrekg...vsrlPVV.dedg..klvGivtlrDllral 55 
                 +imt+   +v  + + +t++e+ + + ++g   + ++P+V + ++  +++G +t+  l +al
  EFC37022.1 585 HIMTThklKV-IFVEGATVGEVRQSLLREGlklY-GFPIVdN-SDdrRVLGFITQAALQDAL 643
                 6666653333.667789********98***9966.*****63.33358******98887766 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 2.1e-06
                 HHHHTSSEE.EEEETTTBEEEEEEHHHHHHHHH CS
         CBS  25 mrekgvsrl.PVVdedgklvGivtlrDllrall 56 
                 +r  gv r+ +V+  + klvGi+t++Dl+++l+
  EFC37022.1 700 FRAMGV-RYcLVL-HNSKLVGIITKKDLVKWLH 730
                 544457.552488.6888************997 PP

>> Per1  Per1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1    0.0029        17      83     136 ..     120     174 ..      82     208 .. 0.78
   2 ?    6.8   0.0   0.00085       5.1      35      57 ..     363     385 ..     350     438 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0029
        Per1  83 kkvylvyalvslnaw.vwSaiFHtrDveltEklDYfsAgavvlsglylavvrlfr 136
                 ++ + v   +++  w +wS iF + +++    +DYf+ + + ++   l++ ++ +
  EFC37022.1 120 RCCVEVPVGIKCEDWkTWSEIFGIYETNGAYAFDYFAYIFIAVCMATLSAWFVKS 174
                 44455556777888878*******************9877776666665555544 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.00085
        Per1  35 vqFhGKWpflrllgiqEpasvlf 57 
                 ++++GKWp l  +g+  + svl 
  EFC37022.1 363 KKYFGKWPILETIGLTILTSVLC 385
                 69************998888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (787 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       714  (0.0398237); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.48
# Mc/sec: 4903.79
//
Query:       EFC37023.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0049   16.5  39.5        0.1   12.1  38.9    2.9  1  Filament        Intermediate filament protein
  ------ inclusion threshold ------
      0.024   14.6  13.1      0.024   14.6  13.1    4.2  4  FlxA            FlxA-like protein
       0.11   10.0  38.1       0.14    9.7  38.1    1.1  1  DUF3584         Protein of unknown function (DUF3584)
       0.13   11.8   0.2       0.13   11.8   0.2    1.8  2  Adeno_E1B_19K   Adenovirus E1B 19K protein / small t-antigen
       0.17   12.2  13.9       0.32   11.3   4.0    3.0  3  DUF948          Bacterial protein of unknown function (DUF948
       0.82    7.8  40.7          2    6.5  38.4    1.9  2  EzrA            Septation ring formation regulator, EzrA
       0.98    9.8  10.6       0.55   10.6   0.2    3.3  3  kleA_kleC       Uncharacterized KorC regulated protein A
        1.1    7.8   3.4        1.9    6.9   0.0    1.8  2  FUSC            Fusaric acid resistance protein family
        1.1    9.7  11.6       0.31   11.5   8.0    1.7  2  DUF2894         Protein of unknown function (DUF2894)
        2.6    8.0   8.6       0.57   10.1   2.7    2.2  2  Baculo_IE-1     Baculovirus immediate-early protein (IE-0)
        2.8    7.5  40.5         32    4.1  35.5    3.2  2  Lebercilin      Ciliary protein causing Leber congenital amau
        4.5    7.4   6.9         41    4.4   3.6    2.9  3  Hydrolase_6     Haloacid dehalogenase-like hydrolase
        4.6    7.2  13.5         45    4.0   1.9    3.3  2  ApoO            Apolipoprotein O


Domain annotation for each model (and alignments):
>> Filament  Intermediate filament protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1  38.9   7.6e-05       0.1     100     275 ..       4     192 ..       2     193 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.6e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXX.. CS
    Filament 100 evEaelkalrkdldeatlarvdLekkvesLkeelaflkkvheeEvkelqkqvs...eqvlvevdaarkld.Lteilkeiraqyeelaeknreeaeew.. 192
                 ++E+e+ +l+++++++t   + ++k+ + L++++++  ++ eeE+k+ qk+++   +  + e+ +++++  +++ ++++ra+  e+ ++ ++ea++   
  EFC37023.1   4 KLEDEISNLNQQINAETSVALSVQKRADFLHDQCKLFESLKEEEIKQYQKHIQevnDFFTSETSEGKQIKtIEKQINDLRAKIQEQDSHIQKEAKKHql 102
                 68**************************************************98755667888888888889**********99999999999876412 PP

                 X....XXXXXXXXXXXXXXXXXXXX-...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament 193 y....kskleelqeaaeknsealrsa...keeitelrrqiqsleieleslkkqkasleaqlaeleerleaeleklqeklseleeelaeir 275
                      ++  ++++++ +k++++ ++    ++  +++r qi+  ++ +++  ++++ le +++ ++++l++  ++++ ++++ ++  ++++
  EFC37023.1 103 IhseiQTVSNNIKKEEKKKQDHFKQQqqkEQKEKQIRSQIDYHQTSMAEKLQEREELELAISQMQDELQTLTSETNTQIQKRDAFCKKLK 192
                 311113344455555555555554431003344567888888888888888888888888888888888888888888888887777666 PP

>> FlxA  FlxA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.9     0.025        35      19      39 ..       2      22 ..       1      42 [. 0.63
   2 ?   14.6  13.1   1.7e-05     0.024      23      79 ..      45     100 ..      40     101 .. 0.84
   3 ?    9.1  33.4    0.0009       1.2      14      90 ..      67     139 ..      63     150 .. 0.72
   4 ?   -2.8  13.0       4.6   6.4e+03      40      79 ..     145     184 ..     136     197 .. 0.64

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.025
        FlxA 19 iasLqkQiknlqkqLkelses 39
                i +L+ +i+nl++q++  ++ 
  EFC37023.1  2 IDKLEDEISNLNQQINAETSV 22
                556666666666666665554 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1.7e-05
        FlxA  23 qkQiknlqkqLkelses.deltkeekkkqqqliqaQIqqlqaQIaqlqqqqaekaqek 79 
                 +++ik++qk ++e+ +  +++t e   kq+++i++QI++l+a I+   +  +++a++ 
  EFC37023.1  45 EEEIKQYQKHIQEVNDFfTSETSE--GKQIKTIEKQINDLRAKIQEQDSHIQKEAKKH 100
                 478************997666666..7*****************99888777777665 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.0009
        FlxA  14 gsasqiasLqkQiknlqkqLkelsesdeltkeekkkqqqliqaQIqqlqaQIaqlqqqqaekaqekqqsekeeksks 90 
                 +  +qi++++kQi++l  +++e  +     ke   k+ qli ++Iq + + I++ ++++++  +++qq+e++ek+  
  EFC37023.1  67 SEGKQIKTIEKQINDLRAKIQEQDSH--IQKE--AKKHQLIHSEIQTVSNNIKKEEKKKQDHFKQQQQKEQKEKQIR 139
                 55566666666666666666664444..2222..599*****************99999998888888888887754 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 4.6
        FlxA  40 deltkeekkkqqqliqaQIqqlqaQIaqlqqqqaekaqek 79 
                  +++  ek + +++++  I+q+q +++ l ++ + + q+ 
  EFC37023.1 145 HQTSMAEKLQEREELELAISQMQDELQTLTSETNTQIQKR 184
                 4556666777777777777777777777777766665554 PP

>> DUF3584  Protein of unknown function (DUF3584)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  38.1   9.9e-05      0.14     301     482 ..       3     193 ..       1     198 [. 0.82

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 9.9e-05
     DUF3584 301 delkeaidelnqelsaakaklaakeselealeeqkkkye...dadieklkadldqlpsirseleeleeeldaltekhqdvqekydrrkqkikeeleeel 396
                 d+l+++i++lnq+++a+       +++ + l +q k +e   +++i +++++  ++  + ++ +   ++++ ++++++d+ +k +++ + i++e ++++
  EFC37023.1   3 DKLEDEISNLNQQINAETSVALSVQKRADFLHDQCKLFEslkEEEIKQYQKHIQEVNDFFTSETSEGKQIKTIEKQINDLRAKIQEQDSHIQKEAKKHQ 101
                 7899999*********99999999************997444799**********999999999999************************99988765 PP

     DUF3584 397 ...eklker.leaireekdrl.kaaieealealesqlrkqleaqkeelneeekel.esrlselklrldsatateEeleqieeadealekaqe 482
                    ++++   +++ +eek+++ + +++++ e+ e+q r+q + ++++++e+ +e  e +l+  +++ +  t t+E+++qi++ d+ ++k ++
  EFC37023.1 102 lihSEIQTVsNNIKKEEKKKQdHFKQQQQKEQKEKQIRSQIDYHQTSMAEKLQEReELELAISQMQDELQTLTSETNTQIQKRDAFCKKLKQ 193
                 333556665345556677666666777778888888999988888887776655514578888888888999***********999988765 PP

>> Adeno_E1B_19K  Adenovirus E1B 19K protein / small t-antigen
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   9.6e-05      0.13      15      70 ..      15      71 ..       3      85 .. 0.82
   2 ?   -2.8   0.2         3   4.1e+03      33      50 ..     104     121 ..      95     135 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 9.6e-05
  Adeno_E1B_19K 15 rllegasnrtsvlkRflFggrlaklvyrvkeeyeeefeelleeneglfdslel.get 70
                   ++ +++s   sv kR  F  +  kl  + kee+ +++++ ++e + +f s  + g++
     EFC37023.1 15 QINAETSVALSVQKRADFLHDQCKLFESLKEEEIKQYQKHIQEVNDFFTSETSeGKQ 71
                   5567889999**************************************998652444 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3
  Adeno_E1B_19K  33 ggrlaklvyrvkeeyeee 50 
                    ++++  + +++k+e++++
     EFC37023.1 104 HSEIQTVSNNIKKEEKKK 121
                    555666667777777665 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0       0.8   1.1e+03      29      43 ..       3      17 ..       1      45 [. 0.63
   2 ?   11.3   4.0   0.00023      0.32      28      86 ..      48     116 ..      37     118 .. 0.85
   3 ?    6.5   0.5    0.0074        10      30      58 ..     158     186 ..     136     197 .. 0.69

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.8
      DUF948 29 deaaatieelekqvd 43
                d++++ i +l++q++
  EFC37023.1  3 DKLEDEISNLNQQIN 17
                344444444444443 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00023
      DUF948  28 ldeaaatieele..........kqvdpilkevedllakvnelledvneklekvdplteavadlgesvse 86 
                 +++ +++i+e++          kq++ i k+++dl ak++e  + ++++ +k + + ++++++++++++
  EFC37023.1  48 IKQYQKHIQEVNdfftsetsegKQIKTIEKQINDLRAKIQEQDSHIQKEAKKHQLIHSEIQTVSNNIKK 116
                 5566666666666666666899*******************999**********************975 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0074
      DUF948  30 eaaatieelekqvdpilkevedllakvne 58 
                 e++ +i +++++++ ++ e+++ ++k  +
  EFC37023.1 158 ELELAISQMQDELQTLTSETNTQIQKRDA 186
                 55556667777777777777766666544 PP

>> EzrA  Septation ring formation regulator, EzrA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  38.4    0.0015         2     281     428 ..       3     154 ..       1     182 [. 0.89
   2 ?    0.2   3.5      0.12   1.6e+02     365     408 ..     154     197 ..     146     199 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0015
                 HHHHHHHHHHHHHHHHHHHHHHHHTTTSSSSSHHHHT-....-HHHHTTGGG-TTTS-GGGSSTTTSTTHHHHHHHHHHHHHHHHHHHHHHS-SS---S CS
        EzrA 281 ktieeeidsLyddlekEveAkkeveknlkelkeklehl....ekqnkelkeeldrlkqsYeLseeeleklrelekelkelekdyeeleekleekkvaYS 375
                 +++e+ei +L +++++E      v+k+ + l ++++      e+++k+ ++ ++++++ ++ + +e ++++ +ek++++l+++++e + +++++   + 
  EFC37023.1   3 DKLEDEISNLNQQINAETSVALSVQKRADFLHDQCKLFeslkEEEIKQYQKHIQEVNDFFTSETSEGKQIKTIEKQINDLRAKIQEQDSHIQKEAKKHQ 101
                 689*************************9999998765222257899**************************************************** PP

                 TTGGGTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        EzrA 376 elqeeleeleekleeieekqeeileslkslrkdEkrAreqldeikkelkeikr 428
                  +++e++++++++++ e+k ++ +++ ++ +++Ek+ r q+d  ++ + e  +
  EFC37023.1 102 LIHSEIQTVSNNIKKEEKKKQDHFKQQQQKEQKEKQIRSQIDYHQTSMAEKLQ 154
                 ******************************************99999887555 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.12
                 HHHS-SS---STTGGGTHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        EzrA 365 ekleekkvaYSelqeeleeleekleeieekqeeileslkslrkd 408
                 ++ ee + a S++q+el++l+++ ++  +k + + ++lk+l+++
  EFC37023.1 154 QEREELELAISQMQDELQTLTSETNTQIQKRDAFCKKLKQLENE 197
                 44556667777777777777777777777777777777777765 PP

>> kleA_kleC  Uncharacterized KorC regulated protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.2     0.086   1.2e+02      16      60 ..       6      50 ..       1      60 [. 0.78
   2 ?   10.6   0.2    0.0004      0.55      34      65 ..      73     104 ..      68     113 .. 0.87
   3 ?    1.6   0.6      0.26   3.5e+02      22      60 ..     145     183 ..     133     187 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.086
   kleA_kleC 16 atdlvarRdkiAaklaeAeeLvrqaeeLRakvyeesaaLedrakk 60
                ++++ +  ++i a    A   +++a+ L  + ++ ++  e+++k+
  EFC37023.1  6 EDEISNLNQQINAETSVALSVQKRADFLHDQCKLFESLKEEEIKQ 50
                578888888999999999999999999988888888887887776 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.0004
   kleA_kleC  34 eeLvrqaeeLRakvyeesaaLedrakkrWtle 65 
                 + +++q+++LRak+ e+ + ++ +akk+  ++
  EFC37023.1  73 KTIEKQINDLRAKIQEQDSHIQKEAKKHQLIH 104
                 5689**********************997666 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.26
   kleA_kleC  22 rRdkiAaklaeAeeLvrqaeeLRakvyeesaaLedrakk 60 
                 +   +A+kl+e eeL+  + ++  +  +  +  + +++k
  EFC37023.1 145 HQTSMAEKLQEREELELAISQMQDELQTLTSETNTQIQK 183
                 556799999999999988888877776666666555555 PP

>> FUSC  Fusaric acid resistance protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.0    0.0014       1.9     219     308 ..      14     108 ..       6     116 .. 0.80
   2 ?    0.6   1.5      0.11   1.5e+02     585     638 ..     131     186 ..     115     197 .. 0.64

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0014
        FUSC 219 ralrrllsrmlallallsslarllarlraeeaaavpelaallaelaal.....eaaaaaealeaalaalrarlralrraleadadtaalllarla 308
                 +++++ +s  l++  +++ l+++ +   + ++++ ++ ++ ++e+ ++     ++ ++ +++e++++ lra++++++++ +++a  ++l+ ++ +
  EFC37023.1  14 QQINAETSVALSVQKRADFLHDQCKLFESLKEEEIKQYQKHIQEVNDFftsetSEGKQIKTIEKQINDLRAKIQEQDSHIQKEAKKHQLIHSEIQ 108
                 555566666677778888899999888888888866677777777777***9988899***********************99998888877665 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.11
        FUSC 585 araaldavlaalafrapaaarsarrlrapaaalraldaalaalaaseatsa..lrr 638
                   +  +++ +++ + + ++a++ ++++ ++ a+ ++++ l++l+++++t+   +++
  EFC37023.1 131 KEQKEKQIRSQIDYHQTSMAEKLQEREELELAISQMQDELQTLTSETNTQIqkRDA 186
                 33333444444446667777777777888888888888888888888777654444 PP

>> DUF2894  Protein of unknown function (DUF2894)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   8.0   0.00022      0.31      40     139 ..      42     142 ..      23     147 .. 0.70
   2 ?   -0.7   0.1       1.3   1.7e+03      42      59 ..     159     176 ..     139     196 .. 0.44

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00022
     DUF2894  40 aklaalldayaarleraekaaaealaeaaakapaaspstLaaLlaqiakrasaakeaaaaee...aaaaPaatveateelkaleyfretwsklstekql 135
                 +  ++ +++y++++++ ++  +++++e ++ +  ++   +++L a+i+++ s+ +++a +++   ++ ++++++ ++ee k  ++f+++++k + ekq+
  EFC37023.1  42 SLKEEEIKQYQKHIQEVNDFFTSETSEGKQIKTIEK--QINDLRAKIQEQDSHIQKEAKKHQlihSEIQTVSNNIKKEEKKKQDHFKQQQQKEQKEKQI 138
                 444678999999999998777776666666665544..489999999999444444444443222455558899999********************** PP

     DUF2894 136 rqsl 139
                 r  +
  EFC37023.1 139 RSQI 142
                 9876 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.3
     DUF2894  42 laalldayaarleraeka 59 
                 l+ ++++ +++l++ +++
  EFC37023.1 159 LELAISQMQDELQTLTSE 176
                 333334444433333222 PP

>> Baculo_IE-1  Baculovirus immediate-early protein (IE-0)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   2.7   0.00042      0.57      20      97 ..      51     126 ..      47     131 .. 0.89
   2 ?    0.9   0.4       0.3   4.1e+02      41      82 ..     142     183 ..     127     197 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00042
  Baculo_IE-1  20 ylkqlrkilklfvndycckklvkklkaaldelleeseksleviklinervqvlnvflekklyqcnicedtsaeerflk 97 
                  y k+++++++ f+ ++   k +k++++++++l ++ +++ ++i++  ++ q++   +e +    ni ++  +++ ++k
   EFC37023.1  51 YQKHIQEVNDFFTSETSEGKQIKTIEKQINDLRAKIQEQDSHIQKEAKKHQLIH--SEIQTVSNNIKKEEKKKQDHFK 126
                  899***********************************************9975..6777788888888887777776 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.3
  Baculo_IE-1  41 vkklkaaldelleeseksleviklinervqvlnvflekklyq 82 
                  +   ++++ e l+e e+   +i ++++++q l+  +++++ +
   EFC37023.1 142 IDYHQTSMAEKLQEREELELAISQMQDELQTLTSETNTQIQK 183
                  455566666777777777777777777777777777776654 PP

>> Lebercilin  Ciliary protein causing Leber congenital amaurosis disease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   1.3     0.029        40     146     188 ..       4      45 ..       1      50 [. 0.82
   2 ?    4.1  35.5     0.023        32       9     139 ..      44     176 ..      42     197 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.029
  Lebercilin 146 kleleeksfrrqlaaekkktkeaqeevkalqeeierlkqklke 188
                 kle e ++ ++q++ae++ +  +q++ + l+++++ +++ lke
  EFC37023.1   4 KLEDEISNLNQQINAETSVALSVQKRADFLHDQCKLFES-LKE 45 
                 567778899999999999999999999999999988776.444 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.023
  Lebercilin   9 rllkikeLqnelaelqskleelrkEnklLkrlqkrqekaLskyedteaeLpqllarhn...eEvrvlrerlRksqekerelekklkekeaellrlkdkl 104
                 ++++ik+ q+ ++e++      + E k +k++ k  +    k +++++++++  ++h+   +E++++ ++++k ++k ++  k+ ++ke++ +++++++
  EFC37023.1  44 KEEEIKQYQKHIQEVNDFFTSETSEGKQIKTIEKQINDLRAKIQEQDSHIQKEAKKHQlihSEIQTVSNNIKKEEKKKQDHFKQQQQKEQKEKQIRSQI 142
                 7899****************************987777778***************965559*********************************9999 PP

  Lebercilin 105 kklkkLsedknLaereeLqkkLeeleakleekeek 139
                 + +++ s++ +L+ereeL+  +++++++l++ + +
  EFC37023.1 143 D-YHQTSMAEKLQEREELELAISQMQDELQTLTSE 176
                 5.8999***********************986554 PP

>> Hydrolase_6  Haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.6   2.2e+03      52      52 ..      49      49 ..       8      78 .. 0.61
   2 ?    4.4   3.6      0.03        41      30      67 ..      97     141 ..      47     175 .. 0.66
   3 ?    3.8   0.1     0.044        61      22      55 ..     162     195 ..     157     198 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.6
                 H CS
  Hydrolase_6 52 e 52
                 +
   EFC37023.1 49 K 49
                 2 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.03
                  T.......-EEEEEE---SS-HHHHHHHHHHTT----GGGEEEHH CS
  Hydrolase_6  30 g.......kpvvllTNnsskseeeyakkleklgvditeeqvvtsa 67 
                           ++  ++Nn +k e++ ++++++ + + ++e+ + s 
   EFC37023.1  97 AkkhqlihSEIQTVSNNIKKEEKKKQDHFKQQQQKEQKEKQIRSQ 141
                  05555555667789***************8888877776666553 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.044
                  HHHHHHHTT-EEEEEE---SS-HHHHHHHHHHTT CS
  Hydrolase_6  22 alnalraagkpvvllTNnsskseeeyakkleklg 55 
                  a+ +++++  ++   TN   +++++++kkl++l+
   EFC37023.1 162 AISQMQDELQTLTSETNTQIQKRDAFCKKLKQLE 195
                  788888888899999****************986 PP

>> ApoO  Apolipoprotein O
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   7.3     0.044        60       6      56 ..      65     125 ..       2     144 .. 0.83
   2 ?    4.0   1.9     0.033        45      23      65 ..     155     198 ..     126     200 .] 0.80

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.044
        ApoO   6 rtpseeptdrLeegvrslRkslepytsavqdel..........nkvkskvetaeqsvtdti 56 
                 +t++ ++ +++e++++ lR  ++++ s +q+e           ++v++ ++++e++ +d +
  EFC37023.1  65 ETSEGKQIKTIEKQINDLRAKIQEQDSHIQKEAkkhqlihseiQTVSNNIKKEEKKKQDHF 125
                 4555688999********************9995555555555555555555555555554 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.033
        ApoO  23 lRkslepytsavqdelnkvkskvetaeqsvtdtiasLkepp.ed 65 
                  R++le  +s++qdel++++s  +t  q+    ++ Lk+ + ed
  EFC37023.1 155 EREELELAISQMQDELQTLTSETNTQIQKRDAFCKKLKQLEnED 198
                 49999999999999999999999999999888888887755455 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5728  (0.319482); expected 358.6 (0.02)
Passed bias filter:                      815  (0.0454571); expected 358.6 (0.02)
Passed Vit filter:                       255  (0.0142228); expected 17.9 (0.001)
Passed Fwd filter:                        91  (0.00507558); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 1.42u 0.42s 00:00:01.84 Elapsed: 00:00:00.60
# Mc/sec: 1011.73
//
Query:       EFC37024.1  [L=1070]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.5e-16   58.0   2.9    8.5e-16   58.0   2.9    1.7  2  D123           D123
    1.2e-08   35.0   0.2     0.0003   20.5   0.0    3.1  3  Abhydrolase_1  alpha/beta hydrolase fold
    4.9e-07   29.8   0.0    1.1e-06   28.7   0.0    1.6  1  Abhydrolase_4  TAP-like protein
     0.0018   17.6   0.0      0.049   12.9   0.0    3.1  4  Hydrolase_4    Serine aminopeptidase, S33
  ------ inclusion threshold ------
      0.013   15.5   0.0      0.026   14.5   0.0    1.4  1  R2K_3          ATP-grasp domain, R2K clade family 3
       0.02   14.8   0.0      0.052   13.4   0.0    1.6  1  R2K_2          ATP-grasp domain, R2K clade family 2
       0.11   12.0   0.0       0.28   10.6   0.0    1.6  1  Peptidase_S9   Prolyl oligopeptidase family
       0.15   12.7   0.0        3.7    8.1   0.0    2.4  1  Abhydrolase_6  Alpha/beta hydrolase family


Domain annotation for each model (and alignments):
>> D123  D123
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       1.3   2.9e+03      70     103 ..     123     160 ..      69     167 .. 0.49
   2 !   58.0   2.9   3.8e-19   8.5e-16     111     281 ..     202     407 ..     195     424 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.3
                 --...HHHHHHHHHHH....HHTTS-EEEE-SS---GG CS
        D123  70 pseefpeleekikeai....eelggavfpKlnwsaPkD 103
                  +e+ ++l ++i+e      ee  +  f Kl   +PkD
  EFC37024.1 123 LDENIQKLMHEIDECSlwkdEERREPLFFKLSSRSPKD 160
                 33444444444444321111233344566666666666 PP

  == domain 2  score: 58.0 bits;  conditional E-value: 3.8e-19
                 SS.S-BSSHHHHHHHHHT-HHHHHHHHHTTTTBT--TTS-S-TT----EEEEE--.---GGGEEEEEEETTEEEEEEESSS.S--THHHHTHHHHHHHH CS
        D123 111 ns.lkctsvndvylLLksSdfiahDLehafdeceeeeeesekeeieleLvLrkwf.dlnpslefRcFVkdrkLiaisqRdl.nyydfleelkeelkeki 206
                 ++ lk++s ++v+ LL  S+ ++ DL +++ e        ++++   +++Lr+w  +++  lefR F+ + kL aisq +   + + +e+ ++++++ i
  EFC37024.1 202 TEfLKISSSDEVLELLLRSSRVNMDLIETYVEF------WNEKSPLNKIALRRWDtTIDIRLEFRTFIVNGKLAAISQYNHfVHVEEIEQYHNQIQQLI 294
                 3349********988888889*****9999777......3333445679*****879*********************988899999999999999999 PP

                 HH...HHHT..TTTSSSSSEEEEEEEETT....................EEEEEEEEESSTTS--TTS-HHHHH......................HS- CS
        D123 207 ee...ffeeklkekfpdesyvfDvyvpkk..................ldkvkliDinpfaertdslLFtweeLl.................eeeeeeee 267
                 e+   +++e+l +++  +++v D  +  +                   d +kli +np++e+t ++LF+w+  +                  +++++++
  EFC37024.1 295 EKsvkYLKENLDKHMIFKHMVADFVIYPRffsdiektnqwnedliptGDYIKLIELNPYEESTGACLFSWKTDQqiipmpppqqieeesvnLNSDKSTS 393
                 862226678888888888999999998889999*************99**********************98777889999999999998766777778 PP

                 TTSSS-EEE----X CS
        D123 268 eeeeepelrlvese 281
                 ++++ +++r++++e
  EFC37024.1 394 DSTTGVNFRFITRE 407
                 88889999999655 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   1.4e-07    0.0003      14      92 ..     579     689 ..     572     698 .. 0.80
   2 ?   -1.3   0.0      0.62   1.4e+03      81      94 ..     715     728 ..     714     732 .. 0.84
   3 !   10.5   0.0   0.00015      0.34     199     256 ..     902     957 ..     860     958 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.4e-07
                    GGGTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB..................................CHHSHHHHHHHHHHH.HHHCTTSSE CS
  Abhydrolase_1  14 dvwaerglapaLakdgfdvillDlrGvgySspapacin.................................ddygtasvaddldri.ldalgddkl 75 
                    +v +e  l++ L  ++fd+++lD rG+g+Ss+  +  +                                 + y+ ++va d+ ++ +    +++ 
     EFC37024.1 579 EVSIE--LVSKLLGSDFDIYTLDTRGNGRSSRLGCDASqaetpgssggisisssewkncysafdaeygaqkQFYSSVNVAYDIAALiQKMNTQQET 672
                    45666..88889999********************999999988888888888777777766665555555445**********773666677777 PP

                    EEEEETHHHHHHHHHHH CS
  Abhydrolase_1  76 tlvGhSmGGmialayaa 92 
                    ++ G  +G+++++ ++ 
     EFC37024.1 673 YVYGLGYGSLVVSRLLK 689
                    7********99998875 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.62
                    THHHHHHHHHHHHH CS
  Abhydrolase_1  81 SmGGmialayaaey 94 
                    S+GG++al ya e 
     EFC37024.1 715 SYGGLLALSYADEI 728
                    9**********875 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.00015
                    HHHHHHHCTHHHHS..EEEEEEETTCSSSCH.HHHHHHHHC.HTSEEEEEEETCSSSHHHHS CS
  Abhydrolase_1 199 klllrlrelknvla..ptlvisgtsDplvpp.kaledlaql.lpkkrlvvisdagHlafleg 256
                    +++++      ++   ptl+i g+ D  +p  +a+ +l++   p   l++++++gH+ f++g
     EFC37024.1 902 NFYNK-----TITTtvPTLLINGEFDAETPLwSAQNQLKAIqGP-RALITVPKTGHMTFFDG 957
                    33333.....333345***********************99544.59*************97 PP

>> Abhydrolase_4  TAP-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.0   4.9e-10   1.1e-06      15      81 ..     891     959 ..     876     989 .. 0.76

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 4.9e-10
  Abhydrolase_4  15 Cagw.pvspqrprdestakgaapvLllqnerDpaTPyegakklakalgg.avlvtvegeGHgalaagnt 81 
                       w p++ +++  ++t ++++p+Ll+++e D+ TP+++a++  ka++g  +l+tv ++GH ++ +g++
     EFC37024.1 891 ITSWtPYTVNANFYNKTITTTVPTLLINGEFDAETPLWSAQNQLKAIQGpRALITVPKTGHMTFFDGSA 959
                    455645555555556666778***************************9779**********9987664 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.6   3.7e+03      47      71 ..     275     299 ..     272     310 .. 0.82
   2 !   12.9   0.0   2.2e-05     0.049      22      98 ..     583     692 ..     575     706 .. 0.83
   3 ?   -3.4   0.0       2.1   4.7e+03      84      97 ..     715     728 ..     714     732 .. 0.82
   4 ?    0.1   0.0      0.18   3.9e+02     190     237 ..     910     956 ..     898     958 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.6
  Hydrolase_4  47 gkrghvpsfddyvdDlaafvekvke 71 
                  ++ +hv+++++y + +++++ek ++
   EFC37024.1 275 NHFVHVEEIEQYHNQIQQLIEKSVK 299
                  5788999999999999999998764 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 2.2e-05
  Hydrolase_4  22 elaeaLaaqGfavyalDhrGhGrse.................................gkrghvpsfddyvdDlaafvekvkeehpelplfllGhSmG 86 
                  el+ +L   +f++y+lD rG Grs                                   + g +++f + v+ +  +   +++ + +++ +++G   G
   EFC37024.1 583 ELVSKLLGSDFDIYTLDTRGNGRSSrlgcdasqaetpgssggisisssewkncysafdAEYGAQKQFYSSVNVAYDIAALIQKMNTQQETYVYGLGYG 680
                  78999********************9999999999999999999999999999999997777777777777766666666777778888899999999 PP

  Hydrolase_4  87 Gliallyllryp 98 
                  +l++ ++l+  +
   EFC37024.1 681 SLVVSRLLKLVE 692
                  999999885444 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 2.1
  Hydrolase_4  84 SmGGliallyllry 97 
                  S GGl+al+y+++ 
   EFC37024.1 715 SYGGLLALSYADEI 728
                  99********9775 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.18
  Hydrolase_4 190 itlPllllhGeaDkvvdpeasrelyerlgskdktlklypglyHellnE 237
                   t+P+ll+ Ge D  ++   +++ +++++     l + p+  H+++++
   EFC37024.1 910 TTVPTLLINGEFDAETPLWSAQNQLKAIQG-PRALITVPKTGHMTFFD 956
                  46***********99999998888888886.78899999999999987 PP

>> R2K_3  ATP-grasp domain, R2K clade family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   1.2e-05     0.026     113     158 ..     253     294 ..     192     302 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.2e-05
       R2K_3 113 vrfsaEwRvFvvdGevvaasrYrkanddpdlepdlaafaeavralv 158
                 +++  E+R+F+v+G++ a+s+Y      + + ++++ + +++++l 
  EFC37024.1 253 IDIRLEFRTFIVNGKLAAISQYN----HFVHVEEIEQYHNQIQQLI 294
                 37789*****************4....4444456666666666654 PP

>> R2K_2  ATP-grasp domain, R2K clade family 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   2.3e-05     0.052      61     100 ..     253     295 ..     249     323 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.3e-05
       R2K_2  61 vsfasEyRlfvldgeiitvsrYagegrl.dpdp..evaeeava 100
                 ++++ E+R f+++g+++++s+Y+   ++ ++++  + ++++++
  EFC37024.1 253 IDIRLEFRTFIVNGKLAAISQYNHFVHVeEIEQyhNQIQQLIE 295
                 67889*******************9999533334433333333 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00013      0.28     121     186 ..     884     951 ..     865     976 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00013
                   TTTCHHHHHHHHHH-CGGG--.....---EEEEEEETT-SSS-THHHHHHHHHHH--S-SEEEEEETTS-S CS
  Peptidase_S9 121 peeneegykelspyspldnvk.....aypplLlihGlaDdrvppaealklvaaLqkkgknvlllifpdegH 186
                    + n ++   + py+  +n+       ++p+Lli G+ D  +p+++a   ++a q    +  l + p+ gH
    EFC37024.1 884 YWANLKEITSWTPYTVNANFYnktitTTVPTLLINGEFDAETPLWSAQNQLKAIQG---PRALITVPKTGH 951
                   455666666667776666655888999********************998888875...556777888888 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.0    0.0017       3.7      21     211 ..     587     955 ..     566     961 .. 0.44

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0017
                    HHHCCTCEEEEE--TTSTS-GGCS.......................................--HHH.CHHHHHHHCCTT..TTSE..EEEEETC CS
  Abhydrolase_6  21 allaagvhvlapDlpGhGrsdppp.......................................ldled.ladlaalldelaagggpv..vlvGHSl 74 
                    +ll++++ ++++D +G+Grs++                                         ++  + + d+aal+++      +   ++ G  +
     EFC37024.1 587 KLLGSDFDIYTLDTRGNGRSSRLGcdasqaetpgssggisisssewkncysafdaeygaqkqfYSSVNvAYDIAALIQKMN---TQQetYVYGLGY 679
                    566666666788888887552222222222222233333333333333333333333333222111111344466666663...333457777777 PP

                    HHHHHHHHHHCC........EEEEES-...................................................................-- CS
  Abhydrolase_6  75 GGalalaaapla......lvvgvlldp.........................................................pp........ta 99 
                    G ++++++++l       ++ g +ld+                                                          +         a
     EFC37024.1 680 GSLVVSRLLKLVeqnglnILKGSILDSiidttgqnsyggllalsyadeitnqvgieflklcngtdnlcaqkignvdpikyfhdtIEkvyhnntcKA 775
                    777777744444666766555566665444455555555555555555555555555555555555554454444433333322002222332222 PP

                    --TTTS----TTHHHHHHTT-C.....CCCHCCH......S-HSCCCCHHHCCCCHCHCCCGHH................................ CS
  Abhydrolase_6 100 lpagllaaalelllallallrl.....lawlsre......plprlfladedadaawrarlarla................................ 152
                       g +a+ ++ +la+l l  +     +a+l r+      ++  ++l+  d+++a                                         
     EFC37024.1 776 IKEGIPADQFKAILAFLLLGSDtkvfiPALLYRMnrcdedLDVATILHIRDYYVAQ-------Kaafsnltsiplasplatanlifgelynseisl 864
                    22222222222222222222221111211111111122221111222222211111.......012222334545555556666666666666666 PP

                    ..................HHCCHHCHTTCCHHTT-TTGC...................EEE.C...TT-CHHHHCHHCCCH..STTEEETCE...S CS
  Abhydrolase_6 153 ..................allaglgllpaaawadlpvpl...................lvl.g...geDplvprllerlla..qagarlpvvlpga 205
                                            +   +a+++ +++++                   l++ g   +e pl+   ++  l   q  + l +++p +
     EFC37024.1 865 eelkvqynnftsiglgdsV-----Y---WANLKEITSWTpytvnanfynktitttvptLLInGefdAETPLWS--AQNQLKaiQGPRAL-ITVPKT 949
                    6665544444333222220.....1...556666666666555556556666555555666752234444555..55555566677777.999999 PP

                    SS-HHH CS
  Abhydrolase_6 206 GHlphl 211
                    GH+ ++
     EFC37024.1 950 GHMTFF 955
                    998777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1070 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1535  (0.0856155); expected 358.6 (0.02)
Passed bias filter:                      674  (0.0375927); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.96u 0.32s 00:00:01.28 Elapsed: 00:00:00.52
# Mc/sec: 6234.04
//
Query:       EFC37025.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.9e-45  154.7   0.4    8.8e-45  153.1   0.4    1.7  1  Dyp_perox  Dyp-type peroxidase family


Domain annotation for each model (and alignments):
>> Dyp_perox  Dyp-type peroxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.1   0.4   4.9e-49   8.8e-45       1     324 [.      32     348 ..      32     351 .. 0.74

  Alignments for each domain:
  == domain 1  score: 153.1 bits;  conditional E-value: 4.9e-49
                 BSSSSS-C-SEEEEEEEEE-TTCHHHH.HHH....HHHHHHHHHHHHHCCCCSCSSHCTCCCTHSTTTT-EEEEEEEHHHHHHTTSCGGS-TTCS---- CS
   Dyp_perox   1 qagiltplqaaaifvaldvkakdkakl.eal....lrkltarverLtagekappadtgealkarkpdsrLtvtvgiGsslfdrlglkekrpkeLkplpe 94 
                 q+ iltp+++ a fv +++k++ k++   ++    ++ + a ++ +++ +k   +   + ++++  +s L+ +   + +  ++  ++e  p+  k+l+ 
  EFC37025.1  32 QSTILTPISDHACFVTIELKDELKSSSnGKAmkiyFKLVEACLQIMERWNKEKCTQFAVGFGYELTNSILGNIQDNSLDYVREYMQAEIFPQYPKDLK- 129
                 67788888888888888887765544333330000444444444444443332222222222322333333333333333333333333333333333. PP

                 ETTTTEEGGGS--SEEEEEEESSHHHHHHHHHHHHHH..HTTTE.EEEEEEEEEEEHC..TSTTCB-TTSSBSSTTS--TCHHHHHHHS-CSSSGGGTT CS
   Dyp_perox  95 lkndkldapstdgDlliqiraeredvafealrailka..fgdav.evrdevkGFrsss..gkvtarnLlGFvDGTeNpkgeeakeavvlikdedewaag 188
                   ++    p t+gDl+++i++ ++d +f a ++ +++  +   + +++de+  F   +  ++   r+L GF DGTeNpk+ e+k + ++  +e      
  EFC37025.1 130 --GKFGGFPNTGGDLFLHIKSVNMDNCFRATQDFANHefISPLIkKIQDETYAFLHRRnkKSGLGRDLSGFEDGTENPKEMEEKIE-ATLTNE-----K 220
                 ..22233589************************9983323334379*******98774455668******************998.555555.....4 PP

                 -EEEEEEEEEE-HHHHTTS-HHHHHHHHTB-TTT--BTTTTSTTSTTTGSSS-TTSHHHHHSGESTTTEC--EE--EEEEEEE-TTSSCEEEEEEEEEE CS
   Dyp_perox 189 GsYvvvrkirhdleaWdrlslkeQedviGRrKedgaeldddkeaddseekvipkdsHvrlaklkedgkglkilRralsygeGldkvgkldaGllFiaYq 287
                  s+++ +k+ h+l+++++lslkeQe+ iGR+Ked++el+           ++p++sHv++++l++dg + +++R+++s+g+    ++  ++Gl+Fi+Y+
  EFC37025.1 221 DSFLLAQKWVHNLKFFNSLSLKEQENDIGRTKEDSIELE-----------NKPETSHVARVTLEKDGDEIEVVRQSMSFGN----SS--QHGLFFISYA 302
                 79************************************4...........56*****************************....55..7********* PP

                 SSCHHCHHHHHHHH.........SCB-GGGGCEEEEEEEEEEE-BH CS
   Dyp_perox 288 rtlenteqmlqrml.........gktdaLlefikavtgglFfapsg 324
                  + ++++++l++m          g++d++ +f++ + g+l+f ps 
  EFC37025.1 303 NSGKTFIHQLESMVgkgeyatpqGHNDHIMRFSTNILGSLYFIPSI 348
                 ********************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       672  (0.0374812); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2310.50
//
Query:       EFC37026.1  [L=857]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      3e-34  118.7   6.6      6e-34  117.8   6.6    1.4  1  G-alpha        G-protein alpha subunit
    2.4e-29  102.5   0.0    3.8e-29  101.9   0.0    1.3  1  Peptidase_M20  Peptidase family M20/M25/M40
    2.4e-12   46.7   0.0    6.5e-12   45.3   0.0    1.7  1  M20_dimer      Peptidase dimerisation domain
    1.8e-05   24.3   0.1    4.2e-05   23.1   0.1    1.6  1  Arf            ADP-ribosylation factor family
    0.00016   20.8   0.0    0.00039   19.6   0.0    1.6  2  Peptidase_M42  M42 glutamyl aminopeptidase
  ------ inclusion threshold ------
       0.12   12.0   0.9       0.27   10.9   0.2    1.9  2  Neuropep_like  Neuropeptide-like


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.8   6.6     2e-37     6e-34      69     350 ..       7     287 ..       2     291 .. 0.79

  Alignments for each domain:
  == domain 1  score: 117.8 bits;  conditional E-value: 2e-37
                 HHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH...........HHCCHHC-HCHHHHHHHHCCSHHHHHHHC...CGCCTT--TTHHHHH CS
     G-alpha  69 rsiktilealesleselsesfelqelkerldplkkveasliaklssateee.qeiefnpraevgedikaLwndpgiqelye...rrnkiklednaeyFl 163
                 ++++ ++  + +   +++e++ +qe++  l+++   e +l  +  +++ ++  e e+++ ++ +e ++ Lw+  +++e+ye   +r  i++ +n++ + 
  EFC37026.1   7 NNLQIVCSLVVE---RIWEEMGEQERNYLLKEIIRPEMRLLFESATDNASNcLEMELQK-IDCVEILVNLWKISFFREFYElvwSRGGISMYENVKELV 101
                 555555555555...7888999****************998766666555577777777.9********************99877799999*****97 PP

                 CTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCC CS
     G-alpha 164 ddleritspdYlptddDilkarlktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeic 262
                  ++er   + + p    ++ +   + Gis ++   ++++e++++dv G+r+ rk W++ff+dv +++++vslsef+q+ +ed++v+r++esl+l  e++
  EFC37026.1 102 LRIERG--KIFSP--YSLISST--SKGISIYETITRRNTEIQVIDVVGRRNSRKIWIHFFEDVHTLVYMVSLSEFNQTIMEDDSVQRMDESLSLIGEVM 194
                 777754..34556..7778887..55666666666889************************************************************* PP

                 C-GGGTTSEEEEEEE-HHHHHHHCCCS.-GGG.CCTT--.......H.CCHHHHHHHHHH.HHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHH CS
     G-alpha 263 nnkllkntpiiLflnKlDileeKlkkg.klsk.yfpsye.......grkndlesvlkylr.nkFeeihkeksnnrrkiythftsatdtkevqkviesv 350
                 n +++  ++ i+++ K+Dil +Kl++g k  + +++++          ++ l+ v++ ++ + F++i     +++    +h+++at ++++++v + +
  EFC37026.1 195 NTRWFIPSRKIILFVKPDILCKKLENGvKYDReLVSNILpelerseIANHYLKLVINSIItQYFKKI-----DRNTLDSYHIVNATSEDDIKSVSDII 287
                 ************************9999887765544442222433223345555555552444444.....333345799************98876 PP

>> Peptidase_M20  Peptidase family M20/M25/M40
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.9   0.0   1.3e-32   3.8e-29       1     206 [.     474     847 ..     474     848 .. 0.89

  Alignments for each domain:
  == domain 1  score: 101.9 bits;  conditional E-value: 1.3e-32
                    EEEEES-BSS.TTCGGGSSS.TTSEEETTTEEESTTTTTTHHHHHHHHHHHHHHHHH..TTT-SSEEEEEEESTTSSTT.THHHHHHHHHHTTTCE CS
                    xxxxxxxxxx.xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxx RF
  Peptidase_M20   1 llgsHlDvVp.eeetdgwtt.pfslteedGklyGrGaddmkggvlaalealralkde..gikpkgtivllfqpdEEggr.gGakallegleerekv 91 
                    ll +H DvVp + ++++w++ pfs+++ +G+l+GrG+ d+k+gv  +leal +l++e   +kp+++  +++  dEE+g+  Ga++++  ++ +++v
     EFC37026.1 474 LLTGHVDVVPiN-DESKWEYpPFSGKQVNGFLHGRGTLDDKNGVYEILEALNQLRREnlLVKPQRDTYVVIGMDEEIGGvHGAAKVTSYFL-KKNV 567
                    689*******54.5559***************************************933468899***********9999********888.6788 PP

                    SEEEEEEEESSSBTCHSTETEEEE........................................................................ CS
                    xxxxxxxxxxxxxxxxxxxxxxxx........................................................................ RF
  Peptidase_M20  92 davfelhieepgileagklaigvv........................................................................ 115
                    +++f ++ e++ i + ++  +gv                                                                         
     EFC37026.1 568 RFAF-VLDEGGQIAD-QQ-FPGVAspiafvaiaekgycnfdiqancnpghasmpgrtscigtlskaileiennpmpahllkpiihnvllslaphse 660
                    8888.5556666666.44.677778999******************************************************************** PP

                    ...................................................................................EEEEEEE....EE CS
                    ...................................................................................xxxxxxx....xx RF
  Peptidase_M20 116 ...................................................................................kvevell....eg 124
                                                                                                       +++v++l    ++
     EFC37026.1 661 gyimkaivanldilayplsialsyiggppnalartsfaptivaagvqsnvmpskanfilntrfspydnlqsvkshlekvvnhpNITVTPLmidcQE 756
                    *********************************************************************************986888877775566 PP

                    ESHEEECCHHHHHHHHHHHHHHHTSCEEEEEES...SSBHTHHHHTTT.E.EEEE.....EE.SSG..GCTTSTTTEEEHHHHHHHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxx.x.xxxx.....xx.xxx..xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M20 125 gapvtlndsplvkalaeaaeelfgekvelivsg...pggtdarffagi.p.tvmi.....fg.pgs..glaHspnEyvdledlekgikvlarlle 206
                    + +v + d   ++++++a+  + +  +++ivs+   ++g+d++++ ++   ++ +     ++   +  +++H++nE++ ++++ + + v+ ++++
     EFC37026.1 757 ASSVSCVDCVEFEVVKRAINHI-Q--PDVIVSPylfIAGSDSKYYRKLsDfAY-GylpmrLVkKTEdlQRIHGHNERILIQNYLESVTVYSSIIL 847
                    6666666888899999999886.5..99999999***********77743333.22465555333259***********************9997 PP

>> M20_dimer  Peptidase dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.3   0.0   2.2e-15   6.5e-12       1     104 [.     596     743 ..     596     747 .. 0.98

  Alignments for each domain:
  == domain 1  score: 45.3 bits;  conditional E-value: 2.2e-15
                 SEB-EEEEEEEEEE-B-EEGG-TTTTB-HHHHHHHHHHCSCTTEEC..................................................TCC CS
   M20_dimer   1 ighkGlaggkitvkgkagHsgapgagaNAieklarllaeledeegdia.............................................eerslp 54 
                 i++kG++ + i ++ + gH+++pg+  + i  l++++ e+e+++ + +                                             +++ l+
  EFC37026.1 596 IAEKGYCNFDIQANCNPGHASMPGRT-SCIGTLSKAILEIENNPMPAHllkpiihnvllslaphsegyimkaivanldilayplsialsyiggPPNALA 693
                 689***********************.****************99988*************************************************** PP

                 TCCCCCEECCE-CCCCEESSEEEEEEEEEHHHHHHHHHHHHHHHHHHTSC CS
   M20_dimer  55 rttlnvtgiegGsaknvipdeaeakidiRllpgedpeevleeieeileke 104
                 rt++++t++ +G ++nv p++a + ++ R++p +++++v+  +e+++++ 
  EFC37026.1 694 RTSFAPTIVAAGVQSNVMPSKANFILNTRFSPYDNLQSVKSHLEKVVNHP 743
                 *********************************************99976 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.1   1.4e-08   4.2e-05      50      95 ..     126     171 ..     117     228 .. 0.86

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.4e-08
                 EEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT CS
         Arf  50 veeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre 95 
                  e+++ +n +++v Dv G+++ R++W ++fe++++++++v  ++ +
  EFC37026.1 126 YETITRRNTEIQVIDVVGRRNSRKIWIHFFEDVHTLVYMVSLSEFN 171
                 4899************************************877654 PP

>> Peptidase_M42  M42 glutamyl aminopeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0         2     6e+03       8      24 ..     465     481 ..     461     482 .. 0.73
   2 !   19.6   0.0   1.3e-07   0.00039     132     189 ..     509     574 ..     498     586 .. 0.76

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 2
                    ESSTTSSEEEEEEE--B CS
  Peptidase_M42   8 kgkekepkvmiaAHmDe 24 
                     + ++++ v++++H+D 
     EFC37026.1 465 GSDKEKKPVLLTGHVDV 481
                    445667789******96 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 1.3e-07
                    THHHHHHHHHHHHHHHHHCTSS-S....SEEEEEEESTCTTT..SHHHHHHHHHH..--SEEEEEE CS
  Peptidase_M42 132 alDdragvavllellkelkeeele....atvylvatvqEEvG..lrGaktsaeki..kpdiaiavD 189
                    +lDd+ gv+ +le+l++l++e+l      ++y+v+ + EE+G  +++ak+ ++ +  ++ +a+++D
     EFC37026.1 509 TLDDKNGVYEILEALNQLRRENLLvkpqRDTYVVIGMDEEIGgvHGAAKVTSYFLkkNVRFAFVLD 574
                    69*******************99766789************8644556655554411455566666 PP

>> Neuropep_like  Neuropeptide-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0         3   8.9e+03      15      36 ..     299     321 ..     298     323 .. 0.67
   2 ?   10.9   0.2     9e-05      0.27      11      31 ..     757     777 ..     754     781 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3
  Neuropep_like  15 PCvDChafefmqraLq.DLkkta 36 
                    PC+ C + ++   +L+  Lkk a
     EFC37026.1 299 PCIKCPSAQLSEHSLRfHLKKMA 321
                    99999877776666653566655 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 9e-05
  Neuropep_like  11 aesrPCvDChafefmqraLqD 31 
                    a s  CvDC  fe ++ra+  
     EFC37026.1 757 ASSVSCVDCVEFEVVKRAINH 777
                    78999*************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (857 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       935  (0.0521501); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.87u 0.40s 00:00:01.27 Elapsed: 00:00:00.59
# Mc/sec: 4356.70
//
Query:       EFC37027.1  [L=156]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-05   23.3   0.2     0.0001   22.4   0.2    1.6  1  Erf4      Golgin subfamily A member 7/ERF4 family
  ------ inclusion threshold ------
      0.029   14.8   0.3      0.036   14.5   0.3    1.1  1  MerC      MerC mercury resistance protein
       0.93    9.9   3.9         16    6.0   0.1    2.6  3  DUF3624   Protein of unknown function (DUF3624)


Domain annotation for each model (and alignments):
>> Erf4  Golgin subfamily A member 7/ERF4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.2   1.7e-08    0.0001      14      75 ..      11      73 ..       6     129 .. 0.88

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 1.7e-08
        Erf4 14 apqFstllppeLsgyiseeefeeiinkiNeilaeafspysvrnil.dnvlglltlylwslvlk 75
                a qF +++p++ s+++ +e+f++ +++iN+  ++   p+++++i   +++ + +l+l++ v+ 
  EFC37027.1 11 AKQFTSEFPSQFSSILAPETFDSHLEQINKCAIKHVGPITIQTISvSTLVTINSLALMAAVSG 73
                68****************************************996145566667777777766 PP

>> MerC  MerC mercury resistance protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.3     6e-06     0.036      33      85 ..      55     116 ..      42     146 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6e-06
        MerC  33 lasellhqvllilvvaigllalvvgyrrhrktsvlvlgalGllillvalflg.........t 85 
                 + s l+    l+l++a++++++++ y + +  +v  l+a+G+ +ll+a+ +          +
  EFC37027.1  55 SVSTLVTINSLALMAAVSGFSTLKKYDTSQPILVGSLLAIGISLLLIAHSIAlilmsikykQ 116
                 557778888999************************************99885555544441 PP

>> DUF3624  Protein of unknown function (DUF3624)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.1    0.0026        16      42      62 ..      57      77 ..      39      80 .. 0.86
   2 ?    4.6   0.4    0.0072        43      54      74 ..      91     111 ..      83     113 .. 0.83
   3 ?   -2.8   0.0       1.5   8.8e+03       7      15 ..     136     144 ..     134     145 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0026
     DUF3624 42 dtpksvesialllaafafsgL 62
                 t  +++s+al+ a+++fs+L
  EFC37027.1 57 STLVTINSLALMAAVSGFSTL 77
                67789*************998 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0072
     DUF3624  54 laafafsgLLllHlvvlayrk 74 
                 l a+++s+LL++H ++l++ +
  EFC37027.1  91 LLAIGISLLLIAHSIALILMS 111
                 678999*******99988765 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 1.5
     DUF3624   7 kesvfkkKl 15 
                 ++s+f +K+
  EFC37027.1 136 ENSWFSQKI 144
                 689999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       943  (0.0525964); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 914.18
//
Query:       EFC37028.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.087   12.6   0.0       0.79    9.6   0.0    2.5  2  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
       0.17   12.0   0.2       0.78    9.9   0.0    2.1  2  DUF5500   Family of unknown function (DUF5500)


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.14   1.3e+03      13      21 ..      52      60 ..      52      62 .. 0.87
   2 ?    9.6   0.0   8.8e-05      0.79       1      30 []     206     235 ..     206     235 .. 0.96

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.14
      RCC1_2 13 aLtedGeVl 21
                +L+e+G V+
  EFC37028.1 52 VLSESGQVY 60
                799*****9 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 8.8e-05
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +k++ +G++ ++++ ed++V+ +G+N++ Q
  EFC37028.1 206 IKKIECGSFQFFVIFEDDTVMFCGDNGSNQ 235
                 799***********************9988 PP

>> DUF5500  Family of unknown function (DUF5500)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   8.8e-05      0.78      24      59 ..     146     181 ..     135     192 .. 0.89
   2 ?   -2.0   0.0      0.42   3.8e+03      41      53 ..     328     340 ..     316     347 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 8.8e-05
     DUF5500  24 fltrrtrdgfcgrltsiatnshytmfvldhgsvrie 59 
                 + t  t +g+  ++t ia+   +t++vld+  +ri 
  EFC37028.1 146 LYTPPTVNGYRHQITHIASCYSFTIIVLDYCDIRIS 181
                 56778999**************************96 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.42
     DUF5500  41 atnshytmfvldh 53 
                  +nsh   fv+d 
  EFC37028.1 328 ISNSHNMRFVVDA 340
                 479***99**996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       572  (0.0319036); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.25s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 2791.75
//
Query:       EFC37029.1  [L=247]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.2e-05   23.4   1.3    4.9e-05   23.1   0.1    1.8  2  DSPc             Dual specificity phosphatase, catalytic doma
    9.9e-05   22.0   0.0    0.00014   21.5   0.0    1.2  1  Y_phosphatase    Protein-tyrosine phosphatase
    0.00016   21.4   0.1     0.0013   18.5   0.1    2.0  2  CDKN3            Cyclin-dependent kinase inhibitor 3 (CDKN3)
     0.0043   17.1   0.0     0.0058   16.6   0.0    1.3  1  Y_phosphatase3   Tyrosine phosphatase family
  ------ inclusion threshold ------
      0.068   13.3   0.0       0.12   12.5   0.0    1.3  1  PTPlike_phytase  Inositol hexakisphosphate
      0.074   12.6   0.2      0.074   12.6   0.2    2.1  2  Y_phosphatase2   Tyrosine phosphatase family


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1      0.75   2.2e+03      11      32 ..      20      41 ..      10      65 .. 0.58
   2 !   23.1   0.1   1.6e-08   4.9e-05      34     111 ..     126     210 ..      81     231 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.75
                HHHHHHHTCSEEEEESSSSSEC CS
        DSPc 11 lallsklgitlvinvtkevpna 32
                 +l+++l+i  ++n+ +e + +
  EFC37029.1 20 NNLNNNLNILNNLNIKEEYKLP 41
                4455666666666666665554 PP

  == domain 2  score: 23.1 bits;  conditional E-value: 1.6e-08
                 CCTTTTSEEEEECCES...STTSCCGGGHHHHHHHHHHHHHTT-EEEEEESSSSSHHHHHHHHHHHHHHTSCHHHHHHHH......H CS
        DSPc  34 alkkseieklripved...ehetkiskyleeavefidkakqkgkkvlVHCqaGisRSatliiaYlmktknlslneayefl......k 111
                  l+ +++++l++ + d   ++++k+ +++++  e + ++k+++ k+l+HC  G  R++t+    l   ++l++++a+e +      +
  EFC37029.1 126 NLNINNFTYLHLEIPDnyvTSDEKVMNFINQ--ELLPQIKKEESKCLIHCWGGHGRTGTISSILLSHLYQLNSQQALERVakvhscR 210
                 4455677777777777345556666666654..778899**********************99999999******999995555551 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.0   4.8e-08   0.00014     153     217 ..     148     217 ..     124     231 .. 0.64

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 4.8e-08
                    HHHHHHHHHHHHHH....STTSS-EEEECSSSSHHHHHHHHHHH.HHHHHHHHSE...EEHHHHHHHHHTTST CS
  Y_phosphatase 153 ksllklirkveksk....eaksgpvvVhCsaGvgRtgtfvaldi.llqqleaeee...vdvlqivkelrkqRp 217
                    ++++++i++         +++++ +++hC  G gRtgt+ ++ +  l ql++++    v  ++ ++ +rk+R+
     EFC37029.1 148 EKVMNFINQE---LlpqiKKEESKCLIHCWGGHGRTGTISSILLsHLYQLNSQQAlerVAKVHSCRIIRKSRA 217
                    3344444332...222245667****************98765414566666555556666667777777774 PP

>> CDKN3  Cyclin-dependent kinase inhibitor 3 (CDKN3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.13     4e+02      21      44 ..      80     103 ..      71     109 .. 0.83
   2 !   18.5   0.1   4.3e-07    0.0013     105     161 ..     136     194 ..     118     200 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.13
                 XXBTS----EEEE-GGGT-SSEEE CS
       CDKN3  21 eeeqtpiqiswlslsrvncsqflg 44 
                 + e++ i+is l  s +nc   l 
  EFC37029.1  80 NLEKSKIKISQLLKSGINCFVCLQ 103
                 568999*************77665 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 4.3e-07
                 E----TTS.---HHHHHHHHHHHH.HHHHTT--EEEE-SSSSSHHHHHHHHHHHHH-SS CS
       CDKN3 105 hhpiadgg.tpdiascleimeela.tclknyrktlihcygglgrsclvaaclllylsds 161
                 h  i+d   t d      i +el     k++ k lihc+gg gr+  +++ ll +l + 
  EFC37029.1 136 HLEIPDNYvTSDEKVMNFINQELLpQIKKEESKCLIHCWGGHGRTGTISSILLSHLYQL 194
                 55666654155555555566676515567789***************999999887653 PP

>> Y_phosphatase3  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   1.9e-06    0.0058     112     144 ..     157     190 ..      88     198 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.9e-06
  Y_phosphatase3 112 kvfealadee.pvlfHCtaGKDRTGvlaalllsl 144
                     +++ ++ +ee  +l+HC  G  RTG ++ +lls 
      EFC37029.1 157 ELLPQIKKEEsKCLIHCWGGHGRTGTISSILLSH 190
                     566677775579****************999986 PP

>> PTPlike_phytase  Inositol hexakisphosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0     4e-05      0.12      99     150 ..     131     185 ..     125     188 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4e-05
                      T-EEEEEEE-TTS---HHHHHHHHH..HHHTS.-TT-EEEEE-SSSSHHHHHHHH CS
  PTPlike_phytase  99 slrYaRipitdekapeeedfdalvs..ilkea.pektalvfnCqmGrgRTTtamv 150
                      +++Y  + i+d++  ++e++  +++  +l +  +e++ ++++C  G gRT t   
       EFC37029.1 131 NFTYLHLEIPDNYVTSDEKVMNFINqeLLPQIkKEESKCLIHCWGGHGRTGTISS 185
                      67899999************99996324555545599*************99765 PP

>> Y_phosphatase2  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.3      0.32   9.6e+02      22      39 ..      23      40 ..      11      50 .. 0.77
   2 ?   12.6   0.2   2.5e-05     0.074      51     112 ..     126     187 ..      97     201 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.32
                    HHHHHHHHHCT-SEEEE- CS
  Y_phosphatase2 22 asnfsflksLkLktiisl 39
                    ++n++ l++L++k++ +l
      EFC37029.1 23 NNNLNILNNLNIKEEYKL 40
                    578888999999998765 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 2.5e-05
                     HHHHCT-EEEE-------GGG----HHHHHHHHHHHH-GGG-SEEEE-SSSSSHHHHHHHHH CS
  Y_phosphatase2  51 fleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckrGkhrtglvigcl 112
                      l+ ++  ++h++i++n  +  e + + +++ l   + ke+  +l+hc  G+ rtg++  +l
      EFC37029.1 126 NLNINNFTYLHLEIPDNYVTSDEKVMNFINQELLPQIKKEESKCLIHCWGGHGRTGTISSIL 187
                     3445666788999999999899999999999999999*******************998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (247 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1651.08
//
Query:       EFC37030.1  [L=414]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.4e-41  141.7   0.3    8.4e-41  140.4   0.3    1.6  1  Peptidase_S58  Peptidase family S58
  ------ inclusion threshold ------
       0.13   12.3   0.0       0.27   11.2   0.0    1.4  1  F-box-like_2   F-box-like domain


Domain annotation for each model (and alignments):
>> Peptidase_S58  Peptidase family S58
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  140.4   0.3   9.4e-45   8.4e-41       4     292 ..       7     395 ..       5     398 .. 0.85

  Alignments for each domain:
  == domain 1  score: 140.4 bits;  conditional E-value: 9.4e-45
  Peptidase_S58   4 tDVaGvrVghatlaegevrtGvTvilprgnlfkekvvAavdvlnGfgkttgtdqleelglle..tpivLtntlsvg.aaadgvvewlleeeee.ee 95 
                    t ++G+ Vgh++      ++G+Tv+l +     e +  +vd+++G+ +t++td+l++  l+e  +  v+++++++g +a +gv+++  e+    ++
     EFC37030.1   7 TSIEGIIVGHCNE----GNSGCTVVLSE---NSEGFGCGVDCRGGATGTRETDLLKPGMLVEkiHGCVISGGSAFGlDASSGVMKYFREKGIGyHT 95 
                    889********96....59********9...4566899***************************************************7555567 PP

  Peptidase_S58  96 arsvvpvVaetnDgvlndiragavkeehvaeala........aAaaapvae................................GnvGaGtGmiafg 151
                    +   vp+V +   +vl+d++  + k+++ ++  +        +       +                                Gn+GaG G ++++
     EFC37030.1  96 DILNVPIVCQ---AVLYDLQMLNKKDNTSLSLSSndnnnnntS-------StsnnqnnsiidlpnyfelgykacknpisndinGNIGAGNGSTIGK 181
                    77789*****...*******99966665444443444443220.......122334555666666777777888888888999***********99 PP

  Peptidase_S58 152 l.......KGGiGtaSrvleegekeytvgalvqaNfggr.........edlriagvpvgkelaeea.............................. 201
                    l       KGG+G    +++   +e+ +ga+v++N  g                 ++++      +                              
     EFC37030.1 182 LlgakhsmKGGLGCYAIQVD---NELKIGAMVAVNCFGDvyengnliaG-----CYKIN------Dvdstsdstttntsllsdstistnntddtsf 263
                    89999999***********6...459***********997776433332.....22222......1223335667778999999999999****** PP

  Peptidase_S58 202 .............................................kdgsiivvvatDapLskrqlkrlakraalGlartgsp.hsngsGDivlafs 251
                                                                  ++++i +v ++  L+k ql+r+a++a++G ar ++p h+  +GD+++++s
     EFC37030.1 264 nsnnfnnssndklvefldsekilikeylqskeeanafelskrkhdITNTTIGIVVCNGILDKSQLNRIAMMAHDGYARSMKPsHTLYDGDTIFVIS 359
                    ********************************************999************************************************* PP

  Peptidase_S58 252 taekepeevledeeldelfeaaaeaveeAilnallaAetvt 292
                    t++ + +        + + + aa++ve+A++n++ +A++++
     EFC37030.1 360 TGTINVKP-----PTNLIGTLAAQVVEKAVVNGVKHAQSMN 395
                    **988774.....58999********************997 PP

>> F-box-like_2  F-box-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   3.1e-05      0.27      10      49 ..     133     171 ..     125     175 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 3.1e-05
  F-box-like_2  10 atnaapkfrsltllDlPdellelifkgCkdpayeplspsl 49 
                    t +  ++++ +++DlP++ +el +k Ck+p++ +++  +
    EFC37030.1 133 NTSSTSNNQNNSIIDLPNY-FELGYKACKNPISNDINGNI 171
                   56778899*********98.8***********99987666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (414 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1131  (0.0630822); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2414.37
//
Query:       EFC37031.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.4e-11   44.4   0.7    1.4e-10   41.1   0.7    2.4  1  HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like
    1.2e-06   29.0   0.3    3.4e-06   27.5   0.3    1.7  1  HATPase_c    Histidine kinase-, DNA gyrase B-, and HSP90-like


Domain annotation for each model (and alignments):
>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.1   0.7   1.6e-14   1.4e-10       4      97 ..      98     221 ..      94     244 .. 0.69

  Alignments for each domain:
  == domain 1  score: 41.1 bits;  conditional E-value: 1.6e-14
  HATPase_c_3   4 ekAlaelvdNsldAdaenvkievnknrgktgeivieDdGkGmseeelknalrlatsskeakr.......ksts......................... 69 
                   + + el++N+ldA+a+n++i+++ ++     i i+D+G+G+ +++++   +   ++k  ++       +  +                         
   EFC37031.1  98 SDCIKELIENALDAQATNIEIQLQGKE----CIIIKDNGHGIHQDNFETLCKRYYTHKFMNHfntfndnD--Knvnnttdnlnnnesssnnhshnnne 189
                  67899********************86....8***************99887766666655534333331..02234444445555555555556666 PP

  HATPase_c_3  70 .....lGkkGiGlklAslslgkkltvitkkege 97 
                       +G kG     +++ l+k++ + tk+ +e
   EFC37031.1 190 nnnyyYGYKGEA-LNSICNLSKQVHIKTKYGDE 221
                  666666666666.55666666666666665555 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.3   3.8e-10   3.4e-06       4      65 ..      95     162 ..      92     173 .. 0.78

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 3.8e-10
                 HHHHHHHHHHHHHHHHHHSTTTEEEEEEEEEETEEEEEEEESSSSSTTHHHT........GTCS.TTCH..HC CS
   HATPase_c   4 krLrqiisnlvdNavkfatkageieveikaseddlvisveDnGiGipkedlk........klfe.kfsq..dd 65 
                 + L  +i++l++Na+++  +a++ie++++   ++ +i ++DnG Gi +++ +        + f+ +f +  d+
  EFC37031.1  95 SSLSDCIKELIENALDA--QATNIEIQLQ---GKECIIIKDNGHGIHQDNFEtlckryytHKFMnHFNTfnDN 162
                 568899**********6..89********...58999***************888866664444455556533 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1957  (0.109153); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.34s 00:00:01.11 Elapsed: 00:00:00.55
# Mc/sec: 2313.58
//
Query:       EFC37032.1  [L=607]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-10   40.1   5.0    2.1e-09   37.9   5.0    2.3  1  ING       Inhibitor of growth proteins N-terminal histone-bin
    0.00053   19.8   8.5    0.00099   19.0   8.5    1.5  1  PHD       PHD-finger
  ------ inclusion threshold ------
       0.07   13.5   0.3        1.5    9.1   0.2    2.3  2  DUF2935   Domain of unknown function (DUF2935)
       0.19   12.0   5.7        0.9    9.9   1.4    2.7  2  BLOC1_2   Biogenesis of lysosome-related organelles complex-1


Domain annotation for each model (and alignments):
>> ING  Inhibitor of growth proteins N-terminal histone-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.9   5.0   4.7e-13   2.1e-09       1     101 []     101     194 ..     101     194 .. 0.90

  Alignments for each domain:
  == domain 1  score: 37.9 bits;  conditional E-value: 4.7e-13
                 HHHHHHTSGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTS..S-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTX CS
         ING   1 yLedyldsvenLPlelqrnltelreiDakvqellkeidskiekflkngslqknekeeelsriqeelkeaqelldeKiqlaqqaldlvdkhlrrLdqdle 99 
                 yLe+++ s+e LP e+++ l  ++e+D+k+++++    + +++ +       ++  ++ + i++ ++e+++l+ eK+ ++q +l+ +  h++ L++++e
  EFC37032.1 101 YLENFVKSIEYLPTEIRKDLGTIKELDKKTSKNVTLSTELASDSS-------KSNADRSEAIRKLMDESINLSTEKVDISQRTLNKIILHMEDLEKKIE 192
                 8*****************************999887666655555.......666777889************************************99 PP

                 XX CS
         ING 100 kl 101
                 +l
  EFC37032.1 193 EL 194
                 75 PP

>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   8.5   2.2e-07   0.00099       1      51 [.     547     598 ..     547     599 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 2.2e-07
                 SBTTTTS.TTSTTSCEEEET..TTSC..EEETTTSSSTHSHHSHHSSTBSSTTTHT CS
         PHD   1 rCavCkk.ksdeeeelvqCd..gCkr..wfHqkClkppleseekpegewlCekCke 51 
                 +C  Ckk  +++++e+v Cd  +C +  w H+ Cl+p ++  + p  +++C +C++
  EFC37032.1 547 YC-YCKKtMAEDSSEMVGCDspKCPNngWIHKHCLHPGED-PDAP--QFYCLNCSK 598
                 69.9***98899********666*76559*********88.3344..6******85 PP

>> DUF2935  Domain of unknown function (DUF2935)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.2   0.00034       1.5      41      93 ..     124     180 ..     102     184 .. 0.78
   2 ?    3.1   0.0     0.026   1.2e+02      37     101 ..     178     269 ..     175     275 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00034
     DUF2935  41 keFekllaeavelseglv....rasseleeavakLneealkltreliqFkkellekv 93 
                 ke++k ++++v ls  l     + + +  ea++kL++e+++l++e ++  +++l+k+
  EFC37032.1 124 KELDKKTSKNVTLSTELAsdssKSNADRSEAIRKLMDESINLSTEKVDISQRTLNKI 180
                 44555555555555554456559999**************************99997 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.026
     DUF2935  37 kefkkeFekllaeavelseglv...........................rasseleeavakLneealkltreliqFkkellekvlscklfsi 101
                 +++  + e+l+++ +els+ +                            + +++l+ + +k n++ ++ +++l ++k+  l+   ++++  +
  EFC37032.1 178 NKIILHMEDLEKKIEELSQNIQqkpqntlkleslyipqlsednqvhyftPSDPSLQSSSSKSNKRLVQHSENLKTLKSGSLKSYPEKEMHAH 269
                 55666777788888888777766777777777777788888888888878888888888888888888888888888888888888877655 PP

>> BLOC1_2  Biogenesis of lysosome-related organelles complex-1 subunit 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.2     0.025   1.1e+02      40      89 ..      82     131 ..      67     135 .. 0.76
   2 ?    9.9   1.4    0.0002       0.9       5      62 ..     153     210 ..     149     218 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.025
     BLOC1_2  40 kdvaaslekkleklnekyeelqpylqqidqiekqvteLeeavseLDeysk 89 
                 ++++ ++ + +++ + ++  l++++++i+ + +++++   +++eLD+ ++
  EFC37032.1  82 NNSTTHAGSAIQERKDEEIYLENFVKSIEYLPTEIRKDLGTIKELDKKTS 131
                 55666677777777887888888888888888888888888888887665 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0002
     BLOC1_2   5 ekvskyleaeleatvedyklLeklNeaasekykklkdvaaslekkleklnekyeelqp 62 
                 e+++k++++ ++ ++e++++ ++  ++ + + ++l++++++l++++++  +   +l++
  EFC37032.1 153 EAIRKLMDESINLSTEKVDISQRTLNKIILHMEDLEKKIEELSQNIQQKPQNTLKLES 210
                 6789999999999999999999999999999999999999999999998887666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (607 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2817  (0.15712); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                       176  (0.0098165); expected 17.9 (0.001)
Passed Fwd filter:                        60  (0.00334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.83u 0.40s 00:00:02.23 Elapsed: 00:00:00.64
# Mc/sec: 2839.90
//
Query:       EFC37033.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-14   54.7   0.0    1.7e-14   54.3   0.0    1.2  1  Methyltransf_11  Methyltransferase domain
      3e-13   50.3   0.0    4.9e-13   49.6   0.0    1.3  1  Methyltransf_25  Methyltransferase domain
    4.1e-07   29.9   0.0    4.6e-07   29.7   0.0    1.1  1  Methyltransf_31  Methyltransferase domain
    2.2e-06   28.3   0.0    3.4e-06   27.7   0.0    1.3  1  Methyltransf_12  Methyltransferase domain
    3.8e-06   26.4   0.0    4.7e-06   26.1   0.0    1.1  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
    7.9e-05   22.6   0.0     0.0001   22.2   0.0    1.1  1  Methyltransf_23  Methyltransferase domain
    0.00053   18.7   0.0    0.00066   18.3   0.0    1.1  1  Methyltransf_29  Putative S-adenosyl-L-methionine-dependent m


Domain annotation for each model (and alignments):
>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.3   0.0   6.5e-18   1.7e-14       1      95 [.       6     105 ..       6     106 .. 0.93

  Alignments for each domain:
  == domain 1  score: 54.3 bits;  conditional E-value: 6.5e-18
                      EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-EEEETTEECCCTSS-TT-EEEEEEES-CCC-......CCHHHHHHHHHHH CS
  Methyltransf_11   1 LdvGcGtGrlaealakrg.arvvgvDlskemlklakekaseeglkvefvvadaeklpfednsfDlvvssevlhhv......edpekalkeiaRv 87 
                      L vG Gt ++  +l + g +rv+++D+s+ +++  ++k+ +++  +ef+ +da++++f++ +fD +v + +++        +  + +l+ei R+
       EFC37033.1   6 LYVGGGTSQVPFKLYEEGyKRVTTIDYSEGAMESMRRKNTNPD--LEFLTMDAKHTNFPSWYFDYIVDKACFESEfcadwtHGAKTYLDEINRI 97 
                      679************9999**********************99..99***********************988877777778999********* PP

                      EEEEEEEE CS
  Methyltransf_11  88 LkpgGllv 95 
                      LkpgG+ +
       EFC37033.1  98 LKPGGMYM 105
                      *****976 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.6   0.0   1.9e-16   4.9e-13       3      97 .]       7     102 ..       6     102 .. 0.88

  Alignments for each domain:
  == domain 1  score: 49.6 bits;  conditional E-value: 1.9e-16
                      EET-TTSHHHHHHHCTSTSSEEEEEESSHHHHHHHHHHHHHTTTTEEEEESBCCGBSSSTTTEEEEEEESTGG....GSSHHHHHHHHHHHHHH CS
  Methyltransf_25   3 dlGcGtGrltlalakrlgkakvtgvDiseemleaareraeeeglnvefvqgdaedlpfedgsfDlvvssgalh....hlsdedlekalkeiarv 92 
                       +G Gt ++ ++l ++ g ++vt +D+se+++e +r+++   ++++ef+++da++ +f++  fD++v   +++      + + ++++l+ei r+
       EFC37033.1   7 YVGGGTSQVPFKLYEE-GYKRVTTIDYSEGAMESMRRKN--TNPDLEFLTMDAKHTNFPSWYFDYIVDKACFEsefcADWTHGAKTYLDEINRI 97 
                      69**************.69********************..679***********************9766773332334566799******** PP

                      EEEEE CS
  Methyltransf_25  93 LkpgG 97 
                      LkpgG
       EFC37033.1  98 LKPGG 102
                      ****9 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.0   1.8e-10   4.6e-07      10     112 ..       8     109 ..       2     153 .. 0.79

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 1.8e-10
  Methyltransf_31  10 lGCGtGeltfelaeelgpkaevvGiDiseeaielArenaqklgldnveFeqgdieeleklledekfDlilsnevl.....naladpdkile.ei 97 
                      +G Gt++  f+l+ee +  ++v+ iD+se a e++r +  + +   +eF   d+ + +  +    fD+i++++ +     ++ ++ +k++  ei
       EFC37033.1   8 VGGGTSQVPFKLYEEGY--KRVTTIDYSEGAMESMRRK--NTNP-DLEFLTMDAKHTN--FPSWYFDYIVDKACFesefcADWTHGAKTYLdEI 94 
                      899**********7654..68***************95..3344.4778888888866..55566*******77777777999998887655** PP

  Methyltransf_31  98 ervlkpggilliedp 112
                       r lkpgg +++ ++
       EFC37033.1  95 NRILKPGGMYMMISH 109
                      ********9999876 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.0   1.3e-09   3.4e-06       2      98 ..       7     103 ..       6     104 .. 0.81

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 1.3e-09
  Methyltransf_12   2 eiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvelealdlldldggssfDlvvasnvlhhl......kdirevldni 89 
                       +G+Gt+++ + l e+   +++t +D+s+ a+    ++ + + ++ +  ++ ++++  +     +fD++v   +++           + +ld+i
       EFC37033.1   7 YVGGGTSQVPFKLYEE-GYKRVTTIDYSEGAM-ESMRRKNTNPDLEFLTMDAKHTNFPS----WYFDYIVDKACFESEfcadwtHGAKTYLDEI 94 
                      59**************.999************.66666677777777888888777554....4******6666665555666688999***** PP

  Methyltransf_12  90 rklLkpgGr 98 
                       + LkpgG+
       EFC37033.1  95 NRILKPGGM 103
                      ********7 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   0.0   1.8e-09   4.7e-06      50     191 ..       4     152 ..       1     159 [. 0.76

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 1.8e-09
                      EEEEES-TT-HHHHHHHHHHHHHHEEEEEES-HHHHHHHHHHHHHHTSSTEEEEE--TTT-TTS-T-EEEEE..EES-GGG-S-....HHHHHH CS
  Ubie_methyltran  50 kvlDvagGtgDlafklsdsvgekgkvvvlDinenmLkvgekklkeegkinieflqanaeeLpfeddsfDvvt..vsfGlrnvtD....klkaLk 137
                      + l v gGt+ + fkl ++  +  +v+ +D++e  ++  ++k    +  ++efl+ +a++ +f    fD++     f     +D     ++ L 
       EFC37033.1   4 HTLYVGGGTSQVPFKLYEEGYK--RVTTIDYSEGAMESMRRKN---TNPDLEFLTMDAKHTNFPSWYFDYIVdkACFESEFCADwthgAKTYLD 92 
                      568899**********987655..6899*****9988877664...45699******************9853344554444441111678899 PP

                      HHHHHEEEEEEEEEEE.E-.---SHHHHHHHHHHHH.H....HHHHHHHHHS-HHHHHHH CS
  Ubie_methyltran 138 eayrvlkpGGrlvvle.fs.kvelpllsqayelyskev....lPvlGkllakdldsyryL 191
                      e+ r+lkpGG  +++  fs    lpll++ y +++  v     P +  +  ++ ds+ yL
       EFC37033.1  93 EINRILKPGGMYMMIShFSpDKRLPLLEVDYLQWTVLVerqnKPNFSTIPNDENDSFYYL 152
                      **********998886256235689*********98663333588888888888888887 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.0     4e-08    0.0001      30     144 ..       9     137 ..       4     143 .. 0.75

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 4e-08
  Methyltransf_23  30 GcGtGillevlrengf.svtgvDlspeaveiaekakkaqkdqfdeqeaae...pqgkfdlIvlrevlehvp..dpp....ellrqiatllkpgG 113
                      G Gt  +   l e+g+  vt +D s+ a e  + + ++++  f  ++a+    p+ +fd+Iv   ++e+    d++     +l+ i+++lkpgG
       EFC37033.1   9 GGGTSQVPFKLYEEGYkRVTTIDYSEGAMESMRRKNTNPDLEFLTMDAKHtnfPSWYFDYIVDKACFESEFcaDWThgakTYLDEINRILKPGG 102
                      666665555677889979********999999966666666665555544333888************9655699988889***********96 PP

  Methyltransf_23 114 .ylllse..plaslk.edrllldwlylvpagrhis 144
                       y+++s   p+++l+  + ++l+w+ lv++  + +
       EFC37033.1 103 mYMMISHfsPDKRLPlLEVDYLQWTVLVERQNKPN 137
                      26777774455555557888999999998865555 PP

>> Methyltransf_29  Putative S-adenosyl-L-methionine-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   2.6e-07   0.00066     170     219 ..      54     108 ..      50     125 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 2.6e-07
  Methyltransf_29 170 lgtkrlpyPsrsfdlihCsrC.....ridwteedgilllevdRvlRpgGyfvlsa 219
                      + +k+  +Ps  fd i    C       dwt+   ++l e++R+l+pgG +++ +
       EFC37033.1  54 MDAKHTNFPSWYFDYIVDKACfesefCADWTHGAKTYLDEINRILKPGGMYMMIS 108
                      5678889*******997666633332589********************988654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       463  (0.0258241); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.33u 0.21s 00:00:00.54 Elapsed: 00:00:00.36
# Mc/sec: 1353.32
//
Query:       EFC37034.1  [L=847]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (847 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       961  (0.0536003); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.26s 00:00:00.91 Elapsed: 00:00:00.43
# Mc/sec: 5924.57
//
Query:       EFC37035.1  [L=415]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      9e-08   32.1   0.0    1.5e-07   31.4   0.0    1.3  1  Abhydrolase_1  alpha/beta hydrolase fold
    1.1e-06   28.1   0.0    1.8e-06   27.4   0.0    1.3  1  Hydrolase_4    Serine aminopeptidase, S33
    0.00058   20.5   0.0    0.00074   20.2   0.0    1.2  1  Abhydrolase_6  Alpha/beta hydrolase family


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   0.0   2.4e-11   1.5e-07       2     111 ..     134     254 ..     133     279 .. 0.82

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 2.4e-11
                    EEEEE-STTT..CGGG...GTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB.......CHHSHHHHHHHHHHH..HHHCTTSSEEEEEETHHH CS
  Abhydrolase_1   2 vlvilhGlpg..ssdv...waerglapaLakdgfdvillDlrGvgySspapacin......ddygtasvaddldri..ldalgddkltlvGhSmGG 84 
                    +++++hG+ +  +++    +++  l +a+++ ++d+ ++  r++g+S++   ++       ++yg + +ad+l +i     lg +++ l G SmGG
     EFC37035.1 134 LILLVHGFRMrqNHYTiiiPIQ-MLLKAFPDGEYDFMTMEYRNHGFSQKEYPSNLlpdksySTYGSIEYADVLGAItyARNLGYEEIGLYGPSMGG 228
                    6888899888775544332333.455555555*****************9998779******************99999***************** PP

                    HHHHHHHHHH..GGGEEEEEEESECSSCC CS
  Abhydrolase_1  85 mialayaaey..perVkalvllgaidpaa 111
                    ++ ++++++   +++++al l+++   a 
     EFC37035.1 229 ATIMNAYLRSnsQDNIRALFLDSP---AC 254
                    *9999999999************9...33 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.4   0.0   3.1e-10   1.8e-06       2     132 ..     130     274 ..     129     289 .. 0.82

  Alignments for each domain:
  == domain 1  score: 27.4 bits;  conditional E-value: 3.1e-10
  Hydrolase_4   2 epkavvvlvHGlaehsgry......aelaeaLaaqGfavyalDhrGhGrse........gkrghvpsfddyvdDlaafvekvkeehpelplfllGhSm 85 
                  + k++++lvHG+    + y      + l +a+ + +++++++ +r hG s+        + + + +  +  ++D+  +++ ++ + + +++ l+G Sm
   EFC37035.1 130 KSKKLILLVHGFRMRQNHYtiiipiQMLLKAFPDGEYDFMTMEYRNHGFSQkeypsnllPDKSYSTYGSIEYADVLGAITYAR-NLGYEEIGLYGPSM 226
                  67999******988777774445557899**************************999999999999999999**99999998.455567******** PP

  Hydrolase_4  86 GGliallyl..lrypdkvaglilsaPalkikaklkappllklllkllgk 132
                  GG++ +++    + +d++++l l +Pa++i+  l  + l+++l   lg+
   EFC37035.1 227 GGATIMNAYlrSNSQDNIRALFLDSPACDIEFTL-QSNLYRVLGYALGH 274
                  *****999955555569*************9665.66777776666655 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.2e-07   0.00074       1     105 [.     135     261 ..     135     351 .. 0.64

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.2e-07
                    EEEE--GC.....G...C.HHHHHHHHCCT...CEEEEE--TTST.......S-GGCS--HHHC..HHHHHHHCCTT......TTSEEEEEETCHH CS
  Abhydrolase_6   1 vlllHGagssassW...l.vapLaallaag...vhvlapDlpGhG.......rsdpppldledl..adlaalldelaa....gggpvvlvGHSlGG 76 
                    +ll+HG+ + + ++        L++++++g   +   ++ +++hG       ++  p+ +++ +   ++a++l ++      g+ ++ l G S+GG
     EFC37035.1 135 ILLVHGFRMRQNHYtiiIpIQMLLKAFPDGeydF--MTMEYRNHGfsqkeypSNLLPDKSYSTYgsIEYADVLGAITYarnlGYEEIGLYGPSMGG 228
                    89****9988777854313345588888889555..9********66666653355555555532266677666665566689************9 PP

                    HHHHHHHHCC........EE.EEES-..----TTT..S CS
  Abhydrolase_6  77 alalaaapla......lvvg.vlldppptalpagl..l 105
                    a  +    +       ++++ ++ld+  +a+++ +  +
     EFC37035.1 229 ATIMN---AYlrsnsqDNIRaLFLDS--PACDIEFtlQ 261
                    97777...333446884445599999..3444433322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (415 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       674  (0.0375927); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.55
# Mc/sec: 2282.02
//
Query:       EFC37036.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.043   13.7   0.2       0.11   12.5   0.2    1.7  1  F-box          F-box domain
        0.3   11.4  10.1          2    8.8   0.5    3.3  3  Borrelia_orfD  Borrelia orf-D family


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.2   1.2e-05      0.11      17      47 ..      22      52 ..       9      53 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.2e-05
                TS-HHHHHHHCTT-HHHHHHHTTHHHHHHHH CS
       F-box 17 rLplsdllalrrVSkgwrilidsdrlwcksi 47
                + +l+++ +l++++++++ +i +++  ++++
  EFC37036.1 22 HDDLKSVMNLASTCTTLYAAITECSERLWIY 52
                447888*****************99999985 PP

>> Borrelia_orfD  Borrelia orf-D family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.2    0.0034        31      38      66 ..     111     140 ..      71     165 .. 0.68
   2 ?    8.8   0.5   0.00023         2      44      81 ..     176     213 ..     170     226 .. 0.87
   3 ?    2.7   0.8     0.017   1.6e+02      48      88 ..     258     296 ..     216     305 .. 0.72

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0034
  Borrelia_orfD  38 vkskvik.yynddkfPvfeyfdlvtldeeg 66 
                     k +++k yy++ +f +++yf     +++ 
     EFC37036.1 111 RKHQILKgYYEERDFAKYKYFSNLNIKDDY 140
                    45666665999**********988888875 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00023
  Borrelia_orfD  44 kyynddkfPvfeyfdlvtldeegskeanilknritiyl 81 
                     y+n   + v e+ d ++ +e+   e ni  + i+ yl
     EFC37036.1 176 LYFNGSMYTVKEFIDAIFRKENAHLELNIHNRTISSYL 213
                    49999*****************************9986 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.017
  Borrelia_orfD  48 ddkfPvfeyfdlvtldeegskeanilknritiylryikktk 88 
                     ++  +  + + ++ +e+++k +   kn + ++++y+   +
     EFC37036.1 258 FPNVMNGSNQETAYEQEKHTKGS--FKNTLLYFKNYLANVQ 296
                    44444556777888999999999..***********97665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       857  (0.0477997); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2061.42
//
Query:       EFC37037.1  [L=361]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0057   16.5   0.1      0.016   15.1   0.1    1.7  1  F-box     F-box domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.1   8.9e-07     0.016       4      43 ..      11      50 ..      10      54 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 8.9e-07
                HHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHH CS
       F-box  4 srLPsevlrhILerLplsdllalrrVSkgwrilidsdrlw 43
                s+L+ + +++IL++L+ + ++ + +  ++w+i+  s  +w
  EFC37037.1 11 SQLCHDEILNILQFLNVKQIVKCLLINTNWNIIGSSNIIW 50
                6799999************************997666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (361 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1134  (0.0632495); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.24s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2389.38
//
Query:       EFC37038.1  [L=2445]
Description: hypothetical protein NAEGRDRAFT_82025 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      7e-15   55.1   3.3      7e-15   55.1   3.3    3.4  3  Vps8           Golgi CORVET complex core vacuolar protein 8
  ------ inclusion threshold ------
        6.2    6.8  11.2         24    4.9   8.2    3.3  2  Cnd1           non-SMC mitotic condensation complex subunit 1


Domain annotation for each model (and alignments):
>> Vps8  Golgi CORVET complex core vacuolar protein 8
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.1   3.3   7.8e-19     7e-15      31     198 .]    1229    1394 ..    1222    1394 .. 0.85
   2 !    5.7   4.6    0.0011       9.6      58     195 ..    1623    1808 ..    1618    1810 .. 0.78
   3 ?   -3.2   0.0      0.56     5e+03       8      46 ..    2169    2207 ..    2166    2216 .. 0.75

  Alignments for each domain:
  == domain 1  score: 55.1 bits;  conditional E-value: 7.8e-19
        Vps8   31 sskgelerleelilhldpksLDldqvlkl.....ckehrLydaliYvwnkaldDYvtPlvellklirsaeeeeeekeeeeeeeeeaykvfeYlsyiL 122 
                  s k ++erle++il+ld+++L +++ + l     ck+++Ly++ iY    + +D++tP+ + l+ i+       ++ ++ e++e+a  ++eY ++i 
  EFC37038.1 1229 SPKVRFERLESIILNLDISKLQIEYEIFLelnekCKRYNLYRMHIYSNCVLNSDFITPVRDYLEDITI------SDLSTVETKEKADAILEYFKNIV 1319
                  5677899****************98764444555*************999999**************9......5677888999999******9998 PP

        Vps8  123 t.GraYPsgee.leeeeaskakseiyslLfsgksiewpkgsgklltkeeseeepafPylrlLLkfdaeeflsvLneaF 198 
                  t G  +  + +  + e  +k+k+ i+++Lf+++ +   ++   +++++++++  a  +l+ L+k++ +e+++vL++ F
  EFC37038.1 1320 TkGTIFTDAYHiTDVEVLKKVKRLIVDFLFEQTRVVRMSS---NSQEKHKNNGIAMLNLEKLIKYNPKETFDVLKLYF 1394
                  6699***999956666699***********7765554433...3467788888999*******************988 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0011
        Vps8   58 klckehrLydaliYvwnkaldDYvtPlvellklirsa................................e........................... 95  
                     +e++ y+a +Y+ n+  +DY++ + + ++ ++                                  +                           
  EFC37038.1 1623 DYAQENNCYQAAVYL-NRKKKDYKAVIKNYIDDLKLKkaighsqldtpvfsyiselandsevitisihdAildhfldlmkadseemtllivkyfptl 1718
                  567899999999999.999999999999999888877667777777777766666666665555555550555555566666667777777788888 PP

        Vps8   96 ...eeeeekeeeeeeeeeaykvfeYlsyiLtGraYPsgeeleeeeaskakseiyslLfsgksiewpkgsgklltkeeseeepafPylrlLLkfdaee 189 
                       ++  +++ ++ e++  +f+Yls i+  + Y  +++l + +a++  s++ ++++s +           +tk + + e ++ y+rlL kf+  +
  EFC37038.1 1719 hpqVLNTLITSSIKHIEDERLLFNYLSKII--NIYEGNNDLIDVKANTSSSTMSQFFTSMT-----------RTKIDVDMELQYQYIRLLCKFEPHK 1802
                  87655666677888999999*********9..6999888899999***********99887...........4668999***************999 PP

        Vps8  190 flsvLn 195 
                  + + L+
  EFC37038.1 1803 VCDWLQ 1808
                  988876 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 0.56
        Vps8    8 pyilsgklkslp.pevvkalvehysskgelerleelilhl 46  
                   +++ + + slp pe++k+l +    k +++ + +++lhl
  EFC37038.1 2169 RVVVLSAIGSLPiPEILKKLTKEN-AKSDFSMYRQILLHL 2207
                  567777888888789999988776.556799999999986 PP

>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   8.2    0.0027        24      53     150 ..    1509    1630 ..    1499    1648 .. 0.82
   2 ?    0.2   0.0     0.074   6.6e+02      99     146 ..    1672    1719 ..    1646    1734 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0027
        Cnd1   53 mvkekgflselaklleDenprVvanalaalteiseksenaiynllpdiisklsdalne........................csewgqitilefLls 125 
                  + ++kg+++++++ l+ +n   ++ ++ +l++ +e ++  + + + ++++   +a +e                        +++  q+  +++L +
  EFC37038.1 1509 LAEDKGQIKRIYTHLCHDNVFTSDETKELLKQFKEHEKASTETKKGKSLHLTEQARQEsverimkqtsylnerkeylikeydFKRHRQNILMKILEK 1605
                  678999******************************9866666666666666664444555555556666667778888888*************** PP

        Cnd1  126 yipkdkqeaeslveklcprlqhans 150 
                    ++++q++ +++ +l++  q +n+
  EFC37038.1 1606 LESSNEQTISTILVRLIDYAQENNC 1630
                  *********************9997 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.074
        Cnd1   99 diisklsdalnecsewgqitilefLlsyipkdkqeaeslveklcprlq 146 
                  ++is l ++ + ++      il+  l+ ++ d++e+  l+ k  p l 
  EFC37038.1 1672 SYISELANDSEVITISIHDAILDHFLDLMKADSEEMTLLIVKYFPTLH 1719
                  456666667677888888999****************99999888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2660  (0.148363); expected 358.6 (0.02)
Passed bias filter:                      458  (0.0255452); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.53u 0.34s 00:00:01.87 Elapsed: 00:00:00.57
# Mc/sec: 12920.44
//
Query:       EFC37039.1  [L=767]
Description: hypothetical protein NAEGRDRAFT_82029 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00078   20.1   7.9         14    6.4   0.0    6.3  6  YbjQ_1          Putative heavy-metal-binding
  ------ inclusion threshold ------
      0.049   13.8  10.1        5.7    7.1   0.1    4.8  5  SAM_KSR1        SAM like domain present in kinase suppressor 
      0.061   13.8   0.2        1.9    9.1   0.0    2.9  2  HPPK            7,8-dihydro-6-hydroxymethylpterin-pyrophospho
      0.063   12.4  10.4       0.24   10.5  10.5    2.0  1  APG17           Autophagy protein Apg17
        1.3    9.5  13.0        4.2    7.8   0.0    4.8  4  DUF4600         Domain of unknown function (DUF4600)
        1.4    9.4  13.1       0.16   12.4   4.3    2.7  3  Fez1            Fez1
        2.1    8.7   6.9         28    5.2   0.1    4.6  4  HHH_8           Helix-hairpin-helix domain
        4.4    6.1   9.5        2.8    6.8   6.3    2.2  2  DUF726          Protein of unknown function (DUF726)
        4.6    7.5   7.1         58    4.0   0.1    3.9  4  B-block_TFIIIC  B-block binding subunit of TFIIIC


Domain annotation for each model (and alignments):
>> YbjQ_1  Putative heavy-metal-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0         5   9.9e+03      34      52 ..     187     205 ..     175     216 .. 0.75
   2 ?    2.7   0.0     0.095   1.9e+02      32      52 ..     278     298 ..     271     311 .. 0.81
   3 ?    5.0   0.1     0.018        36      30      56 ..     359     385 ..     344     412 .. 0.82
   4 !    6.4   0.0     0.007        14      25      57 ..     437     469 ..     415     486 .. 0.81
   5 ?    1.2   0.0      0.29   5.8e+02      28      59 ..     523     554 ..     511     559 .. 0.83
   6 ?    2.5   0.0      0.11   2.3e+02      25      59 ..     603     637 ..     587     648 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 5
      YbjQ_1  34 dilaglrslvGGelkayee 52 
                  ++ gl+ ++GG++k +++
  EFC37039.1 187 MVIGGLNAVTGGKSKLLNK 205
                 5677889999999887665 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.095
      YbjQ_1  32 lkdilaglrslvGGelkayee 52 
                 +++i+++l++l+GG++ka+++
  EFC37039.1 278 GQEITSSLNNLTGGKIKALNK 298
                 67899***********99876 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.018
      YbjQ_1  30 nvlkdilaglrslvGGelkayeeelee 56 
                   +kdil+++++++GG++k++++ ++ 
  EFC37039.1 359 GKTKDILSSVNEVTGGKSKKLNKIINA 385
                 5689****************9998875 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.007
      YbjQ_1  25 tvrsrnvlkdilaglrslvGGelkayeeeleea 57 
                    s   +kd+l++++ + GG++k++++++++ 
  EFC37039.1 437 LDNSLGKGKDFLQQVNAINGGKSKTLNKLIQKL 469
                 55666779*******************999875 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.29
      YbjQ_1  28 srnvlkdilaglrslvGGelkayeeeleeare 59 
                 ++   +d++++l++++ G++k++ +++e+ ++
  EFC37039.1 523 AMANAEDFVSQLNTFTNGRSKTLVSLVEKLKK 554
                 5566789****************999998875 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.11
      YbjQ_1  25 tvrsrnvlkdilaglrslvGGelkayeeeleeare 59 
                 +  + + +++i+++l+++  G+ k++ ++l++ r+
  EFC37039.1 603 VAGAFSKGENIVSELNEISNGKNKNLAKLLQSLRK 637
                 333445567788889****************9997 PP

>> SAM_KSR1  SAM like domain present in kinase suppressor RAS 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.59   1.2e+03      74     113 ..     308     347 ..     292     353 .. 0.84
   2 ?    2.7   0.2     0.064   1.3e+02      51     112 ..     365     429 ..     325     437 .. 0.76
   3 ?    5.7   0.1    0.0076        15      61     114 ..     460     514 ..     444     528 .. 0.79
   4 ?    7.1   0.1    0.0029       5.7      60     112 ..     542     595 ..     527     610 .. 0.81
   5 ?    0.2   0.2      0.39   7.8e+02      69     114 ..     635     680 ..     607     687 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.59
    SAM_KSR1  74 rvvglsqetleailnkklsleelLkmseeelkqllsevqa 113
                 ++ g+ + +l+++ + + sl++l + ++ ++k+ll++ + 
  EFC37039.1 308 KIAGIGSGALNGLGKGLDSLKNLKNFKNIDMKKLLTSENI 347
                 678999999999999999****************988665 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.064
    SAM_KSR1  51 ksklaerer..anelqky.pelkqWLrvvglsqetleailnkklsleelLkmseeelkqllsevq 112
                  s+++e +   +++l+k  + l +  ++v + +++++ i + k s+ +l + +++++k+l+++ +
  EFC37039.1 365 LSSVNEVTGgkSKKLNKIiNALDKTQNIVSVGSNAVDRIKGIKNSIADLKNFQSSKIKDLFTNEG 429
                 45555544333778887779999999********************************9998754 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0076
    SAM_KSR1  61 nelqky.pelkqWLrvvglsqetleailnkklsleelLkmseeelkqllsevqae 114
                 + l+k  ++l++  + v + +++++  ++ k+s+e+l +m++ +lk+ll+  +++
  EFC37039.1 460 KTLNKLiQKLEKGQQAVAIGSTAAKRYEGIKSSIEKLSNMKSGDLKNLLNFENVQ 514
                 4454444678888889*********************************975554 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0029
    SAM_KSR1  60 anelqky.pelkqWLrvvglsqetleailnkklsleelLkmseeelkqllsevq 112
                 ++ l +  ++lk+  +v  + +++l++  + k sle+l ++++e+++++l + +
  EFC37039.1 542 SKTLVSLvEKLKKGQKVTSVTSKILDGAKGIKGSLEQLKNLKKEDMQKVLDAEH 595
                 455555558999999**********************************98744 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.39
    SAM_KSR1  69 lkqWLrvvglsqetleailnkklsleelLkmseeelkqllsevqae 114
                 l++   + +  ++ + +  + k s+ee+ k++ ++l+++l++ + +
  EFC37039.1 635 LRKGQMIANTASSGVGTYKSAKNSIEEMKKLKGKNLEEILKSDELN 680
                 4444445555666666777889999999999999999999986555 PP

>> HPPK  7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.0   0.00094       1.9       2      68 ..     393     471 ..     392     476 .. 0.78
   2 ?    1.5   0.1      0.21   4.3e+02       2      25 ..     476     506 ..     475     567 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00094
                 EEEEE-SSSHHHHHHHHHHHHHH.EEEEE---EEE--S............SS-GEEEEEEEEEESS-HHHHHHHHHHHHH CS
        HPPK   2 lalGsNlgdreanleealealee.kvvkvSslyetepv............dqpdFlNavvevetelspeellealkeiEk 68 
                 +++GsN  dr + +++ ++ l++ +  k+ +l++ e +            + +dFl +v +++   + ++l + ++++Ek
  EFC37039.1 393 VSVGSNAVDRIKGIKNSIADLKNfQSSKIKDLFTNEGIqkalgkldnslgKGKDFLQQVNAINGG-KSKTLNKLIQKLEK 471
                 89*******************88766788888888877766676655443357899999999875.66888888888887 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.21
                 EEEEE-SSSHHHHHHHHHHHHHH.......E CS
        HPPK   2 lalGsNlgdreanleealealee.......k 25 
                 +a+Gs   +r++ +++ +e+l++       +
  EFC37039.1 476 VAIGSTAAKRYEGIKSSIEKLSNmksgdlkN 506
                 899******************7654444431 PP

>> APG17  Autophagy protein Apg17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5  10.5   0.00012      0.24      14     328 ..     362     684 ..     340     712 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00012
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHIIIIIIIIIIIIIIIIIHHHHH..HHHHHHHHHHHHHHHHTSS-TTS.......S CS
       APG17  14 qtlcqrAnelltsarqeleeavkllakteflrdglkqQlkllekirkslerklekgkeefkdlike..ldaanerLektlekLrktkvepsfrpegeek 110
                 + + ++ ne++   +++l+++ + l+kt+ +++  ++ ++ ++ i++s+ + ++  ++++kdl ++  +++a ++L++ l k ++   + +  + g++k
  EFC37039.1 362 KDILSSVNEVTGGKSKKLNKIINALDKTQNIVSVGSNAVDRIKGIKNSIADLKNFQSSKIKDLFTNegIQKALGKLDNSLGKGKDFLQQVNAINGGKSK 460
                 444455555555555555555555566666666666666666666666666665555555555544456666666666666655555555555555445 PP

                 TGGGCS-.....-TTT...THHHHHHHHH.......HHHHHHHHHHHHTTHH..HHHHHHHHHHH.-------STCCHHHHHHHHHHHHHHHHHHHHHH CS
       APG17 111 tLlDFvd.....edsv...eelkealkes.......idelqaaqkkldssllefdtdlrelkkel.sksksksessslipellkelesleeemAslLes 193
                 tL   +      +++v   +                ++ ++++ +  +++l+++  +++++++ l ++++  +++++++++l +  + +++ ++sl e 
  EFC37039.1 461 TLNKLIQklekgQQAVaigS---T----AakryegiKSSIEKLSNMKSGDLKNLL-NFENVQTGLgKAKNAMANAEDFVSQLNTFTNGRSKTLVSLVEK 551
                 55555552222112222221...1....011123333333333333333333333.3445555553222222355555555555555555555555555 PP

                 HHHHHHHHHHH.......................................S-CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       APG17 194 LtnHfDqcvkAvkltegggalrraaae.......................lseeereelleVlekDaaeledVvkelqerleemekakkllsekkeeie 269
                 L +                                               l++  +e++ +Vl  Da++l+ V++ +   +++ e++ ++l+e  + ++
  EFC37039.1 552 LKK-----------------------GqkvtsvtskildgakgikgsleqLKNLKKEDMQKVL--DAEHLQGVLNRVAGAFSKGENIVSELNEISNGKN 625
                 544.......................03333333334444444456666789999999****9..9********************************* PP

                 HHHHHHHHHHHHHH....HHHHHHHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHH CS
       APG17 270 kllsalkkaleeleevgkklpeylaifkaeeeflerweeekekieekleeleeLrefYe 328
                 k l++l + l++ + + ++ ++ + + k++++ +e+ ++ k k  e++ + +eL e  +
  EFC37039.1 626 KNLAKLLQSLRKGQMIANTASSGVGTYKSAKNSIEEMKKLKGKNLEEILKSDELNEVID 684
                 **************99********************99999999999988888887765 PP

>> DUF4600  Domain of unknown function (DUF4600)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.2    0.0091        18      29      69 ..     353     393 ..     334     397 .. 0.86
   2 ?    7.8   0.0    0.0021       4.2      21      69 ..     432     476 ..     424     479 .. 0.78
   3 ?    1.3   0.1      0.22   4.3e+02      29      67 ..     519     557 ..     482     567 .. 0.79
   4 ?   -1.2   0.6       1.3   2.5e+03      35      60 ..     650     675 ..     611     718 .. 0.60

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0091
     DUF4600  29 klekirgnpsdrlasirvleklteeelnqllkqLekekksl 69 
                 kl+++ g+ +d+l+s++ +    +++ln++++ L+k ++++
  EFC37039.1 353 KLDSTIGKTKDILSSVNEVTGGKSKKLNKIINALDKTQNIV 393
                 6677779999**************************99876 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0021
     DUF4600  21 kqiailkeklekirgnpsdrlasirvleklteeelnqllkqLekekksl 69 
                 k +  l+++l    g+ +d l+ +++++   +++ln+l+++Lek ++++
  EFC37039.1 432 KALGKLDNSL----GKGKDFLQQVNAINGGKSKTLNKLIQKLEKGQQAV 476
                 4444444444....55569*************************99876 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.22
     DUF4600  29 klekirgnpsdrlasirvleklteeelnqllkqLekekk 67 
                 k++++  n +d  + ++++ +  +++l +l+++L+k +k
  EFC37039.1 519 KAKNAMANAEDFVSQLNTFTNGRSKTLVSLVEKLKKGQK 557
                 444455677788888888888888999999999998876 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 1.3
     DUF4600  35 gnpsdrlasirvleklteeelnqllk 60 
                 g  +   +si+ ++kl  ++l+++lk
  EFC37039.1 650 GTYKSAKNSIEEMKKLKGKNLEEILK 675
                 44444555555566666666655554 PP

>> Fez1  Fez1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.2      0.17   3.5e+02      38     115 ..     349     439 ..     326     478 .. 0.49
   2 ?   -1.3   0.2       1.2   2.5e+03      45     107 ..     487     549 ..     468     565 .. 0.64
   3 ?   12.4   4.3   7.9e-05      0.16      17     149 ..     577     712 ..     574     721 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.17
        Fez1  38 aqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvek...leeelkelreelselsleeeeaa.................l 115
                   l  l +++ ++ + +++++e +  k+++l+++ n l+++++ +++ ++ v++   +++ +++l++  s+       ++                 +
  EFC37039.1 349 KGLGKLDSTIGKTKDILSSVNEVTGGKSKKLNKIINALDKTQNIVSVGSNAVDRikgIKNSIADLKNFQSS-------KIkdlftnegiqkalgkldN 439
                 44445555555666666677777777888888888888888777766655443300034444444442222.......21222223344444444331 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.2
        Fez1  45 akleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelsels 107
                 + ++++ e+++++++   +  l+ e+++  l ++k+   + ++ v++l++ +++  ++l +l 
  EFC37039.1 487 EGIKSSIEKLSNMKSGDLKNLLNFENVQTGLGKAKNAMANAEDFVSQLNTFTNGRSKTLVSLV 549
                 555555566666666666677778888888888888888888888888776666555555543 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 7.9e-05
        Fez1  17 qQLkdsqaevtqklseivalkaqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelselsleeeeaal 115
                 +QLk+ ++e  qk+ +  +l++ l  +  + ++ e+ ++el+e ++ k+++l ++ + l++ +  a++ +  v+++++  +++ e +++l+ ++ e++l
  EFC37039.1 577 EQLKNLKKEDMQKVLDAEHLQGVLNRVAGAFSKGENIVSELNEISNGKNKNLAKLLQSLRKGQMIANTASSGVGTYKSAKNSIEE-MKKLKGKNLEEIL 674
                 6************************************************************987777777777666655444443.5555556666677 PP

        Fez1 116 esdeakaqrqe....aeeleelkreverlraeLkeerq 149
                 +sde ++  ++     ++ +e +++ ++l++eLk+++ 
  EFC37039.1 675 KSDELNEVIDSwrgtIKQGKEFTSQFKELKNELKKKET 712
                 77776665554333356666677777777777776554 PP

>> HHH_8  Helix-hairpin-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.2       1.3   2.6e+03      26      37 ..     113     124 ..      91     141 .. 0.53
   2 ?    2.2   0.1      0.12   2.3e+02      41      58 ..     298     315 ..     291     336 .. 0.81
   3 ?    1.1   0.0      0.26   5.1e+02      44      61 ..     394     412 ..     377     424 .. 0.71
   4 ?    5.2   0.1     0.014        28       1      41 [.     625     666 ..     625     682 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.3
                 HHHHHHHCCCCC CS
       HHH_8  26 raYrrAaraiea 37 
                 ra+rr+ ra ++
  EFC37039.1 113 RAFRRVGRAFRK 124
                 344444333333 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.12
                 -HHHH.TTHCTTSTT--HH CS
       HHH_8  41 eitsl.eeeltklpgiGkk 58 
                 +i s+ ++ ++k+ giG +
  EFC37039.1 298 KISSGlDK-AQKIAGIGSG 315
                 57777455.9*******86 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.26
                 HH.TTHCTTSTT--HHHHH CS
       HHH_8  44 sl.eeeltklpgiGkkiaa 61 
                 s+   ++ +++gi ++ia+
  EFC37039.1 394 SVgSNAVDRIKGIKNSIAD 412
                 3333358889999999986 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.014
                 HHHHHHHHHHHHHHHHHCT--CCCHHHHHHHHCCCCC-SS.- CS
       HHH_8   1 NkeiadaLeeladllelkgedpfrvraYrrAaraiealpe.e 41 
                 Nk++a++L+ l +   ++++ +  v  Y+ A ++ie++++ +
  EFC37039.1 625 NKNLAKLLQSLRKGQMIANTASSGVGTYKSAKNSIEEMKKlK 666
                 999**********************************98755 PP

>> DUF726  Protein of unknown function (DUF726)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   6.3    0.0014       2.8      12      70 ..     138     199 ..     129     216 .. 0.68
   2 ?   -1.5   0.1      0.45   9.1e+02      73     125 ..     652     705 ..     627     710 .. 0.63

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0014
      DUF726  12 AglaGgaligltggLaaPlvaagigallaglGltgsaa.fLasvggsa..vitallgaagAk 70 
                 A +a +al   tggL aP +a+++g++ +++  ++++   ++s++  a  vi+ l +++g k
  EFC37039.1 138 AIIAPIALTIATGGLGAPSLAGSLGSIGSTVAKGAAMLaKVSSIASKAnmVIGGLNAVTGGK 199
                 556667777789***************99998866665445555555544444444444433 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.45
      DUF726  73 vkkmkkrvkeikdFefiplseqirlksltvtvsis.lelsdeddvtapwralak 125
                  k  k+ ++e+k+ + + l+e  ++ +l  ++  + +++++ +++t ++++l++
  EFC37039.1 652 YKSAKNSIEEMKKLKGKNLEEILKSDELNEVIDSWrGTIKQGKEFTSQFKELKN 705
                 233444556666666677777777777766665552457888889999988876 PP

>> B-block_TFIIIC  B-block binding subunit of TFIIIC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.2     0.043        85      24      72 ..     368     416 ..     363     419 .. 0.86
   2 ?    1.4   0.0      0.19   3.7e+02      12      40 ..     482     509 ..     479     510 .. 0.85
   3 ?   -3.4   0.0       5.6   1.1e+04      25      49 ..     535     559 ..     531     574 .. 0.67
   4 ?    4.0   0.1     0.029        58       8      60 ..     600     653 ..     598     664 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.043
  B-block_TFIIIC  24 LakeskqdprslfyrlksLekkgLIvkqsiidsatkksistsllvlkky 72 
                     +  +++ ++++l +++++L k + Iv +  + +  +k+i+ s+  lk++
      EFC37039.1 368 VNEVTGGKSKKLNKIINALDKTQNIVSVGSNAVDRIKGIKNSIADLKNF 416
                     55678899*******************9999999999999888777776 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.19
  B-block_TFIIIC  12 assRysGitqsdLakeskqdprslfyrlk 40 
                     a++Ry+Gi  s++ k+s++++ +l  +l+
      EFC37039.1 482 AAKRYEGI-KSSIEKLSNMKSGDLKNLLN 509
                     899****8.67899999999999877766 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 5.6
  B-block_TFIIIC  25 akeskqdprslfyrlksLekkgLIv 49 
                      + ++  ++ l +++ +L+k + ++
      EFC37039.1 535 NTFTNGRSKTLVSLVEKLKKGQKVT 559
                     5556666677777777777755444 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.029
  B-block_TFIIIC   8 LelIassRysGi.tqsdLakeskqdprslfyrlksLekkgLIvkqsiidsatkk 60 
                     L ++a +  +G+ + s+L  +s+ + ++l ++l+sL k + I   +   + t+k
      EFC37039.1 600 LNRVAGAFSKGEnIVSELNEISNGKNKNLAKLLQSLRKGQMIANTASSGVGTYK 653
                     55666666667624688999999***************9999887765555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (767 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1351  (0.0753528); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.85u 0.31s 00:00:01.15 Elapsed: 00:00:00.51
# Mc/sec: 4523.95
//
Query:       EFC37040.1  [L=474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 2975.20
//
Query:       EFC37041.1  [L=320]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       925  (0.0515924); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2056.96
//
Query:       EFC37042.1  [L=551]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.74   10.6   6.8        1.8    9.4   2.5    2.8  3  Rxt3      Histone deacetylation protein Rxt3


Domain annotation for each model (and alignments):
>> Rxt3  Histone deacetylation protein Rxt3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.025   4.4e+02      42      86 ..     206     258 ..     197     276 .. 0.56
   2 ?    0.5   0.2     0.055   9.8e+02      58      90 ..     401     433 ..     383     440 .. 0.49
   3 ?    9.4   2.5   9.9e-05       1.8      11      80 ..     429     510 ..     424     531 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.025
        Rxt3  42 sGfirgewaedvdvslldl...........akkkakkkskeekskdeseaekklek 86 
                 sGfi   +  dvdv  ++            +   ++++++ ++s++++ +++++++
  EFC37042.1 206 SGFIPEMYHADVDVIPKNEtcgsplssssaS---NSAANSINNSSTNNVNNTSNNN 258
                 7888888888888877666777776543221...2222222222222222222222 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.055
        Rxt3  58 ldlakkkakkkskeekskdeseaekklekkkkr 90 
                 +++ k+++++k++++++++ +++ekk +kkkk+
  EFC37042.1 401 TTVIKRDTNNKRASRSKAKPTTEEKKGRKKKKN 433
                 334444444444344444444444443333333 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 9.9e-05
        Rxt3  11 eskreeivarrelWGtdvYtdDSDvvaaliHsGfirgewaedvdvslldl............akkkakkkskeekskdesea 80 
                 ++k++e +a++++    + t DS  v++     ++r++  ++++++  +              ++ +++k++ +k+k++s++
  EFC37042.1 429 KKKKNESCASKKVCFLRIVTPDSSFVLVRSDNLWVRSKTRQEMERKKDRAmaqkrkkeeskpVEDYQEEKESPKKKKKTSSK 510
                 4567999999999999*******************99998888877666544444443333311111111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (551 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2389  (0.133248); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        92  (0.00513135); expected 17.9 (0.001)
Passed Fwd filter:                        29  (0.00161749); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.24s 00:00:00.88 Elapsed: 00:00:00.42
# Mc/sec: 3958.59
//
Query:       EFC37043.1  [L=738]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.2e-92  298.5  55.2      2e-09   36.9   0.8   18.1 18  TPR_1       Tetratricopeptide repeat
    5.9e-83  266.5  43.4    6.6e-06   25.8   1.6   18.1 18  TPR_2       Tetratricopeptide repeat
    4.9e-63  208.6  34.8    1.2e-09   37.7   0.0   16.8 18  TPR_11      TPR repeat
      1e-56  184.5  44.3    0.00026   20.9   0.3   17.4 17  TPR_8       Tetratricopeptide repeat
    5.3e-45  151.8   0.4      9e-07   29.5   0.5   10.0 12  TPR_16      Tetratricopeptide repeat
    3.5e-36  123.3  23.6    5.2e-06   26.7   0.1   12.9 13  TPR_12      Tetratricopeptide repeat
    1.1e-35  119.5  25.8    0.00053   20.2   0.2   14.8 16  TPR_17      Tetratricopeptide repeat
    4.2e-31  106.9   0.7    0.00049   20.2   0.0   11.1 12  TPR_9       Tetratricopeptide repeat
    2.5e-20   72.7   3.8      0.076   13.5   0.1    8.1  8  TPR_19      Tetratricopeptide repeat
    3.3e-18   65.0  25.9        4.2    8.2   0.2   15.1 14  TPR_6       Tetratricopeptide repeat
      5e-16   58.0   5.3       0.22   12.5   0.0   10.8 13  TPR_14      Tetratricopeptide repeat
    7.8e-16   58.1  27.5    0.00012   22.2   1.4    8.1  9  ANAPC3      Anaphase-promoting complex, cyclosome, subunit 3
      5e-13   48.1  16.6        1.6    9.0   0.0   12.6 13  TPR_7       Tetratricopeptide repeat
    4.1e-12   45.4  25.2        0.4   10.2   0.1   11.5 12  SHNi-TPR    SHNi-TPR
    2.2e-07   30.4   3.9        2.6    7.2   0.0    6.7  7  TPR_15      Tetratricopeptide repeat
    2.8e-07   30.2  30.6       0.13   12.2   0.0   12.1 15  TPR_10      Tetratricopeptide repeat
    7.6e-07   28.5   9.4     0.0042   16.1   0.0    5.2  5  Paf67       RNA polymerase I-associated factor PAF67
    9.2e-05   22.5   9.1        2.1    8.4   0.0    7.1  7  DUF3856     Domain of Unknown Function (DUF3856)
    0.00024   21.4  12.8        1.4    9.3   0.0    6.2  9  TPR_20      Tetratricopeptide repeat
     0.0055   16.1   0.5       0.15   11.4   0.0    3.1  3  TPR_MalT    MalT-like TPR region
  ------ inclusion threshold ------
      0.043   14.2   1.5         32    4.9   0.0    4.6  5  BTAD        Bacterial transcriptional activator domain
       0.11   11.4  27.5       0.45    9.4   9.9    5.1  4  NARP1       NMDA receptor-regulated protein 1
       0.22   11.6  15.5        8.6    6.5   0.3    5.5  4  Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
       0.24   11.5  23.7        4.4    7.4   0.1    9.9 12  MIT         MIT (microtubule interacting and transport) domai


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0       0.4     3e+02      15      32 ..      42      59 ..      35      59 .. 0.84
   2 !   18.5   0.0   1.8e-06    0.0013       2      29 ..      62      89 ..      61      93 .. 0.90
   3 !    8.7   0.0    0.0021       1.6       2      30 ..      95     123 ..      94     125 .. 0.91
   4 !   15.7   0.4   1.3e-05    0.0095       3      30 ..     165     192 ..     163     194 .. 0.90
   5 !   23.6   0.0   4.1e-08     3e-05       2      34 .]     202     234 ..     201     234 .. 0.97
   6 !    9.3   0.0    0.0013         1       1      33 [.     235     267 ..     235     268 .. 0.89
   7 !   36.9   0.8   2.7e-12     2e-09       4      34 .]     272     302 ..     270     302 .. 0.96
   8 !   25.6   0.2   9.4e-09     7e-06       3      28 ..     305     330 ..     303     331 .. 0.94
   9 !   25.2   0.2   1.3e-08     1e-05       6      33 ..     342     369 ..     338     370 .. 0.92
  10 !   12.5   0.2   0.00014       0.1       2      31 ..     372     401 ..     371     404 .. 0.91
  11 !   11.5   0.0   0.00027      0.21       3      33 ..     406     436 ..     404     437 .. 0.90
  12 !   14.6   0.0     3e-05     0.022       5      28 ..     442     465 ..     440     468 .. 0.91
  13 !   20.2   0.0     5e-07   0.00038       2      34 .]     473     505 ..     472     505 .. 0.93
  14 !   15.8   0.1   1.2e-05    0.0089       2      31 ..     507     536 ..     506     538 .. 0.91
  15 !   24.6   0.8     2e-08   1.5e-05       1      30 [.     540     569 ..     540     570 .. 0.91
  16 !   20.0   0.1   5.8e-07   0.00043       2      30 ..     591     619 ..     590     622 .. 0.93
  17 !   13.9   0.0     5e-05     0.037       3      34 .]     646     677 ..     644     677 .. 0.92
  18 !   26.0   0.5   7.1e-09   5.3e-06       3      34 .]     680     711 ..     678     711 .. 0.97

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.4
                T-HHHHHHHHHHHHHHST CS
       TPR_1 15 gkydeAleyyekALelnP 32
                + ++eA e+  +A+  +P
  EFC37043.1 42 KLFKEAAEDLTEAINFRP 59
                6799*********97666 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 1.8e-06
                HHHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1  2 kalynlGnayfklgkydeAleyyekALe 29
                k ++ +Gn+y++ ++yd A+ +y  A+ 
  EFC37043.1 62 KFHFLRGNCYRHTQDYDRAILDYTIAID 89
                67999******************98886 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0021
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALel 30 
                   +  +G +++  gk ++ ++++++ + +
  EFC37043.1  95 AFYLARGKCFRTIGKINKSIADFDRGIDI 123
                 56889********************9976 PP

  == domain 4  score: 15.7 bits;  conditional E-value: 1.3e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALel 30 
                  +  +G+ y+++g+ + A+e y kA+  
  EFC37043.1 165 LYVDRGLSYYEKGEKKLAIENYGKAILM 192
                 5788*********************966 PP

  == domain 5  score: 23.6 bits;  conditional E-value: 4.1e-08
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                 ka++ +Gn++++ g++d  +e+  kA  l+P+n
  EFC37043.1 202 KAYFHRGNTLRECGELDASIEDLTKAADLDPKN 234
                 8******************************98 PP

  == domain 6  score: 9.3 bits;  conditional E-value: 0.0013
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   1 akalynlGnayfklgkydeAleyyekALelnPn 33 
                 a +++nlG+ +f++ ++  A++ +   +e +P+
  EFC37043.1 235 AAVHNNLGLSFFEKRNFPGAEKRFTLSIENDPT 267
                 679*****************9988888888886 PP

  == domain 7  score: 36.9 bits;  conditional E-value: 2.7e-12
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   4 lynlGnayfklgkydeAleyyekALelnPnn 34 
                 ++n+G+ay+kl+ +++A+e+++ AL l+P++
  EFC37043.1 272 HNNRGLAYYKLKAFEKAIEDFSCALNLDPDD 302
                 8****************************96 PP

  == domain 8  score: 25.6 bits;  conditional E-value: 9.4e-09
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekAL 28 
                 +++n+Gn+++ +++y+eAl++++ A+
  EFC37043.1 305 IYFNRGNTLLAMKRYEEALQDFNLAI 330
                 7**********************997 PP

  == domain 9  score: 25.2 bits;  conditional E-value: 1.3e-08
                 HHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   6 nlGnayfklgkydeAleyyekALelnPn 33 
                  +G ay+++++  +A++ ++kALe+n++
  EFC37043.1 342 CKGIAYQEMNDIPQAIQMFKKALEINEK 369
                 68************************86 PP

  == domain 10  score: 12.5 bits;  conditional E-value: 0.00014
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALeln 31 
                 ++ly lG++y+ ++++ eA + + kALel 
  EFC37043.1 372 QSLYHLGLMYHINNQLFEAKKQFTKALELV 401
                 689*************************95 PP

  == domain 11  score: 11.5 bits;  conditional E-value: 0.00027
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPn 33 
                 ++  +G++y+ l  y+ A+++++ A+++ P+
  EFC37043.1 406 IYESRGLVYMDLLYYELAIQDFSAAIRIVPD 436
                 56689**********************9887 PP

  == domain 12  score: 14.6 bits;  conditional E-value: 3e-05
                 HHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekAL 28 
                 + +G +++ l++y eA+e+++ A 
  EFC37043.1 442 FHRGKCFLWLERYTEAVEDFNTAF 465
                 789******************996 PP

  == domain 13  score: 20.2 bits;  conditional E-value: 5e-07
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                 ++++ +++ay +l+k+deA+ + + A++ ++nn
  EFC37043.1 473 QVFNARAMAYKHLKKHDEAISDLSSAIKSDENN 505
                 67899***********************99997 PP

  == domain 14  score: 15.8 bits;  conditional E-value: 1.2e-05
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALeln 31 
                 + ++n+ +++f l++y +Al++ +  Le++
  EFC37043.1 507 EYYFNRSQCFFDLKNYRQALKDLDTSLEIE 536
                 67999999********************97 PP

  == domain 15  score: 24.6 bits;  conditional E-value: 2e-08
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayfklgkydeAleyyekALel 30 
                 +k +y +G++y+++++y+ A+++++ AL+l
  EFC37043.1 540 PKLYYLRGLTYYEMKNYKMAIKDFKGALRL 569
                 589*********************988876 PP

  == domain 16  score: 20.0 bits;  conditional E-value: 5.8e-07
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALel 30 
                 +++y +G++y  l+ky+ A+e ++kA+ l
  EFC37043.1 591 DCFYHMGLCYCFLEKYEYAVESFSKAVDL 619
                 689***********************987 PP

  == domain 17  score: 13.9 bits;  conditional E-value: 5e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                  +  ++ ay+  g+ + Ale++  +++ +P+n
  EFC37043.1 646 YHHERAKAYQIIGMNERALEDFTTVIKYQPDN 677
                 57789*************************98 PP

  == domain 18  score: 26.0 bits;  conditional E-value: 7.1e-09
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 a+++++ a   l++++eA e++ekA +l+Pnn
  EFC37043.1 680 AYFRRAFAWKALERFEEAAEDFEKAKSLQPNN 711
                 9******************************8 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.55   4.1e+02      17      32 ..      44      59 ..      38      60 .. 0.85
   2 !   17.3   0.0   4.9e-06    0.0037       2      28 ..      62      88 ..      61      93 .. 0.90
   3 ?    3.7   0.0      0.11        80       1      29 [.      94     122 ..      94     125 .. 0.90
   4 !   13.7   0.3   6.8e-05     0.051       3      30 ..     165     192 ..     163     193 .. 0.90
   5 !   19.4   0.0     1e-06   0.00077       2      34 .]     202     234 ..     201     234 .. 0.97
   6 !   11.7   0.0    0.0003      0.23       1      33 [.     235     267 ..     235     268 .. 0.95
   7 !   25.2   0.3   1.5e-08   1.1e-05       3      34 .]     271     302 ..     269     302 .. 0.96
   8 !   20.9   0.0   3.5e-07   0.00026       3      29 ..     305     331 ..     303     336 .. 0.91
   9 !   16.8   0.0   7.2e-06    0.0054       4      33 ..     340     369 ..     338     370 .. 0.92
  10 !   16.6   0.2     8e-06     0.006       3      31 ..     373     401 ..     371     404 .. 0.91
  11 !   13.8   0.0   6.1e-05     0.046       3      33 ..     406     436 ..     404     437 .. 0.92
  12 !   11.5   0.0   0.00035      0.26       4      29 ..     441     466 ..     438     471 .. 0.90
  13 !   15.1   0.0   2.4e-05     0.018       2      34 .]     473     505 ..     472     505 .. 0.93
  14 !   18.5   0.0   1.9e-06    0.0014       2      31 ..     507     536 ..     506     538 .. 0.94
  15 !   22.3   0.3   1.2e-07   8.8e-05       1      30 [.     540     569 ..     540     571 .. 0.94
  16 !   12.8   0.0   0.00014       0.1       3      30 ..     592     619 ..     590     622 .. 0.92
  17 !   14.1   0.0   5.2e-05     0.039       2      34 .]     645     677 ..     644     677 .. 0.95
  18 !   25.8   1.6   8.9e-09   6.6e-06       1      34 []     678     711 ..     678     711 .. 0.96

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.55
       TPR_2 17 yeeAleafekAleldP 32
                ++eA+e++ +A+   P
  EFC37043.1 44 FKEAAEDLTEAINFRP 59
                79*********98666 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 4.9e-06
       TPR_2  2 ealynlGlayyklgdyeeAleafekAl 28
                + ++ +G++y++ +dy++A+ ++  A+
  EFC37043.1 62 KFHFLRGNCYRHTQDYDRAILDYTIAI 88
                78********************98877 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.11
       TPR_2   1 aealynlGlayyklgdyeeAleafekAle 29 
                 a  + ++G++ +  g+ ++ +++f++ + 
  EFC37043.1  94 AAFYLARGKCFRTIGKINKSIADFDRGID 122
                 567999*******************9886 PP

  == domain 4  score: 13.7 bits;  conditional E-value: 6.8e-05
       TPR_2   3 alynlGlayyklgdyeeAleafekAlel 30 
                 ++  +Gl+yy++g+ + A+e + kA+  
  EFC37043.1 165 LYVDRGLSYYEKGEKKLAIENYGKAILM 192
                 6889*********************965 PP

  == domain 5  score: 19.4 bits;  conditional E-value: 1e-06
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                 +a++ +G+ +++ g+++  +e++ kA  ldP+n
  EFC37043.1 202 KAYFHRGNTLRECGELDASIEDLTKAADLDPKN 234
                 79*****************************97 PP

  == domain 6  score: 11.7 bits;  conditional E-value: 0.0003
       TPR_2   1 aealynlGlayyklgdyeeAleafekAleldPn 33 
                 a +++nlGl+ +++ ++  A++ f  ++e dP+
  EFC37043.1 235 AAVHNNLGLSFFEKRNFPGAEKRFTLSIENDPT 267
                 679****************************97 PP

  == domain 7  score: 25.2 bits;  conditional E-value: 1.5e-08
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPnn 34 
                 +++n+Glayykl+ +e+A+e+f  Al ldP++
  EFC37043.1 271 YHNNRGLAYYKLKAFEKAIEDFSCALNLDPDD 302
                 89****************************97 PP

  == domain 8  score: 20.9 bits;  conditional E-value: 3.5e-07
       TPR_2   3 alynlGlayyklgdyeeAleafekAle 29 
                 +++n+G+ ++++++yeeAl++f+ A+ 
  EFC37043.1 305 IYFNRGNTLLAMKRYEEALQDFNLAIN 331
                 79*********************9986 PP

  == domain 9  score: 16.8 bits;  conditional E-value: 7.2e-06
       TPR_2   4 lynlGlayyklgdyeeAleafekAleldPn 33 
                  ++ G ay +++d  +A++ f+kAle++++
  EFC37043.1 340 FHCKGIAYQEMNDIPQAIQMFKKALEINEK 369
                 6899***********************976 PP

  == domain 10  score: 16.6 bits;  conditional E-value: 8e-06
       TPR_2   3 alynlGlayyklgdyeeAleafekAleld 31 
                  ly lGl y  ++++ eA++ f kAlel 
  EFC37043.1 373 SLYHLGLMYHINNQLFEAKKQFTKALELV 401
                 69*************************95 PP

  == domain 11  score: 13.8 bits;  conditional E-value: 6.1e-05
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPn 33 
                 ++  +Gl+y+ l  ye A+++f +A+++ P+
  EFC37043.1 406 IYESRGLVYMDLLYYELAIQDFSAAIRIVPD 436
                 67789***********************998 PP

  == domain 12  score: 11.5 bits;  conditional E-value: 0.00035
       TPR_2   4 lynlGlayyklgdyeeAleafekAle 29 
                  + +G++ + l +y eA+e+f+ A +
  EFC37043.1 441 FFHRGKCFLWLERYTEAVEDFNTAFK 466
                 689********************987 PP

  == domain 13  score: 15.1 bits;  conditional E-value: 2.4e-05
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                 ++ +++++ay +l++++eA+ ++  A++ d+nn
  EFC37043.1 473 QVFNARAMAYKHLKKHDEAISDLSSAIKSDENN 505
                 57899***********************99997 PP

  == domain 14  score: 18.5 bits;  conditional E-value: 1.9e-06
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleld 31 
                 e+++n+ ++ + l++y +Al++++ +le++
  EFC37043.1 507 EYYFNRSQCFFDLKNYRQALKDLDTSLEIE 536
                 89*************************986 PP

  == domain 15  score: 22.3 bits;  conditional E-value: 1.2e-07
       TPR_2   1 aealynlGlayyklgdyeeAleafekAlel 30 
                 ++++y +Gl yy++++y+ A+++f+ Al+l
  EFC37043.1 540 PKLYYLRGLTYYEMKNYKMAIKDFKGALRL 569
                 579*************************98 PP

  == domain 16  score: 12.8 bits;  conditional E-value: 0.00014
       TPR_2   3 alynlGlayyklgdyeeAleafekAlel 30 
                 + y +Gl+y  l +ye A+e f kA+ l
  EFC37043.1 592 CFYHMGLCYCFLEKYEYAVESFSKAVDL 619
                 789**********************987 PP

  == domain 17  score: 14.1 bits;  conditional E-value: 5.2e-05
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                  +++++++ay   g  e+Ale+f  ++++ P+n
  EFC37043.1 645 VYHHERAKAYQIIGMNERALEDFTTVIKYQPDN 677
                 589****************************98 PP

  == domain 18  score: 25.8 bits;  conditional E-value: 8.9e-09
       TPR_2   1 aealynlGlayyklgdyeeAleafekAleldPnn 34 
                 a a+++++ a+ +l ++eeA+e+fekA +l Pnn
  EFC37043.1 678 AHAYFRRAFAWKALERFEEAAEDFEKAKSLQPNN 711
                 579*****************************98 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.29   2.2e+02      11      36 ..      45      69 ..      44      71 .. 0.83
   2 ?    3.9   0.1     0.057        43       1      34 [.      68     100 ..      68     108 .. 0.78
   3 ?   -0.5   0.0       1.4     1e+03       4      23 ..     104     123 ..     101     123 .. 0.82
   4 !   11.7   0.4   0.00022      0.16       1      21 [.     170     190 ..     170     193 .. 0.95
   5 !   37.7   0.0   1.6e-12   1.2e-09       1      40 [.     208     247 ..     208     248 .. 0.97
   6 !    7.9   0.2    0.0031       2.3      24      41 ..     265     282 ..     261     283 .. 0.84
   7 !   34.2   0.2     2e-11   1.5e-08       1      40 [.     276     315 ..     276     317 .. 0.95
   8 !   15.0   0.2   1.9e-05     0.014       1      41 [.     310     350 ..     310     351 .. 0.96
   9 !   22.8   0.1   7.2e-08   5.4e-05       4      39 ..     347     382 ..     346     385 .. 0.94
  10 !    6.6   0.0    0.0081         6       1      40 [.     378     416 ..     378     417 .. 0.91
  11 !   16.2   0.0   8.3e-06    0.0062       3      36 ..     413     446 ..     411     449 .. 0.86
  12 !   10.1   0.0   0.00069      0.51       8      39 ..     452     483 ..     450     486 .. 0.93
  13 !   16.3   0.2   7.7e-06    0.0057       4      34 ..     482     512 ..     481     517 .. 0.90
  14 !   21.5   0.2   1.8e-07   0.00013       4      41 ..     516     553 ..     514     554 .. 0.96
  15 !    7.5   0.0    0.0044       3.3       1      24 [.     547     570 ..     547     572 .. 0.94
  16 !    7.2   0.0    0.0052       3.9       5      32 ..     601     628 ..     597     629 .. 0.86
  17 !   14.9   0.0   2.2e-05     0.016       7      37 ..     657     687 ..     651     691 .. 0.87
  18 !   10.8   0.1    0.0004       0.3       7      30 ..     691     714 ..     688     717 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.29
      TPR_11 11 eeAieaYkkAlkldPdnaeayynLGl 36
                +eA e++ +A++++P  + +++ +G+
  EFC37043.1 45 KEAAEDLTEAINFRP-LPKFHFLRGN 69
                79***********99.7888888887 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.057
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynL 34 
                 G+ y+  ++y+ Ai +Y  A++  +  a +y+++
  EFC37043.1  68 GNCYRHTQDYDRAILDYTIAIDTQE-EAAFYLAR 100
                 889999***********99998443.34455555 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 1.4
      TPR_11   4 yyeqGkyeeAieaYkkAlkl 23 
                 ++  Gk++++i+++ + +++
  EFC37043.1 104 FRTIGKINKSIADFDRGIDI 123
                 6667*********9999876 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 0.00022
      TPR_11   1 GdayyeqGkyeeAieaYkkAl 21 
                 G  yye+G+ + Aie+Y kA+
  EFC37043.1 170 GLSYYEKGEKKLAIENYGKAI 190
                 789*****************8 PP

  == domain 5  score: 37.7 bits;  conditional E-value: 1.6e-12
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40 
                 G+ ++e G+++++ie++ kA +ldP+na +++nLGl +++
  EFC37043.1 208 GNTLRECGELDASIEDLTKAADLDPKNAAVHNNLGLSFFE 247
                 9***********************************9987 PP

  == domain 6  score: 7.9 bits;  conditional E-value: 0.0031
      TPR_11  24 dPdnaeayynLGlayykq 41 
                 dP+    ++n+Glayyk+
  EFC37043.1 265 DPTKGIYHNNRGLAYYKL 282
                 7778889*********97 PP

  == domain 7  score: 34.2 bits;  conditional E-value: 2e-11
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40 
                 G ayy++  +e+Aie+++ Al+ldPd+ ++y+n+G+++++
  EFC37043.1 276 GLAYYKLKAFEKAIEDFSCALNLDPDDGNIYFNRGNTLLA 315
                 89**********************************9876 PP

  == domain 8  score: 15.0 bits;  conditional E-value: 1.9e-05
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayykq 41 
                 G+ + +  +yeeA+++++ A++   ++ + +++ G ay+++
  EFC37043.1 310 GNTLLAMKRYEEALQDFNLAINKVDTDENYFHCKGIAYQEM 350
                 89999*********************************987 PP

  == domain 9  score: 22.8 bits;  conditional E-value: 7.2e-08
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 y e +++++Ai+ +kkAl+++++++  +y+LGl y+
  EFC37043.1 347 YQEMNDIPQAIQMFKKALEINEKSVQSLYHLGLMYH 382
                 77899****************************998 PP

  == domain 10  score: 6.6 bits;  conditional E-value: 0.0081
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40 
                 G +y+  +++ eA +++ kAl+l  d  ++y  +Gl+y+ 
  EFC37043.1 378 GLMYHINNQLFEAKKQFTKALELVHDH-RIYESRGLVYMD 416
                 889*********************985.999999999975 PP

  == domain 11  score: 16.2 bits;  conditional E-value: 8.3e-06
      TPR_11   3 ayyeqGkyeeAieaYkkAlkldPdnaeayynLGl 36 
                 +y+++  ye Ai+++++A+++ Pd+++ ++++G+
  EFC37043.1 413 VYMDLLYYELAIQDFSAAIRIVPDSPNNFFHRGK 446
                 56666669************************98 PP

  == domain 12  score: 10.1 bits;  conditional E-value: 0.00069
      TPR_11   8 GkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                  +y+eA+e++++A k   d++ ++++++ ay 
  EFC37043.1 452 ERYTEAVEDFNTAFKQHCDDPQVFNARAMAYK 483
                 58**************************9996 PP

  == domain 13  score: 16.3 bits;  conditional E-value: 7.7e-06
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdnaeayynL 34 
                 y  + k +eAi +++ A+k d++n+e y+n+
  EFC37043.1 482 YKHLKKHDEAISDLSSAIKSDENNVEYYFNR 512
                 6667899**********************97 PP

  == domain 14  score: 21.5 bits;  conditional E-value: 1.8e-07
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlayykq 41 
                 ++++ +y +A++++ + l++  + + +yy +Gl+yy++
  EFC37043.1 516 FFDLKNYRQALKDLDTSLEIEKSEPKLYYLRGLTYYEM 553
                 7999********************************97 PP

  == domain 15  score: 7.5 bits;  conditional E-value: 0.0044
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkld 24 
                 G  yye  +y+ Ai+++k Al+l+
  EFC37043.1 547 GLTYYEMKNYKMAIKDFKGALRLK 570
                 789*******************97 PP

  == domain 16  score: 7.2 bits;  conditional E-value: 0.0052
      TPR_11   5 yeqGkyeeAieaYkkAlkldPdnaeayy 32 
                 + + kye A+e+++kA++l +d  +++ 
  EFC37043.1 601 CFLEKYEYAVESFSKAVDLISDKENVHT 628
                 55789**************999999985 PP

  == domain 17  score: 14.9 bits;  conditional E-value: 2.2e-05
      TPR_11   7 qGkyeeAieaYkkAlkldPdnaeayynLGla 37 
                  G +e A+e++ + +k+ Pdna ay+ +++a
  EFC37043.1 657 IGMNERALEDFTTVIKYQPDNAHAYFRRAFA 687
                 67799**********************9987 PP

  == domain 18  score: 10.8 bits;  conditional E-value: 0.0004
      TPR_11   7 qGkyeeAieaYkkAlkldPdnaea 30 
                 + ++eeA e+++kA  l P+n+++
  EFC37043.1 691 LERFEEAAEDFEKAKSLQPNNPNL 714
                 6799******************85 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1         1   7.5e+02      10      32 ..      37      59 ..      35      59 .. 0.83
   2 !    7.5   0.0    0.0071       5.3       3      25 ..      63      85 ..      61      93 .. 0.85
   3 ?    4.3   0.0     0.075        56       3      30 ..      96     123 ..      94     123 .. 0.90
   4 !   12.0   0.6   0.00027       0.2       2      30 ..     164     192 ..     163     193 .. 0.92
   5 !   20.0   0.0     7e-07   0.00052       2      34 .]     202     234 ..     201     234 .. 0.97
   6 !   15.6   0.2   1.8e-05     0.014       4      34 .]     272     302 ..     271     302 .. 0.95
   7 !   16.2   0.1   1.2e-05    0.0086       3      28 ..     305     330 ..     303     331 .. 0.94
   8 !   13.7   0.1   7.5e-05     0.056       8      33 ..     344     369 ..     340     370 .. 0.93
   9 !   11.8   0.1    0.0003      0.23       2      30 ..     372     400 ..     371     400 .. 0.96
  10 !    9.9   0.0    0.0012      0.91       2      31 ..     405     434 ..     404     437 .. 0.90
  11 ?    3.3   0.0      0.16   1.2e+02       7      29 ..     444     466 ..     440     467 .. 0.80
  12 !   16.3   0.0   1.1e-05    0.0082       2      34 .]     473     505 ..     472     505 .. 0.92
  13 !   13.8   0.1   6.8e-05     0.051       2      32 ..     507     537 ..     506     539 .. 0.94
  14 !   20.9   0.3   3.5e-07   0.00026       2      31 ..     541     570 ..     540     572 .. 0.94
  15 !    8.9   0.1    0.0025       1.9       3      31 ..     592     620 ..     590     623 .. 0.90
  16 !    9.0   0.0    0.0024       1.8       4      34 .]     647     677 ..     644     677 .. 0.92
  17 !   17.3   0.2   5.3e-06     0.004       1      34 []     678     711 ..     678     711 .. 0.95

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 1
                HHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8 10 iylklgdyeeAkeyyekaleldp 32
                + l+++ ++eA e + +a+  +p
  EFC37043.1 37 TKLTKKLFKEAAEDLTEAINFRP 59
                56788999**********98776 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0071
                HHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_8  3 ayynlgsiylklgdyeeAkeyye 25
                 +++ g++y+ ++dy+ A+  y 
  EFC37043.1 63 FHFLRGNCYRHTQDYDRAILDYT 85
                6899***************8886 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.075
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekalel 30 
                  y+  g++ ++ g+++++++ + + +++
  EFC37043.1  96 FYLARGKCFRTIGKINKSIADFDRGIDI 123
                 7999******************998875 PP

  == domain 4  score: 12.0 bits;  conditional E-value: 0.00027
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekalel 30 
                 ++y+  g+ y ++g+++ A+e y ka+ +
  EFC37043.1 164 QLYVDRGLSYYEKGEKKLAIENYGKAILM 192
                 6899**********************976 PP

  == domain 5  score: 20.0 bits;  conditional E-value: 7e-07
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleldpdn 34 
                 +ay++ g+++++ g++++++e + ka +ldp+n
  EFC37043.1 202 KAYFHRGNTLRECGELDASIEDLTKAADLDPKN 234
                 79*****************************97 PP

  == domain 6  score: 15.6 bits;  conditional E-value: 1.8e-05
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekaleldpdn 34 
                 ++n g++y kl+ +e+A+e +  al ldpd+
  EFC37043.1 272 HNNRGLAYYKLKAFEKAIEDFSCALNLDPDD 302
                 689**************************96 PP

  == domain 7  score: 16.2 bits;  conditional E-value: 1.2e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekal 28 
                 +y+n g+++l +++yeeA + ++ a+
  EFC37043.1 305 IYFNRGNTLLAMKRYEEALQDFNLAI 330
                 8**********************998 PP

  == domain 8  score: 13.7 bits;  conditional E-value: 7.5e-05
                 HHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   8 gsiylklgdyeeAkeyyekaleldpd 33 
                 g +y++++d+ +A++ ++kale++++
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALEINEK 369
                 779********************987 PP

  == domain 9  score: 11.8 bits;  conditional E-value: 0.0003
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekalel 30 
                 +++y+lg+ y+  +++ eAk+ + kalel
  EFC37043.1 372 QSLYHLGLMYHINNQLFEAKKQFTKALEL 400
                 799************************97 PP

  == domain 10  score: 9.9 bits;  conditional E-value: 0.0012
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleld 31 
                 ++y   g++y++l  ye A++ +  a+++ 
  EFC37043.1 405 RIYESRGLVYMDLLYYELAIQDFSAAIRIV 434
                 789999*********************985 PP

  == domain 11  score: 3.3 bits;  conditional E-value: 0.16
                 HHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   7 lgsiylklgdyeeAkeyyekale 29 
                  g++ l l++y eA+e ++ a +
  EFC37043.1 444 RGKCFLWLERYTEAVEDFNTAFK 466
                 566666699**********9965 PP

  == domain 12  score: 16.3 bits;  conditional E-value: 1.1e-05
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleldpdn 34 
                 ++ +  +++y+ l++++eA++ +  a++ d++n
  EFC37043.1 473 QVFNARAMAYKHLKKHDEAISDLSSAIKSDENN 505
                 577899************************986 PP

  == domain 13  score: 13.8 bits;  conditional E-value: 6.8e-05
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleldp 32 
                 e+y+n +++ ++l++y +A + +   le+++
  EFC37043.1 507 EYYFNRSQCFFDLKNYRQALKDLDTSLEIEK 537
                 89**************************987 PP

  == domain 14  score: 20.9 bits;  conditional E-value: 3.5e-07
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleld 31 
                 ++yy+ g++y ++++y++A++ ++ al+l+
  EFC37043.1 541 KLYYLRGLTYYEMKNYKMAIKDFKGALRLK 570
                 78*************************997 PP

  == domain 15  score: 8.9 bits;  conditional E-value: 0.0025
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleld 31 
                   y++g++y  l++ye A+e++ ka++l 
  EFC37043.1 592 CFYHMGLCYCFLEKYEYAVESFSKAVDLI 620
                 6799**********************985 PP

  == domain 16  score: 9.0 bits;  conditional E-value: 0.0024
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekaleldpdn 34 
                 ++  +++y+  g  e A e +  +++++pdn
  EFC37043.1 647 HHERAKAYQIIGMNERALEDFTTVIKYQPDN 677
                 67789************************97 PP

  == domain 17  score: 17.3 bits;  conditional E-value: 5.3e-06
                 CCHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   1 aeayynlgsiylklgdyeeAkeyyekaleldpdn 34 
                 a+ay++ + + + l+++eeA e +eka +l+p+n
  EFC37043.1 678 AHAYFRRAFAWKALERFEEAAEDFEKAKSLQPNN 711
                 689*****************************97 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.0   9.8e-05     0.073      14      62 ..      45      89 ..      35      95 .. 0.80
   2 !    8.3   0.0    0.0047       3.5      11      44 ..      75     104 ..      65     123 .. 0.55
   3 ?    2.0   0.0      0.46   3.4e+02      35      55 ..     164     185 ..     158     192 .. 0.82
   4 !   11.8   0.0   0.00039      0.29       2      67 ..     168     234 ..     167     235 .. 0.85
   5 !   17.1   0.0   8.8e-06    0.0066       5      65 ..     209     266 ..     205     268 .. 0.84
   6 !   22.1   0.0   2.4e-07   0.00018       2      61 ..     274     330 ..     273     337 .. 0.92
   7 !   14.2   0.0   7.2e-05     0.054       4      60 ..     344     397 ..     343     401 .. 0.86
   8 ?    5.0   0.0     0.054        40      15      68 .]     389     438 ..     385     438 .. 0.87
   9 !    9.9   0.0    0.0015       1.1       4      60 ..     411     464 ..     408     471 .. 0.87
  10 !   16.5   0.0   1.3e-05      0.01      11      63 ..     452     501 ..     444     506 .. 0.89
  11 !   17.2   0.0   7.8e-06    0.0058       7      63 ..     516     569 ..     510     573 .. 0.92
  12 !   29.5   0.5   1.2e-09     9e-07      13      68 .]     660     712 ..     649     712 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 9.8e-05
      TPR_16 14 ddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalr 62
                 +Aa+ l++a+  +   P  + +++l+g+++ + +++++A+  y  a++
  EFC37043.1 45 KEAAEDLTEAINFR---P-LPKFHFLRGNCYRHTQDYDRAILDYTIAID 89
                56777777777666...6.799*******************88877765 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0047
      TPR_16  11 gdyddAaaaleaalkrdpssPdaaeAllllgdaa 44 
                 +dyd+A+  +++a++ +    + a+++l++g ++
  EFC37043.1  75 QDYDRAILDYTIAIDTQ----EEAAFYLARGKCF 104
                 45555555555555555....2455555555555 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.46
      TPR_16  35 eAllllgdaalrqgrlaeAa.a 55 
                 + +  +g++++++g+ ++A+  
  EFC37043.1 164 QLYVDRGLSYYEKGEKKLAIeN 185
                 678899************9944 PP

  == domain 4  score: 11.8 bits;  conditional E-value: 0.00039
      TPR_16   2 alaraalragdyddAaaal.eaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapda 67 
                 ++++++++ g+   A++ + +a l +  +      A++++g+ + + g+l++ ++ + +a++ +p++
  EFC37043.1 168 DRGLSYYEKGEKKLAIENYgKAILMNVTKQQSLFKAYFHRGNTLRECGELDASIEDLTKAADLDPKN 234
                 6799999************5555555555566**********************8888888***987 PP

  == domain 5  score: 17.1 bits;  conditional E-value: 8.8e-06
      TPR_16   5 raalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraap 65 
                 + +++ g+ d+ ++ l+ a ++d   P +a+ +++lg++++++ ++++A+  +   ++++p
  EFC37043.1 209 NTLRECGELDASIEDLTKAADLD---PKNAAVHNNLGLSFFEKRNFPGAEKRFTLSIENDP 266
                 55666688999999999999999...************************65555557777 PP

  == domain 6  score: 22.1 bits;  conditional E-value: 2.4e-07
      TPR_16   2 alaraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraal 61 
                 ++++a+++++ +++A++ +  al +d   Pd+   ++++g+ +l+ +r++eA++ ++ a+
  EFC37043.1 274 NRGLAYYKLKAFEKAIEDFSCALNLD---PDDGNIYFNRGNTLLAMKRYEEALQDFNLAI 330
                 5799**********************...************************8887775 PP

  == domain 7  score: 14.2 bits;  conditional E-value: 7.2e-05
      TPR_16   4 araalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraa 60 
                 + a+ + +d ++A+ +++ al+ +      +++l++lg+++  ++ l eA  ++ +a
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALEIN---EKSVQSLYHLGLMYHINNQLFEAKKQFTKA 397
                 789*********************...**************9988776665555555 PP

  == domain 8  score: 5.0 bits;  conditional E-value: 0.054
      TPR_16  15 dAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapdap 68 
                 +A ++++ al++      +++ +  +g+++  +  +++A++ + aa+r  pd+p
  EFC37043.1 389 EAKKQFTKALELV----HDHRIYESRGLVYMDLLYYELAIQDFSAAIRIVPDSP 438
                 5788888888888....489999999999999999999**99999999999987 PP

  == domain 9  score: 9.9 bits;  conditional E-value: 0.0015
      TPR_16   4 araalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraa 60 
                 ++ ++++  y+ A+  + aa++     Pd +   +++g ++l + r++eA++ ++ a
  EFC37043.1 411 GLVYMDLLYYELAIQDFSAAIRIV---PDSPNNFFHRGKCFLWLERYTEAVEDFNTA 464
                 677888888***************...99999*******************655544 PP

  == domain 10  score: 16.5 bits;  conditional E-value: 1.3e-05
      TPR_16  11 gdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalra 63 
                  +y++A++ +++a k++    d+++  ++++ a+ +++ ++eA+  + +a++ 
  EFC37043.1 452 ERYTEAVEDFNTAFKQH---CDDPQVFNARAMAYKHLKKHDEAISDLSSAIKS 501
                 69***************...88888*******************777777655 PP

  == domain 11  score: 17.2 bits;  conditional E-value: 7.8e-06
      TPR_16   7 alragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalra 63 
                 ++++++y++A++ l++ l+  +s+P     ++l+g+ +++ ++++ A+  ++ alr 
  EFC37043.1 516 FFDLKNYRQALKDLDTSLEIEKSEPK---LYYLRGLTYYEMKNYKMAIKDFKGALRL 569
                 6899*****************98888...*******************999888865 PP

  == domain 12  score: 29.5 bits;  conditional E-value: 1.2e-09
      TPR_16  13 yddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapdap 68 
                  ++A++ +++++k++   Pd+a+A++ ++ a+ ++ r++eAa+ +++a    p++p
  EFC37043.1 660 NERALEDFTTVIKYQ---PDNAHAYFRRAFAWKALERFEEAAEDFEKAKSLQPNNP 712
                 589************...******************************99999887 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.0   0.00053       0.4       9      62 ..      67     118 ..      63     126 .. 0.82
   2 ?    1.6   0.0      0.45   3.3e+02      46      71 ..     164     189 ..     151     192 .. 0.81
   3 !   11.9   0.0   0.00028      0.21       4      74 ..     202     264 ..     199     267 .. 0.89
   4 !   26.7   0.1   6.9e-09   5.2e-06       6      72 ..     272     330 ..     268     332 .. 0.91
   5 !   13.9   0.0   6.5e-05     0.049      52      77 .]     344     369 ..     338     369 .. 0.90
   6 !    8.9   0.6    0.0024       1.8       5      41 ..     373     404 ..     370     436 .. 0.72
   7 ?    6.0   0.0      0.02        15       8      29 ..     443     464 ..     402     466 .. 0.58
   8 !   14.1   0.1   5.7e-05     0.042       9      72 ..     444     499 ..     437     503 .. 0.88
   9 !   19.0   0.1   1.7e-06    0.0013       6      74 ..     475     535 ..     470     538 .. 0.87
  10 !   19.3   0.2   1.3e-06     0.001       8      75 ..     511     570 ..     502     571 .. 0.90
  11 !    8.6   0.0     0.003       2.2       7      36 ..     594     623 ..     591     636 .. 0.83
  12 ?    2.2   0.0       0.3   2.2e+02      39      71 ..     638     670 ..     629     676 .. 0.77
  13 ?    4.4   0.2     0.062        47       9      45 ..     684     715 ..     676     721 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00053
      TPR_12   9 laavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgrye 62 
                 +++++r+ ++yd A+  +  a++ ++++    +++   + r++g +     +++
  EFC37043.1  67 RGNCYRHTQDYDRAILDYTIAIDTQEEA--AFYLARGKCFRTIGKINKSIADFD 118
                 79*******************9999888..888888888888887766655555 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.45
      TPR_12  46 ttlrnLgrlyralgryeeAlelleea 71 
                 + + + g  y++ g+ + A+e + +a
  EFC37043.1 164 QLYVDRGLSYYEKGEKKLAIENYGKA 189
                 67888899999999999999999887 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 0.00028
      TPR_12   4 talnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                 +a+ +++++lr+ g++d ++e l ka ++      p++   a++ +nLg  +++  ++  A+++++ +++ 
  EFC37043.1 202 KAYFHRGNTLRECGELDASIEDLTKAADLD-----PKN---AAVHNNLGLSFFEKRNFPGAEKRFTLSIEN 264
                 577789********************8888.....876...99*********************9988775 PP

  == domain 4  score: 26.7 bits;  conditional E-value: 6.9e-09
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72 
                 +nn+++++++l+ +++A+e +  al++      pd     ++++n g +++a++ryeeAl+ ++ a+
  EFC37043.1 272 HNNRGLAYYKLKAFEKAIEDFSCALNLD-----PDD---GNIYFNRGNTLLAMKRYEEALQDFNLAI 330
                 347*************************.....986...89********************998775 PP

  == domain 5  score: 13.9 bits;  conditional E-value: 6.5e-05
      TPR_12  52 grlyralgryeeAlelleealaiaek 77 
                 g++y+++++  +A++++++al+i ek
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALEINEK 369
                 8899999*************999875 PP

  == domain 6  score: 8.9 bits;  conditional E-value: 0.0024
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleiarrllGpdh 41 
                 +l++l+++++   ++ eA + + kale++     +dh
  EFC37043.1 373 SLYHLGLMYHINNQLFEAKKQFTKALELV-----HDH 404
                 45699999999999999999999999998.....556 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.02
      TPR_12   8 nlaavlrrlgrydeAlelleka 29 
                 +++ + ++l+ry+eA e +++a
  EFC37043.1 443 HRGKCFLWLERYTEAVEDFNTA 464
                 3455555666666666665555 PP

  == domain 8  score: 14.1 bits;  conditional E-value: 5.7e-05
      TPR_12   9 laavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72 
                 ++ + ++l+ry+eA e +++a  ++     +d p+   + ++ +++y  l++++eA++ l  a+
  EFC37043.1 444 RGKCFLWLERYTEAVEDFNTAFKQH-----CDDPQ---VFNARAMAYKHLKKHDEAISDLSSAI 499
                 788999***************9999.....99977...6*****************99877766 PP

  == domain 9  score: 19.0 bits;  conditional E-value: 1.7e-06
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                  n +a+++ +l+++deA++ l  a+        ++    +++++n +++++ l++y++Al+ l  +l+i
  EFC37043.1 475 FNARAMAYKHLKKHDEAISDLSSAIKSD-----EN---NVEYYFNRSQCFFDLKNYRQALKDLDTSLEI 535
                 6679********************4333.....33...699**********************999998 PP

  == domain 10  score: 19.3 bits;  conditional E-value: 1.3e-06
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaia 75 
                 n+ ++ + l++y +Al+ l+++lei ++   p+       ++  g +y+++++y+ A++ ++ al+++
  EFC37043.1 511 NRSQCFFDLKNYRQALKDLDTSLEIEKSE--PK------LYYLRGLTYYEMKNYKMAIKDFKGALRLK 570
                 78899*********************666..65......699**********************9985 PP

  == domain 11  score: 8.6 bits;  conditional E-value: 0.003
      TPR_12   7 nnlaavlrrlgrydeAlellekaleiarrl 36 
                 ++++++++ l++y+ A e + ka+++++  
  EFC37043.1 594 YHMGLCYCFLEKYEYAVESFSKAVDLISDK 623
                 389**********************99654 PP

  == domain 12  score: 2.2 bits;  conditional E-value: 0.3
      TPR_12  39 pdhpltattlrnLgrlyralgryeeAlelleea 71 
                 +d+ l a + +  + +y+  g  e Ale ++ +
  EFC37043.1 638 DDNMLHAVYHHERAKAYQIIGMNERALEDFTTV 670
                 677788888888888888888888888877665 PP

  == domain 13  score: 4.4 bits;  conditional E-value: 0.062
      TPR_12   9 laavlrrlgrydeAlellekaleiarrllGpdhplta 45 
                 +a +  +l+r++eA e +eka  ++     p++p+++
  EFC37043.1 684 RAFAWKALERFEEAAEDFEKAKSLQ-----PNNPNLV 715
                 5555567888888888888887777.....6666655 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.067        50      14      33 ..      62      81 ..      60      81 .. 0.91
   2 ?   -0.5   0.0       2.8   2.1e+03      15      34 .]     165     184 ..     159     184 .. 0.87
   3 ?    4.6   0.0     0.068        51      12      32 ..     200     220 ..     186     222 .. 0.83
   4 !   14.2   0.0   5.9e-05     0.044       3      24 ..     225     246 ..     223     256 .. 0.81
   5 !   11.4   0.0   0.00045      0.34       5      33 ..     261     289 ..     258     290 .. 0.90
   6 !   20.2   0.2   7.1e-07   0.00053       5      34 .]     295     324 ..     295     324 .. 0.96
   7 ?   -1.8   0.0       7.4   5.5e+03      16      34 .]     340     358 ..     335     358 .. 0.85
   8 !   16.6   0.1   9.8e-06    0.0073       1      33 [.     359     391 ..     359     392 .. 0.95
   9 ?    1.4   0.0      0.73   5.5e+02       4      24 ..     429     449 ..     427     466 .. 0.79
  10 ?    5.6   0.0     0.031        23      11      33 ..     470     492 ..     461     493 .. 0.91
  11 !   11.1   0.1   0.00057      0.42       5      33 ..     498     526 ..     497     527 .. 0.95
  12 !   11.9   0.0   0.00032      0.24       4      34 .]     531     561 ..     529     561 .. 0.93
  13 ?   -1.4   0.0       5.7   4.2e+03      14      33 ..     591     610 ..     582     611 .. 0.80
  14 ?    4.5   0.0     0.074        55       9      34 .]     640     665 ..     636     665 .. 0.86
  15 !   15.2   0.0   2.7e-05      0.02       2      32 ..     667     697 ..     666     699 .. 0.92
  16 ?   -2.0   0.1       8.5   6.4e+03       6      18 ..     705     717 ..     700     718 .. 0.68

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.067
      TPR_17 14 daynnLAelllknGdlmtAr 33
                ++++++++++++  d+++A+
  EFC37043.1 62 KFHFLRGNCYRHTQDYDRAI 81
                689***************96 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 2.8
      TPR_17  15 aynnLAelllknGdlmtArq 34 
                 +y  ++  ++++G+++ A++
  EFC37043.1 165 LYVDRGLSYYEKGEKKLAIE 184
                 7899999******9999975 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.068
      TPR_17  12 nadaynnLAelllknGdlmtA 32 
                  ++ay+ ++++l++ G+l+  
  EFC37043.1 200 LFKAYFHRGNTLRECGELDAS 220
                 579*************99876 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 5.9e-05
      TPR_17   3 lkaleldPnnadaynnLAelll 24 
                 +ka++ldP+na ++nnL+  + 
  EFC37043.1 225 TKAADLDPKNAAVHNNLGLSFF 246
                 79****************8655 PP

  == domain 5  score: 11.4 bits;  conditional E-value: 0.00045
      TPR_17   5 aleldPnnadaynnLAelllknGdlmtAr 33 
                 ++e+dP+    +nn++ +++k++ +++A+
  EFC37043.1 261 SIENDPTKGIYHNNRGLAYYKLKAFEKAI 289
                 8*******************999888887 PP

  == domain 6  score: 20.2 bits;  conditional E-value: 7.1e-07
      TPR_17   5 aleldPnnadaynnLAelllknGdlmtArq 34 
                 al ldP++ + y+n++++ll  +++++A+q
  EFC37043.1 295 ALNLDPDDGNIYFNRGNTLLAMKRYEEALQ 324
                 7899************************97 PP

  == domain 7  score: -1.8 bits;  conditional E-value: 7.4
      TPR_17  16 ynnLAelllknGdlmtArq 34 
                 ++ ++ ++ + +d  +A+q
  EFC37043.1 340 FHCKGIAYQEMNDIPQAIQ 358
                 688999*******999987 PP

  == domain 8  score: 16.6 bits;  conditional E-value: 9.8e-06
      TPR_17   1 lylkaleldPnnadaynnLAelllknGdlmtAr 33 
                 +++kale++ +++ +++ L+  ++ n++l +A+
  EFC37043.1 359 MFKKALEINEKSVQSLYHLGLMYHINNQLFEAK 391
                 599**************************9997 PP

  == domain 9  score: 1.4 bits;  conditional E-value: 0.73
      TPR_17   4 kaleldPnnadaynnLAelll 24 
                  a+++ P++++ ++ +++++l
  EFC37043.1 429 AAIRIVPDSPNNFFHRGKCFL 449
                 699999***********9987 PP

  == domain 10  score: 5.6 bits;  conditional E-value: 0.031
      TPR_17  11 nnadaynnLAelllknGdlmtAr 33 
                 +++ ++n +A ++++++++++A+
  EFC37043.1 470 DDPQVFNARAMAYKHLKKHDEAI 492
                 6899*****************97 PP

  == domain 11  score: 11.1 bits;  conditional E-value: 0.00057
      TPR_17   5 aleldPnnadaynnLAelllknGdlmtAr 33 
                 a++ d nn++ y+n+ +++  ++++++A+
  EFC37043.1 498 AIKSDENNVEYYFNRSQCFFDLKNYRQAL 526
                 8999***********************97 PP

  == domain 12  score: 11.9 bits;  conditional E-value: 0.00032
      TPR_17   4 kaleldPnnadaynnLAelllknGdlmtArq 34 
                  +le++++ +++y++++ ++++ +++++A++
  EFC37043.1 531 TSLEIEKSEPKLYYLRGLTYYEMKNYKMAIK 561
                 689**************************85 PP

  == domain 13  score: -1.4 bits;  conditional E-value: 5.7
      TPR_17  14 daynnLAelllknGdlmtAr 33 
                 d ++ ++ +++ + +++ A+
  EFC37043.1 591 DCFYHMGLCYCFLEKYEYAV 610
                 678999*****999998775 PP

  == domain 14  score: 4.5 bits;  conditional E-value: 0.074
      TPR_17   9 dPnnadaynnLAelllknGdlmtArq 34 
                 +  +a+ ++++A+++  +G  ++A++
  EFC37043.1 640 NMLHAVYHHERAKAYQIIGMNERALE 665
                 5668999***************9975 PP

  == domain 15  score: 15.2 bits;  conditional E-value: 2.7e-05
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlmtA 32 
                 ++ ++++ P+na ay+ +A +++ + ++++A
  EFC37043.1 667 FTTVIKYQPDNAHAYFRRAFAWKALERFEEA 697
                 6789*********************999988 PP

  == domain 16  score: -2.0 bits;  conditional E-value: 8.5
      TPR_17   6 leldPnnadaynn 18 
                   l Pnn+++  n
  EFC37043.1 705 KSLQPNNPNLVVN 717
                 5678999987666 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       7.5   5.6e+03       8      52 ..      74      84 ..      66     123 .. 0.53
   2 ?    1.1   0.0       0.6   4.5e+02      31      52 ..     165     186 ..     163     199 .. 0.83
   3 ?    5.5   0.0     0.025        19      33      65 ..     205     237 ..     201     239 .. 0.88
   4 !   16.1   0.0   1.2e-05     0.009      34      64 ..     274     304 ..     271     307 .. 0.93
   5 !    9.1   0.0    0.0019       1.4      22      57 ..     296     331 ..     294     338 .. 0.89
   6 ?    3.2   0.0      0.13        97      36      61 ..     344     369 ..     343     375 .. 0.88
   7 !   11.7   0.0    0.0003      0.23      27      63 ..     402     438 ..     397     441 .. 0.91
   8 !   13.5   0.0     8e-05     0.059      23      71 ..     432     480 ..     429     481 .. 0.88
   9 ?    2.7   0.0      0.19   1.4e+02      28      61 ..     471     504 ..     470     514 .. 0.85
  10 !   18.9   0.0   1.7e-06    0.0013       9      58 ..     520     569 ..     514     577 .. 0.90
  11 ?    0.0   0.0       1.3   9.8e+02      36      63 ..     597     624 ..     593     631 .. 0.84
  12 !   20.2   0.0   6.5e-07   0.00049      11      63 ..     660     712 ..     653     715 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 7.5
       TPR_9  8 eedweralavverllllaPddpeerrdRGlllaqlGclsaAladL 52
                 +d++ra+                                   d 
  EFC37043.1 74 TQDYDRAI----------------------------------LDY 84
                44444443..................................222 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.6
       TPR_9  31 errdRGlllaqlGclsaAladL 52 
                 ++ dRGl +++ G  + A++  
  EFC37043.1 165 LYVDRGLSYYEKGEKKLAIENY 186
                 688**********999998865 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.025
       TPR_9  33 rdRGlllaqlGclsaAladLeaylalapdapda 65 
                 + RG  l + G l a ++dL  +++l+p+++++
  EFC37043.1 205 FHRGNTLRECGELDASIEDLTKAADLDPKNAAV 237
                 6689999999******************98776 PP

  == domain 4  score: 16.1 bits;  conditional E-value: 1.2e-05
       TPR_9  34 dRGlllaqlGclsaAladLeaylalapdapd 64 
                  RGl++++l ++++A++d+  +l l+pd+  
  EFC37043.1 274 NRGLAYYKLKAFEKAIEDFSCALNLDPDDGN 304
                 6***************************976 PP

  == domain 5  score: 9.1 bits;  conditional E-value: 0.0019
       TPR_9  22 lllaPddpeerrdRGlllaqlGclsaAladLeayla 57 
                 l l+Pdd   ++ RG  l  + ++++Al+d++ ++ 
  EFC37043.1 296 LNLDPDDGNIYFNRGNTLLAMKRYEEALQDFNLAIN 331
                 779****************************98875 PP

  == domain 6  score: 3.2 bits;  conditional E-value: 0.13
       TPR_9  36 GlllaqlGclsaAladLeaylalapd 61 
                 G+++++++++ +A++ +  +l+++++
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALEINEK 369
                 99******************998875 PP

  == domain 7  score: 11.7 bits;  conditional E-value: 0.0003
       TPR_9  27 ddpeerrdRGlllaqlGclsaAladLeaylalapdap 63 
                 +d++ +  RGl+++ l  ++ A++d+ a++++ pd p
  EFC37043.1 402 HDHRIYESRGLVYMDLLYYELAIQDFSAAIRIVPDSP 438
                 67777888*************************9987 PP

  == domain 8  score: 13.5 bits;  conditional E-value: 8e-05
       TPR_9  23 llaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaeairaq 71 
                  + Pd+p   + RG +   l+++ +A++d++++  +  d+p++  +ra+
  EFC37043.1 432 RIVPDSPNNFFHRGKCFLWLERYTEAVEDFNTAFKQHCDDPQVFNARAM 480
                 678*****************************99776688888888876 PP

  == domain 9  score: 2.7 bits;  conditional E-value: 0.19
       TPR_9  28 dpeerrdRGlllaqlGclsaAladLeaylalapd 61 
                 dp+    R++++ +l    +A+ dL  ++  +++
  EFC37043.1 471 DPQVFNARAMAYKHLKKHDEAISDLSSAIKSDEN 504
                 6666778*******************99987765 PP

  == domain 10  score: 18.9 bits;  conditional E-value: 1.7e-06
       TPR_9   9 edweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylal 58 
                 +++ +al+ ++  l +   +p +++ RGl ++++ +++ A++d+  +l+l
  EFC37043.1 520 KNYRQALKDLDTSLEIEKSEPKLYYLRGLTYYEMKNYKMAIKDFKGALRL 569
                 57889***************************************988854 PP

  == domain 11  score: 0.0 bits;  conditional E-value: 1.3
       TPR_9  36 GlllaqlGclsaAladLeaylalapdap 63 
                 Gl++  l+ ++ A++ +  +++l  d +
  EFC37043.1 597 GLCYCFLEKYEYAVESFSKAVDLISDKE 624
                 999999************9998866655 PP

  == domain 12  score: 20.2 bits;  conditional E-value: 6.5e-07
       TPR_9  11 weralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdap 63 
                 +eral+    ++  +Pd ++ ++ R+++   l+++++A++d+e + +l+p++p
  EFC37043.1 660 NERALEDFTTVIKYQPDNAHAYFRRAFAWKALERFEEAAEDFEKAKSLQPNNP 712
                 799*****************************************999999877 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       3.9   2.9e+03      29      44 ..      65      80 ..      29      82 .. 0.64
   2 ?    7.1   0.0     0.011       7.9       5      53 ..     215     263 ..     211     272 .. 0.84
   3 !   13.5   0.1    0.0001     0.076       6      46 ..     284     324 ..     279     341 .. 0.87
   4 !   11.6   0.0   0.00041       0.3       3      57 ..     349     403 ..     348     409 .. 0.89
   5 !    8.0   0.0    0.0055       4.1       8      66 ..     421     479 ..     420     481 .. 0.93
   6 !   13.3   0.0   0.00012      0.09       6      62 ..     487     543 ..     485     548 .. 0.91
   7 ?   -0.3   0.0       2.2   1.6e+03       2      23 ..     551     573 ..     550     579 .. 0.77
   8 !   10.4   0.0   0.00098      0.73       8      59 ..     661     712 ..     658     719 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 3.9
      TPR_19 29 llLAeallalgqldeA 44
                 l  +++  + ++d A
  EFC37043.1 65 FLRGNCYRHTQDYDRA 80
                4456778888888777 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.011
      TPR_19   5 gdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpe 53 
                 g +++ ++ l++a + dpkna++  +L    ++  ++  Ae+      e
  EFC37043.1 215 GELDASIEDLTKAADLDPKNAAVHNNLGLSFFEKRNFPGAEKRFTLSIE 263
                 788999999*****************99999999999988887665555 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 0.0001
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqldeAea 46 
                  ++ A++ ++ al  dp+++++  +  + lla+++++eA +
  EFC37043.1 284 AFEKAIEDFSCALNLDPDDGNIYFNRGNTLLAMKRYEEALQ 324
                 578899999999999************************87 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 0.00041
      TPR_19   3 aegdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpd 57 
                 +++d  +A++++++al+ + k+   ++ L   +  ++ql eA++   +++e  +d
  EFC37043.1 349 EMNDIPQAIQMFKKALEINEKSVQSLYHLGLMYHINNQLFEAKKQFTKALELVHD 403
                 688999***********************99999999999999998888887666 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0055
      TPR_19   8 aeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddaryasLlA 66 
                 + A++ +++a+   p++++      ++ l l +++eA +  +++ ++  dd+++ +++A
  EFC37043.1 421 ELAIQDFSAAIRIVPDSPNNFFHRGKCFLWLERYTEAVEDFNTAFKQHCDDPQVFNARA 479
                 669999***********************************************998877 PP

  == domain 6  score: 13.3 bits;  conditional E-value: 0.00012
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddarya 62 
                 +++eA++ l++a++ d +n e   +  ++ + l+++ +A + Ld+ +e ++ ++ + 
  EFC37043.1 487 KHDEAISDLSSAIKSDENNVEYYFNRSQCFFDLKNYRQALKDLDTSLEIEKSEPKLY 543
                 79******************************************9999988876555 PP

  == domain 7  score: -0.3 bits;  conditional E-value: 2.2
      TPR_19   2 laegdyaeAlalleqalqe.dpk 23 
                 +++++y  A++ ++ al   +p+
  EFC37043.1 551 YEMKNYKMAIKDFKGALRLkNPQ 573
                 68999***********9763554 PP

  == domain 8  score: 10.4 bits;  conditional E-value: 0.00098
      TPR_19   8 aeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpdda 59 
                 ++Al+ ++ ++++ p+na a  + A a  al +++eA +  +++   +p+++
  EFC37043.1 661 ERALEDFTTVIKYQPDNAHAYFRRAFAWKALERFEEAAEDFEKAKSLQPNNP 712
                 689999*******************************987777777777655 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.0     0.017        12       4      25 ..      65      86 ..      64      91 .. 0.80
   2 ?    4.8   0.1     0.071        53       6      27 ..     169     190 ..     165     191 .. 0.89
   3 ?    1.1   0.0         1   7.6e+02       2      32 ..     203     233 ..     202     234 .. 0.89
   4 ?    4.5   0.0     0.089        66       6      23 ..     275     292 ..     274     301 .. 0.86
   5 ?    4.3   0.1     0.096        72       3      28 ..     306     331 ..     304     333 .. 0.84
   6 ?    6.5   0.0      0.02        15       7      28 ..     344     365 ..     343     370 .. 0.90
   7 ?    1.8   0.1      0.64   4.8e+02       1      28 [.     372     399 ..     372     400 .. 0.77
   8 ?    3.1   0.0      0.23   1.8e+02       3      26 ..     441     464 ..     440     468 .. 0.85
   9 ?    4.8   0.0     0.068        51       6      28 ..     478     500 ..     477     504 .. 0.89
  10 ?    3.7   0.0      0.15   1.1e+02       3      23 ..     509     529 ..     507     533 .. 0.88
  11 ?    5.2   0.2     0.053        40       3      24 ..     543     564 ..     542     572 .. 0.88
  12 ?    7.1   0.0     0.013       9.5       1      28 [.     591     618 ..     591     619 .. 0.90
  13 ?    4.6   0.0      0.08        60      13      33 .]     657     677 ..     647     677 .. 0.80
  14 !    8.2   0.2    0.0056       4.2       2      32 ..     680     710 ..     679     711 .. 0.93

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.017
                HHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6  4 yklalsyrklgdtdkAlealer 25
                ++++ +yr ++d+d+A+  +  
  EFC37043.1 65 FLRGNCYRHTQDYDRAILDYTI 86
                789******66*****976665 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.071
                 HHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAlealerli 27 
                 ++lsy++ g++  A+e + + i
  EFC37043.1 169 RGLSYYEKGEKKLAIENYGKAI 190
                 79*****99*******998876 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 1
                 HHHHHHHHHHH.HHHHHHHHHHHHHHHHH-TT CS
       TPR_6   2 Alyklalsyrk.lgdtdkAlealerlikeYPd 32 
                 A+++++  +r+ + + d+++e l +  +  P+
  EFC37043.1 203 AYFHRGNTLREcG-ELDASIEDLTKAADLDPK 233
                 89999*9***999.********9999998886 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.089
                 HHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAleal 23 
                 ++l+y+kl+  +kA+e +
  EFC37043.1 275 RGLAYYKLKAFEKAIEDF 292
                 79*****99******976 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.096
                 HHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   3 lyklalsyrklgdtdkAlealerlik 28 
                 +++++  +++++++++Al+ ++  i+
  EFC37043.1 306 YFNRGNTLLAMKRYEEALQDFNLAIN 331
                 68899999999999999999887776 PP

  == domain 6  score: 6.5 bits;  conditional E-value: 0.02
                 HHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   7 alsyrklgdtdkAlealerlik 28 
                 + +y++++d  +A++++++ ++
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALE 365
                 789***************9987 PP

  == domain 7  score: 1.8 bits;  conditional E-value: 0.64
                 HHHHHHHHHHH.HHHHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyr.klgdtdkAlealerlik 28 
                 ++ly+l+l y  +  +  +A++ + + ++
  EFC37043.1 372 QSLYHLGLMYHiNN-QLFEAKKQFTKALE 399
                 5799***9777455.88899998888765 PP

  == domain 8  score: 3.1 bits;  conditional E-value: 0.23
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   3 lyklalsyrklgdtdkAlealerl 26 
                 +++++++++ l ++++A+e ++  
  EFC37043.1 441 FFHRGKCFLWLERYTEAVEDFNTA 464
                 5899******88*******99865 PP

  == domain 9  score: 4.8 bits;  conditional E-value: 0.068
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAlealerlik 28 
                 +a++y+ l+++d+A+  l + ik
  EFC37043.1 478 RAMAYKHLKKHDEAISDLSSAIK 500
                 59*****99******99998887 PP

  == domain 10  score: 3.7 bits;  conditional E-value: 0.15
                 HHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   3 lyklalsyrklgdtdkAleal 23 
                 ++++ ++++ l+++++Al+ l
  EFC37043.1 509 YFNRSQCFFDLKNYRQALKDL 529
                 79999*****99*****9866 PP

  == domain 11  score: 5.2 bits;  conditional E-value: 0.053
                 HHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   3 lyklalsyrklgdtdkAleale 24 
                 +y+++l y++++++  A++ ++
  EFC37043.1 543 YYLRGLTYYEMKNYKMAIKDFK 564
                 79*********9**99998775 PP

  == domain 12  score: 7.1 bits;  conditional E-value: 0.013
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrklgdtdkAlealerlik 28 
                 d++y+++l+y  l +++ A+e + + ++
  EFC37043.1 591 DCFYHMGLCYCFLEKYEYAVESFSKAVD 618
                 679*********88*********99875 PP

  == domain 13  score: 4.6 bits;  conditional E-value: 0.08
                 HHHHHHHHHHHHHHHHH-TT- CS
       TPR_6  13 lgdtdkAlealerlikeYPdS 33 
                  g  ++Ale +  +ik  Pd+
  EFC37043.1 657 IGMNERALEDFTTVIKYQPDN 677
                 4899***************95 PP

  == domain 14  score: 8.2 bits;  conditional E-value: 0.0056
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerlikeYPd 32 
                 A++++a + ++l + ++A e +e+  +  P+
  EFC37043.1 680 AYFRRAFAWKALERFEEAAEDFEKAKSLQPN 710
                 9**********88************999998 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0       1.4   1.1e+03       4      33 ..      64      93 ..      61     103 .. 0.71
   2 !   12.5   0.0   0.00029      0.22       2      42 ..     202     242 ..     201     244 .. 0.91
   3 ?   -0.3   0.0       3.6   2.7e+03       8      38 ..     276     306 ..     275     312 .. 0.76
   4 ?    1.9   0.0       0.7   5.2e+02       9      31 ..     304     326 ..     303     331 .. 0.78
   5 !    7.7   0.0    0.0099       7.4       8      42 ..     344     378 ..     338     381 .. 0.85
   6 ?   -0.8   0.0       5.1   3.8e+03       5      30 ..     375     400 ..     371     409 .. 0.69
   7 ?    0.2   0.0       2.5   1.9e+03      10      35 ..     413     438 ..     404     447 .. 0.70
   8 ?   -0.6   0.0       4.4   3.3e+03       8      31 ..     445     468 ..     438     480 .. 0.74
   9 !    8.4   0.0    0.0057       4.3       5      43 ..     476     514 ..     472     515 .. 0.89
  10 ?   -0.7   0.0       4.7   3.5e+03      13      40 ..     518     545 ..     516     548 .. 0.82
  11 ?    3.3   0.0      0.25   1.9e+02       1      32 [.     540     572 ..     540     577 .. 0.87
  12 ?    4.9   0.0     0.076        57       6      43 ..     649     686 ..     645     687 .. 0.90
  13 !    8.7   0.3    0.0045       3.4       2      37 ..     679     714 ..     678     718 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 1.4
      TPR_14  4 llalaeallalGdpdeAiallrralalaPd 33
                + +++  +++ +d+d+Ai  +  a++++ +
  EFC37043.1 64 HFLRGNCYRHTQDYDRAILDYTIAIDTQEE 93
                56788889999*****99888888775544 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 0.00029
      TPR_14   2 eallalaeallalGdpdeAiallrralalaPddaeawllla 42 
                 +a+  ++  l++ G++d++i+ l +a +l+P++a+++  l+
  EFC37043.1 202 KAYFHRGNTLRECGELDASIEDLTKAADLDPKNAAVHNNLG 242
                 688899*****************************997765 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 3.6
      TPR_14   8 aeallalGdpdeAiallrralalaPddaeaw 38 
                 + a++ l  +++Ai+ +  al l+Pdd  ++
  EFC37043.1 276 GLAYYKLKAFEKAIEDFSCALNLDPDDGNIY 306
                 6688888899999988888888888886665 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.7
      TPR_14   9 eallalGdpdeAiallrralala 31 
                  +++++G++  A++ +++al+++
  EFC37043.1 304 NIYFNRGNTLLAMKRYEEALQDF 326
                 56888888888888888888865 PP

  == domain 5  score: 7.7 bits;  conditional E-value: 0.0099
      TPR_14   8 aeallalGdpdeAiallrralalaPddaeawllla 42 
                 + a+ +  d  +Ai+++++al+ + ++ + +++l+
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALEINEKSVQSLYHLG 378
                 7889999999**************99987666665 PP

  == domain 6  score: -0.8 bits;  conditional E-value: 5.1
      TPR_14   5 lalaeallalGdpdeAiallrralal 30 
                 + l+  +  + ++ eA + + +al+l
  EFC37043.1 375 YHLGLMYHINNQLFEAKKQFTKALEL 400
                 66666666777777777777777764 PP

  == domain 7  score: 0.2 bits;  conditional E-value: 2.5
      TPR_14  10 allalGdpdeAiallrralalaPdda 35 
                 +++ l  ++ Ai+ + +a++  Pd++
  EFC37043.1 413 VYMDLLYYELAIQDFSAAIRIVPDSP 438
                 55555556677777888888777776 PP

  == domain 8  score: -0.6 bits;  conditional E-value: 4.4
      TPR_14   8 aeallalGdpdeAiallrralala 31 
                 ++ +l l+++ eA++ ++ a +++
  EFC37043.1 445 GKCFLWLERYTEAVEDFNTAFKQH 468
                 666788999******999999975 PP

  == domain 9  score: 8.4 bits;  conditional E-value: 0.0057
      TPR_14   5 lalaeallalGdpdeAiallrralalaPddaeawlllaq 43 
                  a+a a+ +l ++deAi  l  a++ + ++ e+++   q
  EFC37043.1 476 NARAMAYKHLKKHDEAISDLSSAIKSDENNVEYYFNRSQ 514
                 5899***************************99987766 PP

  == domain 10  score: -0.7 bits;  conditional E-value: 4.7
      TPR_14  13 alGdpdeAiallrralalaPddaeawll 40 
                  l ++++A++ l+  l+   +++ +++l
  EFC37043.1 518 DLKNYRQALKDLDTSLEIEKSEPKLYYL 545
                 6789999999999999999998887765 PP

  == domain 11  score: 3.3 bits;  conditional E-value: 0.25
      TPR_14   1 peallalaeallalGdpdeAiallrrala.laP 32 
                 p+++++++  +++  +++ Ai+ ++ al+ ++P
  EFC37043.1 540 PKLYYLRGLTYYEMKNYKMAIKDFKGALRlKNP 572
                 6799*********************99994466 PP

  == domain 12  score: 4.9 bits;  conditional E-value: 0.076
      TPR_14   6 alaeallalGdpdeAiallrralalaPddaeawlllaq 43 
                 ++a+a+   G  ++A++ +  +++ +Pd+a a+++ a+
  EFC37043.1 649 ERAKAYQIIGMNERALEDFTTVIKYQPDNAHAYFRRAF 686
                 68999999999*********************999886 PP

  == domain 13  score: 8.7 bits;  conditional E-value: 0.0045
      TPR_14   2 eallalaeallalGdpdeAiallrralalaPddaea 37 
                  a+ ++a a  al++++eA++ +++a +l+P+++ +
  EFC37043.1 679 HAYFRRAFAWKALERFEEAAEDFEKAKSLQPNNPNL 714
                 5899999************************99865 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.1     0.011       8.5      26      76 ..      64     114 ..      28     119 .. 0.77
   2 ?    0.2   0.1       1.2   9.2e+02      29      49 ..     166     189 ..     148     206 .. 0.73
   3 !   12.7   0.2   0.00015      0.11      30      77 ..     276     324 ..     254     329 .. 0.91
   4 !    8.5   0.1    0.0031       2.3      21      67 ..     335     382 ..     326     397 .. 0.81
   5 ?    5.7   0.0     0.023        17       3      51 ..     351     400 ..     349     415 .. 0.73
   6 !   14.1   0.1   5.6e-05     0.042      18      79 ..     433     495 ..     412     498 .. 0.87
   7 !   22.2   1.4   1.6e-07   0.00012      18      77 ..     498     561 ..     493     566 .. 0.86
   8 !    7.7   0.1    0.0056       4.2      56      81 ..     590     615 ..     576     616 .. 0.89
   9 ?   -2.4   0.0       8.1     6e+03      25      49 ..     677     704 ..     655     713 .. 0.54

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.011
                 HHHHHHHHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHHHHHH.HTT-HHHHH CS
      ANAPC3  26 ayllAlclylngqykrAyellrkaklnskslgcrylfAqcll.kLkkyeeAi 76 
                  +l + c+ ++++y+rA+  +  a ++ + +++ yl+   ++  ++k+++ i
  EFC37043.1  64 HFLRGNCYRHTQDYDRAILDYTIA-IDTQEEAAFYLARGKCFrTIGKINKSI 114
                 466799***********9888887.777888888888755553557777655 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 1.2
                 H...HHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  29 l...AlclylngqykrAyellrka 49 
                 +   +l++y+ g+ k A+e + ka
  EFC37043.1 166 YvdrGLSYYEKGEKKLAIENYGKA 189
                 1455899**********9988887 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 0.00015
                 HHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHH CS
      ANAPC3  30 AlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAia 77 
                 +l++y+++ +++A+e ++ a +l++ + ++ +  + +ll++k+yeeA++
  EFC37043.1 276 GLAYYKLKAFEKAIEDFSCAlNLDPDDGNIYFNRGNTLLAMKRYEEALQ 324
                 799************************9*******************96 PP

  == domain 4  score: 8.5 bits;  conditional E-value: 0.0031
                 --HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHH CS
      ANAPC3  21 espedayllAlclylngqykrAyellrka.klnskslgcrylfAqcll 67 
                  +++  + ++ ++ ++++  +A++ ++ka ++n+ks +++y ++  + 
  EFC37043.1 335 TDENYFHCKGIAYQEMNDIPQAIQMFKKAlEINEKSVQSLYHLGLMYH 382
                 4556666678899****************************9987665 PP

  == domain 5  score: 5.7 bits;  conditional E-value: 0.023
                 T-HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SH CS
      ANAPC3   3 nnyknAiflaerllaaetespedayllAlclylngqykrAyellrka.kl 51 
                 n++  Ai ++ ++l+ + +s +++y l+l +  n+q  +A + + ka +l
  EFC37043.1 351 NDIPQAIQMFKKALEINEKSVQSLYHLGLMYHINNQLFEAKKQFTKAlEL 400
                 66677888888888888888888888888888888877777777776444 PP

  == domain 6  score: 14.1 bits;  conditional E-value: 5.6e-05
                 HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH CS
      ANAPC3  18 aetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaL 79 
                   ++sp++ +  ++c++ +++y++A e +++a k+ + ++++    A ++  Lkk++eAi+ L
  EFC37043.1 433 IVPDSPNNFFHRGKCFLWLERYTEAVEDFNTAfKQHCDDPQVFNARAMAYKHLKKHDEAISDL 495
                 458999999999***********************************************9865 PP

  == domain 7  score: 22.2 bits;  conditional E-value: 1.6e-07
                 HHH--HHHHHHH...HHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHH CS
      ANAPC3  18 aetespedayll...AlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAia 77 
                 a + +++++ ++   ++c++ +++y +A++ l+++ +++++ ++  yl + +++++k+y+ Ai+
  EFC37043.1 498 AIKSDENNVEYYfnrSQCFFDLKNYRQALKDLDTSlEIEKSEPKLYYLRGLTYYEMKNYKMAIK 561
                 455566665555578********************99999999*****************9997 PP

  == domain 8  score: 7.7 bits;  conditional E-value: 0.0056
                 HHHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3  56 lgcrylfAqcllkLkkyeeAiaaLek 81 
                 + c y ++ c+  L+kye A+  ++k
  EFC37043.1 590 HDCFYHMGLCYCFLEKYEYAVESFSK 615
                 57****************99998876 PP

  == domain 9  score: -2.4 bits;  conditional E-value: 8.1
                 HHHHH...HHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  25 dayll...AlclylngqykrAyellrka 49 
                 +a+++   A +   ++++++A e ++ka
  EFC37043.1 677 NAHAYfrrAFAWKALERFEEAAEDFEKA 704
                 4444333344444444455555544444 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.2    0.0058       4.3       6      29 ..      68      89 ..      64      94 .. 0.83
   2 ?   -1.1   0.0       3.4   2.5e+03       9      28 ..     173     190 ..     166     197 .. 0.75
   3 ?    5.9   0.1      0.02        15       1      34 [.     203     234 ..     203     236 .. 0.89
   4 ?    3.5   0.0      0.11        84       2      33 ..     238     267 ..     237     268 .. 0.90
   5 ?    0.4   0.0       1.1   8.3e+02       3      28 ..     273     298 ..     272     306 .. 0.75
   6 ?    2.2   0.0      0.31   2.3e+02       7      26 ..     304     323 ..     303     337 .. 0.62
   7 !    9.0   0.0    0.0021       1.6       6      29 ..     344     367 ..     343     381 .. 0.89
   8 ?    0.3   0.0       1.2   9.3e+02       3      35 ..     476     506 ..     474     507 .. 0.80
   9 ?    4.1   0.0     0.077        57       3      33 ..     510     540 ..     509     543 .. 0.87
  10 ?    4.4   0.0     0.062        46       3      33 ..     544     574 ..     542     577 .. 0.83
  11 ?    1.1   0.0      0.69   5.2e+02       2      27 ..     593     616 ..     592     626 .. 0.80
  12 ?   -1.0   0.0       3.1   2.3e+03       6      34 ..     651     677 ..     647     678 .. 0.76
  13 ?    4.9   0.0     0.041        31       8      34 ..     687     711 ..     680     713 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0058
       TPR_7  6 arlysrlGdyeeAielyeqsLalt 29
                +++y+  +dy++Ai  y+   a++
  EFC37043.1 68 GNCYRHTQDYDRAILDYTI--AID 89
                99************99987..655 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 3.4
       TPR_7   9 ysrlGdyeeAielyeqsLal 28 
                 y + G+ + Aie y +  a+
  EFC37043.1 173 YYEKGEKKLAIENYGK--AI 190
                 6677888999999998..44 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.02
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLaltkdped 34 
                 a++  +++ +++G+ +  ie +++  a + dp +
  EFC37043.1 203 AYFHRGNTLRECGELDASIEDLTK--AADLDPKN 234
                 67888*******************..99998876 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.11
       TPR_7   2 LlnLarlysrlGdyeeAielyeqsLaltkdpe 33 
                 ++nL+  +++ +++  A++ ++    +++dp+
  EFC37043.1 238 HNNLGLSFFEKRNFPGAEKRFTL--SIENDPT 267
                 79********************9..8888875 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 1.1
       TPR_7   3 lnLarlysrlGdyeeAielyeqsLal 28 
                 +n + +y +l  +e+Aie +  +L l
  EFC37043.1 273 NNRGLAYYKLKAFEKAIEDFSCALNL 298
                 788999999999*****977664444 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.31
       TPR_7   7 rlysrlGdyeeAielyeqsL 26 
                 ++y+++G++  A + ye++L
  EFC37043.1 304 NIYFNRGNTLLAMKRYEEAL 323
                 56666666656666666544 PP

  == domain 7  score: 9.0 bits;  conditional E-value: 0.0021
       TPR_7   6 arlysrlGdyeeAielyeqsLalt 29 
                 + +y++++d  +Ai+ ++++L++ 
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALEIN 367
                 679****************88765 PP

  == domain 8  score: 0.3 bits;  conditional E-value: 1.2
       TPR_7   3 lnLarlysrlGdyeeAielyeqsLaltkdpeda 35 
                 ++ a +y  l +++eAi+ +    a+ +d++++
  EFC37043.1 476 NARAMAYKHLKKHDEAISDLSS--AIKSDENNV 506
                 67788999999******98888..877777765 PP

  == domain 9  score: 4.1 bits;  conditional E-value: 0.077
       TPR_7   3 lnLarlysrlGdyeeAielyeqsLaltkdpe 33 
                 +n  +++++l +y++A++ +  sL+++k++ 
  EFC37043.1 510 FNRSQCFFDLKNYRQALKDLDTSLEIEKSEP 540
                 566689999*****************99875 PP

  == domain 10  score: 4.4 bits;  conditional E-value: 0.062
       TPR_7   3 lnLarlysrlGdyeeAielyeqsLaltkdpe 33 
                 +  + +y ++ +y+ Ai+ ++ +L+l + ++
  EFC37043.1 544 YLRGLTYYEMKNYKMAIKDFKGALRLKNPQT 574
                 66688999**************998887665 PP

  == domain 11  score: 1.1 bits;  conditional E-value: 0.69
       TPR_7   2 LlnLarlysrlGdyeeAielyeqsLa 27 
                 ++ ++ +y+ l +ye A+e + +  a
  EFC37043.1 593 FYHMGLCYCFLEKYEYAVESFSK--A 616
                 6789**************99988..4 PP

  == domain 12  score: -1.0 bits;  conditional E-value: 3.1
       TPR_7   6 arlysrlGdyeeAielyeqsLaltkdped 34 
                 a +y+  G  e+A+e ++   ++ ++p++
  EFC37043.1 651 AKAYQIIGMNERALEDFTT--VIKYQPDN 677
                 5666667888999999998..88888875 PP

  == domain 13  score: 4.9 bits;  conditional E-value: 0.041
       TPR_7   8 lysrlGdyeeAielyeqsLaltkdped 34 
                 ++ +l ++eeA+e +e+  a   +p++
  EFC37043.1 687 AWKALERFEEAAEDFEK--AKSLQPNN 711
                 78899************..87777766 PP

>> SHNi-TPR  SHNi-TPR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.0    0.0049       3.6      17      31 ..      44      58 ..      42      59 .. 0.93
   2 ?    2.0   0.2      0.19   1.4e+02      17      30 ..     285     298 ..     284     298 .. 0.94
   3 ?    2.9   0.0     0.099        74      16      28 ..     318     330 ..     314     331 .. 0.85
   4 ?    4.2   0.0      0.04        30      18      33 ..     354     369 ..     354     373 .. 0.90
   5 ?   -3.0   0.0       7.1   5.3e+03      20      30 ..     390     400 ..     389     400 .. 0.78
   6 ?   -1.7   0.0       2.8   2.1e+03      20      29 ..     423     432 ..     420     433 .. 0.79
   7 !    9.2   0.0     0.001      0.78      12      27 ..     449     464 ..     446     466 .. 0.90
   8 ?   -0.2   0.0       0.9   6.7e+02      18      29 ..     489     500 ..     487     500 .. 0.86
   9 !   10.2   0.1   0.00053       0.4      16      30 ..     521     535 ..     520     538 .. 0.95
  10 ?    5.7   0.0     0.014        10      16      32 ..     555     571 ..     552     572 .. 0.90
  11 ?   -0.7   0.1       1.3     1e+03      15      30 ..     604     619 ..     603     619 .. 0.94
  12 !    9.2   0.3     0.001      0.78      15      27 ..     692     704 ..     691     711 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0049
    SHNi-TPR 17 FpqAveDlrkaLeLr 31
                F++A+eDl++a++ r
  EFC37043.1 44 FKEAAEDLTEAINFR 58
                9**********9976 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.19
    SHNi-TPR  17 FpqAveDlrkaLeL 30 
                 F+ A+eD+  aL+L
  EFC37043.1 285 FEKAIEDFSCALNL 298
                 999*********98 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.099
    SHNi-TPR  16 nFpqAveDlrkaL 28 
                 ++++A++D++ a+
  EFC37043.1 318 RYEEALQDFNLAI 330
                 8********8776 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.04
    SHNi-TPR  18 pqAveDlrkaLeLreq 33 
                 pqA++ ++kaLe+ e+
  EFC37043.1 354 PQAIQMFKKALEINEK 369
                 8************887 PP

  == domain 5  score: -3.0 bits;  conditional E-value: 7.1
    SHNi-TPR  20 AveDlrkaLeL 30 
                 A + ++kaLeL
  EFC37043.1 390 AKKQFTKALEL 400
                 5667999*998 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 2.8
    SHNi-TPR  20 AveDlrkaLe 29 
                 A++D+ +a+ 
  EFC37043.1 423 AIQDFSAAIR 432
                 9****99975 PP

  == domain 7  score: 9.2 bits;  conditional E-value: 0.001
    SHNi-TPR  12 lEnenFpqAveDlrka 27 
                 l+ e++++AveD+++a
  EFC37043.1 449 LWLERYTEAVEDFNTA 464
                 889**********998 PP

  == domain 8  score: -0.2 bits;  conditional E-value: 0.9
    SHNi-TPR  18 pqAveDlrkaLe 29 
                 ++A++Dl +a++
  EFC37043.1 489 DEAISDLSSAIK 500
                 79******9975 PP

  == domain 9  score: 10.2 bits;  conditional E-value: 0.00053
    SHNi-TPR  16 nFpqAveDlrkaLeL 30 
                 n+ qA++Dl+++Le+
  EFC37043.1 521 NYRQALKDLDTSLEI 535
                 9*************8 PP

  == domain 10  score: 5.7 bits;  conditional E-value: 0.014
    SHNi-TPR  16 nFpqAveDlrkaLeLre 32 
                 n++ A++D++ aL L++
  EFC37043.1 555 NYKMAIKDFKGALRLKN 571
                 999***********996 PP

  == domain 11  score: -0.7 bits;  conditional E-value: 1.3
    SHNi-TPR  15 enFpqAveDlrkaLeL 30 
                 e+++ Ave + ka++L
  EFC37043.1 604 EKYEYAVESFSKAVDL 619
                 89***********997 PP

  == domain 12  score: 9.2 bits;  conditional E-value: 0.001
    SHNi-TPR  15 enFpqAveDlrka 27 
                 e+F++A+eD++ka
  EFC37043.1 692 ERFEEAAEDFEKA 704
                 9***********9 PP

>> TPR_15  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.097        72     127     176 ..      38      91 ..      15      99 .. 0.78
   2 ?    0.0   0.0      0.53     4e+02     140     174 ..      88     122 ..      72     131 .. 0.86
   3 ?    2.2   0.0      0.12        88     149     184 ..     204     239 ..     166     242 .. 0.84
   4 !    7.2   0.0    0.0035       2.6     155     248 ..     278     371 ..     270     403 .. 0.89
   5 !    6.0   0.0    0.0082       6.1     141     180 ..     467     506 ..     451     510 .. 0.84
   6 ?    2.1   0.0      0.13        93     131     177 ..     524     571 ..     508     581 .. 0.75
   7 ?    3.8   0.1     0.037        27     118     188 ..     646     688 ..     611     718 .. 0.60

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.097
      TPR_15 127 driaellks....leeeeaaeqsaafllaraelyrqegqtdaAlrdyreAlala 176
                 + +++l+k+    l+e  +++  + f ++r++ yr + + d+A+ dy  A++ +
  EFC37043.1  38 KLTKKLFKEaaedLTEAINFRPLPKFHFLRGNCYRHTQDYDRAILDYTIAIDTQ 91 
                 55677777732223466668999************************9998765 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.53
      TPR_15 140 eaaeqsaafllaraelyrqegqtdaAlrdyreAla 174
                  + +++aaf+lar++  r  g+ ++++ d+ ++++
  EFC37043.1  88 IDTQEEAAFYLARGKCFRTIGKINKSIADFDRGID 122
                 567899***********************999876 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.12
      TPR_15 149 llaraelyrqegqtdaAlrdyreAlalapdsselra 184
                 ++ r++  r+ g+ da+++d+ +A +l+p+++++ +
  EFC37043.1 204 YFHRGNTLRECGELDASIEDLTKAADLDPKNAAVHN 239
                 5678889999999999**********9999988765 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0035
      TPR_15 155 lyrqegqtdaAlrdyreAlalapdsselraallWlliDlgrraeLrellkawkara...esdasLwgplaaAlllLgrpkkALeylrkqakenrkdp 248
                 +y +  + ++A++d+ +Al+l+pd+ ++  +   +l+ ++r++e   +l+ ++ +    ++d+++    + A++ +++  +A + ++k ++ n+k++
  EFC37043.1 278 AYYKLKAFEKAIEDFSCALNLDPDDGNIYFNRGNTLLAMKRYEE---ALQDFNLAInkvDTDENYFHCKGIAYQEMNDIPQAIQMFKKALEINEKSV 371
                 5667777899******************9999999999999997...88888766677799***************************999998876 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.0082
      TPR_15 141 aaeqsaafllaraelyrqegqtdaAlrdyreAlalapdss 180
                 +  ++++++ ara +y+   ++d+A+ d+  A++ + ++ 
  EFC37043.1 467 QHCDDPQVFNARAMAYKHLKKHDEAISDLSSAIKSDENNV 506
                 34489****************************9988765 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.13
      TPR_15 131 ellksleeeeaae.qsaafllaraelyrqegqtdaAlrdyreAlalap 177
                 + lk l    + e +++  +++r+  y +  + + A++d++ Al+l+ 
  EFC37043.1 524 QALKDLDTSLEIEkSEPKLYYLRGLTYYEMKNYKMAIKDFKGALRLKN 571
                 55555554333332788899999999999***************9975 PP

  == domain 7  score: 3.8 bits;  conditional E-value: 0.037
      TPR_15 118 ellerakdydriaellksleeeeaaeqsaafllaraelyrqegqtdaAlrdyreAlalapdssel..raallW 188
                 +  e                              ra++y+  g +++Al+d+  +++++pd++ +  r a+ W
  EFC37043.1 646 YHHE------------------------------RAKAYQIIGMNERALEDFTTVIKYQPDNAHAyfRRAFAW 688
                 4444..............................555555555555555555555555555543211333333 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0         8     6e+03      19      31 ..      45      57 ..      44      58 .. 0.81
   2 ?   -2.2   0.1       5.6   4.2e+03      12      34 ..      71      93 ..      68      94 .. 0.74
   3 ?    0.8   0.0      0.67     5e+02       9      28 ..     208     227 ..     206     230 .. 0.88
   4 ?   -0.8   0.0       2.1   1.6e+03       6      23 ..     239     256 ..     235     258 .. 0.91
   5 ?    1.5   0.0       0.4     3e+02       6      24 ..     273     291 ..     273     293 .. 0.91
   6 !    8.0   0.1    0.0036       2.7       7      29 ..     308     330 ..     304     332 .. 0.86
   7 !   12.2   0.0   0.00017      0.13       9      36 ..     344     371 ..     341     373 .. 0.93
   8 ?    4.5   0.0     0.046        34       4      31 ..     373     400 ..     371     402 .. 0.92
   9 ?   -2.1   0.0       5.4     4e+03      16      25 ..     452     461 ..     450     465 .. 0.79
  10 ?    4.4   0.0     0.049        37       6      25 ..     476     495 ..     474     501 .. 0.83
  11 ?    1.8   0.0      0.31   2.3e+02      14      31 ..     518     535 ..     516     538 .. 0.89
  12 ?    3.2   0.0      0.12        88       9      30 ..     547     568 ..     546     570 .. 0.91
  13 ?   -2.4   0.1       6.9   5.1e+03      10      25 ..     640     655 ..     640     666 .. 0.75
  14 ?   -1.7   0.0       3.9   2.9e+03      17      29 ..     674     686 ..     673     687 .. 0.84
  15 ?    3.7   0.3     0.078        58      10      28 ..     686     704 ..     683     708 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 8
      TPR_10 19 deAealleealai 31
                +eA ++l ea++ 
  EFC37043.1 45 KEAAEDLTEAINF 57
                6999999999986 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 5.6
      TPR_10 12 lrqrgrydeAealleealairrr 34
                +r++++yd+A  ++  a++++++
  EFC37043.1 71 YRHTQDYDRAILDYTIAIDTQEE 93
                89999999998877666666665 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.67
      TPR_10   9 analrqrgrydeAealleea 28 
                 +n+lr+ g++d++ ++l +a
  EFC37043.1 208 GNTLRECGELDASIEDLTKA 227
                 89***********9999887 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 2.1
      TPR_10   6 nNLanalrqrgrydeAea 23 
                 nNL+   ++ +++ +Ae+
  EFC37043.1 239 NNLGLSFFEKRNFPGAEK 256
                 9************99996 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.4
      TPR_10   6 nNLanalrqrgrydeAeal 24 
                 nN + a+++++ +++A ++
  EFC37043.1 273 NNRGLAYYKLKAFEKAIED 291
                 999************9886 PP

  == domain 6  score: 8.0 bits;  conditional E-value: 0.0036
      TPR_10   7 NLanalrqrgrydeAealleeal 29 
                 N +n+l +++ry+eA++++  a+
  EFC37043.1 308 NRGNTLLAMKRYEEALQDFNLAI 330
                 779*************9986665 PP

  == domain 7  score: 12.2 bits;  conditional E-value: 0.00017
      TPR_10   9 analrqrgrydeAealleealairrrll 36 
                 ++a++++++  +A +++++al+i ++ +
  EFC37043.1 344 GIAYQEMNDIPQAIQMFKKALEINEKSV 371
                 89*********************99865 PP

  == domain 8  score: 4.5 bits;  conditional E-value: 0.046
      TPR_10   4 slnNLanalrqrgrydeAealleealai 31 
                 sl +L+ +++  +++ eA + + +al++
  EFC37043.1 373 SLYHLGLMYHINNQLFEAKKQFTKALEL 400
                 7899******************999985 PP

  == domain 9  score: -2.1 bits;  conditional E-value: 5.4
      TPR_10  16 grydeAeall 25 
                  ry+eA++++
  EFC37043.1 452 ERYTEAVEDF 461
                 6999**9987 PP

  == domain 10  score: 4.4 bits;  conditional E-value: 0.049
      TPR_10   6 nNLanalrqrgrydeAeall 25 
                 n  a+a+ +++++deA  +l
  EFC37043.1 476 NARAMAYKHLKKHDEAISDL 495
                 5669************8776 PP

  == domain 11  score: 1.8 bits;  conditional E-value: 0.31
      TPR_10  14 qrgrydeAealleealai 31 
                 ++++y +A+++l+ +l+i
  EFC37043.1 518 DLKNYRQALKDLDTSLEI 535
                 789*************98 PP

  == domain 12  score: 3.2 bits;  conditional E-value: 0.12
      TPR_10   9 analrqrgrydeAealleeala 30 
                 + +++++++y+ A ++++ al+
  EFC37043.1 547 GLTYYEMKNYKMAIKDFKGALR 568
                 789**************99997 PP

  == domain 13  score: -2.4 bits;  conditional E-value: 6.9
      TPR_10  10 nalrqrgrydeAeall 25 
                 n+l++++ +++A a++
  EFC37043.1 640 NMLHAVYHHERAKAYQ 655
                 6888999999998884 PP

  == domain 14  score: -1.7 bits;  conditional E-value: 3.9
      TPR_10  17 rydeAealleeal 29 
                 + d A a++++a 
  EFC37043.1 674 QPDNAHAYFRRAF 686
                 6799*******97 PP

  == domain 15  score: 3.7 bits;  conditional E-value: 0.078
      TPR_10  10 nalrqrgrydeAealleea 28 
                  a  ++ r++eA +++e+a
  EFC37043.1 686 FAWKALERFEEAAEDFEKA 704
                 5778899***********9 PP

>> Paf67  RNA polymerase I-associated factor PAF67
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1      0.08        60     166     211 ..     305     351 ..     302     360 .. 0.83
   2 ?    1.3   0.3      0.18   1.4e+02     152     203 ..     361     410 ..     346     418 .. 0.80
   3 !    7.9   0.0    0.0018       1.4     165     216 ..     439     491 ..     421     501 .. 0.81
   4 ?    1.8   0.1      0.12        92     164     193 ..     540     569 ..     519     585 .. 0.80
   5 !   16.1   0.0   5.7e-06    0.0042     163     206 ..     589     632 ..     562     644 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.08
       Paf67 166 llYyvGfaylmlrrYkDAirtlsqillyisrtkq.yqsrsyqsdqin 211
                 +++  G   l ++rY++A + ++  ++ +   ++ ++ +   ++++n
  EFC37043.1 305 IYFNRGNTLLAMKRYEEALQDFNLAINKVDTDENyFHCKGIAYQEMN 351
                 678889999**************999999988886666766766665 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.18
       Paf67 152 kkallskvpaahvsllYyvGfaylmlrrYkDAirtlsqillyisrtkqyqsr 203
                 kka   ++    v  lY++G+ y +  +  +A + +++ l  ++ ++ y+sr
  EFC37043.1 361 KKA--LEINEKSVQSLYHLGLMYHINNQLFEAKKQFTKALELVHDHRIYESR 410
                 444..35677788999***********************9999888877665 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.0018
       Paf67 165 sllYyvGfaylmlrrYkDAirtlsqillyisrtkq.yqsrsyqsdqinkqadr 216
                 + +++ G ++l l+rY++A++ +++   +     q +++r   +++++k  + 
  EFC37043.1 439 NNFFHRGKCFLWLERYTEAVEDFNTAFKQHCDDPQvFNARAMAYKHLKKHDEA 491
                 5689********************99877766655577888888888887665 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.12
       Paf67 164 vsllYyvGfaylmlrrYkDAirtlsqilly 193
                   l+Y  G+ y  +++Yk Ai+ ++  l  
  EFC37043.1 540 PKLYYLRGLTYYEMKNYKMAIKDFKGALRL 569
                 5689999*****************998865 PP

  == domain 5  score: 16.1 bits;  conditional E-value: 5.7e-06
       Paf67 163 hvsllYyvGfaylmlrrYkDAirtlsqillyisrtkqyqsrsyq 206
                     +Y++G++y  l++Y+ A++ +s+ +  is +++++++++ 
  EFC37043.1 589 GHDCFYHMGLCYCFLEKYEYAVESFSKAVDLISDKENVHTKESS 632
                 55689****************************99998777665 PP

>> DUF3856  Domain of Unknown Function (DUF3856)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0       0.6   4.5e+02      15      38 ..      34      57 ..      27      63 .. 0.88
   2 ?   -1.4   0.0       3.1   2.3e+03     100     127 ..     201     228 ..     168     234 .. 0.76
   3 !    7.1   0.0    0.0071       5.3      75     131 ..     282     334 ..     271     339 .. 0.87
   4 ?   -0.8   0.0       1.9   1.4e+03     106     129 ..     343     366 ..     338     372 .. 0.83
   5 ?    1.8   0.1       0.3   2.2e+02      48      82 ..     465     499 ..     451     521 .. 0.55
   6 !    8.4   0.0    0.0028       2.1      52     126 ..     589     670 ..     548     675 .. 0.76
   7 ?    1.1   0.0      0.52   3.9e+02     102     127 ..     680     705 ..     676     711 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.6
                HHHHHHHHT-HHHHHHHHHHHHHH CS
     DUF3856 15 eaekqleegayeeaaasyrkalev 38
                +a+ +l+++ ++eaa++  +a+++
  EFC37043.1 34 DAKTKLTKKLFKEAAEDLTEAINF 57
                7899**************999986 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 3.1
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHH CS
     DUF3856 100 iaavfsravaleelGrkdealkafrmag 127
                  +a f+r+ +l e G  d +++ + +a+
  EFC37043.1 201 FKAYFHRGNTLRECGELDASIEDLTKAA 228
                 4567888888888888888888777766 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0071
                 HHHHHHHHHHHHHH--TTSTHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
     DUF3856  75 lesadkalryfnrrGeleqdeGklWiaavfsravaleelGrkdealkafrmagemia 131
                 l++ +ka++ f    +l+ d+G+++    f+r+ +l  + r++eal+ f+ a + ++
  EFC37043.1 282 LKAFEKAIEDFSCALNLDPDDGNIY----FNRGNTLLAMKRYEEALQDFNLAINKVD 334
                 7888999999999999999999876....89*******************9987765 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 1.9
                 HHHHHHHTT-HHHHHHHHHHHHHH CS
     DUF3856 106 ravaleelGrkdealkafrmagem 129
                 ++ a++e+    +a+++f++a e+
  EFC37043.1 343 KGIAYQEMNDIPQAIQMFKKALEI 366
                 7889999999999*******9995 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.3
                 --HHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHH CS
     DUF3856  48 fdheGfdalchaglsealaklgrydealesadkal 82 
                 f  +  d  ++ + + a+ +l+++dea++   +a+
  EFC37043.1 465 FKQHCDDPQVFNARAMAYKHLKKHDEAISDLSSAI 499
                 44445555555566666666666666544333332 PP

  == domain 6  score: 8.4 bits;  conditional E-value: 0.0028
                 HHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHH--TTSTHHH..HHH.....HHHH..HHHHHHHHTT-HHHHHHHHHHH CS
     DUF3856  52 GfdalchaglsealaklgrydealesadkalryfnrrGeleqdeGk..lWi.....aavf..sravaleelGrkdealkafrma 126
                 G d + h gl+   + l +y+ a+es  ka+     + +++  e +  l i      av+  +ra+a++ +G ++ al+ f ++
  EFC37043.1 589 GHDCFYHMGLCY--CFLEKYEYAVESFSKAVDLISDKENVHTKESSaaLIIddnmlHAVYhhERAKAYQIIGMNERALEDFTTV 670
                 567778888864..5578999999999999999999999998887522222222226776336999*************99876 PP

  == domain 7  score: 1.1 bits;  conditional E-value: 0.52
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
     DUF3856 102 avfsravaleelGrkdealkafrmag 127
                 a f+ra a + l r +ea + f++a+
  EFC37043.1 680 AYFRRAFAWKALERFEEAAEDFEKAK 705
                 66889999999999999999998886 PP

>> TPR_20  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       9.2   6.9e+03      23      48 ..      29      54 ..      18      57 .. 0.66
   2 ?   -1.2   0.0       3.6   2.7e+03       6      46 ..     219     259 ..     217     269 .. 0.78
   3 !    9.3   0.0    0.0019       1.4       7      46 ..     288     327 ..     283     339 .. 0.84
   4 ?    2.9   0.0      0.19   1.4e+02       7      49 ..     356     398 ..     351     410 .. 0.85
   5 !    7.7   0.1    0.0059       4.4       6      54 ..     456     504 ..     452     514 .. 0.92
   6 ?    6.4   0.1     0.015        11       3      52 ..     487     536 ..     485     544 .. 0.90
   7 ?   -1.9   0.0       5.9   4.4e+03       6      44 ..     524     562 ..     519     569 .. 0.82
   8 ?    2.8   0.0       0.2   1.5e+02      26      55 ..     648     677 ..     640     692 .. 0.84
   9 ?    2.7   0.0      0.22   1.6e+02       7      44 ..     663     700 ..     659     703 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 9.2
      TPR_20 23 darldlAlallaagryeeAleqLlei 48
                + +++ A+  l ++  +eA+e L e 
  EFC37043.1 29 EEKYKDAKTKLTKKLFKEAAEDLTEA 54
                44566666666666677777777665 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 3.6
      TPR_20   6 pelaeleaalaanpddldarldlAlallaagryeeAleqLl 46 
                 +++++l +a+  +p++ + + +l l  +++ +   A +++ 
  EFC37043.1 219 ASIEDLTKAADLDPKNAAVHNNLGLSFFEKRNFPGAEKRFT 259
                 5789999999******9999999988888877777766655 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.0019
      TPR_20   7 elaeleaalaanpddldarldlAlallaagryeeAleqLl 46 
                  ++++  al+ +pdd ++ ++  + lla +ryeeAl+ + 
  EFC37043.1 288 AIEDFSCALNLDPDDGNIYFNRGNTLLAMKRYEEALQDFN 327
                 6788888999**************************9874 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.19
      TPR_20   7 elaeleaalaanpddldarldlAlallaagryeeAleqLleil 49 
                  ++ +++al+ n + ++  + l l ++ +++  eA +q+ + l
  EFC37043.1 356 AIQMFKKALEINEKSVQSLYHLGLMYHINNQLFEAKKQFTKAL 398
                 577889999**********************999988876665 PP

  == domain 5  score: 7.7 bits;  conditional E-value: 0.0059
      TPR_20   6 pelaeleaalaanpddldarldlAlallaagryeeAleqLleilkrdrk 54 
                 + ++++ +a++++ dd +   + A a+ + ++++eA++ L + +k+d +
  EFC37043.1 456 EAVEDFNTAFKQHCDDPQVFNARAMAYKHLKKHDEAISDLSSAIKSDEN 504
                 67899999*************************************9987 PP

  == domain 6  score: 6.4 bits;  conditional E-value: 0.015
      TPR_20   3 adapelaeleaalaanpddldarldlAlallaagryeeAleqLleilkrd 52 
                 ++++ +++l +a++++ ++++  ++ ++  +  ++y++Al+ L + l+ +
  EFC37043.1 487 KHDEAISDLSSAIKSDENNVEYYFNRSQCFFDLKNYRQALKDLDTSLEIE 536
                 678899***********************************997777665 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 5.9
      TPR_20   6 pelaeleaalaanpddldarldlAlallaagryeeAleq 44 
                 + l++l++ l+ ++++ ++ +   l +++ ++y+ A++ 
  EFC37043.1 524 QALKDLDTSLEIEKSEPKLYYLRGLTYYEMKNYKMAIKD 562
                 567888889999999999999999999999999999876 PP

  == domain 8  score: 2.8 bits;  conditional E-value: 0.2
      TPR_20  26 ldlAlallaagryeeAleqLleilkrdrkw 55 
                 ++ A+a+   g +e Ale + +++k + + 
  EFC37043.1 648 HERAKAYQIIGMNERALEDFTTVIKYQPDN 677
                 6889******************99977665 PP

  == domain 9  score: 2.7 bits;  conditional E-value: 0.22
      TPR_20   7 elaeleaalaanpddldarldlAlallaagryeeAleq 44 
                  l+++ + ++ +pd+  a +  A a  a +r eeA+e 
  EFC37043.1 663 ALEDFTTVIKYQPDNAHAYFRRAFAWKALERFEEAAED 700
                 56777888999************************985 PP

>> TPR_MalT  MalT-like TPR region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.0    0.0002      0.15      87     227 ..     303     436 ..     300     452 .. 0.73
   2 ?    0.9   0.0      0.31   2.3e+02     193     312 ..     464     572 ..     450     586 .. 0.60
   3 ?   -2.9   0.0       4.6   3.5e+03      46      78 ..     596     628 ..     594     654 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.0002
    TPR_MalT  87 aeilvaqGrLheAletyeqalqlateqglqqlplvgfllvlladllyEwndLeeAeqhlqeGielleqlepeaaldayvllarialaqGdleeAetlle 185
                 ++i++ +G    A++ ye+alq    +  + + + + ++   +  + E+nd  +A q+ ++++e+ e+      ++++  l   ++  ++l eA++ + 
  EFC37043.1 303 GNIYFNRGNTLLAMKRYEEALQDFNLAINK-VDTDENYFHCKGIAYQEMNDIPQAIQMFKKALEINEKS-----VQSLYHLGLMYHINNQLFEAKKQFT 395
                 578888999999999999999977777666.56777777777999999999999999999999999987.....6666666666666788888888888 PP

    TPR_MalT 186 kaeelaresnfhvdwlanaeevrvrlwlaqgdlaaaerwlea 227
                 ka el++ +++    +  + +  +++ la +d +aa r + +
  EFC37043.1 396 KALELVHDHRIY-ESRGLVYMDLLYYELAIQDFSAAIRIVPD 436
                 888888887762.33334444445666777777766666655 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.31
    TPR_MalT 193 esnfhvdwlanaeevrvrlwlaqgdlaaaerwleaaelpsdddn.hflelelrnlarvllalgrydeAlellerLlkaaeelgrvrslieiliLqalal 290
                 + + h d+++ + +  +++  ++++ +a++++ +a++ +++ ++ +f++       ++   l +y++Al+      +  + l++ +s+ +   L+ l +
  EFC37043.1 464 AFKQHCDDPQVFNARAMAYKHLKKHDEAISDLSSAIKSDENNVEyYFNR------SQCFFDLKNYRQALK------DLDTSLEIEKSEPKLYYLRGLTY 550
                 4445777887777778888888888888888888888777776514433......344444455555533......22333444445555556666666 PP

    TPR_MalT 291 qaqgreeeAlaaLeqALeLAep 312
                 +++ + + A+++ + AL L +p
  EFC37043.1 551 YEMKNYKMAIKDFKGALRLKNP 572
                 6666666666666666666554 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 4.6
    TPR_MalT  46 lGeasllqGdleaAlqalqeaeklarqadslhv 78 
                 +G  +   ++ e A++++++a++l+ + +++h+
  EFC37043.1 596 MGLCYCFLEKYEYAVESFSKAVDLISDKENVHT 628
                 788888888999999999999999888888884 PP

>> BTAD  Bacterial transcriptional activator domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       6.3   4.7e+03       8      33 ..      30      55 ..      26      57 .. 0.60
   2 ?    3.5   0.0      0.12        88      58     102 ..     197     241 ..     170     246 .. 0.90
   3 ?    4.9   0.0     0.043        32      65     122 ..     306     363 ..     263     370 .. 0.87
   4 ?    0.0   0.0       1.4     1e+03      64     105 ..     474     515 ..     423     542 .. 0.74
   5 ?   -1.8   0.1       5.1   3.8e+03      77     121 ..     659     703 ..     640     710 .. 0.51

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 6.3
                HHHHHHHHHHHTT-HHHHHHHHHHHH CS
        BTAD  8 alvaagraalaagdpeeaaelleaAl 33
                +++++++++l +  ++eaae l +A+
  EFC37043.1 30 EKYKDAKTKLTKKLFKEAAEDLTEAI 55
                44556666666666666666666665 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.12
                 HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHHHH CS
        BTAD  58 eelrlealealaeaelrlGraeealaelealvaehPlrErlhrql 102
                 +++ ++a+  + + + ++G+ ++ +++l+++++++P + + h  l
  EFC37043.1 197 QQSLFKAYFHRGNTLRECGELDASIEDLTKAADLDPKNAAVHNNL 241
                 567788999999999*********************998888765 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.043
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHHHHHHHHHHTT-HHHHHHHHHHH CS
        BTAD  65 lealaeaelrlGraeealaelealvaehPlrErlhrqlmrAlarsGrqaeALevYerl 122
                 +  + + +l++ r+eeal++ + ++++ +++E++      A+  +++  +A+++++++
  EFC37043.1 306 YFNRGNTLLAMKRYEEALQDFNLAINKVDTDENYFHCKGIAYQEMNDIPQAIQMFKKA 363
                 556777889999********************99999999*************99987 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHHHHHHH CS
        BTAD  64 alealaeaelrlGraeealaelealvaehPlrErlhrqlmrA 105
                 ++ a+a a  +l +++ea+++l+++++ +  + +++    ++
  EFC37043.1 474 VFNARAMAYKHLKKHDEAISDLSSAIKSDENNVEYYFNRSQC 515
                 455666666778888888888888888776665555544444 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 5.1
                 -HHHHHHHHHHHHHHSTT-HHHHHHHHHHHHHTT-HHHHHHHHHH CS
        BTAD  77 raeealaelealvaehPlrErlhrqlmrAlarsGrqaeALevYer 121
                   e+al++ +  ++ +P +  ++     A  +++r +eA e +e+
  EFC37043.1 659 MNERALEDFTTVIKYQPDNAHAYFRRAFAWKALERFEEAAEDFEK 703
                 444444444444444444444444444444444444444444444 PP

>> NARP1  NMDA receptor-regulated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   4.8       8.9   6.6e+03     440     472 ..      19      52 ..       4      64 .. 0.40
   2 ?    1.2   0.0      0.18   1.3e+02     187     258 ..     157     233 ..     133     260 .. 0.73
   3 ?    7.9   0.0    0.0017       1.3     205     257 ..     316     368 ..     282     373 .. 0.87
   4 ?    9.4   9.9    0.0006      0.45      18     255 ..     452     707 ..     443     712 .. 0.75

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 8.9
                 .....-------------S-SSSTTTT.-S-HHH CS
       NARP1 440 aaekkakkedeeakkededplgekLvk.teepLe 472
                 ++ek  +k+ ee+ k+++  l +kL k   e L 
  EFC37043.1  19 QNEKLMEKKSEEKYKDAKTKLTKKLFKeAAEDLT 52 
                 1111111222222222223333333331233444 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.18
                 -SSHHHHHHHH.HHHHHHHHT-SHHHHHHHHHHH....HH-TT-HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCTTT CS
       NARP1 187 pesallwvlyf.lAqhydklgsrekAleyidkai....ehtptlvelyltKarilkhaGdlkkAaevmeearklDla 258
                  ++++l+ ly      y + g+++ A+e   kai     ++ +l   y  +++ l+  G+l++ +e + +a  lD +
  EFC37043.1 157 ENQSILFQLYVdRGLSYYEKGEKKLAIENYGKAIlmnvTKQQSLFKAYFHRGNTLRECGELDASIEDLTKAADLDPK 233
                 34444555554234556667778888888888873333566889999***************************977 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.0017
                 HT-SHHHHHHHHHHHHH-TT-HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCTT CS
       NARP1 205 lgsrekAleyidkaiehtptlvelyltKarilkhaGdlkkAaevmeearklDl 257
                 ++++e+Al+  + ai++ +t  +++  K+  ++ + d+ +A+++ ++a ++ +
  EFC37043.1 316 MKRYEEALQDFNLAINKVDTDENYFHCKGIAYQEMNDIPQAIQMFKKALEINE 368
                 67899999999999999999999999999999999999999999999877655 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.0006
                 THHHHHHHHHHHHGGG---HHHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-TT-CHHHHHHHHHT...............SSS-HHHHHHHHHHTTTS- CS
       NARP1  18 gkleeAlehLeekekqivDklavketkaelllkLgrkeeAeatyeaLlernpenskYyeglekak.............klskedeeallalydelaeky 103
                 +++ eA+e ++++ kq +D  +v +++a  + +L++++eA + +++ ++   +n +Yy +  ++              ++s e e++  +ly     +y
  EFC37043.1 452 ERYTEAVEDFNTAFKQHCDDPQVFNARAMAYKHLKKHDEAISDLSSAIKSDENNVEYYFNRSQCFfdlknyrqalkdlDTSLEIEKSEPKLYYLRGLTY 550
                 57889*****************************************************99999987666555544433122222222333333333333 PP

                 TT-SHHHHTHH.HH--HHHHHHHHHHHHHHHHHCT-TTH....HHHHGGGGGGSCHHHHHHHHHHHHHTTTTTSSSSTTGG.GSS----SSHHHHHHHH CS
       NARP1 104 prsdaprRlpL.dfleGeeFkelvdkYlrkaLrkgvPsl....fanlksLYedkeKvkileelvegyvkslktsgklsesdnedsekepesallwvlyf 197
                  + +   ++++ df    + k+     l  ++ +g P      f  +   Y   eK +   e +++ v+ ++ ++++++++ ++++  +   +l+++y 
  EFC37043.1 551 YEMKNY-KMAIkDFKGALRLKNPQTGALISSFVQGEPTFghdcFYHMGLCYCFLEKYEYAVESFSKAVDLISDKENVHTKE-SSAALIIDDNMLHAVYH 647
                 333322.33330333334555555556777777777765222266677789999999999999999999888888887766.55677788888999888 PP

                 H..HHHHHHHT-SHHHHHHHHHHHHH-TT-HHHHHHHHHHHHHTT-HHHHHHHHHHHHHC CS
       NARP1 198 l..AqhydklgsrekAleyidkaiehtptlvelyltKarilkhaGdlkkAaevmeearkl 255
                    A+ y+ +g  e+Ale   + i+ +p     y ++a  +k    +++Aae  e+a++l
  EFC37043.1 648 HerAKAYQIIGMNERALEDFTTVIKYQPDNAHAYFRRAFAWKALERFEEAAEDFEKAKSL 707
                 544889999999**********************************************98 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.1     0.012       8.9       8      34 ..     276     302 ..     271     305 .. 0.90
   2 ?    5.5   0.1     0.025        19      14      31 ..     519     536 ..     507     539 .. 0.85
   3 ?    6.5   0.3     0.011       8.6       4      31 ..     543     570 ..     540     579 .. 0.79
   4 ?   -1.2   0.7         3   2.2e+03       1      21 [.     590     610 ..     590     616 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.012
                 HHHHHHHT-HHHHHHHHHHHHHHTTS- CS
  Fis1_TPR_C   8 AlGhyklgeYseArryvdalLeiEPen 34 
                  l++ykl+ +++A +     L+++P+ 
  EFC37043.1 276 GLAYYKLKAFEKAIEDFSCALNLDPDD 302
                 69*************999999999985 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.025
                 HT-HHHHHHHHHHHHHHT CS
  Fis1_TPR_C  14 lgeYseArryvdalLeiE 31 
                 l++Y++A++ +d+ LeiE
  EFC37043.1 519 LKNYRQALKDLDTSLEIE 536
                 8****************9 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.011
                 HHHHHHHHHHHT-HHHHHHHHHHHHHHT CS
  Fis1_TPR_C   4 lYylAlGhyklgeYseArryvdalLeiE 31 
                  Y+  l +y +++Y++A +  +  L++ 
  EFC37043.1 543 YYLRGLTYYEMKNYKMAIKDFKGALRLK 570
                 46669************99888888765 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 3
                 HHHHHHHHHHHHHHT-HHHHH CS
  Fis1_TPR_C   1 reclYylAlGhyklgeYseAr 21 
                 ++c Y+  l +  l +Y+ A 
  EFC37043.1 590 HDCFYHMGLCYCFLEKYEYAV 610
                 69***************9986 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       7.9   5.9e+03      25      36 ..      42      53 ..      25      57 .. 0.52
   2 ?   -1.5   0.0       3.7   2.8e+03      18      32 ..      75      89 ..      73      94 .. 0.89
   3 ?    0.2   0.1       1.1   8.2e+02      16      31 ..     175     190 ..     166     197 .. 0.84
   4 ?    7.4   0.1     0.006       4.4      16      45 ..     308     336 ..     306     351 .. 0.79
   5 ?    1.6   0.0      0.38   2.8e+02      14      33 ..     347     366 ..     340     373 .. 0.78
   6 ?   -1.5   0.0       3.7   2.8e+03      25      39 ..     418     432 ..     389     444 .. 0.70
   7 ?    3.9   0.0     0.078        58      24      43 ..     451     472 ..     451     497 .. 0.78
   8 ?   -1.3   0.0       3.1   2.3e+03       2      18 ..     489     505 ..     488     508 .. 0.80
   9 ?   -0.2   0.1       1.5   1.1e+03      24      42 ..     519     539 ..     519     546 .. 0.78
  10 ?    0.6   0.0      0.81   6.1e+02      25      49 ..     554     578 ..     553     583 .. 0.78
  11 ?    2.7   0.0      0.18   1.4e+02      25      42 ..     604     619 ..     603     633 .. 0.55
  12 ?   -0.2   0.0       1.4   1.1e+03      22      39 ..     689     706 ..     661     721 .. 0.73

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 7.9
         MIT 25 elYkealelLlq 36
                +l+kea e L++
  EFC37043.1 42 KLFKEAAEDLTE 53
                334444444444 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 3.7
         MIT 18 gnyeeAlelYkeale 32
                ++y+ A+  Y+ a++
  EFC37043.1 75 QDYDRAILDYTIAID 89
                89**********998 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 1.1
         MIT  16 nagnyeeAlelYkeal 31 
                 ++g+ + A+e+Y +a+
  EFC37043.1 175 EKGEKKLAIENYGKAI 190
                 6889999*****9997 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.006
         MIT  16 nagnyeeAlelYkealelLlqalke..kneer 45 
                 n+gn   A++ Y+eal+ +++a++   +   +
  EFC37043.1 308 NRGNTLLAMKRYEEALQDFNLAINKvdT---D 336
                 6788889****************95323...3 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.38
         MIT  14 eDnagnyeeAlelYkealel 33 
                 + + ++++ A++++k+ale+
  EFC37043.1 347 YQEMNDIPQAIQMFKKALEI 366
                 55667888999999999985 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 3.7
         MIT  25 elYkealelLlqalk 39 
                  +Y+ a++ ++ a++
  EFC37043.1 418 LYYELAIQDFSAAIR 432
                 467777777777775 PP

  == domain 7  score: 3.9 bits;  conditional E-value: 0.078
         MIT  24 lelYkealelLlqalke..kne 43 
                 le Y+ea+e +++a k+  +++
  EFC37043.1 451 LERYTEAVEDFNTAFKQhcDDP 472
                 689*************544554 PP

  == domain 8  score: -1.3 bits;  conditional E-value: 3.1
         MIT   2 dkAlelvkkAveeDnag 18 
                 d+A++ ++ A+++D+++
  EFC37043.1 489 DEAISDLSSAIKSDENN 505
                 57888889999999875 PP

  == domain 9  score: -0.2 bits;  conditional E-value: 1.5
         MIT  24 lelYkealelLlqalk.e.kn 42 
                 l++Y++al+ L + l  e ++
  EFC37043.1 519 LKNYRQALKDLDTSLEiEkSE 539
                 589********9999877443 PP

  == domain 10  score: 0.6 bits;  conditional E-value: 0.81
         MIT  25 elYkealelLlqalkekneerrell 49 
                 ++Yk a++ ++ al+ kn+++  l+
  EFC37043.1 554 KNYKMAIKDFKGALRLKNPQTGALI 578
                 6899999999999987888776555 PP

  == domain 11  score: 2.7 bits;  conditional E-value: 0.18
         MIT  25 elYkealelLlqalkekn 42 
                 e+Y+ a+e +++a+    
  EFC37043.1 604 EKYEYAVESFSKAVD--L 619
                 555555555555555..2 PP

  == domain 12  score: -0.2 bits;  conditional E-value: 1.4
         MIT  22 eAlelYkealelLlqalk 39 
                 +Ale ++ea e + +a +
  EFC37043.1 689 KALERFEEAAEDFEKAKS 706
                 477777777777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (738 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1013  (0.0565006); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              24  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 4494.76
//
Query:       EFC37044.1  [L=274]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.7e-49  167.4   0.1    3.5e-49  167.1   0.1    1.1  1  Scramblase  Scramblase


Domain annotation for each model (and alignments):
>> Scramblase  Scramblase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  167.1   0.1   1.9e-53   3.5e-49      23     220 ..      77     263 ..      53     264 .. 0.88

  Alignments for each domain:
  == domain 1  score: 167.1 bits;  conditional E-value: 1.9e-53
  Scramblase  23 sllveqqiellevllgfEtaNrYvvkdvagqkvavaaersnalaRqllgthRpfvvkil.DnlgnevltlkRpfkcisclasvlqeaei.eapegttiG 119
                 +  v+q+ie+ e+l+gfEt+N+Y+++  +g  +ava e+s+++aRq++g++Rpf+++i+  ++++e ltl Rp+          +e+++ ++  ++++G
  EFC37044.1  77 KAKVKQRIEPFELLTGFETENKYDINFDNGY-MAVALEESDCCARQYCGPKRPFKMHIAlKQNKQEFLTLDRPYCHF------FHEVNVyDTATNQVLG 168
                 5679*********************877775.67899*********************637899*********8632......23444447789***** PP

  Scramblase 120 evlqkwhlwrrkyellnakreqvlsiegplvkidcvldteFevktadgevvgsisrkwsGllrElftDadtyvvrFpldLdlklkavllgaafliDfdy 218
                  v+ +++l++r+ ++++ ++ ++++i + ++       ++F++++ dge+vg+is+kwsG+++E+ftDad++ ++Fp   ++k+kavllga+fliDf y
  EFC37044.1 169 QVELRFTLFSRELNVFDPEGVKMFEIVSSCC-----ECWTFHIEK-DGERVGKISKKWSGFVKEAFTDADNFGIEFPDRATPKQKAVLLGALFLIDFLY 261
                 *******************977777777655.....679****99.***************************************************** PP

  Scramblase 219 Fe 220
                 Fe
  EFC37044.1 262 FE 263
                 *9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       468  (0.026103); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1626.44
//
Query:       EFC37045.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1344  (0.0749624); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 2983.40
//
Query:       EFC37046.1  [L=326]
Description: hypothetical protein NAEGRDRAFT_59844 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.21   11.9   4.4        7.3    6.9   4.4    2.6  1  Gate         Nucleoside recognition
       0.66   10.2   5.5       0.97    9.7   0.1    2.4  2  DUF5056      Domain of unknown function (DUF5056)
        2.8    8.1   6.8       0.28   11.4   0.5    2.2  2  RDD          RDD family


Domain annotation for each model (and alignments):
>> Gate  Nucleoside recognition
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   4.4    0.0012       7.3      60      97 ..     245     282 ..     146     295 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0012
        Gate  60 vvgtlgtlytsalgellqgfdtpksalafllfvllytp 97 
                 ++gtl ++++++++e+++   +p++ ++fl+f+ll ++
  EFC37046.1 245 IIGTLEMFFGEQTQEIASAGLNPQNLIIFLVFSLLLFV 282
                 456777777***********************999984 PP

>> DUF5056  Domain of unknown function (DUF5056)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   1.5     0.043   2.6e+02      39      87 ..     145     194 ..     135     199 .. 0.60
   2 ?    9.7   0.1   0.00016      0.97      36      91 ..     223     275 ..     208     277 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.043
     DUF5056  39 iwtavcavlavvLFvvldGlelllevlrevftsaiqs..lasidldpkSll 87 
                  wt v++v a+ L  + + + l+ +++  +  s+++s  ++s++++  S++
  EFC37046.1 145 SWTRVVMVFAILL-GIYGCFGLVSQLILVFSYSTFSSveGISVNTSVISII 194
                 4888888777655.4556666666666666556555411445556666654 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00016
     DUF5056  36 lariwtavcavlavvLFvvldGlelllevlrevftsaiqslasidldpkSlliavv 91 
                  +     ++++  vvL+ ++ G   ++++l+ +f +++q+ as++l+p+ l+i  v
  EFC37046.1 223 KNTTIAHLVLLSIVVLYNIIYG---IIGTLEMFFGEQTQEIASAGLNPQNLIIFLV 275
                 4444555566666777777777...6899999********************9865 PP

>> RDD  RDD family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   1.0      0.23   1.4e+03     111     123 ..     156     168 ..     135     215 .. 0.56
   2 ?   11.4   0.5   4.7e-05      0.28      17      88 ..     235     308 ..     222     316 .. 0.67

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.23
         RDD 111 lslvlllllligf 123
                 l  +++ + l++ 
  EFC37046.1 156 LLGIYGCFGLVSQ 168
                 1112222222222 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 4.7e-05
         RDD  17 llliislllallivallnakasaneavagslllllllvlllvllvyqllllsk.kgqTlGklllglkvvd.edg 88 
                 ++++ ++++ ++++  +  +++++e  + +l++  l+++l+  l+ ++l++ + +g+ +G ++ + ++ +  + 
  EFC37046.1 235 IVVLYNIIYGIIGTLEMFFGEQTQEIASAGLNPQNLIIFLVFSLLLFVLMIFAcCGSCIGCQAYRFRIMSkLQD 308
                 3333333333333333356777788888888888888888877777777777779********99999986444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (326 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1246  (0.0694963); expected 358.6 (0.02)
Passed bias filter:                      553  (0.0308439); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.35s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 1829.88
//
Query:       EFC37047.1  [L=2091]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-16   60.3 260.2     0.0014   19.0  12.4   17.6 17  EGF_2     EGF-like domain
    9.2e-05   22.7   0.4    0.00026   21.2   0.4    1.8  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
       0.45   10.3   1.6       0.45   10.3   0.0    1.8  2  DUF4748   Domain of unknown function (DUF4748)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   6.3      0.01        61       7      25 ..      27      45 ..      22      47 .. 0.85
   2 !   17.6   6.4   6.2e-07    0.0037       7      32 .]     189     213 ..     185     213 .. 0.90
   3 !   12.4  12.0   2.6e-05      0.15       5      32 .]     226     252 ..     218     252 .. 0.86
   4 !    5.2   6.3    0.0046        28       5      32 .]     265     290 ..     257     290 .. 0.83
   5 !   10.0   4.2   0.00015       0.9       6      32 .]     304     329 ..     300     329 .. 0.91
   6 !   17.1   9.3   9.1e-07    0.0054       5      32 .]     342     368 ..     334     368 .. 0.87
   7 !    4.2   9.5    0.0094        56      12      32 .]     382     406 ..     373     406 .. 0.69
   8 !   18.7   7.8   2.7e-07    0.0016       6      32 .]     420     445 ..     416     445 .. 0.93
   9 !    7.5  10.9   0.00089       5.3       6      32 .]     459     483 ..     450     483 .. 0.74
  10 ?    2.3   6.2     0.036   2.2e+02       5      32 .]     496     521 ..     488     521 .. 0.83
  11 !   10.0   4.1   0.00014      0.85       5      32 .]     534     560 ..     530     560 .. 0.85
  12 !    5.8   7.6    0.0031        18       6      32 .]     574     598 ..     567     598 .. 0.84
  13 !    5.7   5.7    0.0032        19       7      32 .]     613     638 ..     608     638 .. 0.81
  14 ?   -2.4   6.7       1.1   6.7e+03       6      32 .]     652     676 ..     643     676 .. 0.73
  15 !    9.2   9.4   0.00026       1.6       5      32 .]     689     715 ..     686     715 .. 0.90
  16 !   19.0  12.4   2.3e-07    0.0014       5      32 .]     725     751 ..     720     751 .. 0.87
  17 !   16.0   7.7     2e-06     0.012       5      32 .]     767     793 ..     762     793 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.01
       EGF_2  7 iCgghGtCvnqcGqCdCds 25
                +C+g+G C+ + + C+C++
  EFC37047.1 27 NCNGRGLCNILANTCVCKD 45
                5*******888889***75 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 6.2e-07
       EGF_2   7 iCgghGtCvnqc.GqCdCdsgyqGktC 32 
                  C+  GtC+  + G+C C++gy+G  C
  EFC37047.1 189 VCSSKGTCN--GlGECICSDGYFGGLC 213
                 7********..778**********988 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 2.6e-05
       EGF_2   5 deiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                 ++ C+g GtC+  + + C C++g+ G tC
  EFC37047.1 226 GSVCSGKGTCD--GmNLCNCQNGFLGSTC 252
                 789********..5448************ PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0046
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+  G+C  +   C+C+ gy+G +C
  EFC37047.1 265 TNVCN-LGSCLGPD-LCQCPLGYFGLNC 290
                 56787.599*9777.9*********999 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00015
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + Cg  G+C+++  +C C+s   G+ C
  EFC37047.1 304 NVCGAKGSCIAPD-KCLCQSDILGDVC 329
                 68********999.*********9988 PP

  == domain 6  score: 17.1 bits;  conditional E-value: 9.1e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + Cgg+G+C+ +  +C C++g++G  C
  EFC37047.1 342 TNVCGGNGSCIGLD-KCLCKDGFFGELC 368
                 679********777.9**********99 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.0094
       EGF_2  12 GtC.vnqc.Gq..CdCdsgyqGktC 32 
                 G+C   qc G   C+C+ gy+G +C
  EFC37047.1 382 GVCgLGQCiGTdlCQCPLGYFGLNC 406
                 4454444446445*********999 PP

  == domain 8  score: 18.7 bits;  conditional E-value: 2.7e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + Cgg+G+C+++  qC C+sg +G+ C
  EFC37047.1 420 NVCGGNGSCISPD-QCLCKSGLFGDLC 445
                 78********999.************9 PP

  == domain 9  score: 7.5 bits;  conditional E-value: 0.00089
       EGF_2   6 eiCgghGtCvnqcGq..CdCdsgyqGktC 32 
                   Cg  G+C+   G   C+C +gy+G +C
  EFC37047.1 459 GVCG-FGQCI---GTdlCQCLPGYSGEKC 483
                 4564.78888...4334************ PP

  == domain 10  score: 2.3 bits;  conditional E-value: 0.036
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+  GtC  +  +C+C+ + +G +C
  EFC37047.1 496 TNVCN-LGTCLGPD-VCQCPLNKFGLDC 521
                 56797.5****777.9****99999999 PP

  == domain 11  score: 10.0 bits;  conditional E-value: 0.00014
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + Cgg G+C  +  qC C++   G+ C
  EFC37047.1 534 TNVCGGKGICTGLD-QCLCQPDALGPVC 560
                 578********777.****999988877 PP

  == domain 12  score: 5.8 bits;  conditional E-value: 0.0031
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + Cg  G+Cv +   C+C +gy G  C
  EFC37047.1 574 NVCG-FGQCVGAD-ICSCLPGYGGERC 598
                 6786.9****555.7**********99 PP

  == domain 13  score: 5.7 bits;  conditional E-value: 0.0032
       EGF_2   7 iCgghGtCvnqcGqCdC.dsgyqGktC 32 
                  C+g G C  q G+C C + g  G+ C
  EFC37047.1 613 VCNGLGLCT-QPGKCLCnQVGVLGDLC 638
                 7*******9.678****6667778877 PP

  == domain 14  score: -2.4 bits;  conditional E-value: 1.1
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   Cg  G+C+ ++  C C+   +G  C
  EFC37047.1 652 GVCG-LGSCILPN-ICNCPLDVFGFEC 676
                 4575.48888455.9***988888888 PP

  == domain 15  score: 9.2 bits;  conditional E-value: 0.00026
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+  G+C+ ++  C+C +gy G  C
  EFC37047.1 689 SSVCNSKGSCIGPN-LCQCLNGYGGQFC 715
                 678********888.9**********99 PP

  == domain 16  score: 19.0 bits;  conditional E-value: 2.3e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   +C+++G+C+ ++ qC C+++y+G  C
  EFC37047.1 725 AGACSNQGQCIGPN-QCLCNDNYFGSFC 751
                 568********888.************9 PP

  == domain 17  score: 16.0 bits;  conditional E-value: 2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  e C+g+G+Cv +   C+C +g+ G +C
  EFC37047.1 767 AEVCSGRGQCVGLD-LCQCIDGFDGQNC 793
                 789********666.8***********9 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.4   4.4e-08   0.00026       2      81 ..    1879    1963 ..    1878    1981 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 4.4e-08
                  HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.....SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHC CS
         RGS    2 leslledqpgrslFreFlesefseenlsFwlaveefkka.....keqeelkkkakeIyneylapsspkelnidkklreelekrle 81  
                  ++++++dq+g +lF+ ++ +e ++enl ++++ +   +       +  +l +  +++ + y+a+++++e+ni+ k+r+e e++  
  EFC37047.1 1879 MKRVFDDQDGYNLFEVYCIKEMASENLYLFKELQSSVSLtrsatISVPDLYDLLTNVRKVYIASGATCEVNISAKCRKEFEAFYF 1963
                  67899*****************************9877766666667778888**************************998765 PP

>> DUF4748  Domain of unknown function (DUF4748)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   0.4       2.6   1.5e+04       4      15 ..     147     158 ..     146     160 .. 0.83
   2 ?   10.3   0.0   7.5e-05      0.45       9      47 ..    1829    1866 ..    1824    1871 .. 0.84

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 2.6
     DUF4748   4 siwlgWgslcva 15 
                 s++l Wgs++ a
  EFC37047.1 147 SVTLEWGSGTGA 158
                 78899****987 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 7.5e-05
     DUF4748    9 WgslcvaGigayyfAKrsidadRaakleaerkrmrksne 47  
                  W +l+ +G ++++f+K +i a    kl   +k++++ n+
  EFC37047.1 1829 WYVLVFGGLASFIFTKMNIRALLEGKLNS-KKKQNQGNQ 1866
                  9******************9988888888.777766666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2091 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1135  (0.0633053); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.25u 0.36s 00:00:01.61 Elapsed: 00:00:00.56
# Mc/sec: 11325.02
//
Query:       EFC37048.1  [L=562]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-13   49.9   0.2    1.2e-12   48.8   0.3    1.6  1  Metallophos    Calcineurin-like phosphoesterase
  ------ inclusion threshold ------
      0.065   13.4   0.0       0.28   11.4   0.0    2.0  3  Metallophos_2  Calcineurin-like phosphoesterase superfamily d


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.8   0.3   1.3e-16   1.2e-12       3     111 ..     269     379 ..     267     466 .. 0.69

  Alignments for each domain:
  == domain 1  score: 48.8 bits;  conditional E-value: 1.3e-16
                  EEEEESBTBTTCCTHHHHHHHHHHHH.....HHHTTESEEEEESTSSSSSHHHHHHHHHHHHHHHH..TSEEEEEC-TTSCHHH.HHHHHHHHHHHH. CS
  Metallophos   3 ilvigDlHlalgggqlddllkllddl.....lreekpdlvllaGDlvdrgdlekellellaalvky..pipvylllGNHegfee.ellnkygylgif. 91 
                  i+ igDlH     g+l++l+ l+ +l     ++ ++ + ++++GD+vdrg+  ke++e+l +l k+  p   ++l+GNH+ f +   l +++++ +  
   EFC37048.1 269 IVAIGDLH-----GHLSALKLLMLKLeealgNDLHQKYHLVFLGDYVDRGPKIKETIEYLIQLEKSrkPGTTHFLMGNHD-FAMaMFLGLFDDQVKEg 360
                  899*****.....**********66644444444999*************9999999996666665477788********.55545555555554444 PP

                  HHHHEHHHCEEETSEEEEEE CS
  Metallophos  92 sepwrsdaevfnnlplaslg 111
                    +  +++++f n+ l+  g
   EFC37048.1 361 ESLGSTCKGYFKNYELWK-G 379
                  555556666666666666.2 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.1   9.7e+03     137     150 ..     194     207 ..     177     211 .. 0.64
   2 ?   11.4   0.0   3.1e-05      0.28       3      63 ..     269     346 ..     268     391 .. 0.70
   3 ?   -2.0   0.0      0.39   3.5e+03     114     141 ..     492     519 ..     410     528 .. 0.63

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.1
  Metallophos_2 137 gvlvvnPGsvgepr 150
                       +  PGsv++ +
     EFC37048.1 194 TSSIMSPGSVAPSS 207
                    23556799999875 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 3.1e-05
  Metallophos_2   3 laiiSDlH........snldaleavlealkevgvdaiihaGDl..eeeepe.vleellela......pvlaVrGNnD..e 63 
                    +++i DlH          l++ ea+ ++l +    +++++GD+   + + + ++e l++l+        +   GN+D  +
     EFC37048.1 269 IVAIGDLHghlsalklLMLKLEEALGNDLHQK--YHLVFLGDYvdRGPKIKeTIEYLIQLEksrkpgTTHFLMGNHDfaM 346
                    6799****555444444444444556666666..79******95533333347788888779999999*********541 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.39
  Metallophos_2 114 eaeegsdvvvcGHtHvpevekeggvlvv 141
                     +e+  + +v+GH  v +v+  +++ +v
     EFC37048.1 492 GHEDSTRRIVSGHMQVDRVKVSQKRALV 519
                    2344555777888777777777666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (562 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1007  (0.056166); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.54
# Mc/sec: 3118.69
//
Query:       EFC37049.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.2   11.9  12.6         10    6.4  12.6    2.5  1  Pmp3      Proteolipid membrane potential modulator


Domain annotation for each model (and alignments):
>> Pmp3  Proteolipid membrane potential modulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4  12.6   0.00058        10       8      47 ..      16      93 ..      10      95 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.00058
        Pmp3  8 aiilPPlaValk...........sGcsadllinilLtl...........................lgylPgviHAfyi 47
                 +++PPla++l            + ++ ++li+++L                             + y+P+++HA ++
  EFC37049.1 16 IVLCPPLAILLMrfypkdhyddlKSFNLHILISFVLLTicyfipeidggfrtqlkqfyfylflkgIVYIPAILHASFM 93
                5789*******85666666666555666677776554458888******************999999********775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       491  (0.0273858); expected 358.6 (0.02)
Passed bias filter:                      203  (0.0113224); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 665.41
//
Query:       EFC37050.1  [L=461]
Description: N-acetylglucosaminylaminotransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      8e-05   21.6   2.1    0.00029   19.7   2.1    1.8  1  GNT-I     GNT-I family
  ------ inclusion threshold ------
      0.036   13.1   0.1      0.057   12.5   0.1    1.3  1  AGT       DNA alpha-glucosyltransferase
       0.16   12.2   0.0       0.26   11.4   0.0    1.5  1  ExbD      Biopolymer transport protein ExbD/TolR


Domain annotation for each model (and alignments):
>> GNT-I  GNT-I family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   2.1   4.9e-08   0.00029     127     217 ..     203     296 ..     145     435 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 4.9e-08
       GNT-I 127 livsqdcsn..eevkkevlsygdkvtyikhldlesiave.Pderkltayykiarhyklaldqvfvkkkfsrviileddleiapdffdyfeatas 217
                 l+v+ d+++  + v++ ++    kv+   h+ l+++     d+r+l +   +  hy + l  + +k +++ vi leddle +pdf+ +  + ++
  EFC37050.1 203 LYVTIDGGDfdQVVEELIKVKCVKVKIYFHPILSDLRNLgLDKRNLDTGLVLNSHYVYGLYLLTHKLDYPYVITLEDDLEPTPDFYRFHYSLYH 296
                 56677766421345555555566777666664554443335788899999999********************************998776554 PP

>> AGT  DNA alpha-glucosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   9.5e-06     0.057      93     164 ..     222     293 ..     185     311 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 9.5e-06
                 TSEEEEEE---SHHHHTTBSSHHHHHH.H-SEEEES-TTSHHHHTHHHHHS-SS--SSS-------EEE---- CS
         AGT  93 sirvvvyqhdhsvlslrrnlgleetvr.radvifshsdngdfnkvlmkewypetvslfddieeaptvynfqpp 164
                    v v  + h +ls  rnlgl++       v+ sh   g +  +  k  yp  ++l dd+e +p  y f+  
  EFC37050.1 222 VKCVKVKIYFHPILSDLRNLGLDKRNLdTGLVLNSHYVYGLY-LLTHKLDYPYVITLEDDLEPTPDFYRFHYS 293
                 334455556689**********98655055567788888865.5678899*******************9865 PP

>> ExbD  Biopolymer transport protein ExbD/TolR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   4.4e-05      0.26      16      66 ..      15      75 ..      14     191 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4.4e-05
        ExbD 16 vvflLLifFlvtaklkkpepl.evdlPsssstqkeveekelirisisad.........gsi 66
                v+f+L++ Fl+ +++++p +    +l + ++t+ + +ek+l +i++ +d         g+i
  EFC37050.1 15 VLFILMTTFLYYSVFSTPHKYeTYQLEKRNQTKHNSSEKDLFIINLPKDvnlvpvkpvGQI 75
                79*****************996778899999999************999433333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (461 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       523  (0.0291706); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 2997.50
//
Query:       EFC37051.1  [L=115]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (115 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       191  (0.0106531); expected 358.6 (0.02)
Passed bias filter:                      182  (0.0101512); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.47
# Mc/sec: 738.31
//
Query:       EFC37052.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.081   13.0   0.0       0.17   12.0   0.0    1.6  1  DnaGprimase_HBD  DnaG-primase C-terminal, helicase-binding do


Domain annotation for each model (and alignments):
>> DnaGprimase_HBD  DnaG-primase C-terminal, helicase-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   9.6e-06      0.17      17      62 ..      79     124 ..      75     141 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 9.6e-06
                      HHHHHTTT--GGG-SS-HHHHHHHHTT-TT-HHHHHHHH-TT---- CS
  DnaGprimase_HBD  17 lldsvldyidaslfkykkeefelllqgelddpkLlailldeklkal 62 
                      ++++++ +id +  + +++  + +l+ e+d+p+L ++++d+ +k  
       EFC37052.1  79 IVNKMIGMIDWEDWDGHSAVECDVLSFEIDHPHLYQLVVDDMIKKA 124
                      56788999999999999999999*******************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      615  (0.034302); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 999.06
//
Query:       EFC37053.1  [L=301]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00012   21.9   1.5    0.00065   19.5   0.2    2.4  2  F-box         F-box domain
    0.00018   21.3   0.0    0.00044   20.1   0.0    1.7  1  F-box-like    F-box-like
  ------ inclusion threshold ------
      0.026   14.6   1.3      0.042   13.9   1.3    1.3  1  Gemini_AL1_M  Geminivirus rep protein central domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.2   1.1e-07   0.00065       6      44 ..      12      51 ..      10      54 .. 0.93
   2 ?    0.5   0.1       0.1     6e+02      12      23 ..     109     120 ..     109     121 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.1e-07
                S-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHHHH CS
       F-box  6 LPsevlrhILerLplsd.llalrrVSkgwrilidsdrlwc 44
                ++s+ l+h + +L+ls+ + ++++VSk ++++ +s  +w 
  EFC37053.1 12 MCSDTLMHSFLFLDLSTmIASCSLVSKQFNRVAKSNPIWQ 51
                67899******************************99985 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.1
                 HHHHHTS-HHHH CS
       F-box  12 rhILerLplsdl 23 
                 ++ILe Lp  dl
  EFC37053.1 109 MEILECLPRLDL 120
                 69******9986 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.0   7.3e-08   0.00044      13      46 ..      21      54 ..      14      56 .. 0.81

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 7.3e-08
  F-box-like 13 FsyLpps.dLlrlalVCrrWrrvaldtplLWrrlv 46
                F +L++s  +++++lV+++++rva ++  +W+ l+
  EFC37053.1 21 FLFLDLStMIASCSLVSKQFNRVAKSN-PIWQILY 54
                667898845777************999.9998666 PP

>> Gemini_AL1_M  Geminivirus rep protein central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   1.3     7e-06     0.042      23      79 ..      40      97 ..      26     103 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 7e-06
  Gemini_AL1_M 23 leiikeelPkDyvlkldnlesnadk.ifpeipeefvppfplssftnlpeemqdWvdde 79
                   +++ + +P   +l  + +  n++   ++   eef++ f+lss ++  e+++dW +++
    EFC37053.1 40 FNRVAKSNPIWQILYDKWMFDNMNEfYWTFNHEEFINCFKLSSDQENRENLEDWTEPN 97
                  56677777764444444455555551678899**********************9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       461  (0.0257125); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1968.85
//
Query:       EFC37054.1  [L=2065]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.7e-64  211.5 403.5    3.7e-05   23.4  10.9   26.9 31  Ephrin_rec_like  Putative ephrin-receptor like
    3.9e-09   36.8   4.5    7.2e-09   35.9   4.5    1.5  1  RGS              Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   9.0    0.0011       9.9      11      43 ..      43      73 ..      35      77 .. 0.50
   2 !   13.1   6.7   6.7e-06      0.06       1      36 [.      49      85 ..      49      85 .. 0.90
   3 !   10.2   6.4   5.5e-05      0.49       1      31 [.      65      96 ..      65      98 .. 0.85
   4 !   14.2   8.0   3.1e-06     0.027       1      33 [.      83     114 ..      83     115 .. 0.93
   5 !   16.0  11.8   8.2e-07    0.0073       1      36 [.      99     133 ..      99     135 .. 0.93
   6 !   19.2  15.3   8.6e-08   0.00077       1      48 []     115     161 ..     115     161 .. 0.97
   7 !   20.9   7.6   2.6e-08   0.00023       1      48 []     131     181 ..     131     181 .. 0.89
   8 !   13.8   1.9     4e-06     0.036       7      34 ..     157     187 ..     155     189 .. 0.89
   9 !   15.0   8.1   1.8e-06     0.016       1      35 [.     187     220 ..     187     221 .. 0.90
  10 !   16.4   8.1   6.1e-07    0.0055       1      35 [.     219     252 ..     219     252 .. 0.96
  11 !   18.7  10.1   1.2e-07    0.0011       1      36 [.     251     285 ..     251     285 .. 0.93
  12 !   23.4  10.9   4.1e-09   3.7e-05       1      48 []     283     333 ..     283     333 .. 0.89
  13 !    5.1   4.7    0.0021        19      10      33 ..     332     354 ..     329     355 .. 0.87
  14 !   14.0   9.8   3.5e-06     0.031       1      34 [.     355     387 ..     355     388 .. 0.93
  15 !   15.7  10.3     1e-06    0.0091       1      35 [.     387     420 ..     387     420 .. 0.92
  16 !   19.7  11.8     6e-08   0.00054       1      36 [.     419     453 ..     419     453 .. 0.92
  17 !   11.5  19.6   2.1e-05      0.19       1      48 []     451     496 ..     451     496 .. 0.86
  18 !   15.8  11.1   9.6e-07    0.0086       1      36 [.     483     517 ..     483     518 .. 0.93
  19 !   22.3  16.4     9e-09   8.1e-05       1      48 []     499     545 ..     499     545 .. 0.96
  20 !    9.3   3.9    0.0001      0.91       9      35 ..     543     568 ..     540     568 .. 0.84
  21 !   16.5  10.5   5.8e-07    0.0052       1      35 [.     567     600 ..     567     600 .. 0.92
  22 !   17.4  10.5     3e-07    0.0027       1      35 [.     599     632 ..     599     632 .. 0.93
  23 !   17.9  10.9   2.1e-07    0.0019       1      35 [.     631     664 ..     631     664 .. 0.92
  24 !   13.5  14.7   5.1e-06     0.046       1      44 [.     663     704 ..     663     708 .. 0.84
  25 !    9.6  16.0   8.5e-05      0.76       1      48 []     695     740 ..     695     740 .. 0.90
  26 !   14.9  10.6   1.9e-06     0.017       1      37 [.     711     746 ..     711     748 .. 0.90
  27 !   14.7   8.6   2.1e-06     0.019       1      33 [.     743     774 ..     743     775 .. 0.93
  28 !   19.1  10.0   8.8e-08   0.00079       1      48 []     775     825 ..     775     825 .. 0.89
  29 !   14.0  11.6   3.5e-06     0.032       7      48 .]     821     861 ..     811     861 .. 0.87
  30 !   21.8   6.2   1.3e-08   0.00011       5      36 ..     854     886 ..     851     894 .. 0.85
  31 ?   -1.9   0.0      0.33     3e+03      26      38 ..     967     980 ..     959     982 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0011
  Ephrin_rec_like 11 CipCprgtYqneegqlsClaCPlgtttkkpgat 43
                     C  Cp gtY  ++  +sC+ C +g + +++g+t
       EFC37054.1 43 CLDCPGGTYS-SGMTTSCSDCSAGYY-SEVGST 73
                     6666666664.345556666655433.233433 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 6.7e-06
  Ephrin_rec_like  1 GtysntgletCipCprgtYqn.eegqlsClaCPlgtt 36
                     Gtys++ +  C+ C+ g+Y +  + +++C+ C +gt+
       EFC37054.1 49 GTYSSGMTTSCSDCSAGYYSEvGSTSSDCSICAAGTY 85
                     9********************6667889****99875 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 5.5e-05
  Ephrin_rec_like  1 Gtysn..tgletCipCprgtYqneegqlsClaC 31
                     G+ys   ++++ C+ C  gtY n+ + +sC++C
       EFC37054.1 65 GYYSEvgSTSSDCSICAAGTYSNN-RASSCTNC 96
                     888876688899*********987.6789**** PP

  == domain 4  score: 14.2 bits;  conditional E-value: 3.1e-06
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPl 33 
                      Gtysn+ ++ C+ C  gtY   +g +sC++C +
       EFC37054.1  83 GTYSNNRASSCTNCAGGTYS-AGGASSCTSCSA 114
                      9******************7.599*******86 PP

  == domain 5  score: 16.0 bits;  conditional E-value: 8.2e-07
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtt 36 
                      Gtys +g++ C++C+ g+Y  ++g++sC +C++gt+
       EFC37054.1  99 GTYSAGGASSCTSCSAGYYS-SAGSSSCYQCGAGTY 133
                      9******************6.6899*******9987 PP

  == domain 6  score: 19.2 bits;  conditional E-value: 8.6e-08
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48 
                      G+ys++g++ C  C  gtY  ++g +sC++C +g + +++gats s C
       EFC37054.1 115 GYYSSAGSSSCYQCGAGTYS-TGGASSCTNCAAGYYSSTVGATSSSVC 161
                      9******************6.89**********************999 PP

  == domain 7  score: 20.9 bits;  conditional E-value: 2.6e-08
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqls...ClaCPlgtttkkpgatsesdC 48 
                      Gtys +g++ C+ C  g+Y +++g +s   Cl+C +gt+ +++ a  +s+C
       EFC37054.1 131 GTYSTGGASSCTNCAAGYYSSTVGATSssvCLMCSAGTYSTISVAGGASSC 181
                      9********************776655455**********99999999988 PP

  == domain 8  score: 13.8 bits;  conditional E-value: 4e-06
  Ephrin_rec_like   7 gletCipCprgtYqn...eegqlsClaCPlg 34 
                      +++ C +C+ gtY      +g +sC++C +g
       EFC37054.1 157 SSSVCLMCSAGTYSTisvAGGASSCTSCSAG 187
                      5677*************9**********976 PP

  == domain 9  score: 15.0 bits;  conditional E-value: 1.8e-06
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgt 35 
                      G+ys++g++ C+ C  gtY + ++++sC++C +g 
       EFC37054.1 187 GYYSSAGASSCSQCGAGTYSA-VSSSSCTNCAAGS 220
                      9******************86.6789*****8875 PP

  == domain 10  score: 16.4 bits;  conditional E-value: 6.1e-07
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgt 35 
                      G+ys++g++ C++C+ g Y++++g++sC++C++gt
       EFC37054.1 219 GSYSSAGSSSCTSCSAG-YRSSAGSSSCSQCGAGT 252
                      99***************.9************9875 PP

  == domain 11  score: 18.7 bits;  conditional E-value: 1.2e-07
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtt 36 
                      Gtys +g++ C++C+ g+Y  ++g++sC++C++gt+
       EFC37054.1 251 GTYSAGGASSCTSCSAGYYS-SAGSSSCSQCGAGTY 285
                      9******************6.6899*******9985 PP

  == domain 12  score: 23.4 bits;  conditional E-value: 4.1e-09
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqls...ClaCPlgtttkkpgatsesdC 48 
                      Gtys +g++ C+ C  gtY +++g +s   Cl+C +gt+ +++gats++ C
       EFC37054.1 283 GTYSAGGASSCTNCGAGTYSSTVGGTSssvCLNCVAGTYSTISGATSATVC 333
                      9********************666443344******************999 PP

  == domain 13  score: 5.1 bits;  conditional E-value: 0.0021
  Ephrin_rec_like  10 tCipCprgtYqneegqlsClaCPl 33 
                       C+ C  g++  ++g++sC++C +
       EFC37054.1 332 VCQNCNAGSFS-TGGSSSCTNCAA 354
                      5*********6.89********75 PP

  == domain 14  score: 14.0 bits;  conditional E-value: 3.5e-06
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlg 34 
                      G+ys +g++ C+ C  gtY  ++g++sC +C +g
       EFC37054.1 355 GYYSASGSSSCSQCGAGTYS-TGGSSSCASCAAG 387
                      9******************6.89********865 PP

  == domain 15  score: 15.7 bits;  conditional E-value: 1e-06
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgt 35 
                      G+ys++g++ C++C+ g+Y n  g++sC++C++gt
       EFC37054.1 387 GSYSSAGSSSCTSCSAGYYSNP-GSSSCSQCGAGT 420
                      99*****************876.789*****9875 PP

  == domain 16  score: 19.7 bits;  conditional E-value: 6e-08
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtt 36 
                      Gtys+tg++ C++C+ g+Y n +g++sC++C++gt+
       EFC37054.1 419 GTYSSTGSSSCTSCSAGYYSN-SGSSSCSQCGAGTY 453
                      9******************86.6889******9985 PP

  == domain 17  score: 11.5 bits;  conditional E-value: 2.1e-05
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48 
                      Gtys +g++ C++C+ g+Y  ++g++sC++C++gt+ +  ga+s ++C
       EFC37054.1 451 GTYSTGGSSGCTSCSAGYYS-SAGSSSCSQCGAGTYSTG-GASSCTSC 496
                      9******************6.6899*******9998654.66666666 PP

  == domain 18  score: 15.8 bits;  conditional E-value: 9.6e-07
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtt 36 
                      Gtys +g++ C++C  g+Y  ++g++sC++C++gt+
       EFC37054.1 483 GTYSTGGASSCTSCLAGYYS-SAGSSSCSQCGAGTY 517
                      9******************6.6899*******9986 PP

  == domain 19  score: 22.3 bits;  conditional E-value: 9e-09
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48 
                      G+ys++g++ C+ C  gtY  ++g++sC++C++gt+ ++pgat++  C
       EFC37054.1 499 GYYSSAGSSSCSQCGAGTYS-TGGSSSCTNCGAGTYSSTPGATNAGVC 545
                      9******************6.89*********************8777 PP

  == domain 20  score: 9.3 bits;  conditional E-value: 0.0001
  Ephrin_rec_like   9 etCipCprgtYqneegqlsClaCPlgt 35 
                        C  C+ g+Y  ++g +sC++C +gt
       EFC37054.1 543 GVCLTCSAGYYS-SVGASSCSKCSAGT 568
                      57********96.6899******9875 PP

  == domain 21  score: 16.5 bits;  conditional E-value: 5.8e-07
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgt 35 
                      Gtys++g++ C+ C  g+Y  ++g++sC++C++gt
       EFC37054.1 567 GTYSSSGSSSCTNCAAGYYS-TSGSSSCSQCGAGT 600
                      9******************6.67999*****9875 PP

  == domain 22  score: 17.4 bits;  conditional E-value: 3e-07
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgt 35 
                      Gtys +g++ C++C+ g+Y  ++g++sC++C++gt
       EFC37054.1 599 GTYSTGGSSSCTSCSAGYYS-SAGSSSCSQCGAGT 632
                      9******************6.6899******9875 PP

  == domain 23  score: 17.9 bits;  conditional E-value: 2.1e-07
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgt 35 
                      Gtys+tg++ C++C+ g+Y  ++g++sC++C++gt
       EFC37054.1 631 GTYSSTGSSSCTSCSAGYYS-TSGSSSCSQCGAGT 664
                      9******************6.67999*****9875 PP

  == domain 24  score: 13.5 bits;  conditional E-value: 5.1e-06
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtttkkpgats 44 
                      Gtys +g++ C+ C+ g Y++++g++sC++C++gt+ +  g++s
       EFC37054.1 663 GTYSTGGSSSCTICSAG-YRSSAGSSSCSQCGAGTFSTG-GSSS 704
                      9****************.9*************8877543.4445 PP

  == domain 25  score: 9.6 bits;  conditional E-value: 8.5e-05
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48 
                      Gt+s +g++ C  C  g+Y  ++g+++C++C +g + +++g++s s+C
       EFC37054.1 695 GTFSTGGSSSCANCTAGSYS-SVGSSNCTSCLAGYY-SSTGSSSCSQC 740
                      9******************7.68999*****98755.78999999999 PP

  == domain 26  score: 14.9 bits;  conditional E-value: 1.9e-06
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPlgttt 37 
                      G+ys+ g++ C++C  g+Y +  g++sC++C++gt+ 
       EFC37054.1 711 GSYSSVGSSNCTSCLAGYYSS-TGSSSCSQCGAGTYS 746
                      99*****************86.5889******99985 PP

  == domain 27  score: 14.7 bits;  conditional E-value: 2.1e-06
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneegqlsClaCPl 33 
                      Gtys ++++ C++C  g+Y  ++g +sC++C++
       EFC37054.1 743 GTYSTSASSNCSSCGAGSYS-SAGASSCSQCGA 774
                      9******************7.689*******86 PP

  == domain 28  score: 19.1 bits;  conditional E-value: 8.8e-08
  Ephrin_rec_like   1 GtysntgletCipCprgtYqneeg...qlsClaCPlgtttkkpgatsesdC 48 
                      Gtys +g++ C+ C  gtY +++g   ++ Cl+C +gt+  ++ga s+  C
       EFC37054.1 775 GTYSAGGASSCTNCGAGTYSSTVGgtnSSVCLNCVAGTYSFETGAASANVC 825
                      9********************666232566*****************9988 PP

  == domain 29  score: 14.0 bits;  conditional E-value: 3.5e-06
  Ephrin_rec_like   7 gletCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48 
                      +++ C++C+ gtY  + g+++C++C +g++ +++ ats + C
       EFC37054.1 821 SANVCQSCRAGTYS-SMGSSNCTNCTPGFYSTTVNATSSATC 861
                      5678*********7.58999*******************999 PP

  == domain 30  score: 21.8 bits;  conditional E-value: 1.3e-08
  Ephrin_rec_like   5 n.tgletCipCprgtYqneegqlsClaCPlgtt 36 
                      n t+++tCipC+ gt+ n+ g + C +CP+gt 
       EFC37054.1 854 NaTSSATCIPCSAGTFSNSTGASYCFQCPEGTN 886
                      448899***********************9875 PP

  == domain 31  score: -1.9 bits;  conditional E-value: 0.33
  Ephrin_rec_like  26 lsClaCP.lgtttk 38 
                      + C +C  l++tt+
       EFC37054.1 967 VFCMNCSfLNFTTS 980
                      67*****5555553 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9   4.5     8e-13   7.2e-09       2     118 .]    1911    2046 ..    1910    2046 .. 0.90

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 8e-13
                  HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS............ CS
         RGS    2 leslledqpgrslFreFlesefseenlsFwlaveefkka...keqeelkkkakeIyneylapsspkelnidkklreelekrleke............ 83  
                  l++++++  g++lF+ F+esefs enl +++  +e ++    ++  +l++ ++ I++ +++++s+ e+ni++++ ++ ++ ++              
  EFC37054.1 1911 LNEIINEVIGLQLFEVFCESEFSTENLYLYQLLKENENInseANIMKLSTFVRTIFELFIQRNSKYEVNIPSSVSTNFKHLINILestnielqqdet 2007
                  789***************************999999998333445555555**************************99998877889********* PP

                  .....STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS   84 .....qpsrklfeeaqeevfellekdsypkFlkselylrl 118 
                        +s+++f ++ ++++  le d +++F++ ++y+r+
  EFC37054.1 2008 nsplkLKSKEVFSDLLDQILLNLE-DTFSRFVTLDVYERY 2046
                  ****999**************996.89********99985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2065 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1287  (0.0717831); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        32  (0.00178482); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 2.16u 0.33s 00:00:02.49 Elapsed: 00:00:00.69
# Mc/sec: 9042.46
//
Query:       EFC37055.1  [L=405]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0038   16.8   0.2     0.0038   16.8   0.2    1.8  2  Carbam_trans_C   Carbamoyltransferase C-terminus
  ------ inclusion threshold ------
      0.046   13.9   1.1       0.61   10.4   0.3    2.6  2  Phospholip_A2_2  Phospholipase A2
      0.095   12.4   2.1       0.24   11.1   0.1    2.6  2  LisH_TPL         LisH-like dimerisation domain
        1.9    8.6   8.8        2.9    8.0   8.2    1.6  1  LicD             LicD family


Domain annotation for each model (and alignments):
>> Carbam_trans_C  Carbamoyltransferase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1      0.63   2.8e+03      35      52 ..     184     201 ..     157     229 .. 0.57
   2 !   16.8   0.2   8.6e-07    0.0038      40     112 ..     259     328 ..     254     340 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.63
  Carbam_trans_C  35 keemkeklnekikkResf 52 
                     k++m++ ln++  k+ s+
      EFC37055.1 184 KKKMRRSLNQEATKKVSY 201
                     334444444433333333 PP

  == domain 2  score: 16.8 bits;  conditional E-value: 8.6e-07
  Carbam_trans_C  40 eklnekikkResfrPfApsvleeeaeeyfeeekespymllvakvkeekreeipavtHvDgtaRvqtvkkeanp 112
                     + +n+++k+ ++ +  Ap+v+ e+    + ee+  +ym+ +++++    +e+  vt vDg+  vqtv+ ++++
      EFC37055.1 259 QMINTHLKSAKRVKQTAPTVVVETQPISMVEEEIPEYMMQMIPTN---WQEVCGVTTVDGAKQVQTVTVNNDE 328
                     789*******************99998888777788**9999887...679****************976543 PP

>> Phospholip_A2_2  Phospholipase A2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.3   0.00014      0.61      27      67 ..      29      71 ..      16      92 .. 0.79
   2 ?    1.2   0.0     0.099   4.4e+02       5      29 ..     216     240 ..     212     272 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00014
                     HHHHHHHHT-SSEE-TT-EETTEE..--SSS-EEBHHHHHHHH CS
  Phospholip_A2_2 27 dkCCreHdeceekiealetkyglt..nkklftlshCecdeefr 67
                      + C + d+c+++ +  e+  +++  n++l+t ++C+c+  f+
       EFC37055.1 29 YSACSSSDTCSSTNTDDESILQFFnfNNQLMTSISCQCEGGFE 71
                     5679999***99998888876665116799*********9886 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.099
                      -SSSBSS---SSTT---SSHHHHHH CS
  Phospholip_A2_2   5 TkwCGagniakseedlGkeketdkC 29 
                       +wC + ++++ e++ G++++t k 
       EFC37055.1 216 NMWCRSKTRSEMEKKKGRKTSTPKK 240
                      58************99999887654 PP

>> LisH_TPL  LisH-like dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.4      0.31   1.4e+03       8      15 ..      48      55 ..      48      56 .. 0.82
   2 ?   11.1   0.1   5.4e-05      0.24      10      20 ..     101     111 ..      96     114 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.31
    LisH_TPL  8 ilQFLkEn 15
                ilQF++ n
  EFC37055.1 48 ILQFFNFN 55
                9****866 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 5.4e-05
    LisH_TPL  10 QFLkEnsLHrt 20 
                 QFL+En+L+++
  EFC37055.1 101 QFLSENNLNQS 111
                 *********98 PP

>> LicD  LicD family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   8.2   0.00065       2.9      82     192 ..      99     223 ..      70     237 .. 0.59

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00065
        LicD  82 erkngngkn..........dsglyiDIfpldyvpkskll.ikkkkekeklkkklalkkslskkdkkelkkkillkkksfklkklnkkkklkkleklekk 169
                 ++++  ++n          ++ l+ D+  ld++++  ++  ++k+++++l+ ++ ++ +++ ++k+++++ ++ k +       +kkk+ + l+++ +k
  EFC37055.1  99 STQFLSENNlnqssvtislKTFLFEDVSSLDSLEEYTINlNQAKMVNNQLQITIPIRRDNTTRRKTRKSTAKSIKGEETAEDLERKKKMRRSLNQEATK 197
                 33333333344445899999**************98877544555444444444443455555555555555555555555555555555555555555 PP

        LicD 170 k...eydlkkseyiavlksgklrnke 192
                 k    +   +++++a+ +++ +r+k+
  EFC37055.1 198 KvsyIQVIANQQVLATSQNMWCRSKT 223
                 55554555555555555555554444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1957  (0.109153); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 2522.22
//
Query:       EFC37056.1  [L=262]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.15   12.6   0.1       0.41   11.2   0.0    1.7  2  Peptidase_C39_2  Peptidase_C39 like family


Domain annotation for each model (and alignments):
>> Peptidase_C39_2  Peptidase_C39 like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.29   5.1e+03       6      29 ..      17      43 ..      12      85 .. 0.62
   2 ?   11.2   0.0   2.3e-05      0.41     119     144 .]     154     178 ..     137     178 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.29
  Peptidase_C39_2  6 ynQldelpng.Ceptslamvlsyl..g 29
                     y+Q + +  g C + s+a +++ +   
       EFC37056.1 17 YAQSKLDISGsCVVCSIAYTINSKlsQ 43
                     555444444446666766666655432 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 2.3e-05
  Peptidase_C39_2 119 ftssgHlvvitGYdekgkrvyvnDPa 144
                      ++++ H+vv+ G+d+++ rv+++D++
       EFC37056.1 154 SRATTHAVVVLGIDDSN-RVTIADSY 178
                      67889************.******97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (262 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       615  (0.034302); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1657.68
//
Query:       EFC37057.1  [L=260]
Description: hypothetical protein NAEGRDRAFT_82035 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.8e-06   27.1   1.1    4.4e-06   26.4   1.0    1.5  1  CAP_C         Adenylate cyclase associated (CAP) C terminal
     0.0023   17.7   0.3     0.0071   16.1   0.1    1.9  1  TBCC          Tubulin binding cofactor C
  ------ inclusion threshold ------
      0.097   12.2   0.0        0.2   11.2   0.0    1.5  1  Phage_P2_GpE  Phage P2 GpE


Domain annotation for each model (and alignments):
>> CAP_C  Adenylate cyclase associated (CAP) C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   1.0   7.4e-10   4.4e-06      21      92 ..      75     147 ..      65     231 .. 0.78

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 7.4e-10
       CAP_C  21 keieieetelkqsvyifkCknstiqik.gKvnaitldnckkvsvvvdsvvSsvevincksvkvqvlgkvptis 92 
                   ++ e+ +++ s+yi +C+  + + + + ++ i+++nc+++++ + ++ ++ e+ nc+++++q +++v  +s
  EFC37057.1  75 PIVNGESDQKRVSLYIENCHYQIFDFSkQYFKRIVFENCSNCEIYLGKTFGGYEFSNCSNLTIQFTKNVENLS 147
                 455557778999************9962668***********************************9998665 PP

>> TBCC  Tubulin binding cofactor C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.1   1.2e-06    0.0071       5      52 ..      89     137 ..      83     143 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.2e-06
                 EE-S-BS-EEEE.-S--S-EEEES-BS-EEE----SS-EEEES-BS-EE CS
        TBCC   5 kisnlsdctiyl.ldplssvtiddcknctivlgpvsgsvfiedcencti 52 
                  i+n++    ++  + ++ + +++c+nc+i+lg++ g    ++c+n+ti
  EFC37057.1  89 YIENCHYQIFDFsKQYFKRIVFENCSNCEIYLGKTFGGYEFSNCSNLTI 137
                 5677777666664445678888999999999999999999999999887 PP

>> Phage_P2_GpE  Phage P2 GpE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   3.3e-05       0.2       4      20 ..     156     172 ..     156     174 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 3.3e-05
  Phage_P2_GpE   4 iAvvFHWspselddmsL 20 
                   i  +FH+++se+ +m +
    EFC37057.1 156 ISIIFHFKLSEMNEMRI 172
                   5689***********86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       956  (0.0533214); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1534.05
//
Query:       EFC37058.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.2e-34  118.7   2.6    3.2e-34  118.7   2.6    1.5  2  RNA_lig_T4_1  RNA ligase


Domain annotation for each model (and alignments):
>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.7   2.6   1.8e-38   3.2e-34       1     220 []      48     289 ..      48     289 .. 0.86
   2 ?   -3.3   0.0      0.38   6.7e+03     131     148 ..     341     358 ..     324     365 .. 0.48

  Alignments for each domain:
  == domain 1  score: 118.7 bits;  conditional E-value: 1.8e-38
  RNA_lig_T4_1   1 eaRGLfteenke...................erIvvRgydKFFNinEveetkweeieqktqgpyelteKenGclilis............alsdgkl 66 
                   e+RG++++++++                    rI++R+++KFFNinE+ee++ e+i+++  + ++++eK++G+l+ +             + s+  +
    EFC37058.1  48 ECRGIVFRNDQDddevniqqeniqndekkvkGRIISRKFHKFFNINEREESNVESINWR--RGFIVMEKMDGSLVSPLriirnddlndgiEDSNRVW 142
                   7********9999*****************88************************999..9***************9999***9999666666667 PP

  RNA_lig_T4_1  67 vvaSkhsleaeshaevgerllekklekegkte.eeLaeelleknlTavfElcddsfeehivaypeekagLyLhglnentp.efstesseevakfake 161
                   +++S  ++  ++  ++ ++++ +++e +++++  eL+e++ e+++T++fE+c++  e+++v  + ek+ L+L+++++ ++ e+++++  ++ ++ ++
    EFC37058.1 143 TFTSMLGF--TETGQAVDEFIYQEMEGRKRDKlFELCEYCEESGITPLFEFCSK--ENKVVIEH-EKTSLILLAFRNIESgEYMSFK--DTVNTLNK 232
                   88888888..5666666667777644333332379*******************..*******8.*************999999888..88899999 PP

  RNA_lig_T4_1 162 fgfiktklitlesle........evkkfleevaetgswegeeiEGfVvrckskkdffFklKfkepyy 220
                   f+  ++++++l++          +++k+l+e+ ++++     +EG+V+r+ ++     ++K+k+ +y
    EFC37058.1 233 FN-NPVPIVKLWKEYpnglkgveDANKLLKEIYAQKN-----VEGYVIRFYEGD----MYKVKTTWY 289
                   99.4777777777666766666688888888888888.....********7666....6******99 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.38
  RNA_lig_T4_1 131 ekagLyLhglnentpefs 148
                   e ++ +L+++ e+t+e++
    EFC37058.1 341 EVERRILLKIAETTKELK 358
                   233334444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       884  (0.0493056); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2935.43
//
Query:       EFC37059.1  [L=342]
Description: fibronectin, type-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-07   31.3   0.3    8.7e-05   22.1   0.0    2.2  2  Esterase_phd  Esterase PHB depolymerase
  ------ inclusion threshold ------
      0.039   14.1   1.7        4.4    7.6   0.0    2.7  3  Stork_head    Winged helix Storkhead-box1 domain
        0.1   12.4   0.0          2    8.3   0.0    2.6  3  DUF4817       Helix-turn-helix domain (DUF4817)


Domain annotation for each model (and alignments):
>> Esterase_phd  Esterase PHB depolymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.1   0.00048       2.9      94     157 ..      41     105 ..      33     157 .. 0.77
   2 !   22.1   0.0   1.5e-08   8.7e-05       5      69 ..     242     314 ..     239     340 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00048
  Esterase_phd  94 vdaarvyvaGlsaGaaladllalhypdvfaavalhsGlalGeaa.dvisaldvmrrGlrqapaaa 157
                   +    v v+G+saG+ +a      y   +   ++ +  ++ +a+ + ++a +    G  +    +
    EFC37059.1  41 IAQDSVSVSGVSAGGFFAVQFQVAYSKSLVGAGIFAAGPYYCAQgSLMTAEEQCMAGFANVDLNT 105
                   5566799**************************99988888886255677766666666555555 PP

  == domain 2  score: 22.1 bits;  conditional E-value: 1.5e-08
  Esterase_phd   5 lylppGarrga.mplvvmlhGctqsve....efaaGtrmnlladklGvvvlypeqslr.anaqkcwnwyk..d 69 
                   +y+p   +rg+   l v++hGc+q +      f +   mn  a+   ++++yp+ +    n  +c++w +   
    EFC37059.1 242 VYVPSSCQRGVsCRLHVVFHGCEQGASilgtTFVENIGMNEYAESNNIIMVYPQVTTGlLNEAGCFDWINfsY 314
                   79***99999625799********98533338999******************9876526889*****65322 PP

>> Stork_head  Winged helix Storkhead-box1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0         1     6e+03      51      67 ..     103     119 ..      82     124 .. 0.57
   2 ?    7.6   0.0   0.00073       4.4      32      56 ..     142     166 ..     136     170 .. 0.89
   3 ?    5.0   0.1    0.0046        28      29      77 ..     194     244 ..     184     246 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1
  Stork_head  51 eeviydaLgsLikerki 67 
                  + i++++++ ++++ i
  EFC37059.1 103 LNTIQSTITQYQSQGLI 119
                 44555566655555555 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00073
  Stork_head  32 letlveaLkkaypeiqiPseeviyd 56 
                  +++v++L+++y+++ iP+++++ +
  EFC37059.1 142 KQSVVQQLATQYQQLGIPQKNIVTN 166
                 689*******************986 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0046
  Stork_head  29 satletlveaLkkaypeiqiPseeviydaLgsLikerki...YhtgeGYfiv 77 
                 +++l+  ++ L++ y  i  P++e+i + L +  +++     Y tg+GY  v
  EFC37059.1 194 NCNLDGAYQVLNTIYGYI-KPKKEAIAANLITFEQTGNFsanYMTGNGYVYV 244
                 677777788888888665.79**************9988888*******876 PP

>> DUF4817  Helix-turn-helix domain (DUF4817)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0      0.84     5e+03      39      52 ..     104     117 ..      80     118 .. 0.56
   2 ?    0.8   0.0     0.072   4.3e+02      21      43 ..     144     166 ..     142     168 .. 0.87
   3 ?    8.3   0.0   0.00034         2      14      52 ..     192     229 ..     190     232 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.84
     DUF4817  39 stirrlvkkfeetG 52 
                 +ti+  + ++++ G
  EFC37059.1 104 NTIQSTITQYQSQG 117
                 66777776666655 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.072
     DUF4817  21 atqrafrrrFpnrsvPsrstirr 43 
                  +++++++++    +P+++ +++
  EFC37059.1 144 SVVQQLATQYQQLGIPQKNIVTN 166
                 589999*****999**9999987 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00034
     DUF4817  14 kngesvtatqrafrrrFpnrsvPsrstirrlvkkfeetG 52 
                  n++++  + + +++ ++    P +++i  +   fe+tG
  EFC37059.1 192 INNCNLDGAYQVLNTIYG-YIKPKKEAIAANLITFEQTG 229
                 5899**************.8889**************** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       481  (0.026828); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 2059.34
//
Query:       EFC37060.1  [L=503]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.1e-17   62.9  42.3    7.9e-07   29.3   1.3    9.3 11  LRR_4       Leucine Rich repeats (2 copies)
      3e-17   62.1  34.2    1.2e-08   34.5   4.2    6.3  7  LRR_8       Leucine rich repeat
    6.3e-14   50.8  25.1    0.00091   19.1   0.1   10.0  9  LRR_6       Leucine Rich repeat
    1.4e-05   24.7  14.4    0.00091   18.8   0.4    4.1  4  LRR_9       Leucine-rich repeat
     0.0018   18.2   0.0     0.0051   16.7   0.0    1.8  1  F-box-like  F-box-like
      0.003   17.9  34.8        0.8   10.5   0.3   10.6 11  LRR_1       Leucine Rich Repeat
  ------ inclusion threshold ------
      0.068   13.2   0.2       0.15   12.1   0.2    1.5  1  POC3_POC4   20S proteasome chaperone assembly proteins 3 and 


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   2.4      0.13   3.4e+02      21      30 ..     100     109 ..      90     164 .. 0.77
   2 ?    0.4   0.7      0.38   9.7e+02       3      30 ..     171     202 ..     171     212 .. 0.60
   3 ?    5.1   0.7     0.013        32      18      32 ..     212     230 ..     192     247 .. 0.66
   4 ?    4.0   1.3     0.029        74      21      39 ..     262     277 ..     242     287 .. 0.69
   5 !   16.2   2.0   4.2e-06     0.011       1      42 [.     265     307 ..     265     309 .. 0.81
   6 !   26.6   1.7   2.3e-09   5.8e-06       2      38 ..     290     325 ..     289     331 .. 0.90
   7 !   29.3   1.3   3.1e-10   7.9e-07       1      40 [.     311     351 ..     311     357 .. 0.88
   8 !   23.8   0.2   1.7e-08   4.2e-05       2      39 ..     336     374 ..     335     381 .. 0.91
   9 !   17.4   1.0   1.7e-06    0.0043       2      36 ..     360     395 ..     359     401 .. 0.86
  10 !   13.1   1.9   3.9e-05       0.1       2      37 ..     384     419 ..     383     423 .. 0.84
  11 !   14.3   1.9   1.7e-05     0.043       3      34 ..     408     443 ..     406     447 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.13
                 H-TT--EEE- CS
       LRR_4  21 klpnLkeLdL 30 
                 kl nLkeL+L
  EFC37060.1 100 KLSNLKELSL 109
                 5777777777 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.38
                 --EEE--SS---E-S-...HH.H-TT..--EEE- CS
       LRR_4   3 LevLdLsnNqltdipl...le.klpn..LkeLdL 30 
                 Le+L+ s+  l++ ++   l+ k+    Lk+L +
  EFC37060.1 171 LEHLSVSG--LSTNSWislLNsKFARnsLKSLKI 202
                 78888888..888888444334222234555554 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.013
                 -....HHH-TT--EEE-.- CS
       LRR_4  18 l....leklpnLkeLdLsg 32 
                      +++l+ L+eLd+s+
  EFC37060.1 212 AvfdlIGNLDCLTELDCSE 230
                 34332447********975 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.029
                 H.-TT--EEE-.-S-----G CS
       LRR_4  21 k.lpnLkeLdLsgNnlitdl 39 
                 + l+nL++L L +N    dl
  EFC37060.1 262 SlLTNLEYLCLMSN----DL 277
                 33999999988566....33 PP

  == domain 5  score: 16.2 bits;  conditional E-value: 4.2e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeL 42 
                 +nLe+L+L +N l   ++  l+++ +L+eL L  Nn+i++   L
  EFC37060.1 265 TNLEYLCLMSNDLVGSSFkhLQNMNHLTELIL-ANNKIENAAAL 307
                 7**********766666666999*******88.88899876555 PP

  == domain 6  score: 26.6 bits;  conditional E-value: 2.3e-09
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlitd 38 
                 +L++L L+nN++     l++ ++L++LdL +Nn+i+d
  EFC37060.1 290 HLTELILANNKIENAAALSSVTSLTHLDL-SNNYIRD 325
                 69************999************.6669987 PP

  == domain 7  score: 29.3 bits;  conditional E-value: 3.1e-10
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdld 40 
                 ++L++LdLsnN ++d +l  + +l nLk+L+L  N +i+++ 
  EFC37060.1 311 TSLTHLDLSNNYIRDEGLkdFCQLVNLKYLSLEYN-QIGSIG 351
                 79*************99988668*********777.**9994 PP

  == domain 8  score: 23.8 bits;  conditional E-value: 1.7e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 nL++L+L  Nq+ +i+   l+k+ +L++L+L +N +i+ +
  EFC37060.1 336 NLKYLSLEYNQIGSIGAnyLSKIVQLEQLNLARN-YIGEI 374
                 9****************99999*********888.99988 PP

  == domain 9  score: 17.4 bits;  conditional E-value: 1.7e-06
                 S--EEE--SS---E-S-HH..H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplle..klpnLkeLdLsgNnli 36 
                 +Le L+L+ N + +i+  +  +l  L+ L+L+ N +i
  EFC37060.1 360 QLEQLNLARNYIGEIGVENygNLQALRILNLNAN-NI 395
                 79***************66657*********888.44 PP

  == domain 10  score: 13.1 bits;  conditional E-value: 3.9e-05
                 S--EEE--SS---.E-S-HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqlt.diplleklpnLkeLdLsgNnlit 37 
                  L++L+L+ N++   + +l+ + +L +L++ +N +i+
  EFC37060.1 384 ALRILNLNANNIGdGLKFLACCNSLNQLYVASN-KIS 419
                 69******88***88888998888******888.654 PP

  == domain 11  score: 14.3 bits;  conditional E-value: 1.7e-05
                 --EEE--SS---E-S-HH....H-TT--EEE-.-S- CS
       LRR_4   3 LevLdLsnNqltdiplle....klpnLkeLdLsgNn 34 
                 L  L+ ++N++++ +l+     ++pnLk+L++s+Nn
  EFC37060.1 408 LNQLYVASNKISSKGLIDfckvSMPNLKVLTISNNN 443
                 777999999*9986664466788*********8874 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.1     0.015        39      14      33 ..      91     110 ..      82     111 .. 0.84
   2 ?   -2.4   0.1       1.7   4.3e+03       2       8 ..     196     202 ..     179     207 .. 0.59
   3 !   11.8   4.6   5.9e-05      0.15      24      61 .]     264     301 ..     245     301 .. 0.84
   4 !   23.4   7.9   1.4e-08   3.7e-05       2      61 .]     266     323 ..     265     323 .. 0.96
   5 !   34.5   4.2   4.8e-12   1.2e-08       2      61 .]     290     347 ..     290     347 .. 0.94
   6 !   27.7   2.3   6.7e-10   1.7e-06       2      61 .]     360     418 ..     359     418 .. 0.95
   7 !    6.7   0.0    0.0024       6.2      23      36 ..     430     443 ..     423     447 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.015
                 SEE-TTSSTT-TT--EEE-- CS
       LRR_8  14 tslddeaFkglsnLkvLdLs 33 
                  +l+++  ++lsnLk+L+L+
  EFC37060.1  91 LELQQKLITKLSNLKELSLG 110
                 57899999**********96 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.7
                 T-SEEE- CS
       LRR_8   2 nLtsLdL 8  
                 +L+sL +
  EFC37060.1 196 SLKSLKI 202
                 3444444 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 5.9e-05
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 l+nL++L L +N l   s + ++++++L++L L +N++
  EFC37060.1 264 LTNLEYLCLMSNDLVGSSFKHLQNMNHLTELILANNKI 301
                 89999999999999999999999999999999999987 PP

  == domain 4  score: 23.4 bits;  conditional E-value: 1.4e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nL++L L +N l + + +  +++++L++L L nN+++     a+s+ +sL++LdLs+N +
  EFC37060.1 266 NLEYLCLMSNDLVGSSFKHLQNMNHLTELILANNKIENAA--ALSSVTSLTHLDLSNNYI 323
                 9************************************995..****************86 PP

  == domain 5  score: 34.5 bits;  conditional E-value: 4.8e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+L nN++++    a +++++L++LdLsnN ++    + f +L +L++L L++N++
  EFC37060.1 290 HLTELILANNKIENA--AALSSVTSLTHLDLSNNYIRDEGLKDFCQLVNLKYLSLEYNQI 347
                 79***********86..5677779**********************************98 PP

  == domain 6  score: 27.7 bits;  conditional E-value: 6.7e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+ L+L +N++ +++ e   +l++L++L+L+ N++     + +++++sL +L++ +N++
  EFC37060.1 360 QLEQLNLARNYIGEIGVENYGNLQALRILNLNANNIGDG-LKFLACCNSLNQLYVASNKI 418
                 6999********************************995.48****************97 PP

  == domain 7  score: 6.7 bits;  conditional E-value: 0.0024
                 T-TT--EEE--SS- CS
       LRR_8  23 glsnLkvLdLsnNl 36 
                 +++nLkvL +snN+
  EFC37060.1 430 SMPNLKVLTISNNN 443
                 58999999999997 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.97   2.5e+03       3      11 ..     102     110 ..     100     113 .. 0.83
   2 ?    0.2   0.2      0.41   1.1e+03       3      15 ..     265     277 ..     264     281 .. 0.85
   3 !    9.3   0.1   0.00051       1.3       2      18 ..     288     304 ..     287     308 .. 0.85
   4 !   19.1   0.1   3.5e-07   0.00091       3      24 .]     311     332 ..     311     332 .. 0.93
   5 !   10.1   0.0   0.00026      0.68       4      20 ..     336     352 ..     333     356 .. 0.88
   6 ?    1.4   0.0      0.16   4.2e+02       5      21 ..     361     377 ..     360     378 .. 0.85
   7 !    5.7   0.4    0.0068        18       5      17 ..     385     397 ..     381     398 .. 0.91
   8 !    9.2   0.1   0.00053       1.4       2      24 .]     405     427 ..     404     427 .. 0.92
   9 ?    4.4   0.0     0.019        48       3      16 ..     432     445 ..     430     447 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.97
       LRR_6   3 thLteLdLs 11 
                 ++L+eL+L 
  EFC37060.1 102 SNLKELSLG 110
                 89****995 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.41
       LRR_6   3 thLteLdLsgNdI 15 
                 t+L++L L++Nd+
  EFC37060.1 265 TNLEYLCLMSNDL 277
                 79*********94 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00051
       LRR_6   2 nthLteLdLsgNdIgDe 18 
                  +hLteL L+ N+I ++
  EFC37060.1 288 MNHLTELILANNKIENA 304
                 58************987 PP

  == domain 4  score: 19.1 bits;  conditional E-value: 3.5e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 t+Lt+LdLs N I DeG++ ++
  EFC37060.1 311 TSLTHLDLSNNYIRDEGLKDFC 332
                 69****************9876 PP

  == domain 5  score: 10.1 bits;  conditional E-value: 0.00026
       LRR_6   4 hLteLdLsgNdIgDeGa 20 
                 +L++L+L +N+Ig  Ga
  EFC37060.1 336 NLKYLSLEYNQIGSIGA 352
                 7************9998 PP

  == domain 6  score: 1.4 bits;  conditional E-value: 0.16
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 L+ L+L+ N Ig  G+e
  EFC37060.1 361 LEQLNLARNYIGEIGVE 377
                 899******99987775 PP

  == domain 7  score: 5.7 bits;  conditional E-value: 0.0068
       LRR_6   5 LteLdLsgNdIgD 17 
                 L+ L+L+ N+IgD
  EFC37060.1 385 LRILNLNANNIGD 397
                 99**********9 PP

  == domain 8  score: 9.2 bits;  conditional E-value: 0.00053
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                 +++L  L +++N+I+ +G++ ++
  EFC37060.1 405 CNSLNQLYVASNKISSKGLIDFC 427
                 899****************9776 PP

  == domain 9  score: 4.4 bits;  conditional E-value: 0.019
       LRR_6   3 thLteLdLsgNdIg 16 
                 ++L+ L +s N++g
  EFC37060.1 432 PNLKVLTISNNNVG 445
                 79**********98 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.2      0.51   1.3e+03     110     149 ..      99     143 ..      88     154 .. 0.65
   2 !   10.3   1.1   0.00014      0.35      60     116 ..     261     317 ..     255     323 .. 0.86
   3 !   18.8   0.4   3.5e-07   0.00091      46     125 ..     315     395 ..     309     401 .. 0.91
   4 !    9.1   0.6   0.00034      0.86      58     127 ..     377     446 ..     376     461 .. 0.61

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.51
       LRR_9 110 aslkklellsllknp.....vtnkkeyrlyviyklkqlrlldfrk 149
                 ++l++l+ lsl  ++     +++k e+ ++v+  l+ + +++f k
  EFC37060.1  99 TKLSNLKELSLGPCAceyplIMTKLEHLERVVLNLRYINIVEFLK 143
                 556666666664443222234567777888888888888888865 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00014
       LRR_9  60 fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkle 116
                 + ll  l+ l l +n +v  + +  + + +l+el+l+nn++++ a l  ++sl +l+
  EFC37060.1 261 LSLLTNLEYLCLMSNDLVGSSFKHLQNMNHLTELILANNKIENAAALSSVTSLTHLD 317
                 568899999999999999999999999*****************9988877777765 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 3.5e-07
       LRR_9  46 tidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                  +dls+n ir+  l +f  l  lk l+l+ n+i  i+ +    + +le+l l+ n + e++  +   +l+ l++l l  n +
  EFC37060.1 315 HLDLSNNYIRDegLKDFCQLVNLKYLSLEYNQIGSIGANYLSKIVQLEQLNLARNYIGEIGV-ENYGNLQALRILNLNANNI 395
                 579******97669*********************************************985.9999999999999988876 PP

  == domain 4  score: 9.1 bits;  conditional E-value: 0.00034
       LRR_9  58 dgfPllkrlktlllnnnrivriaegle..evlPnleelvltnnelqeladld.Plaslkklellsllknpvtn 127
                 +++  l+ l++l ln n i   ++gl+   +  +l++l +++n++ + + +d   +s+++l++l++ +n v +
  EFC37060.1 377 ENYGNLQALRILNLNANNI---GDGLKflACCNSLNQLYVASNKISSKGLIDfCKVSMPNLKVLTISNNNVGK 446
                 5666677777777777754...445441134456777777777776666666234677777777777776654 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0     2e-06    0.0051       2      33 ..       7      40 ..       6      44 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2e-06
  F-box-like  2 srLPdE.iLlqIFsyLppsdLlrl.alVCrrWrr 33
                s +PdE i  +I+ y + + +l++ +lVC++W++
  EFC37060.1  7 SAIPDEvIFHRILPYFEYRWILNVgRLVCKYWNE 40
                679***55667************659******96 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       2.6   6.7e+03       1       8 [.     103     110 ..     103     114 .. 0.85
   2 ?    0.1   0.0      0.81   2.1e+03       1      11 [.     132     146 ..     130     163 .. 0.72
   3 ?   -2.1   0.1       4.3   1.1e+04       2       9 ..     171     178 ..     171     190 .. 0.76
   4 ?    2.5   0.3      0.13   3.4e+02       1      12 [.     196     207 ..     196     227 .. 0.80
   5 ?    2.9   0.2     0.099   2.5e+02       1      22 [.     266     287 ..     266     288 .. 0.85
   6 ?   -0.6   0.0       1.3   3.4e+03       1      12 [.     290     301 ..     290     308 .. 0.85
   7 !   10.5   0.3   0.00031       0.8       1      22 [.     312     333 ..     312     334 .. 0.85
   8 !    9.7   0.0   0.00058       1.5       1      22 [.     336     357 ..     336     358 .. 0.93
   9 ?    1.6   0.0      0.26   6.7e+02       1      14 [.     360     373 ..     360     382 .. 0.80
  10 ?    2.0   1.2      0.19   4.8e+02       2      14 ..     385     397 ..     384     428 .. 0.80
  11 ?    3.8   0.0      0.05   1.3e+02       1      11 [.     433     443 ..     433     458 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2.6
       LRR_1   1 nLrhLdLs 8  
                 nL++L L+
  EFC37060.1 103 NLKELSLG 110
                 8****995 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.81
       LRR_1   1 nLrhLdL....snnp 11 
                 nLr++++     n+ 
  EFC37060.1 132 NLRYINIveflKNCK 146
                 899999644446665 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 4.3
       LRR_1   2 LrhLdLsn 9  
                 L+hL +s+
  EFC37060.1 171 LEHLSVSG 178
                 89999865 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.13
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L ++n+ +
  EFC37060.1 196 SLKSLKICNCGI 207
                 69********97 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.099
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++L L +n l g +  ++qn
  EFC37060.1 266 NLEYLCLMSNDLVGSSFKHLQN 287
                 8*********998888888876 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 1.3
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L L nn +
  EFC37060.1 290 HLTELILANNKI 301
                 699*******87 PP

  == domain 7  score: 10.5 bits;  conditional E-value: 0.00031
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L+hLdLsnn + + +  +f+ 
  EFC37060.1 312 SLTHLDLSNNYIRDEGLKDFCQ 333
                 69*********98888888875 PP

  == domain 8  score: 9.7 bits;  conditional E-value: 0.00058
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++L L++n+++++++n++++
  EFC37060.1 336 NLKYLSLEYNQIGSIGANYLSK 357
                 8***************999875 PP

  == domain 9  score: 1.6 bits;  conditional E-value: 0.26
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L+ L+L +n ++ 
  EFC37060.1 360 QLEQLNLARNYIGE 373
                 5999******9854 PP

  == domain 10  score: 2.0 bits;  conditional E-value: 0.19
       LRR_1   2 LrhLdLsnnpllg 14 
                 Lr L+L+ n++++
  EFC37060.1 385 LRILNLNANNIGD 397
                 99****8877743 PP

  == domain 11  score: 3.8 bits;  conditional E-value: 0.05
       LRR_1   1 nLrhLdLsnnp 11 
                 nL++L +snn+
  EFC37060.1 433 NLKVLTISNNN 443
                 8*********8 PP

>> POC3_POC4  20S proteasome chaperone assembly proteins 3 and 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.2   5.7e-05      0.15      59     121 ..     287     350 ..     255     366 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.7e-05
                 EEEEEEEEES....HHHHHHHH---EEEEEEES-TTHCCHHHHHHHHHHHHHCCCTS-EEEEEEECG CS
   POC3_POC4  59 linyvyaidl....eeesvsdklsdvevvvllgnssdmkidivarqiaeLlnkkieppvlyvtissk 121
                 ++n      l    ++ ++   ls+v + ++l+ s++ ++d   + +++L+n k+ + + y +i+s 
  EFC37060.1 287 NMNHLTE--LilanNKIENAAALSSVTSLTHLDLSNNYIRDEGLKDFCQLVNLKYLSLE-YNQIGSI 350
                 3333333..2356688999999******************999****************.9999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.67u 0.28s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 3113.82
//
Query:       EFC37061.1  [L=389]
Description: hypothetical protein NAEGRDRAFT_59851 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       904  (0.0504211); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2410.25
//
Query:       EFC37062.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.4e-08   32.4  18.3    1.6e-07   31.4  18.3    1.4  1  FA_desaturase  Fatty acid desaturase
  ------ inclusion threshold ------
      0.034   14.3   0.2      0.084   13.0   0.2    1.6  1  Nanovirus_C8   Nanovirus component 8 (C8) protein


Domain annotation for each model (and alignments):
>> FA_desaturase  Fatty acid desaturase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4  18.3   1.8e-11   1.6e-07       6     235 ..      56     288 ..      50     298 .. 0.69

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 1.8e-11
  FA_desaturase   6 llla.lllglfllgitg.slaHeaaHgalfkkrklnrwlndllgal.lglplgisysawrisHlrHHay.tngpdeDpdlaplal........... 86 
                    l+++ l++g +     +    H+ +H+  +    ln++++ llg     ++++++    ++ H++HH+  +++  +  +  +  +           
     EFC37062.1  56 LPPVyLIFGGR-----WtLCYHNFLHQETS----LNPIVDLLLGVGlGHFLTFMPA---KHGHIKHHHFnYGEGSRKYSMDTTQDylapadilyrh 139
                    44343455554.....22677999998777....*****88887665555555566...8888888887533333333333333366667777666 PP

  FA_desaturase  87 .....srfeglfryllrlllgllvlgwllalvlglwlrrlarrrapsksrrrkwrllawlllllawlglwlalllllglalllwlvplllllflla 177
                         + ++++f+  ++ + ++++ +     + + ++ ++ + ++++k     w +  +++++l  ++l++++ll +++  l+ lv+++l+++++ 
     EFC37062.1 140 kqiqyRDPDYWFKSSPNRWVLFMRCS----VFDFHYISFYLKKKRDMK-----WKYAPMYFARL--VLLLAPFLLMNPIDYLIHLVMCRLVMTVIF 224
                    55555444444444555555555544....444458888888888877.....99999999999..************999955555555555555 PP

  FA_desaturase 178 lvlnyveHyg.....gdwgerqvetsasir.saswllnlltgnlnyHieHHlfPgvpwyrLpel 235
                    +v++ + H       + +++ +++   +i+     l ++ +++ n H +HH+fP+   + L ++
     EFC37062.1 225 MVFTTLAHEEgwfdsMVDKYYPFQKYVDINlVLEILIGYHVHHVNEHDNHHIFPKRDISMLEQV 288
                    555777776669999888889999999999889999999999999*********9888777766 PP

>> Nanovirus_C8  Nanovirus component 8 (C8) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   9.4e-06     0.084      89     127 ..     104     142 ..      94     148 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 9.4e-06
  Nanovirus_C8  89 ggylyhddyyyyegkkkveldiesdylkpdidfskdlev 127
                    g+  h+ + y eg +k+ +d   dyl+p    +++ ++
    EFC37062.1 104 HGHIKHHHFNYGEGSRKYSMDTTQDYLAPADILYRHKQI 142
                   48899************************9888777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       814  (0.0454013); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.25s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2208.99
//
Query:       EFC37063.1  [L=649]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-44  152.9  20.4    2.2e-44  152.1  20.4    1.3  1  ABC_membrane  ABC transporter transmembrane region
      6e-36  124.0   0.0    1.4e-35  122.8   0.0    1.6  1  ABC_tran      ABC transporter
    1.7e-05   24.3   2.3     0.0014   18.2   0.1    2.3  2  SMC_N         RecF/RecN/SMC N terminal domain
     0.0012   18.6   0.2      0.003   17.3   0.2    1.6  1  AAA_29        P-loop containing region of AAA domain
     0.0022   17.3   0.0      0.006   15.9   0.0    1.7  2  Zeta_toxin    Zeta toxin
     0.0071   16.1   0.0      0.017   14.9   0.0    1.7  1  AAA_15        AAA ATPase domain
     0.0092   16.3   0.1       0.12   12.6   0.1    2.2  1  AAA_22        AAA domain
  ------ inclusion threshold ------
      0.021   15.2   0.1      0.095   13.1   0.1    2.2  3  AAA_16        AAA ATPase domain
      0.022   14.7   0.0      0.057   13.3   0.0    1.7  1  RsgA_GTPase   RsgA GTPase
      0.028   14.8   0.2        2.3    8.7   0.0    3.1  3  AAA           ATPase family associated with various cellular 
       0.04   13.6   0.0       0.25   11.0   0.0    2.0  2  AAA_30        AAA domain
      0.049   12.8   0.0       0.15   11.2   0.0    1.5  1  G-alpha       G-protein alpha subunit
      0.055   13.6   0.4        0.2   11.7   0.3    2.0  1  DUF87         Helicase HerA, central domain
       0.12   11.8   0.0       0.26   10.8   0.0    1.5  1  AAA_7         P-loop containing dynein motor region
       0.16   12.2   0.4        1.4    9.2   0.4    2.4  1  SbcCD_C       Putative exonuclease SbcCD, C subunit
       0.45   10.0   4.7         12    5.4   0.1    2.8  2  E1-E2_ATPase  E1-E2 ATPase


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  152.1  20.4     2e-47   2.2e-44       2     271 ..      42     310 ..      38     314 .. 0.94

  Alignments for each domain:
  == domain 1  score: 152.1 bits;  conditional E-value: 2e-47
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSS...TCCHH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHH CS
  ABC_membrane   2 iliillailagvlsplfplvlgrildtlldk...gdpet.ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdt 94 
                   i++++  ++ g++  +f++++g +++++++    g      ++n +++++++++++ +il+++  +++ +  er+  rl++ +++++++q++++fd 
    EFC37063.1  42 IIGMVGYACFGAMPHIFNILMGELINIVVGAdvtG---IeNKINNLAMWMAIIAAIAAILTWIGGSMMAYSFERIGIRLKNAYIESLMKQEIGYFDM 135
                   67777788888888999999999999999754433...1567******************************************************* PP

                   SCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHH CS
  ABC_membrane  95 nsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgir 191
                   +++Gel+s +t+ +++++d++++klg  +q++++++ g+i++++++wk++lv+++++p+iil+++  +  ++ ++k+  k  ++as++a+E++ ++r
    EFC37063.1 136 KRTGELMSWMTESMEQIQDSFSNKLGRATQFFVQVILGIILALVFSWKMALVMISFAPVIILIMFSSGLASQLITKRTLKISNQASAIANEVIGAVR 232
                   ************************************************************************************************* PP

                   HHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHH CS
  ABC_membrane 192 tVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailf 271
                   tV+++  e++++++++++l + +  ++ +ai+ g+ ig++++ +  + al +w+G++l  ++e+ + +  +f ++  +l+
    EFC37063.1 233 TVRSMDSENKEINRYKEKLWSGNLLYVLRAIILGAPIGAQEISIWGVLALGMWWGGQLLVKSEIAFAN--MFRVFTLLLM 310
                   ********************************************************************..8888877665 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  122.8   0.0   1.2e-38   1.4e-35       1     137 []     378     533 ..     378     533 .. 0.96

  Alignments for each domain:
  == domain 1  score: 122.8 bits;  conditional E-value: 1.2e-38
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................... RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.................... 79 
                 lkn sl++k+g+ +a+vG++G+GKSt+++ll + ++p +G++ ldg++l+e++ ++lr ++g + qep lf+++ ++en                    
  EFC37063.1 378 LKNFSLTIKPGQAIALVGSSGSGKSTIISLLERFYEPLSGKVILDGNELSEIDPHWLRTHVGLVGQEPVLFSGT-IKENicysirktsndpfpseeeii 475
                 79************************************************************************.****************98888888 PP

                 ..HHHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 ..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  80 ..esdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                   ++ +++++++s l + +  +tv+++++ sLSgGqkqr+a+ar+++++p++lllDE+t+
  EFC37063.1 476 naAKAANAHDFISALPDGY--NTVLGERGVSLSGGQKQRIAIARSVIQNPEILLLDEATS 533
                 7777777999999999888..*************************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.4    0.0078       8.7      25      42 ..     389     406 ..     372     412 .. 0.74
   2 !   18.2   0.1   1.2e-06    0.0014     136     206 ..     504     570 ..     415     582 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0078
                 SEEEEEESTTSSHHHHHH CS
                 xxxxxxxxxxxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnlld 42 
                 +  a+vG+ GSGKs ++ 
  EFC37063.1 389 QAIALVGSSGSGKSTIIS 406
                 35789*********9985 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 1.2e-06
                 CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHCCC-S CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreemlekad 206
                 +LSgG+k+ +a+a       ++   + llDe  +aLD +  + v + l++  k    ivi++r  ++ ++d
  EFC37063.1 504 SLSGGQKQRIAIAR----SVIQNPEILLLDEATSALDTNSEAVVQDALNKLMKGRTTIVIAHRLSTIVNSD 570
                 79*****9988764....455666699************************************99988776 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.2   2.6e-06     0.003      15      39 ..     381     405 ..     374     408 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 2.6e-06
      AAA_29  15 htieidlkgatlltGpsGsGKSTll 39 
                  +++i++ +a+ l+G sGsGKST++
  EFC37063.1 381 FSLTIKPGQAIALVGSSGSGKSTII 405
                 5678888889**************8 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   5.4e-06     0.006      17      61 ..     389     433 ..     378     449 .. 0.92
   2 ?   -3.4   0.0       4.4     5e+03      73      98 ..     540     565 ..     530     571 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 5.4e-06
  Zeta_toxin  17 klillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPey 61 
                  +i l+G++G+GKs++++ll++  e+ ++ v ld+ +l e  P+ 
  EFC37063.1 389 QAIALVGSSGSGKSTIISLLERFYEPLSGKVILDGNELSEIDPHW 433
                 5899*********************************99999985 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 4.4
  Zeta_toxin  73 seltqkdaselvekllqeaiengyni 98 
                  +++q++  +l++  ++ +i ++ + 
  EFC37063.1 540 EAVVQDALNKLMKGRTTIVIAHRLST 565
                 33444444445555455555555544 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   1.5e-05     0.017      14      50 ..     378     415 ..     374     492 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.5e-05
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnk 50 
                 lk++++ +++     l+G  +sGKS+i+ +l+ F +  
  EFC37063.1 378 LKNFSLTIKPGqAIALVGSSGSGKSTIISLLERFYEPL 415
                 78899999998899********************9866 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.1   0.00011      0.12       5     104 ..     388     536 ..     384     564 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00011
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaee.................................................erpevv....fvtlpss 50 
                  + ++++G sG+GK+t +  l + ++  +   +                                                            +++++ 
  EFC37063.1 388 GQAIALVGSSGSGKSTIISLLERFYE--PLSGKvildgnelseidphwlrthvglvgqepvlfsgtikenicysirktsndpF----PseeeIINAAKA 480
                 6789****************999984..3333356666666666666666666666666666666666666666655532222....233445566666 PP

      AAA_22  51 tsskdllrellralglelkaerlsseell.ealeqalrarav...ielliiDEaqh.lr 104
                  +  d+ ++l   ++  l +   +   l   + ++ + ar+v   +e+l++DEa   l+
  EFC37063.1 481 ANAHDFISALPDGYNTVLGE---RGVSLSgGQKQRIAIARSViqnPEILLLDEATSaLD 536
                 66666666666666665555...444444466666666666666666666666666555 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       4.8   5.4e+03      72     118 ..     200     246 ..     188     268 .. 0.58
   2 ?   13.1   0.1   8.5e-05     0.095      25      50 ..     389     414 ..     375     559 .. 0.74
   3 ?   -2.8   0.0       6.3   7.1e+03      70     106 ..     593     629 ..     553     642 .. 0.57

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 4.8
      AAA_16  72 laqalareellrqlldeaesaeleawrekleealaavpelagaea..sr 118
                 + + l +++l+++   +  s++++a + +  +a++ v++++++ +  +r
  EFC37063.1 200 FSSGL-ASQLITKRTLK-ISNQASAIANEVIGAVRTVRSMDSENKeiNR 246
                 55555.33555555555.4445666666566666666666666556633 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 8.5e-05
      AAA_16  25 elvllsGesGvGKsslvrellralek 50 
                 +++ l+G sG+GKs+++  l r +e 
  EFC37063.1 389 QAIALVGSSGSGKSTIISLLERFYEP 414
                 7899*************666653333 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 6.3
      AAA_16  70 sa.laqalareellrqlldeaesaeleawrekleeala 106
                    +a+++ r++ +++ ++ +e ++++++  +le+ ++
  EFC37063.1 593 GGlYAELA-RKQMMKKQDSSEELTKVAEDEIALETPYK 629
                 33244444.77888888888888888888877777776 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   5.1e-05     0.057      97     120 ..     385     409 ..     356     419 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.1e-05
                  CTT.SEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  97 lkd.ktsvlvGqSGvGKStLinall 120
                  +k  + ++lvG+SG GKSt+i  l 
   EFC37063.1 385 IKPgQAIALVGSSGSGKSTIISLLE 409
                  5555899**************9885 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       2.2   2.5e+03      24      52 ..     130     158 ..     117     171 .. 0.73
   2 ?    2.0   0.0      0.23   2.5e+02       2      18 ..     392     408 ..     391     439 .. 0.87
   3 ?    8.7   0.0     0.002       2.3      47      98 ..     512     556 ..     475     572 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 2.2
                 HEEEEEETTTCSSSSTTHHHHHHHHHHHH CS
         AAA  24 vefleisgsellskyvgesekkirelfke 52 
                 + ++ ++ +  l +++ es+++i++ f++
  EFC37063.1 130 IGYFDMKRTGELMSWMTESMEQIQDSFSN 158
                 44566666666668999999999999976 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.23
                 EEESSTTSSHHHHHHHH CS
         AAA   2 llyGppGtGKTllakav 18 
                  l+G  G GK+++++ +
  EFC37063.1 392 ALVGSSGSGKSTIISLL 408
                 689*********98765 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.002
                 HHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  47 relfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkk 98 
                 r  +++   + +p il++DE+ +   ++      +e  v+++L + ++g ++
  EFC37063.1 512 RIAIARSVIQ-NPEILLLDEATSALDTN------SEAVVQDALNKLMKGRTT 556
                 3333333333.59************999......788899999999988876 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00023      0.25      17      50 ..     387     420 ..     381     425 .. 0.85
   2 ?   -0.5   0.0      0.79   8.8e+02      81     112 ..     506     546 ..     472     558 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00023
      AAA_30  17 gdrvavltGpAGtGKttalkalreaweaaggrvi 50 
                 + +  +l+G  G+GK+t+++ l++ +e   g+vi
  EFC37063.1 387 PGQAIALVGSSGSGKSTIISLLERFYEPLSGKVI 420
                 5567899*******************99977887 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.79
      AAA_30  81 k.........grarlepgtllivDEagmvdtkqlaallkaa 112
                           +r  +++ ++l+ DEa  +  ++ +a+++ a
  EFC37063.1 506 SggqkqriaiARSVIQNPEILLLDEATSALDTNSEAVVQDA 546
                 05555556654455677799999**9988666777776665 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00014      0.15      25      49 ..     390     414 ..     374     419 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00014
                 EEEEEESTTSSHHHHHHHHHHHCS- CS
     G-alpha  25 kllllGqseSGKsTilkqlkllykk 49 
                  + l+G+s+SGKsTi+  l+++y++
  EFC37063.1 390 AIALVGSSGSGKSTIISLLERFYEP 414
                 589*****************99976 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.3   0.00018       0.2      26      59 ..     391     422 ..     388     572 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00018
       DUF87  26 lAilgsTGsGKSntvavLleellekkgatililD 59 
                 +A +gs+GsGKS+ ++ Lle+ + ++ +  +ilD
  EFC37063.1 391 IALVGSSGSGKSTIIS-LLERFY-EPLSGKVILD 422
                 799*********8875.779999.7777777777 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00023      0.26      15      52 ..     370     407 ..     360     416 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00023
       AAA_7  15 ptvdtvrysyllelllknkkpvllvGptGtGKtviikd 52 
                 pt  ++++   ++l +k ++ + lvG++G+GK++ii+ 
  EFC37063.1 370 PTRPNIQVLKNFSLTIKPGQAIALVGSSGSGKSTIISL 407
                 6666777777789999*******************975 PP

>> SbcCD_C  Putative exonuclease SbcCD, C subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.4    0.0013       1.4      61      88 ..     520     547 ..     485     549 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0013
     SbcCD_C  61 epalrlvfLDEAFsklDeesiatllell 88 
                  +++++++LDEA s lD +s a + ++l
  EFC37063.1 520 IQNPEILLLDEATSALDTNSEAVVQDAL 547
                 35689*************9988877766 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.1     0.011        12     107     139 ..      73     105 ..      35     122 .. 0.87
   2 ?    5.2   1.0     0.012        13     102     163 ..     147     208 ..     137     226 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.011
                   ---HHHHHHHHHHHHHHHHHHHHHHHHHHS-ST CS
  E1-E2_ATPase 107 kktplqkkldklgkvlvpvvlliallvfliall 139
                   + t +++k+++l+ ++++++ ++a+l+++   +
    EFC37063.1  73 DVTGIENKINNLAMWMAIIAAIAAILTWIGGSM 105
                   68899**********************997655 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.012
                   --------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHHHS-TTH CS
  E1-E2_ATPase 102 eeakskktplqkkldklgkvlvpvvlliallvflialllgkslaeallralallvaaiPcaL 163
                   e+ ++ + ++ +kl + ++++v v+l i+l++++ + +    + +a + +l ++ + +   L
    EFC37063.1 147 ESMEQIQDSFSNKLGRATQFFVQVILGIILALVFSWKMALVMISFAPVIILIMFSSGLASQL 208
                   555677889999************************88777766666666666555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (649 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1296  (0.0722851); expected 358.6 (0.02)
Passed bias filter:                      655  (0.036533); expected 358.6 (0.02)
Passed Vit filter:                        92  (0.00513135); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.81u 0.35s 00:00:01.16 Elapsed: 00:00:00.49
# Mc/sec: 4018.25
//
Query:       EFC37064.1  [L=204]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0012   19.0  10.4      0.047   13.9   1.7    2.9  3  Ribosomal_S30  Ribosomal protein S30
  ------ inclusion threshold ------
      0.022   14.7   0.2       0.04   13.9   0.2    1.3  1  TF_AP-2        Transcription factor AP-2


Domain annotation for each model (and alignments):
>> Ribosomal_S30  Ribosomal protein S30
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   5.9e-05      0.53       7      17 ..       4      14 ..       1      22 [. 0.86
   2 !   13.9   1.7   5.3e-06     0.047      21      47 ..      48      75 ..      42      81 .. 0.78
   3 ?   -2.6   0.8      0.72   6.5e+03      50      50 ..     145     145 ..     125     162 .. 0.56

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 5.9e-05
                   TTTTHHHHHS- CS
  Ribosomal_S30  7 arAGKVrnqTP 17
                   arAGKVr  TP
     EFC37064.1  4 ARAGKVRRSTP 14
                   9*********9 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 5.3e-06
                   --.-------THHHHHHHHHHHTTSSS- CS
  Ribosomal_S30 21 Kq.ekkKkptGRakkRlqYnrRfvnvvv 47
                    q ++kK++ GR+k R q+n+ + + ++
     EFC37064.1 48 NQlNRKKEKNGRSKMRSQFNKYSTEQQQ 75
                   56469***************98877444 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.72
                    S CS
  Ribosomal_S30  50 k 50 
                    +
     EFC37064.1 145 N 145
                    2 PP

>> TF_AP-2  Transcription factor AP-2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.2   4.5e-06      0.04      18      71 ..      20      78 ..      15      83 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 4.5e-06
     TF_AP-2 18 kVTveEvrRRls...apE..cLNaSlLggvLrraKsKnggeslrekLekiglslpagrr 71
                ++T  Ev+RR +   + E  +L + l  + L r+K Kng +++r + +k+  + +++++
  EFC37064.1 20 HITLPEVNRRQKvlpPNEytSLCTKLYDNQLNRKKEKNGRSKMRSQFNKYSTEQQQQQQ 78
                799999*99954322334225667777789*******************9877766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (204 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1600  (0.0892409); expected 358.6 (0.02)
Passed bias filter:                      588  (0.032796); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.45
# Mc/sec: 1359.63
//
Query:       EFC37065.1  [L=146]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.073   13.1   3.7      0.087   12.9   3.7    1.3  1  CDK2AP    Cyclin-dependent kinase 2-associated protein


Domain annotation for each model (and alignments):
>> CDK2AP  Cyclin-dependent kinase 2-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   3.7   4.8e-06     0.087      52     110 ..      24      78 ..      18     144 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.8e-06
      CDK2AP  52 rveItaisssrgssagsgassgsnsasdyatssgslrkrdrqqskqqsaaalAyaneyk 110
                 +veI+++++ + +     ++++s+s s+ ++ss s +k+d+ q+k ++  a+A a+  k
  EFC37065.1  24 QVEIVPVKKESKAE----SDETSSSCSSVEESSVSPNKQDEAQKKINNLVAIARAVVSK 78 
                 99*****9887777....78899999*****************7777888888876555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1305  (0.0727871); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.23s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 1069.92
//
Query:       EFC37066.1  [L=831]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-05   24.7   0.7    3.6e-05   23.5   0.4    1.8  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
       0.32   11.0   5.3       0.39   10.7   0.5    2.8  2  PRP9_N         Pre-mRNA-splicing factor PRP9 N-terminus


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0      0.96   8.6e+03      34      58 ..     112     139 ..      98     142 .. 0.67
   2 !   23.5   0.4     4e-09   3.6e-05       6     165 ..     537     698 ..     535     714 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 0.96
  Guanylate_cyc  34 lLnelya...rfdelldekkvykvktiG 58 
                    ++n++y+   ++ + ++ +  +++kt G
     EFC37066.1 112 MVNDYYNgyiDMVDTIRPYIFERIKTFG 139
                    6666665222566666666699999988 PP

  == domain 2  score: 23.5 bits;  conditional E-value: 4e-09
  Guanylate_cyc   6 ydevtilFadIvgftalssahspievvklLnelyarfdelldekk.vykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskegl 100
                    +++++i+++ +++  + s + +   + +l+ +  +++ ++++  k   ++k   + +++v+  ++++ +++++ +++   + +  e++a++ ++++
     EFC37066.1 537 TKDCSIIYMTVPNLDEESYEYESGLLSSLISKALTSISTICKTCKaDFQIKSY-NEFIIVFTDKNPSVTALETSLKIVTLLNSLNETIAKDGHPRI 631
                    67889999999999999999999999999999999999999999967899988.66778888887999999999988655555559999999**** PP

  Guanylate_cyc 101 kvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagkiqv.seetyellkeeqfelter 165
                    k+   i +G++++g +G ++++ + + G  vn A  ++   +  ++ v  +++ ++  +++f ++ +
     EFC37066.1 632 KMCASITSGSTIMGNVGsKQMRYFAMVGPVVNRAKELNDFCNLLDVSVvCDHVTKQKAKDSFIFRPV 698
                    *****************5566666899*************999999995444444444577766655 PP

>> PRP9_N  Pre-mRNA-splicing factor PRP9 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.5   4.3e-05      0.39      76     147 ..     456     527 ..     448     531 .. 0.92
   2 ?    1.2   0.4     0.038   3.4e+02     108     127 ..     724     754 ..     696     802 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 4.3e-05
      PRP9_N  76 hEinlFledykkklksleklkeeadseelkdkekslekfkelleeikekekdseseeldinekkekYsmFss 147
                 +Ei+ F+ d   ++ ++ kl++e +++e  +   s++  ++++++ + ++k++ s+ +d ++k++k+    +
  EFC37066.1 456 SEIRAFIPDSILNQLEITKLMKEGEKKESYEPGLSFKASNHSMQKTNGESKSNLSQSSDGHSKISKHDAHAA 527
                 6************************************************99999999999999999877655 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.038
      PRP9_N 108 e...........kslekfkelleeikekekd 127
                 e           +++++f++  ++i e+e+ 
  EFC37066.1 724 EwlyeleqkkanAKFDEFQADFNKIFENETL 754
                 3444444444559999999999999887654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (831 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1573  (0.087735); expected 358.6 (0.02)
Passed bias filter:                      674  (0.0375927); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.83u 0.31s 00:00:01.13 Elapsed: 00:00:00.49
# Mc/sec: 5058.67
//
Query:       EFC37067.1  [L=530]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      1e-32  113.5  55.8    2.5e-26   92.5  28.4    2.1  2  MFS_1         Major Facilitator Superfamily
    2.3e-25   89.5   9.9    2.3e-25   89.5   9.9    2.5  3  Nodulin-like  Nodulin-like
  ------ inclusion threshold ------
        5.4    7.0  11.3        1.4    8.9   0.5    3.5  3  DUF2678       Protein of unknown function (DUF2678)


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.5  28.4   4.1e-30   2.5e-26       4     352 ..      50     442 ..      46     443 .. 0.78
   2 !   35.2  19.5   1.1e-12   6.5e-09       1     170 [.     305     493 ..     304     509 .. 0.83

  Alignments for each domain:
  == domain 1  score: 92.5 bits;  conditional E-value: 4.1e-30
       MFS_1   4 aaflsalarsilgpalplalaedlgispseigllltlyalgaavaslplGrlsdrfGrrr.vlllglllfalglllllf..a.....sslw.lllvlrv 93 
                 + +++a + ++++++ p  ++++++++  e++l+ t+  +g+  ++ +++ + d +G+r   l +g++lf++  +++++  +     ++ + ++ ++ +
  EFC37067.1  50 VMMIAAGTQYAFSSIGP-SIKQQFHLTQYEVNLIGTATNIGSTTGI-LFSLINDFIGPRVcSLAAGIVLFGSY-FIMSLtvSgaipeAGNYiAMSAFMF 145
                 45566666666777777.9*********************877666.567999********************.6666433245678667779****** PP

       MFS_1  94 lqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggllasslgWravfyilaivsllafvlfllllpeepperkrkspkeee.... 188
                 l G  +g+++ a+++  ++ fp+++rg+++glls++f++++++  l  +++    + ++ ++++ai++ +a+++ +  ++++++++++k +++      
  EFC37067.1 146 LVGNSSGGAYIASLTTSVKNFPEKDRGLVVGLLSSFFGISSAIFSLCFSVVF-RQSLPVYMFFCAIFGGVAVIILGTIFLDNNSSSEKKDTTPIVvkev 243
                 *****************************************99989888888.5568999999*******99977777767766666666655557888 PP

       MFS_1 189 ........................................kgtgpaplvpawkallkdpvlw.illialllfffgfsglltllplylqevlglsgllla 246
                                                         ++++  ++ + w++l +   +w i++i++l+++ g++++  l  +      g++g  ++
  EFC37067.1 244 esntetvsinsnladettglvvekeeglqvlseeeikeklAQDQIENINS-WRMLISFD-FWlIFIIIFLSIGSGITIVNNLGSIV-LAYGGYNG-QQT 338
                 88899999999999999999998887777777766666666666666666.88888777.67788888888888888877777773.55556663.333 PP

       MFS_1 247 glllallalvgailallagrlsdr....lgrrrrlllallllllaalglallavtssavllllvlvliGfglgfvfpsllalasdlappeeagtasglf 341
                   ++  +++ ++ ++l++g+lsd+     +  +r+++  l++++++++l+l+a+    + ++ +++++G+++g + +   ++ s+ ++p    +++gl+
  EFC37067.1 339 P-IVITFSISNCLGRLVFGWLSDKffspKKGITRMFFLALCIIIMSISLLLFAFV-PIPGFYPLIIIMGLCYGGILSVGPTYNSERFGP----KYFGLN 431
                 3.444455555555**********7654333777777777777777777777777.55677778888********************86....888888 PP

       MFS_1 342 ntagslggalg 352
                 +t++ ++++lg
  EFC37067.1 432 STLQLVATSLG 442
                 88888888777 PP

  == domain 2  score: 35.2 bits;  conditional E-value: 1.1e-12
       MFS_1   1 lllaaflsalarsilgpalplalaedlgispseigllltlyalgaavaslplGrlsdrf.....G.rrr.vlllglllfalglllllfasslwlllvlr 92 
                 +++++fls+ +  ++  +l   +  ++g    ++  ++ ++++  +++ l++G+lsd+f     G  r  +l l++++++++lll++f  +++ ++ l 
  EFC37067.1 305 IFIIIFLSIGSGITIVNNLG-SIVLAYGGYNGQQTPIVITFSISNCLGRLVFGWLSDKFfspkkGiTRMfFLALCIIIMSISLLLFAF-VPIPGFYPLI 401
                 57777777777777888888.77788885555555577779*****************666666566667788888888888555557.88889***** PP

       MFS_1  93 vlqGlgagalfpagaaliadwfpkeergraigllsagfslGa.ilgpllggllasslg..............Wravfyilaivsllafvlfll 170
                 +++Gl++g+++++g ++ ++ f ++  g+   l  +++slG+ ++  + +g ++ + +              + ++fyil +++++a++l l+
  EFC37067.1 402 IIMGLCYGGILSVGPTYNSERFGPKYFGLNSTLQLVATSLGSyAFSTGMAGSIY-QMNiipprtrtchgkecYLLTFYILSGLCVVALLLSLV 493
                 ************************999999999999999999999999999999.44468***************************887433 PP

>> Nodulin-like  Nodulin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   89.5   9.9   3.9e-29   2.3e-25       1     184 [.      41     226 ..      41     243 .. 0.90
   2 ?   -1.6   2.8      0.25   1.5e+03      94     179 ..     300     388 ..     295     395 .. 0.69
   3 ?   -1.7   0.0      0.27   1.6e+03     174     221 ..     447     495 ..     429     500 .. 0.54

  Alignments for each domain:
  == domain 1  score: 89.5 bits;  conditional E-value: 3.9e-29
  Nodulin-like   1 rWlvlvaaiwiqsiaGanylFsaySsalKsslgisQkqlnlLavakdlGkalGllsGllaevlplwvvllvgaamglvGYgvvwLvvtesiakl.py 96 
                   rW  l+   +++ +aG++y Fs++ +++K+   + Q ++nl++ a ++G + G+l  l+++ + + v  l++ +  +  Y+++ L+v++ i++  +y
    EFC37067.1  41 RWAALIVGSVMMIAAGTQYAFSSIGPSIKQQFHLTQYEVNLIGTATNIGSTTGILFSLINDFIGPRVCSLAAGIVLFGSYFIMSLTVSGAIPEAgNY 137
                   7999999999**********************************************************99999999999************87548* PP

  Nodulin-like  97 wllfllillaanseawlnTaslvtcirnFpe.srgvvvgllkgyaGlsaaiytqlyeailgsdaksllllvalvplvvslvvlylvrev 184
                   +++  +++l +ns   +  asl t+++nFpe  rg+vvgll ++ G+s+ai++  ++ ++ ++   ++++ a+   v ++++  + + +
    EFC37067.1 138 IAMSAFMFLVGNSSGGAYIASLTTSVKNFPEkDRGLVVGLLSSFFGISSAIFSLCFSVVFRQSLPVYMFFCAIFGGVAVIILGTIFLDN 226
                   *****************************97379**************************************97665554444444444 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.25
  Nodulin-like  94 lpywllfllilla.anseawl.nTaslvtcirnFpesrgvvvgllkgyaGlsaaiytqlyeailgs.daksllllvalvplvvslvvly 179
                     +wl+f++i+l+ + +++ + n +s+v++   ++  + ++v      + l+  ++  l   +++  +  + ++++al ++++s+ +l 
    EFC37067.1 300 FDFWLIFIIIFLSiGSGITIVnNLGSIVLAYGGYNGQQTPIVITFSISNCLGRLVFGWLSDKFFSPkKGITRMFFLALCIIIMSISLLL 388
                   57899999999873455665525689999988888888888877777778888888888877665525556677777777776666554 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.27
  Nodulin-like 174 slvvlylvreveklpkkkeersesavFl.vllvisvllavyllvvsils 221
                   s  +  ++ +++ +p ++++ + ++ +l +++++s l  v ll+  +l+
    EFC37067.1 447 STGMAGSIYQMNIIPPRTRTCHGKECYLlTFYILSGLCVVALLLSLVLH 495
                   5555556666666655555555555544044555554445555555544 PP

>> DUF2678  Protein of unknown function (DUF2678)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       0.4   2.4e+03      80     114 ..      29      62 ..      20      65 .. 0.73
   2 ?    8.9   0.5   0.00023       1.4      31      78 ..     172     219 ..     161     238 .. 0.89
   3 ?    1.8   2.3     0.037   2.2e+02      54      80 ..     365     391 ..     338     396 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.4
     DUF2678  80 fwyrqgdlepkfrnliyyilasivllclcanlyfh 114
                  wy+   l  k+r+    i++s++++   ++  f 
  EFC37067.1  29 TWYQSERL-RKLRRWAALIVGSVMMIAAGTQYAFS 62 
                 57765555.69999999999999999877666665 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00023
     DUF2678  31 nlvvggltsllvlvtvvssfvfpslppkplniffavcillisssvivl 78 
                  lvvg l+s++ + + + s+ f  +  ++l +++ +c ++  ++vi+l
  EFC37067.1 172 GLVVGLLSSFFGISSAIFSLCFSVVFRQSLPVYMFFCAIFGGVAVIIL 219
                 589******************************************998 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.037
     DUF2678  54 slppkplniffavcillisssvivlif 80 
                  ++  +   f+a+ci+++s+s +++ f
  EFC37067.1 365 PKKGITRMFFLALCIIIMSISLLLFAF 391
                 344445567889*******99887766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (530 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1149  (0.0640861); expected 358.6 (0.02)
Passed bias filter:                      583  (0.0325172); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.50
# Mc/sec: 3172.75
//
Query:       EFC37068.1  [L=724]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.6e-06   26.1   0.0        2.1    8.5   0.0    5.3  5  NHL       NHL repeat
      3e-05   23.7   0.0       0.32   10.5   0.0    3.4  4  SGL       SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
       0.47   10.4   6.3       0.18   11.8   2.4    2.4  2  cEGF      Complement Clr-like EGF-like


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0   0.00035       2.1       1      21 [.      39      59 ..      39      62 .. 0.91
   2 ?   -0.9   0.0      0.33     2e+03       8      25 ..     104     121 ..     103     124 .. 0.75
   3 !    8.2   0.0   0.00044       2.7       1      18 [.     155     172 ..     155     172 .. 0.95
   4 ?    1.1   0.0     0.082   4.9e+02       4      27 ..     215     239 ..     213     240 .. 0.79
   5 ?   -0.5   0.0      0.25   1.5e+03       2      20 ..     272     290 ..     271     296 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00035
                BSSEEEEEEETTTEEEEEECC CS
         NHL  1 fnyPhGvavdsnGdiyVaDse 21
                f++P++++ ds G++++aD++
  EFC37068.1 39 FYMPASTTQDSEGNLFIADTG 59
                89*****************64 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.33
                 EEETTTEEEEEECCCTEE CS
         NHL   8 avdsnGdiyVaDsenhrv 25 
                 a  snGd+y ++s+n  +
  EFC37068.1 104 AFASNGDLYWTESNNCII 121
                 55699***9899888755 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00044
                 BSSEEEEEEETTTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVa 18 
                 +++P+G++ + nGd++Va
  EFC37068.1 155 LRNPTGLTFTANGDLLVA 172
                 689**************8 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.082
                 EEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavd.snGdiyVaDsenhrvqv 27 
                 P+ + +  ++Gdiy a+++++r+++
  EFC37068.1 215 PQALLYHaPTGDIYWAEYGTNRIRK 239
                 5555566699************987 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 0.25
                 SSEEEEEEETTTEEEEEEC CS
         NHL   2 nyPhGvavdsnGdiyVaDs 20 
                 + P G ++d+ G++y ++ 
  EFC37068.1 272 SGPYGMVIDKAGNLYFTEV 290
                 67889********996655 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.15   8.7e+02     189     213 ..      45      69 ..      34      75 .. 0.83
   2 !    7.8   0.0   0.00036       2.1       7      80 ..     104     194 ..      99     220 .. 0.82
   3 !   10.5   0.0   5.3e-05      0.32       3      78 ..     216     311 ..     214     320 .. 0.87
   4 !    9.6   0.0    0.0001       0.6       4      72 ..     276     342 ..     273     369 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.15
         SGL 189 lavDaeGnvwvAvwgggkvvrfdpd 213
                  + D+eGn+++A  g + ++++d++
  EFC37068.1  45 TTQDSEGNLFIADTGYNVIRKIDTN 69 
                 5679999999999999999999876 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00036
         SGL   7 wdeeegaLlwvDilgqrihrldpatgketv...................ldtpesvGaiaprkdgrlvvasksglalldlasgeletladeee 80 
                 +++ +g L+w++  +  i ++++++g  t+                   + + ++ G+++  ++g l+va + +++ +d  +g ++tl+ + +
  EFC37068.1 104 AFASNGDLYWTESNNCIIRKYSKVDGIVTTiagialqcadggdgglasvATLRNPTGLTFT-ANGDLLVATSLSIRKID-VNGIITTLTYPNP 194
                 567899********************************9999999988877788******9.99**************9.5568888887743 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 5.3e-05
         SGL   3 EGpvwdeeegaLlwvDilgqrihrldpatgketv...................ldtpesvGaiaprkdgrlvvasksglall..dlasgeletlade 78 
                 ++ ++++ +g ++w +  ++ri +++++t+  ++                   ++++++ G++++ k+g+l++++  g+++     +sg+++t+a +
  EFC37068.1 216 QALLYHAPTGDIYWAEYGTNRIRKITSSTNIISTvagtviylgysgdngpanqAQLSGPYGMVID-KAGNLYFTEVWGMRIRfvSAQSGNISTIAGN 311
                 6778999999999999999999999999999999999999999999999999999999*******.99******99998877678899999998865 PP

  == domain 4  score: 9.6 bits;  conditional E-value: 0.0001
         SGL   4 GpvwdeeegaLlwvDilgqrihrldpatgketvldtpesvGaiaprkdgrlvvasksglalldlasgel 72 
                 G+v d + g L++++++g ri  +++++g+ +++  ++++G+  +  ++ l +a+ +   + +l++g+l
  EFC37068.1 276 GMVID-KAGNLYFTEVWGMRIRFVSAQSGNISTIAGNGQNGFSGD-GGDPLNAALGYVSGISQLNDGSL 342
                 55666.699*****************************9999999.77888888888888887777765 PP

>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   2.4     3e-05      0.18       4      20 ..     371     387 ..     371     387 .. 0.93
   2 ?   -2.2   0.1      0.72   4.3e+03      15      21 ..     456     462 ..     452     462 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3e-05
                 EE-STTEEE.ETTTEEE CS
        cEGF   4 CsCppGYkltpdGrsCt 20 
                 C+Cp GYk tpd   C+
  EFC37068.1 371 CECPTGYKFTPDQSACE 387
                 ************98885 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.72
                 TTTEEEE CS
        cEGF  15 dGrsCtD 21 
                 +  sCtD
  EFC37068.1 456 NSSSCTD 462
                 5569**9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (724 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       504  (0.0281109); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 4426.70
//
Query:       EFC37069.1  [L=303]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-70  236.2   0.1      3e-70  235.9   0.1    1.1  1  FtsJ      FtsJ-like methyltransferase
  ------ inclusion threshold ------
       0.21   11.4   0.0       0.31   10.8   0.0    1.2  1  E1-N      E1 N-terminal domain


Domain annotation for each model (and alignments):
>> FtsJ  FtsJ-like methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  235.9   0.1   3.4e-74     3e-70       1     177 []      21     195 ..      21     195 .. 0.99

  Alignments for each domain:
  == domain 1  score: 235.9 bits;  conditional E-value: 3.4e-74
                 CCCCHHHHHHHHHHHHT-S-TT-EEEECT-TTSHHHHHHCCT.T.-SEEEEEESSSSHHHTTEEEECS-CCCSSHHHHHCHCHHHSSEEEEEE--S-SS CS
        FtsJ   1 yrsRsayKLleidekfklfkpgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmaplpgvttiqgditdpetiekikealserkvdlvvsDgapdv 99 
                 +r+Rsa+KLl++de+f++f+++k++vDl+aaPG+wsqvl q+ +  + +v+vDlq+mapl+gv  iqgdit+++t+e+i  +++++k++lvv+Dgapdv
  EFC37069.1  21 WRARSAFKLLQVDEEFNIFENVKRAVDLCAAPGSWSQVLQQE-ED-AIIVSVDLQEMAPLEGVIEIQGDITSEKTAEEIVHHFKGKKAQLVVCDGAPDV 117
                 79****************************************.65.9**************************************************** PP

                 -CHHHHHHHHHCCCCHHHHCCHCCCCECCCEEEECCCHCCCHHHHHHHHHCCEEEEEEEE-SS--CCG-EEEEEEEEC CS
        FtsJ 100 sgvhdldeylqsqLllaalelalkllkpggtfvlkifrgeeteallkqlkkfFekvsvvkPkssrsesseeflvcrgf 177
                 +g+hd+dey+q+qL+laal++++++l++gg+fv+kifrg++++ l++q++ fFe+v+++kPkssr++s e+f+vc+gf
  EFC37069.1 118 TGMHDIDEYIQLQLILAALNITSHVLEEGGSFVSKIFRGKDITLLYSQCSIFFERVYCAKPKSSRNSSLESFVVCKGF 195
                 ****************************************************************************98 PP

>> E1-N  E1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   3.5e-05      0.31      10      81 ..      24      94 ..      14     112 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 3.5e-05
        E1-N 10 rmlaallGvded.easerlaravlvtaapGgkdaaavevvelllartvqvvtseaeeadlelviGevaartdl 81
                r    ll vde+ +  e ++rav + aapG  + +  ++ +++   +v++ +  + e  +e+  G++++   +
  EFC37069.1 24 RSAFKLLQVDEEfNIFENVKRAVDLCAAPGSWSQVLQQEEDAII-VSVDLQEMAPLEGVIEI-QGDITSEKTA 94
                4455688888764789**************88888888888887.45666666666666664.4777765554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (303 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2047.47
//
Query:       EFC37070.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1372  (0.0765241); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2030.18
//
Query:       EFC37071.1  [L=1108]
Description: hypothetical protein NAEGRDRAFT_82021 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.034   13.8   0.3       0.86    9.2   1.3    2.8  3  EcsC        EcsC protein family


Domain annotation for each model (and alignments):
>> EcsC  EcsC protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   1.3   4.8e-05      0.86      11      94 ..     191     276 ..     186     281 .. 0.82
   2 ?   -2.4   0.0      0.17   3.1e+03     181     197 ..     538     561 ..     510     580 .. 0.49
   3 ?   -1.1   0.0     0.069   1.2e+03      18      53 ..     554     627 ..     532     670 .. 0.52

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 4.8e-05
        EcsC  11 ekklekeasfleklskklqeklnaliPekvqekitkaieealeavleggeylvekkenkesiedlael..sLeqldelaaklakkr 94 
                 e+k e+e+s+ ++  + +++   + +P  ++ +i++ + +++e+v e++++ ++k+ n++si+++  +  s++++d+++++l++ +
  EFC37071.1 191 EEKIENENSKPSNDEELINTTEISSTPTTIETTINNNASNMVESVSESTSLENSKEINITSIQSIIRQynSIHEMDKQVEHLISLQ 276
                 5666666777777777777778899***********************8888888888888888766689*********9998876 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.17
        EcsC 181 v.......esqesgwleelikeia 197
                         e ++ + ++e+ikei 
  EFC37071.1 538 IieefseeENDQTDEIDEIIKEIT 561
                 022222222333333344444443 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.069
        EcsC  18 asfleklskklqeklnaliP......................................ekvqekitkaieeale 53 
                  +++++++++ +e ++a i+                                       +v ++it+++e++le
  EFC37071.1 554 DEIIKEITSATNEDIEANISesplsdssslsdnsqtkqsekeeeeednildviddistGEVAQAITTTTEDVLE 627
                 44444444444444444444444444444444444444444444444444444444444444445554444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3263  (0.181996); expected 358.6 (0.02)
Passed bias filter:                      313  (0.0174578); expected 358.6 (0.02)
Passed Vit filter:                       135  (0.0075297); expected 17.9 (0.001)
Passed Fwd filter:                        38  (0.00211947); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 2.01u 0.39s 00:00:02.40 Elapsed: 00:00:00.65
# Mc/sec: 5110.89
//
Query:       EFC37072.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       484  (0.0269954); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2246.73
//
Query:       EFC37073.1  [L=473]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   1.7e-140  467.4   0.0   1.9e-140  467.2   0.0    1.0  1  AdoHcyase      S-adenosyl-L-homocysteine hydrolase
    1.1e-81  272.7   4.2    1.6e-81  272.1   4.2    1.3  1  AdoHcyase_NAD  S-adenosyl-L-homocysteine hydrolase, NAD bindi
    7.9e-10   38.4   0.1    1.4e-09   37.6   0.1    1.3  1  2-Hacid_dh_C   D-isomer specific 2-hydroxyacid dehydrogenase,
    3.8e-05   24.1   0.4    0.00011   22.6   0.4    1.7  1  NAD_binding_7  Putative NAD(P)-binding
     0.0001   21.9   0.1    0.00018   21.1   0.1    1.4  1  IlvN           Acetohydroxy acid isomeroreductase, NADPH-bind
    0.00031   20.1   1.3     0.0013   18.1   1.3    1.9  1  THF_DHG_CYH_C  Tetrahydrofolate dehydrogenase/cyclohydrolase,
    0.00055   20.0   0.1     0.0012   18.9   0.1    1.5  1  Shikimate_DH   Shikimate / quinate 5-dehydrogenase
     0.0026   18.0   1.7     0.0057   16.9   0.4    2.3  2  TrkA_N         TrkA-N domain
  ------ inclusion threshold ------
      0.019   14.7   0.0      0.036   13.8   0.0    1.5  1  ELFV_dehydrog  Glutamate/Leucine/Phenylalanine/Valine dehydro


Domain annotation for each model (and alignments):
>> AdoHcyase  S-adenosyl-L-homocysteine hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  467.2   0.0  9.6e-144  1.9e-140       1     299 []      11     472 ..      11     472 .. 0.98

  Alignments for each domain:
  == domain 1  score: 467.2 bits;  conditional E-value: 9.6e-144
                 --B-S-GGGHHHHHHHHHHHHCC-HHHHHHHHHCTTT-TTTT-EEEEES--SHHHHHHHHHHHHTT-EEEEE-SSTTT--HHHHHHHCCTTEEEE--TT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   AdoHcyase   1 dykvkdislaefGrkeielaekempglmalreeyaeekplkgariaGslhmtiqtavLietLvalGaevrWasCnifstqdeaaaaiaeagvpvfawkg 99 
                 dy+vkdis+a++Grk+ie+aekempglma+r++y+eekpl+++ri+Gslhmt++tavLietL+++G ++rW+sCni+stqd+aaaaia+a++pvfawkg
  EFC37073.1  11 DYEVKDISQASLGRKRIEMAEKEMPGLMACRAKYGEEKPLNNVRISGSLHMTVETAVLIETLKTVGGNIRWCSCNIYSTQDDAAAAIAAANIPVFAWKG 109
                 7************************************************************************************************** PP

                 --HHHHHHHHHHCHS-SSTS-S-SEEEESSSHHHHHHHHHHHHH.H......S..SHHHHHHHHHHHHHHTT..THHCCCHCC--EEEE-SHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.x.xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxx RF
   AdoHcyase 100 etleeywwcieqalkwaedekepnlilDdGGDltllvhkgvkee.e.svlekeedeeeekvvlellkksleed.kkytellkkikGvseetttGvhrLy 195
                 etl eyw+c+ +alk+   +++p+li+DdGGD+tllvh+g+++e + s+le++   ee ++v++llk++l+e+   ++ ++ +ikGvseetttGvhrLy
  EFC37073.1 110 ETLVEYWECTWKALKFG-PNMGPQLIVDDGGDMTLLVHRGYQAEkDaSILESDGGVEELRIVNDLLKRILKEEpGFFHAIVPHIKGVSEETTTGVHRLY 207
                 **************986.5559********************6645699999*******************999************************* PP

                 HHHHTT---SEEEESTTSHHHCTTH.......................................................................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxx.......................................................................... RF
   AdoHcyase 196 elakkgkLlvpainvndsvtkskfD.......................................................................... 220
                  ++k+g+Ll+painvndsvtkskfD                                                                          
  EFC37073.1 208 AMQKQGTLLFPAINVNDSVTKSKFDniygcrhslldglnratdvmlagkecvvcgfgdvgkgcaealkgqgarvivteidpinalqacmagytvktied 306
                 *************************************************************************************************** PP

                 .........................................................................................S-HHHHHHHH CS
                 .........................................................................................xxxxxxxxxx RF
   AdoHcyase 221 .........................................................................................hpsfvmsasf 230
                                                                                                          hp+fvmsasf
  EFC37073.1 307 cletadvyvtatgnkdiitldhmkkmkdtaiicnighfdneidvlglktcegvkeinikpqvdqfvfpdghtilllaqgrlvnlgcatgHPAFVMSASF 405
                 *************************************************************************************************** PP

                 HHHHHHHHHHHHTTSSS-SSEEE--CHHHHHHHHHCCCCCT-------HHHHHCCTSXTTSXXSXTTXX CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   AdoHcyase 231 tnqvlaqielfkkekkyekkvyvlpkklDekvarlhleklgaklteltkeqaeyigveveGPfkpdhYr 299
                 tnq+laqi+l+k  ++y+ +vy+lpk lDe+varlhleklga+lt+lt++qa+yigv+++GP+k+dhYr
  EFC37073.1 406 TNQTLAQISLWK--DTYAVGVYTLPKVLDEEVARLHLEKLGARLTKLTDSQADYIGVSQNGPYKADHYR 472
                 ************..569***************************************************9 PP

>> AdoHcyase_NAD  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  272.1   4.2     8e-85   1.6e-81       1     162 []     233     395 ..     233     395 .. 0.99

  Alignments for each domain:
  == domain 1  score: 272.1 bits;  conditional E-value: 8e-85
                    HHHHHCCCCCHHHHHHH-S--TTSEEEEE--SHHHHHHHHHHHHCT-EEEEE-S-HHHHHHHHCTT-EE--HHHCTTT-SEEEE-SSSSSSB-HHH CS
  AdoHcyase_NAD   1 nlygcreslvdgikratdvllaGkvavvaGyGdvGkGcaaslkglGarvivtevdPicalqaameGfevvtleevvkkadivvtttGnkdiitleh 96 
                    n+ygcr+sl+dg++ratdv+laGk +vv+G+GdvGkGca++lkg+Garvivte+dPi+alqa+m G+ v+t+e+ +++ad++vt+tGnkdiitl+h
     EFC37073.1 233 NIYGCRHSLLDGLNRATDVMLAGKECVVCGFGDVGKGCAEALKGQGARVIVTEIDPINALQACMAGYTVKTIEDCLETADVYVTATGNKDIITLDH 328
                    89********************************************************************************************** PP

                    HCCS-TTEEEEE-SSTTTTBTHHHHHTT.T-EEEEEETTEEEEE-TTS-EEEEEGGGSBCHHHTS-- CS
  AdoHcyase_NAD  97 lkkmkddaivcniGhfdseidvaalean.alkkeevkpqvdrvtlkdgkkiillaeGrllnlgcatg 162
                    +kkmkd+ai+cniGhfd+eidv +l++  ++k +++kpqvd+++++dg++i+lla+Grl+nlgcatg
     EFC37073.1 329 MKKMKDTAIICNIGHFDNEIDVLGLKTCeGVKEINIKPQVDQFVFPDGHTILLLAQGRLVNLGCATG 395
                    **************************99799**********************************97 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   0.1   7.1e-13   1.4e-09      33     127 ..     252     342 ..     237     344 .. 0.92

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 7.1e-13
                   -GTTSEEEEES-SHHHHHHHHHHHHTT-EEEEESSSHHHHHCHHHHTCEECSHHHHHHH-SEEEE-S--STTTTTSBSHHHHHCSTTTEEEEESS CS
  2-Hacid_dh_C  33 elsgktvGiiGlGrIGqavakrlkafgmkviaydrskkkeeeeeelgvelvsleellaesDivslhlpltpetrhlinaeelakmkkgailiNta 127
                    l+gk+  + G+G++G+  a+ lk+ g++vi+++  + +  ++   g+++ ++e+ l+++D+ + ++     ++++i+ ++++kmk++ai+ N++
    EFC37073.1 252 MLAGKECVVCGFGDVGKGCAEALKGQGARVIVTEIDPINALQACMAGYTVKTIEDCLETADVYVTATG----NKDIITLDHMKKMKDTAIICNIG 342
                   689*********************************998888999999*************9887765....999******************98 PP

>> NAD_binding_7  Putative NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.4   5.4e-08   0.00011       5      97 ..     253     347 ..     251     351 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 5.4e-08
  NAD_binding_7   5 lkgkkvlvvGgGevAarkvrklleagakvtvvapevkeeleelvk.laeeelekdlegadlviaatddrelner.iaeaakarrilvnvadkpel 97 
                    l gk+++v G G+v+   ++ l  +ga+v+v   +  ++l+  +  ++ +++e+ le ad+ ++at ++++ +   ++++k+  i +n+    ++
     EFC37073.1 253 LAGKECVVCGFGDVGKGCAEALKGQGARVIVTEIDPINALQACMAgYTVKTIEDCLETADVYVTATGNKDIITLdHMKKMKDTAIICNIGHFDNE 347
                    789****************************888854555544444678889999***********99987554377777888888887666555 PP

>> IlvN  Acetohydroxy acid isomeroreductase, NADPH-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.1   8.9e-08   0.00018       2      67 ..     253     317 ..     252     349 .. 0.87

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 8.9e-08
                 HHTS-EEEES-SHHHHHHHHHHHHTT--EEEEE-TT-HHHHHHHHTT-EEEEHHHHHHT-SEEEE- CS
        IlvN   2 lkgkkiaviGyGsqGhaqalnlrdsgldvvvglregsksvkkAkeegfevltvaeavkkadvvmil 67 
                 l gk+ +v G+G  G+  a+ l+ +g  v+v+  +   ++ +A  +g++v+t+++  ++adv ++ 
  EFC37073.1 253 LAGKECVVCGFGDVGKGCAEALKGQGARVIVTEIDPI-NALQACMAGYTVKTIEDCLETADVYVTA 317
                 889****************************988877.7788999****************97765 PP

>> THF_DHG_CYH_C  Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   1.3   6.4e-07    0.0013      28     111 ..     247     345 ..     233     367 .. 0.76

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 6.4e-07
                    HHCT---TT-EEEEE---TTTHHHHHHHHHCT............T-EEEEE-TTS.CCHHHHHCCSSEEEE-SS-TT-B-GGGS...-TT-EEEE- CS
  THF_DHG_CYH_C  28 ketgielegkkvvvvGrsnivgkplallLlek............natVtvchskt.kdlaeitreadivvvavGkpelikaemv...kegavviDv 107
                    ++t++ l+gk++vv G ++ vgk  a  L+ +            na   ++   t k +++ +++ad+ v+a+G++++i+ +++   k+ a++ ++
     EFC37073.1 247 RATDVMLAGKECVVCGFGD-VGKGCAEALKGQgarvivteidpiNALQACMAGYTvKTIEDCLETADVYVTATGNKDIITLDHMkkmKDTAIICNI 341
                    5688999*********987.9*********9844555555555555555555556789999*******************9987333668899999 PP

                    --EE CS
  THF_DHG_CYH_C 108 Ginr 111
                    G+  
     EFC37073.1 342 GHFD 345
                    9754 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.1   6.1e-07    0.0012      10      99 ..     253     333 ..     245     342 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 6.1e-07
                   .TT-EEEEES-SHHHHHHHHHHHCCT-CEEEEEESSHHHHHHHHHHHT.ET-EEEEGCGHHHHHHT-SEEEE-SSSSS-SB-HHHHHCCH CS
  Shikimate_DH  10 lkekkvlliGaGemaelvakhLlakgvkkvvvaNRtlerakelaeelkgeeiealkleelkellaeadvvisataseepilekeeveeal 99 
                   l++k+ ++ G G +++  a++L  +g++ v+v+  +++  ++l   + g+     +++ ++++l+ adv ++at+ +++i + +++++++
    EFC37073.1 253 LAGKECVVCGFGDVGKGCAEALKGQGAR-VIVT--EIDPINALQACMAGY-----TVKTIEDCLETADVYVTATGNKDII-TLDHMKKMK 333
                   789999**********************.6666..678888887778666.....899999**************98865.555555554 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.9   3.9e+03      35      81 ..      51     100 ..      46     103 .. 0.66
   2 !   16.9   0.4   2.9e-06    0.0057       2      41 ..     259     298 ..     258     346 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.9
                 HHHHHTT.SEEEES-TTSHHHHHHT..TGGGESEEEE-SSSHHHHHHHHH CS
      TrkA_N  35 eelreeg.levvvgdatdeevLeea..giekadaviaatgddeanilavl 81 
                 +++r  g l+  v  a   e+L+    +i  +++ i  t+dd+a ++a++
  EFC37073.1  51 NNVRISGsLHMTVETAVLIETLKTVggNIRWCSCNIYSTQDDAAAAIAAA 100
                 55555555666666666677777775557778888888888888887776 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 2.9e-06
                 EEES-SHHHHHHHHHHHHTTEEEEEEESSHHHHHHHHHTT CS
      TrkA_N   2 iiiGlGrvGrslaeeLseggkdvvvidkdeerveelreeg 41 
                 +++G+G+vG+  ae L+ +g +v+v + d+ ++ ++   g
  EFC37073.1 259 VVCGFGDVGKGCAEALKGQGARVIVTEIDPINALQACMAG 298
                 8*****************6657******996665554444 PP

>> ELFV_dehydrog  Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.8e-05     0.036      13      59 ..     236     282 ..     234     349 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.8e-05
                    HHHHHHHHHHHHTTTS-STTEEEEEE--SHHHHHHHHHHHHCT-EEE CS
  ELFV_dehydrog  13 GvvyyveemlkklkldslegkrvaisGsGnvgsyaallltelgakvv 59 
                    G+++ +   l+++    l+gk++++ G+G+vg+ +a+ l+ +ga+v+
     EFC37073.1 236 GCRHSLLDGLNRATDVMLAGKECVVCGFGDVGKGCAEALKGQGARVI 282
                    5666655566664444799************************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (473 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       460  (0.0256568); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 2949.73
//
Query:       EFC37074.1  [L=510]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (510 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1133  (0.0631937); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 3413.21
//
Query:       EFC37075.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.04   13.6   1.8      0.094   12.4   0.5    2.0  2  Retrotran_gag_2  gag-polypeptide of LTR copia-type


Domain annotation for each model (and alignments):
>> Retrotran_gag_2  gag-polypeptide of LTR copia-type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.5   5.2e-06     0.094      42      88 ..      43      89 ..      39      94 .. 0.91
   2 ?   -0.1   0.0     0.039   6.9e+02      55      75 ..      95     115 ..      89     124 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 5.2e-06
  Retrotran_gag_2 42 ekksaankltlrkklfslkmkegesvadhinkleelvneLsalgvki 88
                     e+++a++ l+l++   ++++ e++s+a+ i kl++l +++ +l+v +
       EFC37075.1 43 EREEASSTLQLKRSVNRFQIPETKSIAHQIMKLRKLSRKMHELKVSL 89
                     67888999********************************9998865 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.039
  Retrotran_gag_2  55 klfslkmkegesvadhinkle 75 
                      k++s+ +++g+ +++ +nk+ 
       EFC37075.1  95 KFESINYSNGDEMKQVMNKIL 115
                      789999999999999999864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       953  (0.0531541); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.48
# Mc/sec: 1385.29
//
Query:       EFC37076.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0029   17.6   3.6       0.01   15.8   3.6    1.8  1  CENP-F_leu_zip   Leucine-rich repeats of kinetochore protein 
  ------ inclusion threshold ------
      0.013   15.6   5.0       0.64   10.1   0.6    2.3  2  TolA_bind_tri    TolA binding protein trimerisation
      0.013   15.7   1.6       0.33   11.2   0.3    2.1  2  Herpes_UL14      Herpesvirus UL14-like protein
      0.019   15.4   0.3        4.9    7.7   0.0    2.6  2  NPV_P10          Nucleopolyhedrovirus P10 protein
      0.022   14.4   2.6      0.035   13.7   2.6    1.3  1  Snf7             Snf7
      0.059   13.4   2.3       0.23   11.5   0.7    2.1  2  DUF1664          Protein of unknown function (DUF1664)
      0.062   13.2   0.8         30    4.6   0.1    3.3  3  HU-CCDC81_bac_2  CCDC81-like prokaryotic HU domain 2
      0.086   12.9   3.6        1.9    8.6   1.3    2.3  2  TMF_DNA_bd       TATA element modulatory factor 1 DNA binding
        0.1   10.7   2.8       0.13   10.5   2.8    1.0  1  FPP              Filament-like plant protein, long coiled-coi
       0.12   12.0   2.9       0.17   11.6   1.4    1.9  2  RPW8             Arabidopsis broad-spectrum mildew resistance
       0.16   12.5   6.5      0.065   13.8   2.9    1.9  2  APG6_N           Apg6 coiled-coil region
       0.39   11.4   4.2        1.5    9.5   1.8    2.4  2  SlyX             SlyX
        2.1    7.1   4.2        2.4    6.9   0.1    2.1  2  LptF_LptG        Lipopolysaccharide export system permease Lp


Domain annotation for each model (and alignments):
>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   3.6   7.6e-06      0.01      16      98 ..      33     117 ..      12     133 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 7.6e-06
  CENP-F_leu_zip  16 erkadsLkdkvenLerelemseenqekvileaEtskaevet..lkeeieelaeelreleldLvalrsekeeLekelqkkqervse 98 
                     ++ka+ L+ +v+++e+ le+++ +  +v++ +   k+e      +e i+ l+ +l      L++l++ ke L+ ++ +k +++++
      EFC37076.1  33 NQKANRLQYQVDSMEAKLENLGCDILHVEMVVSHLKNEFRYakTNEIIDSLRYRLDAQGYHLQNLKESKEYLAMDIHDKLREIDS 117
                     45666777777777777777777777777777777777665224456999***********************999998888765 PP

>> TolA_bind_tri  TolA binding protein trimerisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.6   0.00047      0.64       3      45 ..      12      54 ..      10      61 .. 0.90
   2 ?    7.2   0.3    0.0037       5.1      34      71 ..      80     117 ..      72     119 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00047
  TolA_bind_tri  3 edrvarLErilearsqlllelqqqlealqqelreLRGqiEelq 45
                   ++ +++LE  l+  +++ ++  q+ ++lq +++++  ++E l 
     EFC37076.1 12 KKEIDELEFELKEFDRMEMQFNQKANRLQYQVDSMEAKLENLG 54
                   67899******************************99999875 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0037
  TolA_bind_tri  34 lreLRGqiEelqyqleqleerQrdlYldlDerlrklea 71 
                    +++LR  ++ + y+l++l+e    l  d++  lr++ +
     EFC37076.1  80 IDSLRYRLDAQGYHLQNLKESKEYLAMDIHDKLREIDS 117
                    799***************************99999865 PP

>> Herpes_UL14  Herpesvirus UL14-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0     0.048        66      47      80 ..      14      48 ..       7      56 .. 0.81
   2 ?   11.2   0.3   0.00024      0.33      53     118 ..      65     130 ..      58     135 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.048
  Herpes_UL14 47 aeedlkaqlrsdaRles.vrrkikriqakveeqae 80
                    +l+ +l+   R+e+  ++k++r+q +v+   +
   EFC37076.1 14 EIDELEFELKEFDRMEMqFNQKANRLQYQVDSMEA 48
                 5578899999999**984699******99997655 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00024
  Herpes_UL14  53 aqlrsdaRlesvrrkikriqakveeqaelrsiLkanRrylspkllerldatedkllekedsLeeav 118
                   +l+ + R + ++  i  ++ +++ q    + Lk  + yl+ ++ ++l + +   l+ +d Le   
   EFC37076.1  65 SHLKNEFRYAKTNEIIDSLRYRLDAQGYHLQNLKESKEYLAMDIHDKLREIDSVTLDFIDDLERNL 130
                  5789999******************************************************99865 PP

>> NPV_P10  Nucleopolyhedrovirus P10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.1     0.014        19      16      60 ..      32      52 ..       7      63 .. 0.51
   2 ?    7.7   0.0    0.0035       4.9      12      64 ..      56     118 ..      53     128 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.014
     NPV_P10 16 vddkVdalqqqvddvqenlpdvtelnekLdaqsaqLaeletkven 60
                 ++k                         ++++ q++++e+k+en
  EFC37076.1 32 FNQKA------------------------NRLQYQVDSMEAKLEN 52
                23333........................4444444455555554 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0035
     NPV_P10  12 dikavddkVdalqqqvddvqenlpdvtelnekLdaqsaqLaelet...........kvenIqdi 64 
                 di +v+  V+ l+++    ++n   ++ l  +Ldaq   L++l++           k+ +I+++
  EFC37076.1  56 DILHVEMVVSHLKNEFRYAKTNE-IIDSLRYRLDAQGYHLQNLKEskeylamdihdKLREIDSV 118
                 66667777777777777777764.5689****************98888777777777777665 PP

>> Snf7  Snf7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   2.6   2.5e-05     0.035       5      83 ..      10     103 ..       6     106 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.5e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTT-...............HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        Snf7   5 sLrkaerkldkkqeslekkikkleaelkklakkgn...............kdralllLKqkkryekqldqldnqlanleqvslaienlksnkev 83 
                  L+k++++l+ + +++++ + + ++++ +l+ + +                +++   LK   ry k  + +d+ +++l+++ ++++nlk  ke 
  EFC37076.1  10 YLKKEIDELEFELKEFDRMEMQFNQKANRLQYQVDsmeaklenlgcdilhVEMVVSHLKNEFRYAKTNEIIDSLRYRLDAQGYHLQNLKESKEY 103
                 57777777777777777777777777777777766777777799999999***************************************99886 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.7   0.00017      0.23      57     116 ..      11      70 ..       3      78 .. 0.70
   2 ?    1.5   0.0      0.21   2.9e+02      64     117 ..      83     134 ..      72     138 .. 0.51

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00017
     DUF1664  57 laatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveglesk 116
                 l++  ++L+ ++++ d+   + ++ ++ ++ +v++++ +l+++g d+ +v+ +v++l+++
  EFC37076.1  11 LKKEIDELEFELKEFDRMEMQFNQKANRLQYQVDSMEAKLENLGCDILHVEMVVSHLKNE 70 
                 444455666666666666666666677777888888888888888888888888888765 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.21
     DUF1664  64 Lssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeavegleskl 117
                 L  r+d  + +l++ ke ++ ++ ++++  ++++++   ++ ++++ ++l++k+
  EFC37076.1  83 LRYRLDAQGYHLQNLKESKEYLAMDIHDKLREIDSVT--LDFIDDLERNLDGKI 134
                 4445555555555555555555544444333333333..344555555666655 PP

>> HU-CCDC81_bac_2  CCDC81-like prokaryotic HU domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.022        30      14      41 ..       3      30 ..       1      31 [. 0.90
   2 ?    0.8   0.0      0.34   4.7e+02      13      35 ..      30      52 ..      26      55 .. 0.81
   3 ?    4.6   0.0     0.022        31      28      58 ..     107     137 ..     102     144 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.022
  HU-CCDC81_bac_2 14 syeeAlqkiekeveelkqeLeeegrvel 41
                     sy+  + +++ke++el+ eL+e  r e+
       EFC37076.1  3 SYDHSQLYLKKEIDELEFELKEFDRMEM 30
                     99999****************9888875 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.34
  HU-CCDC81_bac_2 13 isyeeAlqkiekeveelkqeLee 35
                     + +++  ++++ +v++++ +Le+
       EFC37076.1 30 MQFNQKANRLQYQVDSMEAKLEN 52
                     56777789999999999999987 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.022
  HU-CCDC81_bac_2  28 elkqeLeeegrveleniGeLslneegkleFe 58 
                      ++ ++L e  +v+l+ i +L +n +gk++F 
       EFC37076.1 107 DIHDKLREIDSVTLDFIDDLERNLDGKISFF 137
                      678899999********************95 PP

>> TMF_DNA_bd  TATA element modulatory factor 1 DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   1.3    0.0014       1.9      26      71 ..       6      51 ..       3      54 .. 0.90
   2 ?    4.2   0.0     0.031        43      30      63 ..      75     108 ..      72     117 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0014
  TMF_DNA_bd 26 kkelklnntikkLrkknkelekeikelkkkleklekeleeleerlk 71
                +++l l++ i++L  ++ke +    + ++k ++l+ +++++e++l+
  EFC37076.1  6 HSQLYLKKEIDELEFELKEFDRMEMQFNQKANRLQYQVDSMEAKLE 51
                678889999*********************************9997 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.031
  TMF_DNA_bd  30 klnntikkLrkknkelekeikelkkkleklekel 63 
                 k n++i++Lr  +  + + +++lk+ +e l +++
  EFC37076.1  75 KTNEIIDSLRYRLDAQGYHLQNLKESKEYLAMDI 108
                 789********************99888777665 PP

>> FPP  Filament-like plant protein, long coiled-coil
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   2.8   9.1e-05      0.13     690     796 ..       8     116 ..       2     134 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 9.1e-05
         FPP 690 nkllkeeleelksekenlevelksatenleslkaqlqesEqllaelkseLeslkesksla..etqlkcmkesyesletrateleaelnelkqkieaLev 786
                 +  lk+e+ el+ e ++ +    + +++ + l+ q   +E +l++l  ++ +++   s +  e    + +e+  sl  r+      l++lk+  e L +
  EFC37076.1   8 QLYLKKEIDELEFELKEFDRMEMQFNQKANRLQYQVDSMEAKLENLGCDILHVEMVVSHLknEFRYAKTNEIIDSLRYRLDAQGYHLQNLKESKEYLAM 106
                 5678999999999999999999999************************9988876665511556678899**************************** PP

         FPP 787 eLeeekkshe 796
                 +++++ +   
  EFC37076.1 107 DIHDKLREID 116
                 ***9976554 PP

>> RPW8  Arabidopsis broad-spectrum mildew resistance protein RPW8
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   1.4   0.00012      0.17      95     130 ..      10      45 ..       2      54 .. 0.82
   2 ?   -0.2   0.1      0.52   7.1e+02      69      69 ..      84      84 ..      41     130 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00012
        RPW8  95 rYkkklkeLekslrkfvqvelqvqqvrdikellakm 130
                 + kk++ eLe +l++f  +e+q +q +++ ++ +  
  EFC37076.1  10 YLKKEIDELEFELKEFDRMEMQFNQKANRLQYQVDS 45 
                 56899************************9987753 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.52
        RPW8 69 k 69
                +
  EFC37076.1 84 R 84
                2 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   2.9   4.7e-05     0.065      78     126 ..       9      57 ..       3      62 .. 0.90
   2 ?   -0.1   0.1      0.92   1.3e+03      69      84 ..      93     108 ..      60     127 .. 0.53

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.7e-05
      APG6_N  78 eeleaelaaleeelealeeeeerfwreynelqlelleleeeldsleaqy 126
                   l++e+ +le el++ ++ e +f ++ n lq ++ ++e +l+ l + +
  EFC37076.1   9 LYLKKEIDELEFELKEFDRMEMQFNQKANRLQYQVDSMEAKLENLGCDI 57 
                 5689**************************************9998876 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.92
      APG6_N  69 eLkelekereeleael 84 
                  L++l++ +e l+ ++
  EFC37076.1  93 HLQNLKESKEYLAMDI 108
                 3333333333333333 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   1.8    0.0011       1.5       2      44 ..      12      54 ..      11      63 .. 0.90
   2 ?    5.5   0.1     0.019        26       1      54 [.      46     101 ..      46     118 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.0011
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        SlyX  2 eerleeLEiklafqedtieeLndvvaeqqqqidrlqrqlrlla 44
                ++ ++eLE +l   +++  + n+   + q q+d ++++l+ l 
  EFC37076.1 12 KKEIDELEFELKEFDRMEMQFNQKANRLQYQVDSMEAKLENLG 54
                6789**********************************99985 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.019
                 HHHHHHHHHHHHHHHHHHHHHHHHHH..HHHHHHHHHHHHHHHHHHHT-XXXXXXX CS
        SlyX   1 leerleeLEiklafqedtieeLndvv..aeqqqqidrlqrqlrllaerlkeleess 54 
                 +e++le+L + + + e ++  L ++   a+ ++ id l+ +l++   +l++l+es+
  EFC37076.1  46 MEAKLENLGCDILHVEMVVSHLKNEFryAKTNEIIDSLRYRLDAQGYHLQNLKESK 101
                 68899999999999999999998875337788889999999999999999998886 PP

>> LptF_LptG  Lipopolysaccharide export system permease LptF/LptG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.1    0.0018       2.4     214     252 ..      17      71 ..       3     114 .. 0.68
   2 ?    1.5   0.8     0.079   1.1e+02      89     116 ..     134     161 ..     134     169 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0018
   LptF_LptG 214 ekkysretferyridinldpadlsteeespdelslsel.................k 252
                 e +++ ++f+r+++++n++ ++l+ +  s+ e +l +l                 +
  EFC37076.1  17 ELEFELKEFDRMEMQFNQKANRLQYQVDSM-EAKLENLgcdilhvemvvshlkneF 71 
                 44788899***************9999996.4455555444444444443333331 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.079
   LptF_LptG  89 islgrllrpililalllsvlsfllnnyv 116
                 is++r + p ++ ++l+++l  ++  y+
  EFC37076.1 134 ISFFRYYYPTIMRSMLITCLIGFIASYL 161
                 8999999999999999999999999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1415  (0.0789224); expected 358.6 (0.02)
Passed bias filter:                      833  (0.046461); expected 358.6 (0.02)
Passed Vit filter:                       123  (0.00686039); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 1127.32
//
Query:       EFC37077.1  [L=536]
Description: CCT chaperonin gamma subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     1e-167  558.7   7.7   1.1e-167  558.5   7.7    1.0  1  Cpn60_TCP1       TCP-1/cpn60 chaperonin family
     0.0068   16.3   0.0      0.019   14.8   0.0    1.8  1  AbbA_antirepres  Antirepressor AbbA
  ------ inclusion threshold ------
      0.058   13.0   0.4       0.84    9.2   0.0    2.7  3  LepB_N           LepB N-terminal domain


Domain annotation for each model (and alignments):
>> Cpn60_TCP1  TCP-1/cpn60 chaperonin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  558.5   7.7  1.9e-171  1.1e-167       1     488 [.      35     528 ..      35     531 .. 0.97

  Alignments for each domain:
  == domain 1  score: 558.5 bits;  conditional E-value: 1.9e-171
                 HHHHHHCCSSTTXXEEEEEETTSEEEEEXSHHHHHHCSXXXSHHHHHHHHHHHHCCCCCTTCHHHHHHHHHHHHHHHHHHHHCTXXHHHHHHHHHHHHH CS
  Cpn60_TCP1   1 ladivkttlGPkGmdKmlvnkggkvvvTnDGatilkeleiehPaakllveaaesqdeevGDGTttvviLageLleeaekliaagvhpttiiegyekale 99 
                 +a+iv+ttlGPk m+Km+ +++g+v++T+DG++il+e +++hPaak+++e++++qdeevGDGTt+v+iLage+l+ ae l+++++hpt+i++g+ kale
  EFC37077.1  35 IASIVRTTLGPKAMLKMILDQMGTVQLTSDGNAILRECDVTHPAAKSMIELSRTQDEEVGDGTTSVIILAGEILTVAEPLLQRKIHPTRIVKGFLKALE 133
                 799************************************************************************************************ PP

                 HHHHHH.HHHXEEBXSCSTT.HHHHHHHHHHCTTSSXXSTHHHHHHHHHHHHHCHCCCS....EECSCCC.EECCCCEECECTTSEEESEEEESS--SS CS
  Cpn60_TCP1 100 kaleaL.keiaveisseekdreeLlkvartslsskltskeaeelsklvvdAvklieene....keldlgr.ikvvkieggsledselveGlvldkgvls 192
                 +a++++ ++++++i+++  + ee++++++ts+++k+t++ ++ ++kl+++Avk++ ++     k++d++r  +++ki gg l++s++++G++++k++l+
  EFC37077.1 134 DAVDFIsEKMSRKIDVN--NYEEVAEIVNTSIGTKFTHRYSDLMCKLAIQAVKTVATDMengkKDIDVKRyARIEKIPGGLLNESRVLNGVMINKDILH 230
                 ******77776666665..89*******************************666655569*********9**************************** PP

                 TTSSCEEECEEEEEESS-BS--HHCCHHHCCCCSCCHHHHHHHHHHHHHHHHHHHHHHTTECEEEESS-B-HHHHHHHHHCT-EEE-S--HHHHHHHHH CS
  Cpn60_TCP1 193 pdmpkklenakvllldvsLeiektetkttvvlsdaeeleklekaeekqleellekiiksgvnvvvcqkgiddlalhflakngilalrrvkkkdlerlak 291
                 p+m +++en++vllld++Le++k e++t+vvl+++e++e l+k e + ++++++ iik + ++vv++kg +dla+ +l kn+i +lrrv+k+d +r+a+
  EFC37077.1 231 PKMRRRIENPRVLLLDCPLEYKKGESETNVVLEKEEDFETLLKMEDEWIKRVCDDIIKFKPDLVVTEKGCSDLAQYYLIKNNISCLRRVRKTDNNRIAR 329
                 *************************************************************************************************** PP

                 HHT--EBSCGGGGGCGC-EEEEEE.EECCETTCCEEEEECESSSSXEEEEEEESTCCCHHHHHHHHHHHHHHHHHHHHHHEEEETTTCHHHHHHHHHHC CS
  Cpn60_TCP1 292 atGatavssledltpeelGtakkv.eeekigsekttiieevksgkiatillrgatdtvldeieraiedAlnvvknaiedekvvpGGGatelelakklke 389
                 atGat+vs+ ++++++++G+   + e++kig+e++ +iee+k++k++tillrg ++++l+eier++edAl+vvkn++ d++vvpGGGa+e++++++l +
  EFC37077.1 330 ATGATIVSRTSEIKESDIGNGAGLfEVRKIGDEYFSFIEECKDPKACTILLRGGSKDILNEIERNLEDALHVVKNIFVDPRVVPGGGAVEMSVSQHLMQ 428
                 ********************88888************************************************************************** PP

                 CCCTSXCCHHHHHHHHHHHHTHHHHHHHHHCTSXHHHHHHHHHHHH.HTTXTTEEEETTTTCEEECCCCTXEEEHHHHHHHHHHHHHHHHHHHCEEEEE CS
  Cpn60_TCP1 390 yaksvsgeeqlaieafakALevipktLaeNaGldpievlaklraah.nkgekelgidvesgeiidlveagvvDplkvkrqalksAteaastiLrideii 487
                 ++ks++g eql ++a+a ALevip+tL+eN+G+++i ++++lr++h n ++ +lg+d  +g i d  e ++++p++vk q +k+A e+ ++iLrid+++
  EFC37077.1 429 KSKSIKGIEQLPYQAVATALEVIPRTLIENCGANTIRIITELRSKHaNDQNLNLGVDGVKGVIADTAELKIWEPYEVKVQTMKTAIESSCLILRIDDVL 527
                 **********************************************4445589********************************************98 PP

                 X CS
  Cpn60_TCP1 488 k 488
                 +
  EFC37077.1 528 S 528
                 6 PP

>> AbbA_antirepres  Antirepressor AbbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   3.2e-06     0.019      27      54 ..     179     206 ..     173     215 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 3.2e-06
                      HHHHHHHHHHHHHTT----SCHHHHHHH CS
  AbbA_antirepres  27 AlellssElaDIEnGtKkvDekrYkkll 54 
                      A++ +++  +D+EnG+K++D+krY ++ 
       EFC37077.1 179 AIQAVKTVATDMENGKKDIDVKRYARIE 206
                      6777778889**************9885 PP

>> LepB_N  LepB N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1      0.21   1.3e+03      97     127 ..     126     163 ..     119     208 .. 0.55
   2 ?    9.2   0.0   0.00014      0.84      67     151 ..     225     311 ..     219     343 .. 0.90
   3 ?   -0.1   0.0       0.1     6e+02     105     141 ..     428     462 ..     386     494 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.21
      LepB_N  97 kglfpaiaekakklkeklde.......kllkdivskal 127
                 kg+++a+ +++  ++ek+++       +++++iv++++
  EFC37077.1 126 KGFLKALEDAVDFISEKMSRkidvnnyEEVAEIVNTSI 163
                 55555555555555555555555555544444444432 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00014
      LepB_N  67 nedilspleyqGlfnlkkftkgYilnykkikglfpaiaekakklke..kldekllkdivskalkkipadlldketkkelakylgids 151
                 n+dil+p   + + n++ +  +  l+ykk +   + ++ek +++++  k++++ +k + + ++k  p  ++ ++  ++la+y  i++
  EFC37077.1 225 NKDILHPKMRRRIENPRVLLLDCPLEYKKGESETNVVLEKEEDFETllKMEDEWIKRVCDDIIKFKPDLVVTEKGCSDLAQYYLIKN 311
                 89***************************999999999999999874467789999999999999999999***********99975 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.1
      LepB_N 105 ekakklkekldekllkdivskalkkipadlldketkk 141
                 +k+k++k  + e+l  + v +al+ ip  l+++   +
  EFC37077.1 428 QKSKSIKG-I-EQLPYQAVATALEVIPRTLIENCGAN 462
                 44444443.2.356678999*********99886555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (536 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       749  (0.0417759); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2934.37
//
Query:       EFC37078.1  [L=186]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       421  (0.0234815); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 1224.13
//
Query:       EFC37079.1  [L=267]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.9e-19   68.5   2.0    2.8e-17   62.7   2.0    2.1  1  DLIC            Dynein light intermediate chain (DLIC)
     0.0082   16.4   0.5      0.039   14.2   0.5    2.1  1  Roc             Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.082   12.6   0.4        1.6    8.4   0.0    2.7  3  PduV-EutP       Ethanolamine utilisation - propanediol utilis
       0.16   12.0   3.8       0.58   10.2   0.5    2.3  2  Cauli_DNA-bind  Caulimovirus DNA-binding protein


Domain annotation for each model (and alignments):
>> DLIC  Dynein light intermediate chain (DLIC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.7   2.0   6.2e-21   2.8e-17       2     236 ..      27     258 ..      26     266 .. 0.75

  Alignments for each domain:
  == domain 1  score: 62.7 bits;  conditional E-value: 6.2e-21
        DLIC   2 egqnlwsailse..vstrsssklPsgksvlvlGedgsGkttliaklqGve....eekkGrGleylyldvkd....edrddltr......lnvwildGdl 84 
                 e++n+w ++l +  ++ + +  +  + s++ lG+   G+ +l+ ++qG e     ++    +ey y++  d    +d  d tr      ln++ ++ + 
  EFC37079.1  27 ERNNVWGSLLKQqkIDPKLQEGIEDSYSIVFLGDAKNGQRSLVRRFQGKEiagdVYHDTLSIEYTYFKAIDstkhDDFSDSTRndrdkyLNIYQME-NQ 124
                 7899*****986225556677788899*********************9844323677889*****986552111555667773333233444444.67 PP

        DLIC  85 yhkgllkfaleaeslkdtlvilvvdlsrPwtileslqkwasvlrehidklkiepeekreleqrlvkefqeyvepeedlpgsPqrrtprlssvdedsvll 183
                 y   ll fa++ +++++t+v+++vd+s+   i+ + +kw+++l++hid+ ki pe k+e  qr   + ++             +++++++s  e+    
  EFC37079.1 125 YFSYLLDFAINPTTFEKTVVVITVDISNTKNIISRTKKWIRILQDHIDE-KIIPELKEEGMQRCYDRVKSTF-----------KKGEQSTS--EN---- 205
                 999*********************************************9.6778888887777654444333...........33333322..33.... PP

        DLIC 184 PlgedvlttnlGldvvvvvtkcdaisvlekehdyrdehldfiqshirrfclqy 236
                 P    v+ tnlG+++v+ +tk+d+   +   +  +   ++ i +h  +f l  
  EFC37079.1 206 PNEFTVIDTNLGIPIVLAITKSDMAEKIADSFCTKKSIINIIPHHFLNFILFK 258
                 555678999**************999999888888888888888877777654 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.5   8.7e-06     0.039       2     109 ..      55     174 ..      54     178 .. 0.64

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 8.7e-06
                 EEEESSTTSSHHHHHHCHCT-CCC.-EEETTTTEEEEE.EECGGSGGCT...TBTTTTCEEEEEEEE-SGGCTT....TT-HHHHCTSCEEEEEEE.GH CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfs.ekekstigvdflt.kevtkikgve...ndkkvkkvklniWDtaGqerfr....slhplylreaalailvyd.sr 90 
                 +v++Gd++ G  sl++rf+ +++  + ++ t++++++  k + ++k+ +   ++++ ++  lni+ +  q   +    +++p  +++  ++++ +d s+
  EFC37079.1  55 IVFLGDAKNGQRSLVRRFQGKEIAgDVYHDTLSIEYTYfKAIDSTKHDDfsdSTRNDRDKYLNIYQMENQYFSYlldfAINPTTFEK-TVVVITVDiSN 152
                 89******************9997355999999999763444444432211133344557899999998866552322344444444.45555555344 PP

                 HH...HCHHHHHHHHHHHCSSS CS
         Roc  91 ss...enlkeWlkelkkvagks 109
                 ++   ++ k+W++ l+++ +++
  EFC37079.1 153 TKniiSRTKKWIRILQDHIDEK 174
                 4323357799999999887765 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.0   0.00037       1.6       3      42 ..      54      97 ..      52     102 .. 0.84
   2 ?    0.9   0.0     0.075   3.4e+02      56      82 ..     133     159 ..     116     190 .. 0.73
   3 ?   -1.0   0.1       0.3   1.3e+03      90     107 ..     218     235 ..     199     247 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00037
   PduV-EutP  3 killiGkvgsGKttLtqalkgeelk...Ykktqaiefsd.eviD 42
                 i+++G  + G+ +L ++++g+e+    Y+ t +ie++  ++iD
  EFC37079.1 54 SIVFLGDAKNGQRSLVRRFQGKEIAgdvYHDTLSIEYTYfKAID 97
                589*********************5555*******985426677 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.075
   PduV-EutP  56 alivtsaeadvialvqdateeesvfpp 82 
                 a++ t++e  v+++ +d+++++++++ 
  EFC37079.1 133 AINPTTFEKTVVVITVDISNTKNIISR 159
                 455566666666666666666666654 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.3
   PduV-EutP  90 keviGiitkidlaedeen 107
                  +++  itk d+ae+ ++
  EFC37079.1 218 IPIVLAITKSDMAEKIAD 235
                 467777899999876554 PP

>> Cauli_DNA-bind  Caulimovirus DNA-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.5   0.00013      0.58      37      93 ..     137     195 ..     120     212 .. 0.83
   2 ?    2.6   0.2     0.031   1.4e+02      42      66 ..     221     246 ..     211     253 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00013
                     HHHHHHHHHHHHHHHHHHHT-TTHHHHHHHHTXXXXXXXXXXXXXX..XXXXXXXXXXX CS
  Cauli_DNA-bind  37 esleevaakiikdltkkidececnkeiveildkkqdkqiipskked..qkrlslvkysy 93 
                     +++e+    i  d+++  +    +k+ + il+ + d++iip+ ke+  q+  + vk ++
      EFC37079.1 137 TTFEKTVVVITVDISNTKNIISRTKKWIRILQDHIDEKIIPELKEEgmQRCYDRVKSTF 195
                     677888889999****9999**********************99996666667777666 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.031
                     HHHHHHHHHHHHHHT-TTHHH.HHHH CS
  Cauli_DNA-bind  42 vaakiikdltkkidececnke.ivei 66 
                     v a   +d+++ki +  c+k+ i++i
      EFC37079.1 221 VLAITKSDMAEKIADSFCTKKsIINI 246
                     5555668***********98735555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       986  (0.0549947); expected 358.6 (0.02)
Passed bias filter:                      533  (0.0297284); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 1628.79
//
Query:       EFC37080.1  [L=149]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.1e-14   51.0   0.2    1.2e-13   50.6   0.2    1.2  1  Ribosomal_L7Ae  Ribosomal protein L7Ae/L30e/S12e/Gadd45 famil
  ------ inclusion threshold ------
      0.057   13.3   0.0      0.085   12.8   0.0    1.3  1  DUF577          Family of unknown function (DUF577)
      0.071   13.1   0.0      0.099   12.6   0.0    1.2  1  DNA_photolyase  DNA photolyase
      0.091   13.1   0.0       0.16   12.2   0.0    1.4  1  Ribosomal_S6    Ribosomal protein S6


Domain annotation for each model (and alignments):
>> Ribosomal_L7Ae  Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.6   0.2   2.6e-17   1.2e-13       6      88 ..      45     127 ..      36     135 .. 0.85

  Alignments for each domain:
  == domain 1  score: 50.6 bits;  conditional E-value: 2.6e-17
                     HHHHHHHHTEEEESHHHHHHHHHTTTESEEEEETTSSSGGHHHHHHHHHH.HTTEEEEEESCHHHHHHHTTSSSECSEEEEEES CS
  Ribosomal_L7Ae   6 vlkkakkagklvlGlkevtkalergeaklvilAedvepeekkkllealck.ekevpyvkvkskkeLGelvgkkrpvsalaikde 88 
                     ++ ++k+++ l +G+k v +a++++++ +v+lA d  p ++ ++ + l k   +v yv+v+sk eLG++   krp++a+++ ++
      EFC37080.1  45 AV-QSKEKNVLHRGIKNVNRAIRKQTKGFVVLAGDSYPMDIIAHFPELIKsTEGVEYVFVESKVELGKATLTKRPACAIMVAEP 127
                     23.3667777****************************************999**********************777776654 PP

>> DUF577  Family of unknown function (DUF577)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   1.9e-05     0.085     130     169 ..      33      71 ..      18      74 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.9e-05
      DUF577 130 ellekivksvkelVerkmeeelvrrglrdlekivkkdlel 169
                 + ++ki k +++ V + +e++++ rg++++++ ++k+ + 
  EFC37080.1  33 KDVSKIFKVISKAV-QSKEKNVLHRGIKNVNRAIRKQTKG 71 
                 557899********.999*******************986 PP

>> DNA_photolyase  DNA photolyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   2.2e-05     0.099      43     100 ..      46     109 ..      26     121 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.2e-05
                     -CHHHHHHHHHHHHHHHHHHHHTT--EEEEESS.....HHHHHHHHHHHCT.ECEEEEE---SH CS
  DNA_photolyase  43 vgaarvdfllesLadLdeeLrelgirLvvrrgd.....padvlpelakelg.asavvanreyep 100
                     v+++  + l++++++ ++++r++   +vv+ gd     + + +pel+k+++ ++ v+++ ++e 
      EFC37080.1  46 VQSKEKNVLHRGIKNVNRAIRKQTKGFVVLAGDsypmdIIAHFPELIKSTEgVEYVFVESKVEL 109
                     56778889*************************9*66666667799999988999999998875 PP

>> Ribosomal_S6  Ribosomal protein S6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   3.6e-05      0.16      13      83 ..      31      98 ..      24     103 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 3.6e-05
                  -HHHHHHHHHHHHHHHHHTTEEEEEEEEEEEEEEEEEETTEEEEEEEEEEEEESCCHHHHHHHHHHCSTTE CS
  Ribosomal_S6 13 seeevkelvekvgklilenggvvrkveswGkrkLaypikkkteGyyvlmnfdaspevikelertlrlderv 83
                  se++v+++ + ++k+++++    ++v + G ++  + i+k+t+G+ vl   + + ++i+ + + ++ +e v
    EFC37080.1 31 SEKDVSKIFKVISKAVQSK---EKNVLHRGIKNVNRAIRKQTKGFVVLAGDSYPMDIIAHFPELIKSTEGV 98
                  5678899999999999887...677889*******************998888888888888877777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      458  (0.0255452); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 999.19
//
Query:       EFC37081.1  [L=166]
Description: hypothetical protein NAEGRDRAFT_82024 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       973  (0.0542696); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1099.49
//
Query:       EFC37082.1  [L=1702]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      1e-13   51.3   2.4    1.1e-12   47.9   0.2    2.5  2  NARG2_C       NMDA receptor-regulated gene protein 2 C-termin
     0.0013   18.6   6.0     0.0019   18.1   0.3    3.3  3  eIF-5_eIF-2B  Domain found in IF2B/IF5
  ------ inclusion threshold ------
      0.032   14.3   0.0       0.11   12.6   0.0    1.8  1  NUDIX         NUDIX domain
      0.056   13.5   1.9        3.5    7.7   0.2    3.2  2  CpXC          CpXC protein
       0.07   13.3   4.1      0.046   13.9   0.6    2.7  3  SAM_KSR1      SAM like domain present in kinase suppressor RA


Domain annotation for each model (and alignments):
>> NARG2_C  NMDA receptor-regulated gene protein 2 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.9   0.2   3.1e-16   1.1e-12      11     107 ..     796     889 ..     774     918 .. 0.85
   2 ?    2.7   0.1     0.022        78     124     196 ..     939    1022 ..     925    1034 .. 0.72

  Alignments for each domain:
  == domain 1  score: 47.9 bits;  conditional E-value: 3.1e-16
     NARG2_C  11 vvyklwsLkaeesellllvrlsvdavetlkkk.kklpvhllpKlEyqpeyGvEaltksEllelWlellLrsntvllvvridaqtskllllekltlesl 107
                 ++y+l++L     +l+ll+r+++d+++   k+ +++ + l++KlEyq+e G E  t+sEl + W    +r+++  +++r+d+ ++++   e   ++++
  EFC37082.1 796 ITYNLFTLA----NLKLLIRTKLDGANMDVKTdRPTAIKLMTKLEYQTEKGLELSTQSELAKWWSVVFMRPASAAVLTRVDVAQNRVCRTEFKRIKDI 889
                 678999999....***********99876665599************************************************999988776665554 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.022
     NARG2_C  124 siLheiLkkls..slqeGeYLLrhkakdsfvtiykss.........skkatrssfdLhellssletepsslevpwvpidpslvl 196 
                  + + +++ +++  +l++ ++L+++ +++s+v ++ +          +  +++  +dLh+ + +  + + ++ +p++p+  ++  
  EFC37082.1  939 TEVTKLITLFQkfNLKDYRFLIQKMPNESLVHLLVEYrkstpdhipRGLPQKFYYDLHSDYEKHGAITETQIMPYIPLMWKING 1022
                  44445555554115677889999999999777754444448888887788999**********988888888*****9766554 PP

>> eIF-5_eIF-2B  Domain found in IF2B/IF5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.56     2e+03      37      64 ..    1272    1299 ..    1266    1322 .. 0.73
   2 !   18.1   0.3   5.2e-07    0.0019      64      99 ..    1336    1372 ..    1321    1388 .. 0.77
   3 ?    1.2   0.3     0.093   3.3e+02      69      97 ..    1399    1427 ..    1386    1436 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.56
                    HHTTSHHHHHHHHHHHHTSEEEESETTE CS
  eIF-5_eIF-2B   37 aLnrdpehvlkyllkelgtqgsidengr 64  
                     ++r+++ ++ky++++   +  +d n++
    EFC37082.1 1272 FVDRKKKDLMKYIGFKTEKTCFFDVNDE 1299
                    57899********999888888875544 PP

  == domain 2  score: 18.1 bits;  conditional E-value: 5.2e-07
                    EEEESSSSS.CCHHHHHHHHHHHHHTSTSSSTSTCEE CS
  eIF-5_eIF-2B   64 rlilngkfe.akkleklldkyieeyVlCkeCkspete 99  
                    ++ +n + + +k ++++l++yi++y +C++Cks  t+
    EFC37082.1 1336 TISMNEENQmSKLIDQVLQSYISNYMVCPSCKSIKTT 1372
                    4555555441567899*****************9986 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.093
                    SSSSCCHHHHHHHHHHHHHTSTSSSTSTC CS
  eIF-5_eIF-2B   69 gkfeakkleklldkyieeyVlCkeCkspe 97  
                     ++++++l + ld++    ++C+ C+++e
    EFC37082.1 1399 TEYQEEQLIERLDDFTFFTIQCRDCDHKE 1427
                    578999999******9999******9876 PP

>> NUDIX  NUDIX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0     3e-05      0.11      30      79 ..    1609    1660 ..    1598    1684 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3e-05
                  EESSEEECBTTS.HHHHHHHHHHHHHHSEEE.EEEEEEEEEEEEEEEEEEEE CS
       NUDIX   30 WelPgGkvepgE.tpeeAArREleEEtGlea.ellellgrlhylapydgpyg 79  
                  W+  gGk e+ + + +e+A+RE+ EEt     +  + l+  +  ++++g+y 
  EFC37082.1 1609 WSEFGGKREKADtNSAETAAREFYEETKAAFgNIYDKLSTSEGYYFENGKYN 1660
                  8889********9999***********9622222244444444444444443 PP

>> CpXC  CpXC protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.2     0.012        42      24      73 ..    1346    1396 ..    1336    1407 .. 0.67
   2 ?    7.7   0.2   0.00099       3.5      22      51 ..    1402    1431 ..    1395    1471 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.012
        CpXC   24 pelkeklldgslfe.atCpkCgatakleapllyhdpekellillvpesers 73  
                  ++l +++l+  + + ++Cp+C    + +  ++ hd+++++l  +  +++ +
  EFC37082.1 1346 SKLIDQVLQSYISNyMVCPSCKSIKTTNPIVVDHDQQQRILQEFKDDNNVD 1396
                  45666777766654168****988888777777887777776666655544 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00099
        CpXC   22 edpelkeklldgslfeatCpkCgataklea 51  
                  ++++l e+l d ++f+++C +C+++ +++ 
  EFC37082.1 1402 QEEQLIERLDDFTFFTIQCRDCDHKERIDN 1431
                  5788999*****************998875 PP

>> SAM_KSR1  SAM like domain present in kinase suppressor RAS 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0       4.5   1.6e+04      90     117 ..      38      65 ..      31      68 .. 0.78
   2 ?   -3.4   0.1       2.8     1e+04      36      46 ..     132     142 ..     131     180 .. 0.67
   3 ?   13.9   0.6   1.3e-05     0.046      56     125 ..     838     907 ..     827     912 .. 0.88

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 4.5
    SAM_KSR1  90 klsleelLkmseeelkqllsevqaeeee 117
                 +++l + L++ +e ++  ++  +++++e
  EFC37082.1  38 LSPLPANLEIPSESIRRTINGFNSNSNE 65 
                 56788999999*****999996666544 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.8
    SAM_KSR1  36 LEsKlvkyfSe 46 
                 +EsKl+k fS 
  EFC37082.1 132 MESKLLKHFSI 142
                 68888888884 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 1.3e-05
    SAM_KSR1  56 ereranelqkypelkqWLrvvglsqetleailnkklsleelLkmseeelkqllsevqaeeeelrRllaAm 125
                 ++e+  el +  el +W  vv ++++++ +++   ++ + + + + + +k++l +++ eeee  R  + m
  EFC37082.1 838 QTEKGLELSTQSELAKWWSVVFMRPASAAVLTRVDVAQNRVCRTEFKRIKDILPSNEDEEEENERYWSNM 907
                 45667899999****************************************************9987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1702 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3239  (0.180657); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                       269  (0.0150036); expected 17.9 (0.001)
Passed Fwd filter:                        98  (0.005466); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 2.58u 0.39s 00:00:02.97 Elapsed: 00:00:00.70
# Mc/sec: 7332.94
//
Query:       EFC37083.1  [L=488]
Description: hypothetical protein NAEGRDRAFT_82028 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-27   96.7   0.3    2.7e-27   95.5   0.3    1.6  1  bVLRF1          bacteroidetes VLRF1 release factor
  ------ inclusion threshold ------
      0.018   14.9   0.0      0.039   13.8   0.0    1.5  1  F-box-like      F-box-like
       0.15   12.1   0.0       0.24   11.4   0.0    1.3  1  Glyco_transf_4  Glycosyltransferase Family 4


Domain annotation for each model (and alignments):
>> bVLRF1  bacteroidetes VLRF1 release factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.5   0.3   4.5e-31   2.7e-27       2     110 ..     251     364 ..     250     375 .. 0.89

  Alignments for each domain:
  == domain 1  score: 95.5 bits;  conditional E-value: 4.5e-31
      bVLRF1   2 vllmlggGhfAgavvslkkkk.....eaevlahktfhrYttRrkqGgsQsandkakgkaksaGaslRryneqalkedirellkewkeeiekse.lifir 94 
                  +++++gG f+g+v++ + +k      +  + hktfh+Y+tR+kqG++Q ++d++k  aks+G+++Rr +e+++k + r+ l+ w++ ++k +  if++
  EFC37083.1 251 CVIFCHGGSFSGCVFQKNGRKqknaePMVATVHKTFHKYVTRKKQGKRQVSKDQSKR-AKSVGSQIRRMQEEHFKLKTRKYLTMWSDSLSKRDtIIFLN 348
                 5899************7766678776666789*********************8887.*****************************9988762579** PP

      bVLRF1  95 asgksnrkilfgyeea 110
                 a+g +n+ +lf+++++
  EFC37083.1 349 APGPYNEYTLFNKKKE 364
                 ***********97764 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   6.6e-06     0.039      19      42 ..     104     127 ..      67     130 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 6.6e-06
  F-box-like  19 sdLlrlalVCrrWrrvaldtplLW 42 
                 ++Ll+l lV ++W+++++ + +L+
  EFC37083.1 104 EELLSLILVNKQWYELVSAHHQLY 127
                 47***************9999999 PP

>> Glyco_transf_4  Glycosyltransferase Family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0     4e-05      0.24      57     122 ..     234     300 ..     207     331 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4e-05
  Glyco_transf_4  57 slaflrrlrrllkrekpDvvHahspaalgaallalrr..rlgiplVltvHglyekrllkarlkplsrl 122
                        flr+l++++ + ++ v+ +h+  + g++  +  r  +   p+V+tvH +++ +++ ++++ ++++
      EFC37083.1 234 FQFFLRDLKNHFLEKGFCVIFCHGGSFSGCVFQKNGRkqKNAEPMVATVHKTFH-KYVTRKKQGKRQV 300
                     335678899999999*****99998777777776666799999**********6.3333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1857  (0.103575); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 3060.68
//
Query:       EFC37084.1  [L=246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-32  112.5   0.0    2.9e-32  112.1   0.0    1.2  1  NmrA            NmrA-like family
    0.00011   22.2   0.0    0.00019   21.4   0.0    1.4  1  NAD_binding_10  NAD(P)H-binding


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  112.1   0.0   3.2e-36   2.9e-32      53     231 ..       2     183 ..       1     185 [. 0.94

  Alignments for each domain:
  == domain 1  score: 112.1 bits;  conditional E-value: 3.2e-36
                 T-HHHHHHHHTT-SEEEE---GG.......S-HHHHHHHHHHHHHHHS-SEEEEEE---GG.GT.SSS---TTTHHHHHHHHHHHHCTS-E.EEEEE-E CS
        NmrA  53 ddkeslvealkgvdvvfsvtgfy.......skeiedgkklvdAakeaGvkhfiySslgddndrsnaeepavphfdsKaeieeyvralgipy.tfvyagf 143
                  dk+ l+ea+kg+++vf  t+         +ke+++g +lv+Aa++  v+hf++Ssl d  ++s +++ +vphf +K ++e+  r+  ip+ tfvy++f
  EFC37084.1   2 SDKNGLEEAFKGAYGVFGLTTPGgfgstdhEKELHEGLNLVEAAVKNNVQHFVFSSLDDVTKASGGKI-SVPHFTNKNKVEQEARKTNIPFkTFVYPPF 99 
                 69999*************9996688999*********************************9998888.*********************65******* PP

                 EGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE.-HHHHHHHHHHHHHHHHHHHTTEEEEE-SEEE-HHHHHHHHHHHHTS-EEE CS
        NmrA 144 fmenflsllaqlkvgdtappedkvtllgpgnpkavll.daeeDiGafvikilkdprklkgkriklagntlsgneivelfekkigktvkY 231
                 f+ n+ +++       +++++ ++ + +  n++ +++ +a++D G +v +++k+p++++g+ i  ag++++++e++++ +++++ + +Y
  EFC37084.1 100 FADNLPGMMFR-----LNEDRASAMIFAGINTDRKIPvFAVDDLGIVVSEVFKNPTTYNGRKILTAGDYVTLKEMADICTQVLNIPTQY 183
                 *******9999.....7888888999999999999999****************************************99998877666 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.0   2.1e-08   0.00019      49     150 ..       2     105 ..       1     123 [. 0.79

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 2.1e-08
                     T-CCHHHHHHTT-SEEEES-...--TCCHHHH....HHHHHHHHHHCT--EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSS CS
  NAD_binding_10  49 tdvedlaealkgadaVvsal...ggggkdeeg....aknivdaakeagvkRfvlvsaigvgdevpgefgewnkellkaylaakraaeellrasgl 136
                     +d++ l+ea+kga  V+  +   g g++d+e       n+v+aa +++v++fv+ s  +v++ + g+ +        + +  k++ e++ r++++
      EFC37084.1   2 SDKNGLEEAFKGAYGVFGLTtpgGFGSTDHEKelheGLNLVEAAVKNNVQHFVFSSLDDVTKASGGKISV-------PHFTNKNKVEQEARKTNI 89 
                     578889**********9888675333334333557899******************99999765555543.......56789************* PP

                     EE.EEEEE-CEE-S.T CS
  NAD_binding_10 137 dw.TivrpggLtde.p 150
                      + T+v p+++ d+ p
      EFC37084.1  90 PFkTFVYPPFFADNlP 105
                     *88*******999834 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.26s 00:00:00.66 Elapsed: 00:00:00.41
# Mc/sec: 1788.40
//
Query:       EFC37085.1  [L=975]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (975 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1380  (0.0769703); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.78u 0.32s 00:00:01.10 Elapsed: 00:00:00.49
# Mc/sec: 5957.34
//
Query:       EFC37086.1  [L=395]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.027   15.1   0.0         21    6.0   0.0    3.0  2  LRR_2     Leucine Rich Repeat
       0.33   11.5   0.1       0.33   11.5   0.1    4.0  4  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0    0.0026        23       3      26 .]     272     295 ..     270     295 .. 0.83
   2 ?    6.0   0.0    0.0023        21       1      14 [.     296     309 ..     296     312 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0026
       LRR_2   3 KtLhLdsVrfsdedslekLLSgCP 26 
                  tL L++V+  d ++++++L  +P
  EFC37086.1 272 HTLQLSCVKNIDNETMNRFLGHFP 295
                 79*******955559****98887 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0023
       LRR_2   1 sLKtLhLdsVrfsd 14 
                 +LK+L+++++ f++
  EFC37086.1 296 NLKSLYISTCQFTN 309
                 6***********98 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.24   2.2e+03      25      33 ..     223     231 ..     210     240 .. 0.65
   2 ?   11.5   0.1   3.6e-05      0.33       2      35 ..     270     306 ..     269     313 .. 0.77
   3 ?    0.4   0.0      0.11   9.7e+02      14      32 ..     332     349 ..     326     359 .. 0.69
   4 ?    0.7   0.3      0.09   8.1e+02       2      14 ..     379     392 ..     372     395 .] 0.68

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.24
                 --EEE-.-S CS
       LRR_4  25 LkeLdLsgN 33 
                 L++L L +N
  EFC37086.1 223 LTSLKLINN 231
                 555555444 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 3.6e-05
                 S--EEE--SS---E-S-......HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl......leklpnLkeLdLsgNnl 35 
                 n  +L Ls   ++ i++      l+ +pnLk+L++s + +
  EFC37086.1 270 NVHTLQLSC--VKNIDNetmnrfLGHFPNLKSLYISTC-Q 306
                 667899997..888888666664556*********988.3 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.11
                 -E-S-HHH-TT--EEE-.- CS
       LRR_4  14 tdiplleklpnLkeLdLsg 32 
                 t +++++ l  L++L + +
  EFC37086.1 332 TGLSSPY-LEELTVLCIES 349
                 4566677.99999997744 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.09
                 S--EEE--.SS--- CS
       LRR_4   2 nLevLdLs.nNqlt 14 
                 +Le+L+ s +Nql+
  EFC37086.1 379 KLESLCVSrQNQLS 392
                 56666666656654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (395 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       656  (0.0365888); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2408.31
//
Query:       EFC37087.1  [L=999]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.2   10.5   0.0       0.33    9.8   0.0    1.2  1  DUF1173   Protein of unknown function (DUF1173)
          5    6.7  12.7         12    5.4  12.7    1.6  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> DUF1173  Protein of unknown function (DUF1173)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   3.7e-05      0.33      41      94 ..     476     528 ..     458     531 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 3.7e-05
     DUF1173  41 yvarvedkyllkrmPetGkeHapdCdsyevpeelsglgevigsavvedeedGet 94 
                    +++  +  +r P tG++ +pdC++ e  ++l+++g  +g+ vv +  dG+ 
  EFC37087.1 476 SYNQNNVAFFSARGPATGNRMKPDCKFIE-IYQLTQKGVAVGDRVVSTRSDGSL 528
                 455666789999****************9.99****************999985 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4  12.7    0.0014        12      53      96 ..     906     949 ..     882     984 .. 0.42

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0014
       SR-25  53 kekkkkkrrrssssssssssssssssssssssssddrkkrgkkk 96 
                 ++ ++  + +++ss s+ +ss ssssss+   ss++++  g + 
  EFC37087.1 906 QQPAQASSASQASSNSTNASSGSSSSSSTPTPSSNSNNAAGASS 949
                 22222222222222222222222222222222222211111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (999 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1640  (0.0914719); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.88u 0.30s 00:00:01.18 Elapsed: 00:00:00.49
# Mc/sec: 6108.75
//
Query:       EFC37088.1  [L=531]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-28   96.0  62.4    6.3e-05   22.7   0.1   16.5 17  LRR_6     Leucine Rich repeat
    1.5e-14   53.9  86.6    0.00088   19.6   0.3   11.7 12  LRR_4     Leucine Rich repeats (2 copies)
    1.5e-12   47.1  66.5      0.019   14.7   2.6    9.6  9  LRR_8     Leucine rich repeat
      2e-05   24.5  51.7        3.5    8.5   0.2   13.8 16  LRR_1     Leucine Rich Repeat
     0.0067   17.1   0.8         31    5.5   0.0    5.1  4  LRR_2     Leucine Rich Repeat
  ------ inclusion threshold ------
       0.38   10.2  26.5        1.5    8.3   0.5    5.2  6  LRR_9     Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0039        12       3      23 ..      20      40 ..      18      41 .. 0.82
   2 !    9.2   0.0   0.00044       1.3       4      17 ..      46      59 ..      44      66 .. 0.85
   3 !   20.2   0.0   1.3e-07    0.0004       3      24 .]      70      91 ..      68      91 .. 0.91
   4 ?   -1.5   0.0       1.2   3.7e+03      14      24 .]     107     117 ..     105     117 .. 0.79
   5 !   10.7   0.3   0.00015      0.44       5      22 ..     124     141 ..     121     143 .. 0.87
   6 ?    3.7   0.1     0.027        80       3      12 ..     146     155 ..     145     167 .. 0.87
   7 ?    1.4   0.5      0.15   4.4e+02       4      24 .]     173     193 ..     170     193 .. 0.91
   8 !   12.2   0.0   5.1e-05      0.15       2      24 .]     197     219 ..     196     219 .. 0.93
   9 !   10.1   0.9   0.00023       0.7       2      23 ..     223     244 ..     223     245 .. 0.91
  10 !    7.3   0.9    0.0018       5.4       2      23 ..     294     315 ..     293     316 .. 0.92
  11 !    7.1   0.2    0.0021       6.4       4      17 ..     320     333 ..     319     339 .. 0.88
  12 !    7.3   0.0    0.0019       5.6       2      23 ..     343     364 ..     342     365 .. 0.87
  13 !   22.7   0.1   2.1e-08   6.3e-05       4      24 .]     371     391 ..     368     391 .. 0.92
  14 ?    2.7   0.1     0.056   1.7e+02       3      16 ..     396     409 ..     394     411 .. 0.91
  15 ?    0.3   0.1      0.32   9.7e+02       5      16 ..     423     434 ..     417     435 .. 0.85
  16 !    6.4   0.1    0.0035        10       8      18 ..     451     461 ..     446     461 .. 0.92
  17 ?    1.7   0.0      0.12   3.5e+02       3      14 ..     499     510 ..     499     513 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0039
       LRR_6  3 thLteLdLsgNdIgDeGaeaL 23
                +++  LdL gN+Ig + +e L
  EFC37088.1 20 SNIHRLDLEGNKIGRKSIELL 40
                67899********97777766 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00044
       LRR_6  4 hLteLdLsgNdIgD 17
                +L+eL++s+N I+ 
  EFC37088.1 46 NLKELNISSNRIDS 59
                7***********86 PP

  == domain 3  score: 20.2 bits;  conditional E-value: 1.3e-07
       LRR_6  3 thLteLdLsgNdIgDeGaeaLa 24
                + L+ L++s+N Ig+eG+e L+
  EFC37088.1 70 RFLRILNVSHNSIGNEGLEYLM 91
                679***************9885 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 1.2
       LRR_6  14 dIgDeGaeaLa 24 
                 +I+DeG +++a
  EFC37088.1 107 KINDEGTMCFA 117
                 49****88776 PP

  == domain 5  score: 10.7 bits;  conditional E-value: 0.00015
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 L +L+L gN+I+ eG++ 
  EFC37088.1 124 LAHLNLGGNNISVEGCKN 141
                 789************986 PP

  == domain 6  score: 3.7 bits;  conditional E-value: 0.027
       LRR_6   3 thLteLdLsg 12 
                 ++Lt+L+Ls+
  EFC37088.1 146 SSLTSLNLSD 155
                 79******97 PP

  == domain 7  score: 1.4 bits;  conditional E-value: 0.15
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L +   +++D  +e+L+
  EFC37088.1 173 NLTKLRVDNSNLNDGAIECLC 193
                 8**************999998 PP

  == domain 8  score: 12.2 bits;  conditional E-value: 5.1e-05
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                 n +L +Ld++ N++++eGa  +a
  EFC37088.1 197 NFKLSSLDIRINQVTNEGADMIA 219
                 889****************9987 PP

  == domain 9  score: 10.1 bits;  conditional E-value: 0.00023
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                 n hL+ L++++N +   G+ +L
  EFC37088.1 223 NAHLKVLNIAHNSLETLGILSL 244
                 88************99999887 PP

  == domain 10  score: 7.3 bits;  conditional E-value: 0.0018
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                 n++L++L+++  +++ e +e +
  EFC37088.1 294 NNNLKTLHVALSNLTTESIELI 315
                 99***************99987 PP

  == domain 11  score: 7.1 bits;  conditional E-value: 0.0021
       LRR_6   4 hLteLdLsgNdIgD 17 
                  Lt+Ld++ N++ D
  EFC37088.1 320 QLTSLDVANNKLCD 333
                 69*********998 PP

  == domain 12  score: 7.3 bits;  conditional E-value: 0.0019
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  ++Lt L+++gN+++ + +e +
  EFC37088.1 343 LSNLTNLSVAGNELTYQSMEYI 364
                 589************9988876 PP

  == domain 13  score: 22.7 bits;  conditional E-value: 2.1e-08
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L++L++s+N++g eGa+aL+
  EFC37088.1 371 KLKTLNISSNNVGAEGAKALF 391
                 8******************95 PP

  == domain 14  score: 2.7 bits;  conditional E-value: 0.056
       LRR_6   3 thLteLdLsgNdIg 16 
                 t+L  L +++N+Ig
  EFC37088.1 396 TKLHILIMNFNQIG 409
                 799**********8 PP

  == domain 15  score: 0.3 bits;  conditional E-value: 0.32
       LRR_6   5 LteLdLsgNdIg 16 
                 Lt L L++N+Ig
  EFC37088.1 423 LTFLLLRSNQIG 434
                 777889*****8 PP

  == domain 16  score: 6.4 bits;  conditional E-value: 0.0035
       LRR_6   8 LdLsgNdIgDe 18 
                 LdLs NdIg e
  EFC37088.1 451 LDLSNNDIGTE 461
                 9********87 PP

  == domain 17  score: 1.7 bits;  conditional E-value: 0.12
       LRR_6   3 thLteLdLsgNd 14 
                 ++L++L+L+ N 
  EFC37088.1 499 PSLKHLNLQTNP 510
                 58******9886 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   1.0   3.2e-06    0.0095       2      37 ..      21      58 ..      20      60 .. 0.78
   2 !    8.8   0.6   0.00076       2.3       3      33 ..      72     106 ..      71     111 .. 0.78
   3 !   11.5   1.8    0.0001      0.31       3      32 ..     124     155 ..     123     162 .. 0.79
   4 ?    4.1   6.8     0.022        66       2      36 ..     147     184 ..     146     213 .. 0.79
   5 ?   -5.5  19.2         6   1.8e+04       2      33 ..     225     258 ..     224     338 .. 0.84
   6 !   10.5   2.1   0.00022      0.67       1      38 [.     319     355 ..     319     360 .. 0.76
   7 !   13.7   2.6   2.1e-05     0.062       2      34 ..     345     381 ..     344     384 .. 0.83
   8 !    9.8   2.8   0.00036       1.1       2      37 ..     371     409 ..     371     417 .. 0.83
   9 !    7.4   1.1     0.002         6       1      38 [.     396     435 ..     396     439 .. 0.83
  10 !   15.9   1.1   4.5e-06     0.013       2      39 ..     422     458 ..     421     465 .. 0.82
  11 !   19.6   0.3   2.9e-07   0.00088       1      42 [.     446     490 ..     446     492 .. 0.86
  12 !   16.8   1.2   2.3e-06    0.0069       3      35 ..     474     510 ..     472     516 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.2e-06
                S--EEE--SS---..E-S-HH.H-TT--EEE-.-S---- CS
       LRR_4  2 nLevLdLsnNqlt..diplle.klpnLkeLdLsgNnlit 37
                n   LdL +N++   +i+ll+ +l nLkeL++s+N +i+
  EFC37088.1 21 NIHRLDLEGNKIGrkSIELLSaGLVNLKELNISSN-RID 58
                67789***99**95455556657*********999.554 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00076
                 --EEE--SS---E-S-HH.....H-TT--EEE-.-S CS
       LRR_4   3 LevLdLsnNqltdiplle.....klpnLkeLdLsgN 33 
                 L++L+ s+N +    +le     +l  L+ L +++ 
  EFC37088.1  72 LRILNVSHNSIGNE-GLEylmsgNLVELERLECTNV 106
                 99**********55.544467757*********554 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 0.0001
                 --EEE--SS---E-S-HH..H.-TT--EEE-.- CS
       LRR_4   3 LevLdLsnNqltdiplle..k.lpnLkeLdLsg 32 
                 L +L+L++N+++ +++++    l +L++L+Ls+
  EFC37088.1 124 LAHLNLGGNNIS-VEGCKnvAlLSSLTSLNLSD 155
                 779*********.667555766999******76 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.022
                 S--EEE--SS---.E-S-.HH....H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqlt.dipl.le....klpnLkeLdLsgNnli 36 
                 +L++L+Ls+  +  ++    +    kl nL++L + +N+++
  EFC37088.1 147 SLTSLNLSD--IDvSVAAmENickgKLENLTKLRV-DNSNL 184
                 79******9..663333354466666*********.66445 PP

  == domain 5  score: -5.5 bits;  conditional E-value: 6
                 S--EEE--SS---E-S-HH..H-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdiplle..klpnLkeLdLsgN 33 
                 +L+vL++++N l +++ l+   ++n +++++  N
  EFC37088.1 225 HLKVLNIAHNSLETLGILSllFMDNIESINIEKN 258
                 6899999999999999955545999999999666 PP

  == domain 6  score: 10.5 bits;  conditional E-value: 0.00022
                 SS--EEE--SS---E-S-..HH.H-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le.klpnLkeLdLsgNnlitd 38 
                 ++L++Ld +nN+l d +   +  kl nL+ L++ gN     
  EFC37088.1 319 TQLTSLDVANNKLCDTNVktITtKLSNLTNLSVAGN----E 355
                 68********99655555443348*********999....3 PP

  == domain 7  score: 13.7 bits;  conditional E-value: 2.1e-05
                 S--EEE--SS---E-S-...HH.H-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl...le.klpnLkeLdLsgNn 34 
                 nL++L+ ++N lt  +     + +l +Lk+L++s+Nn
  EFC37088.1 345 NLTNLSVAGNELTYQSMeyiSSgSLLKLKTLNISSNN 381
                 9************76667652246*********9995 PP

  == domain 8  score: 9.8 bits;  conditional E-value: 0.00036
                 S--EEE--SS---E-S-....HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl....leklpnLkeLdLsgNnlit 37 
                 +L++L++s+N++   +     l++ ++L+ L +++N +i+
  EFC37088.1 371 KLKTLNISSNNVGAEGAkalfLGNTTKLHILIMNFN-QIG 409
                 79***********87779987778*******99555.883 PP

  == domain 9  score: 7.4 bits;  conditional E-value: 0.002
                 SS--EEE--SS---.E-S-HH..H-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqlt.diplle..klpnLkeLdLsgNnlitd 38 
                 ++L +L  + Nq+   i  l+   l+ L+ L L + n+i++
  EFC37088.1 396 TKLHILIMNFNQIGeGITYLNntTLKGLTFL-LLRSNQIGK 435
                 68999****99*9999999998559999999.767779875 PP

  == domain 10  score: 15.9 bits;  conditional E-value: 4.5e-06
                 S--EEE--SS---.E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqlt.dipl..leklpnLkeLdLsgNnlitdl 39 
                  L++L L++Nq+   + +  ++ lp+L  LdLs+N    d+
  EFC37088.1 422 GLTFLLLRSNQIGkYLKGvsFNALPKLGLLDLSNN----DI 458
                 7**********995555566667*********999....77 PP

  == domain 11  score: 19.6 bits;  conditional E-value: 2.9e-07
                 SS--EEE--SS---E-S-..HH..H-TT--EEE-.-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..klpnLkeLdLsgNnlitdldeL 42 
                 p+L  LdLsnN + + ++  ++  k+p L +L++ g+n it+++ L
  EFC37088.1 446 PKLGLLDLSNNDIGTEEFacFSqqKFPLLSTLNC-GMNAITRVSVL 490
                 67888*********99999844656*********.999***99877 PP

  == domain 12  score: 16.8 bits;  conditional E-value: 2.3e-06
                 --EEE--SS---E-S-HH.....H-TT--EEE-.-S-- CS
       LRR_4   3 LevLdLsnNqltdiplle.....klpnLkeLdLsgNnl 35 
                 L +L+++ N +t ++ l      ++p+Lk+L+L  N +
  EFC37088.1 474 LSTLNCGMNAITRVSVLIetlssNFPSLKHLNLQTN-P 510
                 779****99*******44466666*********555.5 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   4.0   1.1e-05     0.034       2      61 .]      21      82 ..      20      82 .. 0.85
   2 !    9.4   1.7    0.0003      0.89       2      37 ..      46      82 ..      46     101 .. 0.72
   3 !   11.9   0.2   4.7e-05      0.14      24      57 ..     121     154 ..     116     156 .. 0.90
   4 ?    0.9   0.1      0.13   3.8e+02       2      14 ..     173     185 ..     169     196 .. 0.83
   5 !   14.7   2.6   6.2e-06     0.019       2      59 ..     199     258 ..     198     259 .. 0.89
   6 ?    2.1   1.4     0.055   1.6e+02      25      48 ..     286     307 ..     266     316 .. 0.80
   7 !   13.2   7.2   1.9e-05     0.057       2      60 ..     320     381 ..     319     382 .. 0.91
   8 !   13.9   4.5   1.2e-05     0.035       3      61 .]     398     458 ..     396     458 .. 0.79
   9 !    7.9   0.3   0.00087       2.6      14      42 ..     488     516 ..     469     526 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.1e-05
                T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61
                n ++LdL  N++   + e  +  l nLk+L++s+N++++         L+ Lr L++s+N +
  EFC37088.1 21 NIHRLDLEGNKIGRKSIELLSAgLVNLKELNISSNRIDSgACYYLAKELRFLRILNVSHNSI 82
                789999*****999999999888************998865567777888899999999976 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0003
                T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNll 37
                nL++L++s+Nr+ s       + l+ L++L+ s+N++
  EFC37088.1 46 NLKELNISSNRIDSGACYYLAKeLRFLRILNVSHNSI 82
                6778888888866544444433388888888888876 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 4.7e-05
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 + +L +L+L+ N++++   +  + L+sL+sL+Ls
  EFC37088.1 121 CGKLAHLNLGGNNISVEGCKNVALLSSLTSLNLS 154
                 67899***********999*************98 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.13
                 T-SEEE-TTS--S CS
       LRR_8   2 nLtsLdLsnNrlt 14 
                 nLt+L ++n++l+
  EFC37088.1 173 NLTKLRVDNSNLN 185
                 7888888888876 PP

  == domain 5  score: 14.7 bits;  conditional E-value: 6.2e-06
                 T-SEEE-TTS--SEE-TTSSTT..-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg..lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +L+sLd++ N+ t+ + ++  +  + +LkvL++ +N+l+tl   ++  + +++s++++ N
  EFC37088.1 199 KLSSLDIRINQVTNEGADMIAKsmNAHLKVLNIAHNSLETLGILSLLFMDNIESINIEKN 258
                 69999999999888888887776899***************9999999999999999988 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.055
                 TT--EEE--SS---GGGGGGGTT- CS
       LRR_8  25 snLkvLdLsnNllttlspgafsgL 48 
                 + L +L L+nN l+tl+  a+s+L
  EFC37088.1 286 NDLISLVLNNN-LKTLH-VALSNL 307
                 56889999888.88887.777776 PP

  == domain 7  score: 13.2 bits;  conditional E-value: 1.9e-05
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G..GGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsgNr 60 
                 +LtsLd+ nN+l + + ++ ++ lsnL+ L+   N+lt   ++  +  +L +L+ L++s+N+
  EFC37088.1 320 QLTSLDVANNKLCDTNVKTITTkLSNLTNLSVAGNELTYqsMEYISSGSLLKLKTLNISSNN 381
                 8*******************999************9987557778888999**********8 PP

  == domain 8  score: 13.9 bits;  conditional E-value: 1.2e-05
                 -SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 L++L+ ++N+  +++     ++l++L+ L L++N++   l   +f  Lp+L  LdLs+N++
  EFC37088.1 398 LHILIMNFNQiGEGITYLNNTTLKGLTFLLLRSNQIGKyLKGVSFNALPKLGLLDLSNNDI 458
                 666777777733444444445699**********99988999*****************97 PP

  == domain 9  score: 7.9 bits;  conditional E-value: 0.00087
                 SEE-TTSSTT-TT--EEE--SS---GGGG CS
       LRR_8  14 tslddeaFkglsnLkvLdLsnNllttlsp 42 
                 ++l  +  +++++Lk+L+L  N +t  s+
  EFC37088.1 488 SVLIETLSSNFPSLKHLNLQTNPMTQKSK 516
                 44555666778888888888887776665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0      0.03        88       1      18 [.      21      38 ..      21      43 .. 0.79
   2 !    7.5   0.1    0.0027       7.9       1      12 [.      46      57 ..      46      63 .. 0.88
   3 !    5.7   0.2    0.0097        29       2      14 ..      72      84 ..      71      95 .. 0.81
   4 ?    3.9   1.2     0.039   1.2e+02       1      13 [.     123     138 ..     123     157 .. 0.74
   5 ?    0.7   0.6      0.43   1.3e+03       1      23 []     173     195 ..     173     195 .. 0.88
   6 ?   -3.4   0.0         6   1.8e+04       1       8 [.     199     206 ..     199     211 .. 0.79
   7 !    8.5   0.2    0.0012       3.5       1      21 [.     225     245 ..     225     247 .. 0.85
   8 ?    1.6   0.1      0.22   6.7e+02       1      13 [.     249     263 ..     249     284 .. 0.75
   9 ?   -1.5   0.2       2.4   7.1e+03       1       7 [.     296     302 ..     288     313 .. 0.68
  10 ?    3.2   0.1     0.066     2e+02       1      13 [.     320     332 ..     320     351 .. 0.78
  11 ?   -1.9   0.0         3   9.1e+03       1      12 [.     345     356 ..     345     367 .. 0.83
  12 !    5.9   0.0    0.0086        26       1      11 [.     371     381 ..     371     395 .. 0.86
  13 ?   -2.3   0.1       4.4   1.3e+04       1      12 [.     397     408 ..     397     420 .. 0.76
  14 ?   -2.4   0.0       4.7   1.4e+04       2      12 ..     423     433 ..     422     445 .. 0.75
  15 ?    4.9   0.1     0.019        57       4      21 ..     450     467 ..     447     472 .. 0.86
  16 ?    5.4   0.0     0.013        39       1      18 [.     500     517 ..     500     522 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.03
       LRR_1  1 nLrhLdLsnnpllglppn 18
                n  +LdL++n +++++++
  EFC37088.1 21 NIHRLDLEGNKIGRKSIE 38
                6789*******9877665 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0027
       LRR_1  1 nLrhLdLsnnpl 12
                nL++L++s+n++
  EFC37088.1 46 NLKELNISSNRI 57
                8*********98 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0097
       LRR_1  2 LrhLdLsnnpllg 14
                Lr L++s+n++++
  EFC37088.1 72 LRILNVSHNSIGN 84
                9*********854 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.039
       LRR_1   1 nLrhLdLsnnpl...l 13 
                 +L hL+L++n++   +
  EFC37088.1 123 KLAHLNLGGNNIsveG 138
                 688****999984442 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.43
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL++L + n +l +  ++++++L
  EFC37088.1 173 NLTKLRVDNSNLNDGAIECLCKL 195
                 89*****9999988888888876 PP

  == domain 6  score: -3.4 bits;  conditional E-value: 6
       LRR_1   1 nLrhLdLs 8  
                 +L +Ld++
  EFC37088.1 199 KLSSLDIR 206
                 68899995 PP

  == domain 7  score: 8.5 bits;  conditional E-value: 0.0012
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++ +n+l+ l++ s+ 
  EFC37088.1 225 HLKVLNIAHNSLETLGILSLL 245
                 69**********998887775 PP

  == domain 8  score: 1.6 bits;  conditional E-value: 0.22
       LRR_1   1 nLrhLdLsnnpl..l 13 
                 n ++++++ n++   
  EFC37088.1 249 NIESINIEKNSNhgH 263
                 7899***99998441 PP

  == domain 9  score: -1.5 bits;  conditional E-value: 2.4
       LRR_1   1 nLrhLdL 7  
                 nL++L++
  EFC37088.1 296 NLKTLHV 302
                 5666654 PP

  == domain 10  score: 3.2 bits;  conditional E-value: 0.066
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+ nn l 
  EFC37088.1 320 QLTSLDVANNKLC 332
                 599*******993 PP

  == domain 11  score: -1.9 bits;  conditional E-value: 3
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+ L + +n l
  EFC37088.1 345 NLTNLSVAGNEL 356
                 899999999988 PP

  == domain 12  score: 5.9 bits;  conditional E-value: 0.0086
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++L++s+n+
  EFC37088.1 371 KLKTLNISSNN 381
                 7********98 PP

  == domain 13  score: -2.3 bits;  conditional E-value: 4.4
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L  L ++ n++
  EFC37088.1 397 KLHILIMNFNQI 408
                 688899999987 PP

  == domain 14  score: -2.4 bits;  conditional E-value: 4.7
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ L L++n++
  EFC37088.1 423 LTFLLLRSNQI 433
                 77888999987 PP

  == domain 15  score: 4.9 bits;  conditional E-value: 0.019
       LRR_1   4 hLdLsnnpllglppnsfq 21 
                  LdLsnn ++  + ++f+
  EFC37088.1 450 LLDLSNNDIGTEEFACFS 467
                 59*******999999986 PP

  == domain 16  score: 5.4 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L+hL+L  np ++++++
  EFC37088.1 500 SLKHLNLQTNPMTQKSKE 517
                 6*********99888765 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0      0.01        31       1      17 [.      46      62 ..      46      64 .. 0.85
   2 ?    0.1   0.1      0.49   1.5e+03       1       6 [.     296     301 ..     296     303 .. 0.89
   3 ?    4.1   0.0     0.028        85       1      12 [.     371     382 ..     371     387 .. 0.82
   4 ?   -0.6   0.1      0.84   2.5e+03       1       9 [.     500     508 ..     500     509 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.01
       LRR_2  1 sLKtLhLdsVrfsdeds 17
                +LK L+++s+r++++++
  EFC37088.1 46 NLKELNISSNRIDSGAC 62
                69**********87765 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.49
       LRR_2   1 sLKtLh 6  
                 +LKtLh
  EFC37088.1 296 NLKTLH 301
                 6****9 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.028
       LRR_2   1 sLKtLhLdsVrf 12 
                 +LKtL+++s+  
  EFC37088.1 371 KLKTLNISSNNV 382
                 6********975 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 0.84
       LRR_2   1 sLKtLhLds 9  
                 sLK L+L +
  EFC37088.1 500 SLKHLNLQT 508
                 8******86 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.1    0.0017       5.1      10     105 ..      13     113 ..       7     155 .. 0.66
   2 ?    0.8   0.7     0.098   2.9e+02      57     127 ..     139     212 ..     118     232 .. 0.66
   3 ?    0.2   1.3      0.15   4.6e+02      43     121 ..     178     256 ..     156     264 .. 0.63
   4 ?    3.2   3.3     0.019        55      63     128 ..     294     359 ..     273     378 .. 0.74
   5 ?    4.6   0.6    0.0068        20      65     127 ..     371     435 ..     362     457 .. 0.58
   6 ?    8.3   0.5   0.00051       1.5      48     105 ..     452     516 ..     445     530 .. 0.57

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0017
       LRR_9  10 kqsaqyinairereldlrgykip..vienlGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivri.aegle....evlPnleelvltnnelq 101
                 k +++y   i+   ldl g+ki    ie l a l  +  +++s n i     + l k l+ l + n     i +egle      l +le l  tn +++
  EFC37088.1  13 KACTEYASNIH--RLDLEGNKIGrkSIELLSAGLVNLKELNISSNRIDSGACYYLAKELRFLRILNVSHNSIgNEGLEylmsGNLVELERLECTNVKIN 109
                 55556666654..48889999853379999999999999999999999998888877666665544444444134444111134556666666766666 PP

       LRR_9 102 elad 105
                 + ++
  EFC37088.1 110 DEGT 113
                 6555 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.098
       LRR_9  57 ldgfPllkrlktlllnnnri..vriaegleevlPnleelvltnnelqeladldPlaslkk..lellsllknpvtn 127
                   ++ ll  l +l l++  +    +++  +  l nl++l + n++l++ + ++ l +l +  l++l +  n vtn
  EFC37088.1 139 CKNVALLSSLTSLNLSDIDVsvAAMENICKGKLENLTKLRVDNSNLND-GAIECLCKLANfkLSSLDIRINQVTN 212
                 566777777777777765441033444456789999999999999988.55788888876114455555666665 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.15
       LRR_9  43 qfdtidlsdndirkldgfPllkrlktlllnnnrivriaegl..eevlPnleelvltnnelqeladldPlaslkklellsll 121
                 + d  +l+d  i  l  +  + +l +l +  n++++ + ++  + +  +l+ l +++n+l+ l+ l  l  + ++e++ + 
  EFC37088.1 178 RVDNSNLNDGAIECLCKLANF-KLSSLDIRINQVTNEGADMiaKSMNAHLKVLNIAHNSLETLGIL-SLLFMDNIESINIE 256
                 456666666666666665555.36677777777776665542223334577777777777777754.45556666666665 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.019
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                  + lktl ++   ++  + +l  +  +l++l ++nn+l + +     ++l++l++ls+  n +t +
  EFC37088.1 294 NNNLKTLHVALSNLTTESIELISTRTQLTSLDVANNKLCDTNVKTITTKLSNLTNLSVAGNELTYQ 359
                 467888888888888888888888888888888888888877766777888888888888887755 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.0068
       LRR_9  65 rlktlllnnnrivriaeg..leevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 +lktl +++n +   + +  +     +l+ l+++ n++ e  +    ++lk l++l l +n + +
  EFC37088.1 371 KLKTLNISSNNVGAEGAKalFLGNTTKLHILIMNFNQIGEGITYLNNTTLKGLTFLLLRSNQIGK 435
                 56666666666644333211223445677777777777777777777777777777776666543 PP

  == domain 6  score: 8.3 bits;  conditional E-value: 0.00051
       LRR_9  48 dlsdndirk.......ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqelad 105
                 dls+ndi          + fPll  l++ + +  r+  + e l+   P+l++l l+ n +++ ++
  EFC37088.1 452 DLSNNDIGTeefacfsQQKFPLLSTLNCGMNAITRVSVLIETLSSNFPSLKHLNLQTNPMTQKSK 516
                 55555554311111112456666666666555566666667777777888888777777766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (531 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       674  (0.0375927); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 3260.26
//
Query:       EFC37089.1  [L=299]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.4e-12   44.3   8.4      0.007   16.3   0.0    7.3  7  NHL       NHL repeat
     0.0063   16.4   0.1       0.85    9.6   0.0    2.4  2  DUF4934   Domain of unknown function (DUF4934)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.013   1.2e+02      15      28 .]      13      26 ..      12      26 .. 0.92
   2 ?   -0.4   0.1      0.16   1.5e+03      14      22 ..      63      71 ..      63      74 .. 0.84
   3 ?   -2.5   0.0      0.73   6.6e+03       1       7 [.     125     131 ..     125     137 .. 0.78
   4 !    5.8   0.0    0.0017        16      14      25 ..     145     156 ..     143     159 .. 0.88
   5 !   12.4   0.0   1.4e-05      0.13       1      27 [.     179     204 ..     179     205 .. 0.92
   6 ?    3.0   0.7     0.013   1.2e+02       1      10 [.     221     230 ..     221     245 .. 0.60
   7 !   16.3   0.0   7.8e-07     0.007       1      26 [.     268     294 ..     268     295 .. 0.96

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.013
                EEEEECCCTEEEEE CS
         NHL 15 iyVaDsenhrvqvF 28
                ++++D+  ++++++
  EFC37089.1 13 LFITDYDKSCIRIY 26
                689********997 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.16
                EEEEEECCC CS
         NHL 14 diyVaDsen 22
                +iyV+++ n
  EFC37089.1 63 EIYVTCRSN 71
                69****766 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.73
                 BSSEEEE CS
         NHL   1 fnyPhGv 7  
                 f++P+G+
  EFC37089.1 125 FYFPRGL 131
                 7889987 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0017
                 EEEEEECCCTEE CS
         NHL  14 diyVaDsenhrv 25 
                 +++V++s+n+r+
  EFC37089.1 145 QLLVCNSGNNRI 156
                 79*********9 PP

  == domain 5  score: 12.4 bits;  conditional E-value: 1.4e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f +P G++ + ++++++aD +n  vqv
  EFC37089.1 179 FDRPVGISKF-SNELFIADHNNGLVQV 204
                 7899999999.9**************9 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.013
                 BSSEEEEEEE CS
         NHL   1 fnyPhGvavd 10 
                 +n+P+G+++ 
  EFC37089.1 221 LNCPRGICAI 230
                 6788888865 PP

  == domain 7  score: 16.3 bits;  conditional E-value: 7.8e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvq 26 
                 f+ P+G++ +    +i++aD en r+q
  EFC37089.1 268 FALPEGICFNsERSEILIADWENKRIQ 294
                 788***********************9 PP

>> DUF4934  Domain of unknown function (DUF4934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.6   0.0    0.0035        31      22     100 ..     133     211 ..     129     213 .. 0.66
   2 !    9.6   0.0   9.5e-05      0.85      29      61 ..     227     259 ..     222     295 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0035
     DUF4934  22 LvGnspkikllkdkivvss.kkqCllfdketGkflasvGhiGedPegysevagwlndatgllyfsrkpdklvkydakGef 100
                 L+    + +l k+ +v  s +++   ++ e+G+f +s G    d + +   +g+ + +++l+   ++++ +++   +G+f
  EFC37089.1 133 LIDSDENSNLGKQLLVCNSgNNRIDCLNPENGQFTKSFGSEKGDGK-FDRPVGISKFSNELFIADHNNGLVQVLTLDGQF 211
                 666777778888888888888899999************8766644.333444444444444444444455566666666 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 9.5e-05
     DUF4934  29 ikllkdkivvsskkqCllfdketGkflasvGhi 61 
                 i+ +++  +v+ +++ +lf+ e+G+ l+s+G +
  EFC37089.1 227 ICAIENMCLVTDNHRIQLFNSENGQLLQSIGSL 259
                 677889999999*******************64 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1772.14
//
Query:       EFC37090.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      6e-11   42.5   0.0    1.2e-10   41.5   0.0    1.5  1  Peptidase_C26  Peptidase C26
    1.3e-05   25.1   0.0      3e-05   23.9   0.0    1.6  1  GATase         Glutamine amidotransferase class-I
  ------ inclusion threshold ------
      0.016   14.1   0.0      0.024   13.5   0.0    1.2  1  BTV_NS2        Bluetongue virus non-structural protein NS2
      0.032   14.0   0.3      0.048   13.4   0.3    1.2  1  Cytochrom_C1   Cytochrome C1 family


Domain annotation for each model (and alignments):
>> Peptidase_C26  Peptidase C26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.5   0.0   2.7e-14   1.2e-10      82     216 .]     151     320 ..     143     320 .. 0.73

  Alignments for each domain:
  == domain 1  score: 41.5 bits;  conditional E-value: 2.7e-14
  Peptidase_C26  82 keeeadpeRdalelaLiraalergvPilgiCrGlqllnvalGGt...lyqdieeqsgltdhrehe.............q...saashavkve.... 154
                    ++++    R ++e  +ir+a+  g P+l+iC G   l   lGG+   +++d++++sg+ +  ++              q            +    
     EFC37090.1 151 ENDPSMIFRFEFERNVIRKAMLIGQPVLCICSGSWRLWEFLGGSvsnINSDVQHASGMINLDSNGtikhqqvghgiilQheaNDIDL----Dirip 242
                    66777778999********************************72225678888777777655556665444444433132233333....24465 PP

  Peptidase_C26 155 kgsllaell...........gseeievnslHhqaike.....laeelrveAvae.DgviEaieseeakafvlgvQwHPE 216
                    + ++l++ +           +s+ i+vns+H +a +      l++ + ++A +  D  iEa+e++   ++++g+QwHPE
     EFC37090.1 243 ECTILKSSMygksanekivdESHAISVNSIHWMAPQLpknspLENIVDISALSIpDYSIEAFETKF-GVPIIGIQWHPE 320
                    5555555444554466555447779999999999776777889999******987*********99.67*********9 PP

>> GATase  Glutamine amidotransferase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.0   6.6e-09     3e-05      58     181 ..     161     329 ..     150     337 .. 0.77

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 6.6e-09
                 TTHHHHHHHHCTSTS-EEEETHHHHHHHHHTTTEEE.......EEECEEEEEEEEEEEETTT...........................CGGTTTTSEE CS
      GATase  58 egkieaikearenkiPiLGICLGmQllaiefgrkvv.......kekekehhggtmrlgddet...........................allyglknev 122
                 e + ++i++a+  + P+L IC G   l + +g++v        +++   ++  +  +++++                            + + ++ ne 
  EFC37090.1 161 EFERNVIRKAMLIGQPVLCICSGSWRLWEFLGGSVSninsdvqHASGMINLDSNGTIKHQQVghgiilqheandidldiripectilksSMYGKSANEK 259
                 6677889999999********************6666555555444444444444444444466666666778899999999999***76666677899 PP

                 EEEEEEEEEEESG..........CHHHTTEEEEEEEETTEEEEEEEEETT.TEEEESSBTTSTTSTTHHH CS
      GATase 123 ierhrHryevnpk..........elepaglevtakseddeelmeiiekkn.pfvgvQFHPEststpegpe 181
                 i+  +H   vn            + +++ ++++a s  d +++++  k   p++g+Q+HPE+    +++e
  EFC37090.1 260 IVDESHAISVNSIhwmapqlpknSPLENIVDISALSIPDYSIEAFETKFGvPIIGIQWHPEAYILNNEQE 329
                 999999999997688998888877777779*********8888888888899*********976666555 PP

>> BTV_NS2  Bluetongue virus non-structural protein NS2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   5.3e-06     0.024      78     179 ..     171     278 ..     152     286 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.3e-06
                 EE-SS-EEE.ESS--TTB--EEEE-EEEEEEEEETTEEEEEE....EEEEE.----S-TT-BSS--CCC----TT-EE-SS-HHHH---XXXXXXXXXX CS
     BTV_NS2  78 mltphgvea.tterweewkfegvsvtpmatrvqyngvmvdae....ikyck.gmgivqpymrndfdrnempdlpgvmrsnydirelrqkikneresapr 170
                 ml  + v +  +  w  w+f g sv+ + + vq+   m++ +    ik+ + g gi+  +  nd+d +       +++s    +   +ki +e  +   
  EFC37090.1 171 MLIGQPVLCiCSGSWRLWEFLGGSVSNINSDVQHASGMINLDsngtIKHQQvGHGIILQHEANDIDLDIRIPECTILKSSMYGKSANEKIVDESHAISV 269
                 55555544315678********************9999864322338876449*************986555567888888889999******999999 PP

                 XXXXXXXXX CS
     BTV_NS2 171 lqvhsvapr 179
                   +h +ap+
  EFC37090.1 270 NSIHWMAPQ 278
                 999999986 PP

>> Cytochrom_C1  Cytochrome C1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.3   1.1e-05     0.048     111     167 ..      38      96 ..      21     118 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.1e-05
  Cytochrom_C1 111 ggadYiyslLtgYeeppagvev..kegqyyNkyfpggviamakpLsdgqveyedgtpat 167
                   + a+ iy+lL+ +++p+++++   ++ ++ N+     v  m kp+   +v+y++g ++ 
    EFC37090.1  38 HDAKLIYELLQNFSNPNQNINNnnNNMNNNNNRNVKYVATMIKPMNGKVVNYSEGIRKI 96 
                   77889**********9998887323334444455667789**************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       899  (0.0501422); expected 358.6 (0.02)
Passed bias filter:                      437  (0.0243739); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 2089.21
//
Query:       EFC37091.1  [L=369]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.8e-15   55.0   0.0      3e-12   46.3   0.0    2.2  2  Hydrolase_4    Serine aminopeptidase, S33
    1.2e-13   51.4   0.3    4.3e-13   49.5   0.2    1.8  2  Abhydrolase_1  alpha/beta hydrolase fold
    1.2e-07   32.6   0.0    1.6e-07   32.1   0.0    1.2  1  Abhydrolase_6  Alpha/beta hydrolase family
      3e-07   30.1   0.6      0.007   15.9   0.0    2.4  2  Peptidase_S9   Prolyl oligopeptidase family
  ------ inclusion threshold ------
      0.028   13.2   0.0      0.042   12.6   0.0    1.2  1  Peptidase_S28  Serine carboxypeptidase S28
       0.08   12.8   0.0       0.19   11.7   0.0    1.6  2  BAAT_C         BAAT / Acyl-CoA thioester hydrolase C terminal
        0.1   11.9   0.6       0.34   10.2   0.0    2.1  3  DUF915         Alpha/beta hydrolase of unknown function (DUF9
       0.11   12.1   0.0       0.31   10.5   0.0    1.7  2  DLH            Dienelactone hydrolase family


Domain annotation for each model (and alignments):
>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.3   0.0   1.3e-15     3e-12       3     113 ..      80     200 ..      78     244 .. 0.82
   2 !    6.6   0.0    0.0018       4.1     187     239 .]     284     337 ..     281     337 .. 0.92

  Alignments for each domain:
  == domain 1  score: 46.3 bits;  conditional E-value: 1.3e-15
  Hydrolase_4   3 pkavvvlvHGlaehsgryael.......aeaLaaqGfavyalDhrGhGrse..gkrg.hvpsfddyvdDlaafvekvkeehpelplfllGhSmGGlia 90 
                  p+ vv++vHG +  s+   +l       ++ +a qG+++y ++ rG+G s    ++g  + ++++  dD a++v+ + ++ + +++ ++G S+G  ia
   EFC37091.1  80 PDNVVLFVHGATYPSETSYDLvlggmswMDFMAMQGYDTYFINVRGYGDSTrpANTGePIVRTTTAADDYATAVKYILRRRNISKMNIMGWSWGTSIA 177
                  7889999999988887665542333333589*******************9984444357999*********************************** PP

  Hydrolase_4  91 llyllrypdkvaglilsaPalki 113
                  ++++++yp+  ++l++ aP    
   EFC37091.1 178 TTFATNYPELTNRLVIYAPQWYR 200
                  *********888*******8544 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0018
  Hydrolase_4 187 aakitlPllllhGeaDkvvdpeasrelyerlgsk.dktlklypglyHellnEpd 239
                   +k+++P+l++ +e D   + + s  ++++l++   k++  +p++ H++l E++
   EFC37091.1 284 STKLNMPVLVIRAEWDADLNIDMSLGYFKNLTQVpYKKFVQIPEGTHQVLLEKN 337
                  57899*******************999999988779***************986 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.5   0.2   1.9e-16   4.3e-13       1     107 [.      82     202 ..      82     280 .. 0.80
   2 ?   -0.1   0.0      0.27   6.1e+02     190     255 ..     268     335 ..     261     337 .. 0.76

  Alignments for each domain:
  == domain 1  score: 49.5 bits;  conditional E-value: 1.9e-16
                    SEEEEE-STTT....CGGG......GTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB.....CHHSHHHHHHHHHHHHHHCTTSSEEEEEETH CS
  Abhydrolase_1   1 pvlvilhGlpg....ssdv......waerglapaLakdgfdvillDlrGvgySspapacin....ddygtasvaddldrildalgddkltlvGhSm 82 
                    +v++++hG +     s d+      w+        a +g+d++ +++rG+g S+++ ++      ++   +++a  +++il + ++ k +++G+S+
     EFC37091.1  82 NVVLFVHGATYpsetSYDLvlggmsWMD-----FMAMQGYDTYFINVRGYGDSTRPANTGEpivrTTTAADDYATAVKYILRRRNISKMNIMGWSW 172
                    6899999998877763333555333555.....44556********************99999887778888999999****************** PP

                    HHHHHHHHHHHHGGGEEEEEEESE.....C CS
  Abhydrolase_1  83 GGmialayaaeyperVkalvllga.....i 107
                    G+ ia+++a  ype  ++lv  ++      
     EFC37091.1 173 GTSIATTFATNYPELTNRLVIYAPqwyrnF 202
                    ***************999999888444443 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.27
                    HHHHHCCHHHHHHHHHCTHHHHSEEEEEEETTCSSSCH.HHHHHHHHC..HTSEEEEEEETCSSSHHHH CS
  Abhydrolase_1 190 eqwpttdsaklllrlrelknvlaptlvisgtsDplvpp.kaledlaql..lpkkrlvvisdagHlafle 255
                     + ++++++++++ +++ ++ + p+lvi ++ D    +  +l ++++l   p k+ v+i+ + H ++le
     EFC37091.1 268 VYDNNEYWFNSINIYNS-TKLNMPVLVIRAEWDADLNIdMSLGYFKNLtqVPYKKFVQIPEGTHQVLLE 335
                    56677788888888888.77788*****99988888886666777777666668888888888888877 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.0   7.3e-11   1.6e-07       1     213 [.      84     336 ..      84     344 .. 0.59

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 7.3e-11
                    EEEE--GC...............GC.HHHHHHHHCCTCEEEEE--TTSTS-GGCS.......--HHHCHHHHHHHCCTT..TTSE...EEEEETCH CS
  Abhydrolase_6   1 vlllHGagss..........assWl.vapLaallaagvhvlapDlpGhGrsdppp.......ldledladlaalldelaagggpv...vlvGHSlG 75 
                    vl++HGa ++          + sW  ++ +     +g+ ++ +  +G+G+s++p+        + ++++d+a ++  +  +++++    ++G+S+G
     EFC37091.1  84 VLFVHGATYPsetsydlvlgGMSWMdFMAM-----QGYDTYFINVRGYGDSTRPAntgepivRTTTAADDYATAVKYIL-RRRNIskmNIMGWSWG 173
                    89****775554444444445667423344.....3455578*******555555555445533333577777777776.33334677******** PP

                    HHHHHHHHHCC........EE.EEES-..----TTTS----TTHHHHHHTT-CCCCHCCH.S-HS.CCCCHHHCCCCHCHCCCGHH.......... CS
  Abhydrolase_6  76 Galalaaapla......lvvg.vlldppptalpagllaaalelllallallrllawlsre.plpr.lfladedadaawrarlarla.......... 152
                    +++a+     a         + v+++p   ++   ++  +   ++  +   r++ wl++  ++ + ++++     a w + +  +           
     EFC37091.1 174 TSIATT---FAtnypelT-NRlVIYAP---QWYRNFQTKVSGSYRNTTIEGRRASWLTGVaADKQnSIIP-----AGWYEIWESVTfakalvnekg 257
                    ******...444446843.336*****...******9999999999999999999997664222246666.....555555555553333344555 PP

                    ............HHCC..HHC.HTTCCHHTT-TTGCEEE.CTT-CHHHHCHHCCCH..STTEEET....CE...SSS-HHHHS CS
  Abhydrolase_6 153 ............alla..glg.llpaaawadlpvpllvl.ggeDplvprllerlla..qagarlp....vvlpgaGHlphlee 213
                                +  +  +++   +  + + l +p+lv+ ++ D+ +   ++  l   ++  ++p    v +p + H ++le+
     EFC37091.1 258 vkylstptgivyD--NneYWFnSINIYNSTKLNMPVLVIrAEWDADLN--IDMSLGyfKNLTQVPykkfVQIPEGTHQVLLEK 336
                    5443333333221..122222233455666666666777755555444..444444444444444555588888888555544 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.1   3.8e-05     0.086       8      95 ..     109     194 ..     105     222 .. 0.81
   2 !   15.9   0.0   3.1e-06     0.007     124     207 ..     270     351 ..     240     354 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.8e-05
                   HHHHCCT-EEEEE--TTSSTTHCHHHHTTSGGGGHHHHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHHHHHHHHH-GGG-SEEEEE CS
  Peptidase_S9   8 qlladrGyvvvvanirGsggyGeafhdagkrklgqnefdDfiaaaealakegyvdserlaitGgSyGGyltgaalnqrpdlFkaavae 95 
                    ++a +Gy   ++n+rG g+  +  +        +  +dD+ +a++++  +  +  +++ i+G+S G   + + +++ p+l   +v+ 
    EFC37091.1 109 DFMAMQGYDTYFINVRGYGDSTRPANTGEPIVRTTTAADDYATAVKYILRRRNI--SKMNIMGWSWGTSIATTFATNYPELTNRLVIY 194
                   5788999999999999988666655554444455667899********999988..8999*******999999999999886665555 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 3.1e-06
                   CHHHHHHHHHH-CGGG-----EEEEEEETT-SSS-THHHHHHHHHHH--S-S.EEEEEETTS-SSTTSSHHHHHHHHHHHHHHHH CS
  Peptidase_S9 124 neegykelspyspldnvkaypplLlihGlaDdrvppaealklvaaLqkkgkn.vlllifpdegHgvgkprakveelarllaFlke 207
                   ++++y ++++++ ++  k + p+L+i +++D    +  +l ++++L++  ++  +++  p+  H v  ++++ + ++++ +Fl e
    EFC37091.1 270 DNNEY-WFNSINIYNSTKLNMPVLVIRAEWDADLNIDMSLGYFKNLTQ--VPyKKFVQIPEGTHQVLLEKNRMALFREVQHFLTE 351
                   45558.999999999999****************************86..887899999***********************976 PP

>> Peptidase_S28  Serine carboxypeptidase S28
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.9e-05     0.042      24     138 ..      78     188 ..      65     192 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.9e-05
  Peptidase_S28  24 fyknggpiflyiGgegslsaswvsng..eilklAkefgAlvlslEHRfYGqSiPvkdlstenlrylsseqaLaDlasfikalkqkfklsssskwit 117
                    +  ++  +f++     s+++++   g   ++++ + +g + +++  R YG+S   +++  +    + ++ a  D a ++k + ++ ++s+ +   +
     EFC37091.1  78 YSPDNVVLFVHGATYPSETSYDLVLGgmSWMDFMAMQGYDTYFINVRGYGDSTRPANTGEPI---VRTTTAADDYATAVKYILRRRNISKMN---I 167
                    55555555555555555556655555588999999999999***********8555555544...55677889**********999888887...9 PP

  Peptidase_S28 118 fGgSYsgsLaawarkkyPelv 138
                    +G S++ s+a+ +   yPel+
     EFC37091.1 168 MGWSWGTSIATTFATNYPELT 188
                    9******************97 PP

>> BAAT_C  BAAT / Acyl-CoA thioester hydrolase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       3.1     7e+03     109     128 ..      43      62 ..      17      78 .. 0.62
   2 ?   11.7   0.0   8.3e-05      0.19       6      61 ..     149     202 ..     147     234 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.1
                 --GGG--SEEEEEEETT-SS CS
      BAAT_C 109 ipvekakgpillvvgedDkn 128
                 ++ ek   +  ++ ++dD n
  EFC37091.1  43 FNNEKVIQADFFIRAQDDSN 62 
                 33444433334556666655 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 8.3e-05
                 HHHHHHHHHCSTTB--SSEEEEEETHHHHHHHHHHHHSSSEEEEEEES--SB--SS CS
      BAAT_C   6 FeeainyllrhpkvkkdkigllGiSkGgelalllasflkkisavvlingsavvveg 61 
                 +  a++y+lr+ +++  k+ ++G S G  +a   a+ +++ ++  +i +++   ++
  EFC37091.1 149 YATAVKYILRRRNIS--KMNIMGWSWGTSIATTFATNYPELTNRLVIYAPQWYRNF 202
                 5689*******9998..9*********************99998887777665555 PP

>> DUF915  Alpha/beta hydrolase of unknown function (DUF915)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.3     3e+03     143     193 ..      43      90 ..      29      99 .. 0.56
   2 ?   -2.2   0.1      0.92   2.1e+03     113     130 ..     103     120 ..     102     124 .. 0.86
   3 ?   10.2   0.0   0.00015      0.34      91     125 ..     151     185 ..     141     193 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.3
      DUF915 143 fngienndedetlaqvkkdgpkkktqaykkllknqkkkipkdlevlniaGd 193
                 fn++++ ++d   ++ ++d+ +   q+ +k     kk+ p+++ vl + G+
  EFC37091.1  43 FNNEKVIQAD--FFIRAQDDSNILLQMRNKRKPSTKKYSPDNV-VLFVHGA 90 
                 5555555444..4444455566666666666666444444444.5555554 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.92
      DUF915 113 GglaltsYleeyaddksl 130
                 Gg++++ +++  ++d  +
  EFC37091.1 103 GGMSWMDFMAMQGYDTYF 120
                 9********999998765 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00015
      DUF915  91 kvlseLkkkYnikkfnavGhSmGglaltsYleeya 125
                  +++++  + ni k+n++G+S G + +t ++ +y 
  EFC37091.1 151 TAVKYILRRRNISKMNIMGWSWGTSIATTFATNYP 185
                 6788888899*********************9996 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00014      0.31      76     130 ..     143     195 ..     111     217 .. 0.79
   2 ?   -2.3   0.0       1.1   2.6e+03     135     159 ..     279     303 ..     274     316 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00014
         DLH  76 ekvlddlkaavaylksvpevstkkvgvvGfCmGGalalllaaevpevdaavafYG 130
                     dd   av+y+  ++  + +k+ ++G+ +G  +a  +a++ pe+   ++ Y 
  EFC37091.1 143 TTAADDYATAVKYILRRR--NISKMNIMGWSWGTSIATTFATNYPELTNRLVIYA 195
                 366788889999999999..557********************977766555554 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.1
         DLH 135 keleeaakikapilalfgeeDefip 159
                  ++ + +k++ p+l++ +e D   +
  EFC37091.1 279 INIYNSTKLNMPVLVIRAEWDADLN 303
                 5677788999999999999887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (369 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       519  (0.0289475); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 2044.83
//
Query:       EFC37092.1  [L=430]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-09   38.7   0.1      0.081   13.6   0.0    4.2  4  RCC1      Regulator of chromosome condensation (RCC1) repeat
    4.3e-08   32.8   0.4    2.3e-05   24.1   0.0    3.2  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0    0.0003       2.6      15      48 ..      10      53 ..       9      54 .. 0.62
   2 !   10.5   0.0   8.4e-05      0.75      24      50 .]     244     275 ..     227     275 .. 0.73
   3 !   13.6   0.0   9.1e-06     0.081       1      43 [.     278     327 ..     278     334 .. 0.62
   4 ?   -0.4   0.0       0.2   1.8e+03      38      48 ..     383     393 ..     370     394 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0003
                TSSSS---EEEE.......EE-GGGTTS...-EEEEEEETTEEE CS
        RCC1 15 LGlgttesvlvP.......tkveglsgn...rvvkvacGddhtv 48
                LG+++t   +vP        + + +++n   +v k++cG+++ v
  EFC37092.1 10 LGIQPTSGIHVPmpkwepyFLHPIPNSNystEVRKISCGGNFFV 53
                7777774444442233334333566666778*********9865 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 8.4e-05
                 EEEEE-.....GGGTTS-EEEEEEETTEEEEE CS
        RCC1  24 lvPtkv.....eglsgnrvvkvacGddhtval 50 
                   P++v     ++++g+r+ ++ cG++ht +l
  EFC37092.1 244 GQPSEVfsqlkTPFQGKRIDQIKCGYFHTSVL 275
                 45777766666778888************775 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 9.1e-06
                 TTEEEEEE--GGGTTSSSS---E.......EEEEE-GGGTTS-EEEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesv.......lvPtkveglsgnrvvkvacG 43 
                 +G+Vy +G n y q+G   +++        l+P   ++++    + ++c 
  EFC37092.1 278 SGEVYMCGYNGYFQCGVVGSDQYfikidfpLLPYDSQNSKIFQPTRITCS 327
                 69***************666555344444444544444443355555554 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.2
                 EEEEEETTEEE CS
        RCC1  38 vkvacGddhtv 48 
                  ++ cG+ h v
  EFC37092.1 383 NSIECGGWHFV 393
                 5899****965 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.8   0.0    0.0028        25       1      13 [.      42      54 ..      42      56 .. 0.89
   2 !   24.1   0.0   2.5e-09   2.3e-05       3      30 .]     264     291 ..     262     291 .. 0.92
   3 ?   -0.7   0.0      0.15   1.4e+03       3      12 ..     384     393 ..     384     394 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0028
      RCC1_2  1 VksvsaGdyHsca 13
                V+++s+G++++++
  EFC37092.1 42 VRKISCGGNFFVV 54
                789*******997 PP

  == domain 2  score: 24.1 bits;  conditional E-value: 2.5e-09
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++ +G++H+ +L+e+GeV+ +G N++ Q
  EFC37092.1 264 QIKCGYFHTSVLLESGEVYMCGYNGYFQ 291
                 899*********************9866 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.15
      RCC1_2   3 svsaGdyHsc 12 
                 s+ +G+ H++
  EFC37092.1 384 SIECGGWHFV 393
                 789*****87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (430 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       369  (0.0205812); expected 358.6 (0.02)
Passed bias filter:                      257  (0.0143343); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 2608.69
//
Query:       EFC37093.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.8e-23   81.7   8.6    0.00011   22.9   0.0    7.2  7  WD40         WD domain, G-beta repeat
      3e-17   62.6  13.5      7e-17   61.5  13.5    1.6  1  Sof1         Sof1-like domain
    2.8e-05   24.1   0.1    0.00075   19.4   0.2    2.7  2  eIF2A        Eukaryotic translation initiation factor eIF2A
    3.1e-05   24.0   0.2        8.9    6.4   0.0    4.5  5  BBS2_Mid     Ciliary BBSome complex subunit 2, middle region
    3.3e-05   24.1   0.1        1.1    9.6   0.0    3.9  4  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    0.00045   19.6   0.3       0.13   11.6   0.0    3.4  4  WD40_like    WD40-like domain
  ------ inclusion threshold ------
      0.046   12.4   0.2        4.9    5.7   0.0    2.6  3  Nup160       Nucleoporin Nup120/160
          1   10.4   7.6        2.8    9.0   7.6    1.7  1  Spt5_N       Spt5 transcription elongation factor, acidic N-t


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.3   1.8e-07    0.0004       6      38 .]      63      97 ..      59      97 .. 0.86
   2 ?    4.3   0.0     0.037        83       8      37 ..     109     147 ..     102     148 .. 0.79
   3 ?    5.5   0.4     0.015        34       4      38 .]     192     225 ..     189     225 .. 0.88
   4 ?    1.3   0.0      0.32   7.2e+02      12      38 .]     256     283 ..     244     283 .. 0.68
   5 ?    2.7   0.0      0.12   2.6e+02      15      35 ..     301     322 ..     293     325 .. 0.83
   6 !   21.1   0.0   1.9e-07   0.00042       6      37 ..     336     368 ..     332     369 .. 0.89
   7 !   22.9   0.0   5.1e-08   0.00011      13      38 .]     389     414 ..     378     414 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 1.8e-07
                EEESS.SSEEEEEEETTSSE.EEEEETTSEEEEEE CS
        WD40  6 tltGH.ssvtslafspdgaw.lasGsdDgtvriWd 38
                 l+GH +  t ++++p++   ++sGs Dg +r+Wd
  EFC37093.1 63 DLSGHaDTPTTICTDPNSLIhILSGSCDGQIRVWD 97
                689**6668***********445**99*******9 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.037
                 ESS.SSEEEEE.........EETTSSEEEEEETTSEEEEE CS
        WD40   8 tGH.ssvtsla.........fspdgawlasGsdDgtvriW 37 
                 ++H ++v+++           s ++ +++ G+ D++++ W
  EFC37093.1 109 RAHnGFVNGIVippyrhssdSSENSYYFSVGT-DKHLKRW 147
                 58955599999888888887788888898899.****988 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.015
                 EEEEESSSSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGHssvtslafspdgawlasGsdDgtvriWd 38 
                 l+   +H+   +++ + + + +++++    ++iWd
  EFC37093.1 192 LQDVVAHNALLCIDHHYSDPIVVTSG-HEYIHIWD 225
                 66667999999************999.999***98 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.32
                 SEEEEEEETTSSEEEE.EETTSEEEEEE CS
        WD40  12 svtslafspdgawlas.GsdDgtvriWd 38 
                  ++s++f++  + l++ + +D+tv ++d
  EFC37093.1 256 TIYSVKFNKVEKNLIAyCARDRTVGLYD 283
                 48899877777777644567***98887 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.12
                 EEEEETTSSEEEEEE.TTSEEE CS
        WD40  15 slafspdgawlasGs.dDgtvr 35 
                  ++++p +++++s+  +Dg+v+
  EFC37093.1 301 KVCWNPMNPFHFSAAnEDGNVY 322
                 699*******9977438*9996 PP

  == domain 6  score: 21.1 bits;  conditional E-value: 1.9e-07
                 EEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   6 tltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                   +GH + v +++++p+g+ ++++++D++vri+
  EFC37093.1 336 MHSGHiNAVLDVDYNPSGTEIVTAGYDKSVRIF 368
                 457*******************9999******8 PP

  == domain 7  score: 22.9 bits;  conditional E-value: 5.1e-08
                 EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  13 vtslafspdgawlasGsdDgtvriWd 38 
                 v  +++s dg+++ sGsdD+++riW+
  EFC37093.1 389 VFTVKYSGDGRYIYSGSDDQSIRIWK 414
                 8899*********************6 PP

>> Sof1  Sof1-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.5  13.5   3.1e-20     7e-17       7      82 ..     423     498 ..     418     505 .. 0.89

  Alignments for each domain:
  == domain 1  score: 61.5 bits;  conditional E-value: 3.1e-20
        Sof1   7 lgvlsaReraaleyreaLkekykhmpeikrIarhRhvPkaikkakkekremkeaekrKeenrrkhskkgsvprkse 82 
                  g ls++e+a++ey+++L e+yk+++++++Ia hRh+P  ik+++ke+++++eae+r+e+ r++ +kk+  ++ s 
  EFC37093.1 423 GGGLSKKEQAQIEYNQKLIERYKNVEDVRKIAAHRHLPHRIKTQSKEMQKEREAEERREKVRERFTKKKDDKKNSM 498
                 5789**************************************************************8886554444 PP

>> eIF2A  Eukaryotic translation initiation factor eIF2A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.14   3.2e+02     121     142 ..      87     108 ..      68     115 .. 0.81
   2 !   19.4   0.2   3.3e-07   0.00075      58     168 ..     254     366 ..     243     389 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.14
                 TSSS-EEEEEETTTTEEEEEEE CS
       eIF2A 121 gnlaGeleiwdvkkkkkiakae 142
                 g+  G++ +wd +++k+i  ++
  EFC37093.1  87 GSCDGQIRVWDLTERKTIYAID 108
                 5788*********999987765 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 3.3e-07
                 SSS.EEEEEE-TTSS-EEEEESSSSCEEEEEECSCEEEEE..EEEES--EEEE-TTSSEEEEE-TTSSS-EEEEEETT...TTEEEEEEE-TT--.EEE CS
       eIF2A  58 kegpihdvaWspkskefaviyGkmpakvslfdlkvkvisk..leeqkrNtiffspkgklvllaGfgnlaGeleiwdvk...kkkkiakaeaanat.lve 150
                 +e  i+ v+ ++ +k+ ++ y   +++v l+d++ +++ +  + + k N + ++p + +   a   n  G++  +d+    k   + +  + na+ +v+
  EFC37093.1 254 TE-TIYSVKFNKVEKN-LIAYCARDRTVGLYDMRTNQMIRavTMQTKSNKVCWNPMNPFHFSAA--NEDGNVYTFDMRileKGPLMMHSGHINAVlDVD 348
                 33.5999999987776.58899***********977665412567889***********99996..888********96644456888888888746** PP

                 E-TTSSEEEEEE-TTT-S CS
       eIF2A 151 wspdgryvlTattaprlr 168
                 ++p+g+ ++Ta    ++r
  EFC37093.1 349 YNPSGTEIVTAGYDKSVR 366
                 **********98765555 PP

>> BBS2_Mid  Ciliary BBSome complex subunit 2, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.72   1.6e+03      14      29 ..      83      98 ..      76     111 .. 0.75
   2 !    6.3   0.0    0.0043       9.7       5      70 ..     224     287 ..     221     308 .. 0.79
   3 ?    3.0   0.0     0.045     1e+02       6      66 ..     261     325 ..     256     328 .. 0.54
   4 !    6.4   0.0     0.004       8.9       6      46 ..     346     387 ..     343     395 .. 0.73
   5 ?    5.1   0.0      0.01        23       8      31 ..     395     417 ..     388     420 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.72
    BBS2_Mid 14 eLvvgsddfeirvfke 29
                +++ gs d +irv++ 
  EFC37093.1 83 HILSGSCDGQIRVWDL 98
                5778888888888764 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0043
    BBS2_Mid   5 advdgdgeneLvvgsddfeirvfkeeelvaeitetekvvslarlekerfayaleNGtvgvyekker 70 
                  d  g+ +++L+ g +   i   k+e  +++ tet   v + ++ek+ +ay  +  tvg+y++++ 
  EFC37093.1 224 WDCSGHSSSSLIPGGTSRLI--CKQEYELSTSTETIYSVKFNKVEKNLIAYCARDRTVGLYDMRTN 287
                 56677777778888777766..4666667888999999***********************98764 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.045
    BBS2_Mid   6 dvdgdgeneLvvgsddfeirvfkee..elva..eitetekvvslarlekerfayaleNGtvgvye 66 
                 ++++ ++n +  ++ d ++ +++    ++++  +++++++ v+   +++ +f +a e G v  ++
  EFC37093.1 261 KFNKVEKNLIAYCARDRTVGLYDMRtnQMIRavTMQTKSNKVCWNPMNPFHFSAANEDGNVYTFD 325
                 45555555555566666666664321145441134444555555667777777777777766665 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.004
    BBS2_Mid   6 dvdgdge.neLvvgsddfeirvfkeeelvaeitetekvvsla 46 
                 dvd + + +e+v +  d ++r+fk ++   +++e  +   + 
  EFC37093.1 346 DVDYNPSgTEIVTAGYDKSVRIFKTDSTSYKAREVYHTKRMQ 387
                 5554433389****************9998888766555554 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.01
    BBS2_Mid   8 dgdgeneLvvgsddfeirvfkeee 31 
                  gd  +++  gsdd++ir++k+e+
  EFC37093.1 395 SGD-GRYIYSGSDDQSIRIWKNER 417
                 455.368899***********997 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.51   1.1e+03      55      79 ..      86     110 ..      81     118 .. 0.81
   2 !    9.6   0.0    0.0005       1.1      35      89 ..     251     304 ..     239     308 .. 0.77
   3 ?    1.9   0.0      0.12   2.7e+02      37      70 ..     340     373 ..     314     384 .. 0.82
   4 !    8.3   0.0    0.0012       2.7      11      70 ..     357     418 ..     347     438 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.51
  ANAPC4_WD40  55 vaysdgevrlldaesgkvvhslsvk 79 
                   +  dg++r+ d  + k++ +++ +
   EFC37093.1  86 SGSCDGQIRVWDLTERKTIYAIDRA 110
                  567799******9999999888755 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0005
  ANAPC4_WD40  35 dkedsevrsLaWkpdgk.lLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                  +++ +++ s+++++ +k l+a    d +v l+d+ + ++++++++++++  +++ W
   EFC37093.1 251 STSTETIYSVKFNKVEKnLIAYCARDRTVGLYDMRTNQMIRAVTMQTKS--NKVCW 304
                  567789999999987761556666788*****************99985..55555 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.12
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldaesg 70 
                  + + v ++ ++p+g+ ++ a  d +vr+++  s+
   EFC37093.1 340 HINAVLDVDYNPSGTEIVTAGYDKSVRIFKTDST 373
                  556788999*******************987665 PP

  == domain 4  score: 8.3 bits;  conditional E-value: 0.0012
  ANAPC4_WD40  11 AlatedgellvfRlng.....qrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesg 70 
                    a  d+++++f ++      ++v+++   k+ ++v  ++++ dg+ +  + +d ++r+ + e  
   EFC37093.1 357 VTAGYDKSVRIFKTDStsykaREVYHT---KRMQRVFTVKYSGDGRYIYSGSDDQSIRIWKNERS 418
                  555667777777776645444556666...9999*************************988765 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.8   3.9e+03      55      76 ..      83     104 ..      80     111 .. 0.63
   2 !   11.6   0.0   5.7e-05      0.13       2      68 ..     256     324 ..     255     335 .. 0.77
   3 ?    0.4   0.0      0.14   3.2e+02       3      33 ..     344     374 ..     342     380 .. 0.89
   4 ?    2.9   0.0     0.025        57       2      30 ..     388     416 ..     387     421 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.8
   WD40_like  55 lilvvtlDGtillslleneeev 76 
                 +il ++ DG+i   +l++ +++
  EFC37093.1  83 HILSGSCDGQIRVWDLTERKTI 104
                 4666677777766666655544 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 5.7e-05
   WD40_like   2 eiYsidisk.kgslilyGgkddkctvlkleslesvsivesfedSvifvkllddd.lilvvtlDGtills 68 
                  iYs+ ++k + +li+y ++d ++ ++++++++++  v+  + S   +    +  ++  +  DG++ + 
  EFC37093.1 256 TIYSVKFNKvEKNLIAYCARDRTVGLYDMRTNQMIRAVTMQTKSNKVCWNPMNPfHFSAANEDGNVYTF 324
                 69*****985678***********************999988886666443333256666666666555 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.14
   WD40_like   3 iYsidiskkgslilyGgkddkctvlklesle 33 
                 +  +d+++ g+ i+  g d+ ++++k++s  
  EFC37093.1 344 VLDVDYNPSGTEIVTAGYDKSVRIFKTDSTS 374
                 5679**********************99876 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.025
   WD40_like   2 eiYsidiskkgslilyGgkddkctvlkle 30 
                  ++++ +s +g +i  G++d+ +++ k e
  EFC37093.1 388 RVFTVKYSGDGRYIYSGSDDQSIRIWKNE 416
                 589*********************98865 PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0    0.0022       4.9     231     259 ..      82     110 ..      65     146 .. 0.81
   2 ?    4.0   0.0    0.0072        16     222     276 ..     261     309 ..     223     320 .. 0.82
   3 ?   -3.8   0.0       1.7   3.7e+03     229     246 ..     397     414 ..     366     434 .. 0.61

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0022
                 TEEEEEETT-EEEEEETTTTEEEEEEE-- CS
      Nup160 231 tylfalsrdgkLrvWnlltgkclatidll 259
                  ++++ s dg +rvW+l+  k+++ id  
  EFC37093.1  82 IHILSGSCDGQIRVWDLTERKTIYAIDRA 110
                 57888899***************999965 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.0072
                 ET.....TTTEEEEEETT-EEEEEETTTTEEEEEEE--.-SSSTTS--SSEESEE CS
      Nup160 222 avavveigqtylfalsrdgkLrvWnlltgkclatidllrdeeaqdessskstldp 276
                  +  v  ++++++   rd+++ + + +t++ ++  +++    ++++++++ +++p
  EFC37093.1 261 KFNKV--EKNLIAYCARDRTVGLYDMRTNQMIRAVTMQ----TKSNKVCWNPMNP 309
                 23233..89*****************************....9999999999988 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 1.7
                 TTTEEEEEETT-EEEEEE CS
      Nup160 229 gqtylfalsrdgkLrvWn 246
                 +  y+++ s d+ +r+W 
  EFC37093.1 397 DGRYIYSGSDDQSIRIWK 414
                 455666666666666663 PP

>> Spt5_N  Spt5 transcription elongation factor, acidic N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   7.6    0.0013       2.8      26      94 ..     438     504 ..     423     513 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0013
                 X.XXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..X-G CS
      Spt5_N  26 ddfiaeeeaeeeeed.serddrshreldrrrqaeededaeeiaealeeRYgrsskkayrgeaeessevpq 94 
                 ++ i++ ++ e+ ++ +++++  hr   ++++++++++aee  e+ +eR+ +++ +++++++++   +++
  EFC37093.1 438 QKLIERYKNVEDVRKiAAHRHLPHRIKTQSKEMQKEREAEERREKVRERFTKKKDDKKNSMSAK---IEK 504
                 4456666566666665666777788888888888889999999999999988666666655555...555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2179  (0.121535); expected 358.6 (0.02)
Passed bias filter:                      676  (0.0377043); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.80u 0.35s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 2949.31
//
Query:       EFC37094.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.012   15.1   0.0      0.015   14.8   0.0    1.1  1  Tab2_like  RNA-binding protein Tab2/Atab2


Domain annotation for each model (and alignments):
>> Tab2_like  RNA-binding protein Tab2/Atab2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0   8.4e-07     0.015      97     157 ..      95     154 ..      87     160 .] 0.79

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 8.4e-07
   Tab2_like  97 leereeevYpqeegyteqaaakeplaldkpppvpLPdalrgekwafvsLeaseleeakewe 157
                 l   ++++Y +++g ++++ +++  +  +++ ++L d++  ++w fv+L+ s l+e ++ +
  EFC37094.1  95 LPASAKDIYLRNHGNSSNP-SSSASSNPNRNTNKLDDEFFADNWYFVELHQSILQESTHSN 154
                 66678999*9999997777.4555556688889*********************9986655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       508  (0.028334); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 945.26
//
Query:       EFC37095.1  [L=398]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-22   78.7   1.0    4.7e-22   78.1   1.0    1.3  1  PWI       PWI domain


Domain annotation for each model (and alignments):
>> PWI  PWI domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.1   1.0   2.6e-26   4.7e-22       1      70 [.      42     111 ..      42     113 .. 0.95

  Alignments for each domain:
  == domain 1  score: 78.1 bits;  conditional E-value: 2.6e-26
         PWI   1 dvlkpWIakkitellgfeDdvvieyvlnlLeeekeldpkklqinltgfLek.eaekFvkeLWelllsaqss 70 
                 +v+  WI+k+i+el g++Dd+++ey+ +lL+e k +dpk++qi+l+gf+   +++ F+keLW+ll++aqs+
  EFC37095.1  42 EVFTLWIHKTIEELTGTDDDMIAEYANSLLME-KDCDPKQMQIQLAGFMTIdKSAIFMKELWKLLVEAQST 111
                 57889*************************76.69***************99*****************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (398 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1794  (0.100061); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.43
# Mc/sec: 2805.92
//
Query:       EFC37096.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.6e-09   36.5  10.9    8.2e-09   35.7  10.9    1.4  1  FA_desaturase  Fatty acid desaturase
  ------ inclusion threshold ------
       0.22   11.6   1.0       0.41   10.8   0.5    1.6  2  Nanovirus_C8   Nanovirus component 8 (C8) protein


Domain annotation for each model (and alignments):
>> FA_desaturase  Fatty acid desaturase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.7  10.9   9.1e-13   8.2e-09       6     235 ..      56     288 ..      49     297 .. 0.61

  Alignments for each domain:
  == domain 1  score: 35.7 bits;  conditional E-value: 9.1e-13
  FA_desaturase   6 llla.lllglfllgitg.slaHeaaHgalfkkrklnrwlndllgallglplgi..sysawrisH.lrHHaytngp.deDpdlaplal......... 86 
                    l+l+ l++     g ++    H+++H+     ++ln+++ dll   lg+ +g   +++  +i H  +HH + +g+  +  +   +a+         
     EFC37096.1  56 LPLVyLIC-----GGRWtLCYHNLLHQ----EKSLNPIV-DLL---LGVGFGHllTFKPGKIGHdSHHHFN-YGQdSRKYSMD-IAQdyltpsdil 136
                    33222333.....33344788999996....55599**9.666...55555555589999****6555544.44302222222.222466667777 PP

  FA_desaturase  87 ........srfeglfryllrlllgllvlgwllalvlglwlrrlarrrapsksrrrkwrllawlllllawlglwlalllllglalllwlvplllllf 174
                            +  +++ +  ++ + ++++ +    l+ + ++ ++ + +++         +  + + ++++++l++++ll +++a l+ lv+++l+++
     EFC37096.1 137 yrhkqimqRDADYWCKSSPNRWVLFMRSS----LFDFNYISFYLKKKRD-------MKWKHAPMTFARLVLLLAPFLLMNPIAYLIHLVMCRLVMT 221
                    66665553222222222333333222222....2222255555555554.......5566666666666999******999988744444444444 PP

  FA_desaturase 175 llalvlnyveHyg.....gdwgerqvetsasir.saswllnlltgnlnyHieHHlfPgvpwyrLpel 235
                    ++ +v++ + H         +   +++++ +i+     l ++ +++ n H +HH+fP+   + L ++
     EFC37096.1 222 VIFMVFTTLAHEEgwfdsLVDNFYPFQQTVDINlVLEILIGYHVHHVNEHDNHHIFPKRDVSMLEQI 288
                    4455556666666688887788888888888888899999999999999********9888877766 PP

>> Nanovirus_C8  Nanovirus component 8 (C8) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.5   4.5e-05      0.41      90     127 ..     105     142 ..      99     152 .. 0.85
   2 ?   -3.5   0.0       1.1   9.6e+03      25      54 ..     272     305 ..     267     312 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 4.5e-05
  Nanovirus_C8  90 gylyhddyyyyegkkkveldiesdylkpdidfskdlev 127
                   g+  h+ + y +  +k+ +di  dyl+p    +++ ++
    EFC37096.1 105 GHDSHHHFNYGQDSRKYSMDIAQDYLTPSDILYRHKQI 142
                   5677999*********************8877776555 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.1
  Nanovirus_C8  25 dnrqdvfcvd.sgagkks.prkv..llvsievvf 54 
                   dn+  ++  d s+  + s pr++  l+  +++ f
    EFC37096.1 272 DNHHIFPKRDvSMLEQISiPRRMvnLFANCFTKF 305
                   5566666655466777777777523456676666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       846  (0.0471861); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.24s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2289.19
//
Query:       EFC37097.1  [L=281]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-28   98.9   0.2    8.8e-11   42.3   0.0    3.2  3  Ank_2     Ankyrin repeats (3 copies)
    2.8e-19   69.2   0.3    4.5e-06   27.1   0.0    4.7  4  Ank_4     Ankyrin repeats (many copies)
      1e-18   65.5   1.4       0.01   16.3   0.0    6.2  6  Ank_3     Ankyrin repeat
    7.8e-17   60.9   0.2      0.023   15.1   0.0    6.0  6  Ank       Ankyrin repeat
    1.7e-14   53.7   0.3     0.0031   17.8   0.0    5.1  5  Ank_5     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.067   12.8   0.0        0.1   12.2   0.0    1.4  1  Dip       gp37/Dip protein
        2.1    8.4   6.1          2    8.5   0.4    3.3  4  DUF3447   Domain of unknown function (DUF3447)


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.8   0.1   3.5e-12   9.1e-09       2      80 ..       4      99 ..       3     102 .. 0.78
   2 !   24.8   0.0   9.8e-09   2.5e-05       4      49 ..      77     142 ..      76     159 .. 0.68
   3 !   42.3   0.0   3.4e-14   8.8e-11      27      80 ..     173     230 ..     145     233 .. 0.82

  Alignments for each domain:
  == domain 1  score: 35.8 bits;  conditional E-value: 3.5e-12
       Ank_2  2 hlAakngnlelvklLleg...adpn.k.ngktaLhyAakngnleivklLleh.....ad.....ndgr.tpLhyAarsghleivklLlek.gadin 80
                  A++ng+ + v+l+l+g   +d+n +    ++L++A+k gn+ iv+lLl+      ++     ++ + + L++A   g  +ivklLl   g+++n
  EFC37097.1  4 NKACMNGDVSQVQLILSGdevVDINdQySYSSPLYAACKLGNIAIVELLLATgrrvnINkgvhcYTDYcSNLFAAYTRGFRDIVKLLLTIdGINVN 99
                679****999******554558899646779*******************956664522455564444488****999*99*******43488777 PP

  == domain 2  score: 24.8 bits;  conditional E-value: 9.8e-09
       Ank_2   4 Aakn.gnlelvklLl..egadpn......k.......ngktaLhyAakngnleivklLleh....a 49 
                 Aa+  g  ++vklLl   g ++n      +       +  ++L+yA+k g+ e+vk+Ll++    +
  EFC37097.1  77 AAYTrGFRDIVKLLLtiDGINVNdgcylmStsfqhydKQDFPLYYACKIGDYEMVKWLLKFedieV 142
                 777447558999999886666555544431445566677999999999999999999998655442 PP

  == domain 3  score: 42.3 bits;  conditional E-value: 3.4e-14
       Ank_2  27 ktaLhyAakngnleivklLleh....adndgr.tpLhyAarsghleivklLlekgadin 80 
                  t+L++A+k+g+leivklLl++    + n+g+ +pL++A+  +++ei++ Ll++ga ++
  EFC37097.1 173 TTPLYAACKRGYLEIVKLLLQFrnisV-NEGEvSPLYAAIMGNYIEIIECLLYNGALVD 230
                 7*******************9856544.55665*******999*********9998665 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   1.6e-06    0.0041       7      55 .]       5      53 ..       1      53 [. 0.88
   2 ?    0.0   0.0      0.55   1.4e+03      41      55 .]      76      91 ..      70      91 .. 0.81
   3 !   17.9   0.0   1.4e-06    0.0035      38      55 .]     118     135 ..     103     135 .. 0.93
   4 !   27.1   0.0   1.8e-09   4.5e-06       2      55 .]     173     223 ..     171     223 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 1.6e-06
       Ank_4  7 yaaisgrlelvrlLl..ekgadinaqdnrsGetalhiAakrgnveilklLl 55
                +a++ g++  v+l+l  +  +din q   s  ++l+ A+k gn+ i++lLl
  EFC37097.1  5 KACMNGDVSQVQLILsgDEVVDINDQ--YSYSSPLYAACKLGNIAIVELLL 53
                79*************43335*****9..88889*****************8 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.55
       Ank_4 41 iAa.krgnveilklLl 55
                +Aa  rg+ +i+klLl
  EFC37097.1 76 FAAyTRGFRDIVKLLL 91
                4553788*******98 PP

  == domain 3  score: 17.9 bits;  conditional E-value: 1.4e-06
       Ank_4  38 alhiAakrgnveilklLl 55 
                 +l++A+k+g++e++k+Ll
  EFC37097.1 118 PLYYACKIGDYEMVKWLL 135
                 9****************8 PP

  == domain 4  score: 27.1 bits;  conditional E-value: 1.8e-09
       Ank_4   2 ltaLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55 
                 +t+L +a++ g le+v+lLl++ ++++    n+   ++l+ A++++++ei++ Ll
  EFC37097.1 173 TTPLYAACKRGYLEIVKLLLQFrNISV----NEGEVSPLYAAIMGNYIEIIECLL 223
                 689******************956774....66677****************997 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.23   5.9e+02       6      23 ..       3      20 ..       2      28 .. 0.77
   2 !   12.9   0.0     5e-05      0.13       3      29 ..      34      61 ..      32      63 .. 0.82
   3 !    7.1   0.0    0.0038       9.9       7      30 ..      76      99 ..      71     100 .. 0.86
   4 !   16.3   0.0   3.9e-06      0.01       5      29 ..     118     142 ..     115     144 .. 0.86
   5 !   14.3   0.0   1.7e-05     0.044       4      30 ..     174     200 ..     173     201 .. 0.95
   6 !    5.9   0.1    0.0094        24       5      29 ..     206     229 ..     204     231 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.23
       Ank_3  6 LhlAarsgnleivkfLle 23
                L  A+++g+++ v+++l 
  EFC37097.1  3 LNKACMNGDVSQVQLILS 20
                789*****9954777776 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 5e-05
       Ank_3  3 etpLhlAarsgnleivkfLle.nkgadv 29
                 +pL+ A++ gn++iv++Ll   + +++
  EFC37097.1 34 SSPLYAACKLGNIAIVELLLAtGRRVNI 61
                59******************95555555 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0038
       Ank_3  7 hlAarsgnleivkfLlenkgadvn 30
                + A   g  +ivk+Ll + g++vn
  EFC37097.1 76 FAAYTRGFRDIVKLLLTIDGINVN 99
                5567778889*************9 PP

  == domain 4  score: 16.3 bits;  conditional E-value: 3.9e-06
       Ank_3   5 pLhlAarsgnleivkfLlenkgadv 29 
                 pL++A++ g++e+vk+Ll+   ++v
  EFC37097.1 118 PLYYACKIGDYEMVKWLLKFEDIEV 142
                 9*****************9555555 PP

  == domain 5  score: 14.3 bits;  conditional E-value: 1.7e-05
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 tpL+ A++ g leivk+Ll+ +++ vn
  EFC37097.1 174 TPLYAACKRGYLEIVKLLLQFRNISVN 200
                 9*******************9999998 PP

  == domain 6  score: 5.9 bits;  conditional E-value: 0.0094
       Ank_3   5 pLhlAarsgnleivkfLlenkgadv 29 
                 pL+ A++ + +ei++ Ll  +ga v
  EFC37097.1 206 PLYAAIMGNYIEIIECLLY-NGALV 229
                 6665555555589***999.78755 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.29   7.3e+02       9      28 ..       6      28 ..       3      30 .. 0.77
   2 !   11.2   0.0   0.00016       0.4       4      28 ..      35      62 ..      34      64 .. 0.86
   3 !    6.1   0.0    0.0066        17      10      28 ..      78      99 ..      66     101 .. 0.76
   4 !   10.0   0.0   0.00037      0.94       5      22 ..     118     135 ..     116     145 .. 0.85
   5 !   15.1   0.0   8.9e-06     0.023       4      24 ..     174     195 ..     171     201 .. 0.83
   6 !    9.0   0.0   0.00078         2       4      25 ..     205     227 ..     203     232 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.29
                HHHHTTHHHHHHHHTT...TSTT CS
         Ank  9 AatngkkriiklLLhG...Anln 28
                A++ng+++ ++l+L+G    ++n
  EFC37097.1  6 ACMNGDVSQVQLILSGdevVDIN 28
                899999999**988884444555 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00016
                BHHHHHHHHTTHHHHHHHH.TT..TSTT CS
         Ank  4 TPLHlAatngkkriiklLL.hG..Anln 28
                +PL  A+  g+  i++lLL  G   n+n
  EFC37097.1 35 SPLYAACKLGNIAIVELLLaTGrrVNIN 62
                69*****999999******877667877 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0066
                H.HHTTHHHHHHHH..TTTSTT CS
         Ank 10 a.tngkkriiklLL..hGAnln 28
                a t+g  +i+klLL  +G n+n
  EFC37097.1 78 AyTRGFRDIVKLLLtiDGINVN 99
                35445556******988*9998 PP

  == domain 4  score: 10.0 bits;  conditional E-value: 0.00037
                 HHHHHHHHTTHHHHHHHH CS
         Ank   5 PLHlAatngkkriiklLL 22 
                 PL +A+ +g+ +++k+LL
  EFC37097.1 118 PLYYACKIGDYEMVKWLL 135
                 9****************9 PP

  == domain 5  score: 15.1 bits;  conditional E-value: 8.9e-06
                 BHHHHHHHHTTHHHHHHHH.TT CS
         Ank   4 TPLHlAatngkkriiklLL.hG 24 
                 TPL  A+ +g ++i+klLL  +
  EFC37097.1 174 TPLYAACKRGYLEIVKLLLqFR 195
                 *******************434 PP

  == domain 6  score: 9.0 bits;  conditional E-value: 0.00078
                 BHHHHHHHHTTHHHHHHHH.TTT CS
         Ank   4 TPLHlAatngkkriiklLL.hGA 25 
                 +PL  A++++  +ii+ LL +GA
  EFC37097.1 205 SPLYAAIMGNYIEIIECLLyNGA 227
                 8******9888********8898 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   1.3e-05     0.034       6      43 ..      24      62 ..      17      63 .. 0.79
   2 ?    0.8   0.0      0.27   6.8e+02      22      36 ..      76      91 ..      76     104 .. 0.80
   3 !   10.8   0.0   0.00019      0.49      18      37 ..     117     136 ..     110     145 .. 0.87
   4 !   17.8   0.0   1.2e-06    0.0031      13      43 ..     169     196 ..     162     207 .. 0.77
   5 ?    3.9   0.0     0.027        70      12      44 ..     199     231 ..     193     237 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.3e-05
       Ank_5  6 padvnrldgggntpLhvAakygaadvvrlLl..argadln 43
                 +d+n++  ++ +pL  A+k g+  +v+lLl   r++++n
  EFC37097.1 24 VVDINDQYSYS-SPLYAACKLGNIAIVELLLatGRRVNIN 62
                35566666665.*******************888888776 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.27
       Ank_5 22 vAak.ygaadvvrlLl 36
                +Aa+ +g  d+v+lLl
  EFC37097.1 76 FAAYtRGFRDIVKLLL 91
                589999999******9 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 0.00019
       Ank_5  18 tpLhvAakygaadvvrlLla 37 
                  pL +A+k g  ++v++Ll+
  EFC37097.1 117 FPLYYACKIGDYEMVKWLLK 136
                 79*****************4 PP

  == domain 4  score: 17.8 bits;  conditional E-value: 1.2e-06
       Ank_5  13 dgggntpLhvAakygaadvvrlLlargadln 43 
                  ++ +tpL  A+k+g++++v+lLl   + +n
  EFC37097.1 169 YPYLTTPLYAACKRGYLEIVKLLL---QFRN 196
                 46678*******************...4444 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.027
       Ank_5  12 ldgggntpLhvAakygaadvvrlLlargadlnl 44 
                  ++g ++pL  A+ +++ ++++ Ll +ga  + 
  EFC37097.1 199 VNEGEVSPLYAAIMGNYIEIIECLLYNGALVDE 231
                 5778889****************9966666555 PP

>> Dip  gp37/Dip protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0     4e-05       0.1     129     206 ..      17      95 ..       6     130 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 4e-05
                 EEEET--GGGTHHHHHHHSSEEE---TTSHHHHHHHSHHHHHHHHHHHHHHHHHHHHHTS-.-SS----EEEEEE-SSE CS
         Dip 129 efmpgvhvddisdkliksssyqgifktdnleefeflvdkknannvkelilaytdyfankla.fkdpaepavemyqfidr 206
                  ++ g  v di+d+   ss      k  n+  +e+l+      n+++ + +ytdy +n +a +       v++   id 
  EFC37097.1  17 LILSGDEVVDINDQYSYSSPLYAACKLGNIAIVELLLATGRRVNINKGVHCYTDYCSNLFAaYTRGFRDIVKLLLTIDG 95 
                 4678999**************************************************9875244555556666666655 PP

>> DUF3447  Domain of unknown function (DUF3447)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.76   1.9e+03      39      54 ..      40      55 ..      28      80 .. 0.55
   2 ?    0.7   0.1       0.2   5.2e+02      34      59 ..     117     142 ..      77     160 .. 0.72
   3 ?   -1.5   0.0      0.99   2.5e+03      10      31 ..     176     197 ..     174     204 .. 0.82
   4 ?    8.5   0.4   0.00076         2      10      51 ..     207     248 ..     199     264 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.76
     DUF3447 39 aiisHnidfvtyLmne 54
                a +  ni +v+ L+  
  EFC37097.1 40 ACKLGNIAIVELLLAT 55
                4444455555555443 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.2
     DUF3447  34 kcmeyaiisHnidfvtyLmneynlei 59 
                   + ya +   +++v++L++  ++e+
  EFC37097.1 117 FPLYYACKIGDYEMVKWLLKFEDIEV 142
                 34667777778888888877435554 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.99
     DUF3447  10 lelsflggnpeIineClkyqkp 31 
                 l+ ++  g  eI++  l+++++
  EFC37097.1 176 LYAACKRGYLEIVKLLLQFRNI 197
                 6778889999999999998776 PP

  == domain 4  score: 8.5 bits;  conditional E-value: 0.00076
     DUF3447  10 lelsflggnpeIineClkyq..kpdkkcmeyaiisHnidfvtyL 51 
                 l+ +++g+  eIi eCl y+   +d+kc e a +   id+ + L
  EFC37097.1 207 LYAAIMGNYIEII-ECLLYNgaLVDEKCEE-AAQEMDIDIESIL 248
                 789**********.6988876678888855.4455556655555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (281 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       403  (0.0224776); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1811.97
//
Query:       EFC37098.1  [L=417]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.033   14.1   0.3       0.13   12.2   0.0    2.1  2  DUF4957   Domain of unknown function (DUF4957)


Domain annotation for each model (and alignments):
>> DUF4957  Domain of unknown function (DUF4957)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   7.2e-06      0.13      35     138 ..     188     281 ..     151     282 .. 0.69
   2 ?   -0.9   0.0     0.078   1.4e+03      59      98 ..     299     356 ..     283     361 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 7.2e-06
     DUF4957  35 asistgasLkiknldldgsasdssfialsetpdeti........kdtltiqnCeikdvnkgliydnnkkyviesivinncl.vkniessggdiidfkkg 124
                 +si+     + +++++  s++d++          ++        ++++ i+ C ++d+++ ++  ++    +  i+i++ + v+n e ++++     +g
  EFC37098.1 188 VSINH----HYDQVKFAISQNDDQ----------FLichsasqyYGPFYISLCSFRDLENMFMDEEV---RVGLISIEEPIlVENSEIQSKMAAPISDG 269
                 33333....445666666665555..........43444444446***************9997776...88888888765255566667777777777 PP

     DUF4957 125 finnltvknSTiyn 138
                   n++ +  ST+y 
  EFC37098.1 270 --NKVALYGSTFYD 281
                 ..888888888885 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.078
     DUF4957  59 fialsetpdeti..................kdtltiqnCeikdvnkgliydnnkkyvi 98 
                 fi++++ +++ i                    + ++ +C+i d + +l+ +++ ++++
  EFC37098.1 299 FIQFEYPENSYIleipphlrefkskqqllvSTSGSFYKCNIVDRKTKLLKCSKSAIIM 356
                 5555555444445555555555554333333444567899999999998888865554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (417 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.43
# Mc/sec: 2883.61
//
Query:       EFC37099.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1695.03
//
Query:       EFC37100.1  [L=182]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-24   82.7  10.7    1.4e-05   24.7   0.0    6.5  6  LRR_6     Leucine Rich repeat
    6.1e-16   57.9   9.0    2.5e-06   27.1   0.3    3.4  3  LRR_8     Leucine rich repeat
    1.7e-12   47.3  19.8    0.00071   19.9   7.6    5.2  5  LRR_4     Leucine Rich repeats (2 copies)
    3.7e-05   23.7  10.0        5.1    8.0   0.0    6.2  6  LRR_1     Leucine Rich Repeat
    0.00013   21.6   2.3       0.16   11.5   0.0    2.7  3  LRR_9     Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0   0.00031       1.1       5      24 .]       4      23 ..       2      23 .. 0.91
   2 !   24.7   0.0     4e-09   1.4e-05       3      24 .]      27      48 ..      25      48 .. 0.92
   3 ?    4.7   0.1      0.01        36       5      21 ..      77      93 ..      73      93 .. 0.90
   4 !   16.3   0.0     2e-06    0.0071       5      24 .]     101     120 ..      98     120 .. 0.92
   5 !   20.1   0.2   1.2e-07   0.00043       4      24 .]     124     144 ..     121     144 .. 0.94
   6 !    9.0   0.3   0.00043       1.6       2      18 ..     148     165 ..     147     165 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00031
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+LdL+  +I+ + ae ++
  EFC37100.1  4 LTHLDLRNTGITKKSAELIS 23
                9************9999885 PP

  == domain 2  score: 24.7 bits;  conditional E-value: 4e-09
       LRR_6  3 thLteLdLsgNdIgDeGaeaLa 24
                ++Lt+L++s+NdI +eGa+ L+
  EFC37100.1 27 PKLTYLNISYNDIRNEGAKYLS 48
                79****************9886 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.01
       LRR_6  5 LteLdLsgNdIgDeGae 21
                Lt+L+++ N +g eG++
  EFC37100.1 77 LTKLNVNTNLFGVEGCK 93
                9*************975 PP

  == domain 4  score: 16.3 bits;  conditional E-value: 2e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+eL ++ NdIgDeG++ L+
  EFC37100.1 101 LKELWINENDIGDEGVKYLC 120
                 89999************998 PP

  == domain 5  score: 20.1 bits;  conditional E-value: 1.2e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L+L  N+Ig eG+++L+
  EFC37100.1 124 SLTSLHLEENNIGVEGVKSLC 144
                 8*******************8 PP

  == domain 6  score: 9.0 bits;  conditional E-value: 0.00043
       LRR_6   2 nthLteLdLsgNd.IgDe 18 
                  +hL +L++++N+ I D+
  EFC37100.1 148 LSHLATLEIRDNQlIEDD 165
                 68***********99885 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.3   7.1e-10   2.5e-06       2      55 ..       3      57 ..       2      58 .. 0.96
   2 !   21.0   0.8   5.8e-08   0.00021       2      61 .]      76     135 ..      67     135 .. 0.98
   3 !   14.0   0.1   8.7e-06     0.031      23      57 ..     147     181 ..     137     182 .] 0.73

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 7.1e-10
                T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLd 55
                +Lt LdL+n+ +t+ + e  ++ l++L++L++s+N ++   ++ +s +++L+ L 
  EFC37100.1  3 QLTHLDLRNTGITKKSAELISNeLPKLTYLNISYNDIRNEGAKYLSEMKQLTALE 57
                79*************************************************9996 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 5.8e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+++ N + + + +  +g+++Lk+L +++N +     + +  L+sL+sL+L+ N++
  EFC37100.1  76 QLTKLNVNTNLFGVEGCKIVSGMKQLKELWINENDIGDEGVKYLCELKSLTSLHLEENNI 135
                 79********************************************************97 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 8.7e-06
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 +ls+L +L++++N+l   + + f+++p+L  L L+
  EFC37100.1 147 NLSHLATLEIRDNQLIEDDYQLFESMPQLIDLSLE 181
                 67777777777777777777777777777777665 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   7.6     2e-07   0.00071       1      39 [.       2      39 ..       2      88 .. 0.91
   2 !   14.4   0.4   1.1e-05      0.04       1      39 [.      75     111 ..      75     117 .. 0.81
   3 !   17.0   0.9   1.6e-06    0.0059       1      34 [.      99     134 ..      99     145 .. 0.86
   4 !   11.6   1.0   7.9e-05      0.28       1      38 [.     123     164 ..     123     170 .. 0.75
   5 !    6.2   0.1    0.0041        15       3      30 ..     151     180 ..     149     181 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 2e-07
                SS--EEE--SS---E-S-..HHH.-TT--EEE-.-S-----G CS
       LRR_4  1 pnLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitdl 39
                ++L++LdL+n+ +t+ +   +++ lp+L++L++s N    d+
  EFC37100.1  2 KQLTHLDLRNTGITKKSAelISNeLPKLTYLNISYN----DI 39
                58************7555664466************....77 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.1e-05
                 SS--EEE--SS---E-S-HH...H-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpnLkeLdLsgNnlitdl 39 
                 ++L++L+ + ++l  +++++   ++++LkeL++++N    d+
  EFC37100.1  75 KQLTKLNVN-TNLFGVEGCKivsGMKQLKELWINEN----DI 111
                 579999999.55888999555546*********999....77 PP

  == domain 3  score: 17.0 bits;  conditional E-value: 1.6e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++L+++ N + d +   l  l++L++L+L +Nn
  EFC37100.1  99 KQLKELWINENDIGDEGVkyLCELKSLTSLHLEENN 134
                 58*************99988445*********8883 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 7.9e-05
                 SS--EEE--SS---E-S-....HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl....leklpnLkeLdLsgNnlitd 38 
                 ++L++L+L  N++   +      ++l +L +L + +N li+d
  EFC37100.1 123 KSLTSLHLEENNIGVEGVkslcSANLSHLATLEIRDNQLIED 164
                 68*******8888855556654337*********77766655 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.0041
                 --EEE--SS-.--.E-S-HHH-TT--EEE- CS
       LRR_4   3 LevLdLsnNq.lt.diplleklpnLkeLdL 30 
                 L +L +++Nq +  d +l+e++p+L  L+L
  EFC37100.1 151 LATLEIRDNQlIEdDYQLFESMPQLIDLSL 180
                 66899999963777777799*****99998 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.1    0.0082        29       1      18 [.       3      20 ..       3      26 .. 0.74
   2 !    8.0   0.0    0.0014       5.1       1      18 [.      28      45 ..      28      54 .. 0.80
   3 ?   -3.8   0.0         5   1.8e+04       4       9 ..      62      67 ..      62      69 .. 0.74
   4 ?    0.1   0.0      0.59   2.1e+03       2      12 ..      77      87 ..      76      97 .. 0.68
   5 ?    3.6   0.0      0.04   1.4e+02       1      22 [.     100     121 ..     100     122 .. 0.84
   6 ?    4.9   0.7     0.016        56       1      21 [.     124     144 ..     124     181 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0082
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L+hLdL+n  ++ ++++
  EFC37100.1  3 QLTHLDLRNTGITKKSAE 20
                59******9988655554 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0014
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++L++s+n + + ++ 
  EFC37100.1 28 KLTYLNISYNDIRNEGAK 45
                79********99666555 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 5
       LRR_1  4 hLdLsn 9 
                +Ld+++
  EFC37100.1 62 YLDIEG 67
                689876 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.59
       LRR_1  2 LrhLdLsnnpl 12
                L++L+++ n +
  EFC37100.1 77 LTKLNVNTNLF 87
                89999866654 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.04
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L ++ n +++ +  +++ 
  EFC37100.1 100 QLKELWINENDIGDEGVKYLCE 121
                 59*********99888887775 PP

  == domain 6  score: 4.9 bits;  conditional E-value: 0.016
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L+L+ n+++  +  s++
  EFC37100.1 124 SLTSLHLEENNIGVEGVKSLC 144
                 588999988888666666655 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.1   0.00045       1.6      63     120 ..       1      58 [.       1      63 [. 0.85
   2 !   11.5   0.0   4.5e-05      0.16      54     125 ..      65     135 ..      59     141 .. 0.81
   3 ?    0.3   0.0      0.12   4.3e+02      63      93 ..     148     178 ..     140     181 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00045
       LRR_9  63 lkrlktlllnnnrivriaeg.leevlPnleelvltnnelqeladldPlaslkklellsl 120
                 +k+l  l l n  i++ + + +++ lP+l+ l ++ n +++ +  + l ++k+l+ l +
  EFC37100.1   1 MKQLTHLDLRNTGITKKSAElISNELPKLTYLNISYNDIRNEGA-KYLSEMKQLTALEV 58 
                 6789999999999998765516899**************99887.89999999999865 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 4.5e-05
       LRR_9  54 irkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 i  l  +  lk+l  l +n n     + ++   + +l+el +++n + + + ++ l +lk+l++l l +n +
  EFC37100.1  65 IEGLSYLTELKQLTKLNVNTNLFGVEGCKIVSGMKQLKELWINENDIGDEG-VKYLCELKSLTSLHLEENNI 135
                 444455555666667788999888888889999999************976.69***********9998876 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.12
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleel 93 
                 l  l tl + +n+++    +l e++P+l  l
  EFC37100.1 148 LSHLATLEIRDNQLIEDDYQLFESMPQLIDL 178
                 5677888888888888888888888888766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       366  (0.0204139); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1167.61
//
Query:       EFC37101.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-16   59.0   0.2    0.00016   21.5   0.0    4.1  4  LRR_6     Leucine Rich repeat
    5.1e-12   45.4   1.7    1.6e-07   31.0   0.1    2.8  3  LRR_8     Leucine rich repeat
    5.5e-08   33.0   3.5    9.5e-05   22.7   0.0    3.4  4  LRR_4     Leucine Rich repeats (2 copies)
    1.7e-05   24.7   1.5        1.2   10.0   0.0    4.7  3  LRR_1     Leucine Rich Repeat
     0.0033   17.2   2.5     0.0099   15.7   1.9    1.8  2  FTH       FTH domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.59   2.1e+03       7      16 ..      29      38 ..      27      38 .. 0.84
   2 !   11.5   0.0   6.7e-05      0.24       5      23 ..      78      96 ..      76      97 .. 0.90
   3 !   21.5   0.0   4.3e-08   0.00016       3      23 ..     100     120 ..      98     121 .. 0.89
   4 !   20.8   0.0   7.2e-08   0.00026       5      23 ..     126     144 ..     125     145 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.59
       LRR_6  7 eLdLsgNdIg 16
                +L++ +N+I+
  EFC37101.1 29 KLSIDFNKIQ 38
                59999**995 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 6.7e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                L++Ld+++ +Ig +Ga  +
  EFC37101.1 78 LKSLDITSSEIGTAGARFI 96
                9**************9766 PP

  == domain 3  score: 21.5 bits;  conditional E-value: 4.3e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  hLt+Ld+ +N+Ig eGa  +
  EFC37101.1 100 KHLTKLDIDFNNIGAEGAVFI 120
                 6****************9765 PP

  == domain 4  score: 20.8 bits;  conditional E-value: 7.2e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+sgN+I +eG+  +
  EFC37101.1 126 LTYLDISGNNIRGEGVRYI 144
                 9**************9876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.22     8e+02       5      16 ..      29      40 ..      27      53 .. 0.79
   2 !   20.2   0.2     1e-07   0.00037       8      61 .]      61     112 ..      56     112 .. 0.74
   3 !   31.0   0.1   4.5e-11   1.6e-07       2      61 .]      77     136 ..      76     136 .. 0.97

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.22
                EEE-TTS--SEE CS
       LRR_8  5 sLdLsnNrltsl 16
                +L++++N+++  
  EFC37101.1 29 KLSIDFNKIQFN 40
                688888888765 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 1e-07
                 -TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   8 LsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++  ++t+l   + +  ++Lk+Ld+++ ++ t  ++ +s+L++L++Ld++ N++
  EFC37101.1  61 IDYKNITELTNITQF--EQLKSLDITSSEIGTAGARFISQLKHLTKLDIDFNNI 112
                 555555555554444..7888889999999998888888999999998888886 PP

  == domain 3  score: 31.0 bits;  conditional E-value: 4.5e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+sLd++++ +   +  + ++l++L+ Ld+  N++    +  +  + +L++Ld+sgN++
  EFC37101.1  77 QLKSLDITSSEIGTAGARFISQLKHLTKLDIDFNNIGAEGAVFIGKMDQLTYLDISGNNI 136
                 7**************************************999999*************98 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.58   2.1e+03       5      17 ..      29      41 ..      26      54 .. 0.66
   2 !    9.1   0.1   0.00051       1.8      11      32 ..      64      85 ..      56      91 .. 0.80
   3 !    9.1   0.0    0.0005       1.8      19      36 ..      96     112 ..      88     115 .. 0.78
   4 !   22.7   0.0   2.6e-08   9.5e-05       1      34 [.     100     135 ..     100     139 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.58
                EEE--SS---E-S CS
       LRR_4  5 vLdLsnNqltdip 17
                +L++  N+++  +
  EFC37101.1 29 KLSIDFNKIQFND 41
                5556666666544 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00051
                S---E-S-HHH-TT--EEE-.- CS
       LRR_4 11 NqltdiplleklpnLkeLdLsg 32
                 ++t++ ++ ++ +Lk+Ld+++
  EFC37101.1 64 KNITELTNITQFEQLKSLDITS 85
                57******99**********44 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.0005
                 HHH-TT--EEE-.-S--- CS
       LRR_4  19 leklpnLkeLdLsgNnli 36 
                 +++l++L++Ld+ +N +i
  EFC37101.1  96 ISQLKHLTKLDIDFN-NI 112
                 456*********667.44 PP

  == domain 4  score: 22.7 bits;  conditional E-value: 2.6e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++Ld+  N++   +   ++k+++L++Ld+sgNn
  EFC37101.1 100 KHLTKLDIDFNNIGAEGAvfIGKMDQLTYLDISGNN 135
                 68************777785557************5 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.3      0.15   5.5e+02       4      19 ..       7      22 ..       4      55 .. 0.78
   2 ?    5.5   0.0      0.01        36       1      10 [.     101     110 ..      77     122 .. 0.59
   3 !   10.0   0.0   0.00032       1.2       1      20 [.     125     144 ..     125     147 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.15
       LRR_1  4 hLdLsnnpllglppns 19
                h+ +s ++l++++ n 
  EFC37101.1  7 HIIISKCSLISKEWNE 22
                5668888887666554 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnn 10 
                 +L++Ld+  n
  EFC37101.1 101 HLTKLDIDFN 110
                 3455555555 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00032
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+s+n++ g + +++
  EFC37101.1 125 QLTYLDISGNNIRGEGVRYI 144
                 59*********988887776 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.5     0.088   3.2e+02     105     124 ..      35      57 ..      17      67 .. 0.62
   2 !   15.7   1.9   2.8e-06    0.0099      53     109 ..      61     120 ..      31     127 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.088
         FTH 105 daikirdi...llksstFqscei 124
                 + i++ d+   l+++s+F++c +
  EFC37101.1  35 NKIQFNDQklhLMSKSKFKNCVV 57 
                 33444444555899999999987 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 2.8e-06
         FTH  53 eeeeefeelveleQWKnAkklkiessklssf...piehlfhFeefeikldkfsvedaiki 109
                  +++++ el++  Q+ + k+l+i+ss+  +     i +l h+++++i+++++ +e a+ i
  EFC37101.1  61 IDYKNITELTNITQFEQLKSLDITSSEIGTAgarFISQLKHLTKLDIDFNNIGAEGAVFI 120
                 4566677777777777777777777777555566*****************999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       674  (0.0375927); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1015.65
//
Query:       EFC37102.1  [L=2273]
Description: hypothetical protein NAEGRDRAFT_59848 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.5e-30  104.5   0.0    1.1e-29  103.2   0.0    1.7  1  bMG10            Bacterial Alpha-2-macroglobulin MG10 domain
    3.9e-15   56.4   0.5    3.9e-15   56.4   0.5    3.1  3  A2M_BRD          Alpha-2-macroglobulin bait region domain
    2.4e-13   50.4   0.0    1.2e-10   41.7   0.0    4.1  3  MG2              MG2 domain
    1.3e-11   44.2   0.0    6.6e-11   41.9   0.0    2.3  2  A2M              Alpha-2-macroglobulin family
    3.4e-07   30.9   3.7       0.07   13.8   0.0    4.2  3  Big_5            Bacterial Ig-like domain
     0.0024   17.9   3.6      0.028   14.5   0.0    3.9  4  bMG3             Bacterial alpha-2-macroglobulin MG3 domain
  ------ inclusion threshold ------
      0.016   14.8   1.3      0.063   12.8   0.5    2.2  2  ZirS_C           Zinc-regulated secreted antivirulence protei
      0.027   14.7   1.8       0.14   12.5   0.2    2.8  3  DUF11            Domain of unknown function DUF11
      0.049   12.9   0.2       0.33   10.3   0.1    2.3  2  PurA             PurA ssDNA and RNA-binding protein
       0.14   12.4   6.0         13    6.0   0.0    5.1  5  MG4              Macroglobulin domain MG4
       0.15   12.4   0.3          1    9.7   0.1    2.6  2  DUF4198          Domain of unknown function (DUF4198)
       0.17   12.2   4.0        1.6    9.1   0.5    3.5  3  CarboxypepD_reg  Carboxypeptidase regulatory-like domain
       0.31   11.1  10.5       0.64   10.1   0.1    5.2  5  Big_1            Bacterial Ig-like domain (group 1)


Domain annotation for each model (and alignments):
>> bMG10  Bacterial Alpha-2-macroglobulin MG10 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.2   0.0   8.1e-33   1.1e-29       1     130 []    2117    2257 ..    2117    2257 .. 0.93

  Alignments for each domain:
  == domain 1  score: 103.2 bits;  conditional E-value: 8.1e-33
       bMG10    1 GlsveReyeklegkevsksda.....klkvGdkvrvrltvttprdleyvaledplPAGlepvnpslgtesesaeeye......wleeltefsyreir 86  
                  G+s++R ye   + +  k d+     k+k+G++vrv++t+  p+++++val+d+lPAGle+vnp+  t+ ++  +        +  + ++f++++ir
  EFC37102.1 2117 GFSISRVYEAITNPDDVKFDKntktwKVKSGELVRVNITICNPTRRYNVALVDKLPAGLEVVNPEIDTQLTNFGNGGnenelaNNHYFKWFENQNIR 2213
                  9*********99999999988999999*************************************9988866544443678899888899******** PP

       bMG10   87 ddrvvffadylpkgtytfeylvravtpGtfsvppakaeemYaPE 130 
                  d+rv++fa+ l +gt++++y +ra+t G+f +p +  eemY PE
  EFC37102.1 2214 DERVEAFARILYEGTHVYSYICRATTLGSFVAPSTYMEEMYSPE 2257
                  *******************************************9 PP

>> A2M_BRD  Alpha-2-macroglobulin bait region domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1         3   4.2e+03      28      69 ..     124     181 ..      98     183 .. 0.52
   2 ?   -1.2   0.1       1.7   2.4e+03      29      71 ..     807     892 ..     761     926 .. 0.55
   3 !   56.4   0.5   2.9e-18   3.9e-15       5     140 .]    1170    1322 ..    1166    1322 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3
                 -TT-....BSS-----.-S..................S........-EEEEEE--TT---- CS
                 xxxxxxxxxxxxxxxxxxxxx...............xx....xxxxxxxxxxxxxxxxxxx RF
     A2M_BRD  28 erdstlylvlsrgnivssgek...............ve....eidsstsfsfpvtadmaPn 69 
                 + d+   +v+s gn ++++                 +     e+ s + +s+++++dm+ +
  EFC37102.1 124 AVDE---MVNSIGNQLAQNALekkkeekfrivravpTGkqnsEVASVPFISITFSHDMIEE 181
                 3333...577766664232223444444444444430033447778888999999999876 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.7
                 TT-....BSS----.-.-S..............................................S....-EEEEEE--TT-----E CS
                 xxxxxxxxxxxxxx.xxxxxx...........................................xxxxxxxxxxxxxxxxxxxxxxx RF
     A2M_BRD  29 rdstlylvlsrgni.vssgek...........................................veeidsstsfsfpvtadmaPnar 71 
                 +++ +y+v+++ ++   +g+                                              ++ ++++ +++v+++ +P++ 
  EFC37102.1 807 KKEVTYEVFDNSRVkYLDGKVelsangsfvldlvipdnvnlgshsvtfsfdgqrfqqtvcwnhtF-KVEEFRTREYTVSSSIIPSSE 892
                 22233666655555533554466666666666666666666666665555555554444433321.444566666666666666554 PP

  == domain 3  score: 56.4 bits;  conditional E-value: 2.9e-18
                  ESSSS--TTSEEEEEEE-SS-.......EE-TT-....BSS----.-.-S...S....-EEEEEE--TT-----EE.EEEE..E-...........- CS
                  xxxxxxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxx...........x RF
     A2M_BRD    5 pdkeeykvGetakltvkstfa.......tverdstlylvlsrgni.vssgekveeidsstsfsfpvtadmaPnarv.vvyyirrd...........g 81  
                   +++ey++Ge ak+ + s+f+        + +++    ++++  + +ss      + +  ++++p+++++ Pn++v v ++ +++           +
  EFC37102.1 1170 FENDEYQPGEDAKVYIVSPFSgdctgvaWILCNR----LIKQETFdISSD-----V-GMYELTIPIKKEYRPNIQVkVQLVGKENyvdiddmtrvnP 1256
                  5789****************86666666666666....777777777555.....2.356****************888885666***********9 PP

                  CEEEEEEE----.-GGGB-EEEEE.EE...-SSSEEEEEE..E..E.....T-EEEEEEEEHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxx..xxxx.....xxxxxxxxxxxxxxxx RF
     A2M_BRD   82 evvadsvqlpvekdfenklsvsle.synetrPgeevtlkv..kasp.....gslvalaaVDksvlll 140 
                    +++s+ +++  + +++l+v+++ ++   +Pg+e++++v  k+++     +s+v+l++ D++vl++
  EFC37102.1 1257 TQASGSIDIQIS-KSSHELDVTVTpKDTILSPGKETSVTVlvKDKQgntvpNSEVCLIVCDQAVLDM 1322
                  99**********.99********9768899***998888744433366677*************986 PP

>> MG2  MG2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.7   0.0   8.7e-14   1.2e-10       2      88 ..     761     862 ..     760     873 .. 0.85
   2 ?    0.8   0.0      0.51     7e+02       6      55 ..    1033    1082 ..    1029    1121 .. 0.79
   3 ?    1.9   0.0      0.22     3e+02       9      42 ..    1283    1316 ..    1276    1329 .. 0.85

  Alignments for each domain:
  == domain 1  score: 41.7 bits;  conditional E-value: 8.7e-14
                 EEEEES-SEE-TT-EEEEEEEEES.........TTCSB---............EEEEEEEE-TTSSEEEEEEEEE-CTTEEEEEEE--TT--SEEEEEE CS
         MG2   2 afvytDRglYrPgetVslkallrd.........etlqglak............lplkltirdpdgkevkelplatdetggaesefalpeaaklGeysve 79 
                 a+++ DRglY+P+etV++k+++r+         e      +            ++++ ++ d ++ ++   +++ +++g++  ++ +p++  lG+ sv+
  EFC37102.1 761 AHIFNDRGLYKPNETVHIKGFIRNliydtnkdsE------NygtyaittqiskKEVTYEVFDNSRVKYLDGKVELSANGSFVLDLVIPDNVNLGSHSVT 853
                 79**********************9996655551......3444555666777********************************************** PP

                 EEECSTTT- CS
         MG2  80 lsadsaees 88 
                 +s d+++ +
  EFC37102.1 854 FSFDGQRFQ 862
                 *77776655 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.51
                  ES-SEE-TT-EEEEEEEEESTTCSB---EEEEEEEE-TTSSEEEEEEEEE CS
         MG2    6 tDRglYrPgetVslkallrdetlqglaklplkltirdpdgkevkelplat 55  
                  t R + +  e++   +++ d +++ +++ p+++++++ +      ++++t
  EFC37102.1 1033 TKRVVMKSDENIDCFFVVTDIKGKVVKDVPISVKLVQFGYDSKGYEKWET 1082
                  67889999*************************99987666555555544 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.22
                  SEE-TT-EEEEEEEEESTTCSB---EEEEEEEE- CS
         MG2    9 glYrPgetVslkallrdetlqglaklplkltird 42  
                  +++ Pg + s+++l++d++++++++ ++ l + d
  EFC37102.1 1283 TILSPGKETSVTVLVKDKQGNTVPNSEVCLIVCD 1316
                  6999*******************99998887766 PP

>> A2M  Alpha-2-macroglobulin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.9   0.0   4.8e-14   6.6e-11       4      89 ..    1474    1558 ..    1472    1561 .. 0.95
   2 ?   -3.5   0.0       7.2     1e+04      66      82 ..    2144    2160 ..    2143    2162 .. 0.88

  Alignments for each domain:
  == domain 1  score: 41.9 bits;  conditional E-value: 4.8e-14
                  EEEEEEC...CEEEEEEEEESSSCEEEEEEEEEETTTEEEEEEEEEEEE--SEEEEEE--SEEETTSEEEEEEEEEE-SSS-EEEE CS
         A2M    4 WedvlvtdasgkaslsftlPDsiTtWrvtavalsedkglgvaeplevrvfkpffvdlnlPysvrrgeqveikavvfNyldkeikvr 89  
                  +  + +td++g+ +l+f+l D +T+++vtav   ++  +g+ ++  +++  p+ v+++lP+++  g+   ++ ++ N++d++++ +
  EFC37102.1 1474 FIGFAQTDENGSITLDFKLTDALTKFKVTAVVNAKEDLIGIGSS-AITTNLPIAVRPSLPRFLNYGDLCDLTYILQNQTDSDLTLS 1558
                  66778999************************************.************************************99876 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 7.2
                  EETTSEEEEEEEEEE-S CS
         A2M   66 vrrgeqveikavvfNyl 82  
                  v+ ge v++++++ N +
  EFC37102.1 2144 VKSGELVRVNITICNPT 2160
                  799***********976 PP

>> Big_5  Bacterial Ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.1   0.00081       1.1       6     108 .]     150     258 ..     145     258 .. 0.73
   2 !   13.8   0.0   5.1e-05      0.07      24     106 ..     430     505 ..     408     507 .. 0.83
   3 ?    5.3   0.2     0.023        32      47      95 ..    1260    1305 ..    1232    1312 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00081
       Big_5   6 tvvstsPadg.atgvavnaeitvtFseav......dastvtaatvialsdsettavtgs.ydasgktvtitpsaeLaanttYtvtitag.ikDlagnal 95 
                 ++v  +P+ +   +va    i++tFs ++      + ++ +++ +i++s+ ++++ +g+   +  k ++++p+  ++ +t+++ ++ +   k + g +l
  EFC37102.1 150 RIVRAVPTGKqNSEVASVPFISITFSHDMieefdgETKSFEEIDFIEISPVTENVKEGKwKWIGTKSLVFQPRFRFDRSTEFSYKVIKEkTKSVHGHTL 248
                 56666666552336666668*********999988888888888888755555555555566666*****************99997766888888666 PP

       Big_5  96 aapytniewsFtT 108
                  ++ +    +F+T
  EFC37102.1 249 GDDLS---ATFKT 258
                 66444...77766 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 5.1e-05
       Big_5  24 eitvtFseavdastvtaatvialsdsettavtgsydasgktvtitpsaeLaanttYtvtitagikDlagna.laapytniewsF 106
                 ++t++F++++d ++v+++ +++  ++  ++ + +  a+g+t++i  ++ L a ++Y+v+i +g+ D   n+ + ++y+    +F
  EFC37102.1 430 SFTFRFNNPIDLEKVDSIEKFVQLEPVLNNYKVK--ADGNTIIIAGDT-L-AREKYSVKILKGVPDIY-NQiMESDYS---ATF 505
                 5799*****************7766667777766..999*99999776.7.99**************9.663555444...555 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.023
       Big_5   47 sdsettavtgsydasgktvtitpsae.LaanttYtvtitagikDlagnal 95  
                  s+s  ++++ s  +    vt+tp+++ L+++++ +vt+   +kD +gn++
  EFC37102.1 1260 SGSIDIQISKS--SHELDVTVTPKDTiLSPGKETSVTV--LVKDKQGNTV 1305
                  33334444444..777999*****777***********..8******964 PP

>> bMG3  Bacterial alpha-2-macroglobulin MG3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0     2e-05     0.028       1      40 [.     655     695 ..     655     742 .. 0.90
   2 ?   -1.4   0.1       1.8   2.5e+03      23      46 ..    1300    1323 ..    1287    1326 .. 0.79
   3 ?   -0.7   0.0         1   1.4e+03      43      75 ..    1475    1504 ..    1470    1515 .. 0.69
   4 ?    0.5   0.1      0.44   6.1e+02       9      37 ..    1587    1615 ..    1583    1622 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 2e-05
        bMG3   1 vtdlGlhaklg.rdkllvwvtsLdsgkPvagaeVrlldkkg 40 
                 v++l + + +   +kl v+vt  ++gkPv +aeV++ d k+
  EFC37102.1 655 VSNLCVDVVSIaGEKLGVFVTDFSTGKPVDNAEVTMFDTKN 695
                 6888887666547999*********************9887 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.8
        bMG3   23 dsgkPvagaeVrlldkkgevlaeg 46  
                  ++g++v++ eV l+ ++++vl  +
  EFC37102.1 1300 KQGNTVPNSEVCLIVCDQAVLDMA 1323
                  7899*************9999765 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 1
        bMG3   43 laegtTDaqGvarfaallargkegaapylvsAr 75  
                  ++ ++TD++G ++++ +l+    + + + v+A 
  EFC37102.1 1475 IGFAQTDENGSITLDFKLTD---ALTKFKVTAV 1504
                  67799*********999666...4444444443 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.44
        bMG3    9 klgrdkllvwvtsLdsgkPvagaeVrlld 37  
                   +gr+++ + v+ L+ gk++ ++ Vr++ 
  EFC37102.1 1587 AQGRKEVRIPVQVLKCGKALINIGVRVVR 1615
                  689***********************987 PP

>> ZirS_C  Zinc-regulated secreted antivirulence protein C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.85   1.2e+03      56      89 ..    1035    1068 ..    1013    1092 .. 0.81
   2 ?   12.8   0.5   4.6e-05     0.063      45      89 ..    1272    1315 ..    1230    1324 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.85
                  ---B-TT-EEEEEEE-BBTTS-B------B--EE CS
      ZirS_C   56 kavlspgesatittlvkdvdgnpvnevminkava 89  
                  + v+   e      +v d+ g+ v++v i +   
  EFC37102.1 1035 RVVMKSDENIDCFFVVTDIKGKVVKDVPISVKLV 1068
                  556777778888889************9988654 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 4.6e-05
                  B-GGG-EEE-----B-TT-EEEEEEE-BBTTS-B------B--EE CS
      ZirS_C   45 pspdltlisidkavlspgesatittlvkdvdgnpvnevminkava 89  
                     d+t+    +++lspg+ +++t lvkd +gn v +  +   v+
  EFC37102.1 1272 HELDVTVTPK-DTILSPGKETSVTVLVKDKQGNTVPNSEVCLIVC 1315
                  4456666554.589*******************998777665555 PP

>> DUF11  Domain of unknown function DUF11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       3.1   4.3e+03      29      52 ..     830     857 ..     828     889 .. 0.70
   2 ?   -1.4   0.1       2.1   2.9e+03       9      32 ..    1284    1307 ..    1274    1316 .. 0.77
   3 ?   12.5   0.2    0.0001      0.14       5      48 ..    2139    2180 ..    2134    2201 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 3.1
       DUF11  29 sangvvvtDtl.Paglayvsvsas...q 52 
                 sang  v D++ P ++++ s+s +    
  EFC37102.1 830 SANGSFVLDLViPDNVNLGSHSVTfsfD 857
                 567777888767*********9995552 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.1
       DUF11    9 evrpGdtvtytltvtNtgpasang 32  
                   + pG ++++t+ v+   +++ ++
  EFC37102.1 1284 ILSPGKETSVTVLVKDKQGNTVPN 1307
                  5689********999887777765 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 0.0001
       DUF11    5 vdksevrpGdtvtytltvtNtgpasangvvvtDtlPaglayvsv 48  
                   ++ +v++G+ v++++t  N+    +++v + D lPagl+ v  
  EFC37102.1 2139 TKTWKVKSGELVRVNITICNPT--RRYNVALVDKLPAGLEVVNP 2180
                  444489**************75..5678************9875 PP

>> PurA  PurA ssDNA and RNA-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       0.6   8.3e+02     118     138 ..    1575    1595 ..    1562    1684 .. 0.59
   2 ?   10.3   0.1   0.00024      0.33     119     212 ..    1847    1941 ..    1837    1948 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.6
        PurA  118 ksrgqrqqialPaqGlielrd 138 
                  ++r++   +++PaqG  e+r 
  EFC37102.1 1575 NQRKKGFSVVIPAQGRKEVRI 1595
                  456666788999999888873 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00024
        PurA  119 srgqrqqialPaqGlielrdalteliedygegdeddeeaelpeeksltvdnkrfyfd.vGsnkyGvflrisevksnyrnsitvPekalvrfreel 212 
                  s + ++q++  ++G+++  ++ltel ++   ++           k+ +v++k+ +f    ++k  v+  +  +ks +++ +t+   ++++f   +
  EFC37102.1 1847 SETDKEQVISLCEGILDHYNTLTELTQELNPESAAYLAMSIHRCKKEQVEEKKGFFAkFINEKISVYQWLEAIKSYFKENVTIDSGIYAHFITRY 1941
                  4556666666789********************999999**********9988666515666899*******************99999997665 PP

>> MG4  Macroglobulin domain MG4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1      0.26   3.6e+02      25      62 ..     678     724 ..     670     748 .. 0.69
   2 ?   -3.3   0.0       7.5     1e+04      31      67 ..     772     808 ..     765     814 .. 0.75
   3 ?    1.3   0.0      0.27   3.8e+02      21      44 ..    1049    1075 ..    1046    1103 .. 0.76
   4 ?    1.4   0.1      0.25   3.5e+02      31      86 ..    1231    1289 ..    1226    1293 .. 0.67
   5 ?    6.0   0.0    0.0092        13      17      65 ..    1292    1339 ..    1287    1367 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.26
         MG4  25 pdgspaknvpVkiealk.......seteekeslt..tdedGtakfsi 62 
                 + g+p+ n  V++  +k       + t + +s+t  t+e G+a+f++
  EFC37102.1 678 STGKPVDNAEVTMFDTKnyypdkeTRTMDVRSVTekTNERGMAYFTC 724
                 56999999999998855677777733444444444499*******98 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 7.5
         MG4  31 knvpVkiea.lkseteekeslttdedGtakfsintped 67 
                 +n++V i+  ++ +  ++ ++ +++ Gt +++  ++++
  EFC37102.1 772 PNETVHIKGfIR-NLIYDTNKDSENYGTYAITTQISKK 808
                 788899988544.7888888899999999999888775 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.27
         MG4   21 lvkdpdgspaknvpVkiealk....set 44  
                   v+d +g+ +k vp+++++++    s +
  EFC37102.1 1049 VVTDIKGKVVKDVPISVKLVQfgydS-K 1075
                  599***************96644421.2 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.25
         MG4   31 knvpVkiealk.......seteekeslttdedGtakfsintpedaksltitvktkdpslpeen 86  
                  +n++Vk+++++        ++++ +   t+++G + + i  ++++ +l++tv+ kd+ l++ +
  EFC37102.1 1231 PNIQVKVQLVGkenyvdiDDMTRVN--PTQASGSIDIQI--SKSSHELDVTVTPKDTILSPGK 1289
                  6888888886554443332222222..267777766655..8899999999999999998866 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.0092
         MG4   17 sikVlvkdpdgspaknvpVkiealkseteekeslttdedGtakfsintp 65  
                  s++Vlvkd++g+ ++n  V++ + + ++  + + ++ ed +  f+in +
  EFC37102.1 1292 SVTVLVKDKQGNTVPNSEVCLIVCD-QAVLDMANHSIEDPLSLFVINNS 1339
                  689******************9976.67777888889999999998876 PP

>> DUF4198  Domain of unknown function (DUF4198)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1   0.00075         1     159     199 ..     678     724 ..     662     728 .. 0.71
   2 ?   -3.1   0.0       6.2   8.6e+03     180     198 ..    1468    1489 ..    1462    1491 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00075
     DUF4198 159 ldGkPlagaeveveyggt...ryrdapdeikv.....ktdadGvvtftl 199
                   GkP+ +aev+++  ++      ++++++ v     kt++ G + ft+
  EFC37102.1 678 STGKPVDNAEVTMFDTKNyypD--KETRTMDVrsvteKTNERGMAYFTC 724
                 67**********8777764431..2333333366788**********96 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 6.2
     DUF4198  180 dapdeikv...ktdadGvvtft 198 
                   +pd++++   +td++G +t+ 
  EFC37102.1 1468 FKPDAAFIgfaQTDENGSITLD 1489
                  56677677777*******9986 PP

>> CarboxypepD_reg  Carboxypeptidase regulatory-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.5    0.0011       1.6       5      57 ..     673     738 ..     669     761 .. 0.69
   2 ?    1.8   0.0      0.22     3e+02      34      60 ..     829     860 ..     813     883 .. 0.84
   3 ?   -1.7   0.1       2.7   3.7e+03       2      21 ..    1293    1312 ..    1292    1314 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0011
  CarboxypepD_reg   5 rVtd.asgapiagatVtvtnadtg...........tvastttdadGafrlrglpp.gtysvtvsap 57 
                       Vtd ++g+p+ +a+Vt +++ +             + + +t++ G   +++++     s+ vs++
       EFC37102.1 673 FVTDfSTGKPVDNAEVTMFDTKNYypdketrtmdvRSVTEKTNERGMAYFTCIQGyHHVSIAVSKD 738
                      69**88*************76553555555555433555578999988888888766666666665 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.22
  CarboxypepD_reg  34 tdadGafrlrglpp.....gtysvtvsapGya 60 
                        a+G+f l+ + p     g++svt+s++G +
       EFC37102.1 829 LSANGSFVLDLVIPdnvnlGSHSVTFSFDGQR 860
                      5689999999887778889**********976 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 2.7
  CarboxypepD_reg    2 isGrVtdasgapiagatVtv 21  
                       ++  V+d++g+ +++ +V +
       EFC37102.1 1293 VTVLVKDKQGNTVPNSEVCL 1312
                       77789*********999865 PP

>> Big_1  Bacterial Ig-like domain (group 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.36   4.9e+02      13      51 ..     674     723 ..     669     725 .. 0.65
   2 ?   -3.1   0.1         6   8.2e+03      38      46 ..     970     978 ..     962     979 .. 0.82
   3 ?    1.0   0.0      0.31   4.3e+02      12      29 ..    1049    1066 ..    1046    1073 .. 0.89
   4 ?   10.1   0.1   0.00046      0.64       7      27 ..    1291    1311 ..    1288    1329 .. 0.84
   5 ?    0.8   0.0      0.35   4.8e+02      40      59 ..    1478    1497 ..    1469    1503 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.36
       Big_1  13 vkD.angnpvagatVt.fsvsg...gals......assgtTdanGkatvt 51 
                 v+D + g+pv +a+Vt f + +   ++ +      + + +T++ G+a +t
  EFC37102.1 674 VTDfSTGKPVDNAEVTmFDTKNyypDKETrtmdvrSVTEKTNERGMAYFT 723
                 55556788999999983444445543333456777888888888888776 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 6
       Big_1  38 ssgtTdanG 46 
                  +gtTd+nG
  EFC37102.1 970 INGTTDSNG 978
                 579*****9 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.31
       Big_1   12 tvkDangnpvagatVtfs 29  
                  +v+D +g++v++++++++
  EFC37102.1 1049 VVTDIKGKVVKDVPISVK 1066
                  79************9976 PP

  == domain 4  score: 10.1 bits;  conditional E-value: 0.00046
       Big_1    7 ntltatvkDangnpvagatVt 27  
                  + +t+ vkD++gn v++ +V 
  EFC37102.1 1291 TSVTVLVKDKQGNTVPNSEVC 1311
                  579**************9995 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.35
       Big_1   40 gtTdanGkatvtltstkagt 59  
                  ++Td+nG +t  ++ t a t
  EFC37102.1 1478 AQTDENGSITLDFKLTDALT 1497
                  79********9999888755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2273 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       781  (0.0435607); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 1.17u 0.33s 00:00:01.50 Elapsed: 00:00:00.52
# Mc/sec: 13077.08
//
Query:       EFC37103.1  [L=486]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-81  274.5   0.0    1.8e-81  274.0   0.0    1.2  1  Aldedh    Aldehyde dehydrogenase family


Domain annotation for each model (and alignments):
>> Aldedh  Aldehyde dehydrogenase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  274.0   0.0     1e-85   1.8e-81      51     462 .]      14     433 ..       2     433 .. 0.91

  Alignments for each domain:
  == domain 1  score: 274.0 bits;  conditional E-value: 1e-85
                 HHHHHHHHHHHHHHHHTHHHHHHHHHHHH---HHHHHHHHHHHHHHHHHHHHHHHH.HSEEEEEE.C...TTEEEEEEEEE-SEEEEEE-SSSCCHHHH CS
      Aldedh  51 eeRaeiLrkaadlleerkeelaeletletGkplaearaeveeaidvlryyaelaek.legevlps.s...egklalvrrePlGvvgaItPWNfPlllaa 144
                 e R+e L k+ +++ee+ke+  e+++++ G++    + ev  ++  +++  + +++ +++e +++ +     ++ ++r+ePlGvv++I+PWN+P++l+a
  EFC37103.1  14 EWREEQLDKFIAMFEENKEDWKEAQVKDLGQTEPLKTIEVGLSVGSAQFLKGDLKRlMKDEYVNIvNpanLPSEGFIRKEPLGVVLIIAPWNYPISLLA 112
                 66999***************************************************5555887776655566789************************ PP

                 HHHHHHHHTT-EEEEEE-TTSHHHHHHHHHHHHHTTS-TTSEEE--SSTCCHHHHHHH-TTESEEEEES-HHHHHHHHHHHHCTTSEEEEEE---EEEE CS
      Aldedh 145 wklapalaaGNtvvlKPaeetplsalllaelfeeaglPkgvlnvvtgsgsevgealvehpevdkvsftGstevgrkiakaaaknlkrvtlElGGknpli 243
                   l  alaaGN v+lKP+e +p ++  +a+l+ +  ++++ + v+ g +++v   l+++p  d++  tGs +vg+ +++aaa++l++vtlElGGk+pli
  EFC37103.1 113 IPLSGALAAGNLVILKPSEVSPNVSSTFAKLIPK-YFDEKYVRVIEG-DATVTTNLLKEP-YDHIFYTGSIRVGKIVMRAAAEHLTPVTLELGGKSPLI 208
                 **********************************.9***********.888999999865.8************************************* PP

                 E-TTSHHHHHHHHHHHHHHGGGGTSTTSEEEEEEEHHHHHHHHHHHHHHHHT--BS-TTSTT-SB---SSHHHHHHHHHHHHHHHHTTSEEEE-TTE.S CS
      Aldedh 244 vledaDldkaveaivkgafgnaGQvCiaasrllvqesiydefveklveaakklkvgdpldedtdvGPliseaqlekvekyveeakeegaklllGgeree 342
                 + +d D+  a+++i++g ++n+GQ+C+a+  +l+   i+d+f+ +l+ea++k+   dp + + d+  +++  +++++++++++ k+   k+++Gg    
  EFC37103.1 209 IDKDIDISVAANRIAWGKTFNNGQTCVAPDYVLLDGRIADKFIPALKEAITKMYGEDPSK-SPDYSRIVTGTHVKRLKAIIDQVKD---KVIYGG---- 299
                 *****************************************************9999965.99**********************9...89****.... PP

                 B-SSSTTEE--EEEES-TTTSHH.HHS---SSEEEEEEE............SSHHHHHHHHHSSSEESEEEEE-SBHHHHHHHHHHS-SSEEEESSS.S CS
      Aldedh 343 aglekgyfvePtvlanvtpdmri.aqeEiFGPVlsvikf............kdeeeaieiaNdteyGLaagvftkdleraervaerleaGnvyiNds.t 427
                 + +e+  +v+Pt++ n + +++i +qeE+FGP+l++i +            kd++  ++  N+    La ++++k+ + +er+++  + G v+iN+   
  EFC37103.1 300 NADESAKYVQPTLILNPDMENDIvMQEELFGPLLPIIIYgesksteypsvlKDLDAGLKFINQRSKPLALYIYSKNQQLVERIMKVTQSGAVGINECvL 398
                 4568889*********998877637***********987333322222222479999**************************************9955 PP

                 T--TTTSEB--CGGGEES-BSHHHHHHHTEEEEEE CS
      Aldedh 428 tgaaealpfgGvkqSglGreggkegleeytevktv 462
                 ++ +e+lpfgGv++Sg+G+ +g ++++ +t+ k+v
  EFC37103.1 399 QVGEEHLPFGGVGHSGMGAYHGDASFNTFTHQKSV 433
                 6666669*************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       508  (0.028334); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 3006.55
//
Query:       EFC37104.1  [L=793]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.5e-05   23.5   0.0    7.9e-05   22.8   0.0    1.4  1  Myb_DNA-binding  Myb-like DNA-binding domain
     0.0057   16.5   4.1     0.0057   16.5   4.1    3.4  4  ATP11            ATP11 protein


Domain annotation for each model (and alignments):
>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   8.8e-09   7.9e-05       3      46 .]     409     457 ..     407     457 .. 0.90

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 8.8e-09
                      SSBHHHHHHHHHHHHHHT...TCHHHHHHHHT..SS-HHHHHHHHHHHT CS
  Myb_DNA-binding   3 kWteeEdelLleavkkhG...nrWkkIaerlg..gRtekqcrsrwrnyl 46 
                       W+ e ++ ++++v+ +G    r+k+I + ++   +t  +++s++++y+
       EFC37104.1 409 MWSDELHQHFVQVVESLGvydARPKEIKKIMNvdFLTTTHIKSHLQKYR 457
                      6*****************96566********9855************96 PP

>> ATP11  ATP11 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   2.1      0.62   5.5e+03      54      84 ..      28      56 ..       8      84 .. 0.42
   2 ?   -0.8   0.3      0.11     1e+03      20      45 ..     363     392 ..     327     447 .. 0.63
   3 !   16.5   4.1   6.3e-07    0.0057       3      76 ..     453     523 ..     451     554 .. 0.56
   4 ?   -4.0   0.2       1.1     1e+04      51      60 ..     714     723 ..     686     735 .. 0.50

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 0.62
                XXXXXXXXXXXXXXXXXXXX---.......S CS
       ATP11 54 kekeakasssektekkesaakskkksksksp 84
                ++++++as +  +   +++a+s ++++++s+
  EFC37104.1 28 QQQQQPASFQ--SIYLQRTASSMQHQQQHSS 56
                1111111111..1111111111122222222 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.11
                 XXXXXXXXXXXXXXXXXXXXXXXXX....X CS
       ATP11  20 esieeLkeaykdkieekrkeaaaid....l 45 
                 +s e+L+++++d+ +ek+k +++ d    +
  EFC37104.1 363 SSNEKLEANAADEPSEKKKGRRRSDsgggN 392
                 344555555555555555544333322221 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 6.3e-07
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--- CS
       ATP11   3 lekYreKLeqkakeeglesieeLkeaykdkieekrkeaaaid..leesksesekekeakasssektekkesaaksk 76 
                 l+kYr+ L++ka++eg+  + +Lk+++ ++ + +++++ +++  +++    +e++++++++s+++ ++ ++a++++
  EFC37104.1 453 LQKYRTHLKKKAQQEGV-HLPSLKRSLGSSSSLTKSKR-KPKkkKNDD---KEENPTTTTTSTANIPSVTAATTTT 523
                 79***************.9*******966655555544.222112222...2222222222222233222222222 PP

  == domain 4  score: -4.0 bits;  conditional E-value: 1.1
                 XXXXXXXXXX CS
       ATP11  51 esekekeaka 60 
                 + ++++++++
  EFC37104.1 714 NVQQQQSQQQ 723
                 1111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (793 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2444  (0.136315); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.02u 0.38s 00:00:01.40 Elapsed: 00:00:00.58
# Mc/sec: 4105.36
//
Query:       EFC37105.1  [L=120]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.3e-13   49.4  10.0    6.2e-13   48.9  10.0    1.2  1  TM2              TM2 domain
  ------ inclusion threshold ------
       0.13   13.3   2.0       0.17   12.9   2.0    1.1  1  Rib_recp_KP_reg  Ribosome receptor lysine/proline rich region


Domain annotation for each model (and alignments):
>> TM2  TM2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.9  10.0   6.9e-17   6.2e-13       4      51 .]       3      51 ..       1      51 [. 0.95

  Alignments for each domain:
  == domain 1  score: 48.9 bits;  conditional E-value: 6.9e-17
         TM2  4 sklvaylLwf..fLGglGvHRFYlGktgsGvlqlltfvGglgiwwlidli 51
                  +vaylLw+    G +G+HRFYl  ++ G+++l+t+ G++gi++l+dli
  EFC37105.1  3 EQGVAYLLWLgcCIGLFGLHRFYLDSFILGIVWLVTG-GLFGIGQLVDLI 51
                579******9888************************.**********97 PP

>> Rib_recp_KP_reg  Ribosome receptor lysine/proline rich region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   2.0   1.9e-05      0.17      66      93 ..      65     107 ..      58     119 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.9e-05
  Rib_recp_KP_reg  66 eseaevvveaepaPvvaaapaavaePv...............k 93 
                      + + +vv+ ++++Pv+a++p+ v++Pv               +
       EFC37105.1  65 NNQKQVVITTTAQPVMAQQPVYVQQPVivqqpivgyvppqayV 107
                      5678899********************6544433333222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (120 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.31s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 780.86
//
Query:       EFC37106.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1178  (0.0657036); expected 358.6 (0.02)
Passed bias filter:                      628  (0.0350271); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.35u 0.23s 00:00:00.57 Elapsed: 00:00:00.35
# Mc/sec: 1389.83
//
Query:       EFC37107.1  [L=1170]
Description: chromodomain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.9e-10   39.9   0.1    6.1e-10   38.9   0.1    1.6  1  Chromo     Chromo (CHRromatin Organisation MOdifier) domain


Domain annotation for each model (and alignments):
>> Chromo  Chromo (CHRromatin Organisation MOdifier) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.9   0.1   3.4e-14   6.1e-10       3      52 ..      11      59 ..       9      61 .. 0.82

  Alignments for each domain:
  == domain 1  score: 38.9 bits;  conditional E-value: 3.4e-14
                EEEEEEEEEETTEECEEEEEEETTSTGGGTEEEEGGGCSSH.SHHHHHHHH CS
      Chromo  3 VerIidhrtdkdgleleYlVKWkglpysentWEpeenlekc.fqelideFk 52
                 e I+++r+ +++    YlVKW ++p +++tWE+ en+       +++eF+
  EFC37107.1 11 AEFILAKRYERGKP--LYLVKWANYPFDDCTWESYENVTLNgVMTIVEEFE 59
                699**********9..********************986544455566665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2664  (0.148586); expected 358.6 (0.02)
Passed bias filter:                      560  (0.0312343); expected 358.6 (0.02)
Passed Vit filter:                       196  (0.010932); expected 17.9 (0.001)
Passed Fwd filter:                        61  (0.00340231); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 2.15u 0.42s 00:00:02.57 Elapsed: 00:00:00.67
# Mc/sec: 5298.33
//
Query:       EFC37108.1  [L=859]
Description: cell division cycle 20 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.3e-28   96.2  15.1      4e-09   37.0   0.7    6.9  6  WD40         WD domain, G-beta repeat
    2.8e-19   69.2   9.1    1.1e-07   32.1   1.2    5.3  6  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
     0.0069   15.4   0.3       0.18   10.8   0.0    2.8  3  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
  ------ inclusion threshold ------
       0.01   15.2   0.0      0.092   12.0   0.1    2.1  2  WD40_like    WD40-like domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.1   1.1e-05     0.047      11      38 .]     547     574 ..     538     574 .. 0.91
   2 !   10.0   0.0    0.0003       1.3       5      34 ..     582     613 ..     578     614 .. 0.80
   3 !   37.0   0.7   8.9e-13     4e-09       2      38 .]     646     683 ..     645     683 .. 0.92
   4 !   12.7   0.1   4.2e-05      0.19       5      38 .]     694     731 ..     692     731 .. 0.76
   5 ?    2.0   0.1     0.099   4.5e+02      11      37 ..     745     773 ..     735     774 .. 0.76
   6 !   24.6   0.0   7.3e-09   3.3e-05       3      38 .]     780     816 ..     778     816 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.1e-05
                 SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  11 ssvtslafspdgawlasGsdDgtvriWd 38 
                 + vts+a+  dg+ +a G+ ++t+ iW+
  EFC37108.1 547 NTVTSVAWTIDGHHIAVGTNNCTIEIWN 574
                 45****************99*******8 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.0003
                 EEEESS.SSEEEEEEETTSSEEE.EEETTSEE CS
        WD40   5 rtltGH.ssvtslafspdgawla.sGsdDgtv 34 
                 r   GH   v sl+++p  + ++ sGs+Dg++
  EFC37108.1 582 RRMIGHqARVGSLSWNPRCQSILsSGSRDGKI 613
                 5567**666****99999999763789***98 PP

  == domain 3  score: 37.0 bits;  conditional E-value: 8.9e-13
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 q + +++GH + v++l++spdg+ lasG+ D+t++iWd
  EFC37108.1 646 QVVSVYSGHnQEVCGLKWSPDGSQLASGGNDNTLHIWD 683
                 56889****666*************************9 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 4.2e-05
                 EEEESS.SSEEEEEEETTSSEE.EEEE..TTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgawl.asGs..dDgtvriWd 38 
                  t+  H   v +la++p ++ l asG+   D+++++W+
  EFC37108.1 694 FTFNEHtAAVKALAWCPWQSNLlASGGgtADRKIHFWN 731
                 688999767****98877777626774447*******8 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.099
                 SSEEEEEEETTSSEEEEE...ETTSEEEEE CS
        WD40  11 ssvtslafspdgawlasG...sdDgtvriW 37 
                 s v+sl +s++ + l+s+   s  + + +W
  EFC37108.1 745 SQVCSLLWSKYDKELVSShgfS-QNQLIVW 773
                 3499**9*********984333.8888888 PP

  == domain 6  score: 24.6 bits;  conditional E-value: 7.3e-09
                 EEEEEESS.SSEEEEEEETTSSEEEEE.ETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasG.sdDgtvriWd 38 
                 ++ +ltGH s v +la spdg+ ++s+ + D+t+r+W+
  EFC37108.1 780 KVAELTGHtSRVLHLAQSPDGSSVVSAaG-DQTLRFWK 816
                 57889***777*************98836.*******6 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0     0.092   4.1e+02      41      80 ..     502     539 ..     487     542 .. 0.76
   2 !   32.1   1.2   2.4e-11   1.1e-07      27      90 ..     532     597 ..     505     599 .. 0.80
   3 ?    2.7   0.0     0.034   1.5e+02      38      70 ..     588     621 ..     586     632 .. 0.79
   4 !   20.7   0.0   8.5e-08   0.00038      34      71 ..     651     688 ..     642     695 .. 0.88
   5 !   12.9   0.2   2.3e-05       0.1      32      90 ..     696     753 ..     690     755 .. 0.85
   6 ?    3.8   0.0     0.016        70      17      68 ..     768     818 ..     760     834 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.092
  ANAPC4_WD40  41 vrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvks 80 
                   + L W+   +lLav+  d +v l da++g++ + +++++
   EFC37108.1 502 LNLLDWSS-QNLLAVSLFD-TVYLWDANNGNITKLMETND 539
                  56678875.5799999998.699********999888776 PP

  == domain 2  score: 32.1 bits;  conditional E-value: 2.4e-11
  ANAPC4_WD40  27 qrvwtl......eedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgWg 90 
                   +   l      ee+++d++v+s+aW  dg+ +av++++ ++++ ++e +++v+ +  ++  +v +l+W+
   EFC37108.1 532 TK---LmetndnEEEETDNTVTSVAWTIDGHHIAVGTNNCTIEIWNVERKTMVRRMIGHQA-RVGSLSWN 597
                  33...344477788999***************************************88888.6******7 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.034
  ANAPC4_WD40  38 dsevrsLaWkpd.gklLavaysdgevrlldaesg 70 
                  + +v sL+W+p   ++L  +  dg++  +d+  g
   EFC37108.1 588 QARVGSLSWNPRcQSILSSGSRDGKILNHDVRIG 621
                  77899*****9636799999*****988887655 PP

  == domain 4  score: 20.7 bits;  conditional E-value: 8.5e-08
  ANAPC4_WD40  34 edkedsevrsLaWkpdgklLavaysdgevrlldaesgk 71 
                   +++++ev +L+W+pdg+ La + +d+++++ da+s+ 
   EFC37108.1 651 YSGHNQEVCGLKWSPDGSQLASGGNDNTLHIWDASSAS 688
                  467899****************************9875 PP

  == domain 5  score: 12.9 bits;  conditional E-value: 2.3e-05
  ANAPC4_WD40  32 leedkedsevrsLaWkp.dgklLav..aysdgevrlldaesgkvvhslsvksekavtclgWg 90 
                  +  +++   v++LaW p + +lLa   +++d ++++ + ++g +++s+++ks+  v++l W+
   EFC37108.1 696 F--NEHTAAVKALAWCPwQSNLLASggGTADRKIHFWNTSNGALLNSVDTKSQ--VCSLLWS 753
                  4..678899******99456788883347899*******************99..9*****7 PP

  == domain 6  score: 3.8 bits;  conditional E-value: 0.016
  ANAPC4_WD40  17 gellvfRl.ngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldae 68 
                  ++l+v    + ++v +l  +++ s+v +La +pdg+  + a  d ++r+ ++ 
   EFC37108.1 768 NQLIVWKYpSLRKVAEL--TGHTSRVLHLAQSPDGSSVVSAAGDQTLRFWKIF 818
                  55555554455677777..8999***********************9987654 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.12   5.6e+02     187     217 ..     546     576 ..     509     593 .. 0.70
   2 ?    0.4   0.0     0.056   2.5e+02     175     214 ..     645     682 ..     626     688 .. 0.69
   3 !   10.8   0.0   3.9e-05      0.18     182     220 ..     782     821 ..     695     830 .. 0.60

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.12
    Ge1_WD40 187 hsliveaafspdGtalatasedGevkffqvy 217
                 + ++++ a++ dG  +a+ +++ ++  + v 
  EFC37108.1 546 DNTVTSVAWTIDGHHIAVGTNNCTIEIWNVE 576
                 3456666666666666666666666666654 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.056
    Ge1_WD40 175 eeieegllkieehsliveaafspdGtalatasedGevkff 214
                 +++ +++    ++ ++    +spdG  la   +d +++ +
  EFC37108.1 645 SQVVSVY--SGHNQEVCGLKWSPDGSQLASGGNDNTLHIW 682
                 4433332..22335788899***********999988877 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 3.9e-05
    Ge1_WD40 182 lkieehs.liveaafspdGtalatasedGevkffqvyled 220
                  +++ h+  + + a spdG ++  a+ d +++f++++ + 
  EFC37108.1 782 AELTGHTsRVLHLAQSPDGSSVVSAAGDQTLRFWKIFSSA 821
                 3344443269999***********************9765 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   2.1e-05     0.092      52     126 ..     518     593 ..     512     630 .. 0.77
   2 ?    0.4   0.0     0.071   3.2e+02       2      36 ..     657     691 ..     656     707 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.1e-05
   WD40_like  52 dddlilvvtlDGtillslleneeevenekieedistvkvi..ddklliGtnkGsiyvfskdlq.leevllgqsseIke 126
                  d ++l  ++ G+i ++l+e  +  e+e+ ++ ++ v  +  + ++++Gtn+ +i +++ + + ++  ++g+++ + +
  EFC37108.1 518 FDTVYLWDANNGNI-TKLME-TNDNEEEETDNTVTSVAWTidGHHIAVGTNNCTIEIWNVERKtMVRRMIGHQARVGS 593
                 577899999*****.44444.444688999999998875422679************998832133446777776655 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.071
   WD40_like   2 eiYsidiskkgslilyGgkddkctvlkleslesvs 36 
                 e+  +  s++gs ++ Gg+d+++ + +  s     
  EFC37108.1 657 EVCGLKWSPDGSQLASGGNDNTLHIWDASSASFSP 691
                 667788899****************9998876655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (859 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       676  (0.0377043); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.80u 0.33s 00:00:01.13 Elapsed: 00:00:00.55
# Mc/sec: 4704.48
//
Query:       EFC37109.1  [L=843]
Description: kinesin-14 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-80  270.2   3.9      2e-80  270.2   3.9    2.7  2  Kinesin       Kinesin motor domain
    2.5e-32  111.9   0.2    2.5e-32  111.9   0.2    3.2  3  Microtub_bd   Microtubule binding
     0.0034   17.7   0.1      0.047   14.0   0.0    2.7  2  AAA_22        AAA domain
  ------ inclusion threshold ------
      0.017   15.6   6.4       0.16   12.4   4.1    2.6  2  T3SSipB       Type III cell invasion protein SipB
      0.099   13.0   0.0       0.65   10.4   0.0    2.5  2  AAA_16        AAA ATPase domain
       0.22   10.9   3.8      0.082   12.3   0.5    1.9  2  PIN_5         PINc domain ribonuclease
       0.47   10.7   6.8        8.5    6.7   3.0    2.9  2  ABC_tran_CTD  ABC transporter C-terminal domain
        4.4    7.1   8.4          4    7.3   5.5    2.5  2  DivIC         Septum formation initiator


Domain annotation for each model (and alignments):
>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.9   4.6       4.5     1e+04     154     198 ..     302     346 ..     269     377 .. 0.57
   2 !  270.2   3.9     9e-84     2e-80       1     333 []     491     832 ..     491     832 .. 0.92

  Alignments for each domain:
  == domain 1  score: -4.9 bits;  conditional E-value: 4.5
                 BEEEECTTSCCEEETTS--EEESSHHHHHHHHHHHHHHHTSTTSS CS
     Kinesin 154 lkiredskkgevyvkgltevevksaeevlellekgeknrkvaetk 198
                  k  e +++ + +vk+lt+++ +++e+ +  +++ e+++k    +
  EFC37109.1 302 SKQSELKNYYQNFVKNLTKQHNQKLEDYQLRIKELENEKKQLRKE 346
                 233333333345666666666666666665555555555444443 PP

  == domain 2  score: 270.2 bits;  conditional E-value: 9e-84
                 EE-SSSHHHHTTTTEBCEEEEC...TCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHTTSEEEEEEEESTTSSHHHHHTBCT CS
     Kinesin   1 RvRplnekekeeeeeeevevee...ekkeeekkskkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvleGynatifaYGqtgsGKTyTmegke 96 
                 R+Rp+   e+e++ +++  + +   ++++++ +    ++  ++++f+ d+v++ e+tq+ +++++ +plv+s+++G+n++++ +G+tgsGKT+Tm+g+ 
  EFC37109.1 491 RIRPMWVLESEKNMAHNSYRVKsciSQEKTTDSVVAISRMGRNRSFELDQVYGMESTQDGIFSDI-RPLVSSAFDGFNTCLMVFGETGSGKTFTMNGS- 587
                 89999887777777776666655556666777777888999***********************5.*******************************8. PP

                 TTSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEEEEEETTEEEETTSTTTTSTSSEBEEEECTTSCCEEETTS--EEESSHHHHHHHHHHHHHHHTST CS
     Kinesin  97 eeeeGiipraleelFesikkekeekekefsvkvsylEiYneeiyDLLeskkskkkkklkiredskkgevyvkgltevevksaeevlellekgeknrkva 195
                   e+Gi+pr+++el+++++ ++    ++ ++++s+ E+Yn+e++DL++++k  +         +++     ++l+ v+v+s e++ ++++ +  +r+ +
  EFC37109.1 588 LVEPGIVPRSITELYRIMEVNQCY--YNANLRLSIAEVYNNELRDLINPEK--EY--------KSS-----NDLNYVKVESEEQLRQIIKDCIVKRTES 669
                 899***************998877..99********************992..22........222.....47999*********************** PP

                 TSSCTSHHCCSEEEEEEEEEEEETTTTTCEE............................EEEEEEEEEEEEECCCHHHHSSTCHHHHHHHHHHHHHHHH CS
     Kinesin 196 etklneeSSRSHavftitleqknlkeeteek............................vkisklnLvDLAGsErasktgaaegerlkEaaniNkSLla 266
                 +t +n++SSRSH+++++++e++ + +++e++                             + s l +vDLAGsE+++ +g   g++l+E++ +NkSL+a
  EFC37109.1 670 KTLMNSNSSRSHCIISVEIEKRVIPKKKENAsqlfeellgmktnnqqdffdellspqqvNTKSVLRFVDLAGSENVEMSGV-AGDQLTETSFVNKSLSA 767
                 **********************998887744579999*********************9999******************7.5888************* PP

                 HHHHHHHHHHTCCTSTSCGGGSHHHHHTGGGHSSSSEEEEEEEE-TBGGGHHHHHHHHHHHHHHCTT CS
     Kinesin 267 LgrvisaLaekkkskhipYRdSkLTrlLqdsLgGnsktlmivtvspssenleetlstlkfaerakei 333
                 L++vi aLa+k  +kh+p+R+S+LT++L+dsL+G+sk+l+ivtvsp+++  +et+++l+faer+k+i
  EFC37109.1 768 LEDVIVALASK--QKHVPFRNSRLTHVLKDSLSGDSKILIIVTVSPQERFGAETVHALSFAERVKSI 832
                 ***********..****************************************************97 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.8      0.67   1.5e+03     100     139 ..     297     337 ..     284     359 .. 0.71
   2 !  111.9   0.2   1.1e-35   2.5e-32       3     149 .]     467     632 ..     465     632 .. 0.89
   3 ?   -0.9   0.2      0.62   1.4e+03      43      70 ..     690     721 ..     651     733 .. 0.56

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.67
                  ........ST-HCHHHHHHHHHHCCTS.CCCCEEEEEEEEE CS
  Microtub_bd 100 megeeeeagmipraveeifetiselke.kgwkyeielqfve 139
                  me++ ++++ +++ ++++++ ++++++ k  +y+++++ +e
   EFC37109.1 297 MEKSMSKQSELKNYYQNFVKNLTKQHNqKLEDYQLRIKELE 337
                  66666666666777777666655543325667777666444 PP

  == domain 2  score: 111.9 bits;  conditional E-value: 1.1e-35
                  HHHHHHHHCHHHHHHHCTB-EEEEEEECCCS-T...........EEEETTT..................TTTEEEE-SEEEECTTHCCCCCCCCHHHH CS
  Microtub_bd   3 keetlRrkleNtiqelkGniRvfarvrpelesek..........akikfpe...............eekkkkkefsFdrvfeseseqeevfeeisqlv 75 
                  +e++ R+ l+N++ e +Gn Rv +r+rp+   e+          +     +               +   ++++f++d+v+  es+q+ +f++i+ lv
   EFC37109.1 467 HEQQVRKLLQNQLIEERGNLRVCCRIRPMWVLESeknmahnsyrV-----KscisqekttdsvvaiSRMGRNRSFELDQVYGMESTQDGIFSDIRPLV 559
                  7999************************97665444564444331.....13444556788999997789**************************** PP

                  HHHHTT--EEEEEEES................ST-HCHHHHHHHHHHCCTSCCCCEEEEEEEEEEESS-EEETT CS
  Microtub_bd  76 qsaldgynvcifaygqTGsGKtyTmegeeeeagmipraveeifetiselkekgwkyeielqfveiynekvqDlL 149
                   sa+dg n+c++  g+TGsGKt+Tm+g+  e+g +pr+++e++++++ + ++  + +++l++ e+yn++++Dl+
   EFC37109.1 560 SSAFDGFNTCLMVFGETGSGKTFTMNGSLVEPGIVPRSITELYRIMEVN-QCYYNANLRLSIAEVYNNELRDLI 632
                  ***********************************************99.789999****************96 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.62
                  T......TTTEEEE-SEEEECTT.HCCCCCCC CS
  Microtub_bd  43 e...eekkkkkefsFdrvfeses.eqeevfee 70 
                  +    +kk++ +  F+ ++  ++ +q+++f+e
   EFC37109.1 690 KrviPKKKENASQLFEELLGMKTnNQQDFFDE 721
                  24443344445555555555554455566665 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.48   1.1e+03      48      88 ..     302     353 ..     278     367 .. 0.73
   2 !   14.0   0.0   2.1e-05     0.047       6      70 ..     568     637 ..     566     673 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.48
      AAA_22  48 psstsskdllrellralglelka...........erlsseellealeqalra 88 
                 ++++++k+ +++++++l+ +++             ++++++l++ +++  ++
  EFC37109.1 302 SKQSELKNYYQNFVKNLTKQHNQkledyqlrikeLENEKKQLRKEVAESTND 353
                 4555888999999999999888877777777766666666666666665555 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 2.1e-05
      AAA_22   6 gilvvtGesGtGKTtllrrlleqldeeakaee.....erpevvfvtlpsstsskdllrellralglelka 70 
                 ++l+v+Ge+G+GKT++++  l +  +++   +     +++ + +++++   s ++++++ lr+l ++ k+
  EFC37109.1 568 TCLMVFGETGSGKTFTMNGSLVEPGIVPRSITelyriMEVNQCYYNANLRLSIAEVYNNELRDLINPEKE 637
                 699*************998777777776666666666666666666666667777766666666665555 PP

>> T3SSipB  Type III cell invasion protein SipB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   4.1   7.2e-05      0.16      18     111 ..     267     351 ..     261     390 .. 0.89
   2 ?    2.3   0.0     0.095   2.1e+02      17      53 ..     762     798 ..     758     803 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 7.2e-05
                 HCHHHHHHHHHHHHHHHHHTTTTT----STHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT---------CHHHHHHHHH CS
     T3SSipB  18 kSLsqLenrlaawkamskaqqeaasklSdelqtalseakgatddleaaiekadqaksaadaatkkvdeaqkrlkeLaPdePekakleaaeqQag 111
                 +S ++L++r+ +  a    ++++++ + + +++ +s+ +++++ +++ ++++       ++ ++k+++ q r+keL   e ek++l++++   +
  EFC37109.1 267 VSVNELQERISVLTAALLTANQKLEDFQNSMEKSMSKQSELKNYYQNFVKNL------TKQHNQKLEDYQLRIKEL---ENEKKQLRKEVAEST 351
                 799******************************************9888776......5788999***********...999999999987655 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.095
                 HHCHHHHHHHHHHHHHHHHHTTTTT----STHHHHHH CS
     T3SSipB  17 nkSLsqLenrlaawkamskaqqeaasklSdelqtals 53 
                 nkSLs+Le+ + a  +++k     +s+l  +l++ ls
  EFC37109.1 762 NKSLSALEDVIVALASKQKHVPFRNSRLTHVLKDSLS 798
                 9*******************************99887 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.4   3.2e+03      69     113 ..     310     345 ..     252     391 .. 0.54
   2 ?   10.4   0.0   0.00029      0.65      10      42 ..     553     585 ..     547     807 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.4
      AAA_16  69 ysa.laqalareellrqlldeaesaeleawrekleealaavpelag 113
                 y++ +++ l++ +  +         +le+++ +++e  ++ ++l+ 
  EFC37109.1 310 YYQnFVKNLTK-QHNQ---------KLEDYQLRIKELENEKKQLRK 345
                 22223333322.2222.........344444444443333333333 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00029
      AAA_16  10 eqLlsalervrsgrpelvllsGesGvGKsslvr 42 
                 + ++ +++++ +g   ++++ Ge G+GK+  ++
  EFC37109.1 553 SDIRPLVSSAFDGFNTCLMVFGETGSGKTFTMN 585
                 678889999999999**************9883 PP

>> PIN_5  PINc domain ribonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.2         1   2.2e+03     127     162 ..     322     356 ..     287     358 .. 0.62
   2 ?   12.3   0.5   3.7e-05     0.082      14     123 ..     370     479 ..     359     511 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1
       PIN_5 127 keeeeeevgelikklRekYrealRkGilDsaeDldv 162
                 ++++ e+ +  ik+l ++ ++ lRk + +s++D+ +
  EFC37109.1 322 HNQKLEDYQLRIKELENE-KKQLRKEVAESTNDVSI 356
                 333455666667777655.67789999999888876 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 3.7e-05
       PIN_5  14 vreklgeeeleeavkklldliaearlklgiscyippsvykElkeflkreeveeeviakldtwlvkkspdryevkipaeilyeyveevrerink..Glrv 110
                   + + +++ +++v++ ldl++ ++  l  ++   +    El++    + +++++++kl+t++++k+ ++ ++   ++++++ ++   +r  +   l v
  EFC37109.1 370 FSQVFVQTDACQVVNSNLDLLSFSKNAL--EVCRSTKSDLELMKTHVMNLIPSDMLQKLSTIIIRKTAEKLDIPTVTNFFQKKIQFQEDRFAQlnTLYV 466
                 5677889999*************99888..555556667899999999**************************99****9999999888875336778 PP

       PIN_5 111 aEeavreaaeese 123
                  E++vr+  +++ 
  EFC37109.1 467 HEQQVRKLLQNQL 479
                 8888888776665 PP

>> ABC_tran_CTD  ABC transporter C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.1      0.02        45      18      62 ..     270     312 ..     262     316 .. 0.78
   2 ?    6.7   3.0    0.0038       8.5       2      35 ..     318     351 ..     317     368 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.02
  ABC_tran_CTD  18 eaLEeeiaeleaeladpelysdpeklaelsaeleeleaeLeelye 62 
                   ++L+e+i+ l+a+l  ++  ++ e ++  +++    ++eL++ y+
    EFC37109.1 270 NELQERISVLTAALLTAN--QKLEDFQNSMEKSMSKQSELKNYYQ 312
                   678899999999998887..6667788888888888888888776 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0038
  ABC_tran_CTD   2 lsykeqreleeleaeIeaLEeeiaeleaeladpe 35 
                   l+ +  ++le    +I +LE+e+++l +e+a+ +
    EFC37109.1 318 LTKQHNQKLEDYQLRIKELENEKKQLRKEVAEST 351
                   67888999*********************99765 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.7   3.9e+03      23      30 ..     287     294 ..     267     321 .. 0.52
   2 ?    7.3   5.5    0.0018         4      20      59 ..     320     359 ..     313     361 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.7
                 HHHHHHHH CS
       DivIC  23 kqeiaalq 30 
                 +q++++ q
  EFC37109.1 287 NQKLEDFQ 294
                 22222222 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0018
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-XXXXXXXXX CS
       DivIC  20 kqlkqeiaalqaelaklkaeneeLeaevkdLksdedyiee 59 
                 kq +q++++ q  +++l +e+++L +ev++ ++d + ie 
  EFC37109.1 320 KQHNQKLEDYQLRIKELENEKKQLRKEVAESTNDVSIIES 359
                 678999****************************999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (843 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2978  (0.1661); expected 358.6 (0.02)
Passed bias filter:                      555  (0.0309554); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.91u 0.30s 00:00:01.21 Elapsed: 00:00:00.51
# Mc/sec: 4928.33
//
Query:       EFC37110.1  [L=357]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.5e-13   48.9  26.8      0.034   14.2   0.4    8.0  8  LRR_6       Leucine Rich repeat
    1.3e-09   37.7  27.1     0.0073   16.1   0.4    5.1  5  LRR_8       Leucine rich repeat
    3.3e-09   36.9  44.4     0.0049   17.2   2.5    6.9  7  LRR_4       Leucine Rich repeats (2 copies)
    7.9e-05   22.5   0.1    0.00018   21.4   0.1    1.6  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.013   16.2   4.5        2.3    9.1   0.2    3.8  3  DUF3744     ATP-binding cassette cobalt transporter
      0.021   14.4  11.5       0.33   10.4   2.2    2.6  2  LRR_9       Leucine-rich repeat
       0.11   12.2   0.4        1.2    8.8   0.2    2.3  2  DUF1251     Protein of unknown function (DUF1251)
       0.34   10.8   5.0        1.6    8.7   2.7    3.2  2  F-box       F-box domain
       0.56   11.0  28.5         26    5.9   0.1    8.9  9  LRR_1       Leucine Rich Repeat
        3.8    8.3   0.0        3.8    8.3   0.0    6.3 10  LRR_2       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       7.4   1.3e+04       4      10 ..     107     113 ..     107     114 .. 0.87
   2 ?    0.6   0.1      0.43   7.7e+02       3      11 ..     148     156 ..     146     166 .. 0.83
   3 !   12.1   0.4   8.7e-05      0.16       5      20 ..     174     189 ..     170     192 .. 0.83
   4 !   11.8   0.1   0.00011       0.2       3      24 .]     196     217 ..     194     217 .. 0.92
   5 !   13.9   0.1   2.4e-05     0.043       4      20 ..     221     237 ..     219     241 .. 0.87
   6 !   14.2   0.4   1.9e-05     0.034       4      21 ..     267     284 ..     264     286 .. 0.92
   7 ?    3.6   0.0     0.046        83       3      21 ..     290     308 ..     288     310 .. 0.86
   8 !    6.6   0.2     0.005         9       3      15 ..     314     326 ..     312     327 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 7.4
       LRR_6   4 hLteLdL 10 
                 +L+ L+L
  EFC37110.1 107 SLKRLNL 113
                 6999*98 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.43
       LRR_6   3 thLteLdLs 11 
                 + Lt+L+L+
  EFC37110.1 148 SRLTYLNLN 156
                 78*****96 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 8.7e-05
       LRR_6   5 LteLdLsgNdIgDeGa 20 
                 ++ L+Ls+N+Ig+e +
  EFC37110.1 174 IKNLNLSDNKIGNESC 189
                 789**********976 PP

  == domain 4  score: 11.8 bits;  conditional E-value: 0.00011
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt L L +++I+ +G+e L+
  EFC37110.1 196 KNLTILRLEDCNISEKGVEHLS 217
                 58*****************996 PP

  == domain 5  score: 13.9 bits;  conditional E-value: 2.4e-05
       LRR_6   4 hLteLdLsgNdIgDeGa 20 
                 +Lt L++s N I D+G 
  EFC37110.1 221 TLTILNVSKNRIEDDGF 237
                 8**************95 PP

  == domain 6  score: 14.2 bits;  conditional E-value: 1.9e-05
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                 +Lt+L+L  N I++eG++
  EFC37110.1 267 KLTSLNLGQNSIDNEGVK 284
                 8***************97 PP

  == domain 7  score: 3.6 bits;  conditional E-value: 0.046
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 t+L++L L  N ++ e ++
  EFC37110.1 290 TNLKTLTLENNVFQPEAVQ 308
                 89*********99999776 PP

  == domain 8  score: 6.6 bits;  conditional E-value: 0.005
       LRR_6   3 thLteLdLsgNdI 15 
                 ++++ LdL++N++
  EFC37110.1 314 SSMEVLDLRDNNL 326
                 799********98 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.82   1.5e+03      46      54 ..     106     114 ..      98     134 .. 0.60
   2 !   12.3   1.3   6.1e-05      0.11      21      61 .]     144     184 ..     141     184 .. 0.89
   3 !   16.1   0.4   4.1e-06    0.0073       2      58 ..     197     253 ..     196     256 .. 0.92
   4 !   14.2   3.1   1.5e-05     0.028      23      59 ..     264     300 ..     259     302 .. 0.71
   5 !   14.5   3.4   1.2e-05     0.022       1      44 [.     290     333 ..     290     345 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.82
                 TT--S-.EE CS
       LRR_8  46 sgLpsLrsL 54 
                 ++L++L  +
  EFC37110.1 106 DSLKRLNLI 114
                 333333333 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 6.1e-05
                 STT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  21 FkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                   +ls+L++L+L+  + t+ s + ++ ++ ++ L+Ls+N++
  EFC37110.1 144 IGNLSRLTYLNLNASSVTSESCQYIQKCELIKNLNLSDNKI 184
                 57899999999999999999999999999999999999987 PP

  == domain 3  score: 16.1 bits;  conditional E-value: 4.1e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 nLt+L L + ++++ + e  ++ + L++L+ s N+++      +  L++L+sL   +
  EFC37110.1 197 NLTILRLEDCNISEKGVEHLSQIETLTILNVSKNRIEDDGFVNICKLKNLTSLKAAS 253
                 9************************************99999999999999997665 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 1.5e-05
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +l +L++L+L++N+++    + +  L++L+ L+L++N
  EFC37110.1 264 NLIKLTSLNLGQNSIDNEGVKIIGELTNLKTLTLENN 300
                 6777777777777777777777777777777777777 PP

  == domain 5  score: 14.5 bits;  conditional E-value: 1.2e-05
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGG CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspga 44 
                 +nL++L L nN ++    +  ++ls+++vLdL++N+l++ + ++
  EFC37110.1 290 TNLKTLTLENNVFQPEAVQYLTKLSSMEVLDLRDNNLSFDNVKC 333
                 59***********************************9877555 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   3.0     0.065   1.2e+02      15      32 ..     139     157 ..      96     164 .. 0.76
   2 !   14.0   5.1   2.9e-05     0.052       4      34 ..     175     207 ..     173     216 .. 0.82
   3 !   13.4   1.4   4.5e-05     0.081       3      33 ..     222     254 ..     220     267 .. 0.71
   4 !   17.2   2.5   2.8e-06    0.0049       1      40 [.     244     279 ..     244     284 .. 0.91
   5 !   16.8   4.8   3.7e-06    0.0067       2      33 ..     267     300 ..     266     315 .. 0.80
   6 !    8.6   5.9    0.0015       2.7       1      38 [.     290     327 ..     290     341 .. 0.82
   7 !    7.5   0.7    0.0032       5.8       3      25 ..     316     342 ..     314     350 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.065
                 E-S-.HHH-TT--EEE-.- CS
       LRR_4  15 dipl.leklpnLkeLdLsg 32 
                 +i++ +++l  L++L+L+ 
  EFC37110.1 139 EIGNsIGNLSRLTYLNLNA 157
                 4555345699999999954 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 2.9e-05
                 -EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   4 evLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L+Ls+N++   +   l kl+nL+ L L ++n
  EFC37110.1 175 KNLNLSDNKIGNESClyLTKLKNLTILRLEDCN 207
                 78*********666656559*********9984 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 4.5e-05
                 --EEE--SS---E-S-HH..H-TT--EEE-.-S CS
       LRR_4   3 LevLdLsnNqltdiplle..klpnLkeLdLsgN 33 
                 L++L+ s N++ d ++ +  kl+nL++L   ++
  EFC37110.1 222 LTILNVSKNRIEDDGFVNicKLKNLTSLKAASC 254
                 9***********966644768******985444 PP

  == domain 4  score: 17.2 bits;  conditional E-value: 2.8e-06
                 SS--EEE--SS---E-S-HHH-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdld 40 
                 +nL++L  +++ + +i ++ +l +L++L+L +N    ++d
  EFC37110.1 244 KNLTSLKAASCSVESIKNITNLIKLTSLNLGQN----SID 279
                 79****************************778....554 PP

  == domain 5  score: 16.8 bits;  conditional E-value: 3.7e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 +L++L+L++N +   +   ++ l+nLk+L+L +N
  EFC37110.1 267 KLTSLNLGQNSIDNEGVkiIGELTNLKTLTLENN 300
                 8************777785445*********555 PP

  == domain 6  score: 8.6 bits;  conditional E-value: 0.0015
                 SS--EEE--SS---.E-S-.HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqlt.dipl.leklpnLkeLdLsgNnlitd 38 
                 +nL++L L nN  + +    l kl ++++LdL +N ++ +
  EFC37110.1 290 TNLKTLTLENNVFQpEAVQyLTKLSSMEVLDLRDN-NL-S 327
                 79********9999877778999*********666.44.3 PP

  == domain 7  score: 7.5 bits;  conditional E-value: 0.0032
                 --EEE--SS---.E-S-.HH..H-TT- CS
       LRR_4   3 LevLdLsnNqlt.dipl.le..klpnL 25 
                  evLdL++N+l+ d    l+  +lp+L
  EFC37110.1 316 MEVLDLRDNNLSfDNVKcLNatNLPKL 342
                 689********9665557666667777 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.1   9.8e-08   0.00018       1      38 [.      15      55 ..      15      57 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 9.8e-08
  F-box-like  1 isrLPdEiLl.qIFs.yLppsdLlr.lalVCrrWrrvaldt 38
                i+ LP Ei+  +IFs yL+++ +++ ++lVC++++ +  ++
  EFC37110.1 15 ILKLPSEIIGdEIFSkYLNFEFIISvCSLVCKQFYKCSVNC 55
                5789***77637**999****888879********998766 PP

>> DUF3744  ATP-binding cassette cobalt transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.1     0.013        23      15      45 ..     198     231 ..     188     235 .. 0.75
   2 ?    9.1   0.2    0.0013       2.3      15      38 ..     246     269 ..     245     281 .. 0.89
   3 ?    0.0   0.0      0.83   1.5e+03      30      43 ..     288     301 ..     277     332 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.013
     DUF3744  15 itaLKkagidltsl..nqlsnleklalsq.dkek 45 
                 +t L+  +++++++  ++ls++e+l++ +  k++
  EFC37110.1 198 LTILRLEDCNISEKgvEHLSQIETLTILNvSKNR 231
                 46667777888877999********998855555 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0013
     DUF3744  15 itaLKkagidltslnqlsnlekla 38 
                 +t LK+a ++++s+++++nl kl+
  EFC37110.1 246 LTSLKAASCSVESIKNITNLIKLT 269
                 689*****************9986 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.83
     DUF3744  30 qlsnleklalsqdk 43 
                 +l+nl++l+l+++ 
  EFC37110.1 288 ELTNLKTLTLENNV 301
                 68999999998733 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   2.2   0.00019      0.33      46     126 ..     176     254 ..     171     263 .. 0.73
   2 ?    9.6   1.6   0.00032      0.58      54     126 ..     256     327 ..     251     351 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00019
       LRR_9  46 tidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                  ++lsdn+i + ++  +l +lk l +     ++i+e+  e l ++e+l + n + +++ d d ++++ kl++l+ lk++ +
  EFC37110.1 176 NLNLSDNKIGN-ESCLYLTKLKNLTILRLEDCNISEKGVEHLSQIETLTILNVSKNRIED-DGFVNICKLKNLTSLKAASC 254
                 579******87.67779999**99999999999999999999999998777666666666.66666655555555554433 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00032
       LRR_9  54 irkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 +  + ++  l +l +l l +n i + + ++   l nl++l l nn +q  a ++ l++l+++e+l l +n ++
  EFC37110.1 256 VESIKNITNLIKLTSLNLGQNSIDNEGVKIIGELTNLKTLTLENNVFQPEA-VQYLTKLSSMEVLDLRDNNLS 327
                 556788889999***************9999**************998755.699**********99998875 PP

>> DUF1251  Protein of unknown function (DUF1251)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.2   0.00069       1.2      15      72 ..      49     104 ..      35     127 .. 0.78
   2 ?    0.9   0.0       0.2   3.5e+02      45      66 ..     220     239 ..     214     265 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00069
     DUF1251  15 yrielskkkvkvevdsfdnkylQatfkskeksvcvvNakdkqkeivFDGFvkedDesk 72 
                 y+++  ++k++v++  f ++   a  ++k++++  vN   ++ +  F  Fvk+ De++
  EFC37110.1  49 YKCS-VNCKLNVKIPRFYDEESFAK-CCKSERLKCVNEFVSDCPYSFEEFVKYLDECQ 104
                 2223.34899****99976666555.7888999999*999****************98 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.2
     DUF1251  45 ksvcvvNakdkqkeivFDGFvk 66 
                 ++++++N   ++++i  DGFv+
  EFC37110.1 220 ETLTILN--VSKNRIEDDGFVN 239
                 6789999..5677899999997 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   2.7   0.00092       1.6      23      46 ..      38      61 ..      13      63 .. 0.81
   2 ?   -0.4   0.0      0.64   1.1e+03      32      44 ..      69      81 ..      68      84 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00092
                HHHHCTT-HHHHHHHTTHHHHHHH CS
       F-box 23 llalrrVSkgwrilidsdrlwcks 46
                +  +++V+k ++++  +++l+ k+
  EFC37110.1 38 ISVCSLVCKQFYKCSVNCKLNVKI 61
                778*************99999886 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.64
                HHHHHHTTHHHHH CS
       F-box 32 gwrilidsdrlwc 44
                ++ ++++s rl+c
  EFC37110.1 69 SFAKCCKSERLKC 81
                5778889888887 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0        10   1.8e+04       4      14 ..      31      45 ..      30      48 .. 0.56
   2 ?   -0.6   0.5       1.9   3.4e+03       2       7 ..     108     113 ..     107     147 .. 0.73
   3 ?    0.5   0.0      0.84   1.5e+03       1      16 [.     149     164 ..     149     171 .. 0.62
   4 ?    1.7   0.3      0.35   6.3e+02       3      13 ..     175     185 ..     174     195 .. 0.75
   5 ?    5.0   0.1     0.029        51       1      20 [.     197     216 ..     197     218 .. 0.84
   6 ?    3.4   0.1     0.096   1.7e+02       2      16 ..     222     236 ..     221     259 .. 0.76
   7 ?    5.9   0.1     0.014        26       1      15 [.     267     281 ..     267     289 .. 0.79
   8 ?    4.0   0.0     0.061   1.1e+02       1      12 [.     291     302 ..     291     313 .. 0.84
   9 ?    4.2   0.1      0.05        90       3      13 ..     317     332 ..     315     351 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 10
       LRR_1  4 hLd....Lsnnpllg 14
                +L+    +s ++l +
  EFC37110.1 31 YLNfefiISVCSLVC 45
                566333357777755 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.9
       LRR_1   2 LrhLdL 7  
                 L++L+L
  EFC37110.1 108 LKRLNL 113
                 888887 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.84
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L+L+  + ++ +
  EFC37110.1 149 RLTYLNLNASSVTSES 164
                 699****655554444 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.35
       LRR_1   3 rhLdLsnnpll 13 
                 + L+Ls+n ++
  EFC37110.1 175 KNLNLSDNKIG 185
                 679*****984 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.029
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL+ L L++++++ ++ +++
  EFC37110.1 197 NLTILRLEDCNISEKGVEHL 216
                 8**********987777766 PP

  == domain 6  score: 3.4 bits;  conditional E-value: 0.096
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L+ L++s n++++ +
  EFC37110.1 222 LTILNVSKNRIEDDG 236
                 999*******94433 PP

  == domain 7  score: 5.9 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L+L++n++++ 
  EFC37110.1 267 KLTSLNLGQNSIDNE 281
                 79*********9544 PP

  == domain 8  score: 4.0 bits;  conditional E-value: 0.061
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L L+nn +
  EFC37110.1 291 NLKTLTLENNVF 302
                 8*********76 PP

  == domain 9  score: 4.2 bits;  conditional E-value: 0.05
       LRR_1   3 rhLdLsnnpl.....l 13 
                 ++LdL++n+l      
  EFC37110.1 317 EVLDLRDNNLsfdnvK 332
                 79*******9544441 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       7.1   1.3e+04      18      25 ..      34      41 ..      30      42 .. 0.84
   2 ?   -1.2   0.1       2.2   3.9e+03      11      20 ..      63      72 ..      63      72 .. 0.87
   3 ?   -0.1   0.1      0.99   1.8e+03       9      21 ..      96     108 ..      95     108 .. 0.79
   4 ?   -1.4   0.0       2.5   4.5e+03       1       8 [.     107     114 ..     107     120 .. 0.82
   5 ?   -4.0   0.2        10   1.8e+04       1       7 [.     127     133 ..     127     133 .. 0.79
   6 ?    3.1   0.0     0.097   1.7e+02       3      18 ..     175     190 ..     173     195 .. 0.85
   7 ?   -2.2   0.0       4.6   8.2e+03       2      12 ..     198     208 ..     194     212 .. 0.60
   8 ?   -2.5   0.0       5.6     1e+04       4      20 ..     224     239 ..     222     240 .. 0.69
   9 ?    8.3   0.0    0.0021       3.8       1      13 [.     291     305 ..     291     313 .. 0.77
  10 ?   -3.3   0.0       9.9   1.8e+04       5      11 ..     326     332 ..     318     341 .. 0.64

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 7.1
       LRR_2 18 lekLLSgC 25
                +e ++S C
  EFC37110.1 34 FEFIISVC 41
                88899999 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 2.2
       LRR_2 11 rfsdedslek 20
                rf de+s+ k
  EFC37110.1 63 RFYDEESFAK 72
                799****976 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.99
       LRR_2   9 sVrfsdedslekL 21 
                  V++ de+ + +L
  EFC37110.1  96 FVKYLDECQFDSL 108
                 6999999988766 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 2.5
       LRR_2   1 sLKtLhLd 8  
                 sLK L+L 
  EFC37110.1 107 SLKRLNLI 114
                 8****995 PP

  == domain 5  score: -4.0 bits;  conditional E-value: 10
       LRR_2   1 sLKtLhL 7  
                 sL +L+L
  EFC37110.1 127 SLESLSL 133
                 7888987 PP

  == domain 6  score: 3.1 bits;  conditional E-value: 0.097
       LRR_2   3 KtLhLdsVrfsdedsl 18 
                 K L+L+++++ +e +l
  EFC37110.1 175 KNLNLSDNKIGNESCL 190
                 99********888665 PP

  == domain 7  score: -2.2 bits;  conditional E-value: 4.6
       LRR_2   2 LKtLhLdsVrf 12 
                 L +L L+++ +
  EFC37110.1 198 LTILRLEDCNI 208
                 44566666665 PP

  == domain 8  score: -2.5 bits;  conditional E-value: 5.6
       LRR_2   4 tLhLdsVrfsdedslek 20 
                 +L+ + +r+ d+ ++++
  EFC37110.1 224 ILNVSKNRIEDD-GFVN 239
                 577788999777.5654 PP

  == domain 9  score: 8.3 bits;  conditional E-value: 0.0021
       LRR_2   1 sLKtLhLdsVrf..s 13 
                 +LKtL L++++f   
  EFC37110.1 291 NLKTLTLENNVFqpE 305
                 6**********9543 PP

  == domain 10  score: -3.3 bits;  conditional E-value: 9.9
       LRR_2   5 LhLdsVr 11 
                 L+ d+V+
  EFC37110.1 326 LSFDNVK 332
                 4555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (357 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       550  (0.0306766); expected 358.6 (0.02)
Passed bias filter:                      253  (0.0141112); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 2163.22
//
Query:       EFC37111.1  [L=410]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1098  (0.0612416); expected 358.6 (0.02)
Passed bias filter:                      435  (0.0242624); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2516.04
//
Query:       EFC37112.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       568  (0.0316805); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1445.31
//
Query:       EFC37113.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.26   11.9   0.0       0.42   11.2   0.0    1.2  1  Stimulus_sens_1  Stimulus-sensing domain


Domain annotation for each model (and alignments):
>> Stimulus_sens_1  Stimulus-sensing domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   2.3e-05      0.42      19      43 ..     170     193 ..     164     202 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.3e-05
  Stimulus_sens_1  19 tRarlYdpdGkLvaDSrtlyssrge 43 
                      +  ++Y++dG +v+DS+ l++  ++
       EFC37113.1 170 NQRIIYSSDGIIVLDSKKLEKV-QQ 193
                      5668***************943.33 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1386.64
//
Query:       EFC37114.1  [L=1567]
Description: ATS1 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-15   57.7  24.6    0.00014   22.4   0.0    9.3  9  RCC1        Regulator of chromosome condensation (RCC1) repea
    7.1e-13   48.0  29.0      0.012   15.4   0.3    9.1 10  RCC1_2      Regulator of chromosome condensation (RCC1) repea
    4.1e-06   26.6   0.0    1.2e-05   25.1   0.0    1.8  1  F-box-like  F-box-like
     0.0059   16.9   9.2      0.014   15.7   9.2    1.6  1  EGF_2       EGF-like domain


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.0   0.00013      0.59       4      30 ..     705     731 ..     704     770 .. 0.80
   2 ?    4.0   0.1     0.018        80       1      32 [.     900     932 ..     900     940 .. 0.64
   3 !   22.4   0.0   3.2e-08   0.00014       2      43 ..     952     995 ..     951     998 .. 0.89
   4 ?   -3.4   0.2       3.5   1.6e+04       4      13 ..    1008    1017 ..    1007    1017 .. 0.84
   5 !    7.8   0.0    0.0011         5       1      29 [.    1120    1148 ..    1120    1167 .. 0.75
   6 ?    0.2   0.0      0.27   1.2e+03      12      40 ..    1188    1224 ..    1185    1234 .. 0.58
   7 !   18.8   0.1   4.2e-07    0.0019       1      45 [.    1237    1283 ..    1237    1287 .. 0.87
   8 ?    2.0   0.3     0.074   3.3e+02      35      44 ..    1372    1385 ..    1340    1389 .. 0.51
   9 ?    0.2   0.8      0.26   1.2e+03       1      14 [.    1435    1448 ..    1435    1449 .. 0.95

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00013
                 EEEEE--GGGTTSSSS---EEEEEE-G CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkve 30 
                 ++ WG+n yG LG +   s ++P++v+
  EFC37114.1 705 ILVWGSNMYGNLGYPLLASASTPVEVT 731
                 689**************99999*9984 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.018
                 TTEEEEEE--GGGTTSSSS-.--EEEEEE-GGG CS
        RCC1   1 dGrVysWGrndyGqLGlgtt.esvlvPtkvegl 32 
                 +G+V+sWG  + G   + +  e+ ++Pt++++l
  EFC37114.1 900 SGHVFSWGGWNSGIRSHTSGtENMNTPTLIPLL 932
                 59******5555443332223555777777766 PP

  == domain 3  score: 22.4 bits;  conditional E-value: 3.2e-08
                 TEEEEEE--GGGTTSSSS---E.EEEEE-GGGTTS.-EEEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesv.lvPtkveglsgn.rvvkvacG 43 
                 G+V+ WG n +G LGlg++ +  + P+++++  ++ ++vkv+ G
  EFC37114.1 952 GHVLVWGDNAFGALGLGNNANTySDPQLLPLDYSTeKAVKVCLG 995
                 99*****************555277****9999999***99987 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 3.5
                  EEEEE--GGG CS
        RCC1    4 VysWGrndyG 13  
                  Vy +G n+ G
  EFC37114.1 1008 VYVFGTNQGG 1017
                  9****99865 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.0011
                  TTEEEEEE--GGGTTSSSS---EEEEEE- CS
        RCC1    1 dGrVysWGrndyGqLGlgttesvlvPtkv 29  
                  +G+++++G n + q+G g+ +    P+ +
  EFC37114.1 1120 SGKIFAFGDNFQAQMGYGDVKLLQQPSPL 1148
                  59****************99444445444 PP

  == domain 6  score: 0.2 bits;  conditional E-value: 0.27
                  GGTTSS......SS---EEEEEE-..GGGTTS-EEEE CS
        RCC1   12 yGqLGl......gttesvlvPtkv..eglsgnrvvkv 40  
                  +G + +      ++ +s ++P++v  ++++++++v++
  EFC37114.1 1188 WGACENslslnsQSIKSTTLPQRVnsTLFNNTEIVDI 1224
                  44444432222144577799****5444444488887 PP

  == domain 7  score: 18.8 bits;  conditional E-value: 4.2e-07
                  TTEEEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS.-EEEEEEETT CS
        RCC1    1 dGrVysWGrndyGqLGlgtt.esvlvPtkveglsgn.rvvkvacGdd 45  
                  +G+Vy+WG++d + LG  +   s ++P  + + + n +++k+a+G  
  EFC37114.1 1237 SGKVYGWGSGDGYPLGVSNLySSLSTPIDLFSENTNwNATKIASGTK 1283
                  59******************777799*999666666*********86 PP

  == domain 8  score: 2.0 bits;  conditional E-value: 0.074
                  S....-EEEEEEET CS
        RCC1   35 n....rvvkvacGd 44  
                       +++k++cG+
  EFC37114.1 1372 SigskKIIKIVCGS 1385
                  12345999999997 PP

  == domain 9  score: 0.2 bits;  conditional E-value: 0.26
                  TTEEEEEE--GGGT CS
        RCC1    1 dGrVysWGrndyGq 14  
                  +G++y+ G n+y+q
  EFC37114.1 1435 NGNIYGTGYNQYHQ 1448
                  69**********99 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.27   1.2e+03      19      26 ..     704     711 ..     701     715 .. 0.81
   2 ?   -3.2   0.0       1.8   7.9e+03      19      28 ..     785     794 ..     783     794 .. 0.78
   3 !   15.0   1.9   3.5e-06     0.016       5      27 ..     888     911 ..     885     912 .. 0.90
   4 !   10.5   0.1   8.9e-05       0.4      13      29 ..     947     963 ..     945     964 .. 0.91
   5 !    4.3   0.0    0.0084        37      12      27 ..    1000    1015 ..     990    1018 .. 0.85
   6 ?   -3.6   0.0       2.5   1.1e+04      20      25 ..    1075    1080 ..    1073    1081 .. 0.86
   7 ?    2.3   0.0     0.034   1.5e+02      16      26 ..    1119    1129 ..    1111    1133 .. 0.86
   8 !   15.4   0.3   2.7e-06     0.012       8      26 ..    1228    1246 ..    1221    1249 .. 0.79
   9 ?    2.2   0.0     0.036   1.6e+02      13      27 ..    1336    1350 ..    1333    1351 .. 0.88
  10 !   10.5   0.3   9.4e-05      0.42       1      30 []    1415    1448 ..    1415    1448 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.27
      RCC1_2  19 eVlcWGsN 26 
                 e+l WGsN
  EFC37114.1 704 EILVWGSN 711
                 5899***9 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.8
      RCC1_2  19 eVlcWGsNsd 28 
                 ++l+ G+Ns+
  EFC37114.1 785 TILAAGDNSN 794
                 6899999985 PP

  == domain 3  score: 15.0 bits;  conditional E-value: 3.5e-06
      RCC1_2   5 saGdyHscaLtedGeVlcWG.sNs 27 
                 ++G+  +++L+++G+V++WG +Ns
  EFC37114.1 888 AFGSETYFVLMNSGHVFSWGgWNS 911
                 689999**************6676 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 8.9e-05
      RCC1_2  13 aLtedGeVlcWGsNsdG 29 
                 a+ ++G+Vl WG+N +G
  EFC37114.1 947 AINTTGHVLVWGDNAFG 963
                 78899*********998 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.0084
      RCC1_2   12 caLtedGeVlcWGsNs 27  
                   +Lte+ +V+ +G N 
  EFC37114.1 1000 TVLTESKHVYVFGTNQ 1015
                  59***********997 PP

  == domain 6  score: -3.6 bits;  conditional E-value: 2.5
      RCC1_2   20 VlcWGs 25  
                  +l+WG+
  EFC37114.1 1075 LLSWGR 1080
                  89***6 PP

  == domain 7  score: 2.3 bits;  conditional E-value: 0.034
      RCC1_2   16 edGeVlcWGsN 26  
                  ++G+++++G+N
  EFC37114.1 1119 NSGKIFAFGDN 1129
                  79********9 PP

  == domain 8  score: 15.4 bits;  conditional E-value: 2.7e-06
      RCC1_2    8 dyHscaLtedGeVlcWGsN 26  
                  +   ++Lt++G+V++WGs 
  EFC37114.1 1228 STNGLVLTSSGKVYGWGSG 1246
                  55689************94 PP

  == domain 9  score: 2.2 bits;  conditional E-value: 0.036
      RCC1_2   13 aLtedGeVlcWGsNs 27  
                  +Lt +G+V++ G+N 
  EFC37114.1 1336 ILTKSGKVFGLGNNA 1350
                  69***********95 PP

  == domain 10  score: 10.5 bits;  conditional E-value: 9.4e-05
      RCC1_2    1 VksvsaGdyH....scaLtedGeVlcWGsNsdGQ 30  
                  V+++s Gdy      + +t++G+++++G N + Q
  EFC37114.1 1415 VVDISNGDYNnfytNLYITNNGNIYGTGYNQYHQ 1448
                  6677766666677799**************9987 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.0   2.7e-09   1.2e-05       5      36 ..     225     257 ..     222     265 .. 0.88

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 2.7e-09
  F-box-like   5 PdEiLlqIFsyLppsdLlr.lalVCrrWrrval 36 
                 P E+LlqIFs+L+ + L   + lVC++W++ ++
  EFC37114.1 225 PYELLLQIFSFLDWKMLHKsINLVCKDWNDSIS 257
                 9************99999978********9984 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   9.2   3.2e-06     0.014       5      32 .]    1501    1527 ..    1496    1527 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3.2e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+ +G C+ q  +C+C+s+y G  C
  EFC37114.1 1501 SDACSSNGFCIGQD-NCRCFSKYNGTRC 1527
                  689********888.7***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1567 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1319  (0.073568); expected 358.6 (0.02)
Passed bias filter:                      627  (0.0349713); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.11u 0.32s 00:00:01.43 Elapsed: 00:00:00.50
# Mc/sec: 9361.26
//
Query:       EFC37115.1  [L=215]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1374.18
//
Query:       EFC37116.1  [L=534]
Description: POZ/BTB domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-06   26.8   0.1    0.00022   20.8   0.0    2.5  2  Ras            Ras family
    0.00014   22.1   0.5    0.00037   20.7   0.1    2.0  2  BTB            BTB/POZ domain
  ------ inclusion threshold ------
       0.13   12.0   0.3       0.25   11.1   0.3    1.4  1  Adenine_glyco  Methyladenine glycosylase
       0.21   11.7   1.0        0.4   10.7   0.1    1.8  2  CEL_III_C      CEL-III C-terminal


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.012        52       9      40 ..     407     436 ..     399     451 .. 0.74
   2 !   20.8   0.0     5e-08   0.00022      71     146 ..     452     529 ..     442     532 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.012
                 TSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEE CS
         Ras   9 avGKtslllrfvkdkFkeeyesTigvdfytke 40 
                   G  sll++f+ ++F++++++ +  + y ++
  EFC37116.1 407 DSGANSLLHQFAYNTFHSNSHEKV--NIYYQN 436
                 46999************9998877..444444 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 5e-08
                 TESEEEEEEETTB..HHHHHTHHHHHHHHHHHSTTTSEEEEEEETTTGGG.G-SS-HHHHHHHHHHHTSEEEEEBTTTT CS
         Ras  71 daegillvydits..resfenvkkwveeikrvaeenvpivLvGnKvDlee.kravsteegeelakelglkfletSAktn 146
                 +++ +++++++t+  ++ f ++++++++  +  +  ++++L+++K+Dl +    +s+ee   +ak+++l+  etSA t 
  EFC37116.1 452 KSTSLVICFSVTDtkENVFPQIQSIIKNGGTGIQ-ATQFLLLATKCDLPRvCWRISREEMFLFAKQNKLMLAETSALTG 529
                 4567899****86225689999999999999888.59***********985678**********************986 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.5   6.8e+03      24      44 ..      65      85 ..      50     121 .. 0.63
   2 !   20.7   0.1   8.2e-08   0.00037      31     110 ..     247     322 ..     236     323 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.5
                EE-HHHHHHH-HHHHHHHTST CS
         BTB 24 kahkavLaarSpyFkalftsk 44
                + h  +++  S+  +++++++
  EFC37116.1 65 HIHTEIVSTFSKLISKQVKEG 85
                445555555555555555555 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 8.2e-08
                 HHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  31 aarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlkkaceeflkqs 110
                   rSp+F++l++s+ + e s+ +i   dv+++ +e +L fi tg++++  ++ + el+   d+  ++ l + c + +k+s
  EFC37116.1 247 RYRSPFFNTLLSSG-MIECSQ-RIVPMDVSSSLLETILLFIMTGNIQN--DSIAIELMLYCDMVGFDILSNYCAHVIKES 322
                 579***********.666665.5889*********************9..477777777778888888888888777765 PP

>> Adenine_glyco  Methyladenine glycosylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.3   5.6e-05      0.25      78     146 ..      15      84 ..       2      91 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.6e-05
  Adenine_glyco  78 egiirnrlKieavisnAravlalqeefgsfseylwsfv...dgkpiveelksaeevpattelsealskdLkk 146
                    + iirn+++i+   +n +++ + ++e ++fs+ + +f    dg++i+ + +   +++  ++ s+ +sk+ k+
     EFC37116.1  15 PIIIRNEKRISNLNRNTTIIEEEKAELQNFSSECFTFHfivDGTKISITKH--IHTEIVSTFSKLISKQVKE 84 
                    679***************************997777665566666665544..3455667789999999885 PP

>> CEL_III_C  CEL-III C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1     9e-05       0.4      43     100 ..      46     106 ..      20     128 .. 0.67
   2 ?   -2.0   0.1      0.75   3.4e+03      97     117 ..     414     435 ..     391     475 .. 0.60

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 9e-05
   CEL_III_C  43 sieegfeflgksekasvsaeasvavadsvtkslsksvtttita..tca.kkdkekvalyQw 100
                 s    f+f   ++k+s++ +  +++ ++++k +sk+v+   +   t + +k++ k  +y +
  EFC37116.1  46 SECFTFHFIVDGTKISITKHIHTEIVSTFSKLISKQVKEGEELefTFEiAKKQFKGLVYLY 106
                 223356677***************************9986554003334444444444444 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.75
   CEL_III_C  97 lyQwslkgqe.egeeevsvdde 117
                 l+Q+ +++ + + +e+v+++ +
  EFC37116.1 414 LHQFAYNTFHsNSHEKVNIYYQ 435
                 5555554433233333333322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (534 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       765  (0.0426683); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 3260.33
//
Query:       EFC37117.1  [L=855]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0032   17.4  78.4        0.2   11.6  36.3    2.3  2  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0  35.6   1.8e-05      0.32      60     111 ..       2      53 ..       1      56 [. 0.56
   2 !   11.6  36.3   1.1e-05       0.2      60     111 ..      56     107 ..      52     112 .. 0.49

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.8e-05
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  +p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC37117.1   2 KPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 53 
                  4555555555555555555555666666666666666666666666666665 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 1.1e-05
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  +p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC37117.1  56 QPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 107
                  3444444444444444444444555555555555555555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (855 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       777  (0.0433376); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.92u 0.30s 00:00:01.22 Elapsed: 00:00:00.50
# Mc/sec: 5166.74
//
Query:       EFC37118.1  [L=925]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-35  122.6   7.6    1.2e-21   77.0   0.0    4.0  3  Peptidase_C2   Calpain family cysteine protease


Domain annotation for each model (and alignments):
>> Peptidase_C2  Calpain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.8   0.1    0.0013        24      18      37 ..     269     288 ..     254     311 .. 0.60
   2 !   77.0   0.0   6.9e-26   1.2e-21      36     232 ..     351     607 ..     321     622 .. 0.68
   3 !   40.0   2.5   1.2e-14   2.2e-10     229     294 ..     658     726 ..     645     728 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.0013
  Peptidase_C2  18 skkkkkkveWkRpkeivenp 37 
                   +++ +k ++W+Rp+ei+e +
    EFC37118.1 269 KEQLSKLYKWLRPHEIIEMK 288
                   34566789********9842 PP

  == domain 2  score: 77.0 bits;  conditional E-value: 6.9e-26
  Peptidase_C2  36 npkfi.vdgasrtdikqGel.gdCwllaaiasltlkekllkrvvpkeq..........sfeekyaGifhfrfwrfgewvdvvvDDrlPt.vngklvf 119
                    p++i  d++++ +i q ++  dC ++a++++ +l e+  k+ + ++            f  +  G ++++++ +g   +v++DD+lP+ +ng+l+ 
    EFC37118.1 351 YPTLIyQDEINEENIVQSHVvTDCSFVASLCVAALYERKYKKKLITNSiypqdpitgkPFY-NPHGKYSIKIYFNGVARKVIIDDKLPVdINGNLLC 446
                   577665899********98659*******99888765544433333332444455542233.468************************889***** PP

  Peptidase_C2 120 vksaeknefWsalleKAyAklhgsyealkggstsealedftggvtesiel..............................elkeapkelfkilkkal 186
                     s++ +efW +l+eKAy k++g y+   g ++   l  +tg + e +++                              +                
    EFC37118.1 447 SYSTKMEEFWISLMEKAYMKVNGGYQ-FPGSNSGIDLYALTGWIPEEVKIilnnnnntsingnnntssingnnnnnntckS---------------- 526
                   *************************9.67777777899***********96655555544443333333332222222220................ PP

  Peptidase_C2 187 ergslmgcsie....................ass..........................aeeleaklengLvkgHaYsvtaveevelkkek 232
                                                    +                          + +++++   gL ++HaY++++v+e++l+++ 
    EFC37118.1 527 ----------PnmmmmnngtqqypinnqqqvN-TfdkellwkrmhdgfqlgkclitistgHLDKQTEELVGLYANHAYAILDVREIKLNTSP 607
                   ..........1233333333344444333330.0333444444444444444444444334444445568***************9987655 PP

  == domain 3  score: 40.0 bits;  conditional E-value: 1.2e-14
  Peptidase_C2 229 kkekvkLirlrnPWGeveWkGawsdkske.Weevseeekekl.....klkkkedgefwmsfedflknFtkle 294
                   +++  +Li+++nPW ++ WkG++s   k+ W+   ++ k++l      ++++++g fwm++e +lk+F++++
    EFC37118.1 658 NNNIKRLIKVKNPWTKKGWKGPYSPYDKQiWT---DKLKKELeydasISHQEDNGIFWMNYESLLKYFQTVH 726
                   556779******************87665594...4555555333343467799***************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (925 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2254  (0.125718); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.93u 0.34s 00:00:01.27 Elapsed: 00:00:00.54
# Mc/sec: 5147.18
//
Query:       EFC37119.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-32  111.0   0.0    1.1e-31  110.3   0.0    1.3  1  SQS_PSY   Squalene/phytoene synthase


Domain annotation for each model (and alignments):
>> SQS_PSY  Squalene/phytoene synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  110.3   0.0     6e-36   1.1e-31      26     254 ..      52     323 ..      33     333 .. 0.91

  Alignments for each domain:
  == domain 1  score: 110.3 bits;  conditional E-value: 6e-36
                 HHHHHHHHT-.-----........------------..---------TH..........................................HHHHHHHH CS
     SQS_PSY  26 lYafcreaddlvDdvseplqararldwwrdavdavyaedklkpprepvl..........................................ralaqlir 82 
                 l  ++ e+++++D +++p  +  rl+ww+d+v++++    + ppr pvl                                          ++   ++ 
  EFC37119.1  52 LFCLNAELATIKDFTKTPSTGLLRLSWWKDQVKNAL---VGLPPRVPVLmalsfmqvnyfnkgftclndnyqqeqeqsnintsttsnttgsTSTTSTQN 147
                 5557899*****************************...999******99************************************9999999999988 PP

                 HHT--HHHHHHHHHHTS--SS-..--SHHHHHHHHHHHHHHHHHHHHHHH-S.S-HHHHHHHHHHHHHHHHHHHHHT---SHHHHTT..S-HHHHHHHT CS
     SQS_PSY  83 tyklpkellleliegmeadleftryetlddLeeYcyrvagvVgelclrllgarrsdralaeaarrlGkalQltnilRdvpeDaergrvyLPadvlkefg 181
                    l   +l+ + + +e dl  ++ +tl+d e Y++ v+++++   l+   + r++ ++++ a++lG++ ++  +lR+vp   e++  yLPa++ +++g
  EFC37119.1 148 NNSLKFSHLRNIFKWREVDLKWKQPATLADIESYSEGVYSTLIMSHLQCSKY-RDV-HTDHVASHLGRSYGICTLLRSVPHLSEHQSTYLPAQLCAKYG 244
                 899******************99999**************************.677.68**************************************** PP

                 --HHHHHHT-.-SHHHHHHHHHHHHHHHHHHHHHHHTGGG.........S.-HHHHHHHHHHHHHHHHHHHHHHHTTT-TTT CS
     SQS_PSY 182 vseedllrkgvrsaelrallrrlaerArelldearellkq.........lpdrrarpalllavalyrailerieaadydvls 254
                 ++e+d+++++ +s el+++++++a+ A+ +ld arel +          + +++a p  +++  +++  le++e+ ++++++
  EFC37119.1 245 ITEDDIYKHQ-NSHELEEVVFKVADLAKSHLDLARELADLkdektnkllV-NPKAYPL-FMTSIVCEVFLEKLEKVNFNIFH 323
                 *******998.6666*************************9999999955.6666665.999999999******99999554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1210  (0.0674884); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2180.49
//
Query:       EFC37120.1  [L=450]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-21   75.7   1.8    2.6e-20   72.3   0.1    3.0  2  Thioredoxin    Thioredoxin
    0.00014   22.0   0.2    0.00076   19.6   0.1    2.3  2  Thioredoxin_7  Thioredoxin-like
     0.0019   18.5   2.5        0.5   10.7   0.1    3.8  2  Thioredoxin_8  Thioredoxin-like
     0.0028   18.1   0.2        0.1   13.0   0.2    2.8  1  Thioredoxin_2  Thioredoxin-like domain
  ------ inclusion threshold ------
       0.04   14.1   0.2        0.2   11.8   0.0    2.2  2  Fib_alpha      Fibrinogen alpha/beta chain family
      0.091   12.7   0.1        3.2    7.7   0.0    2.5  2  YugN           YugN-like family


Domain annotation for each model (and alignments):
>> Thioredoxin  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1      0.12   3.6e+02       5      24 ..     146     165 ..     142     232 .. 0.78
   2 !   72.3   0.1   8.8e-24   2.6e-20      12     101 ..     359     446 ..     348     448 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.12
                  SSHHHHHHHHTTTSSEEEEE CS
  Thioredoxin   5 ltkenFeeevakekklvlve 24 
                  ++ ++F+e v+++kk+v+v 
   EFC37120.1 146 IVYDTFDEIVMDSKKDVFVA 165
                  56678999999999999885 PP

  == domain 2  score: 72.3 bits;  conditional E-value: 8.8e-24
                  HHHTTTSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTTTSEEEEEETTTSHHHHHHTT-SSSSEEEEEETTEEEEEEESS-HHHHHHHHH CS
  Thioredoxin  12 eevakekklvlveFyApwCghCkalaPeleklaeelkdkvklakvdvdenedlakkyevegiPtlklfkngkevkkyegarekeklaafl 101
                  +   +  ++v+v+F+A+wCg+C+a+aP +  l++  + ++ ++kvd+de+++ +k ++v+g+Pt+k fk  + v+ + g+   + l++++
   EFC37120.1 359 SYYLERYEKVIVDFTATWCGPCQAIAPLFGYLSSIEQ-DIIFLKVDADECQEQCKAFNVDGFPTFKSFKGKNMVQVIIGSDL-KGLKKMV 446
                  555556789*********************9987666.******************************99998888888755.6666655 PP

>> Thioredoxin_7  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.1   3.2e+03      52      82 ..     189     220 ..     169     221 .. 0.49
   2 !   19.6   0.1   2.5e-07   0.00076      15      77 ..     363     421 ..     353     426 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.1
                    T-EEEEESS--S-GGG..-TT---SSEEEEE- CS
  Thioredoxin_7  52 kfvllrvdvterdani.leldeqgvPvvafld 82 
                    + v  r +   +d ++ + ++e ++P + f+ 
     EFC37120.1 189 NLVIGRMNSAYNDYSLeYFPKEKYFPKLTFFS 220
                    33333333333444334333458899998885 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 2.5e-07
                    HHT--EEEEE--TT-HHHHHHHHHHHH-HHHHH.HHHT-EEEEESS--S-GGG.-TT---SSE CS
  Thioredoxin_7  15 ergkpvlvffgaswcftCqalerdflsdeevkaalaekfvllrvdvterdanileldeqgvPv 77 
                    er   v+v+f+a+wc++Cqa++  f    +    + +++++l+vd +e +++  ++  +g+P+
     EFC37120.1 363 ERYEKVIVDFTATWCGPCQAIAPLFGYLSS----IEQDIIFLKVDADECQEQCKAFNVDGFPT 421
                    67778*****************99966644....66699999999999998773333356665 PP

>> Thioredoxin_8  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1     0.032        95      32      72 ..      50      95 ..      27     106 .. 0.68
   2 !   10.7   0.1   0.00017       0.5       4      46 ..     368     405 ..     365     449 .. 0.72

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.032
                   H...TTSEEEEEEE-SS-HHHHHHHGGGS..-TTSEE.EE-TT-HH CS
  Thioredoxin_8 32 k...kkkveivyvsldkkeeefekylkkn..kkpwlsvpfddkkrn 72
                   +   + +++++   +d++  + + +++k+  +k+ +++ f++k+r+
     EFC37120.1 50 DswlRTNFNFIKSDMDRESIQGKLHFAKDakPKTIMAFKFPSKERY 95
                   2455788999999999999999*******43335555556666554 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00017
                    EEEEE--SSSHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-SS- CS
  Thioredoxin_8   4 vlLyfgaswcppckaftpklkelyeklkkkkkveivyvsldkk 46 
                    v++ f a+wc pc+a+ p    l ++++  +   i+++++d +
     EFC37120.1 368 VIVDFTATWCGPCQAIAPLFGYL-SSIE--Q--DIIFLKVDAD 405
                    89**************9976443.4444..3..3444444443 PP

>> Thioredoxin_2  Thioredoxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.2   3.5e-05       0.1       7      98 ..     367     436 ..     363     438 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.5e-05
  Thioredoxin_2   7 pvlvvftdpdCpyCkklkkelkelddvtvrvllfplkpsfepkavaiwcakekkkafkdieenvelarkygvrgtPtivfldgkeivarlpG 98 
                    +v+v+ft+++C+ C+++   l+ +    +      ++++  +++ +++ ++ +           e  ++++v+g+Pt+  + gk++v ++ G
     EFC37120.1 367 KVIVDFTATWCGPCQAIAP-LFGY---LSS-----IEQD--IIFLKVDADECQ-----------EQCKAFNVDGFPTFKSFKGKNMVQVIIG 436
                    79**************877.4444...122.....4555..555555555554...........5688899999999999999977777655 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       1.1   3.2e+03      61     110 ..     247     294 ..     235     301 .. 0.51
   2 ?   11.8   0.0   6.7e-05       0.2      39     133 ..     320     412 ..     311     414 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.1
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHH CS
   Fib_alpha  61 ikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnv 110
                 i++s ++k   +k   + ++++ +el   i + k  + + e+n++ ++++
  EFC37120.1 247 IHESCTHKFDMEKY-LEQVTQY-DELAALIDECKLAVWKVENNLHSIRSI 294
                 55555444444442.2222222.234445556666666666666666655 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 6.7e-05
                 CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT CS
   Fib_alpha  39 kleneleeisnstkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesneqkiqkLeqdidqkerkCk 133
                 k+++ le+i++   + ++++  ++++ + k  + k  ++v + + ++ e+ i+++ +t    ++ i  L + l+s eq+i  L++d d+ +++Ck
  EFC37120.1 320 KMKELLEKIKS--VSLQDMIDLLEQYKAGKTIHLKADETVDSYYLERYEKVIVDFTATWCGPCQAIAPLFGYLSSIEQDIIFLKVDADECQEQCK 412
                 67778887764..456777887877777777777766666777788999999************************************9999998 PP

>> YugN  YugN-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.0    0.0011       3.2      38      68 ..      40      70 ..      12      78 .. 0.88
   2 ?    2.4   0.0     0.044   1.3e+02      37      86 ..     150     200 ..     113     244 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0011
        YugN 38 fDyklddeagyvflRlPfqavdGeldskdav 68
                 D+ +d++a+  +lR  f+ ++ ++d+++++
  EFC37120.1 40 IDQMIDEQAEDSWLRTNFNFIKSDMDRESIQ 70
                5999**********************98765 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.044
        YugN  37 yfDyklddeagyvflRlPfq.avdGeldskdavvklgrpfllshvyqegld 86 
                 +fD  + d+++ vf+ l f+ +++G++ s+ a +  ++p l+   +++  +
  EFC37120.1 150 TFDEIVMDSKKDVFVALCFNeTLEGNFISTMAKILQNEPNLVIGRMNSAYN 200
                 6999999999*********72569*99999999999999887666665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (450 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       790  (0.0440627); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2787.12
//
Query:       EFC37121.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.3e-13   50.7   0.1    6.3e-13   49.3   0.1    1.7  1  GyrI-like  GyrI-like small molecule binding domain
    0.00013   22.2   0.2     0.0041   17.3   0.2    2.1  1  Cass2      Integron-associated effector binding protein


Domain annotation for each model (and alignments):
>> GyrI-like  GyrI-like small molecule binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.3   0.1   7.1e-17   6.3e-13       3     154 ..      10     171 ..       8     172 .. 0.74

  Alignments for each domain:
  == domain 1  score: 49.3 bits;  conditional E-value: 7.1e-17
                 EEEEEE--EEEEEEEEEEEHCCCHHHHHHHHHHHHHHHHHHCTT...--SSEEEEEEEEE-STTCCCEEEEEEEECCCCC..........CGBTTSEEE CS
   GyrI-like   3 veivelpafrvvgirhrgdyneeggipklweelyawaseiklsn...avspligvssdepeetedeelkydigvtveirv..........egpeglefl 88 
                 ++i++lpa++ +g+r+       g +pk + e+   +s    +    +v  +  ++s  + ++ ++ l +d    ++ ++          ++    +  
  EFC37121.1  10 IKIITLPAKKYLGVRRNNISIADGDFPKWIKEASRLISPVLNRTcypTVTAFPRFVSPQD-ADIEHLLFVDQELSIDSDLvnrvensqpnDEGLKAQLS 107
                 789999999999998754444433355555555544444444434445555555555543.55666666666666665559999999966666677889 PP

                 EE-SEEEEEEEEECEGGGHHHHHHHHHHTHHHHTT-EEEESEEEEEEECCCTS.SCGCEEEEEEEEE CS
   GyrI-like  89 eipageyAvfrhkGpyddlqatyaklygewlpesgyerrdgpsiEiYlsdpre.reeelkteiyipv 154
                 e+p geyA fr+ Gpy++l  +++kl++   + sgy  + +p+ E Y +d+ + ++eel t++y+ +
  EFC37121.1 108 EMPSGEYAYFRYVGPYEGLSSVWNKLMK--EKLSGY-VHTEPCWEEYINDCTQvKKEELITDLYWKL 171
                 ****************************..999***.***************************876 PP

>> Cass2  Integron-associated effector binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.2   4.5e-07    0.0041      84     137 ..     106     155 ..      11     169 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 4.5e-07
                 EEEE--EEEEEEEEESSSTT-HHHHHHHHHHCHCCHCTEEE-SSEEEEEESTTH CS
       Cass2  84 kkeiPggkYavftiegdfeedlaeaweaiygellpnsnyerrggpdfEvykeep 137
                   e P+g+Ya f   g+ e  l+ +w+++++e l  s+y +++ p+ E+y ++ 
  EFC37121.1 106 LSEMPSGEYAYFRYVGPYEG-LSSVWNKLMKEKL--SGYVHTE-PCWEEYINDC 155
                 4599***************9.************9..6998866.9999996544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       304  (0.0169558); expected 358.6 (0.02)
Passed bias filter:                      262  (0.0146132); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 1028.36
//
Query:       EFC37122.1  [L=415]
Description: hypothetical protein NAEGRDRAFT_81999 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (415 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2094  (0.116794); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 2407.17
//
Query:       EFC37123.1  [L=738]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.8e-11   42.9   0.8    3.6e-05   23.7   0.3    3.7  4  TFIIB          Transcription factor TFIIB repeat
  ------ inclusion threshold ------
      0.047   13.5   0.4       0.11   12.3   0.4    1.6  1  HTH_IclR       IclR helix-turn-helix domain
       0.13   12.3   1.2       0.27   11.3   1.2    1.5  1  DZR            Double zinc ribbon
        0.3   11.2   4.3        9.6    6.3   1.4    2.7  2  ArfGap         Putative GTPase activating protein for Arf
       0.33   10.5   3.3       0.18   11.4   0.7    2.0  2  TF_Zn_Ribbon   TFIIB zinc-binding
        1.2    8.6   4.2        3.9    7.0   0.2    2.4  2  zf-ribbon_3    zinc-ribbon domain
        1.5    8.6   4.1        8.1    6.3   0.2    2.3  2  zinc_ribbon_2  zinc-ribbon domain


Domain annotation for each model (and alignments):
>> TFIIB  Transcription factor TFIIB repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   8.9e-06     0.023      34      64 ..     315     345 ..     306     352 .. 0.88
   2 ?   -2.7   0.0       2.5   6.3e+03      52      67 ..     351     366 ..     348     368 .. 0.83
   3 !   23.7   0.3   1.4e-08   3.6e-05      20      71 .]     408     459 ..     395     459 .. 0.92
   4 ?   -1.1   0.0      0.78     2e+03      51      69 ..     678     696 ..     676     697 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 8.9e-06
                 GCTTHHHTTHHHHHHTTTTSS--HHHHHHHS CS
       TFIIB  34 rspagiaAAclyiAcrkeevkrtqkeissvl 64 
                 + ++g++A +ly+ cr+e++  t+ + s+v+
  EFC37123.1 315 KWMDGVIAGALYVVCRREKLPITLLDLSEVT 345
                 6689********************9999986 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.5
                 TSS--HHHHHHHSS-- CS
       TFIIB  52 evkrtqkeissvlqVs 67 
                 e+ r  kei+++ +++
  EFC37123.1 351 ELGRKYKEICKTFNIQ 366
                 678999****999886 PP

  == domain 3  score: 23.7 bits;  conditional E-value: 1.4e-08
                 HHHHHHTTSTTTTSGCTTHHHTTHHHHHHTTTTSS--HHHHHHHSS--SHHH CS
       TFIIB  20 elaklaleekvlkGrspagiaAAclyiAcrkeevkrtqkeissvlqVsekti 71 
                  +++ a++e + +Gr+p++++AA+l++A + +     ++e++  ++V e ti
  EFC37123.1 408 RIIRVAMKECLDSGRRPIALVAAALLLALQSCSIDMKLSEVARSTHVGEATI 459
                 678889999999*************************************998 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 0.78
                 TTSS--HHHHHHHSS--SH CS
       TFIIB  51 eevkrtqkeissvlqVsek 69 
                 +   r+ +ei++++ ++e+
  EFC37123.1 678 NDIMRSKEEIAALVGIREE 696
                 56789*********99986 PP

>> HTH_IclR  IclR helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.4   4.3e-05      0.11       5      37 ..     429     461 ..     426     469 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.3e-05
                 HHHHHCT-CTTBSS-BHHHHHHHHTS-HHHHHH CS
    HTH_IclR   5 alaiLdalaeapqeltlselArrtglpkStvhR 37 
                 a+a+L al ++  +++lse+Ar t++  +t + 
  EFC37123.1 429 AAALLLALQSCSIDMKLSEVARSTHVGEATIRE 461
                 89***********************99999876 PP

>> DZR  Double zinc ribbon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.2    0.0001      0.27      14      41 ..      48      79 ..      44      82 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.0001
         DZR 14 fCseCgtklkavaa....edrCpsCgekvdpe 41
                 C++Cg++ +  ++     ++C++Cg++v++ 
  EFC37123.1 48 SCKHCGASSEYIESdefnYEVCSKCGTQVTSS 79
                69999999865555888899999999998765 PP

>> ArfGap  Putative GTPase activating protein for Arf
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.013        33      14      85 ..      47     119 ..      39     154 .. 0.67
   2 ?    6.3   1.4    0.0037       9.6      60     114 ..     264     317 ..     258     319 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.013
                 CB-TTT-SBS--EEETTTTEEE-HHHHHHHCCS.TTT--EE.ETTTS---HHHHHHHHHTCHHHHHHHHTTTC CS
      ArfGap  14 kvCaDCgakeptWaslnlgvflCieCsgvHrslgvhiskvr.sltldkwedeelellkalgNkkaneileakl 85 
                   C  Cga++    s ++   +C++C     s ++ is  r +++ dk +++++    ++ +  + ++l a++
  EFC37123.1  47 GSCKHCGASSEYIESDEFNYEVCSKCGTQVTSSSQPISIFReEIEFDKDNSKKIGRHVSNDEGFFGAYLMATS 119
                 5799**9998888888**********99999999999887734777775555555444444444444444444 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0037
                 ---HHHHHHHHHTCHHHHHHHHTTTC-TTTSG-TTCGHHHHHHHHHHHHTCHTTC CS
      ArfGap  60 kwedeelellkalgNkkaneileaklpkeekrskssskekreefirakYeekkfa 114
                 k+ed+  e   +l  ++++++l +++++e+   k++++++ +++i+ kY+++k++
  EFC37123.1 264 KFEDDPREHSLNLMKQRFQSTLLSTKQQEKTT-KKEEESESSDIIKFKYTKEKWM 317
                 56666666666777788888888887555555.99999**************997 PP

>> TF_Zn_Ribbon  TFIIB zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.7   6.9e-05      0.18       3      29 ..      49      76 ..      47      88 .. 0.75
   2 ?   -3.3   0.1       2.6   6.6e+03       6      23 ..     360     377 ..     359     378 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 6.9e-05
                  ETTTTCEE.CHEETSTTCE.EESSSSBEE CS
  TF_Zn_Ribbon  3 CPnCgstn.lveDpergel.vCtdCGlVl 29
                  C+ Cg ++ +  + ++ ++ vC++CG+ +
    EFC37123.1 49 CKHCGASSeY-IESDEFNYeVCSKCGTQV 76
                  *****97744.333445566******977 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.6
                   TTCEECHEETSTTCEEES CS
  TF_Zn_Ribbon   6 CgstnlveDpergelvCt 23 
                   C++ n+ +Dp   e++C 
    EFC37123.1 360 CKTFNIQVDPLDLETLCD 377
                   887668999999999995 PP

>> zf-ribbon_3  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.7     0.042   1.1e+02      16      24 ..      46      54 ..      45      55 .. 0.78
   2 ?    7.0   0.2    0.0015       3.9       4      16 ..      68      81 ..      65      83 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.042
  zf-ribbon_3 16 dnvCpyCGt 24
                 d  C++CG+
   EFC37123.1 46 DGSCKHCGA 54
                 557****96 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0015
  zf-ribbon_3  4 rCPnCGa.plssdd 16
                  C++CG+ + ss++
   EFC37123.1 68 VCSKCGTqVTSSSQ 81
                 6******6666555 PP

>> zinc_ribbon_2  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   4.5     0.011        28       2      22 ..      49      75 ..      48      76 .. 0.79
   2 ?    6.3   0.2    0.0032       8.1       2      10 ..      69      77 ..      68      81 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.011
  zinc_ribbon_2  2 CpnCGaelq..dnakF....CpyCGtp 22
                   C++CGa  +  + + F    C++CGt 
     EFC37123.1 49 CKHCGASSEyiESDEFnyevCSKCGTQ 75
                   899998875567888888999999996 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0032
  zinc_ribbon_2  2 CpnCGaelq 10
                   C++CG+++ 
     EFC37123.1 69 CSKCGTQVT 77
                   888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (738 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1151  (0.0641977); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.80u 0.31s 00:00:01.11 Elapsed: 00:00:00.53
# Mc/sec: 4180.13
//
Query:       EFC37124.1  [L=474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       501  (0.0279436); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 2809.76
//
Query:       EFC37125.1  [L=252]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0039   16.9  21.6       0.34   10.9   6.8    3.0  2  AT_hook   AT hook motif
  ------ inclusion threshold ------
        6.5    7.5  15.2          2    9.2   3.5    3.3  3  RBR       RNA binding Region


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   6.9   4.7e-05      0.42       1      12 [.      31      42 ..      31      43 .. 0.88
   2 !   10.9   6.8   3.8e-05      0.34       1      11 [.     109     119 ..     109     120 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 4.7e-05
     AT_hook  1 kRkRGRPrKaat 12
                ++kRGRP+K++ 
  EFC37125.1 31 PKKRGRPPKKKQ 42
                79*******985 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 3.8e-05
     AT_hook   1 kRkRGRPrKaa 11 
                 ++kRGRP+K++
  EFC37125.1 109 PKKRGRPPKNS 119
                 79*******97 PP

>> RBR  RNA binding Region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   3.5   0.00022         2      26      52 ..      24      44 ..      10      52 .. 0.73
   2 ?    5.1   0.7    0.0043        39      37      48 ..     107     118 ..      87     130 .. 0.71
   3 ?   -0.9   0.1      0.32   2.8e+03      30      41 ..     228     240 ..     197     240 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00022
         RBR 26 kaaaaakneppkipKKRGpKPGsKrKp 52
                k+      +++  pKKRG+ P++K + 
  EFC37125.1 24 KN------KNNNSPKKRGRPPKKKQQE 44
                22......78899*********99654 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0043
         RBR  37 kipKKRGpKPGs 48 
                   pKKRG+ P++
  EFC37125.1 107 DLPKKRGRPPKN 118
                 567777776653 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.32
         RBR  30 aakn...eppkipKK 41 
                    n    + k+p+K
  EFC37125.1 228 N--NnntSNYKPPRK 240
                 1..134677777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (252 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1705  (0.0950973); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1624.79
//
Query:       EFC37126.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       582  (0.0324614); expected 358.6 (0.02)
Passed bias filter:                      235  (0.0131073); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 1147.52
//
Query:       EFC37127.1  [L=154]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-22   79.2   0.3    2.4e-14   53.5   0.0    2.4  3  Ank_4     Ankyrin repeats (many copies)
    1.3e-17   64.1   0.0    1.8e-17   63.7   0.0    1.2  1  Ank_2     Ankyrin repeats (3 copies)
    5.1e-16   58.5   0.0    2.7e-07   30.7   0.0    2.2  2  Ank_5     Ankyrin repeats (many copies)
      6e-09   36.0   0.0     0.0076   16.7   0.0    2.7  3  Ank       Ankyrin repeat
    9.9e-09   34.8   0.0    0.00078   19.7   0.0    2.9  3  Ank_3     Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.0   0.1   2.8e-09     1e-05       5      55 .]      21      72 ..      17      72 .. 0.83
   2 !   53.5   0.0   6.8e-18   2.4e-14       2      55 .]      53     106 ..      52     106 .. 0.97
   3 !    8.8   0.0   0.00068       2.4      12      42 ..      97     126 ..      96     127 .. 0.91

  Alignments for each domain:
  == domain 1  score: 26.0 bits;  conditional E-value: 2.8e-09
       Ank_4  5 LhyaaisgrlelvrlLlek..gadinaqdnrsGetalhiAakrgnveilklLl 55
                +++aa+ g++  ++ Ll+   + +  a  ++ G++alh Aa  g+++++k+L+
  EFC37127.1 21 YFSAAKRGQVLEIQELLQEdpKFNTGAL-DEFGNNALHWAAGAGHLDCVKFLV 72
                799999***********65144555555.**********************96 PP

  == domain 2  score: 53.5 bits;  conditional E-value: 6.8e-18
       Ank_4   2 ltaLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55 
                 + aLh+aa +g+l++v++L+e+ + +i+a  n++G+t+lh+A +rg ++++k+L+
  EFC37127.1  53 NNALHWAAGAGHLDCVKFLVETvKLSIDAI-NKQGDTPLHKATWRGALDVVKYLV 106
                 679**************************8.**********************96 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00068
       Ank_4  12 grlelvrlLlekgadinaqdnrsGetalhiA 42 
                 g l++v++L+ek+a ++ + n++   +++ A
  EFC37127.1  97 GALDVVKYLVEKDAKLDVV-NGQKKRPVDLA 126
                 779****************.**999998876 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.7   0.0     5e-21   1.8e-17       4      81 ..      24     114 ..      21     116 .. 0.79

  Alignments for each domain:
  == domain 1  score: 63.7 bits;  conditional E-value: 5e-21
       Ank_2   4 Aakngnl.elvklLlegadpn....k.ngktaLhyAakngnleivklLleh.......adndgrtpLhyAarsghleivklLlekgadinl 81 
                 Aak g+  e+ +lL e  ++n    + +g++aLh+Aa +g+l++vk+L+e        ++++g tpLh A + g l++vk+L+ek+a++++
  EFC37127.1  24 AAKRGQVlEIQELLQEDPKFNtgalDeFGNNALHWAAGAGHLDCVKFLVETvklsidaINKQGDTPLHKATWRGALDVVKYLVEKDAKLDV 114
                 788886635555555444444545538**********************96667866677***********99***********9998775 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.7   0.0   7.6e-11   2.7e-07       1      36 [.      36      72 ..      36      77 .. 0.94
   2 !   25.9   0.0   2.4e-09   8.6e-06       9      56 .]      79     126 ..      73     126 .. 0.88

  Alignments for each domain:
  == domain 1  score: 30.7 bits;  conditional E-value: 7.6e-11
       Ank_5  1 Llehg.padvnrldgggntpLhvAakygaadvvrlLl 36
                Ll+++   ++ +ld++gn++Lh+Aa +g++d+v++L+
  EFC37127.1 36 LLQEDpKFNTGALDEFGNNALHWAAGAGHLDCVKFLV 72
                89999999****************************8 PP

  == domain 2  score: 25.9 bits;  conditional E-value: 2.4e-09
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLlargadlnltdsrGltaldlA 56 
                 +++ ++ g tpLh A ++ga+dvv++L++  a l++ +++ + ++dlA
  EFC37127.1  79 IDAINKQGDTPLHKATWRGALDVVKYLVEKDAKLDVVNGQKKRPVDLA 126
                 566677777*****************************9999999988 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.2   4.3e+03       9      22 ..      24      37 ..      18      48 .. 0.76
   2 !   16.7   0.0   2.1e-06    0.0076       2      22 ..      52      72 ..      51      84 .. 0.85
   3 !   16.2   0.0   2.9e-06      0.01       2      31 ..      86     116 ..      85     116 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.2
                HHHHTTHHHHHHHH CS
         Ank  9 AatngkkriiklLL 22
                Aa +g++  i++LL
  EFC37127.1 24 AAKRGQVLEIQELL 37
                67778777788888 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 2.1e-06
                SBBHHHHHHHHTTHHHHHHHH CS
         Ank  2 GnTPLHlAatngkkriiklLL 22
                Gn +LH+Aa  g+++++k+L+
  EFC37127.1 52 GNNALHWAAGAGHLDCVKFLV 72
                99*******99********97 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 2.9e-06
                 SBBHHHHHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   2 GnTPLHlAatngkkriiklLL.hGAnlnald 31 
                 G+TPLH A ++g ++++k+L+ + A l+ ++
  EFC37127.1  86 GDTPLHKATWRGALDVVKYLVeKDAKLDVVN 116
                 9******999999********7778888765 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.1   3.8e+03       9      27 ..      24      41 ..      22      45 .. 0.69
   2 !   19.7   0.0   2.2e-07   0.00078       2      23 ..      52      73 ..      51      81 .. 0.86
   3 !   11.6   0.0   9.2e-05      0.33       2      30 ..      86     113 ..      85     114 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.1
       Ank_3  9 Aarsgnl.eivkfLlenkga 27
                Aa+ g + e ++ Ll+   +
  EFC37127.1 24 AAKRGQVlE-IQELLQ-EDP 41
                777777745.999999.455 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 2.2e-07
       Ank_3  2 GetpLhlAarsgnleivkfLle 23
                G+++Lh+Aa +g+l+ vkfL+e
  EFC37127.1 52 GNNALHWAAGAGHLDCVKFLVE 73
                9********************9 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 9.2e-05
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadvn 30 
                 G tpLh A   g l++vk+L+e k a ++
  EFC37127.1  86 GDTPLHKATWRGALDVVKYLVE-KDAKLD 113
                 89********************.888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.43u 0.27s 00:00:00.70 Elapsed: 00:00:00.44
# Mc/sec: 1056.45
//
Query:       EFC37128.1  [L=682]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.3e-40  137.5   7.1    1.1e-39  136.5   7.1    1.6  1  UCH           Ubiquitin carboxyl-terminal hydrolase
    7.7e-11   42.1   7.5    7.7e-11   42.1   7.5    2.4  2  UCH_1         Ubiquitin carboxyl-terminal hydrolase
  ------ inclusion threshold ------
      0.011   16.1   3.3      0.055   13.9   3.3    2.3  1  TSNAXIP1_N    Translin-associated factor X-interacting N-term
      0.024   14.2   1.0        1.2    8.8   0.3    3.4  3  VASP_tetra    VASP tetramerisation domain
        2.3    8.3   7.9        5.9    6.9   0.3    3.6  3  Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C
        4.2    7.4  10.5         20    5.3   8.8    2.9  2  TPR_MLP1_2    TPR/MLP1/MLP2-like protein


Domain annotation for each model (and alignments):
>> UCH  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  136.5   7.1   3.7e-43   1.1e-39       1     257 []     100     546 ..     100     546 .. 0.89

  Alignments for each domain:
  == domain 1  score: 136.5 bits;  conditional E-value: 3.7e-43
                 -EES-SSSTHHHHHHHHHHHTSHHHH.HHHHTCHHCCSSTCCCCC-.TT.TTS.TTH............HHHHHHHHHHHHHSH-CCEE--HHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH   1 tGlsNlGntCymnsvlQcLfsipelr.dyllsleevkkesrnkkelnesnplgkkge............lakalkdlfkellkskskavsPkklkktls 86 
                 +Gl+N+GntCy+n++lQ++f+ip+   ++++++ + +k ++  ++++ ++ +++++             ++++l++lf+++l s+++ v P+ +++ l+
  EFC37128.1 100 VGLKNIGNTCYVNALLQSYFMIPSVLkSIMKTKPSAQKPNSSPEDVQMTEANQTQDAslahldeessieFLQSLQKLFASMLLSNTNFVDPSPVMQKLK 198
                 69*********************998566666555555555666666666555555368899999*****************999**********9999 PP

                 HHSGG.GTSSSTCEHHHHHHHHHHHHHHHHCCHCCCHHH.HHHCCCTTSHHHHHH-EEEEE...................................... CS
                 xxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxx...................................... RF
         UCH  87 klaks.fsgykqqDaqEflaflLdqlhedlnrevaeekw.kkhlkrndslitdlfegqlks...................................... 145
                   +++  +++++qD  Ef +  L++l++ ++         k++ ++ +   ++lf+g++                                        
  EFC37128.1 199 DAENKpYKIGEMQDLPEFNSLFLSRLEKGMET------LhKESRENISAKFKELFYGKTAVfveaeeldhtkiekktidtfnhlilpisqdtrnymdaf 291
                 888777************************99......42445555556689999999999999999999999999999999999999*********** PP

                 ..........................EEEEEEB-SEEEEEEESEEETEE.EEE--SEEB--SEEE-GGGBSS-BTTS-TCS-B................ CS
                 ..........................xxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................ RF
         UCH 146 ..........................klklkrlPeiLiihlkRfsynss.ksKlntkvefpeeldlssylaeekkkkteekkk................ 201
                                               +++P++L+++ +R  y  +  +K++++++ p +l+l +yl ++k+  +  + k                
  EFC37128.1 292 elcmkddmieyttdkshktkarktmwFDGKDSVPPVLFLQTSRAVYGTNtLTKIQNSIDLPFDLNLGPYLLHNKEITEGIRSKlkvlnqelehvdrrlk 390
                 *********************99777666689**************88889******************9977776665555599************** PP

                 ...........................................................................................EEEEEEEE CS
                 ...........................................................................................xxxxxxxx RF
         UCH 202 ...........................................................................................YeLiavvv 209
                                                                                                            Y+L+++++
  EFC37128.1 391 sflesyenrdfgliqafevcsnrlfeirheyeeqlsssnannidhfsiaiqvlqqqqenmtrrvselkekrdsllnqiekvwevqypqeltYNLYSIIM 489
                 *************************************************************************************************** PP

                 EES.CTTSEEEEEEEE.CTTTTEEEEEETTEEEEE-HHCCCTT.......CEEEEEE CS
                 xxx.xxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx.......xxxxxxx RF
         UCH 210 HsG.slssGHYvayik.nekngkWykydDetvkevkeeeevls.......sayiLfY 257
                 HsG s+ +GHY++yik + ++  W+k++D+ v+ +++e+ +++       say L+Y
  EFC37128.1 490 HSGsSALGGHYWSYIKyQGDDDTWFKFNDTIVTTLTKEDVIREafktksnSAYCLIY 546
                 ***99***********6667778*************99433335555679*****99 PP

>> UCH_1  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       1.9   5.6e+03     238     258 ..      48      68 ..      10      82 .. 0.58
   2 !   42.1   7.5   2.6e-14   7.7e-11       1     319 [.     100     520 ..     100     521 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.9
                 xxxxxxxxxxxxxxxxxxxxx RF
       UCH_1 238 nwlpleiklsldedknleekl 258
                 + l + i++sld+dk +++++
  EFC37128.1  48 TELARAIQISLDQDKASNNNN 68 
                 344444555555444332222 PP

  == domain 2  score: 42.1 bits;  conditional E-value: 2.6e-14
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....... RF
       UCH_1   1 sGLEnhivnsYlNslLQvlyfipplrnlalshlakeckkehcLlcElgflf.dmldkakglncqasnFlralssipeasalglileeeeete....... 91 
                 +GL n  +++Y+N+lLQ +++ip + + +++    + +k ++   ++++   + +++a+ ++  ++   + l+s+++  a  l+ + +           
  EFC37128.1 100 VGLKNIGNTCYVNALLQSYFMIPSVLKSIMKTK-PSAQKPNSSPEDVQMTEaNQTQDASLAHLDEESSIEFLQSLQKLFASMLLSNTN---Fvdpspvm 194
                 8*********************99997666544.566666666666666554666777766777776666666666655666653333...13344666 PP

                 ......xxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxx..xxxxxxxxxxxx RF
       UCH_1  92 ......kssaislssliq..sfnrflldqlekelketkkns.seeesaieqllgtkaettirclkCgsek.srksstlvldlkyP..kpsnekkeakvt 178
                       ++++ ++ ++++  +fn  +l++lek  ++ +k+s ++ ++++++l+  k+   ++  +  ++k ++k++   + l+ P  +     ++    
  EFC37128.1 195 qklkdaENKPYKIGEMQDlpEFNSLFLSRLEKGMETLHKESrENISAKFKELFYGKTAVFVEAEELDHTKiEKKTIDTFNHLILPisQD---TRNYMDA 290
                 667666777788888888767***********9999888774555667999*************9999997777777777888896333...3344456 PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..............................xxxxxxxxxxxxxxx..xxxxxxxx......... RF
       UCH_1 179 fasilksslerekttrawCekCkryqpteqrktvk..............................nlPpvLalnakleee..eelelwkt......... 236
                 f+ ++k  + + +t ++   k ++  ++  + +v                               nl p L+ n++++e   ++l+++++         
  EFC37128.1 291 FELCMKDDMIEYTTDKSHKTKARKTMWFDGKDSVPpvlflqtsravygtntltkiqnsidlpfdlNLGPYLLHNKEITEGirSKLKVLNQelehvdrrl 389
                 888888888888888888888777777777777666666666666666666666666666666666666666666665443324444444888899999 PP

                 ...........................................xxxxxxxxxxxxxxxxxx..............xxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1 237 ...........................................knwlpleiklsldedknl..............eeklkeerekakaekeikvYeLqs 278
                                                             +    +i++++ +++++              +  ++ e+  + +  +  +Y+L s
  EFC37128.1 390 ksflesyenrdfgliqafevcsnrlfeirheyeeqlsssnannIDH--FSIAIQVLQQQQEnmtrrvselkekrdSLLNQIEKVWEVQYPQELTYNLYS 486
                 9999999999999999999999999999999999999887643123..344444433333357888888888887555555555566788999****** PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1 279 vvvhigdskesghLvslvkvaekelerdppesqWylFNDfl 319
                 +++h g+s   gh+ s++k +        +++ W++FND  
  EFC37128.1 487 IIMHSGSSALGGHYWSYIKYQG-------DDDTWFKFNDTI 520
                 ******8877*********733.......4679******75 PP

>> TSNAXIP1_N  Translin-associated factor X-interacting N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   3.3   1.8e-05     0.055      20      97 ..     386     469 ..     369     476 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.8e-05
  TSNAXIP1_N  20 ekrlqvyrevFed....lieefkaYkdlLseIKkEYelyiahllesqreaqylkakl.ktlsessdkraleleek.reelrale 97 
                   rl+ + e +e+    li+ f  + + L eI++EYe+ +++   +  + +  + ++ +  +e+ ++r+ el+ek +  l+++e
  EFC37128.1 386 DRRLKSFLESYENrdfgLIQAFEVCSNRLFEIRHEYEEQLSSSNANNIDHFSIAIQVlQQQQENMTRRVSELKEKrDSLLNQIE 469
                 344444444444322228***********************9998888888876666599999999*********444455555 PP

>> VASP_tetra  VASP tetramerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.2   6.6e+03      24      34 ..     365     375 ..     365     376 .. 0.83
   2 ?    1.6   0.0      0.07   2.1e+02       6      15 ..     558     567 ..     557     569 .. 0.90
   3 ?    8.8   0.3    0.0004       1.2       6      19 ..     585     598 ..     583     602 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.2
  VASP_tetra  24 eEIIeAirqEL 34 
                 +EI e ir+ L
  EFC37128.1 365 KEITEGIRSKL 375
                 59999999988 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.07
  VASP_tetra   6 rlKqEILeEv 15 
                 ++K EI++Ev
  EFC37128.1 558 SFKDEIVTEV 567
                 69*******9 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.0004
  VASP_tetra   6 rlKqEILeEvrkEL 19 
                 ++K EIL+E++k +
  EFC37128.1 585 KFKPEILQEMKKNF 598
                 8**********976 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.6   4.9e+03       3      28 ..     172     200 ..     170     246 .. 0.54
   2 ?    2.4   1.5     0.051   1.5e+02      10     102 ..     428     455 ..     360     484 .. 0.44
   3 ?    6.9   0.3     0.002       5.9      40      90 ..     605     656 ..     589     663 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.6
  Baculo_PEP_C   3 dvqqL....nggggnqfldLtnvLnairlq 28 
                    +q+L     ++++n f+d ++v++ ++  
    EFC37128.1 172 SLQKLfasmLLSNTN-FVDPSPVMQKLKDA 200
                   566666653344544.78888888888643 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.051
  Baculo_PEP_C  10 gggnqfldLtnvLnairlqnvqilaqlatlldaietqLnalsedlksllaeldtrldtlltnLtdalnalqdtlrneLtnlnsiltnLlssvt 102
                   +++n+                                                                  d ++ +++ l+++  n++  v 
    EFC37128.1 428 SNANNI-----------------------------------------------------------------DHFSIAIQVLQQQQENMTRRVS 455
                   222222.................................................................2222222222222222222222 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.002
  Baculo_PEP_C  40 ldaietqLnalsedlksllaeldtrldtlltnLtdalnalq.dtlrneLtnl 90 
                   +d++ ++++   +dl++++ e d +l ++l+ L+  +na + ++ +neL+++
    EFC37128.1 605 KDDMTNRIHLARSDLQNSSLEHDYKLRNFLSFLQCIINAASsEAAKNELNAI 656
                   6788999999******************************99*******987 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       4.7   1.4e+04     113     128 ..     211     226 ..     210     226 .. 0.88
   2 ?    5.3   8.8    0.0066        20      81     128 ..     423     470 ..     363     471 .. 0.82

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 4.7
  TPR_MLP1_2 113 edlneqNklLhdQlEs 128
                 +dl e N+l +++lE+
  EFC37128.1 211 QDLPEFNSLFLSRLEK 226
                 799999********95 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0066
  TPR_MLP1_2  81 esakaeleeseesweeqkeelekelselekriedlneqNklLhdQlEs 128
                 e+++++++++  + +   + l+++ +++++r+ +l+e+ + L++Q+E+
  EFC37128.1 423 EQLSSSNANNIDHFSIAIQVLQQQQENMTRRVSELKEKRDSLLNQIEK 470
                 455666666667777777899*************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (682 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1269  (0.0707792); expected 358.6 (0.02)
Passed bias filter:                      519  (0.0289475); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.75u 0.33s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 3812.11
//
Query:       EFC37129.1  [L=138]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.089   12.7   0.4       0.11   12.3   0.4    1.2  1  SPATA24     Spermatogenesis-associated protein 24
       0.14   12.3   0.7        3.1    8.1   0.1    2.2  2  GABP-alpha  GA-binding protein alpha chain


Domain annotation for each model (and alignments):
>> SPATA24  Spermatogenesis-associated protein 24
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.4   1.3e-05      0.11     110     177 ..      51     119 ..      38     123 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.3e-05
     SPATA24 110 kadqLkekCseveseierqeDilnakeneikeLkqrlskqkev...hraqlsdleiqkqq.evYmakvleds 177
                  + +L+ekC+ ++++    + +l + ++ i++Lk+r+++ + +   ++   + ++i  q  e Y    +e+s
  EFC37129.1  51 LCKYLLEKCDLINQQ---FDGCLKTYNVWIEDLKKRIKNDRVIgtnYHIDKKSVHISPQEdESYYEAEIEES 119
                 5889*****999865...578*******************98765566666777777554145655555555 PP

>> GABP-alpha  GA-binding protein alpha chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.012     1e+02      26      54 ..      15      42 ..       2      52 .. 0.77
   2 ?    8.1   0.1   0.00034       3.1       7      40 ..      49      82 ..      46     104 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.012
  GABP-alpha 26 vdlekyefyLQdaqkLdedksLvdqcvkg 54
                + l++   +LQ  +  +++k +v+ cvk 
  EFC37129.1 15 SLLSEMLSFLQFET-GEPSKQIVNFCVKC 42
                55677777888666.89**********96 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00034
  GABP-alpha  7 idikeplktLrklleerlqvdlekyefyLQdaqk 40
                i++ + l + ++l++++++  l++y++++ d +k
  EFC37129.1 49 IELCKYLLEKCDLINQQFDGCLKTYNVWIEDLKK 82
                67777788889********************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (138 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.31s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 864.06
//
Query:       EFC37130.1  [L=895]
Description: coatomer protein gamma 2-subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.4e-95  318.9  12.7    8.6e-95  318.3  12.7    1.3  1  Adaptin_N        Adaptin N terminal region
    4.2e-38  130.8   4.8    1.2e-37  129.3   4.8    1.9  1  COP-gamma_platf  Coatomer gamma subunit appendage platform su
    4.1e-22   78.5   0.3    1.3e-21   76.9   0.0    2.1  2  Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendag
    6.3e-15   55.3   0.1    0.00011   22.5   0.0    4.9  4  HEAT_2           HEAT repeats
    6.3e-12   45.8  12.0    0.00039   20.5   0.2    4.3  4  Cnd1             non-SMC mitotic condensation complex subunit
     0.0025   17.9   0.0     0.0067   16.5   0.0    1.8  1  B2-adapt-app_C   Beta2-adaptin appendage, C-terminal sub-doma
  ------ inclusion threshold ------
      0.012   15.8   1.1         58    4.3   0.1    5.2  5  HEAT             HEAT repeat
      0.035   14.4   0.1         12    6.3   0.1    3.1  2  TAF6_C           TAF6 C-terminal HEAT repeat domain
       0.13   12.8   2.2         18    6.0   0.3    4.4  5  HEAT_EZ          HEAT-like repeat


Domain annotation for each model (and alignments):
>> Adaptin_N  Adaptin N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  318.3  12.7   4.3e-98   8.6e-95       5     523 ..      30     545 ..      26     546 .. 0.94

  Alignments for each domain:
  == domain 1  score: 318.3 bits;  conditional E-value: 4.3e-98
                 CCHHHHHHCCSSS-SCHHHHHHHHHHHHHHHCT---G.....HHHHHHHCCCCSS-CHHHHHHHHHHHHHCTTSCCHHCCCCHHHHHHCC.SSSHHHHH CS
   Adaptin_N   5 iqqelaeilnsnkdddekkkeavkkliylialGedvs.....flffevvklvaskdfelKrlvYlylellaeesedlalLvtnslqkDlk.dpnqlirg 97 
                 + qe  +i+n+++ +++k+  ++  l+y+i++G+++      ++f++++kl+ s d+ l+r++Y+++++l+ ++ + + ++ nsl kD++ ++n+ ++ 
  EFC37130.1  30 VLQE-TRIFNESPLSPRKCVLTLLQLLYVIYQGKNLNateatDVFMNITKLFLSPDVRLRRMLYIAVKELSRTANQ-TFVASNSLFKDMSqNQNEDFKI 126
                 5566.79999999*********************77777788*********************************9.8888888888865499****** PP

                 HHHHHHCCC--CCCHHHHHHHHHHHHT-SSHHHHHHHHHHHHHCCCC..CHHCCCCCHHHHHHHCTT-SSHHHHHHHHHHHHHHHCCCCCCC.HHHHHH CS
   Adaptin_N  98 lALrvLssirvpelaedlapaikkllkdrspyvrkkAalailklykk..dpdllrkqlveeikellsdkdpgvvlaAvalleeikkndrlll.kllpkl 193
                 +A+r+L +i +++l   l++ +k++++d++p v ++A+la +++ ++    +l+++ ++ ei+++++++ ++v+++A+al ++++++d l++ k+++  
  EFC37130.1 127 NAIRSLRTIMDENLFSNLERHLKQCVVDKNPGVASSAILAGFHMSDSqkGDQLVKR-WTGEIQSAVDSRFHMVQYHALALSYKLRHQDGLAIsKIVSAG 224
                 ********************************************987324455555.7**************************999999556666666 PP

                 HCCHHHHHHCS-HHHHHHHHHHHCC---SSHHHH....HHHHHHHCGGCGCSSCHHHHHHHHHCCHCCCCSTHHHCCHHCHHHHHHSSCCTCHHHHHCH CS
   Adaptin_N 194 vrrLcnllteldpwlqvkiiklltrlarqepeersk..kellesllnllqssnnaVlletvnlivelapknelivlavnaLvrllsskdenlryvaLrt 290
                 +++L+      +p++++ +ik+  r +r e   +s   k +l+ l+++l+ +n++V+le++++i ++ +  + +++a++aL  +lss+++  r++a+r 
  EFC37130.1 225 MQNLR------SPLAHTLLIKYSMRIMRMEGNINSDrsKAILQYLTSCLKFRNDMVILEAAKAICTIRDLGKELSAAIEALRMFLSSNKPVKRFAAIRL 317
                 66555......*************999998887766779******************************9999*****************9******** PP

                 HHHHHHHXXTTTTTTTCCCCSXXTTSXHHHHHHHHHHHCCCXXTTTHHHHHHHHHHHTTSSXXHHHHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHTTX CS
   Adaptin_N 291 llkivkkepkavqhldlkifllktdddvsirlkaldlllklvdesNvkeivkeLkkyvkevadedfksklvkaIgrlaekfatdaewvldvllellsls 389
                 l+ ++ + p+ v++++ +++ l++d++++i+++a+++llk+++e+N+++++k+++ ++ e++de fk+ +vk+I +l++++++++ +++++l + l+++
  EFC37130.1 318 LNDVANHYPTLVSQCNNELEKLIADPNRNIATLAVTTLLKTGQETNIEKLMKKIQRFIPEIPDE-FKIIVVKSIESLCIRYPKKFYSMVSFLSNALRTE 415
                 *************************************************************999.********************************99 PP

                 XHHH.HHHHHHHHHHHHHHSTTTSTTCHHHHCCTCCGXXSHHHHHHHHHHHHHTTTTXTT...HHHHHHCTTTTTTTSXHHHHHHHHHHHHHHHHCXGC CS
   Adaptin_N 390 gesv.kdeivevirdliqkvpelheeiiekLaellekieseearaaaiWllGeygelvsntesasdllrslaekfvlesekvklqiltalvKlyltspd 487
                 g++  k++ v+ ++ + +  pe+++ i++ L+e++e++e++ +++++++ lG +g++ +    +s+ +r ++++++le+ +v+ +++ +++K+ +  pd
  EFC37130.1 416 GGYEyKKQLVSTLISICKALPESRDLIVSYLCEFIEDCEYTIVLQQVLHFLGDEGTQSTG---PSKCIRFIYNRLILENPTVRGSAVITIAKFAAKIPD 511
                 98766*******************************************************...**********************************95 PP

                 C.THXHHHHHHHHHHHXXSHHHHHHHHHHHHHHCCX CS
   Adaptin_N 488 ketqekliqlvlslatssdlevrdRaveylqllssa 523
                    +++++ ++++ + +sd+evrdRav+y + l+++
  EFC37130.1 512 --LRKSILVILRRVLLDSDDEVRDRAVFYVKALETK 545
                 ..778***********99************999876 PP

>> COP-gamma_platf  Coatomer gamma subunit appendage platform subdomain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  129.3   4.8   6.2e-41   1.2e-37       1     151 [.     632     780 ..     632     781 .. 0.93

  Alignments for each domain:
  == domain 1  score: 129.3 bits;  conditional E-value: 6.2e-41
  COP-gamma_platf   1 eeyaeqlaaipefaelGkllksskpveLTesetEYvVsvvKhifkehiVlqfnikNtledqvLenvsvqlepeeeelfeevfiipiek.Lkyne 93 
                      +ey++++++ip++++lGk++k+++p+ LTe +++YvVs+  h+f+++iVlq+ +kN +e+q+L+n  v+l+  + e ++evf i++e+ +k+n+
       EFC37130.1 632 QEYEQAITKIPQLQNLGKVFKTNPPIYLTEVDADYVVSCAIHVFESNIVLQYIVKNRVESQQLSNLIVDLDLGDFEDVQEVFKIQAESaIKFNQ 725
                      689********************************************************************9666677777888776439**** PP

  COP-gamma_platf  94 pgsvyvvlkrpseeeeklvsatfsntLkFtvkevdpstgepeeed.gyeDeYqledlel 151
                       +s++vvlkr    e++++++++  tLkF++ +vdp+tg+p +e+ + eDe++le +++
       EFC37130.1 726 AESTFVVLKR----EKEIATGKIFSTLKFCTADVDPETGDPYDEEdENEDEFELEAFNI 780
                      *********4....45689999********************9999**********998 PP

>> Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendage platform
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       5.5   1.1e+04      24      50 ..     621     647 ..     617     653 .. 0.57
   2 !   76.9   0.0   6.5e-25   1.3e-21       1     112 [.     783     890 ..     783     893 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 5.5
                      -EEEEEEESS---HHHHHHHHHHHHT- CS
  Coatomer_g_Cpla  24 eavetfaLssvksleeavdkliellgm 50 
                       ++et + +  ++ e+a++k+ +l ++
       EFC37130.1 621 TTTETSNANDTQEYEQAITKIPQLQNL 647
                      455555555666666666666555444 PP

  == domain 2  score: 76.9 bits;  conditional E-value: 6.5e-25
                      GGGEEE---S-HHHHHHHH-STT-EEEEEEE.SS---HHHHHHHHHHHHT-EE-TTTT---SS-SEEEEEEEEEETTS-EEEEEEEEEE..SS. CS
  Coatomer_g_Cpla   1 sDyikpvavsnFeaaWeeleseaeavetfaL.ssvksleeavdkliellgmqplegsdkvpenassHtLklaGkfvggekvlvrarlalssskg 93 
                      +D+++++avs+F+++W++l++e+e +++    ++ ++l++avdk+i+++g++p++  + v+  +++H+L++aGk++ g++vlv a+l+ ++ ++
       EFC37130.1 783 TDFVRNMAVSSFKEEWDKLGEESEFAQQPIEyTASDDLQAAVDKFISSVGLRPIGDRT-VS--KKTHSLYFAGKSIFGDMVLVAAQLGEKN-GS 872
                      59********************7777665555***********************999.54..568***********************88.99 PP

                      EEEEEEEEESSHHHHHHHH CS
  Coatomer_g_Cpla  94 vtlkltvRsedeevaelvl 112
                      ++lkl+vRs+  +++e ++
       EFC37130.1 873 ILLKLSVRSQG-DLRESIV 890
                      *********97.5666555 PP

>> HEAT_2  HEAT repeats
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0   0.00065       1.3       3      73 ..     111     185 ..      78     194 .. 0.74
   2 !    9.5   0.1   0.00064       1.3      29      87 ..     256     318 ..     243     319 .. 0.76
   3 !   13.1   0.0   4.8e-05     0.095       3      69 ..     298     369 ..     296     373 .. 0.85
   4 !   22.5   0.0   5.8e-08   0.00011       2      84 ..     444     536 ..     443     543 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00065
      HEAT_2   3 aLlqalendpdpevrraairaLgrignp....ealpaLvellededpavRraaaeaLgaigdpealpaLkelldd 73 
                  L + +++  +++ +++air+L +i ++     + + L +++ d++p v   a+ a   + d++  + L ++++ 
  EFC37130.1 111 SLFKDMSQNQNEDFKINAIRSLRTIMDEnlfsNLERHLKQCVVDKNPGVASSAILAGFHMSDSQKGDQLVKRWTG 185
                 455666677788888888888888877733334466666666788888888888887667777777777766665 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00064
      HEAT_2  29 npealpaLvellededpavRraaaeaLgaigd.....pealpaLkellddddddvvReaAaeaL 87 
                 ++ +l++L+++l+  + +v  +aa+a+  i+d     ++a++aL++ l   +++v R aA++ L
  EFC37130.1 256 SKAILQYLTSCLKFRNDMVILEAAKAICTIRDlgkelSAAIEALRMFLS-SNKPVKRFAAIRLL 318
                 5577999999999999999999999998775333345899999999775.57777788887655 PP

  == domain 3  score: 13.1 bits;  conditional E-value: 4.8e-05
      HEAT_2   3 aLlqalendpdpevrraairaLgrignp......ealpaLvellededpavRraaaeaLgaigdpealpaLke 69 
                 aL  +l ++  p  r aair L + +n       ++ + L +l+ d+++++   a+++L + g + +++ L +
  EFC37130.1 298 ALRMFL-SSNKPVKRFAAIRLLNDVANHyptlvsQCNNELEKLIADPNRNIATLAVTTLLKTGQETNIEKLMK 369
                 566667.666777788*******9888666788888*******************************999976 PP

  == domain 4  score: 22.5 bits;  conditional E-value: 5.8e-08
      HEAT_2   2 daLlqalendpdpevrraairaLg.....rignpealpaLvellededpavRraaaeaLgaig......dpealpaLkellddddddvvReaAa 84 
                 ++L++++e+++ + v +++++ Lg     + g+ ++++ + + l  e+p vR  a+ ++++++      +++ l +L++ l+ d+dd+vR +A+
  EFC37130.1 444 SYLCEFIEDCEYTIVLQQVLHFLGdegtqSTGPSKCIRFIYNRLILENPTVRGSAVITIAKFAakipdlRKSILVILRRVLL-DSDDEVRDRAV 536
                 689****99***************888766778899***********************99964454433556777777776.56777788875 PP

>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       4.3   8.7e+03      34      62 ..      84     115 ..      63     122 .. 0.45
   2 !   19.7   0.1   3.4e-07   0.00067       3     128 ..     125     268 ..     124     284 .. 0.80
   3 !   11.4   0.6   0.00012      0.24      20     100 ..     293     371 ..     277     466 .. 0.80
   4 !   20.5   0.2     2e-07   0.00039      24     103 ..     481     564 ..     477     589 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4.3
        Cnd1  34 dpyVRktaaivvakL...ilndmvkekgflse 62 
                 d   R+   i+v +L    ++++v ++ ++++
  EFC37130.1  84 DVRLRRMLYIAVKELsrtANQTFVASNSLFKD 115
                 33333333444444443333333333333333 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 3.4e-07
        Cnd1   3 RalairtlgcirvpnlveylvepLrkrLkDedpyVRktaaivvakL..ilndmvkekgflselaklleDenprVvanalaalteiseksenaiynllpd 99 
                 + +air+l +i  +nl  +l  +L++++ D++p V   a+++  ++   +++   +k    e++++++   ++V+  ala+  ++ ++++ ai ++++ 
  EFC37130.1 125 KINAIRSLRTIMDENLFSNLERHLKQCVVDKNPGVASSAILAGFHMsdSQKGDQLVKRWTGEIQSAVDSRFHMVQYHALALSYKLRHQDGLAISKIVSA 223
                 679*******************************************77666677899999*****************************9********* PP

        Cnd1 100 iisklsdalne................csewgqitilefLlsyip 128
                  +++l + l +                ++ +  + il++L+s+ +
  EFC37130.1 224 GMQNLRSPLAHtllikysmrimrmegnINSDRSKAILQYLTSCLK 268
                 ****99844333333333333444444666777777776666544 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 0.00012
        Cnd1  20 eylvepLrkrLkDedpyVRktaaivvakLilndmvkekgflselaklleDenprVvanalaalteiseksenaiynllpdi 100
                  + +e Lr  L+ ++p  R  a+ ++  + ++    +++  +el+kl+ D+n+++ ++a++ l +  +++  +i +l+++i
  EFC37130.1 293 SAAIEALRMFLSSNKPVKRFAAIRLLNDVANHYPTLVSQCNNELEKLIADPNRNIATLAVTTLLKTGQET--NIEKLMKKI 371
                 5667788888888888777777778888899999999999********************9998887775..344444433 PP

  == domain 4  score: 20.5 bits;  conditional E-value: 2e-07
        Cnd1  24 epLrkrLkDedpyVRktaaivvakLilndmvkekgflselaklleDenprVvanalaalteisekse....naiynllpdiisk 103
                   +++rL  e+p+VR  a+i++ak   +     k +l  l++ l D++++V++ a++  + + +k+e    ++i+n lpd +++
  EFC37130.1 481 RFIYNRLILENPTVRGSAVITIAKFAAKIPDLRKSILVILRRVLLDSDDEVRDRAVFYVKALETKDEdlirKLIVNDLPDNMQH 564
                 6688888889***************99999999999*****************************8734444455555555544 PP

>> B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   3.4e-06    0.0067       6     103 ..     789     892 ..     787     895 .] 0.83

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3.4e-06
  B2-adapt-app_C   6 ldreeFlekWkslpesneqsltlsnnvas.tspdaleekLqanniftiAkrgvegqqeklYfsakltngilfLvellintsg.k.svkvsvKse. 96 
                     +  ++F+e W  l e+ e+  +  + +as + + a+ + ++++++  i+ r+v +++  lYf++k   g ++Lv   + +++ +  +k+sv+s+ 
      EFC37130.1 789 MAVSSFKEEWDKLGEESEFAQQPIEYTASdDLQAAVDKFISSVGLRPIGDRTVSKKTHSLYFAGKSIFGDMVLVAAQLGEKNgSiLLKLSVRSQg 883
                     77789*********88887665554346757777788888999*********************************9999998999******987 PP

  B2-adapt-app_C  97 ..dpevapl 103
                       +++++++
      EFC37130.1 884 dlRESIVQQ 892
                     665666555 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       8.1   1.6e+04       8      28 ..     116     136 ..     112     137 .. 0.75
   2 ?   -3.0   0.0       6.8   1.4e+04       6      23 ..     149     166 ..     147     166 .. 0.77
   3 ?    2.7   0.0     0.096   1.9e+02       8      30 ..     301     324 ..     296     325 .. 0.81
   4 ?    2.4   0.0      0.12   2.5e+02      12      29 ..     490     507 ..     490     509 .. 0.89
   5 ?    4.3   0.1     0.029        58       5      26 ..     520     541 ..     516     542 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 8.1
                 HHT-SSHHHHHHHHHHHHHHH CS
        HEAT   8 llsDpspeVReaAakaLgala 28 
                 + + ++ +   +A+++L +++
  EFC37130.1 116 MSQNQNEDFKINAIRSLRTIM 136
                 556677777889999999986 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 6.8
                 HHHHT-SSHHHHHHHHHH CS
        HEAT   6 lkllsDpspeVReaAaka 23 
                  ++  D++p V ++A++a
  EFC37130.1 149 KQCVVDKNPGVASSAILA 166
                 566689***999999875 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.096
                 H.HT-SSHHHHHHHHHHHHHHHHC CS
        HEAT   8 l.lsDpspeVReaAakaLgalaev 30 
                 + ls++ p  R aA++ L ++a +
  EFC37130.1 301 MfLSSNKPVKRFAAIRLLNDVANH 324
                 5368889999********999876 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.12
                 SSHHHHHHHHHHHHHHHH CS
        HEAT  12 pspeVReaAakaLgalae 29 
                 ++p VR +A+ +++++a 
  EFC37130.1 490 ENPTVRGSAVITIAKFAA 507
                 69************9986 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.029
                 HHHHHT-SSHHHHHHHHHHHHH CS
        HEAT   5 llkllsDpspeVReaAakaLga 26 
                 l + l D++ eVR+ A+  + a
  EFC37130.1 520 LRRVLLDSDDEVRDRAVFYVKA 541
                 555589**********987765 PP

>> TAF6_C  TAF6 C-terminal HEAT repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.1    0.0061        12      33      80 ..     317     362 ..     280     372 .. 0.86
   2 ?    4.7   0.0     0.019        38      34      88 ..     502     557 ..     498     559 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0061
      TAF6_C  33 ilkkysssyktLkprvtrtllkvlldpkkslgtlyGallglaalGeea 80 
                 +l+  ++ y+tL ++  + l k + dp+++++tl  a+++l + G+e+
  EFC37130.1 317 LLNDVANHYPTLVSQCNNELEKLIADPNRNIATL--AVTTLLKTGQET 362
                 5677788899***********************9..899999998765 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.019
      TAF6_C  34 lkkysssyktLkprvtrtllkvlldpkkslgt.lyGallglaalGeeavrklvlpn 88 
                 + k++ + + L++ ++ +l +vlld+++++   +   + +l   +e+ +rkl++  
  EFC37130.1 502 IAKFAAKIPDLRKSILVILRRVLLDSDDEVRDrAVFYVKALETKDEDLIRKLIVND 557
                 57999********************9766554266678888888888888888765 PP

>> HEAT_EZ  HEAT-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.5   3.1e+03      27      48 ..     257     279 ..     250     286 .. 0.86
   2 ?    1.1   0.0       0.3   5.9e+02      19      49 ..     285     315 ..     277     321 .. 0.73
   3 ?    0.0   0.0      0.66   1.3e+03       4      52 ..     311     355 ..     308     355 .. 0.66
   4 ?    1.6   0.0      0.21   4.2e+02      40      54 ..     490     504 ..     480     505 .. 0.87
   5 ?    6.0   0.3     0.009        18       3      49 ..     494     536 ..     492     537 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.5
     HEAT_EZ  27 peilpaLlalLnddsdeV.RaaA 48 
                 ++il +L ++L+  +d+V  +aA
  EFC37130.1 257 KAILQYLTSCLKFRNDMViLEAA 279
                 579999**********9987665 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.3
     HEAT_EZ  19 pellqplvpeilpaLlalLnddsdeV.RaaAa 49 
                  ++l +++++++ aL  +L +++++V R aA+
  EFC37130.1 285 IRDLGKELSAAIEALRMFL-SSNKPVkRFAAI 315
                 578999999*******666.468899555555 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.66
     HEAT_EZ   4 RraAawaLGr.laggepellqplvpeilpaLlalLnddsdeVRaaAagaL 52 
                 R+aA++ L + +a++ p l    v++   +L +l  d++ ++ + A+ +L
  EFC37130.1 311 RFAAIRLL-NdVANHYPTL----VSQCNNELEKLIADPNRNIATLAVTTL 355
                 88999999.5566555554....446666777777777777777777665 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.21
     HEAT_EZ  40 dsdeVRaaAagaLgn 54 
                 ++++VR+ A++++++
  EFC37130.1 490 ENPTVRGSAVITIAK 504
                 799*********986 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.009
     HEAT_EZ   3 vRraAawaLGrlaggepellqplvpeilpaLlalLnddsdeVRaaAa 49 
                 vR +A+ +++  a+     +++l + il  L + L d++deVR  A+
  EFC37130.1 494 VRGSAVITIAKFAA----KIPDLRKSILVILRRVLLDSDDEVRDRAV 536
                 66677777765443....4555556999999999*********9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (895 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       724  (0.0403815); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.80u 0.33s 00:00:01.13 Elapsed: 00:00:00.50
# Mc/sec: 5347.36
//
Query:       EFC37131.1  [L=660]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.6e-32  111.8   2.0    9.1e-29  100.7   0.4    3.6  4  eIF2A     Eukaryotic translation initiation factor eIF2A
    0.00021   21.0   0.2    0.00065   19.5   0.2    1.9  1  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom
  ------ inclusion threshold ------
      0.028   14.4   1.9      0.037   14.0   1.0    1.7  2  TF_AP-2   Transcription factor AP-2
      0.092   13.7   1.0         48    5.0   0.1    4.0  4  WD40      WD domain, G-beta repeat
       0.11   12.5  10.4       0.38   10.8   5.9    2.5  2  YqeY      Yqey-like protein


Domain annotation for each model (and alignments):
>> eIF2A  Eukaryotic translation initiation factor eIF2A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0     0.098   3.5e+02     128     161 ..     171     207 ..     132     215 .. 0.82
   2 !    7.0   0.0    0.0014         5     106     167 ..     195     252 ..     181     256 .. 0.77
   3 !    6.0   0.0    0.0027       9.8      61     138 ..     230     308 ..     218     351 .. 0.56
   4 !  100.7   0.4   2.5e-32   9.1e-29       2     193 ..     362     558 ..     361     559 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.098
                 EE.EETT.TTEEEEEEE-TT-.-EEEE-TTSSEEEEE CS
       eIF2A 128 ei.wdvk.kkkkiakaeaana.tlvewspdgryvlTa 161
                 +i w+   ++k+i   ++ ++  ++++sp g+y++T 
  EFC37131.1 171 DIcWNDPlHVKEIIYSKERWSdDKIDFSPLGSYIVTY 207
                 5556655566666666666652579**********95 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0014
                 EEE-TTSSEEEEE-TTSSS-EEEEEETTTTEEEEEEE-TT--EEEE-TTSSEEEEEE-TTT- CS
       eIF2A 106 iffspkgklvllaGfgnlaGeleiwdvkkkkkiakaeaanatlvewspdgryvlTattaprl 167
                 i fsp g ++++   +     +++w   ++k   ++ + n  +v++sp+ ++v+T + +p  
  EFC37131.1 195 IDFSPLGSYIVTYHEK----GVALWGGPEFKDQDTLSHRNVISVQFSPNESFVVTVSESPAR 252
                 5566666666654333....35788888999999***********************99965 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0027
                 .EEEEEE-TTSS-EEEEESSSSCEEEEEECS.CEEEEEEEEES--EE.....EE-TTSSEEEEE-TTSSS-EEEEEETTTTEEE CS
       eIF2A  61 pihdvaWspkskefaviyGkmpakvslfdlk.vkviskleeqkrNti.....ffspkgklvllaGfgnlaGeleiwdvkkkkki 138
                 +++ v+ sp++  f+v   ++pa+++l+dl+  ++ ++l  + r ++     ++s+ +k+++  G   +     i+d ++++ +
  EFC37131.1 230 NVISVQFSPNE-SFVVTVSESPARAVLWDLRaQRKAMSLPLKDRSALkghvfKWSADEKYFAKMGVDCI----HIFDSSTMELL 308
                 35666666654.466666677777777777633333444444443331111156666666666665443....66666655555 PP

  == domain 4  score: 100.7 bits;  conditional E-value: 2.5e-32
                 EESSECEEEEEE-TTTTEEEEEEE.E--.TT-CEEEEEEEEEESSSTT--EEECCEESSS.EEEEEE-TTSS-EEEEES..SSSCEEEEEECS...CEE CS
       eIF2A   2 sffkadkvklkWnkkGtsllvlvstevd.ktnksyygetelyliklkkkksevvelkkegpihdvaWspkskefaviyG..kmpakvslfdlk...vkv 94 
                   ++++++kl W+ +G+++++ +s e++ + +k  ++++++  ++ k+ ++e +   ++  +  ++ +p ++ +a+i+G  ++ ++ sl++ k    k+
  EFC37131.1 362 PYYNSTDIKLNWQLSGDYIAIATSRESTiQMEKVITTAFDVMKVNQKNFPIEGIADFND-CVDEFEFEPIGDTLAIIHGpgNVKKSFSLYSFKnavHKL 459
                 57899*******************77662667888999999999999999999965555.6*****************9556667999***98787899 PP

                 EEEEEEES--EEEE-TTSSEEEEE-TTSSS-EEEEEETTTTEEEEEEE-TT--EEEE-TTSSEEEEEE-TTT-SSS-EEEEEETTTEEEEEEE-TTEEE CS
       eIF2A  95 iskleeqkrNtiffspkgklvllaGfgnlaGeleiwdvkkkkkiakaeaanatlvewspdgryvlTattaprlrvdngfkiwsysGklvykkefdelyq 193
                 i+k e +  N +++sp+g+ ++l + + ++ +le+w+ ++ + + + e++  t+  w+p+gry+ T+++a r   dngf iw++ Gk+++k ++++l++
  EFC37131.1 460 IKKCEGKTINRMLWSPRGHDLVLMNTKLVSVTLEFWNAEEGELVGTGEHFSMTDACWDPSGRYFSTFVSAERRSNDNGFIIWTFLGKVMHKANVERLLE 558
                 999**********************************************************************************************87 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.2   1.8e-07   0.00065      23      70 .]      68     114 ..      50     114 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.8e-07
                 SCEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEEE CS
       RRM_1  23 GpiksiklvrdetgkskgfafVeFeskedAekAlealngkklggrelk 70 
                  +i+++ +++ + gkskg+a+Ve  + e+A+k l+   g k+ + +l+
  EFC37131.1  68 AKIVNFYIPY-QAGKSKGMAIVELSTAEQAKKVLDGIEGFKFASFTLH 114
                 5788899999.7*****************************9998875 PP

>> TF_AP-2  Transcription factor AP-2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       3.2   1.1e+04      88     108 ..     396     416 ..     390     418 .. 0.68
   2 ?   14.0   1.0     1e-05     0.037      90     169 ..     569     653 ..     566     658 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 3.2
     TF_AP-2  88 vhlakDleklceeefpakaia 108
                 +  a D+ k+ +++fp++ ia
  EFC37131.1 396 ITTAFDVMKVNQKNFPIEGIA 416
                 455667777788888877776 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 1e-05
     TF_AP-2  90 lakDleklceeefpaka..iaeelvkealedenlelekrkekleaakqilkelkdllesdrpp...ltsrvpkkikeeklqssle 169
                 l +++ek +++ +p k+  i ++l++ea++ ++++l+krk++ ++++q+l++lk+ +e+ +p    l+++ p + ++e++++ +e
  EFC37131.1 569 LTANMEKEVKKRLPNKKveIEQKLLQEAKALREAKLKKRKSAWDEFEQVLARLKSQYEKMKPEliaLKGYDPDEFNQEEVDEVIE 653
                 67899*********99722578999**9997777**************************9985334566777777777776665 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       2.3   8.2e+03      16      29 ..     195     208 ..     194     215 .. 0.73
   2 ?    4.3   0.0     0.023        83       7      29 ..     226     247 ..     220     257 .. 0.79
   3 ?   -3.5   0.0         5   1.8e+04       7      23 ..     313     328 ..     309     331 .. 0.67
   4 ?    5.0   0.1     0.013        48       9      37 ..     507     541 ..     500     542 .. 0.63

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.3
                 EEEETTSSEEEEEE CS
        WD40  16 lafspdgawlasGs 29 
                 ++fsp g+++++ +
  EFC37131.1 195 IDFSPLGSYIVTYH 208
                 689*****999745 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.023
                 EESSSSEEEEEEETTSSEEEEEE CS
        WD40   7 ltGHssvtslafspdgawlasGs 29 
                 l  H +v s++fsp+ +++++ s
  EFC37131.1 226 L-SHRNVISVQFSPNESFVVTVS 247
                 4.373466**********99865 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 5
                 EESSSSEEEEEEETTSS CS
        WD40   7 ltGHssvtslafspdga 23 
                 ++   +v+++af+p g+
  EFC37131.1 313 YSVP-GVRDFAFNPVGK 328
                 4433.499999999765 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.013
                 SSSSEEEEEEETTSSEEEE...E...ETTSEEEEE CS
        WD40   9 GHssvtslafspdgawlas...G...sdDgtvriW 37 
                  H+s t+ +++p+g+++++   +   s D+   iW
  EFC37131.1 507 EHFSMTDACWDPSGRYFSTfvsAerrSNDNGFIIW 541
                 47789***********6432214333336666666 PP

>> YqeY  Yqey-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1     0.023        81      75     106 ..      63      94 ..      51     102 .. 0.84
   2 ?   10.8   5.9    0.0001      0.38      26     103 ..     577     655 ..     564     660 .] 0.76

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.023
                 HHHHHHHHHGGGS-----HHHHHHHHHHHHHH CS
        YqeY  75 kekaEievleeYlPeqlseeeiealvkeaiae 106
                 ++kaE+++++ Y+P q  +++  a+v+   ae
  EFC37131.1  63 EKKAEAKIVNFYIPYQAGKSKGMAIVELSTAE 94 
                 5789*************999999998877666 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.0001
                 HHHHHHHHHHHTTSS.--HHHHHHHHHHHHHHHHHHHHHHHH..HT-HHHHHHHHHHHHHHGGGS-----HHHHHHHHHHH CS
        YqeY  26 lkaaikqeevderke.lsdeevlkvlakevkqRresieefek..agRedlaekekaEievleeYlPeqlseeeiealvkea 103
                 +k  + +++v+ +++ l++++ l   + ++k+R+ + +efe+  a  +   ek k E+  l+ Y P++ ++ee++++++++
  EFC37131.1 577 VKKRLPNKKVEIEQKlLQEAKAL--REAKLKKRKSAWDEFEQvlARLKSQYEKMKPELIALKGYDPDEFNQEEVDEVIETI 655
                 55566666666666524444444..47889***********9544557889*************************99754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (660 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1592  (0.0887947); expected 358.6 (0.02)
Passed bias filter:                      635  (0.0354175); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.78u 0.33s 00:00:01.11 Elapsed: 00:00:00.50
# Mc/sec: 3961.59
//
Query:       EFC37132.1  [L=637]
Description: hypothetical protein NAEGRDRAFT_59821 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
        2.5    6.8   5.9        3.8    6.2   5.9    1.2  1  Androgen_recep  Androgen receptor


Domain annotation for each model (and alignments):
>> Androgen_recep  Androgen receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   5.9   0.00021       3.8     189     208 ..      24      43 ..       6      82 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.00021
  Androgen_recep 189 llqqqqqehhhqqhqhqqqq 208
                       qqqqq hhh++hqhqq +
      EFC37132.1  24 HQQQQQQPHHHHHHQHQQCD 43 
                     45888999999999999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (637 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1484  (0.0827709); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.25s 00:00:00.83 Elapsed: 00:00:00.43
# Mc/sec: 4410.42
//
Query:       EFC37133.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.029   13.6   0.1       0.03   13.6   0.1    1.1  1  ISG65-75        Invariant surface glycoprotein
      0.049   14.0   2.0       0.44   11.0   2.0    2.0  1  NuiA            Nuclease A inhibitor-like protein
       0.06   13.3   0.2      0.062   13.2   0.2    1.1  1  PDDEXK_6        PDDEXK-like family of unknown function
      0.098   13.0   0.0       0.23   11.8   0.0    1.7  1  SAP30_Sin3_bdg  Sin3 binding region of histone deacetylase co


Domain annotation for each model (and alignments):
>> ISG65-75  Invariant surface glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1   6.7e-06      0.03      47     124 ..       8      87 ..       1     104 [. 0.82

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 6.7e-06
    ISG65-75  47 vreetadyllketkdklayienakekvdyyvekleslleeake..kgtltesdaeklkkaceeAkaknkkarekakkale 124
                 +++++  ++ +++k+ +ay++ +++ +++y++++  ++ e++   +++++e+++++ ++++e  k  n++ +++ kk+++
  EFC37133.1   8 LSGQGIADDTNQVKNLVAYLKGKLATLKRYQDNFDLVVSEQNDdwQNKKEENNIDEFTELYETLKSSNSNYESNLKKEVN 87 
                 56666678999***********************8877776555677888888888899999999999999999988765 PP

>> NuiA  Nuclease A inhibitor-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   2.0   9.8e-05      0.44      40      95 ..      19      76 ..      14      80 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 9.8e-05
                HHHHHHT-TTTSSCEEE-HHHHTTCTT--..SSTS-HHHHHHHHHHHHHHHHHTTHSS CS
        NuiA 40 kllketghpadtpvesveldeflrnalte..eewyeeeekeeaqrfqtlvklLksnLt 95
                ++++++   +++  +    ++ +  ++ e   +w++++e++++  f +l+++Lks+ +
  EFC37133.1 19 QVKNLVAYLKGKLATLKRYQDNFDLVVSEqnDDWQNKKEENNIDEFTELYETLKSSNS 76
                555566666666666666666666666554589*********************9755 PP

>> PDDEXK_6  PDDEXK-like family of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   1.4e-05     0.062      28      94 ..      46     114 ..      20     118 .] 0.71

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.4e-05
    PDDEXK_6  28 feeeseedsdeekdsseeaaellkellesassaerklladvseavekakkevk..kkeeekrsclrrav 94 
                 +e++++ ++++e+++ +e +el ++l++s+s++e++l ++v+++++++  +    ++++++ +cl++ +
  EFC37133.1  46 SEQNDDWQNKKEENNIDEFTELYETLKSSNSNYESNLKKEVNTLLHSMYPSAFtpNSTTTQITCLKTGI 114
                 23334445556666888999999999*******************997655444555566677777655 PP

>> SAP30_Sin3_bdg  Sin3 binding region of histone deacetylase complex subunit SAP30
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   5.1e-05      0.23       3      20 ..      31      48 ..      30      58 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.1e-05
  SAP30_Sin3_bdg  3 lntLrrYkrhyklekvrp 20
                    l+tL+rY+ +++l+  ++
      EFC37133.1 31 LATLKRYQDNFDLVVSEQ 48
                    79***********43333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1818  (0.1014); expected 358.6 (0.02)
Passed bias filter:                      727  (0.0405488); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 786.58
//
Query:       EFC37134.1  [L=906]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   3.9e-100  335.5   8.5   3.9e-100  335.5   8.5    2.6  3  Vps53_N        Vps53-like, N-terminal
    2.9e-08   33.4   8.8    2.9e-08   33.4   8.8    2.4  3  Vps54_N        Vacuolar-sorting protein 54, of GARP complex
  ------ inclusion threshold ------
      0.016   15.4   2.3      0.016   15.4   2.3    2.9  3  COG5           Golgi transport complex subunit 5
        0.1   12.2   2.8        6.2    6.3   0.8    2.6  2  DUF2110        Uncharacterized protein conserved in archaea (
       0.25   11.7   9.4        1.3    9.3   1.1    4.1  3  V-SNARE_C      Snare region anchored in the vesicle membrane 
       0.71    9.7  15.0        1.6    8.6   2.3    4.5  4  DUF2570        Protein of unknown function (DUF2570)
        1.2    7.5   2.2       0.72    8.3   0.4    1.5  2  FUSC           Fusaric acid resistance protein family
        2.8    8.2   6.4         19    5.5   0.0    4.7  5  PAH            Paired amphipathic helix repeat
        3.4    7.6  18.3       0.63   10.0   0.3    4.5  5  DUF489         Protein of unknown function (DUF489)
        6.1    6.3   7.0          2    7.9   0.1    2.8  3  GTP_EFTU       Elongation factor Tu GTP binding domain
        6.9    7.1   7.0         40    4.7   1.7    4.5  3  Goodbye        fungal STAND N-terminal Goodbye domain
        9.6    6.3   9.2        1.1    9.4   0.4    3.9  5  DUF1539        Domain of Unknown Function (DUF1539)


Domain annotation for each model (and alignments):
>> Vps53_N  Vps53-like, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  335.5   8.5  2.6e-103  3.9e-100       4     379 ..      41     497 ..      38     498 .. 0.92
   2 ?   -4.1   0.0       3.9   5.8e+03     342     359 ..     528     545 ..     518     552 .. 0.65
   3 ?   -0.8   0.1      0.39   5.8e+02     165     194 ..     841     870 ..     816     905 .. 0.61

  Alignments for each domain:
  == domain 1  score: 335.5 bits;  conditional E-value: 2.6e-103
     Vps53_N   4 fsaleyinellpteqsla.nidelikklqeeikklddeiksvvraqanvgekgkealeeaqkaieelfqkikeikdkaekseemvkeitrdIkqLDiAK 101
                 f+++ yin  +p+eq+l+ ++++ i k++++i+++d++i  +vr+q+++g +++++leea ++i++lf+ki+eik+kae+se+mv++it+dIk LD+ K
  EFC37134.1  41 FDPVHYINLRFPNEQALNeGLESSIIKVKKKIQRVDEDILVAVRKQSSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNITKDIKSLDYGK 139
                 799**************846******************************************************************************* PP

     Vps53_N 102 knlttsiTtlkrLkmLvtavesleallskrsykeivsllqavlqllnhFekYk.dvekIaeLsesisklkkslksqiledfkeaFssgsqkeketgnll 199
                 +nlt ++TtlkrL+mLv+av++l   ++k++yk++++ll+av++ll  FekYk +++k+++L  + + +kksl  q+++dfk++     +k+    n  
  EFC37134.1 140 RNLTVTMTTLKRLHMLVSAVDKLTLYTQKKQYKQVAELLEAVNELLANFEKYKsSIPKVQNLFMRFESVKKSLRDQLFQDFKSLD---AHKNSGRENVQ 235
                 ****************************************************8459****************************3...44444444579 PP

     Vps53_N 200 ekledaCrvvdildpsvkeelikwfie.kqLeeykkifreneeaasLdkldrRYawlkrklqdfeekykkiFpadWevaeRltveFckvTrkdlekilk 297
                 + l++aC+ vd+l  s++ eli +f++ + L+ y   fre++e ++L+++ +RY+wl + l+ ++e++++iFp  W v++ +tveF  +Tr+ + ++l 
  EFC37134.1 236 QLLSEACLAVDALGDSIRTELISQFVKnRALHVYDMTFREGKEESKLERIADRYKWLMKVLKSYQEQFGDIFPSFWSVPQEITVEFSLMTRQAIVQML- 333
                 9*************************7368********************************************************************. PP

     Vps53_N 298 rkkkelsvkllllalqsTleFEklldkrF...................................................................... 326
                 ++ +++s k l + + sT +FE+ +++rF                                                                      
  EFC37134.1 334 QRGNNVSGKTLYTVILSTIKFERDMQERFydpdeseilvdlqqqkrqldqeekllkeagqklqegspeandnlkkqfkimikrrelekvenditktstl 432
                 899*******************************99999999999998888888888888888888888888888888888877777777777777777 PP

     Vps53_N 327 .............sntiskakkkkekkelafegaisscFephltlyiesqektlsellekfvseek 379
                               +++ kakkk+++k  +f g isscFe h+ +yie +e  + e+l +++++e 
  EFC37134.1 433 dsllkegdgsasgIKEVEKAKKKPKNK-YNFIGFISSCFEEHMSVYIEYEEESMRETLSNIIQKET 497
                 777777777766655555566655555.66********************************9986 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 3.9
     Vps53_N 342 lafegaisscFephltly 359
                  + ++ + ++F+ +l  y
  EFC37134.1 528 KTLYDLVEKVFKKYLAEY 545
                 345666667777766655 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.39
     Vps53_N 165 sisklkkslksqiledfkeaFssgsqkeke 194
                 ++++l+k+ k+qile +++  +  + ++ +
  EFC37134.1 841 ELKELQKNEKQQILEGYQKELRKRQGGDAK 870
                 367788888888888888776633333333 PP

>> Vps54_N  Vacuolar-sorting protein 54, of GARP complex
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.4   8.8   1.9e-11   2.9e-08      12     184 ..      40     216 ..      34     241 .. 0.87
   2 ?   -3.4   0.3       3.1   4.6e+03      40      85 ..     478     523 ..     466     530 .. 0.72
   3 ?   -3.3   0.3       2.8   4.2e+03      17      68 ..     638     687 ..     626     691 .. 0.46

  Alignments for each domain:
  == domain 1  score: 33.4 bits;  conditional E-value: 1.9e-11
     Vps54_N  12 efdpikyeLkklpddelsyesiekevkklksqhdvvskklsqlilekreefvkelseveeiekelkesvvickngrraLdlakkeltrtsLellakskk 110
                  fdp++y+  + p++++ +e +e+++ k+k++ + v++ ++  +++++++ v+    +ee ++ +++  +++++++++ +++++ + +    + +  + 
  EFC37134.1  40 FFDPVHYINLRFPNEQALNEGLESSIIKVKKKIQRVDEDILVAVRKQSSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNITKDIKSLDYG 138
                 69**************999***************************************************************99999999999998887 PP

     Vps54_N 111 rqllkkllktltaikelrelekrleelleeedysaAiqllletkqlaekysqync....vqelssklqetlelveekl 184
                 +  l+  ++tl+ +  l ++  +l    ++++y +  +ll  +++l+ ++++y++    vq+l    + + +++ ++l
  EFC37134.1 139 KRNLTVTMTTLKRLHMLVSAVDKLTLYTQKKQYKQVAELLEAVNELLANFEKYKSsipkVQNLFMRFESVKKSLRDQL 216
                 777888889********************************************8643334444444444444444444 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 3.1
     Vps54_N  40 lksqhdvvskklsqlilekreefvkelseveeiekelkesvvickn 85 
                 ++ + + + ++ls+ i ++   +++e s  +++   + es++ c++
  EFC37134.1 478 IEYEEESMRETLSNIIQKETWDMNSEYSSSQDLFMYIVESMKSCSA 523
                 4445567788888888888888888888888888888888888865 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 2.8
     Vps54_N  17 kyeLkklpddelsyesiekevkklksqhdvvskklsqlilekreefvkelse 68 
                 + eLk+  ++   +++++ + ++ + +h v+++ +  l+ +  + + k++se
  EFC37134.1 638 QDELKETLQE-PYCDQVDLSEEQGQFYH-VLKSGIEVLVHNLMNVMEKQFSE 687
                 4444444444.33334444444444444.44455555555555555555544 PP

>> COG5  Golgi transport complex subunit 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   2.3   1.1e-05     0.016       3     132 .]      36     162 ..      34     162 .. 0.93
   2 ?   -2.6   0.1       3.7   5.6e+03      59      86 ..     183     210 ..     168     249 .. 0.54
   3 ?   -3.3   0.3       6.3   9.5e+03      57      78 ..     384     407 ..     371     437 .. 0.48

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 1.1e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-TTHHHHHH CS
        COG5   3 FLepdFdpksfanallkatnnnddteldlstplkrlnydiqeldkrlrqlitsnhleLlehlskskslssvlselksslesLsasyerlkskvlepyee 101
                 F ++ Fdp+++ n       n++  ++ l++++ +++  iq +d+ +   ++++ ++  +  ++ ++++++ ++l ++++++++  e+ ++ v +  ++
  EFC37134.1  36 FDSSFFDPVHYINLRFP---NEQALNEGLESSIIKVKKKIQRVDEDILVAVRKQSSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNITKD 131
                 66777999999998777...788888999********************************************************************** PP

                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        COG5 102 aeklqsalkrlhqtldLlrralrflhlskqL 132
                 +++l     +l  t+++l+r+++++  + +L
  EFC37134.1 132 IKSLDYGKRNLTVTMTTLKRLHMLVSAVDKL 162
                 ***********************99877765 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 3.7
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        COG5  59 eLlehlskskslssvlselksslesLsa 86 
                 eLl++++k ks    +++l  + es+++
  EFC37134.1 183 ELLANFEKYKSSIPKVQNLFMRFESVKK 210
                 3444444443333333333333333333 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 6.3
                 XXXXXXXXXXXXXXXX..XXXXXX CS
        COG5  57 hleLlehlskskslss..vlselk 78 
                 +++Ll+++ +++++ s   +++lk
  EFC37134.1 384 EEKLLKEAGQKLQEGSpeANDNLK 407
                 344444443333322223333333 PP

>> DUF2110  Uncharacterized protein conserved in archaea (DUF2110)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.8    0.0042       6.2      12     123 ..      60     185 ..      52     226 .. 0.81
   2 ?    4.8   0.0     0.012        18      63     132 ..     451     520 ..     440     551 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0042
     DUF2110  12 alesleslvenelkdLdveleisvreddfvkvtleGedeevaanllreefgeitkeveegevyvGtlesldedgfvldigve.vripkdelkpLge... 106
                  les   +v+++++ +d ++ ++vr++    v+ +  d e a++ +++ f +i++  ++ e+   +++++++d   ld g++ ++++   lk L     
  EFC37134.1  60 GLESSIIKVKKKIQRVDEDILVAVRKQSSSGVQAR-RDLEEARETIQSLFKKINEIKSKAEQSEQMVQNITKDIKSLDYGKRnLTVTMTTLKRLHMlvs 157
                 5677778999999999*99*9*****999999987.79999**************9999999999********99*****9867888888888877666 PP

     DUF2110 107 ...........gspeqiaerFGlvqhlp 123
                            ++ +q+ae    v++l 
  EFC37134.1 158 avdkltlytqkKQYKQVAELLEAVNELL 185
                 7777777766656666666655555555 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.012
     DUF2110  63 eitkeveegevyvGtlesldedgfvldigvevripkdelkpLgegspeqiaerFGlvqhlpleveveeve 132
                 + +k+ +++  + G+++s  e+++ + i  e + + + l+++ ++++ ++ ++++  q+l + ++ + ++
  EFC37134.1 451 KAKKKPKNKYNFIGFISSCFEEHMSVYIEYEEESMRETLSNIIQKETWDMNSEYSSSQDLFMYIVESMKS 520
                 5566778888999***********************************************9999874433 PP

>> V-SNARE_C  Snare region anchored in the vesicle membrane C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   1.1   0.00089       1.3      21      63 ..      87     129 ..      82     130 .. 0.92
   2 ?    3.2   1.0     0.072   1.1e+02      26      52 ..     369     395 ..     368     398 .. 0.89
   3 ?    0.6   0.0      0.47     7e+02      34      57 ..     874     897 ..     872     898 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00089
   V-SNARE_C  21 isiGaailedLhsQretLkrarsklhnvanrlgksnsiLrsik 63 
                  s+G++ ++dL + ret+++  +k++++ ++   s + ++ i+
  EFC37134.1  87 SSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNIT 129
                 589****************************999999999986 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.072
   V-SNARE_C  26 ailedLhsQretLkrarsklhnvanrl 52 
                 +il dL++Q+ +L +  + l++++++l
  EFC37134.1 369 EILVDLQQQKRQLDQEEKLLKEAGQKL 395
                 89***********99999999999887 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.47
   V-SNARE_C  34 QretLkrarsklhnvanrlgksns 57 
                 Q + +++a++k+ ++++++ +s++
  EFC37134.1 874 QASAIGTATKKMEQATSAIMTSSK 897
                 88999************9988875 PP

>> DUF2570  Protein of unknown function (DUF2570)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   2.3    0.0011       1.6      41      86 ..      85     130 ..      63     154 .. 0.84
   2 ?   -2.8   0.1       3.7   5.5e+03      66      69 ..     394     397 ..     373     435 .. 0.46
   3 ?   -0.3   0.1      0.62   9.3e+02      24      89 ..     431     497 ..     425     501 .. 0.55
   4 ?    7.2   0.2     0.003       4.4      55      97 ..     615     657 ..     602     663 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0011
     DUF2570  41 eqqkanqrLteqLeqerqavekqqkianelkakveeekeevktilk 86 
                 +q     +   +Le  r  ++   k+ ne+k k+e++++ v++i k
  EFC37134.1  85 KQSSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNITK 130
                 5555556667889******************************976 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.7
     DUF2570  66 iane 69 
                 + +e
  EFC37134.1 394 KLQE 397
                 2222 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.62
     DUF2570  24 kidsLraenkaqaqlieeqqkanqrLteqLeqerqav.ekqqkianelkakveeekeevktilkqes 89 
                 ++dsL  e    a+ i+e +ka ++ +++ +          ++++  ++ + e  +e++ +i+++e+
  EFC37134.1 431 TLDSLLKEGDGSASGIKEVEKAKKKPKNKYNFIGFISsCFEEHMSVYIEYEEESMRETLSNIIQKET 497
                 5666666666666666666666665554444322222022233344455666777777888887775 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.003
     DUF2570  55 qerqavekqqkianelkakveeekeevktilkqesCakvalPr 97 
                  e   v ++ ++a+  ++++e+ ++e+k  l++  C +v+l +
  EFC37134.1 615 REEMVVFYIINSADYCQQNIEMVQDELKETLQEPYCDQVDLSE 657
                 57778889999999**************************975 PP

>> FUSC  Fusaric acid resistance protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.4   0.00048      0.72     164     309 ..      78     239 ..      66     267 .. 0.80
   2 ?   -4.1   0.1       2.8   4.2e+03     209     295 ..     786     874 ..     777     890 .. 0.59

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00048
        FUSC 164 allrdalalaaaalageegaeareaararlaadilalealrsqaayesprirararalrrllsrmlallallsslarllarlraeeaaavpe....laa 258
                  +l ++++  ++ ++++++ e+ +++ + l+ +i+++ + ++q +   ++i  +++ l    + ++  +++l  l+ l  ++++    ++++    +a+
  EFC37134.1  78 DILVAVRKQSSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNITKDIKSLDYGKRNLTVTMTTLKRLHMLVSAVDKLTLYTQKKqykqVAE 176
                 5677777888888888888888899**********************************************************9888777777777999 PP

        FUSC 259 llaelaal............eaaaaaealeaalaalrarlralrraleadadtaalllarlae 309
                 ll+++ +l            + +++  + e   ++lr++l ++ ++l+a  + +++ +++l++
  EFC37134.1 177 LLEAVNELlanfekykssipKVQNLFMRFESVKKSLRDQLFQDFKSLDAHKNSGRENVQQLLS 239
                 999999989999999999987777888888888888888877777777444444444444443 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 2.8
        FUSC 209 yesprirararalrrllsrmlallallsslarllarlraeeaaavpelaalla..elaaleaaaaaealeaalaalrarlralrralea 295
                 ++  +++  ar++    +++  +l++ls+  +l a+   + a+  ++l +l +  el++l++ + ++ le++ ++lr+r   + +++++
  EFC37134.1 786 FDEDDLASFARKVDGKAQKIECILRTLSAPNDLIAETYISLAPNDHSLPELTKilELKELQKNEKQQILEGYQKELRKRQGGDAKDAPQ 874
                 55555666666666666666666666666666666666555555555444332113444466677777777777777777666666663 PP

>> PAH  Paired amphipathic helix repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       2.5   3.7e+03      16      33 ..      93     110 ..      78     113 .. 0.73
   2 ?    5.5   0.0     0.013        19      19      43 ..     166     190 ..     124     191 .. 0.84
   3 ?    2.1   0.0      0.15   2.2e+02       1      16 [.     287     302 ..     287     333 .. 0.88
   4 ?   -1.8   0.1       2.3   3.5e+03      10      33 ..     518     540 ..     507     541 .. 0.74
   5 ?   -2.5   0.0       3.9   5.8e+03       8      17 ..     852     862 ..     852     872 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2.5
         PAH  16 eqidskeVyeqVskLFhd 33 
                 +++d +e  e +++LF++
  EFC37134.1  93 ARRDLEEARETIQSLFKK 110
                 35889999999****985 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.013
         PAH  19 dskeVyeqVskLFhdhpdLlreFnq 43 
                 ++k  y+qV++L++   +Ll  F+ 
  EFC37134.1 166 TQKKQYKQVAELLEAVNELLANFEK 190
                 3445699999999999999999975 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.15
         PAH   1 evYkeFLdiLhdyqke 16 
                 ++Yk   ++L++yq++
  EFC37134.1 287 DRYKWLMKVLKSYQEQ 302
                 5799999*******98 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 2.3
         PAH  10 LhdyqkeqidskeVyeqVskLFhd 33 
                 +++ +  ++ +k++y  V k F++
  EFC37134.1 518 MKSCSALSK-KKTLYDLVEKVFKK 540
                 555555543.88899999999986 PP

  == domain 5  score: -2.5 bits;  conditional E-value: 3.9
         PAH   8 diLhdyqke.q 17 
                 +iL  yqke +
  EFC37134.1 852 QILEGYQKElR 862
                 69999***943 PP

>> DUF489  Protein of unknown function (DUF489)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.3   0.00042      0.63      49     128 ..      51     134 ..      38     140 .. 0.82
   2 ?   -1.8   0.4       1.8   2.7e+03      45      95 ..     167     195 ..     141     239 .. 0.51
   3 ?    5.6   0.5    0.0098        15      14      74 ..     328     389 ..     322     436 .. 0.79
   4 ?   -0.9   0.1      0.95   1.4e+03      54     106 ..     484     539 ..     464     562 .. 0.66
   5 ?    2.5   0.1     0.087   1.3e+02      53     155 ..     664     768 ..     632     778 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00042
                 TTSGGGGHHHHHHHHHHHHT--SCHHH....HHHHHHHHHHHHHHHHHHSTTHHHHHHHHHHTTHHHHTTS-TTSHHHHHHHHH CS
      DUF489  49 ygglanlklGletlleqlekekkkkda....eltryalsllalerkLsknkealaklgerieqierqlehfdllhenvlanlas 128
                 + ++++l++Gle  +  ++k+ ++ d      + +   s ++  r L++ +e++++l ++i++i++++e+ + + +n+++++ s
  EFC37134.1  51 FPNEQALNEGLESSIIKVKKKIQRVDEdilvAVRKQSSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNITKDIKS 134
                 6678889999998777777776654443354667888899******************************99999999887765 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.8
                 HHHHTTSGGGGHHHHHHHHHHHHT--SCHHHHHHHHHHHHHHHHHHHHHST CS
      DUF489  45 tedvygglanlklGletlleqlekekkkkdaeltryalsllalerkLsknk 95 
                  ++ y+++a+l ++++ ll+ +ek k+                      + 
  EFC37134.1 167 QKKQYKQVAELLEAVNELLANFEKYKS----------------------SI 195
                 233333333333333333333333332......................22 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0098
                 HHHHHHHHHS---HHHHHHHHHHHH--S-SSHHHHTTS.GGGGHHHHHHHHHHHHT--SCHH CS
      DUF489  14 klvqqlArtGqadeealetllkslletdpestedvygg.lanlklGletlleqlekekkkkd 74 
                 + vq+l r  +++ ++l t++ s ++++ +  e +y+  ++++ + l++ ++ql++e+k  +
  EFC37134.1 328 AIVQMLQRGNNVSGKTLYTVILSTIKFERDMQERFYDPdESEILVDLQQQKRQLDQEEKLLK 389
                 578888888899************************9999***************9998433 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.95
                 GGHHHHHHHHHHHHT--S...CHHHHHHHHHHHHHHHHHHHHHSTTHHHHHHHHHH CS
      DUF489  54 nlklGletlleqlekekk...kkdaeltryalsllalerkLsknkealaklgerie 106
                 ++++ l+ +++  + + +   +++++l  y+++ ++  + Lsk+k++++ +++  +
  EFC37134.1 484 SMRETLSNIIQKETWDMNseySSSQDLFMYIVESMKSCSALSKKKTLYDLVEKVFK 539
                 45555544444322222211235668888999999999999998888887776555 PP

  == domain 5  score: 2.5 bits;  conditional E-value: 0.087
                 GGGHHHHHHHHHHHHT--SCHHHHHHHHHHHHHH.HHHHHHHSTTHHHHHHHHHHTTHHHHT..TS-TTSHHHHHHHHHHHHHHTGGGSS-----S-CC CS
      DUF489  53 anlklGletlleqlekekkkkdaeltryalslla.lerkLsknkealaklgerieqierqle..hfdllhenvlanlasiYsdtiSklgpriqvkGepe 148
                 + lk G+e l++ l +  +k+  e+++ a + +  +  +    + ++++l++ i  ++++l   hf++  +n++ ++ + Y + i k  ++i   G ++
  EFC37134.1 664 HVLKSGIEVLVHNLMNVMEKQFSEMISVAWGSMDtVGDQSPFISVIMQTLKDAIPFLAKALPitHFKFFCDNFVLSFMANYINNIYKC-KKISLMGAQQ 761
                 568888888888888888877778888777776514455555677899999999999999866699******99999999*****997.58******** PP

                 HHC-HHH CS
      DUF489 149 vLqqeev 155
                 +L +++ 
  EFC37134.1 762 LLVNSRS 768
                 9988764 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   1.2      0.23   3.4e+02     104     189 ..      58     182 ..      56     192 .. 0.54
   2 ?   -3.1   0.0       3.2   4.8e+03      16      29 ..     428     441 ..     392     468 .. 0.72
   3 ?    7.9   0.1    0.0013         2     114     154 ..     609     674 ..     602     734 .. 0.71

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.23
                 TTBSTHHHHHHHHHHHHTTTEEEEEEESCGST....HHHHHHHHHHHHHHHHHHHHHHHHHHHTTT..........................TTEEEEE CS
    GTP_EFTU 104 veGvepqteevlrlalkegvpiivfiNKmDrl....kaelkeiveevkqklsrkeeklekygekge..........................kevpvvf 172
                 +eG e+   +v + +++++  i v++ K        + +l+e  e++++ + +k +++++++e++e                           +   + 
  EFC37134.1  58 NEGLESSIIKVKKKIQRVDEDILVAVRKQSSSgvqaRRDLEEARETIQSLF-KKINEIKSKAEQSEqmvqnitkdiksldygkrnltvtmttLKRLHML 155
                 677778888888888888888888888888776666667777777777666.33333333333333333334444444444443444444332333333 PP

                 EBTTTTB..........THHHHHHHHH CS
    GTP_EFTU 173 gSalkge..........gvktllealv 189
                 +Sa+++           +v +llea+ 
  EFC37134.1 156 VSAVDKLtlytqkkqykQVAELLEAVN 182
                 444444444444444444446666655 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.2
                 HHHHHHHHHHHTTS CS
    GTP_EFTU  16 KtTLtdrLlyktga 29 
                 Kt+++d+Ll++   
  EFC37134.1 428 KTSTLDSLLKEGDG 441
                 77777777754433 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.0013
                 HHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHHHHH.........................H CS
    GTP_EFTU 114 vlrlalkegvpiivfiNKmDrlkaelkeiveevkqklsrk.........................e 154
                  ++l  +e++ ++ +iN +D ++++++++++e+k++l++                           
  EFC37134.1 609 KIKLTDREEMVVFYIINSADYCQQNIEMVQDELKETLQEPycdqvdlseeqgqfyhvlksgievlV 674
                 57888899999999***********************76665555555444444444444433331 PP

>> Goodbye  fungal STAND N-terminal Goodbye domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   1.7     0.027        40      52     115 ..     139     209 ..      89     214 .. 0.45
   2 ?   -2.4   0.0       4.2   6.3e+03      42      69 ..     225     252 ..     206     257 .. 0.65
   3 ?   -3.1   0.2       6.7     1e+04      20      57 ..     847     887 ..     833     897 .. 0.56

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.027
     Goodbye  52 kealkkilspiqllggiaaqgasma.......FgPaslcfnAvsyLikaakkvseiydaieeLfeelsdfl 115
                 k++l+ +++ ++ l  +++ + +++       +      + Av  L+   +k++++  ++++Lf++ + + 
  EFC37134.1 139 KRNLTVTMTTLKRLHMLVSAVDKLTlytqkkqYKQVAELLEAVNELLANFEKYKSSIPKVQNLFMRFESVK 209
                 23333333333333333333322222002222333445677777777777777777777777777776665 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 4.2
     Goodbye  42 eefrekkeklkealkkilspiqllggia 69 
                  ++++ +e++++ l++++  +  lg+ +
  EFC37134.1 225 AHKNSGRENVQQLLSEACLAVDALGDSI 252
                 2344778888888888888888888766 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 6.7
     Goodbye  20 alkelssvedllkqieaekdkfeefr...ekkeklkealkk 57 
                 ++++ + +e  +k++++++  + ++    +   ++++ +++
  EFC37134.1 847 KNEKQQILEGYQKELRKRQGGDAKDApqaSAIGTATKKMEQ 887
                 45555566666677777666444444333333344444443 PP

>> DUF1539  Domain of Unknown Function (DUF1539)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.4    0.0007       1.1      19      94 ..      54     129 ..      31     136 .. 0.90
   2 ?   -2.4   0.0       3.2   4.8e+03      22      69 ..     197     243 ..     180     265 .. 0.73
   3 ?   -2.8   0.1       4.1   6.2e+03      26      41 ..     489     504 ..     457     558 .. 0.55
   4 ?   -2.1   0.0       2.6   3.9e+03      22      50 ..     663     694 ..     653     753 .. 0.62
   5 ?   -1.1   0.1       1.2   1.9e+03      69      91 ..     833     855 ..     816     857 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0007
     DUF1539  19 wkelnrkLekeikklaqnlrdeWkkilkylskkesseveseeaqalfrstlkkllelLkdptiskekKlellkyia 94 
                  + ln+ Le+ i k+++++++  + il ++ k++ss v+ + + + +r t++ l + +++ +   e+ ++++++i 
  EFC37134.1  54 EQALNEGLESSIIKVKKKIQRVDEDILVAVRKQSSSGVQARRDLEEARETIQSLFKKINEIKSKAEQSEQMVQNIT 129
                 4567778****************************************************99999999999999996 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3.2
     DUF1539  22 lnrkLekeikklaqnlrdeWkkilkylskkesseveseeaqalfrstl 69 
                   ++L  + ++++++lrd++++  k l++ ++++  ++ +q l++++l
  EFC37134.1 197 KVQNLFMRFESVKKSLRDQLFQDFKSLDA-HKNSGRENVQQLLSEACL 243
                 33347777888888899999998888888.777777777777777766 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 4.1
     DUF1539  26 LekeikklaqnlrdeW 41 
                 L + i+k +  +++e+
  EFC37134.1 489 LSNIIQKETWDMNSEY 504
                 4444443333333333 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 2.6
     DUF1539  22 lnrkLekeikklaqn....lrdeWkkilkylsk 50 
                 ++  L++ i+ l  n    +++++++++ +   
  EFC37134.1 663 YH-VLKSGIEVLVHNlmnvMEKQFSEMISVAWG 694
                 44.466666666665444466666666665544 PP

  == domain 5  score: -1.1 bits;  conditional E-value: 1.2
     DUF1539  69 lkkllelLkdptiskekKlellk 91 
                 l +l+++L+ ++  k++K+++l+
  EFC37134.1 833 LPELTKILELKELQKNEKQQILE 855
                 5679999************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (906 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2076  (0.11579); expected 358.6 (0.02)
Passed bias filter:                      539  (0.030063); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                        34  (0.00189637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 1.05u 0.30s 00:00:01.35 Elapsed: 00:00:00.54
# Mc/sec: 5082.50
//
Query:       EFC37135.1  [L=519]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-49  168.7   0.0    4.5e-45  153.9   0.0    2.2  2  Pkinase_Tyr      Protein tyrosine kinase
    1.6e-48  165.4   0.0    2.5e-48  164.8   0.0    1.3  1  Pkinase          Protein kinase domain
    0.00051   18.9   0.1    0.00068   18.5   0.1    1.1  1  Pkinase_fungal   Fungal protein kinase
     0.0059   16.5   0.0      0.011   15.7   0.0    1.3  1  APH              Phosphotransferase enzyme family
  ------ inclusion threshold ------
       0.09   12.0   0.0        8.8    5.4   0.0    2.3  2  Fructosamin_kin  Fructosamine kinase


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.9   0.0   1.3e-48   4.5e-45       2     232 ..     226     457 ..     225     467 .. 0.88
   2 !   12.7   0.0   1.6e-05     0.058     233     259 .]     485     511 ..     475     511 .. 0.89

  Alignments for each domain:
  == domain 1  score: 153.9 bits;  conditional E-value: 1.3e-48
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekek 99 
                  ++ kk+GeG  ++V+ gt++      ++kVa+K+lk ++ ++   ++ +ea+i++ ++hpni+ ++gvc+ +++ +ivtey+++G+L+ ++  +++++
   EFC37135.1 226 SIIKKIGEGGAANVYYGTWT------NIKVAIKSLKIDSFDD---DFENEAAILSLIRHPNILTFYGVCLTDKSRYIVTEYMENGSLDRYIFLNKNRA 314
                  6789****************......9********8776666...9*******************************************988887777 PP

                  SBH...HHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE......EEHHH CS
  Pkinase_Tyr 100 ltl...kdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk......ftsks 186
                  l++   k+ + +   + +Gm+yL+s k  ++Hrdl + N+Ll+e+++ k+sDfGL + +  +++ ++ +++   v ++apE++ +++        +k 
   EFC37135.1 315 LNIdlfKSNIGILCGIVDGMQYLHSLKpsIIHRDLKSSNILLDERNTPKVSDFGLVKVL-GNNTISQITKGIGTVYYLAPETFIAEHqienkeEATKL 411
                  775223578999************98767****************************99.77777889999999*******86554445555589999 PP

                  HHHHHHHHHHHHHTTSSGTTTTS.HHHHHHHHHHTTEES-BBTTSBH CS
  Pkinase_Tyr 187 DvWsfGvllwEiftlgespypgl.kneevleklkegkrlekpekcpe 232
                  D++sf++++wE+f    spy+++ ++ +v +++ +g+r + p ++++
   EFC37135.1 412 DIYSFAIIMWELFF-RMSPYHHVkNPFKVPQMVVNGERPQIPFNIEN 457
                  *************9.789*****778899999******999988765 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 1.6e-05
                  HHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 233 elyelmkkcweedpeeRptfselvekl 259
                  +  +l+ +cw+++p +Rptf +++++l
   EFC37135.1 485 KYFSLILQCWNQNPLQRPTFLTIRREL 511
                  56789****************999876 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  164.8   0.0   6.9e-52   2.5e-48       3     258 ..     227     507 ..     225     511 .. 0.89

  Alignments for each domain:
  == domain 1  score: 164.8 bits;  conditional E-value: 6.9e-52
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH..HHSS--HHH CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle..rkgslseee 99 
                  ++k+GeG+ ++Vy ++  +t+ +vA+K +k ++ +++ e    +E +il  ++hpni+++y+v+ +++++y+v+ey+e+g+l++++   ++++l+ + 
  EFC37135.1 227 IIKKIGEGGAANVYYGT--WTNIKVAIKSLKIDSFDDDFE----NEAAILSLIRHPNILTFYGVCLTDKSRYIVTEYMENGSLDRYIFlnKNRALNIDL 319
                 689**************..9*************9998776....9****************************************99876777788876 PP

                 HH...HHHHHHHHHHHHHHHTT..EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH......TTSCBSHHHHHHHHHH CS
     Pkinase 100 ak...kiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl......keneyskkvDvWslGv 185
                  k    i+  i+ g++ylHs +  iiHrDlK++NiL+de++  K++DFGl+k l +++    t+ +gt +YlAPE        +++e  +k D++s ++
  EFC37135.1 320 FKsniGILCGIVDGMQYLHSLKpsIIHRDLKSSNILLDERNTPKVSDFGLVKVLGNNTIsqITKGIGTVYYLAPETFiaehqiENKEEATKLDIYSFAI 418
                 663235899**********88777******************************99876789*************98898877778889********** PP

                 HHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS...............-HHHHHHHHHHT-SSGCCSTTHHHH CS
     Pkinase 186 ilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasei...............seeakdllkkllkkdpkkRltaeel 258
                 i++el+++  p+++ k+  kv +++ + e+ +  ++ e++ +++e+ +i                ++  +l+ ++++++p +R+t+  +
  EFC37135.1 419 IMWELFFRMSPYHHVKNPFKVPQMVVNGERPQIPFNiENDTEIKEWLSIqaleisssdnsfingIKKYFSLILQCWNQNPLQRPTFLTI 507
                 *************999988888888875555444445567777777777999***********999999****************8765 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.1   1.9e-07   0.00068     247     391 ..     160     400 ..     127     421 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.9e-07
  Pkinase_fungal 247 e.............lsskaevklkksesskkvekrsvdssv..stskrsr............................................. 281
                     +              + ++   +++++s +kv++++  ss+  s++k+s+                                             
      EFC37135.1 160 KrlifnmndeedeyYEGSTPNIERSKSSYGKVSEKELVSSLidSEKKKSKhsfsfsssyiipiedisiikkigeggaanvyygtwtnikvaiksl 254
                     14444444555554222222233333444555555555555433333333677888888888888888888888888888888888888888888 PP

  Pkinase_fungal 282 ...........................................lenrvhrrlvispvGk..piekaespkellealrDaIkghrsLflkagiLHr 331
                                                                +en  + r ++ ++ +   i  ++s   +l+++ D  + + sL     i+Hr
      EFC37135.1 255 kidsfdddfeneaailslirhpniltfygvcltdksryivteyMENGSLDRYIFLNKNRalNIDLFKSNIGILCGIVDGMQYLHSLK--PSIIHR 347
                     88888888888888888888888888888888888888888887777777777655554116789*********************8..9***** PP

  Pkinase_fungal 332 DiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeH 391
                     D    Nil+      ++++  ++D+ l k l++ ++ s+  + +GT++++a e     eH
      EFC37135.1 348 DLKSSNILLD-----ERNTPKVSDFGLVKVLGN-NTISQITKGIGTVYYLAPETFI-AEH 400
                     *********9.....56778899****999996.8888889999**9999987765.445 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0     3e-06     0.011     161     196 ..     338     370 ..     330     372 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3e-06
                 -SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 161 pgelptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                 + +l+++++H+Dl++ N+l+d+++++   v Df+++
  EFC37135.1 338 H-SLKPSIIHRDLKSSNILLDERNTPK--VSDFGLV 370
                 4.4789***************999998..9999887 PP

>> Fructosamin_kin  Fructosamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0    0.0024       8.8      24      97 ..     230     301 ..     215     319 .. 0.77
   2 ?    4.2   0.0     0.006        21     174     211 ..     328     365 ..     307     367 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0024
  Fructosamin_kin  24 kveggeineayllseeeqrfFvklne.kealemFeaEaesLealaetqtirvPkvlavGelkdasfLvleyLelk 97 
                      k++ g + + y  +  + ++ +k  +  ++ + Fe+Ea+ L+++++ +   + + + v  ++++ ++v+ey+e +
       EFC37135.1 230 KIGEGGAANVYYGTWTNIKVAIKSLKiDSFDDDFENEAAILSLIRHPN---ILTFYGVCLTDKSRYIVTEYMENG 301
                      555555555555666666677776665888999**********96655...456788999999*********987 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.006
  Fructosamin_kin 174 vervaellskhqpkpsllHGdLWsgNaaltkdgepvif 211
                      +  v+ +   h+ kps++H dL s N+ l++ ++p + 
       EFC37135.1 328 CGIVDGMQYLHSLKPSIIHRDLKSSNILLDERNTPKVS 365
                      5555556667999***************9999887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (519 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       896  (0.0499749); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 2947.02
//
Query:       EFC37136.1  [L=355]
Description: PARP domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-12   47.7   5.2    1.7e-12   47.4   1.8    2.5  2  PARP         Poly(ADP-ribose) polymerase catalytic domain
  ------ inclusion threshold ------
      0.061   14.4   0.6        0.9   10.6   0.0    2.7  3  ART-PolyVal  ADP-Ribosyltransferase in polyvalent proteins
      0.078   12.9   0.8          1    9.3   0.5    2.5  2  SIR2         Sir2 family
       0.41   10.4   4.7       0.86    9.4   4.7    1.4  1  ERM          Ezrin/radixin/moesin family


Domain annotation for each model (and alignments):
>> PARP  Poly(ADP-ribose) polymerase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1      0.57   2.5e+03     121     155 ..     117     152 ..     111     180 .. 0.56
   2 !   47.4   1.8   3.8e-16   1.7e-12      21     144 ..     202     332 ..     191     353 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.57
                 EEEESS--T.GCCGGTT-SEEEE-EEEEEGG.EEET CS
        PARP 121 ikeltkady.lekakkgkksvkgkgktepesivekd 155
                 ++e+ k++  ++++ k+ +s  +k+k + +++  k+
  EFC37136.1 117 MYEYIKKKSmIKNELKKLNSEFSKSKITYCHYFCKE 152
                 666666666345555555555555555553333333 PP

  == domain 2  score: 47.4 bits;  conditional E-value: 3.8e-16
                 EEEEEEEEEEEEETTHHHHCGCCGG...........SS-EEEEEEEE-GG.GHHHHHHH-S--S-TTS-GGGST..TSSSEEEBSSHHHHHGGG--BSS CS
        PARP  21 yklkileifrvqregeaerfqekkk...........lrnrrlLfHGsrlt.nvasilsqGLriappeapvtGym..fGkGiYfAddaskSanYcktsek 105
                    ++ e+ +v ++   ++f+ekk             ++  +LfHG rl+ n+ si++ ++ i  ++ + tG    +GkG+Yf++  s+Sa Y  t   
  EFC37136.1 202 AGFTLNEVTYVCNPYNLKKFNEKKRelakrhnfmldSMKPLILFHGNRLEsNYDSIMKTNFSI-SKVGSNTGNLgyYGKGVYFSSIPSYSAAYAGT--- 296
                 467899999999999999999999889885566655555999******8549*********99.677777888788*****************996... PP

                 S-EEEEEEEEEE--SEEEESS--TGCCGGTT-SEEEE-E CS
        PARP 106 kgsglllLaeValGdikeltkadylekakkgkksvkgkg 144
                     +ll++ V +G+ + l++ ++    ++g++s  +  
  EFC37136.1 297 ---NILLVCLVFTGKAYPLQQITMGCPRQEGYDSHTSPD 332
                 ...9***********999998888666666666665554 PP

>> ART-PolyVal  ADP-Ribosyltransferase in polyvalent proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1      0.78   3.5e+03      80      98 ..     111     129 ..      61     180 .. 0.56
   2 ?   10.6   0.0    0.0002       0.9       5      48 ..     240     296 ..     237     314 .. 0.84
   3 ?    0.4   0.0      0.27   1.2e+03     100     127 ..     321     345 ..     304     348 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.78
  ART-PolyVal  80 efkreekedleeeeelkae 98 
                  +++ e+  ++ +++++ ++
   EFC37136.1 111 MVDGEDMYEYIKKKSMIKN 129
                  3333333333333333322 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.0002
  ART-PolyVal   5 ePlvvYhGtk.ae......fsvFdseksgsag.......kGfyftdskkvaseYaedg 48 
                  +Pl+++hG + ++       + F+ +k gs++       kG+yf++ + +  +Ya + 
   EFC37136.1 240 KPLILFHGNRlESnydsimKTNFSISKVGSNTgnlgyygKGVYFSSIPSYSAAYA-GT 296
                  8********96558888888899999988888999*******************9.33 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.27
  ART-PolyVal 100 kdegydglilekedegdtyivvFepeQi 127
                  ++egyd+       +g++++v F+ +Qi
   EFC37136.1 321 RQEGYDSHTSP---DGYSEVVIFDEDQI 345
                  67899998876...78889999***999 PP

>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.36   1.6e+03      75     122 ..      56     105 ..      21     129 .. 0.61
   2 ?    9.3   0.5   0.00023         1      94     158 ..     130     259 ..     120     267 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.36
                 EEEEEES-SSSHHHHTT-S..SEEETTEEEEEEEETTTSBEEECCGGHCH CS
        SIR2  75 llrliTQNiDgLekkaGsk..kvvelHGslakakcvkcekkldkeelqee 122
                 ll+++  NiD+++ +  +    + +l   +++++  + + ++ + el ++
  EFC37136.1  56 LLAIYSKNIDEINGSEVVLdqSIADLENRFLSVHKEQKSLIFAHPELSNS 105
                 66777888887753322212345555555555555555555555555555 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00023
                 SEEETTEEEEEEEETTTSBEEECCGGHCHHHCCTT.B-TTTCC........................................................ CS
        SIR2  94 kvvelHGslakakcvkcekkldkeelqeeieaekvpecekcgk........................................................ 136
                 ++ +l  +++k k + c++ +++e+ + + + +k+ ec++                                                           
  EFC37136.1 130 ELKKLNSEFSKSKITYCHYFCKEETDFIQKNGNKKDECKSYILrpsvafdpfivtgedfhfrlassflnhanagftlnevtyvcnpynlkkfnekkrel 228
                 566777889999999999999887777666666666666655578888888888888888888888888888888888888888888888899999999 PP

                 .........BEEEEE--CTSB-SHHHHHHHH CS
        SIR2 137 .........llkpdvvfFGealpdklkklie 158
                           +kp + f+G+ l+++++++++
  EFC37136.1 229 akrhnfmldSMKPLILFHGNRLESNYDSIMK 259
                 9999999999999999999999999999887 PP

>> ERM  Ezrin/radixin/moesin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   4.7   0.00019      0.86     124     203 ..      54     143 ..      13     146 .. 0.55

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00019
         ERM 124 ekllealstpsks...eseenveeseteeeeensee..........................esaeletdeveklsleieeeRvtylekskrlqeqLke 193
                 ++ll++ s++ ++   +                  e                          ++ el++  +e+ ++   e+  +y++k+  +++ Lk+
  EFC37136.1  54 RALLAIYSKNIDEingS------------------EvvldqsiadlenrflsvhkeqkslifAHPELSNS-NEDEEMVDGEDMYEYIKKKSMIKNELKK 133
                 33333333333222220..................12223333333344445555544455566788877.5556677778899*************** PP

         ERM 194 Lkseleqlkd 203
                 L+se +++k+
  EFC37136.1 134 LNSEFSKSKI 143
                 ******9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       981  (0.0547158); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 2064.95
//
Query:       EFC37137.1  [L=660]
Description: abc transporter B family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.6e-57  193.5  14.4    8.4e-57  192.9  14.4    1.2  1  ABC_membrane  ABC transporter transmembrane region
    4.5e-36  124.4   0.4    9.1e-36  123.4   0.0    1.8  1  ABC_tran      ABC transporter
    3.3e-07   30.0   0.2    0.00025   20.6   0.0    2.4  2  SMC_N         RecF/RecN/SMC N terminal domain
    0.00066   19.4   0.0     0.0015   18.3   0.0    1.6  1  AAA_29        P-loop containing region of AAA domain
     0.0008   19.7   0.0      0.002   18.4   0.0    1.7  1  AAA_22        AAA domain
     0.0022   18.4   0.3     0.0097   16.3   0.3    2.1  1  AAA_16        AAA ATPase domain
     0.0035   17.1   7.2     0.0097   15.6   0.0    2.2  2  AAA_15        AAA ATPase domain
     0.0047   16.7   0.0      0.027   14.2   0.0    2.2  2  AAA_30        AAA domain
  ------ inclusion threshold ------
      0.015   15.2   0.0      0.043   13.7   0.0    1.7  1  RsgA_GTPase   RsgA GTPase
      0.042   14.7   4.2       0.09   13.7   4.2    1.4  1  DUF1764       Eukaryotic protein of unknown function (DUF1764
      0.045   13.7   0.0       0.24   11.4   0.0    2.2  2  AAA_5         AAA domain (dynein-related subfamily)
      0.078   11.8   0.1       0.26   10.1   0.0    1.8  2  ABC_ATPase    Predicted ATPase of the ABC class
       0.13   12.8   0.2       0.37   11.3   0.0    2.0  2  AAA_18        AAA domain
       0.16   12.2   0.2       0.98    9.7   0.2    2.2  1  SbcCD_C       Putative exonuclease SbcCD, C subunit


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  192.9  14.4   6.5e-60   8.4e-57       2     271 ..      77     352 ..      76     355 .. 0.96

  Alignments for each domain:
  == domain 1  score: 192.9 bits;  conditional E-value: 6.5e-60
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHH........HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHH CS
  ABC_membrane   2 iliillailagvlsplfplvlgrildtlldkgdpet........ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpms 90 
                   +l+ + a+ +gv+ + f +v+g ++++++++  + +        +++  y+ +++++++a +i++++++++ln+++er+ +++r+ +f+++  q+m+
    EFC37137.1  77 FLGSIGAMGTGVIPISFQFVMGDLINVFSPTRADGStvtaaeqkAEIGTYASYFAIIAAAACIANFMSQFFLNWASERIGVAIRSAYFDSLTVQEMG 173
                   667788999**********************5555558899999***************************************************** PP

                   HHHHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane  91 ffdtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEsl 187
                   ffd ++vG l+  l++d+ +++++++ kl +++q+l++fv+g+i+++++gw+++lv+++++pl+il  ++++ +++kl+   +ka++ + s+a+E++
    EFC37137.1 174 FFDIKKVGALTITLSEDITRIQEVYSVKLATLLQNLAQFVVGVILALTSGWQMALVMMSTTPLMILGVVLLGGVIRKLTLSINKANDHSASIATEVM 270
                   ************************************************************************************************* PP

                   HTHHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHH CS
  ABC_membrane 188 sgirtVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailf 271
                    ++rtV+++++ee+++ +++k l++++ agi ka+a+g ++g++  +    +ala+w+G+ lv +g++++g+  +++++  +lf
    EFC37137.1 271 GAMRTVRSMAGEEKERVRYKKDLTKMYLAGIGKAVAQGSTFGVLVGILWGTTALAFWYGGGLVVDGTMNIGS--MLKVFGLTLF 352
                   ************************************************************************..8888776666 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  123.4   0.0   7.1e-39   9.1e-36       1     137 []     420     571 ..     420     571 .. 0.90

  Alignments for each domain:
  == domain 1  score: 123.4 bits;  conditional E-value: 7.1e-39
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH..................HH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren..................es 81 
                 lkn sl++k+g+ va+vG++G+GKSt++ ll + ++p++G++ ldg d+ e++  +l+k+ig+++qep lf ++ +++n                  ++
  EFC37137.1 420 LKNFSLDIKAGQAVALVGPSGSGKSTIVGLLERFYDPAQGKVYLDGVDIAEIDPMWLHKNIGIVTQEPVLFATS-IYKNiayaigeenttmekvieaAK 517
                 79***********************************************************************9.99999*****77766666665555 PP

                 HTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  82 deeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                 ++++++++  l + +  +t +++++ sLSgGqkqrv++arall++pkllllDE+t+
  EFC37137.1 518 SANCHNFIMDLPDGY--NTLLGERGVSLSGGQKQRVCIARALLQNPKLLLLDEATS 571
                 555666666655555..99999999*****************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0     0.003       3.8      25      41 ..     431     447 ..     418     454 .. 0.81
   2 !   20.6   0.0     2e-07   0.00025     110     210 ..     499     612 ..     457     620 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.003
                 SEEEEEESTTSSHHHHH CS
                 xxxxxxxxxxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnll 41 
                 +  a+vGp GSGKs ++
  EFC37137.1 431 QAVALVGPSGSGKSTIV 447
                 45789*********997 PP

  == domain 2  score: 20.6 bits;  conditional E-value: 2e-07
                 EEEETTEEE-HHHHHHHHHCTT-STT.................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx.................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 110 eykingkevtkkevsellesagiske.................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQ 191
                  y+i +++ t ++v e  +sa+ +                   +LSgG+k+ v +a        +   l llDe  +aLD +  + v   l+   k   
  EFC37137.1 499 AYAIGEENTTMEKVIEAAKSANCHNFimdlpdgyntllgergvSLSGGQKQRVCIAR----ALLQNPKLLLLDEATSALDTESESLVQAALDLLMKGRT 593
                 46666666666666666666665555777888888888888889******9777654....345666799***************************** PP

                 EEEE-SSHHHCCC-SCEEE CS
                 xxxxxxxxxxxxxxxxxxx RF
       SMC_N 192 fivislreemlekadklvg 210
                  i+i++r  +++++dk++ 
  EFC37137.1 594 TICIAHRLSTVKNSDKICV 612
                 **************99875 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   1.1e-06    0.0015      16      39 ..     424     447 ..     416     458 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 1.1e-06
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                 +++i+  +a+ l+GpsGsGKST++
  EFC37137.1 424 SLDIKAGQAVALVGPSGSGKSTIV 447
                 567775559*************98 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   1.6e-06     0.002       5     106 ..     430     578 ..     426     599 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.6e-06
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaee................erpevvfvtlpsstsskdllrellralglelka................. 70 
                  + ++++G+sG+GK+t +  l + +d ++   +                ++   +  + p++   ++++++++ a+g+e+ +                 
  EFC37137.1 430 GQAVALVGPSGSGKSTIVGLLERFYDPAQG--KvyldgvdiaeidpmwlHKNIGIVTQEPVLF-ATSIYKNIAYAIGEENTTmekvieaaksanchnfi 525
                 57889*******************975433..36699***********988888999999999.99***********9999999999999999999999 PP

      AAA_22  71 ..........erlsseell.ealeqalrarav...ielliiDEaqh.lr..se 106
                            + +   l   + ++ + ara    ++ll++DEa   l+  se
  EFC37137.1 526 mdlpdgyntlLGERGVSLSgGQKQRVCIARALlqnPKLLLLDEATSaLDteSE 578
                 9999999998666666666688888888888889999******9988866433 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.3   7.6e-06    0.0097      21      51 ..     429     457 ..     417     595 .. 0.69

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 7.6e-06
      AAA_16  21 sgrpelvllsGesGvGKsslvrellralekd 51 
                 +g  ++v l+G+sG+GKs++v  l r +  +
  EFC37137.1 429 AG--QAVALVGPSGSGKSTIVGLLERFYDPA 457
                 44..78***************8877655554 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   4.7      0.12   1.5e+02     118     174 ..      13      70 ..       3      75 .. 0.86
   2 !   15.6   0.0   7.6e-06    0.0097      14      79 ..     420     482 ..     419     652 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.12
      AAA_15 118 tikdkklklkknelsdekisvekkkskkelpkekeeklekekeelkid.kedlkklik 174
                  ikd + + ++++   ++ + +kk++kk  +ke+e+  ++++++lk++ ++++ k+i 
  EFC37137.1  13 QIKDDMKQQQQQQPERKSRNPFKKNKKKAENKETEDIVDTREPNLKFKdSFTIYKIIG 70 
                 466777777888889999999*************************998888888875 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 7.6e-06
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnkekknkkvikiekedleifeniseskdikI 79 
                 lk++++d++      l+G+ +sGKS+i+ +l+ F +      + +++++  d+ + +     k+i I
  EFC37137.1 420 LKNFSLDIKAGqAVALVGPSGSGKSTIVGLLERFYDPA----QGKVYLDGVDIAEIDPMWLHKNIGI 482
                 78999999988899*********************988....5556666655555555444444444 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       6.1   7.8e+03      90     109 ..     165     184 ..     120     193 .. 0.72
   2 !   14.2   0.0   2.1e-05     0.027      19     112 ..     431     584 ..     425     594 .. 0.64

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 6.1
      AAA_30  90 tllivDEagmvdtkqlaall 109
                 + l v E+g  d+k++ al+
  EFC37137.1 165 DSLTVQEMGFFDIKKVGALT 184
                 67788999999999888886 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 2.1e-05
      AAA_30  19 rvavltGpAGtGKttalkalreaweaa.g..........................grviglApt..gkaAkvLaeelgieastiakllkrlk....... 81 
                 + ++l+Gp G+GK+t+++ l++ ++ a g                          +  +++A +  ++ A +++e    e  t++k++++ k       
  EFC37137.1 431 QAVALVGPSGSGKSTIVGLLERFYDPAqGkvyldgvdiaeidpmwlhknigivtqE-PVLFATSiyKNIAYAIGE----ENTTMEKVIEAAKsanchnf 524
                 47899*******************99945777777777777777777666666642.222222211333333333....33333333333333334444 PP

      AAA_30  82 .............................grarlepgtllivDEagmvdtkqlaallkaa 112
                                              +ra l++ +ll+ DEa  +  ++ ++l++aa
  EFC37137.1 525 imdlpdgyntllgergvslsggqkqrvciARALLQNPKLLLLDEATSALDTESESLVQAA 584
                 444558888888888888888888888876667777788888888777666666666666 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   3.3e-05     0.043      78     120 ..     408     451 ..     389     462 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.3e-05
                  EEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  78 evllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinall 120
                  ++++ s  + + l++ +  +k  + ++lvG+SG GKSt++  l 
   EFC37137.1 408 DFVYPSRPNATVLKNFSLDIKAgQAVALVGPSGSGKSTIVGLLE 451
                  5555566666667777777776699**************98876 PP

>> DUF1764  Eukaryotic protein of unknown function (DUF1764)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   4.2     7e-05      0.09      13      75 ..       6      67 ..       2      71 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 7e-05
     DUF1764 13 eifseskkkkkekekeeeeeekekkkkskkkkkkkkkkeeekkfedseskkrrktedGlpvYt 75
                e++ + ++ k +++++++++ ++k ++  kk+kkk +++e ++++d + +++ k +d +++Y+
  EFC37137.1  6 ELVVDVQQIKDDMKQQQQQQPERKSRNPFKKNKKKAENKETEDIVDTR-EPNLKFKDSFTIYK 67
                666667777777887777777777777777777777777777888887.89***********8 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00018      0.24       2      23 ..     433     454 ..     432     464 .. 0.83
   2 ?   -1.5   0.0       1.7   2.2e+03      41      79 ..     535     574 ..     510     612 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00018
                 EEEE--SSSSHHHHHHHGGGGB CS
       AAA_5   2 vlLvGppGtgKselaerlaaal 23 
                 v LvGp+G+gKs+++  l +++
  EFC37137.1 433 VALVGPSGSGKSTIVGLLERFY 454
                 67***************99987 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.7
                 HH--B--.........--------.G-SEEEEESGGG--H CS
       AAA_5  41 lkgrreikngttslvdsplvraar.egeilvlDEveraes 79 
                 l+g+r ++ ++ + +  ++ ra   ++++l+lDE + a +
  EFC37137.1 535 LLGERGVSLSGGQKQRVCIARALLqNPKLLLLDEATSALD 574
                 5555555533333333444444434888888888876643 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.1   2.7e+03     242     265 ..     427     451 ..     425     455 .. 0.80
   2 ?   10.1   0.0    0.0002      0.26     299     352 ..     518     572 ..     510     584 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.1
                 E-SS.EEEEEE-TTSSHHHHHHHHH CS
  ABC_ATPase 242 ipkG.vtlIvGggfhGKsTLLeAle 265
                 i+ G  +++vG+   GKsT++  le
  EFC37137.1 427 IKAGqAVALVGPSGSGKSTIVGLLE 451
                 7777777899*********987665 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.0002
                 EE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS- CS
  ABC_ATPase 299 gvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsA 352
                 +++  +Fi +LP g +t         SG   q + i++al  + kllL+DE tsA
  EFC37137.1 518 SANCHNFIMDLPDGYNTLlGERGVSLSGGQKQRVCIARALLQNPKLLLLDEATSA 572
                 678899***********955566678****************************9 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       7.8     1e+04     116     128 ..      36      48 ..       5      63 .. 0.66
   2 ?   11.3   0.0   0.00029      0.37       1      20 [.     433     452 ..     433     528 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 7.8
      AAA_18 116 eeakikeneeaei 128
                 +++k++en+e e+
  EFC37137.1  36 KNKKKAENKETED 48 
                 2222235555554 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00029
      AAA_18   1 IlltGtpGvGKttlakeLsk 20 
                 ++l G++G+GK+t+   L++
  EFC37137.1 433 VALVGPSGSGKSTIVGLLER 452
                 6899************9954 PP

>> SbcCD_C  Putative exonuclease SbcCD, C subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.2   0.00077      0.98      31      82 ..     541     579 ..     519     588 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00077
     SbcCD_C  31 gtlSGGekqflaylalaaalaalyssaegrepalrlvfLDEAFsklDeesia 82 
                  +lSGG+kq    +++a   +al++       +++l++LDEA s lD es +
  EFC37137.1 541 VSLSGGQKQ---RVCIA---RALLQ-------NPKLLLLDEATSALDTESES 579
                 566666663...45555...33333.......489************99754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (660 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1871  (0.104356); expected 358.6 (0.02)
Passed bias filter:                     1053  (0.0587317); expected 358.6 (0.02)
Passed Vit filter:                       125  (0.00697194); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.89u 0.34s 00:00:01.23 Elapsed: 00:00:00.51
# Mc/sec: 3926.78
//
Query:       EFC37138.1  [L=1164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-06   26.5   0.1      0.038   14.0   0.0    3.5  3  Kelch_4   Galactose oxidase, central domain
    4.9e-06   26.4   0.0    1.6e-05   24.8   0.0    2.0  1  Kelch_5   Kelch motif
    0.00037   20.7   0.0      0.059   13.7   0.0    2.9  2  Kelch_3   Galactose oxidase, central domain
      0.006   16.8   0.4      0.044   14.1   0.0    2.6  3  Kelch_6   Kelch motif
  ------ inclusion threshold ------
      0.014   15.2   0.0       0.12   12.2   0.1    2.4  2  CDC48_2   Cell division protein 48 (CDC48), domain 2


Domain annotation for each model (and alignments):
>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.21   7.4e+02       5      24 ..     757     775 ..     755     794 .. 0.74
   2 !   14.0   0.0     1e-05     0.038       4      44 ..     815     860 ..     813     868 .. 0.90
   3 !    7.4   0.0    0.0013       4.5       4      44 ..     871     912 ..     870     919 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.21
     Kelch_4   5 hsatsipdgtiylfGGrged 24 
                 +++++  d+ ++l GG+ ++
  EFC37138.1 757 ATTFYM-DDFVILQGGCDTQ 775
                 567777.69********986 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 1e-05
     Kelch_4   4 ghsatsipdgtiylfGGrgedg.....tllndlylldlstntWrrl 44 
                 +hsa    ++++ l+GG + d      ++ln+l  l+l+t +W+ +
  EFC37138.1 815 HHSANIYENDKLLLYGGLNYDSqqkkfSSLNNLIQLNLKTFEWEYI 860
                 689999999************9*********************855 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0013
     Kelch_4   4 ghsatsipdgtiylfGGrgedgtllndlyll..dlstntWrrl 44 
                 +h++t+   +++++ GG+ + + +    yl+  +l t  Wr++
  EFC37138.1 871 YHTSTQA-HDSLFICGGCHSSTRITEYPYLWelNLYTLFWRKI 912
                 9******.59**********98777777996559999999998 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   0.0   4.4e-09   1.6e-05       1      42 []     809     855 ..     809     855 .. 0.84

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 4.4e-09
     Kelch_5   1 iPppRaghcavtv.sekiYvyGGkvg..rdgsvs..ddvyvLdlpsf 42 
                 +P ++++h+a ++ ++k+++yGG ++  +++++s  +++ +L+l++f
  EFC37138.1 809 HPLSIYHHSANIYeNDKLLLYGGLNYdsQQKKFSslNNLIQLNLKTF 855
                 69********87637**********99955555446*********99 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.0   1.6e-05     0.059       1      48 [.     823     876 ..     823     877 .. 0.85
   2 ?    3.7   0.0     0.021        77       2      34 ..     879     912 ..     879     922 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.6e-05
     Kelch_3   1 gdrlyifGGlgd..dgqdrl..ndvyvydldtntWa..eiaslppaRaghaata 48 
                 +d+l+++GGl+   +  +++  n++  ++l t +W+  e+ +  p  ++h++t+
  EFC37138.1 823 NDKLLLYGGLNYdsQQKKFSslNNLIQLNLKTFEWEyiETKNEGPSLYYHTSTQ 876
                 799*********5433333378**************8899************97 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.021
     Kelch_3   2 drlyifGGlgd.dgqdrlndvyvydldtntWaei 34 
                 d+l+i GG+   ++ + +  +++++l t  W++i
  EFC37138.1 879 DSLFICGGCHSsTRITEYPYLWELNLYTLFWRKI 912
                 679*******98889999******9977766666 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       4.3   1.6e+04      23      39 ..     774     794 ..     755     798 .. 0.62
   2 !   14.1   0.0   1.2e-05     0.044       4      44 ..     815     861 ..     813     867 .. 0.90
   3 ?   -1.7   0.1       1.1   4.1e+03       4      19 ..     871     886 ..     869     891 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.3
     Kelch_6  23 s....spylnkvwvydpetks 39 
                       +++  +++y++++++
  EFC37138.1 774 TqvneIQPQTTLLIYSIKDRK 794
                 334666677788889888876 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 1.2e-05
     Kelch_6   4 ghslvsvgg.kiYifGGytds.....spylnkvwvydpetksWeqlp 44 
                 +hs+ ++ + k+ ++GG++ +     +++ln ++ ++++t  We ++
  EFC37138.1 815 HHSANIYENdKLLLYGGLNYDsqqkkFSSLNNLIQLNLKTFEWEYIE 861
                 6899888866*********99***********************986 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.1
     Kelch_6   4 ghslvsvggkiYifGG 19 
                 +h+++ + ++++i+GG
  EFC37138.1 871 YHTSTQAHDSLFICGG 886
                 799999999******9 PP

>> CDC48_2  Cell division protein 48 (CDC48), domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   3.2e-05      0.12       6      63 ..     285     356 ..     280     357 .. 0.91
   2 ?   -0.7   0.0      0.35   1.2e+03      14      46 ..     530     562 ..     522     568 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 3.2e-05
                 CCHHHHCCCTTEEE-TTEEEEECCT.........CCCEEEEEEEECCCC.....SCEEECTSCCEEESTTCC CS
     CDC48_2   6 emaylkrqFlgrpvtkGdlvvfefk.........gqeiklvVvstePkg.....pvgitetTeielgtkpve 63 
                 + + +++++ g ++ k ++v +e++            i++ V + + +        +it +T+i+++ +p+ 
  EFC37138.1 285 FSQFVQKYLIGNVFKKDQRVGMEYLtkngnskkkKEMIEFIVSNLTFSKndislFGIITSNTSIDIELRPTT 356
                 45589*******************8888888999999*********999****999***********99996 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.35
                 CTTEEE-TTEEEEECCTCCCEEEEEEEECCCCS CS
     CDC48_2  14 FlgrpvtkGdlvvfefkgqeiklvVvstePkgp 46 
                 F+ + +  G+ ++f+     i+ +V s+  +g+
  EFC37138.1 530 FQYHYFEIGQELAFSLEYSIIRMKVISINGVGV 562
                 56677788999999999999********99985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1450  (0.0808746); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.87u 0.33s 00:00:01.20 Elapsed: 00:00:00.52
# Mc/sec: 6746.38
//
Query:       EFC37139.1  [L=399]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.041   13.7   2.2      0.061   13.2   0.0    2.5  4  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0      0.78   1.4e+04      14      22 ..     147     156 ..     144     158 .. 0.77
   2 ?   13.2   0.0   3.4e-06     0.061       2      29 ..     176     204 ..     175     204 .. 0.86
   3 ?   -2.5   0.2      0.28   5.1e+03       4      13 ..     232     241 ..     229     251 .. 0.65
   4 ?   -2.9   0.0      0.37   6.7e+03      22      27 ..     365     370 ..     364     371 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 0.78
      RCC1_2  14 LtedGe.Vlc 22 
                 Lt +G+ V++
  EFC37139.1 147 LTKSGIyVYA 156
                 8999988876 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.4e-06
      RCC1_2   2 ksvsaG.dyHscaLtedGeVlcWGsNsdG 29 
                 +++sa  ++  ++Lt+++++l++G+N +G
  EFC37139.1 176 VDISASfVDNLLILTSENRILTTGWNKFG 204
                 678888448889**************998 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.28
      RCC1_2   4 vsaGdyHsca 13 
                 + +G+++s+ 
  EFC37139.1 232 IVSGSCFSLY 241
                 6677777764 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 0.37
      RCC1_2  22 cWGsNs 27 
                 c GsNs
  EFC37139.1 365 CVGSNS 370
                 99**98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       679  (0.0378716); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 2580.60
//
Query:       EFC37140.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-18   66.3   0.1    1.3e-08   34.7   0.1    2.3  2  ADH_N_2       N-terminal domain of oxidoreductase
    1.9e-13   50.5   0.0    3.2e-13   49.8   0.0    1.4  1  ADH_zinc_N    Zinc-binding dehydrogenase
    1.3e-08   36.0   0.0    5.5e-08   33.9   0.0    2.0  2  ADH_zinc_N_2  Zinc-binding dehydrogenase
    0.00046   19.7   0.3    0.00071   19.1   0.3    1.3  1  adh_short     short chain dehydrogenase


Domain annotation for each model (and alignments):
>> ADH_N_2  N-terminal domain of oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.5   0.0   1.2e-10   5.3e-07       1      52 [.       7      63 ..       7      81 .. 0.80
   2 !   34.7   0.1   2.9e-12   1.3e-08      60     101 ..      89     130 ..      77     137 .. 0.88

  Alignments for each domain:
  == domain 1  score: 29.5 bits;  conditional E-value: 1.2e-10
     ADH_N_2  1 kqwvlkkrpegaptesdfelee..eelp...elkdGevlvralylSvDPymRgrmnd 52
                ++++l  rpe +p+  +f+l e  +e+     l++Ge+lv++l+lSvDPy  + m +
  EFC37140.1  7 RRILLVARPENTPKSAHFTLSEpvQEINsetCLNEGEILVKTLFLSVDPYLLMPMGR 63
                7899***************987443333223699****************9877754 PP

  == domain 2  score: 34.7 bits;  conditional E-value: 2.9e-12
     ADH_N_2  60 velgdvmrggavgeVveSknpdfkvGdlVvgllgwqdyavsd 101
                  ++gdv  g +vg+Vv++k++d+kvGdlV++   wq+ya+ +
  EFC37140.1  89 ANVGDVFGGRGVGHVVATKHDDYKVGDLVAADYRWQEYAIIS 130
                 579***********************************9865 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.8   0.0   7.1e-17   3.2e-13       2     109 ..     193     307 ..     192     334 .. 0.71

  Alignments for each domain:
  == domain 1  score: 49.8 bits;  conditional E-value: 7.1e-17
                 HHHHHHHHHHHTT-EEEEEESSHHHHHHHHH.TTESEEEETTTC.H....HHHHHHHHTTTSSEEEEEESSCSHHHHHHHHHCEEEEEEEEECSC.... CS
  ADH_zinc_N   2 vGlaavqlAkalGaeviavdsseeklelakk.lGadevinykea.d....lverikeltggegvdvvfecvGsgatleaalkllkpgGrlvvvGg.... 90 
                 +Gl + qlAk  G++v+++++ eek+e++ + +  d+v++yk+a      l++ +ke+  ++gvd+ f+ vG g + +a ++ l+ + r+ ++G+    
  EFC37140.1 193 IGLTVAQLAKNKGFRVVGIAGGEEKCEKLISeFKLDAVVDYKKAnGdltlLSQLLKEAA-PNGVDAFFDNVG-GLVADAVYENLNLNARVYFCGAisqy 289
                 8*************************777666*********666436885566666666.************.**********************8743 PP

                 TSSEEE...EEHHHHHHTT-EE CS
  ADH_zinc_N  91 gkgeee...fdlrnlllkeksi 109
                 g+g  +    +      ++ +i
  EFC37140.1 290 GEG--KsvlAPE--KYTNNPNI 307
                 333..3433222..22333333 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.1   4.8e+03     104     119 ..      70      86 ..      68      96 .. 0.83
   2 !   33.9   0.0   1.2e-11   5.5e-08       4     132 ..     228     367 ..     225     368 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.1
                   --EEEE.EEGGGHHHHH CS
  ADH_zinc_N_2 104 pvvdrv.fpleeaaeAh 119
                   +v++++ +pl++ ++A 
    EFC37140.1  70 VVPNQTpYPLKQFKDAA 86 
                   6788999******9995 PP

  == domain 2  score: 33.9 bits;  conditional E-value: 1.2e-11
                   SEEEETT..STTHH......HHH-TT-EEEEEES-HHHHH.HHHHHHEEEEEEEEE----.....S-EEE-CHHHCTTT-EEEE--GGG...-.... CS
  ADH_zinc_N_2   4 devidyr..tedfe......aatggegvDvvldtvggealleaslkvlpggGrlvsiggpp....lsaallkpakkrkgrsvkyeflfsmkas...a 85 
                   d v+dy+  + d++      +++ ++gvD+ +d+vgg  + +a+ + l+ ++r+   g+ +      + +l+p+k  ++++++  + +  +a+   +
    EFC37140.1 228 DAVVDYKkaNGDLTllsqllKEAAPNGVDAFFDNVGGLVA-DAVYENLNLNARVYFCGA-IsqygEGKSVLAPEKYTNNPNITSITCL--QADyinN 320
                   89999995445555***99977779***********8877.888888866677633331.1122345666667666666666666666..4445994 PP

                   -HHHHHHHHHHHHHHH----EEEEEEGGGHHHHHHHHHSS--SSEEE CS
  ADH_zinc_N_2  86 qadileelaalieeGklrpvvdrvfpleeaaeAhrylesgrarGKiV 132
                     ++ +el++li++G+l+pv   + ++e++++ ++ + +gr +GK  
    EFC37140.1 321 IPQARRELFELIQKGQLKPVEWITKGIEQTPKVFEEMYAGRNFGKTL 367
                   44448*****************9**********************75 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.3   1.6e-07   0.00071       1      87 [.     182     264 ..     182     283 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 1.6e-07
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT.TSEEEEEE-TTTSHHHHHHHHHHHHHHH..SSESEEEE---S CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee.gakalaiqvDvtdreevealvekavkkl..gkldvLvnNAGi 87 
                 k+++v  a++ IG+ +a+   ++G++vv ++  eek+e++++e+k +   ++  +++D+t        +++  k+    ++d++  N+G 
  EFC37140.1 182 KTIVVSAAAGSIGLTVAQLAKNKGFRVVGIAGGEEKCEKLISEFKLDaVVDYKKANGDLTL-------LSQLLKEAapNGVDAFFDNVGG 264
                 7899****************************************97655555555666653.......3333333323555666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       455  (0.0253779); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 2230.83
//
Query:       EFC37141.1  [L=199]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.7e-45  153.9   0.3    3.7e-45  153.5   0.3    1.1  1  Arf              ADP-ribosylation factor family
    2.9e-14   52.9   0.1    3.5e-14   52.6   0.1    1.2  1  SRPRB            Signal recognition particle receptor beta su
    2.3e-13   50.4   0.1    3.8e-13   49.7   0.1    1.3  1  Roc              Ras of Complex, Roc, domain of DAPkinase
    6.2e-12   45.4   0.0    8.9e-12   44.9   0.0    1.2  1  Ras              Ras family
    1.4e-09   37.6   1.8    9.3e-08   31.6   0.5    2.2  2  G-alpha          G-protein alpha subunit
    2.4e-08   33.6   0.1    3.2e-08   33.2   0.1    1.2  1  Gtr1_RagA        Gtr1/RagA G protein conserved region
    5.7e-08   32.8   0.0    1.1e-07   32.0   0.0    1.4  1  MMR_HSR1         50S ribosome-binding GTPase
    0.00035   20.5   0.1    0.00056   19.9   0.1    1.3  1  NACHT            NACHT domain
    0.00074   19.8   0.1     0.0017   18.6   0.1    1.6  1  AAA_22           AAA domain
     0.0013   18.4   0.3       0.34   10.5   0.0    2.2  2  cobW             CobW/HypB/UreG, nucleotide-binding domain
     0.0072   16.2   0.3        1.1    9.2   0.1    2.7  3  RsgA_GTPase      RsgA GTPase
     0.0082   15.8   0.5      0.039   13.6   0.0    2.1  2  Thymidylate_kin  Thymidylate kinase
  ------ inclusion threshold ------
      0.024   14.4   0.3        2.5    7.8   0.0    2.3  2  ATP_bind_1       Conserved hypothetical ATP binding protein
      0.042   14.3   0.0      0.072   13.5   0.0    1.4  1  AAA              ATPase family associated with various cellul
       0.06   13.9   0.1      0.097   13.2   0.1    1.4  1  ABC_tran         ABC transporter
       0.11   12.7   1.4       0.15   12.3   0.1    1.9  3  VWA              von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.5   0.3   3.3e-48   3.7e-45      16     173 ..       8     176 ..       5     178 .. 0.92

  Alignments for each domain:
  == domain 1  score: 153.5 bits;  conditional E-value: 3.3e-48
                 EEEEEESTTSSHHHHH.......HHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT.THHHHHHHHHH CS
         Arf  16 rilllGLDnaGKtTil.......kklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre.RleeakeeLka 106
                   l+lG+D+aGKtTi+       k+lk+e+++ ++PT+g ++++ ++++++f  wD  G+e+lR+ W +Y+++ ++++fvvDs+d++ Rlee ke L++
  EFC37141.1   8 NTLFLGIDGAGKTTIIntgmnkfKQLKQEQIDAIQPTLGHDSKRFTVEGVEFISWDFPGKEQLRSTWTSYYKHAQVIVFVVDSSDSDeRLEEVKEILHS 106
                 579************833333334799999999***************************************************9865*********** PP

                 HCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGG....SSSSSSEEEEEEBTTTTBTHHHHHHHHHH CS
         Arf 107 lleeeelkevallvlaNKqDlpealseeelrellglee....lkgkrkleiqkcsavkgeglkeglewlse 173
                 ++++ +l+e+ ll+l+NKqDl+++ + ++l+++lgl      l+ +r+++i +c+a +g+gl+++++wls 
  EFC37141.1 107 IIQNVQLRECLLLILGNKQDLNSTRNLDKLKDTLGLGGnlsgLR-DRTWKILTCTAKTGDGLEDAFKWLST 176
                 ***********************************987655577.************************97 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.6   0.1   3.1e-17   3.5e-14       6     137 ..       9     140 ..       6     194 .. 0.80

  Alignments for each domain:
  == domain 1  score: 52.6 bits;  conditional E-value: 3.1e-17
                 EEEE-STTSSHHHHHHHHHHS..S---B---S.S-EEETTG.....GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHH CS
       SRPRB   6 vllvGlsdsGKTslftrLttd..svkktvtSq.essaalkv..ksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEll 99 
                  l++G+  +GKT++++  +++  + k+ ++   ++++ ++    + +g ++   DfPG+e+lr+  + +    ++++ +vfvvDS+  + +++ev E l
  EFC37141.1   9 TLFLGIDGAGKTTIINTGMNKfkQLKQEQIDAiQPTLGHDSkrFTVEGVEFISWDFPGKEQLRSTWTSY---YKHAQVIVFVVDSSDSDERLEEVKEIL 104
                 5899***********998888665555555544888888872235667777777**********99988...566889********************* PP

                 HHHHHHHHHHTT---EEEEEE-TTSTT---HHHHHHHH CS
       SRPRB 100 yeilliteklkdavdiliACnKqelflakspklikdaL 137
                  +i+ ++++   +  +li  nKq+l  +++  ++kd L
  EFC37141.1 105 HSIIQNVQL--RECLLLILGNKQDLNSTRNLDKLKDTL 140
                 ***988874..34679999****************997 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.7   0.1   3.4e-16   3.8e-13       3     119 ..      10     126 ..       8     127 .. 0.71

  Alignments for each domain:
  == domain 1  score: 49.7 bits;  conditional E-value: 3.4e-16
                 EEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHH....HCHHH CS
         Roc   3 vlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrss....enlke 97 
                 +++G  g+GKt++++  +++  + k++++ +++    ++    + +++ +v+ v++  WD+ G+e+ rs+ ++y+++a+++++v+ds++s    e++ke
  EFC37141.1  10 LFLGIDGAGKTTIINTGMNKFKQLKQEQIDAIQ---PTLG---HDSKRFTVEGVEFISWDFPGKEQLRSTWTSYYKHAQVIVFVVDSSDSderlEEVKE 102
                 689***************654444444443333...3331...122334567799*******************************5543222356778 PP

                 HHHHHHHHCS..SS-EEEEEE-TT CS
         Roc  98 Wlkelkkvag..kspvilvgnkiD 119
                  l+++ ++++  ++ ++++gnk D
  EFC37141.1 103 ILHSIIQNVQlrECLLLILGNKQD 126
                 88887776653245567899**99 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.9   0.0     8e-15   8.9e-12       3     160 ..      10     178 ..       8     180 .. 0.74

  Alignments for each domain:
  == domain 1  score: 44.9 bits;  conditional E-value: 8e-15
                 EEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEET.....TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEET.TBHHHHHTHHHHHH CS
         Ras   3 vlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievd.....gkevkleiwDTAGqeefkslrelyyrdaegillvydi.tsresfenvkkwve 95 
                 +++G  + GKt++++  + +kFk+ +++ i  d  + ++  d      + v++  wD  G+e+ +s  ++yy++a++i+ v d  +s e +e+vk++++
  EFC37141.1  10 LFLGIDGAGKTTIINTGM-NKFKQLKQEQI--DAIQPTLGHDskrftVEGVEFISWDFPGKEQLRSTWTSYYKHAQVIVFVVDSsDSDERLEEVKEILH 105
                 679999******998755.56666655555..44444444441111145577889*********************9887766514566799***9999 PP

                 HHHHHST.TTSEEEEEEETTTGGGG-SS-HHHHHHHH........HHHTSEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  96 eikrvae.envpivLvGnKvDleekravsteegeela........kelglkfletSAktnenveeafeellrei 160
                  i + ++ +++ ++++GnK Dl+++r++++ +   l         ++   k l ++Akt  ++e+af+ l +e 
  EFC37141.1 106 SIIQNVQlRECLLLILGNKQDLNSTRNLDKLKDT-LGlggnlsglRDRTWKILTCTAKTGDGLEDAFKWLSTET 178
                 99999998889*************8888765422.11234444667888999***************9987765 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.1    0.0036       4.1      24      42 ..       7      25 ..       3      38 .. 0.75
   2 !   31.6   0.5   8.3e-11   9.3e-08     173     281 ..      29     127 ..      25     193 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0036
                EEEEEEESTTSSHHHHHHH CS
     G-alpha 24 vkllllGqseSGKsTilkq 42
                v+ l+lG ++ GK+Ti++ 
  EFC37141.1  7 VNTLFLGIDGAGKTTIINT 25
                789*************653 PP

  == domain 2  score: 31.6 bits;  conditional E-value: 8.3e-11
                 T----CHHHHCS-----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSE CS
     G-alpha 173 dYlptddDilkarlktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntp 271
                 +++  ++  + a ++t+G    +f v+ ++ef  +d  G+ + r +W ++++ +++i+F+v  s+ d+         rlee  ++ ++i++n  l+++ 
  EFC37141.1  29 KFKQLKQEQIDAIQPTLGHDSKRFTVE-GVEFISWDFPGKEQLRSTWTSYYKHAQVIVFVVDSSDSDE---------RLEEVKEILHSIIQNVQLRECL 117
                 56666777888999************9.*********************************9777666.........8888999999999999999999 PP

                 EEEEEE-HHH CS
     G-alpha 272 iiLflnKlDi 281
                 ++++ nK D+
  EFC37141.1 118 LLILGNKQDL 127
                 9999999996 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.2   0.1   2.8e-11   3.2e-08       3     125 ..      10     129 ..       8     140 .. 0.80

  Alignments for each domain:
  == domain 1  score: 33.2 bits;  conditional E-value: 2.8e-11
   Gtr1_RagA   3 LLmGksgsGKtsmrsi...iFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletl 98 
                 L++G  g+GKt++ +     F+++  +++  ++ t  ++ +++ +++ +++  wD++G+e++  +       + +++ +v+++V+D++  + +e le+ 
  EFC37141.1  10 LFLGIDGAGKTTIINTgmnKFKQLKQEQIDAIQPTLGHDSKRF-TVEGVEFISWDFPGKEQLRSTW-----TSYYKHAQVIVFVVDSS--DSDERLEEV 100
                 89**********99863335999999****************9.67889999******99987664.....6678999*********9..888999999 PP

   Gtr1_RagA  99 keilealrqysp..eakvfvlihKmDliq 125
                 keil+ + q+ +  e  + +l +K Dl +
  EFC37141.1 101 KEILHSIIQNVQlrECLLLILGNKQDLNS 129
                 99999998886511444555557887765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.0   0.0   9.4e-11   1.1e-07       3     102 ..      10     105 ..       8     124 .. 0.69

  Alignments for each domain:
  == domain 1  score: 32.0 bits;  conditional E-value: 9.4e-11
                 EEEESTTSSHHHHHHHHHTS....TEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT..TTCSHHHH CS
    MMR_HSR1   3 aivGrpNvGKStLinaltge....kaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas..eeklkpld 94 
                 +++G   +GK+t+in+ +++    k +  d  + T+    +r++++g e++ +D pG       +++l+ ++ +  + a++i++vvd+s  +    +  
  EFC37141.1  10 LFLGIDGAGKTTIINTGMNKfkqlKQEQIDAIQPTLGHDSKRFTVEGVEFISWDFPG-------KEQLRSTWTSYYKhAQVIVFVVDSSdsD----ERL 97 
                 689999************98543333444444666666666677779**********.......458999999988879********77442....333 PP

                 HHHHHHHH CS
    MMR_HSR1  95 eeleelle 102
                 ee++e+l+
  EFC37141.1  98 EEVKEILH 105
                 44444432 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.1     5e-07   0.00056       5     125 ..      11     120 ..       8     140 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 5e-07
                 EEC-TTTCHHHHHHHHHHHHCTS-SCCCC.-SEEEEEETTTTTTS-...-HCHHHCCCCTS--SSS-CCHHHHCCSCCCEEEEEE-STT-SS-TCH... CS
       NACHT   5 lqGeaGsGKTtLlqklalawaegklpqga.fklvFflslrelsrsgnarsladllfsqlpepaapvsevwavllelperlLlilDglDelvtdlgqkek 102
                   G  G GKTt +   + + ++ k++q    +  + + +++++         +++  ++p +++  s+ w+   ++++ +++++D+ D  ++ l++   
  EFC37141.1  11 FLGIDGAGKTTIINTGMNKFKQLKQEQIDaIQPTLGHDSKRFTV-----EGVEFISWDFPGKEQLRST-WTSYYKHAQVIVFVVDSSDSDER-LEE--- 99 
                 67889*******************99954344444444444444.....4568**********99999.*******************9887.555... PP

                 ......HHHHHCTTTTT--EEEE CS
       NACHT 103 qpvrtlLselirkkllpeaslll 125
                   v++ L+++i+   l+e+ ll+
  EFC37141.1 100 --VKEILHSIIQNVQLRECLLLI 120
                 ..7****************9998 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.1   1.5e-06    0.0017      10     116 ..      11     140 ..       8     151 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 1.5e-06
      AAA_22  10 vtGesGtGKTtllrrlleqldeeakaee.................erpevvfvtlpsst....sskdllrellralglelka....erlsseelleale 83 
                   G  G+GKTt +++ ++++++  k+e+                 e++e+++ + p+++    ++++ +++   ++ +  ++    +  + +e+l+ + 
  EFC37141.1  11 FLGIDGAGKTTIINTGMNKFKQL-KQEQidaiqptlghdskrftvEGVEFISWDFPGKEqlrsTWTSYYKHAQVIVFVVDSSdsdeRLEEVKEILHSII 108
                 56899********9999999654.44445888899**99999999999999999999998999999999888888887777777777777788888888 PP

      AAA_22  84 qalraravielliiDEaqhlrseealeeLrsll 116
                 q+++ r    lli+ + q l+s ++l +L++ l
  EFC37141.1 109 QNVQLREC-LLLILGNKQDLNSTRNLDKLKDTL 140
                 88888888.999999999998899998888765 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   0.00031      0.34       4      51 ..      10      57 ..       7      63 .. 0.65
   2 !    6.1   0.1    0.0067       7.5     111     164 ..      80     138 ..      66     141 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00031
                EEEESTTCCHHHHHHHHH...CT--SS-EEEEESS-SSCHCCCCCCHCCCT CS
        cobW  4 vltGflGsGKTtLlnhll...enraglklavivNefgevsiDaellretgv 51
                ++ G  G+GKTt++n+ +   ++ +++++  i   + ++++D+++ + +gv
  EFC37141.1 10 LFLGIDGAGKTTIINTGMnkfKQLKQEQIDAI---QPTLGHDSKRFTVEGV 57
                567888***********944444444444444...4444477776666655 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0067
                 CECEEEEEEETTTH....CCHCCHHHHHHH.....HHHTSSEEEE.E-HHHHCHC..HHHHHH CS
        cobW 111 tldavvavvDaknl...eaeeekieekaed.....qlaaadllvl.nKtDlldeealleklee 164
                  ++++v+vvD++         e+ +e +++     ql  + ll+l nK Dl ++++l +kl++
  EFC37141.1  80 HAQVIVFVVDSSDSderL---EEVKEILHSiiqnvQLRECLLLILgNKQDLNSTRNL-DKLKD 138
                 567899*****9985552...44444333211112666666655569***9998854.77665 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.1   0.00096       1.1     102     124 ..       9      31 ..       5      59 .. 0.80
   2 ?    0.8   0.0      0.37   4.2e+02      62      99 ..      68     106 ..      56     113 .. 0.73
   3 ?    4.3   0.0     0.031        34      36     101 ..     105     178 ..      71     181 .. 0.63

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00096
                  EEEECSTTSSHHHHHHHHCTT-- CS
  RsgA_GTPase 102 svlvGqSGvGKStLinallpele 124
                  ++++G  G+GK+t+in+ +++ +
   EFC37141.1   9 TLFLGIDGAGKTTIINTGMNKFK 31 
                  689*************9766543 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.37
                  HHHHHHHHHHHHHTTSEEEE--TTTH.TTHHHHHHHCTT CS
  RsgA_GTPase  62 eeeleelkeelealgyevllvsaktk.egleelkellkd 99 
                  e+  +++ + ++++++ v++v+++++ e lee+ke l++
   EFC37141.1  68 EQLRSTWTSYYKHAQVIVFVVDSSDSdERLEEVKEILHS 106
                  444677888899999888887665442788888888875 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.031
                  HHHHHHHHHTT-EEEEEEE-GGG--HHH........HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTTSE CS
  RsgA_GTPase  36 drfLvlaeekgiepvivlnKiDlleeee........eleelkeelealgyevllvsaktkegleelkellkdkt 101
                  + ++  ++ ++  ++i+ nK Dl ++++         l    + l++   ++l++ akt++gle+  ++l+ +t
   EFC37141.1 105 HSIIQNVQLRECLLLILGNKQDLNSTRNldklkdtlGLGGNLSGLRDRTWKILTCTAKTGDGLEDAFKWLSTET 178
                  33333444455556677799999998886655444444444556677778888899999999888888887765 PP

>> Thymidylate_kin  Thymidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.0   3.5e-05     0.039       3      24 ..      13      34 ..      11      43 .. 0.88
   2 ?   -0.2   0.1      0.62     7e+02     117     149 ..     167     195 ..     148     199 .] 0.55

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3.5e-05
                     ESTTSSHHHHHHHHHHHHHHTT CS
  Thymidylate_kin  3 GlDGaGKttqaellkerlkeeg 24
                     G+DGaGKtt++++ ++++k+ +
       EFC37141.1 13 GIDGAGKTTIINTGMNKFKQLK 34
                     9************999999876 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.62
                      E-SEEEEEESSHHHHHTSCCTTSSTTTSHHHHH CS
  Thymidylate_kin 117 kPdltflldvdpevalkRlakrdeldeeeeeql 149
                        d++  l+++  +a+k+ + +++    ee+++
       EFC37141.1 167 LEDAFKWLSTETMKAYKKRESKKK----EEKKE 195
                      566666666666666655554444....22222 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.022        24       2      24 ..      12      34 ..      11      41 .. 0.75
   2 ?    7.8   0.0    0.0022       2.5      94     179 ..      60     135 ..      35     145 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.022
  ATP_bind_1  2 vGpaGsGKttfvgalseilelrg 24
                +G  G+GKtt++++ ++ +++ +
  EFC37141.1 12 LGIDGAGKTTIINTGMNKFKQLK 34
                7999********98666555554 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0022
  ATP_bind_1  94 llfDtPGQielfthseslakiveeLesefalvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvl.nkfDllkeklekelef 179
                 +  D PG   l   + s          ++a v+v++vDs  +++  + ++++l ++   ++l+   + +l nk Dl +++   +l+ 
  EFC37141.1  60 ISWDFPGKEQLRSTWTSYY--------KHAQVIVFVVDSSDSDERLEEVKEILHSIIQNVQLRECLLLILgNKQDLNSTR---NLDK 135
                 5568899999999999988........8999************************9999999887777765999997744...3333 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   6.4e-05     0.072       2     119 ..      10     132 ..       9     143 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 6.4e-05
                 EEESSTTSSHHHHHHHHHHHH.................THEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEE.ETGGGHHHHHTTCCCHHH CS
         AAA   2 llyGppGtGKTllakavakel.................gvefleisgsellskyvgesekkirelfkeakekakpsilfi.DEidalaksrsgseseee 82 
                 l+ G  G GKT++++  ++++                 +++ ++++g e++ ++   +++++r ++++  ++a ++i+f+ D  d+          e  
  EFC37141.1  10 LFLGIDGAGKTTIINTGMNKFkqlkqeqidaiqptlghDSKRFTVEGVEFI-SWDFPGKEQLRSTWTSYYKHA-QVIVFVvDSSDSD---------ERL 97 
                 899*****************6333333333333333323668999999999.8999999*********99998.6666650444443.........246 PP

                 HHHHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHH CS
         AAA  83 ervvnqLlteldgvkkkeskvivigatnrpdkldpal 119
                 e+v + L + +++v+ +  ++++++ +n+ d  +   
  EFC37141.1  98 EEVKEILHSIIQNVQLR--ECLLLILGNKQDLNSTRN 132
                 68999999999999984..689999898887765555 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   8.6e-05     0.097      15      92 ..      10     111 ..       7     161 .. 0.58

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 8.6e-05
                 EEEESTTSSHHHHHHHHTTSS--.SEEEEEETTCEGGGB-HHHCCHCEEEE-SS....--S-TTSBHHHH.........................HHHT CS
                 xxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxx.........................xxxx RF
    ABC_tran  15 aivGenGaGKStLlkllagllkp.teGeilldgkdlkeqeleslrkeigvlpqe....pqlfpeltvren.........................esde 83 
                  ++G  GaGK+t++++ +++ k+ ++++i   +  l +++++++ + +++++ +    +ql +      +                         e +e
  EFC37141.1  10 LFLGIDGAGKTTIINTGMNKFKQlKQEQIDAIQPTLGHDSKRFTVEGVEFISWDfpgkEQLRS------TwtsyykhaqvivfvvdssdsderleEVKE 102
                 6899***********966555554888885555555555666666666666655322222222......222233345555555555433333322222 PP

                 CHHHHHHHS CS
                 xxxxxxxxx RF
    ABC_tran  84 eiekalskl 92 
                  ++ +++++
  EFC37141.1 103 ILHSIIQNV 111
                 244444444 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       4.4   4.9e+03      54      71 ..      26      44 ..      17      59 .. 0.58
   2 ?   12.3   0.1   0.00013      0.15       2      32 ..      84     112 ..      84     137 .. 0.91
   3 ?   -3.4   0.0       8.5   9.6e+03      78      98 ..     160     180 ..     156     190 .. 0.63

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 4.4
                ETTSHC.HHHHHHHHHHTG CS
         VWA 54 slndys.skeellsalnnl 71
                 +n+++  k+e ++a++ +
  EFC37141.1 26 GMNKFKqLKQEQIDAIQPT 44
                4555554556666666664 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 0.00013
                 EEEEEE-STTSCHHHHHHHHHHHHHHHHHHT CS
         VWA   2 ivfvlDgSgsmgeenfekvkefikklvekle 32 
                 ivfv+D+S+s  +e++e+vke++ +++++++
  EFC37141.1  84 IVFVVDSSDS--DERLEEVKEILHSIIQNVQ 112
                 8*********..6***************987 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 8.5
                 SC-HHHHHHHHHHHHHHHHGT CS
         VWA  78 ttntgkalkyaleklfkssag 98 
                 t++tg++l+ a + l +++ +
  EFC37141.1 160 TAKTGDGLEDAFKWLSTETMK 180
                 566888888887755555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (199 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1574  (0.0877907); expected 358.6 (0.02)
Passed bias filter:                      658  (0.0367003); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 1142.57
//
Query:       EFC37142.1  [L=342]
Description: RNA ligase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.9e-28   96.8   0.7    5.9e-28   96.8   0.7    2.0  2  T4_Rnl2_C   T4 RNA ligase 2 C-terminal
    6.5e-18   65.5   0.0    1.7e-17   64.2   0.0    1.7  1  RNA_ligase  RNA ligase
     0.0031   17.4   0.6     0.0083   16.0   0.6    1.7  1  DUF4268     Domain of unknown function (DUF4268)


Domain annotation for each model (and alignments):
>> T4_Rnl2_C  T4 RNA ligase 2 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.2       1.1   6.6e+03      54      77 ..      19      38 ..      13      42 .. 0.46
   2 !   96.8   0.7   9.8e-32   5.9e-28       2      81 ..     243     329 ..     242     330 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.1
                HHT...T--SSSSSSHHHHHHHHH CS
   T4_Rnl2_C 54 nkeeeaelsslskeeqkvikkkln 77
                +k++ + +++ ++e    ++kkln
  EFC37142.1 19 RKQYVESIKTQNEE----MSKKLN 38
                34443333333333....444444 PP

  == domain 2  score: 96.8 bits;  conditional E-value: 9.8e-32
                 TS-TTTHHHHHHHGGG--HHHHHHHHHTSS--STTTHHHHHHHHHHHHHHHHHHT..........T--SSSSSSHHHHHHHHHHHHH CS
   T4_Rnl2_C   2 klseeleelleeierYvtenRLnNviSKigeitrknfgkvlkafvqDaledfnkee.......eaelsslskeeqkvikkklnkeiq 81 
                 ++seel ++++e++rY+t+nRL+Nv+SKig++t++n+  v+k+f++Dale+f+ +        ++++ssls+e+qk ++kk+n++++
  EFC37142.1 243 GDSEELVQVWNELSRYITSNRLDNVLSKIGNLTKSNMFPVMKEFSNDALEEFKLDLergalenCKPVSSLSSEDQKKLTKKINDACM 329
                 679**********************************************************************************97 PP

>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.2   0.0   2.9e-21   1.7e-17       2     161 .]      42     221 ..      41     221 .. 0.77

  Alignments for each domain:
  == domain 1  score: 64.2 bits;  conditional E-value: 2.9e-21
                 EEEEEEE-SSEEEEEEEETTEEEEETTCEBCTTTHHHHHHTHHHHHHHHHHHHH..ECCEEEEEEEES............SS.....TT.SS.EEEEEE CS
  RNA_ligase   2 evvvtEKlDGtnfriylvkevgvasRsqilpfgeekfkefkrwaaalrkklkeklaneelilyGElig...........hsi...kygg.lpkefyvFd 85 
                 e++++EK++G+n+++++++ v+                    w + l  +l e+l+ +++++yGEl+g           +      +++  +++fy+Fd
  EFC37142.1  42 EWYCSEKVHGCNLSFIVDR-VRQS-----------------DWRKSLSGELNEQLKLKSVQIYGELFGglfpnkkpsdaK-AiqsGIHYcPHHDFYAFD 121
                 8****************97.4433.................45555567999999*889*********999877655542.045433333567****** PP

                 EEEEECTTBECE--HHHHHHHHHCCT....B..EEEEE.SSHHHHHCCC.........................HHHHTC--EEEEEESSSSBE.TTEB CS
  RNA_ligase  86 ifdirdkeeqrylspdevealakglg....tvpvlyegkflaaeellel........................llskgnkrEGlVikpeselyk.nkgr 155
                 ++   ++ +q +  + +v+ l+++ g      p++++    +++e+le+                          + +n++EG+Vikp++     +++r
  EFC37142.1 122 VLLGFENGKQSWAVFNNVDPLLDECGfkvrAQPLFKG----TLDECLEFdvkfntklpetfypeivkernaswK-DLDNICEGVVIKPTKYNIFvETER 215
                 **766889**********5555545565655566644....5789999999999999999****9998876431.7899**********9999989999 PP

                 SEEEEE CS
  RNA_ligase 156 aifKvk 161
                 a++K k
  EFC37142.1 216 AVIKKK 221
                 999976 PP

>> DUF4268  Domain of unknown function (DUF4268)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.6   1.4e-06    0.0083      61     120 ..      15      68 ..       4      83 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 1.4e-06
     DUF4268  61 deeenkeifekLkeqkeeieeelgeeleWerleekkasrisriyvlkedvdikdkedwpe 120
                 d+  +k++ e +k+q ee+ ++l++++eW  +e+ +++++s+i++ ++      ++dw +
  EFC37142.1  15 DNHYRKQYVESIKTQNEEMSKKLNHPMEWYCSEKVHGCNLSFIVDRVR------QSDWRK 68 
                 67899************************9999*********998777......777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       800  (0.0446204); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 2382.02
//
Query:       EFC37143.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.3e-05   22.7   4.4    6.3e-05   22.7   4.4    4.0  4  LRR_8     Leucine rich repeat
    0.00027   21.3   5.6    0.00027   21.3   5.6    4.9  5  LRR_4     Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
       0.02   14.9   6.3        2.2    8.6   0.9    4.3  4  LRR_6     Leucine Rich repeat


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1      0.86   5.1e+03      49      56 ..      34      41 ..      30      48 .. 0.47
   2 ?    0.5   1.1     0.088   5.2e+02      30      61 .]     314     343 ..     310     363 .. 0.82
   3 !   22.7   4.4   1.1e-08   6.3e-05       2      61 .]     405     463 ..     404     463 .. 0.84
   4 ?    2.7   0.1     0.018     1e+02      22      45 ..     459     482 ..     447     489 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.86
                -S-.EEE- CS
       LRR_8 49 psLrsLdL 56
                + L+ L L
  EFC37143.1 34 NDLENLFL 41
                33333333 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.088
                 EE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  30 LdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L L++ +++t++  +++  + L++L L+++++
  EFC37143.1 314 LALNSANIDTFH--VLHTTKYLTELKLQDCHI 343
                 667777888885..888888888888888876 PP

  == domain 3  score: 22.7 bits;  conditional E-value: 1.1e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + t+L L +N +++++ e   ++++L++LdLsnN+l+ l +++ s   + + L L+gN++
  EFC37143.1 405 SITTLKLGKNEIENIELERLDSMKGLTSLDLSNNKLNDL-KNVQSIIGKFKDLKLNGNPI 463
                 568999999999999999999999999999999999999.58777778888888888875 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.018
                 TT-TT--EEE--SS---GGGGGGG CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgaf 45 
                 +g++  k + ++ N+l++++ ++ 
  EFC37143.1 459 NGNPIFKRMMINKNKLEFINDDCK 482
                 677788889999999999998775 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.63   3.8e+03      16      31 ..      28      42 ..      26      50 .. 0.69
   2 ?    0.8   1.6      0.13   7.6e+02      22      22 ..     372     372 ..     331     404 .. 0.54
   3 !    8.1   1.0   0.00063       3.8       1      42 [.     384     421 ..     384     425 .. 0.87
   4 !   21.3   5.6   4.5e-08   0.00027       2      41 ..     405     445 ..     404     448 .. 0.84
   5 !   13.9   3.2   9.5e-06     0.057       2      33 ..     429     461 ..     428     465 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.63
                -S-HHH-TT--EEE-. CS
       LRR_4 16 iplleklpnLkeLdLs 31
                +p+++ + +L+ L L+
  EFC37143.1 28 LPFFS-FNDLENLFLT 42
                56677.7888888883 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.13
                 - CS
       LRR_4  22 l 22 
                  
  EFC37143.1 372 Q 372
                 2 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.00063
                 SS--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeL 42 
                 p+L++L +++  l++ip ++  ++ ++L L g n i+++ eL
  EFC37143.1 384 PKLTNLTCGDLSLKSIPMIS--KSITTLKL-GKNEIENI-EL 421
                 79*******999******99..9*******.65599998.45 PP

  == domain 4  score: 21.3 bits;  conditional E-value: 4.5e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGG CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdlde 41 
                 + ++L L+ N +  i+l  l +++ L++LdLs+N +++dl +
  EFC37143.1 405 SITTLKLGKNEIENIELerLDSMKGLTSLDLSNN-KLNDLKN 445
                 789**************77779*********555.8888765 PP

  == domain 5  score: 13.9 bits;  conditional E-value: 9.5e-06
                 S--EEE--SS---E-S-HHH.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipllek.lpnLkeLdLsgN 33 
                  L++LdLsnN+l d+ + ++ + + k L L+gN
  EFC37143.1 429 GLTSLDLSNNKLNDLKNVQSiIGKFKDLKLNGN 461
                 79**************98876777888888888 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0    0.0082        49       4      16 ..     332     344 ..     329     350 .. 0.92
   2 ?    1.8   0.0     0.056   3.3e+02       4      16 ..     405     417 ..     403     419 .. 0.86
   3 ?    8.6   0.9   0.00037       2.2       5      17 ..     430     442 ..     427     443 .. 0.93
   4 ?   -3.2   0.0       2.1   1.3e+04       6      15 ..     454     463 ..     453     463 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0082
       LRR_6   4 hLteLdLsgNdIg 16 
                 +LteL L++++I+
  EFC37143.1 332 YLTELKLQDCHID 344
                 7**********96 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.056
       LRR_6   4 hLteLdLsgNdIg 16 
                 ++t+L L  N+I 
  EFC37143.1 405 SITTLKLGKNEIE 417
                 79*********97 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00037
       LRR_6   5 LteLdLsgNdIgD 17 
                 Lt+LdLs N+++D
  EFC37143.1 430 LTSLDLSNNKLND 442
                 9**********98 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 2.1
       LRR_6   6 teLdLsgNdI 15 
                 + L L+gN I
  EFC37143.1 454 KDLKLNGNPI 463
                 5688999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       674  (0.0375927); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 3505.90
//
Query:       EFC37144.1  [L=436]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-06   28.2   0.1    0.00032   20.4   0.0    3.4  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    0.00051   20.6   0.1       0.73   10.5   0.0    2.8  2  RCC1      Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.021   14.7   0.0      0.061   13.2   0.0    1.8  1  BAH       BAH domain


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.036   2.2e+02       8      20 ..     159     171 ..     159     172 .. 0.89
   2 ?    1.3   0.0     0.054   3.2e+02      15      28 ..     207     220 ..     204     221 .. 0.86
   3 !   20.4   0.0   5.3e-08   0.00032       1      30 []     245     274 ..     245     274 .. 0.95

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.036
      RCC1_2   8 dyHscaLtedGeV 20 
                 ++H+++++ed+e+
  EFC37144.1 159 SNHALVVLEDDEL 171
                 59********987 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.054
      RCC1_2  15 tedGeVlcWGsNsd 28 
                 t+ ++++c G+N +
  EFC37144.1 207 TDKNKMFCRGDNRF 220
                 78899*******75 PP

  == domain 3  score: 20.4 bits;  conditional E-value: 5.3e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V +v +G +H+ +++e+  ++ +G+N + Q
  EFC37144.1 245 VQQVKCGLFHTAVMLENKSIYVCGQNKFNQ 274
                 66999*********************9988 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0    0.0015       9.2      36      50 .]     244     258 ..     225     258 .. 0.79
   2 !   10.5   0.0   0.00012      0.73       4      44 ..     264     303 ..     263     308 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0015
                 -EEEEEEETTEEEEE CS
        RCC1  36 rvvkvacGddhtval 50 
                  v++v cG +ht+++
  EFC37144.1 244 LVQQVKCGLFHTAVM 258
                 699*********985 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00012
                 EEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEET CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGd 44 
                 +y +G+n ++q+G  ++e+++  tk++++s+    +  cG+
  EFC37144.1 264 IYVCGQNKFNQCGVSSKEDQSF-TKIQFSSDIIPESLYCGS 303
                 8*************99955532.777777654555555555 PP

>> BAH  BAH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0     1e-05     0.061      61      99 ..       6      51 ..       2      66 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1e-05
                T.TEEEEEEEEEEEEGGGEEEEEEEEEHHHHCTECCHCH......H CS
         BAH 61 k.rElfltrqseilplaairgkcrVvllsdleeaqnylp......k 99
                + + lfl++qs+++ ++ + +kc++v+l +l++++ +++       
  EFC37144.1  6 HqQVLFLSNQSSSMEIDGVFEKCNLVSLHQLTNLEIKKIcpssrnS 51
                4478*******************************99986544440 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (436 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       501  (0.0279436); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.25s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 2859.13
//
Query:       EFC37145.1  [L=347]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-17   61.9   0.0    8.8e-17   61.2   0.0    1.4  1  Ras       Ras family
    1.4e-11   44.7   0.0    3.4e-11   43.4   0.0    1.6  1  Roc       Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.2   0.0   9.8e-21   8.8e-17       3     106 ..     151     259 ..     149     319 .. 0.80

  Alignments for each domain:
  == domain 1  score: 61.2 bits;  conditional E-value: 9.8e-21
                 EEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGGGHHHHHHHHT....TESEEEEEEETTBHHHHHTHHHHHHH CS
         Ras   3 vlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievd.gkevkleiwDTAGqeefkslrelyyr....daegillvyditsresfenvkkwvee 96 
                  ++Gd+++GKt++ +    +k k++y    g+df++k++++  + +++ +i+DTAGqe+f + + ++ r    d +g+ll++++ +  sfe++++w++ 
  EFC37145.1 151 FVLGDTGIGKTTFRYFICYGKKKDSYYGATGIDFLIKRFQIAdEMKCEHKIFDTAGQERFFAPNMMVKRharnDRMGFLLCFSMVHLVSFEKLDEWFSA 249
                 589*************9**********************9974789**************7655444441111668*********************** PP

                 HHHHSTTTSE CS
         Ras  97 ikrvaeenvp 106
                 +k++a+ +++
  EFC37145.1 250 VKEHAHPEIS 259
                 ****994443 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.4   0.0   3.8e-15   3.4e-11       4     108 ..     152     256 ..     150     269 .. 0.79

  Alignments for each domain:
  == domain 1  score: 43.4 bits;  conditional E-value: 3.8e-15
                 EESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTT....T-HHHHCTSCEEEEEEE...GHHHHCH CS
         Roc   4 lvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrs....lhplylreaalailvyd...srssenl 95 
                 ++Gd+g+GKt++   ++ +k ++++   +g+dfl k++ +i      +++ k++ +i+DtaGqerf +    ++++  +++  ++l++      s+e+l
  EFC37145.1 152 VLGDTGIGKTTFRYFICYGKKKDSYYGATGIDFLIKRF-QIA-----DEM-KCEHKIFDTAGQERFFApnmmVKRHARNDRMGFLLCFSmvhLVSFEKL 243
                 79********************************9998.343.....233.5899***********974442334445567778888875434589*** PP

                 HHHHHHHHHHCSS CS
         Roc  96 keWlkelkkvagk 108
                 +eW++ +k++a+ 
  EFC37145.1 244 DEWFSAVKEHAHP 256
                 *********9874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       565  (0.0315132); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 2032.71
//
Query:       EFC37146.1  [L=512]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.8e-15   54.8   0.1    2.3e-14   53.5   0.1    1.7  1  DUF4476   Domain of unknown function (DUF4476)


Domain annotation for each model (and alignments):
>> DUF4476  Domain of unknown function (DUF4476)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.5   0.1   1.3e-18   2.3e-14       2      91 .]     420     510 ..     419     510 .. 0.94

  Alignments for each domain:
  == domain 1  score: 53.5 bits;  conditional E-value: 1.3e-18
     DUF4476   2 msdksfeqlveklkkasfdddklklleqalankaftcsqvvqllk.lfsfdddrlkalkllapnivDk.qnsetiidsftfssdkkkareil 91 
                 +++++++q+++ l++ ++++d + ll+++la  ++tcs v++ +  +f+f ++ ++ + +lap+i+D+ qn+e+i+++f+   d kk+re+l
  EFC37146.1 420 CESHHLKQILKLLTHGPHQRDAISLLSKNLAIGYLTCSSVATDIVpCFDFFSHTFESITTLAPQITDRrQNAEVICKCFND-IDAKKVRELL 510
                 88999***********************************987777**********************6677*******97.999***9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (512 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       729  (0.0406604); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.46
# Mc/sec: 3317.32
//
Query:       EFC37147.1  [L=307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.4e-07   29.5   9.1    1.9e-06   27.0   9.9    1.7  2  MFS_1      Major Facilitator Superfamily


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.1   1.9    0.0042        75     203     282 ..      80     164 ..      31     188 .. 0.61
   2 !   27.0   9.9   1.1e-10   1.9e-06      30     179 ..     121     294 ..      86     307 .] 0.78

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.0042
       MFS_1 203 llkdpvlwillialllfffgfsg........lltllplylqevlglsglllaglllallalvgail..allagrlsdrlgrrrrlllall 282
                 +l++p    ll+++l+ ++g  +        l++ +p      lgls  + +gl+ ++l+++++ +  a+++ r++ ++++ +   ++l+
  EFC37147.1  80 MLSSPI--PLLTCFLYLMLGSKQilfdeclpLFSVTPKE-LGGLGLS-SYHLGLTGGFLGFIIF-MnqAFITPRVIAKFSPLICYRVSLV 164
                 333332..2666666666666668867776666666665.6777777.4555555555555543.3367799999999888555544443 PP

  == domain 2  score: 27.0 bits;  conditional E-value: 1.1e-10
       MFS_1  30 spseigllltlyalgaavas...lplGrlsdrfGrrrvlllglllfalglllll....f..a..ss.......lw.lllvlrvlqGlgagalfpagaal 109
                   s+++l lt+ +lg+++++   +++ r++ +f++  ++ ++l++ +++  +++    +  +  +        +w ++++  +l  +  g +f + + +
  EFC37147.1 121 GLSSYHLGLTGGFLGFIIFMnqaFITPRVIAKFSPLICYRVSLVVDIAF-NVIFpeviWlmVseHDpiwrhvlFWfVFVFILLLRQVSNGYSFLGTLLI 218
                 4566777777877777777433377799999999999999999999999.444436543332442277778888889999999**************** PP

       MFS_1 110 iadwfpkeergraigllsagfslGailgpllggllasslg........Wravfyilaivsllafvlfllllpeepper 179
                 +   +++++ g+ +g  ++ +sl+ ++ p++gg++ +s           r vfy+++i+s+++f l   l++ +  ++
  EFC37147.1 219 TNNSVTRKNSGKLNGTSQSLVSLSRMISPIVGGAIFASSTavskfpidHRTVFYVVGIISVIMFFL--SLILKKSINK 294
                 ***********************************966667**********************775..5553333222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       986  (0.0549947); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 2107.59
//
Query:       EFC37148.1  [L=308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.11   12.1   0.1       0.17   11.6   0.1    1.3  1  Cucumo_coat  Cucumovirus coat protein


Domain annotation for each model (and alignments):
>> Cucumo_coat  Cucumovirus coat protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   9.3e-06      0.17      34     104 ..      76     146 ..      54     175 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.3e-06
                  EEE----B-TT-EEEE----HHHHTTTTSBEEEEEEEEEE-TT--.SEEEEEEEE-CTTTS-SSSHHHHH.S CS
  Cucumo_coat  34 ialkqakldinsknkrlllPdsvvelekklvsriqvivntltksdleqlWltvkklPkvsdllveaisam.d 104
                  i+l+  +        +++l +   + e kl     v+++ + + + e+lW t k l k s+  + +++++ +
   EFC37148.1  76 ITLNVKECSDLEETVKFILEKQERNPEEKLNIMFEVMMQDIRELK-EKLWFTDKDLNKFSEKYISNWNSLtN 146
                  55555666666667899999************************9.**********************9843 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1078  (0.0601261); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2095.55
//
Query:       EFC37149.1  [L=270]
Description: hypothetical protein NAEGRDRAFT_60993 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.7e-39  133.6   0.3    1.5e-19   69.9   0.0    3.1  3  Actin       Actin
  ------ inclusion threshold ------
      0.072   13.6   0.0       0.45   11.0   0.0    2.2  3  EF-hand_12  EF-hand fold domain


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.9   0.0   1.7e-23   1.5e-19       4      89 ..      14     111 ..      11     117 .. 0.92
   2 !   23.2   0.0   2.6e-09   2.4e-05     128     171 ..     117     160 ..     108     161 .. 0.91
   3 !   40.9   0.0   1.1e-14   9.9e-11     258     332 ..     158     222 ..     156     228 .. 0.93

  Alignments for each domain:
  == domain 1  score: 69.9 bits;  conditional E-value: 1.7e-23
       Actin   4 vsavVlDnGssttraGyagedaPkavipslvgkprgrkvea............klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelk 89 
                  ++vV+DnGs+++++G++  d+P+a++p++vg++++++ ++              +vg+ a+++r+ l ++sp+e+G++ + d++e++ +h + e l+
  EFC37149.1  14 RPVVVIDNGSGMIKVGFSCSDSPRAIFPTIVGHKKESSDQKkettnndlnsigSSFVGEMAIAHRELLDIKSPMENGIISNFDDMEKICYHLYPEFLS 111
                 679*****************************999998777899*********************************************999877665 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 2.6e-09
       Actin 128 laksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairr 171
                 + ++ v+ + +s++s g+v+D G++++ +vp+l+G++L +ai+r
  EFC37149.1 117 IQSQSVMGLCSSARSDGVVLDAGYTKSYAVPILEGIALPHAIQR 160
                 5678999999********************************97 PP

  == domain 3  score: 40.9 bits;  conditional E-value: 1.1e-14
       Actin 258 peksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleeekskllgiselivaainacdvdlrpeLlanivvtG 332
                 +++ +eL Dgs++++gee  ++pE+LF+p+li++  +         gi++++v++i ++++++ ++L+aniv++G
  EFC37149.1 158 IQRRFELSDGSKVNFGEELMSCPEALFNPQLIKE-GE---------GIHKILVNSIFNSNAEITRQLFANIVLVG 222
                 7899*************************98776.56.........9***************************9 PP

>> EF-hand_12  EF-hand fold domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       1.7   1.5e+04      45      66 ..      50      71 ..      45      80 .. 0.54
   2 ?   -1.0   0.0      0.28   2.5e+03      17      45 ..      94     122 ..      91     126 .. 0.84
   3 ?   11.0   0.0     5e-05      0.45      11      43 ..     197     229 ..     188     250 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.7
  EF-hand_12 45 pikpkrklssfefeyiqkkffg 66
                + + k++  + +++ i ++f g
  EFC37149.1 50 SSDQKKETTNNDLNSIGSSFVG 71
                4444555555555555555554 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.28
  EF-hand_12  17 afedkeeipWelfanilhkhllkatkqdp 45 
                  f+d e i ++l+   l ++ ++  +q++
  EFC37149.1  94 NFDDMEKICYHLYPEFLSQNQVRIQSQSV 122
                 69999999999999999999888888875 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 5e-05
  EF-hand_12  11 kLlkkeafedkeeipWelfanilhkhllkatkq 43 
                 k+l++ +f++++ei+ +lfani+   ++   + 
  EFC37149.1 197 KILVNSIFNSNAEITRQLFANIVLVGVFPIIEL 229
                 799*******************98877766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       291  (0.0162307); expected 358.6 (0.02)
Passed bias filter:                      271  (0.0151152); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1701.49
//
Query:       EFC37150.1  [L=448]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.2    9.2   4.8        2.8    8.1   0.3    3.1  3  Vps51     Vps51/Vps67


Domain annotation for each model (and alignments):
>> Vps51  Vps51/Vps67
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0      0.59   1.1e+04       9      19 ..      11      21 ..       5      39 .. 0.65
   2 ?    8.1   0.3   0.00016       2.8      56      86 ..     156     186 ..     146     187 .. 0.84
   3 ?    1.7   0.1     0.015   2.7e+02      39      53 ..     345     359 ..     337     386 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.59
       Vps51  9 eayvrellaks 19
                ++++++ll+++
  EFC37150.1 11 NEFFNDLLESN 21
                56777777765 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00016
       Vps51  56 asdtIrkmksemdkldqklselkqaiskiae 86 
                   d+I+km+++  kl ++++ lk++ + i++
  EFC37150.1 156 FVDEIVKMENSNIKLTTQMKRLKSRTRFIEM 186
                 579*********************9988776 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.015
       Vps51  39 dselkalVydnYskL 53 
                 +++l +l+y++Y+ L
  EFC37150.1 345 KNTLSQLIYQSYRAL 359
                 577889999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (448 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1028  (0.0573373); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 2835.98
//
Query:       EFC37151.1  [L=1060]
Description: adenylate cyclase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.7e-19   69.5   0.0    9.2e-19   67.8   0.0    1.9  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    7.2e-13   48.7   0.3    1.6e-12   47.6   0.1    1.7  2  OpuAC          Substrate binding domain of ABC-type glycine b


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.8   0.0     1e-22   9.2e-19       2     158 ..     721     887 ..     720     909 .. 0.78
   2 ?   -2.7   0.0      0.42   3.8e+03      39      60 ..     970     991 ..     968    1000 .. 0.86

  Alignments for each domain:
  == domain 1  score: 67.8 bits;  conditional E-value: 1e-22
  Guanylate_cyc   2 eaesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.........eekaahaaklaelaLdmlea 88 
                    +a+++ + t++F+dI+++t l++    + + ++L  ++  +++ ++++k+y+ kt Gd++ v++  p                    +  L + + 
     EFC37151.1 721 YAPRTTPFTLVFTDIQNSTLLWATA-SETMKSVLSIHNIIMRSNIQKYKGYEAKTAGDSFTVAFVDPlcalafcisV----------QKDLLLANW 805
                    57889999***************88.99***************************************5555555432..........222322222 PP

  Guanylate_cyc  89 l.eevavesk...........eglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkee 158
                      ++    +            +g ++r Gih G+ +   i +k+ r+ + Gn v +A+++e+ +++g+i vs + ++  k+ 
     EFC37151.1 806 PsDSLLLPDMkevrwnesliyRGPRIRMGIHAGSDCNIQIDKKTQRMEYVGNMVHIANKIEASSVGGRIYVSGAFVQAIKSR 887
                    22222222212344444455599**********97777777*******************************9998888744 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.42
  Guanylate_cyc  39 yarfdelldekkvykvktiGda 60 
                    +++f+++l+e  v++ k+iG +
     EFC37151.1 970 IQQFERVLEESPVEEQKVIGQK 991
                    68999**************986 PP

>> OpuAC  Substrate binding domain of ABC-type glycine betaine transport system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.6   0.1   1.8e-16   1.6e-12       3     256 ..     383     661 ..     381     662 .. 0.82
   2 ?   -2.2   0.0      0.28   2.5e+03      69     113 ..     901     946 ..     853     953 .. 0.77

  Alignments for each domain:
  == domain 1  score: 47.6 bits;  conditional E-value: 1.8e-16
                 EEEEEESSHHHHHHHHHHHHHHHHT.TEEEEEEEEESHHHHHHHHHTT..SSSEEEEEEHHHHHHHHHHHHHHHHEEEEEEEESEEECEEEEEEHHHHH CS
       OpuAC   3 ivigsknwteqevlaeilkqllekk.GykveltnlgstavlfaalasG..diDvypeewtgtayeaykkaveekkglevlgplgagnteglavpkyvae 98 
                 +++ + nw   +v a+++k +le++ G+ +e ++++ t +l +  + G     +++e w+ + + +y k+v ++k++  +g+lg +++ g+++   + +
  EFC37151.1 383 LQLIQFNWLGPTVNANVAKIVLEEMlGICAEIVTMNVTHALEEMAEYGtrRSYAMLEFWSESRKFQYDKYVVNDKTIMDVGELGINAKLGWYILGFMKD 481
                 678899*******************************88877777777224567789************99999988889*****************99 PP

                 HHTT.TBHHHHCTHHG.....GTEEEEEHHCCHSTTSHHCCHHHHHHHHHHT-T.TCEEE.GSCEEEEHH.HHHHHHHTTCSSEEEEETTSTHHHHTTE CS
       OpuAC  99 kygi.ksisDLkkpae.....dlelgakgeflgrpdgwgcekvtegllkaYgld.kvelv.egseaamda.elyaaykrgepvvvyawtPdwaikkydl 188
                 +y++ +   +    +      + ++   g+f+g++  w    + ++ +   +l+ +++   e ++++ +  ++++a +r+epv++y+w P+ ++kk+ +
  EFC37151.1 482 EYDLiDEYREYRTEKAahylaTNDTYPLGRFIGGAKSWI--TFDQQIITNLKLNlQIQYTqEENAEDFLIsKIQEANDRKEPVLFYLWYPHQIFKKLSI 578
                 9654388888855555777775578899***********..666777777766444444445555555555**************************77 PP

                 EE-B................-TTSTS-SSEEEEEEEEHHHHHHSCTHHHHHHHHC--HHHHHHHHHHHHTTTT-HHHHHHHHHH CS
       OpuAC 189 vvLe................dpkglfppaynvvpvvrkefaekaPevaafLeklsldtetlnelnaqvdvegkdpeevAkawla 256
                 + +                    +++ p++ +  +v+ ++ e+   + +f++k++    +  +  a++  ++++  ++  +wl+
  EFC37151.1 579 KNVYlppssescwtsynqenQLIDCDYPTELLRKLVSPKLTEDM-VLNSFFSKFAYESTDQIDILADIVFQEMSVVDASCKWLR 661
                 66666699999999997666556666666888888888888888.799999999999999999999999899999999999986 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.28
                 HHHHHHEEEEEEEESEEECEEEEEEHHHHHH.HTTTBHHHHCTHHG CS
       OpuAC  69 aveekkglevlgplgagnteglavpkyvaek.ygiksisDLkkpae 113
                 + +++++ + ++++++++     ++kyv+e  +++  ++DL  ++e
  EFC37151.1 901 KTSKEDVTTSANTQYYDDSSDKGISKYVQELnNNLIEFEDLGPKQE 946
                 5555666666678999999999999***999899999999954443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1060 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2156  (0.120252); expected 358.6 (0.02)
Passed bias filter:                      579  (0.032294); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.89u 0.32s 00:00:01.21 Elapsed: 00:00:00.47
# Mc/sec: 6742.17
//
Query:       EFC37152.1  [L=140]
Description: histone H3 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-48  164.6   3.0    1.5e-48  164.5   3.0    1.0  1  Histone        Core histone H2A/H2B/H3/H4
    0.00012   22.4   0.1    0.00018   21.9   0.1    1.3  1  CENP-S         CENP-S protein
    0.00018   21.6   0.2    0.00018   21.6   0.2    1.6  2  CENP-T_C       Centromere kinetochore component CENP-T histon
    0.00084   19.9   0.4    0.00096   19.8   0.4    1.2  1  PAF            PCNA-associated factor histone like domain
     0.0088   16.3   0.7      0.013   15.8   0.1    1.6  2  CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) a
  ------ inclusion threshold ------
      0.037   14.1   0.4       0.07   13.2   0.2    1.5  2  TFIID-31kDa    Transcription initiation factor IID, 31kD subu


Domain annotation for each model (and alignments):
>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  164.5   3.0   5.1e-52   1.5e-48       1     131 []       1     134 [.       1     134 [. 0.98

  Alignments for each domain:
  == domain 1  score: 164.5 bits;  conditional E-value: 5.1e-52
                 XXEESXEEEXXXXEEXXXXXXXXXXHT...TS-SSSSB--TTT-XTTHHHHHHHHHHHHXXSXXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHH CS
     Histone   1 marekekarkesektapekkvsakker...kasskskkkkkrryrpgtvalkeirkyqkstdlliqklpfaRvvreivksekedlrisaeavlalqeal 96 
                 mar+k++a++  +++ap+k +++k ++   k++++   kk +ry+pgtval+eirkyqkst+lli+klpf+R+vrei ++ k+dlr+++ avlalqea+
  EFC37152.1   1 MARTKQTAYRGVGQKAPRKSIANKIAKksaKQPHSGGLKKVHRYKPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDYKSDLRFQSNAVLALQEAS 99 
                 9**********************9888889999****************************************************************** PP

                 HHHHHHHHHHHHHHHHHTTXSEEXHHHHHHHHHHT CS
     Histone  97 EallvelfeeAnllakhaKRvTitpkDiqlArrlr 131
                 Ea+lv+lfe++nl+a+haKRvTi+ kD+qlA+r+r
  EFC37152.1 100 EAYLVSLFEDTNLCAIHAKRVTIMHKDMQLAARIR 134
                 *********************************97 PP

>> CENP-S  CENP-S protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.1   5.9e-08   0.00018      14      71 ..      73     132 ..      67     138 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 5.9e-08
      CENP-S  14 iveeeaa..ekeveatkqfiaaltelvykqlenlakDLeaFakHAkRstittdDvlLlaR 71 
                 +v+e+a+  ++++++ ++++ al e   + l +l +D ++ a HAkR ti  +D+ L aR
  EFC37152.1  73 LVREIAQdyKSDLRFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMHKDMQLAAR 132
                 455544323667789999*****************************************9 PP

>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       2.7     8e+03      16      23 ..      21      28 ..      14      41 .. 0.56
   2 !   21.6   0.2   5.9e-08   0.00018      14      73 ..      71     130 ..      52     139 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.7
    CENP-T_C 16 lakrfaka 23
                +a+++ak+
  EFC37152.1 21 IANKIAKK 28
                33333333 PP

  == domain 2  score: 21.6 bits;  conditional E-value: 5.9e-08
    CENP-T_C  14 kklakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilL 73 
                 ++l++++a+   s  + + +a+ al++as+ ++  + eD +  a Ha+R ti ++D+ l 
  EFC37152.1  71 QRLVREIAQDYKSDLRFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMHKDMQLA 130
                 678888888888999*****************************************9875 PP

>> PAF  PCNA-associated factor histone like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.4   3.2e-07   0.00096       1      62 [.       1      60 [.       1      92 [. 0.85

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 3.2e-07
         PAF  1 mVRTkAdvssarkavaakAprkslgasssssssssssp..kkkkkkyvGGNpvcpRptPaWQKp 62
                m RTk ++   ++ v+ kAprks++++  ++s++  ++   kk + y +G  v  R++ + QK 
  EFC37152.1  1 MARTKQTA---YRGVGQKAPRKSIANKIAKKSAKQPHSggLKKVHRYKPG-TVALREIRKYQKS 60
                99******...7**************999999887777544555556666.7889999999996 PP

>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       2.4   7.2e+03      38      40 ..      23      25 ..      14      33 .. 0.53
   2 !   15.8   0.1   4.3e-06     0.013       2      64 ..      67     130 ..      66     131 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.4
                   HHH CS
  CBFD_NFYB_HMF 38 eel 40
                   +++
     EFC37152.1 23 NKI 25
                   222 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 4.3e-06
                    XXXHHHHHHHHHCC.TTXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHH CS
  CBFD_NFYB_HMF   2 eLPiarvkkImksd.pdarkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklA 64 
                    +LP  r  + + +d +++ ++ + A   ++e+ e ++ +l + ++  + ++kr ti++++++lA
     EFC37152.1  67 KLPFQRLVREIAQDyKSDLRFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMHKDMQLA 130
                    78888887777777799********************************************998 PP

>> TFIID-31kDa  Transcription initiation factor IID, 31kD subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.8   5.4e+03      64      78 ..      18      32 ..       5      46 .. 0.57
   2 ?   13.2   0.2   2.3e-05      0.07      22      70 ..      86     134 ..      70     139 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.8
  TFIID-31kDa 64 rlAiqsrlekqfkep 78
                 r +i+++++k+  ++
   EFC37152.1 18 RKSIANKIAKKSAKQ 32
                 333444444433333 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 2.3e-05
  TFIID-31kDa  22 eyeerVvlqLldfayrytssvLedAkvlaehakkkevslddvrlAiqsr 70 
                   ++++ vl L +    y +s++ed +++a hak+ ++  +d++lA   r
   EFC37152.1  86 RFQSNAVLALQEASEAYLVSLFEDTNLCAIHAKRVTIMHKDMQLAARIR 134
                  578899999************************************7766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (140 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       468  (0.026103); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 935.79
//
Query:       EFC37153.1  [L=486]
Description: cation efflux protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.8e-50  170.1   1.1    7.1e-50  169.5   1.1    1.3  1  Cation_efflux   Cation efflux family
    0.00055   19.6   6.4     0.0095   15.6   0.0    2.4  2  FAM176          FAM176 family
     0.0029   17.8   0.0        2.7    8.2   0.0    2.2  2  DUF5308         Family of unknown function (DUF5308)
     0.0031   17.9   9.2      0.043   14.2   1.0    2.4  2  PBP1_TM         Transmembrane domain of transglycosylase PBP1
     0.0032   17.2   3.2      0.045   13.5   0.1    2.6  2  Connexin        Connexin
  ------ inclusion threshold ------
      0.013   13.5   0.0      0.013   13.5   0.0    2.2  2  V_ATPase_I      V-type ATPase 116kDa subunit family
      0.015   15.0   0.6       0.27   10.8   0.0    2.3  2  DUF2370         Protein of unknown function (DUF2370)
        0.1   13.6   7.2       0.19   12.7   0.1    3.2  2  DUF4834         Domain of unknown function (DUF4834)
       0.54    9.4  41.7      0.059   12.6  17.1    2.8  2  Zip             ZIP Zinc transporter
        3.8    7.5   5.7         15    5.5   0.4    2.3  2  Neur_chan_memb  Neurotransmitter-gated ion-channel transmembr


Domain annotation for each model (and alignments):
>> Cation_efflux  Cation efflux family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.5   1.1     4e-53   7.1e-50       2     199 .]     106     364 ..     105     364 .. 0.97

  Alignments for each domain:
  == domain 1  score: 169.5 bits;  conditional E-value: 4e-53
  Cation_efflux   2 ilsllanlilalvelivglltnSlalladafhslsdlvsllllllalklsrkppderfpfGygrlevlgalvsgllllglavfllleaiqklikeg 97 
                    ++++ ++l+++l+el+vg++++Sl+llad+fh+lsd +sl+++   ++l++k p++ ++fG+gr+e+lg+l+++++l+ +++++++e+iq+++  +
     EFC37153.1 106 VIMITMVLLMFLAELTVGVMAESLTLLADSFHMLSDGISLMVGAACIWLAKKGPTNLMTFGFGRAETLGGLINAVFLVSVVLYVIMESIQRFF-MP 200
                    799******************************************************************************************.9* PP

  Cation_efflux  98 ereihaglalvvalvslvvnlalllilrragrkl.....................................................rsaalkaaa 140
                    er  ++ l+l+v++++l++nl++l  + ++  +                                                      rs+++ +++
     EFC37153.1 201 ERITDPLLVLCVGGAGLLINLIGLVMFCGHHPHPghdhdhdhghghshkhsheehdhdhehehnhdhdhshhehehtekkehkehkhRSENIFGVF 296
                    **********************99999877544499************************************************************ PP

  Cation_efflux 141 lhvlgDaltslgvlvsalvillfnlksg.........plaDpvaslligliilysalkllkeslseLl 199
                    lh+lgD l+s++v++s+ + l+f+ k            ++Dpv+sl+++ iil++a +llk++ + Ll
     EFC37153.1 297 LHILGDFLGSIAVMISSGLLLIFDKKDEngnyphtwvLYVDPVLSLIMSGIILVTAIPLLKSTCRTLL 364
                    ***********************999879*****9999*************************99997 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   3.9     0.021        38      53      87 ..      27      60 ..      14      84 .. 0.48
   2 !   15.6   0.0   5.3e-06    0.0095      31      96 ..     214     278 ..     199     294 .. 0.54

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.021
      FAM176 53 rlkkkkkklkeesekasededeeeeeeeedssese 87
                +++k+k++++++  ++++d++  +++e+++s++++
  EFC37153.1 27 KEHKHKHHHHDH-GDHHHDHEHHHDDEDDNSTDQT 60
                222222222222.2223333333333333333333 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 5.3e-06
      FAM176  31 cvGLlltLcllviriscrkdlerlkkkkkklkeesekasededeeeeeeeedsseseaeeelsefe 96 
                   GLl+ L+ lv+    +++  +++ +++ + +++++++e++d ++e+e++++++++ +e  +++e
  EFC37153.1 214 GAGLLINLIGLVMFCGHHPHPGHDHDHDHGHGHSHKHSHEEHDHDHEHEHNHDHDHSHHE-HEHTE 278
                 469*********998888877766666555555554444444444443333333332222.21111 PP

>> DUF5308  Family of unknown function (DUF5308)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.1    0.0018       3.2      75     116 ..      16      57 ..       3     151 .. 0.64
   2 !    8.2   0.0    0.0015       2.7      83     118 ..     249     284 ..     177     427 .. 0.63

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0018
     DUF5308  75 aassssspesaasssadssrekktesaeaeeqdqlagaetss 116
                 ++s ss ++++++++++++++++ ++++++e+++ +   +s+
  EFC37153.1  16 KSSASSLNTTTKEHKHKHHHHDHGDHHHDHEHHHDDEDDNST 57 
                 233333333333333333333333333222222222222222 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0015
     DUF5308  83 esaasssadssrekktesaeaeeqdqlagaetssag 118
                 +++++++ +++++++++ ++++++++++++++++++
  EFC37153.1 249 KHSHEEHDHDHEHEHNHDHDHSHHEHEHTEKKEHKE 284
                 111111111111111111111111111111122221 PP

>> PBP1_TM  Transmembrane domain of transglycosylase PBP1 at N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   1.7    0.0027       4.9      23      53 ..      26      59 ..      15      71 .. 0.46
   2 !   14.2   1.0   2.4e-05     0.043      20      76 ..     242     297 ..     234     301 .. 0.60

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0027
     PBP1_TM 23 kkasrrrrrdddydd...eyddeedDdddddeee 53
                 k ++++++  d+ d   + ++++dD+dd+  ++
  EFC37153.1 26 TKEHKHKHHHHDHGDhhhDHEHHHDDEDDNSTDQ 59
                3333334444444442223444444444443333 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 2.4e-05
     PBP1_TM  20 parkkasrrrrrdddyddeyddeedDdddddeeeevprkgkkkkpprkkrrw.lwlli 76 
                 + +++++++++++ d+d e ++++d d+   e+e+  +k +k+   ++++   ++ ++
  EFC37153.1 242 HGHGHSHKHSHEEHDHDHEHEHNHDHDHSHHEHEHTEKKEHKE--HKHRSENiFGVFL 297
                 5566778888999999997666655555666666666664444..4444433265555 PP

>> Connexin  Connexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.4     0.028        50     110     142 ..      28      60 ..       6     122 .. 0.54
   2 !   13.5   0.1   2.5e-05     0.045      87     156 ..     224     296 ..     217     319 .. 0.58

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.028
    Connexin 110 eekeeeekeeekkkkkekkkkkkkeeekekkke 142
                 e+k++++++++ ++++++++++ +e++++++++
  EFC37153.1  28 EHKHKHHHHDHGDHHHDHEHHHDDEDDNSTDQT 60 
                 111111111111111111111111112221111 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 2.5e-05
    Connexin  87 sllylvyvlhkiakeekekek...eeeekeeeekeeekkkkkekkkkkkkeeekekkkeegkrrirggllrtY 156
                  ++++++  h  + + +++ +   +++++ee+++++e++++++++++++++e++ekk+++++++ +++++ ++
  EFC37153.1 224 LVMFCGHHPHPGHDHDHDHGHghsHKHSHEEHDHDHEHEHNHDHDHSHHEHEHTEKKEHKEHKHRSENIFGVF 296
                 5789999998666665533322224444444444444444444444555555555555555555466665544 PP

>> V_ATPase_I  V-type ATPase 116kDa subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   7.6       1.2   2.1e+03     655     692 ..      25      50 ..       2      74 .. 0.35
   2 ?   13.5   0.0   7.1e-06     0.013     637     704 ..     230     298 ..     174     305 .. 0.60

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 1.2
  V_ATPase_I 655 eeeeeeeeeeeeeeaeeeeeeeeeeeeeeeeeeeeeee 692
                 +++e++            ++++++++ ++++++e++++
  EFC37153.1  25 TTKEHK------------HKHHHHDHGDHHHDHEHHHD 50 
                 111111............11111111111111111111 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 7.1e-06
  V_ATPase_I 637 hkkkkkkkekkkeeeee.eeeeeeeeeeeeeeeaeeeeeeeeeeeeeeeeeeeeeeeeeefdfgevfih 704
                 h+ +  + +++++ + + +++++ee+++++e+e++++++++++e+e++e++e++e++++++++  vf+h
  EFC37153.1 230 HHPHPGHDHDHDHGHGHsHKHSHEEHDHDHEHEHNHDHDHSHHEHEHTEKKEHKEHKHRSENIFGVFLH 298
                 443333333332222222444555555555555555666666666666677777777777787777777 PP

>> DUF2370  Protein of unknown function (DUF2370)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.3     0.091   1.6e+02     130     178 ..      25      73 ..      10     119 .. 0.44
   2 ?   10.8   0.0   0.00015      0.27     135     202 ..     237     304 ..     213     312 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.091
     DUF2370 130 saeeskvkkekeegrvepsdpnshdldkekvaekgekeeaaalsdlela 178
                 +++e+k k++++++  + +d ++h+ d++++++ +++  +++ s+l+++
  EFC37153.1  25 TTKEHKHKHHHHDHGDHHHDHEHHHDDEDDNSTDQTQLLKTSSSGLMEY 73 
                 2233333333333333333333333333333333333333333333333 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00015
     DUF2370 135 kvkkekeegrvepsdpnshdldkekvaekgekeeaaalsdlelaeeeknkesssewlayvlmilGlfi 202
                    +++ +g+ +++  ++hd d+e+ +++++++++++++++e++e++++k++s++++ ++l ilG f+
  EFC37153.1 237 DHDHDHGHGHSHKHSHEEHDHDHEHEHNHDHDHSHHEHEHTEKKEHKEHKHRSENIFGVFLHILGDFL 304
                 33444555556666667777777777666666666665555445555566899************987 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   3.9      0.87   1.6e+03      43      77 ..      15      49 ..       4      69 .. 0.46
   2 ?   12.7   0.1   0.00011      0.19      16      85 ..     181     293 ..     102     295 .. 0.66

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.87
     DUF4834 43 qkqfgnstnsnqqksqsrsetkeegeiieeersek 77
                +k++++s n+++++++++++++++g+ ++++++++
  EFC37153.1 15 SKSSASSLNTTTKEHKHKHHHHDHGDHHHDHEHHH 49
                33333333333333333333333333333322222 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 0.00011
     DUF4834  16 viglsilsvilrtv...............................................fglgsrkkssksaqkqfgnstnsnqqksqsrsetkeeg 67 
                 +++ ++l vi++++                                                g g+ +k s ++++++ ++ ++n+++++s++e+++++
  EFC37153.1 181 FLVSVVLYVIMESIqrffmperitdpllvlcvggagllinliglvmfcghhphpghdhdhdHGHGHSHKHS-HEEHDHDHEHEHNHDHDHSHHEHEHTE 278
                 33334444444444555567777777788888888888888777787777777776666665555555544.222222333333333332222222222 PP

     DUF4834  68 eiieeersekeakrkkiF 85 
                   ++e++++k ++  +iF
  EFC37153.1 279 --KKEHKEHK-HRSENIF 293
                 ..22222222.2222666 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5  16.4     0.077   1.4e+02     118     204 ..      10     145 ..       2     166 .. 0.70
   2 ?   12.6  17.1   3.3e-05     0.059      84     198 ..     183     307 ..     163     326 .. 0.50

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.077
         Zip 118 ssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqas............................................. 171
                 s+ + +k+s+s+ +++++e k++h +++++d+ +++e++++ ++ ++      +                                             
  EFC37153.1  10 SASNLSKSSASSLNTTTKEHKHKHHHHDHGDHHHDHEHHHDDEDDNST-----Dqtqllktsssglmeyeldrvklngetlkkiylskskplwkepdfv 103
                 344445566666677777776666666666665555555544444443.....1334568999999999999999999999999999999999888888 PP

         Zip 172 ..........eeedkeklaslkvraiilllglilHsfidGLAl 204
                                 +l+   ++  + ll++++H ++dG++l
  EFC37153.1 104 kmvimitmvlL-MFLAELTVGVMAESLTLLADSFHMLSDGISL 145
                 88888777531.2222333333446788899999999999997 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 3.3e-05
         Zip  84 lGflllllveklltmivek...........................ksshkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeel 155
                 ++ +l+ ++e++ + ++++                            ++      ++  +++ + + +++ +++++ee   +++h++++d+d+++ e++
  EFC37153.1 183 VSVVLYVIMESIQRFFMPEritdpllvlcvggagllinliglvmfcGHH------PHPGHDHDHDHGHGHSHKHSHEEHDHDHEHEHNHDHDHSHHEHE 275
                 5555555555555555555555555555555555555444444432222......22223333333333333333333333333334444444444444 PP

         Zip 156 rngkqeksesekeqaseeedkeklaslkvraiilllglilHsf 198
                 + +k+e++e+++++++              +++ +lg++l s+
  EFC37153.1 276 HTEKKEHKEHKHRSEN-----------IFGVFLHILGDFLGSI 307
                 4444444444444433...........4446666666666555 PP

>> Neur_chan_memb  Neurotransmitter-gated ion-channel transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.4    0.0084        15     127     201 ..      14      88 ..       2     125 .. 0.61
   2 ?    4.1   0.8     0.023        41     130     166 ..     249     285 ..     216     298 .. 0.49

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0084
                     ----------------------------------SS---TTGGG--.....-----TTTTTHHHHHHHHHHHHHH CS
  Neur_chan_memb 127 sseaeelilskskseskkaklseeqgsekastckckckegeeaspstqlskeelspelkkavegvkyiadhlrae 201
                      s++   +l+   +e+k++++++ +g++  + +++  +e+ +++++tql k + s  ++  +++vk   ++l++ 
      EFC37153.1  14 LSKSSASSLNTTTKEHKHKHHHHDHGDHHHDHEHHHDDEDDNSTDQTQLLKTSSSGLMEYELDRVKLNGETLKKI 88 
                     334444444555556777777777777777777777777777777787777777777777777777766666654 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.023
                     -------------------------------SS---T CS
  Neur_chan_memb 130 aeelilskskseskkaklseeqgsekastckckckeg 166
                     + ++  +++++e+++++ ++ +++e ++t+k ++ke+
      EFC37153.1 249 KHSHEEHDHDHEHEHNHDHDHSHHEHEHTEKKEHKEH 285
                     2222222222222222222222222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1802  (0.100508); expected 358.6 (0.02)
Passed bias filter:                      717  (0.0399911); expected 358.6 (0.02)
Passed Vit filter:                       115  (0.00641419); expected 17.9 (0.001)
Passed Fwd filter:                        44  (0.00245412); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.82u 0.34s 00:00:01.15 Elapsed: 00:00:00.51
# Mc/sec: 2858.65
//
Query:       EFC37154.1  [L=518]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   12.7   0.2       0.34   11.3   0.2    1.7  1  TMEM210   TMEM210 family
       0.89    9.5   3.7        2.5    8.1   3.7    1.7  1  Syndecan  Syndecan domain


Domain annotation for each model (and alignments):
>> TMEM210  TMEM210 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.2   3.8e-05      0.34      17      57 ..     468     508 ..     456     514 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3.8e-05
     TMEM210  17 llvvlaGvsascfcalvivavGvlrakgetcprhvdsrlvg 57 
                  +vv  Gv  + ++a++iva+ v r + +t+++ ++ +l++
  EFC37154.1 468 PIVVGGGVMVCAIVAFIIVALVVYRKRRNTTTSDMNVQLMQ 508
                 378888999999********************999998875 PP

>> Syndecan  Syndecan domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   3.7   0.00028       2.5       8      35 ..     466     494 ..     457     498 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00028
    Syndecan   8 vlaaviggvv.vgllfaillvlflvYRmr 35 
                 vl  v+gg+v v  ++a ++v+++vYR r
  EFC37154.1 466 VLPIVVGGGVmVCAIVAFIIVALVVYRKR 494
                 5666777766266778888999*****76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (518 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       966  (0.0538792); expected 358.6 (0.02)
Passed bias filter:                      531  (0.0296168); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.24s 00:00:00.71 Elapsed: 00:00:00.43
# Mc/sec: 3647.28
//
Query:       EFC37155.1  [L=582]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.6e-09   36.6   0.2    1.2e-08   35.2   0.2    1.8  1  RGS            Regulator of G protein signaling domain
  ------ inclusion threshold ------
        1.7    9.2   4.4       0.32   11.6   0.8    1.6  2  TPPII_N        Tripeptidyl peptidase II N terminal


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2   0.2   1.4e-12   1.2e-08       3     114 ..      91     284 ..      89     288 .. 0.93

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 1.4e-12
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.......................................................SHHHHH CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkka.......................................................keqeel 46 
                 e+ ++d   + +F++Fl++ +see+l+F ++ ++++k                                                        +   el
  EFC37155.1  91 EEAIKDVECMDIFKSFLKNCSSEEMLEFIQEYDRYEKVyklkklsyfvsplrrrsitsggsatsgesyhsnvtttascvsnvsdlsvdwnqlkQGVVEL 189
                 66677888899*******************************************************************************999999999 PP

                 HHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS...........................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHH CS
         RGS  47 kkkakeIyneylapsspkelnidkklreelekrleke...........................qpsrklfeeaqeevfellekdsypkFlksel 114
                 k+ a +I++++++++s+ke+ni +  +++le++ e +                            + + lf+ +  ++ + l+ d++p+F++s+ 
  EFC37155.1 190 KESALSIIDTFVSKGSKKEINIGSLQKQSLERFEEINkqiltvdlksttsssqgletllnvldlLNPSILFDGMALAISTDLKFDQFPRFVRSDA 284
                 **********************998888887764444669***********************977888************************85 PP

>> TPPII_N  Tripeptidyl peptidase II N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.8   3.6e-05      0.32      14      91 ..      25     106 ..      10     115 .. 0.72
   2 ?   -3.8   0.1         2   1.8e+04       9      17 ..     159     167 ..     146     185 .. 0.53

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 3.6e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXX----HHHHH....HHHHHHHHHHHTTS- CS
     TPPII_N  14 aaaaaavtanaakpkaaataqaatsv.gspaagdgvatqtdgpaegsgspaspkkgkakaDeYa....EslRDfqcsqiakld 91 
                 +   +a+  n   p  ++++ aat+  +s+   +gv  ++ ++  ++gs++  kk k +a +Y+    E+++D  c  i k  
  EFC37155.1  25 TIQKTASKINCLSPLSPTSP-AATANgSSSFMNEGVDGDSVSSTGSGGSSSKRKKHKFQARDYClvfeEAIKDVECMDIFKSF 106
                 45556677788888888666.555550455566777777777777788888899999******98888999*******99975 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 2
                 XXXXXXXXX CS
     TPPII_N   9 aanataaaa 17 
                  +n t++a+
  EFC37155.1 159 HSNVTTTAS 167
                 233332222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (582 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       670  (0.0373696); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.24s 00:00:00.75 Elapsed: 00:00:00.41
# Mc/sec: 4231.35
//
Query:       EFC37156.1  [L=654]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.1e-43  146.9  18.8    1.3e-42  146.3  18.8    1.2  1  ABC_membrane  ABC transporter transmembrane region
    5.9e-36  124.0   0.0    1.4e-35  122.7   0.0    1.7  1  ABC_tran      ABC transporter
    2.7e-06   27.0   0.2    0.00084   18.8   0.0    2.3  2  SMC_N         RecF/RecN/SMC N terminal domain
    0.00026   21.1   0.1    0.00086   19.5   0.1    1.9  1  DUF87         Helicase HerA, central domain
    0.00077   19.2   0.1     0.0025   17.5   0.1    1.8  1  AAA_29        P-loop containing region of AAA domain
      0.003   16.9   0.0      0.015   14.6   0.0    2.0  2  Zeta_toxin    Zeta toxin
     0.0031   17.8   0.1      0.045   14.0   0.1    2.3  1  AAA_22        AAA domain
     0.0068   16.8   1.3       0.38   11.2   0.3    3.2  2  AAA           ATPase family associated with various cellular 
  ------ inclusion threshold ------
      0.014   14.5   0.0      0.024   13.8   0.0    1.3  1  G-alpha       G-protein alpha subunit
      0.018   15.5   0.1      0.047   14.1   0.1    1.8  1  AAA_16        AAA ATPase domain
      0.018   14.9   0.0      0.041   13.8   0.0    1.5  1  RsgA_GTPase   RsgA GTPase
      0.031   14.0   0.1      0.055   13.2   0.1    1.4  1  AAA_15        AAA ATPase domain
      0.049   12.4   0.7      0.072   11.9   0.1    1.5  2  ABC_ATPase    Predicted ATPase of the ABC class
      0.079   13.0   0.1        1.6    8.7   0.0    2.4  2  AAA_5         AAA domain (dynein-related subfamily)
      0.083   13.1   0.5       0.81   10.0   0.5    2.3  1  SbcCD_C       Putative exonuclease SbcCD, C subunit
       0.12   12.1   0.0        1.1    9.0   0.0    2.2  2  AAA_30        AAA domain
       0.47   10.0   9.1       0.36   10.3   0.5    2.7  3  E1-E2_ATPase  E1-E2 ATPase
        3.7    8.1  14.3        3.5    8.2   0.1    3.5  3  TcpE          TcpE family


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  146.3  18.8   1.3e-45   1.3e-42       6     271 ..      46     312 ..      38     316 .. 0.95

  Alignments for each domain:
  == domain 1  score: 146.3 bits;  conditional E-value: 1.3e-45
                   HHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHSCHHH CS
  ABC_membrane   6 llailagvlsplfplvlgrildtlldkgdpet...ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtnsvGe 99 
                   +  ++ g +  +f++++g +++ ++++ +++t    ++n +++++++++++ +i++++ +++ +++ er+ +r ++ +++++l+q++++fd +++Ge
    EFC37156.1  46 IGWAALGSIPHVFNILMGELIKAVFSSTTAKTsytNEINNLAMWMAIIAVIAAIVMWMGFSMTSYAFERIGVRFKTAYIESLLKQETGYFDMKRTGE 142
                   55556677888999***********98666668899************************************************************* PP

                   HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHT CS
  ABC_membrane 100 llsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgirtVkaf 196
                   l+s +t+ +++++d++++klg ++q+ ++++ g+i+++++ wk++++++a++pli+++++  +  ++ ++++ +k  ++ s++a+E++ +irtV+++
    EFC37156.1 143 LMSWMTESMEQIQDSFSNKLGRIVQFSIQIILGVILALVFAWKMAIAMVAFSPLIAVLMFASGFASQLVTRRTMKISNEGSAMANEVIGAIRTVRSM 239
                   ************************************************************************************************* PP

                   TTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHH CS
  ABC_membrane 197 greeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailf 271
                    +e++++++++ + ++ +  ++ k i+ g  ig++++++  + a+ +w+G+ l ++ge+ +++  +f ++  +l+
    EFC37156.1 240 DAEQKEIDRYKRQMRSGNAMYVIKGIVLGSPIGFSEICIWGILAFGMWWGGKLLQDGEIEFQN--MFRVFTLLLM 312
                   ***************************************************************..8888877665 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  122.7   0.0   1.5e-38   1.4e-35       1     137 []     380     535 ..     380     535 .. 0.96

  Alignments for each domain:
  == domain 1  score: 122.7 bits;  conditional E-value: 1.5e-38
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................... RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.................... 79 
                 lkn ++++k+g+ +a+vG++G+GKSt+++ll + ++p +G+i ldg++l e++ ++lr++ig + qep lf ++ ++en                    
  EFC37156.1 380 LKNFTFNIKPGQSIALVGSSGSGKSTIVSLLERFYEPSSGNIILDGNELAEIDPHWLRSHIGLVGQEPVLFGGT-IKENicyairktsidpfpsdeeii 477
                 79************************************************************************.*****************8888888 PP

                 ..HHHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 ..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  80 ..esdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                   ++ +++++++s+l + +  +t++++++ sLSgGqkqr+a+ara++++p++lllDE+t+
  EFC37156.1 478 naAKAANAHDFISSLPDGY--NTKLGERGVSLSGGQKQRIAIARAVIQNPEILLLDEATS 535
                 7777777999999999888..99***********************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.1    0.0081       8.1      26      41 ..     392     407 ..     375     414 .. 0.72
   2 !   18.8   0.0   8.4e-07   0.00084     136     209 ..     506     575 ..     420     583 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0081
                 EEEEEESTTSSHHHHH CS
                 xxxxxxxxxxxxxxxx RF
       SMC_N  26 ftaivGpNGSGKsnll 41 
                   a+vG+ GSGKs ++
  EFC37156.1 392 SIALVGSSGSGKSTIV 407
                 4589*********998 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 8.4e-07
                 CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreemlekadklv 209
                 +LSgG+k+ +a+a       ++   + llDe  +aLD +  + v + l++  k    ivi++r  ++ ++d ++
  EFC37156.1 506 SLSGGQKQRIAIARA----VIQNPEILLLDEATSALDTNSEAVVQDALNKLMKGRTTIVIAHRLSTIVDSDMIL 575
                 79*****98888744....44555689************************************99998887665 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.1   8.6e-07   0.00086      24      59 ..     391     424 ..     389     577 .. 0.92

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 8.6e-07
       DUF87  24 rHlAilgsTGsGKSntvavLleellekkgatililD 59 
                 +++A +gs+GsGKS+ v+ Lle+ + ++++  +ilD
  EFC37156.1 391 QSIALVGSSGSGKSTIVS-LLERFY-EPSSGNIILD 424
                 579***********9996.78****.*********9 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.1   2.5e-06    0.0025      14      39 ..     382     407 ..     376     411 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 2.5e-06
      AAA_29  14 ghtieidlkgatlltGpsGsGKSTll 39 
                 + t++i++ +++ l+G sGsGKST++
  EFC37156.1 382 NFTFNIKPGQSIALVGSSGSGKSTIV 407
                 56788998889*************98 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   1.5e-05     0.015      18      61 ..     392     435 ..     379     439 .. 0.89
   2 ?   -1.5   0.1       1.3   1.3e+03      69     102 ..     538     571 ..     531     574 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.5e-05
  Zeta_toxin  18 lillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPey 61 
                 +i l+G++G+GKs++ +ll++  e+ ++ + ld+ +l e  P+ 
  EFC37156.1 392 SIALVGSSGSGKSTIVSLLERFYEPSSGNIILDGNELAEIDPHW 435
                 6889********************9999999**99999998885 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.3
  Zeta_toxin  69 pkkaseltqkdaselvekllqeaiengyniiveg 102
                 +++  +++q++  +l++  ++ +i ++ + iv++
  EFC37156.1 538 DTNSEAVVQDALNKLMKGRTTIVIAHRLSTIVDS 571
                 4555667888888888888888888888888887 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.1   4.6e-05     0.045       5     112 ..     390     552 ..     386     569 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 4.6e-05
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaee.................................................erpevv....fvtlpss 50 
                  ++++++G sG+GK+t +  l + ++   +  +                                                            +++++ 
  EFC37156.1 390 GQSIALVGSSGSGKSTIVSLLERFYEP--SSGNiildgnelaeidphwlrshiglvgqepvlfggtikenicyairktsidpF----PsdeeIINAAKA 482
                 6899*******************9953..333356777778777877777777777777777777777777777555544432....033446777777 PP

      AAA_22  51 tsskdllrellralglelkaerlsseell.ealeqalrarav...ielliiDEaqh.lr..s....eealeeL 112
                  +  d+ + l   ++ +l +   +   l   + ++ + arav   +e+l++DEa   l+  s    ++al++L
  EFC37156.1 483 ANAHDFISSLPDGYNTKLGE---RGVSLSgGQKQRIAIARAViqnPEILLLDEATSaLDtnSeavvQDALNKL 552
                 77777777777777777777...55555557777777777777777888888887777665344555555555 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0       0.6   5.9e+02      11      52 ..     120     160 ..     119     174 .. 0.77
   2 !   11.2   0.3   0.00038      0.38      37      98 ..     439     558 ..     393     573 .. 0.61

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.6
                 HHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHH CS
         AAA  11 KTllakavakelgvefleisgsellskyvgesekkirelfke 52 
                 KT+ ++++ k+ ++ ++ ++ +  l +++ es+++i++ f++
  EFC37156.1 120 KTAYIESLLKQ-ETGYFDMKRTGELMSWMTESMEQIQDSFSN 160
                 88888888888.555666666666669**********99976 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00038
                 S.................................................................STTHHHHHHHHHHHHHHHTSTSEEEEEETGGGH CS
         AAA  37 k.................................................................yvgesekkirelfkeakekakpsilfiDEidal 70 
                 +                                                                 +   + +k r  +++a  ++ p il++DE+ + 
  EFC37156.1 439 HiglvgqepvlfggtikenicyairktsidpfpsdeeiinaakaanahdfisslpdgyntklgergVSLSGGQKQRIAIARAVIQN-PEILLLDEATSA 536
                 25555555555555555555555555555555555555555555555666666666666666666655566777888888888887.************ PP

                 HHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  71 aksrsgseseeeervvnqLlteldgvkk 98 
                   ++      +e  v+++L + ++g ++
  EFC37156.1 537 LDTN------SEAVVQDALNKLMKGRTT 558
                 *999......788899999999988876 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   2.4e-05     0.024      25      50 ..     392     417 ..     375     499 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.4e-05
                 EEEEEESTTSSHHHHHHHHHHHCS-- CS
     G-alpha  25 kllllGqseSGKsTilkqlkllykkg 50 
                 ++ l+G+s+SGKsTi+  l+++y+++
  EFC37156.1 392 SIALVGSSGSGKSTIVSLLERFYEPS 417
                 799********************987 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.1   4.7e-05     0.047      25      51 ..     391     417 ..     378     561 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 4.7e-05
      AAA_16  25 elvllsGesGvGKsslvrellralekd 51 
                 +++ l+G sG+GKs++v  l r +e +
  EFC37156.1 391 QSIALVGSSGSGKSTIVSLLERFYEPS 417
                 7899*************9998877776 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   4.1e-05     0.041      90     120 ..     380     411 ..     357     422 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.1e-05
                  HHHHHHHCTT.SEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  90 leelkellkd.ktsvlvGqSGvGKStLinall 120
                  l++ + ++k  + ++lvG+SG GKSt++  l 
   EFC37156.1 380 LKNFTFNIKPgQSIALVGSSGSGKSTIVSLLE 411
                  45555667766999*************99886 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   5.5e-05     0.055      14      50 ..     380     417 ..     376     488 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 5.5e-05
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnk 50 
                 lk+++ ++++     l+G  +sGKS+i+ +l+ F + +
  EFC37156.1 380 LKNFTFNIKPGqSIALVGSSGSGKSTIVSLLERFYEPS 417
                 677777777776789*******************9988 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         3     3e+03     247     265 ..     393     411 ..     386     412 .. 0.77
   2 ?   11.9   0.1   7.2e-05     0.072     299     353 ..     482     537 ..     474     576 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3
                 EEEEE-TTSSHHHHHHHHH CS
  ABC_ATPase 247 tlIvGggfhGKsTLLeAle 265
                 +++vG+   GKsT+++ le
  EFC37156.1 393 IALVGSSGSGKSTIVSLLE 411
                 56899999*****988776 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 7.2e-05
                 EE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS-H CS
  ABC_ATPase 299 gvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsAt 353
                  ++   Fi++LP g +t+        SG   q  +i++a+  + ++lL+DE tsA 
  EFC37156.1 482 AANAHDFISSLPDGYNTKlGERGVSLSGGQKQRIAIARAVIQNPEILLLDEATSAL 537
                 567889************65566678****************************94 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0    0.0017       1.6       3      23 ..     394     414 ..     392     426 .. 0.83
   2 ?    1.4   0.0      0.29   2.9e+02      62      94 ..     521     558 ..     497     578 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0017
                 EEE--SSSSHHHHHHHGGGGB CS
       AAA_5   3 lLvGppGtgKselaerlaaal 23 
                  LvG +G+gKs+++  l +++
  EFC37156.1 394 ALVGSSGSGKSTIVSLLERFY 414
                 69**************99987 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.29
                 ---G-SEEEEESGGG-.....-HHHHHHHHHHHHSSEE CS
       AAA_5  62 aaregeilvlDEvera.....esevlnsLlslleerrl 94 
                  ++++eil+lDE + a     e  v+++L++l+  r+ 
  EFC37156.1 521 VIQNPEILLLDEATSAldtnsEAVVQDALNKLMKGRTT 558
                 345999******98763332235578888888877765 PP

>> SbcCD_C  Putative exonuclease SbcCD, C subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.5   0.00081      0.81      21      88 ..     495     549 ..     484     551 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00081
     SbcCD_C  21 gkekelsrssgtlSGGekqflaylalaaalaalyssaegrepalrlvfLDEAFsklDeesiatllell 88 
                 g +++l ++  +lSGG+kq +   a+a   +a+++       ++++++LDEA s lD +s a + ++l
  EFC37156.1 495 GYNTKLGERGVSLSGGQKQRI---AIA---RAVIQ-------NPEILLLDEATSALDTNSEAVVQDAL 549
                 555566666666777777432...233...22333.......489*************9988877766 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.0    0.0011       1.1      21      50 ..     393     422 ..     385     430 .. 0.86
   2 ?    0.0   0.0       0.6     6e+02      81     112 ..     493     548 ..     472     560 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0011
      AAA_30  21 avltGpAGtGKttalkalreaweaaggrvi 50 
                  +l+G  G+GK+t+++ l++ +e + g++i
  EFC37156.1 393 IALVGSSGSGKSTIVSLLERFYEPSSGNII 422
                 6799******************99866666 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.6
      AAA_30  81 k........................grarlepgtllivDEagmvdtkqlaallkaa 112
                                          +ra +++ ++l+ DEa  +  ++ +a+++ a
  EFC37156.1 493 PdgyntklgergvslsggqkqriaiARAVIQNPEILLLDEATSALDTNSEAVVQDA 548
                 44444555555555555556666666667788899*****9988777777777666 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.5   0.00036      0.36      94     139 ..      62     107 ..      56     124 .. 0.89
   2 ?    4.4   0.9     0.024        24     102     179 ..     149     226 ..     139     228 .. 0.81
   3 ?   -3.9   0.0       8.6   8.6e+03     106     129 ..     540     563 ..     532     569 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00036
                   TTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-ST CS
  E1-E2_ATPase  94 lgkiarlveeakskktplqkkldklgkvlvpvvlliallvfliall 139
                   +g+++++v +++ +kt+ ++++++l+ +++++++++a+++++ + +
    EFC37156.1  62 MGELIKAVFSSTTAKTSYTNEINNLAMWMAIIAVIAAIVMWMGFSM 107
                   789999999******************************9987655 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.024
                   --------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHHHS-TTHHHHHHHHHHHHHHHHH CS
  E1-E2_ATPase 102 eeakskktplqkkldklgkvlvpvvlliallvflialllgkslaeallralallvaaiPcaLplavplalalgarrla 179
                   e+ ++ + ++ +kl +++++ + ++l ++l++++++ +    +a++ l a+ ++ +     L++  ++ +++  +++a
    EFC37156.1 149 ESMEQIQDSFSNKLGRIVQFSIQIILGVILALVFAWKMAIAMVAFSPLIAVLMFASGFASQLVTRRTMKISNEGSAMA 226
                   5556778889999***********************999999988888888888888877777777777777666666 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 8.6
                   ----HHHHHHHHHHHHHHHHHHHH CS
  E1-E2_ATPase 106 skktplqkkldklgkvlvpvvlli 129
                   ++++ +q  l+kl+k  +++v++ 
    EFC37156.1 540 NSEAVVQDALNKLMKGRTTIVIAH 563
                   456677888888888888888775 PP

>> TcpE  TcpE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   2.6     0.053        53      25      68 ..      34     102 ..      14     115 .. 0.65
   2 ?    1.4   1.3      0.47   4.7e+02      30      64 ..     166     205 ..     150     217 .. 0.46
   3 ?    8.2   0.1    0.0035       3.5       2      53 ..     249     304 ..     248     332 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.053
        TcpE  25 slsqiivfvlvlvlllllaslipvikgvl......pfl....................llyivipvvltw 68 
                    ++i++vl ++ +  l+s++ v++ ++      +                      ++++vi++++ w
  EFC37156.1  34 MGWEMIWIVLGMIGWAALGSIPHVFNILMgelikaV-FssttaktsytneinnlamwmAIIAVIAAIVMW 102
                 55689******************9766666654441.034445556666677776665333333333333 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.47
        TcpE  30 ivfvlvlvlllllaslipvikgvl......pflllyivipv 64 
                 + f + ++l ++l  l++++k ++      p ++++++ ++
  EFC37156.1 166 VQFSIQIILGVIL-ALVFAWKMAIamvafsPLIAVLMFASG 205
                 3333333333333.444443333321222333344444444 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0035
        TcpE   2 YtkilkapkkiqkikdfsLpfpislsqiivfvlvlvlllllaslipv....ikgvl 53 
                 Y++ ++    ++ ik + L  pi +s+i +  ++++ +   ++l++     +++++
  EFC37156.1 249 YKRQMRSGNAMYVIKGIVLGSPIGFSEICIWGILAFGMWWGGKLLQDgeieFQNMF 304
                 99**************************9999998888766666665564444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (654 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1275  (0.0711138); expected 358.6 (0.02)
Passed bias filter:                      677  (0.0377601); expected 358.6 (0.02)
Passed Vit filter:                       112  (0.00624686); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              18  [number of targets reported over threshold]
# CPU time: 0.86u 0.41s 00:00:01.27 Elapsed: 00:00:00.55
# Mc/sec: 3557.44
//
Query:       EFC37157.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-08   34.8   0.0    2.1e-08   34.4   0.0    1.2  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.4   0.0   1.2e-12   2.1e-08       3      93 ..       6      98 ..       4     105 .. 0.83

  Alignments for each domain:
  == domain 1  score: 34.4 bits;  conditional E-value: 1.2e-12
                EEEEEEEEESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEE.EEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHT CS
          C2  3 levtvieAknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWn.ekftfevaeleeakLeveVfdndrlskddfiGkveiplstlls 93
                l +t +++++Lp+ d  +s+d+y++v +     +++++kT+ +++  nP W+   f  +v+   ++   ve++d+d+  +++ + ++ ++l +l+s
  EFC37157.1  6 LNLTLHCGRDLPKADLLSSIDAYAVVIVpiigGQTKTFKTKCVQDDPNPDWEfDLFCTDVD--GTRDCLVEIWDEDT-LRNEKVCTAILSLVELKS 98
                8999**********************999**999*******999999****6333444555..588888********.666668888888877555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       396  (0.0220871); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.31s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1092.87
//
Query:       EFC37158.1  [L=214]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.03   14.3   0.2       0.03   14.3   0.2    1.7  2  Cdc6_C     CDC6, C terminal winged helix domain
        0.7    9.9   3.6        1.3    9.0   0.1    2.4  2  Nudix_N_2  Nudix N-terminal


Domain annotation for each model (and alignments):
>> Cdc6_C  CDC6, C terminal winged helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.2   3.4e-06      0.03      18      59 ..      20      64 ..      10      69 .. 0.87
   2 ?   -2.8   0.1       0.7   6.3e+03       9      20 ..      82      93 ..      76      98 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3.4e-06
                HHHHHHHHHHHHHHTT-...----HHHHHHHHHHHHHTTSEEEEE CS
      Cdc6_C 18 tgevyevYkslCesegv...dpltqrevsdllseLemlgilelek 59
                + ++++ Y+++C+++++   d l+  + +++++ L+   i ++ +
  EFC37158.1 20 LEKIHKNYERICDRYNLekkDFLNDVSLYNHCDLLSVSNIYSTIR 64
                679**************77778999**********9999887765 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.7
                CHCSSS-EEHHH CS
      Cdc6_C  9 rksgkeevttge 20
                rk++++++t+ge
  EFC37158.1 82 RKRNQNTTTLGE 93
                356777777776 PP

>> Nudix_N_2  Nudix N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   1.1     0.067     6e+02       3       7 ..     111     115 ..     109     117 .. 0.61
   2 ?    9.0   0.1   0.00015       1.3      14      32 ..     150     168 ..     143     168 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.067
                 -TTT- CS
   Nudix_N_2   3 CsqCG 7  
                 C +CG
  EFC37158.1 111 CAHCG 115
                 66666 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00015
                 --TT-SS-EEEETTTTEEE CS
   Nudix_N_2  14 ipdgDnreRlvCpaCgtih 32 
                 + dgD    +vC  Cg++h
  EFC37158.1 150 LTDGDGVSLHVCVGCGMVH 168
                 568888888*********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1007  (0.056166); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 1393.01
//
Query:       EFC37159.1  [L=1111]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-88  294.3   0.0      3e-32  111.5   0.0    3.4  3  AAA_5            AAA domain (dynein-related subfamily)
    0.00015   21.9   1.2     0.0042   17.2   0.1    3.4  4  AAA_2            AAA domain (Cdc48 subfamily)
    0.00027   21.4   0.6         24    5.2   0.0    4.9  5  AAA_16           AAA ATPase domain
     0.0036   17.7   3.6        1.5    9.3   0.0    4.2  4  AAA              ATPase family associated with various cellul
      0.008   15.9   0.1        6.3    6.6   0.1    2.8  2  AAA_29           P-loop containing region of AAA domain
  ------ inclusion threshold ------
      0.033   14.3   0.1        4.8    7.3   0.0    3.0  2  Sigma54_activ_2  Sigma-54 interaction domain
      0.049   13.4   0.2        8.2    6.1   0.0    3.4  3  IstB_IS21        IstB-like ATP binding protein
        0.1   12.9   2.5         58    4.0   0.0    4.6  4  AAA_22           AAA domain
       0.38   11.1   2.7       0.79   10.0   1.3    2.3  2  DUF2683          Protein of unknown function (DUF2683)


Domain annotation for each model (and alignments):
>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.5   0.0   1.5e-35     3e-32       1     138 []     153     311 ..     153     311 .. 0.99
   2 !   79.9   0.0   8.5e-26   1.7e-22       1     138 []     521     676 ..     521     676 .. 0.96
   3 !   99.2   0.0   9.7e-32   1.9e-28       1     128 [.     845     989 ..     845     999 .. 0.94

  Alignments for each domain:
  == domain 1  score: 111.5 bits;  conditional E-value: 1.5e-35
                 EEEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--.........--------G-SEEEEESGGG--HHHHHHHHHHHHSSEEE..-S CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraaregeilvlDEveraesevlnsLlslleerrllleeg 99 
                 d++L+G  G  K+ la  ++++ +r+veyv +t+dt+e d+k+rrei+ g + +vd+++vraa++g++l+l+++e+a+ ++l++L++l+e+r++ le+g
  EFC37159.1 153 DMFLIGHYGELKRHLAFTYCQLARRSVEYVCITKDTSEHDFKQRREIETGSAFYVDQAAVRAAKNGSVLILEGIEKADLNILPILNNLMENREMALESG 251
                 689************************************************************************************************ PP

                 SSEEE---..........................-EEEEEESS--..-TT-TTHHHHTT- CS
       AAA_5 100 gelvkakndd.ller...................frviatanpld.rslnelspalrsRf 138
                 + l++ ++++ l+e+                   fr+ia + p++ +++n l+p+lrsRf
  EFC37159.1 252 TMLISPQRYKqLIEEegktpeelklmkiepvhedFRIIAMGLPVPyYDGNTLDPPLRSRF 311
                 **********99999********************************************9 PP

  == domain 2  score: 79.9 bits;  conditional E-value: 8.5e-26
                 EEEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--..........--------G-SEEEEESGGG--HHHHHHHHHHHHSSEEE..- CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreik.ngttslvdsplvraaregeilvlDEveraesevlnsLlslleerrlllee 98 
                 d++L+G +G+gKs ++  +a++++ + ++  +++ +t++dl+++r ++  g+t +++s+l +++  g++++lD+++r+++++l s ++l+ +r l+l +
  EFC37159.1 521 DMCLIGGKGSGKSLISHAFASMVGYKAVVFPMYKEMTSKDLLQKRGTDsAGNTIWKNSVLIDSMIDGSLCILDGIDRMSTDILLSIQTLIQDRVLYLFN 619
                 68********************************************99*************************************************** PP

                 SSSEEE---.........................-EEEEEESS--.-TT-TTHHHHTT- CS
       AAA_5  99 ggelvkakndd.ller..................frviatanpldrslnelspalrsRf 138
                 g+++v+++ +d +l++                  fr+ia + + +  l++ls +l  +f
  EFC37159.1 620 GNRYVSHEYYDkFLSQgftkeelsskgiyrihedFRIIAIGLNDS--LKWLSLELFNLF 676
                 ***************************************999877..888888876655 PP

  == domain 3  score: 99.2 bits;  conditional E-value: 9.7e-32
                 EEEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--.........--------G-SEEEEESGGG--HHHHHHHHHHHHSSEEE..-S CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraaregeilvlDEveraesevlnsLlslleerrllleeg 99 
                 + lL+G +G+gK++++++++ +l++e ey+ql+rd+t + l+ + ++ +g   + dsplv+a+r+g+ilvlDE+++a+ ev+++L sl e+  + l +g
  EFC37159.1 845 HSLLIGYQGVGKNKITDQFLNLLQCEREYMQLHRDITIASLTVQPSVVDGVLTYIDSPLVKAVRHGRILVLDEIDKAPLEVVSILKSLVEDGNMVLGDG 943
                 579************************************************************************************************ PP

                 SSEEE---.....................-EEEEEESS--...-TT CS
       AAA_5 100 gelvkakndd.ller..............frviatanpld..rsln 128
                 ++ v  k+++ + ++              fr+ia++np+   + +n
  EFC37159.1 944 RTIVTMKEYQkRKQQndphlhkllpimkgFRIIALSNPPTfpFHGN 989
                 **********88888***********************98665554 PP

>> AAA_2  AAA domain (Cdc48 subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.23   4.5e+02      59     113 ..     208     251 ..     167     256 .. 0.76
   2 ?   -2.0   0.0       1.7   3.5e+03       8      45 ..     524     557 ..     521     597 .. 0.77
   3 ?   -3.5   0.0       4.8   9.5e+03      76     102 ..     689     713 ..     688     737 .. 0.73
   4 !   17.2   0.1   2.1e-06    0.0042       7     118 ..     847     948 ..     845     951 .. 0.72

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.23
                 HTTT-HHHHTTSEEEEETGGG-------------HHHHHHHHHHHH--EE----- CS
       AAA_2  59 appgyvgaeegGivllDEidKihpkessgadvSregVqrdLLqileggtltdkqg 113
                  + +  +a++g ++ l+ i+K+             +++ +L +++e+ ++  ++g
  EFC37159.1 208 DQAAVRAAKNGSVLILEGIEKADL-----------NILPILNNLMENREMALESG 251
                 4445555556669999******99...........77777777777766665555 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.7
                 EE--TTSSHHHHHHHHHHHTT-....-EEEEEGGG--- CS
       AAA_2   8 llgptgvGktelakalaellfvkkekkliradaselle 45 
                 l+g +g+Gk++++ a a++       k +++ + + ++
  EFC37159.1 524 LIGGKGSGKSLISHAFASMVGY----KAVVFPMYKEMT 557
                 6788999*******99999986....666666666555 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 4.8
                 TGGG-------------HHHHHHHHHH CS
       AAA_2  76 EidKihpkessgadvSregVqrdLLqi 102
                 E+d  ++  + gad S+++  ++L +i
  EFC37159.1 689 EVDLLSS--RVGADASSQNLINALIRI 713
                 5555555..788999999999999887 PP

  == domain 4  score: 17.2 bits;  conditional E-value: 2.1e-06
                 EEE--TTSSHHHHHHHHHHHTT-....-EEEEEGGG---..----THHHHHHHHHTTT-HHHHTTSEEEEETGGG-------------HHHHHHHHHHH CS
       AAA_2   7 lllgptgvGktelakalaellfvkkekkliradaselle..eeevehlvsrligappgyvgaeegGivllDEidKihpkessgadvSregVqrdLLqil 103
                 ll+g +gvGk+ ++++  +ll++++e      d +      +  v   v    + +p  +++  g i+ lDEidK+             +V+ +L  ++
  EFC37159.1 847 LLIGYQGVGKNKITDQFLNLLQCEREYMQLHRDITIASLtvQPSVVDGVLTY-IDSPLVKAVRHGRILVLDEIDKAPL-----------EVVSILKSLV 933
                 6789999999999999999999855555555555543331122333333332.3455556666666************...........********** PP

                 H--EE-------EE- CS
       AAA_2 104 eggtltdkqgrkvdt 118
                 e+g++   +gr++ t
  EFC37159.1 934 EDGNMVLGDGRTIVT 948
                 **********99976 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0       0.1   2.1e+02     125     164 ..     209     246 ..     149     255 .. 0.81
   2 ?    2.6   0.0     0.079   1.6e+02      25      49 ..     520     544 ..     501     563 .. 0.71
   3 ?    4.8   0.0     0.017        33      15      49 ..     836     868 ..     825     901 .. 0.77
   4 ?    5.2   0.0     0.012        24     134     164 ..     908     938 ..     894     947 .. 0.81
   5 ?   -3.3   0.0       5.1     1e+04     143     161 ..    1081    1099 ..    1058    1104 .. 0.73

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.1
      AAA_16 125 rllallsrderplvlvlDdlqwadeaslqllaaLlrlles 164
                 +++++++++++  vl+l+ +++ad   l +l +L++++e+
  EFC37159.1 209 QAAVRAAKNGS--VLILEGIEKADLNILPILNNLMENREM 246
                 34445555355..*********************999876 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.079
      AAA_16  25 elvllsGesGvGKsslvrellrale 49 
                   + l+G +G+GKs +  +++  + 
  EFC37159.1 520 KDMCLIGGKGSGKSLISHAFASMVG 544
                 557799********99998885544 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.017
      AAA_16  15 alervrsgrpelvllsGesGvGKsslvrellrale 49 
                 +l++   g+    ll+G++GvGK ++ +++l+ l+
  EFC37159.1 836 MLKDHLIGD--HSLLIGYQGVGKNKITDQFLNLLQ 868
                 555555564..5689**************997544 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.012
      AAA_16 134 erplvlvlDdlqwadeaslqllaaLlrlles 164
                 ++  +lvlD++++a  +  ++l++L++++++
  EFC37159.1 908 RHGRILVLDEIDKAPLEVVSILKSLVEDGNM 938
                 3558*********************998776 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 5.1
      AAA_16  143 dlqwadeaslqllaaLlrl 161 
                  d++ +d ++l++la  ++ 
  EFC37159.1 1081 DFDSFDRETLEFLAKVFQK 1099
                  4888899888888877765 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1      0.45   8.9e+02      66     120 ..     320     368 ..     304     376 .. 0.80
   2 ?   -2.1   0.1       2.4   4.8e+03      80      98 ..     437     455 ..     426     502 .. 0.55
   3 !    9.3   0.0   0.00073       1.5       1      37 [.     522     564 ..     522     603 .. 0.70
   4 ?    5.5   0.0     0.011        22       2      70 ..     847     921 ..     846     975 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.45
                 TGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHHH CS
         AAA  66 EidalaksrsgseseeeervvnqLlteldgvkkkeskvivigatnrpdkldpall 120
                  ++++++s       ++ r+ +q l++l++++kk+  + +i  t+++ +ld+ l+
  EFC37159.1 320 SMESIFSSL------VNHRTNDQVLSFLSNEQKKSLFLSLIQFTQSIVHLDNMLM 368
                 566666666......899999**********998777778999999999999887 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2.4
                 HHHHHHHHHHHHHHHHTTT CS
         AAA  80 eeeervvnqLlteldgvkk 98 
                 e+e+  +n++++ ++++ k
  EFC37159.1 437 EDEKLEQNKMIEIIKEQLK 455
                 5555555555555544333 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00073
                 EEEESSTTSSHHHHHHHHHHHHTHE......EEEEETTTCSSS CS
         AAA   1 vllyGppGtGKTllakavakelgve......fleisgsellsk 37 
                 ++l+G +G GK+l+ +a a+ +g +      + e+  ++ll+k
  EFC37159.1 522 MCLIGGKGSGKSLISHAFASMVGYKavvfpmYKEMTSKDLLQK 564
                 79*******************9855333333566666666655 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.011
                 EEESSTTSSHHHHHHHHHHHHT..HEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTS....TS.EEEEEETGGGH CS
         AAA   2 llyGppGtGKTllakavakelg..vefleisgsellskyvgesekkirelfkeakeka....kp.silfiDEidal 70 
                 ll+G  G+GK  +  +  + l+  +e++++     +   +  +++ + ++++ + +      ++  il++DEid+ 
  EFC37159.1 847 LLIGYQGVGKNKITDQFLNLLQceREYMQLHRDITI-ASLTVQPSVVDGVLTYIDSPLvkavRHgRILVLDEIDKA 921
                 899****************98633556666554444.56667788888888888666666675559********85 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.1    0.0031       6.3      23      41 ..     519     538 ..     509     548 .. 0.77
   2 !    6.0   0.0    0.0049       9.7      24      50 ..     845     871 ..     835     875 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0031
      AAA_29  23 g.atlltGpsGsGKSTllDA 41 
                 g  + l+G  GsGKS +  A
  EFC37159.1 519 GkDMCLIGGKGSGKSLISHA 538
                 445899*********77655 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0049
      AAA_29  24 atlltGpsGsGKSTllDAiqalLvpak 50 
                   ll+G +G+GK  + D +  lL +++
  EFC37159.1 845 HSLLIGYQGVGKNKITDQFLNLLQCER 871
                 68*****************99998876 PP

>> Sigma54_activ_2  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1     0.039        78      12     117 ..     139     266 ..     129     277 .. 0.74
   2 ?    7.3   0.0    0.0024       4.8      25      95 ..     523     612 ..     504     628 .. 0.76

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.039
                      HHHHHHH...T-SS-EEEEEETT--HHHHHHCC--TTS-EE--SSTTHHHH-H.................HHHHHHT.TTSEEEEEE-TT--HH CS
  Sigma54_activ_2  12 erLeqaa...qsklpvfltGekGsgkelvArlLhknsgpwleifvverlaklp.................ldlleqa.kggtLylkdiadlska 84 
                      ++L+ +a   + k  +fl+G  G  k   A + ++ + + +e + + ++ ++                  +  +  a +g +L+l++i++ + +
       EFC37159.1 139 SHLKWMAmkdKMKQDMFLIGHYGELKRHLAFTYCQLARRSVEYVCITKDTSEHdfkqrreietgsafyvdQAAVRAAkNGSVLILEGIEKADLN 232
                      55555554445677899999999999999999999999999998887777655566777777777555554444444467799*********99 PP

                      HHHHHHHHHHHHT.TTT-EEEEEEEE-TTT..-- CS
  Sigma54_activ_2  85 eqkeLlellakae.ksslrlVstsskdleqllea 117
                       +  L +l+++ e   ++    +s ++ +ql+e+
       EFC37159.1 233 ILPILNNLMENREmALESGTMLISPQRYKQLIEE 266
                      9999999999988777777777777888877765 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0024
                      EEEEETT--HHHHHHCC--TTS-EE--SSTTHHHH-HHHHHHH....................TTTSEEEEEE-TT--HHHHHHHHHHHHH CS
  Sigma54_activ_2  25 fltGekGsgkelvArlLhknsgpwleifvverlaklpldlleq....................akggtLylkdiadlskaeqkeLlellak 95 
                       l+G+kGsgk+l++ ++++  g +  +f + +     +dll++                    ++g + +l +i+ +s + +  ++ l++ 
       EFC37159.1 523 CLIGGKGSGKSLISHAFASMVGYKAVVFPM-YKEMTSKDLLQKrgtdsagntiwknsvlidsmIDGSLCILDGIDRMSTDILLSIQTLIQD 612
                      589*******************99999999.555555555555444444444444444333344777778888888888888888888875 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.08   1.6e+02      38      73 ..     138     177 ..     124     232 .. 0.75
   2 ?    6.1   0.0    0.0041       8.2      49      87 ..     521     557 ..     491     602 .. 0.72
   3 ?    0.3   0.0      0.25   4.9e+02      46     122 ..     844     923 ..     822     931 .. 0.57

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.08
   IstB_IS21  38 Latlsfiek....kenivllGpsGvGKshlaialgveavr 73 
                 L  l++++     k+ + l+G+ G  K hla +  + a r
  EFC37159.1 138 LSHLKWMAMkdkmKQDMFLIGHYGELKRHLAFTYCQLARR 177
                 555666644111157899*************887766544 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0041
   IstB_IS21  49 nivllGpsGvGKshlaialgveavraglsvlfvrvedLv 87 
                  ++l+G+ G GKs ++ a++       ++v+f   +++ 
  EFC37159.1 521 DMCLIGGKGSGKSLISHAFASMV--GYKAVVFPMYKEMT 557
                 589***************98643..23345555555554 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.25
   IstB_IS21  46 kkenivllGpsGvGKshlaia.lgveavraglsvlfvrvedLveelkrarrdgklara....lkrllkvdllilDdlgllpl 122
                 ++   +l+G  GvGK  ++   l    +++++  l+  ++    +++    dg l+ +    +k++ + ++l+lD++   pl
  EFC37159.1 844 DH--SLLIGYQGVGKNKITDQfLNLLQCEREYMQLHRDITIASLTVQPSVVDGVLTYIdsplVKAVRHGRILVLDEIDKAPL 923
                 44..478999999999998652566677777776665444444444444444443322111133333347777777766665 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       2.2   4.4e+03      53      96 ..     458     501 ..     427     510 .. 0.51
   2 ?    4.0   0.0     0.029        58       8      58 ..     522     563 ..     519     570 .. 0.84
   3 ?    1.2   0.0      0.21   4.2e+02       8      44 ..     846     884 ..     843     904 .. 0.75
   4 ?    3.3   0.0     0.045        91      90     118 ..     910     935 ..     897     949 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.2
      AAA_22  53 skdllrellralglelkaerlsseellealeqalrarav..ielli 96 
                 s+++ + + +++  ++++  ++++el+  l  +++a++   i++++
  EFC37159.1 458 STKIHEIISQDFS-PASS-SDQKQELIGNLLSQAKATHFkdIGFVL 501
                 3333222223333.3333.577777774444444444433555555 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.029
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdllr 58 
                 ++++G +G+GK++    +++           + + v + + ++++skdll+
  EFC37159.1 522 MCLIGGKGSGKSLISHAFASMV---------GYKAVVFPMYKEMTSKDLLQ 563
                 5799***********9999998.........77777777777777777776 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.21
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaee.erpevv.f 44 
                  +++G  G+GK     ++l+ l+ e +  + +r+ ++ +
  EFC37159.1 846 SLLIGYQGVGKNKITDQFLNLLQCEREYMQlHRDITIaS 884
                 689****************99975544444666666643 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.045
      AAA_22  90 avielliiDEaqhlrseealeeLrsllnl 118
                 +  ++l++DE+++  + e+++ L+sl+++
  EFC37159.1 910 G--RILVLDEIDKA-PLEVVSILKSLVED 935
                 3..59*********.***********984 PP

>> DUF2683  Protein of unknown function (DUF2683)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   1.3    0.0004      0.79      11      70 ..     442     499 ..     438     508 .. 0.90
   2 ?   -3.7   0.0       7.5   1.5e+04      40      66 ..     950     976 ..     946     979 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.0004
     DUF2683  11 esnriieivKakydlkdksaAidllieqyaeyllEaElkPefvekirnimKgeepidigd 70 
                 e+n++iei+K +  lk+ s  i  +i+q  +     + k e + +++   K +++ dig 
  EFC37159.1 442 EQNKMIEIIKEQ--LKECSTKIHEIISQDFSPASSSDQKQELIGNLLSQAKATHFKDIGF 499
                 68*******986..9*************99999999**********************95 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 7.5
     DUF2683  40 aeyllEaElkPefvekirnimKgeepi 66 
                 +ey + +  +  +++k++ imKg + i
  EFC37159.1 950 KEYQKRKQQNDPHLHKLLPIMKGFRII 976
                 566677777777889999999987776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1103  (0.0615204); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.88u 0.36s 00:00:01.24 Elapsed: 00:00:00.51
# Mc/sec: 6566.30
//
Query:       EFC37160.1  [L=787]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.064   13.5   4.3       0.13   12.5   4.3    1.4  1  FliJ      Flagellar FliJ protein
       0.11   13.2   0.0        0.5   11.0   0.0    2.3  1  VWA_2     von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> FliJ  Flagellar FliJ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   4.3   1.5e-05      0.13      29      86 ..     507     562 ..     493     566 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.5e-05
        FliJ  29 qeyqkqlsgeaqglsaaelrnyqafisaldeaiaqqkqelaqaekqvekareewqear 86 
                 q y+k+l++    ++a e+  y+++++++ ++i+q++++la ++ + e+ ++ w++ +
  EFC37160.1 507 QAYKKRLQEID--MTAHEMNLYSQYKNNVSQQIDQLRKTLAGLKWRDEEEERVWIKNQ 562
                 56788888887..999********************************9999999877 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   5.6e-05       0.5       3      38 ..     606     643 ..     604     717 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 5.6e-05
       VWA_2   3 fvlDtSgSmrngdygptrleaakdaveallksl.p.gd 38 
                 fv+D+SgSm + + +  rl+++ +++  +++s+   +d
  EFC37160.1 606 FVMDVSGSMYRFNHQDERLDKMLEIAVIIMESFkGfED 643
                 9********99989999*******99999998842344 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (787 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1060  (0.0591221); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.54
# Mc/sec: 4396.84
//
Query:       EFC37161.1  [L=267]
Description: hypothetical protein NAEGRDRAFT_59834 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.029   13.5   0.3       0.05   12.7   0.3    1.3  1  Glu_synthase  Conserved region in glutamate synthase
       0.19   11.6   0.2       0.26   11.2   0.2    1.2  1  Wzy_C_2       Virulence factor membrane-bound polymerase, C-t


Domain annotation for each model (and alignments):
>> Glu_synthase  Conserved region in glutamate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.3   5.6e-06      0.05      17      94 ..      41     117 ..      31     121 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.6e-06
                   H---HHHHHHHHHHHTS.-S-SGGGGEEE--SS--.--GGGS--HHHHHTTEE---B-TTTS-HHHHHHHHHHHHHHT CS
  Glu_synthase  17 veskesidkyrekleerevlkakrdlleldaaeealikleevepalkikkriltsamSyGalseeahealakamnrlg 94 
                   ++ +  +++y+ ++++++ + a      +d+++++l  ++ v++ + +++  +ts  S+G ls +a++ + +a +++ 
    EFC37161.1  41 SQCTRPFNTYSSSAKRSTAA-AVALSKTFDFSQDILAAQTAVNQESDVSTLAATSLFSFGKLSAKAKQNVKMAPKHFT 117
                   44566777777777766433.33344467789999999*******************************999987765 PP

>> Wzy_C_2  Virulence factor membrane-bound polymerase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.2   2.9e-05      0.26      44     127 ..       6      88 ..       1      95 [. 0.84

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.9e-05
     Wzy_C_2  44 rlrlrpklvlrvvalvlallglalllsilhdyqrleqlyltsepneaalrevtnpkvwkdrflfrayadllelgllplspenla 127
                 + rl+ +  + +++l+la++++ l++ + h ++ ++q  ++ +  + + ++ t++ v+ +   f+  +d l++ ++ ++ +++ 
  EFC37161.1   6 QPRLKERKKMSLFTLLLAICLCGLIYAMPHVNATASQCTRPFNTYSSSAKRSTAAAVALS-KTFDFSQDILAAQTAVNQESDVS 88 
                 455666666788999**************************************9999998.78888899999999888877765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       836  (0.0466284); expected 358.6 (0.02)
Passed bias filter:                      596  (0.0332422); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1624.62
//
Query:       EFC37162.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-12   47.5   0.0    3.2e-12   46.6   0.0    1.5  1  Abhydrolase_1   alpha/beta hydrolase fold
    5.3e-08   33.0   0.1    1.2e-07   31.9   0.1    1.7  1  Ank_5           Ankyrin repeats (many copies)
      1e-07   32.4   0.0    2.2e-07   31.4   0.0    1.6  1  Ank_2           Ankyrin repeats (3 copies)
    1.7e-07   30.8   0.0    2.8e-07   30.0   0.0    1.3  1  Hydrolase_4     Serine aminopeptidase, S33
    3.2e-06   27.9   0.0    4.7e-06   27.4   0.0    1.3  1  Abhydrolase_6   Alpha/beta hydrolase family
    4.3e-05   23.8   0.1    0.00015   22.0   0.1    2.0  2  Ank             Ankyrin repeat
    0.00024   21.6   0.1     0.0034   17.9   0.0    2.4  2  Ank_4           Ankyrin repeats (many copies)
     0.0064   16.9   0.1      0.035   14.6   0.0    2.4  2  Ank_3           Ankyrin repeat
  ------ inclusion threshold ------
       0.12   11.6   0.0       0.23   10.8   0.0    1.3  1  Glyco_transf_9  Glycosyltransferase family 9 (heptosyltransfe


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.6   0.0   1.6e-15   3.2e-12       3     125 ..     313     429 ..     311     465 .. 0.86

  Alignments for each domain:
  == domain 1  score: 46.6 bits;  conditional E-value: 1.6e-15
                    EEEE-STTT..CGGGGTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB.CHHSHHHHHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHHHGG CS
  Abhydrolase_1   3 lvilhGlpg..ssdvwaerglapaLakdgfdvillDlrGvgySspapacinddygtasvaddldrildalgddkltlvGhSmGGmialayaaeype 96 
                    ++++hG+    s++ w++  la aL ++g+dvillDl+G+g+Ss a  +  ++    +  d+++ il+ l + ++ ++G + G ++ +  + +yp+
     EFC37162.1 313 VICCHGFSYcqSGYQWIK--LAAALHQRGWDVILLDLPGFGKSSGATHQ--TRIWKNDGPDIVKTILEGLSLPRICVIGRCGGAATLMRTFVKYPH 404
                    89*****8888*******..****************************9..888888999************************************ PP

                    GEEEEEEESECSSCCHHHHHHHHHHHHHH CS
  Abhydrolase_1  97 rVkalvllgaidpaaslieaqrqqaksfp 125
                      ++  l+      + ++e+ +q ++ ++
     EFC37162.1 405 LFHKRFLTHN----SVIGEWPLQFDNLLQ 429
                    9988777666....455555555555554 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.9   0.1     6e-11   1.2e-07       7      56 .]      30      79 ..      25      79 .. 0.92

  Alignments for each domain:
  == domain 1  score: 31.9 bits;  conditional E-value: 6e-11
       Ank_5  7 advnrldgggntpLhvAakygaadvvrlLlargadlnltdsrGltaldlA 56
                +  n ++++  tpLh+A+  +aa++vr+Ll+ ga++ + d++G++a+ +A
  EFC37162.1 30 ILANGRNKKNLTPLHIACDWNAAQCVRVLLEAGANREAVDDHGRNAFSFA 79
                66788999999**********************************99887 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   0.0   1.1e-10   2.2e-07       3      72 ..       7      91 ..       5     104 .. 0.76

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 1.1e-10
       Ank_2  3 lAakngnlelvklLlegadpn......k....ngktaLhyAakngnleivklLleh......adndgrtpLhyAarsghleivklL 72
                 +a+ +n+e +++Ll g+d +      +    +++t+Lh+A+  +  ++v+ Lle+      +d++gr++  +A r g +ei+++L
  EFC37162.1  7 DCAQTNNSERMEILL-GTDEKkrkilaNgrnkKNLTPLHIACDWNAAQCVRVLLEAganreaVDDHGRNAFSFAKRGGFIEIINML 91
                578877789999999.544222222221334689***********99*******966556777799********998999999998 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.0   0.0   1.4e-10   2.8e-07       4     137 ..     310     439 ..     307     463 .. 0.82

  Alignments for each domain:
  == domain 1  score: 30.0 bits;  conditional E-value: 1.4e-10
  Hydrolase_4   4 kavvvlvHGlaehsgryae..laeaLaaqGfavyalDhrGhGrsegkrghvpsfddyvdDlaafvekvkeehpelplfllGhSmGGliallyllrypd 99 
                  ++ v+ +HG+    + y+   la+aL ++G++v+ lD  G+G+s g++    ++  + +D   +v+++ e  +  ++ ++G   G+++ ++ + +yp+
   EFC37162.1 310 EKKVICCHGFSYCQSGYQWikLAAALHQRGWDVILLDLPGFGKSSGATH---QTRIWKNDGPDIVKTILEGLSLPRICVIGRCGGAATLMRTFVKYPH 404
                  6889******99999999555***********************66655...777888899999999999999999********************** PP

  Hydrolase_4 100 kva.glilsaPalkikaklkappllklllkllgkllpkl 137
                   ++ ++   +++++ ++     ++ +ll+k+  kl+ ++
   EFC37162.1 405 LFHkRFLTHNSVIGEWP----LQFDNLLQKTKTKLMVTW 439
                  88867777777777763....355555556666655555 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.4   0.0   2.4e-09   4.7e-06       1      85 [.     313     402 ..     313     449 .. 0.75

  Alignments for each domain:
  == domain 1  score: 27.4 bits;  conditional E-value: 2.4e-09
                    EEEE--GC.......GCHHHHHHHHCCT.CEEEEE--TTSTS-GGCS--HHHC....HHH.HHHHCCTT..TTSEEEEEETCHHHHHHH.HHHC CS
  Abhydrolase_6   1 vlllHGagss..assWlvapLaallaag.vhvlapDlpGhGrsdpppldledl....adl.aalldelaagggpvvlvGHSlGGalala.aapl 85 
                    v+++HG+++   +++W    Laa+l+++ + v+ +DlpG+G s+++ +  +       d+   +l++l  + ++++++G + G+a  ++ ++++
     EFC37162.1 313 VICCHGFSYCqsGYQWI--KLAAALHQRgWDVILLDLPGFGKSSGATHQTRIWkndgPDIvKTILEGL--SLPRICVIGRCGGAATLMRtFVKY 402
                    799***99883355555..9999999999777*********776666555332222388877788888..59999******9999777744444 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.1   7.6e-08   0.00015       4      32 .]      41      70 ..      39      70 .. 0.93
   2 ?   -3.8   0.0         9   1.8e+04      12      22 ..     365     375 ..     363     378 .. 0.76

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 7.6e-08
                BHHHHHHHHTTHHHHHHHH.TTTSTTCBTT CS
         Ank  4 TPLHlAatngkkriiklLL.hGAnlnaldn 32
                TPLH+A+  + +++++ LL  GAn  a+d+
  EFC37162.1 41 TPLHIACDWNAAQCVRVLLeAGANREAVDD 70
                *******9999********88***999985 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 9
                 HTTHHHHHHHH CS
         Ank  12 ngkkriiklLL 22 
                 n++++i+k +L
  EFC37162.1 365 NDGPDIVKTIL 375
                 56689999877 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   1.7e-06    0.0034       1      54 [.      39      91 ..      33      92 .. 0.95
   2 ?    0.7   0.0      0.43   8.5e+02      13      27 ..     328     342 ..     319     353 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 1.7e-06
       Ank_4  1 eltaLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklL 54
                +lt+Lh a+  +  ++vr Lle ga+  a+ ++ G++a+ +A ++g++ei+ +L
  EFC37162.1 39 NLTPLHIACDWNAAQCVRVLLEAGANREAV-DDHGRNAFSFAKRGGFIEIINML 91
                589***********************9999.888***********9****9988 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.43
       Ank_4  13 rlelvrlLlekgadi 27 
                  ++l++ L+++g+d+
  EFC37162.1 328 WIKLAAALHQRGWDV 342
                 57899*********6 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   1.8e-05     0.035       2      28 ..      39      64 ..      38      67 .. 0.91
   2 ?   -2.8   0.0       8.2   1.6e+04       1      21 [.      71      91 ..      71      95 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.8e-05
       Ank_3  2 GetpLhlAarsgnleivkfLlenkgad 28
                + tpLh+A+  +    v+ Lle  ga+
  EFC37162.1 39 NLTPLHIACDWNAAQCVRVLLE-AGAN 64
                68************99******.7887 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 8.2
       Ank_3  1 nGetpLhlAarsgnleivkfL 21
                +G++++ +A r g +ei+ +L
  EFC37162.1 71 HGRNAFSFAKRGGFIEIINML 91
                688888888888888887776 PP

>> Glyco_transf_9  Glycosyltransferase family 9 (heptosyltransferase)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00011      0.23      63     145 ..     258     345 ..     241     353 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00011
                     SHHHHHHHTTS-GGGS-SS---------HHHHHHHHHHTT........--SSS-EEEEE---TTGGGS--HHHHHHHHHHHHHTT-EEEE- CS
  Glyco_transf_9  63 haVernraLfaqaldlpkpeskpelalslkeraaaldaag........llaerpyivflpgaskdaKrWpeekyaelaealqekgyqvvLf 145
                     ++ ++ ++L+ ++ d++ +e +  l+++++  + +l+ a+        ++ + ++++ ++g s+ +     +++ +la+al+++g+ v+L+
      EFC37162.1 258 PISKKETKLVTESKDFDENEKQVLLNMKRQYFKINLQGAEytiharllQNDSEKKVICCHGFSYCQ---SGYQWIKLAAALHQRGWDVILL 345
                     5556778888888888888888777777777777777777888999888999999******99944...5789****************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1101  (0.0614089); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 3022.55
//
Query:       EFC37163.1  [L=978]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.6e-21   74.3   2.6    3.5e-09   36.9   0.1    3.1  3  DOMON          DOMON domain
    4.9e-17   62.2  16.1    1.3e-16   60.8  16.1    1.8  1  Ferric_reduct  Ferric reductase like transmembrane component
    4.6e-13   49.6   0.3    8.4e-10   39.0   0.3    2.7  1  NAD_binding_6  Ferric reductase NAD binding domain
    6.6e-07   29.4   0.1    1.5e-06   28.3   0.1    1.5  1  FAD_binding_8  FAD-binding domain
    4.5e-06   27.3   0.0    9.6e-06   26.2   0.0    1.6  1  NAD_binding_1  Oxidoreductase NAD-binding domain
  ------ inclusion threshold ------
        0.2   11.3   0.0       0.31   10.6   0.0    1.2  1  PrkA           PrkA serine protein kinase C-terminal domain


Domain annotation for each model (and alignments):
>> DOMON  DOMON domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.0   0.2   2.3e-12     7e-09      18     125 .]      82     191 ..      60     191 .. 0.81
   2 !   36.9   0.1   1.2e-12   3.5e-09      13     123 ..     288     400 ..     272     402 .. 0.81
   3 ?   -1.7   0.0       1.1   3.1e+03      81     103 ..     718     740 ..     715     746 .. 0.84

  Alignments for each domain:
  == domain 1  score: 36.0 bits;  conditional E-value: 2.3e-12
       DOMON  18 iefelsgkvntngyvaiGfsd..dgkMsnadvvvgwvd.ngrvyvqdyystggkgapriddtgsqditlls..gseengv..ttlkfrRkldtcdpkqd 109
                 +ef + +  +t+gy+++ f+     +M+++ +  ++++ +g ++v+d ++t++   p++d++  +di + +  ++ +ng+  t++k +R ++t+d+ +d
  EFC37163.1  82 LEFGAVA-LRTKGYLSFCFGYlsGDPMKGDTIFGFFNQaSGSITVMDAWMTNKPAPPTSDPS--DDIIQKNggFRTVNGIseTHMKWTRFVKTNDT-RD 176
                 5666674.568**********95446***99999999977*********9999999999977..77766664445566643399************.** PP

       DOMON 110 nkidldttvyviwaag 125
                  ++ ++t +++ wa++
  EFC37163.1 177 VVF-TNTAMRMSWAIH 191
                 ***.**********85 PP

  == domain 2  score: 36.9 bits;  conditional E-value: 1.2e-12
       DOMON  13 gdgdeiefelsgkvnt.ngyvaiGfsd..dgkMsnadvvvgwvdn.grvyvqdyystggkgapriddtgsqditlls..gseeng..vttlkfrRkldt 103
                 +++  ief l   ++   gy ++Gf +  +++M  ad ++g+vd+ g++ + d y++g+ +ap +d+t  q++ +++   +++ng   ++lk +R ++t
  EFC37163.1 288 ANNPIIEFGLL--ATGiYGYASLGFNHgaSSGMQTADTMFGYVDStGKAVIIDAYMQGNLQAPAPDTT--QNFISSNggLRSVNGnyELHLKWTRLVNT 382
                 56778999999..44349*********99999************66********************88..666555545455555125799******** PP

       DOMON 104 cdpkqdnkidldttvyviwa 123
                 +d+  d+++  + ++ + wa
  EFC37163.1 383 KDA-MDYTF-SNAQIPISWA 400
                 **9.*****.9999999888 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.1
       DOMON  81 itllsgseengvttlkfrRkldt 103
                 i ++ ++e++ vtt++ r+++ t
  EFC37163.1 718 IDSIKYDEKSQVTTITMRKPFLT 740
                 6788999************9866 PP

>> Ferric_reduct  Ferric reductase like transmembrane component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.8  16.1   4.4e-20   1.3e-16       4     124 ..     562     678 ..     559     686 .. 0.89

  Alignments for each domain:
  == domain 1  score: 60.8 bits;  conditional E-value: 4.4e-20
  Ferric_reduct   4 aalillplallla..lRnnflepltglsldklllfHkwlgvlafllallHvilyllnflrfsaldeerlldsllkkpynllGvlalllliilaitS 97 
                    a++  +++ l+l   +R ++l+ l+g+s+d+++ +H+wlg+l ++++++H+i++++++ +     +  +l + ++ ++ +lG++a++++ il++++
     EFC37163.1 562 ASVCVFNFGLILFpvTRYSVLQVLFGISFDRAIKYHRWLGILQWFFVTAHGIAMVVHYNA-----SGLYLVDVTSPTFPILGIIAWFFMTILWLMT 652
                    5555666666633359****************************************9997.....47999999999******************** PP

  Ferric_reduct  98 lkfirrrlsyelFyylHhllyvaylll 124
                    +++ir r  +e+F+++H++l +++++l
     EFC37163.1 653 FPVIR-RKLWEVFLISHVILSILIVIL 678
                    *****.6667*********99988875 PP

>> NAD_binding_6  Ferric reductase NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.3   2.8e-13   8.4e-10       1     153 [.     833     956 ..     833     958 .. 0.85

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 2.8e-13
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6   1 yenvllvagGiGitpfisilkdllkkskkealktkkikliwvvressslewfkdvLneleeeksegnieihiYlTseyeaedasdqlissiegens 96 
                    y+++++ +gGiGitp+ si  +ll+k      + k ++  w++  ++++++f    + le++ ++ n++ +i++++++++++++            
     EFC37163.1 833 YKTIVMFGGGIGITPVHSIYSHLLEKNV----QDKTVYTCWSIPTTDMIQVFP---QLLETNGNK-NLKPNIFISKMKDENSQQT----------- 909
                    789*********************9997....999******************...777788888.**********999877744........... PP

                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6  97 eslkqgvdavsgtrnvkihfgRPnlkevlkdi.....askhknssvgvfvCGppklvkevkk 153
                                   + ih gR n k+ l+++      + + n+ vgv+vCGp++lv  v++
     EFC37163.1 910 ---------------AFIHKGRANPKQFLEQVkkemkERGELNAYVGVLVCGPEQLVTSVSN 956
                    ...............346667777777777776665555788999************99988 PP

>> FAD_binding_8  FAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.1   4.9e-10   1.5e-06      14     107 ..     727     825 ..     716     827 .. 0.80

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 4.9e-10
  FAD_binding_8  14 edliklkvskpkkslkyka..GqyvyinipslsklfwqsHPFtiasape.......ddklslvikvk...sgltkklakkllssskkelenkkakl 97 
                    +++ +++++kp  ++ +++  G +++++ip++sk+  q HP t+ s +e        ++l+  + vk   sg++k++ak+  ++      +++++l
     EFC37163.1 727 SQVTTITMRKPFLTFGSNPsmGHFIFLYIPAVSKY--QHHPITVSSCKEidggmikKKELEFTVHVKnfgSGWSKQVAKVAQEK-----AQSANEL 815
                    6788999****99987765559***********77..*********99999999886666665555522369999999999998.....5778888 PP

  FAD_binding_8  98 kvlidGPYGa 107
                       ++G YG+
     EFC37163.1 816 ICRVEGAYGS 825
                    8889999996 PP

>> NAD_binding_1  Oxidoreductase NAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.0   3.2e-09   9.6e-06       1     108 [.     838     955 ..     838     956 .. 0.75

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 3.2e-09
                    EEEEGGGGHHHHHHHHHHHHHCTTCSEEEEEEEESSGCGSTTHHHHHHHHHHCTT..EEEEEEE.ESSCTTTSSSEESSHH.HHHHHHHHH..... CS
  NAD_binding_1   1 miagGtGiaPvrsvlraileeakdktkvvlvyGnrteedllyreeleelakklpg..rlkvvav.vsreeagweggkgrvq.dalleells..... 87 
                    m +gG Gi+Pv s+  ++le++ +++ v+  + ++t++ + +  +l e + +++   ++ + ++  ++ +++    kgr + +++le++ +     
     EFC37163.1 838 MFGGGIGITPVHSIYSHLLEKNVQDKTVYTCWSIPTTDMIQVFPQLLETNGNKNLkpNIFISKMkDENSQQTAFIHKGRANpKQFLEQVKKemker 933
                    889******************666799***********9998888888866655534554555565666666667777776233445544477667 PP

                    .HSSTTEEEEEECSHHHHHHHH CS
  NAD_binding_1  88 .lkkeethvyvCGppgMikavr 108
                       ++ + v+vCGp+++++ v+
     EFC37163.1 934 gELNAYVGVLVCGPEQLVTSVS 955
                    655888999********99886 PP

>> PrkA  PrkA serine protein kinase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0    0.0001      0.31      37     102 ..     871     933 ..     870     937 .. 0.93

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.0001
        PrkA  37 ispRyvikilsealssseakeekcinpldvlealeeglkeheviseeerekyleflevvreeyder 102
                 i+++++i+++ ++l+++    +k ++p   ++ +++  ++++ + ++ r+++++fle v++e++er
  EFC37163.1 871 IPTTDMIQVFPQLLETN---GNKNLKPNIFISKMKDENSQQTAFIHKGRANPKQFLEQVKKEMKER 933
                 7899*********9755...5999***************************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (978 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       886  (0.0494171); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.86u 0.31s 00:00:01.17 Elapsed: 00:00:00.50
# Mc/sec: 5839.72
//
Query:       EFC37164.1  [L=303]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-17   63.4   0.0    2.5e-17   63.0   0.0    1.1  1  Lactamase_B_2  Beta-lactamase superfamily domain
    2.6e-11   43.7   0.1    3.7e-11   43.2   0.1    1.3  1  Lactamase_B_3  Beta-lactamase superfamily domain
  ------ inclusion threshold ------
      0.019   15.0   0.1      0.048   13.6   0.1    1.7  2  Lactamase_B    Metallo-beta-lactamase superfamily


Domain annotation for each model (and alignments):
>> Lactamase_B_2  Beta-lactamase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.0   0.0   4.2e-21   2.5e-17       2     145 ..     138     302 ..     137     303 .] 0.80

  Alignments for each domain:
  == domain 1  score: 63.0 bits;  conditional E-value: 4.2e-21
                    EEEES--TT.......HHHHHTCGGS--S..SS--..SEEEEE-SS--HHHHGGGGCCCCC--EEEEEE.EEHHHHHHCCTTCGHHHCHTTTTEEE CS
  Lactamase_B_2   2 riLiDagpd.......lrqqalralqPve..lrdelppidaVllthaHyDHlaglltlrelrpkklply.apkgvlavleanfvylaleeepavnv 87 
                    +i++D++++        +++ +r   P +    ++lp+i++V+++h+HyDHl +   ++e+++++ p++  p ++  +   + +y +++ e ++++
     EFC37164.1 138 NIITDPVFSercspsqYFGP-KRIK-PIPfpDISKLPKIHFVIISHNHYDHL-DEHAFKEIQKHHDPIFlLPFKMKYKWMMK-HYSNSDAE-KEKL 228
                    89*******99988887777.6665.5555499*******************.88999997776656664553333333332.35566666.889* PP

                    EEE-TTSEEEE.......CSTTEEEEEEEE-EE--C.TCCE-TTTSEEEEEE........CTTEEEEEESS-S- CS
  Lactamase_B_2  88 heldwgesfel.......gdggleitatparhksgr.rldrnagdtlGlrie........gggkrvyyigDtgy 145
                    ++ldw++++++       + ++l++ + pa+h+s r ++drn+ ++ ++ ++        + +++++++gDtgy
     EFC37164.1 229 VDLDWWKETTFkvtaenqTVSNLSFVCLPAQHWSSRtGFDRNHVLWGSWGFKfdytdgneNVTRSFWHAGDTGY 302
                    *****************96679***************************9998886555444566*******98 PP

>> Lactamase_B_3  Beta-lactamase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.2   0.1   6.2e-15   3.7e-11       1      59 [.     121     223 ..     121     302 .. 0.68

  Alignments for each domain:
  == domain 1  score: 43.2 bits;  conditional E-value: 6.2e-15
  Lactamase_B_3   1 eltwlghnsflletagarilvDPf.......kanlgyeppa..................eeaDlvlisqaledHahletlkql............. 58 
                    ++tw+gh++fl++ +g++i++DP+       +        +                  +++  v+is+++ dH + ++ k++             
     EFC37164.1 121 QVTWIGHSTFLIQYRGVNIITDPVfsercspS--------QyfgpkrikpipfpdisklPKIHFVIISHNHYDHLDEHAFKEIqkhhdpifllpfk 208
                    69**********************66555331........1233335778889999999**********************987766666666666 PP

  Lactamase_B_3  59 ..............a 59 
                                  a
     EFC37164.1 209 mkykwmmkhysnsdA 223
                    666666666555552 PP

>> Lactamase_B  Metallo-beta-lactamase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1   8.1e-06     0.048       3      57 ..     124     186 ..     122     187 .. 0.90
   2 ?   -3.1   0.0       1.1   6.7e+03      96     109 ..     263     280 ..     230     293 .. 0.47

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 8.1e-06
                  CCSSEEEEEEETTCEEEES--SCHHHHHHHH........HHHHHTSGGGGEEEEE-SBSSHHH CS
  Lactamase_B   3 pdpvnsyliegdggviLiDtGtsteaaraal........elaalglkpkdvdavilTHlHlDH 57 
                  + +++++li+  g +i+ D+ +s++ +   +        +++    k+ +++ vi++H H+DH
   EFC37164.1 124 WIGHSTFLIQYRGVNIITDPVFSERCSPSQYfgpkrikpIPFPDISKLPKIHFVIISHNHYDH 186
                  5678899999999999999999999999988999999999999999***************** PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.1
                  HH....TTCHCGCCEEEE CS
  Lactamase_B  96 ll....lagvsadkpdvd 109
                  ++    +  v + +++++
   EFC37164.1 263 SRtgfdRNHVLWGSWGFK 280
                  333333444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (303 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       536  (0.0298957); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.42
# Mc/sec: 2166.23
//
Query:       EFC37165.1  [L=977]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.3e-41  141.4   1.0    3.3e-41  141.4   1.0    1.9  2  Pkinase         Protein kinase domain
    4.6e-31  108.0   0.3    8.3e-31  107.2   0.3    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
    1.2e-20   73.8   0.6      3e-10   40.6   0.0    3.2  3  Ank_2           Ankyrin repeats (3 copies)
    3.2e-15   56.3   1.0    1.5e-06   28.6   0.0    3.5  2  Ank_4           Ankyrin repeats (many copies)
    1.1e-14   53.1   0.7     0.0082   16.6   0.0    5.2  4  Ank_3           Ankyrin repeat
    1.2e-09   38.1   2.4       0.19   12.3   0.0    5.1  4  Ank             Ankyrin repeat
    1.9e-09   37.6   0.9      0.074   13.4   0.1    4.5  4  Ank_5           Ankyrin repeats (many copies)
    6.1e-08   32.5  11.0    6.1e-08   32.5  11.0    2.4  2  HECT            HECT-domain (ubiquitin-transferase)
     0.0013   18.7   0.0     0.0023   17.9   0.0    1.3  1  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.011   14.6   0.0      0.021   13.6   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase
       0.04   13.3   0.0      0.076   12.4   0.0    1.4  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
       0.08   13.5   0.5        2.5    8.7   0.0    2.8  2  NifW            Nitrogen fixation protein NifW
       0.21   11.8   3.6       0.29   11.3   1.6    2.3  2  Uds1            Up-regulated During Septation
       0.25   11.4  10.2       0.81    9.7  10.2    1.8  1  CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein C
       0.39   11.2   7.2        1.3    9.6   7.2    1.9  1  APG6_N          Apg6 coiled-coil region
       0.46   10.7   6.1        1.2    9.4   6.1    1.6  1  Jnk-SapK_ap_N   JNK_SAPK-associated protein-1
        9.5    6.3  11.9       0.49   10.5   3.2    3.1  3  Mod_r           Modifier of rudimentary (Mod(r)) protein


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.4       2.8   2.9e+03     196     230 ..     194     232 ..     182     245 .. 0.41
   2 !  141.4   1.0   3.1e-44   3.3e-41      12     259 ..     303     550 ..     293     556 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.8
                 STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHH CS
     Pkinase 196 pfsgekgkekvekeldqlekilkilg....etkeklpea 230
                 +f+ +++k ++  +++++e++ k l     e ++  +++
  EFC37165.1 194 IFEIKTQKRNKIGKVEEIERLEKKLSdmiqELSNMHERK 232
                 444333333333333333333333332222222222222 PP

  == domain 2  score: 141.4 bits;  conditional E-value: 3.1e-44
                 SEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHH.....HHSS--HHHHHH CS
     Pkinase  12 fGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee..kdelylvleyveggeladlle.....rkgslseeeakk 102
                  ++Vyka  k++++ v +K+i+ ++++    ++v++Ei  l  lk hp+i++l +vf e   +++y+ + y ++g+l ++++     ++    ++ +++
  EFC37165.1 303 LSVVYKAS-KSNSQVVILKEISLSENNC---ETVMNEIMNLVILKgHPRIIKLNGVFIEsqFNKVYIETPYYSNGNLLEYINkirnhHDLPTLKNMLRS 397
                 5799***9.7999***********9887...569***********************9866789*************999997764333335567999* PP

                 HHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHHTTSCB.SHHHHHHHHHHHHHHHHHSS-STTT CS
     Pkinase 103 iakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvlkeney.skkvDvWslGvilyelltgkppfsg 199
                 +++++ e l+++Hsk i+HrDlKp+NiL++e+ge  i+DFG +k+l  + +  t  vgt +Y+APEv +++e  s+k+D+WslGv lye     +  s 
  EFC37165.1 398 LFRKMTETLQFIHSKDILHRDLKPQNILVNENGEPIIADFGSSKKLIAQLTnNTMGVGTLKYMAPEVKRQEESpSEKSDIWSLGVSLYECWQLIQQISM 496
                 *********************************************99887768889************776666***************9765555554 PP

                 SSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 200 ekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                  ++ +    ++d      k++     ++  ++ei+ ++ ++l+ +++ +p++R++   ll
  EFC37165.1 497 MNNATVEILNFDS---KGKVV---LPTSTLNDEIDITLMKMLSHMFNSNPEDRPSSLTLL 550
                 4444433444444...44444...3467889999********************976655 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.2   0.3   7.9e-34   8.3e-31      23     253 ..     309     547 ..     297     552 .. 0.79

  Alignments for each domain:
  == domain 1  score: 107.2 bits;  conditional E-value: 7.9e-34
                  TTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHT..CTTTSBHHH.HHHHHHHHHH CS
  Pkinase_Tyr  23 ekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvct..keepllivteyvkgGdLlkfLrkk..ekekltlkd.llsfalqvAk 114
                   ++++++ V++K +  + +e++ e +++e+  +  l  hp+i+kl gv +  + ++++i t y ++G+Ll++++k   +++  tlk+ l s+  ++ +
   EFC37165.1 309 ASKSNSQVVILKEI--SLSENNCETVMNEIMNLVILkGHPRIIKLNGVFIesQFNKVYIETPYYSNGNLLEYINKIrnHHDLPTLKNmLRSLFRKMTE 404
                  45567777888998..66777789************99************5555679***************987621222233333145667899** PP

                  HHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.EEHHHHHHHHHHHHHHHHTTSSGT.TTTSH CS
  Pkinase_Tyr 115 GmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgesp.ypglk 210
                   +++++sk+++Hrdl  +N+L++en    i+DfG ++++    + ++++ +   +k+mapE+ ++++  ++ksD+Ws Gv l+E  +l ++  + +  
   EFC37165.1 405 TLQFIHSKDILHRDLKPQNILVNENGEPIIADFGSSKKL--IAQLTNNTMGVGTLKYMAPEVKRQEEsPSEKSDIWSLGVSLYECWQLIQQIsMMNNA 500
                  **************************************9..7888999999***********98877589*****************98764144445 PP

                  HHHHHHHHHTTEES-BBTTSBHH....HHHHHHHHT-SSGGGS--HH CS
  Pkinase_Tyr 211 neevleklkegkrlekpekcpee....lyelmkkcweedpeeRptfs 253
                  + e+l++ ++gk +   ++ ++e    l++++++ ++++pe+Rp+  
   EFC37165.1 501 TVEILNFDSKGKVVLPTSTLNDEiditLMKMLSHMFNSNPEDRPSSL 547
                  666677767777655555555541111677888999********865 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.6   0.0   2.8e-13     3e-10       3      81 ..      10      99 ..       8     101 .. 0.78
   2 !   30.8   0.1     3e-10   3.2e-07      28      80 ..     101     155 ..      94     158 .. 0.87
   3 ?   -2.0   0.0       5.5   5.8e+03      24      41 ..     297     316 ..     281     351 .. 0.55

  Alignments for each domain:
  == domain 1  score: 40.6 bits;  conditional E-value: 2.8e-13
       Ank_2  3 lAakngnlelvklL.l......egadpnkng.ktaLhyAakngnleivklLleh..adndgrtpLhyAarsghleivklLlek.gadinl 81
                +A+++gn e+++++ l      e  dp+++g  t L +A+ +g+l+iv+lLl+   +d +   pL++A+++g+ eivklLl   g+d+n+
  EFC37165.1 10 HAVSEGNIEFLRHIdLrpfinhEQDDPDDEGiVTLLCTACGRGHLKIVELLLNVdgVDVNKCGPLFFACQNGYVEIVKLLLSVdGIDVNQ 99
                5777887788888855654332224454455589999***************96788877788******************5479**996 PP

  == domain 2  score: 30.8 bits;  conditional E-value: 3e-10
       Ank_2  28 taLhyAakngnleivklLleh..adndgrtpLhyAarsghleivklLlekgadin 80 
                  +L  A+++g+ eivklLl++  ++ d + +Lh A+  g+++ivklLl k+a i 
  EFC37165.1 101 RVLREACEKGYFEIVKLLLDFdgINVDAYKALHGACYGGNFNIVKLLLAKNARIG 155
                 56778***************889999999*******889*********9888875 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 5.5
       Ank_2  24 k...ngktaLhyAakngnlei 41 
                 +   +g+++++ A k+++ ++
  EFC37165.1 297 QtlhTGLSVVYKASKSNS-QV 316
                 123467777777777764.32 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.6   0.0   1.4e-09   1.5e-06       3      55 .]      43      90 ..      42      90 .. 0.93
   2 !   24.3   0.0   3.2e-08   3.3e-05       4      55 .]     102     148 ..     100     148 .. 0.93

  Alignments for each domain:
  == domain 1  score: 28.6 bits;  conditional E-value: 1.4e-09
       Ank_4  3 taLhyaaisgrlelvrlLle.kgadinaqdnrsGetalhiAakrgnveilklLl 55
                t+L  a+  g+l++v+lLl+  g+d+n++       +l +A+++g+vei+klLl
  EFC37165.1 43 TLLCTACGRGHLKIVELLLNvDGVDVNKC------GPLFFACQNGYVEIVKLLL 90
                78999**************9559999999......6*****************8 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 3.2e-08
       Ank_4   4 aLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55 
                 +L  a+++g +e+v+lLl++ g++++a        alh A+++gn++i+klLl
  EFC37165.1 102 VLREACEKGYFEIVKLLLDFdGINVDAY------KALHGACYGGNFNIVKLLL 148
                 7899***************989999986......69****************8 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.0   0.00014      0.15       4      30 ..      43      69 ..      42      70 .. 0.92
   2 !   16.6   0.0   7.8e-06    0.0082       5      30 ..      73      98 ..      71      99 .. 0.96
   3 !   10.6   0.0   0.00071      0.75       6      30 ..     103     127 ..     100     128 .. 0.91
   4 !    7.0   0.0      0.01        11       4      27 ..     130     152 ..     129     156 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 0.00014
       Ank_3  4 tpLhlAarsgnleivkfLlenkgadvn 30
                t+L +A+  g+l+iv++Ll+  g+dvn
  EFC37165.1 43 TLLCTACGRGHLKIVELLLNVDGVDVN 69
                67779*********************9 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 7.8e-06
       Ank_3  5 pLhlAarsgnleivkfLlenkgadvn 30
                pL++A+ +g +eivk+Ll   g+dvn
  EFC37165.1 73 PLFFACQNGYVEIVKLLLSVDGIDVN 98
                9************************9 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00071
       Ank_3   6 LhlAarsgnleivkfLlenkgadvn 30 
                 L +A++ g +eivk+Ll+  g++v+
  EFC37165.1 103 LREACEKGYFEIVKLLLDFDGINVD 127
                 678***************99**998 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.01
       Ank_3   4 tpLhlAarsgnleivkfLlenkga 27 
                  +Lh A+  gn++ivk+Ll  k+a
  EFC37165.1 130 KALHGACYGGNFNIVKLLLA-KNA 152
                 68999**************9.666 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.1    0.0025       2.6       4      29 ..      43      70 ..      42      72 .. 0.87
   2 !   12.3   0.0   0.00018      0.19       5      29 ..      73      99 ..      71     101 .. 0.91
   3 ?    5.0   0.0     0.035        37       9      29 ..     106     128 ..     103     129 .. 0.84
   4 !    7.6   0.1    0.0055       5.8       5      23 ..     131     150 ..     131     154 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0025
                BHHHHHHHHTTHHHHHHHH..TTTSTTC CS
         Ank  4 TPLHlAatngkkriiklLL..hGAnlna 29
                T L  A+ +g++ i++lLL  +G ++n 
  EFC37165.1 43 TLLCTACGRGHLKIVELLLnvDGVDVNK 70
                777789999**********888*99995 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 0.00018
                HHHHHHHHTTHHHHHHHH..TTTSTTC CS
         Ank  5 PLHlAatngkkriiklLL..hGAnlna 29
                PL  A++ng ++i+klLL  +G ++n+
  EFC37165.1 73 PLFFACQNGYVEIVKLLLsvDGIDVNQ 99
                8999**************888999996 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.035
                 HHHHTTHHHHHHHH..TTTSTTC CS
         Ank   9 AatngkkriiklLL..hGAnlna 29 
                 A+  g  +i+klLL  +G n++a
  EFC37165.1 106 ACEKGYFEIVKLLLdfDGINVDA 128
                 67677789******877999987 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.0055
                 HHHHHHHHTTHHHHHHHH.T CS
         Ank   5 PLHlAatngkkriiklLL.h 23 
                 +LH A+++g+ +i+klLL +
  EFC37165.1 131 ALHGACYGGNFNIVKLLLaK 150
                 79999*9999*******954 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.0   0.00033      0.35      15      41 ..      40      67 ..      29      74 .. 0.71
   2 !    7.5   0.0     0.005       5.2      13      43 ..      69      98 ..      62     102 .. 0.79
   3 ?    4.1   0.0     0.059        62      23      37 ..     106     120 ..      92     128 .. 0.80
   4 !   13.4   0.1     7e-05     0.074       1      39 [.     118     151 ..     118     155 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00033
       Ank_5 15 ggntpLhvAakygaadvvrlLl.argad 41
                g +t L++A+ +g++ +v+lLl   g+d
  EFC37165.1 40 GIVTLLCTACGRGHLKIVELLLnVDGVD 67
                335*******************444444 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.005
       Ank_5 13 dgggntpLhvAakygaadvvrlLl.argadln 43
                +++g  pL +A+ +g+ ++v+lLl   g d n
  EFC37165.1 69 NKCG--PLFFACQNGYVEIVKLLLsVDGIDVN 98
                5553..999***************77666666 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.059
       Ank_5  23 AakygaadvvrlLla 37 
                 A+++g++++v+lLl+
  EFC37165.1 106 ACEKGYFEIVKLLLD 120
                 9*************3 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 7e-05
       Ank_5   1 LlehgpadvnrldgggntpLhvAakygaadvvrlLlarg 39 
                 Ll+ + ++v+++      +Lh A+++g++++v+lLla +
  EFC37165.1 118 LLDFDGINVDAY-----KALHGACYGGNFNIVKLLLAKN 151
                 677778888887.....*******************554 PP

>> HECT  HECT-domain (ubiquitin-transferase)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1       1.9     2e+03      77     104 ..     208     235 ..     155     332 .. 0.77
   2 !   32.5  11.0   5.8e-11   6.1e-08      27     287 ..     669     955 ..     649     969 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.9
                 TCHHHHH-HHHHHHHHHHH..HS-GGG. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT  77 ledleeidpelakslkellslesnteev 104
                 +e++e ++++l + ++el+++++ ++e+
  EFC37165.1 208 VEEIERLEKKLSDMIQELSNMHERKSEI 235
                 4556666666666666666666665553 PP

  == domain 2  score: 32.5 bits;  conditional E-value: 5.8e-11
                 E-TTHHHHS...............HHHHHHHHHHHHHT..T--BSS-B-HHHHHHHTT.....-.---TCH........HHHH-HHHHHHHHHHH..HS CS
                 xxxxxxxxx...........xxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxx.....xxxxxxxx........xxxxxxxxxxxxxxxxxxxx RF
        HECT  27 pkpssseee...........llklfeflGkvlGkaiye..eilldlpfsraflkfllg.....eekitled........leeidpelakslkellsles 99 
                 +++ss +e+            +++ ++lG +l k +++  + ++ lp++++++++ll+     +e+++++         l+e+d el +++ +++++++
  EFC37165.1 669 NSESSPNENfiltdepltdeSKNQLRTLGLLLKKLLIDcdDKTVYLPLNSFIFYYLLNgnalnKETLQFNAislllskfLREYDFELDNQIFSVKKCKN 767
                 222222222555556677777789************99889*****************8888755666666888888889999************9987 PP

                 -GGG...GT-..BSEEEEETTEEEEEESSTTGGGSB--TTTHHHHH..........................HHHHHHHHTGGGHHHHHHHHHHHHTTS CS
                 xxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..........................xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT 100 nteevedlaL..tFtipenagasatieLipnGanipVtnenkkeYi..........................klyvnyllkksvekqleaflkGfsevi 170
                 ++ e++++ +  tF           i+ +++ ++ p+  en++++i                            +++++   ++ ++l++fl+   + +
  EFC37165.1 768 DE-ELQSITMeeTF-----------IDVLSK-SEKPLIMENVQLFIisqlysyfysdlkieklklikqgfdwFNLTKFKQSSKLPPKLKEFLDLQGSNF 853
                 77.58888774444...........455555.56699999999999999999999***********999999788889999999999999999999999 PP

                 -HHHHTTS-HHHHHHHHBCSSS.--HHHHHHTEEEETT--TTSHHHHHHHHHHHHS-HHHHHHHHHHHHSSSS--TTCGGG-B--EEEEE-S..-TTS- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT 171 pskalklfdaeelellisGedelidvedlrrnteykggynaesetiewlweilkefspeekrlfLqFvTgssrlPlgGfaelhpkftierkskedetrL 269
                 ++k   +++ +el+ l+sG++  id + l + + +++    +  + + +++ ++++++++ r++L ++T+ s++P+ Gf+   +k+ i+  +     r 
  EFC37165.1 854 DEK---CLSVNELKILLSGQS-YIDADLLLNEIDMTR---ISPIMQDHFTKCIRKLTKSQLRQLLVWMTSLSSIPIRGFS---RKISIREYN-----R- 936
                 976...5668***********.5**********9865...44456678*******************************9...789998865.....3. PP

                 -EEEGGGTEEEE-.--SSH CS
                 xxxxxxxxxxxxx.xxxxx RF
        HECT 270 PtahTCfnlLklp.dYssk 287
                   +hTC   +++p + +++
  EFC37165.1 937 FESHTCSFVFDIPsQITNY 955
                 3689999999998534444 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   2.1e-06    0.0023     126     195 ..     376     439 ..     366     442 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.1e-06
                 HHHHHCHHHCCCGCCTCCHHHHHHHHHHHHHHHH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT CS
         APH 126 lrqlesatarllaselldlleeleeqvlaalaallpgelptvllHgDlhpgNllvdpddgrvtGviDfed 195
                 l+++++    + +++l+  l  + + + +++ ++l+   ++ +lH+Dl+p+N+lv++++ ++  + Df+ 
  EFC37165.1 376 LEYINKI---RNHHDLPT-LKNMLRSLFRKMTETLQFIHSKDILHRDLKPQNILVNENGEPI--IADFGS 439
                 5555555...34556666.66677889999999999988999**************999999..889985 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0     2e-05     0.021     316     389 ..     403     468 ..     386     480 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2e-05
  Pkinase_fungal 316 IkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkge 389
                      ++++  +  + iLHrD   +Nil++     ++ + +++D+   k+l    +  ++   +GTl++ma ev ++e
      EFC37165.1 403 TETLQFIH-SKDILHRDLKPQNILVN-----ENGEPIIADFGSSKKLIA--QLTNNTMGVGTLKYMAPEVKRQE 468
                     45555566.99***************.....456779*********996..44445789********9998864 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   7.2e-05     0.076     113     166 ..     386     437 ..     376     451 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 7.2e-05
         Kdo 113 ae..laeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDl 166
                 ++    +++ r l+++   + + +h+ ++ H+dl ++nil+++++    e ++ D+
  EFC37165.1 386 HDlpTLKNMLRSLFRKMTETLQFIHSKDILHRDLKPQNILVNENG----EPIIADF 437
                 44444567888999999*************************998....5555555 PP

>> NifW  Nitrogen fixation protein NifW
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.2      0.37     4e+02       4      45 ..     769     810 ..     766     819 .. 0.89
   2 ?    8.7   0.0    0.0023       2.5      13      75 ..     843     905 ..     832     912 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.37
        NifW   4 eelkelssaeeflefleveydpkvvnvnRLHILkrfsqylae 45 
                 eel++++  e f+++l  + +p +++  +L I+ ++ +y  +
  EFC37165.1 769 EELQSITMEETFIDVLSKSEKPLIMENVQLFIISQLYSYFYS 810
                 79999*****************************99998765 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0023
        NifW  13 eeflefleveydpkvvnvnRLHILkrfsqylaeedeaeeadeeealakaralLerAYedfves 75 
                  efl++ + ++d+k+++vn L IL   ++y+++    +e d + +   +++ +++  ++ ++s
  EFC37165.1 843 KEFLDLQGSNFDEKCLSVNELKILLSGQSYIDADLLLNEIDMTRISPIMQDHFTKCIRKLTKS 905
                 79************************9999998877666666666666666666665555555 PP

>> Uds1  Up-regulated During Septation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.6   0.00027      0.29      80     121 ..     200     241 ..     153     242 .. 0.87
   2 ?   -1.8   0.0       3.2   3.4e+03      89     117 ..     564     592 ..     538     618 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00027
        Uds1  80 sreslakaeeelaeserkvdelaselekleeraaevrrrLLe 121
                 +++++  + ee++ +e+k  ++ +el +++er+ e+++ L+e
  EFC37165.1 200 QKRNKIGKVEEIERLEKKLSDMIQELSNMHERKSEIQNDLME 241
                 44556667899****************************997 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 3.2
        Uds1  89 eelaeserkvdelaselekleeraaevrr 117
                 + l++s++k  e ++++  ++ r+ ++++
  EFC37165.1 564 DILSKSNQKELEGSEKISLWQARLKKMKQ 592
                 44444444444444444444444444444 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  10.2   0.00077      0.81      13      90 ..     164     240 ..     156     245 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00077
  CENP-F_leu_zip  13 KeserkadsLkdkvenLerelemseenqekvileaEtskaevetlkeeieelaeelreleldLvalrsekeeLekelq 90 
                     K+++ k+d++k    +++  +e++e  ++ +i e  t+k    +  eeie+l+++l+++ ++L+++ + k e++++l 
      EFC37165.1 164 KKIKPKKDLFKSL-AEIKDKIEDIEYAKDTLIFEIKTQKRNKIGKVEEIERLEKKLSDMIQELSNMHERKSEIQNDLM 240
                     6777788877765.458999*****************************************************99986 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   7.2    0.0012       1.3      26     115 ..     160     242 ..     147     254 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.0012
      APG6_N  26 daYeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreynelqlellel 115
                 +   e+ kk+k +k+  +    +l+e+++++e++e ++++l+ e+k  ++++    +e++ le++l+++ +e  +  ++ +e q +l+el
  EFC37165.1 160 K---EYDKKIKPKKDLFK----SLAEIKDKIEDIEYAKDTLIFEIKTQKRNKIGKVEEIERLEKKLSDMIQELSNMHERKSEIQNDLMEL 242
                 3...34455555555544....77778888888888888888888888888887788888888888888888888888877777777776 PP

>> Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.1    0.0011       1.2      54     152 ..     146     244 ..     142     246 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0011
  Jnk-SapK_ap_N  54 elreeleqLeteyerekelrkraeeeleeiedqweeerkelqekveqleeenrelelkaknaadqlsrleekeaelkkeysklheretellkklke 149
                    +l +++ ++ +e  +e  ++ + +++l +   +++++ ++++ +   l  e++  +       ++++rle+k +++ +e s+ her++e+ + l+e
     EFC37165.1 146 LLLAKNARIGKEERKEYDKKIKPKKDLFKSLAEIKDKIEDIEYAKDTLIFEIKTQKRNKIGKVEEIERLEKKLSDMIQELSNMHERKSEIQNDLME 241
                    566777777776666666666666666555555555555555555555555555553333557899****************************** PP

  Jnk-SapK_ap_N 150 lve 152
                    l+ 
     EFC37165.1 242 LIP 244
                    986 PP

>> Mod_r  Modifier of rudimentary (Mod(r)) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   3.2   0.00046      0.49      14      91 ..     169     246 ..     164     253 .. 0.91
   2 ?   -0.7   0.1       1.3   1.4e+03      13      45 ..     766     798 ..     764     823 .. 0.89
   3 ?   -1.7   0.1       2.8   2.9e+03       3      23 ..     858     878 ..     856     911 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00046
       Mod_r  14 deeklealvktlpevkqlkeekeellaeneslaeknlslepeleelrselqekleelkelekefeekeqeldellqkf 91 
                 +++++++l++  +++++++ +k+ l+ e++   ++++ + +e+e l ++l++ ++el +++++  e +++l el+ kf
  EFC37165.1 169 KKDLFKSLAEIKDKIEDIEYAKDTLIFEIKTQKRNKIGKVEEIERLEKKLSDMIQELSNMHERKSEIQNDLMELIPKF 246
                 57999999966699*******************************************************999999877 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.3
       Mod_r  13 edeeklealvktlpevkqlkeekeellaenesl 45 
                 +++e l++++ +   ++ l ++ + l+ en++l
  EFC37165.1 766 KNDEELQSITMEETFIDVLSKSEKPLIMENVQL 798
                 6899999999888889**************998 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 2.8
       Mod_r   3 lSkeeLqelledeeklealvk 23 
                 lS++eL+ ll+ +++++a + 
  EFC37165.1 858 LSVNELKILLSGQSYIDADLL 878
                 899999999999999887553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (977 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1419  (0.0791455); expected 358.6 (0.02)
Passed bias filter:                      616  (0.0343577); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.87u 0.38s 00:00:01.25 Elapsed: 00:00:00.55
# Mc/sec: 5373.57
//
Query:       EFC37166.1  [L=211]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00089   19.8  62.9    1.8e+04  -22.7  62.9    3.3  1  KRTAP           Keratin-associated matrix
  ------ inclusion threshold ------
      0.022   14.9  58.8    1.8e+04  -21.3  58.8    3.5  1  Keratin_2_head  Keratin type II head


Domain annotation for each model (and alignments):
>> KRTAP  Keratin-associated matrix
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -22.7  62.9         2   1.8e+04      38      38 ..     150     150 ..      81     211 .] 0.53

  Alignments for each domain:
  == domain 1  score: -22.7 bits;  conditional E-value: 2
       KRTAP  38 G 38 
                 G
  EFC37166.1 150 G 150
                 0 PP

>> Keratin_2_head  Keratin type II head
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -21.3  58.8         2   1.8e+04      82     123 ..     144     150 ..      71     211 .] 0.47

  Alignments for each domain:
  == domain 1  score: -21.3 bits;  conditional E-value: 2
  Keratin_2_head  82 gfglGfggGvglgfgagggvGggfGgggglvGgggfGgggfG 123
                     g+  G                                  g+G
      EFC37166.1 144 GL--GL---------------------------------GLG 150
                     00..00.................................000 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       265  (0.0147805); expected 358.6 (0.02)
Passed bias filter:                      205  (0.011434); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.32s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1320.40
//
Query:       EFC37167.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.06   13.2   4.0       0.08   12.8   3.2    1.7  1  RcpB      Rough colony protein B, tight adherence - tad - sub


Domain annotation for each model (and alignments):
>> RcpB  Rough colony protein B, tight adherence - tad - subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   3.2   4.5e-06      0.08      29     100 ..      78     148 ..      55     166 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 4.5e-06
        RcpB  29 entrvaqPvksdevnksllvkRyvladksdvayenlltevlrdvgsdkdkqihiissdkeakklakkirkrL 100
                 +  +  qP+++++ + sllv +  ++++s+ +  nl ++++  ++ d+ + i+ i +   +++   k+  ++
  EFC37167.1  78 KRLNEKQPTQKNDSKTSLLVTKSLFSNNSNSSNLNLNNSIAF-LNKDNTSPIKPIRESIYVNNNESKLASNM 148
                 566788******************************999875.44455555554444333333333332222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1187  (0.0662056); expected 358.6 (0.02)
Passed bias filter:                      192  (0.0107089); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.39u 0.23s 00:00:00.62 Elapsed: 00:00:00.38
# Mc/sec: 1784.88
//
Query:       EFC37168.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1101  (0.0614089); expected 358.6 (0.02)
Passed bias filter:                      284  (0.0158403); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1181.40
//
Query:       EFC37169.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-10   40.6   1.6    6.4e-10   39.3   0.6    2.3  2  HD        HD domain
  ------ inclusion threshold ------
      0.023   14.4   3.4       0.24   11.1   0.5    3.0  3  PDEase_I  3'5'-cyclic nucleotide phosphodiesterase


Domain annotation for each model (and alignments):
>> HD  HD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.3   0.6   7.1e-14   6.4e-10       1      74 [.      57     155 ..      57     255 .. 0.83
   2 ?   -2.3   0.0      0.54   4.8e+03      62      93 ..     362     394 ..     355     417 .. 0.74

  Alignments for each domain:
  == domain 1  score: 39.3 bits;  conditional E-value: 7.1e-14
                 HHHHHHHHHHHHHHHHHHHHH...........HHHHHHHHHHHHHTTTTHHHHTS..HHH...........HHH....CTCCHHHHHHHHHHHHHHHHH CS
          HD   1 rleHsleVaklarrlaedlge...........eedrellllaaLlHDiGkgpfgdafekk...........eee....fekflaHekvgaeilrevekr 73 
                 r+eH+l+Va+l++r+ ++  +            +d  +l++aaL+HD+G+gpf++ f++            e e    ++++++  + ++++l+e  ++
  EFC37169.1  57 RFEHCLGVAHLSKRWIDKFYHigsmkehnkpnFADMYILQVAALCHDLGHGPFSHVFDNEfipralnyrtpE-ErkngWTHEQGSKTMFEYMLEETTND 154
                 79***************9877*************************************99999999888851.34577888888888888888887776 PP

                 H CS
          HD  74 l 74 
                  
  EFC37169.1 155 I 155
                 6 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.54
                 HHHHHHHHHHHHHHHH.HHHHHHHHHTTCCHHH CS
          HD  62 vgaeilrevekrlgld.ledvaklirehheswe 93 
                  ++++l++++ r+ ++ +++++  i +h e + 
  EFC37169.1 362 KSRQLLKRIKRRQLYKfVDEIILPIDRHKEFES 394
                 577778888777755588888877777777665 PP

>> PDEase_I  3'5'-cyclic nucleotide phosphodiesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0     0.057   5.1e+02     205     222 ..      12      31 ..       1      43 [. 0.71
   2 ?   11.1   0.5   2.7e-05      0.24       5      53 ..      59     113 ..      55     126 .. 0.65
   3 ?    1.6   0.0     0.021   1.9e+02      88     126 ..     364     399 ..     339     428 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.057
                 H..HHHHHHHHHTHHHHHHH CS
    PDEase_I 205 a..ksqigFidfvvkplfea 222
                 +    qi Fi+ ++k ++++
  EFC37169.1  12 DeiHGQIAFISGICKQVIDT 31 
                 14489**********98875 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 2.7e-05
                 HHHHHHHHHHHHHHHC....CHCCCC..S-HHHHHHHHHHHHHTTTT--S--HHH CS
    PDEase_I   5 rHAadVlqalfyllkk....eklkee..ltpleilalliaalcHDvdHpGtnNsF 53 
                  H++ V++    ++ k    +++ke+   +  ++++l +aalcHD++H  ++  F
  EFC37169.1  59 EHCLGVAHLSKRWIDKfyhiGSMKEHnkPNFADMYILQVAALCHDLGHGPFSHVF 113
                 56666666655444321111334433446778999*************7666555 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.021
                 G-TTTTS-HHHHHHHHHHHHHHHHTTSGGGHHHHHHHHH CS
    PDEase_I  88 cnifknlskeeykelrkliielIlaTdmakhfelleklk 126
                  +++k +   ++++l k++ e+Il  d  k fe le+++
  EFC37169.1 364 RQLLKRI---KRRQLYKFVDEIILPIDRHKEFESLEEID 399
                 4666777...789999*******************9993 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       647  (0.0360868); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.23s 00:00:00.72 Elapsed: 00:00:00.41
# Mc/sec: 3658.86
//
Query:       EFC37170.1  [L=315]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.054   13.1   1.7        7.5    6.3   0.2    2.4  2  zf_UBZ    Ubiquitin-Binding Zinc Finger


Domain annotation for each model (and alignments):
>> zf_UBZ  Ubiquitin-Binding Zinc Finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.1   0.00058        10       3      14 ..      42      53 ..      40      57 .. 0.86
   2 ?    6.3   0.2   0.00042       7.5       3      14 ..     301     312 ..     299     313 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.00058
      zf_UBZ  3 ylCerCgkeipe 14
                 +C +C+++i++
  EFC37170.1 42 NQCNQCNHHISM 53
                68********86 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.00042
      zf_UBZ   3 ylCerCgkeipe 14 
                  +C++C++++++
  EFC37170.1 301 LPCDKCNSKFSI 312
                 68******9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       946  (0.0527637); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.43
# Mc/sec: 2216.59
//
Query:       EFC37171.1  [L=2246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-05   25.7   0.7    0.00019   21.7   0.0    3.6  3  DUF3677        Protein of unknown function (DUF3677)
  ------ inclusion threshold ------
      0.033   14.2   0.5       0.49   10.5   0.1    3.0  2  Cullin_Nedd8   Cullin protein neddylation domain
      0.079   13.2   0.4        2.2    8.6   0.1    3.2  2  Pox_EPC_I2-L1  Poxvirus entry protein complex L1 and I2


Domain annotation for each model (and alignments):
>> DUF3677  Protein of unknown function (DUF3677)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.0   3.1e-08   0.00019       2      72 ..     388     464 ..     387     476 .. 0.79
   2 ?   -3.8   0.0       2.8   1.7e+04      36      64 ..    1311    1339 ..    1307    1345 .. 0.72
   3 ?   -1.5   0.0      0.56   3.4e+03      16      54 ..    2125    2160 ..    2108    2165 .. 0.74

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 3.1e-08
     DUF3677   2 LrllssaagipevrllaasrleiwlqnpK..LsreaqeLLlslcvncntqs....sekdsevlsrLlklrlKtkali 72 
                 +r+ + + +  evr++aa+ +e wl+n     +++a +LL+ + + +  ++    +e d+  +++++ ++lK +++ 
  EFC37171.1 388 IRFCTYCVKVREVRSFAAKNMESWLGNTNlqIVKYAKDLLTRMSFYIREDQpdmfQEGDRVAFDYIVNMKLKPNNIQ 464
                 67889999********************96678*******9887777443322223445669***********9983 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 2.8
     DUF3677   36 qeLLlslcvncntqssekdse.vlsrLlkl 64  
                  q +L+s+ +n++  +se ++  +++ +++ 
  EFC37171.1 1311 QLILYSIEINMKE-ESEFNENiCFDAFVRT 1339
                  4468899999999.5555544599999886 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.56
     DUF3677   16 llaasrleiwlqnpKLsreaqeLLlslcvncntqssekd 54  
                   ++++ l+ ++ ++   r+++e+ + l+++c + ++ k+
  EFC37171.1 2125 HFIPQLLDLLIVKSN--RQVMEISYQLLIRCLQ-HDSKQ 2160
                  577888888888888..999***********66.55444 PP

>> Cullin_Nedd8  Cullin protein neddylation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.14   8.2e+02      45      62 ..     836     864 ..     811     865 .. 0.72
   2 ?   10.5   0.1   8.2e-05      0.49       6      36 ..     971    1003 ..     968    1032 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.14
  Cullin_Nedd8  45 kkrIesLiek...........eYleRden 62 
                   ++ Ie Li++           eYl R+e 
    EFC37171.1 836 RNIIEYLIKNqlqfmesdiesEYLVREER 864
                   5556666666666666666669*999986 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 8.2e-05
  Cullin_Nedd8    6 iqaaIVRiMKsrktlshneLvsevieqlsk..r 36  
                    ++ ++V i+K+r   + ++L++++ie+l+   r
    EFC37171.1  971 LCEYLVSILKRRNDTQNQNLIFQIIEKLKLylR 1003
                    67799**********************975343 PP

>> Pox_EPC_I2-L1  Poxvirus entry protein complex L1 and I2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.11   6.5e+02      27      56 ..     279     309 ..     278     313 .. 0.77
   2 ?    8.6   0.1   0.00037       2.2      22      68 ..     571     617 ..     567     621 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.11
  Pox_EPC_I2-L1  27 VksVLtdekaskktassgtklwlt.lliili 56 
                    V s L+ e+ s++  ss+++ w + ++  l+
     EFC37171.1 279 VTSLLSGEDISSNSPSSSSEEWNWeFICALF 309
                    7799999996666666667777777*99998 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00037
  Pox_EPC_I2-L1  22 nFievVksVLtdekaskktassgtklwltlliiliavlilvlllfly 68 
                    +F+++  s + + +++k+++ ++ k w+t l+ l+ ++il++++ + 
     EFC37171.1 571 DFVDLCSSLFVEREQMKQQNLQTRKRWITNLFELVRMIILSIIISHN 617
                    7***************************************9998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       808  (0.0450667); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.07u 0.31s 00:00:01.38 Elapsed: 00:00:00.51
# Mc/sec: 13123.66
//
Query:       EFC37172.1  [L=434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-42  145.0   4.6    8.6e-42  143.6   4.6    1.6  1  Dcc1      Sister chromatid cohesion protein Dcc1


Domain annotation for each model (and alignments):
>> Dcc1  Sister chromatid cohesion protein Dcc1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.6   4.6   4.8e-46   8.6e-42      17     332 ..      88     393 ..      71     394 .. 0.77

  Alignments for each domain:
  == domain 1  score: 143.6 bits;  conditional E-value: 4.8e-46
                 TTXSEEEESSSSXEEEEXSSXEEEEEEEEEEEEEEEEEEEXXSSXXXX.....XXSXXEEEEEEEEEEEEE.EEEEE--S-..--TT-........... CS
        Dcc1  17 geslvikgapdeeaVLctedkTyslkqvetSNslLLvteekeeeeekaeeeeeeksaqkkslvvsataseylElkeiaprld.klkelLre........ 106
                  + + ikg++++ a Lct+++++++++v+tSN++L++++++ e +                      +s ++E+++ + +l+ +++++L          
  EFC37172.1  88 PTAFYIKGENNSPAFLCTDSNSFEITRVDTSNTVLILDPSSGEIHGR--------------------VSCTYEITPSVVKLKeDIEKILPYypkngise 166
                 56689*******************************99988755554....................44444444444444434444442200000000 PP

                 .-EE-S-SSTHHHHH...TSS-S-SHHHHHHTSSS-HHHHHHHHH.HCTEE..EETTEEEEE-HHHHHHHHHHHHHHHHHTT--T.B-H..HHHHHHHH CS
        Dcc1 107 .peYdgeeeeeeedaksaeekekytleeLlenvqaSeaElkkaLk.elgal..eidGrlrllspsylselLelvlallveesldl.davpeeelveala 200
                  ++ +g+ + ++e++     ke++tleeL + ++aS++E+ + L+ e +a+  +  +r++ll++++  ++ el+l +l e s++   a++ e++ ++l 
  EFC37172.1 167 sETITGNVKFRSENK-----KEALTLEELESCIKASRNEILNCLTyECHAIcnDRTNRWYLLDQKLFFQIYELLLLMLAETSFSTkLALDRENVKKEL- 259
                 034444444444333.....344*********************9777777344579****************************99***********. PP

                 TTST--HHHHHHHHHHHEE......ES---EEE-HHHHHHHHHHHHHHHHSSS-EEHHHHHHHHHHTS-T...TSS.----GGGGT..TSEE-...... CS
        Dcc1 201 edgevpeevieqvlkvygkkesskekeeealkldekkvcralaeqlLkktkaekieleeFlekWkssvPe...gle.seldlelLr..Glalv.dsssk 292
                   ge+ + ++e++l++ +++ s +++    ++ld +k+c + a++l++++  +k++l++F ++W +s+ +    l+ ++ d++lL   G+ ++ +++++
  EFC37172.1 260 -GGEYDHLLLEHCLDLLSSQPSFNST----VELDINKICIFNAISLFNTH--NKWRLKDFQNTWDESMNSfqqALNyRNPDISLLIsqGYCVLvEEEKN 351
                 .566***********99988755444....68******************..***************98755545555567999954488777644444 PP

                 ......EEEE--GGGS-SSHHHHHHHHHHH-SEEEHHHHHHH CS
        Dcc1 293 kpee..riqyfpasdLPkdpkeRfkaLFklrpkWtleelepy 332
                  ++e   i+++++ dLP++ keR+  +Fk +pkWt++e+  y
  EFC37172.1 352 LSKEntMIHFLDRRDLPSQYKERLTRMFKCKPKWTFNEILIY 393
                 3333669********************************877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 2802.44
//
Query:       EFC37173.1  [L=1037]
Description: myosin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   2.6e-260  865.4   6.2   3.3e-260  865.0   6.2    1.1  1  Myosin_head   Myosin head (motor domain)
    4.8e-34  117.7   2.4    8.9e-34  116.8   1.5    1.9  2  Myosin_TH1    Unconventional myosin tail, actin- and lipid-bi
    2.4e-16   59.3   0.1    7.4e-16   57.7   0.1    1.9  1  SH3_9         Variant SH3 domain
    8.6e-16   57.3   0.1    2.1e-15   56.0   0.1    1.7  1  SH3_1         SH3 domain
    2.9e-13   49.3   0.0    6.2e-13   48.2   0.0    1.6  1  SH3_2         Variant SH3 domain
  ------ inclusion threshold ------
      0.024   13.6   0.1      0.076   11.9   0.1    1.8  1  AAA_10        AAA-like domain
      0.025   15.0   0.1      0.081   13.3   0.0    1.8  2  AAA_16        AAA ATPase domain
      0.063   12.8   0.5       0.71    9.4   0.1    2.3  2  Hpr_kinase_C  HPr Serine kinase C-terminal domain
      0.077   12.8   0.2       0.22   11.4   0.2    1.8  1  IQ            IQ calmodulin-binding motif
       0.15   11.4   0.1       0.33   10.2   0.1    1.5  1  Zeta_toxin    Zeta toxin


Domain annotation for each model (and alignments):
>> Myosin_head  Myosin head (motor domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  865.0   6.2  1.9e-263  3.3e-260       2     677 .]      16     668 ..      15     668 .. 0.97

  Alignments for each domain:
  == domain 1  score: 865.0 bits;  conditional E-value: 1.9e-263
                  SBGCGSSS-SHHHHHHHHHHHHHTT--EEEETTEEEEE--SS--STSSHHHHHHHTTS-GGGSSSSHHHHHHHHHHHHHHHTSEEEEEEESSTTSSHH CS
  Myosin_head   2 edlveLsllneasvlenlkkRykkdliYtysglvlvavnPykklkiysedvikaykgkkreelpPHifaiadeayrslledkenqsilisGEsGAGKt 99 
                  +d+v L +l+e++v+enlkkR+ +d+iYty+g+vl++vnP+k+++i+++++i++y+gk  +e pPH++a+a++ay++++++  +q+++isGEsGAGKt
   EFC37173.1  16 DDMVLLPKLSENEVMENLKKRHGSDVIYTYIGNVLISVNPFKQIPIFDQNFIDQYNGKYPYEEPPHVYALAETAYKNMKNNGDSQCVIISGESGAGKT 113
                  8************************************************************************************************* PP

                  HHHHHHHHHHHHHSSSSSCTCTTHHHHHHHHHHHHHHHHHEEEESSETTEESSEEEEEEEEETTSSEEEEEEEEECE-GGGGT---TT--SBHHHHHH CS
  Myosin_head 100 eatKkvlqylasvaeskekveeeeleekilqsnPilEafGnAktvrndnssRFGKfieiefdakgkiagakietYLLEksRvvkqakeERnyHiFYql 197
                  ea+K ++qy+a+v++      ++++++ il+snP+lEafGnAktvrn+nssRFGKf+ei+fd +g+++g+ki++YLLEksRvv+q+++ERn+HiFYql
   EFC37173.1 114 EASKLIMQYIAAVSGDGV--GVDRVKRIILESNPLLEAFGNAKTVRNNNSSRFGKFFEIQFDDRGDPIGGKITNYLLEKSRVVYQQAGERNFHIFYQL 209
                  **************9988..688*************************************************************************** PP

                  HHCSTHHHHHHTT--TCCGSTTTTTTSSSSBTTS-HHHHHHHHHHHHHHHT--HHHHHHHHHHHHHHHHHCTSSEEEECTTSSEEESSHHHHHHHHHH CS
  Myosin_head 198 lagaseeekkelkledvkdyaylsqsgeltvdgiddseefketkkaldilglseeeqkeifrivaailhlGniefkkeakdeqavledeeklekaael 295
                  +agas+eek+e+  ++++d+ ylsqsg+++vdgidd+ee++ t+ka+d++g+++eeq++i+r+va+il lGni+f+++ k+  +v+ed+ +l+ aa l
   EFC37173.1 210 CAGASKEEKEEFATTNAHDFYYLSQSGCYNVDGIDDAEEYQLTRKAMDVIGITKEEQSNIMRMVAGILWLGNITFREAGKG--SVVEDSGTLDYAAYL 305
                  ***************************************************************************998866..79999*9******** PP

                  HTS-HHHHHHHHHSEEEEETTEEEEEE-BHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSS-S-SEEEEEEEEE-B---SSB-HHHHHHHHHHHH CS
  Myosin_head 296 lgvdaeelekalvkrriktgkevvskalnveqaevardalakaiyerlFdwlverinkslekkkeekksfiGvLDiaGFEifeknsFEqlcinyvnEk 393
                  l+v + +l+ al++r ik+g+e ++++++  qa+++rdalak +y+rlFdwlv+rin ++++kk  ++ ++ vLDi+GFEif+kn+FEq+cinyvnEk
   EFC37173.1 306 LNVASDKLQFALLNRIIKSGNEEITVSQSPAQAANIRDALAKVLYARLFDWLVKRINDAMDTKK--NTLILAVLDIYGFEIFDKNGFEQFCINYVNEK 401
                  **************************************************************99..8999**************************** PP

                  HHHHHHHHHCHHHHHHHHHTTSSGCGS-GGGCCHHHHHHHHS.SSTSHHHHHHHHHTSTTS.....-HHHHHHHHHHHHTTSTTEEETTSTTTTTEEE CS
  Myosin_head 394 LqqlFnelvlklEqeeYvrEgiewkfidfgldnqaiidLiek.kplGilslLdeecllpka.....tdetfleklvkafskhakfeksrlkkgeakFi 485
                  Lqq+F++l+lk+EqeeY++Egi+w+ i++ ++n++++dLie+ +p Gi+s+Ld+ c++ ++      de+fl++l +  + +++f       ++++F 
   EFC37173.1 402 LQQIFIDLTLKAEQEEYTQEGIKWEPIQY-FNNKIVCDLIEEkNPPGIFSILDDTCNTTHSmearaADEKFLTRLREVVN-NPHFV-----GRTNEFS 492
                  *****************************.**********9979************998765555589999999987664.56774.....44689** PP

                  EEETTCEEEEE-TTHHHHHH----HHHHHHHHTSSSHHHHHHCCSHCHB--.........CSSSECCCCCSBHHHHHHHHHHHHHHHHCTSEEEEEEE CS
  Myosin_head 486 ikHyAgkveYevegfleKnkDtlnedlvellksskkkllaelfkeeekeakaeakksekkkkkkkkkkkfktvgskfkeslaeLmktlestnphfvRC 583
                  +kHyAg+v+Y+++gf +KnkD l+++l+++++s++++++++ f+e               + ++++kk+++++g+k+k+s  eL++tl++++ph++RC
   EFC37173.1 493 VKHYAGTVDYNIDGFTDKNKDVLYKTLIQCMQSTTNSFIRKFFPE---------------NVNENDKKRPESAGFKIKNSAVELVATLKKCEPHYIRC 575
                  ********************************************9...............2346677799**************************** PP

                  E-SSSS--TT---HHHHHHHHHHTTHHHHHHHHHHSSSEEEEHHHHHHHHGGGSTTSS-SS.SSSHHHHHHHHHHHTTS-GCGEEECSSEEEET CS
  Myosin_head 584 ikpnekkkakkldeslvleqlrclGvlegirirraGfpnRitfeefvqrYkllakkelkkllkedakkaveailkeleldkeeykiGktKiFfr 677
                  ikpne+k+++++d+++vl+q+++lG+le+ir+rraGf+ R  f++f++ +++l+kk+++++ k+d ++++e+ilk++ +d+ ey++GktKiF+r
   EFC37173.1 576 IKPNETKQPRDFDTKRVLHQVKYLGLLENIRVRRAGFAFRAPFQKFLNSFSVLSKKTWPQW-KGDPRTGCETILKDMGIDQGEYQMGKTKIFLR 668
                  *********************************************************9665.9*****************************98 PP

>> Myosin_TH1  Unconventional myosin tail, actin- and lipid-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       2.4   4.3e+03      49      80 ..     345     380 ..     329     386 .. 0.78
   2 !  116.8   1.5     5e-37   8.9e-34       1     172 [.     708     887 ..     708     905 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.4
  Myosin_TH1  49 dekvlFssr....vkKlnrssksskrilvlTdkaly 80 
                   kvl++      vk++n    ++k +l+l    +y
  EFC37173.1 345 LAKVLYARLfdwlVKRINDAMDTKKNTLILAVLDIY 380
                 4678888888888999**999999999999766666 PP

  == domain 2  score: 116.8 bits;  conditional E-value: 5e-37
  Myosin_TH1   1 kvlasellkgkKerrrfsllrkFegDYLglenesevgkelkkkvgkdqdekvlFssr....vkKlnrssksskrilvlTdkalylldpkkvk.....vl 90 
                 ++  ++ll+g+K+rrr sl+r+F gD+ ++ ++ ++++e+ kk g++ d  v+F +      kKl +     k   +lT++aly+++++kvk     ++
  EFC37173.1 708 RNTSADLLEGRKQRRRLSLNRNFLGDHANYMDN-AQLQEVMKKQGRKDDGGVVFGDIfmrpKKKLLKGVTFDKIWGLLTNEALYFIHREKVKkqfimDM 805
                 56789*************************888.99999999999999********999999**************************99999****99 PP

  Myosin_TH1  91 krriplseItsvsvsplqDdlvvlhlke.skgDllleldfktElvtklskaykkktnkklkvkisdtieyklkkkktrtvkfq 172
                   ri +++I+ vs+s+l+D+++++++++ + +Dl+le+++ktE++++l ++y+ k+n++++ ++++ ++++ +kkk +tvk  
  EFC37173.1 806 LCRISMNQIQCVSMSQLSDNWLAIQINDpNIDDLFLECENKTEFLAILNDQYRAKMNRDIPRTFENMLSFTENKKK-KTVKKA 887
                 9**************************98888************************************99988888.344432 PP

>> SH3_9  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.7   0.1   4.1e-19   7.4e-16       1      47 [.     987    1033 ..     987    1035 .. 0.97

  Alignments for each domain:
  == domain 1  score: 57.7 bits;  conditional E-value: 4.1e-19
       SH3_9    1 AlypyepreddeLsLqrGDvitvieesedgWlegsltGrtGlvPany 47  
                  +ly+y++  ddeL L++G++it+++++ +gW+eg++ G++Gl+P ny
  EFC37173.1  987 VLYNYQASADDELTLREGEIITLLDKDPSGWWEGEKQGKRGLFPGNY 1033
                  89********************************************* PP

>> SH3_1  SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.0   0.1   1.2e-18   2.1e-15       1      47 [.     986    1030 ..     986    1031 .. 0.97

  Alignments for each domain:
  == domain 1  score: 56.0 bits;  conditional E-value: 1.2e-18
                  EESSSBEXSSTTBXEBSTTEEEEEEEECSSSEEEEEETTSTEEEEEE CS
       SH3_1    1 iAlYDYeaeesdELsfkkGDviivleksedgWwkgrlkgtgkeGliP 47  
                  ++lY+Y+a+ +dEL++++G++i++l+k+ +gWw+g+ +  gk+Gl+P
  EFC37173.1  986 KVLYNYQASADDELTLREGEIITLLDKDPSGWWEGEKQ--GKRGLFP 1030
                  68************************************..69***** PP

>> SH3_2  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.2   0.0   3.4e-16   6.2e-13       2      57 .]     985    1037 .]     984    1037 .] 0.97

  Alignments for each domain:
  == domain 1  score: 48.2 bits;  conditional E-value: 3.4e-16
                  EEESS-B-SCGCCB--B-TTEEEEEE..EEEECTTEEEEEECCCEEEEEGCGEEEE CS
       SH3_2    2 vraiedyvgedkseLsfkkGdvikvlslgskdsdgwwegevgGrvGlfPsslveeq 57  
                  v+++ +y ++  +eL++++G++i +l   +kd+ gwwege++G++GlfP ++++e+
  EFC37173.1  985 VKVLYNYQASADDELTLREGEIITLL---DKDPSGWWEGEKQGKRGLFPGNYCQEI 1037
                  89999*********************...************************986 PP

>> AAA_10  AAA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   4.2e-05     0.076      10      59 ..      86     137 ..      81     155 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.2e-05
      AAA_10  10 anqevkgsktna.sas.liiGdlGnGKSvlakllvlyisllggkaliiDpkk 59 
                 a+ + k  k+n  s++ +i+G+ G+GK   +kl++ yi+++ g  + +D+ k
  EFC37173.1  86 AETAYKNMKNNGdSQCvIISGESGAGKTEASKLIMQYIAAVSGDGVGVDRVK 137
                 45555554444313345899**************************999976 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   4.5e-05     0.081      15      49 ..      89     124 ..      82     161 .. 0.76
   2 ?   -3.6   0.0       6.9   1.2e+04     110     126 ..     332     360 ..     302     376 .. 0.47

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 4.5e-05
      AAA_16  15 ale.rvrsgrpelvllsGesGvGKsslvrellrale 49 
                 a++ + + g++++v++sGesG GK+   + +++++ 
  EFC37173.1  89 AYKnMKNNGDSQCVIISGESGAGKTEASKLIMQYIA 124
                 55546678888**************88888876444 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 6.9
      AAA_16 110 elagaea............srllellkrl 126
                 + ++a+a             rl++ l + 
  EFC37173.1 332 SQSPAQAanirdalakvlyARLFDWLVKR 360
                 22333331111222233334454444444 PP

>> Hpr_kinase_C  HPr Serine kinase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1    0.0004      0.71      21      61 ..     102     141 ..      99     150 .. 0.86
   2 ?    0.7   0.0      0.19   3.3e+02      80     144 ..     373     437 ..     356     454 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0004
                   EEEEESTCHHHHHHHHHHHTTT-EEEEESSEEEEEETTE.E CS
  Hpr_kinase_C  21 vLitGesgvGKselaleLikrghrLvaDDaveikridektl 61 
                   v+i Gesg GK+e a +Li +    v+ D v + r+++  l
    EFC37173.1 102 VIISGESGAGKTE-ASKLIMQYIAAVSGDGVGVDRVKRIIL 141
                   89**********9.569**************9999987655 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.19
                   EEEHHHHH-GGGB-SEEEEEEEEEEESTT---TTTSTTSS-EEEEETTEEEEEEEEE--TTS-HH CS
  Hpr_kinase_C  80 iidvkklfGaeavrekkeielvveLeewekkkeydrlgleeetkeilgvkvpkvtipvkpgrnla 144
                   i+ v +++G e + ++   +++++ ++ + ++ +  l+l++e++e+++  ++   i+  + + + 
    EFC37173.1 373 ILAVLDIYGFEIFDKNGFEQFCINYVNEKLQQIFIDLTLKAEQEEYTQEGIKWEPIQYFNNKIVC 437
                   55666667777666666666777777666666666666666666666666555555555554444 PP

>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2   0.00012      0.22       2      20 ..     686     704 ..     685     705 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00012
                 HHHHHHHHHHHHHHHHHHH CS
          IQ   2 kaaikIQaawRGylaRkry 20 
                 + a+ +Q+ wR y+ ++++
  EFC37173.1 686 DNATQMQRLWRNYKLKRYF 704
                 679**************98 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.1   0.00018      0.33      13      41 ..      96     124 ..      86     139 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00018
  Zeta_toxin  13 qerPklillgGqpGAGKselaellkdele 41 
                 +     ++++G +GAGK+e+++l+ ++++
  EFC37173.1  96 NGDSQCVIISGESGAGKTEASKLIMQYIA 124
                 5566789***************9998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1037 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       868  (0.0484132); expected 358.6 (0.02)
Passed bias filter:                      599  (0.0334096); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.48
# Mc/sec: 6436.82
//
Query:       EFC37174.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 1223.24
//
Query:       EFC37175.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-15   57.0   0.1    3.7e-15   56.1   0.1    1.5  1  C2               C2 domain
     0.0091   16.1   0.8        2.8    8.1   0.1    2.4  2  FPRL1_inhibitor  Formyl peptide receptor-like 1 inhibitory pr
  ------ inclusion threshold ------
        1.4    9.8   4.8        9.4    7.1   0.1    2.8  3  TORC_N           Transducer of regulated CREB activity, N ter


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.1   0.1   6.3e-19   3.7e-15       2      95 ..       8     121 ..       7     129 .. 0.85

  Alignments for each domain:
  == domain 1  score: 56.1 bits;  conditional E-value: 6.3e-19
                 EEEEEEEEEESSSSSSTTSSCEEEEEEEE..............ECEEEEEE-SCSSSSSSEEEEEEEEEESC....HTTSEEEEEEEEECSSSTEEEEE CS
          C2   2 klevtvieAknLpnkdkkgssdpyvkvsl..............dgkqkakTrviknslnPvWnekftfevae....leeakLeveVfdndrlskddfiG 82 
                 +l+vt+++AknL++ d +g s + v+++               +++ ++kT+v+k++lnP+Wne+ tf+           kL++eV+d+d lskdd iG
  EFC37175.1   8 TLTVTIKHAKNLEAADLNGFSYVIVQAKSaidderfddimketAKEWRQKTSVKKKTLNPEWNEDKTFHSLLyldtGLGIKLKFEVYDWDLLSKDDPIG 106
                 69***************99987777777799*********99888888999999***********999433347888999******************* PP

                 EEEEEGHH..HHTTH CS
          C2  83 kveiplst..llsge 95 
                 ++ei l+   l++++
  EFC37175.1 107 QAEILLDGdkLEHDR 121
                 ****99885444444 PP

>> FPRL1_inhibitor  Formyl peptide receptor-like 1 inhibitory protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.1   0.1   0.00048       2.8      19      44 ..      36      64 ..      18      71 .. 0.72
   2 !    6.2   0.0    0.0019        11      14      80 ..     211     278 ..     203     285 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00048
  FPRL1_inhibitor 19 akkdderidklmkesdknl...tpykaet 44
                     +  dder d +mke+ k+    t  k +t
       EFC37175.1 36 SAIDDERFDDIMKETAKEWrqkTSVKKKT 64
                     3369**********998641115555555 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0019
  FPRL1_inhibitor  14 nladqakk.dderidklmkesdknltpykaetvndlylivkklsqgdvkkavvrikdggprdyytfdl 80 
                      ++ad ak+  d++i  + ke  k     k e vn      +kl    ++  ++  k gg r + tf +
       EFC37175.1 211 KFADIAKQvSDQKISDMKKEYSKVEVKSKNEHVNPDPHCRNKLITNIMEYILLLEKKGGIRMWGTFRI 278
                      5788888646899*********************9999999999988888889999999999998876 PP

>> TORC_N  Transducer of regulated CREB activity, N terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.1    0.0016       9.4      13      44 ..      33      64 ..      30      78 .. 0.80
   2 ?   -3.2   0.1       2.6   1.6e+04      18      32 ..     181     195 ..     179     198 .. 0.77
   3 ?    3.9   0.1     0.015        91      20      51 ..     209     244 ..     207     260 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0016
      TORC_N 13 nqKqaEetaaFekimrevsaatrketqssnak 44
                + K a + + F++im+e  +  r++t+ ++++
  EFC37175.1 33 QAKSAIDDERFDDIMKETAKEWRQKTSVKKKT 64
                56888899*********999999999887766 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.6
      TORC_N  18 EetaaFekimrevsa 32 
                 Eet a + +  +++ 
  EFC37175.1 181 EETDAHNAVFADMKR 195
                 899999999888765 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.015
      TORC_N  20 taaFekimrevsaatrketqssnak....saaalai 51 
                 +a+F +i ++vs+ + ++++++ +k    s+++   
  EFC37175.1 209 NAKFADIAKQVSDQKISDMKKEYSKvevkSKNEHVN 244
                 799************999998877766663333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       920  (0.0513135); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 1961.96
//
Query:       EFC37176.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3722  (0.207597); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                       243  (0.0135535); expected 17.9 (0.001)
Passed Fwd filter:                        86  (0.0047967); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.39u 0.42s 00:00:01.80 Elapsed: 00:00:00.67
# Mc/sec: 1051.68
//
Query:       EFC37177.1  [L=440]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-53  181.4  32.7    2.9e-53  181.0  32.7    1.1  1  CRT-like  CRT-like, chloroquine-resistance transporter-like
    2.8e-07   30.3  17.2    2.8e-07   30.3  17.2    2.5  2  SLC35F    Solute carrier family 35
    0.00012   22.3  42.2    0.00052   20.2  16.7    3.2  3  EamA      EamA-like transporter family


Domain annotation for each model (and alignments):
>> CRT-like  CRT-like, chloroquine-resistance transporter-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.0  32.7   4.8e-57   2.9e-53       3     334 .]      82     407 ..      80     407 .. 0.91

  Alignments for each domain:
  == domain 1  score: 181.0 bits;  conditional E-value: 4.8e-57
    CRT-like   3 iyvvllvlsgviNsillKkvlnklkNysfflnql.tnfvyvpiffavvlykllltndipketrsfpkrkFaimgaLDavsgilvvigavstsGslqvll 100
                 ++v+++ +s  iN +l+ +   ++k y++fl+ + +  +  +++  + ++k++ t +++ke+r+fp ++F+img+L  ++ ++ vi++ ++sGs+ v +
  EFC37177.1  82 LVVLVMAFSRSINFVLIVRLSTQMKHYGYFLSSIlIPTMSNIVYWPIAWFKMFGTRSVTKEMRKFPVYRFVIMGFLTNLANLILVIASSNVSGSVNVAM 180
                 678899999**********************9862455666777788999************************************************* PP

    CRT-like 101 nqaiipitllasllllkerysliqylGAlviilgvvvvlipsllgesse..gnklvfnllllisviPvalSnvykeiafkeveldvlyLqawvalfqll 197
                 nq+ii  ++l+s+++l  ry+++q++G +++i+gv++ + p  l + s+  + + ++ l+llis+   a++nvy e  +k+ +ldv y+ aw+ lfqll
  EFC37177.1 181 NQTIIINNMLVSMIFLSVRYNILQFGGTFIVIIGVILNVLPLFLSGRSGtsSTEWIWALVLLISTFFQAIANVYIEHYLKKEKLDVFYMVAWIELFQLL 279
                 *************************************999988775555125799******************************************** PP

    CRT-like 198 igi.lllpvnal.llkpaki.kfkeileslkdGlaCllgkntiveevlscgldeqkscDdCekawivvllyllvNiiyNilillvlkhagatvlsiast 293
                 +gi + +p   +  ++++ + + +++++ +   l+C++g n++             + D C++++ v +l+ ++N++ N+  l+v kh+++t+ +ia t
  EFC37177.1 280 FGIlFFIPFLLIpWNPNSIVkSASDLPNYMLYSLKCVVGMNSL-------------KGDICDGVYWVAILFEVFNVLFNVTQLVVFKHGSSTLAMIALT 365
                 **94455776664344444435789*****************9.............469**************************************** PP

    CRT-like 294 lrlPltnivfslkfivgke.vtplsaldvaglliillGlvlY 334
                  rl + n++f+++fi+g + +++ls ld+ +l+i++ G+vlY
  EFC37177.1 366 SRLVMSNLFFMIPFIAGPAfQQKLSNLDIESLFILVAGIVLY 407
                 *****************6626789****************99 PP

>> SLC35F  Solute carrier family 35
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3  17.2   4.8e-11   2.8e-07      43     207 ..     116     283 ..      71     323 .. 0.75
   2 !    3.7   5.0    0.0061        37     229     298 ..     331     408 ..     318     409 .. 0.68

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 4.8e-11
      SLC35F  43 lnyvllalvytgillfrrgaekll..eilkrkwykylllalvdveanylvvkayqytsltsvqlldcfaipvvlvlswlflkvryrlvkiigvvvcilG 139
                 l  ++  +vy +i  f++   + +  e+ k   y++++++++   an ++v a  + s      ++   i   +++s++fl vry+++++ g ++ i+G
  EFC37177.1 116 LIPTMSNIVYWPIAWFKMFGTRSVtkEMRKFPVYRFVIMGFLTNLANLILVIASSNVSGSVNVAMNQTIIINNMLVSMIFLSVRYNILQFGGTFIVIIG 214
                 344455799999999998554444115666678********************99998655556677777788999*********************** PP

      SLC35F 140 vvllvvsdvlagrransgsnpvlGdllvlaGatlyavsnvleeylvk..klslvellgllglfGaiisai 207
                 v+l v    l+gr + ++s + +  l++l+ +   a++nv+ e+ +k  kl++  +++ + lf  ++ ++
  EFC37177.1 215 VILNVLPLFLSGRSG-TSSTEWIWALVLLISTFFQAIANVYIEHYLKkeKLDVFYMVAWIELFQLLFGIL 283
                 ************999.5555666677778888889*****86655551358899999*****98776554 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0061
      SLC35F 229 lfvgfalvlf.llysllp.ilikktsatsvnlsl....ltsdlysl..liglflfhykvswlyllafvviliGlilys 298
                 ++v+    +f +l+ +   +++k+ s+t+  ++l    + s+l+ +  +i   +f++k+s l + ++++++ G++lys
  EFC37177.1 331 YWVAILFEVFnVLFNVTQlVVFKHGSSTLAMIALtsrlVMSNLFFMipFIAGPAFQQKLSNLDIESLFILVAGIVLYS 408
                 555555544423444444167899999987776422215567776633466679***********************8 PP

>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2  16.7   8.7e-08   0.00052       4     136 ..      81     219 ..      78     220 .. 0.86
   2 !   12.8   4.0   1.6e-05     0.098       2      72 ..     236     313 ..     235     322 .. 0.77
   3 ?    1.5   5.6      0.05     3e+02       6      73 ..     337     406 ..     329     410 .. 0.53

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 8.7e-08
        EamA   4 illallaalfwaiyfvlskillrkvspltltfvrfl...iagillliiallkegklaklslkd..wlll.lllgllgtvlafllffyalkktsasnasl 96 
                 +l++l+ a++ +i+fvl+ +l++++  + ++  ++l   ++ i+  +ia++k    ++ +++   +  + +++  + t la+l++++a +++s s+ + 
  EFC37177.1  81 CLVVLVMAFSRSINFVLIVRLSTQMKHYGYFLSSILiptMSNIVYWPIAWFKMFGTRSVTKEMrkFPVYrFVIMGFLTNLANLILVIASSNVSGSVNVA 179
                 578999*******************9998888777766789999999999999999555555533333346666688889999**************** PP

        EamA  97 itslePvftlilsvlllgekltlkqllgivlillGvllil 136
                 ++ ++ +  ++ s+++l  + +++q+ g++++++Gv+l +
  EFC37177.1 180 MNQTIIINNMLVSMIFLSVRYNILQFGGTFIVIIGVILNV 219
                 *************************************976 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.6e-05
        EamA   2 lgillallaalfwaiyfvlskillrkv..spltltf....vrfliagillliiallkegkl.aklslkdwllllllgl 72 
                 +++l++l++++f ai+ v++ + l+k   + + +++    +++l++ +++++++l+ ++++  + s +d+  ++l++l
  EFC37177.1 236 IWALVLLISTFFQAIANVYIEHYLKKEklDVFYMVAwielFQLLFGILFFIPFLLIPWNPNsIVKSASDLPNYMLYSL 313
                 688999*****************877655777777766668999***************9965555555555555544 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.05
        EamA   6 lallaalfwaiyfvlskillrkvspltltfvrfliagill...liiallkegklaklslkdwllllllgll 73 
                 + +  +lf  +  v+ k++++++  ++lt  r++++ +++   +i  + +++kl++l+ +++++l+   +l
  EFC37177.1 337 FEVFNVLFNVTQLVVFKHGSSTLAMIALTS-RLVMSNLFFmipFIAGPAFQQKLSNLDIESLFILVAGIVL 406
                 444556666666777777777777777775.6666666663222223344444455555554444433333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (440 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       912  (0.0508673); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.71u 0.34s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 2423.90
//
Query:       EFC37178.1  [L=477]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.2e-30  104.0   1.4    9.2e-30  104.0   1.4    1.5  2  UCH       Ubiquitin carboxyl-terminal hydrolase
    5.2e-11   42.7   0.3    9.9e-11   41.8   0.3    1.5  1  zf-UBP    Zn-finger in ubiquitin-hydrolases and other protein


Domain annotation for each model (and alignments):
>> UCH  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1      0.69   6.1e+03      35      42 ..      19      26 ..       5      57 .. 0.52
   2 !  104.0   1.4     1e-33   9.2e-30      12     257 .]     177     474 ..     166     474 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 0.69
                CCSSTCCC CS
                xxxxxxxx RF
         UCH 35 vkkesrnk 42
                +++++++k
  EFC37178.1 19 EDTNNHHK 26
                11111111 PP

  == domain 2  score: 104.0 bits;  conditional E-value: 1e-33
                 HHHHHHHHHTSHHHHHHHHTCHHCCSSTCCCCC-.TT.TTS.TTHHHHHHHHHHHHHH..SH-CCEE--HHHHHHHHHHSGGGTSSSTCEHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH  12 mnsvlQcLfsipelrdyllsleevkkesrnkkelnesnplgkkgelakalkdlfkell..kskskavsPkklkktlsklaksfsgykqqDaqEflaflL 108
                 +n ++Q+L+ i++ rd++l        ++n         ++ k + +  +++l+++++  k+ +++v+P ++++++ + ak+f+ ++  D   f++ lL
  EFC37178.1 177 INVAIQALTRIKPVRDFFLLD------QKNL--------SKVKSRSVLLFSELLRKIWnpKNFKNHVNPLEFVQSILSNAKQFKLGESIDPVQFFTWLL 261
                 799**************9993......2222........2223346778*********9977899********************************** PP

                 HHHHHHHCCHCCCHHHHHHCCCTTSHHHHHH-EEEEE.............................................................. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.............................................................. RF
         UCH 109 dqlhedlnrevaeekwkkhlkrndslitdlfegqlks.............................................................. 145
                 + lh +l +         ++ +++s+i++ f+g+++                                                               
  EFC37178.1 262 NYLHGELTD---------NQPKQKSIISESFRGRITItskvikrkksggadkkqveettsqnttpfmfltldvpsapifkdeyernilpqvslfsllsk 351
                 *******99.........67788899999999998888899999999**************************************************** PP

                 ...................EEEEEEB-SEEEEEEESEEETEE.EEE--SEEB--S.EEE-GGGBSS-BTTS-TCS-BEEEEEEEEEESCTTSEEEEEEE CS
                 ...................xxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH 146 ...................klklkrlPeiLiihlkRfsynss.ksKlntkvefpe.eldlssylaeekkkkteekkkYeLiavvvHsGslssGHYvayi 223
                                    k k+++lP++L++h+kRfs n   ++K+nt v+fp+ +ld+s+++ + + ++      Y+L+a ++H Gs+ + H    +
  EFC37178.1 352 fngeketavplndgnvemrKYKIEKLPPYLVFHVKRFSKNFFfEEKNNTIVNFPLnNLDISEIAPDYSGSH------YNLVANICHDGSVYKIH----V 440
                 ***************************************999************879****9887555554......***********875555....5 PP

                 ECTTTTEEEEEETTEEEEE-HHCCCTT.CEEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxx RF
         UCH 224 knekngkWykydDetvkevkeeeevls.sayiLfY 257
                  n ++gkWy ++D  vkev +e ev+  ++++L+Y
  EFC37178.1 441 HNVAEGKWYEIQDLDVKEVIAE-EVSIsQSFLLVY 474
                 555679*************988.555559999999 PP

>> zf-UBP  Zn-finger in ubiquitin-hydrolases and other protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.8   0.3   1.1e-14   9.9e-11       1      63 [.      63     124 ..      61     125 .. 0.94

  Alignments for each domain:
  == domain 1  score: 41.8 bits;  conditional E-value: 1.1e-14
                 -TTTH--.SSEEEETTT--EEE-TTTT-HHHHHHHHH---EEEETTT--EEETTTTEEBE-GC CS
      zf-UBP   1 CseCnsenknlWlCLkCghvgCgrksnghalkHyeetrHplavdlstlsvycyscddevedke 63 
                 Cse  s+ +n+++CL +g+++ g+ ++  a+ H  +++H+l++++s++++yc+++++ev+dk+
  EFC37178.1  63 CSETLSN-TNVYCCLVDGKFFKGKGESTPAYIHSLNEDHHLFMSISNGKIYCLPDNYEVNDKS 124
                 6677766.9***************************************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (477 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       787  (0.0438954); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.30s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 2819.59
//
Query:       EFC37179.1  [L=947]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.4e-52  176.5   1.3    9.1e-52  176.0   0.4    1.7  2  Pkinase         Protein kinase domain
    7.1e-52  176.2   0.1    4.3e-51  173.7   0.1    2.1  1  Pkinase_Tyr     Protein tyrosine kinase
  ------ inclusion threshold ------
       0.02   13.7   0.0      0.044   12.6   0.0    1.5  1  Pkinase_fungal  Fungal protein kinase
      0.098   13.2  16.7        0.5   11.0   0.6    4.6  4  Chlam_PMP       Chlamydia polymorphic membrane protein (Chlam


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       1.2   5.4e+03     113     135 ..      75      97 ..      72     121 .. 0.75
   2 !  176.0   0.4     2e-55   9.1e-52       3     259 ..     658     935 ..     656     938 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.2
                 HHHHTTEE-SS-SGGGEEEETTT CS
     Pkinase 113 ylHskgiiHrDlKpeNiLidekg 135
                  +Hs  ++   l  +N+Li++++
  EFC37179.1  75 QCHSDLLVMSELNVKNLLINQSN 97 
                 68888888889999999999543 PP

  == domain 2  score: 176.0 bits;  conditional E-value: 2e-55
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS--H CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgslse 97 
                  ++k+GeG++G+Vyk++  +++  vA+K++k++ ++++ e    rE  ++ +l+hp iv +y++  ++++ y+++ey+++g l+ ++      k++ls 
  EFC37179.1 658 IVKKIGEGASGVVYKGL--WNKTDVAIKQFKTDTDDEEFE----REALLMSSLRHPSIVSCYGISLSTESKYMIVEYLSNGALDGAIYeskiGKKKLSY 750
                 689**************..9999**********9998776....****************************************999855444445555 PP

                 HHHHHHHHHHHHHHHHHHH...TTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHHHH CS
     Pkinase  98 eeakkiakqilegleylHs...kgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvl..keneyskkvDvWslGvilyel 190
                  +  +i++ +++g+ ylHs   ++iiHrDlK +NiL+d++ + K++DFGl+k ++ +s  +t+ vgt  Y+APE+l  ++++ ++k+Dv+s G+il+el
  EFC37179.1 751 VTKLNILNDVCKGMVYLHSirpNKIIHRDLKCANILLDKNMNAKVGDFGLSKIVNGNSAtMTTNVGTLLYIAPELLsnHHRGPTTKIDVYSFGIILWEL 849
                 56679*************833356**************999**************99888****************5444555**************** PP

                 HHSS-STTTSSHH.HHHHHHHHTHHHHHHHCT....SHH...HHHTTS................-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 191 ltgkppfsgekgk.ekvekeldqlekilkilg....etkeklpeasei................seeakdllkkllkkdpkkRltaeell 259
                 l++  pfs+e ++ ++v ++l++   ++k  +    +t++++ e++ i                 ++ ++++k++++ +p++R+ + ++ 
  EFC37179.1 850 LYEMVPFSDELSDtNTVFSILME---VIKGHRpriiTTDQAWIENN-IskkeidkygisklelsLSDYIEIMKECWNNEPNQRPEFIQVA 935
                 ********554330333344444...33333344432233332222.257778999*******9899*****************987765 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  173.7   0.1   9.6e-55   4.3e-51       2     259 .]     657     938 ..     656     938 .. 0.91

  Alignments for each domain:
  == domain 1  score: 173.7 bits;  conditional E-value: 9.6e-55
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ek 97 
                  ++ kk+GeGa G V++g ++      +++Va+K++k ++++e   e+ +ea +m++l+hp iv+++g+ +++e+ ++++ey+++G L+  + ++   k
   EFC37179.1 657 TIVKKIGEGASGVVYKGLWN------KTDVAIKQFKTDTDDE---EFEREALLMSSLRHPSIVSCYGISLSTESKYMIVEYLSNGALDGAIYESkiGK 745
                  6889****************......9********8877776...9*******************************************999985679 PP

                  TTSBHHHHHHHHHHHHHHHHHHHH...TTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..EEHHHHHHH CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLes...kklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk..ftsksDvWs 190
                  +kl++ ++l++  +v+kGm yL+s   +k++Hrdl + N+Ll++n+ +k++DfGL++ +  + +  + +++   + ++apE l++++   t+k Dv+s
   EFC37179.1 746 KKLSYVTKLNILNDVCKGMVYLHSirpNKIIHRDLKCANILLDKNMNAKVGDFGLSKIV--NGNSATMTTNVGTLLYIAPELLSNHHrgPTTKIDVYS 841
                  9**********************944456****************************99..555666677788999*******9998779******** PP

                  HHHHHHHHHTTSSGT.............................TTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 191 fGvllwEiftlgesp.............................ypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                  fG++lwE++     p                              + + ++++ +k  +++ ++k e   ++  e+mk+cw+++p++Rp+f ++ e l
   EFC37179.1 842 FGIILWELLY-EMVPfsdelsdtntvfsilmevikghrpriittDQAWIENNISKKEIDKYGISKLELSLSDYIEIMKECWNNEPNQRPEFIQVAESL 938
                  ********99.456678999*****************999998655568888899999999*******************************998876 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   9.9e-06     0.044     308     392 ..     753     831 ..     742     851 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 9.9e-06
  Pkinase_fungal 308 llealrDaIkghrsLfl..kagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHs 392
                      l+ l D+ kg   L++    +i+HrD    Nil+      ++ +  + D+ l k ++ +  ++   + +GTl ++a e+l+ ++H+
      EFC37179.1 753 KLNILNDVCKGMVYLHSirPNKIIHRDLKCANILLD-----KNMNAKVGDFGLSKIVNGN--SATMTTNVGTLLYIAPELLS-NHHR 831
                     5788999999999998422579*************9.....66788899*********63..444579*************9.4453 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.2     0.013        58       1      11 [.     247     257 ..     247     302 .. 0.87
   2 ?    7.3   0.6    0.0017       7.5       1      25 [.     330     344 ..     330     347 .. 0.89
   3 ?   11.0   0.6   0.00011       0.5       1      26 [.     356     371 ..     356     372 .. 0.95
   4 ?   -1.9   0.3       1.4   6.1e+03       4      11 ..     804     811 ..     803     818 .. 0.70

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.013
   Chlam_PMP   1 sitFsnNtatv 11 
                 ++tF+nNt+t+
  EFC37179.1 247 NCTFNNNTGTI 257
                 69******976 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0017
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAI 25 
                 ++ FsnN a            GGAI
  EFC37179.1 330 NCFFSNNVA----------EFGGAI 344
                 578******..........9****9 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00011
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAIy 26 
                 +++F +N a          ++GGAIy
  EFC37179.1 356 NCSFIGNEA----------KKGGAIY 371
                 689******..........******9 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 1.4
   Chlam_PMP   4 FsnNtatv 11 
                 +++N+at 
  EFC37179.1 804 VNGNSATM 811
                 689***54 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (947 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       791  (0.0441185); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.25s 00:00:00.82 Elapsed: 00:00:00.42
# Mc/sec: 6709.86
//
Query:       EFC37180.1  [L=248]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.1e-18   66.2   1.8    3.1e-18   66.2   1.8    2.7  2  HEPN_Swt1       Swt1-like HEPN
     0.0057   16.6   0.2     0.0057   16.6   0.2    1.9  2  HEPN_RiboL-PSP  RiboL-PSP-HEPN
  ------ inclusion threshold ------
      0.012   16.5   0.1      0.048   14.5   0.0    2.0  2  CTD_bind        RNA polymerase II-binding domain.
       0.22   11.6   2.4       0.44   10.6   2.4    1.5  1  MAS20           MAS20 protein import receptor
        1.9    7.2   4.3        2.2    6.9   4.3    1.1  1  Presenilin      Presenilin


Domain annotation for each model (and alignments):
>> HEPN_Swt1  Swt1-like HEPN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.2   1.8   8.7e-22   3.1e-18      11     115 ..      22     148 ..      15     149 .. 0.87
   2 ?   -0.2   0.8      0.35   1.3e+03      29      46 ..     184     198 ..     158     232 .. 0.49

  Alignments for each domain:
  == domain 1  score: 66.2 bits;  conditional E-value: 8.7e-22
   HEPN_Swt1  11 rpfverelskaygedwweeveaslekdeeek...................kesekeiskldvqdllrvitenWkevFkk...klsraerslaseLrevR 87 
                 +p+v+ +ls++yge+w e ve++++++ + +                   + + +  s++d+q+ + vi+++W+++F      l++++r+l  e r+ R
  EFC37180.1  22 EPLVKTALSEEYGEGWKEIVEKAASNQDQGGdymsattfgrgssssaprfNVNLSASSAWDTQNIIGVIQRHWNDAFAAgnrWLTNTDRNLLFEARNCR 120
                 699******************95543333335777778888888888888888999*********************765559**************** PP

   HEPN_Swt1  88 NkwaHqesfstddayraldtierllrai 115
                 NkwaHq+ f+ +d+yr +d+i+rll+ i
  EFC37180.1 121 NKWAHQNHFTLRDTYRYIDSIQRLLELI 148
                 *************************987 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.35
   HEPN_Swt1  29 eveaslekdeeekkesek 46 
                 + ++   +++ ++++s+k
  EFC37180.1 184 KHAK---SSKPSSSSSSK 198
                 2221...22222222222 PP

>> HEPN_RiboL-PSP  RiboL-PSP-HEPN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.2   1.6e-06    0.0057      80     190 ..       9     150 ..       2     154 .. 0.71
   2 ?   -1.2   0.7      0.46   1.7e+03      88      89 ..     195     196 ..     152     234 .. 0.43

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.6e-06
  HEPN_RiboL-PSP  80 salklldwkkknpkkeiikelfklfgenisekinkafidtesnlkskvleeifk........rlglekskkeskk.................... 146
                     ++l++ ++ ++++ + +   l++++ge ++e+++k   ++ +   +  +  +f         r++++ s  + ++                    
      EFC37180.1   9 ETLDQQKYFNRIYEPLVKTALSEEYGEGWKEIVEK-AASNQDQGGDYMSATTFGrgssssapRFNVNLSASSAWDtqniigviqrhwndafaagn 102
                     55555555666666666666688888888888888.22222222222333333366666666555555555555555889999999999999999 PP

  HEPN_RiboL-PSP 147 ........kklnelvkrRNeIAHgndsdtdltkdeleeyidfikelvealde 190
                             + l e  ++RN+ AH+n +    t ++ + yid i+ l+e + e
      EFC37180.1 103 rwltntdrNLLFEARNCRNKWAHQNHF----TLRDTYRYIDSIQRLLELIPE 150
                     99999999***************9999....***************999876 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.46
  HEPN_RiboL-PSP  88 kk 89 
                      +
      EFC37180.1 195 SS 196
                     22 PP

>> CTD_bind  RNA polymerase II-binding domain.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       2.2   7.8e+03      21      21 ..      31      31 ..       6      50 .. 0.54
   2 ?   14.5   0.0   1.3e-05     0.048       4      43 ..     166     205 ..     165     214 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.2
    CTD_bind 21 d 21
                +
  EFC37180.1 31 E 31
                2 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 1.3e-05
    CTD_bind   4 llYLaNdvlqnskrkqkdefapaFapvlpeafadaykkap 43 
                 llYLaN+v + sk+kq+++ a++ +p   +  +++ +++p
  EFC37180.1 166 LLYLANEVKRESKKKQEEKHAKSSKPSSSSSSKNVSHSSP 205
                 8***************998888888877777777766544 PP

>> MAS20  MAS20 protein import receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   2.4   0.00012      0.44      28      92 ..     172     236 ..     160     241 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00012
       MAS20  28 klrerrkkqakaakeeeeaekaekkkkealeeakee.lptdaeevekfFleevqlGEellaqgeee 92 
                 ++++++kk++++ k++++++ +++++++ +++   e   +++ee e+++ ++++   +l+++    
  EFC37180.1 172 EVKRESKKKQEE-KHAKSSKPSSSSSSKNVSHSSPEyHEEEQEEEEEYYNSNISYNSSLFQSTATT 236
                 455555555533.23333333333334456666666567999***********9988888876555 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   4.3   0.00063       2.2     222     316 ..     174     215 ..     105     246 .. 0.51

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00063
  Presenilin 222 vlaaeekkaevaeseeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaeesseekeseessesseeeeeeeeeeeese 316
                                                                        e+++++e+++++ss++++s++s++ s+++ e +eee+e+e
  EFC37180.1 174 KR-----------------------------------------------------ESKKKQEEKHAKSSKPSSSSSSKNVSHSSPEYHEEEQEEE 215
                 11.....................................................1111111111111111111111111111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (248 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2326  (0.129734); expected 358.6 (0.02)
Passed bias filter:                      773  (0.0431145); expected 358.6 (0.02)
Passed Vit filter:                       119  (0.00663729); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.45u 0.25s 00:00:00.70 Elapsed: 00:00:00.40
# Mc/sec: 1882.82
//
Query:       EFC37181.1  [L=691]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      2e-73  241.9  18.1    8.3e-13   47.8   0.2    9.8 10  DUF4116      Domain of unknown function (DUF4116)
    1.4e-17   64.0   0.6    7.6e-17   61.5   0.6    2.2  1  Pkinase      Protein kinase domain
    8.9e-11   41.5   0.1    0.00037   19.9   0.1    2.3  2  Pkinase_Tyr  Protein tyrosine kinase
  ------ inclusion threshold ------
       0.01   16.2   0.1      0.019   15.3   0.1    1.4  1  PMEI         Plant invertase/pectin methylesterase inhibitor
        2.9    8.0  14.8        2.7    8.1   0.9    4.3  4  Mei5_like    Putative double-strand recombination repair-like


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.1   0.00093       3.4       4      35 ..     243     281 ..     241     290 .. 0.69
   2 !   35.9   0.0   1.3e-12   4.5e-09       1      44 [.     301     341 ..     301     346 .. 0.96
   3 !   24.2   0.1   5.6e-09     2e-05       1      40 [.     349     388 ..     349     390 .. 0.93
   4 !    8.8   2.8   0.00037       1.3       1      42 [.     374     415 ..     374     449 .. 0.90
   5 !   47.8   0.2   2.3e-16   8.3e-13       1      49 []     495     543 ..     495     543 .. 0.98
   6 !   46.7   0.0   5.2e-16   1.9e-12       1      49 []     520     568 ..     520     568 .. 0.97
   7 !   39.8   0.0   7.5e-14   2.7e-10       1      48 [.     545     592 ..     545     593 .. 0.97
   8 !   44.7   0.0   2.2e-15     8e-12       1      49 []     570     618 ..     570     618 .. 0.96
   9 !   41.3   0.2   2.6e-14   9.3e-11       1      47 [.     595     641 ..     595     643 .. 0.96
  10 !   24.2   0.6   5.5e-09     2e-05       1      43 [.     645     688 ..     645     690 .. 0.94

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00093
     DUF4116   4 ivleavkkngs......alky.lseeLknDkeivlkAvk 35 
                 i   ++k+ng+      ++   ++++++++++i+l+++ 
  EFC37181.1 243 ILSRIFKTNGLssdffkSYPIgINDNFTHNRDIILACLS 281
                 55566777777343333222247899***********86 PP

  == domain 2  score: 35.9 bits;  conditional E-value: 1.3e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 Dr++++++v + g+ lky++e    D+eivl+Av+ +gt+l y+
  EFC37181.1 301 DRQFIMQVVNRKGYLLKYINEI---DREIVLEAVREDGTSLAYV 341
                 9*******************87...****************998 PP

  == domain 3  score: 24.2 bits;  conditional E-value: 5.6e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 DrEi+  a+++n +a+  ++++Lk+D +i+   v++ + +
  EFC37181.1 349 DREIIETAIQQNANAYFEIDSSLKHDEQIIQLTVERFKLS 388
                 9*****************************9999987765 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.00037
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 D++i+   v+++ ++l+ + e+LknD+e  lk ++q g+ l+
  EFC37181.1 374 DEQIIQLTVERFKLSLQACVESLKNDIENNLKVIEQLGIELK 415
                 788888999************************999777665 PP

  == domain 5  score: 47.8 bits;  conditional E-value: 2.3e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+vle++kk+  +++ ++e ++nDk ++l+ vkq gtal+y+se+++
  EFC37181.1 495 DKELVLEVIKKFRPSIQQADELIRNDKKFILETVKQKGTALEYVSEDFK 543
                 9*********************************************986 PP

  == domain 6  score: 46.7 bits;  conditional E-value: 5.2e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+ ++le vk+ g al+y+se++knD +i+++Av +n +al y++e+++
  EFC37181.1 520 DKKFILETVKQKGTALEYVSEDFKNDPDIIKAAVGNNVHALTYVDESWK 568
                 999******************************************9875 PP

  == domain 7  score: 39.8 bits;  conditional E-value: 7.5e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D +i++ av +n  al+y++e++k+D+++vl+ v+++g al+y+++++
  EFC37181.1 545 DPDIIKAAVGNNVHALTYVDESWKKDRDFVLQLVEIDGAALEYVDPKF 592
                 89******************************************9987 PP

  == domain 8  score: 44.7 bits;  conditional E-value: 2.2e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr++vl++v+++g al+y+++++++D+eiv+ A++++g++l  ++ +L+
  EFC37181.1 570 DRDFVLQLVEIDGAALEYVDPKFQKDREIVKIALQNDGFVLFSLDSSLQ 618
                 9****************************************99988775 PP

  == domain 9  score: 41.3 bits;  conditional E-value: 2.6e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 DrEiv+ a++++g++l  l+++L+ Dkeiv++Av qn  +l+y++ +
  EFC37181.1 595 DREIVKIALQNDGFVLFSLDSSLQMDKEIVIEAVIQNVLVLEYIDVS 641
                 9******************************************9865 PP

  == domain 10  score: 24.2 bits;  conditional E-value: 5.5e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsy 43 
                 D+ +++e+ + + +al+++++ LknD ++ l+ ++ +g t+l++
  EFC37181.1 645 DKSFMKEVAQYDEYALYFADDLLKNDSDFKLEMLNEYGeTVLEF 688
                 899***********************************778887 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.5   0.6   2.1e-20   7.6e-17      59     261 ..       5     246 ..       1     248 [. 0.69

  Alignments for each domain:
  == domain 1  score: 61.5 bits;  conditional E-value: 2.1e-20
                 TB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET...........TTEEEE-SGTTSE CS
     Pkinase  59 nivrlyevfeekdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide...........kgelKitDFGlak 146
                 ni+++  + ++ +e +++  y +g +l ++ + k +l   ++ +i+ ++ +gl+ lH++++iH+D+Kp+N++++e           + e  i+D+G ++
  EFC37181.1   5 NILTYEITEKNGNEAIIISKY-RGINLSNYRNLKPKLYLGNLLQILIKTSHGLKSLHDNNLIHCDIKPDNLFLQEtiitkkednilHIETIIGDLGSVR 102
                 455444444444445555555.55668888887788888899999*****************************8789887666662225666666666 PP

                 ESSSSCS...........................BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHH CS
     Pkinase 147 elesssk...........................ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilk 218
                 e     +                            + ++gt  ++APE l++  +s  +D+WslG  l+++++ k+         +++++ld++ + l 
  EFC37181.1 103 ENACPIPsdrigvtvtkvqdvdsnpsnlsessssSSFICGTFGFIAPECLNQGLISFRSDIWSLGRSLLNVIFPKNES------LDIQHHLDDIYQYLI 195
                 65555445566666666666666666666666668888************99999************99995544433......345555555333333 PP

                 HCT........SHH...HHHTTS........-HHHHHHHHHHT-SSGCCSTTHHHHHTS CS
     Pkinase 219 ilg........etkeklpeasei........seeakdllkkllkkdpkkRltaeellqh 261
                 i           ++                   e+ ++l ++l+ d + R+ a+e+l+ 
  EFC37181.1 196 IHMennnisqiIKE--------AnldddiegWTEFFKILISMLNDDYEMRPNASEILSR 246
                 33212222212122........133555566899999******************9975 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.1     1e-07   0.00037      67     145 ..       9      85 ..       1     109 [. 0.79
   2 !   19.4   0.0   1.4e-07   0.00052     170     258 ..     145     246 ..     123     247 .. 0.84

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 1e-07
                  EEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE- CS
  Pkinase_Tyr  67 lgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkis 145
                  + +  k+++  i++   +g +L+++ +   k+kl l +ll++ ++ ++G++ L++++l+H d+   N +l+e+ + k  
   EFC37181.1   9 YEITEKNGNEAIIISKYRGINLSNYRNL--KPKLYLGNLLQILIKTSHGLKSLHDNNLIHCDIKPDNLFLQETIITKKE 85 
                  4444555666666666678899999555..69***************************************98776654 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 1.4e-07
                  GGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGT..............TTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HH CS
  Pkinase_Tyr 170 kWmapEslkekkftsksDvWsfGvllwEiftlgesp..............ypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfs 253
                   ++apE+l+++ ++ +sD+Ws G  l  ++   +++              + +++n++ ++++ ++ +l+   + ++e+ +++ + ++ d e Rp+ s
   EFC37181.1 145 GFIAPECLNQGLISFRSDIWSLGRSLLNVIFPKNESldiqhhlddiyqylIIHMENNN-ISQIIKEANLDDDIEGWTEFFKILISMLNDDYEMRPNAS 241
                  589*********************99999886666689999****9886555666666.5666666778888889999*******************9 PP

                  HHHHH CS
  Pkinase_Tyr 254 elvek 258
                  e++++
   EFC37181.1 242 EILSR 246
                  99875 PP

>> PMEI  Plant invertase/pectin methylesterase inhibitor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.3   0.1   5.2e-06     0.019      70     147 ..     380     479 ..     339     484 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 5.2e-06
                 H......HHHHHHHHHHHHHHHHHHHHHHHHH.........-HH.....HHHHHHHHHHHHHHHHHHHHTTS........S--.....HH.HHHHHHHH CS
        PMEI  70 k......aaledClelyedavdeLedalaalk.........rskrk.vddaqtwlsaaltdqdtCedgfkea........kkalkkkvksplaaenrel 144
                          l+ C+e +++ +++  +++++l          +   k  + ++  l  al++ d Ce+ f e         +++l k++++   a+n+ +
  EFC37181.1 380 LtverfkLSLQACVESLKNDIENNLKVIEQLGielkkirnrEFIMKqFSHVEEALQIALSNLDFCENDFTENieeifetsRDTLVKSINE--FAQNDFI 476
                 0233356789********999975557777777788887886666777999******************988877766554444444444..4455555 PP

                 HHH CS
        PMEI 145 kql 147
                 ++l
  EFC37181.1 477 EEL 479
                 555 PP

>> Mei5_like  Putative double-strand recombination repair-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.1    0.0042        15      67      98 ..     208     239 ..     179     254 .. 0.85
   2 ?   -2.5   0.1       1.4     5e+03      58      80 ..     298     320 ..     270     330 .. 0.56
   3 ?    8.1   0.9   0.00074       2.7      62     101 ..     369     408 ..     344     423 .. 0.78
   4 ?    1.8   0.6     0.067   2.4e+02      45      86 ..     487     528 ..     445     542 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0042
   Mei5_like  67 knkdleeliekwkevieeciiiLkkefelkak 98 
                 k+ +l++ ie w e  +  i++L++ +e++++
  EFC37181.1 208 KEANLDDDIEGWTEFFKILISMLNDDYEMRPN 239
                 6789************************9874 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.4
   Mei5_like  58 Lkliekfkkknkdleeliekwke 80 
                 L++ ++f  +  + +    k+ +
  EFC37181.1 298 LRMDRQFIMQVVNRKGYLLKYIN 320
                 44444444444444444444433 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.00074
   Mei5_like  62 ekfkkknkdleeliekwkevieeciiiLkkefelkakevf 101
                   +k++++ ++  +e++k +++ c++ Lk+  e + k + 
  EFC37181.1 369 SSLKHDEQIIQLTVERFKLSLQACVESLKNDIENNLKVIE 408
                 567889999999******************9998877664 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.067
   Mei5_like  45 kdplfiekdiyrKLkliekfkkknkdleeliekwkevieeci 86 
                 + p++ + d+   L +i+kf+   ++ +eli   k+ i e++
  EFC37181.1 487 RAPNYYKNDKELVLEVIKKFRPSIQQADELIRNDKKFILETV 528
                 466777778888888888888888888888888777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (691 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       828  (0.0461822); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 4268.59
//
Query:       EFC37182.1  [L=294]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0099   16.2   0.7      0.024   14.9   0.7    1.8  1  SirA          Sporulation inhibitor of replication protein Si
  ------ inclusion threshold ------
        3.3    7.5   9.1        7.7    6.4   9.1    1.6  1  Adeno_E3_CR2  Adenovirus E3 region protein CR2


Domain annotation for each model (and alignments):
>> SirA  Sporulation inhibitor of replication protein SirA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.7   2.7e-06     0.024      79     132 ..      86     140 ..      52     147 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.7e-06
                 EEE-GGGSEEEEEEEETTEEEEEEEESTHH.HHHHHHHHHH-TTEEEEETTTTEE CS
        SirA  79 vinnlkkeevaeltiknsyikletegnyea.tiffevLrkvnpnffvcDfenkdY 132
                  ++++  +++++lt+kns+i+le e+++   t+f++   + +  f   D+++k Y
  EFC37182.1  86 AYQTQLTNNCTQLTLKNSFIELEFEQSERYpTTFCDEFVEKKDWFVTEDMQHKFY 140
                 344445689*****************************99666666667777665 PP

>> Adeno_E3_CR2  Adenovirus E3 region protein CR2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   9.1   0.00086       7.7       4      34 ..     254     290 ..     252     292 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.00086
  Adeno_E3_CR2   4 stiaIivaVvvGlaiIiicm......lyYaCcYrkhr 34 
                   s i+Iiv+ ++G + +iic+      l+Y ++++k +
    EFC37182.1 254 SDIGIIVGATIGGLFVIICFsvsiigLLYMFYRKKQY 290
                   679*********9999999977767778999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (294 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       893  (0.0498076); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1869.41
//
Query:       EFC37183.1  [L=831]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (831 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       651  (0.0363099); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.47
# Mc/sec: 5371.14
//
Query:       EFC37184.1  [L=827]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.092   12.6   0.4       0.24   11.3   0.4    1.7  1  Cas_APE2256  CRISPR-associated protein (Cas_APE2256)


Domain annotation for each model (and alignments):
>> Cas_APE2256  CRISPR-associated protein (Cas_APE2256)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.4   1.4e-05      0.24      24     123 ..     707     811 ..     691     816 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.4e-05
  Cas_APE2256  24 elvllssdTaaGklvaeilkeylee...egaevevveieklsdlg.reeFreglrnLveklarevknkkregek.vlinaTgGfKpeiavltlvall. 115
                  +  + ++  ++ + + ++ +e+++e   + +++++++   +++ + + +F++ l n  e++++ v+ k+   +     n+T G+Kp +++++ va l 
   EFC37184.1 707 KSNYSATQQHKVREIIDVQNEWIDEcdtSFNNYQTYNSTPVNKGQiKFTFKRFLMNEGEAIKTNVQYKEITKYWfQRRNLT-GYKPSSVIIVSVAILf 803
                  5566677777888888899999999886666699999999**9997888*****************544444432334666.8**************8 PP

  Cas_APE2256 116 ladevyYi 123
                   a  +yY+
   EFC37184.1 804 IALLIYYK 811
                  99999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (827 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1191  (0.0664287); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 4851.89
//
Query:       EFC37185.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.071   12.2   0.1      0.072   12.2   0.1    1.1  1  ABC2_membrane_3  ABC-2 family transporter protein
       0.16   12.1   0.4       0.27   11.3   0.4    1.3  1  Internalin_N     Bacterial adhesion/invasion protein N termin


Domain annotation for each model (and alignments):
>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1     8e-06     0.072       1      76 [.       3      77 ..       3     117 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 8e-06
  ABC2_membrane_3  1 ksfliitlllPiilvlllglifsnsveddentpiavvdedn...sslsqqlvealea.spsve.lvyevdseeeakkalkn 76
                     k+fl+++lll  ++++ +++   ++++ ++  ++a++d +    +       + l++ + s+e ++++ + eee + al++
       EFC37185.1  3 KRFLVFSLLLLTLFLISGFFSTTSTSNVVSAESVALLDGTEeemT------LDSLDTaEASTEsNTENSEGEEEEEAALEQ 77
                     68888877766666655555555566689*********9963330......222222122333323333334444444433 PP

>> Internalin_N  Bacterial adhesion/invasion protein N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.4     3e-05      0.27      10      38 ..      10      37 ..       2      38 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3e-05
                  XXXXXXXXXXXXXXXXXXXXXXXGSXS-S CS
  Internalin_N 10 lltvtlvLllsllvltsnGekvqAeasit 38
                  ll +tl+L+ ++  +ts+ + v+Ae s++
    EFC37185.1 10 LLLLTLFLISGFFSTTSTSNVVSAE-SVA 37
                  8899*********************.875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1468  (0.0818785); expected 358.6 (0.02)
Passed bias filter:                      716  (0.0399353); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.43
# Mc/sec: 894.90
//
Query:       EFC37186.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.01   15.6   1.8      0.016   15.0   1.8    1.4  1  CbtA             Probable cobalt transporter subunit (CbtA)
        2.3    8.5  16.1        7.5    6.9  14.1    2.5  2  DUF4064          Protein of unknown function (DUF4064)
          3    7.7   6.4        8.1    6.3   6.4    1.8  1  DUF5134          Domain of unknown function (DUF5134)
        3.7    7.6   9.8        5.9    7.0   9.8    1.3  1  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe


Domain annotation for each model (and alignments):
>> CbtA  Probable cobalt transporter subunit (CbtA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   1.8   3.5e-06     0.016      42     120 ..       4      94 ..       1     115 [. 0.75

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 3.5e-06
        CbtA  42 aaaeaaeaaaeHeh............aeaeepe......lvsrgvqrtlgtvlanvltgvalglllaavfallegrlgklsaralalllalagflav 120
                 +++++ + +++H h            +            ++ +gv +  ++++a  ++++a+g+l+aa +a++ ++ ++ s+  + ++l+++g + +
  EFC37186.1   4 HHHHGRHGHHHHHHvnhhvgggivigN-----RrtkplaTIISGVVSI-LIGIALGIAAIAVGALYAACLAVTTNSSTSCSGITTPIVLGVIGIVLI 94 
                 333333333323335555556666552.....0333445888888888.99*************************999999999999999997765 PP

>> DUF4064  Protein of unknown function (DUF4064)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9  14.1    0.0017       7.5       5      80 ..      34     102 ..      30     113 .. 0.66
   2 ?    6.8   5.1    0.0018         8       3      42 ..      81     122 ..      79     156 .. 0.56

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0017
     DUF4064   5 eiiLglIGgilgillglllllflfllssgefsqelteeqalsgedasavleflstllivlgvialiaivlgivgal 80 
                   + ++I+g+++il+g++l+++++ +++ + +        l+++ +s+++ +  t+ ivlgvi++++i++gi +++
  EFC37186.1  34 KPLATIISGVVSILIGIALGIAAIAVGALYAA-------CLAVTTNSSTSCSGITTPIVLGVIGIVLIIAGISSVI 102
                 55668*****************9999776544.......3445555555555555556666666666666654443 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0018
     DUF4064   3 kaeiiLglIGgil..gillglllllflfllssgefsqeltee 42 
                 ++ i+Lg+IG++l    ++++++++ +f+++++  +     +
  EFC37186.1  81 TTPIVLGVIGIVLiiAGISSVIAGIRMFIIMKNIADGMSRSD 122
                 677888888875411445666666666666666655443333 PP

>> DUF5134  Domain of unknown function (DUF5134)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   6.4    0.0018       8.1      80     126 ..       5      71 ..       1     150 [. 0.66

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0018
     DUF5134  80 alaaggghsghaaagasmpgg...............vplvtgvlavyFaaaalvwlarllp.....a 126
                 ++++++gh++h++ +++  gg                 +v++++ +++ +aa++++a + +     +
  EFC37186.1   5 HHHGRHGHHHHHHVNHHVGGGivignrrtkplatiiSGVVSILIGIALGIAAIAVGALYAAclavtT 71 
                 3555566666666666666668*******88888864444555555555555555543333333330 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   9.8    0.0013       5.9      34      90 ..      42     100 ..      37     129 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0013
  Phage_holin_3_6  34 gsgagllgaagvlallalllllvalalala.alwlaaliva.avllvlagvlalvglkk 90 
                      g+  +l+g+a+ +a++a+++l +a++++ +  +  +  i++ +vl v+++vl+++g++ 
       EFC37186.1  42 GVVSILIGIALGIAAIAVGALYAACLAVTTnSSTSCSGITTpIVLGVIGIVLIIAGISS 100
                      56678999999999999999999997555433444444433255555555555555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1248  (0.0696079); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1565.65
//
Query:       EFC37187.1  [L=515]
Description: hypothetical protein NAEGRDRAFT_53913 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-06   28.5  43.4    8.2e-05   22.9   3.4    8.3  8  LRR_4       Leucine Rich repeats (2 copies)
    9.7e-06   25.3   0.2    2.6e-05   23.9   0.2    1.7  1  F-box       F-box domain
     0.0036   17.1   0.1     0.0088   15.9   0.1    1.6  1  F-box-like  F-box-like
  ------ inclusion threshold ------
       0.23   11.6  13.1         17    5.8   0.3    6.4  6  LRR_6       Leucine Rich repeat
        2.7    7.8  22.8       0.89    9.4   0.5    5.9  6  LRR_8       Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.14     5e+02      19      41 ..     148     168 ..     136     171 .. 0.64
   2 !   14.3   1.0   1.1e-05      0.04       1      37 [.     151     192 ..     151     199 .. 0.83
   3 !   16.3   2.2   2.8e-06    0.0099       2      35 ..     178     212 ..     177     219 .. 0.76
   4 ?   -1.7   0.0       1.2   4.4e+03       4      28 ..     234     260 ..     231     261 .. 0.54
   5 !   22.9   3.4   2.3e-08   8.2e-05       1      39 [.     281     316 ..     281     325 .. 0.84
   6 ?    0.1   0.5      0.33   1.2e+03      19      28 ..     328     336 ..     314     345 .. 0.71
   7 ?    0.3   0.2       0.3   1.1e+03      10      30 ..     352     371 ..     349     384 .. 0.64
   8 ?   -7.6  14.7         5   1.8e+04       2      27 ..     415     430 ..     364     475 .. 0.67

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.14
                 HHH-TT--EEE-.-S-----GGG CS
       LRR_4  19 leklpnLkeLdLsgNnlitdlde 41 
                 ++ ++n ++L Lsg  l++++ +
  EFC37187.1 148 PQ-IKNVTSLKLSGA-LVSSFQS 168
                 33.888888888776.5555554 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1.1e-05
                 SS--EEE--SS---E-S-HH....H-TT--EEE-.-S---.- CS
       LRR_4   1 pnLevLdLsnNqltdiplle....klpnLkeLdLsgNnli.t 37 
                 +n ++L Ls+  ++++++l+      ++L++Ld+sgNnli +
  EFC37187.1 151 KNVTSLKLSGALVSSFQSLSrkgiRWDKLHTLDISGNNLIlS 192
                 6999******99******6667655899**********9954 PP

  == domain 3  score: 16.3 bits;  conditional E-value: 2.8e-06
                 S--EEE--.SS-.--E-S-HH..H-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLs.nNq.ltdiplle..klpnLkeLdLsgNnl 35 
                 +L +Ld+s nN  l+++  l   ++pnL+eL+L +  +
  EFC37187.1 178 KLHTLDISgNNLiLSSVKHLTkcQMPNLTELSL-R--Q 212
                 79******5554455777788888********9.5..3 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 1.2
                 -EEE--SS---E-S-.HH.H.-TT--EE CS
       LRR_4   4 evLdLsnNqltdipl.le.k.lpnLkeL 28 
                 ++Ld s  +   i++ l+ k l++ ++L
  EFC37187.1 234 KKLDVSY-NFDGIGScLGtKyLKQITHL 260
                 5677775.45555554334335555555 PP

  == domain 5  score: 22.9 bits;  conditional E-value: 2.3e-08
                 SS--EEE--SS---E-S-HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipllek.lpnLkeLdLsgNnlitdl 39 
                 pnLe+Ld++n q+tdi+l ++ ++nL++L ++++    ++
  EFC37187.1 281 PNLEYLDIGNYQITDISLSNGnCKNLTYLKITEC----SI 316
                 8********77*******9966********9766....33 PP

  == domain 6  score: 0.1 bits;  conditional E-value: 0.33
                 HHH-TT--EE CS
       LRR_4  19 leklpnLkeL 28 
                 + +lpnL+++
  EFC37187.1 328 P-NLPNLTTV 336
                 4.4****997 PP

  == domain 7  score: 0.3 bits;  conditional E-value: 0.3
                 SS---E-S-HHH-TT--EEE- CS
       LRR_4  10 nNqltdiplleklpnLkeLdL 30 
                 +N + ++p+ +   + + L L
  EFC37187.1 352 DNTIAKFPPNS-QSSITNLKL 371
                 78899877744.667777777 PP

  == domain 8  score: -7.6 bits;  conditional E-value: 5
                 S--EEE--.SS-.--E-S-HHH-TT--E CS
       LRR_4   2 nLevLdLs.nNq.ltdiplleklpnLke 27 
                 nLe+L++  +N+ l+             
  EFC37187.1 415 NLEYLSIDgGNKeLQ------------I 430
                 444444443332222............2 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.2   7.4e-09   2.6e-05       5      41 ..      96     132 ..      93     135 .. 0.94

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 7.4e-09
                 HS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHH CS
       F-box   5 rLPsevlrhILerLplsdllalrrVSkgwrilidsdr 41 
                 rL s+ l  I+++L+  dl  +r VSk w++++d+++
  EFC37187.1  96 RLNSDNLFSIFQFLNVNDLAYCRYVSKLWKDVVDRVE 132
                 99********************************975 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.1   2.5e-06    0.0088       9      36 ..     102     129 ..      99     132 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 2.5e-06
  F-box-like   9 LlqIFsyLppsdLlrlalVCrrWrrval 36 
                 L  IF++L+ +dL+ ++ V++ W++v+ 
  EFC37187.1 102 LFSIFQFLNVNDLAYCRYVSKLWKDVVD 129
                 789***********************94 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.1   1.1e+04       4      12 ..     152     160 ..     151     161 .. 0.82
   2 ?    5.8   0.3    0.0046        17       4      15 ..     178     189 ..     178     190 .. 0.88
   3 ?   -0.1   0.0      0.37   1.3e+03       3      11 ..     203     211 ..     201     214 .. 0.84
   4 ?    3.1   0.0     0.035   1.2e+02       3      13 ..     231     241 ..     230     241 .. 0.92
   5 ?    1.4   0.0      0.12   4.3e+02       2      17 ..     280     295 ..     279     299 .. 0.79
   6 ?    3.4   0.5     0.027        98       1      17 [.     302     318 ..     302     320 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.1
       LRR_6   4 hLteLdLsg 12 
                 ++t+L Lsg
  EFC37187.1 152 NVTSLKLSG 160
                 689999996 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0046
       LRR_6   4 hLteLdLsgNdI 15 
                 +L +Ld+sgN++
  EFC37187.1 178 KLHTLDISGNNL 189
                 599*******95 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.37
       LRR_6   3 thLteLdLs 11 
                 ++LteL+L+
  EFC37187.1 203 PNLTELSLR 211
                 79*****97 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.035
       LRR_6   3 thLteLdLsgN 13 
                 +++++Ld+s+N
  EFC37187.1 231 STVKKLDVSYN 241
                 799*******9 PP

  == domain 5  score: 1.4 bits;  conditional E-value: 0.12
       LRR_6   2 nthLteLdLsgNdIgD 17 
                 +++L++Ld+   +I+D
  EFC37187.1 280 KPNLEYLDIGNYQITD 295
                 689*****98777776 PP

  == domain 6  score: 3.4 bits;  conditional E-value: 0.027
       LRR_6   1 snthLteLdLsgNdIgD 17 
                 ++ +Lt+L ++ + I++
  EFC37187.1 302 NCKNLTYLKITECSINN 318
                 689**********9987 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   2.0    0.0024       8.6       2      33 ..     178     211 ..     151     216 .. 0.59
   2 ?    6.3   1.5    0.0022       7.8       2      34 ..     178     212 ..     177     241 .. 0.80
   3 ?    9.4   0.5   0.00025      0.89      19      59 ..     275     314 ..     270     318 .. 0.76
   4 ?    1.4   0.0     0.075   2.7e+02      25      57 ..     364     395 ..     354     398 .. 0.83
   5 ?    0.3   0.3      0.17   6.1e+02      46      58 ..     411     423 ..     400     426 .. 0.66
   6 ?   -0.2   0.3      0.24   8.7e+02       2      30 ..     439     467 ..     437     488 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0024
                 T-SEEE-TTS-..-SEE-TTSSTT-TT--EEE-- CS
       LRR_8   2 nLtsLdLsnNr..ltslddeaFkglsnLkvLdLs 33 
                 +L++Ld+s N+  l+s++  +  +++nL++L+L+
  EFC37187.1 178 KLHTLDISGNNliLSSVKHLTKCQMPNLTELSLR 211
                 3555555555543344444444445555555554 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0022
                 T-SEEE-TTS-..-SEE-TTSSTT-TT--EEE--S CS
       LRR_8   2 nLtsLdLsnNr..ltslddeaFkglsnLkvLdLsn 34 
                 +L++Ld+s N+  l+s++  +  +++nL++L+L++
  EFC37187.1 178 KLHTLDISGNNliLSSVKHLTKCQMPNLTELSLRQ 212
                 68999999999766777777777799999999975 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00025
                 TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 e+ k+ +nL++Ld++n ++t +s  +  ++++L++L ++ +
  EFC37187.1 275 EVLKNKPNLEYLDIGNYQITDIS-LSNGNCKNLTYLKITEC 314
                 66777788999999998999886.77777888888877665 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.075
                 TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8  25 snLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 s+ + L+L + +l  + p  ++++p L++L L+
  EFC37187.1 364 SSITNLKLDDSNLAPF-PSLIDHCPELKQLRLR 395
                 6777888888888888.8999999999999885 PP

  == domain 5  score: 0.3 bits;  conditional E-value: 0.17
                 TT--S-.EEE--S CS
       LRR_8  46 sgLpsLrsLdLsg 58 
                  +L++L++L ++g
  EFC37187.1 411 TCLSNLEYLSIDG 423
                 5677778887776 PP

  == domain 6  score: -0.2 bits;  conditional E-value: 0.24
                 T-SEEE-TTS--SEE-TTSSTT-TT--EE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvL 30 
                 nL++L  +n   ts+d +  ++++nL  L
  EFC37187.1 439 NLKELRFTNIEETSIDATILSNCTNLINL 467
                 56666666666667777777777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       769  (0.0428914); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 3062.68
//
Query:       EFC37188.1  [L=357]
Description: hypothetical protein NAEGRDRAFT_82008 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.005   16.9   0.3      0.008   16.3   0.3    1.4  1  SPRY      SPRY domain


Domain annotation for each model (and alignments):
>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.3   4.4e-07     0.008      52     108 ..     264     323 ..     190     332 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.4e-07
                 ETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTEEEEEEEESTTTS.....SEEEEEEE. CS
        SPRY  52 aeqskaygkqparegdviGvalDleegelsFtkngknlgvaFrnvrga.....elfPvvslg 108
                 ++ s+  gk     gd+  v++D+++++++F kng++   a +  +++     + fP++s+ 
  EFC37188.1 264 TVGSEFVGK--ISVGDRFAVIIDYDAKQVNFFKNGIHIASAITGTQDLvsqsvMYFPIISMC 323
                 444444444..6689**********************9888887777666678888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (357 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       393  (0.0219198); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.24s 00:00:00.64 Elapsed: 00:00:00.40
# Mc/sec: 2673.93
//
Query:       EFC37189.1  [L=177]
Description: hypothetical protein NAEGRDRAFT_82009 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.7e-06   25.7   4.2    8.9e-06   25.6   2.8    1.7  2  DUF2678        Protein of unknown function (DUF2678)
  ------ inclusion threshold ------
      0.018   13.9   8.0      0.022   13.6   8.0    1.0  1  AA_permease_2  Amino acid permease
       0.28   11.3   0.8       0.43   10.7   0.2    1.6  2  UPF0697        Uncharacterised protein family UPF0697
       0.43    9.9   6.2       0.53    9.6   6.2    1.1  1  TssN           Type VI secretion system, TssN


Domain annotation for each model (and alignments):
>> DUF2678  Protein of unknown function (DUF2678)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   2.8     2e-09   8.9e-06      16     114 ..       2     104 ..       1     108 [. 0.76
   2 ?   -1.4   0.0      0.48   2.2e+03       9      24 ..     115     130 ..     111     135 .. 0.83

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 2e-09
     DUF2678  16 nrplfgetsard.riinlvvggltsllvlvtvvssfvfpslppk.pl..niffavcillisssvivlifwyrqgdlepkfrnliyyilasivllclcan 110
                 ++pl+g+  ++  +i+  +  ++  l+ lvt +   vf   +    l  n+ ++v +++  +   +li+w r   lepk+r l+  + +  v+ c +a 
  EFC37189.1   2 ENPLYGDENSKAiKIATYTSSAIVILIGLVTFILLGVFTYRESDlKLwgNLAMMVYLIIQLVPLGILIYWQRTSYLEPKLRILMILTPILFVFGCAVAL 100
                 579999776665278888888899998899998877776554321332366667777777778889****************99999888999998888 PP

     DUF2678 111 lyfh 114
                 +y  
  EFC37189.1 101 FYVF 104
                 8865 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.48
     DUF2678   9 ygtsgldnrplfgets 24 
                 ygt+ ++ r+++g++s
  EFC37189.1 115 YGTTVVNGRTIVGKAS 130
                 8999999999999887 PP

>> AA_permease_2  Amino acid permease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   8.0   4.9e-06     0.022     319     403 ..      19     104 ..      12     126 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 4.9e-06
  AA_permease_2 319 gspiraiiltaivslillllfllassaaynfllsvsslgliisyllliigalilrkkrphlkr..pgkilvaiigalfllfllvalf 403
                     + ++++il+ +v++ill +f++  ++++ +  +++++ ++i+ l+++  ++++ +++  +++  + +il+ i++++++ ++l+  f
     EFC37189.1  19 YTSSAIVILIGLVTFILLGVFTY-RESDLKLWGNLAMMVYLIIQLVPLGILIYWQRTSYLEPKlrILMILTPILFVFGCAVALFYVF 104
                    5778999*******999988876.69**********************888888888777777444456666666666666665555 PP

>> UPF0697  Uncharacterised protein family UPF0697
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.2   5.5e+03      21      30 ..      26      35 ..      15      48 .. 0.53
   2 ?   10.7   0.2   9.7e-05      0.43      14      37 ..      51      74 ..      42      92 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.2
     UPF0697 21 llvilvslgl 30
                +l+ lv++ l
  EFC37189.1 26 ILIGLVTFIL 35
                2233333332 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 9.7e-05
     UPF0697 14 neatnvyllvilvslglllyarkn 37
                n a  vyl++ lv lg+l+y ++ 
  EFC37189.1 51 NLAMMVYLIIQLVPLGILIYWQRT 74
                67899***************9886 PP

>> TssN  Type VI secretion system, TssN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   6.2   0.00012      0.53      31     111 ..      20     104 ..       9     119 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00012
        TssN  31 kkliiyiLlaglvlalpgllgflknefvpygyillqilyll....lGilhlylllkkffkelkekkilfeilltlivillglvlf 111
                  +  i+iL+ ++++ l+g++ + + ++ ++g ++++++ ++    lGil  ++ + ++ ++l    il  il+++ +++  +++f
  EFC37189.1  20 TSSAIVILIGLVTFILLGVFTYRESDLKLWGNLAMMVYLIIqlvpLGILIYWQRTSYLEPKLRILMILTPILFVFGCAVALFYVF 104
                 45568899**************999999999888887776544458999999888888888888888888888888877777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       782  (0.0436165); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1050.00
//
Query:       EFC37190.1  [L=593]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.8e-45  154.4   0.0    4.2e-45  153.8   0.0    1.3  1  tRNA_synthFbeta  Phenylalanyl tRNA synthetase beta chain CLM 
    4.4e-26   91.6   0.1    7.5e-26   90.9   0.1    1.4  1  B3_4             B3/4 domain
    2.3e-24   85.4   0.8    8.8e-24   83.5   0.2    2.3  3  PhetRS_B1        Phe-tRNA synthetase beta subunit B1 domain
    2.1e-20   72.8   0.0    3.4e-17   62.5   0.0    2.6  2  B5               tRNA synthetase B5 domain


Domain annotation for each model (and alignments):
>> tRNA_synthFbeta  Phenylalanyl tRNA synthetase beta chain CLM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.8   0.0   9.5e-49   4.2e-45       1     214 []     375     589 ..     375     589 .. 0.94

  Alignments for each domain:
  == domain 1  score: 153.8 bits;  conditional E-value: 9.5e-49
  tRNA_synthFbeta   1 IpstlPkapttegelnkeqklrrklrdllagaGlnEvitysfvsekeldkll.eddderkavelanPlsedqsvlRtsLlpglLevlarNlarg 93 
                      Ip t+Pk +t+++ +n+ ++l++ +r +la++G++Ev++  +++++e+ k++ + +d ++a+ +a P   ++++ R sL+pglL++l++N +  
       EFC37190.1 375 IPITFPKSSTVGK-ENELNQLSEMVRLELAMSGYTEVLSLILCNDEENFKYMnRVNDGKTAIAVAEPCPFEFKTARISLIPGLLKTLQSNKSLP 467
                      99***********.99***********************************99999************************************** PP

  tRNA_synthFbeta  94 nedvrlFEigkvflkd.seeelpeeerhlaivltgkreeeswsekaravdfydlkgivealleslgi.ek...........vefepaehpalhp 174
                      ++ ++lFE+g+v+l d s++ +++++r+la++++  +            + + ++g+v++++e l +  +           +++ p+++ ++ p
       EFC37190.1 468 LP-IKLFECGDVILVDdSKDVGAKNNRRLAALFSSAT-----------SGLELIHGLVDRVMEVLAVpFEvehsqsvdkhcFSIFPSNDISFLP 549
                      **.**********************************...........*******************433455555555555555777****** PP

  tRNA_synthFbeta 175 grsAeikvdgkevGvlGelhpevleafdlkqrvyvfEldl 214
                      gr+A+i ++gk++G++G +hpev+ +f+lk++v+vfE++l
       EFC37190.1 550 GRQADIFYKGKKIGIFGIIHPEVASNFGLKTPVSVFEIEL 589
                      **************************************87 PP

>> B3_4  B3/4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.9   0.1   1.7e-29   7.5e-26       2     173 ..     110     274 ..     109     275 .. 0.93

  Alignments for each domain:
  == domain 1  score: 90.9 bits;  conditional E-value: 1.7e-29
                 SSEEEEEEEES--.-----HHHHHHHHHTT-----HHHHHHHHHHHHHT-.....-EEEEEGGGTBTEEE.EEE--TTEEEEBTTS-EEEE-T...... CS
        B3_4   2 cpryaarvlrgvkktapspewlqrrLrragirpinnvVDitNyvmlelgq.....PlhafDldkiqgdiv.vrlakegeklvtldgkerelde...... 88 
                 ++ ++++vlr++++t++                +n+++D+++++++++++     +++++Dld i+g+++  +l++++ k+++ld +e    +      
  EFC37190.1 110 RKFVVGAVLRNITFTEDA---------------YNSFIDLQEKLHQNICRkrtlvAIGTHDLDVIEGPFTyEALPPKEIKFIPLDRTELMD-Adelfaf 192
                 567899999999999999...............*************************************555566666******774444.457**** PP

                 ......................TSEEEETEEEEE.EETTTEEBTTTB--TT--EEEEEEEE--HHHHHHHHHHTT---HHHHHHHH---TTTHHHHHHH CS
        B3_4  89 ......................edlviadsekpv.slagvmggeeskvsedTknvfleaaafdpvsirktarrlglrseaskrfergvdpekleaaldr 164
                                       +++vi d+++ v sl+++++g++sk++ +Tknvf+e++a                          +d +k++++l++
  EFC37190.1 193 iekkgsemkhlspytkiikdspVYPVILDAKRRVlSLPPIINGDHSKIKMSTKNVFIECTA--------------------------TDLTKAKVVLNT 265
                 ********************************999**************************..........................************ PP

                 HHHHHHHHH CS
        B3_4 165 avallselc 173
                 +v+++se+c
  EFC37190.1 266 VVTMFSEHC 274
                 ********9 PP

>> PhetRS_B1  Phe-tRNA synthetase beta subunit B1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.5   0.2     2e-27   8.8e-24      19      83 .]       9      81 ..       4      81 .. 0.91
   2 ?   -2.9   0.0       1.9   8.5e+03      58      61 ..     304     307 ..     272     331 .. 0.51
   3 ?   -1.8   0.0      0.84   3.8e+03      19      31 ..     321     333 ..     305     368 .. 0.52

  Alignments for each domain:
  == domain 1  score: 83.5 bits;  conditional E-value: 2e-27
   PhetRS_B1 19 lteeeledllfefGlElDeiveeee........kkkadkkseeviykidipAnryDLLcleglaralkvFlgk 83
                + +  +e+l+f+fG+ElD++++e+          k ++k s+eviyki+ipAnryDLLc egl+ral++Flg+
  EFC37190.1  9 IADADFEQLCFDFGIELDDVTSERLmkekelgsAKDTSKLSDEVIYKIEIPANRYDLLCEEGLSRALNIFLGR 81
                57889******************988888787656799********************************985 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.9
   PhetRS_B1  58 idip 61 
                 ++  
  EFC37190.1 304 VEFT 307
                 3333 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.84
   PhetRS_B1  19 lteeeledllfef 31 
                 l+ ++++++l + 
  EFC37190.1 321 LSAQQIAEILTKM 333
                 4444444444332 PP

>> B5  tRNA synthetase B5 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.0    0.0011       4.9      13      55 ..      22      69 ..      10      72 .. 0.74
   2 !   62.5   0.0   7.5e-21   3.4e-17       4      67 .]     309     372 ..     306     372 .. 0.97

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0011
                TS---HHHHHHHHHHTT-E......EESSTTCEEEE--TT-TT--SHH CS
                xxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxx RF
          B5 13 GidlseeeiikiLkrlgce.....riekdkdlllVtvPswRsDleree 55
                Gi+l++ + ++++k+ ++       +++d+  +++++P+ R+Dl+ ee
  EFC37190.1 22 GIELDDVTSERLMKEKELGsakdtSKLSDEVIYKIEIPANRYDLLCEE 69
                5555555555555555554555556688999*************9987 PP

  == domain 2  score: 62.5 bits;  conditional E-value: 7.5e-21
                 EHHHHHHHHTS---HHHHHHHHHHTT-E.EESSTTCEEEE--TT-TT--SHHHHHHHHHHHH-G CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
          B5   4 rvekinkllGidlseeeiikiLkrlgceriekdkdlllVtvPswRsDlereeDliEEvaRlyGY 67 
                 + ++in+ +G++ls+++i++iL++++++++ +++++l+V  P++RsD+++++D++E+va+++GY
  EFC37190.1 309 NSDYINSRIGLNLSAQQIAEILTKMQLNATVTQNNELRVLAPPTRSDVLHACDIMEDVAIAHGY 372
                 679************************************************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (593 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       490  (0.02733); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 3681.02
//
Query:       EFC37191.1  [L=248]
Description: hypothetical protein NAEGRDRAFT_82011 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.96    9.2   5.6        1.9    8.2   5.6    1.4  1  M_domain        M domain of GW182


Domain annotation for each model (and alignments):
>> M_domain  M domain of GW182
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   5.6   0.00011       1.9      20      90 ..      47     121 ..      32     131 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00011
    M_domain  20 sfpqnnlm.ssalagsalgggggnanlaaLnsqkylsqg.sghggal.qggpqgvg.gssgaavarglqqqnaas 90 
                 sf+++n+  s + ags  g  ggn n  a n q+yl+q  s ++ +    g +  g ++ g++ + ++qq  +++
  EFC37191.1  47 SFNNANNYgSYGGAGSNYGTSGGNYNKYAQNTQSYLNQVdSVNSNPYsSYGSSYTGpSNYGSNYGSSFQQYLPPP 121
                 67777666677778888*********************7555555654555554444555777777777765554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (248 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       505  (0.0281667); expected 358.6 (0.02)
Passed bias filter:                      262  (0.0146132); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.21s 00:00:00.62 Elapsed: 00:00:00.38
# Mc/sec: 1979.71
//
Query:       EFC37192.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-19   68.1   1.0    8.6e-19   67.4   1.0    1.4  1  ADH_N          Alcohol dehydrogenase GroES-like domain
    6.2e-18   65.0   0.0    1.3e-17   64.0   0.0    1.5  1  ADH_zinc_N     Zinc-binding dehydrogenase
      1e-06   29.8   0.0    1.8e-06   29.0   0.0    1.4  1  ADH_zinc_N_2   Zinc-binding dehydrogenase
    0.00027   20.3   0.0    0.00047   19.5   0.0    1.3  1  AlaDh_PNT_C    Alanine dehydrogenase/PNT, C-terminal domain
     0.0008   18.8   0.0     0.0013   18.1   0.0    1.3  1  2-Hacid_dh_C   D-isomer specific 2-hydroxyacid dehydrogenase,
  ------ inclusion threshold ------
      0.015   14.8   0.2       0.69    9.4   0.0    2.1  2  Latexin        Latexin
       0.15   12.2   0.1       0.56   10.4   0.0    2.0  2  NAD_binding_2  NAD binding domain of 6-phosphogluconate dehyd


Domain annotation for each model (and alignments):
>> ADH_N  Alcohol dehydrogenase GroES-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.4   1.0   3.4e-22   8.6e-19       3     108 ..      42     145 ..      40     146 .. 0.93

  Alignments for each domain:
  == domain 1  score: 67.4 bits;  conditional E-value: 3.4e-22
                 EEEEEEEEEEE-HHHHHHHTTSTTTTSSSSEE---EEEEEEEEESTT-CS...--TT-EEEE-SEEE.-SSSHHHHTT-GGG-TTBEETTTS.S-SSSB CS
       ADH_N   3 evlikvkaagiCgsDlhilkggkelevklplilGHEivGeveevgpevkk...lkvGdrVvveplis.cgeCaaCkegeenlCeeakllgvs.ldGgfa 96 
                 ev ++v a++iC +D+h l++        ++i+GHEivG+v +vg++v+k   +kv drV + ++++ c eC++Ck++ enlC++   ++   + Ggf+
  EFC37192.1  42 EVFVEVIASSICYTDIHSLHN-------VGCIPGHEIVGIVRHVGEQVEKetkIKVSDRVGMGWHYTsCFECPTCKNHFENLCDKTLPFDKApIGGGFQ 133
                 89*****************97.......9*******************99999*********999888***************8887777666****** PP

                 SEEEECGGGEEE CS
       ADH_N  97 eyvvvpekklvk 108
                 + vv +++++++
  EFC37192.1 134 TGVVWDARFVFP 145
                 ******999987 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.0   0.0   4.9e-21   1.3e-17       1     129 [.     192     315 ..     192     316 .. 0.91

  Alignments for each domain:
  == domain 1  score: 64.0 bits;  conditional E-value: 4.9e-21
                 HHHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTTESEEEETTTCHHHHHHHHHTTTSSEEEEEESSCSHHHHHHHHHCEEEEEEEEECSC.TSSEEEEE CS
  ADH_zinc_N   1 gvGlaavqlAkalGaeviavdsseeklelakklGadevinykeadlverikeltggegvdvvfecvGsgatleaalkllkpgGrlvvvGg.gkgeeefd 98 
                 g+G++a+q+Ak +G++v+a + +++k + ++++Gade++ ++e   + + k+l    ++d ++++v +    +  +++lkp G++v+ G+  +g  + +
  EFC37192.1 192 GLGHLALQFAKKMGFHVVALSTNANKEKECRSFGADEFFVHTE---ENDAKSLS--CKFDMILNTVSTDIDNDKFIQMLKPFGKMVMLGLpDSGIYKAS 285
                 89************************************99955...56666666..49********************************65555559* PP

                 HHHHHHTT-EEEEE-SSCHHHHHHHHHHHHH CS
  ADH_zinc_N  99 lrnlllkeksilGsllgslreefkealdlla 129
                 +++l+lk++ i+Gs  ++ ++ +ke+l+++a
  EFC37192.1 286 AFPLILKDRAIVGSASAT-PDLMKEMLQFAA 315
                 ******************.9********976 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.0   0.0     7e-10   1.8e-06       2     128 ..     225     344 ..     224     349 .. 0.79

  Alignments for each domain:
  == domain 1  score: 29.0 bits;  conditional E-value: 7e-10
                   T-SEEEETTSTTHHHHH-TT-EEEEEES-HHHHH.HHHHHHEEEEEEEEE----.S-EEE-CHHHCTTT-EEEE--GGG...-.-HHHHHHHHHHHH CS
  ADH_zinc_N_2   2 GAdevidyrtedfeaatggegvDvvldtvggealleaslkvlpggGrlvsiggpplsaallkpakkrkgrsvkyeflfsmkasaqadileelaalie 98 
                   GAde++ +++e+ ++++ + ++D +l+tv ++   ++ +++l++ G++v++g p   +++ k +++    + ++     ++a    d+++e++++ +
    EFC37192.1 225 GADEFFVHTEENDAKSL-SCKFDMILNTVSTDIDNDKFIQMLKPFGKMVMLGLP--DSGIYKASAFPLILKDRAIVGS-ASA--TPDLMKEMLQFAA 315
                   9*****99955555677.556*********999989999999999******964..5566666665544444444444.334..5677********* PP

                   HHH----EEEEEEGGGHHHHHHHHHSS--S CS
  ADH_zinc_N_2  99 eGklrpvvdrvfpleeaaeAhrylesgrar 128
                   +++++p ++   +l+++ +A++++ +++ar
    EFC37192.1 316 DHNIKPQIE-LTTLDNVTQAVEKVLKNQAR 344
                   ********8.89************999987 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   1.8e-07   0.00047      31      99 ..     185     252 ..     179     257 .. 0.78

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.8e-07
                  EEEESTSHHHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTTTCECEEHCHHHHHHHHHHHH-SEEEE-- CS
  AlaDh_PNT_C  31 vlviGgGvaGlqAiatakglgakVtvlDvrparleqleslgakfvevlksqeellaeavkeadvvigtv 99 
                  v v+G G  G  A++ ak++g +V++l +++++ ++ +s+ga  + v + +e+  ++   + d++  tv
   EFC37192.1 185 VAVLGLGGLGHLALQFAKKMGFHVVALSTNANKEKECRSFGADEFFV-HTEENDAKSLSCKFDMILNTV 252
                  89*************************************99994333.223333333344566666665 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   5.1e-07    0.0013      36      81 ..     182     227 ..     171     273 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 5.1e-07
                   TSEEEEES-SHHHHHHHHHHHHTT-EEEEESSSHHHHHCHHHHTCE CS
  2-Hacid_dh_C  36 gktvGiiGlGrIGqavakrlkafgmkviaydrskkkeeeeeelgve 81 
                   +  v+++GlG +G+ + + +k++g++v+a +++ +ke+e+++ g++
    EFC37192.1 182 EFVVAVLGLGGLGHLALQFAKKMGFHVVALSTNANKEKECRSFGAD 227
                   55799****************************9999877766653 PP

>> Latexin  Latexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   0.00027      0.69      50     142 ..     206     299 ..     197     317 .. 0.81
   2 ?    3.5   0.1     0.017        44      28      60 ..     324     355 ..     308     360 .] 0.82

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00027
                 EEEEEEEEETTT---EEEEEEEEEE--TT-----EEEEEESS------HHHHHHHHHHHHH-SS--EEEEES-TTS---GGGHHH..HHHHHHHH CS
     Latexin  50 ydlefsveeyiseeelgkCsAevlfkkqkprpaievkctvegelkkrqqeedeefykklkklkkpleaqsiPdshGnidpelepi..wdLaivas 142
                 ++++    ++++e+e ++  A  +f +++++ a +  c++++ l++ +++ d+  + ++ k   ++ +  +Pds G  ++++ p+   d aiv+s
  EFC37192.1 206 FHVVALSTNANKEKECRSFGADEFFVHTEENDAKSLSCKFDMILNTVSTDIDNDKFIQMLKPFGKMVMLGLPDS-GIYKASAFPLilKDRAIVGS 299
                 55655556678888999999**********************************999999999999999****8.55555555541246677766 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.017
                 B-EEEEEEEEEEEEEETTTEEEEEEEEEEEETT CS
     Latexin  28 rlfvlatVqkaraedipkegakydlefsveeyi 60 
                 +l++l++V +a  e++ k++a+y +++ v+++ 
  EFC37192.1 324 ELTTLDNVTQAV-EKVLKNQARYRVVMAVNQAL 355
                 6889*******5.55*************99876 PP

>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   0.00022      0.56       2      78 ..     185     267 ..     184     320 .. 0.79
   2 ?   -0.9   0.0      0.65   1.7e+03      15      44 ..     315     344 ..     306     356 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00022
                    EEEE--SHHHHHHHHHHHHTT-EEEEE-SSHHHHHHHHHTT...EEE-SSHHHHHHHC....SEEEE-SSSHHHHHHHHHSHCC CS
  NAD_binding_2   2 igfiGlGvMGsnmalnllkagykvavynrtkekveelvaeg...akaaesieelvasl....dvvitmvkagkavdevieglle 78 
                    ++++GlG +G+   +  +k g++v++   +++k +e  + g   +  +++ e+ ++sl    d+++  v+ + + d++i+ l++
     EFC37192.1 185 VAVLGLGGLGHLALQFAKKMGFHVVALSTNANKEKECRSFGadeF-FVHTEENDAKSLsckfDMILNTVSTDIDNDKFIQMLKP 267
                    799*******8777778999*******999988888888775542.34444444555555679999999999888888888655 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.65
                    HHHHHHTT-EEEEE-SSHHHHHHHHHTTEE CS
  NAD_binding_2  15 alnllkagykvavynrtkekveelvaegak 44 
                    a + +k +++++  +  +++ve++++++a+
     EFC37192.1 315 ADHNIKPQIELTTLDNVTQAVEKVLKNQAR 344
                    556677788888888888888888888754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 2471.60
//
Query:       EFC37193.1  [L=274]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.1e-17   62.9   0.1    5.2e-17   62.2   0.1    1.4  1  F420_oxidored   NADP oxidoreductase coenzyme F420-dependent
    1.7e-08   34.8   0.2    1.1e-07   32.1   0.0    2.2  3  NAD_binding_2   NAD binding domain of 6-phosphogluconate dehy
    4.4e-07   29.4   0.0      7e-07   28.8   0.0    1.3  1  2-Hacid_dh_C    D-isomer specific 2-hydroxyacid dehydrogenase
    1.7e-06   27.9   0.1    2.8e-06   27.2   0.1    1.3  1  Rossmann-like   Rossmann-like domain
      7e-05   22.4   0.0    0.00011   21.9   0.0    1.3  1  IlvN            Acetohydroxy acid isomeroreductase, NADPH-bin
    0.00099   19.1   0.6      0.066   13.2   0.6    2.3  1  NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogen
      0.007   16.3   0.1      0.014   15.3   0.1    1.5  1  3HCDH_N         3-hydroxyacyl-CoA dehydrogenase, NAD binding 
  ------ inclusion threshold ------
      0.015   14.9   0.5       0.12   12.1   0.5    2.2  1  ApbA            Ketopantoate reductase PanE/ApbA
      0.028   13.7   0.0      0.047   13.0   0.0    1.4  1  AlaDh_PNT_C     Alanine dehydrogenase/PNT, C-terminal domain
       0.05   14.2   0.1       0.12   13.0   0.1    1.7  1  Pyr_redox       Pyridine nucleotide-disulphide oxidoreductase
      0.051   14.4   0.0      0.093   13.6   0.0    1.4  1  GFO_IDH_MocA    Oxidoreductase family, NAD-binding Rossmann f
      0.093   12.8   0.2       0.42   10.7   0.0    1.9  2  Shikimate_DH    Shikimate / quinate 5-dehydrogenase
       0.15   11.6   0.5       0.56    9.8   0.1    1.9  2  UDPG_MGDP_dh_N  UDP-glucose/GDP-mannose dehydrogenase family,


Domain annotation for each model (and alignments):
>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.2   0.1   3.8e-20   5.2e-17       1      97 []       2      93 ..       2      93 .. 0.96

  Alignments for each domain:
  == domain 1  score: 62.2 bits;  conditional E-value: 3.8e-20
                   EEEEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHHHHHC-EEECECHHHHHHH-SEEEE-S-HHHHHHHHHHCGHHHHTTSEEEEESSS CS
  F420_oxidored  1 kigiiGaGnmgealasgllaagaqpheivvansrnpekaeelaeelgvkvtavdneeaaeeadvvvlavkpedveevlselakdalkgklvisvlag 97
                   +igiiGaG++g+ la+ +++ g   h++++ nsr pe++++ ++e g  +ta + +e++++a  ++l+++++ v ++ ++l+++al++ ++++++++
     EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLG---HSVRISNSRGPETLKQVESETG--ATALPVAEVVKNAQLIILTIPTKGVFQLDRQLFESALENVVIVDTCNY 93
                   59********************...********************99..55566****************************************995 PP

>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.0   8.2e-11   1.1e-07       1      96 [.       2      97 ..       2     108 .. 0.91
   2 ?   -2.4   0.0       3.5   4.8e+03     112     122 ..     148     158 ..     139     178 .. 0.51
   3 ?   -0.6   0.0      0.93   1.3e+03      10      37 ..     188     216 ..     187     258 .. 0.64

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 8.2e-11
                   EEEEE--SHHHHHHHHHHHHTT-EEEEE-.SSHHHHHHHHHTTEEE-SSHHHHHHHCSEEEE-SSSHHHHHHHHHSHCCC--TT-EEEE-S---HHH CS
  NAD_binding_2  1 kigfiGlGvMGsnmalnllkagykvavyn.rtkekveelvaegakaaesieelvasldvvitmvkagkavdeviegllealkkgdilidgstssped 96
                   +ig+iG G +G+ +a+ +++ g++v + n r +e ++++ +e   +a  ++e+v++++++i+ ++  k v ++ ++l+e++ ++ +++d+ + +p+ 
     EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLGHSVRISNsRGPETLKQVESETGATALPVAEVVKNAQLIILTIPT-KGVFQLDRQLFESALENVVIVDTCNYNPSR 97
                   69***************************6778888888888888888999**************8.789999999****************99875 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3.5
                    EEEEEESHHHH CS
  NAD_binding_2 112 ldaPVSGGeeg 122
                    + +PVSG   +
     EFC37193.1 148 VAIPVSGDSLK 158
                    33444443332 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.93
                    HHHHHHHH.HHHTT-EEEEE-SSHHHHHH CS
  NAD_binding_2  10 MGsnmaln.llkagykvavynrtkekvee 37 
                    MG +m  n l +++ ++av   +++ +ee
     EFC37193.1 188 MGGPMYCNdLNREELEIAVQIANRSVMEE 216
                    88888766245566666655555445444 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0     5e-10     7e-07      38     124 ..       2      88 ..       1      93 [. 0.81

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 5e-10
                   EEEEES-SHHHHHHHHHHHHTT-EEEEESSSHHHHH..CHHHHTCEECSHHHHHHH-SEEEE-S--STTTTTSBSHHHHHCSTTTEEEE CS
  2-Hacid_dh_C  38 tvGiiGlGrIGqavakrlkafgmkviaydrskkkee..eeeelgvelvsleellaesDivslhlpltpetrhlinaeelakmkkgaili 124
                   ++GiiG+GrIG  +ak ++++g  v + + +  ++    e+e+g++   + e++++++ ++l++p +      ++++ +++  ++++++
    EFC37193.1   2 QIGIIGAGRIGAFLAKSFTQLGHSVRISNSRGPETLkqVESETGATALPVAEVVKNAQLIILTIPTKG--VFQLDRQLFESALENVVIV 88 
                   79*************************999988665666788899999*****************432..2334566666666666666 PP

>> Rossmann-like  Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   0.1   2.1e-09   2.8e-06      12      87 ..       2      76 ..       1      91 [. 0.79

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 2.1e-09
  Rossmann-like 12 svGiisaGrvGtalgaaleraghvvvgisaisaasreraerrlPdvpvlevedvaaraellllavPdaelpglvkg 87
                   ++Gii+aGr+G+ l++++ + gh v   ++    + ++ e    + + l+v +v+++a+l++l++P   + +l ++
     EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLGHSVRISNSRGPETLKQVESE-TGATALPVAEVVKNAQLIILTIPTKGVFQLDRQ 76
                   79**********************986655555554555544.567789*****************8877666555 PP

>> IlvN  Acetohydroxy acid isomeroreductase, NADPH-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.0   7.8e-08   0.00011       6      75 ..       2      72 ..       1      91 [. 0.84

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 7.8e-08
                -EEEES-SHHHHHHHHHHHHTT--EEEEE-TT-HHHHHHH.HTT-EEEEHHHHHHT-SEEEE-S-HHHHHH CS
        IlvN  6 kiaviGyGsqGhaqalnlrdsgldvvvglregsksvkkAk.eegfevltvaeavkkadvvmiliPDelqke 75
                +i +iG G  G   a+ + + g  v +++ +g +++k+ + e+g + l vae+vk+a+++++ iP +   +
  EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLGHSVRISNSRGPETLKQVEsETGATALPVAEVVKNAQLIILTIPTKGVFQ 72
                799******************************998887626799********************875444 PP

>> NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.6   4.8e-05     0.066       1      79 [.       2      67 ..       2      92 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.8e-05
                    -EEEE--SHHHHHHHHHHHTTT--EEEE-S-H.HHHHHHHHHSSBTTTBTT----TTEEEES-HHHHHTT--EEEE---H CS
  NAD_Gly3P_dh_N  1 kiavlGaGswGtalAkvlaenghevrlwvree.elieeineehenvkyLpgiklpenlvattdlaealkgadiivlvvPs 79
                    +i+++GaG  G  lAk++++ gh+vr+   +  e+++++++e    + Lp             +ae++k+a++i+l +P+
      EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLGHSVRISNSRGpETLKQVESETG-ATALP-------------VAEVVKNAQLIILTIPT 67
                    599***********************976554366666655433.33344.............34555555555555555 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.1     1e-05     0.014       1      39 [.       2      41 ..       2      65 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1e-05
                EEEEE--SCCHHHHHHHHHHTT-EEEEE-S.-HHHHHHHH CS
     3HCDH_N  1 kvaviGaGtmGagiaavfasagleVvlvdi.seealekal 39
                ++++iGaG +Ga +a+ f + g++V++ +   +e+l++++
  EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLGHSVRISNSrGPETLKQVE 41
                699***********************98763345555544 PP

>> ApbA  Ketopantoate reductase PanE/ApbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.5   8.5e-05      0.12       1     118 [.       3     122 ..       3     150 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 8.5e-05
                 EEEES-SHHHHHHHHHHHHHTHCEEEE-SCHHHHHHHHHCEEEEETTCEEEEEECEEECCHSCCCCS-ESEEEE-SSGGGHHHHHHHHGGGECTCE... CS
        ApbA   1 iailGaGaiGsllaakLakagadvtlilrsrrlealkknGlrltseggeeilrppealsaeekselepidlvivtvKayqteealeeikplldpnt... 96 
                 i i+GaG iG +la + ++ g+ v + + +       ++  +++se+g + l++ e++ ++         l+i+t+++  + +  +++ +   +n    
  EFC37193.1   3 IGIIGAGRIGAFLAKSFTQLGHSVRISNSRG-P----ETLKQVESETGATALPVAEVVKNA--------QLIILTIPTKGVFQLDRQLFESALENVviv 88 
                 79**********************9988877.3....333445555666666666665555........677777776666655555333333333344 PP

                 ...........EEEEESSS.SCHHHHHTTTSTTS CS
        ApbA  97 ...........vvlllqNG.lgheeelrealpkp 118
                            ++  +qNG l+h e + +++++p
  EFC37193.1  89 dtcnynpsrdgPIEEIQNGkLNHTEWISHYFNRP 122
                 4556666666666666666666666666666555 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   3.4e-05     0.047      31      99 ..       3      65 ..       1      97 [. 0.77

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.4e-05
                 EEEESTSHHHHHHHHHHHHTT-EEEEEESS.HHHHHHHHH.TTTCECEEHCHHHHHHHHHHHH-SEEEE-- CS
  AlaDh_PNT_C 31 vlviGgGvaGlqAiatakglgakVtvlDvr.parleqles.lgakfvevlksqeellaeavkeadvvigtv 99
                 + +iG+G  G   ++  ++lg +V++ + r p++l+q+es  ga+        +  +ae vk+a+++i t+
   EFC37193.1  3 IGIIGAGRIGAFLAKSFTQLGHSVRISNSRgPETLKQVESeTGAT--------ALPVAEVVKNAQLIILTI 65
                 669************************988689*******77766........444555555555555554 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   8.4e-05      0.12       2      28 ..       3      29 ..       2      56 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 8.4e-05
                EEEECSSHHHHHHHHHHHHTTSEEEEE CS
   Pyr_redox  2 vvvvGgGyiglElAgalaelgkkVtvv 28
                + ++G+G ig  lA+ +++lg++V + 
  EFC37193.1  3 IGIIGAGRIGAFLAKSFTQLGHSVRIS 29
                679*********************875 PP

>> GFO_IDH_MocA  Oxidoreductase family, NAD-binding Rossmann fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   6.8e-05     0.093       2      85 ..       2      84 ..       1      89 [. 0.77

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 6.8e-05
                  EEEEETTSHHHHHHHHHHHHTTTTEEEEEEECSSHHHHHHHHHHTTHEEESSHHHHHTCTTESEEEE-S-G....GGHHHHHHHHHHT CS
  GFO_IDH_MocA  2 rvaiiGaGkigskhlrplnesqrleevvalldpdaeraeavaesfgveaysdleelladpeidavivatpn....gtheelakaalea 85
                  +++iiGaG+ig   ++++ +  +  ++    ++++e  ++v  ++g+ a   ++e+++  +++++i ++p+    ++ ++l + ale+
    EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLGHSVRIS--NSRGPETLKQVESETGATALP-VAEVVK--NAQLIILTIPTkgvfQLDRQLFESALEN 84
                  79*************9999996665555..788999999999999988776.555555..5889999999966666666666666665 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0    0.0003      0.42      14      86 ..       2      68 ..       1      93 [. 0.73
   2 ?   -0.4   0.0      0.78   1.1e+03      38      57 ..     205     226 ..     193     258 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0003
                  EEEEES-SHHHHHHHHHHHCCT-CEEEEEE.SSHHHHHHHHHHHT.ET-EEEEGCGHHHHHHT-SEEEE-SSSS CS
  Shikimate_DH 14 kvlliGaGemaelvakhLlakgvkkvvvaN.Rtlerakelaeelkgeeiealkleelkellaeadvvisatase 86
                  ++ +iGaG+++  +ak + + g   v + N R  e  k++ +e +++   al++ e   ++++a ++i  + ++
    EFC37193.1  2 QIGIIGAGRIGAFLAKSFTQLGHS-VRISNsRGPETLKQVESETGAT---ALPVAE---VVKNAQLIILTIPTK 68
                  688****************99998.8898879999999998888666...666555...456666666665555 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.78
                   EEEEEESSHHHHH..HHHHHHT CS
  Shikimate_DH  38 kvvvaNRtlerak..elaeelk 57 
                   +v +aNR++   +  e+ ++l 
    EFC37193.1 205 AVQIANRSVMEEQylEIFKQLY 226
                   4789999876554113444443 PP

>> UDPG_MGDP_dh_N  UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   0.00041      0.56       1      26 [.       1      26 [.       1      31 [. 0.95
   2 ?   -0.8   0.0       0.7   9.6e+02      65      86 ..      46      67 ..      28      88 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00041
                    SEEEEE--STTHHHHHHHHHHCTSEE CS
  UDPG_MGDP_dh_N  1 mkisviGlGYvGlvtaavlaeighev 26
                    m+i +iG+G +G+  a  + ++gh v
      EFC37193.1  1 MQIGIIGAGRIGAFLAKSFTQLGHSV 26
                    89**********************98 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.7
                    EEES-HHHHHHC-SEEEE---- CS
  UDPG_MGDP_dh_N 65 sfttdvekaveeadvifiaVgT 86
                       + v + v++a++i+++++T
      EFC37193.1 46 ATALPVAEVVKNAQLIILTIPT 67
                    4455677778888888888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       516  (0.0287802); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1709.56
//
Query:       EFC37194.1  [L=329]
Description: hypothetical protein NAEGRDRAFT_60995 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-54  185.7   0.0    5.6e-30  104.3   0.0    2.1  2  Actin     Actin
     0.0023   16.8   0.1      0.034   13.0   0.0    2.3  2  MreB_Mbl  MreB/Mbl protein
  ------ inclusion threshold ------
       0.12   11.3   0.0       0.18   10.8   0.0    1.2  1  PilM_2    Type IV pilus assembly protein PilM;


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.3   0.0   9.4e-34   5.6e-30       3     192 ..       4     188 ..       2     215 .. 0.86
   2 !   79.5   0.0     3e-26   1.8e-22     271     390 ..     218     328 ..     214     329 .] 0.89

  Alignments for each domain:
  == domain 1  score: 104.3 bits;  conditional E-value: 9.4e-34
       Actin   3 evsavVlDnGssttraGyagedaPkavipslv.gkprgrkveaklyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelk.vdpeehplll 99 
                 +++ vV+D Gs+t+  Gy+ +d P+++i   + g++r        ++ +++l       +++p+++G+++  d+ e ++eh + ee+k ++ +e+p+l+
  EFC37194.1   4 HNTKVVIDLGSGTISTGYGMDDEPTSDINKSLtGQSRRI----YSKIKSNSLL----PDLKYPIDKGIITQLDDLELMLEHLILEEMKiIEMKEYPILI 94 
                 6788*********************99976550554443....3455555444....6899*************************7625789****** PP

       Actin 100 t.epplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknv 192
                   ++ +n +  r  ++EivfEk++vp + la+ ++ls+ asg++tglv+ sG+  t  v++ +G+vL+++ + +++gG++L+  l++l+++   
  EFC37194.1  95 GyNSLNNVKRTRVGITEIVFEKLGVPVFALADRNMLSLLASGRTTGLVLKSGDCITNSVTIDEGQVLTQHCCGVEFGGRDLSLFLEKLIENCGY 188
                 72556778999*****************************************************************************998544 PP

  == domain 2  score: 79.5 bits;  conditional E-value: 3e-26
       Actin 271 klgeeRfkvpEiLFdpsligsesaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerky 369
                  ++++Rf + + +++  + g    l    +  ++i+eli ++++++d + ++e  +ni+++GGn+l+p++teRl++el+      +  +++ap+ erky
  EFC37194.1 218 HWETQRFDICDRYYEIGENGISLGL---DQYKSSIHELILKSLQHLDSKFKEECQKNIILSGGNTLFPNFTERLKRELNL-----TPCRVVAPP-ERKY 307
                 6788899999999887666665553...467789********************************************99.....45799****.**** PP

       Actin 370 saWiGGSiLAslgtfqqlwvs 390
                 s+WiGGSiL+s++ + ++w+ 
  EFC37194.1 308 SSWIGGSILSSIQGVDSMWIL 328
                 *******************96 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0      0.73   4.4e+03     146     156 ..       6      16 ..       3      18 .. 0.76
   2 !   13.0   0.0   5.7e-06     0.034      62     300 ..      58     295 ..      54     307 .. 0.69

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 0.73
                 -EEEEEE-SS- CS
    MreB_Mbl 146 gnmvvdiGggt 156
                  ++v+d+G+gt
  EFC37194.1   6 TKVVIDLGSGT 16 
                 67899999988 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 5.7e-06
                 SEETTEESSHHHHHHHHHHHHHHHHTSS-SS--EEEEEE-SS--HHHHH..HHHHHH.HHTT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-E CS
    MreB_Mbl  62 PlkdGviadlevaeellkyfikkvkkkkslskprvvicvPsgiteverr..Avkeaa.kkaGarevllieeplaAAiGaglpveepsgnmvvdiGggtt 157
                 P+ +G+i++l+  e +l+++i +  k   +++  ++i+  s +++v+r    ++e++ +k+G     l +  ++  + +g      +  +v+  G   t
  EFC37194.1  58 PIDKGIITQLDDLELMLEHLILEEMKIIEMKEYPILIGYNS-LNNVKRTrvGITEIVfEKLGVPVFALADRNMLSLLASG-----RTTGLVLKSGDCIT 150
                 88888888888888888888888888888888888888754.45555441156665426677777777777887777666.....45668888888888 PP

                 EEEEEETTEEEEEEE..ES-SHHHHHHHHHHHHHHHHSEE--HHHHHHHHHHH-BSS--HHHH.EEEEEEEET.TTTCEEEEEEEHHHHHHHHHHHHHH CS
    MreB_Mbl 158 evavislggivtsks..vrvaGdeldeaiikyirkkynlliGertaekikieigsavkeeeee.kmeikGrdl.vtglpkevevsseevrealkepvsa 252
                 + + i  g++ t++   v  +G +l   + k+i  +    iGe+   +  +e    +k++  + +m+ +          +  e+ ++ ++  l +  s+
  EFC37194.1 151 NSVTIDEGQVLTQHCcgVEFGGRDLSLFLEKLIE-NCGYKIGEEFDSSTGVEHLIQIKQRLCQiSMDYHWETQrFDICDRYYEIGENGISLGLDQYKSS 248
                 8888888888887652266788887765555553.3444455544333333322222222222334433333302334588999*************** PP

                 HHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS- CS
    MreB_Mbl 253 iveavkevLektppeLaadivdrgivltGGgallkgldkllseetglp 300
                 i e + + L++       + +++ i+l+GG +l+ ++ + l++e++l 
  EFC37194.1 249 IHELILKSLQHLDSKFKEE-CQKNIILSGGNTLFPNFTERLKRELNLT 295
                 **************99877.5788*******************99984 PP

>> PilM_2  Type IV pilus assembly protein PilM;
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   3.1e-05      0.18     219     307 ..     213     302 ..     202     308 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 3.1e-05
      PilM_2 219 ivrrYglsleeaekkkrsgslPedyeeevlepflealaqeisralqffltssqqnkvdkilLaGGtaslpgleelleeelgi.sttvanp 307
                 i+  Y  +++  +   r  +++e+  +  l  ++ ++ + i ++lq   +  +++  ++i+L+GG+  +p+++e l+ el++ ++ v+ p
  EFC37194.1 213 ISMDYHWETQRFDICDRYYEIGENGISLGLDQYKSSIHELILKSLQHLDSKFKEECQKNIILSGGNTLFPNFTERLKRELNLtPCRVVAP 302
                 556677777777777777888888888889999999***********999999999**********************998524666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       509  (0.0283898); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 2366.57
//
Query:       EFC37195.1  [L=574]
Description: hypothetical protein NAEGRDRAFT_82014 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.1e-06   25.3  13.5    6.5e-05   22.3   8.2    2.5  2  Far-17a_AIG1  FAR-17a/AIG1-like protein
  ------ inclusion threshold ------
      0.018   15.3   0.0        0.2   11.8   0.0    2.5  2  Shisa         Wnt and FGF inhibitory regulator
       0.16   12.3   0.2        2.2    8.6   0.0    2.4  2  Ly49          Ly49-like protein, N-terminal region
        0.2   11.6   0.4       0.61   10.1   0.1    1.9  2  DUF4446       Protein of unknown function (DUF4446)
        0.7    9.3   3.5        1.3    8.4   3.5    1.5  1  TMEM156       TMEM156 protein family
        1.9    8.7   7.1       0.84    9.9   2.2    2.8  3  HemY_N        HemY protein N-terminus


Domain annotation for each model (and alignments):
>> Far-17a_AIG1  FAR-17a/AIG1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   8.2   2.2e-08   6.5e-05      31     193 ..     144     335 ..     115     337 .. 0.82
   2 !    6.8   0.8    0.0012       3.7      80     136 ..     333     399 ..     330     415 .. 0.75

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 2.2e-08
  Far-17a_AIG1  31 ayGgkfkyLtfiglvlqalfftlallaD.............................eltlsallklrdnllavlafPvevlvsvlFWgLyliDrel 98 
                    +   f + t ++ ++ a+++ l+ +                                ++l   ++ + +lla ++   +v+v++ +W +++ D + 
    EFC37195.1 144 DFMTYFSFFTNTSALVLAIYYVLQSVFGlfyitscykyfnesetegptksldelhplVRKLFSFVSTVLWLLAEWNHVSAVVVVIGYWVMVIPDLAN 240
                   55566889999999999999988888888899999999999999999999999998888888888999999999999999***************** PP

  Far-17a_AIG1  99 vypklldelipdWlnhsmHtvvlvailleifllkhkypsrlaalalsaafallYliwiervaqfng..vwvYPvlealslegrvlffalsavvmall 193
                     p   d    +++  + H ++l++ ++e+fl++     r+  ++l+  +  +Y iw+ ++  +     w+Y +++  ++++  ++f++  ++++++
    EFC37195.1 241 GNPTNNDPDPMSYFTFGYHGMNLLFNIIEFFLSNL--VFRIWHIFLVLLYPSIYCIWVQVILETGAatKWPYGIIDYYRFPWYSVIFFVFGIFLVFV 335
                   *99998888888********************988..67999999999**********99988544559*************999998887777655 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0012
  Far-17a_AIG1  80 vevlvsvlFWgLyliDrelvypklldel...........ipdWlnhsmHtvvlvailleifllkhkyp 136
                   v v+v++++W + +i   ++  k l+++           +  ++  s+Ht+v  +i ++ ++ + ++ 
    EFC37195.1 333 VFVIVFIIYWVITTIRLMIL-TKKLKNIrvflrrrdtekVSGLVADSVHTFVNTVIEMDQIMEESHPS 399
                   6799********99966555.6667888999*****999999********666666666655555444 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.36   1.1e+03      84     116 ..      17      50 ..       7      90 .. 0.66
   2 ?   11.8   0.0   6.9e-05       0.2      82     175 ..     320     420 ..     301     436 .. 0.51

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.36
       Shisa  84 vpvlivktifivfvivgvvvivcccgc.lkkkqr 116
                 vp li++t++  f  ++  +++++++  ++  q+
  EFC37195.1  17 VPSLIISTNVTTFFFIIFGAVTVLITKgFRFQQK 50 
                 6788999998877666666666664430333333 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 6.9e-05
       Shisa  82 iyvpvlivktifivfvivgvvvivcc...cgclkkkqrekr.....pgrenlssalaev.gpivtettsattvvhsrysepqqssssssypgatnqgyq 171
                  y  +  v  if vfviv ++  v+      +l+kk ++ r        e++s  +a++ ++ v +  + +++++ ++  p+q+s+  +   +    ++
  EFC37195.1 320 WYSVIFFVFGIFLVFVIVFIIYWVITtirLMILTKKLKNIRvflrrRDTEKVSGLVADSvHTFVNTVIEMDQIMEESH--PSQPSVHYRANSTISTAVS 416
                 566777788888888887665443332237788887776664443333444444444443333332223333333333..4444433332222233333 PP

       Shisa 172 pvpv 175
                 + p+
  EFC37195.1 417 STPP 420
                 3332 PP

>> Ly49  Ly49-like protein, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.0   0.00075       2.2      11      50 ..      26      65 ..      17      96 .. 0.81
   2 ?    0.9   0.1      0.18   5.4e+02       3      34 ..     319     351 ..     317     412 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00075
                XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXX CS
        Ly49 11 lgILclllLvtvavLvtkifqysqekheleetlnlsqnys 50
                +  + +++  +v+vL+tk f+++q+k +++e ++ +q   
  EFC37195.1 26 VTTFFFIIFGAVTVLITKGFRFQQKKTRTDEYIKQRQMTF 65
                55566677779*********************98887654 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.18
                 XX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        Ly49   3 pw.klivvalgILclllLvtvavLvtkifqysq 34 
                 pw  +i  ++gI+ ++ +v ++  v++ ++ + 
  EFC37195.1 319 PWySVIFFVFGIFLVFVIVFIIYWVITTIRLMI 351
                 562356778999999988888888777776554 PP

>> DUF4446  Protein of unknown function (DUF4446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.2   3.4e+03       5      63 ..      33      91 ..      27      98 .. 0.57
   2 ?   10.1   0.1    0.0002      0.61       2      67 ..     330     395 ..     326     410 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.2
     DUF4446  5 vlavlvvillillivllvklkklkkkykklmkgkdgksleellkekleeveelkeesee 63
                ++++++v++   + ++  k++  +   ++ m+ + gk+ +++ k ++++ +el++e ++
  EFC37195.1 33 IFGAVTVLITKGFRFQQKKTRTDEYIKQRQMTFRLGKDPNSVPKPNFSDQKELEKEDKK 91
                44444444444444444444444434455566667777777777777777777777776 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.0002
     DUF4446   2 iilvlavlvvillillivllvklkklkkkykklmkgkdgksleellkekleeveelkeeseeleke 67 
                 i+lv++++++i ++++ + l+ l+k  k+++ +++++d +++  l+++ +++  +   e++++++e
  EFC37195.1 330 IFLVFVIVFIIYWVITTIRLMILTKKLKNIRVFLRRRDTEKVSGLVADSVHTFVNTVIEMDQIMEE 395
                 445555666666666666666666666677888888888888888888777776666666665554 PP

>> TMEM156  TMEM156 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   3.5   0.00044       1.3     175     226 .]     317     370 ..     293     370 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00044
     TMEM156 175 kitWyvlvllvf....ifliiliihKileehrrvqkwqshkykatsvllrgkdsek 226
                 +  Wy+++  vf    +f+i++ii+ ++   r   +   +k k   v+lr++d ek
  EFC37195.1 317 RFPWYSVIFFVFgiflVFVIVFIIYWVITTIR--LMILTKKLKNIRVFLRRRDTEK 370
                 677*****999876668889999999999999..77788999999999**999987 PP

>> HemY_N  HemY protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.75   2.3e+03      12      33 ..      22      41 ..      17      63 .. 0.57
   2 ?   -2.5   0.1         2     6e+03      25      43 ..     157     175 ..     146     187 .. 0.58
   3 ?    9.9   2.2   0.00028      0.84      15      56 ..     322     365 ..     320     379 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.75
      HemY_N 12 ietslvvavlllvllfvllyll 33
                i+t+++++++++++++ +l  +
  EFC37195.1 22 ISTNVTTFFFIIFGAVTVL--I 41
                4455554444444444433..3 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2
      HemY_N  25 llfvllylllrllrlllrl 43 
                 +l++++y +l+ + +l+ +
  EFC37195.1 157 ALVLAIYYVLQSVFGLFYI 175
                 4555555555555555544 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00028
      HemY_N  15 slvvavlllvllfvllylllrllrlllrl..parvrrwrrrrre 56 
                 s++++v+ ++l+fv++++++++++++  +   +++++ r   r+
  EFC37195.1 322 SVIFFVFGIFLVFVIVFIIYWVITTIRLMilTKKLKNIRVFLRR 365
                 899*******************9987655554444443333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (574 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1179  (0.0657594); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.46
# Mc/sec: 3786.73
//
Query:       EFC37196.1  [L=474]
Description: hypothetical protein NAEGRDRAFT_59832 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.026   15.2   0.2       0.11   13.1   0.1    2.0  2  EST1      Telomerase activating protein Est1
      0.037   13.9   0.8      0.063   13.2   0.8    1.3  1  Draxin    Draxin
        0.1   13.1   1.1        1.3    9.7   0.3    2.7  2  Pox_A21   Poxvirus A21 Protein


Domain annotation for each model (and alignments):
>> EST1  Telomerase activating protein Est1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   1.8e-05      0.11      62     131 ..      54     117 ..      29     121 .. 0.69
   2 ?   -0.7   0.0      0.33     2e+03      74      95 ..     254     275 ..     157     338 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.8e-05
                 HHHHH-B-.HTT............-.....---------TTB--TTSHHH.HHHHHHHHHHHHHHHHHHHH CS
        EST1  62 rllsefel.elssvlkvilksktklpekessekseteseeeksslssseqksavlklvhrcLiyLGDlaRY 131
                 +l+++f+  e  s+++ +  + +++ ++ ss       +++++++ss++     l  ++  L++LGD +RY
  EFC37196.1  54 SLIRIFDSkEYYSIVHNTRHQADNYLDNSSS-------SSQQLNNSSTNSTVDPLNGCYTILLNLGDFSRY 117
                 4555555333335555444455554444433.......4555555555555888999************** PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.33
                 ...........-.....----- CS
        EST1  74 vlkvilksktklpekessekse 95 
                 +++ i k+ ++ + + ++++++
  EFC37196.1 254 LAHKITKKGNGKSSNNTTTNTS 275
                 3333333222222222222222 PP

>> Draxin  Draxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.8     1e-05     0.063     113     210 ..     260     359 ..     242     374 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1e-05
      Draxin 113 rrdkvrkkkgkalepepssllkdreafedqlqkas...leeassplapvllalt.alvatviteepptlppastkpqqarvkkdGdvmPtldmaLFDWt 207
                 ++ + +  + ++  +++s+ +   eaf++++  +s   ++e+s +++pv ++   + va++ +e+++t p a  k+++a   +  dv   + m  FD t
  EFC37196.1 260 KKGNGKSSNNTT--TNTSTNTTIVEAFQNNADVQSngvMNESSGATSPVSNISIdSSVALTRNESSNTSPRAFLKKKSASNFSLKDVDRSVKMVDFDVT 356
                 333333222222..22233344444555444444355599999999999888777999*******************999999**************** PP

      Draxin 208 DYE 210
                 +Y 
  EFC37196.1 357 EYS 359
                 **5 PP

>> Pox_A21  Poxvirus A21 Protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0     0.095   5.7e+02       8      42 ..     205     236 ..     200     298 .. 0.62
   2 ?    9.7   0.3   0.00021       1.3       4      34 ..     398     435 ..     395     455 .. 0.66

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.095
     Pox_A21   8 lcyFilifniivpaileklrlekeafekykklkkk 42 
                 ++yF+l   +i+pai+   rl      ++ +l+k 
  EFC37196.1 205 VTYFVLPPSLILPAIFRCYRLVLL---HLLNLRKM 236
                 78************9866554433...33333344 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00021
     Pox_A21   4 LFlvlcyFili.fniivpail......eklrlekeafe 34 
                 LF+vlcyFi+  + +i+  i+      +klr+ +++f+
  EFC37196.1 398 LFIVLCYFIIFsLHVILFLIMggiewdQKLRKGTTIFT 435
                 9*******963234555544411113356666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1285  (0.0716716); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.38s 00:00:01.05 Elapsed: 00:00:00.54
# Mc/sec: 2656.07
//
Query:       EFC37197.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 1535.08
//
Query:       EFC37198.1  [L=821]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-53  177.7  26.5    4.6e-11   42.3   0.0   11.7 10  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.82    9.4   6.1        1.2    9.0   0.1    3.6  4  DUF2247   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.0   8.7e-11   7.8e-07       4      49 .]      92     137 ..      89     137 .. 0.97
   2 !   23.8   0.7     3e-09   2.7e-05       1      35 [.     114     148 ..     114     209 .. 0.91
   3 !   24.9   0.0   1.4e-09   1.3e-05       1      35 [.     208     242 ..     208     260 .. 0.90
   4 !   26.0   0.5   6.1e-10   5.5e-06       1      49 []     333     381 ..     333     381 .. 0.87
   5 !   10.9   0.1   3.1e-05      0.28       4      32 ..     386     414 ..     384     416 .. 0.92
   6 ?    1.5   0.0     0.027   2.4e+02      19      49 .]     427     457 ..     424     457 .. 0.91
   7 !   27.0   0.4     3e-10   2.7e-06       1      49 []     459     507 ..     459     507 .. 0.92
   8 !    7.2   0.0   0.00044         4      11      35 ..     494     518 ..     491     523 .. 0.86
   9 !   33.1   0.0   3.7e-12   3.3e-08       3      45 ..     712     754 ..     710     755 .. 0.95
  10 !   42.3   0.0   5.1e-15   4.6e-11       2      49 .]     736     783 ..     735     783 .. 0.98

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 8.7e-11
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++++++   g+ ++y+s  L++D+++++  vk +  +++ as+eLr
  EFC37198.1  92 FMKKLIMLRGWLIRYASQQLTSDRQFMMSVVKEHQVCFRSASKELR 137
                 9********************************************8 PP

  == domain 2  score: 23.8 bits;  conditional E-value: 3e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 Dr++++ +vk +  +++ +s+eL++D+e++ +A+ 
  EFC37198.1 114 DRQFMMSVVKEHQVCFRSASKELRSDRELLEAALD 148
                 9********************************75 PP

  == domain 3  score: 24.9 bits;  conditional E-value: 1.4e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 +rE+vl+avk +gs+l+y ++++k D eiv  A++
  EFC37198.1 208 NRELVLQAVKYYGSVLRYSNSKFKADPEIVGTALE 242
                 8****************************988877 PP

  == domain 4  score: 26.0 bits;  conditional E-value: 6.1e-10
     DUF4116   1 DrEivleavk.kngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Ei l++v+  +++alky+se+L+++ +++l ++k+    ++++s+e+r
  EFC37198.1 333 DEEI-LQIVTrLYPKALKYASERLRSNLDLILPILKREHELIEFVSKEIR 381
                 5566.445443889**********************************98 PP

  == domain 5  score: 10.9 bits;  conditional E-value: 3.1e-05
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlk 32 
                 +++e+++kngs+l+ + ++++++ e+++ 
  EFC37198.1 386 VAKELLSKNGSILNLFGDSIRKNAEFIKS 414
                 6799**********************986 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.027
     DUF4116  19 lseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +++eL+++  ++   v+++ t+++ a  eLr
  EFC37198.1 427 FPKELRSNHHLIELLVRRSYTFFKCATLELR 457
                 69********************999988876 PP

  == domain 7  score: 27.0 bits;  conditional E-value: 3e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D E+v++  ++++ +++++s++Lkn+ e++  A  +n  ++  +s +Lr
  EFC37198.1 459 DFEFVKQMYDIDWRIIEFASDNLKNNSEFMRFATSRNALSFANFSRSLR 507
                 88*********************************99988887777776 PP

  == domain 8  score: 7.2 bits;  conditional E-value: 0.00044
     DUF4116  11 kngsalkylseeLknDkeivlkAvk 35 
                 +n +++ ++s +L+ ++ei++++v+
  EFC37198.1 494 RNALSFANFSRSLRGNIEIIKECVN 518
                 666777789**************96 PP

  == domain 9  score: 33.1 bits;  conditional E-value: 3.7e-12
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                  ++l ++k+ gs lky+s++++   eiv+ Av +++t+l +as
  EFC37198.1 712 KFMLLILKNSGSLLKYASDRIRDTEEIVKLAVSSDSTSLAFAS 754
                 69***************************************99 PP

  == domain 10  score: 42.3 bits;  conditional E-value: 5.1e-15
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +Eiv+ av++++ +l ++s++L+nDk+iv  Av ++  ++ +aseeLr
  EFC37198.1 736 EEIVKLAVSSDSTSLAFASNRLRNDKDIVRMAVSSSALNFAFASEELR 783
                 7**********************************************8 PP

>> DUF2247  Uncharacterized protein conserved in bacteria (DUF2247)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1     0.091   8.2e+02      60     110 ..      17      73 ..       4      75 .. 0.69
   2 ?    0.3   0.2     0.059   5.3e+02      22      50 ..     250     277 ..     227     324 .. 0.73
   3 ?   -2.9   0.0      0.59   5.3e+03      21      37 ..     302     318 ..     286     347 .. 0.74
   4 ?    9.0   0.1   0.00013       1.2       3      63 ..     462     546 ..     461     564 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.091
     DUF2247  60 elknllkklaseekkid...eeleerkwlyvvL...kelkelskdfeepLeeveeiy 110
                  + +ll++l + +k+++    +++ +k++ + L   + l++++ ++ e L++ e+ y
  EFC37198.1  17 PVIILLDDLSEPCKNSNlysHNINFHKLRKFRLidqLALFKKKMEYIECLKKCEDNY 73 
                 566777777777555441115677777776666666889999999999999888766 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.059
     DUF2247  22 nlisadevieyaekllekgeaseelileL 50 
                 ++i+++   e a kl+++++ +++ + +L
  EFC37198.1 250 KWIKKEIYSELALKLVMNKD-NNKQFSQL 277
                 46666666666666666666.55555444 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 0.59
     DUF2247  21 knlisadevieyaekll 37 
                 k +++ +ev+ ya+  l
  EFC37198.1 302 KRFFTIKEVVRYAKDDL 318
                 56777888888887655 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00013
     DUF2247   3 fkkkgikldWkdiyvGle........................knlisadevieyaekllekgeaseelileLafleekeeeelkn 63 
                 f k++ ++dW++i+++                          + l +  e+i+ + ++  k+   ee + e++++  + ++e+k 
  EFC37198.1 462 FVKQMYDIDWRIIEFASDnlknnsefmrfatsrnalsfanfsRSLRGNIEIIKECVNMALKQGFREEKVYEMIICRSFGKDEFKT 546
                 7899999********9999999999999999999999999988888999*********999999*************99999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (821 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       744  (0.041497); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.49
# Mc/sec: 5066.97
//
Query:       EFC37199.1  [L=565]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-21   75.1  17.3    4.7e-21   75.1  17.3    1.8  2  MFS_1     Major Facilitator Superfamily
  ------ inclusion threshold ------
        5.6    5.0  10.4       0.53    8.3   1.9    2.3  2  UPF0182   Uncharacterised protein family (UPF0182)


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.1  17.3   5.2e-25   4.7e-21       2     352 ..      88     517 ..      85     518 .. 0.78
   2 ?   -1.5   1.2       0.1     9e+02     134     164 ..     525     552 ..     516     561 .. 0.68

  Alignments for each domain:
  == domain 1  score: 75.1 bits;  conditional E-value: 5.2e-25
       MFS_1   2 llaaflsalarsilgpalplalaedlg........ispseigl...lltl.yalgaavaslplGrlsdrfGrrrvlllglllfalglllllfa.....s 83 
                 ++++ +++++ ++++ +l+ + +e  +        +    +++   +++l + ++++  +++++++  rfG ++ + +  +l+++g+++ l++     +
  EFC37199.1  88 CMVTSIICMSTYTTSGNLW-CPNEIVHairtllmkFYRLDANWkinMTSLvFLIATIPITFLVSFVLKRFGLKWSVSIYSILTCIGAWIRLIGiqgneT 185
                 4555566666666666666.888888855555444334446666656666366677999999999999******9999999999998999963457889 PP

       MFS_1  84 slwlllvlrvlqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggllasslg...........Wravfyilaivsllafv.lfll 170
                 s+wl l++ ++ + g+ +++  g  + + wf  +er+ +  ++  +  +G++l +l+g+ l++ ++             ++f+ + +v++ ++v l+ll
  EFC37199.1 186 SFWLSLIGQIFIACGQPFITQCGDLFGVFWFGNKERTVVQVVVLFSGVFGSLLSYLVGPRLMTIGSeseedlkisdlGLGIFLGIQGVMATLCVfLVLL 284
                 999***********************************************************8988**********95555555555555544447779 PP

       MFS_1 171 llpeepperkrkspkeee...........................................kgtgpaplvp......awkallkdpvlwillialllff 220
                 ++  +pp+++  +p++ +                                           k+ +p+ + p      ++k+l + p     +++ll ++
  EFC37199.1 285 FFKSKPPTPPAIAPEPTKeesnpgfngdltqsltegsntaeeplsnqdletsaaetkqsktKQEEPKDVYPpqtfvfGLKKLIRLP----SFFMLLAAS 379
                 998888888888888888889************************99999999888887776666666666999999899999999....555555555 PP

       MFS_1 221 fgfsglltllplylqevlgls..glllaglllallalvgailallagrlsdrlgrrrrlllallllllaalglallavt..ssavllll.....vlvli 310
                 + ++++++ + ++  +  + +  +++ +g l  +l +++ i++++++ l d+++  + ++++ ++ +++a++++ + +   +    +ll     ++vli
  EFC37199.1 380 TLINSFFQSIYIL-EQIIKGNkyTAIDSGNLNIILIVFATISSIVLSILFDKTKQFKLITIITSASACLAFLWFCILMLwqK--NDVLLvlsgmSFVLI 475
                 5666666666664.4444444453688887777888888888**********998777777777777777777777777542..33333346769999* PP

       MFS_1 311 Gfglgfvfpsllalasdlappeeagtasglfntagslggalg 352
                 G+++  ++p+l+ +++  + p +  t + + +t+ +l ++l+
  EFC37199.1 476 GMFSVPTMPLLNQMIVYTTYPVHPSTTMTISSTLTTLWSILF 517
                 **99999************999999********999999987 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.1
       MFS_1 134 ailgpllggllasslgWravfyilaivslla 164
                  +++pl+ ++++   +   vf+i+a+v++++
  EFC37199.1 525 QLCTPLAPSIIL---WTDFVFLIIAFVLIVS 552
                 556666666666...6677777777777776 PP

>> UPF0182  Uncharacterised protein family (UPF0182)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   1.6    0.0095        86     144     213 ..      79     161 ..      73     199 .. 0.74
   2 ?    8.3   1.9   5.9e-05      0.53     187     274 ..     365     452 ..     351     464 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.0095
     UPF0182 144 lllslllalvllaliavllvyllsgesl...girl.........kfaelskaarrhls...vllallllllalsywLdryellys 213
                 + + +++al++++ i+++ +y  sg++    +  +         kf +l+++ +++++   +l+a++ ++  +s++L+r+ l +s
  EFC37199.1  79 WFQLAIFALCMVTSIICMSTYTTSGNLWcpnE--IvhairtllmKFYRLDANWKINMTslvFLIATIPITFLVSFVLKRFGLKWS 161
                 56677888999999999999999998776652..134566799977777766666555000555555677889999999998777 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 5.9e-05
     UPF0182 187 hlsvllallllllalsywLdryellyskrgvvtGagYtdvnavlpaktilavialvvavlllvai.vlkklklplialallvllaillg 274
                 +l  l  +++ll a   + + ++ +y  ++++ G +Yt +     +++il+v+a++ +++l + + ++k++kl++i + + ++la+l  
  EFC37199.1 365 KLIRLPSFFMLLAASTLINSFFQSIYILEQIIKGNKYTAIDSGN-LNIILIVFATISSIVLSILFdKTKQFKLITIITSASACLAFLWF 452
                 556666778888888888888899999999**********9865.66777777788888777777789999998888887777776433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (565 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1166  (0.0650343); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.44
# Mc/sec: 3861.92
//
Query:       EFC37200.1  [L=948]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00041   19.8   0.0     0.0012   18.3   0.0    1.7  1  START     START domain
  ------ inclusion threshold ------
      0.047   14.0   0.3      0.047   14.0   0.3    3.1  3  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   1.3e-07    0.0012      19     207 ..     712     922 ..     706     924 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 1.3e-07
                 TT-EEEEE.CCTTEEEEEEESSS-..SCEEEEEEEECCSCHHHHHHHHHCCCGGGTTCT-TT-SEEEEEEEECTT..........EEEEEEEE--TT.. CS
       START  19 egWvllvdsengdevlqkveeskv..ksgealraigvvdmvaallveellkdaeyraqWdktlasaetvevissg..........galqlyvaelvals 105
                   W l v +++++ + +k + + +     + ++ + + + ++ ++++++ ++  yr++ d+++ +++tv+ +++           +++ + + +l +  
  EFC37200.1 712 REWILAVNQKQYKCYFTKDKYDFGnsVGLKFFKFEILFPYNVKQVLKTFTNQE-YRQKIDEYIYDIQTVKYVEEPhiqtkdklftSVINHEKYKLIW-- 807
                 56888887777777777775543366677888888888888888888888877.9999999999999999888888889999999999999999999.. PP

                 -SS-EEEEEEEEEEE.TTS-EEE....EEEEEE-TTS--...........-TTSEE-EESSEEEEEEEECTCEEEEEEEEXEEXXSSXXHHHHHHHHHH CS
       START 106 plspRdfvflRsirelgdgsyvi....vdrSvtseqnppe..........sssvvRaellpSgilieplgnghskvtwvehvdlkgwlpkwllrslvks 190
                 p++ R+  +  s   ++   ++i     + S++ e np+           ++++++    + g  +e+l+++ +k++ ++ +d+kg++pk ++  ++ +
  EFC37200.1 808 PIKDREIIVCTSSVHDRVSNLYIigfkSCDSLCLEENPEHqlhnekqeksKKKIIK-ACVVGGWFFESLSENETKFHEIYYIDMKGSIPKLMMDKVITN 905
                 99999999988888877777666233335678777777655444435555667777.56789999********************************** PP

                 HHHHHHHHHHHHTXXXX CS
       START 191 glaegaktwvatlqrlc 207
                 +++++ k  ++ l++++
  EFC37200.1 906 RASKFYKLGLKYLKENE 922
                 *******9999999876 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.2     0.055     5e+02      30      93 ..     373     459 ..     367     466 .. 0.59
   2 ?   14.0   0.3   5.2e-06     0.047      70     118 .]     605     654 ..     589     654 .. 0.88
   3 ?   -3.4   0.1       1.2   1.1e+04      71      82 ..     764     775 ..     750     800 .. 0.41

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.055
                 HHHHHHHHHTS..............SHHHHHHHH....HHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.......STTTTTTHHH CS
         RGS  30 Fwlaveefkka..............keqeelkkk....akeIyneylapsspkelnidkklreelekrleke.......qpsrklfeea 93 
                 F+ ++e++k                +  +++++     + ++ ne++ +ss+k l++  + ++++ + +++           ++l++ +
  EFC37200.1 373 FFHDCEDLKILdlqgeqfedkiihqN-IQAIVNCkleeVLVMSNEFF-KSSKKTLELIAEKKAKIDTEFTETeiepilkPIGEDLYQFV 459
                 66777777766666776666666641.22222222333677788888.88888888888888888887777444444443444444444 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 5.2e-06
                 HHHHHHHHHHHCSS.STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS  70 kklreelekrleke.qpsrklfeeaqeevfellekdsypkFlkselylrl 118
                 kk+ ++ +k+++++  + ++lf +++  ++e l+ ++++ Flks+l++++
  EFC37200.1 605 KKTINSFKKCFQEHaDNPENLFRKVEMFIHESLKLNYFHGFLKSDLFHNY 654
                 67778888888776578899***************************975 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 1.2
                 HHHHHHHHHHCS CS
         RGS  71 klreelekrlek 82 
                 + r+++ +++ +
  EFC37200.1 764 EYRQKIDEYIYD 775
                 222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (948 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       751  (0.0418874); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.51
# Mc/sec: 5600.45
//
Query:       EFC37201.1  [L=477]
Description: hypothetical protein NAEGRDRAFT_59833 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.7e-14   51.6  21.1    3.7e-08   33.0   7.0    3.5  3  ZZ           Zinc finger, ZZ type
      2e-05   24.8  25.0      0.014   15.7   8.4    3.6  3  C1_2         C1 domain
    0.00079   19.3   0.1     0.0016   18.3   0.1    1.5  1  F-box-like   F-box-like
  ------ inclusion threshold ------
       0.85    9.2   6.0         13    5.4   0.2    3.3  3  Sgf11        Sgf11 (transcriptional regulation protein)


Domain annotation for each model (and alignments):
>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.22   9.8e+02       5      15 ..     162     170 ..     160     175 .. 0.77
   2 !   33.0   7.0   8.3e-12   3.7e-08       4      36 ..     250     281 ..     249     288 .. 0.91
   3 !   25.1   2.5   2.5e-09   1.1e-05       4      37 ..     316     348 ..     314     353 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.22
                 EE-TTT-S..E CS
          ZZ   5 ytCdgCseapl 15 
                 ++C +C++   
  EFC37201.1 162 VECAECGA--K 170
                 89****98..4 PP

  == domain 2  score: 33.0 bits;  conditional E-value: 8.3e-12
                 -EE-TTT-S..EESSEEEESSSSS-EE-HHHHH CS
          ZZ   4 kytCdgCseapligvRyhclrcsdYDLCqsCfs 36 
                 ++tCd+C e p+ g Ry cl c +YDLC  C  
  EFC37201.1 250 EFTCDICEE-PITGIRYNCLDCGEYDLCGYCCE 281
                 69*******.*******************9976 PP

  == domain 3  score: 25.1 bits;  conditional E-value: 2.5e-09
                 -EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH CS
          ZZ   4 kytCdgCseapligvRyhclrcsdYDLCqsCfst 37 
                  y+C+ C+e  + g Ry     +dYDLC  Cf +
  EFC37201.1 316 TYSCNACKE-KIRGYRYVDPEKDDYDLCTICFYK 348
                 79*******.**********************75 PP

>> C1_2  C1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.2     0.054   2.4e+02      10      46 ..     152     191 ..     147     192 .. 0.71
   2 !   15.7   8.4   3.1e-06     0.014      17      46 ..     249     279 ..     236     280 .. 0.86
   3 !   15.5   3.5   3.6e-06     0.016       3      46 ..     300     345 ..     299     346 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.054
        C1_2  10 s.kgedssesfnCsaCgrkidgff.YsCse.CdfslhvrC 46 
                 s  ge+ +   +C  Cg ki+  + Y+ ++    ++h++C
  EFC37201.1 152 StPGENGYWGVECAECGAKIEHREtYIWDKdSSDNFHIDC 191
                 555677888899*******977778987774345566666 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 3.1e-06
        C1_2  17 esfnCsaCgrkidgffYsCseC.dfslhvrC 46 
                  +f+C++C+++i+g +Y+C  C ++ l+  C
  EFC37201.1 249 PEFTCDICEEPITGIRYNCLDCgEYDLCGYC 279
                 469*******************77***9998 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 3.6e-06
        C1_2   3 HpHpLtls.kgedssesfnCsaCgrkidgffYsCse.CdfslhvrC 46 
                 HpH  +++ +ge+  ++++C+aC++ki g++Y  +e  d+ l+  C
  EFC37201.1 300 HPHDHIFQtIGEENFDTYSCNACKEKIRGYRYVDPEkDDYDLCTIC 345
                 777766666799********************99888999999988 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.1   3.6e-07    0.0016       9      43 ..      64      98 ..      62     103 .. 0.91

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 3.6e-07
  F-box-like  9 LlqIFsyLppsdLlr.lalVCrrWrrvaldtplLWr 43
                 l+++s+L+ +dL++ +  VC+ +r++al++  LW 
  EFC37201.1 64 FLRVLSFLDEYDLAQsIEPVCKLFRNFALSD-ALWE 98
                689************88**************.***7 PP

>> Sgf11  Sgf11 (transcriptional regulation protein)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.1      0.14   6.4e+02       5      14 ..     162     171 ..     161     173 .. 0.82
   2 ?    5.4   0.2    0.0029        13       3      19 ..     249     265 ..     247     271 .. 0.91
   3 ?    4.7   0.2     0.005        22       4      20 ..     316     332 ..     314     333 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.14
                 EE-TTTSSEE CS
       Sgf11   5 vtCpnCgRqi 14 
                 v+C  Cg +i
  EFC37201.1 162 VECAECGAKI 171
                 79****9777 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0029
                 -EEE-TTTSSEEEGGGH CS
       Sgf11   3 eyvtCpnCgRqiaasRF 19 
                 + +tC++C+ +i + R+
  EFC37201.1 249 PEFTCDICEEPITGIRY 265
                 78**********99998 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.005
                 EEE-TTTSSEEEGGGHH CS
       Sgf11   4 yvtCpnCgRqiaasRFA 20 
                 +++C+ C+ +i + R++
  EFC37201.1 316 TYSCNACKEKIRGYRYV 332
                 589**********9996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (477 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       969  (0.0540465); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 2801.67
//
Query:       EFC37202.1  [L=857]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      5e-17   62.2  16.4    1.3e-16   60.8  16.4    1.8  1  Ferric_reduct  Ferric reductase like transmembrane component
    4.9e-15   55.8   1.1      1e-10   41.9   0.1    3.1  3  DOMON          DOMON domain
    5.3e-13   49.4   0.4    2.5e-07   31.0   0.1    2.7  2  NAD_binding_6  Ferric reductase NAD binding domain
    1.2e-06   28.6   0.1    2.5e-06   27.5   0.1    1.5  1  FAD_binding_8  FAD-binding domain
    4.9e-06   27.2   0.0      1e-05   26.2   0.0    1.6  1  NAD_binding_1  Oxidoreductase NAD-binding domain
  ------ inclusion threshold ------
       0.12   12.0   0.0       0.19   11.4   0.0    1.2  1  PrkA           PrkA serine protein kinase C-terminal domain


Domain annotation for each model (and alignments):
>> Ferric_reduct  Ferric reductase like transmembrane component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.8  16.4   4.5e-20   1.3e-16       4     124 ..     441     557 ..     438     566 .. 0.89

  Alignments for each domain:
  == domain 1  score: 60.8 bits;  conditional E-value: 4.5e-20
  Ferric_reduct   4 aalillplallla..lRnnflepltglsldklllfHkwlgvlafllallHvilyllnflrfsaldeerlldsllkkpynllGvlalllliilaitS 97 
                    a++  +++ l+l   +R ++l+ l+g+s+d+++ +H+wlg+l ++++++H+i++++++ +     +  +l + ++ ++ +lG++a++++ il++++
     EFC37202.1 441 ASVCVFNFGLILFpvTRYSVLQVLFGISFDRAIKYHRWLGILQWFFVTAHGIAMVVHYNA-----SGLYLVDVTSPTFPILGIIAWFFMTILWLMT 531
                    5555666666633359****************************************9997.....47999999999******************** PP

  Ferric_reduct  98 lkfirrrlsyelFyylHhllyvaylll 124
                    +++ir r  +e+F+++H++l +++++l
     EFC37202.1 532 FPVIR-RKLWEVFLISHVILSILIVIL 557
                    *****.6667*********99988875 PP

>> DOMON  DOMON domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.0   9.5e-05      0.28      61     123 ..       2      62 ..       1      64 [. 0.82
   2 !   41.9   0.1   3.4e-14     1e-10      15     124 ..     167     278 ..     148     279 .. 0.81
   3 ?   -1.5   0.0      0.91   2.7e+03      81     103 ..     597     619 ..     594     625 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 9.5e-05
       DOMON  61 dyystggkgapriddtgsqditlls..gseengvttlkfrRkldtcdpkqdnkidldttvyviwa 123
                 d ++  + ++p++d   s+di + +  + +  g t++k +R ++t+d+ +d  + ++  ++  wa
  EFC37202.1   2 DAWMVAKPQSPVSDA--SDDILQRNggYNSATGETHIKWTRFVKTGDS-HDVIF-TNAVMKTSWA 62 
                 778666666699**5..5999999855666789**************9.**999.9999999998 PP

  == domain 2  score: 41.9 bits;  conditional E-value: 3.4e-14
       DOMON  15 gdeiefelsgkvnt.ngyvaiGfsd..dgkMsnadvvvgwvd.ngrvyvqdyystggkgapriddtgsqditlls....gseengvttlkfrRkldtcd 105
                    ief l   ++   gy +iGf +  +++M+ ad ++g+vd +g++ + d+y++g+ +ap++d++  qd+ + +      + n  ++lk +R ++t+d
  EFC37202.1 167 VPIIEFGLI--ATGiYGYASIGFNHgtNSGMDTADTMFGYVDsSGNPVILDTYMQGNLQAPTLDSS--QDFISKNgglrSVSGNYELHLKWTRLVNTKD 261
                 456888888..44349********998889************66********************77..66666553433455677899*********** PP

       DOMON 106 pkqdnkidldttvyviwaa 124
                 +  d+ + ++ ++++ wa+
  EFC37202.1 262 S-LDHLF-TNAQISISWAI 278
                 9.*****.*********97 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.91
       DOMON  81 itllsgseengvttlkfrRkldt 103
                 i ++ ++e++ vtt++ r+++ t
  EFC37202.1 597 IDSIKYDEKSQVTTITMRKPFLT 619
                 6788999************9866 PP

>> NAD_binding_6  Ferric reductase NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.1   8.2e-11   2.5e-07       1      88 [.     712     791 ..     712     793 .. 0.91
   2 !   17.4   0.1   1.2e-06    0.0037     113     154 ..     790     836 ..     784     837 .. 0.88

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 8.2e-11
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6   1 yenvllvagGiGitpfisilkdllkkskkealktkkikliwvvressslewfkdvLneleeeksegnieihiYlTseyeaedasdqli 88 
                    y+++++ +gGiGitp+ si  +ll+k      + k ++  w++  ++++++f    + le++ ++ n++ +i++++++e+++++ + i
     EFC37202.1 712 YKTIVMFGGGIGITPVHSIYSHLLEKNI----QDKTVYTCWSIPTTDMIQVFP---QLLETNGNK-NLKPNIFISKMKEENSQQTAFI 791
                    789*********************9986....999******************...777788888.*************999887765 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 1.2e-06
                    xxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6 113 kihfgRPnlkevlkdi.....askhknssvgvfvCGppklvkevkkl 154
                     ih gR n k+ l+++      + + n+ vgv+vCGp++lv  v+++
     EFC37202.1 790 FIHKGRANPKQFLEQVkkemkERGELNAYVGVLVCGPEQLVTSVSNA 836
                    5899************988877788899**************99885 PP

>> FAD_binding_8  FAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.1   8.5e-10   2.5e-06      14     107 ..     606     704 ..     595     706 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 8.5e-10
  FAD_binding_8  14 edliklkvskpkkslkyka..GqyvyinipslsklfwqsHPFtiasape.......ddklslvikvk...sgltkklakkllssskkelenkkakl 97 
                    +++ +++++kp  ++ +++  G +++++ip++sk+  q HP t+ s +e        ++l+  + vk   sg++k++ak   ++      +++++l
     EFC37202.1 606 SQVTTITMRKPFLTFGSNPsmGHFIFLYIPAVSKY--QHHPITVSSCKEidggmikKKELEFTVHVKnfgSGWSKQVAKIAQEK-----AQSANEL 694
                    6788999****99987765559***********77..*********99999888886666665555522369999999999888.....5778888 PP

  FAD_binding_8  98 kvlidGPYGa 107
                       ++G YG+
     EFC37202.1 695 ICRVEGAYGS 704
                    8888999996 PP

>> NAD_binding_1  Oxidoreductase NAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.0   3.3e-09     1e-05       1     108 [.     717     834 ..     717     835 .. 0.75

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 3.3e-09
                    EEEEGGGGHHHHHHHHHHHHHCTTCSEEEEEEEESSGCGSTTHHHHHHHHHHCTT..EEEEEEE.ESSCTTTSSSEESSHH.HHHHHHHHH..... CS
  NAD_binding_1   1 miagGtGiaPvrsvlraileeakdktkvvlvyGnrteedllyreeleelakklpg..rlkvvav.vsreeagweggkgrvq.dalleells..... 87 
                    m +gG Gi+Pv s+  ++le++ +++ v+  + ++t++ + +  +l e + +++   ++ + ++ +++ +++    kgr + +++le++ +     
     EFC37202.1 717 MFGGGIGITPVHSIYSHLLEKNIQDKTVYTCWSIPTTDMIQVFPQLLETNGNKNLkpNIFISKMkEENSQQTAFIHKGRANpKQFLEQVKKemker 812
                    889*****************9667799***********9998888888866655534554555565666666667777776233445554477667 PP

                    .HSSTTEEEEEECSHHHHHHHH CS
  NAD_binding_1  88 .lkkeethvyvCGppgMikavr 108
                       ++ + v+vCGp+++++ v+
     EFC37202.1 813 gELNAYVGVLVCGPEQLVTSVS 834
                    755888999********99886 PP

>> PrkA  PrkA serine protein kinase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   6.2e-05      0.19      37     102 ..     750     812 ..     749     816 .. 0.93

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 6.2e-05
        PrkA  37 ispRyvikilsealssseakeekcinpldvlealeeglkeheviseeerekyleflevvreeyder 102
                 i+++++i+++ ++l+++    +k ++p   ++ ++e  ++++ + ++ r+++++fle v++e++er
  EFC37202.1 750 IPTTDMIQVFPQLLETN---GNKNLKPNIFISKMKEENSQQTAFIHKGRANPKQFLEQVKKEMKER 812
                 7899*********9755...5999***************************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (857 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1049  (0.0585086); expected 358.6 (0.02)
Passed bias filter:                      574  (0.0320152); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.82u 0.39s 00:00:01.21 Elapsed: 00:00:00.56
# Mc/sec: 4635.84
//
Query:       EFC37203.1  [L=326]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (326 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       871  (0.0485805); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2094.38
//
Query:       EFC37204.1  [L=377]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-06   28.6   0.0     0.0022   18.6   0.0    2.7  3  RCC1         Regulator of chromosome condensation (RCC1) repe
  ------ inclusion threshold ------
      0.057   13.4   0.1       0.12   12.4   0.1    1.4  1  Adeno_GP19K  Adenovirus GP19K
       0.62    9.9   2.8        1.4    8.8   0.0    2.9  4  RCC1_2       Regulator of chromosome condensation (RCC1) repe


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.3   7.6e+03      38      48 ..     107     117 ..      74     119 .. 0.60
   2 !    7.2   0.0    0.0014       8.1       8      50 .]     130     177 ..     123     177 .. 0.66
   3 !   18.6   0.0   3.7e-07    0.0022       7      48 ..     186     227 ..     185     229 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.3
                 EEEEEETTEEE CS
        RCC1  38 vkvacGddhtv 48 
                  ++ +G+ ht 
  EFC37204.1 107 GSAYSGYGHTY 117
                 35556777775 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0014
                 E--GGGTTSSSS-...--EEEEEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   8 GrndyGqLGlgtt...esvlvPtkveglsgn..rvvkvacGddhtval 50 
                 G+    q   +++   ++ ++P++++++  +   v+ +a+G+ +++++
  EFC37204.1 130 GNTGLAQFAKQPSdseHDIHTPVEIASPLVKgkSVKLIASGYAYCIVI 177
                 544444555566643355599****666555559999*****999876 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 3.7e-07
                 EE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEE CS
        RCC1   7 WGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtv 48 
                 +G+ndy qLG  t ++   P+ ++ +++ +++++++G+  ++
  EFC37204.1 186 FGSNDYQQLGYATPNKIYDPMPLTVPTNSKIKAISAGQWVSL 227
                 9*************999889999999888********99886 PP

>> Adeno_GP19K  Adenovirus GP19K
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1     2e-05      0.12      34      78 ..     307     355 ..     298     363 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2e-05
  Adeno_GP19K  34 gkyavyaiwqpg.dtndynvtvfqgedr..kvflykfpf.yemcditmy 78 
                   ky vy     g  t dynv  ++ e++    f+ykf    ++cd+t+ 
   EFC37204.1 307 VKYRVYPSVISGnGTADYNVLFYEDENNvgTHFIYKFNEkTDLCDVTII 355
                  6999997655551589*******99886335799**975268****975 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0      0.86   5.2e+03      10      17 ..      44      51 ..      43      53 .. 0.82
   2 ?   -1.8   0.0       0.5     3e+03       6      15 ..     111     120 ..     108     131 .. 0.66
   3 ?   -0.8   0.0      0.24   1.4e+03       4      30 .]     167     193 ..     164     193 .. 0.60
   4 ?    8.8   0.0   0.00024       1.4       1      25 [.     216     240 ..     216     243 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.86
      RCC1_2 10 HscaLted 17
                H++++t+d
  EFC37204.1 44 HYVSVTDD 51
                99999997 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.5
      RCC1_2   6 aGdyHscaLt 15 
                 +G+ H+ ++t
  EFC37204.1 111 SGYGHTYFVT 120
                 7999976655 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.24
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +++G+   +++ ed+  + +GsN++ Q
  EFC37204.1 167 IASGYAYCIVIFEDDSGVVFGSNDYQQ 193
                 566665555555555556788887755 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.00024
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGs 25 
                 +k++saG   s++ te++e++ +G+
  EFC37204.1 216 IKAISAGQWVSLICTENNELYITGN 240
                 799********************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       463  (0.0258241); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 2417.85
//
Query:       EFC37205.1  [L=861]
Description: regulator of chromosome condensation family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.1e-07   29.6   0.0      0.075   12.9   0.0    3.5  3  RCC1_2         Regulator of chromosome condensation (RCC1) re
    2.3e-05   24.9   0.2    0.00013   22.5   0.1    2.4  3  RCC1           Regulator of chromosome condensation (RCC1) re
  ------ inclusion threshold ------
      0.029   14.0   0.0      0.091   12.4   0.0    1.8  1  Lactamase_B_4  tRNase Z endonuclease


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0       0.1   6.1e+02      18      29 ..      86      97 ..      76      98 .. 0.82
   2 !   12.9   0.0   1.2e-05     0.075       7      26 ..     230     249 ..     224     253 .. 0.93
   3 !   11.5   0.0   3.4e-05       0.2       2      21 ..     281     300 ..     281     304 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.1
      RCC1_2 18 GeVlcWGsNsdG 29
                ++V+ +G+N++ 
  EFC37205.1 86 NIVFVTGRNTNT 97
                56*******975 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 1.2e-05
      RCC1_2   7 GdyHscaLtedGeVlcWGsN 26 
                 G+++++++te++ ++++G+N
  EFC37205.1 230 GADFAFFITESNQLYAFGQN 249
                 99*****************9 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 3.4e-05
      RCC1_2   2 ksvsaGdyHscaLtedGeVl 21 
                 ++v++G+ H++ +te G+++
  EFC37205.1 281 VKVACGSQHTILVTEQGNIY 300
                 68***************987 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.1   6.8e+03       4      15 ..      88      99 ..      87      99 .. 0.91
   2 ?   -2.5   0.0       1.4   8.6e+03      36      50 .]     223     237 ..     209     237 .. 0.76
   3 !   22.5   0.1   2.2e-08   0.00013       3      49 ..     242     292 ..     240     293 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.1
                EEEEE--GGGTT CS
        RCC1  4 VysWGrndyGqL 15
                V+  Grn++ q+
  EFC37205.1 88 VFVTGRNTNTQC 99
                8999*****998 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.4
                 -EEEEEEETTEEEEE CS
        RCC1  36 rvvkvacGddhtval 50 
                 ++ ++  G+d+ +++
  EFC37205.1 223 KIESIHNGADFAFFI 237
                 899999*****9987 PP

  == domain 3  score: 22.5 bits;  conditional E-value: 2.2e-08
                 EEEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS.....-EEEEEEETTEEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt.esvlvPtkveglsgn.....rvvkvacGddhtva 49 
                 ++y++G+n + qL +++  +++  P k +  ++      r vkvacG++ht++
  EFC37205.1 242 QLYAFGQNLQKQLSIPNCsHTE--PCKAQQVTSSlfhneRPVKVACGSQHTIL 292
                 79************98776777..*66655555555688************87 PP

>> Lactamase_B_4  tRNase Z endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.5e-05     0.091      12      44 ..     181     213 ..     177     217 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.5e-05
  Lactamase_B_4  12 gPlllLqldskrYlfGkvgEgtQRavneqkvrl 44 
                    g+++l ++ds+ Y++G+vg+g+Q + + +k++l
     EFC37205.1 181 GTMILNECDSQVYIIGDVGDGIQSVETLSKISL 213
                    6889999****************9999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (861 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       509  (0.0283898); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 5270.41
//
Query:       EFC37206.1  [L=828]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.8e-21   75.0   4.6    1.5e-20   73.7   2.3    2.5  2  Pkinase        Protein kinase domain
    2.7e-15   56.4   0.4    5.1e-15   55.4   0.4    1.4  1  Pkinase_Tyr    Protein tyrosine kinase
    6.2e-09   35.8  11.0    6.2e-09   35.8  11.0    2.8  2  HECT           HECT-domain (ubiquitin-transferase)
  ------ inclusion threshold ------
      0.027   13.8   0.0      0.067   12.5   0.0    1.6  1  Kdo            Lipopolysaccharide kinase (Kdo/WaaP) family
      0.045   13.6   3.7        1.3    8.9   0.3    2.7  2  Tho1_MOS11_C   Tho1/MOS11 C-terminal domain
      0.063   13.7   8.6      0.044   14.3   2.5    3.3  3  NPV_P10        Nucleopolyhedrovirus P10 protein
      0.071   13.0   0.0       0.13   12.2   0.0    1.3  1  APH            Phosphotransferase enzyme family
       0.54   10.7  20.3        1.5    9.3   2.9    4.3  4  FlaC_arch      Flagella accessory protein C (FlaC)
        0.8    9.0  11.6      0.098   11.9   4.9    2.5  2  DUF3450        Protein of unknown function (DUF3450)
          2    7.1  14.0        3.5    6.3  14.0    1.2  1  Caldesmon      Caldesmon
        2.2    8.5  21.1        3.9    7.7   5.9    2.8  2  Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
        2.2    8.9  10.7        2.4    8.8   1.2    4.2  4  SlyX           SlyX
        2.3    7.5   5.3        3.9    6.8   5.3    1.3  1  DUF4407        Domain of unknown function (DUF4407)
        2.6    8.3  24.2      0.038   14.2   8.8    3.6  3  Seryl_tRNA_N   Seryl-tRNA synthetase N-terminal domain
        3.3    7.8  14.0        3.1    7.8   7.3    3.2  2  DUF1664        Protein of unknown function (DUF1664)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.7   2.3   1.2e-23   1.5e-20      13     136 ..     250     380 ..     239     384 .. 0.89
   2 ?   -0.0   0.0      0.38   4.6e+02     233     249 ..     719     745 ..     648     753 .. 0.73

  Alignments for each domain:
  == domain 1  score: 73.7 bits;  conditional E-value: 1.2e-23
                 EEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHH.....HHSS--HHHHHHH CS
     Pkinase  13 GkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee..kdelylvleyveggeladlle.....rkgslseeeakki 103
                 ++Vyk   k++++ v +K+i+ ++ ++++ +++++Ei  + +lk h++i++l +vf e   +++y+ + y ++g+l ++++     ++++  +  ++++
  EFC37206.1 250 SVVYKSS-KSNNQVVILKEISLSQSTDNNCDAIMNEIMNIVRLKvHSRIIKLNGVFIEpnFNKIYIETPYYSNGNLLEYVNkikpqHDTKTLKIMLRSL 347
                 6899988.799*********************************************9977789************99999966553223344448899* PP

                 HHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE CS
     Pkinase 104 akqilegleylHskgiiHrDlKpeNiLidekge 136
                 +++i e l+++Hsk i+HrDlKp+NiL++e+g+
  EFC37206.1 348 FRKITETLQFIHSKDILHRDLKPQNILVNENGD 380
                 *****************************8875 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.38
                 S..........-HHHHHHHHHHT-SSG CS
     Pkinase 233 i..........seeakdllkkllkkdp 249
                 +          se++kd+l+k+++k  
  EFC37206.1 719 LllneinfyfvSETMKDFLTKCIRKLT 745
                 0444445566699*********98755 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.4   0.4   4.3e-18   5.1e-15      13     140 ..     243     379 ..     239     407 .. 0.83

  Alignments for each domain:
  == domain 1  score: 55.4 bits;  conditional E-value: 4.3e-18
                  EEEEEEEEET..TTTSSEEEEEEEEE.STTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHT...CTTTSB CS
  Pkinase_Tyr  13 GkVvegtlkg..ekekkevkVavKtl.keeateeekeelleeakimkkl.khpnivkllgvct..keepllivteyvkgGdLlkfLrkk...ekeklt 101
                  G+V++g      +++++++ V++K +  +++t+++ +++++e+  + +l  h +i+kl gv +  + ++++i t y ++G+Ll++++k    +++k+ 
   EFC37206.1 243 GTVHSGLSVVykSSKSNNQVVILKEIsLSQSTDNNCDAIMNEIMNIVRLkVHSRIIKLNGVFIepNFNKIYIETPYYSNGNLLEYVNKIkpqHDTKTL 340
                  77777766555477778888999*9944677777799************99************776778*****************997332222222 PP

                  HHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETT CS
  Pkinase_Tyr 102 lkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenk 140
                     l s+  ++ + +++++sk+++Hrdl  +N+L++en 
   EFC37206.1 341 KIMLRSLFRKITETLQFIHSKDILHRDLKPQNILVNENG 379
                  2345577899**************************975 PP

>> HECT  HECT-domain (ubiquitin-transferase)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   1.2       2.4   2.9e+03      76     103 ..     153     180 ..      52     220 .. 0.64
   2 !   35.8  11.0   5.2e-12   6.2e-09      22     283 ..     499     796 ..     481     809 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.4
                 -TCHHHHH-HHHHHHHHHHH..HS-GGG CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT  76 tledleeidpelakslkellslesntee 103
                 + ed+e ++++l +  k++++l+++++e
  EFC37206.1 153 NNEDIERLEKKLSEMGKKISELNEQKTE 180
                 2244555555555555555555555544 PP

  == domain 2  score: 35.8 bits;  conditional E-value: 5.2e-12
                 SSSEEE-TTHHHHS...............HHHHHHHHHHHHHT..T--BSS-B-HHHHHHHTT......-.---TCH........HHHH-HHHHHHHHH CS
                 xxxxxxxxxxxxxx...........xxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxx......xxxxxxxx........xxxxxxxxxxxxxx RF
        HECT  22 sgtlypkpssseee...........llklfeflGkvlGkaiye..eilldlpfsraflkfllg......eekitled........leeidpelakslke 93 
                 s+ ++ +++ss+e+            + + + +G +l k +++  + ++ lp++++++++ll+      ++ ++++d        l+e+d el +++ +
  EFC37206.1 499 SKHFQKSETSSNENfiltdepltdeSRIQLKAFGWLLKKLLIDcdDKTVYLPLNSFIFYYLLNgdiiykKQALHINDmiltlskfLREYDFELDNQIMN 597
                 3333334444444466666777777556799**********99889*****************9***998899999999999999************** PP

                 HH..HS-GGG...GT-..BSEEEEETTEEEEEESSTTGGGSB--TTTHHHHH..................................HHHHHHHHTGGGH CS
                 xxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................................xxxxxxxxxxxxx RF
        HECT  94 llslesnteevedlaL..tFtipenagasatieLipnGanipVtnenkkeYi..................................klyvnyllkksve 156
                 l+++++++ e++++a   tFt           + ++  ++ p+  +n+++Yi                                  +      l  s+ 
  EFC37206.1 598 LRKCKNDK-ELQSIAYeeTFT-----------DVLS-KTEKPLIMDNIHLYIisqlhpyfysairmeklklikegfdwfnlkqfktQ------LICSFS 677
                 **998877.588887766777...........2233.35678888999999977777777777777777777777776664332222......223333 PP

                 HHHHHHHHHHHTTS.-HHHHTTS-HHHHHHHHBCSSS.--HHHHHHTEEEETT--TTSHHHHHHHHHHHHS-HHHHHHHHHHHHSSSS--TTCGGG-B- CS
                 xxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT 157 kqleaflkGfsevi.pskalklfdaeelellisGedelidvedlrrnteykggynaesetiewlweilkefspeekrlfLqFvTgssrlPlgGfaelhp 254
                   +e+ l+ f ++  p+   + ++ +el+ l+sG++  id + l + +++   y  ++++ + l++ ++++++++ r++L ++T+ s++P+ Gf+   +
  EFC37206.1 678 ISTESELREFFHLQgPNFVEQDLSVNELKILLSGQS-YIDDDLLLNEINF---YFVSETMKDFLTKCIRKLTNSQLRQLLVWMTALSSIPIRGFS---R 769
                 333333333333432555556778888888888888.4888888888775...667779999999*****************************9...7 PP

                 -EEEEE-S..-TTS--EEEGGGTEEEE-....- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx....x RF
        HECT 255 kftierkskedetrLPtahTCfnlLklp....d 283
                 k+ i+ ++     r   ahTC   +++p     
  EFC37206.1 770 KISIREQK-----R-FEAHTCSFSFDIPsqitT 796
                 89998854.....3.479***999999953333 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   5.6e-05     0.067     119     155 ..     343     379 ..     328     393 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.6e-05
         Kdo 119 lkrallkavgrliaklhragvnHadlyaknillqqee 155
                 + r l++++  + + +h+ ++ H+dl ++nil+++++
  EFC37206.1 343 MLRSLFRKITETLQFIHSKDILHRDLKPQNILVNENG 379
                 5578899**************************9987 PP

>> Tho1_MOS11_C  Tho1/MOS11 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.3     0.021        25      27      41 ..      20      34 ..      17      35 .. 0.85
   2 ?    8.9   0.3    0.0011       1.3      12      36 ..     140     164 ..     138     168 .. 0.94

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.021
  Tho1_MOS11_C 27 eaidelekqleRieK 41
                  ++i  l+k+l+RieK
    EFC37206.1 20 QTIHLLKKELNRIEK 34
                  567889*******99 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0011
  Tho1_MOS11_C  12 LekklkRakKFgqeeeaidelekql 36 
                   L+ k+ R++K g+++e+i++lek+l
    EFC37206.1 140 LQIKKLRKNKIGTNNEDIERLEKKL 164
                   789999*****************99 PP

>> NPV_P10  Nucleopolyhedrovirus P10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0       1.3   1.5e+03      27      55 ..      12      40 ..       4      49 .. 0.77
   2 ?   -0.1   0.1       1.1   1.3e+03      12      42 ..      79     109 ..      72     120 .. 0.77
   3 ?   14.3   2.5   3.7e-05     0.044       6      72 ..     121     194 ..     119     197 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 1.3
     NPV_P10 27 vddvqenlpdvtelnekLdaqsaqLaele 55
                v ++ +  ++++ l+++L+++ +q+ e++
  EFC37206.1 12 VVRIPKSAQTIHLLKKELNRIEKQISEMS 40
                56677888899999999999999988775 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 1.1
     NPV_P10  12 dikavddkVdalqqqvddvqenlpdvtelne 42 
                 d k++ ++V+ +++++ + ++nl+ ++++n+
  EFC37206.1  79 DNKELLEQVERMEDNIRENATNLECFQNINK 109
                 5567778888888888888888888888875 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 3.7e-05
     NPV_P10   6 LlvIradikavddkVdalqqqv.....ddvqenlpdvtelnekLdaqsaqLaeletkvenIqdiLnpde..vPd 72 
                 L +I++di ++d   d +  q+     +++ +n +d++ l++kL ++ +++ el+++ ++I++ L + +   P+
  EFC37206.1 121 LALIKDDIDEIDLEKDEIGLQIkklrkNKIGTNNEDIERLEKKLSEMGKKISELNEQKTEIEQNLMELIstFPE 194
                 789*******************6666666677899**************************9988743344565 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   0.00011      0.13     139     184 ..     335     379 ..     317     383 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00011
                 CCTCCHHHHHHHHHHHHHHHH--SSS-EEEE-SS-SGGGEEEC..T CS
         APH 139 selldlleeleeqvlaalaallpgelptvllHgDlhpgNllvdpdd 184
                 ++++  l  + + + +++ ++l+   ++ +lH+Dl+p+N+lv++++
  EFC37206.1 335 HDTKT-LKIMLRSLFRKITETLQFIHSKDILHRDLKPQNILVNENG 379
                 33333.55666668888888888878899**************443 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1      0.14   1.7e+02      10      34 ..      16      40 ..      11      47 .. 0.76
   2 ?    8.9   0.6    0.0016       1.9       9      39 ..      66      96 ..      63      97 .. 0.91
   3 ?   -0.9   0.3       1.9   2.3e+03      15      27 ..     120     132 ..     100     147 .. 0.50
   4 ?    9.3   2.9    0.0013       1.5       2      42 ..     150     190 ..     149     195 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.14
   FlaC_arch 10 sklsteletvkkeneelsksveelk 34
                +k   ++  +kke++ ++k++ e+ 
  EFC37206.1 16 PKSAQTIHLLKKELNRIEKQISEMS 40
                5666677888888888888888774 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0016
   FlaC_arch  9 lsklsteletvkkeneelsksveelkenVkd 39
                + + s +l+   k+n+el ++ve++++n+++
  EFC37206.1 66 ITNYSGKLSEFDKDNKELLEQVERMEDNIRE 96
                5678999**********************85 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 1.9
   FlaC_arch  15 eletvkkeneels 27 
                 +l+ +k++++e+ 
  EFC37206.1 120 SLALIKDDIDEID 132
                 4444444444444 PP

  == domain 4  score: 9.3 bits;  conditional E-value: 0.0013
   FlaC_arch   2 idelEnklsklsteletvkkeneelsksveelkenVkdlls 42 
                 i++  +++++l+ +l+ + k+++el+++ +e+++n  +l+s
  EFC37206.1 150 IGTNNEDIERLEKKLSEMGKKISELNEQKTEIEQNLMELIS 190
                 5555689999999*********************9999986 PP

>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.39   4.6e+02      71      98 ..      19      46 ..      13      51 .. 0.78
   2 ?   11.9   4.9   8.2e-05     0.098      17     116 ..     106     206 ..      97     207 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.39
     DUF3450 71 erlvasqeqeiasleeqieeieeierel 98
                ++ +  +++e++++e+qi+e+++ e+++
  EFC37206.1 19 AQTIHLLKKELNRIEKQISEMSACEKSV 46
                5667778899999999999999888776 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 8.2e-05
     DUF3450  17 tldqalkeaekavaaaaqsqkkidklddekqellaeyralkeeleslevy.neqlerlvasqeqeiasleeqieeieeierelvpllekmidrLeqfve 114
                 ++++++ +++   ++ a +   id++d ek+e+  ++++l++ +  ++ +  e+le+ ++++ ++i++l+eq++eie+  +el   + ++i +++q  +
  EFC37206.1 106 NINKLKLKKKDLLKSLALIKDDIDEIDLEKDEIGLQIKKLRKNKIGTNNEdIERLEKKLSEMGKKISELNEQKTEIEQNLMELISTFPEIIVEMKQPLT 204
                 566777778888888899999*******************99988876542899*****************************9999999999999777 PP

     DUF3450 115 ld 116
                 +d
  EFC37206.1 205 AD 206
                 66 PP

>> Caldesmon  Caldesmon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  14.0    0.0029       3.5     160     290 ..      54     183 ..      17     190 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0029
   Caldesmon 160 aeeeaeeeeeekkvdesedkevseelkde..............eskqvleekkaieeskkqngaeeeveaalkktkktertlseasan..aedeedeea 242
                                     e+++ ++de              ++k++le+  ++e++ ++n+ + e  ++++k+k +++ l +++a   ++ +e + +
  EFC37206.1  54 LT------------------EERDRIRDEiitnysgklsefdkDNKELLEQVERMEDNIRENATNLECFQNINKLKLKKKDLLKSLALikDDIDEIDLE 134
                 22..................2222222224444577777777788****************99999999999999999999888777633444455567 PP

   Caldesmon 243 kleaekkleelkrrrdekeseefeklrqkqqeaeveleelkkkree.rr 290
                 k e + ++++l++ +  +++e++e+l +k  e    + el++++ e ++
  EFC37206.1 135 KDEIGLQIKKLRKNKIGTNNEDIERLEKKLSEMGKKISELNEQKTEiEQ 183
                 889999******************************99*9999887344 PP

>> Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   9.5     0.054        64      49     144 ..      19     118 ..      12     131 .. 0.58
   2 ?    7.7   5.9    0.0033       3.9      90     152 ..     134     190 ..     111     192 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.054
  Jnk-SapK_ap_N  49 eaeleelreeleqLeteyerekelrkrae....eeleeie..dqweeer.kelqekveqleeenrelelkaknaadqlsrleekeaelkkeysklh 137
                     +++ +l++el+++e++ ++  + +k  e       +++e  d +++e   +++ k+++ +++n+el        +q++r+e++  e  ++ +  +
     EFC37206.1  19 AQTIHLLKKELNRIEKQISEMSACEKSVEfkelY--LLTEerDRIRDEIiTNYSGKLSEFDKDNKELL-------EQVERMEDNIRENATNLECFQ 105
                    5678889999999999999988888888875331..22221123333321345667777777777777.......666666666555544443333 PP

  Jnk-SapK_ap_N 138 e......retell 144
                    +      ++++ll
     EFC37206.1 106 NinklklKKKDLL 118
                    3323333333333 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0033
  Jnk-SapK_ap_N  90 erkelqekveqleeenrelelkaknaadqlsrleekeaelkkeysklheretellkklkelve 152
                    e+ e+  ++++l+++      k+   ++ ++rle+k +e+ k+ s+l+e++te+ ++l+el+ 
     EFC37206.1 134 EKDEIGLQIKKLRKN------KIGTNNEDIERLEKKLSEMGKKISELNEQKTEIEQNLMELIS 190
                    455555555555554......444559*********************************985 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.21   2.5e+02      30      52 ..      19      41 ..      15      50 .. 0.82
   2 ?    0.7   0.0       0.7   8.4e+02      26      55 ..      66      95 ..      61     104 .. 0.54
   3 ?    8.8   1.2     0.002       2.4       3      36 ..     155     188 ..     153     201 .. 0.83
   4 ?   -1.6   0.2       3.8   4.5e+03      14      45 ..     572     603 ..     569     615 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.21
                HHHHHHHHHHHHHHHHT-XXXXX CS
        SlyX 30 qqqidrlqrqlrllaerlkelee 52
                +q+i  l+++l++++++++e+++
  EFC37206.1 19 AQTIHLLKKELNRIEKQISEMSA 41
                68899999999999999998876 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.7
                HHHHHHHHHHHHHHHHHHHHT-XXXXXXXX CS
        SlyX 26 vaeqqqqidrlqrqlrllaerlkeleessg 55
                +++   ++++  +  ++l e+++ +e++ +
  EFC37206.1 66 ITNYSGKLSEFDKDNKELLEQVERMEDNIR 95
                444555555555555555555555554433 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.002
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        SlyX   3 erleeLEiklafqedtieeLndvvaeqqqqidrl 36 
                 e +e+LE kl+ + + i eLn++ +e +q + +l
  EFC37206.1 155 EDIERLEKKLSEMGKKISELNEQKTEIEQNLMEL 188
                 7799999999999999999999999888887766 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 3.8
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        SlyX  14 fqedtieeLndvvaeqqqqidrlqrqlrllae 45 
                 +  d+i +L++ + e + ++d +   lr+ ++
  EFC37206.1 572 HINDMILTLSKFLREYDFELDNQIMNLRKCKN 603
                 77899999999999999999988877777655 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   5.3    0.0032       3.9     118     237 ..      56     189 ..      25     201 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0032
     DUF4407 118 eeakelkeqlaaaltaelaeleaqiaalqaeidaaearldalraeaqkeldgtk.....gtgttgvaGkgpaakekkaqldaaqaelaelkakld.... 207
                 ee +++++++ ++++ +l+e ++++++l ++++  e+ ++++ +++++  + +k     ++  +  a   +  +e + + d++  ++++l+++      
  EFC37206.1  56 EERDRIRDEIITNYSGKLSEFDKDNKELLEQVERMEDNIRENATNLECFQNINKlklkkKDLLKSLALIKDDIDEIDLEKDEIGLQIKKLRKNKIgtnn 154
                 556666777777799999********9999999999999999999998877766666654444555555566666666666666666666666448866 PP

     DUF4407 208 .....atarlaalraelaeleaerakeraasqaaa 237
                       +++l++  ++++el++++++++++  + +
  EFC37206.1 155 edierLEKKLSEMGKKISELNEQKTEIEQNLMELI 189
                 66666556666666666666666666555555544 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   4.2       1.2   1.4e+03      47     101 ..      24      84 ..      16     103 .. 0.55
   2 ?    1.1   6.0      0.37   4.5e+02      29      99 ..      71     144 ..      51     145 .. 0.70
   3 ?   14.2   8.8   3.1e-05     0.038      44     107 ..     127     195 ..     117     196 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.2
                   HHHHHHHHHHHHCCCCCCTT.....S-TCCCCCCCHHHHHHH.HHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  47 elqaerNelskeIgkakkkk.....edaeeliaevkelkeel.kaleaelkeleaelekll 101
                    l++e N++ k+I+++++ +     ++   l +e + + +e+  +++ +l+e +++ ++ll
    EFC37206.1  24 LLKKELNRIEKQISEMSACEksvefKELYLLTEERDRIRDEIiTNYSGKLSEFDKDNKELL 84 
                   5777777777777777665545555444444444444444431223334444444433333 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.37
                   HHHHHHHHHHHHHHHHHHHHHH..HHHHHHHHCCCCCCTT.S-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  29 delleldekrrelqveleelqa..erNelskeIgkakkkk.edaeeliaevkelkeelkaleaelkeleaelek 99 
                    +l e d+  +el  ++e +    + N+ + e  + ++k   ++++l+++ + +k+++++++ e +e+  +++k
    EFC37206.1  71 GKLSEFDKDNKELLEQVERMEDniRENATNLECFQNINKLkLKKKDLLKSLALIKDDIDEIDLEKDEIGLQIKK 144
                   57888999999999999988661144555544333333323566789999999999999999999988777665 PP

  == domain 3  score: 14.2 bits;  conditional E-value: 3.1e-05
                   HHHHHHHHHHHHHHHCCCCCCTT.....S-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCTS--- CS
  Seryl_tRNA_N  44 eleelqaerNelskeIgkakkkk.....edaeeliaevkelkeelkaleaelkeleaeleklllaiPNi 107
                   +++e+  e+ e++ +I+k+ k+k     ed+e+l ++ +e+++++++l+++ +e+e++l +l+++ P i
    EFC37206.1 127 DIDEIDLEKDEIGLQIKKLRKNKigtnnEDIERLEKKLSEMGKKISELNEQKTEIEQNLMELISTFPEI 195
                   6788888999********************************************************987 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   1.2      0.14   1.7e+02      83     117 ..      59      94 ..      15     100 .. 0.61
   2 ?    7.8   7.3    0.0026       3.1      39     122 ..      90     176 ..      88     183 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.14
     DUF1664  83 keikee.vtevredlseigedvesvkeavegleskl 117
                   i++e +t+ +++lse+++d +++ e ve +e ++
  EFC37206.1  59 DRIRDEiITNYSGKLSEFDKDNKELLEQVERMEDNI 94 
                 344444145666777777777777777777777666 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0026
     DUF1664  39 lsdavesvskqleqvs..eslaatkrhLssridrvdkkldeqkeiskeikeevtevre.dlseigedvesvkeavegleskleriee 122
                 ++d + + +++le ++  ++l+  k++L + ++ + + +de    + ei  +++++r+ ++ + +ed+e +++  +++++k+++++e
  EFC37206.1  90 MEDNIRENATNLECFQniNKLKLKKKDLLKSLALIKDDIDEIDLEKDEIGLQIKKLRKnKIGTNNEDIERLEKKLSEMGKKISELNE 176
                 66666666777776654489999*********************************8725888999*****************9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (828 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1910  (0.106531); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.90u 0.36s 00:00:01.26 Elapsed: 00:00:00.56
# Mc/sec: 4419.44
//
Query:       EFC37207.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.5   1.7       0.16   12.0   1.7    1.3  1  DUF3275   Protein of unknown function (DUF3275)


Domain annotation for each model (and alignments):
>> DUF3275  Protein of unknown function (DUF3275)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   1.7   8.7e-06      0.16      74     154 ..     154     237 ..     130     257 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 8.7e-06
     DUF3275  74 legltlsgidklsrdearslalqevDPlde...eaaqpaaaapaapakaksspakaassk.dplvdtepfGvdapapapvaaegk 154
                 +e++  +++d+++ ++a++l+ ++  P  +    +++ ++ +p++  k  ++p + +++k ++++++e + + ++   + aa+++
  EFC37207.1 154 VEEMERKKLDDFAGEQADDLNDKDFTPTGSvepAKQKRTPRTPKKGVKRAAKPSPSQTKKkSKVIEDE-YSSSSSDGFESAASNS 237
                 67888889999999999999999999965511145557788888888899999999987525677665.3333333333333322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       757  (0.0422221); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1682.98
//
Query:       EFC37208.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.067   12.9   0.8      0.098   12.4   0.2    1.5  2  Baculo_19       Baculovirus 19 kDa protein conserved region


Domain annotation for each model (and alignments):
>> Baculo_19  Baculovirus 19 kDa protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0      0.62   1.1e+04      76      92 ..      82      97 ..      74     106 .. 0.56
   2 ?   12.4   0.2   5.5e-06     0.098      15      76 ..     184     246 ..     177     259 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 0.62
   Baculo_19 76 vainrdtikdisetGiy 92
                 ++++++i+ +s+  +y
  EFC37208.1 82 KKFSQNEISCMSQ-PEY 97
                3566666666665.333 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 5.5e-06
   Baculo_19  15 frntllyGaevevydldaeasierlflvkPenvllyntagtlYvYle.sasgvfCakneqavv 76 
                 ++ + ++ aev+  + +++ + e + l  P++  +ynt+++ YvY+e +  g +    e++++
  EFC37208.1 184 TNSSSTFMAEVNTTEVETPFENEDIDLNDPDECPIYNTKRACYVYFEeEVLGNVIELSENSLI 246
                 67778899**************************************94444555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1205  (0.0672095); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1615.78
//
Query:       EFC37209.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      1e-44  152.9   0.0    1.4e-44  152.5   0.0    1.1  1  Abhydrolase_2  Phospholipase/Carboxylesterase
    1.1e-08   34.6   0.0     0.0047   16.2   0.0    3.2  3  Hydrolase_4    Serine aminopeptidase, S33
    6.4e-05   23.7   0.0    0.00032   21.4   0.0    1.8  2  Abhydrolase_6  Alpha/beta hydrolase family
    0.00015   21.7   0.0     0.0011   18.9   0.0    2.0  2  Abhydrolase_3  alpha/beta hydrolase fold
    0.00021   20.8   0.6        0.2   11.1   0.0    2.6  3  Peptidase_S9   Prolyl oligopeptidase family
    0.00051   19.8   0.0     0.0037   17.0   0.0    2.2  1  FSH1           Serine hydrolase (FSH1)
    0.00084   18.4   0.6     0.0013   17.8   0.0    1.5  2  Asp2           Accessory Sec system GspB-transporter
     0.0012   18.5   0.0     0.0022   17.6   0.0    1.4  1  DLH            Dienelactone hydrolase family
     0.0054   16.2   0.0      0.086   12.3   0.0    2.1  2  Esterase_phd   Esterase PHB depolymerase
     0.0069   16.1   0.7       0.47   10.0   0.4    2.7  2  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.052   12.2   0.0      0.095   11.3   0.0    1.4  1  AXE1           Acetyl xylan esterase (AXE1)
        0.1   12.2   0.0       0.18   11.4   0.0    1.3  1  DUF2974        Protein of unknown function (DUF2974)


Domain annotation for each model (and alignments):
>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  152.5   0.0   9.6e-48   1.4e-44      10     216 ..      78     303 ..      71     304 .. 0.87

  Alignments for each domain:
  == domain 1  score: 152.5 bits;  conditional E-value: 9.6e-48
                    SS---EEEEEE--TT--SHHHHHHHH.TT...--TTEEEEEE---EEE-GGGTT-EEE-SS-B--SSTTS...-B-HHHHHHHHHHHHHHHHHHHH CS
  Abhydrolase_2  10 kdkaqavviflHGlGdsghawaeaaktea...alpnikfifphgpelpvtlnggmrmpaWfdlvglspek...kedeagikksaekleelidaelk 99 
                    +d ++a++iflHG Gd+ ++w++ +  +    ++++ kf +p++p++p  l  gm   +W+++ +l+ e    +ed   +++ +ek+ +lid e++
     EFC37209.1  78 GDSHNATMIFLHGFGDQSDGWSQTFDRFLsdeKFKKLKFLVPNAPSQPISLGFGMSFKSWYNVKSLAVEGpdvNEDVPSMEACFEKITQLIDREIN 173
                    6889**************9999887754322289999*****************************99887557777789999************9 PP

                    T.T--GGGEEEEEETHHHHHHHHHHHT-SS--SEEEEES---TTGGGTTTTS-GGG.....GG-EEEEEEETT-SSS-HHHHHHHHHHHHTTS-.. CS
  Abhydrolase_2 100 k.gipssriiigGFSqGaalalylaltlpkklggivafsgalplsqklessatavt.....kklpilqiHgeeDpvvplalgkaakevlkkllk.. 187
                    + g++ sriii GFSqG+ +a y +l+++ klggi ++s++lpl+++l+s   +        k+pi+  Hg+ D+v+++  g  +k +l + +   
     EFC37209.1 174 EfGVDPSRIIISGFSQGGSVAFYYGLSCKYKLGGIAILSSWLPLRTQLQSLLQNPEfdfknCKTPIFIAHGDADNVLEYKYGVSSKDYLVNQVLnq 269
                    846*******************************************99875443323333469************************998755435 PP

                    .....GEEEEEETT--SS--HHHHHHHHHHHHHH CS
  Abhydrolase_2 188 .....kvelksyeglaHsideeemqdikeflkkl 216
                         +ve+++y+g++Hs+ eee++d+  f+ k+
     EFC37209.1 270 gggseHVEFHTYKGMGHSSNEEELRDLGRFIGKV 303
                    6777889***********************9875 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.028        41       2      27 ..      80     105 ..      79     112 .. 0.83
   2 !   11.7   0.0   7.8e-05      0.12      51     117 ..     153     221 ..     146     228 .. 0.85
   3 !   16.2   0.0   3.1e-06    0.0047     186     234 ..     231     288 ..     219     292 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.028
  Hydrolase_4   2 epkavvvlvHGlaehsgryaelaeaL 27 
                  ++ a+++++HG+++ s+  +++++++
   EFC37209.1  80 SHNATMIFLHGFGDQSDGWSQTFDRF 105
                  57899***********9888877766 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 7.8e-05
  Hydrolase_4  51 hvpsfddyvdDlaafvekvkeehpel..plfllGhSmGGliallyllrypdkvaglilsaPalkikakl 117
                  +vps++ + + + +++++  +e +    ++++ G S GG +a+ y+l ++ k+ g+ + +++l ++++l
   EFC37209.1 153 DVPSMEACFEKITQLIDREINEFGVDpsRIIISGFSQGGSVAFYYGLSCKYKLGGIAILSSWLPLRTQL 221
                  578888888888899988888887776789************************999999998887764 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 3.1e-06
  Hydrolase_4 186 raakitlPllllhGeaDkvvdpeas.........relyerlgskdktlklypglyHel 234
                  + ++ ++P+++ hG+aD+v +++           + l +  gs+++++++y+g+ H+ 
   EFC37209.1 231 DFKNCKTPIFIAHGDADNVLEYKYGvsskdylvnQVLNQGGGSEHVEFHTYKGMGHSS 288
                  556788****************99999******77777888899************85 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.0   2.1e-07   0.00032       2      95 ..      86     212 ..      85     246 .. 0.60
   2 ?    0.8   0.0      0.42   6.2e+02     163     212 ..     229     291 ..     211     295 .. 0.54

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 2.1e-07
                    EEE--GC.....G.CHHHHHHHHCCT......CEEEEE--T......TSTS-GGCS--HHHC..............HHH....HHHHCCTT..... CS
  Abhydrolase_6   2 lllHGagssassW.lvapLaallaag......vhvlapDlp......GhGrsdpppldledl..............adl....aalldelaa.... 62 
                    ++lHG+g  +++W +   + ++l++       +  l+p +p      G+G s  +++++  l              +++     +l+d++++    
     EFC37209.1  86 IFLHGFGDQSDGWsQ--TFDRFLSDEkfkklkF--LVPNAPsqpislGFGMSFKSWYNVKSLavegpdvnedvpsmEACfekiTQLIDREINefgv 177
                    8************74..5555556666667677..9999994445555563333333333312223222211112222222223344444449999 PP

                    .TTSEEEEEETCHHHHHHHHHHCC.......EEEEES- CS
  Abhydrolase_6  63 gggpvvlvGHSlGGalalaaapla.....lvvgvlldp 95 
                    ++ ++++ G S+GG++a     +       + g+++ +
     EFC37209.1 178 DPSRIIISGFSQGGSVAFY---YGlsckyKLGGIAILS 212
                    99999***********999...4444476555544333 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.42
                    CCHHTT-TTGCEEECTT-C...............HHHHCHHCCCHSTTEEETCE...SSS-HHHH CS
  Abhydrolase_6 163 aaawadlpvpllvlggeDp...............lvprllerllaqagarlpvvlpgaGHlphle 212
                      +++ + +p+++ + +D+               lv + l + + ++++++ ++++g GH+ ++e
     EFC37209.1 229 EFDFKNCKTPIFI-AHGDAdnvleykygvsskdyLVNQVLNQGGGSEHVEF-HTYKGMGHSSNEE 291
                    4466666666655.4333333555555443333233333443333566666.99******98885 PP

>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   7.1e-07    0.0011      49     110 ..     157     218 ..     154     269 .. 0.75
   2 ?   -0.0   0.1      0.44   6.6e+02     195     208 ..     274     287 ..     266     289 .. 0.88

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 7.1e-07
                    HHHHHHHHHHHHHTHH.HHTETTCEEEEEEETHHHHHHHHHHHHHHHTT---EEEEEEESE-S CS
  Abhydrolase_3  49 vedalaalrwlaeqaw.elgadpsrivlaGdSaGGnlaaavalrardegepkvagqvliyPvt 110
                    +e +++ + +l +++  e+g+dpsri++ G S GG  a +  l ++ +   ++a +  + P+ 
     EFC37209.1 157 MEACFEKITQLIDREInEFGVDPSRIIISGFSQGGSVAFYYGLSCKYK-LGGIAILSSWLPLR 218
                    68899999999999999***********************99999997.56677777777733 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.44
                    --EEEEEETTEETT CS
  Abhydrolase_3 195 vevelieyegmvHg 208
                    ++ve++ y+gm H+
     EFC37209.1 274 EHVEFHTYKGMGHS 287
                    689**********6 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       1.9   2.9e+03     113     139 ..      26      53 ..      10      64 .. 0.50
   2 !    7.4   0.0    0.0018       2.7      43      77 ..     159     193 ..     156     197 .. 0.85
   3 !   11.1   0.0   0.00013       0.2     138     209 ..     233     304 ..     219     305 .] 0.81

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.9
                   H.HCCCC--TTTCHHHHHHHHHH-CGGG CS
  Peptidase_S9 113 e.eymewgnpeeneegykelspyspldn 139
                   + ey+e+ +  en    k++s +s++++
    EFC37209.1  26 WkEYQENLTFPENLSAEKKQSLLSKYQK 53 
                   2234444444455555555555555555 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0018
                   HHHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHH CS
  Peptidase_S9  43 nefdDfiaaaealakegyvdserlaitGgSyGGyl 77 
                   ++f+ + + ++  ++e+ vd++r++i G S GG +
    EFC37209.1 159 ACFEKITQLIDREINEFGVDPSRIIISGFSQGGSV 193
                   567777778888899999***************75 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 0.00013
                   GG-----EEEEEEETT-SSS-THHHHHHHHHHH......--S-S.EEEEEETTS-SSTTSSHHHHHHHHHHHHHHHHHC CS
  Peptidase_S9 138 dnvkaypplLlihGlaDdrvppaealklvaaLq......kkgkn.vlllifpdegHgvgkprakveelarllaFlkeal 209
                   +n   ++p+++ hG+aD+   ++ ++   + L         g + v+++++++ gH     +++ eel++l +F+ ++l
    EFC37209.1 233 KN--CKTPIFIAHGDADNVLEYKYGVSSKDYLVnqvlnqGGGSEhVEFHTYKGMGH-----SSNEEELRDLGRFIGKVL 304
                   45..799******************99999999888876566778***********.....445667777777766665 PP

>> FSH1  Serine hydrolase (FSH1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   2.5e-06    0.0037       4     191 ..      82     274 ..      79     286 .. 0.71

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 2.5e-06
        FSH1   4 kkkiLcLhGytqsgeiFraktsalrkllkklnvelvyldaplelaekadlpkseseeeekseeeeesraWfrkkde.......kneyegleesldavkd 95 
                 + ++++LhG++ +++ +++ + ++    k +++++  ++ap +     +l                +++W++ k         ++++ ++e +++++++
  EFC37209.1  82 NATMIFLHGFGDQSDGWSQTFDRFLSDEKFKKLKFLVPNAPSQP---ISL-----------GFGMSFKSWYNVKSLavegpdvNEDVPSMEACFEKITQ 166
                 56788999999999999999988866655567999999999887...333...........34566788888887788888889999999999999999 PP

        FSH1  96 yike......ngp.fdGiiGFSqGaalaallaslleellkeashpslkfailvsGfkleepkyeeyyeedki.....qtptLhvlGelDtvvdee.... 178
                  i++        p    i GFSqG+ +a ++    + +l         +ail s   l +++ +++ +++++     +tp++  +G++D+v + +    
  EFC37209.1 167 LIDReinefgVDPsRIIISGFSQGGSVAFYYGLSCKYKLG-------GIAILSSWLPL-RTQLQSLLQNPEFdfkncKTPIFIAHGDADNVLEYKygvs 257
                 9999444444223233467**********99888877665.......46776665555.5556665544444444449*************99776655 PP

        FSH1 179 rseaLaeafkns....s 191
                    +L++++ n+    +
  EFC37209.1 258 SKDYLVNQVLNQgggsE 274
                 66778887777755533 PP

>> Asp2  Accessory Sec system GspB-transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       1.5   2.3e+03      24     168 ..      27      38 ..       7      86 .. 0.49
   2 !   17.8   0.0   8.8e-07    0.0013     337     375 ..     162     200 ..     154     210 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.5
        Asp2  24 hfvelakleelkevleeeelkkkkkkfdvvlltsevsekelkellklieayqvlldeeleleeekqekllekklakqvdledkeellkkleakyfsgqy 122
                 +                                                                                                  
  EFC37209.1  27 K-------------------------------------------------------------------------------------------------- 27 
                 2.................................................................................................. PP

        Asp2 123 Geklkvsqvelskkfkgevqlegnlslklegdfgeefsqlltwksn 168
                                                    e+++ lt+ +n
  EFC37209.1  28 -----------------------------------EYQENLTFPEN 38 
                 ...................................22222222222 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 8.8e-07
        Asp2 337 ekiikiikekleeLgfeeeqlilsGlSMGtfgalyYgak 375
                 eki++ i+++++e+g + + +i+sG S G   a+yYg +
  EFC37209.1 162 EKITQLIDREINEFGVDPSRIIISGFSQGGSVAFYYGLS 200
                 689*********************************954 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   1.5e-06    0.0022      92     191 ..     175     290 ..     154     296 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.5e-06
         DLH  92 vpevstkkvgvvGfCmGGalalllaaev.pevdaavafYG.........lspekeleeaakikapilalfgeeDefipade....vekleealkaan.. 174
                 ++ v+++++ + Gf  GG +a+++      ++ + ++            + ++++  + ++ k+pi++ +g++D++ + +      + l +++ +++  
  EFC37209.1 175 FG-VDPSRIIISGFSQGGSVAFYYGLSCkYKLGGIAILSSwlplrtqlqSLLQNPEFDFKNCKTPIFIAHGDADNVLEYKYgvssKDYLVNQVLNQGgg 272
                 44.7789***************987766334555543333555**999999999*********************998765544444455554444323 PP

         DLH 175 .vdlelkvYpgagHaFan 191
                   ++e++ Y+g gH+ ++
  EFC37209.1 273 sEHVEFHTYKGMGHSSNE 290
                 267899999999998655 PP

>> Esterase_phd  Esterase PHB depolymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.0   5.7e-05     0.086      81     124 ..     164     207 ..     158     218 .. 0.82
   2 ?    1.5   0.0      0.12   1.7e+02     170     187 ..     237     254 ..     232     276 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.7e-05
  Esterase_phd  81 vvalvdalvdehrvdaarvyvaGlsaGaaladllalhypdvfaa 124
                   ++ l+d  ++e +vd++r+ ++G+s G+++a   +l    ++  
    EFC37209.1 164 ITQLIDREINEFGVDPSRIIISGFSQGGSVAFYYGLSCKYKLGG 207
                   778999999*********************98877766555555 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.12
  Esterase_phd 170 lpalvvqGdadtvvavkn 187
                    p ++ +Gdad+v++ k 
    EFC37209.1 237 TPIFIAHGDADNVLEYKY 254
                   5899*********98764 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.4   0.00032      0.47       3     106 ..      85     213 ..      83     230 .. 0.70
   2 ?    3.9   0.0     0.024        36     206     251 ..     223     287 ..     213     293 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00032
                    EEEE-STTTCGGGGTTGHHHHHHHHT....TSEEEEEE......ETTSTTSSSTTTGB..............CHH...SHHHHHHHHHHHHHHCTT CS
  Abhydrolase_1   3 lvilhGlpgssdvwaerglapaLakd....gfdvillD......lrGvgySspapacin.............ddy...gtasvaddldrildalgd 72 
                    +++lhG+++ sd w +   ++ +  d    +  +++++      ++G+g S +++  +              +     ++  +   +dr  + +g+
     EFC37209.1  85 MIFLHGFGDQSDGWSQ--TFDRFLSDekfkKLKFLVPNapsqpiSLGFGMSFKSWYNVKslavegpdvnedvP-SmeaCFEKITQLIDREINEFGV 177
                    7999999999999998..6666666668888888888833333345888888888766688888866554442.0444666666666666777777 PP

                    S..SEEEEEETHHHHHHHHHHHHHGGGEEEEEEESE CS
  Abhydrolase_1  73 d..kltlvGhSmGGmialayaaeyperVkalvllga 106
                    d  ++++ G+S+GG +a++y +  + +  +++ l++
     EFC37209.1 178 DpsRIIISGFSQGGSVAFYYGLSCKYKLGGIAILSS 213
                    63258899************8876666666666666 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.024
                    C........THHHHSEEEEEEETTCSSSCHHHHHHHHHC.....HTS......EEEEEEETCSSS CS
  Abhydrolase_1 206 e........lknvlaptlvisgtsDplvppkaledlaql.....lpk......krlvvisdagHl 251
                    +        +kn + p+++ +g+ D++  +k+++ +++      l++      ++ +++ + gH 
     EFC37209.1 223 SllqnpefdFKNCKTPIFIAHGDADNVLEYKYGVSSKDYlvnqvLNQgggsehVEFHTYKGMGHS 287
                    233355567799999***************99999998865555333444444555555555555 PP

>> AXE1  Acetyl xylan esterase (AXE1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   6.4e-05     0.095     155     189 ..     161     195 ..     151     204 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6.4e-05
                 HHHHHHHHHHHHTSTTEEEEEEEEEEETHHHHHHH CS
        AXE1 155 flDavrlveivaslpevDeeRvavlGasqGGalal 189
                 f  + +l++   +   vD++R+ + G sqGG++a 
  EFC37209.1 161 FEKITQLIDREINEFGVDPSRIIISGFSQGGSVAF 195
                 5566777777777788****************986 PP

>> DUF2974  Protein of unknown function (DUF2974)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00012      0.18      84     106 ..     173     202 ..     149     209 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00012
     DUF2974  84 g.......kiylgGhSkGGnlAvyaamnae 106
                 +       +i+++G+S+GG++A+y  + ++
  EFC37209.1 173 NefgvdpsRIIISGFSQGGSVAFYYGLSCK 202
                 334444447***************877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.62u 0.37s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 1800.75
//
Query:       EFC37210.1  [L=513]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.4e-97  325.0   0.3    5.5e-97  324.7   0.3    1.1  1  PhoPQ_related  PhoPQ-activated pathogenicity-related protein


Domain annotation for each model (and alignments):
>> PhoPQ_related  PhoPQ-activated pathogenicity-related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  324.7   0.3  3.1e-101   5.5e-97       2     366 .]      52     431 ..      51     431 .. 0.93

  Alignments for each domain:
  == domain 1  score: 324.7 bits;  conditional E-value: 3.1e-101
  PhoPQ_related   2 kdyvekedeelkyeltetkelegvtiyileltSQkWskeklvdps.lwkHkltivvPke.kkleetalllisggs......nenvkkkskeseset 89 
                     +yv++++++++y+l +t +++g+tiy+l++tS +W ++++v p+ +w H l+i++P++ +k+++++l +is+g         +  ++s+ + + +
     EFC37210.1  52 GNYVNQPESAYSYKLINTRSITGATIYTLNVTSLTWLPTSEVGPAnTWFHYLEITIPNNlNKNNRESLFFISNGDnnlavpGATDLTASPIHVPTF 147
                    68**************************************9998769************8899999*******99666665445556777788999 PP

  PhoPQ_related  90 laeiaretkavvaelsdvPnqpltfeddgk..arkEDdlvAytwrkfleeekdetl..plllpmtkaavraMdlvqeflkel.klkiekFvvsGaS 180
                    + + a +tk+v+a ++ vPnqp++++ d++  +r ED++++y w++fl+++++++l  + +lp++k    aMd+v +f+k++ +  iekF+vsGaS
     EFC37210.1 148 VYDTAVSTKSVTAIVYMVPNQPMSYNSDPThaTRVEDAIIGYGWNRFLQNTTKANLlyVTQLPQVKGSKMAMDTVVSFVKKQaNHVIEKFTVSGAS 243
                    9**************************98755799**************766666422689*******************998999********** PP

  PhoPQ_related 181 KRGWttwltaivDkrvkaivPvvidilnlekqlkhqlkaYGewslaledYvaegidellktpefkkLlkivDplsYlerltipkyiinasgDdffv 276
                    KRGWtt l ++ D+rv+ai+P+vi++  +++ + +++++  +w++a++dYv +g++++l +++f++L++ivDpl+Y +  +ipky i+a gD+ff+
     EFC37210.1 244 KRGWTTILLGAIDNRVAAIAPMVIPVYGTKEFIVRTYNNMCAWPWAFYDYVTNGVTDQLFDKSFESLTDIVDPLNYGRLKSIPKYQILALGDEFFA 339
                    ****************************************************************************7666**************** PP

  PhoPQ_related 277 pdstkfyfekLkgekalrivPnssHglsnkevveslvafvklvaagkelPeleweieese..gtiklkvksseapekvklwtatnesarDfR 366
                    pd  + +++k+kgek++r++Pn++H + n++v++ l +f+ + +++  +P+++++ e  +    i ++v+++ +p++vklw+atn+++rDfR
     EFC37210.1 340 PDLNNLFYSKIKGEKYVRYIPNTGHLMLNTNVLQVLGSFYASRLNNLVIPKYTFSHEFVNggVIIYVSVTNGIKPTAVKLWSATNPTSRDFR 431
                    ***************************************************99988877743567889999999*****************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (513 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.46
# Mc/sec: 3330.97
//
Query:       EFC37211.1  [L=552]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-06   26.8  40.8    2.2e-05   24.7  19.8    4.3  4  EamA      EamA-like transporter family
     0.0095   15.7   6.0       0.62    9.8   0.2    3.2  3  Connexin  Connexin
  ------ inclusion threshold ------
        0.6   10.1   6.2        3.8    7.5   4.0    3.0  2  DUF1077   Protein of unknown function (DUF1077)
        1.2    9.3   4.9        3.5    7.7   0.3    2.8  3  SRA       SET and RING associated domain


Domain annotation for each model (and alignments):
>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.1    0.0014       6.2       1      55 [.     123     188 ..     123     197 .. 0.69
   2 !    5.2   4.4    0.0049        22      61     116 ..     224     279 ..     211     283 .. 0.83
   3 ?    1.8   0.2     0.055   2.5e+02     114     136 ..     339     361 ..     326     363 .. 0.83
   4 !   24.7  19.8   4.8e-09   2.2e-05       3     135 ..     345     492 ..     343     494 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0014
        EamA   1 llgillallaalfwaiyfvlskillrkvspl....tltfvrfliagill........liiallkegk 55 
                 +lg+l ++++  +++i +++s++l ++  p     +l++ ++ +a+ill        li++l +++k
  EFC37211.1 123 MLGWLACIAVHTLFGIHPIFSRYLQSTS-PNkfppMLLVTSCHVAAILLysprivylLIVYLRNKWK 188
                 579********************84444.22234466667888999999766655544444444444 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0049
        EamA  61 lkdwllllllgllgtvlafllffyalkktsasnaslitslePvftlilsvlllgek 116
                 +  ++l ++  +++ vl  +  + + k+tsa ++ l+ +++P + ++l v++++  
  EFC37211.1 224 RIKFFLPIISFFVSLVLRSFTNVVSSKYTSALFVQLFALTTPFILAFLTVFVYNRW 279
                 4455666888889999999999*****************************99865 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.055
        EamA 114 gekltlkqllgivlillGvllil 136
                  e++tl++llgi+ ++++ + ++
  EFC37211.1 339 SENITLWDLLGIASSIISSVCLV 361
                 699***********999988776 PP

  == domain 4  score: 24.7 bits;  conditional E-value: 4.8e-09
        EamA   3 gillallaalfwaiyfvlskillrkv.......spltltf......vrfliagillliiallkegkl.aklslkdwllllllgllgtvlafllffyalk 87 
                 ++ll +++++++++  v     lr++       + +++t+        f++a  ++++ + + +++l  +l+ kdw+ ++ + ++  ++a+ l + a++
  EFC37211.1 345 WDLLGIASSIISSVCLVWYMLSLRYMkqeesqgNAVSVTGeslfilQLFILALTFVVPSLIVDDWTLwTRLNTKDWIMFFGFTIFVYMMANHLNIFAIS 443
                 667777777777777777777777777777777555555543333234456666667778888888899****************************** PP

        EamA  88 ktsasnaslitslePvftlilsvlllgeklt.lkqllgivlillGvlli 135
                  +++++++ +++l  + t+++s+l+l+e+l+ ++qllg++++l++v + 
  EFC37211.1 444 MLGSTRVGSMLALRLISTIFFSILILQESLKsIWQLLGCIIVLASVSYF 492
                 ******************************63689*******9999765 PP

>> Connexin  Connexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.27   1.2e+03      95     123 ..      70     100 ..      25     140 .. 0.57
   2 !    9.8   0.2   0.00014      0.62      65     126 ..     152     213 ..     147     277 .. 0.62
   3 !    7.3   0.3   0.00081       3.6      75     141 ..     476     539 ..     468     551 .. 0.50

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.27
    Connexin  95 lhkiakeekekek..eeeekeeeekeeekkk 123
                 +++i+++++++++  ++e+ +++ kee++++
  EFC37211.1  70 IYEINQQHDDDNEeiDQEPIITSGKEEKNQS 100
                 2222222221111112222222222222222 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00014
    Connexin  65 daffpishvrfwvlqiilvstPsllylvyvlhkiakeekekekeeeekeeeekeeekkkkke 126
                 ++f p+  v   ++  il+  P ++yl++v  + + +++++ ke++e++ +++ee++++  +
  EFC37211.1 152 NKFPPMLLVTSCHVAAILLYSPRIVYLLIVYLRNKWKNRKEIKEMKERTMNDDEEQQQQVVS 213
                 677777777778888999*********99999888888866654444444444444433111 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.00081
    Connexin  75 fwvlqiilvstPsllylvyvlhkiakeekekekeeeekeeeekeeekkkkkekkkkkkkeeekekkk 141
                  w l   ++ + s+ y++y+  +++k++ + + + +++e+ee+++++++  ++ +  ++++++++++
  EFC37211.1 476 IWQLLGCIIVLASVSYFMYSESQQEKKSATVQ-QPSPQEDEEEHNSTEM--DTVELITRDSNENSQS 539
                 57777777888888888888777777766444.2333333333333333..2222222222222222 PP

>> DUF1077  Protein of unknown function (DUF1077)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.12   5.2e+02      46      94 ..     123     170 ..     118     182 .. 0.83
   2 ?    7.5   4.0   0.00085       3.8      29      70 ..     427     468 ..     416     497 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.12
     DUF1077  46 mvlmllvnpikallsvnkaFkkleseksksklllqklvyvllqllllal 94 
                 m++ l   ++++l+ ++  F+++ +++s  + + ++l+   +++++++l
  EFC37211.1 123 MLGWLACIAVHTLFGIHPIFSRYLQSTS-PNKFPPMLLVTSCHVAAILL 170
                 5666777789999*********999977.78888999888888888776 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.00085
     DUF1077  29 lfmlYmsGnslqifsimmvlmllvnpikallsvnkaFkkles 70 
                  +++Ym+ n+l+if i m++ + v  + al  +++ F ++  
  EFC37211.1 427 TIFVYMMANHLNIFAISMLGSTRVGSMLALRLISTIFFSILI 468
                 4789****************9999999999888888866654 PP

>> SRA  SET and RING associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.3   0.00078       3.5      41      86 ..      39      86 ..      15      98 .. 0.74
   2 ?    2.8   0.0     0.027   1.2e+02      49     103 ..     171     223 ..     130     229 .. 0.60
   3 ?   -3.2   0.2       1.8   8.2e+03      52      83 ..     510     541 ..     493     548 .. 0.53

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00078
                S..S-TTEEEE---SSB-SSEEEEE-TTSSEEEEEESSHHHHHHHHHH CS
         SRA 41 p..leekeqvWfPklyenkewlNelsedgtviyeynedetekdekled 86
                p   ++++q   P l  ++  +N+ se + +iye n++ ++++e++++
  EFC37211.1 39 PdnDSSSQQFKLPSLSSSQLLNNSSSESEHIIYEINQQHDDDNEEIDQ 86
                2557788999***************************55555444443 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.027
                 E---S......SB-SSEEEEE-TTSSEEEEEESSHHHHHHHHHHHHH.S-SEEEEEEEEE- CS
         SRA  49 WfPkl......yenkewlNelsedgtviyeynedetekdekledklleknekrivFakvkd 103
                   P++      y +++w N+  + ++++ e++++++e+++++        ++ + F ++k+
  EFC37211.1 171 YSPRIvyllivYLRNKWKNR--KEIKEMKERTMNDDEEQQQQV------VSNTALFERIKK 223
                 44555555555888888885..556666666663333333222......233444444444 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 1.8
                 -SSB-SSEEEEE-TTSSEEEEEESSHHHHHHH CS
         SRA  52 klyenkewlNelsedgtviyeynedetekdek 83 
                   +e +e +N+   d  ++++++ +e+ ++ +
  EFC37211.1 510 SPQEDEEEHNSTEMDTVELITRDSNENSQSGQ 541
                 44455555565555555555554444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (552 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2052  (0.114451); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.80u 0.33s 00:00:01.13 Elapsed: 00:00:00.51
# Mc/sec: 3243.87
//
Query:       EFC37212.1  [L=150]
Description: cofilin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.1e-23   82.4   0.7    2.4e-23   82.2   0.7    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
     0.0092   16.0   0.6      0.012   15.6   0.6    1.2  1  SelP_C       Selenoprotein P, C terminal region


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.2   0.7   2.6e-27   2.4e-23       2     121 .]      12     144 ..      11     144 .. 0.94

  Alignments for each domain:
  == domain 1  score: 82.2 bits;  conditional E-value: 2.6e-27
                  HHHHHHHCTTT.....SSEEEEEEECTTTEEEEEESS-...HHHHHHHHHHTTT-EEEEEEEEEECCS........ECCEEEEEEEEE--TTS-HHHH CS
  Cofilin_ADF   2 keafkelksgk....ktkyilfkidddkeeivveeege...tyeelreelpeseprYavydveyehdd........eskrsklvfIswvPdsapikqk 84 
                  +++++e+++gk    ++k++++k+++   +i++++e +   +++el+++lp ++ r+++y++++e ++        e++r+k++f++w+P+++++k+k
   EFC37212.1  12 IKTYEEMRMGKgsnkDKKFLVLKMQES--SIQIDQELSqlsSLDELTANLPPKNSRFVCYHLSFEMPSqnetcqirEGTRTKMMFLTWCPNETNVKEK 107
                  689**********9999*******976..69999966677899***********************999999****9**************99***** PP

                  HHHHHHHHHHHHHCTTSEEEEEE-CGGCCSHHHHHHH CS
  Cofilin_ADF  85 mlyasskdalkkelkgisveieatdldelteeelkek 121
                    +a++ +++k++l+g+s +i++++++e++e+++ ek
   EFC37212.1 108 FQVAATVKTVKQKLNGLSATIHCSTKSEIDEKSMIEK 144
                  ********************************99886 PP

>> SelP_C  Selenoprotein P, C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.6   1.3e-06     0.012      32     124 ..      40     135 ..      12     146 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.3e-06
      SelP_C  32 rcinqllcklskdseaa....lssccchcrhlifektgsaitcqcaenlpslc.scqgllaeekviescqcrlppaacqisqqlnpteasakcscknk 124
                   i+q l +ls   e++    ++     c hl fe      tcq +e   +          e +v e  q+     ++  +q+ln + a+ +cs k +
  EFC37212.1  40 IQIDQELSQLSSLDELTanlpPKNSRFVCYHLSFEMPSQNETCQIREGTRTKMmFLTWCPNETNVKEKFQVAATVKTV--KQKLNGLSATIHCSTKSE 135
                 4577888888765554312226788889******************987654404455567899***99987665554..6************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       872  (0.0486363); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 952.19
//
Query:       EFC37213.1  [L=1170]
Description: rhoGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.7e-16   59.0  10.5    6.7e-16   59.0  10.5    2.6  2  RhoGEF    RhoGEF domain
  ------ inclusion threshold ------
      0.031   14.8   0.3      0.031   14.8   0.3    3.3  3  PH        PH domain


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.0  10.5   7.5e-20   6.7e-16       2     180 ..     164     359 ..     163     361 .. 0.91
   2 ?   -0.8   0.4      0.17   1.6e+03      32      52 ..     389     409 ..     357     499 .. 0.59

  Alignments for each domain:
  == domain 1  score: 59.0 bits;  conditional E-value: 7.5e-20
                 HHHHHHHHHHHHHHHHHHHHHTHCCCHHCTCCHHHHHHHHC..TTHHHHHHHHHHHHHHHHHHHH.........HHHTTSS-S-SHHHHHHHHSTHHHH CS
      RhoGEF   2 ikElleTErsYvrdLkvlvevylkplselevlseeeikiiF..snieeilelhrsflleeLeerl........keseeqkeaqsigdvflkfadkfkkY 90 
                 +k l++ E++Y+ +L +l e+++ +l+++ ++++ee++ +F  s+++ i++++ s+ll+++e+ +        +++  + +a++ig++f+++++ +k+Y
  EFC37213.1 164 LKRLIKHEANYLFELDLLREKFIGTLKRSDLINSEEMERLFcySQLNIIWNVN-SELLNQFETFYttlehineQSTVVSPRASTIGQIFMRLTPFLKNY 261
                 67799**********************************99999*********.99999999988777766542566778899**************** PP

                 HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHTSGGG..........TT--HHHHTTHHHHHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHH CS
      RhoGEF  91 seYcsnypnalkllkelskknkkfkafleeaeerpec..........skldLeslLikPvqRlprYpLLLkellkntpeshpdyealkkaleaikevas 179
                  +Y ++ + ++  +++++ k+++fk++++++e+  +c          s+++L + + +P q +++Y   L +ll   ++s ++ + l+++l+ i+ v++
  EFC37213.1 262 IQYSNQLDTCIVAINNKRLKDSYFKSIVKKLER--MCtklasaerkdSSFTLLQAMKTPLQQFVHYRKALIDLLAISQSSTDECNILNDSLKLIEVVNQ 358
                 ******************9***********774..556689999999******************************9999999**********99987 PP

                 H CS
      RhoGEF 180 e 180
                 +
  EFC37213.1 359 T 359
                 6 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.17
                 CCHHHHHHHHCTTHHHHHHHH CS
      RhoGEF  32 vlseeeikiiFsnieeilelh 52 
                 v++  + + +F+n  e++  +
  EFC37213.1 389 VVTIIKPNRVFINEAEVYMTS 409
                 222222233444444444444 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.2       0.2   1.8e+03      24      89 ..     399     467 ..     370     471 .. 0.53
   2 ?   14.8   0.3   3.5e-06     0.031      62     104 ..     541     579 ..     523     580 .. 0.73
   3 ?   -1.0   0.0      0.29   2.6e+03      39      93 ..    1050    1099 ..    1033    1101 .. 0.62

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.2
                 EEETTEEEEESST......TCTTESSEEEEEESTTEEEEEEECTT.SSSSTSEEEEEESTSSSTEEEEEEESS CS
          PH  24 vLkdsellyyknd......ksekdkepkgsislsncevvevvate.dpkrkfcfelriverngsrtyllqass 89 
                 ++++ e+++ +++      +++++k++ +  + ++++  ++++++  +++k+++++ ++   + +++++++s+
  EFC37213.1 399 FINEAEVYMTSSEnnyleiRKKRKKKKDNNANAISVTKLDIPNENfFKDEKNKLVV-FH--FN-DSIVICTST 467
                 44445555555556677443333444444444444444444433324444444444.22..23.667777665 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 3.5e-06
                 TSSSSTSEEEEEESTSSSTEEEEEEESSHHHHHHHHHHHHHHH CS
          PH  62 edpkrkfcfelriverngsrtyllqasseeerkeWikaiqsai 104
                 ++++  f+f+l++     sr y++++ +e+ +++W++aiq+++
  EFC37213.1 541 SNSDLSFMFQLITW----SRIYTFKFMDESTKTQWMYAIQQSL 579
                 24455555555444....69********************976 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.29
                  TTESSEEEEEESTTEEEEEEECTTSSSSTSEEEEEESTSSSTEEEEEEESSHHHH CS
          PH   39 ekdkepkgsislsncevvevvatedpkrkfcfelriverngsrtyllqasseeer 93  
                  +++++p++si   +   ++    e++  +++ el  + +n   ++ + + ++ee+
  EFC37213.1 1050 PPSSTPRRSIVALDSPRKK----EEEIAPWQKELLNKYKND-GKFKFVTQTAEEK 1099
                  3566666666666665554....466666666665555554.6777777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1561  (0.0870656); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.88u 0.32s 00:00:01.20 Elapsed: 00:00:00.49
# Mc/sec: 7228.31
//
Query:       EFC37214.1  [L=163]
Description: histone H2B [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      4e-19   69.3   4.3      4e-19   69.3   4.3    2.0  2  Histone         Core histone H2A/H2B/H3/H4
    9.1e-07   29.1   0.1    2.9e-06   27.5   0.1    1.8  1  CBFD_NFYB_HMF   Histone-like transcription factor (CBF/NF-Y) 
     0.0034   17.4   0.1     0.0054   16.8   0.1    1.3  1  GMP_synt_C      GMP synthase C terminal domain
  ------ inclusion threshold ------
          2    8.4   5.6       0.42   10.6   0.6    2.2  2  DUF3915         Protein of unknown function (DUF3915)
          9    6.0  10.0       0.47   10.1   1.7    2.2  2  FAM176          FAM176 family


Domain annotation for each model (and alignments):
>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.3   4.3   1.1e-22     4e-19      19     130 ..       6     114 ..       1     115 [. 0.83
   2 ?    1.2   4.1      0.12   4.4e+02      38      59 ..     134     155 ..     118     163 .] 0.36

  Alignments for each domain:
  == domain 1  score: 69.3 bits;  conditional E-value: 1.1e-22
                 XXXXXXXHT.TS-SSSSB--TTT-XTTHHHHHHHHHHHHXXSXXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTX CS
     Histone  19 kkvsakker.kasskskkkkkrryrpgtvalkeirkyqkstdlliqklpfaRvvreivksekedlrisaeavlalqealEallvelfeeAnllakhaKR 116
                 kk +++k++ k+ +k k +kk++ + g  ++ e++ + k++++++++ ++++v+r++++    d++is +a+ ++++++ +++++++ eA+ l++ +  
  EFC37214.1   6 KKSTESKDKtKETKKDKVTKKTTKASGDGEEGEKDDKKKKSRHESYSSYIYKVLRQVHS----DIGISTKAMSIMNSFIQDIFERIANEAAQLCRVNGT 100
                 333333333455556666666677777777888888889999*****************....************************************ PP

                 SEEXHHHHHHHHHH CS
     Histone 117 vTitpkDiqlArrl 130
                 +T+ +++iq+A+rl
  EFC37214.1 101 KTLSSREIQTAVRL 114
                 *************7 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.12
                 TTT-XTTHHHHHHHHHHHHXXS CS
     Histone  38 krryrpgtvalkeirkyqkstd 59 
                 k+++  g+ a k+++k++k+++
  EFC37214.1 134 KYQTSSGKTAPKKREKKEKKEK 155
                 2222222222222222222221 PP

>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.1   8.1e-10   2.9e-06       8      65 .]      55     112 ..      53     112 .. 0.95

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 8.1e-10
                    HHHHHHCC.TTXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF   8 vkkImksd.pdarkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65 
                    + k++++   d++ i+  A  +++ +++   e++a+eAa++c  ++ Kt++   i+ Av
     EFC37214.1  55 IYKVLRQVhSDIG-ISTKAMSIMNSFIQDIFERIANEAAQLCRVNGTKTLSSREIQTAV 112
                    7799****77777.******************************************998 PP

>> GMP_synt_C  GMP synthase C terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   1.5e-06    0.0054      39      78 ..      58      97 ..      45     111 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.5e-06
                EEEEE---------B----HHHHHHHHHHHHHHSTT---E CS
  GMP_synt_C 39 alRaveseDamtadvaelpyevLekissrivnevkgvnrv 78
                +lR v+s+ +++++++++  +++++i +ri ne  +++rv
  EFC37214.1 58 VLRQVHSDIGISTKAMSIMNSFIQDIFERIANEAAQLCRV 97
                79*************************************9 PP

>> DUF3915  Protein of unknown function (DUF3915)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.6   0.00012      0.42      27      90 ..      35      98 ..       5     111 .. 0.72
   2 ?   -0.2   0.5      0.27   9.5e+02      23      34 ..     146     156 ..     132     163 .] 0.47

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00012
     DUF3915 27 ererederekerekkkerhavcnvlasiavgtelsllsikgnvtfrnvifegfangvalfsaln 90
                e  ++d+++k+   +     + +vl+++     +s  ++    +f + ife +an  a +  +n
  EFC37214.1 35 EEGEKDDKKKKSRHESYSSYIYKVLRQVHSDIGISTKAMSIMNSFIQDIFERIANEAAQLCRVN 98
                33333444444445566678999****99999999999999999***********999888776 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.27
     DUF3915  23 drererereder 34 
                 +re++ e++++ 
  EFC37214.1 146 KREKK-EKKEKS 156
                 22221.122222 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   1.7   0.00013      0.47      52      91 ..      14      53 ..       3     105 .. 0.63
   2 ?    0.9   1.4     0.091   3.3e+02      54      69 ..     142     157 ..     119     163 .] 0.44

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00013
      FAM176 52 erlkkkkkklkeesekasededeeeeeeeedsseseaeee 91
                +++++kk+k +++++kas d +e e+++++++s++e+ ++
  EFC37214.1 14 KTKETKKDKVTKKTTKASGDGEEGEKDDKKKKSRHESYSS 53
                2344445555555556677766655555555544443332 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.091
      FAM176  54 lkkkkkklkeesekas 69 
                 +++kk+++ke++ek++
  EFC37214.1 142 TAPKKREKKEKKEKSE 157
                 2222222222222111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2536  (0.141447); expected 358.6 (0.02)
Passed bias filter:                      639  (0.0356406); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.47
# Mc/sec: 1039.13
//
Query:       EFC37215.1  [L=1008]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-34  118.9   0.0    1.2e-32  113.4   0.0    2.6  1  DAP3      Mitochondrial ribosomal death-associated protein 3


Domain annotation for each model (and alignments):
>> DAP3  Mitochondrial ribosomal death-associated protein 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.4   0.0   6.7e-37   1.2e-32       1     311 [.     714    1003 ..     714    1004 .. 0.83

  Alignments for each domain:
  == domain 1  score: 113.4 bits;  conditional E-value: 6.7e-37
                  ----SHHHHHHHHHTTS-SSS---E....EEEE-SSSSSTTTTHHHHHHHGGGS--EEEEES-GGGGTSS-S--EEESTTSSEEE-HHHHHHHHHHH CS
        DAP3    1 llvReetlelikklkkadkkkkvkr....lvltGekgsGKSvlLlqalayAlekgwvvlhvpeaedlvngtteyapseseeklyvQpeataalLsri 93  
                  llvRe+ l +++++++ +k+kk+      ++l G +gsGKS  L+  +  A+++g++v+h+p+a  +++g   + ps+  ++ ++ p+ t  +L+++
  EFC37215.1  714 LLVREPVLPIVNEIQSLSKNKKKLTtdpgYLLMGIQGSGKSACLATCVFNAYTNGVLVVHIPSAYHWTQGIHFVEPSPVLQGYFDAPLPTRDFLKAF 810 
                  69********88888874444433223349******************************************************************* PP

                  TTSSHHHHTT-EE-S-EE-SSS-EE-SSEEHHHHHHHHHH-SSSHHHHHHHHHHHHHHHTTSS--EEEEEE-GGGGSS-BS--........-TTS-- CS
        DAP3   94 lkaNeevLkklklskeyellkresvkagstLleLvklgikdaksawdvfqallkeLkaqskgrvpvlvtvDglnallkntkyk........sadkkp 182 
                  ++aN e+Lk +kls+ey l  ++  k  +tL+eL++    ++ + + vf+++l+eL + ++   p+l+++D++n l + t y+        ++  + 
  EFC37215.1  811 MTANTEILKGMKLSREYTLPLESGQKVPTTLYELCDYALLSDGNISVVFKFVLDELINDKT--TPMLFAIDDYNFLHDYTCYQygnlddftTTVPQK 905 
                  ********************99999999********98877766666**************..*************999877522111111444567 PP

                  B-GGGBHHHHTTHHH..HS--SSS-EEEEE---SS-SS--SS---HHHHHTTTTTGGG-S-E................EEE--.---GGGTHHHHHH CS
        DAP3  183 ihahdLtlvkhfldllsgksklknggvvvaLaatsssntpksatlevallqeearpqldpYvkkydkrvaealkgkvepieve.glskeEarslley 278 
                  +ha++ tlv+ +  +   +++ +n+ +v   a t +++tp+    +v+l +e+    ld                   p+ v+  +s  E+++++ey
  EFC37215.1  906 VHAKNYTLVRALSRI--IQQNAPNKLIV--AANTNKNKTPN----KVYLMEENV---LD-------------------PVYVSsRYSYPELENIVEY 972 
                  888888888888888..66777888776..66666666666....566655555...44...................5556659************ PP

                  HHHTT---STTSSHHHHHHHHHTTSS-HHHHHH CS
        DAP3  279 yadsgvlqekvneelveeklslsgngnprelek 311 
                  y++s  +    n+e ++e l ++++g+p+  +k
  EFC37215.1  973 YQSSAFVF--GNKENFMEDLLFMSGGVPQRVFK 1003
                  ********..799***************98766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1008 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1451  (0.0809303); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.86u 0.30s 00:00:01.15 Elapsed: 00:00:00.48
# Mc/sec: 6277.87
//
Query:       EFC37216.1  [L=116]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.2e-11   42.3   0.0      2e-07   31.5   0.0    2.1  1  Ank_2     Ankyrin repeats (3 copies)
    9.1e-08   31.8   0.0    2.3e-05   24.4   0.0    3.1  3  Ank_3     Ankyrin repeat
    6.6e-07   29.5   0.0    6.8e-05   23.1   0.0    2.9  3  Ank       Ankyrin repeat
    9.9e-07   29.2   0.0     0.0022   18.5   0.0    2.5  3  Ank_4     Ankyrin repeats (many copies)
    0.00031   21.0   0.0      0.046   14.0   0.0    2.5  2  Ank_5     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
       0.15   11.0   0.0       0.22   10.5   0.0    1.3  1  Rif1_N    Rap1-interacting factor 1 N terminal


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.5   0.0   6.9e-11     2e-07      37      83 .]      21      72 ..      10      72 .. 0.81

  Alignments for each domain:
  == domain 1  score: 31.5 bits;  conditional E-value: 6.9e-11
       Ank_2 37 gnleivklLleh.ad....ndgrtpLhyAarsghleivklLlekgadinlkd 83
                + +e+v+++le+ a+     +g ++L++A++sg++++v++L+++ga++++k+
  EFC37216.1 21 DRVETVRTMLENgANpeseFNGSSALMVACFSGNSKVVRMLIQCGASLDRKN 72
                34599*****98844444477*********************99***99886 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0      0.16   4.7e+02      14      29 ..      22      36 ..      15      38 .. 0.78
   2 !   24.4   0.0   7.6e-09   2.3e-05       1      30 [.      41      69 ..      41      70 .. 0.94
   3 ?    1.6   0.0      0.21   6.2e+02       1      19 [.      88     106 ..      88     112 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.16
       Ank_3 14 nleivkfLlenkgadv 29
                ++e v+ +le +ga++
  EFC37216.1 22 RVETVRTMLE-NGANP 36
                456799****.8*997 PP

  == domain 2  score: 24.4 bits;  conditional E-value: 7.6e-09
       Ank_3  1 nGetpLhlAarsgnleivkfLlenkgadvn 30
                nG ++L++A+ sgn ++v++L++ +ga ++
  EFC37216.1 41 NGSSALMVACFSGNSKVVRMLIQ-CGASLD 69
                799********************.**9876 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.21
       Ank_3   1 nGetpLhlAarsgnleivk 19 
                 +G tp  +A + +++e ++
  EFC37216.1  88 DGLTPYQIASKLNHVECAR 106
                 699*******999998555 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.29   8.7e+02      16      27 ..      24      36 ..      15      39 .. 0.79
   2 !   23.1   0.0   2.3e-08   6.8e-05       1      31 [.      41      72 ..      41      73 .. 0.92
   3 ?    1.9   0.0      0.12   3.7e+02       1      19 [.      88     106 ..      88     110 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.29
                HHHHHHH.TTTST CS
         Ank 16 riiklLL.hGAnl 27
                + ++  L +GAn+
  EFC37216.1 24 ETVRTMLeNGANP 36
                678889989***8 PP

  == domain 2  score: 23.1 bits;  conditional E-value: 2.3e-08
                TSBBHHHHHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank  1 dGnTPLHlAatngkkriiklLL.hGAnlnald 31
                +G ++L++A+  g+  ++++L+ +GA+l+ ++
  EFC37216.1 41 NGSSALMVACFSGNSKVVRMLIqCGASLDRKN 72
                799*******999999******99****9876 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.12
                 TSBBHHHHHHHHTTHHHHH CS
         Ank   1 dGnTPLHlAatngkkriik 19 
                 dG TP  +A+  +++++++
  EFC37216.1  88 DGLTPYQIASKLNHVECAR 106
                 899**99*99999977764 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   7.4e-07    0.0022      12      55 .]      21      62 ..      11      62 .. 0.84
   2 !   14.7   0.0   1.2e-05     0.035       2      51 ..      43     105 ..      42     108 .. 0.64
   3 ?    3.8   0.0     0.031        93       2      23 ..      90     111 ..      89     116 .] 0.78

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 7.4e-07
       Ank_4 12 grlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklLl 55
                 r+e+vr  le+ga++      +G +al  A+  gn +++++L+
  EFC37216.1 21 DRVETVRTMLENGANPES--EFNGSSALMVACFSGNSKVVRMLI 62
                799************433..234889*****************8 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.2e-05
       Ank_4   2 ltaLhyaaisgrlelvrlLlekgad.............inaqdnrsGetalhiAakrgnveil 51 
                 ++aL  a+ sg+ ++vr L++ ga+             + a  n +G+t+ +iA k ++ve++
  EFC37216.1  43 SSALMVACFSGNSKVVRMLIQCGASldrknqedegvvfVAAKNNQDGLTPYQIASKLNHVECA 105
                 579999**************8788822333344444444443233366666666666666665 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.031
       Ank_4   2 ltaLhyaaisgrlelvrlLlek 23 
                 lt++  a + +++e++r + ++
  EFC37216.1  90 LTPYQIASKLNHVECARTISDY 111
                 7888899999999999988765 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.0   1.6e-05     0.046       1      44 [.      29      72 ..      29      78 .. 0.77
   2 ?    4.5   0.0     0.015        45      13      32 ..      86     105 ..      80     111 .. 0.62

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.6e-05
       Ank_5  1 LlehgpadvnrldgggntpLhvAakygaadvvrlLl..argadlnl 44
                +le+g a++   + +g ++L+vA+  g++ vvr+L+     +d++ 
  EFC37216.1 29 MLENG-ANPES-EFNGSSALMVACFSGNSKVVRMLIqcGASLDRKN 72
                68888.88866.57888*******************5544444444 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.015
       Ank_5  13 dgggntpLhvAakygaadvv 32 
                 +++g tp  +A+k ++ +++
  EFC37216.1  86 NQDGLTPYQIASKLNHVECA 105
                 44455555566666666655 PP

>> Rif1_N  Rap1-interacting factor 1 N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   7.4e-05      0.22     109     149 ..       2      45 ..       1      52 [. 0.86

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 7.4e-05
                 HHHHHHHHH--THHHHS-HHHHHHHHTTCCS--....----HHH CS
      Rif1_N 109 thllsvlsqQkFsskimtservkrllsalenie...ervkgksi 149
                 ++++s++s+++F  + + ++rv+++ ++len     ++++g s 
  EFC37216.1   2 NQHMSFISEEEFVFSCLDTDRVETVRTMLENGAnpeSEFNGSSA 45 
                 89****************************98766677777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       492  (0.0274416); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 781.50
//
Query:       EFC37217.1  [L=1106]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.2e-14   53.5   0.1        0.4   10.8   0.0    9.0 10  NHL           NHL repeat
    2.6e-06   27.2   1.3      0.082   12.5   0.1    5.8  5  SGL           SMP-30/Gluconolactonase/LRE-like region
    0.00034   20.7   0.2        3.2    7.6   0.0    3.4  3  Phytase-like  Esterase-like activity of phytase
  ------ inclusion threshold ------
       0.17   11.5   0.0       0.32   10.5   0.0    1.4  1  CD34_antigen  CD34/Podocalyxin family


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.42   1.9e+03      15      21 ..     232     238 ..     231     240 .. 0.86
   2 ?   -0.3   0.0      0.29   1.3e+03       3      16 ..     275     288 ..     273     288 .. 0.89
   3 !    5.8   0.0    0.0034        15       1      27 [.     481     508 ..     481     509 .. 0.94
   4 !    9.8   0.0   0.00019      0.86       4      27 ..     582     605 ..     581     606 .. 0.94
   5 !    7.3   0.0    0.0011       5.1       3      27 ..     638     662 ..     637     663 .. 0.93
   6 ?    1.0   0.0      0.12   5.3e+02       3      18 ..     677     692 ..     676     692 .. 0.90
   7 !   10.8   0.0   8.9e-05       0.4       2      27 ..     780     805 ..     779     806 .. 0.88
   8 ?   -1.4   0.0      0.65   2.9e+03       1      15 [.     834     848 ..     834     851 .. 0.89
   9 ?    4.2   0.0     0.011        50       1      17 [.     890     906 ..     890     906 .. 0.90
  10 ?   -1.1   0.0      0.55   2.5e+03       8      27 ..     957     977 ..     955     978 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.42
                 EEEEECC CS
         NHL  15 iyVaDse 21 
                 +yVaDs+
  EFC37217.1 232 LYVADSN 238
                 7****98 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.29
                 SEEEEEEETTTEEE CS
         NHL   3 yPhGvavdsnGdiy 16 
                 yP+ + v+s+G+i+
  EFC37217.1 275 YPTKIFVNSGGEIL 288
                 89**********96 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0034
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P+Gv ++ + G  ++aDs+n rv+v
  EFC37217.1 481 LNEPSGVFYSkTLGKTFIADSKNDRVRV 508
                 799***********************98 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00019
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P+++ v+  Gdiy aD  nhr+++
  EFC37217.1 582 PESIYVTEEGDIYFADISNHRIRK 605
                 99********************97 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.0011
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                 +P+Gv ++  G++y  +se+h +++
  EFC37217.1 638 SPSGVYLNRKGEVYFVESESHKIRK 662
                 6********************9986 PP

  == domain 6  score: 1.0 bits;  conditional E-value: 0.12
                 SEEEEEEETTTEEEEE CS
         NHL   3 yPhGvavdsnGdiyVa 18 
                 +Ph + v+sn++++V+
  EFC37217.1 677 SPHRLIVTSNDEVIVS 692
                 79999*********95 PP

  == domain 7  score: 10.8 bits;  conditional E-value: 8.9e-05
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                  + ++v+v++++++++aDs  h++++
  EFC37217.1 780 MDISSVVVSPDNELFIADSMDHTIRK 805
                 56689**************9999985 PP

  == domain 8  score: -1.4 bits;  conditional E-value: 0.65
                 BSSEEEEEEETTTEE CS
         NHL   1 fnyPhGvavdsnGdi 15 
                 +n P++++  +nGd+
  EFC37217.1 834 LNGPTSLSSAKNGDL 848
                 799*******99998 PP

  == domain 9  score: 4.2 bits;  conditional E-value: 0.011
                 BSSEEEEEEETTTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyV 17 
                 +++P+++av+++Gd +V
  EFC37217.1 890 LSMPQSLAVSPGGDALV 906
                 689**********9877 PP

  == domain 10  score: -1.1 bits;  conditional E-value: 0.55
                 EEE.TTTEEEEEECCCTEEEE CS
         NHL   8 avd.snGdiyVaDsenhrvqv 27 
                 a + ++  +y  Ds n+ +++
  EFC37217.1 957 AFSnDGLSVYFVDSSNNLIRK 977
                 666688888889*99999986 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.11   4.8e+02      70     124 ..     130     179 ..      96     313 .. 0.62
   2 ?   -3.3   0.0       1.2   5.4e+03     194     217 ..     493     516 ..     477     522 .. 0.75
   3 !    6.4   0.0    0.0013         6     186     219 ..     582     615 ..     534     626 .. 0.67
   4 !   12.5   0.1   1.8e-05     0.082       6      97 ..     585     694 ..     581     822 .. 0.70
   5 !    4.6   0.0    0.0047        21     138     160 ..     955     977 ..     820     991 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.11
         SGL  70 geletladeeedekpllrfNDgvvdpdGrlwfGtmgdeeakgeevgalyrldpdg 124
                 g+l+ +a++     ++    ++  d+++ + + +m+++++++e    ly +d ++
  EFC37217.1 130 GDLQLIAKSS--S-DSFVCEEVSLDKANWVSISDMKYSREGME--EVLYLVDSKK 179
                 5566666653..2.34566666666666666666666666666..4555555442 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.2
         SGL 194 eGnvwvAvwgggkvvrfdpdGkli 217
                  G+ ++A  ++++v++++++G + 
  EFC37217.1 493 LGKTFIADSKNDRVRVISKEGVIS 516
                 578888888999999999998765 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0013
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGkliee 219
                 p ++ v++eG ++ A ++++++++++ + +l+ +
  EFC37217.1 582 PESIYVTEEGDIYFADISNHRIRKWTRKTDLVST 615
                 7777777777777777777777776666655554 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 1.8e-05
         SGL   6 vwdeeegaLlwvDilgqrihrldpatgketv..................ldtpe...svGaiaprkdgrlvvasksglall.dlasgeletladeeede 82 
                 ++++eeg +++ Di + ri +++ +t+  ++                          + G+  + ++g++++ ++++  +   +++g+l tl++  +  
  EFC37217.1 585 IYVTEEGDIYFADISNHRIRKWTRKTDLVSTiagtgvqgssedgilatnS---TidsPSGVYLN-RKGEVYFVESESHKIRkITSEGKLLTLFQVRSPH 679
                 4666899*****************99999998888877777777754432...03324444444.5555555555555444324455666666655444 PP

         SGL  83 kpllrfNDgvvdpdG 97 
                    + +ND v+ ++ 
  EFC37217.1 680 RLIVTSNDEVIVSHD 694
                 455566665555544 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.0047
         SGL 138 GlawspdgktlYlaDsltrkiwa 160
                  la+s+dg  +Y++Ds ++ i +
  EFC37217.1 955 SLAFSNDGLSVYFVDSSNNLIRK 977
                 589999*********99999987 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0017       7.5      45      98 ..     558     610 ..     536     627 .. 0.76
   2 ?    2.2   0.0     0.032   1.5e+02      67     115 ..     635     686 ..     619     711 .. 0.77
   3 !    7.6   0.0   0.00072       3.2      60     100 ..     772     812 ..     736     823 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0017
  Phytase-like  45 gkveitevtplkdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdadG 98 
                   + +  +++t + + dg++ ++ ++ pE+i v+++g++++++  +++i++ +++ 
    EFC37217.1 558 EVMVGNRQTSF-NGDGKKGNETSIGPESIYVTEEGDIYFADISNHRIRKWTRKT 610
                   44444444444.556899999*************************99987764 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.032
  Phytase-like  67 glDpEgiav.apdgtfwvssEggpfilefdadGkllrelpl..paellpaas 115
                   ++D+ + ++ +++g++++++   + i++++ +Gkll+ +++  p +l ++++
    EFC37217.1 635 TIDSPSGVYlNRKGEVYFVESESHKIRKITSEGKLLTLFQVrsPHRLIVTSN 686
                   555544445499***********************88776644777766655 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.00072
  Phytase-like  60 gapfpkkglDpEgiavapdgtfwvssEggpfilefdadGkl 100
                    ++++ + +D+ +++v+pd+++++++  ++ i++++ dG +
    EFC37217.1 772 LNALEARFMDISSVVVSPDNELFIADSMDHTIRKVSSDGIV 812
                   333444667*****************************965 PP

>> CD34_antigen  CD34/Podocalyxin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   7.1e-05      0.32     109     142 ..    1036    1069 ..    1024    1100 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 7.1e-05
  CD34_antigen  109 ialvtsg.lllaiLlvagyYgclhrRlskskager 142 
                     ++ +++ l+l+i+l +++Y  l++R s++ + ++
    EFC37217.1 1036 LLVTIGSvLILSIILAGAIYYLLKNRESQK-HYQK 1069
                    233333326677888889999********5.5554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1106 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       559  (0.0311785); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.90u 0.33s 00:00:01.23 Elapsed: 00:00:00.53
# Mc/sec: 6241.65
//
Query:       EFC37218.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.50
# Mc/sec: 777.23
//
Query:       EFC37219.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-07   31.7   1.2    2.6e-07   30.6   1.2    1.6  1  PX        PX domain
  ------ inclusion threshold ------
      0.021   14.7   0.9      0.072   13.0   0.1    2.2  2  F-box     F-box domain
       0.11   13.1   2.5       0.28   11.7   2.5    1.7  1  SPT2      SPT2 chromatin protein


Domain annotation for each model (and alignments):
>> PX  PX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   1.2   4.4e-11   2.6e-07       6     111 ..     292     409 ..     286     411 .. 0.87

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 4.4e-11
                 EEEEEEEEETTSSEEEEEEEEEETTS..SSEEEEEEEHHHHHHHHHHHHHHHT..............TSTSTSSSTSGSSSSSCTTSHHHHHHHHHHHH CS
          PX   6 vsvleretsgskkhsyylyevelktg..akewtvkRrYsdFeeLhskLlrkfp..............rvkiPplPkkvlfgsvrkkdeefiekrrkgLe 88 
                 +++ ++ +  +k++ +y++ev+l+ +     + ++++Y +F  L + + ++ +              +++  pl +++lf     + +e+ie+r++ ++
  EFC37219.1 292 ATIQDSSKTFNKHSCFYIIEVTLNVNgkLLGFRIQKKYTQFKILFDIMCKCVDnnnnrdgtlevnsnERIEFPLKRWSLFT----NPDEIIEERKHVFQ 386
                 3455555558999999**********9999***********************************8655555666666665....58************ PP

                 HHHHHHHTSCHHHHSHHHHHHHH CS
          PX  89 eyLqrllnhpelrnsevlteFLe 111
                 ++L+ +++h+ ++ ++++++F+ 
  EFC37219.1 387 KMLNLIVEHSNIFHNSEIYTFFY 409
                 *********************95 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1      0.57   3.4e+03      11      19 ..      29      37 ..      28      38 .. 0.90
   2 ?   13.0   0.1   1.2e-05     0.072      22      40 ..     147     165 ..     142     172 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.57
                HHHHHHTS- CS
       F-box 11 lrhILerLp 19
                l+hI+ +L+
  EFC37219.1 29 LEHIFLYLS 37
                89****997 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 1.2e-05
                 HHHHHCTT-HHHHHHHTTH CS
       F-box  22 dllalrrVSkgwrilidsd 40 
                 + l lr V+k+w+++id+ 
  EFC37219.1 147 HFLTLREVCKSWKKYIDER 165
                 6799************975 PP

>> SPT2  SPT2 chromatin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   2.5   4.8e-05      0.28      10      53 ..      55      97 ..      50     106 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.8e-05
        SPT2 10 krrseeeeedsdlddfieddeeeeeerrryarseIwaifnkdkk 53
                ++ +++++++++ld+ ++dd+e    +r++  ++  +if+++++
  EFC37219.1 55 NQTNDSNDQEDELDSNVDDDDEFL-YYRSEIVDQMSEIFERRRS 97
                677889999******987777755.56679999*********99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       705  (0.0393218); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 2728.49
//
Query:       EFC37220.1  [L=337]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
   1.5e-109  366.4  10.2   1.8e-109  366.1  10.2    1.0  1  G-alpha    G-protein alpha subunit
    4.2e-12   45.9   1.7    1.2e-08   34.6   0.5    2.9  2  Arf        ADP-ribosylation factor family
    2.4e-05   23.8   1.6     0.0077   15.6   1.0    2.5  2  Gtr1_RagA  Gtr1/RagA G protein conserved region
     0.0019   18.4   0.9          2    8.6   0.0    3.0  3  Roc        Ras of Complex, Roc, domain of DAPkinase
      0.006   16.2   1.0      0.049   13.2   0.2    2.3  2  GTP_EFTU   Elongation factor Tu GTP binding domain
  ------ inclusion threshold ------
      0.021   14.9   0.1        5.4    7.1   0.0    2.6  2  MMR_HSR1   50S ribosome-binding GTPase
       0.12   12.1   0.0       0.29   10.9   0.0    1.7  1  AAA_29     P-loop containing region of AAA domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  366.1  10.2  7.1e-113  1.8e-109      18     354 .]       6     326 ..       2     326 .. 0.95

  Alignments for each domain:
  == domain 1  score: 366.1 bits;  conditional E-value: 7.1e-113
                 XXE..EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH....... CS
     G-alpha  18 rkkkrevkllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliaklssat 116
                 r +++e+kllllG++eSGKsT++kq+++++++g++e el  + + i++n+++s++ +++a   l++++    e++e++++++++++++++   +     
  EFC37220.1   6 RLNDSEIKLLLLGAGESGKSTLFKQIRIIHDGGYNEHELLGFVDTIHSNVLQSMQALIQASHDLNIPI----ENPENRQKAAKILELQNDSLLN----- 95 
                 445689**************************************************************....9***********9999985432..... PP

                 ...HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCGCCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEEEEEE-SSHHH CS
     G-alpha 117 eeeqeiefnpraevgedikaLwndpgiqelyerrnkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdsklefrivdvgGqrse 215
                     + + n+   +++d+k+Lw+d giq +y+rrn+++l+d++eyF  +l+ri+++dY+p+++D+l++r+kt+G+ +++fe+d +l++ ++dvgGqr+e
  EFC37220.1  96 ---INKVYNE--AFANDLKDLWEDAGIQTVYKRRNEFQLLDSTEYFYTNLKRISQKDYVPNQQDVLHCRIKTTGVVQLRFEID-ELKMLLIDVGGQRNE 188
                 ...6677777..9999*******************************************************************.*************** PP

                 HHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS.-GGGCCTT--H.CCHHHHHHHHHH CS
     G-alpha 216 rkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg.klskyfpsyegrkndlesvlkylr 313
                 rkkW+++fddv+aiiF++slsefdq +yed+++nrl+es+ lF+ei+n+ ++++tp+iLflnK D++++Kl++   ++++fp++eg++ +l+++++ ++
  EFC37220.1 189 RKKWIHCFDDVTAIIFVASLSEFDQKCYEDDSTNRLDESILLFDEIVNSHFFEKTPVILFLNKSDLFSKKLNERgVFKRVFPEFEGDDTNLRQCADHIK 287
                 ***********************************************************************6666************************ PP

                 HHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHHHHHH CS
     G-alpha 314 nkFeeihkeksnnrrkiythftsatdtkevqkviesvrdti 354
                 +kF++  +   ++++ki + +t+atdt+++++v+++v++ i
  EFC37220.1 288 DKFISRVED--KDEKKIDVRITCATDTEAIKTVFDNVKEAI 326
                 *****9875..78889*********************9976 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0   0.00027      0.69       9      35 ..       6      32 ..       1      63 [. 0.84
   2 !   34.6   0.5   4.7e-12   1.2e-08      43     130 ..     160     257 ..     149     326 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00027
                TT.TTEEEEEEEESTTSSHHHHHHHHH CS
         Arf  9 klkkkelrilllGLDnaGKtTilkklk 35
                +l++ e+++lllG  ++GK+T+ k+++
  EFC37220.1  6 RLNDSEIKLLLLGAGESGKSTLFKQIR 32
                56689*****************99865 PP

  == domain 2  score: 34.6 bits;  conditional E-value: 4.7e-12
                 SSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT..........THHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTS CS
         Arf  43 vPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre..........RleeakeeLkalleeeelkevallvlaNKqDlpea 130
                 + T+g    + ei +lk+ + DvGGq++ R+ W + f++++a+ifv   ++ +          Rl+e+   ++++++++  ++ +++++ NK Dl + 
  EFC37220.1 160 IKTTGVVQLRFEIDELKMLLIDVGGQRNERKKWIHCFDDVTAIIFVASLSEFDqkcyeddstnRLDESILLFDEIVNSHFFEKTPVILFLNKSDLFSK 257
                 5577777778899*********************************86543221222223344*******************************9654 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.0    0.0017       4.4       1      19 [.      13      31 ..      13      95 .. 0.78
   2 !   15.6   1.0     3e-06    0.0077      23     131 ..     148     262 ..     138     313 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0017
   Gtr1_RagA  1 kvLLmGksgsGKtsmrsii 19
                k+LL+G ++sGK+++ + i
  EFC37220.1 13 KLLLLGAGESGKSTLFKQI 31
                89***********996532 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 3e-06
   Gtr1_RagA  23 ylardtlrlgatidve.ksevrf.lgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDve...........sreleedletlkeilealrqy 108
                 y++++   l   i+++   ++rf  ++l++ l+D+gGq++  ++       + f +v ++i+V   +           ++ l+e++  + ei++   ++
  EFC37220.1 148 YVPNQQDVLHCRIKTTgVVQLRFeIDELKMLLIDVGGQRNERKKW-----IHCFDDVTAIIFVASLSefdqkcyeddsTNRLDESILLFDEIVNS--HF 239
                 5555555555444433123444426899**********9988775.....799**********88777777788776333478888888888764..56 PP

   Gtr1_RagA 109 speakvfvlihKmDliqederee 131
                  ++  v  +++K Dl +++ +e+
  EFC37220.1 240 FEKTPVILFLNKSDLFSKKLNER 262
                 788999**********9887664 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0   0.00079         2       1      19 [.      13      31 ..      13      64 .. 0.89
   2 ?   -2.6   0.0       2.4   6.1e+03      42      71 ..      94     122 ..      77     131 .. 0.59
   3 !    7.4   0.1     0.002         5      16     119 ..     140     253 ..     138     254 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00079
                EEEEESSTTSSHHHHHHCH CS
         Roc  1 KvvlvGdsgvGKtsllkrf 19
                K++l+G +++GK++l+k++
  EFC37220.1 13 KLLLLGAGESGKSTLFKQI 31
                89**************986 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.4
                 GGSGGCTTBTTTTCEEEEEEEE-SGGCTTT CS
         Roc  42 tkikgvendkkvkkvklniWDtaGqerfrs 71 
                  +i++v n+   +++k ++W  aG + +++
  EFC37220.1  94 LNINKVYNEAFANDLK-DLWEDAGIQTVYK 122
                 4555555554444333.7788888655554 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.002
                 HHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE..........GHHHHCHHH...HHHH CS
         Roc  16 lkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd..........srssenlke...Wlke 101
                 lkr+ ++++ ++++  + + ++t+ v++++      +++++k+ + D++Gq + r+   + + +  ++i+v            ++s ++l+e    ++e
  EFC37220.1 140 LKRISQKDYVPNQQDVLHCRIKTTGVVQLR-----FEIDELKMLLIDVGGQRNERKKWIHCFDDVTAIIFVASlsefdqkcyeDDSTNRLDEsilLFDE 233
                 678899999999999999999988876554.....356789999*******998886655566666666665432332333221122334432223444 PP

                 HHHH..CSSS-EEEEEE-TT CS
         Roc 102 lkkv..agkspvilvgnkiD 119
                 + +    +k+pvil  nk D
  EFC37220.1 234 IVNShfFEKTPVILFLNKSD 253
                 43321245677888888877 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.11   2.9e+02       7      25 ..      15      33 ..      10      53 .. 0.79
   2 !   13.2   0.2   1.9e-05     0.049     121     191 ..     241     325 ..     231     328 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.11
                EEEESTTSSHHHHHHHHHH CS
    GTP_EFTU  7 giighvDhGKtTLtdrLly 25
                 ++g  ++GK+TL  ++  
  EFC37220.1 15 LLLGAGESGKSTLFKQIRI 33
                66778899*****998864 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 1.9e-05
                 TTTEEEEEEESCGST....................HHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHHHHHH CS
    GTP_EFTU 121 egvpiivfiNKmDrl....................kaelkeiveevkqklsrkeeklekygekgekevpvvfgSalkgegvktllealvel 191
                 e++p+i+f+NK D                      +++l+++++ +k+k+      ++ ++ k+ek++ v  ++a + e++kt+++ + e 
  EFC37220.1 241 EKTPVILFLNKSDLFskklnergvfkrvfpefegdDTNLRQCADHIKDKF------ISRVEDKDEKKIDVRITCATDTEAIKTVFDNVKEA 325
                 7899***********99888888888888888888888888888888888......77776666789****************99998765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.0    0.0084        22       3      19 ..      15      31 ..      13      43 .. 0.88
   2 ?    7.1   0.0    0.0021       5.4      32     114 .]     161     251 ..     140     251 .. 0.66

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0084
                EEEESTTSSHHHHHHHH CS
    MMR_HSR1  3 aivGrpNvGKStLinal 19
                +++G   +GKStL++++
  EFC37220.1 15 LLLGAGESGKSTLFKQI 31
                6899999*******986 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0021
                 SSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT........TTCSHHHHHHHHHHHHH.......TTSEEEEEEES CS
    MMR_HSR1  32 tTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas........eeklkpldeeleellee.......akkplilvlnk 114
                 +T+ +++ r+++++ ++ l+D+ G         +++k++    + + +i++v ++s        +++ ++lde++  +  e       +k p+il lnk
  EFC37220.1 161 KTTGVVQLRFEIDELKMLLIDVGG-QR------NERKKWIHCFDdVTAIIFVASLSefdqkcyeDDSTNRLDESILLFD-EivnshffEKTPVILFLNK 251
                 6778888889999999********.33......3444444433327889999988866644443222333444444443.2577778888888888887 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00011      0.29      23      39 ..      11      28 ..       4      41 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00011
      AAA_29 23 g.atlltGpsGsGKSTll 39
                +   ll G+ +sGKSTl+
  EFC37220.1 11 EiKLLLLGAGESGKSTLF 28
                44689***********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (337 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1031  (0.0575046); expected 358.6 (0.02)
Passed bias filter:                      577  (0.0321825); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 2118.79
//
Query:       EFC37221.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.5e-19   69.1   0.0      6e-19   68.7   0.0    1.1  1  Abhydrolase_3  alpha/beta hydrolase fold
    8.1e-11   41.4   0.0    3.5e-10   39.3   0.0    1.9  1  Say1_Mug180    Steryl acetyl hydrolase
      4e-06   26.0   0.0      0.025   13.5   0.0    2.1  2  COesterase     Carboxylesterase family
  ------ inclusion threshold ------
       0.15   11.6   0.0        2.8    7.4   0.0    2.2  2  DUF900         Alpha/beta hydrolase of unknown function (DUF9


Domain annotation for each model (and alignments):
>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.7   0.0   1.3e-22     6e-19       1     133 [.     143     273 ..     143     299 .. 0.86

  Alignments for each domain:
  == domain 1  score: 68.7 bits;  conditional E-value: 1.3e-22
                    EEEE--STTTS--TTTTHHHHHHHHHHHTSEEEEEE---TTTS-TTHHHHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHHHHHHHHHHHHHTT CS
  Abhydrolase_3   1 lvyfHGGGfvlgsldthdalcrelakelgavvvsvdYrlAPehpfPaavedalaalrwlaeqawelgadpsrivlaGdSaGGnlaaavalrardeg 96 
                    l+++HGGGf +gs  ++  l+  ++++ g+ v+ vdY l+P+  +   + ++l  ++ + ++   lg++p+ ++l+GdSaGGnl++++++ +++++
     EFC37221.1 143 LIFIHGGGFFFGSTHSYAGLFIPFVEKFGINVYLVDYGLSPKVDYKEIFPEVLGEVKTAISE---LGLNPELVTLGGDSAGGNLVMNTLRFLKQSN 235
                    689***********************************************999988888887...9****************************98 PP

                    ---...EEEEEEESE-SSTSSTTSHHHHHCHHTTTSSSSC CS
  Abhydrolase_3  97 epk...vagqvliyPvtdlertesesikkaeeladgpllt 133
                    +p    ++ ++l++P+ dl   e++si  a+ ++++  l+
     EFC37221.1 236 SPLysqLNNILLMSPWCDL-CLETKSIV-AAGNRNEISLS 273
                    887999***********99.66667773.32333334444 PP

>> Say1_Mug180  Steryl acetyl hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.3   0.0   7.8e-14   3.5e-10     108     243 ..     129     259 ..      81     326 .. 0.71

  Alignments for each domain:
  == domain 1  score: 39.3 bits;  conditional E-value: 7.8e-14
  Say1_Mug180 108 vwlrkvpetfdPkvDpvllylHGGgfalklipvtlvfLsnlrklfpdmailvsDYtvtaakdqskkYplqvleslavydylvkskgf..knvvvlGdS 203
                  vw   + ++ d k  + l+++HGGgf ++ +           ++f  + + ++DY +  + d ++ +p      l   +  +  +g+    v++ GdS
   EFC37221.1 129 VW---ISHKKDAKERKTLIFIHGGGFFFGSTHSYAGLFIPFVEKFG-INVYLVDYGLSPKVDYKEIFPEV----LGEVKTAISELGLnpELVTLGGDS 218
                  44...3567889999****************999888888899996.78999*****9966666666665....444445555555511569999*** PP

  Say1_Mug180 204 aGGnlvLslllklsklnkvvlPk..kaiaiSPWlnltildek 243
                  aGGnlv++ l  l++ n +++ +  ++ ++SPW++l  l+ k
   EFC37221.1 219 AGGNLVMNTLRFLKQSNSPLYSQlnNILLMSPWCDLC-LETK 259
                  *********************96447899******98.3333 PP

>> COesterase  Carboxylesterase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.0   5.6e-06     0.025      91     128 ..     128     163 ..     127     181 .. 0.78
   2 !   10.3   0.0     5e-05      0.22     173     200 ..     198     225 ..     195     259 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.6e-06
                 EEEEESSSSSTTSSEEEEEEE--STTTS-BGCGS-THH CS
  COesterase  91 nvytPkekkeakkklPVlVwihGggfqtgsaseydgsa 128
                 nv+  ++ k+ak++   l++ihGggf +gs ++y g +
  EFC37221.1 128 NVWISHK-KDAKER-KTLIFIHGGGFFFGSTHSYAGLF 163
                 8999654.444444.68***************998865 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 5e-05
                 HHHHGGGGTEEEEEEEEEEETHHHHHHH CS
  COesterase 173 VkenIasFGGdpervtlfGesAGaasvs 200
                 Vk+ I++ G +pe vtl G+sAG+ +v 
  EFC37221.1 198 VKTAISELGLNPELVTLGGDSAGGNLVM 225
                 8999********************9996 PP

>> DUF900  Alpha/beta hydrolase of unknown function (DUF900)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0     0.031   1.4e+02       8      27 ..     129     148 ..      78     161 .. 0.84
   2 ?    7.4   0.0   0.00063       2.8      96     147 ..     212     261 ..     195     280 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.031
      DUF900   8 alakelkksaakeilvfvhG 27 
                 +  ++ k +++++ l+f+hG
  EFC37221.1 129 VWISHKKDAKERKTLIFIHG 148
                 44556677888999999998 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.00063
      DUF900  96 ihllaHSmGtwlvlealrqlaieadepaveakikeviLaAPDidvdvfkkql 147
                 ++l   S G  lv+++lr l++++    +  ++++++L++P  d+   +k +
  EFC37221.1 212 VTLGGDSAGGNLVMNTLRFLKQSNS--PLYSQLNNILLMSPWCDLCLETKSI 261
                 6666789*************99997..5899**********99985444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       533  (0.0297284); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.48
# Mc/sec: 2111.25
//
Query:       EFC37222.1  [L=507]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.9e-09   36.0   0.2     0.0021   18.6   0.0    4.7  5  Ank_2     Ankyrin repeats (3 copies)
    0.00036   21.0   0.7        0.6   10.8   0.4    4.1  6  Ank_4     Ankyrin repeats (many copies)
    0.00073   19.8   0.6        0.2   12.3   0.3    4.5  6  Ank_3     Ankyrin repeat
    0.00085   19.6   0.3       0.38   11.1   0.1    3.0  3  Ank_5     Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.3   0.1    0.0068        31      51      72 ..     133     154 ..     102     165 .. 0.71
   2 !   18.6   0.0   4.6e-07    0.0021       1      80 [.     139     254 ..     139     257 .. 0.67
   3 ?    3.3   0.0     0.027   1.2e+02      27      63 ..     267     310 ..     242     321 .. 0.73
   4 !    6.7   0.0    0.0025        11      14      73 ..     361     421 ..     347     429 .. 0.62
   5 ?    1.7   0.0     0.087   3.9e+02       7      37 ..     412     439 ..     405     475 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0068
       Ank_2  51 ndgrtpLhyAarsghleivklL 72 
                 n   + Lh+A+ +++l+++++L
  EFC37222.1 133 NRQFSLLHLACIFNRLDLLEWL 154
                 5577899999999999999998 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 4.6e-07
       Ank_2   1 LhlAakngnlelvklL.l..eg...............adpnk..........ngktaLhyAakngnleivklLleh...........adndgrtpLhyA 60 
                 LhlA+ ++ l+l+++L    ++                              n+ ++L+y+++ g+le++ +L+++            d  g+ p+ +A
  EFC37222.1 139 LHLACIFNRLDLLEWLeAlcCElnicdeinhcpschqR---RenlwstvkdsNDVFPLFYSIEFGSLECCAFLCSQpivrdsqlnlkRDHLGNLPIALA 234
                 89999998889999995356334554444433332220...0233334556799********************97776566644433366******** PP

       Ank_2  61 arsghleivklLlekgadin 80 
                  +++ + +++ L   ga+++
  EFC37222.1 235 LQKKDYVMCDTLRLFGASFD 254
                 99987788887763366555 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.027
       Ank_2  27 ktaLhyAakngnleivklLleh.......adndgrtpLhyAars 63 
                 ++ +h   ++++ e  ++L  h        ++ g++pL+ + + 
  EFC37222.1 267 ESLMHQIMRKQDYEGFRYLATHspkvilkKNQRGESPLFSCLKD 310
                 67778888888889999999988888865558899999988754 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0025
       Ank_2  14 klLlegadpnkngktaLhyAakngnleivklLleh..ad..ndgrtpLhyAarsghleivklLl 73 
                 k Ll  ++ n +g+++L+ +++  + e  klL+++   +  ++g+    + ++ + ++++k L+
  EFC37222.1 361 KALL--SRNN-FGRNVLMESVIMHDFESSKLLCKFlmRNylSEGNARFSAGVSMNKYNFLKELV 421
                 2333..2323.88999998888888888888888775335455664444555447788888888 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.087
       Ank_2   7 ngnlelvklLlegadpnkngktaLhyAakng 37 
                 n+ ++++k L++ +d+  +g+t+ +yA + +
  EFC37222.1 412 NK-YNFLKELVFDKDI--TGMTIFFYAFSTT 439
                 33.4588899855555..5999999998764 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.1   0.00016      0.72      35      54 ..     135     154 ..     122     155 .. 0.84
   2 !   10.8   0.4   0.00013       0.6       4      54 ..     138     208 ..     137     209 .. 0.65
   3 ?    0.8   0.0      0.18   8.1e+02       5      20 ..     193     208 ..     190     240 .. 0.73
   4 ?    3.3   0.0      0.03   1.3e+02       3      49 ..     268     316 ..     266     319 .. 0.81
   5 ?   -2.1   0.0       1.5   6.7e+03      29      54 ..     365     389 ..     353     389 .. 0.71
   6 ?   -3.3   0.0       3.3   1.5e+04      32      42 ..     425     435 ..     416     438 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00016
       Ank_4  35 GetalhiAakrgnveilklL 54 
                 ++++lh A+ +++++ l++L
  EFC37222.1 135 QFSLLHLACIFNRLDLLEWL 154
                 78999999999999999998 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00013
       Ank_4   4 aLhyaaisgrlelvrlLlekgad.......inaqdnrsGet...............alhiAakrgnveilklL 54 
                 +Lh a+i++rl+l+++L             in++ +++++                +l + + +g++e+  +L
  EFC37222.1 138 LLHLACIFNRLDLLEWLE-ALCCelnicdeINHC-PSCHQRrenlwstvkdsndvfPLFYSIEFGSLECCAFL 208
                 799999999999999985.332234455677776.66655444445556666666788888888888877766 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.18
       Ank_4   5 LhyaaisgrlelvrlL 20 
                 L+y +++g le++++L
  EFC37222.1 193 LFYSIEFGSLECCAFL 208
                 5555566666666665 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.03
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAa..krgnve 49 
                 +++h+ + ++++e  r+L  + + +   +n +Ge++l  ++  kr+n++
  EFC37222.1 268 SLMHQIMRKQDYEGFRYLATHSPKVILKKNQRGESPLFSCLkdKRNNYK 316
                 56888888999999999998876655556***********988777764 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 1.5
       Ank_4  29 aqdnrsGetalhiAakrgnveilklL 54 
                  + n+ G++ l   + + ++e  klL
  EFC37222.1 365 SR-NNFGRNVLMESVIMHDFESSKLL 389
                 45.78888888888888887776665 PP

  == domain 6  score: -3.3 bits;  conditional E-value: 3.3
       Ank_4  32 nrsGetalhiA 42 
                 ++ G+t + +A
  EFC37222.1 425 DITGMTIFFYA 435
                 55688888877 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.3   4.4e-05       0.2       3      27 ..     136     159 ..     134     163 .. 0.81
   2 ?   -0.5   0.0      0.67     3e+03       5      23 ..     192     210 ..     191     214 .. 0.83
   3 ?   -3.5   0.0         4   1.8e+04       2      22 ..     227     247 ..     227     254 .. 0.68
   4 ?    0.0   0.0      0.45     2e+03       3      23 ..     267     287 ..     267     292 .. 0.85
   5 ?   -3.3   0.0         4   1.8e+04       2      10 ..     300     308 ..     299     319 .. 0.76
   6 ?   -0.3   0.0      0.59   2.6e+03       2      24 ..     370     396 ..     369     402 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.4e-05
       Ank_3   3 etpLhlAarsgnleivkfLlenkga 27 
                  ++LhlA+ +++l+++++L     +
  EFC37222.1 136 FSLLHLACIFNRLDLLEWLEA-LCC 159
                 589***************966.555 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.67
       Ank_3   5 pLhlAarsgnleivkfLle 23 
                 pL++ +++g+le + fL+ 
  EFC37222.1 192 PLFYSIEFGSLECCAFLCS 210
                 899********97877765 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 4
       Ank_3   2 GetpLhlAarsgnleivkfLl 22 
                 G+ p+ lA+   ++ +++ L 
  EFC37222.1 227 GNLPIALALQKKDYVMCDTLR 247
                 667777888888887777765 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.45
       Ank_3   3 etpLhlAarsgnleivkfLle 23 
                 e+++h+ +r +++e  ++L  
  EFC37222.1 267 ESLMHQIMRKQDYEGFRYLAT 287
                 6899*********99999976 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 4
       Ank_3   2 GetpLhlAa 10 
                 Ge+pL+ ++
  EFC37222.1 300 GESPLFSCL 308
                 899998655 PP

  == domain 6  score: -0.3 bits;  conditional E-value: 0.59
       Ank_3   2 GetpLhlAarsgnle....ivkfLlen 24 
                 G++ L++ +   ++e    ++kfL +n
  EFC37222.1 370 GRNVLMESVIMHDFEssklLCKFLMRN 396
                 889999777777774455579999885 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.1   8.4e-05      0.38      17      47 ..     136     166 ..     131     171 .. 0.83
   2 !    5.5   0.0    0.0051        23      13      56 .]     186     234 ..     167     234 .. 0.83
   3 ?   -3.6   0.0       3.6   1.6e+04      11      21 ..     365     375 ..     360     378 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 8.4e-05
       Ank_5  17 ntpLhvAakygaadvvrlLlargadlnltds 47 
                 ++ Lh+A+  +++d++++L a  + ln++d+
  EFC37222.1 136 FSLLHLACIFNRLDLLEWLEALCCELNICDE 166
                 589****************888888888876 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0051
       Ank_5  13 dgggntpLhvAakygaadvvrlLl....argadlnltdsrG.ltaldlA 56 
                 d + + pL ++++ g+++++ +L+     r + lnl+ ++  ++++ lA
  EFC37222.1 186 DSNDVFPLFYSIEFGSLECCAFLCsqpiVRDSQLNLKRDHLgNLPIALA 234
                 4455599*****************9999999999999999888887766 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 3.6
       Ank_5  11 rldgggntpLh 21 
                  ++++g ++L+
  EFC37222.1 365 SRNNFGRNVLM 375
                 56788888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1024  (0.0571142); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 3002.14
//
Query:       EFC37223.1  [L=890]
Description: hypothetical protein NAEGRDRAFT_59796 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      2e-07   30.6   0.0    8.2e-06   25.5   0.0    2.7  2  RCC1_2      Regulator of chromosome condensation (RCC1) repea
     0.0017   19.0   0.1          4    8.1   0.0    3.4  3  RCC1        Regulator of chromosome condensation (RCC1) repea
  ------ inclusion threshold ------
      0.012   15.3   0.2      0.091   12.5   0.0    2.2  2  PLN_propep  Protealysin propeptide
       0.11   12.3   4.9       0.26   11.0   1.6    2.6  2  dCache_1    Cache domain


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.5   0.0   1.8e-09   8.2e-06       1      30 []      64      93 ..      64      93 .. 0.97
   2 ?    2.2   0.0     0.037   1.6e+02       1      26 [.     112     141 ..     112     145 .. 0.82

  Alignments for each domain:
  == domain 1  score: 25.5 bits;  conditional E-value: 1.8e-09
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30
                +k++ +GdyH+++L++dG+ +++G+ + GQ
  EFC37223.1 64 IKKIVCGDYHAIFLLNDGTAFGYGQRTEGQ 93
                799***********************9999 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.037
      RCC1_2   1 VksvsaGdyH.scaLtedGe...VlcWGsN 26 
                 +++v +G+++ +c ++ +     ++++G+N
  EFC37223.1 112 IEDVYCGSSFtYCLIRKSKCefkMVSFGQN 141
                 68999**85549999999988999999987 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0     0.003        13      36      50 .]      63      77 ..      50      77 .. 0.84
   2 !    8.1   0.0    0.0009         4       1      50 []      80     125 ..      80     125 .. 0.80
   3 ?   -0.3   0.0      0.38   1.7e+03      24      45 ..     173     193 ..     137     198 .. 0.64

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.003
                -EEEEEEETTEEEEE CS
        RCC1 36 rvvkvacGddhtval 50
                 ++k++cGd+h ++l
  EFC37223.1 63 GIKKIVCGDYHAIFL 77
                689********9886 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0009
                 TTEEEEEE--GGGTTSSSS-..--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt..esvlvPtkveglsgnrvvkvacGddhtval 50 
                 dG  ++ G+ ++GqL    +  + v   ++++++   ++ +v cG+++t +l
  EFC37223.1  80 DGTAFGYGQRTEGQLMVDRNskQHV---VEIPLS---NIEDVYCGSSFTYCL 125
                 8999***********9988842333...555554...9***********886 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.38
                 EEEEE-GGGTTS-EEEEEEETT CS
        RCC1  24 lvPtkveglsgnrvvkvacGdd 45 
                 + P++ ++++ + v +v cG+ 
  EFC37223.1 173 SQPMEFPPPN-EIVLDVKCGAG 193
                 3488887776.36777999986 PP

>> PLN_propep  Protealysin propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0     2e-05     0.091       2      18 ..     544     558 ..     543     568 .. 0.80
   2 ?   -0.3   0.1       0.2   8.9e+02      28      39 ..     856     867 ..     851     870 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2e-05
  PLN_propep   2 siIPPyiLrrIidngde 18 
                 s++PPyiL++I ++  e
  EFC37223.1 544 SFVPPYILEQIQNS--E 558
                 89*********998..3 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.2
  PLN_propep  28 LeHVqslmakvk 39 
                 L+H+  +m +++
  EFC37223.1 856 LNHLRKVMNNSY 867
                 9*******9986 PP

>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   1.6   5.9e-05      0.26     123     191 ..     308     383 ..     199     454 .. 0.67
   2 ?    1.6   0.1     0.044     2e+02      38      75 ..     833     871 ..     809     887 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 5.9e-05
    dCache_1 123 isdpy.vdqtggkpvitiavpiy.......ddsgkfiGvlaadldldnlqdllsniklgetgyvfivdsdGniiahp 191
                 +sd+   ++ +g+ +i+++  ++       ++++  +Gv+ ++l+l  + ++ls+i+l ++gyv + d++G+++  +
  EFC37223.1 308 VSDLAaLSA-EGVMTIYYSHLLFnptlyqkNRTRDMVGVAKINLSLKAVANYLSTIRLLGSGYVVLGDNSGTYLGAS 383
                 444443333.47777777777774444333467788*************************************9765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.044
    dCache_1  38 snps.lqdlleepnraneasreslqallksilksnpdis 75 
                  ++s l ++l+++n+++   ++ l++l k +++s+++is
  EFC37223.1 833 KSISvLENWLNSNNKDSGTVEKLLNHLRKVMNNSYDNIS 871
                 454448999*99999666655555555555667777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (890 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       866  (0.0483016); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.80u 0.29s 00:00:01.09 Elapsed: 00:00:00.50
# Mc/sec: 5387.92
//
Query:       EFC37224.1  [L=227]
Description: hypothetical protein NAEGRDRAFT_81977 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-16   59.5   0.4    4.5e-16   58.9   0.4    1.3  1  DUF4476   Domain of unknown function (DUF4476)


Domain annotation for each model (and alignments):
>> DUF4476  Domain of unknown function (DUF4476)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.9   0.4   2.5e-20   4.5e-16       2      91 .]      59     152 ..      58     152 .. 0.97

  Alignments for each domain:
  == domain 1  score: 58.9 bits;  conditional E-value: 2.5e-20
     DUF4476   2 msdksfeqlveklkka.sfdddklklleqalank..aftcsqvvqllklfsfdddrlkalkllapnivDkqns.etiidsftfssdkkkareil 91 
                 +s+++ e l+++++++  fdd+k++ ++++l++k  ++ ++q+++++ +++f+++r+ +++ l p i+D +   ++ii+++ f +dk k+++++
  EFC37224.1  59 LSAEQYEVLLNQVQHEiDFDDEKMNHITAYLTEKnvCIDTEQALAFIGTIHFSNTRIVFIERLLPFIIDLKVGkKKIIETIGFYNDKIKIKKLI 152
                 57899***********9************999999*******************************************************9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       643  (0.0358637); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1515.74
//
Query:       EFC37225.1  [L=280]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.012   15.6   1.4       0.15   12.0   0.1    2.8  3  Swm2      Nucleolar protein Swm2


Domain annotation for each model (and alignments):
>> Swm2  Nucleolar protein Swm2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0     0.022     4e+02      57     106 ..      42      90 ..      22     102 .. 0.74
   2 ?   12.0   0.1   8.6e-06      0.15      15      94 ..     147     227 ..     140     240 .. 0.92
   3 ?   -0.7   0.0     0.076   1.4e+03      17      41 ..     243     262 ..     232     274 .. 0.68

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.022
        Swm2  57 vvkrcldlwlvlkgkeYklkeeeslsNliieevdvsevksselerlefde 106
                  +k c+ ++++++   Y + ++++++   +  v  s+  ++++ +++ ++
  EFC37225.1  42 EYKSCSSFHTCINSSFYWQ-TPSDIKDGKVSRVASSSSSNNQKRKTKSKD 90 
                 4788999999999999998.788887777777777777666666655444 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 8.6e-06
        Swm2  15 splLspyyeaiakdeelkkkalkkCkevfekweekddavdkevvkrcldlwlvlkgkeYkl.keeeslsNliieevdvsev 94 
                 ++ ++ +y++i++  + +k+  +  ++++e++ +k+ +v++ +v  + + +++l  +e+++ k+     Nli +++ v++ 
  EFC37225.1 147 AKSMILHYQNIEALFRENKENRQVLQYLLEQFTKKSLDVSQSIVGYIGRGLSLLYLHEFEKsKTVFLTLNLIDNQMGVEKG 227
                 5678999******************************************************9*************999875 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.076
        Swm2  17 lLspyyeaiakdeelkkkalkkCke 41 
                 +Ls+ y++ +++++lk+     C++
  EFC37225.1 243 YLSRVYSKLNQQDQLKS-----CQK 262
                 46677777777777665.....433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       951  (0.0530426); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 1955.53
//
Query:       EFC37226.1  [L=497]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-08   32.8  10.9    1.4e-07   31.5  10.9    1.7  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
       0.11   12.6   4.4      0.091   12.8   0.6    2.3  2  TERB2     Telomere-associated protein TERB2
       0.31   12.1   7.1       0.12   13.5   0.9    2.4  2  SPG4      Stationary phase protein 4
       0.49   10.5   3.3         15    5.8   0.2    3.1  3  DUF382    Domain of unknown function (DUF382)
       0.82    9.9  11.5      0.052   13.8   5.9    1.9  2  DUF2072   Zn-ribbon containing protein
        2.9    8.3   7.6       0.49   10.8   1.7    2.2  2  DUF1178   Protein of unknown function (DUF1178)


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.5  10.9   4.7e-11   1.4e-07       2      39 ..      14      50 ..      13      51 .. 0.89

  Alignments for each domain:
  == domain 1  score: 31.5 bits;  conditional E-value: 4.7e-11
                S-HHHHHCT---ST.SSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCda.kkPaCsnCkklnleCtfysesskr 39
                +C +Crk+++KCd+  k+ CsnC  ++++C  y ++ ++
  EFC37226.1 14 SCMRCRKHHRKCDRnPKG-CSNCGNSGVKCI-YADQLQN 50
                9************96677.************.8888776 PP

>> TERB2  Telomere-associated protein TERB2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.6   3.1e-05     0.091     127     182 ..      47     114 ..      37     137 .. 0.79
   2 ?    0.4   0.2       0.2   5.9e+02     107     168 ..     434     467 ..     415     494 .. 0.47

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.1e-05
       TERB2 127 iakdslleekeeqasklaksaeksatstsksekqlcsel....k........eyPvnnvvtgyvside 182
                 + ++s+++ek++++s++++ +++++t t+++   +++++    +        +y vnn +++y  i++
  EFC37226.1  47 QLQNSQHQEKKDEQSQQQNTQQQQQTMTPQTLVDVYFSIlcgtHpliekekfKYFVNNCLNQYNDIKA 114
                 4567778888888889999999**************999555516666677799********999875 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.2
       TERB2 107 qdnqslveqssevhsaeepeiakdslleekeeqasklaksaeksatstsksekqlcselkey 168
                 +++q+++ + s+ +                            +s+t++ +s ++ +++++ +
  EFC37226.1 434 EMTQTIMRNTSRSA----------------------------SSDTRSTTSSTTNRTQIEAF 467
                 22222222222222............................22233222333333333333 PP

>> SPG4  Stationary phase protein 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.9   3.9e-05      0.12      12      65 ..      19      72 ..      12      81 .. 0.77
   2 ?    1.2   0.7      0.25   7.5e+02      35      87 ..     426     478 ..     421     487 .. 0.53

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.9e-05
        SPG4 12 kKHsknpkivGgnhsNvgesktqylyskEyrepkkkkkkdeeelakaeetsess 65
                 KH ++ +      sN g+s  + +y++  +++++++kkde++ ++++++++++
  EFC37226.1 19 RKHHRKCDRNPKGCSNCGNSGVKCIYADQLQNSQHQEKKDEQSQQQNTQQQQQT 72
                68888999999999***************9999998777777755544444433 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.25
        SPG4  35 ylyskEyrepkkkkkkdeeelakaeetsessseslkeeegaakapnmvdiskl 87 
                 +ly +  +e +++  ++++  a+++++s +ss++++++  a  + +m ++s +
  EFC37226.1 426 LLYQNLIEEMTQTIMRNTSRSASSDTRSTTSSTTNRTQIEAFADDTMREVSSF 478
                 55655555555554444444444444444444444444444455888888865 PP

>> DUF382  Domain of unknown function (DUF382)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.2    0.0049        15      64     109 ..      40      85 ..      19     104 .. 0.78
   2 ?    0.0   0.0      0.29   8.7e+02      61      84 ..     257     280 ..     245     320 .. 0.65
   3 ?    3.3   0.1     0.029        86       4      97 ..     374     464 ..     371     475 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0049
      DUF382  64 ieelrealeekeeekslkekarekvqpklgkldidykkLhdaFfkl 109
                 ++ +  +  +++++++ k+++ ++ + + ++  +  ++L d++f++
  EFC37226.1  40 VKCIYADQLQNSQHQEKKDEQSQQQNTQQQQQTMTPQTLVDVYFSI 85 
                 55555666777888888888999999999999999*******9986 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.29
      DUF382  61 eTgieelrealeekeeekslkeka 84 
                    ie++r++  + e+++  ++ +
  EFC37226.1 257 PGTIEHMRSNSITMENNQMYRQVH 280
                 567999999888888888777643 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.029
      DUF382   4 evvevaDvdakdPvllvklKssknvvpvpshWsskreylsgkrglekkpfelPkfikeTgieelrealeekeeekslkekarekvqpklgkldi 97 
                 ++ve      ++P++ + + ss n+v v      k++  +       k+f+  +++ +  iee+ +++  +++++s  + +r+  ++ +++++i
  EFC37226.1 374 QLVENCIERGTKPMTSTIMTSSGNTVTVDYLSILKKDLKALI--SLAKRFKRVTLLYQNLIEEMTQTI-MRNTSRSASSDTRSTTSSTTNRTQI 464
                 667777778899999999********9999888888866633..344678888999999999999864.4555566667777777776666666 PP

>> DUF2072  Zn-ribbon containing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   5.9   1.7e-05     0.052       1      58 [.      12      70 ..      12     113 .. 0.70
   2 ?   -2.8   0.3       2.4   7.1e+03      43      60 ..     450     467 ..     429     488 .. 0.48

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.7e-05
     DUF2072  1 PHkCtkCekvfedgskeilkGCpsCGgkkFlyvkeeekkedvseeke..elvaeaeeeie 58
                P  C++C k  +  ++   kGC +CG    + +  ++ ++++++ek+  +++++++++ +
  EFC37226.1 12 PYSCMRCRKHHRKCDR-NPKGCSNCGNSGVKCIYADQLQNSQHQEKKdeQSQQQNTQQQQ 70
                899*******999988.689******7755555555544444444441122222222222 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.4
     DUF2072  43 seekeelvaeaeeeieev 60 
                  ++++++ ++++++ie +
  EFC37226.1 450 DTRSTTSSTTNRTQIEAF 467
                 222222233333334433 PP

>> DUF1178  Protein of unknown function (DUF1178)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   1.7   0.00017      0.49      34      77 ..      31      73 ..      18     122 .. 0.77
   2 ?    0.4   0.4      0.26   7.9e+02      48     104 ..     435     491 ..     432     494 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00017
     DUF1178 34 eCpvCgstevekalmaprvakskkkaaeaaeaeaaaaaakaaaa 77
                 C  Cg++ v k + a ++++s+++++++++++++++++++++ 
  EFC37226.1 31 GCSNCGNSGV-KCIYADQLQNSQHQEKKDEQSQQQNTQQQQQTM 73
                6********9.799********9999998888777766666544 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.26
     DUF1178  48 maprvakskkkaaeaaeaeaaaaaakaaaaaekekeleaalaelrrkveknsedVGe 104
                 m+  + ++++++a++++++++++++++++ ++ ++++++++ +++++ +k +e V +
  EFC37226.1 435 MTQTIMRNTSRSASSDTRSTTSSTTNRTQIEAFADDTMREVSSFNDSAVKMAESVDN 491
                 555666666666666666666666666666778888888888888888888888855 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (497 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2724  (0.151933); expected 358.6 (0.02)
Passed bias filter:                      789  (0.0440069); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.48
# Mc/sec: 3097.19
//
Query:       EFC37227.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.15   12.2   0.4       0.61   10.3   0.0    2.0  2  CD225     Interferon-induced transmembrane protein
       0.83    9.5   3.7       0.42   10.4   1.2    1.8  2  DUF4316   Domain of unknown function (DUF4316)


Domain annotation for each model (and alignments):
>> CD225  Interferon-induced transmembrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   6.8e-05      0.61      22      53 ..      65      96 ..      62     101 .. 0.92
   2 ?   -1.1   0.1      0.24   2.2e+03       8      18 ..     105     118 ..     103     130 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 6.8e-05
       CD225 22 ivAlvySvkvrdrkmvGdvegAqsasstAkll 53
                ++Al+yS+k+      G +e A++a+ ++k +
  EFC37227.1 65 MAALFYSIKAICECFTGTMEDAEKAATKSKNY 96
                57***************************976 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.24
       CD225   8 wsifntlf...ccl 18 
                 ws++++ +    c+
  EFC37227.1 105 WSVLVVACyyyLCW 118
                 88888888777777 PP

>> DUF4316  Domain of unknown function (DUF4316)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   1.2   4.6e-05      0.42      12      20 ..      14      22 ..      12      26 .. 0.90
   2 ?   -3.1   0.1      0.75   6.7e+03      22      28 ..      54      60 ..      54      67 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 4.6e-05
     DUF4316 12 tEqNYNMID 20
                +Eq+YNMID
  EFC37227.1 14 LEQDYNMID 22
                8******** PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.75
     DUF4316 22 ilNNgpp 28
                i NN+ +
  EFC37227.1 54 IPNNEDK 60
                6799977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       648  (0.0361426); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2425.85
//
Query:       EFC37228.1  [L=2346]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-34  118.3 241.9    6.9e-05   23.1   7.8   15.9 16  EGF_2     EGF-like domain
    4.1e-26   89.6   3.2     0.0014   18.6   0.0   10.8 10  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.5   0.8         2   1.8e+04       1      12 [.     837     848 ..     837     848 .. 0.83
   2 ?    1.3   0.7     0.051   4.6e+02      22      32 .]    1036    1046 ..    1036    1046 .. 0.93
   3 !   14.0  11.2   5.7e-06     0.051       5      32 .]    1059    1085 ..    1051    1085 .. 0.91
   4 !   13.9   6.4   5.9e-06     0.053       5      32 .]    1098    1124 ..    1094    1124 .. 0.90
   5 !   15.8   9.4   1.5e-06     0.014       5      32 .]    1137    1163 ..    1129    1163 .. 0.89
   6 !   21.8  10.8     2e-08   0.00018       5      32 .]    1176    1202 ..    1168    1202 .. 0.90
   7 !   13.6  10.4   7.3e-06     0.066       4      32 .]    1213    1241 ..    1207    1241 .. 0.87
   8 !   19.1   9.2   1.4e-07    0.0012       6      32 .]    1255    1279 ..    1250    1279 .. 0.94
   9 !   18.0   8.7   3.2e-07    0.0029       5      32 .]    1292    1318 ..    1288    1318 .. 0.91
  10 !   20.9   9.9   3.9e-08   0.00035       5      32 .]    1331    1357 ..    1328    1357 .. 0.92
  11 !   23.1   7.8   7.7e-09   6.9e-05       4      32 .]    1369    1397 ..    1367    1397 .. 0.91
  12 !   19.8  10.8   8.7e-08   0.00078       4      32 .]    1408    1436 ..    1406    1436 .. 0.87
  13 !   14.6  14.5   3.6e-06     0.033       5      32 .]    1449    1475 ..    1441    1475 .. 0.86
  14 !   11.6  13.0   3.1e-05      0.27       1      25 [.    1479    1500 ..    1478    1512 .. 0.84
  15 ?   -0.2   1.9      0.15   1.4e+03      22      32 .]    1514    1524 ..    1508    1524 .. 0.89
  16 ?    2.5   2.1     0.022   1.9e+02       7      32 .]    2193    2218 ..    2190    2218 .. 0.77

  Alignments for each domain:
  == domain 1  score: -4.5 bits;  conditional E-value: 2
       EGF_2   1 CsasdeiCgghG 12 
                 C++s  +Cg +G
  EFC37228.1 837 CPNSTYTCGDNG 848
                 888888999887 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.051
       EGF_2   22 dCdsgyqGktC 32  
                  +C++gy+G +C
  EFC37228.1 1036 SCPTGYYGLNC 1046
                  5*******999 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 5.7e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+g G C ++  +C+Cds++ G +C
  EFC37228.1 1059 SNTCNGFGNCSAPD-VCSCDSSHEGSQC 1085
                  789********999.************* PP

  == domain 4  score: 13.9 bits;  conditional E-value: 5.9e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C ghG C ++   C+C+  y+G +C
  EFC37228.1 1098 SMVCTGHGLCLSLD-TCSCNGDYYGEKC 1124
                  567*******9899.9************ PP

  == domain 5  score: 15.8 bits;  conditional E-value: 1.5e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g+G Cv++  qC+C ++y G+ C
  EFC37228.1 1137 TSVCSGQGNCVEKD-QCSCRNNYLGAMC 1163
                  578********999.***********99 PP

  == domain 6  score: 21.8 bits;  conditional E-value: 2e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G Cv+++ +C Cd gy+G+ C
  EFC37228.1 1176 SNVCSGNGECVSLN-NCTCDEGYYGDLC 1202
                  789********999.8***********9 PP

  == domain 7  score: 13.6 bits;  conditional E-value: 7.3e-06
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+g+G C+ +  qC+C ++y G+ C
  EFC37228.1 1213 NdSSVCSGQGDCIGKD-QCSCRNNYLGAMC 1241
                  35899********666.9**********99 PP

  == domain 8  score: 19.1 bits;  conditional E-value: 1.4e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ghG Cv   G C+C+++y+G +C
  EFC37228.1 1255 NVCSGHGLCV--SGSCQCSDNYFGSNC 1279
                  68********..*************** PP

  == domain 9  score: 18.0 bits;  conditional E-value: 3.2e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C ++  +C+C++gy+G +C
  EFC37228.1 1292 SSVCSGNGICSSFD-ECKCSTGYTGVNC 1318
                  789********999.9**********99 PP

  == domain 10  score: 20.9 bits;  conditional E-value: 3.9e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+ghG C +++ qC+C++g+ G +C
  EFC37228.1 1331 ASVCSGHGLCTSPN-QCSCNQGWNGTYC 1357
                  568********999.************* PP

  == domain 11  score: 23.1 bits;  conditional E-value: 7.7e-09
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  s ++ C+ghG+C++++ +C+C++gy G +C
  EFC37228.1 1369 SvSNVCNGHGSCIAPN-ECSCKQGYLGSSC 1397
                  55789********999.9************ PP

  == domain 12  score: 19.8 bits;  conditional E-value: 8.7e-08
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+ghGtC +++  C+C+s ++G +C
  EFC37228.1 1408 NeSNVCSGHGTCGDLN-SCSCSSDWYGSKC 1436
                  45799*******7677.7************ PP

  == domain 13  score: 14.6 bits;  conditional E-value: 3.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ghG+C ++ +qC C+ +y+G +C
  EFC37228.1 1449 NTVCSGHGSCPST-NQCNCQENYYGTSC 1475
                  789*******755.5************* PP

  == domain 14  score: 11.6 bits;  conditional E-value: 3.1e-05
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCds 25  
                  C   +++C+ghG C  ++GqC+C+s
  EFC37228.1 1479 CD--SNTCNGHGNCS-STGQCQCFS 1500
                  66..579*******7.699****76 PP

  == domain 15  score: -0.2 bits;  conditional E-value: 0.15
       EGF_2   22 dCdsgyqGktC 32  
                  +Cds+++G +C
  EFC37228.1 1514 KCDSNRYGENC 1524
                  6*********9 PP

  == domain 16  score: 2.5 bits;  conditional E-value: 0.022
       EGF_2    7 iCgghGtCvnqcGq.CdCdsgyqGktC 32  
                  +C ++G+ ++++ + C C+sg+   +C
  EFC37228.1 2193 NCLNGGVYNSFT-KmCACKSGFKKIDC 2218
                  477777777777.45*******87777 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   0.0    0.0015        13       1      20 [.      53      73 ..      53      75 .. 0.91
   2 ?    2.6   0.0     0.018   1.6e+02       1      19 [.     259     277 ..     259     283 .. 0.87
   3 !    5.4   0.0    0.0023        21       1      23 [.     465     487 ..     465     490 .. 0.91
   4 !    8.8   0.0    0.0002       1.8       1      22 [.     523     545 ..     523     549 .. 0.89
   5 ?   -2.4   0.0      0.68   6.1e+03       1      15 [.     717     731 ..     717     732 .. 0.87
   6 ?    2.9   0.0     0.015   1.3e+02       3      16 ..     796     809 ..     795     816 .. 0.87
   7 !   18.6   0.0   1.6e-07    0.0014       2      27 ..     856     881 ..     855     882 .. 0.93
   8 !   17.9   0.0   2.5e-07    0.0022       3      27 ..     917     941 ..     915     942 .. 0.90
   9 !    8.0   0.0   0.00036       3.2       2      20 ..     956     975 ..     955     978 .. 0.88
  10 !    6.9   0.0   0.00078       6.9       1      25 [.    1007    1030 ..    1007    1031 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0015
                BSSEEEEEEE.TTTEEEEEEC CS
         NHL  1 fnyPhGvavd.snGdiyVaDs 20
                f +P++ +v+ ++Gd++ +D 
  EFC37228.1 53 FKNPASACVNpKTGDVFLTDA 73
                779*****************5 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.018
                 BSSEEEEEEETTTEEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaD 19 
                 f++P+++ v  nG++++aD
  EFC37228.1 259 FYQPSSLHVQENGNLVIAD 277
                 8999999999********* PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0023
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +n+P  +++d n+++++ D+ n 
  EFC37228.1 465 LNSPKAICLDANDNLIIMDTSNC 487
                 799****************9985 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.0002
                 BSSEEEEEEE.TTTEEEEEECCC CS
         NHL   1 fnyPhGvavd.snGdiyVaDsen 22 
                 f++P++ avd +nGdiy+++++ 
  EFC37228.1 523 FSSPSDCAVDkKNGDIYISENNK 545
                 889****************9986 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 0.68
                 BSSEEEEEEETTTEE CS
         NHL   1 fnyPhGvavdsnGdi 15 
                 +++P+++a  +nGd+
  EFC37228.1 717 LCNPTSIAKHKNGDL 731
                 89******9999987 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.015
                 SEEEEEEETTTEEE CS
         NHL   3 yPhGvavdsnGdiy 16 
                 +P Gv+v++ G+++
  EFC37228.1 796 FPLGVVVTDAGEVI 809
                 8***********97 PP

  == domain 7  score: 18.6 bits;  conditional E-value: 1.6e-07
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                  +P+G+ ++ +G +y+aDs+nhr+++
  EFC37228.1 856 KQPTGLFLTESGVLYIADSGNHRIRK 881
                 68**********************86 PP

  == domain 8  score: 17.9 bits;  conditional E-value: 2.5e-07
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                  P+ v ++++Gd+yVaD++n+ v++
  EFC37228.1 917 TPAAVYITKSGDVYVADTGNNKVRK 941
                 6999*****************9987 PP

  == domain 9  score: 8.0 bits;  conditional E-value: 0.00036
                 SSEEEEEEE.TTTEEEEEEC CS
         NHL   2 nyPhGvavd.snGdiyVaDs 20 
                   P+G+ vd sn+d+y++D+
  EFC37228.1 956 DLPTGLFVDeSNNDVYISDR 975
                 67*****************6 PP

  == domain 10  score: 6.9 bits;  conditional E-value: 0.00078
                  BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenhrv 25  
                  f+yP+++   +n+ i+VaD+e+  +
  EFC37228.1 1007 FCYPTSILQ-TNDGILVADTESGLI 1030
                  899999999.7*********98776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       762  (0.042501); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.12u 0.34s 00:00:01.46 Elapsed: 00:00:00.52
# Mc/sec: 13491.27
//
Query:       EFC37229.1  [L=797]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
        2.1    8.7   4.4          1    9.7   0.9    2.3  2  YafQ_toxin  Bacterial toxin of type II toxin-antitoxin system


Domain annotation for each model (and alignments):
>> YafQ_toxin  Bacterial toxin of type II toxin-antitoxin system, YafQ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       0.3   5.4e+03      13      37 ..     325     352 ..     318     362 .. 0.58
   2 ?    9.7   0.9   5.6e-05         1       4      37 ..     567     600 ..     565     610 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.3
                 HHHHH.HTT--HH..HHHHHHHHHHTT- CS
  YafQ_toxin  13 lkrlk.krkkdle..klkevlklLaege 37 
                  k+   k++  +e  ++k+++++L ++e
  EFC37229.1 325 TKKEDrKSRICMEtsEFKNIVEKLTRKE 352
                 4444433333333448888888887776 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 5.6e-05
                 EEEHHHHHHHHHHHHTT--HHHHHHHHHHHHTT- CS
  YafQ_toxin   4 kptkqfkkdlkrlkkrkkdleklkevlklLaege 37 
                 kp k+fkk +kr++ +kk++e l++ + lL + e
  EFC37229.1 567 KPDKKFKKTMKRMEDTKKKAEWLDKYIALLSSPE 600
                 6889*************************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (797 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3353  (0.187015); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                       101  (0.00563333); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.16u 0.33s 00:00:01.49 Elapsed: 00:00:00.52
# Mc/sec: 4654.42
//
Query:       EFC37230.1  [L=615]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-06   26.7   1.4       0.25   12.0   0.1    4.7  5  Ank_2     Ankyrin repeats (3 copies)
      1e-05   25.5   4.9        2.3    9.0   0.3    5.7  6  Ank_3     Ankyrin repeat
     0.0067   16.7   3.3        2.6    8.5   0.1    4.2  4  Ank_5     Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.0   0.1   4.2e-05      0.25      13      63 ..      90     160 ..      81     169 .. 0.69
   2 !    4.7   0.0    0.0079        47      42      82 ..     184     235 ..     175     236 .. 0.73
   3 !    6.1   0.0    0.0028        17       8      44 ..     217     261 ..     210     286 .. 0.71
   4 ?    1.1   0.0       0.1   6.1e+02      14      53 ..     328     364 ..     303     383 .. 0.60
   5 ?    0.0   0.0      0.22   1.3e+03      45      61 ..     415     435 ..     406     459 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.2e-05
       Ank_2  13 vklLlegadpnkngktaLhyAakngnleivklLle........h.................adndgrtpLhyAars 63 
                 v++L     ++ n+ t +h+Aa+++n+ ++ ++l         h                  d++  tpL+yA++ 
  EFC37230.1  90 VNHLQ----FK-NNCTLVHLAARYNNVFVLNWMLTcccddnckHgehslecharqeklwsaCDKNLSTPLFYAIST 160
                 33333....32.679**********888889999755555555255677777776666655558899******965 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0079
       Ank_2  42 vklLleh...........adndgrtpLhyAarsghleivklLlekgadinlk 82 
                 + +Ll++           +d +g+ p+ +A r   + +++lL+  ga++n++
  EFC37230.1 184 IVFLLSQpsvktkqlnhhTDTHGNLPIVVALRRRDYSLADLLILFGAKLNIT 235
                 5566653333344433467789**********9999*******559999975 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0028
       Ank_2   8 gnlelvklLl.egadpn..k.....ngktaLhyAakngnleivkl 44 
                  +++l +lL+ +ga++n        + +++Lh A+++ + +++k+
  EFC37230.1 217 RDYSLADLLIlFGAKLNitVglglgTSESILHSACRERDMKLLKF 261
                 4567899998899998875155677889********986555554 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.1
       Ank_2  14 klLlegadpnk..ngktaLhyAakngnleivklLleh.adndg 53 
                 k L+      k  +g+++L  ++  +++e +k ++++   n+ 
  EFC37230.1 328 KALIL-----KnsFGRNILLESVALNDHESMKVICQFlS-NYQ 364
                 33331.....12388999997777776677777776532.222 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.22
       Ank_2  45 Lleh....adndgrtpLhyAa 61 
                 Lle     +d++g+++Lh+ a
  EFC37230.1 415 LLETivfdTDKQGNSILHIIA 435
                 333233234455555555433 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.3   0.00039       2.3       1      25 [.      97     120 ..      97     123 .. 0.86
   2 ?   -1.1   0.0      0.79   4.7e+03       3      11 ..     151     159 ..     149     163 .. 0.83
   3 !    8.0   0.1   0.00088       5.2       1      31 []     205     234 ..     205     234 .. 0.95
   4 ?    4.0   0.0     0.017     1e+02       3      21 ..     244     262 ..     242     267 .. 0.88
   5 ?    0.0   0.0      0.33     2e+03       2      23 ..     337     361 ..     336     368 .. 0.59
   6 ?   -1.1   0.0      0.79   4.7e+03       2      10 ..     427     435 ..     426     437 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00039
       Ank_3   1 nGetpLhlAarsgnleivkfLlenk 25 
                 n++t+ hlAar++n+ ++ ++l  +
  EFC37230.1  97 NNCTLVHLAARYNNVFVLNWMLT-C 120
                 689************99999987.5 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.79
       Ank_3   3 etpLhlAar 11 
                  tpL++A++
  EFC37230.1 151 STPLFYAIS 159
                 69*****97 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.00088
       Ank_3   1 nGetpLhlAarsgnleivkfLlenkgadvna 31 
                 +G+ p+ +A+r  +++++++L+  +ga +n+
  EFC37230.1 205 HGNLPIVVALRRRDYSLADLLIL-FGAKLNI 234
                 799********************.****996 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.017
       Ank_3   3 etpLhlAarsgnleivkfL 21 
                 e++Lh A+r  + +++kf+
  EFC37230.1 244 ESILHSACRERDMKLLKFI 262
                 799*******999988875 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.33
       Ank_3   2 GetpLhlAarsgnle...ivkfLle 23 
                 G+++L + +  +++e   +++ +l 
  EFC37230.1 337 GRNILLESVALNDHEsmkVICQFLS 361
                 7888886666666654443444444 PP

  == domain 6  score: -1.1 bits;  conditional E-value: 0.79
       Ank_3   2 GetpLhlAa 10 
                 G+++Lh+ a
  EFC37230.1 427 GNSILHIIA 435
                 99****977 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.9   0.4    0.0057        34      13      46 ..      97     126 ..      86     134 .. 0.72
   2 ?   -3.1   0.0       1.9   1.1e+04      12      24 ..     148     158 ..     142     161 .. 0.58
   3 !    8.5   0.1   0.00043       2.6       9      47 ..     199     237 ..     194     243 .. 0.87
   4 ?   -0.3   0.0      0.24   1.4e+03      10      23 ..     421     434 ..     418     438 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0057
       Ank_5  13 dgggntpLhvAakygaadvvrlLlargadlnltd 46 
                 +++  t  h+Aa+y++  v++++l   + ++  +
  EFC37230.1  97 NNC--TLVHLAARYNNVFVLNWML--TCCCDDNC 126
                 333..999***************9..44444444 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.9
       Ank_5  12 ldgggntpLhvAa 24 
                 +  +  tpL +A+
  EFC37230.1 148 K--NLSTPLFYAI 158
                 2..2337777776 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00043
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLlargadlnltds 47 
                 + ++d +gn+p+ vA +++  +++ lL+ +ga ln+t +
  EFC37230.1 199 NHHTDTHGNLPIVVALRRRDYSLADLLILFGAKLNITVG 237
                 4689************************99999988865 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.24
       Ank_5  10 nrldgggntpLhvA 23 
                  ++d+ gn++Lh+ 
  EFC37230.1 421 FDTDKQGNSILHII 434
                 689999******85 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (615 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       871  (0.0485805); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.45
# Mc/sec: 4064.15
//
Query:       EFC37231.1  [L=922]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.4e-28   98.5   0.0      1e-27   97.3   0.0    1.7  1  ABC_tran  ABC transporter
     0.0039   17.0   2.9       0.57    9.9   0.0    2.6  2  AAA_21    AAA domain, putative AbiEii toxin, Type IV TA syste
     0.0089   15.5   0.9     0.0089   15.5   0.9    3.8  4  SieB      Super-infection exclusion protein B
  ------ inclusion threshold ------
       0.01   15.3   0.0      0.043   13.2   0.0    2.1  1  SMC_N     RecF/RecN/SMC N terminal domain
      0.015   16.0   0.2      0.015   16.0   0.2    2.8  3  DUF4162   Domain of unknown function (DUF4162)
        8.6    6.8   9.1       0.58   10.6   2.2    2.4  2  AAA_23    AAA domain


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.3   0.0   3.5e-31     1e-27       1     136 [.     607     750 ..     607     751 .. 0.95

  Alignments for each domain:
  == domain 1  score: 97.3 bits;  conditional E-value: 3.5e-31
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.............HHHTCHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.............xxxxxxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.............esdeeie 86 
                 ++nv++ + +g + +++G+nGaGK+t +++++gl+ p eG  +l gkd+++++ ++l  +ig+++q +++f  + v ++               +++i+
  EFC37231.1 607 VNNVTFCIPRGICFGLLGNNGAGKTTTVNCILGLEFPYEGICTLSGKDINSTDSNILATRIGCVHQFDRFFGIT-VLDQlkffaaikgiprkLIEKHID 704
                 58*****************************************************************8888766.99999*******9999878888** PP

                 HHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  87 kalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpt 136
                 ++l+ +gl+e + +++    + LSgG+++r++la a++ kp+ll+lDE t
  EFC37231.1 705 EILQDVGLTEARRRNC----KDLSGGMQRRLSLAIAMIGKPELLILDEVT 750
                 **********999999....****************************87 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   1.0    0.0037        11       3      23 ..     621     641 ..     619     668 .. 0.78
   2 !    9.9   0.0   0.00019      0.57     236     298 ..     722     782 ..     713     786 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0037
      AAA_21   3 vliGpNgsGKSnLLdaldlla 23 
                 +l G Ng+GK++   ++ +l 
  EFC37231.1 621 GLLGNNGAGKTTTVNCILGLE 641
                 799*********999998884 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00019
      AAA_21 236 elSdGtkrllalltallralkkgsllliDEpEngLHPkllrrllell.kelsrngaQviltTHS 298
                 +lS G++r l l+ a++  +    ll++DE+  gL+P   + +  +l k+ ++++  ++  THS
  EFC37231.1 722 DLSGGMQRRLSLAIAMIGKP---ELLILDEVTGGLDPLSAHGIHMILkKYMEDKNRAILTLTHS 782
                 89******999999998766...9*************888777766654444466666666777 PP

>> SieB  Super-infection exclusion protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.9       0.7   2.1e+03      36      51 ..      89     104 ..      69     115 .. 0.58
   2 ?   -3.0   1.6       1.5   4.5e+03      18      58 ..     350     392 ..     331     396 .. 0.68
   3 ?   -3.9   5.9         3     9e+03       9      51 ..     413     455 ..     409     463 .. 0.61
   4 !   15.5   0.9     3e-06    0.0089      24      74 ..     497     547 ..     475     555 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.7
        SieB  36 glvflisiayllaqvv 51 
                   +++i++++ll+ v 
  EFC37231.1  89 IWILIIVMSILLTFVP 104
                 3445555555555443 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.5
        SieB  18 llekln..lgkfleeyglwiglvflisiayllaqvvskllaei 58 
                 +++  +  + + +e yg++  l +++ ++++  + v++++a i
  EFC37231.1 350 FAQDRSggMMEIIELYGITSTLHAVVKTCFFYGIYVIYVVAQI 392
                 4444335577788888899999999999999998888887665 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 3
        SieB   9 glllllPdsllekln.lgkfleeyglwiglvflis..iayllaqvv 51 
                  +ll+   +++   n ++ f+ + g++ig+ +li+  +    ++v+
  EFC37231.1 413 TALLIWGITIISIANvISVFKVKSGYFIGFCLLIFgfL---GSIVA 455
                 45555555666666656667778999999999886443...33333 PP

  == domain 4  score: 15.5 bits;  conditional E-value: 3e-06
        SieB  24 lgkfleeyglwiglvflisiayllaqvvskllaeikekikkkreqkkvekk 74 
                  ++++  y++ ig+ ++i++a  +a++v+ l++++++ +k k+  ++++k 
  EFC37231.1 497 GEQVVIAYAFLIGVTLIIALAVPVANLVILLFKKLYKLLKAKKLSQETMKL 547
                 5678999***********************************999999886 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   1.5e-05     0.043      94     203 ..     248     785 ..     233     802 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.5e-05
                 SSCEEEEEEEETTSEEEEEETTEEE-H.HHHHHHHHCTT-STT........................................................ CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxx........................................................ RF
       SMC_N  94 keevsisrrvkrkgeseykingkevtk.kevsellesagiske........................................................ 135
                 k +  i+++++++ +s+ ++n +  ++ k+v ++l s  ++                                                          
  EFC37231.1 248 KFNSIINVKKSENVNSNLQLNLEITSYyKQVYNQLISLILKTVieslpdsninpithttlrfnndpstsslmalgttdfiplitlaiipiclsllfpvf 346
                 445555555555555666666555554455555555555554466677777777777777777777777777777777777777777777777777777 PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37231.1 347 idsfaqdrsggmmeiielygitstlhavvktcffygiyviyvvaqivvglafqnpfflknnagiyitalliwgitiisianvisvfkvksgyfigfcll 445
                 777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777 PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37231.1 446 ifgflgsivaifvfsngimpyylllipsiaflrilllmilpsmlvpiegnygeqvviayafligvtliialavpvanlvillfkklykllkakklsqet 544
                 777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777 PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37231.1 545 mklkdnfnknystdavatphdvdkvaddtverevqyvlnntnmennvievrqltkrygskvavnnvtfciprgicfgllgnngagktttvncilglefp 643
                 777777777777777777777777777777777777777777778888888888888888889999999999999999999999999999999999999 PP

                 ..............................................................................CS-HHHHHHHHHHHHHHHHCC CS
                 ..............................................................................xxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 ..............................................................................lLSgGektLvalaLlfAiqkv 156
                                                                                                LSgG +      L +Ai ++
  EFC37231.1 644 yegictlsgkdinstdsnilatrigcvhqfdrffgitvldqlkffaaikgiprkliekhideilqdvgltearrrnckDLSGGMQR----RLSLAIAMI 738
                 999999999999999999999999999999999999999999999999999999999999999999999999***999*****876....555678899 PP

                 S--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHCC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 157 kpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreemle 203
                  +  l +lDe+   LD    + +  +lk+  ++    + +l++ m e
  EFC37231.1 739 GKPELLILDEVTGGLDPLSAHGIHMILKKYMEDKNRAILTLTHSMEE 785
                 9999************************9998888888888877755 PP

>> DUF4162  Domain of unknown function (DUF4162)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       3.6   1.1e+04      25      50 ..     250     275 ..     233     286 .. 0.49
   2 ?   -2.5   0.2         3   8.9e+03      24      54 ..     559     592 ..     538     599 .. 0.61
   3 ?   16.0   0.2     5e-06     0.015       1      81 []     805     911 ..     805     911 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3.6
                 -..---EEEE-TTS-EEEEE------ CS
     DUF4162  25 leepgveeveeeggelelkledeeaa 50 
                 +++ +v++ e+ +++l+l le ++  
  EFC37231.1 250 NSIINVKKSENVNSNLQLNLEITSYY 275
                 22233333333334455555544444 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 3
                 --..--.-EEEE-TT..S-EEEEE---------- CS
     DUF4162  24 lleepg.veeveeeg..gelelkledeeaanell 54 
                 + ++p+ v +v +++  +e++  l++++  n+++
  EFC37231.1 559 AVATPHdVDKVADDTveREVQYVLNNTNMENNVI 592
                 3344555888844444477888888877776666 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 5e-06
                 E-HHHHHTTS.-SSEEEEE...-------..............--.-EEEE-TTS-EEEEE--.-----------.-..---E.......EEEEEEE-- CS
     DUF4162   1 GtleeiKrsy.gknrieve...adaeellee............pg.veeveeeggelelkled.eeaanellkal.t..sgve.......irsFeeeeP 71 
                 Gtl+e+K +y ++ +++v+   ++  e++++            p+ +++ e++ ++le+++ + ++++++ll++l +  +  +       i+  + + +
  EFC37231.1 805 GTLHELKTKYgKGYKLYVQtssTEYNEVARNyvqtslvengipPNlISHNETFANRLEFRIGNhQNDSKQLLETLfKvmT--RkeakhafIVDWTCTMA 901
                 9*********66667779976633333332256667777788777566668888********99*******999874223..234667789999***** PP

                 -HHHHHHHHH CS
     DUF4162  72 sLndIFiekv 81 
                 sL+++Fi+kv
  EFC37231.1 902 SLEEVFIRKV 911
                 ********98 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1         1   3.1e+03     154     175 ..     241     262 ..     171     289 .. 0.53
   2 ?   10.6   2.2    0.0002      0.58      22      39 ..     620     637 ..     608     640 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1
      AAA_23 154 rleelekeleeledekkllekl 175
                 + +e +k+++ + ++kk  + +
  EFC37231.1 241 KYNETIKKFNSIINVKKSENVN 262
                 2222222222222222222211 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.0002
      AAA_23  22 tlItGpNGaGKTTildAi 39 
                 + + G+NGaGKTT +++i
  EFC37231.1 620 FGLLGNNGAGKTTTVNCI 637
                 6789*************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (922 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1231  (0.0686597); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.84u 0.35s 00:00:01.19 Elapsed: 00:00:00.49
# Mc/sec: 5649.03
//
Query:       EFC37232.1  [L=273]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.067   13.1   1.2       0.24   11.3   1.2    1.9  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.2   1.3e-05      0.24       6      38 ..      73     123 ..      73     130 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.3e-05
  F-box-like   6 dEiLlqIFsyLppsd..................LlrlalVCrrWrrvaldt 38 
                 ++iL +IFsyL+ +                   L+ l   C ++r+v +  
  EFC37232.1  73 NDILWEIFSYLSIERielldsidskvlvsnlsaLAKLGSACQQFRNVMNES 123
                 68********8766344777888999999988899999*******998654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (273 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       648  (0.0361426); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1683.42
//
Query:       EFC37233.1  [L=564]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.9e-07   29.4   0.1    1.4e-06   27.9   0.1    1.7  1  Pkinase         Protein kinase domain
     0.0002   20.3   0.0    0.00028   19.8   0.0    1.2  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.025   13.8   0.0      0.046   13.0   0.0    1.5  1  Pkinase_Tyr     Protein tyrosine kinase
      0.053   13.3   0.0       0.12   12.1   0.0    1.7  1  Thrombin_light  Thrombin light chain
       0.13   12.2   0.0       0.19   11.6   0.0    1.2  1  APH             Phosphotransferase enzyme family
       0.13   11.8   8.4      0.088   12.4   5.1    2.5  2  Choline_kinase  Choline/ethanolamine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   0.1   4.7e-10   1.4e-06      83     149 ..     461     523 ..     430     532 .. 0.88

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 4.7e-10
                 EBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESS CS
     Pkinase  83 geladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakele 149
                 +++a+l e   +++e ++ +++  +l  l yl + +++H D+KpeNi +  +++  ++DF +ak+++
  EFC37233.1 461 KSMAKLFE---KMNEINVMDFFIDMLVQLCYLQEGNFVHNDIKPENIVLY-DNHWFLIDFEIAKRYS 523
                 55566665...488999999999**************************9.9************987 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.0   9.3e-08   0.00028     303     371 ..     470     531 ..     354     551 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 9.3e-08
  Pkinase_fungal 303 espkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesga 371
                      +  +++  ++D +  +  L  +++++H+Di  +Ni+++      +++++LiD+++ak +sd + +sg+
      EFC37233.1 470 MNEINVMDFFIDMLVQLCYLQ-EGNFVHNDIKPENIVLY------DNHWFLIDFEIAKRYSDFDINSGK 531
                     445567888999999999999.*****************......89*************987776654 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   1.6e-05     0.046      98     153 ..     468     522 ..     332     537 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.6e-05
                  TTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEET CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi 153
                  ek++  ++++f +++   + yL++ ++vH d+   N++l +n+   + Df +a++ 
   EFC37233.1 468 EKMNEINVMDFFIDMLVQLCYLQEGNFVHNDIKPENIVLYDNHWF-LIDFEIAKRY 522
                  56666777888888888899*******************977765.4588888876 PP

>> Thrombin_light  Thrombin light chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   4.1e-05      0.12      13      47 ..      94     128 ..      80     129 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.1e-05
                     HHSSSGTTTT--TTTGGGT---TTHHHHHHHHHCT CS
  Thrombin_light  13 tFGeGEadCGlRPLFEkkskkDktEkeLLeSYieg 47 
                      FG   ++C + PLFE+k+ + ++   LL SY+++
      EFC37233.1  94 GFGITLNNCQTNPLFEEKKETIENILSLLLSYLQS 128
                     46777799************************985 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   6.4e-05      0.19     163     196 ..     489     519 ..     445     523 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.4e-05
                 SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 163 elptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                  ++  ++H+D++p N+++  d++ +  +iDfe a
  EFC37233.1 489 LQEGNFVHNDIKPENIVLY-DNHWF--LIDFEIA 519
                 466679*************.77777..9***977 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.2   3.7e+03      74     118 ..      64     114 ..      34     137 .. 0.59
   2 ?   12.4   5.1     3e-05     0.088     136     175 ..     485     520 ..     292     529 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.2
                     HHHHHTTCHH.TTSSSS-HHHHHHHHH......HHCCS.TT..ECHHGGCC CS
  Choline_kinase  74 klaelHsleleseskespslwktmqkw......llnkeaqtkakkekkkkq 118
                     +++e+ +l+l+++ + ++   +t+ k+      ++ ++ qt+   e+kk+ 
      EFC37233.1  64 NIKEIENLKLPAHFTFTTKRMETIFKYtlhgfgITLNNCQTNPLFEEKKET 114
                     344555555544455555555555555555555555555555555555544 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 3e-05
                     HHHHCHGG-EEEE-S--SGGGEEE.-CTTEEEE--GTT-E CS
  Choline_kinase 136 klleelespvvfcHnDlqegNillnkeekklvlIDFEYag 175
                     +l+    ++ +f HnD+ ++Ni+l   +++ +lIDFE a 
      EFC37233.1 485 QLC--YLQEGNFVHNDIKPENIVL--YDNHWFLIDFEIAK 520
                     222..233468*************..999********885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (564 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       772  (0.0430587); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.49
# Mc/sec: 3486.30
//
Query:       EFC37234.1  [L=653]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.12   12.8   0.1        1.8    8.9   0.1    2.2  2  NAPRTase_N  Nicotinate phosphoribosyltransferase (NAPRTase) N


Domain annotation for each model (and alignments):
>> NAPRTase_N  Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0     0.024   4.3e+02      44      85 ..     122     163 ..      98     196 .. 0.79
   2 ?    8.9   0.1    0.0001       1.8       6      88 ..     218     300 ..     217     317 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.024
  NAPRTase_N  44 leevieylenlrfteeeieyLkrklpyfkedfleyLrtfrfk 85 
                 l+  ++ + + +++e+ i++L+++ + ++++ ++ L  ++ +
  EFC37234.1 122 LDSNLSSILKEHLDESLINFLQQNPQLIDSSAISLLNLVNKH 163
                 67777888888999********99999**9999999866543 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0001
  NAPRTase_N   6 Ykltmaqavf.kkgp.dvevvfelffRkkpfkgeyaivagleevieylenlrfteeeieyLkrklpyfkedfleyLrtfrfkpse 88 
                 Yk +m      kk+p  v+ +++  +Rkk+ +++ a+v   ++ +e+  +++f+e++ +++  + +  k++fle L+ ++ k+s+
  EFC37234.1 218 YKQHMKPTTKtKKKPkYVPPTMDKAVRKKE-DRLCALVVPNKQSVEFPDEFEFNEKHKSFIY-NPEPTKTSFLERLSFLDSKKSR 300
                 5555555544134446788899999*****.99****************************9.9999*******99988777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (653 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1158  (0.0645881); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.24s 00:00:00.78 Elapsed: 00:00:00.43
# Mc/sec: 4549.68
//
Query:       EFC37235.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      0.002   18.3   0.1     0.0056   16.9   0.1    1.8  1  RNase_H       RNase H
  ------ inclusion threshold ------
        4.4    8.1  11.7         60    4.5  11.7    2.4  1  RecQ_Zn_bind  RecQ zinc-binding


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.1   6.3e-07    0.0056      60     142 ..       4      71 ..       1      72 [. 0.68

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 6.3e-07
                 SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSBHTTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHHH CS
     RNase_H  60 sdekvniytDSkYvvkgitqwvhrwkknawkttseqkpvknkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkeaa 142
                  +++ n+ tDS+ +++ +++  +     + +++  q+     + + ++    k+ +++l +vkgH+    +N  +D+lAke+a
  EFC37235.1   4 NHSNANVHTDSQVAIE-VLKKSY-----RGDFQGFQE-----EFFGTI--KDKHLNIHLVKVKGHEDP--ENIIVDKLAKEGA 71 
                 5778899999999999.554122.....222333332.....344444..234678*********976..9**********98 PP

>> RecQ_Zn_bind  RecQ zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5  11.7    0.0067        60      27      52 ..     177     201 ..     107     214 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0067
  RecQ_Zn_bind  27 kleamlaycentteCrrkllleyFge 52 
                    le+ + yce+t+ C r+++l  F  
    EFC37235.1 177 DLEHFIYYCEETE-CFRRYFLTKFTN 201
                   59999****9999.*********965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       876  (0.0488594); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1827.18
//
Query:       EFC37236.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.7e-75  251.5   0.0    1.2e-74  251.2   0.0    1.0  1  Aldo_ket_red  Aldo/keto reductase family
  ------ inclusion threshold ------
      0.095   12.7   0.0       0.21   11.6   0.0    1.5  1  Ribosomal_L2  Ribosomal Proteins L2, RNA binding domain


Domain annotation for each model (and alignments):
>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  251.2   0.0   1.3e-78   1.2e-74       1     292 [.      28     326 ..      28     327 .. 0.95

  Alignments for each domain:
  == domain 1  score: 251.2 bits;  conditional E-value: 1.3e-78
                   .EEEE-SSS-ST.........TS-HHHHHHHHHHHHHTT--EEE--TT-TTTHHHHHHHHHHHH-TTTGGG-EEEEEE..--SSSTTSSSS-HHHHH CS
  Aldo_ket_red   1 elglGtwqlgsk........eeiskeealellrraleaGinffDtAevYgkgqseellGealkksrkkreeviiatKv..dlrdaeiksglskenir 87 
                   ++ lGt+++g             ++ee  ++  r+l+aG nf+DtA++Y++g+se+l+G+ +kk + +r e++iatK     +++++++g +k+n++
    EFC37236.1  28 PIALGTGHFGHNavfstsmgVGSTDEENEKIFLRYLQAGGNFIDTANLYQDGESEKLIGQLIKKHNIDRNELVIATKYsfSVNQKPNSVGNHKKNLV 124
                   6889999999889999999878889999999***********************************************9999*************** PP

                   HHHHHHHHHHT-S-EEEEEE-S--TTS-.HHHHHHHHHHHHHTTSEEEEEEES--HHHHHHH....HHTTT--EEEEE-B-BTT-HHHHTTHHHHHH CS
  Aldo_ket_red  88 esleeslkrLgtdyvDllllHrpdpslpsieevldaleelvkeGkiraiGvSnfsveqleka....kkkkkvkivavqveynllreleeegllelck 180
                   +s+++sl rL+tdyvD+l++H +d++++    v++al++lvk+Gk+ +i++Sn++++ + +a    + ++  ++v++  +y+l ++  e  ++++++
    EFC37236.1 125 QSVNASLDRLQTDYVDVLYIHYWDYTVD-SHQVIRALDDLVKQGKVLHIAISNTPAWEVARAnsyaEFHALSPFVSYTGNYSLSDRSMELDIIPMAQ 220
                   ****************************.**************************8888888899999***************************** PP

                   HTT-EEEEBSTTGGGTTGTTTSS---SSSCCC-------TS-HHHHHHHHHHHHHHHHTT--HHHHHHHHHTTSTT-SEEEE--SSHHHHHHHHGGG CS
  Aldo_ket_red 181 kkgvpliaysplggGlltgkyqseedkedkeprkdlkrdertsknldaaeelselakehgvslaqlalryalsqpavgivipgasnieqlednldal 277
                   k++++++++s+lggG ltgk q+ ++k    +r++    + t+k +d  + l e+ake g + +q+a++++l++p+v+++++g+s++eqlednl++l
    EFC37236.1 221 KLNIGIVPWSVLGGGKLTGKHQRGQEKS---RRPVV---KFTEKDFDIQDVLLEIAKETGRTASQIAINWVLNKPFVSSTLIGPSTLEQLEDNLKSL 311
                   **********************888875...56665...4499****************************************************** PP

                   G----HHHHHHHHHH CS
  Aldo_ket_red 278 elklseeevaeldel 292
                   e+kl+ee++a+ld++
    EFC37236.1 312 EFKLTEEQIARLDKV 326
                   *************86 PP

>> Ribosomal_L2  Ribosomal Proteins L2, RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   2.3e-05      0.21       6      49 ..     235     278 ..     233     287 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.3e-05
                   --BSSTT--------EE-B--S---SS--EEEEEEE--TT-SS- CS
  Ribosomal_L2   6 gritvrhrggGhkkkyrlidfkrnkekvkgkVveieyDpgRsAp 49 
                   g+ t +h++g  k + ++++f+++  +++ ++ ei +  gR+A 
    EFC37236.1 235 GKLTGKHQRGQEKSRRPVVKFTEKDFDIQDVLLEIAKETGRTAS 278
                   88999*****9999*********9999***************94 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       565  (0.0315132); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.23s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 2354.78
//
Query:       EFC37237.1  [L=264]
Description: electron transferring flavoprotein beta-subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-34  118.5   0.0    4.1e-34  118.1   0.0    1.1  1  ETF       Electron transfer flavoprotein domain


Domain annotation for each model (and alignments):
>> ETF  Electron transfer flavoprotein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.1   0.0   2.3e-38   4.1e-34       4     181 ..      26     217 ..      24     218 .. 0.91

  Alignments for each domain:
  == domain 1  score: 118.1 bits;  conditional E-value: 2.3e-38
                 EE-EC.CCCE-HHHHHHHHHHHHHHHH.HT--EEEEEEES....S-CHHHHHHCT-SEEEEEE-GGGSS-.....-CCHHHHHHHHHHHHC--SEEEEE CS
         ETF   4 laehgvdgklnpvdlealeaArrlkek.aggevtavvvGppeaeealrealaamGadkvilvddpalagy.....daeatakalaalikkedpdlvlag 96 
                 +++++v+ ++np+d  ale++ r+kek +  +++ v++G+++++e lr+ala +G d++i+v+++   g       ++++a +l+ +++++++dlvl+g
  EFC37237.1  26 VVTQQVKHSMNPFDDIALEEGIRIKEKfNSPKLISVSIGTDQCQEILRQALA-KGSDEAIHVKTDFDSGEvqqwiSPLQVAHILRRIVEENQIDLVLLG 123
                 566779*********************544**********************.*********99876666788899*********************** PP

                 SSCC.H..HHHHHHHHHHCT-EEEEEESEEEEETCC...EEEEEECCCCTEEEEEE-TSSSEEEEE-TTSS--.....--S-TT---EEEE--HHH CS
         ETF  97 atai.g..kqvaprlAalLgvplitdvteleveggk...ltvtRpieggnglaevveadlpavltvrpgafep.....aaimaakkkeveevevad 181
                 +++i    +qva+ lA++Lg++++t +++l+   ++     ++R+i+g  gl+    + +p v++++ +++ep     +ai +akkk++++++ +d
  EFC37237.1 124 KQSIdSdnGQVAQLLASMLGTQQATFISKLKPTSEEgkeFEIEREIDG--GLESLMLNGKPSVISCDLRLNEPrfanlKAIIQAKKKPLTTLNYSD 217
                 ****55***********************9875444568*********..**666777********************99**********998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (264 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       735  (0.040995); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1677.58
//
Query:       EFC37238.1  [L=511]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (511 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1096  (0.06113); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 2919.18
//
Query:       EFC37239.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   11.9   0.1       0.22   11.0   0.1    1.5  1  Toxin_10  Insecticidal Crystal Toxin, P42


Domain annotation for each model (and alignments):
>> Toxin_10  Insecticidal Crystal Toxin, P42
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   1.2e-05      0.22     134     160 ..      99     125 ..      53     134 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.2e-05
    Toxin_10 134 lWyreDrytlerldGedvleWevlnpv 160
                 l + +D + l+rl+G +v+ We  n v
  EFC37239.1  99 LIVEKDSFLLDRLNGRKVVYWEKCNFV 125
                 56899*****************98844 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       672  (0.0374812); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.24s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1621.85
//
Query:       EFC37240.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.15   12.2   0.0       0.24   11.5   0.0    1.3  1  MHC_II_beta  Class II histocompatibility antigen, beta domain


Domain annotation for each model (and alignments):
>> MHC_II_beta  Class II histocompatibility antigen, beta domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   1.3e-05      0.24      25      69 ..       2      48 ..       1      51 [. 0.81

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1.3e-05
                 EEEEETTTSSEEESSGGGHHH..HHHHHTSHHHHHHHHTHHHHTHHH CS
  MHC_II_beta 25 lvrfDsdvgefvavtelgrpl..aeywNkqkdllerlraevdtvcrh 69
                 + ++ sd++++va +    pl  +    ++ d+le+ r +++t++++
   EFC37240.1  2 YYHYGSDLAKMVADELSISPLerSTLSHQEFDILEQCRKTIQTFAKK 48
                 789************999776214445566699**********9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 785.99
//
Query:       EFC37241.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.093   12.4   0.0       0.12   12.0   0.0    1.1  1  GSCFA     GSCFA family
        2.9    7.5   9.3       0.11   12.2   2.5    1.8  2  WTF       WTF protein


Domain annotation for each model (and alignments):
>> GSCFA  GSCFA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   1.4e-05      0.12     105     191 ..      30     115 ..      24     124 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.4e-05
       GSCFA 105 lGtaevyrdketgkvvanchklPaerfkkellsveeivedleellerlrevnpklkiilTVSPvrhlkdglvanqlSKatLrlaaee 191
                 lG+   +  +++  v++ +  +P  +  ke l +++ ++ l ++++ l ++   l+++l V    h++d+  +n+ SK +L  a+ +
  EFC37241.1  30 LGLLLFFFPTNEF-VINSFVHTPLFNAMKESLPIHDSLAFLMRFISMLLTIFGGLHLLLMVACNYHQRDVESQNKWSKNVLFNAMVA 115
                 6666666666555.666777788889999****************************************************998765 PP

>> WTF  WTF protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.8      0.14   1.3e+03     182     189 ..      24      31 ..       4      91 .. 0.58
   2 ?   12.2   2.5   1.2e-05      0.11      78     135 ..     106     162 ..      87     165 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.14
         WTF 182 vlifillg 189
                 +++ i+lg
  EFC37241.1  24 IFCEIVLG 31 
                 33333333 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 1.2e-05
         WTF  78 spfllkllisvisisvl..nvtavCvlklkdaifGkveyslvlgifcavcallfilltyf 135
                   +   l+  +++i ++   +  +Cvl+l+ ++  ++ y+l l+i+c+++  +fi++  f
  EFC37241.1 106 KNV---LFNAMVAILLVgdCFHVLCVLTLDGSLKSQIVYQLPLTIYCIIVRGMFIIMNQF 162
                 333...444455555542256789********************************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       855  (0.0476881); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.25s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1062.85
//
Query:       EFC37242.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3717  (0.207318); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                       103  (0.00574488); expected 17.9 (0.001)
Passed Fwd filter:                        35  (0.00195214); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.31u 0.38s 00:00:01.69 Elapsed: 00:00:00.62
# Mc/sec: 2427.13
//
Query:       EFC37243.1  [L=789]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.6e-06   26.2  26.9    3.4e-05   23.5   2.4    5.1  6  DUF4116     Domain of unknown function (DUF4116)
     0.0014   18.4   1.0     0.0046   16.8   0.4    2.2  2  F-box       F-box domain
  ------ inclusion threshold ------
      0.037   13.9   0.1        0.1   12.5   0.1    1.8  1  F-box-like  F-box-like
      0.062   13.6   0.0       0.17   12.2   0.0    1.8  1  TrmE_N      GTP-binding protein TrmE N-terminus
        1.3    9.1   7.5       0.29   11.1   2.7    2.5  2  Mistic      Membrane-integrating protein Mistic
        1.4    9.1   6.1       0.31   11.2   0.1    3.0  3  LPD11       Large polyvalent protein-associated domain 11


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       2.5   7.5e+03      22      31 ..      77      86 ..      77      87 .. 0.89
   2 ?    2.4   0.4     0.043   1.3e+02      16      37 ..     211     232 ..     204     239 .. 0.78
   3 !   23.5   2.4   1.1e-08   3.4e-05       3      45 ..     223     269 ..     221     275 .. 0.86
   4 ?   -3.0   0.1       2.1   6.4e+03       7      22 ..     297     312 ..     296     322 .. 0.82
   5 !   15.3   3.9   4.2e-06     0.013       6      44 ..     526     564 ..     522     568 .. 0.90
   6 ?    0.0   0.6      0.24   7.2e+02      14      32 ..     559     576 ..     552     589 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.5
     DUF4116 22 eLknDkeivl 31
                +L++D ++++
  EFC37243.1 77 KLCQDDWFMI 86
                69******97 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.043
     DUF4116  16 lkylseeLknDkeivlkAvkqn 37 
                 +  ++ eL n k +++k  ++ 
  EFC37243.1 211 FLDIPQELLNCKKFIMKFFEII 232
                 44589************87765 PP

  == domain 3  score: 23.5 bits;  conditional E-value: 1.1e-08
     DUF4116   3 Eivleavkkngs....alkylseeLknDkeivlkAvkqngtalsyas 45 
                  ++++ +++ ++     + +l+e+LknD eiv+ Av +ng  ++++ 
  EFC37243.1 223 KFIMKFFEIIPKacskFFIFLNENLKNDEEIVKLAVSNNGWLIKFVK 269
                 68888888887776668889**********************99985 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 2.1
     DUF4116   7 eavkkngsalkylsee 22 
                 ++++k++ +l +ls++
  EFC37243.1 297 KVFEKYNDSLIHLSDS 312
                 6788999999999987 PP

  == domain 5  score: 15.3 bits;  conditional E-value: 4.2e-06
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 l+ +k +++++  ls+e+kn ke+   A+++ +++l+y+
  EFC37243.1 526 LKMLKYYPNYYSQLSDEFKNEKEFKAIAMENLKCNLKYF 564
                 899*********************999998888999986 PP

  == domain 6  score: 0.0 bits;  conditional E-value: 0.24
     DUF4116  14 salkyls.eeLknDkeivlk 32 
                 ++lky++ e   nD e+v++
  EFC37243.1 559 CNLKYFNvE--NNDDEFVMA 576
                 556665422..379999997 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.9   5.6e+03      12      28 ..       8      26 ..       8      26 .. 0.85
   2 !   16.8   0.4   1.5e-06    0.0046       8      43 ..      80     115 ..      77     117 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.9
                HHHHHTS-HHH..HHHHCT CS
       F-box 12 rhILerLplsd..llalrr 28
                r+IL+ ++  d  +++l++
  EFC37243.1  8 RNILQLVEDDDdqVINLSD 26
                79***99999988888885 PP

  == domain 2  score: 16.8 bits;  conditional E-value: 1.5e-06
                 HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHH CS
       F-box   8 sevlrhILerLplsdllalrrVSkgwrilidsdrlw 43 
                  + +  IL + p+ d + +++V+ ++  l+   r++
  EFC37243.1  80 QDDWFMILDYIPFPDFCKFSLVCSSFAELLTFNRRH 115
                 566889***********************9999887 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   3.5e-05       0.1      11      38 ..      85     110 ..      83     119 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.5e-05
  F-box-like  11 qIFsyLppsdLlrlalVCrrWrrvaldt 38 
                  I++y+p+ d +  +lVC++++++   t
  EFC37243.1  85 MILDYIPFPDFCKFSLVCSSFAELL--T 110
                 69*******************9987..4 PP

>> TrmE_N  GTP-binding protein TrmE N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   5.6e-05      0.17      59      90 ..     631     662 ..     575     675 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.6e-05
                 EEEEEBTTCSTTSSEEEEEEEESSHHHHHHHH CS
      TrmE_N  59 lvlvfkaprsyTgedvvElhlhGgpavvkavl 90 
                 + l+ + ++ +T+ed +E+  hG pa+vk++ 
  EFC37243.1 631 CYLYTDMEHVFTTEDQIEMIDHGTPAIVKKIA 662
                 567888999********************985 PP

>> Mistic  Membrane-integrating protein Mistic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.2       3.4     1e+04      19      35 ..     240     256 ..     237     260 .. 0.80
   2 ?   11.1   2.7   9.8e-05      0.29      14      64 ..     555     606 ..     546     608 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3.4
                 HHHH--SSS-SS-SS-S CS
      Mistic  19 fieLYNeseedkplief 35 
                 fi L  ++++d++++++
  EFC37243.1 240 FIFLNENLKNDEEIVKL 256
                 77788899999999987 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 9.8e-05
                 HHHHHHHHH--.SSS-SS-SS-SHHHHHHHHHHHHHHTSSSS-HHHHHHHHH CS
      Mistic  14 egldafieLYN.eseedkpliefeeevleaiekAkekYGeevvnkKiNtivk 64 
                 e l   ++ +N e ++d+ ++ ++ +  ++i+  k+kYG+e ++++i +i +
  EFC37243.1 555 ENLKCNLKYFNvENNDDEFVMALSGNFKRNIKILKSKYGKENIKERIKRIFQ 606
                 5666677788856677888999*************************99976 PP

>> LPD11  Large polyvalent protein-associated domain 11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1    0.0001      0.31      11      47 ..     160     196 ..     158     200 .. 0.90
   2 ?   -2.6   0.1         2   5.9e+03      40      50 ..     510     520 ..     484     526 .. 0.67
   3 ?   -1.6   0.1      0.96   2.9e+03      23      59 ..     582     619 ..     561     625 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.0001
       LPD11  11 lksDceyylgygnrnekhLwagsveeqieemkelyns 47 
                 l sD+ y+l + +r +++Lw   + ++i+em e++  
  EFC37243.1 160 LFSDMIYFLIEKKRYKQNLWKFIEMDKIREMDERLFI 196
                 669****************************998755 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2
       LPD11  40 emkelynslpe 50 
                 e  +l+n++++
  EFC37243.1 510 ERIKLWNEISK 520
                 34467887776 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.96
       LPD11  23 nrnekhLwagsveeqiee.mkelynslpedeKPewltl 59 
                 +rn k L +   +e i+e +k+++++ +   + ewl +
  EFC37243.1 582 KRNIKILKSKYGKENIKErIKRIFQQENGRIRKEWLNW 619
                 47777888888888886437788877666667777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (789 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1317  (0.0734564); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.79u 0.31s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 4639.26
//
Query:       EFC37244.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-37  127.9   0.9    3.5e-37  126.7   0.3    1.9  2  Sod_Fe_C  Iron/manganese superoxide dismutases, C-terminal do
    5.1e-25   87.8   2.1    9.4e-25   86.9   2.1    1.5  1  Sod_Fe_N  Iron/manganese superoxide dismutases, alpha-hairpin
  ------ inclusion threshold ------
      0.068   13.3   0.0       0.14   12.2   0.0    1.5  1  DUF5617   Domain of unknown function (DUF5617)


Domain annotation for each model (and alignments):
>> Sod_Fe_C  Iron/manganese superoxide dismutases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.55   3.3e+03      78      94 ..      53      69 ..      47      75 .. 0.80
   2 !  126.7   0.3   5.9e-41   3.5e-37       5     101 ..     127     222 ..     124     223 .. 0.97

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.55
                HHTT-HHHHHHHHGGGB CS
    Sod_Fe_C 78 dyqnkradYieafwnvv 94
                +y+++ + Y++++  +v
  EFC37244.1 53 HYNKHHKTYVDKLNALV 69
                57888899999987776 PP

  == domain 2  score: 126.7 bits;  conditional E-value: 5.9e-41
                 HHHHHHHHHSSHHHHHHHHHHHHHHSSSSEEEEEEEETTTEEEEEEEETTTBGGGGTTCEEEEEE-SGGGTHHHHTT-HHHHHHHHGGGBBHHHHHH CS
    Sod_Fe_C   5 laeaieedfgslekfkkefkaaalavfgsGwawLvldkkkkLeivttknqdnplvkeakplLalDvwehAYyldyqnkradYieafwnvvnWkevee 101
                 ++++ie++fgs+++fk++f+++a+++fgsGw+wLvld + +L+i + +n+++p++++  plL++DvwehAYyld+qn+r+dY+++fw+ vnW +v++
  EFC37244.1 127 IKQEIEKQFGSVDAFKQQFTEKATTLFGSGWTWLVLDGT-SLRIWNGSNAQTPIAENLIPLLTCDVWEHAYYLDHQNRRPDYLKTFWEAVNWGFVNK 222
                 6899********************************977.*******************************************************97 PP

>> Sod_Fe_N  Iron/manganese superoxide dismutases, alpha-hairpin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.9   2.1   1.6e-28   9.4e-25       1      81 [.      27     114 ..      27     115 .. 0.94

  Alignments for each domain:
  == domain 1  score: 86.9 bits;  conditional E-value: 1.6e-28
                 S------SS-TTT.TTTTS-HHHHHHHHHTHHHHHHHHHHHHHHCHHHHCHCCHHHHHH......HHHHHHHHHHHHHHHHHHHHHTB CS
    Sod_Fe_N   1 kyeLpeLpYayda.LePhisketlelHhdkHhktYvnnlNkalekleeakkkleelvlk......klekalrnnagghvnHslfwknl 81 
                 k++Lp L+Ya++  + P+i++++l++H++kHhktYv++lN+++e++++++++l+++++k       ++ a++nna++h nHs++wk+l
  EFC37244.1  27 KHQLPTLDYAVEQgIHPVITARQLDFHYNKHHKTYVDKLNALVEGTSFESQPLDAIIQKvaydsdPKSVAIFNNAAQHFNHSFYWKSL 114
                 69********97449******************************************9999998777889****************98 PP

>> DUF5617  Domain of unknown function (DUF5617)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   2.4e-05      0.14      25      67 ..      33      75 ..      15      88 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.4e-05
                HHHHTTSTTT-GGGGGGGGSTTHHHHHHHHHHHHHHHHTT--S CS
     DUF5617 25 ndYtkennllgsllgriftgHWnRHhvkavdkivkeidkgnyt 67
                 dY  e+ ++  +  r + +H+n+Hh   vdk+ + ++ + ++
  EFC37244.1 33 LDYAVEQGIHPVITARQLDFHYNKHHKTYVDKLNALVEGTSFE 75
                48999999999999*****************996555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       464  (0.0258799); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.40u 0.26s 00:00:00.66 Elapsed: 00:00:00.43
# Mc/sec: 1648.45
//
Query:       EFC37245.1  [L=333]
Description: glyceraldehyde-3-phosphate dehydrogenase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-67  226.0   0.1    2.7e-67  225.3   0.1    1.4  1  Gp_dh_C   Glyceraldehyde 3-phosphate dehydrogenase, C-termina
    1.8e-41  140.6   1.1    1.2e-40  137.9   0.2    2.3  2  Gp_dh_N   Glyceraldehyde 3-phosphate dehydrogenase, NAD bindi
  ------ inclusion threshold ------
      0.011   15.9   0.0      0.037   14.1   0.0    2.0  1  DapB_N    Dihydrodipicolinate reductase, N-terminus


Domain annotation for each model (and alignments):
>> Gp_dh_C  Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  225.3   0.1   4.4e-71   2.7e-67       1     158 []     154     312 ..     154     312 .. 1.00

  Alignments for each domain:
  == domain 1  score: 225.3 bits;  conditional E-value: 4.4e-71
                 HHHHHHHHHHHHEEEEEEEEEEEECTTTSBSSSS--.SSTTTTSBTTCSSEEEE-THHHHHHHHSGGGTTTEEEEEEEESSSSEEEEEEEEEESSTS-H CS
     Gp_dh_C   1 LaplakvlndkfgikkglmttvhaytndQkllDgpskkdlrraraaaeniiptstgaakavglVlpelkgkldglAvrVPtpnvsvvdlvvelekevtv 99 
                 Lap+a vl+++fgi++glmttvha+t++Q ++D+ps+kd+r +raa+ niip+stgaakavglV+p+l+gkl+g+A+rVPt++vsvvdl+++lek++t+
  EFC37245.1 154 LAPIAAVLHENFGIVEGLMTTVHAVTATQPTVDAPSRKDWRGGRAAGYNIIPSSTGAAKAVGLVIPSLNGKLTGMAFRVPTVDVSVVDLTCRLEKPATK 252
                 8************************************************************************************************** PP

                 HHHHHHHHHHHH.TTTTTTEEEEHSHHHGGGGTTGCSSEEEEGGGCEEETTTEEEEEEEE CS
     Gp_dh_C 100 eevnaalkeaae.galkgilsyteeelvssDlvgdphssifdaketivveenlvkvvawy 158
                 +++ +a+k+a+e +++kgil++t+ee+vssD+v+d++ss++d+k++i ++e++vkvvawy
  EFC37245.1 253 KQIDEAMKAASEsERFKGILKFTDEEVVSSDFVHDSASSTYDSKASICLNEHFVKVVAWY 312
                 ************999********************************************9 PP

>> Gp_dh_N  Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.9   0.2     2e-44   1.2e-40       1     100 [.       2     102 ..       2     103 .. 0.98
   2 ?    0.7   0.0      0.11   6.7e+02      29      74 ..     270     310 ..     252     330 .. 0.64

  Alignments for each domain:
  == domain 1  score: 137.9 bits;  conditional E-value: 2e-44
                 CEEEEESTSHHHHHHHHHHHHHTTCEEEEEE-.TS-HHHHHHHHHEETTTEC-SS-EEEETTEEEETTEEEEEE--SSGGGS-CHHHTSSEEEE-SSS- CS
     Gp_dh_N   1 vkvainGfGRIGrlvlralleekelevvaind.ltdletlayllkyDsvhgrfkgeveaeeealvvngkkikvlaekdpeelpwkelgvdlVvestGvf 98 
                 vk++inGfGRIGrlv+ra le++++evvaind ++++e++ y++kyD+vhg+f+g++e++e++++vng++i+vl e+dpe+lpw++++v++VvestG+f
  EFC37245.1   2 VKIGINGFGRIGRLVFRASLERTDVEVVAINDiMMTPEYMIYMIKYDTVHGKFHGKLEHTEKSIIVNGREIHVLCERDPEQLPWGQHNVEYVVESTGIF 100
                 69******************************88***************************************************************** PP

                 -S CS
     Gp_dh_N  99 td 100
                 t+
  EFC37245.1 101 TK 102
                 96 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.11
                 EEE-TS-HHHHHHHHHEETTTEC-SS-EEEETTEEEETTEEEEEE- CS
     Gp_dh_N  29 aindltdletlayllkyDsvhgrfkgeveaeeealvvngkkikvla 74 
                  i ++td e +++ + +Ds+  +++++ +     + +n++ +kv+a
  EFC37245.1 270 GILKFTDEEVVSSDFVHDSASSTYDSKAS-----ICLNEHFVKVVA 310
                 56666666666666666666666665544.....566666666555 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   6.2e-06     0.037       1      33 [.       2      33 ..       2      64 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 6.2e-06
                EEEEEETTTSHHHHHHHHHHHHSTTEEEEEEEE CS
      DapB_N  1 ikvavvGasGrmGkevvkaveeaedlelvaavd 33
                +k++++G+ Gr+G+ v +a  e++d+e+va  d
  EFC37245.1  2 VKIGINGF-GRIGRLVFRASLERTDVEVVAIND 33
                69******.********************9755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       598  (0.0333538); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2105.54
//
Query:       EFC37246.1  [L=343]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.4e-72  242.5   0.0    8.2e-72  242.4   0.0    1.0  1  NMO            Nitronate monooxygenase
    1.3e-12   47.4   0.2    3.5e-05   23.0   0.0    2.1  2  IMPDH          IMP dehydrogenase / GMP reductase domain
    4.8e-08   32.5   1.8    6.5e-08   32.0   0.5    1.8  3  DUF561         Protein of unknown function (DUF561)
    2.2e-05   23.8   0.1      3e-05   23.4   0.1    1.2  1  DHO_dh         Dihydroorotate dehydrogenase
    9.5e-05   22.0   0.2    0.00032   20.2   0.2    1.8  1  His_biosynth   Histidine biosynthesis protein
    0.00025   20.2   1.1    0.00042   19.5   0.2    1.7  2  FMN_dh         FMN-dependent dehydrogenase
    0.00035   20.0   0.1    0.00058   19.2   0.1    1.3  1  ThiG           Thiazole biosynthesis protein ThiG
    0.00053   19.2   0.1      0.001   18.3   0.1    1.4  1  NanE           Putative N-acetylmannosamine-6-phosphate epime
     0.0063   15.9   0.8       0.02   14.2   0.8    1.8  1  TMP-TENI       Thiamine monophosphate synthase
     0.0078   15.5   0.2        1.4    8.1   0.2    2.1  2  PEP_hydrolase  Phosphoenolpyruvate hydrolase-like
  ------ inclusion threshold ------
      0.015   14.7   0.1      0.029   13.8   0.1    1.4  1  G3P_antiterm   Glycerol-3-phosphate responsive antiterminator
      0.031   14.1   0.3        1.9    8.4   0.0    3.3  4  IF2_N          Translation initiation factor IF-2, N-terminal
       0.12   11.4   0.1       0.48    9.5   0.0    1.9  2  Dus            Dihydrouridine synthase (Dus)
        5.3    6.7  12.0       0.71    9.5   3.1    3.3  3  VASP_tetra     VASP tetramerisation domain


Domain annotation for each model (and alignments):
>> NMO  Nitronate monooxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  242.4   0.0   6.4e-75   8.2e-72       4     330 ..       4     340 ..       1     341 [. 0.93

  Alignments for each domain:
  == domain 1  score: 242.4 bits;  conditional E-value: 6.4e-75
         NMO   4 ltellkikppvvqpgmggiskarLaaavsnaGgLGvlasgyltaDrlakeirkvkaltdkPfgvnlflpkkdaadra.ekykkeleeaalelnieegvr 101
                 ++ llk+k+p++q++m g  +  La  vs+ G+LG+l  ++l   +++ ei+k+k +td+ f++n f  ++  + +  +++++++e+  +e n+e  + 
  EFC37246.1   4 IKRLLKVKYPIIQAPMAGAQNSTLAIQVSKFGALGSLPCATLDIEEMRREIKKIKLATDHSFNLNFFCHENPNNTKNeNQWRQIIEKYYQEFNVEFKIS 102
                 67899**************************************************************9988777776699*******999999988888 PP

         NMO 102 .......fyrkvevvlde.kvevvsfgfglpteevvarlkeagvvliptissvkearkvearGaDalivqGpeaGGhqG...tpevgd.kglfaLvpqv 188
                        f + +  vl+e k+ vvsf+fglp++e v++lk++++ ++ ++++v+ea  +e+ G D++i+qG eaGGh+G   + ++ +  glf+L+pq+
  EFC37246.1 103 ssisrlpFNENIIPVLNEfKPIVVSFHFGLPSKEIVKELKRMNIRIMSSATTVEEALYLEENGVDIIIAQGIEAGGHRGmflSNDISTqMGLFSLLPQI 201
                 8899***999999888888************************************************************76633444469********* PP

         NMO 189 ldavdiPviAaGGiidrrgvaaaLalGAsgvqigtrfLltkesdakdahkkklleaklddteltsavsGrpaRalatelleeleeakiatlalpeahel 287
                 ++ v++Pv+AaGGi+d++ v aa+ lGAsgvq gt fL ++es++k    kkll      t +t  + GrpaR ++++ ++e+    + + ++p+  + 
  EFC37246.1 202 VKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFLTCQESTVKY---KKLLTDVSLPTAVTNIFTGRPARSIVNRAMKEIGTISEYAPPFPKSTNY 297
                 *******************************************9874...56666667789************************999999******** PP

         NMO 288 akkiraalveagnteegllwagqgidrldkiisvkeLiesLve 330
                   ++r+ l +  n +   lw+gq+    +   + +e++++L++
  EFC37246.1 298 FTPLRNHLERELNFDFSQLWSGQNRTNCKLDSTSHEILQDLIQ 340
                 *****************************************97 PP

>> IMPDH  IMP dehydrogenase / GMP reductase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   2.7e-08   3.5e-05      29     122 ..       6     171 ..       2     188 .. 0.85
   2 !   22.5   0.2   3.8e-08   4.9e-05     201     248 ..     200     247 ..     189     254 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 2.7e-08
                 TTEEESSSEEE-SSTTT-SHHHHHHHHHTTSEEEE-SS.S-HHHHHHHHHHHHTS............................................ CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxx............................................ RF
       IMPDH  29 kkiklniPlvsaamdtvtesemAialareGgigvihkn.lsieeqaeevkkvkrs............................................ 82 
                 + +k++ P++ a+m    +s++Ai++++ G++g +    l+iee  +e+kk+k +                                            
  EFC37246.1   6 RLLKVKYPIIQAPMAGAQNSTLAIQVSKFGALGSLPCAtLDIEEMRREIKKIKLAtdhsfnlnffchenpnntknenqwrqiiekyyqefnvefkisss 104
                 66899*****************************986438*************99999***********999999999999999999999999999999 PP

                 .............................TTSXBXTTSXB-EEEEE-SSTTHHHHHHHHHHTT-SEEEE CS
                 .............................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       IMPDH  83 .............................pnaakdekgrllvgaavgvkedalervkalveagvdvlvv 122
                                              +++  +e +r+ +   +  ++ + e++  l e+gvd+++ 
  EFC37246.1 105 isrlpfneniipvlnefkpivvsfhfglpSKEIVKELKRMNI--RIMSSATTVEEALYLEENGVDIIIA 171
                 999999999999999999999999998864444445555544..4445555788899999999999975 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 3.8e-08
                 HHHCTCT-EEEEES---SHHHHHHHHHTT-SEEEESCCCTTBTTSSSE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       IMPDH 201 eaakkagvpviaDGGikysgdivkAlaaGadavmlGsllagteEspge 248
                 +++kk +vpv+a GGi   + ++ A+ +Ga+ v +G ++  ++Es  +
  EFC37246.1 200 QIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFLTCQESTVK 247
                 568999***************************************876 PP

>> DUF561  Protein of unknown function (DUF561)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       3.3   4.2e+03     186     236 ..      11      60 ..       9      67 .. 0.54
   2 ?   -2.2   0.0       1.5   1.9e+03     143     185 ..      64     105 ..      44     111 .. 0.68
   3 !   32.0   0.5   5.1e-11   6.5e-08     131     220 ..     151     241 ..     144     263 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.3
      DUF561 186 slPvicasGlsdvtvplalslgasGiGigsavsklndeeemvallseikka 236
                 + P+i a       + la++++  G  +gs      d+eem   +++ik a
  EFC37246.1  11 KYPIIQAPMAGAQNSTLAIQVSKFG-ALGSLPCATLDIEEMRREIKKIKLA 60 
                 5566666544444455555544444.2455555555666666666666655 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.5
      DUF561 143 slgvdliqteGkitsiskakkvndliekslstlastyeiskkv 185
                 s ++++   e   ++  ++++ +++iek  + +   ++is+++
  EFC37246.1  64 SFNLNFFCHEN-PNNTKNENQWRQIIEKYYQEFNVEFKISSSI 105
                 55566666665.4455556777888888888888888888877 PP

  == domain 3  score: 32.0 bits;  conditional E-value: 5.1e-11
      DUF561 131 leeqvkLakkLeslgvdliqteGkitsiskakkvndliekslstlastyeiskkvslPvicasGlsd.vtvplalslgasGiGigsavskl 220
                     v+ a  Le+ gvd+i + G  +   +   +++ i + +  ++   +i+kkv++Pv++a G+ d  tv  a++lgasG+  g      
  EFC37246.1 151 SATTVEEALYLEENGVDIIIAQGIEAGGHRGMFLSNDISTQMGLFSLLPQIVKKVKVPVVAAGGIVDaQTVTAAFQLGASGVQCGTVFLTC 241
                 5567788899*************66666678889999***************************9872699***********999865444 PP

>> DHO_dh  Dihydroorotate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.1   2.3e-08     3e-05     111     276 ..      47     238 ..      19     254 .. 0.69

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 2.3e-08
                 HHHHHHHHHHHG.GGESEEEEES-SCTCCTSCCCGCHHHHHHHHHHHHHHHH.................SSEEEEEE-SSSSHHH....HHHHHHHHHH CS
      DHO_dh 111 vddyvevvrkig.pfadilelNvSsPntpglrdlqekeelkaillkvvkevs.................kvpvlvKlaPdltdee....kkdiadvlle 187
                 +++ +  ++ki+    + + lN  + + p     +++++ ++i+ k  +e++                  +pvl    P +  ++     k+i+++l++
  EFC37246.1  47 IEEMRREIKKIKlATDHSFNLNFFCHENPNNT--KNENQWRQIIEKYYQEFNvefkisssisrlpfnenIIPVLNEFKPIVVSFHfglpSKEIVKELKR 143
                 56666666666655555666666666665333..334445555555566655666677777777777766677777777655443222279999***** PP

                 HTECEEEE...BSEE-.-CTTCCGCCCCTT..SSEEEEEGGG.HHHHHHH.....HHHHHHHTTT.S-EEEESS--SHHHHHHHHHHTECEEEESHHH CS
      DHO_dh 188 lkldgiivtNttvqrl.aidlkseknvkan..ktGGlsGkal.kdialkv.....irelykrlkkeipiIgvGGiesgeDalekieaGAslvqvytal 276
                 +++  +  + ttv+    ++ +  + + a+  ++GG  G  l  di++++     + ++ k++k  +p+++ GGi  ++ +   ++ GAs vq +t +
  EFC37246.1 144 MNIRIMS-SATTVEEAlYLEENGVDIIIAQgiEAGGHRGMFLsNDISTQMglfslLPQIVKKVK--VPVVAAGGIVDAQTVTAAFQLGASGVQCGTVF 238
                 ***9998.56666555044444445555557789******994589998653222455555555..9*****************************87 PP

>> His_biosynth  Histidine biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.2   2.5e-07   0.00032     181     225 ..     196     240 ..     123     245 .. 0.74

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 2.5e-07
                   HHHHHHHHHHSSEEEEESS--SHHHHHHHHHTTCSEEEESHHHHT CS
  His_biosynth 181 eltkelaeavkipviasGGvgsledlkelksegvdavivgsalye 225
                   +l+ ++ ++vk+pv+a+GG+ + + + ++++ g+++v +g+++++
    EFC37246.1 196 SLLPQIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFLT 240
                   556677777777777777777777777777777777777777764 PP

>> FMN_dh  FMN-dependent dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.1   1.4e+03      56      70 ..       9      23 ..       9      31 .. 0.81
   2 !   19.5   0.2   3.3e-07   0.00042     226     304 ..     154     239 ..     144     244 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.1
                EESSSEEE--BSTGG CS
      FMN_dh 56 klslPvliaPvglak 70
                k+++P++ aP++ a+
  EFC37246.1  9 KVKYPIIQAPMAGAQ 23
                589********7654 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 3.3e-07
                 SHHHHHHHHHTTESEEEE-..-GGG.......TSSTT---HHHCHHHHHHHH..SS-EEEESS--SHHHHHHHHHTT-SEEEESHHHH CS
      FMN_dh 226 taedakraveaGvdgivvS..NHGG.......RqldgapatidvLpeiveavggrievlvDgGirrGsDvlkAlalGAdavllGRpfl 304
                 t+e+a  + e Gvd+i+      GG         + + +  ++ Lp+iv++v+  ++v++ gGi   + v  A  lGA++v  G  fl
  EFC37246.1 154 TVEEALYLEENGVDIIIAQgiEAGGhrgmflsNDISTQMGLFSLLPQIVKKVK--VPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFL 239
                 566666666777766654322234433344444455555567889*******8..****************************98887 PP

>> ThiG  Thiazole biosynthesis protein ThiG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.1   4.5e-07   0.00058     133     206 ..     167     237 ..     156     252 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 4.5e-07
                 -HHHHHHHHHTT-SEBEEBSSSTTS----S-HHHHHHHHHH-SS-BEEES---SHHHHHHHHHTT-SEEEESHH CS
        ThiG 133 DlvlarrleevGcaavmPlaapiGsglGllnkealkiiieeakvPvivDAGigspsdaaqamelGadavllnta 206
                 D+++a+ + e+G +  m l+  i + +Gl +   l  i++++kvPv+   Gi  ++ +++a++lGa++v   t 
  EFC37246.1 167 DIIIAQGI-EAGGHRGMFLSNDISTQMGLFS--LLPQIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTV 237
                 66666665.6777888999*********985..799********************************988776 PP

>> NanE  Putative N-acetylmannosamine-6-phosphate epimerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.1   7.8e-07     0.001      82     187 ..     135     249 ..     129     254 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 7.8e-07
                 HHHHHHHHHH--EEEEE-SSHHHHHHHHHTT-SEE...E-TTTTSSTTS-......SS--HHHHHHHH.HTT--EEEES---SHHHHHHHHTT--SEEE CS
        NanE  82 eelikkikekyqllmaDistleeglvakklGvdiv...GttlsGytkeeek.....aepDfalvkals.eaglkviaeGrintPekakkaieiGvdavv 171
                 +e++k++k++   +m+   t+ee+l+ ++ Gvdi+   G    G+ +         +   f+l+ +++ + ++ v+a G i   +    a+++G+  v 
  EFC37246.1 135 KEIVKELKRMNIRIMSSATTVEEALYLEENGVDIIiaqGIEAGGHRGMFLSndistQMGLFSLLPQIVkKVKVPVVAAGGIVDAQTVTAAFQLGASGVQ 233
                 789******************************98555444555543322211223666788998776156899************************* PP

                 E-HHHH-HHHHHHHHH CS
        NanE 172 vGsaitrleeiakkfv 187
                  G+     +e + k+ 
  EFC37246.1 234 CGTVFLTCQESTVKYK 249
                 **98777777666665 PP

>> TMP-TENI  Thiamine monophosphate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.8   1.6e-05      0.02      93     175 ..     142     232 ..     132     236 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.6e-05
    TMP-TENI  93 lgpdliiGlSvhsleeaeeaealgadYigvGpifpTdtK.....kda.eplgl.eglkelaealeiPvvaiGGi.tlenvaevleagadgv 175
                    +  i  S+ + eea+ +e++g+d i +  i +   +     +d  + +gl ++l ++++++++Pvva GGi ++++v ++++ ga+gv
  EFC37246.1 142 KRMNIRIMSSATTVEEALYLEENGVDIIIAQGIEAGGHRgmflsNDIsTQMGLfSLLPQIVKKVKVPVVAAGGIvDAQTVTAAFQLGASGV 232
                 5556667777888888888888888877765554444331111123335666625679***************845667778889999998 PP

>> PEP_hydrolase  Phosphoenolpyruvate hydrolase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0     0.007       8.9     191     266 ..      45     123 ..      16     124 .. 0.63
   2 !    8.1   0.2    0.0011       1.4     141     223 ..     137     216 ..     134     235 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.007
  PEP_hydrolase 191 lsleeavelvqeiadaakevnpdvivlvhGGpiaepe..daeyvlertkg..vkGfigassleRlpvekaikettkeFks 266
                    l++ee+ +++++i   a++ + +   ++h  p ++++  + ++++e+  +     f  +ss+ Rlp++++i  + +eFk 
     EFC37246.1  45 LDIEEMRREIKKIK-LATDHSFNLNFFCHENPNNTKNenQWRQIIEKYYQefNVEFKISSSISRLPFNENIIPVLNEFKP 123
                    45566667777664.44455566777777777655541145566655332113468999*******************96 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0011
  PEP_hydrolase 141 likkAheldllttayvfneeearamaeaGadvivahlGlttggsigaktalsleeavelvqeiadaakevnpdvivlvhGGpi 223
                    ++k+ +++++  ++ +++ eea  + e G+d+i+a+ G+ +gg+ g+  ++++++ + l + + + +k+v+    v++ GG +
     EFC37246.1 137 IVKELKRMNIRIMSSATTVEEALYLEENGVDIIIAQ-GIEAGGHRGMFLSNDISTQMGLFSLLPQIVKKVKVP--VVAAGGIV 216
                    677778888888999999**************9986.*********999999999999998888888888644..34455544 PP

>> G3P_antiterm  Glycerol-3-phosphate responsive antiterminator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   2.3e-05     0.029     130     168 ..     197     235 ..     192     239 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.3e-05
                   HHCTSTTS...EEEEESS--SHHHHHHHCTT.SSEEEE- CS
  G3P_antiterm 130 vikeikkelkipiiaGGLietkedveealkaGaiavsts 168
                   ++ +i k++k+p++a+G i + ++v++a++ Ga++v ++
    EFC37246.1 197 LLPQIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCG 235
                   6778999****************************9875 PP

>> IF2_N  Translation initiation factor IF-2, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.28   3.6e+02      19      40 ..      86     106 ..      85     107 .. 0.91
   2 ?    8.4   0.0    0.0015       1.9      14      38 ..     131     154 ..     129     158 .. 0.78
   3 ?   -2.3   0.0       3.2     4e+03      30      47 ..     207     224 ..     200     226 .. 0.75
   4 ?   -1.1   0.0       1.3   1.7e+03      14      30 ..     328     342 ..     326     343 .] 0.77

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.28
       IF2_N  19 evikkLfkelGievkshsssLD 40 
                 ++i+k  +e+ +e  ++sss++
  EFC37246.1  86 QIIEKYYQEFNVE-FKISSSIS 106
                 69***********.*****997 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0015
       IF2_N  14 gvkskevikkLfkelGievkshsss 38 
                 g++ske++k+L k + i   s   +
  EFC37246.1 131 GLPSKEIVKEL-KRMNIRIMSSATT 154
                 89*********.8899986665555 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 3.2
       IF2_N  30 ievkshsssLDeetaeli 47 
                 ++v+ +  ++D++t++++
  EFC37246.1 207 VPVVAAGGIVDAQTVTAA 224
                 677778888999999886 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 1.3
       IF2_N  14 gvkskevikkLfkelGi 30 
                   +s+e+++ L   +Gi
  EFC37246.1 328 DSTSHEILQDL-I-QGI 342
                 56899*****9.6.677 PP

>> Dus  Dihydrouridine synthase (Dus)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.93   1.2e+03       2      23 ..      16      37 ..      15      76 .. 0.78
   2 ?    9.5   0.0   0.00037      0.48     177     213 ..     200     235 ..     186     258 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.93
                E---TTTS-HHHHHHHHHTT-S CS
         Dus  2 laPmagvtdlpfRelvrefgat 23
                 aPmag  ++++   v +fga 
  EFC37246.1 16 QAPMAGAQNSTLAIQVSKFGAL 37
                6999999999999999999875 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00037
                 HHHHH-SS-EEEESS--SHHHHHHHHHHH--SEEEES CS
         Dus 177 evkqavsipviaNGdIkdaedaqaileetGadgvmig 213
                 ++ ++v++pv+a G+I da+ + a+ +  Ga gv +g
  EFC37246.1 200 QIVKKVKVPVVAAGGIVDAQTVTAAFQL-GASGVQCG 235
                 78999********************999.**999887 PP

>> VASP_tetra  VASP tetramerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.42   5.4e+02      19      29 ..       7      17 ..       5      20 .. 0.87
   2 ?    9.5   3.1   0.00055      0.71      12      23 ..      47      58 ..      47      59 .. 0.94
   3 ?   -0.3   0.7      0.63     8e+02      13      21 ..     135     143 ..     135     145 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.42
  VASP_tetra 19 LqKvKeEIIeA 29
                L KvK  II A
  EFC37246.1  7 LLKVKYPIIQA 17
                67*******98 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00055
  VASP_tetra 12 LeEvrkELqKvK 23
                +eE+r+E++K+K
  EFC37246.1 47 IEEMRREIKKIK 58
                69*********9 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.63
  VASP_tetra  13 eEvrkELqK 21 
                 +E++kEL+ 
  EFC37246.1 135 KEIVKELKR 143
                 578888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       664  (0.037035); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.41
# Mc/sec: 2519.58
//
Query:       EFC37247.1  [L=711]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.022   14.8   0.0      0.066   13.2   0.0    1.9  1  SBBP      Beta-propeller repeat
       0.18   12.1   5.2         58    4.4   0.1    5.1  6  Reg_prop  Two component regulator propeller


Domain annotation for each model (and alignments):
>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   7.4e-06     0.066      13      28 ..     197     212 ..     192     213 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 7.4e-06
        SBBP  13 tygngIavDsnGNiYv 28 
                 +y+++Ia D++G+iY+
  EFC37247.1 197 MYPRSIASDDLGFIYI 212
                 79*************9 PP

>> Reg_prop  Two component regulator propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.32   2.9e+03       4      19 ..     109     124 ..     106     127 .. 0.78
   2 ?    4.4   0.1    0.0065        58       7      23 ..     153     169 ..     149     169 .. 0.83
   3 ?   -0.3   0.0      0.23     2e+03       8      21 ..     200     213 ..     196     214 .. 0.86
   4 ?   -0.9   0.0      0.34   3.1e+03       6      22 ..     336     352 ..     333     354 .. 0.84
   5 ?   -3.2   0.0         2   1.8e+04       1      11 [.     361     371 ..     361     373 .. 0.83
   6 ?    4.1   0.1    0.0084        76      15      23 ..     388     396 ..     378     396 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.32
                 SSCEEEEEE-TTSCEE CS
    Reg_prop   4 snnvtaileDsdGrlW 19 
                 ++n+ ++leD++ r +
  EFC37247.1 109 ASNYASLLEDREKRFY 124
                 566779*****98865 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0065
                 EEEEEE-TTSCEEEEES CS
    Reg_prop   7 vtaileDsdGrlWvGte 23 
                   a+  D  G +W Gt+
  EFC37247.1 153 AMALTMDDYGQIWGGTY 169
                 568999*******9996 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.23
                 EEEEE-TTSCEEEE CS
    Reg_prop   8 taileDsdGrlWvG 21 
                 ++i+ D  G +++G
  EFC37247.1 200 RSIASDDLGFIYIG 213
                 599**********9 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.34
                 CEEEEEE-TTSCEEEEE CS
    Reg_prop   6 nvtaileDsdGrlWvGt 22 
                 n+ +++ ++d +l +G 
  EFC37247.1 336 NIMDMVATPDRNLLIGA 352
                 7889999******9995 PP

  == domain 5  score: -3.2 bits;  conditional E-value: 2
                 SBSSSCEEEEE CS
    Reg_prop   1 glpsnnvtail 11 
                 +l++n+v +++
  EFC37247.1 361 SLNGNPVQSLQ 371
                 6899**99986 PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.0084
                 TSCEEEEES CS
    Reg_prop  15 dGrlWvGte 23 
                 d ++W+Gt+
  EFC37247.1 388 DSNIWIGTY 396
                 569*****7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (711 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      274  (0.0152825); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 4378.71
//
Query:       EFC37248.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-07   30.5   0.1    9.4e-07   28.7   0.0    1.9  2  RWP-RK    RWP-RK domain


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.21   3.8e+03      22      31 ..     182     191 ..     180     192 .. 0.79
   2 !   28.7   0.0   5.3e-11   9.4e-07       2      46 ..     196     244 ..     195     246 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.21
      RWP-RK  22 LgvskttLKr 31 
                 L+   ttLKr
  EFC37248.1 182 LNRRLTTLKR 191
                 666789***8 PP

  == domain 2  score: 28.7 bits;  conditional E-value: 5.3e-11
      RWP-RK   2 ltleelqqyFslplkeAAksLgvskttLKricR....elgIsRWPyRki 46 
                 +++e++ ++ +l+ ++A+ +Lg+s +tLKr+      elg+++WP+  i
  EFC37248.1 196 ISKEDILRVLHLNQQQASSRLGCSVSTLKRRFYalrgELGLTKWPNNYI 244
                 899***************************9988999********8655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1476  (0.0823247); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1661.46
//
Query:       EFC37249.1  [L=577]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.3e-16   57.6  13.0    0.00016   21.3   0.5    6.0  7  DUF4116    Domain of unknown function (DUF4116)
    0.00026   21.4   0.2    0.00085   19.7   0.1    1.9  1  SMI1_KNR4  SMI1 / KNR4 family (SUKH-1)
     0.0019   18.6   0.4       0.02   15.3   0.0    2.5  2  SUKH_6     SMI1-KNR4 cell-wall


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.2   1.2e-07   0.00073       8      49 .]     205     245 ..     202     245 .. 0.93
   2 !   20.3   0.0   5.7e-08   0.00034      15      49 .]     236     270 ..     233     270 .. 0.93
   3 !   18.3   0.2   2.3e-07    0.0014       4      36 ..     250     282 ..     248     293 .. 0.84
   4 !    4.1   0.1    0.0064        38       1      35 [.     272     303 ..     272     314 .. 0.82
   5 ?   -1.9   0.0      0.49   2.9e+03      14      39 ..     340     365 ..     339     371 .. 0.71
   6 !   21.3   0.5   2.7e-08   0.00016      14      49 .]     392     434 ..     352     434 .. 0.85
   7 ?    2.1   0.0     0.028   1.7e+02      19      35 ..     429     445 ..     424     461 .. 0.74

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 1.2e-07
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++k++g+ ++yl e+ knDk ++  A++++++ l +a++++r
  EFC37249.1 205 LLKQYGYLYEYLTESQKNDKKLINLAIQSYPI-LQFAPNSIR 245
                 79**************************9998.999998886 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 5.7e-08
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +l++++++++n k iv  A+k +  ++ ++s+ L+
  EFC37249.1 236 ILQFAPNSIRNEKSIVQLAIKYHTENYTHISDPLK 270
                 79*****************************9775 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 2.3e-07
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 iv  a+k + ++++++s+ Lk+Dk+i+++ +++
  EFC37249.1 250 IVQLAIKYHTENYTHISDPLKKDKDILKQFIER 282
                 66789*************************995 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.0064
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 D++i ++ +++   +l  +++eL  + +++l+ +k
  EFC37249.1 272 DKDILKQFIER--GSLSSIPSELI-NNDLILESLK 303
                 89999999999..55999**9998.7777777777 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 0.49
     DUF4116  14 salkylseeLknDkeivlkAvkqngt 39 
                 + l+ ls+e k    ++++++++++ 
  EFC37249.1 340 NFLTQLSKESKLSEKVLKQIIESDPA 365
                 56677777777777788888888875 PP

  == domain 6  score: 21.3 bits;  conditional E-value: 2.7e-08
     DUF4116  14 s.......alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +        +++l+++L++Dkei+ kAv +n ++++ ++e L+
  EFC37249.1 392 YdnshsimLFTNLPKDLQSDKEIAEKAVLSNFDIYPTLDETLK 434
                 444555558999*************************999986 PP

  == domain 7  score: 2.1 bits;  conditional E-value: 0.028
     DUF4116  19 lseeLknDkeivlkAvk 35 
                 l+e Lk+D+ + l+ + 
  EFC37249.1 429 LDETLKKDRPFNLQLLT 445
                 7899*******999887 PP

>> SMI1_KNR4  SMI1 / KNR4 family (SUKH-1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.1   1.4e-07   0.00085       3      57 ..      70     129 ..      68     240 .. 0.82

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 1.4e-07
                 -HHHHHHHHHHHTS---HHHHHHHHHHTSEEEEETTSEEETTEEEEEE-T.....HHHHS CS
   SMI1_KNR4   3 teedlqefekdlgikLPndyreflkltnGgelfgesnglifglkllslde.....ieeer 57 
                  ee ++ +e ++g+kLP  +ref+k+tnG ++  +++   +  +l++  +      +++r
  EFC37249.1  70 PEEVIEMVECKIGYKLPFHLREFIKITNGRRINLQEEMDENSKDLMGSHWswlnaFQDWR 129
                 6888999**********************9999999888888888888887666566666 PP

>> SUKH_6  SMI1-KNR4 cell-wall
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   3.3e-06      0.02       1      49 [.      71     119 ..      71     136 .. 0.88
   2 ?    0.4   0.1      0.14   8.5e+02      17      37 ..     200     220 ..     191     273 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 3.3e-06
      SUKH_6   1 eeeiaeaEkelgvkLPedYkeflkeynggefggnefigsseesivndal 49 
                 ee i+ +E ++g+kLP  ++ef+k +ng +++ +e + ++ ++   +++
  EFC37249.1  71 EEVIEMVECKIGYKLPFHLREFIKITNGRRINLQEEMDENSKDLMGSHW 119
                 688***************************9999999888888776665 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.14
      SUKH_6  17 edYkeflkeynggefggnefi 37 
                 +d++++lk+y+  + + +e  
  EFC37249.1 200 KDLRTLLKQYGYLYEYLTESQ 220
                 7999******99986555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (577 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       632  (0.0352502); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.26s 00:00:00.95 Elapsed: 00:00:00.47
# Mc/sec: 3692.30
//
Query:       EFC37250.1  [L=272]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.084   12.3   0.1       0.11   11.8   0.1    1.2  1  ATS       acidic terminal segments, variant surface antigen o


Domain annotation for each model (and alignments):
>> ATS  acidic terminal segments, variant surface antigen of PfEMP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   6.3e-06      0.11     276     354 ..      51     129 ..      18     158 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 6.3e-06
         ATS 276 tnsvakktnsdpilnqldlfhkWldrhrdmceklknkeelldklkee.Weket.nsgdihpsddipssnkvlntdvsiqid 354
                 t++  k+     ++ q++lf   l+  r++c++l+  + ++ + +ee  ++e+ +++  ++s++++  +k+l +d s+qi 
  EFC37250.1  51 TKRQ-KENMLRDVKLQIELFNIHLESGRELCNRLERVHPIIVRPREEdLNEEQtTTQGGKKSSGQNLPRKIL-SDGSVQIG 129
                 3333.3333345899*********************888888877661444443333334444445545554.78888885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       425  (0.0237046); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1712.73
//
Query:       EFC37251.1  [L=274]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.9e-15   55.5   3.4    1.2e-13   51.8   3.4    2.1  1  Hemerythrin  Hemerythrin HHE cation binding domain
      1e-07   31.5   0.0    2.4e-07   30.3   0.0    1.6  1  ScdA_N       Domain of Unknown function (DUF542)


Domain annotation for each model (and alignments):
>> Hemerythrin  Hemerythrin HHE cation binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.8   3.4   1.3e-17   1.2e-13       4     130 ..     105     267 ..     102     268 .. 0.90

  Alignments for each domain:
  == domain 1  score: 51.8 bits;  conditional E-value: 1.3e-17
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC..........................HCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH.........CC CS
  Hemerythrin   4 ealdeeHralrallerlraladaaaevhga..........................lrklaelldelvdeleaHhaaEEellfPlle........drp 67 
                  ++++++H++lr+ +  l++l+ ++ +vh                             +k+ +++++l+ el+ H+ +EE+ +fPl+           p
   EFC37251.1 105 HIIHHHHDYLRENIPVLSQLLLKIYTVHMGkliqqarqssgeneqdvasthpsillMEKMYKIFQSLATELLVHLVKEEKDVFPLIIqydeqqdkSNP 202
                  78999**********9999999988888888999999999999999**************************************************** PP

                  C.HHHHHHHHHHHHHHHHHHHHHHHHCHTCGGSTCHHHHH.....HHHHHHHHHHHHHHHHHHTHHHH CS
  Hemerythrin  68 ggravldvlereHdeirelleelrellkgleepsaaafae.....lleeladllreHiakEesilfpl 130
                    ++ l++l ++Hde+++l++ l+   k+l+   + + +      ll+el++ l  H++ E++ilf +
   EFC37251.1 203 FLKSKLASLMEDHDEAGKLIKLLASMRKELP---DYCKTVentkrLLTELEENLYIHVHLENNILFKR 267
                  ********************99997777777...33333346669*********************86 PP

>> ScdA_N  Domain of Unknown function (DUF542)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   0.0   2.6e-11   2.4e-07       5      41 ..      15      52 ..      13      63 .. 0.84

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 2.6e-11
      ScdA_N  5 vGeivaelpra.akvFrkygIDFCCgGkvsLaeAckek 41
                +G++ a++p+    +++k+gID+CCgG++sL  +++e 
  EFC37251.1 15 LGDLIAKYPKGgPLILNKLGIDYCCGGQRSLISVVQES 52
                6888888887525699****************999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1218  (0.0679346); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1667.16
//
Query:       EFC37252.1  [L=698]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   7.1e-132  441.1  40.8   3.8e-125  418.9  25.4    2.3  3  Cullin        Cullin family
    1.3e-25   89.2   2.0    1.3e-25   89.2   2.0    2.5  2  Cullin_Nedd8  Cullin protein neddylation domain
     0.0086   16.1   2.8      0.009   16.0   1.0    2.0  2  HbrB          HbrB-like


Domain annotation for each model (and alignments):
>> Cullin  Cullin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  418.9  25.4  6.3e-129  3.8e-125       1     515 [.      30     548 ..      30     549 .. 0.92
   2 !   35.5   2.3   7.6e-13   4.6e-09     567     618 .]     547     597 ..     547     597 .. 0.95
   3 ?   -4.1   0.3      0.71   4.2e+03     128     157 ..     632     660 ..     613     684 .. 0.55

  Alignments for each domain:
  == domain 1  score: 418.9 bits;  conditional E-value: 6.3e-129
      Cullin   1 WekleeaiqeilkknvsklsfeelYravynlvlskekkqgekLydklkelieehlkellkellkeesdeelLkalkkeWedhktsmkmirdifmyldr. 98 
                 W+ l++aiq+i++++ s+ls+eelYr++y++vl   +++ge Ly++++ ++ e+++ +l++ lk+  de +Lk++ + We++kt ++++++++myl++ 
  EFC37252.1  30 WTLLKQAIQQIYHNKSSELSYEELYRNTYKIVL---NRHGESLYENVEACMLEQVEFILSSVLKKCPDELFLKTICNVWEEYKTETSVVSSVLMYLNTn 125
                 999******************************...99************************9***********************************5 PP

      Cullin  99 ............vyvkklp.............svydlglelfrdhvf.riklkdrlieallkliekeRegevidrsllksviemlvelgedsedkkvYe 171
                             +                    vyd g+e+f++ v+ +++   ++++ ++++i keR ge +dr llk+v++ml e+       ++Y+
  EFC37252.1 126 yalkqlqqqqsqS-----SgnganqtpvkhtlFVYDNGVEIFKRVVIyQSQSGVKIKNIVIEMIGKERGGEYVDRLLLKKVVRMLCEM-------NCYN 212
                 5555555444440.....04444444444445***************9888899**************99****************99.......8*** PP

      Cullin 172 eeFekafleateefYraeaeellaensvaseYlkkaeerleeEeervekyldsstkkkllevleeelikkhleelleee..lkklledekledLkrlyk 268
                 + +e++fle+++++Y + + +lla++ ++++Ylk ++erl+eE++rv+ yl+ +tk+k+ ++l +e+i+khl+++ e      + l+d+k+++L+r+y+
  EFC37252.1 213 DVLEEPFLETSAQYYLQLSRDLLAQT-SITDYLKLVDERLREEDNRVQYYLSFTTKPKISKILRQEMITKHLDTITESPsgYISFLKDDKISELHRMYN 310
                 ************************86.888************************************************76777888888********** PP

      Cullin 269 llsrv.d.gleeLrkaleeyikeegkaivkdakekektedakkyveklLelkdkfdklvkeafnndkefekaldeafeefvnknkvnsksaellakYiD 365
                 l+    +  l+ ++k  ++yi++ g a v d++  + +  a +++e lLe k+k+d++ +e+f+++++fe+a +e f+ f   ++ +++++e+l++Y+D
  EFC37252.1 311 LFLGNeEeHLSIMIKLYKQYITDVGIAYVMDEE--KLQGSAVTFIEGLLEQKRKYDRITRESFKSNSKFEQAQKEGFSIFSDGTR-QKRVSEYLSLYLD 406
                 **9997469****************88888854..47889**************************************9998775.89*********** PP

      Cullin 366 elLkkglkglseeeleekldkvlvlfryiedKDvFekyYkkhLakRLllgksasddaEksmiskLkeecGseftskLegMfkDiklskdlnkefkeyle 464
                 + ++    g se+ele  ++++++lfr+++dKD+Fe+yYk hL+kRLl +  +  + Ek++i k+k+ecG++ftsk+egMf+D+k+s ++n++++++ +
  EFC37252.1 407 NTIRTL--GDSEQELEPIMEDAMALFRFLRDKDIFENYYKVHLSKRLLSKGHQA-NSEKMFILKMKKECGYSFTSKIEGMFNDMKISAQTNEQYQQHDA 502
                 ****85..678*************************************887766.9****************************************987 PP

      Cullin 465 eekkkkkkvdlsvkVLtagaWpterskesevsvklpeeledlieeFeefYk 515
                   k k++++d++v++Lt+++Wp ++ +    +++lp++l+ ++e+F +fY+
  EFC37252.1 503 -FKLKPERMDFNVNILTHSFWPAYTLN----NIILPADLNLCCESFAKFYN 548
                 .7778899**************98885....5******************7 PP

  == domain 2  score: 35.5 bits;  conditional E-value: 7.6e-13
      Cullin 567 yeeiqeatglpekeLkrtLqsLavakkarvLlkepkskdveptdefsvNaeF 618
                 y++i+e t++pek+Lk+tL  L+++k +++L kepk+k++e++++f +N++F
  EFC37252.1 547 YNHIKELTQIPEKDLKKTLTILCMNK-TKILSKEPKTKNLEDNHKFVLNQDF 597
                 789*******************8888.9*******88*************99 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 0.71
      Cullin 128 lieallkliekeRegevidrsllksvieml 157
                 +iea++  + k+R++    ++l+++v++ l
  EFC37252.1 632 VIEAVIVRVMKARKK-LHHNELMSEVVKQL 660
                 444444444444432.23334444444433 PP

>> Cullin_Nedd8  Cullin protein neddylation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       2.1   1.2e+04      13      22 ..     465     474 ..     465     475 .. 0.82
   2 !   89.2   2.0   2.2e-29   1.3e-25       1      61 [.     628     688 ..     628     690 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.1
  Cullin_Nedd8  13 iMKsrktlsh 22 
                   i+K++k++ +
    EFC37252.1 465 ILKMKKECGY 474
                   89****9865 PP

  == domain 2  score: 89.2 bits;  conditional E-value: 2.2e-29
  Cullin_Nedd8   1 dRklaiqaaIVRiMKsrktlshneLvsevieqlskrftpsiadikkrIesLiekeYleRde 61 
                   +Rk +i+a+IVR+MK+rk+l+hneL+sev++ql++rf p+++++k+rIe+Lie+++l+R+ 
    EFC37252.1 628 ERKPVIEAVIVRVMKARKKLHHNELMSEVVKQLQSRFVPNPQEVKRRIENLIERDFLSREV 688
                   699********************************************************85 PP

>> HbrB  HbrB-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   1.0   1.5e-06     0.009       4     127 ..      27     144 ..      24     184 .. 0.75
   2 ?   -3.4   0.0       1.4   8.5e+03      48      72 ..     543     567 ..     532     578 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 1.5e-06
        HbrB   4 ddaWqllcvrvlplFngedlrvpiEdlnklvelhiqlvierakalsllvedleeL.lstglltLenkLsqleeerllkrLveiWkffytqvlpyleavf 101
                 + +W ll+ ++ +++++++++++ E+l +   + +  ++      ++l e++e + l++  ++L++ L+++++e +lk+++++W+  y++    + +v+
  EFC37252.1  27 STTWTLLKQAIQQIYHNKSSELSYEELYRNTYKIVLNRHG-----ESLYENVEACmLEQVEFILSSVLKKCPDELFLKTICNVWEE-YKTETSVVSSVL 119
                 578**********************998866555554444.....589999998527888899*********************96.7778899***** PP

        HbrB 102 LPLetefklssllaeskekrsaspas 127
                 + L+t+  l++l  ++++++  + a+
  EFC37252.1 120 MYLNTNYALKQLQQQQSQSS-GNGAN 144
                 ********988888877744.22222 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.4
        HbrB  48 lsllvedleeLlstglltLenkLsq 72 
                  +++ ++++eL +     L+++L+ 
  EFC37252.1 543 FAKFYNHIKELTQIPEKDLKKTLTI 567
                 6788999999998888888887766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (698 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1081  (0.0602934); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.47
# Mc/sec: 4495.07
//
Query:       EFC37253.1  [L=546]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.5e-14   52.8   0.0    1.3e-13   51.6   0.0    1.6  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
    9.3e-05   22.2   0.1    0.00031   20.6   0.1    2.0  1  F-box-like      F-box-like
    0.00046   19.4   0.0    0.00046   19.4   0.0    2.2  3  Pox_C4_C10      Poxvirus C4/C10 protein
     0.0014   19.2   0.0     0.0033   18.1   0.0    1.6  1  2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
     0.0018   18.5   0.2       0.02   15.2   0.2    2.7  2  PRANC           PRANC domain
     0.0049   17.3   0.0      0.013   16.0   0.0    1.7  1  2OG-FeII_Oxy    2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
      0.048   13.6   0.2      0.048   13.6   0.2    3.2  4  F-box           F-box domain


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.6   0.0   5.2e-17   1.3e-13       2      91 ..      23     118 ..      22     123 .. 0.91

  Alignments for each domain:
  == domain 1  score: 51.6 bits;  conditional E-value: 5.2e-17
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--EEE.....................---TT-EEEEE-..B-TEEE--B.-S CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekeseeGGelelyekdk...........eavkikpkkgrlvlFesdellpHevlpvtkg 85 
                      +++y+ g+++k H+D   k++++++ ++t+l+yLn  ++++GGe ++y++ +             +++kp  g+lvlF+ d    He++ v+k 
      EFC37253.1  23 RFNKYQIGEYFKIHTDGQFKRNNNERSIYTLLIYLN--DDFKGGETRFYNDPEmmdgnsssyynLVHTVKPSMGKLVLFNQDFA--HEGCSVRK- 112
                     6899*999********9888888899*********8..789*******99999*********999999*************877..******66. PP

                     S-EEEE CS
  2OG-FeII_Oxy_3  86 geRlsl 91 
                     g++++l
      EFC37253.1 113 GTKFIL 118
                     599987 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.1   1.2e-07   0.00031       2      24 ..     205     227 ..     204     251 .. 0.75

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.2e-07
  F-box-like   2 srLPdEiLlqIFsyLppsdLlrl 24 
                  +LPdEiL  IFsyL+ s++++l
  EFC37253.1 205 EQLPDEILAIIFSYLKESEICSL 227
                 68*****************9997 PP

>> Pox_C4_C10  Poxvirus C4/C10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   1.8e-07   0.00046      66     119 ..      18      72 ..      13     125 .. 0.80
   2 ?   -3.4   0.0       1.5   3.9e+03     228     251 ..     282     304 ..     275     307 .. 0.77
   3 ?   -2.0   0.2      0.58   1.5e+03       3      53 ..     453     502 ..     451     511 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 1.8e-07
  Pox_C4_C10  66 venkvtlvkyekgdyfkrtrn.lstklskntveyylvlyLekpeeGGetkiyikp 119
                 v++ + + ky+ g+yfk +++ + +++ ++   y+l++yL+   +GGet++y +p
  EFC37253.1  18 VNEMMRFNKYQIGEYFKIHTDgQFKRNNNERSIYTLLIYLNDDFKGGETRFYNDP 72 
                 77888999*************888888889999******************9655 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.5
  Pox_C4_C10 228 yksFadlcvdkifeekelaelend 251
                 +  F  lc+d+  e  ++++l n+
  EFC37253.1 282 ERLFSPLCIDITSE-MTFFQLFNE 304
                 55688999999988.889998876 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.58
  Pox_C4_C10   3 kikiFaddeFdsikkellellkvvdlndkskqivlenslnkdlveklknli 53 
                  i+ F+  + ++i  e + ll ++ +n+   ++ +  +l kd +  +++++
  EFC37253.1 453 DIHSFSAPKLETISTECIDLLPSIITNETTTHLIIV-NLEKDFLISIQKIL 502
                 689999999999999999999999999988887776.67778777777765 PP

>> 2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   1.3e-06    0.0033       1      78 [.      22     111 ..      22     120 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.3e-06
  2OG-FeII_Oxy_4   1 lsvssYekgdvllnHdDvle....geRrva.yilyleeeWkeddGGaLllsdde....g......dvtksivPkwnqlvlFevkeshsvaeva 78 
                     +++++Y+ g+++  H D       +eR ++ +++yl++++k   GG+ ++++d     g      ++++++ P++++lvlF+    h+  +v 
      EFC37253.1  22 MRFNKYQIGEYFKIHTDGQFkrnnNERSIYtLLIYLNDDFK---GGETRFYNDPemmdGnsssyyNLVHTVKPSMGKLVLFNQDFAHEGCSVR 111
                     6789*************853344456766515668888775...******98752333144444468***************98888877665 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.34   8.6e+02      18      53 ..     125     159 ..     115     163 .. 0.73
   2 !   15.2   0.2   7.6e-06      0.02      18      96 ..     150     228 ..     141     229 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.34
       PRANC  18 llvrlinkkklkklkslkiYgklikkiiksakkryk 53 
                 + v   + ++ +k++++ iY+k i+++++++++ +k
  EFC37253.1 125 FRVDASSCPRDDKFDQSEIYKK-IEQLLRKSREQEK 159
                 55666677888999999***86.6777777777665 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 7.6e-06
       PRANC  18 llvrlinkkklkklk.slkiYgklikkiiksakkrykliekaievlnnicskkslWnlLPiEIkykIleyLndkdLknll 96 
                 ll++  +++k  ++   +k Y+   + +++s k  + l+++  + l+ ++ + +    LP EI   I++yL+  ++++l+
  EFC37253.1 150 LLRKSREQEKNGDVMaASKSYRAAQQFLVESGKTFEYLLNRPQDELKRNTYE-NQFEQLPDEILAIIFSYLKESEICSLI 228
                 555555555555565588999999999**********************999.************************997 PP

>> 2OG-FeII_Oxy  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0     5e-06     0.013       7      98 ..      25     125 ..      19     127 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5e-06
                   EEE.....E-S---------EEEEEESSSEEEEEEE-TT---EE.EE.....TEEEE----TTEEEEEE-HHHHHHTTS-S----EEE----GTGS. CS
  2OG-FeII_Oxy   7 lny.....ypphpdpevilglgahtdaslltillqddvgglevf.kd.....gkwlrvppvdnslivniGdallflsngryksvlHrVlpvneger. 91 
                   + y     ++ h+d   +    + + ++ll++l+ d +gg++ f +d     g++ ++    +++++  G    +l n+   ++ H+++ v++g + 
    EFC37253.1  25 NKYqigeyFKIHTDGQFKRNNNERSIYTLLIYLNDDFKGGETRFyNDpemmdGNSSSYYNLVHTVKPSMGKL--VLFNQ---DFAHEGCSVRKGTKf 116
                   4445555456666655444446778889999999999****8873447888777444444678********6..44455...7**********9978 PP

                   ..EEEEEEE CS
  2OG-FeII_Oxy  92 ..Rvsiayf 98 
                     R+ i yf
    EFC37253.1 117 ilRTEIMYF 125
                   888888777 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.2   1.9e-05     0.048       3      26 ..     204     227 ..     203     229 .. 0.93
   2 ?   -1.7   0.1       1.1   2.8e+03      32      45 ..     269     282 ..     268     284 .. 0.79
   3 ?    0.4   0.1      0.25   6.4e+02      23      33 ..     402     412 ..     391     413 .. 0.75
   4 ?   -3.9   0.1       5.5   1.4e+04      11      20 ..     498     507 ..     497     509 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.9e-05
                 HHHS-HHHHHHHHHTS-HHHHHHH CS
       F-box   3 lsrLPsevlrhILerLplsdllal 26 
                 + +LP+e+l  I+++L  s++++l
  EFC37253.1 204 FEQLPDEILAIIFSYLKESEICSL 227
                 679*******************98 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.1
                 HHHHHHTTHHHHHH CS
       F-box  32 gwrilidsdrlwck 45 
                  w+ +++++r   +
  EFC37253.1 269 DWYYCCNNIRNFTE 282
                 5999**99998765 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.25
                 HHHHCTT-HHH CS
       F-box  23 llalrrVSkgw 33 
                 + a+ +VS+++
  EFC37253.1 402 VPACCFVSRHV 412
                 89******985 PP

  == domain 4  score: -3.9 bits;  conditional E-value: 5.5
                 HHHHHHTS-H CS
       F-box  11 lrhILerLpl 20 
                 + +IL++L  
  EFC37253.1 498 IQKILSNLTI 507
                 6799999965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (546 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       587  (0.0327403); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 3346.69
//
Query:       EFC37254.1  [L=183]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.6e-87  285.1   0.6    2.5e-20   71.9   0.0    4.6  6  DUF4116        Domain of unknown function (DUF4116)
    0.00019   21.4   0.4        6.1    7.0   0.0    4.0  4  DUF1667        Protein of unknown function (DUF1667)
     0.0026   17.4   0.5       0.42   10.4   0.1    3.2  3  zf_C2H2_6      Zinc Finger domain
  ------ inclusion threshold ------
      0.014   15.5   0.0        0.3   11.2   0.0    2.2  2  DUF4853        Domain of unknown function (DUF4853)
      0.018   15.5   2.3        0.9    9.9   0.3    2.1  2  SIMPL          Protein of unknown function (DUF541)
      0.025   15.1   1.0          4    8.0   0.1    2.4  2  CbiG_C         Cobalamin synthesis G C-terminus
       0.75   10.4   2.8         16    6.2   0.8    2.8  2  F420_oxidored  NADP oxidoreductase coenzyme F420-dependent


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0   0.00071       1.8      23      45 ..      10      32 ..       8      33 .. 0.89
   2 !   62.0   0.0   1.3e-20   3.3e-17       3      49 .]      39      85 ..      37      85 .. 0.98
   3 !   71.9   0.0   9.7e-24   2.5e-20       1      47 [.      62     108 ..      62     110 .. 0.98
   4 !   66.8   0.0     4e-22     1e-18       1      49 []      87     135 ..      87     135 .. 0.99
   5 !   58.5   0.0   1.5e-19   3.9e-16       1      48 [.     112     159 ..     112     160 .. 0.99
   6 !   41.4   0.0   3.3e-14   8.4e-11       1      42 [.     137     178 ..     137     181 .. 0.95

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00071
     DUF4116 23 LknDkeivlkAvkqngtalsyas 45
                L n + +vl Av+++ +al ya 
  EFC37254.1 10 LWNYRPFVLLAVQRSVDALGYAT 32
                778899***************96 PP

  == domain 2  score: 62.0 bits;  conditional E-value: 1.3e-20
     DUF4116  3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                Eiv+ av+++g+al+++see+++D+eivl+Avk+ g++l++aseeL+
  EFC37254.1 39 EIVKFAVEHCGYALQFASEEITKDREIVLAAVKSKGCSLEFASEELK 85
                9********************************************97 PP

  == domain 3  score: 71.9 bits;  conditional E-value: 9.7e-24
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 DrEivl avk+ g++l+++seeLk+D+eiv++Avkqng al+ asee
  EFC37254.1  62 DREIVLAAVKSKGCSLEFASEELKSDREIVMEAVKQNGWALENASEE 108
                 9********************************************98 PP

  == domain 4  score: 66.8 bits;  conditional E-value: 4e-22
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+eavk+ng+al+++see +nD+ iv+ Av+q+g++l++as+eL+
  EFC37254.1  87 DREIVMEAVKQNGWALENASEESRNDRKIVMLAVEQYGKVLEFASDELK 135
                 9**********************************************97 PP

  == domain 5  score: 58.5 bits;  conditional E-value: 1.5e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 Dr iv+ av+++g++l+++s+eLknD+eiv+ Avk++  a  yaseeL
  EFC37254.1 112 DRKIVMLAVEQYGKVLEFASDELKNDREIVMTAVKRDYQARMYASEEL 159
                 9*********************************************98 PP

  == domain 6  score: 41.4 bits;  conditional E-value: 3.3e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 DrEiv+ avk++  a  y+seeL  D+e+vl Avkq+g+ ++
  EFC37254.1 137 DREIVMTAVKRDYQARMYASEELAVDREVVLTAVKQSGCYFK 178
                 9*************************************9776 PP

>> DUF1667  Protein of unknown function (DUF1667)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0    0.0024       6.1       5      33 ..      53      81 ..      52      97 .. 0.76
   2 ?    2.6   0.0     0.054   1.4e+02       5      27 ..      78     100 ..      77     115 .. 0.86
   3 !    5.9   0.0    0.0053        14       5      25 ..     128     148 ..     122     153 .. 0.89
   4 ?    3.3   0.0     0.033        86       5      26 ..     153     174 ..     149     180 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0024
     DUF1667  5 eYakkEvtnpkRivtstvkveggelplvp 33
                ++a +E+t+ + iv + vk +g +l+  +
  EFC37254.1 53 QFASEEITKDREIVLAAVKSKGCSLEFAS 81
                69*******************98876654 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.054
     DUF1667   5 eYakkEvtnpkRivtstvkvegg 27 
                 e+a +E+++ + iv+  vk +g 
  EFC37254.1  78 EFASEELKSDREIVMEAVKQNGW 100
                 79*************99998765 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0053
     DUF1667   5 eYakkEvtnpkRivtstvkve 25 
                 e+a +E++n + iv++ vk +
  EFC37254.1 128 EFASDELKNDREIVMTAVKRD 148
                 79****************865 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.033
     DUF1667   5 eYakkEvtnpkRivtstvkveg 26 
                  Ya +E+   + +v + vk +g
  EFC37254.1 153 MYASEELAVDREVVLTAVKQSG 174
                 6*****************9876 PP

>> zf_C2H2_6  Zinc Finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.25   6.5e+02       9      22 ..      51      64 ..      46      66 .. 0.76
   2 !   10.4   0.1   0.00016      0.42       8      23 ..      75      90 ..      73      93 .. 0.92
   3 ?    2.8   0.0     0.039     1e+02      10      22 ..     127     139 ..     126     141 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.25
   zf_C2H2_6  9 sLRFsSpeLKkeHE 22
                 L F S e+ k+ E
  EFC37254.1 51 ALQFASEEITKDRE 64
                48999999998877 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00016
   zf_C2H2_6  8 CsLRFsSpeLKkeHEa 23
                CsL F S eLK + E+
  EFC37254.1 75 CSLEFASEELKSDREI 90
                ************9885 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.039
   zf_C2H2_6  10 LRFsSpeLKkeHE 22 
                 L F S eLK + E
  EFC37254.1 127 LEFASDELKNDRE 139
                 779*******988 PP

>> DUF4853  Domain of unknown function (DUF4853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.037        94      62     112 ..      32      81 ..      22      87 .. 0.85
   2 ?   11.2   0.0   0.00012       0.3      59     111 ..      79     130 ..      74     140 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.037
                 --HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEEEE CS
     DUF4853  62 idfddlrevveeelkplGfkysekpderdkdesrtvvwgderyGgslsvky 112
                 +df++  e+v+ +++  G++++   +e+ kd + ++++  +  G sl++  
  EFC37254.1  32 TDFQKDGEIVKFAVEHCGYALQFASEEITKDREIVLAAVKS-KGCSLEFAS 81 
                 788888899999999999*9999999999*99999977666.799999865 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00012
                 EE---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEEE CS
     DUF4853  59 ipeidfddlrevveeelkplGfkysekpderdkdesrtvvwgderyGgslsvk 111
                 +++ + +  re+v e++k++G ++++  +e+++d + ++++ ++ yG +l++ 
  EFC37254.1  79 FASEELKSDREIVMEAVKQNGWALENASEESRNDRKIVMLAVEQ-YGKVLEFA 130
                 5555556669***************************9999999.*****996 PP

>> SIMPL  Protein of unknown function (DUF541)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.1    0.0071        18       7      51 ..      55      99 ..      40     104 .. 0.81
   2 ?    9.9   0.3   0.00035       0.9       7      54 ..     105     151 ..     102     173 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0071
       SIMPL  7 aevevapDqatltlsvesegkdaaeakaevaekmnavlealkklg 51
                a+ e++ D+ ++   v+s+g +++ a++e++   + v+ea+k++g
  EFC37254.1 55 ASEEITKDREIVLAAVKSKGCSLEFASEELKSDREIVMEAVKQNG 99
                677888888888888888888888888888888888888888655 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00035
       SIMPL   7 aevevapDqatltlsvesegkdaaeakaevaekmnavlealkklgike 54 
                 a+ e  +D+ ++ l ve++gk ++ a++e+++  + v+ a+k+ + ++
  EFC37254.1 105 ASEESRNDRKIVMLAVEQYGKVLEFASDELKNDREIVMTAVKR-DYQA 151
                 889999************************************4.2222 PP

>> CbiG_C  Cobalamin synthesis G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.1    0.0016         4      20      66 ..      56     108 ..      44     116 .. 0.75
   2 ?    5.3   0.1     0.011        28      33      69 ..     125     160 ..     114     174 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0016
                 HHHHHHHCT--GGGEEE......EEESSCCSHHHHHHHHHHHCTSTEEEE-HH CS
      CbiG_C  20 ieealeeaglseeavaa......latidlKadepgllelaeklglplktfsae 66 
                  ee+ ++ ++  +av++      +a+ +lK+d + ++e++++ g+ l+  s+e
  EFC37254.1  56 SEEITKDREIVLAAVKSkgcsleFASEELKSDREIVMEAVKQNGWALENASEE 108
                 45555555555555655556666999999999999999999999999877766 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.011
                 GEEEEEESSCCSHHHHHHHHHHHCTSTEEEE-HHHHH CS
      CbiG_C  33 avaalatidlKadepgllelaeklglplktfsaeeLa 69 
                 +v ++a+ +lK+d + ++ ++++ + + +++++eeLa
  EFC37254.1 125 KVLEFASDELKNDREIVMTAVKR-DYQARMYASEELA 160
                 67889999***999887776665.589********98 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1     0.061   1.6e+02      52      72 ..      53      73 ..      34      97 .. 0.76
   2 ?    6.2   0.8    0.0061        16      32      81 ..     108     157 ..      89     172 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.061
                   CECHHHHHHH-SEEEE-S-HH CS
  F420_oxidored 52 avdneeaaeeadvvvlavkpe 72
                   + + ee  ++ ++v+ avk +
     EFC37254.1 53 QFASEEITKDREIVLAAVKSK 73
                   55789999999******9976 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0061
                    EESSCCCHHHHHHHHC-EEECECHHHHHHH-SEEEE-S-HHHHHHHHHHC CS
  F420_oxidored  32 nsrnpekaeelaeelgvkvtavdneeaaeeadvvvlavkpedveevlsel 81 
                     srn  k+  la e + kv + +  e+ ++ ++v  avk  + + + ++ 
     EFC37254.1 108 ESRNDRKIVMLAVEQYGKVLEFASDELKNDREIVMTAVKRDYQARMYASE 157
                    48999999999955555999989999999999999999988776666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1070.21
//
Query:       EFC37255.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.062   13.1   1.5      0.075   12.8   0.3    1.7  2  SURF6           Surfeit locus protein 6
      0.068   12.3   1.4        0.1   11.7   1.4    1.4  1  TMEM192         TMEM192 family
        3.4    7.6   6.2        3.8    7.5   4.4    1.8  2  DUF4446         Protein of unknown function (DUF4446)


Domain annotation for each model (and alignments):
>> SURF6  Surfeit locus protein 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.29   1.8e+03      63      86 ..     138     161 ..     109     185 .. 0.58
   2 ?   12.8   0.3   1.3e-05     0.075      19     108 ..     184     277 ..     167     296 .. 0.60

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.29
       SURF6  63 dlvFskldfedgaekkskkkkkkk 86 
                   ++++++++++ +++s+++ +k+
  EFC37255.1 138 TTNYQRVNMKNEMQDTSNMHMSKS 161
                 555666666444444444333333 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.3e-05
       SURF6  19 keekeeakkeeeekaeekkakeeaeakkskkkkkkkkeaskkee..dlvFskldfedgaekkskkkkkkk..kkkgptkkdpkqaLkkleakka 108
                  e+k+ +++ ++ k++ ++  +e++++k+k++++++k++s++++   ++Fs+++f++++++++++ + ++   ++g+++  +  a k++ ++ +
  EFC37255.1 184 MENKQLKDEIAQFKRKRDECIRESTPTKRKTSNSNGKTPSSSSTpaCITFSSMAFDESSSSDHSEIDPSQmvVNWGSKTYYLVGAFKAISSRTR 277
                 34555555555556666666666666666666666666653333559********666555554444333455556666666666666666555 PP

>> TMEM192  TMEM192 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   1.4   1.7e-05       0.1     186     234 ..     149     195 ..     101     196 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.7e-05
     TMEM192 186 kllslsqsststevgfrdgssleellekQadlIryLkqhnakLsrrila 234
                 +++  s+ +  +   f+ + +le   e+Q  +I+ L+++n++L++ i +
  EFC37255.1 149 EMQDTSN-MHMSKSQFE-NINLEHRCEQQMLIINQLQMENKQLKDEIAQ 195
                 3322332.334444443.5899999*******************99976 PP

>> DUF4446  Protein of unknown function (DUF4446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   4.4   0.00063       3.8      25      81 ..     148     206 ..     132     219 .. 0.78
   2 ?   -1.4   0.0      0.35   2.1e+03     124     146 ..     285     307 ..     281     309 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00063
     DUF4446  25 kklkkkykklmkgk..dgksleellkekleeveelkeeseelekeieeleeklkkslqk 81 
                 +++++  ++ m+++  ++ +le+  ++++  +++l+ e+++l++ei+++++k ++++++
  EFC37255.1 148 NEMQDTSNMHMSKSqfENINLEHRCEQQMLIINQLQMENKQLKDEIAQFKRKRDECIRE 206
                 345555555555543678899**********************************9986 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.35
     DUF4446 124 tYaKeiekgeseyeLseEEkeal 146
                 ++ Ke  + e++  L++EE + l
  EFC37255.1 285 MFEKEFPEKECKLVLTSEEFKRL 307
                 577999999**********8876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1375  (0.0766914); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 2242.00
//
Query:       EFC37256.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-43  147.3   2.4    2.3e-41  141.6   2.4    2.0  1  DUF4291   Domain of unknown function (DUF4291)


Domain annotation for each model (and alignments):
>> DUF4291  Domain of unknown function (DUF4291)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  141.6   2.4   1.3e-45   2.3e-41       1     162 [.      26     172 ..      26     187 .. 0.89

  Alignments for each domain:
  == domain 1  score: 141.6 bits;  conditional E-value: 1.3e-45
     DUF4291   1 qiralydeetitvYQAykaeiaeaavkaqkfeaspefkteRmtWiKpsflWmlyRsgyatkknQeriLaikikregfeelLekavlssaekeleeekee 99 
                 +i+a+y+e+ + vYQA+++eia++avk+qkf+ +p+++ +RmtW+K ++lWm+yRs+yatk+nQ+riL +++k+++++ +L+ka l+ a +        
  EFC37256.1  26 HIIASYTEDAVLVYQAFNDEIADYAVKHQKFDGCPSYNDTRMTWVKSNWLWMMYRSNYATKQNQTRILGLWLKKSAYDDILKKARLKGAGA-------- 116
                 699********************************************************************************99988443........ PP

     DUF4291 100 wkkelkkskvrvQWdperdlrleklek.rsiqiGlkgelvkkyveewivsiedvtekvrelkkl 162
                           r QWdp+ +++le++++ r +q+G+k++ + +   e  v+i d te ++  kk+
  EFC37256.1 117 -------GLTRAQWDPDYSPELEPIKRrRDLQLGIKKRETFRNG-EDFVEIVDCTELAHISKKT 172
                 .......34689*************97589******98665544.67899******99977765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       521  (0.0290591); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.23s 00:00:00.63 Elapsed: 00:00:00.40
# Mc/sec: 1461.52
//
Query:       EFC37257.1  [L=607]
Description: hypothetical protein NAEGRDRAFT_75016 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.2e-95  312.2  29.9      6e-16   57.9   0.1   11.2 12  DUF4116     Domain of unknown function (DUF4116)
     0.0031   17.7   0.4        7.3    6.9   0.0    3.9  4  GABP-alpha  GA-binding protein alpha chain
     0.0042   17.1   0.1         24    5.1   0.0    4.6  4  DUF1667     Protein of unknown function (DUF1667)
  ------ inclusion threshold ------
      0.028   14.4   0.3       0.78    9.7   0.1    3.1  2  DUF3741     Protein of unknown function (DUF3741)
       0.24   10.4   1.8       0.42    9.6   1.8    1.3  1  DUF1800     Protein of unknown function (DUF1800)
       0.34   10.3   3.8         23    4.3   0.1    3.7  4  DUF3523     Domain of unknown function (DUF3523)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.0    0.0041        12      26      47 ..     126     147 ..      94     149 .. 0.79
   2 !   35.2   0.2   2.4e-12   7.3e-09       1      49 []     151     199 ..     151     199 .. 0.98
   3 !   30.2   0.2   9.3e-11   2.8e-07       1      49 []     176     227 ..     176     227 .. 0.95
   4 !   17.8   0.0   6.8e-07     0.002       1      49 []     201     252 ..     201     252 .. 0.91
   5 !   38.8   0.2   1.9e-13   5.7e-10       1      48 [.     229     276 ..     229     277 .. 0.97
   6 !   41.0   0.7   3.7e-14   1.1e-10       1      49 []     254     308 ..     254     308 .. 0.91
   7 !   50.5   0.0   4.1e-17   1.2e-13       1      49 []     310     358 ..     310     358 .. 0.97
   8 !   45.1   0.0   1.9e-15   5.8e-12       1      44 [.     360     403 ..     360     406 .. 0.96
   9 !   57.9   0.1     2e-19     6e-16       1      49 []     409     456 ..     409     456 .. 0.99
  10 !   46.5   0.2   7.1e-16   2.1e-12       1      49 []     433     489 ..     433     489 .. 0.92
  11 !   34.8   0.1   3.2e-12   9.6e-09       1      31 [.     491     521 ..     491     523 .. 0.97
  12 !    8.1   0.1   0.00073       2.2      22      46 ..     536     561 ..     530     565 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0041
     DUF4116  26 DkeivlkAvkqngtalsyasee 47 
                 + +++ k ++ ngt++++a++e
  EFC37257.1 126 NLQFLDKLLEVNGTFINRAPKE 147
                 6799****************98 PP

  == domain 2  score: 35.2 bits;  conditional E-value: 2.4e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E++ +++k++  a++ l+ eLknDke++l  +++n++  s+++++L+
  EFC37257.1 151 DKEVIRKVMKTYVGAYYMLPQELKNDKELALLSIENNPNLSSFLPNHLK 199
                 9*********************************************997 PP

  == domain 3  score: 30.2 bits;  conditional E-value: 9.3e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk...qngtalsyaseeLr 49 
                 D+E++l  +++n++   +l++ Lk+Dkei +k+++    ng a+  as e+r
  EFC37257.1 176 DKELALLSIENNPNLSSFLPNHLKSDKEIFMKIIQdgcYNGQAFGLASYEIR 227
                 9**********************************88889999999998887 PP

  == domain 4  score: 17.8 bits;  conditional E-value: 6.8e-07
     DUF4116   1 DrEivleavk...kngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Ei +++++    ng a+  +s e+++D+ei l+ v + +++++ a eeL+
  EFC37257.1 201 DKEIFMKIIQdgcYNGQAFGLASYEIRSDREITLQHVAKFPKSIREAAEELQ 252
                 9*********5555566*****************************999996 PP

  == domain 5  score: 38.8 bits;  conditional E-value: 1.9e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrEi l+ v k++++++ + eeL++D++++l+++k ng +++++++++
  EFC37257.1 229 DREITLQHVAKFPKSIREAAEELQSDRDFILQCIKMNGMVIEFIDKKF 276
                 9*******************************************9976 PP

  == domain 6  score: 41.0 bits;  conditional E-value: 3.7e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk......qngtalsyaseeLr 49 
                 Dr+++l+++k ng++++++++++  D+ei+ +Avk      + ++++++a+++++
  EFC37257.1 254 DRDFILQCIKMNGMVIEFIDKKFLFDREIIVEAVKyraspeSKKFPIDFAPNSFK 308
                 9**********************************77777666679999999875 PP

  == domain 7  score: 50.5 bits;  conditional E-value: 4.1e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +rEi+l  v++ g +lk +s ++k+D+eivl+Avkqng al+yas  L+
  EFC37257.1 310 NREIILSSVSHSGASLKSVSIDFKSDREIVLAAVKQNGEALEYASSALK 358
                 8********************************************8775 PP

  == domain 8  score: 45.1 bits;  conditional E-value: 1.9e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 DrEiv  a++k+ s+++++s+ Lk+D+e+v++A+kq+gt l ++
  EFC37257.1 360 DREIVSTAIQKCASSIRFASSGLKKDRELVMQAIKQDGTLLFFF 403
                 9**************************************99885 PP

  == domain 9  score: 57.9 bits;  conditional E-value: 2e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vlea+++ngs l+y+see+  D+eivl+A+++n t+l+yaseeLr
  EFC37257.1 409 DREMVLEALRNNGS-LEYASEEIEADREIVLEAIRINTTNLDYASEELR 456
                 9*************.*********************************8 PP

  == domain 10  score: 46.5 bits;  conditional E-value: 7.1e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt........alsyaseeLr 49 
                 DrEivlea+++n  +l y+seeL++Dkeivl+A+   ++        ++ ya eeL+
  EFC37257.1 433 DREIVLEAIRINTTNLDYASEELRSDKEIVLEAIILESKkeaepfvqPFIYATEELQ 489
                 9********************************997776678888888999999986 PP

  == domain 11  score: 34.8 bits;  conditional E-value: 3.2e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivl 31 
                 D+E+v ++v+++gs+l+++seeL+nD+++++
  EFC37257.1 491 DKEFVIQVVQIDGSSLQFASEELQNDIDVIK 521
                 9****************************97 PP

  == domain 12  score: 8.1 bits;  conditional E-value: 0.00073
     DUF4116  22 eLknDkeivlkAvkqng.talsyase 46 
                 +L++++e+v+++ kqn   ++++++e
  EFC37257.1 536 NLSRNFEFVKQIAKQNFkLVIDFVYE 561
                 7999***********98447777765 PP

>> GABP-alpha  GA-binding protein alpha chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0    0.0024       7.3      39      58 ..     249     268 ..     243     288 .. 0.83
   2 ?   -3.2   0.0       3.3   9.8e+03      42      67 ..     308     335 ..     305     341 .. 0.68
   3 ?    1.4   0.0      0.12   3.6e+02      40      57 ..     381     398 ..     355     403 .. 0.85
   4 ?    4.4   0.0     0.014        42      37      60 ..     484     508 ..     457     531 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0024
  GABP-alpha  39 qkLdedksLvdqcvkgeGlv 58 
                 ++L++d+  + qc+k++G+v
  EFC37257.1 249 EELQSDRDFILQCIKMNGMV 268
                 689***************97 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 3.3
  GABP-alpha  42 dedksLvdqcvkgeGl..vqinvqvkse 67 
                 ++++ ++   v+  G+    +++++ks+
  EFC37257.1 308 KSNREIILSSVSHSGAslKSVSIDFKSD 335
                 5778888888999998533466666664 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.12
  GABP-alpha  40 kLdedksLvdqcvkgeGl 57 
                  L++d+ Lv q +k +G+
  EFC37257.1 381 GLKKDRELVMQAIKQDGT 398
                 5999************98 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.014
  GABP-alpha  37 daqkLdedksLvdqcvkgeGl.vqi 60 
                  +++L++dk  v q v+++G+ +q+
  EFC37257.1 484 ATEELQNDKEFVIQVVQIDGSsLQF 508
                 5789****************97774 PP

>> DUF1667  Protein of unknown function (DUF1667)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.063   1.9e+02       5      37 ..     301     335 ..     300     351 .. 0.81
   2 ?   -0.3   0.0      0.39   1.2e+03       5      24 ..     351     370 ..     345     393 .. 0.84
   3 ?    2.8   0.0     0.041   1.2e+02       5      40 ..     424     461 ..     421     472 .. 0.72
   4 !    5.1   0.0    0.0081        24       6      41 ..     483     518 ..     481     530 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.063
     DUF1667   5 eYakkEvtnpkRivtstvkveggelplvpV..kts 37 
                 ++a + +++ + i+ s+v  +g +l+ v++  k++
  EFC37257.1 301 DFAPNSFKSNREIILSSVSHSGASLKSVSIdfKSD 335
                 689999999****************9999833444 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.39
     DUF1667   5 eYakkEvtnpkRivtstvkv 24 
                 eYa + ++n + iv + ++ 
  EFC37257.1 351 EYASSALKNDREIVSTAIQK 370
                 79999999999999998864 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.041
     DUF1667   5 eYakkEvtnpkRivtstvkveggelplv..pVktsepi 40 
                 eYa +E+++ + iv   ++++  +l     + +++++i
  EFC37257.1 424 EYASEEIEADREIVLEAIRINTTNLDYAseELRSDKEI 461
                 79999999999999999999866644331145555555 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0081
     DUF1667   6 YakkEvtnpkRivtstvkveggelplvpVktsepip 41 
                 Ya +E+ n k  v  +v+++g++l+  +   +++i+
  EFC37257.1 483 YATEELQNDKEFVIQVVQIDGSSLQFASEELQNDID 518
                 *********************999988877766665 PP

>> DUF3741  Protein of unknown function (DUF3741)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1   0.00026      0.78      29      42 ..     198     211 ..     196     212 .. 0.93
   2 ?    0.7   0.0      0.17   5.2e+02      20      38 ..     242     260 ..     239     263 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00026
     DUF3741  29 lssNkdLFlklLqd 42 
                 l s+k+ F+k++qd
  EFC37257.1 198 LKSDKEIFMKIIQD 211
                 89***********9 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.17
     DUF3741  20 KeflDALevlssNkdLFlk 38 
                 K   +A e l+s++d+ l+
  EFC37257.1 242 KSIREAAEELQSDRDFILQ 260
                 667889999*******986 PP

>> DUF1800  Protein of unknown function (DUF1800)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   1.8   0.00014      0.42     128     171 ..      15      55 ..       9      56 .. 0.95

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00014
     DUF1800 128 nFrdLlkavakspaMlvYLdnaqsvkpdpkkkrglNENyARElm 171
                 nF+++  a +++   +++Ldn+ s + +    ++lN Ny RE m
  EFC37257.1  15 NFKKIKSANEENERVILFLDNQASDQFQL---QKLNNNYLREKM 55 
                 899999999********************...9*********87 PP

>> DUF3523  Domain of unknown function (DUF3523)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.2      0.61   1.8e+03      94     152 ..      34      65 ..      10      76 .. 0.48
   2 ?    1.7   0.0     0.046   1.4e+02     188     230 ..     245     287 ..     238     289 .. 0.90
   3 ?    2.4   0.0     0.028        84     186     230 ..     324     368 ..     315     373 .. 0.88
   4 ?    4.3   0.1    0.0075        23     186     229 ..     422     465 ..     409     468 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.61
     DUF3523  94 qeetkqkqqraqyedeLarkryqdeleaqrkrneellkkqeesvlrqEairiqeqrrkt 152
                  +++  + q ++ +++  r+++                            ri ++ rk 
  EFC37257.1  34 DNQASDQFQLQKLNNNYLREKM---------------------------SRISSSTRKY 65 
                 3444444444444444444444...........................4444444443 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.046
     DUF3523 188 eqlrekakeeretvlesiktafsviGgGlralltdkdklvaav 230
                 ++  e+ +++r+ +l+ ik+ + vi+   +++l d++ +v av
  EFC37257.1 245 REAAEELQSDRDFILQCIKMNGMVIEFIDKKFLFDREIIVEAV 287
                 667788999******************999*****99999887 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.028
     DUF3523 186 nleqlrekakeeretvlesiktafsviGgGlralltdkdklvaav 230
                 +l+++  + k++re vl+++k  ++ ++   +al +d++ + +a+
  EFC37257.1 324 SLKSVSIDFKSDREIVLAAVKQNGEALEYASSALKNDREIVSTAI 368
                 56777888999**************************99888877 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.0075
     DUF3523 186 nleqlrekakeeretvlesiktafsviGgGlralltdkdklvaa 229
                 +le   e+++++re vle+i++  + ++   ++l +dk+ ++ a
  EFC37257.1 422 SLEYASEEIEADREIVLEAIRINTTNLDYASEELRSDKEIVLEA 465
                 6788999******************************9977766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (607 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 3813.83
//
Query:       EFC37258.1  [L=722]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-21   75.0  10.6     0.0019   18.1   0.1    6.5  7  NHL             NHL repeat
    2.1e-06   27.8   2.4    2.1e-06   27.8   2.4    3.3  2  zf-B_box        B-box zinc finger
    0.00014   21.2   3.5      0.025   13.7   0.0    2.8  3  DUF5128         6-bladed beta-propeller
     0.0089   16.2   2.5     0.0089   16.2   2.5    3.6  3  FYVE_2          FYVE-type zinc finger
  ------ inclusion threshold ------
      0.022   14.6   3.4      0.037   13.9   3.4    1.3  1  Apolipoprotein  Apolipoprotein A1/A4/E domain
      0.067   12.4   0.0       0.79    8.9   0.0    2.2  2  Lactonase       Lactonase, 7-bladed beta-propeller
       0.16   11.8   3.1       0.22   11.4   2.1    1.7  2  SICA_alpha      SICA extracellular alpha domain
       0.39   10.4   1.3       0.86    9.3   1.2    1.6  1  DUF745          Protein of unknown function (DUF745)
        1.1    9.4   8.4       0.33   11.1   5.2    1.7  2  Fib_alpha       Fibrinogen alpha/beta chain family
        2.2    8.7   5.5        1.2    9.5   2.9    1.8  2  Gp-FAR-1        Nematode fatty acid retinoid binding protein 


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.2   1.1e-06    0.0019       1      26 [.     424     450 ..     424     452 .. 0.94
   2 ?   -2.6   0.0         4   7.1e+03      18      25 ..     489     494 ..     485     496 .. 0.63
   3 ?   -0.8   0.0       1.1     2e+03       1      13 [.     528     540 ..     528     543 .. 0.79
   4 !   14.7   0.1   1.3e-05     0.023      12      27 ..     554     569 ..     549     570 .. 0.87
   5 !   15.0   0.0   1.1e-05     0.019       1      27 [.     593     619 ..     593     620 .. 0.96
   6 !   18.1   0.1   1.1e-06    0.0019       3      26 ..     647     671 ..     645     673 .. 0.94
   7 !   10.3   0.0   0.00032      0.57      11      27 ..     704     720 ..     701     721 .. 0.88

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.1e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvq 26 
                 f  P++v v+ + G i+V+Ds+n+r+q
  EFC37258.1 424 FKGPWDVKVShNCGVIIVSDSRNNRIQ 450
                 678***********************9 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 4
                 EECCCTEE CS
         NHL  18 aDsenhrv 25 
                 +   nh+v
  EFC37258.1 489 C--DNHCV 494
                 4..46665 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 1.1
                 BSSEEEEEEETTT CS
         NHL   1 fnyPhGvavdsnG 13 
                 fn+P+Gv v+++ 
  EFC37258.1 528 FNEPAGVIVCTSR 540
                 99*****988665 PP

  == domain 4  score: 14.7 bits;  conditional E-value: 1.3e-05
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 ++ ++V+D enhrv+v
  EFC37258.1 554 GNTVFVCDGENHRVKV 569
                 799***********98 PP

  == domain 5  score: 15.0 bits;  conditional E-value: 1.1e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 fn+P+G+ ++ n++++V+++++hr+++
  EFC37258.1 593 FNQPEGIYLSINNNLIVSEYGSHRMHI 619
                 9***********************987 PP

  == domain 6  score: 18.1 bits;  conditional E-value: 1.1e-06
                 SEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvq 26 
                 +P+G+a+d +  +++V+D +n+r+ 
  EFC37258.1 647 NPRGIAIDeTLKNVVVCDGGNNRIT 671
                 6**********************96 PP

  == domain 7  score: 10.3 bits;  conditional E-value: 0.00032
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                 ++Gd+y aD+ n+rv++
  EFC37258.1 704 KTGDLYLADYTNSRVVI 720
                 78*************97 PP

>> zf-B_box  B-box zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   4.1      0.12   2.2e+02       5      40 ..      35      78 ..      32      80 .. 0.71
   2 !   27.8   2.4   1.2e-09   2.1e-06       3      38 ..     138     173 ..     136     177 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.12
    zf-B_box  5 kCpeHk.....nkpatlfCedCqqplCeeCstgeHr....gHevv 40
                +C  +k      ++a+  C dC+ +lC+     +Hr     H+v+
  EFC37258.1 35 CCFVCKeevdvFQEAKSQCIDCNLFLCARD-AAIHRkkepSHQVI 78
                566666555544789999*********984.77777666557665 PP

  == domain 2  score: 27.8 bits;  conditional E-value: 1.2e-09
    zf-B_box   3 etkCpeHknkpatlfCedCqqplCeeCstgeHr.gHe 38 
                 ++ C +H+  p++ fC +C++++C+ C  +eHr gH 
  EFC37258.1 138 APLCLIHH-IPINTFCGSCKKLVCSACAIEEHReGHG 173
                 689*****.************************6696 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.3      0.79   1.4e+03     144     204 ..     252     308 ..     198     338 .. 0.52
   2 !    7.4   0.0    0.0012       2.2     106     185 ..     432     518 ..     411     534 .. 0.74
   3 !   13.7   0.0   1.4e-05     0.025      89     135 ..     636     682 ..     628     688 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.79
     DUF5128 144 sdvaqlekdklifdssriedekrskfnlvvtdeegneisgsfpaektldilfnssktfyey 204
                 +d+ ++ +++  +  + i+ +k s  ++ + d++  e+sg+   +++l+ l +    ++++
  EFC37258.1 252 ADIDEICQKQITYTNRVIDLKKISVDYIAEFDKL-AEMSGFEMMDRKLGKLPQT---LQSF 308
                 3333333444444444444444333333333333.4444444444444443332...2222 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0012
     DUF5128 106 idksnesIyildfmknkiltYdLegykfieekkldllv..sdv...aqlekdklifdssrie..dekrskfnlvvtdeegneisgsf 185
                 +  +   I++ d+ +n+i  +dL++ +++ + k +  +   ++   ++ ++d li+ +++    + + ++    ++ e+++ i +s 
  EFC37258.1 432 VSHNCGVIIVSDSRNNRIQFFDLKTKEYKATHKTPKNPryLAIepnFEGNNDALIYTCDNHCvyKYNLKQLLTAHEKEKVEPIWTSG 518
                 55666779999**************************98533377899********8766542222344555555555555555554 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 1.4e-05
     DUF5128  89 gaqGeGPgEYlqindfiidksnesIyildfmknkiltYdLegykfie 135
                 g++G+G  E+++   ++id+  +++ + d  +n+i  ++L+++ f+ 
  EFC37258.1 636 GKEGQGSMEFINPRGIAIDETLKNVVVCDGGNNRITFFNLDSGVFTA 682
                 799***************************************98875 PP

>> FYVE_2  FYVE-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   2.5     5e-06    0.0089      47      91 ..      27      71 ..      13      78 .. 0.80
   2 !    6.2   2.3    0.0066        12      71      92 ..     149     170 ..     140     186 .. 0.85
   3 ?    0.5   2.1      0.38   6.8e+02      16      66 ..     215     264 ..     179     273 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 5e-06
      FYVE_2 47 gnqaklgethCilCleefkllvnskrqCldCklnvCkk.Csvenkk 91
                +  ++++  +C  C ee  ++ + k qC dC+l++C +  +++ kk
  EFC37258.1 27 SA-QQVAPPCCFVCKEEVDVFQEAKSQCIDCNLFLCARdAAIHRKK 71
                44.678889***************************9834444444 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0066
      FYVE_2  71 krqCldCklnvCkkCsvenkke 92 
                 +  C  Ck+ vC +C++e+++e
  EFC37258.1 149 NTFCGSCKKLVCSACAIEEHRE 170
                 578*************997665 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.38
      FYVE_2  16 qrdeklrkkeeeRlgelkeklekekskrellgnqaklgethCilCleefkl 66 
                 + + +l +ke  Rl+e ++ +  + ++++l  +q +l+ +    C ++ ++
  EFC37258.1 215 EEESTLIEKERTRLKEEVQVI-FDGLRQSLQDRQDQLNADIDEICQKQITY 264
                 455667788888888888888.78889999888999988888888877665 PP

>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   3.4     2e-05     0.037      26     102 ..     184     255 ..     175     306 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2e-05
                     HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHCCHHCHCCHCH CS
  Apolipoprotein  26 elrdrlskeleelrarlraeleevrarlepyrdevqeqlgqnleelrqrlapyteelrerlaadaeelqeqlavyae 102
                     e+r++l+k l++lr+ l +e+ee  +   + ++e  + ++++   l+++++ + + lr++l+ + ++l     +  +
      EFC37258.1 184 EERANLEKVLQNLRDSL-KEWEESHKTHDNELEEESTLIEKERTRLKEEVQVIFDGLRQSLQDRQDQLN----ADID 255
                     78899999999999999.666666666666666666666666666666666666666553333333332....2222 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.12   2.2e+02     249     300 ..     430     476 ..     390     527 .. 0.70
   2 ?    8.9   0.0   0.00044      0.79      89     174 ..     599     677 ..     549     688 .. 0.63

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.12
                 EEE-TTSSEEEEEETSSTEEEEEEE-TTT--EEEEEEEE-SSS.--EEEE-T CS
   Lactonase 249 IrlspdgkflyvSnRgadsiavfavdeadgtltlveevstegkfPRdfaldp 300
                 +++s++   + vS+  ++ i  f+++ +     + ++++ + k+PR +a++p
  EFC37258.1 430 VKVSHNCGVIIVSDSRNNRIQFFDLKTK-----EYKATHKTPKNPRYLAIEP 476
                 5555555555555555666666655222.....2222333344555555544 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00044
                 EEEEE-TTSSEEEEEETTTTEEEEEEB.TTSEBESECEEEE.....SSTTT-SSTTEEEEEE-TTSSEEEEEETTTTEEEEEEE.- CS
   Lactonase  89 chlsvdedgkllavAnYsggsvsvfpldadgslkeasqvlkhegsgpnperqesphaHsvvldpdgkfllvpDLGtDrvrvykldk 174
                 ++ls++   + l+v++Y++ +++++ +d+d++   +  v+ +eg+g+ +       +  + +d + k ++v+D G  r+++++ld 
  EFC37258.1 599 IYLSIN---NNLIVSEYGSHRMHIIGIDKDNHEFVSLRVYGKEGQGSME----FINPRGIAIDETLKNVVVCDGGNNRITFFNLDS 677
                 455553...3366777777777777777776666666666666666653....555666777777777777777777777777665 PP

>> SICA_alpha  SICA extracellular alpha domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.6      0.14   2.5e+02      22      51 ..     178     208 ..     166     218 .. 0.74
   2 ?   11.4   2.1   0.00012      0.22       4      60 ..     200     262 ..     197     274 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.14
  SICA_alpha  22 akeitekLkkelekmfeeLkkrLkk.qeske 51 
                  ++i+ + + +lek +++L+++Lk+ +es++
  EFC37258.1 178 ISKIEPEERANLEKVLQNLRDSLKEwEESHK 208
                 55677777899************97565554 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00012
  SICA_alpha   4 lekWlekllkaakatgt....kakeitekLkkelekmfeeLkkrLkk...qeskeiaklCadvk 60 
                 l++W e+++++ ++ ++      ++  ++Lk+e++ +f+ L+++L++   q + +i ++C++  
  EFC37258.1 200 LKEWEESHKTHDNELEEestlI-EKERTRLKEEVQVIFDGLRQSLQDrqdQLNADIDEICQKQI 262
                 7999998877655544467753.444789*****************877778899*****6654 PP

>> DUF745  Protein of unknown function (DUF745)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   1.2   0.00048      0.86     104     150 ..     184     230 ..     168     253 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00048
      DUF745 104 qqlealkallkaakenlenaeqvaagaqqelaektqlleaAkkRvee 150
                 ++ + l+++l++ +++l++ e+  +   +el+e ++l+e+ ++R++e
  EFC37258.1 184 EERANLEKVLQNLRDSLKEWEESHKTHDNELEEESTLIEKERTRLKE 230
                 566789*************************************9854 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   5.2   0.00018      0.33      52     124 ..     187     260 ..     176     270 .. 0.84
   2 ?   -4.1   0.1       9.1   1.6e+04     106     121 ..     330     345 ..     318     353 .. 0.49

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00018
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH.HHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  52 keaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnir.vLqnvlesneqkiqkLeqd 124
                  + e++ ++++dsl+e ++s+k +dn +++ s+ +e+e +rlke+++  +  +r  Lq+  ++++ +i ++ q+
  EFC37258.1 187 ANLEKVLQNLRDSLKEWEESHKTHDNELEEESTLIEKERTRLKEEVQVIFDGLRqSLQDRQDQLNADIDEICQK 260
                 56788999999999999999999999999999999999999999999999666526999999999999887665 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 9.1
                 HHHHHHHHHHHHHHHH CS
   Fib_alpha 106 vLqnvlesneqkiqkL 121
                 +  ++l+  +++i++L
  EFC37258.1 330 NVETMLKYVQREIAQL 345
                 2333333333333333 PP

>> Gp-FAR-1  Nematode fatty acid retinoid binding protein (Gp-FAR-1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   2.9   0.00065       1.2      12     120 ..     175     287 ..     174     315 .. 0.86
   2 ?   -2.5   0.0       3.3     6e+03      55      73 ..     329     347 ..     326     351 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00065
    Gp-FAR-1  12 vealknltdeekaqlkevvknykg.....yknedellaalKkkspaLyekaeklqaklkekvdkLspeakeFvkkliakgrkleaqvlagekpdlselk 105
                 v++++++ +ee+a+l +v +n ++      ++ +   ++l + s  + ++  +l+++++  +d+L++  ++  ++l a++ ++ +++++  +    +lk
  EFC37258.1 175 VNMISKIEPEERANLEKVLQNLRDslkewEESHKTHDNELEEESTLIEKERTRLKEEVQVIFDGLRQSLQDRQDQLNADIDEICQKQITYTNRV-IDLK 272
                 57899****************55556666666666778999999999999******************************99987766544433.369* PP

    Gp-FAR-1 106 kvaktifnkykslse 120
                 k+  ++++++++l e
  EFC37258.1 273 KISVDYIAEFDKLAE 287
                 **********99987 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 3.3
    Gp-FAR-1  55 ekaeklqaklkekvdkLsp 73 
                 +++e++ +++++++++L++
  EFC37258.1 329 TNVETMLKYVQREIAQLGE 347
                 57999**********9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (722 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1495  (0.0833845); expected 358.6 (0.02)
Passed bias filter:                      705  (0.0393218); expected 358.6 (0.02)
Passed Vit filter:                       112  (0.00624686); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.85u 0.33s 00:00:01.18 Elapsed: 00:00:00.48
# Mc/sec: 4495.26
//
Query:       EFC37259.1  [L=245]
Description: hypothetical protein NAEGRDRAFT_59797 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1409  (0.0785878); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1571.38
//
Query:       EFC37260.1  [L=270]
Description: hypothetical protein NAEGRDRAFT_81976 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       704  (0.039266); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:01.31
# Mc/sec: 624.44
//
Query:       EFC37261.1  [L=143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.23   10.8   2.3        1.1    8.6   0.4    2.0  2  TraE      TraE protein


Domain annotation for each model (and alignments):
>> TraE  TraE protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.4     6e-05       1.1       8      55 ..       2      49 ..       1      55 [. 0.85
   2 ?    2.1   0.1    0.0062   1.1e+02      15      38 ..     100     123 ..      90     135 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 6e-05
        TraE  8 srlknllaqnnllalllavllaanlllgslilratrkqrvvlvPpeik 55
                +r+k l+a + + ++l++ +++  ++l  +   ++++  + +vP++ik
  EFC37261.1  2 NRIKSLRALFTFNVALILITTIMMIVLNNINCSSVSELTTLVVPFSIK 49
                6889999999999999977777777777777799999********997 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.0062
        TraE  15 aqnnllalllavllaanlllgsli 38 
                 + +n++a+ ++vl++a ++ ++++
  EFC37261.1 100 FLRNVFAAGMLVLIVACCCCVAVC 123
                 455666655555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1089  (0.0607396); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.34s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 799.23
//
Query:       EFC37262.1  [L=246]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       945  (0.0527079); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1371.98
//
Query:       EFC37263.1  [L=196]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.052   14.3   3.9      0.052   14.3   3.9    2.2  2  DUF4587   Domain of unknown function (DUF4587)


Domain annotation for each model (and alignments):
>> DUF4587  Domain of unknown function (DUF4587)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   3.9   2.9e-06     0.052      42      80 .]      81     116 ..      58     116 .. 0.77
   2 ?   -1.3   0.0      0.21   3.8e+03      70      76 ..     137     143 ..     120     173 .. 0.65

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.9e-06
     DUF4587  42 qpaqkqvllelqqeepeeapvveeaekekppsvhHHHhy 80 
                 +    +++ + +q++p+ ++  ++++++ + +++HHHhy
  EFC37263.1  81 E---DKMSNQYKQSNPKRKKKSVHSSNPSGVTIFHHHHY 116
                 3...5666777889998899999999************9 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.21
     DUF4587  70 kppsvhH 76 
                 ++p +hH
  EFC37263.1 137 ENPFIHH 143
                 4444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1273  (0.0710023); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1118.12
//
Query:       EFC37264.1  [L=2010]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.2e-34  117.5   0.0    9.7e-34  116.4   0.0    1.7  1  bMG10           Bacterial Alpha-2-macroglobulin MG10 domain
    8.4e-17   61.8   0.3    1.4e-15   57.9   0.0    3.2  3  A2M_BRD         Alpha-2-macroglobulin bait region domain
    3.2e-16   58.9   0.0    4.5e-15   55.3   0.0    3.0  2  A2M             Alpha-2-macroglobulin family
      2e-15   57.0   0.0    3.9e-14   52.9   0.0    3.1  3  MG2             MG2 domain
      4e-07   30.7   2.0     0.0003   21.4   0.0    4.3  3  Big_5           Bacterial Ig-like domain
     0.0077   16.4   4.7      0.046   13.9   0.1    4.0  6  MG4             Macroglobulin domain MG4
     0.0094   15.0   2.3      0.075   12.1   0.0    2.5  3  TED_complement  A-macroglobulin TED domain
  ------ inclusion threshold ------
      0.016   15.5   0.0       0.31   11.4   0.0    2.9  2  DUF11           Domain of unknown function DUF11
      0.023   14.7   7.1         17    5.5   0.0    5.9  7  Big_1           Bacterial Ig-like domain (group 1)


Domain annotation for each model (and alignments):
>> bMG10  Bacterial Alpha-2-macroglobulin MG10 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  116.4   0.0   4.9e-37   9.7e-34       1     130 []    1850    1996 ..    1850    1996 .. 0.98

  Alignments for each domain:
  == domain 1  score: 116.4 bits;  conditional E-value: 4.9e-37
       bMG10    1 GlsveReyeklegkevsksda.....klkvGdkvrvrltvttprdleyvaledplPAGlepvnpslgtesesaeeye............wleeltef 80  
                  G++v+R+ye++ ++ + + d      ++k+G++vr++lt+t  +++++val+d lPAGlep+np+l+ + + a+ +             w+ + +++
  EFC37264.1 1850 GFEVQRTYEHVTDSSHVTFDRerntwRFKAGELVRIKLTMTNTSRRYHVALVDFLPAGLEPINPELKGTPDIATVSGsgtnsrsngwwcWWFNPIWY 1946
                  9**************999988999999****************************************99999998889999******999999**** PP

       bMG10   81 syreirddrvvffadylpkgtytfeylvravtpGtfsvppakaeemYaPE 130 
                  ++++ird+rv++f + l +gt++f+y +ra++ G+f +p +kaeemY PE
  EFC37264.1 1947 EHHNIRDERVEAFSSLLWEGTHEFTYIARATSIGSFVIPGVKAEEMYTPE 1996
                  *************************************************9 PP

>> A2M_BRD  Alpha-2-macroglobulin bait region domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.4   2.8e+03      12      88 ..     412     493 ..     406     520 .. 0.57
   2 ?   -1.9   0.0         2   3.9e+03      96     124 ..     836     863 ..     810     880 .. 0.77
   3 !   57.9   0.0     7e-19   1.4e-15       1     140 []    1009    1170 ..    1009    1170 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.4
                 TTSEEEEEEE-SS-EE-TT-....BSS-----.-S...S....-EEEEEE--TT-----EEEEEE..E-..................-CEEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xxxxxxxx RF
     A2M_BRD  12 vGetakltvkstfatverdstlylvlsrgnivssgekveeidsstsfsfpvtadmaPnarvvvyyirrd..................gevvadsv 88 
                 +++t+++tvks     ++     + +++g+iv + +       +++ ++p+      ++++ vy ++++                  g++v dsv
  EFC37264.1 412 PDTTVEFTVKSAR---QS----LQAFKTGVIVLDPTL------NPTPTYPIVTVNLDSVHLSVYQVQPNmysssilhhntystiqypGKLVCDSV 493
                 6677777777744...22....336778888666633......2333333333334444444444343334433333344555555566666665 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 2
                 GGGB-EEEEEEE...-SSSEEEEEEE..E CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
     A2M_BRD  96 fenklsvslesynetrPgeevtlkvkasp 124
                  e+++ +++ + +  +    vt++v+a +
  EFC37264.1 836 GEHQVAIAF-DESDRLVKTPVTISVEATV 863
                 678999999.5555699999999999765 PP

  == domain 3  score: 57.9 bits;  conditional E-value: 7e-19
                  -EEEESSSS--TTSEEEEEEE-SS-EE-TT-........BSS----.-.-S...S....-EEEEEE--TT-----EEEEEE..E-............ CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............ RF
     A2M_BRD    1 lqispdkeeykvGetakltvkstfatverdstl....ylvlsrgni.vssgekveeidsstsfsfpvtadmaPnarvvvyyirrd............ 80  
                  l++ pdk+ey++Ge+ak+ ++s+f+ + +++ l      + s++ i + +g     + +  +f++++t+d +Pn+ v + +  ++            
  EFC37264.1 1009 LTLLPDKTEYQIGEKAKILIQSPFE-TRCEGVLftrlHGIHSQHPIqI-DG-----EPGYIEFELDITSDHIPNIFVSAEV--TGcesrvdaignvl 1096
                  6789********************5.8888833333333455555533.44.....346679***************7777..44556899****** PP

                  ......-CEEEEEEE----.-GGGB-EEEEE.EE...-SSSEEEEEE..E..E.......T-EEEEEEEEHHHHHH CS
                  ......xxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxx..xxxx.......xxxxxxxxxxxxxxxx RF
     A2M_BRD   81 ......gevvadsvqlpvekdfenklsvsle.synetrPgeevtlkv..kasp.......gslvalaaVDksvlll 140 
                        ++++++   ++v  + +++lsv+ + +++  +Pg+e++++v  k +p       g +v+++aVD++vl+l
  EFC37264.1 1097 edlpkqPAFASGECMIKVS-KISRTLSVESKpEREYLTPGSETSIDVivK-DPitgkpleGCEVCIIAVDEAVLSL 1170
                  *******************.89********9647779*****99998442.336666699**************87 PP

>> A2M  Alpha-2-macroglobulin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       1.1   2.1e+03       9      25 ..     706     721 ..     700     735 .. 0.84
   2 !   55.3   0.0   2.2e-18   4.5e-15       2      89 ..    1288    1374 ..    1287    1377 .. 0.96

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.1
                 EC...CEEEEEEEEESS CS
         A2M   9 vtdasgkaslsftlPDs 25 
                 + +++g+ +++f++PD+
  EFC37264.1 706 L-SEDGTFDIQFKVPDN 721
                 3.4789**********7 PP

  == domain 2  score: 55.3 bits;  conditional E-value: 2.2e-18
                  CCEEEEEEC...CEEEEEEEEESSSCEEEEEEEEEETTTEEEEEEEEEEEE--SEEEEEE--SEEETTSEEEEEEEEEE-SSS-EEEE CS
         A2M    2 wlWedvlvtdasgkaslsftlPDsiTtWrvtavalsedkglgvaeplevrvfkpffvdlnlPysvrrgeqveikavvfNyldkeikvr 89  
                  ++++++++t+++g as++f+lPD++T++r+tava++ d  +g+ e+ ++ +  p+ ++++lP+++  g++ e ++v+ N+++  ++v+
  EFC37264.1 1288 AIFSPTNKTNSEGVASVKFKLPDNLTKYRITAVAVKGDWNFGIHES-SMIAQLPLSIRPSLPRFLNFGDRAEFTCVLQNQTQLSLEVH 1374
                  589******999**********************************.*********************************99888875 PP

>> MG2  MG2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.9   0.0   1.9e-17   3.9e-14       3      90 ..     648     741 ..     646     751 .. 0.84
   2 ?   -3.8   0.0         9   1.8e+04       8      33 ..    1129    1155 ..    1128    1164 .. 0.79
   3 ?   -0.6   0.0      0.91   1.8e+03      49      70 ..    1290    1311 ..    1271    1332 .. 0.81

  Alignments for each domain:
  == domain 1  score: 52.9 bits;  conditional E-value: 1.9e-17
                 EEEES-SEE-TT-EEEEEEEEES....TTCSB---.....EEEEEEEE-TTSSEEEEEEEEE-CTTEEEEEEE--TT--SEEEEEEEEECSTTT-EE CS
         MG2   3 fvytDRglYrPgetVslkallrd....etlqglak.....lplkltirdpdgkevkelplatdetggaesefalpeaaklGeysvelsadsaeesls 90 
                  ++ DRglY+P+etVs+k+++r+    ++ +   k     ++ ++t+ d++g+++++  ++ +e+g+++ +f++p++a lG+ s++l+  sa ++ +
  EFC37264.1 648 CMFNDRGLYKPNETVSIKGYVRNfnliDNVE---KieipkTSSTFTVLDARGQKYHSGNVTLSEDGTFDIQFKVPDNANLGSHSISLDGFSAFHQFQ 741
                 6899*******************96664444...3444779**********************************************4444444444 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 9
                  -SEE-TT-EEEEEEEEES.TTCSB--- CS
         MG2    8 RglYrPgetVslkallrd.etlqglak 33  
                  R+ ++Pg + s+ ++++d  t+++l++
  EFC37264.1 1129 REYLTPGSETSIDVIVKDpITGKPLEG 1155
                  77789**********999667777766 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.91
                  EEEEEEE-CTTEEEEEEE--TT CS
         MG2   49 kelplatdetggaesefalpea 70  
                  ++ + +t+++g+a+++f+lp++
  EFC37264.1 1290 FSPTNKTNSEGVASVKFKLPDN 1311
                  5566789999999999999987 PP

>> Big_5  Bacterial Ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.0   1.5e-07    0.0003      24     108 .]     108     193 ..      92     193 .. 0.76
   2 ?    0.7   0.0      0.42   8.4e+02      27     107 ..     350     419 ..     342     420 .. 0.66
   3 ?    4.1   0.2     0.037        75      50      98 ..     824     874 ..     804     879 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 1.5e-07
       Big_5  24 eitvtFseavdastvtaatvialsdsettavtgs........ydasg.ktvtitpsaeLaanttYtvtitagikDlagnalaapytniewsFtT 108
                 ++t+tFs+++ + ++ a++         ++v++s         ++ g kt++   +  ++ +t+Ytvt+++g k   g +l+++ t   +sF T
  EFC37264.1 108 SVTITFSQPMVPVSGVAEVESHN-----IPVEISplpkkggkFKWLGtKTLIYEANYRFDMSTKYTVTVKKGTKSEIGGTLKEDLT---FSFET 193
                 79********9999866644433.....33333333333666446666************************88888755777666...**998 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.42
       Big_5  27 vtFseavdastvtaatvialsdsettavtgsydasgktvtitpsaeLaanttYtvtitagikDlagnalaapytniewsFt 107
                 ++F+ ++d ++ t++ v+ +s     +v+  ++ +    ti  s++ +  ttY v + ++++D+ g+    +  +++++Ft
  EFC37264.1 350 LNFTTNIDLEKLTESMVT-VS----PPVER-MELNPYGCTISVSGKIKGRTTYKVFL-KNLVDVWGQ----ILPDTTVEFT 419
                 677777777777666333.32....22222.23555678899999999999999999.567999987....4444457777 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.037
       Big_5  50 ettavtgsydasg.ktvtitps..aeLaanttYtvtitagikDlagnalaap 98 
                 + t ++g++d++g ++v+i  +  + L  +t  t+ ++a+++D +++++++ 
  EFC37264.1 824 DVTSFEGTTDVNGeHQVAIAFDesDRL-VKTPVTISVEATVQDINRQTISSS 874
                 455666668899999998888865667.999*************99766553 PP

>> MG4  Macroglobulin domain MG4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       8.8   1.7e+04      47      69 ..     701     723 ..     690     724 .. 0.74
   2 ?   -3.6   0.1       6.5   1.3e+04      50      83 ..     830     867 ..     826     872 .. 0.68
   3 !   13.9   0.1   2.3e-05     0.046       6      41 ..     891     926 ..     888     944 .. 0.82
   4 ?   -3.3   0.0       5.1     1e+04      17      41 ..    1139    1164 ..    1130    1178 .. 0.76
   5 ?    1.4   0.0      0.18   3.6e+02      48      75 ..    1292    1319 ..    1273    1326 .. 0.79
   6 ?   -4.1   0.0         9   1.8e+04      50      64 ..    1408    1422 ..    1391    1430 .. 0.78

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 8.8
         MG4  47 keslttdedGtakfsintpedak 69 
                   ++t +edGt  + + +p++a+
  EFC37264.1 701 SGNVTLSEDGTFDIQFKVPDNAN 723
                 45677789999999999888765 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 6.5
         MG4  50 lttdedGtakfsintped....aksltitvktkdpslp 83 
                  ttd +G  ++ i   e+    ++ +ti v+   +++ 
  EFC37264.1 830 GTTDVNGEHQVAIAFDESdrlvKTPVTISVEATVQDIN 867
                 67888888888887777434556677777777666655 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 2.3e-05
         MG4   6 tpkffKpGlPfsikVlvkdpdgspaknvpVkiealk 41 
                 +++f Kp +P +  + v+d dg+ ++++p k++++ 
  EFC37264.1 891 SKQFAKPNIPITASLIVSDIDGKLVSGIPMKLKVTT 926
                 689*****************************9932 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 5.1
         MG4   17 sikVlvkdp.dgspaknvpVkiealk 41  
                  si V vkdp  g+p+++  V+i a++
  EFC37264.1 1139 SIDVIVKDPiTGKPLEGCEVCIIAVD 1164
                  78999999857999999999998865 PP

  == domain 5  score: 1.4 bits;  conditional E-value: 0.18
         MG4   48 eslttdedGtakfsintpedaksltitv 75  
                   + +t+++G+a++ + +p++ ++  it+
  EFC37264.1 1292 PTNKTNSEGVASVKFKLPDNLTKYRITA 1319
                  456799****************999996 PP

  == domain 6  score: -4.1 bits;  conditional E-value: 9
         MG4   50 lttdedGtakfsint 64  
                   ttd+ G+a+f + +
  EFC37264.1 1408 MTTDRVGVARFQVGV 1422
                  589999999998765 PP

>> TED_complement  A-macroglobulin TED domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   3.7e-05     0.075      20     110 ..    1496    1588 ..    1481    1605 .. 0.82
   2 ?    0.9   1.6     0.091   1.8e+02     185     241 ..    1608    1663 ..    1587    1701 .. 0.71
   3 ?   -3.7   0.0       2.3   4.6e+03      61      95 ..    1843    1875 ..    1839    1875 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.7e-05
                      HHHSSS--SSHHHHGGGTHHHHHHHHHHHHTTGTTTSHHHHHHHHHHHHHHHHHTCBETTSEBBSSS....SS-BEHHHHHHHHHHHHHCHHH CS
  TED_complement   20 esLlrlPygcgEqnmvllapnvyvlkYLekteqltkeikkkaleklekgyqrqlsykkadgsysafg.kd.ssegstWLtAfvlkvlaqakef 110 
                        L + P+ c Eq  + l + + + + L + +  +  +k+++ e++++g+ +  + + ++g++s ++ +  +++ s  +t  v  +la+a+  
      EFC37264.1 1496 LYLYNYPFACSEQISSRLLSILALKDILLAFKLQELPTKENLDENINQGLRQLSTRQYPNGGFSYWSfNGvDHRISPYVTCHVGHSLARARLA 1588
                      568889*******999999988888888888777777************988888889*********644899**************998754 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.091
                      HHHHHHHHHHS---HHHHHHHHHHHHHTT-THHHHHHHHHHHTTEEEETT..EEEE--T CS
  TED_complement  185 leyLeekqaeelesvyalAilaYalalakseekaeellksLkaeakeegn..svyWeed 241 
                       +y e+ ++e+++s+  +A + Yalal +++e a++l ++L +  k +gn  ++ W + 
      EFC37264.1 1608 ESYCENYSEETIKSL--KAYAYYALALLDDSE-AKNLAEKLYQTYKLSGNfeHLAWLAT 1663
                      555555444444443..67788*********9.9*************999444446555 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 2.3
                      HHHHHHHHHHHHHTCB.ETTSEBBSSS..SS-BEHH CS
  TED_complement   61 aleklekgyqrqlsyk.kadgsysafgkdssegstW 95  
                      +++ l  g+  q +y   +d+s+ +f    +e +tW
      EFC37264.1 1843 LVDALDYGFEVQRTYEhVTDSSHVTFD---RERNTW 1875
                      6889999********945889999999...668888 PP

>> DUF11  Domain of unknown function DUF11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.63   1.3e+03      10      30 ..    1351    1371 ..    1345    1376 .. 0.86
   2 ?   11.4   0.0   0.00016      0.31       6      51 ..    1869    1916 ..    1864    1933 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.63
       DUF11   10 vrpGdtvtytltvtNtgpasa 30  
                  +++Gd  ++t +++N+ + s+
  EFC37264.1 1351 LNFGDRAEFTCVLQNQTQLSL 1371
                  699************988776 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00016
       DUF11    6 dks....evrpGdtvtytltvtNtgpasangvvvtDtlPaglayvsvsas 51  
                  d++    ++++G+ v+  lt+tNt+ +    v + D lPagl+ +    +
  EFC37264.1 1869 DRErntwRFKAGELVRIKLTMTNTSRRYH--VALVDFLPAGLEPINPELK 1916
                  5555556899**************98877..***********98776655 PP

>> Big_1  Bacterial Ig-like domain (group 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.16   3.2e+02      14      35 ..     404     425 ..     401     433 .. 0.79
   2 ?   -2.8   0.0       3.3   6.5e+03      10      29 ..     688     707 ..     685     714 .. 0.80
   3 ?   -0.5   0.1      0.63   1.3e+03      35      51 ..     825     841 ..     818     844 .. 0.76
   4 ?   -2.4   0.1       2.6   5.1e+03       7      22 ..     857     872 ..     856     875 .. 0.80
   5 ?    4.9   0.0     0.013        25       7      33 ..     901     927 ..     900     934 .. 0.88
   6 ?   -2.7   0.0       3.2   6.4e+03       7      42 ..    1138    1174 ..    1136    1177 .. 0.72
   7 ?    5.5   0.0    0.0083        17      33      52 ..    1287    1306 ..    1276    1308 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.16
       Big_1  14 kDangnpvagatVtfsvsggal 35 
                 +D  g+ ++++tV f+v ++  
  EFC37264.1 404 VDVWGQILPDTTVEFTVKSARQ 425
                 5667999**********99544 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.3
       Big_1  10 tatvkDangnpvagatVtfs 29 
                 t tv Da g+     +Vt+s
  EFC37264.1 688 TFTVLDARGQKYHSGNVTLS 707
                 8899**99998777777776 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.63
       Big_1  35 lsassgtTdanGkatvt 51 
                 +++ +gtTd nG+ +v 
  EFC37264.1 825 VTSFEGTTDVNGEHQVA 841
                 447799******98886 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 2.6
       Big_1   7 ntltatvkDangnpva 22 
                 + + atv+D n + ++
  EFC37264.1 857 ISVEATVQDINRQTIS 872
                 6799*****9988776 PP

  == domain 5  score: 4.9 bits;  conditional E-value: 0.013
       Big_1   7 ntltatvkDangnpvagatVtfsvsgg 33 
                 +t++ +v D +g+ v+g++ +++v+ +
  EFC37264.1 901 ITASLIVSDIDGKLVSGIPMKLKVTTN 927
                 68999*****************99985 PP

  == domain 6  score: -2.7 bits;  conditional E-value: 3.2
       Big_1    7 ntltatvkD.angnpvagatVtfsvsggalsassgtT 42  
                  + + ++vkD   g+p++g +V + + ++a+++ +g T
  EFC37264.1 1138 TSIDVIVKDpITGKPLEGCEVCIIAVDEAVLSLTGHT 1174
                  5678999994589999999998777776666666666 PP

  == domain 7  score: 5.5 bits;  conditional E-value: 0.0083
       Big_1   33 galsassgtTdanGkatvtl 52  
                   a+++++ +T+++G+a+v++
  EFC37264.1 1287 LAIFSPTNKTNSEGVASVKF 1306
                  45669*************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2010 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       902  (0.0503096); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 1.18u 0.35s 00:00:01.52 Elapsed: 00:00:00.53
# Mc/sec: 11431.32
//
Query:       EFC37265.1  [L=445]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.6e-45  148.2  24.2    0.00037   20.3   0.1   13.2 13  LRR_6      Leucine Rich repeat
    1.1e-29  102.0  18.0    2.3e-07   30.5   0.2    6.3  8  LRR_8      Leucine rich repeat
    1.3e-22   79.4  31.2    0.00014   22.2   0.4    8.7 10  LRR_4      Leucine Rich repeats (2 copies)
    3.1e-11   42.2   5.7        9.8    7.2   0.1   10.5 10  LRR_1      Leucine Rich Repeat
  ------ inclusion threshold ------
      0.022   14.6   0.3         41    4.1   0.0    4.2  4  PapC_C     PapC C-terminal domain
      0.046   13.9   8.2      0.069   13.4   0.5    3.7  3  YjcQ       YjcQ protein
      0.067   12.9   6.1        1.1    9.0   0.1    3.8  5  DUF4869    Domain of unknown function (DUF4869)
       0.13   12.2   0.4         11    5.9   0.1    3.0  3  DUF2947    Protein of unknown function (DUF2947)
          2    9.2   7.2         11    6.8   0.2    4.4  5  PulA_N1    Pullulanase N1-terminal domain
        2.6    8.1   6.1         64    3.6   0.0    5.1  5  ApoB100_C  Apolipoprotein B100 C terminal
        2.9    8.0   7.7        1.2    9.3   1.2    3.2  3  NKWYS      Putative capsular polysaccharide synthesis protein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   6.7e-05      0.11       5      24 .]      65      84 ..      62      84 .. 0.91
   2 !   11.6   0.0   0.00014      0.23       3      24 .]      87     108 ..      85     108 .. 0.87
   3 !   15.8   0.0   6.2e-06      0.01       5      23 ..     113     131 ..     110     132 .. 0.91
   4 !   18.1   0.1   1.1e-06    0.0018       5      23 ..     137     155 ..     134     156 .. 0.92
   5 ?    4.0   0.0     0.039        64       7      24 .]     163     180 ..     158     180 .. 0.81
   6 ?    2.4   0.1      0.13   2.1e+02       4      13 ..     184     193 ..     183     198 .. 0.91
   7 !   17.3   0.0   2.2e-06    0.0035       4      23 ..     208     227 ..     205     228 .. 0.90
   8 ?    1.2   0.0      0.31     5e+02      12      22 ..     240     250 ..     232     251 .. 0.82
   9 !   20.3   0.1   2.2e-07   0.00037       4      24 .]     256     276 ..     256     276 .. 0.93
  10 !   17.5   0.0   1.9e-06     0.003       5      23 ..     281     299 ..     278     300 .. 0.91
  11 !    7.3   0.0    0.0035       5.7       5      24 .]     305     324 ..     301     324 .. 0.88
  12 !   14.8   0.0   1.3e-05     0.022       4      24 .]     328     348 ..     325     348 .. 0.91
  13 !    9.6   0.0   0.00063         1       4      23 ..     352     371 ..     349     372 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6.7e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt Ld+ gN+I+ eGa+ ++
  EFC37265.1 65 LTQLDIDGNNIDEEGAKYIS 84
                9***************9875 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00014
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L  L++ gN+Ig+eG++ ++
  EFC37265.1  87 QYLAILNMLGNNIGNEGVKYIS 108
                 578899999*********9875 PP

  == domain 3  score: 15.8 bits;  conditional E-value: 6.2e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++s N+Ig +G++ +
  EFC37265.1 113 LTHLNVSENNIGLDGVKYI 131
                 9***************977 PP

  == domain 4  score: 18.1 bits;  conditional E-value: 1.1e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++  N IgDeGa+ +
  EFC37265.1 137 LTHLNIGQNSIGDEGAKLI 155
                 9***************987 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.039
       LRR_6   7 eLdLsgNdIgDeGaeaLa 24 
                  L + +++I+ eG++ ++
  EFC37265.1 163 DLCIFYCGISSEGIKHIS 180
                 566789********9986 PP

  == domain 6  score: 2.4 bits;  conditional E-value: 0.13
       LRR_6   4 hLteLdLsgN 13 
                 +Lt L++s+N
  EFC37265.1 184 KLTDLNISSN 193
                 69*******9 PP

  == domain 7  score: 17.3 bits;  conditional E-value: 2.2e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+L + +N+IgDeGa+ L
  EFC37265.1 208 QLTYLRIHDNNIGDEGAKFL 227
                 69***************977 PP

  == domain 8  score: 1.2 bits;  conditional E-value: 0.31
       LRR_6  12 gNdIgDeGaea 22 
                  N+++ eG++ 
  EFC37265.1 240 RNELTAEGVKF 250
                 79*******86 PP

  == domain 9  score: 20.3 bits;  conditional E-value: 2.2e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lte d+s+N+IgD Ga+ ++
  EFC37265.1 256 KLTEIDISSNNIGDNGAKYIS 276
                 69***************9885 PP

  == domain 10  score: 17.5 bits;  conditional E-value: 1.9e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt Ld+s+N+Ig eGa+ +
  EFC37265.1 281 LTNLDVSDNNIGEEGAKYI 299
                 9***************977 PP

  == domain 11  score: 7.3 bits;  conditional E-value: 0.0035
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L L  N+I +eGa+ ++
  EFC37265.1 305 LTILTLWKNNIRGEGAKYIS 324
                 89999999********9885 PP

  == domain 12  score: 14.8 bits;  conditional E-value: 1.3e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +LteLd+s N+I+ +Ga+ ++
  EFC37265.1 328 KLTELDISENHIDEKGAKYIS 348
                 8****************9875 PP

  == domain 13  score: 9.6 bits;  conditional E-value: 0.00063
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  L +Ld+s N Ig++Ga+ +
  EFC37265.1 352 QLNALDISVNIIGNQGAKYI 371
                 699**************976 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.017        27      48      61 .]      62      75 ..      59      75 .. 0.86
   2 !   22.3   0.7     5e-08   8.1e-05       2      61 .]      64     123 ..      63     123 .. 0.98
   3 !   22.4   1.3   4.7e-08   7.6e-05       3      61 .]      89     147 ..      87     147 .. 0.95
   4 !   15.4   0.5   7.3e-06     0.012       2      37 ..     112     147 ..     111     165 .. 0.81
   5 !   20.4   0.2   1.9e-07   0.00031      21      61 .]     179     219 ..     168     219 .. 0.92
   6 !   30.5   0.2   1.4e-10   2.3e-07       2      61 .]     232     291 ..     231     291 .. 0.97
   7 !   29.9   0.1   2.2e-10   3.6e-07       2      59 ..     304     361 ..     303     363 .. 0.97
   8 ?   -0.7   0.0      0.77   1.2e+03       2      13 ..     376     387 ..     370     390 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.017
                --S-.EEE--SS-- CS
       LRR_8 48 LpsLrsLdLsgNrL 61
                L++L++Ld++gN++
  EFC37265.1 62 LKQLTQLDIDGNNI 75
                88999999999987 PP

  == domain 2  score: 22.3 bits;  conditional E-value: 5e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt Ld++ N++ + + +  + ++ L +L++  N++     + +sg+++L++L++s N++
  EFC37265.1  64 QLTQLDIDGNNIDEEGAKYISEMQYLAILNMLGNNIGNEGVKYISGMKQLTHLNVSENNI 123
                 79********************************************************97 PP

  == domain 3  score: 22.4 bits;  conditional E-value: 4.7e-08
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L +L+   N++ + + +  +g+++L++L+ s+N++     + ++ +++L++L++ +N +
  EFC37265.1  89 LAILNMLGNNIGNEGVKYISGMKQLTHLNVSENNIGLDGVKYIVEMKQLTHLNIGQNSI 147
                 78899999************************************************986 PP

  == domain 4  score: 15.4 bits;  conditional E-value: 7.3e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37 
                 +Lt L++s N++   + +    +++L++L++++N++
  EFC37265.1 112 QLTHLNVSENNIGLDGVKYIVEMKQLTHLNIGQNSI 147
                 688888888888888888888888888888888887 PP

  == domain 5  score: 20.4 bits;  conditional E-value: 1.9e-07
                 STT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  21 FkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  ++l +L+ L++s+N l   s + +sg+++L++L + +N++
  EFC37265.1 179 ISKLDKLTDLNISSNMLYDDSTKYISGMNQLTYLRIHDNNI 219
                 56799**********************************97 PP

  == domain 6  score: 30.5 bits;  conditional E-value: 1.4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt +++++N lt+ + ++ +gl +L+++d+s+N++    ++ +s +++L+ Ld+s+N++
  EFC37265.1 232 QLTGINIWRNELTAEGVKFLTGLDKLTEIDISSNNIGDNGAKYISEMKQLTNLDVSDNNI 291
                 79999*****************************************************97 PP

  == domain 7  score: 29.9 bits;  conditional E-value: 2.2e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+L L++N++ + + +  ++l++L++Ld+s+N ++   ++ +s +++L  Ld+s N
  EFC37265.1 304 QLTILTLWKNNIRGEGAKYISKLEKLTELDISENHIDEKGAKYISEMSQLNALDISVN 361
                 79*****************************************************977 PP

  == domain 8  score: -0.7 bits;  conditional E-value: 0.77
                 T-SEEE-TTS-- CS
       LRR_8   2 nLtsLdLsnNrl 13 
                 +Lt L +++N++
  EFC37265.1 376 QLTDLLIWDNNI 387
                 688888888885 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.2    0.0052       8.4      22      39 ..      62      75 ..      43      79 .. 0.80
   2 !   11.6   0.7   0.00018       0.3       7      34 ..      93     122 ..      89     130 .. 0.75
   3 !   18.4   1.2   1.3e-06    0.0021       1      37 [.     111     148 ..     111     164 .. 0.81
   4 !    9.4   0.1    0.0009       1.5       1      29 [.     135     165 ..     135     173 .. 0.84
   5 !    8.1   0.6    0.0023       3.8       5      33 ..     163     193 ..     159     202 .. 0.75
   6 !   15.8   0.0   8.5e-06     0.014       2      39 ..     208     243 ..     207     252 .. 0.90
   7 !   22.2   0.4   8.3e-08   0.00014       2      34 ..     256     290 ..     255     297 .. 0.88
   8 !   19.4   0.9   6.4e-07     0.001       1      34 [.     279     314 ..     279     326 .. 0.89
   9 !   17.4   0.2   2.7e-06    0.0044       1      39 [.     303     339 ..     303     343 .. 0.87
  10 ?    5.0   0.2     0.021        35       3      37 ..     353     389 ..     351     395 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0052
                -TT--EEE-.-S-----G CS
       LRR_4 22 lpnLkeLdLsgNnlitdl 39
                l++L++Ld+ gN    ++
  EFC37265.1 62 LKQLTQLDIDGN----NI 75
                99*******999....44 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00018
                 E--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   7 dLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 +  +N++   +   ++++++L++L++s+Nn
  EFC37265.1  93 NMLGNNIGNEGVkyISGMKQLTHLNVSENN 122
                 55578888666676567*********9993 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 1.3e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 ++L++L+ s N++  +++   +  +++L++L++ +N  i+
  EFC37265.1 111 KQLTHLNVSENNIG-LDGvkyIVEMKQLTHLNIGQN-SIG 148
                 58*******88877.667555557*********666.554 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.0009
                 SS--EEE--SS---E-S-.HHH.-TT--EEE CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLd 29 
                 ++L++L++++N + d +  l + +++L  L 
  EFC37265.1 135 KQLTHLNIGQNSIGDEGAkLIGeMTQLLDLC 165
                 58*************9999666699998885 PP

  == domain 5  score: 8.1 bits;  conditional E-value: 0.0023
                 EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   5 vLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                  L+++ + +++ +   ++kl++L+ L++s+N
  EFC37265.1 163 DLCIFYCGISSEGIkhISKLDKLTDLNISSN 193
                 5667778888777776778*********999 PP

  == domain 6  score: 15.8 bits;  conditional E-value: 8.5e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +L++L +++N++ d +   l+k+++L+ +++++N     l
  EFC37265.1 208 QLTYLRIHDNNIGDEGAkfLGKMKQLTGINIWRN----EL 243
                 69************999*8889************....44 PP

  == domain 7  score: 22.2 bits;  conditional E-value: 8.3e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 +L+++d+s+N++ d +   ++ +++L+ Ld+s+Nn
  EFC37265.1 256 KLTEIDISSNNIGDNGAkyISEMKQLTNLDVSDNN 290
                 8*************99986445*********9994 PP

  == domain 8  score: 19.4 bits;  conditional E-value: 6.4e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++Ld s+N++ + +   ++++++L+ L+L+ Nn
  EFC37265.1 279 KQLTNLDVSDNNIGEEGAkyIGNMKQLTILTLWKNN 314
                 58************988887778***********95 PP

  == domain 9  score: 17.4 bits;  conditional E-value: 2.7e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++L L  N+++  +   ++kl +L+eLd+s+N     +
  EFC37265.1 303 KQLTILTLWKNNIRGEGAkyISKLEKLTELDISEN----HI 339
                 58************988887778*********999....44 PP

  == domain 10  score: 5.0 bits;  conditional E-value: 0.021
                 --EEE--SS---E-S-..HHH.-TT--EEE-..-S---- CS
       LRR_4   3 LevLdLsnNqltdipl..lek.lpnLkeLdL.sgNnlit 37 
                 L  Ld+s N +   +   + k +++L+ L L ++Nn i+
  EFC37265.1 353 LNALDISVNIIGNQGAkyI-KeMKQLTDL-LiWDNNIIE 389
                 6679999666665555633.449999999.779999886 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0      0.19   3.1e+02       2      17 ..      65      80 ..      64      86 .. 0.76
   2 ?    3.7   0.0     0.085   1.4e+02       1      12 [.     112     123 ..     112     131 .. 0.81
   3 !    7.2   0.1     0.006       9.8       1      17 [.     136     152 ..     136     182 .. 0.79
   4 ?    1.5   0.0      0.44   7.2e+02       1      12 [.     184     195 ..     184     206 .. 0.83
   5 ?    1.2   0.0      0.57   9.2e+02       1      19 [.     208     226 ..     208     230 .. 0.78
   6 ?    5.7   0.0     0.018        29       1      18 [.     256     273 ..     256     278 .. 0.79
   7 ?    3.0   0.0      0.15   2.4e+02       2      20 ..     281     299 ..     280     302 .. 0.76
   8 ?   -0.2   0.0       1.5   2.5e+03       2      23 .]     305     326 ..     304     326 .. 0.84
   9 ?    5.1   0.0      0.03        48       1      20 [.     328     347 ..     328     350 .. 0.81
  10 ?    0.3   0.0       1.1   1.7e+03       2      18 ..     353     369 ..     352     390 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.19
       LRR_1  2 LrhLdLsnnpllglpp 17
                L+ Ld+ +n+++  ++
  EFC37265.1 65 LTQLDIDGNNIDEEGA 80
                899******9965555 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.085
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+hL++s n++
  EFC37265.1 112 QLTHLNVSENNI 123
                 59*****99887 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.006
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L+hL++++n++++ ++
  EFC37265.1 136 QLTHLNIGQNSIGDEGA 152
                 59*********955443 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.44
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+ L++s+n l
  EFC37265.1 184 KLTDLNISSNML 195
                 7999******76 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.57
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L + +n++++ ++  
  EFC37265.1 208 QLTYLRIHDNNIGDEGAKF 226
                 599*******998776655 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.018
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L+++d+s+n++++ ++ 
  EFC37265.1 256 KLTEIDISSNNIGDNGAK 273
                 79********99776655 PP

  == domain 7  score: 3.0 bits;  conditional E-value: 0.15
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ Ld+s+n+++  ++ ++
  EFC37265.1 281 LTNLDVSDNNIGEEGAKYI 299
                 899*******976666555 PP

  == domain 8  score: -0.2 bits;  conditional E-value: 1.5
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ L L  n++ g ++ ++++L
  EFC37265.1 305 LTILTLWKNNIRGEGAKYISKL 326
                 89999*9999989988888876 PP

  == domain 9  score: 5.1 bits;  conditional E-value: 0.03
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+s n+++ +++ ++
  EFC37265.1 328 KLTELDISENHIDEKGAKYI 347
                 79*********977776655 PP

  == domain 10  score: 0.3 bits;  conditional E-value: 1.1
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L  Ld+s n++++ ++ 
  EFC37265.1 353 LNALDISVNIIGNQGAK 369
                 56799999998555444 PP

>> PapC_C  PapC C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.025        41      29      50 ..      99     120 ..      90     123 .. 0.88
   2 ?   -2.2   0.0       2.2   3.6e+03      31      49 ..     197     215 ..     190     222 .. 0.67
   3 ?    3.7   0.0     0.034        55      28      52 ..     266     290 ..     255     309 .. 0.90
   4 ?    0.9   0.0      0.25   4.1e+02      26      47 ..     360     381 ..     340     386 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.025
                 B-CCCEEEEECE-SEEEEEEES CS
      PapC_C  29 VgqgGqvylrglpdqgtLtvkw 50 
                 +g++G  y++g+++  +L+v+ 
  EFC37265.1  99 IGNEGVKYISGMKQLTHLNVSE 120
                 79****************9975 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2.2
                 CCCEEEEECE-SEEEEEEE CS
      PapC_C  31 qgGqvylrglpdqgtLtvk 49 
                 +++  y++g+ +   L+++
  EFC37265.1 197 DDSTKYISGMNQLTYLRIH 215
                 5556677777766666665 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.034
                 EB-CCCEEEEECE-SEEEEEEES-S CS
      PapC_C  28 iVgqgGqvylrglpdqgtLtvkwge 52 
                  +g++G  y++ +++  +L+v+ ++
  EFC37265.1 266 NIGDNGAKYISEMKQLTNLDVSDNN 290
                 489*****************98765 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.25
                 -EEB-CCCEEEEECE-SEEEEE CS
      PapC_C  26 vgiVgqgGqvylrglpdqgtLt 47 
                 v i+g++G  y+  +++   L 
  EFC37265.1 360 VNIIGNQGAKYIKEMKQLTDLL 381
                 6799999999999998877665 PP

>> YjcQ  YjcQ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.5   4.2e-05     0.069      20      79 ..      73     133 ..      54     140 .. 0.87
   2 ?   -1.6   0.0         2   3.3e+03      61      78 ..     235     252 ..     217     260 .. 0.79
   3 ?    2.5   0.6       0.1   1.6e+02      47      83 ..     317     353 ..     273     364 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 4.2e-05
                 S---HHH.HTS-HHHHHHHHHHHHHHTSEE--EESSS...SEE--SS--EE-HHHHHHHHH CS
        YjcQ  20 kelsaek.ldisesrfndiiemlveegyikGvkvkktkkgeivisidnvritlkGleyLke 79 
                 +++++e    ise ++ +i++ml ++   +Gvk+++  k   ++++++ +i l+G++y+ e
  EFC37265.1  73 NNIDEEGaKYISEMQYLAILNMLGNNIGNEGVKYISGMKQLTHLNVSENNIGLDGVKYIVE 133
                 5676666245*****************************99*****************987 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 2
                 E--SS--EE-HHHHHHHH CS
        YjcQ  61 visidnvritlkGleyLk 78 
                  i+i + ++t +G+++L 
  EFC37265.1 235 GINIWRNELTAEGVKFLT 252
                 467777889999999985 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.1
                 EE--EESSS...SEE--SS--EE-HHHHHHHHHHT-S CS
        YjcQ  47 ikGvkvkktkkgeivisidnvritlkGleyLkeNsmm 83 
                  +G k++++ +    + i++ +i +kG +y++e s++
  EFC37265.1 317 GEGAKYISKLEKLTELDISENHIDEKGAKYISEMSQL 353
                 3566666666667788899999999999999998876 PP

>> DUF4869  Domain of unknown function (DUF4869)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.58   9.5e+02      71     102 ..     118     149 ..      94     161 .. 0.62
   2 ?    0.6   0.1      0.26   4.3e+02      56      95 ..     127     166 ..     109     194 .. 0.77
   3 ?    9.0   0.1   0.00066       1.1      54     104 ..     245     295 ..     228     313 .. 0.85
   4 ?   -0.8   0.0      0.72   1.2e+03      80     114 ..     319     354 ..     299     362 .. 0.73
   5 ?    3.6   0.1     0.032        52      63     115 ..     350     402 ..     333     413 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.58
     DUF4869  71 fnvsacGdnCakwlleiakkkdltinlrhimd 102
                 +   ++G + +k+++e+ + ++l i  + i d
  EFC37265.1 118 VSENNIGLDGVKYIVEMKQLTHLNIGQNSIGD 149
                 44445666677777777776666665555444 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.26
     DUF4869  56 GvktLlllanedekifnvsacGdnCakwlleiakkkdlti 95 
                 Gvk ++ +++  +  +   ++Gd  ak++ e+++  dl i
  EFC37265.1 127 GVKYIVEMKQLTHLNIGQNSIGDEGAKLIGEMTQLLDLCI 166
                 7777777777777777777788888888888888777776 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00066
     DUF4869  54 sgGvktLlllanedekifnvsacGdnCakwlleiakkkdltinlrhimdfg 104
                 + Gvk L  l +  e  +   ++Gdn ak++ e+ + ++l ++ ++i + g
  EFC37265.1 245 AEGVKFLTGLDKLTEIDISSNNIGDNGAKYISEMKQLTNLDVSDNNIGEEG 295
                 459999999999999999999***************999999877776655 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 0.72
     DUF4869  80 CakwlleiakkkdltinlrhimdfgekkF.eikiln 114
                  ak++ ++ k ++l i+ +hi + g k   e++ ln
  EFC37265.1 319 GAKYISKLEKLTELDISENHIDEKGAKYIsEMSQLN 354
                 588999999999999999998888755432444455 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.032
     DUF4869  63 lanedekifnvsacGdnCakwlleiakkkdltinlrhimdfgekkFeikilnt 115
                 + + +   + v  +G+  ak++ e+ + +dl i  ++i++  e+  eik + t
  EFC37265.1 350 MSQLNALDISVNIIGNQGAKYIKEMKQLTDLLIWDNNIIEQEEHPKEIKEVST 402
                 555555566788899*****************999999998888877776665 PP

>> DUF2947  Protein of unknown function (DUF2947)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.72   1.2e+03      16      49 ..     215     248 ..     210     284 .. 0.78
   2 ?    2.5   0.0     0.075   1.2e+02      16      50 ..     287     321 ..     274     353 .. 0.78
   3 ?    5.9   0.1    0.0066        11      22      57 ..     365     400 ..     354     414 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.72
     DUF2947  16 kdlpvseedlaeikplsekraaqvWkenisaess 49 
                 +d ++ +e  + +  +++ +  ++W++++ ae  
  EFC37265.1 215 HDNNIGDEGAKFLGKMKQLTGINIWRNELTAEGV 248
                 5778889999999999999999***999887754 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.075
     DUF2947  16 kdlpvseedlaeikplsekraaqvWkenisaesse 50 
                 +d ++ ee  + i  +++ +  ++Wk+ni  e ++
  EFC37265.1 287 SDNNIGEEGAKYIGNMKQLTILTLWKNNIRGEGAK 321
                 678899999********************866433 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0066
     DUF2947  22 eedlaeikplsekraaqvWkenisaesseaerlskk 57 
                 ++  + ik +++ +   +W++ni +++++++++++ 
  EFC37265.1 365 NQGAKYIKEMKQLTDLLIWDNNIIEQEEHPKEIKEV 400
                 667889***********************9988765 PP

>> PulA_N1  Pullulanase N1-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       6.4     1e+04      28      47 ..      16      35 ..      11      39 .. 0.71
   2 ?    0.8   0.0      0.53   8.6e+02      27      60 ..     105     138 ..      79     153 .. 0.70
   3 ?    1.4   0.0      0.33   5.4e+02      29      56 ..     179     206 ..     167     213 .. 0.82
   4 ?    1.0   0.0      0.44   7.2e+02       5      56 ..     254     302 ..     250     306 .. 0.71
   5 ?    6.8   0.2    0.0068        11       4      74 ..     298     368 ..     296     374 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 6.4
                EEEESSEEEEEEEEEEEEES CS
     PulA_N1 28 llkeedekieLeikekeele 47
                 + +e +k +L+ik+ ++++
  EFC37265.1 16 KVISERSKLSLSIKSYQKIQ 35
                55567788889998887776 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.53
                 EEEEESSEEEEEEEEEEEEESSEEEEEEE-SS-- CS
     PulA_N1  27 fllkeedekieLeikekeeleeevkYvckleeel 60 
                  +++  ++ ++L++ e     + vkY++++++  
  EFC37265.1 105 KYISGMKQLTHLNVSENNIGLDGVKYIVEMKQLT 138
                 3677888999999999999999999999987644 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.33
                 EEESSEEEEEEEEEEEEESSEEEEEEE- CS
     PulA_N1  29 lkeedekieLeikekeeleeevkYvckl 56 
                 +++ d+ ++L+i + +  ++++kY+  +
  EFC37265.1 179 ISKLDKLTDLNISSNMLYDDSTKYISGM 206
                 567788899***************9765 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.44
                 EEETTEEEEEEEGGGTTTS-S-EEEEESSEEEEEEEEEEEEESSEEEEEEE- CS
     PulA_N1   5 LDelntItillpksyeegesssfllkeedekieLeikekeeleeevkYvckl 56 
                 LD+l++I i  ++    g+    +++e ++ ++L++ +    ee  kY+ ++
  EFC37265.1 254 LDKLTEIDISSNNI---GDNGAKYISEMKQLTNLDVSDNNIGEEGAKYIGNM 302
                 78888888843333...33334478888999999999999999999998765 PP

  == domain 5  score: 6.8 bits;  conditional E-value: 0.0068
                 EEEETTEEEEE.EEGGGTTTS-S-EEEEESSEEEEEEEEEEEEESSEEEEEEE-SS---TTS--EEE-TTS- CS
     PulA_N1   4 YLDelntItil.lpksyeegesssfllkeedekieLeikekeeleeevkYvckleeelelgkeylildehgn 74 
                 Y+ +++++til l k+   ge ++ ++++ ++ +eL+i e +  e+  kY+ ++++   l+ +  i+ ++g 
  EFC37265.1 298 YIGNMKQLTILtLWKNNIRGEGAK-YISKLEKLTELDISENHIDEKGAKYISEMSQLNALDISVNIIGNQGA 368
                 667788888863344444555444.78889999********************9999888888888877776 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1       1.1   1.8e+03      19      38 ..      16      34 ..      11      49 .. 0.75
   2 ?    3.6   0.0     0.039        64      18      32 ..     152     166 ..     143     168 .. 0.86
   3 ?   -0.8   0.0      0.97   1.6e+03      19      34 ..     177     192 ..     172     209 .. 0.81
   4 ?   -0.5   0.0      0.75   1.2e+03      10      32 ..     264     286 ..     255     288 .. 0.77
   5 ?    1.7   0.0      0.16   2.5e+02      19      32 ..     369     382 ..     356     386 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.1
   ApoB100_C 19 kliaeskrLiDLsIekYhaf 38
                k+i+e  +L  LsI++Y+ +
  EFC37265.1 16 KVISERSKL-SLSIKSYQKI 34
                778888887.5999999865 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.039
   ApoB100_C  18 EkliaeskrLiDLsI 32 
                  kli e ++L DL I
  EFC37265.1 152 AKLIGEMTQLLDLCI 166
                 59***********98 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.97
   ApoB100_C  19 kliaeskrLiDLsIek 34 
                 k i++  +L DL I +
  EFC37265.1 177 KHISKLDKLTDLNISS 192
                 5688889999999975 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.75
   ApoB100_C  10 sdqlsdyyEkliaeskrLiDLsI 32 
                 s+ + d   k i+e k+L  L +
  EFC37265.1 264 SNNIGDNGAKYISEMKQLTNLDV 286
                 566777778999****9998866 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.16
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k i e k+L DL I
  EFC37265.1 369 KYIKEMKQLTDLLI 382
                 889*********98 PP

>> NKWYS  Putative capsular polysaccharide synthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.2      0.43     7e+02      41     100 ..      62     122 ..      28     161 .. 0.79
   2 ?    9.3   1.2   0.00074       1.2      39     109 ..     276     349 ..     265     365 .. 0.79
   3 ?    3.3   0.5     0.052        84      40     100 ..     325     386 ..     320     400 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.43
       NKWYS  41 lkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikdfLnidnvklkksn 100
                 lk+++ +D+  +++d++   +i + +   +l +  +++ +   k+i  +  +  +++ ++n
  EFC37265.1  62 LKQLTQLDIDGNNIDEEGAKYISEMQYLAILNMLGNNIGNEgVKYISGMKQLTHLNVSENN 122
                 7888999999999998888788777777777665555544447777777666666666666 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00074
       NKWYS  39 nElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikdfLnidnvklkksn..eaknKwYse 109
                  E+k+++ +Dv ++++ ++   +i n k+  +l +  +++     k+i ++  + ++++ ++   e   K+ se
  EFC37265.1 276 SEMKQLTNLDVSDNNIGEEGAKYIGNMKQLTILTLWKNNIRGEgAKYISKLEKLTELDISENHidEKGAKYISE 349
                 69*****************999*********9988666655555*******99999998755311333455554 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.052
       NKWYS  40 ElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikdfLnidnvklkksn 100
                  l+k++ +D+ ++++d++   +i +  + + l i ++++ ++  k+ik++  + ++ +  +n
  EFC37265.1 325 KLEKLTELDISENHIDEKGAKYISEMSQLNALDISVNIIGNQgAKYIKEMKQLTDLLIWDNN 386
                 5889999*********9999999999999999999999988879999998877777666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       433  (0.0241508); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.52u 0.25s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 3097.81
//
Query:       EFC37266.1  [L=108]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0082   16.3   0.2     0.0082   16.3   0.2    2.0  2  Ribosomal_S30  Ribosomal protein S30
  ------ inclusion threshold ------
      0.096   12.8   1.7       0.13   12.4   1.7    1.3  1  Bromo_TP_like  Histone-fold protein


Domain annotation for each model (and alignments):
>> Ribosomal_S30  Ribosomal protein S30
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.2   9.1e-07    0.0082       8      32 ..       7      33 ..       6      51 .. 0.82
   2 ?   -1.3   0.4       0.3   2.7e+03      53      53 ..      91      91 ..      71     107 .. 0.52

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 9.1e-07
                   TTTHHHHH.S-------.------THH CS
  Ribosomal_S30  8 rAGKVrnq.TPKveKqe.kkKkptGRa 32
                   r GKVr + TPKveK + ++K + G+ 
     EFC37266.1  7 RTGKVRYHtTPKVEKINtEHKYKGGKH 33
                   78****7537******65999887765 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.3
                   S CS
  Ribosomal_S30 53 k 53
                    
     EFC37266.1 91 W 91
                   1 PP

>> Bromo_TP_like  Histone-fold protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.7   1.4e-05      0.13      59      91 ..      46      78 ..       8      98 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.4e-05
  Bromo_TP_like 59 lleeslgedsYkrnELlsFLkyqlnlkkqlktk 91
                     ++    d Y+r EL+s Lky+  lk+q+k+ 
     EFC37266.1 46 QFDNYNNADRYQRLELISALKYETLLKNQMKDI 78
                   3467778899*******************9964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       815  (0.0454571); expected 358.6 (0.02)
Passed bias filter:                      258  (0.0143901); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 734.80
//
Query:       EFC37267.1  [L=923]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.6e-08   32.3   0.2     0.0018   18.0   0.2    2.9  2  TPR_1     Tetratricopeptide repeat
    9.8e-08   31.6   0.1    0.00027   20.8   0.2    2.7  2  TPR_2     Tetratricopeptide repeat
    0.00022   21.8   0.0     0.0004   21.0   0.0    1.4  1  TPR_16    Tetratricopeptide repeat
     0.0003   20.9   0.0    0.00061   19.9   0.0    1.5  1  TPR_9     Tetratricopeptide repeat
     0.0013   18.4   0.0     0.0034   17.0   0.0    1.8  1  TPR_11    TPR repeat
     0.0035   17.6   0.2      0.015   15.6   0.2    2.2  1  TPR_17    Tetratricopeptide repeat
     0.0042   17.2   0.1       0.36   11.2   0.1    3.0  2  TPR_8     Tetratricopeptide repeat
     0.0054   17.0   0.1      0.087   13.1   0.2    2.3  2  TPR_12    Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.014   15.9   0.0      0.031   14.8   0.0    1.6  1  TPR_19    Tetratricopeptide repeat
      0.055   14.1   0.1       0.61   10.8   0.1    2.5  2  TPR_6     Tetratricopeptide repeat
      0.082   13.1   0.1       0.27   11.5   0.1    1.8  1  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
       0.12   13.3   0.1       0.48   11.4   0.0    2.0  1  TPR_14    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.2   1.2e-06    0.0018       8      34 .]     549     575 ..     545     575 .. 0.93
   2 !   11.3   0.0   0.00016      0.24       2      27 ..     577     602 ..     576     604 .. 0.86

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.2e-06
                 HHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   8 GnayfklgkydeAleyyekALelnPnn 34 
                 Gn +f+ +k++eA e+y+ A + +Pn+
  EFC37267.1 549 GNDLFREKKFEEARECYNTATKRYPND 575
                 8999*********************97 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00016
                 HHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekA 27 
                 ++l n+++++ klg++ +A  + + +
  EFC37267.1 577 RVLSNRALCLIKLGNFYQAFNDLSTV 602
                 689****************8887665 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.2   1.8e-07   0.00027       6      34 .]     547     575 ..     545     575 .. 0.93
   2 !    7.8   0.0    0.0027       4.1       2      26 ..     577     601 ..     576     605 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 1.8e-07
       TPR_2   6 nlGlayyklgdyeeAleafekAleldPnn 34 
                 + G+ +++ +++eeA+e+++ A + +Pn+
  EFC37267.1 547 EAGNDLFREKKFEEARECYNTATKRYPND 575
                 5799***********************97 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0027
       TPR_2   2 ealynlGlayyklgdyeeAleafek 26 
                 ++l n++l+++klg++ +A +++  
  EFC37267.1 577 RVLSNRALCLIKLGNFYQAFNDLST 601
                 5799************999887765 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   2.7e-07    0.0004       3      50 ..     548     592 ..     546     598 .. 0.93

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 2.7e-07
      TPR_16   3 laraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrl 50 
                 ++++++r +++++A++ +++a+kr+   P + + l ++++++ ++g++
  EFC37267.1 548 AGNDLFREKKFEEARECYNTATKRY---PNDSRVLSNRALCLIKLGNF 592
                 79***********************...99999********9999875 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   4.1e-07   0.00061       6      60 ..     553     607 ..     550     630 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 4.1e-07
       TPR_9   6 ireedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalap 60 
                  re+++e+a ++++      P+d + +  R+l+l +lG++ +A +dL + +a   
  EFC37267.1 553 FREKKFEEARECYNTATKRYPNDSRVLSNRALCLIKLGNFYQAFNDLSTVIADKN 607
                 699*********************************************9996554 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   2.3e-06    0.0034       1      42 []     549     590 ..     549     590 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 2.3e-06
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayykqG 42 
                 G+ ++   k+eeA e+Y++A k  P++ ++++n++l + k+G
  EFC37267.1 549 GNDLFREKKFEEARECYNTATKRYPNDSRVLSNRALCLIKLG 590
                 999******************************998877776 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.2     1e-05     0.015       1      31 [.     564     594 ..     564     596 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1e-05
      TPR_17   1 lylkaleldPnnadaynnLAelllknGdlmt 31 
                 +y  a +++Pn++ ++ n+A +l k+G++ +
  EFC37267.1 564 CYNTATKRYPNDSRVLSNRALCLIKLGNFYQ 594
                 89*************************9755 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.1   0.00024      0.36      11      34 .]     552     575 ..     543     575 .. 0.84
   2 ?    2.5   0.0      0.14   2.1e+02       2      24 ..     577     599 ..     576     603 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00024
                 HHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8  11 ylklgdyeeAkeyyekaleldpdn 34 
                 ++  +++eeA e+y+ a++  p++
  EFC37267.1 552 LFREKKFEEARECYNTATKRYPND 575
                 67889***************9986 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.14
                 CHHHHHHHHHHHTT-HHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyy 24 
                 +++ n +++++klg++ +A   +
  EFC37267.1 577 RVLSNRALCLIKLGNFYQAFNDL 599
                 678899**********9997765 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   0.2   5.8e-05     0.087       5      64 ..     544     595 ..     540     600 .. 0.81
   2 ?    5.9   0.0     0.011        16       4      29 ..     577     602 ..     574     610 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 5.8e-05
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeA 64 
                 ++++ ++ l+r ++++eA+e++++a  ++     p+    +++l n + ++ +lg++ +A
  EFC37267.1 544 MYTEAGNDLFREKKFEEARECYNTATKRY-----PN---DSRVLSNRALCLIKLGNFYQA 595
                 7878999******************5555.....44...588999999999888887666 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.011
      TPR_12   4 talnnlaavlrrlgrydeAlelleka 29 
                 ++l+n+a++l +lg++ +A+  l ++
  EFC37267.1 577 RVLSNRALCLIKLGNFYQAFNDLSTV 602
                 6899***************9988776 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0   2.1e-05     0.031       1      44 [.     552     595 ..     552     609 .. 0.93

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.1e-05
      TPR_19   1 llaegdyaeAlalleqalqedpknaearllLAeallalgqldeA 44 
                 l+ e++++eA + +  a + +p++++++ + A +l++lg++ +A
  EFC37267.1 552 LFREKKFEEARECYNTATKRYPNDSRVLSNRALCLIKLGNFYQA 595
                 578999**********************************9887 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   0.00041      0.61      11      32 ..     553     574 ..     547     575 .. 0.86
   2 ?   -0.3   0.0       1.5   2.2e+03       5      27 ..     581     603 ..     578     605 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00041
                 HHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6  11 rklgdtdkAlealerlikeYPd 32 
                 ++ ++ ++A+e ++   k+YP+
  EFC37267.1 553 FREKKFEEARECYNTATKRYPN 574
                 55569****************9 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 1.5
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealerli 27 
                 ++al+++klg+  +A   l  +i
  EFC37267.1 581 NRALCLIKLGNFYQAFNDLSTVI 603
                 689*****999999987777666 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   0.00018      0.27      31      76 ..     550     596 ..     540     602 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00018
                 HHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHH CS
      ANAPC3  31 lclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAi 76 
                   l++ +++++A e +++a k ++++ +++   A cl+kL+++ +A 
  EFC37267.1 550 NDLFREKKFEEARECYNTAtKRYPNDSRVLSNRALCLIKLGNFYQAF 596
                 5699************************************9999886 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00032      0.48       7      38 ..     548     579 ..     539     587 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00032
      TPR_14   7 laeallalGdpdeAiallrralalaPddaeaw 38 
                 ++  l++  +++eA+++++ a +++P+d +++
  EFC37267.1 548 AGNDLFREKKFEEARECYNTATKRYPNDSRVL 579
                 4556788888******************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (923 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1792  (0.0999498); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.86u 0.30s 00:00:01.15 Elapsed: 00:00:00.50
# Mc/sec: 5537.10
//
Query:       EFC37268.1  [L=993]
Description: cytochrome p450 family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-87  294.5   0.5    2.2e-87  293.7   0.5    1.2  1  p450      Cytochrome P450
    1.1e-06   27.9   1.5    1.7e-06   27.3   1.5    1.2  1  TMEM151   TMEM151 family


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  293.7   0.5   2.5e-91   2.2e-87      40     444 ..     124     527 ..      87     540 .. 0.88

  Alignments for each domain:
  == domain 1  score: 293.7 bits;  conditional E-value: 2.5e-91
                 EETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHHTSHSTTTHHHHHHHHHHHHHHHHHCCCCHCS. CS
        p450  40 klgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltptltsfgklsleelveeeaedlveklrkkagess. 137
                 ++g+ pv+++s+p+a+k ++ k++ +++++ d+  ++   + f g +v+fang+ w+k+R++++p+++  +++++++ + + +++ v+ l++ +g +s 
  EFC37268.1 124 FIGNIPVMMVSTPSAAKTIFLKWK-DVEKD-DSLIFSEDMQKFFGVNVVFANGDVWRKHRTIINPAFF--KIERFTDCFVRNSQKAVDLLKELSGGKSq 218
                 58999******************5.88887.8999999999***************************..4689*********************9999 PP

                 .EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSH...........HHHHHHHHHHHHHHHHCHHHHCCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHH CS
        p450 138 .elditellskaaldvigsilFgarfdlledek...........lselvkaveelssllskssvqllllfpllkylptkllrklkeavkklkdlldkli 224
                  e+++++l +++aldv+g +++g+ fd l ++            ++++++a + +++++ +   +l+l +  +  lp +++rk++   +++++++ ++i
  EFC37268.1 219 fEISPSDLTTRMALDVLGLCMLGVDFDYL-NQIipnrgnkdsekNLKALAAYHYVMNNMGN-AARLFLGKA-FTKLPLEQNRKMDMSIEEFNKFIGEMI 314
                 99*************************55.5555999999877766677777777666644.446666666.667999********************* PP

                 HHHHHCHCHCSCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCCTTT.T-HHHHCCT-H CS
        p450 225 eerretldsakksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlgdkr.eptyddlqklp 322
                 e++r++ d+a   + ++l+ ++++  +++g+  ls+e++++++ ++++aG++Tt+ +l++ +y Lak+P+vqekl +Ei+e++g+++    y+ +q+++
  EFC37268.1 315 EDCRKSKDPA--MEDTLLKMMVDS-VDEEGN-GLSNEDIKNNTAVFFLAGHETTAVALAFLFYSLAKHPHVQEKLLNEINETFGSNEdLSNYEKIQSMK 409
                 **********..455555555555.477776.8**************************************************77764788******** PP

                 HHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTS.SSTTS--GGGGB-TTSCTESSCTT--TTEEGGGS-TTHHHHHH CS
        p450 323 yldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevf.pnPeeFdpeRFldekgnskrksfaflPFGaGpRnCiGerlArm 420
                 yld vikE LR++p++p l pR++ ++ vi+gy+ipkG   i+n+yalhr+ + + +++eeF+peRF +        + +f+PFG+GpR+C G  + ++
  EFC37268.1 410 YLDCVIKENLRIYPPIPQLPPRRLATPQVIDGYKIPKGFLLILNIYALHRNRDAWgQDAEEFKPERFMQS-----IVPNSFVPFGNGPRICSGIDFSKL 503
                 *****************9999***********************************************99.....5699******************** PP

                 HHHHHHHHHHHHEEEEESTSTSGG CS
        p450 421 elklflatlLqnFevelqpetdpp 444
                 e k f++++Lq+F+++l + +++ 
  EFC37268.1 504 EQKAFIISILQKFRIDLAHPNQEM 527
                 ****************97755443 PP

>> TMEM151  TMEM151 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   1.5   1.9e-10   1.7e-06      75     303 ..     637     859 ..     627     894 .. 0.85

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 1.9e-10
     TMEM151  75 llmLyvvylveCwhcraksellakadvesvlervqrlqqatPciWWkaisyhyvrrtrqvtryrnGDaytttqvyhervnthvaesefdysrcGvkDvs 173
                 ll L + y++  + + + + l + +  + vle v++ ++ +P i     ++hy  rt   tr  nG + t t     rv th+ + +  ++ +  +D s
  EFC37268.1 637 LLTLLIFYIIGIYASPTYHYLINFQMNNRVLEIVEETKKEKPEIVLTVECFHYETRTH-TTRDANGHTRTHTT--TVRVVTHTESRTLPFEFH--RDFS 730
                 5667899****************999****************************9996.69*****9877655..469999999988888765..9*** PP

     TMEM151 174 kellglek.hpvtrlrltkcfsfasaeaeneyltqrarffseneglDDyleareGmdlknvdfreellafvdPerkPWytsrvvfWlasllllsWPLrv 271
                  ++   ++    ++l +t+     + e+++   + r   +  n g+D +++  e       +f+ + l+++   r+P  ++   +  + l+ + W   +
  EFC37268.1 731 PQFSFKNTnKIFIKLDMTQQVFVNDGESKKILDQERIAIYIANRGRDTHMDYFENWG--TPNFQGQYLTCNPNLRTPRIATPFWYLTFCLFFVGWIYTI 827
                 9997655505568******9988999999999999******************9765..56699999**99999********99999************ PP

     TMEM151 272 laeyrtayvhyqvekLfGledtpsseseeees 303
                   + r    +y   k +  +  ++ +++++ +
  EFC37268.1 828 WFNKRCDAQDYTFIKQLSYQPFNDGQTDNNTD 859
                 ************99999866666655555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (993 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.52
# Mc/sec: 5761.39
//
Query:       EFC37269.1  [L=530]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.9e-34  116.0   0.7    2.8e-33  114.4   0.2    2.1  2  MVP_shoulder  Shoulder domain
    1.4e-16   60.3   0.5    8.6e-09   35.3   0.0    4.6  4  Vault_3       Major Vault Protein Repeat domain
    1.4e-09   37.8   0.2    6.4e-08   32.6   0.1    3.3  3  Vault_4       Major Vault Protein repeat domain
      5e-08   33.0   0.3    6.6e-07   29.4   0.0    3.1  5  Vault         Major Vault Protein repeat domain
     0.0072   16.6   0.5      0.019   15.3   0.5    1.6  1  Lipocalin_9   Lipocalin-like domain


Domain annotation for each model (and alignments):
>> MVP_shoulder  Shoulder domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  114.4   0.2   7.8e-37   2.8e-33       1     118 []     269     388 ..     269     388 .. 0.89
   2 ?   -1.4   0.0      0.62   2.2e+03       9      27 ..     444     462 ..     428     490 .. 0.68

  Alignments for each domain:
  == domain 1  score: 114.4 bits;  conditional E-value: 7.8e-37
                   SSEEEEECEEEE-TTSEEEEEEEGGCEEE---SSHHHHHHCCCHSSHHHHHHHHHHHHHHHHHHTTSHHHHHHHHHHHHHHHHHSGSB---EE.... CS
  MVP_shoulder   1 gPdfvtDvievetadharLqlklsynweFevdkkdeeeaeklFsvedfvgdackalasriRgavasvtfdeFhknsakiireavfgvdeegkv.... 93 
                   gPdfv+D+++v+t+d+a+L++ l+y+weF v   de++++ +F++ df+g++c +l+sr+R+ +a +tf+eFh+ ++++ir+++f+ ++  +v    
    EFC37269.1 269 GPDFVSDSFRVSTKDNAELSILLTYKWEFLV---DESDSHVMFRMLDFIGYICATLMSRVRELAALFTFEEFHSGTVSLIRKHLFNESK-VNVgnee 361
                   8****************************88...57788889*******************************************9443.3334444 PP

                   ..SS-EEETTTTEEEEE--EEEECCSH CS
  MVP_shoulder  94 ..rkellfeennlvitsvdvqsvepvd 118
                       +++f+e++l+++++dv+s++pv+
    EFC37269.1 362 ksVLGIYFDEIKLLVSEIDVKSISPVN 388
                   335679*******************96 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.62
                   EEEE-TTSEEEEEEEGGCE CS
  MVP_shoulder   9 ievetadharLqlklsynw 27 
                   ++ve  + a+++ +++y+ 
    EFC37269.1 444 LQVEKVEEAKIDSQVTYET 462
                   5566666666666666653 PP

>> Vault_3  Major Vault Protein Repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0   0.00037       1.3       8      39 ..       6      37 ..       1      45 [. 0.89
   2 ?    1.8   0.0     0.069   2.5e+02      20      40 ..      68      88 ..      57      93 .. 0.78
   3 !    8.3   0.0   0.00065       2.3       6      39 ..     152     185 ..     147     187 .. 0.91
   4 !   35.3   0.0   2.4e-12   8.6e-09      12      57 ..     219     263 ..     210     267 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00037
     Vault_3  8 hNaavqiydyktkksRvvfGPelViLePhEef 39
                 N+ v i d  +   ++++GP+ + L  +E +
  EFC37269.1  6 PNTYVHILDNDSGVVKIEIGPKRIALRANEAI 37
                69**************************9986 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.069
     Vault_3 20 kksRvvfGPelViLePhEeft 40
                 + Rv+ GP+   L  +E + 
  EFC37269.1 68 GERRVIEGPKALALHRNEVIE 88
                467***********9999775 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00065
     Vault_3   6 vphNaavqiydyktkksRvvfGPelViLePhEef 39 
                 ++ N ++ + d+ t ++++v GP+  iL+  Ee+
  EFC37269.1 152 INENEGIYVQDTETSEKKLVKGPACYILKATEEL 185
                 78899***********************999986 PP

  == domain 4  score: 35.3 bits;  conditional E-value: 2.4e-12
     Vault_3  12 vqiydyktkksRvvfGPelViLePhEeftvlsLSgGkPKepnaiks 57 
                 v + d  +++ R++ GP+  iL P+E++  l LS+GkPK+ ++ik+
  EFC37269.1 219 VCVLDA-ERNERIINGPTSYILSPEEHVKCLWLSAGKPKQIKQIKA 263
                 555565.4568*********************************97 PP

>> Vault_4  Major Vault Protein repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.21   7.5e+02       7      34 ..       7      35 ..       3      40 .. 0.76
   2 !   32.6   0.1   1.8e-11   6.4e-08       1      40 [.     149     189 ..     149     198 .. 0.93
   3 ?   -1.0   0.0      0.54   1.9e+03      21      35 ..     229     244 ..     223     253 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.21
     Vault_4  7 nEGiYvRdiktGkvrvviG.etYmlteeE 34
                n  + + d  +G v+++iG +   l+ +E
  EFC37269.1  7 NTYVHILDNDSGVVKIEIGpKRIALRANE 35
                5567788999********96666677776 PP

  == domain 2  score: 32.6 bits;  conditional E-value: 1.8e-11
     Vault_4   1 AipLdenEGiYvRdiktGkvrvviG.etYmlteeEelWeKe 40 
                 Ai ++enEGiYv d++t + ++v G   Y+l+  Eel+ K+
  EFC37269.1 149 AIMINENEGIYVQDTETSEKKLVKGpACYILKATEELYYKQ 189
                 8999*********************899**********997 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.54
     Vault_4  21 rvviG.etYmlteeEe 35 
                 r++ G ++Y+l +eE 
  EFC37269.1 229 RIINGpTSYILSPEEH 244
                 56778899****9996 PP

>> Vault  Major Vault Protein repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0         1   3.7e+03      10      22 ..      30      42 ..      29      77 .. 0.65
   2 !   29.4   0.0   1.8e-10   6.6e-07       1      42 []      94     138 ..      94     138 .. 0.89
   3 ?   -3.2   0.0       2.8   9.9e+03       4      14 ..     153     163 ..     152     173 .. 0.78
   4 ?   -2.1   0.0       1.3   4.7e+03      32      40 ..     170     178 ..     165     180 .. 0.91
   5 ?   -4.2   0.0         5   1.8e+04      33      40 ..     231     238 ..     231     238 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1
       Vault 10 lLrAledFtddng 22
                 LrA+e+   +++
  EFC37269.1 30 ALRANEAIINTQN 42
                5777776655544 PP

  == domain 2  score: 29.4 bits;  conditional E-value: 1.8e-10
       Vault   1 yvLseneALlLrAledFtddng...vkRkaGdrWlvrGPgeYiPp 42 
                 ++L++n+AL+Lr+l d + ++    v  kaGd + ++GP  +iP+
  EFC37269.1  94 HILKPNQALRLRCLVDKKIEIDgkeVDLKAGDVYQIKGPARFIPD 138
                 79*************8887633366*******************5 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.8
       Vault   4 seneALlLrAl 14 
                  ene++ ++ +
  EFC37269.1 153 NENEGIYVQDT 163
                 68999999855 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 1.3
       Vault  32 lvrGPgeYi 40 
                 lv+GP  Yi
  EFC37269.1 170 LVKGPACYI 178
                 89******9 PP

  == domain 5  score: -4.2 bits;  conditional E-value: 5
       Vault  33 vrGPgeYi 40 
                 + GP  Yi
  EFC37269.1 231 INGPTSYI 238
                 579****9 PP

>> Lipocalin_9  Lipocalin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.5   5.2e-06     0.019      39     128 ..     419     504 ..     393     505 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 5.2e-06
                  .EEEE-TTS-EEEE-GGGEEEEEEEEEE-TTT--EEEE....EEEETTEEEEEEES-S--EEET--EEEEEEEEETT...EEEEEEEEEE CS
  Lipocalin_9  39 sgtliaadgeatalskediklepletwtspktgakyPvkwqvelpseeldltvepllkdqeldttipYWEGavkvegsgsvnGrGYlElt 128
                  +    +a++e ++l +e i +e  + +  + ++ak+ ++  v+ ++++ +++v+  +k    +  ++Y  G +++   ++++Gr Y+El+
   EFC37269.1 419 QKEQLKAEAEIQKLREELIGIENENLQVEKVEEAKIDSQ--VTYETTKANIEVQNYIKSTDAQIELSYMKGMIEL--LSTEQGRKYMELK 504
                  245678999999999999999999988878888888885..555556889*************9***********..66799******96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (530 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1744  (0.0972726); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.54
# Mc/sec: 2964.09
//
Query:       EFC37270.1  [L=327]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    7.5e-18   63.5  14.4    6.5e-06   25.7   0.7    5.8  6  TPR_1       Tetratricopeptide repeat
    6.7e-15   53.9  10.5    1.1e-05   25.2   0.2    5.6  6  TPR_2       Tetratricopeptide repeat
    1.1e-09   38.8   0.0    2.2e-08   34.6   0.0    2.5  2  TPR_16      Tetratricopeptide repeat
    2.2e-09   36.8   6.4    2.3e-05   24.0   0.4    4.0  4  TPR_11      TPR repeat
    8.2e-09   35.0   7.1      0.011   15.9   0.7    5.3  5  TPR_8       Tetratricopeptide repeat
    9.2e-08   32.3   3.2      0.034   14.8   0.0    4.7  4  TPR_6       Tetratricopeptide repeat
    1.5e-07   31.3   6.4    0.00012   22.2   0.2    4.0  4  TPR_17      Tetratricopeptide repeat
    6.8e-07   29.3   0.0    0.00013   22.1   0.0    2.4  2  TPR_9       Tetratricopeptide repeat
    0.00036   20.8   0.2        1.6    9.0   0.1    4.1  4  TPR_12      Tetratricopeptide repeat
    0.00049   20.7   0.0        4.4    8.4   0.0    3.5  4  TPR_14      Tetratricopeptide repeat
    0.00051   20.5   0.0      0.006   17.1   0.0    2.6  3  TPR_19      Tetratricopeptide repeat
    0.00053   20.2   2.5      0.035   14.3   1.5    2.5  2  ANAPC3      Anaphase-promoting complex, cyclosome, subunit 3
  ------ inclusion threshold ------
      0.023   14.7   1.9        2.3    8.3   0.5    2.7  3  Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.2   0.00038      0.52      12      29 ..      88     105 ..      88     106 .. 0.94
   2 ?    3.0   0.0     0.074     1e+02      22      32 ..     143     153 ..     139     155 .. 0.86
   3 !   25.3   0.0   6.4e-09   8.9e-06       2      34 .]     157     189 ..     156     189 .. 0.95
   4 !   25.7   0.7   4.7e-09   6.5e-06       2      34 .]     191     223 ..     190     223 .. 0.94
   5 ?   -1.5   0.0       1.9   2.7e+03       2      13 ..     225     236 ..     224     237 .. 0.81
   6 ?    5.0   0.0     0.017        23       6      25 ..     276     295 ..     273     297 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00038
                 HHTT-HHHHHHHHHHHHH CS
       TPR_1  12 fklgkydeAleyyekALe 29 
                 ++++ky+eA e++ k++e
  EFC37270.1  88 YNQKKYKEATEFFTKVIE 105
                 68**************98 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.074
                 HHHHHHHHHST CS
       TPR_1  22 eyyekALelnP 32 
                 ++ +kA e+nP
  EFC37270.1 143 QDLQKAKEINP 153
                 799******** PP

  == domain 3  score: 25.3 bits;  conditional E-value: 6.4e-09
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                 +++y++Gn+++   +y  A+++y+kA+   P++
  EFC37270.1 157 EVFYRRGNLFYFDSNYSSAIKDYSKAIANHPDF 189
                 799*************************99996 PP

  == domain 4  score: 25.7 bits;  conditional E-value: 4.7e-09
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                 ++++n+G++y++l+++d ++++ e  L++ Pn+
  EFC37270.1 191 ECYFNRGLCYYQLKRLDRCIKDLETYLKHVPND 223
                 79***********************99999986 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 1.9
                 HHHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfk 13 
                 ++l+ lG  y++
  EFC37270.1 225 NTLKLLGISYYY 236
                 578999**9996 PP

  == domain 6  score: 5.0 bits;  conditional E-value: 0.017
                 HHHHHHHHTT-HHHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyye 25 
                  +G  +++l+++d A ++++
  EFC37270.1 276 IRGSSLRELKQLDLAQQDFQ 295
                 5899***************8 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.1    0.0012       1.7      12      29 ..      88     105 ..      88     109 .. 0.92
   2 ?   -0.4   0.0       1.2   1.7e+03      23      32 ..     144     153 ..     141     155 .. 0.81
   3 !   17.6   0.0   2.1e-06    0.0029       1      33 [.     156     188 ..     156     189 .. 0.94
   4 !   25.2   0.2   7.6e-09   1.1e-05       2      34 .]     191     223 ..     190     223 .. 0.96
   5 ?   -1.2   0.0       2.2     3e+03       3      13 ..     226     236 ..     224     237 .. 0.80
   6 ?    4.1   0.1     0.044        60       4      26 ..     274     296 ..     272     297 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0012
       TPR_2  12 yklgdyeeAleafekAle 29 
                 y++++y+eA e+f k++e
  EFC37270.1  88 YNQKKYKEATEFFTKVIE 105
                 89*************998 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.2
       TPR_2  23 afekAleldP 32 
                 +++kA e++P
  EFC37270.1 144 DLQKAKEINP 153
                 7899999999 PP

  == domain 3  score: 17.6 bits;  conditional E-value: 2.1e-06
       TPR_2   1 aealynlGlayyklgdyeeAleafekAleldPn 33 
                 +e+ y++G++ y   +y  A++++ kA++  P+
  EFC37270.1 156 PEVFYRRGNLFYFDSNYSSAIKDYSKAIANHPD 188
                 6899************************99997 PP

  == domain 4  score: 25.2 bits;  conditional E-value: 7.6e-09
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                 e+++n+Gl+yy+l++++++++++e  l++ Pn+
  EFC37270.1 191 ECYFNRGLCYYQLKRLDRCIKDLETYLKHVPND 223
                 79*****************************97 PP

  == domain 5  score: -1.2 bits;  conditional E-value: 2.2
       TPR_2   3 alynlGlayyk 13 
                  l  lG +yy+
  EFC37270.1 226 TLKLLGISYYY 236
                 57789****97 PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.044
       TPR_2   4 lynlGlayyklgdyeeAleafek 26 
                 +  +G ++++l++++ A ++f++
  EFC37270.1 274 YLIRGSSLRELKQLDLAQQDFQA 296
                 56699***************985 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.6   0.0   1.6e-11   2.2e-08       1      68 []     160     224 ..     160     224 .. 0.96
   2 ?    1.3   0.0      0.41   5.7e+02      15      53 ..     253     290 ..     250     297 .. 0.80

  Alignments for each domain:
  == domain 1  score: 34.6 bits;  conditional E-value: 1.6e-11
      TPR_16   1 lalaraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapdap 68 
                 + ++++++   +y  A++ +  a++++   Pd +e ++++g+++++++rl++ +  ++ +l++ p++p
  EFC37270.1 160 YRRGNLFYFDSNYSSAIKDYSKAIANH---PDFYECYFNRGLCYYQLKRLDRCIKDLETYLKHVPNDP 224
                 6799***********************...************************99999999999998 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.41
      TPR_16  15 dAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeA 53 
                 +A+  +  ++k++ s P++ e +l +g ++ +++ l++A
  EFC37270.1 253 EALTSYINYRKQN-SLPLTKEDYLIRGSSLRELKQLDLA 290
                 6888888888888.8888888899999999999999988 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       2.8   3.8e+03      16      22 ..      92      98 ..      88      99 .. 0.59
   2 !   12.0   0.0   9.1e-05      0.13       6      39 ..     134     167 ..     131     168 .. 0.89
   3 !   24.0   0.4   1.7e-08   2.3e-05       9      41 ..     171     203 ..     169     204 .. 0.96
   4 !    5.8   0.3    0.0078        11       4      39 ..     200     235 ..     200     236 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.8
      TPR_11 16 aYkkAlk 22
                +Yk+A +
  EFC37270.1 92 KYKEATE 98
                5666654 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 9.1e-05
      TPR_11   6 eqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                  +G ++++ ++++kA +++P  +e++y +G+++y
  EFC37270.1 134 YRGVITNSYQDLQKAKEINPFHPEVFYRRGNLFY 167
                 56777888899*********************98 PP

  == domain 3  score: 24.0 bits;  conditional E-value: 1.7e-08
      TPR_11   9 kyeeAieaYkkAlkldPdnaeayynLGlayykq 41 
                 +y  Ai++Y+kA++  Pd+ e y+n+Gl yy++
  EFC37270.1 171 NYSSAIKDYSKAIANHPDFYECYFNRGLCYYQL 203
                 6999***************************97 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0078
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 yy++ +++  i+++++ lk  P++++ +  LG  yy
  EFC37270.1 200 YYQLKRLDRCIKDLETYLKHVPNDPNTLKLLGISYY 235
                 9********************************998 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.2     0.022        30      13      29 ..      89     105 ..      88     105 .. 0.92
   2 ?    1.0   0.0      0.47   6.5e+02      19      33 ..     140     154 ..     136     155 .. 0.82
   3 !    7.1   0.0    0.0052       7.1       2      28 ..     157     183 ..     156     188 .. 0.91
   4 !   15.9   0.7     8e-06     0.011       2      29 ..     191     218 ..     190     218 .. 0.94
   5 ?    4.5   0.0     0.036        50       4      25 ..     274     295 ..     274     299 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.022
                 HTT-HHHHHHHHHHHHH CS
       TPR_8  13 klgdyeeAkeyyekale 29 
                 ++++y+eA e++ k++e
  EFC37270.1  89 NQKKYKEATEFFTKVIE 105
                 689***********997 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.47
                 HHHHHHHHHHHHHHH CS
       TPR_8  19 eAkeyyekaleldpd 33 
                 ++ + ++ka e++p 
  EFC37270.1 140 NSYQDLQKAKEINPF 154
                 5668899*****997 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0052
                 CHHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekal 28 
                 e+ y+ g++     +y +A++ y ka+
  EFC37270.1 157 EVFYRRGNLFYFDSNYSSAIKDYSKAI 183
                 78999*********************9 PP

  == domain 4  score: 15.9 bits;  conditional E-value: 8e-06
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekale 29 
                 e y+n g++y +l++++  ++ +e +l+
  EFC37270.1 191 ECYFNRGLCYYQLKRLDRCIKDLETYLK 218
                 89**********************9886 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.036
                 HHHHHHHHHHTT-HHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyye 25 
                 y+  gs +++l++++ A++ ++
  EFC37270.1 274 YLIRGSSLRELKQLDLAQQDFQ 295
                 67789**************997 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1      0.45   6.2e+02      11      29 ..      88     106 ..      88     106 .. 0.89
   2 !   10.4   0.0   0.00063      0.87       1      32 [.     157     188 ..     157     188 .. 0.92
   3 !   14.8   0.0   2.5e-05     0.034       1      32 [.     191     222 ..     191     223 .. 0.93
   4 ?    2.2   0.2      0.26   3.6e+02       4      24 ..     275     295 ..     274     296 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.45
                 HHHHHHHHHHHHHHHHHHH CS
       TPR_6  11 rklgdtdkAlealerlike 29 
                 ++++++ +A e + ++i++
  EFC37270.1  88 YNQKKYKEATEFFTKVIEK 106
                 56889***********986 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00063
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   1 dAlyklalsyrklgdtdkAlealerlikeYPd 32 
                 +++y+++ +++   +++ A++ + + i ++Pd
  EFC37270.1 157 EVFYRRGNLFYFDSNYSSAIKDYSKAIANHPD 188
                 679****9999955*****************8 PP

  == domain 3  score: 14.8 bits;  conditional E-value: 2.5e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   1 dAlyklalsyrklgdtdkAlealerlikeYPd 32 
                 +++++++l+y++l++ d+ ++ le  +k  P+
  EFC37270.1 191 ECYFNRGLCYYQLKRLDRCIKDLETYLKHVPN 222
                 679***********************998887 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.26
                 HHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   4 yklalsyrklgdtdkAleale 24 
                 + ++ s+r+l++ d A + ++
  EFC37270.1 275 LIRGSSLRELKQLDLAQQDFQ 295
                 67899****99******9998 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0    0.0029         4       3      33 ..     146     176 ..     144     177 .. 0.84
   2 !   22.2   0.2   8.7e-08   0.00012       2      34 .]     179     211 ..     178     211 .. 0.95
   3 ?    1.6   0.1      0.33   4.6e+02       3      24 ..     214     235 ..     213     246 .. 0.84
   4 ?   -1.1   0.1       2.4   3.4e+03      19      34 .]     277     292 ..     274     292 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0029
      TPR_17   3 lkaleldPnnadaynnLAelllknGdlmtAr 33 
                 +ka e++P ++++++ +++l++   ++  A+
  EFC37270.1 146 QKAKEINPFHPEVFYRRGNLFYFDSNYSSAI 176
                 566699**************99888877665 PP

  == domain 2  score: 22.2 bits;  conditional E-value: 8.7e-08
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlmtArq 34 
                 y ka++++P+  + y+n++ +++++++l+++++
  EFC37270.1 179 YSKAIANHPDFYECYFNRGLCYYQLKRLDRCIK 211
                 88****************************985 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.33
      TPR_17   3 lkaleldPnnadaynnLAelll 24 
                 +  l++ Pn+++ + +L+  ++
  EFC37270.1 214 ETYLKHVPNDPNTLKLLGISYY 235
                 5678999******999998775 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 2.4
      TPR_17  19 LAelllknGdlmtArq 34 
                 ++  l+++++l+ A+q
  EFC37270.1 277 RGSSLRELKQLDLAQQ 292
                 67789999******98 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0     0.012        17      24      61 ..     151     188 ..     143     189 .. 0.92
   2 !   22.1   0.0   9.2e-08   0.00013      26      64 ..     187     225 ..     186     230 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.012
       TPR_9  24 laPddpeerrdRGlllaqlGclsaAladLeaylalapd 61 
                 ++P +pe  + RG l +   ++s A++d   ++a+ pd
  EFC37270.1 151 INPFHPEVFYRRGNLFYFDSNYSSAIKDYSKAIANHPD 188
                 78999999**************************9997 PP

  == domain 2  score: 22.1 bits;  conditional E-value: 9.2e-08
       TPR_9  26 PddpeerrdRGlllaqlGclsaAladLeaylalapdapd 64 
                 Pd  e ++ RGl+++ql +l   ++dLe+yl + p++p 
  EFC37270.1 187 PDFYECYFNRGLCYYQLKRLDRCIKDLETYLKHVPNDPN 225
                 666677899**************************9986 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.048        67      31      73 ..      64     105 ..      62     109 .. 0.76
   2 !    9.0   0.1    0.0012       1.6       8      67 ..     161     212 ..     155     222 .. 0.72
   3 !    7.3   0.0    0.0042       5.8       8      43 ..     195     225 ..     188     237 .. 0.72
   4 ?    1.0   0.1      0.37   5.1e+02       9      27 ..     277     295 ..     272     299 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.048
      TPR_12  31 eiarrllGpdhpltattlrnLgrlyralgryeeAlelleeala 73 
                 +i+++++  +h++t  + +   + y +  +y+eA e+++++++
  EFC37270.1  64 DIHEKVFSNQHLYTTKIFHVAVDGYNQK-KYKEATEFFTKVIE 105
                 5777788888888888888888887555.88888888888765 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0012
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlel 67 
                 +++++ +   +y  A++ + ka+         +hp+  ++++n g +y++l+r++  ++ 
  EFC37270.1 161 RRGNLFYFDSNYSSAIKDYSKAI--------ANHPDFYECYFNRGLCYYQLKRLDRCIKD 212
                 67777777788888888888883........45555667999999999999998865555 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0042
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpl 43 
                 n+++++++l+r+d +++ le+ l  +     p+ p+
  EFC37270.1 195 NRGLCYYQLKRLDRCIKDLETYLKHV-----PNDPN 225
                 78888888888888888888766666.....55555 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.37
      TPR_12   9 laavlrrlgrydeAlelle 27 
                 +++ lr+l+++d A++ ++
  EFC37270.1 277 RGSSLRELKQLDLAQQDFQ 295
                 5788999999999998887 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0         9   1.2e+04      14      32 ..      90     108 ..      88     112 .. 0.80
   2 !    8.0   0.0    0.0043         6       1      39 [.     156     194 ..     156     199 .. 0.88
   3 !    8.4   0.0    0.0032       4.4       8      42 ..     197     231 ..     191     232 .. 0.88
   4 ?   -0.4   0.1       2.1   2.9e+03       4      25 ..     274     295 ..     272     298 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 9
      TPR_14  14 lGdpdeAiallrralalaP 32 
                 + +++eA + + ++++++ 
  EFC37270.1  90 QKKYKEATEFFTKVIEKGK 108
                 6789999999999998865 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0043
      TPR_14   1 peallalaeallalGdpdeAiallrralalaPddaeawl 39 
                 pe+ ++++ +++   ++  Ai+ + +a+a +Pd+ e ++
  EFC37270.1 156 PEVFYRRGNLFYFDSNYSSAIKDYSKAIANHPDFYECYF 194
                 678899999999999******************987665 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0032
      TPR_14   8 aeallalGdpdeAiallrralalaPddaeawllla 42 
                 +  +++l ++d+ i+ l+ +l++ P+d+ ++ ll+
  EFC37270.1 197 GLCYYQLKRLDRCIKDLETYLKHVPNDPNTLKLLG 231
                 566899**********************9988876 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 2.1
      TPR_14   4 llalaeallalGdpdeAiallr 25 
                 +l +++ l++l ++d A + ++
  EFC37270.1 274 YLIRGSSLRELKQLDLAQQDFQ 295
                 6778888888999888877665 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       1.4   1.9e+03       4      19 ..      90     105 ..      88     110 .. 0.80
   2 ?   -2.6   0.0       5.9   8.2e+03      14      30 ..     145     161 ..     139     167 .. 0.70
   3 !   17.1   0.0   4.4e-06     0.006       6      62 ..     171     227 ..     169     232 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.4
      TPR_19   4 egdyaeAlalleqalq 19 
                 +++y eA ++++++++
  EFC37270.1  90 QKKYKEATEFFTKVIE 105
                 7789999999998865 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 5.9
      TPR_19  14 leqalqedpknaearll 30 
                 l++a + +p ++e+ ++
  EFC37270.1 145 LQKAKEINPFHPEVFYR 161
                 66777777777777775 PP

  == domain 3  score: 17.1 bits;  conditional E-value: 4.4e-06
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddarya 62 
                 +y +A++ +++a++  p+  e   +   ++++l++ld  ++ L++++++ p+d++  
  EFC37270.1 171 NYSSAIKDYSKAIANHPDFYECYFNRGLCYYQLKRLDRCIKDLETYLKHVPNDPNTL 227
                 7999************************************************98755 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.038        52      30      49 ..      84     103 ..      65     113 .. 0.74
   2 !   14.3   1.5   2.6e-05     0.035       4      67 ..     171     235 ..     169     250 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.038
                 HHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  30 AlclylngqykrAyellrka 49 
                 A   y++++yk+A e++ k 
  EFC37270.1  84 AVDGYNQKKYKEATEFFTKV 103
                 66679999999999999887 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 2.6e-05
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHH CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcll 67 
                 ny +Ai  ++++ a +++ +e  +  +lc+y++++ +r+++ l+++ k  +++++ + l++ +++
  EFC37270.1 171 NYSSAIKDYSKAIANHPDFYECYFNRGLCYYQLKRLDRCIKDLETYlKHVPNDPNTLKLLGISYY 235
                 89999999*****6666666666667********************9999999999999998776 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.022        31       3      28 ..      79     104 ..      77     108 .. 0.86
   2 ?   -3.1   0.0       6.5     9e+03      14      20 ..     176     182 ..     171     188 .. 0.73
   3 ?    8.3   0.5    0.0017       2.3       2      40 ..     191     229 ..     190     232 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.022
                 HHHHHHHHHHHHT-HHHHHHHHHHHH CS
  Fis1_TPR_C   3 clYylAlGhyklgeYseArryvdalL 28 
                 +++++A+  y +++Y+eA ++   ++
  EFC37270.1  79 KIFHVAVDGYNQKKYKEATEFFTKVI 104
                 589999999**********9987666 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 6.5
                 HT-HHHH CS
  Fis1_TPR_C  14 lgeYseA 20 
                 +++Ys+A
  EFC37270.1 176 IKDYSKA 182
                 5677776 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0017
                 HHHHHHHHHHHHHT-HHHHHHHHHHHHHHTTS-HHHHHH CS
  Fis1_TPR_C   2 eclYylAlGhyklgeYseArryvdalLeiEPenrQaqsL 40 
                 ec +   l +y l++ +++ + +++ L++ P+  + ++L
  EFC37270.1 191 ECYFNRGLCYYQLKRLDRCIKDLETYLKHVPNDPNTLKL 229
                 89*****************************99888777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (327 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       861  (0.0480228); expected 358.6 (0.02)
Passed bias filter:                      543  (0.0302861); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1970.56
//
Query:       EFC37271.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.5e-17   61.1  18.2      1e-16   60.9  18.2    1.1  1  Far-17a_AIG1  FAR-17a/AIG1-like protein
  ------ inclusion threshold ------
        0.2   11.7   0.1       0.45   10.6   0.1    1.5  1  COA2          Cytochrome C oxidase assembly factor 2


Domain annotation for each model (and alignments):
>> Far-17a_AIG1  FAR-17a/AIG1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.9  18.2   1.1e-20     1e-16       2     194 ..       6     200 ..       5     212 .. 0.84

  Alignments for each domain:
  == domain 1  score: 60.9 bits;  conditional E-value: 1.1e-20
  Far-17a_AIG1   2 sllvhlstlcsyaalfypfhsekelaneaayGgkfkyLtfiglvlqalfftlallaD......eltlsallklrdnllavlafPvevlvsvlFWgLy 92 
                   +ll+h+++++s  a fy +h    l          k  t++  ++q+++f+l+ll+       + + s  + l d+ + +l   +++  + lFW++y
    EFC37271.1   6 TLLFHFVAISSQLAAFYWMHLIGILS----LSMILKMFTLWTGCVQVIYFGLSLLEGlfggntKNQRSSNSILNDLFHLTLL--MALATVSLFWSIY 96 
                   68999999999999999999976666....55899********************99****877777777778888877777..9999********* PP

  Far-17a_AIG1  93 liDrelvypklldelipdWlnhsmHtvvlvailleifllkhkyp....srlaalalsaafallYliwiervaqfngvwvYPvlealslegrvlffal 185
                   + D+e + pk   + +pd lnh  Htv+ +++l+e++l + +        ++ + ++  + ++Yl      ++++g+w+YP++++ s+  + +f ++
    EFC37271.1  97 WLDPENMVPKG--MYYPDGLNHLHHTVPGILVLIELILVRSTSDvlhgIWKRKFYMVLCIPVAYLSFTGLSKHMKGYWPYPFMASWSFLEFGIFCVF 191
                   **********7..88*************************99998877555666667789999************************9988877666 PP

  Far-17a_AIG1 186 savvmally 194
                   +++++ +l 
    EFC37271.1 192 AVILASILH 200
                   665554432 PP

>> COA2  Cytochrome C oxidase assembly factor 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1     5e-05      0.45       9      31 ..      69      91 ..      63      96 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 5e-05
        COA2  9 qkrklvnllfgttaliatatvii 31
                  ++++n lf  t l+a+atv +
  EFC37271.1 69 SSNSILNDLFHLTLLMALATVSL 91
                4699****************964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       689  (0.0384294); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.31s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 1460.22
//
Query:       EFC37272.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-14   53.1   0.0    3.8e-14   53.1   0.0    2.2  2  Band_7    SPFH domain / Band 7 family


Domain annotation for each model (and alignments):
>> Band_7  SPFH domain / Band 7 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.1   0.0   2.1e-18   3.8e-14       3     177 ..      76     260 ..      74     261 .. 0.85
   2 ?   -0.4   3.2     0.058     1e+03     118     172 ..     324     379 ..     294     389 .. 0.76

  Alignments for each domain:
  == domain 1  score: 53.1 bits;  conditional E-value: 2.1e-18
      Band_7   3 ieegevgvvvrfGklsr.vlepGlhfilPfgrsvtvvsvrvqtldvsvsltvptkDglpvtidvtviyrv.....pddapklvaav....eresanldn 91 
                  ++++++v+++ G  +  v +  + +  P +++++ v++   t++++    +++k++++++++vt+++        +    +++ +    e +++++++
  EFC37272.1  76 CQPNQYLVRTGIGITNMsVSKKAVVW--P-LQKHVYVNMNPKTYTFNL--HNMSKEKVEFNLPVTFTIGPidpntDKGMEGFIKYCqkitEATPKEIET 169
                 57788888877777777677777666..7.777777************..******************88788874444444444466699999***** PP

      Band_7  92 lirrvlesalrevisemtleellsnreelaeelknelneqlrkyGvevldvritdidpppevaqalaakqaaeaea.....qaeiaraeae 177
                 li  ++e+++r +++++t+ee+++++e ++ee+ + + ++l+ +G+++ +++i++ +  +e  + ++ +++  +e+     qa +++a++e
  EFC37272.1 170 LIAGIIEGETRGLTAKLTVEEMFNSKERFKEEVVASIEKDLNLLGLTIFNANIKEMSDYDERNKYFEYRKQIAIEKanyqsQADVSEAKKE 260
                 ********************************************************99999999988777777777699999999999987 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.058
      Band_7 118 eelaeelknelneqlrkyGvevldvr.itdidpppevaqalaakqaaeaeaqaeia 172
                  e ++el++ +n +l+++ +e+++   +++    +e ++++a++    ++++ae+ 
  EFC37272.1 324 KERQAELQRSVNTKLKEQQLEFMRSEsLSKAIVDAEAQERMADAHFYSERKKAEAI 379
                 56789999999999999999999766688888899999987776655555544443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1673  (0.0933125); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 3330.26
//
Query:       EFC37273.1  [L=382]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-06   27.6   0.0    8.4e-06   26.1   0.0    1.7  1  AAA_22    AAA domain
    1.9e-05   24.7   0.0    4.6e-05   23.4   0.0    1.7  1  AAA_5     AAA domain (dynein-related subfamily)
    4.9e-05   23.8   0.3      0.014   15.7   0.3    2.5  1  AAA_16    AAA ATPase domain
    6.5e-05   23.1   0.0    0.00013   22.2   0.0    1.4  1  AAA_33    AAA domain
    0.00042   20.1   0.1     0.0016   18.2   0.1    1.9  1  AAA_24    AAA domain
     0.0038   17.6   0.1      0.019   15.4   0.0    2.2  2  AAA       ATPase family associated with various cellular acti
  ------ inclusion threshold ------
      0.013   14.7   0.0      0.027   13.7   0.0    1.5  1  NB-ARC    NB-ARC domain
      0.019   14.5   0.0      0.033   13.7   0.0    1.4  1  AAA_7     P-loop containing dynein motor region
      0.097   12.6   4.0       0.49   10.3   0.7    2.9  2  ATPase_2  ATPase domain predominantly from Archaea


Domain annotation for each model (and alignments):
>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   0.0   4.2e-09   8.4e-06      11     116 ..     113     208 ..     111     227 .. 0.78

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 4.2e-09
      AAA_22  11 tGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdllrellralglelkaerlsseellealeqalrarav..ielliiDEaqhlrsee 107
                 +GesG+GKTt l++ l+ l+        + ++++v l++ t+ k+l++ +   +++e+   + + +  ++++   +++ ++   ++liiD+a +    +
  EFC37273.1 113 YGESGIGKTTMLKESLRLLE--------PFPYLLVSLSKTTTIKELAKLMNLVVDDEAR--WSDIQLAINQFIALAHQNQKgqCPILIIDNANRN--RK 199
                 7******************7........******************7777666665444..47777777999999998888999********997..34 PP

      AAA_22 108 aleeLrsll 116
                 + e++ +++
  EFC37273.1 200 ITEQFIDMV 208
                 444444444 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.0   2.3e-08   4.6e-05       5      60 ..     113     170 ..     112     215 .. 0.82

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 2.3e-08
                 E--SSSSHHHHHHHGGGGB.S--EEEEE--TT--HHHHH--B--..........---- CS
       AAA_5   5 vGppGtgKselaerlaaal.nreveyvqltrdtteedlkgrreik.ngttslvdsplv 60 
                  G++G+gK+++ ++ +++l   +++ v l++ tt ++l   +++  +++++++d  l 
  EFC37273.1 113 YGESGIGKTTMLKESLRLLePFPYLLVSLSKTTTIKELAKLMNLVvDDEARWSDIQLA 170
                 6******************************************999******998886 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.3   7.2e-06     0.014      25     170 .]     108     221 ..      88     221 .. 0.61

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 7.2e-06
      AAA_16  25 elvllsGesGvGKsslvrellralekd..ggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawrekleealaavpelagaeasrlle 121
                 ++  ++GesG+GK+++++e lr l +   + ++   k++            +++   +l++ + d+      ++w+                   ++  
  EFC37273.1 108 SMRGFYGESGIGKTTMLKESLR-LLEPfpYLLVSLSKTTTI---------KELA---KLMNLVVDD-----EARWS-------------------DIQL 169
                 555579*************996.444412222222222222.........1222...344444444.....34444...................4777 PP

      AAA_16 122 llkrllallsrderp..lvlvlDdlqwadeaslqllaaLlrllesk.pllvv 170
                 ++++++al++++++    +l++D++ + +  + q+++   +++e++  ll+v
  EFC37273.1 170 AINQFIALAHQNQKGqcPILIIDNANRNRKITEQFIDMVRENTERQvGLLIV 221
                 7888888888877767788888888888888888888777777776677665 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.0   6.5e-08   0.00013       4      95 ..     112     211 ..     111     223 .. 0.75

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 6.5e-08
      AAA_33   4 lvGlpGsGKstlaerllkklg.....avllssdtlrrrlfg...tdqqsktdytrvldrlyqilnelarkalsagrn.vildatnlsrrerarflklar 93 
                 + G +G GK+t +++ l+ l       v ls+ t ++ l++     ++++ +++++   ++q++ +la+++++  ++ +i+d+ n++r+  ++f+ ++r
  EFC37273.1 112 FYGESGIGKTTMLKESLRLLEpfpylLVSLSKTTTIKELAKlmnLVVDDEARWSDIQLAINQFI-ALAHQNQKGQCPiLIIDNANRNRKITEQFIDMVR 209
                 5799**********98777777775555566666666555544255556655566555566666.************8888********9999999998 PP

      AAA_33  94 rl 95 
                 + 
  EFC37273.1 210 EN 211
                 64 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.1     8e-07    0.0016       8      91 ..     113     211 ..     109     229 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 8e-07
      AAA_24   8 yGpsgiGKTtlakel.....gpkplfidtekGlksldadkfpdie.....swedfldevvel.....aaeladyktlviDtideleelclaevirqnek 91 
                 yG+sgiGKTt++ke      +   l++ + k +   + +k+ ++       w d+  +++++     + ++ ++ +l+iD+++   +++ + ++   e+
  EFC37273.1 113 YGESGIGKTTMLKESlrllePFPYLLVSLSKTTTIKELAKLMNLVvddeaRWSDIQLAINQFialahQNQKGQCPILIIDNANRNRKITEQFIDMVREN 211
                 9**************9998655556667777666666666666556677777777777777788899899999**********9977666555544444 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   9.7e-06     0.019       3      70 ..     112     197 ..     111     224 .. 0.80
   2 ?   -3.0   0.0       4.5   8.9e+03      26      45 ..     320     348 ..     300     368 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 9.7e-06
                 EESSTTSSHHHHHHHHHHHHT.HEEEEEETTTCS.SS..............STTHHHHHHHHHHHHHHHTS..TSEEEEEETGGGH CS
         AAA   3 lyGppGtGKTllakavakelg.vefleisgsell.sk..............yvgesekkirelfkeakeka..kpsilfiDEidal 70 
                 +yG  G+GKT++ k   + l+ +++l +s+s+ +  k               +++ +  i+++++ a +++  ++ il+iD++ + 
  EFC37273.1 112 FYGESGIGKTTMLKESLRLLEpFPYLLVSLSKTTtIKelaklmnlvvddeaRWSDIQLAINQFIALAHQNQkgQCPILIIDNANRN 197
                 8******************9777777777777773236999999999999988999999999999998888866799999998765 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.5
                 EEEEETTTCSSS.........STTHHHHH CS
         AAA  26 fleisgsellsk.........yvgesekk 45 
                 ++ ++++el+++         y+ e  +k
  EFC37273.1 320 IIMTKAAELIKDpngnhtlpqYITEETEK 348
                 34444444442234444444444444444 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   1.3e-05     0.027      10      83 ..      97     164 ..      91     203 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.3e-05
                 HHHHCTTTSCSEEEEEEESTTSSHHHHHHHHCCSHCCCCCCBTEEEEEEEESXXHHHHHHHXXHHHHHCCCTTS CS
      NB-ARC  10 ekLlekdelqslvvalvGmgGvGKttlakqilnksdevegrFdsvawvvvsktdkseeiletilkeLslseddl 83 
                 ++L  ++  ++ + +++G  G+GKtt++k+ l+      + F+    v++skt +++e+ + ++ ++ ++ + +
  EFC37273.1  97 NTLKSMQRCELSMRGFYGESGIGKTTMLKESLRL----LEPFPY-LLVSLSKTTTIKELAKLMNLVVDDE-ARW 164
                 56666666777799*************9987776....567875.5689999999999998766665443.444 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   1.7e-05     0.033      38      86 ..     112     158 ..      76     164 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.7e-05
       AAA_7  38 lvGptGtGKtviikdllkkldkekylsltinfsaqtsanqlqdiieskl 86 
                 ++G++G GKt+++k+ l+ l+   + +l +++s++t+ ++l ++++  +
  EFC37273.1 112 FYGESGIGKTTMLKESLRLLE--PFPYLLVSLSKTTTIKELAKLMNLVV 158
                 79****************999..8999999**********999987665 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       2.2   4.3e+03      71     119 ..      16      57 ..       4      82 .. 0.48
   2 ?   10.3   0.7   0.00024      0.49      26     129 ..     113     196 ..      96     223 .. 0.62

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.2
    ATPase_2  71 eeeekkklekalgiavpkaeleeilkeksklvfkaielllekikkkgkk 119
                 e +++k++++++   +  + +         l+ + ++ l  +i  + kk
  EFC37273.1  16 ERQKEKFIKQYKEVGIVVVGV-------VSLIVAVLNGLNSNIYSREKK 57 
                 444444444444222222222.......233444444444444444444 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00024
    ATPase_2  26 YGpegsGKtaLlkeiienledkdkyviyyialreesiskldefieeeeekkklekalgiavpkaeleeilkeksklvfkaielllekikkkgkk..iii 122
                 YG  g+GKt++lke++  le   +          +s+sk+++        k+l+k ++ +v  +e+      +  +++ ai+++++   +++k   +i+
  EFC37273.1 113 YGESGIGKTTMLKESLRLLEPFPYLL--------VSLSKTTTI-------KELAKLMNLVV-DDEA------RWSDIQLAINQFIALAHQNQKGqcPIL 189
                 9***************9997644432........333444443.......22333332222.2233......235556666665555555544455666 PP

    ATPase_2 123 iiDelqk 129
                 iiD + +
  EFC37273.1 190 IIDNANR 196
                 6665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (382 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       987  (0.0550505); expected 358.6 (0.02)
Passed bias filter:                      646  (0.036031); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.47
# Mc/sec: 2421.81
//
Query:       EFC37274.1  [L=501]
Description: hypothetical protein NAEGRDRAFT_59807 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.4e-48  159.7  19.8    2.4e-12   46.4   0.3    9.0 10  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.2   0.0    0.0084   1.5e+02      16      35 ..      69      88 ..      63     121 .. 0.73
   2 !   23.9   0.0   1.4e-09   2.5e-05       6      48 ..     176     218 ..     169     219 .. 0.83
   3 !   13.9   0.0   1.9e-06     0.033      19      43 ..     214     238 ..     211     244 .. 0.85
   4 !   17.8   0.0   1.1e-07     0.002       1      36 [.     246     281 ..     246     293 .. 0.84
   5 !   43.1   0.1   1.4e-15   2.5e-11       2      49 .]     294     341 ..     293     341 .. 0.98
   6 !   46.4   0.3   1.3e-16   2.4e-12       3      49 .]     320     366 ..     320     366 .. 0.99
   7 !   39.4   0.2   2.1e-14   3.7e-10       1      49 []     343     413 ..     343     413 .. 0.98
   8 !   22.0   0.0   5.4e-09   9.6e-05       1      49 []     390     439 ..     390     439 .. 0.93
   9 !   14.8   0.3   9.4e-07     0.017      12      40 ..     427     455 ..     418     461 .. 0.81
  10 ?   -0.1   0.0     0.045     8e+02      26      39 ..     466     479 ..     457     486 .. 0.68

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.0084
     DUF4116 16 lkylseeLknDkeivlkAvk 35
                l+yl+ e+ nD e + k   
  EFC37274.1 69 LYYLPIEYANDEETIQKVFS 88
                89*********998887665 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 1.4e-09
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 ++ + k+g +l+ ls++L nD+ +vlkAv++++  +  a++++
  EFC37274.1 176 MQFIGKDGGVLRRLSKSLINDRSFVLKAVEICPVDIFAAPDHF 218
                 456668888***********************97777777665 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 1.9e-06
     DUF4116  19 lseeLknDkeivlkAvkqngtalsy 43 
                 +++ ++nD+eiv+ A++++  +l+ 
  EFC37274.1 214 APDHFQNDREIVITALRNDAWILEN 238
                 6999**************9988765 PP

  == domain 4  score: 17.8 bits;  conditional E-value: 1.1e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 D++i   + +++  al ++se+L+nD  +++k  ++
  EFC37274.1 246 DEDIFELVARTDLAALMFASERLRNDTSFIMKMFRK 281
                 88898999999999*****************97765 PP

  == domain 5  score: 43.1 bits;  conditional E-value: 1.4e-15
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 rEi+++ vk ng++l++l+ee++ D+eiv  A+++++++l yase +r
  EFC37274.1 294 REIAMHMVKMNGLSLQFLNEEYRDDFEIVTCALNNHCHSLAYASERIR 341
                 9********************************************887 PP

  == domain 6  score: 46.4 bits;  conditional E-value: 1.3e-16
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Eiv+ a+ +++ +l y+se++++D+++++kA+++++ ++syas++Lr
  EFC37274.1 320 EIVTCALNNHCHSLAYASERIRSDRDFMKKAIEKYSVVYSYASDDLR 366
                 9*********************************************8 PP

  == domain 7  score: 39.4 bits;  conditional E-value: 2.1e-14
     DUF4116   1 DrEivleavkkngsalkylseeLkn......................DkeivlkAvkqngtalsyaseeLr 49 
                 Dr+++++a++k++ ++ y+s++L+n                      ++++v++Avk++   l ++++eL+
  EFC37274.1 343 DRDFMKKAIEKYSVVYSYASDDLRNndvelalisirggnwipvehemNRQVVKEAVKKSALQLTRVPDELK 413
                 9********************************************************************97 PP

  == domain 8  score: 22.0 bits;  conditional E-value: 5.4e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt.alsyaseeLr 49 
                 +r++v+eavkk  + l+ +++eLk+   ++ ++++     +l+y+ +eLr
  EFC37274.1 390 NRQVVKEAVKKSALQLTRVPDELKSCAPFMFEIINETTEpILKYITNELR 439
                 79*********9999999*****************8885389*******8 PP

  == domain 9  score: 14.8 bits;  conditional E-value: 9.4e-07
     DUF4116  12 ngsalkylseeLknDkeivlkAvkqngta 40 
                    +lky+ +eL+   ++vl+A+++++++
  EFC37274.1 427 TEPILKYITNELRFSQDFVLEAIRISSNN 455
                 4679********************98853 PP

  == domain 10  score: -0.1 bits;  conditional E-value: 0.045
     DUF4116  26 DkeivlkAvkqngt 39 
                 +ke+++k  +  g+
  EFC37274.1 466 NKEFAKKVAQLTGY 479
                 77887777666664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1007  (0.056166); expected 358.6 (0.02)
Passed bias filter:                      585  (0.0326287); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.21s 00:00:00.75 Elapsed: 00:00:00.40
# Mc/sec: 3768.32
//
Query:       EFC37275.1  [L=334]
Description: leucine-rich repeat protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.4e-52  171.3  23.1    1.1e-05   25.0   0.1    8.5  8  LRR_6      Leucine Rich repeat
    2.1e-26   91.4  43.1    1.7e-08   34.1   2.5    4.4  6  LRR_8      Leucine rich repeat
    4.2e-24   84.2  56.3    1.4e-05   25.3   2.2    6.2  9  LRR_4      Leucine Rich repeats (2 copies)
      2e-12   45.8  13.4        2.1    9.2   0.1    9.1  9  LRR_1      Leucine Rich Repeat
    2.2e-07   30.6   9.6    0.00051   19.6   0.8    3.8  3  LRR_9      Leucine-rich repeat
    0.00048   20.0   0.9         54    3.6   0.0    5.2  5  DUF4347    Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
       0.16   12.3  17.1         16    6.0   0.2    6.0  8  CLU_N      Mitochondrial function, CLU-N-term
       0.21   12.6   2.3        2.5    9.1   0.5    3.0  4  bZIP_C     Basic leucine-zipper C terminal


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.1   7.5e-08   0.00017       5      24 .]     137     156 ..     134     156 .. 0.92
   2 !   22.7   0.1   2.8e-08   6.4e-05       5      24 .]     161     180 ..     158     180 .. 0.92
   3 !   22.9   0.1   2.5e-08   5.5e-05       5      24 .]     185     204 ..     182     204 .. 0.93
   4 !   22.1   0.0   4.3e-08   9.7e-05       5      24 .]     209     228 ..     206     228 .. 0.92
   5 !   23.6   0.3   1.4e-08   3.2e-05       5      24 .]     233     252 ..     230     252 .. 0.92
   6 !   25.0   0.1   5.1e-09   1.1e-05       5      24 .]     257     276 ..     254     276 .. 0.93
   7 !   20.8   0.1   1.1e-07   0.00026       5      24 .]     281     300 ..     278     300 .. 0.93
   8 !   23.2   0.0     2e-08   4.6e-05       5      24 .]     305     324 ..     302     324 .. 0.93

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 7.5e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L +s+N+IgDeG++ ++
  EFC37275.1 137 LTSLIISDNGIGDEGVKLIS 156
                 9***************9985 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 2.8e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s N IgDeG++ ++
  EFC37275.1 161 LTSLNMSNNRIGDEGVKLIS 180
                 9***************9985 PP

  == domain 3  score: 22.9 bits;  conditional E-value: 2.5e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s NdIg eG+++++
  EFC37275.1 185 LTSLDISLNDIGAEGVKSIS 204
                 9****************996 PP

  == domain 4  score: 22.1 bits;  conditional E-value: 4.3e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++++N IgDeG++ ++
  EFC37275.1 209 LTSLNINYNRIGDEGVKLIS 228
                 9***************9985 PP

  == domain 5  score: 23.6 bits;  conditional E-value: 1.4e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s N+IgDeG++ ++
  EFC37275.1 233 LTSLNISNNGIGDEGVKLIS 252
                 9***************9985 PP

  == domain 6  score: 25.0 bits;  conditional E-value: 5.1e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s N+IgDeG+++++
  EFC37275.1 257 LTSLNISNNGIGDEGVKSIS 276
                 9****************996 PP

  == domain 7  score: 20.8 bits;  conditional E-value: 1.1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s N Ig eGa++++
  EFC37275.1 281 LTSLNISNNRIGAEGAKSIS 300
                 9****************996 PP

  == domain 8  score: 23.2 bits;  conditional E-value: 2e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++++N+IgDeG+++++
  EFC37275.1 305 LTSLSINYNQIGDEGVKSIS 324
                 9****************996 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.2   2.6e+03       9      21 ..      53      65 ..      51      71 .. 0.79
   2 !   26.6   2.5   1.6e-09   3.6e-06       2      61 .]     136     195 ..     135     195 .. 0.97
   3 !   26.2   4.0   2.2e-09   4.9e-06       2      61 .]     184     243 ..     183     243 .. 0.97
   4 !   27.8   4.3     7e-10   1.6e-06       2      61 .]     208     267 ..     207     267 .. 0.97
   5 !   34.1   2.5   7.4e-12   1.7e-08       2      61 .]     256     315 ..     255     315 .. 0.98
   6 !   28.1   0.4   5.7e-10   1.3e-06       2      55 ..     280     333 ..     279     333 .. 0.98

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.2
                TTS--SEE-TTSS CS
       LRR_8  9 snNrltslddeaF 21
                ++  ++ +dd++F
  EFC37275.1 53 CFEIISMIDDSWF 65
                5667999*****9 PP

  == domain 2  score: 26.6 bits;  conditional E-value: 1.6e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++s+N + + + +  + l++L++L++snN++     + +s L++L+sLd+s N++
  EFC37275.1 136 QLTSLIISDNGIGDEGVKLISELKQLTSLNMSNNRIGDEGVKLISELKQLTSLDISLNDI 195
                 7*******************************************************9987 PP

  == domain 3  score: 26.2 bits;  conditional E-value: 2.2e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+s N + + + ++ + +++L++L++++N++     + +s L++L+sL++s+N +
  EFC37275.1 184 QLTSLDISLNDIGAEGVKSISEMKQLTSLNINYNRIGDEGVKLISELKQLTSLNISNNGI 243
                 7*********************************************************86 PP

  == domain 4  score: 27.8 bits;  conditional E-value: 7e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL+++ Nr+ + + +  + l++L++L++snN +     + +s +++L+sL++s+N +
  EFC37275.1 208 QLTSLNINYNRIGDEGVKLISELKQLTSLNISNNGIGDEGVKLISEMKQLTSLNISNNGI 267
                 7*********************************************************86 PP

  == domain 5  score: 34.1 bits;  conditional E-value: 7.4e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++snN + + + ++ + l++L++L++snN++    ++++s +++L+sL +++N++
  EFC37275.1 256 QLTSLNISNNGIGDEGVKSISELKQLTSLNISNNRIGAEGAKSISEMKQLTSLSINYNQI 315
                 7*********************************************************98 PP

  == domain 6  score: 28.1 bits;  conditional E-value: 5.7e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 +LtsL++snNr+ + + ++ + +++L++L++++N++     +++s++++L+sL+
  EFC37275.1 280 QLTSLNISNNRIGAEGAKSISEMKQLTSLSINYNQIGDEGVKSISDMKQLTSLN 333
                 7***************************************************97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.2       2.3   5.1e+03      26      37 ..      22      31 ..      10      35 .. 0.59
   2 !   23.9   0.5   1.7e-08   3.8e-05       1      38 [.     135     173 ..     135     176 .. 0.87
   3 !   20.8   1.7   1.6e-07   0.00036       1      39 [.     159     195 ..     159     203 .. 0.86
   4 !   15.5   0.8     8e-06     0.018       1      38 [.     183     221 ..     183     228 .. 0.78
   5 !   23.3   1.8   2.8e-08   6.2e-05       1      38 [.     207     245 ..     207     249 .. 0.86
   6 !   25.3   2.2   6.4e-09   1.4e-05       1      38 [.     231     269 ..     231     279 .. 0.83
   7 !   24.8   2.2   9.5e-09   2.1e-05       1      36 [.     255     291 ..     255     301 .. 0.84
   8 !   23.3   0.6   2.7e-08   6.1e-05       1      38 [.     279     317 ..     279     322 .. 0.85
   9 !   12.3   0.2   7.7e-05      0.17       1      29 [.     303     333 ..     303     333 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.3
                -EEE-.-S---- CS
       LRR_4 26 keLdLsgNnlit 37
                 ++d   Nn  +
  EFC37275.1 22 LTIDF--NNHNK 31
                33333..33333 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 1.7e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L +s+N + d +  l + l++L++L++ +Nn+i+d
  EFC37275.1 135 KQLTSLIISDNGIGDEGVkLISeLKQLTSLNM-SNNRIGD 173
                 58*************99996655*********.6669876 PP

  == domain 3  score: 20.8 bits;  conditional E-value: 1.6e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdl 39 
                 ++L++L+ snN++ d +  l + l++L++Ld+s N    d+
  EFC37275.1 159 KQLTSLNMSNNRIGDEGVkLISeLKQLTSLDISLN----DI 195
                 58*************99996655*********657....66 PP

  == domain 4  score: 15.5 bits;  conditional E-value: 8e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+s N +   +   ++ +++L++L+++ N +i+d
  EFC37275.1 183 KQLTSLDISLNDIGAEGVksISEMKQLTSLNINYN-RIGD 221
                 589******77977555554334*********777.8765 PP

  == domain 5  score: 23.3 bits;  conditional E-value: 2.8e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L+++ N++ d +  l + l++L++L++ +Nn i+d
  EFC37275.1 207 KQLTSLNINYNRIGDEGVkLISeLKQLTSLNI-SNNGIGD 245
                 58*************99996655*********.5558765 PP

  == domain 6  score: 25.3 bits;  conditional E-value: 6.4e-09
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L++snN + d +  l + +++L++L++ +Nn i+d
  EFC37275.1 231 KQLTSLNISNNGIGDEGVkLISeMKQLTSLNI-SNNGIGD 269
                 58*************99996655*********.5558855 PP

  == domain 7  score: 24.8 bits;  conditional E-value: 9.5e-09
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L++snN + d +   ++ l++L++L++ +Nn+i
  EFC37275.1 255 KQLTSLNISNNGIGDEGVksISELKQLTSLNI-SNNRI 291
                 58************999986445*********.55577 PP

  == domain 8  score: 23.3 bits;  conditional E-value: 2.7e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++snN++   +   ++ +++L++L+++ N +i+d
  EFC37275.1 279 KQLTSLNISNNRIGAEGAksISEMKQLTSLSINYN-QIGD 317
                 58************877776445*********777.9876 PP

  == domain 9  score: 12.3 bits;  conditional E-value: 7.7e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLd 29 
                 ++L++L+++ Nq+ d +   ++ +++L++L+
  EFC37275.1 303 KQLTSLSINYNQIGDEGVksISDMKQLTSLN 333
                 58************998885556******97 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1       1.5   3.3e+03       7      15 ..      67      75 ..      60      80 .. 0.79
   2 ?    1.4   0.0      0.34   7.7e+02       2      18 ..     137     153 ..     136     158 .. 0.76
   3 !    7.0   0.1    0.0049        11       1      18 [.     160     177 ..     160     182 .. 0.77
   4 ?    2.4   0.0      0.16   3.5e+02       1      19 [.     184     202 ..     184     206 .. 0.74
   5 ?    5.9   0.1     0.011        25       1      18 [.     208     225 ..     208     230 .. 0.77
   6 !    6.9   0.0    0.0053        12       1      16 [.     232     247 ..     232     254 .. 0.78
   7 !    9.2   0.1   0.00094       2.1       1      23 []     256     278 ..     256     278 .. 0.88
   8 !    7.9   0.0    0.0026       5.8       1      20 [.     280     299 ..     280     302 .. 0.79
   9 ?    4.5   0.0     0.032        73       1      21 [.     304     324 ..     304     326 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.5
       LRR_1  7 Lsnnpllgl 15
                L+n++l+++
  EFC37275.1 67 LNNCSLISK 75
                899999755 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.34
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L++L +s+n +++ +  
  EFC37275.1 137 LTSLIISDNGIGDEGVK 153
                 99*******99776655 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0049
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L++snn++++ +  
  EFC37275.1 160 QLTSLNMSNNRIGDEGVK 177
                 599********9776655 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++Ld+s n ++  +  s
  EFC37275.1 184 QLTSLDISLNDIGAEGVKS 202
                 599*****99986555555 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L++++n++++ +  
  EFC37275.1 208 QLTSLNINYNRIGDEGVK 225
                 599********9776655 PP

  == domain 6  score: 6.9 bits;  conditional E-value: 0.0053
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L++snn +++ +
  EFC37275.1 232 QLTSLNISNNGIGDEG 247
                 599*******997655 PP

  == domain 7  score: 9.2 bits;  conditional E-value: 0.00094
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++L++snn +++ +  s++ L
  EFC37275.1 256 QLTSLNISNNGIGDEGVKSISEL 278
                 599*********99999998765 PP

  == domain 8  score: 7.9 bits;  conditional E-value: 0.0026
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++snn+++  ++ s+
  EFC37275.1 280 QLTSLNISNNRIGAEGAKSI 299
                 599********977666666 PP

  == domain 9  score: 4.5 bits;  conditional E-value: 0.032
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L +++n++++ +  s++
  EFC37275.1 304 QLTSLSINYNQIGDEGVKSIS 324
                 599*********998888775 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.5   0.00017      0.38      57     123 ..     128     193 ..      70     198 .. 0.79
   2 !   19.6   0.8   2.3e-07   0.00051      40     125 ..     181     267 ..     176     273 .. 0.89
   3 !   12.8   0.3   2.8e-05     0.062      42     118 ..     255     332 ..     250     334 .] 0.76

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00017
       LRR_9  57 ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                    +  +k+l +l++++n i   + +l   l +l++l ++nn++ + + ++ + +lk+l++l +  n
  EFC37275.1 128 AKFISEMKQLTSLIISDNGIGDEGVKLISELKQLTSLNMSNNRIGDEG-VKLISELKQLTSLDISLN 193
                 555566788888888888888888888888888888888888888755.467777777777766555 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 2.3e-07
       LRR_9  40 tldqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                  l q+ ++d+s ndi    + ++  +k+l +l +n nri   + +l   l +l++l ++nn + + + ++ + ++k+l++l + +n +
  EFC37275.1 181 ELKQLTSLDISLNDIgaEGVKSISEMKQLTSLNINYNRIGDEGVKLISELKQLTSLNISNNGIGDEG-VKLISEMKQLTSLNISNNGI 267
                 57899999999999944569999****************************************9976.58999********9999876 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 2.8e-05
       LRR_9  42 dqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklell 118
                  q+ ++++s+n i +  + ++  lk+l +l ++nnri   + +    + +l++l ++ n++ + + ++ + ++k+l++l
  EFC37275.1 255 KQLTSLNISNNGIGDegVKSISELKQLTSLNISNNRIGAEGAKSISEMKQLTSLSINYNQIGDEG-VKSISDMKQLTSL 332
                 67888899999985433888899999999999999998888887788899999999999987754.3666666666654 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.027        61     101     127 ..     146     170 ..     132     174 .. 0.82
   2 ?    3.6   0.0     0.024        54     103     122 ..     172     191 ..     167     201 .. 0.88
   3 ?    3.0   0.0     0.035        79     103     122 ..     220     239 ..     218     246 .. 0.87
   4 ?    2.2   0.0     0.064   1.4e+02     101     122 ..     242     263 ..     239     268 .. 0.87
   5 ?    2.1   0.0     0.068   1.5e+02     102     130 ..     267     293 ..     263     304 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.027
     DUF4347 101 AageaGeafvekLaqltgadvaAstdl 127
                 + g++G +++++L+qlt  ++  s+++
  EFC37275.1 146 GIGDEGVKLISELKQLTSLNM--SNNR 170
                 66899************9886..4445 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.024
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +++++L+qlt  d++
  EFC37275.1 172 GDEGVKLISELKQLTSLDIS 191
                 789**************995 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.035
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +++++L+qlt  +++
  EFC37275.1 220 GDEGVKLISELKQLTSLNIS 239
                 689*************9995 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.064
     DUF4347 101 AageaGeafvekLaqltgadva 122
                 + g++G +++++++qlt  +++
  EFC37275.1 242 GIGDEGVKLISEMKQLTSLNIS 263
                 56899*************9995 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.068
     DUF4347 102 ageaGeafvekLaqltgadvaAstdltGn 130
                  g++G + +++L+qlt  ++  s++++G+
  EFC37275.1 267 IGDEGVKSISELKQLTSLNI--SNNRIGA 293
                 6899*************999..5667775 PP

>> CLU_N  Mitochondrial function, CLU-N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.4       2.3   5.3e+03      23      54 ..      11      41 ..       6      46 .. 0.52
   2 ?   -0.4   0.0      0.69   1.5e+03      23      66 ..      53      98 ..      52     101 .. 0.71
   3 ?    2.6   0.1     0.079   1.8e+02      13      43 ..     153     186 ..     149     195 .. 0.61
   4 ?    4.4   0.1     0.022        50      15      45 ..     179     212 ..     174     231 .. 0.59
   5 ?    6.0   0.2    0.0071        16      14      45 ..     202     236 ..     197     250 .. 0.72
   6 ?    4.5   0.1      0.02        44      13      45 ..     225     260 ..     222     269 .. 0.74
   7 ?    5.7   0.1    0.0085        19      13      47 ..     249     283 ..     245     291 .. 0.70
   8 ?    5.4   0.0      0.01        23      15      45 ..     299     332 ..     296     334 .] 0.81

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.3
       CLU_N 23 nyhLkyengngerl.nefvtlseiieeedvdel 54
                ny+L ++  +++ l  +f++ ++ +ee+ ++ +
  EFC37275.1 11 NYQLINS--EEQLLtIDFNNHNKSLEEKAKKVV 41
                7888553..223333355555555555555555 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.69
       CLU_N 23 nyhLkye.ngngerlnefvtlseiieeedvdelkLelkek.pYter 66
                ++++    ++ + +ln+ + +s+ + + +++  kL +++k ++te+
  EFC37275.1 53 CFEIISMiDDSWFILNNCSLISKQFFNVIKERSKLVIQFKkKFTEK 98
                6666444444788888888888888888888889998875257766 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.079
       CLU_N  13 selpstkylTnyhLkye..ng.ngerlnefvtls 43 
                 ++++++k+lT+ ++ ++  ++   + ++e+++l 
  EFC37275.1 153 KLISELKQLTSLNMSNNriGDeGVKLISELKQLT 186
                 5678899999999977644222333334444443 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.022
       CLU_N  15 lpstkylTnyhLkye..ng.ngerlnefvtlsei 45 
                 ++++k+lT+ ++  +  +    ++++e+++l  +
  EFC37275.1 179 ISELKQLTSLDISLNdiGAeGVKSISEMKQLTSL 212
                 6666777777776664423345555555555544 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.0071
       CLU_N  14 elpstkylTnyhLkye..ng.ngerlnefvtlsei 45 
                  ++++k+lT+ +++y+  ++   + ++e+++l  +
  EFC37275.1 202 SISEMKQLTSLNINYNriGDeGVKLISELKQLTSL 236
                 67899********9987644355666777777665 PP

  == domain 6  score: 4.5 bits;  conditional E-value: 0.02
       CLU_N  13 selpstkylTnyhLkye..ng.ngerlnefvtlsei 45 
                 ++++++k+lT+ ++ ++  ++   + ++e+++l  +
  EFC37275.1 225 KLISELKQLTSLNISNNgiGDeGVKLISEMKQLTSL 260
                 578899999*99998887644456667888888766 PP

  == domain 7  score: 5.7 bits;  conditional E-value: 0.0085
       CLU_N  13 selpstkylTnyhLkyeng.ngerlnefvtlseiie 47 
                 ++++++k+lT+ ++ ++ g  +e ++  ++l+++ +
  EFC37275.1 249 KLISEMKQLTSLNISNN-GiGDEGVKSISELKQLTS 283
                 678999********886.445666666666666543 PP

  == domain 8  score: 5.4 bits;  conditional E-value: 0.01
       CLU_N  15 lpstkylTnyhLkye..ng.ngerlnefvtlsei 45 
                 ++++k+lT+ +++y+  ++   ++++++++l  +
  EFC37275.1 299 ISEMKQLTSLSINYNqiGDeGVKSISDMKQLTSL 332
                 6789**********98755578899999998766 PP

>> bZIP_C  Basic leucine-zipper C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.25   5.7e+02      72     119 ..     144     172 ..     105     198 .. 0.61
   2 ?    2.4   0.0      0.14     3e+02      67     118 ..     163     219 ..     147     225 .. 0.67
   3 ?    9.1   0.5    0.0011       2.5      60     119 ..     228     292 ..     170     317 .. 0.68
   4 ?   -2.1   0.0       3.3   7.3e+03      89     111 ..     310     332 ..     294     334 .] 0.45

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.25
      bZIP_C  72 nnglpdissvelqekadlanaavaagkmgrtasLqrvasLehlqkrir 119
                 +ng++d ++                     +++L++ +sL+   +ri 
  EFC37275.1 144 DNGIGDEGVK-------------------LISELKQLTSLNMSNNRIG 172
                 3333333333...................4444455555554444443 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.14
      bZIP_C  67 dlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkri 118
                 +l+++nn ++d ++  + e ++l +  ++ +++g      ++++++ +sL+   +ri
  EFC37275.1 163 SLNMSNNRIGDEGVKLISELKQLTSLDISLNDIGaegvkSISEMKQLTSLNINYNRI 219
                 456677777777766555555556666666666666555777788888887777777 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.0011
      bZIP_C  60 nltstaddlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkrir 119
                 +  +  ++l+++nng++d ++  + e ++l + +++++++g      +++L++ +sL+   +ri 
  EFC37275.1 228 SELKQLTSLNISNNGIGDEGVKLISEMKQLTSLNISNNGIGdegvkSISELKQLTSLNISNNRIG 292
                 55555667788888898888887777777777777888888777778888899999988888885 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 3.3
      bZIP_C  89 lanaavaagkmgrtasLqrvasL 111
                 ++ +++ ++++  ++ +++ +sL
  EFC37275.1 310 INYNQIGDEGVKSISDMKQLTSL 332
                 22233333333355555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       942  (0.0525406); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 1995.75
//
Query:       EFC37276.1  [L=1017]
Description: transmembrane protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.2e-24   86.2  17.4    2.2e-24   86.2  17.4    3.2  4  RSN1_7TM        Calcium-dependent channel, 7TM region, putati
    6.2e-07   29.3   1.2    8.3e-06   25.7   0.9    4.9  6  RSN1_TM         Late exocytosis, associated with Golgi transp
    0.00086   19.0   1.5      0.095   12.4   0.2    3.1  3  FAM176          FAM176 family
  ------ inclusion threshold ------
       0.15   12.5   0.1        0.4   11.1   0.1    1.7  1  FAM163          FAM163 family
       0.47   10.8   8.7        1.2    9.4   4.0    3.8  3  FA_hydroxylase  Fatty acid hydroxylase superfamily
        5.8    7.8  10.3        1.4    9.7   5.6    2.3  2  DMAP_binding    DMAP1-binding Domain
        9.8    5.8   8.3        4.6    6.9   0.9    3.4  4  DUF4131         Domain of unknown function (DUF4131)


Domain annotation for each model (and alignments):
>> RSN1_7TM  Calcium-dependent channel, 7TM region, putative phosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.3      0.75   1.9e+03      51      72 ..      35      56 ..      23      65 .. 0.72
   2 ?   -2.6   1.8         1   2.7e+03     184     219 ..     198     233 ..     160     238 .. 0.54
   3 !   86.2  17.4   8.8e-28   2.2e-24       3     242 ..     654     898 ..     652     903 .. 0.95
   4 ?   -2.5   1.0      0.99   2.5e+03      55      75 ..     955     975 ..     915     983 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.75
    RSN1_7TM 51 svvtgllPtlllslllallpii 72
                +v+t+l++++l +ll++ll ++
  EFC37276.1 35 GVLTTLVANILIALLYMLLFFL 56
                5677777777777777777655 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1
    RSN1_7TM 184 erytkppsfdygteypkvllifvialiYsviaPlil 219
                 +++ +++  d  +++    +i+ i+l+ s++a ++l
  EFC37276.1 198 KKMMALYGKDIVIYLYFQQIILYIMLVCSILACVVL 233
                 223244444444444444455667777777777666 PP

  == domain 3  score: 86.2 bits;  conditional E-value: 8.8e-28
    RSN1_7TM   3 livtlllvlliifwiipvafvgllsnletltkvlpflkkilelskkll.svvtgllPtlllslllallpiilrllsklqGalsrselelsvvskyfaFl 100
                 ++++l+lvl++i+ + p ++++++ +l ++  v   ++ki ++ + ++ s+  ++lP+  l +++ l+ +++  +++l  + s++e ++  + + ++++
  EFC37276.1 654 IMIHLFLVLFFIVASSPASILSAIQSLFNVGVVDMDIQKI-QRATGIVgSIFFQFLPSFFLYWISRLIGFVISKVTMLGKYDSNQEYKRIYLLRKYFYM 751
                 78999***********************************.77777776999****************************************9****** PP

    RSN1_7TM 101 vvnvFlvftlagtalslleeiidnptsipkllae.slpkasnFfityillqglagaaleLlqlvklilflikrkfls....ktprdlaerytkppsfdy 194
                 v+ ++++++l  ++++ + + i++++++ ++la+ +lp +++ +++  ++ +l+g   +L++  + +++++k+k+      k p ++  + t+   f+ 
  EFC37276.1 752 VLTILVMPSLWLSSMDGIVNYIKTEENFQEMLANiFLPASGALMVSTAIQYALIGNLDDLIRTEDAFWYIWKTKLSPyrkaKSPLEKLRAATDQFYFSV 850
                 ********************************98577*************************************9988888899999999999999999 PP

    RSN1_7TM 195 gteypkvllifvialiYsviaPlilpfaliyfllgylvykyqllyvyd 242
                  t+y+k+l +f+++++Ysv+ P+ilp++l+y+++++++++y l  +y 
  EFC37276.1 851 DTNYAKILAVFTLCMCYSVFIPIILPCGLFYMMMKHWIDRYLLQEIYT 898
                 9*****************************************988886 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 0.99
    RSN1_7TM  55 gllPtlllslllallpiilrl 75 
                  +lP l+ s++ ++l + l +
  EFC37276.1 955 AFLPHLIISIVVFVLLVCLLY 975
                 455555555555555555444 PP

>> RSN1_TM  Late exocytosis, associated with Golgi transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.0   0.00011      0.27       2      40 ..      36      81 ..      35     100 .. 0.77
   2 !   25.7   0.9   3.2e-09   8.3e-06      60     154 ..     193     325 ..     179     327 .. 0.67
   3 ?   -4.4   1.4       5.8   1.5e+04       7      22 ..     651     666 ..     649     668 .. 0.65
   4 ?   -5.4   2.0         7   1.8e+04      90     101 ..     862     871 ..     854     885 .. 0.49
   5 ?   -0.5   1.3      0.36   9.1e+02       4      33 ..     929     958 ..     926     966 .. 0.83
   6 ?   -1.6   2.8      0.78     2e+03      90     140 ..     960    1005 ..     939    1012 .. 0.50

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00011
     RSN1_TM  2 lltslvinlvlalvflllFlilRkknkrvYaprtylkg........e 40
                +lt+lv n+++al+++llF ++ +++ ++++pr+++k         e
  EFC37276.1 36 VLTTLVANILIALLYMLLFFLCCRQL-SLFNPRKKKKLfdeymrdlE 81
                79*****************9987755.799***99876665544331 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 3.2e-09
     RSN1_TM  60 lkisdeeilekaGLDayvflrflkmlikiflvlavlalivLlPvn..............atggegedskesk........................... 117
                  k + +++++  G D +++l f ++++ i+lv+++la++vLlP++                          +                           
  EFC37276.1 193 AKQERKKMMALYGKDIVIYLYFQQIILYIMLVCSILACVVLLPIHlsgnppifeysmnnS-----------Sssfnylpssddislysnsdvlqkgikp 280
                 55666788999999*******************************666666554222220...........0223346777445555554444444444 PP

     RSN1_TM 118 ........sgldklsisnvsegsn..............rlwahvvvayiftglvlylly 154
                         +                             +l+ahvvv +i + + l++++
  EFC37276.1 281 iknltqedN--------------IllrttvemvidspvALYAHVVVGIISICVGLFFFF 325
                 444444433..............055555555555555**********99999888876 PP

  == domain 3  score: -4.4 bits;  conditional E-value: 5.8
     RSN1_TM   7 vinlvlalvflllFli 22 
                 ++n+++ l+++l+F++
  EFC37276.1 651 ATNIMIHLFLVLFFIV 666
                 5667777777777765 PP

  == domain 4  score: -5.4 bits;  conditional E-value: 7
     RSN1_TM  90 lvlavlalivLl 101
                 +++++++  v +
  EFC37276.1 862 TLCMCYS--VFI 871
                 2222222..222 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 0.36
     RSN1_TM   4 tslvinlvlalvflllFlilRkknkrvYap 33 
                   ++i+l++++ fl++F  lR      + p
  EFC37276.1 929 KVFIIALSMSAWFLIVFFGLRVYTTAAFLP 958
                 568999***************988777766 PP

  == domain 6  score: -1.6 bits;  conditional E-value: 0.78
     RSN1_TM   90 lvlavlalivLlPvnatggegedskesksgldklsisnvsegsnrlwahvv 140 
                  l++++++++ L+ + +  +++e +    + ++k  +s+v+++++ ++ h+ 
  EFC37276.1  960 LIISIVVFVLLVCLLYLIHHNE-D----KIIRKRVMSQVEKQNHEVFHHFA 1005
                  2333333333333333333222.2....24678888888666555555554 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.2   3.7e-05     0.095      35     108 ..      45     118 ..      35     126 .. 0.58
   2 ?    3.4   0.0     0.021        53      27      68 ..     314     355 ..     304     395 .. 0.74
   3 ?   -0.9   0.0      0.45   1.2e+03     110     130 ..     505     528 ..     488     543 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.7e-05
      FAM176  35 lltLcllviriscrkdle.rlkkkkkklkeesekasededeeeeeeeedsseseaeeelsefertlsvnvftsae 108
                 l++L+ +++   c ++l+  + +kkkkl +e  ++ e+e   ++ +ee++s+++++++ +++e + + + +tsa 
  EFC37276.1  45 LIALLYMLLFFLCCRQLSlFNPRKKKKLFDEYMRDLEEEKAHQQANEEEDSSHHSQQQQQHVENS-NNEYYTSAS 118
                 55555555555555555546666777777777677444444444444444444445555666666.777888875 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.021
      FAM176  27 vlgvcvGLlltLcllviriscrkdlerlkkkkkklkeeseka 68 
                 ++++cvGL++ +  +  ++  +++ +++  ++++ +  s+++
  EFC37276.1 314 IISICVGLFFFFHFVFHEVVVENQSREEIVHQEDSNIISSQK 355
                 789*********999999999999886666665555444433 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.45
      FAM176 110 lerAqRlEeReriir.EI..Wrng 130
                  e  q lE R r+ir E+  W  +
  EFC37276.1 505 EEAIQHLETRKRLIRkEVskWDAS 528
                 466799******998343335555 PP

>> FAM163  FAM163 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   0.00016       0.4       9      88 ..      33     107 ..      29     138 .. 0.55

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00016
      FAM163   9 tGGilatviLLciiavLCyCRLqYYCCkkdeseeeeeeepefav.leplacnacssevvdgsaatangpaelssslakkak 88 
                 +GG+l t +  ++ia+L y  L + CC++    +  ++++ f++ +++l     ++e ++++a++ + ++++s++++++++
  EFC37276.1  33 AGGVLTTLVANILIALL-YMLLFFLCCRQLSLFNPRKKKKLFDEyMRDL-----EEEKAHQQANEEEDSSHHSQQQQQHVE 107
                 79*******99999977.889******9988777666666665543333.....111111112221111111111111111 PP

>> FA_hydroxylase  Fatty acid hydroxylase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.66   1.7e+03     102     117 ..      88     103 ..      25     120 .. 0.56
   2 ?   -0.1   0.0      0.44   1.1e+03      11      22 ..     321     332 ..     302     367 .. 0.71
   3 ?    9.4   4.0   0.00048       1.2      45     119 ..     936    1009 ..     928    1015 .. 0.62

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.66
  FA_hydroxylase 102 latpraHrlHHsknee 117
                      a  +  + HHs++++
      EFC37276.1  88 QANEEEDSSHHSQQQQ 103
                     4444555556665554 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.44
  FA_hydroxylase  11 veYwvHrllHrv 22 
                     +++++H ++H+v
      EFC37276.1 321 LFFFFHFVFHEV 332
                     477888888873 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00048
  FA_hydroxylase   45 lrahplealllallllllllllgplsalll.vlvlaallelliHsg.lhvslgwllerllatpraHrlHHskneegn 119 
                      +  +++ +++++l ++  +++l++l   ++ +++l  ll+l++H + + ++ + + ++ +  +++  +HH+  + + 
      EFC37276.1  936 SMSAWFLIVFFGLRVYTTAAFLPHLIISIVvFVLLVCLLYLIHHNEdKIIRKRVM-SQ-VEKQNHEVFHHFATN-TA 1009
                      4445566666669999999999999999994555556666665555433344333.44.455566667888766.44 PP

>> DMAP_binding  DMAP1-binding Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   5.6   0.00056       1.4      32      90 ..      67     127 ..      66     136 .. 0.62
   2 ?   -1.0   0.1       1.2   3.1e+03      27      86 ..     476     537 ..     467     570 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00056
  DMAP_binding  32 kkklkLLreFlpnslkae..nqa.apesklsaeakqqlasletklrde.elssevytekvqaa 90 
                   +kk+kL +e++   l++e  +q+ + e+  s++++qq+ ++ +++++e   s ++ t+++++a
    EFC37276.1  67 RKKKKLFDEYM-RDLEEEkaHQQaNEEEDSSHHSQQQQ-QHVENSNNEyYTSASTITNQITSA 127
                   79*********.55555546455255666666666666.555556666355555555556655 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.2
  DMAP_binding  27 eKgyekkklkLLreFlpnslkae.nqaap.esklsaeakqqlasletklrdeelssevytek 86 
                   ++g + +k+ L + F      ++ n  ++ e  ++ e++++l ++e +  d ++ +  +t++
    EFC37276.1 476 DEGVVDSKNVLSHCFGVHTHGKKiNMLNTeEAIQHLETRKRLIRKEVSKWDASYNQLLHTKN 537
                   56777777777777774444444555555577777777777766666666666666666655 PP

>> DUF4131  Domain of unknown function (DUF4131)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.077     2e+02       8      27 ..      44      67 ..      28      87 .. 0.63
   2 ?   -3.7   0.1       3.1   7.9e+03      40     130 ..     228     231 ..     210     248 .. 0.49
   3 ?   -2.1   0.0         1   2.6e+03      33      59 ..     316     342 ..     306     354 .. 0.59
   4 ?    6.9   0.9    0.0018       4.6       5      51 ..     928     979 ..     925    1000 .. 0.73

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.077
     DUF4131  8 vllalllllllllllllrr....r 27
                +l+all +ll++l++++++    r
  EFC37276.1 44 ILIALLYMLLFFLCCRQLSlfnpR 67
                345555555555555554444222 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 3.1
     DUF4131  40 lllallgfalrapqpnandlsqllesgqeviveGvvaslpeltgsgtrfvlevervlsagktkpvsgrvlvtvpkspaeglrpGdrlrltg 130
                 l+                                                                                        +
  EFC37276.1 228 LA---------------------------------------------------------------------------------------CV 231
                 11.......................................................................................11 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1
     DUF4131  33 llllllllllallgfalrapqpnandl 59 
                  ++++l++++ +++  + + +++++++
  EFC37276.1 316 SICVGLFFFFHFVFHEVVVENQSREEI 342
                 344555555555555555555555555 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0018
     DUF4131   5 lalvllalllllllllllllrr.....rprrrvllllllllllallgfalra 51 
                 ++++++al + + +l++++ +r     +  ++ ++++ ++ ll++l ++++ 
  EFC37276.1 928 VKVFIIALSMSAWFLIVFFGLRvyttaAFLPHLIISIVVFVLLVCLLYLIHH 979
                 678999999999******9999877775556666666666666666555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1017 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2706  (0.150929); expected 358.6 (0.02)
Passed bias filter:                      949  (0.052931); expected 358.6 (0.02)
Passed Vit filter:                       109  (0.00607954); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.93u 0.31s 00:00:01.24 Elapsed: 00:00:00.50
# Mc/sec: 6103.26
//
Query:       EFC37277.1  [L=1616]
Description: hypothetical protein NAEGRDRAFT_59809 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.11   13.1   0.0        0.4   11.3   0.0    2.0  1  OAD_gamma  Oxaloacetate decarboxylase, gamma chain


Domain annotation for each model (and alignments):
>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   2.3e-05       0.4       2      55 ..    1377    1441 ..    1376    1456 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.3e-05
   OAD_gamma    2 egllltllGmgvVFvvLilLslvislfskiikkk...........akkkkkkakaaaaaaaaaaa 55  
                  ++l ++ l +g++F++L++L l + l  ++ikk            a k++++  + +  ++a++a
  EFC37277.1 1377 QALGISGLVLGTIFLFLTVLFLGTALADYLIKKSvndqwifksifATKSARQHHNITTHSNASTA 1441
                  6888999999****************999988886666666655544444444444444444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1616 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1475  (0.0822689); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.03u 0.33s 00:00:01.36 Elapsed: 00:00:00.55
# Mc/sec: 8807.75
//
Query:       EFC37278.1  [L=2590]
Description: hypothetical protein NAEGRDRAFT_59810 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.9e-10   40.3   0.1    1.4e-09   38.1   0.1    2.3  1  BTB            BTB/POZ domain
    8.5e-06   25.6   0.9    4.1e-05   23.4   0.1    2.6  2  F-box-like     F-box-like
    0.00025   20.9  11.6    0.00025   20.9  11.6    2.4  2  KASH_CCD       Coiled-coil region of CCDC155 or KASH
  ------ inclusion threshold ------
       0.11   12.4   0.1       0.62   10.0   0.0    2.4  2  F-box          F-box domain
        1.7    8.8   5.6        1.9    8.7   2.8    2.6  2  bZIP_1         bZIP transcription factor
        5.5    7.3  10.7        4.4    7.7   8.0    2.3  2  DUF641         Plant protein of unknown function (DUF641)


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.1   0.1   4.8e-13   1.4e-09       3     106 ..    1482    1575 ..    1480    1579 .. 0.87

  Alignments for each domain:
  == domain 1  score: 38.1 bits;  conditional E-value: 4.8e-13
                  HHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHH CS
         BTB    3 elresgelcDvtlvvgdgkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprl 99  
                  +l++ ++ +D+ ++vg ++++++hk vL +rS yF++lf+++         iel++  pe ++ l++++Y     ++ +     l++ a+  ++++l
  EFC37278.1 1482 DLFNDHSTSDICFLVG-NQKIHCHKTVLISRSVYFETLFEGN------W-SIELEEYGPE-MKYLIQYCYGFMNYVP-SIHQIPLIKKAHQHEMKDL 1568
                  789999**********.6************************......2.4889999997.899******9988887.8888899999999999999 PP

                  HHHHHHH CS
         BTB  100 kkaceef 106 
                  + ++++ 
  EFC37278.1 1569 IPIVSKQ 1575
                  8777665 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.83   2.5e+03       3      15 ..     534     546 ..     532     561 .. 0.78
   2 !   23.4   0.1   1.4e-08   4.1e-05       4      43 ..     940     980 ..     938     982 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.83
  F-box-like   3 rLPdEiLlqIFsy 15 
                 ++P ++++++Fs 
  EFC37278.1 534 SIPLDLICTVFSA 546
                 89*********94 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 1.4e-08
  F-box-like   4 LPdEiLlqIFsyL.ppsdLlrlalVCrrWrrvaldtplLWr 43 
                 LP +   +I+ yL p +  ++  +VC++W+++ + + +LW+
  EFC37278.1 940 LPSDMFFEILTYLtPEENAASFDRVCKHWHELSRQDSFLWQ 980
                 9************555578889******************6 PP

>> KASH_CCD  Coiled-coil region of CCDC155 or KASH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9  11.6   8.4e-08   0.00025      64     137 ..      32     105 ..      20     119 .. 0.88
   2 ?   -6.4   6.0         6   1.8e+04      94     145 ..     159     210 ..     137     244 .. 0.53

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 8.4e-08
    KASH_CCD  64 lleeEleelkalvkeleEkrarlkaqnkqlekenqsLiakiesLqeenikllaekdelkkklkeLlkekaeLkk 137
                  + +E+e lk++ ++ +E+ +++++q ++l+ e qsL++ ++++qe n+ l++e+d l  ++k L  e ++Lk 
  EFC37278.1  32 QMLDEIEGLKKIGQKKQEEIHQINQQHSKLQFEYQSLNTAMKTIQEMNQDLQSERDRLSAQVKALNGELSKLKA 105
                 34579**********************************************************99888888764 PP

  == domain 2  score: -6.4 bits;  conditional E-value: 6
    KASH_CCD  94 ekenqsLiakiesLqeenikllaekdelkkklkeLlkekaeLkkqlheleel 145
                    +q  +++ ++L+ + +  +a +   +++ ++ l+++  L +q ++++++
  EFC37278.1 159 IMQQQTQSQQAQALEGKEFFKQAKEVLTNRQFADFLQQIKLLNNQQQSAQQT 210
                 3344444444444444433333333344444444444444444444444433 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   0.00021      0.62       6      44 ..     940     979 ..     938     983 .. 0.92
   2 ?   -3.4   0.0       3.4     1e+04      13      30 ..    2214    2240 ..    2206    2240 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00021
                 S-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHHHH CS
       F-box   6 LPsevlrhILerLplsd.llalrrVSkgwrilidsdrlwc 44 
                 LPs+   +IL +L + +   ++ rV+k+w+ l + d++ +
  EFC37278.1 940 LPSDMFFEILTYLTPEEnAASFDRVCKHWHELSRQDSFLW 979
                 9********************************9998865 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 3.4
                  HHHHTS-HHH.........HHHHCTT- CS
       F-box   13 hILerLplsd.........llalrrVS 30  
                   ++e+L+++          +l++++ +
  EFC37278.1 2214 YVFEYLSTTGylspyaverILNCMQLC 2240
                  677887777655555566666666665 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   2.8   0.00063       1.9      22      62 ..      45      85 ..      38      87 .. 0.94
   2 ?    0.9   0.5      0.17     5e+02      30      53 ..      81     104 ..      76     117 .. 0.63

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00063
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1 22 qRKqaeieeLerrvkaLekeNksLkseleelkkevekLksk 62
                q+Kq+ei +  ++ ++L+ e +sL   +++++++++ L+s+
  EFC37278.1 45 QKKQEEIHQINQQHSKLQFEYQSLNTAMKTIQEMNQDLQSE 85
                9************************************9987 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.17
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  30 eLerrvkaLekeNksLkseleelk 53 
                  L+++ + L+++ k+L  el++lk
  EFC37278.1  81 DLQSERDRLSAQVKALNGELSKLK 104
                 455566666666666666665555 PP

>> DUF641  Plant protein of unknown function (DUF641)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   8.0    0.0015       4.4      50     124 ..      34     109 ..      27     112 .. 0.84
   2 ?   -3.2   0.0       3.3     1e+04      53     108 ..    2094    2147 ..    2092    2149 .. 0.60

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0015
      DUF641  50 Lkklselkrlyrkkqkkkas.eaeeseleaeiqeqrsllktyeitvkkleaelkakdseieeLkekLeeaeksnkk 124
                 L ++  lk+   kkq++ ++ ++++s+l+ e q +  ++kt + + ++l++e ++  ++++ L+ +L+++++ +k+
  EFC37278.1  34 LDEIEGLKKIGQKKQEEIHQiNQQHSKLQFEYQSLNTAMKTIQEMNQDLQSERDRLSAQVKALNGELSKLKAFKKQ 109
                 556666777666666555444699********************************************99988765 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 3.3
      DUF641   53 lselkrlyrkkqkkkaseaeeseleaeiqeqrsllktyeitvkk.leaelkakdsei 108 
                   s+ k++y+++  +++    e+  +a++++  +++kt     ++ l+a lk k+ ei
  EFC37278.1 2094 FSNCKHKYFDMLVDDQL---ENPNKANVDKILEMMKTNWLQESAlLNAVLKLKNDEI 2147
                  68899999999777754...4445555555555677665544431455556666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2590 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2299  (0.128228); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.48u 0.32s 00:00:01.80 Elapsed: 00:00:00.62
# Mc/sec: 12513.04
//
Query:       EFC37279.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2719  (0.151654); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.56
# Mc/sec: 1274.20
//
Query:       EFC37280.1  [L=148]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-15   57.9   0.0    2.2e-09   37.8   0.0    2.1  2  Ank_2     Ankyrin repeats (3 copies)
    1.9e-13   49.3   0.0     0.0092   16.4   0.0    3.3  3  Ank_3     Ankyrin repeat
    3.3e-12   46.7   0.0    6.2e-07   29.9   0.0    2.4  2  Ank_4     Ankyrin repeats (many copies)
      2e-07   31.1   0.0        0.8   10.3   0.0    3.4  3  Ank       Ankyrin repeat
    2.5e-06   27.6   0.0       0.33   11.3   0.0    3.1  3  Ank_5     Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.089   12.5   0.1        3.2    7.4   0.0    2.1  2  DCB       Dimerisation and cyclophilin-binding domain of Mon2


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.0   5.4e-07    0.0016      30      80 ..      17      73 ..       3      76 .. 0.68
   2 !   37.8   0.0   7.4e-13   2.2e-09      27      80 ..      78     134 ..      68     136 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 5.4e-07
       Ank_2 30 LhyAakngnleivklLle.h....adndgrtpLhyAarsghleivklLl.ekgadin 80
                L+ A+ ng+l+ v+ + + +    +++   +pL++A++  ++eivklLl  kg+++n
  EFC37280.1 17 LFDAIGNGDLKKVQSIKDiKlflyVNKGLGSPLFAACSTERTEIVKLLLsTKGVEVN 73
                566777776655555555313343666556999999988999999999954588877 PP

  == domain 2  score: 37.8 bits;  conditional E-value: 7.4e-13
       Ank_2  27 ktaLhyAakngnleivklLleh..ad.ndgrtpLhyAarsghleivklLlek.gadin 80 
                 k+aL+ A++ gnleivk+Lle   +  n+g ++L  A+ +ghleivk+L+e   +d+n
  EFC37280.1  78 KSALYGACETGNLEIVKMLLEIpgISlNKG-SALSRACMFGHLEIVKILMEMpSIDVN 134
                 79******************9777443555.7******************76578887 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   1.1e-05     0.031       4      30 ..      47      73 ..      46      73 .. 0.96
   2 !   16.4   0.0   3.1e-06    0.0092       4      30 ..      79     105 ..      76     106 .. 0.88
   3 !   14.4   0.0   1.4e-05     0.043       4      30 ..     108     134 ..     107     135 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.1e-05
       Ank_3  4 tpLhlAarsgnleivkfLlenkgadvn 30
                +pL+ A++  ++eivk+Ll  kg++vn
  EFC37280.1 47 SPLFAACSTERTEIVKLLLSTKGVEVN 73
                79**********************998 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 3.1e-06
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 ++L+ A++ gnleivk+Lle++g+ +n
  EFC37280.1  79 SALYGACETGNLEIVKMLLEIPGISLN 105
                 566669******************999 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 1.4e-05
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 ++L +A+++g+leivk L e + +dvn
  EFC37280.1 108 SALSRACMFGHLEIVKILMEMPSIDVN 134
                 799*****************8899998 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.9   0.0   2.1e-10   6.2e-07       3      55 .]      47      97 ..      46      97 .. 0.94
   2 !   14.4   0.0   1.5e-05     0.044       3      29 ..     108     135 ..     107     140 .. 0.91

  Alignments for each domain:
  == domain 1  score: 29.9 bits;  conditional E-value: 2.1e-10
       Ank_4  3 taLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklLl 55
                ++L++a++ +r+e+v+lLl++ g+++n+   ++  +al+ A+ +gn+ei+k+Ll
  EFC37280.1 47 SPLFAACSTERTEIVKLLLSTkGVEVNY---GYLKSALYGACETGNLEIVKMLL 97
                69******************989**999...57779*****************8 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.5e-05
       Ank_4   3 taLhyaaisgrlelvrlLlek.gadina 29 
                 +aL +a+++g+le+v++L e   +d+n+
  EFC37280.1 108 SALSRACMFGHLEIVKILMEMpSIDVNK 135
                 6899****************99999986 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.0   0.00027       0.8       4      28 ..      47      73 ..      47      75 .. 0.84
   2 !    7.8   0.0    0.0016       4.9       4      28 ..      79     105 ..      76     107 .. 0.78
   3 !    9.3   0.0   0.00055       1.7       4      22 ..     108     126 ..     108     136 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00027
                BHHHHHHHHTTHHHHHHHH..TTTSTT CS
         Ank  4 TPLHlAatngkkriiklLL..hGAnln 28
                +PL  A++   ++i+klLL  +G ++n
  EFC37280.1 47 SPLFAACSTERTEIVKLLLstKGVEVN 73
                59999**889999******85598887 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0016
                 BHHHHHHHHTTHHHHHHHH.T.TTSTT CS
         Ank   4 TPLHlAatngkkriiklLL.h.GAnln 28 
                 ++L  A+  g+++i+k+LL   G +ln
  EFC37280.1  79 SALYGACETGNLEIVKMLLeIpGISLN 105
                 567769989*********943666666 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00055
                 BHHHHHHHHTTHHHHHHHH CS
         Ank   4 TPLHlAatngkkriiklLL 22 
                 ++L +A+++g+++i+k L 
  EFC37280.1 108 SALSRACMFGHLEIVKILM 126
                 58999***********996 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.0    0.0045        13      18      43 ..      47      73 ..      39      75 .. 0.83
   2 !   11.3   0.0   0.00011      0.33       8      40 ..      71     102 ..      67     105 .. 0.78
   3 !    8.5   0.0   0.00085       2.5      15      39 ..     107     129 ..     101     134 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0045
       Ank_5 18 tpLhvAakygaadvvrlLl.argadln 43
                +pL  A++  + ++v+lLl   g+  n
  EFC37280.1 47 SPLFAACSTERTEIVKLLLsTKGVEVN 73
                78889**************88877665 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00011
       Ank_5   8 dvnrldgggntpLhvAakygaadvvrlLl.arga 40 
                  vn+   +  ++L  A++ g++++v++Ll  +g 
  EFC37280.1  71 EVNYGYLK--SALYGACETGNLEIVKMLLeIPGI 102
                 56666666..89999**************66665 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00085
       Ank_5  15 ggntpLhvAakygaadvvrlLlarg 39 
                 g  ++L  A+  g++++v++L++++
  EFC37280.1 107 G--SALSRACMFGHLEIVKILMEMP 129
                 3..89****************9443 PP

>> DCB  Dimerisation and cyclophilin-binding domain of Mon2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.0    0.0011       3.2      39      80 ..      26      65 ..       2      68 .. 0.71
   2 ?    3.4   0.0     0.018        54      63      81 ..      80      98 ..      71     134 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0011
         DCB 39 LktikssseeeeqslaeaseeilkPlllacetknpkivqiaL 80
                Lk+++s +  + + +++  + + +Pl+ ac+t  + iv++ L
  EFC37280.1 26 LKKVQSIK--DIKLFLYVNKGLGSPLFAACSTERTEIVKLLL 65
                44444444..22334444477889**************9877 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.018
         DCB 63 PlllacetknpkivqiaLg 81
                 l  acet n+ iv++ L+
  EFC37280.1 80 ALYGACETGNLEIVKMLLE 98
                57789**********9886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (148 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       301  (0.0167884); expected 358.6 (0.02)
Passed bias filter:                      244  (0.0136092); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 903.86
//
Query:       EFC37281.1  [L=648]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-49  169.3  20.3    1.9e-49  168.8  20.3    1.1  1  ABC_membrane  ABC transporter transmembrane region
    4.2e-35  121.2   0.0    8.3e-35  120.3   0.0    1.5  1  ABC_tran      ABC transporter
    6.8e-06   25.7   1.5     0.0023   17.4   1.5    2.4  1  SMC_N         RecF/RecN/SMC N terminal domain
    0.00031   21.1   0.0      0.001   19.5   0.0    1.8  1  AAA_16        AAA ATPase domain
     0.0012   18.5   0.2     0.0034   17.1   0.2    1.7  1  AAA_29        P-loop containing region of AAA domain
     0.0066   16.7   0.4       0.05   13.9   0.4    2.2  1  AAA_22        AAA domain
  ------ inclusion threshold ------
      0.015   15.7   0.1        0.6   10.5   0.1    2.5  1  AAA           ATPase family associated with various cellular 
      0.017   15.0   0.0       0.11   12.4   0.0    2.1  2  Rad17         Rad17 P-loop domain
      0.018   13.8   0.0      0.034   12.9   0.0    1.3  1  ABC_ATPase    Predicted ATPase of the ABC class
       0.02   14.6   0.0      0.075   12.7   0.0    1.8  1  AAA_30        AAA domain
      0.029   14.9   0.0      0.059   13.9   0.0    1.5  1  AAA_18        AAA domain
      0.035   13.4   0.0      0.081   12.2   0.0    1.5  1  Zeta_toxin    Zeta toxin
      0.039   13.9   0.0      0.091   12.7   0.0    1.6  1  RsgA_GTPase   RsgA GTPase
       0.04   13.7   0.0       0.63    9.8   0.0    2.2  2  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
      0.067   13.2   0.0       0.44   10.5   0.0    2.2  2  AAA_5         AAA domain (dynein-related subfamily)
       0.16   12.3   0.2       0.96    9.7   0.2    2.2  1  SbcCD_C       Putative exonuclease SbcCD, C subunit
       0.45   10.2   2.9         21    4.9   2.3    3.6  3  FeoB_C        Ferrous iron transport protein B C terminus
        4.3    7.5   7.9       0.27   11.3   2.5    1.8  1  DUF2614       Zinc-ribbon containing domain


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.8  20.3   1.9e-52   1.9e-49       1     266 [.      60     330 ..      60     340 .. 0.96

  Alignments for each domain:
  == domain 1  score: 168.8 bits;  conditional E-value: 1.9e-52
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHH.......HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHH CS
  ABC_membrane   1 liliillailagvlsplfplvlgrildtlldkgdpet.......ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpms 90 
                   l+l+i+ ++ +gv+ ++f +++g +++++  +++ +        ++++++s+ +++++++  +++++ +++l+++ e + + lr+ +f+++ rq+++
    EFC37281.1  60 LFLGIIGSLGNGVILLVFQFLFGDLINIFQADSNGNLpttekikSDISLISIKFTGVAIGGMAASFIAQFFLSWANELIGVSLRKAYFNALTRQDVG 156
                   6899*************************9986666677999******************************************************* PP

                   HHHHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane  91 ffdtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEsl 187
                   ffd +++G l+  l++dv+k+++++++kl+l++ +l +fv+gli++++++w+++lv+++++pl+++++++++k+++ l+ k +  ++k+ + a+E++
    EFC37281.1 157 FFDVKQTGALTIGLSEDVAKIQEAYTTKLSLIMSNLGMFVIGLILALISSWQMSLVMMSTVPLMLIITVILGKFTEILTGKSNIVISKSAAKATEVV 253
                   ************************************************************************************************* PP

                   HTHHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHH CS
  ABC_membrane 188 sgirtVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflsl 266
                   s ++tVk++g ee+++ +f + l++ +  +i +a ++g++i+  ++++   +alalw+G+ l  +g ++vgdlv  +++
    EFC37281.1 254 SSFKTVKSMGCEEKEQVNFANILKRLRLYAIIRASIQGVSISSENIISWGTIALALWYGGNLAADGVITVGDLV--KVF 330
                   ************************************************************************54..444 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  120.3   0.0   8.4e-38   8.3e-35       1     137 []     403     554 ..     403     554 .. 0.89

  Alignments for each domain:
  == domain 1  score: 120.3 bits;  conditional E-value: 8.4e-38
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.........HHHTCHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.........esdeeiekals 90 
                 lk+ sl+++ g+ +a+vG++G+GKSt++ ll + ++p+eGei +dg ++ke++ ++l+k +g+++qep lf    +ren           +++ie+a++
  EFC37281.1 403 LKDFSLDIRVGQSIALVGPSGSGKSTIVGLLERYYDPQEGEIFIDGVNIKEIDPQWLHKYVGIVTQEPVLFAMN-IRENlayaigienVTQDQIEQAAK 500
                 7999********************************************************************99.***********9944444444444 PP

                 HSTTGG.......TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  91 klglke.......lkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                   + ++         dt +++++ sLSgGqkqr+a+arall++pk+lllDE+t+
  EFC37281.1 501 AANCHNfilelpnGYDTMLGEKGVSLSGGQKQRIAIARALLQNPKILLLDEATS 554
                 44444444444446699***********************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   1.5   2.4e-06    0.0023     135     213 ..     468     598 ..     400     603 .. 0.73

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 2.4e-06
                 T........................................................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHH CS
                 x........................................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 135 e........................................................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvk 177
                 +                                                        +LSgG+k+ +a+a        +   + llDe  +aLD +  +
  EFC37281.1 468 QepvlfamnirenlayaigienvtqdqieqaakaanchnfilelpngydtmlgekgvSLSGGQKQRIAIARA----LLQNPKILLLDEATSALDTESEA 562
                 4455555555555555555555555555555555555555888888888888888889*******9888754....345556899************** PP

                 HHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 178 kvaellkeksknaQfivislreemlekadklvgvtk 213
                  v   l++  k    + i++r  +++++d ++ + k
  EFC37281.1 563 LVQAALETLMKGRTSVSIAHRLSTVQNCDVIYVLAK 598
                 *****************************9987665 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0     1e-06     0.001      25     161 ..     414     570 ..     406     581 .. 0.55

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1e-06
      AAA_16  25 elvllsGesGvGKsslvrellralekd.....................ggiflrgkcdqlesaipysalaqalareellrqllde.......aesaele 95 
                 +++ l+G+sG+GKs++v  l r++  +                     ++  ++++ + + ++i          re l  +++ e       +++a+++
  EFC37281.1 414 QSIALVGPSGSGKSTIVGLLERYYDPQegeifidgvnikeidpqwlhkYVGIVTQEPVLFAMNI----------RENLAYAIGIEnvtqdqiEQAAKAA 502
                 6899******************999997666666666666666666543444555555553332..........2222222222211111222223344 PP

      AAA_16  96 awrekleeala........avpelagaeasrllellkrllallsrderplvlvlDdlq.wadeaslqllaaLlrl 161
                   + +++e  +         + +l+g +++r++ +  r+l  l   + p +l+lD++   +d++s +l +a l++
  EFC37281.1 503 NCHNFILELPNgydtmlgeKGVSLSGGQKQRIAIA--RAL--L---QNPKILLLDEATsALDTESEALVQAALET 570
                 44444444444444555444444444444444333..333..2...55778888888855566666666665554 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.2   3.4e-06    0.0034      17      39 ..     408     430 ..     400     433 .. 0.83

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3.4e-06
      AAA_29  17 ieidlkgatlltGpsGsGKSTll 39 
                 ++i++ +++ l+GpsGsGKST++
  EFC37281.1 408 LDIRVGQSIALVGPSGSGKSTIV 430
                 566666689************97 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.4     5e-05      0.05       5     112 ..     413     571 ..     410     597 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 5e-05
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaee..............erpevvfvtlpsstsskdllrellralglelka................... 70 
                  ++++++G+sG+GK+t +  l + +d ++                  ++   +  + p++    +++++l+ a+g e+ +                   
  EFC37281.1 413 GQSIALVGPSGSGKSTIVGLLERYYDPQEGEIFidgvnikeidpqwlHKYVGIVTQEPVLF-AMNIRENLAYAIGIENVTqdqieqaakaanchnfile 510
                 6799************988777777644333335567777776666544444455555555.6666666666666666666666666667777777777 PP

      AAA_22  71 ..............erlsseell.ealeqalrarav...ielliiDEaqh.lr..s....eealeeL 112
                               +      l   + ++ + ara    +++l++DEa   l+  s    ++ale+L
  EFC37281.1 511 lpngydtmlgekgvS------LSgGQKQRIAIARALlqnPKILLLDEATSaLDteSealvQAALETL 571
                 666666664322221......2223333333333334455577777777766654244555555555 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.1    0.0006       0.6       2      98 ..     417     577 ..     416     597 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.0006
                 EEESSTTSSHHHHHHHHHHHH..........THEEEEEETTTCSSS..................................................... CS
         AAA   2 llyGppGtGKTllakavakel..........gvefleisgsellsk..................................................... 37 
                  l+Gp G GK++++  + +            gv++ ei+   l  k                                                     
  EFC37281.1 417 ALVGPSGSGKSTIVGLLERYYdpqegeifidGVNIKEIDPQWLH-Kyvgivtqepvlfamnirenlayaigienvtqdqieqaakaanchnfilelpng 514
                 58899999999999888888644333333333444444433333.245666666666666666666667777777777777778888888888888888 PP

                 .........STTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  38 .........yvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkk 98 
                          +   + +k r  +++a  ++ p+il++DE+ +   ++      +e  v+++L t ++g ++
  EFC37281.1 515 ydtmlgekgVSLSGGQKQRIAIARALLQN-PKILLLDEATSALDTE------SEALVQAALETLMKGRTS 577
                 88866666544455556666666655555.99******99999999......777888888888888776 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   0.00011      0.11      35      88 ..     403     457 ..     400     517 .. 0.83
   2 ?   -0.6   0.0       1.1   1.1e+03     128     170 ..     539     582 ..     522     593 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00011
       Rad17  35 lkadvLesrkkriLLisGPsGCgkstvvkvLskelgiklre.wlnpvslkepdnq 88 
                 lk  +L+ r  + + + GPsG gkst+v  L + + ++  e ++++v++ke d q
  EFC37281.1 403 LKDFSLDIRVGQSIALVGPSGSGKSTIVGLLERYYDPQEGEiFIDGVNIKEIDPQ 457
                 55566777777778899*****************999987746899999998765 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.1
       Rad17 128 dlrtdkklilvedlPnkfyrdsdalrevirkylrssea.lplil 170
                  l  + k++l+++  +   ++s+al +  ++ l+ +++ +++  
  EFC37281.1 539 ALLQNPKILLLDEATSALDTESEALVQAALETLMKGRTsVSIAH 582
                 55678899**************9987776666665554046555 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   3.4e-05     0.034     299     353 ..     501     556 ..     493     595 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.4e-05
                 EE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS-H CS
  ABC_ATPase 299 gvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsAt 353
                  ++  +Fi +LP+g dt         SG   q  +i++al  + k+lL+DE tsA 
  EFC37281.1 501 AANCHNFILELPNGYDTMlGEKGVSLSGGQKQRIAIARALLQNPKILLLDEATSAL 556
                 678899***********965566678****************************95 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   7.5e-05     0.075      22     114 ..     417     569 ..     411     578 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 7.5e-05
      AAA_30  22 vltGpAGtGKttalkalreaweaa.g.........................grviglAptgkaAkvLaeelgieastiakllkrlk............. 81 
                 +l+Gp G+GK+t+++ l++ ++ + g                         ++ +++A + +  ++La ++gie  t +++ ++ k             
  EFC37281.1 417 ALVGPSGSGKSTIVGLLERYYDPQeGeifidgvnikeidpqwlhkyvgivtQEPVLFAMNIR--ENLAYAIGIENVTQDQIEQAAKaanchnfilelpn 513
                 799**************999998856888888777777777776655555533344444333..34444555544444444433334455556666669 PP

      AAA_30  82 .......................grarlepgtllivDEagmvdtkqlaallkaaek 114
                                        +ra l++ ++l+ DEa  +  ++ +al++aa +
  EFC37281.1 514 gydtmlgekgvslsggqkqriaiARALLQNPKILLLDEATSALDTESEALVQAALE 569
                 99999999999999999999988767777889999999988877788888887765 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0     6e-05     0.059       1      78 [.     416     508 ..     416     512 .. 0.59

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 6e-05
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf..........gvnlrdva..kenglllevdpe......aldeskrldedkldklldaleenssaleegknlv 78 
                 I+l G++G+GK+t+   L++   +          gvn++++   + + ++  v++e       ++e++   ++  ++ +d++e++++  ++++n +
  EFC37281.1 416 IALVGPSGSGKSTIVGLLERY--YdpqegeifidGVNIKEIDpqWLHKYVGIVTQEpvlfamNIRENLAYAIGIENVTQDQIEQAAK-AANCHNFI 508
                 89****************554..3555655566755555553113333333333335566655666666666666666666666554.55555555 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   8.1e-05     0.081      18      61 ..     415     458 ..     411     479 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 8.1e-05
  Zeta_toxin  18 lillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPey 61 
                 +i l+G +G+GKs++  ll+++ ++q++ + +d+ +++e  P+ 
  EFC37281.1 415 SIALVGPSGSGKSTIVGLLERYYDPQEGEIFIDGVNIKEIDPQW 458
                 57899********************************9999874 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   9.2e-05     0.091      99     124 ..     413     438 ..     373     447 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 9.2e-05
                  TSEEEEECSTTSSHHHHHHHHCTT-- CS
  RsgA_GTPase  99 dktsvlvGqSGvGKStLinallpele 124
                  ++ ++lvG+SG GKSt++  l    +
   EFC37281.1 413 GQSIALVGPSGSGKSTIVGLLERYYD 438
                  48899*************99876555 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00064      0.63       3      23 ..     417     437 ..     415     463 .. 0.73
   2 ?    1.3   0.0      0.24   2.4e+02     236     271 ..     525     557 ..     507     583 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00064
      AAA_21   3 vliGpNgsGKSnLLdaldlla 23 
                 +l+Gp gsGKS++  +l+   
  EFC37281.1 417 ALVGPSGSGKSTIVGLLERYY 437
                 89***********99998764 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.24
      AAA_21 236 elSdGtkrllalltallralkkgsllliDEpEngLH 271
                 +lS G+k+ +a++ all+ +   ++ll+DE  + L+
  EFC37281.1 525 SLSGGQKQRIAIARALLQNP---KILLLDEATSALD 557
                 57999999989999999888...9******777776 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00044      0.44       3      24 ..     417     439 ..     415     446 .. 0.82
   2 ?   -0.5   0.0       1.1   1.1e+03      63      80 ..     541     558 ..     514     610 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00044
                 EEE--SSSSHHHHHHHGGGGB.S CS
       AAA_5   3 lLvGppGtgKselaerlaaal.n 24 
                  LvGp+G+gKs+++  l + +  
  EFC37281.1 417 ALVGPSGSGKSTIVGLLERYYdP 439
                 69*************99987754 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.1
                 --G-SEEEEESGGG--HH CS
       AAA_5  63 aregeilvlDEveraese 80 
                  ++++il+lDE + a + 
  EFC37281.1 541 LQNPKILLLDEATSALDT 558
                 348899999998876543 PP

>> SbcCD_C  Putative exonuclease SbcCD, C subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.2   0.00096      0.96      32      86 ..     525     566 ..     496     570 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00096
     SbcCD_C  32 tlSGGekqflaylalaaalaalyssaegrepalrlvfLDEAFsklDeesiatlle 86 
                 +lSGG+kq    +a+a   +al+       +++++++LDEA s lD es a + +
  EFC37281.1 525 SLSGGQKQR---IAIA---RALL-------QNPKILLLDEATSALDTESEALVQA 566
                 566666633...2222...2222.......3489*************98776655 PP

>> FeoB_C  Ferrous iron transport protein B C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0         1     1e+03      23      35 ..      20      33 ..      17      35 .. 0.86
   2 ?    4.9   2.3     0.021        21       2      22 ..     192     212 ..     192     237 .. 0.85
   3 ?    0.3   0.0      0.59   5.8e+02      29      37 ..     505     513 ..     499     513 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1
      FeoB_C 23 t.lkgepspfvmEL 35
                  +k+++  f mEL
  EFC37281.1 20 NpFKKKKNDFSMEL 33
                45999********9 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.021
      FeoB_C   2 fslYllgilvallvalllkkt 22 
                 ++++++g+++al++++ ++ +
  EFC37281.1 192 LGMFVIGLILALISSWQMSLV 212
                 589*************99874 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.59
      FeoB_C  29 spfvmELPp 37 
                   f++ELP+
  EFC37281.1 505 HNFILELPN 513
                 57******7 PP

>> DUF2614  Zinc-ribbon containing domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   2.5   0.00028      0.27       4      83 ..     175     256 ..     172     271 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00028
     DUF2614   4 skinkirtfalllvfiglivmyigllfk.eselllvlflllGl.llvlastvvyfwiGllstkavqvvcpeceketkvlGrv 83 
                 +ki+ + t  l+l++  l ++ igl++   s++ ++l+++  + l++++++++  +  +l+ k+ +v+  +  k t v+   
  EFC37281.1 175 AKIQEAYTTKLSLIMSNLGMFVIGLILAlISSWQMSLVMMSTVpLMLIITVILGKFTEILTGKSNIVISKSAAKATEVVSSF 256
                 6999999*****************776526789999998877647888888899999*******************998754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (648 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1056  (0.058899); expected 358.6 (0.02)
Passed bias filter:                      593  (0.0330749); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              18  [number of targets reported over threshold]
# CPU time: 0.79u 0.37s 00:00:01.16 Elapsed: 00:00:00.54
# Mc/sec: 3622.87
//
Query:       EFC37282.1  [L=489]
Description: hypothetical protein NAEGRDRAFT_81991 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.8e-07   28.9  10.9    1.5e-06   28.2  10.9    1.4  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2  10.9   8.2e-11   1.5e-06       2      39 ..      18      55 ..      17      56 .. 0.90

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 8.2e-11
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                +C+ Cr+++++C++ kP+C +C+ +++eC + s ++k+
  EFC37282.1 18 SCQFCRSQHRRCSKTKPSCYSCVMRGVECIYGSGKRKK 55
                8*****************************66666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1238  (0.0690501); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2940.36
//
Query:       EFC37283.1  [L=543]
Description: hypothetical protein NAEGRDRAFT_81993 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.4e-09   35.4  34.5    8.2e-05   22.3   1.6    7.6  8  MORN        MORN repeat
    2.9e-06   28.2   1.2    5.8e-06   27.2   1.2    1.5  1  CS          CS domain
  ------ inclusion threshold ------
       0.43    9.3   3.0       0.79    8.4   3.0    1.5  1  Presenilin  Presenilin
        1.1    8.9  17.6         11    5.7   2.2    4.0  4  FAM176      FAM176 family


Domain annotation for each model (and alignments):
>> MORN  MORN repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1     0.014        63      10      22 ..     337     349 ..     336     350 .. 0.89
   2 !    5.6   0.1    0.0036        16       1      18 [.     351     368 ..     351     370 .. 0.94
   3 !   22.3   1.6   1.8e-08   8.2e-05       1      23 []     412     434 ..     412     434 .. 0.98
   4 ?    3.3   0.1     0.019        85      10      23 .]     445     458 ..     435     458 .. 0.81
   5 !   19.1   0.1   1.9e-07   0.00083       1      19 [.     459     477 ..     459     481 .. 0.95
   6 ?    2.5   0.6     0.036   1.6e+02       2       9 ..     484     491 ..     484     492 .. 0.88
   7 ?   -2.3   0.3       1.2   5.3e+03       5       9 ..     499     503 ..     495     504 .. 0.72
   8 ?   -2.5   0.1       1.3     6e+03       2       6 ..     533     537 ..     533     538 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.014
        MORN  10 rhGkGvytwpdGd 22 
                 rhG+G  ++p+ d
  EFC37283.1 337 RHGFGSAYYPNDD 349
                 8*********977 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0036
        MORN   1 YeGeWknGkrhGkGvytw 18 
                 Y+G++ n  r+G G y++
  EFC37283.1 351 YIGTFDNTIREGMGAYIY 368
                 9*************9998 PP

  == domain 3  score: 22.3 bits;  conditional E-value: 1.8e-08
        MORN   1 YeGeWknGkrhGkGvytwpdGdr 23 
                 Y G+Wk+++++GkG++ + +Gdr
  EFC37283.1 412 YVGDWKKNMKNGKGRMLYHNGDR 434
                 99*******************97 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.019
        MORN  10 rhGkGvytwpdGdr 23 
                  +  G+y +++Gd+
  EFC37283.1 445 QCERGIYLYSNGDM 458
                 5668********96 PP

  == domain 5  score: 19.1 bits;  conditional E-value: 1.9e-07
        MORN   1 YeGeWknGkrhGkGvytwp 19 
                 Y Ge+k++ + GkGvyt++
  EFC37283.1 459 YVGEFKDDHKTGKGVYTFA 477
                 99****************8 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.036
        MORN   2 eGeWknGk 9  
                 +GeWk+Gk
  EFC37283.1 484 DGEWKEGK 491
                 6******9 PP

  == domain 7  score: -2.3 bits;  conditional E-value: 1.2
        MORN   5 WknGk 9  
                 Wk+Gk
  EFC37283.1 499 WKDGK 503
                 88877 PP

  == domain 8  score: -2.5 bits;  conditional E-value: 1.3
        MORN   2 eGeWk 6  
                 +G+Wk
  EFC37283.1 533 DGQWK 537
                 6***8 PP

>> CS  CS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   1.2   1.3e-09   5.8e-06       2      74 ..       9      84 ..       8      88 .. 0.90

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 1.3e-09
                SCEEEEETTEEEEEEE-TTCTTTTTCEEEEEETTEEEEEE...TS.CEEEEECEBSS-BETTTEEEEEETTEEEEEE CS
          CS  2 kydWyQtldeVvvtiyvkkvnikkkdvkvefkerslkvki...gk.eklliegeLfgpIdpeesswtieskkveitL 74
                +y++ Qt++ ++v+++ ++ +  ++d++v++  ++l++ +   g+ e+ l+e+ L + ++p++  w++ ++k  i+L
  EFC37283.1  9 NYTFKQTKNAITVELPSPE-DLVQEDIDVSIVGKKLSIVVrkpGEdEEKLLEDTLHEAVNPNSLDWKLDTNKWRISL 84
                79*****************.9**************9999988977777777777***************98877777 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   3.0   0.00018      0.79     240     331 ..     206     368 ..     168     406 .. 0.63

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00018
  Presenilin 240 eaekkkeeasesskeeeseeesseksaqsse........................................seeeseeesseaessaeesseekesees 298
                 ++ +  e+++++ ke+++eee++e+++  ++                                        +ee  +ee +e++ +++e+seek+++ +
  EFC37283.1 206 RRLHLLEKKQNEPKESTEEEEEPEEEKDFASglvekfekytvelikqigeygiyegetaefeipveippvvEEEPPKEEPKEEPPTTDENSEEKNEDDN 304
                 22222222222222222222222222222225556677788889999999******9999999999999874444444444444444444444444444 PP

  Presenilin 299 sesseeeeeeeeeeeeses................................eergvkLGLGDFiF 331
                 ++++++e +e   e++ ++                                 +++++ G+G +i+
  EFC37283.1 305 ENNDDDEPKEP-VEKKPKKvkvveppkpiivkyrhgfgsayypnddvyigtFDNTIREGMGAYIY 368
                 43333333333.33332334566677777777777777666666666655544688888887775 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.12   5.3e+02      39      87 ..      98     147 ..      96     169 .. 0.45
   2 ?    4.8   1.6    0.0045        20      49      83 ..     203     233 ..     190     265 .. 0.51
   3 ?    5.7   2.2    0.0024        11      59      85 ..     286     313 ..     268     332 .. 0.42
   4 ?    5.1   1.0    0.0037        16      60      86 ..     375     401 ..     368     424 .. 0.62

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.12
      FAM176  39 cllviriscrkdlerlkkkkkklkeeseka.sededeeeeeeeedssese 87 
                 +++vi+i    ++  ++k ++  k  +e + +ed  ++ +++  ++s+s+
  EFC37283.1  98 FVVVINIPPVFQFADENKVNEVIKIFKEAKrKEDGGDDGDDSGGSTSSSH 147
                 45555555554444333333333333222224444444444333333333 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0045
      FAM176  49 kdlerlkkkkkklkeesekasededeeeeeeeeds 83 
                 k+ +rl+  +kk++e +    e+++eeee eee++
  EFC37283.1 203 KEKRRLHLLEKKQNEPK----ESTEEEEEPEEEKD 233
                 33333333333333333....22222222222222 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0024
      FAM176  59 kklkeesekaseded.eeeeeeeedsse 85 
                 k++ ++++++se+++ +++e++++d+ +
  EFC37283.1 286 KEEPPTTDENSEEKNeDDNENNDDDEPK 313
                 1111222222222220222222222222 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0037
      FAM176  60 klkeesekasededeeeeeeeedsses 86 
                 +l+e++ek++e++dee++ + e ++e+
  EFC37283.1 375 QLREKKEKEQEEKDEEDDGNAEGDEEA 401
                 444555555555555555444444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (543 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1260  (0.0702772); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.79u 0.34s 00:00:01.13 Elapsed: 00:00:00.54
# Mc/sec: 3040.43
//
Query:       EFC37284.1  [L=872]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (872 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       601  (0.0335211); expected 358.6 (0.02)
Passed bias filter:                      256  (0.0142785); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.50
# Mc/sec: 5266.23
//
Query:       EFC37285.1  [L=663]
Description: RNA-directed RNA polymerase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   3.3e-133  445.4   0.1   4.2e-133  445.1   0.1    1.1  1  RdRP      RNA dependent RNA polymerase


Domain annotation for each model (and alignments):
>> RdRP  RNA dependent RNA polymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  445.1   0.1  2.3e-137  4.2e-133     108     585 ..       1     456 [.       1     457 [. 0.91

  Alignments for each domain:
  == domain 1  score: 445.1 bits;  conditional E-value: 2.3e-137
        RdRP 108 lgdfenisqsvaKyaaRlglalSttrptvvkvereqiiieeidDv.kneekdiylftDGvGliSrelarkiakklglkkaeelPsafQiRigGaKGvla 205
                 +gdf++i +++aK+aaR+g++l++t+p+ +++ ++   ie ++D+ +n+     +ftDG+G+iS+e+++++ +kl+l   e l sa+Q+R+gG KGvla
  EFC37285.1   1 MGDFTDI-KTPAKVAARFGQCLTSTTPS-IEITKD---IEPVEDIeRNG----FTFTDGIGKISEEMMQRVKEKLQLG--ESLLSAIQFRCGGGKGVLA 88 
                 79**999.*******************8.888866...7899**96766....68**********************8..8899*************** PP

        RdRP 206 vdkrlkpekielrpSqiKfkseeddsekrtleivkvsskpkpayLnrqlikiLedlgvpeevflellkealeelrealkdagaaaellkkagdpsklee 304
                 +d++lk e+i +r+Sq Kf s      +++leiv++s+++ + +Lnrq+i+iL  lg+++e+f+  ++e+++++ ++++d+++a+e l+ +  ++++  
  EFC37285.1  89 IDPTLKGEQIVFRKSQFKFTSI-----QKQLEIVDYSKRR-SGFLNRQFITILTALGIKDEIFMTKQREMIRSILSITDDVSKAYEWLSIYH-SNHTRT 180
                 *****5589**********554.....456**********.***********************************************6443.577888 PP

        RdRP 305 llaelldsgfdpseldpflrsllkalvkeslrklkekarIpvpksatllgvaDetgvLkegevfvqlse.aldqedeksktkllkgdvlVtRnPalhpg 402
                 ++ ++l+   +  ++++f++++l+ + ++ l+ l++k +I ++ksa+l+g +De+gvL+e+e+fv+ls  +    +   +  ++kg+++V +nP+lh g
  EFC37285.1 181 FICHVLKYVPEIATSENFIMNMLSSYKEQLLKGLRDKTKIYIEKSAYLMGAIDEYGVLEENEIFVNLSPiFHRP-NA--EFGVVKGRCIVGKNPSLHKG 276
                 8888888888888889****************************************************976333.33..4889**************** PP

        RdRP 403 DiqvvkavdvpelrhlkdviVFstkGdrslaselsGGDlDGDkywViwdpelefapakpsneepadyee.........akpkeldrevtvediadffve 492
                 D ++v+avd pel hl dv+VFs+kG+r++ +++ G+DlDGD+++V+wdp+l+  p+  +  ep+dy+          ++++e + +++++di dff+e
  EFC37285.1 277 DLRIVTAVDRPELYHLNDVVVFSKKGKRPITNMITGSDLDGDQFFVYWDPDLI--PE-SD-SEPMDYSVgavakptnkKDEEEEEYKIKQDDIIDFFIE 371
                 ********99******************************************6..55.34.56******9999987531333334557888******** PP

        RdRP 493 ymksdvlGlisnahlaiadq.eegiddpkclkLaelhskaVDypKtGipvdkkeiprelkkpkekPdfkekekkekakkpyykskkilgkLyre 585
                 ++++++lGli+n hla +d  ++g+++++cl L elhs+aVD++K+G  +    ip++  k  e+P+f+ ++      k+ ykskk+lgkL++e
  EFC37285.1 372 FITRNNLGLIANTHLANSDFrKNGLTSKECLTLCELHSTAVDSAKSGKFAI---IPSKV-KLYEYPHFMISSM-----KRKYKSKKVLGKLFDE 456
                 *******************99*****************************9...99988.6899*****8775.....345***********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (663 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       900  (0.050198); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 3855.35
//
Query:       EFC37286.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.08   11.5   5.2      0.072   11.6   5.2    1.1  1  Macoilin    Macoilin family
        1.3    7.7   2.8        1.3    7.7   2.8    1.1  1  Presenilin  Presenilin
        9.4    6.3  11.1         14    5.7  11.1    1.3  1  NST1        Salt tolerance down-regulator


Domain annotation for each model (and alignments):
>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   5.2   1.2e-05     0.072     313     374 ..      17      84 ..       1     176 [. 0.58

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.2e-05
    Macoilin 313 eesvkskssssssssnknskkasagsagssnssskkhsessksvtsssssknskkq......klpaGk 374
                 ++  +++ s++ sss++n +++s+++ +  +s+s + +++s+s++ sss+++s  +      ++ +G+
  EFC37286.1  17 RGGKTNRVSTNVSSSSNNVNTNSGTQQSNNSSASSSSNTQSSSPPPSSSNAQSVGRggnsrgRGRGGN 84 
                 22223333333333333333333322222222222333334444434333332222122111222333 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   2.8   0.00022       1.3     243     297 ..      10      66 ..       1     136 [. 0.51

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00022
  Presenilin 243 kkkeeasesskeeeseeesseksaqsse..seeeseeesseaessaeesseekesee 297
                 ++++++ +  k+++ +++ s++s++ ++   +++s+++s++++s++++ss + +s++
  EFC37286.1  10 HSQQNNPRGGKTNRVSTNVSSSSNNVNTnsGTQQSNNSSASSSSNTQSSSPPPSSSN 66 
                 222222222222222222222222211110222222222222222222222222111 PP

>> NST1  Salt tolerance down-regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7  11.1    0.0024        14      18      85 ..       3      68 ..       1      96 [. 0.63

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0024
        NST1 18 dknevdeksqvesskrkkkkkkkkknrsnsnnqneesstslstsksvaittssarsvknnppsvssaa 85
                ++++ +++sq+++ +  k ++ +    s+snn+n++s t++s+++  a ++s+++s + + ps+s+a+
  EFC37286.1  3 NNRNRPHHSQQNNPRGGKTNRVSTNVSSSSNNVNTNSGTQQSNNS-SASSSSNTQSSSPP-PSSSNAQ 68
                555666666666666666666677777778888888888888887.55556666666633.3333232 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1376  (0.0767472); expected 358.6 (0.02)
Passed bias filter:                      599  (0.0334096); expected 358.6 (0.02)
Passed Vit filter:                       102  (0.00568911); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.36s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 1383.13
//
Query:       EFC37287.1  [L=550]
Description: hypothetical protein NAEGRDRAFT_81994 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0027   17.1   0.0     0.0042   16.4   0.0    1.2  1  ART             NAD:arginine ADP-ribosyltransferase
  ------ inclusion threshold ------
       0.12   11.7   0.0       0.22   10.9   0.0    1.3  1  ADPrib_exo_Tox  ADP-ribosyltransferase exoenzyme


Domain annotation for each model (and alignments):
>> ART  NAD:arginine ADP-ribosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   4.7e-07    0.0042      61     204 ..      79     217 ..      51     224 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 4.7e-07
         ART  61 fkdehgiAllaYtss.selyrelneavrea.GrsreeylsnfdfkalhfyLtraLqlLrkdsqrcsqvyRgvkglrfsrakkgksvRfgqFtssslkkk 157
                 ++ e+   + aY ++  +ly  ln +++ +  +sr  ++++     +   L  aL++L k      + +Rg+   ++   k g+      F s+s + +
  EFC37287.1  79 INYEDYRNIYAYKAEyPRLYPLLNCHLKVTpNNSRPGWVHD-----FSTGLNVALKKLVK---YEFETFRGTGLDNI--PKIGDLLQNSGFLSTSKSAH 167
                 555555668999999889********996313455555555.....5568999*****99...44578999984444..488999************** PP

         ART 158 vae.efgqdtllsiktclgvpIkef..skfpsedevLIppfevFkvtnls 204
                 va+ +  +  ++    + g +I  +  + f++e ev++pp + F+v+ + 
  EFC37287.1 168 VASgFASNRYMFRFSKSGGRDITGVegLPFQGELEVIVPPGKCFRVIAMG 217
                 99944456789***********98833568899*************9865 PP

>> ADPrib_exo_Tox  ADP-ribosyltransferase exoenzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   2.4e-05      0.22     109     172 ..     154     216 ..     149     232 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 2.4e-05
                     EEESS-EEEESSSS.SCCCTTTSEEEEEEE-TTSBEEE-CCCSSSGCG-EEEE-TTEEEEEEEE CS
  ADPrib_exo_Tox 109 fkergyvSTslvkdtaasfggreilleltvpkgsegayisplslypgeaEvLlprgltykinki 172
                      ++ g++STs +  +a++f+ ++ +++++ + g+    +++l  ++ge Ev++p g  +++  +
      EFC37287.1 154 LQNSGFLSTSKSAHVASGFASNRYMFRFSKSGGRDITGVEGLP-FQGELEVIVPPGKCFRVIAM 216
                     5789*************************99999999999996.79********9999998655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (550 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 3204.94
//
Query:       EFC37288.1  [L=478]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-53  176.4  29.3    1.1e-13   50.6   0.2   10.6 13  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.058   11.4   0.0       0.12   10.3   0.0    1.5  1  MTTB      Trimethylamine methyltransferase (MTTB)
       0.26   11.2   2.7         16    5.3   0.1    3.5  4  Rad17     Rad17 P-loop domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.2   0.00035       2.1       3      41 ..      17      55 ..      15      63 .. 0.84
   2 !   10.1   0.0   8.9e-05      0.53      22      49 .]      60      89 ..      57      89 .. 0.89
   3 !   10.8   0.0   5.3e-05      0.32       1      29 [.      64      94 ..      64      98 .. 0.89
   4 ?    0.2   0.0      0.11   6.3e+02       3      19 ..     127     143 ..     124     146 .. 0.60
   5 !   43.4   0.8   3.3e-15     2e-11       1      37 [.     149     185 ..     149     200 .. 0.93
   6 !    7.8   0.0   0.00045       2.7      19      45 ..     196     222 ..     188     226 .. 0.87
   7 !   21.4   0.2   2.6e-08   0.00015       1      48 [.     203     250 ..     203     251 .. 0.95
   8 !   24.8   0.1   2.2e-09   1.3e-05       1      49 []     228     276 ..     228     276 .. 0.95
   9 !   50.6   0.2   1.9e-17   1.1e-13       1      49 []     278     326 ..     278     326 .. 0.97
  10 !   19.4   0.1     1e-07   0.00062       1      36 [.     303     338 ..     303     347 .. 0.95
  11 !   12.7   0.1   1.3e-05      0.08       1      43 [.     350     393 ..     350     401 .. 0.87
  12 !   22.4   1.0   1.2e-08   7.2e-05       1      44 [.     402     446 ..     402     451 .. 0.90
  13 ?   -1.4   0.0      0.34   2.1e+03       4      22 ..     455     474 ..     454     475 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00035
     DUF4116  3 EivleavkkngsalkylseeLknDkeivlkAvkqngtal 41
                E++l  ++ n ++   +s+e++ ++ + l+ ++  +  +
  EFC37288.1 17 EFALLHIRENYFHMSRFSKEIRDNRKFKLAVIRERPADI 55
                999999*********************999999877433 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 8.9e-05
     DUF4116 22 eLknDkeivlkAvkqng..talsyaseeLr 49
                +L +D+e +l A+ q g  ++l++as eLr
  EFC37288.1 60 DLLSDREAILLAISQPGfgYILERASVELR 89
                6899***********88668******9998 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 5.3e-05
     DUF4116  1 DrEivleavkkn..gsalkylseeLknDkei 29
                DrE +l a+++   g++l+ +s eL+ D e+
  EFC37288.1 64 DREAILLAISQPgfGYILERASVELRLDSEL 94
                9***********5555************996 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.11
     DUF4116   3 Eivleavkkngsalkyl 19 
                  iv + +++ng +++ l
  EFC37288.1 127 RIVRKMLSRNGDYFEIL 143
                 46666666666666544 PP

  == domain 5  score: 43.4 bits;  conditional E-value: 3.3e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 D E++l a+k ++sa++++s+eLk+Dk+++lkA+k+ 
  EFC37288.1 149 DCELALIAIKDDPSAIYFISDELKRDKDFILKAIKSR 185
                 89*********************************85 PP

  == domain 6  score: 7.8 bits;  conditional E-value: 0.00045
     DUF4116  19 lseeLknDkeivlkAvkqngtalsyas 45 
                 l+e + nD++++l++ kqn + l +a 
  EFC37288.1 196 LPEYWGNDRQVLLEIGKQNYHLLQFAE 222
                 788888*****************9985 PP

  == domain 7  score: 21.4 bits;  conditional E-value: 2.6e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 Dr++ le+ k+n   l+++  +++ D e+v++ ++   ++l+ ++e +
  EFC37288.1 203 DRQVLLEIGKQNYHLLQFAEYNWREDDEFVMEMIREKTIILEDIPERF 250
                 99****************************************999976 PP

  == domain 8  score: 24.8 bits;  conditional E-value: 2.2e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D E+v+e ++    +l+ ++e++k  + +vl+ vk++g+al+ +s ++r
  EFC37288.1 228 DDEFVMEMIREKTIILEDIPERFKTERHLVLELVKNCGIALRVLSSDMR 276
                 669***************************************9998876 PP

  == domain 9  score: 50.6 bits;  conditional E-value: 1.9e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivlea+k+ +sa++++se+LknD+ei++ A++ +++++ +++ +++
  EFC37288.1 278 DREIVLEAIKNLPSAYQFASENLKNDIEIIKTALQLSSIVFHMIPSHFK 326
                 9*****************************************9998875 PP

  == domain 10  score: 19.4 bits;  conditional E-value: 1e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 D Ei++ a++  + +++ +++ +kn  e+vl A+k+
  EFC37288.1 303 DIEIIKTALQLSSIVFHMIPSHFKNENEFVLMALKS 338
                 89********************************96 PP

  == domain 11  score: 12.7 bits;  conditional E-value: 1.3e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq.ngtalsy 43 
                 +r++vl+++k+  + +  ++ e+ +D+ei+   +k+ ng +++y
  EFC37288.1 350 NRDFVLQVCKIGKMPFSAIPLEFISDFEIIGTVIKNmNGRNFKY 393
                 8**********88888889***********99999548888876 PP

  == domain 12  score: 22.4 bits;  conditional E-value: 1.2e-08
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsya 44 
                 ++ i l++++   ++ + +l++eL+nD e++l+ vk ng++l  +
  EFC37288.1 402 NKNILLKLIEFIsPKLIIFLPPELSNDMEFLLEYVKFNGDFLLKI 446
                 7899******77589************************999766 PP

  == domain 13  score: -1.4 bits;  conditional E-value: 0.34
     DUF4116   4 ivleavkkngsalky.lsee 22 
                 +++++++ n+  ++y ls++
  EFC37288.1 455 FITNVLEVNWQTFQYtLSKN 474
                 8999***********88876 PP

>> MTTB  Trimethylamine methyltransferase (MTTB)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0     2e-05      0.12      41     112 ..     234     309 ..     213     321 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 2e-05
        MTTB  41 aieeaalriLeeiGiefl..dpealellkaaGakv..egervrfdrglvreliakapreftlharnPerdveiggk 112
                 ++ ++   iLe+i  +f      +lel+k+ G  +   +  +r dr++v e+i++ p+ ++  ++n ++d+ei   
  EFC37288.1 234 EMIREKTIILEDIPERFKteRHLVLELVKNCGIALrvLSSDMRNDREIVLEAIKNLPSAYQFASENLKNDIEIIKT 309
                 44556678999999888843445789******866448899******************************99655 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.51   3.1e+03     117     137 ..      25      45 ..      13      68 .. 0.74
   2 ?   -1.7   0.0       0.4   2.4e+03     131     162 ..     150     184 ..     103     188 .. 0.66
   3 ?    5.3   0.1    0.0027        16     132     157 ..     237     262 ..     215     266 .. 0.76
   4 ?    3.9   0.1    0.0076        45     121     164 ..     267     315 ..     258     331 .. 0.73

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.51
       Rad17 117 akylklqklGddlrtdkklil 137
                  +y  +++  +++r ++k+ l
  EFC37288.1  25 ENYFHMSRFSKEIRDNRKFKL 45 
                 478899999999999988754 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.4
       Rad17 131 tdkklilvedlPnkfyrds...dalrevirkylrs 162
                  ++ li + d P+  y  s   ++ ++ i+k+++s
  EFC37288.1 150 CELALIAIKDDPSAIYFISdelKRDKDFILKAIKS 184
                 35567777777765443330135555677777666 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.0027
       Rad17 132 dkklilvedlPnkfyrdsdalrevir 157
                   k i++ed+P++f+++ + + e+++
  EFC37288.1 237 REKTIILEDIPERFKTERHLVLELVK 262
                 4678999*********9998888776 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.0076
       Rad17 121 klqklGddlrtdkklil..vedlPnkfyrdsdalre...virkylrsse 164
                  l+ l  d+r d++++l  + +lP+ ++  s++l++   +i+++l+ s 
  EFC37288.1 267 ALRVLSSDMRNDREIVLeaIKNLPSAYQFASENLKNdieIIKTALQLSS 315
                 56778899*******998899***9999999999862226666666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (478 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       518  (0.0288917); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2690.84
//
Query:       EFC37289.1  [L=367]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (367 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 2089.49
//
Query:       EFC37290.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        5.6    7.8  11.3       0.11   13.3   4.1    1.8  2  DTHCT     DTHCT (NUC029) region


Domain annotation for each model (and alignments):
>> DTHCT  DTHCT (NUC029) region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   4.1   5.9e-06      0.11      24      67 ..     138     181 ..     133     196 .. 0.79
   2 ?   -4.1   0.7         1   1.8e+04      58      66 ..     275     283 ..     271     288 .. 0.50

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.9e-06
       DTHCT  24 kkkaaaaKgrkarKRktssssedddsdpgkktskatakKkkKka 67 
                 +  +++ K+ k  KRk+ +s ++dd d ++  s +++kK k ++
  EFC37290.1 138 AHHPPTRKTSKTLKRKAIDSGSEDDDDHSSVSSSTPKKKTKQQS 181
                 5667888866799****999999998888888877777776643 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 1
       DTHCT  58 atakKkkKk 66 
                 +  kK++K+
  EFC37290.1 275 QLPKKPSKP 283
                 444455554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       874  (0.0487478); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 2054.32
//
Query:       EFC37291.1  [L=459]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.5e-14   54.0   1.3    3.7e-14   52.7   1.1    1.7  1  Pkinase      Protein kinase domain
    4.4e-07   29.5   0.2    1.2e-06   28.0   0.1    1.6  2  Pkinase_Tyr  Protein tyrosine kinase
  ------ inclusion threshold ------
      0.031   14.6   0.0          2    8.8   0.0    2.5  2  HEPN_Swt1    Swt1-like HEPN


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.7   1.1   6.2e-18   3.7e-14      93     230 ..     263     412 ..     246     445 .. 0.76

  Alignments for each domain:
  == domain 1  score: 52.7 bits;  conditional E-value: 6.2e-18
                 SS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS...........BCTTTSCGGGS-HHHH.TTSCB.SHHH CS
     Pkinase  93 gslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...........ltsfvgtseYlAPEvl.keney.skkv 178
                 +s++ e+a k++ q+l  +  +H  + iH D+K +Ni i  ++  K++DF lak+++   +           + s  gt++ ++PE   ++++y ++ +
  EFC37291.1 263 VSVDFEKAVKMIVQLLVEMGKIHMLKYIHNDVKRSNIVIY-NDFTKLIDFELAKKFDFYDRenqicelfgdkVYSKAGTPNMMPPEKEkTGSGYiTPLT 360
                 567778899999****************************.999**********9876555668********9*************997567777**** PP

                 HHHHHHHHHHHHHHSS-STTTSSHHH.HHHHHHHTHHHHHHHCT.SHH...HHH CS
     Pkinase 179 DvWslGvilyelltgkppfsgekgke.kvekeldqlekilkilg.etkeklpea 230
                 D++ lG+++ e+l  +   s  ++++ +v +++++  ++ ++l+ ++k+ ++++
  EFC37291.1 361 DIYCLGIVISEILDWNLTVSTFSENQkRVITKIRE--MSSNMLHkDSKQRWDTD 412
                 *************9988877444333033444444..33333332444444443 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.1     2e-10   1.2e-06      95     220 ..     232     395 ..     174     410 .. 0.74
   2 ?   -0.6   0.1      0.11   6.4e+02      24      84 ..     384     444 ..     375     454 .. 0.68

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 2e-10
                  T............................CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEET..TTSSEE... CS
  Pkinase_Tyr  95 k............................ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi..ekddey... 159
                                               ++ ++++++ +++++q+   m  ++  k++H d+   N+++  n++ k+ Df La++   ++++++   
   EFC37291.1 232 LmsdrsvtfkipntasafyvemsfegkclTDVSVDFEKAVKMIVQLLVEMGKIHMLKYIHNDVKRSNIVIY-NDFTKLIDFELAKKFdfYDRENQice 328
                  2555566666666666666666666666667789999*********************************9.899**********9865666665555 PP

                  ...EETTSSTSGGGGS-HHHHHHSE..EEHHHHHHHHHHHHHHHHTTSSGTTTTS.HHHHHHHHHHT CS
  Pkinase_Tyr 160 ...vkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwEiftlgespypgl.kneevleklke 220
                      k  ++    + m+pE  k+++  +t  +D+++ G+++ Ei+    +  +   ++++v++k++e
   EFC37291.1 329 lfgDKVYSKAGTPNMMPPEKEKTGSgyITPLTDIYCLGIVISEILDWNLTVSTFSeNQKRVITKIRE 395
                  5544445566778899**999988777999**************98544333322245556666654 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.11
                  TTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--T CS
  Pkinase_Tyr  24 kekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvk 84 
                  +++k+v   ++ +++++ ++++++  +  ++++ l+ +ni++   +  ++e++   te+v+
   EFC37291.1 384 ENQKRVITKIREMSSNMLHKDSKQRWDTDRCLEYLQSENIISKNDILHEKENHGRTTEFVD 444
                  4455555556666777777777888888888888888888888888887777777777765 PP

>> HEPN_Swt1  Swt1-like HEPN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.019   1.2e+02      47      91 ..     101     143 ..      66     164 .. 0.85
   2 ?    8.8   0.0   0.00033         2      39     106 ..     349     416 ..     319     420 .. 0.79

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.019
   HEPN_Swt1  47 eiskldvqdllrvitenWkevFkkklsraerslaseLrevRNkwa 91 
                 +i ++dv++  +vi+   ke F++ ls+ +++ ase + +RN ++
  EFC37291.1 101 RITPSDVSNHNDVISPLAKE-FESLLSKVAEENASE-TSIRNLLS 143
                 5788999***********9*.***************.89999765 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00033
   HEPN_Swt1  39 eekkesekeiskldvqdllrvite..nWkevFkkklsraerslaseLrevRNkwaHqesfstddayrald 106
                 e++  s++ +  +d++ l  vi+e   W+    +++s++++++++++re+  ++ H++s +  d++r l+
  EFC37291.1 349 EKT-GSGYITPLTDIYCLGIVISEilDWNL-TVSTFSENQKRVITKIREMSSNMLHKDSKQRWDTDRCLE 416
                 333.36777777899999999999999*88.8889**********************9999999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       851  (0.047465); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 2665.12
//
Query:       EFC37292.1  [L=110]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.024   15.5   4.0      0.047   14.5   4.0    1.5  1  ANAPC_CDC26  Anaphase-promoting complex APC subunit CDC26
        0.1   11.5   4.5       0.12   11.3   4.5    1.0  1  NARP1        NMDA receptor-regulated protein 1
       0.19   11.3   3.1       0.21   11.1   3.1    1.0  1  NABP         Nucleic acid binding protein NABP
       0.34   10.9   6.3        0.4   10.7   6.3    1.1  1  INO80_Ies4   INO80 complex subunit Ies4
        1.1    9.1   5.7        1.6    8.6   5.7    1.2  1  DUF1068      Protein of unknown function (DUF1068)


Domain annotation for each model (and alignments):
>> ANAPC_CDC26  Anaphase-promoting complex APC subunit CDC26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   4.0   1.3e-05     0.047      14      62 ..      48      89 ..      33      98 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.3e-05
  ANAPC_CDC26 14 eDiaeyederqrqkeqaaqqqrsqasastsqasdtdaddftsedadpnd 62
                 eD+  y+  +q++++++++ ++s+++++t+++ ++++         + +
   EFC37292.1 48 EDLKPYIKVKQEEQKKKKALNSSSSATTTTTTLEQQNTT-------TSN 89
                 677777777999999999999999888888777765322.......222 PP

>> NARP1  NMDA receptor-regulated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   4.5   3.4e-05      0.12     374     454 ..      12      95 ..       6     104 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3.4e-05
                 HHHHHHHHHHHHHHH-TTGGG---H.HHHHT-S-HHHHHHHHHHHHHHHHHHHHHHHHHHHHH--.........---------- CS
       NARP1 374 kaakgaievYlkledkpkakeeeke.eaksaelseaerkklrkkakkaekkaekeeaekaekekekk..aaekkakkedeeakk 454
                 k ak  ++   +++d+++++ee +  e++ +e  ++e  k   k k++e+k++k+ ++++++ ++++  ++++++++++e++k 
  EFC37292.1  12 KDAKPVVKKVSEMNDEELLNEELELtEEELKEFGDDEDLKPYIKVKQEEQKKKKALNSSSSATTTTTtlEQQNTTTSNEEKPKV 95 
                 6678888889999****8877755427777788888888888899999887777766666655554423444444555554444 PP

>> NABP  Nucleic acid binding protein NABP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   3.1   5.7e-05      0.21      28     123 ..       4      93 ..       1      99 [. 0.83

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.7e-05
        NABP  28 fngvssgiaesadlvaaLSglnLsknrlldeeshvrsqleqelddqedflfnvqggqnqlkqqkllkkseseslkisasyadlakkngslsdlnas 123
                  ++ +s  ++ + +v  +S++n  +++ll+ee ++ ++  +e+ d ed+   ++ +q++ k++k l++s+s++ ++      l+++n ++s+ +++
  EFC37292.1   4 SSTLTSASKDAKPVVKKVSEMN--DEELLNEELELTEEELKEFGDDEDLKPYIKVKQEEQKKKKALNSSSSATTTTT----TLEQQNTTTSNEEKP 93 
                 5677899999999******998..77799********************9999999999999999999998886555....566666666666555 PP

>> INO80_Ies4  INO80 complex subunit Ies4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   6.3   0.00011       0.4      18      88 ..      22     101 ..       2     106 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00011
  INO80_Ies4  18 sekakkk.livtlkvspekLrailed.........kekekkeekespasssaapaakaeskadnasdsnsatPaegtPaps 88 
                 se ++++ l   l+++ e+L+++ +d         k++e+k++k+  +ss +a++++++ +++n++ sn + P+   P+ps
  EFC37292.1  22 SEMNDEElLNEELELTEEELKEFGDDedlkpyikvKQEEQKKKKALNSSS-SATTTTTTLEQQNTTTSNEEKPKVLPPNPS 101
                 2222223234579************6678888875333333333333333.333334445678899999999987777765 PP

>> DUF1068  Protein of unknown function (DUF1068)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   5.7   0.00044       1.6      69     151 ..       9      92 ..       2      96 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00044
     DUF1068  69 dCakh.dpevseemeknfvdllseelklreaeaeekqkradvalleakklasqYqkeAdKCnsgmetcEeaREkaeaalaeekk 151
                   +k+ +p v++  e n  +ll+eel+l e+e +e     d +     k   q +k A   +s+  t+  + E+ +++ ++e+k
  EFC37292.1   9 SASKDaKPVVKKVSEMNDEELLNEELELTEEELKEFGDDEDLKPYIKVKQEEQKKKKALNSSSSATTTTTTLEQQNTTTSNEEK 92 
                 4555426888999999*******************9999998877777778888888888888888888888887777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (110 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2465  (0.137487); expected 358.6 (0.02)
Passed bias filter:                      797  (0.0444531); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.46u 0.31s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 720.85
//
Query:       EFC37293.1  [L=343]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.6e-72  242.1   0.0    1.1e-71  242.0   0.0    1.0  1  NMO            Nitronate monooxygenase
    1.2e-12   47.5   0.2    2.3e-10   40.0   0.2    2.1  1  IMPDH          IMP dehydrogenase / GMP reductase domain
    5.1e-08   32.4   2.0    6.7e-08   32.0   0.6    1.8  3  DUF561         Protein of unknown function (DUF561)
    2.2e-05   23.9   0.1    2.9e-05   23.4   0.1    1.2  1  DHO_dh         Dihydroorotate dehydrogenase
    9.8e-05   21.9   0.3    0.00037   20.0   0.3    1.8  1  His_biosynth   Histidine biosynthesis protein
    0.00025   20.2   1.1    0.00042   19.5   0.2    1.7  2  FMN_dh         FMN-dependent dehydrogenase
    0.00035   20.0   0.1    0.00058   19.2   0.1    1.3  1  ThiG           Thiazole biosynthesis protein ThiG
    0.00057   19.1   0.1     0.0011   18.2   0.1    1.4  1  NanE           Putative N-acetylmannosamine-6-phosphate epime
     0.0063   15.9   0.8       0.02   14.2   0.8    1.8  1  TMP-TENI       Thiamine monophosphate synthase
     0.0078   15.5   0.2        1.4    8.1   0.2    2.1  2  PEP_hydrolase  Phosphoenolpyruvate hydrolase-like
  ------ inclusion threshold ------
      0.015   14.7   0.1      0.029   13.8   0.1    1.4  1  G3P_antiterm   Glycerol-3-phosphate responsive antiterminator
      0.031   14.1   0.3        1.9    8.4   0.0    3.4  4  IF2_N          Translation initiation factor IF-2, N-terminal
       0.12   11.4   0.1       0.48    9.5   0.0    1.9  2  Dus            Dihydrouridine synthase (Dus)
        5.2    6.7  12.0       0.71    9.5   3.1    3.3  3  VASP_tetra     VASP tetramerisation domain


Domain annotation for each model (and alignments):
>> NMO  Nitronate monooxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  242.0   0.0   8.4e-75   1.1e-71       4     330 ..       4     340 ..       1     341 [. 0.93

  Alignments for each domain:
  == domain 1  score: 242.0 bits;  conditional E-value: 8.4e-75
         NMO   4 ltellkikppvvqpgmggiskarLaaavsnaGgLGvlasgyltaDrlakeirkvkaltdkPfgvnlflpkkdaadra.ekykkeleeaalelnieegvr 101
                 ++ llk+k+p++q++m g  +  La  vs+ G+LG+l  ++l   +++ ei+k+k +td+ f++n f  ++  + +  +++++++e+  +e n+e  + 
  EFC37293.1   4 IKRLLKVKYPIIQAPMAGAQNSTLAIQVSKFGALGSLPCATLDIEEMRREIKKIKLATDHSFNLNFFCHENPNNTKNeNQWRQIIEKYYQEFNVEFKIS 102
                 67899**************************************************************9988777776699*******999999988888 PP

         NMO 102 .......fyrkvevvlde.kvevvsfgfglpteevvarlkeagvvliptissvkearkvearGaDalivqGpeaGGhqG...tpevgd.kglfaLvpqv 188
                        f + +  vl+e k+ vvsf+fglp++e v++lk++++ ++ ++++v+ea  +e+ G D++i+qG eaGGh+G   + ++ +  glf+L+pq+
  EFC37293.1 103 ssisrlpFNENIIPVLNEfKPIVVSFHFGLPSKEIVKELKRMNIRIMSSATTVEEALYLEENGVDIIIAQGIEAGGHRGmflSNDISTqMGLFSLLPQI 201
                 8899***999999888888************************************************************76633444469********* PP

         NMO 189 ldavdiPviAaGGiidrrgvaaaLalGAsgvqigtrfLltkesdakdahkkklleaklddteltsavsGrpaRalatelleeleeakiatlalpeahel 287
                 ++ v++Pv+AaGGi+d++ v aa+ lGAsgvq gt fL ++es++k   k+ l++     t +t  + GrpaR ++++ ++e+    + + ++p+  + 
  EFC37293.1 202 VKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFLTCQESTVKY--KQLLTDV-SLPTAVTNIFTGRPARSIVNRAMKEIGTISEYAPPFPKSTNY 297
                 *******************************************9984..6666655.55799***********************999999******** PP

         NMO 288 akkiraalveagnteegllwagqgidrldkiisvkeLiesLve 330
                   ++r+ l +  n +   lw+gq+    +   + +e++++L++
  EFC37293.1 298 FTPLRNHLERELNFDFSQLWSGQNRTNCKLDSTSHEILQDLIQ 340
                 *****************************************97 PP

>> IMPDH  IMP dehydrogenase / GMP reductase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.0   0.2   1.8e-13   2.3e-10      29     249 ..       6     248 ..       2     254 .. 0.83

  Alignments for each domain:
  == domain 1  score: 40.0 bits;  conditional E-value: 1.8e-13
                 TTEEESSSEEE-SSTTT-SHHHHHHHHHTTSEEEE-SS.S-HHHHHHHHHHHHTS............................TTSXBXTTSXB-EEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxx............................xxxxxxxxxxxxxxxx RF
       IMPDH  29 kkiklniPlvsaamdtvtesemAialareGgigvihkn.lsieeqaeevkkvkrs............................pnaakdekgrllvgaa 98 
                 + +k++ P++ a+m    +s++Ai++++ G++g +    l+iee  +e+kk+k +                            ++  ++ + ++ ++++
  EFC37293.1   6 RLLKVKYPIIQAPMAGAQNSTLAIQVSKFGALGSLPCAtLDIEEMRREIKKIKLAtdhsfnlnffchenpnntknenqwrqiiEKYYQEFNVEFKISSS 104
                 66899*****************************986438*************999*******************999999988888888999999999 PP

                 E-SSTTHHHHHHHHHHTT-SEEEEE-STSSSHHHHHHHHHHHHHTTTSEEEEEEE-SHHHHHHHHHTT-SEE.EE-SS-STTBHHHHHCSB---HHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx RF
       IMPDH  99 vgvkedalervkalveagvdvlvvdsahghsekvleavkeikkkveeveviaGnvataegakaLieagadav.kvGiGpGsiCttrvvagvGvpqltAv 196
                 ++    +++ +  l e     +vv    g  +   e vke+k+    ++ i  + +t e a  L e+g+d++   Gi +G        +     q+   
  EFC37293.1 105 ISRLPFNENIIPVLNEF--KPIVVSFHFGLPS--KEIVKELKRMN--IR-IMSSATTVEEALYLEENGVDIIiAQGIEAGGHRGMFL-SNDISTQMGLF 195
                 99998666667766554..5677777777654..45678887655..54.56688999************86267999998543333.33334577777 PP

                 HHHHHHHCTCT-EEEEES---SHHHHHHHHHTT-SEEEESCCCTTBTTSSSEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       IMPDH 197 aevaeaakkagvpviaDGGikysgdivkAlaaGadavmlGsllagteEspgev 249
                 +   +++kk +vpv+a GGi   + ++ A+ +Ga+ v +G ++  ++Es  ++
  EFC37293.1 196 SLLPQIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFLTCQESTVKY 248
                 7778899*****************************************98765 PP

>> DUF561  Protein of unknown function (DUF561)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       3.3   4.2e+03     186     236 ..      11      60 ..       9      67 .. 0.54
   2 ?   -2.2   0.0       1.5   1.9e+03     143     185 ..      64     105 ..      44     111 .. 0.68
   3 !   32.0   0.6   5.2e-11   6.7e-08     131     220 ..     151     241 ..     144     263 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.3
      DUF561 186 slPvicasGlsdvtvplalslgasGiGigsavsklndeeemvallseikka 236
                 + P+i a       + la++++  G  +gs      d+eem   +++ik a
  EFC37293.1  11 KYPIIQAPMAGAQNSTLAIQVSKFG-ALGSLPCATLDIEEMRREIKKIKLA 60 
                 5566666544444455555544444.2455555555666666666666655 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.5
      DUF561 143 slgvdliqteGkitsiskakkvndliekslstlastyeiskkv 185
                 s ++++   e   ++  ++++ +++iek  + +   ++is+++
  EFC37293.1  64 SFNLNFFCHEN-PNNTKNENQWRQIIEKYYQEFNVEFKISSSI 105
                 55566666665.4455556777888888888888888888877 PP

  == domain 3  score: 32.0 bits;  conditional E-value: 5.2e-11
      DUF561 131 leeqvkLakkLeslgvdliqteGkitsiskakkvndliekslstlastyeiskkvslPvicasGlsd.vtvplalslgasGiGigsavskl 220
                     v+ a  Le+ gvd+i + G  +   +   +++ i + +  ++   +i+kkv++Pv++a G+ d  tv  a++lgasG+  g      
  EFC37293.1 151 SATTVEEALYLEENGVDIIIAQGIEAGGHRGMFLSNDISTQMGLFSLLPQIVKKVKVPVVAAGGIVDaQTVTAAFQLGASGVQCGTVFLTC 241
                 5567788899*************66666678889999***************************9872699***********999865444 PP

>> DHO_dh  Dihydroorotate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.1   2.3e-08   2.9e-05     111     276 ..      47     238 ..      19     254 .. 0.68

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 2.3e-08
                 HHHHHHHHHHHG.GGESEEEEES-SCTCCTSCCCGCHHHHHHHHHHHHHHHH.................SSEEEEEE-SSSSHHH....HHHHHHHHHH CS
      DHO_dh 111 vddyvevvrkig.pfadilelNvSsPntpglrdlqekeelkaillkvvkevs.................kvpvlvKlaPdltdee....kkdiadvlle 187
                 +++ +  ++ki+    + + lN  + + p     +++++ ++i+ k  +e++                  +pvl    P +  ++     k+i+++l++
  EFC37293.1  47 IEEMRREIKKIKlATDHSFNLNFFCHENPNNT--KNENQWRQIIEKYYQEFNvefkisssisrlpfnenIIPVLNEFKPIVVSFHfglpSKEIVKELKR 143
                 56666666666655555666666666665333..334445555555566655666677777777777766677777777655443222279999***** PP

                 HTECEEEE...BSEE-.-CTTCCGCCCCTT..SSEEEEEGGG.HHHHHHH.....HHHHHHHTTT.S-EEEESS--SHHHHHHHHHHTECEEEESHHH CS
      DHO_dh 188 lkldgiivtNttvqrl.aidlkseknvkan..ktGGlsGkal.kdialkv.....irelykrlkkeipiIgvGGiesgeDalekieaGAslvqvytal 276
                 +++  +  + ttv+    ++ +  + + a+  ++GG  G  l  di++++     + ++ k++k  +p+++ GGi  ++ +   ++ GAs vq +t +
  EFC37293.1 144 MNIRIMS-SATTVEEAlYLEENGVDIIIAQgiEAGGHRGMFLsNDISTQMglfslLPQIVKKVK--VPVVAAGGIVDAQTVTAAFQLGASGVQCGTVF 238
                 ***9998.56666555044444445555557789******994589998653222455555555..9*****************************87 PP

>> His_biosynth  Histidine biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.3   2.9e-07   0.00037     181     225 ..     196     240 ..     134     244 .. 0.74

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 2.9e-07
                   HHHHHHHHHHSSEEEEESS--SHHHHHHHHHTTCSEEEESHHHHT CS
  His_biosynth 181 eltkelaeavkipviasGGvgsledlkelksegvdavivgsalye 225
                   +l+ ++ ++vk+pv+a+GG+ + + + ++++ g+++v +g+++++
    EFC37293.1 196 SLLPQIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFLT 240
                   556677777777777777777777777777777777777777765 PP

>> FMN_dh  FMN-dependent dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.1   1.4e+03      56      70 ..       9      23 ..       9      31 .. 0.81
   2 !   19.5   0.2   3.3e-07   0.00042     226     304 ..     154     239 ..     144     244 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.1
                EESSSEEE--BSTGG CS
      FMN_dh 56 klslPvliaPvglak 70
                k+++P++ aP++ a+
  EFC37293.1  9 KVKYPIIQAPMAGAQ 23
                589********7654 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 3.3e-07
                 SHHHHHHHHHTTESEEEE-..-GGG.......TSSTT---HHHCHHHHHHHH..SS-EEEESS--SHHHHHHHHHTT-SEEEESHHHH CS
      FMN_dh 226 taedakraveaGvdgivvS..NHGG.......RqldgapatidvLpeiveavggrievlvDgGirrGsDvlkAlalGAdavllGRpfl 304
                 t+e+a  + e Gvd+i+      GG         + + +  ++ Lp+iv++v+  ++v++ gGi   + v  A  lGA++v  G  fl
  EFC37293.1 154 TVEEALYLEENGVDIIIAQgiEAGGhrgmflsNDISTQMGLFSLLPQIVKKVK--VPVVAAGGIVDAQTVTAAFQLGASGVQCGTVFL 239
                 566666666777766654322234433344444455555567889*******8..****************************98887 PP

>> ThiG  Thiazole biosynthesis protein ThiG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.1   4.6e-07   0.00058     133     206 ..     167     237 ..     156     252 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 4.6e-07
                 -HHHHHHHHHTT-SEBEEBSSSTTS----S-HHHHHHHHHH-SS-BEEES---SHHHHHHHHHTT-SEEEESHH CS
        ThiG 133 DlvlarrleevGcaavmPlaapiGsglGllnkealkiiieeakvPvivDAGigspsdaaqamelGadavllnta 206
                 D+++a+ + e+G +  m l+  i + +Gl +   l  i++++kvPv+   Gi  ++ +++a++lGa++v   t 
  EFC37293.1 167 DIIIAQGI-EAGGHRGMFLSNDISTQMGLFS--LLPQIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCGTV 237
                 66666665.6777888999*********985..799********************************988776 PP

>> NanE  Putative N-acetylmannosamine-6-phosphate epimerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.1   8.3e-07    0.0011      82     187 ..     135     249 ..     129     254 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 8.3e-07
                 HHHHHHHHHH--EEEEE-SSHHHHHHHHHTT-SEE...E-TTTTSSTTS-......SS--HHHHHHHH.HTT--EEEES---SHHHHHHHHTT--SEEE CS
        NanE  82 eelikkikekyqllmaDistleeglvakklGvdiv...GttlsGytkeeek.....aepDfalvkals.eaglkviaeGrintPekakkaieiGvdavv 171
                 +e++k++k++   +m+   t+ee+l+ ++ Gvdi+   G    G+ +         +   f+l+ +++ + ++ v+a G i   +    a+++G+  v 
  EFC37293.1 135 KEIVKELKRMNIRIMSSATTVEEALYLEENGVDIIiaqGIEAGGHRGMFLSndistQMGLFSLLPQIVkKVKVPVVAAGGIVDAQTVTAAFQLGASGVQ 233
                 789******************************98555444555543322211223666788998776156899************************* PP

                 E-HHHH-HHHHHHHHH CS
        NanE 172 vGsaitrleeiakkfv 187
                  G+     +e + k+ 
  EFC37293.1 234 CGTVFLTCQESTVKYK 249
                 **98776666666665 PP

>> TMP-TENI  Thiamine monophosphate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.8   1.6e-05      0.02      93     175 ..     142     232 ..     132     236 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.6e-05
    TMP-TENI  93 lgpdliiGlSvhsleeaeeaealgadYigvGpifpTdtK.....kda.eplgl.eglkelaealeiPvvaiGGi.tlenvaevleagadgv 175
                    +  i  S+ + eea+ +e++g+d i +  i +   +     +d  + +gl ++l ++++++++Pvva GGi ++++v ++++ ga+gv
  EFC37293.1 142 KRMNIRIMSSATTVEEALYLEENGVDIIIAQGIEAGGHRgmflsNDIsTQMGLfSLLPQIVKKVKVPVVAAGGIvDAQTVTAAFQLGASGV 232
                 5556667777888888888888888877765554444331111123335666625679***************845667778889999998 PP

>> PEP_hydrolase  Phosphoenolpyruvate hydrolase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0     0.007       8.9     191     266 ..      45     123 ..      16     124 .. 0.63
   2 !    8.1   0.2    0.0011       1.4     141     223 ..     137     216 ..     134     235 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.007
  PEP_hydrolase 191 lsleeavelvqeiadaakevnpdvivlvhGGpiaepe..daeyvlertkg..vkGfigassleRlpvekaikettkeFks 266
                    l++ee+ +++++i   a++ + +   ++h  p ++++  + ++++e+  +     f  +ss+ Rlp++++i  + +eFk 
     EFC37293.1  45 LDIEEMRREIKKIK-LATDHSFNLNFFCHENPNNTKNenQWRQIIEKYYQefNVEFKISSSISRLPFNENIIPVLNEFKP 123
                    45566667777664.44455566777777777655541145566655332113468999*******************96 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0011
  PEP_hydrolase 141 likkAheldllttayvfneeearamaeaGadvivahlGlttggsigaktalsleeavelvqeiadaakevnpdvivlvhGGpi 223
                    ++k+ +++++  ++ +++ eea  + e G+d+i+a+ G+ +gg+ g+  ++++++ + l + + + +k+v+    v++ GG +
     EFC37293.1 137 IVKELKRMNIRIMSSATTVEEALYLEENGVDIIIAQ-GIEAGGHRGMFLSNDISTQMGLFSLLPQIVKKVKVP--VVAAGGIV 216
                    677778888888999999**************9986.*********999999999999998888888888644..34455544 PP

>> G3P_antiterm  Glycerol-3-phosphate responsive antiterminator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   2.3e-05     0.029     130     168 ..     197     235 ..     192     239 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.3e-05
                   HHCTSTTS...EEEEESS--SHHHHHHHCTT.SSEEEE- CS
  G3P_antiterm 130 vikeikkelkipiiaGGLietkedveealkaGaiavsts 168
                   ++ +i k++k+p++a+G i + ++v++a++ Ga++v ++
    EFC37293.1 197 LLPQIVKKVKVPVVAAGGIVDAQTVTAAFQLGASGVQCG 235
                   6778999****************************9875 PP

>> IF2_N  Translation initiation factor IF-2, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.28   3.6e+02      19      40 ..      86     106 ..      85     107 .. 0.91
   2 ?    8.4   0.0    0.0015       1.9      14      38 ..     131     154 ..     129     158 .. 0.78
   3 ?   -2.3   0.0       3.2     4e+03      30      47 ..     207     224 ..     200     226 .. 0.75
   4 ?   -1.1   0.0       1.3   1.7e+03      14      30 ..     328     342 ..     326     343 .] 0.77

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.28
       IF2_N  19 evikkLfkelGievkshsssLD 40 
                 ++i+k  +e+ +e  ++sss++
  EFC37293.1  86 QIIEKYYQEFNVE-FKISSSIS 106
                 69***********.*****997 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0015
       IF2_N  14 gvkskevikkLfkelGievkshsss 38 
                 g++ske++k+L k + i   s   +
  EFC37293.1 131 GLPSKEIVKEL-KRMNIRIMSSATT 154
                 89*********.8899986665555 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 3.2
       IF2_N  30 ievkshsssLDeetaeli 47 
                 ++v+ +  ++D++t++++
  EFC37293.1 207 VPVVAAGGIVDAQTVTAA 224
                 677778888999999886 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 1.3
       IF2_N  14 gvkskevikkLfkelGi 30 
                   +s+e+++ L   +Gi
  EFC37293.1 328 DSTSHEILQDL-I-QGI 342
                 56899*****9.6.677 PP

>> Dus  Dihydrouridine synthase (Dus)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.93   1.2e+03       2      23 ..      16      37 ..      15      76 .. 0.78
   2 ?    9.5   0.0   0.00037      0.48     177     213 ..     200     235 ..     186     259 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.93
                E---TTTS-HHHHHHHHHTT-S CS
         Dus  2 laPmagvtdlpfRelvrefgat 23
                 aPmag  ++++   v +fga 
  EFC37293.1 16 QAPMAGAQNSTLAIQVSKFGAL 37
                6999999999999999999875 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00037
                 HHHHH-SS-EEEESS--SHHHHHHHHHHH--SEEEES CS
         Dus 177 evkqavsipviaNGdIkdaedaqaileetGadgvmig 213
                 ++ ++v++pv+a G+I da+ + a+ +  Ga gv +g
  EFC37293.1 200 QIVKKVKVPVVAAGGIVDAQTVTAAFQL-GASGVQCG 235
                 78999********************999.**999887 PP

>> VASP_tetra  VASP tetramerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.42   5.4e+02      19      29 ..       7      17 ..       5      20 .. 0.87
   2 ?    9.5   3.1   0.00055      0.71      12      23 ..      47      58 ..      47      59 .. 0.94
   3 ?   -0.3   0.7      0.63     8e+02      13      21 ..     135     143 ..     135     145 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.42
  VASP_tetra 19 LqKvKeEIIeA 29
                L KvK  II A
  EFC37293.1  7 LLKVKYPIIQA 17
                67*******98 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00055
  VASP_tetra 12 LeEvrkELqKvK 23
                +eE+r+E++K+K
  EFC37293.1 47 IEEMRREIKKIK 58
                69*********9 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.63
  VASP_tetra  13 eEvrkELqK 21 
                 +E++kEL+ 
  EFC37293.1 135 KEIVKELKR 143
                 578888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       665  (0.0370907); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 1928.25
//
Query:       EFC37294.1  [L=347]
Description: hypothetical protein NAEGRDRAFT_81996 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-35  120.1   0.6    1.2e-34  119.2   0.6    1.5  1  Gp_dh_C   Glyceraldehyde 3-phosphate dehydrogenase, C-termina
    3.6e-17   62.8   0.5    8.5e-17   61.6   0.5    1.6  1  PH        PH domain
    2.3e-08   34.4   0.7      5e-08   33.3   0.7    1.5  1  PH_9      Pleckstrin homology domain
    2.1e-05   24.9   0.7    2.1e-05   24.9   0.7    2.9  3  PH_11     Pleckstrin homology domain
     0.0032   17.8   0.3      0.042   14.1   0.0    2.7  3  PH_6      Pleckstrin homology domain
  ------ inclusion threshold ------
      0.055   13.9   0.3        0.2   12.1   0.3    2.0  1  Mvb12     ESCRT-I subunit Mvb12
       0.13   12.5   5.7       0.11   12.8   2.4    2.6  2  PH_8      Pleckstrin homology domain


Domain annotation for each model (and alignments):
>> Gp_dh_C  Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  119.2   0.6   4.6e-38   1.2e-34      17     158 .]     183     326 ..     170     326 .. 0.87

  Alignments for each domain:
  == domain 1  score: 119.2 bits;  conditional E-value: 4.6e-38
                 EEEEEEEECTTTSBSSSS--..SSTTTTSBTTCSSEEEE-THHHHHHHHSGGGTTTEEEEEEEESSSSEEEEEEEEEESSTS-HHHHHHHHHHHHH.TT CS
     Gp_dh_C  17 glmttvhaytndQkllDgps.kkdlrraraaaeniiptstgaakavglVlpelkgkldglAvrVPtpnvsvvdlvvelekevtveevnaalkeaae.ga 113
                   +t+v a  nd  +    s   +  +  +  ++   ++ + +k  glV+p+l+gkl+g+A+rVPt++vsvvdl+++lek++t++++ +a+k+a+e ++
  EFC37294.1 183 LQVTIVEAKLNDEFINKENSkLDQDEKNDIIQQSHFQVNCKFHKQKGLVIPSLNGKLTGMAFRVPTVDVSVVDLTCRLEKPATKKQIDEAMKAASEsER 281
                 5667777777773333333323344555666688888899999999**************************************************999 PP

                 TTTTEEEEHSHHHGGGGTTGCSSEEEEGGGCEEETTTEEEEEEEE CS
     Gp_dh_C 114 lkgilsyteeelvssDlvgdphssifdaketivveenlvkvvawy 158
                 +kgil++t+ee+vssD+v+d++ss++d+k++i ++e++vkvvawy
  EFC37294.1 282 FKGILKFTDEEVVSSDFVHDSASSTYDSKASICLNEHFVKVVAWY 326
                 ********************************************9 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.6   0.5   3.3e-20   8.5e-17       2     100 ..      52     164 ..      51     168 .. 0.87

  Alignments for each domain:
  == domain 1  score: 61.6 bits;  conditional E-value: 3.3e-20
                 EEEEEEEEETSSSSC........SEEEEEEEEETTEEEEESST.........TCTTESSEEEEEESTT.EEEEEEECTTSSSSTSEEEEEESTSSSTEE CS
          PH   2 vkeGwLlkkgsgkkk........swkkrwfvLkdsellyyknd.........ksekdkepkgsislsn.cevvevvatedpkrkfcfelriverngsrt 82 
                 +k+G+L+kk  + +k        +wkkrwfvL++++++yyk+          + +++++p g+isl + +++++++ ++ +   f+f+++++      +
  EFC37294.1  52 YKQGYLSKKPLKSSKstfkykfkGWKKRWFVLQKTSIYYYKDAaiaaaaqleSQNSKYQPLGIISLAEdIKIEKDEIESVESGMFVFKIITP----YAQ 146
                 799**9977776666778899*********************************************75155555543669999999999888....799 PP

                 EEEEESSHHHHHHHHHHH CS
          PH  83 yllqasseeerkeWikai 100
                 +l++asse+er+eWi +i
  EFC37294.1 147 HLIAASSEQERREWIDSI 164
                 9**************999 PP

>> PH_9  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.7     2e-11     5e-08       1     114 [.      52     164 ..      52     167 .. 0.83

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 2e-11
        PH_9   1 ykegivqrkllleskgkktplkkrgWkevyavlkklvLylykdeeesesaetedlkslknakllgkirlhhaLaekasdYkk...kshvFrLqtadgae 96 
                 yk+g++ +k l  sk +++ +k +gWk+ + vl+k+ +y ykd   +  a++e+ +s  + ++lg+i+l+  +  +  + ++     +vF++ t   a+
  EFC37294.1  52 YKQGYLSKKPLKSSK-STFKYKFKGWKKRWFVLQKTSIYYYKDAAIAAAAQLESQNS--KYQPLGIISLAEDIKIEKDEIESvesGMFVFKIITP-YAQ 146
                 788998888765555.55559********************************8554..7779*********99997776655115577777665.799 PP

        PH_9  97 ylfqtsdakevqeWvdti 114
                  l+++s+++e +eW+d i
  EFC37294.1 147 HLIAASSEQERREWIDSI 164
                 9***************87 PP

>> PH_11  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       4.6   1.2e+04      66      82 ..      15      31 ..       6      45 .. 0.55
   2 !   24.9   0.7   8.3e-09   2.1e-05       3     102 ..      55     164 ..      53     166 .. 0.61
   3 ?    3.0   0.2     0.051   1.3e+02      35      70 ..     175     211 ..     171     233 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 4.6
       PH_11 66 irssksddllleistet 82
                 +++++++ l + s++t
  EFC37294.1 15 NNNHNNNRSLEQYSQST 31
                33333344444444443 PP

  == domain 2  score: 24.9 bits;  conditional E-value: 8.3e-09
       PH_11   3 Gylkkkgsk...........aWkrrwfavlkdgvLeyYksekkkvvkhviklSngseaklkad.lisaalfkidsirssksddll..leistetkiffl 87 
                 Gyl kk  k           +Wk+rwf vl+++ + yYk+          +l  +++   +   ++ a+  ki++++ ++ ++ +  ++i t      +
  EFC37294.1  55 GYLSKKPLKsskstfkykfkGWKKRWF-VLQKTSIYYYKDAAIAA---AAQLESQNSKYQPLGiISLAEDIKIEKDEIESVESGMfvFKIITPYAQHLI 149
                 66666555555566777788*******.***********988887...333333333333333033344445555555444444400444444444458 PP

       PH_11  88 kgdsneeteeWveal 102
                 ++ s++e+ eW+ ++
  EFC37294.1 150 AASSEQERREWIDSI 164
                 9999999****9876 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.051
       PH_11  35 kvvkhviklSngs.eaklkadlisaalfkidsirssk 70 
                 k v++v kl   + eakl+ + i++++ k+d+++ + 
  EFC37294.1 175 KLVQYVTKLQVTIvEAKLNDEFINKENSKLDQDEKND 211
                 6689999998765379999999999999988877633 PP

>> PH_6  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       2.2   5.7e+03      74      87 ..      60      73 ..       6      86 .. 0.55
   2 !   14.1   0.0   1.6e-05     0.042      57     109 ..     105     164 ..     101     166 .. 0.76
   3 ?   -0.2   0.0      0.45   1.2e+03      21      58 ..     254     292 ..     243     311 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.2
        PH_6 74 evaadgeqkFhlta 87
                ++ ++ ++ F+ + 
  EFC37294.1 60 KPLKSSKSTFKYKF 73
                34444444454444 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 1.6e-05
        PH_6  57 kedkaspsgvinLadasevaad.......geqkFhltakGkkhtFkasstaeRdnWvaql 109
                 ++ k  p g+i+La+  ++++d       g   F++ +   +h   ass +eR +W+  +
  EFC37294.1 105 QNSKYQPLGIISLAEDIKIEKDeiesvesGMFVFKIITPYAQHLIAASSEQERREWIDSI 164
                 456779*******987766655222211166678889999*****************987 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.45
        PH_6  21 lssllksekeaesaed.aheviawAsetGkGLLffskke 58 
                 ++   + ek+a + +      +a  se  kG+L f+++e
  EFC37294.1 254 VDLTCRLEKPATKKQIdEAMKAASESERFKGILKFTDEE 292
                 444444455554433326666777788888888888654 PP

>> Mvb12  ESCRT-I subunit Mvb12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.3   7.9e-05       0.2      20      76 ..       5      61 ..       2      68 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.9e-05
                -------------HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHS--XXX CS
       Mvb12 20 sklevpelkleelqptkemlepwykecdelvealekhdksgeeFdkWYkekyLskkP 76
                ++l+ p+   ++ ++ +  le++ +    l ++  +  ks  + ++ Yk+ yLskkP
  EFC37294.1  5 KQLSSPNNMNNNNHNNNRSLEQYSQSTTGLLQSTLTLSKSATSNNQIYKQGYLSKKP 61
                677788888888999999**************************************9 PP

>> PH_8  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1         2   5.1e+03      27      54 ..      23      50 ..      19      54 .. 0.79
   2 ?   12.8   2.4   4.3e-05      0.11       9      71 ..      71     141 ..      64     168 .. 0.56

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2
        PH_8 27 tlsYyrddnssalrgkiplslaiisane 54
                +l+ y ++  + l+  ++ls+++ s n+
  EFC37294.1 23 SLEQYSQSTTGLLQSTLTLSKSATSNNQ 50
                5777888888899999999999888775 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 4.3e-05
        PH_8   9 kklqgyakRfFvLdlksstlsYyrddnss...alrgk....iplsla..iisaneekrei.iidsGaevWeLk 71 
                  k +g++kR+FvL  +++++ Yy+d+  +   +l  +     pl +   + +++ ek ei +++sG+ v++++
  EFC37294.1  71 YKFKGWKKRWFVL--QKTSIYYYKDAAIAaaaQLESQnskyQPLGIIslAEDIKIEKDEIeSVESGMFVFKII 141
                 4789*********..999*****99754433344433111123332211223444555553578888777543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       981  (0.0547158); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 1930.76
//
Query:       EFC37295.1  [L=226]
Description: hypothetical protein NAEGRDRAFT_75078 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        7.9    5.2   9.9        9.6    4.9   9.9    1.1  1  ALMT      Aluminium activated malate transporter


Domain annotation for each model (and alignments):
>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   9.9   0.00053       9.6     275     422 ..      21     169 ..      10     214 .. 0.68

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.00053
        ALMT 275 ealhgcilseiqapeelrkkfkeelqrvslesakvlrelaesvkkmkklsk.veellkevkvaaeeLqskldskskLlvnsekweaakkkekaeeveek 372
                 ++ h++il++++ +++ ++ +  + +++++  ++vl  l+++ +++  + k + ++  ++   ++ Lq++ +++++ +vn ++ +++ + ++ +e +  
  EFC37295.1  21 HSHHNNILNNTNNNNNNNNLITFQNNNNNILDGEVLDRLEKEYQTKIYNIKiALDTPPDLLANIKFLQHQQQQQQNHFVNNNNTTINGNFQQDSEDDVM 119
                 5679999999999999999999999999999**********9998877777455677789999******************998888777777776666 PP

        ALMT 373 keeekeseskkeea.........................eaveeaeseseksllkeskrslklskkesapaeesl 422
                  e +++++ ++  +                         +                         +++ +++++ 
  EFC37295.1 120 LEDQDDDDDDEYDSssdddfinqfnpihyhdmntsiyipN-------------------------HNNNNSSNNN 169
                 6665555555544434555555554444333332222221.........................2222222111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1811  (0.10101); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.37s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 1253.73
//
Query:       EFC37296.1  [L=319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0003   21.0   0.0    0.00088   19.5   0.0    1.8  1  NTP_transf_2  Nucleotidyltransferase domain
     0.0031   17.6   0.7     0.0031   17.6   0.7    3.0  3  Polbeta       Polymerase beta, Nucleotidyltransferase
  ------ inclusion threshold ------
      0.058   13.0   0.0       0.47   10.0   0.0    2.1  2  RlaP          RNA repair pathway DNA polymerase beta family


Domain annotation for each model (and alignments):
>> NTP_transf_2  Nucleotidyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   1.5e-07   0.00088      13      60 ..      43     101 ..      28     145 .. 0.66

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.5e-07
                   T.TSEEEEEHHHHCTTSCTTSSEEEEEEESTTCHHH..........HHHEHHHHHHHHC CS
  NTP_transf_2  13 p.vakvvlfGSyarGtalkgSDiDllvvlpeevsre..........kkeegleklaeii 60 
                     ++ ++l+GS+  + + ++SD Dl+ +  +++  +          +++++l++  ++i
    EFC37296.1  43 NsIINLYLVGSRLYNCHDENSDYDLFMIIQNDFTLPkidklkwfevENDKILLESQKEI 101
                   15899***************************988766655555553333333333333 PP

>> Polbeta  Polymerase beta, Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.7   5.2e-07    0.0031      12      47 ..      44      82 ..      29     149 .. 0.79
   2 ?   -0.3   0.2      0.19   1.1e+03      40      81 ..     154     195 ..     147     199 .. 0.76
   3 ?   -2.1   0.1      0.69   4.1e+03      43      58 ..     262     277 ..     253     302 .. 0.61

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 5.2e-07
                HHHSTTEEEEEE-S------EEEEEEEESS-.....--HHH CS
     Polbeta 12 eielaylFGSrakgkareeSDiDlavllkek.....ldlee 47
                +i+ +yl GSr+ + + e+SD+Dl+++++++        ++
  EFC37296.1 44 SIINLYLVGSRLYNCHDENSDYDLFMIIQNDftlpkI--DK 82
                78999*************************9776432..32 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.19
                 SS---HHHHHHHHHHHHHH.SSSEEEEEETTTS-HHHHHHHH CS
     Polbeta  40 kekldleeelelaaelediklgkkvDlvdlneapplllyeil 81 
                 +++++ ++  +  ++l++ik +++++  +l e++++++ +i 
  EFC37296.1 154 SNNNSNNNNNNDNNNLNEIKNRERIENCILIENEKYFITNIK 195
                 444466666777888999999999999999888899988875 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.69
                 --HHHHHHHHHHHHHH CS
     Polbeta  43 ldleeelelaaeledi 58 
                  ++e+ +++ +++e+ 
  EFC37296.1 262 SHYEYIMSFNNDIEKE 277
                 5566666666666654 PP

>> RlaP  RNA repair pathway DNA polymerase beta family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   7.8e-05      0.47      19      45 ..      44      70 ..      25      77 .. 0.84
   2 ?    0.4   0.0     0.067     4e+02     130     169 ..     213     253 ..     198     315 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 7.8e-05
        RlaP 19 kilyacesGSrawGfpspdsDyDvrfi 45
                +i+ + ++GSr++   +++sDyD+  i
  EFC37296.1 44 SIINLYLVGSRLYNCHDENSDYDLFMI 70
                6888899****************9555 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.067
        RlaP 130 lgmakkqlrrylkge.evrlKkylyvlRpllagrwllekge 169
                  ++ k++ +   +++ +v lK +++ ++ l+ + ++l+ g 
  EFC37296.1 213 NSYIKTKKKLCVEHDlRVGLKSMFHSMKILIFAIQILKFGF 253
                 46667777777666668889999999999998888887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1228  (0.0684924); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2023.70
//
Query:       EFC37297.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
   2.9e-144  480.1   0.4   3.3e-144  479.9   0.4    1.0  1  Glycolytic  Fructose-bisphosphate aldolase class-I


Domain annotation for each model (and alignments):
>> Glycolytic  Fructose-bisphosphate aldolase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  479.9   0.4  1.8e-148  3.3e-144       1     328 [.      13     343 ..      13     344 .] 0.98

  Alignments for each domain:
  == domain 1  score: 479.9 bits;  conditional E-value: 1.8e-148
                 HHHHHHHHHT-TT-EEEEE---HHHHHHHHHCTT----HHHHHHHHHHHHT-TT.GGGTEEEEEE-HHHHT-B-TTS-BHHHHHHHTT-EEEEE----E CS
  Glycolytic   1 ELaetakaivapGkGiLaaDestgtigkrlasigventeenrrayrelLfttdkeleeyisGvilfeetlyqkaddgkplvellkekgiipGiKvdkgv 99 
                 EL +t + +va GkG+LaaDest+tigkr+++i++en e+nr+ayrelLft++ke +++isGvil+eetl+q++ +gk ++ell+e+g++pGiK+d gv
  EFC37297.1  13 ELDKTVEMMVARGKGLLAADESTSTIGKRFEKIQLENIEANRQAYRELLFTAPKEYTQFISGVILYEETLFQSTLSGKAFAELLTESGVVPGIKLDLGV 111
                 899************************************************************************************************ PP

                 EE-TTSSS-EEE---TTHHHHHHHHHHTT--EEEEEEEE--BT.TBS-HHHHHHHHHHHHHHHHHHHHTT-EEEEEEEE-.--SS--HHHHHHHHHHHH CS
  Glycolytic 100 vplagtegetttqGldglaercaqykkdGarFaKWravlkise.ktpselaiqenanvLarYasicqenglvpivepeil.ldGdhdlercqkvtekvl 196
                 ++l+gt+get+tqGld+l++r ++y+++GarFaKWrav+k+s+   ps+l++ +na++LarYa+icq+nglvpivepeil ++G+h++e++ +vt++vl
  EFC37297.1 112 KELPGTDGETATQGLDDLEKRIQKYYARGARFAKWRAVYKVSDnGLPSQLCVAQNAETLARYAAICQQNGLVPIVEPEILvMEGSHNIETSLNVTKRVL 210
                 *****************************************99689*********************************8579**************** PP

                 HHHHHHHHHTT--GGG-EE--B-----TT-S----H.HHHHHHHHHHHHTT--TTS-EEEEB-TT--HHHHHHHHHHHHHTS-.-SSEEEEEESHHHHH CS
  Glycolytic 197 aavykalsdhhvlleGtllkpnmvtpGaecskkatp.eevaeatvtalrrtvPpavpgvvflSGgqseeeatvnLnainklekkkpwaltfsygralqa 294
                 a+v++al +h+v l+ ++lkpnmv pG+++++ka+  +++ae+t+ al+ tvPpav g++flSGgqse++a  +Lnaink++  kpwa+++sygralq 
  EFC37297.1 211 ASVFQALIQHNVNLNRIILKPNMVLPGNNSPTKAEDdKKIAEYTIDALTSTVPPAVRGIMFLSGGQSEQQAVETLNAINKVNAPKPWAISYSYGRALQD 309
                 ******************************999765168************************************************************ PP

                 HHHHHHTT-GGGHHHHHHHHHHHHHHHHHHTTT- CS
  Glycolytic 295 svlkaWkGkkenvkaaqeellkrakanslaalgk 328
                 s++++W+Gkkenv+aaq+++l++ak+ slaa+g+
  EFC37297.1 310 STIRTWAGKKENVEAAQKAYLEQAKKCSLAAKGE 343
                 *******************************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       407  (0.0227007); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2144.32
//
Query:       EFC37298.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-37  127.9   0.9    3.5e-37  126.7   0.3    1.9  2  Sod_Fe_C  Iron/manganese superoxide dismutases, C-terminal do
    5.1e-25   87.8   2.1    9.4e-25   86.9   2.1    1.5  1  Sod_Fe_N  Iron/manganese superoxide dismutases, alpha-hairpin
  ------ inclusion threshold ------
      0.068   13.3   0.0       0.14   12.2   0.0    1.5  1  DUF5617   Domain of unknown function (DUF5617)


Domain annotation for each model (and alignments):
>> Sod_Fe_C  Iron/manganese superoxide dismutases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.55   3.3e+03      78      94 ..      53      69 ..      47      75 .. 0.80
   2 !  126.7   0.3   5.9e-41   3.5e-37       5     101 ..     127     222 ..     124     223 .. 0.97

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.55
                HHTT-HHHHHHHHGGGB CS
    Sod_Fe_C 78 dyqnkradYieafwnvv 94
                +y+++ + Y++++  +v
  EFC37298.1 53 HYNKHHKTYVDKLNALV 69
                57888899999987776 PP

  == domain 2  score: 126.7 bits;  conditional E-value: 5.9e-41
                 HHHHHHHHHSSHHHHHHHHHHHHHHSSSSEEEEEEEETTTEEEEEEEETTTBGGGGTTCEEEEEE-SGGGTHHHHTT-HHHHHHHHGGGBBHHHHHH CS
    Sod_Fe_C   5 laeaieedfgslekfkkefkaaalavfgsGwawLvldkkkkLeivttknqdnplvkeakplLalDvwehAYyldyqnkradYieafwnvvnWkevee 101
                 ++++ie++fgs+++fk++f+++a+++fgsGw+wLvld + +L+i + +n+++p++++  plL++DvwehAYyld+qn+r+dY+++fw+ vnW +v++
  EFC37298.1 127 IKQEIEKQFGSVDAFKQQFTEKATTLFGSGWTWLVLDGT-SLRIWNGSNAQTPIAENLIPLLTCDVWEHAYYLDHQNRRPDYLKTFWEAVNWGFVNK 222
                 6899********************************977.*******************************************************97 PP

>> Sod_Fe_N  Iron/manganese superoxide dismutases, alpha-hairpin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.9   2.1   1.6e-28   9.4e-25       1      81 [.      27     114 ..      27     115 .. 0.94

  Alignments for each domain:
  == domain 1  score: 86.9 bits;  conditional E-value: 1.6e-28
                 S------SS-TTT.TTTTS-HHHHHHHHHTHHHHHHHHHHHHHHCHHHHCHCCHHHHHH......HHHHHHHHHHHHHHHHHHHHHTB CS
    Sod_Fe_N   1 kyeLpeLpYayda.LePhisketlelHhdkHhktYvnnlNkalekleeakkkleelvlk......klekalrnnagghvnHslfwknl 81 
                 k++Lp L+Ya++  + P+i++++l++H++kHhktYv++lN+++e++++++++l+++++k       ++ a++nna++h nHs++wk+l
  EFC37298.1  27 KHQLPTLDYAVEQgIHPVITARQLDFHYNKHHKTYVDKLNALVEGTSFESQPLDAIIQKvaydsdPKSVAIFNNAAQHFNHSFYWKSL 114
                 69********97449******************************************9999998777889****************98 PP

>> DUF5617  Domain of unknown function (DUF5617)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   2.4e-05      0.14      25      67 ..      33      75 ..      15      88 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.4e-05
                HHHHTTSTTT-GGGGGGGGSTTHHHHHHHHHHHHHHHHTT--S CS
     DUF5617 25 ndYtkennllgsllgriftgHWnRHhvkavdkivkeidkgnyt 67
                 dY  e+ ++  +  r + +H+n+Hh   vdk+ + ++ + ++
  EFC37298.1 33 LDYAVEQGIHPVITARQLDFHYNKHHKTYVDKLNALVEGTSFE 75
                48999999999999*****************996555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       464  (0.0258799); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1572.78
//
Query:       EFC37299.1  [L=255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0073   16.0   6.6      0.014   15.1   3.1    2.8  2  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.12   12.4   5.2      0.075   13.0   3.1    1.7  2  Mistic    Membrane-integrating protein Mistic
       0.14   12.5   0.1       0.36   11.2   0.0    1.8  2  TrmE_N    GTP-binding protein TrmE N-terminus


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   3.1   2.3e-06     0.014       9      44 ..       2      37 ..       1      41 [. 0.90
   2 ?    1.0   0.5     0.058   3.5e+02      25      32 ..      42      49 ..      32      63 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.3e-06
     DUF4116  9 vkkngsalkylseeLknDkeivlkAvkqngtalsya 44
                +k +++++  ls+e+kn ke+   A+++ +++l+y+
  EFC37299.1  2 LKYYPNYYSQLSDEFKNEKEFKAIAMENLKCNLKYF 37
                799******************999999888999986 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.058
     DUF4116 25 nDkeivlk 32
                nD e+v++
  EFC37299.1 42 NDDEFVMA 49
                89999997 PP

>> Mistic  Membrane-integrating protein Mistic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   3.1   1.2e-05     0.075      14      64 ..      28      79 ..      18      81 .. 0.84
   2 ?   -3.6   0.0       1.9   1.2e+04      50      59 ..     125     134 ..     115     137 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
                HHHHHHHHH--.SSS-SS-SS-SHHHHHHHHHHHHHHTSSSS-HHHHHHHHH CS
      Mistic 14 egldafieLYN.eseedkpliefeeevleaiekAkekYGeevvnkKiNtivk 64
                e l   ++ +N e ++d+ ++ ++ +  ++i+  k+kYG+e ++++i +i +
  EFC37299.1 28 ENLKCNLKYFNvENNDDEFVMALSGNFKRNIKILKSKYGKENIKERIKRIFQ 79
                6677777888856677888999*************************99976 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.9
                 TSSSS-HHHH CS
      Mistic  50 YGeevvnkKi 59 
                 +G+ ++ kKi
  EFC37299.1 125 HGTPAIVKKI 134
                 5666666666 PP

>> TrmE_N  GTP-binding protein TrmE N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   6.1e-05      0.36      59      90 ..     104     135 ..      50     149 .. 0.84
   2 ?   -2.3   0.0       0.9   5.4e+03      38      51 ..     176     194 ..     158     222 .. 0.50

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6.1e-05
                 EEEEEBTTCSTTSSEEEEEEEESSHHHHHHHH CS
      TrmE_N  59 lvlvfkaprsyTgedvvElhlhGgpavvkavl 90 
                 + l+ + ++ +T +d +E+  hG pa+vk++ 
  EFC37299.1 104 CYLYTDMEHVFTIQDQIEMIDHGTPAIVKKIA 135
                 56788899*********************985 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.9
                 CTEEEEEEEECT....... CS
      TrmE_N  38 prkallgklvdee.....e 51 
                 +++a+++ l ++      +
  EFC37299.1 176 SHQAVYRALDRTFitlqkS 194
                 4444444332221222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1102  (0.0614647); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1645.40
//
Query:       EFC37300.1  [L=257]
Description: hypothetical protein NAEGRDRAFT_81935 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1640.62
//
Query:       EFC37301.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-28   99.8   0.1    3.3e-28   99.0   0.1    1.4  1  RNA_ligase      RNA ligase
  ------ inclusion threshold ------
      0.012   15.3   0.2       0.11   12.2   0.2    2.3  1  DNA_ligase_A_M  ATP dependent DNA ligase domain
       0.07   12.7   0.0        5.7    6.5   0.0    2.2  2  AHJR-like       REase_AHJR-like
       0.11   12.3   0.0       0.22   11.3   0.0    1.4  1  RNA_lig_T4_1    RNA ligase


Domain annotation for each model (and alignments):
>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.0   0.1   7.4e-32   3.3e-28       2     160 ..     164     327 ..     163     328 .. 0.87

  Alignments for each domain:
  == domain 1  score: 99.0 bits;  conditional E-value: 7.4e-32
                 EEEEEEE-SSEEEEEEEETT.EEEEETTCEBCTTTHHHHHHTHHHHHHHHHHHHH....ECCEEEEEEEES.SS.......TTSS.EEEEEEEEEEECT CS
  RNA_ligase   2 evvvtEKlDGtnfriylvke.vgvasRsqilpfgeekfkefkrwaaalrkklkekla..neelilyGElighsi.....kygglpkefyvFdifdirdk 92 
                 ++ vt+KlDG+++++y  ++ +gv+ R+ +l    ++  ++ +w+a +r+k+ e l+  n++l+l+GE+ig+si     k     ++fy+Fdi+di+  
  EFC37301.1 164 KFEVTVKLDGSSMTVYRKDDhIGVCGRNWEL----RETATNAQWHAVRRNKMIEGLQflNRNLALQGEIIGESIqgnleKL--KGQDFYLFDIYDID-- 254
                 789**************9667**********....678889*********9999999**889************6643222..335**********9.. PP

                 TBECE--HHHHHHHHHCCT.......B..EEEEE.SS.HHHHHCCC.....HHHHTC--EEEEEESSSSBETTEBSEEEE CS
  RNA_ligase  93 eeqrylspdevealakglg.......tvpvlyegkfl.aaeellel...l.lskgnkrEGlVikpeselyknkgraifKv 160
                  + +yl+p e++ l k+l+       +vp+l   + + +ae++l++   + l+k+ krEGlV+k  ++      +++fK+
  EFC37301.1 255 -KAQYLTPIERQSLVKQLNdngftvkHVPILDDLELNhTAEQILAMadgPsLNKNVKREGLVFKRLDG------KFSFKA 327
                 .**********99999887888999******9999988888888889885448899********8877......777776 PP

>> DNA_ligase_A_M  ATP dependent DNA ligase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.2   2.4e-05      0.11      13      82 ..     156     230 ..     147     337 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.4e-05
                     HHHHTTTSEEEEEEEESSEEEEEEEETTEEEEEETTS-...B-GG...GCHHHHHHHHHHBSTTESEEEEEEEEEE CS
  DNA_ligase_A_M  13 alkkleekafivEiKyDGeRaqvhkegdkvklfSRrlk...dita...akpelvkalkeafkkdeksvilDGElva 82 
                      ++++++++f v +K+DG  + v +++d++ +  R+ +   + t+   +  +  k+++ + +   +++ l GE++ 
      EFC37301.1 156 QIEENKGQKFEVTVKLDGSSMTVYRKDDHIGVCGRNWElreTATNaqwHAVRRNKMIEGLQFL-NRNLALQGEIIG 230
                     5678899****************************9652215555665555566666555555.589999999985 PP

>> AHJR-like  REase_AHJR-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0    0.0013       5.7      64     105 ..     142     183 ..     126     200 .. 0.82
   2 ?    3.9   0.0    0.0082        37      14      36 ..     265     287 ..     254     301 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0013
   AHJR-like  64 rssaseqyLqelakaveqhpgWrfelvmtndedatvsikaee 105
                 +s++ ++  q+l  ++e+ +g +fe++++ d  ++ ++++++
  EFC37301.1 142 ISKTDQERVQNLIPQIEENKGQKFEVTVKLDGSSMTVYRKDD 183
                 67889999*******************988877777766655 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.0082
   AHJR-like  14 eslaeqyrekGyevllhPnredl 36 
                 +sl +q++++G++v   P  +dl
  EFC37301.1 265 QSLVKQLNDNGFTVKHVPILDDL 287
                 6899***********99988886 PP

>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0     5e-05      0.22      28     212 ..     148     326 ..     146     332 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5e-05
  RNA_lig_T4_1  28 EveetkweeieqktqgpyelteKenGclilisalsdgklvvaSkhsleaeshaevgerllekklekegkteeeLaeelleknlTavfElcddsfeeh 124
                   E+ ++   +ie+++ +++e+t K +G+  +++  +d+++ v+ ++   +e+ +++  + +++     +k  e L  + l++nl +  E++ +s + +
    EFC37301.1 148 ERVQNLIPQIEENKGQKFEVTVKLDGSSMTVY-RKDDHIGVCGRNWELRETATNAQWHAVRR-----NKMIEGL--QFLNRNLALQGEIIGESIQGN 236
                   5666677799**********************.9999******9988444444444444444.....3333444..456888888889999988887 PP

  RNA_lig_T4_1 125 ivaypeekagLyLhglnentp.efstes.seevakfakefgfiktklitlesle...evkkfleevaetgswege.eiEGfVvrc.kskkdffFk 212
                     +   + +  yL ++ +  + ++ t    +++ k  ++ gf ++++  l++le   +++++l ++a+  s +++ + EG V +  +  k f Fk
    EFC37301.1 237 LEKL--KGQDFYLFDIYDIDKaQYLTPIeRQSLVKQLNDNGFTVKHVPILDDLElnhTAEQIL-AMADGPSLNKNvKREGLVFKRlDG-K-FSFK 326
                   7777..567779999998888666665557777788888888888888888887664444444.455555544334889999887444.4.4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.36s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 1848.56
//
Query:       EFC37302.1  [L=569]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-07   31.8   0.0    0.00027   21.2   0.0    2.5  2  Ank_5     Ankyrin repeats (many copies)
    2.8e-06   27.8   0.0    9.7e-06   26.0   0.0    1.9  1  Ank_4     Ankyrin repeats (many copies)
    0.00019   21.6   0.2     0.0066   16.9   0.0    2.9  2  Ank_3     Ankyrin repeat
    0.00025   21.6   0.0     0.0015   19.1   0.0    2.3  1  Ank_2     Ankyrin repeats (3 copies)
     0.0013   19.1   0.0     0.0069   16.8   0.0    2.2  2  Ank       Ankyrin repeat
  ------ inclusion threshold ------
        2.1    8.4   7.3        2.1    8.3   0.0    4.0  4  DUF3447   Domain of unknown function (DUF3447)


Domain annotation for each model (and alignments):
>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0    0.0013       3.9      22      45 ..      31      54 ..      31      60 .. 0.87
   2 !   21.2   0.0   9.1e-08   0.00027       9      44 ..      81     117 ..      78     119 .. 0.90

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0013
       Ank_5 22 vAakygaadvvrlLlargadlnlt 45
                +A++ g++d+v+++l++++d++  
  EFC37302.1 31 LAIWIGNLDLVKWCLEYRSDNGNN 54
                59999***************9865 PP

  == domain 2  score: 21.2 bits;  conditional E-value: 9.1e-08
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLl.argadlnl 44 
                 +  +dg g ++Lh+A+++ + ++v+lL+ ++ a++++
  EFC37302.1  81 CYKRDGAGLNILHYAIRGKNVEIVKLLIeKYKANPFQ 117
                 67789***********************999998875 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.0   0.0   3.3e-09   9.7e-06      12      55 .]      36     108 ..      30     108 .. 0.96

  Alignments for each domain:
  == domain 1  score: 26.0 bits;  conditional E-value: 3.3e-09
       Ank_4  12 grlelvrlLlekgad..............................inaqdnrsGetalhiAakrgnveilklLl 55 
                 g+l+lv+++le++ d                              ++++ ++ G++ lh+A+++ nvei+klL+
  EFC37302.1  36 GNLDLVKWCLEYRSDngnnridtllrtgifegepssynivssygaCYKR-DGAGLNILHYAIRGKNVEIVKLLI 108
                 89********999999999999***************************.***********************8 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.23   6.7e+02      13      27 ..      36      49 ..      30      60 .. 0.83
   2 !   16.9   0.0   2.2e-06    0.0066       2      29 ..      88     115 ..      87     116 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.23
       Ank_3 13 gnleivkfLlenkga 27
                gnl++vk++le +  
  EFC37302.1 36 GNLDLVKWCLE-YRS 49
                8999*******.554 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 2.2e-06
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                 G ++Lh+A+r  n+eivk+L+e++ a++
  EFC37302.1  88 GLNILHYAIRGKNVEIVKLLIEKYKANP 115
                 7899******************998875 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0     5e-07    0.0015      49      77 ..      84     113 ..       3     124 .. 0.55

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 5e-07
       Ank_2  49 adndgrtpLhyAarsghleivklLlek.ga 77 
                  d  g ++LhyA+r ++ eivklL+ek +a
  EFC37302.1  84 RDGAGLNILHYAIRGKNVEIVKLLIEKyKA 113
                 223366666666666666666666654233 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       2.1   6.2e+03       8      22 ..      31      45 ..      31      55 .. 0.80
   2 !   16.8   0.0   2.3e-06    0.0069       5      27 ..      91     115 ..      88     119 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.1
                HHHHHTTHHHHHHHH CS
         Ank  8 lAatngkkriiklLL 22
                lA+++g+++ +k+ L
  EFC37302.1 31 LAIWIGNLDLVKWCL 45
                78999*999999866 PP

  == domain 2  score: 16.8 bits;  conditional E-value: 2.3e-06
                 HHHHHHHHTTHHHHHHHH..TTTST CS
         Ank   5 PLHlAatngkkriiklLL..hGAnl 27 
                  LH+A+++++++i+klL+  + An+
  EFC37302.1  91 ILHYAIRGKNVEIVKLLIekYKANP 115
                 59*****999********8336998 PP

>> DUF3447  Domain of unknown function (DUF3447)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0       0.2   5.9e+02      12      31 ..      31      50 ..      23      60 .. 0.81
   2 ?    8.3   0.0   0.00072       2.1      34      58 ..      90     114 ..      77     131 .. 0.69
   3 ?   -3.3   0.2       3.1   9.3e+03      38      58 ..     157     172 ..     143     181 .. 0.52
   4 ?   -0.3   0.7      0.36   1.1e+03      23      44 ..     395     416 ..     375     446 .. 0.67

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.2
     DUF3447 12 lsflggnpeIineClkyqkp 31
                l++  gn + ++ Cl+y+  
  EFC37302.1 31 LAIWIGNLDLVKWCLEYRSD 50
                588899*********98754 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00072
     DUF3447  34 kcmeyaiisHnidfvtyLmneynle 58 
                 +++ yai+  n ++v+ L+++y+ +
  EFC37302.1  90 NILHYAIRGKNVEIVKLLIEKYKAN 114
                 5566777777777777777777653 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 3.1
     DUF3447  38 yaiisHnidfvtyLmneynle 58 
                 + + s ++     +++e n++
  EFC37302.1 157 NHVESNKN-----IFDEANMK 172
                 44444444.....33444444 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.36
     DUF3447  23 neClkyqkpdkkcmeyaiisHn 44 
                 n C k+  +d++ +++ ++s  
  EFC37302.1 395 NGCFKESSIDEEALKNHLSSLS 416
                 6688877888777776665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (569 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       888  (0.0495287); expected 358.6 (0.02)
Passed bias filter:                      437  (0.0243739); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3362.21
//
Query:       EFC37303.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00034   20.5   0.0    0.00066   19.6   0.0    1.5  1  SBBP      Beta-propeller repeat
    0.00096   19.1   0.0     0.0022   17.9   0.0    1.6  1  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   7.3e-08   0.00066      14      29 ..      29      44 ..      25      44 .. 0.94

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 7.3e-08
        SBBP 14 ygngIavDsnGNiYvt 29
                +++gI+ Ds GNiYvt
  EFC37303.1 29 SPRGITLDSKGNIYVT 44
                59*************9 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   2.5e-07    0.0022       3      19 ..      29      45 ..      27      51 .. 0.91

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.5e-07
                SEEEEEEETTTEEEEEE CS
         NHL  3 yPhGvavdsnGdiyVaD 19
                +P+G+++ds G+iyV+D
  EFC37303.1 29 SPRGITLDSKGNIYVTD 45
                7**************** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       417  (0.0232584); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.32s 00:00:00.82 Elapsed: 00:00:00.51
# Mc/sec: 898.02
//
Query:       EFC37304.1  [L=302]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.14   11.2   0.0       0.21   10.6   0.0    1.1  1  PPP1R32   Protein phosphatase 1 regulatory subunit 32


Domain annotation for each model (and alignments):
>> PPP1R32  Protein phosphatase 1 regulatory subunit 32
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   1.2e-05      0.21     114     168 ..     149     203 ..     136     212 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 1.2e-05
     PPP1R32 114 vrekpitlptskevkkvhfdtqdagpkaitglepkerplLhklqkkdpvelenar 168
                 vr+  i +p++++ k   +dt d   +    ++ k  p L +l+ +++v++en++
  EFC37304.1 149 VRDLTIKFPNTQNNKYLGIDTADVENNILSAITRKRFPKLLRLSIQGSVSMENLD 203
                 79999**********************99************************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       509  (0.0283898); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1802.48
//
Query:       EFC37305.1  [L=643]
Description: peptidase M1 family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-42  145.9   0.4    2.6e-42  144.9   0.4    1.5  1  Peptidase_M1     Peptidase family M1 domain
    5.6e-38  129.5   0.5    1.6e-37  128.0   0.5    1.9  1  Leuk-A4-hydro_C  Leukotriene A4 hydrolase, C-terminal
    6.2e-22   78.7   5.7    8.1e-21   75.0   5.7    2.3  1  Peptidase_M1_N   Peptidase M1 N-terminal domain
  ------ inclusion threshold ------
      0.046   14.1   0.7          1    9.8   0.7    2.7  1  Peptidase_M61    M61 glycyl aminopeptidase


Domain annotation for each model (and alignments):
>> Peptidase_M1  Peptidase family M1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  144.9   0.4   5.7e-46   2.6e-42       8     217 ..     278     488 ..     272     489 .. 0.79

  Alignments for each domain:
  == domain 1  score: 144.9 bits;  conditional E-value: 5.7e-46
                   HHHHHHHHHHTS--SSSEEEEEEE.SSTTSSEEEETTEEEEEGGGC-SSTTTS-HHHHHHHHHHHHHHHHHHHBTTTEEESSGGGGHHHHHHHHHHH CS
  Peptidase_M1   8 kllefleeyfkvpYplpkldlval.pdfsagAMEnwglityreelllvdpenssesdkrsvaeviaHElaHqWfGnlVtmkwWddlwLnEGfatyle 103
                   +++  ++e+f  pY++ ++d+v+l  ++++g+MEn +l++++++ll+ d         rs+a+v+aHE+aH+W+Gnl+t++ W+d+wLnEGf++++e
    EFC37305.1 278 EAFIKAAEEFLPPYAWGRYDIVLLpSSYPFGGMENSNLTFLTPTLLAGD---------RSLANVVAHEIAHSWSGNLITNSTWEDFWLNEGFTVFIE 365
                   445556677889************668**********************.........99************************************* PP

                   HHHHHHHSC.CCH.CHHHH....HHHCHHHHHHHHTSTTHHHSSGG-GSHHHHHHTSSHHHHHHHHHHHHHHHH.HCT.HHHHHHHHHHHHHHCTTE CS
  Peptidase_M1 104 ylildklep.ewe.vseql....lleeveealsedaldeshpitqevekpseidevFdsiaYeKGasllrmlek.llg.eevFqkglksYlkefkyk 192
                   ++il +l++ e+  + +q+    l++++++  + ++l+ ++ i   + ++ ++d++F+s++YeKG+++l +l++ ++g    F+k+l +Y++ f +k
    EFC37305.1 366 RRILARLSGeEYAkFHAQMgyshLVSSINHYKEINELQYTKMI--PLLEKCDPDDAFSSVPYEKGFNFLYYLADqIVGsIPRFEKFLYHYFTVFCQK 460
                   ********96333444444201123444444444444444444..788999********************97526777789*************** PP

                   EE-HHHHHHHHHHCCC..SCHHTH.HHH CS
  Peptidase_M1 193 naetedlwdaleealn..kdisev.mdt 217
                   ++++ ++ + + e  +  ++ +e+ +d+
    EFC37305.1 461 TVNSAEMKKCFLEYFAdvEKTKEIdWDS 488
                   *****99998887433334444445555 PP

>> Leuk-A4-hydro_C  Leukotriene A4 hydrolase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.0   0.5   3.6e-41   1.6e-37       1     113 []     533     642 ..     533     642 .. 0.97

  Alignments for each domain:
  == domain 1  score: 128.0 bits;  conditional E-value: 3.6e-41
                      --HHHHHHHHHHHHTT-GGG-HHHHHHHHHHTIIIT---HHHHHHHHHHHHHTT-GGGHHHHHHHTTT---HHHHHHHHHHHHTT-HHHHHHHH CS
  Leuk-A4-hydro_C   1 fssnqkvlfLekLlekekplpaekleaLdelYklseskNaeirlrwlqlalkakyeeavpevaeflgsqGrmkfvrplYraLnkvdrdlAketF 94 
                      +ss+q+++fL+ Ll+++kpl   ++++Lde+Y++s+ +N+eir+ w +la+k+kye++ p+v++f++ qGrmk+vrplYr+L+k+d++lA++tF
       EFC37305.1 533 WSSTQLTYFLDILLSNDKPL---NVQKLDETYEYSKYTNSEIRFGWQMLAIKHKYEPVKPQVVAFITMQGRMKYVRPLYRELFKFDAELARSTF 623
                      9**************99555...59********************************************************************* PP

                      HHHGGGS-HHHHHHHHHHT CS
  Leuk-A4-hydro_C  95 ektkdfyhpiarklvekdL 113
                      +++k fyh iark++ekdL
       EFC37305.1 624 QQYKGFYHGIARKMIEKDL 642
                      *****************98 PP

>> Peptidase_M1_N  Peptidase M1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.0   5.7   1.8e-24   8.1e-21       3     186 .]      33     241 ..      31     241 .. 0.71

  Alignments for each domain:
  == domain 1  score: 75.0 bits;  conditional E-value: 1.8e-24
                     EEEEEEEEEETTTTEEEEEEEEEEEES.S-ECEEEEEESSEEEECEEEEECTTCTCEEEEEEEECTTTTC..EEEEECCEEET.......TCEEE CS
  Peptidase_M1_N   3 ehYdldlkidlkektfkGsvtitlqlk.eatseivldakdlkiksvslsaevksesvkidfkieqkdeel..ltiklkeslqq.......tskyt 87 
                      hY +dl++d+k+k + G v +t+++     s++v+da++l ik+ +++ +++++ ++ + +++q +e+   +++  k+++ q        ++++
      EFC37305.1  33 HHYYMDLTTDFKNKILVGYVDVTFEALiDRPSHVVVDARNLVIKQTKFLYKKHHKHSEDNINEQQHQEHElaFRVFSKSEVAQngypsvyGEPLS 127
                     6999***********************999*************9998886555555443333333333324544444444444455555544444 PP

                     EEEEEEEE-................BSSSSEEE....EEEEEE.TSCEEEEEEEE-TTTTGGGTS-B--STTSEBEEEEEEEEETTSEEEESSEC CS
  Peptidase_M1_N  88 Leieyegel................ndklaGly....kstYtd.kgekkvvvvTqfeatdARsafPCfDePsvKAtftisikapkeetalSnmpe 161
                     ++ + e+ +                + + ++++    +    +  g+  ++++Tq++a++ARs++PC+D+Ps+K t++ +i++pk+   ++ m+ 
      EFC37305.1 128 MSLTHEA-VdleagnffvvrifyetTHESEAIQwlepE----QtLGKVHPYLFTQCQAIHARSLLPCQDTPSNKITYSSTIRTPKPL--VAAMSA 215
                     4444444.122333334444444448888888865433....338999**************************************5..444444 PP

                     CCE.EEETTCEEEEEEEEEESBEGGG CS
  Peptidase_M1_N 162 ees.eklengqkiteFeqtpkmstYL 186
                     +++ e+     +i++F+q + +++YL
      EFC37305.1 216 IKQwEDVSTHINIYHFKQNVTIPSYL 241
                     444144445677*************9 PP

>> Peptidase_M61  M61 glycyl aminopeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.7   0.00023         1       3      56 ..     330     372 ..     328     404 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00023
                    HHHHHHHHHHTTBTTTB-BGGGSS---SS----STHHHHTHHHHHHHHHHHHHT CS
  Peptidase_M61   3 lgllaHEyfHsWnvkrirPaelepfdyekenytellwvaEGlTsYygdlllars 56 
                    ++++aHE  HsW ++ i  ++            e  w+ EG+T +++  +lar 
     EFC37305.1 330 ANVVAHEIAHSWSGNLITNSTW-----------EDFWLNEGFTVFIERRILARL 372
                    6789999999999987765544...........567999999999998888885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (643 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       745  (0.0415528); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3853.58
//
Query:       EFC37306.1  [L=496]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-16   60.3  11.7      4e-16   59.3   9.2    2.5  2  RGS           Regulator of G protein signaling domain
    3.1e-06   26.7   0.0    5.6e-06   25.9   0.0    1.5  1  START         START domain
  ------ inclusion threshold ------
      0.045   13.7   0.2       0.14   12.2   0.2    1.8  1  Tfb5          Transcription factor TFIIH complex subunit Tfb5
       0.47   10.0   9.4        0.8    9.3   9.4    1.3  1  SR-25         Nuclear RNA-splicing-associated protein
        1.5    9.4  11.4        1.1    9.9   7.8    2.2  2  Secretin_N_2  Secretin N-terminal domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.3   9.2   1.1e-19     4e-16       2     118 .]      21     146 ..      20     146 .. 0.97
   2 ?    0.3   0.0      0.23   8.1e+02      37      69 ..     451     483 ..     401     495 .. 0.72

  Alignments for each domain:
  == domain 1  score: 59.3 bits;  conditional E-value: 1.1e-19
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.........STTTTTTH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke.........qpsrklfe 91 
                 +e +++ +  ++ Fr Fl++e++e+ + F++++eefk+ k +e+  kka  ++++++ p+s +e+ni+++ r+ + + ++++           + ++f+
  EFC37306.1  21 FEAIFDVPEAKEEFRLFLKKEHNEDPFLFFQETEEFKRLKFEENKAKKAITLFERFILPNSRQEINISSQQRQDIIHSFSDVsqlldekhlLVNDNVFD 119
                 678999999************************************************************************9*******99999***** PP

                 HHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS  92 eaqeevfellekdsypkFlkselylrl 118
                 ++q +vf  l++d yp+F  se ++++
  EFC37306.1 120 QVQLSVFCNLKSDNYPRFTMSEQFKKF 146
                 ************************986 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.23
                 HHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS- CS
         RGS  37 fkkakeqeelkkkakeIyneylapsspkelnid 69 
                 fk+ k +e l+++++e  ++yl++  p el+ d
  EFC37306.1 451 FKRPKFSEGLLETFDEFKSTYLSETNPVELSWD 483
                 555588888888888889999988888887655 PP

>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.0   1.6e-09   5.6e-06      93     163 ..     281     349 ..     209     370 .. 0.81

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 1.6e-09
                 EEEEEEE--TT..-SS-EEEEEEEEEEE..TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTC CS
       START  93 alqlyvaelvalsplspRdfvflRsire.lgdgsyvivdrSvtseqnppesssvvRaellpSgilieplgng 163
                  l++   el +   l+pRd+v + ++    +++ +vi+  S++   +p+ ++s vRa++l+Sg+  + ++n 
  EFC37306.1 281 HLYVNMRELSW--ILKPRDVVLAVTCVFdRKRDCLVIAKKSTETVLMPE-KKSHVRAQMLTSGFFCDCSPNE 349
                 45555667778..**********9999955677778999**********.8*************98777766 PP

>> Tfb5  Transcription factor TFIIH complex subunit Tfb5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.2   3.8e-05      0.14      33      65 ..     102     134 ..      85     137 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 3.8e-05
        Tfb5  33 iiedLDethlfvkeevveelkkeleelleknty 65 
                 + + LDe+hl+v+++v ++++  +   l++ +y
  EFC37306.1 102 VSQLLDEKHLLVNDNVFDQVQLSVFCNLKSDNY 134
                 56789***************9988777777666 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   9.4   0.00022       0.8      34      91 ..     344     401 ..     316     449 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00022
       SR-25  34 sksqsrkassasekeeerskekkkkkrrrssssssssssssssssssssssssddrkk 91 
                   s+++k  s++++++++s+  ++  r++s++ss sss s+ sss+ s s   +++ +
  EFC37306.1 344 DCSPNEKIVSVKKSNDKQSTGSSQLDRKNSNASSLSSSVSTASSSTLSCSPNISQNGQ 401
                 4566777777887777888888888888888888888888777776666554444222 PP

>> Secretin_N_2  Secretin N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.41   1.5e+03      62      74 ..     189     201 ..     185     203 .. 0.83
   2 ?    9.9   7.8    0.0003       1.1      17      74 ..     357     416 ..     349     420 .. 0.55

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.41
  Secretin_N_2  62 etesesdfwgeLq 74 
                     ++e+d+w+e++
    EFC37306.1 189 AFSKETDVWDEIK 201
                   6789*******98 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0003
  Secretin_N_2  17 sntsvtsGsvsssgssssssssssss.sgsssssssssnss........sgtkietesesdfwgeLq 74 
                   sn + ++Gs +  +++s+ ss ss s s  +sss+              +g++++t+ +  f+ +++
    EFC37306.1 357 SNDKQSTGSSQLDRKNSNASSLSS-SvST-ASSST-----LscspnisqNGQETYTKLTLLFFVDIK 416
                   333333333333333333333322.3122.22233.....133444889**************9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1112  (0.0620224); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.43
# Mc/sec: 3468.01
//
Query:       EFC37307.1  [L=748]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    9.1e-16   57.9   0.1    3.5e-15   56.0   0.1    2.0  1  Ras        Ras family
     0.0014   18.8   0.1     0.0059   16.8   0.1    2.1  1  Roc        Ras of Complex, Roc, domain of DAPkinase
     0.0068   15.5   1.1      0.011   14.8   1.1    1.3  1  BAF1_ABF1  BAF1 / ABF1 chromatin reorganising factor


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.0   0.1   5.9e-19   3.5e-15       4     156 ..     587     737 ..     585     743 .. 0.87

  Alignments for each domain:
  == domain 1  score: 56.0 bits;  conditional E-value: 5.9e-19
                 EEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSG.GGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHS CS
         Ras   4 lvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqe.efkslrelyyrdaegillvyditsresfenvkkwveeikrva 101
                 + G  + GKtsl+  ++ ++F+ +   T  +++  +++e    ++ +++ D    + e ++++++++ +++ ++++y++++ +sf+ ++++++ ik+++
  EFC37307.1 587 ICGGDHPGKTSLISTYMFGQFDATAYDTS-INESYRKVE---GNYVIDLKDSSSRNlEEEKINKSFIGKSDIFIICYSVKNLNSFKMARDYIDYIKTIK 681
                 6788899***************9998888.555555554...56789999*9998746789*************************************9 PP

                 TTTSEEEEEEETTTGGG.G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHH CS
         Ras 102 eenvpivLvGnKvDlee.kravsteegeelakelg.lkfletSAktnenveeafeel 156
                 + n  +++ + ++D  +   +v+t++g +la++++ ++f+e+S     nv+++f++ 
  EFC37307.1 682 T-NPILLIAALQCDSPKsIWKVTTQDGLKLANDYDdAQFFEISSYLGINVRDIFMSG 737
                 9.577777789***9773679*************99******************975 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   9.9e-07    0.0059       3     119 ..     586     694 ..     585     695 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 9.9e-07
                 EEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTT.TT-HHHHCTSCEEEEEEE...GHHHHCHHH CS
         Roc   3 vlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfr.slhplylreaalailvyd...srssenlke 97 
                  ++G  + GKtsl++ ++ ++f+ +   t   + ++k    ++g        ++ +++ D +  +  + +++++++ +++++i++y     +s++ +++
  EFC37307.1 586 WICGGDHPGKTSLISTYMFGQFDATAYDTSINESYRK----VEG--------NYVIDLKDSSSRNLEEeKINKSFIGKSDIFIICYSvknLNSFKMARD 672
                 68999999**************988666654444333....334........356888999998755417****************9533345677899 PP

                 HHHHHHHHCSSS-EEEEEE-TT CS
         Roc  98 WlkelkkvagkspvilvgnkiD 119
                 +++ +k+  ++ ++++ + ++D
  EFC37307.1 673 YIDYIKTIKTNPILLIAALQCD 694
                 ****999999988888877776 PP

>> BAF1_ABF1  BAF1 / ABF1 chromatin reorganising factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   1.1   1.8e-06     0.011     286     362 ..     435     529 ..     424     646 .. 0.59

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.8e-06
   BAF1_ABF1 286 eeSgildilkerYgLtdedldKkllsqiaRrvTTYKARFVLkkKknGeyk................vssanknenkdns......qekkeeslesteaa 362
                 ++  + d+lk   +L d++++K+l+s++aRrvT        k  +  ++                 ++ +n+++++ +s      +    +  es+ a+
  EFC37307.1 435 DDKNLQDLLKISSKLGDKEFSKQLTSLMARRVTDSNSYKFFKIAQDFKITsltdlcnlftqlekykKEHTNNTNQRRRSlavvlkR----NPSESNLAD 529
                 77889****************************64443334443333333333555555554433211111111111112222211....111222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (748 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       832  (0.0464053); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 4398.80
//
Query:       EFC37308.1  [L=294]
Description: Hypothetical protein NAEGRDRAFT_81938 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (294 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       532  (0.0296726); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1868.58
//
Query:       EFC37309.1  [L=275]
Description: PAP2 family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-12   46.5   2.6    3.3e-12   46.5   2.6    1.5  2  PAP2_3    PAP2 superfamily
    4.6e-05   23.2   2.8    4.6e-05   23.2   2.8    2.6  2  PAP2      PAP2 superfamily
  ------ inclusion threshold ------
      0.035   14.6   0.8      0.035   14.6   0.8    3.3  3  PAP2_C    PAP2 superfamily C-terminal
        0.2   11.3   0.0        0.2   11.3   0.0    2.3  3  TRAM1     TRAM1-like protein
       0.41   10.1   3.3       0.84    9.1   3.1    1.7  1  DUF1129   Protein of unknown function (DUF1129)
        1.8    8.5   7.2        3.3    7.7   1.9    2.3  2  DUF679    Protein of unknown function (DUF679)


Domain annotation for each model (and alignments):
>> PAP2_3  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1       1.4     4e+03      66      77 ..      47      58 ..      37      84 .. 0.62
   2 !   46.5   2.6   1.1e-15   3.3e-12      36     188 ..     129     272 ..     105     274 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.4
      PAP2_3 66 lllatllgllvy 77
                l++++++ +++ 
  EFC37309.1 47 LFVMVVVISISQ 58
                333333333333 PP

  == domain 2  score: 46.5 bits;  conditional E-value: 1.1e-15
      PAP2_3  36 Yaslhfqvtllvlvllf.lrrrerlreflttlllatllgllvyalfPaagPrlleeagfvdtvaaaslagalrdgasravllrgt..ienglaafPSlH 131
                 Y + +f  ++++  l+  +++ e   ++ + +l+++++ +lv++ fP++ P      ++ ++ ++++ + ++ d+++ ++ ++++  +  +  a+PS H
  EFC37309.1 129 YLY-TFGDLFIMSCLIPtSPNLETIIRIFFGMLVVCVMQCLVFLIFPSTIP-----DNYRHAIDEYQTKYGKIDSYT-YSFYKKMygVDLHANAIPSGH 220
                 553.333344444444448889999999999********************.....455555555555553333333.3334444003456667***** PP

      PAP2_3 132 vawallvalalwrlrrkrllrvlalllnvlmivatvatgnHYlvDviaGvalalvai 188
                 + +a+ +a++     ++ +l+++ ll+++l+++++v t  H ++D i+G++++l+++
  EFC37309.1 221 CSIATYLAMT-----QWNVLGPITLLNPLLIAISCVCTKQHAALDTIVGILFGLLIY 272
                 *****99999.....88889*********************************9987 PP

>> PAP2  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.5       1.5   4.5e+03      81      81 ..      66      66 ..      45      95 .. 0.46
   2 !   23.2   2.8   1.6e-08   4.6e-05      14     124 ..     160     272 ..     149     275 .] 0.68

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.5
        PAP2 81 k 81
                +
  EFC37309.1 66 Q 66
                2 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 1.6e-08
        PAP2  14 lltsvlKdlvgrpRPfflaeetkldtqvstletses..........keakesf..........PSgHsafafalalllalllrrkrkkiglvllalill 92 
                 l++ v+  lv    P+++ ++ ++  + ++     +          k     +          PSgH+++a++la++ + +l++             +l
  EFC37309.1 160 LVVCVMQCLVFLIFPSTIPDNYRHAIDEYQTKYG-KidsytysfykK-----MygvdlhanaiPSGHCSIATYLAMTQWNVLGPI------------TL 240
                 5555566666666666666666666665443333.233444444330.....14444455556********99999988888754............56 PP

        PAP2  93 llavlvalsRlylgvHflsDvlaGlliGiala 124
                 l  +l+a+s ++   H   D+++G+l+G+++ 
  EFC37309.1 241 LNPLLIAISCVCTKQHAALDTIVGILFGLLIY 272
                 7899************************9986 PP

>> PAP2_C  PAP2 superfamily C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   1.3      0.44   1.3e+03      14      48 ..      49      87 ..      43      94 .. 0.53
   2 ?   -0.5   0.7      0.64   1.9e+03      31      46 ..     152     167 ..     123     176 .. 0.54
   3 ?   14.6   0.8   1.2e-05     0.035       8      70 ..     218     273 ..     212     275 .] 0.78

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.44
      PAP2_C 14 ltlavlfileyspkkla....ilkvillllallglflii 48
                ++++v+ i +y   ++     +   +++ l+++g+f ++
  EFC37309.1 49 VMVVVISISQYLVGTYLqfnnFSMEMYFALTFVGIFTLV 87
                444444444444444443332344455666666666655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.64
      PAP2_C  31 ilkvillllallglfl 46 
                 i++++  +l++  + +
  EFC37309.1 152 IIRIFFGMLVVCVMQC 167
                 3444333333222222 PP

  == domain 3  score: 14.6 bits;  conditional E-value: 1.2e-05
      PAP2_C   8 SGHtvvltlavlfileyspkklailkvillllallglfliiasrkHYtvDVllglyittlvfl 70 
                 SGH  + t ++++ ++       +l  i+ll  ll+ ++++++++H  +D ++g+++  l++ 
  EFC37309.1 218 SGHCSIATYLAMTQWN-------VLGPITLLNPLLIAISCVCTKQHAALDTIVGILFGLLIYS 273
                 6666655555555554.......567778999999999*********************9994 PP

>> TRAM1  TRAM1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   6.6e-05       0.2      14      41 ..      29      56 ..      14      65 .. 0.84
   2 ?   -3.0   0.2       1.9   5.8e+03      32      42 ..     155     165 ..     153     172 .. 0.77
   3 ?   -2.9   0.9       1.9   5.7e+03      15      35 ..     181     203 ..     168     203 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6.6e-05
       TRAM1 14 sansetglYgkGlkDlafvffyvivftf 41
                +++++t+  + G+kDl ++f +v+v ++
  EFC37309.1 29 EKSTSTPNHHDGVKDLITLFVMVVVISI 56
                56789999*****************997 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.9
       TRAM1  32 vffyvivftfl 42 
                 +ff ++v +++
  EFC37309.1 155 IFFGMLVVCVM 165
                 78888888775 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 1.9
       TRAM1  15 ansetglYg..kGlkDlafvffy 35 
                 +  + ++Y+  +G  D ++  fy
  EFC37309.1 181 YRHAIDEYQtkYGKIDSYTYSFY 203
                 44444455422566777777776 PP

>> DUF1129  Protein of unknown function (DUF1129)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   3.1   0.00028      0.84      67     150 ..      29     115 ..      15     169 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00028
     DUF1129  67 kkakkesk...enpwlmalDnsLlllalfallfgilalfskkkqtasiGlitlllvalvgGlamvlvyrlltrekkkkkrpplwkrl 150
                 +k   +++     + l+ l  + +++++   l+g    f++ +++ +  l+ + +++lvgG+ +++  + +  ++ ++k+  ++   
  EFC37309.1  29 EKSTSTPNhhdGVKDLITLFVMVVVISISQYLVGTYLQFNNFSMEMYFALTFVGIFTLVGGFELYFKTQRIVISNYQSKKDYIIAHS 115
                 33333333333455677788899999999*********************************8887665554445555555554443 PP

>> DUF679  Protein of unknown function (DUF679)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.3      0.02        59      80     159 ..      21      99 ..       2     104 .. 0.70
   2 ?    7.7   1.9    0.0011       3.3     114     157 ..     132     176 ..     105     185 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.02
      DUF679  80 nkekedeeeklekyrlrllDfvhAflsvvvFlavalsdknvvkClfpeaeeetkellknlPlgvgvlssfvfvifPttRk 159
                 n+ ++ +++++++   +  D v+ +++++v ++v   ++ +v  +++ ++ +++  +    +g+ +l++ + + f t+R 
  EFC37309.1  21 NS-STINSKEKSTSTPNHHDGVKDLITLFVMVVVISISQYLVGTYLQFNNFSMEMYFALTFVGIFTLVGGFELYFKTQRI 99 
                 22.2355557888888999***************9999999998887655555555555556677777777777777775 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0011
      DUF679 114 alsdknvvkClfpeaeeetkellknl..PlgvgvlssfvfvifPtt 157
                 ++ d  +++Cl+p+ + + +++++ +   l+v v+ ++vf+ifP+t
  EFC37309.1 132 TFGDLFIMSCLIPT-SPNLETIIRIFfgMLVVCVMQCLVFLIFPST 176
                 56788899*****9.666777777763358899999********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       971  (0.0541581); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 1778.05
//
Query:       EFC37310.1  [L=325]
Description: epoxide hydrolase-related protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-15   58.0   0.0    5.3e-12   45.9   0.0    2.1  2  Abhydrolase_1  alpha/beta hydrolase fold
      1e-11   45.9   0.0    1.5e-11   45.4   0.0    1.1  1  Abhydrolase_6  Alpha/beta hydrolase family
    3.7e-05   23.1   0.0     0.0039   16.5   0.0    2.1  2  Hydrolase_4    Serine aminopeptidase, S33
  ------ inclusion threshold ------
      0.055   13.1   0.0       0.17   11.5   0.0    1.7  2  FSH1           Serine hydrolase (FSH1)
      0.094   12.4   0.0       0.14   11.8   0.0    1.2  1  PGAP1          PGAP1-like protein


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.9   0.0   1.5e-15   5.3e-12       1     109 [.      17     134 ..      17     151 .. 0.88
   2 !   10.3   0.0   0.00011      0.38     183     255 ..     228     309 ..     167     311 .. 0.66

  Alignments for each domain:
  == domain 1  score: 45.9 bits;  conditional E-value: 1.5e-15
                    SEEEEE-STTTCGGG.GTTGHHHHHHHHT.......TSEEEEEEETTSTTSSSTTTGB.CHHSHHHHHHHHH.HH..HHHCTTSSEEEEEETHHHH CS
  Abhydrolase_1   1 pvlvilhGlpgssdv.waerglapaLakd.......gfdvillDlrGvgySspapacinddygtasvaddld.ri..ldalgddkltlvGhSmGGm 85 
                    p++++lhG+p  +   w      +++ak+       +f + ++DlrG+  S+++  +  ++y +  +  d++  i    + g +k +lv+h++G  
     EFC37310.1  17 PLIIYLHGFPQAAATcWTY--QLQDFAKRnfkygekRFALMAPDLRGYNTSDKPDITDLNNYDMGELVHDIKgLIegYYKNGKGKAVLVAHDWGAI 110
                    689********88884666..899999999*********************99985433889999999999987789999**************** PP

                    HHHHHHHHHGGGEEEEEEESECSS CS
  Abhydrolase_1  86 ialayaaeyperVkalvllgaidp 109
                    i++ + + ype V +l+ l+ ++p
     EFC37310.1 111 ISWVLTSTYPEVVEKLIVLNVPHP 134
                    *******************99433 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00011
                    HHHHHHHHHHHHCCHHHHHHHHHC....THHHHSEEEEEEETTCSSSCHHHHHHHHHC.......HTSEEEEEEETCSSSHHHH CS
  Abhydrolase_1 183 tgalksieqwpttdsaklllrlre....lknvlaptlvisgtsDplvppkaledlaql.......lpkkrlvvisdagHlafle 255
                    ++a+k + ++p+  + ++ ++  e     ++v++ptl+++g +D +   ++  dl  +        pk ++++ + agH++ le
     EFC37310.1 228 ANAIKMKLGYPDARRYPKVGQTLEapleQQKVKVPTLILWGKDDLALI-EETADLSFKyyidesvKPK-SKIIKFEAGHFIALE 309
                    44444455555555555555555566666779*********7777664.4444444444665556666.999999999999876 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.4   0.0   4.1e-15   1.5e-11       2     211 ..      20     308 ..      19     316 .. 0.49

  Alignments for each domain:
  == domain 1  score: 45.4 bits;  conditional E-value: 4.1e-15
                    EEE--GC......G.CHHHHHHHHCCT.......CEEEEE--TTST.S-GGCS--HHHCHHHHHHHCCTT..........TTSEEEEEETCHHHHH CS
  Abhydrolase_6   2 lllHGagss.assW.lvapLaallaag.......vhvlapDlpGhG.rsdpppldledladlaalldelaa........gggpvvlvGHSlGGala 79 
                    + lHG++   a++W +  +L+ ++ +        ++  apDl+G+  ++ p+ +dl++  d  +l++++++        g g++vlv+H++G++++
     EFC37310.1  20 IYLHGFPQAaATCWtY--QLQDFAKRNfkygekrFALMAPDLRGYNtSDKPDITDLNN-YDMGELVHDIKGliegyyknGKGKAVLVAHDWGAIIS 112
                    679**997789***86..77555555544444558999*******5123334466666.4446666666555556777999999**********88 PP

                    HHHHHCC.......EE..EEES-..............----TTT.....S----TTHHHHHH..........TT-CCCCHCCHS-HSCCCCHHHCC CS
  Abhydrolase_6  80 laaapla.....lvvg..vlldppp............talpagl.....laaalelllalla..........llrllawlsreplprlfladedad 141
                    +    l+     +v++  vl  p p                           +  l+ +l+           ++r+la+  ++++ +++l  ed++
     EFC37310.1 113 WV---LTstypeVVEKliVLNVPHPvsmqreigqlplK-----TiyaqlKKSWYILFMQLGFsipenyfkndNYRALAFAYLDLAKKGILTMEDYH 200
                    88...333336665669566666445544444333231.....12222222222222233331111111122222222222223333555555533 PP

                    CCHCHCCCGHH.............................HHCCHHCHTTCCHHTT-TTGC.............EEECTT-C..........HHHH CS
  Abhydrolase_6 142 aawrarlarla.............................allaglgllpaaawadlpvpl.............lvlggeDp..........lvpr 185
                     ++  + ++ a                             +  +++g            +l             l+l+g+D+          + + 
     EFC37310.1 201 HYVKGWAQPDAldammayykgfmtgkfanaikmklgypdaRRYPKVG-----------QTLeapleqqkvkvptLILWGKDDlalieetadlSFKY 285
                    33333333333333666666555555554444444333322222222...........22233344444444769999999977555333221112 PP

                    CHHCCCHSTTEEETCE...SSS-HHH CS
  Abhydrolase_6 186 llerllaqagarlpvvlpgaGHlphl 211
                    ++++    ++ +  ++   aGH++ l
     EFC37310.1 286 YIDESVK-PKSK--IIKFEAGHFIAL 308
                    2222222.3333..555569998766 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   1.1e-06    0.0039      30     108 ..      50     130 ..      13     180 .. 0.77
   2 !    4.8   0.0    0.0042        15     186     203 ..     255     272 ..     244     295 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1.1e-06
  Hydrolase_4  30 qGfavyalDhrGhGrse.gkrghvpsfd..dyvdDlaafvekvkeehpelplfllGhSmGGliallyllrypdkvaglilsa 108
                  + fa +a D rG+  s+ +   +++++d  ++v D++ ++e   ++ +++  +l++h +G++i+  ++ +yp+ v++li+ +
   EFC37310.1  50 KRFALMAPDLRGYNTSDkPDITDLNNYDmgELVHDIKGLIEGYYKNGKGK-AVLVAHDWGAIISWVLTSTYPEVVEKLIVLN 130
                  45899************86666776665338**********999666655.89********************999999865 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0042
  Hydrolase_4 186 raakitlPllllhGeaDk 203
                  +++k+++P+l+l G++D 
   EFC37310.1 255 EQQKVKVPTLILWGKDDL 272
                  578999**********95 PP

>> FSH1  Serine hydrolase (FSH1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.47   1.7e+03       7      29 ..      19      42 ..      14      74 .. 0.72
   2 ?   11.5   0.0   4.9e-05      0.17     154     202 ..     253     306 ..     219     313 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.47
        FSH1  7 iLcLhGytqsgei.Fraktsalrk 29
                i+ LhG+ q + + + ++++++ k
  EFC37310.1 19 IIYLHGFPQAAATcWTYQLQDFAK 42
                788999999765415666666665 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 4.9e-05
        FSH1 154 yyeedkiqtptLhvlGelDtvvdee.....rseaLaeafknsskvlkHpggHfv 202
                   e++k+++ptL + G++D    ee        ++ e++k +sk++k++ gHf+
  EFC37310.1 253 PLEQQKVKVPTLILWGKDDLALIEEtadlsFKYYIDESVKPKSKIIKFEAGHFI 306
                 348999*************77664423322234444555555**********98 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0     4e-05      0.14      81     152 ..      91     158 ..      71     179 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4e-05
       PGAP1  81 slysssekeptsviliGHSmGGivaraaltlknyikqsvntiltlasPhalpplsf..dkdilklyervnefwk 152
                       ++ + + +l++H  G i++    +l +  ++ v+++++l  Ph  +  +   +  +  +y+++++ w 
  EFC37310.1  91 GY---YKNGKGKAVLVAHDWGAIIS---WVLTSTYPEVVEKLIVLNVPHPVSMQREigQLPLKTIYAQLKKSWY 158
                 33...37788899************...66777789************97665433113345667888888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       473  (0.0263818); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1972.90
//
Query:       EFC37311.1  [L=844]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.5e-10   40.7   0.0    5.6e-10   39.6   0.0    1.6  1  CHASE4       CHASE4 domain
    6.8e-10   39.3   5.6    6.8e-10   39.3   5.6    2.4  2  RGS          Regulator of G protein signaling domain
    0.00038   20.8   0.0    0.00078   19.8   0.0    1.5  1  HAMP         HAMP domain
     0.0015   18.7   0.2     0.0057   16.9   0.2    2.1  1  PAS_9        PAS domain
  ------ inclusion threshold ------
       0.02   15.4   2.6        1.3    9.7   0.1    3.2  2  s48_45       Sexual stage antigen s48/45 domain
      0.024   14.7   0.3      0.095   12.7   0.0    2.2  2  PAS          PAS fold
        5.1    7.2   8.8        8.3    6.6   3.0    2.5  2  NS3_envE     Non-structural protein NS3/Small envelope protei


Domain annotation for each model (and alignments):
>> CHASE4  CHASE4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.6   0.0   2.2e-13   5.6e-10      13     137 .]     166     329 ..     160     329 .. 0.80

  Alignments for each domain:
  == domain 1  score: 39.6 bits;  conditional E-value: 2.2e-13
      CHASE4  13 lkdwavWDdtyafvqd.rdpd.............yiesnlgdetletlgldlvlfldadgklvy.....dqengq.....................ekl 71 
                 l ++a WD+t ++  +   +d             y  +n+  + +++ +l lv+++  +g+ +      +    +                     +  
  EFC37311.1 166 LLEYAPWDSTLNLFVNvTYEDgttiepspelvdqYFTNNIFCSYMSNVNLSLVALYYLNGTKLRsmacfN----StleeslpeelenlspdhylikD-- 258
                 6789*******999996777799*******9999**************************9994334442....03333555555545555566551.. PP

      CHASE4  72 lseaeee...........sgrsgllkldggpalvaaapIltsegegpsrGtlvfgryldeallsrlseltlldlels 137
                       +           ++ s  ++  + +++++a+p+l s+ +++s G++vfgry +++ +++l   t+l+++++
  EFC37311.1 259 ------MsvtstrratymKPSSNNVNHSNDMLMLVAMPVLSSDYSSESGGVMVFGRYQNADAIHALTTKTQLCISFY 329
                 ......0333333334435999999*************************************************996 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.3       2.1   5.4e+03      61      96 ..     568     603 ..     527     610 .. 0.61
   2 !   39.3   5.6   2.6e-13   6.8e-10       4     111 ..     698     805 ..     695     807 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.1
                 TSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHH CS
         RGS  61 sspkelnidkklreelekrlekeqpsrklfeeaqee 96 
                 +  k ln + +  +++ +r+ +e + +k+ ++a +e
  EFC37311.1 568 KDGKILNYNTSFQAKIMTRVVNEATEKKVTNKAINE 603
                 333455777777777777777777777777776665 PP

  == domain 2  score: 39.3 bits;  conditional E-value: 2.6e-13
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHHHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqeevfelle 102
                 +  +++  ++ +r F+ +e+s en+ F+++ve ++k k  ++++kk +eI+ ++l ++++ elni+k+   ++ +++++   + +l++++ + v  ++ 
  EFC37311.1 698 YYWKNKEMKEKLRIFCINEKSYENCLFLEEVEAYRKIKRTHNRVKKQQEIIAKFLTKDAKYELNISKEEEFTIVSKIRDGYGQIDLLDKLFSIVRGMFY 796
                 556778889999*************************************************************************************** PP

                 HHHHHHHHT CS
         RGS 103 kdsypkFlk 111
                 +d +++Flk
  EFC37311.1 797 RDTFQRFLK 805
                 ********8 PP

>> HAMP  HAMP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.0     3e-07   0.00078       6      51 ..     473     523 ..     469     525 .. 0.85

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 3e-07
                 THHHHHHHHHHHHHHTTTBTSST.....CCTTSSSHHHHHHHHHHHHHHHH CS
        HAMP   6 ilrPLrrLaraarriaaGdldtr.....lpvsgrDEiGeLarafNaMldrL 51 
                 +lr++ rL+ ++ +i +++ ++      +p +++DEiG+La  +N Ml  L
  EFC37311.1 473 VLRRMVRLTNSVVKITNNWETVVmngsrIPKYTQDEIGRLANRVNLMLGVL 523
                 6889999999999999986666677777*******************9766 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.2   2.2e-06    0.0057       4     100 ..     563     668 ..     559     672 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 2.2e-06
       PAS_9   4 ilidnpdgrilyaNeaalrllGys.......peevlgksitdlfvtdpeanerlraaleqgrk...kerevevvlirkngetfwvlltaspvkdddgel 92 
                 i id +dg+il +N+++   +  +       ++ v +k i + f+++p  +e l ++ +   +   k +e + v +++   +++v+++ + +  d+ge+
  EFC37311.1 563 ITIDSKDGKILNYNTSFQAKIM-TrvvneatEKKVTNKAINEYFDSKPTMQELLGRMEDIC-SgtaKIWETNFVSRYNALIPIHVNCSKVKIVIDGGEI 659
                 44699*************9985.43656666888999999999933333333333333333.3677777777777777777777777777777787777 PP

       PAS_9  93 vg.iivilr 100
                 v  ++++ r
  EFC37311.1 660 VDaFVLLAR 668
                 764666665 PP

>> s48_45  Sexual stage antigen s48/45 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1    0.0005       1.3      23      85 ..     203     263 ..     188     285 .. 0.72
   2 ?    4.0   0.3     0.028        70      63     105 ..     672     714 ..     661     717 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0005
                 BCCEEEEEE-T.T-EEEEE--TT-EEESTTCTTEEEEEETTEEEEGCCCCC-T-EEE--SCTTT CS
      s48_45  23 knkeCnvkikk.ndivGlkCpkgfklePenCFenvlekkeeekvkleellkkkielekdsnkkn 85 
                 +n+ C+   +   ++v+l+  +g+kl+   CF++ l  +e+  ++le+l + ++ ++ d + ++
  EFC37311.1 203 NNIFCSYMSNVnLSLVALYYLNGTKLRSMACFNSTL--EESLPEELENLSPDHYLIK-DMSVTS 263
                 6778887777657899********************..999999*****99333333.322222 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.028
                 EEEEGCCCCC-T-EEE--SCTTTTEEEEE--SCE-S-EEEEEE CS
      s48_45  63 ekvkleellkkkielekdsnkknttsylklpkkikesvkfsCs 105
                 ++++l++ +k++ e  ++++ ++++ y + +k++ke++ ++C 
  EFC37311.1 672 DQYELQKTIKTQQEQFSEQRMNFEFDYYWKNKEMKEKLRIFCI 714
                 567899999999999999***********9999*********6 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   3.7e-05     0.095       2      31 ..     550     580 ..     549     651 .. 0.86
   2 ?   -2.3   0.0       1.7   4.4e+03      53      78 ..     671     693 ..     664     714 .. 0.65

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.7e-05
                 HHHHHHHHSSSEEEEEE.TTSBEEEECHHHH CS
         PAS   2 dlraileslpdpifvvD.edgrilyvNaaae 31 
                 ++r++l+++ d+i+ +D +dg+il  N++++
  EFC37311.1 550 KYRQVLNAISDFIITIDsKDGKILNYNTSFQ 580
                 79**************************997 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.7
                 THHHHHHHHHHHHHHHTT-ECCCCEE CS
         PAS  53 eddaelaelleqlleqgeesrageis 78 
                  d++el++ ++++ eq +e+r+   +
  EFC37311.1 671 ADQYELQKTIKTQQEQFSEQRM---N 693
                 4544566666666666655554...4 PP

>> NS3_envE  Non-structural protein NS3/Small envelope protein E
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.3     0.032        82      17      50 ..     107     139 ..      96     171 .. 0.67
   2 ?    6.6   3.0    0.0032       8.3      15      42 ..     448     475 ..     439     490 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.032
    NS3_envE  17 filvvlivvlliviallkvikLClvlcglcntlv 50 
                 f   + i++ll+ +++l+ + + +v   l+ t v
  EFC37311.1 107 FK-TLTILLLLFFVTVLACLVILIVAFHLSYTRV 139
                 44.3456677777888887777777776666555 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0032
    NS3_envE  15 vlfilvvlivvlliviallkvikLClvl 42 
                 ++ + v+ ++++++++a+++ i L +  
  EFC37311.1 448 LITWGVMTVMLIILSVAVMAFIELVVLR 475
                 578999*****************98754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (844 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2022  (0.112778); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.82u 0.29s 00:00:01.10 Elapsed: 00:00:00.50
# Mc/sec: 5037.93
//
Query:       EFC37312.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.1e-07   29.0   7.9       0.24   11.6   0.1    5.2  4  LRR_6     Leucine Rich repeat
    0.00017   21.9  19.2       0.22   12.0   1.5    6.1  6  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   0.1   2.6e-05      0.24       3      24 .]     120     141 ..     118     141 .. 0.93
   2 ?   -0.4   0.2      0.18   1.6e+03       1       8 [.     223     230 ..     223     231 .. 0.89
   3 !    7.7   0.0   0.00047       4.2       4      24 .]     256     276 ..     253     276 .. 0.89
   4 !   10.1   0.2   7.8e-05       0.7       2      23 ..     281     302 ..     280     303 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.6e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt+LdL   +IgD+G +aLa
  EFC37312.1 120 KNLTYLDLDRVNIGDDGFKALA 141
                 58******************98 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.18
       LRR_6   1 snthLteL 8  
                 +nt+Lt+L
  EFC37312.1 223 HNTYLTKL 230
                 8*****99 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.00047
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 ++t L L + ++gDeG++ +a
  EFC37312.1 256 NITDLYLDYAELGDEGMKVIA 276
                 789999************987 PP

  == domain 4  score: 10.1 bits;  conditional E-value: 7.8e-05
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  t+L+eL+++  +I+++Ga  L
  EFC37312.1 281 MTNLKELSIANANISNVGALYL 302
                 689***************9866 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.1      0.02   1.8e+02      21      37 ..      90     111 ..      81     115 .. 0.65
   2 !   11.4   1.3   3.8e-05      0.34       2      33 ..      94     130 ..      93     169 .. 0.85
   3 ?    2.9   0.1     0.018   1.6e+02      17      35 ..     168     185 ..     160     194 .. 0.76
   4 ?    2.8   0.5      0.02   1.8e+02       2      30 ..     203     235 ..     195     269 .. 0.66
   5 !   10.6   0.3   6.8e-05      0.61      16      40 ..     275     298 ..     255     303 .. 0.69
   6 !   12.0   1.5   2.5e-05      0.22       1      28 [.     282     314 ..     282     319 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.02
                 H.-TT--EEE-.-S....---- CS
       LRR_4  21 k.lpnLkeLdLsgN....nlit 37 
                 k l nL++L+++g     n+i+
  EFC37312.1  90 KyLINLRSLSVHGRdetvNKID 111
                 4499******955334445554 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 3.8e-05
                 S--EEE--S.....S---E-S-HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsn.....NqltdiplleklpnLkeLdLsgN 33 
                 nL++L+ ++     N++ ++   + l+nL++LdL + 
  EFC37312.1  94 NLRSLSVHGrdetvNKIDKLFKGKTLKNLTYLDLDRV 130
                 8999999976788899999555446*********774 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.018
                 S-HHH-TT--EEE-.-S-- CS
       LRR_4  17 plleklpnLkeLdLsgNnl 35 
                 +  e++ +L+ +d+ +N++
  EFC37312.1 168 SESENFSKLTFIDI-SNTQ 185
                 45567999999999.5544 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.02
                 S--EEE--SS-....--E-S-HHH.-TT--EEE- CS
       LRR_4   2 nLevLdLsnNq....ltdipllek.lpnLkeLdL 30 
                 nL+++++sn      l d+   +  l++L+ +++
  EFC37312.1 203 NLKSISFSN-EaddtLMDLLTHNTyLTKLERIYM 235
                 344444442.333333333223333777777777 PP

  == domain 5  score: 10.6 bits;  conditional E-value: 6.8e-05
                 -S-.HHH-TT--EEE-.-S-----GG CS
       LRR_4  16 ipl.leklpnLkeLdLsgNnlitdld 40 
                 i   + +++nLkeL++  N +i+++ 
  EFC37312.1 275 IAEcP-NMTNLKELSI-ANANISNVG 298
                 33434.5*********.665687775 PP

  == domain 6  score: 12.0 bits;  conditional E-value: 2.5e-05
                 SS--EEE--SS---E-S-HH....H.-TT--EE CS
       LRR_4   1 pnLevLdLsnNqltdiplle....k.lpnLkeL 28 
                 +nL++L+++n +++ ++ l+    k l+nL++L
  EFC37312.1 282 TNLKELSIANANISNVGALYllesKyLKNLTSL 314
                 7*****************66667977****999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       448  (0.0249875); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1921.31
//
Query:       EFC37313.1  [L=486]
Description: hypothetical protein NAEGRDRAFT_74906 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0018   18.1   0.0     0.0049   16.7   0.0    1.8  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.048   13.6   1.5       0.52   10.3   0.0    3.3  3  F-box       F-box domain
       0.52   10.1  13.0        5.9    6.7   0.0    4.7  5  LRR_8       Leucine rich repeat


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   8.2e-07    0.0049       6      34 ..      30      60 ..      25      63 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 8.2e-07
  F-box-like  6 dEiLlqIFsyL.ppsdLlr.lalVCrrWrrv 34
                +EiL  IF +L p +dLl+ +++VC ++ ++
  EFC37313.1 30 NEILANIFLFLdPITDLLPnVMAVCEKFFEI 60
                9**********6677***99*****998776 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   8.7e-05      0.52       5      33 ..      27      57 ..      24      64 .. 0.88
   2 ?   -1.0   0.0       0.3   1.8e+03       5      15 ..     308     318 ..     306     323 .. 0.83
   3 ?   -1.4   0.2       0.4   2.4e+03       9      24 ..     341     356 ..     337     356 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 8.7e-05
                HS-HHHHHHHHHTS-HHH..HHHHCTT-HHH CS
       F-box  5 rLPsevlrhILerLplsd..llalrrVSkgw 33
                 L +e+l +I+ +L++++  l + + V+ ++
  EFC37313.1 27 HLTNEILANIFLFLDPITdlLPNVMAVCEKF 57
                6889************************988 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.3
                 HS-HHHHHHHH CS
       F-box   5 rLPsevlrhIL 15 
                 +L ++++rhI 
  EFC37313.1 308 ELDLDIIRHIV 318
                 67899****97 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.4
                 HHHHHHHHTS-HHHHH CS
       F-box   9 evlrhILerLplsdll 24 
                 evl++ Le ++ s++l
  EFC37313.1 341 EVLEETLELVDDSYVL 356
                 89*******9999876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       1.3   7.9e+03      28      35 ..     112     119 ..     111     120 .. 0.80
   2 ?    5.4   2.1    0.0026        15      19      58 ..     142     186 ..     128     187 .. 0.72
   3 ?    5.0   0.6    0.0034        21      18      34 ..     170     186 ..     162     207 .. 0.72
   4 ?    6.7   0.0   0.00098       5.9       3      36 ..     224     257 ..     223     259 .. 0.92
   5 ?    1.0   0.3      0.06   3.6e+02      38      57 ..     390     408 ..     385     425 .. 0.67

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.3
                 -EEE--SS CS
       LRR_8  28 kvLdLsnN 35 
                 kvL+L+nN
  EFC37313.1 112 KVLKLGNN 119
                 68899998 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0026
                 TSSTT-TT--EEE--......SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8  19 eaFkglsnLkvLdLs......nNllttlspgafsgLpsLrsLdLsg 58 
                 ++F+gl++L  +++s      + +++ l +++ s+L++L++L+L++
  EFC37313.1 142 GCFNGLKKLSLFNISifkqmsQKNIKIL-KEWVSSLSNLEELHLNN 186
                 6677777777777643333325567788.68888888888888875 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0034
                 TTSSTT-TT--EEE--S CS
       LRR_8  18 deaFkglsnLkvLdLsn 34 
                 +e+ ++lsnL++L+L+n
  EFC37313.1 170 KEWVSSLSNLEELHLNN 186
                 45666666666666653 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.00098
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNl 36 
                 L+sLd+s +  ++++ ++F++ ++Lk L ++ N 
  EFC37313.1 224 LESLDISTSDDNDINYSFFTRTPHLKKLAIGFNY 257
                 89999999999******************99985 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.06
                 -GGGGGGGTT--S-.EEE-- CS
       LRR_8  38 ttlspgafsgLpsLrsLdLs 57 
                  t+  + f+ Lp L +L L+
  EFC37313.1 390 VTI-GDLFEELPLLNELLLT 408
                 445.3667777777777664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       619  (0.0345251); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2770.80
//
Query:       EFC37314.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1124  (0.0626917); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.25s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 2441.05
//
Query:       EFC37315.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0011   18.7   0.7     0.0011   18.6   0.7    1.1  1  SUR7             SUR7/PalI family
  ------ inclusion threshold ------
       0.13   12.9   1.9       0.18   12.4   1.9    1.2  1  Pex14_N          Peroxisomal membrane anchor protein (Pex14p)
       0.16   10.1   3.7       0.18    9.9   3.7    1.0  1  Glucan_synthase  1,3-beta-glucan synthase component
        1.8    9.1   9.3        2.4    8.7   9.3    1.1  1  FtsX             FtsX-like permease family


Domain annotation for each model (and alignments):
>> SUR7  SUR7/PalI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.7   2.5e-07    0.0011      97     175 ..      60     143 ..       5     148 .. 0.66

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 2.5e-07
        SUR7  97 lPsnlrktlsklnnltkalfilhiialvlsfislvv..gllaic...vspdnsr...llsflnlllsvlsflatllaalldtllfvf 175
                 +P ++ ++     ++ +++ ++ i  +++ ++++     l+ ++       +s+     +   ++l+++++l++ + ++++t+++v 
  EFC37315.1  60 VPVDIDQDAAEASSAFTMAICFSILMTCFGCVCMSSipFLFVWVmyrK---SSSeraKRLSSLSMLTFFILLCMNIVFIIITICVVT 143
                 666666666666666677777777777777774444225555555441...333222245556699999999999999999999995 PP

>> Pex14_N  Peroxisomal membrane anchor protein (Pex14p) conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.9     4e-05      0.18      67     143 ..       7      86 ..       1      96 [. 0.45

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 4e-05
     Pex14_N  67 qeesasssatpqpqaasqtsqsspspsppaqqqqqqyrpPivtypefltk...ppkppppPlrtwrdllitatalaglga 143
                 ++++++++ +p+++ + +++q+ ++++++++q+ ++ + Pi  +p+++++    p +  +   + ++++++a  ++ l++
  EFC37315.1   7 TTQPQQQAINPSEPVPVSHEQKYETKPSHTGQSVHYVHDPIYVQPQYQQPvmmVPVDIDQDAAEASSAFTMAICFSILMT 86 
                 22233333333333333333333333344444444445555555544443221222223334477888888887777765 PP

>> Glucan_synthase  1,3-beta-glucan synthase component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   3.7     4e-05      0.18     741     816 ..      70     146 ..      47     149 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 4e-05
  Glucan_synthase 741 dvkrasllnlllseiile.llvvlllliaylfinsqtgvkeaeatnsvlrlaivsllp.illnvvvllvlfalslllg 816
                      +++ ++++  ++ +i+++ + +v+++ i++lf+ + +  +++e+++ +  l +++++  +++n+v++++++++++++ 
       EFC37315.1  70 EAS-SAFTMAICFSILMTcFGCVCMSSIPFLFVWVMYRKSSSERAKRLSSLSMLTFFIlLCMNIVFIIITICVVTIVP 146
                      233.33444444445544055677889*************************99876615677777777777776665 PP

>> FtsX  FtsX-like permease family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   9.3   0.00053       2.4      17      86 ..      74     145 ..      69     151 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00053
        FtsX  17 vlllllteillitlvalviGlglgllaaqllsdvllssvfs..selkisidlitvliiivlllllallagll 86 
                  + + +  ++l t++++v    + +l+ ++++ + +s+  +  s+l++ + +i ++  iv++++++ +++++
  EFC37315.1  74 AFTMAICFSILMTCFGCVCMSSIPFLFVWVMYRKSSSERAKrlSSLSMLTFFILLCMNIVFIIITICVVTIV 145
                 577889999**************************9996657766666666666666666666655555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1345  (0.0750181); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.34s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 870.33
//
Query:       EFC37316.1  [L=267]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00023   20.5   0.0    0.00044   19.6   0.0    1.4  1  Hydrolase_4  Serine aminopeptidase, S33
  ------ inclusion threshold ------
      0.098   12.4   0.0       0.18   11.5   0.0    1.3  1  PGAP1        PGAP1-like protein


Domain annotation for each model (and alignments):
>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   4.9e-08   0.00044      73     213 ..      62     223 ..      50     232 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 4.9e-08
  Hydrolase_4  73 hpelplfllGhSmGGliallyl....lrypd......kvaglilsaPalkikakl..............k.appllklllkllgkllpklqvsnnlka 145
                  ++e+++++lG+S  G ia++++        +       ++glil++++++ + ++              +  +   +l+  l+  l+++    +++ +
   EFC37316.1  62 EEETNVVILGESFSGPIATSITsmmnN---EreggefPISGLILCCTFVANPRPVlsfpfrfifsspnsNnQSFKTNLMDSLIRILFQQEW-LMKIIS 155
                  456699**************9976431...1356888999*********999888777777777544432122222223333333333333.477777 PP

  Hydrolase_4 146 dslsrdpevvaayeadplvhgkitvrlllelldamkrleeraakitlPllllhGeaDkvvdpeasrel 213
                  + + + ++++ ++ +   ++    ++l l  +  ++r+ee  +  ++Pll+l + +D++v+++a++ l
   EFC37316.1 156 KLMFHSEKQRNLFLRAMKITPPEVIGLRLRNVLYVNRIEELRKCNNIPLLILRARNDWIVPNSAQQLL 223
                  7777888888877777777777777888888888999999999999***************9999654 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0     2e-05      0.18      71     113 ..      47      87 ..      40      93 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2e-05
       PGAP1  71 ylndaIkyIlslysssekeptsviliGHSmGGivaraaltlkn 113
                 y    Ik+Il+ y  + +e+t+v+++G S+ G +a +++ + n
  EFC37316.1  47 YSRRKIKEILDNY--HMEEETNVVILGESFSGPIATSITSMMN 87 
                 556789*******..9999****************99887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1715.62
//
Query:       EFC37317.1  [L=651]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      7e-35  117.4  10.2    0.00029   20.5   0.0    9.5  9  TPR_1       Tetratricopeptide repeat
    1.6e-24   84.0   8.3     0.0018   18.2   0.0   10.0  9  TPR_2       Tetratricopeptide repeat
    1.4e-20   71.7  14.2       0.26   11.6   0.3    9.5  9  TPR_8       Tetratricopeptide repeat
    3.1e-20   71.6  10.8    0.00011   21.8   0.1    7.9  9  TPR_11      TPR repeat
    1.1e-19   69.3   4.9     0.0008   19.6   0.1    7.2  7  TPR_17      Tetratricopeptide repeat
    1.2e-14   54.2   0.0    0.00019   21.5   0.0    4.9  5  TPR_9       Tetratricopeptide repeat
    5.9e-13   48.9   4.0      0.083   13.2   0.0    6.5  5  TPR_12      Tetratricopeptide repeat
    3.1e-12   46.2   0.3     0.0095   16.7   0.1    6.2  6  TPR_14      Tetratricopeptide repeat
    2.3e-10   40.9   3.3    2.3e-05   24.9   0.0    5.1  6  TPR_16      Tetratricopeptide repeat
    9.7e-10   38.5   4.9      0.025   15.2   0.0    7.1  8  TPR_6       Tetratricopeptide repeat
    5.9e-07   29.9   6.2      0.024   15.2   0.0    5.6  5  TPR_19      Tetratricopeptide repeat
    0.00011   22.0   0.2        9.4    6.5   0.0    6.0  6  TPR_7       Tetratricopeptide repeat
     0.0055   16.9   1.9       0.51   10.6   0.0    3.5  3  ANAPC3      Anaphase-promoting complex, cyclosome, subunit 3
      0.006   16.9   3.6        1.2    9.5   0.0    3.2  2  TPR_20      Tetratricopeptide repeat
     0.0065   16.5   6.8          1    9.4   0.0    4.3  4  Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
  ------ inclusion threshold ------
      0.029   14.4   1.8        2.4    8.3   0.0    3.8  5  DUF357      Protein of unknown function (DUF357)
        3.3    7.8   5.6        2.8    8.1   0.1    3.4  4  PTS_IIA     PTS system, Lactose/Cellobiose specific IIA subun


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   2.8e-07   0.00029       4      34 .]     234     264 ..     231     264 .. 0.92
   2 !    9.5   0.0   0.00086       0.9       4      33 ..     268     297 ..     265     298 .. 0.88
   3 !   16.5   0.0   5.3e-06    0.0055       2      32 ..     300     330 ..     300     332 .. 0.90
   4 !   18.0   0.1   1.8e-06    0.0018       2      34 .]     334     366 ..     333     366 .. 0.94
   5 !   12.8   0.0   7.5e-05     0.079      15      34 .]     398     417 ..     391     417 .. 0.90
   6 !    9.1   0.1    0.0011       1.2      11      29 ..     429     447 ..     419     451 .. 0.92
   7 !    8.4   0.0    0.0018       1.9       5      30 ..     519     544 ..     516     546 .. 0.90
   8 ?    3.7   0.2     0.055        58       1      12 [.     562     573 ..     562     575 .. 0.89
   9 !   15.4   0.3   1.2e-05     0.012      18      34 .]     580     596 ..     578     596 .. 0.93

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 2.8e-07
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   4 lynlGnayfklgkydeAleyyekALelnPnn 34 
                 l ++++ ++klg +d+Ale ++kA+e+ P++
  EFC37317.1 234 LTRKALGLHKLGALDKALETCDKAIEIMPDF 264
                 7899999********************9996 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00086
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   4 lynlGnayfklgkydeAleyyekALelnPn 33 
                 +  ++ +++ ++k++e +e+++k L++++ 
  EFC37317.1 268 YLVRASTFLFMEKPQESIEACNKTLSIEEG 297
                 777899999****************99876 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 5.3e-06
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHST CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnP 32 
                 +a+  +++ y+klg+ ++Al + +  Le  P
  EFC37317.1 300 EAYLCRAVSYLKLGDTEKALTDLNTLLEAHP 330
                 69********************998888766 PP

  == domain 4  score: 18.0 bits;  conditional E-value: 1.8e-06
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                 +al  ++++yf++++yd A+ + e+A+  n n+
  EFC37317.1 334 DALTKRAAIYFSKKMYDSAILDVERAIYYNSND 366
                 7999***********************999886 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 7.5e-05
                 T-HHHHHHHHHHHHHHSTTH CS
       TPR_1  15 gkydeAleyyekALelnPnn 34 
                 ++  +A++++++A+++nP++
  EFC37317.1 398 NQIADAVKAFDEAIKVNPDD 417
                 7899**************96 PP

  == domain 6  score: 9.1 bits;  conditional E-value: 0.0011
                 HHHTT-HHHHHHHHHHHHH CS
       TPR_1  11 yfklgkydeAleyyekALe 29 
                 y ++g+ + Ale+ ++A+ 
  EFC37317.1 429 YNYMGDSKAALEDLQQAID 447
                 899**************96 PP

  == domain 7  score: 8.4 bits;  conditional E-value: 0.0018
                 HHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekALel 30 
                   +G ++  +++ ++ +e + kA+e+
  EFC37317.1 519 TSMGSIHILMNENEQGIELFTKAIEV 544
                 679*********************97 PP

  == domain 8  score: 3.7 bits;  conditional E-value: 0.055
                 HHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayf 12 
                 a a++n++++y+
  EFC37317.1 562 AAAYFNRAHVYH 573
                 78*********7 PP

  == domain 9  score: 15.4 bits;  conditional E-value: 1.2e-05
                 HHHHHHHHHHHHHSTTH CS
       TPR_1  18 deAleyyekALelnPnn 34 
                 + Al++y+ A++lnPnn
  EFC37317.1 580 ELALKDYDMAIKLNPNN 596
                 78**************8 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0   2.8e-05      0.03       3      33 ..     233     263 ..     231     264 .. 0.91
   2 ?    1.4   0.0      0.42   4.4e+02      11      34 .]     275     298 ..     267     298 .. 0.79
   3 !   18.2   0.0   1.7e-06    0.0018       2      32 ..     300     330 ..     299     332 .. 0.94
   4 !   11.7   0.1   0.00021      0.22       2      34 .]     334     366 ..     333     366 .. 0.92
   5 !   11.0   0.0   0.00035      0.37      15      34 .]     398     417 ..     391     417 .. 0.91
   6 ?    3.2   0.1      0.12   1.2e+02      13      29 ..     431     447 ..     420     450 .. 0.79
   7 ?    4.1   0.0     0.057        60       7      30 ..     521     544 ..     516     547 .. 0.89
   8 !    8.7   0.9    0.0019         2      17      34 .]     579     596 ..     562     596 .. 0.76
   9 ?    3.2   0.0      0.11   1.2e+02       2      22 ..     598     618 ..     597     625 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 2.8e-05
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPn 33 
                 +l + +l + klg +++Ale ++kA+e+ P+
  EFC37317.1 233 LLTRKALGLHKLGALDKALETCDKAIEIMPD 263
                 57789999**********************8 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.42
       TPR_2  11 yyklgdyeeAleafekAleldPnn 34 
                  + + +++e +ea++k l+++++n
  EFC37317.1 275 FLFMEKPQESIEACNKTLSIEEGN 298
                 5667899**********9998765 PP

  == domain 3  score: 18.2 bits;  conditional E-value: 1.7e-06
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldP 32 
                 ea+ +++ +y+klgd e+Al +++  le  P
  EFC37317.1 300 EAYLCRAVSYLKLGDTEKALTDLNTLLEAHP 330
                 79*************************9888 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 0.00021
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                 +al  ++ +y+ ++ y+ A+ + e+A+ ++ n+
  EFC37317.1 334 DALTKRAAIYFSKKMYDSAILDVERAIYYNSND 366
                 68999**********************999875 PP

  == domain 5  score: 11.0 bits;  conditional E-value: 0.00035
       TPR_2  15 gdyeeAleafekAleldPnn 34 
                 ++ ++A++af++A++ +P++
  EFC37317.1 398 NQIADAVKAFDEAIKVNPDD 417
                 6889**************97 PP

  == domain 6  score: 3.2 bits;  conditional E-value: 0.12
       TPR_2  13 klgdyeeAleafekAle 29 
                 ++gd + Ale++++A+ 
  EFC37317.1 431 YMGDSKAALEDLQQAID 447
                 46777888888888875 PP

  == domain 7  score: 4.1 bits;  conditional E-value: 0.057
       TPR_2   7 lGlayyklgdyeeAleafekAlel 30 
                 +G +++ +++ e+ +e+f kA+e 
  EFC37317.1 521 MGSIHILMNENEQGIELFTKAIEV 544
                 689999****************96 PP

  == domain 8  score: 8.7 bits;  conditional E-value: 0.0019
       TPR_2  17 yeeAleafekAleldPnn 34 
                  e Al++++ A++l+Pnn
  EFC37317.1 579 NELALKDYDMAIKLNPNN 596
                 388**************8 PP

  == domain 9  score: 3.2 bits;  conditional E-value: 0.11
       TPR_2   2 ealynlGlayyklgdyeeAle 22 
                   ++++ ++++++g+ e A++
  EFC37317.1 598 LFYHYRSMLHIHMGNDELAKK 618
                 579**************9998 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0    0.0045       4.7      11      33 ..     241     263 ..     233     264 .. 0.85
   2 !    7.5   0.0    0.0052       5.5       2      32 ..     266     296 ..     265     298 .. 0.92
   3 !    8.7   0.0    0.0021       2.2       3      30 ..     301     328 ..     300     331 .. 0.84
   4 !   11.6   0.3   0.00024      0.26       2      33 ..     334     365 ..     333     366 .. 0.92
   5 !    7.2   0.0    0.0065       6.9      13      34 .]     396     417 ..     390     417 .. 0.85
   6 !    7.4   0.2    0.0055       5.8       3      28 ..     420     446 ..     418     447 .. 0.87
   7 !    9.8   0.0   0.00093      0.98       3      31 ..     517     545 ..     515     547 .. 0.89
   8 !   11.0   0.3   0.00038       0.4       1      34 []     562     596 ..     562     596 .. 0.96
   9 ?    0.3   0.0         1   1.1e+03       7      22 ..     603     618 ..     599     627 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0045
                 HHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8  11 ylklgdyeeAkeyyekaleldpd 33 
                 ++klg +++A e++ ka+e+ pd
  EFC37317.1 241 LHKLGALDKALETCDKAIEIMPD 263
                 789****************9765 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0052
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleldp 32 
                 ++y+  +s+ l +++ +e++e+++k l++++
  EFC37317.1 266 PSYLVRASTFLFMEKPQESIEACNKTLSIEE 296
                 7899*********************999976 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0021
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekalel 30 
                 ay+  +  ylklgd e+A   ++  le+
  EFC37317.1 301 AYLCRAVSYLKLGDTEKALTDLNTLLEA 328
                 55667889*************9999986 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 0.00024
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 +a+ + + iy++++ y++A+   e+a++++ +
  EFC37317.1 334 DALTKRAAIYFSKKMYDSAILDVERAIYYNSN 365
                 57889999********************9987 PP

  == domain 5  score: 7.2 bits;  conditional E-value: 0.0065
                 HTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8  13 klgdyeeAkeyyekaleldpdn 34 
                 + +++  A++++ +a++ +pd+
  EFC37317.1 396 TRNQIADAVKAFDEAIKVNPDD 417
                 5678899*************96 PP

  == domain 6  score: 7.4 bits;  conditional E-value: 0.0055
                 HHHHHHHHH.HHTT-HHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiy.lklgdyeeAkeyyekal 28 
                 +y++ g++    +gd ++A e +++a+
  EFC37317.1 420 SYHQRGLLQyNYMGDSKAALEDLQQAI 446
                 6888897766****************9 PP

  == domain 7  score: 9.8 bits;  conditional E-value: 0.00093
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleld 31 
                 a   +gsi++ +++ e+ +e + ka+e +
  EFC37317.1 517 AITSMGSIHILMNENEQGIELFTKAIEVA 545
                 56679*********************987 PP

  == domain 8  score: 11.0 bits;  conditional E-value: 0.00038
                 CCHHHHHHHHH.HHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   1 aeayynlgsiy.lklgdyeeAkeyyekaleldpdn 34 
                 a ay+n +++y +k  + e A + y  a++l+p+n
  EFC37317.1 562 AAAYFNRAHVYhMKIINNELALKDYDMAIKLNPNN 596
                 579******************************97 PP

  == domain 9  score: 0.3 bits;  conditional E-value: 1
                 HHHHHHHTT-HHHHHH CS
       TPR_8   7 lgsiylklgdyeeAke 22 
                  +++++ +g+ e Ak+
  EFC37317.1 603 RSMLHIHMGNDELAKK 618
                 578999********98 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0    0.0049       5.1       4      27 ..     241     264 ..     240     270 .. 0.92
   2 ?    4.9   0.0      0.02        21      12      42 .]     283     313 ..     282     313 .. 0.88
   3 !   14.6   0.0   1.9e-05      0.02       4      40 ..     309     345 ..     306     347 .. 0.95
   4 ?    3.2   0.1     0.065        69       3      30 ..     342     369 ..     340     371 .. 0.91
   5 !   21.8   0.1     1e-07   0.00011       7      39 ..     397     429 ..     396     431 .. 0.95
   6 ?    4.7   0.4     0.023        25       4      23 ..     429     448 ..     428     452 .. 0.85
   7 ?   -2.2   0.0       3.2   3.4e+03       1      22 [.     522     543 ..     522     546 .. 0.81
   8 ?    5.4   0.0     0.014        14      23      40 ..     557     574 ..     556     575 .. 0.85
   9 !   17.4   0.3   2.5e-06    0.0026      10      32 ..     579     601 ..     578     604 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0049
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdn 27 
                 ++++G +++A+e   kA+++ Pd+
  EFC37317.1 241 LHKLGALDKALETCDKAIEIMPDF 264
                 5799****************9995 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.02
      TPR_11  12 eAieaYkkAlkldPdnaeayynLGlayykqG 42 
                 e+iea +k l + + n eay+++++ y+k+G
  EFC37317.1 283 ESIEACNKTLSIEEGNMEAYLCRAVSYLKLG 313
                 667777888999999**************99 PP

  == domain 3  score: 14.6 bits;  conditional E-value: 1.9e-05
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40 
                 y ++G+ e+A++++++ l+  P+  +a+ +++++y+ 
  EFC37317.1 309 YLKLGDTEKALTDLNTLLEAHPSRFDALTKRAAIYFS 345
                 999********************************96 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.065
      TPR_11   3 ayyeqGkyeeAieaYkkAlkldPdnaea 30 
                 +y+++  y+ Ai + ++A+ ++++++ +
  EFC37317.1 342 IYFSKKMYDSAILDVERAIYYNSNDVQV 369
                 8********************9999876 PP

  == domain 5  score: 21.8 bits;  conditional E-value: 1e-07
      TPR_11   7 qGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 ++++ +A++a+ +A+k +Pd+a  y+ +Gl++y
  EFC37317.1 397 RNQIADAVKAFDEAIKVNPDDAVSYHQRGLLQY 429
                 699****************************99 PP

  == domain 6  score: 4.7 bits;  conditional E-value: 0.023
      TPR_11   4 yyeqGkyeeAieaYkkAlkl 23 
                 y   G+ ++A+e++++A++ 
  EFC37317.1 429 YNYMGDSKAALEDLQQAIDK 448
                 67789999**********86 PP

  == domain 7  score: -2.2 bits;  conditional E-value: 3.2
      TPR_11   1 GdayyeqGkyeeAieaYkkAlk 22 
                 G +    +++e+ ie + kA++
  EFC37317.1 522 GSIHILMNENEQGIELFTKAIE 543
                 5566678899999999999998 PP

  == domain 8  score: 5.4 bits;  conditional E-value: 0.014
      TPR_11  23 ldPdnaeayynLGlayyk 40 
                 l+++ a ay+n++++y++
  EFC37317.1 557 LRSEMAAAYFNRAHVYHM 574
                 6777899*********97 PP

  == domain 9  score: 17.4 bits;  conditional E-value: 2.5e-06
      TPR_11  10 yeeAieaYkkAlkldPdnaeayy 32 
                 +e A+++Y  A+kl+P+n+ +y+
  EFC37317.1 579 NELALKDYDMAIKLNPNNPLFYH 601
                 688******************97 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0    0.0016       1.7       2      33 ..     254     285 ..     253     286 .. 0.91
   2 !   11.1   0.0    0.0004      0.42       2      33 ..     288     319 ..     287     320 .. 0.91
   3 ?    5.9   0.0     0.018        19       4      32 ..     324     352 ..     322     353 .. 0.90
   4 ?   -2.2   0.0       7.3   7.7e+03       3      16 ..     357     370 ..     357     371 .. 0.82
   5 !   19.6   0.1   7.6e-07    0.0008       2      33 ..     407     439 ..     406     446 .. 0.85
   6 ?    5.2   0.1     0.032        33      14      33 ..     563     590 ..     562     591 .. 0.87
   7 !   15.8   0.1   1.3e-05     0.014       2      33 ..     586     617 ..     585     618 .. 0.92

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0016
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlmtAr 33 
                 + ka+e+ P+ +++y  +A ++l   ++++ +
  EFC37317.1 254 CDKAIEIMPDFSPSYLVRASTFLFMEKPQESI 285
                 89*********************999998866 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.0004
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlmtAr 33 
                 + k l ++  n +ay  +A+ +lk+Gd+++A+
  EFC37317.1 288 CNKTLSIEEGNMEAYLCRAVSYLKLGDTEKAL 319
                 67888899999******************996 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.018
      TPR_17   4 kaleldPnnadaynnLAelllknGdlmtA 32 
                   le +P+ +da++ +A ++ +++ ++ A
  EFC37317.1 324 TLLEAHPSRFDALTKRAAIYFSKKMYDSA 352
                 579*****************999999887 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 7.3
      TPR_17   3 lkaleldPnnaday 16 
                 ++a+ ++ n++ ++
  EFC37317.1 357 ERAIYYNSNDVQVF 370
                 68999999999875 PP

  == domain 5  score: 19.6 bits;  conditional E-value: 7.6e-07
      TPR_17   2 ylkaleldPnnadaynnLAelll.knGdlmtAr 33 
                 + +a++ +P++a++y++++ l++   Gd++ A+
  EFC37317.1 407 FDEAIKVNPDDAVSYHQRGLLQYnYMGDSKAAL 439
                 889******************874558888876 PP

  == domain 6  score: 5.2 bits;  conditional E-value: 0.032
      TPR_17  14 daynnLAelll........knGdlmtAr 33 
                  ay+n+A +++         ++d+++A+
  EFC37317.1 563 AAYFNRAHVYHmkiinnelALKDYDMAI 590
                 69*********99998888888999997 PP

  == domain 7  score: 15.8 bits;  conditional E-value: 1.3e-05
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlmtAr 33 
                 y  a++l+Pnn+ +y+++  l+ + G+ + A+
  EFC37317.1 586 YDMAIKLNPNNPLFYHYRSMLHIHMGNDELAK 617
                 7789**********************999887 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.9     2e+03      36      62 ..     238     264 ..     233     273 .. 0.71
   2 !   15.7   0.0   1.2e-05     0.012      15      69 ..     285     339 ..     278     342 .. 0.85
   3 ?    1.5   0.0      0.31   3.2e+02       3      30 ..     341     368 ..     339     373 .. 0.89
   4 !   21.5   0.0   1.8e-07   0.00019       8      58 ..     397     448 ..     395     455 .. 0.93
   5 !    8.7   0.0    0.0018       1.9      11      51 ..     579     619 ..     570     637 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.9
       TPR_9  36 GlllaqlGclsaAladLeaylalapda 62 
                 +l l++lG+l +Al+  + ++++ pd 
  EFC37317.1 238 ALGLHKLGALDKALETCDKAIEIMPDF 264
                 566778888888888888777777765 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 1.2e-05
       TPR_9  15 lavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaeair 69 
                 +++++  l +     e ++ R++ + +lG++++Al dL++ l+  p++ da + r
  EFC37317.1 285 IEACNKTLSIEEGNMEAYLCRAVSYLKLGDTEKALTDLNTLLEAHPSRFDALTKR 339
                 67777788888888899999**************************999987655 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.31
       TPR_9   3 aiaireedweralavverllllaPddpe 30 
                 ai+ +++ ++ a+  ver ++ +++d++
  EFC37317.1 341 AIYFSKKMYDSAILDVERAIYYNSNDVQ 368
                 78999999****************9986 PP

  == domain 4  score: 21.5 bits;  conditional E-value: 1.8e-07
       TPR_9   8 eedweralavverllllaPddpeerrdRGlllaq.lGclsaAladLeaylal 58 
                 +++ + a ++ +  + ++Pdd+  +  RGll++  +G+ +aAl+dL++++++
  EFC37317.1 397 RNQIADAVKAFDEAIKVNPDDAVSYHQRGLLQYNyMGDSKAALEDLQQAIDK 448
                 678999*************************99879*************987 PP

  == domain 5  score: 8.7 bits;  conditional E-value: 0.0018
       TPR_9  11 weralavverllllaPddpeerrdRGlllaqlGclsaAlad 51 
                 +e al+ +++ + l+P+ p  +  R +l+ ++G+ + A +d
  EFC37317.1 579 NELALKDYDMAIKLNPNNPLFYHYRSMLHIHMGNDELAKKD 619
                 789*******************************9999877 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.0   0.00051      0.53       5      33 ..     233     261 ..     230     294 .. 0.73
   2 !   10.1   0.0   0.00075      0.79       4      31 ..     300     327 ..     263     331 .. 0.60
   3 !   12.0   0.2   0.00018      0.19       4      71 ..     300     359 ..     297     361 .. 0.79
   4 !   13.2   0.0   7.8e-05     0.083      22      73 ..     403     447 ..     390     451 .. 0.76
   5 !    6.6   0.1    0.0091       9.5       6      36 ..     518     548 ..     514     594 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00051
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleia 33 
                 +l++ a+ l++lg +d+Ale ++ka+ei+
  EFC37317.1 233 LLTRKALGLHKLGALDKALETCDKAIEIM 261
                 45678999*******************98 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00075
      TPR_12   4 talnnlaavlrrlgrydeAlellekale 31 
                  a+  +a+ +++lg+ ++Al+ l++ le
  EFC37317.1 300 EAYLCRAVSYLKLGDTEKALTDLNTLLE 327
                 3444555555555555555555555555 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 0.00018
      TPR_12   4 talnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleea 71 
                  a+  +a+ +++lg+ ++Al+ l++ le++     p       +l   + +y+  + y+ A+   e+a
  EFC37317.1 300 EAYLCRAVSYLKLGDTEKALTDLNTLLEAH-----PS---RFDALTKRAAIYFSKKMYDSAILDVERA 359
                 578789********************9988.....43...4667777777777777777777666666 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 7.8e-05
      TPR_12  22 AlellekaleiarrllGpdhpltattlrnLgrl.yralgryeeAlelleeala 73 
                 A + +++a+ +        +p+ a +++  g l y ++g+ ++Ale l++a++
  EFC37317.1 403 AVKAFDEAIKV--------NPDDAVSYHQRGLLqYNYMGDSKAALEDLQQAID 447
                 44444444333........5567**********556***************87 PP

  == domain 5  score: 6.6 bits;  conditional E-value: 0.0091
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrl 36 
                  + +++++  + + ++ +el+ ka+e+a+  
  EFC37317.1 518 ITSMGSIHILMNENEQGIELFTKAIEVAKPK 548
                 4569999*9******************9755 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0     0.038        40       8      35 ..     238     265 ..     232     275 .. 0.81
   2 !   16.7   0.1     9e-06    0.0095       2      42 ..     300     340 ..     299     353 .. 0.93
   3 !   11.5   0.0   0.00041      0.43      13      38 ..     396     421 ..     389     428 .. 0.83
   4 ?   -0.9   0.0         4   4.2e+03      11      30 ..     429     448 ..     421     451 .. 0.76
   5 ?   -2.0   0.0       9.4   9.9e+03       9      31 ..     523     545 ..     519     553 .. 0.75
   6 ?    3.7   0.0      0.13   1.4e+02      17      39 ..     579     601 ..     555     605 .. 0.66

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.038
      TPR_14   8 aeallalGdpdeAiallrralalaPdda 35 
                 a  l  lG +d+A++ +++a++  Pd+ 
  EFC37317.1 238 ALGLHKLGALDKALETCDKAIEIMPDFS 265
                 5567889***************999875 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 9e-06
      TPR_14   2 eallalaeallalGdpdeAiallrralalaPddaeawllla 42 
                 ea+l++a  +l lGd+++A++ l+ +l+++P+  +a++  a
  EFC37317.1 300 EAYLCRAVSYLKLGDTEKALTDLNTLLEAHPSRFDALTKRA 340
                 89*****************************9998887766 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 0.00041
      TPR_14  13 alGdpdeAiallrralalaPddaeaw 38 
                 ++ + ++A++++++a++ +Pdda+ +
  EFC37317.1 396 TRNQIADAVKAFDEAIKVNPDDAVSY 421
                 67899*****************9755 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 4
      TPR_14  11 llalGdpdeAiallrralal 30 
                 +   Gd ++A++ l++a+++
  EFC37317.1 429 YNYMGDSKAALEDLQQAIDK 448
                 45578899999999999875 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 9.4
      TPR_14   9 eallalGdpdeAiallrralala 31 
                 +++    + ++ i+l+ +a++ a
  EFC37317.1 523 SIHILMNENEQGIELFTKAIEVA 545
                 55666678899999999999854 PP

  == domain 6  score: 3.7 bits;  conditional E-value: 0.13
      TPR_14  17 pdeAiallrralalaPddaeawl 39 
                  + A++ ++ a++l+P+++ ++ 
  EFC37317.1 579 NELALKDYDMAIKLNPNNPLFYH 601
                 5569999***********99876 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       3.8     4e+03      45      63 ..     242     260 ..     237     264 .. 0.82
   2 !   24.9   0.0   2.2e-08   2.3e-05       4      62 ..     306     362 ..     305     367 .. 0.90
   3 !    8.9   0.4    0.0023       2.4      11      32 ..     398     419 ..     396     447 .. 0.76
   4 ?    1.7   0.1      0.41   4.3e+02      10      27 ..     432     449 ..     429     453 .. 0.88
   5 ?   -0.1   0.0       1.5   1.6e+03      33      67 ..     561     596 ..     532     597 .. 0.66
   6 ?   -0.1   0.0       1.5   1.6e+03      13      32 ..     579     598 ..     572     607 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 3.8
      TPR_16  45 lrqgrlaeAaalyraalra 63 
                  ++g l++A++ +++a++ 
  EFC37317.1 242 HKLGALDKALETCDKAIEI 260
                 57899*****999999865 PP

  == domain 2  score: 24.9 bits;  conditional E-value: 2.2e-08
      TPR_16   4 araalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAa.alyraalr 62 
                 a ++l++gd ++A+  l+++l+++   P + +Al  ++ +++ ++ ++ A+ ++ ra + 
  EFC37317.1 306 AVSYLKLGDTEKALTDLNTLLEAH---PSRFDALTKRAAIYFSKKMYDSAIlDVERAIYY 362
                 668*********************...************************777777665 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0023
      TPR_16  11 gdyddAaaaleaalkrdpssPd 32 
                 ++ +dA++a+++a+k +p++ +
  EFC37317.1 398 NQIADAVKAFDEAIKVNPDDAV 419
                 7889*************55544 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.41
      TPR_16  10 agdyddAaaaleaalkrd 27 
                  gd  +A++ l++a++++
  EFC37317.1 432 MGDSKAALEDLQQAIDKR 449
                 69999**********998 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 1.5
      TPR_16  33 aaeAllllgdaalrq.grlaeAaalyraalraapda 67 
                  a+A+++++ ++  +  + ++A+  y+ a++  p++
  EFC37317.1 561 MAAAYFNRAHVYHMKiINNELALKDYDMAIKLNPNN 596
                 566666666666544345555555555555555555 PP

  == domain 6  score: -0.1 bits;  conditional E-value: 1.5
      TPR_16  13 yddAaaaleaalkrdpssPd 32 
                  + A++ ++ a+k++p  P+
  EFC37317.1 579 NELALKDYDMAIKLNPNNPL 598
                 67899999999999977776 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0       1.2   1.2e+03      11      28 ..     242     259 ..     235     263 .. 0.79
   2 !   15.2   0.0   2.4e-05     0.025       5      31 ..     304     330 ..     300     331 .. 0.89
   3 ?   -1.3   0.1       4.3   4.5e+03       1      20 [.     334     353 ..     334     354 .. 0.87
   4 ?    3.8   0.0       0.1   1.1e+02      14      32 ..     398     416 ..     389     417 .. 0.85
   5 !   10.9   0.1   0.00055      0.58       3      29 ..     421     448 ..     419     451 .. 0.91
   6 ?   -0.7   0.0       2.8     3e+03       6      28 ..     521     543 ..     520     544 .. 0.86
   7 ?    0.9   0.0      0.84   8.9e+02       2      32 ..     564     595 ..     563     596 .. 0.79
   8 ?   -2.1   0.0       7.8   8.2e+03      13      22 ..     617     626 ..     601     629 .. 0.48

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHHHHHHHH CS
       TPR_6  11 rklgdtdkAlealerlik 28 
                  klg  dkAle+ ++ i+
  EFC37317.1 242 HKLGALDKALETCDKAIE 259
                 567899******999987 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 2.4e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHH-T CS
       TPR_6   5 klalsyrklgdtdkAlealerlikeYP 31 
                  +a sy+klgdt+kAl+ l+ l++ +P
  EFC37317.1 304 CRAVSYLKLGDTEKALTDLNTLLEAHP 330
                 5799*********************99 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 4.3
                 HHHHHHHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrklgdtdkAl 20 
                 dAl k+a  y++ + +d A+
  EFC37317.1 334 DALTKRAAIYFSKKMYDSAI 353
                 78999999***988999886 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.1
                 HHHHHHHHHHHHHHHH-TT CS
       TPR_6  14 gdtdkAlealerlikeYPd 32 
                 ++ ++A++a+++ ik  Pd
  EFC37317.1 398 NQIADAVKAFDEAIKVNPD 416
                 6999***********9998 PP

  == domain 5  score: 10.9 bits;  conditional E-value: 0.00055
                 HHHHHHHHHH.HHHHHHHHHHHHHHHHH CS
       TPR_6   3 lyklalsyrk.lgdtdkAlealerlike 29 
                 + +++l++++ +gd+ +Ale l++ i++
  EFC37317.1 421 YHQRGLLQYNyMGDSKAALEDLQQAIDK 448
                 6789**********************98 PP

  == domain 6  score: -0.7 bits;  conditional E-value: 2.8
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAlealerlik 28 
                 ++  ++ +++ ++ +e++ + i+
  EFC37317.1 521 MGSIHILMNENEQGIELFTKAIE 543
                 57788889999*******99986 PP

  == domain 7  score: 0.9 bits;  conditional E-value: 0.84
                 HHHHHHHHHH.H.HHHHHHHHHHHHHHHHH-TT CS
       TPR_6   2 Alyklalsyr.k.lgdtdkAlealerlikeYPd 32 
                 A++++a  y  k   + + Al+ ++  ik  P+
  EFC37317.1 564 AYFNRAHVYHmKiI-NNELALKDYDMAIKLNPN 595
                 78888877775666.888999999999999998 PP

  == domain 8  score: -2.1 bits;  conditional E-value: 7.8
                 HHHHHHHHHH CS
       TPR_6  13 lgdtdkAlea 22 
                  +d d+A+++
  EFC37317.1 617 KKDEDTAKKI 626
                 2466666655 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.059        63      37      59 ..     243     266 ..     240     272 .. 0.79
   2 !   15.2   0.0   2.3e-05     0.024       5      59 ..     279     333 ..     276     342 .. 0.88
   3 ?    4.9   0.0     0.037        39       5      25 ..     398     418 ..     396     424 .. 0.79
   4 ?    1.1   0.1      0.54   5.6e+02       4      20 ..     432     448 ..     430     467 .. 0.86
   5 ?    1.9   0.2       0.3   3.2e+02      10      46 ..     582     618 ..     579     643 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.059
      TPR_19  37 algqldeAealLdalpeedpd.da 59 
                 +lg ld+A +++d++ e  pd ++
  EFC37317.1 243 KLGALDKALETCDKAIEIMPDfSP 266
                 789999999999999999888335 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 2.3e-05
      TPR_19   5 gdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpdda 59 
                 ++++e +++  + l+ + +n ea l  A  +l+lg++++A   L++l+e+ p   
  EFC37317.1 279 EKPQESIEACNKTLSIEEGNMEAYLCRAVSYLKLGDTEKALTDLNTLLEAHPSRF 333
                 6789999999***************99************************9843 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.037
      TPR_19   5 gdyaeAlalleqalqedpkna 25 
                 ++ a+A++++ +a++ +p++a
  EFC37317.1 398 NQIADAVKAFDEAIKVNPDDA 418
                 577888888888888888875 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.54
      TPR_19   4 egdyaeAlalleqalqe 20 
                 +gd  +Al+ l+qa+++
  EFC37317.1 432 MGDSKAALEDLQQAIDK 448
                 89***********9875 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.3
      TPR_19  10 AlalleqalqedpknaearllLAeallalgqldeAea 46 
                 Al+ +  a++ +p+n+    +   +++ +g+ + A++
  EFC37317.1 582 ALKDYDMAIKLNPNNPLFYHYRSMLHIHMGNDELAKK 618
                 78888999999*****999999999999999999975 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.63   6.6e+02      10      30 ..     242     262 ..     234     266 .. 0.80
   2 !    6.5   0.0    0.0089       9.4       6      34 ..     306     334 ..     301     336 .. 0.83
   3 ?   -2.6   0.0       7.2   7.6e+03       5      20 ..     339     354 ..     335     365 .. 0.73
   4 ?    2.1   0.1      0.23   2.4e+02       5      28 ..     424     446 ..     414     454 .. 0.56
   5 ?    3.3   0.0     0.095     1e+02       2      29 ..     518     545 ..     517     553 .. 0.84
   6 ?   -2.2   0.0       5.4   5.7e+03      13      21 ..     584     592 ..     581     593 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.63
       TPR_7  10 srlGdyeeAielyeqsLaltk 30 
                 ++lG  ++A+e + +++++  
  EFC37317.1 242 HKLGALDKALETCDKAIEIMP 262
                 6789999****9999777765 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0089
       TPR_7   6 arlysrlGdyeeAielyeqsLaltkdped 34 
                 a+ y +lGd+e+A++ +  +L+ + + +d
  EFC37317.1 306 AVSYLKLGDTEKALTDLNTLLEAHPSRFD 334
                 788***********988888877777666 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 7.2
       TPR_7   5 LarlysrlGdyeeAie 20 
                  a +y++   y+ Ai 
  EFC37317.1 339 RAAIYFSKKMYDSAIL 354
                 5778999889999885 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.23
       TPR_7   5 Larl.ysrlGdyeeAielyeqsLal 28 
                  + l y  +Gd + A+e ++q  a+
  EFC37317.1 424 RGLLqYNYMGDSKAALEDLQQ--AI 446
                 344422236666666666666..55 PP

  == domain 5  score: 3.3 bits;  conditional E-value: 0.095
       TPR_7   2 LlnLarlysrlGdyeeAielyeqsLalt 29 
                 +  +++++  +++ e+ iel++++++++
  EFC37317.1 518 ITSMGSIHILMNENEQGIELFTKAIEVA 545
                 5689*******************55544 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 5.4
       TPR_7  13 GdyeeAiel 21 
                  dy+ Ai+l
  EFC37317.1 584 KDYDMAIKL 592
                 59*****97 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.0   0.00048      0.51       4      79 ..     246     322 ..     243     325 .. 0.88
   2 ?    1.3   0.1      0.39   4.1e+02      15      49 ..     325     359 ..     322     370 .. 0.73
   3 ?    2.0   0.1      0.23   2.4e+02       2      52 ..     397     449 ..     396     459 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00048
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaL 79 
                 ++++A+  ++++ + +++ + + +  A +++ +++ ++ +e ++k+  +++ ++++ ++ A ++lkL+  e+A++ L
  EFC37317.1 246 ALDKALETCDKAIEIMPDFSPSYLVRASTFLFMEKPQESIEACNKTlSIEEGNMEAYLCRAVSYLKLGDTEKALTDL 322
                 67899999999997777777777777***********************************************9855 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.39
                 HH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  15 llaaetespedayllAlclylngqykrAyellrka 49 
                 ll+a++ + +++   A  +++ + y++A+  +++a
  EFC37317.1 325 LLEAHPSRFDALTKRAAIYFSKKMYDSAILDVERA 359
                 55667777777777799999999999999888877 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.23
                 TT-HHHHHHHHHHHH.HHH--HHHHHHHHHHHHH.TT-HHHHHHHHHCT.SHH CS
      ANAPC3   2 qnnyknAiflaerllaaetespedayllAlclyl.ngqykrAyellrka.kln 52 
                 +n++ +A+  ++ + + +++++ + +  +l  y+ +g+ k A+e l++a +++
  EFC37317.1 397 RNQIADAVKAFDEAIKVNPDDAVSYHQRGLLQYNyMGDSKAALEDLQQAiDKR 449
                 58999999999999999999999999989988876899999999999994443 PP

>> TPR_20  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0    0.0011       1.2       5      54 ..     282     331 ..     278     353 .. 0.88
   2 !    7.2   0.2    0.0062       6.5       6      54 ..     402     451 ..     397     464 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.0011
      TPR_20   5 apelaeleaalaanpddldarldlAlallaagryeeAleqLleilkrdrk 54 
                 ++++++  ++l  +  +++a l  A  +l+ g+ e+Al+ L ++l+++ +
  EFC37317.1 282 QESIEACNKTLSIEEGNMEAYLCRAVSYLKLGDTEKALTDLNTLLEAHPS 331
                 678999999999******************************99998865 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0062
      TPR_20   6 pelaeleaalaanpddldarldlAl.allaagryeeAleqLleilkrdrk 54 
                   ++++++a++ npdd    ++  l +++  g+ ++Ale L + + + ++
  EFC37317.1 402 DAVKAFDEAIKVNPDDAVSYHQRGLlQYNYMGDSKAALEDLQQAIDKRSS 451
                 5789999***********9999997267789**********999887665 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00099         1       8      34 ..     238     264 ..     237     266 .. 0.95
   2 ?   -0.4   0.0       1.2   1.2e+03      19      37 ..     283     301 ..     282     303 .. 0.87
   3 !    7.5   0.0     0.004       4.2       8      33 ..     306     331 ..     301     342 .. 0.89
   4 ?   -1.6   0.0       2.8     3e+03      13      34 ..     575     596 ..     573     597 .. 0.63

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00099
                 HHHHHHHT-HHHHHHHHHHHHHHTTS- CS
  Fis1_TPR_C   8 AlGhyklgeYseArryvdalLeiEPen 34 
                 AlG  klg  ++A++ +d  +ei P++
  EFC37317.1 238 ALGLHKLGALDKALETCDKAIEIMPDF 264
                 89**********************997 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHHTTS-HHH CS
  Fis1_TPR_C  19 eArryvdalLeiEPenrQa 37 
                 e+ + ++  L+iE +n+ a
  EFC37317.1 283 ESIEACNKTLSIEEGNMEA 301
                 5678899*********987 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.004
                 HHHHHHHT-HHHHHHHHHHHHHHTTS CS
  Fis1_TPR_C   8 AlGhyklgeYseArryvdalLeiEPe 33 
                 A+ ++klg+ ++A+  +++lLe +P+
  EFC37317.1 306 AVSYLKLGDTEKALTDLNTLLEAHPS 331
                 899**********************7 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 2.8
                 HHT-HHHHHHHHHHHHHHTTS- CS
  Fis1_TPR_C  13 klgeYseArryvdalLeiEPen 34 
                 k+ + + A++  d+ +++ P+n
  EFC37317.1 575 KIINNELALKDYDMAIKLNPNN 596
                 5555566677777777777776 PP

>> DUF357  Protein of unknown function (DUF357)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       4.1   4.3e+03      20      39 ..     151     170 ..     136     176 .. 0.59
   2 ?   -3.2   0.0       8.7   9.2e+03      35      53 ..     266     284 ..     247     289 .. 0.68
   3 ?    8.3   0.0    0.0023       2.4      33      56 ..     298     321 ..     293     323 .. 0.91
   4 ?   -2.7   0.0       6.2   6.6e+03       2      24 ..     431     453 ..     430     456 .. 0.76
   5 ?    2.6   0.1      0.14   1.4e+02       5      44 ..     537     572 ..     535     577 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 4.1
                 TS---HHHHHHHHHHHHHHH CS
      DUF357  20 esplgeaaeevlemaesYle 39 
                 e+ ++e a+ ++   e+Y++
  EFC37317.1 151 EKDVNEFADAIISTFEKYAT 170
                 35566666666666666655 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 8.7
                 HHHHHHHHHHHHTT-HHHH CS
      DUF357  35 esYleDakyflekgdlvnA 53 
                  sYl  a +fl  +++ ++
  EFC37317.1 266 PSYLVRASTFLFMEKPQES 284
                 4788888888877666655 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0023
                 HHHHHHHHHHHHHHTT-HHHHHHH CS
      DUF357  33 maesYleDakyflekgdlvnAlas 56 
                 ++e+Yl  a  +l+ gd+++Al  
  EFC37317.1 298 NMEAYLCRAVSYLKLGDTEKALTD 321
                 689******************986 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 6.2
                 HHHHHHHHHHHHH.....TS--- CS
      DUF357   2 Yirlleealekvkiapdeesplg 24 
                 Y    + ale+++ a d++s+l+
  EFC37317.1 431 YMGDSKAALEDLQQAIDKRSSLT 453
                 55666889999998889999886 PP

  == domain 5  score: 2.6 bits;  conditional E-value: 0.14
                 HHHHHHHHHH.....TS---HHHHHHHHHHHHHHHHHHHH CS
      DUF357   5 lleealekvkiapdeesplgeaaeevlemaesYleDakyf 44 
                 l+++a+e +k    +++  g   e   ema +Y++ a  +
  EFC37317.1 537 LFTKAIEVAK----PKTASGYTPELRSEMAAAYFNRAHVY 572
                 5566666666....4444444677789*********9987 PP

>> PTS_IIA  PTS system, Lactose/Cellobiose specific IIA subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       1.2   1.3e+03      10      56 ..     296     338 ..     291     342 .. 0.75
   2 ?   -2.6   0.0       5.8   6.1e+03      28      48 ..     392     412 ..     386     415 .. 0.80
   3 ?    8.1   0.1    0.0026       2.8      17      66 ..     538     589 ..     533     593 .. 0.76
   4 ?   -1.8   1.0       3.2   3.4e+03      22      52 ..     613     643 ..     603     648 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.2
     PTS_IIA  10 aGeArslameAlkaakegdfeeaeellkeAeeelkeAhkaqteliqk 56 
                  G+   ++  A++ +k gd e+a   l+     l eAh +  + ++k
  EFC37317.1 296 EGNMEAYLCRAVSYLKLGDTEKALTDLN----TLLEAHPSRFDALTK 338
                 6888889999999999999999988875....466677666666666 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 5.8
     PTS_IIA  28 dfeeaeellkeAeeelkeAhk 48 
                  f++ ++++++A +++ eA k
  EFC37317.1 392 LFNKTRNQIADAVKAFDEAIK 412
                 578889999999999988866 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.0026
     PTS_IIA  17 ameAlkaakegdfeeaeell..keAeeelkeAhkaqteliqkeasgekvevs 66 
                 + +A++ ak +  +    +l  + A   +++Ah +++++i++e + +++++ 
  EFC37317.1 538 FTKAIEVAKPKTASGYTPELrsEMAAAYFNRAHVYHMKIINNELALKDYDMA 589
                 56777777777776665554226799*****************988877765 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 3.2
     PTS_IIA  22 kaakegdfeeaeellkeAeeelkeAhkaqte 52 
                 +++ ++d ++a++  +  +e +k+ +k+q+e
  EFC37317.1 613 DELAKKDEDTAKKITERQQERIKQMQKLQQE 643
                 5667777888888888888888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (651 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1431  (0.0798148); expected 358.6 (0.02)
Passed bias filter:                      645  (0.0359752); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 3854.67
//
Query:       EFC37318.1  [L=1320]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.7e-13   50.0   3.7    2.7e-13   50.0   3.7    2.8  3  Sec8_exocyst  Sec8 exocyst complex component specific domain


Domain annotation for each model (and alignments):
>> Sec8_exocyst  Sec8 exocyst complex component specific domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.0   3.7   1.5e-17   2.7e-13      30     140 ..     104     212 ..      75     214 .. 0.88
   2 ?   -1.4   0.0      0.11     2e+03      47      71 ..     387     411 ..     376     420 .. 0.84
   3 ?   -3.7   0.1      0.55   9.8e+03     104     125 ..    1245    1266 ..    1236    1273 .. 0.76

  Alignments for each domain:
  == domain 1  score: 50.0 bits;  conditional E-value: 1.5e-17
  Sec8_exocyst  30 llDdssvGlahrlkefkqlkkqieeaLqevvnehhqaFnssiasYskilssiqesqekvselKesleeakkklstkkkeLkelnarsakykevieiL 126
                   +l + +    ++l+++k+ kk +++a++++v  ++++Fn+si ++s +l+ +++ q++v+++ e+++ +k+ l  ++ +L  l  + +++ke+++iL
    EFC37318.1 104 SLKNGT--DKEDLRKLKDNKKFLDDAVKQIVCVNYKGFNKSIRNFSDMLDLMEKGQSQVQNMIEKVRTTKELLALRSTDLISLYSSYLQQKEILDIL 198
                   554444..46789999********************************************************************************* PP

  Sec8_exocyst 127 daieelkkvpdkie 140
                   d ++++k+ p++i 
    EFC37318.1 199 DVVQKVKNAPNEIT 212
                   ***********996 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.11
  Sec8_exocyst  47 qlkkqieeaLqevvnehhqaFnssi 71 
                   +l +++  +L++ ++ h + F++s 
    EFC37318.1 387 KLVQNLRFELRHLIESHINEFANSL 411
                   56677788999**********9996 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 0.55
  Sec8_exocyst  104 tkkkeLkelnarsakykeviei 125 
                     + k+Lk+l  +  +y+ ++++
    EFC37318.1 1245 IETKSLKQLPFTQDQYEAILQT 1266
                    5678899999999999888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1775  (0.0990016); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.06u 0.33s 00:00:01.39 Elapsed: 00:00:00.52
# Mc/sec: 7683.81
//
Query:       EFC37319.1  [L=139]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.7e-20   71.9   0.2    9.7e-20   71.5   0.2    1.1  1  Ribosomal_L27A  Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27


Domain annotation for each model (and alignments):
>> Ribosomal_L27A  Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.5   0.2   5.4e-24   9.7e-20       3     127 ..      18     136 ..      16     137 .. 0.85

  Alignments for each domain:
  == domain 1  score: 71.5 bits;  conditional E-value: 5.4e-24
                     GGTSSTTTTTTTTT-..S--........S--.........---GGG..---EEEEHHHHHHTTTTGTTS--......----EEEGGGTTTTSSS. CS
  Ribosomal_L27A   3 ktgGrGhkGqkkrsg..vkk.kpg.feGGqmplyrrlpkrGfknskfkkeykvvnlkdLdelideerlela......deaeeidleelaeaglik 87 
                     ++gGrG++G +++++  v++ +pg f  G+      + ++++++++    ++ +n+++L++++ +e+ ++a      ++a +id+ +        
      EFC37319.1  18 HPGGRGMAGGQHHHRiwVDRfHPGyF--GKI----GIRRFHMNKNH--FLTNCLNVDELWKVAGQEVYQQAkegkfgGKAVVIDAHKA------- 97 
                     78*************999999***89..**9....44444554433..44489**************995558887777888888888....... PP

                     ...SE.EEE--S---..--EEEESEE-HHHHHHHHHTT-EEE CS
  Ribosomal_L27A  88 kkdgv.Kvlgkgeltk.klkvkaskfSkkAkekIeaaGGkve 127
                        g+ K++g+g+l+k ++ v+a+ fSk+A+ekI+a GG +e
      EFC37319.1  98 ---GFdKIMGRGDLPKiPIVVRARLFSKSAEEKIKAIGGVCE 136
                     ...***********9967**********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (139 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       323  (0.0180155); expected 358.6 (0.02)
Passed bias filter:                      271  (0.0151152); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 865.51
//
Query:       EFC37320.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.5   0.0        0.2   11.6   0.0    1.4  1  APC_u13   Unstructured region on APC between APC_crr and SAMP


Domain annotation for each model (and alignments):
>> APC_u13  Unstructured region on APC between APC_crr and SAMP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   1.1e-05       0.2       7      32 ..      97     122 ..      96     126 .] 0.94

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.1e-05
     APC_u13   7 ELanaesvstGaesaefEkRDtiPTE 32 
                 EL n  ++s+G ++  f k  tiPTE
  EFC37320.1  97 ELNNQSETSSGRKKSLFKKAQTIPTE 122
                 999**********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1016  (0.056668); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.25s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 927.34
//
Query:       EFC37321.1  [L=1287]
Description: MgtA domain/ATPase domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-62  212.0  13.4    1.2e-62  212.0  13.4    2.3  3  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t
    1.6e-22   78.9   1.2    4.7e-22   77.4   1.2    1.9  1  PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
    4.4e-17   62.0   0.9    5.2e-15   55.3   0.0    2.9  3  Cation_ATPase    Cation transport ATPase (P-type)
    4.3e-13   50.0   0.2    5.5e-08   33.3   0.0    3.4  2  Hydrolase        haloacid dehalogenase-like hydrolase
    1.4e-08   34.5   0.9    1.4e-08   34.5   0.9    2.9  3  E1-E2_ATPase     E1-E2 ATPase
    0.00019   21.2   0.5    0.00019   21.2   0.5    3.0  4  Hydrolase_3      haloacid dehalogenase-like hydrolase
  ------ inclusion threshold ------
      0.062   13.5   0.1       0.21   11.8   0.1    1.9  1  SRTM1            Serine-rich and transmembrane domain-contain


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.2       1.4   3.7e+03     213     237 ..     230     252 ..     212     256 .. 0.55
   2 ?   -2.8   1.4       1.6   4.2e+03     210     224 ..     492     506 ..     435     550 .. 0.46
   3 !  212.0  13.4   4.5e-66   1.2e-62       2     249 .]    1008    1257 ..    1007    1257 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.4
  PhoLip_ATPase_C 213 eelfsspsfwlvlllvvvvallpdl 237
                      e++ + ++  ++lll+v+++l+pdl
       EFC37321.1 230 EQFRKAIN--VYLLLTVIAVLIPDL 252
                      22222233..346688888888887 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.6
  PhoLip_ATPase_C 210 gvleelfsspsfwlv 224
                      g+++ +f+s  f+l 
       EFC37321.1 492 GNFHDTFESGAFYLA 506
                      223333333333332 PP

  == domain 3  score: 212.0 bits;  conditional E-value: 4.5e-66
  PhoLip_ATPase_C    2 raSDyaiaqFrfLkrLLlvhGrwsyrRisklilyffyKnvvftlvqfwfqfyngfsgqslyeswlltlynllftslpvivlgifdqdvsael 93  
                       r+SD++i++F+ L rLL vhGr++  R++ ++  +fyKn+++ l+qf+  fy+g+sg+ +++sw l++y  ++ ++++i++g  ++d+++e+
       EFC37321.1 1008 RSSDFSIPRFKNLVRLLAVHGRNCSVRNADFLHLSFYKNFILLLPQFFNIFYCGYSGTLIFDSWELIVYIGIYFFFQPIAFGSCEKDLPEEV 1099
                       89****************************************************************************************** PP

  PhoLip_ATPase_C   94 llkyPelYklgqknk.lfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvaletktwtliliili 184 
                       +l++PelY +++k+  lfnl+t+++w ++++y++l+iff ++l++d   f ++  +dl+ fg +++t++v+vv+l  +le+kt t+ ++il+
       EFC37321.1 1100 ILEHPELYDSLKKSGnLFNLRTLIMWGIAAIYHALVIFFGIILSVDGD-FMENGPTDLYHFGKIIMTCMVCVVTLIYILEIKTLTVPVLILM 1190
                       *********8886444************************99999766.55888999*********************************** PP

  PhoLip_ATPase_C  185 lgsillyflflllyssllps..ssefygvleelfsspsfwlvlllvvvvallpdllikvlkrtffps 249 
                        + +l+yf+f++ ys +     + e + +++e+f s++  l+++lvvvva+lp++++k+ k tffps
       EFC37321.1 1191 PLGFLFYFAFNACYSPIADElgDPESLYIYYETFVSVQATLTTILVVVVAILPNIIWKAAKITFFPS 1257
                       ***************999889966666689**********************************996 PP

>> PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.4   1.2   1.8e-25   4.7e-22       1      62 [.     193     256 ..     193     261 .. 0.93

  Alignments for each domain:
  == domain 1  score: 77.4 bits;  conditional E-value: 1.8e-25
  PhoLip_ATPase_N   1 vyindreene..kkkyasNkIsTsKYtlltFlpknLfeqFrrvaNlYFLviailqliPqispls 62 
                      +yin+reen+  +k +++N+++T+KY++ltF+pknLfeqFr++ N+Y L+++i  liP++sp+ 
       EFC37321.1 193 IYINNREENRkcRKPFPKNSVTTTKYSILTFIPKNLFEQFRKAINVYLLLTVIAVLIPDLSPMF 256
                      79***998887777***********************************************985 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       2.9   7.4e+03      37      69 ..     163     199 ..     108     204 .. 0.63
   2 !   55.3   0.0     2e-18   5.2e-15      18      89 ..     679     762 ..     660     763 .. 0.79
   3 ?    3.9   0.0     0.022        55      16      36 ..     860     891 ..     834     917 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.9
  Cation_ATPase  37 ldteelreetkkvqeipFns....srKrmsvvlklep 69 
                    + +ee ++e + v++  F s    +rK+  +++++++
     EFC37321.1 163 ELKEETQQEVEPVEKSNFASedetERKFEKIYINNRE 199
                    4445555555555555555411114666666666554 PP

  == domain 2  score: 55.3 bits;  conditional E-value: 2e-18
  Cation_ATPase  18 kllG.nktEsALlvlaeklgldteelree............tkkvqeipFnssrKrmsvvlklepekkvrlyvKGApeiilkrCt 89 
                    ++ G + +E+ALl++a + g + ++  +e            +++++++pF+s+rKrm+v++k+ +e+++++yvKGA +++lkrC 
     EFC37321.1 679 NYNGpSSDEIALLEAATNNGFKLIQRTNEglvidemgetrfYEIIATFPFTSDRKRMTVLVKT-QEGRYIAYVKGADNVMLKRCR 762
                    45553678***********6666666666666666666666*********************9.7*******************6 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.022
  Cation_ATPase  16 evkllGnktEsALlvlaekl...........g 36 
                     + l+G+ktE+A+  + +              
     EFC37321.1 860 IWVLTGDKTETAINIAYSTNvlvkdktieirI 891
                    5889********98777666677666665553 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.0   2.2e-11   5.5e-08       4     186 ..     582     908 ..     579     918 .. 0.67
   2 !   11.6   0.1   9.7e-05      0.25     171     209 ..     953     992 ..     899     993 .. 0.69

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 2.2e-11
                 EEEESBTTTBCHHHHHHHHHHHH............CHHHHHHHHHH........HHCHHHHHHHHHHHHH............HHHHHHHHHETTTE... CS
                 xxxxxxxxxxxxxxxxxxxxxxx............xxxxxxxxxxx........xxxxxxxxxxxxxxxx............xxxxxxxxxxxxxx... RF
   Hydrolase   4 vvfDkdGTLttgepsvedvivsa............alalaaaletg........sehpigkalvaaakar............sgaltgfatfigrg... 67 
                 ++ Dk+GTLt+ e+   d +               +  ++ +  +          +h++++  v+ a+++                         +   
  EFC37321.1 582 IFSDKTGTLTQNEMKYSDSWTDGmyyseksnpgsmK--EKLVQYHQfgkidienQPHHHQQTSVHGAEHHascirefltcltL------------Nnsv 666
                 889********************7777777777433..333333334477788888888888888888884444433333220............1333 PP

                 ............................................HHHHTHHHHHHHHHCHHHHHHHHHHHHHHCHHHHHH................... CS
                 ............................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................... RF
   Hydrolase  68 ............................................ayaigkpewltaldippdlgaaigsaqsqgrtvall................... 103
                                                                                                +                   
  EFC37321.1 667 mpekdlqnperinyngpssdeialleaatnngfkliqrtneglvI----------------------------------Demgetrfyeiiatfpftsd 731
                 332223333333333344444444444444444444444444441..................................04444444444455555555 PP

                 .................................................................................................TT CS
                 .................................................................................................xx RF
   Hydrolase 104 .................................................................................................qa 105
                                                                                                                  + 
  EFC37321.1 732 rkrmtvlvktqegryiayvkgadnvmlkrcrarkeyvhelksallnfsvqglrtlvigrrelsmsefetwfdgynkasmssknrgkmiaqsasdleiDL 830
                 555555555666666666677777777777777777777777777777777777777999999999999999999999999999999999999999999 PP

                 HHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHHTTGGGE.SEEEEHHCESSTTTSHHHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 106 ralavftiadplkvkpeaaeavasLkaagievvlltgdnpetaeraanqlGddyf.daviasdietvakpspegkvaaireL 186
                 ++++  +i+d+  + +++a+ + +L +ag+++++ltgd  eta  +a   +   + d +i++ i   a  ++++k+++ + L
  EFC37321.1 831 ELVGCTAIEDK--LQDDVAKSIDYLSRAGLKIWVLTGDKTETAINIAYSTN-VLVkDKTIEIRIR-DANTHQQAKKKLKEAL 908
                 ***********..**********************************9999.3332333333333.4666666666666665 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 9.7e-05
                 STTTSHHHHHHHHHHHTST.GGGEEEEESSHHHHHHHHHT CS
                 xxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 171 vakpspegkvaaireLqgk.peevamVGDgvnDaaalaaA 209
                 +   +p +k  +++ +  k  ++ + +GDgvnD+a+++aA
  EFC37321.1 953 CCRLKPLQKSSIVKLIESKlHKKALSIGDGVNDVAMIQAA 992
                 44557788888888887555778**************998 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   0.9   5.4e-12   1.4e-08       3     134 ..     290     488 ..     288     525 .. 0.70
   2 ?   -3.4   0.7       2.3   5.9e+03     117     137 ..    1158    1178 ..    1126    1208 .. 0.70
   3 ?   -2.7   0.2       1.4   3.5e+03     144     169 ..    1227    1252 ..    1213    1255 .. 0.64

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 5.4e-12
                   S--EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.....EEE-TTTS---S-EE-.............................. CS
  E1-E2_ATPase   3 lpptakvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa.....evdesaLTGEslpvek.............................. 64 
                   + ++++virdg ++ei++k++++GD+v +k+ ++ paD   +++s       ++++ L GE    ++                              
    EFC37321.1 290 NNEKCRVIRDGILQEIQVKNIEIGDVVSIKKDEVFPADLLCIHSSRedelcYIETANLDGETNLKSRrpikgsskvfhhdvaennigdfaqlkgkvq 386
                   6799**************************************9766566679*********988887777777777777777777777777777777 PP

                   ..................................G-TTEE-TT-EEEE.-EEEEEEEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHH CS
  E1-E2_ATPase  65 ..................................ekgdmvfsGtvvvs.geakavVtatgedtelgkiarlveeakskktplqkkldklgkvlvpvv 126
                                                     + ++ +  G++  + +++ ++++ +g++t   ki   ++e k k+ +l   l+k+  +lv++ 
    EFC37321.1 387 vemannnldvfegmlkmqtqvmgygelisineplTMENLLLRGCTLRNtQHIFGIAIYLGKHT---KIFMNTKENKVKRNELWVTLNKILVFLVLFQ 480
                   776666666666666666666666666666655556666666666655445555666666655...4555555555566666666666666655555 PP

                   HHHHHHHH CS
  E1-E2_ATPase 127 lliallvf 134
                    +++++v+
    EFC37321.1 481 QVLCAIVA 488
                   55555555 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.3
                    HHHHHHHHHHHHHHHHHHHS- CS
  E1-E2_ATPase  117 klgkvlvpvvlliallvflia 137 
                     +gk++++ +++++ l++++ 
    EFC37321.1 1158 HFGKIIMTCMVCVVTLIYILE 1178
                    455555555555555555544 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.4
                    TTHHHHHHHHHHHHHS-TTHHHHHHH CS
  E1-E2_ATPase  144 laeallralallvaaiPcaLplavpl 169 
                    ++ +l+ +l+++va++P  +  a+ +
    EFC37321.1 1227 VQATLTTILVVVVAILPNIIWKAAKI 1252
                    33666778888888888766666555 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.4         3   7.7e+03     149     153 ..      54      58 ..      15      89 .. 0.44
   2 ?    2.3   2.0     0.046   1.2e+02      88     185 ..     131     227 ..     108     234 .. 0.62
   3 ?   -3.6   0.1       2.8   7.2e+03     100     111 ..     599     610 ..     550     649 .. 0.58
   4 !   21.2   0.5   7.5e-08   0.00019      81     227 ..     843     997 ..     832    1003 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 3
                  S-HHH CS
  Hydrolase_3 149 kdkek 153
                  + ++ 
   EFC37321.1  54 DHHSL 58 
                  11111 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.046
                  HHHHHHTTCEEEEEESSEEEESTT.....THHHHHHHHHCHCTCEEEESHHHHHCHCSESEEEEES-HHHHHHHHHHHHHHCTTTEEEEEESTTEEEE CS
  Hydrolase_3  88 ikllkennveillytedkvyvlnk....eksekkkkeeektkkkkeeidseeeledeeiakililkdkekldelekelksklnklltitssskgylei 181
                  +  +k++ v++++y  +k    ++    ek+++ k+e +++ + +e+++  +e+e+e  +  ++++++e+  +++k ++++     ++t+++ ++l +
   EFC37321.1 131 YWKVKDKIVDLMCYVIKKKPLGDDfeleEKEQELKEETQQEVEPVEKSNFASEDETERKFEKIYINNREENRKCRKPFPKN-----SVTTTKYSILTF 223
                  444555556666666555555555786433333333333333333333333334444444444888899999999999999.....788888888888 PP

                  EETT CS
  Hydrolase_3 182 mpkg 185
                  +pk+
   EFC37321.1 224 IPKN 227
                  8876 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 2.8
                  EEESSEEEESTT CS
  Hydrolase_3 100 lytedkvyvlnk 111
                   + +d++y+++k
   EFC37321.1 599 DSWTDGMYYSEK 610
                  222344444444 PP

  == domain 4  score: 21.2 bits;  conditional E-value: 7.5e-08
                  HHHHHHHHHHHHHTTCEEEEEESSEEEESTT............THHHHHHHHHCHCTCEEEESHHHHHCHCSESEEE...EES-HHHHHHHHHHHHHH CS
  Hydrolase_3  81 kedvkeiikllkennveillytedkvyvlnk...........eksekkkkeeektkkkkeeidseeeledeeiakil...ilkdkekldelekelksk 164
                  ++dv + i++l+  +++i++ t dk+ +  +           +  e ++++++++++ k++ ++  e  +++ +k +   ++ d+++l+ + ++++++
   EFC37321.1 843 QDDVAKSIDYLSRAGLKIWVLTGDKTETAINiaystnvlvkdKTIEIRIRDANTHQQAKKKLKEALEFLQNNSNKGFefgLIIDSKSLEFILDKYEKR 940
                  478999999999999999999966665544457888899998444555555555555555555555555555555554449999999*********** PP

                  CTTTEEEEEESTTEEEEEETT-SHHHHHHHHHHHCT--GGGEEEEESSGGGHHHHHHSSEEEE CS
  Hydrolase_3 165 lnklltitssskgyleimpkgvsKgtalkklakelnisleeviafGDgeNDieMLeaaglgvA 227
                  +    +  ++ +  +    k  +K + +k + ++l   +++ +++GDg ND++M++aa +gv 
   EFC37321.1 941 FI---ELARYVHCAVCCRLKPLQKSSIVKLIESKL---HKKALSIGDGVNDVAMIQAASIGVG 997
                  95...7888888899999999**********9777...6899******************996 PP

>> SRTM1  Serine-rich and transmembrane domain-containing protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   8.1e-05      0.21      31      79 ..    1210    1258 ..    1193    1263 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8.1e-05
       SRTM1   31 ssgrlsnvyvyvsiflsllaflllllvialqrlkniisssssypecssd 79  
                    g + ++y+y   f+s+ a l ++lv+ +  l nii  ++ +  ++s+
  EFC37321.1 1210 ELGDPESLYIYYETFVSVQATLTTILVVVVAILPNIIWKAAKITFFPSE 1258
                  4488999******************************998887777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1287 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1482  (0.0826594); expected 358.6 (0.02)
Passed bias filter:                      584  (0.0325729); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.86u 0.24s 00:00:01.10 Elapsed: 00:00:00.43
# Mc/sec: 8997.96
//
Query:       EFC37322.1  [L=481]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    9.7e-11   41.1   7.9    0.00068   19.5   0.0    5.6  5  NHL        NHL repeat
     0.0037   16.6   0.1       0.15   11.3   0.0    2.4  2  Lactonase  Lactonase, 7-bladed beta-propeller
  ------ inclusion threshold ------
       0.15   11.9   1.0       0.26   11.0   1.0    1.3  1  DUF1028    Family of unknown function (DUF1028)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0     0.041   2.4e+02       9      25 ..     120     137 ..     114     140 .. 0.74
   2 !   11.4   0.3   4.5e-05      0.27      12      27 ..     245     260 ..     244     261 .. 0.88
   3 ?    0.9   0.0     0.091   5.5e+02       1      22 [.     280     301 ..     280     305 .. 0.84
   4 !    6.3   0.6    0.0018        11       6      28 .]     350     373 ..     348     373 .. 0.92
   5 !   19.5   0.0   1.1e-07   0.00068       2      26 ..     388     413 ..     388     414 .. 0.95

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.041
                 EE.TTTEEEEEECCCTEE CS
         NHL   9 vd.snGdiyVaDsenhrv 25 
                 ++ +   ++V+D++ +++
  EFC37322.1 120 ISyNHKLVVVSDYNANSL 137
                 45567789****888776 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 4.5e-05
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                  + + V+D++n+r+qv
  EFC37322.1 245 ENLVMVCDFNNNRIQV 260
                 57889**********9 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.091
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 ++ P+ + v+s Gd++ +++ n
  EFC37322.1 280 LQTPWMIDVNSYGDLVLSEFSN 301
                 578999**********998544 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0018
                 EEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   6 Gvavd.snGdiyVaDsenhrvqvF 28 
                 G++vd ++ +++++D+ ++ +++F
  EFC37322.1 350 GIVVDkTTQNVIICDRDSNIIRIF 373
                 99*************999988877 PP

  == domain 5  score: 19.5 bits;  conditional E-value: 1.1e-07
                 SSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvq 26 
                 n+P+G+++d  +G++++ Dse+ +v+
  EFC37322.1 388 NNPRGICIDeRSGELLIVDSERKCVK 413
                 68**********************97 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.013        77      86     115 ..     113     142 ..      97     163 .. 0.65
   2 !   11.3   0.0   2.5e-05      0.15     208     328 ..     296     425 ..     294     434 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.013
                 S-EEEEEE-TTSSEEEEEETTTTEEEEEEB CS
   Lactonase  86 aspchlsvdedgkllavAnYsggsvsvfpl 115
                 ++p  ++++ ++kl++v++Y+++s+  f+l
  EFC37322.1 113 KKPFDVKISYNHKLVVVSDYNANSLFLFDL 142
                 345555555555555555555555555554 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 2.5e-05
                 EETTTTEEEEEEEE-TTTEEEEEEEEESS-T..SS-S-............--EEEEEE-TTSSEEEEEETSSTEEEEEEE-TTT--EEEEEEEE-SSS. CS
   Lactonase 208 vnELsstvsvfsydeatgaleelqtvstlpe..gftgk............nsaaeIrlspdgkflyvSnRgadsiavfavdeadgtltlveevstegkf 292
                 ++E s++v+ ++y ++  +  ++ + + + +  +++ +            +++  I++ +  +++ +++R ++ i +f+v+       +++ev    ++
  EFC37322.1 296 LSEFSNRVQLIRYVSNVYDYMDIAEREEMDSdgWVSLHqfssesnsrnvkTKCCGIVVDKTTQNVIICDRDSNIIRIFNVNG-----IFIKEVRGVINN 389
                 5666666666666655544444444444444221222245555666655589****************************33.....478888888899 PP

                 --EEEE-TTSSEEEEEETTTTEEEEEEEETTTTEEE CS
   Lactonase 293 PRdfaldpsgklllvanqksdnvtvferdaetGkLt 328
                 PR + +d+    ll+++ + + v    ++++ G +t
  EFC37322.1 390 PRGICIDERSGELLIVDSERKCVKRQLMEQQVGTIT 425
                 ******887666666777777777777777777766 PP

>> DUF1028  Family of unknown function (DUF1028)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   1.0   4.4e-05      0.26      32      88 ..     417     471 ..     403     476 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 4.4e-05
                 EETTTEEEEEESS--HHHHHHHHHHHHTT--HHHHHHHHHHT-TTGGG-EEEEEETT CS
     DUF1028  32 aragvGavatQaltnpelgekglelleagasaeealeallaadegrelRQlavvdak 88 
                 ++++vG ++ Q+    ++   +l+l+ + +s +ea+++l + ++   +RQ+ vv  +
  EFC37322.1 417 MEQQVGTITIQQQPTEQVLATILDLMVQQLSHTEAITTLSRVEP--FHRQVMVVIKS 471
                 6899***********************************99998..79****99765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       889  (0.0495845); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 2989.84
//
Query:       EFC37323.1  [L=734]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0042   17.3   1.1      0.012   15.9   1.1    1.8  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.042   13.5   0.1      0.099   12.3   0.1    1.6  1  Imm9      Immunity protein 9
        1.5    9.5   6.4         16    6.2   1.5    3.1  2  DUF2627   Protein of unknown function (DUF2627)
          8    7.0  10.9        2.9    8.4   2.0    3.1  3  PEN-2     Presenilin enhancer-2 subunit of gamma secretase


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   1.1   2.6e-06     0.012       2      92 ..     603     712 ..     602     716 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 2.6e-06
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS............... CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka..keqeelkkkakeIyneylapsspkelnidkklreelekrleke............... 83 
                 +e+l++  +  ++F++F e+efs en  +++  ++++++    +    ++++++y+ ++ p +  e+n + k+r  +e+ ++ +               
  EFC37323.1 603 IEELVKIDAFFEMFKSFSEKEFSLENSLLFERFKQLESSsiGGEAIPPREIEDLYDSFFRPYAIYEVNFSYKTRRDIEAIFQSKkgisindlkaiiefd 701
                 67788888899***************************976566666788*****************************99998777777777777777 PP

                 ..STTTTTTHH CS
         RGS  84 ..qpsrklfee 92 
                    +++++fe+
  EFC37323.1 702 llMNMKDTFER 712
                 77777777776 PP

>> Imm9  Immunity protein 9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   2.2e-05     0.099      83     133 ..      84     133 ..      46     141 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.2e-05
        Imm9  83 skevrwGvkekekfagkpelnekkfkrildvefekYdslnsYiieeaklai 133
                  + + + +kek + +   +ln++k  +i++ +fe Yd+  +Y  +  ++ i
  EFC37323.1  84 GHLLFFTLKEK-NITRAIDLNDRKIAVISHENFEMYDAALQYYSQRNNVTI 133
                 55566778888.667559*******************99999877666655 PP

>> DUF2627  Protein of unknown function (DUF2627)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   1.5    0.0035        16      10      64 ..     385     457 ..     377     460 .. 0.85
   2 ?    4.3   0.2     0.013        59      27      69 ..     534     583 ..     524     587 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0035
     DUF2627  10 vipgllaayGiklmrdalfgilsspfssl..................wlqflaGlllfaiglgfiaGfilhrd 64 
                  i  l+++yG++lmr   + +l    +++                  + +++ G +++ i++ ++  + ++r+
  EFC37323.1 385 SIALLVGVYGVTLMRFYYLRNLYCILKNIperfiklnrflsstgfgiVSSLVCGCVFATISIIYVTTYHFTRE 457
                 4677899********99888888888888888999999999999998889999*************9999998 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.013
     DUF2627  27 lfgilsspfsslwlqflaGlllfaiglgfiaGfi........lhrdrKrnk 69 
                 +f+ + ++++s ++q+l+  ++f+ +++f+ G+         ++r rKr++
  EFC37323.1 534 FFNAFYRTTESYMIQTLFRSITFM-SVYFLCGWTaiimewinFFRRRKRGR 583
                 688888899999999999999986.899**999433344446778888876 PP

>> PEN-2  Presenilin enhancer-2 subunit of gamma secretase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1       1.9   8.4e+03      50      67 ..     323     339 ..     311     364 .. 0.58
   2 ?    3.5   0.2     0.022        98      51      87 ..     431     467 ..     392     472 .. 0.86
   3 ?    8.4   2.0   0.00064       2.9      25      76 ..     529     580 ..     518     591 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.9
       PEN-2  50 yvilSaiGalvwlvvlla 67 
                 yv++ ++Gal +l +l++
  EFC37323.1 323 YVVI-VVGALYYLSLLTV 339
                 4443.4566666555544 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.022
       PEN-2  51 vilSaiGalvwlvvllaWalvfqikraewgevgdkls 87 
                 ++ S++  +v++++ ++++++++ +r++  ++g ++ 
  EFC37323.1 431 IVSSLVCGCVFATISIIYVTTYHFTREQLFSYGSEVV 467
                 678999999*****************98777777664 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.00064
       PEN-2  25 lvNvvyffkeaflkeafeeqkeirkyvilSaiGalvwlvvllaWalvfqikr 76 
                 ++ +++f    +++e++  q+ +r+  ++S+  ++ w+++++ W+ +f  ++
  EFC37323.1 529 ILAILFFNAFYRTTESYMIQTLFRSITFMSVYFLCGWTAIIMEWINFFRRRK 580
                 4556777777788899999999999999***999************998654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (734 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1015  (0.0566122); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.29s 00:00:01.04 Elapsed: 00:00:00.48
# Mc/sec: 4564.86
//
Query:       EFC37324.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.32s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 840.46
//
Query:       EFC37325.1  [L=821]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.3e-33  111.4  11.1    2.5e-07   30.4   0.1   10.5 11  NHL           NHL repeat
    7.3e-07   29.0   1.7     0.0042   16.7   0.0    4.2  3  SGL           SMP-30/Gluconolactonase/LRE-like region
    1.8e-06   28.2   9.1    1.8e-06   28.2   9.1    2.1  2  EGF_2         EGF-like domain
    0.00043   20.5  12.4    0.00087   19.6   6.6    3.0  2  EGF           EGF-like domain
      0.002   18.1   1.5      0.016   15.2   0.4    3.4  3  SBBP          Beta-propeller repeat
     0.0086   16.7   7.9     0.0086   16.7   7.9    3.5  3  hEGF          Human growth factor-like EGF
  ------ inclusion threshold ------
      0.012   15.7   0.8         35    4.6   0.0    5.3  6  Str_synth     Strictosidine synthase
      0.046   13.0   0.0       0.14   11.4   0.0    1.8  2  Lactonase     Lactonase, 7-bladed beta-propeller
       0.12   12.5   6.4       0.28   11.3   6.4    1.5  1  Laminin_EGF   Laminin EGF domain
       0.47   10.4   7.0        2.1    8.3   3.8    3.3  2  cEGF          Complement Clr-like EGF-like
        1.6    8.2   3.3         10    5.6   0.1    2.6  3  Peptidase_A3  Cauliflower mosaic virus peptidase (A3)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.086   1.4e+02       3      19 ..      64      81 ..      62      83 .. 0.87
   2 !   30.4   0.1   1.5e-10   2.5e-07       1      27 [.     162     188 ..     162     189 .. 0.94
   3 !   15.7   0.1   6.7e-06     0.011       1      23 [.     218     240 ..     218     244 .. 0.91
   4 ?    2.4   0.1      0.11   1.8e+02       9      23 ..     282     296 ..     275     300 .. 0.81
   5 !    7.1   0.0    0.0036       5.9       3      16 ..     385     399 ..     384     399 .. 0.93
   6 !    7.2   0.0    0.0035       5.7      11      20 ..     452     462 ..     449     466 .. 0.80
   7 !   13.3   0.0   4.1e-05     0.067       1      23 [.     498     520 ..     498     524 .. 0.88
   8 !   21.3   0.0   1.2e-07   0.00019       1      26 [.     555     580 ..     555     582 .. 0.90
   9 !    6.4   0.0    0.0061        10       2      21 ..     613     632 ..     612     633 .. 0.90
  10 ?   -2.0   0.0       2.8   4.6e+03      16      22 ..     725     731 ..     717     733 .. 0.66
  11 ?   -3.5   0.0       8.3   1.4e+04       3       9 ..     792     798 ..     791     799 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.086
                SEEEEEEE.TTTEEEEEE CS
         NHL  3 yPhGvavd.snGdiyVaD 19
                +P G+a++ + + iy ++
  EFC37325.1 64 RPVGLAYSqKRNTIYLSE 81
                8************99875 PP

  == domain 2  score: 30.4 bits;  conditional E-value: 1.5e-10
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+GvavdsnGd+y++Ds+n  +++
  EFC37325.1 162 LNQPSGVAVDSNGDVYISDSGNGLIRK 188
                 79********************99975 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 6.7e-06
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +++P+G+   +nGd+y+aDs n+
  EFC37325.1 218 LSNPRGLNFGPNGDLYIADSDNN 240
                 689******************98 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.11
                 EETTTEEEEEECCCT CS
         NHL   9 vdsnGdiyVaDsenh 23 
                 v+++++i+++D  n+
  EFC37325.1 282 VSKTNEIFISDADNN 296
                 779********9997 PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.0036
                 SEEEEEEE.TTTEEE CS
         NHL   3 yPhGvavd.snGdiy 16 
                 yP G++v+ ++Gdi+
  EFC37325.1 385 YPKGICVNeNTGDII 399
                 8************96 PP

  == domain 6  score: 7.2 bits;  conditional E-value: 0.0035
                 TTTEEEEEE.C CS
         NHL  11 snGdiyVaD.s 20 
                 +nGd+yVaD +
  EFC37325.1 452 PNGDVYVADyF 462
                 8********54 PP

  == domain 7  score: 13.3 bits;  conditional E-value: 4.1e-05
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +n P++v v+s+++i++aD+ n+
  EFC37325.1 498 LNAPNSVKVSSSDEIVIADTSNN 520
                 577****************8887 PP

  == domain 8  score: 21.3 bits;  conditional E-value: 1.2e-07
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +++P++va+ +nG++++aD +nh ++
  EFC37325.1 555 LSSPSDVAIAPNGEVFIADWGNHVIR 580
                 679********************665 PP

  == domain 9  score: 6.4 bits;  conditional E-value: 0.0061
                 SSEEEEEEETTTEEEEEECC CS
         NHL   2 nyPhGvavdsnGdiyVaDse 21 
                  +P +++++++G+++++D++
  EFC37325.1 613 KFPKSISLSKDGELFISDYN 632
                 6899**************87 PP

  == domain 10  score: -2.0 bits;  conditional E-value: 2.8
                 EEEECCC CS
         NHL  16 yVaDsen 22 
                 ++aDs+n
  EFC37325.1 725 LIADSNN 731
                 4677776 PP

  == domain 11  score: -3.5 bits;  conditional E-value: 8.3
                 SEEEEEE CS
         NHL   3 yPhGvav 9  
                 +P+Gva 
  EFC37325.1 792 NPRGVAS 798
                 7****96 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.6e-06    0.0042     115     212 ..      82     191 ..      65     200 .. 0.81
   2 ?    0.8   0.1      0.18     3e+02      26      79 ..     261     313 ..     229     483 .. 0.63
   3 !    6.8   0.3    0.0028       4.6     183     218 ..     549     590 ..     385     599 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.6e-06
         SGL 115 galyr.ldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge................gepDGlavDaeGn 196
                 g+l+r ld  + ++ +  ++  p  la+sp ++tlY++  l +k++++d+  +g+     + f d++ ++                ++p G+avD++G 
  EFC37325.1  82 GNLMRkLDLTTGMTYIFANVENPGLLAFSPNETTLYVCFPLSNKVQRMDFLPNGT-----EIFSDFAGNGnsgntgegglainaqlNQPSGVAVDSNGD 175
                 55554355557788888888888889************************65555.....77888877777889*********99977*********** PP

         SGL 197 vwvAvwgggkvvrfdp 212
                 v++   g+g +++++ 
  EFC37325.1 176 VYISDSGNGLIRKVSI 191
                 ****999999988775 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.18
         SGL  26 rldpatgketvldtpesvGaiaprkdgrlvvasksglalldlasgeletladee 79 
                  ++ ++g+ + +++++++ +i+  k +++ +  +++ ++ ++++g+++t+a +e
  EFC37325.1 261 GYSGDGGDAKLAKMKNPINVIVS-KTNEIFISDADNNVIRKVSNGNISTIAGNE 313
                 45556666666777777777777.777777777777777777777777777663 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0028
         SGL 183 e......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                        + p  +a+  +G+v++A wg++ ++++d++G +++
  EFC37325.1 549 LaissvlSSPSDVAIAPNGEVFIADWGNHVIRKIDTKGIITT 590
                 155555544556788899999999999999999999996655 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.2       7.5   1.2e+04      12      18 ..     388     394 ..     387     396 .. 0.69
   2 !   28.2   9.1   1.1e-09   1.8e-06       4      32 .]     729     756 ..     726     756 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 7.5
       EGF_2  12 GtCvnqc 18 
                 G+Cvn++
  EFC37325.1 388 GICVNEN 394
                 9997654 PP

  == domain 2  score: 28.2 bits;  conditional E-value: 1.1e-09
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++iC+g+G+C++++  C+C++gy+G++C
  EFC37325.1 729 SNNICSGNGSCISTN-TCQCKPGYTGAQC 756
                 389********9666.9************ PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.3     0.082   1.3e+02      12      28 ..       5      19 ..       2      19 .. 0.83
   2 !   19.6   6.6   5.3e-07   0.00087       3      31 ..     729     754 ..     728     755 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.082
                EEEETTTEEEEEECTTE CS
         EGF 12 CvdtgrggytCiCpeGy 28
                Cv++    ++CiC  G+
  EFC37325.1  5 CVTVV--LFYCICLLGF 19
                76667..89****9998 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 5.3e-07
                 STT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 +n+ Cs++G C++t     tC+C++GytG+
  EFC37325.1 729 SNNiCSGNGSCISTN----TCQCKPGYTGA 754
                 7999*******9999....**********6 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.4   9.7e-06     0.016      10      33 ..     159     183 ..     152     187 .. 0.81
   2 ?   -2.7   0.0       3.7   6.1e+03      23      29 ..     453     459 ..     452     459 .. 0.87
   3 ?   -3.8   0.0       8.2   1.3e+04       9      29 ..     552     572 ..     549     572 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 9.7e-06
        SBBP  10 gast.ygngIavDsnGNiYvtGsTn 33 
                 +a++ +++g+avDsnG +Y+  s n
  EFC37325.1 159 NAQLnQPSGVAVDSNGDVYISDSGN 183
                 667779*************975555 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3.7
        SBBP  23 nGNiYvt 29 
                 nG +Yv+
  EFC37325.1 453 NGDVYVA 459
                 9****97 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 8.2
        SBBP   9 pgastygngIavDsnGNiYvt 29 
                 ++   +++++a+ +nG ++++
  EFC37325.1 552 SSVLSSPSDVAIAPNGEVFIA 572
                 566668999999999988886 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.3      0.35   5.7e+02      14      22 .]      11      19 ..       2      19 .. 0.77
   2 ?   -2.7   0.1       6.8   1.1e+04       5      11 ..     388     394 ..     386     396 .. 0.70
   3 !   16.7   7.9   5.3e-06    0.0086       1      22 []     733     751 ..     733     751 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.35
                .-EE--TTX CS
        hEGF 14 ykCiCpPGy 22
                + CiC+ G+
  EFC37325.1 11 FYCICLLGF 19
                67****998 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 6.8
                 -EES..- CS
        hEGF   5 GtCidgv 11 
                 G+C++  
  EFC37325.1 388 GICVNEN 394
                 7999655 PP

  == domain 3  score: 16.7 bits;  conditional E-value: 5.3e-06
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G+Ci     ++C+C+PGy
  EFC37325.1 733 CSGNGSCI---STNTCQCKPGY 751
                 ********...558*******9 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       8.2   1.3e+04      41      74 ..      87     119 ..      81     128 .. 0.65
   2 ?   -0.3   0.0      0.75   1.2e+03       3      18 ..     168     182 ..     161     190 .. 0.83
   3 ?   -0.3   0.0      0.71   1.2e+03      57      80 ..     384     407 ..     373     414 .. 0.69
   4 ?    0.8   0.0      0.33   5.4e+02      54      85 ..     496     526 ..     493     530 .. 0.68
   5 ?    4.6   0.0     0.021        35      52      73 ..     608     629 ..     605     639 .. 0.88
   6 ?    1.1   0.0      0.26   4.2e+02      10      46 ..     667     703 ..     662     706 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 8.2
   Str_synth  41 kydkstkvvkvlldkLyfanGialsedgsfvlvc 74 
                 k+d +t  +  +  +   +  +a s++++ + vc
  EFC37325.1  87 KLDLTTGMT-YIFANVENPGLLAFSPNETTLYVC 119
                 466666666.666677777778888888888777 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.75
   Str_synth   3 ldvdeetgvlyftdsS 18 
                 + vd++ g +y++ds 
  EFC37325.1 168 VAVDSN-GDVYISDSG 182
                 678888.999999985 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.71
   Str_synth  57 yfanGialsedgsfvlvcetamkr 80 
                  ++ Gi + e+   ++++e     
  EFC37325.1 384 LYPKGICVNENTGDIIFSEAYGDT 407
                 567777777777777777766555 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.33
   Str_synth  54 dkLyfanGialsedgsfvlvcetamkrisryw 85 
                  kL  +n +++s+ ++ v +++t+ + i + +
  EFC37325.1 496 AKLNAPNSVKVSSSDEIV-IADTSNNVIRKVF 526
                 578889999998877655.4677766666655 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.021
   Str_synth  52 lldkLyfanGialsedgsfvlv 73 
                 l  +L+f+  i+ls+dg+ +++
  EFC37325.1 608 LTAQLKFPKSISLSKDGELFIS 629
                 6789*************99886 PP

  == domain 6  score: 1.1 bits;  conditional E-value: 0.26
   Str_synth  10 gvlyftdsSskydrrqvllallegdktGrllkydkst 46 
                  +  ftd  +  +  ++++ + +g  +G+++k+ k t
  EFC37325.1 667 TASVFTDQIHIMSNGDLIIGIGNGYDNGKIYKLSKLT 703
                 556799999999999*****************98765 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   8.5e-05      0.14     196     327 ..     107     251 ..      89     264 .. 0.74
   2 ?   -3.1   0.0       2.1   3.5e+03      88     117 ..     445     473 ..     435     514 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 8.5e-05
                 EEE-TTSSEEEEEETTTTEEEEEEEE-TTT.EEEEEEEEESS-TSS-S-.......--EEEEEE-TTSSEEEEEETS..........STEEEEEEE-TT CS
   Lactonase 196 laFhpdgkiaYvvnELsstvsvfsydeatg.aleelqtvstlpegftgk.......nsaaeIrlspdgkflyvSnRg..........adsiavfavdea 276
                 laF+p+++++Yv   Ls++v+ +++ +++   +++        ++ +g        n+++ +++ ++g  +y+S+ g          +  i+ fa +++
  EFC37325.1 107 LAFSPNETTLYVCFPLSNKVQRMDFLPNGTeIFSDFAGNGNSGNTGEGGlainaqlNQPSGVAVDSNG-DVYISDSGnglirkvsisSGIITKFAGTSQ 204
                 79*********************9997766444665555555444555488888899********999.56******8889988887777888887666 PP

                 T--EEEEEEEE-SSS.--EEEE-TTSSEEEEEETTTTEEEEEEEETTTTEE CS
   Lactonase 277 dgtltlveevstegkfPRdfaldpsgklllvanqksdnvtvferdaetGkL 327
                 +       + +++  +PR +++ p+g+l ++a+  sdn +v ++ + +G +
  EFC37325.1 205 GFAGDGGLAKNAKLSNPRGLNFGPNGDL-YIAD--SDNNVVRRI-NSSGII 251
                 5444555556677788999999999996.4444..444444444.345555 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 2.1
                 EEEEEE-TTSSEEEEEETTTTEEEEEEB.T CS
   Lactonase  88 pchlsvdedgkllavAnYsggsvsvfplda 117
                 p  ++ +++g  ++vA+Y ++ ++ ++ + 
  EFC37325.1 445 PSLIQCQPNGD-VYVADYFSNLIRLVSTNG 473
                 55666667766.788888888888766553 PP

>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   6.4   0.00017      0.28       3      32 ..     733     757 ..     722     761 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00017
                  CCTTTBCCSSEETTTECESBTTTEESTTS- CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCd 32 
                  C+++    +sC s t +C+Ck++++G +C+
   EFC37325.1 733 CSGN----GSCIS-TNTCQCKPGYTGAQCQ 757
                  3333....48887.9**************7 PP

>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1      0.29   4.8e+02       2      12 ..      11      21 ..      11      26 .. 0.89
   2 ?    8.3   3.8    0.0013       2.1       3      12 ..     744     753 ..     744     758 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.29
                EEEE-STTEEE CS
        cEGF  2 YrCsCppGYkl 12
                ++C C  G+ l
  EFC37325.1 11 FYCICLLGFLL 21
                89******976 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0013
                 EEE-STTEEE CS
        cEGF   3 rCsCppGYkl 12 
                 +C+C+pGY+ 
  EFC37325.1 744 TCQCKPGYTG 753
                 7*******94 PP

>> Peptidase_A3  Cauliflower mosaic virus peptidase (A3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1     0.052        84      46      77 ..     273     304 ..     267     318 .. 0.82
   2 ?    5.6   0.1    0.0061        10      46      73 ..     505     532 ..     495     541 .. 0.79
   3 ?   -3.1   0.0       2.8   4.6e+03      52      66 ..     568     582 ..     554     592 .. 0.68

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.052
  Peptidase_A3  46 ilkrPkevkiadkskitiskvikdvdlkienk 77 
                    +k+P++v+++   +i+is++ ++v  k+ n 
    EFC37325.1 273 KMKNPINVIVSKTNEIFISDADNNVIRKVSNG 304
                   67899999999999999999999998888764 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0061
  Peptidase_A3  46 ilkrPkevkiadkskitiskvikdvdlk 73 
                    +    e++iad s+  i+kv k+  ++
    EFC37325.1 505 KVSSSDEIVIADTSNNVIRKVFKNGTII 532
                   5566789****************96543 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.8
  Peptidase_A3  52 evkiadkskitiskv 66 
                   ev iad  ++ i+k+
    EFC37325.1 568 EVFIADWGNHVIRKI 582
                   677777777777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (821 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 4970.37
//
Query:       EFC37326.1  [L=316]
Description: hypothetical protein NAEGRDRAFT_81946 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.2   1.8        0.2   11.4   1.8    1.3  1  DUF4769   Domain of unknown function (DUF4769)


Domain annotation for each model (and alignments):
>> DUF4769  Domain of unknown function (DUF4769)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   1.8   1.1e-05       0.2      89     203 ..      17     139 ..       7     145 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 1.1e-05
     DUF4769  89 vaesessleeskkpeelvkd....lpaeplvslneevesssvleamqpllepsellstalvtlakeeekedadasedkgv...tvlgilqasgikaqsl 180
                 ++++e+ +++s+ p+++ ++    +  + + sl+++ + +s+ +++ p ++++ l+s +++t++ +e+  + + se ++       g+l +  i + s 
  EFC37326.1  17 QERMENRQVSSHAPQNSSSSssrlQLPSNVPSLTNSPQVNSISTVIIPSNNHQTLVSNNSSTNQANENPIQVVYSETNQQqfdDSQGLLGSFDISSDST 115
                 33444445555555544444223233456889******************************999998888776665544111568999********** PP

     DUF4769 181 lerlGqneeldavqrllli.qlic 203
                   + Gq +  + v+  lli  +ic
  EFC37326.1 116 SGKNGQSNIKSFVKAALLIfHIIC 139
                 *******99999998888735777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1306  (0.0728429); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 2142.48
//
Query:       EFC37327.1  [L=342]
Description: hypothetical protein NAEGRDRAFT_81947 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       426  (0.0237604); expected 358.6 (0.02)
Passed bias filter:                      259  (0.0144459); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 2343.27
//
Query:       EFC37328.1  [L=241]
Description: hypothetical protein NAEGRDRAFT_81948 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-39  136.5   3.8    2.3e-38  132.2   3.8    2.0  1  DUF3431   Protein of unknown function (DUF3431)


Domain annotation for each model (and alignments):
>> DUF3431  Protein of unknown function (DUF3431)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  132.2   3.8   1.3e-42   2.3e-38       2     202 ..       2     187 ..       1     201 [. 0.87

  Alignments for each domain:
  == domain 1  score: 132.2 bits;  conditional E-value: 1.3e-42
     DUF3431   2 VvaklkeedtsWveeelpdlqtaiYvvddpsaeltvpankGreamaYltyiidnYdsLpdvvvFvhahraawhndaldydnaallrrlrleavqeeGYv 100
                 +v +  +ed+sW++++lp++ +a+Y   +p+a + v +n+G+e  +Yl+yiid+Y++Lp+ +vFvh+hr awh      d++++l++l+  +     Yv
  EFC37328.1   2 IVVSKYTEDVSWLDTYLPHIPHAVYDRLNPQAPYIVHSNRGHEGSTYLKYIIDHYETLPENIVFVHGHRIAWHCR----DMVTILENLHWGKF---DYV 93 
                 45556789******************************************************************9....99999999998766...599 PP

     DUF3431 101 nlrckwepgCpaelkplekeeeekkeeealaeafaelfeee..evpevvaapcCaqFavsrerirkrpreeYvrlrqwlletelddelsGrvleylWhi 197
                 +l     +     l+      ++++   a+++ + +lfe++  ++p  ++  cCa F v  +rir++p++ Y rl +wl + e +++ s r++e++W +
  EFC37328.1  94 SLNPAYFQ----VLN------STSSDYLAVSKYWPRLFEDTlgQMPPLIKDWCCASFHVKGKRIRRHPKSFYLRLYEWLQSGEEENYWSSRIMEHVWVL 182
                 88763222....223......234556689999999998777799****************************************************** PP

     DUF3431 198 lFgke 202
                 +F ++
  EFC37328.1 183 MFASK 187
                 **664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       421  (0.0234815); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1473.17
//
Query:       EFC37329.1  [L=559]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        8.8    5.4  20.8         12    4.9  20.8    1.2  1  SOG2      RAM signalling pathway protein


Domain annotation for each model (and alignments):
>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9  20.8   0.00069        12     231     346 ..     405     530 ..     318     546 .. 0.52

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.00069
        SOG2 231 plrsd.qipfnl............srsrrssssgnsaspaangaqsetsersasssg.vqssasstPlgegstsp..p.galsrqslsttgststltss 312
                 pl s+ +++ n+            s++++ssss+ ++s+ +n+++++ +       + ++s+ ++t  ++g++s+  +  ++++++++ t+st  +++s
  EFC37329.1 405 PLDSSiTVTINGnakvsmnftvgtSATSASSSSNGGSSSGNNTNTNNGT-------ViNPSNGNNTNTNNGTSSNngTvITPTTSTVKPTTSTVVPKTS 496
                 5556666666666555433344442222222222222222222222222.......2233333333333333333224455555555556666555555 PP

        SOG2 313 sksrsssrsntnasastprslattpa...ppasaesf 346
                 s +++ss+sn   s+++p s+ ++ +     +sa+sf
  EFC37329.1 497 STNSGSSSSN---STTNPTSSGNSNRngtVISSANSF 530
                 5555444444...333344444333311112333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (559 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       956  (0.0533214); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.48
# Mc/sec: 3480.52
//
Query:       EFC37330.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-46  158.7   0.0    1.7e-46  158.4   0.0    1.1  1  RrnaAD           Ribosomal RNA adenine dimethylase
  ------ inclusion threshold ------
       0.08   13.7   0.0       0.26   12.0   0.0    1.9  2  Methyltransf_25  Methyltransferase domain
       0.11   12.0   0.1       0.75    9.3   0.1    2.2  2  Methyltransf_PK  AdoMet dependent proline di-methyltransferas


Domain annotation for each model (and alignments):
>> RrnaAD  Ribosomal RNA adenine dimethylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.4   0.0   2.9e-50   1.7e-46       3     237 ..       5     263 ..       3     283 .. 0.90

  Alignments for each domain:
  == domain 1  score: 158.4 bits;  conditional E-value: 2.9e-50
                 CCXXGCG--EE--HHHHHHHHHHH-GGTTSEEEEES-TTTCCHHHHHCC-.SEEEEE-S-HHHHHHHHCHTT..TCCCEEEE-S-CCGHHHHHHHCT.. CS
      RrnaAD   3 klrksygqnflknkkvineIldklnleekltvleigpGkGilTeeLakra.kqvvvlElderLakllqkkls..kdeklkvvhqDflkfetpeevte.. 96 
                 ++ k+++qnfl n  v ++I++      ++tv+eigpG+G lT+++++   k + v+E+der++  lq+  +  +d+k+ +v+ D+lk + ++ v +  
  EFC37330.1   5 QASKQLSQNFLLNLHVTDKIVRVCGDISNKTVIEIGPGPGCLTRSILQANpKRLIVVEKDERFMPALQNLQQsvDDGKMHIVQGDILKVDQFKLVDHfl 103
                 67799*****************99888899****************99999*****************9655999******************8777** PP

                 ........TTCCCCEEEEEEE--TTTHHHHHHHHHH.......GGGGCEE.EEEEEEEHHHHHHHH--TTSTT-SHHHHHHHHHEEEEEEEEC-GGCEC CS
      RrnaAD  97 ........kdsihqeflvvanlPyeistqlvkqlle.......esrfglv.kmllwlqkefarrllarpgskkrsrlsvlreaftdvklvakveksifs 179
                         +     +  +++nlP +i t+l   +l+       +  fg++  m+l++qke+  r+ a+ + k+ +rlsv ++ ++dv++   v++++f 
  EFC37330.1 104 ekdekvlkNSDELANVVFIGNLPFGIATPLLINWLKdcangtgAFAFGKKiPMVLMFQKEVGLRMSAKNSTKEFGRLSVSSQSVCDVEHMFVVNAKSFV 202
                 ****9886556667889************************88444443326*********************************************** PP

                 S--SSSEEEEEEEE-SS-S.--..S-HHHHHHHHHHHHCTTTSBCCCHCCCTSTCHHHHHC CS
      RrnaAD 180 Pppkvdsalvelerkdedl.pq..kdlkkyesvvrkllnrkrktlstslksllpggelqal 237
                 P pkvd ++++l++k+++l ++  ++ + +e+++r+++n krk+l+t+l+s ++ ++  ++
  EFC37330.1 203 PAPKVDASVMRLIPKTTPLiDNslVQFEDLEQFCRIIFNGKRKQLNTNLSSYFSPKQCAYI 263
                 *****************99866224667899***********************9998776 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   4.4e-05      0.26       1      59 [.      36      94 ..      36     109 .. 0.86
   2 ?   -3.0   0.0       2.1   1.3e+04      63      89 ..     276     301 ..     257     304 .. 0.59

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.4e-05
                     EEEET-TTSHHHHHHHCTSTSSEEEEEESSHHHHHHHHHHHHH.TTTTEEEEESBCCGBS CS
  Methyltransf_25  1 vLdlGcGtGrltlalakrlgkakvtgvDiseemleaareraee.eglnvefvqgdaedlp 59
                     v+++G G+G lt+ ++++   ++++ v+ +e+++ a ++  ++ ++ ++++vqgd+ +++
       EFC37330.1 36 VIEIGPGPGCLTRSILQAN-PKRLIVVEKDERFMPALQNLQQSvDDGKMHIVQGDILKVD 94
                     789***************5.7************99988888664444********98765 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.1
                      TTEEEEEEESTGGGSSHHHHHHHHHHH CS
  Methyltransf_25  63 gsfDlvvssgalhhlsdedlekalkei 89 
                      +s+++v+s+ + + l+ e++  + +++
       EFC37330.1 276 DSVNAVLSQRS-QDLTVEEITSMARRF 301
                      56666666433.445555666555555 PP

>> Methyltransf_PK  AdoMet dependent proline di-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.1   0.00013      0.75      38     100 ..      11      76 ..       4     127 .. 0.82
   2 ?   -2.7   0.0      0.56   3.3e+03     105     120 ..     190     205 ..     156     231 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00013
  Methyltransf_PK  38 srkflkklkkeslp....gkrevkvaldcGaGiGrvtknlLlkllskvDlvepvekflekakeelae 100
                      s++fl +l+   ++    g  ++k+++++G G G +t+++L    +++ +ve  e+f+ +++ +l +
       EFC37330.1  11 SQNFLLNLHVTDKIvrvcGDISNKTVIEIGPGPGCLTRSILQANPKRLIVVEKDERFMPALQ-NLQQ 76 
                      8899998877655545558999***********************99999999999998877.4444 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.56
  Methyltransf_PK 105 vgkvyvvglqeftPee 120
                      v +++vv  + f+P+ 
       EFC37330.1 190 VEHMFVVNAKSFVPAP 205
                      4556777777777763 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      563  (0.0314016); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 2006.79
//
Query:       EFC37331.1  [L=678]
Description: signal recognition particle receptor alpha subunit family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-55  187.8   0.6    1.6e-53  181.3   0.6    2.6  1  SRP54        SRP54-type protein, GTPase domain
    3.5e-35  122.4  30.5    5.7e-35  121.7  30.5    1.3  1  SRP-alpha_N  Signal recognition particle, alpha subunit, N-te
    1.8e-09   37.7   2.2    4.8e-09   36.3   0.1    2.8  2  SRP54_N      SRP54-type protein, helical bundle domain
    1.8e-05   23.9   0.0    0.00011   21.3   0.0    2.3  2  MeaB         Methylmalonyl Co-A mutase-associated GTPase MeaB
    3.2e-05   23.3   0.0    0.00014   21.2   0.0    2.1  1  Zeta_toxin   Zeta toxin
     0.0028   17.6   0.4       0.15   12.0   0.1    3.0  2  RsgA_GTPase  RsgA GTPase
     0.0028   17.9   0.1      0.013   15.8   0.0    2.2  2  AAA_22       AAA domain
     0.0037   17.3   1.7       0.05   13.7   0.2    3.3  2  CbiA         CobQ/CobB/MinD/ParA nucleotide binding domain
     0.0074   16.5   0.5       0.03   14.5   0.0    2.3  2  AAA_33       AAA domain
     0.0086   16.1   1.2       0.13   12.4   0.2    3.2  2  MMR_HSR1     50S ribosome-binding GTPase
  ------ inclusion threshold ------
      0.011   15.6   0.1        2.3    8.1   0.0    2.8  2  NTPase_1     NTPase
      0.017   15.5   0.8       0.12   12.7   0.0    2.9  3  AAA_19       AAA domain
       0.03   14.0   0.0      0.067   12.9   0.0    1.6  1  AAA_30       AAA domain
      0.037   13.8   0.2       0.51   10.1   0.0    2.5  2  CLP1_P       mRNA cleavage and polyadenylation factor CLP1 P-
      0.092   13.1   0.0       0.29   11.5   0.0    1.9  1  AAA_16       AAA ATPase domain
        0.1   12.2   0.4        9.8    5.7   0.0    3.1  2  AAA_25       AAA domain
       0.27   10.1  35.0       0.47    9.2  35.0    1.4  1  Mitofilin    Mitochondrial inner membrane protein
       0.41   11.1   0.0       0.41   11.1   0.0    2.8  2  AAA          ATPase family associated with various cellular a


Domain annotation for each model (and alignments):
>> SRP54  SRP54-type protein, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.3   0.6   1.6e-56   1.6e-53       2     195 ..     467     677 ..     466     678 .] 0.93

  Alignments for each domain:
  == domain 1  score: 181.3 bits;  conditional E-value: 1.6e-56
                 EEEEEEESTTSSHHHHHHHHHHHHHHTTS-EEEEEESTSSTTHHHHHHHHHHHTTEEEEESSTTSCHHHHHHHHHHHHHHTTSSEEEEEE--SSTTHHH CS
       SRP54   2 nvillvGlqGaGKTttlaKLaallkkegkkvllvaaDtfRaaAveQLktlaeklgvpvikkkeeadpaavakeavekakeekidvvlvDTaGrlqndke 100
                  vi+++G++G+GK ttl+K+  +l +++ ++l++a+DtfR +AveQL+++a+ l+vpv++k  ++++a++akea+++ak++++d+vlvDTaGr+q ++ 
  EFC37331.1 467 YVIVMCGVNGVGKSTTLSKICYWLLQKEFSCLIAACDTFRSGAVEQLQVHARCLNVPVFQKGYGKNAASLAKEAINHAKKNGFDIVLVDTAGRMQDNEP 565
                 79************************************************************************************************* PP

                 HHHHHHHHHHHHSSSEEEEEEETTBHTHHHHHHHHHHHHSS................CSEEEEESTTS.SSSTTHHHHHHHHHTS-EEEEE-SSSTTGE CS
       SRP54 101 lmeelkkikkvvkpdevllvldattgqeavkqakaFkeavg................itgviltklDg.dakgGaalsiaaelklPikfigvGekiedl 182
                 lm+ l ++ +v +pd vl+v +a++g++ + q ++F+++++                i+g++ltk+D+ d k Gaa+s++++++ Pi+f+gvG++++dl
  EFC37331.1 566 LMKSLIELIQVNTPDLVLFVGEALVGNDGIDQLQKFNSSLKvlassenaatkqtkdlIDGIVLTKFDTiDEKVGAAVSMVHKTGHPIVFVGVGQTYTDL 664
                 ************************************98876333344444445555579********8689**************************** PP

                 EE--HHHHHHHHH CS
       SRP54 183 eefdperlvsrll 195
                 ++ + e++v++ll
  EFC37331.1 665 RTLKVESVVKSLL 677
                 ***********98 PP

>> SRP-alpha_N  Signal recognition particle, alpha subunit, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  121.7  30.5   5.7e-38   5.7e-35       1     272 [.      26     334 ..      26     357 .. 0.59

  Alignments for each domain:
  == domain 1  score: 121.7 bits;  conditional E-value: 5.7e-38
                  HHHHHHHHHHTTT-SS-.----TTS---.-S--EEEEETTTTEEEEEE-BTTB--CHHHHHHHHHHHHHHHHHGGGGG.....SS-S----TT...HH CS
  SRP-alpha_N   1 spiNaLIrdvllEERsgaaasnssfkkd.sytLKwtfdnelgLvFVavYqkiLhLsYvDkLLdnvkteFvdlYkpklk.....pkttlvecaksy.Fd 91 
                  +piN+LIr+vllE+R ++    ++f+++ +y L w  +ne++L+FV+v+q  ++++++D LL+n+k  F++ +k+ l+      k+  v  ++++ Fd
   EFC37331.1  26 NPINELIRSVLLEDRLSD----KTFNYQnEYLLTWLQENEFDLIFVVVHQIAIQITFIDTLLENIKNKFTSTFKKVLQdakgkGKGMSVLSEHEFsFD 119
                  69*************988....99**9989*********************************************999766543333333334679** PP

                  HHHHHHHHHHXXXXXXXXX........XXX..XXXXXXXXXX.....XX.XX...........................XX.........XXXXX... CS
  SRP-alpha_N  92 eyFdqllrelEasaeaakkskaakepkamksfeeskkskktvksskedkkpe................gkkkkgakkekda.........sddstpsa 164
                  ++F+++l++lE++++++k+ +++      +++ +++ +kk +++++e++k++                +           +         +++++++a
   EFC37331.1 120 KEFTKILNNLEERSREEKQLQKEGLL--IRQYRKKDDEKKDESTNNEEEKKKttfiekqiqkgeemlqT-----------SspkqmskyeKKKDKKAA 204
                  ***************98776665433..34444444444444333433333233454444443444330...........133334444433333333 PP

                  XXXXXXXXXX.........XXXXXXX.XXX.XXXXXXXXXXXXXX..XXXXXXXXXXX....XXXXXXX........XXXXXX.XXXXXXXX...XXX CS
  SRP-alpha_N 165 tpetsrpstp.........sglltakeagptaedvsrrarkkankkrssagassgdeakasksskkkkkkp......kkkgkk.aRvWdadg...sad 243
                  tp+t + +++         +  ++a+e ++++++ +++ +k++ k ++ + a++g++++ ++ s ++ +++      k+k kk a  Wd+     +++
   EFC37331.1 205 TPTTTQIEESdseeeddeaQTPKSATEMNENVKANIEQMKKRFGKFKGVNMAKKGSKKNVTEPSTPEDENSiptvqmKEKPKKvATNWDQFDttyTKK 302
                  332222222233333333322333333444455555555566665544444555555544444433333334444449999999******94344556 PP

                  XXXXXXXXXXX..XXXXXX........XXXXXXXXXX CS
  SRP-alpha_N 244 eedkLDySapadesgaeae........aveavdastw 272
                  ++++ D+S+++++ +++          +    +++ +
   EFC37331.1 303 KAENIDFSKKTKTGDEN-GspeddlqrH----KEKYM 334
                  677*****997665555.2357644331....33322 PP

>> SRP54_N  SRP54-type protein, helical bundle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.3       3.4   3.4e+03      46      63 ..     124     141 ..     122     153 .. 0.73
   2 !   36.3   0.1   4.8e-12   4.8e-09       5      73 ..     368     435 ..     365     441 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 3.4
                 HHHHHHHHHHHCTTSS-H CS
     SRP54_N  46 klienvkkkavgekklkp 63 
                 k+++n++++  +ek+l++
  EFC37331.1 124 KILNNLEERSREEKQLQK 141
                 899999997777666654 PP

  == domain 2  score: 36.3 bits;  conditional E-value: 4.8e-12
                 HHHHHHHHCCSSCGHHHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHCTTSS-HHHHHHHHHHH CS
     SRP54_N   5 lnsalkklsgkskideedleealkeleeaLleaDVgvkvvkklienvkkkavgekklkpkqqvkkivkd 73 
                 +++++++l++++++++edl+ ++++ +++L++++V+ +++ +++++v ++ vg kkl + +++k+ v +
  EFC37331.1 368 FSTFFSNLTNGRTLTKEDLDPVMEDFKQSLMKKNVAQEIAVSICDSVSENLVG-KKLGTFSSIKSEVTK 435
                 67899************************************************.887777777666544 PP

>> MeaB  Methylmalonyl Co-A mutase-associated GTPase MeaB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       3.6   3.6e+03     203     226 ..      93     116 ..      58     145 .. 0.55
   2 !   21.3   0.0   1.1e-07   0.00011      23     136 ..     460     563 ..     439     581 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.6
                 B--EEEEEBCCCTBSHHHHHHHHH CS
        MeaB 203 WrpkvlktsavegeGidelvdaie 226
                    kvl+ +  +g+G+  l ++  
  EFC37331.1  93 TFKKVLQDAKGKGKGMSVLSEHEF 116
                 233455555555556555555444 PP

  == domain 2  score: 21.3 bits;  conditional E-value: 1.1e-07
                 GGG-S-SEEEEEEE-TTSSHHHHHHHHHHHHHCTT--EEEEEE------------------HCCCTSTTEEEEEE-----HHHHHHHHHHHHHHHHHTT CS
        MeaB  23 lakaGraqvvGltGvPGaGkstlvealglelrrrGkrvavlavDPsspftGGsilGDklRleelavdegvfiRslpsrGalGGlaaktrevvllleaaG 121
                 + + Gr  v+ + Gv G+Gkst+++++   l ++     + a D   +f  G++       e+l+v++     ++  +G    +a  ++e+++     G
  EFC37331.1 460 VREQGRPYVIVMCGVNGVGKSTTLSKICYWLLQKEFSCLIAACD---TFRSGAV-------EQLQVHARCLNVPVFQKGYGKNAASLAKEAINHAKKNG 548
                 4678******************************9999999988...6888886.......78888888888899999999999*************** PP

                 -SEEEEEEESSTTHH CS
        MeaB 122 fDvvlietvGvGqse 136
                 fD+vl++t G  q +
  EFC37331.1 549 FDIVLVDTAGRMQDN 563
                 **********88865 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   1.4e-07   0.00014       5     108 ..     454     562 ..     451     572 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 1.4e-07
  Zeta_toxin   5 lkdkk.ypsqerPklillgGqpGAGKselaellkdele.rqgnvvrldpDdlRelhPeyeeilkadpkkaseltq....kdaselvekllqeaiengyn 97 
                 lk+++ + +q rP +i++ G  G GKs++++++   l  ++ +++    D++R+    +e+++ +    ++ ++q    k a  l+++++++a +ng++
  EFC37331.1 454 LKEAStVREQGRPYVIVMCGVNGVGKSTTLSKICYWLLqKEFSCLIAACDTFRSGA--VEQLQVHARCLNVPVFQkgygKNAASLAKEAINHAKKNGFD 550
                 5555657788********************999887764888999999******98..55555555555555555111167899*************** PP

  Zeta_toxin  98 iiv.egtlrspd 108
                 i++ +++ r  d
  EFC37331.1 551 IVLvDTAGRMQD 562
                 985155555444 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.0   0.1   0.00015      0.15      65     119 ..     434     486 ..     385     494 .. 0.75
   2 ?    2.3   0.0      0.14   1.4e+02      50      86 ..     625     659 ..     606     674 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00015
                  HHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTTSEEEEECSTTSSHHHHHHHH CS
  RsgA_GTPase  65 leelkeelealgyevllvsaktkegleelkellkdktsvlvGqSGvGKStLinal 119
                  +++++e+l+++ ++  +++    +++++++e+ +  ++v++G  GvGKSt + ++
   EFC37331.1 434 TKAMEEALTRILTPSRTINIL--KEASTVREQGRPYVIVMCGVNGVGKSTTLSKI 486
                  445555555555555555555..778899999999***************98876 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.14
                  EEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTT CS
  RsgA_GTPase  50 vivlnKiDlleeeeeleelkeelealgyevllvsakt 86 
                   ivl+K D ++e+    +  + ++++g ++++v + +
   EFC37331.1 625 GIVLTKFDTIDEKV--GAAVSMVHKTGHPIVFVGVGQ 659
                  59********9987..888899999999999998763 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       8.9   8.9e+03      57      75 ..     122     141 ..      92     157 .. 0.66
   2 !   15.8   0.0   1.3e-05     0.013       5     115 ..     466     573 ..     461     597 .. 0.69

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 8.9
      AAA_22  57 lrellralglelka.erlss 75 
                 ++++l++l+++  + + l++
  EFC37331.1 122 FTKILNNLEERSREeKQLQK 141
                 56667777766555434444 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 1.3e-05
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaeeerpevv..fvtlpsstsskdl.lrellralglelkaerlsseellealeqalraravielliiDEa 100
                  +++v +G  G+GK+t+l ++ ++l +       + +++   ++   s+  ++l  ++ + ++ + +k+++++   l +   +++++ +   ++++D a
  EFC37331.1 466 PYVIVMCGVNGVGKSTTLSKICYWLLQK------EFSCLiaACDTFRSGAVEQLqVHARCLNVPVFQKGYGKNAASLAKEAINHAKKNGF-DIVLVDTA 557
                 6789*********************876......45555335555555555555555555555555555888888888666666666666.79999999 PP

      AAA_22 101 qhlr.seealeeLrsl 115
                  ++  +e +++ L +l
  EFC37331.1 558 GRMQdNEPLMKSLIEL 573
                 8885435555555444 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1       1.3   1.3e+03      61      97 ..     124     162 ..      60     189 .. 0.71
   2 !   13.7   0.2     5e-05      0.05       8      86 ..     475     633 ..     468     653 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.3
                 HHHHHHCHCHHHH....EEEEEEEEESS...-TTCHHHH CS
                 xxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxx RF
        CbiA  61 ellealgkkkall..lkiagvvlnrvdgeneetllkeal 97 
                 ++l++l ++ + +  l+  g+++  +++++ e++ ++  
  EFC37331.1 124 KILNNLEERSREEkqLQKEGLLIRQYRKKDDEKKDESTN 162
                 444555554444456888888888888775444433333 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 5e-05
                 TTSSHHHHHHHHHHHHHHTT--EEEEEEEESSCCCCHHTTEB-HHHH.................................................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................................................... RF
        CbiA   8 GGvGKTtlaanLaralarrglrVllvDaDpqannlaileglendiep.................................................... 54 
                  GvGK+t++ +++  l ++++  l   +D+ ++ +  +e+l+   ++                                                    
  EFC37331.1 475 NGVGKSTTLSKICYWLLQKEFSCLIAACDTFRSGA--VEQLQVHARClnvpvfqkgygknaaslakeainhakkngfdivlvdtagrmqdneplmksli 571
                 59***************************995543..34444444449999999999999999******************************999999 PP

                 .........................CCHCCCHHHHHHCHCHHHH.......EEEEEEEEESS CS
                 .........................xxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxx RF
        CbiA  55 .........................dlkrllellealgkkkall.....lkiagvvlnrvdg 86 
                                           l+++  +l++l  + + +      +i g+vl+++d 
  EFC37331.1 572 eliqvntpdlvlfvgealvgndgidQLQKFNSSLKVLASSENAAtkqtkDLIDGIVLTKFDT 633
                 9999***************9996664444444444444433333777779999999999996 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.3       3.2   3.2e+03      12      44 ..     169     200 ..     168     245 .. 0.60
   2 !   14.5   0.0     3e-05      0.03       1      77 [.     468     555 ..     468     585 .. 0.61

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 3.2
      AAA_33  12 Kstlaerllkklg.avllssdtlrrrlfgtdqqs 44 
                 K+t++e+ ++k   +   ss++ ++++++  +++
  EFC37331.1 169 KTTFIEKQIQKGEeMLQTSSPKQMSKYEK--KKD 200
                 89999999965444444444443333333..222 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 3e-05
      AAA_33   1 lvllvGlpGsGKstlaerl....lkklgavllss.dtlrrrlfgtdqqskt......dytrvldrlyqilnelarkalsagrnvilda 77 
                 +++++G++G+GKst + ++    l+k+  +l++  dt+r+  +++ q + +       ++   +++    +e ++ a + g++++l  
  EFC37331.1 468 VIVMCGVNGVGKSTTLSKIcywlLQKEFSCLIAAcDTFRSGAVEQLQVHARclnvpvFQKGYGKNAASLAKEAINHAKKNGFDIVLVD 555
                 89************99997555566666555443266666444433333334444443444445555555566666666666655544 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       2.1   2.1e+03      69     100 ..      55      86 ..      42     103 .. 0.62
   2 !   12.4   0.2   0.00013      0.13       2      93 ..     469     598 ..     468     624 .. 0.56

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 2.1
                 HHHHHHCTSEEEEEEETT.TTCSHHHHHHHHHH CS
    MMR_HSR1  69 aflaleeadlillvvdas.eeklkpldeeleel 100
                 ++l+ +e dli++vv  +   +++ +d  le++
  EFC37331.1  55 TWLQENEFDLIFVVVH-QiAIQITFIDTLLENI 86 
                 5666677899988887.3222344444444444 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 0.00013
                 EEEEESTTSSHHHHHHHHH..........TSTEEESSSTTSSSSEEEEEEE...ETTEE.............................EEEEECGGCSS CS
    MMR_HSR1   2 vaivGrpNvGKStLinalt..........gekaivsdkpgtTrdinegrvk...lkgke.............................ielvDtpGlie 58 
                 ++  G   vGKSt +++++              i++   +    +++ +v+   l   +                             i+lvDt+G + 
  EFC37331.1 469 IVMCGVNGVGKSTTLSKICywllqkefscL---IAACDTFRSGAVEQLQVHarcL---NvpvfqkgygknaaslakeainhakkngfdIVLVDTAGRM- 560
                 677899999999999999955544322220...3333334444444444432220...022222233333444555555555555555********44. PP

                 HHHHHHHHHHHHHHHHC..T.SEEEEEEETT..TTCSHHH CS
    MMR_HSR1  59 gaseekglgkaflalee..a.dlillvvdas..eeklkpl 93 
                   ++++ l k++ +l++  + dl+l+v +a   ++++++l
  EFC37331.1 561 --QDNEPLMKSLIELIQvnTpDLVLFVGEALvgNDGIDQL 598
                 ..45566777777766544359***999865664445444 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.0    0.0023       2.3       2      28 ..     469     495 ..     468     512 .. 0.85
   2 ?    4.5   0.0      0.03        29      81     133 ..     533     586 ..     514     619 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0023
                 EEEE--TTSSHHHHHHHHHHHH...GG CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlellkssgv 28 
                 +++ G  GvGK+T ++k++  l ++++
  EFC37331.1 469 IVMCGVNGVGKSTTLSKICYWLLQKEF 495
                 6789**************998877766 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.03
                 HHHHHHHHHHHHH.HHH-EEEE---STTGGG-HHHHHHHHHHHTTTSEEEEE-- CS
    NTPase_1  81 feelalealrkal.seadviviDEiGkmElkskkfkeaveevLksekpvlavih 133
                 + +la ea+++a  ++ d++++D  G+m  + + +k+ +e +  + + ++  + 
  EFC37331.1 533 AASLAKEAINHAKkNGFDIVLVDTAGRMQDNEPLMKSLIELIQVNTPDLVLFVG 586
                 566778888888778899**********99988888888766555555555554 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0         6     6e+03      77     102 ..     105     141 ..      40     147 .. 0.60
   2 ?   -1.4   0.1       2.8   2.7e+03      49      64 ..     223     238 ..     205     315 .. 0.78
   3 ?   12.7   0.0   0.00012      0.12      11     136 ..     467     586 ..     455     656 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 6
      AAA_19  77 l..........ldfddlltealelle.eaeeekklqe 102
                              fd++ t+ l+ le +++eek+lq+
  EFC37331.1 105 GkgmsvlseheFSFDKEFTKILNNLEeRSREEKQLQK 141
                 0333444444446666676666777643344555543 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.8
      AAA_19  49 aftgrAakelrerlaa 64 
                 a t ++a e++e+++a
  EFC37331.1 223 AQTPKSATEMNENVKA 238
                 5688999999998844 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 0.00012
      AAA_19  11 kvllvtaGpGtGKTrvlkhivallvelggvkpeeillvaftgrAakelrerlaalgae.........atTiHrlalldfddlltealelleeaeeekkl 100
                  v+++ +  G GK+++l +i+ +l++ +       ++ +f + A+++l+   + l+++         a            +    a e+++     +  
  EFC37331.1 467 YVIVMCGVNGVGKSTTLSKICYWLLQKEFS-CLIAACDTFRSGAVEQLQVHARCLNVPvfqkgygknA-----------AS---LAKEAIN-----HAK 545
                 456667779*****************9933.3333444677778888888777777774433332221...........11...1122222.....222 PP

      AAA_19 101 qeee.llivDE...fqdvdelqyrLlkallgek.kklllvG 136
                 ++++ +++vD    +qd ++l+++L++ +  ++ + +l+vG
  EFC37331.1 546 KNGFdIVLVDTagrMQDNEPLMKSLIELIQVNTpDLVLFVG 586
                 23444666764222455566777777666666655566666 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   6.7e-05     0.067      20     124 ..     468     587 ..     455     589 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 6.7e-05
      AAA_30  20 vavltGpAGtGKttalkalreaweaaggrviglAptgkaAkvLa...............eelgieastiakllkrlkgrarlepg.tllivDEagmv.. 100
                 v v+ G+ G GK+t+l+++   + +++++ +++A     + +++               ++ g +a+++ak   ++++    ++g ++++vD ag +  
  EFC37331.1 468 VIVMCGVNGVGKSTTLSKICYWLLQKEFSCLIAACDTFRSGAVEqlqvharclnvpvfqKGYGKNAASLAKEAINHAK----KNGfDIVLVDTAGRMqd 562
                 67889**************99999999999999877655554441225555555555545666677777776666654....4566*********8865 PP

      AAA_30 101 dtkqlaallkaaekag.akvilvGD 124
                 +   +++l++ ++ +    v++vG 
  EFC37331.1 563 NEPLMKSLIELIQVNTpDLVLFVGE 587
                 6678999999999865477888885 PP

>> CLP1_P  mRNA cleavage and polyadenylation factor CLP1 P-loop
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0       0.5     5e+02       2      31 ..     474     503 ..     473     508 .. 0.86
   2 ?   10.1   0.0   0.00051      0.51      89     168 ..     535     618 ..     527     623 .. 0.74

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.5
      CLP1_P   2 pkdsGKSTlarlLlNyalrkgrkpvyvDlD 31 
                  + +GKST    ++ ++l+k+ ++++  +D
  EFC37331.1 474 VNGVGKSTTLSKICYWLLQKEFSCLIAACD 503
                 5789***************99999887777 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00051
      CLP1_P  89 reveekleenkkakasgliIntpGwvkglg..aellleliealepdvvvvldqeellnelkrdlp..lskvkvvklpkspgvvq 168
                 + ++e ++  kk + ++++++t G +++    ++ l eli++  pd+v+++++    n+  ++l+   s++kv+ ++++ + +q
  EFC37331.1 535 SLAKEAINHAKKNGFDIVLVDTAGRMQDNEplMKSLIELIQVNTPDLVLFVGEALVGNDGIDQLQkfNSSLKVLASSENAATKQ 618
                 3344444555667999**********8753348*******************98888888888885556666666666555544 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00029      0.29      17      76 ..     459     520 ..     448     591 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00029
      AAA_16  17 ervrsgrpelvllsGesGvGKsslvrellralekdggiflrgkcdqlesa.ipysa.laqal 76 
                     +grp +++  G  GvGKs+ + ++   l ++++ +l + cd ++s+ ++ ++  a++l
  EFC37331.1 459 TVREQGRPYVIVMCGVNGVGKSTTLSKICYWLLQKEFSCLIAACDTFRSGaVEQLQvHARCL 520
                 44567888888888***************888888899999999999555322222244444 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.1      0.11   1.1e+02      35      57 ..     468     490 ..     463     574 .. 0.68
   2 ?    5.7   0.0    0.0098       9.8     156     191 ..     609     650 ..     595     651 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.11
      AAA_25  35 lallaGapgtGKttlaldlalav 57 
                 +++ +G  g+GK+t ++ +++ +
  EFC37331.1 468 VIVMCGVNGVGKSTTLSKICYWL 490
                 56677777777777777666544 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0098
      AAA_25 156 ggdensnsd.....v.galvealeriarrtgaavllvhHvgK 191
                 + +en++++     + g ++++++ i ++ gaav +vh +g+
  EFC37331.1 609 ASSENAATKqtkdlIdGIVLTKFDTIDEKVGAAVSMVHKTGH 650
                 446666665666655899********************9986 PP

>> Mitofilin  Mitochondrial inner membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2  35.0   0.00047      0.47      46     346 ..     125     442 ..      81     461 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00047
   Mitofilin  46 vvdylleedpplae............klkeisklqvsavsevtkeskepkeekkkeksekqssassevaeeeaeatkkaaeaka........qqpkseq 124
                 +++ l+e++ ++++            k+++ +k+ ++ ++e +k+ + ++++ +k ++  q+s +++ ++ e++++kkaa  ++        +++++e 
  EFC37331.1 125 ILNNLEERSREEKQlqkegllirqyrKKDDEKKDESTNNEEEKKKTTFIEKQIQKGEEMLQTSSPKQMSKYEKKKDKKAATPTTtqieesdsEEEDDEA 223
                 455555555444445556777777766666666666666666665555555555555555666666666666666666666655555533332222333 PP

   Mitofilin 125 ekekaleevlkealskaekataaakeakdeakkavkeavdklkeasdteeksrekardtaleaaeaaaek..eleklkevielakqseeeaakplldaa 221
                 +  k+++e+ +++ + +e+ +++  ++k  +  a k + ++++e+s   +  +++++   ++ +e+ ++   + ++  ++++++k ++++++k++++  
  EFC37331.1 224 QTPKSATEMNENVKANIEQMKKRFGKFK-GVNMAKKGSKKNVTEPS---TP-EDENSIPTVQMKEKPKKVatNWDQFDTTYTKKKAENIDFSKKTKTGD 317
                 3333333333333333333333332222.12222233333333333...22.22222223344444444445789999999999999999999988877 PP

   Mitofilin 222 eet.lekli..ehlkkveekvekaqslaklvekykelveeerevFq.qelesiipeiitnlkednkklskddlnsliahAkteidqlskelaelkkeee 316
                 e   +e+ +  +++k +++  +  +  a +   y +++eee+e+++     +i+   ++nl++    l k+dl+ +++++k+ + + +   +e+ ++  
  EFC37331.1 318 ENGsPEDDLqrHKEKYMPNPNQMTDIDADI---YDSSSEEEEEIDEkPKKGNIFSTFFSNLTNGRT-LTKEDLDPVMEDFKQSLMKKNV-AQEIAVSIC 411
                 666344444002333344444444444444...4444444444433045568999999***99999.*******************999.89******* PP

   Mitofilin 317 kkieralekqkee.lekqeealsarleeera 346
                   +++ l  +k+  ++  ++++ +++ee+++
  EFC37331.1 412 DSVSENLVGKKLGtFSSIKSEVTKAMEEALT 442
                 ***************************9986 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   1.0       3.1   3.1e+03      25      74 ..     171     221 ..     163     262 .. 0.59
   2 ?   11.1   0.0   0.00041      0.41       2      74 ..     470     564 ..     469     632 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 3.1
                 EEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTS.TSEEEEEETGGGHHHHH CS
         AAA  25 efleisgsellskyvgesekkirelfkeakeka.kpsilfiDEidalaksr 74 
                 +f+e +  +  ++++  s+k+++++ k+  +ka +p+   i+E d+  +++
  EFC37331.1 171 TFIEKQIQKGEEMLQTSSPKQMSKYEKKKDKKAaTPTTTQIEESDSEEEDD 221
                 455555555555556666666666666655555566666666666665555 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00041
                 EEESSTTSSHHHHHHHHHHHH...THEEEEEETTTCSSS....................STTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH CS
         AAA   2 llyGppGtGKTllakavakel...gvefleisgsellsk....................yvgesekkirelfkeakekakpsilfiDEidalaksr 74 
                 +++G  G+GK+++ + ++  l   ++++l   + +++s                     y +++++  +e +++ak++    i+++D + ++  ++
  EFC37331.1 470 VMCGVNGVGKSTTLSKICYWLlqkEFSCLIAACDTFRSGaveqlqvharclnvpvfqkgYGKNAASLAKEAINHAKKNG-FDIVLVDTAGRMQDNE 564
                 689***************9975443444444555555446777777777777777777799999999999999999997.9******998885544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (678 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3133  (0.174745); expected 358.6 (0.02)
Passed bias filter:                      670  (0.0373696); expected 358.6 (0.02)
Passed Vit filter:                       103  (0.00574488); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              18  [number of targets reported over threshold]
# CPU time: 1.01u 0.34s 00:00:01.35 Elapsed: 00:00:00.52
# Mc/sec: 3916.77
//
Query:       EFC37332.1  [L=645]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.3e-06   27.4   0.1    3.1e-05   23.7   0.0    2.6  2  UBA          UBA/TS-N domain
    0.00032   20.7   0.3     0.0011   19.0   0.3    1.9  1  HOIP-UBA     HOIP UBA domain pair
     0.0025   17.6   0.3        1.8    8.4   0.0    3.8  4  UBA_3        Fungal ubiquitin-associated domain
     0.0036   17.0   0.4        1.8    8.3   0.1    3.1  3  CUE          CUE domain
  ------ inclusion threshold ------
      0.015   15.1   0.0      0.067   13.0   0.0    2.1  1  UBA_4        UBA-like domain
       0.18   11.9   1.6       0.29   11.2   0.1    2.2  2  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
        5.1    5.2  15.7        7.9    4.5  15.7    1.2  1  SSP160       Special lobe-specific silk protein SSP160


Domain annotation for each model (and alignments):
>> UBA  UBA/TS-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0   1.2e-08   3.1e-05       3      33 ..     334     364 ..     332     366 .. 0.92
   2 ?   -0.0   0.1      0.33   8.6e+02       5      25 ..     468     488 ..     465     491 .. 0.81

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 1.2e-08
                 HHHHHHHHHTTS-HHHHHHHHHHTTTSHHHH CS
         UBA   3 eeaiqrLveMGFdreevveALratgnNeErA 33 
                 ++ i++ v MGF+  e+++AL  + +N+E A
  EFC37332.1 334 PTLIEQVVGMGFTYKEARKALKECQGNVENA 364
                 6779*************************88 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.33
                 HHHHHHHTTS-HHHHHHHHHH CS
         UBA   5 aiqrLveMGFdreevveALra 25 
                 ++ +L+ +GF+ + vv AL  
  EFC37332.1 468 QVYNLCMLGFEMQSVVFALKK 488
                 56678889******9999876 PP

>> HOIP-UBA  HOIP UBA domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.3   4.2e-07    0.0011      73     112 ..     345     385 ..     320     406 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 4.2e-07
    HOIP-UBA  73 lsraEakealleagGdvekAvkqclreRr.kKvkelaslgf 112
                 ++ +Ea++al+e++G+ve+A + ++++R+ +K +e+ + + 
  EFC37332.1 345 FTYKEARKALKECQGNVENALTAIIEKRElAKRREMEEFER 385
                 6789************************7467777766544 PP

>> UBA_3  Fungal ubiquitin-associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.34   8.7e+02      28      43 ..     221     236 ..     218     239 .. 0.90
   2 ?    3.7   0.0     0.021        55       8      25 ..     332     349 ..     326     358 .. 0.79
   3 !    8.4   0.0   0.00071       1.8       8      34 ..     464     490 ..     457     508 .. 0.86
   4 ?   -2.2   0.0       1.4   3.7e+03       8      18 ..     613     623 ..     612     624 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.34
                 HHHHHS--SS--SS-- CS
       UBA_3  28 evLkrLgiksldpedn 43 
                 e++k+L i  l++ dn
  EFC37332.1 221 EAFKKLPIELLSMIDN 236
                 89*******9999998 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.021
                 -SHHHHHHHHHHT--HHH CS
       UBA_3   8 idrdlVdefvsqGFekdk 25 
                 +d+ l+++ v +GF    
  EFC37332.1 332 LDPTLIEQVVGMGFTYKE 349
                 899***********7665 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.00071
                 -SHHHHHHHHHHT--HHHHHHHHHHS- CS
       UBA_3   8 idrdlVdefvsqGFekdkvievLkrLg 34 
                 +d + V ++   GFe + v+ +Lk+ +
  EFC37332.1 464 VDYEQVYNLCMLGFEMQSVVFALKKAQ 490
                 68899999****************965 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 1.4
                 -SHHHHHHHHH CS
       UBA_3   8 idrdlVdefvs 18 
                 id+++V+ f +
  EFC37332.1 613 IDEEIVESFYN 623
                 89*****9976 PP

>> CUE  CUE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       2.4     6e+03      22      30 ..     170     178 ..     169     178 .. 0.89
   2 !    5.5   0.0    0.0055        14      17      38 ..     347     368 ..     344     370 .. 0.79
   3 !    8.3   0.1   0.00071       1.8       4      30 ..     408     434 ..     405     443 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.4
                 HHHHHCTTT CS
         CUE  22 avLrasngn 30 
                 +vL+++ngn
  EFC37332.1 170 FVLEDQNGN 178
                 79******8 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0055
                 HHHHHHHHHHCTTTHHHHHHHH CS
         CUE  17 eevIravLrasngnvEatinaL 38 
                     r++L + +gnvE++  a+
  EFC37332.1 347 YKEARKALKECQGNVENALTAI 368
                 566799***********96665 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00071
                 HHHHHHHHSTTS-HHHHHHHHHHCTTT CS
         CUE   4 mletLkemFPdldeevIravLrasngn 30 
                  l+ L+++F +ldee+I+ +    +++
  EFC37332.1 408 LLKALHSVFSQLDEETIAEAIKMADND 434
                 5899**************998887776 PP

>> UBA_4  UBA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   2.6e-05     0.067      12      35 ..     344     367 ..     340     372 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.6e-05
       UBA_4  12 GadeekArqlLeannWdLerAisl 35 
                 G++  +Ar+ L+ +++++e+A+++
  EFC37332.1 344 GFTYKEARKALKECQGNVENALTA 367
                 77999****************986 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   0.00012      0.29      21      74 ..      20      74 ..       9     109 .. 0.80
   2 ?   -2.6   0.1       2.3   5.8e+03      63     100 ..     351     384 ..     346     394 .. 0.45

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00012
                 ETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-.TTSBCCCCS-TTT CS
  Rad60-SLD_2 21 sdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLe.nnktlkelrlplg 74
                 + + tv + +e ++++  +   + +    ++ +i+ Gk+L+ +  tl++++++++
   EFC37332.1 20 DTSLTVLKFRELIVENHNQALPSDVWLLSEVTIINGGKFLKnDDETLADAKVKAS 74
                 4567888888999999999999999999************98899****998765 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.3
                  TSBCCCCS-TTTTTTTS-EEEEEEE---SS----.XX.X CS
  Rad60-SLD_2  63 nktlkelrlplgevkggvtvmHvvvrenlsekksekk.a 100
                   k+lke++  + +      +  ++ +++l+++++ ++ +
   EFC37332.1 351 RKALKECQGNVENA----LT-AIIEKRELAKRREMEEfE 384
                  56777775444444....22.233334444444333332 PP

>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5  15.7    0.0031       7.9     281     319 ..      83     123 ..      67     130 .. 0.68

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0031
      SSP160 281 asanstssststststtt..ststtttnsttstnstsssns 319
                  ++ s++sstst+++t t  sts+ t n  ++tnst   ns
  EFC37332.1  83 PASSSAASSTSTTATTITsnSTSSNTVNNNSTTNSTVGNNS 123
                 34455666666666655500555578999999999999988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (645 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2013  (0.112276); expected 358.6 (0.02)
Passed bias filter:                      624  (0.0348039); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.73u 0.37s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 3730.65
//
Query:       EFC37333.1  [L=445]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      8e-23   80.7   0.0      2e-22   79.5   0.0    1.7  1  Methyltransf_FA  Farnesoic acid 0-methyl transferase
  ------ inclusion threshold ------
      0.087   12.8   0.7        4.4    7.3   0.4    2.7  2  Cytokin_check_N  Cdc14 phosphatase binding protein N-terminus


Domain annotation for each model (and alignments):
>> Methyltransf_FA  Farnesoic acid 0-methyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5   0.0   2.2e-26     2e-22       1     101 [.      28     128 ..      28     129 .. 0.93

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 2.2e-26
  Methyltransf_FA   1 HiaLsseeypydsdemyeIviGgwgNtksairrqkrgnevvevstpgllsedefrkfwisw.tkdGlievgkg...geeepflewsdskplsvn 90 
                      Hi L++++    +++myeIviGgwgN +s+irr+ +g    ++  ++ +++d+f ++w+ + ++ G i++g g   ge + f+  sds+ l+v+
       EFC37333.1  28 HISLATSPLV--TSPMYEIVIGGWGNGQSVIRREAQGG-AWASIGHHPCNPDQFLDYWVCLnSDSGCISCGAGktvGE-QQFMILSDSNVLNVK 117
                      8999997777..*************************4.69999*****************8789********87666.*************** PP

  Methyltransf_FA  91 yigfstwgstg 101
                      ++gf+tw++++
       EFC37333.1 118 CVGFTTWDKPI 128
                      ********986 PP

>> Cytokin_check_N  Cdc14 phosphatase binding protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.018   1.6e+02      29      48 ..       8      27 ..       5      31 .. 0.91
   2 ?    7.3   0.4   0.00049       4.4      33      57 ..     359     383 ..     348     392 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.018
  Cytokin_check_N 29 YPdeeeleIlslqdenecDL 48
                     +Pd+++l+I+++q + + D+
       EFC37333.1  8 FPDDNPLKIVTFQAKAQNDI 27
                     89*************99997 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.00049
  Cytokin_check_N  33 eeleIlslqdenecDLDpdflvkdv 57 
                      +++++ +l d  ++D+ +df v+ v
       EFC37333.1 359 NDPDVNQLTDYFKYDMSRDFFVQKV 383
                      68899*****************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       664  (0.037035); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2738.14
//
Query:       EFC37334.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        4.4    7.2  12.8        5.2    7.0  12.8    1.0  1  TFIIA     Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0  12.8   0.00029       5.2      85     245 ..      19     170 ..       3     182 .. 0.53

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00029
       TFIIA  85 stsqslpslvipagksvqslt.anssaataatfslpakleppvqipagvtlqtasg..qlykvnvqasgaqqiaaqplqqvvqqsqgsaaqssvaalqa 180
                 s+ + + + +ip++  v+++  ++   +t+a++ l  +++  + + a ++l +++   +ly+   q +++++ia++p+ q+     +  + ++++++++
  EFC37334.1  19 SSYNDNWQPCIPDPVIVPQQRnQQYLVSTSAANGLS-NNDEFLSMFATLQLDSQEKliRLYTLIFQLQQQANIATSPAYQQ----DKVSTDETIPPVSS 112
                 444555556677776776666444444445555555.3344466666666666555668888888**************99....66666667777776 PP

       TFIIA 181 qsqqaqalaepqqq.lekq....qqqqqqqqqqqqqqqvqqqqqeesqqaqqasqeqvagsqvessqtdg 245
                  sq+  ++ e+++   + +          ++  q+++qv+++  ++s+ ++q++q+  ++      q+++
  EFC37334.1 113 ISQN-PQTNESSTStFS-ScfttS----TSPIIQHSNQVSSKITKPSKMKNQNPQKLSKP------QKSQ 170
                 6333.333333333233.223331....34444444444444443333333332221111......1111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1269  (0.0707792); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 1086.73
//
Query:       EFC37335.1  [L=295]
Description: hypothetical protein NAEGRDRAFT_53783 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.073   13.0   0.1        0.5   10.3   0.0    2.1  2  F-box_4       F-box
      0.099   12.8   1.0        0.2   11.8   1.0    1.5  1  NOB1_Zn_bind  Nin one binding (NOB1) Zn-ribbon like
       0.14   12.2   0.0         11    6.0   0.0    2.3  2  DUF4577       Domain of unknown function (DUF4577)
       0.19   11.9   0.0       0.32   11.2   0.0    1.3  1  PknG_rubred   Protein kinase G rubredoxin domain


Domain annotation for each model (and alignments):
>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   0.00011       0.5       4      37 ..      36      69 ..      33     124 .. 0.86
   2 ?    0.6   0.0      0.11   4.8e+02      78     112 ..     142     176 ..      97     179 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00011
     F-box_4  4 sLssLPlevlqhiaslLDsfsLsqLslvskllre 37
                +L+++P+e+l  ia+ L    +++Ls+v++ + +
  EFC37335.1 36 QLEDFPFELLISIATHLNGKDIYSLSKVNSVFLK 69
                7999***********************9987655 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.11
     F-box_4  78 fskvksWkfedvsslseHLkk.Cpfyererktepva 112
                    vk+W +   ++++ HL++  p+y   +k+ep++
  EFC37335.1 142 GLDVKNWMHLLRRRIA-HLQVnSPHYLPLTKHEPIK 176
                 4578999887777775.8886699999999999986 PP

>> NOB1_Zn_bind  Nin one binding (NOB1) Zn-ribbon like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.0   4.5e-05       0.2       6      32 ..     218     246 ..     215     265 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.5e-05
  NOB1_Zn_bind   6 swvlrChaCfkvt..kdmtkkFCpkCGnk 32 
                   +wv++C   +  +   d +k+FC +CG++
    EFC37335.1 218 EWVYKCPMDYDSMieDDPEKRFCTNCGKH 246
                   69999998888554477**********87 PP

>> DUF4577  Domain of unknown function (DUF4577)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0    0.0025        11     102     121 ..      53      72 ..      46      79 .. 0.82
   2 ?    3.8   0.0     0.013        57      14      46 ..     203     235 ..     198     253 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0025
     DUF4577 102 egkdidelkkinsmivkrln 121
                 +gkdi  l k+ns+ +k l 
  EFC37335.1  53 NGKDIYSLSKVNSVFLKLLF 72 
                 79**************9873 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.013
     DUF4577  14 hedrklyvvdsindlnklnlcpagsqhllplee 46 
                  e+r+ y +d i++ + +  cp++   +++ + 
  EFC37335.1 203 MEERNPYEIDGIENCEWVYKCPMDYDSMIEDDP 235
                 699*********************999997653 PP

>> PknG_rubred  Protein kinase G rubredoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   7.1e-05      0.32      91     109 ..     236     254 ..     228     268 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 7.1e-05
                  GG-B-TTT--B-S---SS- CS
  PknG_rubred  91 skRfCwrCGrpvGRseker 109
                   kRfC++CG+ v +  ++ 
   EFC37335.1 236 EKRFCTNCGKHVYKVYSQD 254
                  69*********98755444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       578  (0.0322383); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 2067.62
//
Query:       EFC37336.1  [L=252]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-21   75.9   0.1    7.3e-21   74.5   0.1    1.8  1  SUI1      Translation initiation factor SUI1


Domain annotation for each model (and alignments):
>> SUI1  Translation initiation factor SUI1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.5   0.1   4.1e-25   7.3e-21       3      76 ..     139     220 ..     137     221 .. 0.96

  Alignments for each domain:
  == domain 1  score: 74.5 bits;  conditional E-value: 4.1e-25
        SUI1   3 pkihirleqrggrKkvTtvsgleafgid........lkklakelkkkfacsgsvvkdggeeiqvQGdqrkkvaelLtekygv 76 
                 +++ ir+++r++rK++T+++g+eaf  d        +k+++k + kkfac++s+vk+++  i++QG++  kva+++t++ gv
  EFC37336.1 139 RELLIRIDKRSKRKRLTLITGIEAFMEDafrgdekfFKDVVKIFGKKFACGCSIVKKPELSIEIQGNVPGKVAKYFTKELGV 220
                 6788******************************************************9********************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (252 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1762  (0.0982765); expected 358.6 (0.02)
Passed bias filter:                      654  (0.0364772); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 1571.36
//
Query:       EFC37337.1  [L=167]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-14   53.3   0.0    3.4e-14   52.8   0.0    1.3  1  MAPEG     MAPEG family


Domain annotation for each model (and alignments):
>> MAPEG  MAPEG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.8   0.0   1.9e-18   3.4e-14      16     126 ..      51     161 ..      22     164 .. 0.80

  Alignments for each domain:
  == domain 1  score: 52.8 bits;  conditional E-value: 1.9e-18
                 HHHHHHHHHHTT--SS---S......SH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.....T-....HHHHHHHHHHHHHHHHHHHHHHHH-.. CS
       MAPEG  16 slivvkerrkakiaigegkanapralddklppklqrairahgNflEyvplfllavllaelt....gae....tglaallaaafvvaRvlhalgyiaggp 106
                 ++i+++er+++       k +   ++ ++++  ++r  r h+N++E+  +f+ a+ ++ l      a+    +++a+ l+ ++ +aR++++++y  g +
  EFC37337.1  51 GVIMGGERQAQLS-----KEQ--IDQINNPNSLVNRTLRIHRNDIENSLPFVSAAGVMVLLclvqDASdektQWIANSLMYSYSIARFVYVYAYWNG-K 141
                 5566666665544.....322..2344445779**************9999866555555522224434567************************9.* PP

                 SGGGHHHHHHHHHHHHHHHH CS
       MAPEG 107 ppgRslgflltllvllvlsl 126
                 +p Rs++++l++l+++++++
  EFC37337.1 142 QPHRSISWILGFLTTAGILG 161
                 ***************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1054.35
//
Query:       EFC37338.1  [L=327]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00025   20.5   0.1        4.6    6.5   0.0    3.2  3  MRJP          Major royal jelly protein
  ------ inclusion threshold ------
      0.027   14.0   0.0        7.2    6.1   0.0    2.3  2  SGL           SMP-30/Gluconolactonase/LRE-like region
        0.1   12.8   1.5       0.54   10.5   0.0    2.7  3  Arylesterase  Arylesterase
       0.67   10.3   3.1        3.4    8.0   0.2    3.4  4  NUMOD1        NUMOD1 domain


Domain annotation for each model (and alignments):
>> MRJP  Major royal jelly protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.0    0.0036        16      33      57 ..      87     111 ..      78     124 .. 0.85
   2 !    6.5   0.0     0.001       4.6      74      98 ..     172     195 ..     156     212 .. 0.82
   3 !    5.7   0.0    0.0018       8.2      78     102 ..     268     293 ..     229     319 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0036
        MRJP  33 pkllvfdlatdkllkrvelpadvak 57 
                 ++++vfd +t k++k+++l+ +v +
  EFC37338.1  87 NSIHVFDYTTKKHVKSIKLDVEVHE 111
                 68*****************987765 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.001
        MRJP  74 cddtfvYiaDakgkgliVYdladdk 98 
                  d+tfvY+ D +  gl+V+d+++++
  EFC37338.1 172 QDETFVYVMDYG-SGLMVFDSRTGQ 195
                 357*******98.9******99875 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0018
        MRJP  78 fvYiaDakgkgliVYdlad.dkswRv 102
                  +Y++D++gk++ V+d+ +  + +R 
  EFC37338.1 268 RIYVTDTVGKSITVFDMHTlTRVFRH 293
                 58999999999999987542445554 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0    0.0016       7.2       7      60 ..     170     224 ..     164     244 .. 0.75
   2 ?    4.6   0.0    0.0045        20     146     193 ..     267     309 ..     256     324 .. 0.59

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0016
         SGL   7 wdeeegaLlwvDilgqrihrldpatgketvldtpe.svGaiap.rkdgrlvvasks 60 
                  ++ ++++++v  +g+ ++ +d++tg+++++++p   +G+ +  +++++++++s++
  EFC37338.1 170 ECQ-DETFVYVMDYGSGLMVFDSRTGQRVHHKVPTvANGYGVAfTPENEMIITSAH 224
                 555.4455555556999******************955555553488999999987 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0045
         SGL 146 ktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkgegepDGlavDa 193
                 + +Y++D++ ++i+++d+ + +  +  r+ f  +++++     G+++D 
  EFC37338.1 267 QRIYVTDTVGKSITVFDMHTLTR-V-FRHEFpSNMPQYY----GIMIDR 309
                 56788888888888888754433.2.2222223333332....555555 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.2       2.7   1.2e+04      61      81 ..      74      92 ..      71     100 .. 0.54
   2 ?   10.5   0.0   0.00012      0.54      45      84 ..     246     285 ..     217     287 .. 0.89
   3 ?    0.0   0.0      0.22   9.9e+02      58      74 ..     304     320 ..     297     324 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.7
  Arylesterase 61 idadkkyiyvadilresihvm 81
                  i+ ++ yi ++ +  +sihv+
    EFC37338.1 74 ISYEHNYIIMGGM--NSIHVF 92
                  5556666666655..444443 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00012
  Arylesterase  45 evkvvasglssanGInidadkkyiyvadilresihvmkkh 84 
                   ++   +++ s++ G+ ++   + iyv+d + +si v++ h
    EFC37338.1 246 KNCLRIESDSTPYGVFYEVPTQRIYVTDTVGKSITVFDMH 285
                   55667888899***********************999887 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.22
  Arylesterase  58 GInidadkkyiyvadil 74 
                   GI id +  ++y+ d++
    EFC37338.1 304 GIMIDRKTGILYLPDVT 320
                   9***********99987 PP

>> NUMOD1  NUMOD1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.24   1.1e+03       3      12 ..      89      98 ..      88     104 .. 0.79
   2 ?   -3.4   0.0       2.9   1.3e+04      27      37 .]     113     123 ..     112     123 .. 0.82
   3 ?   -1.3   0.0      0.64   2.9e+03       2      12 ..     229     239 ..     229     246 .. 0.83
   4 ?    8.0   0.2   0.00077       3.4       3      17 ..     269     283 ..     268     283 .. 0.94

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.24
      NUMOD1  3 VyvYDlntkt 12
                + v+D++tk+
  EFC37338.1 89 IHVFDYTTKK 98
                669*****98 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.9
      NUMOD1  27 gishntInkyl 37 
                  i++n  n yl
  EFC37338.1 113 EIDKNGLNLYL 123
                 68999999997 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.64
      NUMOD1   2 pVyvYDlntkt 12 
                 pV++Y+ + k+
  EFC37338.1 229 PVEIYTFDEKK 239
                 89***988876 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.00077
      NUMOD1   3 VyvYDlntktigkFs 17 
                 +yv+D+ +k+i++F+
  EFC37338.1 269 IYVTDTVGKSITVFD 283
                 9*************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (327 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       581  (0.0324056); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 2203.31
//
Query:       EFC37339.1  [L=821]
Description: rhoGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.5e-46  156.7   4.3    7.5e-46  156.7   4.3    3.5  3  RhoGEF        RhoGEF domain
  ------ inclusion threshold ------
      0.015   15.6   0.6      0.089   13.1   0.6    2.3  1  Chromo_2      Chromatin organization modifier domain 2
      0.022   14.6   0.0      0.046   13.6   0.0    1.5  1  SH3_9         Variant SH3 domain
      0.036   13.7   0.0      0.076   12.6   0.0    1.6  1  SH3_1         SH3 domain
       0.21   10.9   0.5        2.6    7.3   0.3    2.5  2  LIP           Secretory lipase
        5.7    7.5   8.6       0.29   11.7   0.2    3.2  4  PH            PH domain


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   3.6       5.8   1.7e+04      60      60 ..     212     212 ..      75     289 .. 0.59
   2 !  156.7   4.3   2.5e-49   7.5e-46       2     182 .]     292     473 ..     291     473 .. 0.95
   3 ?   -6.4   7.5         6   1.8e+04     135     135 ..     729     729 ..     558     810 .. 0.57

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 5.8
                 H CS
      RhoGEF  60 L 60 
                 L
  EFC37339.1 212 L 212
                 1 PP

  == domain 2  score: 156.7 bits;  conditional E-value: 2.5e-49
                 HHHHHHHHHHHHHHHHHHHHHTHCCCHHCT.....CCHHHHHHHHCTTHHHHHHHHHHHHHHHHHHHH.HHHTTSS-S-SHHHHHHHHSTHHHHHHHHH CS
      RhoGEF   2 ikElleTErsYvrdLkvlvevylkplsele.....vlseeeikiiFsnieeilelhrsflleeLeerlkeseeqkeaqsigdvflkfadkfkkYseYcs 95 
                 ikE ++TEr+Yv+ Lk  +++++ p+ + +     +l++e  +++Fsnie+i++++ + ll++ e+ +   + +   ++ig+ f ++++ +k Y+ Y++
  EFC37339.1 292 IKETIDTERTYVNLLKAFIDIFYYPIVNDSghgkgILKKEVYNTLFSNIEQIYKIN-NTLLHDWENEY---NTNYPFVNIGKAFSQISPFLKAYTIYIN 386
                 89*********************777766679************************.88899787777...5677799********************* PP

                 CHHHHHHHHHHHHHHHHHHHHHHHHHHTSGGGTT--HHHHTTHHHHHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHHHHH CS
      RhoGEF  96 nypnalkllkelskknkkfkafleeaeerpecskldLeslLikPvqRlprYpLLLkellkntpeshpdyealkkaleaikevaseiN 182
                 n+++a++++++l++k+k+fk++l+e+ +++ +++  L  +Li PvqR+prY+LL++e+lkntp++h++ye l+k+ ++i+++a  +N
  EFC37339.1 387 NFDKAQEMFEKLREKDKRFKEYLTECYKNKLVKGTLLGGFLILPVQRIPRYKLLIQEMLKNTPPTHHEYEILQKCAKEIESIAAFVN 473
                 ***********************************************************************************9998 PP

  == domain 3  score: -6.4 bits;  conditional E-value: 6
                 H CS
      RhoGEF 135 l 135
                 +
  EFC37339.1 729 Y 729
                 2 PP

>> Chromo_2  Chromatin organization modifier domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.6     3e-05     0.089      28      64 ..     465     501 ..     453     503 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3e-05
    Chromo_2  28 vegseeeedeepeeleelltTiEpqelvqkaYPelve 64 
                 +e++ ++ ++e+ ++e+  t +E q++vqk YP+ v+
  EFC37339.1 465 IESIAAFVNDEKRNVEQNQTVFEVQNMVQKQYPQFVQ 501
                 4446788899999**999***************9986 PP

>> SH3_9  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   1.5e-05     0.046      14      44 ..       2      33 ..       1      35 [. 0.92

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.5e-05
       SH3_9 14 sLqrGDvitvieesedgWlegsl.tGrtGlvP 44
                s+ +GDv+ v +++ dgW  + l + +tG +P
  EFC37339.1  2 SVKAGDVVEVVKRYKDGWSWCYLkSRSTGTFP 33
                7889******************9788*****9 PP

>> SH3_1  SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   2.6e-05     0.076      14      48 .]       1      34 [.       1      34 [. 0.91

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.6e-05
                XEBSTTEEEEEEEECSSSEEEEEETTSTEEEEEEG CS
       SH3_1 14 LsfkkGDviivleksedgWwkgrlkgtgkeGliPs 48
                +s k GDv++v+++ +dgW  + lk++  +G +P+
  EFC37339.1  1 MSVKAGDVVEVVKRYKDGWSWCYLKSR-STGTFPT 34
                5899***************99999986.79*9995 PP

>> LIP  Secretory lipase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.3   0.00088       2.6     184     237 ..     173     228 ..     157     257 .. 0.87
   2 ?    0.5   0.0       0.1     3e+02     116     151 ..     634     669 ..     632     699 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00088
         LIP 184 krafekgsdvlkdetikkv..lednklsksavPqiPvlvyhgvidelipikdakkl 237
                 +  f++ s+++++e+i+kv  +e++k+s+   P+ P+ v++ v  ++i  ++++k 
  EFC37339.1 173 HESFKTSSSIITEEKIEKVekIEKTKISNVINPTFPIDVLNDVKKKVITKTETTKR 228
                 56799***********9975588888999999***********9999998887775 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.1
         LIP 116 vaeavdgtvfaGlialalnglaneypelkkilkeev 151
                 ++++++ ++f+ +i   + g++ ey  + + l+e+ 
  EFC37339.1 634 IFKRIEHEDFSFVIEALFKGVKTEYSFMTSNLNEKK 669
                 7999*********************99999888764 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.3   3.8e+03      17      37 ..      18      48 ..       3     104 .. 0.45
   2 ?   -2.4   0.3       2.3   6.8e+03      39      61 ..     222     247 ..     212     284 .. 0.57
   3 ?   11.7   0.2   9.7e-05      0.29      64     104 ..     639     679 ..     607     680 .. 0.79
   4 ?   -3.4   0.1       4.8   1.4e+04      66      94 ..     745     772 ..     725     774 .. 0.65

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.3
                SEEEEEEEEETTEEEEESST............T CS
          PH 17 swkkrwfvLkdsellyyknd............k 37
                +w   w++Lk+ +   +  d            +
  EFC37339.1 18 GWS--WCYLKSRSTGTFPTDspygmiptayltE 48
                566..7777776655555552333333333222 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.3
                 TTESSEEEEEESTTEEEEEEEC...T CS
          PH  39 ekdkepkgsislsncevvevva...t 61 
                 +++ ++++sis +  + +++ +   +
  EFC37339.1 222 KTETTKRESISFNLFSRQKRSKrhnH 247
                 56777888888888888875444331 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 9.7e-05
                 SSSTSEEEEEESTSSSTEEEEEEESSHHHHHHHHHHHHHHH CS
          PH  64 pkrkfcfelriverngsrtyllqasseeerkeWikaiqsai 104
                 + ++f+f++    ++ +++y + +s+  e+k+W+k+i++++
  EFC37339.1 639 EHEDFSFVIEALFKGVKTEYSFMTSNLNEKKAWMKSIRDCL 679
                 556777777433224479********************986 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 4.8
                 STSEEEEEESTSSSTEEEEEEESSHHHHH CS
          PH  66 rkfcfelriverngsrtyllqasseeerk 94 
                 +k + e+ i++ ++ +++ l+a++ +e+k
  EFC37339.1 745 TKLQKEIEIYNLDR-DQVMLEAKTLQEKK 772
                 44455566666666.77777777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (821 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2412  (0.134531); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.91u 0.33s 00:00:01.24 Elapsed: 00:00:00.56
# Mc/sec: 4418.00
//
Query:       EFC37340.1  [L=473]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-55  188.7   2.0    1.9e-54  184.9   1.2    2.0  2  HSP70     Hsp70 protein
    5.6e-13   48.4   0.6    2.3e-12   46.4   0.6    1.9  1  MreB_Mbl  MreB/Mbl protein
    6.8e-06   24.9   0.5       0.01   14.5   0.1    2.3  2  Actin     Actin
     0.0054   15.8   0.1       0.87    8.5   0.0    2.3  2  PilM_2    Type IV pilus assembly protein PilM;


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.4   0.0    0.0075        34       1      17 [.      40      56 ..      40      61 .. 0.86
   2 !  184.9   1.2   4.3e-58   1.9e-54      18     376 ..      94     463 ..      81     470 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.0075
                EEEEEEXSSEEEEEEEE CS
       HSP70  1 viGiDLGttnsvvavme 17
                +iGiD G+ n+ va ++
  EFC37340.1 40 AIGIDFGNHNCTVAYFN 56
                59***********9776 PP

  == domain 2  score: 184.9 bits;  conditional E-value: 4.3e-58
                 TTEEEEEXXTTSXSSEESEEEEXTTSEEETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHHHTTXSSEEEEE.TTSBEEEEEEETTEEEEHHHHHH CS
       HSP70  18 ggkievianeegnrttPsvvaFtkkerlvGeaAkrqavtnpkntvfsvKrliGrkfsdpevqkeikelpykvvkk.engkavveveaagekftpeqisa 115
                 ++++ +i+ne g++ tPsv+     + +v  ++ ++++   ++ ++ +  l G +   ++v  + ke+  + ++k ++g+    ++++g ++t +++ +
  EFC37340.1  94 NTHVVIIQNEDGAHHTPSVIKV---NTIVEGEGDNETT--REEIIVGFPPLPGASIPADQVVYDLKEFILESEEKiKKGEEEELISFNGAEYTQDHMVS 187
                 56789**************965...5677666666655..5689************99999999999988776652344455556778*********** PP

                 HHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSS......SCEEEEEEEEXSSXEEEEEEEEE.T CS
       HSP70 116 mvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkd......kernvlvyDlGggtfdvSilele.k 207
                  +L k+k++ae+ylgk+v+++v+++P+    ++ + +k A +  G+nvl ++ ep Aa + YG+d         ke++v v+D+G   +++S+++++ +
  EFC37340.1 188 ILLGKMKNIAEHYLGKTVKKVVVSCPSNSPHSE-KVIKKACETLGMNVLAVLKEPLAALIGYGFDLPPatveekKEKIVCVVDVGALETNISVVRVNeN 285
                 ***************************877776.689***************************97656667779*********************868 PP

                 TEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHH......SX...XGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTEEEEEEEEHHH CS
       HSP70 208 GvfevkaTagDthlGGedfDealvehlveefkkke......gi...dlskdkkalqrlkeaaekaKkeLSsskqteinleietvdedgkdlseklsRak 297
                 G++++        lGGe  D++l++ +++efk+ +      ++   ++ k++k+l++l+  +e+aK  LS   ++++ ++++++ + g d+s kl+Ra+
  EFC37340.1 286 GMLQMIKSESKRPLGGESLDQVLIQMCLQEFKRLYfrsmneRMfqdEVGKNRKVLSKLRFSCENAKNVLSM--NQQAMVDVDSLYD-GMDFSFKLTRAR 381
                 ********************************854222222223436789*********************..7889999*****9.************ PP

                 HHHHHHHHHHHTHHHHHH...HHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTTCHHBSSSHTTTHHHHHHHHHHHHHC CS
       HSP70 298 feelvedllertlepvek...alkdaklkkeeidevvlvGGstRiPkvqelvkelfgkepsktvnpDeavaiGAAvqagvls 376
                 +e+ ++ +++ ++e  ++    l+d +++ + i++vvlvGGs  iPk++++++ lf +    +    + +aiG+A+qa++ +
  EFC37340.1 382 YESSAMSIFASIIEHAKQtveSLADQGISLSSIEHVVLVGGSCQIPKLKDSIQTLFSQAKIYDNAVEDSIAIGCAIQANLIN 463
                 ***999999998887765222699*********************************999888888999*********9865 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.4   0.6   5.1e-16   2.3e-12      77     323 ..     185     463 ..     178     467 .. 0.73

  Alignments for each domain:
  == domain 1  score: 46.4 bits;  conditional E-value: 5.1e-16
                 HHHHHHHHHHT..SS-S..S--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--.....TTSSS-EE..EEEE-SS-EEEEEEET CS
    MreB_Mbl  77 llkyfikkvkk..kksl..skprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglp.....veepsgnm..vvdiGggttevavisl 164
                 ++  ++ k+k+  ++ l  + ++vv+++Ps++ + e + +k+a++++G +   +++eplaA iG g +     vee + ++  vvd+G+  t+++v+ +
  EFC37340.1 185 MVSILLGKMKNiaEHYLgkTVKKVVVSCPSNSPHSE-KVIKKACETLGMNVLAVLKEPLAALIGYGFDlppatVEEKKEKIvcVVDVGALETNISVVRV 282
                 55555555555432233225689********98876.58*************************998633444677777652369***********987 PP

                 TE.....EEEEEEES.-SHHHHHHHHHHHHHHHHSEE.--HHHHHHHHHHH-BSS--HHHH...............EEEEEEEETTTTCEEEEEEEHHH CS
    MreB_Mbl 165 gg.....ivtsksvr.vaGdeldeaiikyirkkynll.iGertaekikieigsavkeeeee...............kmeikGrdlvtglpkevevssee 241
                 ++     +++s+s r ++G++ld+ +i+   ++++ l   + + +  + e+g++ k  ++                +  +    l  g+  +++++ ++
  EFC37340.1 283 NEngmlqMIKSESKRpLGGESLDQVLIQMCLQEFKRLyFRSMNERMFQDEVGKNRKVLSKLrfscenaknvlsmnqQAMVDVDSLYDGMDFSFKLTRAR 381
                 64222226777776559**********998888875414444444556677765442221111111111233233356677788999************ PP

                 HHHHHHHHHHHHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS-EEE-SSTTTHHHHHHHHTTC-HH CS
    MreB_Mbl 242 vrealkepvsaiveavkevLektppeLaadivdrgivltGGgallkgldkllseetglpvkvaedpltcvakGtgkvleklk 323
                  +++  + +++i+e +k++ e+ + + ++    + +vl+GG+ ++  l++ ++  ++   ++ +   +++a G+++ ++ ++
  EFC37340.1 382 YESSAMSIFASIIEHAKQTVESLADQGISLSSIEHVVLVGGSCQIPKLKDSIQTLFSQAKIYDNAVEDSIAIGCAIQANLIN 463
                 ***********************9998888888899****************999987776677777899999988776655 PP

>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.1   2.3e-06      0.01     102     243 ..     212     364 ..     176     368 .. 0.74
   2 !    8.0   0.0   0.00022      0.97     298     350 ..     386     439 ..     369     462 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 2.3e-06
       Actin 102 pplnppkqrekalEivfEkfkvpalylaksavlsafasgks............tglvvDsGasvt..svvpVldGyvLk..kairrsdlgGkaLteqlk 184
                 +p n+p+  ek++  + E+++++ l + k++  ++  +g                +vvD+Ga +t  svv V ++ +L+  k+  + +lgG+ L++ l 
  EFC37340.1 212 CPSNSPH-SEKVIKKACETLGMNVLAVLKEPLAALIGYGFDlppatveekkekIVCVVDVGALETniSVVRVNENGMLQmiKSESKRPLGGESLDQVLI 309
                 3444443.37788888999999999999999999999998899999999999999******865522788999999998446777889*********** PP

       Actin 185 ellssknvevtprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcev 243
                 ++  ++      r  +++ + +  ++++ k+++   +  ++  + ++vl++ ++++++v
  EFC37340.1 310 QMCLQE----FKRLYFRSMNERMFQDEVGKNRKVLSKLRFSCENAKNVLSMNQQAMVDV 364
                 999986....4455555555555555555666666666777777777777777777766 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00022
       Actin 298 ekskllgiselivaaina.cdvdlrpeLlanivvtGGnsllpglteRlekelaq 350
                  +s + +i e ++++++  +d  +  + ++++v++GG+  +p+l++ +++  +q
  EFC37340.1 386 AMSIFASIIEHAKQTVESlADQGISLSSIEHVVLVGGSCQIPKLKDSIQTLFSQ 439
                 366678888899999987358999*********************999876665 PP

>> PilM_2  Type IV pilus assembly protein PilM;
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0   0.00019      0.87     175     200 ..     258     283 ..     251     310 .. 0.86
   2 !    5.0   0.0    0.0024        11     273     296 ..     412     435 ..     380     462 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00019
      PilM_2 175 dkgkekvvaivdigasrttlsvlrdg 200
                 +++kek+v++vd+ga +t++sv+r +
  EFC37340.1 258 EEKKEKIVCVVDVGALETNISVVRVN 283
                 578999****************9865 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0024
      PilM_2 273 nkvdkilLaGGtaslpgleellee 296
                 +++++++L GG+ ++p l++ +++
  EFC37340.1 412 SSIEHVVLVGGSCQIPKLKDSIQT 435
                 689*****************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (473 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1386  (0.0773049); expected 358.6 (0.02)
Passed bias filter:                      703  (0.0392102); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.37s 00:00:01.12 Elapsed: 00:00:00.52
# Mc/sec: 2757.57
//
Query:       EFC37341.1  [L=354]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       416  (0.0232026); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2432.33
//
Query:       EFC37342.1  [L=850]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   7.8e-104  339.3  18.3    5.7e-16   58.0   0.1   10.2 10  DUF4116         Domain of unknown function (DUF4116)
    2.4e-26   92.7   0.0    6.1e-26   91.4   0.0    1.7  1  Pkinase         Protein kinase domain
    1.3e-07   31.1   0.0    4.7e-07   29.4   0.0    1.8  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0069   15.2   0.0      0.014   14.2   0.0    1.5  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.011   15.8   0.0        5.8    7.1   0.0    2.8  2  DUF4853         Domain of unknown function (DUF4853)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.9   0.0   8.2e-15     3e-11       1      46 [.     417     462 ..     417     466 .. 0.97
   2 !   30.0   0.1   8.5e-11   3.1e-07       1      44 [.     467     510 ..     467     510 .. 0.99
   3 !   52.5   0.0   8.2e-18   2.9e-14       1      48 [.     492     539 ..     492     540 .. 0.99
   4 !   41.9   0.0   1.7e-14   6.2e-11       1      49 []     541     591 ..     541     591 .. 0.94
   5 !   26.6   0.2     1e-09   3.7e-06       1      29 [.     593     621 ..     593     625 .. 0.96
   6 !   52.7   0.0   6.9e-18   2.5e-14       1      49 []     661     709 ..     661     709 .. 0.98
   7 !   50.9   0.2   2.6e-17   9.5e-14       1      48 [.     711     758 ..     711     759 .. 0.97
   8 !   34.0   0.3   4.9e-12   1.8e-08       1      49 []     761     812 ..     761     812 .. 0.85
   9 !   58.0   0.1   1.6e-19   5.7e-16       1      49 []     789     837 ..     789     837 .. 0.99
  10 !   29.5   0.0   1.2e-10   4.4e-07       1      33 [.     814     846 ..     814     846 .. 0.95

  Alignments for each domain:
  == domain 1  score: 42.9 bits;  conditional E-value: 8.2e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 DrEivl avk n + + +++e+Lk+D+e++l+Av q  +++ y+++
  EFC37342.1 417 DREIVLRAVKLNEKGILHVDESLKSDREFILQAVSQKTSSFQYLDD 462
                 9******************************************987 PP

  == domain 2  score: 30.0 bits;  conditional E-value: 8.5e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 DrEi l av+ +g  +k l+e+Lk+D+eivl+A +++ +a++y+
  EFC37342.1 467 DREISLIAVREHGAFFKLLDESLKKDREIVLAATNRDTNAFEYI 510
                 9*****************************************97 PP

  == domain 3  score: 52.5 bits;  conditional E-value: 8.2e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrEivl a  ++ +a++y+++++k+D+e++  A+k++g+al ++s+eL
  EFC37342.1 492 DREIVLAATNRDTNAFEYIDDSFKSDREFMVNAIKKHGIALGFVSKEL 539
                 9**********************************************9 PP

  == domain 4  score: 41.9 bits;  conditional E-value: 1.7e-14
     DUF4116   1 DrEivleavkkngsalkylseeLkn..DkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vl av++ng+al  +++ +k   D+eiv+kAv+q+g+al+ya + Lr
  EFC37342.1 541 DRELVLLAVQQNGYALGSVDSAFKFneDREIVMKAVQQSGDALRYAAPLLR 591
                 9*******************9988877*******************88887 PP

  == domain 5  score: 26.6 bits;  conditional E-value: 1e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkei 29 
                 DrEiv+ a+ ++g+a+++++e+L+nD ei
  EFC37342.1 593 DREIVKIAICQDGKAIYHVDESLRNDEEI 621
                 9***************************9 PP

  == domain 6  score: 52.7 bits;  conditional E-value: 6.9e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr ivl av++ng++l++ ++ +k+D+eiv+kAv++ng al++a+e L+
  EFC37342.1 661 DRHIVLLAVEQNGLSLEFSDDIFKRDREIVMKAVQKNGLALEFADETLK 709
                 899*******************************************996 PP

  == domain 7  score: 50.9 bits;  conditional E-value: 2.6e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrEivl a+  n +a++y++e+Lk+D++++l+Av+ +g ++ ++++++
  EFC37342.1 711 DREIVLTAINENEKAFEYADESLKCDRDFILQAVELCGWVFHFLDKSF 758
                 9******************************************99875 PP

  == domain 8  score: 34.0 bits;  conditional E-value: 4.9e-12
     DUF4116   1 DrEivleavkkngsalky...lseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+iv++a+ +   +  +   l+e++knD++iv+ Av  ng++l+y+ e+++
  EFC37342.1 761 DRDIVKKALLNKDIVWMFelaLPESMKNDRDIVMFAVSVNGFVLEYVNESFK 812
                 9*******88775544443477*************************99875 PP

  == domain 9  score: 58.0 bits;  conditional E-value: 1.6e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+iv+ av+ ng++l+y++e++k+D+eivl Avk ng+al++a+e+L+
  EFC37342.1 789 DRDIVMFAVSVNGFVLEYVNESFKKDREIVLLAVKENGNALEFADESLQ 837
                 9*********************************************996 PP

  == domain 10  score: 29.5 bits;  conditional E-value: 1.2e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkA 33 
                 DrEivl avk ng+al++++e+L+ D eiv ++
  EFC37342.1 814 DREIVLLAVKENGNALEFADESLQTDLEIVSAC 846
                 9****************************9765 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.4   0.0   1.7e-29   6.1e-26      14     260 ..      57     337 ..      54     340 .. 0.84

  Alignments for each domain:
  == domain 1  score: 91.4 bits;  conditional E-value: 1.7e-29
                 EEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE...............SSEEEEEEE--TTEBHHHHHHHHSS-- CS
     Pkinase  14 kVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee...............kdelylvleyveggeladllerkgsls 96 
                 +V+k+v  +++++++vK ikke+++  ++ + ++E   + +++ h+  ++l e++ +               +d++++++   +g +la++ + +++l 
  EFC37342.1  57 RVFKCVGIQDDEEYVVKFIKKERKRCYED-DGIEEGDDFDSYDyHMGEIELGETIGNlldssvltfecsvplDDQVFILVSKYRGITLAEYRHSERKLM 154
                 79********************9998776.778888888888888888888888888888888888888888777777777777788******99**** PP

                 HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE.........EEE-SGTTSEESSSSCS.......BCTTTSCGGGS-HHHHTTSCBSHHHH CS
     Pkinase  97 eeeakkiakqilegleylHskgiiHrDlKpeNiLidekge.........lKitDFGlakelesssk.......ltsfvgtseYlAPEvlkeneyskkvD 179
                  +e+ +i+ +++++l+ +H+k+iiH D+Kp+Ni+i e ++         + ++DFG a+  +++++        + + gt  Y +PE         + D
  EFC37342.1 155 LCEVLQILIRLVNALKLIHDKQIIHHDIKPANIFITEIAVsdyslpalsVVLGDFGAASIHKTNEEldedeefNECQRGTTGYFPPEN----YSCLEGD 249
                 ************************************8444556677777**********9999999999999888899********94....457899* PP

                 HHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.....SHH...HHHTTS.........-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 180 vWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasei.........seeakdllkkllkkdpkkRltaeellq 260
                 +WslG  ++ ll+ k+ +++++ ++++  e++++ + + i +     +         e+          +++  +lk++l+ dp++R++++++l 
  EFC37342.1 250 IWSLGRSFLLLLFPKNSLNSSEMESDYLDEITDTIQEMSIYEnstirK-------LIEMgdleedlngWKKFFLILKEMLNIDPNQRPSCSQILT 337
                 *******************88888888888888555555554332221.......22225556667778999999*****************997 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4   0.0   1.3e-10   4.7e-07      73     257 ..     128     337 ..     108     339 .. 0.78

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 1.3e-10
                  SSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.........TTEEEE-STTTHEETTTSSEEEE CS
  Pkinase_Tyr  73 eepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.........nkvvkisDfGLardiekddeyvk 161
                  +++++i++   +g +L ++ +++  +kl l ++l++ + + ++++ +++k+++H d+   N++++e            v ++DfG a+ +++++e  +
   EFC37342.1 128 DDQVFILVSKYRGITLAEYRHSE--RKLMLCEVLQILIRLVNALKLIHDKQIIHHDIKPANIFITEiavsdyslpALSVVLGDFGAASIHKTNEELDE 223
                  45555666666667788886665..99**********************************************9999*********999977777755 PP

                  TTS....STSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGT.................TTTS..HHHHHHHHHHTTEES-BBTTSBHHHHH CS
  Pkinase_Tyr 162 kee....aklpvkWmapEslkekkftsksDvWsfGvllwEiftlgesp.................ypgl..kneevleklkegkrlekpekcpeelye 236
                  +ee    ++    + +pE  +      + D+Ws G     ++   +++                 ++++   ++++++kl e   le+  + ++++  
   EFC37342.1 224 DEEfnecQRGTTGYFPPENYS----CLEGDIWSLGRSFLLLLF-PKNSlnssemesdyldeitdtIQEMsiYENSTIRKLIEMGDLEEDLNGWKKFFL 316
                  554111144556677777554....568999*99965443332.33333456699999999999955553356678899999999************* PP

                  HHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 237 lmkkcweedpeeRptfselve 257
                  ++k+ ++ dp++Rp+ s++++
   EFC37342.1 317 ILKEMLNIDPNQRPSCSQILT 337
                  ****************99976 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.0   3.9e-06     0.014     305     366 ..     155     219 ..      56     239 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 3.9e-06
  Pkinase_fungal 305 pkellealrDaIkghrsLflkagiLHrDiSenNilitdskke....gerkglLiDLDlakelsdds 366
                      +e+l+ l+  +++++  + +++i+H Di   Ni it+ +      +  + +L D+  a+ +++++
      EFC37342.1 155 LCEVLQILIRLVNALKLIH-DKQIIHHDIKPANIFITEIAVSdyslPALSVVLGDFGAASIHKTNE 219
                     4688999999999999888.*****************76433355677777777777777666533 PP

>> DUF4853  Domain of unknown function (DUF4853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0    0.0016       5.8      56     103 ..     675     722 ..     662     730 .. 0.88
   2 ?    5.5   0.0     0.005        18      68     126 ..     790     846 ..     782     849 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0016
                 EEEEE---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET. CS
     DUF4853  56 tlyipeidfddlrevveeelkplGfkysekpderdkdesrtvvwgder 103
                 +l+++   f++ re+v ++++++G++++  +++ +kd + ++ + +e+
  EFC37342.1 675 SLEFSDDIFKRDREIVMKAVQKNGLALEFADETLKKDREIVLTAINEN 722
                 677888889999****************************99888873 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.005
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEEEE-SS.EEEEEEE--- CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyGgslsvkyseddrisvhyesgc 126
                 r++v  +++ +Gf+++  ++ ++kd + ++++  e +G+ l++   e+ ++  +  s+c
  EFC37342.1 790 RDIVMFAVSVNGFVLEYVNESFKKDREIVLLAVKE-NGNALEFA-DESLQTDLEIVSAC 846
                 789999999*******************9988888.9*****95.45556666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (850 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.82u 0.33s 00:00:01.14 Elapsed: 00:00:00.52
# Mc/sec: 4899.71
//
Query:       EFC37343.1  [L=520]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.074   13.2   2.2         25    5.3   0.1    4.4  4  TPR_2     Tetratricopeptide repeat
       0.11   12.2   0.3         16    5.1   0.1    2.8  3  DUF5537   Family of unknown function (DUF5537)
        1.2    9.0   3.9         29    4.7   0.1    4.2  4  TPR_1     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0         3   1.8e+04      15      20 ..     159     164 ..     157     165 .. 0.76
   2 ?    3.0   0.0     0.023   1.4e+02      15      33 ..     187     205 ..     185     206 .. 0.91
   3 ?    0.8   0.0      0.12   7.1e+02      16      30 ..     378     392 ..     363     395 .. 0.87
   4 ?    5.3   0.1    0.0042        25      12      29 ..     435     452 ..     432     455 .. 0.86

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3
       TPR_2  15 gdyeeA 20 
                 +dy++A
  EFC37343.1 159 QDYDKA 164
                 688888 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.023
       TPR_2  15 gdyeeAleafekAleldPn 33 
                 +d+ +Al++  +++e +Pn
  EFC37343.1 187 QDLRQALHYVTRSIESNPN 205
                 6899**************9 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.12
       TPR_2  16 dyeeAleafekAlel 30 
                 ++e A+e+ e+A +l
  EFC37343.1 378 NPEHAKEDIERATQL 392
                 57999******9988 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.0042
       TPR_2  12 yklgdyeeAleafekAle 29 
                  ++ ++e Ale++++A++
  EFC37343.1 435 CQQTNPELALEYLNEAIK 452
                 68899***********98 PP

>> DUF5537  Family of unknown function (DUF5537)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0    0.0056        34      48     125 ..     176     251 ..     159     259 .. 0.84
   2 ?   -2.4   0.0      0.54   3.2e+03     135     148 ..     467     480 ..     462     494 .. 0.82
   3 ?    5.1   0.1    0.0027        16       7      34 ..     491     518 ..     482     520 .] 0.83

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0056
     DUF5537  48 fgleelkeclkmpylpelqscskslsssplevpkrllraeaevsavrlkktkescsvaalqekskgsvfsdpltgaps 125
                 fg+    +++k      l+ +++s+ s p    k l rae +         ke+     + e+s+ ++ s+   gap 
  EFC37343.1 176 FGFASFCKVVKQDLRQALHYVTRSIESNPNAPIKFLKRAELQFELF--EYLKETGENMRVEERSNSTGASNNNGGAPE 251
                 777777788888888999999********99999999988777654..56677777788899***9999*99999996 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.54
     DUF5537 135 aileydtvrqettk 148
                 a l+y+t r++t+ 
  EFC37343.1 467 AFLNYETFRKQTQA 480
                 8899*****99976 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0027
     DUF5537   7 eikfetskvtrssldscllfesswkkav 34 
                 ei    ++  +s++++cllf   w+ka 
  EFC37343.1 491 EIMDRVAEDCQSAINKCLLFAKCWNKAC 518
                 66666677789***************95 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       1.6   9.3e+03      22      27 ..     159     164 ..     158     165 .. 0.54
   2 ?    2.1   0.0     0.033     2e+02      15      33 ..     187     205 ..     185     206 .. 0.91
   3 ?   -0.5   0.0      0.22   1.3e+03      16      30 ..     378     392 ..     378     395 .. 0.85
   4 ?    4.7   0.1    0.0048        29      16      29 ..     439     452 ..     433     455 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.6
                 HHHHHH CS
       TPR_1  22 eyyekA 27 
                 ++y+kA
  EFC37343.1 159 QDYDKA 164
                 455555 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.033
                 T-HHHHHHHHHHHHHHSTT CS
       TPR_1  15 gkydeAleyyekALelnPn 33 
                 +++ +Al y  + +e nPn
  EFC37343.1 187 QDLRQALHYVTRSIESNPN 205
                 6889**************8 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.22
                 -HHHHHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekALel 30 
                 +++ A e+ e+A +l
  EFC37343.1 378 NPEHAKEDIERATQL 392
                 6789********887 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.0048
                 -HHHHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekALe 29 
                 +++ Aley ++A++
  EFC37343.1 439 NPELALEYLNEAIK 452
                 7899*********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (520 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1252  (0.069831); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.50
# Mc/sec: 3139.32
//
Query:       EFC37344.1  [L=280]
Description: S-adenosylmethionine-dependent methyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-20   73.7   0.1    2.2e-20   73.2   0.1    1.2  1  Methyltransf_23  Methyltransferase domain
    1.1e-15   58.1   0.0    2.2e-15   57.2   0.0    1.5  1  Methyltransf_12  Methyltransferase domain
    1.1e-13   51.7   0.0    2.7e-13   50.4   0.0    1.7  1  Methyltransf_25  Methyltransferase domain
    5.6e-12   45.7   0.0    1.1e-11   44.8   0.0    1.6  1  Methyltransf_31  Methyltransferase domain
    5.6e-11   43.0   0.0    1.1e-10   42.0   0.0    1.5  1  Methyltransf_11  Methyltransferase domain
    1.1e-08   34.8   0.0    1.6e-08   34.2   0.0    1.4  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
    1.5e-06   27.9   0.1    3.7e-06   26.6   0.1    1.8  1  MTS              Methyltransferase small domain
    1.4e-05   24.6   0.3    4.1e-05   23.1   0.1    1.9  2  TehB             Tellurite resistance protein TehB
    0.00035   20.2   0.0    0.00057   19.5   0.0    1.2  1  Methyltransf_PK  AdoMet dependent proline di-methyltransferas
    0.00055   19.2   0.2       0.37   10.0   0.0    2.3  2  Methyltransf_7   SAM dependent carboxyl methyltransferase
     0.0011   18.9   0.4     0.0018   18.3   0.0    1.5  2  Methyltransf_32  Methyltransferase domain
     0.0046   15.9   0.0     0.0058   15.6   0.0    1.4  1  Methyltransf_9   Protein of unknown function (DUF1698)
  ------ inclusion threshold ------
      0.013   15.3   0.3      0.034   13.9   0.1    1.7  2  Methyltransf_16  Lysine methyltransferase
      0.022   14.7   0.0       0.06   13.3   0.0    1.7  2  Methyltransf_18  Methyltransferase domain
      0.041   13.1   0.0       0.36   10.0   0.0    1.9  2  DUF276           DUF276
      0.048   13.0   0.0       0.16   11.3   0.0    2.0  2  CMAS             Mycolic acid cyclopropane synthetase
       0.08   12.5   0.2        0.2   11.2   0.1    1.8  2  TRM13            Methyltransferase TRM13
        0.1   12.4   0.0       0.19   11.6   0.0    1.3  1  DUF2691          Protein of unknown function (DUF2691)
       0.12   11.7   0.1       0.19   11.1   0.1    1.5  1  PrmA             Ribosomal protein L11 methyltransferase (Prm
       0.15   12.4   0.0       0.26   11.6   0.0    1.6  1  AdoMet_MTase     Predicted AdoMet-dependent methyltransferase


Domain annotation for each model (and alignments):
>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.2   0.1   2.4e-23   2.2e-20      12     164 ..      82     251 ..      67     252 .. 0.75

  Alignments for each domain:
  == domain 1  score: 73.2 bits;  conditional E-value: 2.4e-23
  Methyltransf_23  12 klerllpk...lraggrvLdiGcGtGillevl.rengfsvtgvDlspeaveiae.......kakkaqkdqfdeqeaae................ 78 
                      ++     k   +++++ v+d+GcGtG l+ +l  e+g sv+  D+ ++  ++++       k                                
       EFC37344.1  82 LR-----KhltNQSSMQVMDFGCGTGALSLYLlNEYGQSVECLDAVDVSEGMLKqfaekkeK---------------Lvgegmlngnllqihnl 155
                      22.....22339999***************99899999999999998888887333333330...............13333333333333333 PP

  Methyltransf_23  79 ...........pqgkfdlIvlrevlehvpdppellrqiatllkpgGylllseplaslkedrllldwlylvpagrhisffsarslkelleeaGle 161
                                 +++++dlIv++++++h+p+ pe l+ +a++lkp G l++++ +++ +  + ++   + ++  +  s fs+ +l+e+l  aG+e
       EFC37344.1 156 nlttddhaligKKNSYDLIVSSMCFHHLPNIPEKLKLFASYLKPSGKLVFLDMDKDFPLIETFHPRNMGDEL-QYESGFSEAELREWLDLAGFE 248
                      33333444444666*******************************************9****9987777755.77899**************** PP

  Methyltransf_23 162 vve 164
                      +++
       EFC37344.1 249 NHQ 251
                      985 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.2   0.0   2.5e-18   2.2e-15       1      99 []      95     203 ..      95     203 .. 0.95

  Alignments for each domain:
  == domain 1  score: 57.2 bits;  conditional E-value: 2.5e-18
  Methyltransf_12   1 LeiGcGtGsllrallekl.pdieyt.gvDispsai...edakeklakrennnnnnvelealdlldldgg.....ssfDlvvasnvlhhlkdire 84 
                      +++GcGtG+l+ +ll++  + +e + +vD+s+ ++   + +kekl  ++ +n n +++ +l+l  +d       +s+Dl+v+s ++hhl++i e
       EFC37344.1  95 MDFGCGTGALSLYLLNEYgQSVECLdAVDVSEGMLkqfAEKKEKLVGEGMLNGNLLQIHNLNLTTDDHAligkkNSYDLIVSSMCFHHLPNIPE 188
                      69****************99999999*********99999999999999999999*******9988888************************* PP

  Methyltransf_12  85 vldnirklLkpgGrl 99 
                       l+ +++ Lkp G+l
       EFC37344.1 189 KLKLFASYLKPSGKL 203
                      *************87 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.4   0.0     3e-16   2.7e-13       1      97 []      94     201 ..      94     201 .. 0.79

  Alignments for each domain:
  == domain 1  score: 50.4 bits;  conditional E-value: 3e-16
                      EEEET-TTSHHHHHHHCTST..SSEEEEEESSHHHHHHHHHHHHH...TTT....TEEEEESBC....CGBSSSTTTEEEEEEESTGGGSSHHH CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrlg..kakvtgvDiseemleaareraee...egl....nvefvqgda....edlpfedgsfDlvvssgalhhlsded 81 
                      v+d+GcGtG l+l+l++++g   + + +vD+se+ml++ +e+ e+   eg+     +++++ ++    ++l  +++s+Dl+vss+++hhl+  +
       EFC37344.1  94 VMDFGCGTGALSLYLLNEYGqsVECLDAVDVSEGMLKQFAEKKEKlvgEGMlngnLLQIHNLNLttddHALIGKKNSYDLIVSSMCFHHLP--N 185
                      89*****************645778899**********99999888885556444333444444221133556999********9****98..8 PP

                      HHHHHHHHHHHEEEEE CS
  Methyltransf_25  82 lekalkeiarvLkpgG 97 
                      +++ lk +a+ Lkp G
       EFC37344.1 186 IPEKLKLFASYLKPSG 201
                      9999**********98 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.8   0.0   1.2e-14   1.1e-11       2     119 ..      89     213 ..      88     271 .. 0.76

  Alignments for each domain:
  == domain 1  score: 44.8 bits;  conditional E-value: 1.2e-14
  Methyltransf_31   2 dkglrvlDlGCGtGeltfelaeelgpkae.vvGiDiseeaielArenaqklgldnveFeqgdieelekl.led.........ekfDlilsnevl 84 
                      ++ ++v+D GCGtG+l++ l  e g+  e +  +D se ++++  e+ +kl  +   +  g+  ++ +l l+          +++Dli+s   +
       EFC37344.1  89 QSSMQVMDFGCGTGALSLYLLNEYGQSVEcLDAVDVSEGMLKQFAEKKEKLVGE--GMLNGNLLQIHNLnLTTddhaligkkNSYDLIVSSMCF 180
                      689***********************9998889*********999987777666..34444444433333333458889999************ PP

  Methyltransf_31  85 naladpdkileeiervlkpggilliedprllaelp 119
                      ++l++ ++ l+   ++lkp g l+  d++  +++p
       EFC37344.1 181 HHLPNIPEKLKLFASYLKPSGKLVFLDMD--KDFP 213
                      ***************************99..3333 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.0   0.0   1.2e-13   1.1e-10       2      96 .]      96     205 ..      95     205 .. 0.76

  Alignments for each domain:
  == domain 1  score: 42.0 bits;  conditional E-value: 1.2e-13
                      EET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHH...HHHCCHHT-......EEEE....TTEECCCTSS-TT-EEEEEEES-CCC-CCHH CS
  Methyltransf_11   2 dvGcGtGrlaealakrg....arvvgvDlskemlkla...kekaseegl......kvef....vvadaeklpfednsfDlvvssevlhhvedpe 78 
                      d+GcGtG+l+ +l + +    + + +vD+s+ mlk+    kek ++  +       +++    +  d + l  ++ns+Dl+vss+++hh+++  
       EFC37344.1  96 DFGCGTGALSLYLLNEYgqsvECLDAVDVSEGMLKQFaekKEKLVG--EgmlngnLLQIhnlnLTTDDHALIGKKNSYDLIVSSMCFHHLPNIP 187
                      99************5554665666689999***9666333444444..255989844442223455555688899******************* PP

                      HHHHHHHHHEEEEEEEEE CS
  Methyltransf_11  79 kalkeiaRvLkpgGllvi 96 
                      + lk +a  Lkp G+lv+
       EFC37344.1 188 EKLKLFASYLKPSGKLVF 205
                      ****************97 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.2   0.0   1.8e-11   1.6e-08      41     156 ..      84     210 ..      33     219 .. 0.79

  Alignments for each domain:
  == domain 1  score: 34.2 bits;  conditional E-value: 1.8e-11
                      HH--S--TTEEEEES-TT-HHHHHHHHHHHHHHE.EEEEES-HHHHHH...HHHHHHHHTSS.....TEEE..EE--TTT-TTS-T-EEEEEEE CS
  Ubie_methyltran  41 klvavkrgakvlDvagGtgDlafklsdsvgekgk.vvvlDinenmLkv...gekklkeegki.....nief..lqanaeeLpfeddsfDvvtvs 123
                      k  +++++ +v+D  +Gtg l++ l+++ g++ + ++ +D++e mLk+    ++kl  eg+      +i+   l+++  +L  +++s+D++  s
       EFC37344.1  84 KHLTNQSSMQVMDFGCGTGALSLYLLNEYGQSVEcLDAVDVSEGMLKQfaeKKEKLVGEGMLngnllQIHNlnLTTDDHALIGKKNSYDLIVSS 177
                      4445566679********************99953799********9631145566677887555555554113455667777889******** PP

                      S-GGG-S-HHHHHHHHHHHEEEEEEEEEEEE-- CS
  Ubie_methyltran 124 fGlrnvtDklkaLkeayrvlkpGGrlvvlefsk 156
                        +  ++++++ Lk     lkp G+lv l++ k
       EFC37344.1 178 MCFHHLPNIPEKLKLFASYLKPSGKLVFLDMDK 210
                      ****************************99876 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.6   0.1   4.1e-09   3.7e-06      23     109 ..      82     182 ..      54     209 .. 0.67

  Alignments for each domain:
  == domain 1  score: 26.6 bits;  conditional E-value: 4.1e-09
                 HHHHCHCCTCSEEEEET-TTSHHHHHHHHHTTC.E..EEEEESBHHHHHHHHHHHHHTTGC.......EEEEE-STTTT.....STTS-EEEEEE---S CS
         MTS  23 LletlpkelsgkvlDlGcGaGvlgaalakespeae..vtlvdvdarAlesakenleankle.......vevvasdvlee.....veekkfdlivsNPPf 107
                 L ++l+++ s +v+D+GcG+G+l++ l++e+ +    +++vdv+   l+   e  e+   e       +++++ +++ +      +++++dlivs   f
  EFC37344.1  82 LRKHLTNQSSMQVMDFGCGTGALSLYLLNEYGQSVecLDAVDVSEGMLKQFAEKKEKLVGEgmlngnlLQIHNLNLTTDdhaliGKKNSYDLIVSSMCF 180
                 55799999999*****************99988544788888888777655544444333333344453444333333211111345677777776666 PP

                 TT CS
         MTS 108 ha 109
                 h+
  EFC37344.1 181 HH 182
                 65 PP

>> TehB  Tellurite resistance protein TehB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       2.3   2.1e+03      78      95 ..      40      57 ..      27      88 .. 0.61
   2 !   23.1   0.1   4.6e-08   4.1e-05      29     127 ..      89     200 ..      70     242 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.3
                TTEEEEE--GGG----S- CS
        TehB 78 knistalydineaklder 95
                k++s +++d+n+ ++d+ 
  EFC37344.1 40 KKMSQQVIDLNKQHFDKM 57
                347778888888888764 PP

  == domain 2  score: 23.1 bits;  conditional E-value: 4.6e-08
                 S-S-EEEEES-TTSHHHHHH.HHTT-EEEEEES-HHHHHHHHHHHHH.TT-TT...EEEEE--GGG---..........-S-EEEEEEESSGGGS-GGG CS
        TehB  29 vkpgkvldlgcgqgrnslyl.sllgydvtawdknensiafleeikek.enlkn...istalydineakl..........derydfilstvvlmfleaer 112
                  +  +v+d+gcg g  slyl +  g  v+++d  + s ++l++ +ek e+l +   ++ +l++i +++l          ++ yd+i+s++ +  l    
  EFC37344.1  89 QSSMQVMDFGCGTGALSLYLlNEYGQSVECLDAVDVSEGMLKQFAEKkEKLVGegmLNGNLLQIHNLNLttddhaligkKNSYDLIVSSMCFHHLP--N 185
                 567899*************64789****************99988752666432335666666666655222222222235699999988776663..4 PP

                 HHHHHHHHHHTEEEE CS
        TehB 113 ipsiienmqectkvg 127
                 ip+ ++ +  + k+ 
  EFC37344.1 186 IPEKLKLFASYLKPS 200
                 565555555555555 PP

>> Methyltransf_PK  AdoMet dependent proline di-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   6.3e-07   0.00057      38     159 ..      71     205 ..      63     212 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 6.3e-07
  Methyltransf_PK  38 srkflkklkkeslp..gkrevkvaldcGaGiGrvtknlLlkll......skvDlvep.vekflekakeelae..ekkkvgkvyvvglqeftPe. 119
                      srkf + + +e     ++++   ++d G+G G ++  lL ++         vD+ e  +++f ek ++ ++e   + +  +++++ l   t + 
       EFC37344.1  71 SRKFATGIMEELRKhlTNQSSMQVMDFGCGTGALSLYLLNEYGqsveclDAVDVSEGmLKQFAEKKEKLVGEgmLNGNLLQIHNLNL---TTDd 161
                      6777666665543311455667799**************999855555466676664146777777777777332233333443333...3333 PP

  Methyltransf_PK 120 ......egrYdliWiqWcvghLtDedlvaflkrckkalkpnGlivv 159
                            +++Ydli    c  hL++  + + lk  +++lkp G +v 
       EFC37344.1 162 haligkKNSYDLIVSSMCFHHLPN--IPEKLKLFASYLKPSGKLVF 205
                      4455559***************95..66778888888888888875 PP

>> Methyltransf_7  SAM dependent carboxyl methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0   0.00041      0.37       6      35 ..      82     111 ..      77     125 .. 0.80
   2 !    7.0   0.0    0.0032       2.9     107     131 ..     168     192 ..     165     205 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00041
                     S----SS---EEEEEET--SSCHHHHHHHH CS
  Methyltransf_7   6 lllkslspeslkiaDLGCSsGpNtllvvse 35 
                     l  + ++++s+++ D+GC +G+ +l +++e
      EFC37344.1  82 LRKHLTNQSSMQVMDFGCGTGALSLYLLNE 111
                     554555789*************99998877 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0032
                     TT-EEEEEEES-TTB-SS--GGG.. CS
  Methyltransf_7 107 snslhlvhssysLhWlSqvpeelek 131
                     +ns +l++ss+++h l ++pe+l+ 
      EFC37344.1 168 KNSYDLIVSSMCFHHLPNIPEKLKL 192
                     6899******************954 PP

>> Methyltransf_32  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       7.8     7e+03      49      64 ..      39      54 ..      29      58 .. 0.52
   2 !   18.3   0.0     2e-06    0.0018      14      76 ..      79     138 ..      69     181 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 7.8
  Methyltransf_32 49 eyklkvvgidakeelv 64
                     ++k++   id+++++ 
       EFC37344.1 39 HKKMSQQVIDLNKQHF 54
                     2344455555555554 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 2e-06
  Methyltransf_32  14 akllkelakesgaltvvDvGaGkgYLsfvlalkekeyklkvvgidakeelvekaekraeklgk 76 
                       + l++  +++++++v+D+G+G g Ls  l     ey+ +v ++da +      ++ aek +k
       EFC37344.1  79 MEELRKHLTNQSSMQVMDFGCGTGALSLYLLN---EYGQSVECLDAVDVSEGMLKQFAEKKEK 138
                      3334444678899******************9...9999999988766555555555555444 PP

>> Methyltransf_9  Protein of unknown function (DUF1698)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   6.5e-06    0.0058     106     265 ..      81     252 ..       6     279 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 6.5e-06
                     HHGGGS.--TT-EEEEET-TTSHHHHHHH...HCT-SEEEEE---HHHHHHHHH.HHCCTTTTS......SEEEE---GGG...S-T---EEEEE CS
  Methyltransf_9 106 rvlphlsdlkgrtildvGcgnGyhlwrmv...gegaklvvGidPselfliqfea.vrkllgedq......rahllplgieq...lpeleafdtvf 187
                      +++hl++    +++d Gcg+G     ++   g+  +    +d se  l qf    +kl+ge        + h+l l+ ++   + + +++d + 
      EFC37344.1  81 ELRKHLTNQSSMQVMDFGCGTGALSLYLLneyGQSVECLDAVDVSEGMLKQFAEkKEKLVGEGMlngnllQIHNLNLTTDDhalIGKKNSYDLIV 175
                     6789******************7655555111556666667899999*****6515677766541111115566777766522233468999988 PP

                     EES-GGG-S-HHHHHHHHHCTEEEEEEEEEEEE-BSS-TT-EE--SS-BTTBSS---EEBHHHHHHHHHHTT-EEEEE CS
  Methyltransf_9 188 smGvlyhrrsPldhllqlkdqlvkgGelvletlvieGdenavlvPedryakmrnvyfiPsaaalkvWlekvgfvdvri 265
                     s   ++h     ++l  +   l+  G+lv+  +  +    + + P++   +++    + s a l+ Wl+ +gf + + 
      EFC37344.1 176 SSMCFHHLPNIPEKLKLFASYLKPSGKLVFLDMDKDFPLIETFHPRNMGDELQYESGF-SEAELREWLDLAGFENHQF 252
                     8777777777778898899999999999975554444444555555555555543333.4556777777777777654 PP

>> Methyltransf_16  Lysine methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       1.7   1.6e+03      86     110 ..      44      64 ..      35      79 .. 0.72
   2 ?   13.9   0.1   3.8e-05     0.034      39     152 ..      81     202 ..      66     211 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.7
  Methyltransf_16  86 kknielnknalkskvkvevLdWgee 110
                      ++ i+lnk    ++   ++LdWg++
       EFC37344.1  44 QQVIDLNK----QHFDKMALDWGTN 64 
                      45566655....7777889999976 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 3.8e-05
  Methyltransf_16  39 e..lganelsklsvlELGsGtGlvGlavaellpeakviltDleellellkknielnkn.......alkskvkvevLdWgeeleedllekeevDl 123
                      e  ++ +++s ++v++ G GtG   l + +   + +v   D  ++ e + k  +  k+       ++ +  +++ L+  ++ +  + +k+++Dl
       EFC37344.1  81 ElrKHLTNQSSMQVMDFGCGTGALSLYLLNE-YGQSVECLDAVDVSEGMLKQFAEKKEklvgegmLNGNLLQIHNLNLTTDDHALIGKKNSYDL 173
                      24456789999***************99988.46677777887777766666665555566667566677899999999998888889999*** PP

  Methyltransf_16 124 ilaaDcvYledslelLvkvLkellkkesk 152
                      i+ + c      ++  +k+    lk+++k
       EFC37344.1 174 IVSSMCFHHLPNIPEKLKLFASYLKPSGK 202
                      ******99999999888888877777766 PP

>> Methyltransf_18  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   6.7e-05      0.06      14      59 ..      89     137 ..      79     147 .. 0.81
   2 ?   -3.5   0.0       9.7   8.7e+03     121     134 ..     235     248 ..     233     251 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 6.7e-05
  Methyltransf_18  14 kgs.rvaDiGtDHgylpiylvke..gkakkviasDinegplekakenie 59 
                      ++s +v+D G+  g l++yl++e  + ++   a+D++eg l++  e+ e
       EFC37344.1  89 QSSmQVMDFGCGTGALSLYLLNEygQSVECLDAVDVSEGMLKQFAEKKE 137
                      44459****************87445788899*********99887765 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 9.7
  Methyltransf_18 121 aeelRkylvengfk 134
                      ++elR++l   gf+
       EFC37344.1 235 EAELREWLDLAGFE 248
                      5799***9988886 PP

>> DUF276  DUF276
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0    0.0004      0.36      43     119 ..      32     109 ..      16     136 .. 0.85
   2 ?    1.0   0.0      0.22     2e+02      42      73 ..     170     202 ..     152     212 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.0004
      DUF276  43 ydiiasslaliekeiievlkelfskikengsyfaalkedlssksst..yeavrkallnlegvkyiniksaagkinlyli 119
                  +i++ s   + +++i+  k+ f k+  +    + +  ++s k +t   e +rk l n   ++ ++   ++g + lyl+
  EFC37344.1  32 AEILNKSHKKMSQQVIDLNKQHFDKMALDWG-TNPIFAEMSRKFATgiMEELRKHLTNQSSMQVMDFGCGTGALSLYLL 109
                 5899**********************87643.367777788876654489***************************97 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.22
      DUF276  42 iydiiasslalie.keiievlkelfskikengs 73 
                  yd+i ss++  +  +i e+lk++ s +k++g 
  EFC37344.1 170 SYDLIVSSMCFHHlPNIPEKLKLFASYLKPSGK 202
                 589998888776536899************996 PP

>> CMAS  Mycolic acid cyclopropane synthetase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00018      0.16      56      91 ..      84     119 ..      76     205 .. 0.77
   2 ?   -1.9   0.0       1.8   1.6e+03     105     127 ..     247     269 ..     242     274 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00018
                 TTTT--TT-EEEEES-TTSHHHHHHHHHH--EEEEE CS
        CMAS  56 eklelkpGmtlLdiGcGWGslvrraverydvkvvgl 91 
                 + l+ +  m+++d GcG G+l  +  ++y+ +v  l
  EFC37344.1  84 KHLTNQSSMQVMDFGCGTGALSLYLLNEYGQSVECL 119
                 56777899**********************988654 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.8
                 HHTS-SSS-EEEEES-GGG---- CS
        CMAS 105 vdeldlerkvevklldyedldek 127
                 +++ +++r+v+++ +++ d+   
  EFC37344.1 247 FENHQFARNVTIEKKGWDDVMRS 269
                 578889999********998765 PP

>> TRM13  Methyltransferase TRM13
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   0.00022       0.2       6      43 ..      78     115 ..      74     176 .. 0.80
   2 ?   -2.4   0.0         3   2.7e+03     127     145 ..     168     186 ..     150     198 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00022
       TRM13   6 lignleelkllekssayvEfGaGkgelsryvnqaleed 43 
                 +++ l++    ++s ++++fG+G g ls y+ + + ++
  EFC37344.1  78 IMEELRKHLTNQSSMQVMDFGCGTGALSLYLLNEYGQS 115
                 5555666556688999*************998776544 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3
       TRM13 127 kakleglliAlCChhvCsw 145
                 k++ + ++  +C hh+ ++
  EFC37344.1 168 KNSYDLIVSSMCFHHLPNI 186
                 5666777888999997665 PP

>> DUF2691  Protein of unknown function (DUF2691)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00021      0.19       4     113 ..     104     213 ..     102     227 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00021
     DUF2691   4 lsfeipneygrfLlkiLkpldiasyewri.adeEsyliedgeLdealFpeeeevlegeelkktlkkkdyYliFadlkafpkkklakdiktyeeflkskc 101
                 ls+ ++neyg+  ++ L ++d+++  ++  a++   l+ +g L+ +l + ++  l+  +     kk++y li + +  ++  +++++ k + ++lk + 
  EFC37344.1 104 LSLYLLNEYGQS-VECLDAVDVSEGMLKQfAEKKEKLVGEGMLNGNLLQIHNLNLTTDDHALIGKKNSYDLIVSSMCFHHLPNIPEKLKLFASYLKPSG 201
                 567789****98.589******99877651555678**********99888877777776666699********************************* PP

     DUF2691 102 elvllivDssyv 113
                 +lv l  D  + 
  EFC37344.1 202 KLVFLDMDKDFP 213
                 *****9998875 PP

>> PrmA  Ribosomal protein L11 methyltransferase (PrmA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   0.00021      0.19     159     187 ..      88     116 ..      75     205 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00021
        PrmA 159 vkegeevlDvGtGSGiLaiaaakLgakkv 187
                 +++  +v+D+G+G+G L++  +    ++v
  EFC37344.1  88 NQSSMQVMDFGCGTGALSLYLLNEYGQSV 116
                 455569************87665544554 PP

>> AdoMet_MTase  Predicted AdoMet-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00029      0.26      42      83 ..      74     116 ..      27     155 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00029
  AdoMet_MTase  42 iaaylivlwkktrseeketsfvdvgcgngll.vyvlaaegykg 83 
                    a+ +++  +k+ ++++ +  +d gcg g l +y+l+  g   
    EFC37344.1  74 FATGIMEELRKHLTNQSSMQVMDFGCGTGALsLYLLNEYGQSV 116
                   5666777789999999************977378888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       574  (0.0320152); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1667.81
//
Query:       EFC37345.1  [L=331]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.1e-58  191.6  17.9    2.2e-08   34.5   0.1    8.1  8  Sel1           Sel1 repeat
  ------ inclusion threshold ------
       0.09   13.2   0.0       0.24   11.9   0.0    1.8  1  B12-binding_2  B12 binding domain


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   0.0   1.4e-05      0.12      14      38 .]      26      53 ..      22      53 .. 0.85
   2 !   28.7   1.5   1.6e-10   1.4e-06       2      38 .]      55      90 ..      54      90 .. 0.91
   3 !   26.2   0.0     1e-09   9.3e-06       2      38 .]      92     126 ..      91     126 .. 0.94
   4 !   23.8   0.0   5.6e-09     5e-05       1      38 []     127     162 ..     127     162 .. 0.96
   5 !   31.9   0.0   1.6e-11   1.4e-07       3      38 .]     165     198 ..     163     198 .. 0.95
   6 !   34.5   0.1   2.5e-12   2.2e-08       3      37 ..     201     233 ..     199     234 .. 0.90
   7 !   21.8   0.0   2.4e-08   0.00021       3      37 ..     237     269 ..     235     270 .. 0.91
   8 !   17.0   0.0   7.7e-07    0.0069       1      32 [.     271     300 ..     271     303 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.4e-05
        Sel1 14 lnGl..g.vpkDpekAiewyekAAeqGd 38
                 +Gl  + ++kD+ kA+ ++ +AA++G+
  EFC37345.1 26 NAGLilMeEDKDYGKALNFFLQAANMGN 53
                56777766999***************97 PP

  == domain 2  score: 28.7 bits;  conditional E-value: 1.6e-10
        Sel1  2 eAmyrLGmfylylnGlg.vpkDpekAiewyekAAeqGd 38
                 A y +G   +y++Glg + k + +A+ wy++AA++G+
  EFC37345.1 55 NAEYYVG--HMYHKGLGmEQKEIPLAFMWYQRAAQKGH 90
                699****..*******956669***************8 PP

  == domain 3  score: 26.2 bits;  conditional E-value: 1e-09
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  A+y +G fy  ++G gv+k  ek +e+  kAAe G+
  EFC37345.1  92 QALYLVGIFY--YFGFGVEKSFEKSFEYCNKAAESGH 126
                 69*****777..************************8 PP

  == domain 4  score: 23.8 bits;  conditional E-value: 5.6e-09
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 + A++++G  + yl+G gv++++e A+ w+ k+A+q++
  EFC37345.1 127 SQAQFDVG--LNYLEGEGVERNVECAMTWFTKSANQNN 162
                 68******..**************************86 PP

  == domain 5  score: 31.9 bits;  conditional E-value: 1.6e-11
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 Am +L+  +ly+ G+ +p+++++A++w  kAAe+Gd
  EFC37345.1 165 AMKKLA--QLYDIGDVIPRNVNEAFKWCLKAAELGD 198
                 999***..999***99*******************7 PP

  == domain 6  score: 34.5 bits;  conditional E-value: 2.5e-12
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 ++y+++   +y++G+g+++D +kA+ewy k+A q 
  EFC37345.1 201 SQYDVA--AMYEFGDGTERDLSKAFEWYSKSAHQK 233
                 8*****..666*********************986 PP

  == domain 7  score: 21.8 bits;  conditional E-value: 2.4e-08
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                   +++G  ++y+ G+ v+kD +k++e+  +AAeqG
  EFC37345.1 237 GEFQVG--LMYCLGKHVEKDLSKGLEFALRAAEQG 269
                 67999*..677***********************9 PP

  == domain 8  score: 17.0 bits;  conditional E-value: 7.7e-07
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyek 32 
                 + A+y ++   +y  G+g+p D+ k +ewy k
  EFC37345.1 271 SKAQYVVA--DMYARGDGTPIDVMKSYEWYSK 300
                 68******..666*****************98 PP

>> B12-binding_2  B12 binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   2.7e-05      0.24      16      69 ..     250     300 ..     207     305 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.7e-05
  B12-binding_2  16 gieelidealaqgsa.avdvlndvllpamkeVGdlfgagelflpqvllsaevmkk 69 
                     +e+++ + l    + a+++ +++l +a ++V d +++g  +  +v++s e+  k
     EFC37345.1 250 HVEKDLSKGL----EfALRAAEQGLSKAQYVVADMYARGDGTPIDVMKSYEWYSK 300
                    4555555555....67*********************************998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (331 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 1804.49
//
Query:       EFC37346.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-22   80.6   0.0    1.5e-22   80.4   0.0    1.0  1  NAD_binding_10  NAD(P)H-binding
    3.4e-08   33.2   0.0    7.4e-08   32.1   0.0    1.5  1  Epimerase       NAD dependent epimerase/dehydratase family
    1.6e-07   31.1   0.0    2.3e-07   30.6   0.0    1.2  1  NmrA            NmrA-like family
     0.0011   18.4   0.0      0.003   17.0   0.0    1.7  2  adh_short       short chain dehydrogenase
     0.0023   17.4   0.1      0.037   13.4   0.0    2.1  2  GDP_Man_Dehyd   GDP-mannose 4,6 dehydratase
  ------ inclusion threshold ------
      0.023   13.7   1.2       0.04   12.9   0.8    1.6  1  3Beta_HSD       3-beta hydroxysteroid dehydrogenase/isomerase
      0.029   14.5   0.1      0.062   13.4   0.1    1.6  1  DapB_N          Dihydrodipicolinate reductase, N-terminus
      0.029   13.6   0.1       0.04   13.2   0.1    1.2  1  ATPgrasp_ST     Sugar-transfer associated ATP-grasp


Domain annotation for each model (and alignments):
>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.4   0.0   6.7e-26   1.5e-22       1     184 []      21     221 ..      21     221 .. 0.80

  Alignments for each domain:
  == domain 1  score: 80.4 bits;  conditional E-value: 6.7e-26
                     TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHHCTTTCEEEE--TT-..CCHHHHHHTT-SEEEES---TCC....HHHH....HHHHHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRnpeklaeleaeeglevvegdvtd..vedlaealkgadaVvsalggggk....deeg....aknivdaa 85 
                     G +Gk G  l+k+l ++ g++ + lvR+++  +e++    ++v++gd+t+  ++d  + l+g+d V+ a+g++++    +  +     k +++aa
      EFC37346.1  21 GISGKLGEVLCKRLCDQ-GFKCKGLVRDEDAKKEVQGLGCTDVFVGDLTKlqTDDFVKYLEGCDFVIDAAGSTSGkdieK--IeftsGKFLAQAA 112
                     558**************.5****************9888899******95448*****************8877655430..2666689999*** PP

                     HHCT--EEEEEEETTTTSGCGCHHHHHHH....HCCHHHHHHHHHHHHHHHH..SSSEEEEEEE-CEE-ST--SEEEEET.TSS----...EEEH CS
  NAD_binding_10  86 keagvkRfvlvsaigvgdevpgefgewnk....ellkaylaakraaeellra..sgldwTivrpggLtdepttkyrvvek.gepfkgg...sisr 170
                      +++vk+++ +sa+g+++ + ge ++       +  ++y++ +++ ++ +++  ++ld+ ivr g Lt+e++ +  ++ + + + k +    +sr
      EFC37346.1 113 MKSNVKKYISMSAVGCDHFSSGERKDALVcdkcKENREYAENQYKLDQFIQNetKNLDYLIVRSGDLTEEKAMNKILIGRpHLSTKYRkmcHTSR 207
                     *****************86666655432222234669*************99777***************97766666441322222223589** PP

                     HHHHHHHHHHCTXG CS
  NAD_binding_10 171 adVAdvlvavlddp 184
                     +d+A++lv +l+++
      EFC37346.1 208 EDLANLLVCLLKND 221
                     ********999985 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.0   3.3e-11   7.4e-08       1     169 [.      17     176 ..      17     188 .. 0.80

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 3.3e-11
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC...EEEE--TT-HH..HHHHHHHHHT-SEEEE--S---HHHHHHSHHHHHHHHTHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl...elveldltdrs..alerlfkeeqpdavihlAavggvaassedpadfieknlqg 94 
                 +++tG++G +G  l+k+l ++g ++ gl r+++a+++ +   l   ++  +dlt+ +  ++ ++++  ++d vi +A+       s++ +d+ ++ +  
  EFC37346.1  17 VFITGISGKLGEVLCKRLCDQGFKCKGLVRDEDAKKEVQG--LgctDVFVGDLTKLQtdDFVKYLE--GCDFVIDAAG-------STSGKDIEKIEFTS 104
                 68*****************************777765544..255999999999876335555555..********77.......33344444577999 PP

                 HHHHHHHHHHHTCTEEEEEEE..GGGGTSCSSSSBSTCSTTS----SSHHHHHHHHHHHHHHHHHHHHT-EEEEEEE CS
   Epimerase  95 tlnlleaarkagvkrllflsS..sevYGkdaeqpkeettltgplkpnspYaaaKlageklveayaaqyglnaiilrl 169
                    l++aa k++vk+++ +s   +  +  +++   ++ +  +++k n+ Ya   +  ++ +++  ++ +l+++i+r 
  EFC37346.1 105 GKFLAQAAMKSNVKKYISMSAvgCDHFSSGER---KDALVCDKCKENREYAENQYKLDQFIQN--ETKNLDYLIVRS 176
                 999*****************954445554444...556656899******************5..677889999985 PP

>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   0.0     1e-10   2.3e-07       2     112 ..      18     135 ..      17     158 .. 0.86

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 1e-10
                 EESSTTSHHHHHHHHHHHHHT-EEEEEES-S-SHHHHHHHHSTTEEE.ES-TT..-HHHHHHHHTT-SEEEE---GG......S-HHHHHHHHHHHHHH CS
        NmrA   2 lviGaTGrqGksvvrallkaghkvralvRdtkselakslkeaGvelv.kgdld..dkeslvealkgvdvvfsvtgfy......skeiedgkklvdAake 91 
                  ++G +G++G+ + + l ++g+k + lvRd++  + k+++  G + v  gdl   + +  v+ l+g d v+ + g++      + e   gk l++Aa +
  EFC37346.1  18 FITGISGKLGEVLCKRLCDQGFKCKGLVRDED--AKKEVQGLGCTDVfVGDLTklQTDDFVKYLEGCDFVIDAAGSTsgkdieKIEFTSGKFLAQAAMK 114
                 6899*************************976..5589*******999***99556788**************999899998888999*********** PP

                 HS-SEEEEEE---GG.GT.SS CS
        NmrA  92 aGvkhfiySslgddndrsnae 112
                   vk++i  s + ++  s++e
  EFC37346.1 115 SNVKKYISMSAVGCDHFSSGE 135
                 *******77666666555555 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   1.3e-06     0.003       2     125 ..      16     133 ..      15     141 .. 0.76
   2 ?   -2.3   0.0       1.2   2.6e+03      69      86 ..     160     177 ..     150     189 .. 0.51

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.3e-06
                 EEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGGCSHHH CS
   adh_short   2 vvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkeegakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfselseee 100
                 +v++tG s+ +G  ++k+l  +G+k+  + r e+ +++ ++ l+       ++ +D+t+  +++++v+     l++ d ++  AG t  +++++++ + 
  EFC37346.1  16 CVFITGISGKLGEVLCKRLCDQGFKCKGLVRDED-AKKEVQGLGC----TDVFVGDLTKL-QTDDFVKY----LEGCDFVIDAAGSTSGKDIEKIEFTS 104
                 699***********************99888755.5455555554....78999999954.56666655....5999*********7777666655443 PP

                 ....HHHHHHHHTHHHHHHHHHHHHHHHH CS
   adh_short 101 ....wervievNltgvflltravlpamlk 125
                      ++ ++ N++ ++++++   +++ +
  EFC37346.1 105 gkflAQAAMKSNVKKYISMSAVGCDHFSS 133
                 22345777999999999999998888774 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.2
                 HHHHHHHSSESEEEE--- CS
   adh_short  69 ekavkklgkldvLvnNAG 86 
                 + +++++++ld L+   G
  EFC37346.1 160 QFIQNETKNLDYLIVRSG 177
                 445555555555554443 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.0   1.6e-05     0.037       1      33 [.      18      50 ..      18      61 .. 0.90
   2 ?    1.7   0.1     0.059   1.3e+02      29      71 ..     148     189 ..     141     192 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.6e-05
                   EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlekgyevhgivrrsss 33
                   +iTGi+G  G  l+++L+++g+++ g+vr++++
     EFC37346.1 18 FITGISGKLGEVLCKRLCDQGFKCKGLVRDEDA 50
                   69**************************98765 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.059
                    EEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHH CS
  GDP_Man_Dehyd  29 rrsssfntgriehlakdpkeeleenlklhkgDltDssslerll 71 
                    +r+++ n  ++++  +++ ++  + l + +gDlt++++++++l
     EFC37346.1 148 NREYAENQYKLDQFIQNETKN-LDYLIVRSGDLTEEKAMNKIL 189
                    566777888899999887655.5789999**********9997 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.8   1.8e-05      0.04       2     117 ..      19     126 ..      18     157 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.8e-05
   3Beta_HSD   2 vtGgaGFlGralvkeLvrleelkevrvlDlrespelleelskvnvkkviegDvtd..kdkleealegvdvvihlaslvdvagkltedeimkvnvkGTrn 98 
                 +tG +G lG+ l+k+L + +     +   l+ ++  ++e++ ++ ++v  gD+t+  +d+  + leg d vi  a+       ++ + i k+     + 
  EFC37346.1  19 ITGISGKLGEVLCKRLCDQGF----KCKGLVRDEDAKKEVQGLGCTDVFVGDLTKlqTDDFVKYLEGCDFVIDAAGS------TSGKDIEKIEFTSGKF 107
                 89***************9994....666777777777899*************973367899*******99987554......3334588999999999 PP

   3Beta_HSD  99 vleacvkagvrvlvYtSsa 117
                 + +a++k++v++ + +S++
  EFC37346.1 108 LAQAAMKSNVKKYISMSAV 126
                 9999999999998877765 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   2.8e-05     0.062       3      82 ..      17      96 ..      16     116 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.8e-05
                EEEETTTSHHHHHHHHHHHHSTTEEEEEEEETTCSTTTTTBHHHH.SSSS--S-BEBSSHHHHHHH-SEEEE-S-HHHHHH CS
      DapB_N  3 vavvGasGrmGkevvkaveeaedlelvaavdrkeselegkdagel.lglgklgvavtddleevlekadvliDFTtpeavle 82
                v ++G+sG++G+ ++k + + ++++  + v  ++ + e + +g   + +g l    tdd+ + le +d +iD    ++ ++
  EFC37346.1 17 VFITGISGKLGEVLCKRLCD-QGFKCKGLVRDEDAKKEVQGLGCTdVFVGDLTKLQTDDFVKYLEGCDFVIDAAGSTSGKD 96
                789***************99.9****9999999876666667643133447888888999999999******976665555 PP

>> ATPgrasp_ST  Sugar-transfer associated ATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   1.8e-05      0.04      53     126 ..      73     145 ..      39     157 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.8e-05
  ATPgrasp_ST  53 eafvkeleeg..vviKpakgsgGkGilviteredqdylkssgksalldelerhvsnilagLyslggkpdvalveel 126
                  ++fvk l eg  +vi +a + +Gk+i +i + +  ++l++ + + +++++   +s +    +s+g ++d ++ +++
   EFC37346.1  73 DDFVKYL-EGcdFVIDAAGSTSGKDIEKIEF-TSGKFLAQAAMKSNVKKYI-SMSAVGCDHFSSGERKDALVCDKC 145
                  4555555.3445*****************88.5566666666666777666.699999999********9998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       857  (0.0477997); expected 358.6 (0.02)
Passed bias filter:                      508  (0.028334); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.39u 0.28s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 1824.53
//
Query:       EFC37347.1  [L=631]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.037   13.4   1.9       0.57    9.6   0.0    2.8  3  DUF5305   Family of unknown function (DUF5305)


Domain annotation for each model (and alignments):
>> DUF5305  Family of unknown function (DUF5305)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.2    0.0057     1e+02     116     159 ..     202     244 ..     188     248 .. 0.64
   2 ?   -3.6   0.1      0.34   6.1e+03     116     133 ..     292     309 ..     272     317 .. 0.59
   3 ?    9.6   0.0   3.2e-05      0.57     116     170 ..     425     479 ..     413     492 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.0057
     DUF5305 116 gilliilgllaliglvvlirriiftsskaekyelelekilkeYd 159
                 ++l +i++ ++++g+  +  +   +  + +ky + l+k ++ Y+
  EFC37347.1 202 IALSSICIAFSILGILMFLISS-RAVYNSSKYTNILKKLFRIYG 244
                 3445556666655555554443.334446889999999999887 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 0.34
     DUF5305 116 gilliilgllaliglvvl 133
                   + iil+++ ++g+ vl
  EFC37347.1 292 STANIILVIINALGILVL 309
                 344455555555554444 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 3.2e-05
     DUF5305 116 gilliilgllaliglvvlirriiftsskaekyelelekilkeYdewIvkgslppd 170
                 g+ +ii+gl  +++++ l+++ i t+   ++ ++e  +il e+++  +++s+ ++
  EFC37347.1 425 GMSGIIVGLGLVGCIIGLTVMEIYTRVSYNEVRKEVVRILSECASQAIELSNDES 479
                 7789****************************************99999888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (631 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1628  (0.0908026); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 3727.74
//
Query:       EFC37348.1  [L=503]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.14   11.5   0.2       0.34   10.3   0.2    1.6  1  Sp38      Zona-pellucida-binding protein (Sp38)


Domain annotation for each model (and alignments):
>> Sp38  Zona-pellucida-binding protein (Sp38)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.2   1.9e-05      0.34      37     108 ..      62     133 ..      24     137 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 1.9e-05
        Sp38  37 sykchsvkiqrrglqselfiafqvnpfapgwkdlcnssldtedttnkrllkakdrieeffrkqveilkkkfe 108
                  y   sv  ++     e+ i+ +   + p  +++ n+sl  e++ n++l+kakd  +e  ++  eil  +++
  EFC37348.1  62 MYTDASVLEEEDSKRVEMVITKSNRRIVPLSESVDNGSLSYEKSFNEKLEKAKDAFQENRKRSLEILSVNMN 133
                 4555566667777889*********************************************99999987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1114  (0.062134); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.35s 00:00:01.02 Elapsed: 00:00:00.55
# Mc/sec: 2766.48
//
Query:       EFC37349.1  [L=606]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.4e-50  169.6   0.0    9.4e-50  168.8   0.0    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.3e-15   57.5   0.0    3.2e-15   56.2   0.0    1.7  1  PAS_9          PAS domain
    2.8e-09   37.0   0.0    5.7e-09   36.0   0.0    1.6  1  PAS            PAS fold
     0.0087   16.3   0.0      0.018   15.3   0.0    1.5  1  PAS_4          PAS fold
  ------ inclusion threshold ------
      0.038   13.4   0.3      0.073   12.5   0.3    1.4  1  HNOBA          Heme NO binding associated
       0.14   11.9   2.3        0.3   10.8   0.2    2.5  3  Pox_VLTF3      Poxvirus Late Transcription Factor VLTF3 like
       0.35   10.8   2.9       0.76    9.7   0.0    2.2  2  DUF3611        Protein of unknown function (DUF3611)


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.8   0.0   3.7e-53   9.4e-50       3     181 ..     361     557 ..     359     559 .. 0.95

  Alignments for each domain:
  == domain 1  score: 168.8 bits;  conditional E-value: 3.7e-53
  Guanylate_cyc   3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevavesk. 97 
                    ae++++vt +F+d+vgft++ss++ + e+v +Ln +++ fd l+++++++k+ktiGday ++ gl  +  +h ++++ +aLd +  +++ ++++  
     EFC37349.1 361 AEKFSDVTCFFSDMVGFTSISSKMGANELVGMLNAIVNGFDALTEKYDLEKIKTIGDAYFATGGLW-QTSDHPERVLMFALDTFYVIRTYNTSNIa 455
                    68899*************************************************************.999*****************999999844 PP

  Guanylate_cyc  98 ..................eglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellk.eeqfeltergevevkGkg 174
                                      +++++r+Gi+tG++vagviG+kk+ yd+wG+t+n+Asrmest+k+g++q+s++t e  +   + +++er  vevkGkg
     EFC37349.1 456 qqlrkidnldapdihkviPQIDIRIGINTGECVAGVIGTKKFAYDLWGDTINVASRMESTSKPGQVQISRSTFERVHdLPKLKFEER-FVEVKGKG 550
                    6899*********************************************************************99996666666665.79****** PP

  Guanylate_cyc 175 kletyfl 181
                    k+++y++
     EFC37349.1 551 KMQSYLV 557
                    *****87 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.2   0.0   1.3e-18   3.2e-15       2     103 ..     218     321 ..     217     322 .. 0.92

  Alignments for each domain:
  == domain 1  score: 56.2 bits;  conditional E-value: 1.3e-18
       PAS_9   2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk......kerevevvlirkngetfwvlltaspvkdddgelvg 94 
                 dg +++n++g i+ +N+aa r+ G +++evlg++++ lf  d + +++++ ++  + k        +++ev+  rkng++f++ +t+s    d++ +  
  EFC37349.1 218 DGAVMCNDKGDIEIFNPAASRIHGRQADEVLGRPFWILF--DTKYHDEIKSVMSLMIKgnhlnhAGETKEVEGLRKNGTKFPAIITISGTTYDSKVIYI 314
                 78899**********************************..999999999999999889999****************************888866665 PP

       PAS_9  95 iivilrDit 103
                   ++++Di+
  EFC37349.1 315 --CFIKDIS 321
                 ..******9 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.0   0.0   2.2e-12   5.7e-09       3     113 .]     209     320 ..     207     320 .. 0.95

  Alignments for each domain:
  == domain 1  score: 36.0 bits;  conditional E-value: 2.2e-12
                 HHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC...TTSSEEEEEEEEEEEEE CS
         PAS   3 lraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl...rdgrpihlevraspvrd 98 
                 +r++l+++ d+ ++ + +g+i  +N+aa ++ G +++evlg+++ +l+ +++++e ++ ++  ++ ++ ++age+++     ++g+++++ ++ s ++ 
  EFC37349.1 209 VRNMLNAAVDGAVMCNDKGDIEIFNPAASRIHGRQADEVLGRPFWILFDTKYHDEIKSVMSLMIKGNHLNHAGETKEVEglrKNGTKFPAIITISGTTY 307
                 799*********************************************************************99999889******************9 PP

                 TTEEEEEEEEEEEES CS
         PAS  99 aggeilgflgvlrdi 113
                  ++    ++++++di
  EFC37349.1 308 DSKV--IYICFIKDI 320
                 9886..699999997 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   7.2e-06     0.018       1      61 [.     213     273 ..     213     284 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 7.2e-06
       PAS_4   1 ldslpdalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvle 61 
                 l++  d+ +++++ g ++  N+aa ++ g++++e+lG++++ l+ +   +++ + +  +++
  EFC37349.1 213 LNAAVDGAVMCNDKGDIEIFNPAASRIHGRQADEVLGRPFWILFDTKYHDEIKSVMSLMIK 273
                 578899***********************************99988877777776666555 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.3   2.9e-05     0.073     193     221 .]     325     353 ..     319     353 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.9e-05
       HNOBA 193 esmkeleeekkrtdeLLysmiPkevAerL 221
                 ++++ l eekk +++LL +++P  vA++L
  EFC37349.1 325 KQNALLAEEKKNSENLLKNILPSAVAQKL 353
                 677889********************987 PP

>> Pox_VLTF3  Poxvirus Late Transcription Factor VLTF3 like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.56   1.4e+03      76     109 ..      47      79 ..      43      98 .. 0.75
   2 ?   10.8   0.2   0.00012       0.3      55     120 ..     146     214 ..     141     216 .. 0.88
   3 ?   -2.6   0.1       1.6     4e+03      67     109 ..     333     374 ..     317     381 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.56
   Pox_VLTF3  76 leiltgkrpdklssleeklikdiFdelteifdkl 109
                   ++ g  + +l++++ k     +del++ f   
  EFC37349.1  47 DDMIQGHGCSQLTNSTLKTCYG-LDELVKAFVLS 79 
                 5789999999999999998888.89999988443 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00012
   Pox_VLTF3  55 kvlkiLKelglkklyedvklIleiltgkrpdklssleeklikdiFdelteifdklvkk...nerknfin 120
                 +vl +L  + ++k+ ++v+++   l+ +++d+l+ +ee +   + ++l   +++ + +    + +n++n
  EFC37349.1 146 MVLTFLIHNSIEKTEQEVNQVRSLLNYVPVDNLDAKEELRTYVLHNSLPSLIHRNHTDsndDNVRNMLN 214
                 7999**************************************999999999999998855555555555 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.6
   Pox_VLTF3  67 klyedvklIleiltgkrpdklssleeklikdiFdelteifdkl 109
                 + ++  +l  +il     +kl+  e   +++ F ++t +f  +
  EFC37349.1 333 EKKNSENLLKNILPSAVAQKLKAGETFIAEK-FSDVTCFFSDM 374
                 4566667777777777777777777777777.77777777665 PP

>> DUF3611  Protein of unknown function (DUF3611)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   2.4      0.54   1.4e+03     141     173 ..     114     146 ..     102     156 .. 0.79
   2 ?    9.7   0.0    0.0003      0.76      65     133 ..     442     510 ..     434     527 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.54
     DUF3611 141 sqliqplDilvvqAntntilAhfvGlvvsLwLl 173
                 s+l + lDi+v  +++n++++ +v +++s++++
  EFC37349.1 114 SNLFTFLDIFVSSSSANLVISILVFVAASIMMM 146
                 466677899999999999999888888888764 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0003
     DUF3611  65 lfsifwafrytrlarrLraenpelrpkkaevlqllklGlivnlvGmllallgaeatvgvLlakalsqpq 133
                  f ++ ++   ++a++Lr+ ++ ++p   +v+ ++ + + +n    ++ ++g++ ++  L+  ++++  
  EFC37349.1 442 TFYVIRTYNTSNIAQQLRKIDNLDAPDIHKVIPQIDIRIGINTGECVAGVIGTKKFAYDLWGDTINVAS 510
                 6778889999**********************************************9999999988854 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (606 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1153  (0.0643092); expected 358.6 (0.02)
Passed bias filter:                      730  (0.0407162); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 3613.64
//
Query:       EFC37350.1  [L=1028]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-09   37.1  18.4    5.8e-09   35.9  18.2    1.8  1  zf-MYND   MYND finger


Domain annotation for each model (and alignments):
>> zf-MYND  MYND finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9  18.2   3.2e-13   5.8e-09       1      38 []     982    1024 ..     982    1024 .. 0.96

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 3.2e-13
                  -TTT--......B-SCE-TTTS-SEESSHHHHHHCHHHHCCCH CS
     zf-MYND    1 CavCgk.....aealkkCagCksvfYCskeCqradwksHkteC 38  
                  Ca C++      e+lk C++C +v+YC+++Cq +dw++Hk+eC
  EFC37350.1  982 CATCKNlcgekGEPLKSCSRCGKVKYCCRDCQVKDWQNHKPEC 1024
                  9999999998999999*************************** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1028 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1133  (0.0631937); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.86u 0.31s 00:00:01.17 Elapsed: 00:00:00.52
# Mc/sec: 5959.61
//
Query:       EFC37351.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-37  126.3  26.1    6.4e-09   35.4   0.0   10.7 12  DUF4116   Domain of unknown function (DUF4116)
     0.0056   15.6   1.8       0.71    8.7   0.0    3.3  4  mTERF     mTERF


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.37   3.3e+03      18      29 ..      21      34 ..      19      35 .. 0.73
   2 !    5.7   0.1    0.0014        12      20      46 ..      54      83 ..      48      86 .. 0.77
   3 !   15.2   0.6   1.5e-06     0.013       5      49 .]      91     138 ..      90     138 .. 0.85
   4 !   34.4   1.6   1.5e-12   1.3e-08       1      49 []     113     163 ..     113     163 .. 0.91
   5 !   28.9   0.6   7.9e-11   7.1e-07       1      41 [.     140     180 ..     140     215 .. 0.74
   6 !   22.0   0.0   1.1e-08   9.7e-05       1      29 [.     192     220 ..     192     223 .. 0.96
   7 ?   -0.1   0.0     0.085   7.6e+02      12      27 ..     229     244 ..     224     251 .. 0.80
   8 !   17.3   0.1   3.3e-07    0.0029      11      47 ..     253     290 ..     247     292 .. 0.87
   9 ?    1.5   0.0     0.028   2.5e+02      20      42 ..     314     339 ..     296     345 .. 0.69
  10 !    5.2   0.0    0.0019        17       4      44 ..     326     365 ..     324     370 .. 0.79
  11 !   35.4   0.0   7.1e-13   6.4e-09       3      49 .]     349     395 ..     347     395 .. 0.96
  12 !   32.3   0.2   6.6e-12   5.9e-08       2      43 ..     373     415 ..     372     442 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.37
     DUF4116 18 ylseeL..knDkei 29
                yl+e++  k+D+ +
  EFC37351.1 21 YLDERFewKCDRCL 34
                77777555999976 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0014
     DUF4116 20 seeLknDk...eivlkAvkqngtalsyase 46
                 ++Lk ++   ei+lkAv   +++ s +s+
  EFC37351.1 54 IDNLKDNRffsEIILKAVSYVPYVVSKCSP 83
                578999999999999999987777776665 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 1.5e-06
     DUF4116   5 vleavkkngsalkyls.eeLknDkeivlkAvk..qngtalsyaseeLr 49 
                 v e++++n s++++l  + ++nD+e +lk++   +++ +l  aseeL+
  EFC37351.1  91 VRELISRNVSCYNFLElPYYSNDRECLLKIIAntNYCQILGQASEELQ 138
                 6799**********744699************4445569*******97 PP

  == domain 4  score: 34.4 bits;  conditional E-value: 1.5e-12
     DUF4116   1 DrEivleavkkngs..alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE  l+++ + ++  +l  +seeL+nDk ++++A+++n ++++y+ e +r
  EFC37351.1 113 DRECLLKIIANTNYcqILGQASEELQNDKAFIMEAIEWNYKCYYYLKERMR 163
                 8999999999776657******************************98776 PP

  == domain 5  score: 28.9 bits;  conditional E-value: 7.9e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 D+ +++ea++ n ++++yl e++++D++i+l  v + g+ l
  EFC37351.1 140 DKAFIMEAIEWNYKCYYYLKERMRKDRDIALLVVSKEGYML 180
                 77799********************7777777777777654 PP

  == domain 6  score: 22.0 bits;  conditional E-value: 1.1e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkei 29 
                 D+E+v+ av +  sa+ ++s++Lk D+e+
  EFC37351.1 192 DKEVVKAAVMSSHSAIMFASSKLKEDREF 220
                 9***************************9 PP

  == domain 7  score: -0.1 bits;  conditional E-value: 0.085
     DUF4116  12 ngsalkylseeLknDk 27 
                 ++s ++y+   L++D+
  EFC37351.1 229 DPSLFRYAHLQLRSDI 244
                 7899999999999997 PP

  == domain 8  score: 17.3 bits;  conditional E-value: 3.3e-07
     DUF4116  11 kngsalkylseeLknDkeivlkAvkqngtalsyas.ee 47 
                 +++ +++y+ ++++ D+e vl+ +k+n+ +  ya  +e
  EFC37351.1 253 NFPQCIQYAISNIQGDIEYVLELIKINPLVVLYANwKE 290
                 67899***********************9999987555 PP

  == domain 9  score: 1.5 bits;  conditional E-value: 0.028
     DUF4116  20 seeLknDk...eivlkAvkqngtals 42 
                  eeL  D     +v++ ++++++ l 
  EFC37351.1 314 YEELDDDYaldSFVMRSIQRDPKTLQ 339
                 55555555555688888888887664 PP

  == domain 10  score: 5.2 bits;  conditional E-value: 0.0019
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 +v+  ++++++ l+ +   +k   ++v  Av+++g  l+ya
  EFC37351.1 326 FVMRSIQRDPKTLQLFH-LHKGCLQVVSHAVQIDGLTLEYA 365
                 78888888888888888.77888888888999999998887 PP

  == domain 11  score: 35.4 bits;  conditional E-value: 7.1e-13
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++v +av+++g+ l+y+  +++  k+iv kA+kqn++++++a++ Lr
  EFC37351.1 349 QVVSHAVQIDGLTLEYAERRIRMEKDIVRKACKQNPNSFKFADPTLR 395
                 67889***************************************998 PP

  == domain 12  score: 32.3 bits;  conditional E-value: 6.6e-12
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkq.ngtalsy 43 
                 ++iv +a+k+n++++k++++ L++D e+v + +++ ++t+  +
  EFC37351.1 373 KDIVRKACKQNPNSFKFADPTLRQDLEFVSELIEKvHPTIVFH 415
                 79******************************99646666555 PP

>> mTERF  mTERF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.14   1.2e+03      38      73 ..      55      90 ..      46     115 .. 0.77
   2 ?   -1.8   0.0      0.12   1.1e+03     239     266 ..     125     152 ..     113     156 .. 0.84
   3 !    8.7   0.0   7.9e-05      0.71     233     263 ..     247     277 ..     244     285 .. 0.88
   4 !    4.0   0.1    0.0022        20     155     190 ..     368     403 ..     328     439 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.14
       mTERF 38 kaLkslgasssdlteilskyPkiLskkleeslsksv 73
                + Lk + + s+ + + +s +P + sk   + ++ ++
  EFC37351.1 55 DNLKDNRFFSEIILKAVSYVPYVVSKCSPNMMKPYY 90
                567777777888888888888888877776666554 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.12
       mTERF 239 rfpqllglsaevlkkkleflvkemkkpl 266
                 ++ q+lg + e l++   f+++ ++++ 
  EFC37351.1 125 NYCQILGQASEELQNDKAFIMEAIEWNY 152
                 6889999999999999999999998876 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 7.9e-05
       mTERF 233 vakmvkrfpqllglsaevlkkkleflvkemk 263
                 + +++++fpq++ +++ +++  +e++++ +k
  EFC37351.1 247 ISELIVNFPQCIQYAISNIQGDIEYVLELIK 277
                 6789**********************98766 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.0022
       mTERF 155 elglskedvwkilkkyPeiLalsekklkkkiefLkk 190
                 ++ ++k+ v+k  k++P+ +++ + +l++ +ef ++
  EFC37351.1 368 RIRMEKDIVRKACKQNPNSFKFADPTLRQDLEFVSE 403
                 5668899*************************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       523  (0.0291706); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.71u 0.38s 00:00:01.08 Elapsed: 00:00:00.58
# Mc/sec: 2313.92
//
Query:       EFC37352.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-05   24.2   1.3      0.015   14.8   0.0    2.2  2  Esterase_phd  Esterase PHB depolymerase
  ------ inclusion threshold ------
      0.014   14.2   0.0      0.022   13.5   0.0    1.2  1  Pneumo_ncap   Pneumovirus nucleocapsid protein


Domain annotation for each model (and alignments):
>> Esterase_phd  Esterase PHB depolymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.3   0.00016       1.4      98     140 ..      45      87 ..      37     106 .. 0.86
   2 !   14.8   0.0   1.7e-06     0.015       5      87 ..     242     331 ..     238     339 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00016
  Esterase_phd  98 rvyvaGlsaGaaladllalhypdvfaavalhsGlalGeaadvi 140
                    + v+Gls+Ga +a      +       ++ +G ++ +a++  
    EFC37352.1  45 TLTVSGLSSGAYMATQFHVAFSKTVRGAGVFAGGPYYCAQNDF 87 
                   5679********************************9997643 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 1.7e-06
  Esterase_phd   5 lylppGarrgamplvvmlhGctqsv....eefaaGtrmnlladklGvvvlypeqslra..naqkcwnwyk.dtdraGrGeaavvvalvda 87 
                   +y+p   r     + v++hGc q      + +a+ +     a+   +++l+p+ +  a  n ++c +w+   +++    e + +va+ + 
    EFC37352.1 242 IYIPKACRTTQCRIHVVFHGCLQGRssigDVYAKNAGYLQHAELNNLIILFPQVTTLAkvNPNGCMDWWGyTNEKYATKEGEQLVAVRNM 331
                   7999999999999********9964112245777777777899999*******9976622678*****9955566666677767666555 PP

>> Pneumo_ncap  Pneumovirus nucleocapsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   2.5e-06     0.022     187     246 ..     199     261 ..     195     286 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.5e-06
  Pneumo_ncap 187 anrvlkdelkrykrldipkiarsfyelfekkvylidlfveyGka...lsssrtGskveslfvn 246
                  a +v++  lk y++  ip + + fy   +k  yl + f eyG     ++  +t  ++  +f +
   EFC37352.1 199 ASEVFSTLLKEYNGTSIPHVEENFYMFPQKDKYLASSFDEYGYIyipKACRTTQCRIHVVFHG 261
                  78899********************999999***********641114555566666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       435  (0.0242624); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1975.99
//
Query:       EFC37353.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.2e-24   84.5   5.6      3e-12   46.8   1.4    2.2  2  EF-hand_7     EF-hand domain pair
    8.2e-22   75.2  12.4    4.8e-06   26.1   1.4    5.0  5  EF-hand_6     EF-hand domain
    6.8e-21   72.2  15.4    6.9e-07   28.4   0.6    4.3  4  EF-hand_1     EF hand
    4.7e-14   51.2  16.3    8.4e-06   25.1   0.9    4.6  5  EF-hand_5     EF hand
    6.5e-12   45.1   9.0     0.0014   18.4   0.1    4.2  4  EF-hand_8     EF-hand domain pair
    3.6e-06   27.3   0.1     0.0029   17.9   0.0    2.9  2  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
  ------ inclusion threshold ------
      0.012   15.9   0.2        1.9    8.9   0.0    3.0  3  EF-hand_9     EF-hand domain
      0.059   13.2   0.7       0.76    9.7   0.1    2.8  3  EF-hand_10    EF hand


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.8   0.2     2e-13   4.6e-10       4      71 .]      22      90 ..      21      90 .. 0.90
   2 !   46.8   1.4   1.3e-15     3e-12       2      66 ..     124     187 ..     123     192 .. 0.95

  Alignments for each domain:
  == domain 1  score: 39.8 bits;  conditional E-value: 2e-13
   EF-hand_7  4 lkeaFkelDtdgdgyldkeellrllrkifqga.gegsklsdeelellfkefDtdkdGvisfdEFlklyr 71
                l+++Fk +D dg++ +dk+el  ++  +        s+++++ +++++  +D+d++G+isf EF ++++
  EFC37353.1 22 LYQVFKNYDLDGNNAIDKRELIPFFMDFLKVLgMDPSSITPDDVKKFMSGIDSDGNGTISFVEFTNWFK 90
                799*****************777988887776766677788************************9985 PP

  == domain 2  score: 46.8 bits;  conditional E-value: 1.3e-15
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEF 66 
                 e+l+ +F+++Dt+ dg++d++e+ ++l+ +f +++ g + s +++ ++f+ +Dtdk+G i+ +E 
  EFC37353.1 124 EVLQSIFRKYDTNVDGKIDRDEFDQFLTDLFKQFELGIP-SGDHVTYFFDVIDTDKSGGITINEI 187
                 68999**********************************.999*******************996 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.2   2.9e-07   0.00064       2      26 ..      22      46 ..      22      54 .. 0.87
   2 ?    0.8   0.0      0.28   6.2e+02      16      27 ..      59      70 ..      58      71 .. 0.89
   3 !   14.9   0.1   8.1e-06     0.018       5      28 ..      68      91 ..      64      95 .. 0.82
   4 !   26.1   1.4   2.1e-09   4.8e-06       2      28 ..     126     152 ..     125     160 .. 0.90
   5 !   18.4   0.0   6.4e-07    0.0014       4      27 ..     169     192 ..     166     196 .. 0.92

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.9e-07
   EF-hand_6  2 lreaFklfDkdgdGkidaeElrkal 26
                l+++Fk +D dg++ id+ El+ ++
  EFC37353.1 22 LYQVFKNYDLDGNNAIDKRELIPFF 46
                6799*****************8665 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.28
   EF-hand_6 16 kidaeElrkalr 27
                +i++++++k+++
  EFC37353.1 59 SITPDDVKKFMS 70
                59********97 PP

  == domain 3  score: 14.9 bits;  conditional E-value: 8.1e-06
   EF-hand_6  5 aFklfDkdgdGkidaeElrkalrk 28
                +   +D dg+G+i++ E+ +++++
  EFC37353.1 68 FMSGIDSDGNGTISFVEFTNWFKD 91
                55669***************9996 PP

  == domain 4  score: 26.1 bits;  conditional E-value: 2.1e-09
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalrk 28 
                 l+++F+++D++ dGkid++E+ ++l++
  EFC37353.1 126 LQSIFRKYDTNVDGKIDRDEFDQFLTD 152
                 789**********************95 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 6.4e-07
   EF-hand_6   4 eaFklfDkdgdGkidaeElrkalr 27 
                 ++F+ +D+d++G i+++E+  +lr
  EFC37353.1 169 YFFDVIDTDKSGGITINEIDVWLR 192
                 79*****************98888 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.4   3.5e-06    0.0079       3      27 ..      23      47 ..      21      49 .. 0.86
   2 !   22.2   0.4   2.9e-08   6.5e-05       1      28 [.      64      91 ..      64      92 .. 0.92
   3 !   28.4   0.6   3.1e-10   6.9e-07       2      28 ..     126     152 ..     125     153 .. 0.92
   4 !   15.1   0.1   5.4e-06     0.012       5      27 ..     170     192 ..     166     194 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3.5e-06
                HHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1  3 keiFrefDkDgdGkIdfeEfkellk 27
                 ++F+ +D Dg+  Id+ E++ +++
  EFC37353.1 23 YQVFKNYDLDGNNAIDKRELIPFFM 47
                689****************987765 PP

  == domain 2  score: 22.2 bits;  conditional E-value: 2.9e-08
                HHHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfkellkk 28
                ++k++++ +D Dg+G+I+f Ef +++k+
  EFC37353.1 64 DVKKFMSGIDSDGNGTISFVEFTNWFKD 91
                58999*******************9985 PP

  == domain 3  score: 28.4 bits;  conditional E-value: 3.1e-10
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 l+ iFr++D++ dGkId++Ef ++l++
  EFC37353.1 126 LQSIFRKYDTNVDGKIDRDEFDQFLTD 152
                 789********************9986 PP

  == domain 4  score: 15.1 bits;  conditional E-value: 5.4e-06
                 HHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   5 iFrefDkDgdGkIdfeEfkellk 27 
                 +F+++D+D++G I+++E   +l+
  EFC37353.1 170 FFDVIDTDKSGGITINEIDVWLR 192
                 7****************877766 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   3.2e-05     0.072       3      21 ..      24      42 ..      22      47 .. 0.91
   2 !   10.1   0.1   0.00021      0.47       8      22 ..      72      86 ..      65      90 .. 0.84
   3 !   25.1   0.9   3.7e-09   8.4e-06       1      24 [.     126     149 ..     126     150 .. 0.91
   4 ?   -2.8   0.1       2.4   5.5e+03       3       8 ..     152     157 ..     152     159 .. 0.78
   5 !   12.6   0.2   3.2e-05     0.071       5      20 ..     171     186 ..     168     189 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.2e-05
                HHHHHH-SS-SSCE-HHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeEL 21
                ++F+  Dl+g   I+k EL
  EFC37353.1 24 QVFKNYDLDGNNAIDKREL 42
                78****************9 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00021
                H-SS-SSCE-HHHHH CS
   EF-hand_5  8 iDlNgDGkIskeELk 22
                iD +g G+Is+ E+ 
  EFC37353.1 72 IDSDGNGTISFVEFT 86
                9*********99986 PP

  == domain 3  score: 25.1 bits;  conditional E-value: 3.7e-09
                 HHHHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIskeELktl 24 
                 l+  F++ D+N DGkI+++E+ ++
  EFC37353.1 126 LQSIFRKYDTNVDGKIDRDEFDQF 149
                 6788*****************987 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 2.4
                 HHHHHH CS
   EF-hand_5   3 dtFqai 8  
                 d+F+++
  EFC37353.1 152 DLFKQF 157
                 689998 PP

  == domain 5  score: 12.6 bits;  conditional E-value: 3.2e-05
                 HHHH-SS-SSCE-HHH CS
   EF-hand_5   5 FqaiDlNgDGkIskeE 20 
                 F+ iD++++G I++ E
  EFC37353.1 171 FDVIDTDKSGGITINE 186
                 9************999 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.014        32      32      52 ..      26      46 ..      25      48 .. 0.85
   2 !   17.8   0.3     1e-06    0.0022      10      52 ..      46      89 ..      45      92 .. 0.86
   3 !   18.4   0.1   6.3e-07    0.0014      26      53 ..     124     151 ..     114     153 .. 0.88
   4 !    8.3   0.1   0.00091         2      30      47 ..     169     186 ..     161     190 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.014
   EF-hand_8 32 frefDtdgdGkisfeEFcvll 52
                f+  D+dg+++i++ E + ++
  EFC37353.1 26 FKNYDLDGNNAIDKRELIPFF 46
                6777**********9998776 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 1e-06
   EF-hand_8 10 lrrilrilglkk.glseeevdilfrefDtdgdGkisfeEFcvll 52
                ++++l++lg+   ++++++v   ++ +D dg+G+isf EF + +
  EFC37353.1 46 FMDFLKVLGMDPsSITPDDVKKFMSGIDSDGNGTISFVEFTNWF 89
                677788888555****************************7655 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 6.3e-07
   EF-hand_8  26 eevdilfrefDtdgdGkisfeEFcvlle 53 
                 e ++++fr+ Dt+ dGki+ +EF ++l+
  EFC37353.1 124 EVLQSIFRKYDTNVDGKIDRDEFDQFLT 151
                 5689*******************77765 PP

  == domain 4  score: 8.3 bits;  conditional E-value: 0.00091
   EF-hand_8  30 ilfrefDtdgdGkisfeE 47 
                   f+ +Dtd++G i+ +E
  EFC37353.1 169 YFFDVIDTDKSGGITINE 186
                 569***********9888 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0    0.0026       5.9      58     111 ..      24      86 ..       2      87 .. 0.67
   2 !   17.9   0.0   1.3e-06    0.0029      17     109 ..      86     186 ..      84     190 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0026
  SPARC_Ca_bdg  58 wkFsklDtnsdkvlsksELaplraplvk...lehC......ikpflescDadkdkkislkEwc 111
                     F++ D + ++ ++k+EL p  +++ k   ++        +k+f++  D+d +++is  E++
    EFC37353.1  24 QVFKNYDLDGNNAIDKRELIPFFMDFLKvlgMDPSsitpddVKKFMSGIDSDGNGTISFVEFT 86 
                   459999999999999999999876544311134322222226889999999999999999986 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 1.3e-06
  SPARC_Ca_bdg  17 rdWlknlleelkereeekehlee.lekkeeeknlkeckepvawkFsklDtnsdkvlsksELaplrapl.......vklehCikpflescDadkdkki 105
                   ++W+k     l   +++k+++++ l +   ekn+++ +e ++  F k Dtn d+ +++ E ++  ++l       ++    ++ f++  D+dk + i
    EFC37353.1  86 TNWFKDAVLGLIPPSKKKKKKRTlLDSYLAEKNTTKQVEVLQSIFRKYDTNVDGKIDRDEFDQFLTDLfkqfelgIPSGDHVTYFFDVIDTDKSGGI 182
                   6899988888777666665554415667789999999************************998888722222222334556889999999999999 PP

  SPARC_Ca_bdg 106 slkE 109
                   + +E
    EFC37353.1 183 TINE 186
                   9988 PP

>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.37   8.3e+02      22      63 ..      48      90 ..      43      93 .. 0.77
   2 ?    2.6   0.1     0.077   1.7e+02      32      62 ..     120     150 ..     109     154 .. 0.69
   3 ?    8.9   0.0   0.00083       1.9       3      27 ..     170     194 ..     168     199 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.37
   EF-hand_9 22 dyLravtaqdpees...eLeelakelDPdgedasvdldtflrvmr 63
                d+L+  +  dp+     ++ ++ + +D dg+ +++ +  f    +
  EFC37353.1 48 DFLKVLGM-DPSSItpdDVKKFMSGIDSDGN-GTISFVEFTNWFK 90
                77777777.7777667789999999999999.9999888876655 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.077
   EF-hand_9  32 pees.eLeelakelDPdgedasvdldtflrvm 62 
                 ++ +  L++  +++D +   +++d d f + +
  EFC37353.1 120 TKQVeVLQSIFRKYDTNVD-GKIDRDEFDQFL 150
                 3344468999999996655.999999987766 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.00083
   EF-hand_9   3 vFevcDtqktGrVpvsrlidyLrav 27 
                  F+v Dt+k G +++ ++   Lr +
  EFC37353.1 170 FFDVIDTDKSGGITINEIDVWLREN 194
                 59****************9999976 PP

>> EF-hand_10  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.44     1e+03      25      47 ..      24      46 ..      22      50 .. 0.84
   2 ?    9.7   0.1   0.00034      0.76      25      49 ..     128     152 ..     124     153 .. 0.92
   3 ?   -1.1   0.0      0.79   1.8e+03      27      48 ..     171     192 ..     168     193 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.44
  EF-hand_10 25 kLFkkcDkSksgrLegeEieeFy 47
                ++Fk+ D   ++ ++  E+  F+
  EFC37353.1 24 QVFKNYDLDGNNAIDKRELIPFF 46
                79999999999999999987775 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00034
  EF-hand_10  25 kLFkkcDkSksgrLegeEieeFykl 49 
                 ++F+k D+  +g+++  E+ +F+  
  EFC37353.1 128 SIFRKYDTNVDGKIDRDEFDQFLTD 152
                 79********************976 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.79
  EF-hand_10  27 FkkcDkSksgrLegeEieeFyk 48 
                 F   D+ ksg +  +Ei   ++
  EFC37353.1 171 FDVIDTDKSGGITINEIDVWLR 192
                 6667888999999999988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       914  (0.0509789); expected 358.6 (0.02)
Passed bias filter:                      651  (0.0363099); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.40u 0.21s 00:00:00.61 Elapsed: 00:00:00.38
# Mc/sec: 1595.49
//
Query:       EFC37354.1  [L=355]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-05   25.2   0.2    1.9e-05   24.7   0.2    1.1  1  BCS1_N          BCS1 N terminal
     0.0093   16.5  62.8    1.8e+04  -24.0  62.8    3.4  1  KRTAP           Keratin-associated matrix
  ------ inclusion threshold ------
       0.52   10.4  58.7    1.8e+04  -23.0  58.7    3.4  1  Keratin_2_head  Keratin type II head


Domain annotation for each model (and alignments):
>> BCS1_N  BCS1 N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.7   0.2   3.2e-09   1.9e-05      16     131 ..      48     170 ..      33     178 .. 0.69

  Alignments for each domain:
  == domain 1  score: 24.7 bits;  conditional E-value: 3.2e-09
      BCS1_N  16 aslirrrflvsveissdDeaydwvlaWlsaqpasrrs.relsvetrtksrssdssaee.dededeeedg.....kkkkplrylPavgtthlfrykgrll 107
                  sl+ r+++ ++  s++   y w+  W s++p +++   +++   +t++ + ++++e+ +ed+ ++  +      ++ +++++P++g  h++  +   l
  EFC37354.1  48 GSLLFRWMFYQLNLSDTCIEYAWFSLWFSHHPYTKNGsTHVKPFQKTTKLRVNRTNEPkEEDSIAT--SnisemISNLKVNFVPSYG-IHILYRNSEPL 143
                 45577899999999999999***********98888755555555555554444444322222222..1345576678*********.7***99999*9 PP

      BCS1_N 108 avtRereekssdsetga...peetltl 131
                  v+ + ++++++++ ++    +e++++
  EFC37354.1 144 IVSISINTNQNNNAYNTeekTREDIVI 170
                 999888776666555543334555655 PP

>> KRTAP  Keratin-associated matrix
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -24.0  62.8         3   1.8e+04      38      38 ..     294     294 ..     224     355 .] 0.54

  Alignments for each domain:
  == domain 1  score: -24.0 bits;  conditional E-value: 3
       KRTAP  38 G 38 
                 G
  EFC37354.1 294 G 294
                 0 PP

>> Keratin_2_head  Keratin type II head
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -23.0  58.7         3   1.8e+04      84      98 ..     288     298 ..     218     355 .] 0.48

  Alignments for each domain:
  == domain 1  score: -23.0 bits;  conditional E-value: 3
  Keratin_2_head  84 glGfggGvglgfgag 98 
                     glG g G  lg+  g
      EFC37354.1 288 GLGLGLG--LGL--G 298
                     0000000..000..0 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       409  (0.0228122); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2287.08
//
Query:       EFC37355.1  [L=377]
Description: hypothetical protein NAEGRDRAFT_55502 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   5.3e-149  496.3   0.0   2.1e-148  494.3   0.0    1.7  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  494.3   0.0  1.2e-152  2.1e-148       2     407 .]       5     377 .]       4     377 .] 0.98

  Alignments for each domain:
  == domain 1  score: 494.3 bits;  conditional E-value: 1.2e-152
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 ++v+a+V+DnGs++++aG+ag+daP+av+ps++g+p++++ +      + yvgdea++kr+ l++++p+e+G+v++wd++e++w+h++++el+v peeh
  EFC37355.1   5 EDVQALVVDNGSGMCKAGFAGDDAPRAVFPSIIGRPKQKSIMVgmgnkDAYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH 103
                 689************************************998899**9*************************************************** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvev 194
                 p+llte+plnp+++rek+++i+fE+f vpa+y+a +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G++Lt++l+++l ++    
  EFC37355.1 104 PVLLTEAPLNPKANREKMTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMER---- 198
                 **********************************************************************************************8.... PP

       Actin 195 tprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligs 291
                                           ++s++t++e+e++++iKe++c+++ d+e+  + +++sss eksYeLPDg++i++g+eRf++pE+LF+p+ ig+
  EFC37355.1 199 --------------------------GYSFNTTAEREIVRDIKEKLCYIALDFEAemKVAAESSSVEKSYELPDGNVITVGNERFRCPEVLFQPNFIGM 271
                 ..........................9**************************996666677799********************************** PP

       Actin 292 esaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvs 390
                 e a         g++e ++++i +cd+d+r++L+ n+v++GG+++++g+ eR+ kel+++a++++k+k++ap+ erkys+WiGGSiLAsl+tfqq+w++
  EFC37355.1 272 EAA---------GVHETTFNSIGKCDIDIRKDLYGNVVLSGGTTMFEGIAERMTKELTAMAPASMKIKVVAPP-ERKYSVWIGGSILASLSTFQQMWIT 360
                 *99.........*************************************************************.************************* PP

       Actin 391 kqEYeEqGssvverkck 407
                 k+EYe+ G+ +v+rkc+
  EFC37355.1 361 KEEYEDAGPGIVHRKCF 377
                 ****************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       349  (0.0194657); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.35s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2202.90
//
Query:       EFC37356.1  [L=410]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.4e-68  228.9   0.0    9.8e-68  228.3   0.0    1.3  1  Thiolase_N     Thiolase, N-terminal domain
    1.7e-41  140.7   0.1      3e-41  139.9   0.1    1.4  1  Thiolase_C     Thiolase, C-terminal domain
    1.4e-05   24.8   0.7    6.5e-05   22.6   0.4    2.2  3  ketoacyl-synt  Beta-ketoacyl synthase, N-terminal domain
     0.0036   17.4   0.0       0.82    9.8   0.0    3.3  3  DUF2802        Protein of unknown function (DUF2802)
     0.0051   16.6   0.9       0.71    9.8   0.4    2.7  3  ACP_syn_III    3-Oxoacyl-[acyl-carrier-protein (ACP)] synthas
  ------ inclusion threshold ------
       0.02   15.1   0.0      0.048   13.8   0.0    1.7  1  ACP_syn_III_C  3-Oxoacyl-[acyl-carrier-protein (ACP)] synthas


Domain annotation for each model (and alignments):
>> Thiolase_N  Thiolase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  228.3   0.0   3.3e-71   9.8e-68       1     259 [.      16     272 ..      16     273 .. 0.94

  Alignments for each domain:
  == domain 1  score: 228.3 bits;  conditional E-value: 3.3e-71
                 EEEEEEEEE--EE..TTSTTTTS-HHHHHHHHHHHHHHHHTS-GGGCCEEEEEHSSCT.TSTSCHHHHHHHHTTS-TTSEEEEEEHGGGHHHHHHHHHH CS
  Thiolase_N   1 vvivsaartpigk..fggslkdlsaeeLlaealkallekagvdpeevdevivGnvlqa.gegqniarqaalkagipeevpavtvnkvcsSglkavalaa 96 
                 v+iv+  rtpig     gsl+d+  + Ll+ +l ++ ++ +v+++ev++vi+G v    ++g+n+ r a lkag p +vp v +n++c+S+ +av+ +a
  EFC37356.1  16 VYIVDCIRTPIGLgrNTGSLHDIHPVSLLSYVLDSVTSRCNVNKAEVEDVICGIVTPVkEQGANLPRLALLKAGYPVHVPGVQLNRMCGSSQQAVHFGA 114
                 89*********976689***************************************9999*************************************** PP

                 HHHHTTSHSEEEEEEEEESTTS-EEETCTTTTGGSSSSEEEEEHHHHHHTEETTTTSEHHHHHHHHHHHHT--HHHHHHHHHHHHHHHHHHHHTTTTTT CS
  Thiolase_N  97 qsiaageadvvvagGvEsmsnaptaestdvrsglklgdekakdllipdgladafneehmGltaenlakkykisReeqdefAvkshqkaaaaqkagkFkd 195
                 q+ia+g++d++va+GvE ms +p+  + d   +l + +++ k+l   +     ++  h G++ae +a++ykis++e def v+sh+ka ++ k+g +++
  EFC37356.1 115 QAIASGDVDMIVACGVEMMSVVPMGSDCDP--ELFQISATPKELKFGK---FPYKLLHQGVSAELIAEHYKISKKEIDEFSVESHRKAYESSKKGIYNS 208
                 *************************98665..5555555555555444...446789****************************************** PP

                 TBE-EEEEESSSEEEE-S-TTS-TT--HHHHHTS-BSSSTTSS-BTTSB--BEEEEEEEEEEEH CS
  Thiolase_N 196 eivPvkvkgkkgkktvdkdeairsevtaekLaklkpaFkkeGtvtAgnasqisDGaaavllmse 259
                 +i+P+kvk+ + ++ +++de+ir +v  ekL+klkp+Fk +G + A+nasqisDGaaavll+s 
  EFC37356.1 209 QILPIKVKKGETETWFKHDEGIRYPVDTEKLSKLKPVFKRDGVISAANASQISDGAAAVLLCSG 272
                 *********9999************************************************985 PP

>> Thiolase_C  Thiolase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.9   0.1     1e-44     3e-41       1     122 [.     280     401 ..     280     402 .. 0.99

  Alignments for each domain:
  == domain 1  score: 139.9 bits;  conditional E-value: 1e-44
                 ---SEEEEEEEEEE--GGGGGGHHHHHHHHHHHHHT--GGGESEEEE--SBHHHHHHHHHHHT--GGGBSTT--HHHH-B-TTTHHHHHHHHHHHHHHH CS
  Thiolase_C   1 lkplakirsyaevgvdpeilglgPayaikkvlkkagltvedidlfEinEAFaaqaLavakaldldlekvNvnGGaialGHPlGasGaRivvtllselkk 99 
                 lkp a++++ ++ g+dp ++  g ++a++k+l+k gl+++did+fEinEAFa+++La  k++++  +k+N nGGaia+GHPlGa+Ga ++++l++el++
  EFC37356.1 280 LKPRARVVTRISIGCDPVMMLDGVIPATRKALEKSGLSIDDIDVFEINEAFASVVLAWKKTFNVPDSKLNPNGGAIAMGHPLGATGAILMTKLVNELER 378
                 5899*********************************************************************************************** PP

                 CTTSEEEEEEEETTTEEEEEEEE CS
  Thiolase_C 100 eggklgvaalCigggqgvalvie 122
                  ++++g+ ++Cig g +va++ie
  EFC37356.1 379 TNKRYGLQSMCIGHGAAVATIIE 401
                 *********************98 PP

>> ketoacyl-synt  Beta-ketoacyl synthase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.4   2.2e-08   6.5e-05     174     205 ..     102     133 ..      92     150 .. 0.91
   2 ?   -1.7   0.0       0.6   1.8e+03     233     251 ..     255     273 ..     236     275 .. 0.81
   3 ?   -2.4   0.0      0.98   2.9e+03      94     111 ..     305     322 ..     294     349 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 2.2e-08
                    GGGHHHHHHHHHHHHHHTTS-SEEEEEEEE-- CS
  ketoacyl-synt 174 ACsSslvavhaavqslrsgeadvalaGGvell 205
                     C Ss  avh   q++ sg++d+++a+Gve++
     EFC37356.1 102 MCGSSQQAVHFGAQAIASGDVDMIVACGVEMM 133
                    7*****************************87 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.6
                    B-SB-BB-EEEEEEEEECH CS
  ketoacyl-synt 233 adGfvlGEGvGavvLkrle 251
                    a+   +++G++av+L + e
     EFC37356.1 255 ANASQISDGAAAVLLCSGE 273
                    4666789999999998765 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 0.98
                    HHHHHHHHHHTS-HHTCT CS
  ketoacyl-synt  94 eaawealedagltpeeld 111
                     a+++ale++gl+ +++d
     EFC37356.1 305 PATRKALEKSGLSIDDID 322
                    578999999999988765 PP

>> DUF2802  Protein of unknown function (DUF2802)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.27   8.1e+02      47      61 ..      49      63 ..      45      63 .. 0.90
   2 !    9.8   0.0   0.00027      0.82      38      60 ..     164     186 ..     163     187 .. 0.95
   3 ?    2.4   0.0     0.059   1.8e+02      29      54 ..     379     404 ..     369     407 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.27
     DUF2802 47 eelaeecgLsraEAe 61
                + ++++c+  +aE+e
  EFC37356.1 49 DSVTSRCNVNKAEVE 63
                7899*********98 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00027
     DUF2802  38 klvrqGasveelaeecgLsraEA 60 
                 kl++qG+s+e +ae   +s+ E+
  EFC37356.1 164 KLLHQGVSAELIAEHYKISKKEI 186
                 89********************8 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.059
     DUF2802  29 qsklYsqAiklvrqGasveelaeecg 54 
                 ++k+Y      +++Ga v  ++e+c+
  EFC37356.1 379 TNKRYGLQSMCIGHGAAVATIIENCN 404
                 5566666666799************6 PP

>> ACP_syn_III  3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.4   0.00024      0.71       3      39 ..      99     135 ..      97     138 .. 0.93
   2 ?    4.2   0.0     0.013        39      51      66 ..     259     274 ..     237     284 .. 0.82
   3 ?   -2.6   0.0       1.7   5.1e+03      50      62 ..     388     401 ..     365     407 .. 0.60

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00024
                  EE-GGGHHHHHHHHHHHHHHTTS-SEEEEEEEEEGGG CS
  ACP_syn_III   3 lnaaCsgfvyalsvAdaliesgaakrvLvigaetlsk 39 
                  ln  C +  +a++  +++i+sg +  ++ +g e +s 
   EFC37356.1  99 LNRMCGSSQQAVHFGAQAIASGDVDMIVACGVEMMSV 135
                  6889******************************996 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.013
                  TB-EEEEEEEEEEESS CS
  ACP_syn_III  51 lfGDGAgAvvleasee 66 
                    +DGA+Av+l  +e+
   EFC37356.1 259 QISDGAAAVLLCSGEK 274
                  5689****99987754 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.7
                  TTB-EEEE.EEEEE CS
  ACP_syn_III  50 vlfGDGAg.Avvle 62 
                  +  G GA+ A+++e
   EFC37356.1 388 MCIGHGAAvATIIE 401
                  44555554155555 PP

>> ACP_syn_III_C  3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.6e-05     0.048       1      63 [.     311     375 ..     311     400 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.6e-05
                    HHHTT--GGG-SEEEE-SSSHHHHHHHHHHHT--GGGB--TH..HHH-B-GGGHHHHHHHHHHHT CS
  ACP_syn_III_C   1 Lekagltpedidalvphqanlriidavakklglpeekvvvnl..deyGntsaasiplaLdeavee 63 
                    Lek+gl+ +did++ ++ a ++++ a+ k +++p+ k   n     +G+   a+  +++ ++v+e
     EFC37356.1 311 LEKSGLSIDDIDVFEINEAFASVVLAWKKTFNVPDSKLNPNGgaIAMGHPLGATGAILMTKLVNE 375
                    79**********************************99877644567777777777777777774 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       513  (0.0286129); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.43u 0.22s 00:00:00.65 Elapsed: 00:00:00.39
# Mc/sec: 3187.81
//
Query:       EFC37357.1  [L=292]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      3e-23   82.7   0.0    5.4e-23   81.9   0.0    1.4  1  NAD_binding_2   NAD binding domain of 6-phosphogluconate dehy
    2.7e-10   40.5   0.1    4.2e-10   39.9   0.1    1.2  1  NAD_binding_11  NAD-binding of NADP-dependent 3-hydroxyisobut
     0.0022   18.1   0.0     0.0048   17.0   0.0    1.6  1  Shikimate_DH    Shikimate / quinate 5-dehydrogenase


Domain annotation for each model (and alignments):
>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.9   0.0   9.1e-27   5.4e-23      10     151 ..       1     157 [.       1     165 [. 0.87

  Alignments for each domain:
  == domain 1  score: 81.9 bits;  conditional E-value: 9.1e-27
                    HHHHHHHHHHHTT-EEEEE-SSHHHHHHHHHTT...EEE-SSHHHHHHHC......SEEEE-SSSHHHHHHHHHSHCCC-....-TT-EEEE-S-- CS
  NAD_binding_2  10 MGsnmalnllkagykvavynrtkekveelvaeg...akaaesieelvasl......dvvitmvkagkavdevieglleal....kkgdilidgsts 92 
                    MG +ma++ll ++++v+vynrt+ k+ +lv+e    +++++s  e ++++       ++i m+ + +++ +v+++ l++l     +g+++i++st+
     EFC37357.1   1 MGLPMAKHLLINNHEVYVYNRTSTKAMDLVKEFpssCHVISSSDEDIQRVladqsiGIIISMLFDYQNIVDVVFQNLDKLggspLSGKVFIQMSTI 96 
                    *******************************97777555555555555555777899*********99999999955555444489********** PP

                    -HHHHHHHHHHHHHTT-EEEEEEEESHHHHHHHT-EEEEEEE-HHHHHHHHH..HHHHHEE CS
  NAD_binding_2  93 spedtrelakelkekglkfldaPVSGGeegAekGtLsimvGGseeafervkp..vleaiga 151
                    s+e++ +l +   + g +f++aPV G++  A +G+L++++G+s+e ferv++  vl+++g+
     EFC37357.1  97 SVEQSARLDELTGRCGGEFIEAPVLGTNTVAIAGKLQVLLGCSKELFERVESlnVLQNFGS 157
                    **************************************************97447888886 PP

>> NAD_binding_11  NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.9   0.1   6.9e-14   4.2e-10       5     119 ..     169     286 ..     166     289 .. 0.88

  Alignments for each domain:
  == domain 1  score: 39.9 bits;  conditional E-value: 6.9e-14
  NAD_binding_11   5 avKlvnnlllainlaaasEalvlaekaGldpekvlevinassgrsnalenklpqrvlsrdfdpgFaldlmlKDlglalelareagaplpllalae 99 
                      +Kl  n+l+a    +++  + l +  +ld++   ++++ s+   + ++ klp+ + ++  d +F+++ ++KDl+ + ++a++ ++++ l+++++
      EFC37357.1 169 KMKLSLNFLVASLTGVLANSISLVQSNDLDVNMYADIVRDSALYFKYFDMKLPRLLNHDYSDMNFSVNGIVKDLDCIEKMAEDSKVNTNLISTIK 263
                     6999*************************************************6555555588******************************** PP

  NAD_binding_11 100 qlyaaaaa...egggdaDhsaiv 119
                     +ly++a +   + +g++D++++ 
      EFC37357.1 264 NLYEQAGNrdeQIKGQEDFASVF 286
                     ***99865122556889998876 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0     8e-07    0.0048      24      77 ..       2      55 ..       1      72 [. 0.74

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 8e-07
                  HHHHHHHHHCCT-CEEEEEESSHHHHHHHHHHH.T.ET-EEEEGCGHHHHHHT-S CS
  Shikimate_DH 24 aelvakhLlakgvkkvvvaNRtlerakelaeel.kgeeiealkleelkellaead 77
                  +  +akhLl ++ + v v NRt ++a +l++e+ ++ ++   + e+++++la+  
    EFC37357.1  2 GLPMAKHLLINNHE-VYVYNRTSTKAMDLVKEFpSSCHVISSSDEDIQRVLADQS 55
                  55689****88887.******************4344444555566777776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (292 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       601  (0.0335211); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1877.83
//
Query:       EFC37358.1  [L=203]
Description: glutathione-s-transferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-16   59.6   0.2    5.5e-16   58.6   0.2    1.5  1  GST_C_3   Glutathione S-transferase, C-terminal domain
    1.2e-07   31.9   0.1    2.5e-07   30.9   0.1    1.5  1  GST_N     Glutathione S-transferase, N-terminal domain
    5.1e-05   23.4   0.1    0.00011   22.3   0.1    1.7  1  GST_C     Glutathione S-transferase, C-terminal domain
    9.9e-05   22.7   0.1    0.00054   20.3   0.1    2.0  2  GST_N_3   Glutathione S-transferase, N-terminal domain
     0.0014   18.6   0.0      0.003   17.5   0.0    1.7  1  GST_C_2   Glutathione S-transferase, C-terminal domain
     0.0037   18.0   0.0     0.0064   17.2   0.0    1.4  1  GST_N_4   Glutathione S-transferase N-terminal domain
  ------ inclusion threshold ------
      0.088   12.2   0.1        0.3   10.4   0.0    1.8  2  TraE      TraE protein


Domain annotation for each model (and alignments):
>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.6   0.2   2.1e-19   5.5e-16       2      97 ..      97     195 ..      96     197 .. 0.90

  Alignments for each domain:
  == domain 1  score: 58.6 bits;  conditional E-value: 2.1e-19
                 HHHHHHHCCCC..SHCHHH.HHHHHHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHHTCC.CC-HHHHHHHHHHHTSHHHHHHH CS
     GST_C_3   2 Dlhhpiaklly..dqkeea.ekkkefleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleeaeal.kkfpklkalyervearpkikaYl 96 
                 +l++++a++++    +e   ++kk fle  ++++l+++ek+l+++g+g+l+ +k+T+AD++l++++ +l++ e + ++f ++ + +e ++a+p+ ++Y+
  EFC37358.1  97 ELFNKYARVFFiaP-EETReQEKKVFLEGPVKTILGALEKILEENGDGHLIKGKFTWADFVLLDMVYALQFKEVDlSQFTHIIKSKEVLKAHPRFQDYV 194
                 68899999999743.3333599*********************99999************************6566**********************8 PP

                 C CS
     GST_C_3  97 e 97 
                  
  EFC37358.1 195 T 195
                 5 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   0.1   9.8e-11   2.5e-07       3      76 .]       5      73 ..       3      73 .. 0.85

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 9.8e-11
                EEEESSSTSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTT...S-SSEEEET.TEEEESHHHHHHHHHH CS
       GST_N  3 ltlysirgsprahrirlllaakgveyevvpldfeageekspellklnpl...gkvPaLedn.gkkltESraIleYiar 76
                + ++ ++g  r++ ++l +  ++v+y+vv ++        +e+   +p    g++P+L +n ++++ ++ aI++Y+a+
  EFC37358.1  5 IVYFAGPG--RSELLKLIAHVANVDYKVVGITK-------DEWPTHKPHtryGQMPYLKVNdKLTIYQTYAIARYLAQ 73
                56899999..9999999999************4.......445555555555*********99*************96 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.1   4.5e-08   0.00011       8      81 ..     102     176 ..      63     194 .. 0.86

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 4.5e-08
                 HHHHHHSTTHHHHHHHHHH.HHHHHHHHHHHHHHHHH..TSSSSSTTSSCHHHHHHHHHHHHHHHHTTTTTTTTSHH CS
       GST_C   8 illlfyvkaeekkeelvde.alekvaevlsaleeelk..kqdylvGdkltlADialvpilnwlqrlglafgqekfpn 81 
                 ++ +f++ +ee++e++++  ++  v+ +l ale+ l+  ++++l+  k+t+AD++l++ +  lq  +++++  +f +
  EFC37358.1 102 YARVFFIAPEETREQEKKVfLEGPVKTILGALEKILEenGDGHLIKGKFTWADFVLLDMVYALQFKEVDLS--QFTH 176
                 566777777777776666526677*********************************99999988888875..5554 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.1   2.1e-07   0.00054      14      71 ..      18      75 ..      14      82 .. 0.89
   2 ?   -0.4   0.0      0.63   1.6e+03      21      44 ..     163     189 ..     160     191 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 2.1e-07
                HHHHHHHT--EEEE---TTTTHHHHHHH-TT--SSEEE.TTS-EEESHHHHHHHHHHHH CS
     GST_N_3 14 rlaLnekglpvevvevtpgehdeellaknplgkvPvLe.ddgealtdSlaIidyLeely 71
                +l+ ++ +++++vv +t++e  ++ ++ +++g++P+L+  d   ++ + aI++yL ++ 
  EFC37358.1 18 KLIAHVANVDYKVVGITKDE-WPTHKPHTRYGQMPYLKvNDKLTIYQTYAIARYLAQQG 75
                578999**********9999.7999************737788************9985 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.63
                 T--EEEE---TTTT...HHHHHHH-TT CS
     GST_N_3  21 glpvevvevtpgeh...deellaknpl 44 
                  l++++v+++++ h   + e+l+ +p+
  EFC37358.1 163 ALQFKEVDLSQFTHiikSKEVLKAHPR 189
                 578999999999987778888888776 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   1.2e-06     0.003      11      67 ..     126     194 ..      86     196 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.2e-06
                 CCHCHHHCTTT---SS...CTTCS--HHHHHHHHHHHHH..HHHHHS-..........---TT-HHHHHHH CS
     GST_C_2  11 ldaaldaleahLadsp..flfGdqptlaDialapflvrl..raagpgf..........direaypnlraWl 67 
                 ++  l ale++L+      l  +++t+aD++l  +++ l  + +  ++          +  +a+p++++++
  EFC37358.1 126 VKTILGALEKILEENGdgHLIKGKFTWADFVLLDMVYALqfKEV--DLsqfthiikskEVLKAHPRFQDYV 194
                 55667788888887766669999**********65554422222..222245666666999*******997 PP

>> GST_N_4  Glutathione S-transferase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   2.5e-06    0.0064      13      83 ..      24      97 ..      17     111 .. 0.68

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 2.5e-06
     GST_N_4 13 agipyelepssn.e...m.haspkgklPfielngelliadsefiieflkekgvdld..aelseeqkadaralkalvee 83
                a+++y+++  ++ e     +  + g++P++++n++l+i  +  i ++l ++g dl   ++ +++q   ++ ++a ++e
  EFC37358.1 24 ANVDYKVVGITKdEwptHkPHTRYGQMPYLKVNDKLTIYQTYAIARYLAQQG-DLYpkDNIEATQ---TEEYVAAIDE 97
                555665554443322122355789********9999****************.444335666665...5666666665 PP

>> TraE  TraE protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.41     1e+03      54      74 ..      55      75 ..      53      80 .. 0.87
   2 ?   10.4   0.0   0.00012       0.3     112     154 ..      91     132 ..      76     141 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.41
        TraE 54 ikkpftvsaasadaeYleqmt 74
                ++ ++t+ +++a a+Yl+q +
  EFC37358.1 55 VNDKLTIYQTYAIARYLAQQG 75
                78899999*********9987 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00012
        TraE 112 laeeaerikksnvssvFypesievdpktltvevrGtlktfvgd 154
                 +++  +++  ++ + vF+++ +e+ +++++v+ +G  kt++g+
  EFC37358.1  91 YVAAIDELF-NKYARVFFIAPEETREQEKKVFLEGPVKTILGA 132
                 444448888.8999**************************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       668  (0.0372581); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1327.23
//
Query:       EFC37359.1  [L=1124]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.3e-18   65.3   0.9    3.2e-16   59.6   0.3    3.3  3  BTB       BTB/POZ domain
    3.1e-12   46.5   3.8    4.3e-10   39.6   0.5    3.4  3  BACK      BTB And C-terminal Kelch
  ------ inclusion threshold ------
       0.45   10.2  16.0        1.6    8.4  16.0    1.9  1  DUF5349   Family of unknown function (DUF5349)
        0.8    9.8   6.0         37    4.5   0.0    4.5  4  TetR_C_8  Transcriptional regulator C-terminal region


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.29   1.3e+03       3      18 ..     528     543 ..     526     548 .. 0.86
   2 !   59.6   0.3     7e-20   3.2e-16      21     108 ..     579     664 ..     574     667 .. 0.95
   3 ?    2.0   0.0     0.052   2.3e+02      80     110 ..     668     698 ..     662     699 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.29
                 HHHHHTTTS-EEEEET CS
         BTB   3 elresgelcDvtlvvg 18 
                 +l+es+ ++D+t+vvg
  EFC37359.1 528 KLFESEIMSDLTIVVG 543
                 68999**********9 PP

  == domain 2  score: 59.6 bits;  conditional E-value: 7e-20
                 EEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHHHHHHH CS
         BTB  21 kefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlkkaceeflk 108
                  efk+h+a+L+ar +yF++lf s+ +++  +  ++ +d  p++f+ lL+f Y++ ++i+   n+  +L++ d l ++ +k++c e++k
  EFC37359.1 579 VEFKVHRAILCARCEYFSKLFHSQ-MKDCMQGYLKFPDKRPDDFKCLLDFFYSAVININ-HFNAFGVLKLSDELGVQIVKEKCIEYVK 664
                 58**********************.99999999*************************7.9**********************99986 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.052
                 CGGGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  80 seenleelLaaadllqiprlkkaceeflkqs 110
                 s +n+ ++L+  ++ ++++l k c+e+l+++
  EFC37359.1 668 SADNVFDVLEESSFHNFDELRKYCKEYLEEN 698
                 47899***********************986 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       3.6   1.6e+04      63      82 ..      36      54 ..      36      66 .. 0.66
   2 !   39.6   0.5   9.6e-14   4.3e-10       3      77 ..     674     747 ..     672     751 .. 0.93
   3 !    6.1   0.0    0.0026        12      74     102 ..     913     941 ..     889     942 .. 0.72

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3.6
        BACK 63 feavlkWvkhdeeerkkhlp 82
                +e +l+W+++  e r++++ 
  EFC37359.1 36 YELALDWCRKFDE-RESAVD 54
                6789999998876.665554 PP

  == domain 2  score: 39.6 bits;  conditional E-value: 9.6e-14
        BACK   3 gilefAeaysceeLaeaakefilknfeevlkseeFleLskeqllellssdeLnvesEeevfeavlkWvkhdeeer 77 
                 ++le ++ ++ +eL++++ke++++n ++++ se Fl+++ke l++ll+sd++    E ++f av+ W kh+  +r
  EFC37359.1 674 DVLEESSFHNFDELRKYCKEYLEENANQMFFSESFLNITKETLIDLLKSDKI-HLGELDIFIAVVIWGKHQLIHR 747
                 57788999********************************************.668**************98765 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0026
        BACK  74 eeerkkhlpelLekvRlpllspeyLkevv 102
                  ++ +k l ++L +vR+p+l+p +L e+v
  EFC37359.1 913 CQQLAKLLYDILHNVRFPTLDPIELYEFV 941
                 456788999*************9998887 PP

>> DUF5349  Family of unknown function (DUF5349)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4  16.0   0.00037       1.6     164     282 ..     387     507 ..     375     524 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00037
     DUF5349 164 ssnannsnnentlfnsasfstsyepsnkspvltsstsssassydsseFdyilPsssaassstsatssssnnslntnvstsaslsgdllddlpva.ptas 261
                 + +   +nn+ +lf+  + s    ps +  + tss+sss+ s+ ++  + + P+++ a sst a++  s++ + + v+t++++ ++ + ++p    t+ 
  EFC37359.1 387 HWQTLLPNNKLQLFKREQLSM-TLPSASTTAVTSSSSSSTPSTVTTPSSTLTPTTTSA-SSTLASTAASASGATSIVVTATTSVTTPTTAVPKLgVTG- 482
                 444556777778888887765.678888888888888888888899999999**9999.788888888999999999999999999999999873444. PP

     DUF5349 262 slvg....dlsstetvsnlsasqal 282
                 ++ g    ++  ++t+s ++++++ 
  EFC37359.1 483 LTTGtssaSSARSRTISIGKPNSST 507
                 4434333355556677777666654 PP

>> TetR_C_8  Transcriptional regulator C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.23     1e+03       4      73 ..     258     322 ..     255     328 .. 0.70
   2 ?    2.1   0.0     0.048   2.1e+02      31      77 ..     593     635 ..     584     636 .. 0.79
   3 ?    1.4   0.4     0.075   3.4e+02      11      52 ..     681     723 ..     670     745 .. 0.67
   4 ?    4.5   0.0    0.0083        37      14      48 ..     893     927 ..     890     934 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.23
                 HHHHHHHHHHHHHTHHHHHHHHHH-.THHHHHHHHHHHHHHHHHHHHHH-TT--S-HHHHHHHHHHHHHH CS
    TetR_C_8   4 qegllklfeyikenkdfyknllssngresfekylkelikelilkvieelsegkelseedkefiadfysyg 73 
                  +++++l+++++ n++ +++l+ s     + ++  + +++l+l+ + ++    +  +++++++++++  g
  EFC37359.1 258 SKFFKRLCKIVASNSRGLETLILSIT--DLSSQHLDTFSNLLLEELPNIL---SNWKQQSKYVSRIFDTG 322
                 57899999999999999999998884..4444556777777777776666...33356777877777665 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.048
                 HHHHHHHHHHHHHHHHHHHHHH-TT--S-HHHHHHHHHHHHHHHHHH CS
    TetR_C_8  31 esfekylkelikelilkvieelsegkelseedkefiadfysygfvgv 77 
                 e f k +++ +k++++++++  +     +++d + + df+ ++++ +
  EFC37359.1 593 EYFSKLFHSQMKDCMQGYLKFPD----KRPDDFKCLLDFFYSAVINI 635
                 67888888888888888884444....56799**********99975 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.075
                 HHHHHHTHHHHHHHHHH-..THHHHHHHHHHHHHHHHHHHHHH CS
    TetR_C_8  11 feyikenkdfyknllssn.gresfekylkelikelilkvieel 52 
                 f+ ++e ++++k  l++n ++  f + + +++ke +++ +++ 
  EFC37359.1 681 FHNFDELRKYCKEYLEENaNQMFFSESFLNITKETLIDLLKSD 723
                 6667777777777777762456678888888888888887443 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.0083
                 HHHTHHHHHHHHHH-.THHHHHHHHHHHHHHHHHH CS
    TetR_C_8  14 ikenkdfyknllssngresfekylkelikelilkv 48 
                 +k++k+ + ++++ + ++sf ++l +l+++++ +v
  EFC37359.1 893 LKQKKERILKIVNYTHDKSFCQQLAKLLYDILHNV 927
                 789999************************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1124 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1240  (0.0691617); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.98u 0.31s 00:00:01.29 Elapsed: 00:00:00.51
# Mc/sec: 6659.14
//
Query:       EFC37360.1  [L=364]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
        1.2    9.1   4.9        2.4    8.1   4.9    1.4  1  Serglycin  Serglycin


Domain annotation for each model (and alignments):
>> Serglycin  Serglycin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   4.9   0.00014       2.4      89     112 ..      62      86 ..      42      95 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00014
   Serglycin  89 edy.sgsgsGsGsGsGsgsgsgflt 112
                 +++  g   GsGsGsGs+s  g++ 
  EFC37360.1  62 SNVsNGDSGGSGSGSGSSSSVGYSD 86 
                 3441445557999999999988865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (364 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       685  (0.0382063); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 2446.00
//
Query:       EFC37361.1  [L=312]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-21   75.3   7.1    5.7e-21   75.3   7.1    1.8  2  DUF2306   Predicted membrane protein (DUF2306)


Domain annotation for each model (and alignments):
>> DUF2306  Predicted membrane protein (DUF2306)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.4      0.24   4.3e+03     127     138 ..      61      72 ..      50      77 .. 0.72
   2 !   75.3   7.1   3.2e-25   5.7e-21       2     147 .]     113     286 ..     112     286 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.24
     DUF2306 127 ayavlsllawvp 138
                 +y++l +++wv 
  EFC37361.1  61 VYWLLIFAGWVA 72 
                 567777777764 PP

  == domain 2  score: 75.3 bits;  conditional E-value: 3.2e-25
     DUF2306   2 vlHialalvalllGalqlvkrlrakrpklHrlaGrvyvlavllaalsglflsvyatgglvlllgflllallwlvftvlalvai..rrrd.......... 88 
                 ++H   +++ ll+G+lq+   +r++   +H+++G+++ + v++  + gl+l  y++gg+ +++ f ll+l+w+v++  al+ +   +++          
  EFC37361.1 113 IVHAIGGILCLLIGILQFQDVIRRRVMIIHKIIGYIFSACVFIGFVGGLWLIPYSVGGVNTKVAFSLLSLIWIVTLGMALLYVtfAHKNplvkhlpkgd 211
                 68***********************999************************************************9997665226777999999999* PP

     DUF2306  89 .faaHrawmirsYalalaavtlrlvllvlil...............lvgedfetayavlsllawvpnlvvaelli 147
                  ++ Hr+wmir ++  +aa+tlr++l ++                 + + + +++y   ++la   nl++ e++i
  EFC37361.1 212 rIQRHREWMIRCFSSVCAAITLRIYLFLFAGfyiagnpnlsdtsygILDAAQKEVYGASAWLAVSGNLIISEIYI 286
                 *************************877776999***********99999********************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (312 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2018.84
//
Query:       EFC37362.1  [L=261]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       945  (0.0527079); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1610.89
//
Query:       EFC37363.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       524  (0.0292264); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 1977.47
//
Query:       EFC37364.1  [L=954]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-62  210.9   0.0      2e-62  210.9   0.0    2.5  3  Pkinase          Protein kinase domain
    9.6e-37  126.7   0.2    4.9e-36  124.3   0.0    2.1  2  Pkinase_Tyr      Protein tyrosine kinase
    1.7e-09   37.7   0.2    4.5e-09   36.4   0.2    1.8  1  Myb_DNA-binding  Myb-like DNA-binding domain
    1.4e-05   24.6   0.0    5.6e-05   22.6   0.0    2.0  2  Kinase-like      Kinase-like
  ------ inclusion threshold ------
      0.015   15.3   0.0      0.035   14.0   0.0    1.6  1  APH              Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.2      0.49   1.8e+03      40      98 ..     417     474 ..     402     516 .. 0.58
   2 ?   -1.1   0.8      0.27   9.5e+02     204     234 ..     517     547 ..     480     596 .. 0.50
   3 !  210.9   0.0   5.7e-66     2e-62       4     264 .]     643     914 ..     640     914 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.49
                 HHH.HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HH CS
     Pkinase  40 kke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslsee 98 
                 +++ k + +Ei+ +k+  h++ ++  e  ++ +e+   ++++++    +++e+k++++e+
  EFC37364.1 417 ESKtKGYESEINQMKNAIHDYDIKNNERNKRFREI--AVQFLRERAERERIEDKKKVNEK 474
                 22236677777777777777765555544443333..34444444445555555555555 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.27
                 HHHHHHHHTHHHHHHHCTSHH...HHHTTS- CS
     Pkinase 204 ekvekeldqlekilkilgetkeklpeaseis 234
                 ek++k++++  + lk  + t+++ +  ++++
  EFC37364.1 517 EKQKKNIQKQRQQLKKEQITTNDAEFIRKLE 547
                 2222222222222222222233333333333 PP

  == domain 3  score: 210.9 bits;  conditional E-value: 5.7e-66
                 EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.....HHHHHHHHHHHHHSCTTB--EEEEEEE.SSEEEEEEE--TTEBHHHHHHHHSS-- CS
     Pkinase   4 leklGeGsfGkVykaveketgkivAvKkikkekakkkke.....kkvlrEikilkklkhpnivrlyevfee.kdelylvleyveggeladllerkgsls 96 
                 ++ lG+G+f++Vyka++ ++ k vA+K+ + + + k+++     k+vlrE++i ++++h++++++y++f   +++++ vley+eg +l+ ++++++ ++
  EFC37364.1 643 MKMLGKGGFSEVYKAYDLTDFKVVACKIHQLNPNWKEHRkenyiKHVLRECQINQSINHEKLIKMYDTFVFdNNTFVTVLEYCEGADLDLYIKKHQRVP 741
                 688************************99876555444445778***********************99852667779********************* PP

                 HHHHHHHHHHHHHHHHHHHHTT..EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS...BCTTTSCGGGS-HHHH.......TTSCBSHHHHHHHH CS
     Pkinase  97 eeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtseYlAPEvl.......keneyskkvDvWsl 183
                 e+eak+i++qi++gl+yl +++  +iH DlKp+NiL+d++g++KitDFGl+k ++++++   +++  gt +Yl+PE            ++s+kvDvWs+
  EFC37364.1 742 EREAKNIISQIFSGLNYLCQQKqrVIHYDLKPANILFDKDGNIKITDFGLSKIMDEEESielTSQGAGTYWYLPPECFynpsgegPPPKISNKVDVWSA 840
                 ******************966556**********************************9**9999*************998765333778********* PP

                 HHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 184 GvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 Gvi++++l+g+ pf    ++ +++k+l +      i++ t++ +p +  +seeak++++++l+ +++kR+ ++ l ++ yl
  EFC37364.1 841 GVIFFQMLYGTKPFG---NNLSQQKILSE----GTIVNATQVGFPDKPAVSEEAKEFIRRCLTHEMSKRPDVKTLYNDAYL 914
                 ***************...44445566766....567888999******************************999998875 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2      0.24   8.5e+02      67     104 ..     478     514 ..     423     539 .. 0.67
   2 !  124.3   0.0   1.4e-39   4.9e-36       4     256 ..     643     909 ..     641     911 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.24
                  EEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHH CS
  Pkinase_Tyr  67 lgvctkeepllivteyvkgGdLlkfLrkkekekltlkd 104
                  +g +t  ++ l v e  + G+L + L+++e++ +t kd
   EFC37364.1 478 IGTIT-YQKGLDVYEVWQDGTLFQQLKENENRITTEKD 514
                  34444.34446688888899999999988444444444 PP

  == domain 2  score: 124.3 bits;  conditional E-value: 1.4e-39
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEE....STTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE.SSSSEEEEEE--TTEBHHHHHHHTC CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtl....keeateeekeelleeakimkklkhpnivkllgvct.keepllivteyvkgGdLlkfLrkke 96 
                   k lG+G f++V++++    ++ k v + + +l    ke+ +e+  +++l+e++i ++++h++++k++   + ++++ + v+ey++g dL+ +++k+ 
   EFC37364.1 643 MKMLGKGGFSEVYKAYDL--TDFKVVACKIHQLnpnwKEHRKENYIKHVLRECQINQSINHEKLIKMYDTFVfDNNTFVTVLEYCEGADLDLYIKKH- 737
                  689************988..4555555555555333234555555889999*****************99987999999*****************9. PP

                  TTTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.......EEHH CS
  Pkinase_Tyr  97 kekltlkdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.......ftsk 185
                   +++  ++  +++ q+ +G++yL ++k  ++H dl   N+L +++  +ki+DfGL++ + ++++ + ++++   + +++pE++ + +       ++ k
   EFC37364.1 738 -QRVPEREAKNIISQIFSGLNYLCQQKqrVIHYDLKPANILFDKDGNIKITDFGLSKIMDEEESIELTSQGAGTYWYLPPECFYNPSgegpppkISNK 834
                  .999999****************765444****************************998888999999999999999******9989999999**** PP

                  HHHHHHHHHHHHHHTTSSGTTTTS.HHHHHHHH..HHTTEE..S-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 186 sDvWsfGvllwEiftlgespypgl.kneevlek..lkegkr..lekpekcpeelyelmkkcweedpeeRptfselv 256
                   DvWs Gv+ + ++  g +p+ +  +++++l+   + + ++   +    ++ee +e++++c+++++++Rp+ ++l 
   EFC37364.1 835 VDVWSAGVIFFQMLY-GTKPFGNNlSQQKILSEgtIVNATQvgFPDKPAVSEEAKEFIRRCLTHEMSKRPDVKTLY 909
                  ************998.99999776588888764225566661245555699********************99986 PP

>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.4   0.2   1.3e-12   4.5e-09       1      45 [.     135     184 ..     135     185 .. 0.91

  Alignments for each domain:
  == domain 1  score: 36.4 bits;  conditional E-value: 1.3e-12
                      CSSSBHHHHHHHHHHHHHHTTC....HHHHHHHHT.SS-HHHHHHHHHHH CS
  Myb_DNA-binding   1 rgkWteeEdelLleavkkhGnr....WkkIaerlg.gRtekqcrsrwrny 45 
                      r ++t+eEd+++ e+++kh ++    W+ +a++    Rt++q++sr+ ++
       EFC37364.1 135 RRRFTPEEDKKIKEGIAKHKKDnnidWDGVAKYACiERTKEQIKSRYMRM 184
                      679*****************4447***********************875 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       1.2   4.3e+03     222     244 ..     471     493 ..     460     497 .. 0.82
   2 !   22.6   0.0   1.6e-08   5.6e-05     161     257 ..     762     861 ..     734     880 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.2
  Kinase-like 222 knktkmthkldaWqlGlviyriw 244
                   n+  +t+++ ++q Gl +y +w
   EFC37364.1 471 VNEKSITIGTITYQKGLDVYEVW 493
                  46778999999**********99 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 1.6e-08
  Kinase-like 161 qakglvhgkftvdnllldekgglmlggf..taLvragtkvvl.sevekg..faPpEllgsrggytrknktkmthkldaWqlGlviyriwclklPltla 253
                  q++ ++h ++++ n+l+d++g +++++f  ++++   ++  l s+ + +  + PpE + +  g  +    k++ k+d+W  G+  + +   + P+++ 
   EFC37364.1 762 QKQRVIHYDLKPANILFDKDGNIKITDFglSKIMDEEESIELtSQGAGTywYLPPECFYNPSG--EGPPPKISNKVDVWSAGVIFFQMLYGTKPFGNN 857
                  7788**********************993346777888888845544443378***9999888..55799*******************999999987 PP

  Kinase-like 254 teea 257
                   ++ 
   EFC37364.1 858 LSQQ 861
                  7665 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   9.8e-06     0.035     163     200 ..     761     796 ..     708     798 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 9.8e-06
                 SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-EEEE CS
         APH 163 elptvllHgDlhpgNllvdpddgrvtGviDfedaglgp 200
                 +++++++H Dl+p N+l+d+d++    + Df+++++++
  EFC37364.1 761 QQKQRVIHYDLKPANILFDKDGNIK--ITDFGLSKIMD 796
                 57899**************554444..99999999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (954 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3589  (0.200178); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                       108  (0.00602376); expected 17.9 (0.001)
Passed Fwd filter:                        40  (0.00223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.36u 0.39s 00:00:01.75 Elapsed: 00:00:00.58
# Mc/sec: 4989.56
//
Query:       EFC37365.1  [L=440]
Description: hypothetical protein NAEGRDRAFT_81943 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-19   68.3   1.4    2.5e-06   27.1   0.0    4.4  4  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    2.3e-09   37.7   0.9     0.0034   18.0   0.1    5.6  6  RCC1      Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   1.9e-06     0.017       2      26 ..      69      93 ..      68      96 .. 0.91
   2 !   17.6   0.0   2.8e-07    0.0025       1      30 []     125     154 ..     125     154 .. 0.97
   3 !   27.1   0.0   2.8e-10   2.5e-06       3      30 .]     238     265 ..     236     265 .. 0.89
   4 !    4.4   0.0    0.0037        33       4      18 ..     292     306 ..     290     308 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.9e-06
      RCC1_2  2 ksvsaGdyHscaLtedGeVlcWGsN 26
                 +vs+G+++ ++L++dG +++ G N
  EFC37365.1 69 DQVSIGSDFLLILLSDGSLYTMGIN 93
                59*********************77 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 2.8e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 Vk +s+G++ s++ t+++e+++ G N++GQ
  EFC37365.1 125 VKMISSGGFYSIVATRNDELYGIGANDYGQ 154
                 788**************************9 PP

  == domain 3  score: 27.1 bits;  conditional E-value: 2.8e-10
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++ +G++H +aL+ dG+++c+GsNs+ Q
  EFC37365.1 238 QLKSGAFHIVALLKDGRIFCCGSNSRDQ 265
                 5669********************9855 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.0037
      RCC1_2   4 vsaGdyHscaLtedG 18 
                 + +G++++++L +d 
  EFC37365.1 292 INCGSDFTLFLKSDR 306
                 78*********9986 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.5   1.3e+04      36      48 ..      67      79 ..      62      81 .. 0.77
   2 ?    2.2   0.0     0.032   2.9e+02      32      47 ..     120     135 ..      84     138 .. 0.50
   3 !    9.8   0.0   0.00013       1.2       2      50 .]     142     195 ..     141     195 .. 0.82
   4 ?   -0.2   0.0      0.17   1.6e+03      32      50 .]     233     249 ..     211     249 .. 0.76
   5 !   18.0   0.1   3.8e-07    0.0034       1      50 []     252     302 ..     252     302 .. 0.79
   6 ?   -2.8   0.0       1.2     1e+04       8      20 ..     355     367 ..     355     392 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.5
                -EEEEEEETTEEE CS
        RCC1 36 rvvkvacGddhtv 48
                ++ +v+ G+d+ +
  EFC37365.1 67 HIDQVSIGSDFLL 79
                6789****99876 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.032
                 GTTS-EEEEEEETTEE CS
        RCC1  32 lsgnrvvkvacGddht 47 
                 l++++v+ +++G++++
  EFC37365.1 120 LKDKPVKMISSGGFYS 135
                 3444666666666666 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00013
                 TEEEEEE--GGGTTSSSS-...--EEEEEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt...esvlvPtkveglsgn..rvvkvacGddhtval 50 
                 +++y+ G ndyGq    ++   +s+  P k+   +++   +++++c  +++v++
  EFC37365.1 142 DELYGIGANDYGQFSVYSSsthKSNANPLKIDYGKKEgdIITHMTCCFSFSVVI 195
                 689*************55534466677****88887788999999999999986 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.17
                 GTTS-EEEEEEETTEEEEE CS
        RCC1  32 lsgnrvvkvacGddhtval 50 
                 +s  +v +  +G++h val
  EFC37365.1 233 PS--PVYQLKSGAFHIVAL 249
                 33..8999999****9997 PP

  == domain 5  score: 18.0 bits;  conditional E-value: 3.8e-07
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgn..rvvkvacGddhtval 50 
                 dGr++++G+n++ qLG   + s+   ++v +l+++  + + + cG+d+t++l
  EFC37365.1 252 DGRIFCCGSNSRDQLGSVYNTSRKGIQEV-FLDNQieKPIGINCGSDFTLFL 302
                 9****************777555111444.5555589************986 PP

  == domain 6  score: -2.8 bits;  conditional E-value: 1.2
                 E--GGGTTSSSS- CS
        RCC1   8 GrndyGqLGlgtt 20 
                 G+n+   LG g +
  EFC37365.1 355 GNNNTFTLGDGED 367
                 7777777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (440 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       353  (0.0196888); expected 358.6 (0.02)
Passed bias filter:                      301  (0.0167884); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 2697.90
//
Query:       EFC37366.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.2e-45  152.3   1.9    1.1e-44  152.1   1.9    1.1  1  Pyrophosphatase  Inorganic pyrophosphatase


Domain annotation for each model (and alignments):
>> Pyrophosphatase  Inorganic pyrophosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  152.1   1.9   6.2e-49   1.1e-44       1     160 []      57     255 ..      57     255 .. 0.93

  Alignments for each domain:
  == domain 1  score: 152.1 bits;  conditional E-value: 6.2e-49
                      EEEEE-TTCSEEEEEETTT...........TEEEEEEE-SSSB-BSSEEEEETT--BT....................CCBEETSSSEEEEEES CS
  Pyrophosphatase   1 vvvEiprgsnaKyeidkee...........gklrldrvlftskgypanYGfipqTled....................telkGDgDPlDvlvlg 63 
                      +v Eip+++ +K+e++++e           gklr      ++ g+p+nYG++pqT+ed                      ++GD+DP+Dv++++
       EFC37366.1  57 FVNEIPMHTLKKMEVNTKEqfnpiiqdekkGKLREFTYRLDAGGIPFNYGMLPQTWEDpkklihvpfgqvkdgvyqptVAVQGDNDPIDVVEIS 150
                      689***************************9****9*****************************************999************** PP

                      SS---TTEEEEEEEEEEEEEEETTEEEEEEE..EEETTSGGG.T...T-SSGGGSTHHHHHHHHHHHHHTTTTSCCT-SE.EEE.EEEEHHHHH CS
  Pyrophosphatase  64 eeplspgevvevkvlGvlamiDegetDdKii..avpvkdprl.k...kindiedlpgllleeiehfFetykdlegkkknv.kve.ewkdkeeAe 149
                      +++l++gev+++kv G+lamiDege+D+K+i  +v+++++++ +   +++di d+p+  +++i ++F++yk+ +gk +n+  ++ ++ dk++A+
       EFC37366.1 151 DVALEMGEVYKIKVFGILAMIDEGEMDWKVIgrVVSESETSTqQpdeDLQDIYDIPKGKINDIIDWFRMYKTTDGKPENHfGFNtTVLDKAYAK 244
                      *******************************98787774433223348999999********************9966888************* PP

                      HHHHHHHHHHH CS
  Pyrophosphatase 150 kvieeaheryk 160
                      ++i+++h++++
       EFC37366.1 245 HIINQTHKHWS 255
                      *********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       537  (0.0299515); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.43
# Mc/sec: 1793.18
//
Query:       EFC37367.1  [L=576]
Description: hypothetical protein NAEGRDRAFT_81944 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-32  110.7  33.5    1.1e-23   83.8  15.3    3.0  3  MFS_1     Major Facilitator Superfamily
    1.2e-09   37.6   4.5    1.2e-09   37.6   4.5    2.7  3  Sugar_tr  Sugar (and other) transporter
    4.5e-05   22.0   0.8    0.00012   20.7   0.8    1.7  1  MFS_3     Transmembrane secretion effector
  ------ inclusion threshold ------
      0.025   15.0   0.2      0.091   13.2   0.2    1.9  1  DUF4094   Domain of unknown function (DUF4094)
       0.07   13.3   0.9       0.67   10.1   0.8    2.7  2  DUF2371   Uncharacterised conserved protein (DUF2371)


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.2     0.016        56     194     230 ..      61     113 ..      41     132 .. 0.58
   2 !   83.8  15.3     3e-27   1.1e-23      22     273 ..     117     415 ..      91     420 .. 0.68
   3 !   30.0  10.7   6.9e-11   2.5e-07      58     172 ..     439     555 ..     435     571 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.016
       MFS_1 194 aplvpawkallkdpvl..........w.......illialllfffgfsglltll 230
                 +p +   + +++d++l          w       il+++ll++f++++++++++
  EFC37367.1  61 KPKLL-CGCIRTDRYLgfielkpgitWvhitcfyILVVILLSMFVFINAMSSYV 113
                 33333.567777776666565555555555554445555555555555555544 PP

  == domain 2  score: 83.8 bits;  conditional E-value: 3e-27
       MFS_1  22 alaedlgispse...igllltlyalgaavaslplGrlsdrf.GrrrvlllglllfalglllllfasslwlllvlrvlqGlgagalfpagaaliadwfpk 116
                 +l  + +  +++   +g l     l  +++ l++G+l+d + Gr+ v+++g+l++++gl+l +fa ++w l++ r++ ++ga++  ++  a++ d+++ 
  EFC37367.1 117 YLRGTVN-RKDQgklAGDLSFYNELCILAFGLIWGVLTDILrGRKFVYMIGFLFMGIGLFLYTFAETIWQLIIYRIIFAIGAASTSSMLTAIVGDYVKN 214
                 4555555.4444333666777788899*************736666************5555599********************************** PP

       MFS_1 117 eergraigllsagfslGailgpllggllasslg...........Wravfyilaivsllafvlfllll.................peepperkrkspkee 187
                 ++rg+a gll+++++lGa++ +l+   +  ++               +f+i+a+++++a+   ++++                 +              
  EFC37367.1 215 KDRGKASGLLGLASGLGAVVSALACLKIPLWIQsadptistgqaGMIAFMIMAFFCIIAMCALMIFFkgrifpicdskqereatR-------------- 299
                 ********************98887744433335557777765555679999999999955333444566666555444443332.............. PP

       MFS_1 188 e...........kgtgpaplvp........awkallkdpvlw...illialllfffgfsg....lltllply....lqevlgls...glllaglllall 253
                 +              +++++++        +w+ l+  p      +l++a +++ f+  g    ++t+++l+    + + ++ s   +   +g++++++
  EFC37367.1 300 RemaessdceeeDDEERFNIKKsfirfkniIWEGLFVAP--AkrpSLILAYISG-FVARGdsilITTFITLWvsqqMIDIHDSSkadATARGGTISGIC 395
                 033455555554223444444433334444455555555..1555555555555.47777778888888887555556666666***77********** PP

       MFS_1 254 alvgailallagrlsdrlgr 273
                 + +++i+a+++g ++d   r
  EFC37367.1 396 QTFALIAAPFVGIFADLRFR 415
                 ***************76333 PP

  == domain 3  score: 30.0 bits;  conditional E-value: 6.9e-11
       MFS_1  58 rfGrrrvlllglllfalglllllfa.sslw.lllvlrvlqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggllasslgWravf 154
                 +++r  v+ +  +++++g ++l+f       ++++  +l G+g+ +++  +++l+++ +p + rg++ g+++++ ++G++++  +gg+l + +  +++f
  EFC37367.1 439 KMSRLIVMAIVSAISGVGYTMLSFLtDVTGgFVYLPIALIGIGEIGVIICSQILVTAESPSKVRGSVSGIFTLFGAAGILVATKVGGYLFDDWKPSGPF 537
                 68777799999999999966777753334457999999************************************************************* PP

       MFS_1 155 yilaivsllafvlfllll 172
                 ++ +++ + +f++ + ++
  EFC37367.1 538 LFYGVLNFALFIISIGFI 555
                 ***********9866666 PP

>> Sugar_tr  Sugar (and other) transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   4.5   3.3e-13   1.2e-09      63     257 ..     146     345 ..     134     356 .. 0.81
   2 ?   -0.9   0.0      0.16   5.7e+02       4      73 ..     346     413 ..     343     418 .. 0.68
   3 !    5.3   8.0     0.002       7.2      71     166 ..     438     533 ..     433     563 .. 0.71

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 3.3e-13
                 HHHHHHHHHHT.THHHHHHHHHHHHHHHHHHHH-TTTTSS-TGGGGGHHHHHHHHHHHHHHHHHHHHTTS-SCCHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Sugar_tr  63 slfagllgdrf.GRkkslliaavlfvigavlqaaakgknsvevlivgRvlvGigvGlasvlvPmyisEiApkklRgalvslyqlaitfGilvaaifglg 160
                 +l+ g l+d++ GRk +++i+ +++ ig +l  +a+   ++++li+ R++  ig+  +s + +  ++ + + k Rg+  +l  la  +G +v+a   l+
  EFC37367.1 146 GLIWGVLTDILrGRKFVYMIGFLFMGIGLFLYTFAE---TIWQLIIYRIIFAIGAASTSSMLTAIVGDYVKNKDRGKASGLLGLASGLGAVVSALACLK 241
                 4777888888769***********************...9*******************************************************9999 PP

                 H.HTSS-........TTHHHHHHHCCHHHHHHHHHHGGGS---HHHHHHTT-HH.HHHH.HHHH.HHHCHHHHHHHHHHHHHHHHHHH.....HTTHHH CS
    Sugar_tr 161 l.nktsn........adgwrillglqlvpallllilllflPESPrylvekgkee.eake.vlak.lrgeedadrelaeekdsleaeqeeekaswkells 247
                 +   +++        + g+  ++ ++++  +++++l++f+     + +   k+e ea++  +a+ ++ ee++d+e  ++k+s+ +    +++ w+ l+ 
  EFC37367.1 242 IpLWIQSadptistgQAGMIAFMIMAFFCIIAMCALMIFFK-GRIFPICDSKQErEATRrEMAEsSDCEEEDDEERFNIKKSFIRF---KNIIWEGLFV 336
                 976666689****9999***********************9.56677766666655543133332444466666666666555554...4788888888 PP

                 HSH...HHHH CS
    Sugar_tr 248 sktvrqrlli 257
                      ++ li
  EFC37367.1 337 APAK-RPSLI 345
                 7663.44333 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.16
                 HHHHHHHHHHHHHHCGGGTHHHHHHHHTSTT--SHHHHHH...HHHHHHHTHHHHHHHHHHHHHHHHHHT CS
    Sugar_tr   4 vaalggllfgYdtgvigafltllkfaknfglsksksskeessvlsglivsiflvGaiiGslfagllgdrf 73 
                 +a+++g++   d+ +i +f+tl   + +     ++ssk++++ + g i +i +  a+i + f+g+++d  
  EFC37367.1 346 LAYISGFVARGDSILITTFITLWVSQQMID--IHDSSKADATARGGTISGICQTFALIAAPFVGIFADLR 413
                 566777777777778888888877444444..44444555578888889999888888888888888854 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.002
                 HHTTHHHHHHHHHHHHHHHHHHHH-TTTTSS-TGGGGGHHHHHHHHHHHHHHHHHHHHTTS-SCCHHHHHHHHHHHHHHHHHHHHHHH.HHHHTSS- CS
    Sugar_tr  71 drfGRkkslliaavlfvigavlqaaakgknsvevlivgRvlvGigvGlasvlvPmyisEiApkklRgalvslyqlaitfGilvaaifg.lglnktsn 166
                  +++R  +++i+++++ +g  +  + ++  +   +++   l+Gig  ++ +++ +++   +p k+Rg + +++ l+ ++Gilva+ +g + +++ + 
  EFC37367.1 438 RKMSRLIVMAIVSAISGVGYTMLSFLTDV-TGGFVYLPIALIGIGEIGVIICSQILVTAESPSKVRGSVSGIFTLFGAAGILVATKVGgYLFDDWKP 533
                 56777777888888888887666666633.4444444567999998888888889998899**********************98775144466665 PP

>> MFS_3  Transmembrane secretion effector
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.8   3.3e-08   0.00012      56     144 ..     140     224 ..     137     249 .. 0.88

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 3.3e-08
       MFS_3  56 LPifllsilaGalaDnfdrRkvllavqlllalvsvlltvlaalgllspwlllaltlligiGaalndPaWqAsvgelvkrrdvpaAvaLn 144
                 L i+ + ++ G+l+D++  Rk++ ++  l +   ++l ++a     + w l+++ ++ +iGaa ++    A+vg+ vk++d  +A  L 
  EFC37367.1 140 LCILAFGLIWGVLTDILRGRKFVYMIGFLFMGIGLFLYTFAE----TIWQLIIYRIIFAIGAASTSSMLTAIVGDYVKNKDRGKASGLL 224
                 7788999***************99999988888888877775....68******************************99987776665 PP

>> DUF4094  Domain of unknown function (DUF4094)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   2.5e-05     0.091       5      53 ..     266     316 ..     263     328 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.5e-05
     DUF4094   5 vllLcvasflagll.ftnRlwtvp.sdiirqs.keelkl.vsedcdskdaesr 53 
                 ++++c+++ +a ++ f++R+   p  d  +++  ++ ++  s+dc+++d e+r
  EFC37367.1 266 MAFFCIIAMCALMIfFKGRIF--PiCDSKQEReATRREMaESSDCEEEDDEER 316
                 678999999988765999*98..5334444443344455499****9887777 PP

>> DUF2371  Uncharacterised conserved protein (DUF2371)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.8   0.00019      0.67      44     125 ..      94     183 ..      78     185 .. 0.60
   2 ?   -1.7   0.0      0.84     3e+03      50      67 ..     267     294 ..     256     326 .. 0.48

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00019
     DUF2371  44 lllGllvllvGiamavlgywpkk...aklaseekssssstaesssekl....gllarfleqylysdkl.kvlGPlimGiGiflfiCanav 125
                 +l+ +l+++     a+ +y  ++    +++++++ + +++ +  +e +    gl+  +l++ l  +k+  ++G l mGiG+fl+  a+++
  EFC37367.1  94 ILVVILLSMFVFINAMSSYVFEAylrGTVNRKDQGKLAGDLSFYNELCilafGLIWGVLTDILRGRKFvYMIGFLFMGIGLFLYTFAETI 183
                 44444444444444555555555333233333333334444443333355666677777777777765269*************999887 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.84
     DUF2371  50 vllvGiamavlgywpkk..........a 67 
                   +  iam+ l  + k           +
  EFC37367.1 267 AFFCIIAMCALMIFFKGrifpicdskqE 294
                 3333455555554444444444433331 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1061  (0.0591779); expected 358.6 (0.02)
Passed bias filter:                      514  (0.0286686); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.53
# Mc/sec: 3249.12
//
Query:       EFC37368.1  [L=160]
Description: hypothetical protein NAEGRDRAFT_74922 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.7e-18   64.1  11.6    4.9e-09   36.3   0.3    4.0  4  LRR_4     Leucine Rich repeats (2 copies)
    1.4e-13   50.4   5.3    1.7e-05   24.5   1.3    3.6  3  LRR_8     Leucine rich repeat
    1.5e-13   50.6   0.1    1.3e-06   28.0   0.1    2.1  2  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
        0.2   12.3   9.2    1.1e+02    4.0   0.0    5.0  5  LRR_1     Leucine Rich Repeat
       0.42   10.8   4.9         29    5.0   0.0    4.1  4  LRR_6     Leucine Rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.4   1.4e-08   5.1e-05       1      42 [.       9      49 ..       9      51 .. 0.91
   2 !   36.3   0.3   1.4e-12   4.9e-09       1      42 [.      54      94 ..      54      96 .. 0.92
   3 !   23.4   0.6   1.5e-08   5.5e-05       2      37 ..      77     114 ..      77     118 .. 0.81
   4 ?    2.5   0.0     0.059   2.1e+02      16      29 ..     126     139 ..     120     145 .. 0.84

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 1.4e-08
                SS--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGG CS
       LRR_4  1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeL 42
                +n + L Ls N++  i++l++l +L+ L+L +N +i++l++L
  EFC37368.1  9 KNCKRLALSTNCIDRIGGLQGLVSLEILSLARN-QIKRLENL 49
                689999***66*******************888.***99988 PP

  == domain 2  score: 36.3 bits;  conditional E-value: 1.4e-12
                SS--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGG CS
       LRR_4  1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeL 42
                p Le L+Ls N+lt++ + ekl++Lk+L++ gNn+i++ +e+
  EFC37368.1 54 PTLEQLWLSYNNLTSLAGVEKLKKLKVLYC-GNNKISSWSEI 94
                679***************99**********.999**998775 PP

  == domain 3  score: 23.4 bits;  conditional E-value: 1.5e-08
                 S--EEE--SS---E-S-...HHH-TT--EEE-..-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdL.sgNnlit 37 
                 +L+vL+++nN++++++    l+ lp+L+e+ L +gN +++
  EFC37368.1  77 KLKVLYCGNNKISSWSEidrLKDLPDLEEI-LlTGN-PLE 114
                 79***************655556******8.54888.554 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.059
                 -S-HHH-TT--EEE CS
       LRR_4  16 iplleklpnLkeLd 29 
                 i+ l+ lp+Lk+Ld
  EFC37368.1 126 IEVLRRLPSLKKLD 139
                 5566669****997 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   6.8e-09   2.4e-05      19      61 .]       3      43 ..       2      43 .. 0.93
   2 !   24.5   1.3   4.7e-09   1.7e-05       1      61 []      54     113 ..      54     113 .. 0.90
   3 ?    0.4   0.0      0.16   5.6e+02      45      55 ..     129     139 ..     125     139 .. 0.56

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 6.8e-09
                TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8 19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                ++ ++++n k L Ls N+++++  g ++gL sL+ L L +N++
  EFC37368.1  3 TTVSQMKNCKRLALSTNCIDRI--GGLQGLVSLEILSLARNQI 43
                567889****************..7****************98 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 4.7e-09
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 p+L+ L Ls N+ltsl     ++l++LkvL+ +nN++++  + + + +Lp L+++ L+gN+L
  EFC37368.1  54 PTLEQLWLSYNNLTSLAG--VEKLKKLKVLYCGNNKISSwSEIDRLKDLPDLEEILLTGNPL 113
                 68999***********86..467****************555589***************97 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.16
                 GTT--S-.EEE CS
       LRR_8  45 fsgLpsLrsLd 55 
                 ++ LpsL++Ld
  EFC37368.1 129 LRRLPSLKKLD 139
                 45566666554 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.1   3.6e-10   1.3e-06      47     115 ..      14      81 ..       3      84 .. 0.92
   2 !   24.9   0.0   3.3e-09   1.2e-05      86     161 ..      74     154 ..      73     159 .. 0.88

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 3.6e-10
       LRR_9  47 idlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkl 115
                 + ls n i ++ g+  l  l++l+l+ n+i r+ e+l+ v P+le+l l+ n+l++la ++ l +lk l
  EFC37368.1  14 LALSTNCIDRIGGLQGLVSLEILSLARNQIKRL-ENLDAVAPTLEQLWLSYNNLTSLAGVEKLKKLKVL 81 
                 57999*************************998.79*************************99999977 PP

  == domain 2  score: 24.9 bits;  conditional E-value: 3.3e-09
       LRR_9  86 vlPnleelvltnnelqeladldPlaslkklellsllknpvtnk.....keyrlyviyklkqlrlldfrkvklkereeaekl 161
                  l +l+ l   nn++ + +++d l +l++le + l  np+ ++     +++r  v+ +l++l+ ld r   l+ere+ae +
  EFC37368.1  74 KLKKLKVLYCGNNKISSWSEIDRLKDLPDLEEILLTGNPLEKNtkdagENWRIEVLRRLPSLKKLDGRPFDLAEREQAEGV 154
                 5778999999****************************998652233368****************************865 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.8   6.5e+03       3      13 ..      12      22 ..      10      28 .. 0.64
   2 ?    3.6   0.1      0.04   1.4e+02       1      17 [.      32      48 ..      32      52 .. 0.83
   3 ?    4.0   0.0     0.031   1.1e+02       2      14 ..      56      68 ..      55      72 .. 0.86
   4 ?    3.9   0.1     0.032   1.2e+02       1      12 [.      77      88 ..      77     100 .. 0.82
   5 ?    2.9   0.1     0.067   2.4e+02       2      13 ..     103     114 ..     102     138 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.8
       LRR_1  3 rhLdLsnnpll 13
                ++L Ls n+++
  EFC37368.1 12 KRLALSTNCID 22
                56667777774 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.04
       LRR_1  1 nLrhLdLsnnpllglpp 17
                +L+ L L +n++ +l++
  EFC37368.1 32 SLEILSLARNQIKRLEN 48
                69********9977665 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.031
       LRR_1  2 LrhLdLsnnpllg 14
                L+ L Ls+n+l++
  EFC37368.1 56 LEQLWLSYNNLTS 68
                999*******975 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.032
       LRR_1  1 nLrhLdLsnnpl 12
                +L++L+ +nn +
  EFC37368.1 77 KLKVLYCGNNKI 88
                7*********97 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.067
       LRR_1   2 LrhLdLsnnpll 13 
                 L+++ L++npl+
  EFC37368.1 103 LEEILLTGNPLE 114
                 89999*****94 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.36   1.3e+03       6      16 ..      12      22 ..      12      27 .. 0.79
   2 ?    5.0   0.0    0.0082        29       4      15 ..      32      43 ..      30      44 .. 0.91
   3 ?    4.5   0.1     0.013        45       3      16 ..      54      67 ..      52      76 .. 0.85
   4 ?   -2.1   0.0       1.6   5.8e+03       3       9 ..     133     139 ..     132     139 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.36
       LRR_6  6 teLdLsgNdIg 16
                + L Ls N+I+
  EFC37368.1 12 KRLALSTNCID 22
                5799999**97 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0082
       LRR_6  4 hLteLdLsgNdI 15
                +L+ L+L+ N+I
  EFC37368.1 32 SLEILSLARNQI 43
                79*********9 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.013
       LRR_6  3 thLteLdLsgNdIg 16
                ++L+ L Ls+N+++
  EFC37368.1 54 PTLEQLWLSYNNLT 67
                7999999*****98 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 1.6
       LRR_6   3 thLteLd 9  
                 ++L++Ld
  EFC37368.1 133 PSLKKLD 139
                 689*998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       450  (0.025099); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 983.14
//
Query:       EFC37369.1  [L=778]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-53  181.7   0.1    5.5e-53  180.0   0.0    1.9  2  Pkinase          Protein kinase domain
    2.6e-50  171.1   0.2    3.5e-49  167.4   0.2    2.1  1  Pkinase_Tyr      Protein tyrosine kinase
    5.6e-07   29.7  22.2      0.011   16.2   1.7    6.3  6  Chlam_PMP        Chlamydia polymorphic membrane protein (Chla
     0.0014   17.7   1.4     0.0018   17.3   0.0    2.0  2  Haspin_kinase    Haspin like kinase domain
  ------ inclusion threshold ------
      0.031   14.2   0.0      0.052   13.5   0.0    1.3  1  APH              Phosphotransferase enzyme family
      0.098   11.8   0.0       0.46    9.6   0.0    1.9  2  Fructosamin_kin  Fructosamine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0      0.86   2.6e+03      53      88 ..     313     349 ..     300     356 .. 0.78
   2 !  180.0   0.0   1.8e-56   5.5e-53       2     260 ..     472     768 ..     471     770 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.86
                 HHHS.CTTB--EEEEEEESSEEEEEEE--TTEBHHHH CS
     Pkinase  53 kklk.hpnivrlyevfeekdelylvleyveggeladl 88 
                  +++  + i+ + e   +++ + l +e++eg++ +++
  EFC37369.1 313 SSINsKSSIIIMHEKEANNTIMNLSFEWCEGESNFNI 349
                 55555677888888888899999999*9999986665 PP

  == domain 2  score: 180.0 bits;  conditional E-value: 1.8e-56
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS-- CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsls 96 
                 e  +++GeGs G+Vy a   ++g  vAvK +k++++  ++e  + +E ++l++l+hp ivrl+++  +++++y+v+ey+e+g+l++++      +++l+
  EFC37369.1 472 EISKRIGEGSHGSVYLAQ--WNGINVAVKSLKTDDELLEDE--FEHEASLLNSLRHPAIVRLFGISISSNTRYMVVEYLENGSLETAIAnsksGRKKLN 566
                 56799************9..9************99888665..*********************************************97766556788 PP

                 HHHHHHHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHH CS
     Pkinase  97 eeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl.keneyskkvDvWslGvilye 189
                  +e  +i++ + +g++ylHs +   +iHrDlK  N+L+d + + Ki+DFGl+k  ++s +  +t   gt  Y+APE++ +++e++++ Dv+s+ +i+ye
  EFC37369.1 567 LKEKIEILSGVSKGMDYLHSLKplsLIHRDLKCGNVLLDANLKPKICDFGLSKLTSNSGSfsMTMNLGTILYMAPELIgSGQEIGNALDVYSYSIIMYE 665
                 88999***************98888*********************************9999****************888999*************** PP

                 HHHSS-STTTSSHH.HHHHHHHHT....HHHHHHHCT..SHH...HHHTTS.........................-HHHHHHHHHHT-SSGCCSTTHH CS
     Pkinase 190 lltgkppfsgekgk.ekvekeldq....lekilkilg..etkeklpeasei.........................seeakdllkkllkkdpkkRltae 256
                 l++++ pf +++ k +k+++  +q    l   +++++    k  +++++e+                          ++  +l+k++++  p+kR++++
  EFC37369.1 666 LFFEEKPFFSNSPKiHKFSQSPHQdslaLSVPVMVVRgeRPKIPWNNNEELevwlrefiepfekknsldhetvcnvCSDYVELMKQCWNSIPSKRPSFR 764
                 ***99999843333133444444444333333333334433444445555599***********************9999******************* PP

                 HHHT CS
     Pkinase 257 ellq 260
                 e+ q
  EFC37369.1 765 EITQ 768
                 9987 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  167.4   0.2   1.2e-52   3.5e-49       1     259 []     471     770 ..     471     770 .. 0.90

  Alignments for each domain:
  == domain 1  score: 167.4 bits;  conditional E-value: 1.2e-52
                  EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..C CS
  Pkinase_Tyr   1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..e 96 
                  +e++k++GeG+ G+V+ ++++       ++VavK+lk + +   ++e+ +ea+++++l+hp iv+l g+ +++++ ++v+ey+++G+L++ + ++   
   EFC37369.1 471 IEISKRIGEGSHGSVYLAQWN------GINVAVKSLKTDDELL-EDEFEHEASLLNSLRHPAIVRLFGISISSNTRYMVVEYLENGSLETAIANSksG 561
                  57899****************......9********7665555.89**********************************************988446 PP

                  TTTSBHHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.EEHHHHHHH CS
  Pkinase_Tyr  97 kekltlkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.ftsksDvWs 190
                  ++kl+lk+++++   v+kGm+yL+s k   l+Hrdl + NvLl+ n + ki+DfGL++ + +++   + + +   + +mapE + +++ +  + Dv+s
   EFC37369.1 562 RKKLNLKEKIEILSGVSKGMDYLHSLKplsLIHRDLKCGNVLLDANLKPKICDFGLSKLT-SNSGSFSMTMNLGTILYMAPELIGSGQeIGNALDVYS 658
                  799*********************9876779***************************99.66666777888999*********887659999***** PP

                  HHHHHHHHHTTSSGT..........................................TTTSHHHHHHHHHHTTEES-BBTTS..BHHHHHHHHHHT-S CS
  Pkinase_Tyr 191 fGvllwEiftlgesp..........................................ypglkneevleklkegkrlekpekc..peelyelmkkcwee 244
                  ++++++E+f   e+p                                            ++  +e++e +++++ l++ + c  +++  elmk+cw++
   EFC37369.1 659 YSIIMYELFF-EEKPffsnspkihkfsqsphqdslalsvpvmvvrgerpkipwnnneELEVWLREFIEPFEKKNSLDHETVCnvCSDYVELMKQCWNS 755
                  *********9.6778899999**************************99988777555555667799***9999998888662268999********* PP

                  SGGGS--HHHHHHHH CS
  Pkinase_Tyr 245 dpeeRptfselvekl 259
                   p++Rp+f+e+++ l
   EFC37369.1 756 IPSKRPSFREITQYL 770
                  ***********9865 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.2      0.53   1.6e+03       2       9 ..      31      38 ..      30      42 .. 0.87
   2 !    6.0   0.0    0.0064        19       1      26 [.     102     117 ..     102     119 .. 0.92
   3 !   16.2   1.7   3.7e-06     0.011       1      28 []     127     144 ..     127     144 .. 0.93
   4 !   10.3   0.5   0.00028      0.84       4      27 ..     155     181 ..     154     182 .. 0.90
   5 !    7.3   0.6    0.0025       7.4       4      28 .]     193     207 ..     190     207 .. 0.91
   6 ?   -1.5   0.0       1.6   4.7e+03       1       9 [.     531     539 ..     531     551 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.53
   Chlam_PMP  2 itFsnNta 9 
                i+ snN++
  EFC37369.1 31 ISLSNNSS 38
                899****9 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0064
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAIy 26 
                 ++tF +N +          ++GGA+y
  EFC37369.1 102 ECTFRDNWS----------NQGGALY 117
                 689******..........******9 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 3.7e-06
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAIyae 28 
                 +++F nN+a          ++GGAIy+e
  EFC37369.1 127 NCLFINNKA----------SNGGAIYSE 144
                 689******..........*******96 PP

  == domain 4  score: 10.3 bits;  conditional E-value: 0.00028
   Chlam_PMP   4 FsnNtatvss...tptpaaggGGAIya 27 
                 F +N+a  ++       ++g+GGAIy+
  EFC37369.1 155 FISNQAIGNFegcLSVKDCGNGGAIYS 181
                 788999999999999999********8 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.0025
   Chlam_PMP   4 FsnNtatvsstptpaaggGGAIyae 28 
                 F++N a          ++GGA y+e
  EFC37369.1 193 FEYNLA----------VKGGACYGE 207
                 99****..........*******97 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 1.6
   Chlam_PMP   1 sitFsnNta 9  
                 +i++s+Nt 
  EFC37369.1 531 GISISSNTR 539
                 599****97 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.6       1.3     4e+03      59     104 ..     261     310 ..     253     335 .. 0.51
   2 !   17.3   0.0   6.1e-07    0.0018     226     262 ..     590     626 ..     445     634 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 1.3
  Haspin_kinase  59 kklrnsesllslnsqeev...kdfdevilsqilelc.kikkilneadlas 104
                     k +ns+s++s +s++ +   +   + i  +i+++  + ++ l + +  +
     EFC37369.1 261 WKTSNSKSIYSSTSNTIPklsLYPGQQITLEIIQIIdEFNNTLTSLQALP 310
                    46667777777666655544222234444444444433444444444433 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 6.1e-07
  Haspin_kinase 226 feFEHRdLhldniLvdknlnvtlidlklsRlessegk 262
                    + + HRdL+ +n+L+d+nl+  ++d+ ls+l+s++g 
     EFC37369.1 590 LSLIHRDLKCGNVLLDANLKPKICDFGLSKLTSNSGS 626
                    5677***************************977665 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   1.7e-05     0.052     158     196 ..     582     618 ..     544     621 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.7e-05
                 HH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 158 allpgelptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                 + l++  p +l+H+Dl+ gN+l+d++  +   + Df+++
  EFC37369.1 582 DYLHSLKPLSLIHRDLKCGNVLLDANLKPK--ICDFGLS 618
                 445556779***************555554..7777765 PP

>> Fructosamin_kin  Fructosamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00015      0.46      24      98 ..     476     551 ..     454     567 .. 0.72
   2 ?   -0.8   0.0      0.24   7.2e+02     184     212 ..     585     614 ..     559     615 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00015
  Fructosamin_kin  24 kveggeineayllseeeqrfFv...klnekealemFeaEaesLealaetqtirvPkvlavGelkdasfLvleyLelk.l 98 
                      +++ g+  + yl + +  ++ v   k++++  ++ Fe+Ea  L+ l++   +   +++ ++ ++++ ++v+eyLe + l
       EFC37369.1 476 RIGEGSHGSVYLAQWNGINVAVkslKTDDELLEDEFEHEASLLNSLRHPAIV---RLFGISISSNTRYMVVEYLENGsL 551
                      5555555555555555555554111677788999************666555...67999999************9833 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.24
  Fructosamin_kin 184 hqpkp.sllHGdLWsgNaaltkdgepvifd 212
                      h+ kp sl+H dL  gN+ l+++ +p i+d
       EFC37369.1 585 HSLKPlSLIHRDLKCGNVLLDANLKPKICD 614
                      4445549***********999997787776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (778 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.81u 0.37s 00:00:01.18 Elapsed: 00:00:00.54
# Mc/sec: 4298.82
//
Query:       EFC37370.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-06   27.0   2.8    4.3e-06   27.0   2.8    1.6  2  DUF2871   Protein of unknown function (DUF2871)
  ------ inclusion threshold ------
       0.17   10.7   1.1       0.31    9.9   1.1    1.3  1  MscS_TM   Mechanosensitive ion channel inner membrane domain 


Domain annotation for each model (and alignments):
>> DUF2871  Protein of unknown function (DUF2871)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   2.8   4.8e-10   4.3e-06       9      91 ..     125     218 ..     117     234 .. 0.73
   2 ?   -3.3   0.7       1.1     1e+04     115     128 ..     270     283 ..     259     289 .. 0.61

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 4.8e-10
     DUF2871   9 lvylilgllsGvfyReftklne.ftgk.....tqLsvvHtHllvLGfvvfL.lvllleklfklseek....kfkkffivYniglvltvvmmlvr 91 
                  ++++ ++ sG+ +Re+tk +  f++       q s++H H++ LG++v L lv+ll  ++ +++ek     f+  fi+Y+ig vl +++++++
  EFC37370.1 125 GIMILCAISSGFVFRELTKNSVpFSKVgdyayQQGSLIHGHFFSLGVFVPLtLVVLLFLSYVMTGEKvssgMFHVGFIIYEIGAVLALAAFCYK 218
                 4556678999*********76424433556668899************988344455556666655522225777799*******999988776 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.1
     DUF2871 115 igHilltvglvlll 128
                 i+H ++ +gl   +
  EFC37370.1 270 ISHGFMLIGLFKCV 283
                 55656666555444 PP

>> MscS_TM  Mechanosensitive ion channel inner membrane domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   1.1   3.4e-05      0.31     159     222 ..     126     189 ..     108     204 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 3.4e-05
     MscS_TM 159 aflllllllavflarllrpalglyankkeeeknslrlrrllylllvlaPlalavlaalGYyyTa 222
                 +++l+ +   ++++ l ++++++ +     ++++ +++  ++ l v++Pl+l+vl +l Y++T 
  EFC37370.1 126 IMILCAISSGFVFRELTKNSVPFSKVGDYAYQQGSLIHGHFFSLGVFVPLTLVVLLFLSYVMTG 189
                 34555555556666677778888777776777777**************************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1177  (0.0656478); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.36s 00:00:00.96 Elapsed: 00:00:00.55
# Mc/sec: 1610.41
//
Query:       EFC37371.1  [L=784]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-37  125.9   0.0      8e-06   25.6   0.0   10.5 10  NHL              NHL repeat
  ------ inclusion threshold ------
      0.023   15.1   9.4      0.056   13.8   9.4    1.7  1  EGF_2            EGF-like domain
      0.028   14.3   2.1        6.1    6.8   0.1    3.3  3  FlgD_ig          FlgD Ig-like domain
       0.05   13.5   0.0         36    4.2   0.0    4.3  4  Phytase-like     Esterase-like activity of phytase
       0.11   12.6   0.2        6.4    6.9   0.0    3.1  3  DUF5074          Domain of unknown function (DUF5074)
        1.8    8.5   5.5         54    3.7   0.1    4.3  5  Arg_repressor_C  Arginine repressor, C-terminal domain
        3.6    8.4   7.0         10    6.9   7.0    1.9  1  hEGF             Human growth factor-like EGF


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1     0.069   1.8e+02       3      19 ..      98     115 ..      98     119 .. 0.91
   2 !   25.6   0.0   3.1e-09     8e-06       1      26 [.     154     179 ..     154     181 .. 0.90
   3 !   22.2   0.0   3.8e-08   9.7e-05       1      26 [.     210     235 ..     210     237 .. 0.91
   4 !    5.1   0.0    0.0097        25      11      26 ..     278     293 ..     268     295 .. 0.88
   5 !    7.8   0.0    0.0014       3.6       3      22 ..     329     348 ..     327     353 .. 0.90
   6 !   10.4   0.0   0.00021      0.55       1      20 [.     444     464 ..     444     469 .. 0.90
   7 !    7.6   0.0    0.0017       4.2       3      25 ..     487     509 ..     485     512 .. 0.79
   8 !   21.6   0.0   5.8e-08   0.00015       1      27 [.     541     567 ..     541     568 .. 0.93
   9 !    6.1   0.0    0.0049        13       3      22 ..     599     618 ..     598     620 .. 0.90
  10 ?    1.8   0.0      0.11   2.8e+02       1      18 [.     650     667 ..     650     667 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.069
                 SEEEEEEE.TTTEEEEEE CS
         NHL   3 yPhGvavd.snGdiyVaD 19 
                 +P Gva+  +++d++++D
  EFC37371.1  98 QPGGVALYpNSNDLLISD 115
                 699*************99 PP

  == domain 2  score: 25.6 bits;  conditional E-value: 3.1e-09
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n P+Gvav snG++y+aD  nh ++
  EFC37371.1 154 LNTPTGVAVASNGEVYIADKSNHVIR 179
                 789*******************9665 PP

  == domain 3  score: 22.2 bits;  conditional E-value: 3.8e-08
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P G++++s+G++y+aDs+nh ++
  EFC37371.1 210 LNSPIGLSISSTGELYIADSKNHVIR 235
                 799********************665 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0097
                 TTTEEEEEECCCTEEE CS
         NHL  11 snGdiyVaDsenhrvq 26 
                 s+G++y+aD+ n+ ++
  EFC37371.1 278 STGEVYIADTLNSLIR 293
                 78*******9999887 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.0014
                 SEEEEEEETTTEEEEEECCC CS
         NHL   3 yPhGvavdsnGdiyVaDsen 22 
                  P++va++s G+ ++aD++n
  EFC37371.1 329 APTSVALSSLGEMFIADNGN 348
                 59*****************9 PP

  == domain 6  score: 10.4 bits;  conditional E-value: 0.00021
                 BSSEEEEEEETTTEEEEEE.C CS
         NHL   1 fnyPhGvavdsnGdiyVaD.s 20 
                 fn+P+ +a ++nGdi++aD +
  EFC37371.1 444 FNEPTRIACSKNGDIFIADlF 464
                 99*****************64 PP

  == domain 7  score: 7.6 bits;  conditional E-value: 0.0017
                 SEEEEEEETTTEEEEEECCCTEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrv 25 
                 +P+ v ++ +G+++VaD+ +h +
  EFC37371.1 487 SPQAVILTESGELLVADRSSHVI 509
                 577777789********999966 PP

  == domain 8  score: 21.6 bits;  conditional E-value: 5.8e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f+ P+++a+ +nGd+y+aD+ n  +++
  EFC37371.1 541 FSGPQDIALAPNGDLYIADYDNYLIRK 567
                 899*******************99876 PP

  == domain 9  score: 6.1 bits;  conditional E-value: 0.0049
                 SEEEEEEETTTEEEEEECCC CS
         NHL   3 yPhGvavdsnGdiyVaDsen 22 
                 yP++vav++ G+++ +D +n
  EFC37371.1 599 YPSSVAVSKEGEVFFSDGNN 618
                 8************9999887 PP

  == domain 10  score: 1.8 bits;  conditional E-value: 0.11
                 BSSEEEEEEETTTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVa 18 
                 f +++G++ ++ Gd++V+
  EFC37371.1 650 FMSATGLSFTPKGDLLVS 667
                 67789***********95 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   9.4   2.2e-05     0.056       7      32 .]     709     733 ..     705     733 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.2e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +C+g+G C +  + C+C+sg+ G  C
  EFC37371.1 709 ACSGNGNCTS-INTCSCKSGFGGERC 733
                 7*******84.559**********99 PP

>> FlgD_ig  FlgD Ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.1    0.0024       6.1      22      43 ..     163     184 ..     155     197 .. 0.91
   2 ?    5.4   0.1    0.0066        17      22      44 ..     219     241 ..     195     264 .. 0.74
   3 ?   -3.7   0.0       4.4   1.1e+04      24      41 ..     496     513 ..     494     515 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0024
                 SEEEEEEEE-SS--EEEEEEEE CS
     FlgD_ig  22 adevtvtikDasGevVrtidlg 43 
                 a++++v i D+s++v+r+i+l 
  EFC37371.1 163 ASNGEVYIADKSNHVIRKISLN 184
                 899****************985 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0066
                 SEEEEEEEE-SS--EEEEEEEEE CS
     FlgD_ig  22 adevtvtikDasGevVrtidlga 44 
                 ++++++ i D++++v+r+id+  
  EFC37371.1 219 SSTGELYIADSKNHVIRKIDANG 241
                 56789**************9864 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 4.4
                 EEEEEEE-SS--EEEEEE CS
     FlgD_ig  24 evtvtikDasGevVrtid 41 
                 ++++ + D s +v+r+i+
  EFC37371.1 496 SGELLVADRSSHVIRKIS 513
                 6788999***9**99986 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.014        36      72     100 ..     159     187 ..     151     194 .. 0.94
   2 ?    1.7   0.0     0.077     2e+02      72      99 ..     215     242 ..     201     247 .. 0.91
   3 ?   -0.2   0.0      0.31   7.8e+02      72     101 ..     332     361 ..     330     379 .. 0.83
   4 ?   -1.0   0.0      0.52   1.3e+03      72     101 ..     546     575 ..     531     584 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.014
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkl 100
                   g+ava++g++++++  ++ i++++++G++
    EFC37371.1 159 GVAVASNGEVYIADKSNHVIRKISLNGNI 187
                   7999***********************97 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.077
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGk 99 
                   g+ ++++g++++++  ++ i+++da+G 
    EFC37371.1 215 GLSISSTGELYIADSKNHVIRKIDANGI 242
                   788899********************95 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.31
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkll 101
                   ++a+++ g++++++ g+ +i+++d +G+ +
    EFC37371.1 332 SVALSSLGEMFIADNGNLYIRKVDTKGNSI 361
                   567788899*****************9864 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.52
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkll 101
                   +ia+ap+g++++++  +  i++ +++G+++
    EFC37371.1 546 DIALAPNGDLYIADYDNYLIRKLSKNGNIT 575
                   689999999999998888889999999875 PP

>> DUF5074  Domain of unknown function (DUF5074)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.0    0.0025       6.4      35      64 ..      46      75 ..      22      91 .. 0.81
   2 ?   -3.1   0.0         3   7.8e+03       5      24 ..     220     241 ..     218     245 .. 0.72
   3 ?    1.8   0.0      0.09   2.3e+02       1      29 [.     603     631 ..     603     655 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0025
     DUF5074 35 lsiesswyawtptslcasttenaLYfiggs 64
                 +i+ss    +p+ + +s+++n+LY+++ s
  EFC37371.1 46 SNIPSSFVFSRPNMFAISASSNILYMTEDS 75
                6788899999****************9987 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3
     DUF5074   5 kDGnvWaa..sgtkLvkinpkt 24 
                   G++++a  +++ + ki+++ 
  EFC37371.1 220 STGELYIAdsKNHVIRKIDANG 241
                 6799999975555677888875 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.09
     DUF5074   1 vvqskDGnvWaasgtkLvkinpktlevkt 29 
                 v+ sk+G+v+ + g+++ ki +k + v+ 
  EFC37371.1 603 VAVSKEGEVFFSDGNNIRKITSKGILVTI 631
                 5789****************998876665 PP

>> Arg_repressor_C  Arginine repressor, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.82   2.1e+03      30      46 ..     177     193 ..     174     194 .. 0.85
   2 ?    3.7   0.1     0.021        54      30      49 ..     233     252 ..     226     265 .. 0.86
   3 ?    2.9   0.0     0.038        98      24      45 ..     285     306 ..     283     307 .. 0.91
   4 ?    0.1   0.1      0.28   7.2e+02      16      45 ..     491     523 ..     488     524 .. 0.83
   5 ?   -3.3   0.0       3.4   8.8e+03      30      46 ..     564     580 ..     562     582 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.82
                      HHHH-..TTEEEEEE-S CS
  Arg_repressor_C  30 aiDslelpeilGtiAGd 46 
                      +i +++l++ ++tiAG+
       EFC37371.1 177 VIRKISLNGNISTIAGN 193
                      57788999999****96 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.021
                      HHHH-..TTEEEEEE-SSEE CS
  Arg_repressor_C  30 aiDslelpeilGtiAGdDTi 49 
                      +i +++ ++i++t AG+ Ti
       EFC37371.1 233 VIRKIDANGIISTFAGNGTI 252
                      68889999***********9 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.038
                      HHHHHHHHHH-..TTEEEEEE- CS
  Arg_repressor_C  24 AqavAaaiDslelpeilGtiAG 45 
                      A+ + ++i +++ ++i++t+AG
       EFC37371.1 285 ADTLNSLIRKVSKSGIISTVAG 306
                      7778899**************9 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.28
                      EEE-STTH...HHHHHHHHHH-..TTEEEEEE- CS
  Arg_repressor_C  16 vikTlpGa...AqavAaaiDslelpeilGtiAG 45 
                      vi T +G    A+    +i +++ ++++++iAG
       EFC37371.1 491 VILTESGEllvADRSSHVIRKISTNGVMSIIAG 523
                      77777777777888889999************9 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 3.4
                      HHHH-..TTEEEEEE-S CS
  Arg_repressor_C  30 aiDslelpeilGtiAGd 46 
                      +i +l+ ++ + t+AG+
       EFC37371.1 564 LIRKLSKNGNITTVAGN 580
                      67778888889999996 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   7.0    0.0039        10       1      22 []     710     728 ..     710     728 .. 0.94

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0039
                 --TT-EES..-SS..-EE--TTX CS
        hEGF   1 CnngGtCidgvgg.ykCiCpPGy 22 
                 C+++G C+    + ++C C++G+
  EFC37371.1 710 CSGNGNCT----SiNTCSCKSGF 728
                 ********....8889******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (784 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       546  (0.0304535); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.55
# Mc/sec: 4272.82
//
Query:       EFC37372.1  [L=335]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-25   89.1   0.6    9.9e-06   26.2   0.0    6.1  6  WD40           WD domain, G-beta repeat
    1.8e-14   53.8   0.0    0.00019   21.7   0.0    4.6  4  ANAPC4_WD40    Anaphase-promoting complex subunit 4 WD40 doma
     0.0013   17.8   0.8      0.053   12.5   0.0    3.1  4  Ge1_WD40       WD40 region of Ge1, enhancer of mRNA-decapping
  ------ inclusion threshold ------
      0.019   14.9   0.0      0.081   12.9   0.0    2.1  2  PQQ            PQQ enzyme repeat
      0.053   13.1   0.1         10    5.6   0.0    2.5  2  PQQ_2          PQQ-like domain
      0.067   12.2   0.0       0.14   11.1   0.0    1.5  2  Coatomer_WDAD  Coatomer WD associated region
       0.07   12.4   0.0       0.35   10.1   0.0    2.1  2  RAB3GAP2_N     Rab3 GTPase-activating protein regulatory subu


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   5.2e-06     0.013       8      37 ..       9      39 ..       4      39 .. 0.92
   2 !   14.8   0.1   1.6e-05      0.04       1      38 []      44      81 ..      44      81 .. 0.87
   3 !   11.8   0.0   0.00014      0.36      12      36 ..     150     175 ..     142     177 .. 0.85
   4 !   11.8   0.0   0.00014      0.35       2      37 ..     182     218 ..     181     219 .. 0.87
   5 ?   -0.1   0.0      0.77     2e+03       3      25 ..     225     247 ..     223     257 .. 0.74
   6 !   26.2   0.0   3.9e-09   9.9e-06       2      37 ..     279     315 ..     278     316 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 5.2e-06
                ESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  8 tGH.ssvtslafspdgawlasGsdDgtvriW 37
                  H ++++ l++s++g++l+++s+D++v +W
  EFC37372.1  9 HVHlKPISWLKYSREGDLLFASSKDQSVSVW 39
                569999************************* PP

  == domain 2  score: 14.8 bits;  conditional E-value: 1.6e-05
                TEEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  1 gqclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38
                gq+l+t++ H + v++++++   + l+++s D +v +Wd
  EFC37372.1 44 GQLLGTFK-HsGAVNCIDVNAACTRLLCASADMKVTLWD 81
                68999998.8455****98888888999999*******9 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 0.00014
                 S.EEEEEEETTSSEEEEEETTSEEEE CS
        WD40  12 s.vtslafspdgawlasGsdDgtvri 36 
                 + +ts a+ p ++ +++G dDgt+r 
  EFC37372.1 150 DkITSAAWGPLNKTIICGFDDGTIRT 175
                 349***************99****95 PP

  == domain 4  score: 11.8 bits;  conditional E-value: 0.00014
                 EEEEEEESSSS.EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   2 qclrtltGHss.vtslafspdgawlasGsdDgtvriW 37 
                 ++l++ + H++ v  l+fs+d  +++s+s D+t +++
  EFC37372.1 182 KQLGSTREHTHtVVRLSFSKDRMLFMSASTDKTAKLF 218
                 67888899955699**************99***9986 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 0.77
                 EEEEEESS.SSEEEEEEETTSSEE CS
        WD40   3 clrtltGH.ssvtslafspdgawl 25 
                 +l++++ H ++v+  a sp ++ +
  EFC37372.1 225 LLKVYK-HsDPVNTAAISPIKRHV 247
                 678887.8566*999888877765 PP

  == domain 6  score: 26.2 bits;  conditional E-value: 3.9e-09
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 + ++t +GH ++++ lafspdg+  asG++Dg vr++
  EFC37372.1 279 EEIGTVRGHfGPIHFLAFSPDGKSYASGGEDGYVRLY 315
                 568899***888***********************98 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.0   4.6e-05      0.12       1      84 [.      18      99 ..      18     107 .. 0.87
   2 !   21.7   0.0   7.2e-08   0.00019      35      89 ..     146     199 ..     124     201 .. 0.88
   3 !    6.1   0.0    0.0052        13      35      80 ..     188     233 ..     185     243 .. 0.87
   4 !   10.4   0.0   0.00024      0.61      37      68 ..     287     318 ..     265     325 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.6e-05
  ANAPC4_WD40  1 lswcptmDLiAlatedgellvfRl.ngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekav 84
                 l+++ + DL+   ++d+++ v  + ngq + t+   k+++ v+++  +   + L  a +d +v l d+++g  + s++ ++ ++v
   EFC37372.1 18 LKYSREGDLLFASSKDQSVSVWYThNGQLLGTF---KHSGAVNCIDVNAACTRLLCASADMKVTLWDVQTGAQLLSVDFATPTKV 99
                 589999*************99776477877777...999********************************99999988877554 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 7.2e-08
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                   +++ +++s aW p +k +  +++dg++r +daesgk + s + +++ +v+ l++
   EFC37372.1 146 IEQKDKITSAAWGPLNKTIICGFDDGTIRTFDAESGKQLGSTREHTH-TVVRLSF 199
                  57899**********************************99999888.4777766 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0052
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvks 80 
                   ++ ++v  L++++d  l++ a  d + +l+++++ ++++ ++ ++
   EFC37372.1 188 REHTHTVVRLSFSKDRMLFMSASTDKTAKLFESQTLELLKVYKHSD 233
                  5788999****************************99999887665 PP

  == domain 4  score: 10.4 bits;  conditional E-value: 0.00024
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldae 68 
                  + + ++ La++pdgk  a + +dg vrl++  
   EFC37372.1 287 HFGPIHFLAFSPDGKSYASGGEDGYVRLYQLD 318
                  5567899*********************9865 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.23   5.9e+02     230     284 ..      39      92 ..      26     119 .. 0.53
   2 ?    0.8   0.0     0.075   1.9e+02     183     215 ..     145     177 ..      67     183 .. 0.83
   3 ?    1.0   0.0     0.066   1.7e+02     171     215 ..     172     219 ..     161     232 .. 0.73
   4 !   12.5   0.0   2.1e-05     0.053     189     216 ..     290     317 ..     252     329 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.23
    Ge1_WD40 230 WkPhdGkslssllfldnhkeesdeqfWrfaitgadnnselklWscelWtClqtik 284
                 W  h+G+ l ++       ++ d++     + +a+++  + lW +++   l  + 
  EFC37372.1  39 WYTHNGQLLGTFKHSG-AVNCIDVNAACTRLLCASADMKVTLWDVQTGAQLLSVD 92 
                 5555555444433332.22333333333333444444555555555555555555 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.075
    Ge1_WD40 183 kieehsliveaafspdGtalatasedGevkffq 215
                 kie++ +i++aa+ p   ++     dG+++ f 
  EFC37372.1 145 KIEQKDKITSAAWGPLNKTIICGFDDGTIRTFD 177
                 789999999999999999999999999999885 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.066
    Ge1_WD40 171 elsveeieeg..llkieehs.liveaafspdGtalatasedGevkffq 215
                  +++ ++e+g  l   +eh+ ++v  +fs d      as+d + k+f 
  EFC37372.1 172 TIRTFDAESGkqLGSTREHThTVVRLSFSKDRMLFMSASTDKTAKLFE 219
                 55555555431133456666599******************9999986 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 2.1e-05
    Ge1_WD40 189 liveaafspdGtalatasedGevkffqv 216
                  i   afspdG + a   edG+v+++q+
  EFC37372.1 290 PIHFLAFSPDGKSYASGGEDGYVRLYQL 317
                 466679*********************7 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       5.7   1.5e+04      23      29 ..      79      85 ..      70      88 .. 0.63
   2 ?   12.9   0.0   3.2e-05     0.081       2      23 ..     163     184 ..     162     188 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 5.7
                EEEEESS CS
         PQQ 23 lWrfktg 29
                lW ++tg
  EFC37372.1 79 LWDVQTG 85
                5555555 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 3.2e-05
                 EEEEEETTSEEEEEETTTCCEE CS
         PQQ   2 vvylgsadGylyAlDadTGkvl 23 
                 ++++g +dG+++ +Da++Gk l
  EFC37372.1 163 TIICGFDDGTIRTFDAESGKQL 184
                 68999**************976 PP

>> PQQ_2  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1    0.0088        23      37      71 ..      66     100 ..      32     120 .. 0.64
   2 ?    5.6   0.0    0.0041        10      84     106 ..     169     191 ..     131     243 .. 0.64

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0088
       PQQ_2  37 gtlfvatgggrlvaldaatGkvlWettlegpvvga 71 
                  +l++a+   +++ +d  tG++l ++++  p++  
  EFC37372.1  66 TRLLCASADMKVTLWDVQTGAQLLSVDFATPTKVV 100
                 46666677777777777777777777776665444 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0041
       PQQ_2  84 sdgqlialdaedGkrlWstqqrs 106
                 +dg+++++dae+Gk+l st +++
  EFC37372.1 169 DDGTIRTFDAESGKQLGSTREHT 191
                 33333333333333333322222 PP

>> Coatomer_WDAD  Coatomer WD associated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   5.6e-05      0.14      84     188 ..      29     135 ..      15     159 .. 0.68
   2 ?   -2.8   0.0      0.96   2.5e+03     125     167 ..     170     214 ..     163     240 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.6e-05
                    XXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXX.XXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXX....XXXXXXX CS
  Coatomer_WDAD  84 vlessksvkifknfkekktksikleyqvdkifg....GalLgvksegsvsfYDweqgklvrridvkk.vknVvwsddgelvalvs....kdtvyil 170
                    +  + +sv++    +++   ++k++ +v+ i        lL+++ +  v+++D+++g ++ ++d     k V  s+  + +  v+    k+t  i 
     EFC37372.1  29 ASSKDQSVSVWYTHNGQLLGTFKHSGAVNCIDVnaacTRLLCASADMKVTLWDVQTGAQLLSVDFATpTKVVQFSEGDKQFLAVTdssfKQTPSIQ 124
                    445689999999999999999999999999988889999*************************77548999998876655555412224444444 PP

                    XXXXX............. CS
  Coatomer_WDAD 171 synleaveeedeeegved 188
                     ++l        eeg e+
     EFC37372.1 125 IFKLP-------EEGTES 135
                    44444.......444443 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.96
                    XX.XXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXX CS
  Coatomer_WDAD 125 egsvsfYDweqgklvrridvkk..vknVvwsddgelvalvskdtv 167
                    +g++  +D e+gk++ + + +   v +   s+d+ l++ +s d++
     EFC37372.1 170 DGTIRTFDAESGKQLGSTREHThtVVRLSFSKDRMLFMSASTDKT 214
                    556777888888887777655323666666777766666655554 PP

>> RAB3GAP2_N  Rab3 GTPase-activating protein regulatory subunit N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   0.00014      0.35      53     113 ..     148     199 ..     104     231 .. 0.77
   2 ?   -1.1   0.0      0.34   8.6e+02      74      98 ..     298     322 ..     293     326 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00014
  RAB3GAP2_N  53 eeeiItailclplsskssqgspdwtviavGlssGylrfyt.engelLlsqllheepvlkikc 113
                 ++ +It+  + pl++           i++G+++G +r ++ e+g+ L s   h+  v+++  
  EFC37372.1 148 QKDKITSAAWGPLNK----------TIICGFDDGTIRTFDaESGKQLGSTREHTHTVVRLSF 199
                 445578888877777..........9***********996489****************994 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.34
  RAB3GAP2_N  74 pdwtviavGlssGylrfytengelL 98 
                 pd + +a G ++Gy+r+y+ + + L
  EFC37372.1 298 PDGKSYASGGEDGYVRLYQLDRQYL 322
                 56667788999*******9887666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 1964.30
//
Query:       EFC37373.1  [L=432]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-26   93.3   0.2    6.6e-06   26.7   0.0    6.7  6  RCC1      Regulator of chromosome condensation (RCC1) repeat
    4.8e-18   64.5  11.7     0.0029   17.4   0.0    7.2  7  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0   0.00052       4.6      35      50 .]      48      66 ..      23      66 .. 0.78
   2 !   10.8   0.0   6.4e-05      0.57       3      50 .]      76     131 ..      74     131 .. 0.72
   3 !   10.5   0.0     8e-05      0.72       6      21 ..     158     173 ..     155     199 .. 0.77
   4 !    4.3   0.0     0.007        63       3      19 ..     209     225 ..     207     251 .. 0.86
   5 !   26.7   0.0   7.4e-10   6.6e-06       1      50 []     254     300 ..     254     300 .. 0.90
   6 !   24.3   0.0   3.9e-09   3.5e-05       2      49 ..     304     350 ..     304     351 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00052
                S...-EEEEEEETTEEEEE CS
        RCC1 35 n...rvvkvacGddhtval 50
                    +v++++cG+d+ ++l
  EFC37373.1 48 YskyKVISISCGGDFLFLL 66
                13459*********99875 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 6.4e-05
                 EEEEEE--GGGTTSSSS-..--EEE.....EEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt..esvlv.....Ptkveglsgn..rvvkvacGddhtval 50 
                 r++s G n  G  G +t+   s+ +     P  +e  +++  ++ ++ cG++h++ l
  EFC37373.1  76 RLFSAGYNGTGEQGVPTNsgSSCELrditdP-IIEHIKRKniKILQAQCGWNHSMIL 131
                 7888888888888887777633322333568.5666666679************975 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 8e-05
                 EEE--GGGTTSSSS-- CS
        RCC1   6 sWGrndyGqLGlgtte 21 
                 + G+n++GqLG g+  
  EFC37373.1 158 GSGFNNHGQLGVGNAS 173
                 569*********9873 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.007
                 EEEEEE--GGGTTSSSS CS
        RCC1   3 rVysWGrndyGqLGlgt 19 
                 ++y+ G+n+ G LG ++
  EFC37373.1 209 NLYAAGNNSSGELGKPN 225
                 69************766 PP

  == domain 5  score: 26.7 bits;  conditional E-value: 7.4e-10
                 TTEEEEEE--GGGTTSSSS-..--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt..esvlvPtkveglsgnrvvkvacGddhtval 50 
                 +G+V++ Grnd+G LG+ ++      v tkv +++  +++kv+ G +ht++l
  EFC37373.1 254 EGQVWTAGRNDNGKLGRSDSnlM---VFTKVDFPE--KAIKVSLGIHHTMVL 300
                 7****************998553...4489****9..*************97 PP

  == domain 6  score: 24.3 bits;  conditional E-value: 3.9e-09
                 TEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS.-EEEEEEETTEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesvlvPtkveglsgn.rvvkvacGddhtva 49 
                 G+Vy+ G n++G LG+ t++ +  P+     s+n ++++++cG ++t +
  EFC37373.1 304 GNVYGAGYNENGELGINTNQAS--PVFKLVESNNlKFKDISCGFYFTSF 350
                 99********************..84333333446********999976 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.0   0.00068       6.1       1      25 [.      53      82 ..      53      87 .. 0.72
   2 !    7.2   0.2    0.0005       4.5       3      16 ..     120     133 ..     118     166 .. 0.64
   3 !   11.0   0.0   3.2e-05      0.29       8      29 ..     197     219 ..     195     220 .. 0.91
   4 !   10.7   0.0     4e-05      0.36       8      29 ..     245     266 ..     241     267 .. 0.93
   5 !   17.4   0.0   3.2e-07    0.0029       2      29 ..     288     315 ..     287     316 .. 0.94
   6 !   12.8   0.0   8.4e-06     0.076       2      25 ..     339     362 ..     338     362 .. 0.95
   7 ?   -3.4   0.0         1   9.2e+03       3      10 ..     389     396 ..     387     399 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.00068
      RCC1_2  1 VksvsaGdyHscaLtedGe.....VlcWGs 25
                V+s+s+G+++ + L+ d       +++ G 
  EFC37373.1 53 VISISCGGDFLFLLLQDKVtlqnrLFSAGY 82
                89*******988887775555555555555 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0005
      RCC1_2   3 svsaGdyHscaLte 16 
                 +  +G++Hs++L+e
  EFC37373.1 120 QAQCGWNHSMILVE 133
                 667*********98 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 3.2e-05
      RCC1_2   8 dyHsca.LtedGeVlcWGsNsdG 29 
                 ++ +ca +t d ++++ G+Ns+G
  EFC37373.1 197 RFNTCAiITKDRNLYAAGNNSSG 219
                 5789999**************99 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 4e-05
      RCC1_2   8 dyHscaLtedGeVlcWGsNsdG 29 
                 ++Hs++++ +G V++ G+N++G
  EFC37373.1 245 YSHSVIIDMEGQVWTAGRNDNG 266
                 79*****************998 PP

  == domain 5  score: 17.4 bits;  conditional E-value: 3.2e-07
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 ++vs G  H+++Lte G+V++ G N++G
  EFC37373.1 288 IKVSLGIHHTMVLTELGNVYGAGYNENG 315
                 68999*********************99 PP

  == domain 6  score: 12.8 bits;  conditional E-value: 8.4e-06
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGs 25 
                 k++s+G y++ +Lt+++ V+ +Gs
  EFC37373.1 339 KDISCGFYFTSFLTRSNQVMICGS 362
                 89********************97 PP

  == domain 7  score: -3.4 bits;  conditional E-value: 1
      RCC1_2   3 svsaGdyH 10 
                 s+ aG+y+
  EFC37373.1 389 SIYAGGYF 396
                 8899*997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2714.58
//
Query:       EFC37374.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.9e-06   26.1   0.0    1.7e-05   24.8   0.0    1.7  2  AAA_5        AAA domain (dynein-related subfamily)
    0.00037   20.8   0.0    0.00068   19.9   0.0    1.3  1  AAA_22       AAA domain
     0.0016   18.6   0.0     0.0034   17.6   0.0    1.4  1  AAA_33       AAA domain
  ------ inclusion threshold ------
      0.047   13.2   0.0      0.083   12.4   0.0    1.4  1  AAA_7        P-loop containing dynein motor region
      0.057   12.6   0.4       0.12   11.5   0.4    1.6  1  NB-ARC       NB-ARC domain
      0.078   12.7   0.0       0.22   11.3   0.0    1.7  1  AAA_29       P-loop containing region of AAA domain
       0.13   12.1   0.0       0.22   11.4   0.0    1.5  1  RsgA_GTPase  RsgA GTPase
       0.18   11.5   0.0       0.25   11.0   0.0    1.2  1  AAA_30       AAA domain


Domain annotation for each model (and alignments):
>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       5.1   1.2e+04      79      95 ..     130     146 ..     126     148 .. 0.80
   2 !   24.8   0.0   7.7e-09   1.7e-05       6      60 ..     152     207 ..     150     236 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 5.1
                 HHHHHHHHHHHHSSEEE CS
       AAA_5  79 sevlnsLlslleerrll 95 
                 s+++++ l+l+++ +l+
  EFC37374.1 130 SNIFSKTLTLMHNCKLH 146
                 68889999999988887 PP

  == domain 2  score: 24.8 bits;  conditional E-value: 7.7e-09
                 --SSSSHHHHHHHGGGGB.S--EEEEE--TT--HHHHH--B--.........---- CS
       AAA_5   6 GppGtgKselaerlaaal.nreveyvqltrdtteedlkgrreikngttslvdsplv 60 
                 G++G+gK+++ e   ++l   ++  + l++ tt +++  ++++ +++ts++d +++
  EFC37374.1 152 GESGIGKTTMLEDSIRLLnPHPYMLISLSETTTIAEIAAQMNMLEKETSWSDIEFT 207
                 9*****************99********************************9887 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0     3e-07   0.00068      11     102 ..     151     234 ..     150     256 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 3e-07
      AAA_22  11 tGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdllrellralglelka.erlsseellealeqalraravielliiDEaqh 102
                 +GesG+GKTt l+   + l+        + +++++ l++ t+ ++++ ++    ++   +  + + + ++++  ++lr+ +  +l+iiD+a +
  EFC37374.1 151 HGESGIGKTTMLEDSIRLLN--------PHPYMLISLSETTTIAEIAAQMNMLEKETSWSdIEFTVKKYIDLHSKNLRSMHC-PLFIIDNANR 234
                 8******************6........89999************97777655444333368899999999999******99.*******987 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   1.5e-06    0.0034       4      94 ..     150     248 ..     149     252 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.5e-06
      AAA_33   4 lvGlpGsGKstlae...rllkklgavllssdt......lrrrlfgtdqqsktdytrvldrlyqilnelarkalsagrn.vildatnlsrrerarflkla 92 
                 ++G +G GK+t +e   rll+++++ l+s  +      +  ++   +  ++t ++++++ +++ +    +  +s  ++ +i+d+ n+++    rf++++
  EFC37374.1 150 FHGESGIGKTTMLEdsiRLLNPHPYMLISLSEtttiaeIAAQMNMLE--KETSWSDIEFTVKKYIDLHSKNLRSMHCPlFIIDNANRNAPIANRFISMV 246
                 89**********99333468888888877666555553333444444..4455678888999999555555557788899********99999999988 PP

      AAA_33  93 rr 94 
                 r+
  EFC37374.1 247 RE 248
                 85 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.7e-05     0.083      38      81 ..     150     191 ..     116     201 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.7e-05
       AAA_7  38 lvGptGtGKtviikdllkkldkekylsltinfsaqtsanqlqdi 81 
                 + G++G GKt++++d ++ l++  y+   i++s +t+ +++   
  EFC37374.1 150 FHGESGIGKTTMLEDSIRLLNPHPYML--ISLSETTTIAEIAAQ 191
                 89*******************777765..566666666665444 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.4   5.4e-05      0.12      13      70 ..     138     190 ..     128     230 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5.4e-05
                 HCTTTSCSEEEEEEESTTSSHHHHHHHHCCSHCCCCCCBTEEEEEEEESXXHHHHHHH CS
      NB-ARC  13 lekdelqslvvalvGmgGvGKttlakqilnksdevegrFdsvawvvvsktdkseeile 70 
                   +++ ++ + +++G  G+GKtt++++ ++    +  +   ++ +++s+t ++ ei  
  EFC37374.1 138 TLMHNCKLHMKGFHGESGIGKTTMLEDSIRL---L--NPHPYMLISLSETTTIAEIAA 190
                 44555555599************98765544...1..122345555555555555555 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   9.7e-05      0.22      15      49 ..     141     172 ..     135     176 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 9.7e-05
      AAA_29  15 htieidlkgatlltGpsGsGKSTllDAiqalLvpa 49 
                 h  ++++kg   + G+sG GK+T+l   + lL p+
  EFC37374.1 141 HNCKLHMKG---FHGESGIGKTTMLEDSIRLLNPH 172
                 667788888...99***********8888888886 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   9.6e-05      0.22      90     117 ..     136     163 ..      92     194 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 9.6e-05
                  HHHHHHHCTTSEEEEECSTTSSHHHHHH CS
  RsgA_GTPase  90 leelkellkdktsvlvGqSGvGKStLin 117
                  + +l +++k ++  + G+SG+GK+t+++
   EFC37374.1 136 TLTLMHNCKLHMKGFHGESGIGKTTMLE 163
                  55788889999999***********986 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00011      0.25      20      64 ..     147     191 ..     135     236 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00011
      AAA_30  20 vavltGpAGtGKttalkalreaweaaggrviglAptgkaAkvLae 64 
                 ++  +G  G GKtt+l+   ++++ + + +i l+ t + A+  a+
  EFC37374.1 147 MKGFHGESGIGKTTMLEDSIRLLNPHPYMLISLSETTTIAEIAAQ 191
                 66789******************************9999876553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       976  (0.0544369); expected 358.6 (0.02)
Passed bias filter:                      617  (0.0344135); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.42u 0.27s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1862.56
//
Query:       EFC37375.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.097   12.9   0.0       0.19   11.9   0.0    1.4  1  T2SSJ     Type II secretion system (T2SS), protein J


Domain annotation for each model (and alignments):
>> T2SSJ  Type II secretion system (T2SS), protein J
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0     1e-05      0.19      84     135 ..     346     397 ..     336     401 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1e-05
                 EEEEEESSEEEEEEEEE-TTSSEESSSS-SSS-HH.C--SEEEEEEEETTTEE CS
       T2SSJ  84 qeqvlLegveelelrfldqdnqwqeeWppeaaeaa.slPeaVeitlelkdlge 135
                  ++v  e++ el++++ ++  + q+e +p++++++ +lPe ++i ++l+++++
  EFC37375.1 346 NKTVPFENIAELSYNYQSNS-KFQQENKPDESKSKsTLPEEIQIDIKLNKWRK 397
                 567899*********99999.888887777777667*************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1443  (0.0804841); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 3736.31
//
Query:       EFC37376.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.076   12.6   0.0       0.65    9.6   0.0    2.0  2  CD34_antigen  CD34/Podocalyxin family


Domain annotation for each model (and alignments):
>> CD34_antigen  CD34/Podocalyxin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1     0.019   3.4e+02      78     126 ..      37      88 ..      11      94 .. 0.77
   2 ?    9.6   0.0   3.6e-05      0.65     112     150 ..     181     219 ..     177     231 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.019
  CD34_antigen  78 LeklgIqnl...tsvkeaqeedirseqdyskkllialvtsglllaiLlvagy 126
                   ++  gI n+    sv+e+ +e  + + +   + ++a v++++   ++++ag+
    EFC37376.1  37 FHFDGIGNVfftVSVEECLDETKTLRTSEIALPIVATVLGSVGGTAVVIAGL 88 
                   5555665542212578999999999999999999999*99999999999986 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 3.6e-05
  CD34_antigen 112 vtsglllaiLlvagyYgclhrRlskskagerLgEelqyv 150
                   +tsgl +a+ +vag++g++++  + + + er+g e +y 
    EFC37376.1 181 ITSGLTSAVSVVAGVFGKIKQIQPVNDQIERIGKEKKYS 219
                   89*******************************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       843  (0.0470188); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1428.00
//
Query:       EFC37377.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.5e-22   78.5   0.0    6.6e-22   78.0   0.0    1.3  1  Methyltransf_31  Methyltransferase domain
    1.5e-12   48.0   0.0    3.5e-12   46.9   0.0    1.6  1  Methyltransf_25  Methyltransferase domain
    1.2e-11   45.1   0.0    3.3e-11   43.7   0.0    1.8  2  Methyltransf_11  Methyltransferase domain
    1.7e-09   38.3   0.0    3.5e-09   37.3   0.0    1.5  1  Methyltransf_12  Methyltransferase domain
    4.5e-09   36.0   0.0    1.8e-07   30.8   0.0    2.2  2  Ubie_methyltran  ubiE/COQ5 methyltransferase family
    2.7e-08   33.8   0.0    3.8e-08   33.3   0.0    1.2  1  Methyltransf_23  Methyltransferase domain
    1.7e-05   24.4   0.1    0.00087   18.9   0.1    2.3  2  DOT1             Histone methylation protein DOT1
    0.00022   21.0   0.1    0.00037   20.3   0.1    1.3  1  PCMT             Protein-L-isoaspartate(D-aspartate) O-methyl
  ------ inclusion threshold ------
      0.017   15.1   0.0       0.03   14.3   0.0    1.4  1  Methyltransf_32  Methyltransferase domain
      0.044   13.8   0.0       0.14   12.1   0.0    1.8  1  ADH_zinc_N       Zinc-binding dehydrogenase
       0.14   12.6   0.1       0.45   11.0   0.0    1.8  1  HMA              Heavy-metal-associated domain
       0.32   11.7   1.8         11    6.8   0.2    2.8  3  DUF5502          Family of unknown function (DUF5502)


Domain annotation for each model (and alignments):
>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.0   0.0   4.4e-25   6.6e-22       3     125 ..      63     196 ..      62     244 .. 0.86

  Alignments for each domain:
  == domain 1  score: 78.0 bits;  conditional E-value: 4.4e-25
  Methyltransf_31   3 kglrvlDlGCGtGeltfelaeelgpkaevvGiDiseeaielAre.........naqklgldnveFeqgdieelekl..ledekfDlilsnevln 85 
                      kgl+vlDlG+G G+++f +   +g++++v+G+D+++  +e+Are         + ++ ++  +eF++g ieel++   ++ e++Dli+sn+v+n
       EFC37377.1  63 KGLTVLDLGSGIGRDVFLASIIVGEQGKVIGVDMTKSQVEQAREftpkfiesiKNANMNIAKIEFHEGLIEELDQIpgVTSESIDLITSNCVIN 156
                      689**************9999*****************************98866778888*************9877777************* PP

  Methyltransf_31  86 aladpdkileeiervlkpggilliedprllaelpakveee 125
                      + + ++++l+++ +vlk gg+++ +d+   ++    ++e+
       EFC37377.1 157 LSPKKEQVLRQVYKVLKFGGEFVFSDIYSDRKIHPAAREK 196
                      **************************99555555444444 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.9   0.0   2.3e-15   3.5e-12       1      97 []      67     176 ..      67     176 .. 0.82

  Alignments for each domain:
  == domain 1  score: 46.9 bits;  conditional E-value: 2.3e-15
                      EEEET-TTSHHHHHHHCTST.SSEEEEEESSHHHHHHHH..........HHHHHTTT...TEEEEESBCCGBS....SSTTTEEEEEEEST.GG CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrlg.kakvtgvDiseemleaar..........eraeeegl...nvefvqgdaedlp....fedgsfDlvvssga.lh 75 
                      vLdlG G Gr+++ ++  +g ++kv+gvD++++++e+ar          +   ++++   ++ef++g +e+l+      ++s+Dl++s ++ ++
       EFC37377.1  67 VLDLGSGIGRDVFLASIIVGeQGKVIGVDMTKSQVEQAReftpkfiesiK---NANMniaKIEFHEGLIEELDqipgVTSESIDLITS-NCvIN 156
                      9**********99988888669*****************77777774433...3344567*********999844455999*******.57355 PP

                      GSSHHHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  76 hlsdedlekalkeiarvLkpgG 97 
                       ls ++ e++l+++++vLk gG
       EFC37377.1 157 -LS-PKKEQVLRQVYKVLKFGG 176
                      .55.4669***********999 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.7   0.0   2.2e-14   3.3e-11       1      96 []      68     180 ..      68     180 .. 0.88
   2 ?   -2.4   0.0       5.1   7.6e+03       6      39 ..     205     237 ..     200     250 .. 0.62

  Alignments for each domain:
  == domain 1  score: 43.7 bits;  conditional E-value: 2.2e-14
                      EEET-TTSHHHHHHH....HTTSEEEEEES-HHHHHHHHHHCCHHT-..........EEEETTEECCCT.S...S-TT-EEEEEEES-CCC-CC CS
  Methyltransf_11   1 LdvGcGtGrlaeala....krgarvvgvDlskemlklakekaseegl..........kvefvvadaekl.p...fednsfDlvvssevlhhved 76 
                      Ld+G+G Gr +        ++ ++v+gvD++k ++++a+e +++  +          k+ef+++ +e+l +   + ++s+Dl++s+ v++  ++
       EFC37377.1  68 LDLGSGIGRDVFLASiivgEQ-GKVIGVDMTKSQVEQAREFTPKFIEsiknanmniaKIEFHEGLIEELdQipgVTSESIDLITSNCVINLSPK 160
                      89******9999988755444.5***************999988777888898999999999999997522336999***************** PP

                      HHHHHHHHHHHEEEEEEEEE CS
  Methyltransf_11  77 pekalkeiaRvLkpgGllvi 96 
                       e++l+++++vLk gG +v+
       EFC37377.1 161 KEQVLRQVYKVLKFGGEFVF 180
                      ****************9997 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 5.1
                      TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCC CS
  Methyltransf_11   6 GtGrlaealakrgarvvgvDlskemlklakekas 39 
                      Gt ++++++ ++ +r +g+D+  e  +l +e + 
       EFC37377.1 205 GTVYYVNDFLNT-CRKIGFDVIRENSELTEEDYG 237
                      444555555544.477888888777777666655 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.3   0.0   2.3e-12   3.5e-09       1      98 [.      68     177 ..      68     178 .. 0.80

  Alignments for each domain:
  == domain 1  score: 37.3 bits;  conditional E-value: 2.3e-12
  Methyltransf_12   1 LeiGcGtGsllrallekl...pdieytgvDispsaiedakeklakrenn.nnnnvelealdlldldgg............ssfDlvvasnvlhh 78 
                      L++G+G G+ ++  l+++   ++ +++gvD  +s++e+a+e + k ++  +n+n+++ +++ ++                +s Dl+++++v++ 
       EFC37377.1  68 LDLGSGIGRDVF--LASIivgEQGKVIGVDMTKSQVEQAREFTPKFIESiKNANMNIAKIEFHEG--LieeldqipgvtsESIDLITSNCVINL 157
                      899999998655..44555689**************99999887776531344444444444433..25699999******************* PP

  Methyltransf_12  79 lkdirevldnirklLkpgGr 98 
                       +++++vl++++k+Lk gG 
       EFC37377.1 158 SPKKEQVLRQVYKVLKFGGE 177
                      *****************996 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   0.0   1.2e-10   1.8e-07      46     151 ..      62     180 ..      42     192 .. 0.81
   2 ?    2.9   0.0     0.038        57     181     225 ..     273     318 ..     258     323 .. 0.87

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 1.2e-10
                      --TTEEEEES-TT-HHHHHHHHHHHHHHEEEEEES-HHHHHHHHH.......HHHHHTSS...TEEEEE--TTT-TTS-....T-EEEEEEES- CS
  Ubie_methyltran  46 krgakvlDvagGtgDlafklsdsvgekgkvvvlDinenmLkvgek.......klkeegki...nieflqanaeeLpfed....dsfDvvtvsfG 125
                       +g +vlD+ +G g   f  s  vge+gkv+++D+ ++ ++++++        +k+   +   +ief  +  eeL+       +s D++t    
       EFC37377.1  62 IKGLTVLDLGSGIGRDVFLASIIVGEQGKVIGVDMTKSQVEQAREftpkfieSIKNAN-MniaKIEFHEGLIEELDQIPgvtsESIDLITSNCV 154
                      6899**********999*99*********************99974442222223322.24679*********998753222389*****9999 PP

                      GGG-S-HHHHHHHHHHHEEEEEEEEE CS
  Ubie_methyltran 126 lrnvtDklkaLkeayrvlkpGGrlvv 151
                      +   + k+++L+++y+vlk GG++v 
       EFC37377.1 155 INLSPKKEQVLRQVYKVLKFGGEFVF 180
                      9999999***************9975 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.038
                      HHS-HHHHHHHHHHHHHS--HHHHH.HHHHHTTEEEEEEEEEGGGT CS
  Ubie_methyltran 181 lakdldsyryLvesirafPdqetlk.eliedaGfksveyesltgGv 225
                      +a  +++  +L +   +fP++ +++   ++++ + +ve +++t+ +
       EFC37377.1 273 VASAIEESAWLSNHFVQFPNKREFHyGEFKESSIGQVEVKQVTFQI 318
                      68889999***************97457999999999999999866 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.0   2.5e-11   3.8e-08      22     163 ..      63     225 ..      35     227 .. 0.71

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 2.5e-11
  Methyltransf_23  22 aggrvLdiGcGtGi...llevlrengfsvtgvDlspeaveiae...............kakkaqkdqfdeqeaae....pqgkfdlIvlrevle 93 
                      +g  vLd+G G G+   l++++  ++ +v+gvD+   +ve a+               ++ k +++    +e ++     ++++dlI+++ v++
       EFC37377.1  63 KGLTVLDLGSGIGRdvfLASIIVGEQGKVIGVDMTKSQVEQAReftpkfiesiknanmNIAKIEFHEGLIEELDQipgvTSESIDLITSNCVIN 156
                      5568*********86644666677788**************99998887766655444333333333333333334444555************ PP

  Methyltransf_23  94 hvpdppellrqiatllkpgGylllseplasl...kedrllldwlylvpagrhisffsarslkelleeaGlevv 163
                        p  + +lrq+++ lk gG +++s++ ++    +++r  l++l        + ++   ++ + +++ G++v+
       EFC37377.1 157 LSPKKEQVLRQVYKVLKFGGEFVFSDIYSDRkihPAAREKLSILGSC----IGTVYYVNDFLNTCRKIGFDVI 225
                      **************************866552222333333333222....2244444467777777777766 PP

>> DOT1  Histone methylation protein DOT1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.1   5.8e-07   0.00087      46     123 ..      67     145 ..      62     186 .. 0.78
   2 ?    3.0   0.0     0.042        63      48      86 ..     199     236 ..     177     244 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 5.8e-07
                 EEEES-TTSHHHHHHHHHH--S.EEEEEE--HHHHHHHHHHHHHHHHHHHHTTB----EEEESS-STT-HHHHHHGGG- CS
        DOT1  46 FvDLGSGvGnvvlqaalevgck.lsvGvEimdnaselaekqkeelkkrlklfGkklakiefirksFvenekveeiieea 123
                  +DLGSG+G+ v++a+  vg + + +Gv+++++  e a++ +  + + +k   ++ akief ++   e +++  + +e+
  EFC37377.1  67 VLDLGSGIGRDVFLASIIVGEQgKVIGVDMTKSQVEQAREFTPKFIESIKNANMNIAKIEFHEGLIEELDQIPGVTSES 145
                 68***************999873679***********************************998777777777776554 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.042
                 EES-TTSHHHHHHHHHH--SEEEEEE--HHHHHHHHHHH CS
        DOT1  48 DLGSGvGnvvlqaalevgcklsvGvEimdnaselaekqk 86 
                  LGS +G v         c+  +G ++  + sel+e+ +
  EFC37377.1 199 ILGSCIGTVYYVNDFLNTCR-KIGFDVIRENSELTEEDY 236
                 59*****9888777777777.9*************9876 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.1   2.5e-07   0.00037      73     116 ..      63     106 ..      60     130 .. 0.90

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 2.5e-07
                 TT-EEEEES-TTSHHHHHHHHHHCTTCEEEEEESBHHHHHHHHH CS
        PCMT  73 kgarvLevGsGsGyltavlarlvgekgrvvsierikelveeakr 116
                 kg  vL++GsG G    + + +vge+g+v++++ +k+ ve+a++
  EFC37377.1  63 KGLTVLDLGSGIGRDVFLASIIVGEQGKVIGVDMTKSQVEQARE 106
                 5789************************************9986 PP

>> Methyltransf_32  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0     2e-05      0.03      27      90 ..      65     123 ..      57     172 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2e-05
  Methyltransf_32  27 ltvvDvGaGkg...YLsfvlalkekeyklkvvgidakeelvekaekraeklgkkfnkrlsfaelsie 90 
                      ltv+D+G+G g   +L++++       + kv+g+d+ ++ ve+a++   k+ + +    + a+++i+
       EFC37377.1  65 LTVLDLGSGIGrdvFLASIIVG----EQGKVIGVDMTKSQVEQAREFTPKFIESI----KNANMNIA 123
                      699******9955567777777....599*****************999987444....33333333 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   9.5e-05      0.14      16     116 ..      90     206 ..      74     220 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.5e-05
                 EEEEEESSHHHHHHHHHT.........TESEEEET..........TTCHHHHHHHHHTT..TSSEEE.....EEESSC.SHHHHHHHHHCEEEEEEEEE CS
  ADH_zinc_N  16 eviavdsseeklelakkl.........Gadeviny..........keadlverikeltg..gegvdv.....vfecvG.sgatleaalkllkpgGrlvv 87 
                 +vi+vd +++++e+a+++                +          +   l e++ ++ g   e +d+     v++ +   +++l++ +k+lk gG +v+
  EFC37377.1  90 KVIGVDMTKSQVEQAREFtpkfiesikN------AnmniakiefhE--GLIEELDQIPGvtSESIDLitsncVINLSPkKEQVLRQVYKVLKFGGEFVF 180
                 89***************94444443332......144444465531..2333333333222444444333338888877899***************** PP

                 CSCTSSEEEEEHHHHHHTT-EEEEE-SSC CS
  ADH_zinc_N  88 vGggkgeeefdlrnlllkeksilGsllgs 116
                   + ++    ++ + +++++silGs  g+
  EFC37377.1 181 SDIYSDR---KIHPAAREKLSILGSCIGT 206
                 9974443...4677778999999999887 PP

>> HMA  Heavy-metal-associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0    0.0003      0.45      18      56 ..     133     168 ..     131     174 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.0003
         HMA  18 kvLselpgVesvkvdlatktvtVegdaestklrkiieai 56 
                 + L  +pgV+s ++dl t+ +++++++ +   +++++++
  EFC37377.1 133 EELDQIPGVTSESIDLITSNCVINLSPKK---EQVLRQV 168
                 57899***********************9...8888777 PP

>> DUF5502  Family of unknown function (DUF5502)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.2    0.0073        11      32      65 ..     114     147 ..      97     162 .. 0.84
   2 ?    3.2   0.0     0.099   1.5e+02      12      49 ..     184     229 ..     179     243 .. 0.69
   3 ?   -2.7   0.0       6.9     1e+04      16      38 ..     295     316 ..     292     323 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0073
     DUF5502  32 eikntnqkihffsikenlfeekgdiagilnedeq 65 
                  ikn+n +i  +  +e l+ee  +i g+  e  +
  EFC37377.1 114 SIKNANMNIAKIEFHEGLIEELDQIPGVTSESID 147
                 69**************************998765 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.099
     DUF5502  12 wkdepfhlsdakeieclgsc........eikntnqkihffsikenl 49 
                 + d  +h +   ++  lgsc        +  nt +ki f  i+en 
  EFC37377.1 184 YSDRKIHPAAREKLSILGSCigtvyyvnDFLNTCRKIGFDVIRENS 229
                 66677777777777778887544444444679999*****999994 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 6.9
     DUF5502  16 pfhlsdakeieclgsceikntnq 38 
                  fh  + ke   +g +e+k+   
  EFC37377.1 295 EFHYGEFKES-SIGQVEVKQVTF 316
                 5888888884.689999987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       689  (0.0384294); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 2027.64
//
Query:       EFC37378.1  [L=208]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.1e-57  192.7   2.2    3.7e-57  192.4   2.2    1.0  1  Ras              Ras family
    1.5e-34  118.7   1.2    2.5e-34  118.0   1.2    1.3  1  Roc              Ras of Complex, Roc, domain of DAPkinase
    1.8e-16   60.1   1.2    2.3e-16   59.8   1.2    1.0  1  Arf              ADP-ribosylation factor family
    1.5e-08   34.3   0.3    1.8e-08   34.1   0.3    1.1  1  Gtr1_RagA        Gtr1/RagA G protein conserved region
     0.0001   21.9   1.4    0.00018   21.1   1.4    1.5  1  GTP_EFTU         Elongation factor Tu GTP binding domain
    0.00021   21.3   0.2    0.00039   20.5   0.2    1.4  1  MMR_HSR1         50S ribosome-binding GTPase
    0.00036   20.5   1.1       0.58   10.0   0.1    2.3  2  RsgA_GTPase      RsgA GTPase
     0.0017   17.8   0.2     0.0022   17.5   0.2    1.2  1  SRPRB            Signal recognition particle receptor beta su
      0.003   16.9   0.3     0.0054   16.1   0.2    1.4  1  ArabFuran-catal  Alpha-L-arabinofuranosidase B, catalytic
  ------ inclusion threshold ------
      0.011   15.5   0.5       0.44   10.3   0.1    2.8  3  PduV-EutP        Ethanolamine utilisation - propanediol utili
      0.023   15.1   0.5       0.34   11.3   0.4    2.3  1  AAA              ATPase family associated with various cellul
      0.035   14.5   0.0      0.047   14.1   0.0    1.4  1  AAA_16           AAA ATPase domain
      0.058   12.6   0.1       0.13   11.4   0.0    1.6  2  DUF815           Protein of unknown function (DUF815)
      0.071   12.6   0.0       0.14   11.7   0.0    1.5  1  AAA_7            P-loop containing dynein motor region
       0.14   12.1   0.0       0.29   11.1   0.0    1.5  2  NACHT            NACHT domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  192.4   2.2   3.1e-60   3.7e-57       1     161 [.      38     203 ..      38     204 .. 0.97

  Alignments for each domain:
  == domain 1  score: 192.4 bits;  conditional E-value: 3.1e-60
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++l+Gd +vGKtsl +++v+++F+e+y++Tigvdf++k++++d++ +kl+iwDTAGqe++++++ +yyr++ g+l+vyd+t++esf+nv+kw+++i++
  EFC37378.1  38 KILLLGDAGVGKTSLAIKWVDGSFQENYIATIGVDFKKKDVTIDNQMIKLQIWDTAGQERYNTIQATYYRGCAGVLVVYDMTDSESFQNVQKWITNIEK 136
                 89************************************************************************************************* PP

                 HST..TTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHTS...EEEEEBTTTTCTHHHHHHHHHHHHH CS
         Ras 100 vae..envpivLvGnKvDleekravsteegeelakelgl...kfletSAktnenveeafeellreil 161
                  ++  ++++++LvGnK+Dl+++r+v+tee+++++k++++   + +e+SAk+ +nv++af++l+++i+
  EFC37378.1 137 NTSpqDDITVLLVGNKADLADERMVKTEEANAFCKNTSCvvdRVFEVSAKSGQNVNDAFMALVEAIH 203
                 9999999*****************************995344689******************9986 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.0   1.2   2.1e-37   2.5e-34       1     120 []      38     155 ..      38     155 .. 0.89

  Alignments for each domain:
  == domain 1  score: 118.0 bits;  conditional E-value: 2.1e-37
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K++l+Gd+gvGKtsl+ ++v+++f+e++ +tigvdf++k+v +i++       + +kl+iWDtaGqer+++++  y+r+ a +++vyd   s+s++n++
  EFC37378.1  38 KILLLGDAGVGKTSLAIKWVDGSFQENYIATIGVDFKKKDV-TIDN-------QMIKLQIWDTAGQERYNTIQATYYRGCAGVLVVYDmtdSESFQNVQ 128
                 9*************************************998.4433.......3599******************************976677889*** PP

                 HHHHHHHHHCS...SS-EEEEEE-TTT CS
         Roc  97 eWlkelkkvag...kspvilvgnkiDl 120
                 +W+++++k+++   ++ v+lvgnk+Dl
  EFC37378.1 129 KWITNIEKNTSpqdDITVLLVGNKADL 155
                 *******996533245789******95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.8   1.2   1.9e-19   2.3e-16      11     174 ..      33     201 ..      27     202 .. 0.81

  Alignments for each domain:
  == domain 1  score: 59.8 bits;  conditional E-value: 1.9e-19
                 .TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSS..EEEEEEEE..TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHH CS
         Arf  11 kkkelrilllGLDnaGKtTilkklkleelvt.tvPTig..fnveelei..knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeL 104
                 +k  ++illlG  + GKt +  k  ++++++  + Tig  f+ ++++i  + +k+++wD  Gqe+   +  +Y++   +v+ v D +d+e +++ ++ +
  EFC37378.1  33 QKVTYKILLLGDAGVGKTSLAIKWVDGSFQEnYIATIGvdFKKKDVTIdnQMIKLQIWDTAGQERYNTIQATYYRGCAGVLVVYDMTDSESFQNVQKWI 131
                 46679*********************999875889998334556677744669********************************************** PP

                 HHHCTSGCCT.TSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 105 kalleeeelk.evallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlses 174
                 +++ ++   + ++++l+++NK Dl++    +  +++   ++ +      ++++sa +g+++++++  l+e 
  EFC37378.1 132 TNIEKNTSPQdDITVLLVGNKADLADERMVKTEEANAFCKNTS-CVVDRVFEVSAKSGQNVNDAFMALVEA 201
                 ***987776549************8765444333333333333.3445789999999*****999999876 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.1   0.3   1.5e-11   1.8e-08       1     128 [.      38     160 ..      38     202 .. 0.68

  Alignments for each domain:
  == domain 1  score: 34.1 bits;  conditional E-value: 1.5e-11
   Gtr1_RagA   1 kvLLmGksgsGKtsmr.siiFdnylardtlrlgatidveksevrf.lgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedlet 97 
                 k+LL+G  g GKts+  + +   ++ + + ++g  +d +k++v + ++ ++l++wD  Gqe++ +      +++ +r ++ ++ V D++++e   ++++
  EFC37378.1  38 KILLLGDAGVGKTSLAiKWVDGSFQENYIATIG--VDFKKKDVTIdNQMIKLQIWDTAGQERYNTI-----QATYYRGCAGVLVVYDMTDSE---SFQN 126
                 89************9624555555555555555..566666666515566**********998665.....4778999999999*****665...4555 PP

   Gtr1_RagA  98 lkeilealrq.yspeakvfvli..hKmDliqede 128
                  ++ ++++ + +sp+  + vl+  +K Dl +e+ 
  EFC37378.1 127 VQKWITNIEKnTSPQDDITVLLvgNKADLADERM 160
                 5555555543146666666665449***986432 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   1.4   1.5e-07   0.00018      57     192 ..      74     202 ..      36     205 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 1.5e-07
                 SCEEEEEETTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTBSTHHHHHHHHHHHHTTTE......EEEEEESCGSTHHHHHHHHHHHHHH CS
    GTP_EFTU  57 ksaaisleketkkylinliDtPGHvdFskevirglrvlDgavlvvdaveGvepqteevlrlalkegvp......iivfiNKmDrlkaelkeiveevkqk 149
                 k + ++++   +  ++++ Dt G + ++    + +r + g+++v d ++    q  + +   +++++       + ++ NK+D +++++ ++ e+  + 
  EFC37378.1  74 KKKDVTID--NQMIKLQIWDTAGQERYNTIQATYYRGCAGVLVVYDMTDSESFQNVQKWITNIEKNTSpqdditVLLVGNKADLADERMVKTEEA--NA 168
                 44555555..8889999*******************************9955555444444433333324443288888******9998776544..45 PP

                 HHHHHHHHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHHHHHHS CS
    GTP_EFTU 150 lsrkeeklekygekgekevpvvfgSalkgegvktllealvell 192
                 +      +++     +    v+ +Sa++g++v++ + alve +
  EFC37378.1 169 F------CKNTSCVVD---RVFEVSAKSGQNVNDAFMALVEAI 202
                 7......333333333...599999999999997777776655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.2   3.3e-07   0.00039       1     113 [.      38     151 ..      38     152 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 3.3e-07
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETT..EEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.TTCSHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkg..keielvDtpGliegaseekglgkaflaleeadlillvvdas.eeklkpldee 96 
                 +++++G   vGK++L  ++++   + + ++    d +++ v++++   +++++Dt+G  e   + + ++ ++   + +  +l+v d++ +e+++++++ 
  EFC37378.1  38 KILLLGDAGVGKTSLAIKWVDGSFQENYIATIGVDFKKKDVTIDNqmIKLQIWDTAG-QE---RYNTIQATYY--RGCAGVLVVYDMTdSESFQNVQKW 130
                 5899*****************98888888888888888888866645789*******.54...3335555555..3699*******8864556666665 PP

                 HHHHHHH....TTSEEEEEEE CS
    MMR_HSR1  97 leellee....akkplilvln 113
                 + ++ ++    +++ ++lv n
  EFC37378.1 131 ITNIEKNtspqDDITVLLVGN 151
                 555543344434444555555 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.1   0.00049      0.58     101     158 ..      38      92 ..      17     101 .. 0.60
   2 !    9.6   0.1   0.00068      0.81      20      92 ..     113     193 ..      95     204 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00049
                  EEEEECSTTSSHHHHHHH.HCTT-----S--------------SEEEEEETTTEEEESS CS
  RsgA_GTPase 101 tsvlvGqSGvGKStLina.llpelelktgevseklgrGkhTTtavellelaegglliDt 158
                   ++l+G  GvGK++L  + ++++ + +  ++   + + k  T   ++++l+    + Dt
   EFC37378.1  38 KILLLGDAGVGKTSLAIKwVDGSFQENYIATIGVDFKKKDVTIDNQMIKLQ----IWDT 92 
                  45799**********654044444444333334444446666666666666....5555 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00068
                  EEEEESTTTT--HHHHHHHHHHHHHT.....T-EEEEEEE-GGG--HHH....HHHHHHHHHHHTTSEEEE--TTTHTTHHH CS
  RsgA_GTPase  20 livvslkepelslnlldrfLvlaeek.....giepvivlnKiDlleeee....eleelkeelealgyevllvsaktkeglee 92 
                  l+v  ++ ++ s + +++ ++ +e++     +i++++v nK+Dl++e+     e++++ ++++ +  +v+ vsak+++++++
   EFC37378.1 113 LVVYDMT-DSESFQNVQKWITNIEKNtspqdDITVLLVGNKADLADERMvkteEANAFCKNTSCVVDRVFEVSAKSGQNVND 193
                  5555555.55566667777777765422222799*************99755455555555555556788888888888765 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.2   1.8e-06    0.0022       5     128 ..      38     159 ..      34     196 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.8e-06
                 EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG.....GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHHH CS
       SRPRB   5 avllvGlsdsGKTslftrLttdsvkktvtSq.essaalkv..ksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAElly 100
                 ++ll+G    GKTsl  +   +s+++ +++     + +k    +++  kl++ D  G+e+  +  ++   + +   g++ v D t d+   ++v  +++
  EFC37378.1  38 KILLLGDAGVGKTSLAIKWVDGSFQENYIATiGVDFKKKDvtIDNQMIKLQIWDTAGQERYNT--IQA-TYYRGCAGVLVVYDMT-DSESFQNVQKWIT 132
                 79***********************9999885444544432346667788999****997654..555.4677888888788866.89999******** PP

                 HHHHHHHHHTT---EEEEEE-TTSTT-- CS
       SRPRB 101 eilliteklkdavdiliACnKqelflak 128
                 +i  +t   +d +++l+  nK +l+  +
  EFC37378.1 133 NIEKNTS-PQDDITVLLVGNKADLADER 159
                 *988776.8999**********997655 PP

>> ArabFuran-catal  Alpha-L-arabinofuranosidase B, catalytic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.2   4.5e-06    0.0054      51      81 ..     159     189 ..     134     206 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 4.5e-06
  ArabFuran-catal  51 gvanaaaqdsFCagttCvitiiYDqsgkgnd 81 
                       + +++++++FC++t+Cv+ ++++ s+k ++
       EFC37378.1 159 RMVKTEEANAFCKNTSCVVDRVFEVSAKSGQ 189
                      56678899*****************997654 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.1   0.00037      0.44       3      38 ..      38      75 ..      36      93 .. 0.73
   2 ?    0.7   0.0      0.34   4.1e+02      84     117 ..     101     133 ..      79     139 .. 0.80
   3 ?    1.2   0.0      0.23   2.8e+02      98     138 ..     152     195 ..     142     200 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00037
   PduV-EutP  3 killiGkvgsGKttLtqalkg..eelkYkktqaiefsd 38
                kill+G  g+GKt+L+ +  +   + +Y  t  ++f++
  EFC37378.1 38 KILLLGDAGVGKTSLAIKWVDgsFQENYIATIGVDFKK 75
                8**************87655512233566666666654 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.34
   PduV-EutP  84 fasvfnkeviGiitkidlaedeenieaveelLks 117
                 ++++  + + G++   d++ d+e+ ++v++++++
  EFC37378.1 101 IQATYYRGCAGVLVVYDMT-DSESFQNVQKWITN 133
                 5566778889999999999.99999999999876 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.23
   PduV-EutP  98 kidlaedeeni..eaveelLksaG..aekifevsavekegieell 138
                 k+dla de  +  e ++ + k+    ++++fevsa + +++++ +
  EFC37378.1 152 KADLA-DERMVktEEANAFCKNTScvVDRVFEVSAKSGQNVNDAF 195
                 66666.333330034444444443116899****99999998765 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.4   0.00029      0.34       1     120 [.      39     161 ..      39     174 .. 0.57

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00029
                 EEEESSTTSSHHHHH.HHHHHHHTHEEEEEETTTCSSS.............STTHHHHHHHHHHHHHHHTSTSEEEEE.ETGGGHHHHHTTCCCHHHHH CS
         AAA   1 vllyGppGtGKTlla.kavakelgvefleisgsellsk.............yvgesekkirelfkeakekakpsilfi.DEidalaksrsgseseeeer 84 
                 +ll G  G+GKT+la k v  +++ +++ + g ++ +k             +  +++++ + + ++  +     +l++ D  d+   ++          
  EFC37378.1  39 ILLLGDAGVGKTSLAiKWVDGSFQENYIATIGVDFKKKdvtidnqmiklqiWDTAGQERYNTIQATYYRG-CAGVLVVyDMTDSESFQN---------- 126
                 699*********9983666667788888888888876666666666666652222222222222222111.123443303333333333.......... PP

                 HHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHHH CS
         AAA  85 vvnqLlteldgvkkkeskvivigatnrpdkldpall 120
                  v++ +t +++ ++ +++++v++++n+ d  d+ ++
  EFC37378.1 127 -VQKWITNIEKNTSPQDDITVLLVGNKADLADERMV 161
                 .66666666666666666777777776666666655 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0     4e-05     0.047      27      61 ..      39      74 ..      31     207 .. 0.62

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 4e-05
      AAA_16 27 vllsGesGvGKsslvrellr.alekdggiflrgkcd 61
                +ll G++GvGK+sl+ ++ + +++++++ ++  +++
  EFC37378.1 39 ILLLGDAGVGKTSLAIKWVDgSFQENYIATIGVDFK 74
                79************9555442666665444333333 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00011      0.13      47      88 ..      30      72 ..      14      92 .. 0.80
   2 ?   -2.2   0.0       1.6   1.9e+03      32      44 ..     126     138 ..     108     169 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00011
      DUF815 47 fleglpannvLLwGarGtGKSsl.vkallneyaeegLrlieve 88
                 +e++ + ++LL G+ G+GK sl +k +  +++e+ ++ i v+
  EFC37378.1 30 VVEQKVTYKILLLGDAGVGKTSLaIKWVDGSFQENYIATIGVD 72
                577788899***********99768999999999999998775 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.6
      DUF815  32 gidkqkealvent 44 
                 +++k  +++ +nt
  EFC37378.1 126 NVQKWITNIEKNT 138
                 3333333333333 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00011      0.14      33      70 ..      36      74 ..      30      91 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00011
       AAA_7 33 kkpvllvGptGtGKtviikd.llkkldkekylsltinfs 70
                 +++ll G++G+GKt+++ + +  +++++ + ++ + f+
  EFC37378.1 36 TYKILLLGDAGVGKTSLAIKwVDGSFQENYIATIGVDFK 74
                5789*************9995666666555556666665 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00024      0.29       3      20 ..      39      56 ..      37      67 .. 0.85
   2 ?   -3.1   0.0       5.4   6.5e+03     105     118 ..     127     140 ..     115     173 .. 0.57

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00024
                EEEEC-TTTCHHHHHHHH CS
       NACHT  3 vilqGeaGsGKTtLlqkl 20
                ++l G+aG+GKT L+ k 
  EFC37378.1 39 ILLLGDAGVGKTSLAIKW 56
                789***********9765 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 5.4
                 ....HHHHHCTTTT CS
       NACHT 105 vrtlLselirkkll 118
                 v+++++++ + +++
  EFC37378.1 127 VQKWITNIEKNTSP 140
                 44444333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1122  (0.0625802); expected 358.6 (0.02)
Passed bias filter:                      587  (0.0327403); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.57
# Mc/sec: 1100.21
//
Query:       EFC37379.1  [L=373]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    8.7e-72  241.5  17.4    1.5e-71  240.8  17.4    1.4  1  NAP         Nucleosome assembly protein (NAP)
  ------ inclusion threshold ------
        1.1    8.6   4.1       0.17   11.3   0.3    1.5  2  A_deamin    Adenosine-deaminase (editase) domain


Domain annotation for each model (and alignments):
>> NAP  Nucleosome assembly protein (NAP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  240.8  17.4   1.7e-75   1.5e-71       4     268 ..      63     325 ..      60     327 .. 0.87

  Alignments for each domain:
  == domain 1  score: 240.8 bits;  conditional E-value: 1.7e-75
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT--S.............................--SSSSTTSTTHHHHHHHTSHHH CS
         NAP   4 eaLkklqkelskleaefqeevlelekkyaalykplyekrseIingesepteeeveakedekeeeeeeeekeeekeeekkeeakgipeFWltvlknvell 102
                  +Lk+lq+++s+le++f+ee l+l++kyaaly+p++ +r+eI++ge+e t+ee+++             + +e ++ek+e+ kg+p+FW++vl ++e+ 
  EFC37379.1  63 GVLKNLQQKYSDLEKQFEEEYLKLREKYAALYAPVIIRRNEIVTGEVEATSEELSTV------------ALSEVTTEKTEDLKGVPDFWYKVLLHSEIK 149
                 689***************************************************433............33456678899******************* PP

                 HTT--HHHHHHHTTEEEEEEEE-----....................--EEEEEEEE-S-SSB--SEEEEEEEE----........----EEEEEE--- CS
         NAP 103 aeliqerDepiLkhLkdirveyllske....................kegFtleFeFdeNpyFtnevLtktyilksevdkedpfiydgpeiekaegckI 181
                 aeliqe D ++Lk+Lk++ +e +  k                     ++gF++ F+F+eNp+Ftn++L+k+y+++ e         d ++i ++eg++I
  EFC37379.1 150 AELIQEDDLEALKFLKNVVMEEFPAKPkeesaekkeeeeeeeidykhNPGFRIIFQFNENPFFTNTQLVKSYYYE-EA--------DSEDIATSEGTEI 239
                 *********************98776677888877776666555555555*************************.33........34458899***** PP

                 -B-TT--TTS----------...-------------GGGGS--B---------------HHHHHHHHHHHHHHHHHTHHHHHHHHHH CS
         NAP 182 dWkegkdvtvktvkkkqknkktketrtvtkkvpkeSFFnfFsppkvpeeeeeeeeeeeeleelleadyeigealkdkiiPkAveyFt 268
                 +W egkd+tvk+++kkqk+k+ ++trt++ k+pk+SFFnfF++ +++ + +ee+ee+  l+ellead eig +lk++iiP+Av+yF+
  EFC37379.1 240 TWAEGKDLTVKVTTKKQKHKSGNRTRTIQVKEPKDSFFNFFKNLDEEIQ-KEENEENMILQELLEADAEIGDILKERIIPNAVDYFL 325
                 ******************************************6433222.224455666779************************8 PP

>> A_deamin  Adenosine-deaminase (editase) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.3      0.77   6.9e+03     298     315 ..      64      81 ..      38      90 .. 0.58
   2 ?   11.3   0.3   1.9e-05      0.17     205     294 ..     209     296 ..     201     307 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 0.77
    A_deamin 298 eaKeaakeYqeakkqlkk 315
                  +K++ ++Y+   kq+ +
  EFC37379.1  64 VLKNLQQKYSDLEKQFEE 81 
                 445555555555555544 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 1.9e-05
    A_deamin 205 kpyrvnkpll.sllseeeskrktakaknlsinWsavdeelevvdattGkrqgttkkklgspqasrlckaelferfkkllsslseeklkasl 294
                 +p+ +n+ l+ s   ee+++++ a+++ + i W+ +++  ++v++tt k+++++ +++++  + +  k ++f+ fk+l +++++e++++++
  EFC37379.1 209 NPFFTNTQLVkSYYYEEADSEDIATSEGTEITWAEGKD--LTVKVTTKKQKHKSGNRTRTI-QVKEPKDSFFNFFKNLDEEIQKEENEENM 296
                 5566666666455555555788999999********99..555553333333333333443.58889*****************9998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (373 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1656  (0.0923643); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2293.35
//
Query:       EFC37380.1  [L=167]
Description: hypothetical protein NAEGRDRAFT_81953 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.033   13.2   7.3      0.038   13.0   7.3    1.1  1  Miga      Mitoguardin
        4.1    6.9   9.1        5.2    6.5   9.1    1.0  1  SMYLE_N   Short myomegalin-like EB1 binding proteins, N-termi
        6.2    5.3  13.7        7.6    5.0  13.7    1.2  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> Miga  Mitoguardin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   7.3   6.4e-06     0.038      63     199 ..       4     142 ..       1     150 [. 0.62

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 6.4e-06
        Miga  63 vkkrasekksrssssksndtlslasskassssaklsgslqslasvksvnsssssaaan.saswdkeeeeelklenitvltpenlyl.mGmelleealrr 159
                 +k+ras+k+++ +s +s  t s++ +++        + +qs +s +s +ss++s+ an + ++d++ ++e + ++i+ +tp++++  mGm  l+  ++ 
  EFC37380.1   4 RKRRASTKRNKPDSPSSSPTPSSSEENN------SPKLKQSTSSASSSSSSKKSTRANlAVAADQKYNDEDMRNSIPFITPQHIKKeMGMMKLNGHVND 96 
                 3444566666666555555555544333......344555666666778888888888777888888888888999*******9752799999888887 PP

        Miga 160 weqa.....Ltvrsr.qaedeascssvklgagdaiaeeevedvksa 199
                  ++      + + ++ +++++ s +s+ +++ +  +++++++++++
  EFC37380.1  97 LDNCfsensILFGKEiNSSRKRSIVSIVHQQDENFKKSHLKQSNNS 142
                 6554111113333331445666777777777777777777766655 PP

>> SMYLE_N  Short myomegalin-like EB1 binding proteins, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   9.1   0.00087       5.2     202     347 ..       7     152 ..       2     166 .. 0.55

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.00087
     SMYLE_N 202 rysasvgeeeeavselaaaelaeaksssegesleeespas.svesLdtavdvvkpakkkeeesekeakedeksdslseekteaesslsgsklelalsl. 298
                 r s+  ++ ++ +s++++++++e++s++ ++s+++ s++s s +s  ++  v++ + k ++e+ +++    + +++++e      +l+g+  +l  ++ 
  EFC37380.1   7 RASTKRNKPDSPSSSPTPSSSEENNSPKLKQSTSSASSSSsSKKSTRANLAVAADQ-KYNDEDMRNSIPFITPQHIKKE--MGMMKLNGHVNDLDNCFs 102
                 44444455556667777777777777777777665544441444444444433322.2333344444445555555555..333445555555555550 PP

     SMYLE_N 299 .lkaleyrpvksargsklpvlvksklsesklkksvlegskaaalsletse 347
                     l  + ++s r+  +  +v+++ ++ k ++  +++++++++ + +++
  EFC37380.1 103 eNSILFGKEINSSRKRSIVSIVHQQDENFKKSHLKQSNNSTSCVLIGAKK 152
                 05555789999999999999999988888887665555544444444333 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0  13.7    0.0013       7.6     309     411 ..      11     100 ..       1     160 [. 0.38

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0013
    Macoilin 309 ellveesvkskssssssssnknskkasagsagssnssskkhsessksvtsssssknskkqklpaGkssaalkdaaenslp...nnqlskkdalvrLead 404
                 + ++ +s +s+ ++sss++n++ k ++++s++ss+ssskk  +++  v+                  ++ + + + ns+p    +++ k+  +++L++ 
  EFC37380.1  11 KRNKPDSPSSSPTPSSSEENNSPKLKQSTSSASSSSSSKKSTRANLAVA----------------ADQKYNDEDMRNSIPfitPQHIKKEMGMMKLNGH 93 
                 2222333333333444444333333333333344444444444444443................3333333333443331111222222222233333 PP

    Macoilin 405 ikkLkae 411
                 ++ L   
  EFC37380.1  94 VNDLDNC 100
                 3332222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1881  (0.104914); expected 358.6 (0.02)
Passed bias filter:                      635  (0.0354175); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1022.22
//
Query:       EFC37381.1  [L=405]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-07   31.4   1.9    4.6e-07   30.0   1.3    1.9  2  Peptidase_M54  Peptidase family M54
  ------ inclusion threshold ------
       0.13   12.0   0.0       0.29   10.9   0.0    1.5  1  Sharpin_PH     Sharpin PH domain


Domain annotation for each model (and alignments):
>> Peptidase_M54  Peptidase family M54
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.21   1.9e+03      66     107 ..     171     213 ..     160     219 .. 0.76
   2 !   30.0   1.3   5.1e-11   4.6e-07     132     191 ..     260     320 ..     244     323 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.21
                    TEEEHHHHHHHHHT--S--..SEE..........EEEESS-EE- CS
  Peptidase_M54  66 leavveallgkLkemkddvndDsitkifgitt..lplgsrdqyi 107
                    +++ +  ++  L+++++++ +D+++ + g+t   l +g +d + 
     EFC37381.1 171 IQFRAADVIVPLNKLRKHL-QDEVSCVCGVTMddLYIGAKDSFT 213
                    6677777888899999777.888989999985448888888775 PP

  == domain 2  score: 30.0 bits;  conditional E-value: 5.1e-11
                    .....SHHHHHHHHHHHHHHHHHHHTT----S-.TSTTS--SSHHHHHHS-SS--HHHHHH CS
  Peptidase_M54 132 efytedkeLflervvkevlhelGhlyGLshCke.dCvmnfsndlkdvDrkapkyCksClek 191
                    +  te+  + ler  k v+he+ h+  ++hC   dC+mn s  l++  r++ + C   l+k
     EFC37381.1 260 DTLTENDLVILERCCKIVVHEIAHMVQVGHCVFfDCIMNGSGHLEEDFRQSIHLCPVDLRK 320
                    4578888999**********************99***********9989998888766665 PP

>> Sharpin_PH  Sharpin PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   3.2e-05      0.29      68      96 ..     146     174 ..     127     178 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 3.2e-05
  Sharpin_PH  68 LesvsYevkspkcHElqlvappedrlsln 96 
                  e++ Y +ks +cHE    + +ed + ++
  EFC37381.1 146 SEDIIYRIKSRRCHEYDEDKAGEDEIQFR 174
                 5799********************99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       972  (0.0542138); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 2618.59
//
Query:       EFC37382.1  [L=481]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.9e-45  154.2  15.6      3e-41  141.2  10.8    2.5  3  Chromate_transp  Chromate transporter
  ------ inclusion threshold ------
      0.074   12.4   0.3        5.2    6.4   0.0    3.0  3  DUF5305          Family of unknown function (DUF5305)


Domain annotation for each model (and alignments):
>> Chromate_transp  Chromate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.1   4.7e-09   4.2e-05      68     154 ..       4     119 ..       2     122 .. 0.79
   2 ?   -4.4   1.8         2   1.8e+04     138     151 ..     211     217 ..     197     227 .. 0.42
   3 !  141.2  10.8   3.4e-45     3e-41       3     156 ..     254     473 ..     252     475 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 4.7e-09
  Chromate_transp  68 lgvlGaliatlgfflPsfllilllaplleklrk...nplvkaaleglnaavvglilaaalslakk........................ialla 134
                      +g+ G++++ l+f +P+f++ l+l   +  + +    +++ +a +gl +  +++ l+ + ++ +                         ++++a
       EFC37382.1   4 YGFSGGILSYLFFSIPGFIVCLVLGLSMYDYDSstaPQWFIHAQKGLACSGIAFALQSMSRFSSMldnekkkkgqpkkekkpemfpyilLTIVA 97 
                      5999*******************9988888877544477889999999999999999998543335568888999999999****998866777 PP

  Chromate_transp 135 flllllfkvs..pilvillaal 154
                      ++ ll+ k +  p+l++++a+l
       EFC37382.1  98 MVTLLYRKTWllPVLLVIGAIL 119
                      7777777888766666666655 PP

  == domain 2  score: -4.4 bits;  conditional E-value: 2
  Chromate_transp 138 lllfkvspilvill 151
                      +l       ++ill
       EFC37382.1 211 IL-------FFILL 217
                      11.......11122 PP

  == domain 3  score: 141.2 bits;  conditional E-value: 3.4e-45
  Chromate_transp   3 lflfflkiGllifGGgyavipllreevverkgwlteeefldglalaqalPGPiavnlatfvGylilgvlG........................ 72 
                      +++ff+k+G+lif+G+++++ ++r+e++e +gw+t+e+f++g++l++a+PGP + nl +++G++++   G                        
       EFC37382.1 254 MSSFFFKSGSLIFNGAVVNVVIIRDEMIE-RGWITPEQFINGYSLTNAAPGPRF-NLGFYFGSVVA---Gnllnsnytsslykdvtnstisfde 342
                      889**************************.66*********************9.********955...4444899999999999999999999 PP

  Chromate_transp  73 ....................................aliatlgfflPsfllilllaplleklrknplvkaaleglnaavvglilaaalslakk. 129
                                                          ++ia+++f++P+fllil+++pl+ +lr++p+v++a++g+na++vg+++++++ l+ + 
       EFC37382.1 343 isnnnfigfsnnetlnssveessvspftkfiiviiySMIAGISFHAPGFLLILGIVPLWGSLRSKPIVQKAMNGINAVCVGYLINNIVILWISv 436
                      99999999***************************9**************************99************************775557 PP

  Chromate_transp 130 .........iallaflllllfkvs.pilvillaallg 156
                               +++l+f+l+++++++ p++v+++a++++
       EFC37382.1 437 vglsvplaaVSILGFALVNWIDFWhPLVVFVGAIAAV 473
                      88889999899***********998888887777664 PP

>> DUF5305  Family of unknown function (DUF5305)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0     0.053   4.7e+02      98     128 ..      73     102 ..      61     132 .. 0.67
   2 ?    6.4   0.0   0.00059       5.2     106     165 ..     196     255 ..     174     264 .. 0.76
   3 ?    1.6   0.0     0.017   1.5e+02      68     128 ..     319     384 ..     305     391 .. 0.71

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.053
     DUF5305  98 ngeitetvtvkespslaegilliilgllali 128
                 +++    +++k+++++++ ill+i+++++l+
  EFC37382.1  73 KKKKGQPKKEKKPEMFPY-ILLTIVAMVTLL 102
                 333333344444444444.566666555554 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.00059
     DUF5305 106 tvkespslaegilliilgllaliglvvlirriiftsskaekyelelekilkeYdewIvkg 165
                    +  s++ g++l+il ++ l++l+ +++    ts   +  ++  ++ ++   ewI+  
  EFC37382.1 196 PFAKMASIKLGVFLFILFFILLGCLIGAALIVESTSPTVKLSNQVEKRKINLWTEWIIMS 255
                 445566677799999999999999999999988888888888888899999999999865 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.017
     DUF5305  68 esieesktsrlpiplteqtyeikkdetd.....eengeitetvtvkespslaegilliilgllali 128
                 +  + ++ts+l  ++t++t+++++ +++     ++n++++ +v+++    ++++i++ii++++a i
  EFC37382.1 319 NLLNSNYTSSLYKDVTNSTISFDEISNNnfigfSNNETLNSSVEESSVSPFTKFIIVIIYSMIAGI 384
                 556677777777788889998887766666766677777777777776777776666666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       998  (0.055664); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2762.12
//
Query:       EFC37383.1  [L=478]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (478 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       508  (0.028334); expected 358.6 (0.02)
Passed bias filter:                      311  (0.0173462); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.25s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 3045.89
//
Query:       EFC37384.1  [L=459]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1504  (0.0838864); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.27s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 2935.14
//
Query:       EFC37385.1  [L=909]
Description: hypothetical protein NAEGRDRAFT_81954 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
        0.2   12.0   9.7       0.48   10.7   9.7    1.6  1  Vfa1         AAA-ATPase Vps4-associated protein 1
       0.41    9.7   4.1        1.7    7.6   2.8    2.3  2  Roughex      Drosophila roughex protein
       0.57    8.4   6.3       0.86    7.8   6.3    1.2  1  CDC45        CDC45-like protein
       0.69    9.6   4.3        1.5    8.5   4.3    1.5  1  FAM176       FAM176 family
       0.75    7.8  10.2        1.2    7.2  10.2    1.2  1  DNA_pol_phi  DNA polymerase phi
        3.6    6.8  14.4        5.5    6.2  14.4    1.2  1  NOA36        NOA36 protein


Domain annotation for each model (and alignments):
>> Vfa1  AAA-ATPase Vps4-associated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   9.7   0.00016      0.48      83     157 ..     386     459 ..     365     489 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00016
        Vfa1  83 qkkkkekekkkkekdkkdkdkkkekekdkkkekekeeekkkelkkaeeeleekeeprvkkykLhkefyqsRlerk 157
                 + kkk  +k+ ++kd+k+kd+kke+++d ++  ++e+e+++e +++ +e ++  e+  k y+++k+ ++  ++++
  EFC37385.1 386 MCKKKGGKKD-DKKDDKKKDDKKEDDDDGDEPVHEEDEENQEEQQEFKEGDKFPETVLKGYNINKTNFRGQVQAR 459
                 3333322222.2344455555555555555444445555555555555555567888899*****9999888776 PP

>> Roughex  Drosophila roughex protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0       0.1     3e+02     238     256 ..     252     269 ..     243     274 .. 0.78
   2 ?    7.6   2.8   0.00058       1.7     264     300 ..     392     430 ..     338     459 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.1
     Roughex 238 slsvrrilfadgadedgde 256
                 ++sv+r+lf+  a++dg e
  EFC37385.1 252 KQSVKRVLFT-NAEDDGVE 269
                 689*******.77777766 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00058
     Roughex 264 ekkddasepdlpdqnkeedkd..eqeqqaeqeeqaqqqa 300
                  kkdd  +    d++ke+d d  e+  + ++e+q++qq 
  EFC37385.1 392 GKKDDKKDDKKKDDKKEDDDDgdEPVHEEDEENQEEQQE 430
                 466777777777777777776544333333333333332 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   6.3   0.00029      0.86     134     221 ..     394     495 ..     342     499 .. 0.45

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00029
       CDC45 134 eedeeeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdeeee......sddddersrkrrrse............psakklrrqlkkerrkyea 214
                 ++d+++++++dd++e++++ +e  ++e+e+++e++++ k+ ++  e+           ++++ r + +            + a   +++++++rr ++ 
  EFC37385.1 394 KDDKKDDKKKDDKKEDDDDGDEPVHEEDEENQEEQQEFKEGDKFPETvlkgynI----NKTNFRGQVQarlavitnkalyTFAYDYKKKELTKRRAHRY 488
                 112112211222111111111111111111111122222222222224433221....22222222224455777777776667777777777777777 PP

       CDC45 215 vlekyys 221
                 + +k ys
  EFC37385.1 489 TFDKLYS 495
                 7777776 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   4.3   0.00051       1.5      44      92 ..     384     431 ..     376     456 .. 0.54

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00051
      FAM176  44 riscrkdlerlkkkkkklkeesekasededeeeeeeeedsseseaeeel 92 
                 ++ c+k+  +++ kk+++k++++k+ +d+d +e  +eed++++e+++e+
  EFC37385.1 384 EVMCKKKGGKKDDKKDDKKKDDKKE-DDDDGDEPVHEEDEENQEEQQEF 431
                 5677777776666665555554333.33333332333333333333333 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2  10.2   0.00039       1.2     644     694 ..     393     442 ..     380     463 .. 0.45

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00039
  DNA_pol_phi 644 deeddeeeeeeddeededseedddeeesdedeededdedvdeidelrekla 694
                  +++d+++++++dd++++d++ d+  +e+de++++e++e  +  d+++e + 
   EFC37385.1 393 KKDDKKDDKKKDDKKEDDDDGDEPVHEEDEENQEEQQEFKE-GDKFPETVL 442
                  22222222222222222222222224444444433333333.346666554 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2  14.4    0.0018       5.5     245     305 ..     367     427 ..     355     435 .. 0.49

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0018
       NOA36 245 ddddddeedsdydaylkalasgddeddegdedddddddeedddeeeddedeeeeeeeesee 305
                 d++d ++ d   ++y+k + ++++  ++ d+ dd+++d++++d+++ de  +ee+ee++ee
  EFC37385.1 367 DEADTEAVDICLNTYYKEVMCKKKGGKKDDKKDDKKKDDKKEDDDDGDEPVHEEDEENQEE 427
                 6677777788888888887776433333333333333333333332222222222222211 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (909 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1127  (0.0628591); expected 358.6 (0.02)
Passed bias filter:                      669  (0.0373138); expected 358.6 (0.02)
Passed Vit filter:                       102  (0.00568911); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.89u 0.30s 00:00:01.19 Elapsed: 00:00:00.47
# Mc/sec: 5776.95
//
Query:       EFC37386.1  [L=620]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0033   16.5   0.0      0.011   14.8   0.0    1.8  2  SE              Squalene epoxidase
  ------ inclusion threshold ------
      0.035   13.3   0.0      0.082   12.1   0.0    1.6  1  Pyr_redox_2     Pyridine nucleotide-disulphide oxidoreductase
       0.18   10.6   0.0        8.8    5.1   0.0    2.1  2  Trp_halogenase  Tryptophan halogenase


Domain annotation for each model (and alignments):
>> SE  Squalene epoxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       0.5     3e+03     220     247 ..     427     454 ..     419     459 .. 0.82
   2 !   14.8   0.0   1.8e-06     0.011     125     178 ..     489     542 ..     466     558 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.5
          SE 220 fdYlkrGgecvsgpvallsgllprPllL 247
                 ++ + +G  + + +++ll+ ++  Pl++
  EFC37386.1 427 INIYAKGTPFEKDLIHLLGQMKDVPLSI 454
                 56677899999999********999976 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 1.8e-06
          SE 125 sknekkGlillGDalnmRHPltggGmtvalnDivllskllkpledlsdeekvle 178
                 ++++ +G+i lGD++    P+ + G+t+al+ +++l++ lk+      ++kv++
  EFC37386.1 489 TETRLSGFISLGDSVASLNPVYAQGLTMALESVLILREQLKERYHSLRKSKVSN 542
                 455679**********************************99855445555555 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   1.4e-05     0.082     142     174 ..      35      79 ..       2      87 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.4e-05
                  T............SEEEEES-SHHHHHHHHHHHHHT-EEEEEESS CS
                  x............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 142 p............krivvvGgGyiGvElAaalaklgkevtlvear 174
                  p            +r+v++Gg+  G+ +A+ la + kev++ve+ 
   EFC37386.1  35 PmisertidtvvgERAVIIGGSISGLLTASCLAPFFKEVVIVERT 79 
                  155555555555699****************************96 PP

>> Trp_halogenase  Tryptophan halogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.0    0.0015       8.8       3      34 ..      51      79 ..      49      94 .. 0.84
   2 ?    3.4   0.0    0.0046        28     311     354 ..     489     532 ..     471     580 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0015
                    EEE--SHHHHHHHHHHHHHTTTSSEEEEEE-S CS
  Trp_halogenase  3 vivGGGtaGwlaAaalakalkgklevtlvese 34
                    vi+GG ++G l+A+ la  +k   ev +ve  
      EFC37386.1 51 VIIGGSISGLLTASCLAPFFK---EVVIVERT 79
                    9*******************4...58888865 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.0046
                     S-SEETTEEE-CCCTEE--CCCS-HHHHHHHHHHHHHHT--BTT CS
  Trp_halogenase 311 kqawvknvvalGlasgfvePlestsihliqaalrrLlallpdks 354
                     +++   ++++lG++ ++++P+ ++++ ++ +++  L + l ++ 
      EFC37386.1 489 TETRLSGFISLGDSVASLNPVYAQGLTMALESVLILREQLKERY 532
                     55566789**********************99999888877664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (620 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       536  (0.0298957); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.48
# Mc/sec: 3896.15
//
Query:       EFC37387.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3645  (0.203302); expected 358.6 (0.02)
Passed bias filter:                      866  (0.0483016); expected 358.6 (0.02)
Passed Vit filter:                       628  (0.0350271); expected 17.9 (0.001)
Passed Fwd filter:                       219  (0.0122148); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.93u 0.40s 00:00:02.33 Elapsed: 00:00:00.62
# Mc/sec: 648.18
//
Query:       EFC37388.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-13   50.0   0.1    4.9e-12   45.8   0.1    2.4  1  Pkinase   Protein kinase domain
    0.00097   19.1   0.0     0.0015   18.5   0.0    1.2  1  APH       Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.8   0.1   5.5e-16   4.9e-12      52     198 ..     249     426 ..     220     465 .. 0.70

  Alignments for each domain:
  == domain 1  score: 45.8 bits;  conditional E-value: 5.5e-16
                 HHHHSCTTB--EEEEEEE...SSEEEEEEE.--TTEBHHHHHH..........HHSS--HH......HHHHHHHHHHHHHHHHHHTT.....EE-SS-S CS
     Pkinase  52 lkklkhpnivrlyevfee...kdelylvle.yveggeladlle..........rkgslsee......eakkiakqilegleylHskg.....iiHrDlK 125
                 l+ ++h+ iv++y+ +      + l+l  + +  +g+l+ + +                e       + k +++q+l  l  lH+++      iH D+K
  EFC37388.1 249 LADTNHKCIVKIYNNIACnncRTPLTLNSQgFYVNGSLTPFTQsdvtlkgiplP-----EYilnhahDKKLLMAQLLVQLYKLHKHSavrlgRIHNDIK 342
                 566777777777776665333222222222244446666666644443233222.....2255544578899************9986666679***** PP

                 GGGEEEETTTEEEE-SGTTSEESSSSCS...........BCTTTSCGGGS-HHHHTT.SCBSHHHHHHHHHHHHHHHHHSS-STT CS
     Pkinase 126 peNiLidekgelKitDFGlakelesssk...........ltsfvgtseYlAPEvlke.neyskkvDvWslGvilyelltgkppfs 198
                 p+Ni +  ++    +DF  +k +++  +           lts  gts + +PE  ++ +++++k+Dv+slG++++++l+ ++   
  EFC37388.1 343 PDNIVVY-DNYPYFIDFEASKTFDKYDTaneqcfddgrvLTSSSGTSSFNPPEKGSAlRGITPKSDVYSLGLVFIQILSTHNSTV 426
                 ******9.99*************99888999**********************99553888***************998776555 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   1.7e-07    0.0015     154     196 ..     322     361 ..     298     365 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.7e-07
                 HHHHHH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 154 aalaallpgelptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                 +  + + +++++ + +H+D++p+N++v   d+   ++iDfe +
  EFC37388.1 322 QLYKLHKHSAVRLGRIHNDIKPDNIVVY--DNYP-YFIDFEAS 361
                 44455566699*****************..5554.7****966 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       912  (0.0508673); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3031.50
//
Query:       EFC37389.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0031   17.1   0.0     0.0065   16.1   0.0    1.6  1  Ras       Ras family
  ------ inclusion threshold ------
      0.073   13.1   0.3          8    6.6   0.1    2.3  2  Crl       Sigma factor-binding transcriptional regulator Crl


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   7.2e-07    0.0065       5     111 ..     145     250 ..     141     286 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 7.2e-07
                 EESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEE.EEET..TSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHH CS
         Ras   5 vGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevklei.wDTA..Gqeefkslrelyyrdaegillvyditsresfenvkkwveeikrv 100
                 +G+ ++GK+++ ++   +++++++      +  +ke+++++++  +++ +D     q + +++ +  +r+ + +ll + i+ + +fe++ +w++ ik+ 
  EFC37389.1 145 IGEHSIGKSTFFNHVQFGHYENTSLWKS--EAIKKEFTISNESSLVQVlFDLDprYQTK-ETFIRGLIRHNMSFLLSFGINYECTFEKLGDWYHLIKQE 240
                 9*********999888888888766554..89999999999888888734554003433.456678899****************************99 PP

                 STTTSEEEEEE CS
         Ras 101 aeenvpivLvG 111
                 + e +  +++G
  EFC37389.1 241 KLE-TMGIMIG 250
                 986.4444555 PP

>> Crl  Sigma factor-binding transcriptional regulator Crl
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.1   0.00089         8      62      89 ..     153     180 ..     147     201 .. 0.83
   2 ?    4.4   0.0    0.0041        37      51     108 ..     230     286 ..     217     294 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.00089
                 TEEEEEEEEEEE-TTS-EESEEE--HHH CS
         Crl  62 eefeyeyqlGlydkegeWkaekikkkev 89 
                 ++f  + q+G+y+++  Wk+e+ikk+ +
  EFC37389.1 153 STFFNHVQFGHYENTSLWKSEAIKKEFT 180
                 5788899****************99755 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0041
                 EEEEEEEEEETTEEEEEEEEEEE-TTS-EESEEE--HHHHHHHHHHHHHHHHHHHHHH CS
         Crl  51 wGWWleleaeeeefeyeyqlGlydkegeWkaekikkkeveeklektleefhkkleall 108
                 +G W +l ++e+  ++   +Gl+ +  + ++ ++kk + +e ++k+++ef k l   +
  EFC37389.1 230 LGDWYHLIKQEKLETMGIMIGLHPH-RQITNYELKKINPREVVRKAFHEFGKLLVVEV 286
                 799******************9875.57899999*******9********98887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       713  (0.039768); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 1924.07
//
Query:       EFC37390.1  [L=246]
Description: hypothetical protein NAEGRDRAFT_74967 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.01   16.1   2.1      0.025   14.8   2.1    1.6  1  HALZ       Homeobox associated leucine zipper
      0.021   14.9   0.4      0.054   13.6   0.4    1.6  1  DASH_Dad3  DASH complex subunit Dad3
      0.024   14.5   0.0      0.075   12.9   0.0    1.8  1  F-box      F-box domain


Domain annotation for each model (and alignments):
>> HALZ  Homeobox associated leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   2.1   4.1e-06     0.025      11      32 ..      89     110 ..      81     111 .. 0.94

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.1e-06
        HALZ  11 KasYdaLksdydsLkkenekLk 32 
                 K+++d L s++d L+ ene+L+
  EFC37390.1  89 KRKFDELNSENDELNSENEELE 110
                 89******************97 PP

>> DASH_Dad3  DASH complex subunit Dad3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.4     9e-06     0.054       3      42 ..      79     122 ..      78     124 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 9e-06
   DASH_Dad3   3 pleqevLdeYerLaenlkt....LaselkeLasnsteeildgLR 42 
                 p +q++L+eY+r  ++l++    L+se +eL ++st++i++ +R
  EFC37390.1  79 PKDQNILKEYKRKFDELNSendeLNSENEELETCSTTQITKAFR 122
                 5689*******977777776666****************99988 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   1.2e-05     0.075       4      34 ..       5      37 ..       3      42 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.2e-05
                HHS-HHHHHHHHHTS-HHH..HHHHCTT-HHHH CS
       F-box  4 srLPsevlrhILerLplsd..llalrrVSkgwr 34
                 +LP evl hI+ +++ s   ++++++++k +r
  EFC37390.1  5 HQLPTEVLDHIIFYMGNSAkdVISFSSCCKVLR 37
                68*************999999********9777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (246 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1586  (0.08846); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1546.68
//
Query:       EFC37391.1  [L=946]
Description: alpha-tubulin suppressor domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-39  134.2   6.3    2.5e-07   31.2   0.1    7.7  7  RCC1      Regulator of chromosome condensation (RCC1) repeat
    7.4e-36  121.2   6.5    1.6e-07   30.9   0.1    6.7  6  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    2.1e-12   47.2   1.5    4.2e-09   36.6   0.4    2.8  2  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.0   0.00012      0.69       6      50 .]     130     180 ..     128     180 .. 0.65
   2 !   30.5   0.0   6.9e-11   4.1e-07       3      50 .]     185     237 ..     183     237 .. 0.75
   3 !   16.0   0.0   2.3e-06     0.014       2      48 ..     243     289 ..     242     290 .. 0.89
   4 !   27.5   0.0     6e-10   3.6e-06       3      50 .]     295     345 ..     293     345 .. 0.80
   5 !   31.2   0.1   4.2e-11   2.5e-07       2      50 .]     349     401 ..     348     401 .. 0.89
   6 !   11.6   0.0   5.4e-05      0.32       2      49 ..     405     457 ..     404     458 .. 0.76
   7 ?    2.4   0.1     0.041   2.4e+02       6      45 ..     466     502 ..     463     506 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00012
                 EEE--GGGTTSSSS-.--EEEEEE-GGGTTS........-EEEEEEETTEEEEE CS
        RCC1   6 sWGrndyGqLGlgtt.esvlvPtkveglsgn........rvvkvacGddhtval 50 
                   G+n +G LGlg+   ++    k++++++          v+  acG++ht++l
  EFC37391.1 130 VTGSNMFGMLGLGNPvSDS---AKISSFTRLnnpaidpsQVKFLACGHYHTILL 180
                 569**********997333...34433333334444454555579******875 PP

  == domain 2  score: 30.5 bits;  conditional E-value: 6.9e-11
                 EEEEEE--GGGTTSSSS---E.....EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesv.....lvPtkveglsgnrvvkvacGddhtval 50 
                 ++y++G+n+yGqLG g+  +v      v + ++g +++ ++++ cG +ht+++
  EFC37391.1 185 QLYACGKNNYGQLGMGNLTKVvnifkFVDSSLNGMPKELITDIKCGRYHTMFI 237
                 89****************666333443334444444447************97 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 2.3e-06
                 TEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtv 48 
                 ++V+ +G+n  Gq+ l++ +  + P+++ +  + +v  ++cG+ +t+
  EFC37391.1 243 DNVWVCGKNKTGQMSLPSMNIYPSPQRLITQFSGKVLFASCGSEYTF 289
                 68***********************999555556**********998 PP

  == domain 4  score: 27.5 bits;  conditional E-value: 6e-10
                 EEEEEE--GGGTTSSSS-....--EEE...EEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt....esvlv...PtkveglsgnrvvkvacGddhtval 50 
                 ++y++G n++Gq+G g +    ++ +v   P  ++     ++v++ cG +ht++l
  EFC37391.1 295 HIYACGDNSRGQCGVGIElpqiKKFTVvrdPLFIRQ----DIVQIECGEFHTLFL 345
                 69*************999876433333555777755....************986 PP

  == domain 5  score: 31.2 bits;  conditional E-value: 4.2e-11
                 TEEEEEE--GGGTTSSSS-...--EEE.EEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt...esvlv.PtkveglsgnrvvkvacGddhtval 50 
                 G++++ G   +GqLGl +    +++l+ Ptk++ ++++++++++cG +h+++l
  EFC37391.1 349 GEIWGAGTTVNGQLGLDPVvlgKQNLYsPTKIPVSNNEPIKSISCGFHHSAFL 401
                 8999999999******999998666555********99************986 PP

  == domain 6  score: 11.6 bits;  conditional E-value: 5.4e-05
                 TEEEEEE--GGGTTSSSS---E.....EEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesv.....lvPtkveglsgnrvvkvacGddhtva 49 
                 G+++ +Grn +GqL +g t+ +     ++P   ++l  + v++  c +++++a
  EFC37391.1 405 GKIFICGRNGDGQLATGETVPRlfsftHIPLSASSLGHHFVQDLYCYSYYSIA 457
                 99*****************7775565667887777776677777776666666 PP

  == domain 7  score: 2.4 bits;  conditional E-value: 0.041
                 EEE--GGGTTSSSS-.--EEEEEE-GGGTTS...-EEEEEEETT CS
        RCC1   6 sWGrndyGqLGlgtt.esvlvPtkveglsgn...rvvkvacGdd 45 
                   G+n  GqLG+  t +        e +s++   rv  v cG d
  EFC37391.1 466 LTGSNKCGQLGCLETpKI-------EKFSRTfkhRVMNVYCGRD 502
                 568899999998555322.......2222222337777777765 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.0   3.6e-10   2.1e-06       1      30 []     167     196 ..     167     196 .. 0.94
   2 !   17.8   0.0   3.6e-07    0.0021       1      30 []     224     255 ..     224     255 .. 0.89
   3 !   10.2   0.1   8.7e-05      0.52      14      30 .]     290     306 ..     281     306 .. 0.85
   4 !   21.8   0.1   1.9e-08   0.00012       1      30 []     332     361 ..     332     361 .. 0.92
   5 !   30.9   0.1   2.7e-11   1.6e-07       1      30 []     388     417 ..     388     417 .. 0.99
   6 !   10.6   0.0   6.4e-05      0.38       6      30 .]     450     474 ..     445     474 .. 0.89

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 3.6e-10
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 Vk +++G yH++ Lt ++ ++++G N++GQ
  EFC37391.1 167 VKFLACGHYHTILLTKENQLYACGKNNYGQ 196
                 56689************************9 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 3.6e-07
      RCC1_2   1 VksvsaGdyHscaLte..dGeVlcWGsNsdGQ 30 
                 ++++ +G+yH++++t+  +++V+ +G N  GQ
  EFC37391.1 224 ITDIKCGRYHTMFITNqpNDNVWVCGKNKTGQ 255
                 6899***********955566*******9998 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 8.7e-05
      RCC1_2  14 LtedGeVlcWGsNsdGQ 30 
                 + ++++++++G+Ns+GQ
  EFC37391.1 290 IKTTDHIYACGDNSRGQ 306
                 677889**********9 PP

  == domain 4  score: 21.8 bits;  conditional E-value: 1.9e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++ +G +H+++Lt++Ge+++ G   +GQ
  EFC37391.1 332 IVQIECGEFHTLFLTASGEIWGAGTTVNGQ 361
                 79********************99877777 PP

  == domain 5  score: 30.9 bits;  conditional E-value: 2.7e-11
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +ks+s+G  Hs +Lt +G+++ +G+N+dGQ
  EFC37391.1 388 IKSISCGFHHSAFLTKTGKIFICGRNGDGQ 417
                 89***************************9 PP

  == domain 6  score: 10.6 bits;  conditional E-value: 6.4e-05
      RCC1_2   6 aGdyHscaLtedGeVlcWGsNsdGQ 30 
                 + +y s+a+t+  e++ +GsN +GQ
  EFC37391.1 450 CYSYYSIAITDKREMFLTGSNKCGQ 474
                 77899*******************9 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0   0.00036       2.2      10      88 ..     536     630 ..     528     639 .. 0.67
   2 !   36.6   0.4     7e-13   4.2e-09      11      97 ..     766     855 ..     756     869 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00036
                 TS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST..............TTTTCCCE...EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHH CS
         BTB  10 lcDvtlvvgdgkefkahkavLaarSpyFkalftsk..............eieessvs...eielddvepeafealLefiYtgeleitseenleelL 88 
                 l D  + + d+k+++    +++ar p+F+a  ++               +  ess        ++  +++++ ++L++iYt+ l+    ++++e L
  EFC37391.1 536 LLDSYIICSDDKQYPILYDFVMARFPFFEAFSKDVsgvpslerpskkrkSRGESSIRiidLSSISTLSSKSVLKILKYIYTDVLDDF-GTTIQEDL 630
                 56777777777777777777788888887766555777777776655442223333333333346667899*************995.66666655 PP

  == domain 2  score: 36.6 bits;  conditional E-value: 7e-13
                 S-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST.....TTTTCCCE.....EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-H CS
         BTB  11 cDvtlvvgdgkefkahkavLaarSpyFkalftsk.....eieessvs.....eielddvepeafealLefiYtgeleitseenleelLaaadllqip 97 
                  Dv lv+ + ++++ahka+La   ++F++ fts+     +              e d+ e +a  ++++++Yt ++ ++  +n++++L+  +++ ++
  EFC37391.1 766 GDVKLVLSKSTTIHAHKAILAVKCDFFRVKFTSGmcdmdS------FdisddSEEEDKEEVQAHISFIKYLYTNQVLLN-GSNAVSFLTKWNFYSMD 855
                 49********************************666642......22333345568899999999************7.*************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (946 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.24s 00:00:00.79 Elapsed: 00:00:00.41
# Mc/sec: 6871.06
//
Query:       EFC37392.1  [L=283]
Description: C-4 sterol methyl oxidase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.9e-28   98.1  16.6    4.9e-28   98.1  16.6    1.9  2  FA_hydroxylase  Fatty acid hydroxylase superfamily
  ------ inclusion threshold ------
       0.24   10.8   0.1       0.39   10.1   0.1    1.2  1  DUF373          Domain of unknown function (DUF373)


Domain annotation for each model (and alignments):
>> FA_hydroxylase  Fatty acid hydroxylase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.33   2.9e+03      47      66 ..      45      64 ..      19      85 .. 0.56
   2 !   98.1  16.6   5.4e-32   4.9e-28       2     133 .]     134     266 ..     133     266 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.33
  FA_hydroxylase 47 ahplealllallllllllll 66
                     +++ +++l  +l l+++l+
      EFC37392.1 45 VSLAYIFVLYGILSLPWFLI 64
                    22222233333333444443 PP

  == domain 2  score: 98.1 bits;  conditional E-value: 5.4e-32
  FA_hydroxylase   2 llallledfveYwvHrllHrvkllwrrlHkvHHsseaptalaalrahplealllallllllllllg..plsalllvlvlaallelliHsglhvsl 94 
                     l++l++ed ++Yw+Hr+lH+ ++ ++++Hk HH++++p  +++++a+  e++ll++  ++  +l+g  ++  ++++++++++ ++ +H+g  +++
      EFC37392.1 134 LIFLVIEDAYFYWIHRWLHT-EWAYKHIHKMHHEYQTPIGYCSSYASCTEFVLLGVGSFIGPFLFGipHIIGWWVWMTIRQIEAIDTHTG--FYF 225
                     6899***************6.8*********************************55555555666689999999***************..9** PP

  FA_hydroxylase  95 gwll...erllatpraHrlHHskneegnfgvllslwDrlfgT 133
                     +w +     +  +p +H++HH+ ++ gn+++++++wD+l+gT
      EFC37392.1 226 PWCMsnlIPFYSGPLHHDFHHKTYN-GNYASTFTWWDYLCGT 266
                     ***96553349**************.***************9 PP

>> DUF373  Domain of unknown function (DUF373)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.1   4.4e-05      0.39     125     174 ..      13      62 ..       9      80 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 4.4e-05
      DUF373 125 svkrVvVkqsrniEstyyllkkalkdpelrktiLvplGlllliyallll..l 174
                 +v  V  +q+ ++ ++yyl++  +++ e+  t+ v l+ ++++y++l+l  +
  EFC37392.1  13 WVGNVDLNQMDTLHQFYYLIRSNFSELEI--TTYVSLAYIFVLYGILSLpwF 62 
                 66777789*****************6555..66789***********98551 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       574  (0.0320152); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 1959.88
//
Query:       EFC37393.1  [L=332]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (332 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1701  (0.0948742); expected 358.6 (0.02)
Passed bias filter:                      539  (0.030063); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.45
# Mc/sec: 2217.24
//
Query:       EFC37394.1  [L=511]
Description: FBOX domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.4e-07   29.7   0.2    1.1e-06   28.4   0.2    1.6  1  F-box-like  F-box-like
      1e-06   28.4   0.2      1e-06   28.4   0.2    2.4  3  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.2   1.2e-10   1.1e-06       1      35 [.      35      70 ..      35      76 .. 0.89

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 1.2e-10
  F-box-like  1 isrLPdEiLlqIFsyLp.psdLlrlalVCrrWrrva 35
                + +LP Ei ++I+s+Lp +  + rl++VC++W+++ 
  EFC37394.1 35 WEDLPLEIYSEILSFLPvLPNYFRLSRVCKSWKDIF 70
                679*************84669************996 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.2   1.2e-10     1e-06       3      38 ..      35      71 ..      34      77 .. 0.94
   2 ?   -2.7   0.0       0.7   6.2e+03      17      34 ..      94     111 ..      94     114 .. 0.69
   3 ?   -2.3   0.2       0.5   4.5e+03      31      44 ..     459     472 ..     459     474 .. 0.82

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 1.2e-10
                HHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHT CS
       F-box  3 lsrLPsevlrhILerLplsd.llalrrVSkgwrilid 38
                + +LP+e+  +IL++Lp    +++l+rV+k+w+++ +
  EFC37394.1 35 WEDLPLEIYSEILSFLPVLPnYFRLSRVCKSWKDIFN 71
                89*******************************9976 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.7
                 TS-HHHHHHHCTT-HHHH CS
       F-box  17 rLplsdllalrrVSkgwr 34 
                 r++ sdll +   ++g++
  EFC37394.1  94 RMEYSDLLKIIANCRGVK 111
                 688889777666677766 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 0.5
                 HHHHHHHTTHHHHH CS
       F-box  31 kgwrilidsdrlwc 44 
                 k+w+++  + + + 
  EFC37394.1 459 KRWKNYFSKFKNDI 472
                 89****99988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (511 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       826  (0.0460706); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3012.04
//
Query:       EFC37395.1  [L=588]
Description: apoptosis inhibitory 5 family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-81  274.2  17.1    2.9e-81  273.9  17.1    1.1  1  API5           Apoptosis inhibitory protein 5 (API5)
     0.0046   17.0   2.4     0.0046   17.0   2.4    2.8  4  Cnd1           non-SMC mitotic condensation complex subunit 1
  ------ inclusion threshold ------
      0.072   13.3   0.8       0.26   11.5   0.1    2.3  2  RTP1_C1        Required for nuclear transport of RNA pol II C
       0.27   11.5   3.8       0.24   11.6   1.1    2.3  2  Ribosomal_S15  Ribosomal protein S15


Domain annotation for each model (and alignments):
>> API5  Apoptosis inhibitory protein 5 (API5)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  273.9  17.1   6.5e-85   2.9e-81       2     515 ..      26     584 ..      25     587 .. 0.80

  Alignments for each domain:
  == domain 1  score: 273.9 bits;  conditional E-value: 6.5e-85
        API5   2 ekLYenyeiLadakdki............seheeeYkeileav..kgsakeKrLasqlipkFfkfFPslaekaidaqlDLiedddlgirkqAikdLpsl 86 
                 + LY+n e L++a   +            +  +++Y+ il+ v  + s+k+K La q+ipk++  FPsl+++++ +qlDL+e++d +ir  A k+Lp+l
  EFC37395.1  26 DFLYKNEEELSNALKAAiqeqgtqvpnleASAKSHYEAILNIVspNHSKKAKELACQFIPKYAANFPSLSSESMSKQLDLCEEEDKSIRINATKGLPKL 124
                 66777777777763322111111111111345789******98335699************************************************** PP

        API5  87 ckdtkeyvskiadiLaQlLitedaveldavhkallsllkldakasltalfkqietee........etvRekvlkfireklftlkeellk..pteemeef 175
                 c +++ ++s++++iL+QlL+ ed+ve + v+++l +l+ +d+k++ ++l++ ++t          e +Rek+++fi+e +f+ ++ +    + e++e+ 
  EFC37395.1 125 CINNTVNISQVTSILTQLLKEEDPVEAKVVRQSLNELMDIDPKETFKSLLDLVATPAvqdspketELLREKTVEFISEIMFKKRKAIQAklSGEDTEKE 223
                 *****************************************************998788999999************9998876554321258999999 PP

        API5 176 ilelikkvlq..........dvtadEfkllmdlLkslki..katvegvqeLveiieeqadLdaqfnvsdkd...hvdrlisclkkalpffskgvssskf 259
                 i++ i k+l           +  a+ ++l+++l   lk+  k++ +++q L + i    dL+++++ +d++   ++ +lis l++a + + +   +  +
  EFC37395.1 224 IITVIEKILRlfasssfsnkEKEAEHMRLFLSLVARLKSyeKDSFKFMQFLRNHIP--VDLTKPLDLADEEdrwKLRKLISFLRAAKKGMVHLKDNAPY 320
                 99999999953333222111223344778999999999999999999999998774..678888777776644479*********************** PP

        API5 260 lnylnkkilpvfdklpea.....ekkldlLkllAeisaftgaqdkarellesvvelLleymplpkeeeaeeeeelqftyvEclLyafhqLakkspnfln 353
                 ++yl ++i+p++++l+++     + ++d Lk++ ei  ft+++  +r +l+ ++++L++ +p +       +++l++t +Ec+L+ fhqLa k+  +ln
  EFC37395.1 321 FSYLMNQIFPSLNNLNTSvpeedKLRVDTLKAITEIALFTSENH-SRAILPLIYQTLKNEIPEKD----AANPKLNLTNIECFLFIFHQLAFKAQGSLN 414
                 ****************9999966666788************999.*******************9....999*************************** PP

        API5 354 s...............ednseklkdfreRLqylarlvqatikklkealkekaleeakteenkakv....talkttsNiltlikdLfkkpPsf..kskvn 431
                 +                d+++  +d  +RL +l+  v  ++ +l+e++  k+l++ k+eenk+kv      l  + Nil+l++ L+k+ P f    + +
  EFC37395.1 415 EicgikiitgqptdnyGDFKQLRQDMLQRLGNLEAAVSPYVPRLEESI--KVLKAEKKEENKEKVrmetQILNCAKNILELTRALKKNRPDFisTLTTK 511
                 **************9999******************************..99************99997789999*****************8777889 PP

        API5 432 lSwkeakkksaaattaaagakrkaaitfngsesskaakkargekkqrqqyvppsgklsnkanessgkgrgsgsrgrgrg.gggrG 515
                 +Sw    kk +++++    + r       g++++++++k + + ++++  +  +   s ++++s +  +  g rgrgrg    rG
  EFC37395.1 512 PSWITYRKKVKNTKR----KDRD------GKDNNQGKNKVQKRDNNQNKNNQRRIDSSSNNRDSGS--NNRGGRGRGRGgNSNRG 584
                 ****97665544332....2222......2223333333333333332211112222222222233..33345666664233344 PP

>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.1     5e+03      94     131 ..      29      72 ..      20      89 .. 0.50
   2 !   17.0   2.4     1e-06    0.0046      21     132 ..      97     209 ..      77     255 .. 0.84
   3 ?   -1.7   0.0       0.6   2.7e+03      93     124 ..     249     275 ..     210     290 .. 0.44
   4 ?   -1.9   0.0      0.68   3.1e+03      77     106 ..     348     378 ..     315     405 .. 0.60

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.1
        Cnd1  94 ynllpdiisklsdalne......csewgqitilefLlsyipkdk 131
                 y++  ++ + l++a++e        e++ ++ +e++l+ +++++
  EFC37395.1  29 YKNEEELSNALKAAIQEqgtqvpNLEASAKSHYEAILNIVSPNH 72 
                 55555555555555444555555334444444444444443333 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 1e-06
        Cnd1  21 ylvepLrkrLkDedpyVRktaaivvakLilndmvkekgflselaklleDenprVvanalaalteiseksenaiynllpdiis.klsdalnecsewgqit 118
                 + +++    ++ ed  +R +a  ++ kL  n++v  +++ s l +ll++e+p   + ++ +l+e+ + ++++++++l d++    +++  + +e  + +
  EFC37395.1  97 ESMSKQLDLCEEEDKSIRINATKGLPKLCINNTVNISQVTSILTQLLKEEDPVEAKVVRQSLNELMDIDPKETFKSLLDLVAtPAVQDSPKETELLREK 195
                 4444445567899***************9999***************************************9*99999976514555666677777778 PP

        Cnd1 119 ilefLlsyipkdkq 132
                  +ef+++ + k+++
  EFC37395.1 196 TVEFISEIMFKKRK 209
                 88888877777766 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.6
        Cnd1  93 iynllpdiisklsdalnecsewgqitilefLl 124
                  ++l+ +++ +l+       e++  + ++fL 
  EFC37395.1 249 HMRLFLSLVARLK-----SYEKDSFKFMQFLR 275
                 2222222222222.....23333334445554 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 0.68
        Cnd1  77 nalaalteisek.senaiynllpdiisklsd 106
                  +l a+tei+   sen    +lp i++ l++
  EFC37395.1 348 DTLKAITEIALFtSENHSRAILPLIYQTLKN 378
                 3444555555554444444555555555554 PP

>> RTP1_C1  Required for nuclear transport of RNA pol II C-terminus 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   5.7e-05      0.26       8      91 ..     106     185 ..      99     206 .. 0.74
   2 ?   -3.1   0.0       1.9   8.6e+03      23      50 ..     231     258 ..     225     271 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5.7e-05
     RTP1_C1   8 lqdpllpvrahglvlLrkliekkskeavldiekilkllleaLkdedsYvYLnaikgLvaLadvfpeevlklLleeyeeenekes 91 
                 ++++   +r ++   L kl+ +++    ++i++++++l + Lk+ed+     + + L +L+d++p+e++k Ll+ +++ + + s
  EFC37395.1 106 CEEEDKSIRINATKGLPKLCINNT----VNISQVTSILTQLLKEEDPVEAKVVRQSLNELMDIDPKETFKSLLDLVATPAVQDS 185
                 555556666677777777777765....99****************9555555589******************9955444443 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.9
     RTP1_C1  23 LrkliekkskeavldiekilkllleaLk 50 
                 + +l+ ++s +++++  + ++l+l+ ++
  EFC37395.1 231 ILRLFASSSFSNKEKEAEHMRLFLSLVA 258
                 4556666666666666777777777666 PP

>> Ribosomal_S15  Ribosomal protein S15
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.81   3.6e+03      18      55 ..     220     259 ..     208     264 .. 0.71
   2 ?   11.6   1.1   5.4e-05      0.24       7      68 ..     468     529 ..     462     533 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.81
                    HHHHHHHHHHHHHHHHH..HHHCTTT-HHHHHHHHHHHHH CS
  Ribosomal_S15  18 pevqiallterInnlte..hlkenkkDkhsrrgLlklvsk 55 
                    +e  i  ++e+I +l     +++++k  ++ r  l lv++
     EFC37395.1 220 TEKEIITVIEKILRLFAssSFSNKEKEAEHMRLFLSLVAR 259
                    6778888999999886522566666777777777777766 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 5.4e-05
                    HHSSSTT-TSSHHHHHHHHHHHHHHHHHHHHCTTT-HHHHHHHHHHHHHHHHHHHHHHHH-H CS
  Ribosomal_S15   7 efqrhekDtGspevqiallterInnltehlkenkkDkhsrrgLlklvskRrkllkYLkrkdv 68 
                    e ++++k    +e qi +  ++I +lt+ lk+n+ D+ s  + +      rk +k  krkd+
     EFC37395.1 468 EKKEENKEKVRMETQILNCAKNILELTRALKKNRPDFISTLTTKPSWITYRKKVKNTKRKDR 529
                    45556668889**************************9988877666666666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (588 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1882  (0.10497); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.42
# Mc/sec: 4157.59
//
Query:       EFC37396.1  [L=409]
Description: hypothetical protein NAEGRDRAFT_81960 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.4e-10   38.7   0.1    2.5e-09   37.0   0.1    1.9  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
  ------ inclusion threshold ------
       0.22   11.4   9.7       0.35   10.7   9.7    1.3  1  PRR18        Proline-rich protein family 18
        0.5   10.7   4.9        1.5    9.2   5.0    1.9  1  FAM195       FAM195 family
        3.3    5.5  10.0        4.7    5.0  10.0    1.2  1  V_ATPase_I   V-type ATPase 116kDa subunit family
        6.8    6.5  19.3        1.4    8.7   6.7    3.5  3  DivIC        Septum formation initiator


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   0.1   6.9e-13   2.5e-09       3     119 ..     274     390 ..     272     391 .. 0.93

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 6.9e-13
                  HHHHHHCTTT.SSEEEEEEECTT.TEEEEEESS-HHHHHHHHHHTTT-EEEEEEE.EEECCSECCEEEEEEEEE--TTS-HHHHHHHHHHHHHHHHHC CS
  Cofilin_ADF   3 eafkelksgkktkyilfkidddk.eeivveeegetyeelreelpeseprYavydv.eyehddeskrsklvfIswvPdsapikqkmlyasskdalkkel 98 
                  ea+++++++ + +++ +++d+++ + ++ ++ g++++el+e+l+ +++  a+++v   e dd   r ++v +++++++++  ++  + ++ + + +  
   EFC37396.1 274 EAYQDMRQQPTVSFVSMEYDEKNaKHLKFSKNGKSLSELVEQLTPDNAVHAIVKVcALELDD-VVRDRFVAVTFIGENVRQVRRGAITANINHFIDYY 370
                  79******99***********999*******999*********8889999999994455555.*********************************** PP

                  TTSEEEEEE-CGGCCSHHHHH CS
  Cofilin_ADF  99 kgisveieatdldelteeelk 119
                   g++v+i+  d + ++ee ++
   EFC37396.1 371 -GLTVSIHLKDVSHIKEEIIE 390
                  .****************9886 PP

>> PRR18  Proline-rich protein family 18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   9.7   9.9e-05      0.35      40     108 ..     187     257 ..     153     265 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 9.9e-05
       PRR18  40 tqpqppasprvsp..qaspgrartpatcttprlaasgespaagtsagtGataaGtsaGagarpddavrfsl 108
                   p p+++ ++    +++  r+rt +t +tp++++s  s   +    + a+a+ ts+G+g+ +  +  fsl
  EFC37396.1 187 RLPSPTLEKTSGQpsTPTHNRTRTVSTFSTPQPVKSNASSIESKGEKPAAAATTTSSGNGSVNRFSRSFSL 257
                 34788877665441255667899999*************9999999999999999***9998888777776 PP

>> FAM195  FAM195 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   5.0   0.00042       1.5      42     100 ..      61     143 ..      21     146 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00042
      FAM195  42 ndsWnevvaelesdekgeaea........................stssstsvvvYkekepspslkdFkPfDLeswwgkrlln 100
                 +    ++v +le+++++++++                        +++++++v++++++++ ++l++F  f++e+++++++l+
  EFC37396.1  61 KARSLQLVSQLETECQSKQKEledlikekqelkdlvsnntqndqvDEQTAKKVQEFVNSKTVHNLEKFSSFEIENLKAEQVLR 143
                 555555555555555555444555566666666666665555443444599**************************999886 PP

>> V_ATPase_I  V-type ATPase 116kDa subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0  10.0    0.0013       4.7      41     127 ..      37     125 ..      11     162 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0013
  V_ATPase_I  41 flee.eieklekavikeeeaeesleapeekeldeleeelekleeelkelnenleklkkelnelvelkavlekakefleee.eeeeeeee 127
                 ++++ + e +++++i++e+  e l+a++ + +++le+e++++++el++l +++++lk+ +++ ++  +v e++++ ++e  ++++ ++ 
  EFC37396.1  37 LIQKkQAELKNEIQIETEKFIEGLKARSLQLVSQLETECQSKQKELEDLIKEKQELKDLVSNNTQNDQVDEQTAKKVQEFvNSKTVHNL 125
                 343303333445556666669999******************************************99998888887755333333222 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   2.8       0.1   3.6e+02      15      42 ..      24      51 ..      16      63 .. 0.77
   2 ?    8.7   6.7   0.00039       1.4      15      60 ..      64     108 ..      60     120 .. 0.80
   3 ?    2.3   0.0     0.039   1.4e+02      15      57 ..     281     322 ..     275     327 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.1
                XXXHHHHHHHHHHHHHHHHHHHHHHHHH CS
       DivIC 15 gllaykqlkqeiaalqaelaklkaenee 42
                + ++ +ql+  i+ +q++ a+lk+e++ 
  EFC37396.1 24 QTCSDQQLHVAIELIQKKQAELKNEIQI 51
                5566678888999999999999999875 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00039
                 XXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-XXXXXXXXXX CS
       DivIC  15 gllaykqlkqeiaalqaelaklkaeneeLeaevkdLksdedyieer 60 
                 +l+ ++ql+ e + +q+el+ l +e++eL++ v++ + + d ++e+
  EFC37396.1  64 SLQLVSQLETECQSKQKELEDLIKEKQELKDLVSNNT-QNDQVDEQ 108
                 5666789*****************************6.55555554 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.039
                 XXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-XXXXXXX CS
       DivIC  15 gllaykqlkqeiaalqaelaklkaeneeLeaevkdLksdedyi 57 
                 ++ +++ +  e+++++a+  k ++  ++L + v++L+  ++++
  EFC37396.1 281 QQPTVSFVSMEYDEKNAKHLKFSKNGKSLSELVEQLT-PDNAV 322
                 566777778899999*********************5.55555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2620  (0.146132); expected 358.6 (0.02)
Passed bias filter:                      627  (0.0349713); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.28s 00:00:00.98 Elapsed: 00:00:00.47
# Mc/sec: 2619.19
//
Query:       EFC37397.1  [L=1686]
Description: rhoGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-41  142.6   1.7    5.7e-41  140.7   1.7    2.1  1  RhoGEF      RhoGEF domain
  ------ inclusion threshold ------
        9.9    6.0   8.4        5.2    6.9   0.0    3.4  3  Tom22       Mitochondrial import receptor subunit Tom22


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  140.7   1.7   6.4e-45   5.7e-41       2     182 .]    1275    1453 ..    1274    1453 .. 0.94

  Alignments for each domain:
  == domain 1  score: 140.7 bits;  conditional E-value: 6.4e-45
                  HHHHHHHHHHHHHHHHHHHHHTHCCCHHCT..CCHHHHHHHHCTTHHHHHHHHHHHHHHHHHHHH.HHHTTSS-S-SHHHHHHHHSTHHHHHHHHHC CS
      RhoGEF    2 ikElleTErsYvrdLkvlvevylkplsele..vlseeeikiiFsnieeilelhrsflleeLeerlkeseeqkeaqsigdvflkfadkfkkYseYcsn 96  
                  +kE+l+TEr+Yv+++  ++e y+ pl +    ++se++ ++iF+ +  i++lh + l+++Leer+   +e+++ q+i+d+f k+ + fk Y+++ ++
  EFC37397.1 1275 AKEILDTERAYVTSMAKIIELYYYPLLKYLpnLISEDDKSKIFGGLLGIYKLH-KILVTDLEERV---NEWHKDQKIADIFIKLHQTFKLYTTFSTK 1367
                  69*********************7776544789********************.999999*****...7999999********************** PP

                  HHHHHHHHHHHHHHHHHHHHHHHHHHTSGGGTT--HHHHTTHHHHHHHHHHHHHHHHHHTS-.TTSHHHHHHHHHHHHHHHHHHHHH CS
      RhoGEF   97 ypnalkllkelskknkkfkafleeaeerpecskldLeslLikPvqRlprYpLLLkellkntp.eshpdyealkkaleaikevaseiN 182 
                  y+ a+++++++ k n++f+++l  ++++p  ++ +L+ +LikP+qR+prY+LLLk llk+t+ ++hpd+ +l +a++  +eva+ +N
  EFC37397.1 1368 YEMAIETYSKH-KDNPRFRNYLYIRRKDPFSKGEQLQGFLIKPIQRIPRYILLLKGLLKHTKnPEHPDFGNLVNAISITEEVATFLN 1453
                  **********6.5************************************************6256******************9987 PP

>> Tom22  Mitochondrial import receptor subunit Tom22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.2      0.24   2.2e+03      32      46 ..    1185    1197 ..    1167    1202 .. 0.51
   2 ?    1.4   1.4     0.027   2.5e+02      14      65 ..    1229    1278 ..    1219    1306 .. 0.46
   3 ?    6.9   0.0   0.00058       5.2      45      74 ..    1458    1486 ..    1440    1502 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.24
       Tom22   32 detdsdseissdedd 46  
                  +++dsds+++s  d+
  EFC37397.1 1185 ADSDSDSDYDS--DE 1197
                  22333333332..22 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.027
       Tom22   14 eeqegeeeelaeededeadetdsdseis.sdedddfdvedE.tlldRivALkDi 65  
                  +++++++   +e+++  +d++ +++ +s ++++d  ++e+E  +l+R    k+i
  EFC37397.1 1229 TTETSPN---IESNKT-SDNSATETKTStEKQEDVKQLENEkDILERENLAKEI 1278
                  3333333...111111.1112222222222333444444442356664444444 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.00058
       Tom22   45 dddfdvedEtlldRivALkDiippttRksi 74  
                  ++++ ++  +++dR++ L D+i p++R  i
  EFC37397.1 1458 ERQYFYRMKSVADRLSGLTDLIQPQRRY-I 1486
                  5666677889**************8774.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1686 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1540  (0.0858944); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.13u 0.35s 00:00:01.48 Elapsed: 00:00:00.57
# Mc/sec: 8983.78
//
Query:       EFC37398.1  [L=551]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0023   18.0   1.1     0.0023   18.0   1.1    5.1  6  DUF1664       Protein of unknown function (DUF1664)
     0.0035   16.3   7.0     0.0035   16.3   7.0    2.8  3  DUF812        Protein of unknown function (DUF812)
  ------ inclusion threshold ------
      0.027   15.1   2.1      0.027   15.1   2.1    5.4  5  SlyX          SlyX
       0.04   14.7   0.6       0.04   14.7   0.6    2.7  3  RraB          Regulator of ribonuclease activity B
       0.22   10.8  46.9      0.016   14.6  17.5    3.0  3  SF-assemblin  SF-assemblin/beta giardin
       0.35   11.5  10.0       0.76   10.4   0.2    4.2  5  DUF883        Bacterial protein of unknown function (DUF883)
        2.5    6.9  45.7       0.31    9.9   1.1    3.6  3  Spc7          Spc7 kinetochore protein
        3.1    7.8  44.3       0.56   10.2  10.4    4.7  5  Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C
        5.2    7.6  31.4       0.87   10.1   0.8    4.9  4  NPV_P10       Nucleopolyhedrovirus P10 protein
        5.3    6.5  40.8        3.9    7.0  33.9    3.7  2  Filament      Intermediate filament protein


Domain annotation for each model (and alignments):
>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   1.1   1.3e-06    0.0023      62     122 ..     197     257 ..     177     258 .. 0.89
   2 !    5.9   4.0    0.0069        12      43     104 ..     274     335 ..     267     350 .. 0.58
   3 ?    3.0   7.6     0.057     1e+02      37     117 ..     307     384 ..     306     405 .. 0.57
   4 !    6.5   3.3    0.0046       8.2      35      94 ..     390     454 ..     388     482 .. 0.66
   5 ?    2.0   5.1      0.11     2e+02      45     104 ..     441     502 ..     418     517 .. 0.69
   6 ?    1.0   0.5      0.22     4e+02      36      65 ..     484     513 ..     478     543 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.3e-06
     DUF1664  62 rhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeavegleskleriee 122
                  +L s+i  +d+++ +q+++ k+ + ++++++++++++++  ++v++ v + ++ le++e+
  EFC37398.1 197 ADLGSKISAIDAQVAQQEKVRKKRQMQIESIESKIDNVNTFTNKVNSRVDSTNGALEKLET 257
                 4799******************************************************995 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0069
     DUF1664  43 vesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedve 104
                  + + ++ +q+s+ +++ k+   ++ ++v k+l++ +e  + ++ ++++++++ls+ +++++
  EFC37398.1 274 TNLIEEKFNQLSSRIEQEKNARIQENESVKKRLKNLEEQVSTVHLNIESLSQELSSQSNQLH 335
                 45555566666666666666666666666666666666666666666665555555444444 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.057
     DUF1664  37 rslsdavesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeavegleskl 117
                 ++l++ v++v  ++e++s++l+++ ++L     + ++ l++ k   k++++ + + +++++    +++ vk+ ++++e  +
  EFC37398.1 307 KNLEEQVSTVHLNIESLSQELSSQSNQLHLLSTNFNSFLNQYKTERKQLADSIISESKETQ---IKFTDVKQKINNMELDV 384
                 6899999999999999999999988888776667666666666665555555443322222...22222222222222211 PP

  == domain 4  score: 6.5 bits;  conditional E-value: 0.0046
     DUF1664  35 Tkrslsda.vesvskqleqvseslaatkrh....Lssridrvdkkldeqkeiskeikeevtevre 94 
                 T  +ls+a ++++++qle++ +++ ++ r+    + s++++++++l++qk  +++  ++v+++ +
  EFC37398.1 390 TLSNLSNAhINEITTQLEKLFTEIGTQTRQstdpIWSKLEQIQNTLESQKINTAHQFNNVQQLMN 454
                 667899885699*********99987777622225567788888888777777776677766643 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.11
     DUF1664  45 svskqleqvseslaatkrh.Lssridrvdkkldeqk.eiskeikeevtevredlseigedve 104
                 + ++q ++v++ ++a+k + Ls+ i+   +kl+  + +  k+ k+++ ++r d+++ +e v+
  EFC37398.1 441 NTAHQFNNVQQLMNAQKMEiLSEFIQPTSDKLERLIiQNDKQSKKNLFDLRADIEKQQELVN 502
                 45678888888888888773566688888888875415667788888888887776555444 PP

  == domain 6  score: 1.0 bits;  conditional E-value: 0.22
     DUF1664  36 krslsdavesvskqleqvseslaatkrhLs 65 
                 k++l d  +++ kq e v +sl++ ++++ 
  EFC37398.1 484 KKNLFDLRADIEKQQELVNSSLNKLQDRIV 513
                 677777777777777777777776666554 PP

>> DUF812  Protein of unknown function (DUF812)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   7.0     2e-06    0.0035     152     381 ..      51     273 ..      26     276 .. 0.60
   2 ?   -0.8  15.9       0.3   5.4e+02     357     462 ..     278     381 ..     273     398 .. 0.75
   3 ?   -5.2  23.7       6.5   1.2e+04     181     350 ..     331     516 ..     322     544 .. 0.51

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2e-06
      DUF812 152 elqgsrkvrafrtq.pleipkaskgkskenskelkefyke.llplvtaqlssraslvpslleenaaelaaeqeweeeaneqglasrlteeeykkrk..k 246
                 + + s+++ ++rt  p + ++   ++s +  +++ + +++ +l++++  ++s++s+vp ++  +   l++ +  ++ + +++++++ ++++y+     +
  EFC37398.1  51 SSTTSSASSPLRTGiPSSQSS---SRSYNAHHNSSSGSTNgYLEPLS--PASSSSTVPQTFG-KYINLPSFSTLSSSNVSNNIKKSPNNNNYNILSshS 143
                 444555555555552222222...22333333344444555777777..7777777888777.555566666666666666665554444444443113 PP

      DUF812 247 eklqkrlaeqlrkaalkseeae.ssasksksdlaellsefseksetdslktkgsrfthaeklqftkeelakkaeteeelkkkreeeleelqeqieeles 344
                 ++  +  ++  r+a+ + +++  +s+ +++++ +e+l+  s+++e+  +k k + + ++ ++       ++++ ++e ++kkr+ ++e+++++i++++ 
  EFC37398.1 144 NNSDSPGKQFSRSALNSITNYDsRSNDSDEITEDEFLNGTSNSVEGAGSKIKFADLGSKISA------IDAQVAQQEKVRKKRQMQIESIESKIDNVNT 236
                 33333334444444444444444444455555555666665555554433333333333222......22578899*********************** PP

      DUF812 345 kieeleeeikklessikqveeeleeekeeneelekev 381
                   +++++ +++ +  ++++e +l  e+ ++e+ ek++
  EFC37398.1 237 FTNKVNSRVDSTNGALEKLETQLFHERGNRERGEKNI 273
                 **************************99999999986 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.3
      DUF812 357 essikqveeeleeekeeneelekevklkkktlell.pdaeeniekLqalveasaqrlvelakqWekhRvplieeyrelkesksekekeaerkleeikkl 454
                 e++ +q+++ +e+ek+ + +++++vk++ k le    +   nie L +++ +++++l  l++ +++   +   e ++l +s+ +  ke++ k +++k+ 
  EFC37398.1 278 EEKFNQLSSRIEQEKNARIQENESVKKRLKNLEEQvSTVHLNIESLSQELSSQSNQLHLLSTNFNSFLNQYKTERKQLADSIISESKETQIKFTDVKQ- 375
                 67788899999988888888777777777766664477999999999999999999999999999888888888888888888888888888777764. PP

      DUF812 455 rekmkeva 462
                   k+ +++
  EFC37398.1 376 --KINNME 381
                 ..333333 PP

  == domain 3  score: -5.2 bits;  conditional E-value: 6.5
      DUF812 181 skelkefykellplvtaqlssraslvpslleenaaelaaeqeweeeaneqglasrlteeeykkrkkeklqkrlaeqlrkaalkseeaessasksksdla 279
                 s++l+ +++++  ++++   +r++l+ s+++e +++  + ++++++ n+ +l+ + ++    ++ ++   ++++ ql+k +++  +   ++ +s++++ 
  EFC37398.1 331 SNQLHLLSTNFNSFLNQYKTERKQLADSIISESKETQIKFTDVKQKINNMELDVQ-KQISTLSNLSNAHINEITTQLEKLFTEIGT---QTRQSTDPIW 425
                 3444445555666677777778888888888888888888888888888888433.233333333444445566666666555443...3345566666 PP

      DUF812 280 ellsefseksetdslktkgsrfthaeklqftke.....................ela.kkaeteeelkkkreeeleelqeqieeleskieele 350
                 ++l+++++  e+ ++ + + +f++ ++l  +++                     + + +++++  +l++  e++ e +++ +++l+ +i + e
  EFC37398.1 426 SKLEQIQNTLES-QKINTAHQFNNVQQLMNAQKmeilsefiqptsdklerliiqN-DkQSKKNLFDLRADIEKQQELVNSSLNKLQDRIVSEE 516
                 666666333333.334445555555555333333333334444444444333321.1234444444444444444444555554444444333 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.5     0.024        42      12      52 ..     196     236 ..     193     251 .. 0.72
   2 ?   -1.8   0.0       2.8   5.1e+03       5      14 ..     252     261 ..     248     276 .. 0.85
   3 ?   15.1   2.1   1.5e-05     0.027       2      55 ..     303     356 ..     302     367 .. 0.87
   4 ?    0.0   1.5      0.75   1.3e+03       3      41 ..     375     414 ..     373     442 .. 0.72
   5 ?    0.2   1.2      0.66   1.2e+03       8      54 ..     458     504 ..     454     519 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.024
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXX CS
        SlyX  12 lafqedtieeLndvvaeqqqqidrlqrqlrllaerlkelee 52 
                  a +   i + +++va+q++  ++ q q++ ++ ++ ++++
  EFC37398.1 196 FADLGSKISAIDAQVAQQEKVRKKRQMQIESIESKIDNVNT 236
                 55555667778888888888888888888888887766655 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2.8
                 HHHHHHHHHH CS
        SlyX   5 leeLEiklaf 14 
                 le+LE++l +
  EFC37398.1 252 LEKLETQLFH 261
                 7899999877 PP

  == domain 3  score: 15.1 bits;  conditional E-value: 1.5e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXX CS
        SlyX   2 eerleeLEiklafqedtieeLndvvaeqqqqidrlqrqlrllaerlkeleessg 55 
                 ++rl++LE++++     ie+L++++  q  q+  l + ++   ++ k+ +++ +
  EFC37398.1 303 KKRLKNLEEQVSTVHLNIESLSQELSSQSNQLHLLSTNFNSFLNQYKTERKQLA 356
                 58***********************************99999999877666655 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.75
                 HHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHH CS
        SlyX   3 erleeLEiklafqedtieeLndv.vaeqqqqidrlqrqlr 41 
                 ++++++E  +  q  t+  L+++ + e   q+++l +++ 
  EFC37398.1 375 QKINNMELDVQKQISTLSNLSNAhINEITTQLEKLFTEIG 414
                 7788888888888888888865525566666666655554 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.66
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXX CS
        SlyX   8 LEiklafqedtieeLndvvaeqqqqidrlqrqlrllaerlkeleess 54 
                 +Ei   f + t ++L + +++ ++q ++    lr+  e+ +el +ss
  EFC37398.1 458 MEILSEFIQPTSDKLERLIIQNDKQSKKNLFDLRADIEKQQELVNSS 504
                 67777788888888888888888888887777777777777766654 PP

>> RraB  Regulator of ribonuclease activity B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1       5.8     1e+04      62      62 ..     312     312 ..     270     342 .. 0.50
   2 ?   14.7   0.6   2.2e-05      0.04      31      94 ..     351     414 ..     347     418 .. 0.92
   3 ?   -0.3   0.3      0.99   1.8e+03      54      86 ..     478     512 ..     430     518 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 5.8
        RraB  62 e 62 
                 +
  EFC37398.1 312 Q 312
                 2 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 2.2e-05
        RraB  31 edeedlekfaeeleklgyevedaeedeedgeevycldlskemsldaeeIdaiteeleelaekfg 94 
                 e+++ +++++ e ++ +++++d +++ ++ e +++ ++s+ + l++++I++it++le+l ++ g
  EFC37398.1 351 ERKQLADSIISESKETQIKFTDVKQKINNMELDVQKQISTLSNLSNAHINEITTQLEKLFTEIG 414
                 67889999*******************9999****************************99877 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.99
        RraB  54 eedeedge....evycldlskemsldaeeIdaiteel 86 
                 ++d++  +     +  +d++k+++l ++++++++ ++
  EFC37398.1 478 QNDKQ--SkknlFDLRADIEKQQELVNSSLNKLQDRI 512
                 33332..122347788889999999999998888765 PP

>> SF-assemblin  SF-assemblin/beta giardin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6  17.5   8.8e-06     0.016      88     199 ..     211     321 ..     192     340 .. 0.64
   2 ?   -2.6  20.0       1.5   2.7e+03       5     172 ..     304     478 ..     299     488 .. 0.73
   3 ?    1.9  19.9     0.065   1.2e+02       2     168 ..     365     543 ..     364     550 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 8.8e-06
  SF-assemblin  88 lelkkaveelnekinnveanvenekakrrdaieklakelvkelneleaaideEkaerkkkedqlnkkveEdlkklsakidtEkniRdsevsaltaev 184
                   ++ +k  ++   +i  +e+++ n      ++++ + ++  + l +le+++ +E+ +r + e+++++ +eE++ +ls +i++Ekn+R +e + ++  +
    EFC37398.1 211 AQQEKVRKKRQMQIESIESKIDNVNT-FTNKVNSRVDSTNGALEKLETQLFHERGNRERGEKNITNLIEEKFNQLSSRIEQEKNARIQENESVKKRL 306
                   44444444445566666666665544.3445666666777777777777777777777777777777777777777777777777777777776666 PP

  SF-assemblin 185 eeiklekklaneqlk 199
                   ++   +  ++  +++
    EFC37398.1 307 KNLEEQVSTVHLNIE 321
                   666655555555544 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.5
  SF-assemblin   5 vKlerltervegfekelenEieqkrvdektrvklikeaiakleksveaEvkkRaes......dkdiq.eefkkeikklqekikeevddlalelkkav 94 
                    +l++l e+v+ ++ ++e    q    ++++++l+    +    + ++E k+ a+s      + +i+   +k++i+++ + +++++ +l    +  +
    EFC37398.1 304 KRLKNLEEQVSTVHLNIESLS-QELSSQSNQLHLLSTNFNSFLNQYKTERKQLADSiiseskETQIKfTDVKQKINNMELDVQKQISTLSNLSNAHI 399
                   468999999999999988654.455667888999999999998889999888765433221234555445788899999999999998876666668 PP

  SF-assemblin  95 eelnekinnveanvenekakrrdaieklakelvkelneleaaideE.kaerkkkedqlnkkveEdlkklsakidtEkni 172
                   +e+  ++  + + +  +  +  d i  + +++ + l   + + ++  ++ ++ ++ q ++ + E ++  s k+++  + 
    EFC37398.1 400 NEITTQLEKLFTEIGTQTRQSTDPIWSKLEQIQNTLESQKINTAHQfNNVQQLMNAQKMEILSEFIQPTSDKLERLIIQ 478
                   9999999999999999999999999888888888887776665544145555678888888889888888888875555 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.065
  SF-assemblin   2 etavKlerltervegfekelenEieqkrvdektrvklikeaiakleksveaEvkkRae....sdkdiqeefkkeikklqekikeevddlale....l 90 
                   et++K   + ++++ +e ++++ i    +  + +++ i   ++kl  ++ +  ++  +    + ++iq+ ++++  +   + +++ + + ++    l
    EFC37398.1 365 ETQIKFTDVKQKINNMELDVQKQISTLSNLSNAHINEITTQLEKLFTEIGTQTRQSTDpiwsKLEQIQNTLESQKINTAHQFNNVQQLMNAQkmeiL 461
                   89*************************************************99998753332679******99877766655555444444310112 PP

  SF-assemblin  91 kkaveelnekinnveanvenekakr......rdaieklakelvkelneleaaideEkaerkkkedqlnkkveEdlkklsakidt 168
                    + ++   +k+  +   ++n+k+++      r +iek+++ +  +ln+l+  i  E+  r + e +l   +   + ++++ i+ 
    EFC37398.1 462 SEFIQPTSDKLERL--IIQNDKQSKknlfdlRADIEKQQELVNSSLNKLQDRIVSEEKVRGEGEANLLALLSKTMSRIKKTIES 543
                   33445555555544..46888777622222256999999999999**************************9999999999986 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.2      0.97   1.7e+03      34      47 ..     300     313 ..     267     335 .. 0.46
   2 ?   -0.3   0.1      0.92   1.7e+03      18      46 ..     359     387 ..     320     393 .. 0.54
   3 ?    0.5   0.1      0.54   9.7e+02      16      60 ..     357     401 ..     343     408 .. 0.68
   4 ?    3.7   0.0     0.051        92       5      50 ..     397     442 ..     393     457 .. 0.76
   5 ?   10.4   0.2   0.00042      0.76       8      56 ..     466     514 ..     458     521 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.97
      DUF883  34 erleerlerarerl 47 
                 e +++rl+++ e++
  EFC37398.1 300 ESVKKRLKNLEEQV 313
                 22233333333333 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.92
      DUF883  18 lkeaadeageeaeelRerleerlerarer 46 
                 + + ++e++ +  +++++++++  +++++
  EFC37398.1 359 IISESKETQIKFTDVKQKINNMELDVQKQ 387
                 23334444444445555554444444444 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.54
      DUF883  16 ellkeaadeageeaeelRerleerlerarerlrdaeeavaerake 60 
                 + + + ++e++ +  +++++++++  +++++++ +++   ++++e
  EFC37398.1 357 DSIISESKETQIKFTDVKQKINNMELDVQKQISTLSNLSNAHINE 401
                 444566777888888888888888888888887776655555555 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.051
      DUF883   5 aeleslladleellkeaadeageeaeelRerleerlerarerlrda 50 
                 a +++++++le+l+ e + +++++++ + ++le+  +++ ++  ++
  EFC37398.1 397 AHINEITTQLEKLFTEIGTQTRQSTDPIWSKLEQIQNTLESQKINT 442
                 678999****************999999888777655555544444 PP

  == domain 5  score: 10.4 bits;  conditional E-value: 0.00042
      DUF883   8 eslladleellkeaadeageeaeelRerleerlerarerlrdaeeavae 56 
                 +   ++le l+ +  +++++++ +lR+ +e++ e + ++l++++++++ 
  EFC37398.1 466 QPTSDKLERLIIQNDKQSKKNLFDLRADIEKQQELVNSSLNKLQDRIVS 514
                 667899**************************************99775 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   1.1   0.00017      0.31     200     259 ..     195     254 ..     158     262 .. 0.86
   2 ?    9.6  17.0    0.0002      0.37     167     274 ..     272     376 ..     265     395 .. 0.81
   3 ?   -4.8  15.9       5.2   9.4e+03     150     282 ..     376     501 ..     367     516 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00017
        Spc7 200 eLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeaervlee 259
                 + + l +++++++a++++++k  +++q q+e++e+ki+++++  +++++++ + +  le+
  EFC37398.1 195 KFADLGSKISAIDAQVAQQEKVRKKRQMQIESIESKIDNVNTFTNKVNSRVDSTNGALEK 254
                 56677789999*******************************999999999998888876 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0002
        Spc7 167 ellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeaervleeckgwse 265
                 ++ + +ee++++l++++e++++a+ + +++ k++L++l e++++++ +ie++++el++  +ql  l++++++  +q+++ ++++a +     ++ +++ 
  EFC37398.1 272 NITNLIEEKFNQLSSRIEQEKNARIQENESVKKRLKNLEEQVSTVHLNIESLSQELSSQSNQLHLLSTNFNSFLNQYKTERKQLADSIISESKETQIKF 370
                 6777899***************888888888***************************************99999999999988865555555555556 PP

        Spc7 266 sevsrlkee 274
                 ++v++   +
  EFC37398.1 371 TDVKQ---K 376
                 66544...3 PP

  == domain 3  score: -4.8 bits;  conditional E-value: 5.2
        Spc7 150 gleedkelLekqeeeldellpe.leeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelq..eqleeleekieelkeqkse 245
                 ++++ +  ++kq + l++l ++ ++e  ++le+ ++++ ++ ++ ++    +Le+++++l+++k + +++ +++++l   +++e l+e i+ ++++   
  EFC37398.1 376 KINNMELDVQKQISTLSNLSNAhINEITTQLEKLFTEIGTQTRQSTDPIWSKLEQIQNTLESQKINTAHQFNNVQQLMnaQKMEILSEFIQPTSDKL-- 472
                 4444455566666666666554144455577777777777777766777899999999999999999977777777641133444444444433333.. PP

        Spc7 246 leeeiaeaervleeckgwsesevsrlkeevkaleelt 282
                         er++ ++ + s++++  l++  ++ +el 
  EFC37398.1 473 --------ERLIIQNDKQSKKNLFDLRADIEKQQELV 501
                 ........33333444444444444444444444444 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   3.6     0.012        21      20      80 ..     201     256 ..     185     286 .. 0.51
   2 ?    3.0   7.6     0.055        99      40     108 ..     274     345 ..     270     347 .. 0.54
   3 ?    5.6  14.2    0.0087        16      36     123 ..     302     399 ..     288     401 .. 0.73
   4 ?   10.2  10.4   0.00031      0.56      16      98 ..     368     450 ..     362     457 .. 0.88
   5 ?    1.1   5.3      0.21   3.7e+02      18      84 ..     446     513 ..     439     543 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.012
  Baculo_PEP_C  20 nvLnairlqnvqilaqlatlldaietqLnalsedlksllaeldtrldtlltnLtdalnalq 80 
                     ++ai    +q+ aq ++  ++ + q++++++++ + ++ +++++++ ++  + al +l+
    EFC37398.1 201 SKISAI---DAQV-AQQEKVRKKRQMQIESIESKIDN-VNTFTNKVNSRVDSTNGALEKLE 256
                   333333...3333.33344444444444444444443.33333333333333333333333 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.055
  Baculo_PEP_C  40 ldaietqLnalsedlksll.aeldt..rldtlltnLtdalnalq...dtlrneLtnlnsiltnLlssvtNinstL 108
                    + ie+++n+ls+++++   a +++   +++ l+nL++++ ++    ++l++eL +  ++l  L    tN ns L
    EFC37398.1 274 TNLIEEKFNQLSSRIEQEKnARIQEneSVKKRLKNLEEQVSTVHlniESLSQELSSQSNQLHLLS---TNFNSFL 345
                   44455555555555544320222224467777777777777766667777777776666666555...5555555 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0087
  Baculo_PEP_C  36 latlldaietqLnalsedlksllaeldt..........rldtlltnLtdalnalqdtlrneLtnlnsiltnLlssvtNinstLnnllqalnnldlga 122
                   +++ l+++e+q++++  +++sl++el++          +++++l++ ++  ++l+d++ +e + ++ + t+   ++ N++  ++  +++l nl +  
    EFC37398.1 302 VKKRLKNLEEQVSTVHLNIESLSQELSSqsnqlhllstNFNSFLNQYKTERKQLADSIISESKETQIKFTDVKQKINNMELDVQKQISTLSNLSNAH 398
                   5566667777777777777777777766666666677788888888888888888888888888888888888888888888888888888876655 PP

  Baculo_PEP_C 123 l 123
                   +
    EFC37398.1 399 I 399
                   5 PP

  == domain 4  score: 10.2 bits;  conditional E-value: 0.00031
  Baculo_PEP_C  16 ldLtnvLnairlqnvqilaqlatlldaietqLnalsedlksllaeldtrldtlltnLtdalnalqdtlrneLtnlnsiltnLl 98 
                   + +t+v + i + +  +  q++tl +  +  +n+++++l++l +e+ t+  ++++ + ++l ++q+tl+++  n+  + +n +
    EFC37398.1 368 IKFTDVKQKINNMELDVQKQISTLSNLSNAHINEITTQLEKLFTEIGTQTRQSTDPIWSKLEQIQNTLESQKINTAHQFNNVQ 450
                   5678888899999999*************************************************999998888888888765 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.21
  Baculo_PEP_C  18 LtnvLnairlqnvqilaq.latlldaietqLnalsedlksllaeldtrldtlltnLtdalnalqdtlr 84 
                   ++nv + + +q+++il++ ++ + d++e+ + + +++ k+ l +l+++++++ + ++++ln+lqd + 
    EFC37398.1 446 FNNVQQLMNAQKMEILSEfIQPTSDKLERLIIQNDKQSKKNLFDLRADIEKQQELVNSSLNKLQDRIV 513
                   45555555566667666535556677777777777777777777777888888888888888886664 PP

>> NPV_P10  Nucleopolyhedrovirus P10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.9    0.0012       2.1      16      63 ..     199     250 ..     194     262 .. 0.69
   2 ?   10.1   0.8   0.00049      0.87      15      59 ..     301     342 ..     294     351 .. 0.86
   3 ?    1.7   9.4       0.2   3.5e+02      15      67 ..     372     437 ..     357     455 .. 0.73
   4 ?   -0.9   1.2       1.3   2.4e+03      33      52 ..     486     502 ..     441     545 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0012
     NPV_P10  16 vddkVdalqqqv...ddvqenlp.dvtelnekLdaqsaqLaeletkvenIqd 63 
                 + +k++a+++qv   ++v+++ + +++ +++k+d+ ++  +++++ v++ + 
  EFC37398.1 199 LGSKISAIDAQVaqqEKVRKKRQmQIESIESKIDNVNTFTNKVNSRVDSTNG 250
                 5577777777775544455543326788888888888888888888876554 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00049
     NPV_P10  15 avddkVdalqqqvddvqenlpdvtelnekLdaqsaqLaeletkve 59 
                  v+++++ l++qv  v+ n++    l+++L +qs+qL+ l+t+ +
  EFC37398.1 301 SVKKRLKNLEEQVSTVHLNIES---LSQELSSQSNQLHLLSTNFN 342
                 68899999******99998877...99***********9998654 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.2
     NPV_P10  15 avddkVdalqqqvddvqenlpdvtel.nekLdaqsaqLaelet...............kvenIqdiLnp 67 
                 +v++k++ ++     vq+++ ++++l n++++++++qL++l t               k+e+Iq++L +
  EFC37398.1 372 DVKQKINNMELD---VQKQISTLSNLsNAHINEITTQLEKLFTeigtqtrqstdpiwsKLEQIQNTLES 437
                 344444444444...444455555553678999999999999989999999999*999******99984 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 1.3
     NPV_P10  33 nlpdvtelnekLdaqsaqLa 52 
                 nl d   l + +++q++ ++
  EFC37398.1 486 NLFD---LRADIEKQQELVN 502
                 3333...3333333333332 PP

>> Filament  Intermediate filament protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0  33.9    0.0022       3.9      29     291 ..     198     455 ..     195     463 .. 0.65
   2 ?   -0.7   0.7      0.46   8.3e+02      70      92 ..     491     513 ..     459     543 .. 0.49

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0022
                 XXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament  29 eLeakieeleekksaevsklkelyekeleelrkqldeltkerarlqleldnlreeledlrkkyekelnkreevEaelkalrkdldeatlarvdLekkve 127
                 +L +ki++   +  a+++k+++  + ++e++ +++d++++  ++++  +d+++ +le+l +++ +e ++re  E+++ +l  +  ++  +r++ ek   
  EFC37398.1 198 DLGSKISAIDAQ-VAQQEKVRKKRQMQIESIESKIDNVNTFTNKVNSRVDSTNGALEKLETQLFHERGNRERGEKNITNLIEEKFNQLSSRIEQEKNAR 295
                 678899999888.77788899999********************************************************9999999999999887654 PP

                 XX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-HHHHHHHHHHH CS
    Filament 128 sL.keelaflkkvheeEvkelqkqvseqvlvevdaarkldLteilkeiraqyeelaeknreeaeewykskleelqeaaeknsealrsakeeitelrrqi 225
                    +e ++ + k+ ee v++++ ++ e+++ e+ +++++     l+ + +++++  +++++e ++        + +++++ + +   +k+ i+++   +
  EFC37398.1 296 IQeNESVKKRLKNLEEQVSTVHLNI-ESLSQELSSQSNQ-----LHLLSTNFNSFLNQYKTERKQLAD----SIISESKETQIKFTDVKQKINNMELDV 384
                 3213445555567777777777777.5555555443332.....333333444444444433333322....222222222233333333333333333 PP

                 HHHHHHHHHH.....HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament 226 qsleielesl.....kkqkasleaqlaeleerleaeleklqeklseleeelaeireemarqlreYqeLLdv 291
                 q+  + l++l      +   +le+  +e+  +  +  + + +kl+++++ l++ + ++a q+++ q+L++ 
  EFC37398.1 385 QKQISTLSNLsnahiNEITTQLEKLFTEIGTQTRQSTDPIWSKLEQIQNTLESQKINTAHQFNNVQQLMNA 455
                 33333333330000033345567777777777777778888888888888888888888888888888874 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.46
                 XXXXXXXXXXXXXXXXXXXXXXX CS
    Filament  70 rarlqleldnlreeledlrkkye 92 
                 ra ++ +++ ++ +l++l+ ++ 
  EFC37398.1 491 RADIEKQQELVNSSLNKLQDRIV 513
                 22222222222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (551 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2846  (0.158737); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                        37  (0.0020637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.21u 0.38s 00:00:01.59 Elapsed: 00:00:00.57
# Mc/sec: 2935.24
//
Query:       EFC37399.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00098   19.0   0.3     0.0095   15.9   0.0    2.5  2  Y_Y_Y     Y_Y_Y domain
     0.0046   15.8   1.1        0.1   11.4   0.7    2.8  3  REJ       REJ domain
  ------ inclusion threshold ------
      0.039   14.1   3.1        0.5   10.6   0.1    2.8  2  Big_3_5   Bacterial Ig-like domain (group 3)
       0.78   10.0   3.2         18    5.6   0.5    3.2  3  He_PIG    Putative Ig domain


Domain annotation for each model (and alignments):
>> Y_Y_Y  Y_Y_Y domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   2.1e-06    0.0095      24      63 ..     220     259 ..     210     260 .. 0.83
   2 ?    0.2   0.0      0.17   7.6e+02      38      49 ..     338     349 ..     328     365 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 2.1e-06
                 ESSTS.EEEEES--SEEEEEEEEEEETTS-B-SS-EEEEE CS
       Y_Y_Y  24 asdysqeasytnlppGdYtlkVkakdndgqwnyditslsf 63 
                 ++d+s +   +nl  G Yt++V+++++++++ + +ts+++
  EFC37399.1 220 ITDSSITMRVSNLDIGVYTVQVSVRNSKSESASATTSFEI 259
                 4555449999****************99999998888776 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.17
                 SEEEEEEEEEEE CS
       Y_Y_Y  38 pGdYtlkVkakd 49 
                 +G+Y++k+ +  
  EFC37399.1 338 EGEYVFKLTVQE 349
                 699999987655 PP

>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0     0.097   4.3e+02     234     264 ..     142     180 ..     134     194 .. 0.83
   2 !   11.4   0.7   2.3e-05       0.1     152     209 ..     215     271 ..     193     279 .. 0.81
   3 ?    0.2   0.0     0.055   2.5e+02      47      79 ..     338     362 ..     305     370 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.097
         REJ 234 kd.lkdvtfeW.......slsqtseeysllpdkatsslt 264
                 ++ ++ vt++W       ++s+t +  + l+dka ssl 
  EFC37399.1 142 SSiVEIVTVKWgkrknelTVSLTADRSHILKDKARSSLL 180
                 44478899************************9999875 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 2.3e-05
         REJ 152 gtllssstssltfpaselvanltynftltvskrsrksasteqtilvvdgepplvsiec 209
                  +l + + ss+t+  s+l  ++ y++++ v+ ++ +sas++    + dg  p+vsi+ 
  EFC37399.1 215 ASLSTITDSSITMRVSNLDIGV-YTVQVSVRNSKSESASATTSFEIIDGAAPIVSIQN 271
                 5566788999999999999995.99999999999999999999999999999999976 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.055
         REJ  47 sfLpygtyvflltvslsgepsleatdiikvrve 79 
                 +    g+yvf+ltv+ +g p      +++ +v 
  EFC37399.1 338 E----GEYVFKLTVQEEGVP----DGSVTFKVT 362
                 3....677777777766666....344444444 PP

>> Big_3_5  Bacterial Ig-like domain (group 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.4     0.024   1.1e+02      41      77 ..     218     253 ..     188     264 .. 0.76
   2 ?   10.6   0.1   0.00011       0.5       7      40 ..     338     369 ..     332     373 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.024
                 EE--TTSEEEEEEE-SS-EEEEEEEEEE-TTS---S- CS
     Big_3_5  41 vllsanGtAtltvsalaaGthsitAtYsGdanyaast 77 
                 ++++ + + t+ vs+l  G ++++++   +++ +as+
  EFC37399.1 218 STIT-DSSITMRVSNLDIGVYTVQVSVRNSKSESASA 253
                 3344.68999999999999999998866555544444 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00011
                 TSEEEEEEE--CCCCTTS--EEEEEETTEE-SS- CS
     Big_3_5   7 gqtvtltatVtaasggtptGtVtftdggttlgta 40 
                 + ++ ++ tV++   g+p G+Vtf++++t+l+  
  EFC37399.1 338 EGEYVFKLTVQEE--GVPDGSVTFKVTATSLAKR 369
                 5567788888888..9*************99865 PP

>> He_PIG  Putative Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.04   1.8e+02      35      47 ..     231     246 ..     188     248 .. 0.71
   2 ?    0.8   0.0      0.13   5.8e+02      34      46 ..     337     349 ..     328     352 .. 0.79
   3 ?    5.6   0.5     0.004        18      32      46 ..     351     365 ..     345     368 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.04
      He_PIG  35 p...GsytftVtatdg 47 
                     G+yt+ V++ ++
  EFC37399.1 231 NldiGVYTVQVSVRNS 246
                 15559*******9876 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.13
      He_PIG  34 apGsytftVtatd 46 
                 + G+y f +t+  
  EFC37399.1 337 TEGEYVFKLTVQE 349
                 459*******975 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.004
      He_PIG  32 tvapGsytftVtatd 46 
                 +v  Gs tf Vtat+
  EFC37399.1 351 GVPDGSVTFKVTATS 365
                 5677**********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       638  (0.0355848); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 2223.60
//
Query:       EFC37400.1  [L=222]
Description: alpha/beta hydrolase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.5e-08   32.4   0.0    7.2e-08   32.0   0.0    1.1  1  Hydrolase_4    Serine aminopeptidase, S33
    4.5e-07   29.7   0.1    6.3e-07   29.2   0.1    1.1  1  LIDHydrolase   Lipid-droplet associated hydrolase
    3.3e-05   24.6   0.0      4e-05   24.3   0.0    1.1  1  Abhydrolase_6  Alpha/beta hydrolase family
     0.0033   17.1   0.1     0.0065   16.2   0.1    1.6  1  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.083   12.8   0.2       0.13   12.1   0.2    1.4  1  Lipase_3       Lipase (class 3)


Domain annotation for each model (and alignments):
>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.0   0.0     2e-11   7.2e-08      16     121 ..      71     188 ..      60     207 .. 0.77

  Alignments for each domain:
  == domain 1  score: 32.0 bits;  conditional E-value: 2e-11
  Hydrolase_4  16 hsgryaelaeaLaaq..GfavyalDhrGhGrse....gkrghvpsfddyvdDlaafvekvkeehpel......plfllGhSmGGliallyllrypdkv 101
                  h   y  +a+ La q  ++ v+++D+rG G+s     +   +  s+ d+ +D+  ++e+vke h++       +l+++GhS G+++ ++   +  + v
   EFC37400.1  71 HQTFYLSFAKFLAGQseNVIVFTYDYRGMGKSRntekP-IQKDVSYLDFAKDFWGMLEHVKEYHSQHastcemELTVVGHSIGAYLLMTCPPHLGKLV 167
                  788899999999976337889************65432.222336778999999999****999888888999*************999887777777 PP

  Hydrolase_4 102 aglilsaPalkikaklk.app 121
                  +++ l+++  ++  + + ++ 
   EFC37400.1 168 NRAFLASSYHAYFGYSSpFRN 188
                  788888777666555444555 PP

>> LIDHydrolase  Lipid-droplet associated hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.2   0.1   1.7e-10   6.3e-07      16     102 ..      73     159 ..      59     173 .. 0.89

  Alignments for each domain:
  == domain 1  score: 29.2 bits;  conditional E-value: 1.7e-10
  LIDHydrolase  16 eFYetFlsllseklnpelevlgishaGfeleeee.keakenekvfsLedQiehkedflkellekaksekdvklilvGHSvGaYialev 102
                   +FY  F++ l+ + + ++ v ++ ++G+ ++++  k +++  ++ ++ +      + +ke+ ++++s+ +++l +vGHS+GaY+ +  
    EFC37400.1  73 TFYLSFAKFLAGQ-SENVIVFTYDYRGMGKSRNTeKPIQKDVSYLDFAKDFWGMLEHVKEYHSQHASTCEMELTVVGHSIGAYLLMTC 159
                   7************.99************98887757888889999999999999*******99999******************9875 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   0.0   1.1e-08     4e-05      10      95 ..      71     174 ..      62     211 .. 0.58

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 1.1e-08
                    ....GCHHHHHHHHCCT...CEEEEE--TTST......S-GGCS--HHH.CHHHHHHHCCTT...............TTSE..EEEEETCHHHHHH CS
  Abhydrolase_6  10 sassWlvapLaallaag...vhvlapDlpGhG......rsdpppldled.ladlaalldelaa.............gggpv..vlvGHSlGGalal 80 
                    +++ +l  ++a++la++   v v+++D++G+G       +  ++ ++ d + d+        +             ++++    +vGHS G++l +
     EFC37400.1  71 HQTFYL--SFAKFLAGQsenVIVFTYDYRGMGksrnteKPIQKDVSYLDfAKDF-------WGmlehvkeyhsqhaSTCEMelTVVGHSIGAYLLM 157
                    455566..666777777777888*********5543332233333332222222.......2222222224434332222255**********999 PP

                    HHHHCC....EEEEES- CS
  Abhydrolase_6  81 aaapla..lvvgvlldp 95 
                       p++  lv + +l++
     EFC37400.1 158 TCPPHLgkLVNRAFLAS 174
                    95555565333344444 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.1   1.8e-06    0.0065      32     107 ..      91     183 ..      62     200 .. 0.71

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 1.8e-06
                    EEEEEETTSTTSSSTTTGB..........CHH.SHHHHHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHHHGGGEEEEEEESE.......C CS
  Abhydrolase_1  32 villDlrGvgySspapacin.........ddy.gtasvaddldrildalgddkltlvGhSmGGmialayaaeyperVkalvllga.......i 107
                    v+++D rG g+S+    +i+         +d+ g+  + + ++   +++   +lt+vGhS G  + ++      + V++  l ++       +
     EFC37400.1  91 VFTYDYRGMGKSRNTEKPIQkdvsyldfaKDFwGMLEHVKEYHSQHASTCEMELTVVGHSIGAYLLMTCPPHLGKLVNRAFLASSyhayfgyS 183
                    899*****************554443333222355555555555577777789*********9999888777777777777777765554443 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.2   3.7e-05      0.13      51      77 ..     125     154 ..      68     169 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.7e-05
                 HHHHHHHHHHHTT...-EEEEEEEETHHHH CS
    Lipase_3  51 vlkelkrllekyp...eysivvtGHSLGga 77 
                 +l+ +k+  +++    e++++v+GHS+G+ 
  EFC37400.1 125 MLEHVKEYHSQHAstcEMELTVVGHSIGAY 154
                 67788888888888889***********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.34s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1269.84
//
Query:       EFC37401.1  [L=176]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       353  (0.0196888); expected 358.6 (0.02)
Passed bias filter:                      293  (0.0163422); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1098.59
//
Query:       EFC37402.1  [L=196]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       891  (0.049696); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.26s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1249.83
//
Query:       EFC37403.1  [L=152]
Description: ubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.7e-62  207.1   6.3    8.4e-31  105.5   0.6    2.0  2  ubiquitin    Ubiquitin family
    8.1e-30  102.5   8.3    1.4e-14   53.7   0.8    2.0  2  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
      1e-08   34.9   0.4     0.0019   18.1   0.1    2.2  2  TBK1_ULD     TANK binding kinase 1 ubiquitin-like domain
    1.3e-08   35.2   3.8     0.0024   18.3   0.5    3.0  2  Ubiquitin_2  Ubiquitin-like domain
    1.8e-08   34.4   0.4     0.0013   18.8   0.1    2.8  2  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
    3.3e-07   30.6   2.3      0.013   15.8   0.2    2.1  2  Ubiquitin_5  Ubiquitin-like domain
    7.9e-07   29.6   0.1     0.0094   16.5   0.0    2.1  2  DUF2407      DUF2407 ubiquitin-like domain
    6.9e-05   22.8   7.5        2.6    8.2   0.2    4.0  4  Ubiquitin_4  Ubiquitin-like domain
  ------ inclusion threshold ------
       0.02   15.3   1.3       0.84   10.0   0.2    2.7  3  bPH_3        Bacterial PH domain
      0.048   13.8   0.6       0.84    9.8   0.1    2.3  2  DUF3861      Domain of Unknown Function with PDB structure (D
      0.052   13.4   0.3        3.3    7.6   0.1    2.2  2  Coagulin     Coagulin
       0.11   12.2   0.0          7    6.4   0.0    2.3  2  Raf1_HTH     Rubisco accumulation factor 1 helix turn helix d
       0.13   12.4   1.4         17    5.6   0.2    2.2  2  ProRS-C_2    Prolyl-tRNA synthetase, C-terminal
       0.22   11.7   1.6          2    8.6   0.3    2.6  3  PI3K_rbd     PI3-kinase family, ras-binding domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  105.5   0.6   6.6e-34   8.4e-31       1      72 []       3      74 ..       3      74 .. 0.99
   2 !  105.1   0.7   9.4e-34   1.2e-30       1      72 []      79     150 ..      79     150 .. 0.99

  Alignments for each domain:
  == domain 1  score: 105.5 bits;  conditional E-value: 6.6e-34
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                ++vktl+g++itleve++d++e++K k+++kegi ++qqrLi++Gk+Led rt+ +y+iq++stlhlvlrlr
  EFC37403.1  3 LFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQLEDGRTINDYNIQKDSTLHLVLRLR 74
                79*******************************************************************986 PP

  == domain 2  score: 105.1 bits;  conditional E-value: 9.4e-34
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 ++vktl+gk+it+e+e++dtve+ K+ki +kegip +qqrLiy+Gk+Led rt+ +y++q++st+hlvlrlr
  EFC37403.1  79 LFVKTLTGKTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQLEDGRTINDYNLQKDSTVHLVLRLR 150
                 79*******************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.7   0.8   1.1e-17   1.4e-14       1      72 []       1      71 [.       1      71 [. 0.98
   2 !   53.3   1.4   1.4e-17   1.8e-14       1      72 []      77     147 ..      77     147 .. 0.98

  Alignments for each domain:
  == domain 1  score: 53.7 bits;  conditional E-value: 1.1e-17
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                +++++k+ +g +++++V+++  +++++++ ++k+gi++ +++rLiF G++L++  t++d+ i++++t+++v+
  EFC37403.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDKEGISP-DQQRLIFAGKQLEDGRTINDYNIQKDSTLHLVL 71
                79************************************.******************************986 PP

  == domain 2  score: 53.3 bits;  conditional E-value: 1.4e-17
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 +++++k+ +gk+++i+ +++ tv++++++  +k+gip  +++rLi+ G++L++  t++d+ +++++t+++v+
  EFC37403.1  77 MQLFVKTLTGKTITIEMESNDTVENMKQKIFDKEGIPS-DQQRLIYAGKQLEDGRTINDYNLQKDSTVHLVL 147
                 79************************************.******************************996 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   1.1e-05     0.015      19      55 ..      17      51 ..       9      72 .. 0.83
   2 !   18.1   0.1   1.5e-06    0.0019      15      52 ..      89     126 ..      80     144 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.1e-05
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrllle 55
                +++++ ++++  +v+++  i++++Q l+f g++l  e
  EFC37403.1 17 VESNDSIENVKRKVQDKEGISPDQQRLIFAGKQL--E 51
                6789999*************************87..3 PP

  == domain 2  score: 18.1 bits;  conditional E-value: 1.5e-06
    TBK1_ULD  15 hkiYihpyntvaifqeevakqTkiaaekQellfeghrl 52 
                 ++i +++++tv+++ ++++++  i++++Q l++ g++l
  EFC37403.1  89 ITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQL 126
                 66778999****************************97 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.2   8.2e-06      0.01      18      79 ..      15      68 ..       3      71 .. 0.79
   2 !   18.3   0.5   1.8e-06    0.0024      14      79 ..      87     144 ..      77     146 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 8.2e-06
                 EEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2 18 rrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79
                   ++++++ie++K+k++   G+sp+++rL +          k  +d ++ ++Y+++  +++h
   EFC37403.1 15 LEVESNDSIENVKRKVQDKEGISPDQQRLIFA--------GKQLEDGRTINDYNIQKDSTLH 68
                 5678899**********************997........4445677777777777777776 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 1.8e-06
                  SEEEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEE CS
  Ubiquitin_2  14 vsserrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrih 79 
                  +  ++ +++++t+e++K+k+    G++ +++rL +          k  +d ++ ++Y+++  +++h
   EFC37403.1  87 KTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYA--------GKQLEDGRTINDYNLQKDSTVH 144
                  567788999************************997........4445677777777777777777 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   7.5e-05     0.096      18      87 ..      15      71 ..       2      75 .. 0.72
   2 !   18.8   0.1   9.9e-07    0.0013      11      87 ..      85     147 ..      77     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.5e-05
                 EEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2 18 vkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87
                 ++ +++++++++k+kv      dke    s+++ +li aGk Le+ +t+++++++        +++H+v+
   EFC37403.1 15 LEVESNDSIENVKRKVQ-----DKEG--ISPDQQRLIFAGKQLEDGRTINDYNIQKD------STLHLVL 71
                 56677777777777774.....4444..567778****************9965433......3466665 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 9.9e-07
                  TS-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  11 dGsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                   G+ +  +++++++tv+++k+k++++     e  p++    +li+aGk Le+ +t+++++l+         ++H+v+
   EFC37403.1  85 TGK-TITIEMESNDTVENMKQKIFDK-----EGIPSDQ--QRLIYAGKQLEDGRTINDYNLQKDS------TVHLVL 147
                  577.77789999************74.....4455544..48****************9655433......466665 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.2   1.9e-05     0.025      34      93 ..      13      73 ..       5      78 .. 0.83
   2 !   15.8   0.2     1e-05     0.013      33      93 ..      88     149 ..      78     151 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.9e-05
  Ubiquitin_5 34 klletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93
                  +le++ + + +++ +k+ ++ g+  ++ +li  gk+le ++t+++ +++++s + +vL+l
   EFC37403.1 13 ITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQLEDGRTINDYNIQKDSTLhLVLRL 73
                 5677777778889999999999***************************999875467765 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 1e-05
  Ubiquitin_5  33 kklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                    ++e++ + t++++ +ki ++ g+  ++ +li+ gk+le ++t+++ +++++s v +vL+l
   EFC37403.1  88 TITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQLEDGRTINDYNLQKDSTVhLVLRL 149
                  55677777778999*************************************99998567765 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.0   0.00023       0.3      15      63 ..      14      58 ..       7      86 .. 0.82
   2 !   16.5   0.0   7.4e-06    0.0094      16      63 ..      89     134 ..      68     147 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00023
     DUF2407 15 eLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslas 63
                +L+++  ++ +++++k+ + ++    ++  + rLI+aG+ Led  ++++
  EFC37403.1 14 TLEVE--SNDSIENVKRKVQDKE--GISPDQQRLIFAGKQLEDGRTIND 58
                56666..5667888999999887..88999999**********998875 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 7.4e-06
     DUF2407  16 LdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslas 63 
                 ++i+  ++ tv+++kq i ++    + s + rLIyaG+ Led  ++++
  EFC37403.1  89 ITIEMESNDTVENMKQKIFDKE--GIPSDQQRLIYAGKQLEDGRTIND 134
                 678888899**********997..88888889**********999876 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.2    0.0047       6.1       1      33 [.       1      33 [.       1      42 [. 0.91
   2 !    6.5   0.1    0.0066       8.5      58      86 ..      43      70 ..      39      73 .. 0.84
   3 !    8.2   0.2     0.002       2.6       1      31 [.      77     107 ..      77     119 .. 0.90
   4 ?    4.1   0.0     0.038        49      58      86 ..     119     146 ..     115     149 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0047
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaierk 33
                 +++ vk l g+++ ++v++n +++++k+ ++ k
   EFC37403.1  1 MQLFVKTLTGRTITLEVESNDSIENVKRKVQDK 33
                 78999************************9976 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0066
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L+f g++L+ d  ++++y i+++s+l+ v
   EFC37403.1 43 LIFAGKQLE-DGRTINDYNIQKDSTLHLV 70
                 889999986.6789************976 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.002
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkaie 31 
                  +++ vk l g+++ +++++n tv+++k+ i 
   EFC37403.1  77 MQLFVKTLTGKTITIEMESNDTVENMKQKIF 107
                  78999**********************9885 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.038
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L++ g++L+ d  ++++y ++++s+++ v
   EFC37403.1 119 LIYAGKQLE-DGRTINDYNLQKDSTVHLV 146
                  889999986.6789**********99876 PP

>> bPH_3  Bacterial PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       1.9   2.5e+03      71      91 ..       7      28 ..       3      32 .. 0.58
   2 ?   10.0   0.2   0.00065      0.84      29      93 ..      40     106 ..      36     108 .. 0.90
   3 ?    2.8   0.0      0.12   1.5e+02      29      56 ..     116     143 ..     114     149 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.9
       bPH_3 71 t.sgktitidnidksevrkive 91
                t  g tit++  ++++++++ +
  EFC37403.1  7 TlTGRTITLEVESNDSIENVKR 28
                4456666666666666666555 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00065
       bPH_3  29 nkRiifldpkmfggkdfeeipYksIksvdlkkgl.lgakitlet.sgktitidnidksevrkiveai 93 
                 ++R+if  ++   g++++++  ++ +  +l  +l  g ++ ++t  gktiti++ ++++v+++ + i
  EFC37403.1  40 QQRLIFAGKQLEDGRTINDYNIQKDSTLHLVLRLrGGMQLFVKTlTGKTITIEMESNDTVENMKQKI 106
                 58********9999999**99999999999999977778999999********99*****9997765 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.12
       bPH_3  29 nkRiifldpkmfggkdfeeipYksIksv 56 
                 ++R+i+  ++   g++++++ +++ + v
  EFC37403.1 116 QQRLIYAGKQLEDGRTINDYNLQKDSTV 143
                 58********9999******99985555 PP

>> DUF3861  Domain of Unknown Function with PDB structure (DUF3861)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   0.00066      0.84      19      60 ..       9      50 ..       5      84 .. 0.90
   2 ?    2.2   0.1      0.16     2e+02      19      59 ..      85     125 ..      78     128 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00066
     DUF3861 19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglkL 60
                + +++++e+e+ d i ++ +++++ke++++d+++ +  g +L
  EFC37403.1  9 TGRTITLEVESNDSIENVKRKVQDKEGISPDQQRLIFAGKQL 50
                5579**************************999877777665 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.16
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d + ++ +++ +ke++ +d+++ +  g +
  EFC37403.1  85 TGKTITIEMESNDTVENMKQKIFDKEGIPSDQQRLIYAGKQ 125
                 557999********999999999999999998877666655 PP

>> Coagulin  Coagulin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.1    0.0026       3.3      12      44 ..       7      39 ..       5      64 .. 0.86
   2 ?    4.2   0.0     0.028        36      12      43 ..      83     114 ..      80     141 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0026
    Coagulin 12 tllgrkvivsteikdkiekaveavadkdevsgr 44
                tl gr+  +  e +d ie+  + v dk+++s  
  EFC37403.1  7 TLTGRTITLEVESNDSIENVKRKVQDKEGISPD 39
                789***************************964 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.028
    Coagulin  12 tllgrkvivsteikdkiekaveavadkdevsg 43 
                 tl g++  +  e +d +e+  + + dk+++  
  EFC37403.1  83 TLTGKTITIEMESNDTVENMKQKIFDKEGIPS 114
                 788999**********************9954 PP

>> Raf1_HTH  Rubisco accumulation factor 1 helix turn helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.05        64      35      55 ..      29      49 ..      26      52 .. 0.86
   2 ?    6.4   0.0    0.0054         7      33      55 ..     103     125 ..     101     128 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.05
    Raf1_HTH 35 eIfEaTGiepvqQnqliVaaq 55
                ++ ++ Gi+p qQ ++  + q
  EFC37403.1 29 KVQDKEGISPDQQRLIFAGKQ 49
                678999********9998877 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0054
    Raf1_HTH  33 pqeIfEaTGiepvqQnqliVaaq 55 
                  q+If++ Gi   qQ ++  + q
  EFC37403.1 103 KQKIFDKEGIPSDQQRLIYAGKQ 125
                 599************99988877 PP

>> ProRS-C_2  Prolyl-tRNA synthetase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.2     0.014        17       6      26 ..      16      36 ..      12      37 .. 0.85
   2 ?    5.6   0.1     0.014        18       6      26 ..      92     112 ..      88     117 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.014
                S--....HHHHHHHCTTT-SE CS
   ProRS-C_2  6 aenvnlllenikeklsekkGv 26
                ++++n   en+k k+++k G+
  EFC37403.1 16 EVESNDSIENVKRKVQDKEGI 36
                5678999***********998 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.014
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n  +en+k+k+ +k G+
  EFC37403.1  92 EMESNDTVENMKQKIFDKEGI 112
                 567899************997 PP

>> PI3K_rbd  PI3-kinase family, ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.24   3.1e+02      28      50 ..      10      32 ..       2      43 .. 0.80
   2 ?    8.6   0.3    0.0015         2      27      52 ..      85     112 ..      67     140 .. 0.82
   3 ?   -2.3   0.0       3.8   4.8e+03      91     103 ..     136     148 ..     131     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.24
                SEEEEEEEETTS-HHHHHHHHHH CS
    PI3K_rbd 28 qqkvtlkvnpnstpesllaealr 50
                  ++tl+v+ n++ e+++ ++  
  EFC37403.1 10 GRTITLEVESNDSIENVKRKVQD 32
                5689*********9999887655 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0015
                 -SEEEEEEEETTS-HHHHHHHHHHC..H CS
    PI3K_rbd  27 kqqkvtlkvnpnstpesllaealrk..k 52 
                 + +++t++++ n+t+e+++++++ k   
  EFC37403.1  85 TGKTITIEMESNDTVENMKQKIFDKegI 112
                 5689*******************99542 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 3.8
                 HHHCT--EEEEEE CS
    PI3K_rbd  91 clksgrephLvLv 103
                  l++++++hLvL+
  EFC37403.1 136 NLQKDSTVHLVLR 148
                 4677888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       673  (0.037537); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.51u 0.25s 00:00:00.76 Elapsed: 00:00:00.43
# Mc/sec: 1054.44
//
Query:       EFC37404.1  [L=751]
Description: abc transporter G family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-46  158.2  21.8    1.8e-46  158.2  21.8    1.5  1  ABC2_membrane    ABC-2 type transporter
    1.1e-28  100.4   0.1    1.1e-28  100.4   0.1    2.6  3  ABC_tran         ABC transporter
    1.3e-06   28.4   0.0     0.0088   15.9   0.0    2.5  2  AAA_21           AAA domain, putative AbiEii toxin, Type IV T
      3e-06   26.6  25.6      3e-06   26.6  25.6    3.1  2  ABC2_membrane_3  ABC-2 family transporter protein
    1.9e-05   24.6   0.5    0.00017   21.5   0.0    2.3  2  RsgA_GTPase      RsgA GTPase
     0.0015   19.0   0.0     0.0036   17.7   0.0    1.7  1  AAA_16           AAA ATPase domain
     0.0074   16.7   0.1       0.11   13.0   0.1    2.6  1  AAA              ATPase family associated with various cellul
     0.0083   15.9   0.0      0.082   12.6   0.0    2.3  2  IstB_IS21        IstB-like ATP binding protein
  ------ inclusion threshold ------
      0.014   15.6   0.1      0.083   13.2   0.0    2.2  2  AAA_22           AAA domain
      0.034   13.0   0.0      0.063   12.1   0.0    1.4  1  AAA_35           AAA-like domain
      0.041   13.8   0.3       0.13   12.2   0.3    1.9  1  PDR_CDR          CDR ABC transporter
      0.057   13.8   0.6       0.22   11.9   0.0    2.2  2  RNA_helicase     RNA helicase
      0.064   13.3   0.2        0.2   11.8   0.2    1.8  1  MMR_HSR1         50S ribosome-binding GTPase
      0.099   11.9   0.0      0.099   11.9   0.0    1.8  1  KAP_NTPase       KAP family P-loop domain
        0.1   12.8   0.1       0.21   11.8   0.1    1.5  1  AAA_28           AAA domain
       0.16   12.5   0.6       0.69   10.5   0.0    2.2  2  AAA_18           AAA domain


Domain annotation for each model (and alignments):
>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.2  21.8   1.6e-49   1.8e-46       1     210 []     473     685 ..     473     685 .. 0.97

  Alignments for each domain:
  == domain 1  score: 158.2 bits;  conditional E-value: 1.6e-49
  ABC2_membrane   1 tqikallkreflqrwrdpslgllwrliqplllalvfgtvfgnlg.nsedglnrpgllffsvlflafsaltsvapvfe.rergvlerelvsplysls 94 
                    tq+++++ r f +++rd+ l+ ++rl+q l +a+++g++f ++g +++++++r g+lff +++ ++++++++ +vf   e++v+ re+ s++y++s
     EFC37404.1 473 TQFFVVMARAFVNILRDKILT-FSRLFQNLAMAILVGLIFLQIGyDQQSVQDRNGVLFFCLVNQSMNSIFGSLTVFLlEEKKVFLRERGSKMYKVS 567
                    69*******************.**********************9999999****************99999888762567899************ PP

  ABC2_membrane  95 ayvlakvlvelpvsllqalifllivyflvgldls..rfflflllllltalaasslgllisalapsfedasqlaslvllpllllsGffipidsmpkw 188
                    ay+l++ ++elp ++++ ++f +ivy++ +l++   rff fll+l+ +alaa +lg+++++ aps+e a+ +a+++l++l+l++G ++++d++p +
     EFC37404.1 568 AYYLGRSISELPNIIFFPILFGTIVYWMCNLNPGadRFFVFLLILVSMALAAQALGMVLAVCAPSMEFATAIAPVLLTVLMLFGGLYMNVDNIPPY 663
                    *********************************************************************************************77* PP

  ABC2_membrane 189 lqwiaylnPltyavealrsnlf 210
                    ++wi++l+ +  ++eal+ n+f
     EFC37404.1 664 FIWIYWLSIFHFGYEALVLNEF 685
                    *****************99987 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.8       0.2   2.2e+02      46      87 ..      38      94 ..      21     183 .. 0.70
   2 !  100.4   0.1     1e-31   1.1e-28       1     137 []     184     334 ..     184     334 .. 0.97
   3 ?   -3.0   0.0       8.5   9.6e+03      79      96 ..     426     450 ..     405     467 .. 0.66

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.2
                TCEGGGB-HHHCCHCEEEE-SS--S-TTSB.HHHH...................HHHTCHHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx...................xxxxxxxx RF
    ABC_tran 46 gkdlkeqeleslrkeigvlpqepqlfpelt.vren...................esdeeiek 87
                +++++++e ++ +++ + + +++  +++++   +n                         ++
  EFC37404.1 38 QQPTQQEESQQQQQQTSLVAEDEAQNNTSSsSSSNttneenvpssnnhtntdnnV-----QN 94
                4667778888888888888888444444432333355555566554444222220.....22 PP

  == domain 2  score: 100.4 bits;  conditional E-value: 1e-31
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH................HHHT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................xxxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren................esde 83 
                 l+++s  +++g+++ai+G++GaGK++Ll++la+ +k t+G+i+++g ++++    s+r+ +++++q++ l  +l+vre+                e+ e
  EFC37404.1 184 LHEMSGFVSPGSTLAIMGPSGAGKTSLLNILAQRVKETSGDITVNGVKISS----SFRSLSAFVQQDDVLMGNLSVRETlryaallrlpktiswkEKME 278
                 56788889*****************************************99....**************************************999999 PP

                 CHHHHHHHSTTGGTTCBGESTTS..GGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  84 eiekalsklglkelkdtvvkssp..ssLSgGqkqrvalarallkkpkllllDEpta 137
                 ++e ++++lgl + ++t+v++ +  + +SgG+++r+++a  ll++p++l+lDEpt+
  EFC37404.1 279 RVESIMDELGLLKSANTKVGTPGltKGISGGERKRLSIAIELLTQPSILFLDEPTS 334
                 9******************998899*****************************96 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 8.5
                 H.......HHHTCHHHHHHHSTTGG CS
                 x.......xxxxxxxxxxxxxxxxx RF
    ABC_tran  79 n.......esdeeiekalsklglke 96 
                         e++e+iek+l++++ +e
  EFC37404.1 426 GegkklkqEDNERIEKILTNYNHTE 450
                 0334444477778888888877666 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0   0.00049      0.55       3      53 ..     198     242 ..     197     287 .. 0.65
   2 !   15.9   0.0   7.8e-06    0.0088     238     299 ..     307     365 ..     301     367 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00049
      AAA_21   3 vliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldlyd 53 
                 ++ Gp g+GK++LL +l      ++ v+ +  + + +g  ++ ++++ +  
  EFC37404.1 198 AIMGPSGAGKTSLLNIL------AQRVKETSGDITVNGVKISSSFRSLSAF 242
                 578**************......5555555555555555555555555544 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 7.8e-06
      AAA_21 238 SdGtkrllalltallralkkgsllliDEpEngLHPkllrrllellkelsrngaQviltTHSp 299
                 S G ++ l ++  ll ++   s+l++DEp +gL+ +   ++++ + + s++g  vilt H+p
  EFC37404.1 307 SGGERKRLSIAIELLTQP---SILFLDEPTSGLDAATAYSVMKTIIKISKGGRAVILTIHQP 365
                 556666666666677666...*********************888777777******98887 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   1.7      0.25   2.7e+02      29      78 ..      48      96 ..       5     224 .. 0.67
   2 !   26.6  25.6   2.7e-09     3e-06     163     343 ..     528     738 ..     409     740 .. 0.71

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.25
  ABC2_membrane_3 29 dentpiavvdedn..sslsqqlvealeaspsve..lvyevdseeeakkalkngd 78
                     ++++++ +v ed          ++  ++s++++  +v + ++ ++  + ++n +
       EFC37404.1 48 QQQQQTSLVAEDEaqN-----NTSSSSSSNTTNeeNVPSSNNHTNTDNNVQNVQ 96
                     3333333333332110.....111111111111111112222222222222222 PP

  == domain 2  score: 26.6 bits;  conditional E-value: 2.7e-09
  ABC2_membrane_3 163 lvgliliilifitasfiavsiveEkesrikelqlvsgvsplqywlskilgdflvyllqlllilll...afglgipfg..nlglllllfllfgla 251
                      l++ ++  ++  ++ +++v+++eEk+  ++e+   +  ++++y+l++ ++ + + +++ +l+  +   +++  ++ g   ++++ll ++ ++la
       EFC37404.1 528 LFFCLVNQSMNSIFGSLTVFLLEEKKVFLRERGSKM-YKVSAYYLGRSISELPNIIFFPILFGTIvywMCN--LNPGadRFFVFLLILVSMALA 618
                      333333333444455567799***********9999.****************999998888765468999..999996777777999999*** PP

  ABC2_membrane_3 252 yialgyllsslfknsetaqilifivilllsgffgglfpledlpsalkwifsiiPffapglgllrli.tgdplwe.................... 324
                      + alg++l +   ++e a +++++++ +l++f g+ + ++++p ++ wi +++ +f++g+  l l+ +g   +e                    
       EFC37404.1 619 AQALGMVLAVCAPSMEFATAIAPVLLTVLMLFGGLYMNVDNIPPYFIWI-YWLSIFHFGYEALVLNeFGGATFEcppspsactyrtgedvisrn 711
                      *******************9888888877776666677*****988865.67777888888778888444444466666666666666666667 PP

  ABC2_membrane_3 325 ........illsliilalfavvyllla 343
                              i+ +l++l++f++vy  +a
       EFC37404.1 712 amnkpysnIWFNLGLLWAFFLVYRFMA 738
                      77777777***************7776 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.0   1.5e-07   0.00017      84     130 ..     178     225 ..     142     232 .. 0.76
   2 ?    0.5   0.1      0.46   5.1e+02      31      64 ..     435     468 ..     430     508 .. 0.76

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 1.5e-07
                  TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT-----S-- CS
  RsgA_GTPase  84 aktkegleelkellkd.ktsvlvGqSGvGKStLinallpelelktgev 130
                  +k+k  l+e++  ++  +t +++G+SG+GK++L+n l+++ +   g++
   EFC37404.1 178 KKEKVILHEMSGFVSPgSTLAIMGPSGAGKTSLLNILAQRVKETSGDI 225
                  34445556677666666999******************9987777766 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.46
                  -HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHHH CS
  RsgA_GTPase  31 slnlldrfLvlaeekgiepvivlnKiDlleeeee 64 
                  ++++++++L+ ++++++ p +   K+D+ + + +
   EFC37404.1 435 DNERIEKILTNYNHTEVAPSVDHLKTDIKKAKYN 468
                  5688999999999999999999999999887763 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   3.2e-06    0.0036      22      74 ..     194     244 ..     180     331 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 3.2e-06
      AAA_16  22 grpelvllsGesGvGKsslvrellralekd......ggiflrgkcdqlesaipysalaq 74 
                 g  + + + G+sG GK+sl++ l+++++++      +g+ ++  +++l      sa++q
  EFC37404.1 194 G--STLAIMGPSGAGKTSLLNILAQRVKETsgditvNGVKISSSFRSL------SAFVQ 244
                 3..6799*****************999998554433233344444444......44444 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.1   9.4e-05      0.11       3      38 ..     199     272 ..     197     360 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 9.4e-05
                 EESSTTSSHHHHHHHHHHHHT..HEEEEEETTTCSSS....................................S CS
         AAA   3 lyGppGtGKTllakavakelg..vefleisgsellsk....................................y 38 
                 ++Gp G GKT+l + +a+ ++  +  ++++g ++ s+                                     
  EFC37404.1 199 IMGPSGAGKTSLLNILAQRVKetSGDITVNGVKISSSfrslsafvqqddvlmgnlsvretlryaallrlpktiS 272
                 78*****************9743223555555555444445555555666666666666666666666666662 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   7.3e-05     0.082      19      73 ..     165     220 ..     158     255 .. 0.73
   2 ?   -0.1   0.0       0.6   6.7e+02      98     158 ..     313     373 ..     308     380 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 7.3e-05
   IstB_IS21  19 ledidfraarsldkrkvkeL.atlsfiekkenivllGpsGvGKshlaialgveavr 73 
                 +++i f+ +++ +k++   L     f++    ++++GpsG+GK+ l   l+++  +
  EFC37404.1 165 PQKIGFKLKNMFKKKEKVILhEMSGFVSPGSTLAIMGPSGAGKTSLLNILAQRVKE 220
                 5667788887777777777724456********************99988886554 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.6
   IstB_IS21  98 klaralkrllkvdllilDdlgllpldqaeael.lfeviekryerrsiiitsnlpfaewdevl 158
                 +l+ a++ l+++++l lD+     ld a a   +  +i+   + r++i+t  +p ++  e++
  EFC37404.1 313 RLSIAIELLTQPSILFLDEPT-SGLDAATAYSvMKTIIKISKGGRAVILTIHQPRSNIYELF 373
                 6677888899999*****975.56666666550556888889999*****999988877766 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       2.4   2.7e+03      80     103 ..      42      64 ..      10      86 .. 0.71
   2 ?   13.2   0.0   7.4e-05     0.083       6      32 ..     195     221 ..     191     267 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2.4
      AAA_22  80 ealeqalraravielliiDEaqhl 103
                 ++ e + +++++ +l+  DEaq+ 
  EFC37404.1  42 QQEESQQQQQQT-SLVAEDEAQNN 64 
                 444444444445.99999999984 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 7.4e-05
      AAA_22   6 gilvvtGesGtGKTtllrrlleqldee 32 
                 + l+++G+sG+GKT ll+ l+++ +e 
  EFC37404.1 195 STLAIMGPSGAGKTSLLNILAQRVKET 221
                 5689**************999998543 PP

>> AAA_35  AAA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   5.6e-05     0.063      28      59 ..     191     222 ..     174     258 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.6e-05
      AAA_35  28 ekpGalirikapkkmGKtSLlarilakakqqg 59 
                   pG+++ i +p+  GKtSLl+ + +++k+++
  EFC37404.1 191 VSPGSTLAIMGPSGAGKTSLLNILAQRVKETS 222
                 689******************97777766653 PP

>> PDR_CDR  CDR ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.3   0.00012      0.13      42      72 ..     716     747 ..     700     751 .] 0.74

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00012
     PDR_CDR  42 ssshlwrnfgiliaflifflal.yllatelis 72 
                  +s++w n+g l+af++++ ++ yl+++ +++
  EFC37404.1 716 PYSNIWFNLGLLWAFFLVYRFMaYLILVFVVK 747
                 589**************997661555544444 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.5         3   3.3e+03      39      68 ..      41      71 ..      30     102 .. 0.68
   2 ?   11.9   0.0   0.00019      0.22       3      34 ..     199     230 ..     197     281 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 3
  RNA_helicase 39 peddfwdgYtgqevvvidDfgqvkdee.nps 68
                  ++++  ++ ++q+ +v +D +q+++++ + s
    EFC37404.1 41 TQQEESQQQQQQTSLVAEDEAQNNTSSsSSS 71
                  4455555667899999999999887754444 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00019
  RNA_helicase   3 lyGpsgeGKStlakeLakallkklklkkkdsv 34 
                   + Gpsg GK++l + La+++ +++++++ + v
    EFC37404.1 199 IMGPSGAGKTSLLNILAQRVKETSGDITVNGV 230
                   89*******************99977776655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   0.00018       0.2       2      26 ..     197     221 ..     196     233 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00018
                 EEEEESTTSSHHHHHHHHHTSTEEE CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaiv 26 
                  ai+G + +GK++L+n l +++ ++
  EFC37404.1 197 LAIMGPSGAGKTSLLNILAQRVKET 221
                 69****************9986554 PP

>> KAP_NTPase  KAP family P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   8.8e-05     0.099      18      49 ..     192     239 ..     173     490 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 8.8e-05
  KAP_NTPase  18 atpivvgLygkWGsGKssllnkledelkefa................k 49 
                 ++++++++ g+ G+GK+slln l +  ke +                 
  EFC37404.1 192 SPGSTLAIMGPSGAGKTSLLNILAQRVKETSgditvngvkisssfrsL 239
                 899*************************99666666555544444440 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   0.00019      0.21       3      22 ..     198     217 ..     196     230 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00019
      AAA_28   3 vitGgestGKTtlleaLaar 22 
                 +i+G++++GKT+ll+ La+r
  EFC37404.1 198 AIMGPSGAGKTSLLNILAQR 217
                 79****************98 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.3       2.2   2.5e+03      27      70 ..      56     109 ..      42     136 .. 0.68
   2 ?   10.5   0.0   0.00061      0.69       2      23 ..     198     220 ..     197     267 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 2.2
      AAA_18  27 nlrdvakenglllevdpealdeskrldedkldklldaleenss...........a 70 
                 +  d a++n ++ +  +  ++e+++   +++ +  +++++  s           +
  EFC37404.1  56 VAEDEAQNNTSSSSSSNT-TNEENVPSSNNHTNTDNNVQNVQStsvntkkeqeiD 109
                 566778888777777777.888888888888888777777666555544445551 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00061
      AAA_18   2 lltGtpGvGKttlakeLskrl.g 23 
                 +++G++G+GKt+l + L++r  +
  EFC37404.1 198 AIMGPSGAGKTSLLNILAQRVkE 220
                 599**************999622 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (751 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2464  (0.137431); expected 358.6 (0.02)
Passed bias filter:                      961  (0.0536003); expected 358.6 (0.02)
Passed Vit filter:                       233  (0.0129957); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 1.12u 0.38s 00:00:01.50 Elapsed: 00:00:00.57
# Mc/sec: 3958.20
//
Query:       EFC37405.1  [L=403]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.3e-30  105.0   4.4    9.8e-30  103.8   4.4    1.6  1  Pkinase      Protein kinase domain
    7.2e-30  104.1   0.9    5.9e-29  101.1   0.1    2.0  2  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.8   4.4   1.1e-33   9.8e-30       4     260 ..      79     393 ..      76     395 .. 0.85

  Alignments for each domain:
  == domain 1  score: 103.8 bits;  conditional E-value: 1.1e-33
                 EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHS...CTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHH.HHSS- CS
     Pkinase   4 leklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk...hpnivrlyevfee..kdelylvleyveggeladlle.rkgsl 95 
                 + k+ +G+f++V+k+     + i+A K++ k++ + +++ +k+++E+  ++++    ++++++l++++ +  ++++++v+e+++ g+l ++++ ++++l
  EFC37405.1  79 IDKIASGGFAEVFKIQ--IHSTIYAGKRMLKSRSQIQRNvDKFANELVKMNRIFqlgCSRVLKLVGYCFDkeNQNYWIVTEFINVGDLYSIIHcKEQTL 175
                 57899*********99..6899*******999988888889*****98888765477*********99775589999****************866667 PP

                 -HH......................HHH.HHHHHHHHHHHHHHHTT.EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS....BCTTTSCGGGS-H CS
     Pkinase  96 see......................eak.kiakqilegleylHskg.iiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtseYlAP 166
                 +++                      ++k k+a  i++ ++ lHs     H D+K+ NiL+de+ +++++D+  ak +++s +      +  gt +++AP
  EFC37405.1 176 KSHhyglerirneysklielihndmNVKiKLALDIAKCIDELHSLTrYAHLDVKSLNILVDENLQIRVGDWCDAKLVDESREhyltPFQPHGTIYWMAP 274
                 7767999999999**********99555599************76549*******************************999998888899******** PP

                 HHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS..........................-HHHH CS
     Pkinase 167 EvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasei..........................seeak 238
                 E++k+n + +k+D+++l +++ ell    p++g +  + v+++l++   i +  + +++ +++ +++i                           ++++
  EFC37405.1 275 EIVKQNVFCQKSDIYALSIVFTELLILGKPYPGLNVLD-VKEKLER-PIISNPANnNNTDNTNSDNQInntdnipyrmniieileqkgcditnqCRNFI 371
                 ********************************777766.4444444.122222223333444444444777888******************9999*** PP

                 HHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 239 dllkkllkkdpkkRltaeellq 260
                 +l+++++k+d ++Rl+ +++++
  EFC37405.1 372 SLIEDMWKEDVSERLSSKQVVE 393
                 ******************9986 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.1   0.1   6.6e-33   5.9e-29       3     220 ..      78     319 ..      76     336 .. 0.86
   2 ?    1.8   0.1     0.014   1.2e+02     230     259 .]     366     395 ..     343     395 .. 0.82

  Alignments for each domain:
  == domain 1  score: 101.1 bits;  conditional E-value: 6.6e-33
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS...-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl...khpnivkllgvct..keepllivteyvkgGdLlkfLrkk 95 
                  + +k+++G f++V++ +++  ++    k ++K+   ++ +++ +++ +e+  m+++      +++kl+g c   ++++++ivte+++ GdL + ++ k
   EFC37405.1  78 IIDKIASGGFAEVFKIQIH--STIYAGKRMLKSR--SQIQRNVDKFANELVKMNRIfqlGCSRVLKLVGYCFdkENQNYWIVTEFINVGDLYSIIHCK 171
                  57899**************..3333333334443..333445799***99999876533689**********767777******************99 PP

                  ......................CTTTSBHHHHHHHHHHHHHHHHHHHHTT.EEEST-SGGGEEEEETTEEEE-STTTHEET.TTSSEEEETTSSTSGG CS
  Pkinase_Tyr  96 ......................ekekltlkdllsfalqvAkGmeyLeskk.lvHrdlaarNvLlsenkvvkisDfGLardi.ekddeyvkkeeaklpv 169
                                        e  + +++ ++++al++Ak ++ L+s + + H d+ + N+L++en +++++D   a+ + e++++y +  + +  +
   EFC37405.1 172 eqtlkshhyglerirneyskliELIHNDMNVKIKLALDIAKCIDELHSLTrYAHLDVKSLNILVDENLQIRVGDWCDAKLVdESREHYLTPFQPHGTI 269
                  9******************9998888899999***************9644*************************9999966678889999999*** PP

                  GGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHT CS
  Pkinase_Tyr 170 kWmapEslkekkftsksDvWsfGvllwEiftlgespypglkneevleklke 220
                   WmapE++k+++f +ksD+++ +++  E++ lg +pypgl+  +v ekl++
   EFC37405.1 270 YWMAPEIVKQNVFCQKSDIYALSIVFTELLILG-KPYPGLNVLDVKEKLER 319
                  *******************************88.6*********9999976 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.014
                  SBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 230 cpeelyelmkkcweedpeeRptfselvekl 259
                   ++++ +l+++ w+ed +eR + +++ve+l
   EFC37405.1 366 QCRNFISLIEDMWKEDVSERLSSKQVVERL 395
                  45677899*****************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (403 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       875  (0.0488036); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2483.38
//
Query:       EFC37406.1  [L=715]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.2e-06   25.7   0.0      1e-05   24.9   0.0    1.3  1  Hydrolase_4    Serine aminopeptidase, S33
     0.0033   16.3   0.0     0.0073   15.1   0.0    1.5  1  Peptidase_S28  Serine carboxypeptidase S28


Domain annotation for each model (and alignments):
>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.0   1.2e-09     1e-05      57     127 ..     172     241 ..     169     275 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 1.2e-09
  Hydrolase_4  57 dyvdDlaafvekvkeehpel.plfllGhSmGGliallyllrypdkvaglilsaPalkikaklkappllklll 127
                  d + D++ + + v+e+h++   ++l G SmGG+i++ + + +p+ ++g++++++al++++k    pl +l+l
   EFC37406.1 172 DAILDVNNLRNYVEEKHGQIkCCILEGRSMGGAIVTFISELHPHLYDGAVCIGAALRVDQK--EEPLPHLVL 241
                  66779999999999999888456777*********************************88..455555544 PP

>> Peptidase_S28  Serine carboxypeptidase S28
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   8.2e-07    0.0073      90     201 ..     171     286 ..     160     320 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 8.2e-07
  Peptidase_S28  90 eqaLaDlasfikalkqkfklsssskwitfGgSYsgsLaawarkkyPelvvgavaSSaPllakvdfkeylevvetslakvag....ecakaveqgfa 181
                    + a+ D+ + ++ +++k+   + +  i+ G+S +g++++++ +++P+l +gav   a+l+         ++v ++  k  +    ++++++++ f+
     EFC37406.1 171 KDAILDVNNLRNYVEEKH--GQIKCCILEGRSMGGAIVTFISELHPHLYDGAVCIGAALRVDQKEEPLPHLVLQNTPKFPIigwsCNYDQIDRRFK 264
                    568999999999999666..677779********************************99877777777777777766665666557888888887 PP

  Peptidase_S28 182 eveel..lktkegrqalkeelq 201
                     ve +  l+ + g+ +++++ q
     EFC37406.1 265 PVEVMneLNNDVGNSNVEFNHQ 286
                    7665511344445555544444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (715 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       771  (0.043003); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.35s 00:00:01.08 Elapsed: 00:00:00.56
# Mc/sec: 3871.45
//
Query:       EFC37407.1  [L=453]
Description: beta-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.9e-55  188.1   0.1    3.5e-55  187.3   0.1    1.4  1  Tubulin    Tubulin/FtsZ family, GTPase domain
    1.3e-26   93.2   0.3      2e-26   92.6   0.3    1.3  1  Tubulin_C  Tubulin C-terminal domain
      0.002   17.9   0.0     0.0039   16.9   0.0    1.6  1  Tubulin_3  Tubulin domain


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  187.3   0.1   5.9e-59   3.5e-55       1     195 [.       3     221 ..       3     223 .. 0.96

  Alignments for each domain:
  == domain 1  score: 187.3 bits;  conditional E-value: 5.9e-59
                 EEEEEEEHHHHHHHHHHHHH....HHHCH.......................HHHT.....TTEEEEE....EEESBHHHHHTS-GS........EEEE CS
     Tubulin   1 eiivigvGqcGnqignelwella.kehgiqsdg...................dslesfFsesgkveyiprsvaidtdpqvlneikags..elfnpnkll 77 
                 e+i+++vG+cGn+ig +++e +a +eh+i ++g                     +++fF+es++++  pr+v++d++p  +++i++ +  ++f+++   
  EFC37407.1   3 EVIHVQVGGCGNHIGYQFYERIAkHEHSILPNGeksltrnheniytdideenYYTNVFFEESKSGRWSPRAVLADLEPYSIDQIQQLEygRIFKSEYNA 101
                 799*****************77625899988889**************99887789******************************************* PP

                 --CCCCTTC--TT-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--..GG.G-HHHHHHHHHHH CS
     Tubulin  78 lgkegagnngaggypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs..efsevvvepynailal 174
                 + + gag+n+a+g++++g+e+ + ++e +rk++e+c +lqgf++++slgGG+GSG g++++++l+eeyp+++v +++v+Ps    s++ ve yn +la 
  EFC37407.1 102 IYQYGAGGNWAKGHYTIGAECVDNVMEVVRKQAENCGNLQGFQLMHSLGGGSGSGWGTLVISKLREEYPDKIVSSCSVFPSlkASSTNPVEAYNCVLAF 200
                 **********************************************************************************9899************* PP

                 HHHHHT-SEEEEEEHHHHHCC CS
     Tubulin 175 kelieesdavividNdaLlki 195
                 ++lie+ d+v ++dN+aL++i
  EFC37407.1 201 HQLIENTDFVSCFDNEALIEI 221
                 ******************998 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.6   0.3   3.4e-30     2e-26       1     124 [.     271     388 ..     271     390 .. 0.92

  Alignments for each domain:
  == domain 1  score: 92.6 bits;  conditional E-value: 3.4e-30
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEESSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEECECT CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirGdvepkevnkavqrikekkkaqfveWiptgikvalnkkspy 99 
                 PrlhF ++s +P++++++   +++++++++++l +p+n+m+ +dpr+g+y+a+++l+rG ++ kevn+  +++ +k++++ v+W+p ++k +++kk+  
  EFC37407.1 271 PRLHFATISHTPISADSN--NSSKNISELFQNLTSPNNVMCGCDPRSGRYMAAIALFRGSMTLKEVNDVASSVSNKNSSNWVDWMPPNLKSNVCKKKSG 367
                 9*************9965..5566799********************************************************************9876 PP

                 -TTTSSCEEEEEEEEGGGHHHHHHH CS
   Tubulin_C 100 vkkqskvsvlmlaNttsiaelfkrl 124
                   ++    ++++aN+tsi+ l+ ++
  EFC37407.1 368 DFES----ATLIANSTSIRFLLTNI 388
                 6655....5*********9888776 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   6.5e-07    0.0039      63     108 ..     129     175 ..      79     226 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 6.5e-07
   Tubulin_3  63 dlrpfaeecdqlrglqvftgvddaWG.Gfaakylerlrdeygkksil 108
                  +r+ ae+c +l+g+q++ +     G G+++  + +lr+ey+ k + 
  EFC37407.1 129 VVRKQAENCGNLQGFQLMHSLGGGSGsGWGTLVISKLREEYPDKIVS 175
                 47999***************99877669**************99763 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (453 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       531  (0.0296168); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 2642.73
//
Query:       EFC37408.1  [L=399]
Description: hypothetical protein NAEGRDRAFT_59749 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.01   15.8   0.5      0.019   15.0   0.5    1.5  1  TF_AP-2   Transcription factor AP-2


Domain annotation for each model (and alignments):
>> TF_AP-2  Transcription factor AP-2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.5     1e-06     0.019      82     151 ..      95     163 ..      49     174 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1e-06
     TF_AP-2  82 lvEgEavhlakDleklceeefpakaiaeelvkealedenlelekrkekleaakqilkelkdllesdrppl 151
                 + ++E  hla+++++  +e+  +++++ee   ++  +e+ e++++ + l++++++l++l++lle+ +p +
  EFC37408.1  95 ISQEELNHLAEQVQAEDKEQRLKDRLSEEYEIQQRLKEK-EVNHLSSLLQSSRKTLSSLAELLEQTKPTM 163
                 6789************99999999999888666665777.9************************99874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2190  (0.122148); expected 358.6 (0.02)
Passed bias filter:                      617  (0.0344135); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.29s 00:00:01.01 Elapsed: 00:00:00.50
# Mc/sec: 2409.68
//
Query:       EFC37409.1  [L=803]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (803 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       813  (0.0453455); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.24s 00:00:00.90 Elapsed: 00:00:00.42
# Mc/sec: 5686.91
//
Query:       EFC37410.1  [L=522]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-06   28.6   0.7    3.3e-06   27.3   0.7    1.7  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.7   1.9e-10   3.3e-06       3      93 ..     365     482 ..     363     496 .. 0.82

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 1.9e-10
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCS CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkka...................keqeelkkkakeIyneylapsspkelnidkklreelekrlek 82 
                 e +l+dq++ +++ +F ++++s e + F+++++++k+                    + + ++++ +++I+  yl ++s +elni++  +++le   + 
  EFC37410.1 365 ECVLNDQKLFNILIDFSRRSYSPESVLFYKDIQHYKQLvaklemmengafqhvesikNLRVKITRFVQNIVHVYLCEGSVNELNIPNLKMKKLELTNKI 463
                 5689**********************************************9998887777788888*******************99877777654333 PP

                 S........STTTTTTHHH CS
         RGS  83 e........qpsrklfeea 93 
                 +        + +r+lf+ +
  EFC37410.1 464 AaciefesnRFTRDLFDSI 482
                 3555555666666777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1271  (0.0708907); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2968.60
//
Query:       EFC37411.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-11   44.1   0.3    2.9e-11   43.7   0.3    1.1  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.7   0.3   1.6e-15   2.9e-11       2      96 ..      14     135 ..      13     141 .. 0.88

  Alignments for each domain:
  == domain 1  score: 43.7 bits;  conditional E-value: 1.6e-15
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS....................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-..HHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka....................keqeelkkkakeIyneylapsspkelnid..kklreelek 78 
                 +es+l+++  ++++ +F +++f+ e + F+++v+++kk                     k++++++k + +I++ yla++s +eln++  k lr+ +++
  EFC37411.1  14 IESVLNNKETLKVLLDFARRSFCPEGILFYKDVQHYKKLvikyqdhefntafhntetikKHRSNVQKLVSNIVKSYLAEGSVNELNLPnvKILRNDINA 112
                 689*******************************************************9999*************************933358888888 PP

                 HHCSS.....STTTTTTHHHHHH CS
         RGS  79 rleke.....qpsrklfeeaqee 96 
                 +l +          +lf+ aq e
  EFC37411.1 113 KLAELehnhsPYPVDLFDSAQVE 135
                 88776666655566788888766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       825  (0.0460148); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1035.92
//
Query:       EFC37412.1  [L=561]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      7e-35  121.2   0.0    8.8e-35  120.9   0.0    1.1  1  DAO            FAD dependent oxidoreductase
    4.5e-17   62.3   6.8      1e-16   61.1   6.8    1.6  1  Ribosomal_L44  Ribosomal protein L44
    2.1e-14   53.2   1.7    4.1e-14   52.3   0.5    2.1  2  Rieske         Rieske [2Fe-2S] domain
      2e-06   27.2   0.2    0.00031   20.1   0.1    2.2  2  Pyr_redox_2    Pyridine nucleotide-disulphide oxidoreductase
    6.7e-06   25.6   0.4     0.0012   18.1   0.2    2.3  2  Pyr_redox_3    Pyridine nucleotide-disulphide oxidoreductase
    1.2e-05   24.2   0.2      0.041   12.6   0.3    2.2  2  HI0933_like    HI0933-like protein
      2e-05   23.9   1.0    5.3e-05   22.5   0.3    1.9  2  FAD_binding_2  FAD binding domain
     0.0002   21.9   0.3     0.0086   16.6   0.4    2.5  2  Pyr_redox      Pyridine nucleotide-disulphide oxidoreductase
     0.0013   18.2   0.1      0.002   17.6   0.1    1.3  1  FAD_oxidored   FAD dependent oxidoreductase
     0.0014   17.9   0.0     0.0021   17.4   0.0    1.3  1  FAD_binding_3  FAD binding domain
     0.0016   18.6   0.4      0.005   17.0   0.4    1.9  1  NAD_binding_8  NAD(P)-binding Rossmann-like domain
  ------ inclusion threshold ------
       0.01   16.3   0.1      0.021   15.3   0.1    1.5  1  NAD_binding_7  Putative NAD(P)-binding
      0.011   15.1   0.1       0.03   13.6   0.1    1.7  1  Thi4           Thi4 family
      0.014   14.7   0.1       0.21   10.8   0.0    2.1  2  Amino_oxidase  Flavin containing amine oxidoreductase


Domain annotation for each model (and alignments):
>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  120.9   0.0   6.9e-38   8.8e-35       1     351 [.      67     420 ..      67     421 .. 0.81

  Alignments for each domain:
  == domain 1  score: 120.9 bits;  conditional E-value: 6.9e-38
                 EEEEECTSHHHHHHHHHHHHTT..EEEEESSSSTTSSGGGSSEEEEESSS.......STHHSTH........HHHHHHHHHHHHHHHHHHHHSSTTSEE CS
         DAO   1 dvviiGGGiiGlstAyeLarrg..VtllekgdiagsgaSgrnsgllhsgl.......rylpeas........elarlslealeelreleeelgididyr 82 
                 dv+++GGG++Gl tA+ L ++g  V+++e+g ++gsg S ++++ +++ +       +              ++a++  ++++e+    +++gi++d+ 
  EFC37412.1  67 DVCVVGGGVFGLQTALKLVEKGkkVAIVESG-QVGSGVSNNTTAKVSALHsiiyskiE-----KkfnrsvssQYAQMNMAGVREMGNTIKKYGIECDWT 159
                 9********************99********.9************9997776654330.....145677777999**********999999******** PP

                 EEEEEEEESSHHHHHHHHHHHHHHHHTTT.TEEEEEHHHHHHHS.TTSTTTSEEEEETTEEEEEHHHHHHHHHHHHHHTT-EEEESECEEEEEEEETCE CS
         DAO  83 rtGllslaadeeelealdkllallleagl.daelldaeevrele.palpgllgalfypdtgqvdpakltaalaraaealGveilegtevtgleeedgkv 179
                 ++ ++ +a +++el  +++++++++ agl  + ++ ++ ++e+  p     +ga+  +d+ +++ ++++++la+a+e+ Gv i+e+++v g+e      
  EFC37412.1 160 KSDSYTVALSDSELRIVQDEIDAANHAGLyGVDYIYPDHLKEIPfP----NKGAIRLKDQYVFNSFAYCQGLAKALEKSGVFIYENSRVHGVEYA--SP 252
                 ********9888899999999999778885557999*988888734....59*******9********************************654..24 PP

                 EEEEEECT.EEEEEEEEEEE--GGGHHHHHTTCTTTSEEEEEEEEEEEEEECCTHSTGSGCSEEEEE..EEETTTTEEEEEETTSEEEE.EESSEEETT CS
         DAO 180 wgverttp.gendaadavVnaaGawsdllgllkeldlpispvrgqvlvlkplseklvspaailpvpe..tdddgrgvyvtprkdgrvlv.Ggtadeesg 274
                 + +   t+ g++  ad+vV+a+ +   +l++ + +   i++  ++ +++ + +e   +p  i ++    + d+++   ++  ++g++l+  g+  + + 
  EFC37412.1 253 HII--STNeGNV-MADKVVIATHLP--ILDRSGHF-SVIEAQSSYCVAF-KMKEGVKAP--IGNYITigKCDEFGIKSIRSAENGKILIiAGNSNKCGE 342
                 455..5565765.559******755..34222333.3556666666666.777755444..333333468888999999999****9976777779999 PP

                 CSSTSCSHHHHHHHHHHHHHHSGGGCGEEEEEEEEEE.ETTSSEEEEE.EETEEEEEEEEECTTTHHHHHHHHHHHHHH CS
         DAO 275 dddpevdeedidellealrklfPqlgdvlrkwaGlrp.lpdglplige.tpgvkglylatGhsghGltlapatGkllae 351
                 ++++  +++ +d l+e   + f   ++    w+ l   + d+ p++g  ++g + +y atG+  +G+++  a+  ++++
  EFC37412.1 343 FHPTGNSQDIYDNLIEFGFNNFKV-EKAICGWSALDYfTADTIPYFGLlHHGINTVYTATGCRKWGFSNLSAASLIVSD 420
                 9998999999999*********77.566668996555668********555888****************998777766 PP

>> Ribosomal_L44  Ribosomal protein L44
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.1   6.8   8.2e-20     1e-16       1      52 [.      17      68 ..      17      71 .. 0.97

  Alignments for each domain:
  == domain 1  score: 61.1 bits;  conditional E-value: 8.2e-20
                   EEEEEEEEE-------SSSHHHHHHHH.H-SSSGGGGS----.--SSBB--E CS
  Ribosomal_L44  1 kHtehkveqykkgkdselaqgkRrydrkqsgygGqtkpvfkkkaKttKKivl 52
                   +H+ehkv+qyk+gk++  a+g+R y  kq+gygGqt p+f+kkaKttKKi++
     EFC37412.1 17 THKEHKVSQYKAGKTRRTAKGQRFYVIKQKGYGGQTMPIFHKKAKTTKKIDV 68
                   6*************************************************96 PP

>> Rieske  Rieske [2Fe-2S] domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       3.2   4.1e+03       7      30 ..      22      44 ..       7      53 .. 0.57
   2 !   52.3   0.5   3.2e-17   4.1e-14      23      86 ..     492     554 ..     471     557 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 3.2
                EGGGC-TTCEEEEEETTEEEEEEE CS
      Rieske  7 kesdvpegdpltvkvggeplvvlr 30
                k+s+ + g+ ++ +  g+++ v++
  EFC37412.1 22 KVSQYKAGK-TRRTAKGQRFYVIK 44
                344444444.33335555566665 PP

  == domain 2  score: 52.3 bits;  conditional E-value: 3.2e-17
                 TEEEEEEE-TTS-EEEEESC-TTTT-BCGGSEEETT.EEE-TTT--EEE.TTSBEEE-TTHHHEE CS
      Rieske  23 geplvvlrdedgevyAlsdvCtHrgaplsegkidekgvleCpcHgwayd.adGkvikgPaprpla 86 
                  e+++ +rd +ge++ ++ +CtH+g++l+ ++  ek ++ C+cHg++++ +dG+vi+gPa +pl 
  EFC37412.1 492 LETIAAYRDGKGEYHLFHPTCTHLGCHLDYNNA-EK-TFDCSCHGSRFKaTDGEVIHGPAVKPLT 554
                 4678999*99******************99888.67.9***********************9986 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.1   2.4e-07   0.00031       2      54 ..      67     127 ..      66     182 .. 0.65
   2 !    5.0   0.0    0.0097        12     189     235 ..     227     271 ..     221     273 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 2.4e-07
                  SEEEE--SHHHHHHHHHHHHHTS-EEEEE........TTHCHHHCSHHHHCHHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaqagakvtlve........legtclnggcllskallgvaedae 54 
                  dv+v+GgG+ Gl++al+l ++g kv++ve        +++t+  +  l s ++ +++++ +
   EFC37412.1  67 DVCVVGGGVFGLQTALKLVEKGKKVAIVEsgqvgsgvSNNTTAKVSALHSIIYSKIEKKFN 127
                  89**************************866644554444444444444444444333333 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0097
                  HHHHHHHTTEEEEESCEEEEEEETTEEEEEEETTSCEEEESEEEE-S CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 189 leealekeGvevklgtsvkeidgngeklevvledgeeidadlvvvav 235
                  l++alek+Gv ++ +++v+ ++  +   + + +++  + ad vv+a+
   EFC37412.1 227 LAKALEKSGVFIYENSRVHGVEYASP--HIISTNEGNVMADKVVIAT 271
                  6799***************9998887..6666666678999999986 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.2   9.6e-07    0.0012     157     242 ..      58     146 ..      38     168 .. 0.64
   2 !    5.2   0.0    0.0082        10      83     132 ..     223     271 ..     199     274 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 9.6e-07
  Pyr_redox_3 157 kefhkyagqkvvViGgknSavDaAlelvrkgaeVtvvtrgse...iekeesdpsyslkpdienrleelvkeekikvlfnaevkeikeke 242
                  k+++ +++ +v+V+Gg+  +  +Al+lv+kg++V +v +g+    ++++ +     l  +i +++e+  +++    + + ++  ++e+ 
   EFC37412.1  58 KKAKTTKKIDVCVVGGGVFGLQTALKLVEKGKKVAIVESGQVgsgVSNNTTAKVSALHSIIYSKIEKKFNRSVSSQYAQMNMAGVREMG 146
                  4556678899999****99************9999999986511144444444445666666666666555333334444444444444 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0082
  Pyr_redox_3  83 aleYlrevaksfelpiklfeeVesvkkedegfevetsketyeAkkviiAt 132
                  + + l++  ++  + i ++++V  v+ ++   +++t+++++ A+kv+iAt
   EFC37412.1 223 YCQGLAKALEKSGVFIYENSRVHGVEYAS-PHIISTNEGNVMADKVVIAT 271
                  5556677788888999999******9985.678****************8 PP

>> HI0933_like  HI0933-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.3   3.2e-05     0.041       2      35 ..      67      99 ..      66     152 .. 0.75
   2 !    9.4   0.0    0.0003      0.39     114     162 ..     226     271 ..     219     274 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.2e-05
                 SEEEE--SHHHHHHHHHHHHTT--EEEE-SSSSS CS
  HI0933_like  2 dviviGgGaAGlmaAisaakrgkrVlllekakkl 35
                 dv v+GgG  Gl +A+++ ++gk+V+++e+++ +
   EFC37412.1 67 DVCVVGGGVFGLQTALKLVEKGKKVAIVESGQ-V 99
                 89***************************983.3 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0003
                  HHHHHHHHHT-EEE-S--EEEEECETTE.EEEEE.TTEEEEESEEEE-- CS
  HI0933_like 114 allkelkeagvklrletevksvekeedgkfrvktkseeeleadklvlAt 162
                   l k+l+++gv ++ +++v++ve+ + +   ++t +e+++ adk+v+At
   EFC37412.1 226 GLAKALEKSGVFIYENSRVHGVEYASPH--IIST-NEGNVMADKVVIAT 271
                  68999*****************776555..8999.9************7 PP

>> FAD_binding_2  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.3   4.2e-08   5.3e-05       1      36 [.      67     102 ..      67     144 .. 0.85
   2 ?   -0.8   0.0      0.49   6.2e+02     168     199 ..     238     271 ..     233     272 .. 0.88

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 4.2e-08
                    SEEEE--SHHHHHHHHHHHHTTT-EEEEESSSGGGS CS
  FAD_binding_2   1 DviViGsGlAGLaAAleaaeaGlkvavvekeqefgg 36 
                    Dv V+G+G+ GL  Al++ e+G+kva+ve +q+ +g
     EFC37412.1  67 DVCVVGGGVFGLQTALKLVEKGKKVAIVESGQVGSG 102
                    99******************************9666 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.49
                    EECTTEEEEEEEEET..TTTCEEEEEESEEEE-- CS
  FAD_binding_2 168 ivedgrvtGavvenp..esgrevrirakavvlat 199
                    i+e+ rv+G++ + p   s +e  + a++vv+at
     EFC37412.1 238 IYENSRVHGVEYASPhiISTNEGNVMADKVVIAT 271
                    78999********9999788888899****9998 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.4   6.7e-06    0.0086       2      31 ..      68      97 ..      67     124 .. 0.87
   2 ?    2.3   0.0       0.2   2.5e+02      46      68 ..     227     249 ..     223     258 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 6.7e-06
                EEEECSSHHHHHHHHHHHHTTSEEEEEESS CS
   Pyr_redox  2 vvvvGgGyiglElAgalaelgkkVtvvers 31
                v vvGgG+ gl  A  l e gkkV +ve +
  EFC37412.1 68 VCVVGGGVFGLQTALKLVEKGKKVAIVESG 97
                78*************************976 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.2
                 HHHHHHHTTEEEECSEEEEEEEE CS
   Pyr_redox  46 lqeklekngievllntkveeieg 68 
                 l++ lek g+ ++ n++v  +e 
  EFC37412.1 227 LAKALEKSGVFIYENSRVHGVEY 249
                 6899**************99884 PP

>> FAD_oxidored  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.1   1.6e-06     0.002       1      34 [.      67     100 ..      67     170 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.6e-06
  FAD_oxidored   1 DvvVvGGgpaGvaAAiaAaraGakvlLveergvl 34 
                   Dv+VvGGg+ G+  A+   ++G+kv++ve  +v 
    EFC37412.1  67 DVCVVGGGVFGLQTALKLVEKGKKVAIVESGQVG 100
                   9****************************98764 PP

>> FAD_binding_3  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   1.6e-06    0.0021       2      33 ..      66      97 ..      65     169 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.6e-06
                   EEEEEE--SHHHHHHHHHHHHTTHHEEEEESS CS
  FAD_binding_3  2 tdVlIVGaGpaGlmlallLseaGvrvvlvekr 33
                   +dV++VG+G  Gl +al L e+G +v +ve  
     EFC37412.1 66 IDVCVVGGGVFGLQTALKLVEKGKKVAIVESG 97
                   79***************************975 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.4   3.9e-06     0.005       1      33 [.      70     102 ..      70     115 .. 0.89

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3.9e-06
                    EE--SHHHHHHHHHHHCCTEEEEEE-SSSSSSG CS
  NAD_binding_8   1 IvGaGlsGlvaAylLakagfdvlllekrdrlGG 33 
                    +vG+G++Gl +A  L ++g++v ++e+++  +G
     EFC37412.1  70 VVGGGVFGLQTALKLVEKGKKVAIVESGQVGSG 102
                    8*************************9976555 PP

>> NAD_binding_7  Putative NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.3   0.1   1.6e-05     0.021       7      40 ..      65      98 ..      60     174 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1.6e-05
  NAD_binding_7  7 gkkvlvvGgGevAarkvrklleagakvtvvapev 40
                   +  v+vvGgG  +++ + kl+e+g+kv +v    
     EFC37412.1 65 KIDVCVVGGGVFGLQTALKLVEKGKKVAIVESGQ 98
                   5679*************************76553 PP

>> Thi4  Thi4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1   2.3e-05      0.03      15      50 ..      63      97 ..      54     142 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.3e-05
                HTEEEEEEE--SHHHHHHHHHHHHCTTS-EEEEESS CS
        Thi4 15 yaesDvvivGaGssGLtaayylakkpdlkvailers 50
                  + Dv +vG+G  GL +a  l +k + kvai+e+ 
  EFC37412.1 63 TKKIDVCVVGGGVFGLQTALKLVEK-GKKVAIVESG 97
                5678*********************.********74 PP

>> Amino_oxidase  Flavin containing amine oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.11   1.5e+02       3      23 ..      77      97 ..      77     100 .. 0.93
   2 ?   10.8   0.0   0.00016      0.21     216     266 ..     227     277 ..     222     288 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.11
                   HHHHHHHHHHTTEEEEEEESS CS
  Amino_oxidase  3 GLaaArqLlsaGfdVtvlEar 23
                   GL +A +L ++G +V ++E+ 
     EFC37412.1 77 GLQTALKLVEKGKKVAIVESG 97
                   999****************86 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00016
                    HHH..TTTTEEEETSEEEEEEEE.ETTCEEEEETTSTEEEESEEEE-S-HHHHH CS
  Amino_oxidase 216 lae..elrgldirlntrVkeikr.egdgvtvtledgevveaDaVvvTvplgvlk 266
                    la+  e++g+ i  n+rV+ +++ +++ +++    g+v  aD+Vv+++ l+ l 
     EFC37412.1 227 LAKalEKSGVFIYENSRVHGVEYaSPHIIST--NEGNV-MADKVVIATHLPILD 277
                    4444556****************55555555..47776.9*********99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (561 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       589  (0.0328518); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.40
# Mc/sec: 4178.69
//
Query:       EFC37413.1  [L=962]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-05   24.2   0.0    5.6e-05   22.8   0.0    1.7  1  hSac2     Inositol phosphatase


Domain annotation for each model (and alignments):
>> hSac2  Inositol phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   3.1e-09   5.6e-05      25      69 ..     584     624 ..     576     638 .. 0.88

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 3.1e-09
       hSac2  25 edeeflggWlLlspdesntksekeeervlLLTdkalyickydfnl 69 
                  +ee+++gW ++++++++      ++r l+LTdka+   kyd ++
  EFC37413.1 584 YHEEIIKGWHVIKVNKHQI----NQDRYLILTDKAYWTLKYDAKT 624
                 579**************98....*******************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (962 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1368  (0.076301); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.29s 00:00:01.04 Elapsed: 00:00:00.47
# Mc/sec: 6168.22
//
Query:       EFC37414.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.7e-38  130.6   0.0    5.6e-38  130.3   0.0    1.1  1  DJ-1_PfpI  DJ-1/PfpI family
     0.0019   18.0   0.0     0.0026   17.5   0.0    1.2  1  GATase     Glutamine amidotransferase class-I
  ------ inclusion threshold ------
      0.083   12.6   0.0       0.27   10.9   0.0    1.9  1  ThiJ_like  ThiJ/PfpI family-like


Domain annotation for each model (and alignments):
>> DJ-1_PfpI  DJ-1/PfpI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  130.3   0.0   9.3e-42   5.6e-38       4     164 ..       7     189 ..       4     190 .. 0.94

  Alignments for each domain:
  == domain 1  score: 130.3 bits;  conditional E-value: 9.3e-42
                 EEEEETTBEHHHHHHHHHHHHHTTEEEEEEESS.................TSEEEETTSEEEE-SEEGGGCTCC..G-SEEEE--BHHHHHHHHTSHHH CS
   DJ-1_PfpI   4 lvlladgvedvElivpvdvlkragikvdvvsvd.................keevkgsrGlkvtvdaslddvkaa..eyDalvlpGGragperlrenekv 83 
                 +++++d+ved+E++vp+++l   g++v+v+s++                 ++++++ +G+++ ++a +ddv ++  ++  l+lpGGr  +e+lr ++ v
  EFC37414.1   7 ILIVGDYVEDYEAMVPYQALTMVGHSVSVISPGkkkgdkvvtaihdflpgEQTYTELKGHNFAITADFDDVLSNldNFGGLILPGGRC-SEYLRLHDNV 104
                 57889********************************************999*******************66555************.********** PP

                 HHHHHHHHHTT-EEEEETTTHHHHHH.TTTTTTSEE--SGGGHHHHHHTTSEE-SS...SEEEETTEEEESSGGGHHHHHHHHHH CS
   DJ-1_PfpI  84 velvkefaekgklvaaICagpqlLaa.agvlkgrrvTsypavkdklekagakyvdk...rvvvdgnlvTsrgpgaaiefalelle 164
                 +++vk+f+ek+k++aaIC+gp++L    + lkg+r+++y+a+k +++++ga+yv      +vv++n+vT  +++ ++++++++l+
  EFC37414.1 105 LTIVKHFLEKKKPIAAICHGPLILTPfPEHLKGKRISAYFACKHDIQNTGAEYVQCgaeDAVVSDNIVTGVAWPGHPKWLRAFLD 189
                 *********************888873689************************8777799*******************99985 PP

>> GATase  Glutamine amidotransferase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   4.4e-07    0.0026      29      80 ..      70     124 ..      43     130 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 4.4e-07
                 TTSHHHHHHHTHHSTSEEEEEEESSCTT...TTTHHHHHHHHCTSTS-EEEETHH CS
      GATase  29 idasaeeilellknpdgilvsgGpgspg...vegkieaikearenkiPiLGICLG 80 
                 i+a+++  l++l+n+ g++++gG +s +    ++ ++++k+++e+k+Pi  IC G
  EFC37414.1  70 ITADFDDVLSNLDNFGGLILPGGRCSEYlrlHDNVLTIVKHFLEKKKPIAAICHG 124
                 4445555554699*****************9999*******************98 PP

>> ThiJ_like  ThiJ/PfpI family-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   4.4e-05      0.27      68     139 ..      67     129 ..      13     158 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 4.4e-05
   ThiJ_like  68 eFkeplslssesFsleeydlvllpGGsdkavrelleserlhsllveylklvkrekepskvlgaicqgvlala 139
                 +F     + +   +l+++  + lpGG+       l   rlh+ +   +   k+  e++k ++aic+g l l+
  EFC37414.1  67 NFAITADFDDVLSNLDNFGGLILPGGRCSEY---L---RLHDNVLTIV---KHFLEKKKPIAAICHGPLILT 129
                 4555555555555899999999999985543...3...4444443332...3333889*********88775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       363  (0.0202465); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1252.44
//
Query:       EFC37415.1  [L=489]
Description: phosphatidylcholine-sterol acyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-33  116.5   3.1    1.3e-25   90.4   0.4    2.1  2  LCAT           Lecithin:cholesterol acyltransferase
     0.0012   18.4   0.0     0.0025   17.4   0.0    1.5  1  DUF676         Putative serine esterase (DUF676)
  ------ inclusion threshold ------
      0.034   13.9   0.2       0.63    9.7   0.0    2.2  2  PGAP1          PGAP1-like protein
      0.052   13.2   0.1      0.099   12.3   0.1    1.6  1  Abhydrolase_1  alpha/beta hydrolase fold
      0.097   11.9   0.0       0.18   11.0   0.0    1.5  1  Hydrolase_4    Serine aminopeptidase, S33


Domain annotation for each model (and alignments):
>> LCAT  Lecithin:cholesterol acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.4   0.4   3.6e-29   1.3e-25       5     217 ..     122     343 ..     120     369 .. 0.76
   2 !   27.2   0.4   5.6e-10     2e-06     278     388 ..     367     471 ..     339     475 .. 0.76

  Alignments for each domain:
  == domain 1  score: 90.4 bits;  conditional E-value: 3.6e-29
        LCAT   5 elWldldmllslvvd.cwlknlelvldkstgl.qedapgvki..RadqGfeaieyldkskiagkqyeiwkklvknlvkiG.yeknktvvaapYDWRls. 97 
                 ++W +l+ l++ +++ c ++++ +  + + gl  ++  gv+i  +  +G+   e    ++++ k y   k l + lvk+G ++ +k++++   DWRl  
  EFC37415.1 122 QIWMSLEELVPFFTEdCFVHDMSI--ELKDGLlRQKDSGVRIfgKDIGGMGGLESV-FAQLESKAY-YMKYLSDYLVKYGnFQIGKSLRGLTIDWRLGv 216
                 7**********99877****6655..444444023566777776444566555554.467887777.45667899*****67889************99 PP

        LCAT  98 ......leerdkYfskLkelieealk.lsgkkvvliaHSmGnllvlyflkwveaeaWvdqhikafislgapllGsvkavkallsGenkgipvlseltlr 189
                       ++     f  Lk+l+e ++  +++ kv l++HSmG+  + yfl + +++ W+dq+i+ fi l++++ Gs+ a+ + + G n g+p+++ +++r
  EFC37415.1 217 kewsnnNNTIGGDFYTLKSLVEDTYYkNGNLKVSLLGHSMGGPFLQYFLANFVNQVWKDQYISNFIPLSGAFDGSPIALILYMTGTNWGLPIFELENAR 315
                 8885332222233679*****9887659999******************************************************************** PP

        LCAT 190 vlsksfssslsllPkgeevlwkdvawps 217
                 ++ +  +s l + P+   + +  + +++
  EFC37415.1 316 KILHQYPSPLYMSPNYSPFQYPFFTYNN 343
                 **99999999999944433333333333 PP

  == domain 2  score: 27.2 bits;  conditional E-value: 5.6e-10
        LCAT 278 lkk...lkkkkyvkeeetklpeaPgvkvyciygvglptergyvyapekkssplnyilsdidyeteesivskdGdetvpkeslelCkkWqdnkakvkvtv 373
                 +k+   l++++y+  +  k+  aP+v ++c+yg g pt     y   k+ s ln+    +     + + ++dGd++vp  sl++C++ + +++k+ v +
  EFC37415.1 367 IKNgfeLYQHEYSAYKYNKI-AAPNVTTHCLYGYGIPTITHVEYSGPKEMSELNFN---DLVHGMNILKVEDGDGVVPSYSLQICDEFA-KYQKQPVYI 460
                 33344366666666555555.589***********************999999998...77778888889*******************.9******** PP

        LCAT 374 aelkeekrsaehvel 388
                 +      + a+h  +
  EFC37415.1 461 HRF----FNASHTGI 471
                 998....66666655 PP

>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0     7e-07    0.0025      73     129 ..     242     291 ..     218     321 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 7e-07
      DUF676  73 kkkdknkkiSfvghSlGgliaraaiaklkekemtlkeaikglepvtfitlasPhLGv 129
                   k++n k+S++ghS+Gg++ ++ +a   ++      + k+ ++ +fi l++ + G+
  EFC37415.1 242 Y-KNGNLKVSLLGHSMGGPFLQYFLANFVNQ------VWKDQYISNFIPLSGAFDGS 291
                 3.34458*******************76633......45678999***999977664 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0   0.00017      0.63      86     108 ..     242     264 ..     230     301 .. 0.66
   2 ?    1.6   0.3     0.053   1.9e+02      34      85 ..     324     376 ..     312     387 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00017
       PGAP1  86 sekeptsviliGHSmGGivaraa 108
                  ++ + +v l+GHSmGG   +  
  EFC37415.1 242 YKNGNLKVSLLGHSMGGPFLQYF 264
                 4677889**********766543 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.053
       PGAP1  34 lrkllknqnkkeldfftvdfneelsaldGrtlldqaeylnda.IkyIlslyss 85 
                      +n  ++++ fft++  + +   +  +l d  +++ da Ik+  +ly++
  EFC37415.1 324 PLYMSPNYSPFQYPFFTYNNTKVVKNYESSSLADIEKFMTDAkIKNGFELYQH 376
                 556678999999************************99999878888888854 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   2.8e-05     0.099      71     203 ..     245     385 ..     218     475 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.8e-05
                    TTSSEEEEEETHHHHHHHHHHHHH......GGGEEEEEEESE..CSSCCHHHHHHHHHHHHHHCHHCHHHHHHHHHHHHHHHHCCSCHHHHHHHHH CS
  Abhydrolase_1  71 gddkltlvGhSmGGmialayaaey......perVkalvllga..idpaaslieaqrqqaksfpdffdgyaadcarnpagplladelaaleqrhrlv 158
                    g+ k+ l+GhSmGG +  +++a +      ++++++++ l++    ++++li  +    +++p f   +a +   +   pl+ +++   +q+  ++
     EFC37415.1 245 GNLKVSLLGHSMGGPFLQYFLANFvnqvwkDQYISNFIPLSGafDGSPIALILYMTGTNWGLPIFELENARKILHQYPSPLYMSPNYSPFQYPFFT 340
                    5567889*****************999999999999998888666666666665555555555555555555555555555555555555553333 PP

                    HHHHHHCHHHCCHHHHHHHCH..HHHHHHHHHHHHHHHCCHHHHHHH CS
  Abhydrolase_1 159 dalkfpdkskrfpssgsdnas..slatgalksieqwpttdsaklllr 203
                    + +   +++k+++ss+ ++    +++++ ++ +e ++ ++sa+++++
     EFC37415.1 341 YNN--TKVVKNYESSSLADIEkfMTDAKIKNGFELYQHEYSAYKYNK 385
                    333..666666665555544322455555555555555555555555 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0     5e-05      0.18      62      94 ..     233     265 ..     216     362 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 5e-05
  Hydrolase_4  62 laafvekvkeehpelplfllGhSmGGliallyl 94 
                  l+++ve    ++++l++ llGhSmGG   + +l
   EFC37415.1 233 LKSLVEDTYYKNGNLKVSLLGHSMGGPFLQYFL 265
                  456777777888899***********7766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       628  (0.0350271); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 3012.47
//
Query:       EFC37416.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.1e-46  151.5  23.6     0.0011   18.8   0.0   12.4 12  LRR_6            Leucine Rich repeat
    1.5e-30  104.8  30.0    1.9e-09   37.1   0.4    6.5  9  LRR_8            Leucine rich repeat
    1.4e-21   76.1  27.9    4.5e-06   26.9   0.0    8.5  9  LRR_4            Leucine Rich repeats (2 copies)
      8e-16   56.2  14.3       0.85   10.4   0.3   11.3 11  LRR_1            Leucine Rich Repeat
    0.00012   21.6   7.1     0.0032   17.0   0.9    3.7  4  LRR_9            Leucine-rich repeat
    0.00019   21.3   1.1        4.5    7.1   0.1    5.2  6  DUF4347          Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
      0.041   13.7   0.4        9.3    6.1   0.0    3.0  3  PapC_C           PapC C-terminal domain
      0.056   13.9   0.8      0.056   13.9   0.8    2.9  3  DUF836           Glutaredoxin-like domain (DUF836)
       0.36   10.3   4.4         22    4.5   0.2    3.7  4  RNA_pol_I_TF     RNA polymerase I specific initiation factor
          2    8.2   4.8        4.8    7.0   0.6    3.6  3  Ribosomal_L12_N  Ribosomal protein L7/L12 dimerisation domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0    0.0023       4.1      13      24 .]      68      79 ..      66      79 .. 0.92
   2 !   15.2   0.0   9.1e-06     0.016       3      24 .]      82     103 ..      80     103 .. 0.91
   3 !   18.8   0.0   6.2e-07    0.0011       4      23 ..     107     126 ..     104     127 .. 0.90
   4 !    9.1   0.0   0.00081       1.5       4      24 .]     131     151 ..     128     151 .. 0.90
   5 !   12.7   0.2   5.9e-05      0.11       5      19 ..     156     170 ..     153     174 .. 0.89
   6 ?    4.3   0.0     0.029        52       5      23 ..     180     198 ..     176     199 .. 0.89
   7 !   13.0   0.3   4.7e-05     0.085       4      23 ..     203     222 ..     200     223 .. 0.89
   8 !   14.6   0.0   1.4e-05     0.025       5      24 .]     252     271 ..     249     271 .. 0.90
   9 !    8.2   0.0    0.0015       2.8       5      24 .]     276     295 ..     273     295 .. 0.92
  10 !   18.3   0.2   9.1e-07    0.0016       5      24 .]     300     319 ..     297     319 .. 0.94
  11 !   17.5   0.1   1.7e-06    0.0031       3      22 ..     322     341 ..     320     343 .. 0.88
  12 !   17.7   0.0   1.4e-06    0.0025       4      21 ..     347     364 ..     344     366 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0023
       LRR_6 13 NdIgDeGaeaLa 24
                N+Ig eG++ ++
  EFC37416.1 68 NCIGTEGVKHIC 79
                **********98 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 9.1e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L++  N+Ig eGa+ ++
  EFC37416.1  82 NNLTKLNIERNEIGEEGAKYIS 103
                 79****************9875 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 6.2e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  LteL++ +N+Ig eG+e +
  EFC37416.1 107 QLTELNVGWNGIGKEGVEFI 126
                 59***************987 PP

  == domain 4  score: 9.1 bits;  conditional E-value: 0.00081
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt L++  + I DeGa++++
  EFC37416.1 131 NLTLLEIEACRICDEGAKSIS 151
                 799999999*********996 PP

  == domain 5  score: 12.7 bits;  conditional E-value: 5.9e-05
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt+L++s+N+I++ G
  EFC37416.1 156 LTHLNISYNNISNLG 170
                 9**********9977 PP

  == domain 6  score: 4.3 bits;  conditional E-value: 0.029
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L L +++I+ eG++ +
  EFC37416.1 180 LTVLTLCDCNISEEGCKYI 198
                 99999**********9987 PP

  == domain 7  score: 13.0 bits;  conditional E-value: 4.7e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt Ld+s NdIg  G+e +
  EFC37416.1 203 QLTDLDISNNDIGCNGVEYI 222
                 69***********9999987 PP

  == domain 8  score: 14.6 bits;  conditional E-value: 1.4e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 +t L++s+N +gDeGa+ ++
  EFC37416.1 252 VTNLNISWNYVGDEGAKYIS 271
                 689*************9885 PP

  == domain 9  score: 8.2 bits;  conditional E-value: 0.0015
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++   dI+ eGa+ ++
  EFC37416.1 276 LTKLEVVRSDISTEGAKHIS 295
                 9****************986 PP

  == domain 10  score: 18.3 bits;  conditional E-value: 9.1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L++  N+Ig+eGa+a++
  EFC37416.1 300 LTDLNIGENNIGGEGAIAIS 319
                 9*****************96 PP

  == domain 11  score: 17.5 bits;  conditional E-value: 1.7e-06
       LRR_6   3 thLteLdLsgNdIgDeGaea 22 
                 + L+ Ld+s+N+Ig+ Gae 
  EFC37416.1 322 NQLRILDISDNNIGGIGAEH 341
                 569***************97 PP

  == domain 12  score: 17.7 bits;  conditional E-value: 1.4e-06
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                  Lt+Ld+s+N+Ig+ Ga+
  EFC37416.1 347 QLTHLDISHNCIGNYGAK 364
                 59************9998 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1      0.16   2.9e+02       6      28 ..      20      42 ..       6      48 .. 0.61
   2 !   13.7   0.0   2.1e-05     0.038      24      61 .]      81     118 ..      74     118 .. 0.88
   3 !   27.1   1.6   1.5e-09   2.6e-06       2      61 .]     131     190 ..     130     190 .. 0.95
   4 !   17.4   0.2   1.5e-06    0.0027       2      59 ..     179     236 ..     178     238 .. 0.94
   5 !   10.7   0.2   0.00019      0.33       2      59 ..     203     260 ..     202     262 .. 0.92
   6 !   13.9   0.1   1.9e-05     0.035       2      61 .]     251     310 ..     250     310 .. 0.88
   7 !   27.0   0.5   1.6e-09   2.8e-06       2      61 .]     275     334 ..     274     334 .. 0.98
   8 !   37.1   0.4   1.1e-12   1.9e-09       2      59 ..     299     356 ..     299     358 .. 0.97
   9 !   29.7   0.1   2.3e-10   4.1e-07       2      38 ..     323     359 ..     322     370 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.16
                EE-TTS--SEE-TTSSTT-TT-- CS
       LRR_8  6 LdLsnNrltslddeaFkglsnLk 28
                L+L + ++++l+ e+ ++ +nL+
  EFC37416.1 20 LSLLCKSIKKLQGEFLENIENLR 42
                55555555555555555544443 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2.1e-05
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++nL+ L++ +N++    ++ +s +++L++L++ +N +
  EFC37416.1  81 MNNLTKLNIERNEIGEEGAKYISKMKQLTELNVGWNGI 118
                 88999999999999999999999999999999999976 PP

  == domain 3  score: 27.1 bits;  conditional E-value: 1.5e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt L +   r+ + + ++ + l++L++L++s+N+++ l  + +  L++L+ L+L ++++
  EFC37416.1 131 NLTLLEIEACRICDEGAKSISELKQLTHLNISYNNISNLGSKYLTELKQLTVLTLCDCNI 190
                 8999**************************************************987765 PP

  == domain 4  score: 17.4 bits;  conditional E-value: 1.5e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+L L++ ++++ + +  + l++L+ Ld+snN +     + +sg+++L +L++ g+
  EFC37416.1 179 QLTVLTLCDCNISEEGCKYISELNQLTDLDISNNDIGCNGVEYISGMKQLLFLYIYGT 236
                 79************************************9999**********998775 PP

  == domain 5  score: 10.7 bits;  conditional E-value: 0.00019
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt Ld+snN +   + e  +g+++L  L++   ++   + + +s +++++ L++s+N
  EFC37416.1 203 QLTDLDISNNDIGCNGVEYISGMKQLLFLYIYGTNMYPTELQKISEMKQVTNLNISWN 260
                 79999**************************999999999999999999999999999 PP

  == domain 6  score: 13.9 bits;  conditional E-value: 1.9e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++t+L++s N+  + + +  +++++L+ L+  +  ++t  ++ +s L++L+ L++  N++
  EFC37416.1 251 QVTNLNISWNYVGDEGAKYISDMKQLTKLEVVRSDISTEGAKHISELKQLTDLNIGENNI 310
                 578899999999999999999999999999999999999999999999999999999987 PP

  == domain 7  score: 27.0 bits;  conditional E-value: 1.6e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L + ++ ++  + +  + l++L+ L++++N++    + a+s +++Lr Ld+s+N++
  EFC37416.1 275 QLTKLEVVRSDISTEGAKHISELKQLTDLNIGENNIGGEGAIAISKMNQLRILDISDNNI 334
                 79********************************************************97 PP

  == domain 8  score: 37.1 bits;  conditional E-value: 1.1e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt L++  N++ + +  a +++++L++Ld+s+N++  + ++  s++++L++Ld+s+N
  EFC37416.1 299 QLTDLNIGENNIGGEGAIAISKMNQLRILDISDNNIGGIGAEHVSQMKQLTHLDISHN 356
                 699******************************************************* PP

  == domain 9  score: 29.7 bits;  conditional E-value: 2.3e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 +L++Ld+s+N++ +++ e  +++++L++Ld+s+N++ 
  EFC37416.1 323 QLRILDISDNNIGGIGAEHVSQMKQLTHLDISHNCIG 359
                 799*******************************996 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.5     0.044        79      11      35 ..      25      48 ..      19      52 .. 0.78
   2 !   10.0   0.1   0.00053      0.95       2      36 ..      60      94 ..      59      99 .. 0.80
   3 !   12.1   0.5   0.00012      0.21       2      33 ..      83     116 ..      82     131 .. 0.85
   4 ?    5.8   0.1     0.011        20       2      33 ..     107     140 ..     106     153 .. 0.79
   5 !   21.1   2.1   1.6e-07    0.0003       1      34 [.     154     189 ..     154     201 .. 0.89
   6 !   13.7   0.0   3.6e-05     0.064       2      39 ..     203     243 ..     202     248 .. 0.78
   7 ?    1.2   0.0      0.31   5.5e+02       3      32 ..     252     283 ..     250     289 .. 0.65
   8 ?    5.6   0.3     0.013        23      20      34 ..     295     309 ..     274     313 .. 0.68
   9 !   26.9   0.0   2.5e-09   4.5e-06       2      36 ..     323     358 ..     322     363 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.044
                S---E-S-HHH-TT--EEE-.-S-- CS
       LRR_4 11 NqltdiplleklpnLkeLdLsgNnl 35
                  ++++++   l n + L L +Nn+
  EFC37416.1 25 KSIKKLQGEF-LENIENLRLERNNR 48
                3588888877.9********99986 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00053
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                 L+vL+  n ++ + +   + k+ nL++L++ +N  i
  EFC37416.1 60 GLTVLSAEN-CIGTEGVkhICKMNNLTKLNIERN-EI 94
                699999996.999877765448*********888.44 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 0.00012
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-.S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsg.N 33 
                 nL++L++  N + + +   ++k+++L+eL++ g N
  EFC37416.1  83 NLTKLNIERNEIGEEGAkyISKMKQLTELNV-GwN 116
                 9************988887778********9.534 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.011
                 S--EEE--.SS---E-S-.HHH.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLs.nNqltdipl.lek.lpnLkeLdLsgN 33 
                 +L++L+ + n  + + +  + + l+nL+ L +  +
  EFC37416.1 107 QLTELNVGwN-GIGKEGVeFISeLKNLTLLEIEAC 140
                 7999999966.999877785555*******99766 PP

  == domain 5  score: 21.1 bits;  conditional E-value: 1.6e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++L++s N+++ +++  l  l++L++L+L ++n
  EFC37416.1 154 KQLTHLNISYNNISNLGSkyLTELKQLTVLTLCDCN 189
                 58****************98889********98873 PP

  == domain 6  score: 13.7 bits;  conditional E-value: 3.6e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-.S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsg.Nnlitdl 39 
                 +L+ Ld+snN +   +   ++++++L  L++ g N ++t l
  EFC37416.1 203 QLTDLDISNNDIGCNGVeyISGMKQLLFLYIYGtNMYPTEL 243
                 599**********999976558*********6635455555 PP

  == domain 7  score: 1.2 bits;  conditional E-value: 0.31
                 --EEE--.SS---E-S-..HHH-TT--EEE-.- CS
       LRR_4   3 LevLdLs.nNqltdipl..leklpnLkeLdLsg 32 
                  ++L++s n  + d +   ++ +++L++L + +
  EFC37416.1 252 VTNLNISwN-YVGDEGAkyISDMKQLTKLEVVR 283
                 567777755.77777776444599999988755 PP

  == domain 8  score: 5.6 bits;  conditional E-value: 0.013
                 HH-TT--EEE-.-S- CS
       LRR_4  20 eklpnLkeLdLsgNn 34 
                 + l++L+ L++ +Nn
  EFC37416.1 295 SELKQLTDLNIGENN 309
                 349********7773 PP

  == domain 9  score: 26.9 bits;  conditional E-value: 2.5e-09
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++Ld+s+N++  i+    +++++L++Ld+s+N  i
  EFC37416.1 323 QLRILDISDNNIGGIGAehVSQMKQLTHLDISHN-CI 358
                 69***************75336*********999.55 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.2      0.86   1.5e+03       2       2 ..      61      61 ..      37      81 .. 0.52
   2 ?    5.9   0.0     0.014        25       1      21 [.      83     103 ..      83     105 .. 0.79
   3 ?    4.1   0.0     0.058     1e+02       1      14 [.     107     120 ..     107     129 .. 0.75
   4 ?    1.8   0.0      0.32   5.8e+02       1      23 []     131     153 ..     131     153 .. 0.89
   5 !   10.4   0.3   0.00047      0.85       1      20 [.     155     174 ..     155     177 .. 0.86
   6 ?    1.4   0.1      0.42   7.5e+02       2      14 ..     180     192 ..     179     201 .. 0.74
   7 ?    5.8   0.0     0.015        27       2      21 ..     204     223 ..     203     225 .. 0.80
   8 ?    1.6   0.0      0.36   6.4e+02       4      17 ..     254     267 ..     251     273 .. 0.75
   9 ?    1.0   0.0       0.6   1.1e+03       2      17 ..     300     315 ..     299     321 .. 0.73
  10 !    9.9   0.0   0.00068       1.2       1      20 [.     323     342 ..     323     345 .. 0.87
  11 !    9.5   0.0   0.00097       1.7       1      13 [.     347     359 ..     347     369 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.86
       LRR_1  2 L 2 
                L
  EFC37416.1 61 L 61
                3 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++L++++n ++  ++ +++
  EFC37416.1  83 NLTKLNIERNEIGEEGAKYIS 103
                 8*********99776666655 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.058
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++L++++n ++ 
  EFC37416.1 107 QLTELNVGWNGIGK 120
                 599*******9854 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.32
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ L ++ +++ + ++ s++ L
  EFC37416.1 131 NLTLLEIEACRICDEGAKSISEL 153
                 899*********99999998865 PP

  == domain 5  score: 10.4 bits;  conditional E-value: 0.00047
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+hL++s+n++++l++ ++
  EFC37416.1 155 QLTHLNISYNNISNLGSKYL 174
                 59**********99999876 PP

  == domain 6  score: 1.4 bits;  conditional E-value: 0.42
       LRR_1   2 LrhLdLsnnpllg 14 
                 L++L L++++++ 
  EFC37416.1 180 LTVLTLCDCNISE 192
                 99*******9843 PP

  == domain 7  score: 5.8 bits;  conditional E-value: 0.015
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ Ld+snn +++ + ++++
  EFC37416.1 204 LTDLDISNNDIGCNGVEYIS 223
                 889*******9887777665 PP

  == domain 8  score: 1.6 bits;  conditional E-value: 0.36
       LRR_1   4 hLdLsnnpllglpp 17 
                  L++s+n  ++ ++
  EFC37416.1 254 NLNISWNYVGDEGA 267
                 59*****9766655 PP

  == domain 9  score: 1.0 bits;  conditional E-value: 0.6
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L+ L+++ n+++g ++
  EFC37416.1 300 LTDLNIGENNIGGEGA 315
                 888***9998877665 PP

  == domain 10  score: 9.9 bits;  conditional E-value: 0.00068
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr Ld+s+n+++g+++++ 
  EFC37416.1 323 QLRILDISDNNIGGIGAEHV 342
                 59**********99998876 PP

  == domain 11  score: 9.5 bits;  conditional E-value: 0.00097
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L+hLd+s+n+++
  EFC37416.1 347 QLTHLDISHNCIG 359
                 59*********84 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       0.5   9.1e+02     105     126 ..      74      95 ..      22     113 .. 0.51
   2 !   17.0   0.9   1.8e-06    0.0032      52     128 ..     116     193 ..     103     209 .. 0.68
   3 ?    1.8   0.1     0.083   1.5e+02      41     126 ..     201     287 ..     198     306 .. 0.57
   4 ?    4.1   0.1     0.016        29      62     102 ..     320     360 ..     295     374 .. 0.60

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.5
       LRR_9 105 dldPlaslkklellsllknpvt 126
                  ++ + ++++l+ l + +n + 
  EFC37416.1  74 GVKHICKMNNLTKLNIERNEIG 95 
                 3344445555555555555443 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 1.8e-06
       LRR_9  52 ndirkldgfPllkrlktlllnnnrivriaeglee...vlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 n i k +g+ ++  lk l l +   +ri ++ ++    l +l++l ++ n++ +l+  + l++lk+l++l+l ++ ++++
  EFC37416.1 116 NGIGK-EGVEFISELKNLTLLEIEACRICDEGAKsisELKQLTHLNISYNNISNLGS-KYLTELKQLTVLTLCDCNISEE 193
                 55554.566666666666665555555555555500055666777788999999999.99***************99865 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.083
       LRR_9  41 ldqfdtidlsdndirkldgfPllkrlktl...llnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 l+q+  +d+s+ndi   +g+ ++  +k l   ++    +  ++ +    + ++++l ++ n + + +  + + ++k+l+ l ++++ ++
  EFC37416.1 201 LNQLTDLDISNNDIG-CNGVEYISGMKQLlflYIYGTNMYPTELQKISEMKQVTNLNISWNYVGDEGA-KYISDMKQLTKLEVVRSDIS 287
                 678888999999985.4555555555544000444444433333333334455555555565655554.56666666666666666655 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.016
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqe 102
                  +++l++l +++n i  i+ +    + +l++l +++n++ +
  EFC37416.1 320 KMNQLRILDISDNNIGGIGAEHVSQMKQLTHLDISHNCIGN 360
                 45556666666666666655555555556666555555544 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.35   6.3e+02     103     121 ..      95     113 ..      93     116 .. 0.92
   2 ?    3.9   0.0     0.025        44     103     124 ..     119     140 ..     116     142 .. 0.90
   3 ?   -0.9   0.0      0.71   1.3e+03     104     122 ..     144     162 ..     139     172 .. 0.82
   4 !    7.1   0.1    0.0025       4.5      86     123 ..     176     211 ..     146     219 .. 0.64
   5 ?    2.2   0.0      0.08   1.4e+02     103     128 ..     263     288 ..     238     296 .. 0.85
   6 ?   -0.8   0.0      0.69   1.2e+03     106     122 ..     338     354 ..     333     363 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.35
     DUF4347 103 geaGeafvekLaqltgadv 121
                 ge+G ++++k++qlt+ +v
  EFC37416.1  95 GEEGAKYISKMKQLTELNV 113
                 689************9998 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.025
     DUF4347 103 geaGeafvekLaqltgadvaAs 124
                 g++G +f+++L++lt  ++ A 
  EFC37416.1 119 GKEGVEFISELKNLTLLEIEAC 140
                 789***************9996 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.71
     DUF4347 104 eaGeafvekLaqltgadva 122
                 ++G + +++L+qlt+ +++
  EFC37416.1 144 DEGAKSISELKQLTHLNIS 162
                 459999********99985 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0025
     DUF4347  86 alsedadillYgCnvAageaGeafvekLaqltgadvaA 123
                 +l++   + l  C+   +e+G +++++L+qlt  d++ 
  EFC37416.1 176 ELKQLTVLTL--CDCNISEEGCKYISELNQLTDLDISN 211
                 2333334444..55555667***************953 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.08
     DUF4347 103 geaGeafvekLaqltgadvaAstdlt 128
                 g++G +++++++qlt+ +v  s+  t
  EFC37416.1 263 GDEGAKYISDMKQLTKLEVVRSDIST 288
                 678***************99887655 PP

  == domain 6  score: -0.8 bits;  conditional E-value: 0.69
     DUF4347 106 GeafvekLaqltgadva 122
                 G + v++++qlt+ d++
  EFC37416.1 338 GAEHVSQMKQLTHLDIS 354
                 8899*********9994 PP

>> PapC_C  PapC C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.022        39      29      52 ..      94     117 ..      86     121 .. 0.91
   2 ?   -2.8   0.0       3.3   5.9e+03      32      58 ..     169     195 ..     165     201 .. 0.72
   3 ?    6.1   0.0    0.0052       9.3      27      51 ..     260     284 ..     248     289 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.022
                 B-CCCEEEEECE-SEEEEEEES-S CS
      PapC_C  29 VgqgGqvylrglpdqgtLtvkwge 52 
                 +g++G  y++ +++  +L+v w++
  EFC37416.1  94 IGEEGAKYISKMKQLTELNVGWNG 117
                 799*******************85 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.3
                 CCEEEEECE-SEEEEEEES-SSTTSEE CS
      PapC_C  32 gGqvylrglpdqgtLtvkwgegssqqC 58 
                  G  yl+ l++   Lt    + s++ C
  EFC37416.1 169 LGSKYLTELKQLTVLTLCDCNISEEGC 195
                 577899999988888766655555555 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0052
                 EEB-CCCEEEEECE-SEEEEEEES- CS
      PapC_C  27 giVgqgGqvylrglpdqgtLtvkwg 51 
                  +Vg++G  y++ +++  +L+v   
  EFC37416.1 260 NYVGDEGAKYISDMKQLTKLEVVRS 284
                 79******************99865 PP

>> DUF836  Glutaredoxin-like domain (DUF836)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       2.8   5.1e+03      30      52 ..      83     107 ..      61     110 .. 0.57
   2 ?   13.9   0.8   3.1e-05     0.056       2      56 ..     132     183 ..     131     207 .. 0.85
   3 ?   -1.2   0.0       1.6   2.9e+03      24      37 ..     274     287 ..     241     304 .. 0.61

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.8
                 EEEEEETTT-CC..CHCCCCTTTTE CS
      DUF836  30 eleviDIakdee..leakYgleipv 52 
                 +l + +I+++e    +akY  + ++
  EFC37416.1  83 NLTKLNIERNEIgeEGAKYISKMKQ 107
                 3555566655554455566555555 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 3.1e-05
                 EEEEE-TT-HHHHHHHHHHHHHCCCTTEEEEEEETTT-CCCHCCCCTTTTEEEEC CS
      DUF836   2 ltLyskpgChlCeqakekLkelkleegleleviDIakdeeleakYgleipvlale 56 
                 ltL+  + C +C++  + ++elk   +l+++  +I +   l++kY  e ++l + 
  EFC37416.1 132 LTLLEIEACRICDEGAKSISELKQLTHLNISYNNISN---LGSKYLTELKQLTVL 183
                 899999**************99988888888888887...********9999875 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.6
                 CCCTTEEEEEEETT CS
      DUF836  24 kleegleleviDIa 37 
                 k   +le+++ DI 
  EFC37416.1 274 KQLTKLEVVRSDIS 287
                 23334556666665 PP

>> RNA_pol_I_TF  RNA polymerase I specific initiation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.65   1.2e+03      20      55 ..      58      92 ..      42      96 .. 0.82
   2 ?    4.1   0.1     0.016        29      15      57 ..     124     166 ..     118     177 .. 0.82
   3 ?    4.5   0.2     0.012        22      18      57 ..     271     310 ..     262     351 .. 0.72
   4 ?    0.2   0.0      0.25   4.6e+02      21      54 ..     322     355 ..     312     363 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.65
  RNA_pol_I_TF 20 skglevlpdskseirsyktkhienltqllhlnilrr 55
                   kgl vl   ++ i  +  khi ++++l  lni r+
    EFC37416.1 58 MKGLTVLS-AENCIGTEGVKHICKMNNLTKLNIERN 92
                  57788888.77888888999*******999999886 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.016
  RNA_pol_I_TF  15 nflikskglevlpdskseirsyktkhienltqllhlnilrrnw 57 
                   +f ++ k l +l+    +i ++  k i++l+ql hlni+ +n 
    EFC37416.1 124 EFISELKNLTLLEIEACRICDEGAKSISELKQLTHLNISYNNI 166
                   5666777777777777788888999*************99885 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.012
  RNA_pol_I_TF  18 ikskglevlpdskseirsyktkhienltqllhlnilrrnw 57 
                   +  k l  l+ + s+i+ +  khi++l+ql  lni ++n 
    EFC37416.1 271 SDMKQLTKLEVVRSDISTEGAKHISELKQLTDLNIGENNI 310
                   555666667777899********************99886 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.25
  RNA_pol_I_TF  21 kglevlpdskseirsyktkhienltqllhlnilr 54 
                   + l +l+ s ++i     +h+++++ql hl i++
    EFC37416.1 322 NQLRILDISDNNIGGIGAEHVSQMKQLTHLDISH 355
                   5666777777777777899**********99976 PP

>> Ribosomal_L12_N  Ribosomal protein L7/L12 dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.6   6.4e+03       5      15 ..      54      64 ..      53      66 .. 0.78
   2 ?    7.0   0.6    0.0027       4.8       4      17 ..     124     137 ..     123     139 .. 0.91
   3 ?    0.1   0.0      0.38   6.8e+02       7      16 ..     175     184 ..     172     187 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.6
                     HHHHHHTSBHH CS
  Ribosomal_L12_N  5 iieaikeltvL 15
                     ii   k+ltvL
       EFC37416.1 54 IIGLMKGLTVL 64
                     6667899***8 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0027
                      HHHHHHHTSBHHHH CS
  Ribosomal_L12_N   4 eiieaikeltvLEl 17 
                      e+i ++k+lt+LE+
       EFC37416.1 124 EFISELKNLTLLEI 137
                      789**********7 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.38
                      HHHHTSBHHH CS
  Ribosomal_L12_N   7 eaikeltvLE 16 
                       ++k+ltvL 
       EFC37416.1 175 TELKQLTVLT 184
                      689*****95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 2234.66
//
Query:       EFC37417.1  [L=312]
Description: hypothetical protein NAEGRDRAFT_81920 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.043   13.9   3.0        3.9    7.7   0.0    3.4  4  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       0.5     9e+03       5      14 ..     109     119 ..     109     119 .. 0.58
   2 ?   -1.5   0.0      0.18   3.2e+03       2      24 ..     155     176 ..     154     178 .. 0.59
   3 ?    5.0   0.0    0.0016        28      11      25 ..     260     274 ..     256     276 .. 0.79
   4 ?    7.7   0.0   0.00022       3.9       7      28 .]     289     311 ..     288     311 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.5
                 EEEEEE.TTTE CS
         NHL   5 hGvavd.snGd 14 
                 h+++v+  nG+
  EFC37417.1 109 HCLRVVnENGH 119
                 56666656765 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.18
                 SSEEEEEEETTTEEEEEECCCTE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhr 24 
                 ++ +G+ v  + ++y  D++n++
  EFC37417.1 155 CNIWGLDVI-GTRVYYLDFNNSS 176
                 566777665.4455556777766 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0016
                 TTTEEEEEECCCTEE CS
         NHL  11 snGdiyVaDsenhrv 25 
                 + G++++aD e+ ++
  EFC37417.1 260 TEGHVVIADLEHLSL 274
                 68*******988766 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.00022
                 EEEE.TTTEEEEEECCCTEEEEE CS
         NHL   7 vavd.snGdiyVaDsenhrvqvF 28 
                 + vd ++G +y++++ ++++ +F
  EFC37417.1 289 IIVDsKTGLLYICNRTTNHILIF 311
                 558889********999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (312 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       577  (0.0321825); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.23s 00:00:00.65 Elapsed: 00:00:00.41
# Mc/sec: 2304.58
//
Query:       EFC37418.1  [L=452]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.4e-46  158.3   0.1      2e-46  157.8   0.1    1.3  1  BCDHK_Adom3  Mitochondrial branched-chain alpha-ketoacid dehy
    2.6e-12   47.3   0.0    5.5e-12   46.2   0.0    1.6  1  HATPase_c    Histidine kinase-, DNA gyrase B-, and HSP90-like
     0.0019   18.0   0.0     0.0039   17.0   0.0    1.5  1  HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like


Domain annotation for each model (and alignments):
>> BCDHK_Adom3  Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  157.8   0.1   3.4e-50     2e-46       2     162 .]     101     270 ..     100     270 .. 0.96

  Alignments for each domain:
  == domain 1  score: 157.8 bits;  conditional E-value: 3.4e-50
  BCDHK_Adom3   2 vslrqlvqfgekpstgtllksaqflreelpirlAhrvkelenlPdglvenpsvkkvkdwYaqsfeellelpkp.eleenekftelLekikkrHddvvt 98 
                  +sl+ +++fg k++++tll+s+ +l+eelp rl +++++l+nlP+gl+ +psv+ v+dwY+ sf++l   +kp ++ee+ +ft++Le + +rH++++ 
   EFC37418.1 101 ISLKMIMNFGMKLNKQTLLTSSDWLKEELPKRLGRQIRQLDNLPKGLNLMPSVRLVRDWYMASFNDLYYSKKPkTFEEELQFTKMLEGVYTRHNPTLI 198
                  89***********99*********************************************************977*********************** PP

  BCDHK_Adom3  99 tlaqGvlelkekrkrk..........qidseiqsFLdrfymsRIgiRmLieqhiaLteqskskkepsdyvGiId 162
                   +a+Gv elk+k+k++          +  se+++ Ld+fy +RIg+RmLi+qh+aL+eq ++  + +dy G+I+
   EFC37418.1 199 SVAKGVNELKSKMKESiylsdanfdlAEFSELHQALDAFYINRIGMRMLIGQHLALHEQLTK--PVKDYSGLIC 270
                  **********8887778899999988999******************************974..7789*****9 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.2   0.0   9.3e-16   5.5e-12       3     108 ..     314     441 ..     312     444 .. 0.75

  Alignments for each domain:
  == domain 1  score: 46.2 bits;  conditional E-value: 9.3e-16
                 HHHHHHHHHHHHHHHHHH....HSTTTEE.EEEEEE....EETEEEEEEEESSSSSTTHHHTGTCS.TTCH............HCSTCHTSTSSSHHHH CS
   HATPase_c   3 ekrLrqiisnlvdNavkf....atkagei.eveika....seddlvisveDnGiGipkedlkklfe.kfsq............ddstkrggggtGlGls 79 
                 +++L+ i+ +l++N++++     +ka+++ +v++      ++++++i+++D G Gip++dl+k+    +++             +++     g G+Gl 
  EFC37418.1 314 PSHLYYIFFELLKNSMRAvvenHQKAKHLpKVRMVIadsaDKEHISIKISDEGMGIPRKDLHKIWSyLYTTanvmddvskieeFSDSHAPLAGLGYGLP 412
                 6789**************9886335555555555444355348*******************66664444466664444454322333347999***** PP

                 HHHHHHHHTTTEEEEEEETTTEEEEEEEE CS
   HATPase_c  80 ivkklvelmgGeiwvesepgrGttftftl 108
                 +++ +++ +gG+++++s +g Gt+ +++l
  EFC37418.1 413 LSRLYAKYWGGDLTIQSLEGYGTDAYIYL 441
                 ************************98876 PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   6.5e-07    0.0039       8      58 ..     322     383 ..     316     411 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 6.5e-07
  HATPase_c_3   8 aelvdNsldAdaen.........vkievnknr.gktgeivieDdGkGmseeelkn.alrlat 58 
                  +el++Ns+ A  en         v  ++ +   +++ +i+i D+G G+++++l + +  l t
   EFC37418.1 322 FELLKNSMRAVVENhqkakhlpkVRMVIADSAdKEHISIKISDEGMGIPRKDLHKiWSYLYT 383
                  7**********************66655554426779****************996655544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (452 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       460  (0.0256568); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2926.05
//
Query:       EFC37419.1  [L=1878]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.9e-67  228.1  29.5    3.3e-36  125.0   4.9    3.7  4  BLM10_mid  Proteasome-substrate-size regulator, mid region
    4.1e-22   77.9   2.1    2.6e-21   75.3   0.4    3.4  3  DUF3437    Domain of unknown function (DUF3437)
    0.00097   19.2   0.1        1.9    9.0   0.0    5.1  4  HEAT       HEAT repeat


Domain annotation for each model (and alignments):
>> BLM10_mid  Proteasome-substrate-size regulator, mid region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.3   4.3   5.9e-38   3.5e-34       1     182 [.     379     555 ..     379     566 .. 0.94
   2 !  125.0   4.9   5.5e-40   3.3e-36     239     524 .]     571     845 ..     567     845 .. 0.90
   3 ?   -1.6   0.6      0.13   7.9e+02     227     280 ..    1556    1606 ..    1502    1615 .. 0.68
   4 ?   -3.5   0.2      0.51   3.1e+03     245     285 ..    1805    1846 ..    1749    1861 .. 0.53

  Alignments for each domain:
  == domain 1  score: 118.3 bits;  conditional E-value: 5.9e-38
   BLM10_mid   1 LekLiksietffHPSnsGswtkplskfvkelikeflkRwneEekkecktpeerrLteeikkefVkiLrtvvllgifskdskvanyaqsaLklLalLePd 99 
                 L++L++si+++++PSn+G+w++pls f++el  +     ++E++      +++  ++++ +e+++i  + +++++fsk+ kv+++a++a+k +++++P+
  EFC37419.1 379 LRRLFQSIDQYYYPSNNGEWSRPLSIFISELFRNVSLN-TKESS------KDLVVSDDTIEELIRIVFPSCKMALFSKSVKVSKNAIQAIKHICFIRPS 470
                 789****************************9886653.34444......46699******************************************** PP

   BLM10_mid 100 lilpkiLeriypsLeglnethRtiasLkalttlarvlvstklyrv..hltplLslllpgIDlNDlekTlntlnfivsvaqfipie 182
                  i++++ e ++ +L++l+e+h+++++L+ l+t++ +l+ +++  v  ++  lL+++l gID+ND +kT+ t++f+ + ++++pi 
  EFC37419.1 471 CIVQELFEIVFHALQTLTEVHQISVALELLNTIIIPLLYHSIPEVkdYMADLLNMALLGIDTNDSQKTSLTISFLNTLFSIMPII 555
                 ******************************************99999**********************************9996 PP

  == domain 2  score: 125.0 bits;  conditional E-value: 5.5e-40
   BLM10_mid 239 FeewvksfldrvftLlenlPeeskkksgklEesvvnklpatldilleslsdelfdlalkkvvdfvsnnvksnavdavaellaalvka..npektlkkll 335
                 ++++  +f++rv++++  ++ +++  ++k  ++v n+l++ +  ++++ls++l + +l+k++ ++ ++ k  av+ ++e+ ++ v+   n + t + + 
  EFC37419.1 571 YQDFALEFVRRVLHVMGEMTTHKE--ESKEQKEVYNHLSKSIVLFFQQLSPNLHKQCLNKIISYLQDEFKPAAVKQIGEIANCSVNYfnNGDDTYDPFG 667
                 7899**************888777..8899999****************************************************97213344666665 PP

   BLM10_mid 336 pllienIreeiengAgsvrttseilprDraLvwnlsiLnevvrnagealLkykdellellklllekcksergyvltsklvhslLltLtktyptesrlvn 434
                  ++ + I + i n  g  +        D ++  ++ +L +vv+  +++ +k+ d+ll++lkl+  + +s+ ++ +++kl++++L++Lt++y++e+r+v+
  EFC37419.1 668 LMMNSLI-SRITNQKGELKD-----LHDNEMDYYVHLLAKVVK-GNNQTFKHCDKLLQILKLTW-NSESKSIVKSSGKLLKNILQSLTTVYILEKRSVP 758
                 5555555.778777776654.....4799999********998.667889*************9.8899999*************************** PP

   BLM10_mid 435 peeekseelkeeh...WGklqedenlkikWhvPseeeidfAvelleeivepalkkleklleeekskkdkewsdelcryllllrlalsGislLf 524
                 p+ ++se+++++h   WG+l++++n++ +WhvP+e e + A  +++++  ++ + +++ +++      ++ +d+l + ll  +++l G+sl++
  EFC37419.1 759 PNVWRSEDFQKNHfkyWGQLYNSKNVDAQWHVPNESELEKATTIFNDYSRECFTTIKNATTN------QVTRDQLLNALLKAKYILKGASLML 845
                 *********************************************************99998......6899*****************9986 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.13
   BLM10_mid  227 eeeaalrsStaaFeewvksfldrvftLlenlPeeskkksgklEesvvnklpatl 280 
                   +++++ +  ++F+++ ++++++   L e   e+s+k + + Ee + ++l++t+
  EFC37419.1 1556 IQNKLIPKLQTEFSKLYQEYTQK---LSEKSAEQSHKTKPSQEEMTFKSLCKTI 1606
                  34556667777888888888876...5678788888888888888888888775 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 0.51
   BLM10_mid  245 sfldrvftLlenlPeeskkksgklEesvv.nklpatldille 285 
                   f+ +v+  l  ++  +k+++++++ +++ +++++t++++++
  EFC37419.1 1805 PFVPQVLVKLSRFSSYQKSEQETVDIQFLsDTIKNTFTQFMK 1846
                  555555544444444444444444444331344444444444 PP

>> DUF3437  Domain of unknown function (DUF3437)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.46   2.8e+03      22      47 ..    1027    1052 ..    1020    1068 .. 0.86
   2 ?   -2.4   0.0       0.8   4.8e+03      38      72 ..    1728    1764 ..    1721    1774 .. 0.73
   3 !   75.3   0.4   4.3e-25   2.6e-21       9      88 .]    1790    1878 .]    1782    1878 .] 0.89

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.46
     DUF3437   22 vPkwlpevleeLaraardpapirktv 47  
                  + k++ +++e+L++  ++ a+i+ ++
  EFC37419.1 1027 FEKFVTPIIETLSNRDSTHAMINGSI 1052
                  67999*********999999998765 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.8
     DUF3437   38 rdpa.pirktvkktlseFkrthqDtWee.dkkkFtee 72  
                  +d++ ++++ + +tl+ F +  +D+  e  +++F+ e
  EFC37419.1 1728 KDKTvEVKDMACNTLAGFIKIASDDRVEiINAHFSAE 1764
                  566668999999******9999987644366666665 PP

  == domain 3  score: 75.3 bits;  conditional E-value: 4.3e-25
     DUF3437    9 lglsAlvlafpydvPkwlpevleeLar.........aardpapirktvkktlseFkrthqDtWeedkkkFteeqledledvllspsYya 88  
                  +glsAl +afpy++P+++p+vl++L+r          + d +  ++t+k+t+++F +th+++Wee+kk+Fte++l +++++l sp Yya
  EFC37419.1 1790 VGLSALAKAFPYSIPPFVPQVLVKLSRfssyqkseqETVDIQFLSDTIKNTFTQFMKTHHEQWEEHKKQFTEDELYTVNQLLYSPVYYA 1878
                  79*************************9998765433334445789******************************************7 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.032   1.9e+02       3      28 ..     440     465 ..     438     467 .. 0.82
   2 ?   -0.8   0.0      0.42   2.5e+03       5      24 ..    1464    1483 ..    1462    1485 .. 0.86
   3 ?   -1.7   0.0      0.85   5.1e+03       1      14 [.    1628    1642 ..    1628    1649 .. 0.81
   4 !    9.0   0.0   0.00031       1.9       2      29 ..    1720    1747 ..    1719    1749 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.032
                 HHHHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   3 PlllkllsDpspeVReaAakaLgala 28 
                 P +  +l ++s +V ++A++a+ +++
  EFC37419.1 440 PSCKMALFSKSVKVSKNAIQAIKHIC 465
                 554445899****************9 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.42
                  HHHHHT-SSHHHHHHHHHHH CS
        HEAT    5 llkllsDpspeVReaAakaL 24  
                  l + ls+p  ++Re  a+++
  EFC37419.1 1464 LFNHLSHPYQQIRELIARNV 1483
                  67899*********999875 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.85
                  HHHHHHHHH.T-SSH CS
        HEAT    1 llPlllkll.sDpsp 14  
                  +lPl+l++  ++++ 
  EFC37419.1 1628 ILPLFLQCFtCSNDT 1642
                  79***9997677765 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00031
                  HHHHHHHHT-SSHHHHHHHHHHHHHHHH CS
        HEAT    2 lPlllkllsDpspeVReaAakaLgalae 29  
                   ++ll ll+D+  eV ++A+++L+ +++
  EFC37419.1 1720 YNHLLLLLKDKTVEVKDMACNTLAGFIK 1747
                  5789999****************99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1878 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1094  (0.0610185); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.99u 0.35s 00:00:01.34 Elapsed: 00:00:00.51
# Mc/sec: 11075.91
//
Query:       EFC37420.1  [L=676]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0002   21.6   2.8     0.0002   21.6   2.8    1.8  2  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0      0.62   1.1e+04      13      23 ..     195     205 ..     183     223 .. 0.62
   2 !   21.6   2.8   1.1e-08    0.0002       5      77 ..     511     580 ..     506     615 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.62
                 HHHHHHHHHTT CS
         RGS  13 slFreFlesef 23 
                  lF+ F+++++
  EFC37420.1 195 YLFQRFVNRNN 205
                 45555555543 PP

  == domain 2  score: 21.6 bits;  conditional E-value: 1.1e-08
                 HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHH CS
         RGS   5 lledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreele 77 
                 l ++++  +lF+e+  +efs en+ F++ + e+k++     +++++k I ++++ + s+ e+ni+ + r +  
  EFC37420.1 511 LSQSSDFFELFQEYASKEFSLENIMFFDIIHEIKTE---YVTVETMKHIEENFMRNYSKYEVNISFSSRRKFY 580
                 44555599**************************99...889999********************99998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (676 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1623  (0.0905237); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.79u 0.32s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 3942.04
//
Query:       EFC37421.1  [L=314]
Description: Hypothetical protein NAEGRDRAFT_74836 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.5  12.6       0.52   10.5   0.0    5.4  5  LRR_6     Leucine Rich repeat
       0.53   10.1  22.1       0.98    9.2   0.3    5.1  4  LRR_8     Leucine rich repeat
       0.55   10.7  34.3        1.5    9.4   0.6    6.4  6  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.5     0.065   3.9e+02       2      23 ..      18      39 ..      17      39 .. 0.79
   2 ?    1.6   0.1     0.062   3.7e+02       3      11 ..      43      51 ..      41      53 .. 0.84
   3 ?   -1.7   0.1      0.69   4.1e+03       4      10 ..      72      78 ..      71      78 .. 0.88
   4 ?    2.9   0.2     0.024   1.4e+02       3      14 ..     130     141 ..     129     142 .. 0.84
   5 ?   10.5   0.0   8.7e-05      0.52       3      23 ..     194     214 ..     192     215 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.065
       LRR_6  2 nthLteLdLsgNdIgDeGaeaL 23
                 ++Lt LdL   +++ eG+ +L
  EFC37421.1 18 LSNLTDLDLYETNLDMEGIDKL 39
                589******8888888887665 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.062
       LRR_6  3 thLteLdLs 11
                 hLt L+++
  EFC37421.1 43 KHLTRLNIQ 51
                6******97 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.69
       LRR_6  4 hLteLdL 10
                +L++L+L
  EFC37421.1 72 KLKSLNL 78
                79***98 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.024
       LRR_6   3 thLteLdLsgNd 14 
                 ++L+ LdLs+ +
  EFC37421.1 130 SNLQILDLSYLC 141
                 79*******865 PP

  == domain 5  score: 10.5 bits;  conditional E-value: 8.7e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++L++LdL+  ++gDe  e++
  EFC37421.1 194 PNLQSLDLRMGQLGDESFEKI 214
                 79**************87766 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   2.4   0.00035       2.1      22      58 ..      16      52 ..      10      54 .. 0.85
   2 ?   -0.8   0.1      0.22   1.3e+03      23      32 ..      69      78 ..      63      79 .. 0.79
   3 ?    2.2   2.6     0.025   1.5e+02      32      57 ..     115     138 ..     102     143 .. 0.66
   4 ?    9.2   0.3   0.00016      0.98      24      57 ..     164     202 ..     145     206 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00035
                TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8 22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58
                ++lsnL+ LdL + +l+    + + +L++L+ L++++
  EFC37421.1 16 SNLSNLTDLDLYETNLDMEGIDKLIQLKHLTRLNIQY 52
                45************999877789*********99975 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.22
                T-TT--EEE- CS
       LRR_8 23 glsnLkvLdL 32
                ++++Lk+L+L
  EFC37421.1 69 NWKKLKSLNL 78
                6788888887 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.025
                 --SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8  32 LsnNllttlspgafsgLpsLrsLdLs 57 
                 +s Nll++l    ++ L++L+ LdLs
  EFC37421.1 115 ISGNLLKHLL--NCEILSNLQILDLS 138
                 4556666654..55566666666666 PP

  == domain 4  score: 9.2 bits;  conditional E-value: 0.00016
                 -TT--EEE--S.....S---GGGGGGGTT--S-.EEE-- CS
       LRR_8  24 lsnLkvLdLsn.....NllttlspgafsgLpsLrsLdLs 57 
                 l+nL++L+L +      +++ + ++ ++ Lp+L+sLdL+
  EFC37421.1 164 LKNLRILKLYQsymdsDCIKLIAERGCQTLPNLQSLDLR 202
                 677777777541111157999****************96 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   1.8   0.00066       3.9      13      34 ..       8      30 ..       6      38 .. 0.78
   2 ?    3.9   0.2     0.013        76      15      30 ..      35      50 ..      29      62 .. 0.80
   3 ?    0.2   0.1      0.19   1.2e+03      22      30 ..      70      78 ..      53      82 .. 0.81
   4 ?    4.2   4.0     0.011        63       1      32 [.     103     139 ..     103     146 .. 0.75
   5 ?    5.3   2.8    0.0048        29       2      30 ..     131     172 ..     130     182 .. 0.77
   6 ?    9.4   0.6   0.00025       1.5       1      29 [.     194     227 ..     179     245 .. 0.63

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00066
                --E-S-HHH.-TT--EEE-.-S- CS
       LRR_4 13 ltdipllek.lpnLkeLdLsgNn 34
                l+d+  +++ l nL+ LdL + n
  EFC37421.1  8 LQDLKIFNSnLSNLTDLDLYETN 30
                7899999955*********6652 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.013
                E-S-HHH-TT--EEE- CS
       LRR_4 15 diplleklpnLkeLdL 30
                 i+ l +l++L+ L++
  EFC37421.1 35 GIDKLIQLKHLTRLNI 50
                5777888********9 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.19
                -TT--EEE- CS
       LRR_4 22 lpnLkeLdL 30
                 ++Lk+L+L
  EFC37421.1 70 WKKLKSLNL 78
                577888887 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.011
                 SS--EEE--SS---E-S-...HH.H.-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdipl...le.k.lpnLkeLdLsg 32 
                 p Le+L L+  q++   l   l+   l nL+ LdLs 
  EFC37421.1 103 PELEKLVLAESQISGNLLkhlLNcEiLSNLQILDLSY 139
                 67999999955888633345544866*********74 PP

  == domain 5  score: 5.3 bits;  conditional E-value: 0.0048
                 S--EEE--S......S.---E-S-.HH....H.-TT--EEE- CS
       LRR_4   2 nLevLdLsn......N.qltdipl.le....k.lpnLkeLdL 30 
                 nL++LdLs       N  +  +++ l+    k l+nL+ L L
  EFC37421.1 131 NLQILDLSYlcfvysNsSIHNLDGvLAiansKcLKNLRILKL 172
                 999999998666666656999999855667877999999999 PP

  == domain 6  score: 9.4 bits;  conditional E-value: 0.00025
                 SS--EEE--.SS---E-S-HH....H.-TT--EEE CS
       LRR_4   1 pnLevLdLs.nNqltdiplle....k.lpnLkeLd 29 
                 pnL++LdL+ + ql d ++ +      + nL+ L 
  EFC37421.1 194 PNLQSLDLRmG-QLGDESFEKimeyEfMQNLELLF 227
                 56666666655.66666663233334466666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (314 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       619  (0.0345251); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1831.78
//
Query:       EFC37422.1  [L=545]
Description: fragmin60 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-44  148.1   0.3      1e-15   57.4   0.0    3.4  3  Gelsolin  Gelsolin repeat
    1.7e-16   60.3   0.0    4.3e-16   59.1   0.0    1.7  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> Gelsolin  Gelsolin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.4   0.0   1.1e-19     1e-15       2      76 .]     225     306 ..     224     306 .. 0.98
   2 !   42.1   0.0   6.6e-15   5.9e-11       2      68 ..     344     409 ..     343     415 .. 0.93
   3 !   45.0   0.0     8e-16   7.2e-12      12      76 .]     475     540 ..     470     540 .. 0.95

  Alignments for each domain:
  == domain 1  score: 57.4 bits;  conditional E-value: 1.1e-19
                 CEEEEEBSSSGGGEETTSEEEEEESS........EEEEEEHTTSHHHHHHHHHHHHHHHHHCTTTTTSEEEEEETTHHHHHHH CS
    Gelsolin   2 svlpkvvklsssslesgdcyLLdngf........tiflWiGkessqeeknfaadlaaeldseerfplpeliredqgkeparFl 76 
                 +++++v+k +++++++gd+y++++++        +i++W+G + s +e + aa+ ++eld + +++ p+  re+qg+e+++Fl
  EFC37422.1 225 FKVVPVPKETYGQFYDGDSYIILHTYkkenalywNIHFWLGLNTSIDEMGVAAYKTVELD-DLLGGSPVEFREVQGNESDEFL 306
                 789*********************************************************.*********************7 PP

  == domain 2  score: 42.1 bits;  conditional E-value: 6.6e-15
                 CEEEEEBSSSGGGEETTSEEEEEESSEEEEEEHTTSHHHHHHHHHHHHHHHHHCTTTTTSEEEEEET CS
    Gelsolin   2 svlpkvvklsssslesgdcyLLdngftiflWiGkessqeeknfaadlaaeldseerfplpeliredq 68 
                 ++++ +v+l  ssl+ gdc+LLd+g ++ lW G+  s  e+ + ++la+ +  +er+++p+li  ++
  EFC37422.1 344 NIKVTEVPLLFSSLNQGDCFLLDAGLKLLLWEGSSCSNMERFKVNQLAQSIQ-SERGEKPVLIIAKD 409
                 7899************************************************.*********98665 PP

  == domain 3  score: 45.0 bits;  conditional E-value: 8e-16
                 GGGEETTSEEEEEESSEEEEEEHTTSHHHHHHHHHHHHHHHH.HCTTTTTSEEEEEETTHHHHHHH CS
    Gelsolin  12 ssslesgdcyLLdngftiflWiGkessqeeknfaadlaaeld.seerfplpeliredqgkeparFl 76 
                  s+l+s+d++++d+g+++f WiGk+ssq e++ a+d+a+ +  ++ ++ ++++ r+ +g+e  +Fl
  EFC37422.1 475 FSDLKSQDAFIVDAGYKVFTWIGKGSSQNERKYANDFAVTYLrNNGKSLRTQISRVSEGNETSTFL 540
                 689***************************************98888***************9997 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.1   0.0   4.8e-20   4.3e-16       2      93 ..      19     115 ..      18     126 .. 0.92

  Alignments for each domain:
  == domain 1  score: 59.1 bits;  conditional E-value: 4.8e-20
                 EEEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESC......HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHT CS
          C2   2 klevtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvWnekftfevae......leeakLeveVfdndrlskddfiGkveiplstlls 93 
                 +le++  +AknLp++d++g+sd +v+ s+ g++ +k++v++ +lnPvW+ ++ + +++        + +L+v+Vfd+d l+k+d+i ++++++++++s
  EFC37422.1  19 HLEIHLRCAKNLPAMDIGGKSDGFVVFSI-GNESVKSTVVEANLNPVWSDRMLLGIPNgdkltsFDQLVLKVQVFDKDLLTKNDLISEFTLSFKEFKS 115
                 699**************************.********9*********************999878899***********************999444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (545 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       487  (0.0271627); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 3079.96
//
Query:       EFC37423.1  [L=2721]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.4e-44  151.2   1.3    2.4e-44  151.2   1.3    4.0  4  VPS13_C    Vacuolar-sorting-associated 13 protein C-terminal
    5.9e-40  137.5  21.6    6.8e-40  137.3   3.1    5.7  6  VPS13      Vacuolar sorting-associated protein 13, N-terminal
    1.6e-31  108.8   0.2    1.6e-31  108.8   0.2    4.0  3  Chorein_N  N-terminal region of Chorein or VPS13
    1.4e-08   34.9   0.1      9e-08   32.4   0.0    2.3  2  ATG_C      Autophagy-related protein C terminal domain
  ------ inclusion threshold ------
        0.1   13.1   4.6       0.17   12.3   0.0    3.6  3  Goodbye    fungal STAND N-terminal Goodbye domain
       0.14   13.0   2.9        2.7    8.8   0.3    3.3  2  DUF4397    Domain of unknown function (DUF4397)


Domain annotation for each model (and alignments):
>> VPS13_C  Vacuolar-sorting-associated 13 protein C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.2       1.4   4.1e+03      21      64 ..     140     177 ..     133     188 .. 0.49
   2 ?   -2.4   0.2       1.2   3.5e+03       8      56 ..    1480    1531 ..    1476    1551 .. 0.72
   3 !  151.2   1.3   8.1e-48   2.4e-44       1     177 [.    2343    2511 ..    2343    2512 .. 0.97
   4 !    5.0   0.6    0.0063        19     104     155 ..    2522    2574 ..    2521    2594 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.4
     VPS13_C  21 sekknkeeslekeqsllslllllnslgvtltniddapikLnale 64 
                 +e++n+++  ek+++  + +  +++l+ t+   ++ +i++n+++
  EFC37423.1 140 TEETNEKN--EKNEKKQEGF--VSRLTETII--NNLQIEINNIH 177
                 33333322..2333444444..555555553..45555555554 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.2
     VPS13_C    8 hlqPiklhlsfslsekknkeesleke....qsllslllllnslgvtltnidda 56  
                   l+Pi+l++s++ +   +++ + +      + ++++ +++++++++l++i++ 
  EFC37423.1 1480 ILHPISLNVSYTDTLIIQTTRAIN-IristSIIHQIRQVMDMFTSELSKIKKT 1531
                  589999999999887777666443.2366677788888888888888888764 PP

  == domain 3  score: 151.2 bits;  conditional E-value: 8.1e-48
     VPS13_C    1 kiYfeklhlqPiklhlsfslsekknkeeslekeqsllslllllnslgvtltniddapikLnalel.envflslesliekikkhYsqqllkqlykilg 96  
                  k++f k++l+P+k++ sf+ +++++ +          +l+++l+s+g+++t+i++a i++  ++l +++f+++++++e++ khY++q+ ++l +i+g
  EFC37423.1 2343 KMFFGKFELNPLKVDASFKVKPSNDLKY---------DLVYILSSYGTKFTHIENAIIRIYDFKLpQSSFVTMQDVMERVGKHYKRQIKYNLLSIIG 2430
                  69*********************99964.........66777***********************9******************************* PP

     VPS13_C   97 sldvlGNPvglfnnissGvkdlfyePiqglvkgpeefgeglakGaksLvkktvfGvadsvskitgsvskglaaltmDeeYq 177 
                  sl+++G P++lf +++sGv+ lfyeP++++++gp+ f+ g+ kG+  +++++v Gv++ +s+itg+v+++l+ +t+D+++ 
  EFC37423.1 2431 SLNTFGSPIQLFGDLASGVTSLFYEPANAITEGPHMFLLGVGKGSVGFISNSVKGVTGFTSTITGTVGNTLSIFTLDRDFV 2511
                  *******************************************************************************97 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.0063
     VPS13_C  104 PvglfnnissGvkdlfyePiqglvkg.peefgeglakGaksLvkktvfGvads 155 
                  P ++f+ i++G++ lf   i g v    + +    ++Ga  L+k +v G+++ 
  EFC37423.1 2522 PANIFQGIGQGMQVLFTGLIDGGVGIiAQPIKGARKEGALGLAKGVVLGIVGI 2574
                  77778888888888887777777766444444445567777777777776654 PP

>> VPS13  Vacuolar sorting-associated protein 13, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.3   3.1   2.3e-43   6.8e-40       1     175 [.     157     328 ..     157     335 .. 0.91
   2 ?   -1.5   0.0       0.6   1.8e+03      85     137 ..     399     486 ..     348     520 .. 0.55
   3 ?    2.9   0.0     0.026        79     120     173 ..    1207    1260 ..    1173    1276 .. 0.83
   4 !    5.1   0.2    0.0057        17      74     131 ..    1437    1491 ..    1393    1530 .. 0.73
   5 ?    0.9   0.1      0.11   3.3e+02     107     156 ..    2162    2216 ..    2120    2235 .. 0.68
   6 ?   -1.6   0.2      0.62   1.9e+03      71     133 ..    2278    2363 ..    2224    2423 .. 0.47

  Alignments for each domain:
  == domain 1  score: 137.3 bits;  conditional E-value: 2.3e-43
       VPS13   1 FlesLiakIldNlqvtiknvHiryeDslsvpgrpfalGitLesLsaqstdenwkptfikgeeseekivyKlvelesLavYwdsdsse..dksledlsle 97 
                 F+++L+++I++Nlq++i+n+H+ryeD+++ +   +++G tLesLs++s+d nw+++f+++   ++k+++K ++l +L+vY++++++e  +   +dl++ 
  EFC37423.1 157 FVSRLTETIINNLQIEINNIHVRYEDDSD-ERFKVVMGATLESLSMSSCDVNWQESFLAT---TAKTFFKKLTLRNLSVYMNNNETElfSLMKNDLDNR 251
                 899************************66.459*************************99...99*****************99855554445678888 PP

       VPS13  98 eleeafessikeksekakrhqYiLkPvsgeaklklnkkgetd..apklkldleldevgltLseeqyrdilklleslsrle 175
                 ++ e +++ i ek+   + + ++L+Pv+ge+ l ++k++  d  +p+++++l+l++v+ tL+e+qyr+i+++l++++++ 
  EFC37423.1 252 KFIEHMRNIIVEKK---NYRRFVLSPVNGELLLCMQKDEALDleRPRISAELRLESVNATLDERQYRNIQSTLDYITQFM 328
                 8*******998876...4689***************999999888******************************99876 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.6
       VPS13  85 s...........sedksledlslee..leeafe...ssikekseka............krhqYiLkP..vsgeaklkln......kkge 137
                 +           + ++++++ ++e+  +++ f    ++i+ ++e++            k  ++iL P  v++ +k+k+n      ++++
  EFC37423.1 399 KlreaayleiqiE-EQKYKQKKKESsyWSKWFGsidKTIEVTEEDRvefsklfgleedKGPSFILPPhfVNFALKVKINtigvklRNAS 486
                 2333333333321.222222222223344444422255544443236677778888778889999994445555555555555444444 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.026
       VPS13  120 iLkPvsgeaklklnkkgetdapklkldlel.devgltLseeqyrdilklleslsr 173 
                  + +P+++ + lk+  k++   p + ld+e+  +v +tL+++qy  +++l++s++ 
  EFC37423.1 1207 VTSPFNVALGLKRVLKKDH-FPSMYLDIEIvPKVLFTLEHAQYLLLFQLIDSFNK 1260
                  6789999999988755555.5*******99899******************9975 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0057
       VPS13   74 lesLavYwdsdssedksledlsleeleeafessikeksekakrhqYiLkPvsgeaklk 131 
                  +++La+ +++++ + +++++++  +l+ +f++  ++ +   +  +YiL+P+s ++ ++
  EFC37423.1 1437 FNQLAFVMRCKQFSMEDIHNFNIHDLDLSFQKNRNKYD---EYTNYILHPISLNVSYT 1491
                  56666667766644677889999999999999886655...5789********99984 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.11
       VPS13  107 ikekseka.......krhqYiLkPvsgeaklklnkkgetd..apklkldleldevgltL 156 
                  +++    +       ++  Y L P +  + l ++kk++t+    +l +d+ + ++g+++
  EFC37423.1 2162 MNK----EtmkkvgdEEIYYTLIPYQQVIILHIHKKKKTEekDYELAVDVTFYSIGISI 2216
                  222....123346778899***************8888883335556666666777665 PP

  == domain 6  score: -1.6 bits;  conditional E-value: 0.62
       VPS13   71 lvelesLavYwdsds................sedksledlsleeleeafessikeks..eka.................krhqYiLkPvsgeaklkl 132 
                   +++e+   Y+++ s                +            ++++f s++k+ +  +++                    ++ L+P++++a +k+
  EFC37423.1 2278 EFTIEKNGNYFETVSvtiremlfssnnifiqK------------MSDVFASAMKQMKavQETklnqflqyfeveesekmFFGKFELNPLKVDASFKV 2362
                  45555555555555544333333222222220............22222222222221111111211111111111111112234444444444444 PP

       VPS13  133 n 133 
                  +
  EFC37423.1 2363 K 2363
                  4 PP

>> Chorein_N  N-terminal region of Chorein or VPS13
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.8   0.2   5.3e-35   1.6e-31       1     115 [.       2     115 ..       2     116 .. 0.97
   2 ?   -4.2   2.9         6   1.8e+04      92     112 ..     135     154 ..     125     156 .. 0.44
   3 ?   -1.7   0.1         1   3.1e+03       6      36 ..     210     240 ..     207     244 .. 0.86

  Alignments for each domain:
  == domain 1  score: 108.8 bits;  conditional E-value: 5.3e-35
   Chorein_N   1 leslvskllnryLgeyvenldrdqlkvslwsGeveLenlkLkkealdklelPfevkegvigklrlkipwsnlkskpvvieiedvyllaeprseseeede 99 
                 +es+v+k+l++ Lg+y+enld+++l+v++w+G+ +L++l +k++ald l+lPf+v++g++g ++++ipw++++++++++ ++d+ l+++pr  + + de
  EFC37423.1   2 FESVVAKVLTATLGDYIENLDKQSLSVGVWNGKFKLTDLIVKRSALDLLDLPFSVVNGTVGLIEADIPWKSISTSSIKVRLSDIMLVVQPRRCE-KIDE 99 
                 89****************************************************************************************9877.9999 PP

   Chorein_N 100 ekeekreqaakkkkLa 115
                  +e+kr++  k++kL 
  EFC37423.1 100 TSERKRQRMVKQRKLT 115
                 99************97 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 6
   Chorein_N  92 seseeedeekeekreqaakkk 112
                 +++ +++ee +ek+e+++kk+
  EFC37423.1 135 TTT-NQTEETNEKNEKNEKKQ 154
                 223.33333344444444443 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1
   Chorein_N   6 skllnryLgeyvenldrdqlkvslwsGeveL 36 
                 +++l++  + ++++l+  +l+v + + e eL
  EFC37423.1 210 ESFLATTAKTFFKKLTLRNLSVYMNNNETEL 240
                 68999999*************9999988887 PP

>> ATG_C  Autophagy-related protein C terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.97   2.9e+03      29      83 ..    2448    2501 ..    2437    2503 .. 0.71
   2 !   32.4   0.0     3e-11     9e-08       4      82 ..    2518    2596 ..    2515    2607 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.97
       ATG_C   29 aaqtilavpsevaeskgakgavkavvravPvavlrPligateavsktlqGvrnql 83  
                    ++++  p +    +g++ ++ +v +     + + + g+t  +s++ + v n+l
  EFC37423.1 2448 GVTSLFYEPANAI-TEGPHMFLLGVGKGSVGFISNSVKGVTGFTSTITGTVGNTL 2501
                  4444454444433.37888888889999999999999999999998888888877 PP

  == domain 2  score: 32.4 bits;  conditional E-value: 3e-11
       ATG_C    4 yasqPedlreGlqqAysslskglksaaqtilavpsevaeskgakgavkavvravPvavlrPligateavsktlqGvrnq 82  
                  ++++P+++ +G+ q+++ l +gl      i+a p++ a+++ga g +k+vv  +  +  +P++g+ +   k +qG+rn 
  EFC37423.1 2518 MERKPANIFQGIGQGMQVLFTGLIDGGVGIIAQPIKGARKEGALGLAKGVVLGIVGIPTKPVVGMIDFSIKQMQGIRNF 2596
                  6799*************************************************************************95 PP

>> Goodbye  fungal STAND N-terminal Goodbye domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   2.2         6   1.8e+04      19      58 ..     125     164 ..     111     170 .. 0.63
   2 ?   -0.3   0.1      0.48   1.4e+03      32      87 ..    2267    2324 ..    2244    2325 .. 0.76
   3 ?   12.3   0.0   5.8e-05      0.17      24      95 ..    2403    2473 ..    2392    2489 .. 0.84

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 6
     Goodbye  19 ealkelssvedllkqieaekdkfeefrekkeklkealkki 58 
                 ++ ++++s    ++q e+ ++k e+ ++k+e + + l+++
  EFC37423.1 125 NEVSNAASQATTTNQTEETNEKNEKNEKKQEGFVSRLTET 164
                 3445555666677777788887777777777776666555 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.48
     Goodbye   32 kqieaekdkfeefr.ekkeklkealkkilspiqllg.giaaqgasmaFgPaslcfnAv 87  
                   +i++++++f ef+ ek  + +e+++ +++ +   + +i  q  s +F++a   ++Av
  EFC37423.1 2267 VNINSSEQSFIEFTiEKNGNYFETVSVTIREMLFSSnNIFIQKMSDVFASAMKQMKAV 2324
                  379999999*****99999999999999987665542688999999999999999987 PP

  == domain 3  score: 12.3 bits;  conditional E-value: 5.8e-05
     Goodbye   24 lssvedllkqieaekdkfeefrekkeklkealkkilspiqllggiaaqgasmaFgPaslcfnA.vsyLikaak 95  
                  + +++d+++++ ++++  ++ + +  ++  +l+++ spiql+g++a+ + s+ + Pa+++     ++L+ ++k
  EFC37423.1 2403 FVTMQDVMERVGKHYK--RQIKYNLLSIIGSLNTFGSPIQLFGDLASGVTSLFYEPANAITEGpHMFLLGVGK 2473
                  5588999999999999..888999999999****************************998642677777776 PP

>> DUF4397  Domain of unknown function (DUF4397)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.3   0.00089       2.7      22     117 ..     699     792 ..     683     798 .. 0.85
   2 ?    2.7   0.2     0.072   2.1e+02       3      90 ..    2627    2710 ..    2626    2713 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00089
     DUF4397  22 kkvlknvaygdvtgylqvpaGqytielnpagn.kikagttvallnvditleagteytvaavgsaaalellvleddstkpaagtarvrfvnlspdapa 117
                 ++++ +v+ + vt+++++     +++ np+g+ k   ++  +++nv+++l +++e++ a ++  ++ +llv++++s+ +++ +     v++ +++ +
  EFC37423.1 699 TPLMVDVNPQVVTQLVRLGDTVSHFTNNPFGSsK---ESILIVNNVQMKLPKQEELSSAHIQLHDDGRLLVFKEESSLAPSHNIYFNTVQFHTETNS 792
                 555678889999999999999999999****955...666678**************9999999999********************9999987766 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.072
     DUF4397    3 vrvvhaspdapsvDvyvngkkvlknvaygdvtgylqvpaGqytielnpagn.k.ikagttvallnvditleagteytvaavgsaaalell 90  
                  +r++h s ++  +++++    + k++a+++   +++  + ++ +++++  + + i   ++v  +nv+i ++++t+y v++  +aa++++l
  EFC37423.1 2627 LRLIHKSQQSIEFNILIP---LGKTLAITNRHLLIPQSTNSNALQVVELNQvEaI---EQVDDDNVKIRVANQTSYCVYLNVEAATVRAL 2710
                  588888988888888766...8899999999999999999999999666664434...4444489999********99998888777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2721 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2089  (0.116515); expected 358.6 (0.02)
Passed bias filter:                      658  (0.0367003); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.56u 0.32s 00:00:01.88 Elapsed: 00:00:00.55
# Mc/sec: 14849.66
//
Query:       EFC37424.1  [L=342]
Description: hypothetical protein NAEGRDRAFT_74843 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       881  (0.0491383); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2186.52
//
Query:       EFC37425.1  [L=523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2525  (0.140833); expected 358.6 (0.02)
Passed bias filter:                      622  (0.0346924); expected 358.6 (0.02)
Passed Vit filter:                        86  (0.0047967); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.80u 0.31s 00:00:01.11 Elapsed: 00:00:00.49
# Mc/sec: 3234.01
//
Query:       EFC37426.1  [L=761]
Description: hypothetical protein NAEGRDRAFT_59759 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.1e-06   26.2   0.5    2.4e-05   24.5   0.0    2.2  2  NTP_transf_2  Nucleotidyltransferase domain
    2.3e-05   24.4   0.2    9.3e-05   22.4   0.2    2.0  1  Polbeta       Polymerase beta, Nucleotidyltransferase
    0.00012   21.8   2.7      0.019   14.5   0.0    3.0  3  RlaP          RNA repair pathway DNA polymerase beta family
  ------ inclusion threshold ------
       0.79   10.0   4.4        1.7    8.9   0.2    2.8  2  RGS           Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> NTP_transf_2  Nucleotidyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.5   0.0   5.4e-09   2.4e-05       9      81 ..      37     112 ..      32     156 .. 0.75
   2 ?   -2.3   0.1       1.3   5.8e+03      48      80 ..     361     392 ..     327     403 .. 0.67

  Alignments for each domain:
  == domain 1  score: 24.5 bits;  conditional E-value: 5.4e-09
                   HHHTTTSEEEEEHHHHCTTSCTTSSEEEEEEESTTCHHH........HHHEHHHHHHHHCCCEEECTTEEEEEECEEECCC CS
  NTP_transf_2   9 kelepvakvvlfGSyarGtalkgSDiDllvvlpeevsre........kkeegleklaeiikfleellglevdlvtrekled 81 
                   ++ + +  v ++GS   G+a+++SD+D++++ +e  + e        +    ++ +   +  + +++g +vd+++++++ +
    EFC37426.1  37 QQDD-ILLVGVYGSHIYGLATEQSDLDIFIIASEGLDGElaklreliP----NKQDYSYQVTELQINGKQVDFSIYSEKLF 112
                   4444.78899*************************8777999864331....44555566666667888888886555544 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.3
                   HHHEHHHHHHHHCCCEEECTTEEEEEECEEECC CS
  NTP_transf_2  48 kkeegleklaeiikfleellglevdlvtrekle 80 
                   +k +++e la i +f++e    +  ++++++le
    EFC37426.1 361 QKLVKQELLAIINEFTKE-SEKPSAFILKSSLE 392
                   566777777777777777.77777777777776 PP

>> Polbeta  Polymerase beta, Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.2   2.1e-08   9.3e-05       7      70 ..      36     108 ..      33     127 .. 0.71

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 2.1e-08
                 HHHHHHHHSTTEEEEEE-S------EEEEEEEESS-.........--HHHHHHHHHHHHHH..SSSEEEEEETT CS
     Polbeta   7 lekekeielaylFGSrakgkareeSDiDlavllkek.........ldleeelelaaeledi.klgkkvDlvdln 70 
                 ++++ +i l+ ++GS   g a+e+SD+D++++ +e          + + ++ +++ ++ ++   gk+vD+ +++
  EFC37426.1  36 VQQD-DILLVGVYGSHIYGLATEQSDLDIFIIASEGldgelaklrELIPNKQDYSYQVTELqINGKQVDFSIYS 108
                 5566.9*****************************966666544433333444555554444456666766665 PP

>> RlaP  RNA repair pathway DNA polymerase beta family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   4.3e-06     0.019       8      76 ..      26     107 ..      13     118 .. 0.66
   2 !    5.8   0.3     0.002         9     103     177 ..     152     222 ..     132     237 .. 0.72
   3 ?   -1.2   0.1      0.28   1.2e+03     169     201 ..     534     566 ..     498     607 .. 0.60

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 4.3e-06
        RlaP   8 eLeeieeeeev...kilyacesGSrawGfpspdsDyDvrfiyiepaewylgl.........ertrdvielpidd.elDlvgw 76 
                 +Le+ e+ + v    il++ + GS+ +G++++ sD+D   i+ e  +  l           + +++v el+i++ ++D +++
  EFC37426.1  26 KLEQYENPRIVqqdDILLVGVYGSHIYGLATEQSDLDIFIIASEGLDGELAKlrelipnkqDYSYQVTELQINGkQVDFSIY 107
                 567777776334449**********************977776655433322255555443333566665555324555555 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.002
        RlaP 103 ledtseleellrlaekvflsrrvahhYlgmakkqlrrylkgeevrlKkylyvlRpllagrwllekgetpPmefes 177
                 +e+     + ++l+ +   sr++ h ++   +k ++++   +   +K++++ lR+++ g ++ +++++  ++f++
  EFC37426.1 152 VENNVVNSAERALNLRKAISRESDHSFVKGKNKIVKEFKVYK--GIKAMFHSLRTVVFGIQIAKHNQV--IDFSK 222
                 444444455556666666666666767666666666664433..59********************96..56655 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.28
        RlaP 169 etpPmefesllaalv..dasleaeieeLlaikkgg 201
                 +++P+ f++l+ +l+   a ++++++ L++  k +
  EFC37426.1 534 KQLPKAFNKLKSTLTkaAAPIKTKAASLIK--KVT 566
                 456778888888887444444455555543..333 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.5     0.088   3.9e+02      16      82 ..     105     180 ..      97     215 .. 0.71
   2 ?    8.9   0.2   0.00038       1.7      24      84 ..     337     405 ..     329     433 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.088
                 HHHHHHTTCTHHHHHHHHHHHHHTS.........SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCS CS
         RGS  16 reFlesefseenlsFwlaveefkka.........keqeelkkkakeIyneylapsspkelnidkklreelekrlek 82 
                   + e+ f+e  ++F l+  ef +          + +ee+ +++ke +++ + +s+++ ln+ k++  e  + + k
  EFC37426.1 105 SIYSEKLFRELLMRFILDSFEFYSIlmmrrewmvHVNEEFAQQIKEYVENNVVNSAERALNLRKAISRESDHSFVK 180
                 5566666666677777777777777777776777778888888888888888888888888888877666555444 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00038
                 CTHHHHHHHHHHHHHTS.....SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS...S CS
         RGS  24 seenlsFwlaveefkka.....keqeelkkkakeIyneylapsspkelnidkklreelekrleke...q 84 
                 +e  l F  ++ +++k      +eq+ +k++  +I+ne+ ++s + + +i k+  e +++  +k+   q
  EFC37426.1 337 AESLLTFANEIRQMEKLipgsnSEQKLVKQELLAIINEFTKESEKPSAFILKSSLEMVADAKKKKteqQ 405
                 5677777777777777788887888889999*************9999*******99999988874440 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (761 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2940  (0.16398); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                       125  (0.00697194); expected 17.9 (0.001)
Passed Fwd filter:                        51  (0.00284455); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.41u 0.38s 00:00:01.79 Elapsed: 00:00:00.62
# Mc/sec: 3717.74
//
Query:       EFC37427.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-22   80.3   0.0    7.6e-22   77.7   0.0    1.9  2  adh_short      short chain dehydrogenase
    9.1e-13   48.3   0.0    1.3e-12   47.8   0.0    1.2  1  adh_short_C2   Enoyl-(Acyl carrier protein) reductase
    1.9e-07   31.2   0.0    2.9e-07   30.6   0.0    1.2  1  KR             KR domain
    0.00067   19.2   0.2     0.0016   17.9   0.2    1.6  1  GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.7   0.0   1.7e-25   7.6e-22       1     141 [.       4     147 ..       4     157 .. 0.91
   2 ?    0.2   0.0     0.097   4.4e+02     148     187 ..     173     217 ..     167     221 .. 0.72

  Alignments for each domain:
  == domain 1  score: 77.7 bits;  conditional E-value: 1.7e-25
                 SEEEEESTT.SHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT....TSEEEEEE-TTTSHHHHHHHHHHHHHHH.SSESEEEE---SS--SSG CS
   adh_short   1 kvvlvtGas.sGIGraiakelakeGakvvvvdrseekleevakelkee....gakalaiqvDvtdreevealvekavkkl.gkldvLvnNAGitgsgpf 93 
                 k+vl+tG + +GI +++++ l++ Ga vv++ r+ +  ee+  el +e    +++a+++++D++d ++ve++ve  + k+  + +vL+nNAG+   +p 
  EFC37427.1   4 KIVLITGVAkGGISYETCRVLLSLGAVVVMTMRNVKSGEETRRELIKEskclEEQAHVLSLDLADLRNVERFVEVFKTKFnSTCHVLINNAGL--YNPL 100
                 79*****66168******************999999998888887666677799**************************999**********..79** PP

                 GGCSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTS CS
   adh_short  94 selseeewervievNltgvflltravlpamlkqssGrIvnvsSvagkv 141
                 ++l+++++e+ + vN  g f lt+++++ ++ +s+ r++ vsS   ++
  EFC37427.1 101 AKLTSDNIESHFGVNHLGHFYLTELLMDVLV-KSKTRVIVVSSKLHEY 147
                 *****************************88.9999*******87665 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.097
                 HHHHHHHHHHHHHHHHHHHHGGGT.....EEEEEEEESSBSSHHH CS
   adh_short 148 aYsAsKaavagltrslakelaptg.....irvnavaPGlvdTdma 187
                  Ys sK+a + + ++l + ++++        +++++PGlv T +a
  EFC37427.1 173 LYSRSKFANILYCKKLDRIFQEKDtsndrACCVSLHPGLVTTSIA 217
                 799999999999999976555544333446677788888888766 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.8   0.0   2.9e-16   1.3e-12       1     138 [.      10     152 ..      10     158 .. 0.91

  Alignments for each domain:
  == domain 1  score: 47.8 bits;  conditional E-value: 2.9e-16
                   TTT.TSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTT...SE..EEE--TTSHHHHHHHHHHHHHHH.SSEEEEEE-----EGCSS-GGG CS
  adh_short_C2   1 Gaa.sgIGraiAkalaeeGaevvltdlneea.kkrveelaeelg...ae..vlecDVtdeeqvealveevvekf.gklDilvnnagiapklkgpfle 89 
                   G+a  gI +++ + l + Ga vv+t +n ++ +++ +el +e +   ++  vl +D +d  +ve++ve  + kf  + ++l+nnag  ++    +++
    EFC37427.1  10 GVAkGGISYETCRVLLSLGAVVVMTMRNVKSgEETRRELIKESKcleEQahVLSLDLADLRNVERFVEVFKTKFnSTCHVLINNAGLYNP----LAK 102
                   89999**************************99999****998777533347**********************999***********99....99* PP

                   H-HHHHHHHHHHHTHHHHHHHHHHHH.HCTSCCEEEEEEEGGGTSBSTTT CS
  adh_short_C2  90 tsreefdraldvnlyslfllakaalp.lmkeggsivnlssvgaervvpny 138
                   ++ ++++  + vn  + f+l++ ++  l+k++ +++ +ss   e ++p+ 
    EFC37427.1 103 LTSDNIESHFGVNHLGHFYLTELLMDvLVKSKTRVIVVSSKLHEYYTPSE 152
                   **************************7777779*****998888777765 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   0.0   6.4e-11   2.9e-07       3     136 ..       6     142 ..       4     150 .. 0.87

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 6.4e-11
                 EEEET.TTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE---------TTT CS
          KR   3 ylitG.GlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvlrdkllee 99 
                 +litG + Gg+  e++r l++ ga  ++ +   ++ +e+ ++li+e + l+ + +v+++D++d  +ve+ +e +k+++ ++ +  i+ Ag+   ++l++
  EFC37427.1   6 VLITGvAKGGISYETCRVLLSLGAVVVMTMRNVKSGEETRRELIKESKCLEEQAHVLSLDLADLRNVERFVEVFKTKFnSTCHVLINNAGLY--NPLAK 102
                 799*95669***************877777666678888899************************************888888999**997..69*** PP

                 --HHHHHHHHTTTTHHHHHHHHHTTT...S--SEEEEEEE CS
          KR 100 mtaedleqvlapKvkGawnLhelled...esldffvlfSS 136
                 +t++++e+ +     G   L ell d   +s   ++++SS
  EFC37427.1 103 LTSDNIESHFGVNHLGHFYLTELLMDvlvKSKTRVIVVSS 142
                 ****************999999998866544444555555 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.2   3.6e-07    0.0016       1     147 [.       7     161 ..       7     195 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 3.6e-07
                    EEETTT.SHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHH......T-SEEEE--S---.. CS
  GDP_Man_Dehyd   1 LiTGia.GfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaev......qpdevynLAAqsh.. 87 
                    LiTG+a G i   +++ Ll+ g  v+ ++r+ +s + +r e ++++  ++lee+ ++ + Dl D +++er ++         ++  +n A+     
     EFC37427.1   7 LITGVAkGGISYETCRVLLSLGAVVVMTMRNVKSGEETRRELIKES--KCLEEQAHVLSLDLADLRNVERFVEVFktkfnsTCHVLINNAGLYNpl 100
                    89**966999999*********************998888777654..478999*************99998754222222456777888875522 PP

                    HHHHTTSHHHHHHHHTHHHHHHHHHHHHCT..TTSEEEEEEEG..GGG-S-SSSSB-TTS-- CS
  GDP_Man_Dehyd  88 VdvsfekPeytaevnvlGtlrLLeairalglekkvrfyqaSts..EvYGkvqevpqtEttpf 147
                     +   ++ e  + vn lG + L e+  ++ +++k+r++ +S+   E Y +++e  +t +  f
     EFC37427.1 101 AKLTSDNIESHFGVNHLGHFYLTELLMDVLVKSKTRVIVVSSKlhEYY-TPSEKLFTTKEEF 161
                    455567788888999999999999999998889999999988532444.4444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       614  (0.0342462); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1832.88
//
Query:       EFC37428.1  [L=388]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   8.8e-101  337.5   8.9   1.1e-100  337.1   8.9    1.1  1  Asp             Eukaryotic aspartyl protease
    7.6e-13   49.1   4.9    1.1e-08   35.6   0.2    2.6  3  TAXi_N          Xylanase inhibitor N-terminal
      8e-05   22.5   0.1    0.00055   19.8   0.0    2.5  3  TAXi_C          Xylanase inhibitor C-terminal
      0.009   16.6   0.0        1.3    9.7   0.0    2.8  2  Asp_protease_2  Aspartyl protease


Domain annotation for each model (and alignments):
>> Asp  Eukaryotic aspartyl protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  337.1   8.9  2.5e-104  1.1e-100       1     314 [.      76     383 ..      76     384 .. 0.97

  Alignments for each domain:
  == domain 1  score: 337.1 bits;  conditional E-value: 2.5e-104
                 EEEEEEEETTTTEEEEEEEETT--SEEEEBTTESTSHCHHTSS-B-GGG-TT-EEEEEEEEEECTTSEEEEEEEEEEEEETTEEEEEEEEEEEEEESSH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         Asp   1 eYfgeisiGtpeqkftvifDTGSsdlWVpsskckkssackshstydpskSstykkngkslsisYGdgsvsGflsqdtvkvggltvknqefgeatkepgs 99 
                 eY+gei+iGtp q+f+v+fDTGSs+lWVps+ ck    c  h  y+++kSsty  ng+s++i+YG+g+v+G+ls dtv vggl +k+q fge t+e++ 
  EFC37428.1  76 EYYGEITIGTPAQTFKVVFDTGSSNLWVPSVACK-DLSCVRHARYNHTKSSTYVPNGQSFNITYGTGAVKGILSSDTVVVGGLAIKGQVFGETTNEYTD 173
                 6********************************9.899************************************************************* PP

                 HHTTSSSSEEEE-S-GGGSCGGSCCHHHHHHHTTSSSSSEEEEEE-S.TTSSEEEEEESSEEGGGEEEEEEEEEESSTSSTEEEEEEEEETTEEE.EEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxx RF
         Asp 100 tflaakfdGiLGlgfkeisveeatpvfdnlvsqglikepvfsvylnr.eeeeggeivfGgvDeskykGsltyvpvtskgywqielesvtvggktv.lcs 196
                 tfl+ak+dGi G +f++i+v+++tpvf+nl++q+l+++++fs+y+++   +  + +++Gg+++++y+Gs+ yvp+ +++yw+i l+++ ++g+   lc 
  EFC37428.1 174 TFLNAKIDGICGFAFPNIAVDGVTPVFNNLMKQRLVDKNIFSFYMSKkAGSGASAMILGGINSKYYTGSFSYVPLIQHNYWSIALDDIAMNGQGQsLCG 272
                 **********************************************977788899***********************************9987669** PP

                 EEEEEEEETTCSSEEEEHHHHHHHHHHHTTEEEETTCEEEEETTGGGGSEEEEEEETTEEEEEEGGGGEEEESSSTTSEEEESE..EECCTSSSEEEEH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxx RF
         Asp 197 sgcqailDtGTsllalptsivekiakaigakksesegeyvvdCdslsslpdisftiggakitvpvselvlkeeeseesqCilgl..vseeegdlwiLGd 293
                  gc ai+DtGTsl+a++ ++++ i+++++     +      dC+++ s+p++sf+igg+++ ++++++v+k ++++++qC+ g+  +   ++  +iLGd
  EFC37428.1 273 FGCMAIVDTGTSLIAGTPDVMQPIINQLNV---AE------DCSNIDSNPNVSFVIGGKQYLLTPRDYVIKITSQGQTQCFPGFqtMDMGTNGFVILGD 362
                 *************************99987...33......7******************************************7777788999***** PP

                 HHHTTEEEEEETTTTEEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxx RF
         Asp 294 vFlrsayvvfdldnnrvglAe 314
                 vF++ +y+vfd++ +rvg+A+
  EFC37428.1 363 VFISTYYTVFDYEGSRVGFAK 383
                 ********************7 PP

>> TAXi_N  Xylanase inhibitor N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.6   0.2   2.4e-12   1.1e-08       1      52 [.      77     128 ..      77     131 .. 0.93
   2 !   15.2   0.3   4.3e-06     0.019      80     178 .]     133     233 ..     129     233 .. 0.78
   3 ?   -3.3   0.0         2   8.8e+03      16      35 ..     277     296 ..     275     316 .. 0.63

  Alignments for each domain:
  == domain 1  score: 35.6 bits;  conditional E-value: 2.4e-12
      TAXi_N   1 YlvsisiGtppqplklvvDtGsdltWvqCkpckacssqkkpvfdpsksstyk 52 
                 Y+ +i iGtp+q++k+v+DtGs+ +Wv   +ck+ s  ++  ++ +kssty 
  EFC37428.1  77 YYGEITIGTPAQTFKVVFDTGSSNLWVPSVACKDLSCVRHARYNHTKSSTYV 128
                 999******************************9888888899999999996 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 4.3e-06
      TAXi_N  80 eyeisygadgssssGvlatdtltlsstdgksvkvpnlvfGCgk..snlgglaagadGilGLGrgk.......lSlvsqlaskg.slgnkFsyCLsssss 168
                 +++i+yg  g  ++G l++dt+ +     ++  ++  vfG ++   ++  l+a+ dGi G+++ +         + + l +++   +n Fs ++s++  
  EFC37428.1 133 SFNITYG-TG-AVKGILSSDTVVV-----GGLAIKGQVFGETTneYTDTFLNAKIDGICGFAFPNiavdgvtP-VFNNLMKQRlVDKNIFSFYMSKKAG 223
                 5788996.55.9************.....899********88875566667789*********9944444422.334444444377899*****99999 PP

      TAXi_N 169 sssgvlffGd 178
                 s+ +++++G+
  EFC37428.1 224 SGASAMILGG 233
                 9999999996 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 2
      TAXi_N  16 lvvDtGsdltWvqCkpckac 35 
                 ++vDtG +l+  + +  +  
  EFC37428.1 277 AIVDTGTSLIAGTPDVMQPI 296
                 68999998876666555554 PP

>> TAXi_C  Xylanase inhibitor C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.99   4.4e+03      44      88 ..      15      57 ..      13      65 .. 0.66
   2 ?   -2.5   0.0      0.84   3.8e+03     144     158 ..      88     102 ..      74     103 .. 0.72
   3 !   19.8   0.0   1.2e-07   0.00055      92     160 ..     312     382 ..     299     383 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.99
                E-HHHHHHHHHHHHHTS-GG...GE---TT-S-EEETTS...... CS
      TAXi_C 44 letdvYralvkafakelaaekvkrvaavkpfelCynsselgstra 88
                l++ +Y+  ++a  k  + +++   +++k  +l y+++ l  t+ 
  EFC37428.1 15 LRKRAYDDARAASVKLSKMRSI--QTQNKLRSLLYSATRLATTKP 57
                5667777777777666666644..467777778888877665554 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.84
                 BTS-EEEETTTTEEE CS
      TAXi_C 144 ednllvFDleksrlg 158
                 + + +vFD+ +s l+
  EFC37428.1  88 QTFKVVFDTGSSNLW 102
                 467899999988875 PP

  == domain 3  score: 19.8 bits;  conditional E-value: 1.2e-07
                 ---EEEEESSS-EEEE-GGGGEEE-S..SSEEEE.-EEE--S--SSSEEE-HHHHBTS-EEEETTTTEEEEE CS
      TAXi_C  92 vPtitlvleggaewtisgenllvkve..ggvvCl.afvesgvagesavviGglqlednllvFDleksrlgFs 160
                  P++++v   g++  ++++++++k++  g++ C+ +f ++++ +++ v++G + +  ++ vFD e sr+gF+
  EFC37428.1 312 NPNVSFVIG-GKQYLLTPRDYVIKITsqGQTQCFpGFQTMDMGTNGFVILGDVFISTYYTVFDYEGSRVGFA 382
                 588999998.7999999999*999995556***7699999*******************************8 PP

>> Asp_protease_2  Aspartyl protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   0.0    0.0003       1.3       8      87 ..      88     185 ..      79     188 .. 0.53
   2 ?    3.8   0.0     0.021        94      10      29 ..     275     294 ..     268     310 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0003
  Asp_protease_2   8 kpvrfllDTGasttlispelaekl..............glkvreseltvrvsgagge.vkarlvrldslklggltlknvpalvld.......lge 80 
                     +++++++DTG+s++ +++ + ++l                 + +    ++++   g+   + +   d++ +ggl +k++ +  +        l++
      EFC37428.1  88 QTFKVVFDTGSSNLWVPSVACKDLscvrharynhtkssTYVPNG----QSFNITYGTgAVKGILSSDTVVVGGLAIKGQVFGETTneytdtfLNA 178
                     689*************9999999966665554433222111111....22222222223444444445555555555554444443333366666 PP

  Asp_protease_2  81 eidglLG 87 
                     +idg+ G
      EFC37428.1 179 KIDGICG 185
                     6666666 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.021
  Asp_protease_2  10 vrfllDTGasttlispelae 29 
                     +++++DTG s +  +p++ +
      EFC37428.1 275 CMAIVDTGTSLIAGTPDVMQ 294
                     689*******9999998865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (388 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       389  (0.0216967); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 2300.05
//
Query:       EFC37429.1  [L=724]
Description: histidine kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-07   31.2   0.0    4.8e-07   30.1   0.0    1.6  1  CHASE4    CHASE4 domain
     0.0026   18.0   0.2      0.016   15.5   0.0    2.4  2  PAS_9     PAS domain
     0.0028   17.7   0.0      0.017   15.1   0.0    2.2  2  PAS_8     PAS domain
  ------ inclusion threshold ------
        1.4    8.9   8.1        7.8    6.5   8.1    2.4  1  DUF4006   Family of unknown function (DUF4006)


Domain annotation for each model (and alignments):
>> CHASE4  CHASE4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.0   1.1e-10   4.8e-07       1     134 [.     130     292 ..     130     294 .. 0.82

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 1.1e-10
      CHASE4   1 alqaeldqlerllkdwavWDdtyafvqdrdpd.......yiesnlgd.etletlgldlvlfldadgklvy....dqengq.............ekllse 74 
                 a+ +++++  +ll +  +W d y+ +++  +d       +++ n+    + + ++ +++l++ ++g+l      ++e+g              +++l++
  EFC37429.1 130 AIYDDFKNALALLASFGNWLDFYNVMDAAYSDgyktfldWVDINYPYgMMRDAIKSNFALIYFKNGTLAAakgfNLETGDiletpaelanlgsDNPLRK 228
                 68899999999*****************77777************997888899***************655556666668888888888777333333 PP

      CHASE4  75 aeees...grsgllkldggpalvaaapI.ltsegegpsrGtlvfgryldeallsrlseltlldl 134
                 ++++s   +   ll+   g +lv+a pI     ++ p++G+l+f+r  +e++ s+++++++ ++
  EFC37429.1 229 DMDKSttrVNGYLLTSKYGALLVSAYPIhFSPLKNNPPNGILIFARIQTEQVTSSIASRAQMCI 292
                 333334525555567788**********8888999*********************99999877 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   3.5e-06     0.016       2      98 ..     500     599 ..     499     604 .. 0.77
   2 ?   -1.2   0.0      0.55   2.5e+03      12      35 ..     641     668 ..     629     705 .. 0.63

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 3.5e-06
       PAS_9   2 dgili.dnpdgrilyaNeaalrllGys..peevlgksitdlfvtdpeanerlraaleqgrkkerevevvlirkngetfwvllta..spvkdddgelvgi 95 
                 +++++ d ++g+++  Ne + + +Gys     v + s+  lf ++p++++ ++++ e    +  ++ + + + ng  ++v +++  + ++  ++ + ++
  EFC37429.1 500 NSVIMvDKTNGEVVGSNEPFYECTGYSesMIKVGNLSVAKLF-NKPSTDQLMDEFKELTL-NSGSKAMSMSTVNGMIIPVIISVqdAKFYKRNKVVSAF 596
                 56666699*****************9988899**********.88888888888887777.89999999999999999988888333333333333335 PP

       PAS_9  96 ivi 98 
                 ++ 
  EFC37429.1 597 VIS 599
                 554 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.55
       PAS_9  12 ril.yaNeaalrllG.ys..peevlgks 35 
                 + + ++Ne  +rl+  +   ++ + g +
  EFC37429.1 641 EFIrKCNENGKRLTMlFVevKNLMAGLN 668
                 5566777777777633112333344444 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.52   2.3e+03      23      33 ..     292     304 ..     264     333 .. 0.61
   2 !   15.1   0.0   3.8e-06     0.017       4      38 ..     492     528 ..     489     556 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.52
       PAS_8  23 ivd..vNqaalel 33 
                 i++  vN+aal+ 
  EFC37429.1 292 ITQfsVNDAALDS 304
                 3337799999975 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 3.8e-06
       PAS_8   4 ralfesspdgiavvd..lgdrivdvNqaalellGys.a 38 
                 +++++s+p+++++vd  +g+ +v  N+ ++e +Gys  
  EFC37429.1 492 KSIMNSLPNSVIMVDktNGE-VVGSNEPFYECTGYSeS 528
                 79*************97777.*************9942 PP

>> DUF4006  Family of unknown function (DUF4006)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   8.1    0.0017       7.8      11      37 ..     386     411 ..     377     450 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0017
     DUF4006  11 lnGitGmliavvLLLsilavLtvlaik 37 
                 l Gi  ++iav LLL+i+++L+++ i+
  EFC37429.1 386 L-GINAFVIAVCLLLAIMIILGIAVIL 411
                 3.9*******************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (724 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1282  (0.0715043); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.76u 0.35s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 4073.38
//
Query:       EFC37430.1  [L=280]
Description: PaiB family negative transcriptional regulator [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.4e-44  150.5   0.1    4.4e-44  150.2   0.1    1.1  1  FMN_bind_2  Putative FMN-binding domain


Domain annotation for each model (and alignments):
>> FMN_bind_2  Putative FMN-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  150.2   0.1   2.4e-48   4.4e-44       2     167 ..      48     235 ..      47     236 .. 0.95

  Alignments for each domain:
  == domain 1  score: 150.2 bits;  conditional E-value: 2.4e-48
                 XXXXXXXX--HCHHHHHHHHS-EEEEEEEETTEEEEEEEE-EE...-TTSSEEEEEEETTSGGGGGT.........TTS-EEEEEEEEEEEE-CCCSST CS
  FMN_bind_2   2 YipkefaeedleelrqlirenplgtLvtaiesglqashiPflldeeekgkgkLrgHlaraNpqakal........eeeeevlvvfqgpdaYvsPswYte 92 
                 ++p++f++e+ e+  ql+++n++g+L+t++ s+l++sh+Pfl+de++ ++ kL++Hla++Np++kal        +++ ++ ++f gp+ Y+sP+w+  
  EFC37430.1  48 FTPHHFKVERDEDSIQLMKDNSFGILLTWKGSELHTSHVPFLMDETNPNSLKLHFHLAKQNPHCKALeefaksptANGWNCKIIFVGPHFYISPKWFLG 146
                 79***********************************************************************9966667******************* PP

                 TS-.....--EEEEEEEEEEEEE.EE---HHHHHHHHHHHHHHHS---.................--S-------HCHHHCTEEEEEEEEE CS
  FMN_bind_2  93 kkett.kvvPTWnYaaVhvyGka.kviedeeelrkqledltdqaEaerkkp..............wkvedapekyiekllkaIvgieieit 167
                   e + k+vPTWn+++Vh+++   +v+++++e++k+++dlt  +E+    +              +++++++eky+e++lkaIvg+ ++++
  EFC37430.1 147 GLEGQkKKVPTWNFTTVHAHCDScQVYNSHDEKNKIVSDLTVFNED--WLMehfrnpvkelddykYDFSKTDEKYTEQMLKAIVGFTLNVK 235
                 999999***************875899*******************..555568889******999999*******************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       689  (0.0384294); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.26s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1685.23
//
Query:       EFC37431.1  [L=650]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (650 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       667  (0.0372023); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.47
# Mc/sec: 4116.83
//
Query:       EFC37432.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-17   64.0   0.0    6.7e-17   61.6   0.0    2.1  1  DUF1152   Protein of unknown function (DUF1152)


Domain annotation for each model (and alignments):
>> DUF1152  Protein of unknown function (DUF1152)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.6   0.0   3.7e-21   6.7e-17       1     281 [.      50     355 ..      50     359 .. 0.78

  Alignments for each domain:
  == domain 1  score: 61.6 bits;  conditional E-value: 3.7e-21
     DUF1152   1 LvlgiGGGGDvvsalvlaellkklgveavlgsvvW.eRlvvDplPGPisleelegveaineavaivnaesrairgarsvlpqlarvakvlneevvlldi 98 
                 L+ g GGG Dv s l l+  +k +g++++l+ ++  +   +D++   i+l + +g +++  + a  +++     +++ +   l +   + n  v+ ++ 
  EFC37432.1  50 LICGCGGGFDVYSGLPLYFDFKAMGKNVYLANLAFtDVSRMDKKTENIELPSYKGKNTLFAVNAESDNHDLEYFPEKYLCEYLKKEHIEENPIVYTFSR 148
                 577888888888888888888888888888888872444568877777777666666644444444444444444444444444444444456899*** PP

     DUF1152  99 kkgveglaealeelaeklgidliigvDvGGDvLAkGdEegLrSPLaDalslAalskleee......svlavaGpGsDG..ELseeelleriseiake.. 187
                 + gv g++e+ e ++++++id++i vD G Dv+ +G+E gL SP  D++s+  +  ++++       ++  +G+G+D    ++   + e+ sei+++  
  EFC37432.1 149 ETGVVGITEGYEIIIKRHDIDMMIIVDGGNDVMMRGNETGLGSPQEDSMSVVGAYGISTSvlpmerRIVTCIGFGVDHyhGVNSCLFFENTSEIITKfd 247
                 ****************************************************9999998888888899*********722567777889****998555 PP

     DUF1152 188 ggllgilgldee.........daellekileeveteAskiplaaakGlrGe.....veiRkgtrkveltplsalvfyldpkavaelsklaklvagtesl 272
                 +g+lg++++ +e         +++   +i++++++  s+  +aa++G++G+     ++ R ++ +  ++p+ ++ ++ +++++a++    k ++ ++s+
  EFC37432.1 248 NGFLGVCSVVREwncfkqfkkSCQYTFNIMKKAPSIVSSCIIAAIEGQYGNyhppeIKSRTSGSTLYINPMMSMYWFYSLNSIANQLLYKKFIETSKSM 346
                 9****99876542221111115667779**********************72222256799999*********************************** PP

     DUF1152 273 eeAeerlne 281
                 e+ ++ l+ 
  EFC37432.1 347 EDLNRGLRT 355
                 **9998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.55
# Mc/sec: 2032.12
//
Query:       EFC37433.1  [L=244]
Description: hypothetical protein NAEGRDRAFT_81931 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.01   16.0   1.9      0.012   15.8   0.7    1.8  2  Jas       TPL-binding domain in jasmonate signalling
       0.96    9.1   9.0        1.8    8.2   9.0    1.6  1  Med4      Vitamin-D-receptor interacting Mediator subunit 4


Domain annotation for each model (and alignments):
>> Jas  TPL-binding domain in jasmonate signalling
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       0.9   8.1e+03      21      38 ..      64      80 ..      56      89 .. 0.53
   2 ?   15.8   0.7   1.3e-06     0.012      15      64 ..     118     167 ..     105     187 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.9
         Jas 21 dgtkvrylgekkkrrlle 38
                +++k++   +k++++lle
  EFC37433.1 64 KQQKLEQQ-KKNHKKLLE 80
                44444444.344444555 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 1.3e-06
         Jas  15 degilvdgtkvrylgekkkrrllegsikrdgIvCsCCgkvlspseFeaHA 64 
                 +e+i  +++ ++ ++e ++ +  ++++k   I Cs C+k ls   F+ H+
  EFC37433.1 118 SEKISFKNQSCQSIKESTQPKKESNNKKDSIIQCSKCNKCLSSKYFKYHS 167
                 56677788999999665666588899999999*****************7 PP

>> Med4  Vitamin-D-receptor interacting Mediator subunit 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   9.0   0.00021       1.8      20      74 ..      67     137 ..      62     207 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00021
        Med4  20 eleehqkneari.lqLraeveslDekikeivksLkeyekeLkavpdqenskld...............tas 74 
                 +le+++kn++++ ++Lr+e + l+++  ++ + + ++e +L+++  ++ +k++               t++
  EFC37433.1  67 KLEQQKKNHKKLlETLRNENNVLETENLTLKGRILQMEFILQQLKGVSSKKSEkisfknqscqsikesTQP 137
                 79******9986268*****************************988888876666777776666665333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2518  (0.140443); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1480.43
//
Query:       EFC37434.1  [L=261]
Description: hypothetical protein NAEGRDRAFT_81932 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      519  (0.0289475); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1760.44
//
Query:       EFC37435.1  [L=201]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-05   24.6   0.1    6.7e-05   23.1   0.1    1.6  2  NAGPA     Phosphodiester glycosidase


Domain annotation for each model (and alignments):
>> NAGPA  Phosphodiester glycosidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.12   2.1e+03      12      77 ..      17      87 ..      15     107 .. 0.53
   2 !   23.1   0.1   3.7e-09   6.7e-05       2      71 ..     114     192 ..     113     197 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.12
       NAGPA 12 fdpksggplglvisdgkilkk...angeeaagalaitkdgklvvslqeldeanvkea.vgag.plLvkngk 77
                f+  + ++   +is+  i+++     ++ + ++++++++  ++   q+l  + ++ + v+++  +L  +g+
  EFC37435.1 17 FESEQFKERSGLISNYLIVTAsknFEKDLQYSHVHLKNESLPFAPNQKLSGNLIRVTsVSSHfHVLAPHGR 87
                55555555555666666666543322555555666666655555555555544444444444345555555 PP

  == domain 2  score: 23.1 bits;  conditional E-value: 3.7e-09
       NAGPA   2 gavaavnGgffdpksggplglvisdgkilkk...angeeaagalaitkdgklvv....slqeldeanvkeavgag..pl 71 
                  +++a+n+gffd  +g +lg vis+gk+l++      ++a g +   k+++ +v    ++++ ++ +++++v+ g  ++
  EFC37435.1 114 DCIVATNAGFFDVANGYCLGKVISNGKVLNDygrVHPNAAFGLIDDGKGNAQYVfgylNQTDYEKLKITQLVQVGnsSM 192
                 799***************************9754334444444444455555558877777777788888887664344 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (201 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       466  (0.0259914); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.38u 0.23s 00:00:00.61 Elapsed: 00:00:00.39
# Mc/sec: 1546.85
//
Query:       EFC37436.1  [L=1711]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-37  130.3   0.0    2.4e-10   40.6   0.0    5.0  4  Peripla_BP_6   Periplasmic binding protein
    5.2e-23   81.6   0.1    2.5e-22   79.4   0.0    2.1  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    3.1e-10   39.7  10.0     0.0031   16.7   1.9    3.8  3  ANF_receptor   Receptor family ligand binding region


Domain annotation for each model (and alignments):
>> Peripla_BP_6  Periplasmic binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.4   0.0   1.3e-11   7.7e-08       5      58 ..      49     103 ..      45     112 .. 0.89
   2 !   40.6   0.0   3.9e-14   2.4e-10      65     217 ..     135     291 ..     127     416 .. 0.69
   3 !   21.8   0.0   2.1e-08   0.00012      80     315 ..     598     857 ..     592     875 .. 0.78
   4 !   28.4   0.0   2.1e-10   1.2e-06      59     211 ..     998    1153 ..     995    1300 .. 0.85

  Alignments for each domain:
  == domain 1  score: 32.4 bits;  conditional E-value: 1.3e-11
                   EEEE-SSSTTHHHHHHHHHHHHHHHHHHHHTTEET.TEEEEEEEEE-TTSHHHHH CS
  Peripla_BP_6   5 GlltplsGpyassgksllagaqaafeeiNaaGGin.GrkielverDdaydpdraa 58 
                   +  +pl+Gp++ +g+++++g+  af+e+Na GG+  G+k++l++ Dday p+ + 
    EFC37436.1  49 AQSAPLTGPSKRLGIEMRDGILTAFNEFNALGGVFgGKKLKLLTLDDAYEPTNTK 103
                   5678**************************99998799*************9765 PP

  == domain 2  score: 40.6 bits;  conditional E-value: 3.9e-14
                   HHCT--SEEEE-BSHHHHHHHHHHHHHHT-EEEESS-HHCC...TTSTTEEESS--HHHHHHHHHHHHHHHTTSCEEEEEEESSHHHHHHHHHH.HH CS
  Peripla_BP_6  65 vdqdgvdalvgplssavaaavaevlakdgvpvigpagltge...kcspyvfslgpsysaqasalveylakelggkkvalvyadyafgregiaal.ka 157
                   v +++ ++l+g +++++++ v + +  +  p+ig +++ g+   + +p+++++++sy+++++a+ve+l++   ++++ ++y+++afg++g  ++ + 
    EFC37436.1 135 VKGRKYFGLIGFVGTPTVQNVFTDVLSQVWPLIGSFTGVGWlrtPFYPNIINIRASYDDETAAMVEWLVNVKLIRRISIMYQNDAFGNAGLSGInRS 231
                   556899***************9999999******8888876444889***********************888*********************666 PP

                   HHHCCTEEEEEEEEE-TTHHHHHHHHHHHHTTT-SEEEEESSHHHHHHHHHHHHHTT-SS CS
  Peripla_BP_6 158 aakaaGgevvgeepvplgttdfsaqvlqikaagadavllagtgadlaallkaaaeaGlda 217
                   ++k++ + +  + ++p +t +++ + + i + +++a++l+gt a+l + ++ ++++ +++
    EFC37436.1 232 LVKRLNISLCSSGTFPRNTLQVEDAFNTIGKCNPEAIVLIGTYAPLSKYIRLVKDVAFSP 291
                   78999******************************************9999999988775 PP

  == domain 3  score: 21.8 bits;  conditional E-value: 2.1e-08
                   HHHHHHHHHHHHHT-EEEESS-HH...CCTTSTTEE.ESS--HHHHHHHHHHHHHHHTTSCEEEEEEES.SHHHHHHHHHHHHHHHCCTEEEEEEEE CS
  Peripla_BP_6  80 avaaavaevlakdgvpvigpaglt...gekcspyvf.slgpsysaqasalveylakelggkkvalvyad.yafgregiaalkaaakaaGgevvgeep 171
                   + +  ++ + +  ++p++g+ +++     +++   f ++ ps  +q+ ++++y +k+ g  ++ +vy+  ++ + e+++ lk  + + G+e  ++e 
    EFC37436.1 598 NSTIDIRGYSEFSNIPLFGVRSTNsmvLRNTFVSSFiHVFPSIMDQLGTVIDYSMKN-GENRISIVYSSsNSNSVEVRQLLKSILDSIGIET-DSEV 692
                   5555677777778999999543331223344444333778899999*******9996.99*******8769999*****************6.5666 PP

                   E-TTHHHHHHHHHHHHT..TT-SE.EEEESSHHHHHHHHHHHHHTT.....-SSSCEEEE.CCC-CHHHHHHHHHHHHT.........TEEEEESCS CS
  Peripla_BP_6 172 vplgttdfsaqvlqika..agada.vllagtgadlaallkaaaeaG.....ldakrillv.swsgseedlkalggeaae.........gvlavtpyf 250
                     ++t +++++++q+ +  a++    l+ + ++++ +++ +++++      l +k++ ++ + s+++++++a+    +          ++++  p  
    EFC37436.1 693 DATETISLDSIINQLSSntANPHSiFLTLSNPDQILSIISQIKKTYsnsspLFRKGLSVYlINSLFDSSVEAIFSTPLSlivdenlsvKYVSHLPGS 789
                   666899*********9833566663555569999********9876344445578899987888*********887777677776655555555555 PP

                   TCCCSHHHHHHHHHHHHHHTTGGC-.-HHHHHHHHHHHHHHHHHHCCTH.CCHHHHHHHHHHS-.BEC CS
  Peripla_BP_6 251 pdldnpavrafvaayeaayggappp.sqfaaggyiaadlllealkaags.ltreavraaleslg.fdg 315
                   ++ + +   +f +++  +++  +++ ++++++gyi ++++ + + ++g  l+++++ + + +++ +++
    EFC37436.1 790 YNSTLQVITDFENSMDTYFPSINYRnNTAYLEGYIIGAMISAFIDSSGGnLDAKGLLNYMYTVQqVTS 857
                   5567899**************88864889999***************855**********99988875 PP

  == domain 4  score: 28.4 bits;  conditional E-value: 2.1e-10
                    HHHHHHHHCT--SEEEE-BSHHHHHHHHHHHHH....HT-EEEESS.-HHC.CTTSTTEEESS--HHHHHHHHHHHHHHHTTSCEEEEEEESSHH CS
  Peripla_BP_6   59 eaarrlvdqdgvdalvgplssavaaavaevlak....dgvpvigpa.gltg.ekcspyvfslgpsysaqasalveylakelggkkvalvyadyaf 147 
                    ++++ ++++++v+a+v+++ss+  +a  + + +     + p+++++ +l+  ++ s y++++  s  +++++ + y+++ +g  ++a++y++ ++
    EFC37436.1  998 TKVKNMITRQKVFAFVTGFSSDEDFATIDNIKQilttYDTPMLTTSnSLELrKPFSKYFINMKSSVLDEVASQISYFKN-YG--SIAIIYHNIPY 1089
                    57899******************99999965554444666777766555541455555666666666999999*99655.77..9*******887 PP

                    H.HHHHHHHHHHHHCCTEEEEEEEEE-TTHHHHHHHHHHHHTTT-SEEEEESSHHHHHHHHHHHH CS
  Peripla_BP_6  148 g.regiaalkaaakaaGgevvgeepvplgttdfsaqvlqikaagadavllagtgadlaallkaaa 211 
                      +++i+ ++++++ + + +     ++ g++dfs++  ++++ + + ++l+++ ++ a+++  + 
    EFC37436.1 1090 WtNQSIPLIAEYLEYNSISISLIQGFS-GSSDFSSLGVKLQEGNIQSIVLISGSSMSASFISSLI 1153
                    54999**************99888888.9********************************9886 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.4   0.0   4.1e-26   2.5e-22       3     156 ..    1411    1575 ..    1409    1598 .. 0.84
   2 ?   -1.3   0.0      0.24   1.4e+03     141     177 ..    1626    1665 ..    1624    1671 .. 0.76

  Alignments for each domain:
  == domain 1  score: 79.4 bits;  conditional E-value: 4.1e-26
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.......eekaahaaklaela..Ldmle 87  
                     a+++ +++  F+dI+++t l++++  + + + L+ ++  ++++l+  k+ +vkt Gd+++vv++ p        ++++++ ++a+ +  L+m +
     EFC37436.1 1411 APKTGNICCCFTDIQNSTVLWEKC-EKGMREGLKLHNDVLRNQLNLFKGFEVKTQGDCFYVVFKDPldgidwaMSCQHELMSIAWPSelLQMYD 1503
                     57899*******************.899**************************************9999998556666666655434489999 PP

  Guanylate_cyc   88 aleevavesk....eglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellk 156 
                       +e+++e+k    +g++vr G+h G      + ++  r d++Gnt+n A+r+e+ +++g++ +se+  + l 
     EFC37436.1 1504 CRTEFNNETKeivwNGIRVRMGLHFGYAEKIFD-KVVNRPDYFGNTINAAARIEASTQGGQVLISEDMFSELW 1575
                     99999999955666************9887777.899999**************************9887776 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.24
  Guanylate_cyc  141 kagkiqvseetyellk...eeqfeltergevevkGkgkle 177 
                     k++ i+ se+t +  +   + +++ +++ge+++kG + ++
     EFC37436.1 1626 KGRSIKYSENTESTKSedrKLKYHANDLGEFKLKGLQGMI 1665
                     66778888888877777768899************55554 PP

>> ANF_receptor  Receptor family ligand binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0   0.00044       2.6       7     199 ..      70     287 ..      64     375 .. 0.79
   2 !   16.7   1.9   5.2e-07    0.0031      12     198 ..     544     736 ..     536     741 .. 0.79
   3 !   16.1   3.1   7.7e-07    0.0046      38     224 ..     996    1180 ..     958    1243 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00044
                   HHHHHHHHT-TTSSTTEEEEEEEEE-TT-HHHHHHHHHHHCCC.C.........................EEEEEE-SSH.HHHHHHHHHHCCTT-E CS
  ANF_receptor   7 klAveeinsdpnllpgiklgyeiidtccdfslaleaaldflkg.k.........................vvaviGpsss.svsdavaslanlfkiP 76 
                     A++e+n+ +++ +g kl +  +d+++++++++  ++ +l +                            +++iG ++   v ++   ++++   P
    EFC37436.1  70 LTAFNEFNALGGVFGGKKLKLLTLDDAYEPTNTKVNTNLLLYNiTppntstlnqaifnnsialdevkgrkYFGLIGFVGTpTVQNVFTDVLSQV-WP 165
                   6688888888888888888888888888888888888888887447888888888888888888888888777777666623333333333333.46 PP

                   EEESS---GGGG-TTTTTTEEESS--CHHHHHHHHHHHHHTT.--EEEEEEESSHHHHHHHHHHHH.HHHHTT-EEEEEEEESTCHHHCHHHHHHHH CS
  ANF_receptor  77 visygstspelsdknryptflrtvpsdtsqaqAivdilkhfg.Wkkvaliysdddygesglqalee.eleergicvalkekipessnddevvrkllk 171
                   +i+ ++t      + +yp +++++ s      A+v+ l + +  +++++ y++d+ g+ gl  +     ++ +i +  + ++p   +++  v+   +
    EFC37436.1 166 LIG-SFTGVGWLRTPFYPNIINIRASYDDETAAMVEWLVNVKlIRRISIMYQNDAFGNAGLSGINRsLVKRLNISLCSSGTFP---RNTLQVEDAFN 258
                   663.3344445566789***999999999*******88866637999*******************55666679999999999...77788888888 PP

                   HHTT.T--EEEEEE-HHHHHHHHHHHHHT CS
  ANF_receptor 172 eiks.karvivlfcssedarellkaarrl 199
                    i++ ++ +ivl      ++++++ ++++
    EFC37436.1 259 TIGKcNPEAIVLIGTYAPLSKYIRLVKDV 287
                   88999999999998888877777777766 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 5.2e-07
                   HHHT-TTSSTTEEEEEEEEE-TT-HHHHHHHHHHHCCCCEEEEEE.........-SSHHHHHHHHHHHCCTT-EEEESS---GGGG-TTTTTTEEES CS
  ANF_receptor  12 einsdpnllpgiklgyeiidtccdfslaleaaldflkgkvvaviG.........pssssvsdavaslanlfkiPvisygstspelsdknryptflrt 99 
                   + n  +n+  +i+l    +d+  +  + +    ++++   va++G         +s+  +++ +  +++  +iP++++ st++ +   ++ ++f+ +
    EFC37436.1 544 KRN--SNYTRNIELKTLYHDDSASMLKNVVELKTLHES--VAFVGvsaesinldSSNTNSTIDIRGYSEFSNIPLFGVRSTNSMVLRNTFVSSFIHV 636
                   444..447777777777777777777777777777777..7999999999999888889999999*******************7777888****** PP

                   S--CHHHHHHHHHHHHHTT--EEEEEEESS.HHHHHHHHHHHHHHHHTT-EEEEEEEESTCHHHCHHHHHHHHHHTTT--EEEEEE-HHHHHHHHHH CS
  ANF_receptor 100 vpsdtsqaqAivdilkhfgWkkvaliysdd.dygesglqaleeeleergicvalkekipessnddevvrkllkeikskarvivlfcssedarellka 195
                    ps   q   ++d   + g ++++++ys++ ++  ++ q l+  l++ gi+   +   +e  + d+++++l ++++    +++  ++++ + +++ +
    EFC37436.1 637 FPSIMDQLGTVIDYSMKNGENRISIVYSSSnSNSVEVRQLLKSILDSIGIETDSEVDATETISLDSIINQLSSNTANPHSIFLTLSNPDQILSIISQ 733
                   ******************************766666666666666655555444333333444999*****98777744799999999999999999 PP

                   HHH CS
  ANF_receptor 196 arr 198
                   +++
    EFC37436.1 734 IKK 736
                   986 PP

  == domain 3  score: 16.1 bits;  conditional E-value: 7.7e-07
                    HHHHHHHHHCCCCEEEEEE-SSH....HHHHHHHHHHCCTT-EEEESS---GG.GG-TTTTTTEEESS--CHHHHHHHHHHHHHTT--EEEEEEE CS
  ANF_receptor   38 laleaaldflkgkvvaviGpsss....svsdavaslanlfkiPvisygstspe.lsdknryptflrtvpsdtsqaqAivdilkhfgWkkvaliys 127 
                    l  ++ + + ++kv+a++   ss    ++ d +++++++++ P+++   ts++    k ++++f+++  s   + ++ ++i  + ++ ++a+iy 
    EFC37436.1  996 LETKVKNMITRQKVFAFVTGFSSdedfATIDNIKQILTTYDTPMLT---TSNSlELRKPFSKYFINMKSS--VLDEVASQISYFKNYGSIAIIYH 1085
                    444555555666799998877774322356778999*********5...44443445555599****999..78888888888999********* PP

                    SSHHHHHHHHHHHHHHHHTT.-EEEEEEEESTCHHHCHHHHHHHHHHTTT--EEEEEE-HHHHHHHHHH.HHHTTS-STTEEEEETCHCCCECTT CS
  ANF_receptor  128 dddygesglqaleeeleerg.icvalkekipessnddevvrkllkeikskarvivlfcssedarellka.arrlgltgeeyvwiasdawtsslvl 220 
                    +  y+ +    l  e  e++ i ++l + ++ ss+++++  kl+   + + + ivl + s++  +++   +  +   +++   + s+a+ +++v+
    EFC37436.1 1086 NIPYWTNQSIPLIAEYLEYNsISISLIQGFSGSSDFSSLGVKLQ---EGNIQSIVLISGSSMSASFISSlIMYQTTYTPNIGIL-SEAYNNDFVS 1176
                    **8888877776665555555**********8878888888886...559999**********999998633333333345555.6666666665 PP

                    S-CC CS
  ANF_receptor  221 dkpe 224 
                    ++ +
    EFC37436.1 1177 KTFT 1180
                    5554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1711 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1017  (0.0567237); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.97u 0.35s 00:00:01.31 Elapsed: 00:00:00.49
# Mc/sec: 10546.96
//
Query:       EFC37437.1  [L=333]
Description: hypothetical protein NAEGRDRAFT_59766 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.7e-54  184.3   3.3    3.2e-54  184.0   3.3    1.0  1  Glyco_hydro_cc  Glycosyl hydrolase catalytic core
     0.0036   16.0   0.0     0.0056   15.3   0.0    1.3  1  Glyco_hydro_39  Glycosyl hydrolases family 39


Domain annotation for each model (and alignments):
>> Glyco_hydro_cc  Glycosyl hydrolase catalytic core
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  184.0   3.3   3.5e-58   3.2e-54       8     239 .]      44     279 ..      33     279 .. 0.85

  Alignments for each domain:
  == domain 1  score: 184.0 bits;  conditional E-value: 3.5e-58
  Glyco_hydro_cc   8 asddkllsaksskisWyYnwsskpsselssaalefvPmlwgaksadtdalanvksa.akenskylLgFNePDlksqsnmspeeAaklwkqliqpl 101
                     +++ k+l a+s ++ W Ynw++ + s+  ++  ++vP +wg++s ++ ++++++++ ++   ++lLgFNePDl++qsn++p++A++lw++l+++ 
      EFC37437.1  44 TNSYKDL-AQSLNVAWCYNWGNSAPSTGLPSVTSYVPQIWGSGSINNATMTKLANLnQQGMDNVLLGFNEPDLSEQSNLTPQQAVNLWPKLMET- 136
                     3444444.8999********8765555555557***********9988888888884555668899****************************. PP

  Glyco_hydro_cc 102 rekgvklvsPavaatnseegleWldeFleacs.kdckvdflavHwYkgd..feelkehieelheaynkpiWvTEfalqs......esgdasqeet 187
                        + kl+sPa+ a ++++  +Wl++F++ ++ ++ +vdf+avHwY++    + + ++++e +++y++piWvTEfa  +      + +  +q++ 
      EFC37437.1 137 ---KRKLGSPAM-AGYAPSTDSWLSQFMTLATtSKLQVDFIAVHWYGTPqyGSSFLQMVDETYKKYKLPIWVTEFAAADwsatasKPAPYTQKDA 227
                     ...*********.55668999********9886788**********54445778**********************9999998766677778889 PP

  Glyco_hydro_cc 188 keflnevlawldsqeyVeryawfgfrsevsnvgannaLldenGeltelgsaY 239
                      +f+n +++ l +++yVer++wf+ ++  +     +a+++e+G+lte+g+ Y
      EFC37437.1 228 INFMNVTVRGLLERSYVERFSWFAPINPKDPIMGFSAVFNEDGSLTEVGKLY 279
                     9***********************77888889999***************99 PP

>> Glyco_hydro_39  Glycosyl hydrolases family 39
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   6.2e-07    0.0056     193     251 ..     134     195 ..     110     239 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 6.2e-07
  Glyco_hydro_39 193 vseelkvGGPalct...gldewieeltnFfteelvrlDfislHkkgadssiyileqeeaave 251
                     ++ + k+G Pa+++   + d w+++++   t  + ++Dfi+ H +g+ +  +   q+ ++  
      EFC37437.1 134 METKRKLGSPAMAGyapSTDSWLSQFMTLATTSKLQVDFIAVHWYGTPQYGSSFLQMVDETY 195
                     4566799***987644489***************************9775554444444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       690  (0.0384851); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 2414.42
//
Query:       EFC37438.1  [L=1030]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.5e-25   88.5   5.5    4.5e-25   88.5   5.5    3.1  3  Pkinase        Protein kinase domain
    2.2e-16   60.3   1.1      6e-16   58.9   0.2    2.1  2  CNH            CNH domain
    7.2e-13   48.0   1.5    7.2e-13   48.0   1.5    2.4  1  DUF4116        Domain of unknown function (DUF4116)
    5.9e-08   32.9   1.8    5.9e-08   32.9   1.8    2.5  2  Vps39_1        Vacuolar sorting protein 39 domain 1
    3.3e-07   29.8   4.0    3.5e-07   29.8   0.7    2.5  2  Pkinase_Tyr    Protein tyrosine kinase
     0.0021   17.8   1.9      0.073   12.8   2.3    3.2  2  DivIC          Septum formation initiator
  ------ inclusion threshold ------
      0.024   14.8   5.3      0.096   12.9   5.3    2.1  1  HALZ           Homeobox associated leucine zipper
      0.027   14.1   0.5      0.027   14.1   0.5    2.5  3  RIO1           RIO1 family
      0.072   12.4   0.2       0.16   11.3   0.2    1.5  1  Kdo            Lipopolysaccharide kinase (Kdo/WaaP) family
       0.98    9.5   4.9        1.7    8.8   3.9    2.0  1  TolA_bind_tri  TolA binding protein trimerisation
        1.3    9.2   9.7       0.62   10.2   5.7    2.7  2  bZIP_1         bZIP transcription factor
        4.5    7.8  13.5       0.27   11.7   5.9    3.0  3  ZapB           Cell division protein ZapB
        4.6    7.5  13.6          6    7.1   9.3    3.4  2  Cnn_1N         Centrosomin N-terminal motif 1
        4.8    7.6   9.6       0.71   10.3   4.1    2.6  2  Csm1_N         Csm1 N-terminal domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1       1.2   1.6e+03      37      69 ..     451     484 ..     441     494 .. 0.73
   2 ?   -1.3   0.2       0.9   1.2e+03      32      95 ..     572     638 ..     560     644 .. 0.69
   3 !   88.5   5.5   3.5e-28   4.5e-25       1     196 [.     647     868 ..     647     950 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.2
                 HCHHHH.HHHHHHHHHHHHHS.CTTB--EEEEEEE CS
     Pkinase  37 akkkke.kkvlrEikilkklk.hpnivrlyevfee 69 
                 +++k   k + +E+k  k lk h  iv+++++++ 
  EFC37438.1 451 QNEK-AlKYASQELKGDKILKlHTSIVHVVDFVYL 484
                 2233.247899999999999999999999999875 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.9
                 EECHCHCHHHHHHHHHHHHHHHHHSCTT..B--EEEEEEESSEEEEEEE--TTEB.HHHHHHHHSS- CS
     Pkinase  32 ikkekakkkkekkvlrEikilkklkhpn..ivrlyevfeekdelylvleyvegge.ladllerkgsl 95 
                 i k+++  ++ +++ +E ++++ ++h++  i+ l++  + kd   ++ ey +++   +++l++  ++
  EFC37438.1 572 ITKRSKLVETINDISNEFSFHAYSEHEYssIIYLLYKTNGKDIKSILSEYRNTTGtTHRVLTAAIIF 638
                 3444444444479999***999999764338888888888888899999988654255566555555 PP

  == domain 3  score: 88.5 bits;  conditional E-value: 3.5e-28
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH....HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....H CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke....kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....r 91 
                 y+ l++lG G+ G+V+ka++ e ++++A+K+  +++ + +++    + + + i+   k+    i+++ +    +++ly ++e+ + ++l +++     +
  EFC37438.1 647 YHLLSTLGYGAEGVVFKAFDLELKETFAIKIKFESEYDLDHTkkriEFLKQDIEGKIKCFDCGIIEFGHLK--TKHLYTIMEMGD-ESLRKIIGknniN 742
                 78899*************************87777665444333334444555555555588888887764..699******999.6699999855554 PP

                 HSS--HH...HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.................. CS
     Pkinase  92 kgslsee...eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl.................. 169
                 +++++++   e+ +i+++il +++ +H+++i HrDl p+Ni    ++ +Ki+DF+ ++ +e +++ t  vg   Y+APEv                   
  EFC37438.1 743 QKTMEKShliEILEIFSKILYSVQTIHNHNIAHRDLDPNNIVKV-NDTFKIIDFDQSRVVELGKSITINVGKYSYMAPEVSdntyeeenrqdltydskl 840
                 444554467778899**************************999.999********************************9999999998888888777 PP

                 .TTSCBSHHHHHHHHHHHHHHHHHSS-S CS
     Pkinase 170 .keneyskkvDvWslGvilyelltgkpp 196
                  +++e+s+++D++s+G+i++ellt++p+
  EFC37438.1 841 iQNREVSTSCDIFSMGCIFLELLTNCPL 868
                 777999*****************99876 PP

>> CNH  CNH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.9   0.2   4.7e-19     6e-16     109     267 ..       2     153 ..       1     160 [. 0.83
   2 ?   -1.4   0.0       1.1   1.4e+03     142     167 ..     766     798 ..     718     806 .. 0.66

  Alignments for each domain:
  == domain 1  score: 58.9 bits;  conditional E-value: 4.7e-19
         CNH 109 vvavkskivllewneplkkfkkklrefqvpaevfsisvlkpklcvgvakgFelvnldegaaeslldpednsldfaarkenlkplaviqise.defLlcy 206
                 +va k++i +l+++ + + f k ++e+ +++ev s+++ ++klcvg +k++ l++l+     +l+  +++  d ++r       + + +s  +e  l+ 
  EFC37438.1   2 AVASKKTISILKYDSKESTF-KFIQEVVLSDEVKSLNWSREKLCVGLKKEYSLIDLQ-----KLPIGHQKVMDYVNRV----QQNTFGLSLpNETVLSV 90 
                 6999****************.************************************.....3433333223232222....23445555438****** PP

         CNH 207 defavyvdlqGrrsrdseleWegkPesvaclepyllafhknfieirsvetg....elvqeisgkk 267
                 ++++v+ d+ G + r   ++W+++P+ va+l p+l+a+ + ++e+r ++ +    +lvq i++k+
  EFC37438.1  91 NKIGVFIDSSGSKCR--YITWSEVPNMVAYLNPFLIAVLSAGLEVRILHDQltseTLVQNIPLKD 153
                 ***********7766..*****************************9999866667788888775 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.1
         CNH 142 fsisvl.......kpklcvgvakgFelvnldeg 167
                 ++i+         +p+ +v v+++F+++++d++
  EFC37438.1 766 QTIHNHniahrdlDPNNIVKVNDTFKIIDFDQS 798
                 333333334444455566667777777777765 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.0   1.5   5.7e-16   7.2e-13       2      49 .]     417     464 ..     416     464 .. 0.98

  Alignments for each domain:
  == domain 1  score: 48.0 bits;  conditional E-value: 5.7e-16
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +E+ l ++kkng++l+y++  ++nD+ ivl+A kqn +al+yas eL+
  EFC37438.1 417 KEFLLSILKKNGLSLEYAPICYRNDRKIVLEAFKQNEKALKYASQELK 464
                 8*********************************************97 PP

>> Vps39_1  Vacuolar sorting protein 39 domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       4.6   5.9e+03      76      99 ..     322     344 ..     315     347 .. 0.64
   2 !   32.9   1.8   4.6e-11   5.9e-08       1     102 [.     349     447 ..     349     452 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 4.6
     Vps39_1  76 sslkgeketiiqylqklseedldl 99 
                 + + g +   +qyl +++++ ++ 
  EFC37438.1 322 QRKTGLQA-LVQYLLNIRKDLDKY 344
                 33444444.59***9998776655 PP

  == domain 2  score: 32.9 bits;  conditional E-value: 4.6e-11
     Vps39_1   1 iDTaLlkvYlktkpklvgpLlrleNaCdlkdvee.iLkkekkykeLidlYygkklheeALeLlkeladedeedeedsslkgeketiiqylqklseedld 98 
                 +DT+Llk+++ t++    +++  +N+C+++++   iL   ++++eL+ + ++k lh++  +Llk l +   ++   s lk++    ++y   + ++d +
  EFC37438.1 349 VDTSLLKALVLTNDPRTEEFISQPNHCNISESLSfILCDDQNFRELVLFCKTKDLHAKEQQLLKLLEE---KEFLLSILKKNGLS-LEYAPICYRNDRK 443
                 8****************************99866278999***********************98888...44445555555555.6666666666666 PP

     Vps39_1  99 lile 102
                 ++le
  EFC37438.1 444 IVLE 447
                 6665 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1      0.74   9.5e+02      33     109 ..     398     472 ..     381     488 .. 0.64
   2 !   29.8   0.7   2.7e-10   3.5e-07       3     202 ..     649     866 ..     647     872 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.74
                  EEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--E..EEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHH CS
  Pkinase_Tyr  33 vKtlkeeateeekeelleeakimkklkhpnivkl..lgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfa 109
                   Kt + +a+e++  +llee +++ ++ ++n ++l    +c++ +   iv+e  k+++  k L+   +++l+ +++l++ 
   EFC37438.1 398 CKTKDLHAKEQQLLKLLEEKEFLLSILKKNGLSLeyAPICYR-NDRKIVLEAFKQNE--KALKYA-SQELKGDKILKLH 472
                  577777899999999999999999995555554410445554.44567777666552..444444.4445555555555 PP

  == domain 2  score: 29.8 bits;  conditional E-value: 2.7e-10
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEEST...TSSHHHHHHHHH.HHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT. CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlke...eateeekeelle.eakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk. 95 
                  l ++lG Ga G V+++     + k++  + +K  +e   ++t++ + e+l+ +++   k+    i+++  +  k+++l+ ++e+    +L+k + k+ 
   EFC37438.1 649 LLSTLGYGAEGVVFKAFDL--ELKETFAIKIKFESEydlDHTKK-RIEFLKqDIEGKIKCFDCGIIEFGHL--KTKHLYTIMEMG-DESLRKIIGKNn 740
                  67899*********99887..44444555555443311122222.22333225555555555555555444..45899****965.569999999997 PP

                  ....CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE........ CS
  Pkinase_Tyr  96 ....ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk........ 181
                      + ek +l ++l++  ++   ++ ++++++ Hrdl   N+ ++ n++ ki Df  +r +   +  ++ + +   + +mapE+ +++         
   EFC37438.1 741 inqkTMEKSHLIEILEIFSKILYSVQTIHNHNIAHRDLDPNNI-VKVNDTFKIIDFDQSRVV---ELGKSITINVGKYSYMAPEVSDNTYeeenrqdl 834
                  7555566666777889999*********************998.6889**************...44455666778899******9988778899999 PP

                  ...........EEHHHHHHHHHHHHHHHHTTS CS
  Pkinase_Tyr 182 ...........ftsksDvWsfGvllwEiftlg 202
                             ++++ D++s G +  E++t++
   EFC37438.1 835 tydskliqnreVSTSCDIFSMGCIFLELLTNC 866
                  9999999999999999*********9999976 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.69   8.9e+02      55      75 ..      68      88 ..      65      92 .. 0.79
   2 !   12.8   2.3   5.7e-05     0.073      14      51 ..     986    1023 ..     985    1028 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.69
                XXXXXXXXXXXXXXXXXXXXX CS
       DivIC 55 dyieerARselglvkpgEtvy 75
                dy+ ++  + +gl+ p+Etv 
  EFC37438.1 68 DYVNRVQQNTFGLSLPNETVL 88
                66667777889********95 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 5.7e-05
                  XXXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-X CS
       DivIC   14 kgllaykqlkqeiaalqaelaklkaeneeLeaevkdLk 51  
                  ++ll+y+++ qe   lq++++ l++ene+L+ e+++L+
  EFC37438.1  986 RPLLNYSEMIQENFNLQKDVDMLRKENEKLKLELEELR 1023
                  67899********************************6 PP

>> HALZ  Homeobox associated leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   5.3   7.5e-05     0.096      16      40 ..    1000    1024 ..     998    1030 .] 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 7.5e-05
        HALZ   16 aLksdydsLkkenekLkaelqeLke 40  
                  +L+ d+d L+kenekLk el+eL+ 
  EFC37438.1 1000 NLQKDVDMLRKENEKLKLELEELRR 1024
                  5788899999999999999999974 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.97   1.2e+03      43     122 ..     403     483 ..     396     489 .. 0.63
   2 ?   -2.5   0.1       2.5   3.2e+03       2      33 ..     661     693 ..     660     707 .. 0.59
   3 ?   14.1   0.5   2.1e-05     0.027      87     152 ..     735     798 ..     732     808 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.97
                 -GS-HHHHHHHHHHHHHHHHHHHHHTT--...S--EEEEETTEEEEE--EETTEEGGBHHHCG-HHHHHHHHHHHHHHHHHHH CS
        RIO1  43 sktnprklvklwaekEfrnLkrleeagvp...vPkpielkrhvlvmefigedgvaapklkdveeeeeaeelyeevleemrkly 122
                  + + ++l kl  ekEf  L+ l++ g++   +P  +   r +++  f + ++ a++  ++  + +++ +l+  +++ +  +y
  EFC37438.1 403 LHAKEQQLLKLLEEKEF-LLSILKKNGLSleyAPICYRNDRKIVLEAFKQ-NEKALKYASQELKGDKILKLHTSIVHVVDFVY 483
                 46778889999999999.57888888865222566666666665555544.44444444333356677777777777666666 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2.5
                 EEEEEE.TTTEEEEEEEE-S---SS-HHHHCTT CS
        RIO1   2 Vyhavs.edgkevaiKiyktstteFkkrkkyvs 33 
                 V++a++ e ++ +aiKi   s  + ++ kk+++
  EFC37438.1 661 VFKAFDlELKETFAIKIKFESEYDLDHTKKRIE 693
                 666666334446777777666666666655554 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 2.1e-05
                 --EETTEEGGBHHHCG-HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETTEEEE--GTTE CS
        RIO1  87 figedgvaapklkdveeeeeaeelyeevleemrklykeaglvHaDLSeyNvlvdedkvviIDvsQa 152
                  ig+++++ +++++ +   e+ e++ ++l +++ +  ++++ H DL   N++  +d + iID+ Q+
  EFC37438.1 735 IIGKNNINQKTMEKSH-LIEILEIFSKILYSVQTIH-NHNIAHRDLDPNNIVKVNDTFKIIDFDQS 798
                 6778888888888887.6688999*****9877766.****************************8 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.2   0.00012      0.16     125     170 ..     759     799 ..     742     805 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00012
         Kdo 125 kavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldkar 170
                  ++   ++ +h+ ++ H+dl + ni  + ++    ++ +iD+d++r
  EFC37438.1 759 SKILYSVQTIHNHNIAHRDLDPNNIV-KVND----TFKIIDFDQSR 799
                 566677999***************95.5555....79******997 PP

>> TolA_bind_tri  TolA binding protein trimerisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   3.9    0.0013       1.7      22      58 ..     993    1029 ..     987    1030 .] 0.83

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0013
  TolA_bind_tri   22 elqqqlealqqelreLRGqiEelqyqleqleerQrdl 58  
                     e+ q+  +lq++++ LR ++E+l+ +le+l++  ++l
     EFC37438.1  993 EMIQENFNLQKDVDMLRKENEKLKLELEELRRENKKL 1029
                     7888888899999999999999999999998877765 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       4.4   5.7e+03      34      47 ..     971     984 ..     964     990 .. 0.71
   2 ?   10.2   5.7   0.00048      0.62      30      59 ..    1000    1029 ..     994    1030 .] 0.93

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 4.4
                 HHHHHHHHHHHHHH CS
      bZIP_1  34 rvkaLekeNksLks 47 
                  + a+e+e+k+L++
  EFC37438.1 971 LSMAIENEMKELRE 984
                 45567788887775 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00048
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1   30 eLerrvkaLekeNksLkseleelkkevekL 59  
                  +L++ v+ L keN++Lk eleel+ e++kL
  EFC37438.1 1000 NLQKDVDMLRKENEKLKLELEELRRENKKL 1029
                  89*************************998 PP

>> ZapB  Cell division protein ZapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       3.7   4.8e+03      12      26 ..     574     588 ..     568     590 .. 0.86
   2 ?   -3.0   0.1       8.4   1.1e+04      20      33 ..     968     981 ..     961     986 .. 0.47
   3 ?   11.7   5.9   0.00021      0.27      13      51 ..     991    1029 ..     989    1030 .] 0.94

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 3.7
        ZapB  12 kiqkaidtitlLqme 26 
                 k +k+++ti   ++e
  EFC37438.1 574 KRSKLVETINDISNE 588
                 7799*****999988 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 8.4
        ZapB  20 itlLqmeieeLkee 33 
                 it L+m ie  ++e
  EFC37438.1 968 ITDLSMAIENEMKE 981
                 44444444444443 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 0.00021
        ZapB   13 iqkaidtitlLqmeieeLkeeneelkeenreleeeneql 51  
                  ++++i++   Lq+ ++ L++ene+lk e +el++en++l
  EFC37438.1  991 YSEMIQENFNLQKDVDMLRKENEKLKLELEELRRENKKL 1029
                  789999999****************************98 PP

>> Cnn_1N  Centrosomin N-terminal motif 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.95   1.2e+03      38      58 ..     141     161 ..     132     162 .. 0.82
   2 ?    7.1   9.3    0.0047         6       7      71 ..     959    1024 ..     957    1030 .] 0.71

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.95
      Cnn_1N  38 keellkenielkveveslqke 58 
                   e+l +ni lk+e+  + ++
  EFC37438.1 141 TSETLVQNIPLKDEIIAMSQQ 161
                 5678889*******9999876 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0047
      Cnn_1N    7 eqidkLkKENFdLKLriyfLeerleklse.eqkeellkenielkveveslqkelkekkkllreaek 71  
                  ++i+ Lk E  dL + i    ++l + ++  +  e+++en +l+ +v  l+ke++++k +l+e+ +
  EFC37438.1  959 SVINYLKGEITDLSMAIENEMKELREVRPlLNYSEMIQENFNLQKDVDMLRKENEKLKLELEELRR 1024
                  567888888888888885555556666666677777777888888888888887777777777655 PP

>> Csm1_N  Csm1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1         9   1.1e+04      46      64 ..     565     583 ..     563     588 .. 0.74
   2 ?   10.3   4.1   0.00056      0.71      23      60 ..     992    1029 ..     989    1030 .] 0.92

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 9
      Csm1_N  46 Lkeqlaeleekvkeleerr 64 
                 Lk +++++ +++k  e+ +
  EFC37438.1 565 LKDRIQKITKRSKLVETIN 583
                 8899999999888777655 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00056
      Csm1_N   23 sklvhENsvLsqkletkdqeiesLkeqlaeleekvkel 60  
                  s +++EN+ L+++++   +e e+Lk +l+el+ ++k+l
  EFC37438.1  992 SEMIQENFNLQKDVDMLRKENEKLKLELEELRRENKKL 1029
                  5789***************************9998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1030 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1175  (0.0655363); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.95u 0.32s 00:00:01.27 Elapsed: 00:00:00.52
# Mc/sec: 5943.76
//
Query:       EFC37439.1  [L=690]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-30  105.3 143.0    0.00023   21.5  12.8    8.8  8  EGF_2     EGF-like domain
    1.8e-10   41.1 119.9      0.086   13.5   5.2    9.4  8  hEGF      Human growth factor-like EGF
    3.9e-05   23.8 129.5      0.022   15.1   9.2    8.8  8  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   9.8   6.2e-08   0.00037       1      30 [.     346     370 ..     346     371 .. 0.89
   2 !   17.0  13.1   9.8e-07    0.0059       1      32 []     378     407 ..     378     407 .. 0.87
   3 !   19.5  12.0   1.6e-07   0.00094       6      31 ..     416     440 ..     412     442 .. 0.80
   4 !   16.9  13.9     1e-06    0.0061       1      30 [.     447     473 ..     442     476 .. 0.86
   5 !   21.5  12.8   3.8e-08   0.00023       6      32 .]     485     510 ..     476     510 .. 0.87
   6 !   18.3   9.5   3.8e-07    0.0023       1      30 [.     515     540 ..     515     541 .. 0.93
   7 !   12.1  11.8   3.2e-05      0.19       1      32 []     548     577 ..     543     577 .. 0.79
   8 !   18.6  11.1     3e-07    0.0018       1      30 [.     577     607 ..     577     608 .. 0.89

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 6.2e-08
       EGF_2   1 CsasdeiCgghGtCvnqcGq.CdCdsgyqGk 30 
                 C as   C+++GtCv   Gq C+C++g+ G+
  EFC37439.1 346 CTAS---CSNQGTCV---GQiCSCNDGWLGD 370
                 8888...********...466*********8 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 9.8e-07
       EGF_2   1 Csas.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C+   +  Cg +G+C+ ++ qC+C+ g++G++C
  EFC37439.1 378 CEKVdG--CGLNGHCIGPN-QCECKKGWSGPSC 407
                 555544..********888.************* PP

  == domain 3  score: 19.5 bits;  conditional E-value: 1.6e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGkt 31 
                  +C+ghG+C+ ++  C+C+sg+qG +
  EFC37439.1 416 KNCSGHGKCIGSNY-CECQSGWQGSD 440
                 57********6664.********964 PP

  == domain 4  score: 16.9 bits;  conditional E-value: 1e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C+  + +C+++G+C+ ++ qC+C+sgy G 
  EFC37439.1 447 CE--KITCQNNGQCNGPN-QCECPSGYKGS 473
                 55..569********888.********984 PP

  == domain 5  score: 21.5 bits;  conditional E-value: 3.8e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  +C+ hG+Cv+++  C+C+ g++G++C
  EFC37439.1 485 GNCNSHGSCVAPN-TCKCKEGWSGNDC 510
                 47********999.9************ PP

  == domain 6  score: 18.3 bits;  conditional E-value: 3.8e-07
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 Cs+s   C+++G+C +++ qC C+sgy G 
  EFC37439.1 515 CSPS---CQNGGVCTAPN-QCNCPSGYRGS 540
                 9988...********999.********995 PP

  == domain 7  score: 12.1 bits;  conditional E-value: 3.2e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C++ + +C  +G Cv ++  C+C+ g+ G +C
  EFC37439.1 548 CED-QGNCYLNGECVGPN-TCKCNVGWLGSNC 577
                 444.56788888888666.9************ PP

  == domain 8  score: 18.6 bits;  conditional E-value: 3e-07
       EGF_2   1 Csas..deiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C+++  ++ C+++G+C ++  +C+C++g+ G 
  EFC37439.1 577 CKDPdcQLSCNNRGKCSKPY-ECECEDGWKGI 607
                 787788889*******9888.********996 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   7.7   8.4e-05       0.5       1      22 []     350     367 ..     350     367 .. 0.97
   2 !    6.2   7.6    0.0028        17       1      22 []     384     402 ..     384     402 .. 0.87
   3 !   11.4   8.5   6.8e-05      0.41       1      22 []     418     436 ..     418     436 .. 0.97
   4 !   12.4  12.1   3.3e-05       0.2       1      22 []     452     470 ..     452     470 .. 0.96
   5 !   11.8   5.0     5e-05       0.3       1      22 []     487     505 ..     487     505 .. 0.92
   6 !   11.2  10.2   7.7e-05      0.46       1      22 []     519     537 ..     519     537 .. 0.93
   7 !    7.0   7.7    0.0017       9.9       1      22 []     554     572 ..     554     572 .. 0.89
   8 !   13.5   5.2   1.4e-05     0.086       1      22 []     586     604 ..     586     604 .. 0.97

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 8.4e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+n GtC+    g  C C+ G+
  EFC37439.1 350 CSNQGTCV----GQICSCNDGW 367
                 ********....88*******9 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0028
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C  +G Ci   g ++C+C+ G+
  EFC37439.1 384 CGLNGHCI---GPNQCECKKGW 402
                 66688***...779*******9 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 6.8e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G Ci   g++ C+C +G+
  EFC37439.1 418 CSGHGKCI---GSNYCECQSGW 436
                 ********...9999******* PP

  == domain 4  score: 12.4 bits;  conditional E-value: 3.3e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+n+G+C    g ++C+Cp+Gy
  EFC37439.1 452 CQNNGQCN---GPNQCECPSGY 470
                 ********...779*******9 PP

  == domain 5  score: 11.8 bits;  conditional E-value: 5e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn +G+C+     ++C C+ G+
  EFC37439.1 487 CNSHGSCV---APNTCKCKEGW 505
                 9*******...6679******* PP

  == domain 6  score: 11.2 bits;  conditional E-value: 7.7e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+ngG C+     ++C Cp+Gy
  EFC37439.1 519 CQNGGVCT---APNQCNCPSGY 537
                 ********...667*******9 PP

  == domain 7  score: 7.0 bits;  conditional E-value: 0.0017
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+ +G C+   g ++C C+ G+
  EFC37439.1 554 CYLNGECV---GPNTCKCNVGW 572
                 77788***...7799******* PP

  == domain 8  score: 13.5 bits;  conditional E-value: 1.4e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cnn G C      y+C+C  G+
  EFC37439.1 586 CNNRGKCS---KPYECECEDGW 604
                 ********...88********9 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   6.3    0.0065        39       6      28 ..     350     367 ..     342     371 .. 0.81
   2 ?   -0.3  10.1      0.24   1.4e+03       1      31 [.     378     405 ..     373     406 .. 0.77
   3 !   12.6   8.0   2.1e-05      0.13       1      31 [.     412     439 ..     412     440 .. 0.86
   4 !   10.5  12.8   9.7e-05      0.58       5      31 ..     451     473 ..     442     474 .. 0.83
   5 !   14.4   7.1     6e-06     0.036       1      31 [.     481     508 ..     481     509 .. 0.90
   6 !   10.9  11.6   7.6e-05      0.46       4      31 ..     516     540 ..     510     541 .. 0.80
   7 ?    0.1   8.5      0.18   1.1e+03       1      30 [.     548     574 ..     548     576 .. 0.79
   8 !   15.1   9.2   3.6e-06     0.022       5      32 .]     580     608 ..     577     608 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0065
                 STTT-EEEEETTTEEEEEECTTE CS
         EGF   6 CsngGtCvdtgrggytCiCpeGy 28 
                 Csn+GtC  ++    +C C  G+
  EFC37439.1 350 CSNQGTC-VGQ----ICSCNDGW 367
                 *******.777....9***9998 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.24
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C + + C  +G C     g  +C+C+ G++G+
  EFC37439.1 378 CEKvDGCGLNGHC----IGPNQCECKKGWSGP 405
                 5565557778889....34558********96 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 2.1e-05
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs   +Cs++G+C     g+ +C+C++G++G+
  EFC37439.1 412 CSMaKNCSGHGKC----IGSNYCECQSGWQGS 439
                 888455*******....68889********97 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 9.7e-05
                 TSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 pCsngGtCvdtgrggytCiCpeGytGk 31 
                 +C+n+G C    +g  +C+Cp+Gy+G+
  EFC37439.1 451 TCQNNGQC----NGPNQCECPSGYKGS 473
                 5*******....77789********96 PP

  == domain 5  score: 14.4 bits;  conditional E-value: 6e-06
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   ++C+ +G Cv +     tC+C+eG++G+
  EFC37439.1 481 CELvGNCNSHGSCVAPN----TCKCKEGWSGN 508
                 666678***********....**********7 PP

  == domain 6  score: 10.9 bits;  conditional E-value: 7.6e-05
                 TT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytGk 31 
                  p C+ngG C  +     +C Cp+Gy G+
  EFC37439.1 516 SPsCQNGGVCTAPN----QCNCPSGYRGS 540
                 359*******7777....9********96 PP

  == domain 7  score: 0.1 bits;  conditional E-value: 0.18
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytG 30 
                 C + ++C  +G+Cv +     tC+C +G+ G
  EFC37439.1 548 CEDqGNCYLNGECVGP----NTCKCNVGWLG 574
                 888566*******555....5*******966 PP

  == domain 8  score: 15.1 bits;  conditional E-value: 3.6e-06
                 T.....STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p.....CsngGtCvdtgrggytCiCpeGytGkr 32 
                 p     C+n+G+C    +  y+C+C  G++G++
  EFC37439.1 580 PdcqlsCNNRGKC----SKPYECECEDGWKGIN 608
                 334477*******....689***********86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (690 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       669  (0.0373138); expected 358.6 (0.02)
Passed bias filter:                      219  (0.0122148); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.48
# Mc/sec: 4297.86
//
Query:       EFC37440.1  [L=552]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.2e-21   74.3   0.2    8.4e-20   71.0   0.0    2.4  2  Response_reg  Response regulator receiver domain
    2.4e-17   63.4   0.3    1.2e-16   61.2   0.3    2.2  1  HATPase_c     Histidine kinase-, DNA gyrase B-, and HSP90-lik


Domain annotation for each model (and alignments):
>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0     0.075   6.8e+02       1      20 [.     304     323 ..     304     351 .. 0.78
   2 !   71.0   0.0   9.3e-24   8.4e-20       1     111 [.     439     549 ..     439     550 .. 0.96

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.075
                   EEEESSSHHHHHHHHHHHHH CS
  Response_reg   1 vlivdDdplvrellrqllee 20 
                   ++i +Ddp  +++l++l+++
    EFC37440.1 304 IVILEDDPEYLSILTKLCNQ 323
                   7899*****99999998873 PP

  == domain 2  score: 71.0 bits;  conditional E-value: 9.3e-24
                   EEEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHHHHHH..ESEEEEESSCSSSEHHHHHHHHHHCTTTSEEEEEESSTSHHHHHHHHHCTES CS
  Response_reg   1 vlivdDdplvrellrqlleeegyeevaeaedgkealellkeek..vdlillDinmpgmdGlellkeireedpelpviiltahseeedavealkagad 95 
                   +l+vdD+ ++r+ll+++l+  gy + + a+dg+eal+l+k++   +d+i++D+ mp+m G + +k +re     ++i++ta+   +  +   + g +
    EFC37440.1 439 ILVVDDNAINRKLLKKALNMLGY-SADMASDGSEALDLIKKQPnsYDIIFMDLLMPNMGGKDSCKFMREWGCRSQIIAVTANIW-ASSQSLTQNGFS 533
                   8**********************.***************998888***********************************9996.8889999***** PP

                   EEEESSG-HHHHHHHH CS
  Response_reg  96 dflsKpfdpeeLlkal 111
                    +l Kpf+++++++ l
    EFC37440.1 534 SVLRKPFTIDDIKQVL 549
                   ************9976 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.2   0.3   1.3e-20   1.2e-16       1     110 [.     115     271 ..     115     273 .. 0.78

  Alignments for each domain:
  == domain 1  score: 61.2 bits;  conditional E-value: 1.3e-20
                 EHHHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE..............EE.............TEEEEEEEESSSSSTTHHHT................. CS
   HATPase_c   1 gdekrLrqiisnlvdNavkfatkageieveika..............se.............ddlvisveDnGiGipkedlk................. 55 
                 gd +rL q++ n+v+N+vk+ tk+g++ + ++                e             ++++i  +D+GiGipke+l                  
  EFC37440.1 115 GDHIRLSQVLVNFVSNSVKY-TKKGKVYLDVSMikstdkdfpfndqaIEidlgkeiisgnqlEYIKIVCQDTGIGIPKEELGklckpshtihhtegsgl 212
                 6899****************.999988664444445544444443330033333455566789*******************99999999999999999 PP

                 ......GTCSTTCHHCSTCHTSTSSSHHHHHHHHHHHHTTTEEEEEEETTTEEEEEEEEES CS
   HATPase_c  56 ......klfekfsqddstkrggggtGlGlsivkklvelmgGeiwvesepgrGttftftlpl 110
                       k+  +++   ++++   ++G+Gls++ +++ lm+G++++ese ++Gtt t+++p 
  EFC37440.1 213 nnveyeKVYRHLMG--GQNSFNDRHGIGLSLSLNFIHLMKGKLNIESELDKGTTLTLYIPV 271
                 98777755555555..4444457**********************************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (552 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       548  (0.030565); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 3352.73
//
Query:       EFC37441.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       971  (0.0541581); expected 358.6 (0.02)
Passed bias filter:                      532  (0.0296726); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 2252.23
//
Query:       EFC37442.1  [L=195]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (195 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       759  (0.0423336); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1279.75
//
Query:       EFC37443.1  [L=257]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.013   14.6   5.4       0.72    8.8   0.2    2.3  2  NDC10_II  Centromere DNA-binding protein complex CBF3 subunit


Domain annotation for each model (and alignments):
>> NDC10_II  Centromere DNA-binding protein complex CBF3 subunit, domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.2     4e-05      0.72     186     253 ..      14      81 ..       5      87 .. 0.77
   2 ?    7.4   0.9   0.00011       1.9      12      76 ..     190     254 ..     185     256 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 4e-05
                 --EEEHHHHHHHT-GGG-GGGTTSGGGS-HHHHHHHTT--TT----------........-S---HHHH CS
    NDC10_II 186 lpgvseeeirragrknqeamstaflskiPldfvrilNlkspiesagnkskkqgnfylpr.rieppesLl 253
                   ++s+ +ir+ ++ +  ++ ++  ++iP+ f+  lN++      ++++++ ++  l+r ++    ++l
  EFC37443.1  14 AVSTSNSSIRQCKSSMG-KSTRFVGEDIPRTFEDFLNQRDDSDDDDENNNTIKSSSLKRrEKTSKTNIL 81 
                 56788999999999998.556666899**********99999988888888888888885555555555 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.00011
                 --TTT-TTT-SSHHHHHHHHHHHHHHHHH---HHHHTT-BGGGEEE-...SS-TT-EEEEEEE-- CS
    NDC10_II  12 eteelsekifktsleklrflvdfllghylllryedrsklkLsdLktreltkegptpciplvltkr 76 
                 +++e ++ ++k++  +l  l    l + + l+ ++ +kl+LsdL++ +l++e+   +i +++ ++
  EFC37443.1 190 SQKERENVLLKAKISELEKLQHSTLVSRISLTRDEIRKLNLSDLQILKLNTENTLALIEEIINEK 254
                 5566777899999999*********************************9999999998888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1667  (0.0929779); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 1786.66
//
Query:       EFC37444.1  [L=832]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-12   47.2   1.4      4e-12   45.9   1.4    1.7  1  PI3Ka     Phosphoinositide 3-kinase family, accessory domain 
  ------ inclusion threshold ------
       0.44   10.7   4.5         41    4.6   3.2    3.8  2  LRR_6     Leucine Rich repeat


Domain annotation for each model (and alignments):
>> PI3Ka  Phosphoinositide 3-kinase family, accessory domain (PIK domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.9   1.4   4.5e-16     4e-12      57     158 ..     491     591 ..     457     614 .. 0.76

  Alignments for each domain:
  == domain 1  score: 45.9 bits;  conditional E-value: 4.5e-16
                 SSHHHHHHHHHHHTTSHHTTHHHHTTTTSTTS--..HHHHHHHHHHHHHSHHHHHHHHHHHHHHHHGGSSSSSSHHHHHHHHHHHHSHHHHHHHHHHHH CS
       PI3Ka  57 seesevkealelldsWaeididdaLeLLdskfkd..esvreyavkvLekasdeelllYllQLVqalkyepikdsalaefLlkralknkrlghfffWyLk 153
                 ++      a +++++W++  +++ +eL+    ++   + +    k L++ +de ++++l+ L+q++kye  +++ l+e+L+ r +k+k +g+++fW Lk
  EFC37444.1 491 ETPMVLFRANQIMEKWKK--PNNVMELFTLFSSKigIFSKLTLLKYLDETKDEIFSYILPFLIQCIKYE-NENGLLSEYLITRCIKSKVFGNQLFWLLK 586
                 555555567788999985..555555554332222122233346779999999999999**********.89*************************** PP

                 HHHHC CS
       PI3Ka 154 seied 158
                 se++ 
  EFC37444.1 587 SESHY 591
                 **974 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   3.2    0.0046        41       1      13 [.     191     203 ..     191     207 .. 0.91
   2 ?    2.8   0.0     0.018   1.6e+02       4      14 ..     218     228 ..     217     231 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0046
       LRR_6   1 snthLteLdLsgN 13 
                 ++++Lt+LdLs N
  EFC37444.1 191 NCNNLTKLDLSNN 203
                 699********99 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.018
       LRR_6   4 hLteLdLsgNd 14 
                 +L++L++++N+
  EFC37444.1 218 KLKYLNMKYNK 228
                 8*********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (832 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       847  (0.0472419); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.29s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 5106.33
//
Query:       EFC37445.1  [L=685]
Description: casein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-21   77.4   0.0    2.2e-21   76.4   0.0    1.5  1  Pkinase         Protein kinase domain
    1.1e-12   47.8   0.0    4.3e-11   42.6   0.0    2.2  1  Pkinase_Tyr     Protein tyrosine kinase
    6.7e-08   31.7   0.0    1.2e-07   30.8   0.0    1.6  1  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.4   0.0   3.7e-25   2.2e-21       1     220 [.     338     623 ..     338     648 .. 0.83

  Alignments for each domain:
  == domain 1  score: 76.4 bits;  conditional E-value: 3.7e-25
                 EEEEEEEEEESSEEEEEEEETTTT.EEEEEEEEECHCHCHHHH....HHHHHHHHHHHHHS..CTTB--EEEEEEE......................S CS
     Pkinase   1 yekleklGeGsfGkVykaveketg.kivAvKkikkekakkkke....kkvlrEikilkklk..hpnivrlyevfee......................k 70 
                 y+ ++klG+G+fG+V+ + + e++ + +AvK       ++ +     ++++ E k++  l    pn  +  ++ ++                       
  EFC37445.1 338 YRLMSKLGNGAFGEVFLCQNIEQReEYYAVKLETLPTPQNGQAnsgkQQLIYEAKVISYLMnaQPNSTTSSNSTTNssnnqimsichgiprvfwfgteG 436
                 67789**************987751568***76655555544455779**********9987899999999998889*******************655 PP

                 SEEEEEEE--TTEBHHHHHH.HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET.............................TTEEEE CS
     Pkinase  71 delylvleyveggeladlle.rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide.............................kgelKi 139
                  + ++vle++  ++l++l +  ++++s +++  +a q+++ +ey H+++++HrD+Kp+N+L+ +                             ++ + +
  EFC37445.1 437 VYNIMVLELLG-QSLESLFKkCSRKFSLKTVLMLADQMIQRIEYTHKRNFVHRDIKPDNFLMGRkvpgnsptgllnllnapyqtnaslpspgsENIVYL 534
                 56669***998.5588888743456**************************************66****************999888888774444*** PP

                 -SGTTSEESSSSCS......BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHH..HHHHHHHTHHHHHHHC CS
     Pkinase 140 tDFGlakelesssk......ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgke..kvekeldqlekilkil 220
                 +DFGl+k + +++        ++ +gt +Y +    k+ e s+  D+ slG +l+ +l g+ p++g +g++  ++++++ q +k +ki+
  EFC37445.1 535 IDFGLSKMYMTDKGhitlrkDKHLTGTARYASLNNHKGYEQSRRDDLESLGYVLLYFLKGTLPWQGLTGNTkeDHYNNIYQKKKNIKIV 623
                 ********999988999999999********9888888888999*********************876655004455555555555555 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.6   0.0   7.2e-15   4.3e-11       3     223 ..     340     615 ..     338     628 .. 0.77

  Alignments for each domain:
  == domain 1  score: 42.6 bits;  conditional E-value: 7.2e-15
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEE...STTSSHHHHHHHHHHHHHHHTS..-BTTB--EEEEEESSSS.................... CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtl...keeateeekeelleeakimkkl..khpnivkllgvctkeep.................... 75 
                  l +klG+GafG+V+ ++   e++++ + V + tl   ++++ ++ k++l+ eak+++ l   +pn        t++++                    
   EFC37445.1 340 LMSKLGNGAFGEVFLCQNI-EQREEYYAVKLETLptpQNGQANSGKQQLIYEAKVISYLmnAQPNSTTSSNSTTNSSNnqimsichgiprvfwfgteg 436
                  6789************999.66777777777777544456666679**********999755666666666666433323444444444444444444 PP

                  EEEEEE--TTEBHHHHHHHT..................CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE................. CS
  Pkinase_Tyr  76 llivteyvkgGdLlkfLrkk..................ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse................. 138
                  +                                      ++k++lk++l +a q+ + +ey +++++vHrd+   N L+ +                 
   EFC37445.1 437 V------------------YnimvlellgqsleslfkkCSRKFSLKTVLMLADQMIQRIEYTHKRNFVHRDIKPDNFLMGRkvpgnsptgllnllnap 516
                  1..................04444444444444444446*****************************************99**************** PP

                  ............TTEEEE-STTTHEETTTSSEE...EETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTT CS
  Pkinase_Tyr 139 ............nkvvkisDfGLardiekddey...vkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypglkneevleklkeg 221
                              +++v + DfGL++  ++d+     +k+++ +   ++ ++   k  + + + D  s G +l   ++ g  p++gl+ ++  +++++ 
   EFC37445.1 517 yqtnaslpspgsENIVYLIDFGLSKMYMTDKGHitlRKDKHLTGTARYASLNNHKGYEQSRRDDLESLGYVLLYFLK-GTLPWQGLTGNTKEDHYNNI 613
                  ************9*************98887665667888888999***********************99987777.99999998554444433333 PP

                  EE CS
  Pkinase_Tyr 222 kr 223
                  ++
   EFC37445.1 614 YQ 615
                  33 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   0.0   2.1e-11   1.2e-07     284     407 ..     435     591 ..     248     592 .. 0.74

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 2.1e-11
  Pkinase_fungal 284 nrvhrrlvispvGkpiekae.......spkellealrDaIkghrsLflkagiLHrDiSenNilit....................dskke..... 346
                     + v++++v++  G+++e          s k +l    + I+  +  + k +++HrDi  +N l+                         +     
      EFC37445.1 435 EGVYNIMVLELLGQSLESLFkkcsrkfSLKTVLMLADQMIQRIEYTH-KRNFVHRDIKPDNFLMGrkvpgnsptgllnllnapyqT---Naslps 525
                     55566666666666555322001011123333444444566666666.99***************899998888888888876641...134567 PP

  Pkinase_fungal 347 ..gerkglLiDLDlakelsddsses...garertGTleFmaievlkgeeHsyrhDLESffyvllwi 407
                       +e+   LiD+ l k + +d+ +    ++++ tGT+ + +++  kg e s r+DLES+ yvll+ 
      EFC37445.1 526 pgSENIVYLIDFGLSKMYMTDKGHItlrKDKHLTGTARYASLNNHKGYEQSRRDDLESLGYVLLYF 591
                     77888899**********9988887555669*********************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (685 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       816  (0.0455129); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.54
# Mc/sec: 3814.63
//
Query:       EFC37446.1  [L=497]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.012   15.3   3.5       0.12   12.0   0.0    2.8  3  Oxidored_q2  NADH-ubiquinone/plastoquinone oxidoreductase cha
       0.12   12.2   0.1       0.12   12.2   0.1    3.0  3  LapA_dom     Lipopolysaccharide assembly protein A domain
       0.14   12.6   4.1        3.6    8.1   0.0    2.9  3  DUF4231      Protein of unknown function (DUF4231)
          3    6.7  12.4      0.035   13.1   3.1    2.3  3  Pex24p       Integral peroxisomal membrane peroxin
        5.8    5.6   7.4         12    4.5   0.0    2.2  2  DUF2207      Predicted membrane protein (DUF2207)


Domain annotation for each model (and alignments):
>> Oxidored_q2  NADH-ubiquinone/plastoquinone oxidoreductase chain 4L
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   3.4e-05      0.12      68     104 ..      56      92 ..      31      94 .. 0.91
   2 ?    3.5   0.0     0.015        54      55      85 ..     218     248 ..     178     264 .. 0.69
   3 ?   -3.3   1.2         2   7.1e+03       7       7 ..     376     376 ..     330     413 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3.4e-05
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHSSS-BCCG-- CS
  Oxidored_q2  68 alvLtaivigaaetavgLallvrlyreygtddvqelr 104
                   l Lt+i +++a ++++++l + + ++yg d+v+ +r
   EFC37446.1  56 HLFLTLIILSVASLVFVVTLRWDVMNSYGVDEVKGMR 92 
                  589******************************9885 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.015
                  .......TTSCGGHHHHHHHHHHHHHHHHHH CS
  Oxidored_q2  55 tnpatefadplpqalvLtaivigaaetavgL 85 
                   ++++++a+++  +++L  ++ig+ ++++++
   EFC37446.1 218 AVFTSNMASIITSIIILPCLAIGFVIAVFVM 248
                  4556667777777777777777777777665 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 2
                  H CS
  Oxidored_q2   7 a 7  
                  +
   EFC37446.1 376 I 376
                  1 PP

>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.6   0.9         5   1.8e+04      26      29 ..      64      67 ..      55      77 .. 0.40
   2 ?   12.2   0.1   3.3e-05      0.12      20      55 ..     230     267 ..     219     271 .. 0.69
   3 ?   -6.3   7.5         5   1.8e+04      32      40 ..     369     377 ..     350     415 .. 0.62

  Alignments for each domain:
  == domain 1  score: -4.6 bits;  conditional E-value: 5
    LapA_dom 26 afgi 29
                  ++
  EFC37446.1 64 LSVA 67
                2222 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 3.3e-05
    LapA_dom  20 sllllvafgiGallgwllslwsyl...rlrrelrrlkkk 55 
                 s+++l +++iG++++++++  +++   +   el r++++
  EFC37446.1 230 SIIILPCLAIGFVIAVFVMK-KRFalsKEEAELLRQNQE 267
                 89***************998.344111444444444444 PP

  == domain 3  score: -6.3 bits;  conditional E-value: 5
    LapA_dom  32 llgwllslw 40 
                 ++g++ +++
  EFC37446.1 369 VIGLVGGIV 377
                 555544443 PP

>> DUF4231  Protein of unknown function (DUF4231)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0    0.0094        34       6      42 ..      44      78 ..      42      92 .. 0.80
   2 ?    8.1   0.0     0.001       3.6      42      85 ..     221     264 ..     203     267 .. 0.90
   3 ?   -2.8   0.8       2.4   8.7e+03      47      62 ..     360     375 ..     339     405 .. 0.54

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0094
     DUF4231  6 yekkasrakrrfrllrlitivlgallpilvssklgag 42
                y k+ +++ r+f+ l l++i+l++ + ++v+ +l+++
  EFC37446.1 44 YIKRLEKYDRSFH-LFLTLIILSVASLVFVV-TLRWD 78
                78999********.88888888888888887.34444 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.001
     DUF4231  42 gvsvlkiltallsalvailaaleeffrykerWrryRstaEsLkt 85 
                  ++++ i+t+++ +    +  ++++f++k+r+   ++ aE L++
  EFC37446.1 221 TSNMASIITSIIILPCLAIGFVIAVFVMKKRFALSKEEAELLRQ 264
                 5799************************************9986 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 2.4
     DUF4231  47 kiltallsalvailaa 62 
                 +++t++ ++++ ++ +
  EFC37446.1 360 PFITFVPGLVIGLVGG 375
                 3333333333333322 PP

>> Pex24p  Integral peroxisomal membrane peroxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.2      0.51   1.8e+03     151     174 ..      54      77 ..      44      82 .. 0.64
   2 ?   -1.0   0.1      0.19   6.7e+02      51      88 ..     220     257 ..     210     285 .. 0.68
   3 ?   13.1   3.1   9.7e-06     0.035      22      79 ..     332     401 ..     322     462 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.51
      Pex24p 151 stllfltllltpililllsrlipw 174
                 s  lfltl+++++  l++++ + w
  EFC37446.1  54 SFHLFLTLIILSVASLVFVVTLRW 77 
                 555666666666666666666665 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.19
      Pex24p  51 ytficlvpylelvvlplllllfvvmvpaylyrhplrks 88 
                 +t  +   +  +++lp+l + fv+ v+ + +r+ l k+
  EFC37446.1 220 FTSNMASIITSIIILPCLAIGFVIAVFVMKKRFALSKE 257
                 44445555556667888888888888777776644444 PP

  == domain 3  score: 13.1 bits;  conditional E-value: 9.7e-06
      Pex24p  22 ifplllildkvlkiltWtnpdktlsfllvytficlvpyl..............elvvlplllllfvvmvpay 79 
                 +++ll   ++++  +t t+ +k+l fl+v+ fi++vp l               + ++p+++l+f+++ +++
  EFC37446.1 332 SYELL--SYNFVATITGTSYSKWLIFLFVIPFITFVPGLviglvggivfqtisLITLCPIGMLIFMLVAFSF 401
                 67777..9*******************************************994444666666666444333 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0    0.0033        12     408     446 ..      75     263 ..      42     268 .. 0.65
   2 ?   -1.1   7.3      0.17   6.2e+02     378     435 ..     348     404 ..     288     415 .. 0.64

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0033
     DUF2207 408 l.................................................................................................. 408
                 l                                                                                                  
  EFC37446.1  75 Lrwdvmnsygvdevkgmrncmmnncsvmirpnivryedgysvpllnvtihrvywhqiskyshetwnfyygnvscndfcyseseemtlkcfrlsfpnngt 173
                 244566777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777 PP

     DUF2207 409 ....................................................lvfllilllillliaiivlllfsrllgrr...teeGaella 446
                                                                     +++ +i++l +l i++++++    ++++r   ++e aell+
  EFC37446.1 174 sgtlyyltekspflnnltlgrdrvfmidnqeyqfklvspmyydnavftsnmaSIITSIIILPCLAIGFVIAV---FVMKKRfalSKEEAELLR 263
                 777777788888888888888888888888888888888888888888633344444444444444444444...456666555777666665 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.17
     DUF2207 378 kklkklsalglgliilglilillallllvlllvfllilllillliaiivlllfsrllg 435
                 ++ k+l++l ++ +i ++ +++++l++ ++ +  +++++l  + ++i++l+ fs  l+
  EFC37446.1 348 SYSKWLIFLFVIPFITFVPGLVIGLVGGIV-FQTISLITLCPIGMLIFMLVAFSFKLP 404
                 334444444444444444444444443333.555555555555555666665555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (497 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       995  (0.0554967); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.47
# Mc/sec: 3158.82
//
Query:       EFC37447.1  [L=233]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.001   18.4   0.4        1.1    8.4   0.1    2.6  3  DUF1682   Protein of unknown function (DUF1682)
  ------ inclusion threshold ------
          3    7.8   7.9        1.7    8.6   2.2    2.6  2  ODV-E18   Occlusion-derived virus envelope protein ODV-E18


Domain annotation for each model (and alignments):
>> DUF1682  Protein of unknown function (DUF1682)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.1   0.00012       1.1       8      47 ..      15      54 ..       9      84 .. 0.84
   2 ?   -0.9   0.0     0.082   7.3e+02     216     230 ..      91     105 ..      79     115 .. 0.77
   3 !    7.2   0.0   0.00028       2.5     155     189 ..     132     166 ..     118     179 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00012
     DUF1682  8 llvllllyvlnyfiGkrkNkkiAkkwaaahkpllesnFal 47
                +lv+l++++++++ G+ +N++i++k++++++ l++s+ ++
  EFC37447.1 15 VLVVLVAVLFIAIQGTLANNNIVTKLLSQVDRLIHSDSSR 54
                7899**************************9999887555 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.082
     DUF1682 216 krlilslrlpssssd 230
                  +lils++lpssss+
  EFC37447.1  91 STLILSFKLPSSSSS 105
                 589*******99753 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.00028
     DUF1682 155 ktkdnsklpeelvvmsEsaevtealltpellkaln 189
                 +t dns lp  ++v+ Es + ++ +lt +++++l 
  EFC37447.1 132 QTIDNSTLPIYITVYGESTNTNDYVLTASVTSILP 166
                 56999****99******************999885 PP

>> ODV-E18  Occlusion-derived virus envelope protein ODV-E18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.3     0.032   2.9e+02      31      45 ..      14      28 ..       3      39 .. 0.54
   2 ?    8.6   2.2   0.00019       1.7       6      43 ..     147     185 ..     143     189 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.032
     ODV-E18 31 lvvlviiillvllvq 45
                 v++v++++l + +q
  EFC37447.1 14 KVLVVLVAVLFIAIQ 28
                233334444444444 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00019
     ODV-E18   6 Gattst.dagstrrlarlePsllltilvvlviiillvll 43 
                 G +t+t d   t  ++ + P+ ++ ++v  vii ll+l+
  EFC37447.1 147 GESTNTnDYVLTASVTSILPNWIIGVIVASVIIGLLILV 185
                 5444442777899***********************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (233 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1174  (0.0654805); expected 358.6 (0.02)
Passed bias filter:                      554  (0.0308997); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1458.64
//
Query:       EFC37448.1  [L=643]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.5e-32  110.7   1.2    3.4e-25   88.9   0.0    2.6  2  XRN_N     XRN 5'-3' exonuclease N-terminus
     0.0062   17.2   0.6      0.052   14.3   0.1    2.6  2  dsrm      Double-stranded RNA binding motif


Domain annotation for each model (and alignments):
>> XRN_N  XRN 5'-3' exonuclease N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.6   5.3e-08   0.00047       1      66 [.       1      74 [.       1      82 [. 0.66
   2 !   88.9   0.0   3.8e-29   3.4e-25      56     240 ..      97     301 ..      77     303 .. 0.78

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 5.3e-08
                XXX-HHHHHHHHHSGGGEEE---.......---SSSS.-EEEEEEETHHHHHHHHS-SSS-......--SSHHH CS
       XRN_N  1 mGvpklfrwlserypkivkevie.......eeeeeek.efdnLYlDmNgiihkcshkedkeekelskkpkteee 66
                mG++++++ ls  + + +  +++       +++ +++  +dn+Y+D+N +++k++h ++k  ++++ +++  ++
  EFC37448.1  1 MGINSFYKTLSILFGESFIITKDelnntrrNNSIKPEdVYDNIYFDFNTLLYKSTHGSRKIMNRMKYHQNVMNQ 74
                9**********9996544433333444443222444459*****************966555555544444444 PP

  == domain 2  score: 88.9 bits;  conditional E-value: 3.8e-29
                 ....--SSHHHHHHH.HHHHHHHHHHHH-EEEEEEEE------HHHHHHHHHHHHHHHHHHHHH..................HHH.HHHHHHHHHHHT- CS
       XRN_N  56 elskkpkteeeifkk.ifkyidrlvkivrprkllylavDGvaPraKmnqqRsRRfrsakeakee..................kee.keelkeelekeek 134
                 e+++ p+ ++++f++ +++ + r ++ +  r+ l+++vDG+aPr+K+  q+ RR+ +++ +++                   + e ++   + ++k+  
  EFC37448.1  97 EDEEIPQDTRMVFHSvVLEGVMRYLNHFDARESLFFSVDGPAPRSKLITQKVRRYLNSAMTNTGntfvsfinlsdmdeeivlT-EvQKIYLKLIQKNVI 194
                 45566677777776615688***********************************9888777775677766665554333221.212233333444444 PP

                 BB--------GGGSSTTSHHHHHHHHHHHHHHHHHHHH-GGG.GG-EEEEE-TTS-S-HHHHHHHHHHHHHTSTTS-TT-EEEEE---THHHHHHHHH. CS
       XRN_N 135 eeeeeeekfdsnvitpGtefmeklsealkafikkklkedpaw.knlkvilsdaevpGEGEhKimefirkqrskpeydpntrhviyglDaDLillsLat. 231
                 +e++e++++ s  + pGt++m+++s  + +  +  l+ +p++ +nl    s a + GEGE Ki+e+i +++++++ ++++r +i++ D+D +l++L + 
  EFC37448.1 195 NERNEKKAISSVWFVPGTNLMQEVSLVIWQLGALVLT-NPTFnNNLAFYHSPAGREGEGEFKILEHIYSSEKNNHKKEEKRDLIVSGDSDFVLYALNLp 292
                 55599999*****************999988887776.8999456***************************************************862 PP

                 T-SSEEEEE CS
       XRN_N 232 hepniliLr 240
                 ++++i++++
  EFC37448.1 293 RNRHITLVK 301
                 556666665 PP

>> dsrm  Double-stranded RNA binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.18   1.6e+03      47      56 ..     416     425 ..     384     427 .. 0.83
   2 !   14.3   0.1   5.8e-06     0.052      25      59 ..     469     500 ..     454     507 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.18
                 EEESSHHHHH CS
        dsrm  47 GvgsnKKeAe 56 
                  ++++KK+Ae
  EFC37448.1 416 ETSNSKKKAE 425
                 46679***99 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 5.8e-06
                 SSTSSSEEEEEEEEETTEEEEEEEESSHHHHHHHH CS
        dsrm  25 gpphslpkFvvtvkvngklygsGvgsnKKeAeqsA 59 
                  p   +p F+v vk+++  ++++ g++KK+A ++A
  EFC37448.1 469 EP---KPHFQVVVKIGESYITTARGKSKKDAFNNA 500
                 44...368*******999999**********9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (643 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1127  (0.0628591); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.55
# Mc/sec: 3548.66
//
Query:       EFC37449.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.4e-60  202.5   0.0    9.6e-60  202.0   0.0    1.2  1  ThiF          ThiF family
    6.2e-17   61.5   0.2    1.2e-16   60.6   0.2    1.5  1  E2_bind       E2 binding domain
      0.003   17.6   0.5     0.0091   16.1   0.0    2.1  2  Shikimate_DH  Shikimate / quinate 5-dehydrogenase
  ------ inclusion threshold ------
        0.1   12.2   0.1       0.19   11.3   0.1    1.4  1  CDtoxinA      Cytolethal distending toxin A/C domain


Domain annotation for each model (and alignments):
>> ThiF  ThiF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  202.0   0.0   2.1e-63   9.6e-60      16     240 ..      46     351 ..      26     356 .. 0.89

  Alignments for each domain:
  == domain 1  score: 202.0 bits;  conditional E-value: 2.1e-63
                 HHT.SEEEEE--SHHHHHHHHHHHHHTTTEEEEEESSB--GGGGGTBTTS-GGGTTSBHHHHHHHHHHHT-TTSEEEEEES-CCGCCS-HHHHTT-SEE CS
                 xxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF  16 Lrd.skvllvGaGglGsellknLalsGvgkltlvDnDkielsNlnRqflfreediGkpKaevaaealqeinpdveveavteritdetvleellesvDlV 113
                 L+d +kvl++GaGglG+ l+knLa+sG+++++++D+D+i+ sNlnRqflfr+ d+Gk Kaevaa++++e+ p+v+v+a+   i++++   ++++s+ ++
  EFC37449.1  46 LQDsCKVLIIGAGGLGCDLVKNLAMSGFRNIDIIDMDTISTSNLNRQFLFRDGDVGKMKAEVAARFVNERVPGVKVTAHICAIQEKS--VDFYRSFGII 142
                 55569******************************************************************************9986..5********* PP

                 EEESSSHHHHHHHHHHHH.HHT...............-EEEEEEEETTEEEEEEEEECCS-ECTSS-TGGS.EECCCCEEHHH................ CS
                 xxxxxxxxxxxxxxxxxx.xxx...............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................ RF
        ThiF 114 vdalDniearrlvnracv.kkg...............iplieagtlgfegqvvviipgktgcyeCldpsstedptekkvplct................ 180
                 + +lD+i+arr++n+                      i+l+++gt+gf+gq +vi+pg t+cyeC+   +   ++e ++p+ct                
  EFC37449.1 143 IAGLDSIPARRWINSTLLsL-IqyvddektevdmssmISLVDGGTEGFKGQSRVILPGVTSCYECTL--DLFPTDETNYPMCTlkttprlpehciqycy 238
                 ****************8852.357899***************************************6..4556667789******************** PP

                 ....................................................HHHCT.E-B-HHHHHHHHHHHHHHHHHHHTTBCGGGCCEEEECCTTT CS
                 ....................................................xxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF 181 ....................................................siagn.ipaiatttavvaglaalellkllsgkeklenslltqvdlle 226
                                                                     ++++  ipaia+t+a++a+ + +e+ kl   +++  + ++  +++ e
  EFC37449.1 239 ieewrnckgkegipddeqvdgdnprhvqwiyeksleraknfgiagvtfrltqGVIKGiIPAIASTNAIIASSCTNEAFKLATFCTPFLDDYM-MFNGSE 336
                 *****************************************99999999888555557***********************77777777777.466666 PP

                 TEEE.EECCEEEEEE CS
                 xxxx.xxxxxxxxxx RF
        ThiF 227 srfe.nvelerakks 240
                  +++ +++ er++++
  EFC37449.1 337 GIYTfTYKNERKPDC 351
                 655515555555555 PP

>> E2_bind  E2 binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.6   0.2   2.7e-20   1.2e-16       2      72 ..     365     437 ..     364     447 .. 0.92

  Alignments for each domain:
  == domain 1  score: 60.6 bits;  conditional E-value: 2.7e-20
     E2_bind   2 vsksttLqelidsLaerpelqlkkPsl.s.tegktLymqappsLeeatrpNLekkLkeLvedgeeitvtDkkl 72 
                 +s+++tL e+ d L +++ +q+ ++sl + t+++tLy+ +p  L+++t+pNL+kk+keL+++g+e++ tD ++
  EFC37449.1 365 CSSDITLDEFRDILRTDKSIQFNNASLrNlTSDQTLYLTKPATLRQMTEPNLKKKVKELFHTGTELYATDTEV 437
                 6899***********************62579**************************************876 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0     2e-06    0.0091      11      53 ..      48      90 ..      40     109 .. 0.83
   2 ?   -3.9   0.1         3   1.3e+04      79      98 ..     296     315 ..     296     319 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 2e-06
                  TT-EEEEES-SHHHHHHHHHHHCCT-CEEEEEESSHHHHHHHH CS
  Shikimate_DH 11 kekkvlliGaGemaelvakhLlakgvkkvvvaNRtlerakela 53
                  +++kvl+iGaG ++  ++k+L+ +g++++ ++  +    ++l 
    EFC37449.1 48 DSCKVLIIGAGGLGCDLVKNLAMSGFRNIDIIDMDTISTSNLN 90
                  679**************************99876665555555 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 3
                   EEE-SSSSS-SB-HHHHHCC CS
  Shikimate_DH  79 visataseepilekeeveea 98 
                   +i a+as+++i+ ++  +ea
    EFC37449.1 296 IIPAIASTNAIIASSCTNEA 315
                   57788888888887766655 PP

>> CDtoxinA  Cytolethal distending toxin A/C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   4.2e-05      0.19      53     105 ..     340     392 ..     327     419 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 4.2e-05
                 -EEEEETTT--EEEEETTEEEEE-.--TT-GGG-EEEEEBTTS-EEEEETTT- CS
    CDtoxinA  53 lvqfknvdegtClaayenGvialkkCdeddketvFsliptttgavqikslssg 105
                 ++ +kn  +++Cl+    Gv + ++C++d    +F  i  t   +q+ ++s  
  EFC37449.1 340 TFTYKNERKPDCLQCGPAGVSKTITCSSDITLDEFRDILRTDKSIQFNNASLR 392
                 56789999*********************9999***99999999999987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       478  (0.0266607); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 3018.29
//
Query:       EFC37450.1  [L=816]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.3e-06   26.7   3.9    4.6e-06   26.6   0.6    2.8  3  Polbeta         Polymerase beta, Nucleotidyltransferase
    0.00058   20.1   0.2     0.0021   18.3   0.2    2.0  1  NTP_transf_2    Nucleotidyltransferase domain
  ------ inclusion threshold ------
       0.19   11.8   2.4        5.9    7.1   0.1    3.6  3  YqzH            YqzH-like protein
       0.29   11.3   2.8        7.9    6.7   1.1    2.7  2  DUF4710         Domain of unknown function (DUF4710)
       0.53   10.0   6.3       0.17   11.6   0.7    3.1  3  Integrin_b_cyt  Integrin beta cytoplasmic domain


Domain annotation for each model (and alignments):
>> Polbeta  Polymerase beta, Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.6   0.6   1.3e-09   4.6e-06       6      58 ..      64     118 ..      62     142 .. 0.83
   2 ?   -2.9   0.1       2.1   7.6e+03      42      69 ..     279     309 ..     273     318 .. 0.69
   3 ?   -2.1   0.0       1.1   4.1e+03      74      88 ..     428     442 ..     398     443 .. 0.84

  Alignments for each domain:
  == domain 1  score: 26.6 bits;  conditional E-value: 1.3e-09
                 THHHHHHHHSTTEEEEEE-S------EEEEEEEESS-..--HHHHHHHHHHHHHH CS
     Polbeta   6 ilekekeielaylFGSrakgkareeSDiDlavllkek..ldleeelelaaeledi 58 
                 +l ++++i+ +y+FGSr++++  ++SD+Dl +++++   + +++e +++++l+ +
  EFC37450.1  64 VLYRDDSIRGIYVFGSRVSKTNVNDSDFDLIMIVDDFysHCIDYETRYSNNLQYL 118
                 6677789*****************************9876666677777777776 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.1
                 -..--HHHHHHHHHHHHHH..SSSEEEEEET CS
     Polbeta  42 k..ldleeelelaaeledi.klgkkvDlvdl 69 
                 +   +++e+ +++++l +  k++ k Dl ++
  EFC37450.1 279 DsfSSWNEYKQISDALYKTwKEQLKDDLKNI 309
                 3347888888888888888877777777764 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.1
                 HHHHHHHHHS-EEEE CS
     Polbeta  74 plllyeilkegklly 88 
                 ++l y+i  +gk++y
  EFC37450.1 428 TVLSYNIDDNGKIVY 442
                 78999*******999 PP

>> NTP_transf_2  Nucleotidyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.2   5.7e-07    0.0021      14      48 ..      71     116 ..      60     164 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 5.7e-07
                   TSEEEEEHHHHCTTSCTTSSEEEEEEESTTCHHH............H CS
  NTP_transf_2  14 vakvvlfGSyarGtalkgSDiDllvvlpeevsre............k 48 
                   +  +++fGS++  t+  +SD Dl+ +++++ s              +
    EFC37450.1  71 IRGIYVFGSRVSKTNVNDSDFDLIMIVDDFYS-HcidyetrysnnlQ 116
                   778**************************944.14544444444440 PP

>> YqzH  YqzH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.37   1.3e+03      37      57 ..      80     100 ..      78     105 .. 0.85
   2 ?    7.1   0.1    0.0016       5.9      26      59 ..     282     315 ..     276     317 .. 0.90
   3 ?    1.7   0.1     0.076   2.7e+02      25      48 ..     518     541 ..     504     544 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.37
        YqzH  37 riqekkkeqedeDlyeiveDi 57 
                 r+ +   +++d Dl  iv+D 
  EFC37450.1  80 RVSKTNVNDSDFDLIMIVDDF 100
                 677788899*********995 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0016
        YqzH  26 lseeeqkeLveriqekkkeqedeDlyeiveDivY 59 
                  s +e k+  +++ +  keq + Dl +i++D+ +
  EFC37450.1 282 SSWNEYKQISDALYKTWKEQLKDDLKNIIKDALF 315
                 5679***************************976 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.076
        YqzH  25 plseeeqkeLveriqekkkeqede 48 
                    e+e+++L eri  k+ ++ed+
  EFC37450.1 518 SQTEQEFENLFERIGMKYPSHEDQ 541
                 4568999**********9999985 PP

>> DUF4710  Domain of unknown function (DUF4710)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   1.1    0.0022       7.9      32      55 ..     227     250 ..     218     255 .. 0.85
   2 ?    3.1   0.0     0.029     1e+02      34      73 ..     296     339 ..     275     341 .. 0.71

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0022
     DUF4710  32 kkkkkkqklKKyrKnvgKalrlsw 55 
                 ++  +k+ lKK++Kn+   +r+s+
  EFC37450.1 227 DESERKSTLKKVKKNLAHGIRYSK 250
                 4567899**************996 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.029
     DUF4710  34 kkkkqklKKyrKnvgKalrlswr....cLvlGlqnlaaaYstPl 73 
                 k  k++lK   Kn+ K + ++++       lG+qn+ + Ys+ +
  EFC37450.1 296 KTWKEQLKDDLKNIIKDALFKCKnsesNSSLGIQNFLNTYSSGF 339
                 5567777777788888766666622213578*********9865 PP

>> Integrin_b_cyt  Integrin beta cytoplasmic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.51   1.8e+03      27      33 ..     341     347 ..     339     354 .. 0.83
   2 ?   -3.6   0.5       2.6   9.4e+03      10      25 ..     568     583 ..     565     584 .. 0.82
   3 ?   11.6   0.7   4.6e-05      0.17      14      42 ..     682     710 ..     681     711 .. 0.95

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.51
  Integrin_b_cyt  27 geNPlYk 33 
                     ++NPl+ 
      EFC37450.1 341 KDNPLFS 347
                     79***97 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 2.6
  Integrin_b_cyt  10 rEyakFekerkkakWe 25 
                     +Ey+++     k +W+
      EFC37450.1 568 MEYENWIDFSTKYNWN 583
                     8999999888888886 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 4.6e-05
  Integrin_b_cyt  14 kFekerkkakWeegeNPlYkkatttfkNP 42 
                     kF ++++  +  ++ NPl+ k+ ++fkN+
      EFC37450.1 682 KFSNQVNEDHLVNNLNPLFTKPFSQFKNI 710
                     999*************************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (816 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       988  (0.0551063); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 4952.45
//
Query:       EFC37451.1  [L=1074]
Description: hypothetical protein NAEGRDRAFT_81916 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.5e-12   46.4   3.5    3.5e-12   46.4   3.5    3.6  3  Clathrin        Region in Clathrin and VPS
    8.1e-09   35.6   0.3    8.1e-09   35.6   0.3    2.2  2  VPS11_C         Vacuolar protein sorting protein 11 C termina
    4.5e-06   26.6   7.2    1.5e-05   25.0   7.2    2.0  1  zf-C3H2C3       Zinc-finger
  ------ inclusion threshold ------
      0.019   14.8   6.1      0.046   13.6   6.1    1.7  1  zf-C3HC4_2      Zinc finger, C3HC4 type (RING finger)
      0.076   12.9   0.0       0.41   10.6   0.0    2.3  1  BBS2_N          Ciliary BBSome complex subunit 2, N-terminal
        0.1   13.0   6.4       0.26   11.7   6.4    1.8  1  zf-RING_2       Ring finger domain
       0.25   11.4   4.1       0.66   10.1   4.1    1.7  1  zf-RING_UBOX    RING-type zinc-finger
       0.94    9.8   4.3        3.6    8.0   4.3    2.0  1  zf-rbx1         RING-H2 zinc finger domain
        1.8    8.6   6.4        5.9    6.9   6.4    2.0  1  zf-RING_5       zinc-RING finger domain
        4.9    6.2   7.7         13    4.8   7.7    1.6  1  Astro_capsid_p  Turkey astrovirus capsid protein


Domain annotation for each model (and alignments):
>> Clathrin  Region in Clathrin and VPS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.4   3.5     2e-15   3.5e-12       8     113 ..     420     526 ..     417     563 .. 0.84
   2 ?    2.2   4.7     0.087   1.6e+02      39     135 ..     711     843 ..     693     850 .. 0.74
   3 ?   -3.3   0.1       4.2   7.5e+03      81     113 ..     880     913 ..     874     921 .. 0.72

  Alignments for each domain:
  == domain 1  score: 46.4 bits;  conditional E-value: 2e-15
                 S-CCCCHHHHHCTT-HHHHCHHHCCHHHCHTS--HHHHHHHHHHHHHT..T-HHHHHHTTSS---..S-TTHHHHHHHT-SSHHHHHHHHHTTXTHSSH CS
    Clathrin   8 idlsrvvklfeeaglleelleyLekvlkedskenpalqtallelyaky..ddpqeleeflkknnn..ydlekvaklcekadlyeeavilykkinefkka 102
                 ++ s v++ f +a++++ l+eyLe +  e++ ++++  t+ll +y k   ++ ++l++f+++ ++  yd+e+++++c+ka++ e a+il  k+++++  
  EFC37451.1 420 LEPSYVIRKFLDANRIRNLTEYLETLH-EKRLATSDHTTLLLNCYTKLkdERKEKLDKFISMQDKlmYDVETAIRVCRKAGYKEHALILAMKHKQHDWY 517
                 67888**********************.677799************99885569*******************************************99 PP

                 SSX.SSSSHCSC CS
    Clathrin 103 isl.lkklkdfd 113
                 i++ l+   dfd
  EFC37451.1 518 IKIhLE---DFD 526
                 996333...333 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.087
                 S--HHHHHHHHHHHHHT...................................T-HHHHHHTTSS---.S-TTHHHHHHHT-SSHHHHHHHHHTTXTHSS CS
    Clathrin  39 kenpalqtallelyaky...................................ddpqeleeflkknnn.ydlekvaklcekadlyeeavilykkinefkk 101
                   ++ +++ l+ely+ky                                   +d  +l+  l+  ++ yd+e v+ l + ++  e  + +y+ ++ +  
  EFC37451.1 711 SHSKVVYNTLIELYLKYldtdskkrpeleqtqgisdryeiqppstdianlsfKD--RLLYTLDHPQSnYDKEHVLVLVQSQNFKEGVLKIYDTLGLHYY 807
                 356889999999999998888888888888888888888888888777776544..7777777555568888888888888888777778888888888 PP

                 HSSXSSSSHCSCHHHHTTTTTXX..SHHHHHHHHHH CS
    Clathrin 102 aisllkklkdfddaieyaakvsn..pelweklleal 135
                  i+ + +  d+++ i  + +  +  p+lw ++l ++
  EFC37451.1 808 IIQYYMEQRDYKNVIASVNQYGDkdPNLWVQVLTYF 843
                 888867778888888888887776688888888876 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 4.2
                 HT-SSHHHHHHHHHTTXTHSSHSSX.SSSSHCSC CS
    Clathrin  81 ekadlyeeavilykkinefkkaisl.lkklkdfd 113
                 ek++ly    +l +ki++ +++i   ++k k+f+
  EFC37451.1 880 EKTKLYSVKDYLISKIQKEQEMIREdVEKIKEFQ 913
                 6778888888888888888887775566666665 PP

>> VPS11_C  Vacuolar protein sorting protein 11 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.7       3.7   6.6e+03       4      20 ..     892     908 ..     892     913 .. 0.81
   2 !   35.6   0.3   4.5e-12   8.1e-09       1      43 [.     978    1021 ..     978    1021 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 3.7
     VPS11_C   4 irelrraQeesadrhdl 20 
                 i ++ ++Qe++ ++ + 
  EFC37451.1 892 ISKIQKEQEMIREDVEK 908
                 6789999**99998876 PP

  == domain 2  score: 35.6 bits;  conditional E-value: 4.5e-12
     VPS11_C    1 netirelrraQeesadrhdlFkaaLees.eDrFkvvadyFGRGv 43  
                  ++ i + +r+ ees+++h+ F+++L+ +  D+ ++v +yFGRG+
  EFC37451.1  978 HRDILQRKRKFEESSEQHESFFKQLNTKkLDGYSLVCEYFGRGI 1021
                  6789999********************66**************6 PP

>> zf-C3H2C3  Zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   7.2   8.1e-09   1.5e-05       1      34 [.     938     974 ..     938     975 .. 0.86

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 8.1e-09
   zf-C3H2C3   1 CdnCglkLdypfvaysCkHlvHakC...adeevCPkC 34 
                 C  C  +Ld p v++ C+H++H+ C   ++e  C  C
  EFC37451.1 938 CTFCNAQLDLPAVHFMCNHSYHQRCllvGNEGECRVC 974
                 999**********************875566667666 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   6.1   2.6e-05     0.046       2      40 .]     938     974 ..     937     977 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.6e-05
  zf-C3HC4_2   2 CpiCldmlkdpsvvtpCgHvfCqkCilrsLeekneCPlC 40 
                 C+ C + l  p v + C+H+++q C+l    ++ eC +C
  EFC37451.1 938 CTFCNAQLDLPAVHFMCNHSYHQRCLLV--GNEGECRVC 974
                 **************************98..477788877 PP

>> BBS2_N  Ciliary BBSome complex subunit 2, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00023      0.41       5      93 ..     137     223 ..     134     231 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00023
      BBS2_N   5 fdgshp..claaattagkvlihnphekeqklkserlsasesevslLn..inkevtalaagklkekqekdiLligtqtnllaYdveeNsdlFyk 93 
                 f+ ++   c+a++   gk++i++   ++q  ks      +++v lL+   n+++t l   ++ ++ +  +L+ ++ t+++ Y++++Ns+  ++
  EFC37451.1 137 FEANQDfnCIALGLGNGKIIIFEGDFTKQGGKS------SHKVFLLDgaPNERITGLGFKRYGNSPNDYTLFCCSLTQVFKYSINTNSSTSQR 223
                 66554444***************8666544444......7888888633699*************9999******************987666 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   6.4   0.00014      0.26       2      43 ..     937     974 ..     936     975 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00014
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreClerwlrssstCPlC 43 
                 +C+ C  +l+    v+ + C+H++h+ Cl  ++ ++ +C +C
  EFC37451.1 937 TCTFCNAQLD-LPAVHFM-CNHSYHQRCL--LVGNEGECRVC 974
                 7****88885.4788888.*********9..66999999999 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   4.1   0.00037      0.66       1      26 [.     938     967 ..     938     987 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00037
  zf-RING_UBOX   1 CpIClelftdP...lvlpCGHtFCreCl...w 26 
                   C+ C+ +++ P       C H+++++Cl    
    EFC37451.1 938 CTFCNAQLDLPavhF--MCNHSYHQRCLlvgN 967
                   999******995331..3**********4431 PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   4.3     0.002       3.6      12      41 ..     936     963 ..     929     975 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.002
     zf-rbx1  12 eacieckapgdeecpvvlGeCgHaFHlhCi 41 
                  +c+ c+a+ d   p v   C+H++H+ C+
  EFC37451.1 936 TTCTFCNAQLDL--PAVHFMCNHSYHQRCL 963
                 567788887775..888889*********8 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   6.4    0.0033       5.9       2      43 ..     938     975 ..     934     976 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0033
   zf-RING_5   2 CnkCfeklskeekfyltsCgHifCekClkkllekeavCpiCr 43 
                 C  C  +l  + +++   C H+++++Cl      e +C +C+
  EFC37451.1 938 CTFCNAQL--DLPAVHFMCNHSYHQRCLLVGN--EGECRVCS 975
                 88888888..89999999**************..99999996 PP

>> Astro_capsid_p  Turkey astrovirus capsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   7.7    0.0071        13     257     289 ..    1044    1073 ..    1027    1073 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0071
                      XXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXX CS
  Astro_capsid_p  257 deDeddevdrfDletsyeSeaeDddvennRvtL 289 
                      deDe++++d+    ++++S+ eDdd++ +R +L
      EFC37451.1 1044 DEDEEEDEDDV---SNFTSDDEDDDIDRRRRLL 1073
                      45555555544...889**********999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1074 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1723  (0.0961013); expected 358.6 (0.02)
Passed bias filter:                      689  (0.0384294); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.91u 0.33s 00:00:01.24 Elapsed: 00:00:00.53
# Mc/sec: 6105.77
//
Query:       EFC37452.1  [L=785]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-17   64.0   0.4    2.8e-17   62.9   0.2    1.6  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
      0.017   14.9   0.5      0.017   14.9   0.5    1.9  2  dCache_1       Cache domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0      0.58   5.2e+03      43      65 ..     474     496 ..     456     509 .. 0.64
   2 !   62.9   0.2   3.2e-21   2.8e-17       6     178 ..     537     718 ..     535     724 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 0.58
  Guanylate_cyc  43 delldekkvykvktiGdaymvvs 65 
                    ++l++e + +k+ t G  ++ + 
     EFC37452.1 474 KSLASESDNTKITTAGQIFYDIG 496
                    34555556999999999888665 PP

  == domain 2  score: 62.9 bits;  conditional E-value: 3.2e-21
  Guanylate_cyc   6 ydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp....eekaahaaklaelaLdmlealeevaves. 96 
                     +++til ++I++ft+l++ ++    v+++ ++++++ + ++ +++  + + Gd   +v + +    ee++  a+k+a  aL+++++l+ +  ++ 
     EFC37452.1 537 LQNMTILVSSIKDFTQLAELTETSIFVSVMTDYFGSLTKAMEDHRGLIDMINGDRLQAVWNDSsmpvEEHEVRACKAAMEALEIIDELNIMWRNEr 632
                    589******************************************************999888766666666677777777777777754443333 PP

  Guanylate_cyc  97 ..keglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgk..agkiqvseetyellkeeqfeltergevevkGkgklet 178
                        +l++ v +++G ++ g +G +++ +++ +G++vn+ s+++s+    +++i +se+ty+  k ++f +   + + +kGk++ + 
     EFC37452.1 633 qiDIDLSIYVSVSSGNMMYGSMGsENRLNFTAIGDDVNIGSKLQSLNRyyGSNILISENTYQHVK-NEFVCYFADYILLKGKETPTR 718
                    455889999**************99*********************973368999**********.9**************876654 PP

>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1      0.33   2.9e+03      15      70 ..     164     215 ..     160     282 .. 0.52
   2 ?   14.9   0.5   1.9e-06     0.017      58     169 ..     320     430 ..     289     434 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.33
    dCache_1  15 aeqlanniedvldslenlaetlasnpslqdlleepnra...neasreslqallksilks 70 
                 a+q+ + +   + ++ n+++++     +q+ +++   +   +++++ +++ +lk + + 
  EFC37452.1 164 AQQTQSYVTFEIGKIINTSNLI-----IQQ-VKMEV-EngfPLKNITEWAIFLKYLRSV 215
                 5666666666666666666666.....222.22211.1245555555555555543332 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 1.9e-06
    dCache_1  58 eslqallksilksnpdisgvylvdadGqviassdpssppnleg....tddpadrdwykealaggggkpvisdpyvdqt.ggkpvitiavpiyddsgkfi 151
                 + l+++l+s+ +s+++is+ ++   +G+viass++++  +  +    ++ +   +++++    ++   + s++ ++    gk+  ++++p+ d+ g  +
  EFC37452.1 320 KGLNSFLNSTSRSYNFISYSFIMETNGNVIASSRYNTT-KFTVhtgdGEIFEIANYIQDKELLKN---ITSNVPISLKyRGKN--VVITPVVDPYGLSL 412
                 55899**************************8876654.43337888555555666665555453...345555333312433..56789999669999 PP

    dCache_1 152 Gvlaadldldnlqdllsn 169
                   +++++d+d + ++ls+
  EFC37452.1 413 ALVIGSVDADIFAEILSS 430
                 999****99999999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (785 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       819  (0.0456802); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.40
# Mc/sec: 5835.43
//
Query:       EFC37453.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.1e-13   51.2   8.5    1.8e-13   50.6   5.3    2.1  2  Rogdi_lz   Rogdi leucine zipper containing protein
  ------ inclusion threshold ------
      0.093   12.8   0.0        9.4    6.4   0.0    2.6  2  DCX        Doublecortin


Domain annotation for each model (and alignments):
>> Rogdi_lz  Rogdi leucine zipper containing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   1.6     0.036   3.2e+02      86     156 ..      29      98 ..      11     134 .. 0.58
   2 !   50.6   5.3     2e-17   1.8e-13      33     195 ..     152     350 ..      53     389 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.036
    Rogdi_lz  86 eqLtdlrtlltqaldlLdltlktgdelsks.aqflssqLrllleslseAkalLkgppepelafpangwttes 156
                 + L+d++++ ++ +  L++++   +el+++  + + +q  ++ +++++A  lL g+ + +l + +n+ +++s
  EFC37453.1  29 SMLKDVKNMKEEEIASLEQETM-MKELRHLlYDIVPQQWSKIINEIQQAVGLLGGEVK-HLQSMENNSNNNS 98 
                 4455555555555566652222.22222223556666777777777777777777777.5444444422222 PP

  == domain 2  score: 50.6 bits;  conditional E-value: 2e-17
    Rogdi_lz  33 pgstLvlSssrsesvKGvvtRvGtrivkgdislrlrtlpk.ltlklnptkpivleqLtdlrtlltqaldlLd...........ltlktgdelsks.... 115
                 + ++L +  +++  +KG +  +G ri+ g+i+ +l+++++ +  +++p++p+ l+q++ ++++ + al+ ++                           
  EFC37453.1 152 ERIQLHINDQNHAILKGYLLVDGYRILGGKINFKLHKMKQsCEAEIRPNDPYTLSQIQRAHHMADYALNKMKnidiekysensN----------Ivleg 240
                 367888899*******************************9*****************************98644444444440..........25666 PP

    Rogdi_lz 116 ......................aqflssqLrllleslseAkalLkgppepelafpang.....wttesaa...shfePplppnlsldlyiqeaelvldl 184
                                        +++ + L+ ++  +++ ++ L++      +  +++      ++ +++   ++f P lp++  ++++i +a+l + +
  EFC37453.1 241 ddevdlmnstylskttskierdVTTILTILERVMILVQQGREQLTTYGGLRFLTDEYRlsssiSEKANIEllqQSFHPRLPKETLIEFSITNAQLHVGV 339
                 6666667777777777888889999********************9998444444434677663334444667************************** PP

    Rogdi_lz 185 rvLepvtakpw 195
                 + L  ++   +
  EFC37453.1 340 YGLSYTSIATS 350
                 ***97776553 PP

>> DCX  Doublecortin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0    0.0081        72       8      36 ..      64      93 ..      64     114 .. 0.83
   2 ?    6.4   0.0     0.001       9.4       2      35 ..     384     417 ..     383     418 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0081
         DCX  8 rsfealLdeltekvklpfg.VrklytldGr 36
                +++ ++ +e+ ++v l  g V++l +++  
  EFC37453.1 64 QQWSKIINEIQQAVGLLGGeVKHLQSMENN 93
                579999**********8889****999865 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.001
         DCX   2 lnkrrfrsfealLdeltekvklpfgVrklytldG 35 
                 ++k ++ sf + Ld+lt++ k+ +  r+l t+ G
  EFC37453.1 384 ISKITVASFSSGLDHLTNAFKMCSRLRNLLTTHG 417
                 6788999***************989****99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1910  (0.106531); expected 358.6 (0.02)
Passed bias filter:                      671  (0.0374254); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 2478.74
//
Query:       EFC37454.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.7e-05   22.5   0.6        0.3   11.2   0.0    4.8  5  NHL       NHL repeat
  ------ inclusion threshold ------
      0.043   13.4   0.1          9    5.8   0.0    3.0  3  SGL       SMP-30/Gluconolactonase/LRE-like region


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0     0.062   5.5e+02      15      28 .]      96     109 ..      81     111 .. 0.70
   2 ?   -2.2   0.0      0.59   5.3e+03      12      20 ..     196     205 ..     195     209 .. 0.77
   3 !   11.2   0.0   3.3e-05       0.3       2      22 ..     230     250 ..     229     256 .. 0.85
   4 ?   -0.3   0.0      0.15   1.3e+03       6      22 ..     277     294 ..     276     299 .. 0.83
   5 !    3.7   0.0    0.0079        71       3      27 ..     316     341 ..     316     342 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.062
                 EEEEECCCTEEEEE CS
         NHL  15 iyVaDsenhrvqvF 28 
                 i+V+D   +r++vF
  EFC37454.1  96 ILVCDQLKNRIVVF 109
                 89999888888888 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.59
                 TTEEEEEE.C CS
         NHL  12 nGdiyVaD.s 20 
                 ++ i+V++ +
  EFC37454.1 196 QNLILVCEkT 205
                 799***9855 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 3.3e-05
                 SSEEEEEEETTTEEEEEECCC CS
         NHL   2 nyPhGvavdsnGdiyVaDsen 22 
                   P++++ +s Gd+++ D+  
  EFC37454.1 230 LGPWSISFNSLGDLIIGDCDK 250
                 68****************875 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.15
                 EEEEE.TTTEEEEEECCC CS
         NHL   6 Gvavd.snGdiyVaDsen 22 
                 G+++d sn+ iy +D+ n
  EFC37454.1 277 GLSIDySNDYIYASDFAN 294
                 788999999999999776 PP

  == domain 5  score: 3.7 bits;  conditional E-value: 0.0079
                 SEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvqv 27 
                 +P G+ +d ++G+++ +D+ ++++++
  EFC37454.1 316 NPIGIHIDnKGGRLLFSDYSSMHLVC 341
                 599***************77777776 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0    0.0037        33     139     172 ..      87     116 ..      65     135 .. 0.81
   2 ?   -1.3   0.0      0.14   1.3e+03      49      77 ..     194     224 ..     170     253 .. 0.59
   3 ?    5.8   0.0     0.001         9     175     222 ..     268     311 ..     223     318 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.0037
         SGL 139 lawspdgktlYlaDsltrkiwaydvdaeggklsn 172
                 + +s d + ++++D l+++i+++d+++     ++
  EFC37454.1  87 VKISTDYQCILVCDQLKNRIVVFDYNTL----KQ 116
                 67999********************743....33 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.14
         SGL  49 rkdgrlvvasksglall..dlasgeletlad 77 
                 ++++ ++v++k++  ++  d ++g++   ++
  EFC37454.1 194 YNQNLILVCEKTEKQIQflDSNTGSVLRSIS 224
                 4447778888887777766666665543333 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.001
         SGL 175 vfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfdpdGklieeikl 222
                  f ++k+    + Gl +D ++ ++ A   ++ +++f+p G+l+++i+ 
  EFC37454.1 268 SFGTFKD----IYGLSIDYSNDYIYASDFANAIQVFTPTGELVKKITH 311
                 3333333....44999**95555555555899************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.35s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1994.09
//
Query:       EFC37455.1  [L=266]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      5e-78  256.7  17.2    2.3e-20   72.0   0.0    5.9  6  DUF4116        Domain of unknown function (DUF4116)
    0.00014   22.0   0.0        4.4    7.4   0.0    4.4  5  Rsbr_N         Rsbr N terminal
     0.0022   18.1   0.1      0.077   13.1   0.0    2.3  2  DUF4853        Domain of unknown function (DUF4853)
  ------ inclusion threshold ------
      0.018   15.3   1.6        1.4    9.2   0.2    3.1  3  GLTP           Glycolipid transfer protein (GLTP)
      0.091   12.8   0.2       0.33   11.0   0.1    2.0  2  DUF3288        Protein of unknown function (DUF3288)
        1.6    9.1   3.6        2.9    8.4   0.1    3.1  3  RII_binding_1  RII binding domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   0.0     3e-12   9.1e-09      12      49 .]      40      77 ..      35      77 .. 0.93
   2 !   72.0   0.0   7.7e-24   2.3e-20       1      49 []      79     127 ..      79     127 .. 0.99
   3 !   38.4   0.3   2.4e-13   7.2e-10      17      49 .]     130     162 ..     130     162 .. 0.98
   4 !   57.5   0.1   2.7e-19     8e-16       1      49 []     139     187 ..     139     187 .. 0.98
   5 !   59.1   0.0   8.3e-20   2.5e-16       1      49 []     164     212 ..     164     212 .. 0.98
   6 !   35.7   1.6   1.7e-12   5.2e-09       1      33 [.     189     221 ..     189     263 .. 0.93

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 3e-12
     DUF4116 12 ngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                n  +lk+++++ +n+++i+ +Avk+ng++lsyas+ L+
  EFC37455.1 40 NVHVLKNAPHDVRNNRQIISQAVKRNGYSLSYASDRLK 77
                56789******************************996 PP

  == domain 2  score: 72.0 bits;  conditional E-value: 7.7e-24
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eiv+ av+++gsal+++s++L+nD++ivl+Avkqn +a++yas+ Lr
  EFC37455.1  79 DKEIVKLAVSQYGSALQFASDSLRNDRDIVLAAVKQNYHAFEYASPILR 127
                 9*********************************************998 PP

  == domain 3  score: 38.4 bits;  conditional E-value: 2.4e-13
     DUF4116  17 kylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ky+s+eLknD e+vlk vk+ng++l++as++Lr
  EFC37455.1 130 KYASSELKNDLELVLKVVKINGNNLEFASKKLR 162
                 7******************************98 PP

  == domain 4  score: 57.5 bits;  conditional E-value: 2.7e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D E+vl++vk+ng++l+++s++L++D+ +vl+Av + g+al++as+++r
  EFC37455.1 139 DLELVLKVVKINGNNLEFASKKLRKDRRVVLEAVSNKGSALKFASNDMR 187
                 89*******************************************9987 PP

  == domain 5  score: 59.1 bits;  conditional E-value: 8.3e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr +vleav++ gsalk++s++++n++eivlkA+ q+g+al++as++L+
  EFC37455.1 164 DRRVVLEAVSNKGSALKFASNDMRNNREIVLKAILQDGNALKFASDSLK 212
                 899*******************************************997 PP

  == domain 6  score: 35.7 bits;  conditional E-value: 1.7e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkA 33 
                 +rEivl+a+ ++g+alk++s++Lk+Dk ++  A
  EFC37455.1 189 NREIVLKAILQDGNALKFASDSLKSDKKLIEIA 221
                 8**************************888766 PP

>> Rsbr_N  Rsbr N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.028        83      36      91 ..       9      62 ..       4      76 .. 0.72
   2 ?   -0.2   0.0      0.34     1e+03      64      86 ..      60      82 ..      41      89 .. 0.72
   3 ?    4.3   0.0     0.014        40      67      94 ..      88     115 ..      68     125 .. 0.85
   4 !    7.4   0.0    0.0015       4.4      39      95 ..     120     176 ..     112     192 .. 0.80
   5 ?    1.2   0.0      0.12   3.6e+02      66      86 ..     197     217 ..     179     254 .. 0.72

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.028
                HHHHHHHHHHH-SS.-SSTTHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHH CS
      Rsbr_N 36 tskefvdlilssveegneeleekleefaerlvqlGwpLkyltkgLqefrkvvlell 91
                + + +v +i ++ +   +e+ e+++++++r+v +   Lk   + ++  r+++ +++
  EFC37455.1  9 IYHHLVPIIAHNFT--SSEIPESIDDYSSRIVSNVHVLKNAPHDVRNNRQIISQAV 62
                55566667777777..7889999********9987777766666666666665555 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.34
                HHHHHTT--HHHHHHHHHHHHHH CS
      Rsbr_N 64 erlvqlGwpLkyltkgLqefrkv 86
                + + ++G +L+y ++ L+  +++
  EFC37455.1 60 QAVKRNGYSLSYASDRLKNDKEI 82
                44457899****99998875555 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.014
                 HHTT--HHHHHHHHHHHHHHHHHHHHH. CS
      Rsbr_N  67 vqlGwpLkyltkgLqefrkvvlellsee 94 
                  q G  L++ +++L+  r++vl++++++
  EFC37455.1  88 SQYGSALQFASDSLRNDRDIVLAAVKQN 115
                 489*******************999885 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.0015
                 HHHHHHHH-SS.-SSTTHHHHHHHHHHHHHT.T--HHHHHHHHHHHHHHHHHHHHH.. CS
      Rsbr_N  39 efvdlilssveegneeleekleefaerlvql.GwpLkyltkgLqefrkvvlellseed 95 
                 e+   il + +   +el+++le  + ++v++ G  L++ +k L++ r+vvle++s++ 
  EFC37455.1 120 EYASPILRNDKYASSELKNDLE-LVLKVVKInGNNLEFASKKLRKDRRVVLEAVSNKG 176
                 6667777777777777777775.678888844*********************99975 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.12
                 HHHTT--HHHHHHHHHHHHHH CS
      Rsbr_N  66 lvqlGwpLkyltkgLqefrkv 86 
                 + q G  Lk+ +++L++ +k+
  EFC37455.1 197 ILQDGNALKFASDSLKSDKKL 217
                 557788888888888765554 PP

>> DUF4853  Domain of unknown function (DUF4853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   0.0   2.6e-05     0.077      59     110 ..      46      96 ..      28     101 .. 0.87
   2 ?    2.6   0.0     0.047   1.4e+02      58     123 ..     155     207 ..     144     219 .. 0.54

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.6e-05
                 EE---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEE CS
     DUF4853  59 ipeidfddlrevveeelkplGfkysekpderdkdesrtvvwgderyGgslsv 110
                  + +d+   r+++++++k++G+++s   d+ ++d++ + ++ ++ yG  l++
  EFC37455.1  46 NAPHDVRNNRQIISQAVKRNGYSLSYASDRLKNDKEIVKLAVSQ-YGSALQF 96 
                 456888899****************************7788888.***9998 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.047
                 EEE---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEEEE-SS.EEEEEEE CS
     DUF4853  58 yipeidfddlrevveeelkplGfkysekpderdkdesrtvvwgderyGgslsvkyseddrisvhye 123
                 ++++    + r+vv e+++ +G +++    +++++ + ++ +  + +G+ l++             
  EFC37455.1 155 EFASKKLRKDRRVVLEAVSNKGSALKFASNDMRNNREIVLKAILQ-DGNALKF------------A 207
                 555555555555555555555555555555555555555544444.4554444............3 PP

>> GLTP  Glycolipid transfer protein (GLTP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.091   2.7e+02      23      61 ..      43      81 ..      21      94 .. 0.78
   2 ?    2.7   0.0     0.046   1.4e+02      13      61 ..      82     131 ..      76     146 .. 0.80
   3 ?    9.2   0.2   0.00046       1.4      16      60 ..     171     215 ..     141     260 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.091
                GGGGHHHHTHHHHHHHHHHTT....T-SBHHHHHHHHHH CS
        GLTP 23 afsfvksDvegniekleeaykknpeeystleslveaEke 61
                +++ + +Dv++n +++ +a+k+n    s+  + ++++ke
  EFC37455.1 43 VLKNAPHDVRNNRQIISQAVKRNGYSLSYASDRLKNDKE 81
                6777889**************996666667777777765 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.046
                 HHHHH.HHT-GGGGGHHHHTHHHHHHHHHHTT....T-SBHHHHHHHHHH CS
        GLTP  13 lvklf.dllGsafsfvksDvegniekleeaykknpeeystleslveaEke 61 
                 +vkl   + Gsa++f++  ++++ +++  a+k+n +++++   +++++k 
  EFC37455.1  82 IVKLAvSQYGSALQFASDSLRNDRDIVLAAVKQNYHAFEYASPILRNDKY 131
                 555542567**********************9998888888888888864 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00046
                 HHHHT-GGGGGHHHHTHHHHHHHHHHTT....T-SBHHHHHHHHH CS
        GLTP  16 lfdllGsafsfvksDvegniekleeaykknpeeystleslveaEk 60 
                  +   Gsa++f+++D+++n e++ +a++++ ++ +   + ++++k
  EFC37455.1 171 AVSNKGSALKFASNDMRNNREIVLKAILQDGNALKFASDSLKSDK 215
                 4556699********************999654444444444443 PP

>> DUF3288  Protein of unknown function (DUF3288)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   0.00011      0.33      10      83 ..     104     173 ..      97     178 .. 0.83
   2 ?   -2.1   0.0       1.3   3.9e+03      26      32 ..     216     222 ..     205     254 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00011
     DUF3288  10 DreivdrLlaeepedenlaelArLliRYegFpGardiqkdldkvlkkWqlteeeLfektreihaekkvykskkd 83 
                 Dr+i   +la+ +++++  e A  ++R +++  + ++++dl+ vlk  +++ ++L   ++++ + ++v+ +  +
  EFC37455.1 104 DRDI---VLAAVKQNYHAFEYASPILRNDKYA-SSELKNDLELVLKVVKINGNNLEFASKKLRKDRRVVLEAVS 173
                 4444...4666778899999999999999986.679**************************999998876655 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.3
     DUF3288  26 nlaelAr 32 
                 +l+e+A 
  EFC37455.1 216 KLIEIAE 222
                 4444442 PP

>> RII_binding_1  RII binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.1   0.00097       2.9       2      14 ..      29      41 ..      28      41 .. 0.88
   2 ?   -0.7   0.2      0.81   2.4e+03      13      19 .]      56      62 ..      55      62 .. 0.79
   3 ?   -2.6   0.0       3.3   9.9e+03       3      10 ..     154     161 ..     153     161 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00097
  RII_binding_1  2 eiEeaanRivslV 14
                    i  +++Rivs+V
     EFC37455.1 29 SIDDYSSRIVSNV 41
                   5889********9 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.81
  RII_binding_1 13 lVIqeAv 19
                   ++I++Av
     EFC37455.1 56 QIISQAV 62
                   7888886 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 3.3
  RII_binding_1   3 iEeaanRi 10 
                    +E+a+ ++
     EFC37455.1 154 LEFASKKL 161
                    89*99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       967  (0.053935); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1581.57
//
Query:       EFC37456.1  [L=574]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.2e-54  184.4   2.4    6.2e-54  183.5   2.4    1.4  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  183.5   2.4   3.5e-58   6.2e-54       2     451 ..      74     549 ..      73     561 .. 0.89

  Alignments for each domain:
  == domain 1  score: 183.5 bits;  conditional E-value: 3.5e-58
                 -SESEHHCCHCHHHHTT.TCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHH.HTTTTSSSTTCGH.HHHHH CS
        p450   2 pgptplplvgnllqlgr.keelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsr.kpfkgkgvlfang.ekwkk 97 
                 pgp+ +pl+g +l++ + +++ + +++kl k+yg+++++ l + + v+ls+p +vkev +++     gr++ + +++ + + ++    + +++ e w+ 
  EFC37456.1  74 PGPKGYPLIGDALEFFKhSQNSQAYFEKLVKEYGEVVKFELLGANNVILSNPIYVKEVAQQDE----GRFYVKGFRQVKlDENMIMAPVEMKPdENWQD 168
                 8999**********98889*****************************************996....444444444422024556666777778***** PP

                 HHHHHHHHHTSH....STT.THHHHHHHHHHHHHHHHHCCCCHCS.....................EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSH. CS
        p450  98 lRrfltptltsf....gkl.sleelveeeaedlveklrkkagess.....................elditellskaaldvigsilFgarfdlledek. 169
                  R++++ +++ +     +l +l++l    +++l+e l+k+ + +s                      +++t+++s++++++++++++ga+f   +++  
  EFC37456.1 169 VRSLFNIAMRPDlsesISLpQLTQLNSGFMNCLIEHLKKTENIQStmnqiqdedfkksianspvfqIVNPTQFISRYTFNAVSKVFLGANFY--DKSLi 265
                 **********99998777899999999***************9999*****************99999*********************965..66654 PP

                 .HHHHHHHHHHHHHHHHCHHHHCCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHCSCSSCSHHHHHHHHC.TTCTCTSSSSHHHHHHH CS
        p450 170 .lselvkaveelssllskssvqllllfpllkylptkllrklkeavkklkdlldklieerretldsakksrrdfldalllak.kekkgesklsdeelaat 266
                  + + + +v++ +++l+     +++++  +kyl  k++ +lk     +++  +++i+   e+  s     +  l+ l+++k ke+    +  +e  + t
  EFC37456.1 266 lPFDRDLFVKDALRFLDIGTRTVFDIPF-FKYLRRKDYLELKTLYVSIIERCKMCINLFTESNPSG----MPRLKELIEEKaKEY----ERGNEMATIT 355
                 44477889********888866666655.9******************************999999....89999****983333....456999999* PP

                 HHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCCTTT.........T-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEE CS
        p450 267 vlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlgdkr.........eptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgyl 356
                 +  +l+aGvd t+ ++++++y +a+  ++qekl+eE+ +v+g+ +          +t ++++kl++ +++i E++Rl +v++++  R+++kd++i gy+
  EFC37456.1 356 LSSFLLAGVDITARVMAITMYRIAHETKYQEKLYEELVKVFGEPSideitngnlLITAEQFKKLKFCRNFIDESMRLNHVIDTSSLRVLSKDLEIAGYK 454
                 *****************************************998899******9****************************9999************* PP

                 E-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTSCTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSC.S CS
        p450 357 ipkGtevivnlyalhrdpevfpnPeeFdpeRFldekgnskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileks.g 451
                 ipkG+ v ++  +  +++++ p+  eF peR+++  +    +++ + PFG G+R C+G r+A+ e+   l++++++F++   + ++ p+++  + +
  EFC37456.1 455 IPKGSFVHFFE-SPKYSEKFIPHSMEFIPERYEKSHECRPINNYVHNPFGLGARKCPGSRVATTEILFSLINIVRHFRLVHENPNEFPKMETDQsM 549
                 *****998765.566779999****************999**************************************986555555554444334 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (574 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       596  (0.0332422); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.28s 00:00:00.95 Elapsed: 00:00:00.47
# Mc/sec: 3696.68
//
Query:       EFC37457.1  [L=554]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (554 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       609  (0.0339673); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 3436.00
//
Query:       EFC37458.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-19   68.4   0.0    8.2e-19   67.7   0.0    1.3  1  GST_N     Glutathione S-transferase, N-terminal domain
    2.4e-18   66.3   0.0    3.9e-18   65.6   0.0    1.3  1  GST_N_3   Glutathione S-transferase, N-terminal domain
    6.5e-16   58.4   0.0    9.7e-16   57.8   0.0    1.3  1  GST_N_2   Glutathione S-transferase, N-terminal domain
    1.9e-14   53.6   0.0    2.4e-14   53.3   0.0    1.3  1  GST_C     Glutathione S-transferase, C-terminal domain
    8.5e-06   25.9   0.0    1.6e-05   25.0   0.0    1.4  1  GST_C_3   Glutathione S-transferase, C-terminal domain
     0.0015   18.6   0.0     0.0026   17.7   0.0    1.4  1  GST_C_2   Glutathione S-transferase, C-terminal domain


Domain annotation for each model (and alignments):
>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.7   0.0   2.7e-22   8.2e-19       1      75 [.       1      75 [.       1      76 [. 0.97

  Alignments for each domain:
  == domain 1  score: 67.7 bits;  conditional E-value: 2.7e-22
                EEEEEESSSTSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTTS-SSEEEETTEEEESHHHHHHHHH CS
       GST_N  1 avltlysirgsprahrirlllaakgveyevvpldfeageekspellklnplgkvPaLedngkkltESraIleYia 75
                +v++ y++ +s  + r++ ++++kg+e+e vp+d+ +ge+ksp +l ++p+g +P+Led+g+ + ESraI++Y++
  EFC37458.1  1 MVYKIYGAAQSTCVQRVLTTIKEKGLEFELVPVDLMKGEHKSPSYLEKHPFGVIPVLEDDGFLIYESRAICRYLE 75
                68999********************************************************************96 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.6   0.0   1.3e-21   3.9e-18       2      72 ..       6      79 ..       5      83 .. 0.92

  Alignments for each domain:
  == domain 1  score: 65.6 bits;  conditional E-value: 1.3e-21
                ES-TTSHHHHHHHHHHHHHT--EEEE---..TTTT.HHHHHHH-TT--SSEEETTS-EEESHHHHHHHHHHHH- CS
     GST_N_3  2 ygfpaSpyarrvrlaLnekglpvevvevt..pgeh.deellaknplgkvPvLeddgealtdSlaIidyLeelyp 72
                yg+  S  ++rv  +++ekgl++e+v+v+  +geh ++++l+k+p g +PvLeddg  +++S+aI++yLe ++ 
  EFC37458.1  6 YGAAQSTCVQRVLTTIKEKGLEFELVPVDlmKGEHkSPSYLEKHPFGVIPVLEDDGFLIYESRAICRYLEAKHK 79
                8899999******************88865588888**********************************9996 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.8   0.0   3.2e-19   9.7e-16       2      69 ..      11      76 ..      10      77 .. 0.95

  Alignments for each domain:
  == domain 1  score: 57.8 bits;  conditional E-value: 3.2e-19
                -HHHHHHHHHHHHCT--EEEEEEH...-TTSHHHHHHHHCTTTSSSEEE-CTTEEEESHHHHHHHHHH CS
     GST_N_2  2 CPwahRvlialalkglediisvvvlepkgfekseefprlnprgtVPvLwdkdgqvineSseIlrylet 69
                + +++Rvl ++++kgle+++ +v+l+ kg++ks+ +++ +p+g +PvL d dg  i+eS++I+ryle+
  EFC37458.1 11 STCVQRVLTTIKEKGLEFELVPVDLM-KGEHKSPSYLEKHPFGVIPVLED-DGFLIYESRAICRYLEA 76
                6799*******************776.99********************9.9**************96 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.3   0.0   7.9e-18   2.4e-14      18      93 .]     128     203 ..      56     203 .. 0.90

  Alignments for each domain:
  == domain 1  score: 53.3 bits;  conditional E-value: 7.9e-18
                 HHHHHHHHHHHHHHHHHHHHHHHHHHTSSSSSTTSSCHHHHHHHHHHHHHHHHTTTTTTTTSHHHHHHHHHHHTSH CS
       GST_C  18 ekkeelvdealekvaevlsaleeelkkqdylvGdkltlADialvpilnwlqrlglafgqekfpnlkawlerimarp 93 
                 + +e+ v++++ek+   l+a+e +l+kq ++ G+++tlAD++++p  n l+ +gl+ +  + p++kaw+e+i++rp
  EFC37458.1 128 AADEARVKQLSEKLSLNLDAYERVLAKQEFIGGNQFTLADLYHLPYGNLLFAIGLGNLLLDRPHVKAWWEKISSRP 203
                 77999*************************************************99888****************9 PP

>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.0   5.2e-09   1.6e-05      19      93 ..     131     206 ..     114     209 .. 0.80

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 5.2e-09
                 HHHHHHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHH...TCCCC-HHHHHHHHHHHTSHHHH CS
     GST_C_3  19 ekkkefleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleea...ealkkfpklkalyervearpkik 93 
                 e++ + l e+l   l+++e+vl+  +++++ g+++T+ADl  + + + l  +   + l + p++ka++e++++rp+ k
  EFC37458.1 131 EARVKQLSEKLSLNLDAYERVLA--KQEFIGGNQFTLADLYHLPYGNLLFAIglgNLLLDRPHVKAWWEKISSRPSWK 206
                 7778888999999**********..999************888865555555775444789**************865 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   8.8e-07    0.0026       4      66 ..     134     195 ..     131     198 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 8.8e-07
                 HCHHHHHCCHCHHHCTTT---SS.CTTCS--HHHHHHHHHHHHHHHHHHS----TT-HHHHHH CS
     GST_C_2   4 veraleqldaaldaleahLadspflfGdqptlaDialapflvrlraagpgfdireaypnlraW 66 
                 v+++ e+l   lda e+ La++ f++G+q+tlaD    p    l a+g g  +  + p+++aW
  EFC37458.1 134 VKQLSEKLSLNLDAYERVLAKQEFIGGNQFTLADLYHLPYGNLLFAIGLGN-LLLDRPHVKAW 195
                 555566666679999*******************98888888888888664.44466777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       419  (0.02337); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 1182.14
//
Query:       EFC37459.1  [L=624]
Description: serine/threonine protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.5e-28   99.9   1.1    2.8e-28   99.0   1.1    1.4  1  Pkinase      Protein kinase domain
    5.4e-20   71.8   0.1    9.3e-20   71.0   0.1    1.4  1  Pkinase_Tyr  Protein tyrosine kinase
    7.5e-07   29.4   0.7    1.8e-06   28.2   0.7    1.8  1  C2           C2 domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.0   1.1   4.6e-32   2.8e-28      15     260 ..     356     611 ..     350     613 .. 0.85

  Alignments for each domain:
  == domain 1  score: 99.0 bits;  conditional E-value: 4.6e-32
                 EEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.........SSEEEEEEE--TTEBHHHHHH....HHSS--HHHH CS
     Pkinase  15 VykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.........kdelylvleyveggeladlle....rkgslseeea 100
                  yk+++ + +k   +Kkik e + + ++  +++E   l +l+ ++++ + ++f +            ++ v+ + ++g+l d++     ++ +l+ +++
  EFC37459.1 356 LYKIMDLKFNKAKILKKIKCETIMNAND--AIKESWPLLELQFDHLISYEDMFIDittneilgsIFFVCYVTPFYDEGSLYDFMCkvkkKNIHLTLRRI 452
                 5788888888888899999998888776..*************************999888765445567999******99988777656667999*** PP

                 HHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS...BCTTTSCGGGS-HHHH...TTSCBSHHHHHHHHHHHHHHHHHS CS
     Pkinase 101 kkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtseYlAPEvl...keneyskkvDvWslGvilyelltg 193
                 +++a qi++g+++lH+++i+Hr lKp+Ni +     l  t FG+ak ++++ +     + ++   Y APE+    + + y+ +vD+Ws G+ilyellt 
  EFC37459.1 453 SDYALQIAKGVQFLHDHSIMHRSLKPNNIYFG----LSNTNFGFAKAINNTLSiigGITKIVNFGYTAPEIAlvnDVSVYGFEVDIWSFGIILYELLTL 547
                 *******************************9....77799**********999997788999*******9888777899******************9 PP

                 S-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 194 kppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellq 260
                 k    + ++   ++ + d+   + ++++  +     +++  ee+++ll+k+l  dpk+R+ a++l+q
  EFC37459.1 548 KIDKDQLNHAYLASYNRDT--YMKNVIEG-EIRKIYKNDAAEEFIQLLRKILVIDPKSRIIASDLVQ 611
                 9888866665555555555..55666654.44555566779*********************99987 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.0   0.1   1.6e-23   9.3e-20      34     259 .]     371     613 ..     357     613 .. 0.79

  Alignments for each domain:
  == domain 1  score: 71.0 bits;  conditional E-value: 1.6e-23
                  EEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE..SSSS.......EEEEEE--TTEBHHHHHHHT..CTTTSBHHHHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr  34 Ktlkeeateeekeelleeakimkklkhpnivkllgvct..keep.......llivteyvkgGdLlkfLrkk..ekekltlkdllsfalqvAkGmeyLe 120
                  K++k e+  +  ++ ++e   + +l+ ++++++  + +   +++       ++ vt + ++G+L +f+ k   ++ +ltl+++ ++alq+AkG+++L+
   EFC37459.1 371 KKIKCETIMN-ANDAIKESWPLLELQFDHLISYEDMFIdiTTNEilgsiffVCYVTPFYDEGSLYDFMCKVkkKNIHLTLRRISDYALQIAKGVQFLH 467
                  5554444444.5666777777777777788877777764422224666677899**************8762245678999***************** PP

                  HTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE...EEHHHHHHHHHHHHHHHHTTSSGT.......TTT CS
  Pkinase_Tyr 121 skklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk...ftsksDvWsfGvllwEiftlgesp.......ypg 208
                  +++++Hr l   N+    ++    + fG a++i+++ +     ++ +++ ++apE+   +    +  + D+WsfG++l+E++tl  +        +++
   EFC37459.1 468 DHSIMHRSLKPNNIYFGLSN----TNFGFAKAINNTLSIIGGITKIVNFGYTAPEIALVNDvsvYGFEVDIWSFGIILYELLTLKIDKdqlnhayLAS 561
                  ***************99555....79*******9998999999999*********8765553569999***************876556777775445 PP

                  SHHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 209 lkneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                  ++  + ++++ + + r    +++ ee+ +l++k +  dp++R   s+lv++l
   EFC37459.1 562 YNRDTYMKNViEGEIRKIYKNDAAEEFIQLLRKILVIDPKSRIIASDLVQEL 613
                  555555555526667777888899*******************999999876 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   0.7     3e-10   1.8e-06      33      98 ..     182     254 ..     128     259 .. 0.88

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 3e-10
                 EEEEEE-SCSSSSSSEEEEEEEEEESC........HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHHHH CS
          C2  33 kqkakTrviknslnPvWnekftfevae........leeakLeveVfdndrlskddfiGkveiplstllsgeeae 98 
                  ++ k++ i+++ +PvWne f f+++           ++ + ++V+ +++++ d+++G+ +i+l+tll+++e  
  EFC37459.1 182 RRTLKSNAIRST-SPVWNELFIFDIHVtnnndqkyVIHENIIMQVWAKHTFKTDELLGVKNINLQTLLRNRENP 254
                 566788888999.9*********999988998887788999*************************88877655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (624 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1212  (0.0676); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 3678.39
//
Query:       EFC37460.1  [L=274]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-56  190.6   0.6    3.1e-56  190.1   0.6    1.1  1  DUF4291   Domain of unknown function (DUF4291)


Domain annotation for each model (and alignments):
>> DUF4291  Domain of unknown function (DUF4291)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  190.1   0.6   1.7e-60   3.1e-56       2     179 ..      53     256 ..      52     257 .. 0.88

  Alignments for each domain:
  == domain 1  score: 190.1 bits;  conditional E-value: 1.7e-60
     DUF4291   2 iralydeetitvYQAykaeiaeaavkaqkfeaspefkteRmtWiKpsflWmlyRsgyatkknQeriLaikikregf.eelLekavlssaekeleeeke. 98 
                 i++  dee+i++YQAy++ ia+++vk+q+f+++p+f+++Rm+WiKp++lWm+yRs+yat+knQ++iLa+ i+r++f eelL++av++++ +ele   + 
  EFC37460.1  53 IITIDDEECIVFYQAYNSGIADWVVKNQTFDECPNFDKKRMSWIKPNYLWMMYRSEYATAKNQTNILALFITRKSFeEELLKHAVCAMYYPELEGYYKs 151
                 88999***********************************************************************7789**********998765544 PP

     DUF4291  99 ..ewkkelkksk......................vrvQWdperdlrleklek...rsiqiGlkgelvkkyve.ewivsiedvtekvrelkk.llkedel 168
                   ewk +++++k                      +rvQWdp +++++++++    r+iqiG+kg++++++++  ++++ied+t++v+e+++ +lk+++ 
  EFC37460.1 152 qkEWKVNCSQMKekvaqlmnkndtdtimtdnvcfARVQWDPYHTPAFGNINGgltRAIQIGVKGSFLRSMCKsGACKKIEDITKYVHEQHAeYLKTKD- 249
                 4488888888866677777778888888889999*****************7777****************957899************983453333. PP

     DUF4291 169 eevkellpeer 179
                   +  l+p+er
  EFC37460.1 250 --L--LIPVER 256
                 ..3..777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1890.58
//
Query:       EFC37461.1  [L=108]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (108 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 646.65
//
Query:       EFC37462.1  [L=689]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-20   73.8   0.3      6e-20   71.7   0.2    2.2  2  ARID      ARID/BRIGHT DNA binding domain
     0.0009   19.3   1.6     0.0037   17.3   0.2    2.4  2  DUF4211   Domain of unknown function (DUF4211)
  ------ inclusion threshold ------
        0.2   10.9   3.3        1.6    8.0   0.1    2.9  3  BAF250_C  SWI/SNF-like complex subunit BAF250/Osa


Domain annotation for each model (and alignments):
>> ARID  ARID/BRIGHT DNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.7   0.2     1e-23     6e-20       1      90 []      28     116 ..      28     116 .. 0.94
   2 ?   -2.4   0.0       1.4   8.3e+03       4      19 ..     515     530 ..     514     547 .. 0.77

  Alignments for each domain:
  == domain 1  score: 71.7 bits;  conditional E-value: 1e-23
                 HHHHHHHHHHHHHHHTTS.S..SS----SSSS-STTHHHHHHTTTSSHHHHTT.CHHHHHHHHHTS-..-.......HHHHHHHHHHHHHHHH CS
        ARID   1 ekeeFlstLkqfhenrgt.l..kkiPviggkevdlykLyraVikrGGfrkvtqknkWeevaqklglpredpeasesvaqalksiYeryLlpyE 90 
                 e+++F++++++f+e+rgt +  +++P++gg+++++ykL+ +V  rGG+++v+++++W+ev +  ++p+ +  ++ s++++lk +Y+++L+ +E
  EFC37462.1  28 ERDKFYREVNEFMEKRGTpIphDNLPQLGGRRLNVYKLWLQVWGRGGYEAVCENKQWTEVRDSYQVPK-T--CT-SASYSLKMYYQKWLYSFE 116
                 5899**************758999****************************99************85.3..76.99***************9 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHHTTSS CS
        ARID   4 eFlstLkqfhenrgtl 19 
                 +Fls+L +f +n + l
  EFC37462.1 515 NFLSKLVEFTNNTQLL 530
                 799******9987655 PP

>> DUF4211  Domain of unknown function (DUF4211)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.2   6.2e-07    0.0037       4     114 ..     464     572 ..     456     582 .. 0.82
   2 ?   -0.2   0.1      0.16   9.3e+02     104     131 ..     622     648 ..     618     654 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 6.2e-07
     DUF4211   4 vededeelgapdeeeeedelplefsskahkdlkehFkdvvewlvsnaldpdfllafeerkdelylvalkkldde..vegladslvsssaWkpefkkaLe 100
                 + +e++ +g+p++e+e++e ++e+ + ++++ k+   +   + + +++++    +f  +k  ++ ++ + l++   ++g+ d+l++  +Wk++ ++++e
  EFC37462.1 464 DYEEEKVEGEPEDEDETNENKEEIQTVEKQKQKSLTSRLTDIELLCRMSSI---NF-LSKLVEFTNNTQLLETIsaCNGCIDKLITLIVWKSNLYNRIE 558
                 444555699999888899999999778888888888888888888888888...33.55558999999999988779********************** PP

     DUF4211 101 arPelditelease 114
                 ++P+l +++++++e
  EFC37462.1 559 QYPYLILQQVKENE 572
                 *****999999876 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.16
     DUF4211 104 elditeleaseekkCdAcnrskhpatys 131
                   d++ +++s+ k+Cd+ + +k++a++ 
  EFC37462.1 622 TDDSNMVDESK-KGCDSLKFQKKCASIL 648
                 55677778887.************9875 PP

>> BAF250_C  SWI/SNF-like complex subunit BAF250/Osa
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0      0.75   4.5e+03     182     227 ..     254     300 ..     253     315 .. 0.71
   2 ?    8.0   0.1   0.00026       1.6       4      45 ..     323     364 ..     320     377 .. 0.87
   3 ?    2.3   0.1     0.015        88     184     235 ..     506     559 ..     486     576 .. 0.69

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 0.75
    BAF250_C 182 redqvlrElavvlLsalaqadeavaraial.qkssislLisFiedae 227
                 +edq l+E a+  +  l+q ++  +  i +    +   L+++  + e
  EFC37462.1 254 SEDQNLKEWALYQVLRLSQFETFRCHHIPTlVDVCEEYLLDYATQVE 300
                 68999999999999999999888887775413445566666655554 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00026
    BAF250_C   4 kRclcvSnilRsLsfvpgndtelakhkalllilgrllllhhe 45 
                 +++  v ++lR+ sf+p n+ ++ k+++l+ il  +l+ + +
  EFC37462.1 323 HKAFMVITLLRNASFLPDNQPSIGKSNSLMDILVFFLRNNIN 364
                 67888999************************9988887665 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.015
    BAF250_C 184 dqvlrElavvlLsalaq..adeavaraialqkssislLisFiedaeakaravae 235
                 +  +r  +++ Ls+l++   +++++ +i+  + +i +Li+ i   ++  +++ +
  EFC37462.1 506 ELLCRMSSINFLSKLVEftNNTQLLETISACNGCIDKLITLIVWKSNLYNRIEQ 559
                 457888899999999975466778999999999999999998665555554444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (689 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1297  (0.0723409); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 4028.86
//
Query:       EFC37463.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      2e-31  110.1   0.4    3.1e-31  109.5   0.4    1.3  1  Metallophos  Calcineurin-like phosphoesterase
    1.3e-20   73.5   0.8    2.1e-20   72.8   0.8    1.4  1  PPP5         PPP5 TPR repeat region


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.5   0.4   3.5e-35   3.1e-31       2     202 ..      85     279 ..      84     281 .. 0.85

  Alignments for each domain:
  == domain 1  score: 109.5 bits;  conditional E-value: 3.5e-35
                  EEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSSHHHHHHHHH.HHHHHHHTSEEEEEC-TTS........CHHHHHHHHHHHHHH CS
  Metallophos   2 rilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrgdlekellel.laalvkypipvylllGNHe........gfeeellnkygylgi 90 
                  +i+v+gD+H     gq++dllk+++   r++k + +l++GD+vdrg++++e++   la++++ p   yl++GNHe        gfe e   ky     
   EFC37463.1  85 HITVCGDTH-----GQYYDLLKIFELNGRPSKENPFLFNGDFVDRGSFSCEVIFTlLAYKLHDPECMYLTRGNHEsrhlnqiyGFEAETVKKYN---- 173
                  699******.....**********999777788888888***********99999899999977777********8777765555555555544.... PP

                  HHHHHEHHHCEEETSEEEEEETTEEEEEEEESECEEE...THHHHHHHHHHHSCHHHHCC...HHHHHHHHHHTTCSEEEEEESSESSCSSSCSCCHH CS
  Metallophos  91 fsepwrsdaevfnnlplaslgsgslkvlllhGgspel...lvsldklgslnleleapepg...dewlkdlekrekadwvivlgHsplyrgsgylfgde 182
                   +e+++ ++evfn+lpla+ ++   kvl+lhGg +++    v+l++++++++ +++pe+g   d++++d        +  + g   + rg + +fg++
   EFC37463.1 174 -GEVYELFQEVFNYLPLACVINS--KVLVLHGG-IGFkepGVTLQDIENIDRMRDIPEDGlmcDILWSD--------PQKLNGLGLNKRGVSRVFGPD 259
                  .6778888***************..********.33355678***************************........55555544444********** PP

                  HHHHHHHHTTESEEEEESSS CS
  Metallophos 183 aledllkkygvdlvisGHtH 202
                  +++++l+++g+ l i++H+ 
   EFC37463.1 260 VTKKFLDDNGLELLIRSHEV 279
                  ******************96 PP

>> PPP5  PPP5 TPR repeat region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.8   0.8   2.4e-24   2.1e-20      15      93 ..       2      76 ..       1      77 [. 0.93

  Alignments for each domain:
  == domain 1  score: 72.8 bits;  conditional E-value: 2.4e-24
        PPP5 15 kAIeveekesasetldlesieveksYdGprLeeeeekitqeFvkamierfkkgkklhkkyvyaillkvkellkkepslv 93
                +AI  + k ++se+++++ i+ve+sYdG+rL    e it+eFv++m+erfk++kk+h ky+++il+ + +llk+e+sl 
  EFC37463.1  2 EAIG-GTKTHISEEINYNVIDVEESYDGVRL---GEVITKEFVEDMVERFKNQKKIHIKYAMEILVMASKLLKNEKSLF 76
                5774.45889*********************...789****************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 2250.65
//
Query:       EFC37464.1  [L=252]
Description: leucine-rich repeat protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-44  145.1  13.6    0.00041   20.2   0.0   10.4 10  LRR_6     Leucine Rich repeat
      1e-27   95.7   5.3    6.9e-08   32.1   0.3    5.0  5  LRR_8     Leucine rich repeat
    2.1e-21   75.7  11.1    0.00055   20.3   1.7    6.9  8  LRR_4     Leucine Rich repeats (2 copies)
    2.7e-14   51.5   0.3       0.55   11.0   0.0    8.4  9  LRR_1     Leucine Rich Repeat
    2.4e-05   23.9   0.2        2.4    7.6   0.0    3.1  3  LRR_9     Leucine-rich repeat
     0.0003   20.7   4.1         12    5.7   0.2    5.5  5  DUF4347   Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
      0.017   15.2   0.4        3.5    7.8   0.0    3.4  4  NKWYS     Putative capsular polysaccharide synthesis protein
       0.15   12.6   2.3        6.7    7.2   0.2    3.6  4  NOC3p     Nucleolar complex-associated protein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   0.00024      0.53       5      24 .]       4      23 ..       2      23 .. 0.92
   2 !   18.9   0.1   4.7e-07     0.001       5      20 ..      28      43 ..      25      47 .. 0.91
   3 !   20.2   0.0   1.8e-07   0.00041       5      24 .]      52      71 ..      49      71 .. 0.94
   4 !   16.8   0.0   2.2e-06    0.0049       5      23 ..      76      94 ..      73      95 .. 0.91
   5 !    7.0   0.0    0.0031         7       4      23 ..      99     118 ..      97     119 .. 0.88
   6 !   20.0   0.1   2.1e-07   0.00047       5      24 .]     124     143 ..     121     143 .. 0.93
   7 !   15.4   0.0   6.5e-06     0.014       5      24 .]     148     167 ..     146     167 .. 0.90
   8 !   12.4   0.0   5.6e-05      0.13       5      24 .]     172     191 ..     169     191 .. 0.93
   9 !    6.2   0.0    0.0057        13      11      23 ..     202     214 ..     194     215 .. 0.78
  10 !   16.3   0.1   3.3e-06    0.0074       5      23 ..     220     238 ..     217     238 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00024
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt Ld+ +N++g eGa++++
  EFC37464.1  4 LTLLDIYCNQVGVEGAKSIS 23
                889**************996 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 4.7e-07
       LRR_6  5 LteLdLsgNdIgDeGa 20
                Lt+L++s N+IgD+Ga
  EFC37464.1 28 LTSLNISNNEIGDKGA 43
                9**************8 PP

  == domain 3  score: 20.2 bits;  conditional E-value: 1.8e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++ +N++g+eGa++++
  EFC37464.1 52 LTSLNIGSNKFGNEGAKSIS 71
                9****************996 PP

  == domain 4  score: 16.8 bits;  conditional E-value: 2.2e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt L +  N+IgDeG++ +
  EFC37464.1 76 LTVLYIGLNQIGDEGVKFI 94
                9***************977 PP

  == domain 5  score: 7.0 bits;  conditional E-value: 0.0031
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt++d+ +N+Ig +Ga ++
  EFC37464.1  99 RLTSVDICYNGIGVKGANSI 118
                 59**************9766 PP

  == domain 6  score: 20.0 bits;  conditional E-value: 2.1e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+  N+IgDeGa++++
  EFC37464.1 124 LTSLDICLNQIGDEGAKSIS 143
                 9****************996 PP

  == domain 7  score: 15.4 bits;  conditional E-value: 6.5e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L +s N+IgDeGa++++
  EFC37464.1 148 LTLLYISANQIGDEGAKSIS 167
                 788999***********996 PP

  == domain 8  score: 12.4 bits;  conditional E-value: 5.6e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L +s N+Ig +Gae+++
  EFC37464.1 172 LTSLAISANQIGVKGAESIS 191
                 9****************996 PP

  == domain 9  score: 6.2 bits;  conditional E-value: 0.0057
       LRR_6  11 sgNdIgDeGaeaL 23 
                 s N+Ig eG++ +
  EFC37464.1 202 SANQIGAEGVKFI 214
                 66********977 PP

  == domain 10  score: 16.3 bits;  conditional E-value: 3.3e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+  N Ig eG++ L
  EFC37464.1 220 LTSLDIGNNRIGAEGVTLL 238
                 9**************9876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.3   3.1e-11   6.9e-08       2      61 .]       3      62 ..       2      62 .. 0.97
   2 !   15.6   0.2   4.3e-06    0.0097       2      37 ..      51      86 ..      50      89 .. 0.94
   3 !   30.1   0.0   1.4e-10   3.1e-07       2      61 .]      99     158 ..      98     158 .. 0.98
   4 !   18.6   0.0   5.1e-07    0.0011      20      61 .]     165     206 ..     160     206 .. 0.94
   5 !    9.3   0.1   0.00042      0.94      24      53 ..     217     246 ..     210     248 .. 0.57

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 3.1e-11
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +Lt Ld+ +N+  + + ++ + +++L++L++snN++    ++ +sg+++L+sL++ +N++
  EFC37464.1  3 QLTLLDIYCNQVGVEGAKSISEMKQLTSLNISNNEIGDKGANFISGMKQLTSLNIGSNKF 62
                799*******************************************************85 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 4.3e-06
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37
                +LtsL++ +N++ + + ++ + +++L+vL+++ N++
  EFC37464.1 51 QLTSLNIGSNKFGNEGAKSISEMKQLTVLYIGLNQI 86
                79********************************98 PP

  == domain 3  score: 30.1 bits;  conditional E-value: 1.4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lts+d++ N + + +  + + +++L++Ld+  N++    ++++s L++L+ L++s N++
  EFC37464.1  99 RLTSVDICYNGIGVKGANSISEMKQLTSLDICLNQIGDEGAKSISELEQLTLLYISANQI 158
                 8*********************************************************98 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 5.1e-07
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + + l++L++L +s N++ +  ++++s L++L+sL  s N++
  EFC37464.1 165 SISELKQLTSLAISANQIGVKGAESISELKQLTSLAASANQI 206
                 67789***********************************97 PP

  == domain 5  score: 9.3 bits;  conditional E-value: 0.00042
                 -TT--EEE--SS---GGGGGGGTT--S-.E CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrs 53 
                 +++L++Ld++nN++       + +L+sL++
  EFC37464.1 217 MKQLTSLDIGNNRIGAEGVTLLTSLTSLKF 246
                 666666666666665555555555555554 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.2   1.9e-06    0.0042       1      38 [.       2      40 ..       2      42 .. 0.79
   2 !   20.3   1.7   2.4e-07   0.00055       1      35 [.      26      61 ..      26      66 .. 0.81
   3 !   13.9   0.0   2.5e-05     0.055       1      33 [.      74     108 ..      74     121 .. 0.86
   4 !    9.8   0.1   0.00048       1.1       1      38 [.      98     136 ..      98     146 .. 0.72
   5 !   15.0   0.1   1.1e-05     0.024       1      38 [.     122     160 ..     122     163 .. 0.85
   6 !   14.1   0.1   2.2e-05     0.049       2      37 ..     147     188 ..     146     195 .. 0.78
   7 ?    4.9   0.0     0.017        39       2      36 ..     171     206 ..     170     208 .. 0.61
   8 !   16.7   0.1   3.3e-06    0.0074       2      37 ..     195     231 ..     194     245 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.9e-06
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38
                ++L+ Ld+  Nq+   +   ++ +++L++L++s+N  i+d
  EFC37464.1  2 KQLTLLDIYCNQVGVEGAksISEMKQLTSLNISNN-EIGD 40
                5799*****99*99766675445*********555.7765 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 2.4e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35
                ++L++L++snN + d +   ++++++L++L++ +N +
  EFC37464.1 26 KQLTSLNISNNEIGDKGAnfISGMKQLTSLNIGSN-K 61
                58************866684446*********666.4 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 2.5e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgN 33 
                 ++L+vL+++ Nq+ d +  + + ++ L+++d+  N
  EFC37464.1  74 KQLTVLYIGLNQIGDEGVkFISeMKRLTSVDICYN 108
                 58*******88****99996655********9777 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00048
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38 
                 ++L+++d+  N +  + +   ++ +++L++Ld+   n+i+d
  EFC37464.1  98 KRLTSVDICYNGIG-VKGansISEMKQLTSLDI-CLNQIGD 136
                 57999999999977.334243445********9.4347755 PP

  == domain 5  score: 15.0 bits;  conditional E-value: 1.1e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+  Nq+ d +   ++ l +L+ L++s N +i+d
  EFC37464.1 122 KQLTSLDICLNQIGDEGAksISELEQLTLLYISAN-QIGD 160
                 58*******88****99986445*********988.8876 PP

  == domain 6  score: 14.1 bits;  conditional E-value: 2.2e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---.....- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli.....t 37 
                 +L+ L++s Nq+ d +   ++ l++L++L +s N +i     +
  EFC37464.1 147 QLTLLYISANQIGDEGAksISELKQLTSLAISAN-QIgvkgaE 188
                 6999****88****99986445*********988.88555445 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.017
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 +L++L +s Nq+  + +   ++ l++L++L  s N +i
  EFC37464.1 171 QLTSLAISANQIG-VKGaesISELKQLTSLAASAN-QI 206
                 7999999977877.334232334888877754555.55 PP

  == domain 8  score: 16.7 bits;  conditional E-value: 3.3e-06
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 +L++L  s Nq+   +  + + +++L++Ld+ gNn+i+
  EFC37464.1 195 QLTSLAASANQIGAEGVkFISeMKQLTSLDI-GNNRIG 231
                 7999999977999666685555*********.888884 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.84   1.9e+03       2      20 ..       4      22 ..       3      25 .. 0.75
   2 !   11.0   0.0   0.00024      0.55       1      22 [.      27      48 ..      27      49 .. 0.89
   3 !    6.4   0.0    0.0078        17       1      21 [.      51      71 ..      51      73 .. 0.86
   4 ?    0.5   0.0      0.67   1.5e+03       2      16 ..      76      90 ..      75      97 .. 0.76
   5 ?    5.6   0.0     0.014        31       1      21 [.      99     119 ..      99     121 .. 0.91
   6 ?    4.7   0.0     0.028        63       1      23 []     123     145 ..     123     145 .. 0.89
   7 ?    3.3   0.0     0.083   1.9e+02       2      23 .]     148     169 ..     147     169 .. 0.88
   8 ?   -0.2   0.0       1.2   2.6e+03       2      23 .]     172     193 ..     171     193 .. 0.84
   9 !    6.6   0.1    0.0068        15       1      13 [.     219     234 ..     219     249 .. 0.71

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.84
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                L+ Ld+  n+ +  ++ s+
  EFC37464.1  4 LTLLDIYCNQVGVEGAKSI 22
                899***9998766666665 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00024
       LRR_1  1 nLrhLdLsnnpllglppnsfqn 22
                +L++L++snn ++++++n +++
  EFC37464.1 27 QLTSLNISNNEIGDKGANFISG 48
                599************9998876 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0078
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++L++++n +++ ++ s++
  EFC37464.1 51 QLTSLNIGSNKFGNEGAKSIS 71
                599********9998888876 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.67
       LRR_1  2 LrhLdLsnnpllglp 16
                L++L+++ n++++ +
  EFC37464.1 76 LTVLYIGLNQIGDEG 90
                99****999986655 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++ d+++n ++ +++ns++
  EFC37464.1  99 RLTSVDICYNGIGVKGANSIS 119
                 699***************997 PP

  == domain 6  score: 4.7 bits;  conditional E-value: 0.028
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++Ld++ n++++ ++ s++ L
  EFC37464.1 123 QLTSLDICLNQIGDEGAKSISEL 145
                 599*********99999999865 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.083
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ L++s n++++ ++ s++ L
  EFC37464.1 148 LTLLYISANQIGDEGAKSISEL 169
                 899********99999999865 PP

  == domain 8  score: -0.2 bits;  conditional E-value: 1.2
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L++L +s n+++ ++++s++ L
  EFC37464.1 172 LTSLAISANQIGVKGAESISEL 193
                 8899999999999999998865 PP

  == domain 9  score: 6.6 bits;  conditional E-value: 0.0068
       LRR_1   1 nLrhLdLsnnpl...l 13 
                 +L++Ld++nn++   +
  EFC37464.1 219 QLTSLDIGNNRIgaeG 234
                 599*******985540 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0    0.0014       3.1      61     124 ..      23      85 ..       3     105 .. 0.77
   2 !    7.6   0.0    0.0011       2.4      56     126 ..     114     183 ..      95     188 .. 0.75
   3 ?    4.0   0.0     0.014        32      58      94 ..     212     248 ..     191     251 .. 0.56

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0014
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                   +k+l +l ++nn i   + ++   + +l++l + +n++ + +  + + ++k+l++l +  n 
  EFC37464.1  23 SEMKQLTSLNISNNEIGDKGANFISGMKQLTSLNIGSNKFGNEGA-KSISEMKQLTVLYIGLNQ 85 
                 557888888888888888888888888888888888888887776.778888888877665554 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0011
       LRR_9  56 kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                   +++  +k+l +l +  n+i   + +    l +l+ l ++ n++ + +  + + +lk+l++l++  n + 
  EFC37464.1 114 GANSISEMKQLTSLDICLNQIGDEGAKSISELEQLTLLYISANQIGDEGA-KSISELKQLTSLAISANQIG 183
                 45566677888888888888777777666777777788888999998887.89999999999999988775 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.014
       LRR_9  58 dgfPllkrlktlllnnnrivriaegleevlPnleelv 94 
                   +  +k+l +l + nnri   +  l  +l +l+ lv
  EFC37464.1 212 KFISEMKQLTSLDIGNNRIGAEGVTLLTSLTSLKFLV 248
                 3334466777777888888777777766666666665 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.033        73     103     122 ..      39      58 ..       2      70 .. 0.78
   2 ?    3.3   0.0      0.03        68     102     121 ..      86     105 ..      67     117 .. 0.83
   3 ?   -0.8   0.0      0.53   1.2e+03      98     122 ..     106     130 ..     105     148 .. 0.81
   4 !    5.7   0.2    0.0052        12      92     125 ..     148     181 ..     115     189 .. 0.76
   5 ?    4.2   0.1     0.016        36     103     121 ..     207     225 ..     187     235 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.033
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +f++ ++qlt  ++ 
  EFC37464.1  39 GDKGANFISGMKQLTSLNIG 58 
                 57788888888888888875 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.03
     DUF4347 102 ageaGeafvekLaqltgadv 121
                  g++G +f++++++lt +d+
  EFC37464.1  86 IGDEGVKFISEMKRLTSVDI 105
                 5899*************998 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.53
     DUF4347  98 CnvAageaGeafvekLaqltgadva 122
                 C  + g +G + +++++qlt  d+ 
  EFC37464.1 106 CYNGIGVKGANSISEMKQLTSLDIC 130
                 6667788999999999999999985 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.0052
     DUF4347  92 dillYgCnvAageaGeafvekLaqltgadvaAst 125
                   llY      g++G + +++L+qlt   ++A++
  EFC37464.1 148 LTLLYISANQIGDEGAKSISELKQLTSLAISANQ 181
                 34778888888999************99999974 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.016
     DUF4347 103 geaGeafvekLaqltgadv 121
                 g++G +f+++++qlt  d+
  EFC37464.1 207 GAEGVKFISEMKQLTSLDI 225
                 4679999999999999998 PP

>> NKWYS  Putative capsular polysaccharide synthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.18     4e+02      40      78 ..      24      62 ..      21      83 .. 0.57
   2 ?    1.9   0.0     0.098   2.2e+02      40      87 ..      48      96 ..      42     107 .. 0.76
   3 ?    7.8   0.0    0.0015       3.5      40      96 ..     120     177 ..     118     200 .. 0.86
   4 ?    0.1   0.0      0.36   8.2e+02      37      57 ..     213     233 ..     211     248 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.18
       NKWYS 40 ElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekl 78
                E+k+++++++ n+++ ++   +i   k+   l i s+k 
  EFC37464.1 24 EMKQLTSLNISNNEIGDKGANFISGMKQLTSLNIGSNKF 62
                677777777777777666555555555555444444444 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.098
       NKWYS 40 ElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikd 87
                 +k+++++++  ++f ++    i + k+  +l i  +++ +   k i +
  EFC37464.1 48 GMKQLTSLNIGSNKFGNEGAKSISEMKQLTVLYIGLNQIGDEgVKFISE 96
                5799999999999999999999999999999999888775544555555 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0015
       NKWYS  40 ElkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikdfLnidnvkl 96 
                 E+k+++++D+  +++ ++    i + ++  ll i  +++ +   k+i ++  + ++ +
  EFC37464.1 120 EMKQLTSLDICLNQIGDEGAKSISELEQLTLLYISANQIGDEgAKSISELKQLTSLAI 177
                 9****************99999*************99997776999999887766666 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.36
       NKWYS  37 FDnElkknlgiDvfnkdfdkd 57 
                 F  E+k+++++D+ n+ +  +
  EFC37464.1 213 FISEMKQLTSLDIGNNRIGAE 233
                 5679*********99988654 PP

>> NOC3p  Nucleolar complex-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.14   3.2e+02       9      37 ..      10      43 ..       5      81 .. 0.72
   2 ?    1.9   0.1      0.14   3.2e+02       9      29 ..     154     174 ..     103     178 .. 0.61
   3 ?    4.6   0.1     0.019        44      10      41 ..     155     191 ..     147     200 .. 0.65
   4 ?    7.2   0.2     0.003       6.7       5      41 ..     174     215 ..     170     245 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.14
       NOC3p  9 lassiledPeenlsllkrllklaeskds.....a 37
                 ++++  +  +++s++k+l++l  s+++     a
  EFC37464.1 10 YCNQVGVEGAKSISEMKQLTSLNISNNEigdkgA 43
                6888888889999999999998777665455551 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.14
       NOC3p   9 lassiledPeenlsllkrllk 29 
                  a++i ++  +++s+lk+l++
  EFC37464.1 154 SANQIGDEGAKSISELKQLTS 174
                 234444444444444444444 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.019
       NOC3p  10 assiledPeenlsllkrllklaeskds.....avtvr 41 
                 a++i ++  +++s+lk+l++la s ++     a +++
  EFC37464.1 155 ANQIGDEGAKSISELKQLTSLAISANQigvkgAESIS 191
                 6788888888899999999877777643444433333 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.003
       NOC3p   5 eiaslassiledPeenlsllkrllklaeskds.....avtvr 41 
                 ++a  a++i  +  e++s+lk+l++la+s ++        ++
  EFC37464.1 174 SLAISANQIGVKGAESISELKQLTSLAASANQigaegVKFIS 215
                 678899999999*************99998865555522233 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (252 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       349  (0.0194657); expected 358.6 (0.02)
Passed bias filter:                      231  (0.0128842); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 1550.19
//
Query:       EFC37465.1  [L=475]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-42  142.8  27.0    1.1e-09   37.9   0.1   10.6 12  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.1    0.0018        33      15      44 ..      96     125 ..      77     128 .. 0.75
   2 !   11.7   1.1   9.1e-06      0.16       8      45 ..     145     182 ..     134     182 .. 0.74
   3 !   22.9   0.3     3e-09   5.3e-05       1      43 [.     163     201 ..     163     201 .. 0.98
   4 !   37.9   0.1   5.9e-14   1.1e-09       1      48 [.     184     231 ..     184     232 .. 0.97
   5 !   19.3   0.0   3.8e-08   0.00069       4      33 ..     252     281 ..     250     282 .. 0.93
   6 !    9.1   0.0   5.9e-05       1.1      18      45 ..     288     315 ..     283     320 .. 0.86
   7 !   13.4   0.0   2.6e-06     0.047       2      49 .]     297     345 ..     296     345 .. 0.94
   8 !   21.8   0.0   6.6e-09   0.00012       2      49 .]     323     370 ..     322     370 .. 0.87
   9 !   30.5   0.3   1.2e-11   2.2e-07       1      49 []     347     396 ..     347     396 .. 0.93
  10 !   29.9   0.3   1.8e-11   3.2e-07       1      49 []     372     421 ..     372     421 .. 0.84
  11 !   23.0   0.5   2.7e-09   4.8e-05       1      32 [.     398     429 ..     398     435 .. 0.96
  12 !    8.4   0.0    0.0001       1.8      18      46 ..     438     467 ..     429     471 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0018
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsya 44 
                  +  l+e +k+ + ++ +A++ n   ++++
  EFC37465.1  96 LFSSLDETWKCKISFIERAIQENYQTFRFL 125
                 444578999**************9999886 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 9.1e-06
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 +v+ n+++++yl +    D+e+++kA+k+n + l++++
  EFC37465.1 145 LVELNPEIIRYLIKIDGFDIELLKKACKKNISLLRFIP 182
                 46667777777655544499999999999999999987 PP

  == domain 3  score: 22.9 bits;  conditional E-value: 3e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 D E+ ++a+kkn s l++++    +D+++ +  ++ n+ al+y
  EFC37465.1 163 DIELLKKACKKNISLLRFIP----CDRDFHISVIEHNPQALKY 201
                 89******************....*****************98 PP

  == domain 4  score: 37.9 bits;  conditional E-value: 5.9e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 Dr++   ++++n+ alky  + ++nD eivl+A+ +++t l yas+++
  EFC37465.1 184 DRDFHISVIEHNPQALKYSKDLFRNDEEIVLRAITKDKTTLQYASDSI 231
                 99*******************************************986 PP

  == domain 5  score: 19.3 bits;  conditional E-value: 3.8e-08
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkA 33 
                 +vl  vk+ +s +kyl+++ k D e+vlk 
  EFC37465.1 252 LVLSGVKTKPSLFKYLPDSVKIDQEFVLKL 281
                 89999***********************97 PP

  == domain 6  score: 9.1 bits;  conditional E-value: 5.9e-05
     DUF4116  18 ylseeLknDkeivlkAvkqngtalsyas 45 
                 +++ +Lk+ +e+ ++ vk + +a++ + 
  EFC37465.1 288 FIPQSLKQSREFRMEWVKYDAKAFETCK 315
                 89******************99998766 PP

  == domain 7  score: 13.4 bits;  conditional E-value: 2.6e-06
     DUF4116   2 rEivleavkkngsalkyl.seeLknDkeivlkAvkqngtalsyaseeLr 49 
                 rE+ +e vk + +a++ + + eL++ ++++l  +  + + l+ a++ L+
  EFC37465.1 297 REFRMEWVKYDAKAFETCkDLELRSERQFLLNSLTTYRHTLRDAPPILK 345
                 9*****************5577***********************9986 PP

  == domain 8  score: 21.8 bits;  conditional E-value: 6.6e-09
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 r++ l+ ++++   l+ +++ Lk Dke+vl+++k  ++ ls  se Lr
  EFC37465.1 323 RQFLLNSLTTYRHTLRDAPPILKDDKEFVLECLKFPSNRLSETSERLR 370
                 7899999999999*********************66666777777766 PP

  == domain 9  score: 30.5 bits;  conditional E-value: 1.2e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsyaseeLr 49 
                 D+E+vle++k  ++ l   se+L+ D ++v  A+ q + ++++yas+ Lr
  EFC37465.1 347 DKEFVLECLKFPSNRLSETSERLRDDEQVVSCALMQQSsINFEYASDRLR 396
                 9********************************77555389******998 PP

  == domain 10  score: 29.9 bits;  conditional E-value: 1.8e-11
     DUF4116   1 DrEivleavkkngs.alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+++v  a+ + +s +++y+s++L+ Dke+v+k ++  +  +s++se L+
  EFC37465.1 372 DEQVVSCALMQQSSiNFEYASDRLRDDKEFVMKNIELFPGMFSHISERLK 421
                 566666675555444********************************986 PP

  == domain 11  score: 23.0 bits;  conditional E-value: 2.7e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 D+E+v++ ++ ++  + ++se+Lk+Dkei+ k
  EFC37465.1 398 DKEFVMKNIELFPGMFSHISERLKKDKEIIVK 429
                 9****************************965 PP

  == domain 12  score: 8.4 bits;  conditional E-value: 0.0001
     DUF4116  18 ylseeLknDkeivlkAvkqng.talsyase 46 
                  l +e+  D  +vl +v++n+  +ls++++
  EFC37465.1 438 SLENEFMEDEGFVLDIVEKNPqLVLSFIPP 467
                 455788889999999999999779999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       638  (0.0355848); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 2942.90
//
Query:       EFC37466.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       786  (0.0438396); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.25s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 2356.48
//
Query:       EFC37467.1  [L=409]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      8e-35  120.6   0.0      4e-34  118.3   0.0    2.0  1  CoA_transf_3  CoA-transferase family III


Domain annotation for each model (and alignments):
>> CoA_transf_3  CoA-transferase family III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.3   0.0   2.2e-38     4e-34      50     368 .]      40     402 ..      29     402 .. 0.81

  Alignments for each domain:
  == domain 1  score: 118.3 bits;  conditional E-value: 2.2e-38
  CoA_transf_3  50 kgesayflavnrnKrsvalDlkseegrellkrLv..............akADVvieNfrpgvlerl.glgy.eelrainPrLiyasvsgyGqs.Gpk 129
                    +++++++++nr+K+ ++l++k+++  e lkrL+              +   V+i++ rpg+le+l g+g+ eel + n +Li++++s++Gq+ G++
    EFC37467.1  40 SSSGLIYHCFNRGKQAISLNFKKKQHVEELKRLIccysndnddgdqrrKAVKVLIDSSRPGKLESLlGVGKiEELLEENLQLIICRISAFGQDiGKY 136
                   467899***************************9777776666555545567***********9954887559*******************889** PP

  CoA_transf_3 130 akrpgyDlvaqaasGlmsltge...pdgpPvkvgvplgDivtgllaavailaal.............larer..tGkGqvidvslleaalallapql 208
                   ++ p++D++a  ++G+++++g+   ++++     ++l D++tg+  a+ ++a++              +rer   G  +vid+s++++a++ +++ l
    EFC37467.1 137 SDIPAHDMNAVGSAGVFDVAGDvseKNKQLKPLPIQLSDVLTGYSSALQVVAMVrkiealnysvkstEERERilRGMNRVIDISMFDNAISAIQMPL 233
                   *******************98855344445667899****************986666666555544345556778999****************99 PP

  CoA_transf_3 209 leylatgevperqgnrdp..aaapygvyrtkdgwvaiaaatdkqwaalckalgrpe....laedprfatnasrlenraeldaelaewlaertaaewl 299
                     +l++ ++ + +g++    ++  y++y+tk g +a+++ ++++w  +++al  ++     ++ ++f t +    n  +l++++ ++l++++a+ew+
    EFC37467.1 234 SLTLNGFDKMASEGRSVLsgSILGYNIYPTKSGQLAVGCLEPHFWSGFIQALSVHDkenpKDSWKQFTTVEFLFSNDSKLKQRIVKVLEQKSAEEWE 330
                   999888888887788888767777**************************999888554433345666666667888******************** PP

  CoA_transf_3 300 ellaaa.gvpaapvntleevlddpqlaarglvvevddpdygevpvvglpvrlsetpa...rvkraa.PklGedt 368
                   +++a   ++p+++v++l+ev d + l++r+++++ +  + + + + ++ +++s+ ++   ++ ++  P lGe++
    EFC37467.1 331 KIFAFDlKLPITKVRKLKEV-DRELLQQRNMLTSSNLVK-NALDYKSIQLTVSGNQSeelQPMNEFgPLLGEHN 402
                   ***9655*************.999********9988777.4455555555554444421234444469999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       912  (0.0508673); expected 358.6 (0.02)
Passed bias filter:                      543  (0.0302861); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 2578.01
//
Query:       EFC37468.1  [L=340]
Description: hypothetical protein NAEGRDRAFT_74842 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       811  (0.045234); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.24s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2270.83
//
Query:       EFC37469.1  [L=300]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.023   15.2   2.4      0.053   14.0   2.4    1.6  1  YxiJ      YxiJ-like protein
       0.17   11.8   3.6        0.5   10.3   3.6    1.8  1  zf-FCS    MYM-type Zinc finger with FCS sequence motif
       0.87   10.0   4.0        3.7    8.0   4.0    2.1  1  DUF3510   Domain of unknown function (DUF3510)


Domain annotation for each model (and alignments):
>> YxiJ  YxiJ-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   2.4   8.8e-06     0.053      22      97 ..     157     233 ..     137     244 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 8.8e-06
        YxiJ  22 kleedlkkdftkddclsaDfneyfmliagtLsyvln..gkeqkipkkqikllkksFfelyPqykflekelekypllsr 97 
                  ++ + +++ +k  c+  D+ +y   + ++L  +++  + +++i k    + ++ F +++ +   le ++++ +++ +
  EFC37469.1 157 TITLKWNNEKKKF-CFDTDISYYQQPTRASLFTMMQyhHVKNQIQKPCTAIYRQLFSTWFNKSSKLESTVKEIKTMLK 233
                 4555566565566.*****************999863366799999999999*****************999987654 PP

>> zf-FCS  MYM-type Zinc finger with FCS sequence motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   3.6   8.4e-05       0.5       7      33 ..     143     170 ..     143     170 .. 0.98

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 8.4e-05
      zf-FCS   7 wfCkkyikgkpef.tyvlendgvvgqFC 33 
                 ++Ck  +k+ +++ t+ l +++  ++FC
  EFC37469.1 143 SYCKSPCKYQHTVyTITLKWNNEKKKFC 170
                 69************************** PP

>> DUF3510  Domain of unknown function (DUF3510)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   4.0   0.00062       3.7      28     105 ..     144     245 ..     134     291 .. 0.59

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00062
     DUF3510  28 vptepSkyvseilkplktf................kkesekklseev..................leewlaevleevtsrYletisevlssvkkteesL 92 
                   ++p+ky++++   + +                 +          +                  +++ +++++++++s ++++ s++ s+vk+    L
  EFC37469.1 144 YCKSPCKYQHTVYTITLKWnnekkkfcfdtdisyyQ----------QptraslftmmqyhhvknqIQKPCTAIYRQLFSTWFNKSSKLESTVKEIKTML 232
                 555555555555555555423333333333333321..........02222223332222222225777788888888888888888888888888888 PP

     DUF3510  93 krlkkarkgaaas 105
                 kr   a +++ +s
  EFC37469.1 233 KREEMAMNSNENS 245
                 8877766666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1073  (0.0598472); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1920.07
//
Query:       EFC37470.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      9e-58  187.5  11.1    2.3e-07   30.3   0.1   11.2 11  LRR_6      Leucine Rich repeat
    1.7e-32  110.9  19.6      2e-05   24.9   0.1    7.1  9  LRR_4      Leucine Rich repeats (2 copies)
    2.1e-31  107.5  27.0    8.5e-09   35.1   0.3    6.1  7  LRR_8      Leucine rich repeat
    5.1e-19   65.9   4.1        3.3    8.6   0.0   11.8 12  LRR_1      Leucine Rich Repeat
    2.3e-09   37.0   1.3     0.0014   18.1   0.2    4.1  5  LRR_9      Leucine-rich repeat
    5.1e-05   23.2   0.5        1.6    8.6   0.0    5.1  5  DUF4347    Domain of unknown function (DUF4347)
     0.0024   17.9   2.4         51    4.0   0.0    6.9  8  DUF5490    Family of unknown function (DUF5490)
     0.0053   16.7  17.6        4.9    7.2   0.1    8.5 10  ApoB100_C  Apolipoprotein B100 C terminal
  ------ inclusion threshold ------
      0.059   14.1   0.1         87    4.0   0.0    4.7  5  LRR_2      Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.0   8.7e-08   0.00017       5      23 ..     129     147 ..     126     148 .. 0.91
   2 !   13.2   0.0   3.5e-05     0.071       5      22 ..     153     170 ..     150     171 .. 0.90
   3 !   30.3   0.1   1.2e-10   2.3e-07       3      24 .]     175     196 ..     173     196 .. 0.94
   4 !   19.4   0.1   3.7e-07   0.00074       5      24 .]     201     220 ..     198     220 .. 0.93
   5 !   13.2   0.0   3.6e-05     0.072       3      23 ..     223     243 ..     221     244 .. 0.89
   6 !   14.0   0.0     2e-05     0.041       5      22 ..     249     266 ..     246     267 .. 0.90
   7 !   19.6   0.0   3.2e-07   0.00063       5      24 .]     273     292 ..     270     292 .. 0.92
   8 !   21.9   0.0   5.8e-08   0.00012       5      24 .]     297     316 ..     294     316 .. 0.92
   9 ?    4.9   0.0     0.016        32       5      23 ..     321     339 ..     319     340 .. 0.87
  10 !   18.4   0.0   7.7e-07    0.0015       5      23 ..     345     363 ..     342     364 .. 0.91
  11 !    6.1   0.0    0.0066        13       5      15 ..     369     379 ..     366     383 .] 0.86

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 8.7e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++Ld+s N IgDeGa+ +
  EFC37470.1 129 LKSLDISENRIGDEGAKFI 147
                 9***************977 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+ +N Ig +G++ 
  EFC37470.1 153 LTSLDIGYNRIGVVGVKF 170
                 9**************985 PP

  == domain 3  score: 30.3 bits;  conditional E-value: 1.2e-10
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  hLt+Ld+sgN+IgDeG+++++
  EFC37470.1 175 KHLTSLDISGNGIGDEGVKSIS 196
                 6******************996 PP

  == domain 4  score: 19.4 bits;  conditional E-value: 3.7e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld + N IgD+Ga++++
  EFC37470.1 201 LTSLDFNNNRIGDKGAKSIS 220
                 9****************996 PP

  == domain 5  score: 13.2 bits;  conditional E-value: 3.6e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  hLt L+++ N+Ig eGa  +
  EFC37470.1 223 KHLTLLSINNNHIGAEGARFI 243
                 69***************9766 PP

  == domain 6  score: 14.0 bits;  conditional E-value: 2e-05
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 L++L++  N+IgDeGa+ 
  EFC37470.1 249 LKSLSIYNNQIGDEGAKF 266
                 9***************85 PP

  == domain 7  score: 19.6 bits;  conditional E-value: 3.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+sgN+Ig eG++ ++
  EFC37470.1 273 LTSLDISGNEIGVEGVIPIS 292
                 9***************9985 PP

  == domain 8  score: 21.9 bits;  conditional E-value: 5.8e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ gN+IgDeGa+ ++
  EFC37470.1 297 LTSLEIGGNQIGDEGAKLIS 316
                 9****************985 PP

  == domain 9  score: 4.9 bits;  conditional E-value: 0.016
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L +L++  N+Ig eGa+ +
  EFC37470.1 321 LISLNIYNNQIGIEGAKFI 339
                 6689999*********977 PP

  == domain 10  score: 18.4 bits;  conditional E-value: 7.7e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++L + gN+IgDeG++ +
  EFC37470.1 345 LKSLYIGGNQIGDEGVKFI 363
                 9***************977 PP

  == domain 11  score: 6.1 bits;  conditional E-value: 0.0066
       LRR_6   5 LteLdLsgNdI 15 
                 Lt+Ld+ +N+I
  EFC37470.1 369 LTSLDIGYNEI 379
                 9********96 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.7         9   1.8e+04      27      34 ..      16      23 ..      15      26 .. 0.52
   2 !   11.4   0.0   0.00017      0.35      13      38 ..     115     141 ..     105     144 .. 0.74
   3 !   23.9   0.0     2e-08   3.9e-05       1      37 [.     151     188 ..     151     200 .. 0.84
   4 !   20.4   1.4   2.6e-07   0.00051       1      36 [.     199     235 ..     199     240 .. 0.83
   5 !   24.9   0.1   9.8e-09     2e-05       1      38 [.     247     282 ..     247     293 .. 0.88
   6 !   19.2   0.0   5.8e-07    0.0012       1      38 [.     271     309 ..     271     312 .. 0.83
   7 !   19.2   0.1     6e-07    0.0012       1      36 [.     295     331 ..     295     337 .. 0.88
   8 !   22.2   0.2   6.9e-08   0.00014       1      38 [.     319     357 ..     319     358 .. 0.84
   9 !   19.6   0.0   4.6e-07   0.00092       1      35 [.     343     378 ..     343     382 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 9
                EEE-.-S- CS
       LRR_4 27 eLdLsgNn 34
                eL + +Nn
  EFC37470.1 16 ELFMINNN 23
                67773443 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00017
                 --E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4  13 ltdipl..leklpnLkeLdLsgNnlitd 38 
                 l +i+   +  +++Lk+Ld+s+N +i+d
  EFC37470.1 115 LDSIQVkfITEMKQLKSLDISEN-RIGD 141
                 66777773335*********999.7765 PP

  == domain 3  score: 23.9 bits;  conditional E-value: 2e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 ++L++Ld++ N++  ++  + + +++L++Ld+sgN  i+
  EFC37470.1 151 KQLTSLDIGYNRIGVVGVkFINeMKHLTSLDISGN-GIG 188
                 58************9999*6655***********9.664 PP

  == domain 4  score: 20.4 bits;  conditional E-value: 2.6e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++Ld++nN++ d +   ++ +++L+ L++ +Nn i
  EFC37470.1 199 KQLTSLDFNNNRIGDKGAksISEMKHLTLLSI-NNNHI 235
                 58************977775445*********.77777 PP

  == domain 5  score: 24.9 bits;  conditional E-value: 9.8e-09
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L++ nNq+ d +  + + +++L++Ld+sgN     
  EFC37470.1 247 KQLKSLSIYNNQIGDEGAkFINeMKQLTSLDISGN----E 282
                 58*************999*6666************....4 PP

  == domain 6  score: 19.2 bits;  conditional E-value: 5.8e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++Ld+s+N +   +  + + +++L++L + gN +i+d
  EFC37470.1 271 KQLTSLDISGNEIGVEGViPISeMKQLTSLEIGGN-QIGD 309
                 58***********9666675555*********777.9876 PP

  == domain 7  score: 19.2 bits;  conditional E-value: 6e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L +++Nq+ d +  l + +++L +L++  Nn+i
  EFC37470.1 295 KQLTSLEIGGNQIGDEGAkLISeMKQLISLNI-YNNQI 331
                 58*************99996655*********.88899 PP

  == domain 8  score: 22.2 bits;  conditional E-value: 6.9e-08
                 SS--EEE--SS---E-S-..HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L++ nNq+  i++  + + +++Lk+L++ gN +i+d
  EFC37470.1 319 KQLISLNIYNNQIG-IEGakFISeMKQLKSLYIGGN-QIGD 357
                 589***********.777685555*********777.8876 PP

  == domain 9  score: 19.6 bits;  conditional E-value: 4.6e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnl 35 
                 ++L++L++++Nq+ d +  + + +++L++Ld+  N  
  EFC37470.1 343 KQLKSLYIGGNQIGDEGVkFISeMKQLTSLDIGYN-E 378
                 58*************99996655*********666.4 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.6   3.1e+03       9      21 ..      46      58 ..      44      63 .. 0.78
   2 !   24.6   0.1     8e-09   1.6e-05       9      61 .]     111     163 ..     104     163 .. 0.89
   3 !   35.1   0.3   4.3e-12   8.5e-09       2      61 .]     152     211 ..     151     211 .. 0.98
   4 !   31.4   3.3   5.8e-11   1.2e-07       2      61 .]     176     235 ..     175     235 .. 0.98
   5 !   25.6   1.8   3.7e-09   7.4e-06       2      61 .]     224     283 ..     223     283 .. 0.98
   6 !   25.2   0.0   5.1e-09     1e-05       2      61 .]     296     355 ..     295     355 .. 0.98
   7 !   15.6   0.0     5e-06    0.0099       2      37 ..     344     379 ..     343     381 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.6
                TTS--SEE-TTSS CS
       LRR_8  9 snNrltslddeaF 21
                ++  ++ +dd++F
  EFC37470.1 46 CFEIISMIDDSWF 58
                5667999*****9 PP

  == domain 2  score: 24.6 bits;  conditional E-value: 8e-09
                 TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   9 snNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 s+  l s++ ++ + +++Lk+Ld+s+N++    ++ +s +++L+sLd+ +Nr+
  EFC37470.1 111 SRRLLDSIQVKFITEMKQLKSLDISENRIGDEGAKFISEMKQLTSLDIGYNRI 163
                 445599*********************************************97 PP

  == domain 3  score: 35.1 bits;  conditional E-value: 4.3e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+  Nr+ +++ ++ + +++L++Ld+s N +     +++s L++L+sLd ++Nr+
  EFC37470.1 152 QLTSLDIGYNRIGVVGVKFINEMKHLTSLDISGNGIGDEGVKSISELKQLTSLDFNNNRI 211
                 7*********************************************************97 PP

  == domain 4  score: 31.4 bits;  conditional E-value: 5.8e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+s N + + + ++ + l++L++Ld +nN++    ++++s +++L+ L +++N++
  EFC37470.1 176 HLTSLDISGNGIGDEGVKSISELKQLTSLDFNNNRIGDKGAKSISEMKHLTLLSINNNHI 235
                 8*********************************************************98 PP

  == domain 5  score: 25.6 bits;  conditional E-value: 3.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L+++nN++ + +  + + +++Lk+L++ nN++    ++ +  +++L+sLd+sgN +
  EFC37470.1 224 HLTLLSINNNHIGAEGARFISEMKQLKSLSIYNNQIGDEGAKFINEMKQLTSLDISGNEI 283
                 89********************************************************87 PP

  == domain 6  score: 25.2 bits;  conditional E-value: 5.1e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL +  N++ + + +  + +++L +L++ nN++    ++ +s +++L+sL++ gN++
  EFC37470.1 296 QLTSLEIGGNQIGDEGAKLISEMKQLISLNIYNNQIGIEGAKFISEMKQLKSLYIGGNQI 355
                 7*********************************************************98 PP

  == domain 7  score: 15.6 bits;  conditional E-value: 5e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37 
                 +L+sL++  N++ + + ++ + +++L++Ld+++N++
  EFC37470.1 344 QLKSLYIGGNQIGDEGVKFISEMKQLTSLDIGYNEI 379
                 79********************************98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       2.1   4.1e+03       7      15 ..      60      68 ..      54      73 .. 0.80
   2 ?    5.8   0.0     0.014        28       1      18 [.     128     145 ..     128     150 .. 0.80
   3 ?    4.0   0.0     0.053   1.1e+02       1      13 [.     152     164 ..     152     173 .. 0.82
   4 !    8.6   0.0    0.0016       3.3       1      23 []     176     198 ..     176     198 .. 0.88
   5 !    7.5   0.0    0.0038       7.5       1      21 [.     200     220 ..     200     222 .. 0.90
   6 ?    2.2   0.0      0.22   4.4e+02       1      16 [.     224     239 ..     224     246 .. 0.74
   7 ?    3.6   0.0     0.074   1.5e+02       1      16 [.     248     263 ..     248     269 .. 0.81
   8 ?    5.8   0.0     0.014        28       1      12 [.     272     283 ..     272     293 .. 0.79
   9 ?    3.2   0.0     0.098     2e+02       1      18 [.     296     313 ..     296     318 .. 0.79
  10 ?    2.7   0.0      0.14   2.8e+02       2      12 ..     321     331 ..     320     340 .. 0.81
  11 ?    5.9   0.0     0.013        25       1      17 [.     344     360 ..     344     366 .. 0.79
  12 ?    2.4   0.0      0.18   3.6e+02       1      12 [.     368     379 ..     368     382 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 2.1
       LRR_1  7 Lsnnpllgl 15
                L+n++l+++
  EFC37470.1 60 LNNCSLISK 68
                799999755 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld+s n++++ ++ 
  EFC37470.1 128 QLKSLDISENRIGDEGAK 145
                 59*********9877665 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.053
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+++n+++
  EFC37470.1 152 QLTSLDIGYNRIG 164
                 599*******984 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.0016
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++Ld+s+n +++ +  s++ L
  EFC37470.1 176 HLTSLDISGNGIGDEGVKSISEL 198
                 69**********99999998765 PP

  == domain 5  score: 7.5 bits;  conditional E-value: 0.0038
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld +nn+++++++ s++
  EFC37470.1 200 QLTSLDFNNNRIGDKGAKSIS 220
                 599************999987 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.22
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L+ L ++nn+++  +
  EFC37470.1 224 HLTLLSINNNHIGAEG 239
                 5899******995444 PP

  == domain 7  score: 3.6 bits;  conditional E-value: 0.074
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L + nn++++ +
  EFC37470.1 248 QLKSLSIYNNQIGDEG 263
                 59********997655 PP

  == domain 8  score: 5.8 bits;  conditional E-value: 0.014
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+s+n +
  EFC37470.1 272 QLTSLDISGNEI 283
                 599*******98 PP

  == domain 9  score: 3.2 bits;  conditional E-value: 0.098
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L +++n++++ ++ 
  EFC37470.1 296 QLTSLEIGGNQIGDEGAK 313
                 599********9776655 PP

  == domain 10  score: 2.7 bits;  conditional E-value: 0.14
       LRR_1   2 LrhLdLsnnpl 12 
                 L +L++ nn++
  EFC37470.1 321 LISLNIYNNQI 331
                 899******98 PP

  == domain 11  score: 5.9 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++++n++++ + 
  EFC37470.1 344 QLKSLYIGGNQIGDEGV 360
                 59*********977655 PP

  == domain 12  score: 2.4 bits;  conditional E-value: 0.18
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+++n +
  EFC37470.1 368 QLTSLDIGYNEI 379
                 599******975 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0011       2.1      61     124 ..     124     186 ..      65     190 .. 0.75
   2 !   12.3   0.0   4.5e-05     0.089      41     123 ..     126     209 ..      94     216 .. 0.59
   3 !   18.1   0.2   7.2e-07    0.0014      48     145 ..     181     276 ..     178     278 .. 0.77
   4 !   11.4   0.0   8.1e-05      0.16      63     125 ..     246     307 ..     241     312 .. 0.90
   5 !    9.1   0.0   0.00043      0.86      42     127 ..     271     357 ..     262     383 .] 0.49

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0011
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                   +k+lk+l +++nri   + ++   + +l++l +  n++  ++ ++ + ++k+l++l +  n 
  EFC37470.1 124 TEMKQLKSLDISENRIGDEGAKFISEMKQLTSLDIGYNRIGVVG-VKFINEMKHLTSLDISGNG 186
                 45788888888888888888888888888888888888887554.5788888888887776665 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 4.5e-05
       LRR_9  41 ldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                 + q+ ++d+s+n i +     +  +k+l +l +  nri  ++ ++ + + +l++l +++n + + + ++ + +lk+l++l + +n
  EFC37470.1 126 MKQLKSLDISENRIGDegAKFISEMKQLTSLDIGYNRIGVVGVKFINEMKHLTSLDISGNGIGDEG-VKSISELKQLTSLDFNNN 209
                 445566666666664411222344555556666666666666666666666666666666666544.355666666665555444 PP

  == domain 3  score: 18.1 bits;  conditional E-value: 7.2e-07
       LRR_9  48 dlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrl 144
                 d+s n i +  + ++  lk+l +l +nnnri   + +    + +l+ l ++nn++   +    + ++k+l++ls+ +n + ++       i+ +kql+ 
  EFC37470.1 181 DISGNGIGDegVKSISELKQLTSLDFNNNRIGDKGAKSISEMKHLTLLSINNNHIGAEGA-RFISEMKQLKSLSIYNNQIGDEG---AKFINEMKQLTS 275
                 6666666432267778899999*********9888888888899999999****998887.8999**********999987653...345555666555 PP

       LRR_9 145 l 145
                 l
  EFC37470.1 276 L 276
                 5 PP

  == domain 4  score: 11.4 bits;  conditional E-value: 8.1e-05
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 +k+lk+l++ nn+i   + ++ + + +l++l +++ne+     + P+ ++k+l++l +  n +
  EFC37470.1 246 MKQLKSLSIYNNQIGDEGAKFINEMKQLTSLDISGNEIGV-EGVIPISEMKQLTSLEIGGNQI 307
                 899***********************************85.5678**********99877765 PP

  == domain 5  score: 9.1 bits;  conditional E-value: 0.00043
       LRR_9  42 dqfdtidlsdndirkldgfPl..lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                  q+ ++d+s n+i     +P   +k+l +l +  n+i   + +l   + +l +l + nn++   +  + + ++k+l++l +  n + +
  EFC37470.1 271 KQLTSLDISGNEIGVEGVIPIseMKQLTSLEIGGNQIGDEGAKLISEMKQLISLNIYNNQIGIEGA-KFISEMKQLKSLYIGGNQIGD 357
                 455555666666544333443335566666666666655555555555555555555555543333.555555555555554444432 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.059   1.2e+02     103     121 ..     140     158 ..     135     165 .. 0.92
   2 ?    0.1   0.0      0.32   6.4e+02     105     122 ..     166     183 ..     162     190 .. 0.87
   3 ?   -1.1   0.0      0.77   1.5e+03     103     122 ..     188     207 ..     185     217 .. 0.82
   4 !    8.6   0.0   0.00078       1.6      81     123 ..     240     280 ..     199     286 .. 0.79
   5 ?    4.1   0.0     0.019        39      97     121 ..     352     374 ..     295     377 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.059
     DUF4347 103 geaGeafvekLaqltgadv 121
                 g++G +f+++++qlt  d+
  EFC37470.1 140 GDEGAKFISEMKQLTSLDI 158
                 789************9998 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.32
     DUF4347 105 aGeafvekLaqltgadva 122
                  G +f++++++lt  d++
  EFC37470.1 166 VGVKFINEMKHLTSLDIS 183
                 699***********9996 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.77
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G + +++L+qlt  d+ 
  EFC37470.1 188 GDEGVKSISELKQLTSLDFN 207
                 7899999********98875 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.00078
     DUF4347  81 aqwgealsedadillYgCnvAageaGeafvekLaqltgadvaA 123
                 a++ +++++ + + +Y  +++ +  G +f+++++qlt  d++ 
  EFC37470.1 240 ARFISEMKQLKSLSIYNNQIGDE--GAKFINEMKQLTSLDISG 280
                 45567788889999999999876..***************975 PP

  == domain 5  score: 4.1 bits;  conditional E-value: 0.019
     DUF4347  97 gCnvAageaGeafvekLaqltgadv 121
                 g ++  g++G +f+++++qlt  d+
  EFC37470.1 352 GNQI--GDEGVKFISEMKQLTSLDI 374
                 4444..5679999999999999887 PP

>> DUF5490  Family of unknown function (DUF5490)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0         4     8e+03       6      23 ..     109     127 ..     102     128 .. 0.72
   2 ?    4.0   0.0     0.026        51       9      24 ..     137     152 ..     132     157 .. 0.89
   3 ?    0.3   0.0      0.37   7.4e+02      10      24 ..     162     176 ..     160     192 .. 0.71
   4 ?    0.3   0.0      0.35     7e+02       9      24 ..     209     224 ..     206     235 .. 0.88
   5 ?   -1.4   0.0       1.2   2.5e+03      10      23 ..     234     247 ..     227     251 .. 0.76
   6 ?    2.8   0.0     0.061   1.2e+02       8      24 ..     256     272 ..     249     277 .. 0.85
   7 ?   -0.3   0.0      0.56   1.1e+03      10      23 ..     330     343 ..     322     346 .. 0.84
   8 ?   -1.2   0.0         1   2.1e+03      10      24 ..     354     368 ..     352     373 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4
     DUF5490   6 klsqriaee.rakffqnmk 23 
                 k+s+r+ +  + kf  +mk
  EFC37470.1 109 KFSRRLLDSiQVKFITEMK 127
                 6777776543689999998 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.026
     DUF5490   9 qriaeerakffqnmkh 24 
                 +ri +e akf  +mk 
  EFC37470.1 137 NRIGDEGAKFISEMKQ 152
                 69************96 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.37
     DUF5490  10 riaeerakffqnmkh 24 
                 ri     kf ++mkh
  EFC37470.1 162 RIGVVGVKFINEMKH 176
                 566666899999999 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.35
     DUF5490   9 qriaeerakffqnmkh 24 
                 +ri ++ ak   +mkh
  EFC37470.1 209 NRIGDKGAKSISEMKH 224
                 6999999********9 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 1.2
     DUF5490  10 riaeerakffqnmk 23 
                  i  e a+f  +mk
  EFC37470.1 234 HIGAEGARFISEMK 247
                 57778888888887 PP

  == domain 6  score: 2.8 bits;  conditional E-value: 0.061
     DUF5490   8 sqriaeerakffqnmkh 24 
                  ++i +e akf ++mk 
  EFC37470.1 256 NNQIGDEGAKFINEMKQ 272
                 57899**********96 PP

  == domain 7  score: -0.3 bits;  conditional E-value: 0.56
     DUF5490  10 riaeerakffqnmk 23 
                 +i  e akf  +mk
  EFC37470.1 330 QIGIEGAKFISEMK 343
                 678899****9999 PP

  == domain 8  score: -1.2 bits;  conditional E-value: 1
     DUF5490  10 riaeerakffqnmkh 24 
                 +i +e  kf  +mk 
  EFC37470.1 354 QIGDEGVKFISEMKQ 368
                 689999*******96 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1         2   4.1e+03       7      19 ..       6      17 ..       2      22 .. 0.74
   2 ?    3.1   0.1     0.046        92       9      32 ..     110     134 ..     107     139 .. 0.80
   3 ?    2.1   0.1     0.095   1.9e+02      12      32 ..     138     158 ..     132     163 .. 0.81
   4 ?   -0.3   0.0      0.56   1.1e+03      19      32 ..     169     182 ..     166     184 .. 0.88
   5 ?    0.7   0.0      0.27   5.4e+02      15      36 ..     213     234 ..     205     235 .. 0.81
   6 ?    1.1   0.0      0.19   3.8e+02      19      34 ..     241     256 ..     233     259 .. 0.88
   7 ?    3.3   0.1     0.039        79      10      32 ..     256     278 ..     248     280 .. 0.85
   8 !    7.2   0.1    0.0025       4.9      11      34 ..     305     328 ..     298     331 .. 0.87
   9 ?   -0.4   0.0      0.58   1.2e+03      19      32 ..     337     350 ..     329     352 .. 0.85
  10 ?    2.0   0.0       0.1     2e+02      12      32 ..     354     374 ..     351     379 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2
   ApoB100_C  7 qefsdqlsdyyEk 19
                q+f +ql+ + E 
  EFC37470.1  6 QDFEKQLI-SEEL 17
                89999998.5555 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.046
   ApoB100_C   9 fsdqlsdy.yEkliaeskrLiDLsI 32 
                 fs +l+d+ + k+i+e k+L  L I
  EFC37470.1 110 FSRRLLDSiQVKFITEMKQLKSLDI 134
                 77888888456********987776 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.095
   ApoB100_C  12 qlsdyyEkliaeskrLiDLsI 32 
                 ++ d   k+i+e k+L  L I
  EFC37470.1 138 RIGDEGAKFISEMKQLTSLDI 158
                 5666677*********98877 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.56
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k L  L I
  EFC37470.1 169 KFINEMKHLTSLDI 182
                 9********98877 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.27
   ApoB100_C  15 dyyEkliaeskrLiDLsIekYh 36 
                 d   k i+e k L  LsI++ h
  EFC37470.1 213 DKGAKSISEMKHLTLLSINNNH 234
                 555688************9977 PP

  == domain 6  score: 1.1 bits;  conditional E-value: 0.19
   ApoB100_C  19 kliaeskrLiDLsIek 34 
                 ++i+e k+L  LsI +
  EFC37470.1 241 RFISEMKQLKSLSIYN 256
                 8*********999965 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.039
   ApoB100_C  10 sdqlsdyyEkliaeskrLiDLsI 32 
                  +q+ d   k+i+e k+L  L I
  EFC37470.1 256 NNQIGDEGAKFINEMKQLTSLDI 278
                 578999999*********98877 PP

  == domain 8  score: 7.2 bits;  conditional E-value: 0.0025
   ApoB100_C  11 dqlsdyyEkliaeskrLiDLsIek 34 
                 +q+ d   kli+e k+Li L I +
  EFC37470.1 305 NQIGDEGAKLISEMKQLISLNIYN 328
                 57788888************9965 PP

  == domain 9  score: -0.4 bits;  conditional E-value: 0.58
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  L I
  EFC37470.1 337 KFISEMKQLKSLYI 350
                 9******9977766 PP

  == domain 10  score: 2.0 bits;  conditional E-value: 0.1
   ApoB100_C  12 qlsdyyEkliaeskrLiDLsI 32 
                 q+ d   k+i+e k+L  L I
  EFC37470.1 354 QIGDEGVKFISEMKQLTSLDI 374
                 6667777*********98877 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       4.1   8.1e+03      11      19 ..      40      48 ..      33      50 .. 0.84
   2 ?   -1.1   0.1       1.9   3.8e+03       7      18 ..      53      65 ..      53      67 .. 0.84
   3 ?    4.0   0.0     0.044        87       2      23 ..     129     148 ..     129     148 .. 0.86
   4 ?    2.0   0.0      0.19   3.7e+02       2      15 ..     249     262 ..     249     267 .. 0.85
   5 ?    0.8   0.0      0.45   9.1e+02       2      23 ..     345     364 ..     345     364 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 4.1
       LRR_2 11 rfsdedsle 19
                +fsd+ ++e
  EFC37470.1 40 IFSDDVCFE 48
                589999998 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.9
       LRR_2  7 LdsVrf.sdedsl 18
                +d+ +f  + +sl
  EFC37470.1 53 IDDSWFiLNNCSL 65
                5888999999997 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.044
       LRR_2   2 LKtLhLdsVrfsdedslekLLS 23 
                 LK+L ++ +r+ de    k++S
  EFC37470.1 129 LKSLDISENRIGDE--GAKFIS 148
                 9**********999..666666 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.19
       LRR_2   2 LKtLhLdsVrfsde 15 
                 LK+L+++++ + de
  EFC37470.1 249 LKSLSIYNNQIGDE 262
                 9*******999777 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.45
       LRR_2   2 LKtLhLdsVrfsdedslekLLS 23 
                 LK+L++  + + de   +k++S
  EFC37470.1 345 LKSLYIGGNQIGDE--GVKFIS 364
                 9*****99999888..777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       582  (0.0324614); expected 358.6 (0.02)
Passed bias filter:                      235  (0.0131073); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2306.15
//
Query:       EFC37471.1  [L=188]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0056   16.8   0.2      0.011   15.9   0.0    1.6  2  SAM_2     SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
      0.017   15.6   0.1      0.026   15.0   0.1    1.3  1  SAM_1     SAM domain (Sterile alpha motif)


Domain annotation for each model (and alignments):
>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   1.2e-06     0.011       2      63 ..      31      92 ..      30      95 .. 0.83
   2 ?   -3.9   0.0       1.8   1.6e+04      46      55 ..     100     109 ..      98     111 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.2e-06
                GGHHHHHHHHHHHHTTT..GGGHHHHHHTTCSHHHHHTTSCHHHHHHTTHHHHHHHHHHHHHHH CS
       SAM_2  2 eswsledvaeWLrsigl..kqytdnFrdagitgaelllrlteedLkrlGitsvghrkkilkkiq 63
                ++w++++  +WL + g+    ++d   ++ ++g   +l+++ ed  ++Gi +    + +++ i+
  EFC37471.1 31 KNWTVDNFRQWLIESGYdkSSVVDVIIKHRFDG-GSILNIKIEDWLEIGIPKGAC-LSLISRID 92
                79***************999*************.5555************77543.55555555 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 1.8
                 HTTHHHHHHH CS
       SAM_2  46 rlGitsvghr 55 
                 +lGi +++ +
  EFC37471.1 100 QLGILQLCNQ 109
                 7888887766 PP

>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.1   2.9e-06     0.026       2      64 .]      32      95 ..      31      95 .. 0.95

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 2.9e-06
                CTTHSSHHHHHHHTTS..GGGHHHHHTTTSSHHHHTTSCHHHHHHCTTTSHHHHHHHHHHHHHHH CS
       SAM_1  2 kwsvedVgeWLesigl..gqYadlFrageidgdaLlllteddLeklgvtllGHrkkIlyaIqrLk 64
                +w+v+  ++WL + g+  +  +d   +++ dg  +l+++ +d +++g+ + G  +++ ++I+ Lk
  EFC37471.1 32 NWTVDNFRQWLIESGYdkSSVVDVIIKHRFDGGSILNIKIEDWLEIGIPK-GACLSLISRIDELK 95
                7999*********9999899****************************99.**********9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (188 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       461  (0.0257125); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 1277.58
//
Query:       EFC37472.1  [L=311]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.1e-14   52.3   0.0      7e-12   45.9   0.0    2.6  1  Methyltransf_25  Methyltransferase domain
    7.4e-13   48.6   0.7    2.3e-12   47.0   0.3    1.9  2  Methyltransf_31  Methyltransferase domain
      2e-12   47.7   0.0    2.9e-10   40.8   0.0    3.4  2  Methyltransf_12  Methyltransferase domain
    2.1e-12   47.2   0.1    4.1e-12   46.3   0.1    1.4  1  Methyltransf_23  Methyltransferase domain
    4.3e-12   46.5   0.0    3.3e-10   40.5   0.0    2.7  2  Methyltransf_11  Methyltransferase domain
    5.3e-10   38.9   2.2    6.9e-10   38.6   2.2    1.1  1  Pox_MCEL         mRNA capping enzyme
    5.8e-09   35.6   1.2    4.6e-05   22.9   0.4    2.7  3  Ubie_methyltran  ubiE/COQ5 methyltransferase family
    7.7e-06   26.0   0.1    1.5e-05   25.0   0.1    1.4  1  Methyltransf_32  Methyltransferase domain
    2.3e-05   24.0   0.1    3.7e-05   23.3   0.1    1.3  1  CheR             CheR methyltransferase, SAM binding domain
     0.0015   18.4   0.0     0.0026   17.5   0.0    1.5  1  PCMT             Protein-L-isoaspartate(D-aspartate) O-methyl
  ------ inclusion threshold ------
      0.013   15.2   0.0      0.026   14.2   0.0    1.5  1  TPMT             Thiopurine S-methyltransferase (TPMT)
      0.015   15.1   1.9      0.031   14.1   0.5    2.3  2  DUF919           Nucleopolyhedrovirus protein of unknown func
      0.022   14.0   0.1       0.22   10.8   0.1    2.0  1  Methyltransf_34  Putative SAM-dependent methyltransferase
      0.058   12.6   0.0      0.099   11.8   0.0    1.4  1  NNMT_PNMT_TEMT   NNMT/PNMT/TEMT family


Domain annotation for each model (and alignments):
>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.9   0.0   5.5e-15     7e-12       1      97 []      61     185 ..      61     185 .. 0.79

  Alignments for each domain:
  == domain 1  score: 45.9 bits;  conditional E-value: 5.5e-15
                      EEEET-TTSHHHHHHHCTS..TSSEEEEEESSHHHHHHHHHHHHH......TTTTEEEEESBC......CGBS.............SSTTTEEE CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrl..gkakvtgvDiseemleaareraee......eglnvefvqgda......edlp.............fedgsfDl 67 
                      vL lGcG+G++t  l +++  + ++v+gvD+s +m++ a++  e+      +++ +ef++gd+      e+l+             +e+  fD+
       EFC37472.1  61 VLNLGCGSGNDTWVLYNQFesHIKSVIGVDLSNDMIQLANNSKEQvenslsKKIPLEFIVGDViklnenEQLKklyykhsnknetkQESPVFDF 154
                      89*****************7559****************977766654443444*********5555443333555555555544347779*** PP

                      EEEESTGGG.SSHHHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  68 vvssgalhh.lsdedlekalkeiarvLkpgG 97 
                      v++++ lh+  + e+l k++k i+ +LkpgG
       EFC37472.1 155 VTACHLLHYsSDYEELCKMCKSISGMLKPGG 185
                      ***877**966778999*************9 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.0   0.3   1.8e-15   2.3e-12       3     128 ..      57     207 ..      55     247 .. 0.78
   2 ?   -1.2   0.0       1.3   1.6e+03      49      78 ..     267     299 ..     257     308 .. 0.64

  Alignments for each domain:
  == domain 1  score: 47.0 bits;  conditional E-value: 1.8e-15
  Methyltransf_31   3 kglrvlDlGCGtGeltfelaeelgpkae.vvGiDiseeaielAre...naqklgld..nveFeqgdieelekl..led...............e 73 
                      ++l vl lGCG+G++t +l+ +  ++++ v+G+D s ++i+lA++     ++  ++   +eF +gd+ +l+++  l++                
       EFC37472.1  57 EKLMVLNLGCGSGNDTWVLYNQFESHIKsVIGVDLSNDMIQLANNskeQVENSLSKkiPLEFIVGDVIKLNENeqLKKlyykhsnknetkqesP 150
                      56789***************988888889***************955423333333668**********7766244449999999999998888 PP

  Methyltransf_31  74 kfDlilsnevl...naladpdkileeiervlkpggilliedprllaelp..akveeeska 128
                       fD++++  +l    +  +++k  ++i+  lkpgg +l+ + +    ++  a++ +++k+
       EFC37472.1 151 VFDFVTACHLLhysSDYEELCKMCKSISGMLKPGGTFLTLNSN---PFLnqAQINQDQKK 207
                      8999999788877777788999999*************99999...33344555555553 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.3
  Methyltransf_31  49 qklgldnveFeqgdiee..lekl.ledekfDli 78 
                      +  g++ v F++    e  l  + + ++++D+ 
       EFC37472.1 267 KLAGFSKVVFHKLRLDEkeLGAKeYGRNSIDVC 299
                      456899999998555542255556777888884 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.8   0.0   2.3e-13   2.9e-10       1      99 []      62     187 ..      62     187 .. 0.84
   2 ?    0.7   0.0      0.69   8.9e+02      29      72 ..     258     301 ..     256     309 .. 0.80

  Alignments for each domain:
  == domain 1  score: 40.8 bits;  conditional E-value: 2.3e-13
  Methyltransf_12   1 LeiGcGtGsllrallekl..pdieytgvDispsai..edakeklakrennnnnnvelealdlldldgg....................ssfDlv 70 
                      L +GcG+G+ + +l +++  + ++++gvD+s ++i  ++ +++  +++  +   +e+ + d+++l ++                      fD v
       EFC37472.1  62 LNLGCGSGNDTWVLYNQFesHIKSVIGVDLSNDMIqlANNSKEQVENSLSKKIPLEFIVGDVIKLNENeqlkklyykhsnknetkqesPVFDFV 155
                      679****************6666777*********66444444455555555667888888888888888999*************9999**** PP

  Methyltransf_12  71 vasnvlhhl...kdirevldnirklLkpgGrl 99 
                      +a+++lh+    +++ ++ ++i  +LkpgG +
       EFC37472.1 156 TACHLLHYSsdyEELCKMCKSISGMLKPGGTF 187
                      *********87778888888**********75 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.69
  Methyltransf_12  29 spsaiedakeklakrennnnnnvelealdlldldgg.ssfDlvva 72 
                      sp++   ++ kla  ++  +++++l++++l+ ++ g +s D+ +a
       EFC37472.1 258 SPQSY-EKALKLAGFSKVVFHKLRLDEKELGAKEYGrNSIDVCTA 301
                      67777.788899999999999999999998877766899998766 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.3   0.1   3.2e-15   4.1e-12      19     163 ..      54     274 ..      33     275 .. 0.69

  Alignments for each domain:
  == domain 1  score: 46.3 bits;  conditional E-value: 3.2e-15
  Methyltransf_23  19 klraggrvLdiGcGtGillevlrengf....svtgvDlspeaveiae................................kakkaqkdqfdeqea 76 
                      ++ ++  vL +GcG+G+ + vl  ++     sv+gvDls  ++++a                                 k+  +++++   +e 
       EFC37472.1  54 RNSEKLMVLNLGCGSGNDTWVLYNQFEshikSVIGVDLSNDMIQLANnskeqvenslskkiplefivgdviklneneqlKKLYYKHSNK--NET 145
                      2444459*********877777555423366**************98877777777777777777777777776666543333333333..456 PP

  Methyltransf_23  77 aepqgkfdlIvlrevlehvpdppellrqiat...llkpgGylllseplasl.......................kedrllld............ 132
                      ++++  fd++++ ++l+   d++el ++ ++   +lkpgG +l + ++  l                       k      +            
       EFC37472.1 146 KQESPVFDFVTACHLLHYSSDYEELCKMCKSisgMLKPGGTFLTLNSNPFLnqaqinqdqkklgvyrsnfmidsK------Ernylidgdqfei 233
                      66677****************9977666555555********999988776665665555555555555555442......0555555666776 PP

  Methyltransf_23 133 ......wlylvpag..rhi..sffsarslkelleeaGlevv 163
                            ++++ +++   +i  ++fs +s++++l+ aG++ v
       EFC37472.1 234 sidlnfNEFDQNENfiVKIqnRYFSPQSYEKALKLAGFSKV 274
                      6666666777777766344569****************976 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.5   0.0   2.6e-13   3.3e-10       1      95 [.      62     188 ..      62     189 .. 0.84
   2 ?   -3.0   0.0       9.5   1.2e+04      56      66 ..     290     300 ..     260     303 .. 0.62

  Alignments for each domain:
  == domain 1  score: 40.5 bits;  conditional E-value: 2.6e-13
                      EEET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHHHHCCHHT-........EEEE...................TTEECCCTSS-TT-EE CS
  Methyltransf_11   1 LdvGcGtGrlaealakrg....arvvgvDlskemlklakekaseegl........kvef...................vvadaeklpfednsfD 63 
                      L++GcG+G  +  l +++    ++v+gvDls+ m++la++ +++ ++        +  f                    +++  +++ e+  fD
       EFC37472.1  62 LNLGCGSGNDTWVLYNQFeshiKSVIGVDLSNDMIQLANNSKEQVENslskkiplE--FivgdviklneneqlkklyyKHSNKNETKQESPVFD 153
                      789************7777889****************999999888888877440..366666666666666666668888888999999*** PP

                      EEEEES-CCC-...CCHHHHHHHHHHHEEEEEEEE CS
  Methyltransf_11  64 lvvssevlhhv...edpekalkeiaRvLkpgGllv 95 
                      +v++ + lh+    e++ k +k i  +LkpgG+++
       EFC37472.1 154 FVTACHLLHYSsdyEELCKMCKSISGMLKPGGTFL 188
                      ***********8888999999999********986 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 9.5
                      SS-TT-EEEEE CS
  Methyltransf_11  56 pfednsfDlvv 66 
                       +  ns+D+++
       EFC37472.1 290 EYGRNSIDVCT 300
                      45667777766 PP

>> Pox_MCEL  mRNA capping enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.6   2.2   5.4e-13   6.9e-10      58     251 ..      51     252 ..      36     286 .. 0.79

  Alignments for each domain:
  == domain 1  score: 38.6 bits;  conditional E-value: 5.4e-13
    Pox_MCEL  58 tkldesnklkvLdldcgkGgD...LeKyekgeIsklvatDiaeesieeckeRYnklrsekkskyykFdaelirsdsfvssvrevfed............ 141
                 +++++s+kl vL+l+cg G D   L   +  +I++ +++D +++ i+ +++     ++ ++s   k   e+i +d ++ + +e +++            
  EFC37472.1  51 ETNRNSEKLMVLNLGCGSGNDtwvLYNQFESHIKSVIGVDLSNDMIQLANNSK---EQVENSLSKKIPLEFIVGDVIKLNENEQLKKlyykhsnknetk 146
                 44579****************888889999*******************9765...3444444457999*******99888888887888899999988 PP

    Pox_MCEL 142 .yelkfdivslQFaiHYsFeseekartvlrNvaellasGGkvlgTtpdgdelskltvkklkviekdlpsfgNsiyvvkfeeekiev....plfGakYey 235
                   +  fd v +   +HYs + ee    + + ++ +l++GG++l T+ +  +l      +  +i++d+++ g + +   +++++ ++      f +  + 
  EFC37472.1 147 qESPVFDFVTACHLLHYSSDYEELC-KMCKSISGMLKPGGTFL-TLNSNPFL------NQAQINQDQKKLGVYRSNFMIDSKERNYlidgDQFEISIDL 237
                 76778****************9999.9***************9.56666667......44555678888888888888888877775555555555555 PP

    Pox_MCEL 236 nledvvkdvpEyivkf 251
                 n ++   +   +ivk 
  EFC37472.1 238 NFNEFD-QNENFIVKI 252
                 555544.445566655 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.4   3.6e-08   4.6e-05      10     115 ..       8     131 ..       1     136 [. 0.70
   2 !   12.2   0.0   6.8e-05     0.087      94     154 ..     129     192 ..     126     227 .. 0.83
   3 ?   -1.8   0.0       1.2   1.6e+03     190     221 ..     248     279 ..     240     281 .. 0.77

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 3.6e-08
                      XXXXX-HHHHHHHHHH......HHHTTTHHHHHH.HHHHH--S--TT.....EEEEES-TT-HHHHHHHHHHHHHH.EEEEEES-HHHHHHH.. CS
  Ubie_methyltran  10 kevfesvaskyDlmnd......vlslgihrlWkk.fveklvavkrga.....kvlDvagGtgDlafklsdsvgekg.kvvvlDinenmLkvg.. 88 
                       ++++s+++kyD+         ++  ++ + W + f+ + + + + +      vl++ +G+g+ +  l ++ +++   v+++D++++m++ +  
       EFC37472.1   8 LQLYQSISNKYDKNRHhphrlyIVNPNMIHHWERiFTVEKERNETNRnseklMVLNLGCGSGNDTWVLYNQFESHIkSVIGVDLSNDMIQLAnn 101
                      568999999999865333333355556666687777765544333333456689*******************99846999********98721 PP

                      .HHHHHHHTSS..TEEEEE--TTT-TTS-T CS
  Ubie_methyltran  89 .ekklkeegki..nieflqanaeeLpfedd 115
                       +++++++  +   +ef++++  +L+++++
       EFC37472.1 102 sKEQVENSLSKkiPLEFIVGDVIKLNENEQ 131
                      1445555443344789*****999998876 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 6.8e-05
                      HHTSSTEEEEE--TTT-TTS-T-EEEEEEES-GGG-S-HH...HHHHHHHHHEEEEEEEEEEEE CS
  Ubie_methyltran  94 eegkinieflqanaeeLpfeddsfDvvtvsfGlrnvtDkl...kaLkeayrvlkpGGrlvvlef 154
                      +e  +++ + ++n +e + e   fD+vt  + l   +D++   k  k++  +lkpGG+++ l+ 
       EFC37472.1 129 NEQLKKLYYKHSNKNETKQESPVFDFVTACHLLHYSSDYEelcKMCKSISGMLKPGGTFLTLNS 192
                      55667888999***************************9844467789999********99974 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.2
                      HHHHHHHHS--HHHHHHHHHHTTEEEEEEEEE CS
  Ubie_methyltran 190 yLvesirafPdqetlkeliedaGfksveyesl 221
                      ++v+  +++   + +++ ++ aGf++v +++l
       EFC37472.1 248 FIVKIQNRYFSPQSYEKALKLAGFSKVVFHKL 279
                      55666666777778899999999999999986 PP

>> Methyltransf_32  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.1   1.2e-08   1.5e-05      16     124 ..      48     159 ..      37     162 .. 0.76

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 1.2e-08
  Methyltransf_32  16 llkelakesgaltvvDvGaGkgYLsfvlalkeke.yklkvvgidakeelvekaekraeklgkkfnkr..lsfaelsieeatssktltkkve.ae 105
                        +e++++s++l v+ +G+G g  + vl+  + e +  +v+g+d+++++++ a++ +e++++ ++k+  l+f+ +++ + +++++l+k    ++
       EFC37472.1  48 ERNETNRNSEKLMVLNLGCGSGNDTWVLYN-QFEsHIKSVIGVDLSNDMIQLANNSKEQVENSLSKKipLEFIVGDVIKLNENEQLKKLYYkHS 140
                      45566889999*******************.55548999**********************999887445788888877776665555444334 PP

  Methyltransf_32 106 eekeeqeekesvdvligLH 124
                      +++e+++e+   d++++ H
       EFC37472.1 141 NKNETKQESPVFDFVTACH 159
                      4444455555567788777 PP

>> CheR  CheR methyltransferase, SAM binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.1   2.9e-08   3.7e-05      22     172 ..      48     188 ..      36     209 .. 0.79

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 2.9e-08
                 HHHHHHHTSSSEEEEEES-TTTHHHHHHHHHHHCHSTTTSSS-EEEEEEESSCHHHHHHHHTEEECCHH.TTS-HHHHHHHEEEEETTCEEE-.HHHHT CS
        CheR  22 pllakaknekrvriwsagcssGeEpYslAmllketlpkaaklkvkilAtDidlkvlekAkagvykeeel.eglseelleryfekseddsykvk.keike 118
                 ++ + ++n++++ +++ gc+sG+ ++ l   +++     +k   +++++D+++ +++ A++     e++ ++ls+++  +++    +d  k + +e  +
  EFC37472.1  48 ERNETNRNSEKLMVLNLGCGSGNDTWVLYNQFES----HIK---SVIGVDLSNDMIQLANNSK---EQVeNSLSKKIPLEFI---VGDVIKLNeNEQLK 133
                 44556667799**************977666665....677...89************99864...3343679****99**9...66677754145567 PP

                 TEEEEE--TTT-SGGG--EEEEEE-SSGGGC-C.HHHHHHHHHHHCCEEEEEEEE CS
        CheR 119 lvkFeklnllekksvlgklDvifcrnvliYfde.etqekvlerfaeklkpgglLl 172
                    ++++n +e+k+ +  +D +++  +l Y +  e+  k+ + ++ +lkpgg  l
  EFC37472.1 134 KLYYKHSNKNETKQESPVFDFVTACHLLHYSSDyEELCKMCKSISGMLKPGGTFL 188
                 789**************************9765166789************9865 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   2.1e-06    0.0026      75     132 ..      59     122 ..      51     156 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 2.1e-06
                 -EEEEES-TTSHHHHHHHHHHCTTC.EEEEEESBH...HHHHHHHHHHHHCTTC..SEEEEES- CS
        PCMT  75 arvLevGsGsGyltavlarlvgekg.rvvsierik...elveeakrnlkkldle..nvivvvgD 132
                   vL++G+GsG  t vl++ ++++   v++++ ++   +l++++k++++++ ++   + ++vgD
  EFC37472.1  59 LMVLNLGCGSGNDTWVLYNQFESHIkSVIGVDLSNdmiQLANNSKEQVENSLSKkiPLEFIVGD 122
                 569******************99884699**987622256677888888887775556777777 PP

>> TPMT  Thiopurine S-methyltransferase (TPMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0     2e-05     0.026      31     113 ..      51     130 ..      15     138 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2e-05
                 HT.T-S--EEEEEET-TT-HHHHHH-BT....TEEEEEE-S-HHHHHHHHHHHTTSGGGGGEEEE--...........-TTT---SS CS
        TPMT  31 dalkakaglrvlvPlCGkaldlvwlAeq....grevvGvelselAvekffeeanlepkvkelsgvkeysageiellcgdvFtlraee 113
                 +++++ ++l vl  +CG++ d   l +q     ++v+Gv+ls+  ++ +   +n++++v++    k      +e + gdv  l+++e
  EFC37472.1  51 ETNRNSEKLMVLNLGCGSGNDTWVLYNQfeshIKSVIGVDLSNDMIQLA---NNSKEQVENSLSKKI----PLEFIVGDVIKLNENE 130
                 33445555668888*******99998873222468***********995...556666666666665....7888888888887765 PP

>> DUF919  Nucleopolyhedrovirus protein of unknown function (DUF919)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.5   2.5e-05     0.031      24      48 ..      36      60 ..      11      63 .. 0.79
   2 ?   -2.0   0.0       2.7   3.4e+03      40      54 ..     201     215 ..     197     219 .. 0.63

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.5e-05
      DUF919 24 sqHfErlkkitKnpkElqdlekkln 48
                 +H+Er+  ++K+ +E ++  +kl+
  EFC37472.1 36 IHHWERIFTVEKERNETNRNSEKLM 60
                58****************9999998 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.7
      DUF919  40 lqdlekklnklRqeF 54 
                 +++ +kkl   R +F
  EFC37472.1 201 INQDQKKLGVYRSNF 215
                 445566677777777 PP

>> Methyltransf_34  Putative SAM-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   0.00017      0.22     158     261 ..     103     218 ..      22     222 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00017
  Methyltransf_34 158 aaaanaplleeerlevsfkkedvLkl.seeelksll.........ekkpalvtllFtlnEL..ftesiskttkfLlrltaalkkgslLLvvdSp 239
                      +++++++l  ++++ ++f   dv+kl ++e+lk+l          + ++  v  + t   L  ++++ ++  k+ ++++ +lk+g ++L ++S 
       EFC37472.1 103 KEQVENSL--SKKIPLEFIVGDVIKLnENEQLKKLYykhsnknetK-QESPVFDFVTACHLlhYSSDYEELCKMCKSISGMLKPGGTFLTLNSN 193
                      22333333..588999**********55667777769999999852.444444444544442356669************************** PP

  Methyltransf_34 240 Gsysevavgkeekk...ypmkfLld 261
                          ++++++++kk   y  +f++d
       EFC37472.1 194 PFLNQAQINQDQKKlgvYRSNFMID 218
                      **********999944455566666 PP

>> NNMT_PNMT_TEMT  NNMT/PNMT/TEMT family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   7.7e-05     0.099     158     199 ..     151     191 ..     125     214 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 7.7e-05
                     .EEEEEEESSHHHH-SSHHHHHHHHHHHHTTEEEEEEEEEEE CS
  NNMT_PNMT_TEMT 158 kadvvvtifcleaacedleeylralrnlasllkpGGhlvlgg 199
                      +d v +   l ++ +d+ee ++  +++ ++lkpGG +++++
      EFC37472.1 151 VFDFVTACHLLHYS-SDYEELCKMCKSISGMLKPGGTFLTLN 191
                     37877777777775.69*********************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1085  (0.0605165); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 1932.26
//
Query:       EFC37473.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-35  121.2   1.1    6.6e-35  120.9   1.1    1.0  1  G-alpha   G-protein alpha subunit
      0.002   17.6   0.0     0.0038   16.7   0.0    1.5  1  Arf       ADP-ribosylation factor family


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  120.9   1.1   7.3e-39   6.6e-35     209     352 ..       1     161 [.       1     163 [. 0.90

  Alignments for each domain:
  == domain 1  score: 120.9 bits;  conditional E-value: 7.3e-39
                 E-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGGCCTT--..H.CCHH CS
     G-alpha 209 vgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgklskyfpsye..grkndl 305
                 +gG+r erkkW++ f+++d+i+F+vslsefd +++ed ++ r +es+++F +++ n+ +++ p++L++nK+D+le+Kl +++++++f ++   ++++++
  EFC37473.1   1 MGGSRHERKKWIHQFNSADVILFVVSLSEFDTNCFEDGETPRWKESFDIFMNLLYNPSFAKLPFVLLFNKKDVLEQKLVNQSFASHFDDFPsdKNGQNI 99 
                 69*************************************************************************************99986678899* PP

                 HHHHHHHHHHHHCCCCCCE...........SGGS....CEEEEEE-TT-HHHHHHHHHHHHH CS
     G-alpha 306 esvlkylrnkFeeihkeks...........nnrr....kiythftsatdtkevqkviesvrd 352
                 +++++++ +k+++  k ++           +n++    ++ + + +a+d++++ +v++++ +
  EFC37473.1 100 DDCIQFIVDKYSSSVKTRQlllnpgeccvdPNDEnagpSMLVRVLNAFDENNLLTVFKDITE 161
                 **************998888886666666522223444888889999999999999999976 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   4.3e-07    0.0038      65     130 ..       1      76 [.       1      88 [. 0.83

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 4.3e-07
                 E-SSGGGGGGGGGGCTTESEEEEEEETT-CT..........THHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTS CS
         Arf  65 vGGqeklRplWknYfektdavifvvDsadre..........RleeakeeLkalleeeelkevallvlaNKqDlpea 130
                 +GG ++ R+ W + f++ d+++fvv  ++ +          R +e+ + + +ll +   ++ ++++l NK+D+ e+
  EFC37473.1   1 MGGSRHERKKWIHQFNSADVILFVVSLSEFDtncfedgetpRWKESFDIFMNLLYNPSFAKLPFVLLFNKKDVLEQ 76 
                 69***********************7665433344455566999999999**********************8765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       453  (0.0252663); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1118.18
//
Query:       EFC37474.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.7e-16   58.2   0.3    1.2e-15   57.6   0.0    1.4  2  G-alpha         G-protein alpha subunit
  ------ inclusion threshold ------
       0.18   11.8   0.0       0.33   10.9   0.0    1.4  1  AsnC_trans_reg  Lrp/AsnC ligand binding domain
       0.18   12.0   0.4          4    7.7   0.0    2.4  2  Phage_DsbA      Transcriptional regulator DsbA


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1      0.66   3.9e+03     317     330 ..      43      54 ..      15      79 .. 0.53
   2 !   57.6   0.0     2e-19   1.2e-15       6     160 ..     160     323 .]     155     323 .] 0.84

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 0.66
                 HCCCCCCESGGSCE CS
     G-alpha 317 eeihkeksnnrrki 330
                 +++  ++s+n++++
  EFC37474.1  43 NNL--QNSTNNNSF 54 
                 222..111222122 PP

  == domain 2  score: 57.6 bits;  conditional E-value: 2e-19
                 XXXXXXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS--...............--HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT....... CS
     G-alpha   6 aidkslkaerkarkkkrevkllllGqseSGKsTilkqlkllykkg...............fseeelatwraviqlnivrsiktilealesleselsesf 89 
                 + ++++  +++++ +  ++++lllG++e GKs ++k +k l+++                ++e++l+ + +vi++n++++++ ++e  e l +++    
  EFC37474.1 160 RYSSQMSVKNHTQIEPDKLNILLLGAGEVGKSLLFKLMKYLCEGPaqrstslididvstfYNENDLKGFVQVIRENVLHNMRWVIEGSEDLAIDI---R 255
                 4555666677777777899********************8886556999**********666666688***********************9999...4 PP

                 HHHC-SS-SCCCS-HCHHHH..........HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCGCCTT--TTHH CS
     G-alpha  90 elqelkerldplkkveasliaklssateeeqeiefnpraevgedikaLwndpgiqelyerrnkiklednae 160
                   +elk+++ ++ +  ++ ++  +s    + +  +++  e++e +++Lwnd+giqe ++rrn++++ dnae
  EFC37474.1 256 GGEELKAKAFDFADKVSE-MDGVESLYTVSGNCKVSK--EFCEFFVKLWNDEGIQESFKRRNEFRVYDNAE 323
                 788888888888776666.455666666678888888..***************************99985 PP

>> AsnC_trans_reg  Lrp/AsnC ligand binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   5.5e-05      0.33       9      35 ..     258     286 ..     250     289 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 5.5e-05
                     G..TTHHHHHHHHHHTSTTEEEEEEESSS CS
  AsnC_trans_reg   9 h..peqleefeealaelpeVvecyrvtGd 35 
                     +  ++   +f++++ e++ V+++y+v+G 
      EFC37474.1 258 EelKAKAFDFADKVSEMDGVESLYTVSGN 286
                     455566779*******************6 PP

>> Phage_DsbA  Transcriptional regulator DsbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.0   0.00067         4       6      27 ..     108     128 ..     105     142 .. 0.78
   2 ?    2.0   0.1      0.04   2.4e+02      11      37 ..     244     268 ..     232     275 .. 0.73

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00067
  Phage_DsbA   6 dskLkidsereLikDiaiRake 27 
                 dskL+++s ++L kDi +   +
  EFC37474.1 108 DSKLRVSS-NDLTKDISNNNLN 128
                 89****87.8******997655 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.04
  Phage_DsbA  11 idsereLikDiaiRakeelevdgkdFn 37 
                 i++ ++L  D  iR  eel+ ++ dF 
  EFC37474.1 244 IEGSEDLAID--IRGGEELKAKAFDFA 268
                 8888898766..578999999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       911  (0.0508115); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 2038.52
//
Query:       EFC37475.1  [L=636]
Description: Hypothetical protein NAEGRDRAFT_53722 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (636 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1059  (0.0590663); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.25s 00:00:00.76 Elapsed: 00:00:00.41
# Mc/sec: 4678.87
//
Query:       EFC37476.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.6e-21   75.3   4.9    3.5e-09   36.5   0.1    4.1  4  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.3   0.0    0.0042        76       7      28 ..      45      66 ..      41      70 .. 0.87
   2 ?    1.3   0.0     0.018   3.3e+02      69      95 ..      87     113 ..      84     115 .. 0.88
   3 !   33.4   0.1   1.8e-12   3.2e-08       7      90 ..     138     219 ..     134     223 .. 0.81
   4 !   36.5   0.1     2e-13   3.5e-09       3      94 ..     231     319 ..     229     322 .] 0.94

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.0042
                HHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr  7 kellaGglagavatlvttPldv 28
                 ++++G+ a ++++++ tP+  
  EFC37476.1 45 LNFVIGSSASVLGKMISTPIQC 66
                689****************976 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.018
                 HHHHHHHHHHHHHHHHHHHHHHHHHCT CS
   Mito_carr  69 lpnllrvapasalkfvlyetlkrlllk 95 
                 +  l++ ap++al ++l + + +ll++
  EFC37476.1  87 GSILFKFAPSQALALSLKDGFSELLMN 113
                 6678999*****************987 PP

  == domain 3  score: 33.4 bits;  conditional E-value: 1.8e-12
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHH....HHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   7 kellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiy....keeGlrglyrGllpnllrvapasalkfvlyetlk 90 
                  ++ +G+lagav++++ +P++++  +     ++++      +++ +k  +    k++G+ +l+ G+++  + +++++a  f+++++lk
  EFC37476.1 138 VQFSSGALAGAVSHCILHPMEMAQLKYHHYLSNHQ------VMSQFKGPMdfalKTNGFFKLFNGFGMFSMHSIIYRAFLFGTFDSLK 219
                 6899******************9777666544444......44444443333339******************************998 PP

  == domain 4  score: 36.5 bits;  conditional E-value: 2e-13
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
   Mito_carr   3 lsvlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlll 94 
                 l++l+++l + +a +++t++  P+  ++  + t ++s+   +   ++++lk++y + G+rgl+ G++ + l   ++  + +v+y+ l+++l 
  EFC37476.1 231 LGILSKILLAQAATCISTFFSIPFLNARREMITLQQSNLPIT---TRSCLKSLYSNSGFRGLFNGFVSQSLLHRSSGTAILVCYDLLQQYLS 319
                 678999*******************************99988...9*****************************************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       381  (0.0212505); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 2090.66
//
Query:       EFC37477.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.1e-58  192.1  13.2    3.4e-11   42.7   0.0    9.4 10  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.2   0.0    0.0041        73      16      30 ..      71      85 ..      49      88 .. 0.61
   2 !   31.9   0.0   4.5e-12     8e-08       1      45 [.     105     149 ..     105     151 .. 0.95
   3 !   12.6   0.2   4.9e-06     0.087       1      36 [.     150     185 ..     150     198 .. 0.87
   4 !   22.4   0.0     4e-09   7.2e-05       3      40 ..     201     237 ..     199     238 .. 0.94
   5 !   35.0   0.1   4.9e-13   8.8e-09       3      44 ..     225     266 ..     223     270 .. 0.90
   6 !   28.3   0.0   6.1e-11   1.1e-06       1      41 [.     273     313 ..     273     316 .. 0.94
   7 !   42.7   0.0   1.9e-15   3.4e-11       3      47 ..     322     366 ..     320     368 .. 0.94
   8 !   40.5   0.0   9.3e-15   1.7e-10       2      49 .]     346     392 ..     346     392 .. 0.98
   9 !   27.0   0.1   1.5e-10   2.8e-06       1      45 [.     370     413 ..     370     417 .. 0.92
  10 !   11.6   0.1   9.8e-06      0.18       1      29 [.     394     422 ..     394     425 .. 0.98

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.0041
     DUF4116 16 lkylseeLknDkeiv 30
                   ls+ L++Dkei+
  EFC37477.1 71 SSCLSDGLRKDKEIA 85
                3347999******97 PP

  == domain 2  score: 31.9 bits;  conditional E-value: 4.5e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 Dr++vl++v++n  al+ ++ ++ nD+ei+ +Av++n+++l+ +s
  EFC37477.1 105 DRDVVLKVVRHNATALTCADGKFMNDFEILCAAVRNNSSILYAIS 149
                 9**************************************998776 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 4.9e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 + E+ +  +kk ++ +k+ls+e++ + +++l  vk 
  EFC37477.1 150 NIEFLKYWIKKRPLDYKKLSSEMQANPDLALMVVKE 185
                 689****************************99995 PP

  == domain 4  score: 22.4 bits;  conditional E-value: 4e-09
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 E+vlea+k+++ +l+y+  ++ +Dk + ++Avkq++++
  EFC37477.1 201 EMVLEALKIDPTNLQYAR-NFLKDKTVFIEAVKQSPSN 237
                 99****************.7888************987 PP

  == domain 5  score: 35.0 bits;  conditional E-value: 4.9e-13
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                  +  eavk+ +s++ y++++L+ Dk+++l+ +++n+++++ +
  EFC37477.1 225 TVFIEAVKQSPSNIVYADSSLRTDKDFILQLIEINPNVMRNI 266
                 56689********************************99876 PP

  == domain 6  score: 28.3 bits;  conditional E-value: 6.1e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 D +i+ ++v++ng+ l+y+s +++ ++eiv+ A+ qn++++
  EFC37477.1 273 DVDIARQVVQRNGLLLHYFSASIRENIEIVKMAIGQNPNSI 313
                 5599**********************************986 PP

  == domain 7  score: 42.7 bits;  conditional E-value: 1.9e-15
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 +iv+ av+++g +l+y+ +++k  +e+vl Av+qng+al+++ ++
  EFC37477.1 322 DIVMDAVQTDGTSLQYIYSKFKDQREVVLTAVRQNGIALKFVQNS 366
                 9****************************************9765 PP

  == domain 8  score: 40.5 bits;  conditional E-value: 9.3e-15
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 rE+vl av++ng alk++ +++k D+ei++kA++ ng+++ y+++++r
  EFC37477.1 346 REVVLTAVRQNGIALKFVQNSWKMDREIIIKALN-NGCPFMYVDPSWR 392
                 8*********************************.*********9987 PP

  == domain 9  score: 27.0 bits;  conditional E-value: 1.5e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 DrEi+ +a+ + g+ + y+++++++Dkei+l A+  ++ a++ ++
  EFC37477.1 370 DREIIIKALNN-GCPFMYVDPSWRRDKEIALVALSHDSRAFKLID 413
                 9*********8.888***********************9999876 PP

  == domain 10  score: 11.6 bits;  conditional E-value: 9.8e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDkei 29 
                 D+Ei+l a+++++ a+k ++ +++nD ei
  EFC37477.1 394 DKEIALVALSHDSRAFKLIDLSIRNDEEI 422
                 9**************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       578  (0.0322383); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 3304.22
//
Query:       EFC37478.1  [L=676]
Description: hypothetical protein NAEGRDRAFT_74859 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.5e-15   55.6   0.0    1.5e-14   54.4   0.0    1.7  1  CHASE4       CHASE4 domain
    3.2e-10   40.3   3.5    3.2e-10   40.3   3.5    2.2  2  RGS          Regulator of G protein signaling domain
     0.0024   17.9   0.0     0.0083   16.1   0.0    1.9  1  PAS_8        PAS domain
     0.0077   16.5   0.0      0.019   15.2   0.0    1.7  1  PAS_9        PAS domain
     0.0081   16.5   0.0      0.031   14.6   0.0    2.1  1  HAMP         HAMP domain
  ------ inclusion threshold ------
       0.56   10.0   4.1          3    7.7   0.6    2.3  2  SP_C-Propep  Surfactant protein C, N terminal propeptide
       0.68   10.4   4.8        2.2    8.8   0.0    2.4  2  DUF3433      Protein of unknown function (DUF3433)
        8.7    7.2  16.6        7.5    7.4   9.6    2.8  2  KIAA1430     KIAA1430 homologue


Domain annotation for each model (and alignments):
>> CHASE4  CHASE4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.4   0.0   6.5e-18   1.5e-14       1     137 []      56     217 ..      56     217 .. 0.83

  Alignments for each domain:
  == domain 1  score: 54.4 bits;  conditional E-value: 6.5e-18
      CHASE4   1 alqaeldqlerllkdwavWDdtyafvqdrdpd.......yiesnlgd.etletlgldlvlfldad..gklvydqengq..........ekllseaeee. 78 
                 a+++++++++++l ++++WD++y+++++ + d       + + n+++ e l+  ++ +++fl+ +  gk+ yd+e++                      
  EFC37478.1  56 AIMDDFKNQMDILLTYSNWDSSYYLMKTYSVDqmnkrlnVSYGNIDHvEELTGANFIGYYFLNGTvaGKVGYDFESRMavpmptemyqL--------Ps 146
                 7999************************999999*************9****************999*****99988776655444431........14 PP

      CHASE4  79 .........s.grsgll.kldggpalvaaapI.ltsegegpsrGtlvfgryldeallsrlseltlldlels 137
                          s    g++ + dg ++lv+aap+     g ++ +G+++++ry+++ ++s++s++++++++++
  EFC37478.1 147 flmeniqilStMNIGYWtLKDGTLFLVMAAPVqCSGCGFTDTPGIMMWARYIRSVYVSQVSNRAQVCITMY 217
                 555555455245556653667778********4444555****************************9985 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       2.8   6.3e+03      18      52 ..     516     553 ..     510     558 .. 0.62
   2 !   40.3   3.5   1.4e-13   3.2e-10       2     112 ..     564     674 ..     563     676 .] 0.96

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.8
                 HHHHTTCT.HHHH..HHHHHHHHHTSSHHHHHHHHHHH CS
         RGS  18 Flesefse.enls..Fwlaveefkkakeqeelkkkake 52 
                 F +se+se e l+  ++l ++++ ++k+ +e k++ ++
  EFC37478.1 516 FPNSEKSEcESLRdtYLLVCKDLSEEKKLKEKKQQNQQ 553
                 55666666655533378888888888666666655555 PP

  == domain 2  score: 40.3 bits;  conditional E-value: 1.4e-13
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqeevfel 100
                 +++++++ ++r+ F++ +e+e s en+ F++ ve++++  + +++++k +++++++++ps +++lni+ ++ ++ +  +e+     ++++++++ v ++
  EFC37478.1 564 FDKMFNNTQLRQEFKKQCEKERSVENFLFLETVEQYRRIPNAQDRVEKQQQVLKQFIDPSGDNHLNISGQVLQQSKVEIENGLGRYDALDKLETFVRDM 662
                 899******************************************************************************99999*********9999 PP

                 HHHHHHHHHHTS CS
         RGS 101 lekdsypkFlks 112
                   +d + ++++ 
  EFC37478.1 663 VINDTWFRYCQQ 674
                 999999999875 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   3.7e-06    0.0083       2      57 ..     422     477 ..     421     490 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 3.7e-06
       PAS_8   2 rlralfesspdgiavvdlgd.rivdvNqaalellGysadlkgellgqllpvlrplle 57 
                 + r l++s++d ++ vd+ + +++++N a+   + ys+ ++g+   ++l+++  + e
  EFC37478.1 422 KTRILLNSISDMVLAVDRKTaNVTMANTAFFNKTRYSQKDLGSIS-RYLKEFSQESE 477
                 56779************44467*************9955566555.77777776655 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   8.3e-06     0.019       6     104 .]     437     540 ..     431     540 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 8.3e-06
       PAS_9   6 idnpdgrilyaNeaalrllGyspee..vlgksitdlfvtdpeanerlraaleqgrkkerevevvlirkngetfwvlltaspv..kdddgelvg.....i 95 
                 +d +  +++ aN+a+ + + ys ++   + ++++++  +++e  +++++++++ r    + e++l++++ e+++v+++a  +   ++++  +      +
  EFC37478.1 437 VDRKTANVTMANTAFFNKTRYSQKDlgSISRYLKEFS-QESELLSKINQLVQSSR---DSWETHLTKPTSEKIPVKISAKLIqfPNSEKSECEslrdtY 531
                 466667999*************999666888899999.88888888888888887...*********************88866444333333366677 PP

       PAS_9  96 ivilrDite 104
                 +++++D++e
  EFC37478.1 532 LLVCKDLSE 540
                 888888876 PP

>> HAMP  HAMP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   1.4e-05     0.031       6      49 ..     347     393 ..     346     408 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.4e-05
                 THHHHHHHHHHHHHHTTT..BTSST.CCTTSSSHHHHHHHHHHHHHH CS
        HAMP   6 ilrPLrrLaraarriaaG..dldtr.lpvsgrDEiGeLarafNaMld 49 
                 ++ PL +L  + r+i ++  +l  + +pv+g  Ei +L + +N+Ml+
  EFC37478.1 347 VVTPLVNLGYHLRKIMKNteNLADStIPVKGITEISTLTQRINTMLR 393
                 57788888888888887555666667*******************86 PP

>> SP_C-Propep  Surfactant protein C, N terminal propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.6    0.0014         3      31      64 ..       4      36 ..       2      51 .. 0.79
   2 ?    3.1   0.2     0.036        80      30      76 ..     328     373 ..     321     391 .. 0.57

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0014
  SP_C-Propep 31 ccplnlkrllivvvvvvlvvvvvlgallmglhms 64
                 +c l++k + iv+ v+ lvv+ +  a+l+g+ +s
   EFC37478.1  4 VCSLRVKNV-IVLAVLFLVVMTLFMAVLLGVLLS 36
                 689999986.566677888888889999998776 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.036
  SP_C-Propep  30 pccplnlkrllivvvvvvlvvvvvlgallmglhmsqkhtemvlemsi 76 
                   c  + l  l+i v+  v+vv   l  l   l    k te + + +i
   EFC37478.1 328 TCLVVILSSLIIFVLNEVIVVTP-LVNLGYHLRKIMKNTENLADSTI 373
                  45555555555554444444333.33333344445577887766665 PP

>> DUF3433  Protein of unknown function (DUF3433)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   2.5      0.21   4.6e+02      61      89 ..       6      34 ..       3      36 .. 0.85
   2 ?    8.8   0.0     0.001       2.2       1      49 [.     321     371 ..     321     399 .. 0.68

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.21
     DUF3433 61 alrnrhwlvalvslvtllsellpvlasgl 89
                +lr +++ v++v ++++++ ++ vl++ l
  EFC37478.1  6 SLRVKNVIVLAVLFLVVMTLFMAVLLGVL 34
                5777899999999**********999876 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.001
     DUF3433   1 flvsflpalvavlisllwaaldaavrrlaPFaaLa.h.rgataersllldy 49 
                 f++s++ + ++v++s l+  +  +v +++P   L  h r+   +   l+d+
  EFC37478.1 321 FGWSYGFTCLVVILSSLIIFVLNEVIVVTPLVNLGyHlRKIMKNTENLADS 371
                 99****************************999954542222222233333 PP

>> KIAA1430  KIAA1430 homologue
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.6     0.068   1.5e+02       5      63 ..     430     494 ..     426     529 .. 0.62
   2 ?    7.4   9.6    0.0033       7.5      32      90 ..     539     615 ..     534     644 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.068
    KIAA1430   5 lknikssidnkapkkpsh......lskkkkklqleeerlkeiereNqiLleklseimrrkgk.kks 63 
                 + ++   +d k+   + +      + + ++k   + +r+ +   + ++Ll+k+++  + ++    +
  EFC37478.1 430 ISDMVLAVDRKTANVTMAntaffnKTRYSQKDLGSISRYLKEFSQESELLSKINQLVQSSRDsW-E 494
                 55666666666555333223334334445555566678888888***********999995431.2 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0033
    KIAA1430  32 leeerlkeiereNqiLleklseimrrkgk.kksassqsqksktasksl.................naenrkkelqkI 90 
                  ee++lke +++Nq+Lle ++ im+ ++  ++ + +q++k++ ++++                  na+ r +++q++
  EFC37478.1 539 SEEKKLKEKKQQNQQLLESIKLIMEFDKMfNNTQLRQEFKKQCEKERSvenflfletveqyrripNAQDRVEKQQQV 615
                 5789***********************76744444444444444444457788999998888888888888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (676 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2121  (0.1183); expected 358.6 (0.02)
Passed bias filter:                      757  (0.0422221); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.81u 0.32s 00:00:01.13 Elapsed: 00:00:00.53
# Mc/sec: 3863.56
//
Query:       EFC37479.1  [L=216]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.4e-35  119.4   5.6    2.1e-34  118.2   5.6    1.6  1  ORMDL     ORMDL family
  ------ inclusion threshold ------
      0.052   11.8   2.3       0.07   11.3   2.3    1.1  1  SSP160    Special lobe-specific silk protein SSP160
       0.12   12.3   0.8        1.1    9.2   0.0    2.7  3  DUF3377   Domain of unknown function (DUF3377)
       0.17   11.3   2.7        0.2   11.2   0.2    2.0  2  SieB      Super-infection exclusion protein B
       0.65    9.3   3.4        1.5    8.1   0.2    2.2  2  DUF4191   Domain of unknown function (DUF4191)


Domain annotation for each model (and alignments):
>> ORMDL  ORMDL family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.2   5.6     6e-38   2.1e-34      11     136 .]      84     210 ..      62     210 .. 0.94

  Alignments for each domain:
  == domain 1  score: 118.2 bits;  conditional E-value: 6e-38
       ORMDL  11 glwviyiviilllkllllalpgvseevawtltnlvhnlvtyillHwikGtPfeta.dqgeydeltlWEQidegeqytptrkfLtvvPivLfllsthytk 108
                   w i++ ++l  k + ++  +  + ++wt+ nl+h+l+t++l+Hw kG+P++++    + ++ltlWEQ+d+++q+tptrkf++vvP vL+ll+++++ 
  EFC37479.1  84 AYWAIHFALVLYGKAFGDLQDTTRKVYTWTILNLLHSLITFVLFHWKKGSPYDYSmGYNDHSRLTLWEQLDDQKQFTPTRKFMFVVPCVLLLLTSYFVG 182
                 47******************999999****************************656668899************************************ PP

       ORMDL 109 ydlelfvinlivllvvvipKlpfmhrvR 136
                  ++ l+++n+++++vvv++Klp +h+ R
  EFC37479.1 183 DNMLLLFVNVVATVVVVLAKLPSFHKRR 210
                 *************************998 PP

>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   2.3   1.9e-05      0.07     103     190 ..       9      98 ..       5     103 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.9e-05
      SSP160 103 gsasssssssatstssststtssssttssnsttttsnstsssnstssg..ltssasvvslidtiawvyqdssvgiaylmvsilalfygqs 190
                  s s++ssss     + ts t s s   s+ t + s+s  +  +t  g  ++++  v  +  t+awv     + +ay  +    ++yg++
  EFC37479.1   9 TSPSNNSSSSNLDVPAGTSPTHSPSLFKSQMTRSESQSFLTISATNEGeiVSTNFNVQPFGATVAWVVYGLVIALAYWAIHFALVLYGKA 98 
                 57899999999999999******99999999999999987777777773255666788999*******************9999999986 PP

>> DUF3377  Domain of unknown function (DUF3377)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.43   1.5e+03      12      49 ..      55      92 ..      50      96 .. 0.69
   2 ?    9.2   0.0   0.00031       1.1      15      41 ..     149     176 ..     140     182 .. 0.83
   3 ?   -2.2   1.2       1.1   4.1e+03      37      50 ..     187     200 ..     184     204 .. 0.52

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.43
     DUF3377 12 evdvvvkiddeesgtvnaiaVvvPlvLllciLvliyai 49
                e ++v +  ++++ + +++ Vv  lv +l   ++ +a+
  EFC37479.1 55 EGEIVSTNFNVQPFGATVAWVVYGLVIALAYWAIHFAL 92
                55666665666677788999998888887766666665 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00031
     DUF3377  15 vvvkiddeesgt.vnaiaVvvPlvLllc 41 
                 + +++dd+++ t +   + vvP+vLll+
  EFC37479.1 149 LWEQLDDQKQFTpTRKFMFVVPCVLLLL 176
                 56789999888888999********995 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 1.1
     DUF3377  37 vLllciLvliyail 50 
                 +L + ++++++++l
  EFC37479.1 187 LLFVNVVATVVVVL 200
                 44444444444443 PP

>> SieB  Super-infection exclusion protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.2   5.5e-05       0.2      32      67 ..      72     107 ..      59     123 .. 0.80
   2 ?    0.0   0.2      0.15   5.4e+02      35      55 ..     169     189 ..     157     197 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 5.5e-05
        SieB  32 glwiglvflisiayllaqvvskllaeikekikkkre 67 
                   w++++++i++ay+ ++++  l++++   ++  ++
  EFC37479.1  72 VAWVVYGLVIALAYWAIHFALVLYGKAFGDLQDTTR 107
                 57***********************99988884333 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.15
        SieB  35 iglvflisiayllaqvvskll 55 
                 +  v+l+ ++y++ +++  l+
  EFC37479.1 169 VPCVLLLLTSYFVGDNMLLLF 189
                 446899999999999887765 PP

>> DUF4191  Domain of unknown function (DUF4191)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.3     0.037   1.3e+02      46      81 ..      67     102 ..      34     128 .. 0.66
   2 ?    8.1   0.2   0.00042       1.5      21      72 ..     155     206 ..     150     213 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.037
     DUF4191  46 llgslilllilgillgllvalivltrraekaayaqi 81 
                  +g ++ +++ g++++l    i ++  +  +a+  +
  EFC37479.1  67 PFGATVAWVVYGLVIALAYWAIHFALVLYGKAFGDL 102
                 346678888888888888777777766666555555 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00042
     DUF4191  21 edkkllwlllaaflvvvvvfvvlglllgslilllilgillgllvalivltrr 72 
                 ++k+++++   +f+v++v++++  +++g+ +lll++ +++ ++v+l  l   
  EFC37479.1 155 DQKQFTPTRKFMFVVPCVLLLLTSYFVGDNMLLLFVNVVATVVVVLAKLPSF 206
                 46778999999***************99999999999999998888766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (216 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       788  (0.0439511); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1391.56
//
Query:       EFC37480.1  [L=817]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0055   16.3   0.3      0.011   15.4   0.3    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
     0.0091   16.2   0.0      0.022   14.9   0.0    1.6  1  CCG            Cysteine-rich domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.3   1.2e-06     0.011       7     165 ..     566     744 ..     563     753 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 1.2e-06
  Guanylate_cyc   7 devtilFadIvgftalssahs....pievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevavesk. 97 
                    +++til + ++g  +l + ++       +v++L +++  ++ l++  ++    +  d++ +  ++++++ +h +k+a+  L ++e+l++ ++ +  
     EFC37480.1 566 KKITILCCHLEGLSELLKMSDttigSDIIVRMLSDVFDHVNALCRTSGGHVGAFENDCITISYNASSNQDKHQEKAAQGCLFLIEKLNTTKQGKWp 661
                    689999999999999999888888677799*********************************************************999999845 PP

  Guanylate_cyc  98 .............eglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkag..kiqvseetyellkeeqfelter 165
                                   l+ r  i + +v++g iG ++++++ +++ + +    m  t+k     + ++e+ ++  k  +f+++ +
     EFC37480.1 662 svlgsshqtkeimSLLNFRFAILYNEVCCGNIGtNEMKNFAIISSARTNFEIMLETTKRLglSVVITERLQKAIK-GSFNTRLV 744
                    689999****999999*****************88999****998877666666666654114555777777777.66666555 PP

>> CCG  Cysteine-rich domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   2.5e-06     0.022      19      68 ..     668     717 ..     663     729 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.5e-06
         CCG  19 kalkkllealgveleelekesCCGagggrsgkeelaealakrnvetaeet 68 
                 + +k++++ l+  + +l +e CCG+ g++++k+    + a+ n+e + et
  EFC37480.1 668 HQTKEIMSLLNFRFAILYNEVCCGNIGTNEMKNFAIISSARTNFEIMLET 717
                 5799*****************************98888888888877775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (817 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1428  (0.0796475); expected 358.6 (0.02)
Passed bias filter:                      633  (0.0353059); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.52
# Mc/sec: 4756.44
//
Query:       EFC37481.1  [L=295]
Description: hypothetical protein NAEGRDRAFT_81930 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0028   17.3   5.4     0.0042   16.8   4.4    1.8  2  MIF4G     MIF4G domain
  ------ inclusion threshold ------
        1.4    9.3   7.8         12    6.2   0.2    3.1  3  SirA      Sporulation inhibitor of replication protein SirA


Domain annotation for each model (and alignments):
>> MIF4G  MIF4G domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   4.4   4.6e-07    0.0042      69     212 .]     112     241 ..      94     241 .. 0.86
   2 ?   -3.5   0.0      0.72   6.5e+03      63      82 ..     272     291 ..     269     291 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 4.6e-07
                 HHHHHHHHHHHHHHHHHHC..-S-HHHHHHHHHHHHHHHHHHHHHHHHHHTTSSEHHHHHHHHHHHHHGGCCCCSCCHSCHHHHHHHHHHHHHHHHHHH CS
       MIF4G  69 qnFrikllnklqeefekry..eleneleenedgnrrrrlglvrflgelfklkmltskilldclkellssltketaddppqdleeieilltllttigktl 165
                    ++kll+k+q  f++    ++ +    ++    r+r+++++f+  l  + +++ski   ++++l++               +    l+llt   ++ 
  EFC37481.1 112 IALKKKLLTKCQIGFKEELviDEGKDVKLQKFEYMRKRSNNIKFIAKLLSNDLISSKIGAIIIESLFKPPSP----------TN----LKLLTMFVPLY 196
                 566789999999999996699888999999999999*********************************999..........44....56666666677 PP

                 CCCHHHHHHHHHHHHHHHHHHHCCHCSSSSHHHHHHHHHHHHHHHTT CS
       MIF4G 166 ennekakkeldqffkriqkiledatrqelssrirfmlkdlielkknk 212
                 e  +   k++++++++i  i++  + +++  ++rf l++li+  ++k
  EFC37481.1 197 E--NMEEKLVNLLISKINLIVKADDSNQVTDELRFDLMNLIDHTNPK 241
                 7..77789**************999****************988876 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 0.72
                 HHHHSHHHHHHHHHHHHHHH CS
       MIF4G  63 lnsrfqqnFrikllnklqee 82 
                 l+++ +++F + ll+k +ee
  EFC37481.1 272 LYAHDDEEFEQELLEKALEE 291
                 66666778888888888876 PP

>> SirA  Sporulation inhibitor of replication protein SirA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   1.0    0.0025        22      13      82 ..      47     116 ..      45     153 .. 0.86
   2 ?   -0.6   0.0      0.16   1.5e+03      12      28 ..     192     208 ..     187     224 .. 0.76
   3 ?    6.2   0.2    0.0013        12      24      61 ..     229     266 ..     222     279 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0025
                 HHHCTT-CHHHHHHHHHHHCS---HHHHHHHHHHHHEE---HHHHHHHHHHHCT.TSEEEEETTEEEEE- CS
        SirA  13 aklYkgreskLfklfeeiykakeedkeilykqieqitkplpklklnkklkqklsekigykkeknihvinn 82 
                 a+ Y+   s Lfk f+++  +++ ++e +++ ++  +++   +++ + +k++l+e++g  +e+ i+ +++
  EFC37481.1  47 AQNYESMRSALFKNFNQFDGSERMQSEWVDMIYSHAVERGLYNTMGNLMKEQLKENVGNLNENVIIALKK 116
                 78899*********************************99999999999999999988776666666655 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.16
                 HHHHCTT-CHHHHHHHH CS
        SirA  12 faklYkgreskLfklfe 28 
                 f  lY++ e+kL +l+ 
  EFC37481.1 192 FVPLYENMEEKLVNLLI 208
                 67789999999998874 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0013
                 HHHHHHHHCS---HHHHHHHHHHHHEE---HHHHHHHH CS
        SirA  24 fklfeeiykakeedkeilykqieqitkplpklklnkkl 61 
                 f+l++ i +++ ++ + l++q+e++  +lp+++ln+++
  EFC37481.1 229 FDLMNLIDHTNPKKLNTLDRQLETLQLELPIISLNQQI 266
                 899999******************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       739  (0.0412181); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1830.80
//
Query:       EFC37482.1  [L=324]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
        4.3    7.2  16.0    9.3e+03   -3.5  16.0    2.8  1  Ephrin_rec_like  Putative ephrin-receptor like


Domain annotation for each model (and alignments):
>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5  16.0      0.52   9.3e+03      11      35 ..      23      47 ..      16      84 .. 0.57

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 0.52
  Ephrin_rec_like 11 CipCprgtYqneegqlsClaCPlgt 35
                     C+ Cp+g++  +   + C  C  gt
       EFC37482.1 23 CSVCPKGYFATQNIEQICHVCDYGT 47
                     5555555555555555555554333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (324 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       676  (0.0377043); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1980.91
//
Query:       EFC37483.1  [L=1318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-09   37.6  10.9    3.7e-09   36.6  10.9    1.5  1  Zn_clus         Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6  10.9   2.1e-13   3.7e-09       2      39 ..     863     899 ..     862     900 .. 0.94

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 2.1e-13
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 aC +Cr+ + KCd+k PaC++C+++++eCt y+ ++++
  EFC37483.1 863 ACVQCRSLHKKCDKKLPACTKCVSRGVECT-YRTPKRN 899
                 9*****************************.9988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2091  (0.116627); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.16u 0.34s 00:00:01.50 Elapsed: 00:00:00.58
# Mc/sec: 6832.53
//
Query:       EFC37484.1  [L=589]
Description: ANK domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.7e-05   23.6   0.3       0.12   13.0   0.1    2.9  3  Ank_2         Ankyrin repeats (3 copies)
    0.00017   22.0   0.2        1.6    9.4   0.0    3.6  3  Ank_4         Ankyrin repeats (many copies)
    0.00024   21.3   0.1          3    8.3   0.1    3.7  2  Ank_5         Ankyrin repeats (many copies)
     0.0052   16.6   0.1      0.016   15.0   0.1    1.9  1  F-box         F-box domain
  ------ inclusion threshold ------
      0.032   13.7   0.0        2.2    7.7   0.0    2.3  2  AP_endonuc_2  Xylose isomerase-like TIM barrel
       0.19   11.7   0.7       0.56   10.1   0.1    2.1  2  F-box-like    F-box-like


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.0    0.0027       8.1      12      49 ..     371     420 ..     362     446 .. 0.60
   2 !    6.6   0.1    0.0039        12      12      69 ..     431     493 ..     420     505 .. 0.64
   3 !   13.0   0.1     4e-05      0.12      12      76 ..     463     545 ..     452     552 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0027
       Ank_2  12 lvklLl....egadpn.k..ngktaLhyAakngnleivklLleh.....a 49 
                 lvk++     +g d + k  +g ++Lh A++++ ++++ ++ ++     +
  EFC37484.1 371 LVKFFQvyspFGLDTDlKdiQGFNILHMAISGDMRHVIDFIFDYftfynQ 420
                 45555334444444445236788888888887777777887775555442 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0039
       Ank_2  12 lvklLlegadpnk..ngktaLhyAakngnleivklLleh......adndgrtpLhyAarsghleiv 69 
                 ++++L     +n+  +g++  ++ + + ++ i+  ++eh      +d+dg t+ hy a++g++  +
  EFC37484.1 431 ILNHLF---AANNrlDGRNSTFIIVTKEKTSIITKMMEHlvhfnaQDRDGLTVAHYYAQFGQISKL 493
                 444554...223123577777766666666776666665555576669999999888888876555 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 4e-05
       Ank_2  12 lvklLlegadpnk.ngktaLhyAakngnleivklLle...h...............adndgrtpLhyAarsghleivklLlekg 76 
                 ++++L+ ++++ + +g+t+ hy a+ g++  +k +++   +               ++n+g+t+  ++ r++ + ++++L e  
  EFC37484.1 463 MMEHLV-HFNAQDrDGLTVAHYYAQFGQISKLKSIIAildKlptvaerkyflnfniTNNQGETAVDICYRYKMFALLRYLAEIA 545
                 667776.33333358************6642344443332233333344454447777************99999999998654 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.056   1.7e+02      28      45 ..     386     402 ..     376     411 .. 0.80
   2 !    9.4   0.0   0.00053       1.6      22      49 ..     465     491 ..     450     500 .. 0.87
   3 !    6.7   0.1    0.0037        11       6      44 ..     482     531 ..     482     542 .. 0.68

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.056
       Ank_4  28 naqdnrsGetalhiAakr 45 
                 +   +++G++ lh+A+++
  EFC37484.1 386 DLK-DIQGFNILHMAISG 402
                 454.99*********975 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00053
       Ank_4  22 ekgadinaqdnrsGetalhiAakrgnve 49 
                 e+ +  naq +r+G+t  h+ a++g+++
  EFC37484.1 465 EHLVHFNAQ-DRDGLTVAHYYAQFGQIS 491
                 88999****.**************9975 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0037
       Ank_4   6 hyaaisgrlelvrlLl............ekgadinaqdnrsGetalhiAak 44 
                 hy a++g++  +++++             +  + n + n++Geta++i+ +
  EFC37484.1 482 HYYAQFGQISKLKSIIaildklptvaerKYFLNFNIT-NNQGETAVDICYR 531
                 5666666666666666666666666544567889**9.*********9855 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.0    0.0066        20       7      26 ..     383     402 ..     381     423 .. 0.88
   2 !    8.3   0.1     0.001         3      12      56 .]     473     529 ..     463     529 .. 0.62

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0066
       Ank_5   7 advnrldgggntpLhvAaky 26 
                  d++ +d  g+++Lh+A+++
  EFC37484.1 383 LDTDLKDIQGFNILHMAISG 402
                 678899999*********96 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.001
       Ank_5  12 ldgggntpLhvAakygaadvvrlLl............argadlnltdsrGltaldlA 56 
                 +d++g t+ h+ a  g  + ++ ++            ++ ++ n+t+++G+ta+d++
  EFC37484.1 473 QDRDGLTVAHYYAQFGQISKLKSIIaildklptvaerKYFLNFNITNNQGETAVDIC 529
                 555555555555555555544444444455555544455569999999999999985 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.1   5.5e-06     0.016       5      39 ..      20      74 ..      16      77 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 5.5e-06
                HS-HH...................HHHHHHHTS-HHH.HHHHCTT-HHHHHHHTT CS
       F-box  5 rLPse...................vlrhILerLplsd.llalrrVSkgwrilids 39
                + P++                   v   IL++Lp++  l+ l rVS +w+ l+ +
  EFC37484.1 20 SIPNDdhhqeiklwsefmnrvgldVFQFILSFLPPIPyLFQLKRVSSHWKELCEE 74
                5555555555555555555555559999************************975 PP

>> AP_endonuc_2  Xylose isomerase-like TIM barrel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.0   0.00074       2.2      65     126 ..      23      81 ..       3      84 .. 0.86
   2 ?    3.7   0.0     0.012        37     109     154 ..     534     579 ..     467     582 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00074
                   HHHHHHHHHHHHHHHHHHTBSEEEEEBCCGBCTTTSGHHHHHHHHHHHHHHHHHHHHHHTSE CS
  AP_endonuc_2  65 reesvdalkraielaaaLGapllvlhpGtagagpkgseeeawerlaeslneladyaekegvk 126
                    +++ +++k + e+++++G ++ ++  +   ++p+ ++  +++r+ ++++el++++ ke+++
    EFC37484.1  23 NDDHHQEIKLWSEFMNRVGLDVFQFILS---FLPPIPYLFQLKRVSSHWKELCEECMKEDCT 81 
                   4788999*******************99...*************************999986 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.012
                   HHHHHHHHHHHHHHHTSEEEEE--TTTTSSSTCHHHHHHHHHHTTT CS
  AP_endonuc_2 109 laeslneladyaekegvklalEtlagsgvelgdeelarlldavdsp 154
                   + + l+ la++a +++++ + E l+++ v +  + +++++++++++
    EFC37484.1 534 MFALLRYLAEIAPRYDIQNIPEKLPEEIVLTTEDFAKAFVQKTPPK 579
                   666799**********************999989999999999965 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.1   0.00019      0.56       9      37 ..      45      74 ..      42      77 .. 0.83
   2 ?   -2.2   0.1       1.3   3.9e+03       3      10 ..     556     563 ..     555     564 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00019
  F-box-like  9 LlqIFsyLpps.dLlrlalVCrrWrrvald 37
                   I+s+Lpp   L +l +V+++W++++  
  EFC37484.1 45 FQFILSFLPPIpYLFQLKRVSSHWKELCEE 74
                5669****76658**************965 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.3
  F-box-like   3 rLPdEiLl 10 
                  LP+Ei l
  EFC37484.1 556 KLPEEIVL 563
                 6*****87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (589 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       807  (0.0450109); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.50u 0.24s 00:00:00.74 Elapsed: 00:00:00.41
# Mc/sec: 4332.65
//
Query:       EFC37485.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0058   16.3  12.7      0.011   15.4  12.7    1.4  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4  12.7   5.9e-07     0.011      62     123 ..     109     174 ..      82     197 .. 0.56

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 5.9e-07
       SR-25  62 rssssssssssssssssssssssssdd....rkkrgkkkdkkkkkkkkkkkkkkekkkakekakae 123
                 ++ss+ss s  s    s++++ssss++    ++ +  +k+kk+ kk k+ ++k   k+ak+++  +
  EFC37485.1 109 PTSSTSSASYQSQDVISTGAASSSSNKestfDQSTFVQKKKKSSKKAKQDEEKTVNKRAKKNSADD 174
                 223333333333333344444444444566656666666666666666677777777777644433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2727  (0.1521); expected 358.6 (0.02)
Passed bias filter:                      531  (0.0296168); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 1918.27
//
Query:       EFC37486.1  [L=1094]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.05   12.8   0.2        0.1   11.8   0.2    1.4  1  DUF692    Protein of unknown function (DUF692)
       0.43   10.9   9.1        2.8    8.3   1.8    4.1  3  DUF5601   Domain of unknown function (DUF5601)


Domain annotation for each model (and alignments):
>> DUF692  Protein of unknown function (DUF692)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   1.1e-05       0.1     118     203 ..     821     908 ..     814     931 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.1e-05
      DUF692 118 erikqvqdiLerplllEnvssylafpeselsEaeFlaelvertgcglllDvnNvyvnavNhgfdp..eayldalplervaeiHlAGhe 203
                 ++i++v d L+  l +En+s+ l+   ++++  e +++l+++   +ll  v+   ++  N++      a +++ p   +++  +AG +
  EFC37486.1 821 KQINEVVDKLNSILTVENLSYSLTSLMKKIDKNEKYEKLTDEMKEKLLETVTEYIASIKNNDSREiaLAKVAKNPNTFIEYATIAGLK 908
                 689**************************************************9999999985542278899999999****999983 PP

>> DUF5601  Domain of unknown function (DUF5601)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.65   5.8e+03      31      59 ..     416     440 ..     409     443 .. 0.65
   2 ?    4.5   0.2     0.005        45      24      57 ..     563     596 ..     536     598 .. 0.90
   3 ?    8.3   1.8   0.00031       2.8       1      60 [.     821     875 ..     821     878 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.65
     DUF5601  31 laerlnktplyktvsseavedlldeiEky 59 
                 l+ ++++t       s++ e l+d+ E +
  EFC37486.1 416 LNAKIEQT----KTVSPTYEVLMDGNEAF 440
                 34444444....35678999999998866 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.005
     DUF5601  24 VqdFyqnlaerlnktplyktvsseavedlldeiE 57 
                 + d+  +l+e l+ t+ +++++s +++++ d +E
  EFC37486.1 563 ICDYADKLSEFLRDTEKIQSLKSSEKDKIKDLLE 596
                 6689999************************999 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00031
     DUF5601   1 KqiksfvrkisqrsisieelSemVqdFyqnlaerlnktplyktvsseavedlldeiEkyi 60 
                 Kqi+++v+k+ +  +++e+lS      +++l ++++k++ y+ +++e +e+ll+ +  yi
  EFC37486.1 821 KQINEVVDKLNS-ILTVENLSY----SLTSLMKKIDKNEKYEKLTDEMKEKLLETVTEYI 875
                 777777777754.344677775....4789************************998888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1094 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1599  (0.0891851); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.90u 0.31s 00:00:01.21 Elapsed: 00:00:00.53
# Mc/sec: 6247.24
//
Query:       EFC37487.1  [L=985]
Description: hydantoinase/oxoprolinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   1.1e-115  386.3   0.0     2e-115  385.4   0.0    1.4  1  DUF917          Protein of unknown function (DUF917)
      2e-34  119.2   3.3    3.3e-31  108.6   0.2    3.1  2  Hydantoinase_A  Hydantoinase/oxoprolinase
    1.3e-25   90.1   0.1    2.3e-24   86.0   0.0    2.9  3  Hydant_A_N      Hydantoinase/oxoprolinase N-terminal region
    1.1e-07   30.8   2.4     0.0083   14.8   0.1    3.1  3  MutL            MutL protein
    0.00018   21.1   0.1      0.098   12.1   0.0    2.5  2  BcrAD_BadFG     BadF/BadG/BcrA/BcrD ATPase family
    0.00026   21.3   0.3       0.43   11.0   0.0    3.7  4  FtsA            Cell division protein FtsA
  ------ inclusion threshold ------
      0.055   12.9   0.2       0.13   11.7   0.2    1.7  1  ROK             ROK family
      0.068   12.4   7.4        5.7    6.1   0.0    3.9  4  StbA            StbA protein
       0.13   12.0   0.0        1.6    8.5   0.0    2.4  2  FAD_binding_4   FAD binding domain
       0.26   10.1   4.0        5.4    5.7   0.1    3.1  3  MreB_Mbl        MreB/Mbl protein


Domain annotation for each model (and alignments):
>> DUF917  Protein of unknown function (DUF917)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  385.4   0.0  1.1e-118    2e-115       1     343 [.     610     967 ..     610     974 .. 0.95

  Alignments for each domain:
  == domain 1  score: 385.4 bits;  conditional E-value: 1.1e-118
                 GGHHHHHHHHHHTTTT-SS-HHHHHHHHTT-SBTT--EEEE-GGG--SEE..EEEEEEE-HHHHTT-SS-HH....HHHHHHHHHT--EEEEE-SSSSC CS
      DUF917   1 edlealatGaavLGtGGGGspysgylllrqaleegksvrvvsldelpddalvvvvgamGsptvieeklpsgdelleavealekllgrkidavislEiGG 99 
                 +d++++ +G++v ++GGGGsp+++++l+r++l++gk+++++s++++++da+v++v++mG+p vi+ek    +e+l a+e++++++++ki+a++++EiGG
  EFC37487.1 610 TDIDCIEIGSGVVSSGGGGSPKQSAVLARSLLSHGKEIKIISPESIAEDAFVLPVAMMGAPLVIQEKS-IVEEFLPAIESMSNFTKKKIEAIFCIEIGG 707
                 69*******************************9988******************************9.8899************************** PP

                 CHHHHHHHHHHHHT-EEESB-SSSS--SSGGGSHHHHTT----SEEEE-SSS-EEEEEE...---HH.HHHHHHHHCTTTTTEEEEEEEEE-HHHHHH- CS
      DUF917 100 lNglvallaaaklglpvvDaDgmGRAfPelqqttfavagisltPlaladekgnvvllkka..qsdka.vErllRaalvemgsfagvaaypmtgaelkra 195
                 +N++++ll+aa +glpvvD+DgmGRA+Pel+++t +++g+s++P++l d+++n+vl++++  +++ + +E++lR+++v+mgs++g++ +p++++el ++
  EFC37487.1 708 SNSITPLLIAATSGLPVVDCDGMGRAYPELDMVTHFIDGCSPVPTMLLDDMNNQVLITSVnpRNPCKgLESILRPIAVQMGSMSGIILNPISKKELMQS 806
                 ***********************************************************844344456******************************* PP

                 -SBSHHHHHHHHHHHHHTT--...-SHHHHHHHHHH-EEEEEEEEE--------------EEEET.......EEEEEEESSSEEEEE..ET........ CS
      DUF917 196 avpgtlslalriGravaeareak.dvveailealgggakvlfkGkivdverrteggfdvgevtiegldedegrelkiefqNEnllaeedge........ 285
                 +v++++s +++iG+ + ea++++ d++++il++ + g   +f+Gki+dv+r+t++gf++g+++i+gl++d+g+ + +efqNE+l a+  +         
  EFC37487.1 807 TVHNSYSGVWSIGKGILEAHSQSlDPIQTILNSNN-GDL-FFSGKISDVNRKTTSGFNIGKCVISGLGKDQGKICIVEFQNEFLRAVIVKDydpsleti 903
                 ********************9945***********.566.********************************************999443356778888 PP

                 ......-SEETTSEEEEEHHB-SSSSB-TTTT.TS-EEEEEE---GGGS..SHHHH-S-....- CS
      DUF917 286 ......vlatvPDlIsvldaetgepigteelryGlrVtVlalpasekwrteeglelvgPkaFGy 343
                        la+vP++Is++d++tg +i+teelryG r++Vl+l   +k++t++gl++vgP+aFGy
  EFC37487.1 904 pqesiqSLAIVPNIISIVDSQTGLAIQTEELRYGFRISVLVLGGTPKFHTPKGLKTVGPTAFGY 967
                 888999*********************************************************9 PP

>> Hydantoinase_A  Hydantoinase/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.3   0.00043      0.76      81     100 ..       9      28 ..       7      56 .. 0.81
   2 !  108.6   0.2   1.8e-34   3.3e-31       1     288 [.     211     477 ..     211     480 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00043
  Hydantoinase_A  81 vItfDmGGTstDvslikdge 100
                     +I++D+G+T+tD++li+   
      EFC37487.1   9 IIGIDVGSTTTDCALINYSA 28 
                     79************998444 PP

  == domain 2  score: 108.6 bits;  conditional E-value: 1.8e-34
  Hydantoinase_A   1 rtetavvnAylspilreylesvekslekrgakarlmvmqsdGglvsadearkkpvetilSGPaaGvvgaaatsklagekkvItfDmGGTstDvsl 95 
                     r +++++nA+l+ + r+    ++++++ +  ++++++ q dG l++ + +++ p+ ti SGP  +  gaa    l g++++I++D+GG +tDv +
      EFC37487.1 211 RENASILNACLKGVSRSICYAFQEAIRSK-YACPFFLTQNDGTLIPPNLVTEFPIFTIQSGPTNSMKGAAF---LSGVENAIVVDIGGLTTDVGV 301
                     77899**********************96.67***************************************...********************* PP

  Hydantoinase_A  96 ikdgevevsle.teiagvkvrlpaldirtvgagGgsilvvd...eggklrvgpesagadpgpacyrkGgteltvTDanlvLGrlqpedflsgpdg 186
                     + +g ++ s++   i++v++++++ d+ +v++gGgsi+ ++   e++++++gp+s+g +    + + Gg+++t+TDa++ LG l++ +       
      EFC37487.1 302 LVNGFPRLSNNnVSIGNVPTNFRVPDVYSVAMGGGSIVSFNeneENSSIQIGPKSVGFNIFTESLSYGGNTVTTTDAAVALGLLKNCEWG----- 391
                     ******987651567***********************65511145689*************************************9887..... PP

  Hydantoinase_A 187 dqkldvelarrafeelakelnlkveevAegilsvavenmanavrklsvergldpkeltlvvfGGaGaqhaaalaeelgvkkvivppyagvlsalG 281
                        +  el+ +  + l+k+        A +i+++  + + +a++ +    +   ++ + v   G+G +++ +  +  gv+k+i p++ + ++a+G
      EFC37487.1 392 ---ASPELLSQTTQRLGKR--------APQIVDKIHSIVEEAIDHV----KIA-STNVPVLLVGGGSSLIDENRKFEGVSKIIKPKHYQCANAVG 470
                     ...5667777777777776........589999999999999**99....333.44444444555667788888999*********99******* PP

  Hydantoinase_A 282 malAdvr 288
                     +al dv+
      EFC37487.1 471 AALCDVS 477
                     ***9986 PP

>> Hydant_A_N  Hydantoinase/oxoprolinase N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.0   0.0   1.3e-27   2.3e-24       2     176 ..      10     187 ..       9     189 .. 0.88
   2 ?    0.3   0.1      0.28     5e+02       2      17 ..     288     303 ..     287     332 .. 0.77
   3 ?   -3.9   0.0       5.5   9.9e+03     124     156 ..     882     914 ..     881     915 .. 0.82

  Alignments for each domain:
  == domain 1  score: 86.0 bits;  conditional E-value: 1.3e-27
  Hydant_A_N   2 igIDvGGTfTDavaldeke..eevavlKllstpdavaegirealeevleesipr......tskidvvrmGTTvatNallerkg..ervaLittkgfrdl 90 
                 igIDvG+T TD+ +++      + +++K++++  ++++gi++a+++v+  + ++      ++ki  v++GTT+++Na+l      e+va++      + 
  EFC37487.1  10 IGIDVGSTTTDCALINYSAgnIVEHSIKTQTS-PDITSGIMKAIDQVMMMKNDQqvsgqrKGKILCVIIGTTHFVNAILSFSPdlEKVAVCRLGSSANN 107
                 8************9997774455578899998.99************9887777889999*******************988777******99988877 PP

  Hydant_A_N  91 leigrqnrpdlfelrikkplvlyeevvevderveadgevlkpldeeevrealkalkaagvesiavvllhSylnpehElrvaeiare 176
                      ++ p+     +  ++++  + +++d+++++dg+++ p+++++v++  ++lk+++ + i+++ ++S++n e+E++va+ +re
  EFC37487.1 108 SLPPCESFPER----L--KELVLGDYYKIDGGYQVDGREILPVNQDQVQQMCQSLKEKNLKNIVISGIFSPINSEQEKQVADWIRE 187
                 77776655555....3..466677889********************************************************998 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.28
  Hydant_A_N   2 igIDvGGTfTDavald 17 
                 i +D+GG  TD+ +l 
  EFC37487.1 288 IVVDIGGLTTDVGVLV 303
                 89*********97665 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 5.5
  Hydant_A_N 124 eadgevlkpldeeevrealkalkaagvesiavv 156
                 e++ e l+++  +    +l+ + ++ ++s+a+v
  EFC37487.1 882 EFQNEFLRAVIVKDYDPSLETIPQESIQSLAIV 914
                 56667777788888889999999999****997 PP

>> MutL  MutL protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.1   4.6e-06    0.0083       2      58 ..      10      62 ..       9     109 .. 0.76
   2 ?   -0.6   0.1      0.21   3.7e+02     159     205 ..     145     191 ..     141     210 .. 0.89
   3 !   14.0   0.0   7.7e-06     0.014     224     273 ..     267     311 ..     259     325 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.6e-06
        MutL  2 lviDiGSttTkvtlvdlekvderllgqaeapTtveeedvleGleealeeleeklgkt 58
                + iD+GSttT  +l++ ++  ++++ ++ +  t    d++ G+ +a++++   ++++
  EFC37487.1 10 IGIDVGSTTTDCALINYSA--GNIVEHSIKTQTS--PDITSGIMKAIDQVMMMKNDQ 62
                569**************77..9999988877777..5***********998776555 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.21
        MutL 159 NkaareeveeiLeeagkelvvtdNvlPkldelnveparkaIrevFle 205
                 N++  +++ + L+e++ + +v   ++  +++++ +++ + Ire F++
  EFC37487.1 145 NQDQVQQMCQSLKEKNLKNIVISGIFSPINSEQEKQVADWIREFFNH 191
                 78888899999*********************************964 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 7.7e-06
        MutL 224 impTPaAvlkavellaeeeekglgdllvvDvGGaTTdvhsvaegspekek 273
                 i+  P   +k++ +l+      +++++vvD+GG TTdv   ++g p+ ++
  EFC37487.1 267 IQSGPTNSMKGAAFLSG-----VENAIVVDIGGLTTDVGVLVNGFPRLSN 311
                 56678888999999988.....5699************988888777665 PP

>> BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   5.5e-05     0.098       1      30 [.      10      62 ..      10     239 .. 0.67
   2 !    6.4   0.0    0.0032       5.7     183     265 ..     400     473 ..     395     474 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.5e-05
                 EEEEE-SSEEEEEEEE.TTTEEEEEEEE--......................T CS
  BcrAD_BadFG  1 vGiDgGsTttkavlmd.ekgevlgrgitns......................a 30
                 +GiD+GsTtt ++l++   g+++   i++                       +
   EFC37487.1 10 IGIDVGSTTTDCALINySAGNIVEHSIKTQtspditsgimkaidqvmmmkndQ 62
                 7*************994556788877777655555555555555555555550 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0032
                  HHHHTT--HHHHHHHHHHHHHHHHHHHHHTT---SS.EEEESGGGG-HHHHHHH.....HHHH-S.-EE--GGGGGHHHHHHHH CS
  BcrAD_BadFG 183 dalsggekaedIlaglhraialrvialisrsggvtdevtltGGvakneaavkelrklvkenygev.kininpdsiytgalGAal 265
                  + + +g+ a +I++++h+ +++ +  +   s +v+  v+l+GG ++     +        ++ +v ki  +++++ + a+GAal
   EFC37487.1 400 TTQRLGKRAPQIVDKIHSIVEEAIDHVKIASTNVP--VLLVGGGSSLIDENR--------KFEGVsKIIKPKHYQCANAVGAAL 473
                  56789*************99999999999999995..999999998833333........344555899999**********98 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.0   0.00024      0.43       1      44 [.      10      55 ..      10     164 .. 0.87
   2 ?   -2.3   0.0       3.4   6.2e+03      35      52 ..     222     239 ..     215     276 .. 0.82
   3 !    5.9   0.1    0.0094        17       1      21 [.     288     308 ..     288     324 .. 0.84
   4 ?   -3.2   0.0       6.5   1.2e+04      21      41 ..     361     382 ..     352     387 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00024
                EEEEE-SSSEEEEEEETTE..EEEEEEES-.-HHHHHHHHHHHHT-- CS
                xxxxxxxxxxxxxxxxxxx..xxxxxxxxx.xxxxxxxxxxxxxxxx RF
        FtsA  1 alvDiGagktdvavaedga..lvhlrvigv.ggngitkdiakalrta 44
                +++D+G+++td+a+++ +a  +v  ++i++  +  it++i+ka+ + 
  EFC37487.1 10 IGIDVGSTTTDCALINYSAgnIVE-HSIKTqTSPDITSGIMKAIDQV 55
                58**********998775432444.4444459999999999998765 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 3.4
                 HHHHHHHT--HHHHHHHH CS
                 xxxxxxxxxxxxxxxxxx RF
        FtsA  35 kdiakalrtaveeAerik 52 
                 k++++++  a++eA r k
  EFC37487.1 222 KGVSRSICYAFQEAIRSK 239
                 678999999999999888 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0094
                 EEEEE-SSSEEEEEEETTEEE CS
                 xxxxxxxxxxxxxxxxxxxxx RF
        FtsA   1 alvDiGagktdvavaedgalv 21 
                 ++vDiG+ +tdv v+ +g ++
  EFC37487.1 288 IVVDIGGLTTDVGVLVNGFPR 308
                 69*************998655 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 6.5
                 EEEEEES--HHHHHHH.HHHHH CS
                 xxxxxxxxxxxxxxxx.xxxxx RF
        FtsA  21 vhlrvigvggngitkd.iakal 41 
                 ++++++ +ggn +t   +a al
  EFC37487.1 361 IFTESLSYGGNTVTTTdAAVAL 382
                 4588899999999875566655 PP

>> ROK  ROK family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.2   7.4e-05      0.13       2      53 ..      10      62 ..       9      88 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7.4e-05
                EEEEE-SSEEEEEEEETT.S-EEEEEEEEEHCCHHCCHHHHHHHHHHCCCHCC CS
         ROK  2 igidiGgtkialalvdee.geilarekvetptetteetlvdaiaelvdeaerk 53
                igid+G t + +al++ + g+i+++    ++ +++  ++++ai++++ +++++
  EFC37487.1 10 IGIDVGSTTTDCALINYSaGNIVEHSIKTQTSPDITSGIMKAIDQVMMMKNDQ 62
                8**************96516666555556788888889999999976655443 PP

>> StbA  StbA protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.3     0.027        48     168     211 ..      12      58 ..       6      72 .. 0.62
   2 ?    6.1   0.0    0.0032       5.7     156     185 ..     278     307 ..     268     317 .. 0.79
   3 ?    4.8   0.0    0.0077        14     254     290 ..     414     450 ..     393     474 .. 0.71
   4 ?   -2.5   0.0       1.3   2.3e+03     138     174 ..     672     709 ..     666     729 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.027
        StbA 168 iDlGGttLDvakvrgklegiskvkgdskiG...vslitdavkealet 211
                 iD+G tt D+a ++    +i +   + ++    +s i++a+ +++ +
  EFC37487.1  12 IDVGSTTTDCALINYSAGNIVEHSIKTQTSpdiTSGIMKAIDQVMMM 58 
                 8************9877777654443333211134444455544443 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0032
        StbA 156 lkeldeleslLiiDlGGttLDvakvrgkle 185
                  + l+ +e+ +++D+GG t Dv+ +   + 
  EFC37487.1 278 AAFLSGVENAIVVDIGGLTTDVGVLVNGFP 307
                 4458999***************98776655 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.0077
        StbA 254 kvkkLkerviravsefsgythvmvvGGGaeliaeaik 290
                 k +++ e+ i++v+  s    v++vGGG++li e  k
  EFC37487.1 414 KIHSIVEEAIDHVKIASTNVPVLLVGGGSSLIDENRK 450
                 444555556666666677777***********88633 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 1.3
        StbA 138 tikkvkvlPeslPagfealke.ldeleslLiiDlGGtt 174
                 +i++ +++ e lPa  +  +   +++e    i++GG  
  EFC37487.1 672 VIQEKSIVEEFLPAIESMSNFtKKKIEAIFCIEIGGSN 709
                 6788889999999988877764678999999***9975 PP

>> FAD_binding_4  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.32   5.8e+02       5      37 ..     141     173 ..     139     192 .. 0.84
   2 ?    8.5   0.0   0.00088       1.6      11      45 ..     420     453 ..     409     455 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.32
                    EEESSHHHHHHHHHHHHHCTSCEEEESSSTTEE CS
  FAD_binding_4   5 vrpeseeevaaalrlaneaglpvlvrGgGssll 37 
                    + p ++++v+  ++  +e++l+ +v++g  s +
     EFC37487.1 141 ILPVNQDQVQQMCQSLKEKNLKNIVISGIFSPI 173
                    67999*****************99999866665 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00088
                    HHHHHHHHHHHHCTSCEEEESSSTTEESTTCSCCE CS
  FAD_binding_4  11 eevaaalrlaneaglpvlvrGgGssllgqavatgg 45 
                    ee ++ +++a+ +++pvl +GgGssl++++ +++g
     EFC37487.1 420 EEAIDHVKIAS-TNVPVLLVGGGSSLIDENRKFEG 453
                    67777788877.89************977655655 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.4     0.015        26     150     175 ..      12      38 ..       6      81 .. 0.74
   2 ?    5.7   0.1     0.003       5.4     146     163 ..     286     303 ..     280     315 .. 0.88
   3 ?   -0.6   0.0      0.26   4.7e+02     247     288 ..     405     446 ..     397     467 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.015
                 EEE-SS-EEEEEE..ETTEEEEEEEES- CS
    MreB_Mbl 150 vdiGggttevavi..slggivtsksvrv 175
                 +d+G+ tt++a+i  s+g+iv+  s+++
  EFC37487.1  12 IDVGSTTTDCALInySAGNIVEH-SIKT 38 
                 8***********96667788765.6765 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.003
                 -EEEEEE-SS-EEEEEEE CS
    MreB_Mbl 146 gnmvvdiGggttevavis 163
                   +vvdiGg tt+v v+ 
  EFC37487.1 286 NAIVVDIGGLTTDVGVLV 303
                 579*************96 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.26
                 HHHHHHHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBT CS
    MreB_Mbl 247 kepvsaiveavkevLektppeLaadivdrgivltGGgallkg 288
                  +   +iv++++++ e++        ++  ++l+GGg+ l +
  EFC37487.1 405 GKRAPQIVDKIHSIVEEAIDHVKIASTNVPVLLVGGGSSLID 446
                 556678999999999999999999999999999999998865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (985 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       724  (0.0403815); expected 358.6 (0.02)
Passed bias filter:                      598  (0.0333538); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.91u 0.32s 00:00:01.23 Elapsed: 00:00:00.51
# Mc/sec: 5785.22
//
Query:       EFC37488.1  [L=900]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (900 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       598  (0.0333538); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.74u 0.31s 00:00:01.05 Elapsed: 00:00:00.53
# Mc/sec: 5152.45
//
Query:       EFC37489.1  [L=1796]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-36  126.3   0.0    6.2e-36  124.5   0.0    2.0  1  PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase
      6e-06   25.8   4.0      6e-06   25.8   4.0    2.9  2  PI3Ka           Phosphoinositide 3-kinase family, accessory d


Domain annotation for each model (and alignments):
>> PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  124.5   0.0   6.9e-40   6.2e-36       2     237 ..    1476    1702 ..    1475    1707 .. 0.85

  Alignments for each domain:
  == domain 1  score: 124.5 bits;  conditional E-value: 6.9e-40
                      EEEEEECSSCHHHHHHHHHHHHHHHHHHHHTTTTCCCT-------EEESSS...SEEEEE--TTEEEHHHHHHHHHHHCTTSTCHHHHHHHHH CS
  PI3_PI4_kinase    2 sagiykvgddlrqdelivqvfklmdeelskennpkrrklalktysviplgr...kcgiielvassetaaslldeklekkgvpptasveslrva 91  
                      +++i+k gddlrqde i+q+f+lm+ +l++++  +     + ty ++++++   ++g++e+v +s ++  +l +++        + +++lr +
      EFC37489.1 1476 YKIIFKQGDDLRQDEYILQLFTLMNRILKQNGINLE----IVTYHCVSTSQsplNSGFVEMVSQSNAVSAILAKYK--------TIFNFLRET 1556
                      899********************************8....9999999999733469******************98........567774444 PP

                      CHCHCCHHHHHCCHHHHHHTSSTTHHHHHHHHHSSSHH..........HHHHHHHHHHHHHHHHHHHHHHHT-TT--TTTEEEETTTSEEEES CS
  PI3_PI4_kinase   92 ldkkklkkekklkfekrtalkpksgllqeFvkkspsae..........ewlearkqFvrslaklsvldyilgngDRhldNilvdktsgklihI 174 
                      ++k+k + +     + ++ ++p +++  + +  ++++e           + e + +++rsla++svl+y+l +gDRhldN+l+ k+sg+l+hI
      EFC37489.1 1557 SKKEKPADK-----KDEIIENPDEDSSGSTTGPASEYEpvsgeiidvlVFEEKIHKYIRSLAGYSVLTYVLAIGDRHLDNLLL-KESGELFHI 1643
                      444444433.....456777777777777777777776666667766688888******************************.********* PP

                      STTTCCTCSHCSSSS.-.SSSSSS-THHHHHHTSTTCCHHHHHHHHHHHHHHHHHTHHHHHHHH CS
  PI3_PI4_kinase  175 DfGlilpdewkllpf.pqekvPfrltrelvlaidpskdeglfresceealealrrdqnlltrll 237 
                      DfG+ l++++k++   p    P+r  re+v+ +   ++   fr +c++++++lr+ + l++ +l
      EFC37489.1 1644 DFGFVLGEDPKAYLGtP----PMRISREMVADF-SEEHLSAFRMYCCQTFKVLRKYASLIIYML 1702
                      ******99888875448....************.89999*****************99998776 PP

>> PI3Ka  Phosphoinositide 3-kinase family, accessory domain (PIK domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.3      0.22   1.9e+03     113     175 ..     480     556 ..     465     565 .. 0.69
   2 !   25.8   4.0   6.7e-10     6e-06      16     181 ..    1099    1292 ..    1096    1296 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.22
                 HHHHHHHHGGS................SSSSSHHHHHHHHHHHHSHHHHHHHHHHHHHHHHCCTHHHHHHHHHHHHHHH CS
       PI3Ka 113 llQLVqalkye................pikdsalaefLlkralknkrlghfffWyLkseiedkevserfksllesylrk 175
                 l Q+V+ +k e                + ++ +l++fL++  l+ kr   +++ +L+  ++ + + +++k++l+ ++++
  EFC37489.1 480 LTQVVKWMKLElffealiswcvinmnsKRNIQKLNRFLIQEELIKKR--TEIYSFLEKKSNCQFLVKNLKRSLDMIVDN 556
                 66777777777888888888888887777888999999999888877..456666665555555555555555555555 PP

  == domain 2  score: 25.8 bits;  conditional E-value: 6.7e-10
                  HCHS-TTS---HHHHHHHHHTHHHHCTSGGGHHHHHTTS-SSSHHHHHHH.HHHHTT......SHHTTHHHHTTTTSTTS........--...HHHH CS
       PI3Ka   16 iiakdPltkltaeekeliwkfryylknnkkaltklLqsvkwseesevkea.lellds......WaeididdaLeLLdskf........kd...esvr 94  
                  ++++d  +++t  +  +++k+r +l +++k    +++s++w+   +  e+ l ll +        + ++ + L  L  +f        ++   esv+
  EFC37489.1 1099 VVNTDNYSSITDTQTYVLFKYRKVLCREPKLFLFMIRSINWKGDYKTGEElLDLLIKemkesqKHPFSPMHKLTTLHIMFlihetviaSKidlESVQ 1195
                  678899999*************9999*******99******97666555515554334554554446777766666666643333332113468999 PP

                  HHHHHHHHHSHHHHHHHHHHHH...HHHHGGSSSSSSHHHHHHHHHHHHSHHHHHHHHHHHHHHH...........HCCTHHHHHHHHHHHHHHHCH CS
       PI3Ka   95 eyavkvLekasdeelllYllQL...VqalkyepikdsalaefLlkralknkrlghfffWyLksei...........edkevserfksllesylrkls 177 
                   ++v+vL++ +  e++  l+Q+     a+ky     s l efLl+   k+  + +++ W L+s +            dk+ +  +k+l  ++++++ 
  EFC37489.1 1196 IFSVQVLRQRKITEIETLLPQIfyiMGATKYY----SHLMEFLLEACDKSEYIFNKLNWMLTSMLnsntvrglernTDKKANTAYKQLHFKMIKNCA 1288
                  *********************73325678887....*************************998877889999888788888899999999999998 PP

                  HHHH CS
       PI3Ka  178 kslk 181 
                  +s +
  EFC37489.1 1289 QSEL 1292
                  8765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1796 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1301  (0.072564); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.06u 0.34s 00:00:01.40 Elapsed: 00:00:00.56
# Mc/sec: 9631.53
//
Query:       EFC37490.1  [L=377]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-12   48.9   2.5    1.8e-12   48.2   2.5    1.4  1  Metallophos    Calcineurin-like phosphoesterase
      5e-08   33.3   3.4    1.4e-07   31.8   1.7    2.4  2  Metallophos_2  Calcineurin-like phosphoesterase superfamily d
  ------ inclusion threshold ------
      0.032   13.9   1.0      0.054   13.1   0.2    1.7  2  CBAH           Linear amide C-N hydrolases, choloylglycine hy
      0.049   14.4   0.0       0.15   12.9   0.0    1.8  1  GARS_N         Phosphoribosylglycinamide synthetase, N domain
        0.1   12.4   0.1       0.28   10.9   0.1    1.7  1  RRM            Putative RRM domain


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.2   2.5   5.1e-16   1.8e-12       2     204 .]      98     309 ..      97     309 .. 0.76

  Alignments for each domain:
  == domain 1  score: 48.2 bits;  conditional E-value: 5.1e-16
                  EEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSS....HHHHHHHHHHHHHHHH...TSEEEEEC-TTSCHHHHHHHHHHHHHHHH CS
  Metallophos   2 rilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrg....dlekellellaalvky...pipvylllGNHegfeeellnkygylgifs 92 
                  r++vi+D H      + ++  + +      +k+d+vl++GD+ +      d+++ +++l aa++k+     +++++ GNH+ ++ ++ +    +++ s
   EFC37490.1  98 RFAVISDSH-----CGESKWYTKI------PKVDVVLHCGDFSQNDhgpnDVQQ-FNNL-AAKLKNdgkCSQIVCIGGNHD-YHLDYRRNSSLSNEKS 181
                  899******.....8887777777......788********8888766555555.5555.6666664676667********.6669999999999999 PP

                  HHHEHHHCEEETSEEEEEETTEEEEEEEESECEEETHHHHHHHHHHHSCHHHHCC.HHHHHHHHHHTTCSEEEEEESSESS................. CS
  Metallophos  93 epwrsdaevfnnlplaslgsgslkvlllhGgspellvsldklgslnleleapepg.dewlkdlekrekadwvivlgHsply................. 172
                   +  +++++   l  +++  +  ++ ++  gs+++  + ++++ +++ + a+++  ++++ +     ++d +iv++H p+y                 
   EFC37490.1 182 IDMIMNQKKHPLLSNVDYYLQ--NTSIILDGSIRI--FGCPITPFDMAFGASDHVsYDIYTQ---CMDNDCDIVMTHNPPYnildlagmgstqgicpt 272
                  999999888888888888888..777777777888..7888888888888877778888888...8999************99999999998766665 PP

                  ....CSSSCSCCHHHHH.HHHHHTTESEEEEESSSSE CS
  Metallophos 173 ....rgsgylfgdeale.dllkkygvdlvisGHtHvy 204
                           ++g+  l+  l  + ++ + ++GH+H++
   EFC37490.1 273 cktnHPHAAHWGNFWLRnQLIHRVKPTVSVFGHVHEC 309
                  55543333333333333555888889999******85 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.3   8.3e+03      43      61 ..      74      92 ..      56      93 .. 0.64
   2 !   31.8   1.7     4e-11   1.4e-07       2      63 ..      98     179 ..      98     332 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.3
  Metallophos_2 43 evleellelapvlaVrGNn 61
                   e++e +++ +++ +VrG n
     EFC37490.1 74 EIVEIFEKDFKIAVVRGGN 92
                   3455555555888888755 PP

  == domain 2  score: 31.8 bits;  conditional E-value: 4e-11
  Metallophos_2   2 klaiiSDlHsnldaleavlealkevgvdaiihaGDl..eeeepevleellela..........pvlaVrGNnD.............e 63 
                    ++a+iSD+H       ++++++ +v  d ++h+GD+  ++  p+ ++++ +la          +++ + GN+D             e
     EFC37490.1  98 RFAVISDSH---CGESKWYTKIPKV--DVVLHCGDFsqNDHGPNDVQQFNNLAaklkndgkcsQIVCIGGNHDyhldyrrnsslsnE 179
                    689******...57789********..*********99999999*****9999999*****************65555555444430 PP

>> CBAH  Linear amide C-N hydrolases, choloylglycine hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.81   2.9e+03     270     284 ..     230     244 ..     222     256 .. 0.81
   2 ?   13.1   0.2   1.5e-05     0.054     232     293 ..     311     368 ..     306     374 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.81
                 S-B-EEEEEEEEETT CS
        CBAH 270 gklkyTvYtslidlt 284
                 +++ y +Yt ++d++
  EFC37490.1 230 DHVSYDIYTQCMDND 244
                 668899999999986 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 1.5e-05
                 HHHHHHCHHHCSHHHHHHHHHHHHHTT---TTSSB-TTS-B-EEEEEEEEETTTTEEEEEET CS
        CBAH 232 aylkkalekakqesesvakifdilssvavpkGavlneegklkyTvYtslidltkgqYyfely 293
                  y+kk +++ k+e+++ +++f+i +s +    ++l  ++++  T   +++d+  + Y+f++y
  EFC37490.1 311 GYVKKSIKELKEEEQQQKTLFNIQNSAN----LILGGDDRTPITFLNAAVDMYCKVYFFDFY 368
                 59**************************....566678889*******************98 PP

>> GARS_N  Phosphoribosylglycinamide synthetase, N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   4.2e-05      0.15      15      74 ..     144     204 ..     141     218 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.2e-05
                 HHHHHTTSTTESEEEEEE--CGG.TTHHHHHHHHHHCTESEEEE-SHHHHHTTHHHHHHHH CS
      GARS_N  15 lawklaqspkvekvyvapgNagt.edlealvefakeekidlvvvGpeapLvaGvadaleee 74 
                 la kl+++ k+++++++ gN+    d+++  ++ +e++id+++    +pL + v  +l+++
  EFC37490.1 144 LAAKLKNDGKCSQIVCIGGNHDYhLDYRRNSSLSNEKSIDMIMNQKKHPLLSNVDYYLQNT 204
                 899******************997677889999*********************9999766 PP

>> RRM  Putative RRM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   7.8e-05      0.28       5      16 ..     218     229 ..     216     229 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 7.8e-05
         RRM   5 PqTPFDlaYgas 16 
                 P+TPFD+a+gas
  EFC37490.1 218 PITPFDMAFGAS 229
                 9*********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2414.68
//
Query:       EFC37491.1  [L=165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1212  (0.0676); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.50
# Mc/sec: 1001.18
//
Query:       EFC37492.1  [L=163]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.4e-06   27.6 118.6    1.8e+04  -60.4 118.6    3.5  1  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -60.4 118.6         1   1.8e+04     111     111 ..      75      75 ..       1     163 [] 0.60

  Alignments for each domain:
  == domain 1  score: -60.4 bits;  conditional E-value: 1
  Trypan_PARP 111 p 111
                  p
   EFC37492.1  75 P 75 
                  1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       328  (0.0182944); expected 358.6 (0.02)
Passed bias filter:                      109  (0.00607954); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        38  (0.00211947); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.89u 0.36s 00:00:01.25 Elapsed: 00:00:00.53
# Mc/sec: 926.70
//
Query:       EFC37493.1  [L=802]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-35  122.4   1.0    4.3e-35  121.9   0.2    1.6  1  Peptidase_S10  Serine carboxypeptidase
  ------ inclusion threshold ------
       0.11   12.9  10.5       0.23   11.8  10.5    1.5  1  EGF_2          EGF-like domain


Domain annotation for each model (and alignments):
>> Peptidase_S10  Serine carboxypeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  121.9   0.2   4.8e-39   4.3e-35       7     396 ..      46     458 ..      37     460 .. 0.85

  Alignments for each domain:
  == domain 1  score: 121.9 bits;  conditional E-value: 4.8e-39
                    -SSEEEEEEEECSTTTTEEEEEEEEE-SS...GTTTS-EEEEE--TTTB-THHHHHHTTSSEEEETTTTSEEEE-TT-GGGCSEEEEE--STTSTT CS
  Peptidase_S10   7 vnfkqysGYldveeeedkslFYwfvesek...npeedplvlWLnGGPGCsSldGlleElGPfrvnkdstkkleenpysWnkvanvlfldqPvGvGF 99 
                    +  k+y+G l ++ + + +lFYw++ +++   n e+++l++ Ln GP C   + l+ E+G f+++   ++ l +n+ s ++ a+vl++d+P+G+G 
     EFC37493.1  46 PLPKSYAGNLPIR-SGKDRLFYWYFPKTNsniNDERKDLLVMLNRGPACYFAEMLFLENGVFQID--ANQVLTLNSKSFHQFAHVLYIDSPLGTGL 138
                    44699********.88999******999988889999****************************..679*************************9 PP

                    -EETTSSGS--SH.....................HHHHHHHHHHHHHHHHHSTCG....TTSEEEEEEETTHHHHHHHHHHHHHTHCCH--SSTSE CS
  Peptidase_S10 100 Sysntksdvktdd.....................eevaedlyefLkkffekfpey....ksrdfyitGESYaGhyvPalakeilkknkkekkkkin 170
                    S  +t+ + + +                      + v +dl ++L  ff+ fp++    k +++   +  Y+ +++P++ ke   + +    +k+ 
     EFC37493.1 139 SQFSTEVS-NFESygklmfpgnslrlktvfpgatKYVVKDLQDALIGFFTLFPHLspdkKGSTLNFYTPGYSAKMIPYFIKENSVGGSFT--TKFK 231
                    98888877.333345799**********************************998777777788888889*********99988888775..89** PP

                    EEEEEEESE-SBHHHHHCCHHHHHHHTTSSHHHHHHHHHHHHEET......HHHHHHHHHHHHHHHHHHHHHHHHHCHCEETTETTSEETTSSEEH CS
  Peptidase_S10 171 LkGlligNglideaeqvnsyvefayehgliseeeyeslkkacekk......eeleqesekcanllekaskvavekenkglnvynileeccklkael 260
                    ++++++g++++++  q+ sy++f y  gl   +++ +++++ e+        ++++++++c++l+  + +     + +++ +++i+e++  +++  
     EFC37493.1 232 ISSIILGDPFLQPSLQYASYAKFGYVSGLTMYRQFVEMNRKYEQCltdvenGNYNNYDKECHSLIAGLLE-----NSGNVSPFDIREQS--TQQ-Y 319
                    **********************************999999997768888888899999999999999987.....5689**********..222.2 PP

                    HHCTTCCCCTTTTTCHHHHHHHHTSHHHHHHTT--.TTSSS--SB-H.HHHHHCTCCC-SBCHHHHHHHHHTT-EEEEEEETT-STT-HHHHHHHH CS
  Peptidase_S10 261 kksstdaqggedpydesyvekylnkkeVrkalhvn.asvkkweecnd.svfeqleddisksveeileellesglrvliynGdvDlicnvlgteawi 354
                    ++ +   ++ +      +++++ + + V +  h + + ++ ++e  + +v +    +i ++ ++i +   +s++r+l+++ +  l+ nv+g ++++
     EFC37493.1 320 EQRQAVLNTYVNNDLLPALRSFGSIPTVVTIPHCSkKVNDLFHEEYHlDVPQDVFPSILNTNTPINSAYNTSNVRILVFSQQFNLVSNVFGVNEIL 415
                    2222223333333345677888888888888888854444454444448877777788888888888888899*********************** PP

                    HH.TECTTECCSCCCEEEETTTCESEEEEEEEETTEEEEEETT CS
  Peptidase_S10 355 kk.lelsgkkefrpwevspkkengqvaGyvkeyenltfltvkg 396
                    ++ l ++g+  f++ ++s+ + ++ ++G +k y++lt +  ++
     EFC37493.1 416 RQmLDWEGQLTFNSLNSSIFTIQDMIGGRFKAYGGLTQVVLYN 458
                    9989*********************************998775 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8  10.5   2.6e-05      0.23       1      32 []     525     553 ..     525     553 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.6e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C++    C+  GtC+ +  +CdC++gy+ ++C
  EFC37493.1 525 CPS---LCSKKGTCNLEKKKCDCQPGYYDNNC 553
                 764...5*******733337********9999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (802 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       822  (0.0458475); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.29s 00:00:01.03 Elapsed: 00:00:00.49
# Mc/sec: 4944.01
//
Query:       EFC37494.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0021   18.0   0.6      0.012   15.6   0.0    2.5  2  UB2H            Bifunctional transglycosylase second domain
  ------ inclusion threshold ------
       0.15   12.6   1.0       0.28   11.8   0.1    1.9  2  CHAP            CHAP domain
        1.8    7.7  32.7        2.2    7.4  32.7    1.2  1  SOG2            RAM signalling pathway protein
        5.3    6.9  18.9        6.4    6.6  18.9    1.1  1  TFIIA           Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> UB2H  Bifunctional transglycosylase second domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   1.1      0.82   3.7e+03      24      45 ..      74      95 ..      67      97 .. 0.81
   2 !   15.6   0.0   2.7e-06     0.012       7      35 ..     241     269 ..     236     272 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.82
        UB2H 24 vsnvtrpGeyavsgnriellrR 45
                +sn +rp +y+++ ++ + +rR
  EFC37494.1 74 TSNSRRPTSYNRRPTTTTNNRR 95
                48999******99988877776 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 2.7e-06
        UB2H   7 lsaaqleqeLellgYrkvsnvtrpGeyav 35 
                  sa+++  +L+++gY+kvs + +pG++++
  EFC37494.1 241 GSAKDFGSWLQKMGYQKVSGPMQPGDVQI 269
                 5899*********************9875 PP

>> CHAP  CHAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       1.8   7.9e+03      37      47 ..     150     159 ..     124     176 .. 0.58
   2 ?   11.8   0.1   6.3e-05      0.28       9      69 ..     217     283 ..     209     292 .. 0.63

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.8
                 EEEEEECSTBS CS
        CHAP  37 yknqanvgsst 47 
                 +++++n++s +
  EFC37494.1 150 FSQYRNTQS-K 159
                 333333333.2 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 6.3e-05
                 SHHHHHHHHHHHHS..........SSSSSSECTCCHHC.........EEEEEECSTBS--TTEEEEEETTTTBCT-EEEE CS
        CHAP   9 qCvefaywrlrqag..........gnaddWnnakkakg.........yknqanvgsstpkvGdivvfdrggeggyGHVai 69 
                  C+ + +  +++a           g+a+         +         y+    + s + ++Gd+ +f++ ++ + GH  +
  EFC37494.1 217 KCAKYTANAIEKALtgktytinrpGSAK---------DfgswlqkmgYQ----KVSGPMQPGDVQIFQAIPGHPDGHMQM 283
                 6999998887766553334444443344.........333433233366....5555779*******9988767999766 PP

>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4  32.7    0.0005       2.2     171     342 ..      44     224 ..      10     273 .. 0.48

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0005
        SOG2 171 ragrtksksisttssgssstlvssaesstesrassvtytartRhagsfsaqdveqGaaltplrsd.qipfnl........srsrrssssgnsaspaang 260
                 r ++++s+s   tss+s ++++ss + +  +++s +++  ++R+++  +  + + ++  +p +s+ +  +++         ++ r++s++n+ +p++++
  EFC37494.1  44 RSSSSSSSSRRPTSSSSYRRPTSSYNRRPTTSNSRRPTSYNRRPTTTTNNRRRPTSNTRRPTSSNnR-RQPTnrrptrptRTNVRNGSNNNRRKPSNSV 141
                 2333333333344444444444444444444444444333345555555554444444444444421.2222235555556777777777777777777 PP

        SOG2 261 aqsetsersasssgvqssasstPlgegstspp..galsrqslsttgststltsssksrs......ssrsntnasastprslattpappas 342
                 +  ++++r ++     ++ +s+P+g++++s+    +++rq ++t  ++++ ++  +s+       +s++++  sas ++s+ + ++ +a+
  EFC37494.1 142 RPGMSNQRFSQ----YRNTQSKPYGANTQSNQpaRQPTRQ-PTT--AQQPAQQNIRSTApssqvvQSAMSNVRSASHSQSQGKCAKYTAN 224
                 75554443333....2334444555555554111222222.212..22222221121112223443333333344444444444443333 PP

>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6  18.9    0.0014       6.4     103     246 ..      67     217 ..      22     267 .. 0.38

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0014
       TFIIA 103 slta....nssaataatfslpakleppvqipagvtlqtasgqlykvnvqasgaqqiaaqplqqvvqqsqgsaaqssvaalqaq.sqqaqalaepqqqle 196
                 s++     ++s+   + +  p++++ +   p++ t +++s     +n   + ++++ ++p  ++v ++++++  +  +++ ++ s+q  ++ ++ q + 
  EFC37494.1  67 SYNRrpttSNSRRPTSYNRRPTTTTNNRRRPTSNTRRPTS-----SNNRRQPTNRRPTRPTRTNVRNGSNNNRRKPSNSVRPGmSNQRFSQYRNTQSKP 160
                 1111111212212222222222222223333333333333.....223455555555566666655544444344444444443222222222222211 PP

       TFIIA 197 kqqqqqqqqqqqqqqqqvqqqqqe......esqqaqqasqeqvag.sqvessqtdga 246
                  ++++q +q+++q  +q ++ qq       + +  +q  q+++++ ++++ sq +g+
  EFC37494.1 161 YGANTQSNQPARQPTRQPTTAQQPaqqnirSTAPSSQVVQSAMSNvRSASHSQSQGK 217
                 112222222222222211111110000111111111111111111111112222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1462  (0.0815439); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.82u 0.36s 00:00:01.18 Elapsed: 00:00:00.47
# Mc/sec: 2070.84
//
Query:       EFC37495.1  [L=359]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.041   14.4   0.4        2.2    8.9   0.1    2.4  2  HSCB_C    HSCB C-terminal oligomerisation domain
      0.099   13.0   0.1        3.6    8.0   0.0    2.8  3  FtsH_ext  FtsH Extracellular


Domain annotation for each model (and alignments):
>> HSCB_C  HSCB C-terminal oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.1   0.00024       2.2      27      62 ..     112     147 ..     106     149 .. 0.91
   2 ?    3.2   0.0     0.014   1.3e+02      33      58 ..     290     318 ..     282     323 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00024
                 HHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHH CS
      HSCB_C  27 eleelkaeveerieeleaeleeafekkdleaaadll 62 
                 el+ +k+e++ +++el++++ ++fe ++le ++d++
  EFC37495.1 112 ELDVFKRELDDEVKELLQKCVKQFEGEELEHLKDAI 147
                 78999*******************888999999876 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.014
                 HHHHHHHHHHHHHHHHHH...HTT-HHHH CS
      HSCB_C  33 aeveerieeleaeleeaf...ekkdleaa 58 
                   ++++++e+ ++l++af   e++d+++ 
  EFC37495.1 290 PTLSQELKECAERLQTAFfviEESDYSKF 318
                 56889*************99888888775 PP

>> FtsH_ext  FtsH Extracellular
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0     0.048   4.3e+02      77      98 ..      23      44 ..      14      53 .. 0.82
   2 ?    8.0   0.0    0.0004       3.6      49     100 ..      70     127 ..      66     134 .. 0.83
   3 ?   -3.3   0.0       1.3   1.1e+04      58      74 ..     318     334 ..     308     344 .. 0.51

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.048
    FtsH_ext 77 tystptlgsvesleekLeealk 98
                ++  ++l++++s++++L++  +
  EFC37495.1 23 NVLLHSLPQNPSFTSRLVQYDY 44
                567899***********99766 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0004
    FtsH_ext  49 vqestis......alirrptgdgvsttkkgnstttystptlgsvesleekLeealksk 100
                 v+++++        l+ r +g+ +++ +k +  ++++++t+++ + + ++L++  k++
  EFC37495.1  70 VVDNSQDkyivgsGLLLRKNGKYFFMQNKASIGKVMFIFTILELDVFKRELDDEVKEL 127
                 4444444466677778899999******************************998875 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 1.3
    FtsH_ext  58 irrptgdgvsttkkgns 74 
                  r +t+ ++  +k+++ 
  EFC37495.1 318 FRLNTKFVDEEKKNKRE 334
                 33444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (359 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       723  (0.0403257); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.26s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 2286.16
//
Query:       EFC37496.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0012   19.4   0.0     0.0014   19.1   0.0    1.2  1  Metallophos  Calcineurin-like phosphoesterase


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0     8e-08    0.0014     128     203 ..      79     152 ..      20     153 .. 0.65

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 8e-08
                  THHHHHHHHHHHSCHHHHCCHHHHHHHHHHTTCSEEEEEESSESS.....CSSSCSCCHHHHH.HHHHHTTESEEEEESSSS CS
  Metallophos 128 lvsldklgslnleleapepgdewlkdlekrekadwvivlgHsply.....rgsgylfgdeale.dllkkygvdlvisGHtHv 203
                  l ++d+   ++ ++e     ++++++     + d++i+++Hsp+      +  gy  g  ++  +ll+ +++++ ++GH+H 
   EFC37496.1  79 LQNFDDKFFFKNDKEL----EKIFSK----IPEDVDILITHSPPKfildfNEFGYNRGCSQILaKLLDLHKLKIHLFGHIHS 152
                  3333333333333333....666666....899************888774444444444444699***************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       790  (0.0440627); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1351.28
//
Query:       EFC37497.1  [L=209]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-30  106.0   0.1      2e-30  105.5   0.1    1.2  1  Ras           Ras family
    3.9e-13   49.7   0.0      1e-12   48.3   0.0    1.6  2  Roc           Ras of Complex, Roc, domain of DAPkinase
    8.9e-11   41.5   0.0    1.3e-10   41.1   0.0    1.1  1  Arf           ADP-ribosylation factor family
      4e-06   26.8   0.1     0.0016   18.3   0.1    2.2  2  RsgA_GTPase   RsgA GTPase
     0.0001   21.6   0.4       0.32   10.1   0.0    2.1  2  G-alpha       G-protein alpha subunit
    0.00022   20.8   0.1    0.00027   20.6   0.1    1.2  1  GTP_EFTU      Elongation factor Tu GTP binding domain
     0.0031   16.9   0.9     0.0073   15.7   0.9    1.6  1  Gtr1_RagA     Gtr1/RagA G protein conserved region
     0.0089   15.6   1.4       0.88    9.1   0.2    3.1  3  FeoB_N        Ferrous iron transport protein B
  ------ inclusion threshold ------
      0.024   14.4   0.5       0.11   12.3   0.4    2.0  2  ATP_bind_1    Conserved hypothetical ATP binding protein
       0.04   14.2   0.1       0.11   12.8   0.0    1.7  2  DUF4375       Domain of unknown function (DUF4375)
      0.087   11.8   0.2       0.31   10.0   0.1    1.8  2  MeaB          Methylmalonyl Co-A mutase-associated GTPase Mea
      0.099   12.6   4.2       0.17   11.8   4.2    1.4  1  LMP           LMP repeated region
       0.18   11.8   2.1       0.52   10.3   1.2    2.1  2  MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
       0.43    9.9   3.1        0.3   10.4   0.5    2.0  2  AIG1          AIG1 family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  105.5   0.1   1.6e-33     2e-30       1     159 [.       2     171 ..       2     174 .. 0.86

  Alignments for each domain:
  == domain 1  score: 105.5 bits;  conditional E-value: 1.6e-33
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 ++vl+G ++vGK++++++f ++ F  ey++ i +d+y+k+  vd++++ ++i+DTA  e ++ ++e+y++ a+++++v d+t+r ++ +v++ v+++  
  EFC37497.1   2 RIVLLGRGGVGKSAITIQFCQHIFYPEYDPSI-EDSYRKTAIVDNTQLIFDILDTAYLEYYSPMKEQYMHYAHAFIVVCDLTDRPTLVEVNSAVNDLVL 99 
                 59******************************.***************************************************************988 PP

                 HST...TTSEEEEEEETTTGGG..G-SS-HHHHHHHH.......HHHTSEEEEEBTTTTCTHHHHHHHHHHH CS
         Ras 100 vae...envpivLvGnKvDlee..kravsteegeela.......kelglkfletSAktnenveeafeellre 159
                   +   +++piv   nK+Dl +  ++++ tee ++         + ++ k +e+SAk+++n++e+f++l+r+
  EFC37497.1 100 AQDrevNDMPIVFALNKIDLLNdsDKKLATEEFSSEIrkivnefSLTNWKIMECSAKQRQNIDEIFMDLARR 171
                 88778889************9888344444433222212222222345788*****************9986 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.3   0.0     8e-16     1e-12       1     120 []       2     119 ..       2     119 .. 0.83
   2 ?   -1.5   0.1       2.2   2.8e+03      37      70 ..     146     175 ..     125     201 .. 0.50

  Alignments for each domain:
  == domain 1  score: 48.3 bits;  conditional E-value: 8e-16
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE.......GHHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd.......srss 92 
                 ++vl+G +gvGK+ +  +f+++ f +++++ i  ++ ++ +     v+n    +++ ++i Dta  e ++ +++ y++ a+++i+v+d        + +
  EFC37497.1   2 RIVLLGRGGVGKSAITIQFCQHIFYPEYDPSIEDSYRKTAI-----VDN----TQLIFDILDTAYLEYYSPMKEQYMHYAHAFIVVCDltdrptlVEVN 91 
                 69*******************************99976654.....333....4689******************************965432222223 PP

                 HCHHHHHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  93 enlkeWlkelkkvagkspvilvgnkiDl 120
                 + +++ +   ++++++ p+++  nkiDl
  EFC37497.1  92 SAVNDLVLAQDREVNDMPIVFALNKIDL 119
                 55677777777888899*********95 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 2.2
                 EEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTT CS
         Roc  37 ltkevtkikgvendkkvkkvklniWDtaGqerfr 70 
                 +++++++++    + + +++   + D+a   +++
  EFC37497.1 146 TNWKIMECSA---K-QRQNIDEIFMDLARRRQYY 175
                 3333332222...2.2223333344555444444 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.1   0.0   9.8e-14   1.3e-10      15     172 ..       1     169 [.       1     171 [. 0.81

  Alignments for each domain:
  == domain 1  score: 41.1 bits;  conditional E-value: 9.8e-14
                 EEEEEEESTTSSHHHHHHHHHHSSCE.ECSSSSSEEEEEEEE...TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHHC. CS
         Arf  15 lrilllGLDnaGKtTilkklkleelv.ttvPTigfnveelei...knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLkall. 108
                 +ri+llG  + GK+ i  ++ ++ +  +  P i    ++ +i    +l f + D    e   p+ ++Y++  +a i v D +dr  l e ++ ++ l+ 
  EFC37497.1   1 MRIVLLGRGGVGKSAITIQFCQHIFYpEYDPSIEDSYRKTAIvdnTQLIFDILDTAYLEYYSPMKEQYMHYAHAFIVVCDLTDRPTLVEVNSAVNDLVl 99 
                 79***************999988776268999998888777632256667777777778888999*****************************98753 PP

                 .TSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSS......SSSSEEEEEEBTTTTBTHHHHHHHHH CS
         Arf 109 .eeeelkevallvlaNKqDlpealseeelrellgleelk......gkrkleiqkcsavkgeglkeglewls 172
                  +++e+++++++   NK+Dl ++ +++  +e+ + e ++      + ++++i++csa ++++++e +  l+
  EFC37497.1 100 aQDREVNDMPIVFALNKIDLLNDSDKKLATEEFSSE-IRkivnefSLTNWKIMECSAKQRQNIDEIFMDLA 169
                 3778999*************9998877666665433.22233566788****************9987765 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0    0.0055       7.1     102     116 ..       3      17 ..       1      30 [. 0.86
   2 !   18.3   0.1   1.3e-06    0.0016      37      99 ..      95     170 ..      60     175 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0055
                  EEEECSTTSSHHHHH CS
  RsgA_GTPase 102 svlvGqSGvGKStLi 116
                  +vl+G  GvGKS++ 
   EFC37497.1   3 IVLLGRGGVGKSAIT 17 
                  69**********986 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 1.3e-06
                  HHHHHHHHTT-...EEEEEEE-GGG--HHH..........HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTT CS
  RsgA_GTPase  37 rfLvlaeekgi...epvivlnKiDlleeee..........eleelkeelealgyevllvsaktkegleelkellkd 99 
                    Lvla+++++   ++v +lnKiDll++++          e++++ +e++ ++ +++ +sak++++++e+   l+ 
   EFC37497.1  95 NDLVLAQDREVndmPIVFALNKIDLLNDSDkklateefssEIRKIVNEFSLTNWKIMECSAKQRQNIDEIFMDLAR 170
                  4466665554432278899*********9999*999999999999999999******************9888876 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   0.00025      0.32      24      85 ..       1      60 [.       1     103 [. 0.76
   2 !    9.5   0.9   0.00039       0.5     263     319 ..     101     168 ..      97     199 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00025
                EEEEEEESTTSSHHHHHHHHH.HHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT... CS
     G-alpha 24 vkllllGqseSGKsTilkqlk.llykkgfseeelatwraviqlnivrsiktilealeslesel 85
                ++++llG ++ GKs i  q+   ++ ++++ +   ++r+   + iv++ ++i+++l++   e 
  EFC37497.1  1 MRIVLLGRGGVGKSAITIQFCqHIFYPEYDPSIEDSYRK---TAIVDNTQLIFDILDTAYLEY 60
                689*************99996566668888773344655...889999999999998854444 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00039
                 C-GGGTTSEEEEEEE-HHHHH...HHCCCS....-GGGCCTT--....H.CCHHHHHHHHHHHHHHCC CS
     G-alpha 263 nnkllkntpiiLflnKlDile...eKlkkg....klskyfpsye....grkndlesvlkylrnkFeei 319
                 + ++++++pi++ lnK+D+l+   +Kl ++    +++k++ +++    +  +   +  +++ + F+++
  EFC37497.1 101 QDREVNDMPIVFALNKIDLLNdsdKKLATEefssEIRKIVNEFSltnwKIMECSAKQRQNIDEIFMDL 168
                 668899**************744468855512234445556665544422222333334444444444 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.1   2.1e-07   0.00027      67     186 ..      45     166 ..      13     191 .. 0.68

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 2.1e-07
                 CSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB.....STHHHHHHHHHHHHTTTE...EEEEEESCGST.HHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  67 tkkylinliDtPGHvdFskevirglrvlDgavlvvdaveG.....vepqteevlrlalkegvp...iivfiNKmDrl.kaelkeiveevkqklsrkeek 156
                  ++  + ++Dt   + +s   ++ +  ++  ++v+d ++      v++  +  l la++++v+   i++++NK+D l +++ k   ee ++++    + 
  EFC37497.1  45 NTQLIFDILDTAYLEYYSPMKEQYMHYAHAFIVVCDLTDRptlveVNSAVN-DLVLAQDREVNdmpIVFALNKIDLLnDSDKKLATEEFSSEI---RKI 139
                 555566777777666677777777888899999999998777733333333.344555555555559999*******8777777778888777...333 PP

                 HHHHHHTTTTTEEEEEEBTTTTBTHHHHHH CS
    GTP_EFTU 157 lekygekgekevpvvfgSalkgegvktlle 186
                 ++++     ++ +++ +Sa++ +++++++ 
  EFC37497.1 140 VNEFSL---TNWKIMECSAKQRQNIDEIFM 166
                 333333...3689**********9997543 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.9   5.7e-06    0.0073       2     158 ..       3     154 ..       2     160 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 5.7e-06
   Gtr1_RagA   2 vLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletlk 99 
                 ++L+G++g GK+++  i F + +        +  + +k+ +  + +l ++++D     a++e  +s  ke+ ++   + i V D ++r  l e  +  +
  EFC37497.1   3 IVLLGRGGVGKSAIT-IQFCQHIFYPEYDPSIEDSYRKTAIVDNTQLIFDILDT----AYLEY-YSPMKEQYMHYAHAFIVVCDLTDRPtLVEVNSAVN 95 
                 789999999999985.33443333333333444455666666677778999985....45555.588899999*************9952555555556 PP

   Gtr1_RagA 100 eilealrqyspeakvfvlihKmDliqedereeifeerkeeireeieklekeeiqffaTS 158
                 +++ a  +  +++ +   ++K+Dl++++ ++ + ee ++eir+ +++++ ++ +++  S
  EFC37497.1  96 DLVLAQDREVNDMPIVFALNKIDLLNDSDKKLATEEFSSEIRKIVNEFSLTNWKIMECS 154
                 6666666666777888889*************************999988877766655 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.46   5.9e+02       2      18 ..       2      18 ..       1      23 [. 0.82
   2 ?    3.8   0.1      0.03        38      65     117 ..      33      84 ..      26     100 .. 0.83
   3 !    9.1   0.2   0.00069      0.88      95     138 ..      97     140 ..      86     168 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.46
                EEEEEESTTSSHHHHHH CS
      FeoB_N  2 tvalvGnpnvGkttlfn 18
                +++l+G   vGk+++  
  EFC37497.1  2 RIVLLGRGGVGKSAITI 18
                799**********9865 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.03
                 HHHHHHHHHHHCTSSSEEEEEEEGGGHHHHHHHHHHHHHTTSSEEEEEETHHH CS
      FeoB_N  65 eeekvardflleeepdvvvnvvdatnlernLyLtlqllelgvpvvlalnmide 117
                 +e++  ++ ++ ++++++ +++d++ le    +  q +   + ++++ +++d 
  EFC37497.1  33 IEDSYRKTAIV-DNTQLIFDILDTAYLEYYSPMKEQYMHYAHAFIVVCDLTDR 84 
                 55555555555.7789******************************9999986 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00069
                 HHHHHHHHHTTSSEEEEEETHHHHHHTTEEE-HHHHHHHHTS-E CS
      FeoB_N  95 LyLtlqllelgvpvvlalnmideaekkgieidlkkLsekLgvpv 138
                 L+L  +    ++p+v aln+id ++++  ++ ++++s+++   v
  EFC37497.1  97 LVLAQDREVNDMPIVFALNKIDLLNDSDKKLATEEFSSEIRKIV 140
                 4444443334589********************99998875333 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.58   7.5e+02       2      20 ..       6      24 ..       5      32 .. 0.85
   2 ?   12.3   0.4   8.5e-05      0.11     125     211 ..      77     168 ..      61     199 .. 0.63

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.58
  ATP_bind_1  2 vGpaGsGKttfvgalseil 20
                +G  G+GK+ ++ ++ +++
  EFC37497.1  6 LGRGGVGKSAITIQFCQHI 24
                6889******999988886 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 8.5e-05
  ATP_bind_1 125 vvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek......lekeleffedvealslllekee....ekykklaeaiaelleef 211
                 vv  L D ++l ++ + ++ l++a    +  ++P v +lnk+Dll+++      +e+  e  + v+++sl+    +    e  +k+ ++i e++++ 
  EFC37497.1  77 VVCDLTDRPTLVEVNSAVNDLVLAQDREV-NDMPIVFALNKIDLLNDSdkklatEEFSSEIRKIVNEFSLT----NwkimECSAKQRQNIDEIFMDL 168
                 55557777777777777777555555554.58*************97764232222222333333333333....2444455556666666555554 PP

>> DUF4375  Domain of unknown function (DUF4375)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   8.5e-05      0.11      52     115 ..      13      74 ..       6      76 .. 0.86
   2 ?   -1.8   0.1       2.9   3.7e+03      72      72 ..     157     157 ..     118     185 .. 0.58

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 8.5e-05
                 HHHHHHHHHHH.HHHHHHHHHHHHHHTT-HHHHHHH.-GGGHHHHHHHHHHHHHHHHHHHHHHHC CS
     DUF4375  52 elakllekakk.lykkgkeelereerdeelealyeeeeeefdelDdefyeyeeeltellaeYvde 115
                 + a  ++ +   +y+++ +++e   r++   a+ ++++  fd lD+++ ey   ++e+ ++Y+++
  EFC37497.1  13 KSAITIQFCQHiFYPEYDPSIEDSYRKT---AIVDNTQLIFDILDTAYLEYYSPMKEQYMHYAHA 74 
                 666677777787899***********98...788888*************************875 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2.9
                 H CS
     DUF4375  72 e 72 
                 +
  EFC37497.1 157 Q 157
                 2 PP

>> MeaB  Methylmalonyl Co-A mutase-associated GTPase MeaB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.36   4.7e+02      31      51 ..       2      22 ..       1      26 [. 0.76
   2 ?   10.0   0.1   0.00024      0.31     141     231 ..      80     174 ..      74     202 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.36
                EEEEEE-TTSSHHHHHHHHHH CS
        MeaB 31 vvGltGvPGaGkstlvealgl 51
                ++ l G  G+Gks ++ ++ +
  EFC37497.1  2 RIVLLGRGGVGKSAITIQFCQ 22
                567789999999998877765 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00024
                 TT-SEEEEEEESSTTTT.TTT--CCCHHH-SEEEEE---...HHHHHHHHHHHHHHHHHCSTTBTTB--EEEEEBCCCTBSHHHHHHHHHHHHHH CS
        MeaB 141 evvdtfvvlllpeaGDe.lqgikkGileiaDiivvnkaD...kkeaekaarelraaleleeekekeWrpkvlktsavegeGidelvdaieehrev 231
                 +++d   ++ +++a ++ + +  + + ++  ++++nk D    ++ + a++e+++ +++  ++ +  + k++++sa++ + ide++  + + r++
  EFC37497.1  80 DLTDRPTLVEVNSAVNDlVLAQDREVNDMPIVFALNKIDllnDSDKKLATEEFSSEIRKIVNEFSLTNWKIMECSAKQRQNIDEIFMDLARRRQY 174
                 55565566666555444144556667777778899****8655556677888888888888887777779***************9988776665 PP

>> LMP  LMP repeated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   4.2   0.00014      0.17      23     117 ..     101     203 ..      83     207 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00014
         LMP  23 LekeiqkanqalnsnntasmqsakssLdak..vteitkkLekFnkdkeakFkeLeqtRkdieeFl.kdvknnpnYa.....elvkdLtskkdsknsvtk 113
                  ++e+++    ++ n ++ ++  ++ L +    +ei+k++++F     +  +   + R++i+e   +  ++ ++Y      +l++++t ++++k+s+++
  EFC37497.1 101 QDREVNDMPIVFALNKIDLLNDSDKKLATEefSSEIRKIVNEFSLTNWKIMECSAKQRQNIDEIFmDLARRRQYYDivddfTLLQNITLENSQKKSISE 199
                 5778888888889999999998888886542258**********99888888889********7736666666664444446778889999******98 PP

         LMP 114 ssnk 117
                  s  
  EFC37497.1 200 HSRH 203
                 7754 PP

>> MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   1.2   0.00041      0.52      42      96 ..      94     164 ..      62     171 .. 0.73
   2 ?    4.3   0.2     0.031        40      18      56 ..     134     175 ..     123     201 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00041
  MMR_HSR1_Xtn  42 vDdlidviegnrvYipclyvlNKiDlisleeldelare................pnsvviSaekelnldeL 96 
                   v+dl+ +   + + +p +++lNKiDl+++++ +  ++e                 +++ +Sa+++ n+de+
    EFC37497.1  94 VNDLVLAQDREVNDMPIVFALNKIDLLNDSDKKLATEEfsseirkivnefsltnWKIMECSAKQRQNIDEI 164
                   6666666666677799**********877776665555555666667777776447777999999999987 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.031
  MMR_HSR1_Xtn  18 etvkkilkeykihnaevl...iredvtvDdlidviegnrvYi 56 
                   ++++ki++e+ ++n +++    +++ ++D++   ++  r+Y 
    EFC37497.1 134 SEIRKIVNEFSLTNWKIMecsAKQRQNIDEIFMDLARRRQYY 175
                   678899999888888876322455666777666666667775 PP

>> AIG1  AIG1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.5   0.00024       0.3       2      15 ..       2      15 ..       1      56 [. 0.94
   2 ?   -0.1   0.1      0.38   4.8e+02      85     153 ..      73     143 ..      42     176 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00024
                EEEEESSTTSSHHH CS
        AIG1  2 tivlvGktgnGkSa 15
                +ivl+G+ g+GkSa
  EFC37497.1  2 RIVLLGRGGVGKSA 15
                8************9 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.38
                 SEEEEEEETT.B-SHHH.HHHHHHHHHHHCGGGGGGEEEEEEEGGGGTTCCHHHHHHHHH-HHHHHHHHHT CS
        AIG1  85 halllvlslg.rfteed.ekalktlkelFGekilkylivvftrkddleddsledylsksspeaLkevlkec 153
                 ha+++v +l+ r t  + ++a++ l  + + ++ +  iv   +k dl +ds ++  +++    ++++++e+
  EFC37497.1  73 HAFIVVCDLTdRPTLVEvNSAVNDLVLAQDREVNDMPIVFALNKIDLLNDSDKKLATEEFSSEIRKIVNEF 143
                 66666666665555433145666666666666666666666666565555544444444444555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       970  (0.0541023); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1299.70
//
Query:       EFC37498.1  [L=553]
Description: hypothetical protein NAEGRDRAFT_74705 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.4e-33  112.7  16.7    4.3e-06   27.2   0.8    8.1  8  Sel1        Sel1 repeat
     0.0014   18.5   0.1     0.0025   17.7   0.1    1.4  1  F-box-like  F-box-like
     0.0034   17.2   0.0     0.0074   16.1   0.0    1.6  1  F-box       F-box domain
  ------ inclusion threshold ------
       0.18   11.6  22.2        0.2   11.5  14.4    2.6  2  ZZ          Zinc finger, ZZ type
       0.26   11.8   7.4        0.2   12.1   3.8    2.7  3  LRR_4       Leucine Rich repeats (2 copies)
        3.7    8.5   4.9        8.6    7.4   0.0    3.9  5  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.5    0.0091        27      10      38 .]     191     220 ..     187     220 .. 0.88
   2 !   13.6   0.1   2.8e-05     0.083      14      35 ..     226     248 ..     225     251 .. 0.84
   3 !    8.5   0.1    0.0011       3.4       3      38 .]     254     283 ..     252     283 .. 0.77
   4 !   27.2   0.8   1.4e-09   4.3e-06       5      38 .]     288     319 ..     285     319 .. 0.92
   5 !   10.0   0.0   0.00039       1.2       8      38 .]     327     355 ..     322     355 .. 0.91
   6 !   25.0   0.0   7.4e-09   2.2e-05       1      37 [.     356     390 ..     356     391 .. 0.91
   7 !   27.0   0.0   1.7e-09   5.2e-06       2      38 .]     393     427 ..     392     427 .. 0.94
   8 ?   -1.7   0.0       1.8   5.3e+03       8      30 ..     435     456 ..     435     458 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0091
        Sel1  10 fylylnGlgvpkD.pekAiewyekAAeqGd 38 
                 +y++l+G  +  D  e+ +e+++k+A++G+
  EFC37498.1 191 WYYFLAGYFENVDcAELSEEYLRKSANLGY 220
                 69999999888898888***********96 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 2.8e-05
        Sel1  14 lnGlg.vpkDpekAiewyekAAe 35 
                 ++Gl  v+ ++e+A+ w++kAAe
  EFC37498.1 226 EYGLLkVKDNQEEALIWLKKAAE 248
                 6899756669************8 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0011
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 A+  L   +  l+G       e+ ++w+  AAeqG+
  EFC37498.1 254 AQIYLS--E--LYGN--RGENELSFKWLLTAAEQGN 283
                 677777..7..6665..445899************7 PP

  == domain 4  score: 27.2 bits;  conditional E-value: 1.4e-09
        Sel1   5 yrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 y+LG   +y +G+gv+ D+ekA++w+ kA e+Gd
  EFC37498.1 288 YNLG--FYYREGTGVKMDYEKALHWFLKAEEHGD 319
                 9***..555******99***************97 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00039
        Sel1   8 GmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 G   +y  G+gv+ ++ek  e+  +AA++Gd
  EFC37498.1 327 G--HMYGIGQGVEVNEEKSTELTLRAAMRGD 355
                 7..7889999*******************97 PP

  == domain 6  score: 25.0 bits;  conditional E-value: 7.4e-09
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 ++++y+LG    y++G+g+++D ek + w+  AA+++
  EFC37498.1 356 SSSQYNLG--VKYYHGTGTERDLEKSFNWFLNAANAD 390
                 68******..5569********************876 PP

  == domain 7  score: 27.0 bits;  conditional E-value: 1.7e-09
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  A+ r+G  +++  G gv++D+++A+ w++ A++qGd
  EFC37498.1 393 LAQKRVG--CMFSSGEGVEQDIDRAMFWLKEACDQGD 427
                 6999***..888************************7 PP

  == domain 8  score: -1.7 bits;  conditional E-value: 1.8
        Sel1   8 GmfylylnGl.gvpkDpekAiewy 30 
                 G   ++++Gl + + D ek ++++
  EFC37498.1 435 G--IMHYFGLhDCELDLEKSRQFL 456
                 5..6899**987998999888766 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.1   8.2e-07    0.0025       2      40 ..      38      76 ..      37      82 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 8.2e-07
  F-box-like  2 srLPdEiLlqIFsyLpps.dLlrlalVCrrWrrvaldtpl 40
                + LPdE++  I+ ++p++  +++ ++ ++ W++++++  +
  EFC37498.1 38 QELPDELIKLILNFIPDQyIIASTCRISKEWYEICSNG-S 76
                67*************777478889**********9876.5 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   2.5e-06    0.0074       2      39 ..      36      74 ..      35      81 .. 0.93

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 2.5e-06
                HHHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTT CS
       F-box  2 tlsrLPsevlrhILerLplsd.llalrrVSkgwrilids 39
                ++ +LP+e+++ IL + p  + + +  r Sk w+ ++ +
  EFC37498.1 36 KFQELPDELIKLILNFIPDQYiIASTCRISKEWYEICSN 74
                799********************************9975 PP

>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  14.4   6.7e-05       0.2       6      37 ..     476     508 ..     472     511 .. 0.88
   2 ?    5.1   1.1    0.0065        20       3      15 ..     508     520 ..     506     525 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 6.7e-05
                 E-TTT-S..EESSEEEESSSS.S-EE-HHHHHH CS
          ZZ   6 tCdgCseapligvRyhclrcs.dYDLCqsCfst 37 
                  C++C    ++g+ y c+  s d+DLCq+C+  
  EFC37498.1 476 CCNECFVEDFNGFNYECANLScDFDLCQRCYEN 508
                 5****************98655********975 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0065
                 S-EE-TTT-S..E CS
          ZZ   3 kkytCdgCseapl 15 
                 ++++C++C++  +
  EFC37498.1 508 NGAKCNKCGNSKF 520
                 6899*****9766 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       2.7     8e+03      26      42 ..      25      40 ..      24      49 .. 0.58
   2 ?    8.2   1.2    0.0011       3.4      12      36 ..      87     115 ..      80     119 .. 0.67
   3 ?   12.1   3.8   6.8e-05       0.2       2      33 ..     104     140 ..     103     149 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.7
                -EEE-.-S-----GGGG CS
       LRR_4 26 keLdLsgNnlitdldeL 42
                ke+ Ls+N + t++ eL
  EFC37498.1 25 KEIKLSSNIK-TKFQEL 40
                5566666622.344444 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0011
                 ---E-S-..HH...H-TT--EEE-.-S--- CS
       LRR_4  12 qltdipl..le...klpnLkeLdLsgNnli 36 
                 +++ ++l  l     + nL +L+L +Nn++
  EFC37498.1  87 RIKRLDLvkLCdcpMMRNLVYLNL-NNNQL 115
                 566666644114546999999999.66676 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 6.8e-05
                 S--EEE--SS-.....--E-S-HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNq.....ltdiplleklpnLkeLdLsgN 33 
                 nL +L+L+nNq     +  i++ e l+nL+eL L+  
  EFC37498.1 104 NLVYLNLNNNQlpqryVAMIGGSEYLTNLEELELNKS 140
                 99*********88888777777778*********554 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       3.8   1.1e+04       3      17 ..      25      41 ..      24      47 .. 0.66
   2 ?   -2.9   0.0         6   1.8e+04       2      10 ..      88      99 ..      87     100 .. 0.62
   3 ?    7.4   0.0    0.0029       8.6       1      16 [.     104     119 ..     104     125 .. 0.84
   4 ?    0.0   0.0      0.73   2.2e+03       1      12 [.     131     142 ..     131     161 .. 0.80
   5 ?   -2.3   0.1       4.1   1.2e+04      17      17 ..     465     465 ..     446     482 .. 0.47

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 3.8
       LRR_1  3 rhLdLsnnpl..lglpp 17
                +++ Ls+n+   ++ +p
  EFC37498.1 25 KEIKLSSNIKtkFQELP 41
                67889999864445555 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 6
       LRR_1  2 LrhLdL...snn 10
                 ++LdL   +++
  EFC37498.1 88 IKRLDLvklCDC 99
                589997444666 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0029
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 nL +L+L+nn+l++  
  EFC37498.1 104 NLVYLNLNNNQLPQRY 119
                 899********98876 PP

  == domain 4  score: 0.0 bits;  conditional E-value: 0.73
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L L+   l
  EFC37498.1 131 NLEELELNKSKL 142
                 8******87766 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 4.1
       LRR_1  17 p 17 
                 +
  EFC37498.1 465 D 465
                 2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (553 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       699  (0.0389871); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.55
# Mc/sec: 3046.34
//
Query:       EFC37499.1  [L=2003]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.9e-15   54.8 151.3    0.00029   21.1   5.6   10.5 10  EGF_2     EGF-like domain
  ------ inclusion threshold ------
      0.053   13.5   3.1       0.13   12.2   3.1    1.6  1  Jacalin   Jacalin-like lectin domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   2.2   0.00026       2.3      21      32 .]     651     662 ..     641     662 .. 0.82
   2 !   12.4   7.8   1.8e-05      0.16       5      32 .]     676     702 ..     672     702 .. 0.90
   3 !    9.9   7.8    0.0001      0.91       7      32 .]     719     741 ..     708     741 .. 0.84
   4 !    7.8  10.2   0.00049       4.4       4      32 .]     753     783 ..     751     783 .. 0.83
   5 !   21.1   5.6   3.2e-08   0.00029       5      32 .]     796     822 ..     793     822 .. 0.92
   6 !   13.0   7.2   1.1e-05       0.1       4      32 .]     834     861 ..     831     861 .. 0.88
   7 !   13.4  13.6   8.3e-06     0.075       5      32 .]     874     900 ..     866     900 .. 0.89
   8 !   13.2  11.6     1e-05     0.091       5      32 .]     913     939 ..     905     939 .. 0.87
   9 !   10.5  14.6   6.9e-05      0.61       5      32 .]     952     978 ..     944     978 .. 0.87
  10 ?   -0.3   0.6      0.16   1.5e+03      23      32 .]     981     990 ..     980     990 .. 0.93

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00026
       EGF_2  21 CdCdsgyqGktC 32 
                 CdC+sg+ G tC
  EFC37499.1 651 CDCKSGFEGSTC 662
                 ************ PP

  == domain 2  score: 12.4 bits;  conditional E-value: 1.8e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g G+C  ++  C C+ gy+G  C
  EFC37499.1 676 GVVCSGKGSCSGPN-SCACNLGYSGHAC 702
                 568********888.7*********999 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.0001
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  Cg  GtC +    CdC++g++G  C
  EFC37499.1 719 LCG-TGTCKSD--LCDCKPGFYGERC 741
                 575.7***944..5***********9 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.00049
       EGF_2   4 s.deiCgghGtCvnqcGqCdC..dsgyqGktC 32 
                 + + +C+ +G+C +++ +C+C   ++y G +C
  EFC37499.1 753 NtSYACSANGQCQSPN-NCQCydYTKYGGLQC 783
                 55689********999.8***87788878777 PP

  == domain 5  score: 21.1 bits;  conditional E-value: 3.2e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C ghG+C +++ +C C+++y G +C
  EFC37499.1 796 SDVCTGHGICTAPE-KCACEPNYLGQYC 822
                 678***********.************* PP

  == domain 6  score: 13.0 bits;  conditional E-value: 1.1e-05
       EGF_2   4 sdeiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                 s++ C+ +G+C+  + +qC+C   y+G+ C
  EFC37499.1 834 SSNVCNTRGKCI--GiNQCKCTLPYYGNEC 861
                 4789********..556************9 PP

  == domain 7  score: 13.4 bits;  conditional E-value: 8.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hG+C +++ +C C++gy+ ++C
  EFC37499.1 874 NNVCSSHGQCGSPN-NCTCQAGYFSNDC 900
                 899*******8899.8************ PP

  == domain 8  score: 13.2 bits;  conditional E-value: 1e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+GtC +++ +C+C  g++G  C
  EFC37499.1 913 SSVCSGRGTCQSPN-NCSCVEGHSGQVC 939
                 789********999.8*********988 PP

  == domain 9  score: 10.5 bits;  conditional E-value: 6.9e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C++++ +C+C+ ++ G +C
  EFC37499.1 952 SSVCSGNGNCISSN-NCQCKYNFNGTNC 978
                 789********888.8***********9 PP

  == domain 10  score: -0.3 bits;  conditional E-value: 0.16
       EGF_2  23 CdsgyqGktC 32 
                 C ++y+Gk C
  EFC37499.1 981 CANNYFGKRC 990
                 999******* PP

>> Jacalin  Jacalin-like lectin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   3.1   1.4e-05      0.13       5     127 ..     520     636 ..     516     640 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.4e-05
                 S-S.S-CEECEEEEEEESSSEEEEEEEEEETTSEE-EEEEEEEETTBSEEEEEETTT--EEEEEEEEEEESSSEEEEEEEEEEETTS-EEEEEC.--SE CS
     Jacalin   5 Ddg.eydgvrkvyvgqgedgiayikfeYvkaggkvegdehGkkgllgteefeidypdEyitsVegtydkvsvesevitsLtfkTnkgrtselfgtksgt 102
                 D++ ++d+  k +  +ge  ++ i f+Y  ++    g + G+  +  t++  i +pdEyit++e  +d   +  + + ++++kT  +   ++++++s +
  EFC37499.1 520 DHSfSTDQKVKSIACYGEGTVKGIVFNYFVGE----GFKAGTTEG-TTKT-IIFDPDEYITELEMSVDR-GTFITNVGYIRIKTDRQ-QFTFGQKRSSS 610
                 55667788888899999999999999999954....466666655.3444.5555*************8.555788999*******9.55588877777 PP

                 EEEEE-.SSEEEEEEEEEESSSEEEE CS
     Jacalin 103 kfslee.kgkkivGFhGragnllnal 127
                 + +    ++k ++    ++g+ ++++
  EFC37499.1 611 NYNYILdNDKTVIAWSIKSGTHVDSI 636
                 77766658888888888888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2003 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       826  (0.0460706); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.16u 0.35s 00:00:01.50 Elapsed: 00:00:00.61
# Mc/sec: 9884.55
//
Query:       EFC37500.1  [L=511]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.051   13.8   0.4       0.19   11.9   0.4    2.0  1  DASH_Dad1  DASH complex subunit Dad1
       0.76   10.0   5.8       0.13   12.4   1.7    1.9  2  Zn_clus    Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> DASH_Dad1  DASH complex subunit Dad1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.4   2.1e-05      0.19      11      47 ..     378     414 ..     373     424 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.1e-05
   DASH_Dad1  11 qeIaesmeevlnnlnaLNRsLEeviavgkeFesVaaL 47 
                  e  e+  ev+     LNR LE++ +++k +  + ++
  EFC37500.1 378 NEMFENSTEVVDYYSVLNRDLETLKQLSKRYRYITTI 414
                 68889999***********************999876 PP

>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.7   1.4e-05      0.13      19      39 ..       3      22 ..       1      24 [. 0.80
   2 ?   -3.3   0.1       1.2   1.1e+04      14      22 ..     477     485 ..     477     495 .. 0.59

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.4e-05
                S-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus 19 aCsnCkklnleCtfysesskr 39
                +Cs+C k+nleC  y+   +r
  EFC37500.1  3 KCSRCSKKNLECH-YDTVDRR 22
                6************.7765554 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.2
                 STSSSS-HH CS
     Zn_clus  14 dakkPaCsn 22 
                 d++kP C +
  EFC37500.1 477 DQEKPICDR 485
                 567777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (511 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1079  (0.0601818); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3031.94
//
Query:       EFC37501.1  [L=1363]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.8e-48  158.9   0.1     0.0018   18.2   0.0   12.2 12  NHL           NHL repeat
      5e-12   46.0  37.6    3.9e-05   23.9   8.6    3.6  3  EGF_2         EGF-like domain
    0.00017   21.7   0.4        1.2    9.0   0.0    4.0  4  Phytase-like  Esterase-like activity of phytase
     0.0013   18.3   7.3       0.27   10.8   1.5    4.6  4  SGL           SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
        1.4    9.3  31.8        2.7    8.4   4.8    3.7  3  EGF           EGF-like domain
        3.9    8.2  46.7       0.46   11.2   5.9    4.3  4  hEGF          Human growth factor-like EGF


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.0   0.00021      0.64       1      24 [.      45      68 ..      45      72 .. 0.84
   2 !   14.6   0.0   8.2e-06     0.024       4      27 ..     105     128 ..     103     129 .. 0.91
   3 !    9.6   0.0   0.00032      0.96       4      27 ..     161     184 ..     159     185 .. 0.89
   4 !    9.4   0.0   0.00037       1.1       6      26 ..     219     239 ..     218     241 .. 0.88
   5 !   18.1   0.0   6.6e-07     0.002       1      26 [.     270     295 ..     270     295 .. 0.96
   6 !    8.2   0.0   0.00093       2.8       2      26 ..     326     349 ..     325     349 .. 0.91
   7 !   16.7   0.0   1.9e-06    0.0055       1      27 [.     406     432 ..     406     433 .. 0.93
   8 !   18.2   0.0   6.2e-07    0.0018       1      26 [.     463     488 ..     463     488 .. 0.94
   9 !   13.3   0.0   2.2e-05     0.066       3      26 ..     520     543 ..     518     544 .. 0.89
  10 !    8.5   0.0   0.00073       2.2       6      26 ..     578     597 ..     573     599 .. 0.83
  11 !   14.7   0.0     8e-06     0.024       2      26 ..     629     653 ..     628     653 .. 0.95
  12 ?   -3.3   0.0       4.1   1.2e+04      14      26 ..     986    1000 ..     986    1001 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00021
                BSSEEEEEEETTTEEEEEECCCTE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhr 24
                f +P+ +a +snGdi+V+D   h 
  EFC37501.1 45 FKDPQKLARLSNGDILVSDALGHA 68
                779****************65555 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 8.2e-06
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P G+av+++++iy aDs+n+r+++
  EFC37501.1 105 PFGIAVSQTDEIYFADSGNNRIRK 128
                 669*******************97 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00032
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P +v+++++G++y+aD +n r+++
  EFC37501.1 161 PMDVSLSTSGELYIADMYNYRIRK 184
                 66999**************99986 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.00037
                 EEEEETTTEEEEEECCCTEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvq 26 
                 Gv v+snG++y++Ds n+ v+
  EFC37501.1 219 GVKVFSNGEVYISDSFNFKVR 239
                 899***********9887776 PP

  == domain 5  score: 18.1 bits;  conditional E-value: 6.6e-07
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +nyP++v  +++G++++aD++n+r++
  EFC37501.1 270 LNYPSDVFRFDTGELVIADTNNNRIR 295
                 79**********************96 PP

  == domain 6  score: 8.2 bits;  conditional E-value: 0.00093
                 SSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvq 26 
                 + P+G+++  ++ +++aD +n r++
  EFC37501.1 326 SLPTGLVLI-QNGLLIADAGNKRIR 349
                 67******8.999**********95 PP

  == domain 7  score: 16.7 bits;  conditional E-value: 1.9e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f +P+ +a +snGdi+V+D++ h++++
  EFC37501.1 406 FKDPQKIAKLSNGDIIVSDTGDHSIKK 432
                 678*********************987 PP

  == domain 8  score: 18.2 bits;  conditional E-value: 6.2e-07
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n P G+a++ n++iy+aD+ nhr++
  EFC37501.1 463 LNKPYGIAITANDEIYIADNLNHRIR 488
                 68899*******************96 PP

  == domain 9  score: 13.3 bits;  conditional E-value: 2.2e-05
                 SEEEEEEETTTEEEEEECCCTEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvq 26 
                  P +v+++ +Gd+y+aD+ n r++
  EFC37501.1 520 APMDVSLSASGDLYIADRDNYRIR 543
                 577999****************97 PP

  == domain 10  score: 8.5 bits;  conditional E-value: 0.00073
                 EEEEETTTEEEEEECCCTEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvq 26 
                 Gv v  nG++y++Ds+n  v+
  EFC37501.1 578 GVKVI-NGEVYISDSNNYKVR 597
                 67776.9**********9887 PP

  == domain 11  score: 14.7 bits;  conditional E-value: 8e-06
                 SSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvq 26 
                 n+P++va++++G+ ++aD+ n r++
  EFC37501.1 629 NHPTDVALLPSGEMIIADTDNYRIR 653
                 89*********************95 PP

  == domain 12  score: -3.3 bits;  conditional E-value: 4.1
                  EEEEEE..CCCTEEE CS
         NHL   14 diyVaD..senhrvq 26  
                  diyV +  +++ +vq
  EFC37501.1  986 DIYVGCegTNSYSVQ 1000
                  79**99766666666 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   8.6   1.3e-08   3.9e-05       5      32 .]     366     392 ..     361     392 .. 0.86
   2 !   18.0   7.8     9e-07    0.0027       6      32 .]     734     759 ..     729     759 .. 0.86
   3 !   15.8   5.3   4.5e-06     0.013       7      32 .]     774     797 ..     768     797 .. 0.90

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1.3e-08
       EGF_2   5 deiCgghGtCvnqcGq.CdCdsgyqGktC 32 
                 ++ C+g+G Cv  +++ C+C++g+ G+tC
  EFC37501.1 366 SNVCSGQGRCV--GNNiCQCNAGFEGPTC 392
                 578********..5334************ PP

  == domain 2  score: 18.0 bits;  conditional E-value: 9e-07
       EGF_2   6 eiCgghGtCvnqcGq..CdCdsgyqGktC 32 
                   C+g+G+C+   G+  C+C++g+ G  C
  EFC37501.1 734 YVCNGRGSCI---GKdlCQCNAGFNGTFC 759
                 57********...4555***********9 PP

  == domain 3  score: 15.8 bits;  conditional E-value: 4.5e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C g+G C   + +C C +g++G++C
  EFC37501.1 774 PCFGNGNCS--NDVCTCAPGFYGPYC 797
                 599*****9..768************ PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.0   0.00041       1.2      72     106 ..     107     141 ..      32     155 .. 0.80
   2 ?   -0.6   0.0      0.33   9.9e+02      75     101 ..     222     248 ..     219     255 .. 0.87
   3 ?   -0.2   0.0      0.26   7.7e+02      69     100 ..     408     440 ..     399     448 .. 0.83
   4 !    6.7   0.0    0.0021       6.2      37     103 ..     433     499 ..     420     513 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00041
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkllrelpl 106
                   giav++++++++++ g+++i+++d++G++++ + +
    EFC37501.1 107 GIAVSQTDEIYFADSGNNRIRKIDLTGTITTVVGT 141
                   9***************************9988765 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.33
  Phytase-like  75 vapdgtfwvssEggpfilefdadGkll 101
                   v ++g++++s+ ++  ++++d +G+++
    EFC37501.1 222 VFSNGEVYISDSFNFKVRKVDVNGTIT 248
                   5589********************986 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.26
  Phytase-like  69 DpEgiavapdgtfwvssEggpfilefdad.Gkl 100
                   Dp  ia  ++g+++vs+ g+++i +++ + G +
    EFC37501.1 408 DPQKIAKLSNGDIIVSDTGDHSIKKISYStGVI 440
                   777899999****************99875655 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0021
  Phytase-like  37 ldldadklgkveitevtplkdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdadGkllre 103
                   ++++++ +++++ t+v+ +  + g + + +   p gia+++++++++++  +++i+ +d +G++ + 
    EFC37501.1 433 ISYSTGVISRIAGTGVAGFSGDGGLASQAQLNKPYGIAITANDEIYIADNLNHRIRFVDVNGNISTV 499
                   44444566667777777777776555544444666***************************99765 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   1.5   9.2e-05      0.27      37     218 ..     100     305 ..      56     311 .. 0.67
   2 ?    2.3   0.0     0.036   1.1e+02     183     216 ..     455     496 ..     417     504 .. 0.66
   3 ?    4.1   0.1      0.01        30      30     161 ..     454     599 ..     439     669 .. 0.63
   4 ?    1.1   0.0     0.082   2.4e+02      16      78 ..     836     898 ..     832     918 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 9.2e-05
         SGL  37 ldtpesvGaiaprkdgrlvvasksglall..d........lasgeletladeee.dekpllrfNDgvvdpdGrlwfGtmgdeeakgeev.galyrldpd 123
                 + ++++ G+++  + +++++a +++ ++   d        + +g+ ++++d     +++ + + D+  +  G+l++ +m + + ++  + g+++ + ++
  EFC37501.1 100 ALVNKPFGIAVS-QTDEIYFADSGNNRIRkiDltgtittvVGTGDATPFIDGDLaTNCTINTPMDVSLSTSGELYIADMYNYRIRKVLTnGTIVTFAGS 197
                 666778888888.888888888887766644422332222344677777776325677888888***************76555554344********* PP

         SGL 124 gklervlddltipNGlawsp......dgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......ge.pDGlavDaeGnvwvAvwgggkvv 208
                 g+   + d+   +N+ +  +       +  +Y+ Ds ++k+ ++dv+ + +++    v  + +++        ++  D +  D +G++ +A  ++++++
  EFC37501.1 198 GQSGHTGDGGLATNAAMALAygvkvfSNGEVYISDSFNFKVRKVDVNGTITTVAGSGVApYSGDNILataanlNYpSDVFRFD-TGELVIADTNNNRIR 295
                 887777777766665544441222224556788*************9888887777766555554447777764424666665.577778888888888 PP

         SGL 209 rfdpdGklie 218
                  + p+G++i+
  EFC37501.1 296 LVMPNGTIIT 305
                 8888888775 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.036
         SGL 183 e........gepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                 +        ++p G+a++a++++++A   +++++ +d +G++
  EFC37501.1 455 GglasqaqlNKPYGIAITANDEIYIADNLNHRIRFVDVNGNI 496
                 344555555558899999999999999999999988888875 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.01
         SGL  30 atgketvldtpesvGaiaprkdgrlvvask..sglalldlasgeletlade...ee......dekpllrfNDgvvdpdGrlwfGtmgdeeakgeevgal 117
                 ++g  ++++++++ G+++  +++++++a +  ++++++d  +g+++t+a     ++         +l+ + D+  ++ G l++ + ++ + +  + g +
  EFC37501.1 454 DGGLASQAQLNKPYGIAIT-ANDEIYIADNlnHRIRFVD-VNGNISTVAGTsigFSgdsglaTAAKLNAPMDVSLSASGDLYIADRDNYRIRRVSSGVI 550
                 6666677777778888887.7777777765113344446.34466666655333114455555556777778888888888887777766666666666 PP

         SGL 118 yrldpdgk.....lervlddltipNGlawspdgktlYlaDsltrkiway 161
                   + ++g+        ++++ + + + +++  +  +Y+ Ds + k+ ++
  EFC37501.1 551 STFAGNGQsgysgDGGQATSAALSQAYGVKVINGEVYISDSNNYKVRKV 599
                 6665554323333333444445555555555555555555555555555 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.082
         SGL  16 wvDilgqrihrldpatgket.vldtpe.svGaiaprkdgrlvvasksglall.dlasgeletlade 78 
                 w+ i g +i +l   t+ +t ++ +p+  +++ ++   ++lv ++++g+al+ ++++g+++t ++ 
  EFC37501.1 836 WSQISGPTISNLATMTNLKTpTFIIPGkFNSLSFD---NGLVSGNTYGFALTaKITTGAYTTTVTT 898
                 66677777776665555433145666656666666...9*************99999999988765 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   4.8    0.0009       2.7       3      32 .]     366     391 ..     364     391 .. 0.82
   2 ?    7.1   4.4    0.0022       6.6       4      30 ..     732     756 ..     730     758 .. 0.86
   3 ?    5.3   6.8    0.0085        26       5      32 .]     774     796 ..     772     796 .. 0.92

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0009
                 STTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGkr 32 
                 +n Cs++G+C     g  +C+C  G+ G++
  EFC37501.1 366 SNVCSGQGRC---V-GNNICQCNAGFEGPT 391
                 466*******...3.4558********985 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0022
                 TT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytG 30 
                 +p  C+++G C     g   C+C  G+ G
  EFC37501.1 732 DPyvCNGRGSC----IGKDLCQCNAGFNG 756
                 6777*******....5788********99 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.0085
                 TSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 pCsngGtCvdtgrggytCiCpeGytGkr 32 
                 pC ++G C +       C+C++G+ G++
  EFC37501.1 774 PCFGNGNCSNDV-----CTCAPGFYGPY 796
                 8*******8888.....*********85 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   8.8    0.0007       2.1       1      22 []     369     387 ..     369     387 .. 0.94
   2 ?   11.2   5.9   0.00015      0.46       1      22 []     736     754 ..     736     754 .. 0.94
   3 ?   -2.7   0.8       3.6   1.1e+04       3      17 ..     755     765 ..     755     765 .. 0.73
   4 ?    6.2   8.6    0.0059        17       1      22 []     775     792 ..     775     792 .. 0.94

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0007
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C++ G+C+   g++ C+C+ G+
  EFC37501.1 369 CSGQGRCV---GNNICQCNAGF 387
                 9*******...778*******9 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00015
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn+ G+Ci   g   C+C+ G+
  EFC37501.1 736 CNGRGSCI---GKDLCQCNAGF 754
                 ********...679*******9 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3.6
                 TT-EES..-SS.-EE CS
        hEGF   3 ngGtCidgvggykCi 17 
                 ng++C    ++ +C+
  EFC37501.1 755 NGTFCA---NS-QCV 765
                 788888...77.775 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0059
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C ++G C    +  +C C+PG+
  EFC37501.1 775 CFGNGNCS---ND-VCTCAPGF 792
                 999*****...77.*******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1363 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       841  (0.0469072); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.85u 0.31s 00:00:01.15 Elapsed: 00:00:00.48
# Mc/sec: 8510.96
//
Query:       EFC37502.1  [L=402]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.5e-42  143.7   0.0    1.1e-41  142.8   0.0    1.5  1  APG6           Apg6 BARA domain
    7.4e-08   33.0  10.2    1.5e-07   32.0  10.2    1.6  1  APG6_N         Apg6 coiled-coil region
  ------ inclusion threshold ------
       0.11   12.8   0.1         11    6.4   0.1    2.6  2  GFA            Glutathione-dependent formaldehyde-activating 
        1.6    9.0   6.4          3    8.1   6.4    1.4  1  zf-C4H2        Zinc finger-containing protein
        2.5    8.7   6.4        1.2    9.8   2.2    2.2  2  FXMRP1_C_core  Fragile X-related 1 protein core C terminal
        6.6    4.7  11.9        8.7    4.3  11.9    1.1  1  DUF5401        Family of unknown function (DUF5401)


Domain annotation for each model (and alignments):
>> APG6  Apg6 BARA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.8   0.0   3.5e-45   1.1e-41       7     177 ..     235     400 ..     229     402 .] 0.89

  Alignments for each domain:
  == domain 1  score: 142.8 bits;  conditional E-value: 3.5e-45
        APG6   7 yndaFkIshdgkfgtInglrLGrlpsekvewsEinAAlGqtvlLLatiaekl.nlkfqeyklvplGstSkiekleekseevlelyssgelklgllfser 104
                 ++ +F+++ +g++gtInglr+Grl + +v+w+EinAA+G +vlLL+  a++l n+kf++yklvp +s+S i++le+ ++  ++l+ s++ +       +
  EFC37502.1 235 LAGMFHLWYEGSYGTINGLRMGRLRHDPVSWEEINAAWGLAVLLLDLTAQQLnNFKFTKYKLVPKASCSSIKELESGDK--YDLFFSSTRN------IQ 325
                 6779******************************************999998359****************88887766..******9885......57 PP

        APG6 105 kfDkamvafleclkqlaekvekedk..elelPYkikkdkdkigdlsiklqfneeeeWtkAlkllLtnlkwllawv 177
                 +f+++m++fl cl++l +++    +  ++     +k+d++ki+dls+  ++++e eWtkAlk+l++nlk++ + v
  EFC37502.1 326 SFNEGMKCFLFCLEELCQHIGIVVPgsSIGTRLIVKADEGKIQDLSMLYSVEREYEWTKALKYLIINLKFVQKNV 400
                 9*******************55444225666777899*********************************98765 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.0  10.2   5.1e-11   1.5e-07       2     119 ..     104     216 ..     104     229 .. 0.89

  Alignments for each domain:
  == domain 1  score: 32.0 bits;  conditional E-value: 5.1e-11
      APG6_N   2 lCeeCtdlLleeldkqleqaekerdaYeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeer 100
                 lC+ C+  L  +l +++eq+e e++ Y e lkk kk +++        ++  +e+++l++ee  l e+ + +++ r ++ + + +l+ e +  +e e++
  EFC37502.1 104 LCNTCMTDLFGGLSEEIEQLELECKLYDEKLKKSKKFDTN-G----MYKKYMKEMDELRNEELVLREQVNVIQNDRHRIGRNITSLQTEYNTQQESEKN 197
                 8**********************************99555.3....7899************************************************* PP

      APG6_N 101 fwreynelqlelleleeel 119
                 +w+ y ++ ++ + l ee 
  EFC37502.1 198 YWKIYFQFIHNNQFLAEEN 216
                 *****99766655444443 PP

>> GFA  Glutathione-dependent formaldehyde-activating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.1    0.0038        11      46      64 ..       3      22 ..       1      36 [. 0.73
   2 ?    3.8   0.0     0.025        73      43      69 ..      95     122 ..      79     149 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0038
         GFA 46 kvtrsfCpeCgsplyse.es 64
                 ++++ C +C s++y++ +s
  EFC37502.1  3 VKHKYPCTHCKSEVYFQpSS 22
                556799*********98522 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.025
         GFA  43 sgnkvtr.sfCpeCgsplyseesaapev 69 
                  ++ ++  + C++C++ l+   s++ e+
  EFC37502.1  95 LSTLINDlYLCNTCMTDLFGGLSEEIEQ 122
                 4555556699*********886665555 PP

>> zf-C4H2  Zinc finger-containing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   6.4     0.001         3      29      95 ..     142     208 ..     116     240 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.001
     zf-C4H2  29 eekcleeykkelelLeqEkmaHveeLrlIhaDinalEsvikeaeeekekslekakklyeeykklkee 95 
                 ++ + ++y ke+++L +E +   e++  I++D +++ + i + ++e + + e+ k+  + y +  ++
  EFC37502.1 142 TNGMYKKYMKEMDELRNEELVLREQVNVIQNDRHRIGRNITSLQTEYNTQQESEKNYWKIYFQFIHN 208
                 3456799*************************************99999999988888777766554 PP

>> FXMRP1_C_core  Fragile X-related 1 protein core C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.46   1.4e+03       7      23 ..     119     135 ..     117     143 .. 0.84
   2 ?    9.8   2.2   0.00039       1.2       4      51 ..     149     196 ..     148     200 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.46
  FXMRP1_C_core   7 EVeqLrlErLqIDeqLR 23 
                    E+eqL lE    De+L 
     EFC37502.1 119 EIEQLELECKLYDEKLK 135
                    9*******888888886 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00039
  FXMRP1_C_core   4 yLkEVeqLrlErLqIDeqLRqigggsrppesnrsdkekgystDeesge 51 
                    y+kE++ Lr E L + eq   i++ +    +n +  + +y+t +es++
     EFC37502.1 149 YMKEMDELRNEELVLREQVNVIQNDRHRIGRNITSLQTEYNTQQESEK 196
                    9*********************99988887888777778888866654 PP

>> DUF5401  Family of unknown function (DUF5401)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3  11.9    0.0029       8.7     432     526 ..     138     232 ..     117     236 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0029
     DUF5401 432 rqeelrrleeerarelervreeelerqqqverlrqqeeerkrkklelekekrekkeaeeerrkilekeleerkqalieeerkrkllekemeerqk 526
                 ++ + + + ++  +e++ +r+eel  ++qv++++++ +   r    l+ e + ++e e++  ki  + +++++    e++rk +l++ke + r+k
  EFC37502.1 138 KKFDTNGMYKKYMKEMDELRNEELVLREQVNVIQNDRHRIGRNITSLQTEYNTQQESEKNYWKIYFQFIHNNQFLAEENRRKSQLIDKEDKIRRK 232
                 555556666777899****************9999999888999999999999999999999999999988776666667788999999877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1306  (0.0728429); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 2430.95
//
Query:       EFC37503.1  [L=222]
Description: hypothetical protein NAEGRDRAFT_81889 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1216  (0.0678231); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1391.64
//
Query:       EFC37504.1  [L=1130]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0016   18.3  17.6     0.0016   18.3  17.6    4.6  5  Beta_helix  Right handed beta helix region


Domain annotation for each model (and alignments):
>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   1.9     0.052   9.3e+02      68     135 ..     148     229 ..      60     273 .. 0.67
   2 ?   -2.0   0.1      0.16   2.9e+03      99     121 ..     309     340 ..     276     356 .. 0.63
   3 ?   -2.7   0.0      0.26   4.6e+03      54      54 ..     459     459 ..     422     504 .. 0.50
   4 !   18.3  17.6   8.8e-08    0.0016      47     124 ..     633     712 ..     522     735 .. 0.76
   5 !   13.6   3.1   2.6e-06     0.046      24      90 ..     739     802 ..     718     836 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.052
                 -...........SEEE-TT--S--EEES-EEES-SS-SEE-TT-S--EEES-EEESTT.--SEE---TT...---EEES-EEE CS
  Beta_helix  68 n...........gggialfgasnnlienneitdnggsGiylnyssnntienNiidnna.gsGividdss...snvtvtnNtit 135
                             +g ++l+ a+ n+ +nn+   + +  + l+++  +t++ N ++  +   Gi i+  +   ++++ +++++t
  EFC37504.1 148 FlggdlskwyllDGTMKLQSAQLNIYQNNTKLVTVN-SFDLTNQLGVTFTFNLLTTWTaSRGILIYVDKlnyYEINLSGSSFT 229
                 044455555565677888888888888888888877.7888888888888888888887677777776666766655655554 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.16
                 T.....-S--EEES-EEESTT....--SEE-- CS
  Beta_helix  99 y.....ssnntienNiidnna....gsGivid 121
                 +     +sn ++  + ++n +    ++G+ ++
  EFC37504.1 309 TvdspsQSNFKVLQCKVYNGKlmhsRQGVTYH 340
                 23344455555555555555555555554444 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 0.26
                 T CS
  Beta_helix  54 s 54 
                 +
  EFC37504.1 459 V 459
                 1 PP

  == domain 4  score: 18.3 bits;  conditional E-value: 8.8e-08
                 -SEEE-TT.-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT CS
  Beta_helix  47 sGiyilgs.snntisnntisdnngggialfgasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdss 124
                 +Gi  +g+ +n +isn++   n+g+gi l+++sn l+++ e++ n ++G+++    ++ t++n + + n ++Gi + + +
  EFC37504.1 633 DGIVCSGGcTNLVISNCSAKYNGGSGISLSYSSNLLVDGGEMSQNFNNGVNFGgAVKDSTVQNTYTHRNINNGIWVGNAG 712
                 23333333588888888888888888888888888888888888888888888557888888888888888888877766 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 2.6e-06
                 -SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES- CS
  Beta_helix  24 yGiylrgssnvvienneiannsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdn 90 
                 + i+l +++n+++e+n ++++++ ++++ +   +++++n i ++    + +++a+ +++ nn +++ 
  EFC37504.1 739 DNIQLASADNITLESNILTQDGDQNMWMDKNGLVIFKRNIIIGGP---LGVNNAQSVVMFNNVFYNS 802
                 669999999999999999999999999999999999999999555...9999999999999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       548  (0.030565); expected 358.6 (0.02)
Passed bias filter:                      275  (0.0153383); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.26s 00:00:01.01 Elapsed: 00:00:00.45
# Mc/sec: 7516.46
//
Query:       EFC37505.1  [L=285]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.5e-22   76.9   0.5    1.9e-19   69.3   0.1    2.0  2  HSP70     Hsp70 protein


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.0   0.00015       2.6       2      36 ..      40      74 ..      39      81 .. 0.94
   2 !   69.3   0.1   1.1e-23   1.9e-19      94     256 ..     106     281 ..      97     284 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.00015
                EEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESE CS
       HSP70  2 iGiDLGttnsvvavmeggkievianeegnrttPsv 36
                iG+ +G+tn   avm +g+ e i++ +gn   Ps+
  EFC37505.1 40 IGLSIGNTNWRAAVMVNGSLEWIVDRNGNVDHPSF 74
                8****************************999985 PP

  == domain 2  score: 69.3 bits;  conditional E-value: 1.1e-23
                 TSBEEEEEEETTE...EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHH.HHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSS..... CS
       HSP70  94 ngkavveveaage...kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqR.qatkdAgkiAGLnvlRivNepTAaalaYGldkkd..... 183
                 ng ++ +v+  +    ++tpe+i + +L+ +ke a +yl++++t++ ++vPaYf+ +q  + +++A++   L ++R v +p  a la    +k      
  EFC37505.1 106 NGTVYCKVKLDDGiekEMTPEEIYSDILHDVKELAFQYLKRNITHIFLSVPAYFKQTQEdYIIRNAASKHNLTIVRSVRDPIMAVLAQDHFQKInnnyt 204
                 6666666665532334***************************************999725689***********************865444347888 PP

                 ....SCEEEEEEEEXSSXEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHH CS
       HSP70 184 ....kernvlvyDlGggtfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrl 256
                     +er+ lv+DlG  +    i++ + G +e++a     +lG e f  +l e +v+efkk++ ++ +++    q+l
  EFC37505.1 205 ndsnDERTFLVVDLGIRSLALNIVNDDFGFYEILASESYGQLGTERFHMKLRELFVKEFKKQHLLNEQSNILENQQL 281
                 88989*********************************************************999988887777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       754  (0.0420548); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 1850.16
//
Query:       EFC37506.1  [L=124]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.3e-10   37.7   0.2    7.8e-10   37.6   0.2    1.0  1  HSP70     Hsp70 protein
  ------ inclusion threshold ------
       0.17   10.9   0.0       0.23   10.4   0.0    1.2  1  PhoD      PhoD-like phosphatase


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   0.2   8.7e-14   7.8e-10     441     527 ..      24     110 ..       4     123 .. 0.78

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 8.7e-14
                 SBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEEEEETTTCCEEEEEEECCSSSBHHHH.HHHHHHHHHCHHHHHHHHHH CS
       HSP70 441 elvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvsakdketgkeeeitieaseglseeei.ekmvkdaeesaeedkkkkea 527
                   +++n +lg+ +l+gi+ +++G+ qieV+f++  + il+v+a+d +t++++e  i+ ++  s+ e  +k+++da +   e+k+ ++ 
  EFC37506.1  24 YEMEKNIQLGQLTLEGIELTKKGKAQIEVSFELSDSFILNVTATDLTTKVKSEKIISLEKLESNRELtNKLEQDATKD-GEEKEIRKL 110
                 4568899****************************************9999999999888866666515566665554.455555544 PP

>> PhoD  PhoD-like phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   2.6e-05      0.23      24      42 ..      11      29 ..       4      59 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 2.6e-05
        PhoD 24 edlDlvlhlGDyiYeygpg 42
                +++D+ ++ GD iYe +++
  EFC37506.1 11 DSVDFCIFAGDNIYEMEKN 29
                479************9633 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (124 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1022  (0.0570026); expected 358.6 (0.02)
Passed bias filter:                      458  (0.0255452); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 796.10
//
Query:       EFC37507.1  [L=1083]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   1.1e-156  508.5  82.9    8.5e-14   51.0   0.0   24.2 27  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.049   13.6   0.2         18    5.4   0.0    3.8  3  NitrOD1   Nitrosopumilus output domain 1
       0.46   10.7   5.1         37    4.6   0.0    4.7  5  GLTP      Glycolipid transfer protein (GLTP)
        3.2    7.9   7.9        1.7    8.7   0.0    4.4  4  DUF1154   Protein of unknown function (DUF1154)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.17   7.6e+02      19      44 ..      40      70 ..      34      73 .. 0.82
   2 !   23.2   0.0   9.3e-09   4.2e-05       7      49 .]      86     128 ..      85     128 .. 0.92
   3 !   17.8   0.4   4.5e-07     0.002       4      37 ..     108     141 ..     106     156 .. 0.82
   4 !   24.7   0.5   3.1e-09   1.4e-05       1      41 [.     130     175 ..     130     178 .. 0.90
   5 !   40.8   0.0   2.9e-14   1.3e-10       1      48 [.     160     207 ..     160     208 .. 0.96
   6 !   31.1   0.1   3.1e-11   1.4e-07       1      49 []     209     256 ..     209     256 .. 0.98
   7 !   39.7   0.1   6.4e-14   2.9e-10      15      49 .]     247     281 ..     243     281 .. 0.96
   8 !   48.0   0.2   1.6e-16   7.2e-13       1      41 [.     258     298 ..     258     299 .. 0.98
   9 !   32.3   0.2   1.3e-11     6e-08       1      33 [.     283     315 ..     283     319 .. 0.96
  10 ?    2.4   0.1      0.03   1.3e+02      16      44 ..     320     348 ..     317     351 .. 0.81
  11 ?   -3.5   0.0         2   8.8e+03       2      18 ..     355     370 ..     354     370 .. 0.61
  12 !   22.2   0.1   1.9e-08   8.4e-05       3      49 .]     381     428 ..     380     428 .. 0.94
  13 !   22.4   0.3   1.6e-08   7.3e-05      15      49 .]     419     453 ..     415     453 .. 0.91
  14 !   37.3   0.9   3.6e-13   1.6e-09       1      49 []     430     478 ..     430     478 .. 0.99
  15 !   35.2   0.1   1.6e-12   7.2e-09       1      40 [.     455     494 ..     455     495 .. 0.97
  16 !   37.8   0.7   2.5e-13   1.1e-09       1      43 [.     480     522 ..     480     551 .. 0.95
  17 !   17.2   0.1   6.8e-07     0.003       4      49 .]     534     576 ..     531     576 .. 0.83
  18 !   21.6   0.0     3e-08   0.00013       1      46 [.     553     598 ..     553     601 .. 0.94
  19 !   37.5   0.1   3.2e-13   1.5e-09       7      49 .]     638     680 ..     635     680 .. 0.93
  20 !   36.0   0.1   9.3e-13   4.2e-09       1      32 [.     682     713 ..     682     716 .. 0.96
  21 ?    2.6   0.0     0.025   1.1e+02      26      35 ..     729     738 ..     712     746 .. 0.66
  22 !   41.4   0.1   1.9e-14   8.4e-11       1      43 [.     752     794 ..     752     798 .. 0.98
  23 ?   -2.2   0.0      0.79   3.5e+03      26      33 ..     802     809 ..     800     809 .. 0.72
  24 !   33.8   2.1   4.6e-12   2.1e-08       1      49 []     823     896 ..     811     896 .. 0.86
  25 !   51.0   0.0   1.9e-17   8.5e-14       1      49 []     898     946 ..     898     946 .. 0.98
  26 !   38.1   0.0     2e-13   9.1e-10       1      49 []     948     996 ..     948     996 .. 0.98
  27 !   12.3   0.9   2.3e-05       0.1       1      31 [.     998    1028 ..     998    1037 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.17
     DUF4116 19 lseeLknDkei...vlkAvkqng..talsya 44
                +se+Lk +  i   +++ ++ +g  ++++++
  EFC37507.1 40 ISERLKLNESIyehMKQLIELHGvnKCIPFV 70
                8999999998888899999999976678776 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 9.3e-09
     DUF4116   7 eavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++++ +g+ l+++se+++nD  ++l Av+++ +al  +s +Lr
  EFC37507.1  86 KILSYCGLLLEFASERIRNDETLALIAVQNDVDALMDVSINLR 128
                 7899******************************998886665 PP

  == domain 3  score: 17.8 bits;  conditional E-value: 4.5e-07
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 ++l av+++  al  +s +L+ +++++lk v+ +
  EFC37507.1 108 LALIAVQNDVDALMDVSINLRENRDFALKVVQLD 141
                 6899***************************954 PP

  == domain 4  score: 24.7 bits;  conditional E-value: 3.1e-09
     DUF4116   1 DrEivleavkkngs......alkylseeLknDkeivlkAvkqngtal 41 
                 +r+++l++v+ + s        kyl+ ++k D eivlkAv+q+g++l
  EFC37507.1 130 NRDFALKVVQLDISnsykksTMKYLN-KFKDDYEIVLKAVRQCGISL 175
                 8*********99666778889999*9.*****************987 PP

  == domain 5  score: 40.8 bits;  conditional E-value: 2.9e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D Eivl+av+++g +l +   +L+ Dk+i+ +Avk++gtalsy+++++
  EFC37507.1 160 DYEIVLKAVRQCGISLANTAIRLRYDKQIIEEAVKSCGTALSYVPKDF 207
                 569******************************************997 PP

  == domain 6  score: 31.1 bits;  conditional E-value: 3.1e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr +v+ a++++ +al+y+  ++knDke+v +A +  ++++ +as+eL+
  EFC37507.1 209 DRNLVMSAISSDAKALQYAL-NFKNDKEVVFAAFQVGKDSFHFASDELK 256
                 9*****************98.9*************************97 PP

  == domain 7  score: 39.7 bits;  conditional E-value: 6.4e-14
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +++++s+eLk+D+e+++k vk ng+ ++++s+eL+
  EFC37507.1 247 SFHFASDELKSDREFCMKLVKLNGHTIRFCSDELK 281
                 799******************************97 PP

  == domain 8  score: 48.0 bits;  conditional E-value: 1.6e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 DrE+++++vk ng  ++++s+eLknDke ++ Avk++++++
  EFC37507.1 258 DREFCMKLVKLNGHTIRFCSDELKNDKEMAIIAVKSDPYSY 298
                 9*************************************998 PP

  == domain 9  score: 32.3 bits;  conditional E-value: 1.3e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkA 33 
                 D+E++  avk+++++++ l++++knD+ei+lk+
  EFC37507.1 283 DKEMAIIAVKSDPYSYYCLPPNMKNDREILLKC 315
                 9*******************************9 PP

  == domain 10  score: 2.4 bits;  conditional E-value: 0.03
     DUF4116  16 lkylseeLknDkeivlkAvkqngtalsya 44 
                 l  l+ ++++D+e++   + + +  l+++
  EFC37507.1 320 LFDLPYDISSDREFMNSLLISGKQLLNFL 348
                 55789999*******88888877777765 PP

  == domain 11  score: -3.5 bits;  conditional E-value: 2
     DUF4116   2 rEivleavkkngsalky 18 
                 r++ le++ +n ++++y
  EFC37507.1 355 RDFELELIGSN-CNYQY 370
                 56667777776.44666 PP

  == domain 12  score: 22.2 bits;  conditional E-value: 1.9e-08
     DUF4116   3 Eivleavkkngsalkyl.seeLknDkeivlkAvkqngtalsyaseeLr 49 
                 E+ + +v +++sa+ ++ s++++n+k+iv+ A+     +l  +seeL+
  EFC37507.1 381 ELFTRIVNIDPSAFMFAtSDNIRNNKQIVMNALFYEAEILGNISEELK 428
                 777899**********98****************************97 PP

  == domain 13  score: 22.4 bits;  conditional E-value: 1.6e-08
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +l ++seeLknD+e+   A++ + ++l+yas +Lr
  EFC37507.1 419 ILGNISEELKNDRELFELAIRLHDNVLYYASMNLR 453
                 5778**************************96665 PP

  == domain 14  score: 37.3 bits;  conditional E-value: 3.6e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+   a++ + ++l+y+s +L+nDk++v+  ++ + +++ yaseeL+
  EFC37507.1 430 DRELFELAIRLHDNVLYYASMNLRNDKDLVMMSIEYDAFSFQYASEELK 478
                 9**********************************************97 PP

  == domain 15  score: 35.2 bits;  conditional E-value: 1.6e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 D+++v+  ++ + ++++y+seeLknD++++  A+ +ng +
  EFC37507.1 455 DKDLVMMSIEYDAFSFQYASEELKNDRQVAELAITINGLN 494
                 9************************************976 PP

  == domain 16  score: 37.8 bits;  conditional E-value: 2.5e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 Dr+++  a+++ng++++++se+L+nDke+++ A +++ ++l+ 
  EFC37507.1 480 DRQVAELAITINGLNFQFASEDLRNDKEFCKLATRNSYHCLNE 522
                 9************************************999964 PP

  == domain 17  score: 17.2 bits;  conditional E-value: 6.8e-07
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++le vkk+ s   ++++e+k Dkeiv + v  +g +++ as +Lr
  EFC37507.1 534 LILENVKKHTS---FIPDEFKDDKEIVFESVSVYGGNIEQASFDLR 576
                 55555565444...9************************9999997 PP

  == domain 18  score: 21.6 bits;  conditional E-value: 3e-08
     DUF4116   1 DrEivleavkkngsalkylseeLkn.DkeivlkAvkqngtalsyase 46 
                 D+Eiv e v+ +g +++ +s +L+n D+e++  Av+ ng++ls +++
  EFC37507.1 553 DKEIVFESVSVYGGNIEQASFDLRNdDRELIRTAVR-NGCPLSSLDN 598
                 9************************888********.*****98876 PP

  == domain 19  score: 37.5 bits;  conditional E-value: 3.2e-13
     DUF4116   7 eavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++++ ++ ++ky+++ L+nDk++v k vk++g++l+y+se+++
  EFC37507.1 638 QILRGCWDWFKYFNPLLRNDKDFVRKYVKICGDILEYVSEDFK 680
                 56777889********************************986 PP

  == domain 20  score: 36.0 bits;  conditional E-value: 9.3e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 DrEiv+eav++  +a+ky+s+ LknD+eiv +
  EFC37507.1 682 DREIVKEAVSNSANAFKYASDTLKNDREIVEA 713
                 9****************************975 PP

  == domain 21  score: 2.6 bits;  conditional E-value: 0.025
     DUF4116  26 DkeivlkAvk 35 
                 D+e+vl+A +
  EFC37507.1 729 DRELVLQAAE 738
                 7777776654 PP

  == domain 22  score: 41.4 bits;  conditional E-value: 1.9e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 DrEi+l+ v+k gs l yls +L++D+eivl+Avk++ ++l+y
  EFC37507.1 752 DREIALKTVSKAGSKLLYLSYDLRSDREIVLEAVKNDHSSLEY 794
                 9***************************************998 PP

  == domain 23  score: -2.2 bits;  conditional E-value: 0.79
     DUF4116  26 DkeivlkA 33 
                 Dk+++lkA
  EFC37507.1 802 DKDVILKA 809
                 78888877 PP

  == domain 24  score: 33.8 bits;  conditional E-value: 4.6e-12
     DUF4116   1 DrEivleavkkngs.....................alkylsee....LknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vl++++k  +                      + yls+e    +k++kei+lkA+k  +ta++yas+eL+
  EFC37507.1 823 DRELVLKLLEKPLKkykyhfdiiddtieleyysgsQFVYLSDElkeeFKSNKEIMLKAIKFGPTAINYASKELQ 896
                 9*******888765778899*******99999999666666552222799**********************97 PP

  == domain 25  score: 51.0 bits;  conditional E-value: 1.9e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+vlea ++ng++l+++ +++k+++++v+kAv+qng +ls+a++eL+
  EFC37507.1 898 DEEFVLEAAQINGMVLNHVLPKFKHNRNVVMKAVQQNGMSLSHACNELQ 946
                 9******************99**************************97 PP

  == domain 26  score: 38.1 bits;  conditional E-value: 2e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D Eiv +a+k++ +a++y+  +L+ Dke+vl+  +qn +a+++as +L+
  EFC37507.1 948 DIEIVQNALKSHVCAFEYAGYKLRGDKEFVLEMTRQNYHAFKFASSDLQ 996
                 89*******************************************9996 PP

  == domain 27  score: 12.3 bits;  conditional E-value: 2.3e-05
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivl 31  
                  D++i+ +++++n + l+ +s +L+n+ ++++
  EFC37507.1  998 DEDIISQVMEINIETLNCASYSLRNNVDFLK 1028
                  9***************************987 PP

>> NitrOD1  Nitrosopumilus output domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0     0.065   2.9e+02      39      59 ..     555     575 ..     551     583 .. 0.86
   2 ?    1.2   0.0     0.083   3.7e+02      39      57 ..     659     677 ..     644     690 .. 0.82
   3 ?    5.4   0.0     0.004        18       8      31 ..     968     990 ..     965     993 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.065
     NitrOD1  39 eiverdvsisGdeieqinqkl 59 
                 eiv   vs+ G +ieq+   l
  EFC37507.1 555 EIVFESVSVYGGNIEQASFDL 575
                 99999***********98776 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.083
     NitrOD1  39 eiverdvsisGdeieqinq 57 
                 + v+++v i Gd +e +  
  EFC37507.1 659 DFVRKYVKICGDILEYVSE 677
                 6799*********998865 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.004
     NitrOD1   8 yklkGdkqyttcvvtriqyenfki 31 
                 ykl+Gdk++    +tr  y  fk 
  EFC37507.1 968 YKLRGDKEFVL-EMTRQNYHAFKF 990
                 *********75.789****99985 PP

>> GLTP  Glycolipid transfer protein (GLTP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.32   1.4e+03      22      51 ..     133     163 ..     109     173 .. 0.80
   2 ?    4.6   0.0    0.0083        37      16      62 ..     664     710 ..     640     724 .. 0.83
   3 ?   -3.3   0.0       2.1   9.6e+03      14      47 ..     757     790 ..     747     805 .. 0.76
   4 ?    1.2   0.0      0.09     4e+02      13      45 ..     927     959 ..     917     967 .. 0.85
   5 ?    2.0   0.1     0.053   2.4e+02      23      85 ..     987    1049 ..     974    1062 .. 0.67

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.32
                 GGGGGHHHHTHHHHHHHHHHTT.....T-SB CS
        GLTP  22 safsfvksDvegniekleeaykkn.peeyst 51 
                  a+++v+ D+++  +k +++y+++ ++ y+ 
  EFC37507.1 133 FALKVVQLDISNSYKKSTMKYLNKfKDDYEI 163
                 4899************999999987777765 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0083
                 HHHHT-GGGGGHHHHTHHHHHHHHHHTT....T-SBHHHHHHHHHHT CS
        GLTP  16 lfdllGsafsfvksDvegniekleeaykknpeeystleslveaEkee 62 
                  ++ +G +++ v++D +++ e+++ea+ ++ +++++  + ++++ e 
  EFC37507.1 664 YVKICGDILEYVSEDFKNDREIVKEAVSNSANAFKYASDTLKNDREI 710
                 4567799*********************9999999999999999753 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 2.1
                 HHHHHHT-GGGGGHHHHTHHHHHHHHHHTT.... CS
        GLTP  14 vklfdllGsafsfvksDvegniekleeaykknpe 47 
                 +k + + Gs +  ++ D++++ e++ ea+k++++
  EFC37507.1 757 LKTVSKAGSKLLYLSYDLRSDREIVLEAVKNDHS 790
                 5667778888889999999999999999998844 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.09
                 HHHHHHHT-GGGGGHHHHTHHHHHHHHHHTT.. CS
        GLTP  13 lvklfdllGsafsfvksDvegniekleeaykkn 45 
                 ++k +++ G  +s + ++++++ie++++a+k++
  EFC37507.1 927 VMKAVQQNGMSLSHACNELQNDIEIVQNALKSH 959
                 6777888899*****************999976 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.053
                  GGGGHHHHTHHHHHHHHHHTT........T-SBHHHHHHHHHHTT-TT..STT-HHHHHHHHHHHHH CS
        GLTP   23 afsfvksDvegniekleeaykknpe....eystleslveaEkeeglakkkkkesatrallwLkRgLe 85  
                  af+f++sD++g+ +++ + ++ n e    ++ +l++ v+  k+++    k+++   ra   L+R+++
  EFC37507.1  987 AFKFASSDLQGDEDIISQVMEINIEtlncASYSLRNNVDFLKRMN----KDNRLVERASFNLQRSIN 1049
                  9***************99999884424443334555554444331....245556666666666665 PP

>> DUF1154  Protein of unknown function (DUF1154)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.29   1.3e+03      10      23 ..     253     267 ..     251     267 .. 0.80
   2 ?   -4.3   0.3         4   1.8e+04      10      17 ..     278     285 ..     278     285 .. 0.85
   3 ?    8.7   0.0   0.00038       1.7      10      22 ..     500     512 ..     496     516 .. 0.88
   4 ?   -0.5   0.2       0.3   1.3e+03      12      20 ..     654     662 ..     653     666 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.29
     DUF1154  10 esLkqdKayl.KllK 23 
                 ++Lk+d++++ Kl+K
  EFC37507.1 253 DELKSDREFCmKLVK 267
                 89*******746665 PP

  == domain 2  score: -4.3 bits;  conditional E-value: 4
     DUF1154  10 esLkqdKa 17 
                 ++Lk+dK+
  EFC37507.1 278 DELKNDKE 285
                 78****95 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00038
     DUF1154  10 esLkqdKaylKll 22 
                 e+L++dK+++Kl+
  EFC37507.1 500 EDLRNDKEFCKLA 512
                 9**********97 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.3
     DUF1154  12 LkqdKaylK 20 
                 L++dK++++
  EFC37507.1 654 LRNDKDFVR 662
                 9******85 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1083 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1007  (0.056166); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.90u 0.32s 00:00:01.22 Elapsed: 00:00:00.53
# Mc/sec: 6111.86
//
Query:       EFC37508.1  [L=1832]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-28   97.2   3.4    5.3e-24   84.3   0.2    3.9  3  DUF4209      Domain of unknown function (DUF4209)
    8.5e-11   42.3   3.1    1.9e-10   41.2   0.3    3.1  3  Vps39_2      Vacuolar sorting protein 39 domain 2
  ------ inclusion threshold ------
       0.46   11.2   4.1        1.9    9.2   0.0    3.8  2  CdiI_2       CdiI immunity protein


Domain annotation for each model (and alignments):
>> DUF4209  Domain of unknown function (DUF4209)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.3   0.2   8.9e-28   5.3e-24       1      88 [.    1246    1339 ..    1246    1340 .. 0.98
   2 !   11.3   0.1   5.2e-05      0.31      39      87 ..    1513    1561 ..    1496    1563 .. 0.90
   3 ?   -3.3   0.0       1.9   1.1e+04      27      47 ..    1623    1643 ..    1605    1645 .. 0.76

  Alignments for each domain:
  == domain 1  score: 84.3 bits;  conditional E-value: 8.9e-28
     DUF4209    1 lErllrdlielagkktrkkkkekeklls......dlLaseelkeilgeelalilrvllgpprglNLRNvvwHGfiseeefsksllsllllllas 88  
                  lE+ lrd++ +++++++ +kk++e++l+      d+Las+++++i+g+++a+ilr+++g++++lNLRN+++HG++s+++f++++l++lll++ +
  EFC37508.1 1246 LEAGLRDCLIVYDFHCNIDKKKQESILNrlatfgDILASQDMSTIYGSSIAFILRMCYGSQNTLNLRNISMHGYFSKDNFHSQHLWFLLLVFSN 1339
                  79****************************************************************************************9976 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 5.2e-05
     DUF4209   39 ilgeelalilrvllgpprglNLRNvvwHGfiseeefsksllslllllla 87  
                   + e l++++  l+  p+g+ +R +++HG ++ + ++ks++ +l+ll++
  EFC37508.1 1513 DFSEGLVNCIYDLFKWPQGVRIRTLMAHGCVHWNWIPKSYVDRLILLII 1561
                  568889999999999*******************************997 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 1.9
     DUF4209   27 lsdlLaseelkeilgeelali 47  
                  +++lL+ e+++ il+ +++++
  EFC37508.1 1623 MKELLNAETVEVILEDNTRQA 1643
                  459999999999998887765 PP

>> Vps39_2  Vacuolar sorting protein 39 domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.46   2.7e+03      62      96 ..     608     642 ..     586     645 .. 0.80
   2 ?   -4.1   0.0         3   1.8e+04      29      51 ..     799     820 ..     780     833 .. 0.56
   3 !   41.2   0.3   3.2e-14   1.9e-10       2      78 ..    1007    1083 ..    1006    1087 .. 0.96

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.46
     Vps39_2  62 eeellklrskkvvvteekvCavCkkrlgesvfvvy 96 
                  +++ k++++ ++++   + ++Ck  + ++ f +y
  EFC37508.1 608 IHSMEKHSKEGIILDFAYMSQQCKSGIDNTLFKMY 642
                 44566888899999999999****99999999988 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 3
     Vps39_2  29 lesflekalrnslekkreeqvvk 51 
                 + + l k +r++l ++ +++v++
  EFC37508.1 799 IDPIL-KYIRQHLDEETQNEVIQ 820
                 33333.45666666666666654 PP

  == domain 3  score: 41.2 bits;  conditional E-value: 3.2e-14
     Vps39_2    2 elLskhaerldplevLdllPdelplkdlesflekalrnslekkreeqvvkklrkaeklsveeellklrskkvvvtee 78  
                   +L+k+a+++dp+++++llP++l+ k++ +fl  +lr++ +++r+++++k+++k +  +++ el+k +s+k  vt++
  EFC37508.1 1007 YILNKYAKHIDPISAIKLLPNNLSTKKILPFLTCTLRQTATNNRTTSIMKNMSKIDFFNAQAELVKYQSRKKFVTRK 1083
                  58********************************************************************9999976 PP

>> CdiI_2  CdiI immunity protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   2.5      0.95   5.7e+03      13      39 ..      51      77 ..      45      83 .. 0.83
   2 ?    9.2   0.0   0.00032       1.9      25      85 ..    1181    1241 ..    1173    1244 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.95
      CdiI_2 13 FhQDydlegdsieeiledYvssespee 39
                F+ D+d+ +++ e+ l+   s+e+++e
  EFC37508.1 51 FNNDFDDHHEEDEDSLALTDSDEDDNE 77
                9*************9988777776665 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00032
      CdiI_2   25 eeiledYvssespeevaelideieellassldee.leeaflaelgaefdpeawgltarefLe 85  
                   ++++++++ e  e+ ++li+ i e+l++sl++e +e +++  l++  + + ++ +  +fL+
  EFC37508.1 1181 YQAMKNFKNVERGELKRKLIGKIAEFLQLSLEKEdVEMMIEPILESLLNNS-NEESLTSFLT 1241
                  6899***************************99867766655555444444.6666767765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1832 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1060  (0.0591221); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.09u 0.33s 00:00:01.42 Elapsed: 00:00:00.54
# Mc/sec: 10256.92
//
Query:       EFC37509.1  [L=299]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.016   15.4   0.8      0.034   14.3   0.4    1.7  2  Tropomyosin_1  Tropomyosin like
      0.018   15.0   0.5      0.018   15.0   0.5    2.5  2  Laminin_II     Laminin Domain II
      0.071   12.7   0.4       0.12   11.9   0.4    1.3  1  PI3K_P85_iSH2  Phosphatidylinositol 3-kinase regulatory subun
       0.17   12.0   0.4        4.5    7.4   0.1    2.4  2  DUF5595        Domain of unknown function (DUF5595)
       0.31   11.6   1.9        1.1    9.7   0.4    2.3  2  DUF16          Protein of unknown function DUF16
       0.43   10.8   2.7       0.45   10.7   0.5    2.1  2  TMF_TATA_bd    TATA element modulatory factor 1 TATA binding
       0.72    9.9   5.5       0.35   10.9   1.4    2.3  3  DUF1664        Protein of unknown function (DUF1664)
        2.6    8.2   5.6         84    3.4   0.1    3.5  4  YojJ           Bacterial membrane-spanning protein N-terminus


Domain annotation for each model (and alignments):
>> Tropomyosin_1  Tropomyosin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.4   1.5e-05     0.034      14      91 ..       5      82 ..       3      88 .. 0.92
   2 ?   -2.9   0.0         3   6.7e+03      76     107 ..     160     192 ..     157     194 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.5e-05
  Tropomyosin_1 14 ekaeeleekvKeleqenlekeqeiksLtkknqqleeevekleeklkeakekaeesekkktnnealtrkiqlLEeelee 91
                   + ++e++++v++l+++  + +qei+   + ++ +e+ + k  + +++a+ ++ e +++  + e+l  k++ L + +e+
     EFC37509.1  5 DMYKEIKKNVRSLDETMDRTDQEIEHFGHVLDITEDGIAKFTNCISKAEVAVHEIDQLTNHGEELVSKLHALVNVVEN 82
                   56899**********************************************************999999888665555 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3
  Tropomyosin_1  76 ealtrki.qlLEeeleesdkkLkettekLretd 107
                    e++++ i + +E e+  s ++ + tt +L+ ++
     EFC37509.1 160 ESFKKTIlKKVEVEISPSTSTTNGTTSQLSSIE 192
                    555555435688888888888888888888776 PP

>> Laminin_II  Laminin Domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.5   8.2e-06     0.018      11      84 ..       6      82 ..       3      89 .. 0.84
   2 ?   -0.2   0.5      0.41   9.1e+02      17      39 ..     264     286 ..     243     298 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 8.2e-06
                XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XX--TTTTTGGGHHHHHHHHHH CS
  Laminin_II 11 takevleqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvk...kLeklapqLldklkelkqleea 84
                  ke+++ +  l++ +++t ++++++   ++ t++ + ++++ i  A+ +v    +L++  ++L++kl+ l +  e+
  EFC37509.1  6 MYKEIKKNVRSLDETMDRTDQEIEHFGHVLDITEDGIAKFTNCISKAEVAVHeidQLTNHGEELVSKLHALVNVVEN 82
                568999***************************************999888622256667789****9998776666 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.41
                 XXXXXXXXXXXXXXXXXXXXXXX CS
  Laminin_II  17 eqlaplsqnlentkeklseinrs 39 
                  + ++++ nle   + +s+i  +
  EFC37509.1 264 TISEAIKSNLESALQIASSISHT 286
                 33444555555555555555444 PP

>> PI3K_P85_iSH2  Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.4   5.5e-05      0.12      31     102 ..       5      78 ..       3      86 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.5e-05
  PI3K_P85_iSH2  31 keydqlkeeynkiseeiqlkrqaleaFneaikmFeeqiklqekfskea..qehEieklqenleqlksrlkelhs 102
                     +y ++k++  ++ e ++   q +e F+++  + e+ i+    ++++a    hEi++l+++ e+l s+l  l +
     EFC37509.1   5 DMYKEIKKNVRSLDETMDRTDQEIEHFGHVLDITEDGIAKFTNCISKAevAVHEIDQLTNHGEELVSKLHALVN 78 
                    589999999999999999999**********************999994469*****************99865 PP

>> DUF5595  Domain of unknown function (DUF5595)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.1     0.002       4.5      41      69 ..       2      30 ..       1      32 [. 0.94
   2 ?    2.1   0.0     0.091     2e+02      29      51 ..      60      82 ..      56      86 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.002
     DUF5595 41 kLkelynvdeaqlesleeeekrLeeEier 69
                 Lk++y+ ++++++sl+e   r  +Eie+
  EFC37509.1  2 GLKDMYKEIKKNVRSLDETMDRTDQEIEH 30
                69*************************96 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.091
     DUF5595 29 DtFeeedaeleskLkelynvdea 51
                D+ ++  +el skL  l+nv e+
  EFC37509.1 60 DQLTNHGEELVSKLHALVNVVEN 82
                67777889************987 PP

>> DUF16  Protein of unknown function DUF16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.4   0.00051       1.1      23      88 ..      15      80 ..       6      90 .. 0.82
   2 ?    0.3   0.0      0.42   9.5e+02      20      49 ..     154     180 ..     151     256 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00051
                HHHHHB-..BHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......HHHHH CS
       DUF16 23 kqlnefkdsnkqrLkkieakvdklgeqinkleqkvekqgekikelkveqkaqgeelnkvdetleli 88
                + l+e  d ++q+++++ + +d  +  i+k ++ ++k +  ++e+ +  +  +e + k++  ++++
  EFC37509.1 15 RSLDETMDRTDQEIEHFGHVLDITEDGIAKFTNCISKAEVAVHEIDQLTNHGEELVSKLHALVNVV 80
                578999999********************************9999887777666555554444444 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.42
                 -BHHHHHHB-..BHHHHHHHHHHHH...HH CS
       DUF16  20 VTrkqlnefkdsnkqrLkkieakvdklgeq 49 
                 VT   l+ fk   k+ Lkk+e +++     
  EFC37509.1 154 VTYSSLESFK---KTILKKVEVEISPSTST 180
                 7777788888...78888888888744333 PP

>> TMF_TATA_bd  TATA element modulatory factor 1 TATA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.5    0.0002      0.45      13      90 ..       6      83 ..       3      85 .. 0.93
   2 ?   -1.3   0.1       1.1   2.5e+03      29      54 ..     248     258 ..     217     289 .. 0.51

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0002
  TMF_TATA_bd 13 lverlsseirrlEgElaslkeelerleaerdeareeivklmkeneelkelkkeleelekeleelqeryetlLellGek 90
                 + +++++++r+l+  +  + +e+e + +  d +++ i+k ++   + + + +e+++l+++ eel +++ +l  +   k
   EFC37509.1  6 MYKEIKKNVRSLDETMDRTDQEIEHFGHVLDITEDGIAKFTNCISKAEVAVHEIDQLTNHGEELVSKLHALVNVVENK 83
                 5677899************************************************************99988776655 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.1
  TMF_TATA_bd  29 aslkeelerleaerdeareeivklmk 54 
                  a++               +e+ + ++
   EFC37509.1 248 ANA---------------DELSSTSS 258
                  322...............22333333 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   1.4   0.00016      0.35      45     123 ..       5      83 ..       1      84 [. 0.70
   2 ?   -1.0   0.0      0.76   1.7e+03      69      69 ..     189     189 ..     143     242 .. 0.51
   3 ?   -0.7   0.1       0.6   1.3e+03      51      90 ..     234     274 ..     217     289 .. 0.52

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00016
     DUF1664  45 svskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveglesklerieek 123
                 ++ k++++   sl +t ++  ++i++ ++ ld +++ +++ ++ +++++  ++ei++  ++ +e+v++l + ++ +e+k
  EFC37509.1   5 DMYKEIKKNVRSLDETMDRTDQEIEHFGHVLDITEDGIAKFTNCISKAEVAVHEIDQLTNHGEELVSKLHALVNVVENK 83 
                 4556666666777777777777777777777777777777777777777777777777777777888877777777765 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.76
     DUF1664  69 d 69 
                  
  EFC37509.1 189 S 189
                 2 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.6
     DUF1664  51 eqvseslaatkrhLssridrvdkkldeqk..eiskeikeevt 90 
                 ++vs+s ++ k +L++  d++ ++   ++   is++ik++++
  EFC37509.1 234 NNVSSSTRTSKSDLAN-ADELSSTSSTCSatTISEAIKSNLE 274
                 4555555555555543.2444444333330034444554444 PP

>> YojJ  Bacterial membrane-spanning protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.2     0.066   1.5e+02      14      37 ..       3      26 ..       1      46 [. 0.74
   2 ?    3.1   0.1     0.046     1e+02      26      61 ..      57      91 ..      43      93 .. 0.84
   3 ?   -2.7   0.0         3   6.7e+03      15      26 ..     164     175 ..     158     183 .. 0.62
   4 ?    3.4   0.1     0.037        84       3      31 ..     258     286 ..     256     293 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.066
        YojJ 14 lkeeLeqiekeleevlkaldeede 37
                lk + ++i+k++    +++d  d+
  EFC37509.1  3 LKDMYKEIKKNVRSLDETMDRTDQ 26
                677888888888888888888887 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.046
        YojJ 26 eevlkaldeedeClLcelesirekfaeletlassyY 61
                 e +++l +++e l ++l  + +++++ e+++ s+Y
  EFC37509.1 57 HE-IDQLTNHGEELVSKLHALVNVVENKEMIIMSFY 91
                44.5889999999**********************9 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3
        YojJ  15 keeLeqiekele 26 
                 k+ L+++e+e++
  EFC37509.1 164 KTILKKVEVEIS 175
                 344666666666 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.037
        YojJ   3 ekcleeelkeklkeeLeqiekeleevlka 31 
                 ++c+++ + e +k +Le + + ++ + ++
  EFC37509.1 258 STCSATTISEAIKSNLESALQIASSISHT 286
                 68999************999999988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1831  (0.102125); expected 358.6 (0.02)
Passed bias filter:                      651  (0.0363099); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.46u 0.24s 00:00:00.70 Elapsed: 00:00:00.41
# Mc/sec: 2183.30
//
Query:       EFC37510.1  [L=426]
Description: hypothetical protein NAEGRDRAFT_81892 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.025   15.2   0.0      0.046   14.3   0.0    1.5  1  Abhydrolase_6  Alpha/beta hydrolase family
      0.029   13.9   0.0       0.15   11.6   0.0    1.9  2  DUF900         Alpha/beta hydrolase of unknown function (DUF9
      0.033   13.7   0.1      0.087   12.4   0.0    1.7  2  LIDHydrolase   Lipid-droplet associated hydrolase


Domain annotation for each model (and alignments):
>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   7.6e-06     0.046      53      90 ..     303     346 ..     237     384 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 7.6e-06
                    H..HHHHCCTT..TTSEEEEEETCHHHHHHHHHHCC...........EE CS
  Abhydrolase_6  53 l..aalldelaagggpvvlvGHSlGGalalaaapla.........lvvg 90 
                    +  ++++ + a  +++vv+v+HS GG+  ++   l+         +v++
     EFC37510.1 303 YvwDHFVKKAA--AKDVVIVAHSAGGWCTME---LLkertqeclnRVRA 346
                    24477888887..99*************999...444446666654344 PP

>> DUF900  Alpha/beta hydrolase of unknown function (DUF900)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.13   7.7e+02      59     119 ..      10      70 ..       9      91 .. 0.65
   2 ?   11.6   0.0   2.5e-05      0.15      89     116 ..     310     337 ..     297     360 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.13
      DUF900  59 sagklldynyDresaeasrdalekllrylatkksakkihllaHSmGtwlvlealrqlaiea 119
                 s g+++d+  D+ s +  ++al + +++   ++++  + l   S   ++  ++++q+a+e 
  EFC37510.1  10 SFGSTFDFSTDKGSYSIPKQALIQYVEKAFLQEKKSFLLLPIPSSQDFIPFSVMEQIAKES 70 
                 5689999999999999999998777665444434444444445555555556666666555 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 2.5e-05
      DUF900  89 tkksakkihllaHSmGtwlvlealrqla 116
                 +k+ ak++ ++aHS G w ++e l++  
  EFC37510.1 310 KKAAAKDVVIVAHSAGGWCTMELLKERT 337
                 567899*****************98755 PP

>> LIDHydrolase  Lipid-droplet associated hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0      0.75   4.5e+03      58      77 ..      59      78 ..      51      84 .. 0.75
   2 ?   12.4   0.0   1.5e-05     0.087      68     109 ..     301     339 ..     290     376 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 0.75
  LIDHydrolase 58 vfsLedQiehkedflkelle 77
                   fs+ +Qi    + +++ +e
    EFC37510.1 59 PFSVMEQIAKESESVRKQME 78
                  68888888888888887765 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 1.5e-05
  LIDHydrolase  68 kedflkellekaksekdvklilvGHSvGaYialevlkrlser 109
                    + + +++++   ++  +++++v+HS G + ++e+lk+  ++
    EFC37510.1 301 TVYVWDHFVK---KAAAKDVVIVAHSAGGWCTMELLKERTQE 339
                   5555566775...668999*****************966554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (426 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      598  (0.0333538); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2520.09
//
Query:       EFC37511.1  [L=355]
Description: pantoate-beta-alanine ligase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.9e-77  258.7   0.0    6.6e-77  258.3   0.0    1.1  1  Pantoate_ligase  Pantoate-beta-alanine ligase


Domain annotation for each model (and alignments):
>> Pantoate_ligase  Pantoate-beta-alanine ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  258.3   0.0   3.7e-81   6.6e-77       3     265 ..       4     346 ..       2     347 .. 0.82

  Alignments for each domain:
  == domain 1  score: 258.3 bits;  conditional E-value: 3.7e-81
                      EESHHHHHHHHHHHHHTT-EEEEEEE-SS-GHHHHHHHHHHHHHSSEEEEEEEEEGGGSSTTSCTTTSEEEHHHHHHHHHHTT-SEEE--.-HH CS
  Pantoate_ligase   3 iktvaelrellkelrkegkkvglVpTmGaLHeGHlsLvkaakeendvvvvSiFvNplqFgpkedlekYPrtleaDlelleeagvdlvFaP.sve 95 
                       k+++e+++l k l ++gk v++VpTmG+LH+GHl+L+k ak+++dvvv S+FvNp+qF+++ed++kYPrtl++Dle+++e gvdlv aP  ++
       EFC37511.1   4 AKSLHEFQTLRKLLGNNGKVVSFVPTMGNLHSGHLQLMKIAKQNSDVVVSSVFVNPAQFAANEDFDKYPRTLQSDLEKMKEIGVDLVLAPgGTS 97 
                      56666666665556577888**********************************************************************6689 PP

                      HHST..............................EEEEECSGGCSTHHHHSTTHHHHHHHHHHHHHHHHT-SEEEEEGGGHHHHHHHHHHHHHT CS
  Pantoate_ligase  96 emyp..............................ttvevkelsevlegasrpghFrGVatvvtkLfnivqpdrayfGqKDaqqlavirrlvkdl 159
                      e+yp                               +++++ l+++ e   r+g+F+GV t+++kLfniv+p++++fGqKDa q++v++rlvkdl
       EFC37511.1  98 ELYPhgymtrvfmskistdtaqshplrnssgsvgEELNHNWLEDQPEAICRSGFFDGVSTILVKLFNIVRPQVIVFGQKDAVQCMVVKRLVKDL 191
                      99*8888888888888888888888999998888788888999999************************************************ PP

                      T-.S.SEEEEEEEEBETTSEBTTGGGGGS-HHHHHH.TTHHHHHHHHHH.............BHHHHH...............HHHHHHHH... CS
  Pantoate_ligase 160 nl.p.veivavpivReedgLAlSSRNkyLseeerka.AlvlykaLkaak.............eaealk...............eaakeele... 219
                      n+ +  ++++ ++ Re dgLA+SSRN+yLs+ +rk  A++l+++L +a+                  +               e++k++++   
       EFC37511.1 192 NYiDiEKVIIGETERELDGLAMSSRNQYLSPIDRKYiAPILNRILFDAQssfknienvnaesL----RkwlqdsynqlefsfeEKLKNHYSngy 281
                      985524799**********************988866************88877766655550....144444444444444433333333232 PP

                      THTTEEEEEEEEEETTTSS...................BSSB......SEEEEEEEEEETTEEEEEEE CS
  Pantoate_ligase 220 eeelekadyveivdaetleel.................eleee.....kkavllvaakvgkvrLiDni 265
                      ++e  k+dy++++++++ + +                 +   e     ++++l+++++vg +rL+Dn+
       EFC37511.1 282 NKEDYKIDYLSVCNWNNGHVYgtistnniytepfysieK---EnlqdlTQLCLSTTVRVGGTRLLDNL 346
                      2222346********999666999999888888886541...13456899*****************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       599  (0.0334096); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2138.74
//
Query:       EFC37512.1  [L=403]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (403 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1065  (0.059401); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2558.25
//
Query:       EFC37513.1  [L=726]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.2e-09   36.1   0.2    5.4e-09   35.3   0.2    1.3  1  Pkinase_fungal  Fungal protein kinase
    1.6e-06   27.7   2.4      4e-06   26.4   2.4    1.7  1  Pkinase         Protein kinase domain
     0.0045   16.3   0.3     0.0084   15.4   0.3    1.5  1  Pkinase_Tyr     Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.3   0.2     9e-13   5.4e-09     298     371 ..     534     605 ..     404     644 .. 0.75

  Alignments for each domain:
  == domain 1  score: 35.3 bits;  conditional E-value: 9e-13
  Pkinase_fungal 298 piekaespkelle.alrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesga 371
                     + + a+s+++l + ++++ I ++++L     iLH+DiS +N++i   k+++  + +LiD+D+ k++s++++e++ 
      EFC37513.1 534 KFKYANSKLQLCKlVIIESISILKQLD-SLDILHQDISLDNLMIR--KRNNLFELILIDFDFSKKYSKVENENSI 605
                     55667888888875789*********9.*****************..9999****************98888733 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   2.4   6.7e-10     4e-06      99     249 ..     544     705 ..     449     707 .. 0.74

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 6.7e-10
                 HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH......TTSCBSHHHHHHHHHHHHH CS
     Pkinase  99 eakkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtseYlAPEvl......keneyskkvDvWslGvily 188
                  +k ++ + ++ l+ l s  i+H D+  +N++i ++++   l ++DF+++k++++ +  ++ +  +++     +       e++ ++  D++s+ v+++
  EFC37513.1 544 LCKLVIIESISILKQLDSLDILHQDISLDNLMIRKRNNlfeLILIDFDFSKKYSKVE-NENSIREPNWTDFGSVtkhpywCEKKRTSVGDIYSMSVVIF 641
                 45556666666677888899**************88888999************988.6677777777776666444333356778889********** PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS....-HHHHHHHHHHT-SSG CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilgetkeklpeasei....seeakdllkkllkkdp 249
                 e+++   + + + +k+ ++  +      ++i+++ +++ +  +++     e++++l++ +l++++
  EFC37513.1 642 EIVYFLCVGR-NFSKQFYNLPVSSGRYRIEIVQCLQNDCDDLQQVlgkkFESFQKLMEYMLHYEQ 705
                 *987665555.333444555555544445555555555555555555558999999999999876 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.3   1.4e-06    0.0084     109     200 ..     549     645 ..     437     683 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 1.4e-06
                  HHHHHHHHHHHHHTTEEEST-SGGGEEEEETT...EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE......EEHHHHHHHHHHHHHH CS
  Pkinase_Tyr 109 alqvAkGmeyLeskklvHrdlaarNvLlsenk...vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk......ftsksDvWsfGvllwE 197
                  +++  + ++ L s +++H+d++  N ++++++      + Df  +++     + v++e++    +W+   s++++        ts  D++s +v+++E
   EFC37513.1 549 IIESISILKQLDSLDILHQDISLDNLMIRKRNnlfELILIDFDFSKKY----SKVENENSIREPNWTDFGSVTKHPywcekkRTSVGDIYSMSVVIFE 642
                  444455678899999*************996633446789******99....56677777888899999888876645554489999*********** PP

                  HHT CS
  Pkinase_Tyr 198 ift 200
                  i+ 
   EFC37513.1 643 IVY 645
                  *86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (726 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       916  (0.0510904); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 4480.22
//
Query:       EFC37514.1  [L=1080]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      2e-15   56.8  13.2      2e-15   56.8  13.2    4.7  4  TIMELESS    Timeless protein


Domain annotation for each model (and alignments):
>> TIMELESS  Timeless protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.8  13.2   1.1e-19     2e-15       6     274 ..      92     397 ..      87     398 .. 0.74
   2 ?   -1.8   0.1     0.081   1.5e+03     228     259 ..     401     432 ..     396     441 .. 0.64
   3 ?   -2.8   0.1      0.17   3.1e+03     213     246 ..     710     743 ..     699     751 .. 0.61
   4 ?  -24.8  31.0         1   1.8e+04     227     261 ..     979    1013 ..     832    1027 .. 0.84

  Alignments for each domain:
  == domain 1  score: 56.8 bits;  conditional E-value: 1.1e-19
    TIMELESS   6 ddclecLkdLkrwlrlDdddnrrdvaralaeakilqndLipiLiqweekkkklalaclrLlvaLTwPlelleeee...........eteeqtahytqlk 93 
                 + c+e+L+dL+ + ++D ++ +r+v  +l e++i +n+L  +L ++++ + +++  +++Llv+L    + ++  +           e + ++  + ++ 
  EFC37514.1  92 KACIESLQDLQEITKEDLTKRERRVWTLLIETNIHKNELFSLLSHHRN-DYDIVREVIDLLVILSESPDQNNP-RfrkfsarggasERKRAIFYFGKQM 188
                 68*******************************************999.****************66665333.24678888**988888999999*** PP

    TIMELESS  94 kalleyKaailsee.............kgkvlkalvrlllevlakdr.........eerterdegiieliLtLiRNilaiedpqekeksasskkeddil 170
                 k l+++K+a+ls++             ++ +lk             +         +  te+d   i  i+ L+ N+l+i+d+++ ++  +++ + + +
  EFC37514.1 189 KILQRFKQALLSTKylpiiswtlmnkeNESALKS------------KmiideenkrRVLTEADLYFI-AIFKLLNNLLSIPDAKHGKVLQTEELQ-TRM 273
                 ***********99644444444443333333332............123332221144455555444.588999*********888888888777.99* PP

    TIMELESS 171 hskliealees.gvld.llltlassigkef.........eqeqfnllllEiiylllkgqdpeeLa.........kesekesrstkeasrasdelsklle 249
                 ++ l+++l++  ++ld  l+ +++ i++ +         +  +  ll+     +l+ + ++++L+         +++   s+++++ + +++el++ll 
  EFC37514.1 274 QDVLVKQLQNDcQFLDyALVKMTKFIENYNevssqsemkRLSESYLLFTKFATMLFWNESVKDLFeasnpiipnSNDIVMSQNEENMEMDNSELKRLLR 372
                 ********986245552677788777755554444433333334455555566666666666666********95566666777777899********* PP

    TIMELESS 250 kekakkkasikkna.stRHsrFggtl 274
                 kek  k + +     + RHsrF+g+l
  EFC37514.1 373 KEKMYKDQVK-SLIlTGRHSRFQGSL 397
                 ***6666666.54459*******976 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.081
    TIMELESS 228 ekesrstkeasrasdelskllekekakkkasi 259
                 e++ ++  ++++++++ls+lle++++   ++ 
  EFC37514.1 401 ESNVSKVISKNKDAQKLSALLEENEEYDAEKE 432
                 44445555677888999999988776555544 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 0.17
    TIMELESS 213 lllkgqdpeeLakesekesrstkeasrasdelsk 246
                  + +++++e+++ +s+k ++st+e++++++e  +
  EFC37514.1 710 VINENISIEAFFMKSKKGESSTTEDEEEEEENDS 743
                 4556788899996666666666665555554444 PP

  == domain 4  score: -24.8 bits;  conditional E-value: 1
    TIMELESS  227 sekesrstkeasrasdelskllekekakkkasikk 261 
                  ++++++s+k+++r+++e ++  ++e+++kk+++kk
  EFC37514.1  979 KKDKKKSKKRKERDEEETEETEDTERSEKKKKKKK 1013
                  44455555555566666666666666655555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1080 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3892  (0.217078); expected 358.6 (0.02)
Passed bias filter:                      976  (0.0544369); expected 358.6 (0.02)
Passed Vit filter:                       602  (0.0335769); expected 17.9 (0.001)
Passed Fwd filter:                       174  (0.00970495); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 2.71u 0.40s 00:00:03.11 Elapsed: 00:00:00.74
# Mc/sec: 4431.67
//
Query:       EFC37515.1  [L=116]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       353  (0.0196888); expected 358.6 (0.02)
Passed bias filter:                      263  (0.014669); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 711.26
//
Query:       EFC37516.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1707  (0.0952089); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.69u 0.34s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 2872.10
//
Query:       EFC37517.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       613  (0.0341904); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1277.21
//
Query:       EFC37518.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.098   13.1   5.1       0.11   13.0   3.9    1.6  1  CYYR1     Cysteine and tyrosine-rich protein 1


Domain annotation for each model (and alignments):
>> CYYR1  Cysteine and tyrosine-rich protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   3.9     6e-06      0.11      42      85 ..      55      97 ..      39     105 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 6e-06
       CYYR1 42 syyayvgdvlsgtaiagivfgvvflmgvvagialcvcmcvknsr 85
                + y  +  v++g +i+g+vf vv+l  +va+ ++cv +cv +++
  EFC37518.1 55 TNYINLTGVIAG-SISGLVFLVVILPTIVACSLMCVLVCVTEEK 97
                566777778887.69************************98876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       622  (0.0346924); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2265.28
//
Query:       EFC37519.1  [L=222]
Description: hypothetical protein NAEGRDRAFT_81898 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-07   30.6   0.2    3.8e-07   30.2   0.2    1.2  1  SPRY      SPRY domain


Domain annotation for each model (and alignments):
>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.2   0.2   2.1e-11   3.8e-07       2     118 ..      55     184 ..      54     186 .. 0.78

  Alignments for each domain:
  == domain 1  score: 30.2 bits;  conditional E-value: 2.1e-11
                 EEEEEEETCCTSSEEEEEEEETTSSSSSTSSS.TSSTTEEEEETETTEEE.EETESCEEEESSSS.....TTSEEEEEEETTTTEEEEEETT....EEE CS
        SPRY   2 hyfevkiqsaeggsisvGlateqtdlsdksge.gddrgswglcgdngtrt.saeqskaygkqpar.....egdviGvalDleegelsFtkng....knl 89 
                  yfevk+  ++ +++ +G+  ++   +d++   g+d + +g++ dng+++ +++ +++ ++ + +      ++v G +lD+e ge + t ng     +l
  EFC37519.1  55 TYFEVKLC-QTLTKLFIGFGFTSSESHDDEDIvGWDTDTIGFHYDNGRVYqETSFTAPIAD-KLHlvdvkGDEVFGFFLDHEIGEFKVTCNGrllhNSL 151
                 5******9.999999999988888877666667****************975555555555.4444555255699*****************6666666 PP

                 EEEEESTTTS..SEEEEEEE...STCEEEEESS CS
        SPRY  90 gvaFrnvrga..elfPvvslg..ngaslkinlg 118
                 g+ F+ ++ +   + P++s+       ++inlg
  EFC37519.1 152 GTRFTMEKYKkkIFKPMISVDcgMRVEMEINLG 184
                 999999888776888****99555566666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       269  (0.0150036); expected 358.6 (0.02)
Passed bias filter:                      237  (0.0132188); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1465.57
//
Query:       EFC37520.1  [L=489]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.8e-15   54.6  26.5    4.4e-08   32.8   7.5    3.1  3  ZZ          Zinc finger, ZZ type
     0.0027   17.6   0.0     0.0068   16.3   0.0    1.7  1  F-box-like  F-box-like
  ------ inclusion threshold ------
       0.54   10.6  29.7        0.2   12.0  10.3    3.6  3  C1_2        C1 domain
       0.61    9.9   3.1        1.5    8.6   1.1    2.3  2  DUF4412     Domain of unknown function (DUF4412)


Domain annotation for each model (and alignments):
>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.3      0.63   2.8e+03       5      10 ..     174     179 ..     167     181 .. 0.72
   2 !   32.8   7.5   9.8e-12   4.4e-08       4      37 ..     269     301 ..     268     308 .. 0.90
   3 !   31.8   5.0   2.1e-11   9.4e-08       4      40 ..     335     370 ..     333     374 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.63
                 EE-TTT CS
          ZZ   5 ytCdgC 10 
                   Cd+C
  EFC37520.1 174 RDCDKC 179
                 468888 PP

  == domain 2  score: 32.8 bits;  conditional E-value: 9.8e-12
                 -EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH CS
          ZZ   4 kytCdgCseapligvRyhclrcsdYDLCqsCfst 37 
                 +y+Cd+C e p+ g Ry cl c +YDLC  C  +
  EFC37520.1 269 EYSCDICEE-PIYGIRYNCLDCGEYDLCGYCCEK 301
                 79*******.*******************99765 PP

  == domain 3  score: 31.8 bits;  conditional E-value: 2.1e-11
                 -EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH.H- CS
          ZZ   4 kytCdgCseapligvRyhclrcsdYDLCqsCfsthka 40 
                  y+C++C+e  + g Ryh l   dYDLC  Cf+  ++
  EFC37520.1 335 TYSCNQCKE-KIRGHRYHKLDETDYDLCTLCFFDTNS 370
                 69*******.**********************98554 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   1.5e-06    0.0068      10      45 ..      63      98 ..      60     100 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.5e-06
  F-box-like 10 lqIFsyLppsdLlr.lalVCrrWrrvaldtplLWrrl 45
                 +I+syL+ +dL+  +  +C+ ++++  ++ +LW +l
  EFC37520.1 63 TKILSYLDEYDLALsIQPTCKLFQNFSKND-QLWEKL 98
                69*********98878***********999.***987 PP

>> C1_2  C1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       3.3   1.5e+04      19      24 ..     174     179 ..     166     185 .. 0.65
   2 ?   12.0  10.3   4.6e-05       0.2      13      46 ..     264     298 ..     214     299 .. 0.87
   3 ?    6.7   7.1     0.002       8.9       3      46 ..     321     364 ..     318     365 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3.3
        C1_2  19 fnCsaC 24 
                 + C+ C
  EFC37520.1 174 RDCDKC 179
                 556555 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 4.6e-05
        C1_2  13 edssesfnCsaCgrkidgffYsCseC.dfslhvrC 46 
                 e++  +++C++C+++i g +Y+C  C ++ l+  C
  EFC37520.1 264 EEELPEYSCDICEEPIYGIRYNCLDCgEYDLCGYC 298
                 4555679*******************77***9998 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.002
        C1_2   3 HpHpLtlskgedssesfnCsaCgrkidgffYsCse.CdfslhvrC 46 
                 H+H+ + + +e++  +++C+ C++ki g +Y+     d+ l+  C
  EFC37520.1 321 HDHTFQSV-DEEEFTTYSCNQCKEKIRGHRYHKLDeTDYDLCTLC 364
                 56666666.8999999**************986333677777666 PP

>> DUF4412  Domain of unknown function (DUF4412)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   1.1   0.00034       1.5      92     136 ..     289     333 ..     283     351 .. 0.80
   2 ?   -0.0   0.0      0.14   6.5e+02     169     187 ..     409     427 ..     389     429 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00034
     DUF4412  92 lGketikGYsCehvritskeetlelWvtkdlldfatfarlqsqne 136
                  G+  + GY Ce+v ++ k +tl ++   d    +tf+ + +++ 
  EFC37520.1 289 CGEYDLCGYCCEKVIMKQKGSTLKMCQHADHPHDHTFQSVDEEEF 333
                 5778899*******************9999888888887776655 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.14
     DUF4412 169 vmelvkiekksldaslFev 187
                   e+ +++kk+l a+lFe+
  EFC37520.1 409 GEEVANMTKKQLSAKLFEI 427
                 56999************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1262  (0.0703888); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.47
# Mc/sec: 3115.09
//
Query:       EFC37521.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1591  (0.0887389); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.24s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 3263.79
//
Query:       EFC37522.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-13   48.9   0.2    6.8e-13   48.6   0.2    1.2  1  Cyt-b5    Cytochrome b5-like Heme/Steroid binding domain


Domain annotation for each model (and alignments):
>> Cyt-b5  Cytochrome b5-like Heme/Steroid binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.6   0.2   3.8e-17   6.8e-13      10      73 ..      47     108 ..      34     109 .. 0.87

  Alignments for each domain:
  == domain 1  score: 48.6 bits;  conditional E-value: 3.8e-17
                 CTTEEEEEETTEEEECTTTCCCSTTCSHHHHTTTTSBBHHHHHHTTGGCHHHHHHHHGGEEEEE CS
      Cyt-b5  10 gkndlwvairgkVYDvskflskhpGgesailkyaGkDateafksvvhsekdaekllkkylvGkl 73 
                  k+++w++++g V D++ f ++hpGg+ ai +ya kDat++f s  h +  ++k+ k++++G++
  EFC37522.1  47 AKSECWMVVDGYVVDCTGFDKDHPGGAYAIVQYAKKDATDIFLSS-HGKRGVAKM-KALAIGTI 108
                 5679*****************************************.989989999.77999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       984  (0.0548832); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 786.66
//
Query:       EFC37523.1  [L=592]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.2e-49  166.6   0.5    2.3e-48  164.5   0.5    2.0  1  Copine           Copine
    6.5e-21   74.6   0.2    1.1e-10   41.7   0.0    2.6  2  C2               C2 domain
    0.00026   21.1   0.1      0.002   18.3   0.0    2.3  2  vWA-TerF-like    vWA found in TerF C terminus
  ------ inclusion threshold ------
      0.088   12.7   0.2       0.39   10.6   0.1    2.1  2  Post_transc_reg  Post-transcriptional regulator


Domain annotation for each model (and alignments):
>> Copine  Copine
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  164.5   0.5   5.2e-52   2.3e-48       1     217 [.     357     580 ..     357     581 .. 0.89

  Alignments for each domain:
  == domain 1  score: 164.5 bits;  conditional E-value: 5.2e-52
      Copine   1 sLHyispeqpneYekallsvgeilqaydsdklipafGFGaklpsdaevsdefvlnfneenkevegiegvleaYrealpnlql......ygPT....... 86 
                 sLH +s  ++n+Y++al++v++il++yd dk++ a+G+Ga +   + ++  f+l++++ ++e +g +++l+aY +alp+l+       + P        
  EFC37523.1 357 SLHHLS-GKQNQYQQALSQVMNILEPYDVDKMYAAYGYGATV-DGKGMKPMFNLSLTD-QEELHGAQEILTAYANALPRLSFgdmgsaTNPKtkqrywg 452
                 89***9.899******************************64.456789999999976.5689*****************7533222122322333333 PP

      Copine  87 .nfapviekvakiaeasakeasqYfvLliitDGvvtdmketidaivaAsklplSiiivGvGdadfekmreldddd.alkssdgriakRdivqfVdfrdl 183
                  +f  +ie v+++  + +++++ Y +Ll+i DG   dm++ti++iv+A + p+SiiivGvG+++f++ r++d+dd  l +s+g+ ++RdivqfV f d 
  EFC37523.1 453 dDFYRLIECVVEKTPKIHQNHQFYNILLLIIDGDSFDMQSTINSIVDANDKPISIIIVGVGNSNFSNCRKFDADDePLVHSNGKKMTRDIVQFVRFADC 551
                 36999***********9999999***************************************************999********************** PP

      Copine 184 ksnasakeaalakavLaeiPkqlkaylelrklkp 217
                  s      ++lak+vLae+Pkql++++e++k+ p
  EFC37523.1 552 SS-----VEELAKQVLAEVPKQLVTFFEAKKIVP 580
                 99.....899*****************9998865 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.0     1e-10   4.6e-07      17      85 ..       2      86 ..       1     102 [. 0.85
   2 !   41.7   0.0   2.5e-14   1.1e-10       7      94 ..     173     267 ..     169     273 .. 0.84

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 1e-10
                STTSSCEEEEEEEE................ECEEEEEE-SCSSSSSSEEEEEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEE CS
          C2 17 dkkgssdpyvkvsl................dgkqkakTrviknslnPvWnekftfevaeleeakLeveVfdndrlskddfiGkve 85
                d  ++sdp++k+++                + +  +kT++i+n+ nP + +kf++  +++ ++kL ve++d+d  ++++++Gk++
  EFC37523.1  2 DLLSKSDPFAKLYYmgpstsgssnqpiistSFTCLGKTETIQNNSNPSFAKKFSLYYYFEYSQKLNVEIYDDDGKNNSQLMGKTQ 86
                5567788888888888888888888888777789999**9*8888*************9**************999999***985 PP

  == domain 2  score: 41.7 bits;  conditional E-value: 2.5e-14
                 EEEEESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEE.EEEEEEESC.HTTSEEEEEEEEECSSSTEEEEEEEEEEGHH.HHTT CS
          C2   7 vieAknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWn.ekftfevae.leeakLeveVfdndrlskddfiGkveiplst.llsg 94 
                 v++A+nL +kd +g+sd +   +     ++++ ++++vi+++lnP W   ++++++ + + ++ ++v+++d+d+ s+ d+iG++++ l++ +++g
  EFC37523.1 173 VCCARNLDKKDLFGKSDGFFYFEKdvasRREKLYQSEVIQKNLNPDWAtFSLNLDLFNnDFNKNIHVKCYDHDKHSDADLIGEFSFTLDEvINQG 267
                 789**************966655555999999***************435666666669***************9999***********943333 PP

>> vWA-TerF-like  vWA found in TerF C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.19   8.7e+02      73      96 ..     355     378 ..     267     389 .. 0.73
   2 !   18.3   0.0   4.4e-07     0.002      85     189 ..     454     567 ..     417     578 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.19
  vWA-TerF-like  73 gllelkklggvneeapvleevlek 96 
                    ++   +  g++n+++++l++v++ 
     EFC37523.1 355 SNSLHHLSGKQNQYQQALSQVMNI 378
                    222334457889999999998865 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 4.4e-07
  vWA-TerF-like  85 eeapvleevlekvrk..epaelptlvlFitDGgvkkkkeiekalreaskepiFwqFvglgkseygvLeklDdl.........egRvvDNagFfavd 169
                    +  + +e v+ek  k  ++++   ++l i DG+  + +++ + + +a ++pi    vg+g+s++   +k+D           ++ + D ++F    
     EFC37523.1 454 DFYRLIECVVEKTPKihQNHQFYNILLLIIDGDSFDMQSTINSIVDANDKPISIIIVGVGNSNFSNCRKFDADdeplvhsngKKMTRDIVQFVRFA 549
                    55567777777776653455667788999*****************************************97533445654444555777777777 PP

  vWA-TerF-like 170 didkvsdaeLYdrLlsefpe 189
                    d ++v+  eL +++l+e p+
     EFC37523.1 550 DCSSVE--ELAKQVLAEVPK 567
                    777664..566666666665 PP

>> Post_transc_reg  Post-transcriptional regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   8.7e-05      0.39       3      68 ..     269     331 ..     268     335 .. 0.94
   2 ?   -2.4   0.0      0.97   4.4e+03      33      52 ..     459     478 ..     457     482 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 8.7e-05
  Post_transc_reg   3 elkeklepalksKveEfkllgYdriteediwnylvekkwKkkeelrlhelvqdilslkineymsyl 68 
                      ++ + +ep l sK +++k  g+ + t+ +i   +++++ K++ el++++ v ++ + ++ e+m+yl
       EFC37523.1 269 KQFDLIEPTLASKKKNYKNSGIFEFTDCQI---IIKQEPKQNPELSIYNQVIALKENRNAEFMDYL 331
                      567889*********************998...79******************************8 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.97
  Post_transc_reg  33 wnylvekkwKkkeelrlhel 52 
                       +++vek  K +++ +++++
       EFC37523.1 459 IECVVEKTPKIHQNHQFYNI 478
                      589*******8888777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (592 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.41
# Mc/sec: 4339.84
//
Query:       EFC37524.1  [L=1077]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-10   41.2   0.1    1.2e-10   41.2   0.1    2.0  2  GSAP-16   gamma-Secretase-activating protein C-term


Domain annotation for each model (and alignments):
>> GSAP-16  gamma-Secretase-activating protein C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.2   0.1   6.9e-15   1.2e-10      17      95 ..     749     828 ..     737     840 .. 0.87
   2 ?   -3.7   0.4      0.64   1.1e+04      85     105 ..     893     913 ..     892     915 .. 0.77

  Alignments for each domain:
  == domain 1  score: 41.2 bits;  conditional E-value: 6.9e-15
     GSAP-16  17 ldpllelidelksseelalFhllerlleal.eelafPlPpgFhslftvLGvrcLplstflqYidngvleltedvvkkllk 95 
                 ++ l e+i ++k++ee  +F l+e ++++l  +  +P P++F+  f++ G+++L++++f qY d+gv+e++++v+++l +
  EFC37524.1 749 MELLSETIMSQKNEEEKYFFILMECFYTSLlLDYRLPPPAEFNFNFVISGFKALERDIFYQYCDRGVFEINNQVINALCQ 828
                 45556799******************99862799*****************************************99876 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 0.64
     GSAP-16  85 ltedvvkkllkdlddteenek 105
                 l+++ +kk+lk+ ++++++e+
  EFC37524.1 893 LNQNSLKKILKKKQKKHNQER 913
                 678889999999888777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1077 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1243  (0.069329); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.89u 0.32s 00:00:01.21 Elapsed: 00:00:00.52
# Mc/sec: 6176.64
//
Query:       EFC37525.1  [L=134]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (134 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       491  (0.0273858); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 796.06
//
Query:       EFC37526.1  [L=155]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.3e-29  100.6   2.1    6.7e-29  100.3   2.1    1.1  1  DUF4112   Domain of unknown function (DUF4112)


Domain annotation for each model (and alignments):
>> DUF4112  Domain of unknown function (DUF4112)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.3   2.1   3.7e-33   6.7e-29       5     104 ..      19     121 ..      16     122 .. 0.93

  Alignments for each domain:
  == domain 1  score: 100.3 bits;  conditional E-value: 3.7e-33
     DUF4112   5 vrklayllDkalripgcglr....fGldpiigliPvvGdvisallslylvleakkaeglpkslllrmlvnialDlliglvPvvGdlfdvlfkantrNaa 99 
                 ++ l++l+D++++i++  +r    fG+dpi+g++P+vGd+is+++s++++  + +++g++ s+l+rm vni+lD+lig++P++G++fd++fkan+rN +
  EFC37526.1  19 IQYLSFLMDSSFHITIPIIRkrisFGFDPIFGFVPFVGDFISFGVSCLILIMI-WRHGMSFSILCRMGVNIVLDFLIGCIPIIGTIFDFFFKANKRNWK 116
                 678899****99887766666677*****************************.9******************************************** PP

     DUF4112 100 llekh 104
                 +l k+
  EFC37526.1 117 MLCKY 121
                 **987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (155 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       621  (0.0346366); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.38u 0.24s 00:00:00.62 Elapsed: 00:00:00.40
# Mc/sec: 1168.95
//
Query:       EFC37527.1  [L=116]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-33  114.1   1.4    2.7e-33  113.9   1.4    1.0  1  DUF962    Protein of unknown function (DUF962)


Domain annotation for each model (and alignments):
>> DUF962  Protein of unknown function (DUF962)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.9   1.4   1.5e-37   2.7e-33       1      94 [.      17     111 ..      17     112 .. 0.95

  Alignments for each domain:
  == domain 1  score: 113.9 bits;  conditional E-value: 1.5e-37
      DUF962   1 lksleefyafYlaeHsnpinrllHfigvplilltvlllllraklkllla.lfvvgyifafvGHfvfEkrkPAlfknplqsllidplmvllellgk 94 
                 ++s++efy+fYl++Hsnpi+r lH++g+  ++ t  +ll+ +k++l+l  ++++gy++a++GHf+fEk++PA+f++pl+s+++d+ m++++l+++
  EFC37527.1  17 YQSFAEFYPFYLSQHSNPICRILHVVGTFSAASTGGYLLYKKKYQLALPsMLLIGYGLAWIGHFFFEKNRPATFTYPLWSFMGDWKMMFEVLTFQ 111
                 589*****************************************9998615689************************************99976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       353  (0.0196888); expected 358.6 (0.02)
Passed bias filter:                      271  (0.0151152); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 793.05
//
Query:       EFC37528.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.2e-61  206.0   0.0    1.2e-60  205.6   0.0    1.0  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  205.6   0.0   6.7e-65   1.2e-60       6     389 ..      45     446 ..      41     454 .. 0.85

  Alignments for each domain:
  == domain 1  score: 205.6 bits;  conditional E-value: 6.7e-65
                 EHHCCHCHHHHTTTCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEES.SHHHHHHHHHTTTTSSSTTCGH.HHHHHHHHHH CS
        p450   6 plplvgnllqlgrkeelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrp.deallatsrkpfkgkgvlfang.ekwkklRrfl 102
                  +pl+  +l +g  ++  + +++l     +++r+ +  +++v +++ ++ ke+l+ kg++f ++   + +++t   +  +   ++++g e+wk+++r+ 
  EFC37528.1  45 SYPLISPFLSFGGFRNTEKLMNDLGDPKTKTVRIAMYDRNIVSICDKDMLKELLVVKGNNFIKQAkIYEVFNT---FGINILSALDAGgETWKNHHRVA 140
                 67888888888888899999999999999**************************999666553203333333...4455555666668********** PP

                 HHHHTSHSTTTHHHHHHHHHHHHHHHHHCCCCHCS.........EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSH......HHHHHHHHHHHHH..HH CS
        p450 103 tptltsfgklsleelveeeaedlveklrkkagess.........elditellskaaldvigsilFgarfdlledek......lselvkaveelss..ll 184
                   ++ s+ +l++++ + + + dl++  + +++ ++          +d   ++s+++ldv+g+  Fg  f+ + dek      +    +  e++++  + 
  EFC37528.1 141 SGAFASK-NLEFMADIASNTVDLIRDYKWEKEMKKaldsgnkgfIFDSNADFSDMTLDVLGKAGFGLDFS-IFDEKsdegkiF---RRSLEKMFTlgVI 234
                 *******.8877777778888888776666666668899999999*************************.666663554442...3333344434466 PP

                 HCHHHHCCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC........SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHH CS
        p450 185 skssvqllllfpllkylptkllrklkeavkklkdlldklieerretldsa........kksrrdfldalllakkekkgesklsdeelaatvlellfaGv 275
                 +k++  l+ l ++++++ +k    +++avk+++d ld++i er ++++s+         ++r+d+l++l++a   +kg   lsd+el+  +  + +aG+
  EFC37528.1 235 AKRFIGLNPLLSWAFPFVSKVTG-VDDAVKIVSDKLDQIISERTKEVESKgieeistgGEERKDLLSVLVEANFIQKGV--LSDAELKSDAYIFSLAGH 330
                 78888888888899888877765.56688*****************************779***********8677775..****************** PP

                 HHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHC..CTTT.T-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHH CS
        p450 276 dTtsstlswaLyeLaknPevqeklreEidevl..gdkr.eptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalh 371
                 +Tts+tl+w+ yeL k+Pe+q+k reEid +l  g +r  p y+d   + y++avi E+LRlhp+v+ ++ R+++k ++++++ ipk+t++ +n+ a +
  EFC37528.1 331 ETTSTTLQWVCYELSKRPEIQKKAREEIDATLgvGANRrAPNYNDYPIMNYVNAVIMEALRLHPPVV-NVFRVAKKSTTLGEFAIPKDTTIHINIFAAN 428
                 *******************************95544446****************************.******************************* PP

                 T-TTTSSSTTS--GGGGB CS
        p450 372 rdpevfpnPeeFdpeRFl 389
                 r+++ +++P eF peR+ 
  EFC37528.1 429 RSEKNWEKPLEFIPERYP 446
                 ****************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       587  (0.0327403); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.27s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 3413.90
//
Query:       EFC37529.1  [L=494]
Description: cytochrome p450 family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-48  165.9   0.0    1.3e-37  129.7   0.0    2.1  2  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.4   0.0   5.8e-13     1e-08      35     190 ..      90     248 ..      79     257 .. 0.79
   2 !  129.7   0.0   7.3e-42   1.3e-37     258     445 ..     256     469 ..     252     483 .. 0.91

  Alignments for each domain:
  == domain 1  score: 34.4 bits;  conditional E-value: 5.8e-13
                 SEEEEEETT.EEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHHTSHSTT.THHHHHHHHHHHHHHHHHC CS
        p450  35 pifrlklgs.kpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltptltsfgkl.sleelveeeaedlveklrk 131
                 ++++++lg+  ++++ ++ ++++e+l+kk + +s+    +l++    +  +   + +n + w+k+R++ +p + s+  l ++  ++ ee +++++ +++
  EFC37529.1  90 KVVKIQLGTfSQIHISNDENLIREILVKKYKTVSK---GNLFEPVGIFGPNIFSADSNDPIWRKHRTLANPIFSSSSHLkNVFRVTLEECKKMIKFWKS 185
                 68889999867788888999*********766555...467776443445555555555*****************77789****************** PP

                 CCCHCS.....EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHHHHHCHHHH CS
        p450 132 kagess.....elditellskaaldvigsilFgarfdlledeklselvkaveelssllskssvq 190
                   g+ s     +++i++ l  ++ldvi++++F   ++ + d+++   +   + +++ll+   ++
  EFC37529.1 186 IYGSESdgtirKVNISNELKSITLDVINRVAFDYDVG-IFDKDAAHRDGIHDWINNLLNGLIYN 248
                 99999999*****************************.77777666666666666666544444 PP

  == domain 2  score: 129.7 bits;  conditional E-value: 7.3e-42
                 SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCCTTTT-HHHHC.CT-HHHHHHHHHHHHHSCSSTTEEEEESSS..CEEET CS
        p450 258 lsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlgdkreptyddl.qklpyldavikEtLRlhpvvplllpRevtk..dvvir 353
                 ls+ el   ++ +lfaG++T+s+ l+++L  Lak++++qe++ +Ei++ + + + +t++ + +klp+l+ +ikE+LR  +++  +  R v+k    vi+
  EFC37529.1 256 LSKSELLSAIFIVLFAGFETSSTSLTFMLRMLAKDQKLQEEILKEINQEIDNIDDITFEIItNKLPLLTSFIKEVLRTKTPIG-TGGRIVLKknGEVIG 353
                 78999*********************************************9999*****87468*******************.778999986677999 PP

                 TEEE-TT-EEEEEHHHHHT-TTTS.SST.TS--GGGGB-TTS..........................CTESSCTT--TTEEGGGS-TTHHHHHHHHHH CS
        p450 354 gylipkGtevivnlyalhrdpevf.pnP.eeFdpeRFldekg..........................nskrksfaflPFGaGpRnCiGerlArmelkl 424
                 g++ pk+t++ v+ y+ h+    f +n  +eF+p RFl +k                             +   ++ lPF+ GpR CiG+r+A +e+kl
  EFC37529.1 354 GVHYPKDTHIGVSYYSQHY----FaKNGlDEFNPYRFLTTKSdsssneleksdnnefendgkgpmgelSINLATDKLLPFSIGPRDCIGKRMALLEMKL 448
                 9***************998....7433348***********9**************************5569*************************** PP

                 HHHHHHHHEEEEESTSTSGGE CS
        p450 425 flatlLqnFevelqpetdppp 445
                 +l+ lL+n++++++++ + ++
  EFC37529.1 449 ILVFLLKNYKLKVPKGLETQQ 469
                 *************87655544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (494 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       990  (0.0552178); expected 358.6 (0.02)
Passed bias filter:                      588  (0.032796); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.48
# Mc/sec: 3080.34
//
Query:       EFC37530.1  [L=482]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.3e-53  181.5   0.0    5.4e-53  180.3   0.0    1.7  1  PhzC-PhzF    Phenazine biosynthesis-like protein


Domain annotation for each model (and alignments):
>> PhzC-PhzF  Phenazine biosynthesis-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  180.3   0.0     3e-57   5.4e-53       1     239 [.       6     222 ..       6     261 .. 0.84

  Alignments for each domain:
  == domain 1  score: 180.3 bits;  conditional E-value: 3e-57
                 EEET-SSTTSSEEEEEEESTTCS-HHHHHHHHHHHTSSEEEEEE--SSTTSSEEEEEE-SSSEES--HHHHHHHHHHHHHHCT-S-SCEEEEEETTEEE CS
   PhzC-PhzF   1 vdaFtespfkGNpaaVvldadelddeelqsiAaelnlseTaFllkpsdekarfrlRyFTPvaEvdlcGHatlasahalaekglvasaetveletkaGil 99 
                 vdaFte+ f+GNpaaV++ ++ ++de +q+iAae nlseTaF +k+  +++ + lR+FTP++E+dlcGHatla+a ++ ++    + + ++++t +G+l
  EFC37530.1   6 VDAFTENIFEGNPAAVCVMKNWISDELMQKIAAENNLSETAFTVKE--DDGSYHLRWFTPLSEIDLCGHATLATAFVINNFYDS-EVKILKFKTMSGEL 101
                 8********************************************7..78****************************999986.999*********** PP

                 EE.EEEEETCEECCEEEEE-SEEEEEE-HHHHHHHHHHCCTSGG-TTS-BEEEESSSEEEEEEBSTCCHHHH----HHHHHHHCT-EEEEEEEETTTSS CS
   PhzC-PhzF 100 pvkslkekddgeellielkfPvikteevssedlallakllklaaqkalpiavkstglekvivplsseeavaelspdlaeeikkcpkkgvivtaaaeags 198
                  v        ++e l e++fP   +  +  +      + l +a  + +pi++  +  ++++++l++ee+v ++ p++  ++ ++p+ +   + + ++++
  EFC37530.1 102 VV-------VKKEDLFEMDFPSRMPTPFTIS------EQLIDA-LGITPIEAHIS--RDLVLVLENEEQVLNATPNF-SKLREIPDGLG--VLITSKSE 181
                 *9.......5778899*****8877665443......333344.45667777776..99******************.88888887655..56677889 PP

                 CCEEEEEEEEGGGTEEEESS-HHHHHHHHHHHHHCC-SSSE CS
   PhzC-PhzF 199 kkdfhsRmFaPklGivEDpvtGsAsgaLaaylseklnlees 239
                 k+df sR F+Pkl+++EDpv+GsA+ ++  y+s+ l ++e 
  EFC37530.1 182 KYDFVSRCFFPKLNVNEDPVCGSAHTSFIPYWSNILGKKEM 222
                 9********************************99988332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (482 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1519  (0.0847231); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 2851.45
//
Query:       EFC37531.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       732  (0.0408277); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1807.58
//
Query:       EFC37532.1  [L=746]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-31  109.2   0.0    2.9e-31  108.6   0.0    1.3  1  Peptidase_S9   Prolyl oligopeptidase family
    1.4e-08   34.7   0.5    2.2e-07   30.8   0.6    2.4  2  Abhydrolase_1  alpha/beta hydrolase fold
    1.2e-07   31.3   0.1    3.5e-05   23.2   0.0    2.2  2  Hydrolase_4    Serine aminopeptidase, S33
  ------ inclusion threshold ------
      0.014   15.3   0.0      0.023   14.6   0.0    1.4  1  Abhydrolase_3  alpha/beta hydrolase fold


Domain annotation for each model (and alignments):
>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.6   0.0   6.4e-35   2.9e-31       5     208 ..     530     744 ..     526     746 .] 0.90

  Alignments for each domain:
  == domain 1  score: 108.6 bits;  conditional E-value: 6.4e-35
                   HHHHHHHCCT-EEEEE--TTSSTTHCHHHHTTSGGGGHHHHHHHHHHHHHHHHTT..S--GGGEEEEEETHHHHHHHHHHHH-GGG-SEEEEESE-- CS
  Peptidase_S9   5 selqlladrGyvvvvanirGsggyGeafhdagkrklgqnefdDfiaaaealakeg..yvdserlaitGgSyGGyltgaalnqrpdlFkaavaevpvv 99 
                    ++ ++a  Gy+v+  n+rGs g++++f+  + ++ g+ +++D+ +  +++ +e+   vd++ + ++GgS GG+l+g +++q p+ Fka++  +pv+
    EFC37532.1 530 ARFIYFALCGYAVLLLNYRGSVGFSQSFAGCLPGNIGDMDVKDCYNSYRYILDENviPVDENSVSVYGGSHGGFLSGHLVGQYPSQFKAGILLNPVI 626
                   677788899**********************************************8779************************************** PP

                   -CCCHHCSTTS........THH.HCCCC--TTTCHHHHHHHHHH-CGGG-----EEEEEEETT-SSS-THHHHHHHHHHH..--S-SEEEEEETTS- CS
  Peptidase_S9 100 dvlrydsdtdl........lte.eymewgnpeeneegykelspyspldnvkaypplLlihGlaDdrvppaealklvaaLq..kkgknvlllifpdeg 185
                   ++ +  s++d+        l++  y+e    +e  +++ ++sp++++ n  +++++Ll++G+ D rvp +++ ++++ L+   k k++++l++p+ +
    EFC37532.1 627 NLATIFSESDIpdwcynesLGNdYYDEACVTKEMLTQMYDRSPIAHVSN--VTAAVLLLVGEVDRRVPKEQPREFYHSLRllGKCKEARMLVYPEND 721
                   ***********99997777677566676666666666669999999999..*****************************6555566********** PP

                   SSTTSSHHHHHHHHHHHHHHHHH CS
  Peptidase_S9 186 HgvgkprakveelarllaFlkea 208
                   H ++kp++  +   + + Fl ++
    EFC37532.1 722 HPIAKPKDDFDSMVSSALFLYKH 744
                   *******9988887777777666 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   0.6   4.8e-11   2.2e-07       2     137 ..     512     655 ..     511     669 .. 0.76
   2 ?    1.0   0.0     0.061   2.7e+02     203     252 ..     664     724 ..     657     728 .. 0.83

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 4.8e-11
                    EEEEE-STTT..CGGGGTTGHHHHHHHHTTSEEEEEEETT.STTSSSTTTGB.CHHSHHHHHHHHH...HHHHHC....TTSSEEEEEETHHHHHH CS
  Abhydrolase_1   2 vlvilhGlpg..ssdvwaerglapaLakdgfdvillDlrG.vgySspapacinddygtasvaddld...rildal....gddkltlvGhSmGGmia 87 
                    +l+i hG+p   +s ++a+   + ++a +g+ v+ll+ rG vg+S+    c + + g+++v d+++   +ild      +  ++ + G+S GG+++
     EFC37532.1 512 LLLIPHGGPHgsCSTIFAA--RFIYFALCGYAVLLLNYRGsVGFSQSFAGCLPGNIGDMDVKDCYNsyrYILDENvipvDENSVSVYGGSHGGFLS 605
                    59********777777888..55567778***********669999999999977777777777777668866541111445666*********** PP

                    HHHHHHHGGGEEEEEEESECSSCCHHHHHHHHHHHHHHCHHCHHHHHHHH CS
  Abhydrolase_1  88 layaaeyperVkalvllgaidpaaslieaqrqqaksfpdffdgyaadcar 137
                     ++  +yp+  ka +ll+++ + a + ++ +  ++ + + + ++++d+a 
     EFC37532.1 606 GHLVGQYPSQFKAGILLNPVINLATIFSESDIPDWCYNESLGNDYYDEAC 655
                    *******************7777777777777777777777777777665 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.061
                    HHHC.....THHHHSEEEEEEETTCSSSCH.HHHHHHHHC.....HTSEEEEEEETCSSSH CS
  Abhydrolase_1 203 rlre.....lknvlaptlvisgtsDplvpp.kaledlaql.....lpkkrlvvisdagHla 252
                    ++++     ++nv+a +l++ g+ D+ vp  +  e++ +l     ++++r +v++   H +
     EFC37532.1 664 MYDRspiahVSNVTAAVLLLVGEVDRRVPKeQPREFYHSLrllgkCKEARMLVYPENDHPI 724
                    45556778899*******************8888888888988877779999999988865 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.0   7.7e-09   3.5e-05       6     115 ..     512     630 ..     507     648 .. 0.84
   2 !    6.0   0.0    0.0014       6.4     186     219 ..     672     705 ..     644     727 .. 0.77

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 7.7e-09
  Hydrolase_4   6 vvvlvHGl..aehsgryaelaeaLaaqGfavyalDhrGh.Grse.......gkrghvpsfddyvdDlaafvekvkeehpelplfllGhSmGGlially 93 
                  ++++ HG   ++ s  +a  + ++a +G+av+ l++rG  G s+       g+ g++ +++d+++  + ++++ + +  e  + ++G S GG+++ ++
   EFC37532.1 512 LLLIPHGGphGSCSTIFAARFIYFALCGYAVLLLNYRGSvGFSQsfagclpGNIGDM-DVKDCYNSYRYILDENVIPVDENSVSVYGGSHGGFLSGHL 608
                  5667777433778889999999****************5599999999887777765.578888888888888888888889**************** PP

  Hydrolase_4  94 llrypdkvaglilsaPalkika 115
                  + +yp+++++ il +P++++++
   EFC37532.1 609 VGQYPSQFKAGILLNPVINLAT 630
                  *****************98875 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0014
  Hydrolase_4 186 raakitlPllllhGeaDkvvdpeasrelyerlgs 219
                  +++++t+ +lll Ge D+ v++e+ re+y +l+ 
   EFC37532.1 672 HVSNVTAAVLLLVGEVDRRVPKEQPREFYHSLRL 705
                  6678999**********************98864 PP

>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   5.1e-06     0.023      49     115 ..     570     635 ..     562     725 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 5.1e-06
                    HHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHHHHHHHHHHHHHTT---EEEEEEESE-SST....SST CS
  Abhydrolase_3  49 vedalaalrwlaeqawelgadpsrivlaGdSaGGnlaaavalrardegepkvagqvliyPvtdl....ert 115
                    v+d+++++r++++++  + +d++++ + G S GG l+ +++ +  ++     ++ +l+ Pv +l    +++
     EFC37532.1 570 VKDCYNSYRYILDEN-VIPVDENSVSVYGGSHGGFLSGHLVGQYPSQ----FKAGILLNPVINLatifSES 635
                    89***********95.789*********************9777775....88999999966552222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (746 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       436  (0.0243181); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 4539.81
//
Query:       EFC37533.1  [L=1740]
Description: kinesin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.3e-45  153.6   3.0    6.3e-45  153.6   3.0    4.1  4  Pkinase         Protein kinase domain
    9.7e-26   90.6   6.7      2e-20   73.2   0.5    4.3  4  Pkinase_Tyr     Protein tyrosine kinase
    2.8e-18   65.9   0.1    2.8e-18   65.9   0.1    3.6  3  Kinesin         Kinesin motor domain
    8.2e-14   51.5   0.2    2.7e-13   49.8   0.2    2.0  1  SAM_2           SAM domain (Sterile alpha motif)
    2.3e-13   50.4   1.4      2e-12   47.3   0.2    2.9  3  SAM_1           SAM domain (Sterile alpha motif)
    5.5e-07   29.6   0.1    3.7e-06   27.0   0.1    2.6  1  Microtub_bd     Microtubule binding
     0.0029   17.5   0.3     0.0088   16.0   0.3    1.9  1  SAM_PNT         Sterile alpha motif (SAM)/Pointed domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1     0.038        97      73     139 ..     830     900 ..     796     903 .. 0.74
   2 ?   -1.4   0.0      0.46   1.2e+03     242     261 ..     950     969 ..     942     971 .. 0.92
   3 ?   -3.7   0.2       2.3   5.9e+03     182     228 ..    1064    1112 ..    1064    1122 .. 0.46
   4 !  153.6   3.0   2.5e-48   6.3e-45       1     258 [.    1149    1477 ..    1149    1479 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.038
                 EEEEEE--TTEBHHHHHH....HHSS--HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEE.TTTEEEE CS
     Pkinase  73 lylvleyveggeladlle....rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLid.ekgelKi 139
                 +y+++e +    + ++++    +++++s   + ++++q+  gl+ +H + + +H  +  + i+++  ++ +Ki
  EFC37533.1 830 FYIFVEPCL--LMYKIIQktkiEEKKFSYPILLEWLSQLSDGLANIHeQLETVHGNIDVNSIFFSkLEESMKI 900
                 556666655..23444443334556666668899*************55679**9999999999944555887 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.46
                 HHHT-SSGCCSTTHHHHHTS CS
     Pkinase 242 kkllkkdpkkRltaeellqh 261
                 ++++++dp+ R+ ++el+q+
  EFC37533.1 950 DRCCHYDPSCRPNMRELCQQ 969
                 58**************9985 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 2.3
                  HHHHHHHHHHHSS-STTTSSHHHHHHHHHHT..HHHHHHHCT.SHH...H CS
     Pkinase  182 slGvilyelltgkppfsgekgkekvekeldq..lekilkilg.etkeklp 228 
                  s+G +++  ++++   +++k+k+  +  +++  l+ki++i + e+++   
  EFC37533.1 1064 SIGRTIMRYVNKHYKIKDKKKKK-LKLATMKtkLMKIAHIQEtEVDNRRS 1112
                  56667777777777777444444.33333331344444444432233333 PP

  == domain 4  score: 153.6 bits;  conditional E-value: 2.5e-48
                  EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE........................... CS
     Pkinase    1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee........................... 69  
                  y+ ++ +G+Gs G+V+ka+++++++ vA+K+i+ +++++++   + +Ei+ + +l+  +ni+++y++f                             
  EFC37533.1 1149 YSIISVIGSGSQGTVIKAFDSQNNRFVAIKRIRMKDNNDTML--ASKEISAMFSLNdNDNICKIYNWFIYcenredkkiitsenlsdsedehdfdee 1243
                  667899******************************999887..9***********9**********999999************************ PP

                  ...............SSEEE..EEEE--TTEBHHHHHH....HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET...........T CS
     Pkinase   70 ...............kdely..lvleyveggeladlle....rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide...........k 134 
                                 +   y  +v+ey+++g+l ++++     ++ ++++++kk++++++ + +y+H+++++HrD+ ++Ni++++            
  EFC37533.1 1244 ddeedeydfkdyaneTW--YigIVMEYCSEGDLRKAMRycreCNTYFKNSTVKKWLNELICATDYIHRRNLMHRDISTKNIFLHSntelqpsstliG 1338
                  ***********996334..346**************9999755666**************************************6355555555550 PP

                  TE.........EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTS CS
     Pkinase  135 ge.........lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilge 222 
                             +Ki+D Gl+ +le+ ++ +s  gt++++APE   +++y+++vD+WslG+i +e++ +       k+++++ ++ ++ ++ ++  +e
  EFC37533.1 1339 -TppsyfdachVKIGDMGLSIKLEELNRNNSAWGTRRWMAPEQRLGKRYDSTVDIWSLGCIALEMVLQYSYSMVVKSSNSMDNMDHD-MRHVDYYQE 1433
                  .0555556666********************************99*********************998877655555554444444.333333334 PP

                  HH...HHHTTS........-HHHHHHHHHHT-SSGCCSTTHHHH CS
     Pkinase  223 tkeklpeasei........seeakdllkkllkkdpkkRltaeel 258 
                   k++ +  ++i        ++++++++kk+l  +p kR  a++l
  EFC37533.1 1434 IKNNPNFLNDIlrplesyyDDNIIEFIKKCLVIEPWKRAKAQQL 1477
                  4444444444455556666*********************9997 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.029        74      95     147 ..     847     903 ..     753     918 .. 0.77
   2 ?    0.5   0.2      0.12   3.1e+02     240     259 .]     951     970 ..     949     970 .. 0.93
   3 !   14.1   0.0     8e-06     0.021       3      78 ..    1151    1225 ..    1149    1232 .. 0.79
   4 !   73.2   0.5   7.9e-24     2e-20      76     256 ..    1262    1478 ..    1252    1481 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.029
                  T..CTTTSBHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE.TTEEEE-ST CS
  Pkinase_Tyr  95 k..ekekltlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse.nkvvkisDf 147
                  +  e++k+++  ll++  q+++G++ ++++ + vH ++    ++ s+ ++ +ki+  
   EFC37533.1 847 TkiEEKKFSYPILLEWLSQLSDGLANIHEQlETVHGNIDVNSIFFSKlEESMKIGNM 903
                  25678999******************998747*********9999985668888765 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.12
                  HHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 240 kcweedpeeRptfselvekl 259
                  +c ++dp+ Rp+++el ++l
   EFC37533.1 951 RCCHYDPSCRPNMRELCQQL 970
                  7***************9986 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 8e-06
                   EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE...SSSSEEE CS
  Pkinase_Tyr    3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvct...keeplli 78  
                   + + +G+G+ G+V+++  +    +++  Va+K ++ + +++ +    +e++ m +l +++ni k++ + +   ++e   i
   EFC37533.1 1151 IISVIGSGSQGTVIKAFDS----QNNRFVAIKRIRMKDNND-TMLASKEISAMFSLnDNDNICKIYNWFIyceNREDKKI 1225
                   5678***********9877....9999*******7766666.555667********99******9987664434444444 PP

  == domain 4  score: 73.2 bits;  conditional E-value: 7.9e-24
                   EEEEEE--TTEBHHHHHHHT..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE...................TTEEEE-STTTH CS
  Pkinase_Tyr   76 llivteyvkgGdLlkfLrkk..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse...................nkvvkisDfGLa 150 
                   + iv+ey+++GdL+k +r     ++ ++ +++ ++  ++ ++ +y+++++l+Hrd++++N++l++                     +vki+D GL+
   EFC37533.1 1262 IGIVMEYCSEGDLRKAMRYCreCNTYFKNSTVKKWLNELICATDYIHRRNLMHRDISTKNIFLHSntelqpsstligtppsyfdACHVKIGDMGLS 1357
                   679************9997622466778888999******************************99*****************888********** PP

                   EETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGT............TTTSHHHHHHHHHHTTEE......S-BBT CS
  Pkinase_Tyr  151 rdiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgesp............ypglkneevleklkegkr......lekpe 228 
                    ++   +e +++++a    +WmapE    k++ s  D+Ws G +  E++ + + +             +++++ + ++ +k++ +       +  +
   EFC37533.1 1358 IKL---EELNRNNSAWGTRRWMAPEQRLGKRYDSTVDIWSLGCIALEMVLQYSYSmvvkssnsmdnmDHDMRHVDYYQEIKNNPNflndilRPLES 1450
                   ***...7888889999999****************************9875554456677777666644444445666665554422221123345 PP

                   TSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr  229 kcpeelyelmkkcweedpeeRptfselv 256 
                   +  +++ e++kkc+  +p +R++ ++l 
   EFC37533.1 1451 YYDDNIIEFIKKCLVIEPWKRAKAQQLY 1478
                   6788899999999999999998888875 PP

>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.9   0.1   1.1e-21   2.8e-18      23     189 ..      43     202 ..       9     241 .. 0.85
   2 ?    0.3   0.2       0.1   2.6e+02      96     147 ..     743     793 ..     725     830 .. 0.79
   3 ?   -3.3   1.0       1.3   3.4e+03     148     188 ..    1081    1120 ..    1073    1130 .. 0.78

  Alignments for each domain:
  == domain 1  score: 65.9 bits;  conditional E-value: 1.1e-21
                 TCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHTTSEEEEEEEESTTSSHHHHHTBCTTTSBSHHHHHHHHHHHHHHHCTTTH CS
     Kinesin  23 ekkeeekkskkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvleGynatifaYGqtgsGKTyTmegkeeeeeGiipraleelFesikkekeek 121
                 +++ e+ +  ++n +e+ k+f+ ++++d++atq +++ + + pl+e++++ + + ++ +G   +GK +++eg   e +G  +r++e lF++i+ e  + 
  EFC37533.1  43 ATDLEHFTVYENNVRENGKTFECKHIYDSSATQFDIFANEVVPLIEKCFQAQDCAVLYFGSDFAGKRFSLEGL-PEYPGFFYRTIELLFDTIAGEDPS- 139
                 66777778888999999*******************************************************8.999***************997766. PP

                 EEEEEEEEEEEEEETTEEEETTSTTTTSTSSEBEEEECTTSCCEEETTS--EEESSHHHHHHHHHHHH CS
     Kinesin 122 ekefsvkvsylEiYneeiyDLLeskkskkkkklkiredskkgevyvkgltevevksaeevlellekge 189
                  +++++  s + i +e+i+D L s+   +++++k+r+d+kkg ++ +g t +e+ +++++l++  ++ 
  EFC37533.1 140 -NKCRLFYSSFTIEKETIFDNLPSD---SSSQIKLRDDKKKG-IIAEGGTLIELYDIQQALQVYYEST 202
                 .89*******************999...45569*******98.**************99999876655 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.1
                 TTTSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEEEEEETTEEEETTSTTT CS
     Kinesin  96 eeeeeGiipraleelFesikkekeekekefsvkvsylEiYneeiyDLLeskk 147
                 +e+e+Gi+ + + +  ++i++ek +   +  v+ +++E Y e+   LL  ++
  EFC37533.1 743 PENESGITDKYFYDGINTITNEKVN-VISQLVSAEFVETYRERSKKLLLIDN 793
                 5678999999999999999888877.889999***********999997664 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 1.3
                  TSTSSEBEEEECTTSCCEEETTS--EEESSHHHHHHHHHHH CS
     Kinesin  148 skkkkklkiredskkgevyvkgltevevksaeevlellekg 188 
                  +kkkkklk+   ++k  ++++ ++e+ev++ +   ++le+ 
  EFC37533.1 1081 DKKKKKLKLATMKTKL-MKIAHIQETEVDNRRSSKKTLEEE 1120
                  4667789999988865.999999999999998888888765 PP

>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.8   0.2   1.1e-16   2.7e-13       4      66 .]    1670    1731 ..    1667    1731 .. 0.98

  Alignments for each domain:
  == domain 1  score: 49.8 bits;  conditional E-value: 1.1e-16
                  HHHHHHHHHHHHTTTGGGHHHHHHTTCSHHHHHTTSCHHHHHHTTHHHHHHHHHHHHHHHHHH CS
       SAM_2    4 wsledvaeWLrsiglkqytdnFrdagitgaelllrlteedLkrlGitsvghrkkilkkiqelk 66  
                  w+++dv+ WL si++ ++++nF +++itg ++ll + eed+k+ G+ ++g+ + +++ iq+l+
  EFC37533.1 1670 WTTNDVGIWLISIDFSKFVENFQSQNITG-RALLLIREEDMKDVGVVKLGDKLLLWNMIQNLR 1731
                  *****************************.*******************************96 PP

>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.58   1.5e+03      13      35 ..    1119    1142 ..    1117    1145 .. 0.89
   2 ?   -2.1   0.0       2.1   5.5e+03       6      20 ..    1291    1306 ..    1289    1314 .. 0.80
   3 !   47.3   0.2   7.9e-16     2e-12       1      64 []    1668    1731 ..    1668    1731 .. 0.97

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.58
                  HHTTSGGGHHHH.HTTTSSHHHHT CS
       SAM_1   13 esiglgqYadlF.rageidgdaLl 35  
                  e+++l  ++  F  ++e+d++ L+
  EFC37533.1 1119 EELKLRNHTRVFeHQEEVDLKILQ 1142
                  568999**************9885 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2.1
                  SSHHHHHHHTTS.GGG CS
       SAM_1    6 edVgeWLesigl.gqY 20  
                  ++V  WL+++ +  +Y
  EFC37533.1 1291 STVKKWLNELICaTDY 1306
                  7899****99874555 PP

  == domain 3  score: 47.3 bits;  conditional E-value: 7.9e-16
                  CCTTHSSHHHHHHHTTSGGGHHHHHTTTSSHHHHTTSCHHHHHHCTTTSHHHHHHHHHHHHHHH CS
       SAM_1    1 skwsvedVgeWLesiglgqYadlFrageidgdaLlllteddLeklgvtllGHrkkIlyaIqrLk 64  
                  s w+ +dVg WL si++++ +++F+++ i+g+aLll+ e+d++++gv +lG+ + + + Iq L+
  EFC37533.1 1668 SDWTTNDVGIWLISIDFSKFVENFQSQNITGRALLLIREEDMKDVGVVKLGDKLLLWNMIQNLR 1731
                  57**********************************************************9986 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.1   1.4e-09   3.7e-06      43     149 .]      48     160 ..      10     160 .. 0.86

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 1.4e-09
                  T.........TTTEEEE-SEEEECTTHCCCCC.CCCHHHHHHHHTT--EEEEEEES................ST-HCHHHHHHHHHHCCTSCCCCEEE CS
  Microtub_bd  43 e......eekkkkkefsFdrvfeseseqeevf.eeisqlvqsaldgynvcifaygqTGsGKtyTmegeeeeagmipraveeifetiselkekgwkyei 133
                  +      + +++ k+f+  ++++s+++q ++f +e+  l++ +++  ++ ++  g+  +GK + +eg  e +g   r++e +f+ti+ + + + k ++
   EFC37533.1  48 HftvyenNVRENGKTFECKHIYDSSATQFDIFaNEVVPLIEKCFQAQDCAVLYFGSDFAGKRFSLEGLPEYPGFFYRTIELLFDTIAGE-DPSNKCRL 144
                  033444488999**************998887479****************************************************99.78999999 PP

                  EEEEEEEESS-EEETT CS
  Microtub_bd 134 elqfveiynekvqDlL 149
                   ++   i+ e++ D L
   EFC37533.1 145 FYSSFTIEKETIFDNL 160
                  99999******99976 PP

>> SAM_PNT  Sterile alpha motif (SAM)/Pointed domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.3   3.4e-06    0.0088      16      82 ..    1666    1732 ..    1645    1734 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 3.4e-06
                  SGGG--HHHHHHHHHHHHHHTT-SS-HGGGCTS-HHHHHHS-HHHHHHHSCHCCHHH..HHHHHHHHHH CS
     SAM_PNT   16 dPqeWtkehVlewlewavkefdlakidfsefdmsGkeLcsltkeefleaapllaGdi..LyehLqnlrk 82  
                    ++Wt+++V  wl      f+    +f+ +++ G++L+ + +e+++ +   + Gd+  L++++qnlr+
  EFC37533.1 1666 SISDWTTNDVGIWLIS--IDFSKFVENFQSQNITGRALLLIREEDMKDVGVVKLGDKllLWNMIQNLRQ 1732
                  5578*********953..3566667799999*****************999999996337*******96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1740 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2353  (0.13124); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        28  (0.00156172); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.40u 0.33s 00:00:01.73 Elapsed: 00:00:00.58
# Mc/sec: 9053.04
//
Query:       EFC37534.1  [L=936]
Description: structural maintenance of chromosome 3 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.2e-56  191.6  34.9    1.9e-56  191.0  34.9    1.3  1  SMC_N         RecF/RecN/SMC N terminal domain
    3.8e-19   70.0  11.8    3.8e-19   70.0  11.8    5.1  4  AAA_23        AAA domain
    3.9e-16   59.7   6.2    1.3e-08   35.0   0.5    3.5  3  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
    3.6e-15   56.3   0.0    1.2e-14   54.6   0.0    1.9  1  SMC_hinge     SMC proteins Flexible Hinge Domain
      7e-10   39.1   9.3      7e-10   39.1   9.3    3.5  3  AAA_15        AAA ATPase domain
    0.00078   19.1   0.0     0.0016   18.1   0.0    1.5  1  AAA_29        P-loop containing region of AAA domain
  ------ inclusion threshold ------
       0.01   15.4   0.1       0.01   15.4   0.1    4.1  5  AAA_27        AAA domain
       0.05   13.0   0.4       0.33   10.3   0.0    2.5  2  FtsK_SpoIIIE  FtsK/SpoIIIE family


Domain annotation for each model (and alignments):
>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  191.0  34.9   8.3e-60   1.9e-56       1     219 [.       2     894 ..       2     895 .. 0.99

  Alignments for each domain:
  == domain 1  score: 191.0 bits;  conditional E-value: 8.3e-60
                 EEEEEEEESETTEECEEE.EEETTSSEEEEEESTTSSHHHHHHHHHHHCTT.TTTTTTCHCCCCCC--BTTCSSTTEEEEEEEEEETTEESSSSSSCEE CS
                 xxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N   1 vlkrleienFksyagktv.ilpfsksftaivGpNGSGKsnlldAilFvLGersakklrseklsdlihkskekasvkkaeveitfdnedkklkiekeevs 98 
                 ++k+++i++Fksy+++t  + +fs s ++ivG+NGSGKsn++ Ai+FvL+e+  +klrse+ ++ +h+  +++ v +a vei+fdn+d++l+++++ev 
  EFC37534.1   2 HIKSVTIQGFKSYRDQTFtSQEFSASQNIIVGRNGSGKSNFFSAISFVLSEK-FSKLRSEERQAFLHE-GTGRGVISAFVEIVFDNSDNRLPTDSKEVA 98 
                 589***********99862579****************************75.55************9.9***************************** PP

                 EEEEEETTSEEEEEETTEEE-HHHHHHHHHCTT-STT.............................................................. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.............................................................. RF
       SMC_N  99 isrrvkrkgeseykingkevtkkevsellesagiske.............................................................. 135
                 i+r++  k++ ey+i+gk vt++ev +llesag+s++                                                              
  EFC37534.1  99 IRRTIGLKKD-EYRIDGKAVTQREVFNLLESAGLSSSnpyyiveqgkvsslttmkdaerlellkeiagtkvydqkraesltimkdteqkkqkideviey 196
                 *********9.**************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37534.1 197 vqgrldeleqekeelkefqkldkdrrcveyaifeqelseatknleeiekaretvevtagnslyhvvvenekvsgdiikimnesnapgrvtfiplnrlka 295
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37534.1 296 ldsddsigtsefiplwkkidadskfnevvkslfgktfctktledgaqfakdhnvncvtlagdqanrkgtltggyieqkqsrldcwkqikdlrktysesf 394
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37534.1 395 dkskkikasiatleeqlnscitdlhkvesevhnskntiqyeqqeihnltvrrdlikdnlrsneellekvksilssnketiesytkekdlpldatlnsre 493
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37534.1 494 kqeleklsksvtelttklqgvsknrleketkkeslriqlttnyiprkselqvlietlptdnsissshqtlmqlqtekqvteerikdttesvkrldqeid 592
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37534.1 593 elgetirnkqeqletekseetkklqtlqekasslekllnkkkiwsqkkeecikqikelgtlpsdfrkyletdqklllkklhntneklkkfghvnkkald 691
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC37534.1 692 qyeqfsnqkeeflekkseldssakaineliqvldkrkdeaivrtfkqvqknfqeifqnlvpgghaslsmkyrngedeeeeeeedeeakeveqyagvsik 790
                 *************************************************************************************************** PP

                 ...................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHH..HHCTTSEEEEE-SSHHHCCC-SCEEEEEE CS
                 ...................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 ...................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellk..eksknaQfivislreemlekadklvgvtk 213
                                    +LSgG+k+Lval L+fAiq+++pap+yl+DeidaaLD ++++ va++++  +++++ Qfi  +++ e+le a++++g+++
  EFC37534.1 791 vsfmssgdseedqsyhlmqQLSGGQKSLVALCLIFAIQRCDPAPFYLFDEIDAALDPAYRTSVANMIDtlSTKEKIQFITATFKPEVLETAENFYGISF 889
                 ********************************************************************4445567***********************9 PP

                 EETTEE CS
                 xxxxxx RF
       SMC_N 214 vengvs 219
                  +n+vs
  EFC37534.1 890 -KNKVS 894
                 .66655 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.0  11.8   1.7e-22   3.8e-19       1     190 [.       5     245 ..       5     252 .. 0.62
   2 ?   -5.7  24.6         8   1.8e+04      57     176 ..     403     518 ..     318     537 .. 0.46
   3 ?   -7.5  27.8         8   1.8e+04      96     197 ..     522     628 ..     513     650 .. 0.48
   4 ?  -13.5  28.9         8   1.8e+04      90     176 ..     647     766 ..     626     785 .. 0.43

  Alignments for each domain:
  == domain 1  score: 70.0 bits;  conditional E-value: 1.7e-22
      AAA_23   1 kLkienfrsfrdqei...dFskgltlItGpNGaGKTTildAiklaLygetprlsrksgrgfeksdveiesegkvkayveltfenkdgry.........t 87 
                 +++i++f+s+rdq++   +Fs   ++I+G NG+GK+ ++ Ai ++L +++++l++++++ f ++      +g  +a+ve+ f n d+r           
  EFC37534.1   5 SVTIQGFKSYRDQTFtsqEFSASQNIIVGRNGSGKSNFFSAISFVLSEKFSKLRSEERQAFLHEGT---GRGVISAFVEIVFDNSDNRLptdskevaiR 100
                 689***********988899**********************************986655555554...478999************988776644442 PP

      AAA_23  88 rsiererelskkkgktt.kkaklelleideleqfisellgskkiilnlilflgqer........................feefelkdkke........ 153
                 r+i  ++ +++ +gk + + + ++lle + l    + ++  + + ++l  ++++er                        +   ++++kk+        
  EFC37534.1 101 RTIGLKKDEYRIDGKAVtQREVFNLLESAGLSSSNPYYIVEQGKVSSLTTMKDAERlellkeiagtkvydqkraesltimK---DTEQKKQkideviey 196
                 222222222222222221344455555555555555588888889999999999996666666666566555444442221...113333344455555 PP

      AAA_23 154 ...rleelekeleeledekkllekl.........eqekekekeleelee 190
                    rl+ele+e+eel++++kl +++         +++ e  k+lee+e+
  EFC37534.1 197 vqgRLDELEQEKEELKEFQKLDKDRrcveyaifeQELSEATKNLEEIEK 245
                 5555555555555555555433333555555554333344444444444 PP

  == domain 2  score: -5.7 bits;  conditional E-value: 8
      AAA_23  57 gfeksdveiesegkvkayveltfenkdgrytrsiererelskkkgkttkkaklelleideleqfisellgskkiilnlilflgqer..feefelkdkke 153
                 ++ + +  ++s  ++   ve ++ n +     +i++e++++ + +++++  k +l + +el ++++++l+s+k+ ++ +   ++++   +  +++++k+
  EFC37534.1 403 SIATLEEQLNSCITDLHKVESEVHNSK----NTIQYEQQEIHNLTVRRDLIKDNLRSNEELLEKVKSILSSNKETIESYT--KEKDlpLDATLNSREKQ 495
                 111111111111222222222222222....2344444444444444444444444444444444444444444333222..22222233344455555 PP

      AAA_23 154 rleelekeleeledekkllekle 176
                 +le+l+k+  el+++ + + k+ 
  EFC37534.1 496 ELEKLSKSVTELTTKLQGVSKNR 518
                 55555555555555555555543 PP

  == domain 3  score: -7.5 bits;  conditional E-value: 8
      AAA_23  96 lskkkgkttkkaklelleideleqfisellgskkiil.nlilflgqer..feefelkdkkerleelekeleeledekkllekl.e.qekekekeleele 189
                 ++kk++ +++ ++  + +++el+ +i++l + + i++ ++ l++ q +    e++ kd+ e ++ l +e++el ++++  +++ e ++ e+ k+l++l+
  EFC37534.1 522 ETKKESLRIQLTTNYIPRKSELQVLIETLPTDNSISSsHQTLMQLQTEkqVTEERIKDTTESVKRLDQEIDELGETIRNKQEQlEtEKSEETKKLQTLQ 620
                 333444444555555555677777777644444443323333322222112223336677777777777777655444333332312233334555555 PP

      AAA_23 190 eeleeilk 197
                 e+  +++k
  EFC37534.1 621 EKASSLEK 628
                 54444443 PP

  == domain 4  score: -13.5 bits;  conditional E-value: 8
      AAA_23  90 iererelskkkgkttkkaklellei.deleqfisellgskkiilnlilflgqerfeefelkdkkerleelekeleeledekkllekl............ 175
                 i++  +l ++  k+   +++ ll++  ++++++++  +++k+ l+++  +  +++   e  +kk++l++  k+++el ++ ++ +++            
  EFC37534.1 647 IKELGTLPSDFRKYLETDQKLLLKKlHNTNEKLKKFGHVNKKALDQYEQFSNQKE---EFLEKKSELDSSAKAINELIQVLDKRKDEaivrtfkqvqkn 742
                 2222222223333333333333333333344444444444444433333333332...33344555555555555555555555555555555544555 PP

      AAA_23 176 .......................e 176
                                        e
  EFC37534.1 743 fqeifqnlvpgghaslsmkyrngE 766
                 555555556666666555555552 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.0   3.8e-09   8.5e-06       2      26 ..      29      60 ..      29     123 .. 0.77
   2 ?   -1.4   0.1      0.73   1.6e+03     126     210 ..     397     487 ..     361     563 .. 0.53
   3 !   35.0   0.5   5.8e-12   1.3e-08      77     296 ..     662     872 ..     633     879 .. 0.67

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 3.8e-09
      AAA_21  2 nvliGpNgsGKSnLLdaldllarl.......d 26
                n+++G+NgsGKSn++ a++++ +         
  EFC37534.1 29 NIIVGRNGSGKSNFFSAISFVLSEkfsklrsE 60
                89******************987544444330 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.73
      AAA_21 126 slkelsvsepndlqfgkaltditsrawsllllldglrke......rigllnifadyfgfakekrllqrlvrslklveielsdlgegeelia 210
                 s k +  +   ++q ++ +td+ +  ++   +++ + +e         + ++ +d++  ++e+    + + s+++  ie ++ ++  +l a
  EFC37534.1 397 SKKIKASIATLEEQLNSCITDLHKVESEVHNSKNTIQYEqqeihnLTVRRDLIKDNLRSNEELLEKVKSILSSNKETIESYTKEKDLPLDA 487
                 4444444444444444444444444444333333333333333333333333333333333333333333333333333333333333333 PP

  == domain 3  score: 35.0 bits;  conditional E-value: 5.8e-12
      AAA_21  77 rlersqveeklssvetllesgllldkrsleeedvfnpeargirggvsvfslkelsvsepndlqfgkaltditsrawsllllldglrkerigllnifady 175
                 + +++ +  kl + +++l+++  ++k++l+++ +f+++++++ + +s+  + ++ ++e +    ++    i++++ +           ++++++if+++
  EFC37534.1 662 ETDQKLLLKKLHNTNEKLKKFGHVNKKALDQYEQFSNQKEEFLEKKSELDSSAKAINELIQVLDKRKDEAIVRTFKQV----------QKNFQEIFQNL 750
                 444444466666777777777777777777777777777777777777777777777666555555555555555543..........34444444444 PP

      AAA_21 176 fgfakekrllqrlvrslklveielsdlgegeeliasvderlrer....gvvflengdgqelparel....SdGtkrll..alltallralkkgsllliD 264
                 +++ +    ++ + ++  +           ee+ ++++e+++++     v f+  gd  e ++++l    S G+k+l   +l+ a+ r ++  +++l+D
  EFC37534.1 751 VPGGHASLSMKYRNGEDEEE---------EEEEDEEAKEVEQYAgvsiKVSFMSSGDSEEDQSYHLmqqlSGGQKSLValCLIFAIQRCDPA-PFYLFD 839
                 44444444444333333333.........33333334444444455668999999999999999999999*******634666666666666.****** PP

      AAA_21 265 EpEngLHPkllrrllellkelsr.ngaQviltT 296
                 E+++ L+P+  ++++ +++ ls+ +++Q+i +T
  EFC37534.1 840 EIDAALDPAYRTSVANMIDTLSTkEKIQFITAT 872
                 ******************66666699***9887 PP

>> SMC_hinge  SMC proteins Flexible Hinge Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.6   0.0   5.3e-18   1.2e-14      16     115 ..     244     342 ..     238     344 .. 0.93

  Alignments for each domain:
  == domain 1  score: 54.6 bits;  conditional E-value: 5.3e-18
   SMC_hinge  16 egyekAveaalgnrlqalvvedeetakkiieflkkk.nagratflpldrikqknkadgandknsgavplidlvevddelrkalryllgdtlvvdsldeA 113
                 e+++  ve+ +gn+l ++vve+e++   ii+ + +    gr+tf+pl+r+k   ++d+  ++     pl++ ++ d+++ ++++ l+g+t+  ++l+++
  EFC37534.1 244 EKARETVEVTAGNSLYHVVVENEKVSGDIIKIMNESnAPGRVTFIPLNRLKALDSDDSIGTS--EFIPLWKKIDADSKFNEVVKSLFGKTFCTKTLEDG 340
                 567788******************************779****************9999998..6********************************97 PP

   SMC_hinge 114 ee 115
                  +
  EFC37534.1 341 AQ 342
                 65 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1   9.3   3.1e-13     7e-10       1     226 [.       1     244 [.       1     323 [. 0.61
   2 ?   -0.4  22.9      0.33   7.4e+02     140     284 ..     382     544 ..     362     563 .. 0.77
   3 !    5.1  34.9    0.0072        16      72     363 ..     525     872 ..     521     878 .. 0.51

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 3.1e-13
      AAA_15   1 MkIkkikikNFRslkd...veidlseeltvliGkNnsGKSsilealdlFlnnkekkn.......................kkvikiekedleifenise 73 
                 M Ik+++i+ F+s++d   ++ ++s + ++++G+N+sGKS++  a+ + l++k  ++                       + +i+++++d +       
  EFC37534.1   1 MHIKSVTIQGFKSYRDqtfTSQEFSASQNIIVGRNGSGKSNFFSAISFVLSEK--FSklrseerqaflhegtgrgvisafV-EIVFDNSDNRLP---TD 93 
                 99**************5444455555599**********************88..44567888888999999999888742.344444444443...44 PP

      AAA_15  74 skdikIdvefaek.ekakeyektlkskekkkadlllk..kkesdlkktikdkklklkknelsdekisvekkkskkelpkekeeklekekeelkidkedl 169
                 sk++ I+ +     +k++++++ ++ ++++  +ll      +s  ++++++ k    ++ ++ e+ ++ k+ +  + ++ k+ ++ +  ++++ +k+++
  EFC37534.1  94 SKEVAIRRTI--GlKKDEYRIDGKAVTQREVFNLLESagLSSSNPYYIVEQGKVSSLTTMKDAERLELLKEIAGTKVYDQKRAESLTIMKDTEQKKQKI 190
                 5555555555..212333333444444444333332211233344455555555555555555555555555555555555555555555555555555 PP

      AAA_15 170 kklikkleeslkkee.elknvlksaiiklllisakRnvsdedsekkssllgklkekil 226
                 +++i+  +        el++  +++ +  +l++++R v+    e++ s  +k +e+i 
  EFC37534.1 191 DEVIEYVQGR----LdELEQEKEELKEFQKLDKDRRCVEYAIFEQELSEATKNLEEIE 244
                 5555522222....22333444444444445555554444444444444444444443 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.33
      AAA_15 140 kkkskkelpkekeeklekekeelkidkedlkklikkleeslkkeeelknvlksaiiklllisakRnvsdedsekkssllgklkekileealqekl.... 234
                 ++k+ ++ ++e+ +k++k k+++ +  e l++ i +l++  ++    kn ++ +++++     +R+  +++  ++++ll+k+k+ ++++  +e      
  EFC37534.1 382 QIKDLRKTYSESFDKSKKIKASIATLEEQLNSCITDLHKVESEVHNSKNTIQYEQQEIHNLTVRRDLIKDNLRSNEELLEKVKSILSSN--KETIesyt 478
                 34558889999999999999999999*********99999999999*************************************999997..34446899 PP

      AAA_15 235 ...........eeelteklkeiqeklkeidkklaeelk....kilkkkidkik.kfnykgkkneei 284
                            + + +++l+++ ++++e+  kl+   k    k+ kk    i+  +ny + k+e+ 
  EFC37534.1 479 kekdlpldatlNSREKQELEKLSKSVTELTTKLQGVSKnrleKETKKESLRIQlTTNYIPRKSELQ 544
                 99999******7777888888888888888888777774444444444444454666666666554 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0072
      AAA_15  72 seskdikIdvef...............................aekekakeyektlkskekkkadlllkkkesdlkktikdkklklkknelsdeki..s 137
                 +es +i+++ ++                                     ++ + +++ k+  ++ + l++++++l +ti++k+ +l++++    k+  +
  EFC37534.1 525 KESLRIQLTTNYiprkselqvlietlptdnsissshqtlmqlqT-----EKQVTEERIKDTTESVKRLDQEIDELGETIRNKQEQLETEKSEETKKlqT 618
                 55566666666666666666666666666666555444432220.....22222233333333334456666666666666666665444433332113 PP

      AAA_15 138 vekkkskkelpkekeeklekekeelkidkedlkklikkleeslkkee...............elknvlksaiiklllisakRnvsdedsekkssllgkl 221
                 +++k s+ e   +k++   ++kee  ++ ++l  l ++++++l+ ++               ++++v k+a+++++ +s++++    +++++ ++  k+
  EFC37534.1 619 LQEKASSLEKLLNKKKIWSQKKEECIKQIKELGTLPSDFRKYLETDQklllkklhntneklkKFGHVNKKALDQYEQFSNQKEE-FLEKKSELDSSAKA 716
                 333444444444444444444444444455555555555555555555222222222222224444444444444444444432.22222223333344 PP

      AAA_15 222 kekileealqekleeelteklkeiqeklkeidkklaeelkkilkkkidkikkfnykgkkneeieik............................ddeel 292
                 +++++   l+++ +e + + +k++q++++ei ++l      +l  k  + +        +ee e +                            d+ + 
  EFC37534.1 717 INELIQ-VLDKRKDEAIVRTFKQVQKNFQEIFQNLVPGGHASLSMKYRNGE--------DEEEEEEedeeakeveqyagvsikvsfmssgdseeDQSYH 806
                 444433.23333344444444444444444444433333333333333333........2222222444455556888999999999999999666666 PP

      AAA_15 293 plnknGsGvqrllllillileaekkdekeeknvilliEEPEahLHpqaqkvlikllkelandnktQviitT 363
                  + + + G+++l+ l l  +  +       +  ++l++E++a L p   +++++ +  l+ ++k Q i  T
  EFC37534.1 807 LMQQLSGGQKSLVALCLIFAIQRC-----DPAPFYLFDEIDAALDPAYRTSVANMIDTLSTKEKIQFITAT 872
                 777777777777766554444444.....488*******************************99*99877 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   7.2e-07    0.0016      10      47 ..      17      51 ..       8      56 .. 0.81

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 7.2e-07
      AAA_29 10 gtfdghtieidlkgatlltGpsGsGKSTllDAiqalLv 47
                +tf+ ++++ +     +++G++GsGKS ++ Ai+++L 
  EFC37534.1 17 QTFTSQEFSAS---QNIIVGRNGSGKSNFFSAISFVLS 51
                46666655555...489******************995 PP

>> AAA_27  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   0.1   4.5e-06      0.01       1      66 [.       1      70 [.       1     133 [. 0.73
   2 ?   -2.9   0.6       1.9   4.3e+03     158     200 ..     197     243 ..     186     250 .. 0.61
   3 ?   -0.6   0.2      0.37   8.2e+02     156     201 ..     398     443 ..     378     448 .. 0.54
   4 ?   -1.0   2.1      0.48   1.1e+03     157     199 ..     579     621 ..     555     635 .. 0.72
   5 ?   -2.7   0.2       1.7   3.7e+03     166     197 ..     686     717 ..     676     727 .. 0.58

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 4.5e-06
      AAA_27  1 MrlerLdLeryGkftdrsldfsaeeadlhliyGpNEAGKstalrAisdll...f.Gipertkdnflhdak 66
                M +++ +++ + ++ d++++ ++ +a+  +i+G N +GKs  ++Ais +l   f  +  +++++flh+ +
  EFC37534.1  1 MHIKSVTIQGFKSYRDQTFTSQEFSASQNIIVGRNGSGKSNFFSAISFVLsekFsKLRSEERQAFLHEGT 70
                99999***************99999*********************977744432467778888888754 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.9
      AAA_27 158 lrevleaLeaeadel..fkprkskk..rainealeeleeakkelrea 200
                 ++  l++Le+e++el  f++  + +   +++  ++el+ea+k+l+e 
  EFC37534.1 197 VQGRLDELEQEKEELkeFQKLDKDRrcVEYAIFEQELSEATKNLEEI 243
                 55566677766666533443333332345666677777777777665 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.37
      AAA_27 156 aslrevleaLeaeadelfkprkskkrainealeeleeakkelreaq 201
                 +++++ +++Le++ ++  ++ ++ + ++ +++++++  ++e+++ +
  EFC37534.1 398 KKIKASIATLEEQLNSCITDLHKVESEVHNSKNTIQYEQQEIHNLT 443
                 3444455555555555555555555555555555555555555555 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.48
      AAA_27 157 slrevleaLeaeadelfkprkskkrainealeeleeakkelre 199
                 + +e +++L++e del ++ ++k++++ ++++e ++  ++l+e
  EFC37534.1 579 DTTESVKRLDQEIDELGETIRNKQEQLETEKSEETKKLQTLQE 621
                 5567778888888888888887776666555555544444444 PP

  == domain 5  score: -2.7 bits;  conditional E-value: 1.7
      AAA_27 166 eaeadelfkprkskkrainealeeleeakkel 197
                 +++a + +++ +++k+++ e+++el++  k++
  EFC37534.1 686 NKKALDQYEQFSNQKEEFLEKKSELDSSAKAI 717
                 44444445555555555566666655555555 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   0.00015      0.33      18      58 ..       6      45 ..       3      51 .. 0.80
   2 ?   -1.4   0.1      0.55   1.2e+03      89     144 ..     716     772 ..     708     810 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00015
                  TEEEEEEETTS-EEEEEGGGS-.SEEEE--TTSSHHHHHHH CS
  FtsK_SpoIIIE 18 lpvalgkeisgnplvldlkkmashllvaGatgsGKStalnt 58
                  ++++ +k  +++ +++++ ++    +++G+ gsGKS++  +
    EFC37534.1  6 VTIQGFKSYRDQTFTSQEFSAS-QNIIVGRNGSGKSNFFSA 45
                  5666677778888888888777.8899**********9876 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.55
                   T-TTBSS.S-B-SHHHHHHHHHHHHHHHHHHHHHHHHTT-SSHHH.HHHHHHHHHHT CS
  FtsK_SpoIIIE  89 diphllsvavatdperalraleeLvkemeeryalfreagvrsiaa.ydgeiaedpld 144
                    i+ l++v +    e ++r+++++ k  +e ++ +   g +s+++ y+++  e++++
    EFC37534.1 716 AINELIQVLDKRKDEAIVRTFKQVQKNFQEIFQNLVPGGHASLSMkYRNGEDEEEEE 772
                   577777777777888899999999999999999999999999998744444444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (936 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3279  (0.182888); expected 358.6 (0.02)
Passed bias filter:                      578  (0.0322383); expected 358.6 (0.02)
Passed Vit filter:                       146  (0.00814323); expected 17.9 (0.001)
Passed Fwd filter:                        75  (0.00418317); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.83u 0.39s 00:00:02.22 Elapsed: 00:00:00.63
# Mc/sec: 4496.99
//
Query:       EFC37535.1  [L=847]
Description: hypothetical protein NAEGRDRAFT_59742 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (847 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1842  (0.102739); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.84u 0.40s 00:00:01.24 Elapsed: 00:00:00.55
# Mc/sec: 4603.89
//
Query:       EFC37536.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.4e-22   77.5   0.0    9.8e-22   77.0   0.0    1.3  1  Ribosomal_L5_C  ribosomal L5P family C-terminus
    6.8e-18   64.7   0.0    1.3e-17   63.9   0.0    1.5  1  Ribosomal_L5    Ribosomal protein L5


Domain annotation for each model (and alignments):
>> Ribosomal_L5_C  ribosomal L5P family C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.0   0.0   1.1e-25   9.8e-22       1      84 [.      71     150 ..      71     168 .. 0.91

  Alignments for each domain:
  == domain 1  score: 77.0 bits;  conditional E-value: 1.1e-25
  Ribosomal_L5_C   1 piGvkvtLrgekmyefldkllevvlprlrdFkGiskssfdgrGnvsfGikeqiifpeieydkdkgifGmditivttak...tdeear 84 
                     +i+++vt+rgek+ye+l+++l v+  +lr      +++f++ Gn++fGi+e+i++ +++yd+++gifGmdi++v+ ++   +++++r
      EFC37536.1  71 KIACSVTVRGEKAYELLERALRVKDFELR------QRNFSDAGNFGFGIQEHIDL-GLKYDPNIGIFGMDIFVVLGRPglrVSKKKR 150
                     69***************************......********************.*********************9877555444 PP

>> Ribosomal_L5  Ribosomal protein L5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.9   0.0   1.4e-21   1.3e-17       1      57 []      14      67 ..      14      67 .. 0.99

  Alignments for each domain:
  == domain 1  score: 63.9 bits;  conditional E-value: 1.4e-21
                  SCTTS-EEEEEEEEEE-SSSSSCHHHHHCCHHHHCCCHSS--EECC--TTCTTTCSC CS
  Ribosomal_L5  1 NvMqvPrleKivinmgvGeagedkkllekaakeLaeItGQkPvvtkakksianFkiR 57
                  N+M++++++K+++n+  Ge g++   l+kaa++L+ +tGQ Pv++ka+ +i++F+iR
    EFC37536.1 14 NPMRKVQIQKLCLNISPGEGGDR---LQKAARVLQDLTGQAPVFHKARLTIRSFGIR 67
                  9**********************...******************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       320  (0.0178482); expected 358.6 (0.02)
Passed bias filter:                      301  (0.0167884); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1039.39
//
Query:       EFC37537.1  [L=157]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.025   15.0   2.3        3.6    8.1   0.1    2.3  2  EF-hand_7  EF-hand domain pair
       0.52   10.4   3.3          1    9.4   0.2    2.9  2  EF-hand_6  EF-hand domain


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.1    0.0004       3.6      36      66 ..      24      52 ..       2      66 .. 0.69
   2 ?    6.7   0.3    0.0011        10      10      54 ..     103     142 ..     102     149 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0004
   EF-hand_7 36 gegsklsdeelellfkefDtdkdGvisfdEF 66
                +e+ +    ++ +l+kefD+ + G+++  + 
  EFC37537.1 24 SEEIE--TSQVVDLLKEFDKKRFGTLTIKDV 52
                33333..23488999**********998886 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0011
   EF-hand_7  10 elDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefD 54 
                  lD+  d  ++++++ +l+ +       +++ls e   +++ke+ 
  EFC37537.1 103 RLDNKSDRLIEENDMIKLIIQ-----MSDNSLSTEDASRMIKELQ 142
                 69************7779998.....7777777777777777765 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.2   0.00012         1       3      26 ..      33      56 ..      31      62 .. 0.88
   2 ?   -0.0   0.2      0.13   1.1e+03       8      27 ..     103     122 ..     102     141 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00012
   EF-hand_6  3 reaFklfDkdgdGkidaeElrkal 26
                 ++ k+fDk + G+++++++++ +
  EFC37537.1 33 VDLLKEFDKKRFGTLTIKDVQSQI 56
                57889***************9865 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.13
   EF-hand_6   8 lfDkdgdGkidaeElrkalr 27 
                  +D+  d  i  ++++k++ 
  EFC37537.1 103 RLDNKSDRLIEENDMIKLII 122
                 57777888899999888664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (157 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1147  (0.0639746); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 967.60
//
Query:       EFC37538.1  [L=273]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.7e-27   94.7   4.6    9.8e-27   94.1   4.6    1.2  1  dNK              Deoxynucleoside kinase
    6.5e-06   25.9   0.3       0.11   12.1   0.0    2.4  2  Thymidylate_kin  Thymidylate kinase
      0.001   19.5   0.5       0.11   12.9   0.5    2.3  1  AAA_17           AAA domain
     0.0032   18.0   1.3      0.027   15.0   1.3    2.3  1  AAA_18           AAA domain
     0.0064   16.7   0.0       0.11   12.6   0.0    2.7  1  AAA_33           AAA domain
  ------ inclusion threshold ------
      0.034   14.2   0.2       0.27   11.2   0.0    2.2  2  TsaE             Threonylcarbamoyl adenosine biosynthesis pro
      0.077   13.5   0.2       0.21   12.1   0.2    1.8  1  ABC_tran         ABC transporter
      0.089   12.6   0.8       0.27   11.0   0.0    2.1  2  ATP_bind_1       Conserved hypothetical ATP binding protein
       0.11   12.2   0.0       0.96    9.1   0.0    2.1  2  Cytidylate_kin   Cytidylate kinase
        3.8    8.3   5.3        1.6    9.5   1.9    2.5  3  Complex1_LYR_2   Complex1_LYR-like


Domain annotation for each model (and alignments):
>> dNK  Deoxynucleoside kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.1   4.6   5.4e-30   9.8e-27       1     172 [.      51     240 ..      51     271 .. 0.84

  Alignments for each domain:
  == domain 1  score: 94.1 bits;  conditional E-value: 5.4e-30
                 EEEEESTTSSHHHHHHHHHCCSTCEEEE-........HHHHCCSSSSHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHCHH.........SSS-EEEEES CS
         dNK   1 ivveGnIgaGKstlvklLskklgvkvfeE........pvdkwtnvqknlLekfYkdpsrwsfalqtyvllsrlkqqleal.........atkqvvvleR 82 
                 i+ +GnIg+GKstl k++++ +  ++ +          v+k+     +l +k+  +  ++++++q  ++  +++q l+ +         + k vv+++R
  EFC37538.1  51 IACDGNIGVGKSTLCKVMQQYIHKEFSSSillchieeDVEKN----IELFKKYLSNQREYGLEFQKWIIKDKIQQFLDKVsiwedenveQDKIVVIMDR 145
                 6789****************9975554444433211155555....589999999*********************999999****99888999***** PP

                 -HHHHHHTHHHHHHHTTSS-HHHHHHHHHHHHHHHHHCCH....-SEEEEEE--HHHHHHHHHHCTTCCCT.TS-HHHHHHHHHHHHHHHTSGGC CS
         dNK  83 siysdryiFakalaekgtlseeelkiykelldnlleelak....pdlliYLkasletclerikkRgreeek.kieldYlekLhekyeewlkklne 172
                 s   dr +F+ +l ek+ +s+e+l+ y++ ++++ +e +     pd++i L+as+++ +eri++R+r  e    +++Yl+ ++  + +++k+l  
  EFC37538.1 146 SLLADRFVFFRNLLEKKLMSQEQLQDYEQTFEKMSREYPVnlfyPDFHIILEASIDVAMERINRRNRVGESsVYNKNYLQMIEDFHLDMYKTLPV 240
                 ***********************************888777888***************************677899***********9998544 PP

>> Thymidylate_kin  Thymidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   6.2e-05      0.11       6      89 ..      58     147 ..      53     150 .. 0.77
   2 !   11.9   0.1   7.5e-05      0.13     107     157 ..     180     229 ..     158     259 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 6.2e-05
                      TSSHHHHHHHHHHHHHHTTE...EEEESSSTTSHHHHHHHHHHHTCS---HHHHHHHHHHHHHHTTHHHH..H..HHHHT.T-EEEEES-H CS
  Thymidylate_kin   6 GaGKttqaellkerlkeegik..vvltrepggteiGekirelllkeeeleeqteallfaadriehleeki..k..palkq.gktvivdRyl 89 
                      G+GK+t ++ + +++++e  +   +   e++  +  e+++++l+ +++   + +   + +d+i+++ +k+  +  ++++q + +vi+dR l
       EFC37538.1  58 GVGKSTLCKVMQQYIHKEFSSsiLLCHIEEDVEKNIELFKKYLS-NQREYGLEFQKWIIKDKIQQFLDKVsiWedENVEQdKIVVIMDRSL 147
                      99****************999955566799999999********.7777788889999999999999665222223344415568899987 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 7.5e-05
                      HHHHGGGTTSE-SEEEEEESSHHHHHTSCCTTSSTTTSHHHHHHHHHHHHH CS
  Thymidylate_kin 107 vlslnedvllkPdltflldvdpevalkRlakrdeldeeeeeqldflrkvre 157
                       ++   +++  Pd+ ++l+ + +va++R+++r+   e    ++++l+ ++ 
       EFC37538.1 180 SREYPVNLF-YPDFHIILEASIDVAMERINRRNRVGESSVYNKNYLQMIED 229
                      444444555.9**********************955665556555655554 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.5   6.2e-05      0.11       4     109 ..      57     156 ..      55     222 .. 0.56

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 6.2e-05
                 TTSSHHHHHHHHHHHHTEEEEEHHHHHHHHHHTTTSHSSHHHHCTSHHHHHHHHHHHHHHHHHHHHHSSEEEEEE-SEEEETTEEEESSHHHHHHHH.. CS
      AAA_17   4 PGsGKgtqceklvekygfthlsaGdllreeakrgglakardemrklpleekkelqkeaaekiaeeakkkgvlvdghprikeqagfldglpkevleelkp 102
                  G+GK+t+c k++++y  + +s + ll    +++  +k+ + + k +l+ ++e+  e ++ i +++   +  +d+   +++++ + d++ + + ++l  
  EFC37538.1  57 IGVGKSTLC-KVMQQYIHKEFSSSILLCHI-EED-VEKNIELF-KKYLSNQREYGLEFQKWIIKDKI--QQFLDKVSIWEDENVEQDKIVVIMDRSLLA 149
                 59*******.9*****99999977777643.322.22233333.33444444444444444444322..234444444444444444444444444444 PP

                 SEEEEEE CS
      AAA_17 103 daiille 109
                 d ++++ 
  EFC37538.1 150 DRFVFFR 156
                 4444443 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   1.3   1.5e-05     0.027       5     115 ..      55     212 ..      51     227 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.5e-05
      AAA_18   5 GtpGvGKttlakeL....skrlgf...........gvnlrdvakenglllevdpealdeskrldedkldklldaleenssaleegknl..vidghlael 86 
                 G +GvGK+tl+k       k+  f            v+ +  +++++l+  ++   l+ +k + +dk ++ ld++  + + + e++ +  ++d  l   
  EFC37538.1  55 GNIGVGKSTLCKVMqqyiHKE--FsssillchieeDVEKNIELFKKYLSNQREYG-LEFQKWIIKDKIQQFLDKVSIWEDENVEQDKIvvIMDRSLLAD 150
                 779*********994433333..25567777887744444444444555555555.8888888888888888888888884444444422444333322 PP

      AAA_18  87 eseaakdikk...................................vvLtaspeelleRlekRgy 115
                 ++  ++  +                                    ++L+as ++ +eR+++R++
  EFC37538.1 151 RFVFFR--NLlekklmsqeqlqdyeqtfekmsreypvnlfypdfhIILEASIDVAMERINRRNR 212
                 222222..22335677888888888888888888999999999999999999999999999985 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   6.4e-05      0.11       2     138 ..      51     228 ..      50     232 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6.4e-05
      AAA_33   2 vllvGlpGsGKstlaerl....lkklg....avllssdtlrr.rlfg....tdqqsktdytr..vldrlyqilnela....rkalsagrnvildat... 78 
                 + + G  G+GKstl + +    +k+       +++++d++++  lf+    ++++   + ++  ++d++ q+l ++     + + + ++ vi d     
  EFC37538.1  51 IACDGNIGVGKSTLCKVMqqyiHKEFSssilLCHIEEDVEKNiELFKkylsNQREYGLEFQKwiIKDKIQQFLDKVSiwedENVEQDKIVVIMDRSlla 149
                 5667889******9987655544444499999*******888888887665666665555553344667777755543332345567777888888888 PP

      AAA_33  79 .............nlsrrerarflklarrlgvp........vrivvvetdeetlkeRlakRaangddrsevpeealdrqka 138
                              + s+++ +++ + +++++ +        +  +++e++ +++ eR+ +R++ g+++  v  ++  ++++
  EFC37538.1 150 drfvffrnllekkLMSQEQLQDYEQTFEKMSREypvnlfypDFHIILEASIDVAMERINRRNRVGESS--VYNKNYLQMIE 228
                 887777766666655566666666666666544666677779999******************98865..66666666665 PP

>> TsaE  Threonylcarbamoyl adenosine biosynthesis protein TsaE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00015      0.27      21      43 ..      45      72 ..      21      81 .. 0.67
   2 ?    0.1   0.1      0.42   7.6e+02      66      77 ..     229     240 ..     217     264 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00015
                E.....EEEEESTTSSHHHHHHHHHHHT CS
        TsaE 21 v.....ilLeGdLGaGKTtlvrglakal 43
                      i+ +G++G+GK+tl++ + + +
  EFC37538.1 45 QwnvfvIACDGNIGVGKSTLCKVMQQYI 72
                13334499**************998776 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.42
                 EEEEE-TT-SST CS
        TsaE  66 lyHfDlYRlede 77 
                  +H+D+Y+    
  EFC37538.1 229 DFHLDMYKTLPV 240
                 48*****96444 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.2   0.00012      0.21      18      99 ..      55     133 ..      45     183 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00012
                 ESTTSSHHHHHHHHTTSS--.SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH..HHHTCHHHHHHHSTTGGTTC CS
                 xxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  18 GenGaGKStLlkllagllkp.teGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren..esdeeiekalsklglkelkd 99 
                 G+ G GKStL+k++ +  ++  + +ill       + +e ++k+i+ +++  + ++e+ ++ +    +++i+++l+k+++ e+++
  EFC37538.1  55 GNIGVGKSTLCKVMQQYIHKeFSSSILLC------HIEEDVEKNIELFKKYLSNQREYGLEFQkwIIKDKIQQFLDKVSIWEDEN 133
                 888***********998887334455322......35566777777776664444444222223466777777777777776433 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00015      0.27       3      23 ..      55      75 ..      53      81 .. 0.88
   2 ?   -0.7   0.1      0.54   9.7e+02     127     149 ..     140     161 ..     132     258 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00015
  ATP_bind_1  3 GpaGsGKttfvgalseilelr 23
                G  G+GK+t+++ ++++++++
  EFC37538.1 55 GNIGVGKSTLCKVMQQYIHKE 75
                889**************9976 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.54
  ATP_bind_1 127 vyLvDsqrltdptkfisgllsal 149
                 v+++D   l+d   f+ +ll   
  EFC37538.1 140 VVIMDRSLLADRFVFFRNLL-EK 161
                 66667777777666666633.22 PP

>> Cytidylate_kin  Cytidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.0   0.00054      0.96       1      26 [.      51      76 ..      51      85 .. 0.85
   2 ?    0.3   0.0      0.26   4.7e+02     131     165 ..     191     228 ..     186     243 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00054
                    EEEE-STTSSHHHHHHHHHHHHT-EE CS
  Cytidylate_kin  1 iaiDGPagsGKssvaralaeklglky 26
                    ia DG  g GKs++++ + + +  ++
      EFC37538.1 51 IACDGNIGVGKSTLCKVMQQYIHKEF 76
                    89***************998777665 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.26
                     SEEEEEE--HH...HHHHHHHHHHHHTT----HHHHHH CS
  Cytidylate_kin 131 elKifldAsve...eRakRRlkqlkakgtsvsleella 165
                     ++ i l+As++   eR++RR++  +++ +++++ ++++
      EFC37538.1 191 DFHIILEASIDvamERINRRNRVGESSVYNKNYLQMIE 228
                     57788999987222577777776666655555555554 PP

>> Complex1_LYR_2  Complex1_LYR-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   1.9   0.00088       1.6      22      58 ..      67     111 ..       2     181 .. 0.82
   2 ?   -3.4   0.0       9.7   1.7e+04      52      64 ..     222     232 ..     219     255 .. 0.69
   3 ?   -3.3   0.0       9.3   1.7e+04      35      49 ..     251     266 ..     241     267 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00088
  Complex1_LYR_2  22 lgdayvraefrrhk.......hlk.npeeialflknqreYaelle 58 
                       ++y+++ef ++        +++ n e ++++l+nqreY    +
      EFC37538.1  67 VMQQYIHKEFSSSIllchieeDVEkNIELFKKYLSNQREYGLEFQ 111
                     5689999999995499*66666666666666*********76555 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 9.7
  Complex1_LYR_2  52 eYaellerynpgl 64 
                     +Y++++e +   l
      EFC37538.1 222 NYLQMIEDF--HL 232
                     666666666..33 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 9.3
  Complex1_LYR_2  35 khlknpe.eialflkn 49 
                     + +++   +i +fl++
      EFC37538.1 251 NSINQSItNIEQFLTE 266
                     5677444489999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (273 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1011  (0.0563891); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 1796.36
//
Query:       EFC37539.1  [L=940]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.8e-17   61.3   8.3    1.2e-16   60.6   8.3    1.4  1  RINGv        RING-variant domain
     0.0082   16.5   8.1      0.014   15.7   8.1    1.4  1  zf-RING_2    Ring finger domain
  ------ inclusion threshold ------
      0.019   15.0   3.3      0.039   14.0   3.3    1.5  1  zf-ANAPC11   Anaphase-promoting complex subunit 11 RING-H2 fi
       0.27   11.3   0.9       0.83    9.7   0.9    1.8  1  DUF4501      Domain of unknown function (DUF4501)
       0.32   11.6  11.4       0.72   10.5   0.5    4.2  4  Ctr          Ctr copper transporter family
       0.57   10.1   6.0       0.17   11.9   2.4    2.0  2  Baculo_IE-1  Baculovirus immediate-early protein (IE-0)
        1.9    8.3   9.1        3.5    7.5   9.1    1.5  1  zf-RING_4    RING/Ubox like zinc-binding domain
        2.3    8.4  16.8       0.28   11.4   6.2    2.2  2  PNISR        Arginine/serine-rich protein PNISR
        6.7    5.4  14.4       0.02   13.7   4.8    1.6  2  Tim54        Inner membrane protein import complex subunit Ti


Domain annotation for each model (and alignments):
>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.6   8.3   5.8e-20   1.2e-16       1      48 []      60     107 ..      60     107 .. 0.99

  Alignments for each domain:
  == domain 1  score: 60.6 bits;  conditional E-value: 5.8e-20
                 ETTTTEE-SSSS--B-SS--STCCCSB-HHHHHHHHHHTCT-SB-TTT CS
       RINGv   1 CriCleeeeeseplispCkCrGslklvHesClekWldekeantqCeiC 48 
                 CriC++ +++++pl++pCkC+Gs+k++HesCl++W++++++ + CeiC
  EFC37539.1  60 CRICKQPAADDDPLFHPCKCSGSIKYIHESCLNEWMKHSNKGKYCEIC 107
                 **************************************999999**** PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   8.1     7e-06     0.014       3      44 .]      60     108 ..      58     108 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 7e-06
   zf-RING_2   3 CpICleelssadsvl.llpCgH..v.fhreClerwlrssst...CPlCr 44 
                 C IC ++  ++d +   ++C+     +h++Cl++w+++s++   C +C+
  EFC37539.1  60 CRICKQPAADDDPLFhPCKCSGsiKyIHESCLNEWMKHSNKgkyCEICK 108
                 ****99998888877344787444347*********************7 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   3.3     2e-05     0.039      33      84 ..      58     114 ..      43     115 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2e-05
                 S--TTCSTTT.TTS-EEE.BTTS...-EEEHHHHHHHHHHHSTSSB-TTTSSB--BE CS
  zf-ANAPC11  33 GtcpsckfpG.ddcplvl.Gkck...hnfhlhcilkwletetskglcpmcrqtfklk 84 
                   c  ck p  dd pl    kc+   + +h+ c+ +w+++++  + c +c+ +fk++
  EFC37539.1  58 ALCRICKQPAaDDDPLFHpCKCSgsiKYIHESCLNEWMKHSNKGKYCEICKHQFKFE 114
                 57999***9647778776246763224579************************986 PP

>> DUF4501  Domain of unknown function (DUF4501)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.9   0.00042      0.83      87     142 ..     520     575 ..     507     581 .. 0.90

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00042
     DUF4501  87 aaslllgtlfislfLilsvasffylkrssklPkvfYrrnkasvlqpseaaamippP 142
                 a  ++l  +++ + L+ s   ff  +  s lP+ f +++ ++ +  +++a+mi++ 
  EFC37539.1 520 ATNFILVPFLVGMLLVFSTIEFFKRNEKSVLPQDFTTTSNSTSFSIADQASMIYNS 575
                 77889999**************99999999***********************864 PP

>> Ctr  Ctr copper transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.5   2.9e+03      83     121 ..      55     142 ..      10     172 .. 0.45
   2 ?   10.5   0.5   0.00036      0.72      83     136 ..     264     389 ..     201     392 .. 0.63
   3 ?    4.6   0.9     0.024        47       5      53 ..     605     652 ..     601     673 .. 0.78
   4 ?   -2.9   0.2       4.7   9.4e+03      25      48 ..     682     707 ..     675     720 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.5
         Ctr  83 a.....................................................kstsslskseakksvrttpeqqlirallyvvqvllaYi 121
                 +                                                     ++ + ++  ++  ++++      ++ +l ++ v+++Y+
  EFC37539.1  55 QdealcrickqpaadddplfhpckcsgsikyihesclnewmkhsnkgkyceickHQFKFEKVYTTDAPIKL----SPLQFILGLLSVVFSYL 142
                 24555555555555555555555555555555555555555544444333332211122222222222222....23344444445555554 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00036
         Ctr  83 a...............................................................kstsslskseakksvrttpe.........qqlira 109
                 +                                                               ++ +++ +++++ + +++ e          +li++
  EFC37539.1 264 NevltlrdllnqeqemqeedenngnennedqeeeeeeeeeenienenndnqpniiqppqpivnnQPPNNPPQQQQQPREELDLEemigikgkiSHLIET 362
                 1455555555555555555555555555555555555555556666778889999999988877555555555555555555558888888888***** PP

         Ctr 110 llyvvqvllaYilMLlvMtyNvglfla 136
                 +  v+ v  + il Ll+   ++g fl+
  EFC37539.1 363 VALVLFVNSQHILLLLFLPLQIGRFLC 389
                 *****999********99999988888 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.024
         Ctr   5 wstddtilfrsWritskgqlagsciglfllaifyeflralrerlerewd 53 
                     + +l+r   i s+ +++ +++g+++++i   f+++lr+ l++++ 
  EFC37539.1 605 SVSVEWVLSRMVYIMSV-SFIYFVFGIVVVVIASSFIQMLRSFLSKRVL 652
                 44555588888888887.999*********************9988665 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 4.7
         Ctr  25 agscigl..fllaifyeflralrerl 48 
                 ++s+++l  ++la++   l+  r+ l
  EFC37539.1 682 FFSFVFLsiLVLALVRTPLKLARFIL 707
                 55555551166666666666666665 PP

>> Baculo_IE-1  Baculovirus immediate-early protein (IE-0)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   2.4   8.3e-05      0.17      82     136 ..      59     116 ..      27     121 .. 0.83
   2 ?   -3.0   0.1       3.2   6.3e+03      37      75 ..     389     430 ..     377     443 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 8.3e-05
  Baculo_IE-1  82 qcnicedtsaeer.flkPneccGy..kicnlcyanlwkfstvyPvcPvcktsfksssk 136
                   c ic++ +a++   + P +c G    i   c  +  k+s+    c +ck  fk +++
   EFC37539.1  59 LCRICKQPAADDDpLFHPCKCSGSikYIHESCLNEWMKHSNKGKYCEICKHQFKFEKV 116
                  4****998776552779*****953258889****9******************8876 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 3.2
  Baculo_IE-1  37 ckklvkkl..kaaldelleeseksleviklinervqvln.vf 75 
                  c+++v++l  ++ + ++l+e +   ++ ++i++ +q +n vf
   EFC37539.1 389 CTTIVQELdiSSVIYQVLAEHNLLKNTTQIISNVTQTMNeVF 430
                  566665541133445555555555555566666666665233 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   9.1    0.0018       3.5       1      48 []      60     112 ..      60     112 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0018
   zf-RING_4   1 cplCdeeldetdkdlkpCeCgyqi...ClfCyhrile..eeegrCPaCreeYk 48 
                 c++C +++ ++d  ++pC+C   i      C+++ ++  ++++ C  C++++k
  EFC37539.1  60 CRICKQPAADDDPLFHPCKCSGSIkyiHESCLNEWMKhsNKGKYCEICKHQFK 112
                 99******************96642224567777777556899*******986 PP

>> PNISR  Arginine/serine-rich protein PNISR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   2.9     0.078   1.5e+02      62     111 ..       8      57 ..       2      78 .. 0.64
   2 ?   11.4   6.2   0.00014      0.28      32     141 ..     246     343 ..     231     441 .. 0.53

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.078
       PNISR  62 lakskfdsedeksdeeeeeg.aegedsesqekasskksevdeqespeeeea 111
                  +++ fd+++e++++ + e+ + +e+ ++++ ++++++e+ ++ ++  +++
  EFC37539.1   8 EEEIDFDQQQEEQQHYHGEDiHSDENILNESTSNDNQEEIVNSDEQ-GQDE 57 
                 5678889999888888866665555555666666777766666666.3333 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00014
       PNISR  32 errekeraerrkeekkesskeeeeaknprnlakskfdsed..eksdeeeeegaegedsesqekasskksevdeqespeeeeaarkeieesspaeeeeee 128
                 +++          +  + ++ ++ ++n +++  ++   ++  e+++e+e++g+e+++++++e+++++++++++++++    ++ + i+  +p  ++++ 
  EFC37539.1 246 NQP----------QPVNAQVANNANNNNNEVLTLRDLLNQeqEMQEEDENNGNENNEDQEEEEEEEEEENIENENND----NQPNIIQPPQPIVNNQPP 330
                 222..........1222222222222222222222222220022222222233333333333333333334443333....222222333332222222 PP

       PNISR 129 epeakteeekqae 141
                 +++ +++++ ++e
  EFC37539.1 331 NNPPQQQQQPREE 343
                 2222222222222 PP

>> Tim54  Inner membrane protein import complex subunit Tim54
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.5   2.1       7.1   1.4e+04     359     365 ..      26      32 ..       5      58 .. 0.33
   2 ?   13.7   4.8     1e-05      0.02     204     323 ..     275     414 ..     232     465 .. 0.56

  Alignments for each domain:
  == domain 1  score: -5.5 bits;  conditional E-value: 7.1
       Tim54 359 qelvlDe 365
                 ++++ De
  EFC37539.1  26 EDIHSDE 32 
                 1111111 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1e-05
       Tim54 204 eeeeeeeekeeeeeeeeeeeeekeeekeeekeeeeeeeekekkkkvpkpyispedYasaelppe.......................iPell...qpvl 276
                 +e+e +ee+e++ +e++e++ee+eee+eee+ e+e+++++++  + p+p i +++      p++                       i +l+     vl
  EFC37539.1 275 QEQEMQEEDENNGNENNEDQEEEEEEEEEENIENENNDNQPNIIQPPQP-IVNNQ-----PPNNppqqqqqpreeldleemigikgkISHLIetvALVL 367
                 2223333333333333233333333333333333333444432222222.22222.....222222234556679999999999999555551014455 PP

       Tim54 277 viplphllGflntpiriyrfltrRkladevgrevaavvlakirpyee 323
                  ++  h+l +l +p +i rfl    + +   ++v   vla++   ++
  EFC37539.1 368 FVNSQHILLLLFLPLQIGRFLCTTIVQELDISSVIYQVLAEHNLLKN 414
                 66778899999999999999988877776555555555555554444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (940 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2571  (0.143399); expected 358.6 (0.02)
Passed bias filter:                      757  (0.0422221); expected 358.6 (0.02)
Passed Vit filter:                       172  (0.0095934); expected 17.9 (0.001)
Passed Fwd filter:                        46  (0.00256568); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 1.11u 0.32s 00:00:01.43 Elapsed: 00:00:00.51
# Mc/sec: 5516.17
//
Query:       EFC37540.1  [L=173]
Description: hypothetical protein NAEGRDRAFT_81908 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.2e-06   27.5   8.4    2.2e-06   27.5   8.4    1.9  2  TB2_DP1_HVA22  TB2/DP1, HVA22 family
  ------ inclusion threshold ------
      0.028   14.2   0.1      0.055   13.3   0.1    1.4  1  DASH_Duo1      DASH complex subunit Duo1
      0.091   12.6   0.1       0.12   12.2   0.1    1.1  1  Yuri_gagarin   Yuri gagarin


Domain annotation for each model (and alignments):
>> TB2_DP1_HVA22  TB2/DP1, HVA22 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   8.4   3.7e-10   2.2e-06      22      63 ..       1      43 [.       1      56 [. 0.84
   2 ?   -0.7   0.4      0.22   1.3e+03      44      73 ..      62      89 ..      42      93 .. 0.55

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 3.7e-10
  TB2_DP1_HVA22 22 tYWvvfafltvvesladvlls.wiPfYylfKllfllwlvlpqt 63
                   +YW+v+a+++ +e+++ ++l+ ++PfY ++K++ ll lv+ ++
     EFC37540.1  1 MYWCVMAAFLSLENIFYFVLYsLVPFYPEIKVVSLLILVVSNY 43
                   7***************6666549***************98654 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.22
  TB2_DP1_HVA22 44 iPfYylfKllfllwlvlpqtqgatyvYekf 73
                   iP+Y     +f+   v   t g ++++ k+
     EFC37540.1 62 IPYYVN--HVFVNHAVTYLTYGIRFIFSKL 89
                   454433..3333334443477777777776 PP

>> DASH_Duo1  DASH complex subunit Duo1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   9.2e-06     0.055       5      39 ..     100     134 ..      96     137 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 9.2e-06
   DASH_Duo1   5 EleqLrkinevienviesLkkaksniervketves 39 
                  leqL++++ +i+++  +Lkk++++++r++++ +s
  EFC37540.1 100 NLEQLDSMIGAIDDISYELKKIRKETQRLHQRGSS 134
                 79***************************998665 PP

>> Yuri_gagarin  Yuri gagarin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1     2e-05      0.12      74     131 ..      98     155 ..      82     164 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2e-05
  Yuri_gagarin  74 rdeqikqlqsmitsysdls.ennrlkeeiydlkqknceqarkvrelaeelkgeeeqrve 131
                   rd  ++ql+smi++ +d+s e +++++e+  l q+ + ++   + l++   ++  +rv 
    EFC37540.1  98 RD-NLEQLDSMIGAIDDISyELKKIRKETQRLHQRGSSNSSSGKVLTSTTSSDALRRVS 155
                   44.579************857799*************9999888888877777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (173 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       867  (0.0483574); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1016.05
//
Query:       EFC37541.1  [L=400]
Description: arfGTPase-activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      1e-38  132.0   0.5      1e-38  132.0   0.5    2.7  3  ArfGap        Putative GTPase activating protein for Arf
  ------ inclusion threshold ------
       0.15   12.3  17.5       0.17   12.2   6.8    2.3  2  GAGA_bind     GAGA binding protein-like family
        1.9    8.5   6.0       0.83    9.6   1.9    2.4  3  TEX19         Testis-expressed protein 19


Domain annotation for each model (and alignments):
>> ArfGap  Putative GTPase activating protein for Arf
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  132.0   0.5   1.7e-42     1e-38       2     115 ..      50     164 ..      49     166 .. 0.95
   2 ?   -0.7   1.3      0.25   1.5e+03      84     107 ..     196     217 ..     173     229 .. 0.49
   3 ?   -2.6   0.4      0.91   5.4e+03      89      89 ..     358     358 ..     327     389 .. 0.50

  Alignments for each domain:
  == domain 1  score: 132.0 bits;  conditional E-value: 1.7e-42
                 HHHHHHCCSCCCCB-TTT-SBS--EEETTTTEEE-HHHHHHHCCS.TTT--EEETTTS---HHHHHHHHHTCHHHHHHHHTTTC-TTTSG.-TTCGHHH CS
      ArfGap   2 kalkellkepenkvCaDCgakeptWaslnlgvflCieCsgvHrslgvhiskvrsltldkwedeelellkalgNkkaneileaklpkeekr.skssskek 99 
                 k+l+ l+k+p+n  CaDC++++p W+s ++g+f+C++C+g+Hrslg+his+vrs+++dkw+++++++++ +gN++a++++e +lp+++k+    +s++ 
  EFC37541.1  50 KILSVLIKKPGNGECADCTEARPVWCSATFGTFICLRCAGIHRSLGSHISFVRSAEMDKWDEKHVKIMQLMGNERAKQYFECNLPEDKKKpARIDSTQV 148
                 5688899*****************************************************************************99999878889999* PP

                 HHHHHHHHHTCHTTCC CS
      ArfGap 100 reefirakYeekkfae 115
                 +e++i++kY++ k++ 
  EFC37541.1 149 VEQYIKEKYVNLKYVP 164
                 ***********99975 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.25
                 TC-TTTSG-TTCGHHHHHHHHHHH CS
      ArfGap  84 klpkeekrskssskekreefirak 107
                 +++k+ek+  ++s+++ ++ +++k
  EFC37541.1 196 QKKKKEKS--EKSEKSEKTTVKKK 217
                 22222222..22223333333333 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.91
                 T CS
      ArfGap  89 e 89 
                 +
  EFC37541.1 358 Q 358
                 1 PP

>> GAGA_bind  GAGA binding protein-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   6.8   2.8e-05      0.17      98     191 ..     140     243 ..      84     288 .. 0.50
   2 ?    5.6   2.9    0.0027        16     133     183 ..     332     384 ..     303     397 .. 0.48

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.8e-05
   GAGA_bind  98 laalqmlr...........plesqlqeaeapelekeevasselveesavvekeeaakkrqqgkrpkepkakkakkaarkpkeegedlalkkakrsksek 185
                  a ++ ++           +l+  +++++ ++++ +e  +  + ++++   ++ +++k++++k++k++k++k++ +++k+k+   d   ++++++ ++k
  EFC37541.1 140 PARIDSTQvveqyikekyvNLKYVPKKEDGKKMTFKEFLELAKQHDEPNEDDTLPQQKKKKEKSEKSEKSEKTTVKKKKVKKVVADES-SSSPTTTTSK 237
                 2333332233333323222233344444444445555543333333333333333333333355555555444444444444443332.2223333333 PP

   GAGA_bind 186 ksvdlv 191
                 k+++  
  EFC37541.1 238 KKTETT 243
                 333332 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0027
   GAGA_bind 133 savvekeeaakkrqqgkrpkepkakkakkaarkpkeegedl...alkkakrsks 183
                 s+++++++a kk++ +k+ k  k+kk++ + ++ +++ +      ++k++++k+
  EFC37541.1 332 SSTITETTAPKKKTVKKSVKPIKTKKQESSDNEDEDSAD-EydaIFQKTTTQKA 384
                 222333355666666555555555555553333333332.23444444433332 PP

>> TEX19  Testis-expressed protein 19
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.32   1.9e+03      48      66 ..     103     122 ..      83     158 .. 0.65
   2 ?    9.6   1.9   0.00014      0.83      44     130 ..     173     259 ..     169     266 .. 0.87
   3 ?   -2.4   0.1      0.71   4.2e+03      51      58 ..     360     367 ..     318     395 .. 0.60

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.32
       TEX19  48 lleledWededwd.aelmel 66 
                   e+++W++++    +lm +
  EFC37541.1 103 SAEMDKWDEKHVKiMQLMGN 122
                 55788887765431334433 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00014
       TEX19  44 dlkelleledWededwdaelmelseagseqeaspgvelswgqgslqvaqgvsealgsgalasapeeseevgldshfvPtelePqeav 130
                 ++ke+lel +  de  + +++ + ++++e+ +++++ ++ ++ + +v++ v+++ +s    +++++  e+ +++    t l+P  + 
  EFC37541.1 173 TFKEFLELAKQHDEPNEDDTLPQQKKKKEKSEKSEKSEKTTVKKKKVKKVVADESSSSPTTTTSKKKTETTVEDLIGITTLSPSSTQ 259
                 689***********9999999999999999999999999999999999999999998888888888888889999888999997765 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 0.71
       TEX19  51 ledWeded 58 
                 + d eded
  EFC37541.1 360 SSDNEDED 367
                 22222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (400 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3224  (0.17982); expected 358.6 (0.02)
Passed bias filter:                      624  (0.0348039); expected 358.6 (0.02)
Passed Vit filter:                       108  (0.00602376); expected 17.9 (0.001)
Passed Fwd filter:                        41  (0.0022868); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.86u 0.35s 00:00:01.21 Elapsed: 00:00:00.50
# Mc/sec: 2415.18
//
Query:       EFC37542.1  [L=466]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-10   39.8  11.5    0.00018   22.2   0.2    5.8  7  WD40         WD domain, G-beta repeat
     0.0012   19.1   0.0       0.53   10.6   0.0    3.9  5  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
  ------ inclusion threshold ------
      0.027   14.4   0.0       0.34   10.9   0.0    2.3  2  FBA_3        F-box associated domain
      0.041   12.5   0.0        1.8    7.1   0.0    2.2  2  ELYS-bb      beta-propeller of ELYS nucleoporin
      0.054   12.6   0.5      0.097   11.8   0.5    1.3  1  DUF5520      Family of unknown function (DUF5520)
        6.7    4.7  10.6        9.1    4.2  10.6    1.1  1  DNA_pol_phi  DNA polymerase phi


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       1.4   4.2e+03      12      24 ..      19      35 ..      10      43 .. 0.74
   2 ?    1.4   0.0      0.23   6.7e+02      19      38 .]     190     209 ..     175     209 .. 0.75
   3 !   22.2   0.2   6.1e-08   0.00018       9      38 .]     237     267 ..     229     267 .. 0.87
   4 !    6.7   0.0     0.005        15       6      38 .]     276     312 ..     271     312 .. 0.75
   5 ?   -0.7   0.0       1.1   3.3e+03      13      28 ..     335     351 ..     326     361 .. 0.65
   6 !   11.5   0.2   0.00015      0.44       4      38 .]     369     406 ..     366     406 .. 0.71
   7 ?   -3.5   0.0         6   1.8e+04      11      21 ..     425     435 ..     419     436 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.4
                S....EEEEEEETTSSE CS
        WD40 12 s....vtslafspdgaw 24
                s    ++s+++ p ga+
  EFC37542.1 19 StsnvISSISWVPKGAF 35
                2446579**99999988 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.23
                 ETTSSEEEEEETTSEEEEEE CS
        WD40  19 spdgawlasGsdDgtvriWd 38 
                 s+ ++ +a G+  + + iWd
  EFC37542.1 190 SQPSNCIAIGTFEPQIEIWD 209
                 556667788988*******9 PP

  == domain 3  score: 22.2 bits;  conditional E-value: 6.1e-08
                 SS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   9 GH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 GH + + s++f ++ + lasGsdD+++ iWd
  EFC37542.1 237 GHkGAILSMSFRSSDSKLASGSDDKSIVIWD 267
                 9*555*****9999999*************9 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.005
                 EEESS..SSEEEEEEETTSSE.EEEE..ETTSEEEEEE CS
        WD40   6 tltGH..ssvtslafspdgaw.lasG..sdDgtvriWd 38 
                   +G   s++ s++f++  +  l+++  s D+ ++++d
  EFC37542.1 276 QVKGAgaSPIQSVQFHHTEQNiLLACpiS-DHVCKVFD 312
                 5566664779***97777777356999**.******98 PP

  == domain 5  score: -0.7 bits;  conditional E-value: 1.1
                 EEEEEEETTSSE.EEEE CS
        WD40  13 vtslafspdgaw.lasG 28 
                 + s  ++p++++ ++++
  EFC37542.1 335 IESAIWNPNNPYeFVCA 351
                 66666899998864433 PP

  == domain 6  score: 11.5 bits;  conditional E-value: 0.00015
                 EEEEESSSS..EEEEEEETTSSEEEE..EETTSEEEEEE CS
        WD40   4 lrtltGHss..vtslafspdgawlas..GsdDgtvriWd 38 
                 ++ + +Hs+   +s++fs  ++ l++  Gs D  vr+W+
  EFC37542.1 369 VYNINAHSGasCSSISFSNLKSNLMAsvGS-DSCVRLWN 406
                 566678933458899888888888641257.*******8 PP

  == domain 7  score: -3.5 bits;  conditional E-value: 6
                 SSEEEEEEETT CS
        WD40  11 ssvtslafspd 21 
                 s+++s+af p+
  EFC37542.1 425 SDIYSCAFAPS 435
                 46999999886 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.65   1.9e+03      30      52 ..      11      35 ..       5      39 .. 0.71
   2 !   10.6   0.0   0.00018      0.53      35      89 ..     236     290 ..     196     293 .. 0.88
   3 ?    0.9   0.0       0.2   5.9e+02      37      70 ..     281     316 ..     274     327 .. 0.77
   4 ?    1.6   0.0      0.12   3.5e+02      41      89 ..     335     385 ..     329     388 .. 0.78
   5 ?    1.6   0.0      0.11   3.4e+02      25      70 ..     365     410 ..     351     430 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.65
  ANAPC4_WD40 30 wtl..eedkedsevrsLaWkpdgkl 52
                 ++   +++++++ ++s++W p+g +
   EFC37542.1 11 YQSgnDASSTSNVISSISWVPKGAF 35
                 5554344566778999***999975 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00018
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                   ++++ + s++++ +++ La + +d ++ + d +++k   +++ +  + ++++++
   EFC37542.1 236 MGHKGAILSMSFRSSDSKLASGSDDKSIVIWDLSNQKPFYQVKGAGASPIQSVQF 290
                  567899********************************99999877777777776 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.2
  ANAPC4_WD40  37 edsevrsLaWkpdgk..lLavaysdgevrlldaesg 70 
                    s ++s+++++ ++  lLa  +sd  ++++da+++
   EFC37542.1 281 GASPIQSVQFHHTEQniLLACPISDHVCKVFDAKQQ 316
                  567788888888776336777789999999999876 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.12
  ANAPC4_WD40  41 vrsLaWkpdgkl.Lavaysdgevrlldaesgkv.vhslsvksekavtclgW 89 
                  ++s  W+p++   ++ a ++g +  +d+ ++k+ v +++++s  + +++++
   EFC37542.1 335 IESAIWNPNNPYeFVCAQDNGFITCFDIRNEKTpVYNINAHSGASCSSISF 385
                  5666788888653677888899******99886589999999887777766 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.11
  ANAPC4_WD40  25 ngqrvwtleedkedsevrsLaWkp.dgklLavaysdgevrlldaesg 70 
                  +   v+++ +++++ + +s+++++ + +l+a + sd+ vrl + ++ 
   EFC37542.1 365 EKTPVYNI-NAHSGASCSSISFSNlKSNLMASVGSDSCVRLWNTKTS 410
                  55567777.77888888899997636788999999999999987765 PP

>> FBA_3  F-box associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.17   5.2e+02      62      88 ..     146     172 ..     139     196 .. 0.77
   2 ?   10.9   0.0   0.00011      0.34      17      73 ..     352     405 ..     346     448 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.17
       FBA_3  62 kksekv.neielWVleDaekqeWskktf 88 
                 ++++   +++++W+ e++e + ++ + +
  EFC37542.1 146 NEED-GlTTLQVWIYEQEEDNLFMHHDL 172
                 3333.3489*******999987777765 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00011
       FBA_3  17 neklvivsFDvrsEkfkfiklpeeklesllsktLinYkGklavvekksekvneielW 73 
                 +++ +i +FD+r Ek  + +++++  +s+ s ++ n k+ l   +  s+  + ++lW
  EFC37542.1 352 QDNGFITCFDIRNEKTPVYNINAHSGASCSSISFSNLKSNLMA-SVGSD--SCVRLW 405
                 56789****************99999999999******99988.22222..458888 PP

>> ELYS-bb  beta-propeller of ELYS nucleoporin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0    0.0095        28     222     279 ..     241     297 ..     205     313 .. 0.83
   2 ?    7.1   0.0   0.00061       1.8     206     272 ..     363     432 ..     357     441 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.0095
     ELYS-bb 222 avsalsyisrtnqlavgfsdgylslwnlktlkkeyhsqleggrvpvyavifqependp 279
                 a+ ++s+ s   +la g  d  + +w+l   k  ++    +g  p+ +v f   e++ 
  EFC37542.1 241 AILSMSFRSSDSKLASGSDDKSIVIWDLSNQKP-FYQVKGAGASPIQSVQFHHTEQNI 297
                 4556778888899***************88665.5545577999*******9998765 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.00061
     ELYS-bb 206 regrhlclqlaspsgvavsalsyis.rtnqlavgfsdgylslwnlktlkke..yhsqleggrvpvyavif 272
                 r+ +  ++++++ sg + s++s+ + ++n +a   sd  ++lwn kt   e  y  ++++    +y+  f
  EFC37542.1 363 RNEKTPVYNINAHSGASCSSISFSNlKSNLMASVGSDSCVRLWNTKTSTPElvYTKNVKKSMSDIYSCAF 432
                 666667788999**********9874788888888***********987764466666666666666665 PP

>> DUF5520  Family of unknown function (DUF5520)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.5   3.2e-05     0.097     203     275 ..      42     118 ..      36     124 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.2e-05
     DUF5520 203 lsrgelgpvakdkaseeeddsdtdsaddakqeekgeaeskttk...rreikln.vvfkseeskkclvshrndrkpfl 275
                 l+ +   p +  k ++++dd+d+++ d   +++ + +e++t+k    +ei+l+ +++ks   k+  ++++n++ p+l
  EFC37542.1  42 LADSMTEPPKDPKEQQDDDDEDNEMEDSEMNDDEQVEEEETSKiggLEEISLEeLLYKSVGGKNLTMYENNEQDPYL 118
                 5555556666778888888888887776655555555545554222589*9963899***************99998 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2  10.6    0.0031       9.1     649     702 ..      54     110 ..      33     137 .. 0.48

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.0031
  DNA_pol_phi 649 eeeeeeddeededseedddeeesdedeededdedvdeid..elreklaealgesg....e 702
                  +e++++dde++e ++++++++e+ e+ee+++ +     +   l+e l +  g ++    e
   EFC37542.1  54 KEQQDDDDEDNEMEDSEMNDDEQVEEEETSKIGGL---EeiSLEELLYKSVGGKNltmyE 110
                  22222222222222222222333333333333333...2447777777777777744441 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (466 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       824  (0.0459591); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.43
# Mc/sec: 3237.89
//
Query:       EFC37543.1  [L=347]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.4e-18   64.2   0.7    3.3e-16   59.3   0.3    2.2  2  BACK      BTB And C-terminal Kelch
    7.2e-07   29.2   6.8    1.5e-06   28.2   6.8    1.6  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
    2.1e-05   24.7   0.0    4.6e-05   23.6   0.0    1.6  1  BTB       BTB/POZ domain
  ------ inclusion threshold ------
       0.47   10.5   3.5          1    9.4   3.5    1.6  1  HypA      Hydrogenase/urease nickel incorporation, metallocha
        7.5    6.7   6.2        5.7    7.1   3.2    2.3  3  FeoC      FeoC like transcriptional regulator


Domain annotation for each model (and alignments):
>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.029     1e+02       2      26 ..      86     110 ..      85     116 .. 0.89
   2 !   59.3   0.3   9.1e-20   3.3e-16      13     100 ..     133     221 ..     125     223 .. 0.94

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.029
        BACK   2 lgilefAeaysceeLaeaakefilk 26 
                 ++++ fA++y+++e++ +a +++++
  EFC37543.1  86 MDLYTFAHTYGMQEIEGRALKIMRS 110
                 57899**************999986 PP

  == domain 2  score: 59.3 bits;  conditional E-value: 9.1e-20
        BACK  13 ceeLaeaakefilknfeevlkseeFleLskeqllellssdeLn.vesEeevfeavlkWvkhdeeerkkhlpelLekvRlpllspeyLke 100
                 +++L+++  + i +nf++v++se F++Ls e+l+ +l+ +eL+ + sE ++f+ +++W++hd+e+r ++l   L+ +R+p+++ e+L +
  EFC37543.1 133 INSLKKTLLTKISANFDAVCESEHFVKLSIEDLKVMLAGEELKlIGSEGNLFKSLMRWIEHDKENRLQYLDYFLSEIRFPIIEGEVLAT 221
                 678999************************************9468************************************9998875 PP

>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   6.8   4.1e-10   1.5e-06       2      31 ..     313     341 ..     312     347 .] 0.94

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 4.1e-10
                 S-HHHHHCT---STSSSS-HHHHHCTHHHC CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCt 31 
                 +Cd+Crk +v C  +kP C +C+kl+++C+
  EFC37543.1 313 PCDQCRKAHVFCTDEKP-CPRCVKLGFQCV 341
                 7****************.***********8 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   0.0   1.3e-08   4.6e-05       5     100 ..       8     101 ..       4     111 .. 0.89

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 1.3e-08
                 HHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHH CS
         BTB   5 resgelcDvtlvvgdgkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlk 100
                    +e +D++l  ++gk+f+a +a +   S+ +k+l+    + + +++ + ld+v+   +e++L+++Y g ++    ++ ++l + a+ + ++++ 
  EFC37543.1   8 YLDEEVSDCVLISQNGKKFPALRAMVGKWSTKLKELLFIP-EFKIGME-LVLDQVTDLGLEIFLKVVYFGSTKDYAVDKFMDLYTFAHTYGMQEIE 101
                 556799**********************************.7888865.99*******************99998789999*********999886 PP

>> HypA  Hydrogenase/urease nickel incorporation, metallochaperone, hypA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   3.5   0.00029         1      66     105 ..     307     346 ..     286     347 .] 0.82

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00029
                 EE--EEEETTTS-EEECHHHHHS-TTTSSS-EEEEESSSE CS
        HypA  66 evpvkvrCreCgkefeleekalrCpkCgsadveivsGeel 105
                 + +vk  C++C+k     +++  Cp+C + ++++v+G+ l
  EFC37543.1 307 RNQVKSPCDQCRKAHVFCTDEKPCPRCVKLGFQCVGGKSL 346
                 6788999*****88885556678**************987 PP

>> FeoC  FeoC like transcriptional regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.1   3.8e+03      30      41 ..      28      39 ..      23      39 .. 0.85
   2 ?   -2.9   0.0         2   7.2e+03      11      35 ..     142     169 ..     133     170 .. 0.52
   3 ?    7.1   3.2    0.0016       5.7      40      64 ..     297     321 ..     288     333 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.1
        FeoC 30 aleamLeqwvrk 41
                al+am+  w  k
  EFC37543.1 28 ALRAMVGKWSTK 39
                79*******776 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2
        FeoC  11 ergrvslkeLs..rhf.kaspealeamL 35 
                 ++ +++++  +   hf k s e l+ mL
  EFC37543.1 142 TKISANFDAVCesEHFvKLSIEDLKVML 169
                 4455555555311344355666677776 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0016
        FeoC  40 rkGrvekvaataccsgsCkkCggke 64 
                  kG v+k+++ ++ ++ C +C +++
  EFC37543.1 297 DKGEVTKKKRRNQVKSPCDQCRKAH 321
                 59*******************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       594  (0.0331307); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.52u 0.24s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 2356.38
//
Query:       EFC37544.1  [L=1046]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.3e-49  166.8   0.0      2e-48  165.0   0.0    1.9  1  Pkinase_Tyr  Protein tyrosine kinase
    2.7e-44  151.5   0.0      5e-44  150.6   0.0    1.4  1  Pkinase      Protein kinase domain
    3.8e-09   36.6  22.6    6.3e-06   26.1   6.1    3.9  3  Beta_helix   Right handed beta helix region
    8.9e-08   32.2  19.3      0.059   13.9   1.1    6.3  5  Chlam_PMP    Chlamydia polymorphic membrane protein (Chlamydi
    0.00094   19.2   0.0     0.0016   18.4   0.0    1.3  1  APH          Phosphotransferase enzyme family
  ------ inclusion threshold ------
          5    8.2  17.4          2    9.5   1.8    4.5  4  DUF5123      Domain of unknown function (DUF5123)


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  165.0   0.0   6.6e-52     2e-48       1     259 []     732    1033 ..     732    1033 .. 0.89

  Alignments for each domain:
  == domain 1  score: 165.0 bits;  conditional E-value: 6.6e-52
                   EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH.HHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr    1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateee.keelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk 95  
                   le+ kk+ eG  G V+++ l      ke++VavK+lk+ a++ee + e+ +ea+i+ +l+h ni+k++gvc+ +e+ ++vte++++G+L+  + + 
   EFC37544.1  732 LEIVKKISEGGQGVVYKAILF-----KETSVAVKSLKNLADDEElQLEFEKEASILASLQHANILKFYGVCITDETRYMVTEFLENGSLERLIFNC 822 
                   57899****************.....99**********999998788*******************************************988654 PP

                   ..CTTTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE...... CS
  Pkinase_Tyr   96 ..ekekltlkdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk...... 181 
                      k++lt+++++ + +++A+Gm+yL+s +  ++Hrdl   NvLl+e+  +ki+DfGL+r++  + ++++ +++   + + +pE +++++      
   EFC37544.1  823 rnGKTNLTFQQKILLLQDIAAGMDYLHSLQpaIIHRDLKPGNVLLDEDLRCKICDFGLSRSV-GNLTQNTMTRGIGTLFYASPELMRNEQeltnds 917 
                   227999*********************987779*****************************.444555667788999**********999***** PP

                   ..........EEHHHHHHHHHHHHHHHHTTSSGT.........................TTTSHHHHHHHHHHTTEES-BBTTSBH....HHHHHH CS
  Pkinase_Tyr  182 ..........ftsksDvWsfGvllwEiftlgesp.........................ypglkneevleklkegkrlekpekcpe....elyelm 238 
                               +k Dv+sfG+++wE+f    +p                         y+ l + e++e l+e  ++   +++++    e   l 
   EFC37544.1  918 leisheskisRATKMDVYSFGIIMWELFF-ELTPytvsskvganaslapvnvlgmvlngYRPLVPFETIEELQEWLNMYPVSNMNPvailEYFILA 1012
                   ****99998888999************98.445568999********************9999999999999887777655554432111556678 PP

                   HHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  239 kkcweedpeeRptfselvekl 259 
                   k+cw+++ + Rp+fs ++++l
   EFC37544.1 1013 KQCWNQQTDLRPSFSIIRSEL 1033
                   9**************998876 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  150.6   0.0   1.7e-47     5e-44       2     255 ..     733    1026 ..     732    1033 .. 0.82

  Alignments for each domain:
  == domain 1  score: 150.6 bits;  conditional E-value: 1.7e-47
                  EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS CS
     Pkinase    2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgs 94  
                  e ++k+ eG+ G+Vyka+   ++  vAvK +k+  ++++ + ++ +E +il++l+h ni+++y+v+ +++++y+v+e++e+g+l++l+      k++
  EFC37544.1  733 EIVKKISEGGQGVVYKAI-LFKETSVAVKSLKNLADDEELQLEFEKEASILASLQHANILKFYGVCITDETRYMVTEFLENGSLERLIFncrnGKTN 828 
                  57899*************.79999*****************9*******************************************999888655566 PP

                  --HHHHHHHHHHHHHHHHHHHHTT..EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH..............TTSC CS
     Pkinase   95 lseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl..............kene 173 
                  l+ ++   +++ i++g++ylHs +  iiHrDlKp N+L+de+   Ki+DFGl++ + + ++  +t  +gt  Y +PE++              +e++
  EFC37544.1  829 LTFQQKILLLQDIAAGMDYLHSLQpaIIHRDLKPGNVLLDEDLRCKICDFGLSRSVGNLTQntMTRGIGTLFYASPELMrneqeltndsleisHESK 925 
                  899999999************88777******************************99888889***************998888887777763344 PP

                  B..SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT........SHH...HHHTTS..........-HHHHHHHHHHT-SSGC CS
     Pkinase  174 y..skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg........etkeklpeasei..........seeakdllkkllkkdpk 250 
                  +   +k+Dv+s G+i++el+++ +p+   ++k  +++ l  +  + ++l+        et e+l+e+ ++            e   l k++++++  
  EFC37544.1  926 IsrATKMDVYSFGIIMWELFFELTPYT-VSSKVGANASLAPVNVLGMVLNgyrplvpfETIEELQEWLNMypvsnmnpvaILEYFILAKQCWNQQTD 1021
                  434789********************9.444444555555555555666566555554334444444444666666666655556677777777777 PP

                  CSTTH CS
     Pkinase  251 kRlta 255 
                   R+++
  EFC37544.1 1022 LRPSF 1026
                  77765 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   9.7    0.0035        10      10     138 ..      64     197 ..      35     244 .. 0.68
   2 !   19.5   0.6   2.3e-07    0.0007      27     149 ..     226     379 ..     202     392 .. 0.69
   3 !   26.1   6.1   2.1e-09   6.3e-06       2     123 ..     344     494 ..     343     518 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0035
                 E.EEESEEEES-SS-SEEE-SSS-.EEES-EEES.....-SS-SEEE-TT-S-EEES-EEE---..SEEE-TT.--S--EEES-EEES-SS-SEE-TT- CS
  Beta_helix  10 nvtiknntisnsggyGiylrgssnvvienneian.....nsgsGiyilgssnntisnntisdnn..gggialf.gasnnlienneitdnggsGiylnys 100
                 n+ i+n+ i++s++ G+ l + + v +  +++++       +s++yi + + n i+ ++i +++  ++ +++  g+++  ++ ++i  + +  i++++s
  EFC37544.1  64 NIGIENVRIYDSYAKGFLLSNVKIVNLI-SDFTSlnlfiLEYSNVYIFKFTTNSIQLSRIDNSKilYFTMNILiGTKQDKLYISNIQSTQSFIINTEQS 161
                 4568899999999999999999985555.5666655666677777777778888888888888888666666666666666666666666666666666 PP

                 S--EEES-EEESTT--SEE---TT---EEES-EEES-S CS
  Beta_helix 101 snntienNiidnnagsGividdsssnvtvtnNtitnnk 138
                 s +++ n+i+++   + ++i+  + n+ ++n+t++ ++
  EFC37544.1 162 SLLSLYNSIFEETL-AFFSISFAD-NILIENCTFSVAM 197
                 66666666666666.666666666.7777777776555 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 2.3e-07
                 EE-SSS-.EEES-EEES.......-SS-SEEE-TT...............-S-EEES-EEE---...SEEE-TT--S--EEES-EEES-SS-SEE-TT. CS
  Beta_helix  27 ylrgssnvvienneian.......nsgsGiyilgs...............snntisnntisdnn...gggialfgasnnlienneitdnggsGiylny. 99 
                  +r s+nv +e++ei++       +++       +               +   + n+++  n+   ++ ++l++  +  i+ +++t+  gs iy+++ 
  EFC37544.1 226 SIRISTNVEFESCEISSsssfstlSYD-------TeflityqapvslfvvDTLRVMNSKFDSNKgerASTFYLSDILKFYIKESNFTRGLGSPIYIDSm 317
                 566677888888888885555555333.......33333333666555556666667777666677778999999999999999999999999999966 PP

                 -S-.....-EEES-EEESTT....--SEE---TT....---EEES-EEES-SSEEEE-TT-SS CS
  Beta_helix 100 ssn.....ntienNiidnna....gsGividdss....snvtvtnNtitnnkgaGiavvgsss 149
                 ++      + ien+ + +n+    g +i+i+ ++    sn+ ++nNt+++++  +i++ g  +
  EFC37544.1 318 AKEtklvvTLIENSLFQDNYspnlGGAIFISTTQsleiSNTIFRNNTAKKSG-GAIFILGATD 379
                 4444567777899999999999999999999999777666666666666665.6676665554 PP

  == domain 3  score: 26.1 bits;  conditional E-value: 2.1e-09
                 SEEE-SS-E.EEESEEEES-....SS-SEEE-SSS-......EEES-EEES...-SS-SEEE-TT................-S-EEES-EEE---SEEE CS
  Beta_helix   2 gisingssnvtiknntisns....ggyGiylrgssn.....vvienneian...nsgsGiyilgs................snntisnntisdnngggi 72 
                 +i+i+ +++++i+n +++n+    +g +i++ g+++      ++ +n++++     ++ iy+ ++                +n+t++ n+ ++++  ++
  EFC37544.1 344 AIFISTTQSLEISNTIFRNNtakkSGGAIFILGATDlsltgSLFYGNRVTYsnsLPTDKIYMGNGgaifilsslsvdslsiKNATFESNYAYNGG--AL 440
                 6899999999999999999999999***********8888777777777778885666666666677777777***8888888888888888666..77 PP

                 -TT--S--EEES-EEES-.....SS-SEE-TT-S--EEES-EEESTT--SEE---T CS
  Beta_helix  73 alfgasnnlienneitdn.....ggsGiylnyssnntienNiidnnagsGividds 123
                  + +     i+++++++n     gg  iy ++   ++++nN++ +n+ + i+ dd 
  EFC37544.1 441 FYWKEALASIRDCTFRNNraqraGG-AIYQFQKAETSLTNNRFIGNR-ADIFGDDY 494
                 7778888999999999997777344.89998999*************.66665554 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0025       7.6       2      27 ..     331     347 ..     278     348 .. 0.90
   2 !   13.9   1.1     2e-05     0.059       1      26 [.     357     373 ..     357     374 .. 0.92
   3 ?    2.0   0.4      0.12   3.6e+02      20      26 ..     406     412 ..     405     413 .. 0.90
   4 ?    4.8   1.3     0.016        47       1      26 [.     426     441 ..     426     441 .. 0.91
   5 !   12.0   0.0   7.8e-05      0.23       1      26 [.     452     468 ..     452     468 .. 0.96

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0025
   Chlam_PMP   2 itFsnNtatvsstptpaaggGGAIya 27 
                  +F +N +         ++ GGAI+ 
  EFC37544.1 331 SLFQDNYS---------PNLGGAIFI 347
                 46888888.........*******95 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 2e-05
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAIy 26 
                 +++F nNta          ++GGAI+
  EFC37544.1 357 NTIFRNNTA---------KKSGGAIF 373
                 579******.........*******9 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.12
   Chlam_PMP  20 ggGGAIy 26 
                 g+GGAI+
  EFC37544.1 406 GNGGAIF 412
                 89****9 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.016
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAIy 26 
                 + tF++N a           +GGA++
  EFC37544.1 426 NATFESNYA----------YNGGALF 441
                 579******..........*****97 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 7.8e-05
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAIy 26 
                 ++tF nN a            GGAIy
  EFC37544.1 452 DCTFRNNRA---------QRAGGAIY 468
                 69*******.........*******9 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   5.4e-07    0.0016     140     195 ..     829     880 ..     756     883 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 5.4e-07
                 CTCCHHHHHHHHHHHHHHHH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT CS
         APH 140 elldlleeleeqvlaalaallpgelptvllHgDlhpgNllvdpddgrvtGviDfed 195
                 ++++ +  l  q +aa  + l+ +l++ ++H+Dl+pgN+l+d +d r+  + Df++
  EFC37544.1 829 LTFQ-QKILLLQDIAAGMDYLH-SLQPAIIHRDLKPGNVLLD-EDLRC-KICDFGL 880
                 4444.23333333333334444.47779**************.77776.5667765 PP

>> DUF5123  Domain of unknown function (DUF5123)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.9      0.65   1.9e+03      21      64 ..     123     163 ..      97     182 .. 0.64
   2 ?    2.2   0.1      0.12   3.7e+02       1      21 [.     186     206 ..     186     261 .. 0.71
   3 ?    4.6   0.2     0.023        68      30      73 ..     326     369 ..     285     416 .. 0.65
   4 ?    9.5   1.8   0.00067         2       2     101 ..     449     552 ..     448     559 .. 0.69

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.65
     DUF5123  21 dkkttssstltvtnnif.kktvneatagtlratknltvkfsnnny 64 
                 d     s+ l +t ni+  +++++ ++ ++++t+  ++++++ + 
  EFC37544.1 123 D----NSKILYFTMNILiGTKQDKLYISNIQSTQSFIINTEQSSL 163
                 3....4566777777776666677777777777777777666554 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.12
     DUF5123   1 vtiencTfyntnansgllfvd 21 
                 + iencTf+ ++++  ++++ 
  EFC37544.1 186 ILIENCTFSVAMKSDPVFVIA 206
                 579*****9955555555554 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.023
     DUF5123  30 ltvtnnifkktvneatagtlratknltvkfsnnnyltsdfesss 73 
                   ++n++f+++ + + +g ++ +++++ + sn  ++++ +++s+
  EFC37544.1 326 TLIENSLFQDNYSPNLGGAIFISTTQSLEISNTIFRNNTAKKSG 369
                 45555555555555555555555555555555555553333333 PP

  == domain 4  score: 9.5 bits;  conditional E-value: 0.00067
     DUF5123   2 tiencTfyn...tnansgllfvdkkttssstltvtnnif....kktvneatagtlratknltvkfsnnnylt.s.dfesssekeaatnataltsdplFk 91 
                 +i++cTf n   +    g  + +   +++ + ++tnn f    ++ + +++    ++ + ++ ++++ +yl    ++  s+ +++       ++d++++
  EFC37544.1 449 SIRDCTFRNnraQ--RAGGAIYQ---FQKAETSLTNNRFignrADIFGDDYFLLENSLSLNSSNYGQFYYLYpGqQVFISAMATSSEMVIPVNVDNMYV 542
                 699******5322..23333333...4567888999988888656666777777777777788888888888534444444444444499999****** PP

     DUF5123  92 dpangDFtit 101
                 ++ n D+t+ 
  EFC37544.1 543 NVTNPDYTFI 552
                 ********86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1046 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       771  (0.043003); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.88u 0.36s 00:00:01.24 Elapsed: 00:00:00.54
# Mc/sec: 5813.27
//
Query:       EFC37545.1  [L=927]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    7.5e-14   52.0   2.6    7.5e-14   52.0   2.6    2.7  3  RGS         Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.056   13.8   0.3       0.27   11.6   0.1    2.3  2  DUF1935     Domain of unknown function (DUF1935)


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.0   2.6   8.4e-18   7.5e-14       2      82 ..     414     494 ..     413     523 .. 0.88
   2 ?   -1.7   0.4      0.38   3.4e+03     115     115 ..     741     741 ..     666     803 .. 0.70
   3 ?   -2.0   0.4      0.45     4e+03      18      18 ..     762     762 ..     725     824 .. 0.58

  Alignments for each domain:
  == domain 1  score: 52.0 bits;  conditional E-value: 8.4e-18
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCS CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlek 82 
                 +e+++++++++slFr Fle+e+s enl+F+++v  +k++++  ++ kk +eI+++yl++ss++ lni++++ e+ e+  +k
  EFC37545.1 414 FENMFNNPTLLSLFRIFLEKEKSAENLAFLEEVRAYKSTSTTIDRGKKQQEIISKYLEKSSNTFLNISHAVYETEESIGKK 494
                 899*******************************************************************99765444333 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.38
                 H CS
         RGS 115 y 115
                 +
  EFC37545.1 741 F 741
                 2 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.45
                 H CS
         RGS  18 F 18 
                 F
  EFC37545.1 762 F 762
                 3 PP

>> DUF1935  Domain of unknown function (DUF1935)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.3   1.1e+04      12      33 ..     415     436 ..     409     463 .. 0.68
   2 ?   11.6   0.1     3e-05      0.27      31      67 ..     841     877 ..     817     893 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.3
                 EE-STT....SEEEEEETTTTE CS
     DUF1935  12 tkcfkesgnglLfrivdekekr 33 
                  ++f++     Lfri  ekek+
  EFC37545.1 415 ENMFNNPTLLSLFRIFLEKEKS 436
                 5667666556789998887543 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 3e-05
                 TTEEEEEE--SSEEEEEEEEEETT-EEEE-TT-EEEE CS
     DUF1935  31 ekrWaFYNDtkdyemkvtvsfgpksevkalgkttvee 67 
                 +++W FYN + + ++kv+v + + +ev+ l + +  +
  EFC37545.1 841 SNEWIFYNQSLNRRVKVEVLVLCMEEVNSLVALEHRT 877
                 578*****************99999988665444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (927 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1077  (0.0600703); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.50
# Mc/sec: 5525.18
//
Query:       EFC37546.1  [L=367]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.8e-09   35.3   0.2       0.15   12.2   0.0    5.4  4  LRR_6       Leucine Rich repeat
  ------ inclusion threshold ------
      0.014   15.2   0.1      0.031   14.2   0.1    1.5  1  F-box-like  F-box-like
      0.036   14.5   6.3        6.9    7.2   0.0    5.1  5  LRR_4       Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.0   3.5e-05      0.21       3      24 .]     214     235 ..     214     235 .. 0.93
   2 ?    3.0   0.0     0.021   1.3e+02       3      20 ..     241     258 ..     239     259 .. 0.91
   3 !   12.2   0.0   2.5e-05      0.15       4      24 .]     269     289 ..     266     289 .. 0.91
   4 ?    0.8   0.2      0.11   6.6e+02       3      12 ..     295     304 ..     293     306 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.5e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt Ld+    Ig+eG++ +a
  EFC37546.1 214 SNLTDLDIGMTSIGNEGMKYFA 235
                 68****************9876 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.021
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                  +L+ L L  + ++ eG+
  EFC37546.1 241 KKLKRLILDRCSFDAEGV 258
                 58***************8 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 2.5e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +++eL+  + dIgDeG++ La
  EFC37546.1 269 SIEELEFEYTDIGDEGVKYLA 289
                 6899**************997 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.11
       LRR_6   3 thLteLdLsg 12 
                  +Lt Ld++ 
  EFC37546.1 295 KNLTRLDITR 304
                 68*****986 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.1   5.2e-06     0.031       6      36 ..      16      47 ..      16      50 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 5.2e-06
  F-box-like  6 dEiLlqIFsyLppsdLlr.lalVCrrWrrval 36
                d+ L  IF++ ++s+L++ ++ +C+rW r+al
  EFC37546.1 16 DDMLTNIFQFCSLSQLISeIMPTCKRWFRIAL 47
                578999***99*******9***********96 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.068   4.1e+02      10      30 ..      90     110 ..      86     118 .. 0.85
   2 ?   -0.8   0.1       0.4   2.4e+03      28      28 ..     166     166 ..     131     201 .. 0.61
   3 ?    3.8   0.0     0.014        82      19      36 ..     211     226 ..     195     230 .. 0.78
   4 ?    1.8   0.1     0.059   3.5e+02       2      30 ..     215     248 ..     214     255 .. 0.48
   5 ?    7.2   0.0    0.0012       6.9      18      33 ..     291     305 ..     270     327 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.068
                 SS---E-S-HHH-TT--EEE- CS
       LRR_4  10 nNqltdiplleklpnLkeLdL 30 
                  N++  + +++++++Lk+L +
  EFC37546.1  90 RNHVEILVNCGSFKKLKTLAI 110
                 689999999999******966 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.4
                 E CS
       LRR_4  28 L 28 
                 L
  EFC37546.1 166 L 166
                 2 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.014
                 HHH-TT--EEE-.-S--- CS
       LRR_4  19 leklpnLkeLdLsgNnli 36 
                 ++ + nL+ Ld+ g++ i
  EFC37546.1 211 PN-FSNLTDLDI-GMTSI 226
                 55.99******9.87444 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.059
                 S--EEE--SS---E-S-..HH...H-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdL 30 
                 nL+ Ld++ + +   +   ++    l++Lk L L
  EFC37546.1 215 NLTDLDIGMTSIGNEGMkyFAsspYLKKLKRLIL 248
                 5555555544444222244222323777777765 PP

  == domain 5  score: 7.2 bits;  conditional E-value: 0.0012
                 -HHH-TT--EEE-.-S CS
       LRR_4  18 lleklpnLkeLdLsgN 33 
                 +++ ++nL+ Ld+++ 
  EFC37546.1 291 SPN-MKNLTRLDITRT 305
                 355.*********553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (367 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       446  (0.0248759); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2187.61
//
Query:       EFC37547.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.8e-33  114.3   0.0    8.9e-33  113.7   0.0    1.3  1  ABC_tran     ABC transporter
    9.7e-08   31.7   0.7    6.3e-05   22.5   0.1    2.2  2  SMC_N        RecF/RecN/SMC N terminal domain
    9.8e-06   26.1   0.0    2.4e-05   24.8   0.0    1.6  1  AAA_16       AAA ATPase domain
    0.00028   20.6   0.1    0.00062   19.4   0.1    1.6  1  AAA_29       P-loop containing region of AAA domain
    0.00074   19.7   1.1      0.065   13.3   0.1    2.2  2  DUF87        Helicase HerA, central domain
     0.0013   19.0   0.1     0.0064   16.8   0.1    1.9  1  AAA_22       AAA domain
     0.0023   18.4   0.5      0.034   14.6   0.5    2.2  1  AAA          ATPase family associated with various cellular a
     0.0062   16.3   0.0      0.016   15.0   0.0    1.7  1  AAA_30       AAA domain
     0.0082   16.1   0.0       0.03   14.2   0.0    1.9  2  RsgA_GTPase  RsgA GTPase
  ------ inclusion threshold ------
      0.013   15.2   0.0      0.026   14.3   0.0    1.3  1  AAA_15       AAA ATPase domain
      0.028   14.4   0.1       0.14   12.2   0.0    2.1  2  AAA_5        AAA domain (dynein-related subfamily)
      0.049   12.4   0.1       0.11   11.3   0.0    1.6  2  ABC_ATPase   Predicted ATPase of the ABC class
      0.057   12.9   0.0       0.11   12.1   0.0    1.4  1  AAA_7        P-loop containing dynein motor region
       0.15   12.6   0.4       0.32   11.5   0.0    1.7  2  AAA_23       AAA domain
       0.19   11.0   0.0       0.51    9.6   0.0    1.7  2  Zeta_toxin   Zeta toxin


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.7   0.0   7.4e-36   8.9e-33       1     137 []     128     279 ..     128     279 .. 0.90

  Alignments for each domain:
  == domain 1  score: 113.7 bits;  conditional E-value: 7.4e-36
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH..................HH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren..................es 81 
                 lk+ sl++k+g+ va+vG++G+GKSt++ l+ + ++p++G+il+dg d+ e++  + +++ig+++qep lf  + ++en                  ++
  EFC37547.1 128 LKDFSLDIKQGQSVALVGPSGSGKSTIVGLVEKFYNPNAGQILIDGVDILEIDPMFIHHKIGIVTQEPVLFAAS-IKENiayavglenvtheqivnaAK 225
                 799***********************************************************************.**********88766665554444 PP

                 HTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  82 deeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                  +++++++  l +++  dt +++++ s+SgGqkqr+a+aral+++p +lllDE+t+
  EFC37547.1 226 LANCHNFIMDLPDEY--DTLLGEKGVSMSGGQKQRIAIARALIQNPIVLLLDEATS 279
                 444666666655555..999**********************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.1    0.0017         2      25      41 ..     139     155 ..     127     161 .. 0.80
   2 !   22.5   0.1   5.3e-08   6.3e-05     136     211 ..     250     321 ..     170     329 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0017
                 SEEEEEESTTSSHHHHH CS
                 xxxxxxxxxxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnll 41 
                 +  a+vGp GSGKs ++
  EFC37547.1 139 QSVALVGPSGSGKSTIV 155
                 34689*********997 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 5.3e-08
                 CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreemlekadklvgv 211
                 ++SgG+k+ +a+a  +    ++   + llDe  +aLD +  + v e l++  k    i+i++r  +++++d ++ +
  EFC37547.1 250 SMSGGQKQRIAIARAL----IQNPIVLLLDEATSALDTESEALVQEALDNLMKGRTTICIAHRLSTIKNSDVICVL 321
                 79******99887542....344445689****************************************9987655 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   0.0     2e-08   2.4e-05      23     162 ..     137     296 ..     126     306 .. 0.58

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 2e-08
      AAA_16  23 rpelvllsGesGvGKsslvrellralekd.....................ggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawrek 100
                 ++++v l+G+sG+GKs++v  + + ++ +                     ++  ++++ + +         a  + +e +  +++ e  + e+   ++k
  EFC37547.1 137 QGQSVALVGPSGSGKSTIVGLVEKFYNPNagqilidgvdileidpmfihhKIGIVTQEPVLF---------AASI-KENIAYAVGLENVTHEQIVNAAK 225
                 4589***************9999999999666777777777776665554333444444444.........3333.22333333333222222222222 PP

      AAA_16 101 leeala...............avpelagaeasrllellkrllallsrderplvlvlDdlq.wadeaslqllaaLlrll 162
                 l    +                + +++g +++r++ + ++l+      + p+vl+lD++   +d++s +l ++ l++l
  EFC37547.1 226 LANCHNfimdlpdeydtllgeKGVSMSGGQKQRIAIA-RALI------QNPIVLLLDEATsALDTESEALVQEALDNL 296
                 2222223333333222443344444555544444444.3333......789*******99667778888888877764 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.1   5.2e-07   0.00062      16      39 ..     132     155 ..     124     165 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 5.2e-07
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                 +++i++ +++ l+GpsGsGKST++
  EFC37547.1 132 SLDIKQGQSVALVGPSGSGKSTIV 155
                 566774449*************98 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.1   5.4e-05     0.065      16      59 ..     133     172 ..     125     174 .. 0.83
   2 ?    5.1   0.1     0.018        21      50     135 ..     226     301 ..     215     373 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.4e-05
       DUF87  16 ldlnklvtrHlAilgsTGsGKSntvavLleellekkgatililD 59 
                 ld+++   +++A +g +GsGKS+ v+ L+e+ +  ++a  +++D
  EFC37547.1 133 LDIKQ--GQSVALVGPSGSGKSTIVG-LVEKFY-NPNAGQILID 172
                 66644..4899**************9.799999.8888777777 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.018
       DUF87  50 kkgatililDpHGEYgkalekllsekvkvitpspsakdkelkinpwsldpeelldlleeddkpaaavqrsvleealdqakakeeke 135
                   + +  i D   EY ++l     ek + ++     +++++ i  ++l  + ++ ll+e + ++ ++++++++eald++ +   ++
  EFC37547.1 226 LANCHNFIMDLPDEYDTLL----GEKGVSMSGG---QKQRIAIA-RALIQNPIVLLLDEATSALDTESEALVQEALDNLMK--GRT 301
                 567799*************....7777777765...45666664.455667788888887777777899999999998874..333 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   5.3e-06    0.0064       4     107 ..     137     291 ..     133     306 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 5.3e-06
      AAA_22   4 tagilvvtGesGtGKTtllrrlleqldeeakaee..............erpevvfvtlpsstsskdllrellralglelka.................. 70 
                 + ++++++G+sG+GK+t +  + + ++  a +                +++  +  + p++   +++ ++++ a+gle+ +                  
  EFC37547.1 137 QGQSVALVGPSGSGKSTIVGLVEKFYNPNAGQILidgvdileidpmfiHHKIGIVTQEPVLF-AASIKENIAYAVGLENVTheqivnaaklanchnfim 234
                 78999**************9999999765555558889999998888866666666666666.777777777777777777777777777777777777 PP

      AAA_22  71 ..........erlsseellealeqalrarav...ielliiDEaqh.lr..s....ee 107
                            ++  +    + ++ + ara    + +l++DEa   l+  s    +e
  EFC37547.1 235 dlpdeydtllGEKGVSMSGGQKQRIAIARALiqnPIVLLLDEATSaLDteSealvQE 291
                 777777766433444444466666666666677888999999988776653333344 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.5   2.8e-05     0.034       2     114 ..     142     311 ..     141     322 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.8e-05
                 EEESSTTSSHHHHHHHHHHHH..........THEEEEEETTTCSSS..................................................... CS
         AAA   2 llyGppGtGKTllakavakel..........gvefleisgsellsk..................................................... 37 
                  l+Gp G GK++++  v k            gv++lei+ + +  k                                                     
  EFC37547.1 142 ALVGPSGSGKSTIVGLVEKFYnpnagqilidGVDILEIDPMFIHHKigivtqepvlfaasikeniayavglenvtheqivnaaklanchnfimdlpdey 240
                 699***********9999997332222222334444444444444488888889999999999999999999999999999999999999999999999 PP

                 ........STTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEESSGGG CS
         AAA  38 ........yvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkkeskvivigatnrpdk 114
                         +   + +k r  +++a  ++ p +l++DE+ +   ++      +e  v+++L + ++g ++       i++++r ++
  EFC37547.1 241 dtllgekgVSMSGGQKQRIAIARALIQN-PIVLLLDEATSALDTE------SEALVQEALDNLMKGRTT-------ICIAHRLST 311
                 9999998766666777777777777776.9***********9999......677788888888887766.......555555544 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   1.3e-05     0.016      19     114 ..     139     294 ..     133     373 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.3e-05
      AAA_30  19 rvavltGpAGtGKttalkalreaweaa.g..........................grviglAptgkaAkvLaeelgieastiakllkrlk......... 81 
                 + ++l+Gp G+GK+t+++ +++ ++ + g                          ++v+ +A+ +   +++a ++g+e  t ++++++ k         
  EFC37547.1 139 QSVALVGPSGSGKSTIVGLVEKFYNPNaGqilidgvdileidpmfihhkigivtqEPVLFAASIK---ENIAYAVGLENVTHEQIVNAAKlanchnfim 234
                 46899*******************99956888888888888888888777776654444444322...2233333333333333333333333344777 PP

      AAA_30  82 ...........................grarlepgtllivDEagmvdtkqlaallkaaek 114
                                            +ra +++  +l+ DEa  +  ++ +al+++a +
  EFC37547.1 235 dlpdeydtllgekgvsmsggqkqriaiARALIQNPIVLLLDEATSALDTESEALVQEALD 294
                 777888888888888888888888777656666667888888877777777777777655 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.0   2.5e-05      0.03      80     118 ..     118     157 ..      89     171 .. 0.76
   2 ?   -2.0   0.0       2.4   2.9e+03      47      88 ..     179     219 ..     174     252 .. 0.49

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.5e-05
                  EE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHH CS
  RsgA_GTPase  80 llvsaktkegleelkellkd.ktsvlvGqSGvGKStLina 118
                  ++    +++ l++ +  +k+ + ++lvG+SG GKSt++  
   EFC37547.1 118 IYPARPNTTVLKDFSLDIKQgQSVALVGPSGSGKSTIVGL 157
                  55555556667777777777799*************9865 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.4
                  -EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTTHT CS
  RsgA_GTPase  47 iepvivlnKiDlleeeeeleelkeelealgyevllvsaktke 88 
                  i+p+ +  Ki ++++e  +   ++  e++ y+v l ++++++
   EFC37547.1 179 IDPMFIHHKIGIVTQEP-VLFAASIKENIAYAVGLENVTHEQ 219
                  55666666666666666.444444444454444444333222 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   2.1e-05     0.026      14      50 ..     128     165 ..     127     231 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.1e-05
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnk 50 
                 lkd+++d++      l+G+ +sGKS+i+ + ++F n +
  EFC37547.1 128 LKDFSLDIKQGqSVALVGPSGSGKSTIVGLVEKFYNPN 165
                 79999**99997889*******************9977 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   0.00011      0.14       2      25 ..     141     164 ..     140     172 .. 0.85
   2 ?   -1.2   0.0       1.6   1.9e+03      40      78 ..     242     281 ..     220     304 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00011
                 EEEE--SSSSHHHHHHHGGGGBS- CS
       AAA_5   2 vlLvGppGtgKselaerlaaalnr 25 
                 v LvGp+G+gKs+++  + +++n 
  EFC37547.1 141 VALVGPSGSGKSTIVGLVEKFYNP 164
                 78**************99999864 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.6
                 HHH--B--.........--------.G-SEEEEESGGG-- CS
       AAA_5  40 dlkgrreikngttslvdsplvraar.egeilvlDEverae 78 
                 +l+g+  +++++ + +  ++ ra   ++ +l+lDE + a 
  EFC37547.1 242 TLLGEKGVSMSGGQKQRIAIARALIqNPIVLLLDEATSAL 281
                 5555555554444444444444443377788888877664 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.3   1.6e+03     242     261 ..     135     155 ..     132     163 .. 0.80
   2 ?   11.3   0.0   9.1e-05      0.11     301     394 ..     228     322 ..     219     356 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.3
                 E-SS.EEEEEE-TTSSHHHHH CS
  ABC_ATPase 242 ipkG.vtlIvGggfhGKsTLL 261
                 i++G  +++vG+   GKsT++
  EFC37547.1 135 IKQGqSVALVGPSGSGKSTIV 155
                 8888767899*********86 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 9.1e-05
                 --TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS-HHH....H---HHHHHHS-GGG--B--HHHCHHHHHHHH--EEEEE CS
  ABC_ATPase 301 DispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsAtNl....mirDermqelvskekepitplvdrvrelykklgvstilv 394
                 +  +Fi +LP + dt         SG   q  +i++al  +  +lL+DE tsA       ++  e +++l+ k  ++  ++++r+  + k+ +v  +lv
  EFC37547.1 228 NCHNFIMDLPDEYDTLlGEKGVSMSGGQKQRIAIARALIQNPIVLLLDEATSALDTeseaLV-QEALDNLM-KG-RTTICIAHRLSTI-KNSDVICVLV 322
                 6789***********966666788*****************************643111133.34444444.22.2333555555555.5556656655 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   8.8e-05      0.11      29      51 ..     134     156 ..     121     170 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 8.8e-05
       AAA_7  29 llknkkpvllvGptGtGKtviik 51 
                  +k++++v lvGp+G+GK++i+ 
  EFC37547.1 134 DIKQGQSVALVGPSGSGKSTIVG 156
                 4799****************985 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00027      0.32      11      36 ..     129     155 ..     110     157 .. 0.82
   2 ?   -2.2   0.1         4   4.8e+03      91     114 ..     343     366 ..     279     374 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00027
      AAA_23  11 rdqeidFsk.gltlItGpNGaGKTTil 36 
                 +d+++d ++   ++++Gp G+GK+Ti+
  EFC37547.1 129 KDFSLDIKQgQSVALVGPSGSGKSTIV 155
                 55666664426889***********96 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 4
      AAA_23  91 ererelskkkgkttkkaklellei 114
                  r+  +++   k ++++++e l+i
  EFC37547.1 343 YRKLAEKQMAFKPKREDAEETLDI 366
                 223333333333333333333333 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00042      0.51      14      61 ..     136     183 ..     124     197 .. 0.83
   2 ?   -2.2   0.0       1.8   2.1e+03      76     101 ..     281     306 ..     275     325 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00042
  Zeta_toxin  14 erPklillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPey 61 
                 ++  ++ l+G +G+GKs++  l+++  +++ + + +d+ d+ e  P++
  EFC37547.1 136 KQGQSVALVGPSGSGKSTIVGLVEKFYNPNAGQILIDGVDILEIDPMF 183
                 55668899*****************99999999999988877777765 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.8
  Zeta_toxin  76 tqkdaselvekllqeaiengyniive 101
                  + ++  lv+++l+ +++ +  i + 
  EFC37547.1 281 LDTESEALVQEALDNLMKGRTTICIA 306
                 56677888899999999988887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      508  (0.028334); expected 358.6 (0.02)
Passed Vit filter:                        91  (0.00507558); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 2250.47
//
Query:       EFC37548.1  [L=778]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      1e-47  160.3   1.8    2.2e-47  159.2   1.8    1.6  1  RRM_2         RNA recognition motif 2
    4.7e-28   96.8   7.8    2.7e-12   46.3   0.5    3.8  3  RRM_1         RNA recognition motif. (a.k.a. RRM, RBD, or RNP
      4e-07   29.7   0.0    1.1e-05   25.0   0.0    2.6  2  RRM_5         RNA recognition motif. (a.k.a. RRM, RBD, or RNP
    4.5e-07   29.6   0.1     0.0063   16.4   0.0    2.5  2  RRM_occluded  Occluded RNA-recognition motif
     0.0071   16.5   1.6      0.071   13.3   0.3    2.6  2  BRAP2         BRCA1-associated protein 2
  ------ inclusion threshold ------
      0.016   15.2   0.1       0.71    9.9   0.0    2.6  2  Nup35_RRM_2   Nup53/35/40-type RNA recognition motif
      0.039   14.0   2.1      0.062   13.3   0.3    2.2  2  Smg4_UPF3     Smg-4/UPF3 family
      0.044   13.9   0.0       0.16   12.0   0.0    2.0  1  Limkain-b1    Limkain b1
       0.07   13.4   5.1         11    6.3   3.0    3.4  3  PHM7_cyt      Cytosolic domain of 10TM putative phosphate tra
      0.086   12.8   1.6        0.2   11.7   0.1    2.2  2  DbpA          DbpA RNA binding domain


Domain annotation for each model (and alignments):
>> RRM_2  RNA recognition motif 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  159.2   1.8   1.2e-50   2.2e-47       1      97 []     666     762 ..     666     762 .. 0.99

  Alignments for each domain:
  == domain 1  score: 159.2 bits;  conditional E-value: 1.2e-50
       RRM_2   1 rttlliknipnkytkkmllaaideknkgtydflylpidfknkcnvgyafinlvepkkivafqkafngkkwekfnsekvaslayariqgkaaliaklq 97 
                 rttl++knipnkyt+kmll+++d++ k  ydf+ylpidfknkcnvgyafin+ +pk i++f + fn kkwekfnsekv++++yariqgk ali+++q
  EFC37548.1 666 RTTLMVKNIPNKYTQKMLLETVDVEFKTAYDFFYLPIDFKNKCNVGYAFINFADPKLIIPFVERFNRKKWEKFNSEKVCDITYARIQGKIALINHFQ 762
                 8**********************************************************************************************98 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.0   0.0   6.9e-14   1.2e-10       1      69 [.     422     486 ..     422     487 .. 0.97
   2 !   46.3   0.5   1.5e-15   2.7e-12       1      70 []     508     574 ..     508     574 .. 0.91
   3 !   12.0   0.4   7.9e-05      0.14       1      63 [.     669     734 ..     669     740 .. 0.83

  Alignments for each domain:
  == domain 1  score: 41.0 bits;  conditional E-value: 6.9e-14
                 EEEESETTTSSHHHHHHHHHTTSCEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEE CS
       RRM_1   1 lfVgnLppdvteeeLkelFskfGpiksiklvrdetgkskgfafVeFeskedAekAlealngkklggrel 69 
                 lfV+n+++ v+++eL+ lF+ fGpi+    +++    ++gf  +++ + + A++A+++l+ k +++r++
  EFC37548.1 422 LFVRNISSVVDDQELRILFESFGPIRQMYTSCK----HRGFVMITYYDIRHAKQAKKNLQSKLIKKRKI 486
                 8*******************************5....*****************************998 PP

  == domain 2  score: 46.3 bits;  conditional E-value: 1.5e-15
                 EEEESETTTSSHHHHHHHHHTTS.CEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEEE CS
       RRM_1   1 lfVgnLppdvteeeLkelFskfG.piksiklvrdetgkskgfafVeFeskedAekAlealngkklggrelk 70 
                 l+V nL p++t+eeLk++F +fG ++k+i+  +    ++k + f+eF + +dAe+Al++ln+++l+g+++k
  EFC37548.1 508 LVVFNLDPSITNEELKTIFTQFGgDVKEIRETP----NKKFHKFIEFYDTRDAERALKQLNKTELKGKKIK 574
                 7899*****************752678888777....599999*************************996 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 7.9e-05
                 EEEESETTTSSHHHHHHH....HHTTSCEEEEEEEEE.TTTSEEEEEEEEESSHHHHHHHHHHHTTEE CS
       RRM_1   1 lfVgnLppdvteeeLkel....FskfGpiksiklvrd.etgkskgfafVeFeskedAekAlealngkk 63 
                 l+V+n+p+ +t+++L e     F+   ++  + l+ d +++ + g+af++F+++      +e++n+kk
  EFC37548.1 669 LMVKNIPNKYTQKMLLETvdveFKTAYDF--FYLPIDfKNKCNVGYAFINFADPKLIIPFVERFNRKK 734
                 78************999744446665555..89999*****************999888888888876 PP

>> RRM_5  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.097   1.7e+02      21      99 ..     414     491 ..     397     506 .. 0.82
   2 !   25.0   0.0   6.3e-09   1.1e-05      26     109 ..     505     588 ..     492     599 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.097
       RRM_5  21 agvaegsVllVyglepdkvnldklFnlfclYgnvervkflktkketalvqmgdasaveravqHLnnaklfgkrlevalS 99 
                  g   +  l+V ++  + v  ++l +lf  +g ++++      ++  ++   d +++++a + L+ + +  +++++  S
  EFC37548.1 414 PGEYPSRTLFVRNIS-SVVDDQELRILFESFGPIRQMYTSCKHRGFVMITYYDIRHAKQAKKNLQSKLIKKRKIDIHYS 491
                 555556667777775.568889999************99999***********************99998889999887 PP

  == domain 2  score: 25.0 bits;  conditional E-value: 6.3e-09
       RRM_5  26 gsVllVyglepdkvnldklFnlfclY.gnvervkflktkketalvqmgdasaveravqHLnnaklfgkrlevalSKqqavsekep 109
                 +  l+V +l+p+  + ++l  +f+++ g+v+ ++   +kk   +++  d++++era++ Ln ++l gk++++  S+   + +  p
  EFC37548.1 505 QETLVVFNLDPSI-TNEELKTIFTQFgGDVKEIRETPNKKFHKFIEFYDTRDAERALKQLNKTELKGKKIKIEYSRPGGLRNRFP 588
                 567899****985.557888899888469**********************************************9877765555 PP

>> RRM_occluded  Occluded RNA-recognition motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.7   0.0    0.0002      0.36       2      69 ..     420     487 ..     419     489 .. 0.92
   2 !   16.4   0.0   3.5e-06    0.0063       2      70 ..     506     575 ..     505     578 .. 0.94

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0002
  RRM_occluded   2 rtisllplsDtvnkariralveekegeikkivLvpdheG.AivefkdekiagkasLaLdgsefegkklr 69 
                   rt+ + ++s  v ++++r l+e+  g+i++++   +h+G  ++ + d ++a +a   L+++ ++++k+ 
    EFC37548.1 420 RTLFVRNISSVVDDQELRILFESF-GPIRQMYTSCKHRGfVMITYYDIRHAKQAKKNLQSKLIKKRKID 487
                   889999******************.**************446889999999999999999999999996 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 3.5e-06
  RRM_occluded   2 rtisllplsDtvnkariralveekegeikkivLvpdheG.AivefkdekiagkasLaLdgsefegkklrc 70 
                   +t+ +++l   ++++++++++++  g++k+i   p+++   ++ef d+++a +a+ +L+ +e++gkk+++
    EFC37548.1 506 ETLVVFNLDPSITNEELKTIFTQFGGDVKEIRETPNKKFhKFIEFYDTRDAERALKQLNKTELKGKKIKI 575
                   7999*******************************9986268**************************86 PP

>> BRAP2  BRCA1-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1      0.24   4.3e+02      27      70 ..     525     565 ..     500     570 .. 0.72
   2 !   13.3   0.3   3.9e-05     0.071       6      85 ..     665     748 ..     662     754 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.24
       BRAP2  27 FvgsvlekvseiriirdgkenrymvLikfkdqesadeFykefng 70 
                  + ++  +v   + ir++ ++++   i+f d ++a++  k++n 
  EFC37548.1 525 IFTQFGGDV---KEIRETPNKKFHKFIEFYDTRDAERALKQLNK 565
                 444444444...4578899999999**********999999886 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 3.9e-05
       BRAP2   6 rstllcilavPsylsladllkFvgsvlekvseiriir...dgkenrymvLikfkdqesadeFykefngkkFssleee.vChvvf 85 
                 + t+l++  +P++ + + ll+ v+  +++  ++  +    ++k n   + i+f d +    F ++fn kk++++++e vC +++
  EFC37548.1 665 KRTTLMVKNIPNKYTQKMLLETVDVEFKTAYDFFYLPidfKNKCNVGYAFINFADPKLIIPFVERFNRKKWEKFNSEkVCDITY 748
                 56889999***************977777777777763123334455679***********************997637**998 PP

>> Nup35_RRM_2  Nup53/35/40-type RNA recognition motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0    0.0004      0.71      18      52 ..     437     472 ..     431     472 .. 0.91
   2 ?    2.3   0.0     0.095   1.7e+02      39      53 .]     546     560 ..     526     560 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0004
  Nup35_RRM_2  18 lehFasfGeIvkhyvp.kevsvmyvkfesekdaekA 52 
                  +  F+sfG+I ++y + k + ++ +++ + + a++A
   EFC37548.1 437 RILFESFGPIRQMYTScKHRGFVMITYYDIRHAKQA 472
                  5569************999**************998 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.095
  Nup35_RRM_2  39 myvkfesekdaekAL 53 
                   +++f + +dae+AL
   EFC37548.1 546 KFIEFYDTRDAERAL 560
                  589***********8 PP

>> Smg4_UPF3  Smg-4/UPF3 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       1.2   2.2e+03     117     133 ..     542     558 ..     507     576 .. 0.62
   2 ?   13.3   0.3   3.5e-05     0.062       3      95 ..     666     751 ..     664     763 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.2
   Smg4_UPF3 117 peylaFleslekeeeek 133
                 +++ +F+e +++ ++e+
  EFC37548.1 542 KKFHKFIEFYDTRDAER 558
                 45666666666444443 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 3.5e-05
   Smg4_UPF3   3 ktKvviRrLPPnLteeefleavsdkplpetvdykyFvpGklskdslkeskysrayinfkdpedlvqfakkfdghvFvDskgnespaivefApy 95 
                 +t ++++  P + t++ +le+v+  +++ t  ++ + p +    ++k      a inf dp+ ++ f ++f+  +++  + +e ++ + +A  
  EFC37548.1 666 RTTLMVKNIPNKYTQKMLLETVD-VEFK-TAYDFFYLPID---FKNK-CNVGYAFINFADPKLIIPFVERFNRKKWEKFN-SEKVCDITYARI 751
                 5668999****************.5777.66667788999...4444.4569************************8755.666666666655 PP

>> Limkain-b1  Limkain b1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   9.1e-05      0.16      22      76 ..     519     578 ..     506     586 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 9.1e-05
  Limkain-b1  22 knrLrrLsdncGGkvlsisgksa.....vlrfanqeaaeralkrleneDvfGnritvsek 76 
                 ++ L+ ++   GG v +i ++        + f +   aeralk+l+  +  G++i +  +
  EFC37548.1 519 NEELKTIFTQFGGDVKEIRETPNkkfhkFIEFYDTRDAERALKQLNKTELKGKKIKIEYS 578
                 45699999999*****9998753222227999************************9865 PP

>> PHM7_cyt  Cytosolic domain of 10TM putative phosphate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   3.0    0.0059        11       1     140 [.     419     561 ..     419     578 .. 0.54
   2 ?    2.8   0.1     0.068   1.2e+02       3      72 ..     507     574 ..     505     599 .. 0.66
   3 ?    4.1   0.0     0.028        50       2      26 ..     667     694 ..     666     701 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0059
    PHM7_cyt   1 srTvlvtgiPkelrseeklkeffeelypgkv....ves...vqiv.rdvkkldklveerekavrkleaalskykkngkklpkkrpthklgflglkligk 91 
                 srT++v++i + + ++ +l+ +fe++ p  +    +++   v+i+ +d+++ ++  ++ +  + k+ ++   y   +++ p k++ ++  +  ++ + +
  EFC37548.1 419 SRTLFVRNISSVVDDQ-ELRILFESFGPIRQmytsCKHrgfVMITyYDIRHAKQAKKNLQSKLIKKRKIDIHYSIPKENPPEKEQLNQETLVVFN-LDP 515
                 79***********955.59****988766653222222455333336777777666665544444444444443333333333333333322222.344 PP

    PHM7_cyt  92 kvdaidyyrekleeldeeieeerekvkkkplgaaFvtfesersaaavak 140
                  +   + +++   +    ++e re+ +kk+    F++f ++r+a+ ++k
  EFC37548.1 516 SITN-EELKTIFTQFGGDVKEIRETPNKKF--HKFIEFYDTRDAERALK 561
                 4433.6666666666677777776543333..35777777777777753 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.068
    PHM7_cyt   3 TvlvtgiPkelrseeklkeffeely.pgkvvesvqivrdvkkldklveerekavrkleaalskykkngkkl 72 
                 T+ v ++ ++ ++e +lk++f+++    k++++ + ++++ k+ ++++ r+ a+r+l++  +  +k +k++
  EFC37548.1 507 TLVVFNLDPSITNE-ELKTIFTQFGgDVKEIRE-TPNKKFHKFIEFYDTRD-AERALKQLNKTELKGKKIK 574
                 77777888888855.599999987514444544.88888888888888765.4666655554444444433 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.028
    PHM7_cyt   2 rTvlvtgiPkelrse...eklkeffeel 26 
                  T++v++iP++++++   e+++  f+ +
  EFC37548.1 667 TTLMVKNIPNKYTQKmllETVDVEFKTA 694
                 59***********987777777666655 PP

>> DbpA  DbpA RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.3      0.84   1.5e+03      50      70 ..     468     488 ..     465     489 .. 0.88
   2 ?   11.7   0.1   0.00011       0.2      49      71 ..     554     576 ..     550     577 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.84
                 -HHHHHHHHTT--SSS----E CS
        DbpA  50 kaeevlkalkkkkikGrkvrv 70 
                 +a+++ k+l++k ik+rk+ +
  EFC37548.1 468 HAKQAKKNLQSKLIKKRKIDI 488
                 7999999***********987 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00011
                 T-HHHHHHHHTT--SSS----EE CS
        DbpA  49 ekaeevlkalkkkkikGrkvrve 71 
                 ++ae++lk+l+k+++kG+k+++e
  EFC37548.1 554 RDAERALKQLNKTELKGKKIKIE 576
                 689******************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (778 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       687  (0.0383178); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.75u 0.30s 00:00:01.05 Elapsed: 00:00:00.47
# Mc/sec: 4947.07
//
Query:       EFC37549.1  [L=723]
Description: 3-methyl-2-oxobutanoate hydroxymethyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   4.3e-100  334.4   0.1   6.2e-100  333.9   0.1    1.2  1  Pantoate_transf  Ketopantoate hydroxymethyltransferase
    3.2e-29  101.7   1.4    7.2e-29  100.5   1.4    1.6  1  ApbA_C           Ketopantoate reductase PanE/ApbA C terminal
    8.1e-17   61.3   0.2    1.7e-16   60.2   0.2    1.6  1  ApbA             Ketopantoate reductase PanE/ApbA
    0.00014   21.4   0.3    0.00041   19.9   0.3    1.8  1  PEP_mutase       Phosphoenolpyruvate phosphomutase
    0.00071   19.6   0.3      0.002   18.1   0.3    1.8  1  NAD_Gly3P_dh_N   NAD-dependent glycerol-3-phosphate dehydroge
     0.0013   19.1   0.1     0.0066   16.9   0.0    2.2  2  NAD_binding_7    Putative NAD(P)-binding
  ------ inclusion threshold ------
      0.024   14.9   0.1      0.066   13.5   0.1    1.8  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
       0.04   14.2   0.1       0.22   11.8   0.1    2.3  1  TrkA_N           TrkA-N domain
       0.05   14.2   1.2       0.27   11.9   1.2    2.4  1  F420_oxidored    NADP oxidoreductase coenzyme F420-dependent


Domain annotation for each model (and alignments):
>> Pantoate_transf  Ketopantoate hydroxymethyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  333.9   0.1  3.1e-103  6.2e-100       2     258 ..      75     330 ..      74     331 .. 0.98

  Alignments for each domain:
  == domain 1  score: 333.9 bits;  conditional E-value: 3.1e-103
  Pantoate_transf   2 vtvkdlrkmkeegekiamlTaydattAklvdeagvdviLVGDslgmvvlgyestlpvtleemiyhtkaVargakralvvadlPfgsyeaskeqa 95 
                      vt++ ++ +++++ +++mlTa d+ +A++vd++++d+iLVGDsl+m++lg+++t++vt++emi+h+kaV+rg++ +++++d+Pfgsy +++++a
       EFC37549.1  75 VTLQCINYKYQNQIPLTMLTATDFHSASVVDQTNCDMILVGDSLSMTALGQPNTTSVTMDEMIHHAKAVKRGSQYSFLIGDMPFGSY-VTDDAA 167
                      68899999*******************************************************************************.99**** PP

  Pantoate_transf  96 lenAarllkeggadavKleggaevaetvkalveagipVmgHiGltPqsvnalggykvqgk.teeeaeklledakaleeaGafalvlEavpaela 188
                      ++nA+r++ke+++++vKlegg++va+ +k +v+agi V++HiGltPqs n+lgg++v g  + +ea +l +da+a++eaGa ++vlE+vp++la
       EFC37549.1 168 VHNAVRFIKEAEMNSVKLEGGERVASKIKSIVDAGIVVIAHIGLTPQSCNQLGGFRVVGSkNCSEAIQLWKDALAVKEAGASLIVLECVPQKLA 261
                      **********************************************************974678999*************************** PP

  Pantoate_transf 189 keiteklsiptIGIGAGaacdGqvlvlhDllgltekfkpkfvkkyaelaesieeavkaYaeevkegsFPa 258
                      + it+++ iptIGIG+G+ c+Gqvlv+hDllg+++kf+pkf+k+y++l+ ++ +a+++Y+++v +g+FP+
       EFC37549.1 262 SLITKHIGIPTIGIGSGK-CSGQVLVYHDLLGMYSKFTPKFCKQYLNLNPIMIDACENYVKDVVNGEFPH 330
                      *****************7.**************************************************7 PP

>> ApbA_C  Ketopantoate reductase PanE/ApbA C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.5   1.4   3.6e-32   7.2e-29       6     125 .]     589     721 ..     587     721 .. 0.89

  Alignments for each domain:
  == domain 1  score: 100.5 bits;  conditional E-value: 3.6e-32
      ApbA_C   6 rweKllinaainpltalldckngellespelralvrallkEalava.............eaegve.lseerleeaveavlektaanrsSMlqDveagrk 90 
                  w Kl+in++inpl+ l+++ ng+ll++ +l++l++ l+kE ++++             ++++ + +++  + e+v++++e t+ nr SMl D+e++++
  EFC37549.1 589 DWMKLIINSTINPLASLYQIENGNLLQNLALQNLMKILIKEQVNILrmipgaidslataQEMKDKsIEQV-VYEKVMKICELTSSNRCSMLVDLENQNE 686
                 5*********************************************777777777663322223323333.9*************************** PP

      ApbA_C  91 tEidyinGavvklAeklgvetPvnellyellkale 125
                 tEi y+nGa+v+lA+k +++ P n++++el+ a++
  EFC37549.1 687 TEIMYLNGAFVELANKFKIDSPSNKMIVELITAKQ 721
                 *******************************9886 PP

>> ApbA  Ketopantoate reductase PanE/ApbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.2   0.2   8.7e-20   1.7e-16       1     115 [.     387     508 ..     387     535 .. 0.79

  Alignments for each domain:
  == domain 1  score: 60.2 bits;  conditional E-value: 8.7e-20
                 EEEES-SHHHHHHHHHHHHHTHCEEEE-SCH.HHHH.HHHHCEEEEETT.CEEEEEECEEECCH..SCCCCS-ESEEEE-SSGGGHHHHHHHHG...GG CS
        ApbA   1 iailGaGaiGsllaakLakagadvtlilrsr.rlea.lkknGlrltseg.geeilrppealsae..ekselepidlvivtvKayqteealeeik...pl 91 
                 ++ilG+G++Gsl+a +L   ++dv l+  ++ +le+ ++      ++++ ++ ++   + +s+e  +++ +++id++i++vK+y t +a++++    p 
  EFC37549.1 387 VLILGSGSVGSLFASSL-SSNCDVKLLSGKKtKLEEnIEISTQVREGNEtKSIRNTIVNIISDEelKNAWNGEIDVLIIAVKSYATNQAIQNMMeglPS 484
                 68***************.55***********999875555555555555555555555555555999************************97511144 PP

                 ECTCEEEEEESSSSCHHHHHTTTS CS
        ApbA  92 ldpntvvlllqNGlgheeelreal 115
                 l +  +++++qNG+g+e+ + + l
  EFC37549.1 485 LSKIKHIITVQNGYGNEQNILTSL 508
                 55557************9987766 PP

>> PEP_mutase  Phosphoenolpyruvate phosphomutase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.3     2e-07   0.00041       8     107 ..      87     188 ..      82     265 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 2e-07
  PEP_mutase   8 geplvlpnawDalsakiveeagfkalatsSlavaaslGvpDgeelpleellaavraiaevvs.lPlivDledG.ygespeevaetvrrliaaGvvgvni 104
                 + pl ++ a D  sa++v ++ ++ + ++     ++lG+p +  ++++e++++++a+ +  +   li D+  G y  + + v ++vr + +a +  v +
  EFC37549.1  87 QIPLTMLTATDFHSASVVDQTNCDMILVGDSLSMTALGQPNTTSVTMDEMIHHAKAVKRGSQySFLIGDMPFGsYVTDDAAVHNAVRFIKEAEMNSVKL 185
                 46999************************99999***********************99887366899**98768888999***********9999999 PP

  PEP_mutase 105 EDk 107
                 E  
  EFC37549.1 186 EGG 188
                 977 PP

>> NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.3     1e-06     0.002       1     106 [.     386     498 ..     386     527 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1e-06
                     -EEEE--SHHHHHHHHHHHTTT--EEEE-S-H.HHHHHHHHHSSBTTTBTT-...---TTEEEES-HHHHHTT.--EEEE---HHHHHHHHHHHC CS
  NAD_Gly3P_dh_N   1 kiavlGaGswGtalAkvlaenghevrlwvree.elieeineehenvkyLpgi...klpenlvattdlaealkg.adiivlvvPsqalrevlkklk 90 
                     k+ +lG+Gs G+ +A +l++n+ +v+l + ++ +l e+i+ + +  +  +     +   n+   ++l++a +g  d+++++v s a+++ ++++ 
      EFC37549.1 386 KVLILGSGSVGSLFASSLSSNC-DVKLLSGKKtKLEENIEISTQVREGNETKsirNTIVNIISDEELKNAWNGeIDVLIIAVKSYATNQAIQNMM 479
                     689******************9.7888777775444444433333333233300134457889999****996369****************998 PP

                     CC-...-TT-EEEE---SE CS
  NAD_Gly3P_dh_N  91 gll...kkkailvsliKGi 106
                     + l   +k + ++ +  G 
      EFC37549.1 480 EGLpslSKIKHIITVQNGY 498
                     8774545566666666666 PP

>> NAD_binding_7  Putative NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       2.9   5.9e+03      14      37 ..     187     207 ..     181     263 .. 0.67
   2 !   16.9   0.0   3.3e-06    0.0066       9      82 ..     386     479 ..     382     486 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.9
  NAD_binding_7  14 GgGevAarkvrklleagakvtvva 37 
                    Gg +v a+k++++++ag  ++v+a
     EFC37549.1 187 GGERV-ASKIKSIVDAG--IVVIA 207
                    44444.46888888885..44433 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 3.3e-06
  NAD_binding_7   9 kvlvvGgGevAarkvrklleagakvtvvapevkeele....................elvk.laeeel.ekdlegadlviaatddrelneriaeaa 82 
                    kvl+ G G+v+   +++l ++ ++v++++ +   +le                     +v+ +++eel +++  ++d++i+a++  + n++i +++
     EFC37549.1 386 KVLILGSGSVGSLFASSLSSN-CDVKLLSGKK-TKLEenieistqvregnetksirnTIVNiISDEELkNAWNGEIDVLIIAVKSYATNQAIQNMM 479
                    8***********999999988.*********5.44442444555555554443333222222234446347788899************9998876 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   3.3e-05     0.066       1      83 [.     387     472 ..     387     480 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.3e-05
                      EEEE--SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHH.......TTTCEEEEE--TTTHHHHHHHHHTTS.SEEEE-SSGGGHH CS
  Sacchrp_dh_NADP   1 vliiGaGsvGqavaellarhfdvdaeitvadrskeklealaaka.......lgvrfeaialdaenyeavLaallkeg.dlvvnlsppissl 83 
                      vli+G+GsvG+ +a  l+ + dv  +  + + +k+kle+ ++           +++ ++ +++  +e+ L+ + ++  d+++ ++ ++ ++
       EFC37549.1 387 VLILGSGSVGSLFASSLSSNCDV--K--LLSGKKTKLEENIEIStqvregnETKSIRNTIVNIISDEE-LKNAWNGEiDVLIIAVKSYATN 472
                      89*******************99..3..4444444444444333457777677777777888888888.7777777678877666666555 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   0.00011      0.22       1      87 [.     387     483 ..     387     508 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00011
                 EEEES-SHHHHHHHHHHHHTT.......EEEEEEESSHHHHHHHHHTT....SEEEES-TTSHHHHHHTTGGGESEEEE-SSSHHHHHHHHHHHHHHT CS
      TrkA_N   1 iiiiGlGrvGrslaeeLsegg.......kdvvvidkdeerveelreeg....levvvgdatdeevLeeagiekadaviaatgddeanilavllakeln 87 
                 ++i+G G vG+  a  Ls+++       k  +  + + e   ++re +    ++  + +  ++e L++a   ++d++i+a++++++n ++  ++  l 
  EFC37549.1 387 VLILGSGSVGSLFASSLSSNCdvkllsgK-KTKLEENIEISTQVREGNetksIRNTIVNIISDEELKNAWNGEIDVLIIAVKSYATNQAIQNMMEGLP 483
                 68*****************9955555542.3444444444333333323223556667777889999999999**********999999877776544 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   1.2   0.00013      0.27       2      97 .]     387     497 ..     386     497 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00013
                    EEEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHHHHHC............-EEECE.CHHHHHH.H-SEEEE-S-HHHHHHHHHHC.. CS
  F420_oxidored   2 igiiGaGnmgealasgllaagaqpheivvansrnpekaeelaeelg............vkvtav.dneeaae.eadvvvlavkpedveevlsel.. 81 
                    + i+G+G++g+ +as l+++   + +++ + + + e+  e+  ++             v++++  + + a + e dv+++avk +++ ++++++  
     EFC37549.1 387 VLILGSGSVGSLFASSLSSNC--DVKLLSGKKTKLEENIEISTQVRegnetksirntiVNIISDeELKNAWNgEIDVLIIAVKSYATNQAIQNMme 480
                    6799**********9998774..2233323333333333444444466777777777666666404556666899************999999966 PP

                    .GHHHHTTSEEEEESSS CS
  F420_oxidored  82 .akdalkgklvisvlag 97 
                      ++++k k +i+v +g
     EFC37549.1 481 gLPSLSKIKHIITVQNG 497
                    66788888888888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (723 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.73u 0.35s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 4003.86
//
Query:       EFC37550.1  [L=691]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (691 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.27s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 4182.45
//
Query:       EFC37551.1  [L=373]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (373 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1105  (0.061632); expected 358.6 (0.02)
Passed bias filter:                      642  (0.0358079); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.43
# Mc/sec: 2587.63
//
Query:       EFC37552.1  [L=550]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.015   15.1   0.1      0.029   14.2   0.1    1.4  1  Pox_E10   E10-like protein conserved region


Domain annotation for each model (and alignments):
>> Pox_E10  E10-like protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.1   1.6e-06     0.029      13      45 ..     456     488 ..     449     490 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.6e-06
     Pox_E10  13 vetlPCaeCrahAkeaiqknnvmSskdlNyiyf 45 
                 v++ PC++C+ + +++i  n ++S     y y+
  EFC37552.1 456 VDNTPCVACQLDCLQDIRGNAIFSACATRYFYY 488
                 7899**********************9999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (550 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       763  (0.0425568); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.86u 0.36s 00:00:01.22 Elapsed: 00:00:00.55
# Mc/sec: 2998.91
//
Query:       EFC37553.1  [L=330]
Description: arginase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    9.6e-55  186.0   0.0    1.4e-54  185.5   0.0    1.3  1  Arginase    Arginase family
  ------ inclusion threshold ------
      0.022   15.0   0.5        2.4    8.3   0.1    2.5  3  UPF0489     UPF0489 domain
      0.025   14.8   0.0      0.052   13.8   0.0    1.4  1  Ca_chan_IQ  Voltage gated calcium channel IQ domain


Domain annotation for each model (and alignments):
>> Arginase  Arginase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  185.5   0.0   2.4e-58   1.4e-54       9     275 ..      18     323 ..      10     327 .. 0.81

  Alignments for each domain:
  == domain 1  score: 185.5 bits;  conditional E-value: 2.4e-58
                 E--TTTSSSGGGGGHHHHHHHHHHTSB.T.HCHEETTTTESCCSEEEEEEEEE--............SSCHHHH...HHHHHHHHHHHHHT....TCEE CS
    Arginase   9 PfdaagsgrpGarfGPraireasarle.e.aleynlelgvleelkivdlgdvavt............pvdneev...leqieeavaeilka....gklp 86 
                  + + g+ r+G++ G   +++    l+    +++n +++  ++ +  d+ + + t            + ++++v   ++qi+e++++i++     + ++
  EFC37553.1  18 WCGL-GQRREGVELGAYHLLQTQ-LLNhLpVIKINEKRD--SNSNSPDYSKSPSTlvdkeaddmeicL-NQRRVgsfNQQIAETINTIFQVqsnkKPFI 111
                 4555.899999999999999994.444334555555555..333333333333333334444444432.444456668888888888887455558999 PP

                 EEEESSGGGHHHHHHHHHHHHSTTEEEEEESSS----SSCTTTBSSSTTSHHHH..................HHHH..TSECGCEEEEEEE-STCSHHH CS
    Arginase  87 ivlGGDHsialgilralaekygkplgvihfDAHaDlrtpetegsgnshGtpfrr..................aaee..gllkpkklvqiGirsvdneey 165
                 + +GGDHs+a+g++ a+  +y+ +l+v+++DAHaD++tp+++ s+n hG+p+++                  +++e  +ll +++l+++G+r+vd+ e 
  EFC37553.1 112 VNIGGDHSVAIGSIYAMLMEYP-DLRVLWVDAHADINTPKDSMSKNMHGMPLAFlcgqsilgeernshigfeWMNEeiNLLVSSRLAYLGLRDVDSFEQ 209
                 ********************98.6************************************************54443578999**************** PP

                 HHHHHTTSEEEEHHHHHHHHHHHHHHHHHHHH..TCTTSEEEEEEEGGGBBTTTSTSSSS-BSS-B-HHHHHHHHHHHHCHSEEEEEEEE-B-GGGSST CS
    Arginase 166 elakelgirvitmreidelglkavveeilerv..gaeedpvylSfDiDvlDpavaPGtGtpepgGltlrellallrelaeklnlvgaDvvEvnPaldte 262
                 e++k+ +i+++t+ ei++l++++ +ee  +++  +++e p++lSfD+D++Dp++ P+tGt + +G++ ++ l+++r++++  ++vg+D+vEvnP+  +e
  EFC37553.1 210 EILKKFKIQHFTASEIHQLEIEYCLEECFSHLnlNQSEFPLFLSFDVDGIDPEFTPSTGTAVENGISHQDGLKICRKCQKYSKFVGMDLVEVNPSIGNE 308
                 ********************************4443555***************************************999***************997 PP

                 T..THHHHHHHHHHH CS
    Arginase 263 a..eqtarlaarlvr 275
                 +  ++t + a++ + 
  EFC37553.1 309 EqvNRTISNAMQYIT 323
                 656666666666555 PP

>> UPF0489  UPF0489 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1     0.004        24     124     176 ..      65     117 ..      36     119 .. 0.60
   2 ?    8.3   0.1   0.00041       2.4       6      45 ..     117     153 ..     116     190 .. 0.80
   3 ?   -2.2   0.0      0.69   4.1e+03     158     176 ..     274     297 ..     195     298 .. 0.59

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.004
     UPF0489 124 sdllyvp.eeeleelkqlelevleveeaslsekqdlilavleksksfildiDlD 176
                 s   +v+ e    e++  + +v  ++ +++ e+ ++i++v++++k+fi +i+ D
  EFC37553.1  65 SPSTLVDkEADDMEICLNQRRVGSFN-QQIAETINTIFQVQSNKKPFIVNIGGD 117
                 33334441233334444444555554.3444445558**************876 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00041
     UPF0489   6 sHheaLeaiyraigskklpsdlslvHlDaHpDllipkkms 45 
                 +H  a+  iy ++ +    +dl ++ +DaH+D+  pk+  
  EFC37553.1 117 DHSVAIGSIYAMLMEY---PDLRVLWVDAHADINTPKDSM 153
                 6888888888888887...7**************998433 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.69
     UPF0489 158 l.....ilavleksksfildiDlD 176
                       +l++++k++++   +++D
  EFC37553.1 274 GishqdGLKICRKCQKYSKFVGMD 297
                 033333457777777776666665 PP

>> Ca_chan_IQ  Voltage gated calcium channel IQ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   8.7e-06     0.052      21      68 ..      85     130 ..      74     134 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 8.7e-06
  Ca_chan_IQ  21 eldqadeelrkeikkiwpslskklldllvppekekdelTVGkiYAall 68 
                 ++   ++++ ++i++i++ +s+k    +v   + ++++ +G iYA l+
  EFC37553.1  85 RVGSFNQQIAETINTIFQVQSNK-KPFIVNIGG-DHSVAIGSIYAMLM 130
                 55566999***********9999.456666666.***********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       744  (0.041497); expected 358.6 (0.02)
Passed bias filter:                      595  (0.0331865); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2018.12
//
Query:       EFC37554.1  [L=397]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0047   17.6  28.1     0.0047   17.6  28.1    3.4  1  GRP             Glycine rich protein family
     0.0048   17.0   1.0     0.0089   16.1   1.0    1.5  1  Neur_chan_memb  Neurotransmitter-gated ion-channel transmembr
  ------ inclusion threshold ------
      0.011   14.6   0.1      0.012   14.4   0.1    1.1  1  SAPS            SIT4 phosphatase-associated protein
      0.032   13.1  16.3      0.039   12.8  16.3    1.1  1  Apt1            Golgi-body localisation protein domain
      0.068   13.3   6.9        0.1   12.7   6.9    1.3  1  DDHD            DDHD domain
      0.076   13.0  20.2       0.14   12.1  20.2    1.4  1  DUF4614         Domain of unknown function (DUF4614)
       0.15   12.2  15.2       0.24   11.5  15.2    1.4  1  Transformer     Fruit fly transformer protein
       0.47    9.6   7.1       0.52    9.5   5.9    1.7  2  Zip             ZIP Zinc transporter
       0.66    8.7  17.5       0.88    8.3  17.5    1.1  1  NPR3            Nitrogen Permease regulator of amino acid tra
        1.8    9.1  18.0        2.4    8.7  18.0    1.1  1  SOBP            Sine oculis-binding protein
        2.8    6.6  14.5        4.7    5.9  14.5    1.3  1  Presenilin      Presenilin
        5.2    5.6  13.9        7.2    5.2  13.9    1.2  1  Ndc1_Nup        Nucleoporin protein Ndc1-Nup
          9    6.3   9.0         14    5.7   9.0    1.3  1  RP-C_C          Replication protein C C-terminal region
        9.1    3.3  15.8         11    3.0  15.8    1.0  1  GREB1           Gene regulated by oestrogen in breast cancer


Domain annotation for each model (and alignments):
>> GRP  Glycine rich protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6  28.1   3.7e-06    0.0047       1      95 []       1     115 [.       1     119 [. 0.55

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 3.7e-06
         GRP   1 MaskalilLgl..llaavlLis.sevaaael......skeeksekeeevkdekyggggkh..................ggGgygggggggngGGGykgg 72 
                 M s+ ++ L+l   l+ v+L   s v++ ++      +++ ks  + +v   +                         g+Gg +gggggg gGGG+ g+
  EFC37554.1   1 MSSRCFVCLFLitTLVLVFLLGnSIVVEGTAsqcrgpDNTAKSSAKRGVTTLS------DdleeeelleetlsdaftlGKGGGSGGGGGGRGGGGGGGR 93 
                 77787654444114666655541444444443445665555555555555554......13444568999999*****666666666666566665555 PP

         GRP  73 gGgygggggggeggyGgGygggg 95 
                 gG   gg ggg+g++G+G+gg g
  EFC37554.1  94 GG-SSGGRGGGGGRGGSGRGGSG 115
                 55.55544555555566666543 PP

>> Neur_chan_memb  Neurotransmitter-gated ion-channel transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   1.0     7e-06    0.0089     122     200 ..      75     231 ..       5     249 .. 0.44

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 7e-06
                     ....................................................................................----------- CS
  Neur_chan_memb 122 l...................................................................................ssgasseaeel 133
                                                                                                         +sg+ss++++ 
      EFC37554.1  75 GggsggggggrgggggggrggssggrgggggrggsgrggsgsrggsagrggagrgggkgsgrggagkgsgrgagkgagksgksgKSGKSSASKSK 169
                     15555555555555555555555555555555555555555555555555555555555555555555555555555544433322222222222 PP

                     ---------------------------SS---TTGGG--.....-----TTTTTHHHHHHHHHHHHH CS
  Neur_chan_memb 134 ilskskseskkaklseeqgsekastckckckegeeaspstqlskeelspelkkavegvkyiadhlra 200
                     ++++s     ++k+++++ s+++s++k ++k++++++++++ +++++s++ +k+ ++vk   ++++ 
      EFC37554.1 170 SSKSS-----ASKSKSKSASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSKVKSKVKNVKP 231
                     22222.....222222222222222222222222222222222233333333333333333333333 PP

>> SAPS  SIT4 phosphatase-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.1   9.6e-06     0.012     273     337 ..     163     226 ..      32     246 .. 0.52

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 9.6e-06
        SAPS 273 deaskeesaesedltdkdedvsleesksakdenkesdesesdtaeesseededdasseesalaee 337
                 ++ask++s++s+  ++k ++ s+++sks++  +k++++s+s+++++s+++++ + +++++++++ 
  EFC37554.1 163 SSASKSKSSKSSASKSKSKSASKSKSKSKST-SKSKSKSKSKSKSKSKSKSKAKSKTKSKVKSKV 226
                 2222222222222222222222222222222.222222233333333333332333333332222 PP

>> Apt1  Golgi-body localisation protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8  16.3     3e-05     0.039     324     394 ..     158     223 ..     136     302 .. 0.54

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3e-05
        Apt1 324 sessssssssssssassssssssrssslelrlkptsstssssssessssssskkrsseesslessaservk 394
                  +s +ss s+s+ss+ss+s+s+s+s s++++     +++s+s+s+s+s+s sk++s+++s+++s+++++vk
  EFC37554.1 158 GKSGKSSASKSKSSKSSASKSKSKSASKSKS-----KSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSKVK 223
                 2221111122222222222222222222211.....11222222222222222222222333333333332 PP

>> DDHD  DDHD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   6.9   8.2e-05       0.1     119     170 ..     171     230 ..     139     309 .. 0.42

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 8.2e-05
        DDHD 119 slelae.eesaslaessksherasesskasqeskaaesstasssaksskaee.......k 170
                 s++ a+ ++s+s+++s+++++++s+s+++s+++++++s+++s++++++k++        k
  EFC37554.1 171 SKSSASkSKSKSASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSKVkskvknvK 230
                 111111011111111111111111111111111111111111111111111122222221 PP

>> DUF4614  Domain of unknown function (DUF4614)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1  20.2   0.00011      0.14      11      73 ..     165     226 ..     153     261 .. 0.39

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00011
     DUF4614  11 ssssesessssssessssrslssssesslssksssstdsksssqssestkkrsktktrttvke 73 
                 +s+s+s++ss  s+s+s+++++s+s+s+ +sks+s+++sks+s+s++ +k +sktk+++  k 
  EFC37554.1 165 ASKSKSSKSSA-SKSKSKSASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSKVKSKV 226
                 22222221111.222222222222222222222222222222222222222222222222222 PP

>> Transformer  Fruit fly transformer protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  15.2   0.00019      0.24      53     116 ..     169     239 ..     155     281 .. 0.44

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00019
  Transformer  53 hrerrtrsrsrsqsaeresrqrrrrsrsrsrrrsds..rskssssterrrrsrsrsr.....ysrtPkiit 116
                  + ++ + s+s+s+sa++++ + +  s+s+s+ +s+s  +sks+s ++ + +s+ +s+      +  Pk++ 
   EFC37554.1 169 KSSKSSASKSKSKSASKSKSKSKSTSKSKSKSKSKSksKSKSKSKAKSKTKSKVKSKvknvkPAVKPKVVV 239
                  22233333333333333333333322222222222200222222222233333233220001223344443 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   5.9   0.00041      0.52     111     180 ..     159     227 ..     143     325 .. 0.63
   2 ?   -1.9   0.0       1.2   1.5e+03     226     244 ..     352     370 ..     350     372 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00041
         Zip 111 pkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqaseeedkekla 180
                 ++ +ss s+ +++k+s+s++k+++ ++++++ +++ ++++++++++++k+++++++k++++ ++ k+k++
  EFC37554.1 159 KSGKSSASKSKSSKSSASKSKSKSASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTK-SKVKSKVK 227
                 2222333333333333333333333333332222323333333333333333333333322.34444443 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.2
         Zip 226 peelglgaiLlkaglsrkk 244
                 + e+glg++L k+g+s k+
  EFC37554.1 352 ITEVGLGLCLEKSGCSFKS 370
                 5799***********9886 PP

>> NPR3  Nitrogen Permease regulator of amino acid transport activity 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3  17.5   0.00069      0.88      41     105 ..     157     221 ..     145     267 .. 0.46

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00069
        NPR3  41 dgkwrkskkkkkkskrkrssrskekkskesskksesssksesseekksskeseeseekesneeee 105
                 +gk  ks+ +k+ks++++ s+sk+k+ ++s++ks+s+sks+s++++ks+++s+++++++s+++++
  EFC37554.1 157 SGKSGKSSASKSKSSKSSASKSKSKSASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSK 221
                 22222332222222222222222222222222222222222221111111111111111111111 PP

>> SOBP  Sine oculis-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7  18.0    0.0019       2.4     104     239 ..     163     298 ..     145     318 .. 0.31

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0019
        SOBP 104 ssptssnsskplisvass..skllaeksqepaslveaplepkkqrkkkpglrkpkqvkagsskssetkagllqkq.qkalplsael.eessvpkpflrp 198
                 ss+   ++sk+  s+as+  sk+ ++ +++++s++++++++k+++k+k++++++ + k++s+ +s++  ++++   ++++++++++  +  vp ++ + 
  EFC37554.1 163 SSA---SKSKSSKSSASKskSKSASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSKVKSKV--KNVKPAvKPKVVVKPKVvVKPKVPVKPAVK 256
                 222...1111111111110012222222222222222221111111111111111111111111111..111111223333332220222244333333 PP

        SOBP 199 ppsiqelqsslpnqslpkiapppk.ppstlappsngaerppf 239
                  +   + +ssl++    +   +p+  + t  ++++ a+r++f
  EFC37554.1 257 AAPPASGRSSLSEGARRTVDYNPSrFNITGPTSTSHANRNSF 298
                 333333333333333333222222122222233333344444 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  14.5    0.0037       4.7     251     314 ..     165     221 ..     143     251 .. 0.34

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0037
  Presenilin 251 sskeeeseeesseksaqsseseeeseeesseaessaeesseekeseessesseeeeeeeeeeee 314
                 +sk+++s++++s+++++s+++++++++++s+++s+++++       ++s+s+++++ +++++++
  EFC37554.1 165 ASKSKSSKSSASKSKSKSASKSKSKSKSTSKSKSKSKSK-------SKSKSKSKSKAKSKTKSK 221
                 111111111111111111111111111111111111111.......111111111111111111 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2  13.9    0.0057       7.2     365     436 ..     168     232 ..     148     325 .. 0.47

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0057
    Ndc1_Nup 365 apknkasapvkelprlsksplkkkddeifgnsltaeaspkssssskegvekalsslakspgqs..psptarls.p 436
                  +++k+sa+++++++ sks++k+k          +++++ks+s+sk++ +++ +s aks  +s  +s +++++ +
  EFC37554.1 168 SKSSKSSASKSKSKSASKSKSKSK----------STSKSKSKSKSKSKSKSKSKSKAKSKTKSkvKSKVKNVKpA 232
                 111111111111111111111111..........11111111111111111112222221111111111111111 PP

>> RP-C_C  Replication protein C C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   9.0     0.011        14      46     100 ..     167     247 ..     158     262 .. 0.46

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.011
      RP-C_C  46 alkaenssanesqne.rhiqnsnpdsssesepasekereekeaaaasaeaepsek.........................k 100
                 ++k+++ssa++s+++ + +++s+++s+s+s+++s++++++k +++++a++++++k                         +
  EFC37554.1 167 KSKSSKSSASKSKSKsASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSKvkskvknvkpavkpkvvvkpkvvvkP 247
                 455555555555333023333444444444433333333333333333333333344556666655555555555555554 PP

>> GREB1  Gene regulated by oestrogen in breast cancer
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0  15.8    0.0085        11    1155    1271 ..     164     244 ..     144     312 .. 0.45

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.0085
       GREB1 1155 avesglsskasakselseasaaaasaseeakspkasvtseeeeseeskekekeslsketesqlsleaseqkealdakasskssssssssssassPss 1251
                  ++++++ssk+sa+++ s+++++++s+s++++++k++++s+++++++sk+k k++++++                                     +s
  EFC37554.1  164 SASKSKSSKSSASKSKSKSASKSKSKSKSTSKSKSKSKSKSKSKSKSKSKAKSKTKSK------------------------------------VKS 224 
                  1111122222222211111112222222222222222222222222222222222222....................................333 PP

       GREB1 1252 scslakavkrPpivllskav 1271
                  +++  k++ +P++v+ +k+v
  EFC37554.1  225 KVKNVKPAVKPKVVVKPKVV 244 
                  34444444444444444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2930  (0.163422); expected 358.6 (0.02)
Passed bias filter:                     1009  (0.0562775); expected 358.6 (0.02)
Passed Vit filter:                       357  (0.0199119); expected 17.9 (0.001)
Passed Fwd filter:                        66  (0.00368119); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.96u 0.36s 00:00:01.31 Elapsed: 00:00:00.50
# Mc/sec: 2397.28
//
Query:       EFC37555.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-21   76.4   0.0    2.7e-21   75.3   0.0    1.6  1  Rieske    Rieske [2Fe-2S] domain
    1.5e-11   44.2   0.0    3.1e-11   43.3   0.0    1.5  1  PaO       Pheophorbide a oxygenase


Domain annotation for each model (and alignments):
>> Rieske  Rieske [2Fe-2S] domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.3   0.0     3e-25   2.7e-21       2      83 ..      62     148 ..      61     163 .. 0.93

  Alignments for each domain:
  == domain 1  score: 75.3 bits;  conditional E-value: 3e-25
                 EEEEEEGGGC-..TTCEEEEEETTEEEEEEE-TTS-EEEEESC-TTTT-BCGGSEEE...TT.EEE-TTT--EEETTSBEEE-TTHH CS
      Rieske   2 wvavakesdvp..egdpltvkvggeplvvlrdedgevyAlsdvCtHrgaplsegkid...ekgvleCpcHgwaydadGkvikgPapr 83 
                 w++va ++dv+  + +p+t+k++gepl+++r++dg++ +++d C+Hr a+ls+g+++   +k  leC +Hgw+++++G+++ +P+ +
  EFC37555.1  62 WYPVALSKDVSitDSKPKTIKLFGEPLALYRTSDGNITCVKDLCPHRSAKLSTGQVTefeGKRSLECAYHGWRFEKEGQCVRIPSVS 148
                 9**********97778*************************************9995566899*********************875 PP

>> PaO  Pheophorbide a oxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.3   0.0   3.5e-15   3.1e-11       1      83 [.     309     396 ..     309     399 .. 0.78

  Alignments for each domain:
  == domain 1  score: 43.3 bits;  conditional E-value: 3.5e-15
         PaO   1 FvpPclvkiaieledeeke..krlllvlycvPtapGksrliakfarnfaswlkkl..vP.rwlkhias.nkvldqDlalLheqerklak 83 
                 F+pPc+v+++++    +++  +r+++v++ +Pt++G++++i+kf  +++  l+ l  +P    k  ++ ++++dqDl lL + ++++++
  EFC37555.1 309 FIPPCFVRMDTTDYIANERsgPRMSQVFCLIPTGEGEVKVIFKFYSSLS-ILNFLnkIPfIRNKFAKTvDMIFDQDLELLAGVYENVNN 396
                 9**********9998877789********************99774332.222224466334444444689***********9999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       381  (0.0212505); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.25s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 3034.20
//
Query:       EFC37556.1  [L=266]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   13.3   2.0       0.12   13.2   0.3    2.0  2  YMF19     Plant ATP synthase F0


Domain annotation for each model (and alignments):
>> YMF19  Plant ATP synthase F0
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1      0.33   5.9e+03      26      46 ..      61      81 ..      42     116 .. 0.61
   2 ?   13.2   0.3   6.5e-06      0.12      17      68 ..     141     188 ..     139     214 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.33
       YMF19 26 llknilpkiarilklrkklls 46
                l+ +++ +i+ +l ++k ll+
  EFC37556.1 61 LIDRKIRNIIYSLPFQKYLLE 81
                334555555555555544444 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 6.5e-06
       YMF19  17 lfFitlYivllknilpkiarilklrkkllsslssevsklkkeqknlivskds 68 
                 l+F  lY+ ll++ + +++r +klr+++ s+ s  +  +++e+    ++k s
  EFC37556.1 141 LVFQKLYFALLNRRIKFTNRNMKLREQFRSYTS-YIYAFQEEY---DNFKRS 188
                 78999**********************999855.344444444...333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1077  (0.0600703); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1627.65
//
Query:       EFC37557.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.5e-21   74.7   0.0    6.6e-21   74.5   0.0    1.0  1  Fibrillarin  Fibrillarin
  ------ inclusion threshold ------
      0.026   14.1   0.1      0.091   12.3   0.1    1.9  1  MTS          Methyltransferase small domain


Domain annotation for each model (and alignments):
>> Fibrillarin  Fibrillarin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.5   0.0   7.3e-25   6.6e-21      67     223 ..       2     152 ..       1     154 [. 0.86

  Alignments for each domain:
  == domain 1  score: 74.5 bits;  conditional E-value: 7.3e-25
                  S--TTSEEEEESTTTSHHHHHHHHHHTTTSEEEEEESSHHHHHHHHHHHTTSTTEEEEES-TTSGGGGTTTS-.-EEEEEEESSSTTHHHHHHHHHHH CS
  Fibrillarin  67 pikkgskvLYlGaasGttvsHvsDivgeegvvyavefsprvlrelievakkRknivPileDArkPekYralve.kvDvifaDvaqpdqarilaknakl 163
                   +k+g k+L + +a   t s +sDi+ ++g+vy+v+ s+   + + ++ ++R+n++ i + A++P++Y++ ++ kvD+i ++       + +++nakl
   EFC37557.1   2 SVKPGGKILCIDVAP-ITLSFISDIISTSGKVYCVNSSESDYQIVAKLQSQRNNLIAISGSANNPSEYQSEIPeKVDIIMTN----GTHKAMTENAKL 94 
                  68999*****99985.89***************************************************999769***9875....4567899***** PP

                  HEEEEEEEEEEEEHHHHHSSSSHHHHHHHHHHHHHHTTEEEEEEEE-TTTSTTEEEEEEE CS
  Fibrillarin 164 flkeggyllisikarsidvtkepeevfkeeveklkeeglkvleqvklepyekdhalvvgk 223
                  flkegg + i+++      ++++ e  +e ++ +k + +k+ e ++lep+ +  a++vg+
   EFC37557.1  95 FLKEGGDFYIVLHKPEG-YVQQSVEWTQETITDVK-KYFKPRELLTLEPFSNTDAVFVGT 152
                  ***********997653.34444455555556655.67**************99999986 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1     1e-05     0.091      96     148 ..      74     115 ..      27     132 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1e-05
                 S-EEEEEE---STTTCHCHHHHHHHHHHHHHHHEEEEEEEEEEEETTSCHHHH CS
         MTS  96 kkfdlivsNPPfhagkatelavaeeliaeAkeaLkegGeLliVanrklgyesl 148
                 +k+d+i++N            + +++ ++Ak +LkegG+++iV  +  gy + 
  EFC37557.1  74 EKVDIIMTN-----------GTHKAMTENAKLFLKEGGDFYIVLHKPEGYVQQ 115
                 555555555...........3457899******************99999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       743  (0.0414412); expected 358.6 (0.02)
Passed bias filter:                      577  (0.0321825); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.34s 00:00:00.90 Elapsed: 00:00:00.56
# Mc/sec: 852.21
//
Query:       EFC37558.1  [L=486]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-17   62.5  14.1    2.6e-13   50.2   1.5    4.4  3  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   2.1   3.9e-06     0.069       3      78 ..     101     208 ..      99     237 .. 0.72
   2 !   50.2   1.5   1.5e-17   2.6e-13       4     110 ..     259     373 ..     256     374 .. 0.81
   3 ?    0.5   0.1     0.039   6.9e+02      81     110 ..     383     412 ..     376     413 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.9e-06
                 HHHHHTTTS-EEEEETT.....TEEEEE-HHHHH.HH-HHHHHHHTST...........................TTTTCCCEEEEETTSGHHHHHHHH CS
         BTB   3 elresgelcDvtlvvgd.....gkefkahkavLa.arSpyFkalftsk...........................eieessvseielddvepeafealL 68 
                 +l+++ +++Dv +   +      + ++ah ++L+ ++S+++++lft+                            ++e+  + e+ ++ ++ ++f  +L
  EFC37558.1 101 SLLNNSAFSDVHIIGMNyenneIENLYAHSIILScSCSKVLENLFTKLkylaandkieeipelyseystlfktilYEEKIFKLEL-VESISTQEFITIL 198
                 67888899999999888887877889*******637***********98877777666666555555555555443333333355.4777777777777 PP

                 HHHHHSEEEC CS
         BTB  69 efiYtgelei 78 
                 e  Y+g++ +
  EFC37558.1 199 ELTYCGKTIN 208
                 7777777665 PP

  == domain 2  score: 50.2 bits;  conditional E-value: 1.5e-17
                 HHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST.....TTTTCCCE..........EEE.ETTSGHHHHHHHHHHHHHSEEEC-CGGGHHH CS
         BTB   4 lresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk.....eieessvs..........eie.lddvepeafealLefiYtgeleitseenlee 86 
                 ++ ++e+ Dv++++g +   +a+k++L  +S++Fk++ft++     +      s          e++   + + +  ea+L+ +Y  +  ++ ++++  
  EFC37558.1 259 FFGKKEYADVQFKIG-DNYRYANKCFLFVCSDVFKVMFTDGfiessS------SmteinlfegqELTnSIEDQIKGCEAFLQHVYHRQPVFD-SNSVCT 349
                 567889*********.69***********************654440......333455556653330223356799**********99996.9***** PP

                 HHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  87 lLaaadllqiprlkkaceeflkqs 110
                 +La+a+l+++++l ++ce f+++s
  EFC37558.1 350 ILAIAHLYNMNHLETQCEVFISKS 373
                 ********************9886 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.039
                 GGGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  81 eenleelLaaadllqiprlkkaceeflkqs 110
                 +e+++ l    +l++ ++l k+c ++++++
  EFC37558.1 383 SEEIVTLYLFSKLYNAKQLRKLCLYYMTNN 412
                 67888999999************9999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       917  (0.0511462); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.56
# Mc/sec: 2609.04
//
Query:       EFC37559.1  [L=405]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
        0.3    9.8  10.0       0.42    9.4  10.0    1.1  1  NPR3        Nitrogen Permease regulator of amino acid transpo
       0.81    8.5  10.0          1    8.2  10.0    1.1  1  Apt1        Golgi-body localisation protein domain
        2.3    7.3   4.3        3.9    6.6   4.3    1.4  1  Zip         ZIP Zinc transporter


Domain annotation for each model (and alignments):
>> NPR3  Nitrogen Permease regulator of amino acid transport activity 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4  10.0     7e-05      0.42      48     141 ..     161     251 ..     138     262 .. 0.44

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 7e-05
        NPR3  48 kkkkkkskrkrssrskekkskesskksesssksesseekksskeseeseekesneeeeeeededdeesekeeeekedkkknltmFhlvfvlnPp 141
                 + k++ +++++ss +++ ksk +s+k +s+ ks+ +++ ks+    +s+ k+++++++++++++++++++++ + +   +n++   +  v  Pp
  EFC37559.1 161 RGKSSGKSKGKSSGKSKGKSKGKSSKGKSKGKSKGKSKGKSKG---KSKGKSKSKSKSKSKSKSKAKAKTTKVTRDPLVNNVKKVTVAAVVAPP 251
                 2222333333333333333333333333333322222222221...222222222222222222223333455556666666666666666655 PP

>> Apt1  Golgi-body localisation protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2  10.0   0.00017         1     322     402 ..     164     226 ..     123     303 .. 0.50

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00017
        Apt1 322 eesessssss.ssssssassssssssrssslelrlkpt....sstssssssessssssskkrsseesslessaservkssrasddl 402
                 ++ +s+++ss +s+ +s+ +ss+ +s+ +s+ +    +    + +s+ +s+++s+s+s++k+                   + +  
  EFC37559.1 164 SSGKSKGKSSgKSKGKSKGKSSKGKSKGKSKGK----SkgksKGKSKGKSKSKSKSKSKSKS-------------------KAKAK 226
                 111111111111111111111111111111111....0111111111111111111111111...................11111 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   4.3   0.00065       3.9     109     171 ..     166     228 ..     147     314 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.00065
         Zip 109 ktpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqas 171
                   +k +ss +s+ ++k++ s+ k++++++++++++++++++ ++++++++k+++++++k+++ 
  EFC37559.1 166 GKSKGKSSGKSKGKSKGKSSKGKSKGKSKGKSKGKSKGKSKGKSKSKSKSKSKSKSKAKAKTT 228
                 233444444455555555555555555555555555555555555555555555555554433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1785  (0.0995594); expected 358.6 (0.02)
Passed bias filter:                      702  (0.0391544); expected 358.6 (0.02)
Passed Vit filter:                       154  (0.00858944); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.90u 0.34s 00:00:01.24 Elapsed: 00:00:00.52
# Mc/sec: 2358.25
//
Query:       EFC37560.1  [L=796]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.8e-38  129.9  19.4    2.9e-37  128.3   3.3    2.3  2  ThrE             Putative threonine/serine exporter
    4.6e-11   43.0  25.9    5.2e-09   36.3   8.8    2.3  2  ThrE_2           Threonine/Serine exporter, ThrE
     0.0046   17.0   0.0      0.012   15.6   0.0    1.6  1  Ribosomal_L27    Ribosomal L27 protein
  ------ inclusion threshold ------
      0.086   13.2   3.3       0.16   12.3   1.1    2.3  2  TBCA             Tubulin binding cofactor A
       0.19   11.6   0.6       0.39   10.6   0.6    1.5  1  Rick_17kDa_Anti  Glycine zipper 2TM domain
        6.5    7.1   7.0        1.1    9.5   1.5    2.3  2  DUF2568          Protein of unknown function (DUF2568)


Domain annotation for each model (and alignments):
>> ThrE  Putative threonine/serine exporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.3   3.3   9.9e-41   2.9e-37       3     238 ..     357     620 ..     355     622 .. 0.84
   2 !    6.9   8.3    0.0012       3.5     115     236 ..     658     783 ..     642     786 .. 0.67

  Alignments for each domain:
  == domain 1  score: 128.3 bits;  conditional E-value: 9.9e-41
        ThrE   3 ilrlGeiLlesGaetyrvedtmkriaralgleevevfvtptsiivsv.d.........eeeesitt.vrr.........vrsrgvnleklsevnelsre 81 
                 ++ lG +L ++G +++r+e +++ i++ +g++ +++ +t t++ +s+ d         e+++s++t +               ++nl+kl +++++++e
  EFC37560.1 357 LIDLGFALATFGIPAHRLEYHLTYISKQFGVKPCQIEYTSTGLLFSFsDpidwthfnvENGRSTSTtL-YitidsanlsSAGGSLNLDKLYKLDHIADE 454
                 6889*******************************************779988887765555555423.2578888875588899************** PP

        ThrE  82 iaageisleeaeerLdeIerskprypr.wlvvlaaglaaaafallfggdwidflvaflagllggllrlllakrglnsfvleavaaflaslla....lla 175
                 +a+++i++ +a++r++++ +skp ++  +++++ + l ++a ++++ g++i+++ ++++g+l+gl+  l +++  ++ v+ ++ +++a+++a    +++
  EFC37560.1 455 LAQRKITIPDARTRIRKVIKSKPIFNHsFYQIITHLLNSFAWVVFLDGSIIEMITSCAIGVLVGLFCTLAERYPYFQRVNSVINSVVAGIVAtilkIVF 553
                 ********************99999862678888999999999999*************************9877666666666666666661111555 PP

        ThrE 176 vsl....glglnpdaiiigsillLvPGlpltnavrDllsgdlvsGlaRlveailialaiafGivlal 238
                 +++       l++  ++++++  ++PG+ +t+++++l++++l+sG++Rl+ +++++l ++fG+++a+
  EFC37560.1 554 AQFadpvASPLSVFLVTLCGVFSILPGIQFTTGIAELSTRHLLSGSVRLFSGFIVTLQLGFGVLMAT 620
                 55464332234479***************************************************98 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0012
        ThrE 115 aglaaaafallfggdwidflvaflagllggllrlllakrglnsfvleavaaflasllallavslglglnp.daiiigsillLvPGlpltnavrDllsgd 212
                  ++++  f++ +  +++  + +++++ l +++  +   + l + v  +++a+++++++ l +++   +np   +++++ +lL+P    + +v++ l+  
  EFC37560.1 658 LIIVSNIFTFRVPKKIVTYIFVAIISYLSFFVTTYS-SYYLGTEVGALLGALVCGVTGNLYAHI--TKNPaLLVTVCGTVLLIPAAFGVRGVKEFLTAS 753
                 455666666666666666666666666666666665.555666677788888888888888885..4665499*********************99753 PP

        ThrE 213 ......lvsGlaRlveailialaiafGivl 236
                       l+sG++ +++ + i++++++G +l
  EFC37560.1 754 sgdetsLISGIEFVFNLLSITVSVTIGLLL 783
                 222222777777777777777777777655 PP

>> ThrE_2  Threonine/Serine exporter, ThrE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   9.1   4.2e-05      0.12      22     127 ..     507     620 ..     485     622 .. 0.82
   2 !   36.3   8.8   1.7e-12   5.2e-09      14     129 .]     665     787 ..     653     787 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.2e-05
      ThrE_2  22 allvagllGavgwlvylllme...lgvsialasflaalaigllsellArr...iktPvtvfli..pgllplvPGlaaYktvlslvqgnleeavengiea 112
                 ++  ++++  vg ++ l+  +   + v+ ++ s++a ++ ++l  ++A+    +  P  vfl+  +g++++ PG++ ++ + +l +++l      +++ 
  EFC37560.1 507 MITSCAIGVLVGLFCTLAERYpyfQRVNSVINSVVAGIVATILKIVFAQFadpVASPLSVFLVtlCGVFSILPGIQFTTGIAELSTRHLLSGSVRLFSG 605
                 56667777777777766655566477****************999998873335678888776559********************************* PP

      ThrE_2 113 lliagalavGlvlvs 127
                 +++++ l +G+++++
  EFC37560.1 606 FIVTLQLGFGVLMAT 620
                 **********99986 PP

  == domain 2  score: 36.3 bits;  conditional E-value: 1.7e-12
      ThrE_2  14 vifnvpkrallvagllGavgwlvylllme..lgvsialasflaalaigllsellArriktPvtvflipgllplvPGlaaYktvlslvqgn......lee 104
                 ++f+vpk+ +    +++ +++l+ ++ ++  +  + +++ +l+al+ g+ ++l+A ++k P+ +++++g + l+P ++  + v ++++ +      l  
  EFC37560.1 665 FTFRVPKKIV-TYIFVAIISYLSFFVTTYssYYLGTEVGALLGALVCGVTGNLYAHITKNPALLVTVCGTVLLIPAAFGVRGVKEFLTASsgdetsLIS 762
                 6788888755.556999999999999888656799****************************************777777777777533333444999 PP

      ThrE_2 105 avengiealliagalavGlvlvsli 129
                  +e +++ l+i+++  +Gl+l ++i
  EFC37560.1 763 GIEFVFNLLSITVSVTIGLLLGDFI 787
                 99999*************9998875 PP

>> Ribosomal_L27  Ribosomal L27 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0     4e-06     0.012      15      47 ..     206     238 ..     200     254 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 4e-06
  Ribosomal_L27  15 skgkrlGvKkfggqlvkagnIivrQrgtkfhpG 47 
                    s+ krl  Kk++g++v++ nIi+r +g k    
     EFC37560.1 206 SQNKRLRKKKTSGSFVEKSNIIIRKKGAKTPSA 238
                    899************************997655 PP

>> TBCA  Tubulin binding cofactor A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.1   5.4e-05      0.16      42      74 ..     134     166 ..     125     186 .. 0.90
   2 ?   -0.4   0.0       0.5   1.5e+03      49      69 ..     454     474 ..     441     475 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.4e-05
        TBCA  42 dlkkqeevleetkamipdlkkrlekavekLeel 74 
                 +l +q+e+lee  +mi  + +r+++    ++++
  EFC37560.1 134 QLTQQKELLEERVRMINGMVQRMKETKRTMKQQ 166
                 789**********************99988876 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.5
        TBCA  49 vleetkamipdlkkrlekave 69 
                  l + k  ipd+++r++k ++
  EFC37560.1 454 ELAQRKITIPDARTRIRKVIK 474
                 57778889********99876 PP

>> Rick_17kDa_Anti  Glycine zipper 2TM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.6   0.00013      0.39       1      19 [.     701     719 ..     701     735 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00013
  Rick_17kDa_Anti   1 vGaliGAaaGgvaGaaigg 19 
                      vGal+GA+++gv G++ + 
       EFC37560.1 701 VGALLGALVCGVTGNLYAH 719
                      69*************9854 PP

>> DUF2568  Protein of unknown function (DUF2568)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.4      0.56   1.7e+03      20      47 ..     531     557 ..     503     578 .. 0.58
   2 ?    9.5   1.5   0.00038       1.1      26      90 ..     647     709 ..     641     710 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.56
     DUF2568  20 rlgkgallkivlavllpllaavlWglfa 47 
                 +  ++++ ++v+++++ +l +v  + fa
  EFC37560.1 531 QRVNSVINSVVAGIVATILKIV-FAQFA 557
                 3344444444444444444333.34554 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00038
     DUF2568  26 llkivlavllpllaavlWglfaaPkarvrlpgpvrlllellvfalaalalavaghptlalvfaav 90 
                 + +++la++lpl+++    +f +Pk+   ++ ++  ++  l f+++++  + +g ++ al+ a+v
  EFC37560.1 647 VPEWILALVLPLIIVSNIFTFRVPKKI--VTYIFVAIISYLSFFVTTYSSYYLGTEVGALLGALV 709
                 5689********************876..67899*********************9999887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (796 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1364  (0.0760779); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.84u 0.36s 00:00:01.20 Elapsed: 00:00:00.55
# Mc/sec: 4386.98
//
Query:       EFC37561.1  [L=643]
Description: cleft lip and palate transmembrane family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   9.7e-130  433.4   9.3   1.3e-129  433.0   9.3    1.2  1  CLPTM1    Cleft lip and palate transmembrane protein 1 (CLPTM
    0.00016   21.3   4.7      0.011   15.5   0.5    2.9  2  PQ-loop   PQ loop repeat
  ------ inclusion threshold ------
      0.056   14.4   1.8         13    6.8   0.0    3.5  3  DUF4834   Domain of unknown function (DUF4834)
      0.094   13.0   1.9       0.25   11.6   0.2    2.5  2  Mrx7      MIOREX complex component 7
       0.11   12.8   5.8       0.13   12.6   0.3    2.8  2  2TM       2TM domain
       0.99    9.5  10.6       0.83    9.7   1.6    2.6  2  MtN3_slv  Sugar efflux transporter for intercellular exchange


Domain annotation for each model (and alignments):
>> CLPTM1  Cleft lip and palate transmembrane protein 1 (CLPTM1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  433.0   9.3  4.4e-133  1.3e-129       2     428 ..      34     491 ..      33     492 .. 0.89

  Alignments for each domain:
  == domain 1  score: 433.0 bits;  conditional E-value: 4.4e-133
      CLPTM1   2 slllrvlllyllvslvt..lsgk...............ansppceeepseestpkclapllkegekldlsvyvsesee...fekl........kse..e 70 
                 s++ rvl++++++++++  l+g                +++++++++++ +s +  +ap ++++  ++l++y+s+s++   ++k+        + e  +
  EFC37561.1  34 STISRVLIVFFVMKMISggLFGGggnqanngaassldsKTTTTTTTQSAPSSASIVAAPAFRKSCAMTLQLYLSTSSDrklMRKIydrvnytsS-EpiH 131
                 6899*************8866668999999999998742223333444444467888****************976663444444888877643.2577 PP

      CLPTM1  71 klvlkeknlkygdwee.......sreveltiklpkev.qnNgtlyahvfltksgssldpkdekydkksvvhktkqLtkylpkkkekktknLlkekeeee 161
                 +++l ++++ y+d e+       +++ ++++++   +   N+++++h+fl+++g+sl        +++++h t++++++l+ k++kk++ L+++++++e
  EFC37561.1 132 HELLLQDRVYYDDRESnhktfnlTFNNQTDYPVFYDLlIGNKSVHFHAFLQEEGNSL--------PERILHITHPFSRVLKVKRNKKRNLLFDSSTQNE 222
                 777777777787776666766556666777777766668999***************........99***************66666666667777777 PP

      CLPTM1 162 eeeekeekpvivsywkpnltlslvsdktalskeqlppevaeyikleetg...gqYlPilfvnefwqlkkdlveinetvkelpLtitlsplslwklqlya 257
                 +e+++e ++ ++ ++ p++ ls+v+ ++al+ ++lp+++++ i+l +++   + Y+P+l++n+fw++++++v++n+t k+lpL+++ls ++ wk+q+ +
  EFC37561.1 223 TESSAEVGDLYIPHYLPKVFLSMVDMHDALPLSSLPAHFQSAIHLLPMRgnpKRYYPVLYFNDFWTIRSHFVALNDTLKSLPLELDLSIVNQWKWQFHL 321
                 7779999999************************************999999*********************************************** PP

      CLPTM1 258 smeeslkqqaklgfsekeideiKeilldtnpyLLalTivVsllHsvfefLAFknDisfWrkkksleGlSvrsilanvfsqlvifLYLlDneTSwlilis 356
                 +m+esl++q+++g++e+e deiK++l++tnpyLLa+TivVs+lHsvf+fLAFknDi+f+r++k++eGlS+rsi++n+f+q+ ifLYL+DneTSw+ilis
  EFC37561.1 322 QMDESLRMQKQFGSDEAESDEIKRMLFETNPYLLAITIVVSILHSVFDFLAFKNDIQFYRNQKNMEGLSIRSIFVNCFFQTAIFLYLFDNETSWMILIS 420
                 *************************************************************************************************** PP

      CLPTM1 357 qgiGllielWKitkvvkvrlseegslp.rlkfedkeklsesekkTkeYDeiAfkYLsyvlvPlligyaiYSLl 428
                 +giGllie+WKi kvv+v++++++++p  ++++dk++++es  kTkeYD++A+ YLsyv +Pl++gyaiY+L+
  EFC37561.1 421 NGIGLLIEYWKISKVVDVSIKKTNKFPyFIEITDKSSYVES--KTKEYDNEAITYLSYVFYPLIVGYAIYALY 491
                 ***************************99***********9..****************************97 PP

>> PQ-loop  PQ loop repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.3    0.0024       7.2      27      53 ..     383     409 ..     377     416 .. 0.83
   2 !   15.5   0.5   3.6e-06     0.011       2      31 ..     504     532 ..     499     539 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0024
     PQ-loop  27 rkSteGlSilflllwllGdilsllyli 53 
                  k++eGlSi +++ +++  ++ +lyl+
  EFC37561.1 383 QKNMEGLSIRSIFVNCFFQTAIFLYLF 409
                 4889************99999999988 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 3.6e-06
     PQ-loop   2 seilgyislvlwlvsyiPQiikNykrkSte 31 
                 s+i+g+i++++ ++  +PQ++ Nyk kS+ 
  EFC37561.1 504 STIVGFIYVFG-FLNSVPQVYVNYKLKSVA 532
                 55666666554.45669***********96 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1     0.015        44      12      58 ..      36      82 ..      28     123 .. 0.63
   2 ?   -2.9   0.0       4.7   1.4e+04      17      32 ..     355     370 ..     353     387 .. 0.62
   3 ?    6.8   0.0    0.0043        13      30      65 ..     593     627 ..     501     641 .. 0.65

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.015
     DUF4834 12 iailviglsilsvilrtvfglgsrkkssksaqkqfgnstnsnqqksq 58
                i  ++i++ ++ +i   +fg g ++ ++  a++  ++ t++++++s 
  EFC37561.1 36 ISRVLIVFFVMKMISGGLFGGGGNQANNGAASSLDSKTTTTTTTQSA 82
                55667777777777888899888777664444443333333333332 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 4.7
     DUF4834  17 iglsilsvilrtvfgl 32 
                 ++++i+  il++vf +
  EFC37561.1 355 LAITIVVSILHSVFDF 370
                 5667777777777763 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0043
     DUF4834  30 fglgsrkkssksaqkqfgnstnsnqqksqsrsetke 65 
                 fg g  ++ + ++q++ ++ t++++ +++s++e++ 
  EFC37561.1 593 FGQGGEEQTT-EKQSEITETTTEEKVNEESTEEKQP 627
                 4444433333.2222222222222222222222222 PP

>> Mrx7  MIOREX complex component 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.2   8.3e-05      0.25      16      59 ..     113     156 ..     105     160 .. 0.92
   2 ?   -1.2   0.1      0.85   2.5e+03      23      50 ..     588     615 ..     579     625 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.3e-05
        Mrx7  16 rfVrkihakvngiketeiseekqesellykptrrqklkaFrklF 59 
                 +  rki+ +vn  + ++i++e   ++  y + r+ + k F+  F
  EFC37561.1 113 KLMRKIYDRVNYTSSEPIHHELLLQDRVYYDDRESNHKTFNLTF 156
                 678*****************999*****************9988 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.85
        Mrx7  23 akvngiketeiseekqesellykptrrq 50 
                 ++vn++ +  ++++++++    + t+++
  EFC37561.1 588 KRVNEFGQGGEEQTTEKQSEITETTTEE 615
                 6899998888555444433333444444 PP

>> 2TM  2TM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.3   4.4e-05      0.13      20      56 ..     393     433 ..     381     447 .. 0.77
   2 ?    1.4   1.1      0.14   4.1e+02      13      54 ..     466     517 ..     459     530 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 4.4e-05
         2TM  20 Ylivniflilinl...gsswflwpilf.WgiglllhalkvF 56 
                  ++vn f+++  +   +++ + w+il+  gigll++++k+ 
  EFC37561.1 393 SIFVNCFFQTAIFlylFDNETSWMILIsNGIGLLIEYWKIS 433
                 58899988877556775556667777747*********975 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.14
         2TM  13 FyrhlvvYlivni..flilinl.......gsswflwpi.lfWgiglllhalk 54 
                 + + +++Yl  +   +++++ +       + sw+ +++ ++ g+++++ +l+
  EFC37561.1 466 YDNEAITYLSYVFypLIVGYAIyalynheFRSWYSFVLsTIVGFIYVFGFLN 517
                 5555566665555333333322455566866666554447777777776665 PP

>> MtN3_slv  Sugar efflux transporter for intercellular exchange
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   1.6   0.00028      0.83       6      76 ..     361     432 ..     356     442 .. 0.89
   2 ?    4.0   2.0     0.018        53       2      59 ..     502     559 ..     501     586 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00028
    MtN3_slv   6 lcvvftvavFlsPlsilrkiikkksveelsfllflagllsallWllYGllkkda.liiivNlvgvlleliyl 76 
                 + ++ +v+ Fl+  ++++ ++++k++e+ls+  ++++ +  +  +lY +  +   +i i N++g+l+e  ++
  EFC37561.1 361 VSILHSVFDFLAFKNDIQFYRNQKNMEGLSIRSIFVNCFFQTAIFLYLFDNETSwMILISNGIGLLIEYWKI 432
                 567789999**********************99999999999999999998888889999******998776 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.018
    MtN3_slv   2 llgllcvvftvavFlsPlsilrkiikkksveelsfllflagllsallWllYGllkkda 59 
                 +l+++  ++ v+ Fl  ++++++ +k ksv  ++   ++   l+ ++  l++++++ +
  EFC37561.1 502 VLSTIVGFIYVFGFLNSVPQVYVNYKLKSVAAMPWKSYVYKALNTFVDDLFAFVIQSP 559
                 7899999999*********************************999877777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (643 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1417  (0.079034); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 3719.85
//
Query:       EFC37562.1  [L=191]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-09   37.4   2.4    3.5e-08   34.3   2.4    2.2  2  LPMO_10   Lytic polysaccharide mono-oxygenase, cellulose-degr
  ------ inclusion threshold ------
      0.036   14.2   0.0      0.051   13.7   0.0    1.2  1  Smoa_sbd  Styrene monooxygenase A putative substrate binding 


Domain annotation for each model (and alignments):
>> LPMO_10  Lytic polysaccharide mono-oxygenase, cellulose-degrading
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.21   1.9e+03       1      14 [.      24      37 ..      24      55 .. 0.65
   2 !   34.3   2.4   3.9e-12   3.5e-08      87     194 .]      52     140 ..      31     140 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.21
                -EEEEETTBHHHHH CS
     LPMO_10  1 HGylssPksRqarc 14
                HG   +Pk R+   
  EFC37562.1 24 HGQFINPKPRTFGR 37
                9*********9432 PP

  == domain 2  score: 34.3 bits;  conditional E-value: 3.9e-12
                 S--...EEEESESEEEEEEEESS-S-EEEEEEEEE-TT--TTS-HHGGGEEEBEEEESSCEESCCTCEEEEEEEEETSS--EEEEEEEEEEE.TSTSSS CS
     LPMO_10  87 wakpvqttytegseiefeveltapHktghfefyitkecfdptkpLtwadlepfatvsdpksrapskeatyyrkvklPegrtgehvllqvWqyvtanstq 185
                  +++ +++y+++++++++++++a+H  g +++ i       ++ L  +    +++          + +   ++v++P +r ++ ++lq W ++ an  +
  EFC37562.1  52 AKTKATQNYKANQVVPITWNIQANH-GGVMRISILDYAGGASTILANN----IKS----------AAGDTVVNVTIP-DRYCSNCTLQ-WMWIPAN--E 131
                 3455689******************.8*******98887776667665....222..........22333349****.9*********.***7775..5 PP

                 EEEEEEEEE CS
     LPMO_10 186 eaFynCaDv 194
                   +y+C+D+
  EFC37562.1 132 APYYGCVDI 140
                 69******8 PP

>> Smoa_sbd  Styrene monooxygenase A putative substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   5.7e-06     0.051       7      90 ..      33     116 ..      23     124 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 5.7e-06
    Smoa_sbd   7 elFerdaerspfdrpqRalavayvhgvkpreeesevsvnlvpgvGelfeipaltlsGpceillleavpggpldawkdvktpeeh 90 
                 + F r ++ ++ ++p  ++a +  +   + ++   +++n+ +++G ++ i +l  +G ++++l ++++    d + +v+ p+++
  EFC37562.1  33 RTFGRSDALTQKTSPCGSVAKTKATQNYKANQVVPITWNIQANHGGVMRISILDYAGGASTILANNIKSAAGDTVVNVTIPDRY 116
                 57999999999999999999888877777776777*******************************999999988888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       626  (0.0349155); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.45
# Mc/sec: 1287.36
//
Query:       EFC37563.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.2e-31  108.4   0.0      4e-31  107.6   0.0    1.4  1  Ribosomal_S6e  Ribosomal protein S6e


Domain annotation for each model (and alignments):
>> Ribosomal_S6e  Ribosomal protein S6e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.6   0.0   2.2e-35     4e-31       1     125 []      59     186 ..      59     186 .. 0.97

  Alignments for each domain:
  == domain 1  score: 107.6 bits;  conditional E-value: 2.2e-35
                    -EEEEEETTTTEEEEEE-CHHHCTTCTT-BSSEEEECCTTTSSSTS-EEEEEEEEETTC-BB-TTS-SSSEEEEEEETTSSSS-S...SSSS-EEE CS
  Ribosomal_S6e   1 mklnisdpatgkqklievdekklrtligkrigeevdgdalGeelkgyvlkitggsdkqGfpmkqgvltpgrvrlLlskggvgyrp...rrkGerkr 93 
                    +k+++++ +tg++kl+e+ ++ ++++ g+++g+e+dg+++G+++++y++ki g+sd+ G+++++g+ + g+  +L + g++gyr    +rkGer+r
     EFC37563.1  59 LKFQLACRETGRTKLFEIYGSGAEAFRGRKLGDEIDGSCIGNDFRDYIFKIRGASDHLGTCYTPGLIKYGTSCILRRPGEFGYRGwqaKRKGERRR 154
                    5999*******************************************************************************9866688****** PP

                    EEEE-SB--SSEEEEEEEEEE--SS--TTTSS CS
  Ribosomal_S6e  94 ksvrGcivsadisqlnlvivkkgekdiegltd 125
                      ++Gci+++++++++++i++kg+ +i+gltd
     EFC37563.1 155 IKLKGCILDRNLRAVSAIIIRKGALEIPGLTD 186
                    *******************************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       841  (0.0469072); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1695.67
//
Query:       EFC37564.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       643  (0.0358637); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1264.66
//
Query:       EFC37565.1  [L=377]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.5e-56  187.1   3.1    2.6e-21   75.3   0.0    4.1  3  Mito_carr  Mitochondrial carrier protein
  ------ inclusion threshold ------
      0.086   12.7   0.0       0.78    9.6   0.0    2.2  2  LapA_dom   Lipopolysaccharide assembly protein A domain


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.3   0.0   2.9e-25   2.6e-21       3      94 ..      93     189 ..      91     192 .. 0.92
   2 !   30.0   0.3   4.1e-11   3.7e-07       5      91 ..     194     266 ..     190     271 .. 0.89
   3 !   74.4   0.1   5.6e-25     5e-21       7      94 ..     294     376 ..     290     377 .] 0.96

  Alignments for each domain:
  == domain 1  score: 75.3 bits;  conditional E-value: 2.9e-25
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS.....HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
   Mito_carr   3 lsvlkellaGglagavatlvttPldvvKtrlqtqkksskksksaa.....ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlll 94 
                  +++++++a+ ++ ++++++t+Pldv+K rlqtq++s++  ++++     +++ l +i+k+eG++ l+rGl p+ll+++p+++++ +lye++k  ++
  EFC37565.1  93 APLTQQIIASTFGSCLTAVFTCPLDVIKSRLQTQSNSHQLHTKHHhlpqsTFRGLLSIVKHEGIATLWRGLRPTLLMTIPNNGIYYSLYEKFKVQFK 189
                 678999*******************************887666668999*******************************************98776 PP

  == domain 2  score: 30.0 bits;  conditional E-value: 4.1e-11
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkr 91 
                 ++  l++G++a ++a++vt+P+++ Kt  q++k++                +++     l rG++++llr +p s+l++++ye lk 
  EFC37565.1 194 TFTPLISGCVARIIAVTVTNPIEYFKTASQVSKTKI--------Y------LRDLRWDQLLRGYSATLLRDVPFSSLYWMFYENLKY 266
                 57789**************************99993........3......455568899***********************9995 PP

  == domain 3  score: 74.4 bits;  conditional E-value: 5.6e-25
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
   Mito_carr   7 kellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlll 94 
                  ++l+G+++g++at++t+P+dv+Kt  q+ ++++       ++d+ ++iyk++G++g+ rGl+p++l+vap+ a++ ++ye +k++++
  EFC37565.1 294 ISFLSGAIGGVFATTLTHPFDVIKTNAQNVNSNHVG-----VFDISRSIYKSQGMKGFSRGLMPRCLKVAPSCAIMISTYELIKHMFN 376
                 589*****************************9988.....*********************************************97 PP

>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0     0.078     7e+02      16      56 ..      92     132 ..      80     136 .. 0.78
   2 ?    9.6   0.0   8.7e-05      0.78      19      40 ..     288     309 ..     280     324 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.078
    LapA_dom  16 elpLsllllvafgiGallgwllslwsylrlrrelrrlkkki 56 
                  +pL   ++++ +   l +++++ + +++ r++ ++   ++
  EFC37565.1  92 PAPLTQQIIASTFGSCLTAVFTCPLDVIKSRLQTQSNSHQL 132
                 66777778888888889999999999999999887766665 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 8.7e-05
    LapA_dom  19 LsllllvafgiGallgwllslw 40 
                  s l+l++f+ Ga+ g++++++
  EFC37565.1 288 CSNLILISFLSGAIGGVFATTL 309
                 5789**************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       575  (0.0320709); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2430.23
//
Query:       EFC37566.1  [L=768]
Description: DUF580 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.3e-77  260.4  35.3    2.3e-77  260.4  35.3    3.6  4  Choline_transpo  Plasma-membrane choline transporter
  ------ inclusion threshold ------
      0.011   15.7   0.6      0.011   15.7   0.6    2.8  2  TMEM239          Transmembrane protein 239 family


Domain annotation for each model (and alignments):
>> Choline_transpo  Plasma-membrane choline transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0     0.081   7.3e+02      41      71 ..      73     103 ..      63     167 .. 0.58
   2 ?   -1.1   6.8     0.097   8.7e+02     252     312 ..     302     356 ..     288     362 .. 0.74
   3 !  260.4  35.3   2.6e-81   2.3e-77       4     326 .]     383     700 ..     380     700 .. 0.93
   4 ?   -5.3   6.1       1.8   1.6e+04     176     204 ..     717     745 ..     707     748 .. 0.59

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.081
  Choline_transpo  41 lllvplltllllllvsafwivvavalylass 71 
                      +l+v +++ +++++v+af   + + ly  ++
       EFC37566.1  73 ILFVLYCLGMIAIAVIAFKYGTPSKLYYGTD 103
                      3333333334444444444444444432222 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.097
  Choline_transpo 252 vdfvlflgkllialltgliaylllkatltnpeelnsplvpllvvfiiayliasiflsvyes 312
                       ++ +++ +llia++ g++++l+++     +     +++++l+++++++l +  f++ y+ 
       EFC37566.1 302 RGWKVLFAALLIAMILGFATLLFIRI---FS---GVVVYLTLIICVLSFLGLGAFMTYYGY 356
                      45556788899999999999999982...22...356779999999999999999998875 PP

  == domain 3  score: 260.4 bits;  conditional E-value: 2.6e-81
  Choline_transpo   4 livavllllllivlrkrirlaiallkvaskaiksnpslllvplltllllllvsafwivvavalylassgestdkvnsgsesglaavefessskv 97 
                      +++++l++++  +++ rir ai +++++sk i+++p++l++p+++ +++ l++a+w vv+  ++l+ssg++        ++g  av++++++++
       EFC37566.1 383 MAIGLLIAIVSAIFIMRIRRAIGIIQESSKSIMYMPQVLIMPIIFAIIIGLFAAYWCVVS--IFLYSSGDTH------ISGG--AVKYTMTTWT 466
                      6788899999999999********************************************..8888888875......3444..489******* PP

  Choline_transpo  98 kalllyllfgllWtleflralqqvtvagavasWYfskkkdlpskfpvlkslkraltyhlGSialgSlilaivqllrlileylekklkkk..ena 189
                      +a+++y++fg lW+l+f++a     ++ga+asWY+ ++k+     pv ++++r+   hlG+ a+gSli+ai+q+lrli+e ++++l+ +   n 
       EFC37566.1 467 RAIFAYHIFGGLWILAFIQAAEFLSLSGAIASWYWRREKRFVLGMPVVRAFVRTAVFHLGTAAFGSLIVAIIQMLRLIFEKIQRELETAskGNR 560
                      ************************************4444445569***************************************9999999** PP

  Choline_transpo 190 vakcllcclkcclwclekflkflnrnayimvaiyGksFcesakdafellkrnglrvavldsvvdfvlflgkllialltgliaylllkatltnpe 283
                      ++k + ++++ +lw++ek++kflnr ay+++a+yG++F++sak+af l+ rn++++ +++s+++ vl+l+kl++++lt+l++y + ++t+  + 
       EFC37566.1 561 IVKGCGWYVRAVLWIIEKIIKFLNRQAYVQCAMYGTGFLTSAKNAFLLMIRNPIQMSITQSLSTAVLVLSKLAVSALTCLFTYGIAAKTTFLNT 654
                      **********************************************************************************977776544444 PP

  Choline_transpo 284 ...elnsplvpllvvfiiayliasiflsvyesavdtifvcfaeDpe 326
                         e+++p+++++++fii++ +as+f+ +++ a+dt+++cf+++ e
       EFC37566.1 655 dqkEISNPIFLAAIAFIIGFAVASLFCVIIQCAIDTVLQCFLIEME 700
                      6779**************************************9875 PP

  == domain 4  score: -5.3 bits;  conditional E-value: 1.8
  Choline_transpo 176 leylekklkkkenavakcllcclkcclwc 204
                       +++e+++k ++ + + c lcc+  c +c
       EFC37566.1 717 NRFIEENIKIEQLSSCICPLCCCFTCSCC 745
                      33455566666666666777777666666 PP

>> TMEM239  Transmembrane protein 239 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.7   0.6   1.2e-06     0.011      85     150 ..     288     359 ..     273     360 .. 0.82
   2 ?    1.1   0.4     0.037   3.3e+02      60     120 ..     570     638 ..     559     652 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.2e-06
     TMEM239  85 tgshllrslwpvvaavwkhllpallllvlsalpallfaasf......llllstllsllglltsmtrpgdvid 150
                   s +++++w  ++  wk l+ all+ ++  + +llf   f      l l+  +ls+lgl + mt  g +++
  EFC37566.1 288 EASNVVSTFWDDITRGWKVLFAALLIAMILGFATLLFIRIFsgvvvyLTLIICVLSFLGLGAFMTYYGYTQS 359
                 5688999*******************9999999999975432222227888899***********9998876 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.037
     TMEM239  60 qrllwllesilylllalg.lchalfttg.......shllrslwpvvaavwkhllpallllvlsalpall 120
                 + +lw +e i+ +l   + +  a++ tg       + ll    p+  ++ + l  a+l+l   a+ al 
  EFC37566.1 570 RAVLWIIEKIIKFLNRQAyVQCAMYGTGfltsaknAFLLMIRNPIQMSITQSLSTAVLVLSKLAVSALT 638
                 557899999887765433133456655533333335788888999999999999999987666666552 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (768 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1368  (0.076301); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.89u 0.30s 00:00:01.19 Elapsed: 00:00:00.51
# Mc/sec: 4490.36
//
Query:       EFC37567.1  [L=608]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.2e-17   61.0   0.0    1.4e-16   60.4   0.0    1.4  1  UDPGT            UDP-glucoronosyl and UDP-glucosyl transferas
    6.1e-05   23.0   0.0    0.00011   22.2   0.0    1.4  1  Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal dom


Domain annotation for each model (and alignments):
>> UDPGT  UDP-glucoronosyl and UDP-glucosyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.4   0.0   1.6e-20   1.4e-16     276     389 ..     354     478 ..     330     547 .. 0.80

  Alignments for each domain:
  == domain 1  score: 60.4 bits;  conditional E-value: 1.6e-20
       UDPGT 276 GvvvfSlGsmvseipeekanaiAsaLakipq.kvlW.rfdgkkPstLaknt.........llvkWlPqndlLgHPktkAFvtHaGangvyEaisnGvPm 363
                  vv++++G+ v    ++  ++i + ++  p  ++l+ + +++k +  +  +         l+ kW+ q+++L+HP +  Fv+HaGa++++E+i   vP+
  EFC37567.1 354 KVVYIAFGTKVIISLDHTRKMIQAIMKSDPSlNILFvSNSENKDKIFGDSSmdkewskqiLIKKWVKQVEVLRHPVVSIFVSHAGAHSLFESIDATVPL 452
                 5777777777766666655555444444443234441344556666666556666677768899*********************************** PP

       UDPGT 364 vglPlFgdqrdNikrmeakgaavtln 389
                    P+Fgdq  N  r e  g + t++
  EFC37567.1 453 LLFPIFGDQFLNSIRAEDAGIGKTIH 478
                 ************99888887766655 PP

>> Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.0   1.3e-08   0.00011      73     154 ..     430     506 ..     395     520 .. 0.87

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 1.3e-08
                      H-EEEECS-CHHHHHHHHTT--EEEE--TT....S-HHHHHHHHHHHHHHSSEEEE-STTCHHHHHHHHCCS---S---SSC CS
  Glyco_tran_28_C  73 adLvIsRAGagtiaEllalgkplIlvplpeaaenhqdnNakelekagaalvleqkeltpekLeeallelaaeklrlaekska 154
                       ++ +s+AGa +++E+  + +pl+l+p       +q  N    e+ag +  + + e   e+ ++ ++ l++++++  +k++ 
       EFC37567.1 430 VSIFVSHAGAHSLFESIDATVPLLLFPIFG----DQFLNSIRAEDAGIGKTIHDLEN-QEETIKSIRFLLEKSNEISQKMET 506
                      5799************************99....********************999.677778899888888885555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (608 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       848  (0.0472977); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.71u 0.34s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 3318.47
//
Query:       EFC37568.1  [L=199]
Description: hypothetical protein NAEGRDRAFT_81900 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (199 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       568  (0.0316805); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.34s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 1112.16
//
Query:       EFC37569.1  [L=364]
Description: hypothetical protein NAEGRDRAFT_74761 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     2e-101  339.6   0.0   2.7e-100  335.9   0.0    1.9  1  Actin     Actin
  ------ inclusion threshold ------
       0.09   13.2   0.0       0.16   12.4   0.0    1.5  1  FtsA      Cell division protein FtsA


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  335.9   0.0    3e-104  2.7e-100       4     407 .]       5     364 .]       2     364 .] 0.94

  Alignments for each domain:
  == domain 1  score: 335.9 bits;  conditional E-value: 3e-104
       Actin   4 vsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeehpl 97 
                 ++a+V+DnGs+ ++aG++gedaPk v+p+ +++   r         ++ +g       +el  +sp e+  + +wd +e++w+ +++e l+v pee p+
  EFC37569.1   5 TPAIVIDNGSYAIKAGFSGEDAPKEVFPTTIARNPARPLIGsstekEFIIGRF----SSELDNKSPFENRRISNWDYMENIWHFTFYEALRVAPEEAPI 99 
                 689*****************************988875322222224444433....578999************************************ PP

       Actin  98 lltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtp 196
                 +lte  ++p+++rek+++i+fE+f+ p++yla++ vlsafasgk +++vv++G+++t +vp ++G +L +a  + +lgG+++t++l +l++ +      
  EFC37569.1 100 ILTEHLNTPKEEREKITQIMFETFNAPSFYLANDSVLSAFASGKLNAVVVNMGEEETQIVPMFEGNALPYASSTIELGGRHITDYLINLVKLN------ 192
                 ********************************************************************************************7...... PP

       Actin 197 rylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesal 295
                                         ++  ++++e+e+++++Ke+ c+v++d        ++    ++eLPD +++++g+eRf++pE++F+p+l++ e++ 
  EFC37569.1 193 ------------------------GHGVESFAEKEIVRDLKEKKCYVAKDYD------QEMESFNFELPDKTKLDIGKERFQAPELYFHPQLYEIEQT- 260
                 ........................78899******************99987......4566678******************************999. PP

       Actin 296 eeekskllgiselivaainacdvdl.rpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqE 393
                          +s  i+++i+++d+dl r + +++++++G++sl+pg+++Rl++el +l++ + +v++ ap+ erk+s++iG+SiL+sl+tf++l++sk  
  EFC37569.1 261 --------NLSTAIHNSIMKLDIDLhRIHYYSRVLLSGASSLFPGIEDRLHHELFALSPVSANVRVDAPS-ERKISTFIGASILGSLSTFENLAISKDQ 350
                 ........8****************7789*****************************************.**************************** PP

       Actin 394 YeEqGssvverkck 407
                 YeE G+ vv+rkc+
  EFC37569.1 351 YEEVGPCVVHRKCF 364
                 *************6 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.8e-05      0.16       1      85 [.     147     305 ..     147     331 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.8e-05
                 EEEEE-SSSEEEE.EEETTEEEE.EEEES--HHHHHHHHHHHHT--HHHHHHHHHHH--S--EEEEEHHHHH........................... CS
                 xxxxxxxxxxxxx.xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........................... RF
        FtsA   1 alvDiGagktdva.vaedgalvh.lrvigvggngitkdiakalrtaveeAerikikyGsalaekeigrkels........................... 70 
                 ++v++G + t+++ ++e++al + +++i +gg++it+ + + ++   +  e+ +        ekei  ++l+                           
  EFC37569.1 147 VVVNMGEEETQIVpMFEGNALPYaSSTIELGGRHITDYLINLVKLNGHGVESFA--------EKEIV-RDLKekkcyvakdydqemesfnfelpdktkl 236
                 79**********945566666667*************99888888877777777........22222.1222333334444444444455555555555 PP

                 ......................................................GGGGSTTHHHHHHHH CS
                 ......................................................xxxxxxxxxxxxxxx RF
        FtsA  71 ......................................................ggsalpnleelaera 85 
                                                                        +s  p++e+ +++ 
  EFC37569.1 237 digkerfqapelyfhpqlyeieqtnlstaihnsimkldidlhrihyysrvllsgASSLFPGIEDRLHHE 305
                 555555556666666666666666666666666666666666666666666666566666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (364 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       349  (0.0194657); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.56
# Mc/sec: 1954.07
//
Query:       EFC37570.1  [L=1504]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.4e-47  160.4   0.1    9.8e-47  159.5   0.1    1.3  1  Pkinase      Protein kinase domain
    4.3e-45  154.0   0.0    2.2e-40  138.6   0.0    2.7  3  Pkinase_Tyr  Protein tyrosine kinase
      4e-23   80.2   5.3    2.7e-07   30.3   0.2    8.2  8  NHL          NHL repeat
    5.8e-12   45.8  55.9     0.0003   21.1   9.0    4.6  4  EGF_2        EGF-like domain
    0.00019   21.1   1.1        5.6    6.5   0.0    5.2  5  SGL          SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
       0.26   11.2   0.1       0.44   10.4   0.1    1.2  1  APH          Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  159.5   0.1   3.3e-50   9.8e-47       3     260 ..    1205    1499 ..    1204    1501 .. 0.82

  Alignments for each domain:
  == domain 1  score: 159.5 bits;  conditional E-value: 3.3e-50
                  EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS- CS
     Pkinase    3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsl 95  
                  ++++lG+G+ G V+k +  +++ +vAvK+++ ++++ ++ +++lrE +il kl+hpni+ +y++ +  +++y+++e++e g+l+++l+    ++ + 
  EFC37570.1 1205 NIKRLGTGGIGAVFKST--WKNIQVAVKVFDLNNMNISE-EDFLREATILSKLRHPNIISFYGISSGVTKRYIIMECME-GSLESFLSdlqnESLKC 1297
                  5789***********99..9*************999877.59*************************************.55777777775466668 PP

                  -HHHHHHHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTE.EEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH.....TTSCBSHHHHHH CS
     Pkinase   96 seeeakkiakqilegleylHskg...iiHrDlKpeNiLidekge.lKitDFGlakelesssk..ltsfvgtseYlAPEvl.....keneyskkvDvW 181 
                  + +e  +++ qi+ g++ylH+ +   i+HrDlKp+N+L++++    K++DFGl + l++++   lt+ +gt +Y++PEv       e++  k++D++
  EFC37570.1 1298 PIREKLNLLLQICYGISYLHNLQpnyIVHRDLKPANVLLHNNHSiCKLCDFGLGRVLSTHTYssLTNHIGTCYYMSPEVSmpikeIERSDAKAIDIY 1394
                  888999**************877778**************544459***********99987789**************87875333555999**** PP

                  HHHHHHHHHHHSS-.STTTSSHHHHHHHHHHT..HHHHHHHCTSHH...HHHTTS.......................-HHHHHHHHHHT-SSGCCS CS
     Pkinase  182 slGvilyelltgkp.pfsgekgkekvekeldq..lekilkilgetkeklpeasei.......................seeakdllkkllkkdpkkR 252 
                  s  +ily++l++++ p+ +++++   +  +++     ++ +l+ +  + + + +i                         ++++l++k+++  p+kR
  EFC37570.1 1395 SFSIILYQVLFETTdPYTSSNQNYLRKIRMEKpnQYPSQLLLHRSICEDNLRPKIpfddlescrewciefdeeknaeiYWTITQLITKCWNHYPSKR 1491
                  ********9987653888666655444444444333334444444444444444467777788888888888888887999**************** PP

                  TTHHHHHT CS
     Pkinase  253 ltaeellq 260 
                  + +e+++q
  EFC37570.1 1492 PNIEQVIQ 1499
                  *****988 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.61   1.8e+03     167     206 ..      52      95 ..      49     115 .. 0.68
   2 !  138.6   0.0   7.3e-44   2.2e-40       4     232 ..    1206    1432 ..    1204    1449 .. 0.85
   3 !   12.2   0.1   2.7e-05      0.08     226     259 .]    1468    1501 ..    1440    1501 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.61
                  SGGGGS-HHHHHHSEEEHHHHHHH....HHHHHHHHHTTSSGTT CS
  Pkinase_Tyr 167 lpvkWmapEslkekkftsksDvWs....fGvllwEiftlgespy 206
                  lpv+ map +l+++ +   sD  s    f +l+ Eif+ g+  +
   EFC37570.1  52 LPVQLMAPSILHKSFIYFVSDSSSklnkFHTLTGEIFSVGDFGI 95 
                  79999999999999866666654444449999999999998654 PP

  == domain 2  score: 138.6 bits;  conditional E-value: 7.3e-44
                   EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTT CS
  Pkinase_Tyr    4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekek 99  
                    k+lG G  G V++ t+k      +++VavK+++ ++++ ++e++l+ea+i++kl+hpni++++g+ +   + +i++e + +G+L++fL + ++e+
   EFC37570.1 1206 IKRLGTGGIGAVFKSTWK------NIQVAVKVFDLNNMNISEEDFLREATILSKLRHPNIISFYGISSGVTKRYIIMECM-EGSLESFLSDLQNES 1294
                   689***************......9*******************************************99********77.59******9886666 PP

                   SB..HHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETT.EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.....EEH CS
  Pkinase_Tyr  100 lt..lkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenk.vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.....fts 184 
                   l+  ++++l++ lq++ G++yL++ +   +vHrdl   NvLl++n+ ++k++DfGL r + ++++y++ +++   + +m+pE+ +  k       +
   EFC37570.1 1295 LKcpIREKLNLLLQICYGISYLHNLQpnyIVHRDLKPANVLLHNNHsICKLCDFGLGRVL-STHTYSSLTNHIGTCYYMSPEVSMPIKeiersDAK 1389
                   5522789***************99766669*************987699*********99.9999999999***********98776644443455 PP

                   HHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBH CS
  Pkinase_Tyr  185 ksDvWsfGvllwEiftlgespypglkneevleklkegkrlekpekcpe 232 
                   + D++sf+++l+ ++    +py++  n++ l+k+    r+ekp++ p+
   EFC37570.1 1390 AIDIYSFSIILYQVLFETTDPYTSS-NQNYLRKI----RMEKPNQYPS 1432
                   669*******************765.45555555....4444444444 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 2.7e-05
                   BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  226 kpekcpeelyelmkkcweedpeeRptfselvekl 259 
                   k++++  ++++l++kcw++ p++Rp++++++++l
   EFC37570.1 1468 KNAEIYWTITQLITKCWNHYPSKRPNIEQVIQEL 1501
                   5556677899********************9986 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0   0.00035       1.1       9      27 ..     451     470 ..     445     471 .. 0.81
   2 !   30.3   0.2   9.1e-11   2.7e-07       1      27 [.     499     525 ..     499     526 .. 0.94
   3 ?    0.1   0.0      0.34     1e+03       6      26 ..     550     569 ..     545     570 .. 0.77
   4 !    6.2   0.0    0.0038        11      14      28 .]     613     627 ..     601     627 .. 0.79
   5 !   12.9   0.1   2.8e-05     0.085       1      25 [.     653     676 ..     653     677 .. 0.94
   6 !    8.4   0.0   0.00076       2.3       6      26 ..     713     732 ..     710     732 .. 0.82
   7 !    5.6   0.0    0.0062        18      10      27 ..     771     788 ..     768     789 .. 0.87
   8 ?   -2.1   0.0       1.6   4.9e+03       9      24 ..     827     842 ..     823     845 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00035
                 EE.TTTEEEEEECCCTEEEE CS
         NHL   9 vd.snGdiyVaDsenhrvqv 27 
                 ++ +nG+iy aDs nhr+++
  EFC37570.1 451 IFkQNGEIYFADSQNHRIRK 470
                 4559**************97 PP

  == domain 2  score: 30.3 bits;  conditional E-value: 9.1e-11
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P+G++v++nGdiy++D+ nh++++
  EFC37570.1 499 LSNPNGIVVLKNGDIYISDTDNHCIRQ 525
                 689**********************86 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.34
                 EEEEETTTEEEEEECCCTEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvq 26 
                 G++  ++ ++++aD+ ++r++
  EFC37570.1 550 GLSF-NSTHLFIADTLHNRIV 569
                 5555.5779*****9999986 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0038
                 EEEEEECCCTEEEEE CS
         NHL  14 diyVaDsenhrvqvF 28 
                 d+ +aD++nh ++ F
  EFC37570.1 613 DLMIADTNNHKIKRF 627
                 5679********998 PP

  == domain 5  score: 12.9 bits;  conditional E-value: 2.8e-05
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 ++yPh v+v ++  i++aDs+n+r+
  EFC37570.1 653 LSYPHAVVV-DGSAIVIADSYNSRI 676
                 78*******.6*************8 PP

  == domain 6  score: 8.4 bits;  conditional E-value: 0.00076
                 EEEEETTTEEEEEECCCTEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvq 26 
                 G+ + +++ iy++Ds n+rv+
  EFC37570.1 713 GLFI-DSDSIYISDSSNNRVR 732
                 5555.799***********96 PP

  == domain 7  score: 5.6 bits;  conditional E-value: 0.0062
                 ETTTEEEEEECCCTEEEE CS
         NHL  10 dsnGdiyVaDsenhrvqv 27 
                 +s G+i+ aD++nh +++
  EFC37570.1 771 NSKGEIIFADFYNHLIRK 788
                 499************986 PP

  == domain 8  score: -2.1 bits;  conditional E-value: 1.6
                 EETTTEEEEEECCCTE CS
         NHL   9 vdsnGdiyVaDsenhr 24 
                  ++ +d+y +D++n  
  EFC37570.1 827 SLNENDFYFCDTGNRL 842
                 458999999**99955 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   8.0   2.3e-06     0.007       5      32 .]     969     995 ..     965     995 .. 0.90
   2 !   16.0   4.0   3.9e-06     0.012       6      32 .]    1009    1034 ..    1005    1034 .. 0.89
   3 !   10.0  11.0    0.0003      0.89       4      32 .]    1042    1074 ..    1039    1074 .. 0.88
   4 !   21.1   9.0     1e-07    0.0003       4      32 .]    1085    1113 ..    1082    1113 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C  ++ +C+C+++y G+ C
  EFC37570.1 969 SSVCSGNGDCLYPN-KCSCSTNYIGDEC 995
                 678*******9777.************* PP

  == domain 2  score: 16.0 bits;  conditional E-value: 3.9e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  e C+g+G+C ++  +C+C  gy G  C
  EFC37570.1 1009 EVCNGRGQCLSPD-NCKCMEGYVGMVC 1034
                  57********999.8*******99766 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.0003
       EGF_2    4 s..deiCgg..hGtCvnqcGqCdC.dsgyqGktC 32  
                     ++ Cgg  +G+Cv++  qC C + +y+G  C
  EFC37570.1 1042 KptNTSCGGsyNGKCVEKD-QCLCtPKKYSGREC 1074
                  445788**********999.*************9 PP

  == domain 4  score: 21.1 bits;  conditional E-value: 1e-07
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + d+ Cgg+GtC ++   C+C+++y+G++C
  EFC37570.1 1085 NdDSVCGGRGTCLEPDY-CECKNNYHGDQC 1113
                  4599*********9996.************ PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.17   4.9e+02      21      75 ..     120     179 ..     107     193 .. 0.76
   2 !    6.5   0.0    0.0019       5.6      84     160 ..     498     570 ..     429     580 .. 0.55
   3 ?   -0.3   0.0      0.22   6.7e+02      11      41 ..     663     693 ..     655     703 .. 0.79
   4 !    5.0   0.0    0.0052        16     133     216 ..     706     795 ..     699     800 .. 0.86
   5 ?    0.5   0.1      0.13   3.8e+02     142     225 ..     827     917 ..     809     930 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.17
         SGL  21 gqrihrldpatgketvldtpesvGaiaprkdgrlvvasksglall.....dlasgeletl 75 
                   +i+ l+p+ g++tv+ t + v + +   ++ +++a+ s+++ +     + ++++++tl
  EFC37570.1 120 SDKIIMLSPERGNTTVYYTGNIVNMDFVIYEDSFIIANGSSIVKIfnmtlNRTTSQFTTL 179
                 679999***************9999999999*********99877643223333344433 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0019
         SGL  84 pllrfNDgvvdpdGrlwfGtmgdeeakgeevgalyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwa 160
                  l  +N +vv ++G +++ + +++  ++ ++g+l  + +   +   l+ l+ p Gl +++  ++l++aD+l+++i+a
  EFC37570.1 498 YLSNPNGIVVLKNGDIYISDTDNHCIRQIKNGTLSNFVGI--CGSSLSPLKGPYGLSFNS--THLFIADTLHNRIVA 570
                 3455666666666666666666666666666666655544..666666666666666653..556666666666666 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.22
         SGL  11 egaLlwvDilgqrihrldpatgketvldtpe 41 
                 + a++  D +++ri+ ++p tg++ v+ t e
  EFC37570.1 663 GSAIVIADSYNSRIISYSPTTGRTMVIGTGE 693
                 6778888999999999999999998877655 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.0052
         SGL 133 ltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                 +++ N  ++  d++ +Y+ Ds ++++   ++d  +   s+ +v   + +++       ++ G++  ++G+++ A + ++ +++++ +G +
  EFC37570.1 706 IKFFNPKGLFIDSDSIYISDSSNNRVRLLSLDLRSLAFSALTVAGGIGDYGksldavAKVGGAFSNSKGEIIFADFYNHLIRKISIEGIV 795
                 66677777888999***************************99999998887777774477999999****************9999855 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.13
         SGL 142 spdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge....gepDGlavDaeGnvwvAvw...gggkvvrfdpdGklieeiklpak 225
                 s  ++ +Y++D+ +r i +++    ++  +    +ad+ k++     +p ++ v+++  ++ A +    + +v +++ +   i++++++++
  EFC37570.1 827 SLNENDFYFCDTGNRLIRKVSNGYVTTIAGGGNIIADGIKATdaqlTYPLSIQVTKSEDIFFADYfsiTSYTVKKISHKDGTIRTVAMDVS 917
                 5678889999999999999998888887888888888777776777778888888888888888777677788888888556777777755 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.1   0.00015      0.44     163     186 ..    1319    1341 ..    1286    1351 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00015
                  SS-EEEE-SS-SGGGEEEC..TTE CS
         APH  163 elptvllHgDlhpgNllvdpddgr 186 
                   +p  ++H+Dl+p N+l++ +++ 
  EFC37570.1 1319 LQPNYIVHRDLKPANVLLH-NNHS 1341
                  67889**************.5444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1504 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       699  (0.0389871); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.95u 0.35s 00:00:01.29 Elapsed: 00:00:00.54
# Mc/sec: 8439.41
//
Query:       EFC37571.1  [L=608]
Description: hypothetical protein NAEGRDRAFT_59739 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.18   11.8   2.8        9.1    6.3   0.0    3.3  3  Frankia_peptide  Ribosomally synthesized peptide prototyped b


Domain annotation for each model (and alignments):
>> Frankia_peptide  Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.3     0.057     1e+03      34      58 ..      17      40 ..       6      42 .. 0.76
   2 ?    3.1   0.1    0.0052        93      30      50 ..      87     107 ..      84     111 .. 0.89
   3 ?    6.3   0.0   0.00051       9.1      17      45 ..     502     531 ..     496     539 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.057
  Frankia_peptide 34 ltpeElqalekadadsleavalgld 58
                      ++eEl+  + a+a+s+ a ++ +d
       EFC37571.1 17 HDEEELENNN-AAASSSSAADQMVD 40
                     58999*9986.77888877777777 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.0052
  Frankia_peptide  30 agYdltpeElqalekadadsl 50 
                      + Y++++  l++l+ka+++s+
       EFC37571.1  87 EDYEVGEIDLRQLNKAATSSS 107
                      68****************987 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.00051
  Frankia_peptide  17 qrLladpeeav.keagYdltpeElqaleka 45 
                      q+ l +++ a+ + +g +lt+eEl+ + +a
       EFC37571.1 502 QQHLQSSDSAIvRPEGEELTDEELKTIHEA 531
                      555667777777************999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (608 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1862  (0.103854); expected 358.6 (0.02)
Passed bias filter:                      703  (0.0392102); expected 358.6 (0.02)
Passed Vit filter:                       101  (0.00563333); expected 17.9 (0.001)
Passed Fwd filter:                        40  (0.00223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.08u 0.39s 00:00:01.47 Elapsed: 00:00:00.55
# Mc/sec: 3304.17
//
Query:       EFC37572.1  [L=388]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-46  157.6   0.0    8.9e-46  155.5   0.0    1.9  2  2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, 
    1.3e-25   89.6   0.0    2.1e-25   88.9   0.0    1.2  1  2-Hacid_dh    D-isomer specific 2-hydroxyacid dehydrogenase, 


Domain annotation for each model (and alignments):
>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0     0.085   7.6e+02      84      99 ..      89     104 ..      74     109 .. 0.81
   2 !  155.5   0.0     1e-49   8.9e-46       1     178 []     163     354 ..     163     354 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.085
                   SHHHHHHH-SEEEE-S CS
  2-Hacid_dh_C  84 sleellaesDivslhl 99 
                   s  el ++sD+vs+ +
    EFC37572.1  89 STVELAEHSDFVSVFV 104
                   77899********976 PP

  == domain 2  score: 155.5 bits;  conditional E-value: 1e-49
                   HHHHHHHHTTHHHHHHHHHTTCCHTTCCGSBS-GTTSEEEEES.-SHHHHHHHHHHH.HTT-EEEEESSSHHHHHCHHHHTCEEC.SHHHHHHH-SE CS
  2-Hacid_dh_C   1 lalllallrrlaeadeevregewksekallgkelsgktvGiiG.lGrIGqavakrlk.afgmkviaydrskkkeeeeeelgvelv.sleellaesDi 94 
                   +al++al+r++++a +++r+ ++ s + l+g ++s k  Gi+G  G+IG+ vak+l+ +fg++vi+yd ++++e    ++g+e+v +++ ++a+sD+
    EFC37572.1 163 IALIMALNRKIHKAFNRLRDSDF-SLDGLMGFNMSSKVFGIVGgSGKIGKLVAKCLRmGFGARVIVYDSYRDPE--LVNMGIEFVdNIDSIYAHSDV 256
                   689********************.99****************648*************************9965..58899998889********** PP

                   EEE-S--ST.TTTTSBSHHHHHCSTTTEEEEESS-GGGB-HHHHHHHHHTTSCCEEEES--SSS..........SSGTC...HHHHHSTTEEE-SS- CS
  2-Hacid_dh_C  95 vslhlpltp.etrhlinaeelakmkkgailiNtaRGglvdeeaLleaLksgkiagaalDvfeee..........plped...spllelpnviltPHi 177
                   ++lh+pl +  t+hlin+e+++kmk+g+++iNt+RGgl+ +++L+e Lks+ki+  ++Dv+e e          ++ +d   ++ll++pnvi+tPH 
    EFC37572.1 257 ICLHCPLIKgVTEHLINSESISKMKDGVMIINTSRGGLCRTDDLIEGLKSQKIGSLGIDVYEFEqdlffedrrfEIIKDdtfTRLLTFPNVIVTPHQ 353
                   ******76527**********************************************************9999955445233588***********8 PP

                   T CS
  2-Hacid_dh_C 178 a 178
                   a
    EFC37572.1 354 A 354
                   7 PP

>> 2-Hacid_dh  D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.9   0.0   2.3e-29   2.1e-25      21     123 ..      78     375 ..      64     386 .. 0.97

  Alignments for each domain:
  == domain 1  score: 88.9 bits;  conditional E-value: 2.3e-29
                 EEEEESCSSHHHCHHHHTTESEEEE-TTS-BSHHHHHHH...TT--EEEESSSSCTTB-HHHHHHTT-EEEE-TTTTHHHHHHHH.............. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.............. RF
  2-Hacid_dh  21 evevkdellteellekakdadalivrsntkvtaevleal...pkLkviaragvGvDnvDldaakerGilVtnvpgystesvAElt.............. 102
                 ++++ d+ lte ++e a+  d++ v++n+ ++++vl+ l    ++k++a++++G++nvDl+aa+e G++V++vp+ys+ ++A++t              
  EFC37572.1  78 HLKFVDARLTESTVELAEHSDFVSVFVNDCLNRNVLQTLshkYGIKCVALRSAGFNNVDLSAASEFGVKVCRVPEYSPAATADFTialimalnrkihka 176
                 678999**********************************999******************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
  2-Hacid_dh 103 ................................................................................................... 102
                                                                                                                    
  EFC37572.1 177 fnrlrdsdfsldglmgfnmsskvfgivggsgkigklvakclrmgfgarvivydsyrdpelvnmgiefvdnidsiyahsdviclhcplikgvtehlinse 275
                 *************************************************************************************************** PP

                 ...............................................................................T-BHHHHHHHHHHHHHHHHH CS
                 ...............................................................................xxxxxxxxxxxxxxxxxxxx RF
  2-Hacid_dh 103 ...............................................................................aaTeeaqeniaeeaaenlva 122
                                                                                                ++T+ea++nia++++e+l +
  EFC37572.1 276 siskmkdgvmiintsrgglcrtddlieglksqkigslgidvyefeqdlffedrrfeiikddtftrlltfpnvivtphqaFFTQEAISNIAQTTLESLYS 374
                 ***********************************************************************************************9987 PP

                 H CS
                 x RF
  2-Hacid_dh 123 f 123
                 f
  EFC37572.1 375 F 375
                 7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (388 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       517  (0.028836); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 2261.47
//
Query:       EFC37573.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0062   16.3   0.7     0.0093   15.7   0.7    1.2  1  ABA_GPCR  Abscisic acid G-protein coupled receptor


Domain annotation for each model (and alignments):
>> ABA_GPCR  Abscisic acid G-protein coupled receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.7   5.2e-07    0.0093       2      76 ..      72     146 ..      71     148 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 5.2e-07
    ABA_GPCR   2 rsstllgkllkvlgvvfaiYCvyrilktllnllpriilsssssDplavtlaklllrhfdlkl.dlealsrqiSllL 76 
                 ++++ll+ ++kvl+ +f++ +  ril +++  ++++++  + +D ++++  k l ++f++++ +l a++ +iSl++
  EFC37573.1  72 KKPKLLKIIVKVLQGLFTAASNQRILEIFIRSFRSQHFYDRMTDVISTISFKYL-TKFQVQIrELIAVVDKISLAF 146
                 57889999***************************9998799999999988888.9******99*********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1081  (0.0602934); expected 358.6 (0.02)
Passed bias filter:                      625  (0.0348597); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1269.40
//
Query:       EFC37574.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       723  (0.0403257); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.25s 00:00:00.74 Elapsed: 00:00:00.43
# Mc/sec: 1914.87
//
Query:       EFC37575.1  [L=323]
Description: hypothetical protein NAEGRDRAFT_81905 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1725  (0.0962128); expected 358.6 (0.02)
Passed bias filter:                      263  (0.014669); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 1900.86
//
Query:       EFC37576.1  [L=500]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-09   38.5   4.7    2.6e-09   37.4   4.7    1.6  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.4   4.7   1.5e-13   2.6e-09       1      90 [.     369     458 ..     369     487 .. 0.85

  Alignments for each domain:
  == domain 1  score: 37.4 bits;  conditional E-value: 1.5e-13
                 -HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTT CS
         RGS   1 sleslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklf 90 
                 +le+l++d + ++lF+ ++ +efs en  ++++ e++k++++   +++++k ++++y+++ s+ e+n+++  ++el +  e++qp +  +
  EFC37576.1 369 RLEELMKDDTFKELFKMYCAKEFSLENALLYEELENLKEKDDVLVTVETFKHLFETYFQSLSKYEVNLPSPAKKELVSIYENQQPVKLSL 458
                 689*************************************99999*************************************97766444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (500 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1247  (0.0695521); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 3314.78
//
Query:       EFC37577.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1276.34
//
Query:       EFC37578.1  [L=3323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.6e-37  122.5  46.9     0.0011   18.9   0.2   18.2 17  TPR_2            Tetratricopeptide repeat
    1.6e-24   86.2  20.2    0.00041   20.8   0.0   13.2 11  TPR_19           Tetratricopeptide repeat
    2.2e-24   84.2  54.4    9.9e-05   22.0   0.1   17.8 18  TPR_1            Tetratricopeptide repeat
    1.5e-19   70.3   0.4      0.011   16.4   0.6    8.7  7  TPR_16           Tetratricopeptide repeat
    5.3e-16   57.9   6.3        4.3    8.4   0.0   13.3 13  TPR_14           Tetratricopeptide repeat
    2.9e-15   55.7  15.4     0.0017   18.0   0.1    9.2 10  TPR_11           TPR repeat
    6.8e-13   48.6  48.3     0.0018   18.4   0.2   10.1 10  ANAPC3           Anaphase-promoting complex, cyclosome, subun
    1.4e-12   47.0   6.9    5.3e-05   22.7   0.1    4.5  4  Kelch_1          Kelch motif
    8.3e-12   44.3  44.5      0.031   14.5   0.2   15.7 14  TPR_8            Tetratricopeptide repeat
      2e-10   40.7   0.5      2e-06   27.9   0.0    4.0  3  Kelch_3          Galactose oxidase, central domain
    4.2e-10   39.5  10.1    2.9e-05   23.9   2.5    3.5  2  GRAM             GRAM domain
    1.4e-09   38.1  29.8       0.17   12.2   2.3   12.5 13  TPR_12           Tetratricopeptide repeat
    4.4e-09   36.4   0.2       0.64   10.2   0.0    6.7  6  TPR_9            Tetratricopeptide repeat
    7.3e-09   35.6   2.9    0.00056   20.1   0.0    4.4  4  Kelch_6          Kelch motif
    1.2e-07   31.2  12.4      0.079   12.2   0.3    6.4  5  TPR_15           Tetratricopeptide repeat
    3.2e-07   29.9   8.9       0.11   12.6   0.2    9.5 10  TPR_7            Tetratricopeptide repeat
    5.7e-07   29.4   7.3    0.00095   19.1   0.1    4.1  4  Kelch_4          Galactose oxidase, central domain
    1.5e-05   25.0  11.9       0.51   10.4   0.1    6.6  7  DUF627           Protein of unknown function (DUF627)
    0.00027   20.9   0.7        1.4    9.0   0.0    4.4  4  Kelch_5          Kelch motif
    0.00056   20.4  17.3         19    6.1   0.0   11.2  9  TPR_6            Tetratricopeptide repeat
     0.0048   16.3   5.1       0.85    8.9   0.0    3.5  3  TPR_MalT         MalT-like TPR region
      0.008   16.4   0.1      0.008   16.4   0.1    4.6  2  Membr_traf_MHD   Munc13 (mammalian uncoordinated) homology do
  ------ inclusion threshold ------
      0.029   14.8  16.2         43    4.8   0.0    9.2  8  TPR_17           Tetratricopeptide repeat
       0.14   12.6   7.1         20    5.7   0.3    5.7  5  Alkyl_sulf_dimr  Alkyl sulfatase dimerisation
       0.36   10.9  10.6         12    6.1   0.1    4.2  4  Kelch_2          Kelch motif
       0.39   11.1   7.4         14    6.1   0.2    4.9  4  TPR_20           Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.9   0.0    0.0013      0.87       4      31 ..     379     406 ..     376     409 .. 0.89
   2 ?    2.6   0.1      0.27   1.9e+02       4      30 ..     458     484 ..     456     486 .. 0.87
   3 ?    6.0   0.2     0.022        15       4      30 ..     673     699 ..     670     702 .. 0.90
   4 !    8.8   0.0    0.0028       1.9       2      29 ..     705     732 ..     704     735 .. 0.91
   5 !   13.0   0.0   0.00012     0.086       7      34 .]     781     808 ..     775     808 .. 0.90
   6 ?    5.6   0.0      0.03        21       2      34 .]     844     876 ..     843     876 .. 0.95
   7 ?   -0.6   0.1       2.7   1.9e+03       2      30 ..     960     988 ..     959     991 .. 0.87
   8 ?    4.3   0.0     0.076        52      13      30 ..    1112    1129 ..    1101    1133 .. 0.83
   9 !   18.9   0.2   1.6e-06    0.0011       2      32 ..    1146    1176 ..    1145    1178 .. 0.92
  10 !    9.2   0.0    0.0021       1.4       4      33 ..    1182    1211 ..    1179    1212 .. 0.90
  11 !   12.9   0.1   0.00014     0.094       5      34 .]    1235    1264 ..    1231    1264 .. 0.91
  12 !    8.0   0.0     0.005       3.4       2      34 .]    1266    1298 ..    1265    1298 .. 0.95
  13 ?    4.9   0.0     0.049        34       9      34 .]    1307    1332 ..    1306    1332 .. 0.93
  14 !    9.7   0.3    0.0015         1       9      31 ..    1360    1382 ..    1359    1385 .. 0.86
  15 !    8.9   0.1    0.0025       1.7       1      31 [.    1386    1416 ..    1386    1418 .. 0.93
  16 !   12.0   0.1   0.00025      0.17       2      30 ..    1420    1448 ..    1419    1451 .. 0.90
  17 ?    6.3   0.2     0.018        12      16      34 .]    1544    1562 ..    1542    1562 .. 0.94

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0013
       TPR_2   4 lynlGlayyklgdyeeAleafekAleld 31 
                 +  ++++y+kl+ +++A  + e+ l+l 
  EFC37578.1 379 YRTRAECYMKLKMWDKANIDVEEGLKLR 406
                 889**********************996 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.27
       TPR_2   4 lynlGlayyklgdyeeAleafekAlel 30 
                 +  ++++ +k  +++eA+++ ++ l++
  EFC37578.1 458 YKIRAKCRIKERNFNEAINDANRFLKY 484
                 5668999*************9998875 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.022
       TPR_2   4 lynlGlayyklgdyeeAleafekAlel 30 
                   +l++a y + dy++++++ +k+le 
  EFC37578.1 673 IIALADAFYLKTDYKQCVKYAKKVLEM 699
                 5789*********************96 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.0028
       TPR_2   2 ealynlGlayyklgdyeeAleafekAle 29 
                 +a+y +G +y+++ +  +A+e+f + +e
  EFC37578.1 705 KAYYIIGSCYLAKRKVTKAIEFFGQGVE 732
                 79*********************98776 PP

  == domain 5  score: 13.0 bits;  conditional E-value: 0.00012
       TPR_2   7 lGlayyklgdyeeAleafekAleldPnn 34 
                  ++ ++++g+ye+Al   ++++e dP+n
  EFC37578.1 781 YAKQLFQQGNYEDALLTINEVIEKDPTN 808
                 68889*********************98 PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.03
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                 e++ ++G a+  l++y   +  +e+A +  P+n
  EFC37578.1 844 EGYLCQGVALQFLNRYHHSITVLEAAMRMFPEN 876
                 78999**************************97 PP

  == domain 7  score: -0.6 bits;  conditional E-value: 2.7
       TPR_2   2 ealynlGlayyklgdyeeAleafekAlel 30 
                 + +   +++ y l +y  ++ + ++A+e 
  EFC37578.1 960 DFYLSKARCKYLLRQYIHCVSHIKEAIEV 988
                 6677889999****************985 PP

  == domain 8  score: 4.3 bits;  conditional E-value: 0.076
       TPR_2   13 klgdyeeAleafekAlel 30  
                   ++d+ eA++ f +Al+l
  EFC37578.1 1112 SKNDFYEAIRQFTEALSL 1129
                  6799************98 PP

  == domain 9  score: 18.9 bits;  conditional E-value: 1.6e-06
       TPR_2    2 ealynlGlayyklgdyeeAleafekAleldP 32  
                   ++++++++yy++ ++e+ +e++++A++l+ 
  EFC37578.1 1146 SLYFERAECYYENEEFEKSIEDCRQAVKLES 1176
                  689*************************975 PP

  == domain 10  score: 9.2 bits;  conditional E-value: 0.0021
       TPR_2    4 lynlGlayyklgdyeeAleafekAleldPn 33  
                  +  l +++++ g++ee +e+++ Al+  P 
  EFC37578.1 1182 YVLLCKSLMETGNLEESIELCNSALAQSPF 1211
                  778999********************9995 PP

  == domain 11  score: 12.9 bits;  conditional E-value: 0.00014
       TPR_2    5 ynlGlayyklgdyeeAleafekAleldPnn 34  
                  ++ G+ ++++ +++ A+++++kA++l Pnn
  EFC37578.1 1235 FEEGREAIEAEEFDVAINCLNKAIRLRPNN 1264
                  78899999********************98 PP

  == domain 12  score: 8.0 bits;  conditional E-value: 0.005
       TPR_2    2 ealynlGlayyklgdyeeAleafekAleldPnn 34  
                  e+l ++ +a+++++++++Al++  k+l+ dP+n
  EFC37578.1 1266 EYLLARSKALFERQKFKKALDDSTKVLKFDPKN 1298
                  78999**************************97 PP

  == domain 13  score: 4.9 bits;  conditional E-value: 0.049
       TPR_2    9 layyklgdyeeAleafekAleldPnn 34  
                  +++++l+++ eA+ +++     +Pn+
  EFC37578.1 1307 DIHLELKNFSEAKTLLQNGMDMYPND 1332
                  6899*******************997 PP

  == domain 14  score: 9.7 bits;  conditional E-value: 0.0015
       TPR_2    9 layyklgdyeeAleafekAleld 31  
                  + +y++g+ye+Ale++  A+ l 
  EFC37578.1 1360 EDCYANGNYEQALELYSSAIHLH 1382
                  568**************999875 PP

  == domain 15  score: 8.9 bits;  conditional E-value: 0.0025
       TPR_2    1 aealynlGlayyklgdyeeAleafekAleld 31  
                  a++l++++++++kl ++e Al++ ++Al +d
  EFC37578.1 1386 AQYLCRRARVLLKLSQPEIALKDAQEALLHD 1416
                  6799************************876 PP

  == domain 16  score: 12.0 bits;  conditional E-value: 0.00025
       TPR_2    2 ealynlGlayyklgdyeeAleafekAlel 30  
                  e++  l+ +y++l dye+A+e  e++l  
  EFC37578.1 1420 EVYATLATIYLELCDYEKAKEIIEESLTF 1448
                  68999******************999976 PP

  == domain 17  score: 6.3 bits;  conditional E-value: 0.018
       TPR_2   16 dyeeAleafekAleldPnn 34  
                  d+++A e+f +A+ l+Pnn
  EFC37578.1 1544 DLQKAQELFSEAVLLEPNN 1562
                  89***************98 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.063        43      20      61 ..     371     412 ..     364     419 .. 0.77
   2 ?    3.8   0.0      0.12        83       2      57 ..     647     702 ..     646     709 .. 0.87
   3 ?    3.9   0.0      0.11        78       6      48 ..     685     727 ..     680     732 .. 0.91
   4 !   10.9   0.3   0.00072      0.49      14      60 ..     758     811 ..     753     816 .. 0.71
   5 ?    6.0   0.0     0.025        17       6      41 ..     940     975 ..     939     993 .. 0.91
   6 ?    5.5   0.1     0.036        25       6      44 ..    1115    1164 ..    1111    1166 .. 0.81
   7 !    8.3   0.0    0.0048       3.3      15      56 ..    1169    1210 ..    1165    1215 .. 0.90
   8 ?    6.5   0.0     0.017        12       1      45 [.    1241    1285 ..    1241    1286 .. 0.95
   9 !   20.8   0.0   5.9e-07   0.00041       1      62 [.    1275    1336 ..    1275    1342 .. 0.93
  10 !   10.7   3.9   0.00086      0.59       3      64 ..    1364    1425 ..    1363    1458 .. 0.73
  11 ?    1.8   0.0      0.52   3.6e+02       5      25 ..    1543    1563 ..    1541    1575 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.063
      TPR_19  20 edpknaearllLAeallalgqldeAealLdalpeedpddary 61 
                 ++pkn e     Ae++++l+ +d+A   +++ ++  +dd++ 
  EFC37578.1 371 KNPKNIEQYRTRAECYMKLKMWDKANIDVEEGLKLRHDDSDF 412
                 68999999999**************76666666666665555 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.12
      TPR_19   2 laegdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpd 57 
                 +++ d ++A++ll+++++ +p      ++LA+a +   ++++  +  ++++e++ d
  EFC37578.1 647 MEQSDCDQAIDLLKKVISFEPFGVKYIIALADAFYLKTDYKQCVKYAKKVLEMAVD 702
                 78999****************999999999**999999999999999999998888 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.11
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqldeAealL 48 
                 dy + +++ +++l+ + +++ a +    ++la   +++A++  
  EFC37578.1 685 DYKQCVKYAKKVLEMAVDYWKAYYIIGSCYLAKRKVTKAIEFF 727
                 788889999******************************9975 PP

  == domain 4  score: 10.9 bits;  conditional E-value: 0.00072
      TPR_19  14 leqalqedpk.......naearllLAeallalgqldeAealLdalpeedpdd.ar 60 
                 l+qal+++ k        a++ + +A+ l+++g++++A  +++++ e+dp + ++
  EFC37578.1 758 LKQALKDAEKkketmqkAANLSI-YAKQLFQQGNYEDALLTINEVIEKDPTNiSY 811
                 55565553333344411555555.8*************************97555 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.025
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgql 41 
                 + ++ ++ll +a++ +p++a+  l  A++ + l q+
  EFC37578.1 940 QIEQIVSLLDEAIDLYPHSADFYLSKARCKYLLRQY 975
                 5678999**********************9888776 PP

  == domain 6  score: 5.5 bits;  conditional E-value: 0.036
      TPR_19    6 dyaeAlalleqal...........qedpknaearllLAeallalgqldeA 44  
                  d+ eA++ +++al           q+d ++a +    Ae+++++ ++++ 
  EFC37578.1 1115 DFYEAIRQFTEALslkiedseektQDDRDYASLYFERAECYYENEEFEKS 1164
                  66688888888886666666666677999******************986 PP

  == domain 7  score: 8.3 bits;  conditional E-value: 0.0048
      TPR_19   15 eqalqedpknaearllLAeallalgqldeAealLdalpeedp 56  
                  +qa + +   +    lL++ l+++g+l+e ++l++ ++++ p
  EFC37578.1 1169 RQAVKLESTFPHFYVLLCKSLMETGNLEESIELCNSALAQSP 1210
                  7888999999999***********************999987 PP

  == domain 8  score: 6.5 bits;  conditional E-value: 0.017
      TPR_19    1 llaegdyaeAlalleqalqedpknaearllLAeallalgqldeAe 45  
                  +++++ ++ A++ l +a+   p+n e +l+  +al++   +++A 
  EFC37578.1 1241 AIEAEEFDVAINCLNKAIRLRPNNIEYLLARSKALFERQKFKKAL 1285
                  58999*************************************996 PP

  == domain 9  score: 20.8 bits;  conditional E-value: 5.9e-07
      TPR_19    1 llaegdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddarya 62  
                  l++++++  Al+  +++l+ dpkn  a  l  +++l+l+++ eA+ lL+  ++++p+d+ ++
  EFC37578.1 1275 LFERQKFKKALDDSTKVLKFDPKNIIAIRLHSDIHLELKNFSEAKTLLQNGMDMYPNDQTLR 1336
                  68999****************************************************98765 PP

  == domain 10  score: 10.7 bits;  conditional E-value: 0.00086
      TPR_19    3 aegdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddaryasL 64  
                  a+g+y++Al+l+++a+    + a  + + A++ll+l q++ A +  ++++++d  ++ ya+L
  EFC37578.1 1364 ANGNYEQALELYSSAIHLHDDCAQYLCRRARVLLKLSQPEIALKDAQEALLHDTSEEVYATL 1425
                  89999999999999987744433333345888888888777777777777777776666555 PP

  == domain 11  score: 1.8 bits;  conditional E-value: 0.52
      TPR_19    5 gdyaeAlalleqalqedpkna 25  
                  +d++ A++l+++a   +p+n 
  EFC37578.1 1543 EDLQKAQELFSEAVLLEPNNK 1563
                  689999999999999999986 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.0      0.03        20       4      20 ..     379     395 ..     376     409 .. 0.79
   2 ?    0.4   0.1      0.93   6.4e+02       3      24 ..     457     478 ..     456     482 .. 0.87
   3 ?   -0.9   0.0       2.5   1.7e+03      18      32 ..     653     667 ..     647     668 .. 0.87
   4 ?    0.3   0.8         1     7e+02       7      30 ..     676     699 ..     674     703 .. 0.85
   5 !   11.9   0.1   0.00022      0.15       2      29 ..     705     732 ..     704     735 .. 0.91
   6 !   11.1   0.0    0.0004      0.27      11      34 .]     785     808 ..     782     808 .. 0.94
   7 ?   -1.4   0.0       3.6   2.5e+03       2      34 .]     844     876 ..     843     876 .. 0.85
   8 ?   -0.5   0.1       1.8   1.3e+03       1      30 [.     959     988 ..     959     989 .. 0.93
   9 ?    2.7   0.0      0.17   1.2e+02      13      30 ..    1112    1129 ..    1107    1131 .. 0.90
  10 !   22.0   0.1   1.4e-07   9.9e-05       1      33 [.    1145    1177 ..    1145    1178 .. 0.92
  11 ?    5.5   0.0     0.024        16       7      33 ..    1185    1211 ..    1181    1212 .. 0.86
  12 !    7.8   0.0    0.0045       3.1      17      34 .]    1247    1264 ..    1238    1264 .. 0.87
  13 ?    6.5   0.1     0.011       7.6      10      34 .]    1274    1298 ..    1273    1298 .. 0.95
  14 ?   -0.7   0.0       2.1   1.4e+03      10      34 .]    1308    1332 ..    1307    1332 .. 0.88
  15 !   11.1   0.4    0.0004      0.27      11      31 ..    1362    1382 ..    1355    1385 .. 0.88
  16 !    9.7   0.1    0.0011      0.74       1      30 [.    1386    1415 ..    1386    1416 .. 0.92
  17 !    8.8   0.1    0.0021       1.4       2      31 ..    1420    1449 ..    1419    1451 .. 0.88
  18 ?    3.9   0.1     0.074        51      15      34 .]    1543    1562 ..    1541    1562 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.03
                 HHHHHHHHHHTT-HHHH CS
       TPR_1   4 lynlGnayfklgkydeA 20 
                 +  ++ +y+kl+++d+A
  EFC37578.1 379 YRTRAECYMKLKMWDKA 395
                 6679************9 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.93
                 HHHHHHHHHHHTT-HHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyy 24 
                 +++ ++ +  k  +++eA+ + 
  EFC37578.1 457 SYKIRAKCRIKERNFNEAINDA 478
                 6888999************885 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 2.5
                 HHHHHHHHHHHHHST CS
       TPR_1  18 deAleyyekALelnP 32 
                 d+A++  +k+++ +P
  EFC37578.1 653 DQAIDLLKKVISFEP 667
                 89********99887 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 1
                 HHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   7 lGnayfklgkydeAleyyekALel 30 
                 l+ a++ + +y+++++y +k+Le 
  EFC37578.1 676 LADAFYLKTDYKQCVKYAKKVLEM 699
                 6777888889************97 PP

  == domain 5  score: 11.9 bits;  conditional E-value: 0.00022
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALe 29 
                 ka+y +G +y+ + k  +A+e++ + +e
  EFC37578.1 705 KAYYIIGSCYLAKRKVTKAIEFFGQGVE 732
                 8*********************987665 PP

  == domain 6  score: 11.1 bits;  conditional E-value: 0.0004
                 HHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1  11 yfklgkydeAleyyekALelnPnn 34 
                 +f++g+y++Al   ++++e +P+n
  EFC37578.1 785 LFQQGNYEDALLTINEVIEKDPTN 808
                 79********************98 PP

  == domain 7  score: -1.4 bits;  conditional E-value: 3.6
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                 + +   G+a++ l++y   +   e A +  P+n
  EFC37578.1 844 EGYLCQGVALQFLNRYHHSITVLEAAMRMFPEN 876
                 678899**********99999988888888876 PP

  == domain 8  score: -0.5 bits;  conditional E-value: 1.8
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayfklgkydeAleyyekALel 30 
                 a+ +  ++ + + l +y  ++ + ++A+e+
  EFC37578.1 959 ADFYLSKARCKYLLRQYIHCVSHIKEAIEV 988
                 688999**********************95 PP

  == domain 9  score: 2.7 bits;  conditional E-value: 0.17
                  HTT-HHHHHHHHHHHHHH CS
       TPR_1   13 klgkydeAleyyekALel 30  
                  +++++ eA+  + +AL+l
  EFC37578.1 1112 SKNDFYEAIRQFTEALSL 1129
                  679*************98 PP

  == domain 10  score: 22.0 bits;  conditional E-value: 1.4e-07
                  HHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1    1 akalynlGnayfklgkydeAleyyekALelnPn 33  
                  a  ++ ++ +y++++++++ +e++++A++l+ +
  EFC37578.1 1145 ASLYFERAECYYENEEFEKSIEDCRQAVKLEST 1177
                  5689**************************876 PP

  == domain 11  score: 5.5 bits;  conditional E-value: 0.024
                  HHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1    7 lGnayfklgkydeAleyyekALelnPn 33  
                  l   +++ g+++e +e ++ AL   P 
  EFC37578.1 1185 LCKSLMETGNLEESIELCNSALAQSPF 1211
                  66789999**************99885 PP

  == domain 12  score: 7.8 bits;  conditional E-value: 0.0045
                  HHHHHHHHHHHHHHSTTH CS
       TPR_1   17 ydeAleyyekALelnPnn 34  
                  +d A+ + +kA++l+Pnn
  EFC37578.1 1247 FDVAINCLNKAIRLRPNN 1264
                  5559*************8 PP

  == domain 13  score: 6.5 bits;  conditional E-value: 0.011
                  HHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   10 ayfklgkydeAleyyekALelnPnn 34  
                  a+f+ +k+++Al++  k+L+ +P+n
  EFC37578.1 1274 ALFERQKFKKALDDSTKVLKFDPKN 1298
                  78999******************98 PP

  == domain 14  score: -0.7 bits;  conditional E-value: 2.1
                  HHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   10 ayfklgkydeAleyyekALelnPnn 34  
                  ++++l+++ eA    +     +Pn+
  EFC37578.1 1308 IHLELKNFSEAKTLLQNGMDMYPND 1332
                  6899********9999998888886 PP

  == domain 15  score: 11.1 bits;  conditional E-value: 0.0004
                  HHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   11 yfklgkydeAleyyekALeln 31  
                  ++ +g+y++Ale y+ A+ l 
  EFC37578.1 1362 CYANGNYEQALELYSSAIHLH 1382
                  7999**************986 PP

  == domain 16  score: 9.7 bits;  conditional E-value: 0.0011
                  HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1    1 akalynlGnayfklgkydeAleyyekALel 30  
                  a+ l++++ +++kl +++ Al++ ++AL +
  EFC37578.1 1386 AQYLCRRARVLLKLSQPEIALKDAQEALLH 1415
                  6789***********************966 PP

  == domain 17  score: 8.8 bits;  conditional E-value: 0.0021
                  HHHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1    2 kalynlGnayfklgkydeAleyyekALeln 31  
                  +++  l+ +y++l +y++A e  e+ L+ +
  EFC37578.1 1420 EVYATLATIYLELCDYEKAKEIIEESLTFD 1449
                  57899***************9998888765 PP

  == domain 18  score: 3.9 bits;  conditional E-value: 0.074
                  T-HHHHHHHHHHHHHHSTTH CS
       TPR_1   15 gkydeAleyyekALelnPnn 34  
                  +++++A e +++A+ l+Pnn
  EFC37578.1 1543 EDLQKAQELFSEAVLLEPNN 1562
                  689****************8 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0    0.0038       2.6       2      57 ..     675     727 ..     674     729 .. 0.92
   2 ?    4.5   0.0     0.083        57       7      31 ..     785     806 ..     782     841 .. 0.82
   3 ?    0.4   0.0       1.6   1.1e+03      19      43 ..     947     968 ..     945     989 .. 0.89
   4 !    8.3   0.0    0.0051       3.5      28      62 ..    1139    1173 ..    1114    1179 .. 0.82
   5 !   12.4   0.0   0.00027      0.19       7      67 ..    1155    1212 ..    1149    1213 .. 0.92
   6 !   13.2   0.0   0.00016      0.11       2      55 ..    1236    1286 ..    1235    1298 .. 0.89
   7 !   16.4   0.6   1.6e-05     0.011       8      60 ..    1363    1413 ..    1359    1420 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0038
      TPR_16   2 alaraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaaly 57 
                 ala+a++   dy + +++++ +l+++    d + A++  g ++l++  +++A++++
  EFC37578.1 675 ALADAFYLKTDYKQCVKYAKKVLEMA---VDYWKAYYIIGSCYLAKRKVTKAIEFF 727
                 7888888888999999999*******...************************987 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.083
      TPR_16   7 alragdyddAaaaleaalkrdpssP 31 
                 ++++g+y+dA+   ++++++d   P
  EFC37578.1 785 LFQQGNYEDALLTINEVIEKD---P 806
                 789999999999999998888...5 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 1.6
      TPR_16  19 aleaalkrdpssPdaaeAllllgda 43 
                 +l++a++++   P  a+++l ++++
  EFC37578.1 947 LLDEAIDLY---PHSADFYLSKARC 968
                 7899*****...**********999 PP

  == domain 4  score: 8.3 bits;  conditional E-value: 0.0051
      TPR_16   28 pssPdaaeAllllgdaalrqgrlaeAaalyraalr 62  
                   ++ d a  +++++++++++ ++++ ++ +r a++
  EFC37578.1 1139 QDDRDYASLYFERAECYYENEEFEKSIEDCRQAVK 1173
                  46678**********************99999875 PP

  == domain 5  score: 12.4 bits;  conditional E-value: 0.00027
      TPR_16    7 alragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapda 67  
                  ++++ ++++ ++  ++a+k+ +  P    ++ ll  ++ + g+l+e ++l+++al+++p++
  EFC37578.1 1155 YYENEEFEKSIEDCRQAVKLESTFPH---FYVLLCKSLMETGNLEESIELCNSALAQSPFN 1212
                  99*******************76666...*****************************986 PP

  == domain 6  score: 13.2 bits;  conditional E-value: 0.00016
      TPR_16    2 alaraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaa 55  
                  +++r+a++a ++d A++ l+ a++++   P + e ll++  a+++++ +++A++
  EFC37578.1 1236 EEGREAIEAEEFDVAINCLNKAIRLR---PNNIEYLLARSKALFERQKFKKALD 1286
                  689***********************...***********************94 PP

  == domain 7  score: 16.4 bits;  conditional E-value: 1.6e-05
      TPR_16    8 lragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAa.alyraa 60  
                  +++g+y++A++++  a+ ++    d+a+ l  +++++l+++  + A+ ++ +a+
  EFC37578.1 1363 YANGNYEQALELYSSAIHLH---DDCAQYLCRRARVLLKLSQPEIALkDAQEAL 1413
                  789*****************...*****************99998886665555 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       4.8   3.3e+03      12      32 ..     647     667 ..     643     679 .. 0.82
   2 !    8.4   0.0    0.0062       4.3       6      35 ..     780     809 ..     775     816 .. 0.90
   3 ?    1.8   0.0      0.85   5.9e+02      16      43 ..     940     967 ..     937     968 .. 0.87
   4 ?   -1.4   0.0       8.8     6e+03       8      27 ..    1035    1054 ..    1030    1059 .. 0.90
   5 ?    3.2   0.0      0.29     2e+02       3      41 ..    1147    1185 ..    1145    1188 .. 0.84
   6 ?    7.3   0.0     0.014       9.6       4      32 ..    1182    1210 ..    1179    1220 .. 0.85
   7 ?    7.7   0.0      0.01       7.1      12      41 ..    1242    1271 ..    1238    1274 .. 0.87
   8 ?    0.9   0.0       1.6   1.1e+03       3      35 ..    1267    1299 ..    1265    1306 .. 0.83
   9 ?    3.8   0.0      0.19   1.3e+02      10      41 ..    1308    1339 ..    1301    1340 .. 0.93
  10 ?    7.0   0.3     0.018        12       8      43 ..    1359    1394 ..    1351    1395 .. 0.84
  11 ?    2.4   0.2      0.54   3.7e+02       6      39 ..    1391    1423 ..    1386    1428 .. 0.77
  12 ?    2.3   0.0      0.56   3.9e+02       2      39 ..    1420    1457 ..    1419    1461 .. 0.82
  13 ?   -0.2   0.0       3.7   2.5e+03      15      40 ..    1543    1568 ..    1540    1571 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 4.8
      TPR_14  12 lalGdpdeAiallrralalaP 32 
                 +++ d d+Ai+ll+++++  P
  EFC37578.1 647 MEQSDCDQAIDLLKKVISFEP 667
                 6777889*********99877 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0062
      TPR_14   6 alaeallalGdpdeAiallrralalaPdda 35 
                  +a+ l+++G++++A+   +++++++P++ 
  EFC37578.1 780 IYAKQLFQQGNYEDALLTINEVIEKDPTNI 809
                 699************************985 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.85
      TPR_14  16 dpdeAiallrralalaPddaeawlllaq 43 
                 + ++ + ll++a++l+P +a+++l  a+
  EFC37578.1 940 QIEQIVSLLDEAIDLYPHSADFYLSKAR 967
                 5678889**************9998887 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 8.8
      TPR_14    8 aeallalGdpdeAiallrra 27  
                  a+a+   +++d A ++l+++
  EFC37578.1 1035 ARAYTSMRQFDIATNYLKDM 1054
                  899**************997 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.29
      TPR_14    3 allalaeallalGdpdeAiallrralalaPddaeawlll 41  
                  ++ ++ae ++++++++++i+ +r+a++l  +++ ++ ll
  EFC37578.1 1147 LYFERAECYYENEEFEKSIEDCRQAVKLESTFPHFYVLL 1185
                  67899*********************9877776666655 PP

  == domain 6  score: 7.3 bits;  conditional E-value: 0.014
      TPR_14    4 llalaeallalGdpdeAiallrralalaP 32  
                  + +l + l++ G+++e+i+l++ ala+ P
  EFC37578.1 1182 YVLLCKSLMETGNLEESIELCNSALAQSP 1210
                  56777889*******************99 PP

  == domain 7  score: 7.7 bits;  conditional E-value: 0.01
      TPR_14   12 lalGdpdeAiallrralalaPddaeawlll 41  
                   +++++d Ai++l++a++l P++ e++l+ 
  EFC37578.1 1242 IEAEEFDVAINCLNKAIRLRPNNIEYLLAR 1271
                  57899******************9999876 PP

  == domain 8  score: 0.9 bits;  conditional E-value: 1.6
      TPR_14    3 allalaeallalGdpdeAiallrralalaPdda 35  
                   lla+ +al++++++++A++   ++l+ +P++ 
  EFC37578.1 1267 YLLARSKALFERQKFKKALDDSTKVLKFDPKNI 1299
                  689999************999988999999885 PP

  == domain 9  score: 3.8 bits;  conditional E-value: 0.19
      TPR_14   10 allalGdpdeAiallrralalaPddaeawlll 41  
                  ++l+l ++ eA +ll+   + +P+d++++l+l
  EFC37578.1 1308 IHLELKNFSEAKTLLQNGMDMYPNDQTLRLRL 1339
                  68999************************997 PP

  == domain 10  score: 7.0 bits;  conditional E-value: 0.018
      TPR_14    8 aeallalGdpdeAiallrralalaPddaeawlllaq 43  
                  ae ++a+G++++A++l+  a+ l+ d a+++ + a+
  EFC37578.1 1359 AEDCYANGNYEQALELYSSAIHLHDDCAQYLCRRAR 1394
                  666899******************999999988887 PP

  == domain 11  score: 2.4 bits;  conditional E-value: 0.54
      TPR_14    6 alaeallalGdpdeAiallrralalaPddaeawl 39  
                  ++a++ll l +p+ A++ +++al ++ + +e++ 
  EFC37578.1 1391 RRARVLLKLSQPEIALKDAQEALLHDTS-EEVYA 1423
                  67********************986655.44444 PP

  == domain 12  score: 2.3 bits;  conditional E-value: 0.56
      TPR_14    2 eallalaeallalGdpdeAiallrralalaPddaeawl 39  
                  e+++ la ++l+l d+++A ++ ++ l  + ++a  +l
  EFC37578.1 1420 EVYATLATIYLELCDYEKAKEIIEESLTFDDEEAMDNL 1457
                  67899********************9987766665554 PP

  == domain 13  score: -0.2 bits;  conditional E-value: 3.7
      TPR_14   15 GdpdeAiallrralalaPddaeawll 40  
                  +d+++A +l+ +a+ l P++ +++++
  EFC37578.1 1543 EDLQKAQELFSEAVLLEPNNKRYLRH 1568
                  58999**************9988765 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.65   4.5e+02       5      39 ..     647     681 ..     644     683 .. 0.79
   2 !   11.4   0.1   0.00028       0.2       2      30 ..     783     811 ..     782     814 .. 0.91
   3 ?   -1.7   0.1       3.6   2.5e+03      18      32 ..     949     963 ..     946     966 .. 0.86
   4 ?   -1.1   0.0       2.3   1.6e+03       6      24 ..    1112    1130 ..    1111    1133 .. 0.89
   5 ?    1.6   0.1      0.32   2.2e+02      24      41 ..    1141    1158 ..    1139    1159 .. 0.91
   6 !    9.5   0.0    0.0011      0.75       4      40 ..    1155    1191 ..    1152    1193 .. 0.88
   7 ?    0.9   0.0      0.54   3.7e+02       4      25 ..    1189    1210 ..    1187    1212 .. 0.88
   8 !   18.0   0.1   2.4e-06    0.0017       6      39 ..    1243    1276 ..    1238    1278 .. 0.86
   9 ?    4.2   0.0      0.05        35       3      29 ..    1274    1300 ..    1272    1302 .. 0.93
  10 !   13.9   0.4   4.7e-05     0.033       4      41 ..    1362    1399 ..    1359    1400 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.65
      TPR_11   5 yeqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 +eq + ++Ai  +kk + + P  +    +L++a+y
  EFC37578.1 647 MEQSDCDQAIDLLKKVISFEPFGVKYIIALADAFY 681
                 688899************99977766666666666 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00028
      TPR_11   2 dayyeqGkyeeAieaYkkAlkldPdnaea 30 
                 + +++qG+ye+A+   ++ ++ dP+n + 
  EFC37578.1 783 KQLFQQGNYEDALLTINEVIEKDPTNISY 811
                 579***********************876 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 3.6
      TPR_11  18 kkAlkldPdnaeayy 32 
                  +A++l P +a++y+
  EFC37578.1 949 DEAIDLYPHSADFYL 963
                 689*********997 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 2.3
      TPR_11    6 eqGkyeeAieaYkkAlkld 24  
                  +++++ eAi ++ +Al l+
  EFC37578.1 1112 SKNDFYEAIRQFTEALSLK 1130
                  689999**********986 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.32
      TPR_11   24 dPdnaeayynLGlayykq 41  
                  d d+a++y+++++ yy++
  EFC37578.1 1141 DRDYASLYFERAECYYEN 1158
                  89**************86 PP

  == domain 6  score: 9.5 bits;  conditional E-value: 0.0011
      TPR_11    4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40  
                  yye  ++e++ie+ ++A+kl ++++ +y  L + +++
  EFC37578.1 1155 YYENEEFEKSIEDCRQAVKLESTFPHFYVLLCKSLME 1191
                  9**************************9888666665 PP

  == domain 7  score: 0.9 bits;  conditional E-value: 0.54
      TPR_11    4 yyeqGkyeeAieaYkkAlkldP 25  
                  ++e G++ee+ie  + Al+ +P
  EFC37578.1 1189 LMETGNLEESIELCNSALAQSP 1210
                  7899********9999999887 PP

  == domain 8  score: 18.0 bits;  conditional E-value: 2.4e-06
      TPR_11    6 eqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39  
                  e  +++ Ai++++kA++l+P+n e ++++ +a++
  EFC37578.1 1243 EAEEFDVAINCLNKAIRLRPNNIEYLLARSKALF 1276
                  6678999******************999988876 PP

  == domain 9  score: 4.2 bits;  conditional E-value: 0.05
      TPR_11    3 ayyeqGkyeeAieaYkkAlkldPdnae 29  
                  a++e++k+++A+ +  k lk+dP+n  
  EFC37578.1 1274 ALFERQKFKKALDDSTKVLKFDPKNII 1300
                  89**********************975 PP

  == domain 10  score: 13.9 bits;  conditional E-value: 4.7e-05
      TPR_11    4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlayykq 41  
                  +y+ G+ye+A+e Y+ A+ l  d a  ++ ++ +++k+
  EFC37578.1 1362 CYANGNYEQALELYSSAIHLHDDCAQYLCRRARVLLKL 1399
                  79******************999999999988888775 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.85   5.9e+02      51      75 ..     371     395 ..     360     400 .. 0.71
   2 !   17.4   0.5   5.6e-06    0.0039       2      80 ..     649     728 ..     648     730 .. 0.92
   3 !   11.4   0.3   0.00043       0.3       4      49 ..     757     801 ..     756     830 .. 0.66
   4 ?    0.1   0.2       1.4   9.4e+02       6      49 ..     860     910 ..     856     923 .. 0.73
   5 ?    1.0   0.1      0.72     5e+02      48      80 ..     950     983 ..     939     994 .. 0.49
   6 !   15.1   0.9     3e-05      0.02      18      77 ..    1139    1200 ..    1113    1205 .. 0.80
   7 !   18.4   0.2   2.7e-06    0.0018       4      81 ..    1246    1324 ..    1223    1325 .. 0.88
   8 ?    6.7   3.6     0.012       8.3      13      75 ..    1340    1405 ..    1333    1412 .. 0.80
   9 !    7.3   4.7    0.0077       5.3       2      81 ..    1365    1444 ..    1364    1445 .. 0.87
  10 ?    2.5   0.2      0.25   1.7e+02      20      49 ..    1415    1445 ..    1403    1458 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.85
                 HHHC-HHHHHHHHHHHHHTT-HHHH CS
      ANAPC3  51 lnskslgcrylfAqcllkLkkyeeA 75 
                 +n+k+++   + A+c+ kLk +++A
  EFC37578.1 371 KNPKNIEQYRTRAECYMKLKMWDKA 395
                 3566666677777777777777766 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 5.6e-06
                 TT-HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH- CS
      ANAPC3   2 qnnyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaLe 80 
                 q + + Ai l+ ++ + e+   + + +lA ++yl  +yk++ ++++k  + +    ++ y+++ c+l+  k+ +Ai  ++
  EFC37578.1 649 QSDCDQAIDLLKKVISFEPFGVKYIIALADAFYLKTDYKQCVKYAKKVlEMAVDYWKAYYIIGSCYLAKRKVTKAIEFFG 728
                 667788999999999999******************************78878888********************9886 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 0.00043
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclylngqykrAyellrka 49 
                 ++k A+  ae+      + + ++  +A+ l+++g+y+ A+  +++ 
  EFC37578.1 757 QLKQALKDAEKKK-ETMQKAANLSIYAKQLFQQGNYEDALLTINEV 801
                 5566666666666.55566666666777777777777777777666 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 1.4
                 HHHHHHHHHHH...HHH--HHHHHHHHHHHHHTT-.....HHHHHHHHHCT CS
      ANAPC3   6 knAiflaerlla..aetespedayllAlclylngq.....ykrAyellrka 49 
                 +  i ++e ++    e+ + ++ +++++ ly+ +q     y+rA+ ++++ 
  EFC37578.1 860 HHSITVLEAAMRmfPENSNIKSQFMKSKDLYKKKQlaqmkYERALFIFQDV 910
                 555555555554236666777899999999999988888899999998877 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.72
                 CT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH- CS
      ANAPC3  48 ka.klnskslgcrylfAqcllkLkkyeeAiaaLe 80 
                 +a +l+++s    + +A+c + L +y  ++++++
  EFC37578.1 950 EAiDLYPHSADFYLSKARCKYLLRQYIHCVSHIK 983
                 4444444444444444444444444433333332 PP

  == domain 6  score: 15.1 bits;  conditional E-value: 3e-05
                  HHH--HHHHHHH.HHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHH CS
      ANAPC3   18 aetespedayll.AlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAia 77  
                  ++ +++ ++y+  A+c+y+n+++++ +e +r+a kl+s+ +   +l+ ++l + +++ee i 
  EFC37578.1 1139 QDDRDYASLYFErAECYYENEEFEKSIEDCRQAvKLESTFPHFYVLLCKSLMETGNLEESIE 1200
                  3344444555548*********************************************9987 PP

  == domain 7  score: 18.4 bits;  conditional E-value: 2.7e-06
                  -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3    4 nyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaLek 81  
                   ++ Ai +++++    +++ e +++ +++l++++++k+A++   k  k ++k++ +  l+    l+Lk++ eA ++L++
  EFC37578.1 1246 EFDVAINCLNKAIRLRPNNIEYLLARSKALFERQKFKKALDDSTKVlKFDPKNIIAIRLHSDIHLELKNFSEAKTLLQN 1324
                  46668888888887778888888888************************************************99985 PP

  == domain 8  score: 6.7 bits;  conditional E-value: 0.012
                  HHHH.HHH--HHHHHHH...HHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHH CS
      ANAPC3   13 erllaaetespedayll...AlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeA 75  
                  e+l  +     + ayl    A+  y ng+y++A+el+++a  l +   +++   A++llkL++ e A
  EFC37578.1 1340 EKLI-RIESQWNEAYLRardAEDCYANGNYEQALELYSSAiHLHDDCAQYLCRRARVLLKLSQPEIA 1405
                  5555.4444556677755669999****************999999999999999******987655 PP

  == domain 9  score: 7.3 bits;  conditional E-value: 0.0077
                  TT-HHHHHHHHHHHH.HHH--HHHHHHH..HHHHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3    2 qnnyknAiflaerllaaetespedayll..AlclylngqykrAyellrkaklnskslgcrylfAqcllkLkkyeeAiaaLek 81  
                  ++ny+ A+ l++ +   + +++ + yl   A +l++++q + A++ +++a l ++s+++  ++A  +l+L  ye+A  ++e+
  EFC37578.1 1365 NGNYEQALELYSSAI--HLHDDCAQYLCrrARVLLKLSQPEIALKDAQEALLHDTSEEVYATLATIYLELCDYEKAKEIIEE 1444
                  789999999999999..4555555666467*********************************************9888875 PP

  == domain 10  score: 2.5 bits;  conditional E-value: 0.25
                  H--HHHHHH.HHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3   20 tespedayl.lAlclylngqykrAyellrka 49  
                  ++ +e +y+ lA  ++++ +y++A e+++++
  EFC37578.1 1415 HDTSEEVYAtLATIYLELCDYEKAKEIIEES 1445
                  44556666647**************999987 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.1   7.6e-08   5.3e-05      15      43 ..       2      30 ..       1      30 [. 0.95
   2 !   10.3   0.0   0.00059      0.41      23      45 ..     115     137 ..     101     138 .. 0.88
   3 !   14.5   0.0   2.8e-05     0.019       3      45 ..     217     259 ..     215     260 .. 0.93
   4 ?   -0.6   0.1       1.4   9.9e+02      10      22 ..     280     292 ..     279     304 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 7.6e-08
                EEEEEBCSSSBEEEEEEEETTTTEEEEEC CS
     Kelch_1 15 YviGGsdggnalssvevyDpetntWrelp 43
                 v+GG++g+++l +++++D+et+ W++++
  EFC37578.1  2 WVFGGYSGSEPLADFWCLDLETKIWTQVA 30
                79************************986 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00059
                 SSBEEEEEEEETTTTEEEEECCC CS
     Kelch_1  23 gnalssvevyDpetntWrelpsM 45 
                 g++ ++v+ ++++t +W++l++ 
  EFC37578.1 115 GTCFNDVWSFSFTTSKWHCLTDP 137
                 6889***************9875 PP

  == domain 3  score: 14.5 bits;  conditional E-value: 2.8e-05
                 BSEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEEECCC CS
     Kelch_1   3 agagavvvggkiYviGGsdggnalssvevyDpetntWrelpsM 45 
                 + a++   +g+i ++GG ++++  +++ ++D+++ ++ +lp M
  EFC37578.1 217 SSAAVNIGRGCILIFGGVRDYTHRRDCHILDLVNESFVPLPRM 259
                 678899999********************************99 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 1.4
                 ETTEEEEEEEBCS CS
     Kelch_1  10 vggkiYviGGsdg 22 
                  ++++Yv GGs++
  EFC37578.1 280 SDDCVYVNGGSNF 292
                 699*********9 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.5      0.12        80       5      31 ..     674     700 ..     670     702 .. 0.88
   2 !    9.7   0.1    0.0016       1.1       2      28 ..     705     731 ..     705     734 .. 0.91
   3 ?   -0.3   0.0       2.4   1.7e+03      11      33 ..     785     807 ..     782     808 .. 0.87
   4 ?    3.6   0.0      0.14        93       8      34 .]     850     876 ..     843     876 .. 0.88
   5 ?    0.6   0.1       1.3   8.7e+02      12      31 ..    1111    1130 ..    1102    1130 .. 0.88
   6 !   12.7   0.2   0.00016      0.11       1      32 [.    1145    1176 ..    1145    1178 .. 0.93
   7 ?    3.7   0.0      0.13        88       4      33 ..    1182    1211 ..    1179    1212 .. 0.82
   8 !    7.7   0.0    0.0066       4.6      11      34 .]    1241    1264 ..    1235    1264 .. 0.85
   9 ?    1.9   0.1      0.49   3.4e+02       2      34 .]    1266    1298 ..    1265    1298 .. 0.92
  10 ?    2.3   0.0      0.35   2.4e+02       8      34 .]    1306    1332 ..    1304    1332 .. 0.88
  11 ?   -1.2   0.1       4.8   3.3e+03      14      28 ..    1365    1379 ..    1363    1381 .. 0.79
  12 ?   -0.4   0.1       2.7   1.8e+03       1      28 [.    1386    1413 ..    1386    1414 .. 0.92
  13 !   14.5   0.2   4.5e-05     0.031       2      31 ..    1420    1449 ..    1419    1452 .. 0.93
  14 ?    0.4   0.0       1.5     1e+03      16      34 .]    1544    1562 ..    1543    1562 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.12
                 HHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekaleld 31 
                   l+++   + dy++ ++y +k+le++
  EFC37578.1 674 IALADAFYLKTDYKQCVKYAKKVLEMA 700
                 6799999999**************985 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0016
                 CHHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekal 28 
                 +ayy +gs+yl + +  +A+e++ + +
  EFC37578.1 705 KAYYIIGSCYLAKRKVTKAIEFFGQGV 731
                 69********************98766 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 2.4
                 HHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8  11 ylklgdyeeAkeyyekaleldpd 33 
                 ++++g+ye A  ++++++e dp+
  EFC37578.1 785 LFQQGNYEDALLTINEVIEKDPT 807
                 5799***********99997776 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.14
                 HHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   8 gsiylklgdyeeAkeyyekaleldpdn 34 
                 g +++ l++y+ ++ ++e a ++ p+n
  EFC37578.1 850 GVALQFLNRYHHSITVLEAAMRMFPEN 876
                 78999****************999875 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 1.3
                  HHTT-HHHHHHHHHHHHHHH CS
       TPR_8   12 lklgdyeeAkeyyekaleld 31  
                  ++++d+ eA+  + +al+l+
  EFC37578.1 1111 KSKNDFYEAIRQFTEALSLK 1130
                  6899*************985 PP

  == domain 6  score: 12.7 bits;  conditional E-value: 0.00016
                  CCHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8    1 aeayynlgsiylklgdyeeAkeyyekaleldp 32  
                  a++y+  + +y + +++e+++e +++a++l+ 
  EFC37578.1 1145 ASLYFERAECYYENEEFEKSIEDCRQAVKLES 1176
                  679**************************975 PP

  == domain 7  score: 3.7 bits;  conditional E-value: 0.13
                  HHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8    4 yynlgsiylklgdyeeAkeyyekaleldpd 33  
                  y++l + ++++g++ee++e ++ al  +p 
  EFC37578.1 1182 YVLLCKSLMETGNLEESIELCNSALAQSPF 1211
                  566667899*************99987775 PP

  == domain 8  score: 7.7 bits;  conditional E-value: 0.0066
                  HHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   11 ylklgdyeeAkeyyekaleldpdn 34  
                   ++ ++++ A+ +++ka++l+p+n
  EFC37578.1 1241 AIEAEEFDVAINCLNKAIRLRPNN 1264
                  566788999*************97 PP

  == domain 9  score: 1.9 bits;  conditional E-value: 0.49
                  CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8    2 eayynlgsiylklgdyeeAkeyyekaleldpdn 34  
                  e+++  ++++++ +++++A     k+l+ dp+n
  EFC37578.1 1266 EYLLARSKALFERQKFKKALDDSTKVLKFDPKN 1298
                  678889999**********************97 PP

  == domain 10  score: 2.3 bits;  conditional E-value: 0.35
                  HHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8    8 gsiylklgdyeeAkeyyekaleldpdn 34  
                  ++i+l+l+++ eAk  ++   ++ p++
  EFC37578.1 1306 SDIHLELKNFSEAKTLLQNGMDMYPND 1332
                  689************999999888875 PP

  == domain 11  score: -1.2 bits;  conditional E-value: 4.8
                  TT-HHHHHHHHHHHH CS
       TPR_8   14 lgdyeeAkeyyekal 28  
                   g+ye+A e y  a+
  EFC37578.1 1365 NGNYEQALELYSSAI 1379
                  689999999887665 PP

  == domain 12  score: -0.4 bits;  conditional E-value: 2.7
                  CCHHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8    1 aeayynlgsiylklgdyeeAkeyyekal 28  
                  a+++++ ++++lkl + e A +  ++al
  EFC37578.1 1386 AQYLCRRARVLLKLSQPEIALKDAQEAL 1413
                  6899****************99999987 PP

  == domain 13  score: 14.5 bits;  conditional E-value: 4.5e-05
                  CHHHHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8    2 eayynlgsiylklgdyeeAkeyyekaleld 31  
                  e+y  l+ iyl+l dye+Ake +e+ l+ d
  EFC37578.1 1420 EVYATLATIYLELCDYEKAKEIIEESLTFD 1449
                  79************************9877 PP

  == domain 14  score: 0.4 bits;  conditional E-value: 1.5
                  -HHHHHHHHHHHHHHHHH. CS
       TPR_8   16 dyeeAkeyyekaleldpdn 34  
                  d+++A+e + +a+ l+p+n
  EFC37578.1 1544 DLQKAQELFSEAVLLEPNN 1562
                  899**************97 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   0.0   2.9e-09     2e-06       4      47 ..       1      46 [.       1      47 [. 0.91
   2 !    7.1   0.1    0.0099       6.9      13      32 ..     113     132 ..     108     141 .. 0.85
   3 ?    0.2   0.0       1.5     1e+03       4      44 ..     228     273 ..     226     277 .. 0.76

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 2.9e-09
     Kelch_3  4 lyifGGlgddgqdrlndvyvydldtntWaei..asl..ppaRaghaat 47
                +++fGG+   g ++l d++ +dl+t  W+++  +++  p aR+gh+++
  EFC37578.1  1 MWVFGGYS--GSEPLADFWCLDLETKIWTQVafDRTkaPEARYGHSGV 46
                89******..***********************5544499******86 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0099
     Kelch_3  13 dgqdrlndvyvydldtntWa 32 
                 +g+++ ndv+++++ t +W 
  EFC37578.1 113 IGGTCFNDVWSFSFTTSKWH 132
                 589***************96 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 1.5
     Kelch_3   4 lyifGGlgddgqdrlndvyvydldtntWaei.......aslppaRagh 44 
                 ++ifGG +    ++  d + +dl+++++  +       +s+p+aR gh
  EFC37578.1 228 ILIFGGVR--DYTHRRDCHILDLVNESFVPLprmiklnDSWPTARKGH 273
                 77888877..3555588888999999999665556889999**99877 PP

>> GRAM  GRAM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.9   2.6e-06    0.0018      45     110 ..    3062    3127 ..    3060    3131 .. 0.85
   2 !   23.9   2.5   4.1e-08   2.9e-05       4     109 ..    3178    3280 ..    3175    3285 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 2.6e-06
                  EE-STT---E...EEEEGGGEEEEEE....-TT-TT-EEEEESS-..EEEEE--TTHHHHHHHHHHHHH CS
        GRAM   45 rskplgsskk...vvlpladikriekstsaanllengiqvetsskdlelaFagfvtrdeaiefieellk 110 
                  +s p +++++   + + + +ik++ +st++a  l+n+i+v  s+k  e++F+ f++r++a+e+i++++ 
  EFC37578.1 3062 TSEP-QYNTQidyIKISIGKIKSVFRSTFGAGALDNSITVSKSEK--EFQFSCFKDREKAFEVIQTFIL 3127
                  5554.555555567889****************************..8****************99765 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 4.1e-08
                  HHHS----TT--EEEEEEEEEESS.SEEEEEEEEESSEEEEEE-STT---E.EEEEGGGEEEEEE....-TT-TT-EEEEESS-..EEEEE--TTHH CS
        GRAM    4 rkkfkellpeEkllatykCyllrdggpvqGrlyltnyrlcFrskplgsskk.vvlpladikriekstsaanllengiqvetsskdlelaFagfvtrd 99  
                  rk+f+ l pe +l+++y+C+   d     G  y+ + +lcF+      s+  ++lp++++++i+k  +++    + iq++  + +  ++F  f++ +
  EFC37578.1 3178 RKTFN-LKPETRLFNKYSCTDY-D-TKLIGEFYIFTDCLCFTTTVNSGSCLkMILPYSQLVKISKVGKRNMSNRQCIQLTNDKRV-SYSFVNFKNVE 3270
                  899**.*************988.4.6999*************998765555599***********77777777788888777776.*******9999 PP

                  HHHHHHHHHH CS
        GRAM  100 eaiefieell 109 
                  e+++   e +
  EFC37578.1 3271 EVFQETIETV 3280
                  9987665555 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       3.4   2.4e+03       9      32 ..     382     405 ..     379     437 .. 0.53
   2 ?   -1.9   0.0         6   4.1e+03      15      71 ..     648     662 ..     644     664 .. 0.52
   3 ?    6.0   0.0     0.022        15       8      75 ..     675     734 ..     671     735 .. 0.88
   4 ?    3.7   0.1      0.11        78      23      72 ..     755     802 ..     751     805 .. 0.75
   5 ?   -0.8   0.0       2.7   1.9e+03      10      74 ..     850     872 ..     845     877 .. 0.58
   6 ?   -2.3   0.1       8.1   5.6e+03      10      33 ..     939     962 ..     936     978 .. 0.77
   7 ?   -0.1   0.0       1.6   1.1e+03       8      42 ..     964     996 ..     958    1002 .. 0.85
   8 ?    6.3   0.4     0.017        12      19      72 ..    1116    1172 ..    1110    1176 .. 0.58
   9 ?    2.7   0.0      0.23   1.6e+02       8      32 ..    1184    1208 ..    1177    1209 .. 0.87
  10 ?   -0.4   0.0       2.2   1.5e+03      57      76 ..    1243    1262 ..    1237    1263 .. 0.82
  11 ?    2.9   0.0       0.2   1.3e+02      26      76 ..    1281    1330 ..    1268    1331 .. 0.87
  12 !   12.2   2.3   0.00025      0.17      13      72 ..    1362    1413 ..    1359    1418 .. 0.81
  13 !    8.7   0.1     0.003         2      47      73 ..    1421    1447 ..    1415    1451 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 3.4
      TPR_12   9 laavlrrlgrydeAlellekalei 32 
                 +a+++++l+ +d+A    e+ l +
  EFC37578.1 382 RAECYMKLKMWDKANIDVEEGLKL 405
                 567777777777764444444444 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 6
      TPR_12  15 rlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleea 71 
                 ++                                           + ++A++ll+++
  EFC37578.1 648 EQS------------------------------------------DCDQAIDLLKKV 662
                 444..........................................555555555554 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.022
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaia 75 
                  la++ +   +y ++ ++ +k+le+a  +  +++     +++ +g +y+a  +  +A+e++ + ++ +
  EFC37578.1 675 ALADAFYLKTDYKQCVKYAKKVLEMA--V--DYW----KAYYIIGSCYLAKRKVTKAIEFFGQGVENC 734
                 69999999******************..5..555....699*******9999*******999988876 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.11
      TPR_12  23 lellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72 
                 +  l++al  a++   ++  + a+ l  ++  ++++g+ye+Al   +e++
  EFC37578.1 755 FNQLKQALKDAEKK--KETMQKAANLSIYAKQLFQQGNYEDALLTINEVI 802
                 56677888888888..7788888888888888888888888887766665 PP

  == domain 5  score: -0.8 bits;  conditional E-value: 2.7
      TPR_12  10 aavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                 +++l+ l ry+ +++ le+a++                                          +
  EFC37578.1 850 GVALQFLNRYHHSITVLEAAMR------------------------------------------M 872
                 5555555555555555555554..........................................4 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 8.1
      TPR_12  10 aavlrrlgrydeAlellekaleia 33 
                 a++++    +deA++l+ ++ + +
  EFC37578.1 939 AQIEQIVSLLDEAIDLYPHSADFY 962
                 667777777899999998888776 PP

  == domain 7  score: -0.1 bits;  conditional E-value: 1.6
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhp 42 
                   a + + l +y  + ++ ++a+e++r++  +d +
  EFC37578.1 964 SKARCKYLLRQYIHCVSHIKEAIEVMRQI--TDGL 996
                 579999*********************99..6664 PP

  == domain 8  score: 6.3 bits;  conditional E-value: 0.017
      TPR_12   19 ydeAlellekaleia.rrllGp..dhpltattlrnLgrlyralgryeeAlelleeal 72  
                  + eA++ + +al +  + + ++  d  ++a+ ++  +++y++ +++e+ +e  ++a+
  EFC37578.1 1116 FYEAIRQFTEALSLKiEDSEEKtqDDRDYASLYFERAECYYENEEFEKSIEDCRQAV 1172
                  556666666666665333322211335677777777777777777777766555554 PP

  == domain 9  score: 2.7 bits;  conditional E-value: 0.23
      TPR_12    8 nlaavlrrlgrydeAlellekalei 32  
                   l   l++ g+++e++el++ al++
  EFC37578.1 1184 LLCKSLMETGNLEESIELCNSALAQ 1208
                  57778999**************986 PP

  == domain 10  score: -0.4 bits;  conditional E-value: 2.2
      TPR_12   57 algryeeAlelleealaiae 76  
                  ++++++ A++ l++a+++++
  EFC37578.1 1243 EAEEFDVAINCLNKAIRLRP 1262
                  678999999****9999986 PP

  == domain 11  score: 2.9 bits;  conditional E-value: 0.2
      TPR_12   26 lekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaiae 76  
                  ++kal+  +++l +  p  +++ r  ++++++l+++ eA  ll+  +++++
  EFC37578.1 1281 FKKALDDSTKVL-KFDPKNIIAIRLHSDIHLELKNFSEAKTLLQNGMDMYP 1330
                  677888887776.7888899999********************99999986 PP

  == domain 12  score: 12.2 bits;  conditional E-value: 0.00025
      TPR_12   13 lrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72  
                  +++ g+y++Alel+  a      +  + h++ a++l+  +r++++l ++e Al+  +eal
  EFC37578.1 1362 CYANGNYEQALELYSSA------I--HLHDDCAQYLCRRARVLLKLSQPEIALKDAQEAL 1413
                  56666666666666666......3..557779**************************98 PP

  == domain 13  score: 8.7 bits;  conditional E-value: 0.003
      TPR_12   47 tlrnLgrlyralgryeeAlelleeala 73  
                  ++ +L+++y++l +ye+A e+ ee+l 
  EFC37578.1 1421 VYATLATIYLELCDYEKAKEIIEESLT 1447
                  577888888888888888888888876 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0      0.23   1.6e+02      25      63 ..     372     410 ..     356     414 .. 0.85
   2 ?    3.4   0.0      0.12        84       5      62 ..     819     876 ..     817     881 .. 0.91
   3 ?    2.2   0.0       0.3     2e+02      29      58 ..    1145    1174 ..    1140    1182 .. 0.87
   4 !   10.2   0.0   0.00092      0.64       5      63 ..    1241    1299 ..    1239    1306 .. 0.89
   5 !    7.6   0.0    0.0058         4       5      67 ..    1275    1337 ..    1271    1342 .. 0.93
   6 ?    6.6   0.7     0.013       8.8       9      62 ..    1366    1419 ..    1363    1446 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.23
       TPR_9  25 aPddpeerrdRGlllaqlGclsaAladLeaylalapdap 63 
                 +P+ +e +r R+ ++++l  + +A  d e  l l  d+ 
  EFC37578.1 372 NPKNIEQYRTRAECYMKLKMWDKANIDVEEGLKLRHDDS 410
                 79999******************9999888777666665 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.12
       TPR_9   5 aireedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapda 62 
                 ++ ++++  al+v+ +   + P++ e ++  G++l+ l++++  +  Lea++++ p++
  EFC37578.1 819 LLGKKKHLNALKVAVLASRISPKSYEGYLCQGVALQFLNRYHHSITVLEAAMRMFPEN 876
                 677889999******************************************9988875 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.3
       TPR_9   29 peerrdRGlllaqlGclsaAladLeaylal 58  
                  ++++++R+ ++++ + +++ ++d  +++ l
  EFC37578.1 1145 ASLYFERAECYYENEEFEKSIEDCRQAVKL 1174
                  7899******************98887765 PP

  == domain 4  score: 10.2 bits;  conditional E-value: 0.00092
       TPR_9    5 aireedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdap 63  
                  ai++e++++a+ +++  + l P+ +e ++ R  +l+++  +++Al+d    l  +p++ 
  EFC37578.1 1241 AIEAEEFDVAINCLNKAIRLRPNNIEYLLARSKALFERQKFKKALDDSTKVLKFDPKNI 1299
                  7999*******************************************877777777665 PP

  == domain 5  score: 7.6 bits;  conditional E-value: 0.0058
       TPR_9    5 aireedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaea 67  
                  + +++++ +al  +  +l ++P+ +  +r    ++ +l ++s+A   L+  +++ p++++ ++
  EFC37578.1 1275 LFERQKFKKALDDSTKVLKFDPKNIIAIRLHSDIHLELKNFSEAKTLLQNGMDMYPNDQTLRL 1337
                  57899***************************************************9999775 PP

  == domain 6  score: 6.6 bits;  conditional E-value: 0.013
       TPR_9    9 edweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapda 62  
                   ++e+al+ + + + l+ d ++ +  R+++l +l +++ Al+d + +l ++ + 
  EFC37578.1 1366 GNYEQALELYSSAIHLHDDCAQYLCRRARVLLKLSQPEIALKDAQEALLHDTSE 1419
                  6799***************************************99999888654 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.0   8.1e-07   0.00056      15      44 ..       2      30 ..       1      40 [. 0.90
   2 ?    2.5   0.2      0.28   1.9e+02      18      41 ..     114     132 ..     113     138 .. 0.82
   3 !    8.7   0.0    0.0033       2.2       6      47 ..     219     260 ..     213     263 .. 0.83
   4 ?    0.3   0.0       1.4   9.8e+02       2      21 ..     270     291 ..     269     294 .. 0.75

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 8.1e-07
     Kelch_6 15 YifGGytdsspylnkvwvydpetksWeqlp 44
                ++fGGy++ s++l ++w++d+etk W+q++
  EFC37578.1  2 WVFGGYSG-SEPLADFWCLDLETKIWTQVA 30
                79******.9******************98 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.28
     Kelch_6  18 GGytdsspylnkvwvydpetksWe 41 
                 GG +     +n+vw +++ t +W 
  EFC37578.1 114 GGTC-----FNDVWSFSFTTSKWH 132
                 5555.....5*************5 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0033
     Kelch_6   6 slvsvg.gkiYifGGytdsspylnkvwvydpetksWeqlpplp 47 
                 ++v +g g i ifGG  d  ++ ++ +++d+ + s+ +lp+++
  EFC37578.1 219 AAVNIGrGCILIFGGVRD-YTHRRDCHILDLVNESFVPLPRMI 260
                 333344689*******99.8*********************97 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 1.4
     Kelch_6   2 raghsl..vsvggkiYifGGyt 21 
                 r+gh +   s ++ +Y+ GG++
  EFC37578.1 270 RKGHIMiyDSSDDCVYVNGGSN 291
                 67777733457889******97 PP

>> TPR_15  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0      0.01         7     110     184 ..     339     414 ..     334     434 .. 0.81
   2 !    9.8   0.1    0.0006      0.41     126     180 ..     755     809 ..     746     882 .. 0.91
   3 ?    3.5   0.2     0.051        35     118     181 ..    1072    1135 ..    1058    1140 .. 0.90
   4 ?   -1.2   0.0       1.3     9e+02     147     203 ..    1266    1322 ..    1251    1338 .. 0.73
   5 !   12.2   0.3   0.00011     0.079     144     205 ..    1384    1444 ..    1351    1457 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.01
      TPR_15 110 prlLssalellerakdydriaellksleeeeaae.qsaafllaraelyrqegqtdaAlrdyreAlalapdsselra 184
                  ++L++ +++ + +++ +++++l++  + + + + ++   +  rae y +   +d+A  d++e+l+l  d+s+++ 
  EFC37578.1 339 EKHLYEDVKVDKTQEEKNQLVKLIEAETIKIRKNpKNIEQYRTRAECYMKLKMWDKANIDVEEGLKLRHDDSDFKT 414
                 5788888888889999999999999966555544466677899*****************************9874 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.0006
      TPR_15 126 ydriaellksleeeeaaeqsaafllaraelyrqegqtdaAlrdyreAlalapdss 180
                 ++++++ lk +e++++  q aa l+++a+   q+g+ ++Al  + e+++++p++ 
  EFC37578.1 755 FNQLKQALKDAEKKKETMQKAANLSIYAKQLFQQGNYEDALLTINEVIEKDPTNI 809
                 6899************************************************975 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.051
      TPR_15  118 ellerakdydriaellksleeeeaaeqsaafllaraelyrqegqtdaAlrdyreAlalapdsse 181 
                  +l+ +++ ++++++l k++e +++ ++   fl+  +   + +++  +A+r++ eAl+l+ ++se
  EFC37578.1 1072 HLYLQSEHIEKLEDLTKKVEDLKRTRDKFDFLVKAGMKSKSKNDFYEAIRQFTEALSLKIEDSE 1135
                  57789999**************************99999*******************999886 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 1.3
      TPR_15  147 afllaraelyrqegqtdaAlrdyreAlalapdsselraallWlliDlgrraeLrell 203 
                   +llar+++  ++ + ++Al d  ++l+ +p++  ++  +  + ++l++  e++ ll
  EFC37578.1 1266 EYLLARSKALFERQKFKKALDDSTKVLKFDPKNIIAIRLHSDIHLELKNFSEAKTLL 1322
                  589999999999999999999999999999986544444444444555555555555 PP

  == domain 5  score: 12.2 bits;  conditional E-value: 0.00011
      TPR_15  144 qsaafllaraelyrqegqtdaAlrdyreAlalapdsselraallWlliDlgrraeLrellka 205 
                  + a++l +ra++ ++ +q++ Al+d++eAl   ++s+e+ a+l  ++++l  +++++e++++
  EFC37578.1 1384 DCAQYLCRRARVLLKLSQPEIALKDAQEALLH-DTSEEVYATLATIYLELCDYEKAKEIIEE 1444
                  5589**************************65.5669******9999999999999999865 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0       1.2     8e+02      11      32 ..     648     667 ..     647     671 .. 0.78
   2 ?    3.6   0.0      0.12        82       1      27 [.     706     730 ..     706     743 .. 0.91
   3 ?    0.4   0.0       1.2   8.3e+02      10      34 ..     786     808 ..     782     810 .. 0.83
   4 ?   -0.3   0.0       2.1   1.5e+03       6      29 ..     850     871 ..     849     884 .. 0.82
   5 ?   -2.3   0.0         9   6.2e+03      13      30 ..    1114    1131 ..    1112    1137 .. 0.68
   6 ?   -0.6   0.1       2.7   1.8e+03       4      28 ..    1150    1172 ..    1147    1178 .. 0.79
   7 ?   -1.3   0.0       4.4     3e+03      11      33 ..    1191    1211 ..    1187    1212 .. 0.85
   8 ?   -2.3   0.0       9.2   6.3e+03      14      35 ..    1246    1265 ..    1243    1266 .. 0.85
   9 ?    4.2   0.2     0.074        51      12      30 ..    1365    1383 ..    1359    1387 .. 0.77
  10 !   12.6   0.2   0.00015      0.11       2      31 ..    1422    1451 ..    1421    1462 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 1.2
       TPR_7  11 rlGdyeeAielyeqsLaltkdp 32 
                 ++ d ++Ai+l+++  ++  +p
  EFC37578.1 648 EQSDCDQAIDLLKK--VISFEP 667
                 6899*********9..665555 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.12
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLa 27 
                 a++ ++++y + ++  +Aie++ q  +
  EFC37578.1 706 AYYIIGSCYLAKRKVTKAIEFFGQ--G 730
                 68889*****************99..5 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 1.2
       TPR_7  10 srlGdyeeAielyeqsLaltkdped 34 
                 +++G+ye+A+    +  +++kdp++
  EFC37578.1 786 FQQGNYEDALLTINE--VIEKDPTN 808
                 689******988888..88888876 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 2.1
       TPR_7   6 arlysrlGdyeeAielyeqsLalt 29 
                 +++ + l++y   i+++e+  a++
  EFC37578.1 850 GVALQFLNRYHHSITVLEA--AMR 871
                 6778889************..655 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 9
       TPR_7   13 GdyeeAielyeqsLaltk 30  
                  +d+ eAi+ ++++L l  
  EFC37578.1 1114 NDFYEAIRQFTEALSLKI 1131
                  677799999999665553 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 2.7
       TPR_7    4 nLarlysrlGdyeeAielyeqsLal 28  
                    a++y +  ++e+ ie ++q  a+
  EFC37578.1 1150 ERAECYYENEEFEKSIEDCRQ--AV 1172
                  5688999999********999..44 PP

  == domain 7  score: -1.3 bits;  conditional E-value: 4.4
       TPR_7   11 rlGdyeeAielyeqsLaltkdpe 33  
                  + G+ ee iel+    al+ +p+
  EFC37578.1 1191 ETGNLEESIELCNS--ALAQSPF 1211
                  789*********99..8888876 PP

  == domain 8  score: -2.3 bits;  conditional E-value: 9.2
       TPR_7   14 dyeeAielyeqsLaltkdpeda 35  
                  +++ Ai ++ +  a++ +p+++
  EFC37578.1 1246 EFDVAINCLNK--AIRLRPNNI 1265
                  7999*******..999999876 PP

  == domain 9  score: 4.2 bits;  conditional E-value: 0.074
       TPR_7   12 lGdyeeAielyeqsLaltk 30  
                   G+ye+A+ely  ++ l++
  EFC37578.1 1365 NGNYEQALELYSSAIHLHD 1383
                  49*********99655555 PP

  == domain 10  score: 12.6 bits;  conditional E-value: 0.00015
       TPR_7    2 LlnLarlysrlGdyeeAielyeqsLaltkd 31  
                  +  La +y +l dye+A e+ e+sL ++++
  EFC37578.1 1422 YATLATIYLELCDYEKAKEIIEESLTFDDE 1451
                  6779*******************8888765 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.1   1.4e-06   0.00095      16      44 ..       2      29 ..       1      38 [. 0.89
   2 !   10.1   0.3   0.00091      0.63      25      47 ..     115     137 ..     109     140 .. 0.86
   3 ?    1.1   0.0      0.58     4e+02       2      22 ..     215     235 ..     215     257 .. 0.77
   4 ?   -1.4   0.0       3.5   2.4e+03       1      24 [.     269     293 ..     269     297 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 1.4e-06
     Kelch_4 16 ylfGGrgedgtllndlylldlstntWrrl 44
                ++fGG+++  ++l+d + ldl+t+ W+++
  EFC37578.1  2 WVFGGYSGS-EPLADFWCLDLETKIWTQV 29
                89******9.9*****************9 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00091
     Kelch_4  25 gtllndlylldlstntWrrlgsl 47 
                 gt++nd++ ++++t +W  l+++
  EFC37578.1 115 GTCFNDVWSFSFTTSKWHCLTDP 137
                 59***************999655 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.58
     Kelch_4   2 RaghsatsipdgtiylfGGrg 22 
                 R + +a+ i++g i +fGG  
  EFC37578.1 215 RYSSAAVNIGRGCILIFGGVR 235
                 677899*************55 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 3.5
     Kelch_4   1 pRaghsatsi.pdgtiylfGGrged 24 
                 +R gh ++++  d+ +y+ GG + +
  EFC37578.1 269 ARKGHIMIYDsSDDCVYVNGGSNFK 293
                 7999999***77799******9987 PP

>> DUF627  Protein of unknown function (DUF627)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.1   0.00075      0.51      61     106 ..     654     699 ..     634     701 .. 0.88
   2 ?    5.5   0.0     0.024        17       2      27 ..     782     807 ..     781     852 .. 0.91
   3 ?    3.0   0.1      0.15     1e+02      62     107 ..    1119    1175 ..    1103    1176 .. 0.85
   4 ?   -2.9   0.0       9.6   6.7e+03      62     105 ..    1250    1293 ..    1246    1295 .. 0.86
   5 !    8.2   0.0    0.0036       2.5       1      46 [.    1358    1400 ..    1358    1412 .. 0.89
   6 ?   -2.3   0.0       6.3   4.3e+03       8      27 ..    1450    1469 ..    1427    1487 .. 0.50
   7 ?   -2.3   0.0       6.6   4.5e+03      10      28 ..    3114    3132 ..    3112    3155 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00075
      DUF627  61 asvecfseavelsrfyArsLfelasqlgsklyYkkavkkakraLsv 106
                  +++ +++  ++  f  + ++ la+ +  k +Yk++vk ak+ L +
  EFC37578.1 654 QAIDLLKKVISFEPFGVKYIIALADAFYLKTDYKQCVKYAKKVLEM 699
                 68888999999999****************************9975 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.024
      DUF627   2 AkdllargnhikALeiiedlisrhge 27 
                 Ak+l+++gn+ +AL  i+++i +   
  EFC37578.1 782 AKQLFQQGNYEDALLTINEVIEKDPT 807
                 89*******************87655 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.15
      DUF627   62 svecfseavels...........rfyArsLfelasqlgsklyYkkavkkakraLsve 107 
                  ++  f+ea +l+           r yA++ fe a+ +  + +++k+++ +++a+++e
  EFC37578.1 1119 AIRQFTEALSLKiedseektqddRDYASLYFERAECYYENEEFEKSIEDCRQAVKLE 1175
                  6667777777777778888888899***************************98765 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 9.6
      DUF627   62 svecfseavelsrfyArsLfelasqlgsklyYkkavkkakraLs 105 
                  +++c+++a +l     + L+   + l  ++++kka+  + + L+
  EFC37578.1 1250 AINCLNKAIRLRPNNIEYLLARSKALFERQKFKKALDDSTKVLK 1293
                  78999999999999999999999999999999999999888886 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.0036
      DUF627    1 kAkdllargnhikALeiiedlisrhgedeksallhrlqGtifvkla 46  
                  +A+d++a+gn+ +ALe+   +i  h +   +a+    ++ +++kl+
  EFC37578.1 1358 DAEDCYANGNYEQALELYSSAIHLHDD---CAQYLCRRARVLLKLS 1400
                  599*******************99999...8888888888888876 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 6.3
      DUF627    8 rgnhikALeiiedlisrhge 27  
                  + + ++ L +++d i ++++
  EFC37578.1 1450 DEEAMDNLLLLKDEIYDRES 1469
                  23333334445555544444 PP

  == domain 7  score: -2.3 bits;  conditional E-value: 6.6
      DUF627   10 nhikALeiiedlisrhged 28  
                  ++ kA+e+i+ +i ++ ++
  EFC37578.1 3114 DREKAFEVIQTFILKNASE 3132
                  889**********998875 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.0     0.002       1.4      17      41 ..       1      23 [.       1      24 [. 0.92
   2 ?    0.1   0.0       1.2   8.3e+02       2      12 ..      37      47 ..      36      63 .. 0.73
   3 ?    2.4   0.0      0.23   1.6e+02       2      23 ..     212     234 ..     211     242 .. 0.83
   4 ?    3.3   0.0      0.12        83       1      24 [.     266     291 ..     266     301 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.002
     Kelch_5 17 iYvyGGkvgrdgsvsddvyvLdlps 41
                ++v+GG++g  +++  d++ Ldl++
  EFC37578.1  1 MWVFGGYSG--SEPLADFWCLDLET 23
                68******6..************97 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 1.2
     Kelch_5  2 PppRaghcavt 12
                P++R+gh+ v+
  EFC37578.1 37 PEARYGHSGVI 47
                9*******995 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.23
     Kelch_5   2 PppRaghcavtvs.ekiYvyGGk 23 
                 P  R++++av  + + i+++GG+
  EFC37578.1 212 PDERYSSAAVNIGrGCILIFGGV 234
                 77888888887767********8 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.12
     Kelch_5   1 iPppRaghcavtvs..ekiYvyGGkv 24 
                 +P++R gh ++++s  + +Yv GG +
  EFC37578.1 266 WPTARKGHIMIYDSsdDCVYVNGGSN 291
                 7************76799******87 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       3.9   2.7e+03       7      19 ..     383     395 ..     382     396 .. 0.92
   2 ?   -0.2   0.0         3   2.1e+03      13      28 ..     649     664 ..     639     667 .. 0.84
   3 ?    0.6   0.2       1.6   1.1e+03       6      28 ..     676     698 ..     675     698 .. 0.89
   4 ?    6.1   0.0     0.028        19       2      24 ..     706     728 ..     705     729 .. 0.90
   5 ?    3.6   0.0      0.18   1.3e+02       8      32 ..     783     807 ..     780     808 .. 0.86
   6 ?   -0.2   0.0       2.9     2e+03      15      33 .]     940     958 ..     935     958 .. 0.88
   7 ?    2.8   0.0      0.32   2.2e+02       3      28 ..    1148    1173 ..    1146    1175 .. 0.84
   8 ?   -1.4   0.0       7.1   4.9e+03      10      31 ..    1309    1330 ..    1306    1332 .. 0.78
   9 ?    4.1   0.1      0.13        87       9      28 ..    1362    1380 ..    1351    1384 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 3.9
                 HHHHHHHHHHHHH CS
       TPR_6   7 alsyrklgdtdkA 19 
                 a++y kl+ +dkA
  EFC37578.1 383 AECYMKLKMWDKA 395
                 99****99****9 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 3
                 HHHHHHHHHHHHHHHH CS
       TPR_6  13 lgdtdkAlealerlik 28 
                 + d d+A+++l+++i+
  EFC37578.1 649 QSDCDQAIDLLKKVIS 664
                 55889*********96 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 1.6
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAlealerlik 28 
                 la +++  +d+ + +++ +++++
  EFC37578.1 676 LADAFYLKTDYKQCVKYAKKVLE 698
                 789999978**********9985 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.028
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAleale 24 
                 A+y ++ +y++  + +kA+e + 
  EFC37578.1 706 AYYIIGSCYLAKRKVTKAIEFFG 728
                 9*********977*******996 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.18
                 HHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   8 lsyrklgdtdkAlealerlikeYPd 32 
                 + ++++g++++Al + +++i++ P+
  EFC37578.1 783 KQLFQQGNYEDALLTINEVIEKDPT 807
                 5567889***************996 PP

  == domain 6  score: -0.2 bits;  conditional E-value: 2.9
                 HHHHHHHHHHHHHHH-TT- CS
       TPR_6  15 dtdkAlealerlikeYPdS 33 
                 + ++ + +l++ i+ YP S
  EFC37578.1 940 QIEQIVSLLDEAIDLYPHS 958
                 6788999**********98 PP

  == domain 7  score: 2.8 bits;  conditional E-value: 0.32
                  HHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6    3 lyklalsyrklgdtdkAlealerlik 28  
                  ++ +a++y++  + +k++e  ++ +k
  EFC37578.1 1148 YFERAECYYENEEFEKSIEDCRQAVK 1173
                  6999******66**999998887765 PP

  == domain 8  score: -1.4 bits;  conditional E-value: 7.1
                  HHHHHHHHHHHHHHHHHHHH-T CS
       TPR_6   10 yrklgdtdkAlealerlikeYP 31  
                  +++l++ ++A+++l++  + YP
  EFC37578.1 1309 HLELKNFSEAKTLLQNGMDMYP 1330
                  67889*********97555555 PP

  == domain 9  score: 4.1 bits;  conditional E-value: 0.13
                  HHHHHHHHHHHHHHHHHHHH CS
       TPR_6    9 syrklgdtdkAlealerlik 28  
                  +y ++ ++++Ale++ + i 
  EFC37578.1 1362 CYANG-NYEQALELYSSAIH 1380
                  66666.*********99886 PP

>> TPR_MalT  MalT-like TPR region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.3   9.1e+02      56     105 ..     751     800 ..     686     804 .. 0.67
   2 !    8.9   0.0    0.0012      0.85      85     189 ..    1105    1207 ..    1079    1256 .. 0.81
   3 ?    3.9   3.6     0.041        28     124     265 ..    1301    1444 ..    1292    1454 .. 0.57

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.3
    TPR_MalT  56 leaAlqalqeaeklarqadslhvallallqqaeilvaqGrLheAletyeq 105
                 ++++ ++l++a k a + + + + +  l   a++l++qG  ++Al t ++
  EFC37578.1 751 VNEGFNQLKQALKDAEKKKETMQKAANLSIYAKQLFQQGNYEDALLTINE 800
                 44555556666666655555555555555566666666666666666655 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0012
    TPR_MalT   85 qqaeilvaqGrLheAletyeqalqlateqglqql...plvgfllvlladllyEwndLeeAeqhlqeGielleqlepeaaldayvllarialaqGdle 178 
                  + ++    ++++ eA++ +++al l  e +++++   + +  l+ ++a+ +yE  ++e+  + ++++++l   +      + yvll++  +  G+le
  EFC37578.1 1105 KAGMKSKSKNDFYEAIRQFTEALSLKIEDSEEKTqddRDYASLYFERAECYYENEEFEKSIEDCRQAVKLESTF-----PHFYVLLCKSLMETGNLE 1196
                  56666677899**************9988888873334667778888888888888888888888887776655.....799*************** PP

    TPR_MalT  179 eAetllekaee 189 
                  e+ +l++ a +
  EFC37578.1 1197 ESIELCNSALA 1207
                  ****9998865 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.041
    TPR_MalT  124 llvlladllyEwndLeeAeqhlqeGielleql.......epeaaldayvllarialaqGdleeAetllekaeelaresnfhvdwla...naeevrvr 210 
                  + +l +d+++E  ++ eA++ lq+G+++           e+ ++++++   a +++   +   A    e+a el+  s +h+ +++     +++rv+
  EFC37578.1 1301 AIRLHSDIHLELKNFSEAKTLLQNGMDMYPNDqtlrlrlEKLIRIESQWNEAYLRARDAEDCYANGNYEQALELYS-SAIHLHDDCaqyLCRRARVL 1396
                  568899*******************876433200000113333334444444444333333344444556666665.44444333311233444444 PP

    TPR_MalT  211 lwlaqgdlaaaerwleaaelpsdddnhflelelrnlarvllalgrydeAleller 265 
                  l     + + a++ +++a l + + +++      +la ++l+l +y++A+e++e+
  EFC37578.1 1397 L--KLSQPEIALKDAQEALLHDTSEEVY-----ATLATIYLELCDYEKAKEIIEE 1444
                  3..3333333444444444444444444.....4699999999999999999876 PP

>> Membr_traf_MHD  Munc13 (mammalian uncoordinated) homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.1   1.2e-05     0.008       3      49 ..    2638    2684 ..    2636    2688 .. 0.92
   2 !    7.6   0.0    0.0058         4      92     129 ..    2688    2724 ..    2684    2744 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.2e-05
  Membr_traf_MHD    3 lrPLmdyLdsnLsilaqalektvLkrvlkelWkvvlnalekllLPpl 49  
                      + PL+dyLd +L+ l ++l++ v++ vl ++ ++ +  l++   Pp 
      EFC37578.1 2638 MTPLFDYLDDQLATLYSVLNDRVFEVVLRNIFNMLIDELKECAIPPA 2684
                      78***********************************9999888876 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0058
  Membr_traf_MHD   92 sLtpkevevleaaLdtlkdfFhagGeGlkkeaLkseel 129 
                      +Lt  ++e  + + +   d+F a+G+Gl  +++k  ++
      EFC37578.1 2688 TLTRSQIEKFKTTFESFMDYFNANGSGLDVKYIKE-HF 2724
                      79*****************************9974.34 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.54   3.7e+02       6      32 ..     369     395 ..     369     395 .. 0.92
   2 ?   -1.9   0.0       8.9   6.2e+03       3      33 ..     694     724 ..     692     725 .. 0.78
   3 ?   -1.4   0.0       5.8     4e+03       3      12 ..     799     808 ..     797     814 .. 0.84
   4 ?    3.1   0.1      0.22   1.5e+02       2      24 ..     948     970 ..     947     977 .. 0.84
   5 ?    4.8   0.0     0.063        43      11      33 ..    1143    1165 ..    1138    1166 .. 0.85
   6 ?    4.5   0.2     0.076        53       1      33 [.    1253    1285 ..    1253    1286 .. 0.92
   7 ?   -1.9   0.1       8.5   5.9e+03       2      32 ..    1368    1405 ..    1364    1407 .. 0.60
   8 ?    1.4   0.0      0.75   5.2e+02      13      34 .]    1419    1440 ..    1409    1440 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.54
      TPR_17   6 leldPnnadaynnLAelllknGdlmtA 32 
                 ++++P+n + y  +Ae++ k++ +++A
  EFC37578.1 369 IRKNPKNIEQYRTRAECYMKLKMWDKA 395
                 789*****************9998887 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 8.9
      TPR_17   3 lkaleldPnnadaynnLAelllknGdlmtAr 33 
                 +k+le   ++++ay+  + ++l + +  +A+
  EFC37578.1 694 KKVLEMAVDYWKAYYIIGSCYLAKRKVTKAI 724
                 566666678999*********9887777776 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 5.8
      TPR_17   3 lkaleldPnn 12 
                  +++e+dP+n
  EFC37578.1 799 NEVIEKDPTN 808
                 579******9 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.22
      TPR_17   2 ylkaleldPnnadaynnLAelll 24 
                 + +a++l+P +ad+y  +A++ +
  EFC37578.1 948 LDEAIDLYPHSADFYLSKARCKY 970
                 679****************9855 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.063
      TPR_17   11 nnadaynnLAelllknGdlmtAr 33  
                  ++a +y+++Ae++++n ++++ +
  EFC37578.1 1143 DYASLYFERAECYYENEEFEKSI 1165
                  7899************9988765 PP

  == domain 6  score: 4.5 bits;  conditional E-value: 0.076
      TPR_17    1 lylkaleldPnnadaynnLAelllknGdlmtAr 33  
                  ++ ka++l Pnn + +  + ++l ++ ++++A+
  EFC37578.1 1253 CLNKAIRLRPNNIEYLLARSKALFERQKFKKAL 1285
                  678********************9999999986 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 8.5
      TPR_17    2 ylkaleld......Pnn.adaynnLAelllknGdlmtA 32  
                  y++alel+      +++ a  ++ +A++llk+ +++ A
  EFC37578.1 1368 YEQALELYssaihlHDDcAQYLCRRARVLLKLSQPEIA 1405
                  55555555222222233567778888888888887655 PP

  == domain 8  score: 1.4 bits;  conditional E-value: 0.75
      TPR_17   13 adaynnLAelllknGdlmtArq 34  
                   ++y  LA+++l++ d+++A++
  EFC37578.1 1419 EEVYATLATIYLELCDYEKAKE 1440
                  589*********9999999975 PP

>> Alkyl_sulf_dimr  Alkyl sulfatase dimerisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.3     0.028        20      58     113 ..     764     819 ..     755     837 .. 0.82
   2 ?   -2.3   0.0       8.2   5.7e+03      77     106 ..    1187    1216 ..    1182    1247 .. 0.74
   3 ?    2.2   0.1      0.33   2.3e+02      68     107 ..    1230    1269 ..    1208    1321 .. 0.68
   4 ?    0.9   0.2      0.85   5.9e+02      75     119 ..    1358    1402 ..    1352    1416 .. 0.86
   5 ?    1.4   0.0      0.59   4.1e+02      66     108 ..    1526    1568 ..    1512    1582 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.028
                      HHHHHHHHTTSHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHHHHHHHH CS
  Alkyl_sulf_dimr  58 kakrlvelmGgaekvlekakealkegdyrwaaellnhlvfadpenaeakelkadal 113
                       a++  e m  a+++   ak+ +++g+y+ a+  +n ++++dp+n +  + k+d+l
       EFC37578.1 764 DAEKKKETMQKAANLSIYAKQLFQQGNYEDALLTINEVIEKDPTNISYLSDKVDIL 819
                      577778899999999*****************************966555555544 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 8.2
                       HHHHHTT-HHHHHHHHHHHHHHSTT-HHHH CS
  Alkyl_sulf_dimr   77 kealkegdyrwaaellnhlvfadpenaeak 106 
                       k+ ++ g+++ ++el+n ++++ p n+   
       EFC37578.1 1187 KSLMETGNLEESIELCNSALAQSPFNTPLN 1216
                       6788999*************9988874333 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.33
                       SHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHH CS
  Alkyl_sulf_dimr   68 gaekvlekakealkegdyrwaaellnhlvfadpenaeake 107 
                       +aek  e+ +ea++++++ +a++ ln+++   p+n e   
       EFC37578.1 1230 DAEKKFEEGREAIEAEEFDVAINCLNKAIRLRPNNIEYLL 1269
                       6677777888888888888888888888888877733322 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.85
                       HHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHHHHHHHHHHHHHH CS
  Alkyl_sulf_dimr   75 kakealkegdyrwaaellnhlvfadpenaeakelkadaleqlgyq 119 
                        a++ +++g+y+ a+el + ++  +++ a+    +a++l +l++ 
       EFC37578.1 1358 DAEDCYANGNYEQALELYSSAIHLHDDCAQYLCRRARVLLKLSQP 1402
                       688999*****************9999888888888888888765 PP

  == domain 5  score: 1.4 bits;  conditional E-value: 0.59
                       TTSHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHHH CS
  Alkyl_sulf_dimr   66 mGgaekvlekakealkegdyrwaaellnhlvfadpenaeakel 108 
                        Gg+++ +e  +e+ + +d++ a+el + +v  +p+n++  + 
       EFC37578.1 1526 YGGKKEKIEIEEEDDSYEDLQKAQELFSEAVLLEPNNKRYLRH 1568
                       68888889999999999*******************9865544 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.2     0.021        15      16      45 ..       3      29 ..       2      30 .. 0.94
   2 ?    3.2   0.4      0.14        99      28      48 ..     117     137 ..     111     138 .. 0.88
   3 ?    6.1   0.1     0.017        12       2      30 ..     215     246 ..     214     250 .. 0.78
   4 ?   -1.8   0.1       5.4   3.7e+03       6      25 ..     276     292 ..     273     294 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.021
     Kelch_2 16 vvGGahtdnpnlsssdvhvldlekhvWeev 45
                v+GG+    +++   d+++ldle++ W+ v
  EFC37578.1  3 VFGGY---SGSEPLADFWCLDLETKIWTQV 29
                89***...*******************987 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.14
     Kelch_2  28 sssdvhvldlekhvWeevtpl 48 
                  ++dv+ + + + +W ++t++
  EFC37578.1 117 CFNDVWSFSFTTSKWHCLTDP 137
                 599***************986 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.017
     Kelch_2   2 rgghsssvp.ggkiyvvGGa..htdnpnlsss 30 
                 r+ ++++ + +g+i+++GG+  +t+  ++ + 
  EFC37578.1 215 RYSSAAVNIgRGCILIFGGVrdYTHRRDCHIL 246
                 6777777545**********999998877555 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 5.4
     Kelch_2   6 sssvpggkiyvvGGahtdnp 25 
                 ++ ++++++yv GG+   n+
  EFC37578.1 276 IYDSSDDCVYVNGGS---NF 292
                 567899********9...66 PP

>> TPR_20  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.2      0.02        14      28      53 ..     781     806 ..     753     811 .. 0.72
   2 ?    0.1   0.0       1.5     1e+03       6      45 ..    1129    1168 ..    1124    1178 .. 0.85
   3 ?    4.3   0.1     0.074        51      10      53 ..    1253    1296 ..    1247    1335 .. 0.89
   4 ?   -1.6   0.1       5.3   3.6e+03      24      44 ..    1354    1374 ..    1343    1387 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.02
      TPR_20  28 lAlallaagryeeAleqLleilkrdr 53 
                 +A++l+++g+ye+Al  + e++++d 
  EFC37578.1 781 YAKQLFQQGNYEDALLTINEVIEKDP 806
                 589*****************999985 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 1.5
      TPR_20    6 pelaeleaalaanpddldarldlAlallaagryeeAleqL 45  
                   ++++ e++ +++ d   + ++ A+ ++++++ e+++e  
  EFC37578.1 1129 LKIEDSEEKTQDDRDYASLYFERAECYYENEEFEKSIEDC 1168
                  57889999999999999******************99865 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.074
      TPR_20   10 eleaalaanpddldarldlAlallaagryeeAleqLleilkrdr 53  
                   l +a+  +p++++  l+ ++al+++++ ++Al+   ++lk d 
  EFC37578.1 1253 CLNKAIRLRPNNIEYLLARSKALFERQKFKKALDDSTKVLKFDP 1296
                  57889999**************************9999998886 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 5.3
      TPR_20   24 arldlAlallaagryeeAleq 44  
                  +r   A+  +a+g+ye+Ale+
  EFC37578.1 1354 LRARDAEDCYANGNYEQALEL 1374
                  566678999**********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (3323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2542  (0.141781); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        36  (0.00200792); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              26  [number of targets reported over threshold]
# CPU time: 1.80u 0.32s 00:00:02.12 Elapsed: 00:00:00.63
# Mc/sec: 15998.59
//
Query:       EFC37579.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-10   39.0   0.0    5.6e-09   36.1   0.0    2.1  2  Kelch_3   Galactose oxidase, central domain
    2.1e-08   33.6   1.2    3.8e-08   32.8   1.2    1.4  1  Kelch_1   Kelch motif
    5.5e-07   29.3   0.4    1.1e-06   28.3   0.4    1.5  1  Kelch_2   Kelch motif
      3e-06   27.1   0.1    5.4e-06   26.3   0.1    1.4  1  Kelch_4   Galactose oxidase, central domain
    5.3e-06   26.5   0.1    2.4e-05   24.5   0.1    2.1  2  Kelch_6   Kelch motif
    5.5e-06   26.2   0.8    8.6e-06   25.6   0.8    1.5  1  Kelch_5   Kelch motif


Domain annotation for each model (and alignments):
>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.22   6.4e+02      24      47 ..      26      52 ..      12      53 .. 0.72
   2 !   36.1   0.0   1.9e-12   5.6e-09       3      46 ..      75     121 ..      73     123 .] 0.90

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.22
     Kelch_3 24 ydl..dtntWaei.aslppaRaghaat 47
                + l  ++n+ +++ ++ p+ R g +++
  EFC37579.1 26 FGLgkNNNNLTTSgPQFPSSREGQTTA 52
                455335568888878889998777765 PP

  == domain 2  score: 36.1 bits;  conditional E-value: 1.9e-12
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydldtntWaei.....aslppaRaghaa 46 
                  + +fGG++  g ++lndv+v+d+  ++W+++      s p++R+ h+a
  EFC37579.1  75 QVILFGGYN--GSNYLNDVWVLDTTEWKWTRCdidekQSRPMGRSMHTA 121
                 5789*****..*******************999977677799*****97 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.8   1.2   1.3e-11   3.8e-08      10      42 ..      72     104 ..      71     105 .. 0.93

  Alignments for each domain:
  == domain 1  score: 32.8 bits;  conditional E-value: 1.3e-11
                 ETTEEEEEEEBCSSSBEEEEEEEETTTTEEEEE CS
     Kelch_1  10 vggkiYviGGsdggnalssvevyDpetntWrel 42 
                 + +++  +GG++g+n+l++v+v+D+++ +W+++
  EFC37579.1  72 MEEQVILFGGYNGSNYLNDVWVLDTTEWKWTRC 104
                 6788999***********************986 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.4   3.7e-10   1.1e-06      10      45 ..      72     104 ..      69     108 .. 0.92

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 3.7e-10
     Kelch_2  10 pggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 ++ +++++GG+   n++ + +dv+vld+ +++W+++
  EFC37579.1  72 MEEQVILFGGY---NGSNYLNDVWVLDTTEWKWTRC 104
                 57899******...********************86 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.1   1.8e-09   5.4e-06      15      44 ..      76     104 ..      72     114 .. 0.88

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 1.8e-09
     Kelch_4  15 iylfGGrgedgtllndlylldlstntWrrl 44 
                 ++lfGG+++    lnd+++ld++  +W+r+
  EFC37579.1  76 VILFGGYNGS-NYLNDVWVLDTTEWKWTRC 104
                 89*******9.7***************997 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.97   2.9e+03      30      38 ..      58      66 ..      49      67 .. 0.78
   2 !   24.5   0.1   7.9e-09   2.4e-05      11      43 ..      73     104 ..      70     114 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.97
     Kelch_6 30 vwvydpetk 38
                v++++p+tk
  EFC37579.1 58 VLKINPITK 66
                678888886 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 7.9e-09
     Kelch_6  11 ggkiYifGGytdsspylnkvwvydpetksWeql 43 
                  +++ +fGGy++ s+yln+vwv+d   ++W+++
  EFC37579.1  73 EEQVILFGGYNG-SNYLNDVWVLDTTEWKWTRC 104
                 67899*******.9****************986 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.8   2.9e-09   8.6e-06      14      41 ..      73      98 ..      42      99 .. 0.84

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 2.9e-09
     Kelch_5 14 sekiYvyGGkvgrdgsvsddvyvLdlps 41
                +e+++++GG++g  +++ +dv+vLd+++
  EFC37579.1 73 EEQVILFGGYNG--SNYLNDVWVLDTTE 98
                478********6..***********975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       323  (0.0180155); expected 358.6 (0.02)
Passed bias filter:                      251  (0.0139997); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.50u 0.36s 00:00:00.86 Elapsed: 00:00:00.55
# Mc/sec: 673.63
//
Query:       EFC37580.1  [L=340]
Description: Hypothetical protein NAEGRDRAFT_74787 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      0.001   18.9   0.4     0.0026   17.6   0.4    1.7  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.022   14.6   0.2      0.092   12.7   0.2    2.0  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.4   2.9e-07    0.0026       6      46 ..      15      55 ..      15      57 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 2.9e-07
  F-box-like  6 dEiLlqIFsyLppsdLlr.lalVCrrWrrvaldtplLWrrlv 46
                d+iLl +F++L+ s  l  ++l+C++ + +++ + + ++rlv
  EFC37580.1 15 DDILLNVFEFLERSYVLDtISLTCKYLNKLCHQP-YNYNRLV 55
                79*********999666659***********776.9999986 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2     1e-05     0.092       6      40 ..      13      48 ..      10      54 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1e-05
                S-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTH CS
       F-box  6 LPsevlrhILerLplsd.llalrrVSkgwrilidsd 40
                L +++l++++e+L+ s+ l  +++++k +++l+  +
  EFC37580.1 13 LIDDILLNVFEFLERSYvLDTISLTCKYLNKLCHQP 48
                5589*************999***********99766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       797  (0.0444531); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 2009.59
//
Query:       EFC37581.1  [L=470]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.9e-30  106.2   1.7    2.4e-30  105.8   0.1    2.0  3  ABC_tran     ABC transporter
    1.4e-12   48.1   8.6    1.5e-08   34.8   0.1    2.7  3  AAA_21       AAA domain, putative AbiEii toxin, Type IV TA sy
    2.1e-08   33.9   3.1    8.8e-07   28.6   1.0    2.6  1  SMC_N        RecF/RecN/SMC N terminal domain
    0.00045   19.9   0.0     0.0009   18.9   0.0    1.5  1  AAA_29       P-loop containing region of AAA domain
     0.0015   18.5   0.7     0.0056   16.6   0.1    2.3  1  ATPase_2     ATPase domain predominantly from Archaea
     0.0022   18.0   0.0      0.014   15.4   0.0    2.3  2  AAA_5        AAA domain (dynein-related subfamily)
     0.0028   17.6   0.3     0.0079   16.1   0.2    1.9  2  RsgA_GTPase  RsgA GTPase
     0.0076   15.5   0.1      0.021   14.0   0.1    1.7  1  NB-ARC       NB-ARC domain
  ------ inclusion threshold ------
       0.01   16.3   1.7      0.082   13.3   0.2    2.8  2  AAA          ATPase family associated with various cellular a
      0.052   13.5   0.4        8.3    6.3   0.0    2.4  2  NTPase_1     NTPase
        3.7    8.0  17.5      0.082   13.4   5.3    2.8  2  AAA_23       AAA domain


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       3.2   5.2e+03      72      95 ..     111     139 ..      92     149 .. 0.50
   2 !  105.8   0.1   1.5e-33   2.4e-30       1     135 [.     160     310 ..     160     312 .. 0.97
   3 ?   -3.5   0.0       8.7   1.4e+04      64      78 ..     426     440 ..     422     462 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 3.2
                 TTSBHHHH.....HHHTCHHHHHHHSTTG CS
                 xxxxxxxx.....xxxxxxxxxxxxxxxx RF
    ABC_tran  72 peltvren.....esdeeiekalsklglk 95 
                 +++t +e+     e + +iek+ ++++ +
  EFC37581.1 111 KNITQQEQhvnnsELNIKIEKITKTFKKD 139
                 22322222333334444566666655544 PP

  == domain 2  score: 105.8 bits;  conditional E-value: 1.5e-33
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................... RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.................... 79 
                 l++++l++k+ge++ ++G+nG+GKStL++l+ gllkp+ G+i +++ ++++ ++   r+++g++pq++ +f++l+v ++                    
  EFC37581.1 160 LNELDLEIKKGEITCLLGKNGCGKSTLFSLIVGLLKPNDGNIYINNLNVNT-NIDDIRSKLGICPQDDLIFQNLSVLDHlrifaiiktslngngvirnf 257
                 6899**********************************************9.*********************************************99 PP

                 .HHHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEEST CS
                 .xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  80 .esdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEp 135
                  ++d+ i+ +l++l+  ++k +++    s LSgGqk+++a a +++ +p++ll+DE 
  EFC37581.1 258 kDMDKIIDSILNELEFMDFKYKIA----SDLSGGQKRKLAFAISIIGNPEILLIDEV 310
                 888888******************....****************************6 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 8.7
                 E-SS--S-TTSBHHH CS
                 xxxxxxxxxxxxxxx RF
    ABC_tran  64 lpqepqlfpeltvre 78 
                 lpq p+lf++lt ++
  EFC37581.1 426 LPQFPTLFKQLTEKK 440
                 788888888887433 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1       3.8   6.3e+03      67      83 ..     102     118 ..      82     155 .. 0.50
   2 !   17.6   1.3   1.6e-06    0.0027       1      26 [.     172     203 ..     172     232 .. 0.69
   3 !   34.8   0.1   9.5e-12   1.5e-08     168     299 ..     237     343 ..     223     347 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.8
      AAA_21  67 sqgvryryglrlersqv 83 
                 ++ + ++++ ++ ++  
  EFC37581.1 102 QNQSIFEFFKNITQQEQ 118
                 33333333333333333 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 1.6e-06
      AAA_21   1 lnvliGpNgsGKSnLLdaldllarl......d 26 
                 +++l G+Ng+GKS+L+ ++ +l         +
  EFC37581.1 172 ITCLLGKNGCGKSTLFSLIVGLLKPndgniyI 203
                 799*****************997544433332 PP

  == domain 3  score: 34.8 bits;  conditional E-value: 9.5e-12
      AAA_21 168 llnifadyfgfakekrllqrlvrslklveielsdlgegeeliasvderlrergvvflengdgqelparelSdGtkrllalltallralkkgsllliDEp 266
                 +l+ifa   +  + ++ ++ + +  k +++ l  l++++ +++ ++++                      S G+kr la++ +++  +    +lliDE+
  EFC37581.1 237 HLRIFAIIKTSLNGNGVIRNFKDMDKIIDSILNELEFMDFKYKIASDL----------------------SGGQKRKLAFAISIIGNP---EILLIDEV 310
                 566666666666666666666666666666666666666666666555......................***************999...9******* PP

      AAA_21 267 EngLHPkllrrllellkelsrngaQviltTHSp 299
                  +g++ +    ++++l + ++ng  ++ltTH+ 
  EFC37581.1 311 SSGMDIQNRQLIWTILQKFRKNGKIIFLTTHQM 343
                 *******************9955555*****86 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.6   1.0   5.4e-10   8.8e-07      25     212 ..     171     353 ..     159     361 .. 0.62

  Alignments for each domain:
  == domain 1  score: 28.6 bits;  conditional E-value: 5.4e-10
                 SEEEEEESTTSSHHHHHHHHHHHCTT.TTTTTTCHCCCCCC--BTTCSSTTEEEEEEEEEETTEE.....SSSSSSCEEEEEEEETTSE.EEEEETTEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxx.xxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnlldAilFvLGersakklrseklsdlihkskekasvkkaeveitfdnedkk.....lkiekeevsisrrvkrkge.seykingke 117
                 ++t+++G+NG+GKs l+  i  +        l+ ++ +  i++ + + +++  + ++ +  +d+      ++   +++ i   +k++ + + +  n k+
  EFC37581.1 171 EITCLLGKNGCGKSTLFSLIVGL--------LKPNDGNIYINNLNVNTNIDDIRSKLGICPQDDLifqnlSVL--DHLRIFAIIKTSLNgNGVIRNFKD 259
                 589999********999999444........555555555555444444444444444444444411111111..223333333333221122223333 PP

                 E-H..HHHHHHHHCTT-STT...CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEEEE CS
                 xxx..xxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 118 vtk..kevsellesagiske...lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreemlekadklvgv 211
                 + k    + + le ++++ +    LSgG+k      L fAi  +    + l+De+ + +D +n++ + ++l++ +kn  +i  +  ++++e+ad++  +
  EFC37581.1 260 MDKiiDSILNELEFMDFKYKiasDLSGGQKR----KLAFAISIIGNPEILLIDEVSSGMDIQNRQLIWTILQKFRKNGKIIFLT--THQMEEADAISDI 352
                 333336666666666555445558******8....5668899999999*****************************9877654..4556666666555 PP

                 E CS
                 x RF
       SMC_N 212 t 212
                  
  EFC37581.1 353 I 353
                 4 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   5.5e-07    0.0009      16      50 ..     164     198 ..     158     206 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 5.5e-07
      AAA_29  16 tieidlkgatlltGpsGsGKSTllDAiqalLvpak 50 
                 ++ei+  ++t l G++G GKSTl+  i  lL p+ 
  EFC37581.1 164 DLEIKKGEITCLLGKNGCGKSTLFSLIVGLLKPND 198
                 67888555****************88888988887 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.1   3.4e-06    0.0056      16     113 ..     166     271 ..     153     338 .. 0.69

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 3.4e-06
    ATPase_2  16 erepneiyfiYGpegsGKtaLlkeiienledkdkyviyyialr.eesiskldefie..........eeeekkklekal............giavpkael 91 
                 e ++ ei  + G  g+GK++L+  i+  l+  ++  iy+++l+ + +i+ ++++++          +          l            ++ ++ + +
  EFC37581.1 166 EIKKGEITCLLGKNGCGKSTLFSLIVGLLKP-NDGNIYINNLNvNTNIDDIRSKLGicpqddlifqN----------LsvldhlrifaiiKTSLNGNGV 253
                 4556789999*************99999966.779*******8467888899888865555544442..........2233333332222334444444 PP

    ATPase_2  92 eeilkeksklvfkaiellleki 113
                      ++ k+++k i+++l+++
  EFC37581.1 254 I----RNFKDMDKIIDSILNEL 271
                 3....33444444444444444 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   8.7e-06     0.014       3      85 ..     174     271 ..     172     322 .. 0.82
   2 ?   -0.7   0.0      0.82   1.3e+03      45      47 ..     314     316 ..     293     373 .. 0.55

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 8.7e-06
                 EEE--SSSSHHHHHHHGGGGB...S--EEEEE--TT--HHHHH--B--..........--------...........G-SEEEEESGGG--HHHHHHH CS
       AAA_5   3 lLvGppGtgKselaerlaaal...nreveyvqltrdtteedlkgrreik.ngttslvdsplvraar...........egeilvlDEveraesevlnsL 85 
                 +L+G+ G+gKs+l   +  +l     ++ + +l+ +t+ +d++ ++ i  +++  +++ ++ +  r           +g i  + + +++ +++ln+L
  EFC37581.1 174 CLLGKNGCGKSTLFSLIVGLLkpnDGNIYINNLNVNTNIDDIRSKLGICpQDDLIFQNLSVLDHLRifaiiktslngNGVIRNFKDMDKIIDSILNEL 271
                 9**********************889999999**********99999888888888888887777777777777776555555555555555555555 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.82
                 B-- CS
       AAA_5  45 rei 47 
                 ++i
  EFC37581.1 314 MDI 316
                 333 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.2   4.8e-06    0.0079      77     122 ..     147     193 ..      95     220 .. 0.74
   2 ?   -2.7   0.0       2.9   4.7e+03     112     132 ..     418     438 ..     388     458 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 4.8e-06
                  SEEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase  77 yevllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinallpe 122
                  +++++ +++  + l+el  ++k+ ++++l+G+ G GKStL   +++ 
   EFC37581.1 147 LNLFKPKTEILTVLNELDLEIKKgEITCLLGKNGCGKSTLFSLIVGL 193
                  344444445557788999999988****************9988775 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.9
                  HHHHHHHHCTT-----S---- CS
  RsgA_GTPase 112 KStLinallpelelktgevse 132
                  K tL n llp+  +  +++ e
   EFC37581.1 418 KCTLSNDLLPQFPTLFKQLTE 438
                  777777777765444444444 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.1   1.3e-05     0.021       8     150 ..     159     352 ..     152     366 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.3e-05
                 HHHHHHCTTTSCSEEEEEEESTTSSHHHHHHHHCCSHCCCCC.CBTEEEEE............................................EEES CS
      NB-ARC   8 viekLlekdelqslvvalvGmgGvGKttlakqilnksdeveg.rFdsvawv............................................vvsk 61 
                 v ++L+ + + +  +  l G+ G+GK+tl++ i+  ++  +g  +     v                                            v+ +
  EFC37581.1 159 VLNELDLEIKKG-EITCLLGKNGCGKSTLFSLIVGLLKPNDGnIYINNLNVntniddirsklgicpqddlifqnlsvldhlrifaiiktslngngVIRN 256
                 556665433333.58899****************997776663455555559999***************************************99999 PP

                 XXHHHHHHHXXHHHHHCCCTTSSSS-STTS...HHHHHHHHCCCTTEEEEEEEE-SHHH.......H.....HHHHCHTTSEEEEEESBCCCCCCS-S- CS
      NB-ARC  62 tdkseeiletilkeLslseddleekeeves...lkrklvrlLltkrfllvlDDVweeed.......wdkigvvlparenrlrvllTTRdeevanavsat 150
                   +  +i+++il+eL+  + + ++ ++      +k      +++   +l++D V    d       w   ++  + r+n+  + lTT ++e a+a+s+ 
  EFC37581.1 257 FKDMDKIIDSILNELEFMDFKYKIASDLSGgqkRKLAFAISIIGNPEILLIDEVSSGMDiqnrqliW---TILQKFRKNGKIIFLTTHQMEEADAISDI 352
                 9999***********99977777777766683344444566778899*****998776644444444...334445688889999**999988888775 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1         2   3.3e+03      27      68 ..     125     164 ..     110     170 .. 0.70
   2 ?   13.3   0.2     5e-05     0.082       2     114 ..     174     345 ..     173     351 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2
                 EEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGG CS
         AAA  27 leisgsellskyvgesekkirelfkeakekakpsilfiDEid 68 
                 l+i+  +++ k++++  +k++ +++  k k      ++ E+d
  EFC37581.1 125 LNIKIEKIT-KTFKKDTSKTNSILNLFKPKT-EILTVLNELD 164
                 677777777.788888888888887776665.4555666666 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 5e-05
                 EEESSTTSSHHHHHHHHHHHHTHE.........EEEEETTTCSSS...................................................... CS
         AAA   2 llyGppGtGKTllakavakelgve.........fleisgsellsk...................................................... 37 
                 +l G  G+GK++l + ++  l+ +          ++++  +++sk                                                      
  EFC37581.1 174 CLLGKNGCGKSTLFSLIVGLLKPNdgniyinnlNVNTNIDDIRSKlgicpqddlifqnlsvldhlrifaiiktslngngvirnfkdmdkiidsilnele 272
                 799*****************9633333334443477777777777999999999999999999999999999999999999988999999988888888 PP

                 ...........STTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHH.HHHHHHTTTSSSTEEEEEEESSGGG CS
         AAA  38 ...........yvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqL.lteldgvkkkeskvivigatnrpdk 114
                            + g +++k++  ++ +    +p il+iDE+ + +  +             qL  t l++++k+ +  i+ ++t+++++
  EFC37581.1 273 fmdfkykiasdLSGGQKRKLAFAISIIG---NPEILLIDEVSSGMDIQ-----------NRQLiWTILQKFRKN-G-KIIFLTTHQMEE 345
                 8887777655555555555555554442...58999999999998888...........333304555555553.3.366666666665 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.0    0.0051       8.3       4      26 ..     175     197 ..     173     202 .. 0.85
   2 ?    4.8   0.1     0.015        24      94     143 ..     300     351 ..     284     364 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0051
                 EE--TTSSHHHHHHHHHHHH... CS
    NTPase_1   4 iTGppGvGKtTlvkkvlellkss 26 
                 + G+ G GK+Tl++ ++ llk +
  EFC37581.1 175 LLGKNGCGKSTLFSLIVGLLKPN 197
                 5699**************99866 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.015
                 HHH-EEEE---ST.TGGG-HHHHHHHHHHHT.TTSEEEEE--SS--SHHHHH CS
    NTPase_1  94 seadviviDEiGk.mElkskkfkeaveevLk.sekpvlavihrrkdlalvee 143
                  ++++++iDE+ + m  + ++++ ++ + ++ ++k++  + h+ ++ + + +
  EFC37581.1 300 GNPEILLIDEVSSgMDIQNRQLIWTILQKFRkNGKIIFLTTHQMEEADAISD 351
                 56899******755***********999999899999999999984444433 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   6.0         1   1.7e+03     125     187 ..     100     162 ..      58     171 .. 0.60
   2 ?   13.4   5.3     5e-05     0.082      17      43 ..     165     194 ..     160     447 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1
      AAA_23 125 lgskkiilnlilflgqerfeefelkdkkerleelekeleeledekkllekl.eqekekekelee 187
                 +g++++i++++  + q+++   ++++ + ++e+++k +++ + + + + +l + + e    l+e
  EFC37581.1 100 FGQNQSIFEFFKNITQQEQ-HVNNSELNIKIEKITKTFKKDTSKTNSILNLfKPKTEILTVLNE 162
                 4555666666666666664.23334444455555555555444333322222333444444444 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 5e-05
      AAA_23  17 F...skgltlItGpNGaGKTTildAiklaL 43 
                 +   +  +t++ G+NG+GK+T++  i   L
  EFC37581.1 165 LeikKGEITCLLGKNGCGKSTLFSLIVGLL 194
                 34434479***************8886555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (470 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1169  (0.0652016); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.49
# Mc/sec: 2894.55
//
Query:       EFC37582.1  [L=348]
Description: hypothetical protein NAEGRDRAFT_81909 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.5e-05   23.6   0.1    5.5e-05   23.6   0.1    4.2  3  DUF4050   Protein of unknown function (DUF4050)


Domain annotation for each model (and alignments):
>> DUF4050  Protein of unknown function (DUF4050)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -18.0  25.4         1   1.8e+04      83      84 ..     100     164 ..       3     243 .. 0.56
   2 !    3.4   0.2    0.0049        87      41      65 ..     275     299 ..     238     311 .. 0.76
   3 !   23.6   0.1   3.1e-09   5.5e-05     150     183 .]     314     348 .]     302     348 .] 0.79

  Alignments for each domain:
  == domain 1  score: -18.0 bits;  conditional E-value: 1
     DUF4050  83 s...............................................................e 84 
                 +                                                               +
  EFC37582.1 100 TnlfrrqstssgsggeattiggiinpttsvpslqtvsgglvggimmgaatttghthhhhpnnsnT 164
                 03333334444444445555555555555555555555555555555554433222222222221 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.0049
     DUF4050  41 GlalWearRdaWtgartvrkkekke 65 
                 G   W+a R+aW+     ++k++  
  EFC37582.1 275 GYERWKAIRNAWVTGAFASDKQTII 299
                 8889********8655545544444 PP

  == domain 3  score: 23.6 bits;  conditional E-value: 3.1e-09
     DUF4050 150 sklvvqskt.psvpInLsdmikalVqgWkadgeWp 183
                 + lv  +k+ +++pI+L+dmi++l ++W++dg ++
  EFC37582.1 314 EHLVNPKKPaFQKPIPLNDMIQILLEIWESDGLFE 348
                 556655554377********************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1790  (0.0998383); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2064.83
//
Query:       EFC37583.1  [L=525]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.7e-09   36.4   6.1      1e-08   35.6   6.1    1.4  1  GPS              GPCR proteolysis site, GPS, motif
  ------ inclusion threshold ------
       0.34   11.2   5.1        1.4    9.3   0.1    2.7  2  DUF3382          Domain of unknown function (DUF3382)


Domain annotation for each model (and alignments):
>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.6   6.1   1.1e-12     1e-08       2      43 ..     188     225 ..     187     227 .. 0.90

  Alignments for each domain:
  == domain 1  score: 35.6 bits;  conditional E-value: 1.1e-12
         GPS   2 sCvfWdeeneetgsWsteGCeltesdnknetvCsCnHLtsFA 43 
                 +C ++   n++t++W t+GC+l+   ++  ++CsC+H+tsF+
  EFC37583.1 188 TCRYY---NTTTSGWRTNGCKLVGK-DDKFITCSCDHTTSFS 225
                 8****...6789*********7776.9999***********8 PP

>> DUF3382  Domain of unknown function (DUF3382)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   1.3      0.02   1.8e+02       7      24 ..     270     287 ..     267     317 .. 0.77
   2 ?    9.3   0.1   0.00015       1.4      29      95 ..     344     410 ..     341     412 .. 0.76

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.02
     DUF3382   7 liaallalvlfvpilGlq 24 
                 +i+++l+l+++++++Gl 
  EFC37583.1 270 VISGILLLLIVSVMVGLI 287
                 79**************94 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00015
     DUF3382  29 gtrlvleprwglvaiavavvfvgqLlrplllqalkarkklkkveskadgvlvltqrwiillllvvAl 95 
                 +++lv++++++ vai+  +v + + ++  +  ++ ++  ++k+e+++++   l+++  ill+ v+Al
  EFC37583.1 344 SISLVVTTSLTAVAICSYMVVCIRYIMYRYYYQWMSAVISQKLEKATSRGIRLFKNNTILLVSVFAL 410
                 789**************99999987665555555554666677777777777788888888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (525 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1565  (0.0872888); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.35s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 2969.32
//
Query:       EFC37584.1  [L=346]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.051   13.4   0.1      0.073   12.9   0.1    1.2  1  Med18            Med18 protein
       0.11   12.0   1.1       0.16   11.4   1.1    1.2  1  HGTP_anticodon2  Anticodon binding domain of tRNAs


Domain annotation for each model (and alignments):
>> Med18  Med18 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   8.2e-06     0.073      45     166 ..      63     234 ..      26     238 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 8.2e-06
                 ......SSSSS--CTTTSEEEEEEGTTSH..............TTSSTGCC......................TS-EEEEEE----SS-SSS-EEEEEE CS
       Med18  45 vfkpkflpgkvnqieqlymklittlndekedyslkviekvkeddsdieakklfseeekve.............erpwtLqisDiPeagknqkvlvrtiy 130
                 ++++kf++ k ++ e+ y   i+  ++ + +++  + +   e++  i   + f+ e++v+               + + ++ ++P+a+  +k  +  ++
  EFC37584.1  63 AVQVKFEKLKGGKSEKRYKLIINYPKERSGEIKFSISKYCIEKKQVIVLIEDFKLEKSVSlfvgriaaeskifMIELKEEYIGMPIAKVAEKLFAPHCI 161
                 45788888887777776666666655555566655555555556666666667777777788888888766666666668999**************** PP

                 EEEE.....................................ESS-HTHHHHHT..TEEEEEEEEEEEEEEEET CS
       Med18 131 estlv...................................erkdsllqfledl..GysvineYivkGvrFfhg 166
                 + +++                                   +++ ++  +l +l  Gy+  n+++vkG+ F+ g
  EFC37584.1 162 DKSVTsegcmiinpnlffvdepsqmikttcdmamgmfdpsGNHSHIEPVLHQLsiGYRKYNQIWVKGFSFMNG 234
                 ***99***********************************9999999999876449**************975 PP

>> HGTP_anticodon2  Anticodon binding domain of tRNAs
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   1.1   1.8e-05      0.16     117     183 ..      28      95 ..       6     113 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 1.8e-05
  HGTP_anticodon2 117 skssaessqkedeassesseele.ealaskeerqkevrvlvaatrskksnkrekveqddAqeaaaelv 183
                      s ++++++++++++ss s+++++ e ++++e +++ v+v+ ++ ++ ks+kr+k+  +  +e++ e+ 
       EFC37584.1  28 SIHHSNKNKNSSSSSSLSNRKQQvELEFETEGDENAVQVKFEKLKGGKSEKRYKLIINYPKERSGEIK 95 
                      222233333333333333333335677778889********************997777777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       754  (0.0420548); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2200.75
//
Query:       EFC37585.1  [L=626]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-09   37.8  16.3      4e-08   33.8  16.3    2.9  1  SET       SET domain


Domain annotation for each model (and alignments):
>> SET  SET domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.8  16.3   2.3e-12     4e-08       1     168 [.      14     348 ..      14     349 .. 0.64

  Alignments for each domain:
  == domain 1  score: 33.8 bits;  conditional E-value: 2.3e-12
                 SCEEEESSXBXTTXEEE..................EEEECCEECHHHHHHHHHH............................................. CS
                 xxxxxxxxxxxxxxxxx..................xxxxxxxxxxxxxxxxxxx............................................. RF
         SET   1 GrGvfAtedIpkgefic..................eypeeiiltkdeadksele............................................. 36 
                 Gr ++A+edI +ge+++                                    +                                             
  EFC37585.1  14 GRIIRAREDIDEGEILViekayasvlhqsninfnsH-----------------Sfcvvcqkkkimknianadlinsssaccdkstsncnnewmlcgdeg 95 
                 899*************85443333333333333320.................233333333334445555555567888888889999999999**** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
         SET  37 ................................................................................................... 36 
                                                                                                                    
  EFC37585.1  96 ceflrntvykenelmdgqsmydyllrmaeecgiefsllllvyricrkfefdfnssnelaskyfdrnkmdnllslethrdeiypehlflfkkassclker 194
                 ********9999999****************99999999999999999999999999999888888888888888888888887666555444444444 PP

                 ..........HTEEEEEXGGXX................GGSX..HHHHHHHTTSSHHHHHHHHHHHHHHHHHHTHHHHHHHXTTTSX......XXHCCC CS
                 ..........xxxxxxxxxxxx................xxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxx RF
         SET  37 ..........aylfslpeapkn................laft..kelakasastllqklakdqkqaekedtdaalkasskaesdlna......skpeag 101
                                                        +++  + ++  + +++  ++a+++ ++        + ++ k+es + +      + p ++
  EFC37585.1 195 ifldnvigeeL----------IidtfcrifvnahsithTRWWwhQSDNIIEVEKQNADTAEKEMEE--------ISQFFKHESLKSKcldspfFIPACS 275
                 43333333330..........033333322223344443333343333333333333333333333........3333333333311122222222222 PP

                 CC..HCCCHEEEETEEEEEECCCGTTGGGCEEXSSSSEEEEEEEE......TTSSEEEEEESSXBXTTEEEEEXT CS
                 xx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxx RF
         SET 102 af..saiagysidaralksgngagplarflNHsCdpNcnltvqnv......lrgprvavfAtrdIkkGeEltidY 168
                 +   +++ +++ d   +  g+g +p+++++ HsC+pNc++++++        +g+ + v + +++kkGeEl+i+Y
  EFC37585.1 276 SDreDHTENSCAD--FRDIGTGLFPMVSMFDHSCSPNCSFQTFDDmksrnsYSGNVILVQTVKKVKKGEELCISY 348
                 2234444444444..34555555***************6666666*****9999********************* PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (626 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1077  (0.0600703); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.29s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 3749.94
//
Query:       EFC37586.1  [L=728]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-08   33.6   2.7    7.4e-08   32.7   2.7    1.5  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   2.7   4.1e-12   7.4e-08       5      85 ..     583     670 ..     578     713 .. 0.81

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 4.1e-12
                 HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..SHHHHHHHH.HHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS....ST CS
         RGS   5 lledqpgrslFreFlesefseenlsFwlaveefkka..keqeelkkk.akeIyneylapsspkelnidkklreelekrleke....qp 85 
                 ll +q++ +lF++++ +efs en+ F+++ ++  ++  + +++l+k+ ++e+ + ++ p  + elni+ ++r+++ + ++k+    + 
  EFC37586.1 583 LLTNQDLYELFKDYCSKEFSLENILFFEKLKQASSNftRADSKLSKElIEEMEKDFFTPYGKYELNIPGNVRKQIIELFQKSkskgNS 670
                 688999**********************99887777775566666555***************************9999998555533 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (728 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1102  (0.0614647); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.29s 00:00:01.04 Elapsed: 00:00:00.48
# Mc/sec: 4516.42
//
Query:       EFC37587.1  [L=379]
Description: silent information regulator family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.6e-30  106.4   1.6      1e-22   80.9   0.5    2.7  3  SIR2          Sir2 family
     0.0044   16.7   0.0        1.3    8.8   0.0    2.4  2  TPP_enzyme_M  Thiamine pyrophosphate enzyme, central domain
  ------ inclusion threshold ------
       0.64    9.6   5.3        1.4    8.5   4.2    2.1  2  TF_Zn_Ribbon  TFIIB zinc-binding


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.2   7.1e-09   4.3e-05       1      25 [.      42      66 ..      42      78 .. 0.85
   2 !   80.9   0.5   1.7e-26     1e-22      57     177 .]      78     205 ..      68     205 .. 0.85
   3 ?   -1.4   0.0      0.31   1.9e+03      39      86 ..     272     324 ..     248     331 .. 0.70

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 7.1e-09
                -GGGGGGGT---SSSTTSHHHHSCH CS
        SIR2  1 GAGiStesGipdfRskeGlyaklak 25
                GAGiSt++Gi dfR+ +G+++  +k
  EFC37587.1 42 GAGISTSAGISDFRGPNGIWTMKEK 66
                9*******************97655 PP

  == domain 2  score: 80.9 bits;  conditional E-value: 1.7e-26
                 SS--HHHHHHHHHHHTTCEEEEEES-SSSHHHHTT-S..SEEETTEEEEEEEETTTSBEEECC....GGHCHHHCCTT.B-TTTCCBEEEEE--CTSB- CS
        SIR2  57 aepnaaHkalkklekkgkllrliTQNiDgLekkaGsk..kvvelHGslakakcvkcekkldke....elqeeieaekvpecekcgkllkpdvvfFGeal 149
                 + p+++H a+++l ++g+ + +  QN+DgL+ k+G +   + elHG+ +   c +c+ ++ +     ++++  ++++   ce+cg+ l   ++ FGe+l
  EFC37587.1  78 KLPTPTHMAIATLYQRGMIKYVTSQNVDGLHVKSGFSrkDISELHGNTNVELCKNCNCEYLRTfrcrNAEHVHDHKTGRMCEHCGHELEDSIINFGENL 176
                 5799*******************************98889****************998765411102333333444559******************* PP

                 S.HHHHHHHHHHHH-SEEEEES--STSTT CS
        SIR2 150 p.dklkkliekveeadlllviGtSlkVap 177
                 p d+l+++  ++++adl +v+GtSl+V p
  EFC37587.1 177 PeDQLDRAELNAKKADLAIVLGTSLRVSP 205
                 *999999999*****************98 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.31
                 HHHHH.HHHHHHHHHHCCTSS--HHHHHHHHHHH....TTCEEEEEES-SSSH CS
        SIR2  39 llvee.vfyniarellaeeaepnaaHkalkklek....kgkllrliTQNiDgL 86 
                 +++e+ +f ni+r++    + p +  ++l++le+    ++k l+  T  iD++
  EFC37587.1 272 EKEEKsIFGNIRRKIGVSLTSPIKGARILSELEMrlvcEKKILKYTTPTIDEI 324
                 33333589999999999899999999999999972222346666677777766 PP

>> TPP_enzyme_M  Thiamine pyrophosphate enzyme, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0   0.00022       1.3       1      26 [.      24      49 ..      24      55 .. 0.87
   2 !    5.6   0.0     0.002        12      69     117 ..     182     231 ..     165     249 .. 0.64

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00022
                  HHHHHHHHHH-SSEEEEE-CHHCHTT CS
  TPP_enzyme_M  1 iekaaellkaakrpvilvGggvarsg 26
                  ++++a+ll+++k +v++ G g+++s 
    EFC37587.1 24 LDELAQLLQSSKHVVFYTGAGISTSA 49
                  5899******************9885 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.002
                   HHHHHHHHH-SEEEEES-SSSTCCCTTTTTTTTTT-.EEEEEESSCCCCT CS
  TPP_enzyme_M  69 kaanealeeaDlvlalGarfddirttgsepefapea.kiihididpaeig 117
                   + a   +++aDl ++lG+ +      +  +   +++ k++ ++ +++  +
    EFC37587.1 182 DRAELNAKKADLAIVLGTSLRVSPACDLPEMCLKKGgKMVIVNLQKTPKD 231
                   55666789**********99774444433333444457777776655544 PP

>> TF_Zn_Ribbon  TFIIB zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   4.2   0.00024       1.4       3      34 ..     130     170 ..     129     172 .. 0.91
   2 ?   -1.5   0.0      0.32   1.9e+03      24      32 ..     348     355 ..     347     361 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00024
                   ETTTTCEEC..........HEETSTTCEEESSSSBEEEECCC CS
  TF_Zn_Ribbon   3 CPnCgstnl..........veDpergelvCtdCGlVlednsi 34 
                   C+nC+ ++l          v D+++g   C+ CG  led +i
    EFC37587.1 130 CKNCNCEYLrtfrcrnaehVHDHKTGR-MCEHCGHELEDSII 170
                   9999999988999999999****9886.5**********988 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.32
                   SSSBEEEEC CS
  TF_Zn_Ribbon  24 dCGlVledn 32 
                   +C+lVl+ n
    EFC37587.1 348 ECELVLD-N 355
                   7****97.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (379 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       750  (0.0418317); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2173.55
//
Query:       EFC37588.1  [L=465]
Description: hypothetical protein NAEGRDRAFT_81868 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.012   16.1   4.4      0.012   16.1   4.4    7.2  8  Dickkopf_N  Dickkopf N-terminal cysteine-rich region


Domain annotation for each model (and alignments):
>> Dickkopf_N  Dickkopf N-terminal cysteine-rich region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   2.1    0.0054        96      28      51 ..      64      88 ..      41      89 .. 0.80
   2 ?   -0.7   0.1      0.12   2.1e+03       2       9 ..      99     106 ..      91     109 .. 0.61
   3 ?   -1.4   0.1      0.19   3.4e+03      45      51 ..     124     130 ..     121     137 .. 0.80
   4 ?    3.0   1.4    0.0079   1.4e+02       7      29 ..     155     176 ..     143     186 .. 0.81
   5 ?   16.1   4.4   6.7e-07     0.012       7      48 ..     199     241 ..     196     243 .. 0.86
   6 ?    7.6  12.1   0.00029       5.1       6      52 .]     231     283 ..     226     283 .. 0.90
   7 ?   -2.1  13.3      0.31   5.6e+03       2      48 ..     294     334 ..     293     336 .. 0.85
   8 ?   -3.6   0.0      0.94   1.7e+04      34      40 ..     347     353 ..     343     357 .. 0.57

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0054
  Dickkopf_N 28 rkrrkrCtrdaeCcpg.nlCvngvC 51
                +k++ +Ct+ ++C      Cvn +C
  EFC37588.1 64 QKKEISCTSTSDCLFTsLECVNHKC 88
                467779*******755278****** PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.12
  Dickkopf_N   2 ClsDedCg 9  
                 C++D +C 
  EFC37588.1  99 CVDDMQCI 106
                 55555553 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.19
  Dickkopf_N  45 lCvngvC 51 
                  C+n+ C
  EFC37588.1 124 KCINNRC 130
                 5888888 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.0079
  Dickkopf_N   7 dCgkgkyClssseessvClpcrk 29 
                 dC+ g+ C++   +s +C+p  +
  EFC37588.1 155 DCKVGSICSTYGTGS-KCVPKLS 176
                 9********999988.9*98654 PP

  == domain 5  score: 16.1 bits;  conditional E-value: 6.7e-07
  Dickkopf_N   7 dCgkgkyClssseessvClpcrkrrkrCtrda.eCcpgnlCvn 48 
                  C++g+yC+s s++s++C++   + + C++++  C  g++C+ 
  EFC37588.1 199 YCESGSYCKSLSDGSQICVEPLIKGSICANSTtRCQDGTVCRQ 241
                 6***************************987615667799986 PP

  == domain 6  score: 7.6 bits;  conditional E-value: 0.00029
  Dickkopf_N   6 edCgkgkyClssseess..vClpcrkrrkrCtrdaeCcpg....nlCvngvCv 52 
                 + C+ g+ C ++s ++s  +C+++ +  ++C  d++C+ g      C n++C+
  EFC37588.1 231 TRCQDGTVCRQNSPTDStfTCQNIATYGESCVLDSDCAYGttqfVKCYNNKCQ 283
                 57***********999999*********************666667******5 PP

  == domain 7  score: -2.1 bits;  conditional E-value: 0.31
  Dickkopf_N   2 ClsDedCgkgkyClssseessvClpcrkrrkrCtrdaeCcpgnlCvn 48 
                 C +D++C   +yC+ + +    C++ r+++  C+ +++C   + C  
  EFC37588.1 294 CKQDDECY-TRYCSPEGR----CAE-RSNNIPCSTSNDCPFREGCAC 334
                 99*****5.68**87766....999.*************98877765 PP

  == domain 8  score: -3.6 bits;  conditional E-value: 0.94
  Dickkopf_N  34 CtrdaeC 40 
                 C+++ +C
  EFC37588.1 347 CASNLQC 353
                 4444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (465 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       634  (0.0353617); expected 358.6 (0.02)
Passed bias filter:                      222  (0.0123822); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2708.26
//
Query:       EFC37589.1  [L=824]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.5e-08   32.1   0.0    1.6e-07   31.3   0.0    1.3  1  Fibrinogen_C  Fibrinogen beta and gamma chains, C-terminal gl
  ------ inclusion threshold ------
      0.084   12.2   0.0       0.17   11.2   0.0    1.4  1  COLFI         Fibrillar collagen C-terminal domain
       0.12   12.9   1.8       0.25   11.8   1.8    1.5  1  NUDE_C        NUDE protein, C-terminal conserved region
       0.29   11.5   1.4        5.5    7.5   0.3    2.5  2  FlaC_arch     Flagella accessory protein C (FlaC)
       0.41   11.0   3.9       0.98    9.8   3.9    1.6  1  BLOC1_2       Biogenesis of lysosome-related organelles compl


Domain annotation for each model (and alignments):
>> Fibrinogen_C  Fibrinogen beta and gamma chains, C-terminal globular domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.3   0.0   4.5e-11   1.6e-07       4      51 ..     649     697 ..     647     704 .. 0.89

  Alignments for each domain:
  == domain 1  score: 31.3 bits;  conditional E-value: 4.5e-11
                   SHHHHHHTT--.S-EEEEE-SSTTS--EEEEEE-SCCCS-EEEEEEESS CS
  Fibrinogen_C   4 dCedaakkGak.tsglytitpdkakkafevyCdmetdggGWtvlqkrld 51 
                    C++ +k  +k  sgly i+pd++++++ vyCd  t+ggGW+++  r++
    EFC37589.1 649 SCQEYMKSMTKaPSGLYWIKPDESQSKYIVYCDQVTSGGGWILVSSRKN 697
                   5999888755516**********************************98 PP

>> COLFI  Fibrillar collagen C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   4.7e-05      0.17      32      72 ..     649     688 ..     644     743 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4.7e-05
       COLFI  32 tCkdlklshpelksgeyWiDPnqGcakDaikvfCnlet.get 72 
                 +C++   s +++ sg yWi P++  +k    v+C+  t g  
  EFC37589.1 649 SCQEYMKSMTKAPSGLYWIKPDESQSK--YIVYCDQVTsGGG 688
                 79********************97655..679**97665544 PP

>> NUDE_C  NUDE protein, C-terminal conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.8   6.9e-05      0.25      85     151 ..     589     657 ..     550     676 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 6.9e-05
      NUDE_C  85 ekrspavqasssPviatppeksls....slatg.setatp.psPpasessdllrkvlaltsklarqrasisds 151
                 +  s+  +  s P+++t+++k  s     +  +   ++tp p Pp+s++s +++ ++    +la++++ +++ 
  EFC37589.1 589 FPSSSSKSGESQPTVSTTTTKM-SplstPV--TtPIINTPpPPPPLSDTS-KMEEAISIGDGLASCQEYMKSM 657
                 4444444444777777776665.3242222..235556651667899999.999999*********9999875 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.065   2.3e+02      16      40 ..     515     539 ..     509     542 .. 0.88
   2 ?    7.5   0.3    0.0015       5.5      23      43 ..     552     572 ..     545     573 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.065
   FlaC_arch  16 letvkkeneelsksveelkenVkdl 40 
                 l+t +++ ++l++s eel+  +k l
  EFC37589.1 515 LKTKQQQYQDLNNSMEELNLMIKAL 539
                 788999************9888866 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0015
   FlaC_arch  23 neelsksveelkenVkdllsL 43 
                 n  ++++++ +++nV+dll++
  EFC37589.1 552 NVAVNDQIDSMNRNVQDLLEI 572
                 55689**************86 PP

>> BLOC1_2  Biogenesis of lysosome-related organelles complex-1 subunit 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   3.9   0.00027      0.98      30      95 ..     516     580 ..     512     581 .. 0.93

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00027
     BLOC1_2  30 eaasekykklkdvaaslekkleklnekyeelqpylqqidqiekqvteLeeavseLDeyskeLEakf 95 
                 ++ +++y++l++++++l+  +++l  ++++ q++++++ ++++q++++  +v+ L e+ k+LE ++
  EFC37589.1 516 KTKQQQYQDLNNSMEELNLMIKALGGLSKNKQSNFSNV-AVNDQIDSMNRNVQDLLEIKKNLEMHI 580
                 577899*******************************9.58*********************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (824 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1163  (0.064867); expected 358.6 (0.02)
Passed bias filter:                      725  (0.0404373); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.81u 0.38s 00:00:01.19 Elapsed: 00:00:00.54
# Mc/sec: 4593.60
//
Query:       EFC37590.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.21   11.8   1.9       0.42   10.8   0.3    2.2  2  Spexin    Neuropeptide secretory protein family, NPQ, spexin
       0.52   11.0   8.6          1   10.1   0.2    3.1  3  YppG      YppG-like protein


Domain annotation for each model (and alignments):
>> Spexin  Neuropeptide secretory protein family, NPQ, spexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1      0.25   2.2e+03      58      73 ..      15      30 ..       3      41 .. 0.71
   2 ?   10.8   0.3   4.7e-05      0.42       7      45 ..      62     100 ..      58     109 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.25
      Spexin 58 aaalllaslekaqede 73
                 aal+la+  ka e+e
  EFC37590.1 15 LAALMLAMNVKAIEEE 30
                5899999999987754 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 4.7e-05
      Spexin   7 errnwtPqamlylkGaqGrrfl.sdqsrrkdlsdrlqler 45 
                 +++n tPqa   lk + Grr l  d+s+++ l d ++   
  EFC37590.1  62 KQQNETPQAPPQLKRTHGRRNLhQDHSEQRALRDLMRE-M 100
                 6789****************983578999999987653.3 PP

>> YppG  YppG-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   1.3     0.027   2.4e+02      17      45 ..      46      74 ..      34     106 .. 0.64
   2 ?   10.1   0.2   0.00011         1      19      75 ..     176     232 ..     159     241 .. 0.80
   3 ?    1.3   0.0     0.061   5.4e+02      63      80 ..     278     295 ..     263     300 .. 0.73

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.027
        YppG 17 sqqvyqqPlqpeeqplapqqqmpqqpspy 45
                + qv ++P + + +p+++q+++pq p+  
  EFC37590.1 46 TPQVGTKPKETKPAPTKQQNETPQAPPQL 74
                45566667777777777777777766542 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00011
        YppG  19 qvyqqPlqpeeqplapqqqmpqqpspynpyPkqqpqqkqpsqfqSlmsqFkkedGkl 75 
                 q  ++ l+ + + + +q++ ++  +p+++ Pk+  ++k+ + ++Sl++  + edGkl
  EFC37590.1 176 QFLENYLNSQRMNQLDQEKSQKVETPIKEEPKPIVEKKKREPISSLIKTETLEDGKL 232
                 444555566777777777777777899****************************86 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.061
        YppG  63 SlmsqFkkedGklDfnkm 80 
                  + ++F+   G++Df+k+
  EFC37590.1 278 EFSKSFRFPKGSVDFEKV 295
                 466788888888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1236  (0.0689386); expected 358.6 (0.02)
Passed bias filter:                      608  (0.0339115); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1951.43
//
Query:       EFC37591.1  [L=689]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00042   20.6   4.9      0.002   18.4   4.9    2.1  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   4.9   1.1e-07     0.002       5      88 ..     538     621 ..     516     642 .. 0.86

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.1e-07
                 HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTT CS
         RGS   5 lledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrk 88 
                  l++ + ++++re++ +e s en + ++  e+fk +k++   ++ +k+    y++ +s  e+ni++++r++  + +++++ s++
  EFC37591.1 538 YLNNDSFKHMLREYCIKEMSLENYKCYMSLEQFKMKKDKVIDLELMKQFETDYISLNSIYEVNIPSNVRKSFYELMKQVESSHS 621
                 578888999***************************5555556669999999************************99844443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (689 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1076  (0.0600145); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 4262.56
//
Query:       EFC37592.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       932  (0.0519828); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 2631.72
//
Query:       EFC37593.1  [L=460]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-40  137.0  12.9    1.1e-07   31.7   0.1    6.7  7  Kelch_4   Galactose oxidase, central domain
    1.1e-31  108.3  11.9      4e-07   29.9   0.0    6.7  7  Kelch_5   Kelch motif
      9e-26   89.2   8.9    6.9e-05   22.3   0.1    6.0  6  Kelch_1   Kelch motif
    1.9e-25   88.2  10.6    6.4e-05   23.1   0.1    6.3  6  Kelch_6   Kelch motif
    1.2e-24   86.0   2.5     0.0012   19.0   0.0    7.1  7  Kelch_3   Galactose oxidase, central domain
    3.8e-22   77.4  11.5    2.8e-06   27.1   0.0    5.9  6  Kelch_2   Kelch motif
  ------ inclusion threshold ------
      0.075   13.5   0.2        5.5    7.5   0.0    2.9  3  SANTA     SANTA (SANT Associated)


Domain annotation for each model (and alignments):
>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.1   0.0   6.9e-11   1.8e-07       2      43 ..      65     105 ..      64     118 .. 0.92
   2 ?   -3.5   0.1       4.4   1.1e+04       4      10 ..     121     127 ..     120     128 .. 0.85
   3 !   17.2   0.2   1.4e-06    0.0037      16      37 ..     168     189 ..     164     196 .. 0.92
   4 !   25.6   0.0   3.6e-09   9.2e-06       2      39 ..     209     246 ..     208     252 .. 0.95
   5 !   31.7   0.1   4.5e-11   1.1e-07       2      43 ..     266     307 ..     265     313 .. 0.90
   6 !   21.7   0.1   5.8e-08   0.00015      12      46 ..     331     365 ..     322     371 .. 0.88
   7 !   13.0   0.0     3e-05     0.077       1      32 [.     391     420 ..     391     421 .. 0.91

  Alignments for each domain:
  == domain 1  score: 31.1 bits;  conditional E-value: 6.9e-11
     Kelch_4   2 Raghsatsi.pdgtiylfGGrgedgtllndlylldlstntWrr 43 
                 R+ghsa+++ + ++iy+fGGr +++  l d++ + ++t++W++
  EFC37593.1  65 RIGHSAVYLaGTDEIYIFGGRESED--LCDMWSFHIPTREWTE 105
                 9********777***********99..99************85 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 4.4
     Kelch_4   4 ghsatsi 10 
                 +h+a+si
  EFC37593.1 121 DHTAVSI 127
                 7****98 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 1.4e-06
     Kelch_4  16 ylfGGrgedgtllndlylldls 37 
                 y+fGG+++   ++ndly +d++
  EFC37593.1 168 YIFGGYNSSKHFSNDLYCYDFT 189
                 9*******************97 PP

  == domain 4  score: 25.6 bits;  conditional E-value: 3.6e-09
     Kelch_4   2 RaghsatsipdgtiylfGGrgedgtllndlylldlstn 39 
                 R  h+++s+ d ++y++GG +++ ++l d++ +d+  n
  EFC37593.1 209 RSRHCMVSVKDQYLYIIGGMTDKSKTLMDVWEYDIDRN 246
                 889*******************************9877 PP

  == domain 5  score: 31.7 bits;  conditional E-value: 4.5e-11
     Kelch_4   2 Raghsatsi.pdgtiylfGGrgedgtllndlylldlstntWrr 43 
                 R +hs+++   + +iy+fGG+ ++ +++ dl+++dl   +W +
  EFC37593.1 266 RTYHSCVYSkLNHSIYMFGGIRNN-EAFQDLWRFDLRALQWFP 307
                 99*******8779***********.8**************955 PP

  == domain 6  score: 21.7 bits;  conditional E-value: 5.8e-08
     Kelch_4  12 dgtiylfGGrgedgtllndlylldlstntWrrlgs 46 
                 +g+++++GG++   ++l+ +y +d+st +W+rl +
  EFC37593.1 331 SGYFFVYGGYNFRHSFLDYIYQFDFSTLEWTRLQN 365
                 499**********9******************954 PP

  == domain 7  score: 13.0 bits;  conditional E-value: 3e-05
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtllndly 32 
                 +R g +++ + +g++++fGG +   t+lnd++
  EFC37593.1 391 ARSGMTSIITKSGDLIIFGGKSV--TCLNDMF 420
                 688889999999***********..8****98 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   6.1e-07    0.0016       2      29 ..      62      89 ..      62      94 .. 0.85
   2 ?   -1.8   0.0       1.3   3.3e+03       1      11 [.     115     125 ..     115     136 .. 0.87
   3 !   18.3   0.3   6.8e-07    0.0018      15      38 ..     165     187 ..     153     189 .. 0.86
   4 !   24.0   0.0     1e-08   2.7e-05       5      39 ..     209     243 ..     208     246 .. 0.89
   5 !   29.9   0.0   1.5e-10     4e-07       1      40 [.     262     301 ..     262     302 .. 0.91
   6 !    9.2   0.4   0.00045       1.2       1      39 [.     315     355 ..     315     357 .. 0.81
   7 !   10.3   0.0   0.00021      0.54       1      35 [.     388     420 ..     388     427 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 6.1e-07
     Kelch_5  2 PppRaghcavtvs..ekiYvyGGkvgrdgs 29
                P+ R gh+av++   ++iY++GG+ +  ++
  EFC37593.1 62 PERRIGHSAVYLAgtDEIYIFGGRES--ED 89
                889*******98669********996..55 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.3
     Kelch_5   1 iPppRaghcav 11 
                 +P+p ++h av
  EFC37593.1 115 WPSPMFDHTAV 125
                 79******999 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 6.8e-07
     Kelch_5  15 ekiYvyGGkvgrdgsvsddvyvLd 38 
                 +++Y++GG+++ ++++s+d+y +d
  EFC37593.1 165 NQMYIFGGYNS-SKHFSNDLYCYD 187
                 579*******7.*********998 PP

  == domain 4  score: 24.0 bits;  conditional E-value: 1e-08
     Kelch_5   5 Raghcavtv.sekiYvyGGkvgrdgsvsddvyvLdl 39 
                 R++hc+v v ++++Y++GG++   ++   dv+ +d+
  EFC37593.1 209 RSRHCMVSVkDQYLYIIGGMT-DKSKTLMDVWEYDI 243
                 99*****9956**********.5888888*****97 PP

  == domain 5  score: 29.9 bits;  conditional E-value: 1.5e-10
     Kelch_5   1 iPppRaghcavtv..sekiYvyGGkvgrdgsvsddvyvLdlp 40 
                 +P++R++h+ v+   +++iY++GG+   +++++ d++++dl+
  EFC37593.1 262 FPNSRTYHSCVYSklNHSIYMFGGIR--NNEAFQDLWRFDLR 301
                 6**********76447**********..************95 PP

  == domain 6  score: 9.2 bits;  conditional E-value: 0.00045
     Kelch_5   1 iPppRaghcav...tvsekiYvyGGkvgrdgsvsddvyvLdl 39 
                 +P+ R++h  +     s++ +vyGG++  ++s+ d +y++d 
  EFC37593.1 315 VPVERFRHNCFipnEESGYFFVYGGYNF-RHSFLDYIYQFDF 355
                 5888999988745455799********9.9999999999885 PP

  == domain 7  score: 10.3 bits;  conditional E-value: 0.00021
     Kelch_5   1 iPppRaghcavtv.sekiYvyGGkvgrdgsvsddvy 35 
                 iP++R+g  +++  s+ ++++GGk+       +d++
  EFC37593.1 388 IPCARSGMTSIITkSGDLIIFGGKS---VTCLNDMF 420
                 7*********98758*********9...55556655 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.0   1.1e-05     0.027      12      41 ..      77     105 ..      64     106 .. 0.87
   2 !   22.3   0.1   2.7e-08   6.9e-05      11      39 ..     164     193 ..     156     197 .. 0.90
   3 !   13.8   0.0   1.2e-05     0.031       7      35 ..     215     244 ..     208     247 .. 0.80
   4 !   18.9   0.0   3.3e-07   0.00084      10      45 ..     276     311 ..     265     312 .. 0.83
   5 !   20.8   0.1   8.2e-08   0.00021      12      43 ..     332     364 ..     331     367 .. 0.94
   6 ?   -1.7   0.0      0.86   2.2e+03      12      29 ..     403     419 ..     400     421 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.1e-05
                 TEEEEEEEBCSSSBEEEEEEEETTTTEEEE CS
     Kelch_1  12 gkiYviGGsdggnalssvevyDpetntWre 41 
                 ++iY++GG+ + + l++ + +   t +W+e
  EFC37593.1  77 DEIYIFGGRES-EDLCDMWSFHIPTREWTE 105
                 69*********.****************97 PP

  == domain 2  score: 22.3 bits;  conditional E-value: 2.7e-08
                 TTEEEEEEEBCS.SSBEEEEEEEETTTTEE CS
     Kelch_1  11 ggkiYviGGsdg.gnalssvevyDpetntW 39 
                  +++Y++GG+++   +++++++yD++ +++
  EFC37593.1 164 YNQMYIFGGYNSsKHFSNDLYCYDFTFKKF 193
                 699**********************98876 PP

  == domain 3  score: 13.8 bits;  conditional E-value: 1.2e-05
                 EEEETTEEEEEEEBCS.SSBEEEEEEEETT CS
     Kelch_1   7 avvvggkiYviGGsdg.gnalssvevyDpe 35 
                 + v + ++Y+iGG+ + ++ l +v+ yD  
  EFC37593.1 215 VSVKDQYLYIIGGMTDkSKTLMDVWEYDID 244
                 3345789*********************86 PP

  == domain 4  score: 18.9 bits;  conditional E-value: 3.3e-07
                 ETTEEEEEEEBCSSSBEEEEEEEETTTTEEEEECCC CS
     Kelch_1  10 vggkiYviGGsdggnalssvevyDpetntWrelpsM 45 
                 +++ iY +GG ++++a  +++++D++  +W ++ +M
  EFC37593.1 276 LNHSIYMFGGIRNNEAFQDLWRFDLRALQWFPIDNM 311
                 69****************************888777 PP

  == domain 5  score: 20.8 bits;  conditional E-value: 8.2e-08
                 TEEEEEEEBCS.SSBEEEEEEEETTTTEEEEEC CS
     Kelch_1  12 gkiYviGGsdg.gnalssvevyDpetntWrelp 43 
                 g+ +v GG+++ +++l+ ++ +D+ t +W++l 
  EFC37593.1 332 GYFFVYGGYNFrHSFLDYIYQFDFSTLEWTRLQ 364
                 7889**************************986 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 0.86
                 TEEEEEEEBCSSSBEEEE CS
     Kelch_1  12 gkiYviGGsdggnalssv 29 
                 g + ++GG +  ++l++ 
  EFC37593.1 403 GDLIIFGGKSV-TCLNDM 419
                 678999*9998.888875 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   3.7e-06    0.0096       2      42 ..      65     105 ..      64     107 .. 0.85
   2 !   12.4   0.2   5.7e-05      0.15      14      38 ..     167     191 ..     165     198 .. 0.83
   3 !   20.0   0.0   2.4e-07   0.00062       2      38 ..     209     246 ..     208     249 .. 0.90
   4 !   23.1   0.1   2.5e-08   6.4e-05       2      47 ..     266     312 ..     265     316 .. 0.90
   5 !   15.2   0.2   7.6e-06      0.02       7      44 ..     324     364 ..     319     368 .. 0.85
   6 ?    2.5   0.0     0.075   1.9e+02       6      22 ..     397     413 ..     391     425 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 3.7e-06
     Kelch_6   2 raghslvsvgg..kiYifGGytdsspylnkvwvydpetksWeq 42 
                 r ghs+v   g   iYifGG+    + l ++w +++ t+ W++
  EFC37593.1  65 RIGHSAVYLAGtdEIYIFGGRES--EDLCDMWSFHIPTREWTE 105
                 56899999665236*******96..899999**********96 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 5.7e-05
     Kelch_6  14 iYifGGytdsspylnkvwvydpetk 38 
                  YifGGy+ s  ++n++++yd+  k
  EFC37593.1 167 MYIFGGYNSSKHFSNDLYCYDFTFK 191
                 6*********8899*******8655 PP

  == domain 3  score: 20.0 bits;  conditional E-value: 2.4e-07
     Kelch_6   2 raghslvsvgg.kiYifGGytdsspylnkvwvydpetk 38 
                 r  h +vsv + ++Yi+GG td s++l +vw yd++ +
  EFC37593.1 209 RSRHCMVSVKDqYLYIIGGMTDKSKTLMDVWEYDIDRN 246
                 667999**7777**********************9877 PP

  == domain 4  score: 23.1 bits;  conditional E-value: 2.5e-08
     Kelch_6   2 raghslvs..vggkiYifGGytdsspylnkvwvydpetksWeqlpplp 47 
                 r++hs+v    + +iY+fGG  + ++++ ++w++d++   W ++  ++
  EFC37593.1 266 RTYHSCVYskLNHSIYMFGGIRN-NEAFQDLWRFDLRALQWFPIDNMK 312
                 99****99667789*******99.9***************99888876 PP

  == domain 5  score: 15.2 bits;  conditional E-value: 7.6e-06
     Kelch_6   7 lvsvg...gkiYifGGytdsspylnkvwvydpetksWeqlp 44 
                 +++++   g+++++GGy+  +++l+ ++ +d++t  W++l+
  EFC37593.1 324 CFIPNeesGYFFVYGGYNFRHSFLDYIYQFDFSTLEWTRLQ 364
                 5566644479*******999******************987 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.075
     Kelch_6   6 slvsvggkiYifGGytd 22 
                 s+++  g + ifGG + 
  EFC37593.1 397 SIITKSGDLIIFGGKSV 413
                 5688999*******875 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.12   3.2e+02      34      48 ..      56      72 ..      48      73 .. 0.83
   2 !    7.7   0.0    0.0017       4.3       1      33 [.      76     105 ..      76     120 .. 0.82
   3 !   19.0   0.0   4.8e-07    0.0012       2      30 ..     165     192 ..     165     216 .. 0.78
   4 !   12.5   0.0   5.4e-05      0.14       2      48 ..     220     273 ..     219     273 .. 0.74
   5 !   18.4   0.0   7.6e-07    0.0019       1      37 [.     277     311 ..     277     317 .. 0.92
   6 !   15.3   0.7   7.1e-06     0.018       2      34 ..     332     363 ..     331     379 .. 0.87
   7 ?    2.6   0.0     0.067   1.7e+02       2      22 ..     404     420 ..     403     424 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.12
     Kelch_3 34 i..aslppaRaghaata 48
                +  a+ p  R gh+a++
  EFC37593.1 56 TgfATQPERRIGHSAVY 72
                4558899*******997 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0017
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWae 33 
                 +d++yifGG+     + l d++++ + t +W+e
  EFC37593.1  76 TDEIYIFGGRE---SEDLCDMWSFHIPTREWTE 105
                 589********...9999999999999999985 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 4.8e-07
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtnt 30 
                 + +yifGG++ ++  ++nd+y yd+   +
  EFC37593.1 165 NQMYIFGGYN-SSKHFSNDLYCYDFTFKK 192
                 67********.99***********87665 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 5.4e-05
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtn...tWa....ei.aslppaRaghaata 48 
                  +lyi+GG + d  + l dv++yd+d+n          +   s p  R++h++++
  EFC37593.1 220 QYLYIIGGMT-DKSKTLMDVWEYDIDRNvmkCLSkhsdQYsESFPNSRTYHSCVY 273
                 69********.789999*********99666222232355444466*****9875 PP

  == domain 5  score: 18.4 bits;  conditional E-value: 7.6e-07
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaeiasl 37 
                 ++++y fGG +  ++++  d++++dl + +W  i+++
  EFC37593.1 277 NHSIYMFGGIR--NNEAFQDLWRFDLRALQWFPIDNM 311
                 5789*******..******************999987 PP

  == domain 6  score: 15.3 bits;  conditional E-value: 7.1e-06
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWaei 34 
                 ++++++GG++  +  +l   y +d++t +W+++
  EFC37593.1 332 GYFFVYGGYN-FRHSFLDYIYQFDFSTLEWTRL 363
                 689*******.6*******************98 PP

  == domain 7  score: 2.6 bits;  conditional E-value: 0.067
     Kelch_3   2 drlyifGGlgddgqdrlndvy 22 
                 d l ifGG+     ++lnd++
  EFC37593.1 404 D-LIIFGGKS---VTCLNDMF 420
                 5.99******...79999986 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0   4.8e-05      0.12       1      44 [.      64     105 ..      64     105 .. 0.92
   2 !   11.9   0.1   6.9e-05      0.18      11      37 ..     164     188 ..     156     195 .. 0.90
   3 !   16.6   0.1   2.1e-06    0.0055       2      45 ..     210     251 ..     209     253 .. 0.89
   4 !   27.1   0.0   1.1e-09   2.8e-06       2      45 ..     266     308 ..     265     312 .. 0.89
   5 !   12.3   0.0     5e-05      0.13      12      46 ..     332     364 ..     319     365 .. 0.82
   6 ?   -1.6   0.0       1.2     3e+03      11      19 ..     402     410 ..     391     423 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 4.8e-05
     Kelch_2   1 rrgghsssvp..ggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44 
                 rr ghs++++   + iy++GG+     ++  +d++ +   +++W+e
  EFC37593.1  64 RRIGHSAVYLagTDEIYIFGGR----ESEDLCDMWSFHIPTREWTE 105
                 799*******9899********....99999999999999999986 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 6.9e-05
     Kelch_2  11 ggkiyvvGGahtdnpnlsssdvhvldl 37 
                  +++y++GG+    + ++s+d++++d+
  EFC37593.1 164 YNQMYIFGGY--NSSKHFSNDLYCYDF 188
                 5899******..**************8 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 2.1e-06
     Kelch_2   2 rgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 + ++++sv ++ +y++GG    +++   +dv+ +d + +v +++
  EFC37593.1 210 SRHCMVSVKDQYLYIIGGM--TDKSKTLMDVWEYDIDRNVMKCL 251
                 678899999**********..****************9987766 PP

  == domain 4  score: 27.1 bits;  conditional E-value: 1.1e-09
     Kelch_2   2 rgghsssvp..ggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 r  hs++++  ++ iy++GG+    +n+++ d++ +dl+  +W + 
  EFC37593.1 266 RTYHSCVYSklNHSIYMFGGI---RNNEAFQDLWRFDLRALQWFPI 308
                 66788888888**********...*******************986 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 5e-05
     Kelch_2  12 gkiyvvGGahtdnpnlsssd.vhvldlekhvWeevt 46 
                 g  +v+GG+   n+ +s+ d ++ +d+++ +W++++
  EFC37593.1 332 GYFFVYGGY---NFRHSFLDyIYQFDFSTLEWTRLQ 364
                 889******...9999998835669*******9986 PP

  == domain 6  score: -1.6 bits;  conditional E-value: 1.2
     Kelch_2  11 ggkiyvvGG 19 
                  g ++++GG
  EFC37593.1 402 SGDLIIFGG 410
                 588999999 PP

>> SANTA  SANTA (SANT Associated)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.078     2e+02       7      31 ..      16      38 ..      10      56 .. 0.66
   2 ?    7.5   0.0    0.0022       5.5      34      67 ..     202     235 ..     193     250 .. 0.88
   3 ?   -2.8   0.0       3.6   9.2e+03      43      60 ..     394     411 ..     390     416 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.078
       SANTA  7 wlkkveketeklaveGfrkdseeqq 31
                ++ +  ++++k+aveG++++ +e  
  EFC37593.1 16 YMNH--NKKSKIAVEGVNRKPKEDF 38
                4444..33337******88777665 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0022
       SANTA  34 hSsaIvkrvdsttletasgsiyiLegkineektr 67 
                 +S++I++r  ++++  ++   yi+ g+ +++kt 
  EFC37593.1 202 ESEMIMERSRHCMVSVKDQYLYIIGGMTDKSKTL 235
                 699**************************99975 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 3.6
       SANTA  43 dsttletasgsiyiLegk 60 
                   t++ t+sg  +i+ gk
  EFC37593.1 394 GMTSIITKSGDLIIFGGK 411
                 567889999999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       443  (0.0247086); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.51u 0.23s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 3139.88
//
Query:       EFC37594.1  [L=330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.6e-16   60.1   0.8    4.7e-16   59.3   0.8    1.4  1  TLD             TLD
  ------ inclusion threshold ------
      0.086   12.5   0.1       0.15   11.7   0.1    1.4  1  DNA_mis_repair  DNA mismatch repair protein, C-terminal domai


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.3   0.8   5.2e-20   4.7e-16       1     138 [.     187     329 ..     187     330 .] 0.87

  Alignments for each domain:
  == domain 1  score: 59.3 bits;  conditional E-value: 5.2e-20
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnk.kfygdsesflfsl......spkfkvykstgknkaylntssdglgfGgg 92 
                 l+y+ s+dg s+ +++ k++nkg t++lik++ + +fG+++s +w+s+ +     d++ f fs+      +  +kv+++ +k +a++n  ++g++fGgg
  EFC37594.1 187 LIYRGSRDGLSVASFHAKCDNKGATVTLIKSTSGAVFGGYTSLSWRSEASlTANADASAFMFSVisatkeERFVKVLQNANKAYAMYNYVTYGPTFGGG 285
                 69*******************************************76666467888**********98866667788889999999999999*****96 PP

         TLD  93 qpkfsLwidsslekgtsrhsetfengllsg...aseerfkikdiEVWgl 138
                    +++++  +   +++++ +t++ g++++   ++ + f   +iE++++
  EFC37594.1 286 ---HDMCVKFNTL-SYFNP-NTYGYGIITNdyySGGQYFTEAEIEIYTI 329
                 ...6988875554.56666.99999999999998999999999**9987 PP

>> DNA_mis_repair  DNA mismatch repair protein, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   1.7e-05      0.15      32      62 ..      77     107 ..      53     116 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.7e-05
                     CCG-BTTGGEEEEEETTEEE--HHHHHHHHH CS
  DNA_mis_repair  32 pelsrskrdkqflfvNgRlvkskelkkaire 62 
                     + +++++++ +++++N+R+v+ ++lk ai +
      EFC37594.1  77 NATANANTTDMLTIINKRVVQLNKLKSAIYS 107
                     3477889999******************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1019  (0.0568353); expected 358.6 (0.02)
Passed bias filter:                      543  (0.0302861); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1966.74
//
Query:       EFC37595.1  [L=350]
Description: cathepsin B-like cysteine proteinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.5e-60  202.9   4.7    8.5e-60  202.5   4.7    1.2  1  Peptidase_C1    Papain family cysteine protease
    5.5e-06   25.4   4.3     0.0027   16.5   0.5    2.1  2  Peptidase_C1_2  Peptidase C1-like family
    0.00052   19.8   0.0     0.0012   18.7   0.0    1.6  1  Propeptide_C1   Peptidase family C1 propeptide


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  202.5   4.7   1.4e-63   8.5e-60       2     215 ..     126     344 ..     125     347 .. 0.88

  Alignments for each domain:
  == domain 1  score: 202.5 bits;  conditional E-value: 1.4e-63
                   TSCEETTTTTTG.SG---B-TSSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS--SSSCS CS
  Peptidase_C1   2 pesvDwrekgga.vtpvkdqgsCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdypYkakeg 96 
                   p+++D+re+  + ++++k+q++CGsCWafsa ++l dr++ik++ k +v+lS q +v+Cs+ +n+gCnGG+ + +++++++ g v+e++ pY +  g
    EFC37595.1 126 PTQFDAREQWPQcIRSIKNQKNCGSCWAFSASSVLADRFCIKSGgKVNVDLSPQFMVSCSG-QNNGCNGGFFDATWRFLVSVGTVSEACVPYVSFGG 221
                   99******76666*******************************999*************9.8******************************5544 PP

                   ..SS-CGCGGGSEEBEESEEEEEESS...BHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEEEEEET..TEEEEEEE- CS
  Peptidase_C1  97 ..gkCkkkkkkekvakikgygkvken...seealkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivGygven..gkkyWivkN 186
                     + C+ k++    +k   y+  +++    + ++++ l++ngP++va+ +++ df +YksGvy++ + +     hav+ivG+g ++  + +yWi++N
    EFC37595.1 222 avPACNVKSCGVPGQKSPFYRAGSARkleGMLDIMADLKANGPIQVAMGVYR-DFYSYKSGVYHHVSGR-YVGGHAVKIVGWGYDSasKLPYWICAN 316
                   457888887776644444444444443445789*******************.6***********7544.5789*********99987999****** PP

                   SBTTTSTBTTEEEEESSSSTGGGTTSSEE CS
  Peptidase_C1 187 sWgtdwgekGYiriargknnecgieseav 215
                   sWg+dwg kGY++i rg+  ecgi +++ 
    EFC37595.1 317 SWGEDWGIKGYFWILRGRG-ECGIGKMVW 344
                   *****************88.****99875 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.2   3.4e-05      0.21      57      81 ..     141     165 ..     127     182 .. 0.80
   2 !   16.5   0.5   4.6e-07    0.0027     360     396 ..     293     329 ..     284     332 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 3.4e-05
                     S--B--BSSTHHHHHHHHHHHHHHH CS
  Peptidase_C1_2  57 evtnqkqsGRCWlFaalnvlRlkll 81 
                     ++ nqk+ G CW F+a  vl  ++ 
      EFC37595.1 141 SIKNQKNCGSCWAFSASSVLADRFC 165
                     578*************999876665 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 4.6e-07
                     -EEEEEEEEEE-TTSSEEEEEEE-SBTTTSTBTTEEE CS
  Peptidase_C1_2 360 tHamvltgvdvdddgkvtkwkvEnsWGedsGekGyfv 396
                      Ha+ ++g   d+  k   w   nsWGed G kGyf 
      EFC37595.1 293 GHAVKIVGWGYDSASKLPYWICANSWGEDWGIKGYFW 329
                     6**********************************96 PP

>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.0     2e-07    0.0012       4      37 ..      53      89 ..      51      92 .. 0.94

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 2e-07
                   HHHHHHHHC.T-SEEE---..-SSBSHHHHHCCS-B- CS
  Propeptide_C1  4 efIdyiNsk.nttWkAgrN..FdnttlsyikgLlGvl 37
                   e+I +iNs+  ++W+A  +  F++ +l++   LlG+l
     EFC37595.1 53 EMISNINSQpSASWQAVEYpqFKGKSLADMTNLLGAL 89
                   9**********************77**********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       442  (0.0246528); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2158.61
//
Query:       EFC37596.1  [L=700]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-15   56.3   2.5    2.2e-11   44.2   0.1    3.2  3  Ank_2     Ankyrin repeats (3 copies)
    2.6e-12   47.0   0.3    9.9e-09   35.6   0.0    3.7  4  Ank_4     Ankyrin repeats (many copies)
    6.2e-12   45.4  14.9    6.2e-12   45.4  14.9    3.6  3  zf-MYND   MYND finger
    1.1e-11   44.6   2.0       0.09   13.3   0.0    4.7  4  Ank       Ankyrin repeat
    2.6e-09   36.6   3.0      0.032   14.8   0.0    6.0  5  Ank_3     Ankyrin repeat
    7.5e-08   32.5   0.7       0.13   12.7   0.0    5.0  4  Ank_5     Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.2   0.1   7.4e-15   2.2e-11       1      77 [.     128     214 ..     128     222 .. 0.77
   2 !   20.8   0.2   1.4e-07   0.00043      25      82 ..     190     276 ..     184     277 .. 0.72
   3 !    6.8   0.1    0.0035        10      14      82 ..     232     276 ..     220     299 .. 0.50

  Alignments for each domain:
  == domain 1  score: 44.2 bits;  conditional E-value: 7.4e-15
       Ank_2   1 LhlAakngnlelvklL.l.egadpn..k.ngktaLhyAakngnleivklLleh........adndgrtpLhyAarsghleivklLlekga 77 
                 L+lA++++  ++   L l +   +n  + ++ taLh+A +ngn+ +v+ L++         ++ dg+tpL++A++++h+e+vk +le+ a
  EFC37596.1 128 LMLACLQN--DTATALsLsSPETVNdrSiDNFTALHFAMMNGNIALVERLVKDgarldkrtITHDGMTPLIFAIKESHYECVKKFLEC-A 214
                 899***87..356666355455555443799***********9999*****96666454444499******************99987.3 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 1.4e-07
       Ank_2  25 ngktaLhyAakngnleivklLle..h................adnd........grtpLhyAars.....ghleivklLlekgadinlk 82 
                 +g+t+L++A+k+ + e+vk +le  +                +  +        g+tpLh+ ++        l ++ +L+++ga++n++
  EFC37596.1 190 DGMTPLIFAIKESHYECVKKFLEcaKlkleenselqegkltiQ--KlvnqgnllGETPLHHVCKLfmqipHALHLATILIDYGANVNAT 276
                 799***************9999955155444555544554441..034446667*****988877786655789999999999999987 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0035
       Ank_2  14 klLl.egadpnk.ngktaLhyAakn.....gnleivklLleh.adndgrtpLhyAarsghleivklLlekgadinlk 82 
                 + L+ +g    +  g+t+Lh+ +k        l+++ +L+++ a                            ++n++
  EFC37596.1 232 QKLVnQG----NlLGETPLHHVCKLfmqipHALHLATILIDYgA----------------------------NVNAT 276
                 3444222....123566666666643322222244566665552............................33332 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   4.1e-06     0.012      17      54 ..     140     175 ..     126     176 .. 0.73
   2 !   35.6   0.0   3.3e-12   9.9e-09       3      55 .]     158     211 ..     156     211 .. 0.96
   3 ?    2.9   0.0     0.059   1.7e+02      32      44 ..     239     251 ..     212     256 .. 0.77
   4 !    6.6   0.0    0.0042        13       3      41 ..     244     288 ..     242     292 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 4.1e-06
       Ank_4  17 vrlLlekgad.inaqdnrsGetalhiAakrgnveilklL 54 
                 + +L  + ++ +n + +++ +talh+A ++gn+  ++ L
  EFC37596.1 140 ALSL--SSPEtVNDR-SIDNFTALHFAMMNGNIALVERL 175
                 4333..334469999.99****************99977 PP

  == domain 2  score: 35.6 bits;  conditional E-value: 3.3e-12
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaq.dnrsGetalhiAakrgnveilklLl 55 
                 taLh a++ g++ lv++L+  ga ++++ +  +G+t+l++A+k +++e++k +l
  EFC37596.1 158 TALHFAMMNGNIALVERLVKDGARLDKRtITHDGMTPLIFAIKESHYECVKKFL 211
                 79**************************999*******************9876 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.059
       Ank_4  32 nrsGetalhiAak 44 
                 n  Get+lh+++k
  EFC37596.1 239 NLLGETPLHHVCK 251
                 4559******996 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0042
       Ank_4   3 taLhyaai.....sgrlelvrlLlekgadinaqdnrs.Getalhi 41 
                 t+Lh+ ++        l l+ +L+++ga++na++ +   et+l +
  EFC37596.1 244 TPLHHVCKlfmqiPHALHLATILIDYGANVNATAVGLlKETPLLY 288
                 7899999999999999999*************9543336677666 PP

>> zf-MYND  MYND finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -26.8  28.3         6   1.8e+04      24      38 .]      51      65 ..       7      73 .. 0.73
   2 ?  -11.1   7.7         6   1.8e+04      22      34 ..      79      91 ..      78      93 .. 0.68
   3 !   45.4  14.9   2.1e-15   6.2e-12       1      38 []     653     694 ..     653     694 .. 0.96

  Alignments for each domain:
  == domain 1  score: -26.8 bits;  conditional E-value: 6
                HHHHHHCHHHHCCCH CS
     zf-MYND 24 keCqradwksHkteC 38
                ++C +++  +H + C
  EFC37596.1 51 ENCSHEHHHHHDENC 65
                556666666666666 PP

  == domain 2  score: -11.1 bits;  conditional E-value: 6
                SSHHHHHHCHHHH CS
     zf-MYND 22 CskeCqradwksH 34
                Cs ++ + +  +H
  EFC37596.1 79 CSHDHGHHHHHHH 91
                7777777666666 PP

  == domain 3  score: 45.4 bits;  conditional E-value: 2.1e-15
                 -TTT--.....B-SCE-TTTS-SEESSHHHHHHCHHHHCCCH CS
     zf-MYND   1 CavCgk....aealkkCagCksvfYCskeCqradwksHkteC 38 
                 Ca+C+k    + +lk+C+gC++vfYCs +Cq+ +w+sHkt C
  EFC37596.1 653 CANCNKtgtkSAPLKRCSGCQKVFYCSGNCQKTHWSSHKTAC 694
                 ******999888888**************************9 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0      0.03        88       3      12 ..     125     135 ..     125     150 .. 0.76
   2 !   13.3   0.0     3e-05      0.09       1      31 [.     155     186 ..     155     187 .. 0.90
   3 !   10.1   0.0    0.0003      0.89       1      22 [.     190     211 ..     190     220 .. 0.88
   4 !   12.8   0.6   4.3e-05      0.13       2      30 ..     242     276 ..     241     277 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.03
                 BBHHHHHH.HH CS
         Ank   3 nTPLHlAa.tn 12 
                 ++PL+lA+ +n
  EFC37596.1 125 FSPLMLAClQN 135
                 68******533 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 3e-05
                 TSBBHHHHHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   1 dGnTPLHlAatngkkriiklLL.hGAnlnald 31 
                 d +T+LH A +ng+   ++ L+ +GA l+ ++
  EFC37596.1 155 DNFTALHFAMMNGNIALVERLVkDGARLDKRT 186
                 679*******************99*9888776 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.0003
                 TSBBHHHHHHHHTTHHHHHHHH CS
         Ank   1 dGnTPLHlAatngkkriiklLL 22 
                 dG+TPL  A+ + + +++k +L
  EFC37596.1 190 DGMTPLIFAIKESHYECVKKFL 211
                 9*********999999**9888 PP

  == domain 4  score: 12.8 bits;  conditional E-value: 4.3e-05
                 SBBHHHHHH....HHTT.HHHHHHHH.TTTSTTCB CS
         Ank   2 GnTPLHlAa....tngk.kriiklLL.hGAnlnal 30 
                 G TPLH  +    ++ + ++ +  L+ +GAn+na+
  EFC37596.1 242 GETPLHHVCklfmQIPHaLHLATILIdYGANVNAT 276
                 89****9789888777766677789977*****96 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.022        66       4      16 ..     126     138 ..     123     145 .. 0.83
   2 !   14.8   0.0   1.1e-05     0.032       2      29 ..     156     182 ..     155     184 .. 0.89
   3 ?    5.4   0.0     0.012        35       1      23 [.     190     212 ..     190     216 .. 0.91
   4 !    5.9   0.3    0.0083        25       2      11 ..     242     251 ..     241     275 .. 0.79
   5 ?   -1.2   0.0       1.7   5.1e+03       3      16 ..     283     296 ..     282     302 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.022
       Ank_3   4 tpLhlAarsgnle 16 
                 +pL+lA+++++++
  EFC37596.1 126 SPLMLACLQNDTA 138
                 8********9875 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 1.1e-05
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                 + t+Lh+A+++gn+++v+ L++  ga +
  EFC37596.1 156 NFTALHFAMMNGNIALVERLVK-DGARL 182
                 67********************.88865 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.012
       Ank_3   1 nGetpLhlAarsgnleivkfLle 23 
                 +G+tpL +A++  ++e vk +le
  EFC37596.1 190 DGMTPLIFAIKESHYECVKKFLE 212
                 69**************9999888 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.0083
       Ank_3   2 GetpLhlAar 11 
                 GetpLh++++
  EFC37596.1 242 GETPLHHVCK 251
                 99******96 PP

  == domain 5  score: -1.2 bits;  conditional E-value: 1.7
       Ank_3   3 etpLhlAarsgnle 16 
                 etpL + ars ++e
  EFC37596.1 283 ETPLLYFARSVPPE 296
                 8******9997775 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.053   1.6e+02      10      28 ..     118     136 ..     113     143 .. 0.81
   2 !    6.8   0.0     0.003         9       9      36 ..     149     176 ..     140     186 .. 0.82
   3 !   12.7   0.0   4.2e-05      0.13      15      36 ..     190     211 ..     183     221 .. 0.89
   4 ?    4.1   0.1      0.02        59       8      25 ..     234     251 ..     229     278 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.053
       Ank_5  10 nrldgggntpLhvAakyga 28 
                 n +  + ++pL++A+ ++ 
  EFC37596.1 118 NKKHVKTFSPLMLACLQND 136
                 566677899******9886 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.003
       Ank_5   9 vnrldgggntpLhvAakygaadvvrlLl 36 
                 vn++  + +t+Lh+A  +g+  +v++L+
  EFC37596.1 149 VNDRSIDNFTALHFAMMNGNIALVERLV 176
                 677777788******************9 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 4.2e-05
       Ank_5  15 ggntpLhvAakygaadvvrlLl 36 
                 +g+tpL++A+k  + ++v+++l
  EFC37596.1 190 DGMTPLIFAIKESHYECVKKFL 211
                 69*******************9 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.02
       Ank_5   8 dvnrldgggntpLhvAak 25 
                  vn  +  g+tpLh+ +k
  EFC37596.1 234 LVNQGNLLGETPLHHVCK 251
                 688899999******998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (700 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       953  (0.0531541); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.82u 0.30s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 4061.07
//
Query:       EFC37597.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1147  (0.0639746); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1910.68
//
Query:       EFC37598.1  [L=119]
Description: Hypothetical protein NAEGRDRAFT_74638 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00031   20.5   0.0    0.00045   20.0   0.0    1.3  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.011   15.6   0.0      0.017   15.0   0.0    1.3  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.0   5.1e-08   0.00045       6      46 ..      35      75 ..      32      77 .. 0.90

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 5.1e-08
                S-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHHH CS
       F-box  6 LPsevlrhILerLplsdllalrrVSkgwrilidsdrlwcks 46
                +P ev +h ++++p +dl +l + Sk++++ i +    +++
  EFC37598.1 35 VPVEVKLHTFSYVPMKDLPNLLLISKRLKNSILGFDNLFEI 75
                799***************************99888776665 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.0   1.9e-06     0.017       4      35 ..      35      66 ..      32      72 .. 0.91

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.9e-06
  F-box-like  4 LPdEiLlqIFsyLppsdLlrlalVCrrWrrva 35
                 P E+ l+ Fsy+p +dL +l l ++r ++ +
  EFC37598.1 35 VPVEVKLHTFSYVPMKDLPNLLLISKRLKNSI 66
                59*************************98766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       293  (0.0163422); expected 358.6 (0.02)
Passed bias filter:                      233  (0.0129957); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.50
# Mc/sec: 713.83
//
Query:       EFC37599.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.82    9.7   4.8        0.3   11.1   0.7    2.3  3  DUF2393   Protein of unknown function (DUF2393)


Domain annotation for each model (and alignments):
>> DUF2393  Protein of unknown function (DUF2393)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.7   1.7e-05       0.3      15      64 ..       6      55 ..       2      59 .. 0.92
   2 ?   -1.9   0.0      0.17     3e+03      50      73 ..     118     141 ..     111     146 .. 0.74
   3 ?   -2.2   0.0      0.21   3.7e+03      97     124 ..     300     327 ..     285     330 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 1.7e-05
     DUF2393 15 savalfliflsllilflapfvvhliidkylkkaeltilsqkrllyteafv 64
                ++va+++i+l +li++ a+ v +l+ ++ +k+ +++  + +r+ y ++++
  EFC37599.1  6 KTVAFAVILLTFLITSCAASVKILTSTTRIKPDQIMEIDINRSGYVDQVI 55
                4579**************************************99998875 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.17
     DUF2393  50 tilsqkrllyteafvvdgtitNeG 73 
                  +l ++     ++++v+++ +N +
  EFC37599.1 118 LNLVYSGEELGKSYIVQVNLKNLT 141
                 556666666788999999999976 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.21
     DUF2393  97 ellkklkplvsksevikedlkpgeskeF 124
                   ++k++ + + +e++k +++ +e++++
  EFC37599.1 300 SDQAKVVCVNNNREIVKVPISSNEETNY 327
                 4566778888899999999999988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       583  (0.0325172); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.24s 00:00:00.76 Elapsed: 00:00:00.43
# Mc/sec: 2626.35
//
Query:       EFC37600.1  [L=292]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.9e-11   43.7   0.1    1.1e-10   42.3   0.1    1.8  2  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
        2.5    8.7   5.4         72    4.0   5.3    2.1  1  DUF3800         Protein of unknown function (DUF3800)


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.2   1.1e+04      83      93 ..      69      79 ..      29      82 .. 0.55
   2 !   42.3   0.1   1.2e-14   1.1e-10       2      91 ..     127     225 ..     126     232 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.2
                    .-SS-EEEEEE CS
  2OG-FeII_Oxy_3 83 tkggeRlsltg 93
                    t+ ++R+s+t+
      EFC37600.1 69 TEFTRRYSATI 79
                    22225666665 PP

  == domain 2  score: 42.3 bits;  conditional E-value: 1.2e-14
                     EEEEE-TT-EEEEE-SS--............--TT.-.EEEEEEEEE....ET-B--EEE............---TT-EEEEE-..B-TEEE--B CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfe............keegsgqrrltvllyLnekeseeGGelelyekdk..eavkikpkkgrlvlFesdellpHevlpv 82 
                      +++y+++q++ +H+D ++             ++ ++q  +t+l+yLn  + e+GGe +++++ +  e+ +ikp+ g+ v+F  + l  H+++ v
      EFC37600.1 127 RMYKYEKKQHFLKHFDGTNkrilsltegkkpVKQFTEQSFMTFLVYLN--DVEKGGETQFFDTYSkeETFDIKPEMGSGVVFLHELL--HQGNDV 217
                     56889999********999*********9997777799*********8..569*******999989999***************988..****** PP

                     .-SS-EEEE CS
  2OG-FeII_Oxy_3  83 tkggeRlsl 91 
                       gg ++ l
      EFC37600.1 218 -LGGVKYLL 225
                     .55699876 PP

>> DUF3800  Protein of unknown function (DUF3800)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   5.3    0.0081        72      44      88 ..     120     266 ..      34     289 .. 0.53

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.0081
     DUF3800  44 y.................................................................................................. 44 
                 +                                                                                                  
  EFC37600.1 120 Fsvsdkfrmykyekkqhflkhfdgtnkrilsltegkkpvkqfteqsfmtflvylndvekggetqffdtyskeetfdikpemgsgvvflhellhqgndvl 218
                 033333333333333334444444445555555555555555555555555566666666666666666666666666666666666666666666666 PP

     DUF3800  45 ...krlleriakflkkndlik.sdeesdesilivldkkkkkekakkel 88 
                    k+ll+    ++k++++ +  +++ ++ +++  d+kk+k++++++l
  EFC37600.1 219 ggvKYLLRTDICYMKQKEIVEdGQKNINYTMKVSADQKKNKNSQNNIL 266
                 666555555555555542222466667777777777777766666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (292 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 1997.11
//
Query:       EFC37601.1  [L=450]
Description: hypothetical protein NAEGRDRAFT_53605 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.2e-08   34.7   0.1    2.4e-08   33.7   0.1    1.5  1  F-box-like  F-box-like
    3.1e-05   23.7   0.4    0.00013   21.7   0.4    2.1  1  F-box       F-box domain
      0.004   17.5  36.5     0.0083   16.5   0.7    6.8  7  LRR_4       Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
      0.092   12.8   7.8         12    6.3   0.1    4.5  3  LRR_6       Leucine Rich repeat
       0.19   12.0   2.9        1.4    9.2   0.1    3.4  3  DUF4522     Protein of unknown function (DUF4522)


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.7   0.1   6.8e-12   2.4e-08       2      34 ..      20      53 ..      19      58 .. 0.88

  Alignments for each domain:
  == domain 1  score: 33.7 bits;  conditional E-value: 6.8e-12
  F-box-like  2 srLPdEiLlqIFsyLpps.dLlrlalVCrrWrrv 34
                ++LP+E Ll+IFs+L+ +  Ll l+lVC++W+ +
  EFC37601.1 20 DQLPTEMLLEIFSFLHSKfRLLTLSLVCKKWKFL 53
                78*************77779***********876 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.4   3.7e-08   0.00013       5      36 ..      21      53 ..      18      57 .. 0.93

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 3.7e-08
                HS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHH CS
       F-box  5 rLPsevlrhILerLplsd.llalrrVSkgwril 36
                +LP e l++I+++L  +  ll l++V+k+w+ l
  EFC37601.1 21 QLPTEMLLEIFSFLHSKFrLLTLSLVCKKWKFL 53
                7*****************************965 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.8    0.0012       4.3       2      37 ..     111     145 ..     110     153 .. 0.71
   2 !    6.7   3.8    0.0029        11       2      33 ..     133     170 ..     132     177 .. 0.79
   3 ?    0.6   0.2      0.23   8.3e+02      18      29 ..     213     223 ..     207     240 .. 0.64
   4 !    5.9   2.9    0.0053        19      14      41 ..     268     293 ..     255     299 .. 0.66
   5 ?    4.0   1.1     0.019        70      21      38 ..     328     344 ..     320     353 .. 0.67
   6 !    7.5   2.0    0.0016       5.8       3      29 ..     332     363 ..     330     367 .. 0.83
   7 !   16.5   0.7   2.3e-06    0.0083       1      33 [.     357     391 ..     357     397 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0012
                 S--EEE--SS---E-S-.HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpnLkeLdLsgNnlit 37 
                 +L++L +    + ++ + ++++ nLk+Ld+ +  +++
  EFC37601.1 111 SLQYLKCLV-PIDELRFiINQFSNLKSLDIRRS-KLS 145
                 666677776.78889996667********8333.443 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0029
                 S--EEE--SS---E-S-HH.......H-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdiplle.......klpnLkeLdLsgN 33 
                 nL++Ld++  +l+d + +        +lpnL eL + +N
  EFC37601.1 133 NLKSLDIRRSKLSDNSICHelmnsklSLPNLVELKI-EN 170
                 9*******77*******4446677778*********.44 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.23
                 -HHH-TT--EEE CS
       LRR_4  18 lleklpnLkeLd 29 
                  ++ l++L+ +d
  EFC37601.1 213 YPN-LKKLELID 223
                 344.55555544 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.0053
                 -E-S-HH..H-TT--EEE-.-S-----GGG CS
       LRR_4  14 tdiplle..klpnLkeLdLsgNnlitdlde 41 
                  d+++l+  +l+nLk+L +  N   +dl+ 
  EFC37601.1 268 DDVNFLQksNLKNLKKLKI-TN---QDLTF 293
                 4777777867*********.55...37664 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.019
                 H-TT--EEE-.-S----- CS
       LRR_4  21 klpnLkeLdLsgNnlitd 38 
                 +l+ L++Ld+ +N +i++
  EFC37601.1 328 NLDLLTSLDI-SNGKISS 344
                 4777888888.5545544 PP

  == domain 6  score: 7.5 bits;  conditional E-value: 0.0016
                 --EEE--SS---E-S-...HH..H-TT--EEE CS
       LRR_4   3 LevLdLsnNqltdipl...le..klpnLkeLd 29 
                 L++Ld+sn ++++ +    l+   ++nL++L 
  EFC37601.1 332 LTSLDISNGKISSNDVidlLNecEMKNLTKLK 363
                 99*****879***99977655866****9995 PP

  == domain 7  score: 16.5 bits;  conditional E-value: 2.3e-06
                 SS--EEE--SS---.E-S-.HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqlt.dipl.leklpnLkeLdLsgN 33 
                 +nL++L  +n+ l+ ++ + +ek+++Lk+LdLs N
  EFC37601.1 357 KNLTKLKAQNCSLSqEVIPiIEKMKSLKYLDLSLN 391
                 79************644445779*********545 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.2     0.011        41       3      18 ..     132     147 ..     132     149 .. 0.89
   2 ?    3.2   0.7     0.032   1.1e+02       5      21 ..     332     348 ..     331     351 .. 0.83
   3 ?    6.3   0.1    0.0033        12       3      14 ..     381     392 ..     379     397 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.011
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 ++L++Ld++  +++D 
  EFC37601.1 132 SNLKSLDIRRSKLSDN 147
                 68********999996 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.032
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt+Ld+s  +I+   ++
  EFC37601.1 332 LTSLDISNGKISSNDVI 348
                 9*******999977665 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0033
       LRR_6   3 thLteLdLsgNd 14 
                  +L++LdLs N 
  EFC37601.1 381 KSLKYLDLSLNS 392
                 58********96 PP

>> DUF4522  Protein of unknown function (DUF4522)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.2      0.29     1e+03      36      65 ..     197     226 ..     183     283 .. 0.79
   2 ?    0.1   0.1      0.26   9.5e+02      59      93 ..     254     288 ..     230     297 .. 0.76
   3 ?    9.2   0.1   0.00038       1.4      58      95 ..     331     368 ..     301     385 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.29
     DUF4522  36 ytnlaniklPfleeiaygsslklkksktvk 65 
                 y ++ +i+ P++ ++ y +  kl+  ++v 
  EFC37601.1 197 YGRMFKIRKPVVANLEYPNLKKLELIDVVI 226
                 778889999999999998888887766543 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.26
     DUF4522  59 kksktvkeellPsaesiklereyelkrlkklklqe 93 
                 ++s  + e  l ++++++  ++ +lk lkklk+ +
  EFC37601.1 254 SESLEKLEINLVTTDDVNFLQKSNLKNLKKLKITN 288
                 45555556777788888888888999999998876 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00038
     DUF4522  58 lkksktvkeellPsaesiklereyelkrlkklklqena 95 
                 l +s  + + ++ s++ i l  e e+k l+klk q+  
  EFC37601.1 331 LLTSLDISNGKISSNDVIDLLNECEMKNLTKLKAQNCS 368
                 5555566788999*********************9854 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (450 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      285  (0.015896); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.34s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 2527.79
//
Query:       EFC37602.1  [L=529]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.4e-13   48.1   3.4      1e-12   47.9   2.0    1.8  2  PI3Ka     Phosphoinositide 3-kinase family, accessory domain 
  ------ inclusion threshold ------
       0.03   14.2   0.2      0.074   13.0   0.0    1.7  2  PI3K_C2   Phosphoinositide 3-kinase C2


Domain annotation for each model (and alignments):
>> PI3Ka  Phosphoinositide 3-kinase family, accessory domain (PIK domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.9   2.0   1.1e-16     1e-12      49     166 ..     122     237 ..     114     253 .. 0.87
   2 ?   -2.4   0.0      0.29   2.6e+03     134     151 ..     334     351 ..     322     378 .. 0.85

  Alignments for each domain:
  == domain 1  score: 47.9 bits;  conditional E-value: 1.1e-16
                 HHHTTS-SSSHHHHHHHHHHHTTSHHTTHHHHTTTTSTTS--HHHHHHHHHHHHHSHHHHHHHHHHHHHHHHGGSSSSSSHHHHHHHHHHHHSHHHHHH CS
       PI3Ka  49 klLqsvkwseesevkealelldsWaeididdaLeLLdskfkdesvreyavkvLekasdeelllYllQLVqalkyepikdsalaefLlkralknkrlghf 147
                  +L+ + ++++    e  +l+ +W++ +i++ + LL+ +    +v++  ++ Le+++   l   l+ L+ ++k++  ++++l e+Llk ++k+k++g++
  EFC37602.1 122 PFLRRISFENQWVIYESRKLISQWEKPEIHEIVILLSGN-IGLFVKSLIIQLLEQVDHGLLTSLLPFLIHCVKFD-SVNGVLVEYLLKLSVKSKSIGNQ 218
                 57777778888878888999*********9988888776.689********************************.99********************* PP

                 HHHHHHHHHHCCTHHHHHH CS
       PI3Ka 148 ffWyLkseiedkevserfk 166
                 +fW Lk+e+  ++v++   
  EFC37602.1 219 LFWLLKTESIYHQVCKLTI 237
                 *********9999977544 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.29
                 HHHHHHHSHHHHHHHHHH CS
       PI3Ka 134 LlkralknkrlghfffWy 151
                 ++ r ++n  +ghf++ y
  EFC37602.1 334 IIGRDVNNTTIGHFVIGY 351
                 688999999****99865 PP

>> PI3K_C2  Phosphoinositide 3-kinase C2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   8.3e-06     0.074      29      98 ..       3      73 ..       1      97 [. 0.86
   2 ?   -3.0   0.0      0.71   6.4e+03      95     131 ..     422     457 ..     417     466 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 8.3e-06
                ETT.TTTEEEEEEEEEEECCCS-TTEEEEEEEEEEEECTC..EEE.-EEEEEEEESC-TTSCCGGCEEEEEE CS
     PI3K_C2 29 sfsfksikwnewltfpiqisdLPrsarLvitiwevkgkeks.eev.eplgwvnlsLFdkkgiLrqGkqkLkl 98
                +f  ++  wne +tf   is+++ +  + i++     ++ + + + +++ +++++ Fd+  +L qG   L+l
  EFC37602.1  3 PFT-ENLHWNEEITFNSLISEISCDYCIQISLIRFDLDSMTgTLSrREFLKCKCPVFDSSFQLYQGDLNLHL 73
                566.8999******************9999997777766666556699******************999988 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.71
                 EEEECCS-----SHH.SSSCHCCCCCCCHTTSSS-CC CS
     PI3K_C2  95 kLklwtsketdgsvetedelnrlekllkkyergqvek 131
                  Lkl+  + t+++  +  ++n+ ++ l+ky +  +ek
  EFC37602.1 422 MLKLYSLSYTKEFASK-RNQNKFDGWLTKYHDDFIEK 457
                 5666666666666665.55577777777776666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (529 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.28s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 3323.36
//
Query:       EFC37603.1  [L=586]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.9e-41  139.5   0.0    1.6e-40  138.3   0.0    1.7  1  Ras            Ras family
    2.7e-18   66.3   0.0    1.6e-17   63.8   0.0    2.2  2  Roc            Ras of Complex, Roc, domain of DAPkinase
    7.9e-12   45.0   1.1    8.2e-07   28.9   0.1    4.0  4  Kelch_4        Galactose oxidase, central domain
    2.1e-10   40.5   0.3    1.4e-08   34.7   0.0    3.6  4  Kelch_6        Kelch motif
    3.7e-09   36.4   2.2    0.00026   20.9   0.3    3.7  3  Kelch_5        Kelch motif
    1.4e-08   34.4   0.2    3.1e-06   26.9   0.0    3.1  3  Kelch_2        Kelch motif
    3.2e-07   29.8   0.5    5.5e-05   22.7   0.0    2.9  2  Kelch_1        Kelch motif
      3e-05   24.2   0.1     0.0011   19.1   0.0    3.3  3  Kelch_3        Galactose oxidase, central domain
    0.00066   19.5   0.7      0.002   18.0   0.7    1.8  1  F-box          F-box domain
  ------ inclusion threshold ------
      0.019   15.5   2.3       0.48   11.0   0.6    2.5  2  Elongin_A      RNA polymerase II transcription factor SIII (E
       0.09   12.9   0.1       0.18   11.9   0.1    1.4  1  vWA-TerF-like  vWA found in TerF C terminus


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  138.3   0.0     1e-43   1.6e-40       1     160 [.     390     562 ..     390     564 .. 0.96

  Alignments for each domain:
  == domain 1  score: 138.3 bits;  conditional E-value: 1e-43
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 K+v vGd+avGKt+l ++ +++ F++ey +T+ +d+y+++  +dg++ +l +wDTAG e++++lr+l+y +++ ++l ++ +s++s +nv  kw+ ei+
  EFC37603.1 390 KIVQVGDGAVGKTCLWISLTTNAFPHEYVPTV-FDNYSQNYVCDGTTFSLGLWDTAGPEDYDRLRPLSYPQTDLFFLSFSCSSESSMDNVVsKWIPEIR 487
                 89******************************.********************************************************988******* PP

                 HHSTTTSEEEEEEETTTGGG.............G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee.............kravsteegeelakelg.lkfletSAktnenveeafeellrei 160
                 ++++ +++++Lv +K+D ++             k+  s+e+ge lak++g l++letSA t  +++++ e ++r+i
  EFC37603.1 488 HHCP-TTAVALVCTKIDFRDdpvlsrellvkkhKKIHSFEQGELLAKKMGcLTYLETSALTGAGIKDLNEVMVRSI 562
                 ****.59*************************6666789***********99**************9999888876 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1         1   1.7e+03      28      81 ..     208     261 ..     198     312 .. 0.58
   2 !   63.8   0.0   9.8e-21   1.6e-17       1     119 [.     390     503 ..     390     504 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1
                 EETTTTEEEEEEECGGSGGCT..TBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSC CS
         Roc  28 ekstigvdfltkevtkikgve..ndkkvkkvklniWDtaGqerfrslhplylreaa 81 
                 e+s i+ +  ++   ki++ +  ++    +++++++D   ++++  l  ++++ ++
  EFC37603.1 208 EDSKIQETSQQT--DKIEKKQkkKQAGEPSFNIEVFDNVMNDDIFRLVLSFMTISD 261
                 333333332222..222222200222223466677776665555555555555555 PP

  == domain 2  score: 63.8 bits;  conditional E-value: 9.8e-21
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE..GHHH..HCH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd..srss..enl 95 
                 K+v vGd++vGKt+l  +++++ f +++ +t+  +++++ v  ++g       ++++l +WDtaG e+++ l+pl + + +l++l +   s+ss  + +
  EFC37603.1 390 KIVQVGDGAVGKTCLWISLTTNAFPHEYVPTVFDNYSQNYV--CDG-------TTFSLGLWDTAGPEDYDRLRPLSYPQTDLFFLSFScsSESSmdNVV 479
                 99******************************999987765..333.......5799****************************99864333231446 PP

                 HHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  96 keWlkelkkvagkspvilvgnkiD 119
                 ++W+ e++++++++ v lv++kiD
  EFC37603.1 480 SKWIPEIRHHCPTTAVALVCTKID 503
                 99*********************9 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   0.1     5e-10   8.2e-07       2      43 ..       5      45 ..       4      49 .. 0.86
   2 ?    3.9   0.0     0.033        54       1      32 [.      54      85 ..      54      97 .. 0.78
   3 !    8.1   0.0    0.0017       2.7       1      24 [.     113     139 ..     113     148 .. 0.88
   4 ?   -2.3   0.0       2.8   4.6e+03      16      23 ..     198     205 ..     196     208 .. 0.81

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 5e-10
     Kelch_4  2 RaghsatsipdgtiylfGGrgedgtllndlylldlstntWrr 43
                R g sat   ++++++fGG+ ++  ++n+l++++l++++W+ 
  EFC37603.1  5 RYGQSATIY-GDYLVVFGGYDNNSFTSNELFIFNLESREWKL 45
                555566666.69****************************86 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.033
     Kelch_4  1 pRaghsatsi.pdgtiylfGGrgedgtllndly 32
                +R +h+++ +   g+ y+ GG ++   l++d  
  EFC37603.1 54 GRYYHASVLDeETGDWYILGGKSAT-NLVKDFV 85
                599*******655********9986.5766655 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.0017
     Kelch_4   1 pRaghsatsi...pdgtiylfGGrged 24 
                 pR+ghs++     ++ ++y +GG++++
  EFC37603.1 113 PRFGHSLVLEkseNGKRLYSIGGCNNK 139
                 8*********764447*********86 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 2.8
     Kelch_4  16 ylfGGrge 23 
                 ++fGG + 
  EFC37603.1 198 FVFGGTYQ 205
                 79***986 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.7   0.0   8.6e-12   1.4e-08       1      43 [.       4      46 ..       4      52 .. 0.95
   2 ?   -0.5   0.0       1.1   1.7e+03      14      29 ..      69      83 ..      55      99 .. 0.65
   3 ?    0.3   0.0      0.62     1e+03       2      35 ..     114     152 ..     113     160 .. 0.58
   4 ?   -1.7   0.0       2.6   4.2e+03      15      23 ..     198     206 ..     198     224 .. 0.64

  Alignments for each domain:
  == domain 1  score: 34.7 bits;  conditional E-value: 8.6e-12
     Kelch_6  1 praghslvsvggkiYifGGytdsspylnkvwvydpetksWeql 43
                pr+g s++++g+++++fGGy++ s ++n ++++++e++ W+ +
  EFC37603.1  4 PRYGQSATIYGDYLVVFGGYDNNSFTSNELFIFNLESREWKLI 46
                68999***************999*****************987 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.1
     Kelch_6 14 iYifGGytdsspylnk 29
                 Yi+GG ++ ++ +++
  EFC37603.1 69 WYILGGKSA-TNLVKD 83
                599999988.555555 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.62
     Kelch_6   2 raghslvs.vg..g.kiYifGGytdsspylnkvwv.ydp 35 
                 r ghslv+     g ++Y +GG ++   +l+++++ ++ 
  EFC37603.1 114 RFGHSLVLeKSenGkRLYSIGGCNNKVDHLDCIYIdLNN 152
                 5677777742232258*****977755555555555555 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 2.6
     Kelch_6  15 YifGGytds 23 
                 ++fGG ++ 
  EFC37603.1 198 FVFGGTYQK 206
                 699**9984 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.3   1.6e-07   0.00026       4      41 ..       4      40 ..       3      41 .. 0.90
   2 !   10.8   0.0   0.00023      0.38       5      25 ..      55      77 ..      54      84 .. 0.86
   3 ?    1.8   0.0      0.15   2.5e+02       4      22 ..     113     135 ..     112     147 .. 0.76

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 1.6e-07
     Kelch_5  4 pRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdlps 41
                pR+g +a ++++++ v+GG++ +++  s+++++++l+s
  EFC37603.1  4 PRYGQSATIYGDYLVVFGGYD-NNSFTSNELFIFNLES 40
                89999999*************.677778*******987 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00023
     Kelch_5  5 Raghcavtvs..ekiYvyGGkvg 25
                R++h++v ++  + +Y+ GGk++
  EFC37603.1 55 RYYHASVLDEetGDWYILGGKSA 77
                9********97888*******97 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.15
     Kelch_5   4 pRaghcavtv.s...ekiYvyGG 22 
                 pR+gh+ v   s     +Y +GG
  EFC37603.1 113 PRFGHSLVLEkSengKRLYSIGG 135
                 9*******994233355998888 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   0.0   1.9e-09   3.1e-06       1      44 [.       4      45 ..       4      49 .. 0.96
   2 ?   -3.3   0.0       6.6   1.1e+04      34      45 ..      61      72 ..      60      75 .. 0.77
   3 ?    4.2   0.0     0.029        48       1      24 [.     113     137 ..     113     165 .. 0.82

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 1.9e-09
     Kelch_2  1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44
                +r+g+s++  g+ ++v+GG+  dn++  s+ + +++le+++W++
  EFC37603.1  4 PRYGQSATIYGDYLVVFGGY--DNNSFTSNELFIFNLESREWKL 45
                7*******************..********************97 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 6.6
     Kelch_2 34 vldlekhvWeev 45
                vld+e+  W  +
  EFC37603.1 61 VLDEETGDWYIL 72
                689999999765 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.029
     Kelch_2   1 rrgghsssvp....ggkiyvvGGahtdn 24 
                 +r+ghs +      g ++y++GG    n
  EFC37603.1 113 PRFGHSLVLEksenGKRLYSIGGC---N 137
                 6888999888888899*******9...3 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   3.4e-08   5.5e-05       1      40 [.       4      44 ..       4      46 .. 0.95
   2 ?    4.2   0.1     0.021        33      12      30 ..     128     147 ..     126     151 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 3.4e-08
                BBBSEEEEEETTEEEEEEEBCS.SSBEEEEEEEETTTTEEE CS
     Kelch_1  1 aragagavvvggkiYviGGsdg.gnalssvevyDpetntWr 40
                +r+g +a+  g+++ v+GG+d+ +  ++ ++++++e+ +W 
  EFC37603.1  4 PRYGQSATIYGDYLVVFGGYDNnSFTSNELFIFNLESREWK 44
                799*******************999999************7 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.021
                 TEEEEEEEBCS.SSBEEEEE CS
     Kelch_1  12 gkiYviGGsdg.gnalssve 30 
                  ++Y iGG+++    l++++
  EFC37603.1 128 KRLYSIGGCNNkVDHLDCIY 147
                 589*******9777776665 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0     7e-07    0.0011       1      47 [.      14      61 ..      14      63 .. 0.79
   2 ?   -0.4   0.0      0.97   1.6e+03       5      46 ..      70     119 ..      67     121 .. 0.60
   3 ?   -0.0   0.0      0.72   1.2e+03       1      14 [.     127     138 ..     127     160 .. 0.78

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 7e-07
     Kelch_3  1 gdrlyifGGlgddgqdrl.ndvyvydldtntWaei..aslppaRaghaat 47
                gd+l++fGG++  ++ ++ n+++ ++l++ +W+ i  +    +R++ha++
  EFC37603.1 14 GDYLVVFGGYD--NNSFTsNELFIFNLESREWKLIelSVEIKGRYYHASV 61
                89*********..555555**************66445555588888776 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.97
     Kelch_3   5 yifGGlgddgqdrlndvyvydldtntWa..ei......aslpp..aRaghaa 46 
                 yi GG+    ++ ++d+  + l+t  ++  ++      ++l +  +R gh++
  EFC37603.1  70 YILGGKS--ATNLVKDFVKIKLSTLDVDkaTCqsevliSELDGfaPRFGHSL 119
                 8889999..7888888888777776444321122234455555557777765 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.72
     Kelch_3   1 gdrlyifGGlgddg 14 
                 g rly +GG++  +
  EFC37603.1 127 GKRLYSIGGCN--N 138
                 679*******9..4 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.7   1.2e-06     0.002       7      36 ..     246     275 ..     244     276 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.2e-06
                 -HHHHHHHHHTS-HHHHHHHCTT-HHHHHH CS
       F-box   7 PsevlrhILerLplsdllalrrVSkgwril 36 
                  +++ r +L+++  sdl+ l +VSk++ri+
  EFC37603.1 246 NDDIFRLVLSFMTISDLCKLELVSKKLRIC 275
                 6899************************98 PP

>> Elongin_A  RNA polymerase II transcription factor SIII (Elongin) subunit A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.064     1e+02      70      98 ..     203     231 ..     159     235 .. 0.84
   2 ?   11.0   0.6   0.00029      0.48       8     104 ..     246     356 ..     243     357 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.064
   Elongin_A  70 lYeklkkereeklkeaaerLreaykklkk 98 
                  Y+k+++++ +++ +++++++++ kk+++
  EFC37603.1 203 TYQKTEDSKIQETSQQTDKIEKKQKKKQA 231
                 68899999999999999999998888876 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00029
   Elongin_A   8 pyellrpiLekctpeqLreiEensphla....eetdelWkklikrdfpeesk.ekste.........pkep..kswrelYeklkkereeklkeaaerLr 90 
                 + ++ r +L  +t+  L ++E  s++l        d+ Wk  + + +  + +  k+++            +   +++e+Y  + k + + +++  e + 
  EFC37603.1 246 NDDIFRLVLSFMTISDLCKLELVSKKLRicklTSEDQYWKDYYYQRINLYLEaSKTYNynynkitraY--EtnYQYSEIYTSYLKFTSNYKRRLIEVIG 342
                 6678899********************98877779********9988877664444445455554443..04589999999999999999999888888 PP

   Elongin_A  91 eaykklkkekekkk 104
                 e + k++++ +k++
  EFC37603.1 343 ECMSKADRDHHKRT 356
                 88888888888775 PP

>> vWA-TerF-like  vWA found in TerF C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   0.00011      0.18      11      95 ..     162     246 ..     158     273 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
  vWA-TerF-like  11 sgSmsklykkgvvqavverllavaa.qlDddgelevwlfaskakrlpdvtladleeyvkeeeegllelkklggvneeapvleevle 95 
                    + S+s+++k++ v  v    ++  + + Dd  +++ ++f+ ++++++d +++++++ +++ e+++ + k++g+   + +v ++v++
     EFC37603.1 162 THSLSHTFKSKDVGPVFHANVPFQViNEDDSIAMNYFVFGGTYQKTEDSKIQETSQQTDKIEKKQ-KKKQAGEPSFNIEVFDNVMN 246
                    6799999**********9999997625677779*************************8877765.55566665666666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (586 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1049  (0.0585086); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.68u 0.28s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 3704.37
//
Query:       EFC37604.1  [L=702]
Description: chromate ion transporter [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.2e-64  215.1  30.6      1e-42  145.9   6.0    2.8  3  Chromate_transp  Chromate transporter
  ------ inclusion threshold ------
      0.041   12.9   0.0      0.091   11.8   0.0    1.5  1  DUF808           Protein of unknown function (DUF808)
      0.073   12.7   0.1       0.25   11.0   0.1    1.9  1  MOZART2          Mitotic-spindle organizing gamma-tubulin rin
       0.12   12.0   2.6        3.1    7.4   0.1    3.6  3  CPP1-like        Protein CHAPERONE-LIKE PROTEIN OF POR1-like
       0.16   11.8   1.7        0.4   10.5   0.0    2.3  2  YlaC             Inner membrane protein YlaC
        0.2   11.9   0.0       0.54   10.5   0.0    1.6  1  PBP_N            Penicillin-binding protein N-terminus
       0.51   10.7   9.8        6.2    7.3   0.2    3.8  4  PBP1_TM          Transmembrane domain of transglycosylase PBP
       0.95    9.8   0.0       0.95    9.8   0.0    3.2  4  Orf78            Orf78 (ac78)
        8.2    7.6   9.4         27    6.0   5.0    2.6  2  DUF3484          Membrane-attachment and polymerisation-promo


Domain annotation for each model (and alignments):
>> Chromate_transp  Chromate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.6  10.7   1.4e-25   2.8e-22       5     154 ..     163     323 ..     160     330 .. 0.83
   2 ?   -1.4   0.3       1.2   2.3e+03      75     103 ..     434     461 ..     426     470 .. 0.68
   3 !  145.9   6.0   5.1e-46     1e-42       3     154 ..     475     689 ..     473     692 .. 0.89

  Alignments for each domain:
  == domain 1  score: 79.6 bits;  conditional E-value: 1.4e-25
  Chromate_transp   5 lfflkiGllifGGgyavipllreevverkgwlteeefldglalaqalPGPiavnlatfvGylil.gvlGaliatlgfflPsfllilllapllek 97 
                       +fl +Gl++f Gg   i+++++++v++k+wlte+ef++++al+q+lPG+i+ ++++ +++l + g++ +++a l+f+ P+f+  ll+ +l+  
       EFC37604.1 163 TVFLPLGLTTFVGG---IQIVQKKFVDKKKWLTEAEFMEIYALSQSLPGAIISQVVFSIAML-RhGFWSGFLANLLFCGPGFIANLLFGWLMAD 252
                      689********996...7789******999********************************.55***************************** PP

  Chromate_transp  98 lrk..n..plvkaaleglnaavvglilaaalslakk..........iallaflllllfkvspilvillaal 154
                      ++   n  ++v ++ +gl +  +++ ++ a+++a+           ++l++f+++l++  +p++++ + ++
       EFC37604.1 253 ISIddNspRWVLNLQNGLACSGIAFAVSSAFRMASMlnksksrafsFILAGFVAMLTMVAKPMWILPILIF 323
                      6435544588*********************6655566789999997788888888774445444433222 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.2
  Chromate_transp  75 iatlgfflPsfllilllaplleklrknpl 103
                      i++l++f+  f+++++ + ++e++ k+p+
       EFC37604.1 434 ISMLLIFALLFVVLIVTSVIFETY-KKPT 461
                      456677777777777777777777.4444 PP

  == domain 3  score: 145.9 bits;  conditional E-value: 5.1e-46
  Chromate_transp   3 lflfflkiGllifGGgyavipllreevverkgwlteeefldglalaqalPGPiavnlatfvGylilgvlG........................ 72 
                      +++ff+k+G+lifGGg++ ipllr+e+verk w+te++f++g+++++al GP + ++a+f+G++ +   G                        
       EFC37604.1 475 MSNFFYKYGTLIFGGGVGGIPLLRNEMVERK-WVTEQQFMNGFSISNALVGPKH-SVAAFYGAC-I---Gakfaealvnsgsnrtingtylnet 562
                      899**************************66.*********************9.*********.4...2233467888889999999999999 PP

  Chromate_transp  73 ...................................aliatlgfflPsfllilllaplleklrknplvkaaleglnaavvglilaaalslakk.. 129
                                                         ++ia+l+f+lP++l++++++pl++k+r+n+++k +l g+na++vg+++++ +s++    
       EFC37604.1 563 lifgnetnsnnftnpnqirvkqrssalyyilppllGVIAGLLFHLPGYLTMAGCLPLWRKIRENNVIKLSLIGVNAVCVGFVVSNSISMWIDnv 656
                      9999*********************************************************99************************8755588 PP

  Chromate_transp 130 .......iallaflllllfkvs.pilvillaal 154
                             +a++ ++l+++f++s pi+vi++a+l
       EFC37604.1 657 gtssylaAATIFCFLMNFFDFSpPIIVIAGAIL 689
                      8899998556667799999***55666666655 PP

>> DUF808  Protein of unknown function (DUF808)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   4.6e-05     0.091      80     140 ..     305     364 ..     279     375 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.6e-05
      DUF808  80 aalllsafapwlitplLmlGgayLcfEGaeKvlekllhkeeeeeeeeeeaeeadlaelEke 140
                 +a+l  +  p+ i p+L++Gga++++  +  ++++++ + ++ e ++++a+++d +e E+e
  EFC37604.1 305 VAMLTMVAKPMWILPILIFGGAFVSYF-FSLIYDRIMSRIDKYEIRKQAAQKKDNEEDEEE 364
                 5777778889***************95.566777775444443434444444444433333 PP

>> MOZART2  Mitotic-spindle organizing gamma-tubulin ring associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   0.00013      0.25      15      51 ..     180     218 ..     171     221 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00013
     MOZART2  15 vqkyav.kkkkvLsaeeaeLyeLtq.aaGiviDqevfki 51 
                 vqk  v kkk + +ae +e+y L+q + G+ i q vf i
  EFC37604.1 180 VQKKFVdKKKWLTEAEFMEIYALSQsLPGAIISQVVFSI 218
                 66555505555667999******99458*********88 PP

>> CPP1-like  Protein CHAPERONE-LIKE PROTEIN OF POR1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.15     3e+02      74     160 ..     145     229 ..     126     247 .. 0.76
   2 ?    0.7   0.1      0.18   3.5e+02      72     113 ..     408     449 ..     385     466 .. 0.52
   3 ?    7.4   0.1    0.0015       3.1     135     189 ..     622     670 ..     540     676 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.15
   CPP1-like  74 lkkspawvkklqesldtPssedlliraavflvlavltlvapaesvpalllalglgasiyflnrKek.klgravlltlvgLvvGlllGs 160
                  k+  +w k+l ++++   + ++ +++++ ++++++ +v+++    + +l+ + ++ iy l +     ++  v++++++L  G+  G 
  EFC37604.1 145 RKNQEQW-KWLWNMIKE--TVTVFLPLGLTTFVGGIQIVQKKFVDKKKWLTEAEFMEIYALSQSLPgAIISQVVFSIAMLRHGFWSGF 229
                 2233456.678888874..678899999999********9999999999999999999999987653777778899999998887664 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.18
   CPP1-like  72 sklkk..spawvkklqesldtPssedlliraavflvlavltlva 113
                 +++++  +p    k+++++ t s+  l i++++  +l+ ++l++
  EFC37604.1 408 EETQEkrKP--KDKFSKNVRTHSPLWLGISMLLIFALLFVVLIV 449
                 222222355..346777777777776666655444444443333 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0015
   CPP1-like 135 nrKekklgravlltlvgLvvGlllGsllasllqvdvalsglsseellvslvtlvl 189
                 + +e+++++  l+++ + +vG+++++ ++ ++ + v  s     + l++++++++
  EFC37604.1 622 KIRENNVIKLSLIGVNAVCVGFVVSNSISMWIDN-VGTS-----SYLAAATIFCF 670
                 458999**************************66.4333.....22333333333 PP

>> YlaC  Inner membrane protein YlaC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0    0.0002       0.4      17      59 ..     410     453 ..     402     479 .. 0.81
   2 ?   -1.2   0.4      0.83   1.7e+03      41      76 ..     638     674 ..     626     679 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.0002
        YlaC  17 keekrdnkvrfsskfikkhp.ylflamlvsylavavlllyspyl 59 
                 ++ekr  k +fs++  ++ p +l ++ml+ ++++ v+l++++++
  EFC37604.1 410 TQEKRKPKDKFSKNVRTHSPlWLGISMLLIFALLFVVLIVTSVI 453
                 79**********9875555547889******9999888877654 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.83
        YlaC  41 amlvsylavavlllyspylgl.aslilltvllillsa 76 
                 a+ v++++   + +  + +g+ ++l++ t++  l++ 
  EFC37604.1 638 AVCVGFVVSNSISMWIDNVGTsSYLAAATIFCFLMNF 674
                 6778888877665555555551556666666666653 PP

>> PBP_N  Penicillin-binding protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00027      0.54      61     114 ..     130     187 ..     109     205 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00027
       PBP_N  61 epeepfradlkha.aakkkarkgrwvwg....tllvvvllavlsvasgaayvwfkylkd 114
                 e  e fr  lk+  + +k+  +++w+w     t+ v + l++ +  +g   v  k++  
  EFC37604.1 130 EQAELFRE-LKQDrKERKNQEQWKWLWNmikeTVTVFLPLGLTTFVGGIQIVQKKFVDK 187
                 56677875.5555055666789*****73333556666689999999999998888765 PP

>> PBP1_TM  Transmembrane domain of transglycosylase PBP1 at N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       4.7   9.4e+03      43      69 ..       5      32 ..       2      36 .. 0.42
   2 ?    7.3   0.2    0.0031       6.2      56      79 ..     138     161 ..     101     166 .. 0.74
   3 ?    2.0   0.6      0.14   2.8e+02      33      58 ..     344     370 ..     337     374 .. 0.61
   4 ?    5.4   0.0     0.012        24      46      84 ..     397     442 ..     389     447 .. 0.54

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 4.7
     PBP1_TM 43 edDdddddeeeevprk.gkkkkpprkkr 69
                ++D d+++   + +   + ++ +pr k+
  EFC37604.1  5 NNDSDKNKTTTKTTESpNGNATSPRIKQ 32
                3444433333333332433344466555 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0031
     PBP1_TM  56 prkgkkkkpprkkrrwlwlliklf 79 
                  ++ +k+++++++++wlw +ik  
  EFC37604.1 138 LKQDRKERKNQEQWKWLWNMIKET 161
                 3447888889999********955 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.14
     PBP1_TM  33 ddydd.eyddeedDdddddeeeevprk 58 
                 d y+  +   +++D+++d+ee  ++ k
  EFC37604.1 344 DKYEIrKQAAQKKDNEEDEEETSLTIK 370
                 566653334456677777777776666 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.012
     PBP1_TM  46 dddddeeeevprkgkkkkpprkkrr......w.lwlliklflvlvv 84 
                 ++ + e ++v   +++k++p+ k +        lwl i ++l++++
  EFC37604.1 397 QEPQAETQTVVEETQEKRKPKDKFSknvrthSpLWLGISMLLIFAL 442
                 2233444444444444444444433333333359999999999986 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   1.6       2.6   5.3e+03      29      47 ..       4      22 ..       1      45 [. 0.43
   2 ?   -3.7   0.0       7.8   1.6e+04      51      66 ..     142     157 ..     125     167 .. 0.44
   3 ?   -1.7   0.0       1.8   3.5e+03      44      58 ..     353     366 ..     334     387 .. 0.48
   4 ?    9.8   0.0   0.00048      0.95      31      83 ..     394     449 ..     380     465 .. 0.48

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.6
       Orf78 29 ddndkaenkkekksaaekn 47
                ++nd+++nk+++k++++ n
  EFC37604.1  4 SNNDSDKNKTTTKTTESPN 22
                3333333333332222222 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 7.8
       Orf78  51 ekesnaaekaqalnil 66 
                  ke++++e+ + l ++
  EFC37604.1 142 RKERKNQEQWKWLWNM 157
                 1222223333333333 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.8
       Orf78  44 aeknditekesnaae 58 
                 a+k+d +e+e++ ++
  EFC37604.1 353 AQKKDNEEDEEE-TS 366
                 112221111111.11 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00048
       Orf78  31 ndkaenkkekksaa.eknditekesn..aaekaqalnillisllavvcvlvllyvi 83 
                 +d++e ++e++++  e+++ ++ +++  ++ ++++   l is+l ++++l ++ ++
  EFC37604.1 394 QDNQEPQAETQTVVeETQEKRKPKDKfsKNVRTHSPLWLGISMLLIFALLFVVLIV 449
                 22222223333333033333333333223444455555566677777666655554 PP

>> DUF3484  Membrane-attachment and polymerisation-promoting switch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1      0.12   2.3e+02      36      66 ..     350     379 ..     340     379 .. 0.80
   2 ?    6.0   5.0     0.014        27      19      59 ..     388     425 ..     382     426 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.12
     DUF3484  36 eqPvpskeqeekepkkekltdrvkglFgnmF 66 
                 +q++++k++ee e ++  lt + k +F ++F
  EFC37604.1 350 KQAAQKKDNEEDEEET-SLTIKQKIIFVYLF 379
                 5666678888888788.**********9999 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.014
     DUF3484  19 PvdpqvqenpqvqeqaqeqPvpskeqeekepkkekltdrvk 59 
                 Pv+  ++++++ ++qa++q v +++qe+ +pk+ k+   v+
  EFC37604.1 388 PVE--PAQQDNQEPQAETQTVVEETQEKRKPKD-KFSKNVR 425
                 555..233444556766666646999*****99.9988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (702 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1360  (0.0758548); expected 358.6 (0.02)
Passed bias filter:                      555  (0.0309554); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.74u 0.34s 00:00:01.08 Elapsed: 00:00:00.49
# Mc/sec: 4279.54
//
Query:       EFC37605.1  [L=2295]
Description: dead box RNA helicase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     6e-140  464.7  12.8    5.3e-78  261.7   1.8    2.6  2  Sec63         Sec63 Brl domain
    4.4e-49  166.6   4.0      4e-25   88.6   0.8    3.6  3  DEAD          DEAD/DEAH box helicase
    9.5e-28   97.3   3.5    8.8e-14   51.9   0.1    3.3  3  ResIII        Type III restriction enzyme, res subunit
    8.8e-15   55.0   0.6    1.1e-06   28.9   0.0    5.1  4  Helicase_C    Helicase conserved C-terminal domain
    1.1e-06   29.0   1.4      0.026   14.8   0.1    4.0  3  AAA_22        AAA domain
    6.4e-06   26.6   1.0     0.0031   17.8   0.5    3.0  2  AAA_19        AAA domain
    1.9e-05   25.1   0.9      0.043   14.2   0.4    3.7  2  AAA           ATPase family associated with various cellular 
    0.00046   19.7   0.1       0.22   10.9   0.0    2.5  2  PhoH          PhoH-like protein
     0.0069   16.6   0.1       0.04   14.1   0.1    2.4  1  Helicase_PWI  N-terminal helicase PWI domain
  ------ inclusion threshold ------
      0.086   12.4   1.5       0.24   11.0   1.5    1.8  1  Rpn9_C        Rpn9 C-terminal helix
        0.1   12.3   0.1        5.4    6.7   0.0    3.0  3  IstB_IS21     IstB-like ATP binding protein
       0.37   10.5   5.9       0.94    9.2   0.0    3.9  4  AAA_11        AAA domain


Domain annotation for each model (and alignments):
>> Sec63  Sec63 Brl domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  261.7   1.8   3.5e-81   5.3e-78       1     256 [.    1073    1389 ..    1073    1390 .. 0.96
   2 !  207.7   3.7   1.1e-64   1.6e-61       1     255 [.    1957    2287 ..    1957    2289 .. 0.92

  Alignments for each domain:
  == domain 1  score: 261.7 bits;  conditional E-value: 3.5e-81
                  ECHHHHHHHHHT--HHHHHHHHHHS-TT--HHHHHHHHHTSGGGGGS---TTHHHHHHHHHHTSSS--SSSTTSHHHHHHHHHHHHHTT---SSHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       Sec63    1 ptelGriaShYyisyetiklfneslkpnttlkdlLeilssasEFeeipvReeEkkelkkLlekvpikvkediespeaKvniLlqayisrlklegsdl 97  
                  +t+lGriaSh+yi yeti+l+ne+l+p+++++d+L+i++sa EF++i+vRe+E +el++L  ++p+kv +  ++ + Kvn+L+q+yis +k+++s+l
  EFC37605.1 1073 ATDLGRIASHFYIHYETIQLYNEKLHPKMSESDVLHIVASAREFKNIKVREDESEELAELSANAPVKVTKGQDEFTGKVNLLIQSYISHVKIKNSSL 1169
                  59*******************************************************************999************************* PP

                  HHHHHHHHHHHHHHHHHHHHHHHHTTBHHHHHHHHHHHHHHHHTS-TT................................................. CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................................................. RF
       Sec63   98 vsDlkyilqnairilralveillskgwlslalslleLskmveqrlwds................................................. 145 
                  +sD ++i+q+++ri+ra++ei+++++w+sl+ +ll+L k++e+r+w +                                                 
  EFC37605.1 1170 ISDCAFIIQSVGRIIRAIFEIAIKERWSSLVDKLLTLTKCMERRQWVFehplrqmskiptfalqklenknltlsklveyeeseldqvlnvrgmgrii 1266
                  **********************************************8889*********************************************** PP

                  ......S--EEEEEEECEBTTSEEEEEEEEEESSSS-SCTSSS-CH..TSBEEEEEEEEETTTTEEEEEEEEEESSTTTTT..EEEEE......... CS
                  ......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxx......... RF
       Sec63  146 ......lPkleieaevqpitrsklrvevtiereeeeskpdfpwdkk..gksekfwlvvedsendellaikrvtlekkklas..tqevk......... 223 
                        +P+l++ea+vqpitr++lr++v+i+       p+f+wdkk  g++e++w++ved++++ ++++++++l+++++++  ++  +         
  EFC37605.1 1267 mehidrFPHLDLEANVQPITRNVLRFQVKIR-------PNFTWDKKlhGETEPWWIWVEDENSEFIYHSEYFLLKHDEYEKmmKE--Srddeegpcy 1354
                  *******************************.......************************************99988885322..246999**** PP

                  .EEEEEE-.SS.CCEEEEEEEEESSSSS-EEEEEE CS
                  .xxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxx RF
       Sec63  224 .leftvplsep.gpkqltvrlisdswlgldqevti 256 
                   l+f vp+ e  +p  + +r++sd+w+ ++ ++t+
  EFC37605.1 1355 sLNFVVPFREDpRPLYFIIRAVSDKWISAEAQITV 1389
                  *******9876155555689***********9987 PP

  == domain 2  score: 207.7 bits;  conditional E-value: 1.1e-64
                  ECHHHHHHHHHT--HHHHHHHHHHS-TT--HHHHHHHHHTSGGGGGS---TTHHHHHHHHHHTSSS--S.SSTTSHHHHHHHHHHHHHTT---SSHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       Sec63    1 ptelGriaShYyisyetiklfneslkpnttlkdlLeilssasEFeeipvReeEkkelkkLlekvpikvk.ediespeaKvniLlqayisrlklegsd 96  
                  pt  G iaS Yy+sy+t ++fn+ +k++++   lLe+l++a+EF eipvR++E+k +k+L e vp+ v  +d+esp+ K ++Llqa++ r+kl+ +d
  EFC37605.1 1957 PTATGIIASFYYLSYRTASHFNRLIKADSNVNYLLELLCEAKEFAEIPVRHNEDKLNKELSEVVPLGVYmHDYESPHIKCYLLLQAHFERVKLPIVD 2053
                  7999****************************************************************88*************************** PP

                  HHHHHHHHHHHHHHHHHHHHHHHHHTTBHHHHHHHHHHHHHHHHTS-TT................................................ CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................................................ RF
       Sec63   97 lvsDlkyilqnairilralveillskgwlslalslleLskmveqrlwds................................................ 145 
                  +++D+ +il++ iri +  ++i+++kg+l+++++++++ +m++q++w +                                                
  EFC37605.1 2054 YITDTRTILDSTIRISQSYIDICAEKGYLQPTINMMHILQMIMQARWATdstlyqlfsnlqcprentesssedihnfiqnlaqkenvtglkqlldvk 2150
                  ***********************************************8889********************************************** PP

                  ...............................S--EEEEEEE..CEBTTSEEEEEEEEEESSS.S-S...CTSSS-CHTSBEEEEEEEEETTTTEEEE CS
                  ...............................xxxxxxxxxx..xxxxxxxxxxxxxxxxxxx.xxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       Sec63  146 ...............................lPkleieaev..qpitrsklrvevtiereee.esk...pdfpwdkkgksekfwlvvedsendella 205 
                                                 +P l+++++       + +l+v+v+ier ++ +++   p ++++k    e+fwl+v++++n+ella
  EFC37605.1 2151 yqqgesalqkliskylrknnlvsnlmkiveeFPYLTVKIDKvtHDEEDHQLEVSVNIERLSKpKEQaytPMYTKQK---DEGFWLIVSNPQNNELLA 2244
                  *************************************887733334455666777777777774445889999999...****************** PP

                  EEEEEESSTTTTTEEEEEEEEEEE-.SSCCEEEEEEEEESSSSS-EEEEE CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       Sec63  206 ikrvtlekkklastqevkleftvplsepgpkqltvrlisdswlgldqevt 255 
                  +krv  ++k  ++      e+++p+se   k+l   ++ d++lgld + +
  EFC37605.1 2245 LKRVRANRK-FNR-----TEVYLPVSEN-DKELEAIVVPDCYLGLDVSSK 2287
                  ***999775.332.....4666655555.89**************98765 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1      0.38   5.7e+02     123     174 ..     279     336 ..     185     337 .. 0.69
   2 !   88.6   0.8   2.7e-28     4e-25       2     171 ..     572     745 ..     571     750 .. 0.84
   3 !   76.0   0.0   1.9e-24   2.9e-21       2     169 ..    1436    1600 ..    1435    1606 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.38
                 EEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTTSTTT.....SEEEEEESSBS.HHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxx.xxxx RF
        DEAD 123 rflVlDEadrlldqgfsdfinrilnqlpqitcdgklq.....rqvivlSATlp.kdvk 174
                 + lV+DE  ++ + +     ++++nq+++i+   ++q      q+ ++S T+p ++v+
  EFC37605.1 279 EALVIDENIEFGSADDITNADHLHNQFRNISIFSRSQlenvlDQTNLFSFTAPtENVE 336
                 679***********99999999999999887666655555666688888888877776 PP

  == domain 2  score: 88.6 bits;  conditional E-value: 2.7e-28
                 HHHHHHHHHHH.TTCEEEEEESTTSSHHHHHHHHHHHHHHHS.....TTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHH CS
                 xxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   2 diQaeaiplil.gggdvlvaaeTGsGKTlaflipvlqivyet.....kgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskl 94 
                 ++Q+ ++  ++ + +++lv+a+TG GKT ++++ vl+++ ++      ++++ k+++++P+++La ++++n++k++ +++++v+ ++g+ +    ++++
  EFC37605.1 572 RVQSDVFYSAYkTSENMLVCAPTGCGKTNIAMMTVLREIGQHfkggkIRREEFKIIYIAPMKALAAEMVENFSKRLAPLGITVKEMTGDMQL--TKREV 668
                 678888888884557************************88899996589999*************************99999866664433..45555 PP

                 HTTCSEEEEEHHHHHHHH...HCTSSH...CTTEEEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTTSTTTSEEEEEESSBSH CS
                 xxxxxxxxxxxxxxxxxx...xxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  95 dngvdivvgtpgrlddll...stgkln...lsqvrflVlDEadrlldqgfsdfinrilnqlpqitcdgklqrqvivlSATlpk 171
                  ++++++v+tp+++d  +   s    +   ++  r++++DE++ l ++ +++ i++i++++ ++ +++++  +++ lSATlp+
  EFC37605.1 669 -QQTQMIVTTPEKWDVTTrkaS----DqalIQLTRLIIIDEVHLLNED-RGPVIESIVARTLRQVETTQSMIRLVGLSATLPN 745
                 .689***********9775432....12336666*********99998.********9999888888888889********94 PP

  == domain 3  score: 76.0 bits;  conditional E-value: 1.9e-24
                  HHHHHHHHHHH.TTCEEEEEESTTSSHHHHHHHHHHHHHHHSTTSTS-EEEEEESSHHHHHHHHHHH.HHHTTTSTSEEEEEETTSSHHHHHHHHHT CS
                  xxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD    2 diQaeaiplil.gggdvlvaaeTGsGKTlaflipvlqivyetkgktgpkalivePtreLaeqtlnnl.kkfkkyidlrvlliiggvaardqlskldn 96  
                  ++Q ++++ ++ +++++l+ a+TGsGKTla+ + +++ +   ++k++ k+++++P+++L+++ l ++ kkf ++++ +++ ++g +  + +++ l +
  EFC37605.1 1436 PVQTQIFHMTYhTDENILIGAPTGSGKTLAAELCIFRLF---NTKPNQKVIYIAPLKALVRERLVEWeKKFVQKLGKKMVELTG-D-FTPDVKLL-K 1526
                  8999***99996668*********************887...589999*************99999946677779866665555.3.45788999.9 PP

                  TCSEEEEEHHHHHHHH..HCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTTSTTTSEEEEEESSB CS
                  xxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   97 gvdivvgtpgrlddll..stgklnlsqvrflVlDEadrlldqgfsdfinrilnqlpqitcdgklqrqvivlSATl 169 
                  ++div++tp+++d +   ++++  +++v ++V+DE++ l + g++  ++ i ++++ i+ +++ + +++ lS  +
  EFC37605.1 1527 EADIVITTPEKWDGISrnWQNRSYVRDVGLIVMDEIHLLGS-GRGAILEVITSRMRYISWNTQTHIRLMGLSTNM 1600
                  9*************9877444445*************9999.5************99999988888888888655 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   0.4       9.6   1.4e+04      81     109 ..     442     468 ..     431     506 .. 0.44
   2 !   51.9   0.1   5.9e-17   8.8e-14      21     170 ..     579     744 ..     552     745 .. 0.83
   3 !   44.8   0.0     9e-15   1.3e-11      14     147 ..    1444    1568 ..    1421    1597 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 9.6
                 ....GEEEESSS-B--.......-SEEEE CS
      ResIII  81 aykeigkkvsgdkkkakekdstnkkilvt 109
                 ++k+++kk++++++k+  ++++++k+ ++
  EFC37605.1 442 KFKDAQKKLKKEGRKI--GRKNQTKFNLS 468
                 3333444444444444..23333333332 PP

  == domain 2  score: 51.9 bits;  conditional E-value: 5.9e-17
                 .....TTSEEEEEESTTSTHHHHHHHHHHHH-S.............-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--.......-SEEE CS
      ResIII  21 s...krdkrglikmaTGtGKTlvaaklierllkkgkee........kflflvprkslleqtleefkkflseaykeigkkvsgdkkkakekdstnkkilv 108
                     k  +++l+ ++TG+GKT +a+ ++ r   ++ +         k++ ++p k+l   + e+f+k l +    + k+++gd +   +++ ++++++v
  EFC37605.1 579 YsayKTSENMLVCAPTGCGKTNIAMMTVLREIGQHFKGgkirreefKIIYIAPMKALAAEMVENFSKRLAPLG-ITVKEMTGDMQLT-KREVQQTQMIV 675
                 04557788999************966655555543333689999**********************9998864.5999999999999.99********* PP

                 EEHHHHHHTH........HHHTTT-SEEEEETGGGTTS......T.....TTHHHHHT---SEEEEEESS-S CS
      ResIII 109 ttiqsldadseeeeeeseellrdrfdviiiDEaHrlgak.....k.....swreilekfkeavllglTATpe 170
                 tt ++ d      +++s+++l +   +iiiDE+H l+++     +     + r++    +   l+gl+AT++
  EFC37605.1 676 TTPEKWDVTT---RKASDQALIQLTRLIIIDEVHLLNEDrgpviEsivarTLRQVETTQSMIRLVGLSATLP 744
                 **********...99***********************866555156666999998888899********86 PP

  == domain 3  score: 44.8 bits;  conditional E-value: 9e-15
                  HHT......TTSEEEEEESTTSTHHHHHHHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--.......-SEEEEE CS
      ResIII   14 nlleklkskrdkrglikmaTGtGKTlvaaklierllkkgkeekflflvprkslleqtleefkkflseaykeigkkvsgdkkkakekdstnkkilvtt 110 
                   +      + d+++li ++TG+GKTl a   i rl++ ++++k++ ++p k+l+   l e++k + ++  +++ +++gd      k  ++++i++tt
  EFC37605.1 1444 MTY-----HTDENILIGAPTGSGKTLAAELCIFRLFNTKPNQKVIYIAPLKALVRERLVEWEKKFVQKLGKKMVELTGDFTPD-VKLLKEADIVITT 1534
                  332.....7899******************************************99999998888888767777788888887.88889******** PP

                  HHHHHHTH........HHHTTT-SEEEEETGGGTTS. CS
      ResIII  111 iqsldadseeeeeeseellrdrfdviiiDEaHrlgak 147 
                   ++ d +s   ++++++       +i++DE H lg+ 
  EFC37605.1 1535 PEKWDGIS---RNWQNRSYVRDVGLIVMDEIHLLGSG 1568
                  ********...899999999999*********99885 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       5.6   8.4e+03      14      56 ..     621     667 ..     612     674 .. 0.69
   2 !   18.6   0.1   1.2e-06    0.0019      10     109 ..     801     950 ..     793     952 .. 0.58
   3 ?   -1.9   0.0       2.8   4.2e+03      95     110 ..    1171    1186 ..    1156    1186 .. 0.79
   4 !   28.9   0.0   7.6e-10   1.1e-06      35     110 ..    1696    1800 ..    1649    1801 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 5.6
                 TTTSEEEEEESSHH.HHHHHHHHHHHT...TSTEEEESTTSTHHHHH CS
  Helicase_C  14 eeggkilifvntid.rlekvklllekk...gikvavlhgelpqnere 56 
                 +e+ ki+ +++ +   +e+v+ + ++    gi+v  ++g+++  +re
  EFC37605.1 621 REEFKIIYIAPMKAlAAEMVENFSKRLaplGITVKEMTGDMQLTKRE 667
                 55667777777777533335555333367899999999999888876 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 1.2e-06
                 HHHTTTTSEEEEEESSHHHH...........................HHHHHH..............HHHT.....TSTEEEESTTSTHHHHHHHHHHH CS
  Helicase_C  10 lkleeeggkilifvntidrl...........................ekvkll..............lekk.....gikvavlhgelpqnereeileqf 62 
                 lk+ ++++++++fv+++++                            e                   +  +          ++h+ l  ++r+ + + f
  EFC37605.1 801 LKNLKREKQVMVFVHSRKETsttakalidlaveenaldmltagvkmsE----HtrkwvtkslekchnR--ElkelvPKGLGIHHAGLVRSDRNLVEKLF 893
                 455577777888888877441222222222232222222222222220....0222222222222220..12223344555567777777777888888 PP

                 HTTSSSEEEESGGGTSSSTSTTESEEE....ESSSSSSH......HHHHHHHTTSSS CS
  Helicase_C  63 nkgesdvLiatdvaerGidipkvnlVi....nfdlprnv......tsyiqriGRtgR 109
                  +g ++vL +t+ ++ G+++p+  ++i     +++ +++       +++q  GR+gR
  EFC37605.1 894 SEGIIRVLCCTSTLAWGVNLPSYCCIIkgteVYNAEKSTmtelgmLDIMQIFGRAGR 950
                 888899*********************6666566665546666769**********9 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2.8
                  SSHHHHHHHHTTSSST CS
  Helicase_C   95 rnvtsyiqriGRtgRa 110 
                   + + +iq++GR++Ra
  EFC37605.1 1171 SDCAFIIQSVGRIIRA 1186
                  556778********97 PP

  == domain 4  score: 28.9 bits;  conditional E-value: 7.6e-10
                  H..................HHHT.TSTEEEESTTSTHHHHHHHHHHHHTTSSSEEEESGGGTSSSTSTTESEEEESSSSSSH..........HHHHH CS
  Helicase_C   35 l..................lekk.gikvavlhgelpqnereeileqfnkgesdvLiatdvaerGidipkvnlVinfdlprnv..........tsyiq 102 
                  l                  l+++ ++ + ++h+ l+ ++++ + e f +g+++vL+at+ ++ G+++p   ++i     +++           ++ q
  EFC37605.1 1696 LrmdqnevisalelardthLKQFlQYGIGIHHAGLTPSDKKLVEELFHSGKIQVLVATSTLAWGVNLPAYFVIIKGTEFFEPstkryedyplVDVLQ 1792
                  1333333334444444444555589999****************************************77777743333333344456666799*** PP

                  HHTTSSST CS
  Helicase_C  103 riGRtgRa 110 
                  ++GR gR 
  EFC37605.1 1793 MAGRSGRP 1800
                  *******6 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.1   1.8e-05     0.026       6     113 ..     586     722 ..     581     743 .. 0.59
   2 !   10.1   0.0   0.00049      0.73       5     123 ..    1449    1589 ..    1445    1601 .. 0.71
   3 ?   -2.4   0.1       3.5   5.2e+03      48      88 ..    2116    2168 ..    2102    2197 .. 0.53

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.8e-05
      AAA_22   6 gilvvtGesGtGKTtllrrlleqldeeakaee...............erpevvfvtlpsstsskdllrellralglelka................... 70 
                   ++v++++G+GKT  + + + +  + ++ +                +               k l+ e+++++  +l                     
  EFC37605.1 586 ENMLVCAPTGCGKTNIAMMTVLRE-IGQHFKGgkirreefkiiyiapM---------------KALAAEMVENFSKRLAPlgitvkemtgdmqltkrev 668
                 5689**********8887766664.45555556785423333333221...............234444444444444444445666677777777656 PP

      AAA_22  71 ........erlsseellealeqalraravielliiDEaqhlr..seealeeL..r 113
                          + + +   ++  +++  + + +l+iiDE++ l+  +  ++e +  r
  EFC37605.1 669 qqtqmivtTPEKWDVTTRKASDQALIQLT-RLIIIDEVHLLNedRGPVIESIvaR 722
                 66666663333333333666666666666.***********87656666666433 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00049
      AAA_22    5 agilvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdllrellralglelka.......................erlsseel 78  
                  +  +++ +++G+GKT+ ++    +l    + ++++ +v+++ + +   ++ l ++  ++++  +k+                        + + + +
  EFC37605.1 1449 DENILIGAPTGSGKTLAAELCIFRL----FNTKPNQKVIYIAPLKALVRERLVEWEKKFVQKLGKKmveltgdftpdvkllkeadivitTPEKWDGI 1541
                  56788999********999766665....23335777776666666666666666666666655667778888999999998889988666666666 PP

      AAA_22   79 lealeqalraravielliiDEaqhlr..seealeeLrsllnl..srkgv 123 
                   +  ++ +  r+v +l++ DE++ l   + ++le + s++      +++
  EFC37605.1 1542 SRNWQNRSYVRDV-GLIVMDEIHLLGsgRGAILEVITSRMRYisWNTQT 1589
                  6888888888888.***********755488888885555444434444 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 3.5
      AAA_22   48 psst..sskdllrellralglelka..........erlsseellealeqalra 88  
                  p ++  ss++  +++ ++l ++ +           + + +++l +++ ++lr+
  EFC37605.1 2116 PRENteSSSEDIHNFIQNLAQKENVtglkqlldvkYQQGESALQKLISKYLRK 2168
                  44443433333333333333332223444555554444444455555555555 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.5   2.1e-06    0.0031       9     125 ..     584     719 ..     577     738 .. 0.69
   2 !    5.9   0.0      0.01        15       7      51 ..    1446    1488 ..    1438    1583 .. 0.69

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 2.1e-06
      AAA_19   9 kekvllvtaGpGtGKT.....rvlkhivallvelggvkp....eeillvaftgrAakelrerlaalgae.atTiHrlal.ldfddlltealelle.... 92 
                 +++++lv a+ G+GKT     +vl++i ++++  +         +i+ +a+ +  a e+ e+ ++ +a+   T+ +++  +++++++ ++ +++     
  EFC37605.1 584 TSENMLVCAPTGCGKTniammTVLREIGQHFKGGK---IrreeFKIIYIAPMKALAAEMVENFSKRLAPlGITVKEMTGdMQLTKREVQQTQMIVttpe 679
                 6789************3333233444555554433...1444599****************99887777756777653235555555555555556788 PP

      AAA_19  93 .......eaeeekklqeeellivDEfqdvdelqyrLlkal 125
                        +a+++  +q + l+i+DE+  ++e    +++ +
  EFC37605.1 680 kwdvttrKASDQALIQLTRLIIIDEVHLLNEDRGPVIESI 719
                 8888885545555555555*******98887666666555 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.01
      AAA_19    7 alkekvllvtaGpGtGKTrvlkhivallvelggvkpeeillvaft 51  
                  +++++++l+ a+ G+GKT   +  +  l +++  + ++++ +a+ 
  EFC37605.1 1446 YHTDENILIGAPTGSGKTLAAELCIFRLFNTK--PNQKVIYIAPL 1488
                  6788999***********99999999888888..44778777774 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.4   2.9e-05     0.043       1     120 [.     588     752 ..     588     761 .. 0.69
   2 !    6.6   0.0    0.0064       9.5       2      74 ..    1453    1569 ..    1452    1605 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.9e-05
                 EEEESSTTSSHHHHHH.HHHHHHTHE......................EEEEETTTCSSS...................................STTH CS
         AAA   1 vllyGppGtGKTllak.avakelgve......................fleisgsellsk...................................yvge 41 
                 +l++ p G+GKT +a   v +e+g++                                                                     ++  
  EFC37605.1 588 MLVCAPTGCGKTNIAMmTVLREIGQHfkggkirreefkiiyiapmkalA----------AemvenfskrlaplgitvkemtgdmqltkrevqqtqMIVT 676
                 7999********9997257888865533444444444443333333220..........1455556667777777777777778888899999999999 PP

                 HHHHHHHHHHHHHHTS..TS.EEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEESS.GGGSTHHHH CS
         AAA  42 sekkirelfkeakeka..kp.silfiDEidalaksrsgseseeeervvnqLlteldgvkkkeskvivigatnr.pdkldpall 120
                 +++k   + ++a+ +a  +    ++iDE++ l+++r      + e++v+  l++++  ++    + ++g + + p+ +d a  
  EFC37605.1 677 TPEKWDVTTRKASDQAliQLtRLIIIDEVHLLNEDR----GPVIESIVARTLRQVETTQS---MIRLVGLSATlPNYMDVANF 752
                 999999999999999999555***********9999....55666666666666666666...68888877765666666665 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0064
                  EEESSTTSSHHHHHHHHHHHH.....THEEEEEETTTCS.SS...................................STTHHHHHHHHHHHHHHHTS CS
         AAA    2 llyGppGtGKTllakavakel.....gvefleisgsell.sk...................................yvgesekkirelfkeakeka 57  
                  l+  p G GKTl+a+  +  l     +++++ i   + l  +                                   +v  +++k  ++ ++ ++ +
  EFC37605.1 1453 LIGAPTGSGKTLAAELCIFRLfntkpNQKVIYIAPLKALvRErlvewekkfvqklgkkmveltgdftpdvkllkeadIVITTPEKWDGISRNWQNRS 1549
                  555688**********999976655534444444433332224444455555555555666788888888888899988899999999998888888 PP

                  ...TSEEEEEETGGGHHHHH CS
         AAA   58 ...kpsilfiDEidalaksr 74  
                     +   +++DEi+ l++ r
  EFC37605.1 1550 yvrDVGLIVMDEIHLLGSGR 1569
                  88555999999999998877 PP

>> PhoH  PhoH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.0    0.0044       6.6      12      45 ..     578     611 ..     568     675 .. 0.81
   2 !   10.9   0.0   0.00015      0.22       3      67 ..    1432    1498 ..    1430    1520 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0044
                 HHHHHHH-SEEEEE--TTSSTTHHHHHHHHHHHH CS
        PhoH  12 ylealkkndivfaiGpaGtGKtylavalavealk 45 
                 +++a k+++ + + +p+G+GKt +a+++ ++ + 
  EFC37605.1 578 FYSAYKTSENMLVCAPTGCGKTNIAMMTVLREIG 611
                 45667777888999************98877654 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00015
                  ---SHHHHHHHHHHH.H-SEEEEE--TTSSTTHHHHHHHHHHHHTTS-SEEEEEE-S--T.T----S CS
        PhoH    3 kpktkeQkeylealk.kndivfaiGpaGtGKtylavalavealkkkkvkriiltrpavea.geelGf 67  
                  k  +  Q++++++   + + + + +p+G+GKt+ a  + +++++ k  +++i++ p      e+l  
  EFC37605.1 1432 KYFNPVQTQIFHMTYhTDENILIGAPTGSGKTLAAELCIFRLFNTKPNQKVIYIAPLKALvRERLVE 1498
                  55667788888887744445556679***************************99976444666655 PP

>> Helicase_PWI  N-terminal helicase PWI domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.1   2.7e-05      0.04      29      77 ..     366     414 ..     349     437 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.7e-05
  Helicase_PWI  29 aqelaeevleiLkseadelrelEnkLvelldydkfdliklllknrekiv 77 
                   +  +++ vl+iL+++ ++  +l+++L ++l+ + f+l +++++++ +i+
    EFC37605.1 366 TPGIENIVLDILQKKGQDAVQLQSRLFDALGENAFELMSIIMEHKSEIL 414
                   45678889*******9999***************************997 PP

>> Rpn9_C  Rpn9 C-terminal helix
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   1.5   0.00016      0.24      11      28 ..    1493    1511 ..    1492    1512 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00016
                  HHHHHHHHHH.HHHHHHHH CS
      Rpn9_C   11 KdrLVeWdeq.VtkLGkki 28  
                  ++rLVeW    V+kLGkk+
  EFC37605.1 1493 RERLVEWEKKfVQKLGKKM 1511
                  78*****9877*******9 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.0    0.0036       5.4      45      65 ..     583     603 ..     557     615 .. 0.84
   2 ?   -3.9   0.1       6.5   9.7e+03     106     121 ..     694     709 ..     684     712 .. 0.70
   3 ?    1.8   0.0      0.11   1.7e+02      46      65 ..    1448    1467 ..    1437    1511 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0036
   IstB_IS21  45 ekkenivllGpsGvGKshlai 65 
                 +++en++++ p+G GK+ +a+
  EFC37605.1 583 KTSENMLVCAPTGCGKTNIAM 603
                 678***************997 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 6.5
   IstB_IS21 106 llkvdllilDdlgllp 121
                 ++ ++l+i+D++ ll+
  EFC37605.1 694 IQLTRLIIIDEVHLLN 709
                 444589*****98876 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.11
   IstB_IS21   46 kkenivllGpsGvGKshlai 65  
                  + eni++  p+G GK+  a 
  EFC37605.1 1448 TDENILIGAPTGSGKTLAAE 1467
                  679*************7663 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   1.4       1.4     2e+03      92     178 ..     419     487 ..     388     526 .. 0.48
   2 ?    9.2   0.0   0.00063      0.94       1      76 [.     569     645 ..     569     674 .. 0.80
   3 ?    0.6   0.0      0.26   3.8e+02       3      41 ..    1435    1473 ..    1433    1510 .. 0.71
   4 ?   -2.8   0.0         3   4.5e+03     175     202 ..    1505    1534 ..    1484    1537 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.4
      AAA_11  92 Rvgneeeriseavksvsleekvekrlekeekaqlakeiskeleklakelrafeeeeekeklkkskekskskleqerrklkkerkels 178
                 R+ +++ ++ e ++s+s  +++ ++ +   + +l+ke +k                  +k +++++ s  + e+e+++lk+  ++++
  EFC37605.1 419 RMQMAD-NAVEGINSFSHVKMTTSKFKDA-QKKLKKEGRKIG----------------RKNQTKFNLSGGNSENELNELKSLYQTFK 487
                 444444.3444444444444444444332.111111111111................11222222222222222222222222222 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00063
      AAA_11   1 klndsqreaiksalseseitliqGPPGtgKT.ktivellsqllsrrkseeeksakpriLvCapSNaAvDellerllr 76 
                 +ln+ q + ++sa+++se  l+  P G+gKT  + + +l+++ ++ k  + ++++ +i + ap  a   e++e  ++
  EFC37605.1 569 HLNRVQSDVFYSAYKTSENMLVCAPTGCGKTnIAMMTVLREIGQHFKGGKIRREEFKIIYIAPMKALAAEMVENFSK 645
                 589****************************6344455555544445788899999999999988888888777665 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.26
      AAA_11    3 ndsqreaiksalseseitliqGPPGtgKTktivellsql 41  
                  n  q + ++ ++ ++e  li  P G+gKT +    + +l
  EFC37605.1 1435 NPVQTQIFHMTYHTDENILIGAPTGSGKTLAAELCIFRL 1473
                  777889999999999999***********5544444444 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 3
      AAA_11  175 kelskeleeaeesle..eevldeaeivltT 202 
                  ++l k++ e +   +   ++l+ea+iv+tT
  EFC37605.1 1505 QKLGKKMVELTGDFTpdVKLLKEADIVITT 1534
                  44444444444444455789*********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       888  (0.0495287); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.87u 0.25s 00:00:01.12 Elapsed: 00:00:00.45
# Mc/sec: 15450.51
//
Query:       EFC37606.1  [L=786]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-06   27.5  38.9       0.13   12.4   0.0    9.1  9  LRR_6     Leucine Rich repeat
    0.00068   20.0  42.1       0.96   10.0   3.8    7.4  6  LRR_4     Leucine Rich repeats (2 copies)
     0.0038   17.6  33.0        2.2    9.2   0.3    9.4  8  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
        3.8    7.4  40.4       0.12   12.2   1.9    7.5  6  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2      0.57   2.5e+03       7      19 ..     137     150 ..     136     150 .. 0.88
   2 ?   -1.0   0.0      0.57   2.6e+03       7      16 ..     435     444 ..     434     446 .. 0.84
   3 ?   -0.3   0.3      0.34   1.5e+03       3      17 ..     458     472 ..     456     473 .. 0.86
   4 !    9.5   0.1   0.00025       1.1       4      23 ..     487     507 ..     486     508 .. 0.89
   5 !   10.0   0.6   0.00016      0.73       4      18 ..     519     533 ..     517     536 .. 0.88
   6 ?    3.0   0.7      0.03   1.4e+02       2      16 ..     559     573 ..     558     575 .. 0.93
   7 !    4.9   1.7    0.0073        33       1      12 [.     586     597 ..     586     601 .. 0.89
   8 !   12.4   0.0   2.8e-05      0.13       1      15 [.     641     655 ..     641     663 .. 0.87
   9 !    8.8   0.2   0.00042       1.9       3      16 ..     685     698 ..     683     699 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.57
       LRR_6   7 eLdLsgNd.IgDeG 19 
                 eL Ls+ + ++DeG
  EFC37606.1 137 ELGLSSLEdLDDEG 150
                 79999999999999 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.57
       LRR_6   7 eLdLsgNdIg 16 
                 eL+ s+N+++
  EFC37606.1 435 ELNFSFNEMS 444
                 7******976 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.34
       LRR_6   3 thLteLdLsgNdIgD 17 
                 +++t L L+ N++ +
  EFC37606.1 458 RNITRLILTENNVEN 472
                 689*********976 PP

  == domain 4  score: 9.5 bits;  conditional E-value: 0.00025
       LRR_6   4 hLteLdLsgNd.IgDeGaeaL 23 
                 ++++LdLs N+ +g  G+ aL
  EFC37606.1 487 SIKHLDLSNNNfVGTIGVNAL 507
                 689***********9999887 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00016
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +L++L++s+N++g+ 
  EFC37606.1 519 SLEHLNISHNKLGGT 533
                 79***********86 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.03
       LRR_6   2 nthLteLdLsgNdIg 16 
                 n++L+eL +s +d++
  EFC37606.1 559 NCNLKELLISNCDLT 573
                 9************97 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.0073
       LRR_6   1 snthLteLdLsg 12 
                 +n++Lt+Ld+s 
  EFC37606.1 586 NNSSLTTLDISN 597
                 79********96 PP

  == domain 8  score: 12.4 bits;  conditional E-value: 2.8e-05
       LRR_6   1 snthLteLdLsgNdI 15 
                 snt+L++LdLsgN +
  EFC37606.1 641 SNTSLRYLDLSGNRF 655
                 69***********87 PP

  == domain 9  score: 8.8 bits;  conditional E-value: 0.00042
       LRR_6   3 thLteLdLsgNdIg 16 
                  hL +LdLs+N ++
  EFC37606.1 685 FHLNTLDLSSNTLT 698
                 59*********986 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.2   5.2e+03       2      30 ..     401     424 ..     400     429 .. 0.51
   2 !   10.0   3.8   0.00021      0.96       2      39 ..     459     502 ..     458     513 .. 0.80
   3 !    7.6   0.5    0.0012       5.4       2      20 ..     519     537 ..     518     551 .. 0.83
   4 !    7.1   4.2    0.0017       7.6       1      33 [.     560     598 ..     560     609 .. 0.79
   5 !    5.5   5.9    0.0056        25      11      33 ..     629     653 ..     589     667 .. 0.75
   6 !    6.6   0.6    0.0025        11       3      25 ..     687     708 ..     686     719 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.2
                 S--EEE--SS---E-S-HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdL 30 
                 +L++L++++  ++ +    ++++ +e+ L
  EFC37606.1 401 KLKKLSFRS--IS-LYHS-SCKSIREI-L 424
                 666666665..44.2222.26666666.5 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00021
                 S--EEE--SS---E-S-HH......H.-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplle......k.lpnLkeLdLsgNnlitdl 39 
                 n + L L  N++   ++l         +++ k+LdLs+Nn+++++
  EFC37606.1 459 NITRLILTENNVE-NDFLIhlssqkDfFKSIKHLDLSNNNFVGTI 502
                 7788999988988.55744445778679*************9988 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0012
                 S--EEE--SS---E-S-HH CS
       LRR_4   2 nLevLdLsnNqltdiplle 20 
                 +Le+L++s+N+l   +ll+
  EFC37606.1 519 SLEHLNISHNKLGGTDLLN 537
                 7999999999998777766 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0017
                 SS--EEE--SS---.E-S-...HH..H-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqlt.dipl...le..klpnLkeLdLsgN 33 
                 +nL++L +sn+ lt +      l+  ++ +L++Ld+s+ 
  EFC37606.1 560 CNLKELLISNCDLTqTMVEsllLAvaNNSSLTTLDISNT 598
                 69********99996655576533778*********554 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.0056
                 S---E-S-..HH...H-TT--EEE-.-S CS
       LRR_4  11 Nqltdipl..le...klpnLkeLdLsgN 33 
                 N ++      ++   ++++L++LdLsgN
  EFC37606.1 629 NEIS---DslFNsllSNTSLRYLDLSGN 653
                 3455...223333336888999999999 PP

  == domain 6  score: 6.6 bits;  conditional E-value: 0.0025
                 --EEE--SS---E-S-.HHH-TT- CS
       LRR_4   3 LevLdLsnNqltdipl.leklpnL 25 
                 L +LdLs+N lt+ ++ l+ l++L
  EFC37606.1 687 LNTLDLSSNTLTE-QFcLQ-LTQL 708
                 889*********5.45244.5555 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1         4   1.8e+04       6      16 ..     469     479 ..     459     481 .. 0.57
   2 !    7.4   0.1    0.0019       8.4       2      13 ..     488     500 ..     487     513 .. 0.77
   3 !    9.2   0.3   0.00048       2.2       1      13 [.     519     533 ..     519     549 .. 0.84
   4 !    6.3   0.3    0.0043        19       1      19 [.     561     579 ..     561     582 .. 0.84
   5 ?    1.4   1.8      0.18   7.9e+02       1      15 [.     589     603 ..     589     641 .. 0.77
   6 !    6.8   0.0     0.003        13       1      12 [.     644     655 ..     644     670 .. 0.86
   7 ?    2.6   0.2     0.069   3.1e+02       2      13 ..     687     701 ..     686     713 .. 0.75
   8 ?   -2.0   0.1       2.3     1e+04       5      12 ..     736     743 ..     732     753 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 4
       LRR_1   6 dLsnnpllglp 16 
                 +++n +l++l+
  EFC37606.1 469 NVENDFLIHLS 479
                 45666677766 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0019
       LRR_1   2 LrhLdLsnnpl.l 13 
                  +hLdLsnn++ +
  EFC37606.1 488 IKHLDLSNNNFvG 500
                 69*******9843 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00048
       LRR_1   1 nLrhLdLsnnpl..l 13 
                 +L+hL++s+n l  +
  EFC37606.1 519 SLEHLNISHNKLggT 533
                 69*********9554 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0043
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL++L +sn+ l++   +s
  EFC37606.1 561 NLKELLISNCDLTQTMVES 579
                 8***********9876655 PP

  == domain 5  score: 1.4 bits;  conditional E-value: 0.18
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++Ld+sn + l+l
  EFC37606.1 589 SLTTLDISNTHSLRL 603
                 589999998886443 PP

  == domain 6  score: 6.8 bits;  conditional E-value: 0.003
       LRR_1   1 nLrhLdLsnnpl 12 
                 +Lr+LdLs+n++
  EFC37606.1 644 SLRYLDLSGNRF 655
                 69********97 PP

  == domain 7  score: 2.6 bits;  conditional E-value: 0.069
       LRR_1   2 LrhLdLsnnpl...l 13 
                 L +LdLs+n l   +
  EFC37606.1 687 LNTLDLSSNTLteqF 701
                 889******986553 PP

  == domain 8  score: -2.0 bits;  conditional E-value: 2.3
       LRR_1   5 LdLsnnpl 12 
                 L L+nn++
  EFC37606.1 736 LQLENNFF 743
                 55788886 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.2   5.2e+03      11      24 ..     267     280 ..     266     282 .. 0.69
   2 ?    0.3  10.5      0.14   6.1e+02       2      61 .]     459     530 ..     458     530 .. 0.59
   3 ?    0.8   1.7     0.092   4.1e+02      22      35 ..     585     598 ..     560     611 .. 0.61
   4 ?   12.2   1.9   2.6e-05      0.12       3      39 ..     618     657 ..     616     661 .. 0.81
   5 ?    5.4   0.1    0.0035        16      26      39 ..     686     699 ..     683     712 .. 0.84
   6 ?   -1.8   0.1      0.63   2.8e+03      47      59 ..     729     741 ..     726     744 .. 0.55

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.2
                 S--SEE-TTSSTT- CS
       LRR_8  11 NrltslddeaFkgl 24 
                 +++t+++  +F+++
  EFC37606.1 267 SNFTHVHEISFRDM 280
                 56777777777776 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.14
                 T-SEEE-TTS--SE...E-TTSSTT.-TT--EEE--SS---G.GGGGGG.TT--......S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrlts...lddeaFkg.lsnLkvLdLsnNlltt.lspgaf.sgLp......sLrsLdLsgNrL 61 
                 n t+L+L+ N+ ++   ++ ++ k+ +++ k+LdLsnN+    +  +a+   L+      sL++L++s+N+L
  EFC37606.1 459 NITRLILTENNVENdflIHLSSQKDfFKSIKHLDLSNNNFVGtIGVNALfTALNnyssgiSLEHLNISHNKL 530
                 666777777777664545666666667899999999997644355444313333222222688888888876 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.092
                 TT-TT--EEE--SS CS
       LRR_8  22 kglsnLkvLdLsnN 35 
                  ++s+L++Ld+sn 
  EFC37606.1 585 ANNSSLTTLDISNT 598
                 45667777777665 PP

  == domain 4  score: 12.2 bits;  conditional E-value: 2.6e-05
                 -SEEE-TTS--SEE-TTSSTT.-..TT--EEE--SS---G CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg.l..snLkvLdLsnNlltt 39 
                 L+++++s  +l++++d+ F++ l  ++L++LdLs N+ + 
  EFC37606.1 618 LKKMSISTCSLNEISDSLFNSlLsnTSLRYLDLSGNRFKE 657
                 8999999999999999999994333579999999998775 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.0035
                 T--EEE--SS---G CS
       LRR_8  26 nLkvLdLsnNlltt 39 
                 +L++LdLs+N+lt 
  EFC37606.1 686 HLNTLDLSSNTLTE 699
                 68999999999875 PP

  == domain 6  score: -1.8 bits;  conditional E-value: 0.63
                 T--S-.EEE--SS CS
       LRR_8  47 gLpsLrsLdLsgN 59 
                 gLp ++ L L++N
  EFC37606.1 729 GLPLIDILQLENN 741
                 4555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (786 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       847  (0.0472419); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.56
# Mc/sec: 4244.18
//
Query:       EFC37607.1  [L=500]
Description: hypothetical protein NAEGRDRAFT_59723 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0032   16.1 151.5     0.0071   14.9 148.8    2.5  2  TPH       Trichohyalin-plectin-homology domain
  ------ inclusion threshold ------
       0.14   11.7   0.0       0.33   10.5   0.0    1.6  1  Tom6      Mitochondrial import receptor subunit Tom6, fungal
       0.15    9.9   0.1       0.23    9.3   0.1    1.1  1  VacA      Vacuolating cyotoxin


Domain annotation for each model (and alignments):
>> TPH  Trichohyalin-plectin-homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9 148.8   1.2e-06    0.0071      12     304 ..     182     474 ..     172     480 .. 0.92
   2 !    8.1  23.4   0.00014      0.83      24     110 ..     411     497 ..     408     499 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.2e-06
         TPH  12 nskllaakvnkerdaQieekkrikaeekeeerrldemmekerekaleeeeekeeerkekrkeyrqeLeeQieereqkrqeeeeekle.Ekeqldeivek 109
                 ++k ++a+   + ++Q ee+ r+++ + ++e+++ e+ ++  ++++eee+++eeer+ +  e +++ ++Q+e+ + ++q+  ++k+e E e++++  ++
  EFC37607.1 182 RQKQKQAELRETLQKQKEENHRQEEIKIKKEQKYIEEQKARAQREAEEEKKREEERRLRILEEKRVRDQQLEQSKIRKQMIDQKKKEeEEELVNKLKKQ 280
                 68999****************************9999999999999*********************************99998888466666666666 PP

         TPH 110 ieeedeaeaeekkekqkelreeldefneeqkerkekekeeekeederileylkekeereeereaerkekeeekereiarlraqqekaedekaerdelra 208
                 i++e e+e + ++ ++kel   + ++ne  k+rke+e+++e eed++  +  +ek++++e r++ + +k  e++  +  l++++e + deka+ de++a
  EFC37607.1 281 INKEKEKEVQTRESNKKEL-SSFLAYNETIKQRKEEEAKKEIEEDLKSFKLFEEKQRQQELRREMEMKKMYERQSLSIALSNKLEANLDEKAKEDEIKA 378
                 6666666666666666666.566789************************************************************************* PP

         TPH 209 klaqeeaerkwrqkereeaekkarqreelkeareeqvelkerrlaeeaereeeefervlrkqaedeekeqeeaekrrekrlehrrelekqieeree 304
                 ++++ e e k + + ++++ + ++q+ee++ + + q++ k   ++e   +e++ +e++ ++ +++e++e   +++ +e  ++ r+ l +q++e+++
  EFC37607.1 379 DRIHSEMEMKKENEDKKKRDRLQKQKEEMMDTLARQIQGKFDNRKEVLMEEQRRKEQIEEDLRKAEQEELDRKRRFKEGLKNQRESLSEQVKEKQH 474
                 **********************************************99999999****************************************87 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00014
         TPH  24 rdaQieekkrikaeekeeerrldemmekerekaleeeeekeeerkekrkeyrqeLeeQieereqkrqeeeeekleEkeqldeiveki 110
                  ++Qi+ k  +++e   ee+r  e++e++ +ka++ee +++++ ke  k++r++L eQ++e+++  +++    + E ++   +++ki
  EFC37607.1 411 LARQIQGKFDNRKEVLMEEQRRKEQIEEDLRKAEQEELDRKRRFKEGLKNQRESLSEQVKEKQHVTMKQSGMSDIEMKLNADRLKKI 497
                 689************************************************************988888777777766666666665 PP

>> Tom6  Mitochondrial import receptor subunit Tom6, fungal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   5.6e-05      0.33       9      30 ..     124     145 ..     116     146 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 5.6e-05
        Tom6   9 eqfketPaftvllnvaLFvaGV 30 
                 ++  e Pa+++++ ++LF+ G+
  EFC37607.1 124 QETEEEPAYAIGTLGGLFGGGI 145
                 566789**************97 PP

>> VacA  Vacuolating cyotoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.1   3.8e-05      0.23      20      68 ..     133     180 ..     129     186 .. 0.90

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 3.8e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        VacA  20 avgtvsgllswglkqaeeankapdkpdkvwriqagkgfdefpnkeydly 68 
                 a+gt+ gl++ g+k++ + nk p   d +w   a k  +e+ n +++ y
  EFC37607.1 133 AIGTLGGLFGGGIKKTAKPNKPPS-GDDIWAAIAVKDTEEYHNEQHQEY 180
                 89*******************886.688*************99998766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (500 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5082  (0.283451); expected 358.6 (0.02)
Passed bias filter:                      746  (0.0416086); expected 358.6 (0.02)
Passed Vit filter:                       376  (0.0209716); expected 17.9 (0.001)
Passed Fwd filter:                       103  (0.00574488); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 2.38u 0.43s 00:00:02.81 Elapsed: 00:00:00.71
# Mc/sec: 2111.54
//
Query:       EFC37608.1  [L=159]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    6.2e-08   32.5   0.2      0.026   14.4   0.1    3.1  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0   0.00037       6.7       5      29 ..      10      34 ..       6      37 .. 0.86
   2 !    8.4   0.0   0.00011         2      58      92 ..      43      77 ..      39      82 .. 0.90
   3 !   14.4   0.1   1.5e-06     0.026       5      69 ..      84     147 ..      80     152 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00037
                HHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr  5 vlkellaGglagavatlvttPldvv 29
                 + e l+G+lag+ + ++ +P d++
  EFC37608.1 10 NQLEYLSGSLAGLSTLSFQYPYDYI 34
                566899*****************98 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00011
                HHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr 58 eeGlrglyrGllpnllrvapasalkfvlyetlkrl 92
                + G+r+ + Gl+     ++ +++l+f+l++  k++
  EFC37608.1 43 KPGFRACFNGLSDVAPISILYRGLYFGLFDIWKEM 77
                679***************************99997 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 1.5e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGll 69 
                 ++k+++++    +++++ + P+ ++  r     ++ +k+ ++++++ l ki  e+G++gl++G++
  EFC37608.1  84 LTKKVVVAQGVSIISGVSVRPFRLATDRALG-YDRIQKKFYKGTFRELWKIRNEQGVKGLFKGVM 147
                 5666666666777777778887777666444.44445556777999999999***********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       369  (0.0205812); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.30s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 1008.58
//
Query:       EFC37609.1  [L=385]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.9e-87  292.4   6.0    6.6e-87  292.2   6.0    1.0  1  Serpin    Serpin (serine protease inhibitor)


Domain annotation for each model (and alignments):
>> Serpin  Serpin (serine protease inhibitor)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  292.2   6.0   3.7e-91   6.6e-87       2     370 ..      12     384 ..      11     385 .] 0.94

  Alignments for each domain:
  == domain 1  score: 292.2 bits;  conditional E-value: 3.7e-91
                 HHHHHHHHHHHHHHHHSTTSSEEE-HHHHHHHHHHHHHTB-HHHHHHHHHHHTGCC..HCHHHHHHHHHHHHHHHCSSGGTSEEEEEEEEEEEETTSEB CS
      Serpin   2 antkfaldlfkalskekpskNiifSPlsistaLallllGakgetaeellevLglne..sdeeelhealekllsrlneseekdkelkianglfvekglkl 98 
                 + +kf+ +l++ + ++k+++N++fSP+si++a+ ++  Ga+ge+ +el + Lg+++  s+ ee ++ +e++ +++ + + +++ l++an  fve++ +l
  EFC37609.1  12 SHNKFSSQLYQTITQKKQKENVVFSPVSIYLAMLMATSGANGESLTELVNGLGIDKapSTIEEWRQIVEPFATTFYS-NLNTSILNVANNAFVEQNATL 109
                 679***************************************************88777777777888888888888.99******************* PP

                 -HHHHHHHHHHHS-EEEEE-TTTHHH.HHHHHHHHHHHHTTTSSSSSSSTTSS-TTECEEEEEEEEEEEEBSS--BGGGEEEEEEESSSSEEEEEEEEE CS
      Serpin  99 keeflklakklykaevesvdfkddee.arkkINswvekqTngkIkdllsegsidsdtrlvlvNaiyFkGkWeepFqpeatreekFyvnegekvkvpmMs 196
                 + ++++ +kk ++a+v++ df++++e  +kkIN+wv+++Tn++Ikdl+++g ++s trlvlvNai+F G+W+++F++e+  + +Fy+ ege+ +  mMs
  EFC37609.1 110 DGKYKDHVKKAFQAQVTQCDFAGNAEgETKKINEWVSSKTNQMIKDLIEPGLLTSLTRLVLVNAIHFLGAWKKAFDKENSYNGTFYGAEGEN-TCRMMS 207
                 ******************************************************************************************99.9****7 PP

                 EEEEEEEEEETTTTEEEEEEEBGG.SEEEEEEEESSTTTHHHHHHHHSHHHHHHHHHHGEEEEEEE..EEEEE-EEEEEEEEHHHHHHH..TTHCGGGS CS
      Serpin 197 qegkfkyaedeelnakvlelpYkg.nlsmlillPdeekgleelekkltaerleewlsklkmkkeke..evslPkfkieesidlkevLqk..lGlkdlFs 290
                 +++  + ++ +e ++  + lp+++ +++m+i+  + ++++++  +   a++l++ ++   +++e +  ++++P f++e+ ++l e+Lq+  +++k+ F+
  EFC37609.1 208 KSDSKE-QYGSEGGYHWVTLPFSDvKYKMTIVAVK-DQSFQQTLDGWVAQKLNQGIDTAFPTNEAKlsSFRFPAFELEQGLELSEILQSapFNIKKPFT 304
                 777666.444567*********999********95.456*****99999**9999999988888888999******************844699***** PP

                 TTTB.BTTTBSSSSEEEEEEEEEEEEEESSSEEEEEEEEEE.CCTTCS-SSCEEEEECSEEEEEEEETTTTEEEEEEEESS CS
      Serpin 291 eneadlsgiskkeplfvsevlhkafievnEeGteaaaatav.atllskksspvefkvdrPFlflireektgliLFlGkvvn 370
                  nead+s++++ke++f+++v+hka i+v+E+G ea+aata+ + +ls  ++++ f++  PF f++ +++++++LF+Gkv++
  EFC37609.1 305 -NEADFSNLLTKEDIFIDKVIHKAAIKVDEAGAEASAATAIvMRTLSYDPNQISFIAESPFTFVLSDDSSKTVLFVGKVNK 384
                 .***************************************8899**********************************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       736  (0.0410508); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2361.57
//
Query:       EFC37610.1  [L=748]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-68  232.2   6.8    1.1e-68  232.2   6.8    2.8  2  Peptidase_M8  Leishmanolysin
    1.5e-10   41.2  43.3    0.00023   21.5   6.8    4.3  3  EGF_2         EGF-like domain


Domain annotation for each model (and alignments):
>> Peptidase_M8  Leishmanolysin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  232.2   6.8   1.2e-72   1.1e-68       1     518 [.      24     571 ..      24     584 .. 0.80
   2 ?   -4.4   6.9      0.65   5.8e+03     414     439 ..     699     724 ..     612     732 .. 0.79

  Alignments for each domain:
  == domain 1  score: 232.2 bits;  conditional E-value: 1.2e-72
  Peptidase_M8   1 hrCiyDkllarvlqsvkqqhrpPgsvsalelPyvsadaissaltvdkaladstspsvassadwgtlriavsaedltdpd....yyCsavGqli.... 89 
                   h+Ci+++l+a      k + +p g  s++e        +++++  ++  ++st+++    + w+ +r+   ++ l        + C avG++     
    EFC37610.1  24 HKCIHNELMAA----EKTNTHPRGIFSTMES----SFKLQAQHNLKRSILQSTATTA--TETWSNIRVLFRTDYLGPDSdtesRSCKAVGDYYwtga 110
                   99*******43....2333333455555554....4567899999999999998765..568******99998885332466799999999862222 PP

  Peptidase_M8  90 ............knhaGaldiCkaeDiLteekRnilvktllpralqlhaerLkvrqvq.gki.kvtgmdgdvCse...fkvPekhvtvGv..sdaDl 167
                               +  +    +Ck+ D++ +     +v+++lp+  + +   L+v+ v+ g++ k+ +  +  C++     vP++ +++G+   +aD 
    EFC37610.1 111 ntptstktqcltDSSSNCWRVCKDTDVIDSSFLSEIVSSMLPTIKEDYSRMLQVPTVKdGDYpKIFNA-NSRCGSqggVAVPSDIIANGLdgKNADA 206
                   211111111111222334568**********************99************98555266555.556666566678********94448*** PP

  Peptidase_M8 168 vlyvasvPseegvlawavtCqlfs.dgrpvvgvinipaasissaydqlvvrvvahelahaLGfsktlfeelelieevknlrkrdy............ 251
                   +++v+s+P+e+gvl wa+ C l+s  +rp+v+++ni ++  + +  + ++ vv he  haLGfs+++  ++    + k l+   +            
    EFC37610.1 207 IFFVTSRPTETGVLGWAIPCILDSiTKRPLVAQLNISPKLGNYT--KEKLSVVRHEALHALGFSNSFLSSFYDRANKKTLDASAVysvvnksfvdst 301
                   **********************984789**********976655..778899************98877665555555555544445555555**** PP

  Peptidase_M8 252 ......kvpvlnsptvvakaReqygCptLeyleleDqGgagtagshlkkRnakdelmagavsag.lysaLtlavfeDlGfYkadfskaevlvWgnna 341
                         +v+ l++p++  +aR++y+CptL+++ +e+ Gg+g+a sh++k ++k+elm ++vs   + s+ t+a feD G Y+ +fs+a  l+Wg+ +
    EFC37610.1 302 gttqsvSVTKLKTPKILEVARKYYNCPTLDGVPMEEYGGSGSAVSHWEKSIMKNELMVASVSGElVLSSFTIAYFEDSGWYRGNFSHAQRLTWGKDM 398
                   ***98778889**********************************************9988887699****************************** PP

  Peptidase_M8 342 gCdflskkClednitewpelfCnste.ralr.........CstdRlslGkCsitrqedplPtyyqYf.tdlslgGsdafmdyCPviegysngaCnqd 427
                   gC++++ +C e+  t+    fC+s   +            C+ d  s+  C+ +++ + l  yy++f + ++ gG+d+fmdyCP+   +++g C   
    EFC37610.1 399 GCAMANYRC-ENWPTKNVGYFCSSESpS-KSyfqttstssCTHDLKSKSYCNSAKYYNDLG-YYEHFpSSPKQGGTDSFMDYCPFQIAFTDGNC--- 489
                   *********.7777777799**987742.22456999999************999999886.5555526788**********************... PP

  Peptidase_M8 428 sssadpslkefevfsdasRCldgalrpkqstgiteeynglCanvkCdrakrtlsvqvygssgyvaCteGesvelatvsaafveggyivCpa 518
                     s+ p   ++e f+ +s C+++++    + +  ++   +C +  C++ ++++ v+ +       C++ ++ +    s+     gy+ Cp 
    EFC37610.1 490 -VSGYPIKTSGEEFGSSSACFEASISLTSN-SDIKTADSRCLKYSCGNETLNIYVGSK----KFSCPKDQTAQTKYDST---FFGYVKCPL 571
                   .889999999************99877666.45566677********99887777666....56899999988777773...349999996 PP

  == domain 2  score: -4.4 bits;  conditional E-value: 0.65
  Peptidase_M8 414 PviegysngaCnqdsssadpslkefe 439
                      +gy n  Cn+d+ +ad s+ + +
    EFC37610.1 699 GQCVGYNNCKCNTDTINADCSISKVN 724
                   35789**************9998765 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   6.8   2.5e-08   0.00023       6      32 .]     615     640 ..     611     640 .. 0.89
   2 !   18.6  13.3     2e-07    0.0018       4      32 .]     652     679 ..     645     679 .. 0.88
   3 !   11.9   7.3   2.5e-05      0.22       4      32 .]     690     718 ..     687     718 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 2.5e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ +G+C++ + +C+C++g +G++C
  EFC37610.1 615 LVCNRRGKCISNN-NCQCFTGAFGDQC 640
                 57*******9666.8************ PP

  == domain 2  score: 18.6 bits;  conditional E-value: 2e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+g+GtC+ +  +C C +g++G++C
  EFC37610.1 652 NSSVCSGQGTCDGLD-NCNCYAGHYGDYC 679
                 3799********777.8************ PP

  == domain 3  score: 11.9 bits;  conditional E-value: 2.5e-05
       EGF_2   4 s.deiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                 s ++ C+ +G+Cv  + ++C+C++    ++C
  EFC37610.1 690 ShSSVCSSNGQCV--GyNNCKCNTDTINADC 718
                 44789********..5348***998777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (748 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 4484.05
//
Query:       EFC37611.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.06   13.1   0.1       0.21   11.4   0.0    2.0  2  L27       L27 domain


Domain annotation for each model (and alignments):
>> L27  L27 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   1.2e-05      0.21      26      41 ..      38      53 ..      37      54 .. 0.93
   2 ?   -2.9   0.0      0.33   5.8e+03       3      18 ..      83      98 ..      82     100 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 1.2e-05
         L27 26 kvLqsphlqaLlevHD 41
                 +L sph+ +L e++D
  EFC37611.1 38 SILASPHFEYLIELYD 53
                59*************9 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.33
         L27  3 ralelLedLqslsdvn 18
                +a+++++ L ++ + +
  EFC37611.1 83 LANDVVNNLLGTIEKS 98
                6788988888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1585.38
//
Query:       EFC37612.1  [L=979]
Description: hypothetical protein NAEGRDRAFT_59725 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.7e-05   22.3   7.5        1.8    8.8   0.2    6.1  5  LRR_6          Leucine Rich repeat
    0.00022   21.4  14.0    0.00022   21.4  14.0    1.8  2  YL1            YL1 nuclear protein
  ------ inclusion threshold ------
      0.046   13.4   0.0       0.15   11.8   0.0    1.8  1  Redoxin        Redoxin
       0.41    9.4  23.2       0.37    9.6   9.1    2.3  2  Apt1           Golgi-body localisation protein domain
       0.84    9.7  14.2        1.9    8.5  14.2    1.5  1  Asp-B-Hydro_N  Aspartyl beta-hydroxylase N-terminal region


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.2     0.034   1.2e+02       3      24 .]     762     784 ..     760     784 .. 0.86
   2 !    8.8   0.2   0.00049       1.8       2      24 .]     786     809 ..     785     809 .. 0.91
   3 ?    1.5   0.0      0.11     4e+02       2      23 ..     815     837 ..     815     838 .. 0.87
   4 !    7.3   0.1    0.0015       5.4       3      24 .]     921     942 ..     919     942 .. 0.92
   5 ?   -1.9   0.0       1.4     5e+03       3      11 ..     945     953 ..     943     959 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.034
       LRR_6   3 thLteLdLsgNd.IgDeGaeaLa 24 
                 t++++++L++N  + D+ ++ La
  EFC37612.1 762 TSVKHVNLTSNInLKDDDLKYLA 784
                 899********889999988886 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00049
       LRR_6   2 nthLteLdLsgNd.IgDeGaeaLa 24 
                 +  L +L+L++N+ ++++G++ La
  EFC37612.1 786 CEQLVSLSLAHNKtLNGSGLKYLA 809
                 66799****************997 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.11
       LRR_6   2 nthLteLdLsgNd.IgDeGaeaL 23 
                 + +L+ L++ ++  + D+ +e +
  EFC37612.1 815 CETLQFLNVDWCSkFEDQALEHI 837
                 569*********99999988887 PP

  == domain 4  score: 7.3 bits;  conditional E-value: 0.0015
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 +++++L +++  I+++G++ La
  EFC37612.1 921 HNIRHLTVNFAPITNDGVKLLA 942
                 799****************998 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 1.4
       LRR_6   3 thLteLdLs 11 
                 ++L++Ld++
  EFC37612.1 945 HYLEYLDVM 953
                 78*****97 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   1.6       1.8   6.6e+03     107     115 ..      58      78 ..      33     113 .. 0.35
   2 !   21.4  14.0   6.1e-08   0.00022      18     105 ..     228     313 ..     203     345 .. 0.62

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.8
                 xxxxxxxx............x RF
         YL1 107 kkkkkidp............q 115
                 kk +++ +            +
  EFC37612.1  58 KKTRQFRRdrdtqistpptsS 78 
                 111111111111111111110 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 6.1e-08
                 xxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1  18 eeeedelellFaE....eedDeefeseeeeeeeensDsdfdsdeedeesdeeedeeegekelerqerkkrkkekkkrkaqkkkskkkkkkqk 105
                 e   d l++  +E     edDee+ s+e++ee+ +s++  ++de+   sd+e  +e++e   +r+ ++    ++kk+ka+k+++k+++++ +
  EFC37612.1 228 EY-YDHLNEYLKEtvnsNEDDEEYHSNEDDEED-VSEISTEEDEG---SDTETSDEDEEYPKKRKSKAST-PSSKKSKADKSTAKASSSTTN 313
                 33.566666666688889********9998887.47755544444...5555555444553234444444.555666655555555444333 PP

>> Redoxin  Redoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   4.1e-05      0.15      39      83 ..     143     187 ..     139     209 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.1e-05
                 TT-HHHHHTHHHHHTHHHHHHCSTTTEEEEEESSSHHHHHHHHHT CS
     Redoxin  39 afcPtCsaehpyleklaellkekgvdvvavvadndafvkefwgke 83 
                 + cP C+++    e+ + l ++ gv+  ++ a+ndaf k++   +
  EFC37612.1 143 TKCPICTRNKQSCEEAKSLMGKLGVSNPFLKAQNDAFNKKVTRHK 187
                 38***********************************66554443 PP

>> Apt1  Golgi-body localisation protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   6.1     0.002       7.1     327     408 ..      46     185 ..      21     197 .. 0.42
   2 ?    9.6   9.1    0.0001      0.37     283     375 ..     225     321 ..     223     366 .. 0.51

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.002
        Apt1 327 sssss.ssssssassssssssrssslelrlkpt.......sstssssssessssssskkrsseesslessaservkssr.................... 397
                 ++s + ++s++++++++ +++r          t       ss+sss+++ +++++s++ +++++ss +++++      +                    
  EFC37612.1  46 DNSTNsTNSTRTKKTRQFRRDRD---------TqistpptSSSSSSLNNINNNNNSRNLEKNNSSSSNNNNN------Nmvsvapgisiipgnqhlinn 129
                 11111111222222222222221.........1222222133222222222222222222222122222222......022222333444444445555 PP

        Apt1 398 .............................................asddleemksR 408
                                                              ++d ++++++R
  EFC37612.1 130 nanslperieggatkcpictrnkqsceeakslmgklgvsnpflkaQNDAFNKKVTR 185
                 55566666666666666666666666666666666666666666666666666666 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0001
        Apt1 283 LeeevgkklfeYiFPkrdsdaqeasmvkess.seeddesdeesessssss.......ssssssassssssssrssslelrlkptsstssssssesssss 373
                 L++e ++ l eY+  +++s++ ++    e + +e+d+e+ +e+++++++        ++++  ++++s+ s+ ss++++ +k+t+++sss+++  ssss
  EFC37612.1 225 LKREYYDHLNEYLKETVNSNEDDE----EYHsNEDDEEDVSEISTEEDEGsdtetsdEDEEYPKKRKSKASTPSSKKSKADKSTAKASSSTTNVASSSS 319
                 788999999999998888888887....22223333333333333333322222111111111111111111111111111122333333333333333 PP

        Apt1 374 ss 375
                 ++
  EFC37612.1 320 FA 321
                 33 PP

>> Asp-B-Hydro_N  Aspartyl beta-hydroxylase N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  14.2   0.00053       1.9      80     205 ..     178     306 ..     154     340 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00053
  Asp-B-Hydro_N  80 eeaevvaeeeeqlaeekekqkveeevkEqlkkvkeeivvkeeeeegieeepqleeekkllkedsderqeeleagkvkeevEeslkv...eetvsee 172
                      ++ v+++++++  ++ ++ ++ee k  l k++ +i  +eee  +  +++  ++ ++ lke+++++ +++e +  +++ E++ ++   e+  s+ 
     EFC37612.1 178 AFNKKVTRHKGKIKMKEFNASIREEFKQLLGKIEGKIFRNEEEYSTFLKREYYDHLNEYLKETVNSNEDDEEYHSNEDDEEDVSEIsteEDEGSDT 273
                    556778899999999999***********************999999***************9999999999888888877665541113344444 PP

  Asp-B-Hydro_N 173 akkdmkekaseeenekskepveeaekekaeake 205
                    ++ d  e+  +++++k + p  ++ k  +++ +
     EFC37612.1 274 ETSDEDEEYPKKRKSKASTPSSKKSKADKSTAK 306
                    444445555555555555555443333333322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (979 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2096  (0.116906); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.99u 0.34s 00:00:01.33 Elapsed: 00:00:00.55
# Mc/sec: 5406.75
//
Query:       EFC37613.1  [L=808]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (808 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1144  (0.0638072); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.29s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 4729.09
//
Query:       EFC37614.1  [L=299]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   9.1e-100  334.7   3.1      1e-99  334.6   3.1    1.0  1  Phospholip_B  Phospholipase B
  ------ inclusion threshold ------
      0.034   14.3   0.1      0.058   13.5   0.1    1.3  1  Toxin_20      Huwentoxin-II family


Domain annotation for each model (and alignments):
>> Phospholip_B  Phospholipase B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  334.6   3.1  1.1e-103     1e-99     238     530 ..       1     294 [.       1     295 [. 0.95

  Alignments for each domain:
  == domain 1  score: 334.6 bits;  conditional E-value: 1.1e-103
  Phospholip_B 238 iyKkYklreedravvpgtnvsfSsyPgllaSlDDfyitssrLvviettnevfnktLykkikpersvllwvRvmianrlaesgreWveiFsrensgTy 334
                   ++K+Y+l++  + ++++++v+fSsyPg l S DD+y t+ +Lvviett+++ n+tLy++++p+ s+l w Rv++anr+a+sgreW e+Fs +n gTy
    EFC37614.1   1 MMKTYTLNF-ANPLTKSRTVTFSSYPGSLGSNDDYYQTDGGLVVIETTIGILNNTLYDNTHPQ-SLLSWFRVVLANRMATSGREWFEVFSINNGGTY 95 
                   79******5.556677***********************************************.********************************* PP

  Phospholip_B 335 nnqwlvldykkfke.skelpsglfwvveQlPgkveaeDvTevlnsegYwasyniPyfkeiynlsgyaaqvekyGdsy...syettprakiferdqsn 427
                   nn+w++ld+kkf + + +l+++lfwv+eQ+Pg+v  +D+T+ l ++gY+asyn+P++++iy+  gya++v+k+ ++y   sy++++r++if+rdq+ 
    EFC37614.1  96 NNEWMILDVKKFIPgQAQLTKDLFWVIEQIPGTVVGSDQTNLLSTRGYFASYNVPFYPSIYEKTGYAEYVKKFPETYhymSYDKCARSEIFRRDQHL 192
                   **************788999*******************************************************99555689************** PP

  Phospholip_B 428 vtdleslkrlmrynnYkkdplskgkpenaiaaRgDLn...asggtaafGaiDlKvtsielveklqaravsGPttdtqppFdWskskllevvrhqGlp 521
                   v+dl s++r+m+y nY +d++s g+p   i+aR DL    ++g+++  G++D+K+ si++ + + +r  sGP ++ +p+F++++ +  ++++h+Glp
    EFC37614.1 193 VKDLPSMQRIMQYDNY-HDEFSFGNPDWVISARDDLApnvPNGQKSCGGGYDCKISSISKWNFVFFR--SGPAHQFTPVFKFEN-QCGPQYSHVGLP 285
                   ****************.********************77777888899**********999988886..9*************9.888889****** PP

  Phospholip_B 522 dvwnFefvt 530
                     wnF++++
    EFC37614.1 286 LEWNFPWIQ 294
                   *******97 PP

>> Toxin_20  Huwentoxin-II family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   6.4e-06     0.058      16      34 ..     229     247 ..     225     251 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 6.4e-06
    Toxin_20  16 PCKPkGkKKCsGGWkCKlk 34 
                 P  P G+K C GG+ CK+ 
  EFC37614.1 229 PNVPNGQKSCGGGYDCKIS 247
                 6679*************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       327  (0.0182386); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1826.30
//
Query:       EFC37615.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.8e-19   68.3   0.0      9e-19   67.6   0.0    1.3  1  Ras        Ras family
    1.1e-18   67.5   0.0    2.2e-18   66.6   0.0    1.5  1  Roc        Ras of Complex, Roc, domain of DAPkinase
    2.1e-06   27.3   0.1    3.3e-06   26.7   0.1    1.2  1  Arf        ADP-ribosylation factor family
    0.00013   22.0   0.0    0.00024   21.2   0.0    1.4  1  MMR_HSR1   50S ribosome-binding GTPase
     0.0018   17.7   0.1     0.0027   17.1   0.1    1.3  1  Gtr1_RagA  Gtr1/RagA G protein conserved region


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.6   0.0   2.5e-22     9e-19       1     142 [.     189     336 ..     189     350 .. 0.87

  Alignments for each domain:
  == domain 1  score: 67.6 bits;  conditional E-value: 2.5e-22
                 EEEEEESTTSSHHHHHHHHHHSS....CSSSCTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdk....FkeeyesTigvdfytkeievd.gkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwv 94 
                 K++l Gd + GKtsll+  ++++     ++++++Tig+df +k++++   ++vkl++wD  G e+f++++  +yr+a++ill+ d +s++ ++++++ v
  EFC37615.1 189 KVLLDGDYSSGKTSLLNCAMNETpvdpSNNHHITTIGMDFAIKNFHFGdTTKVKLQLWDQCGPERFRQITLPFYRHASVILLLVDPSSTHVLRSMNEKV 287
                 78899************9999763322578999***********99864789*********************************************** PP

                 HHHHHHSTTTSEEEEEEETTTGGG.G-SS-HHHHHHHHHHHT.SEEEEEB CS
         Ras  95 eeikrvaeenvpivLvGnKvDlee.kravsteegeelakelg.lkfletS 142
                 e ik+ a++  +++L+ +K D ++  r +s+e++ +la ++  + +l+++
  EFC37615.1 288 EVIKNNATK-PEVILITTKKDKKDeVRLISNEQADKLAYDNFgTLHLDIT 336
                 *****9995.9**********9985799*********9654336666665 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.6   0.0   6.2e-22   2.2e-18       1     120 []     189     308 ..     189     308 .. 0.85

  Alignments for each domain:
  == domain 1  score: 66.6 bits;  conditional E-value: 6.2e-22
                 EEEEESSTTSSHHHHHHCHCT-CC....C-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHH... CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkf....sekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrss... 92 
                 Kv+l Gd ++GKtsll+  ++++     ++++ +tig+df+ k+++ + g     +++kvkl++WD +G erfr+++  ++r+a++++l++d +s    
  EFC37615.1 189 KVLLDGDYSSGKTSLLNCAMNETPvdpsNNHHITTIGMDFAIKNFH-F-G-----DTTKVKLQLWDQCGPERFRQITLPFYRHASVILLLVDPSSThvl 280
                 89999***************98753333678899******999874.2.2.....235799*******************************4443134 PP

                 HCHHHHHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  93 enlkeWlkelkkvagkspvilvgnkiDl 120
                 ++++e ++ +k++a+k  vil+ +k D+
  EFC37615.1 281 RSMNEKVEVIKNNATKPEVILITTKKDK 308
                 78999********************995 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.1   9.1e-10   3.3e-06      16     134 ..     189     318 ..     183     346 .. 0.74

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 9.1e-10
                 EEEEEESTTSSHHHHHHHHHHSSCEE.....CSSSSS..EEEEEEEE...TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHH CS
         Arf  16 rilllGLDnaGKtTilkklkleelvt.....tvPTig..fnveelei...knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeL 104
                 ++ll G  ++GKt +l+  ++e  v+     ++ Tig  f +++ ++    ++k+++wD  G e+ R++   ++++  +++ +vD + ++ l++++e++
  EFC37615.1 189 KVLLDGDYSSGKTSLLNCAMNETPVDpsnnhHITTIGmdFAIKNFHFgdtTKVKLQLWDQCGPERFRQITLPFYRHASVILLLVDPSSTHVLRSMNEKV 287
                 6777777789******9888876654445557888774467788876655889****************************************999999 PP

                 HHHCTSGCCTTSEEEEE.EE-TTSTTSS-HH CS
         Arf 105 kalleeeelkevallvl.aNKqDlpealsee 134
                 + + ++ +  ev+l+     K+D    +s+e
  EFC37615.1 288 EVIKNNATKPEVILITTkKDKKDEVRLISNE 318
                 8877766666655543312344444444443 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   6.7e-08   0.00024       2     113 ..     190     304 ..     189     305 .. 0.72

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 6.7e-08
                 EEEEESTTSSHHHHHHHHHTS..TEEESSSTTSSSSEEEEEEE.....ETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.TTCSHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltge..kaivsdkpgtTrdinegrvk.....lkgkeielvDtpGliegaseekglgkaflaleeadlillvvdas.eeklkp 92 
                 v++ G   +GK++L+n  ++e  +   ++++ tT+ + ++  +     + + +++l+D  G  e   + ++++  f +   a++ill+vd s ++ l+ 
  EFC37615.1 190 VLLDGDYSSGKTSLLNCAMNEtpVDPSNNHHITTIGMDFAIKNfhfgdTTKVKLQLWDQCG-PE---RFRQITLPFYR--HASVILLLVDPSsTHVLRS 282
                 66778999************9755577888899988877754466665556889*******.88...33366666665..578*******775446677 PP

                 HHHHHHHHHHHTTSE.EEEEEE CS
    MMR_HSR1  93 ldeeleelleeakkp.lilvln 113
                 ++e++e ++++a+kp +il+ +
  EFC37615.1 283 MNEKVEVIKNNATKPeVILITT 304
                 7777777777777883455555 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.1   7.6e-07    0.0027       1     123 [.     189     308 ..     189     341 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 7.6e-07
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnyl.....ardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleed 94 
                 kvLL G  +sGKts+ +   +++       ++++++g+   +++ ++  + +++l+lwD  G e+f + +l       +r+ +v++ ++D +s+++ ++
  EFC37615.1 189 KVLLDGDYSSGKTSLLNCAMNETPvdpsnNHHITTIGMDFAIKNFHFGDTTKVKLQLWDQCGPERFRQITL-----PFYRHASVILLLVDPSSTHVLRS 282
                 89************9888877664111115677788888889999999999*************9998874.....56788999999999997766555 PP

   Gtr1_RagA  95 letlkeilealrqyspeakvfvlihKmDl 123
                 +   +e +e ++++  + +v  +  K D+
  EFC37615.1 283 M---NEKVEVIKNNATKPEVILITTKKDK 308
                 5...5555556666666666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      437  (0.0243739); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2069.62
//
Query:       EFC37616.1  [L=576]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.9e-48  163.7   0.0    2.5e-47  161.3   0.0    1.9  2  Peptidase_C2  Calpain family cysteine protease
      8e-06   25.7   0.0    3.3e-05   23.7   0.0    2.0  2  VHL           VHL beta domain


Domain annotation for each model (and alignments):
>> Peptidase_C2  Calpain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0     0.074   6.6e+02     170     255 ..     134     221 ..     109     233 .. 0.64
   2 !  161.3   0.0   2.8e-51   2.5e-47      26     290 ..     294     569 ..     278     573 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.074
  Peptidase_C2 170 elkeapkelfkilkkalergslmgcsieassaeelea..klengLvkgHaYsvtaveevelkkekvkLirlrnPWGeveWkGawsdks 255
                   ++++a++e +k ++++++ + l+  si+ +++++++   + e+g  ++H Ys    +   +     ++  l+n  G+ve+  + sdks
    EFC37616.1 134 KMTKAREEDWKLIRSRFDGHELVDISIRNDTSRKYNVfrVDEEGNQTSHGYSAPISTFWATFAYPGNVFLLKNECGSVEFVLKVSDKS 221
                   2344555568888888888888888877555554443446788999999998655444444445555666666666666666666666 PP

  == domain 2  score: 161.3 bits;  conditional E-value: 2.8e-51
  Peptidase_C2  26 eWkRpkeivenpkfivdgasrtdikqGelgdCwllaaiasltlkekllkrvvpkeqsfeekyaGifhfrfwr..fgewvdvvvDDrlPtvngklvfv 120
                   +  R+++++++p+++  ++s +d  qG+l dC+l+++i+  +l+++ll++v+++ + ++    G++ + f+   ++e ++ ++DD+lP  ng+l f+
    EFC37616.1 294 DCVRAQNLFKRPAIFK-NISVMDPIQGKLEDCFLISSISGAALRTRLLRKVFTHCEAIDP-KLGLYALTFYLepNNEKMTLLLDDYLPAENGHLKFA 388
                   5579999999999755.9************************************988877.59****9999622688999***************** PP

  Peptidase_C2 121 ksaeknefWsalleKAyAklhgsyealkggst......sealedftggvtesiel........elkeapkelfkilkkalergslmgcsieassaee 203
                   +s+++ e+W +l+eK +Akl+g y++++ ++       s+ l+ + gg +++++         ++  ++ +++  ++k ++++  +  + +   +e 
    EFC37616.1 389 HSQDRGELWISLIEKGIAKLVGDYDKINPQTNshlfypSNILSLLLGGRSKQLDWfsgqsttaTDMMKKGTFWPLIEKLMDSSLSVPVCGTKPGKEG 485
                   ***************************9887612222246788999***999999999998873344455589999998887776666666677788 PP

  Peptidase_C2 204 leaklengLvkgHaYsvtaveevelkkekvkLirlrnPWGeveWkGawsdkskeWeevseeekeklklkkkedgefwmsfedflknF 290
                   +++  +ngLv+ H Ys+++ +++   ++++kL+ lrn WG+ e++G+wsd+s+eW++  ++ k+ l+ ++++dg f+m++e f + F
    EFC37616.1 486 SDSINSNGLVNAHGYSLLSYRKFP--EHDLKLVNLRNTWGRIEYNGPWSDNSPEWDQ-YPDVKKALEYRNADDGCFYMTYEAFENCF 569
                   89999*****************95..579**************************88.6788999999***************9998 PP

>> VHL  VHL beta domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0   3.6e-09   3.3e-05       8      64 ..      11      67 ..       4      80 .. 0.85
   2 ?   -2.1   0.0      0.43   3.9e+03       6      38 ..     152     184 ..     146     201 .. 0.78

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 3.6e-09
         VHL  8 ipvevvFcnrsprvvkplWidfeGePqsYeelkPgtgrrmttyvgHpWlFRDAetdd 64
                 ++ ++F+n+ +  ++ +Wid+eG+ q+++ l+ g +   ++  +Hp++ R  ++++
  EFC37616.1 11 HKCPIIFHNTLSEPIQMIWIDYEGNEQPFTVLNSGGKCCQQAGATHPFIMRRMNDEK 67
                57889*******************************9999***********655443 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.43
         VHL   6 sripvevvFcnrsprvvkplWidfeGePqsYee 38 
                  ++ v++  +n ++r  + + +d eG+ +s+  
  EFC37616.1 152 GHELVDISIRNDTSRKYNVFRVDEEGNQTSHGY 184
                 567788999999999999999999888776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       468  (0.026103); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 3316.84
//
Query:       EFC37617.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0079   16.0   1.7       0.11   12.4   0.3    3.3  3  F-box       F-box domain
  ------ inclusion threshold ------
       0.27   11.2   1.1        1.6    8.7   0.2    2.4  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.3   1.3e-05      0.11       2      39 ..       5      43 ..       4      46 .. 0.86
   2 ?   -3.3   0.0       1.1   9.6e+03      11      21 ..      80      90 ..      66      92 .. 0.86
   3 ?    0.6   0.0      0.06   5.4e+02      22      38 ..     149     165 ..     141     168 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.3e-05
                HHHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTT CS
       F-box  2 tlsrLPsevlrhILerLplsd.llalrrVSkgwrilids 39
                ++++L+ ++l++++   + s+ l+a++ V+  wr+++++
  EFC37617.1  5 KILQLSQDILCNVIIPYCNSHtLIAFAGVCSEWRRIVKE 43
                5889999999999997666667***************96 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.1
                HHHHHHTS-HH CS
       F-box 11 lrhILerLpls 21
                l++I+++++ +
  EFC37617.1 80 LLQIFSQMEIR 90
                78999999876 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.06
                 HHHHHCTT-HHHHHHHT CS
       F-box  22 dllalrrVSkgwrilid 38 
                 ++ +lr  ++++ +l+d
  EFC37617.1 149 EVENLRTICTNLLNLTD 165
                 6889**********987 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.2   0.00018       1.6       7      36 ..      12      42 ..       6      46 .. 0.78
   2 ?    0.0   0.0     0.091   8.2e+02       9      17 ..      80      88 ..      80      94 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00018
  F-box-like  7 EiLlqIFs.yLppsdLlrlalVCrrWrrval 36
                +iL+ +   y +  +L++ a VC+ Wrr++ 
  EFC37617.1 12 DILCNVIIpYCNSHTLIAFAGVCSEWRRIVK 42
                56666665355777999************84 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.091
  F-box-like  9 LlqIFsyLp 17
                LlqIFs+++
  EFC37617.1 80 LLQIFSQME 88
                8*****976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       425  (0.0237046); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 3214.81
//
Query:       EFC37618.1  [L=620]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.6e-30  104.7  14.4    5.6e-30  104.7  14.4    2.3  2  Paf1        Paf1
  ------ inclusion threshold ------
        1.8    7.3  25.6      0.042   12.7  14.8    2.4  2  Apt1        Golgi-body localisation protein domain


Domain annotation for each model (and alignments):
>> Paf1  Paf1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.6  10.7       1.8   1.6e+04     374     420 ..      64     110 ..      22     123 .. 0.60
   2 !  104.7  14.4   6.3e-34   5.6e-30       2     415 ..     144     590 ..     143     601 .. 0.70

  Alignments for each domain:
  == domain 1  score: -5.6 bits;  conditional E-value: 1.8
        Paf1 374 eeeekseeeeekeeekeeaeeeseaeseeessdeeeeeakselkess 420
                 + +++s+ ++++++ ++ ++++++++s+++ss+++++++ s++k++s
  EFC37618.1  64 HRSSSSSRNSSNPSSSHPHDDKRKRPSSSKSSSSKHRSSGSSSKHDS 110
                 22223444555555555555555555555555555444444444443 PP

  == domain 2  score: 104.7 bits;  conditional E-value: 6.3e-34
        Paf1   2 liarirYsNnLPdppfdpKflkypfep.erfveyksssLerelkheiltdadlGmpldLinidgyldgdeesnepvkLdpkDrkLLedeeaskasskrs 99 
                 ++++++++  LP++ +dp +l+yp +  e+f+ yk +sLe+++k+e+lt+++lG++++Lin+  y + d    e++kLdp+D+ LL++ +++k++ +r 
  EFC37618.1 144 FLCNMKFQTGLPEILLDPVLLEYPKDFtENFIGYKTTSLEKNHKFELLTENNLGINMNLINPFVYYK-D----ESAKLDPEDELLLKPVKSAKKEIARE 237
                 89************************8799*************************************.6....3469************9888887777 PP

        Paf1 100 k..qhskkVswLRrTEYiste.fnrfgvsa....t.dkqetklgknlkk.keqeedlyrdresqikaiektFedakkplkdlkHpskknlkaVealpll 189
                    + s+  swL+   Y+    ++++ +      + d +e  ++ ++k+    ++ + + r +  k+ ++ F+  +++l+    p  +++ka+  + ll
  EFC37618.1 238 LveNLSSRPSWLKAPTYVDMInYKKAVKGYgedlIqDVEEEHVQ-KIKPkTVPRKVEEKSRFEKAKQLDAKFQ--SDTLT-RTLPNGQKVKAIACYSLL 332
                 633557889*********99866665543211113233333333.3333244444444555566667788887..44444.3789************** PP

        Paf1 190 PDfelwknpyaqvkfdgdpatdskekdlkeeeqkerlsqaiirpvmeeege.............efvayflpteetlekrkr................. 258
                 P+f+++  +++   f +d  t   ++++  e   +++s ++i    + +++             + ++y++p ++++e+ +                  
  EFC37618.1 333 PNFATMGTKFMAANFGSDNHTLLGKRGRFGELTAKDASDSLILI--QPTDDiilaekaaddrnvQVAQYYVPVSNNDEEELFnsektvgnivelvreyg 429
                 ******************99988888888888899999999874..444445788889999999999*****888777766669*************** PP

        Paf1 259 .....dleeeideeedeeyefklaReYnwkvenkaskgyeenlllvfrddkkkavyYneletrveLrkrRkkeeeeskkdklvvklrelnee...elka 349
                      + +++++ ++++e +fkl  +  ++ ++ ++ + e +++l f+d+   +  Y+ +++ v+ +   kk+ + +  +k++++ ++++ee   e+ +
  EFC37618.1 430 gtiyeKNSSNVQVNKENEKRFKLP-NHLMSKDKMTQAEIEPCVALRFDDN-TSQCVYSYIQEGVNFKVLPKKK-KRRVFTKVKLNGKNPDEEvqfESLT 525
                 *98886677777777788889876.6667777777789999********5.8999999999999887655552.3367777777777777662222222 PP

        Paf1 350 rekresefdpleee..keeeeeeeeeeeeekseeeeekeeekeeaeeeseaeseeessdeeeeeakse 415
                    +++e  +  ++  + e+ee +ee+ ++   ++ee+ee  + ++++s ++   +s+de+e+ ++s+
  EFC37618.1 526 DIIASTEELGATKQgpSYEDEEMQEETTQQ---QSEEEEEIISPSDRGSAKKRAVQSDDEDENMEESA 590
                 222333334444444322222222222222...33333333333333333333333333333333332 PP

>> Apt1  Golgi-body localisation protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7  14.8   4.7e-06     0.042     314     391 ..      33     119 ..       8     222 .. 0.54
   2 ?   -0.1   3.0     0.036   3.2e+02     316     384 ..     544     582 ..     471     618 .. 0.47

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.7e-06
        Apt1 314 seeddesdeesessssss.........ssssssassssssssrssslelrlkpt......sstssssssessssssskkrsseesslessase 391
                 s+++++ ++  +s    s         s++s+++s++sssssr+ss+ ++++p          sss+ss+s+++ss ++++++++s +s+ s+
  EFC37618.1  33 SSSSSHHRSGGSS----SgshhrsgssSRDSHRDSHRSSSSSRNSSNPSSSHPHddkrkrP--SSSKSSSSKHRSSGSSSKHDSRSQRSKPSS 119
                 1111111111111....12222333332333333333333333333333333323444331..222222222222222222222222222222 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.036
        Apt1 316 eddesdeesessssss.......ssssssassssssssrssslelrlkptsstssssssessssssskkrsseess 384
                 ed+e +ee+++++s++       s                                     ++ s +k++ +++++
  EFC37618.1 544 EDEEMQEETTQQQSEEeeeiispS-------------------------------------DRGSAKKRAVQSDDE 582
                 111111111111111111122211.....................................111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (620 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1765  (0.0984439); expected 358.6 (0.02)
Passed bias filter:                      532  (0.0296726); expected 358.6 (0.02)
Passed Vit filter:                       116  (0.00646996); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.88u 0.38s 00:00:01.26 Elapsed: 00:00:00.53
# Mc/sec: 3514.82
//
Query:       EFC37619.1  [L=510]
Description: chaperonin complex component, TCP-1 beta subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
   8.9e-149  496.2   2.8     1e-148  496.0   2.8    1.0  1  Cpn60_TCP1  TCP-1/cpn60 chaperonin family


Domain annotation for each model (and alignments):
>> Cpn60_TCP1  TCP-1/cpn60 chaperonin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  496.0   2.8  5.8e-153    1e-148       3     477 ..      42     509 ..      40     510 .] 0.97

  Alignments for each domain:
  == domain 1  score: 496.0 bits;  conditional E-value: 5.8e-153
                 HHHHCCSSTTXXEEEEEETTSEEEEEXSHHHHHHCSXXXSHHHHHHHHHHHHCCCCCTTCHHHHHHHHHHHHHHHHHHHHCTXXHHHHHHHHHHHHHHH CS
  Cpn60_TCP1   3 divkttlGPkGmdKmlvnkggkvvvTnDGatilkeleiehPaakllveaaesqdeevGDGTttvviLageLleeaekliaagvhpttiiegyekaleka 101
                 +++kt+lGP+GmdKm v++ g+v+vTnDGatil++++++h +akllve+++sqd+e+GDGTt vv+Lag+Lle++ +l+++g+hpt+i egyeka+e a
  EFC37619.1  42 NTLKTSLGPRGMDKMMVSPDGDVTVTNDGATILEKMQVNHQVAKLLVELSQSQDDEIGDGTTGVVVLAGALLEKSLELLDRGIHPTKISEGYEKACEFA 140
                 799************************************************************************************************ PP

                 HHHHHHHXEEBXSCSTT.HHHHHHHHHHCTTSSXXSTHHHHHHHHHHHH.HCHCCCSEECSCCCEECCCCEECECTTSEEESEEEESS--SSTTSSCEE CS
  Cpn60_TCP1 102 leaLkeiaveisseekdreeLlkvartslsskltskeaeelsklvvdAv.klieenekeldlgrikvvkieggsledselveGlvldkgvlspdmpkkl 199
                  ++L++i+ +++ ++++ e L k a+t+l+sk+++k +e+++k++vdAv  + + ++k+++l+ ikv+ ++gg+leds lv+G+v+dk++++p+m k++
  EFC37619.1 141 CDELEKISDRLEFSKDNIEPLFKTASTTLNSKIINKFREKFAKMCVDAVlDVADIDRKDVNLDLIKVEGKTGGRLEDSCLVDGIVVDKEMSHPQMVKSI 239
                 *************************************************77777777****************************************** PP

                 ECEEEEEESS-BS--HHCCHHHCCCCSCCHHHHHHHHHHHHHHHHHHHHHHTTECEEEESS-B-HHHHHHHHHCT-EEE-S--HHHHHHHHHHHT--EB CS
  Cpn60_TCP1 200 enakvllldvsLeiektetkttvvlsdaeeleklekaeekqleellekiiksgvnvvvcqkgiddlalhflakngilalrrvkkkdlerlakatGatav 298
                 enak+++l++++e++kt++k++v+++++e++++l + e++++ e++++ ++sg+n+++cq+g+dd+a+h+l +n++  +r+v   ++e +a+atG++++
  EFC37619.1 240 ENAKIAILTCPFEPPKTKNKGNVEIDTVEKYNSLYELEQNYFVEQVKRCKDSGANLIICQWGFDDEANHLLLQNELPSVRWVGGVEIELIAIATGGRII 338
                 *************************************************************************************************** PP

                 SCGGGGGCGC-EEEEEEEECCETT..CCEEEEECESSSSXEEEEEEESTCCCHHHHHHHHHHHHHHHHHHHHHHEEEETTTCHHHHHHHHHHCCCCTSX CS
  Cpn60_TCP1 299 ssledltpeelGtakkveeekigs..ekttiieevksgkiatillrgatdtvldeieraiedAlnvvknaiedekvvpGGGatelelakklkeyaksvs 395
                  ++e+l+ ++lG+a++v+e ++g+  +k+++ie++++ k++ti +rg ++++++e++r+i+dAl+vv+n+++d+++v+GGG++e++++ +l+++a++v+
  EFC37619.1 339 PRFEELSADKLGSAGRVREVTFGTtsDKMIFIENCANTKAVTIFVRGGNKMIIEEAKRSIHDALCVVRNLVRDNRIVYGGGSAEIACSLRLSNEADKVT 437
                 *********************997669************************************************************************ PP

                 CCHHHHHHHHHHHHTHHHHHHHHHCTSXHHHHHHHHHHHHHTTXTTEEEETTTTCEEECCCCTXEEEHHHHHHHHHHHHHHH CS
  Cpn60_TCP1 396 geeqlaieafakALevipktLaeNaGldpievlaklraahnkgekelgidvesgeiidlveagvvDplkvkrqalksAteaa 477
                 + +q+ai+ fa+ALe +p +La+N+G++pie +++++      e     ++ ++ ++d++++gv++ l  k+q + +A++++
  EFC37619.1 438 DVDQYAIRSFADALEFVPLALAQNSGYNPIEFVSNVKG-----E-----QCMNKGTKDMKDQGVFETLVGKQQQMRLASQVV 509
                 ************************************87.....3.....23455679*********************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (510 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       753  (0.041999); expected 358.6 (0.02)
Passed bias filter:                      599  (0.0334096); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.56
# Mc/sec: 2741.21
//
Query:       EFC37620.1  [L=1584]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.9e-55  182.2   8.5    7.6e-06   25.7   0.0   10.8 10  NHL           NHL repeat
    2.7e-45  152.4 258.5    3.4e-06   27.3   9.2   19.1 19  EGF_2         EGF-like domain
    2.4e-16   59.7   5.4        1.4    9.2   0.0    8.8  8  Arylesterase  Arylesterase
      9e-16   58.2   2.4    1.5e-05   24.7   0.0    5.7  4  SGL           SMP-30/Gluconolactonase/LRE-like region
    1.1e-13   51.2   0.2        3.9    7.7   0.0    8.3  8  Str_synth     Strictosidine synthase
     0.0033   17.7   2.2     0.0033   17.7   2.2   17.9 17  EGF           EGF-like domain
  ------ inclusion threshold ------
       0.18   11.9   0.2         17    5.6   0.0    2.6  2  DUF4485       Domain of unknown function (DUF4485)
       0.39   11.4   9.8        3.1    8.5   1.0    2.8  2  MBG_2         MBG domain (YGX type)
        3.1    7.7   5.0         38    4.1   0.1    4.6  4  NAGLU_N       Alpha-N-acetylglucosaminidase (NAGLU) N-termina
        4.5    7.2   6.0        1.2    9.0   2.1    2.0  2  DUF3487       Protein of unknown function (DUF3487)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       4.2   7.5e+03      13      25 ..     126     138 ..     122     139 .. 0.84
   2 !   25.7   0.0   4.2e-09   7.6e-06       1      27 [.     178     204 ..     178     205 .. 0.95
   3 !   23.1   0.0   2.9e-08   5.2e-05       1      27 [.     234     260 ..     234     261 .. 0.95
   4 !   19.7   0.0   3.4e-07   0.00061       1      27 [.     290     316 ..     290     317 .. 0.93
   5 !   19.3   0.0   4.4e-07   0.00079       1      27 [.     347     374 ..     347     375 .. 0.95
   6 ?   -1.9   0.0       2.4   4.3e+03      12      25 ..     520     533 ..     515     534 .. 0.79
   7 !   25.7   0.0   4.2e-09   7.6e-06       1      27 [.     573     599 ..     573     600 .. 0.95
   8 !   23.1   0.0   2.9e-08   5.2e-05       1      27 [.     629     655 ..     629     656 .. 0.95
   9 !   19.7   0.0   3.4e-07   0.00061       1      27 [.     685     711 ..     685     712 .. 0.93
  10 !   19.3   0.0   4.4e-07   0.00079       1      27 [.     742     769 ..     742     770 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 4.2
                 TEEEEEECCCTEE CS
         NHL  13 GdiyVaDsenhrv 25 
                 +++y +D  nhr+
  EFC37620.1 126 NELYMTDVLNHRI 138
                 678889999***9 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 4.2e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+G+++++nG+iy+aD+ nhr+++
  EFC37620.1 178 LNSPNGLSISQNGEIYIADTLNHRIRK 204
                 799**********************97 PP

  == domain 3  score: 23.1 bits;  conditional E-value: 2.9e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+Gv +++nG+iy+aD+ nhr+++
  EFC37620.1 234 LNSPNGVHISQNGEIYIADTLNHRIRK 260
                 799**********************97 PP

  == domain 4  score: 19.7 bits;  conditional E-value: 3.4e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P Gv v++nG+iy+aD+ nhr+++
  EFC37620.1 290 LNSPYGVHVSQNGEIYIADTLNHRIRK 316
                 68999********************97 PP

  == domain 5  score: 19.3 bits;  conditional E-value: 4.4e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P Gv v+ +n++i++aD+ n+r+++
  EFC37620.1 347 LNSPKGVFVSpNNNEILIADTSNNRIRK 374
                 799***********************97 PP

  == domain 6  score: -1.9 bits;  conditional E-value: 2.4
                 TTEEEEEECCCTEE CS
         NHL  12 nGdiyVaDsenhrv 25 
                  +++y +D  nhr+
  EFC37620.1 520 RNELYMTDVLNHRI 533
                 6889999999***9 PP

  == domain 7  score: 25.7 bits;  conditional E-value: 4.2e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+G+++++nG+iy+aD+ nhr+++
  EFC37620.1 573 LNSPNGLSISQNGEIYIADTLNHRIRK 599
                 799**********************97 PP

  == domain 8  score: 23.1 bits;  conditional E-value: 2.9e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+Gv +++nG+iy+aD+ nhr+++
  EFC37620.1 629 LNSPNGVHISQNGEIYIADTLNHRIRK 655
                 799**********************97 PP

  == domain 9  score: 19.7 bits;  conditional E-value: 3.4e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P Gv v++nG+iy+aD+ nhr+++
  EFC37620.1 685 LNSPYGVHVSQNGEIYIADTLNHRIRK 711
                 68999********************97 PP

  == domain 10  score: 19.3 bits;  conditional E-value: 4.4e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P Gv v+ +n++i++aD+ n+r+++
  EFC37620.1 742 LNSPKGVFVSpNNNEILIADTSNNRIRK 769
                 799***********************97 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   1.9     0.012        21       4      15 ..     404     416 ..     402     419 .. 0.80
   2 ?   -3.7   2.2       9.4   1.7e+04       6      15 ..     550     559 ..     547     563 .. 0.75
   3 ?    0.2   2.2      0.56     1e+03      20      32 .]     774     786 ..     771     786 .. 0.92
   4 !   15.5   7.7   9.7e-06     0.017       5      32 .]     799     825 ..     796     825 .. 0.91
   5 !   18.2   7.0   1.3e-06    0.0024       7      32 .]     840     864 ..     836     864 .. 0.93
   6 !   26.6   5.1   3.1e-09   5.6e-06       6      32 .]     878     903 ..     873     903 .. 0.92
   7 !   14.8   6.8   1.5e-05     0.027       7      32 .]     918     942 ..     913     942 .. 0.91
   8 !   22.2   7.4   7.5e-08   0.00013       7      32 .]     957     981 ..     953     981 .. 0.93
   9 !   19.5   5.3   5.2e-07   0.00093       7      32 .]    1006    1030 ..    1001    1030 .. 0.93
  10 !   24.7   7.9   1.2e-08   2.2e-05       5      32 .]    1043    1069 ..    1040    1069 .. 0.90
  11 !    9.0   8.1   0.00098       1.8       5      32 .]    1082    1108 ..    1074    1108 .. 0.87
  12 !   16.1  10.7   6.1e-06     0.011       5      32 .]    1136    1162 ..    1133    1162 .. 0.91
  13 !   17.0  11.3   3.2e-06    0.0058       5      32 .]    1175    1201 ..    1167    1201 .. 0.89
  14 !   17.8   6.1   1.7e-06    0.0031       5      32 .]    1214    1240 ..    1211    1240 .. 0.91
  15 !   27.3   9.2   1.9e-09   3.4e-06       1      32 []    1257    1287 ..    1257    1287 .. 0.92
  16 !    7.4   5.8    0.0032       5.7       7      32 .]    1302    1328 ..    1298    1328 .. 0.80
  17 !   17.2   4.4   2.8e-06    0.0051       7      32 .]    1347    1371 ..    1344    1371 .. 0.90
  18 !    6.3   8.5    0.0071        13       6      32 .]    1385    1410 ..    1380    1410 .. 0.88
  19 ?    0.2   2.1      0.57     1e+03       1      13 [.    1410    1424 ..    1410    1427 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.012
       EGF_2   4 s.deiCgghGtCv 15 
                 + ++ C+g+G+C+
  EFC37620.1 404 NsKSVCNGNGICN 416
                 34889*******9 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 9.4
       EGF_2   6 eiCgghGtCv 15 
                  +C+gh  C+
  EFC37620.1 550 QNCNGHSDCD 559
                 5699999998 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.56
       EGF_2  20 qCdCdsgyqGktC 32 
                  C C s + G +C
  EFC37620.1 774 ICNCTSEWGGQYC 786
                 5************ PP

  == domain 4  score: 15.5 bits;  conditional E-value: 9.7e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C ghG C++++  C+C+s y G  C
  EFC37620.1 799 ISACEGHGNCISPN-ICECNSTYGGEFC 825
                 578********999.***********99 PP

  == domain 5  score: 18.2 bits;  conditional E-value: 1.3e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C g+G C+++  +C C+++++G  C
  EFC37620.1 840 VCTGNGECIQPD-ECICNTNWTGQFC 864
                 6********888.9***********9 PP

  == domain 6  score: 26.6 bits;  conditional E-value: 3.1e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G+Cv+++  C+C+s+++G  C
  EFC37620.1 878 LVCNGNGQCVSPN-ICECNSSWSGELC 903
                 68********999.***********99 PP

  == domain 7  score: 14.8 bits;  conditional E-value: 1.5e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+G C+ +  +C+C+s + G +C
  EFC37620.1 918 VCSGNGACIGPD-VCECNSTWGGQYC 942
                 7********888.9************ PP

  == domain 8  score: 22.2 bits;  conditional E-value: 7.5e-08
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+G C +++ +C C+s+++G+ C
  EFC37620.1 957 VCNGNGECFQPN-ECICNSNWTGPFC 981
                 6*******9788.9************ PP

  == domain 9  score: 19.5 bits;  conditional E-value: 5.2e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G C+++  +C C+s++ G +C
  EFC37620.1 1006 VCSGNGLCIRPD-ECLCNSNWAGQYC 1030
                  6********999.9************ PP

  == domain 10  score: 24.7 bits;  conditional E-value: 1.2e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+g+G+Cv+++ +C Cds+++G  C
  EFC37620.1 1043 ETACNGNGKCVQPN-ECICDSNWTGQLC 1069
                  678********888.***********99 PP

  == domain 11  score: 9.0 bits;  conditional E-value: 0.00098
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+  G Cv ++  C C +g+ G +C
  EFC37620.1 1082 ISVCSRKGDCVGAN-LCICLTGWGGEDC 1108
                  678********666.8************ PP

  == domain 12  score: 16.1 bits;  conditional E-value: 6.1e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+ghG C +++ qC C+ ++ Gk+C
  EFC37620.1 1136 TLVCSGHGECTSPN-QCNCNLNWGGKQC 1162
                  578********999.************* PP

  == domain 13  score: 17.0 bits;  conditional E-value: 3.2e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ +G+Cvn++ qC+C+  + G  C
  EFC37620.1 1175 EAVCNSRGYCVNEN-QCQCNEMWGGQFC 1201
                  778*******9888.***********99 PP

  == domain 14  score: 17.8 bits;  conditional E-value: 1.7e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+  G+Cv ++ qC+C sg+ Gk C
  EFC37620.1 1214 SNVCNSLGVCVGPN-QCKCLSGWGGKLC 1240
                  689********888.************9 PP

  == domain 15  score: 27.3 bits;  conditional E-value: 1.9e-09
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C a +++C+g+G+C++++ +C+Cd g++G+ C
  EFC37620.1 1257 CIAKSNACSGNGKCIDLN-RCKCDKGWTGPLC 1287
                  6667899*******9999.************9 PP

  == domain 16  score: 7.4 bits;  conditional E-value: 0.0032
       EGF_2    7 iCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                   C+g   G+Cv+   +C+C+sgy  + C
  EFC37620.1 1302 VCNGfgVGVCVDXD-KCECFSGYGDAFC 1328
                  59986677888777.9*******77777 PP

  == domain 17  score: 17.2 bits;  conditional E-value: 2.8e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G+C  ++ +C+C++++ G  C
  EFC37620.1 1347 VCSGRGVCLGPN-KCVCEPNWGGFMC 1371
                  5********888.********99777 PP

  == domain 18  score: 6.3 bits;  conditional E-value: 0.0071
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   +C g+G C++    C+C +gy G +C
  EFC37620.1 1385 GACFGNGDCIAVD-SCKCYQGYIGYDC 1410
                  579******9777.6**********99 PP

  == domain 19  score: 0.2 bits;  conditional E-value: 0.57
       EGF_2    1 Csas..deiCgghGt 13  
                  C++   d++Cgg G+
  EFC37620.1 1410 CRTVapDNNCGGSGS 1424
                  999999******997 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.0    0.0044       7.9      51      78 ..     176     202 ..     166     207 .. 0.85
   2 !    9.2   0.0   0.00077       1.4      49      78 ..     230     258 ..     222     263 .. 0.87
   3 ?    3.8   0.0     0.036        65      51      78 ..     288     314 ..     280     320 .. 0.85
   4 !    5.9   0.0    0.0081        14      49      78 ..     343     372 ..     335     376 .. 0.91
   5 !    6.8   0.0    0.0044       7.9      51      78 ..     571     597 ..     561     602 .. 0.85
   6 !    9.2   0.0   0.00077       1.4      49      78 ..     625     653 ..     617     658 .. 0.87
   7 ?    3.8   0.0     0.036        65      51      78 ..     683     709 ..     675     715 .. 0.85
   8 !    5.9   0.0    0.0081        14      49      78 ..     738     767 ..     730     771 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0044
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   ++l+s+nG+ i+++   iy+ad l++ i
    EFC37620.1 176 AKLNSPNGLSISQNG-EIYIADTLNHRI 202
                   5799*******9877.59********98 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00077
  Arylesterase  49 vasglssanGInidadkkyiyvadilresi 78 
                   v s+l+s+nG+ i+++   iy+ad l++ i
    EFC37620.1 230 VLSQLNSPNGVHISQNG-EIYIADTLNHRI 258
                   7899*********9877.59********98 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.036
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   s+l+s+ G+ ++++   iy+ad l++ i
    EFC37620.1 288 SQLNSPYGVHVSQNG-EIYIADTLNHRI 314
                   7899*******9876.59********98 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.0081
  Arylesterase  49 vasglssanGInidadkkyiyvadilresi 78 
                    as+l+s+ G+ +++++  i +ad  ++ i
    EFC37620.1 343 IASRLNSPKGVFVSPNNNEILIADTSNNRI 372
                   699*********************999887 PP

  == domain 5  score: 6.8 bits;  conditional E-value: 0.0044
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   ++l+s+nG+ i+++   iy+ad l++ i
    EFC37620.1 571 AKLNSPNGLSISQNG-EIYIADTLNHRI 597
                   5799*******9877.59********98 PP

  == domain 6  score: 9.2 bits;  conditional E-value: 0.00077
  Arylesterase  49 vasglssanGInidadkkyiyvadilresi 78 
                   v s+l+s+nG+ i+++   iy+ad l++ i
    EFC37620.1 625 VLSQLNSPNGVHISQNG-EIYIADTLNHRI 653
                   7899*********9877.59********98 PP

  == domain 7  score: 3.8 bits;  conditional E-value: 0.036
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   s+l+s+ G+ ++++   iy+ad l++ i
    EFC37620.1 683 SQLNSPYGVHVSQNG-EIYIADTLNHRI 709
                   7899*******9876.59********98 PP

  == domain 8  score: 5.9 bits;  conditional E-value: 0.0081
  Arylesterase  49 vasglssanGInidadkkyiyvadilresi 78 
                    as+l+s+ G+ +++++  i +ad  ++ i
    EFC37620.1 738 IASRLNSPKGVFVSPNNNEILIADTSNNRI 767
                   699*********************999887 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.0     1e-08   1.8e-05      83     217 ..     176     324 ..     171     328 .. 0.78
   2 ?    0.5   0.0       0.2   3.6e+02     130     160 ..     344     374 ..     341     381 .. 0.89
   3 !   24.7   0.0   8.4e-09   1.5e-05      82     218 ..     570     720 ..     558     726 .. 0.79
   4 ?    0.5   0.0       0.2   3.7e+02     130     160 ..     739     769 ..     736     773 .. 0.89

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 1e-08
         SGL  83 kpllrfNDgvvdpdGrlwfGtmgdeeakgeev.galyrldpdgk.......lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsn. 172
                  +l+++N + ++++G++++ +  +++ ++ +  g +  + + g+          vl++l+ pNG+++s+ g+ +Y+aD+l+++i +++     +++   
  EFC37620.1 176 AKLNSPNGLSISQNGEIYIADTLNHRIRKINSyGVISTIAGTGRasfggdgGFAVLSQLNSPNGVHISQNGE-IYIADTLNHRIRKINSYGVISTVAGt 273
                 5789****************999888888766777777777755455555567899************9875.799*******9998765444444330 PP

         SGL 173 rrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGkli 217
                  r  + ++ g       + p G+ v ++G++++A   +++++++  +G+++
  EFC37620.1 274 GRASFGGDGGLainsqlNSPYGVHVSQNGEIYIADTLNHRIRKIFVNGTIT 324
                 3333444444499998877************************99999876 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.2
         SGL 130 lddltipNGlawspdgktlYlaDsltrkiwa 160
                 +++l+ p G+ +sp ++ +++aD+ +++i +
  EFC37620.1 344 ASRLNSPKGVFVSPNNNEILIADTSNNRIRK 374
                 56788999********************986 PP

  == domain 3  score: 24.7 bits;  conditional E-value: 8.4e-09
         SGL  82 ekpllrfNDgvvdpdGrlwfGtmgdeeakgeev.galyrldpdgk.......lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsn 172
                 + +l+++N + ++++G++++ +  +++ ++ +  g +  + + g+          vl++l+ pNG+++s+ g+ +Y+aD+l+++i +++     +++  
  EFC37620.1 570 RAKLNSPNGLSISQNGEIYIADTLNHRIRKINSyGVISTIAGTGRasfggdgGFAVLSQLNSPNGVHISQNGE-IYIADTLNHRIRKINSYGVISTVAG 667
                 45899****************999888888766777777777755455555567899************9875.799*******999876544444433 PP

         SGL 173 .rrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                   r  + ++ g       + p G+ v ++G++++A   +++++++  +G++++
  EFC37620.1 668 tGRASFGGDGGLainsqlNSPYGVHVSQNGEIYIADTLNHRIRKIFVNGTITT 720
                 03333444444499998877************************999998765 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.2
         SGL 130 lddltipNGlawspdgktlYlaDsltrkiwa 160
                 +++l+ p G+ +sp ++ +++aD+ +++i +
  EFC37620.1 739 ASRLNSPKGVFVSPNNNEILIADTSNNRIRK 769
                 56788999********************986 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.055        99      55      82 ..     177     203 ..     175     211 .. 0.79
   2 !    5.7   0.0    0.0091        16      52      82 ..     230     259 ..     226     264 .. 0.80
   3 ?    2.6   0.0     0.083   1.5e+02      54      88 ..     288     321 ..     284     322 .. 0.84
   4 !    7.6   0.0    0.0023       4.2      52      83 ..     343     374 ..     341     378 .. 0.91
   5 ?    3.2   0.0     0.055        99      55      82 ..     572     598 ..     570     606 .. 0.79
   6 !    5.7   0.0    0.0091        16      52      82 ..     625     654 ..     621     659 .. 0.80
   7 ?    2.6   0.0     0.083   1.5e+02      54      88 ..     683     716 ..     679     717 .. 0.84
   8 !    7.7   0.0    0.0022       3.9      52      83 ..     738     769 ..     736     774 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.055
   Str_synth  55 kLyfanGialsedgsfvlvcetamkris 82 
                 kL  +nG+++s++g+  + ++t  +ri 
  EFC37620.1 177 KLNSPNGLSISQNGEIYI-ADTLNHRIR 203
                 7999*********99766.566666655 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0091
   Str_synth  52 lldkLyfanGialsedgsfvlvcetamkris 82 
                 +l++L  +nG+ +s++g+  + ++t  +ri 
  EFC37620.1 230 VLSQLNSPNGVHISQNGEIYI-ADTLNHRIR 259
                 6899*************9766.566666655 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.083
   Str_synth  54 dkLyfanGialsedgsfvlvcetamkrisrywike 88 
                 ++L  + G+ +s++g+  + ++t  +ri + ++++
  EFC37620.1 288 SQLNSPYGVHVSQNGEIYI-ADTLNHRIRKIFVNG 321
                 789999*********9765.799999999999886 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.0023
   Str_synth  52 lldkLyfanGialsedgsfvlvcetamkrisr 83 
                 ++++L  + G+ +s++++ +l+++t+ +ri +
  EFC37620.1 343 IASRLNSPKGVFVSPNNNEILIADTSNNRIRK 374
                 6899*************************876 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.055
   Str_synth  55 kLyfanGialsedgsfvlvcetamkris 82 
                 kL  +nG+++s++g+  + ++t  +ri 
  EFC37620.1 572 KLNSPNGLSISQNGEIYI-ADTLNHRIR 598
                 7999*********99766.566666655 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.0091
   Str_synth  52 lldkLyfanGialsedgsfvlvcetamkris 82 
                 +l++L  +nG+ +s++g+  + ++t  +ri 
  EFC37620.1 625 VLSQLNSPNGVHISQNGEIYI-ADTLNHRIR 654
                 6899*************9766.566666655 PP

  == domain 7  score: 2.6 bits;  conditional E-value: 0.083
   Str_synth  54 dkLyfanGialsedgsfvlvcetamkrisrywike 88 
                 ++L  + G+ +s++g+  + ++t  +ri + ++++
  EFC37620.1 683 SQLNSPYGVHVSQNGEIYI-ADTLNHRIRKIFVNG 716
                 789999*********9765.799999999999886 PP

  == domain 8  score: 7.7 bits;  conditional E-value: 0.0022
   Str_synth  52 lldkLyfanGialsedgsfvlvcetamkrisr 83 
                 ++++L  + G+ +s++++ +l+++t+ +ri +
  EFC37620.1 738 IASRLNSPKGVFVSPNNNEILIADTSNNRIRK 769
                 6899*************************876 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   2.8       2.4   4.2e+03       6      12 ..     409     415 ..     390     424 .. 0.77
   2 ?    2.1   0.1      0.14   2.6e+02      19      31 ..     772     784 ..     767     785 .. 0.83
   3 ?   -3.8   7.1       9.7   1.7e+04       4      31 ..     797     823 ..     791     824 .. 0.82
   4 !   10.0   3.9   0.00046      0.83       4      31 ..     837     862 ..     835     863 .. 0.89
   5 ?    4.3   4.5     0.029        53       6      31 ..     880     901 ..     869     902 .. 0.88
   6 ?    0.4   2.2      0.46   8.3e+02       6      25 ..     919     934 ..     913     941 .. 0.77
   7 !    8.0   7.1     0.002       3.6       4      31 ..     954     979 ..     947     980 .. 0.85
   8 !    9.3   2.0   0.00077       1.4       6      31 ..    1007    1028 ..    1000    1029 .. 0.86
   9 !   12.0   3.4   0.00011      0.19       5      30 ..    1043    1066 ..    1040    1068 .. 0.87
  10 ?    1.7   1.0      0.19   3.4e+02      22      31 ..    1097    1106 ..    1088    1107 .. 0.92
  11 ?    4.1   5.1     0.032        58       4      31 ..    1134    1160 ..    1132    1161 .. 0.82
  12 ?    3.9   3.0     0.039        70       5      26 ..    1174    1194 ..    1171    1199 .. 0.83
  13 !    7.6   2.1    0.0027       4.8       3      31 ..    1214    1238 ..    1212    1239 .. 0.80
  14 !   17.7   2.2   1.8e-06    0.0033       3      31 ..    1261    1285 ..    1259    1286 .. 0.91
  15 ?    4.6   1.8     0.023        41       6      29 ..    1303    1324 ..    1296    1327 .. 0.83
  16 ?    2.2   1.8      0.13   2.3e+02       6      30 ..    1348    1368 ..    1342    1368 .. 0.86
  17 ?    5.1   6.1     0.016        28       5      30 ..    1385    1407 ..    1376    1407 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2.4
                 STTT-EE CS
         EGF   6 CsngGtC 12 
                 C+++G+C
  EFC37620.1 409 CNGNGIC 415
                 9****** PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.14
                 EEEEEECTTEEST CS
         EGF  19 gytCiCpeGytGk 31 
                 +y+C C++ + G 
  EFC37620.1 772 EYICNCTSEWGGQ 784
                 7******999885 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 9.7
                 TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np...CsngGtCvdtgrggytCiCpeGytGk 31 
                 n+   C ++G C+++     +C+C + y G+
  EFC37620.1 797 NNisaCEGHGNCISPN----ICECNSTYGGE 823
                 66777*******9999....****8877665 PP

  == domain 4  score: 10.0 bits;  conditional E-value: 0.00046
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +p  C ++G+C+++     +CiC + +tG 
  EFC37620.1 837 DPyvCTGNGECIQPD----ECICNTNWTGQ 862
                 5666***********....*********95 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.029
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+++G Cv++     +C+C + ++G+
  EFC37620.1 880 CNGNGQCVSPN----ICECNSSWSGE 901
                 ***********....******99997 PP

  == domain 6  score: 0.4 bits;  conditional E-value: 0.46
                 STTT-EEEEETTTEEEEEEC CS
         EGF   6 CsngGtCvdtgrggytCiCp 25 
                 Cs++G C     g   C+C 
  EFC37620.1 919 CSGNGAC----IGPDVCECN 934
                 *******....456699996 PP

  == domain 7  score: 8.0 bits;  conditional E-value: 0.002
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +p  C+++G+C+++     +CiC + +tG+
  EFC37620.1 954 DPyvCNGNGECFQPN----ECICNSNWTGP 979
                 5677*******8888....9*********7 PP

  == domain 8  score: 9.3 bits;  conditional E-value: 0.00077
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs++G C+++     +C C + ++G 
  EFC37620.1 1007 CSGNGLCIRPD----ECLCNSNWAGQ 1028
                  ***********....********996 PP

  == domain 9  score: 12.0 bits;  conditional E-value: 0.00011
                  T..STTT-EEEEETTTEEEEEECTTEES CS
         EGF    5 p..CsngGtCvdtgrggytCiCpeGytG 30  
                     C+++G+Cv++     +CiC++ +tG
  EFC37620.1 1043 EtaCNGNGKCVQPN----ECICDSNWTG 1066
                  346***********....*********9 PP

  == domain 10  score: 1.7 bits;  conditional E-value: 0.19
                  EEECTTEEST CS
         EGF   22 CiCpeGytGk 31  
                  CiC +G+ G+
  EFC37620.1 1097 CICLTGWGGE 1106
                  ********98 PP

  == domain 11  score: 4.1 bits;  conditional E-value: 0.032
                  TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np...CsngGtCvdtgrggytCiCpeGytGk 31  
                  n+   Cs++G+C ++     +C C   + Gk
  EFC37620.1 1134 NNtlvCSGHGECTSPN----QCNCNLNWGGK 1160
                  44588*******6666....9****999998 PP

  == domain 12  score: 3.9 bits;  conditional E-value: 0.039
                  T...STTT-EEEEETTTEEEEEECT CS
         EGF    5 p...CsngGtCvdtgrggytCiCpe 26  
                  +   C+ +G Cv+      +C+C e
  EFC37620.1 1174 NeavCNSRGYCVNEN----QCQCNE 1194
                  4577*******9999....9***75 PP

  == domain 13  score: 7.6 bits;  conditional E-value: 0.0027
                  STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGk 31  
                  +n C+  G Cv +     +C+C +G+ Gk
  EFC37620.1 1214 SNVCNSLGVCVGP----NQCKCLSGWGGK 1238
                  466*******433....47********98 PP

  == domain 14  score: 17.7 bits;  conditional E-value: 1.8e-06
                  STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGk 31  
                  +n Cs++G+C+d+     +C+C+ G+tG+
  EFC37620.1 1261 SNACSGNGKCIDLN----RCKCDKGWTGP 1285
                  466***********....**********7 PP

  == domain 15  score: 4.6 bits;  conditional E-value: 0.023
                  STTT-E..EEEETTTEEEEEECTTEE CS
         EGF    6 CsngGt..CvdtgrggytCiCpeGyt 29  
                  C++ G   Cvd      +C+C +Gy 
  EFC37620.1 1303 CNGFGVgvCVDXD----KCECFSGYG 1324
                  77777777*****....*******96 PP

  == domain 16  score: 2.2 bits;  conditional E-value: 0.13
                  STTT-EEEEETTTEEEEEECTTEES CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytG 30  
                  Cs++G C     g  +C C + + G
  EFC37620.1 1348 CSGRGVC----LGPNKCVCEPNWGG 1368
                  *******....56778*****9977 PP

  == domain 17  score: 5.1 bits;  conditional E-value: 0.016
                  T.STTT-EEEEETTTEEEEEECTTEES CS
         EGF    5 p.CsngGtCvdtgrggytCiCpeGytG 30  
                    C ++G C+ +     +C+C +Gy G
  EFC37620.1 1385 GaCFGNGDCIAVD----SCKCYQGYIG 1407
                  25***********....********98 PP

>> DUF4485  Domain of unknown function (DUF4485)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0      0.04        72      49      70 ..      78      99 ..      63     101 .. 0.88
   2 ?    5.6   0.0    0.0093        17      47      70 ..     471     494 ..     457     496 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.04
     DUF4485 49 RNdYlqlLlkmlqngrlegPFn 70
                 N+Y   L+  +qngr++++F 
  EFC37620.1 78 NNNYTETLIVDTQNGRIRKIFM 99
                69*******************5 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0093
     DUF4485  47 knRNdYlqlLlkmlqngrlegPFn 70 
                  n N+Y   L++ +qngr++++F 
  EFC37620.1 471 LNNNNYTETLIIDTQNGRIRKIFM 494
                 578********************5 PP

>> MBG_2  MBG domain (YGX type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   2.2    0.0081        14      36      65 ..      51      84 ..      20      91 .. 0.75
   2 ?    8.5   1.0    0.0017       3.1      36      65 ..     448     479 ..     414     487 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0081
       MBG_2 36 t....gtlsrtagenvGtYaitasglsssNYtit 65
                +    g l+ +a+ n  +Y+i++s ls++NYt t
  EFC37620.1 51 GmegdGGLAINAQLNSPSYSISISPLSNNNYTET 84
                24455778888888999**************977 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0017
       MBG_2  36 t..gtlsrtagenvGtYaitasglsssNYtit 65 
                 +  g l+ +a+ n+ +Y+i++s l+++NYt t
  EFC37620.1 448 EgdGGLAINAQLNAPSYSISISPLNNNNYTET 479
                 155888999999*****************976 PP

>> NAGLU_N  Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.19   3.4e+02      59      77 ..     771     789 ..     750     791 .. 0.88
   2 ?   -0.5   0.0      0.61   1.1e+03      61      77 ..     890     906 ..     889     907 .. 0.91
   3 ?   -1.9   0.1       1.7     3e+03      62      78 ..     930     946 ..     929     947 .. 0.88
   4 ?    4.1   0.1     0.021        38      61      78 ..    1149    1166 ..    1148    1167 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.19
                 HHHHS--B--TT--B---- CS
     NAGLU_N  59 LkyycgvhiswngdqlklP 77 
                 ++y+c++   w g+ +++P
  EFC37620.1 771 IEYICNCTSEWGGQYCEIP 789
                 579*************998 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.61
                 HHS--B--TT--B---- CS
     NAGLU_N  61 yycgvhiswngdqlklP 77 
                 ++c+++ sw+g+ +++P
  EFC37620.1 890 NICECNSSWSGELCEIP 906
                 68**********99988 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.7
                 HS--B--TT--B----S CS
     NAGLU_N  62 ycgvhiswngdqlklPa 78 
                 +c+++ +w g+ ++ P+
  EFC37620.1 930 VCECNSTWGGQYCESPK 946
                 8**********999885 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.021
                  HHS--B--TT--B----S CS
     NAGLU_N   61 yycgvhiswngdqlklPa 78  
                  + c++++ w g+q+++P+
  EFC37620.1 1149 NQCNCNLNWGGKQCEIPK 1166
                  57**************96 PP

>> DUF3487  Protein of unknown function (DUF3487)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       2.2     4e+03      18      35 ..    1293    1310 ..    1289    1312 .. 0.85
   2 ?    9.0   2.1   0.00067       1.2       4      54 ..    1513    1565 ..    1510    1579 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.2
     DUF3487   18 rGltadEllvlaglglvv 35  
                   G +a+El v+ g+g+ v
  EFC37620.1 1293 NGTSATELTVCNGFGVGV 1310
                  699********9999865 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00067
     DUF3487    4 eflpdrLnrePvVfrGltadEllvla.glglvvglvl.glllallvgslalip 54  
                  +f+   L   P +f G+t++ +++++ ++g+v+ l++  +ll ll  +++l++
  EFC37620.1 1513 DFISWLLTYLPKIFSGVTTQQVATVLiVIGVVILLIIiCVLLYLLSPYVTLVL 1565
                  6888889999***********98765378888877651555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1584 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1049  (0.0585086); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.04u 0.34s 00:00:01.38 Elapsed: 00:00:00.55
# Mc/sec: 8627.16
//
Query:       EFC37621.1  [L=1034]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-55  183.1 427.6    9.3e-05   22.7  15.0   22.4 22  EGF_2     EGF-like domain
    9.8e-12   44.3   0.0    6.9e-05   22.7   0.0    6.1  4  NHL       NHL repeat
     0.0059   16.9   4.3     0.0059   16.9   4.3   25.3 22  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   2.2   0.00022       1.3      20      32 .]     281     293 ..     269     293 .. 0.92
   2 !   15.0   9.5   3.9e-06     0.023       6      32 .]     306     333 ..     301     333 .. 0.91
   3 !   18.1   9.4   4.3e-07    0.0026       5      32 .]     345     371 ..     338     371 .. 0.84
   4 !   17.1  10.7   9.1e-07    0.0055       5      32 .]     376     403 ..     372     403 .. 0.91
   5 !   17.0  16.8   9.5e-07    0.0057       1      32 []     408     442 ..     408     442 .. 0.95
   6 !   15.7  13.5   2.5e-06     0.015       1      32 []     447     474 ..     445     474 .. 0.92
   7 ?    3.5   9.9     0.016        96      13      32 .]     488     506 ..     479     506 .. 0.89
   8 !   13.7  17.8     1e-05     0.062       1      32 []     511     537 ..     511     537 .. 0.87
   9 !    6.3  17.1    0.0021        13       1      32 []     542     569 ..     542     569 .. 0.93
  10 !   20.2  12.7   9.3e-08   0.00056       1      32 []     574     601 ..     574     601 .. 0.96
  11 !   16.0  13.5   1.9e-06     0.012       1      28 [.     606     629 ..     606     635 .. 0.89
  12 !   22.7  15.0   1.6e-08   9.3e-05       1      32 []     640     667 ..     640     667 .. 0.93
  13 !   18.3  12.8   3.8e-07    0.0023       1      32 []     672     706 ..     672     706 .. 0.95
  14 !   16.1  14.4   1.9e-06     0.011       1      32 []     711     738 ..     711     738 .. 0.95
  15 !   20.5  10.6   7.7e-08   0.00046       1      32 []     743     770 ..     743     770 .. 0.94
  16 !    5.3   7.1    0.0043        25       1      27 [.     775     796 ..     773     798 .. 0.82
  17 !   16.7   4.9   1.2e-06    0.0071       5      32 .]     798     826 ..     797     826 .. 0.94
  18 !   13.0  12.5   1.7e-05       0.1       1      32 []     831     860 ..     831     860 .. 0.89
  19 !   16.2  11.1   1.7e-06      0.01       1      32 []     865     899 ..     865     899 .. 0.93
  20 !   14.8  12.6   4.6e-06     0.028       1      32 []     904     933 ..     904     933 .. 0.86
  21 !   11.9  12.2   3.7e-05      0.22       4      32 .]     941     971 ..     938     971 .. 0.89
  22 !   10.6  13.8   9.3e-05      0.56       1      32 []     976    1005 ..     976    1005 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00022
       EGF_2  20 qCdCdsgyqGktC 32 
                 qC+C sg+ G +C
  EFC37621.1 281 QCHCISGWDGTYC 293
                 8************ PP

  == domain 2  score: 15.0 bits;  conditional E-value: 3.9e-06
       EGF_2   6 eiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                  +Cgg   G C +++ +C C++gy+G +C
  EFC37621.1 306 GACGGssKGDCTSPN-KCTCKNGYYGSDC 333
                 4799999*****999.************* PP

  == domain 3  score: 18.1 bits;  conditional E-value: 4.3e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +C ghGtC+++   C+Cd+gy+G  C
  EFC37621.1 345 SIDCYGHGTCIAPS-TCSCDAGYSGYFC 371
                 668********888.9*********999 PP

  == domain 4  score: 17.1 bits;  conditional E-value: 9.1e-07
       EGF_2   5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 + +C+ghG+C  ++  C+C  +g+ G +C
  EFC37621.1 376 CPDCHGHGVCTGPN-TCYClTAGWKGSDC 403
                 456********888.9************* PP

  == domain 5  score: 17.0 bits;  conditional E-value: 9.5e-07
       EGF_2   1 Csas..deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 C  +  d++C+g  +G+C ++ G C+C+sg++G++C
  EFC37621.1 408 CFGNsqDSACSGptNGKCTSPDG-CSCNSGWTGNNC 442
                 7777789****************.************ PP

  == domain 6  score: 15.7 bits;  conditional E-value: 2.5e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C ++   C+g+G Cv ++  C+C sg+ G +C
  EFC37621.1 447 CTNN---CNGRGECVGPN-TCSCISGWGGVDC 474
                 7766...********888.9************ PP

  == domain 7  score: 3.5 bits;  conditional E-value: 0.016
       EGF_2  13 tCvnqcGqCdCdsgyqGktC 32 
                 +C  ++  C C sgy+G++C
  EFC37621.1 488 YCAGPN-TCACISGYSGPNC 506
                 688777.9************ PP

  == domain 8  score: 13.7 bits;  conditional E-value: 1e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 Cs +   Cg +G+C +  G C C++g++G++C
  EFC37621.1 511 CSGG---CG-NGYCSS-PGTCTCNPGWTGADC 537
                 8877...97.6***94.46************* PP

  == domain 9  score: 6.3 bits;  conditional E-value: 0.0021
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C ++   C+ h +C  ++  C C++gy+G++C
  EFC37621.1 542 CTNG---CNSHQQCTGPN-TCTCNAGYSGPNC 569
                 8877...********888.9************ PP

  == domain 10  score: 20.2 bits;  conditional E-value: 9.3e-08
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 Cs++   C+ghG Cv+++  C C s ++G +C
  EFC37621.1 574 CSNN---CNGHGMCVAPN-TCACYSRWSGSDC 601
                 9987...********999.9************ PP

  == domain 11  score: 16.0 bits;  conditional E-value: 1.9e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyq 28 
                 C ++   C+ghGtCv ++ +C+C+sg+ 
  EFC37621.1 606 CDTG---CNGHGTCVGPN-VCVCNSGWA 629
                 8887...********888.********6 PP

  == domain 12  score: 22.7 bits;  conditional E-value: 1.6e-08
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C+++   C+ghGtC+ ++  C C+sg++G +C
  EFC37621.1 640 CPND---CSGHGTCDGPN-SCTCNSGWTGLDC 667
                 8876...********888.7***********9 PP

  == domain 13  score: 18.3 bits;  conditional E-value: 3.8e-07
       EGF_2   1 Csas..deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 C  +  d++C+g  +G+C ++  +C+C+sg++G++C
  EFC37621.1 672 CFGNtqDLACSGptNGKCTSPD-VCSCNSGWTGNNC 706
                 8888889************999.************* PP

  == domain 14  score: 16.1 bits;  conditional E-value: 1.9e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C ++   Cg +G+C +++  C C++g+ G +C
  EFC37621.1 711 CTNG---CGSNGVCTAPN-TCTCNDGWMGSDC 738
                 8877...********999.9************ PP

  == domain 15  score: 20.5 bits;  conditional E-value: 7.7e-08
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C++    C+ hG+Cv++   C+C +g++G++C
  EFC37621.1 743 CPNQ---CSAHGKCVSPA-ICSCTAGWTGNDC 770
                 8865...********999.9************ PP

  == domain 16  score: 5.3 bits;  conditional E-value: 0.0043
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgy 27 
                 C ++   C  +G+C +++  C C+ g+
  EFC37621.1 775 CTSG---CL-QGSCTSPN-TCTCKEGW 796
                 5444...65.8****999.9******9 PP

  == domain 17  score: 16.7 bits;  conditional E-value: 1.2e-06
       EGF_2   5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 d++C+g  hG+C ++   C C s ++G++C
  EFC37621.1 798 DLACSGptHGKCLSPD-ACNCTSEWTGPQC 826
                 578**********999.8************ PP

  == domain 18  score: 13.0 bits;  conditional E-value: 1.7e-05
       EGF_2   1 CsasdeiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 C ++   Cg+  +G Cv+++  C+C+ g++G +C
  EFC37621.1 831 CING---CGNsnQGLCVAPN-TCECKEGWTGTDC 860
                 6665...88888*****999.9************ PP

  == domain 19  score: 16.2 bits;  conditional E-value: 1.7e-06
       EGF_2   1 Csas..deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 C  +  d+ C+g  hG+Cv++  +CdC s ++G +C
  EFC37621.1 865 CFGNsqDSSCNGptHGKCVDLA-VCDCTSEWTGSQC 899
                 77777899***********999.************* PP

  == domain 20  score: 14.8 bits;  conditional E-value: 4.6e-06
       EGF_2   1 Csas.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C+++ +   +++G Cv+++  C+C+ g++G++C
  EFC37621.1 904 CKSGcG--SSNQGLCVAPN-TCECKEGWTGADC 933
                 888733..456*****999.9************ PP

  == domain 21  score: 11.9 bits;  conditional E-value: 3.7e-05
       EGF_2   4 s..deiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                    d++C+g +G+Cv++   C C s ++G  C
  EFC37621.1 941 KtqDSACNGtNGKCVSPD-ACNCTSEWTGSEC 971
                 555999*********999.8************ PP

  == domain 22  score: 10.6 bits;  conditional E-value: 9.3e-05
       EGF_2    1 CsasdeiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  C ++   Cg+  +G Cv ++  C+C+ g++Gk+C
  EFC37621.1  976 CING---CGNsnQGLCVGPN-ICRCKEGWTGKNC 1005
                  6665...88888*****888.9************ PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   1.1e-08   6.9e-05       1      27 [.      58      84 ..      58      85 .. 0.95
   2 ?    3.4   0.0     0.015        88       1      19 [.     111     129 ..     111     136 .. 0.83
   3 !    8.2   0.0   0.00046       2.7       1      26 [.     168     193 ..     168     195 .. 0.85
   4 ?    1.8   0.0      0.05     3e+02       1      22 [.     221     242 ..     221     246 .. 0.90

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 1.1e-08
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +n+P Gv+++++G+iy+aD  nhr+++
  EFC37621.1 58 LNSPLGVSMSKGGEIYIADKLNHRIRK 84
                799**********************97 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.015
                 BSSEEEEEEETTTEEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaD 19 
                 +n P+G+ +d n++i++a+
  EFC37621.1 111 LNGPAGIFLDENDNIFIAE 129
                 799*******999999997 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00046
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n P+ v ++ +G ++++D++nh ++
  EFC37621.1 168 LNGPEAVILSGTGAVIISDTYNHAIR 193
                 577777788889***********996 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.05
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 ++yP G+++++   +++aDs n
  EFC37621.1 221 LYYPMGLTITPYQALLIADSWN 242
                 68999**************998 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   2.3     0.032   1.9e+02       6      31 ..     261     291 ..     257     292 .. 0.68
   2 ?    3.8   2.2     0.012        73      21      31 ..     321     331 ..     314     332 .. 0.89
   3 !   11.2   6.6   5.8e-05      0.35       6      30 ..     348     368 ..     337     368 .. 0.90
   4 ?   -2.3  12.0      0.97   5.8e+03       1      31 [.     371     401 ..     371     402 .. 0.75
   5 ?    3.8   2.2     0.012        72      10      32 .]     423     441 ..     421     441 .. 0.73
   6 ?   -5.7  16.0         3   1.8e+04       1      30 [.     447     471 ..     447     487 .. 0.73
   7 ?    0.9   1.8       0.1   6.1e+02      21      32 .]     494     505 ..     489     505 .. 0.91
   8 ?    3.4  13.4     0.016        95       5      31 ..     509     535 ..     506     536 .. 0.77
   9 ?   -0.8  16.1      0.33     2e+03       1      32 []     537     568 ..     537     568 .. 0.81
  10 !    8.1   7.2   0.00054       3.2       1      31 [.     574     599 ..     574     600 .. 0.94
  11 ?   -1.1  11.0      0.41   2.5e+03       1      28 [.     606     628 ..     601     630 .. 0.75
  12 !    6.5  14.4    0.0017        10       1      31 [.     640     665 ..     635     666 .. 0.84
  13 !    6.7   1.4    0.0015         9       9      32 .]     686     705 ..     685     705 .. 0.85
  14 ?   -3.9  11.8         3   1.8e+04       1      30 [.     711     735 ..     706     737 .. 0.72
  15 !   16.9   4.3   9.9e-07    0.0059       1      31 [.     743     768 ..     739     769 .. 0.92
  16 ?   -0.2   7.5      0.22   1.3e+03       6      29 ..     775     797 ..     770     799 .. 0.72
  17 !    4.7   0.8    0.0065        39       9      31 ..     806     824 ..     805     825 .. 0.90
  18 !    5.7   8.3    0.0032        19       7      30 ..     838     857 ..     826     859 .. 0.82
  19 !    7.7   0.4   0.00072       4.3       9      31 ..     879     897 ..     878     898 .. 0.93
  20 !    8.6   5.7    0.0004       2.4       7      31 ..     911     931 ..     904     932 .. 0.93
  21 ?    3.0   3.1     0.022   1.3e+02       9      31 ..     951     969 ..     947     970 .. 0.92
  22 !    4.7   8.8    0.0065        39       5      32 .]     974    1004 ..     971    1004 .. 0.68

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.032
                 STTT-E..EEEET.TT..EEEEEECTTEEST CS
         EGF   6 CsngGt..Cvdtg.rg..gytCiCpeGytGk 31 
                 C+n +   Cv++  r+    +C+C +G++G 
  EFC37621.1 261 CNNFAMacCVNVIdRNpfATQCHCISGWDGT 291
                 888888866555543311558*******995 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.012
                 EEEECTTEEST CS
         EGF  21 tCiCpeGytGk 31 
                 +C+C++Gy G+
  EFC37621.1 321 KCTCKNGYYGS 331
                 6********97 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 5.8e-05
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 C ++GtC+ ++    tC C+ Gy+G
  EFC37621.1 348 CYGHGTCIAPS----TCSCDAGYSG 368
                 ***********....********99 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 0.97
                 GCSTT...STTT-EEEEETTTEEEEEEC.TTEEST CS
         EGF   1 Cspnp...CsngGtCvdtgrggytCiCp.eGytGk 31 
                 C++ p   C+++G C     g  tC C   G++G+
  EFC37621.1 371 CDQFPcpdCHGHGVC----TGPNTCYCLtAGWKGS 401
                 77744449*******....5567888887888775 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.012
                 -EEEEETTTEEEEEECTTEESTT CS
         EGF  10 GtCvdtgrggytCiCpeGytGkr 32 
                 G+C ++      C C +G+tG++
  EFC37621.1 423 GKCTSPD----GCSCNSGWTGNN 441
                 6673333....4*********86 PP

  == domain 6  score: -5.7 bits;  conditional E-value: 3
                 GCSTTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGytG 30 
                 C+ n+C+++G+Cv +     tC C +G+ G
  EFC37621.1 447 CT-NNCNGRGECVGP----NTCSCISGWGG 471
                 77.99*******333....37777666665 PP

  == domain 7  score: 0.9 bits;  conditional E-value: 0.1
                 EEEECTTEESTT CS
         EGF  21 tCiCpeGytGkr 32 
                 tC C +Gy+G++
  EFC37621.1 494 TCACISGYSGPN 505
                 8*********86 PP

  == domain 8  score: 3.4 bits;  conditional E-value: 0.016
                 T.STTT-EEEEET.TTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtg.rggytCiCpeGytGk 31 
                 p Cs+g  C ++  +   tC+C +G+tG+
  EFC37621.1 509 PvCSGG--CGNGYcSSPGTCTCNPGWTGA 535
                 667666..7777778888**********7 PP

  == domain 9  score: -0.8 bits;  conditional E-value: 0.33
                 GCSTTSTTT-EEEEET..TTEEEEEECTTEESTT CS
         EGF   1 CspnpCsngGtCvdtg..rggytCiCpeGytGkr 32 
                 Cs  +C ng  C + +   g  tC+C  Gy+G++
  EFC37621.1 537 CSTFTCTNG--CNSHQqcTGPNTCTCNAGYSGPN 568
                 777777777..77777779999**********86 PP

  == domain 10  score: 8.1 bits;  conditional E-value: 0.00054
                 GCSTTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs n+C+++G Cv +     tC C + ++G+
  EFC37621.1 574 CS-NNCNGHGMCVAPN----TCACYSRWSGS 599
                 77.9************....********996 PP

  == domain 11  score: -1.1 bits;  conditional E-value: 0.41
                 GCSTTSTTT-EEEEETTTEEEEEECTTE CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGy 28 
                 C+ + C+++GtCv +      C C +G+
  EFC37621.1 606 CD-TGCNGHGTCVGP----NVCVCNSGW 628
                 43.45*******333....369999998 PP

  == domain 12  score: 6.5 bits;  conditional E-value: 0.0017
                 GCSTTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+ n Cs++GtC    +g  +C+C +G+tG 
  EFC37621.1 640 CP-NDCSGHGTC----DGPNSCTCNSGWTGL 665
                 44.67*******....67799********95 PP

  == domain 13  score: 6.7 bits;  conditional E-value: 0.0015
                 T-EEEEETTTEEEEEECTTEESTT CS
         EGF   9 gGtCvdtgrggytCiCpeGytGkr 32 
                 +G+C ++      C C +G+tG++
  EFC37621.1 686 NGKCTSPD----VCSCNSGWTGNN 705
                 68896666....9*********86 PP

  == domain 14  score: -3.9 bits;  conditional E-value: 3
                 GCSTTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGytG 30 
                 C+ n C  +G C  +     tC+C  G+ G
  EFC37621.1 711 CT-NGCGSNGVCTAPN----TCTCNDGWMG 735
                 44.5677777776665....******9966 PP

  == domain 15  score: 16.9 bits;  conditional E-value: 9.9e-07
                 GCSTTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+ n Cs +G+Cv++     +C C+ G+tG+
  EFC37621.1 743 CP-NQCSAHGKCVSPA----ICSCTAGWTGN 768
                 65.88*******9999....**********8 PP

  == domain 16  score: -0.2 bits;  conditional E-value: 0.22
                 STTT-EEEEET.TTEEEEEECTTEE CS
         EGF   6 CsngGtCvdtg.rggytCiCpeGyt 29 
                 C  g  C++++     tC+C+eG++
  EFC37621.1 775 CTSG--CLQGScTSPNTCTCKEGWK 797
                 4445..5555556666*******96 PP

  == domain 17  score: 4.7 bits;  conditional E-value: 0.0065
                 T-EEEEETTTEEEEEECTTEEST CS
         EGF   9 gGtCvdtgrggytCiCpeGytGk 31 
                 +G+C+++      C C++ +tG+
  EFC37621.1 806 HGKCLSPD----ACNCTSEWTGP 824
                 799*9888....**********7 PP

  == domain 18  score: 5.7 bits;  conditional E-value: 0.0032
                 TTT-EEEEETTTEEEEEECTTEES CS
         EGF   7 sngGtCvdtgrggytCiCpeGytG 30 
                 sn+G Cv +     tC+C+eG+tG
  EFC37621.1 838 SNQGLCVAPN----TCECKEGWTG 857
                 5777788888....*********9 PP

  == domain 19  score: 7.7 bits;  conditional E-value: 0.00072
                 T-EEEEETTTEEEEEECTTEEST CS
         EGF   9 gGtCvdtgrggytCiCpeGytGk 31 
                 +G+Cvd+      C+C++ +tG+
  EFC37621.1 879 HGKCVDLA----VCDCTSEWTGS 897
                 79******....*********97 PP

  == domain 20  score: 8.6 bits;  conditional E-value: 0.0004
                 TTT-EEEEETTTEEEEEECTTEEST CS
         EGF   7 sngGtCvdtgrggytCiCpeGytGk 31 
                 sn+G Cv +     tC+C+eG+tG+
  EFC37621.1 911 SNQGLCVAPN----TCECKEGWTGA 931
                 799*******....**********7 PP

  == domain 21  score: 3.0 bits;  conditional E-value: 0.022
                 T-EEEEETTTEEEEEECTTEEST CS
         EGF   9 gGtCvdtgrggytCiCpeGytGk 31 
                 +G+Cv++      C C++ +tG+
  EFC37621.1 951 NGKCVSPD----ACNCTSEWTGS 969
                 799*****....*********96 PP

  == domain 22  score: 4.7 bits;  conditional E-value: 0.0065
                  T.STTT-EE.EEET....TTEEEEEECTTEESTT CS
         EGF    5 p.CsngGtC.vdtg....rggytCiCpeGytGkr 32  
                  p C+ng  C   +      g  +C+C+eG+tGk+
  EFC37621.1  974 PvCING--CgN-SNqglcVGPNICRCKEGWTGKN 1004
                  667777..742.22255667779*********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1034 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       689  (0.0384294); expected 358.6 (0.02)
Passed bias filter:                      198  (0.0110436); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.84u 0.34s 00:00:01.18 Elapsed: 00:00:00.66
# Mc/sec: 4734.34
//
Query:       EFC37622.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.063   11.9   2.2      0.093   11.4   2.2    1.2  1  Strabismus  Strabismus protein
        0.9    7.7   5.7       0.16   10.2   2.4    1.4  2  DUF2070     Predicted membrane protein (DUF2070)
          1    9.2   9.8       0.73    9.6   6.9    2.0  2  IRK         Inward rectifier potassium channel transmembrane 
        1.6    9.2  16.4         39    4.8  16.4    2.4  1  ZapB        Cell division protein ZapB
        2.6    8.6  14.6        4.5    7.8  14.6    1.3  1  APG6_N      Apg6 coiled-coil region


Domain annotation for each model (and alignments):
>> Strabismus  Strabismus protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   2.2   2.6e-05     0.093      59     144 ..     179     281 ..     160     333 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 2.6e-05
  Strabismus  59 tGtseqsisaedvsklsk.dl.eeslgle.ckrylgtalaavlsllaflsPlafvvlPkl..............ewkeqlekCgaeCeGllislafkll 140
                   t+ + is  + ++ ++ d+  e ++ +     ++++   ++ l  f + l+++++P+               e k++ +kC+ +C+  + slaf ll
  EFC37622.1 179 NSTTTDIISFYSTTNSTSnDStTEPITKRtEVATIESVTGWIMVLDFFRTYLMILIIPSSiiwytyytedyetkELKHKSNKCNFTCQAFICSLAFVLL 277
                 44444444444443332212202223222023345555666667777889999999999779*********9988888899***************998 PP

  Strabismus 141 iLli 144
                 +  +
  EFC37622.1 278 LGCL 281
                 7433 PP

>> DUF2070  Predicted membrane protein (DUF2070)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   0.1       1.1   3.8e+03      40      60 ..     131     151 ..     122     167 .. 0.49
   2 ?   10.2   2.4   4.5e-05      0.16      73     159 ..     222     323 ..     200     333 .. 0.75

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 1.1
     DUF2070  40 gillfglpalvaflltlpvlr 60 
                 ++l f+  ++ a+ ltl +++
  EFC37622.1 131 SLLQFITLMICAATLTLYWIN 151
                 333333334444444433333 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 4.5e-05
     DUF2070  73 flalltelivviisllaillsall...............qalvllalvlslalvfalrllvlvavsdesllkavlpaliqpllailllvlyfspesfll 156
                 +l ++ + ++++i+  +i+ +++                 +++ +a+++sla+v+ l  l+++ +++++l++    +++ +++++ + +++ s  s++l
  EFC37622.1 222 VLDFFRTYLMILIIPSSIIWYTYYtedyetkelkhksnkCNFTCQAFICSLAFVLLLGCLIFFGYAENTLSWQCPTVSNPLVIYLSMGMFLCSLLSIIL 320
                 55555555555544444444433356666667777777778999******************************9999888888888888866666666 PP

     DUF2070 157 lll 159
                 +++
  EFC37622.1 321 YFI 323
                 555 PP

>> IRK  Inward rectifier potassium channel transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.27   9.8e+02      24      59 ..     113     150 ..     106     180 .. 0.71
   2 ?    9.6   6.9    0.0002      0.73      37     132 ..     221     317 ..     209     325 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.27
         IRK  24 Dlfttlvdlkwryllllfvlsfvlswllfa..llwyli 59 
                  + tt v  + r  l +f+l  +++ ++ a  l+ y+i
  EFC37622.1 113 QVTTTNVKNENRSRLWCFSLLQFITLMICAatLTLYWI 150
                 56788888888888888876655555555412234444 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0002
         IRK  37 llllfvlsfvlswllfallwylialahgDleeeekeeekepCvanvksftsallfsl..EtqttigyGsrvvteeCpeailllviqsivgllidavlv 132
                 ++l f+ ++++  ++ + + ++  +   D e++e ++++++C  + + f+  l f l        gy +++++ +Cp+    lvi + +g+++ ++l 
  EFC37622.1 221 MVLDFFRTYLMILIIPSSIIWYT-YYTEDYETKELKHKSNKCNFTCQAFICSLAFVLllGCLIFFGYAENTLSWQCPTVSNPLVIYLSMGMFLCSLLS 317
                 45568999999998877666654.566899999****************9877776611555666777889999****99999999999988866554 PP

>> ZapB  Cell division protein ZapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8  16.4     0.011        39      12      64 ..      31      90 ..      23     126 .. 0.75

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.011
        ZapB 12 kiqkaidtitlLqmeieeLkeeneelkeenrele.......eeneqlkeereawqerlkk 64
                + +++  +i++L+ e++ L e++ el++ ++ l+       +en++l++e  ++++ l k
  EFC37622.1 31 RMEELRKQIEELKIENSLLYEQSIELANTQETLKntndeykRENSKLEQENIEQKSDLAK 90
                555555566666666666666664444444444466666669999999999888887765 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8  14.6    0.0013       4.5      51     122 ..      14      91 ..       3      94 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0013
      APG6_N  51 eleee......leklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreynelqlelleleeeldsl 122
                 e++++      +++ e   eel ++++el+ e++ l ++  +l+++ e l++ ++++ re ++l+ e +e + +l+++
  EFC37622.1  14 EAQKKngnflqIQRNELRMEELRKQIEELKIENSLLYEQSIELANTQETLKNTNDEYKRENSKLEQENIEQKSDLAKI 91 
                 333333455557777888888899999999999999999999999999999999999999998888888888777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1886  (0.105193); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2115.55
//
Query:       EFC37623.1  [L=499]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (499 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       498  (0.0277762); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.22s 00:00:00.65 Elapsed: 00:00:00.39
# Mc/sec: 3851.72
//
Query:       EFC37624.1  [L=759]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.016   15.4   2.1       0.35   11.1   0.5    2.5  2  DUF4879   Domain of unknown function (DUF4879)
      0.019   15.0   2.9      0.047   13.7   2.9    1.6  1  TM_helix  Conserved TM helix


Domain annotation for each model (and alignments):
>> DUF4879  Domain of unknown function (DUF4879)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.5   3.9e-05      0.35      28      70 ..     112     154 ..     102     166 .. 0.87
   2 ?    3.0   0.0     0.013   1.1e+02      44      84 ..     674     712 ..     656     743 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 3.9e-05
                 T--B-SS---SSEEEEEEEEESBTTTTS-GGGTSS-----B-- CS
     DUF4879  28 gqtktqcdhgGsklrvavleiGYGkngvallnggqaknyksda 70 
                  +t ++  h G+++r +vl +GYG +   +++ +   nyk+++
  EFC37624.1 112 VNTLSEIAHVGKIMRQQVLSYGYGISDYSKVEVSMYGNYKTSQ 154
                 5789999*******************99999999999998875 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.013
                 EEEEESBTTTTS-GGGTSS-----B--B--.........SS CS
     DUF4879  44 avleiGYGkngvallnggqaknyksdavcgsgsytvscsag 84 
                 +   +G Gkn+ +++  ++++  +++ vc ++ +   c+++
  EFC37624.1 674 YFTIMGSGKNNLENMLHSSSS-LDVQIVCSDNVK-LVCENS 712
                 5566999**999999995555.99**99995544.446555 PP

>> TM_helix  Conserved TM helix
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   2.9   5.2e-06     0.047       8      40 ..     403     435 ..     399     444 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 5.2e-06
                 HHHHTTHSHHHHHHHHHHHHHHHHHHHHHHHHH CS
    TM_helix   8 nellsflPnLvgAilILlvGwiiAkfvsrlvtk 40 
                 +++++ ++  +g ilI  +G i+A+fvs  + k
  EFC37624.1 403 STIIAVIIAMIGSILIICIGIIVATFVSLKIVK 435
                 689999*********************976655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (759 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1124  (0.0626917); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.26s 00:00:00.98 Elapsed: 00:00:00.46
# Mc/sec: 4969.41
//
Query:       EFC37625.1  [L=370]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.8e-12   44.9   1.0    9.7e-12   44.6   1.0    1.1  1  PhoD       PhoD-like phosphatase
  ------ inclusion threshold ------
       0.09   12.7   0.1       0.19   11.6   0.1    1.5  1  Prefoldin  Prefoldin subunit


Domain annotation for each model (and alignments):
>> PhoD  PhoD-like phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.6   1.0   1.1e-15   9.7e-12       4     133 ..     200     332 ..     197     370 .] 0.70

  Alignments for each domain:
  == domain 1  score: 44.6 bits;  conditional E-value: 1.1e-15
        PhoD   4 vSCqnye..agyfnayrelaee.edlDlvlhlGDyiYey.gpgeyase.aaelgrevepp.keivtladYReryaqyktdadlqaahaaapfivvwDDH 96 
                 vSC+  e  +    +++++ e+ ++ D++lh+GD iY++ g++ ++ + +    r+++ + +e +  +++R+ ++ +      +++ ++++  +++DDH
  EFC37625.1 200 VSCNFIEkrEPEKDTWERMNEQiDNTDVLLHIGDQIYADyGHNAFDEAvKICNSRNKVSEeEEELIKEEFRKYHRFNWNHIATRNILSQVSNQMILDDH 298
                 6775544234567899*****966**************94455555544444444444445888999******************************** PP

        PhoD  97 EvaNnswsggaenhqeetegdf.ekrkaaAlqAyfEwm 133
                 E++++ w ++ e ++    g++     + A+  y E++
  EFC37625.1 299 EIRDD-WGSNLEDQT---PGSIpYYIGSLAREVYWEYQ 332
                 *****.*98555554...55552345667777777775 PP

>> Prefoldin  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   2.2e-05      0.19      56     102 ..     222     271 ..     218     275 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.2e-05
                 -STTEEEEEEETTEEEEE...EHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  56 kdtdkvlvdlGagyyvek...sleeAiellkkkleelekqlekleeelek 102
                 +d+ +vl+++G  +y+++    ++eA+++++ + +  e+  e ++ee +k
  EFC37625.1 222 IDNTDVLLHIGDQIYADYghnAFDEAVKICNSRNKVSEEEEELIKEEFRK 271
                 68899************955569************999999988888766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       713  (0.039768); expected 358.6 (0.02)
Passed bias filter:                      426  (0.0237604); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 2117.08
//
Query:       EFC37626.1  [L=336]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.8e-28   97.8   0.9    7.7e-28   97.1   0.9    1.3  1  Ras          Ras family
    4.2e-13   49.6   0.0    7.3e-13   48.8   0.0    1.4  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    5.1e-08   32.6   0.3      1e-07   31.6   0.2    1.4  2  Arf          ADP-ribosylation factor family
    1.5e-07   31.2   0.1    5.2e-07   29.4   0.2    1.7  2  GTP_EFTU     Elongation factor Tu GTP binding domain
    0.00022   21.2   1.3        1.5    8.7   0.4    3.1  3  RsgA_GTPase  RsgA GTPase
     0.0062   16.6   0.2      0.018   15.1   0.2    1.8  1  MMR_HSR1     50S ribosome-binding GTPase
  ------ inclusion threshold ------
      0.018   14.0   0.7          1    8.3   0.0    2.2  2  MeaB         Methylmalonyl Co-A mutase-associated GTPase MeaB
      0.032   14.5   0.3       0.27   11.5   0.3    2.2  1  AAA_22       AAA domain
       0.14   12.5   0.0        0.3   11.5   0.0    1.6  1  AAA_16       AAA ATPase domain
       0.18   11.6   1.2       0.57    9.9   0.2    2.1  2  ATP_bind_1   Conserved hypothetical ATP binding protein
        1.3    9.0   5.3         35    4.3   0.4    3.0  3  ResIII       Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.1   0.9   4.7e-31   7.7e-28       1     158 [.     133     300 ..     133     303 .. 0.87

  Alignments for each domain:
  == domain 1  score: 97.1 bits;  conditional E-value: 4.7e-31
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 ++v++G+++vGK++l++ +v + F + y++Ti +d+y+k  +vd++ + lei+DTAG ++f++++++y + +++++ v ++++ e+ + +++ ve i +
  EFC37626.1 133 RMVVIGEEGVGKSALTIFYVVNIFVDLYDPTI-EDSYRKVAQVDNRVALLEIMDTAGNQDFEAFKQNYTTFGNCFVAVCSVDNLETVKALRHRVEYIIK 230
                 58******************************.**********************************************************99999999 PP

                 HST...TTSEEEEEEETTTGGG..........G-SS-HHHHHHHH...HHHTSEEEEEBTTTTCTHHHHHHHHHH CS
         Ras 100 vae...envpivLvGnKvDlee..........kravsteegeela...kelglkfletSAktnenveeafeellr 158
                 ++e   +++piv v nKvDl e          k++++      +    + l++  +e SAk+ en++ +fee +r
  EFC37626.1 231 IKErpvNDTPIVFVINKVDLLEtnrdetlnefKKEINL-----IIkefSLLNTSIVESSAKKGENINLIFEEGVR 300
                 99988999***********9986665443333333332.....2322244567889**************98765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.8   0.0   4.5e-16   7.3e-13       1     120 []     133     250 ..     133     250 .. 0.78

  Alignments for each domain:
  == domain 1  score: 48.8 bits;  conditional E-value: 4.5e-16
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 ++v++G++gvGK+ l   +v + f + +++ti  ++ +  v    +v+n    +   l+i DtaG+++f++ ++ y +  +++++v+     ++ + l+
  EFC37626.1 133 RMVVIGEEGVGKSALTIFYVVNIFVDLYDPTIEDSYRK--VA---QVDN----RVALLEIMDTAGNQDFEAFKQNYTTFGNCFVAVCSvdnLETVKALR 222
                 589******************************99854..33...3433....34689************************99998643533334333 PP

                 ...HHHHHHHHH.CSSS-EEEEEE-TTT CS
         Roc  97 ...eWlkelkkv.agkspvilvgnkiDl 120
                    e++ ++k++ ++++p+++v+nk+Dl
  EFC37626.1 223 hrvEYIIKIKERpVNDTPIVFVINKVDL 250
                 22256677776636778*********95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       3.4   5.6e+03     111     135 ..      37      61 ..      32      78 .. 0.66
   2 !   31.6   0.2   6.1e-11     1e-07      10     164 ..     127     291 ..     118     298 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.4
                 GCCTTSEEEEEEE-TTSTTSS-HHH CS
         Arf 111 eelkevallvlaNKqDlpealseee 135
                 ++  +  ++ +aN q l++ +s+++
  EFC37626.1  37 KHETHSDIVFIANFQSLSKKISHSK 61 
                 5555566667777777777766543 PP

  == domain 2  score: 31.6 bits;  conditional E-value: 6.1e-11
                 T.TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEEEEE...TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHH CS
         Arf  10 lkkkelrilllGLDnaGKtTilkklkleelvt.tvPTigfnveelei...knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeL 104
                 ++  e+r++++G ++ GK+ +   +  + +v+   PTi    ++++    +   +++ D  G++    + +nY++  +  + v  + + e ++  ++ +
  EFC37626.1 127 GAAEEYRMVVIGEEGVGKSALTIFYVVNIFVDlYDPTIEDSYRKVAQvdnRVALLEIMDTAGNQDFEAFKQNYTTFGNCFVAVCSVDNLETVKALRHRV 225
                 45789**************9999999998888578***987766655332666789*************************999999999999999999 PP

                 HHHCTSGC..CTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSS....SSSSEEEEEEBTTTTBTH CS
         Arf 105 kalleeee..lkevallvlaNKqDlpealseeelrellgleelk....gkrkleiqkcsavkgegl 164
                 + +++ +e  +++ +++ + NK Dl e+  +e l+e  +  +l     +  + +i+++sa kge++
  EFC37626.1 226 EYIIKIKErpVNDTPIVFVINKVDLLETNRDETLNEFKKEINLIikefSLLNTSIVESSAKKGENI 291
                 999887763367*******************99999999888652344455666777777777665 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       1.2   1.9e+03       5      20 ..     133     148 ..     130     150 .. 0.90
   2 !   29.4   0.2   3.2e-10   5.2e-07      62     187 ..     170     297 ..     161     325 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.2
                 EEEEEESTTSSHHHHH CS
    GTP_EFTU   5 nigiighvDhGKtTLt 20 
                  +++ig    GK+ Lt
  EFC37626.1 133 RMVVIGEEGVGKSALT 148
                 6899*********997 PP

  == domain 2  score: 29.4 bits;  conditional E-value: 3.2e-10
                 EEET.TCSSEEEEEEEESSSGGGH..HHHHHHHHT-SEEEEEEETTTBSTHHHHHHHHHHH..HTTTE...EEEEEESCGSTHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  62 slek.etkkylinliDtPGHvdFs..kevirglrvlDgavlvvdaveGvepqteevlrlal..kegvp...iivfiNKmDrlkaelkeiveevkqklsr 152
                 ++ + + +  l+ ++Dt G +dF   k+ +++   + +av  vd  e v++   +v ++++  ++ v+   i+++iNK+D l+++ +e+ +e k+++  
  EFC37626.1 170 KVAQvDNRVALLEIMDTAGNQDFEafKQNYTTFGNCFVAVCSVDNLETVKALRHRVEYIIKikERPVNdtpIVFVINKVDLLETNRDETLNEFKKEI-- 266
                 4443357778999**********7224555556666666666666677666555544444300443446659999*******999999999999998.. PP

                 HHHHHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHH CS
    GTP_EFTU 153 keeklekygekgekevpvvfgSalkgegvktllea 187
                  +  ++++      ++++v  Sa+kge+++ ++e 
  EFC37626.1 267 -NLIIKEFSLL---NTSIVESSAKKGENINLIFEE 297
                 .3444444433...579***********9966654 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0012         2      96     116 ..     128     148 ..      86     156 .. 0.60
   2 ?    2.0   0.0       0.1   1.7e+02      52      97 ..     180     225 ..     169     231 .. 0.80
   3 !    8.7   0.4   0.00093       1.5      45      91 ..     237     292 ..     206     298 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0012
                  HCTTSEEEEECSTTSSHHHHH CS
  RsgA_GTPase  96 llkdktsvlvGqSGvGKStLi 116
                  + ++  +v++G+ GvGKS+L 
   EFC37626.1 128 AAEEYRMVVIGEEGVGKSALT 148
                  334467899*********995 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.1
                  EEE-GGG--HHHHHHHHHHHHHHTT.SEEEE--TTTHTTHHHHHHHC CS
  RsgA_GTPase  52 vlnKiDlleeeeeleelkeelealg.yevllvsaktkegleelkell 97 
                  +l  +D + +++ +e++k++++++g + v ++s+++ e++++l++++
   EFC37626.1 180 LLEIMDTAGNQD-FEAFKQNYTTFGnCFVAVCSVDNLETVKALRHRV 225
                  456678888888.9*********984667789999999999998776 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00093
                  TT-EEEEEEE-GGG--HHH.........HHHHHHHHHHHTTSEEEE--TTTHTTHH CS
  RsgA_GTPase  45 kgiepvivlnKiDlleeee.........eleelkeelealgyevllvsaktkegle 91 
                  ++ ++v v+nK+Dlle+++         e++ + +e++ l+++++  sak++e+++
   EFC37626.1 237 NDTPIVFVINKVDLLETNRdetlnefkkEINLIIKEFSLLNTSIVESSAKKGENIN 292
                  4557899********99887777777766777777777777777777777777766 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.2   1.1e-05     0.018       2     114 .]     134     247 ..     133     247 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.1e-05
                 EEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEE.ETT..EEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETTTTCSHHHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvk.lkg..keielvDtpGliegaseekglgkaflaleeadlillvvdaseeklkpldeel 97 
                 ++++G   vGKS L    +  + i  d    T++  +++v+ +++    +e++Dt+G  +   + + +++++    ++ +++  vd + e++k+l++++
  EFC37626.1 134 MVVIGEEGVGKSALTIFYV--VNIFVDLYDPTIEDSYRKVAqVDNrvALLEIMDTAG-NQ---DFEAFKQNYTTFGNCFVAVCSVD-NLETVKALRHRV 225
                 789**********965554..45777777788888888877422223569*******.43...45589999999999999999999.656566666555 PP

                 HHHHHH.....TTSEEEEEEES CS
    MMR_HSR1  98 eellee.....akkplilvlnk 114
                 e +++      ++ p+++v+nk
  EFC37626.1 226 EYIIKIkerpvNDTPIVFVINK 247
                 4444333358888899999998 PP

>> MeaB  Methylmalonyl Co-A mutase-associated GTPase MeaB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.2     0.016        25     121     156 ..     131     166 ..     125     190 .. 0.81
   2 ?    8.3   0.0   0.00062         1     171     224 ..     242     297 ..     229     310 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.016
                 T-SEEEEEEESSTTHHHHHHTT-SEEEEEEESSTTT CS
        MeaB 121 GfDvvlietvGvGqsevdvaevvdtfvvlllpeaGD 156
                  + +v+i   GvG+s   +  vv++fv l  p   D
  EFC37626.1 131 EYRMVVIGEEGVGKSALTIFYVVNIFVDLYDPTIED 166
                 6889999999****************9987666555 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00062
                 EEEEE---..HHHHHHHHHHHHHHHHHCSTTBTTB--EEEEEBCCCTBSHHHHHHH CS
        MeaB 171 iivvnkaD..kkeaekaarelraaleleeekekeWrpkvlktsavegeGidelvda 224
                 ++v+nk D  +++ +++ +e+++ ++l  ++ +  ++ +++ sa++ge i+ ++++
  EFC37626.1 242 VFVINKVDllETNRDETLNEFKKEINLIIKEFSLLNTSIVESSAKKGENINLIFEE 297
                 78******555555667789999999999999******************998875 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.3   0.00017      0.27       8     114 ..     134     264 ..     129     281 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00017
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaee..............erpevvfvtlpsstsskdllrellralglelka............erlsseelle 80 
                 +vv+Ge G+GK+ l   ++ +   +                    + +v++ ++    + +d+ +++ ++++    +            +  + ++l++
  EFC37626.1 134 MVVIGEEGVGKSALTIFYVVNIFVD----LydptiedsyrkvaqVDNRVALLEIMDTAGNQDF-EAFKQNYT----TfgncfvavcsvdNLETVKALRH 223
                 79**********9877766553211....1112234555555543333333333333333333.33333333....03344667777788888888888 PP

      AAA_22  81 aleqalrarav.....ielliiDEaqhlr..seealeeLrs 114
                 ++e  ++ + +     + +++i  ++ l   ++e l+e+++
  EFC37626.1 224 RVEYIIKIKERpvndtPIVFVINKVDLLEtnRDETLNEFKK 264
                 88888888888888888888888888886544888888765 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00018       0.3      14     149 ..     119     253 ..     110     275 .. 0.57

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00018
      AAA_16  14 salervrsgrp..elvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawrekleeala.... 106
                  +l++++ g      ++++Ge GvGKs+l       +  d    l+  + +     +y  +aq+  r  ll+ ++++  ++++ea+++   ++++    
  EFC37626.1 119 GTLKNAKNGAAeeYRMVVIGEEGVGKSALTIFYVVNIFVD----LYDPTIED----SYRKVAQVDNRVALLEIMDTA-GNQDFEAFKQ-NYTTFGncfv 207
                 55666666666654567***********982222222222....44444444....555566666555555555555.3324444444.2333336777 PP

      AAA_16 107 ...avpelagaea.srllellkrllallsrderplvlvlDdlqwade 149
                    +v++l+  +a ++  e + ++ ++  + + p+v+v+  ++ +++
  EFC37626.1 208 avcSVDNLETVKAlRHRVEYIIKIKERPVN-DTPIVFVINKVDLLET 253
                 666666666665554444444555555555.6667777776666655 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.65   1.1e+03       1      13 [.     136     148 ..     136     163 .. 0.89
   2 ?    9.9   0.2   0.00035      0.57     155     220 ..     237     307 ..     192     312 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.65
  ATP_bind_1   1 vvGpaGsGKttfv 13 
                 v+G  G+GK+ ++
  EFC37626.1 136 VIGEEGVGKSALT 148
                 89********875 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00035
  ATP_bind_1 155 lelPhvvvlnkfDllkek.....lekeleffedvealslllekeeekykklaeaiaelleefalvlrflpl 220
                  ++P v v+nk+Dll+++     +e++ e    ++++sll+++  e  +k  e+i  ++ee  ++ rf+ +
  EFC37626.1 237 NDTPIVFVINKVDLLETNrdetlNEFKKEINLIIKEFSLLNTSIVESSAKKGENINLIFEEGVRMERFYRV 307
                 679************98865555555555555556666666666677788888888888877766666655 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.1      0.06        98      95     123 ..      34      62 ..       5      82 .. 0.65
   2 ?    4.3   0.4     0.022        35      15      98 ..     120     233 ..     105     270 .. 0.62
   3 ?    3.9   0.6     0.029        48      56     109 ..     240     296 ..     225     308 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.06
                 --.......-SEEEEEHHHHHHTH..... CS
      ResIII  95 kakekdstnkkilvttiqsldadseeeee 123
                  ++++++++  +++++ qsl++++++ +e
  EFC37626.1  34 FRSKHETHSDIVFIANFQSLSKKISHSKE 62 
                 23455556666667788888888744333 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.022
                 HT........TTSEEEEEESTTSTHHHHHHHHHHHH-S............-EEEEESSHHHHHHHH....HHGGGGTGG..........GEEEESSS-B CS
      ResIII  15 lleklks..krdkrglikmaTGtGKTlvaaklierllkkgkee.......kflflvprkslleqtl....eefkkflseayke......igkkvsgdkk 94 
                 +l++ k+   ++ r+++  + G+GK+ + +  + +++   +         k+  + +r +lle +     ++f+ f+++++++      +    s d+ 
  EFC37626.1 120 TLKNAKNgaAEEYRMVVIGEEGVGKSALTIFYVVNIFVDLYDPtiedsyrKVAQVDNRVALLEIMDtagnQDFEAFKQNYTTFgncfvaV---CSVDNL 215
                 444444454566688899999999999888888888877776678888888888888999988888888889999999988886663331...333333 PP

                 --................ CS
      ResIII  95 ka..............ke 98 
                 +               ke
  EFC37626.1 216 ETvkalrhrveyiikiKE 233
                 333333344445555433 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.029
                 -EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--..........-SEEEE CS
      ResIII  56 kflflvprkslleqtleefkkflseaykeigkkvsgdkkka...kekdstnkkilvt 109
                  ++f++++ +lle  ++e  + ++++ + i k++s  + ++   ++k+ +n++++++
  EFC37626.1 240 PIVFVINKVDLLETNRDETLNEFKKEINLIIKEFSLLNTSIvesSAKKGENINLIFE 296
                 79**************99888888887666676666666666555555566666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       899  (0.0501422); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 1897.77
//
Query:       EFC37627.1  [L=150]
Description: cofilin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.5e-23   82.2   0.5    2.8e-23   82.0   0.5    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
  ------ inclusion threshold ------
      0.012   15.6   0.6      0.016   15.2   0.6    1.2  1  SelP_C       Selenoprotein P, C terminal region


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.0   0.5   3.1e-27   2.8e-23       2     121 .]      12     144 ..      11     144 .. 0.94

  Alignments for each domain:
  == domain 1  score: 82.0 bits;  conditional E-value: 3.1e-27
                  HHHHHHHCTTT.....SSEEEEEEECTTTEEEEEESS-...HHHHHHHHHHTTT-EEEEEEEEEECCS........ECCEEEEEEEEE--TTS-HHHH CS
  Cofilin_ADF   2 keafkelksgk....ktkyilfkidddkeeivveeege...tyeelreelpeseprYavydveyehdd........eskrsklvfIswvPdsapikqk 84 
                  +++++e+++gk    ++k++++k+++   +i++++e +   +++el+++lp ++ r+++y++++e ++        e++r+k++f++w+P+++++k+k
   EFC37627.1  12 LKTYEEMRMGKgsnkDKKFLVLKMQES--SIQIDQELSqlsSLDELTANLPPKNSRFICYHLSFEMPSqnetcqirEGTRTKMMFLTWCPNETNVKEK 107
                  5789********99999*******976..69999966677899***********************999999****9**************99***** PP

                  HHHHHHHHHHHHHCTTSEEEEEE-CGGCCSHHHHHHH CS
  Cofilin_ADF  85 mlyasskdalkkelkgisveieatdldelteeelkek 121
                    +a++ +++k++l+g+s +i++++++e++e ++ ek
   EFC37627.1 108 FQVAATVKTVKQKLNGLSATIHCSTKSEIDERSMIEK 144
                  *******************************999886 PP

>> SelP_C  Selenoprotein P, C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   0.6   1.8e-06     0.016      32     124 ..      40     135 ..      13     145 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.8e-06
      SelP_C  32 rcinqllcklskdseaa....lssccchcrhlifektgsaitcqcaenlpslc.scqgllaeekviescqcrlppaacqisqqlnpteasakcscknk 124
                   i+q l +ls   e++    ++     c hl fe      tcq +e   +          e +v e  q+     ++  +q+ln + a+ +cs k +
  EFC37627.1  40 IQIDQELSQLSSLDELTanlpPKNSRFICYHLSFEMPSQNETCQIREGTRTKMmFLTWCPNETNVKEKFQVAATVKTV--KQKLNGLSATIHCSTKSE 135
                 4577778888765554312226788889******************987654404455567899***99987665554..6************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       838  (0.0467399); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.42
# Mc/sec: 1076.27
//
Query:       EFC37628.1  [L=98]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.7e-35  119.9  13.9    4.7e-35  119.9  13.9    1.6  2  Ribosomal_L44  Ribosomal protein L44


Domain annotation for each model (and alignments):
>> Ribosomal_L44  Ribosomal protein L44
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.4      0.28     5e+03      52      59 ..       8      15 ..       6      16 .. 0.82
   2 !  119.9  13.9   2.6e-39   4.7e-35       1      76 []      17      92 ..      17      92 .. 0.99

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.28
                   EEEEETTT CS
  Ribosomal_L44 52 lrleCteC 59
                   l+  C++C
     EFC37628.1  8 LKAYCQKC 15
                   78899999 PP

  == domain 2  score: 119.9 bits;  conditional E-value: 2.6e-39
                   EEEEEEEEE-------SSSHHHHHHHH.H-SSSGGGGS----.--SSBB--EEEEETTT--EEE----BBS--EEE CS
  Ribosomal_L44  1 kHtehkveqykkgkdselaqgkRrydrkqsgygGqtkpvfkkkaKttKKivlrleCteCkkkrlkalkRakkfelv 76
                   +H+ehkv+qyk+gk+s  aqgkRrydrkq+gygGqtkp+f+kkaKttKKivlrl+C+eCk+  ++ +kR+k+fel+
     EFC37628.1 17 THKEHKVTQYKAGKASLWAQGKRRYDRKQKGYGGQTKPIFHKKAKTTKKIVLRLQCKECKRINQRGIKRCKHFELG 92
                   6*************************************************************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (98 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1139  (0.0635284); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.25s 00:00:00.67 Elapsed: 00:00:00.42
# Mc/sec: 697.51
//
Query:       EFC37629.1  [L=634]
Description: UDP-glucose:solanidine glucosyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-16   60.7   0.2    2.2e-15   56.5   0.0    2.3  2  UDPGT            UDP-glucoronosyl and UDP-glucosyl transferas
    0.00011   22.2   0.0     0.0004   20.4   0.0    2.0  2  Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal dom
  ------ inclusion threshold ------
      0.059   13.5   1.5       0.18   11.9   0.1    2.5  2  DUF5392          Family of unknown function (DUF5392)


Domain annotation for each model (and alignments):
>> UDPGT  UDP-glucoronosyl and UDP-glucosyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.5   0.0   3.6e-19   2.2e-15     277     414 ..     386     530 ..     363     542 .. 0.78
   2 ?    1.7   0.1     0.014        86     447     486 ..     585     623 ..     582     634 .] 0.81

  Alignments for each domain:
  == domain 1  score: 56.5 bits;  conditional E-value: 3.6e-19
       UDPGT 277 vvvfSlGsmvseipeekanaiAsaLakipq..kvlWrfdgkkPstLaknt....llvkWlPqndlLgHPktkAFvtHaGangvyEaisnGvPmvglPlF 369
                 +v++++G+   ei+ e++ +i + + k+ +  +v+  ++g+   +L +      l   W+ q  +L H  t  FvtHaGa++++Ea+ n vP+ + P+F
  EFC37629.1 386 IVYVAFGTKL-EISHEHITTILNFIVKSDEniRVICVHEGHAKLNLSESVsskiLFQTWVNQELILSHSATSVFVTHAGAHSLFEAVDNQVPILTFPIF 483
                 7788888765.56666677777777666542257778888777777666556646678***************************************** PP

       UDPGT 370 gdqrdNikrmeakgaavtlnvk..emtsedllnAlkevindksyken 414
                 +dq  N  r e  g +  + +   +   + + + +k+v++d++  + 
  EFC37629.1 484 ADQFSNSVRSEDLGFGFDISEDiyNRDEKSFVKSMKTVLRDRMEIKK 530
                 ************999887765500556678999******99864433 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.014
       UDPGT 447 khlRaaahdLtWyqyhsLDvigfllavvvtvafiivkecl 486
                 +hlR  +  L+Wy    +  i f  ++ +   f+++++c 
  EFC37629.1 585 EHLRDVSTKLSWYIQLNIPLI-FVSSIALSLLFLTFRCCF 623
                 6***********988777776.999999*********985 PP

>> Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0      0.95   5.7e+03      91     104 ..      48      61 ..      29      72 .. 0.65
   2 !   20.4   0.0   6.7e-08    0.0004      71     155 ..     453     535 ..     402     550 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.95
                      TT--EEEE--TT.. CS
  Glyco_tran_28_C  91 lgkplIlvplpeaa 104
                        k ++++p p+++
       EFC37629.1  48 TRKQFVFIPTPDSS 61 
                      45667777777755 PP

  == domain 2  score: 20.4 bits;  conditional E-value: 6.7e-08
                      HHH-EEEECS-CHHHHHHHHTT--EEEE--TT....S-HHHHHHHHHHHHHHSSEEEE-S..TTCHHHHHHHHCCS---S---SSCH CS
  Glyco_tran_28_C  71 kaadLvIsRAGagtiaEllalgkplIlvplpeaaenhqdnNakelekagaalvleqkelt..pekLeeallelaaeklrlaekskas 155
                      +a ++ +++AGa +++E++ +++p +++p       +q  N +  e+ g +  + ++  +  +++ ++  ++++ ++++ ++++++ 
       EFC37629.1 453 SATSVFVTHAGAHSLFEAVDNQVPILTFPIFA----DQFSNSVRSEDLGFGFDISEDIYNrdEKSFVKSMKTVLRDRMEIKKRMREI 535
                      45569*************************99....*************99999998776668888888888888888888777775 PP

>> DUF5392  Family of unknown function (DUF5392)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.2      0.44   2.6e+03      34      55 ..      10      31 ..       7      38 .. 0.81
   2 ?   11.9   0.1   3.1e-05      0.18      12      52 ..     579     619 ..     573     628 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.44
     DUF5392 34 slPLllvslinlillllkaele 55
                 lPLl++ ++ l+l++++ +++
  EFC37629.1 10 YLPLLALLAFSLVLIFVHIHAK 31
                5899999999999999888765 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 3.1e-05
     DUF5392  12 EldklqeviaPllkKsskysfislPLllvslinlillllka 52 
                  +d+l e+++ +  K s y  + +PL++vs i l+ll+l++
  EFC37629.1 579 AFDHLDEHLRDVSTKLSWYIQLNIPLIFVSSIALSLLFLTF 619
                 58999******************************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (634 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       936  (0.0522059); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.35s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 3648.75
//
Query:       EFC37630.1  [L=1949]
Description: ras GTPase domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.8e-35  119.9   0.0      2e-34  118.6   0.0    1.8  1  bMG10     Bacterial Alpha-2-macroglobulin MG10 domain
      3e-17   63.3   1.0    5.7e-16   59.1   0.0    3.4  3  A2M_BRD   Alpha-2-macroglobulin bait region domain
    4.4e-16   58.5   0.0    5.3e-15   55.0   0.0    2.8  2  A2M       Alpha-2-macroglobulin family
    4.1e-15   56.0   0.0      7e-14   52.1   0.0    3.2  4  MG2       MG2 domain
    0.00021   21.9   0.1    0.00021   21.9   0.1    5.3  6  Big_5     Bacterial Ig-like domain
    0.00043   20.5   0.4      0.049   13.9   0.0    3.6  3  DUF11     Domain of unknown function DUF11
     0.0086   16.1  13.6      0.092   12.8   0.2    5.8  6  Big_1     Bacterial Ig-like domain (group 1)
  ------ inclusion threshold ------
       0.06   13.5   2.8       0.55   10.4   0.1    3.9  3  MG4       Macroglobulin domain MG4


Domain annotation for each model (and alignments):
>> bMG10  Bacterial Alpha-2-macroglobulin MG10 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.6   0.0   8.8e-38     2e-34       1     130 []    1791    1935 ..    1791    1935 .. 0.97

  Alignments for each domain:
  == domain 1  score: 118.6 bits;  conditional E-value: 8.8e-38
       bMG10    1 GlsveReyeklegkevsksda.....klkvGdkvrvrltvttprdleyvaledplPAGlepvnpslgtesesaeeye..........wleeltefsy 82  
                  G++v+R+ye++ ++ +   d+     ++k+G+++rv+lt+t  +++++val+d+lPAGlep+np+l+ + e  + +           w+ + +++++
  EFC37630.1 1791 GFEVQRTYEHVTDSSHVSFDKekntwRFKAGELIRVKLTMTNTSRRYHVALVDYLPAGLEPINPELKGTPEISSLNGsktnkpnswcWWINPIWYEH 1887
                  9*************9999888999999****************************************99988887778899**************** PP

       bMG10   83 reirddrvvffadylpkgtytfeylvravtpGtfsvppakaeemYaPE 130 
                  ++ird+rv++f++ l +gt++f+y +ra++ G+f +p +kaeemY PE
  EFC37630.1 1888 HNIRDERVEAFTSLLWEGTHQFTYIARATSIGSFVIPSVKAEEMYTPE 1935
                  ***********************************************9 PP

>> A2M_BRD  Alpha-2-macroglobulin bait region domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       4.2   9.3e+03      52      72 ..      33      53 ..      13      70 .. 0.72
   2 ?    0.2   0.0      0.38   8.6e+02       6      64 ..     586     654 ..     582     697 .. 0.68
   3 !   59.1   0.0   2.5e-19   5.7e-16       1     140 []     945    1105 ..     945    1105 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.2
                ...-EEEEEE--TT-----EE CS
                xxxxxxxxxxxxxxxxxxxxx RF
     A2M_BRD 52 idsstsfsfpvtadmaPnarv 72
                 +s +s+++++++ m+P +++
  EFC37630.1 33 DRSVPSITITFSQPMVPVSSI 53
                567889999999999997765 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.38
                 SSSS--TTSEEEEEEE-SS-.........EE-TT-....BSS----.-.-S...S....-EEEEEE--T CS
                 xxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxx RF
     A2M_BRD   6 dkeeykvGetakltvkstfa.........tverdstlylvlsrgni.vssgekveeidsstsfsfpvta 64 
                 d++ yk+Get+ ++   +            ++++s++y +l+ ++    sg+ +  +d++ +++f+v +
  EFC37630.1 586 DRGLYKPGETVSIKGYVRRFnlkgnvfsiDIPTNSSTYTILDARQQrYESGKVQLSSDGTFNIQFKVPD 654
                 677889999988876554334667777777777777788888777767777554455556677776654 PP

  == domain 3  score: 59.1 bits;  conditional E-value: 2.5e-19
                  -EEEESSSS--TTSEEEEEEE-SS-EE-TT-....BSS----.-.-S...S........-EEEEEE--TT-----EEEEEE..E-............ CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............ RF
     A2M_BRD    1 lqispdkeeykvGetakltvkstfatverdstlylvlsrgni.vssgekve....eidsstsfsfpvtadmaPnarvvvyyirrd............ 80  
                  l++ +dk+ey+vGe+ak+ ++s+f+ ++ ++    vl ++   + ++++ +       + t+f++ +t d +Pn++v v +   +            
  EFC37630.1  945 LTLLTDKKEYQVGEKAKILIQSPFD-SKAEG----VLFTQLHgI-HRQY-PiqidADLGYTEFELGITLDHIPNVKVSVEL--SGsesrvdatgtvl 1032
                  67889*******************7.55555....433333323.3333.123332334669***************6666..33357999****** PP

                  .....-CEEEEEEE----.-GGGB-EEEEE.EE...-SSSEEEEEE..E..E.......T-EEEEEEEEHHHHHH CS
                  .....xxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxx..xxxx.......xxxxxxxxxxxxxxxx RF
     A2M_BRD   81 .....gevvadsvqlpvekdfenklsvsle.synetrPgeevtlkv..kasp.......gslvalaaVDksvlll 140 
                       +++ ++s  ++v  + ++ lsv+ + +++  +Pg+e++++v  k +p       g +v+++aVD++vl+l
  EFC37630.1 1033 dlpkqPAFSSGSCDIEVS-KNSRSLSVESKpEREYLTPGSETSISVlvK-DPmtgapqeGCEVCIIAVDEAVLSL 1105
                  ******************.89999**9998647779*********9442.336666688**************87 PP

>> A2M  Alpha-2-macroglobulin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.73   1.6e+03       9      26 ..     640     656 ..     635     679 .. 0.78
   2 !   55.0   0.0   2.4e-18   5.3e-15       2      89 ..    1228    1314 ..    1227    1317 .. 0.96

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.73
                 EC...CEEEEEEEEESSS CS
         A2M   9 vtdasgkaslsftlPDsi 26 
                 ++ ++g+ +++f++PD+ 
  EFC37630.1 640 LS-SDGTFNIQFKVPDNA 656
                 33.689999******974 PP

  == domain 2  score: 55.0 bits;  conditional E-value: 2.4e-18
                  CCEEEEEEC...CEEEEEEEEESSSCEEEEEEEEEETTTEEEEEEEEEEEE--SEEEEEE--SEEETTSEEEEEEEEEE-SSS-EEEE CS
         A2M    2 wlWedvlvtdasgkaslsftlPDsiTtWrvtavalsedkglgvaeplevrvfkpffvdlnlPysvrrgeqveikavvfNyldkeikvr 89  
                  +++++ ++t+a+g +s++f++PD++T++r+tava++ d  +g+ e+ ++ +  p+ ++++lP+++  g++ve ++v+ N+++ +++v+
  EFC37630.1 1228 AIFSPSSKTNAEGFTSVKFKIPDNLTKYRITAVAVKGDWNFGIHES-SMIAQLPLSIRPSLPRFLNFGDRVEFTCVLQNQTQLNLEVN 1314
                  5899******************************************.**********************************9998886 PP

>> MG2  MG2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.1   0.0   3.1e-17     7e-14       2      95 ..     581     680 ..     580     681 .. 0.91
   2 ?   -3.6   0.0       7.3   1.6e+04       4      22 ..     947     965 ..     945     992 .. 0.76
   3 ?   -3.3   0.0       5.6   1.3e+04       8      29 ..    1064    1085 ..    1063    1099 .. 0.74
   4 ?   -2.0   0.0       2.3   5.1e+03      52      70 ..    1233    1251 ..    1214    1271 .. 0.80

  Alignments for each domain:
  == domain 1  score: 52.1 bits;  conditional E-value: 3.1e-17
                 EEEEES-SEE-TT-EEEEEEEEESTTCSB---......EEEEEEEE-TTSSEEEEEEEEE-CTTEEEEEEE--TT--SEEEEEEEEECSTTT-EEEEEE CS
         MG2   2 afvytDRglYrPgetVslkallrdetlqglak......lplkltirdpdgkevkelplatdetggaesefalpeaaklGeysvelsadsaeeslssgsf 94 
                 a+++ DRglY+PgetVs+k+++r  +l+g  +       + + ti d++++++++ +++ +++g+++ +f++p++a lG+ ++ +s+ s +++   ++f
  EFC37630.1 581 AHIFNDRGLYKPGETVSIKGYVRRFNLKGNVFsidiptNSSTYTILDARQQRYESGKVQLSSDGTFNIQFKVPDNANLGSHTIMFSDFSSNHAFKVQEF 679
                 89**********************77777777779999999********************************************88777777777777 PP

                 E CS
         MG2  95 r 95 
                 r
  EFC37630.1 680 R 680
                 5 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 7.3
                 EEES-SEE-TT-EEEEEEE CS
         MG2   4 vytDRglYrPgetVslkal 22 
                 + tD++ Y+ ge+ ++ + 
  EFC37630.1 947 LLTDKKEYQVGEKAKILIQ 965
                 6899999999999887655 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 5.6
                  -SEE-TT-EEEEEEEEESTTCS CS
         MG2    8 RglYrPgetVslkallrdetlq 29  
                  R+ ++Pg + s+++l++d+   
  EFC37630.1 1064 REYLTPGSETSISVLVKDPMTG 1085
                  77789**********9995433 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 2.3
                  EEEE-CTTEEEEEEE--TT CS
         MG2   52 platdetggaesefalpea 70  
                  + +t+++g+ +++f++p++
  EFC37630.1 1233 SSKTNAEGFTSVKFKIPDN 1251
                  4578889999999999987 PP

>> Big_5  Bacterial Ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.1   9.5e-08   0.00021      24     108 .]      38     122 ..      20     122 .. 0.77
   2 ?   -1.1   0.0       1.3     3e+03      25      48 ..     146     169 ..     123     184 .. 0.67
   3 ?   -1.8   0.0       2.3   5.2e+03      66      93 ..     316     342 ..     277     353 .. 0.56
   4 ?   -0.5   0.2      0.91     2e+03      52      96 ..     766     812 ..     751     819 .. 0.63
   5 ?   -1.6   0.0         2   4.4e+03      67      93 ..     895     922 ..     855     931 .. 0.64
   6 ?   -2.2   0.1       3.1   6.9e+03      18      34 ..    1361    1383 ..    1356    1408 .. 0.64

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 9.5e-08
       Big_5  24 eitvtFseavdastvtaatvialsdsettavtgs...ydasg.ktvtitpsaeLaanttYtvtitagikDlagnalaapytniewsFtT 108
                 +it+tFs+++ + ++ ++++ ++ + +  +++ +    ++ g kt++   +  ++ +t+Ytvt+++g k   g  l+++ t   +sF T
  EFC37630.1  38 SITITFSQPMVPVSSIDEVMDTV-PVDVSPLPKKggqFKWLGtKTLVYAAKYRFDMSTKYTVTVKKGTKSEIGGILKEDLT---FSFET 122
                 8*************999988876.4444444444556446666************************88777743666566...99987 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.3
       Big_5  25 itvtFseavdastvtaatvialsd 48 
                   ++F++++d+s v + ++i+ ++
  EFC37630.1 146 YYLEFDQDIDPSEVIKFISINENS 169
                 4689**********9998886544 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 2.3
       Big_5  66 titpsaeLaanttYtvtitagikDlagn 93 
                  i +s++ +  ttY v + ++++D+ g+
  EFC37630.1 316 SISISGKIKGRTTYKVFV-KNLVDVWGQ 342
                 566677788889999988.456787776 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.91
       Big_5  52 tavtgsydasg.ktvtitps.aeLaanttYtvtitagikDlagnala 96 
                 t+++g++d +g ++++i  + ++  +++  t+ ++++++D ++++++
  EFC37630.1 766 TTFEGTTDGDGeHQIAIAFEeSNRVKKAPITISVESTVQDINRQTMT 812
                 34444466666677777777444556667788888888888876443 PP

  == domain 5  score: -1.6 bits;  conditional E-value: 2
       Big_5  67 itpsaeLaanttYtvtitagikDlag...n 93 
                 i  s +++++  Y++ i  gi+D+a    n
  EFC37630.1 895 IEYSVKFEKGGNYSFSI--GIVDSATgqtN 922
                 45557788899999999..99999953322 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 3.1
       Big_5   18 gvavnaeitvtFseav.......d 34  
                  gv+  a+i ++Fs a+       +
  EFC37630.1 1361 GVSI-ATIGINFSDAIekeirvfT 1383
                  5665.5999*****9944443333 PP

>> DUF11  Domain of unknown function DUF11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       1.6   3.6e+03      36      52 ..    1080    1136 ..    1069    1164 .. 0.61
   2 ?    1.9   0.0      0.12   2.8e+02      10      30 ..    1291    1311 ..    1284    1318 .. 0.85
   3 !   13.9   0.0   2.2e-05     0.049       4      48 ..    1812    1854 ..    1806    1874 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.6
       DUF11   36 tDtl....................................Paglayvsvsas....q 52  
                  +D++                                    P +++y++ s +     
  EFC37630.1 1080 KDPMtgapqegcevciiavdeavlsltnysisnpldtfvtPYNTTYQPYSLRnnvfV 1136
                  555555555555555555555555555555555558888899999999999843330 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.12
       DUF11   10 vrpGdtvtytltvtNtgpasa 30  
                  +++Gd v++t +++N+ + ++
  EFC37630.1 1291 LNFGDRVEFTCVLQNQTQLNL 1311
                  699************998877 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 2.2e-05
       DUF11    4 tvdksevrpGdtvtytltvtNtgpasangvvvtDtlPaglayvsv 48  
                    ++ ++++G+ +++ lt+tNt+ +    v + D lPagl+ +  
  EFC37630.1 1812 EKNTWRFKAGELIRVKLTMTNTSRRYH--VALVDYLPAGLEPINP 1854
                  33444999**************98877..**********997765 PP

>> Big_1  Bacterial Ig-like domain (group 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.47     1e+03      14      36 ..     337     359 ..     327     366 .. 0.79
   2 ?   -1.8   0.1       1.5   3.3e+03      25      43 ..     517     535 ..     513     536 .. 0.87
   3 ?    0.2   1.0      0.35   7.9e+02      28      51 ..     757     781 ..     756     796 .. 0.83
   4 ?   -2.8   0.0         3   6.7e+03      18      35 ..     787     804 ..     785     814 .. 0.66
   5 !   12.8   0.2   4.1e-05     0.092       7      35 ..     841     869 ..     837     880 .. 0.87
   6 !    5.9   0.0    0.0055        12      18      52 ..    1209    1246 ..    1208    1248 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.47
       Big_1  14 kDangnpvagatVtfsvsggals 36 
                 +D  g+++++ tV f+v g+  s
  EFC37630.1 337 VDVWGQVLKDLTVEFQVKGARQS 359
                 577799***********995544 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.5
       Big_1  25 tVtfsvsggalsassgtTd 43 
                 +Vtf  ++ ++s++ ++T+
  EFC37630.1 517 NVTFHFNNHTTSSPDAKTG 535
                 7*******99999999986 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.35
       Big_1  28 fsvsg.galsassgtTdanGkatvt 51 
                 fs+++   +++ +gtTd +G+ ++ 
  EFC37630.1 757 FSANSnVGVTTFEGTTDGDGEHQIA 781
                 788885445599********98776 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 3
       Big_1  18 gnpvagatVtfsvsggal 35 
                  n v+ a++t+sv +++ 
  EFC37630.1 787 SNRVKKAPITISVESTVQ 804
                 588999999999998333 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 4.1e-05
       Big_1   7 ntltatvkDangnpvagatVtfsvsggal 35 
                 +t++ +v+D +gn v+g+++ ++v+ +++
  EFC37630.1 841 ITASLIVTDIDGNLVSGIPIQLKVTTQVN 869
                 78999*******************98554 PP

  == domain 6  score: 5.9 bits;  conditional E-value: 0.0055
       Big_1   18 gnpvagatVtfsvsg.gals..assgtTdanGkatvtl 52  
                  g pv+ ++     s+ + l+  ++s++T+a+G ++v++
  EFC37630.1 1209 GMPVPEQPMIAVRSNfNPLAifSPSSKTNAEGFTSVKF 1246
                  7899999988888888666667************9987 PP

>> MG4  Macroglobulin domain MG4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.2      0.74   1.7e+03      49      84 ..     769     808 ..     753     815 .. 0.66
   2 ?   10.4   0.1   0.00025      0.55       7      40 ..     832     868 ..     828     888 .. 0.78
   3 ?   -1.9   0.0       1.7   3.8e+03      47      75 ..    1231    1259 ..    1209    1265 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.74
         MG4  49 slttdedGtakfsintpe.d...aksltitvktkdpslpe 84 
                 + ttd dG  ++ i  +e +   ++ +ti v+   +++ +
  EFC37630.1 769 EGTTDGDGEHQIAIAFEEsNrvkKAPITISVESTVQDINR 808
                 6799999999999999885243344455555555555543 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00025
         MG4   7 pkffKpGlPfsikVlvkdpdgspaknvpVkiea...l 40 
                  +f K+ +P +  + v+d dg+ ++++p+++++   +
  EFC37630.1 832 REFAKQNVPITASLIVTDIDGNLVSGIPIQLKVttqV 868
                 6799****************************94221 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.7
         MG4   47 keslttdedGtakfsintpedaksltitv 75  
                    s +t+++G  ++ + +p++ ++  it+
  EFC37630.1 1231 SPSSKTNAEGFTSVKFKIPDNLTKYRITA 1259
                  4567899**************99999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1949 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       555  (0.0309554); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.16u 0.35s 00:00:01.50 Elapsed: 00:00:00.56
# Mc/sec: 10556.62
//
Query:       EFC37631.1  [L=560]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.9e-12   46.6   0.0    1.5e-11   44.7   0.0    1.8  1  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.013   14.8   0.1      0.025   13.9   0.1    1.4  1  EcKinase        Ecdysteroid kinase
      0.028   14.0   0.1      0.056   13.0   0.1    1.5  1  Choline_kinase  Choline/ethanolamine kinase
      0.096   12.0   0.0        4.5    6.6   0.0    2.3  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.7   0.0   3.4e-15   1.5e-11       8     194 ..      34     274 ..      30     292 .. 0.71

  Alignments for each domain:
  == domain 1  score: 44.7 bits;  conditional E-value: 3.4e-15
                 .SSCEEEEEEETT.-.....-EEEEEE-TT..S-HHHHHHHHHHHHHHHHTT-B--B-CTTBS-EEETTE..EEEEEE----EE-SS...HHHHHHHHH CS
         APH   8 gasnrtylvttpa.g.....ryvlrrnppa..raaeeirrevallrlLakagvpvPevlagdtddeeigl..lfalieyvpgrsllr...klsaaqlpe 93 
                 g +n  + +   + g     ++vlr+++    +   ++r+ev++  + +kag+p+P+++ +  ++ee++l  ++ l+e+  g++l++    ls +q+ +
  EFC37631.1  34 GVINSIFMIRAVReGtlegvELVLRISNCHtfWKGISVRNEVKCILFAEKAGIPTPKIVSYSDNAEESPLgcEYILQERAKGQTLANswrFLSIKQKVQ 132
                 5566555555555445556899****999999**********************************************************99******* PP

                 HHHHHHHHHCCHHCH.......-STTTB-....................................SHHCHTCCHHHHHHCHHHCCCGCCTCC..HHHHH CS
         APH  94 llealgeflaalhqv......dpaalpla....................................dflaqdlellrqlesatarllaselld..lleel 148
                 lle+l+   ++lh        d      +                                    d   ++l++     ++  ++++ + +     e l
  EFC37631.1 133 LLEELIVIVGKLHTNsenkkdD-----YQvgsllgseksslgvivgdcaplgpfknlkemvieqiD---FTLNQISNTGEQ-VHYPHYLDFVslHSEPL 222
                 ***************3333331.....335555565566666666555555555555555432221...222222222222.23333333333322222 PP

                 HHHHHHHHHHH--S...SS-EEEE-SS-SGGGEEEC......TTEEEEE---T CS
         APH 149 eeqvlaalaallpg...elptvllHgDlhpgNllvd....pddgrvtGviDfe 194
                  + +  +l+ + +g   +   +++H+Dl+  N++++     d  +v++v+D+ 
  EFC37631.1 223 LD-LKSKLLHTDDGvedPNVYQFCHCDLNASNIMIKsnasLDTAKVSAVLDWP 274
                 22.44444444444777999****************9999666999******5 PP

>> EcKinase  Ecdysteroid kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   5.5e-06     0.025     209     254 ..     236     282 ..     182     283 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 5.5e-06
    EcKinase 209 ekeeefnvlnHGDlwvnNimfkydeeg.epedvilvDFQlsrygSpa 254
                  ++ +++ ++H Dl+ +Nim+k +++  + +    +D+  sr++S++
  EFC37631.1 236 VEDPNVYQFCHCDLNASNIMIKSNASLdTAKVSAVLDWPQSRFTSVV 282
                 556677789***************999455555678**999999985 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   1.2e-05     0.056     142     162 ..     239     259 ..     180     282 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
                     GG-EEEE-S--SGGGEEE.-C CS
  Choline_kinase 142 espvvfcHnDlqegNillnke 162
                      +   fcH+Dl  +Ni+ +++
      EFC37631.1 239 PNVYQFCHCDLNASNIMIKSN 259
                     34479************9554 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.013        59      57     141 ..      70     151 ..      56     170 .. 0.74
   2 ?    6.6   0.0     0.001       4.5     137     166 ..     242     273 ..     234     285 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.013
         Kdo  57 ravrEfrllkrLeeagvavpkpvaagavkvgle.yrAlllterlegaqdLedllakwaelaeelkrallkavgrliaklhragvnH 141
                  +++E++ +   e+ag+++pk+v +  ++++       +l er +g q   +l+++w+ l+ + k +ll+++  ++ klh    n 
  EFC37631.1  70 SVRNEVKCILFAEKAGIPTPKIVSYSDNAEESPlGCEYILQERAKG-Q---TLANSWRFLSIKQKVQLLEELIVIVGKLHTNSENK 151
                 5678999999999**********99988877664556677777666.3...44455666778888888888888888888766555 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.001
         Kdo 137 agvnHadlyaknillqqee..eeeaeiwliDl 166
                  + +H dl+a ni+++ ++  + +   +++D 
  EFC37631.1 242 YQFCHCDLNASNIMIKSNAslDTAKVSAVLDW 273
                 689*************9986544444556665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (560 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       512  (0.0285571); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.37s 00:00:01.05 Elapsed: 00:00:00.52
# Mc/sec: 3212.47
//
Query:       EFC37632.1  [L=1186]
Description: Hypothetical protein NAEGRDRAFT_74620 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.037   13.9   2.7       0.18   11.7   1.1    2.8  3  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   1.1     1e-05      0.18       4      35 ..       8      40 ..       5      46 .. 0.85
   2 ?   -1.5   0.0      0.14   2.5e+03       2      16 ..     390     404 ..     389     414 .. 0.82
   3 ?   -0.9   0.0     0.089   1.6e+03      11      28 ..     733     750 ..     732     752 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1e-05
  F-box-like  4 LPdEiLlq.IFsyLppsdLlrlalVCrrWrrva 35
                LP+E+L + I+ ++p ++L+ l+lVC+ +  ++
  EFC37632.1  8 LPPEVLTHsILAFIPHNSLIHLRLVCSEFDHFI 40
                9***88655*****************9987666 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.14
  F-box-like   2 srLPdEiLlqIFsyL 16 
                  +LP   Ll++F + 
  EFC37632.1 390 IDLPSSYLLDVFKFF 404
                 58**********864 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.089
  F-box-like  11 qIFsyLppsdLlrlalVC 28 
                 q++ yLp+  L+rl  VC
  EFC37632.1 733 QVLKYLPFVGLIRLNPVC 750
                 899***********9999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.89u 0.36s 00:00:01.25 Elapsed: 00:00:00.55
# Mc/sec: 6519.67
//
Query:       EFC37633.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.41   10.8   3.0         11    6.2   0.1    2.4  2  LZ3wCH    Leucine zipper with capping helix domain


Domain annotation for each model (and alignments):
>> LZ3wCH  Leucine zipper with capping helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.3    0.0022        40       8      26 ..     109     128 ..     104     131 .. 0.77
   2 ?    6.2   0.1    0.0006        11      38      49 ..     250     261 ..     244     262 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.0022
      LZ3wCH   8 katkkakeaanrWtd.nifd 26 
                 ++++ +++ +  Wtd ++ +
  EFC37633.1 109 ENYELYRKFVSWWTDaIARM 128
                 67899**********53333 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0006
      LZ3wCH  38 skkelneefgIe 49 
                 sk+el+e+fgI+
  EFC37633.1 250 SKEELKEQFGID 261
                 89*********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       658  (0.0367003); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1670.19
//
Query:       EFC37634.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.5e-06   26.3   0.4    1.7e-05   25.0   0.4    1.8  1  V-SNARE_C       Snare region anchored in the vesicle membrane
    1.3e-05   25.1   3.3    3.1e-05   23.8   2.9    1.7  1  Use1            Membrane fusion protein Use1
     0.0004   20.3   0.7     0.0023   17.8   0.0    2.3  2  Sec20           Sec20
  ------ inclusion threshold ------
      0.013   16.1   5.0       0.31   11.7   0.1    2.4  2  HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interac
       0.13   12.1   4.7       0.97    9.3   1.2    2.2  2  Apolipoprotein  Apolipoprotein A1/A4/E domain
       0.15   12.3   2.4        5.4    7.3   0.2    2.8  2  WXG100          Proteins of 100 residues with WXG
       0.25   11.5   4.8        1.7    8.8   1.9    2.5  2  Uds1            Up-regulated During Septation
       0.33   11.0   7.1        0.4   10.8   4.2    2.1  2  MAS20           MAS20 protein import receptor
       0.36   11.5   6.1        3.4    8.3   1.5    2.9  2  ING             Inhibitor of growth proteins N-terminal histo
       0.45    9.0   5.9      0.057   11.9   1.8    1.5  2  Herpes_UL25     Herpesvirus UL25 family
       0.68    9.6  16.6       0.63    9.7  10.3    2.2  2  YkyA            Putative cell-wall binding lipoprotein
        1.1    8.0   5.1        1.5    7.6   5.1    1.1  1  DUF4551         Protein of unknown function (DUF4551)
        1.5    9.0   7.4       0.38   11.0   0.4    2.3  2  DUF3958         Protein of unknown function (DUF3958)
        2.3    8.6   7.6        2.7    8.3   0.3    2.9  3  Tup_N           Tup N-terminal
        2.6    7.7  11.7        3.3    7.4   1.1    2.8  2  DUF745          Protein of unknown function (DUF745)
          3    8.3   8.4        2.9    8.3   3.7    2.7  2  V-SNARE         Vesicle transport v-SNARE protein N-terminus
        3.2    7.2  10.5         26    4.2  10.5    2.0  1  Lin-8           Ras-mediated vulval-induction antagonist
        4.6    7.1  10.0        0.5   10.2   4.4    2.3  2  Synaptobrevin   Synaptobrevin
        8.9    4.4   7.8       0.28    9.4   0.4    2.2  3  Fusion_gly      Fusion glycoprotein F0


Domain annotation for each model (and alignments):
>> V-SNARE_C  Snare region anchored in the vesicle membrane C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.4   1.8e-08   1.7e-05       3      60 ..     193     250 ..     191     254 .. 0.92

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 1.8e-08
   V-SNARE_C   3 llresdrlknShrivdetisiGaailedLhsQretLkrarsklhnvanrlgksnsiLr 60 
                 + + +d+l+n + + de+i+ Gaa  e+L++Q e+++ +++ l ++++ l+++++ L+
  EFC37634.1 193 YDKNNDMLNNMIKMGDEMIQVGAAAAEKLRQQTERMNAIQKDLDDLGDGLKRAKKELN 250
                 6899**********************************************99998666 PP

>> Use1  Membrane fusion protein Use1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   2.9   3.3e-08   3.1e-05      49     244 ..      65     277 ..      28     278 .. 0.59

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 3.3e-08
        Use1  49 pskevlkeYse.kveaLkllleaeklssteekalanqllapg................eeskeekeeskereeaskelrqkekakyqkelrkellgknd 130
                  +k+ l++Y+  k  + ++ l++ ++s  ++      +++++                +               s + + ++++ +++++ +   ++++
  EFC37634.1  65 FAKDDLNDYTGnKKRTFQQELKKLEQS-VSKNYADLTQIKENrepaagsaspansttsS---------------SGNRKPTKTSGSTNDVPSAGKSSGT 147
                 455566666531333333333333333.2222222233333222222222222222221...............1111122222222222222222222 PP

        Use1 131 sssspekekeskkk.......................ksdedldavlkkhenlqEklaeemlsLarnLKenslaasqiikkDtetlsksekaadqnlas 206
                 +++ +++++    +                       k    +d+vl  + +   ++ ++m+++  ++ +   aa + +++ te +++ +k  d+  + 
  EFC37634.1 148 KNQPKRNDD----HdeiqitnlddddngggsgpkqmqKGHSRVDEVLDIYDK-NNDMLNNMIKMGDEMIQVGAAAAEKLRQQTERMNAIQKDLDDLGDG 241
                 222222111....012335555555556666666676888889999998866.567889**************************************** PP

        Use1 207 lkkeserleeh.skskvkcllwlllfvvlvvFismvlfi 244
                 lk++++ l+   +  +++  +++++++v+   i+mvl+i
  EFC37634.1 242 LKRAKKELNAFmRGTACDKAVVIIFIIVI---IAMVLLI 277
                 **********7699999998888777776...6788887 PP

>> Sec20  Sec20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.79   7.5e+02      35      59 ..      46      70 ..      20      85 .. 0.78
   2 !   17.8   0.0   2.4e-06    0.0023      18      88 ..     208     278 ..     194     282 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.79
       Sec20 35 tkslekleeeykqvedvlsrskklv 59
                   ++k+e+ yk+ ++ +s +k+ +
  EFC37634.1 46 DTLIKKAESAYKGAKENISFAKDDL 70
                4568999999999999999887655 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 2.4e-06
       Sec20  18 sqevqqSeenleeldastkslekleeeykqvedvlsrskklvkklerrdktdkllvflalglflacvvyvv 88 
                  + +q  + ++e+l+++t+ +++++ ++ ++ d l+r+kk ++ + r    dk  v++ +  ++a+v+ ++
  EFC37634.1 208 DEMIQVGAAAAEKLRQQTERMNAIQKDLDDLGDGLKRAKKELNAFMRGTACDKAVVIIFIIVIIAMVLLII 278
                 4568889999**********************************************999999999998776 PP

>> HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interacting protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   1.3     0.026        25      19      76 ..      50     107 ..      35     122 .. 0.81
   2 ?   11.7   0.1   0.00033      0.31      24      76 ..     198     250 ..     192     259 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.026
  HIP1_clath_bdg  19 rqaqeeverekkeleeelerlkeeaerkleeqkeelekLkreleakraelarlkssLe 76 
                     ++a +  + +k+++++  ++l++ + +k +  ++el+kL++ + ++ a+l+++k+  e
      EFC37634.1  50 KKAESAYKGAKENISFAKDDLNDYTGNKKRTFQQELKKLEQSVSKNYADLTQIKENRE 107
                     5666667778999999999999999999999999999999999999999999998655 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00033
  HIP1_clath_bdg  24 everekkeleeelerlkeeaerkleeqkeelekLkreleakraelarlkssLe 76 
                     ++ ++  ++ +e+ ++ + a +kl++q+e +++++++l +  + l+r+k+ L+
      EFC37634.1 198 DMLNNMIKMGDEMIQVGAAAAEKLRQQTERMNAIQKDLDDLGDGLKRAKKELN 250
                     56666678999*****************************9999999999886 PP

>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   1.2     0.001      0.97      86     143 ..      37      94 ..       7     114 .. 0.58
   2 ?    4.1   0.1     0.041        38      70     105 ..     209     243 ..     192     256 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.001
                     HHHCHHCCHHCHCCHCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH---- CS
  Apolipoprotein  86 laadaeelqeqlavyaeelrerlerhvealkarlapyveelrqklaerleelkeslap 143
                      +a ++e +++l ++ae + ++++++++  k+ l  y+ + +   +++l+ l++s+  
      EFC37634.1  37 SKASSKEQRDTLIKKAESAYKGAKENISFAKDDLNDYTGNKKRTFQQELKKLEQSVSK 94 
                     2335566666666666666666666666666666666666666666666666666654 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.041
                     HHHHHCCHHHHHHHHHHHHCHHCCHHCHCCHCHHHH CS
  Apolipoprotein  70 elrqrlapyteelrerlaadaeelqeqlavyaeelr 105
                     e+ q  a+++e+lr++ + +++++q+ l+  +++l+
      EFC37634.1 209 EMIQVGAAAAEKLRQQTE-RMNAIQKDLDDLGDGLK 243
                     445555566666666544.66666666666666554 PP

>> WXG100  Proteins of 100 residues with WXG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1     0.071        67      40      73 ..      72     105 ..      50     112 .. 0.88
   2 ?    7.3   0.2    0.0058       5.4       6      46 ..     218     258 ..     215     262 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.071
                 GCTHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      WXG100  40 gWsGaaadafqaefeewkqaaqklvdaLeeisea 73 
                 ++ G+ + +fq+e++++ q++ k ++ L++i e+
  EFC37634.1  72 DYTGNKKRTFQQELKKLEQSVSKNYADLTQIKEN 105
                 6789999999999999999999999999999886 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0058
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCGCGCTHHHC CS
      WXG100   6 peelrqaaarfqkqaeeledelqrlkaevdalqsgWsGaaa 46 
                 +e+lrq   r+++++++l d+ + lk+  ++l++  +G+a 
  EFC37634.1 218 AEKLRQQTERMNAIQKDLDDLGDGLKRAKKELNAFMRGTAC 258
                 68899999999999999999999999999999999999885 PP

>> Uds1  Up-regulated During Septation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   1.9    0.0018       1.7      47     112 ..      26     106 ..      17     112 .. 0.75
   2 ?    3.0   0.1      0.12   1.1e+02      78     113 ..     215     250 ..     174     255 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0018
        Uds1  47 etklrdaarsLsrlyssskksak...............ssaarsnskssreslakaeeelaeserkvdelaselekleera 112
                  + lrda  +Ls+++s++++++                s+a+++ +  + +++++ ++el+++e++v +  ++l +++e++
  EFC37634.1  26 DKLLRDAVYNLSKASSKEQRDTLikkaesaykgakeniSFAKDDLNDYTGNKKRTFQQELKKLEQSVSKNYADLTQIKENR 106
                 5669***********666666558888888888777776666666666666677778888888888888888888887765 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.12
        Uds1  78 kssreslakaeeelaeserkvdelaselekleeraa 113
                 +   e+l++++e +++ ++  d+l + l++++++++
  EFC37634.1 215 AAAAEKLRQQTERMNAIQKDLDDLGDGLKRAKKELN 250
                 445567888888888888888888888888887776 PP

>> MAS20  MAS20 protein import receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   4.2   0.00043       0.4      13      89 ..      17      95 ..      14     108 .. 0.81
   2 ?    0.5   0.0      0.63   5.9e+02      69      90 ..     194     215 ..     147     236 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00043
       MAS20 13 vYFDrkRrsdpefkkklrerrkkqakaakeeeeaekaekkk..kealeeakeelptdaeevekfFleevqlGEellaqg 89
                vYFD+ + +d+  +  + + +k+ +k+++++  ++++++ k  ke ++ ak++l + + ++++ F +e+++ E+ ++++
  EFC37634.1 17 VYFDEIKEKDKLLRDAVYNLSKASSKEQRDTLIKKAESAYKgaKENISFAKDDLNDYTGNKKRTFQQELKKLEQSVSKN 95
                9***************999999888777666655555555566667777777799999****************99984 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.63
       MAS20  69 eevekfFleevqlGEellaqge 90 
                 ++   ++ + +++G+e+++ g 
  EFC37634.1 194 DKNNDMLNNMIKMGDEMIQVGA 215
                 5666778888999999998843 PP

>> ING  Inhibitor of growth proteins N-terminal histone-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   1.5    0.0036       3.4      14      46 ..      13      59 ..       5     107 .. 0.68
   2 ?    4.1   0.2     0.072        68      61      96 ..     195     230 ..     175     239 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0036
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..............T CS
         ING 14 lelqrnltelreiDakvqellkeidskiekfl..............k 46
                + +q +++e++e+D+ +++++ ++++  +k                +
  EFC37634.1 13 DGIQVYFDEIKEKDKLLRDAVYNLSKASSKEQrdtlikkaesaykgA 59
                66899*****************9965555544333344433333330 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.072
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         ING  61 riqeelkeaqelldeKiqlaqqaldlvdkhlrrLdq 96 
                 + +++l+++++++de iq+   a++ ++++++r+++
  EFC37634.1 195 KNNDMLNNMIKMGDEMIQVGAAAAEKLRQQTERMNA 230
                 456788999999999999999999999999999886 PP

>> Herpes_UL25  Herpesvirus UL25 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   1.8     6e-05     0.057      48     141 ..      75     164 ..      37     170 .. 0.74
   2 ?   -2.7   0.1       1.6   1.5e+03      40      63 ..     217     240 ..     192     251 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 6e-05
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXX--EE................E-SST CS
  Herpes_UL25  48 evkkralraeLdnlaqkavalaeeierrlkevEellekiaeleaaaaaee.aaaarpplspssaspltavasaeevgkgkesrddeiagevaIvk 141
                    kkr  ++eL++l+q + ++     ++l++++e+ e +a + ++a++   ++ +r+p+++s +  ++  a++++++k++ +r+d+ + e++I+ 
   EFC37634.1  75 GNKKRTFQQELKKLEQSVSKNY----ADLTQIKENREPAAGSASPANSTTsSSGNRKPTKTSGSTNDVPSAGKSSGTKNQPKRNDD-HDEIQITN 164
                  4699999999999999988775....677888888888888855555544044455999999999999999999988888888765.67888876 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.6
                  XXXXXXXXXXXXXXXXXXXXXXXX CS
  Herpes_UL25  40 sreevevlevkkralraeLdnlaq 63 
                  ++e+++ ++ + +a++ +Ld+l  
   EFC37634.1 217 AAEKLRQQTERMNAIQKDLDDLGD 240
                  567788888888888888888865 PP

>> YkyA  Putative cell-wall binding lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  10.3   0.00067      0.63      26     119 ..       7     101 ..       1     105 [. 0.88
   2 ?    3.6   0.4      0.05        47      68      96 ..     216     240 ..     176     255 .. 0.43

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00067
        YkyA  26 kLtelekkeqelyeeiielgmdefdkikklsdealenveeReellekekesieeakeefekikeeieei...edeelkkeaeelieameeryeaydk 119
                 ++ e+e   q +++ei e+++   d++ +ls+   ++ e+R +l++k + + + ake+++ +k++++++   ++ + ++e+++l++++ + y+   +
  EFC37634.1   7 SIDEAEDGIQVYFDEIKEKDKLLRDAVYNLSKA--SSKEQRDTLIKKAESAYKGAKENISFAKDDLNDYtgnKKRTFQQELKKLEQSVSKNYADLTQ 101
                 678889999999999999988889999999986..5679******************************99888899*************9998766 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.05
        YkyA  68 ellekekesieeakeefekikeeieeied 96 
                        e + +  e ++ i+++++++ d
  EFC37634.1 216 AAA----EKLRQQTERMNAIQKDLDDLGD 240
                 222....2244444444444444444432 PP

>> DUF4551  Protein of unknown function (DUF4551)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   5.1    0.0016       1.5     105     239 ..      23     159 ..      14     201 .. 0.49

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0016
     DUF4551 105 kselllskdkkselfkvspskasekksrressgaa..kkssslnessl.dakekeek.tvskksqlslsl.selrklseeekeelesekalks....lr 194
                 k++++l +d+  +l+k+s +++ ++  ++  s+ +  k+++s+ + +l d + ++++ ++++ ++l++s  ++  +l++ ++++++   + +     ++
  EFC37634.1  23 KEKDKLLRDAVYNLSKASSKEQRDTLIKKAESAYKgaKENISFAKDDLnDYTGNKKRtFQQELKKLEQSVsKNYADLTQIKENREPAAGSASPanstTS 121
                 444555567777888888887777777777776667788888888888544443333044445556666543444444444444444433333221344 PP

     DUF4551 195 sasrplPesllsrapkppsspkeppssslskderdskseessqve 239
                 s++ ++P++ + ++ + ps  k++        ++++ ++++++ e
  EFC37634.1 122 SSGNRKPTKTSGSTNDVPSAGKSS-------GTKNQPKRNDDHDE 159
                 555556655522222222222211.......11111111111222 PP

>> DUF3958  Protein of unknown function (DUF3958)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   1.7      0.51   4.8e+02      64      93 ..      70      99 ..      20     107 .. 0.60
   2 ?   11.0   0.4    0.0004      0.38      43     107 .]     184     249 ..     177     249 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.51
     DUF3958 64 lrdevqrlsrklredLEeeeeeLkrekrqL 93
                l+d +  ++r  +++L + e+   + + +L
  EFC37634.1 70 LNDYTGNKKRTFQQELKKLEQSVSKNYADL 99
                445555555555555544444444444444 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.0004
     DUF3958  43 rlfdelletfrkd.eeshlfeklrdevqrlsrklredLEeeeeeLkrekrqLedqeeelyyekrkl 107
                   +de+l  + k+ ++ + + k+ de+++      e+L ++ e+++  +++L d  + l ++k+ l
  EFC37634.1 184 SRVDEVLDIYDKNnDMLNNMIKMGDEMIQVGAAAAEKLRQQTERMNAIQKDLDDLGDGLKRAKKEL 249
                 55799999999999*****************************************99999999975 PP

>> Tup_N  Tup N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       4.7   4.4e+03      43      57 ..      28      42 ..       9      47 .. 0.70
   2 ?    3.6   0.5     0.088        83      18      46 ..      76     104 ..      59     106 .. 0.69
   3 ?    8.3   0.3    0.0029       2.7      30      61 ..     217     248 ..     185     252 .. 0.66

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 4.7
       Tup_N 43 qirqtlyeLeeahrk 57
                 +r ++y+L +a +k
  EFC37634.1 28 LLRDAVYNLSKASSK 42
                578888888877655 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.088
       Tup_N  18 qeasslkaqkdeyelkiqsqiqElqqirq 46 
                 ++  +++++ + +e+++++++++l+qi++
  EFC37634.1  76 NKKRTFQQELKKLEQSVSKNYADLTQIKE 104
                 34455777888888888888888888886 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0029
       Tup_N  30 yelkiqsqiqElqqirqtlyeLeeahrkikqq 61 
                    k+++q++ +++i++ l +L    ++ k++
  EFC37634.1 217 AAEKLRQQTERMNAIQKDLDDLGDGLKRAKKE 248
                 4568******************8887777765 PP

>> DUF745  Protein of unknown function (DUF745)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   3.6     0.036        34     107     180 ..      47     117 ..       7     120 .. 0.59
   2 ?    7.4   1.1    0.0035       3.3     110     164 ..     197     251 ..     177     262 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.036
      DUF745 107 ealkallkaakenlenaeqvaagaqqelaektqlleaAkkRveeLkkqlkearkdlektkkaAykAacAAqeAk 180
                 + +k++  a+k + en+  +++  +    +k+    + ++ +++L++ +++  +dl+++k++ + Aa +A+ A+
  EFC37634.1  47 TLIKKAESAYKGAKENISFAKDDLNDYTGNKKR---TFQQELKKLEQSVSKNYADLTQIKENREPAAGSASPAN 117
                 233333333334444444444444444444443...45778899999999999999999999999999999886 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0035
      DUF745 110 kallkaakenlenaeqvaagaqqelaektqlleaAkkRveeLkkqlkearkdlek 164
                 +++l+++ +  +++ qv a a+++l+++t+ ++a +k ++ L   lk a+k+l++
  EFC37634.1 197 NDMLNNMIKMGDEMIQVGAAAAEKLRQQTERMNAIQKDLDDLGDGLKRAKKELNA 251
                 578899999999999************************************9987 PP

>> V-SNARE  Vesicle transport v-SNARE protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   3.7    0.0031       2.9      11      72 ..      32      94 ..      23     101 .. 0.85
   2 ?    1.3   0.2      0.47   4.4e+02      21      48 ..     222     249 ..     210     255 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0031
     V-SNARE 11 klarlsslag.eerkaalreiekkldeaeelldqMelEvrnlpsserasykaklreykselkk 72
                ++ +ls++++ e+r  +++++e++ + a+e ++     +++   + + ++++ l+   + + k
  EFC37634.1 32 AVYNLSKASSkEQRDTLIKKAESAYKGAKENISFAKDDLNDYTGNKKRTFQQELKKLEQSVSK 94
                45567777766*******************************999999999999998887766 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.47
     V-SNARE  21 eerkaalreiekkldeaeelldqMelEv 48 
                  ++ + ++ i+k+ld++ + l++   E+
  EFC37634.1 222 RQQTERMNAIQKDLDDLGDGLKRAKKEL 249
                 4777778888888888777776665555 PP

>> Lin-8  Ras-mediated vulval-induction antagonist
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2  10.5     0.027        26     152     287 ..      85     235 ..       8     238 .. 0.63

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.027
       Lin-8 152 aeegedteeeekveveeeaeeqgsmdlketeaeevkeeqmeqsfe............eeeeakleeptvniveee...aaaravdqsfgsaeqqlesss 235
                 +++ e++  +++ +  + +e+ + + ++ ++a+   +++ +++ +            ++ +  +++p  n   +e   ++  + d+  gs+++q+++  
  EFC37634.1  85 LKKLEQSVSKNYADLTQIKENREPAAGSASPANSTTSSSGNRKPTktsgstndvpsaGKSSGTKNQPKRNDDHDEiqiTNLDDDDNGGGSGPKQMQKGH 183
                 3333333333333333333333333333333333333333333324444555566664444555555554444440003344445556677777799** PP

       Lin-8 236 srtssassssssaapsstaakdfeeemkqIteqakriareqPervkliRkaL 287
                 sr++++    ++++   +++ ++ +em q++  a   +r+q er++ i k L
  EFC37634.1 184 SRVDEVLDIYDKNNDMLNNMIKMGDEMIQVGAAAAEKLRQQTERMNAIQKDL 235
                 **********************************************999877 PP

>> Synaptobrevin  Synaptobrevin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.3       4.2   3.9e+03       6      28 ..      79     101 ..      76     107 .. 0.73
   2 ?   10.2   4.4   0.00053       0.5       4      87 ..     188     274 ..     177     280 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 4.2
                    HHHHHHHHCCCCHHCCHHHHCHC CS
  Synaptobrevin   6 akikaevdevkdimkeNidkvle 28 
                    ++ ++e+++ ++ + +N  ++++
     EFC37634.1  79 RTFQQELKKLEQSVSKNYADLTQ 101
                    56788888888888888877766 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00053
                    HHHHHHHHHHCCCCHHCCHHHHCHCCCCC.HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHTX..XXXXXXXXXXXXXXXXXXXXX CS
  Synaptobrevin   4 klakikaevdevkdimkeNidkvlergek.ldeLvdktenLqssaqqFkkqarklkrkmwwknm..kliiililvvlililiiiivi 87 
                    ++  i ++ ++  + m++  d++++ g    ++L ++te++++  ++       lkr+    n   + +++  +vv+i+i++ii+++
     EFC37634.1 188 EVLDIYDKNNDMLNNMIKMGDEMIQVGAAaAEKLRQQTERMNAIQKDLDDLGDGLKRAKKELNAfmRGTACDKAVVIIFIIVIIAMV 274
                    555566666677778888889999998652799********************9999887766533666666666666666666554 PP

>> Fusion_gly  Fusion glycoprotein F0
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.2      0.74     7e+02     425     455 ..      53      91 ..      21      97 .. 0.73
   2 ?    9.4   0.4   0.00029      0.28     436     487 .]     226     277 ..     194     278 .. 0.82
   3 ?   -1.9   0.1      0.79   7.4e+02     332     349 ..     286     303 ..     283     312 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.74
                 -........B---SHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Fusion_gly 425 p........pisveevdisaelskvnesleqskdllees 455
                           is+ ++d++   ++ +   +q +++le+s
  EFC37634.1  53 EsaykgakeNISFAKDDLNDYTGNKKRTFQQELKKLEQS 91 
                 334444455899999999999999999999999999998 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00029
                 HHHHHHHHHHHHHHHHHHHHCCCCTCCCHHHHHTTXXXXXXXXXXXXXXXXX CS
  Fusion_gly 436 aelskvnesleqskdlleesnkiLdsvnkkllstaivivlivlvivvlllsl 487
                   +++++++l++  d l++++k L+   ++ +  ++v+++ ++vi++++l +
  EFC37634.1 226 ERMNAIQKDLDDLGDGLKRAKKELNAFMRGTACDKAVVIIFIIVIIAMVLLI 277
                 567889999***********************99999999999999988754 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.79
                 HHHTT-GGGSEEEE-SST CS
  Fusion_gly 332 eClsgstsaCkvskvkss 349
                  C++gst++C    ++s+
  EFC37634.1 286 FCIKGSTNKCIAGFTASN 303
                 5*********87665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2261  (0.126109); expected 358.6 (0.02)
Passed bias filter:                      988  (0.0551063); expected 358.6 (0.02)
Passed Vit filter:                       124  (0.00691617); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.74u 0.31s 00:00:01.05 Elapsed: 00:00:00.50
# Mc/sec: 2112.94
//
Query:       EFC37635.1  [L=436]
Description: phenylalanine 4-monooxygenase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   8.1e-157  521.4   0.0   9.8e-157  521.2   0.0    1.1  1  Biopterin_H  Biopterin-dependent aromatic amino acid hydroxyl
    2.1e-05   24.2   0.0    4.3e-05   23.2   0.0    1.6  1  ACT          ACT domain


Domain annotation for each model (and alignments):
>> Biopterin_H  Biopterin-dependent aromatic amino acid hydroxylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  521.2   0.0  1.1e-160  9.8e-157       1     330 [.      88     426 ..      88     427 .. 0.98

  Alignments for each domain:
  == domain 1  score: 521.2 bits;  conditional E-value: 1.1e-160
  Biopterin_H   1 pwfPrkisdlDklaklvlkygaeldadhpgfkDkeyrkrrkeiadialnykhgepiprveyteeeiktWkevykklkklypthaCkeyleafklleke 98 
                  pwfPrkisd+D +++++l++g +l++dhpgf+Dkeyr+rrk+i+dia+nykhgepipr++yt++e++tWk+vy+kl++lyp++aC++y++ f+l++++
   EFC37635.1  88 PWFPRKISDIDFFTRQTLEAGGDLESDHPGFHDKEYRDRRKMISDIAINYKHGEPIPRIQYTQNENNTWKVVYEKLTELYPKYACEQYNYLFPLFQEN 185
                  8************************************************************************************************* PP

  Biopterin_H  99 cgysedniPqledvskfLkektGfklRPvaGllsaRdfLaglafrvfqstqYiRhsskplytpePdvvhellGhvplladkefaqfsqeiglaslGas 196
                  cg++++niPql+dv++fL e tGf+ RPvaGllsaRdfL+glafrvf+stqYiRh+s+p+ytpePdvvhellGh  +lad++fa+fsq+iglaslGas
   EFC37635.1 186 CGFRAENIPQLQDVNDFLVEVTGFRYRPVAGLLSARDFLNGLAFRVFHSTQYIRHHSSPFYTPEPDVVHELLGHSIMLADPDFAEFSQQIGLASLGAS 283
                  ************************************************************************************************** PP

  Biopterin_H 197 deeieklatlywftvefglckqngelkaygaGllssygelkyalsdk........pevkpfdpektaeqeyqiteyqpvYfvaesfedakeklrkfak 286
                  d +i++l++lyw+++efgl+k+n+elkaygaGllss+gel+++++ k        pe+++f p+++ae++y+it+yqp+Y+v++s+e++ke ++ f++
   EFC37635.1 284 DADIDRLVRLYWYCLEFGLVKENNELKAYGAGLLSSFGELEFSCTGKdrngkvppPEYRNFVPTEAAERSYPITHYQPMYYVVDSLESCKELIKGFTM 381
                  *********************************************96666667779****************************************98 PP

  Biopterin_H 287 t.lkrpfsvrydpytqsvevldskekikkllkelkeelklleeal 330
                  + l+++f v+y+pyt++v+vlds++k+ +l+k+++++l+l+++al
   EFC37635.1 382 NnLEKEFVVKYNPYTNTVDVLDSEAKLIALTKTVQNNLDLISTAL 426
                  77***************************************9998 PP

>> ACT  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.0   4.8e-09   4.3e-05       2      55 ..       7      58 ..       6      69 .. 0.87

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 4.8e-09
                EEEEEEESSTTHHHHHHHHHHHTTSEEEEEEEEEESTTECEEEEEEEEEEHHHH CS
         ACT  2 vlrvgvpDrPGlLarvfgaladrgiNidsieqrssedkvagivfvvivvdeedl 55
                +l++ +p r+G+L   + ++++++iN+++ie+++s+    ++vf ++v  +e++
  EFC37635.1  7 SLLITLPHRVGALKSSLDTFSKHNINLTKIESKPSKI--STRVFNFHVDIDEQA 58
                6889999****************************99..688888888777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (436 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       489  (0.0272742); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2597.26
//
Query:       EFC37636.1  [L=489]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-32  110.4   0.2    9.7e-06   26.1   0.5    7.9  7  RCC1      Regulator of chromosome condensation (RCC1) repeat
    6.1e-24   83.2  18.1    1.2e-07   31.4   0.7    5.8  5  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    8.7e-05   22.5   0.4    0.00098   19.1   0.0    2.7  3  DUF5074   Domain of unknown function (DUF5074)
  ------ inclusion threshold ------
      0.082   12.5   0.1       0.24   11.0   0.0    1.8  2  SH3_1     SH3 domain
       0.19   12.1   2.4          7    7.3   0.2    3.6  3  Reg_prop  Two component regulator propeller


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.0   0.00022       0.8       5      50 .]      87     135 ..      86     135 .. 0.86
   2 !   26.1   0.5   2.7e-09   9.7e-06       1      49 [.     138     187 ..     138     188 .. 0.84
   3 !   19.2   0.0     4e-07    0.0014       1      49 [.     191     238 ..     191     239 .. 0.92
   4 !    7.8   0.0    0.0014       5.1      18      50 .]     254     288 ..     244     288 .. 0.87
   5 !    9.2   0.0   0.00054       1.9      21      48 ..     303     328 ..     291     329 .. 0.82
   6 !   14.9   0.0   8.9e-06     0.032       5      48 ..     337     381 ..     333     383 .. 0.74
   7 !   11.8   0.0     8e-05      0.29       1      27 [.     386     414 ..     386     443 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00022
                 EEEE--GGGTTSSSS-....--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   5 ysWGrndyGqLGlgtt....esvlvPtkveglsgnrvvkvacGddhtval 50 
                 +  G+ndy qL  g +     ++++ ++++++ + +v+++a Gd+h+++l
  EFC37636.1  87 FVTGKNDYLQLVAGEKviydFTCHLDQQLKFSLD-DVIHIANGDNHSIFL 135
                 6679999999999999888877788899999885.************986 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 2.7e-09
                 TTEEEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt.esvlvPtkveglsgnrvvkvacGddhtva 49 
                 dG+ ++ G+n++GqLG  +    vl   k++ +++ r++kvacG++h++ 
  EFC37636.1 138 DGKAFGIGSNTQGQLGEFNVeFGVLFEIKIKQSKRGRITKVACGSFHSII 187
                 89***************555534444459***9999************86 PP

  == domain 3  score: 19.2 bits;  conditional E-value: 4e-07
                 TTEEEEEE--GGGTTSSSS-..--EEEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt..esvlvPtkveglsgnrvvkvacGddhtva 49 
                 dG+++  G n+++qLG+  +  ++    tkve+ ++ ++++++  ++ht++
  EFC37636.1 191 DGSIWVTGDNSFHQLGIEVDhlKCF---TKVEFQQDSPISHISTSYSHTLC 238
                 8****************55556999...******999************97 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.0014
                 SS---EEEEEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1  18 gttesvlvPtkveglsgn..rvvkvacGddhtval 50 
                 g++ +  +P ++++++++  + ++v +G++++++l
  EFC37636.1 254 GDDTEYFTPHRLTFFDDKdfKLTSVNAGYRYSAFL 288
                 67788899********99**************986 PP

  == domain 5  score: 9.2 bits;  conditional E-value: 0.00054
                 --EEEEEE-GGGTTS-EEEEEEETTEEE CS
        RCC1  21 esvlvPtkveglsgnrvvkvacGddhtv 48 
                  +v  Pt++++++  + v+v++G+ h +
  EFC37636.1 303 YNVFEPTQLNLFE--PLVQVFSGGKHLF 328
                 46678********..***********87 PP

  == domain 6  score: 14.9 bits;  conditional E-value: 8.9e-06
                 EEEE--GGGTTSSSS-.--EEE.EEE-GGGTTS-EEEEEEETTEEE CS
        RCC1   5 ysWGrndyGqLGlgtt.esvlv.PtkveglsgnrvvkvacGddhtv 48 
                 y+ G nd+ qL   +     ++ P+++++++ + v+++a+G++ht+
  EFC37636.1 337 YGLGMNDDKQLPFSKViT-GTIePQLLQLPTHEQVSDMAAGSYHTA 381
                 666666666666666632.2225********99************8 PP

  == domain 7  score: 11.8 bits;  conditional E-value: 8e-05
                 TTEEEEEE--GGGTTSSSS-...--EEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt...esvlvPt 27 
                 +G++y +G+++ Gq Glg++    ++ +P 
  EFC37636.1 386 SGNIYVCGWSELGQTGLGKNtitADC-TPL 414
                 59***************999876444.343 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.3   2.1e-09   7.7e-06       1      30 []     122     151 ..     122     151 .. 0.96
   2 !   31.4   0.7   3.3e-11   1.2e-07       1      30 []     175     204 ..     175     204 .. 0.96
   3 ?    3.3   0.1     0.021        74       2      24 ..     227     250 ..     226     256 .. 0.85
   4 !    7.0   0.0    0.0015       5.2       3      24 ..     277     298 ..     276     301 .. 0.92
   5 !   24.4   0.8   5.1e-09   1.8e-05       1      30 []     370     399 ..     370     399 .. 0.96

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 2.1e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V++++ Gd+Hs++Lt+dG+ ++ GsN+ GQ
  EFC37636.1 122 VIHIANGDNHSIFLTSDGKAFGIGSNTQGQ 151
                 788899***********************9 PP

  == domain 2  score: 31.4 bits;  conditional E-value: 3.3e-11
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +++v++G++Hs++L +dG ++ +G+Ns+ Q
  EFC37636.1 175 ITKVACGSFHSIILNSDGSIWVTGDNSFHQ 204
                 689************************987 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.021
      RCC1_2   2 ksvsaGdyHscaLte.dGeVlcWG 24 
                  ++s  ++H++  +e d+++++ G
  EFC37636.1 227 SHISTSYSHTLCYSErDNILYSMG 250
                 6799********997478899988 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0015
      RCC1_2   3 svsaGdyHscaLtedGeVlcWG 24 
                 sv aG++ s +Lt++ +V+  G
  EFC37636.1 277 SVNAGYRYSAFLTSNHTVYIMG 298
                 89****************9877 PP

  == domain 5  score: 24.4 bits;  conditional E-value: 5.1e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V +++aG+yH+   t++G+++ +G+ + GQ
  EFC37636.1 370 VSDMAAGSYHTALTTSSGNIYVCGWSELGQ 399
                 6789*************************9 PP

>> DUF5074  Domain of unknown function (DUF5074)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.56     2e+03      46     102 ..      52     109 ..      36     116 .. 0.54
   2 !   19.1   0.0   2.7e-07   0.00098       2      64 ..     187     252 ..     186     277 .. 0.79
   3 ?   -0.9   0.0      0.45   1.6e+03      95     103 ..     326     342 ..     267     346 .. 0.57

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.56
     DUF5074  46 ptslcasttenaLYfiggsswfsgkkiykydidtet..lseelitlpeeegksfYGagi 102
                 pt+ +++t++ ++ +   +  ++ ++ yk+d +      ++++++l + e k +Y   +
  EFC37636.1  52 PTATTSTTQSSVFDVLPSDCQWNMNSQYKHDRTMMFvtGKNDYLQLVAGE-KVIYDFTC 109
                 44444444444444444456777777777754433211445555555544.26665555 PP

  == domain 2  score: 19.1 bits;  conditional E-value: 2.7e-07
     DUF5074   2 vqskDGnvWaasgtkLvk..inpktle.vktvelpelsiesswyawtptslcasttenaLYfiggs 64 
                 ++  DG++W++ ++++ +  i+   l+  ++ve ++ s+ s+  +  +  lc s  +n+LY +g++
  EFC37636.1 187 ILNSDGSIWVTGDNSFHQlgIEVDHLKcFTKVEFQQDSPISHISTSYSHTLCYSERDNILYSMGTT 252
                 5678*******9999876226778899999******66666666666669*************998 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.45
     DUF5074  95 k........sfYGagir 103
                 +        +fYG g+ 
  EFC37636.1 326 HlflktisnQFYGLGMN 342
                 23333333378998886 PP

>> SH3_1  SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   6.6e-05      0.24       1      27 [.     102     128 ..     102     131 .. 0.90
   2 ?   -2.9   0.0       1.5   5.3e+03      24      37 ..     187     200 ..     186     203 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 6.6e-05
                 EESSSBEXSSTTBXEBSTTEEEEEEEE CS
       SH3_1   1 iAlYDYeaeesdELsfkkGDviivlek 27 
                 +++YD++ + ++ L f  +Dvi++ + 
  EFC37636.1 102 KVIYDFTCHLDQQLKFSLDDVIHIANG 128
                 689********************9875 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.5
                 EEEECSSSEEEEEE CS
       SH3_1  24 vleksedgWwkgrl 37 
                 +l+ + + W++g +
  EFC37636.1 187 ILNSDGSIWVTGDN 200
                 78888889*99987 PP

>> Reg_prop  Two component regulator propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.8   6.6e+03       4      16 ..     127     139 ..     124     140 .. 0.77
   2 ?    7.3   0.2    0.0019         7       6      24 .]     182     200 ..     178     200 .. 0.86
   3 ?    2.5   0.1      0.07   2.5e+02       6      23 ..     377     394 ..     372     395 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.8
                 SSCEEEEEE-TTS CS
    Reg_prop   4 snnvtaileDsdG 16 
                 +++ ++i+ +sdG
  EFC37636.1 127 NGDNHSIFLTSDG 139
                 5566899999999 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0019
                 CEEEEEE-TTSCEEEEESS CS
    Reg_prop   6 nvtaileDsdGrlWvGteg 24 
                 ++++i   sdG +Wv +++
  EFC37636.1 182 SFHSIILNSDGSIWVTGDN 200
                 7889999********9875 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.07
                 CEEEEEE-TTSCEEEEES CS
    Reg_prop   6 nvtaileDsdGrlWvGte 23 
                 ++++ l +s G+++v+++
  EFC37636.1 377 SYHTALTTSSGNIYVCGW 394
                 667777889******997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       542  (0.0302304); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 3040.63
//
Query:       EFC37637.1  [L=704]
Description: amidohydrolase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      3e-84  284.2   0.0    3.6e-84  283.9   0.0    1.1  1  Amidohydro_3  Amidohydrolase family
    2.4e-16   60.0   0.1    1.2e-09   38.0   0.1    3.3  3  Amidohydro_1  Amidohydrolase family


Domain annotation for each model (and alignments):
>> Amidohydro_3  Amidohydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  283.9   0.0     4e-88   3.6e-84      10     473 .]     166     690 ..     164     690 .. 0.91

  Alignments for each domain:
  == domain 1  score: 283.9 bits;  conditional E-value: 4e-88
  Amidohydro_3  10 vlPGFvDsHtHlagggvnlrllrlpdarvtslegvltavrdqagtt..pkgrwivgeGwdeaqfaeer...fpyalaeldevledapvllaaldtHa 101
                    +PGF+DsH+H++ gg  + +++l++  ++s ++ + avr+  ++   ++g+wi g  w+e+ +  e+    p  ++++d   + +pv+l+++d+H+
    EFC37637.1 166 IVPGFIDSHAHVILGGKSMLGVQLRN--AKSKDEFIGAVRKFIEERsvKAGEWITGAEWSETEWNIEGgtkLP-NKNWIDSFTSSNPVYLSRMDGHS 259
                   68**************9999999999..99999999999999998889****************865422277.9********************** PP

  Amidohydro_3 102 avrnsaaldlagiteatpdpaggeilrdangegatgllregafhlvldlaplareaeaaavaaalaalasyGitsv..eagggnvsslddleplfel 196
                    ++ns+a++la+it++t+   gg +  d  + ++tg+lr++a +++ + +  ++ ++++a++ a+ ++ ++Gitsv  ++   n  s d+++++ +l
    EFC37637.1 260 CLVNSKAMELANITKHTQIT-GGSVDLDPITGEPTGILRDRALDIIQKII--PPTDNEQAAKLAMDEILRNGITSVhdMGSVFNLASWDQVKTFTKL 353
                   *******************9.777777777777********877777766..44444555579********************************** PP

  Amidohydro_3 197 taeeklplrvi......ikelldaaerlglpls........................pgseeltigavklfadgvlgsrtalltepyf.....tgwp 258
                   +++++l +r+       +++ l++  + +   +                         g+e+++iga+k f dg+lgs+ta++ ep+      tg  
    EFC37637.1 354 HEKKQLKVRIYasveleTHQKLKKYIKNQYSKPksshvilndefdysccwteksggrAGDEWFKIGALKEFMDGSLGSKTAYMFEPFEgtennTGLL 450
                   ***********77766655555555555555448999999999999999999999*******************************99****99999 PP

  Amidohydro_3 259 dfedealaelvaaadergldvaihaigdaavddvldafeaa..aekngnqdrr.rlehaegvtesqiervaalqvaagvqpvfnfedelldsrlgpe 352
                    ++ e++ ++v++ad++  +v +haigd+a++ +ld++e++    +  ++drr r+eha+ ++e++ier+++ +++a++qp++  +d l+++++  e
    EFC37637.1 451 VVDPEVFYQRVKEADANHHQVIVHAIGDKAISILLDTYERVinESNDKTRDRRfRVEHAQQIREEDIERFKKNNIIASMQPIHLKDDALYAESIIRE 547
                   999***************************************66666677777******************************99************ PP

  Amidohydro_3 353 rargstpvkellnagvkvalgsDapvgpfdpwprigaavmrktrrgg................evlrpdeelsleealalyTrgpAkalgledrkGt 433
                   r++++++v+  ln+gvkvalg+D+ v+p+d +  i+aav+rk+   +                + + p+e++s+ee l +yT+++A+a + e++ Gt
    EFC37637.1 548 RQKQLYNVRKFLNKGVKVALGTDWFVAPLDILDNIHAAVTRKPCL-SplhverrneaknpkncKPFLPEEKISIEETLIAYTQNSAYAGFTEHEVGT 643
                   ******************************************974.259999999******999999****************************** PP

  Amidohydro_3 434 LevGadADlvvldadpldvdppelaear........vrltvvdGrvvy 473
                   L++G+ +D+++l++++l++d+++  +a+        + +t+v+G+v y
    EFC37637.1 644 LKKGYLGDITILSRNILELDETD-ESALdsitretkILMTIVGGKVMY 690
                   ********************874.44446999*************987 PP

>> Amidohydro_1  Amidohydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0   0.00023       2.1       2      13 ..     166     177 ..     165     207 .. 0.85
   2 !   10.6   0.0   2.9e-05      0.26      27     105 ..     304     379 ..     275     402 .. 0.68
   3 !   38.0   0.1   1.3e-13   1.2e-09     131     343 ..     454     688 ..     446     689 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00023
                   EEE-EEEEEEEC CS
  Amidohydro_1   2 vlPGlIDaHvHl 13 
                   ++PG+ID+H H+
    EFC37637.1 166 IVPGFIDSHAHV 177
                   89*********8 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 2.9e-05
                   H...STTHHHHHHHHHHHHHHHHTTEEEEEEEEHSSTH....HHHHHHHHHHTSSSEEEEEEESSEGGSGCCCSHHHHHHHHHHHH CS
  Amidohydro_1  27 l...vppetaaealesgiktalksGtttvadmgattst....giealleaaeelplglrilggkvsldrgsaetskasreklkaga 105
                   +   +pp + ++a++ ++ + l++G+t+v dmg +        ++   +  e+  l++ri+++          +++++ +klk+++
    EFC37637.1 304 IqkiIPPTDNEQAAKLAMDEILRNGITSVHDMGSVFNLaswdQVKTFTKLHEKKQLKVRIYAS----------VELETHQKLKKYI 379
                   35559****************************975446676555555555554457777755..........3344555555554 PP

  == domain 3  score: 38.0 bits;  conditional E-value: 1.3e-13
                   HHHHHHHHHHHHHHTTEEEEEETSSCHHHHHHHHHHTTTEEEETTTTSTCCHHTTTHCCEEEHCTCEEEHHHHHHHHHHHHHHCEE..........H CS
  Amidohydro_1 131 deelkealkeakkrdlpvaiHaletkgevedaeaafgetiehgthlevaeslglldeiklilahgvhltpteaellkerlkeagva..........h 217
                   +e  ++ +kea++   +v +Ha ++k++    ++ +  +++ ++  + ++        ++ ++h   +  +++e+ k++    ++           +
    EFC37637.1 454 PEVFYQRVKEADANHHQVIVHAIGDKAIS-ILLDTYE-RVINESNDKTRDR-------RFRVEHAQQIREEDIERFKKN----NIIasmqpihlkdD 537
                   677888899*************9988887.8888888.5555566666555.......9999*******9988886666....44446888844443 PP

                   HHHHHHH.......SEHHHHHHHHHHHHTSCEEEEEECT............TSSCCGGHHHH..........HHHHHHHHHHCCTT..TTHCHCHHH CS
  Amidohydro_1 218 cpfsnsi.......lrsgrealrkaldeGvkvglgtDga............asgnslnllee..........lrlalklqrgllye..deegglslk 283
                        ++        ++++ ++rk l++Gvkv+lgtD              a                    +    +  ++++ +   +e ++s++
    EFC37637.1 538 ----ALYaesiireRQKQLYNVRKFLNKGVKVALGTDWFvapldildnihaA---------VtrkpclsplhVERRNEAKNPKNCKpfLPEEKISIE 621
                   ....4445555788999********************335677664444431.........03345554555444444444444446678999**** PP

                   HHHHHHTHHHHHHTT-TTTSSSS-TTSB--EEEECCCT.......CGGGTTTCTSEEEEEEEETTEE CS
  Amidohydro_1 284 ealrmaTingAkalglddkvGsievGkdADlvvvdldi.......laafvglkkdgnvkkvivkGkl 343
                   e l ++T+n A a   +++vG++++G+  D++++  +i        +a+  +++  ++ ++iv+Gk+
    EFC37637.1 622 ETLIAYTQNSAYAGFTEHEVGTLKKGYLGDITILSRNIleldetdESALDSITRETKILMTIVGGKV 688
                   **********************************88556778899********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (704 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1048  (0.0584528); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.52
# Mc/sec: 4049.38
//
Query:       EFC37638.1  [L=519]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0024   17.7   0.0     0.0049   16.7   0.0    1.5  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.011   16.4   0.6      0.011   16.4   0.6    3.1  3  FYDLN_acid  Protein of unknown function (FYDLN_acid)
       0.66   10.0   9.1      0.056   13.4   2.9    2.1  2  Rota_NS26   Rotavirus NS26
       0.89    9.2   8.2        5.2    6.7   0.6    3.2  3  FAM176      FAM176 family


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   1.1e-06    0.0049       8      38 ..      53      84 ..      51      91 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.1e-06
  F-box-like  8 iLlqIFsyLppsdLlr.lalVCrrWrrvaldt 38
                +L+ I s+ ++ dL+r  alVCr+W++++l++
  EFC37638.1 53 VLMVIGSFAETIDLVRsMALVCRDWNQAVLND 84
                677777888889****77*********99876 PP

>> FYDLN_acid  Protein of unknown function (FYDLN_acid)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.5      0.27   1.2e+03      59      88 ..      17      34 ..       1      52 [. 0.37
   2 ?    2.2   1.0     0.063   2.8e+02      81      98 ..     124     141 ..     110     154 .. 0.56
   3 ?   16.4   0.6   2.5e-06     0.011      26      94 ..     187     257 ..     181     264 .. 0.65

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.27
  FYDLN_acid 59 eeeedeedeeeeedvsdedadeeeeedddd 88
                 e ++++++++++dv d            d
  EFC37638.1 17 LEPQSKKTKKSNDDVGD------------D 34
                11111111111222211............1 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.063
  FYDLN_acid  81 eeeedddddvdleedddd 98 
                 e+e+d+d+d+d ++ dd 
  EFC37638.1 124 EKENDEDEDDDYSNCDDR 141
                 111222222233444443 PP

  == domain 3  score: 16.4 bits;  conditional E-value: 2.5e-06
  FYDLN_acid  26 Pivcpkcgeefepeev..lksraaaaeaeeakkkkeeeedeedeeeeedvsdedadeeeeedddddvdlee 94 
                 Pi cpk  +e e+     + ++++ ++++++kk++++++  +++ +eed  ++d+ +   ++dddd+d e+
  EFC37638.1 187 PIQCPKLITENEIVIPlnKGTKKKITKKKKSKKNTKKKAPPKKDSDEEDYLKKDVIHRVLSEDDDDSDFEK 257
                 99***976666665552244455555555555666666666666666666667777666668888777654 PP

>> Rota_NS26  Rotavirus NS26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.4      0.25   1.1e+03     149     183 ..     104     138 ..      94     146 .. 0.65
   2 ?   13.4   2.9   1.2e-05     0.056     129     190 ..     207     265 ..     192     284 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.25
   Rota_NS26 149 sieinsdleefnpiqkkvkkeavsevleDeDaddc 183
                 +i++n  ++   p   k kke  ++  eD+D  +c
  EFC37638.1 104 KINYNLSVDLMAPFAIKAKKEKENDEDEDDDYSNC 138
                 56666666777777777777776664444444443 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 1.2e-05
   Rota_NS26 129 kekeksktenkskknvsayasieinsdleefnpiqkkvkkeavsevleDeDaddckCknCkY 190
                   k+k ++++kskkn ++ a  + +sd+e++  ++k v +  +se  +D+D ++ +  n  Y
  EFC37638.1 207 T-KKKITKKKKSKKNTKKKAPPKKDSDEEDY--LKKDVIHRVLSEDDDDSDFEKKISSNYYY 265
                 2.334445579********************..66666666666666666767666666655 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.016        73      50      93 ..       6      49 ..       1      75 [. 0.70
   2 ?    2.6   0.3     0.021        96      67      87 ..     122     142 ..     111     163 .. 0.59
   3 ?    6.7   0.6    0.0012       5.2      52     104 ..     208     264 ..     192     286 .. 0.49

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.016
      FAM176 50 dlerlkkkkkklkeesekasededeeeeeeeedsseseaeeels 93
                +  ++k++ k+l+++s+k+++++d+  ++e  + ++se+++el 
  EFC37638.1  6 NSAPPKNSSKHLEPQSKKTKKSNDDVGDDEMMMIKRSETSTELF 49
                44567778888999988887777777777777777777666664 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.021
      FAM176  67 kasededeeeeeeeedssese 87 
                 k+++++de+e+++ ++  ++e
  EFC37638.1 122 KKEKENDEDEDDDYSNCDDRE 142
                 223333344444433333333 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0012
      FAM176  52 erlkkkkkklkeeseka...sededeeeeeeeedssesea.eeelsefertlsvnvf 104
                 +++ +kkkk k++++k+   ++d+dee+  +++  ++  + +++ s+fe+++s n +
  EFC37638.1 208 KKKITKKKKSKKNTKKKappKKDSDEEDYLKKDVIHRVLSeDDDDSDFEKKISSNYY 264
                 433333333333333333445555555444444433333202333666666655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (519 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1391  (0.0775838); expected 358.6 (0.02)
Passed bias filter:                      609  (0.0339673); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.49
# Mc/sec: 3169.03
//
Query:       EFC37639.1  [L=1429]
Description: cation translocating P-type ATPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-31  108.1   0.0    3.6e-31  108.1   0.0    3.6  4  E1-E2_ATPase   E1-E2 ATPase
    1.4e-11   45.1   0.0    0.00026   21.3   0.0    2.8  2  Hydrolase      haloacid dehalogenase-like hydrolase
      1e-05   25.5   0.0    3.2e-05   23.9   0.0    1.8  1  Cation_ATPase  Cation transport ATPase (P-type)
    0.00035   20.7   4.0    0.00035   20.7   4.0    3.5  3  P5-ATPase      P5-type ATPase cation transporter


Domain annotation for each model (and alignments):
>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.3      0.24   1.1e+03     106     140 ..     427     461 ..     420     479 .. 0.75
   2 !  108.1   0.0   7.9e-35   3.6e-31      10     180 ..     521     716 ..     514     717 .. 0.97
   3 ?   -0.9   0.9      0.22   9.8e+02     117     166 ..    1156    1206 ..    1147    1217 .. 0.66
   4 ?   -3.1   2.4       1.1   4.7e+03     110     136 ..    1302    1328 ..    1271    1374 .. 0.53

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.24
                   ----HHHHHHHHHHHHHHHHHHHHHHHHHHS-STT CS
  E1-E2_ATPase 106 skktplqkkldklgkvlvpvvlliallvflialll 140
                   + k+ +q  ld++   + ++ ++i++l fl ++++
    EFC37639.1 427 PMKSGVQILLDEILHPFYLFQVFILVLWFLEQYYT 461
                   56888999999999999999999999988877653 PP

  == domain 2  score: 108.1 bits;  conditional E-value: 7.9e-35
                   E-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-SEEE-TTTS---S-EE-...............G-TTEE-TT-EEEE..........-EE CS
  E1-E2_ATPase  10 irdgteeeidakelvpGDivllkagdrvpaDgrivegsaevdesaLTGEslpvek...............ekgdmvfsGtvvvs..........gea 81 
                    r+++eee+d+ +l pGDi+++  g++ p+D++++ g+  v+es LTG+s pv+k               e+++++fsGt+v+            ++
    EFC37639.1 521 KRNEEEEEMDSLDLFPGDIIEITDGMTLPCDVILLGGQVIVNESKLTGDSIPVKKrplpyddaklyypsrENNHTIFSGTQVLTakpspnslfaNKC 617
                   399******************************************************************99************************** PP

                   EEEEEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHHHS-TTHHHHHHHHHHHHHHHH CS
  E1-E2_ATPase  82 kavVtatgedtelgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgkslaeallralallvaaiPcaLplavplalalgarrl 178
                    ++V +tg +t  gk+  ++  +k +++++ +   k+  vlv+++++ ++ +++ ++ lg ++ + +l++l+++++++P+ Lpla+++++++ +rrl
    EFC37639.1 618 FGIVSQTGFNTLKGKLLLSILFPKTAEFNVYRDSLKFLIVLVVTGFIGIIGTAANLFKLGAPAGNVFLHILDIITISVPPTLPLAMTTTITFTMRRL 714
                   *****************************************************99999999999********************************9 PP

                   HH CS
  E1-E2_ATPase 179 ak 180
                    k
    EFC37639.1 715 GK 716
                   87 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.22
                    HHHHHHHHHHHHHHHHHHHS-STTTSSTT.HHHHHHHHHHHHHS-TTHHHH CS
  E1-E2_ATPase  117 klgkvlvpvvlliallvflialllgksla.eallralallvaaiPcaLpla 166 
                     +++++ +++l  ++ ++ i +ll ++++   + + +  l++++P  L ++
    EFC37639.1 1156 TFFQIFKFIALYSIVQIMTIVVLLSRNCNfVDFQFLFIDLIVVMPTTLLMT 1206
                    566676666666666666666666777766666666666677778888554 PP

  == domain 4  score: -3.1 bits;  conditional E-value: 1.1
                    HHHHHHHHHHHHHHHHHHHHHHHHHHS CS
  E1-E2_ATPase  110 plqkkldklgkvlvpvvlliallvfli 136 
                    +l  + ++++ +l+++++ +a + +l+
    EFC37639.1 1302 KLPIITNNFTFTLFIIIIYLATAYLLF 1328
                    444444444444333332222222222 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.0   1.2e-07   0.00054       1     154 [.     733     981 ..     733    1004 .. 0.74
   2 !   21.3   0.0   5.8e-08   0.00026     171     209 ..    1079    1117 ..    1057    1118 .. 0.86

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 1.2e-07
                 SSEEEEESBTTTBCHHHHHHHHHHHH.........................................CHHHHHHHHHH.................HHCH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx.........................................xxxxxxxxxxx.................xxxx RF
   Hydrolase   1 iktvvfDkdGTLttgepsvedvivsa.........................................alalaaaletg.................sehp 41 
                 +k  vfDk++T+t+ e  v+ +++s+                                                                     se  
  EFC37639.1 733 VKIAVFDKTNTITENEIDVHGIFPSVeglfhpyvkgtnisklfasnstlvqclaccnnlsrvgttfiG---------DpldsklfqtskwsmqdiSESA 822
                 6899************8888888888777777788888877777777777777776644444444441.........0333333333445455554444 PP

                 HHHHHHHHHHHH..............HHHHHHHHHETTTE..................HHHHTHHHHHHHH....HCHHHHHHHHHHHHHHCHHHHHH. CS
                 xxxxxxxxxxxx..............xxxxxxxxxxxxxx..................xxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxx. RF
   Hydrolase  42 igkalvaaakar..............sgaltgfatfigrg..................ayaigkpewltal....dippdlgaaigsaqsqgrtvall. 103
                 +g  +  +  +               +                               a+a+g+ e +++      ipp++ +    + ++g  v+ l 
  EFC37639.1 823 YGHTIFFESTDQkveksysklnvfdfK------------SsvqrmsvviknnatgnlhAFAKGSAESVKSIskpsSIPPNYSDMLKCYAQKGYRVMALa 909
                 444442222222244455544444442............0333334555555888899***************************************** PP

                 .......................TTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHH CS
                 .......................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 104 .......................qaralavftiadplkvkpeaaeavasLkaagievvlltgdnpetaeraanq 154
                                        + +  +++ ++++  vk+++ + +++L + +i+ ++++gdn  t   +a++
  EFC37639.1 910 sktlpsnltlseletlpreyvesEMEFIGLLLVENK--VKKGTSKSIKTLLDCNIKCIICSGDNAYTSINVARK 981
                 *********************999999999999999..**************************9777666665 PP

  == domain 2  score: 21.3 bits;  conditional E-value: 5.8e-08
                  STTTSHHHHHHHHHHHTSTGGGEEEEESSHHHHHHHHHT CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase  171 vakpspegkvaaireLqgkpeevamVGDgvnDaaalaaA 209 
                   a  sp++k+ ++ eLq  + +v m+GDg+nD+ al+ A
  EFC37639.1 1079 YARFSPNHKKTLVTELQKMGYDVGMIGDGANDLGALRSA 1117
                  67789************99999**************998 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.0   7.2e-09   3.2e-05      36      84 ..     830     878 ..     778     883 .. 0.78

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 7.2e-09
  Cation_ATPase  36 gldteelreetkkvqeipFnssrKrmsvvlklepekkvrlyvKGApeii 84 
                    +   +++++++ k++++ F ss  rmsvv+k++ ++++ ++ KG++e++
     EFC37639.1 830 ESTDQKVEKSYSKLNVFDFKSSVQRMSVVIKNNATGNLHAFAKGSAESV 878
                    5677899****************************************98 PP

>> P5-ATPase  P5-type ATPase cation transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.5      0.67     3e+03      66     101 ..      33      69 ..      23     123 .. 0.63
   2 !   20.7   4.0   7.8e-08   0.00035       6      77 ..     274     351 ..     270     380 .. 0.86
   3 ?   -3.7   0.1       2.7   1.2e+04      65      89 ..     811     833 ..     809     852 .. 0.51

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.67
   P5-ATPase  66 elsvkkvrkleyer.plstvfsseqeegeekeieske 101
                 +l+ ++ ++  +++  lst+ ++e  +++e+++++ +
  EFC37639.1  33 NLFRVDSESAMMNEsTLSTIDEDERFHNDEEQNNNMN 69 
                 4444444444455524777775555544444443332 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 7.8e-08
   P5-ATPase   6 eiaGyrtsrwrlalyilgciltlGlllLlfrWlPewrvkltgkpc.....pLkeadvvlie.defgelsvkkvrkley 77 
                  i G r++ +  +l++l+++ + G ll+ +rWl  ++  +t + +     ++++a+ vli+ +e ++++++k++k  +
  EFC37639.1 274 SIKGLRHQFYLEVLFWLCVVASAGSLLVCCRWLKWLKSYMTYSYSsnnghSFADASKVLIKaKETNQWTIVKIKKGFV 351
                 58899*****************************9999999876622233688********99999999999998654 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 2.7
   P5-ATPase  65 gelsvkkvrkleyerplstvf.sseq 89 
                 +++s++++++  y++   t+f +s++
  EFC37639.1 811 SKWSMQDISESAYGH---TIFfESTD 833
                 567777777777777...44411111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1429 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1021  (0.0569468); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.73u 0.28s 00:00:01.01 Elapsed: 00:00:00.46
# Mc/sec: 9339.00
//
Query:       EFC37640.1  [L=543]
Description: regulator of G protein signaling domain [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.1e-14   51.9  24.1    5.1e-14   51.9  24.1    2.2  2  Ifi-6-16  Interferon-induced 6-16 family
    5.7e-06   26.6   0.1      1e-05   25.8   0.1    1.4  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> Ifi-6-16  Interferon-induced 6-16 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.9  24.1   5.7e-18   5.1e-14       3      64 ..       7      68 ..       5      84 .. 0.82
   2 ?   -0.8   0.1      0.16   1.4e+03      53      66 ..     337     350 ..     332     359 .. 0.73

  Alignments for each domain:
  == domain 1  score: 51.9 bits;  conditional E-value: 5.7e-18
    Ifi-6-16  3 gvvavvaaPvvlsalGFtaaGiaagSlAAkmmSaaAianGGgVaaGslvAvlQSaGaaGlsa 64
                g+++ +    ++s  GFt+aGiaagS+AA++mS++Aia+GGgVaaGs+v+++Q+a+a+G+  
  EFC37640.1  7 GTLTYLGFTQAVSWFGFTKAGIAAGSCAAAWMSSTAIASGGGVAAGSAVSTMQAAAATGAIG 68
                5666777778899*******************************************998533 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.16
    Ifi-6-16  53 vlQSaGaaGlsaaa 66 
                 v+QS+G+ ++ +a+
  EFC37640.1 337 VIQSIGMGAFIVAG 350
                 78999998776665 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.1   1.2e-09     1e-05       5      71 ..     419     485 ..     416     540 .. 0.77

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 1.2e-09
                 HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HH CS
         RGS   5 lledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkk 71 
                 +l++ +  +++ +F +++++ e +  w++++++k+ ++ +++k+ ak I+++y++ +sp eln+ + 
  EFC37640.1 419 VLKNRKTFNILLDFARRSYCPEPVLCWQDIQRYKSPQQVKNRKEIAKFIIDNYISLNSPLELNMASI 485
                 78999999****************************99999*************9999999988643 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (543 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       810  (0.0451782); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 3738.00
//
Query:       EFC37641.1  [L=1082]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0013   19.0   0.3      0.016   15.5   0.0    3.1  2  PRANC         PRANC domain
  ------ inclusion threshold ------
      0.058   12.7   0.0       0.11   11.8   0.0    1.4  1  aGPT-Pplase3  Alpha-glutamyl/putrescinyl thymine pyrophosphor


Domain annotation for each model (and alignments):
>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   1.8e-06     0.016      68      93 ..      83     109 ..      55     113 .. 0.78
   2 ?   -2.5   0.1      0.77   6.9e+03      16      39 ..     505     528 ..     495     546 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.8e-06
       PRANC  68 k.kslWnlLPiEIkykIleyLndkdLk 93 
                 + ++l + LP+EI+y+I+++++dk L 
  EFC37641.1  83 RfRNLFSKLPLEIHYQIMSFMDDKTLM 109
                 236999******************985 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.77
       PRANC  16 inllvrlinkkklkklkslkiYgk 39 
                 +++  +++n+ k + l+s+ +Y+ 
  EFC37641.1 505 SQVIEKFLNRLKSSHLQSIDFYQH 528
                 357777788888888888888875 PP

>> aGPT-Pplase3  Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   1.3e-05      0.11     118     200 ..     487     567 ..     477     581 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.3e-05
  aGPT-Pplase3 118 fgnhrkyeslkpakkrgtgkviesYvewiaeagshealfaqlvrqagndpeaiFdelykslekvkrfgrlgkfdyltllgklg 200
                    gn  k  s   ++ ++ ++vie++++ +++  sh + ++  +++a  + ++ F++l++ l+k + ++ ++ f  lt l+ ++
    EFC37641.1 487 VGNTSKLASKLFHSLSNESQVIEKFLNRLKS--SHLQSIDFYQHKASTESDTLFQQLLQYLKKQTCSNPIVLFPMLTRLSTVD 567
                   6899999999999999999**********99..*******************************************9999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1082 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1007  (0.056166); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.92u 0.30s 00:00:01.22 Elapsed: 00:00:00.51
# Mc/sec: 6377.90
//
Query:       EFC37642.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.6e-16   59.8   0.0    4.1e-16   59.1   0.0    1.3  1  SHS2_Rpb7-N  SHS2 domain found in N terminus of Rpb7p/Rpc25p/
    2.2e-07   31.1   0.0    4.6e-07   30.1   0.0    1.5  1  S1           S1 RNA binding domain


Domain annotation for each model (and alignments):
>> SHS2_Rpb7-N  SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.1   0.0   4.5e-20   4.1e-16       2      70 .]       9      77 ..       8      77 .. 0.98

  Alignments for each domain:
  == domain 1  score: 59.1 bits;  conditional E-value: 4.5e-20
                 EEEEE-GGGTTSTHHHHHHHHHHHHHTTBEETTTEEEEEEEEEEEECCEEE-TTTSSEEEEEEEEEEEE CS
  SHS2_Rpb7-N  2 dtvrlePsylgstledallerllekyegkvvpslGvivavldiaeysegkvlggsGsvyvrVtfralvF 70
                 +++rl+P ++g++l++ l++rl++++eg++    G+iv+v++i+++++gk+ ++sG + + + ++a+vF
   EFC37642.1  9 KNIRLHPKFFGPDLTRTLRARLQNDVEGQCTGRDGYIVSVTEITKIGQGKIGESSGYATFPINYKAIVF 77
                 589*****************************************************************9 PP

>> S1  S1 RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.0   5.1e-11   4.6e-07       1      46 [.      78     121 ..      78     127 .. 0.90

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 5.1e-11
                 HSTTTCEEEEEEEEEETTEEEEEETTTEEEEEEGGGSSSSCEESCH CS
          S1   1 kpekgevveGeVtsvtkgGafVelgngvegfvpaselsrdarvedp 46 
                 kp+kgev +++V++vt++G+f  +g +  +fv+ + +++d +++d+
  EFC37642.1  78 KPFKGEVCDAVVYKVTPVGFFASVG-PLNVFVSSHAVPDD-MKYDG 121
                 79***********************.**************.55554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       329  (0.0183502); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.29s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1099.26
//
Query:       EFC37643.1  [L=651]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.6e-26   92.2   0.0      2e-17   63.9   0.0    2.3  2  ADP_ribosyl_GH  ADP-ribosylglycohydrolase
  ------ inclusion threshold ------
      0.048   12.7   0.8        0.1   11.7   0.8    1.4  1  B277            Domain of unknown function


Domain annotation for each model (and alignments):
>> ADP_ribosyl_GH  ADP-ribosylglycohydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.9   0.0   2.2e-21     2e-17       1     138 [.      91     284 ..      91     293 .. 0.92
   2 !   26.0   0.0   7.9e-10   7.1e-06     148     287 ..     344     555 ..     337     558 .. 0.74

  Alignments for each domain:
  == domain 1  score: 63.9 bits;  conditional E-value: 2.2e-21
                     HHHHHHHHHHHHHGGGTT--HHHHHHHTSS--S.......................................-----STTTTTS-TT---HHHHH CS
  ADP_ribosyl_GH   1 GallGaavGDAlGlpvefwsydeirrrygelge.......................................tpdktgfghfglkpgewtddtqm 56 
                     G+++G++ GD +G+p e+w  +eir+ yg+++                                        +++++ f ++ +++g ++ddtq+
      EFC37643.1  91 GSIWGQVYGDVAGCPIEGWKSGEIRKFYGDKEFllfdfglivkkgfpskelmdskdfshlqnakkvvgvkrkESGTELFLRHIRPVGIHSDDTQQ 185
                     89*****************************99*************************************9999999999999************ PP

                     HHHHHHTEET......TEE-HHHHHHHHHH.HHT...................T--SS--HHHHHHHHHTTT.T-...-S-B...---BTTTGGG CS
  ADP_ribosyl_GH  57 allllesllea.....ggldpedlarrflaeWlee.p..............gdteprgignttrealrnlks.gepppeaganangsagngalmR 130
                      ++l++s+le      ++ ++++++   +++Wl e +              ++++ r +g++t++al+++ + +++  e+g++    +g+g+ mR
      EFC37643.1 186 GFALINSILEFvkyskDHENITEFLSY-WRKWLYEgFtkgdcklgdelvakNSQAFRQFGSNTSRALKKIVNqNKSCYESGSK---TTGIGGMMR 276
                     **********98888777788999988.555999988*********************************7746677777776...********* PP

                     -HHHHHHT CS
  ADP_ribosyl_GH 131 aaplglly 138
                     + + +  +
      EFC37643.1 277 CCVAPTCF 284
                     *9986555 PP

  == domain 2  score: 26.0 bits;  conditional E-value: 7.9e-10
                     HHHHHHHTTB--HHHHHHHHHHHHHHHHHHTT--STHHHHHH.............................HHHHTTT-HHHHHHHGGGGG---H CS
  ADP_ribosyl_GH 148 laeeaarlTHnhpeavagaaayaaliaaalrgksleealdaa...........................eeelavapaeeelaaalrkalalads 215
                     ++++++ +TH++ e+  +  a + +++  ++  + +e +d                             ++++ + +  e++ + ++ + ++ ++
      EFC37643.1 344 FSYAQCLTTHSTIESSSVTFASNVIAYKFIQDGNSQETIDWIldnlplivqkheklwlqrsycpelkkgDRVENQFQIYEPMNQSIHNVSNILEQ 438
                     67889999999999999999999999999999988888888889999999888888888888888888844444444444444444444444444 PP

                     HH..............................HHHHH--SSBHHHHHHHHHHHHHH.-SS........................HHHHHHHHHTS CS
  ADP_ribosyl_GH 216 dkd......................vdvdaeeavdelgsggyavealaaalyallhaadd........................feeallaavnl 264
                       +                      ++  +++a+++  ++g+++     +l a    +++                        +e +l   ++ 
      EFC37643.1 439 VFEfikenreselllkncrekiselAKSVKKKAMKANVNQGFCLLGGIHCLVASVM-PENpriilaahpskayhlklalpnipfPELLLYSIISN 532
                     44455555559999999988887776666777777777777776666666666666.4445666666677778888888888877888888999* PP

                     -SSHHHHHHHHHHHHHHHH-GGG CS
  ADP_ribosyl_GH 265 GgDtdttgaiaGallGalyGlea 287
                     G Dtdt++ai G +lGa++G+++
      EFC37643.1 533 GYDTDTVAAISGYMLGARFGASS 555
                     ********************987 PP

>> B277  Domain of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.8   1.1e-05       0.1       9      79 ..     404     475 ..     398     480 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.1e-05
        B277   9 afeeelrkaqsleelkqkyeeaqkqiad.gkvlkrlyk.vyekrqtelmlqqyrqikaelekrkkvkkkdkad 79 
                 ++  el+k + +e+  q ye  ++ i +  ++l +++  + e+r++el+l++ r+  +el k  k kk  ka+
  EFC37643.1 404 SYCPELKKGDRVENQFQIYEPMNQSIHNvSNILEQVFEfIKENRESELLLKNCREKISELAKSVK-KKAMKAN 475
                 56679****************9999987368999999746799*************9**988654.3334555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (651 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1636  (0.0912488); expected 358.6 (0.02)
Passed bias filter:                      699  (0.0389871); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.25s 00:00:00.89 Elapsed: 00:00:00.43
# Mc/sec: 4533.58
//
Query:       EFC37644.1  [L=606]
Description: alpha tubulin suppressor family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      2e-34  117.9   6.4    9.1e-07   29.4   0.0    7.7  7  RCC1            Regulator of chromosome condensation (RCC1) r
    1.1e-15   56.9  20.2     0.0002   21.0   1.1    6.2  7  RCC1_2          Regulator of chromosome condensation (RCC1) r
    3.4e-11   43.6   0.4    1.6e-10   41.4   0.1    2.3  2  PH              PH domain
    9.9e-05   22.5   0.0    0.00021   21.5   0.0    1.5  1  PH_8            Pleckstrin homology domain
    0.00056   20.3   2.9     0.0017   18.8   2.5    2.1  1  PH_11           Pleckstrin homology domain
  ------ inclusion threshold ------
      0.039   14.3   0.0      0.095   13.1   0.0    1.6  1  PH_2            Plant pleckstrin homology-like region


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0    0.0042        13      32      50 .]      22      40 ..      17      40 .. 0.87
   2 !   29.4   0.0   3.1e-10   9.1e-07       1      39 [.      43      86 ..      43      97 .. 0.67
   3 !   22.0   0.0   6.2e-08   0.00019       4      35 ..     103     134 ..     102     144 .. 0.87
   4 !   10.5   0.1   0.00025      0.74      30      50 .]     161     181 ..     158     181 .. 0.85
   5 !   14.0   0.0   1.9e-05     0.058       3      49 ..     186     249 ..     184     250 .. 0.67
   6 ?    4.3   0.9     0.022        65       1      12 [.     253     264 ..     253     298 .. 0.79
   7 !   25.9   0.0   3.7e-09   1.1e-05       5      50 .]     318     372 ..     316     372 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0042
                GTTS-EEEEEEETTEEEEE CS
        RCC1 32 lsgnrvvkvacGddhtval 50
                ls++++++++cG +++++l
  EFC37644.1 22 LSSKEIIQIVCGLNFCACL 40
                6778***********9986 PP

  == domain 2  score: 29.4 bits;  conditional E-value: 3.1e-10
                TTEEEEEE--GGGTTSSSS-.....--EEE..EEE-GGGTTS-EEE CS
        RCC1  1 dGrVysWGrndyGqLGlgtt.....esvlv..Ptkveglsgnrvvk 39
                +G++y+WG++ yGqLG+  +     e+  v  P k+ ++s  + + 
  EFC37644.1 43 NGDIYTWGNGMYGQLGHREQvvsayEEFKVprPIKIDNFS--NGIY 86
                69***************99976655444552255555555..5555 PP

  == domain 3  score: 22.0 bits;  conditional E-value: 6.2e-08
                 EEEEE--GGGTTSSSS---EEEEEE-GGGTTS CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkveglsgn 35 
                 +y+WG+n  G LG+g++++v  P++v g +gn
  EFC37644.1 103 LYTWGKNFCGMLGHGDEKDVFEPKRVIGVTGN 134
                 8*************************998887 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 0.00025
                 GGGTTS-EEEEEEETTEEEEE CS
        RCC1  30 eglsgnrvvkvacGddhtval 50 
                  +l++++v++v+cG++h +++
  EFC37644.1 161 DNLEKEEVIHVSCGQSHMACV 181
                 567778***********9885 PP

  == domain 5  score: 14.0 bits;  conditional E-value: 1.9e-05
                 EEEEEE--GGGTTSS..SS-.--EEEEEE-...........GGGTTS.......-EEEEEEETTEEEE CS
        RCC1   3 rVysWGrndyGqLGl..gtt.esvlvPtkv...........eglsgn.......rvvkvacGddhtva 49 
                 ++++WG+n  G LG+   t+ es  +P +v                n       ++++v c  + t+a
  EFC37644.1 186 EIFTWGNNFLGPLGRilDTKqESDFYPHLVdlvqvgdlvteD----NlkqsdevDFIQVECLKYNTIA 249
                 69*************75333466699*888444445555542....0334457788888887777766 PP

  == domain 6  score: 4.3 bits;  conditional E-value: 0.022
                 TTEEEEEE--GG CS
        RCC1   1 dGrVysWGrndy 12 
                 dGr++s+G++ y
  EFC37644.1 253 DGRLFSCGKGGY 264
                 9********987 PP

  == domain 7  score: 25.9 bits;  conditional E-value: 3.7e-09
                 EEEE--GGGTTSSSS---E.........EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   5 ysWGrndyGqLGlgttesv.........lvPtkveglsgnrvvkvacGddhtval 50 
                 y WG+n+++ LG+++ +++         l+P+k ++++ ++   ++cG  ht+++
  EFC37644.1 318 YIWGNNEDNKLGIPNLNDEslsideaslLHPKKFPFSTPRDCYMICCGETHTAVI 372
                 89***********88855545666666688********99************997 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   1.1   6.8e-08    0.0002       1      30 []      27      56 ..      27      56 .. 0.95
   2 !    8.9   0.1   0.00043       1.3      14      29 ..      97     112 ..      89     112 .. 0.91
   3 !   21.0   0.6   6.9e-08   0.00021       1      29 [.     168     196 ..     168     196 .. 0.94
   4 !   13.3   0.0   1.8e-05     0.054       9      26 ..     245     262 ..     244     266 .. 0.89
   5 ?    2.3   0.0     0.053   1.6e+02      11      28 ..     302     325 ..     288     326 .. 0.73
   6 ?   -1.3   0.0      0.69     2e+03       4      14 ..     362     372 ..     361     374 .. 0.85
   7 ?   -2.9   0.0       2.2   6.5e+03      15      21 ..     576     582 ..     575     582 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 6.8e-08
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30
                ++++ +G ++   L+++G++++WG+  +GQ
  EFC37644.1 27 IIQIVCGLNFCACLSRNGDIYTWGNGMYGQ 56
                79***********************98888 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00043
      RCC1_2  14 LtedGeVlcWGsNsdG 29 
                 +t++ ++++WG N +G
  EFC37644.1  97 ITRERHLYTWGKNFCG 112
                 899999*********9 PP

  == domain 3  score: 21.0 bits;  conditional E-value: 6.9e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 V++vs+G +H   +t+ +e+++WG+N  G
  EFC37644.1 168 VIHVSCGQSHMACVTAKNEIFTWGNNFLG 196
                 89************************765 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 1.8e-05
      RCC1_2   9 yHscaLtedGeVlcWGsN 26 
                 y ++aLt+dG+++++G  
  EFC37644.1 245 YNTIALTSDGRLFSCGKG 262
                 789*************76 PP

  == domain 5  score: 2.3 bits;  conditional E-value: 0.053
      RCC1_2  11 scaLtedGe......VlcWGsNsd 28 
                 +++L +d++       + WG+N+d
  EFC37644.1 302 AIVLNSDDDsknredFYIWGNNED 325
                 566666666777777899****97 PP

  == domain 6  score: -1.3 bits;  conditional E-value: 0.69
      RCC1_2   4 vsaGdyHscaL 14 
                 +++G  H+ ++
  EFC37644.1 362 ICCGETHTAVI 372
                 799****9987 PP

  == domain 7  score: -2.9 bits;  conditional E-value: 2.2
      RCC1_2  15 tedGeVl 21 
                 t++G+V+
  EFC37644.1 576 TSNGRVY 582
                 89****8 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.3   3.9e+03      17      61 ..     355     401 ..     342     422 .. 0.65
   2 !   41.4   0.1   5.5e-14   1.6e-10       2     104 ..     512     603 ..     511     604 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.3
                 SEEEEEEEEETTE..EEEESSTTCTTESSEEEEEESTTEEEEEEEC..T CS
          PH  17 swkkrwfvLkdse..llyykndksekdkepkgsislsncevvevva..t 61 
                 + ++++++  ++    ++ k++  ++dk+p   + l++ e  e++   +
  EFC37644.1 355 TPRDCYMICCGEThtAVILKPH--SSDKNPNADLTLEKFERGETNPnvS 401
                 4555666666555566666666..7899999999999999888765652 PP

  == domain 2  score: 41.4 bits;  conditional E-value: 5.5e-14
                 EEEEEEEEETSSSSC.SEEEEEEEEETTEEEEESSTTCTTESSEEEEEESTTEEEEEEECTTSSSSTSEEEEEESTSSSTEEEEEEESSHHHHHHHHHH CS
          PH   2 vkeGwLlkkgsgkkk.swkkrwfvLkdsellyykndksekdkepkgsislsncevvevvatedpkrkfcfelriverngsrtyllqasseeerkeWika 99 
                 + +G+L+kkg++     w+krwf L ++ l+yy+++      + kgsi ++++ +        + ++  f + ++  ng r+y lqa se+e+k W + 
  EFC37644.1 512 ELHGYLQKKGEKGLVkLWRKRWFNLEGNYLCYYEKE----GGKSKGSICVDDVLDIL-----PGSTPLAFNVSTS--NG-RVYELQAGSEQELKYWKNG 598
                 579****999876558********************....***************98.....7999999999888..99.******************* PP

                 HHHHH CS
          PH 100 iqsai 104
                 i+s+i
  EFC37644.1 599 IRSLI 603
                 *9987 PP

>> PH_8  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.0   7.1e-08   0.00021       1      86 [.     515     600 ..     515     602 .. 0.78

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 7.1e-08
        PH_8   1 gillkkrrkkl.qgyakRfFvLdlksstlsYyrddnssalrgkiplsla.iisaneekreiiid.sGaevWeLkasnekdfqeWveale 86 
                 g l+kk  k l + ++kR+F L  +   l Yy+ +++++ +g+i ++    i   ++   +++  s ++v+eL+a +e++ + W++ + 
  EFC37644.1 515 GYLQKKGEKGLvKLWRKRWFNL--EGNYLCYYE-KEGGKSKGSICVDDVlDILPGSTPLAFNVStSNGRVYELQAGSEQELKYWKNGIR 600
                 67899998875378******99..888999*99.6688999****98653244445555667752678****************99875 PP

>> PH_11  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   2.5   5.7e-07    0.0017       2      36 ..     514     551 ..     513     564 .. 0.90

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 5.7e-07
       PH_11   2 kGylkkkgsk....aWkrrwfavlkdgvLeyYksekkkv 36 
                 +Gyl+kkg+k     W++rwf  l+   L yY++e+ k 
  EFC37644.1 514 HGYLQKKGEKglvkLWRKRWF-NLEGNYLCYYEKEGGKS 551
                 8***********999******.************99886 PP

>> PH_2  Plant pleckstrin homology-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   3.2e-05     0.095      69     102 ..     570     604 ..     546     606 .] 0.89

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.2e-05
        PH_2  69 yyfglkTaeg.lvefeckskaekkvWvegiknlLs 102
                   f ++T++g + e+++ s++e k W++gi++l+s
  EFC37644.1 570 LAFNVSTSNGrVYELQAGSEQELKYWKNGIRSLIS 604
                 789******9999*******************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (606 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1066  (0.0594567); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.83u 0.35s 00:00:01.18 Elapsed: 00:00:00.54
# Mc/sec: 3407.55
//
Query:       EFC37645.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.1e-78  261.8   0.0    6.9e-78  261.6   0.0    1.0  1  Pkinase         Protein kinase domain
    1.5e-48  165.4   0.0    1.7e-48  165.1   0.0    1.0  1  Pkinase_Tyr     Protein tyrosine kinase
    3.4e-06   26.6   0.1    6.8e-05   22.3   0.0    2.1  2  Kinase-like     Kinase-like
    6.5e-06   26.2   0.0      0.022   14.7   0.0    2.1  2  APH             Phosphotransferase enzyme family
    1.1e-05   24.6   0.1    4.7e-05   22.5   0.1    1.8  1  Haspin_kinase   Haspin like kinase domain
    1.5e-05   23.9   0.1    6.3e-05   21.9   0.0    1.7  2  Pkinase_fungal  Fungal protein kinase
    0.00014   21.5   0.1    0.00021   21.0   0.1    1.2  1  RIO1            RIO1 family
    0.00039   20.1   0.1     0.0042   16.7   0.0    2.1  2  FTA2            Kinetochore Sim4 complex subunit FTA2
     0.0043   16.6   0.2     0.0068   16.0   0.2    1.3  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL
  ------ inclusion threshold ------
      0.045   13.5   0.4       0.28   10.9   0.2    2.2  2  COE1_HLH        Transcription factor COE1 helix-loop-helix do
      0.049   12.7   0.0       0.07   12.2   0.0    1.2  1  Seadorna_VP7    Seadornavirus VP7
      0.082   12.2   0.0       0.16   11.3   0.0    1.4  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  261.6   0.0   4.6e-81   6.9e-78       1     264 []      12     262 ..      12     262 .. 0.94

  Alignments for each domain:
  == domain 1  score: 261.6 bits;  conditional E-value: 4.6e-81
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHH CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseee 99 
                 y++l  +GeGsfG+V+k+++k+t+++vA+K i k+ +++k+ +++++Ei+il+kl+h+niv l+++fe+++e+++v+ey++ gel ++le++  l+ee 
  EFC37645.1  12 YHVLDLIGEGSFGRVFKGRRKQTSQTVALKFIPKKGKNEKELNTLRQEINILRKLDHENIVLLLDSFETNEEFCVVMEYAQ-GELYEILEDDERLPEEI 109
                 789999**********************************99***************************************.66*************** PP

                 HHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-ST CS
     Pkinase 100 akkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppf 197
                 + kia+q++++l y+Hs++iiHrD+Kp+NiLi  +g +K++DFG+a+ +++++  lts+ gt+ Y+APE+++e++y ++vD+WslG+il+el+ gkppf
  EFC37645.1 110 VVKIARQLVSALYYIHSNRIIHRDMKPQNILIGADGTVKLCDFGFARVMSNNTMmLTSIKGTPLYMAPELVQEHPYNHTVDLWSLGIILFELVVGKPPF 208
                 ***************************************************99989******************************************* PP

                 TTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 198 sgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 +   +++     +     i+ i   +k +++ +  is++++++lk ll+k p++Rl +  ll+hp+l
  EFC37645.1 209 Y---TNN-----FFS--LIQLI---VKDTVKYPPYISPTLRSFLKGLLTKSPSQRLDWPRLLDHPFL 262
                 *...222.....222..22233...45689999********************************97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  165.1   0.0   1.2e-51   1.7e-48       5     255 ..      16     256 ..      12     259 .. 0.92

  Alignments for each domain:
  == domain 1  score: 165.1 bits;  conditional E-value: 1.2e-51
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEE.STTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSB CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtl.keeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekeklt 101
                  + +GeG+fG+V++g+ k    +++++Va+K + k++++e+e + l +e++i++kl+h+niv ll     +e+ ++v+ey+ +G+L + L+++  e+l 
   EFC37645.1  16 DLIGEGSFGRVFKGRRK----QTSQTVALKFIpKKGKNEKELNTLRQEINILRKLDHENIVLLLDSFETNEEFCVVMEYA-QGELYEILEDD--ERLP 106
                  679*************9....9999******9788999999**************************************7.59*******97..9*** PP

                  HHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr 102 lkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEif 199
                   + ++++a q+ +++ y++s++++Hrd+  +N+L+  + +vk++DfG ar +  ++++ + ++ k    +mapE ++e+ +++  D Ws G++l+E++
   EFC37645.1 107 EEIVVKIARQLVSALYYIHSNRIIHRDMKPQNILIGADGTVKLCDFGFARVM--SNNTMMLTSIKGTPLYMAPELVQEHPYNHTVDLWSLGIILFELV 202
                  **************************************************99..566666777788888***************************** PP

                  TTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHH CS
  Pkinase_Tyr 200 tlgespypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfsel 255
                    g+ p+ + +  ++++ + ++  ++ p +++++l +++k  ++++p++R +  +l
   EFC37645.1 203 V-GKPPFYTNNFFSLIQLIVKD-TVKYPPYISPTLRSFLKGLLTKSPSQRLDWPRL 256
                  9.*****999999999888665.5788999********************876665 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.028        41      17      73 ..      15      70 ..       2      74 .. 0.83
   2 !   22.3   0.0   4.6e-08   6.8e-05     106     253 ..      70     211 ..      61     250 .. 0.72

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.028
  Kinase-like 17 gellkkgdrsvvfevkdqetgeplavkvfllpseaskkdlerlkeqelairllrgkn 73
                  +l+++g ++ vf+ + ++t + +a+k f+ ++   +k+l+ l+++   +r+l  +n
   EFC37645.1 15 LDLIGEGSFGRVFKGRRKQTSQTVALK-FIPKKGKNEKELNTLRQEINILRKLDHEN 70
                 57999****************999998.55666677899*****9988888887665 PP

  == domain 2  score: 22.3 bits;  conditional E-value: 4.6e-08
  Kinase-like 106 siywvvnallllpaasvdleilnkvlqkrsethkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvl.se 202
                  +i  +++ ++   +  v +e  + +l++  e +++l +     +  ql+    +++++ ++h +++++n+l   +g ++l +f+  +   ++  +  +
   EFC37645.1  70 NIVLLLDSFETNEEFCVVMEYAQGELYEILEDDERLPEEIVVKIARQLVSALYYIHSNRIIHRDMKPQNILIGADGTVKLCDFGFARVMSNNTMMlTS 167
                  55555555666666666666666777777777666655555667778999999****************************99865555444443366 PP

  Kinase-like 203 ve..kgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwclklPltla 253
                  ++    +  pEl+ +           + h +d W lG+  + +   k P+   
   EFC37645.1 168 IKgtPLYMAPELVQE---------HPYNHTVDLWSLGIILFELVVGKPPFYTN 211
                  663445999999998.........347899***********998888887655 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00061      0.91      18     102 ..      33     117 ..      24     125 .. 0.82
   2 !   14.7   0.0   1.5e-05     0.022     166     199 ..     127     158 ..     123     159 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00061
                 ETT--EEEEEE-TT....S-HHHHHHHHHHHHHHHHTT-B--B-CTTBS-EEETTEEEEEEE----EE-SS.HHHHHHHHHHHHHHHHHH CS
         APH  18 tpagryvlrrnppa....raaeeirrevallrlLakagvpvPevlagdtddeeigllfalieyvpgrsllr.klsaaqlpellealgefl 102
                  ++++++l+++p++    ++ +++r+e  +lr L   ++ v  +l+   + e ++   +++ey  g+ ++  +++++  +e++ ++++ l
  EFC37645.1  33 QTSQTVALKFIPKKgkneKELNTLRQEINILRKLDHENI-V-LLLD---SFETNEEFCVVMEYAQGELYEIlEDDERLPEEIVVKIARQL 117
                 445689999998888776778888899999999998888.4.6666...7777777899************9999999999999999987 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.5e-05
                 EEEE-SS-SGGGEEEC..TTEEEEE---TT-EEE CS
         APH 166 tvllHgDlhpgNllvdpddgrvtGviDfedaglg 199
                  +++H+D +p+N+l+ +d++    + Df++a+++
  EFC37645.1 127 NRIIHRDMKPQNILIGADGTVK--LCDFGFARVM 158
                 589*************777777..9*****9986 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.1   3.1e-08   4.7e-05     156     268 ..      56     168 ..       3     177 .. 0.70

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 3.1e-08
  Haspin_kinase 156 vkgtypglllllqdkvlkekpdfyseqqlflvlllkdkGtdLeev...klkswkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtl 248
                    +++  + l  l +++++    d++++++ f+v++   +G+  e +   +    + + +i  q v+ Ly   ++ +  HRd++ +niL+ + ++v l
     EFC37645.1  56 LRQEINILRKLDHENIVLL-LDSFETNEEFCVVMEYAQGELYEILeddERLPEEIVVKIARQLVSALYYIHSN-RIIHRDMKPQNILIGADGTVKL 149
                    3444333333333344444.48888888899887777776544443324555677899999999999999876.788******************* PP

  Haspin_kinase 249 idlklsRlessegkvlytrl 268
                    +d+  +R+  s+++++ t +
     EFC37645.1 150 CDFGFARVM-SNNTMMLTSI 168
                    ********7.6666666665 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.34   5.1e+02     159     209 ..      25      69 ..      19      88 .. 0.69
   2 !   21.9   0.0   4.2e-08   6.3e-05     315     396 ..     117     188 ..     106     199 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.34
  Pkinase_fungal 159 tcwrarkegergkeyvvKdsWrdaerksEaelLkkaeergvegvarlvahe 209
                     +++++r++++  + + +K+  ++ + ++E + L++       ++ r + he
      EFC37645.1  25 RVFKGRRKQTS-QTVALKFIPKKGKNEKELNTLRQE-----INILRKLDHE 69 
                     57888886555.578888888877777887777654.....3444444444 PP

  == domain 2  score: 21.9 bits;  conditional E-value: 4.2e-08
  Pkinase_fungal 315 aIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhD 396
                      + ++   +   +i+HrD   +Nili      ++ +  L D+ +a  +s+  ++       GT+ +ma e+++  eH y h 
      EFC37645.1 117 LVSALYYIH-SNRIIHRDMKPQNILIG-----ADGTVKLCDFGFARVMSN--NTMMLTSIKGTPLYMAPELVQ--EHPYNHT 188
                     566666677.89***************.....8999*************5..55556789*************..7888884 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.1   1.4e-07   0.00021      24     151 ..      26     154 ..      23     166 .. 0.73

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.4e-07
                 SS-HHHHCTTTSTTSTCG--GS-HHHHHHHHHHHHHHHHHHHHHTT.--S--EEEEETT.EEEEE--EETTEEGGBHHHCG.-.HHHHHHHHHHHHHHH CS
        RIO1  24 eFkkrkkyvsgekrfkdrksktnprklvklwaekEfrnLkrleeag.vpvPkpielkrh.vlvmefigedgvaapklkdve.e.eeeaeelyeevleem 118
                 +Fk r+k++s++   k    k+ +++    + ++E+++L++l +++ v   +  e +++ ++vme+ +  g  +  l+d e   ee   ++++++++++
  EFC37645.1  26 VFKGRRKQTSQTVALKFIP-KKGKNEKELNTLRQEINILRKLDHENiVLLLDSFETNEEfCVVMEYAQ--GELYEILEDDErLpEEIVVKIARQLVSAL 121
                 6888888888888877664.44555555566789999***999998555667777765549******9..77777777777334555566666666644 PP

                 HHHHHTSTEEESS-STTSEEEETT.EEEE--GTT CS
        RIO1 119 rklykeaglvHaDLSeyNvlvded.kvviIDvsQ 151
                    ++ ++++H D+   N+l+  d  v + D++ 
  EFC37645.1 122 -YYIHSNRIIHRDMKPQNILIGADgTVKLCDFGF 154
                 .344699***************998888999875 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.12   1.8e+02      22      60 ..      10      49 ..       2      71 .. 0.69
   2 !   16.7   0.0   2.8e-06    0.0042     155     214 ..      93     155 ..      48     156 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.12
        FTA2 22 kdiefleyLgkglhsiVlkvkirgk..eYALKlFrfleaee 60
                +d+  l+++g+g  ++V+k + ++   + ALK F+  + ++
  EFC37645.1 10 DDYHVLDLIGEGSFGRVFKGRRKQTsqTVALK-FIPKKGKN 49
                678889999*********98877644489999.66653332 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 2.8e-06
        FTA2 155 rpiraIVKelellkeqeelevsqlpkllrdlkklhklgIvvrDlkeenyidg.....kLvDlsaa 214
                   ++ I  +    + +ee+ v+++++l++ l  +h+  I++rD+k++n++ g     kL+D++ a
  EFC37645.1  93 GELYEILED--DERLPEEIVVKIARQLVSALYYIHSNRIIHRDMKPQNILIGadgtvKLCDFGFA 155
                 444555555..678899********************************9554446689999976 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.2   4.5e-06    0.0068      50     157 ..      41     146 ..      25     166 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 4.5e-06
  YrbL-PhoP_reg  50 qrekkykqilrElkeyvqlsklreeidnsplarilGlvqTdlGlGlvvekirdadGnvaktLedlvk.keeltaelkeaLdefleelldnhivtnd 144
                    +   k+ ++++El+   q+    ++ d   +  +l + +T+    +v+e    a+G++ + Led  +  ee+  +++++L   l ++  n+i+ +d
     EFC37645.1  41 KFIPKKGKNEKELNTLRQEINILRKLDHENIVLLLDSFETNEEFCVVMEY---AQGELYEILEDDERlPEEIVVKIARQLVSALYYIHSNRIIHRD 133
                    44444555666666666666666667777777777788888888887775...7899999999988634667778********************* PP

  YrbL-PhoP_reg 145 lsakNivvkknse 157
                    ++++Ni+++ + +
     EFC37645.1 134 MKPQNILIGADGT 146
                    *******998765 PP

>> COE1_HLH  Transcription factor COE1 helix-loop-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.2   0.00018      0.28      23      44 .]     101     122 ..     100     122 .. 0.96
   2 ?   -0.6   0.0      0.76   1.1e+03       7      14 ..     151     158 ..     149     159 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00018
    COE1_HLH  23 DperLpkeiILkRAAdlaEaly 44 
                 D erLp ei+ k A +l+ aly
  EFC37645.1 101 DDERLPEEIVVKIARQLVSALY 122
                 88******************99 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.76
    COE1_HLH   7 dyGFqRLl 14 
                 d+GF R +
  EFC37645.1 151 DFGFARVM 158
                 9*****86 PP

>> Seadorna_VP7  Seadornavirus VP7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   4.7e-05      0.07     151     194 ..     118     161 ..      90     171 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 4.7e-05
  Seadorna_VP7 151 lkdLmdfhsestnllhGDcnpenlmcDknGylklvDPv..sLlert 194
                   +++L  +h  s+ ++h D++p+n++    G +kl D +   +++++
    EFC37645.1 118 VSALYYIH--SNRIIHRDMKPQNILIGADGTVKLCDFGfaRVMSNN 161
                   56788888..789**********************96411456555 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0    0.0001      0.16     105     166 ..      95     152 ..      87     162 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.0001
         Kdo 105 LedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDl 166
                 L ++l++ ++l+ee   ++ +++  +   +h+  + H+d+ ++nil+ +++    ++ l D+
  EFC37645.1  95 LYEILEDDERLPEEIVVKIARQLVSALYYIHSNRIIHRDMKPQNILIGADG----TVKLCDF 152
                 555666633355555555555555566779*****************9999....7777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       505  (0.0281667); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 1747.64
//
Query:       EFC37646.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0087   15.6   4.0     0.0087   15.6   4.0    2.6  3  MscS_porin       Mechanosensitive ion channel porin domain
  ------ inclusion threshold ------
      0.021   15.2   4.3      0.021   15.2   4.3    2.4  2  Mis14            Kinetochore protein Mis14 like
      0.058   13.6   0.1       0.47   10.6   0.0    2.5  2  AsnC_trans_reg2  AsnC-like ligand binding domain
       0.35    9.6   8.2      0.055   12.3   2.3    2.0  2  Glypican         Glypican
       0.72    9.9  14.4        3.3    7.8   0.8    2.6  2  TPR_MLP1_2       TPR/MLP1/MLP2-like protein
       0.84    9.8   9.1       0.91    9.7   3.0    2.2  2  GIDA_assoc       GidA associated domain
        1.1    9.4   7.3        6.9    6.8   1.1    2.6  2  Cob_adeno_trans  Cobalamin adenosyltransferase
        1.1    9.9   4.0         19    5.9   4.0    2.4  1  DUF3800          Protein of unknown function (DUF3800)
        1.6    9.7   5.0        4.4    8.3   0.2    2.6  2  Gastrin          Gastrin/cholecystokinin family
          4    7.5   9.5         16    5.5   0.6    2.3  2  Med7             MED7 protein
        4.4    7.2  16.7       0.57   10.1   5.1    2.5  2  Cauli_AT         Aphid transmission protein
        9.9    6.7  10.8        9.1    6.8   0.0    3.4  3  Cep57_MT_bd      Centrosome microtubule-binding domain of Cep


Domain annotation for each model (and alignments):
>> MscS_porin  Mechanosensitive ion channel porin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       4.2   6.2e+03     162     175 ..       7      20 ..       5      22 .. 0.77
   2 ?    0.9   2.5      0.19   2.8e+02      36      99 ..     145     208 ..     142     213 .. 0.75
   3 !   15.6   4.0   5.8e-06    0.0087      12      74 ..     285     347 ..     278     373 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.2
  MscS_porin 162 eaqieeleqellsn 175
                 e+ ++++++el++ 
  EFC37646.1   7 ETSNQMRRLELENL 20 
                 67899999999876 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.19
  MscS_porin  36 kkkaeelqkaiddaPkelrelqqelealqkkkeeaskeilaklsleeLeqrllqtssqlqelqe 99 
                  ++a+e+q+ i++    l+++  +l+   ++++++ k++  + sl+ L  + ++t  +l++++ 
  EFC37646.1 145 IERAKEFQQFIEELKLNLANILTSLALSVQTNAKSKKKKKINESLAVLIEKSKKTFKELMNTED 208
                 5899999999999999999999999999555555666666677777777777777777777665 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 5.8e-06
  MscS_porin  12 eaeqkallqdLeqalnlLdkidkskkkaeelqkaiddaPkelrelqqelealqkkkeeaskei 74 
                  +++k+   +L+ a n L++++  k k ++l+k i+++ ++l++l+ +  +l++k ++++k++
  EFC37646.1 285 RKKRKKKERNLTTATNGLEETETRKTKKNNLEKLIEEYEQKLKDLESHCISLNNKIDSPPKTD 347
                 566889999*******************************************99998888876 PP

>> Mis14  Kinetochore protein Mis14 like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   1.5      0.75   1.1e+03      73     130 ..     149     206 ..     143     210 .. 0.50
   2 ?   15.2   4.3   1.4e-05     0.021      37     128 ..     226     330 ..     223     333 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.75
                 HHCCCHHHHHHCT.--HHHHH--.....------SSSHHHHHHHHHHHHHHHHHHHHHHHHH CS
       Mis14  73 kelkaeleeldey.leainelek...qekkdpeeddededekerleelvkqyeeslkslkel 130
                 ke+++ +eel+    +++         +++  +++++++++ e l  l+++ ++++k+l ++
  EFC37646.1 149 KEFQQFIEELKLNlANIL----TslaLSVQTNAKSKKKKKINESLAVLIEKSKKTFKELMNT 206
                 566666666666202233....2344233333334444555555555666666666665555 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 1.4e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCT--HHHHH--................------SSSHHHHHHHHHHHHHHHH CS
       Mis14  37 elnekvrslyqelEdltvevAqlRreaPrkiaeayakelkaeleeldeyleainelek..............qekkdpeeddededekerleelvkqye 121
                 e  e+v+ l++e+E+l v +++l re+ +  ++a ++  +a  e++ +   +++++ek                ++  ee+++ ++ k++le+l+++ye
  EFC37646.1 226 ESTEQVKTLIDEIEHLAVSISTLNRELLSLFKPALEDLGSAVKEIVGQ-PTIVKPVEKverkkrkkkernltTATNGLEETETRKTKKNNLEKLIEEYE 323
                 6789*******************************************9.999999*999999***9999999999999999999999999********* PP

                 HHHHHHH CS
       Mis14 122 eslkslk 128
                 + lk+l+
  EFC37646.1 324 QKLKDLE 330
                 *999986 PP

>> AsnC_trans_reg2  AsnC-like ligand binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0         1   1.6e+03      44      62 ..     103     121 ..     102     161 .. 0.78
   2 ?   10.6   0.0   0.00031      0.47      40      66 ..     215     241 ..     181     254 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1
  AsnC_trans_reg2  44 lyfmvharseeeveevlae 62 
                      +++m  a+s++e e+ l++
       EFC37646.1 103 IFTMAKANSRTERERALEN 121
                      5788888888887777664 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00031
  AsnC_trans_reg2  40 wpynlyfmvharseeeveevlaeiaaa 66 
                       +yn+++ + a+s e+v++ ++ei++ 
       EFC37646.1 215 FKYNCFALLKAESTEQVKTLIDEIEHL 241
                      48**********************975 PP

>> Glypican  Glypican
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.6     0.074   1.1e+02      82     137 ..     182     238 ..     146     256 .. 0.60
   2 ?   12.3   2.3   3.7e-05     0.055     298     398 ..     237     340 ..     221     348 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.074
    Glypican  82 ssslqalletrakkfdeffrellkksekslnelFs.ktYgrlytqnaelfkelftel 137
                  ++++  l+   +k  ++f+el+++ + +   +F+ + +  l  +++e +k l  e+
  EFC37646.1 182 KKKINESLAVLIEKSKKTFKELMNTEDAVATWMFKyNCFALLKAESTEQVKTLIDEI 238
                 334444444444555556666666666666666652345555566666666666665 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 3.7e-05
    Glypican 298 nienviksievkiseaimalqeNseklskkvfkgCgtpkktqarsersskdeekkkrglktaep..eeket.taagtkldrlvtelkekLkkvkkfwvs 393
                 +ie+ + si++   e +   +   e l + v+ + g+p  ++   + + k+++kk+r+l+ta++  ee et + ++++l++l+ e  +kLk++ ++ +s
  EFC37646.1 237 EIEHLAVSISTLNRELLSLFKPALEDLGSAVKEIVGQPTIVKPVEKVERKKRKKKERNLTTATNglEETETrKTKKNNLEKLIEEYEQKLKDLESHCIS 335
                 567777777777778788888888999999*********998877777777777777777776422344441445678*****************9999 PP

    Glypican 394 Lpdtl 398
                 L +++
  EFC37646.1 336 LNNKI 340
                 98876 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.8    0.0022       3.3       7      80 ..     179     252 ..     173     269 .. 0.91
   2 ?    7.3   5.6    0.0032       4.8      71     127 ..     285     341 ..     276     342 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0022
  TPR_MLP1_2   7 eeeikslkeekeeaeaklqklqedlekqaeiakeaqqkYerelvkhaedvkelqalreelnelkaeiaelkaea 80 
                  +++k+++e+ + + +k +k  ++l + ++ +++   kY    +++ae ++++++l +e+++l   i++l+ e+
  EFC37646.1 179 SKKKKKINESLAVLIEKSKKTFKELMNTEDAVATWMFKYNCFALLKAESTEQVKTLIDEIEHLAVSISTLNREL 252
                 5788999999************************************************************9887 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0032
  TPR_MLP1_2  71 aeiaelkaeaesakaeleeseesweeqkeelekelselekriedlneqNklLhdQlE 127
                  + ++ k+++ ++ ++  e++e  +++k++lek ++e e++++dl+++   L ++++
  EFC37646.1 285 RKKRKKKERNLTTATNGLEETETRKTKKNNLEKLIEEYEQKLKDLESHCISLNNKID 341
                 444444444444444445556677999******************998777766666 PP

>> GIDA_assoc  GidA associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   3.0   0.00061      0.91      93     186 ..     133     233 ..      94     256 .. 0.78
   2 ?    3.9   0.4     0.037        55      74     126 ..     284     337 ..     264     364 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00061
                 H........HHHT....EHHHHCTTST--HHHHHCCHHHHHHHSCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHTSB--TTS-CCCSTT--CHHHHHH CS
  GIDA_assoc  93 l.......lekkeskklslaellkrpevkledlleelpeeeeeseeeleqveieakYegyiekqeeeieklkkeenlkipedldYskikgLskearekL 184
                         +++k ++++++ +++++ +++l+++l++l+ + +++++++++ +i+   + +iek +++ ++l + e+      ++Y+  + L++e+ e+ 
  EFC37646.1 133 SfhvrnfvSVEKIERAKEFQQFIEELKLNLANILTSLALSVQTNAKSKKKKKINESLAVLIEKSKKTFKELMNTEDAVATWMFKYNCFALLKAESTEQV 231
                 1233334456666677788999999999999999998888888888899******************************************99999987 PP

                 HH CS
  GIDA_assoc 185 kk 186
                 k+
  EFC37646.1 232 KT 233
                 75 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.037
                 HHHHHHHCCEEEHHHHHHHH..HHHT....EHHHHCTTST--HHHHHCCHHHHH CS
  GIDA_assoc  74 eelkellkstklkseewkkl.lekkeskklslaellkrpevkledlleelpeee 126
                 e+ k++ k+ +l+++++  + +e++++kk +l +l+++ e kl+dl++++ + +
  EFC37646.1 284 ERKKRKKKERNLTTATNGLEeTETRKTKKNNLEKLIEEYEQKLKDLESHCISLN 337
                 333333333333222211112344555555777777777777777766665554 PP

>> Cob_adeno_trans  Cobalamin adenosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.7     0.017        26      50     100 ..     148     202 ..     132     217 .. 0.68
   2 ?    6.8   1.1    0.0046       6.9      70     111 ..     294     335 ..     224     342 .. 0.67

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.017
                      THHHHHHHHHHHHHHHHHHHHHHT.....-BTCCG-S--HHHHHH.HHHHHHHHHH CS
  Cob_adeno_trans  50 eeelkeaLeeiqneLfdlgaelatp....ekkkekkkiteeevee.lekeidelea 100
                      ++e+++ +ee++ +L ++ ++la +    +k+k+kkki+e+ ++  +ek  +++++
       EFC37646.1 148 AKEFQQFIEELKLNLANILTSLALSvqtnAKSKKKKKINES-LAVlIEKSKKTFKE 202
                      67999*****************9887665555666666666.43324444444443 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0046
                      HHHT.-BTCCG-S--HHHHHHHHHHHHHHHHHS--EESEEES CS
  Cob_adeno_trans  70 elatpekkkekkkiteeeveelekeideleaelpplksfilp 111
                      +l t ++  e+++ ++ + ++lek i+e+e++l+ l+s+ + 
       EFC37646.1 294 NLTTATNGLEETETRKTKKNNLEKLIEEYEQKLKDLESHCIS 335
                      333335555555555555688***************998876 PP

>> DUF3800  Protein of unknown function (DUF3800)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   4.0     0.013        19      25      77 ..     143     237 ..      59     374 .] 0.58

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.013
     DUF3800  25 kkieeikkleekikelkkky...................................................krlleriakflkkndlik.......sde 65 
                 +kie+ k+++++i+elk ++                                                   +                        ++ 
  EFC37646.1 143 EKIERAKEFQQFIEELKLNLaniltslalsvqtnakskkkkkineslavliekskktfkelmntedavatwM----------------FkyncfalLKA 225
                 556688999999999988884444444444444444444444444442222222222222222222222220................02333333333 PP

     DUF3800  66 esdesilivldk 77 
                 es+e+++ ++d+
  EFC37646.1 226 ESTEQVKTLIDE 237
                 333333333333 PP

>> Gastrin  Gastrin/cholecystokinin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   1.0      0.17   2.5e+02      38      93 ..     131     188 ..      95     211 .. 0.54
   2 ?    8.3   0.2     0.003       4.4      29      96 ..     277     342 ..     252     349 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.17
     Gastrin  38 eaqrharaaasskqlkalqrade.eedqranlseLLarl.lsqkkkgsvrrlsaaksr 93 
                 +++ h+r+ +s ++++ +++ ++  e+ + nl ++L+ l ls + ++++++ + +++ 
  EFC37646.1 131 KNSFHVRNFVSVEKIERAKEFQQfIEELKLNLANILTSLaLSVQTNAKSKKKKKINES 188
                 4455555544444443333333322344555555555543333333444444444332 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.003
     Gastrin  29 leeaeesleeaqrharaaasskqlkalqradeeedqranlseLLarllsqkkkgsvrrlsaaksrlqs 96 
                 ++  e+ +e+++r+ + +  + +++ l+++++ + +++nl +L+  + ++ k +    + +++++++s
  EFC37646.1 277 VKPVEK-VERKKRKKKERNLTTATNGLEETETRKTKKNNLEKLIEEYEQKLK-DLESHCISLNNKIDS 342
                 333343.455566666666777889999999999999999999999988887.888888888887765 PP

>> Med7  MED7 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.6     0.011        16      87     139 ..     134     185 ..     120     195 .. 0.78
   2 ?    3.7   5.7     0.039        59      65     190 ..     215     339 ..     174     340 .. 0.69

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.011
        Med7  87 qgieqlyeedesedrkkeLkkLlrslllnfleLlgillknPeqsefeekvedl 139
                 + +++++ + e+++r+ke++++ ++l ln  ++l  l+   + + +++k +++
  EFC37646.1 134 FHVRNFV-SVEKIERAKEFQQFIEELKLNLANILTSLALSVQTNAKSKKKKKI 185
                 5566777.8899************************99987443344444444 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.039
        Med7  65 geYrvFGenwsllkdklpsLeeqgieqlyeedesedrkkeLkkLlrslllnfleLlgillknPeqsefeekve..dlrllliNmhhllNeyRphQAret 161
                  +Y++F       ++++++L + +ie l    +  + ++eL +L++  l    + ++ ++ +P+  +  ekve  + ++   N+  + N + +  +r+t
  EFC37646.1 215 FKYNCFALLKAESTEQVKTLID-EIEHLA--VSISTLNRELLSLFKPALEDLGSAVKEIVGQPTIVKPVEKVErkKRKKKERNLTTATNGLEETETRKT 310
                 5566665555444555555554.566666..555566777777777777777777777777775445556654114567789***************** PP

        Med7 162 lillleeqleekreeiekirkkceevkev 190
                  ++ le+ +ee ++++++++++c +++++
  EFC37646.1 311 KKNNLEKLIEEYEQKLKDLESHCISLNNK 339
                 ***********************998876 PP

>> Cauli_AT  Aphid transmission protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   3.8     0.084   1.2e+02      53     163 .]     154     272 ..     129     272 .. 0.63
   2 ?   10.1   5.1   0.00038      0.57      86     161 ..     292     367 ..     279     368 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.084
    Cauli_AT  53 ivarslLklskllsylGLekDesealsksksPfgs....vfkklkkifkeggedkekktklle.....tLkeaqn..rikkleeetkklaekivtekll 140
                  +    L+l+ +l  l L+  +    sk+k+ +++    + +k kk fke  + +++ ++ +       L +a++  ++k l +e+++la  i    l 
  EFC37646.1 154 FIEELKLNLANILTSLALSVQTNA-KSKKKKKINEslavLIEKSKKTFKELMNTEDAVATWMFkyncfALLKAESteQVKTLIDEIEHLAVSI--STLN 249
                 555666888888888888877655.45555544431221567888999998877777665443011112333322234444444444444443..4577 PP

    Cauli_AT 141 keevkdlderlseirdslkaiiG 163
                 +e +  ++  l+ + + +k+i+G
  EFC37646.1 250 RELLSLFKPALEDLGSAVKEIVG 272
                 88888999999999999999998 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00038
    Cauli_AT  86 gsvfkklkkifkeggedkekktklletLkeaqnrikkleeetkklaekivtekllkeevkdlderlseirdslkai 161
                 ++ ++++++ ++e++  k+kk +l + ++e +++ k+le +  +l++ki + +++++ +  ++++ s + d+l++i
  EFC37646.1 292 ERNLTTATNGLEETETRKTKKNNLEKLIEEYEQKLKDLESHCISLNNKIDSPPKTDSLLNPFYRKESGLTDKLRSI 367
                 467888999999****************************************************999999999876 PP

>> Cep57_MT_bd  Centrosome microtubule-binding domain of Cep57
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1       1.4     2e+03      46      62 ..     178     194 ..     149     204 .. 0.63
   2 ?    6.8   0.0    0.0061       9.1      17      41 ..     231     255 ..     226     273 .. 0.85
   3 ?    2.6   3.5      0.12   1.8e+02      28      67 ..     289     325 ..     276     332 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.4
  Cep57_MT_bd  46 gkrkRkdLaeeleelvk 62 
                   ++k+k+++e+l  l++
   EFC37646.1 178 KSKKKKKINESLAVLIE 194
                  44445555555444443 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0061
  Cep57_MT_bd  17 lkeLedEfehlklelqelaaqynal 41 
                  +k+L dE+ehl +  ++l++++ +l
   EFC37646.1 231 VKTLIDEIEHLAVSISTLNRELLSL 255
                  79999************99998665 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.12
  Cep57_MT_bd  28 klelqelaaqynaldpslgkrkRkdLaeeleelvkrlEaK 67 
                  k++   l    n l+   + + Rk+ +++le+l+++ E+K
   EFC37646.1 289 KKKERNLTTATNGLE---ETETRKTKKNNLEKLIEEYEQK 325
                  555555666666666...8999****************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2505  (0.139718); expected 358.6 (0.02)
Passed bias filter:                      691  (0.0385409); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2059.20
//
Query:       EFC37647.1  [L=335]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.8e-40  137.8   0.0    4.8e-40  137.0   0.0    1.4  1  OTCace_N       Aspartate/ornithine carbamoyltransferase, carb
    1.9e-24   86.5   0.0    3.1e-24   85.8   0.0    1.3  1  OTCace         Aspartate/ornithine carbamoyltransferase, Asp/
  ------ inclusion threshold ------
      0.093   13.2   0.0        1.2    9.6   0.0    2.3  2  Lectin_C_term  Ricin-type beta-trefoil lectin C-terminal doma
        0.1   13.1   0.0       0.54   10.8   0.0    2.0  2  Agglutinin_C   Agglutinin C-terminal


Domain annotation for each model (and alignments):
>> OTCace_N  Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.0   0.0   1.1e-43   4.8e-40       1     148 []      16     160 ..      16     160 .. 0.91

  Alignments for each domain:
  == domain 1  score: 137.0 bits;  conditional E-value: 1.1e-43
                 S-BSSGGGS-HHHHHHHHHHHHHHHHHHHT...TT-STTTTT-EEEEEESS--HHHHHHHHHHHHHTTSEEEEEESTTTSCTTTGGSTTSSCHHHHHHH CS
    OTCace_N   1 rhllsledlskeeieelldlaaelkekvkk...ekkekllkgktlallFeepStRTrvSfevAakrlGgkvlslseaediqlssvskgrkEsleDtarv 96 
                 ++lls+++++k+ ie+l  +a e+k+ +k+   +++++ l++k++ llF+epStRT +Sf++A+ +lGgk+++l+    iq+ss  kg  Esl+Dt+r+
  EFC37647.1  16 KSLLSIKQVDKSLIEQLSLRAGEFKNYHKTkqyHQYNTVLSDKIVNLLFFEPSTRTLCSFQSAVLKLGGKPITLD----IQSSSSVKG--ESLQDTLRT 108
                 689**********************99888666666777***********************************9....568888999..********* PP

                 HHHHTSEEEEEESSHHHHHHHHHHHSSEEEEEEETSSB-HHHHHHHHHHHHH CS
    OTCace_N  97 lsryvdaiviRhpgaeeleelakyasvpviNagdgdgeHPtQaLaDlltire 148
                 +++y+d+ v+Rhp+    +e+    + p+iNagdgdgeHPtQaL+Dl+ti e
  EFC37647.1 109 MEQYGDLTVMRHPKRGVHQEVLPKLEKPLINAGDGDGEHPTQALLDLFTITE 160
                 *************55445666666689***********************87 PP

>> OTCace  Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.8   0.0     7e-28   3.1e-24       3     156 ..     174     331 ..     172     332 .. 0.88

  Alignments for each domain:
  == domain 1  score: 85.8 bits;  conditional E-value: 7e-28
                 .EEEEESS.TTSHHHHHHHHHHHH.C...T-EEEEES-TTSSH-HHHHHHHHHHHHHHT-EEEEESSCHHHHTT-SEEEE--SSETTCCGGHHHHHHHH CS
      OTCace   3 lkiafvGd.kknnvanslikllar.l...gmdvvlvaPkglepdkevleeakknakksggsititedleeavkgaDvvytdvwvsmgeekereerlkkl 96 
                 ++i++ Gd k +++++sl++ll + +    ++++l++P gl++   v+ee+ kn+ +  + ++ ++   e +k+ Dv+y ++++  +e  e e+++ ++
  EFC37647.1 174 KTICMFGDlKFGRTVHSLLRLLYKyYntqPLKLYLISPSGLKMPDYVIEECVKNYGNVHEIVECEKLTPEIMKELDVIYATRLQ--KERFENEDQYLSY 270
                 689****************99888332224679*******99999*********988888888888888***************..5556677889999 PP

                 CC.CSB-HHHHHHS-T.T.-EEEE-S---BTTTB-HHHHTSTTBHHHHHHHHHHHHHHHHHHH CS
      OTCace  97 kd.yqvteellklakk.d.aivlHcLPakrgeEvtdeVfdsprsvvfeqaeNrlhtikAllvl 156
                 k  + + ++ l++ ++ +  i++H+LP  r +E++++++ ++r+++f+q++N++++++A+l l
  EFC37647.1 271 KSsFCLKKDDLQHSRNqHlPIIMHPLP--RVDELDESIDTDERAAYFRQMNNGVYMRMAILEL 331
                 988*********999954369******..*******************************987 PP

>> Lectin_C_term  Ricin-type beta-trefoil lectin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00027       1.2      72     100 ..      41      69 ..      14      71 .. 0.81
   2 ?    1.1   0.0      0.13   5.7e+02      29      59 ..     253     282 ..     231     293 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00027
  Lectin_C_term  72 g.rqaenehAYnvvlddqdkskvyffEPqn 100
                    + +++++ h Yn vl+ ++  ++ ffEP +
     EFC37647.1  41 NyHKTKQYHQYNTVLS-DKIVNLLFFEPST 69 
                    35689999********.8999*******87 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.13
  Lectin_C_term  29 sqeyrknkyDcddfAlalkgelakWrndnlr 59 
                        +k++++ +d  l+ k++++  ++d+l+
     EFC37647.1 253 ATRLQKERFENEDQYLSYKSSFC-LKKDDLQ 282
                    56678999*****99******99.6666554 PP

>> Agglutinin_C  Agglutinin C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00012      0.54      65      92 ..      44      71 ..      35      72 .. 0.89
   2 ?   -0.7   0.0      0.47   2.1e+03       9      46 ..     241     279 ..     235     291 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00012
  Agglutinin_C 65 stkgkkayNvvlsqdlskvvffdpqtgk 92
                  +tk+ + yN vls++  +++ff+p+t++
    EFC37647.1 44 KTKQYHQYNTVLSDKIVNLLFFEPSTRT 71
                  567889*******************986 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.47
  Agglutinin_C   9 lesiwkesgl.kkqklrkelFdcddfalvfkaavakwan 46 
                   + +i ke+++   ++l+ke F+ +d  l +k+  + +++
    EFC37647.1 241 TPEIMKELDViYATRLQKERFENEDQYLSYKSSFCLKKD 279
                   556777777755668999999999999999988776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       709  (0.0395449); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1890.46
//
Query:       EFC37648.1  [L=310]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      1e-40  140.4   0.1    1.3e-40  140.1   0.1    1.1  1  Metallophos  Calcineurin-like phosphoesterase
    1.2e-19   70.5   2.2    1.5e-19   70.2   1.4    1.7  2  STPPase_N    Serine-threonine protein phosphatase N-terminal 


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  140.1   0.1   1.4e-44   1.3e-40       2     201 ..      62     253 ..      61     256 .. 0.94

  Alignments for each domain:
  == domain 1  score: 140.1 bits;  conditional E-value: 1.4e-44
                  EEEEEESBTBTTCCTHHHHHHHHHHHH..HHHTTESEEEEESTSSSSSHHHHHHHHH.HHHHHHHTSEEEEEC-TTS........CHHHHHHHHHHHH CS
  Metallophos   2 rilvigDlHlalgggqlddllkllddl..lreekpdlvllaGDlvdrgdlekellel.laalvkypipvylllGNHe........gfeeellnkygyl 88 
                  +i ++gD+H     gq++dll+l++    ++e  ++l+l  GD+vdrg  + e++ l la+++kyp +++ll+GNHe        gf++e++++y   
   EFC37648.1  62 PIKICGDVH-----GQYYDLLRLFEYGgfPPE-ANYLFL--GDYVDRGKQSLETICLlLAYKIKYPENFFLLRGNHEcasinriyGFYDECKRRYS-- 149
                  6889*****.....**********77753555.99****..*******77777777779***********************************99.. PP

                  HHHHHHHEHHHCEEETSEEEEEETTEEEEEEEESE.CEEETHHHHHHHHHHHSCHHHHCC...HHHHHHHHHHTTCSEEEEEESSESSCSSSCSCCHH CS
  Metallophos  89 gifsepwrsdaevfnnlplaslgsgslkvlllhGg.spellvsldklgslnleleapepg...dewlkdlekrekadwvivlgHsplyrgsgylfgde 182
                      ++w+s++++fn++p+a++++   k++++hGg spel ++ ++++++ +++++p++g   d++++d       +   + g+  + rg + +fg++
   EFC37648.1 150 ---IRLWKSFTDCFNCMPVAAIIDE--KIFCMHGGlSPEL-HNMEQIRKVMRPTDVPDSGllcDLLWSD-------PEEGIQGWGENDRGVSFTFGND 234
                  ...9*********************..********88888.****************************.......999999999999********** PP

                  HHHHHHHHTTESEEEEESS CS
  Metallophos 183 aledllkkygvdlvisGHt 201
                  ++e++lkk+++dlv+++H+
   EFC37648.1 235 VVEKFLKKHDLDLVCRAHQ 253
                  ******************8 PP

>> STPPase_N  Serine-threonine protein phosphatase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.2   1.4   1.7e-23   1.5e-19       1      48 []      13      60 ..      13      60 .. 0.97
   2 ?   -3.4   0.0       1.6   1.4e+04      21      32 ..     239     250 ..     237     251 .. 0.81

  Alignments for each domain:
  == domain 1  score: 70.2 bits;  conditional E-value: 1.7e-23
   STPPase_N  1 vDdiIerLlevrgkpggkkvqLseaEIrqlCakareiFLsQPtLLeLe 48
                +D iI +Llevrg+++gk+v L+e+EI+ql+ k+reiF+sQP LLeLe
  EFC37648.1 13 IDAIIFKLLEVRGSRPGKQVSLTENEIKQLILKSREIFISQPALLELE 60
                8************8888******************************7 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.6
   STPPase_N  21 qLseaEIrqlCa 32 
                  L+ +++ ++C+
  EFC37648.1 239 FLKKHDLDLVCR 250
                 589999999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       396  (0.0220871); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 2099.37
//
Query:       EFC37649.1  [L=354]
Description: hypothetical protein NAEGRDRAFT_81882 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-07   31.5   0.0    0.00042   20.2   0.0    2.2  2  Abhydrolase_2    Phospholipase/Carboxylesterase
  ------ inclusion threshold ------
       0.11   12.4   0.1        0.2   11.7   0.1    1.4  1  Gram_pos_anchor  LPXTG cell wall anchor motif


Domain annotation for each model (and alignments):
>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0   0.00011      0.95      68     127 ..      88     152 ..      79     177 .. 0.78
   2 !   20.2   0.0   4.7e-08   0.00042     153     216 ..     283     347 ..     271     348 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00011
                    -B--SSTTS..-B-HHHHHHHHHHHHHHHHHHHHTT...--GGGEEEEEETHHHHHHHHHHHT-S CS
  Abhydrolase_2  68 dlvglspek..kedeagikksaekleelidaelkkg...ipssriiigGFSqGaalalylaltlp 127
                    dl++l+++   k de   +  a++l + i ++ +k     + ++ ++gGF  G+++++  a  l 
     EFC37649.1  88 DLFELDEKVygKVDELTLHSYAKQLTAYIVKNYEKEildKDFEQFFVGGFCVGGMISIFVAQELM 152
                    677888887888999999999999999999999999433355789***********997665544 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 4.7e-08
                    GGGG-EEEEEEETT-SSS-HHHHHHHHHHHHTTS-.GEEEEEETT--SS--HHHHHHHHHHHHHH CS
  Abhydrolase_2 153 vtkklpilqiHgeeDpvvplalgkaakevlkkllk.kvelksyeglaHsideeemqdikeflkkl 216
                     + +lpi ++Hg+ D+++ + l + + +     +k ++ l++++ ++H  + + m+++ +f++  
     EFC37649.1 283 FNNDLPISHLHGDNDYLLRSNLCESFVKQQVLPNKgNYRLRVMKHSGHFLPLTRMNAVTNFIYNI 347
                    5679******************999877666666668*************************865 PP

>> Gram_pos_anchor  LPXTG cell wall anchor motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   2.2e-05       0.2      18      43 .]       2      28 ..       1      28 [. 0.87

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.2e-05
                     XXXXXXXXXXXXXXXXX.XXXXXXXX. CS
  Gram_pos_anchor 18 ifltaaGllallggllL.lvkrRKkek 43
                     + l+ aG+++l+gg+   l++ +K+++
       EFC37649.1  2 TTLLYAGIAVLVGGGYYlLFSNKKENN 28
                     7899************98888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       608  (0.0339115); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 2381.85
//
Query:       EFC37650.1  [L=147]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      2e-28   98.8   0.3    2.3e-28   98.6   0.3    1.0  1  UQ_con     Ubiquitin-conjugating enzyme
    4.7e-06   26.4   0.0    5.9e-06   26.0   0.0    1.2  1  Prok-E2_B  Prokaryotic E2 family B
      0.005   16.7   0.2     0.0061   16.4   0.2    1.2  1  UEV        UEV domain
  ------ inclusion threshold ------
      0.067   12.8   0.1       0.32   10.6   0.0    2.0  3  UFC1       Ubiquitin-fold modifier-conjugating enzyme 1


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   98.6   0.3   5.2e-32   2.3e-28       1     129 [.       5     134 ..       5     144 .. 0.84

  Alignments for each domain:
  == domain 1  score: 98.6 bits;  conditional E-value: 5.2e-32
                 HHHHHHHHHHHSTTTTEEEEEEET.TEECEEEEEEEB.TTSTTTTEEEEEEEE--TTTTTS--EEEESS..T-SCTTBETTSBB-CGGGSTTT--TTSH CS
      UQ_con   1 rlqkelkelakkkpsgisaklvdd.enlfewkvlikgpedtpYeggvFklelefpedYPlkpPkvkfvt..kifHPnvdksGevcldiLkeekWspalt 96 
                 r+qke+++l   +  gi+  + +  +nl ++ ++++g+++t+Y g+ + l+++f++dYPl++P+v fv     +H +v+++G++cl+iL +  W+p+++
  EFC37650.1   5 RIQKEIQKLG--SGVGIDIFINQPiNNLETIYCTLHGARNTIYSGEQYLLKFTFSNDYPLQSPEVVFVPphVPLHEHVYTNGHICLNILYDG-WTPVMN 100
                 6778887643..333444444443359*****************************************644789****************66.****** PP

                 HHHHHHHHHHHHHS-.-TTS-SSHHHHHHHHHTH CS
      UQ_con  97 lesvllsiqsLlaep.npesplnkeaakllkkdr 129
                 ++sv++siqs+l++  ++++p++++ + + ++++
  EFC37650.1 101 IQSVCMSIQSMLSSAtQKKKPIDNDTYVMSCSHS 134
                 ************98889**********9998873 PP

>> Prok-E2_B  Prokaryotic E2 family B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.0   0.0   1.3e-09   5.9e-06      34     111 ..      46     118 ..      18     128 .. 0.86

  Alignments for each domain:
  == domain 1  score: 26.0 bits;  conditional E-value: 1.3e-09
   Prok-E2_B  34 sggtvdlrlvypdsfpllppavflqdpeqlkllpHintfggaLClleeeldldewdpngsvadvleqlqqvLn.egisg 111
                 sg ++ l++ +++++pl  p v+ + p  ++l  H++t +g +Cl       d w+p ++++ v  ++q +L  +++  
  EFC37650.1  46 SGEQYLLKFTFSNDYPLQSPEVVFVPPH-VPLHEHVYT-NGHICL---NILYDGWTPVMNIQSVCMSIQSMLSsATQ-K 118
                 799999*******************999.89*******.******...8***********************94444.3 PP

>> UEV  UEV domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.2   1.4e-06    0.0061      55     121 .]      55     122 ..      19     122 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.4e-06
                 E--TTTTTS--EEEE-GCC--TSGGGGGB-TTSBB--HHHHS.--T..TT--HHHHHHHHHH.-----XXX CS
         UEV  55 wvlesyPveaPivyvkptksmvikknenvdaqGlvylpyLee.Wkr..eksnlvslvqelaq.afeeesPl 121
                    ++yP + P v+  p +   +  +e+v ++G + l++L + W++  + +++ + +q++ + a ++++P+
  EFC37650.1  55 TFSNDYPLQSPEVVFVPPH---VPLHEHVYTNGHICLNILYDgWTPvmNIQSVCMSIQSMLSsATQKKKPI 122
                 45689******87777765...47899*************6537775444447788888776577777786 PP

>> UFC1  Ubiquitin-fold modifier-conjugating enzyme 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.036   1.6e+02      70     116 ..      10      56 ..       5      62 .. 0.83
   2 ?   10.6   0.0   7.2e-05      0.32      75     116 ..      50      92 ..      38     116 .. 0.81
   3 ?   -1.4   0.0      0.36   1.6e+03      38      60 ..     116     140 ..     101     143 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.036
        UFC1  70 lkkyefdlefdipvtypataleialpeldgktakmyrgGkicltihf 116
                 ++k    + +di ++ p  +le     l+g  + +y g +  l+  f
  EFC37650.1  10 IQKLGSGVGIDIFINQPINNLETIYCTLHGARNTIYSGEQYLLKFTF 56 
                 55666678899999**********************99988777666 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 7.2e-05
        UFC1  75 fdlefdipvtypataleia.lpeldgktakmyrgGkicltihf 116
                 + l+f  +  yp  ++e+  +p      + +y +G+icl+i +
  EFC37650.1  50 YLLKFTFSNDYPLQSPEVVfVPPHVPLHEHVYTNGHICLNILY 92 
                 557888899****999976378888999***********9865 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.36
        UFC1  38 veenkesdndwfklesn..kegtkw 60 
                  +++k  dnd + +++    + t+w
  EFC37650.1 116 TQKKKPIDNDTYVMSCShsPKNTRW 140
                 4556666777776665411456666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (147 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       547  (0.0305092); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.48
# Mc/sec: 924.82
//
Query:       EFC37651.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.7e-32  110.4   0.0    1.1e-31  109.7   0.0    1.4  1  bVLRF1    bacteroidetes VLRF1 release factor
  ------ inclusion threshold ------
      0.037   13.3   1.6      0.054   12.7   1.6    1.2  1  SLAIN     SLAIN motif-containing family


Domain annotation for each model (and alignments):
>> bVLRF1  bacteroidetes VLRF1 release factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.7   0.0   1.3e-35   1.1e-31       2     148 ..      74     224 ..      73     225 .. 0.91

  Alignments for each domain:
  == domain 1  score: 109.7 bits;  conditional E-value: 1.3e-35
      bVLRF1   2 vllmlggGhfAgavvslkkkkeaevlahktfhrYttRrkqGgsQsandkakg.kaksaGaslRryneqalkedirellk.ewkeei.....ekselifi 93 
                 ++++++gGhf+ga+++    + ++ + hktf  Y+ R+kqGg+Q ++d ++g kaksaG+++Rr++e +++e+  ell+ +wk+++     +k+ + f+
  EFC37651.1  74 FVCIMHGGHFSGAIFD---PSLGKAIVHKTFSNYVSRKKQGGRQLQHDIQTGhKAKSAGSEIRRNQEVKFQEKLTELLTeTWKKYFdgegqQKVYCSFV 169
                 799*************...66899************************99998*************************978**9873322246677799 PP

      bVLRF1  94 rasgksnrkilfgyeeavlkkkdprlrsiPfttrrptlselkrvleeltrvkvse 148
                  ++g+ nr ++ +   + ++ k   +r+iPf++ +p++ +l  ++++l++v++++
  EFC37651.1 170 YCPGNINRDMIEQLLWNEMDLKSLPIRNIPFQVPKPNFMNLISCYDKLCTVHITS 224
                 9**********9988888999999***************************9975 PP

>> SLAIN  SLAIN motif-containing family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   1.6     6e-06     0.054     181     241 ..     245     305 ..     229     342 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 6e-06
       SLAIN 181 ldaysledeeeeydsl.pqprltrfsplqrglphsstfsSprdsrrs.rsPstsqeyssrlsq 241
                  d++s ed+ e++++   + +  +  p    +p+s tfsSp +s+rs  sP   q +  ++++
  EFC37651.1 245 SDEESSEDDLEKTKEQlLNDEYLKNYP-SPLSPQSATFSSPVHSPRSpLSPIL-QALGFNIEP 305
                 477888888777665545555444445.2369***************544444.333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       919  (0.0512577); expected 358.6 (0.02)
Passed bias filter:                      598  (0.0333538); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 2092.53
//
Query:       EFC37652.1  [L=352]
Description: Ser/Thr protein phosphatase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.6e-14   53.1   0.6    8.4e-14   52.5   0.6    1.3  1  Metallophos    Calcineurin-like phosphoesterase
    5.2e-11   43.0   0.0    1.6e-10   41.4   0.0    1.7  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.5   0.6   9.4e-18   8.4e-14       2     202 ..     139     319 ..     138     321 .. 0.66

  Alignments for each domain:
  == domain 1  score: 52.5 bits;  conditional E-value: 9.4e-18
                  EEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSSHHHHHHHHHHHHHHHH.TSEEEEEC-TTSCHHHHHHHHHHHHHHHHHHHEHH CS
  Metallophos   2 rilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrgdlekellellaalvky.pipvylllGNHegfeeellnkygylgifsepwrsd 98 
                  r++v++D+H      + +  l+l +      ++d++l++GD+++ g+  + + ++ ++l+    ++++++ GNHe  + + ++ky++l  +       
   EFC37652.1 139 RFVVTSDTH------NKHGMLNLPQ------EADVLLHCGDFTYAGSNAE-VSRFNDWLGTVnYKHKIVICGNHE--YPKTKEKYDELLSN--ATAVL 219
                  899******......7777777764......45*************4444.5555444444322344********..33555555554444..22222 PP

                  HCEEETSEEEEEETTEEEEEEEESECEEE...THHHHHHHHHHHSCHHHHCCHHHHHHHHHHTTCSEEEEEESSESS...CSSSCSCCHHHHHHHHHH CS
  Metallophos  99 aevfnnlplaslgsgslkvlllhGgspel...lvsldklgslnleleapepgdewlkdlekrekadwvivlgHsply...rgsgylfgdealedllkk 190
                  ++    +  + + ++   ++   G+++++   ++ ld+ g +++e + +   ++++         d++i+++H p++   +gsg++ ++   e+l++ 
   EFC37652.1 220 VNSSITIEGVKIFGT--PFVPNMGDFQGEnyfTKLLDNTGFYKKEEDLKSV-YDLIDT-------DTDILMTHTPPNkilDGSGKYGSYALKERLQYL 307
                  222222222223333..5666666633333334444444444444444444.777777.......9******************************** PP

                  TTESEEEEESSS CS
  Metallophos 191 ygvdlvisGHtH 202
                   ++++ ++GH+H
   EFC37652.1 308 TNLKVSCFGHVH 319
                  ************ PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.4   0.0   1.8e-14   1.6e-10       2     145 ..     139     337 ..     138     343 .. 0.72

  Alignments for each domain:
  == domain 1  score: 41.4 bits;  conditional E-value: 1.8e-14
  Metallophos_2   2 klaiiSDlHsnldaleavlealkevgvdaiihaGDl.eeeepevleellela......pvlaVrGNnD............................ 62 
                    ++++ SD+H        +l+  +e+  d ++h+GD+ ++++   + ++ + +        ++++GN++                            
     EFC37652.1 139 RFVVTSDTH----NKHGMLNLPQEA--DVLLHCGDFtYAGSNAEVSRFNDWLgtvnykHKIVICGNHEypktkekydellsnatavlvnssitieg 228
                    68999****....667778888889..*********9777776777777777777899999*********99999999999999999998888887 PP

  Metallophos_2  63 .................eevveedvlreaaelgtdl............peeaelel......agekvlliHgdpl........gvkdalaellkea 115
                                     e                              ++e++l+        ++++l++H  p+         +++al+e+l++ 
     EFC37652.1 229 vkifgtpfvpnmgdfqgE-----------------NyftklldntgfyKKEEDLKSvydlidTDTDILMTHTPPNkildgsgkYGSYALKERLQY- 306
                    777776666555444422.................0222223333333322222212344547777******999****9887555566666555. PP

  Metallophos_2 116 eegsdvvvcGHtHvp.evekeggvlvvnPGs 145
                      + +v ++GH H + + +k g++l++n+ s
     EFC37652.1 307 LTNLKVSCFGHVHGAyGYQKVGNTLFINASS 337
                    34446********99889999*******876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (352 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 2065.24
//
Query:       EFC37653.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.5e-14   52.0   0.0    5.9e-13   49.1   0.0    2.2  2  Glyco_hydro_108  Glycosyl hydrolase 108
    5.8e-06   26.5   0.6      1e-05   25.7   0.6    1.4  1  SH3_3            Bacterial SH3 domain
     0.0023   18.5   0.0     0.0048   17.5   0.0    1.6  1  SlpA             Surface later protein A domain
  ------ inclusion threshold ------
      0.082   12.9   0.0       0.12   12.4   0.0    1.3  1  DUF4858          Domain of unknown function (DUF4858)
       0.18   11.8   2.1       0.33   11.0   2.1    1.4  1  Sugarporin_N     Maltoporin periplasmic N-terminal extension


Domain annotation for each model (and alignments):
>> Glyco_hydro_108  Glycosyl hydrolase 108
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.34   1.2e+03      58      74 ..      55      71 ..      28      75 .. 0.77
   2 !   49.1   0.0   1.6e-16   5.9e-13       2      85 .]     141     248 ..     140     248 .. 0.96

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.34
                     HHTTCCCTGGGSSHHHH CS
  Glyco_hydro_108 58 edYwkklkldelpasva 74
                     e++w ++++ +++++++
       EFC37653.1 55 ESFWPETRCTNVDNALN 71
                     68*******99998776 PP

  == domain 2  score: 49.1 bits;  conditional E-value: 1.6e-16
                      HHHCHCCH-EEE-TCGGCG.......-EECTEEHHHCCCTT-BS.....................-CCCS-HHHHHHCHHHHTTCCCTGGGSSH CS
  Glyco_hydro_108   2 eevlahEGgyvndpkDkGG.......eTnkGItkktlralrkekaida.................dvkaltreeaaaiykedYwkklkldelpa 71 
                      +e++++EG+++n+++D+G+        T++G+t + + + r+    +                  +  +l +++aa++y e+Y+ + ++++lp+
       EFC37653.1 141 AEIFKSEGRCQNWASDSGNefqgkigYTCMGVTPSECWNNRNGFFAPFnngfsghpadfcyyaynQNPSLYKSSAAQLYSENYFGPGGCSNLPQ 234
                      689*************************************8888777799******************************************** PP

                      HHHHHHHHHHHHHB CS
  Glyco_hydro_108  72 svalvlfDaavnsG 85 
                      +  +v+ D+avnsG
       EFC37653.1 235 PAFYVCSDIAVNSG 248
                      *************9 PP

>> SH3_3  Bacterial SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   0.6   2.8e-09     1e-05       2      55 .]      69     118 ..      68     118 .. 0.91

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 2.8e-09
       SH3_3   2 glnvRsgPstssevigtlpyGekVevleetggge..WykvrtddgteGwvssgyls 55 
                 +lnvR++P+ +  v+ tl + ++V+v e ++ ++  W ++    g   wvs+++l+
  EFC37653.1  69 ALNVRTSPGGQ--VVKTLGPETQVTVYETSNVNGvkWARI----GDNQWVSAQFLK 118
                 79******999..***************99999999****....5556****9996 PP

>> SlpA  Surface later protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   1.4e-06    0.0048      15      54 ..      80     114 ..      72     115 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.4e-06
        SlpA  15 rvkktkklkkgssvktygkkvtIkNgkkYYkIgknqYika 54 
                  vk   +l   ++v++y+++ ++ Ng k  +Ig+nq++ a
  EFC37653.1  80 VVK---TLGPETQVTVYETS-NV-NGVKWARIGDNQWVSA 114
                 344...78889*********.9*.9*************87 PP

>> DUF4858  Domain of unknown function (DUF4858)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.3e-05      0.12      46     135 ..      62     149 ..      22     182 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.3e-05
     DUF4858  46 kwleldetlPealpkvskkkvvltlrPykantkynWdPvyqkk.ikvdkdtWrgdpfyelktlriysnwaknpldagvresleeieatglr 135
                 +  ++d++l    +  +  +vv tl P +  t y+   v   k  +++++ W + +f ++  +++ys    ++ d++  e+l ei  ++ r
  EFC37653.1  62 RCTNVDNALNV--RTSPGGQVVKTLGPETQVTVYETSNVNGVKwARIGDNQWVSAQFLKMACQESYSGPDSKTGDKAA-ETLAEIFKSEGR 149
                 34456666654..5556689*******************9755379*********************98877777764.566666555444 PP

>> Sugarporin_N  Maltoporin periplasmic N-terminal extension
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   2.1   9.1e-05      0.33       1      34 [.       1      33 [.       1      33 [. 0.69

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 9.1e-05
  Sugarporin_N  1 Mkkktlalaialllstaasv.aaaasltiEaRLaa 34
                  Mk +tl +a    l++ + v ++ ++l++E RLa+
    EFC37653.1  1 MKSSTLIVA--TVLFSVLLVaSSLNALSLERRLAK 33
                  555555555..555555555599**********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       576  (0.0321267); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1856.81
//
Query:       EFC37654.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00013   22.1   1.5    0.00057   20.1   1.5    2.2  1  BTB          BTB/POZ domain
    0.00033   21.2   0.0      0.001   19.6   0.0    1.9  2  RCC1         Regulator of chromosome condensation (RCC1) repe
  ------ inclusion threshold ------
      0.021   14.6   0.0        2.7    7.9   0.0    2.5  2  RCC1_2       Regulator of chromosome condensation (RCC1) repe


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   1.5   9.6e-08   0.00057       4     106 ..     294     412 ..     291     417 .. 0.66

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 9.6e-08
                 HHHHTTTS-EEEEETT..TEEEEE-HHHHHHH-HHHHHHHTST...........TTTTCCCE...EEEETTSGHH...HHHHHHHHHHHSEEEC-CGGG CS
         BTB   4 lresgelcDvtlvvgd..gkefkahkavLaarSpyFkalftsk...........eieessvs...eielddvepe...afealLefiYtgeleitseen 83 
                 l + ++ +D+ + +++  ++ ++ hk +L+ +S++++ lf+++           e     vs    i+l + +++   +++++ + +Y  e++  + ++
  EFC37654.1 294 LYNDESNSDIHVIINKdkNELLQLHKSILSVHSSVLNILFKNNennvvdlyefiE---MMVSdhwIIDLFNNSAKintILQIICKLCYGYEFNYLKLND 389
                 667788999999999888999**********************555555553331...22224334444343333333555555566777777767777 PP

                 HHHHHHHHHHHT-HHHHHHHHHH CS
         BTB  84 leelLaaadllqiprlkkaceef 106
                 l+ +L +a+ l+i  ++k+++ +
  EFC37654.1 390 LVGILIIAQQLDITWIVKHVCIL 412
                 77777777777777777766655 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.6   9.7e+03      37      48 ..       4      15 ..       3      16 .. 0.80
   2 !   19.6   0.0   1.7e-07     0.001       5      50 .]      24      71 ..      20      71 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.6
                EEEEEEETTEEE CS
        RCC1 37 vvkvacGddhtv 48
                ++ + +G +h+v
  EFC37654.1  4 IINMESGTFHSV 15
                667789****98 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 1.7e-07
                EEEE--GGGTTSSSS-.--E....EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1  5 ysWGrndyGqLGlgtt.esv....lvPtkveglsgnrvvkvacGddhtval 50
                ys+G+n++G LG  ++  ++     +P  ++     + ++++cG ++t+++
  EFC37654.1 24 YSFGSNEFGELGYANKsANElkliELPFTIKEG---DEIQICCGKNFTIFI 71
                9************88865554444459999664...679*********987 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.0   0.00044       2.7       5      29 ..       8      32 ..       4      33 .. 0.88
   2 ?    4.2   0.0    0.0066        40       2      18 ..      59      75 ..      59      77 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00044
      RCC1_2  5 saGdyHscaLtedGeVlcWGsNsdG 29
                 +G +Hs+  t d++ +++GsN++G
  EFC37654.1  8 ESGTFHSVLQTVDQKFYSFGSNEFG 32
                579999999999***********99 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0066
      RCC1_2  2 ksvsaGdyHscaLtedG 18
                +++++G +++++++e++
  EFC37654.1 59 IQICCGKNFTIFIHETD 75
                79***********9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1433  (0.0799264); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.47
# Mc/sec: 3160.28
//
Query:       EFC37655.1  [L=274]
Description: hypothetical protein NAEGRDRAFT_81883 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-06   26.6   0.3       0.57   10.8   0.0    3.7  4  RCC1      Regulator of chromosome condensation (RCC1) repeat
     0.0011   18.7   0.1        2.1    8.3   0.0    3.7  5  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
        1.6    8.9   5.9       0.61   10.2   1.1    2.2  2  DUF4852   Domain of unknown function (DUF4852)


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.3         3   1.8e+04       4       9 ..      34      39 ..      34      41 .. 0.64
   2 !   10.8   0.0   9.6e-05      0.57      13      50 .]      94     136 ..      90     136 .. 0.80
   3 !    9.2   0.0    0.0003       1.8       4      23 ..     142     161 ..     140     184 .. 0.80
   4 ?    2.3   0.0     0.043   2.6e+02       3      14 ..     196     207 ..     194     207 .. 0.88

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 3
                EEEEE- CS
        RCC1  4 VysWGr 9 
                Vy++G 
  EFC37655.1 34 VYGCGD 39
                677775 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 9.6e-05
                 GTTSSSS---E..EEEEE-GGGTTS...-EEEEEEETTEEEEE CS
        RCC1  13 GqLGlgttesv..lvPtkveglsgn...rvvkvacGddhtval 50 
                 + +G+ +  ++  ++Pt++++ + n   ++++ a G  h+v+l
  EFC37655.1  94 YKMGNCSFINNisNIPTLIKFNNLNtsdKIIDFAIGKEHVVFL 136
                 567787785555689****887766889************986 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.0003
                 EEEEE--GGGTTSSSS---E CS
        RCC1   4 VysWGrndyGqLGlgttesv 23 
                 +++ G+n++GqL +  ++s+
  EFC37655.1 142 IFGIGNNEHGQLAIIAKKSN 161
                 899*********88666544 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.043
                 EEEEEE--GGGT CS
        RCC1   3 rVysWGrndyGq 14 
                 ++y +G n+y q
  EFC37655.1 196 ELYVCGMNEYSQ 207
                 79*******987 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.39   2.3e+03      13      25 ..      25      39 ..      20      40 .. 0.64
   2 ?   -3.5   0.0       1.7     1e+04      13      21 ..      86      94 ..      85      94 .. 0.85
   3 !    8.3   0.0   0.00034       2.1       1      30 []     123     152 ..     123     152 .. 0.96
   4 !    5.5   0.0    0.0025        15      10      30 .]     186     207 ..     184     207 .. 0.86
   5 ?   -1.5   0.0      0.39   2.3e+03       1      14 [.     247     260 ..     247     263 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.39
      RCC1_2 13 aLtedGe..VlcWGs 25
                ++ ++    V+++G+
  EFC37655.1 25 GINSSKSqfVYGCGD 39
                555555566899997 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.7
      RCC1_2 13 aLtedGeVl 21
                +Lt+ G V+
  EFC37655.1 86 FLTRKGYVY 94
                79999*998 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00034
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +++ ++G  H ++L+  + +++ G+N++GQ
  EFC37655.1 123 IIDFAIGKEHVVFLSKLNSIFGIGNNEHGQ 152
                 68899************************9 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.0025
      RCC1_2  10 H.scaLtedGeVlcWGsNsdGQ 30 
                 H +++ t ++e++ +G N++ Q
  EFC37655.1 186 HlTFFTTFENELYVCGMNEYSQ 207
                 557888999*********9977 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 0.39
      RCC1_2   1 VksvsaGdyHscaL 14 
                 +k++ ++++ s+++
  EFC37655.1 247 IKDIKCNGRTSFII 260
                 79999*99999887 PP

>> DUF4852  Domain of unknown function (DUF4852)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.7     0.076   4.5e+02      37      95 ..      69     133 ..      42     180 .. 0.68
   2 ?   10.2   1.1    0.0001      0.61      58     110 ..     201     253 ..     149     256 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.076
     DUF4852  37 klekalrdvkleetFtillearlseYdfdkqkFeieplstgsskldarynnwsfPrsl.........k 95 
                  +++++ ++k++++  i l  +   Y ++   F i++ s+    +  ++nn++ ++++         +
  EFC37655.1  69 LINDKIIKFKSQDQLCIFLTRKGYVYKMGNCSF-INNISNIPTLI--KFNNLNTSDKIidfaigkehV 133
                 467778888888888888888888888998888.66665543333..688887777776666666653 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.0001
     DUF4852  58 rlseYdfdkqkFeieplstgsskldarynnwsfPrslklnfvnpesirdlpme 110
                  ++eY    q F ie   +g+ +++  ++  +f + +kl+ +n+e i+d++++
  EFC37655.1 201 GMNEYSQSFQPFVIESIVNGKLHVEDYFTLNNFMNVTKLVNKNIEDIKDIKCN 253
                 378999999********************99*******************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      236  (0.013163); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.23s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1881.61
//
Query:       EFC37656.1  [L=178]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.4e-63  212.8   0.1    2.7e-63  212.6   0.1    1.0  1  Arf        ADP-ribosylation factor family
    1.3e-13   50.9   0.0    1.5e-13   50.7   0.0    1.1  1  Ras        Ras family
    4.9e-12   46.1   0.1    6.8e-12   45.7   0.1    1.2  1  Roc        Ras of Complex, Roc, domain of DAPkinase
    6.9e-12   45.2   1.7      1e-08   34.7   0.2    2.3  2  G-alpha    G-protein alpha subunit
    1.5e-10   40.8   0.0    1.9e-10   40.5   0.0    1.1  1  SRPRB      Signal recognition particle receptor beta subunit
    1.2e-06   28.1   0.0    1.5e-06   27.7   0.0    1.2  1  Gtr1_RagA  Gtr1/RagA G protein conserved region
    0.00046   20.3   0.0    0.00071   19.6   0.0    1.3  1  MMR_HSR1   50S ribosome-binding GTPase


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  212.6   0.1     1e-66   2.7e-63       3     174 ..       7     177 ..       5     178 .] 0.96

  Alignments for each domain:
  == domain 1  score: 212.6 bits;  conditional E-value: 1e-66
                 HHHHGGTT..TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHH CS
         Arf   3 silaklklk.kkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleea 100
                 +++++l l  +k+++il+lGLD+aGKt  l+k++l+e v+t+PTigfn e +++k ++f+v+D+GGq+k+R lW++Y++ tdavif+vDs+dreR+ee 
  EFC37656.1   7 NMIKNLSLFeNKQAKILFLGLDAAGKTSTLYKIQLDENVDTIPTIGFNAEVIQYKRVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVDSNDRERFEEV 105
                 56666665449**************************************************************************************** PP

                 HHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 101 keeLkalleeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlses 174
                 +e L++++e+  l++++llv+aNKqD+p a + ++l+++l l+++k  ++++iq csa++g+gl egl+wls++
  EFC37656.1 106 SETLHKVMEDPSLSNAKLLVWANKQDIPRATNVTDLSKILRLNSIK--QDWYIQPCSAMNGTGLFEGLDWLSSK 177
                 **********************************************..9**********************976 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.7   0.0   5.7e-17   1.5e-13       1     126 [.      21     142 ..      21     177 .. 0.82

  Alignments for each domain:
  == domain 1  score: 50.7 bits;  conditional E-value: 5.7e-17
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++++G  a GKts l++   d+   + ++Tig++  +    ++ k+v+++++D  Gq++ ++l + yy+++++++ + d ++re fe+v++ ++++ +
  EFC37656.1  21 KILFLGLDAAGKTSTLYKIQLDENV-DTIPTIGFNAEV----IQYKRVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVDSNDRERFEEVSETLHKVME 114
                 899**************98888855.679***887654....66789********************************************99999998 PP

                 HST.TTSEEEEEEETTTGGGG-SS-HHH CS
         Ras 100 vae.envpivLvGnKvDleekravstee 126
                   + +n ++++ +nK D+ +  +v+  +
  EFC37656.1 115 DPSlSNAKLLVWANKQDIPRATNVTDLS 142
                 8888999***********9988876543 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.7   0.1   2.6e-15   6.8e-12       1     119 [.      21     131 ..      21     132 .. 0.76

  Alignments for each domain:
  == domain 1  score: 45.7 bits;  conditional E-value: 2.6e-15
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHH...HCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrss...enlk 96 
                 K++++G  ++GKts l +++ d+   ++ +tig +    +             k+v+++++D++Gq+++r+l ++y+++ +++i+++ds++    e+++
  EFC37656.1  21 KILFLGLDAAGKTSTLYKIQLDEN-VDTIPTIGFNAEVIQ------------YKRVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVDSNDRerfEEVS 106
                 99***************9997665.56799***9874322............35799******************************966550114555 PP

                 HHHHHHHHH..CSSS-EEEEEE-TT CS
         Roc  97 eWlkelkkv..agkspvilvgnkiD 119
                 e l+++ +    +++++++ +nk D
  EFC37656.1 107 ETLHKVMEDpsLSNAKLLVWANKQD 131
                 5444444432234667788889988 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.1   0.00016      0.41      19      45 ..      17      41 ..       3      47 .. 0.81
   2 !   34.7   0.2   4.1e-12     1e-08     186     281 ..      48     132 ..      43     136 .. 0.92

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00016
                XE..EEEEEEEESTTSSHHHHHHHHHH CS
     G-alpha 19 kkkrevkllllGqseSGKsTilkqlkl 45
                +  ++ k+l+lG +  GK+++l +++l
  EFC37656.1 17 N--KQAKILFLGLDAAGKTSTLYKIQL 41
                3..489*****************9995 PP

  == domain 2  score: 34.7 bits;  conditional E-value: 4.1e-12
                 ----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHH CS
     G-alpha 186 lktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDi 281
                 ++t+G++   ++++  ++fr++d+gGq + r  W ++++++da+iF+v           ++   r+ee  +  +++++ + l n+++++  nK Di
  EFC37656.1  48 IPTIGFNAEVIQYK-RVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVD----------SNDRERFEEVSETLHKVMEDPSLSNAKLLVWANKQDI 132
                 6899999999***9.********************************97..........4556899999999999999999999999999999998 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.5   0.0   7.2e-14   1.9e-10       2     128 ..      18     136 ..      17     148 .. 0.88

  Alignments for each domain:
  == domain 1  score: 40.5 bits;  conditional E-value: 7.2e-14
                 ---EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHH CS
       SRPRB   2 skpavllvGlsdsGKTslftrLttdsvkktvtSq.essaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEll 99 
                 ++ ++l++Gl  +GKTs + ++  d+  +t   +  +  + ++   k  ++++ D+ G++k+r+   +   + +   +++f+vDS  d  + +ev E l
  EFC37656.1  18 KQAKILFLGLDAAGKTSTLYKIQLDENVDTIPTIgFNAEVIQY---KRVQFRVFDIGGQDKIRTLWRH---YYNGTDAVIFIVDSN-DRERFEEVSETL 109
                 6889****************************99878888888...99***************85554...578899*******97.78889******* PP

                 HHHHHHHHHHTT---EEEEEE-TTSTT-- CS
       SRPRB 100 yeilliteklkdavdiliACnKqelflak 128
                  +++ +  +   + ++l+  nKq++  a 
  EFC37656.1 110 HKVMEDPSL--SNAKLLVWANKQDIPRAT 136
                 ****99984..456899*******98776 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.0   5.9e-10   1.5e-06       1     122 [.      21     131 ..      21     152 .. 0.82

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 5.9e-10
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletl 98 
                 k+L++G   +GKts    ++ +++  + +    ti  + + +  ++ +++ ++D+gGq+++ +        + ++  +++i+++D+++re +ee  etl
  EFC37656.1  21 KILFLGLDAAGKTST---LY-KIQLDENVDTIPTIGFNAEVI-QYKRVQFRVFDIGGQDKIRTLW-----RHYYNGTDAVIFIVDSNDRErFEEVSETL 109
                 89***********96...34.5666777777899*9999988.6899************987764.....789999***********997799999999 PP

   Gtr1_RagA  99 keilealrqyspeakvfvlihKmD 122
                 ++++e  +    +ak+ v  +K D
  EFC37656.1 110 HKVMEDPSL--SNAKLLVWANKQD 131
                 999987543..4566666666666 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   2.8e-07   0.00071       2     114 .]      22     129 ..      21     129 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 2.8e-07
                 EEEEESTTSSHHHHHHHH.HTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT.TTCSHHHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinal.tgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas.eeklkpldeel 97 
                 ++++G   +GK++ + ++ ++e++    +p  T+  n + +++k+ ++++ D+ G  +      +++  ++   + +d+++++vd++ +e ++++ e+l
  EFC37656.1  22 ILFLGLDAAGKTSTLYKIqLDENV--DTIP--TIGFNAEVIQYKRVQFRVFDIGG-QD------KIRTLWRHYYNgTDAVIFIVDSNdRERFEEVSETL 109
                 889999*****9999998344444..4444..444444444444668********.44......3444444444458********77756799999999 PP

                 HHHHHH...TTSEEEEEEES CS
    MMR_HSR1  98 eellee...akkplilvlnk 114
                 ++++e+   ++ +l++ +nk
  EFC37656.1 110 HKVMEDpslSNAKLLVWANK 129
                 99987677766667776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1085.69
//
Query:       EFC37657.1  [L=181]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.8e-18   66.7   6.6    3.7e-18   65.6   6.5    1.6  1  TRAP-gamma  Translocon-associated protein, gamma subunit (TRA
  ------ inclusion threshold ------
      0.023   14.7   0.0      0.046   13.8   0.0    1.5  1  UPF0154     Uncharacterised protein family (UPF0154)
        4.9    5.8   8.1        2.8    6.6   1.0    2.0  2  DUF2207     Predicted membrane protein (DUF2207)


Domain annotation for each model (and alignments):
>> TRAP-gamma  Translocon-associated protein, gamma subunit (TRAP-gamma)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.6   6.5   6.2e-22   3.7e-18      17     168 ..      32     176 ..      10     177 .. 0.82

  Alignments for each domain:
  == domain 1  score: 65.6 bits;  conditional E-value: 6.2e-22
  TRAP-gamma  17 ssalfyvnalivsaipiwlfwrihqmelle.slilfvivtllstyllalayknvkfvlkhkiavkReeavtrevnkkladdkKiskkekderilwkkne 114
                  + +fy+ al+ +++p +lf ++ ++e++  +++lf+iv+++s+y+l+ ay  ++   k+ i +   e +  + +         +kk+k+e +  kk++
  EFC37657.1  32 QNLFFYLVALVSTILPSYLFQGVLNLEFTGgTILLFLIVSCVSAYFLSKAYV-FNYLRKKPILTDNYEKIVTNAK------GSFNKKDKEE-AYAKKDK 122
                 567899*********************997255679***************6.4556666677666665544442......3356777776.67899** PP

  TRAP-gamma 115 vadyEsttfsifynNalflalllvlsfyllksfsptvnyilsvvvasglvalls 168
                 +a+  +t  ++f+ N++f al+l++sfy lk ++  +ny+ s++++s  v ++s
  EFC37657.1 123 LAELGATGHALFISNIIFFALVLFFSFYSLKRIDVRINYVASLLLSSFGVNYIS 176
                 ********************************************9997776665 PP

>> UPF0154  Uncharacterised protein family (UPF0154)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   7.6e-06     0.046       1      32 [.      64      95 ..      64     101 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 7.6e-06
     UPF0154  1 ivialivGlvlGffiarkymkkqlkenPpine 32
                i+++liv  v  +f+++ y+ ++l+++P ++ 
  EFC37657.1 64 ILLFLIVSCVSAYFLSKAYVFNYLRKKPILTD 95
                5799***********************98765 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   1.6    0.0037        22     369     432 ..      16      79 ..       3      99 .. 0.63
   2 ?    6.6   1.0   0.00046       2.8     353     407 ..      97     150 ..      78     176 .. 0.53

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0037
     DUF2207 369 rgyfdkkgkkklkklsalglgliilglilillallllvlllvfllilllillliaiivlllfsr 432
                  ++ ++++k ++  ++  +++++++++  il + l+ ++l+  +   +++l+li+++v ++f +
  EFC37657.1  16 TQLVREAKKDRTINFNQNLFFYLVALVSTILPSYLFQGVLNLEFTGGTILLFLIVSCVSAYFLS 79 
                 4566777777777777777777777777777776666655555555555555555555555433 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.00046
     DUF2207 353 fkkalkkwksavkk.kergyfdkkgkkklkklsalglgliilglilillallllvl 407
                 + k ++  k + +k ++++ + kk   kl++l+a g +l+i  +i++ l+l++ ++
  EFC37657.1  97 YEKIVTNAKGSFNKkDKEEAYAKK--DKLAELGATGHALFISNIIFFALVLFFSFY 150
                 222222222222223333444433..577777777777777777776666554333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       949  (0.052931); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1228.36
//
Query:       EFC37658.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.7    9.8   6.2       0.13   12.2   0.4    2.5  3  PDR_CDR   CDR ABC transporter
        3.4    7.2   6.9        2.5    7.6   3.2    2.2  2  DUF1700   Protein of unknown function (DUF1700)


Domain annotation for each model (and alignments):
>> PDR_CDR  CDR ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1       0.2   1.8e+03      43      63 ..       7      27 ..       4      39 .. 0.76
   2 ?   12.2   0.4   1.4e-05      0.13       9      74 ..      65     130 ..      59     140 .. 0.85
   3 ?   -0.7   0.1      0.15   1.4e+03      51      84 ..     142     175 ..     128     178 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.2
     PDR_CDR 43 sshlwrnfgiliaflifflal 63
                 +++ r +  l+ fl++f+ +
  EFC37658.1  7 DNERIRKYLTLFNFLMIFISC 27
                677788888899999999876 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 1.4e-05
     PDR_CDR   9 nvseenrvCavvGavpGqeyVsGddYlelsfgyssshlwrnfgiliaflifflalyllatelisae 74 
                 n+++  ++ ++    pG+ +V+  dY + +f+    +  r f il+a  + f+    + ++l + e
  EFC37658.1  65 NTTTMANITNTNSTSPGSIIVDSRDYTSIAFQTMFFDYMRCFFILLAVPATFIWYSYFSIDLQERE 130
                 56677778889999**************************************99888887776665 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.15
     PDR_CDR  51 giliaflifflalyllatelisaekskgevlvfk 84 
                 +i++ f i++ +  ++++ l++ + ++ + + f+
  EFC37658.1 142 IICLIFGIVWSISSIVLFVLVNGAYNNCKSKDFE 175
                 5666788888888888777777776666666555 PP

>> DUF1700  Protein of unknown function (DUF1700)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1     0.047   4.2e+02      88     103 ..      15      30 ..      13      38 .. 0.85
   2 ?    7.6   3.2   0.00028       2.5     105     171 ..     139     203 ..     137     210 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.047
     DUF1700  88 Lsllnlilvliplivi 103
                 L+l+n+++++i +i+ 
  EFC37658.1  15 LTLFNFLMIFISCIGH 30 
                 889*******999875 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00028
     DUF1700 105 slvlsllvvalallvsplvllvksllkgfeelslnvfvsigllglGllllivayylvkilykltvky 171
                 +l++ +l+++++  +s +vl v  + +++ +++++ f  i+ l+ Gll+l + +  + +   ++++y
  EFC37658.1 139 ALLIICLIFGIVWSISSIVLFV-LVNGAYNNCKSKDFERITGLSWGLLVLCILN-FTTWSLSILLQY 203
                 5789999*********999876.467889999999***********98665543.455666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1215  (0.0677673); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1632.34
//
Query:       EFC37659.1  [L=483]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.031   14.4   1.3      0.031   14.4   1.3    3.1  3  Oxidored_q5_N  NADH-ubiquinone oxidoreductase chain 4, amino 
      0.051   12.9   4.1       0.03   13.7   1.5    1.8  2  DUF3810        Protein of unknown function (DUF3810)
        1.5    9.1   6.9         12    6.2   0.4    2.7  2  Orf78          Orf78 (ac78)
        7.7    6.6  12.5         11    6.1   6.8    2.3  2  DHHC           DHHC palmitoyltransferase


Domain annotation for each model (and alignments):
>> Oxidored_q5_N  NADH-ubiquinone oxidoreductase chain 4, amino terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   1.5     0.082   3.7e+02      20      46 ..     231     258 ..     217     269 .. 0.62
   2 ?   14.4   1.3   6.9e-06     0.031      33      82 ..     299     348 ..     283     355 .. 0.77
   3 ?   -0.3   0.5      0.25   1.1e+03      27      47 ..     379     396 ..     356     415 .. 0.47

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.082
  Oxidored_q5_N  20 kkllwststlvslllallsll.llnlss 46 
                     ++l+ ++t+vs  +++++l  ll+ s+
     EFC37659.1 231 FSVLFLMTTCVSYAIFFTMLNrLLTDSN 258
                    2356667777888888777774444333 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 6.9e-06
  Oxidored_q5_N  33 llallsllllnlsssfslsnlsyllglDslSapLilLSlWllpLmilASq 82 
                     +a+   ++ +   ++++    y + +D++S+ L++LS+ +++++ +AS 
     EFC37659.1 299 AIAVPLAITWFGDFNSQVRDQAYDYFMDMFSFSLLILSFGISCIVAVASV 348
                    444444443345666777788899999*********************96 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.25
  Oxidored_q5_N  27 stlvslllallsllllnlsss 47 
                    + l ++++ +ls +   +++s
     EFC37659.1 379 LALAQVFIWVLSYI---CYYS 396
                    22222222222222...1122 PP

>> DUF3810  Protein of unknown function (DUF3810)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.26   1.1e+03     126     175 ..     194     248 ..     162     261 .. 0.53
   2 ?   13.7   1.5   6.8e-06      0.03      11      92 ..     319     404 ..     313     448 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.26
     DUF3810 126 eevrkeakkaykklgeeypllsgfypk...pKp..llfsellsylgitGyyfpft 175
                 +e+ +e+ +++k l  + +++s++  +   +++  ++fs l+ ++    y + ft
  EFC37659.1 194 KEIDHETLESLKDLFLDSEFYSYQKTTneaVRSmiSCFSVLFLMTTCVSYAIFFT 248
                 4455555555555544444443332111234441123444444444444444444 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 6.8e-06
     DUF3810  11 kilsrlsglfpFSvgellivllillvilylvlai.....klkkrkkkkkrllkvllrvllvllvvyflftllwglnYyreplserlg 92 
                 +++++++ +f+FS+  l   ++++++++++v+ +     +++ + ++ +  l+v+l+v++++l+ +f+ +l   + Yy +++++r+g
  EFC37659.1 319 QAYDYFMDMFSFSLLILSFGISCIVAVASVVIQFswhiaVYTDCSSNAQDKLNVVLTVFVLALAQVFIWVL-SYICYYSMTFHKRYG 404
                 56667777777777777666666666666665556666766778888888888888887777776666655.568999******996 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.4    0.0027        12      38      91 ..     196     253 ..     170     267 .. 0.58
   2 ?    5.2   1.4    0.0056        25      54      89 ..     364     399 ..     332     410 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0027
       Orf78  38 kekksaaeknditekesn.....aaekaqalnillisllavvcvlvll.....yviyYfvilre 91 
                  ++++ ++ +d              + ++++n  + s++++++vl l+     y+i++ ++ r 
  EFC37659.1 196 IDHETLESLKD------LfldseFYSYQKTTNEAVRSMISCFSVLFLMttcvsYAIFFTMLNRL 253
                 12222222222......13333345677777888889999999998887777799998887776 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0056
       Orf78  54 snaaekaqalnillisllavvcvlvllyviyYfvil 89 
                 sna+ k ++   +++ +la v + vl y+ yY +  
  EFC37659.1 364 SNAQDKLNVVLTVFVLALAQVFIWVLSYICYYSMTF 399
                 334556677777778888899999999**9997655 PP

>> DHHC  DHHC palmitoyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.3     0.018        80      95     119 ..     226     250 ..     186     268 .. 0.53
   2 ?    6.1   6.8    0.0024        11      46     119 ..     319     398 ..     312     405 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.018
        DHHC  95 lsilllvlsllfllllgllllfhly 119
                   i ++ + +l++  +++ ++f + 
  EFC37659.1 226 SMISCFSVLFLMTTCVSYAIFFTML 250
                 2233333333333333333333332 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0024
        DHHC  46 rNykyFl......lfllylllllilalvlllialvklveeekkseflavtllkkllsilllvlsllfllllgllllfhly 119
                 + y yF+      l++l++ +++i+a+   +i +++ +   +  + +a ++l+ +l++++l+l+ +f+ +l+++++++++
  EFC37659.1 319 QAYDYFMdmfsfsLLILSFGISCIVAVASVVIQFSWHIAVYTDCSSNAQDKLNVVLTVFVLALAQVFIWVLSYICYYSMT 398
                 55666654444448888888888888888888888888888888888888777788888888888888888888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1113  (0.0620782); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.45
# Mc/sec: 3204.74
//
Query:       EFC37660.1  [L=497]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.039   14.3   1.2        2.5    8.5   0.1    2.4  2  Comm      Commissureless
        0.1   13.1   3.1       0.42   11.1   0.2    3.0  3  DUF3899   Domain of unknown function (DUF3899)


Domain annotation for each model (and alignments):
>> Comm  Commissureless
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.1    0.0064        57      35      72 ..      32      69 ..      27      81 .. 0.91
   2 ?    8.5   0.1   0.00028       2.5      11      64 ..     371     430 ..     366     445 .. 0.60

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0064
        Comm 35 kfrtWkkkktardakstranssdtlveiereelpeyea 72
                ++++Wkk  ++ +  st+ ++++  v+ ++e+  +y++
  EFC37660.1 32 RYKKWKKVGKLIKFASTSFHNCHNFVQANVEKIRKYNT 69
                79*************************99999999986 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00028
        Comm  11 wigivltLlilslvFclcs....Cf...lyrkfrtWkkkktardakstranssdtlveier 64 
                 ++g+ +t ++ s++F+l+     Cf   + r+fr+ k+ ++ r+  s+++++++++++++ 
  EFC37660.1 371 MLGAFWTQVVGSILFMLFIpafgCFrilMNRQFRKAKN-QKKRKYYSYHNTKTHSIQNVNY 430
                 45555555555555544433334773335677777774.4445566677777788887665 PP

>> DUF3899  Domain of unknown function (DUF3899)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.3   1.2e+04      47      64 ..      25      42 ..       7      56 .. 0.60
   2 ?    0.9   0.1     0.076   6.8e+02      35      75 ..     183     225 ..     178     239 .. 0.43
   3 ?   11.1   0.2   4.7e-05      0.42      14      70 ..     380     434 ..     371     438 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.3
     DUF3899 47 ddsyyeykekkkesskks 64
                d s+y ++ kk +++ k 
  EFC37660.1 25 DTSDYAWRYKKWKKVGKL 42
                455555555544443333 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.076
     DUF3899  35 klkklflkkskkddsyyeykek..kkes....skkstrplliiGlll 75 
                 k+ ++      +++++ye  ek  k+++     k  t++  +++l +
  EFC37660.1 183 KFLTA----IREVEKKYETLEKdiKTNKkdfvQKRETSLVSWYNLAF 225
                 44444....23445555555554522223345333333333333333 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 4.7e-05
     DUF3899  14 igillivlnsGfFdgfsygfrklkklflkk.....skkddsyyeykekkkesskkstrplli 70 
                 +g +l++l   +F  f++ +++       +     ++k+++yy y   k++s+ ++ +  l+
  EFC37660.1 380 VGSILFMLFIPAFGCFRILMNR-------QfrkakNQKKRKYYSYHNTKTHSIQNVNYSVLF 434
                 4555555555555555555555.......444446***************998888777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (497 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1368  (0.076301); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 3349.65
//
Query:       EFC37661.1  [L=570]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.066   13.1   0.8        1.6    8.7   0.1    3.3  3  F-box     F-box domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.1   8.8e-05       1.6      22      40 ..      26      44 ..       4      51 .. 0.87
   2 ?   -3.3   0.0      0.53   9.5e+03      11      21 ..      80      90 ..      66      92 .. 0.86
   3 ?    0.7   0.0      0.03   5.3e+02      22      38 ..     149     165 ..     141     168 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 8.8e-05
                HHHHHCTT-HHHHHHHTTH CS
       F-box 22 dllalrrVSkgwrilidsd 40
                +l+a++ V+  wr+++++ 
  EFC37661.1 26 TLIAFAGVCSEWRRIVKES 44
                599*************975 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.53
                HHHHHHTS-HH CS
       F-box 11 lrhILerLpls 21
                l++I+++++ +
  EFC37661.1 80 LLQIFSQMEIR 90
                78999999876 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.03
                 HHHHHCTT-HHHHHHHT CS
       F-box  22 dllalrrVSkgwrilid 38 
                 ++ +lr  ++++ +l+d
  EFC37661.1 149 EVENLRTICTNLLNLTD 165
                 6889**********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (570 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       442  (0.0246528); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 3464.06
//
Query:       EFC37662.1  [L=235]
Description: hypothetical protein NAEGRDRAFT_81884 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       966  (0.0538792); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1506.30
//
Query:       EFC37663.1  [L=270]
Description: hypothetical protein NAEGRDRAFT_81885 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       309  (0.0172346); expected 358.6 (0.02)
Passed bias filter:                      240  (0.0133861); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1738.14
//
Query:       EFC37664.1  [L=685]
Description: hypothetical protein NAEGRDRAFT_81886 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (685 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       569  (0.0317363); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 4321.01
//
Query:       EFC37665.1  [L=2200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   4.3e-121  394.9 549.2    8.7e-06   26.0   4.4   37.2 37  EGF_2         EGF-like domain
    1.1e-23   82.0  14.6    1.1e-05   25.2   0.0    8.4  8  NHL           NHL repeat
    5.2e-06   26.6   6.6        4.8    7.5   0.0    6.4  6  Arylesterase  Arylesterase
    6.9e-05   22.9   0.0          6    7.1   0.0    4.6  4  Str_synth     Strictosidine synthase
     0.0048   17.2   2.2     0.0048   17.2   2.2   37.1 36  EGF           EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4  12.7   5.1e-06     0.018       4      32 .]     404     432 ..     402     432 .. 0.88
   2 !   16.2   7.0   2.9e-06      0.01       5      32 .]     445     471 ..     442     471 .. 0.92
   3 ?   -3.8   0.9         5   1.8e+04       7      15 ..     640     649 ..     639     656 .. 0.67
   4 !   16.1  11.9   2.9e-06      0.01       5      32 .]     662     688 ..     654     688 .. 0.91
   5 !   14.1  10.4   1.3e-05     0.047       7      32 .]     703     728 ..     693     728 .. 0.86
   6 !   15.3   9.9   5.5e-06      0.02       6      32 .]     742     767 ..     733     767 .. 0.88
   7 !   21.4   6.5   6.5e-08   0.00023       4      32 .]     779     806 ..     776     806 .. 0.91
   8 !   21.5   5.7   6.1e-08   0.00022       5      32 .]     820     846 ..     817     846 .. 0.92
   9 !   24.8   5.9     6e-09   2.1e-05       5      32 .]     859     885 ..     855     885 .. 0.91
  10 !   23.5   6.8   1.4e-08   5.2e-05       7      32 .]     900     924 ..     896     924 .. 0.94
  11 !   20.0   5.0   1.9e-07   0.00067       7      32 .]     949     973 ..     943     973 .. 0.92
  12 !   18.0   7.5   7.9e-07    0.0028       4      32 .]     985    1012 ..     982    1012 .. 0.90
  13 !   21.1   7.6   8.3e-08    0.0003       6      32 .]    1026    1051 ..    1022    1051 .. 0.91
  14 !   17.4   6.8   1.2e-06    0.0044       7      32 .]    1066    1090 ..    1062    1090 .. 0.94
  15 !   15.6   6.1   4.3e-06     0.015       7      32 .]    1105    1129 ..    1101    1129 .. 0.94
  16 !   15.3   6.9   5.3e-06     0.019       5      32 .]    1142    1168 ..    1138    1168 .. 0.91
  17 !   22.3   7.5   3.4e-08   0.00012       4      32 .]    1180    1207 ..    1178    1207 .. 0.93
  18 !   15.1   6.2   6.4e-06     0.023       6      32 .]    1221    1246 ..    1216    1246 .. 0.92
  19 !   15.0   7.4   6.9e-06     0.025       5      32 .]    1259    1285 ..    1256    1285 .. 0.91
  20 !   18.8   7.5   4.3e-07    0.0016       7      32 .]    1300    1324 ..    1296    1324 .. 0.93
  21 !   15.0   5.6   6.9e-06     0.025       7      32 .]    1339    1363 ..    1335    1363 .. 0.92
  22 !   22.0   7.1   4.2e-08   0.00015       4      32 .]    1375    1402 ..    1373    1402 .. 0.92
  23 !   26.0   4.4   2.4e-09   8.7e-06       7      32 .]    1417    1441 ..    1412    1441 .. 0.94
  24 !   14.5   7.0   9.6e-06     0.035       7      32 .]    1456    1480 ..    1451    1480 .. 0.92
  25 !   21.7   7.4   5.3e-08   0.00019       7      32 .]    1495    1519 ..    1491    1519 .. 0.93
  26 !   19.0   5.3   3.7e-07    0.0013       7      32 .]    1544    1568 ..    1539    1568 .. 0.93
  27 !   19.5   7.1   2.7e-07   0.00097       5      32 .]    1581    1607 ..    1578    1607 .. 0.88
  28 !    8.2   8.0   0.00091       3.2       5      32 .]    1620    1646 ..    1612    1646 .. 0.87
  29 !   15.6  10.7   4.3e-06     0.016       5      32 .]    1674    1700 ..    1671    1700 .. 0.91
  30 !   16.2  11.4   2.8e-06      0.01       5      32 .]    1713    1739 ..    1705    1739 .. 0.89
  31 !   17.3   6.1   1.2e-06    0.0045       5      32 .]    1752    1778 ..    1749    1778 .. 0.91
  32 !   26.0   9.0   2.5e-09   8.8e-06       1      32 []    1795    1825 ..    1795    1825 .. 0.92
  33 !   12.6   5.2   3.6e-05      0.13       7      32 .]    1840    1864 ..    1836    1864 .. 0.95
  34 !    8.3   6.1   0.00083         3       7      32 .]    1879    1902 ..    1875    1902 .. 0.79
  35 !   13.0   5.0   2.9e-05       0.1       6      32 .]    1916    1941 ..    1912    1941 .. 0.89
  36 !   12.4   4.8   4.4e-05      0.16       5      32 .]    1958    1984 ..    1954    1984 .. 0.88
  37 !    9.4   8.3   0.00038       1.4       5      32 .]    1997    2023 ..    1989    2023 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 5.1e-06
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+g+G+C+ ++ +C+C+s + G +C
  EFC37665.1 404 NsKSVCNGNGICNGFN-ECKCNSTWGGQYC 432
                 34889********777.9************ PP

  == domain 2  score: 16.2 bits;  conditional E-value: 2.9e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g G C +++  C+C+ g+ G +C
  EFC37665.1 445 KKVCNGVGNCTSPE-TCVCNYGWIGSYC 471
                 568********9**.9************ PP

  == domain 3  score: -3.8 bits;  conditional E-value: 5
       EGF_2   7 iCgg.hGtCv 15 
                 iC+g  G+C 
  EFC37665.1 640 ICQGyAGVCC 649
                 5888778884 PP

  == domain 4  score: 16.1 bits;  conditional E-value: 2.9e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G C +++  CdC+sg++G +C
  EFC37665.1 662 SSVCNGVGNCTSPE-TCDCESGFTGQYC 688
                 789********9**.9************ PP

  == domain 5  score: 14.1 bits;  conditional E-value: 1.3e-05
       EGF_2   7 iCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                  C++ +GtCv+    C+C++gy+G +C
  EFC37665.1 703 VCNNqNGTCVAND-TCVCNDGYSGYQC 728
                 69999****9555.8*********999 PP

  == domain 6  score: 15.3 bits;  conditional E-value: 5.5e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG C+++  +C+C sgy+G +C
  EFC37665.1 742 TVCNSHGLCISSD-NCVCTSGYFGTYC 767
                 67********888.7************ PP

  == domain 7  score: 21.4 bits;  conditional E-value: 6.5e-08
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C  hG+C ++   CdC+sgy+G+ C
  EFC37665.1 779 NSTVCTSHGICTSLD-TCDCQSGYYGPFC 806
                 5688*******9999.9************ PP

  == domain 8  score: 21.5 bits;  conditional E-value: 6.1e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C+++  +C+C+s ++G  C
  EFC37665.1 820 STVCSGNGICISPD-VCECNSTWSGEFC 846
                 678********999.************9 PP

  == domain 9  score: 24.8 bits;  conditional E-value: 6e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C ghG+C++++  C+C+s+++G  C
  EFC37665.1 859 TSVCAGHGKCISPN-ICECNSNWTGQFC 885
                 568********999.************9 PP

  == domain 10  score: 23.5 bits;  conditional E-value: 1.4e-08
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+G C+++  +C+C+s+++G++C
  EFC37665.1 900 VCNGNGECIQPD-ECFCNSNWTGPYC 924
                 6********888.9************ PP

  == domain 11  score: 20.0 bits;  conditional E-value: 1.9e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +C+g+G C+++  +C C+s+++G  C
  EFC37665.1 949 ACSGNGLCIRPD-ECLCNSNWTGQFC 973
                 7********999.9***********9 PP

  == domain 12  score: 18.0 bits;  conditional E-value: 7.9e-07
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C+g+G Cv ++  C+C+s y+G  C
  EFC37665.1  985 NESVCSGNGACVGPN-LCQCNSTYSGEFC 1012
                  4789********888.9***********9 PP

  == domain 13  score: 21.1 bits;  conditional E-value: 8.3e-08
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g+G Cv++  +C C+++++Gk C
  EFC37665.1 1026 SVCNGNGECVQPD-ECICNTNWTGKLC 1051
                  68********888.9************ PP

  == domain 14  score: 17.4 bits;  conditional E-value: 1.2e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G C+n++  C C+s + G+ C
  EFC37665.1 1066 VCSGNGECINPN-ICNCNSTWGGDLC 1090
                  6********999.************9 PP

  == domain 15  score: 15.6 bits;  conditional E-value: 4.3e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+++G C+++  +C C+ +++G  C
  EFC37665.1 1105 VCNNNGACIQPD-ECLCNYNWTGQFC 1129
                  6********888.9***********9 PP

  == domain 16  score: 15.3 bits;  conditional E-value: 5.3e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C+++  +C+C s + G  C
  EFC37665.1 1142 ETVCNGNGICIQPD-ECVCTSEWGGQFC 1168
                  678********888.9**********99 PP

  == domain 17  score: 22.3 bits;  conditional E-value: 3.4e-08
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +d+ C+ +G+C+n+  +C+C+s+++G  C
  EFC37665.1 1180 NDTVCNSNGICINPD-ECFCNSNWTGQFC 1207
                  5899********999.9***********9 PP

  == domain 18  score: 15.1 bits;  conditional E-value: 6.4e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g+GtC+++   C C s + G +C
  EFC37665.1 1221 LVCNGNGTCIQPD-ICNCTSEWGGQYC 1246
                  67********888.9************ PP

  == domain 19  score: 15.0 bits;  conditional E-value: 6.9e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C ghG C++++  C+C+s y G  C
  EFC37665.1 1259 ISVCEGHGNCISPN-ICECNSTYGGEFC 1285
                  578********999.***********99 PP

  == domain 20  score: 18.8 bits;  conditional E-value: 4.3e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G C+++  +C C+++++G  C
  EFC37665.1 1300 VCNGNGECIQPD-ECICNTNWTGQFC 1324
                  6********888.9***********9 PP

  == domain 21  score: 15.0 bits;  conditional E-value: 6.9e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G+Cv++   C+C+s + G  C
  EFC37665.1 1339 VCSGNGICVSPD-TCECNSTWGGYLC 1363
                  6********999.9*******99888 PP

  == domain 22  score: 22.0 bits;  conditional E-value: 4.2e-08
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C+ +G+C+n+  qC C+s+++G  C
  EFC37665.1 1375 NESVCNTNGICINPD-QCLCNSNWTGQFC 1402
                  4789********999.************9 PP

  == domain 23  score: 26.0 bits;  conditional E-value: 2.4e-09
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G+Cv+++  C+C+s+++G  C
  EFC37665.1 1417 VCSGNGQCVSPN-ICECNSSWSGELC 1441
                  7********999.***********99 PP

  == domain 24  score: 14.5 bits;  conditional E-value: 9.6e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G Cv +  +C+C+s + G +C
  EFC37665.1 1456 VCSGNGACVGPD-VCECNSTWGGQYC 1480
                  7********888.9************ PP

  == domain 25  score: 21.7 bits;  conditional E-value: 5.3e-08
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G C +++ +C C+s+++G+ C
  EFC37665.1 1495 VCNGNGECFQPN-ECICNSNWTGPFC 1519
                  6*******9788.9************ PP

  == domain 26  score: 19.0 bits;  conditional E-value: 3.7e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G C+++  +C C+s++ G +C
  EFC37665.1 1544 VCSGNGLCIRPD-ECLCNSNWAGQYC 1568
                  6********999.9************ PP

  == domain 27  score: 19.5 bits;  conditional E-value: 2.7e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+g+G+Cv+++ +C Cds+++   C
  EFC37665.1 1581 ETACNGNGKCVQPN-ECICDSNWTDQLC 1607
                  678********888.********98887 PP

  == domain 28  score: 8.2 bits;  conditional E-value: 0.00091
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+  G C+ ++  C C +g+ G +C
  EFC37665.1 1620 ISVCSRKGDCIGAN-LCICLTGWGGEDC 1646
                  678********666.8************ PP

  == domain 29  score: 15.6 bits;  conditional E-value: 4.3e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+ghG C +++ qC C+ ++ Gk+C
  EFC37665.1 1674 TLVCSGHGECTSPN-QCNCNLNWGGKQC 1700
                  578********999.************* PP

  == domain 30  score: 16.2 bits;  conditional E-value: 2.8e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ +G+Cvn++ qC+C+  + G  C
  EFC37665.1 1713 EAVCNSRGKCVNEN-QCQCNEMWGGQFC 1739
                  778*******9888.***********99 PP

  == domain 31  score: 17.3 bits;  conditional E-value: 1.2e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+  G+Cv ++ qC+C sg+ Gk C
  EFC37665.1 1752 SNVCNSLGVCVGPN-QCKCLSGWGGKLC 1778
                  689********888.************9 PP

  == domain 32  score: 26.0 bits;  conditional E-value: 2.5e-09
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C a +++C+g+G+C++++ +C+C+ g++G+ C
  EFC37665.1 1795 CIAKSNACSGNGKCIDLN-RCKCEKGWTGPLC 1825
                  6667899*******9999.************9 PP

  == domain 33  score: 12.6 bits;  conditional E-value: 3.6e-05
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g G+Cv++  +C C + + G  C
  EFC37665.1 1840 VCNGFGVCVAPD-KCNCYRDWGGEFC 1864
                  6********999.***********99 PP

  == domain 34  score: 8.3 bits;  conditional E-value: 0.00083
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+ +G+C++   +C+C+s + Gk C
  EFC37665.1 1879 VCNSRGICIEND-ECSCNS-WGGKLC 1902
                  6*******9555.8***85.777777 PP

  == domain 35  score: 13.0 bits;  conditional E-value: 2.9e-05
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+  G+Cv++  +C+C+sgy  + C
  EFC37665.1 1916 NVCNSSGVCVDFD-KCECFSGYGDAFC 1941
                  67********9*9.********77777 PP

  == domain 36  score: 12.4 bits;  conditional E-value: 4.4e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+g+G C  ++ +C C++++ G  C
  EFC37665.1 1958 GAVCSGRGLCLGPN-KCICQPNWGGFMC 1984
                  568********888.********99777 PP

  == domain 37  score: 9.4 bits;  conditional E-value: 0.00038
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +e C+ghG C++    C+C +gy   +C
  EFC37665.1 1997 KEVCSGHGDCIAVD-TCKCYQGYMDYDC 2023
                  789*******9667.8*******87766 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       3.4   1.2e+04      13      25 ..     126     138 ..     125     139 .. 0.82
   2 !   25.2   0.0     3e-09   1.1e-05       1      27 [.     178     204 ..     178     205 .. 0.95
   3 !   22.6   0.0   2.1e-08   7.4e-05       1      27 [.     234     260 ..     234     261 .. 0.95
   4 !   17.8   0.0   6.8e-07    0.0024       1      27 [.     290     316 ..     290     317 .. 0.93
   5 !   18.8   0.0   3.2e-07    0.0011       1      27 [.     347     374 ..     347     375 .. 0.95
   6 ?   -2.8   0.3       2.3   8.2e+03       1      13 [.     710     722 ..     710     722 .. 0.85
   7 ?   -2.4   0.1       1.7   6.3e+03       5      13 ..     747     755 ..     744     759 .. 0.82
   8 ?   -0.7   0.2      0.49   1.7e+03       6      18 ..    1336    1348 ..    1335    1348 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.4
                 TEEEEEECCCTEE CS
         NHL  13 GdiyVaDsenhrv 25 
                 +++y +D  nhr+
  EFC37665.1 126 NELYMTDVLNHRI 138
                 678889999***9 PP

  == domain 2  score: 25.2 bits;  conditional E-value: 3e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+G+++++nG+iy+aD+ nhr+++
  EFC37665.1 178 LNSPNGLSISQNGEIYIADTLNHRIRK 204
                 799**********************97 PP

  == domain 3  score: 22.6 bits;  conditional E-value: 2.1e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+Gv +++nG+iy+aD+ nhr+++
  EFC37665.1 234 LNSPNGVHISQNGEIYIADTLNHRIRK 260
                 799**********************97 PP

  == domain 4  score: 17.8 bits;  conditional E-value: 6.8e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P Gv v+++G+iy+aD+ nhr+++
  EFC37665.1 290 LNSPYGVHVSQSGEIYIADTLNHRIRK 316
                 68999********************97 PP

  == domain 5  score: 18.8 bits;  conditional E-value: 3.2e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P Gv v+ +n++i++aD+ n+r+++
  EFC37665.1 347 LNSPKGVFVSpNNNEILIADTSNNRIRK 374
                 799***********************97 PP

  == domain 6  score: -2.8 bits;  conditional E-value: 2.3
                 BSSEEEEEEETTT CS
         NHL   1 fnyPhGvavdsnG 13 
                 ++ +++++v+++G
  EFC37665.1 710 TCVANDTCVCNDG 722
                 578899***9987 PP

  == domain 7  score: -2.4 bits;  conditional E-value: 1.7
                 EEEEEETTT CS
         NHL   5 hGvavdsnG 13 
                 hG++++s++
  EFC37665.1 747 HGLCISSDN 755
                 9****9887 PP

  == domain 8  score: -0.7 bits;  conditional E-value: 0.49
                  EEEEETTTEEEEE CS
         NHL    6 GvavdsnGdiyVa 18  
                  +++v+s++ i+V+
  EFC37665.1 1336 DLSVCSGNGICVS 1348
                  899********95 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0032        11      51      78 ..     176     202 ..     166     207 .. 0.85
   2 !    7.5   0.0    0.0013       4.8      49      78 ..     230     258 ..     222     264 .. 0.86
   3 ?    2.9   0.0     0.035   1.2e+02      51      78 ..     288     314 ..     280     320 .. 0.85
   4 !    5.4   0.0    0.0058        21      49      78 ..     343     372 ..     335     376 .. 0.91
   5 ?   -3.1   0.0       2.6   9.4e+03      50      64 ..     819     833 ..     815     834 .. 0.83
   6 ?    0.7   0.4      0.17     6e+02      11      41 ..    2105    2135 ..    2103    2149 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0032
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   ++l+s+nG+ i+++   iy+ad l++ i
    EFC37665.1 176 AKLNSPNGLSISQNG-EIYIADTLNHRI 202
                   5799*******9877.59********98 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0013
  Arylesterase  49 vasglssanGInidadkkyiyvadilresi 78 
                   v s l+s+nG+ i+++   iy+ad l++ i
    EFC37665.1 230 VLSPLNSPNGVHISQNG-EIYIADTLNHRI 258
                   678899*******9877.59********98 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.035
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   s+l+s+ G+ +++    iy+ad l++ i
    EFC37665.1 288 SQLNSPYGVHVSQSG-EIYIADTLNHRI 314
                   68999******9876.59********98 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.0058
  Arylesterase  49 vasglssanGInidadkkyiyvadilresi 78 
                    as+l+s+ G+ +++++  i +ad  ++ i
    EFC37665.1 343 IASRLNSPKGVFVSPNNNEILIADTSNNRI 372
                   699*********************999887 PP

  == domain 5  score: -3.1 bits;  conditional E-value: 2.6
  Arylesterase  50 asglssanGInidad 64 
                    s + s nGI i++d
    EFC37665.1 819 NSTVCSGNGICISPD 833
                   578899*******97 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.17
  Arylesterase   11 fyatndhyFgdnfllllemslqlawtavvYy 41  
                    f + n   F +++l l+ + ++ +  av+Y+
    EFC37665.1 2105 FLISNAEKFINFILNLWTTFVEFIEWAVIYF 2135
                    67789999**********************9 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.039   1.4e+02      55      82 ..     177     203 ..     175     212 .. 0.79
   2 !    5.9   0.0    0.0038        14      52      87 ..     230     264 ..     225     266 .. 0.86
   3 ?    0.1   0.0      0.25     9e+02      54      88 ..     288     321 ..     284     322 .. 0.83
   4 !    7.1   0.0    0.0017         6      52      83 ..     343     374 ..     341     378 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.039
   Str_synth  55 kLyfanGialsedgsfvlvcetamkris 82 
                 kL  +nG+++s++g+  + ++t  +ri 
  EFC37665.1 177 KLNSPNGLSISQNGEIYI-ADTLNHRIR 203
                 7999*********99766.566666655 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0038
   Str_synth  52 lldkLyfanGialsedgsfvlvcetamkrisrywik 87 
                 +l+ L  +nG+ +s++g+  + ++t  +ri + +++
  EFC37665.1 230 VLSPLNSPNGVHISQNGEIYI-ADTLNHRIRKIFVN 264
                 578899***********9765.78999999998887 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.25
   Str_synth  54 dkLyfanGialsedgsfvlvcetamkrisrywike 88 
                 ++L  + G+ +s+ g+  + ++t  +ri + ++++
  EFC37665.1 288 SQLNSPYGVHVSQSGEIYI-ADTLNHRIRKIFVNG 321
                 7899999******999765.789999999999886 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0017
   Str_synth  52 lldkLyfanGialsedgsfvlvcetamkrisr 83 
                 ++++L  + G+ +s++++ +l+++t+ +ri +
  EFC37665.1 343 IASRLNSPKGVFVSPNNNEILIADTSNNRIRK 374
                 6899*************************876 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -6.8  10.3         5   1.8e+04       6      25 ..     409     424 ..     394     431 .. 0.78
   2 ?    0.2   3.0      0.28   9.9e+02       5      32 .]     446     470 ..     442     470 .. 0.86
   3 !    5.0   7.1    0.0085        31       6      31 ..     665     686 ..     654     687 .. 0.83
   4 !    6.9   2.4    0.0022         8       9      30 ..     708     725 ..     695     725 .. 0.88
   5 !   11.4   4.2   8.9e-05      0.32       5      31 ..     742     765 ..     737     766 .. 0.86
   6 !   10.3   5.9   0.00019      0.69       5      31 ..     779     804 ..     772     805 .. 0.82
   7 !    6.9   1.7    0.0021       7.6       4      31 ..     821     844 ..     817     845 .. 0.83
   8 !    5.5   5.4    0.0061        22       5      31 ..     858     883 ..     851     884 .. 0.81
   9 !    8.8   8.4   0.00056         2       4      32 .]     897     923 ..     890     923 .. 0.89
  10 !   10.1   1.8   0.00022       0.8       6      31 ..     950     971 ..     943     972 .. 0.87
  11 ?   -3.0   7.0       2.7   9.6e+03       5      31 ..     986    1010 ..     978    1011 .. 0.75
  12 !   10.1   6.8   0.00022       0.8       4      31 ..    1023    1049 ..    1017    1050 .. 0.89
  13 ?   -1.1   6.5      0.68   2.4e+03       6      25 ..    1067    1082 ..    1056    1089 .. 0.81
  14 !    7.1   5.3    0.0019       6.6       4      30 ..    1102    1126 ..    1095    1128 .. 0.84
  15 !    8.0   3.0     0.001       3.6       5      30 ..    1142    1165 ..    1137    1167 .. 0.85
  16 !   12.3   3.6   4.5e-05      0.16       5      31 ..    1182    1205 ..    1178    1206 .. 0.87
  17 !    9.5   2.9   0.00033       1.2       6      31 ..    1223    1244 ..    1215    1245 .. 0.86
  18 ?   -4.3   7.1         5   1.8e+04       4      31 ..    1257    1283 ..    1251    1284 .. 0.82
  19 !   10.0   6.4   0.00023      0.82       4      31 ..    1297    1322 ..    1290    1323 .. 0.87
  20 ?    2.0   7.3     0.075   2.7e+02       6      25 ..    1340    1355 ..    1329    1364 .. 0.79
  21 !   10.6   2.4   0.00015      0.55       5      31 ..    1376    1400 ..    1371    1401 .. 0.88
  22 ?    4.6   3.9     0.012        41       6      31 ..    1418    1439 ..    1407    1440 .. 0.88
  23 ?   -0.3   2.3       0.4   1.4e+03       6      25 ..    1457    1472 ..    1451    1479 .. 0.76
  24 !    7.5   7.1    0.0014       5.2       4      31 ..    1492    1517 ..    1485    1518 .. 0.85
  25 !    8.8   2.0   0.00055         2       6      31 ..    1545    1566 ..    1538    1567 .. 0.86
  26 !    8.5   3.4   0.00068       2.4       5      29 ..    1581    1603 ..    1578    1605 .. 0.86
  27 ?    0.4   2.0      0.24   8.7e+02      22      31 ..    1635    1644 ..    1622    1645 .. 0.87
  28 ?    3.6   5.1     0.023        82       4      31 ..    1672    1698 ..    1670    1699 .. 0.82
  29 ?    4.7   3.1     0.011        38       5      26 ..    1712    1732 ..    1709    1737 .. 0.83
  30 !    7.1   2.1    0.0019       6.8       3      31 ..    1752    1776 ..    1750    1777 .. 0.80
  31 !   17.2   2.2   1.3e-06    0.0048       3      31 ..    1799    1823 ..    1797    1824 .. 0.91
  32 ?    3.0   1.4     0.036   1.3e+02       5      31 ..    1839    1862 ..    1833    1863 .. 0.84
  33 ?    2.6   3.5      0.05   1.8e+02       4      24 ..    1876    1894 ..    1874    1896 .. 0.84
  34 !    8.8   1.6   0.00054       1.9       3      29 ..    1915    1937 ..    1912    1940 .. 0.86
  35 ?    2.3   3.5     0.062   2.2e+02       6      30 ..    1961    1981 ..    1955    1981 .. 0.85
  36 !    6.4   3.8    0.0032        12       6      28 ..    2000    2018 ..    1989    2020 .. 0.88

  Alignments for each domain:
  == domain 1  score: -6.8 bits;  conditional E-value: 5
                 STTT-EEEEETTTEEEEEEC CS
         EGF   6 CsngGtCvdtgrggytCiCp 25 
                 C+++G+C    +g  +C+C 
  EFC37665.1 409 CNGNGIC----NGFNECKCN 424
                 *******....777788886 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.28
                 T.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 + C++ G C +++    tC C  G+ G++
  EFC37665.1 446 KvCNGVGNCTSPE----TCVCNYGWIGSY 470
                 35999999*9999....********9975 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0085
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C++ G C +++    tC+C +G+tG 
  EFC37665.1 665 CNGVGNCTSPE----TCDCESGFTGQ 686
                 999999*9999....**********6 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0022
                 T-EEEEETTTEEEEEECTTEES CS
         EGF   9 gGtCvdtgrggytCiCpeGytG 30 
                 +GtCv +     tC C  Gy+G
  EFC37665.1 708 NGTCVAND----TCVCNDGYSG 725
                 799*****....********99 PP

  == domain 5  score: 11.4 bits;  conditional E-value: 8.9e-05
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + C+ +G C+++     +C C++Gy+G 
  EFC37665.1 742 TvCNSHGLCISSD----NCVCTSGYFGT 765
                 47*******9999....*********95 PP

  == domain 6  score: 10.3 bits;  conditional E-value: 0.00019
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                 +   C  +G+C ++     tC+C++Gy G+
  EFC37665.1 779 NstvCTSHGICTSLD----TCDCQSGYYGP 804
                 3446*******8888....*********97 PP

  == domain 7  score: 6.9 bits;  conditional E-value: 0.0021
                 TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytGk 31 
                 + Cs++G+C+++      C+C + ++G+
  EFC37665.1 821 TVCSGNGICISPD----VCECNSTWSGE 844
                 34**********9....****9877776 PP

  == domain 8  score: 5.5 bits;  conditional E-value: 0.0061
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                     C ++G+C+++     +C+C + +tG 
  EFC37665.1 858 DtsvCAGHGKCISPN----ICECNSNWTGQ 883
                 3578***********....*********95 PP

  == domain 9  score: 8.8 bits;  conditional E-value: 0.00056
                 TT..STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGkr 32 
                 +p  C+++G+C+++     +C+C + +tG++
  EFC37665.1 897 DPfvCNGNGECIQPD----ECFCNSNWTGPY 923
                 5788***********....**********86 PP

  == domain 10  score: 10.1 bits;  conditional E-value: 0.00022
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C+++     +C C + +tG 
  EFC37665.1 950 CSGNGLCIRPD----ECLCNSNWTGQ 971
                 ***********....*********95 PP

  == domain 11  score: -3.0 bits;  conditional E-value: 2.7
                  T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    5 p..CsngGtCvdtgrggytCiCpeGytGk 31  
                     Cs++G Cv +      C+C + y+G+
  EFC37665.1  986 EsvCSGNGACVGP----NLCQCNSTYSGE 1010
                  366*******433....379999888886 PP

  == domain 12  score: 10.1 bits;  conditional E-value: 0.00022
                  TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np...CsngGtCvdtgrggytCiCpeGytGk 31  
                  n+   C+++G+Cv++     +CiC + +tGk
  EFC37665.1 1023 NNysvCNGNGECVQPD----ECICNTNWTGK 1049
                  55678***********....**********8 PP

  == domain 13  score: -1.1 bits;  conditional E-value: 0.68
                  STTT-EEEEETTTEEEEEEC CS
         EGF    6 CsngGtCvdtgrggytCiCp 25  
                  Cs++G+C+++     +C C 
  EFC37665.1 1067 CSGNGECINPN----ICNCN 1082
                  ********999....99996 PP

  == domain 14  score: 7.1 bits;  conditional E-value: 0.0019
                  TT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF    4 np..CsngGtCvdtgrggytCiCpeGytG 30  
                  +p  C+n+G C+++     +C C   +tG
  EFC37665.1 1102 DPfvCNNNGACIQPD----ECLCNYNWTG 1126
                  6788***********....****988888 PP

  == domain 15  score: 8.0 bits;  conditional E-value: 0.001
                  T..STTT-EEEEETTTEEEEEECTTEES CS
         EGF    5 p..CsngGtCvdtgrggytCiCpeGytG 30  
                     C+++G+C+++     +C C++ + G
  EFC37665.1 1142 EtvCNGNGICIQPD----ECVCTSEWGG 1165
                  346***********....*****99988 PP

  == domain 16  score: 12.3 bits;  conditional E-value: 4.5e-05
                  T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    5 p.CsngGtCvdtgrggytCiCpeGytGk 31  
                  + C+ +G+C+++     +C+C + +tG 
  EFC37665.1 1182 TvCNSNGICINPD----ECFCNSNWTGQ 1205
                  36***********....*********95 PP

  == domain 17  score: 9.5 bits;  conditional E-value: 0.00033
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  C+++GtC+++     +C C++ + G 
  EFC37665.1 1223 CNGNGTCIQPD----ICNCTSEWGGQ 1244
                  ***********....*****999885 PP

  == domain 18  score: -4.3 bits;  conditional E-value: 5
                  TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np...CsngGtCvdtgrggytCiCpeGytGk 31  
                  n+   C ++G C+++     +C+C + y G+
  EFC37665.1 1257 NNisvCEGHGNCISPN----ICECNSTYGGE 1283
                  66777*******9999....9***8877665 PP

  == domain 19  score: 10.0 bits;  conditional E-value: 0.00023
                  TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np..CsngGtCvdtgrggytCiCpeGytGk 31  
                  +p  C+++G+C+++     +CiC + +tG 
  EFC37665.1 1297 DPyvCNGNGECIQPD----ECICNTNWTGQ 1322
                  5677***********....*********95 PP

  == domain 20  score: 2.0 bits;  conditional E-value: 0.075
                  STTT-EEEEETTTEEEEEEC CS
         EGF    6 CsngGtCvdtgrggytCiCp 25  
                  Cs++G+Cv++     tC+C 
  EFC37665.1 1340 CSGNGICVSPD----TCECN 1355
                  ***********....88875 PP

  == domain 21  score: 10.6 bits;  conditional E-value: 0.00015
                  T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    5 p..CsngGtCvdtgrggytCiCpeGytGk 31  
                     C+ +G+C+++     +C C + +tG 
  EFC37665.1 1376 EsvCNTNGICINPD----QCLCNSNWTGQ 1400
                  456***********....*********95 PP

  == domain 22  score: 4.6 bits;  conditional E-value: 0.012
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs++G Cv++     +C+C + ++G+
  EFC37665.1 1418 CSGNGQCVSPN----ICECNSSWSGE 1439
                  ***********....******99997 PP

  == domain 23  score: -0.3 bits;  conditional E-value: 0.4
                  STTT-EEEEETTTEEEEEEC CS
         EGF    6 CsngGtCvdtgrggytCiCp 25  
                  Cs++G Cv        C+C 
  EFC37665.1 1457 CSGNGACVG----PDVCECN 1472
                  *******54....4489996 PP

  == domain 24  score: 7.5 bits;  conditional E-value: 0.0014
                  TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np..CsngGtCvdtgrggytCiCpeGytGk 31  
                  +p  C+++G+C+++     +CiC + +tG+
  EFC37665.1 1492 DPyvCNGNGECFQPN----ECICNSNWTGP 1517
                  5677*******8888....9*********7 PP

  == domain 25  score: 8.8 bits;  conditional E-value: 0.00055
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs++G C+++     +C C + ++G 
  EFC37665.1 1545 CSGNGLCIRPD----ECLCNSNWAGQ 1566
                  ***********....********996 PP

  == domain 26  score: 8.5 bits;  conditional E-value: 0.00068
                  T..STTT-EEEEETTTEEEEEECTTEE CS
         EGF    5 p..CsngGtCvdtgrggytCiCpeGyt 29  
                     C+++G+Cv++     +CiC++ +t
  EFC37665.1 1581 EtaCNGNGKCVQPN----ECICDSNWT 1603
                  346**********9....******998 PP

  == domain 27  score: 0.4 bits;  conditional E-value: 0.24
                  EEECTTEEST CS
         EGF   22 CiCpeGytGk 31  
                  CiC +G+ G+
  EFC37665.1 1635 CICLTGWGGE 1644
                  ********98 PP

  == domain 28  score: 3.6 bits;  conditional E-value: 0.023
                  TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np...CsngGtCvdtgrggytCiCpeGytGk 31  
                  n+   Cs++G+C ++     +C C   + Gk
  EFC37665.1 1672 NNtlvCSGHGECTSPN----QCNCNLNWGGK 1698
                  44588*******6666....9****999998 PP

  == domain 29  score: 4.7 bits;  conditional E-value: 0.011
                  T...STTT-EEEEETTTEEEEEECT CS
         EGF    5 p...CsngGtCvdtgrggytCiCpe 26  
                  +   C+ +G+Cv+      +C+C e
  EFC37665.1 1712 NeavCNSRGKCVNEN----QCQCNE 1732
                  4577*******9999....9***75 PP

  == domain 30  score: 7.1 bits;  conditional E-value: 0.0019
                  STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGk 31  
                  +n C+  G Cv +     +C+C +G+ Gk
  EFC37665.1 1752 SNVCNSLGVCVGP----NQCKCLSGWGGK 1776
                  466*******433....47********98 PP

  == domain 31  score: 17.2 bits;  conditional E-value: 1.3e-06
                  STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGk 31  
                  +n Cs++G+C+d+     +C+C  G+tG+
  EFC37665.1 1799 SNACSGNGKCIDLN----RCKCEKGWTGP 1823
                  466***********....**********7 PP

  == domain 32  score: 3.0 bits;  conditional E-value: 0.036
                  T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    5 p.CsngGtCvdtgrggytCiCpeGytGk 31  
                  + C++ G Cv +     +C C   + G+
  EFC37665.1 1839 TvCNGFGVCVAPD----KCNCYRDWGGE 1862
                  45***********....****8877776 PP

  == domain 33  score: 2.6 bits;  conditional E-value: 0.05
                  TT..STTT-EEEEETTTEEEEEE CS
         EGF    4 np..CsngGtCvdtgrggytCiC 24  
                  +p  C+ +G+C+++     +C C
  EFC37665.1 1876 DPtvCNSRGICIEND----ECSC 1894
                  5667*******9999....9999 PP

  == domain 34  score: 8.8 bits;  conditional E-value: 0.00054
                  STTSTTT-EEEEETTTEEEEEECTTEE CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGyt 29  
                  pn C+  G Cvd      +C+C +Gy 
  EFC37665.1 1915 PNVCNSSGVCVDFD----KCECFSGYG 1937
                  455***********....*******96 PP

  == domain 35  score: 2.3 bits;  conditional E-value: 0.062
                  STTT-EEEEETTTEEEEEECTTEES CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytG 30  
                  Cs++G C     g  +CiC++ + G
  EFC37665.1 1961 CSGRGLC----LGPNKCICQPNWGG 1981
                  *******....57779*****9987 PP

  == domain 36  score: 6.4 bits;  conditional E-value: 0.0032
                  STTT-EEEEETTTEEEEEECTTE CS
         EGF    6 CsngGtCvdtgrggytCiCpeGy 28  
                  Cs++G C+ +     tC+C +Gy
  EFC37665.1 2000 CSGHGDCIAVD----TCKCYQGY 2018
                  ***********....*******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       837  (0.0466841); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.37u 0.34s 00:00:01.71 Elapsed: 00:00:00.53
# Mc/sec: 12455.25
//
Query:       EFC37666.1  [L=408]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-47  162.5   0.0    2.4e-47  162.1   0.0    1.0  1  ADP_ribosyl_GH  ADP-ribosylglycohydrolase
  ------ inclusion threshold ------
      0.028   15.2   0.2       0.22   12.3   0.0    2.4  2  RTTN_N          Rotatin, an armadillo repeat protein, centrio
      0.065   12.6   1.1      0.083   12.3   0.0    1.7  2  GpcrRhopsn4     Rhodopsin-like GPCR transmembrane domain


Domain annotation for each model (and alignments):
>> ADP_ribosyl_GH  ADP-ribosylglycohydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  162.1   0.0   4.1e-51   2.4e-47       3     283 ..      41     380 ..      40     386 .. 0.92

  Alignments for each domain:
  == domain 1  score: 162.1 bits;  conditional E-value: 4.1e-51
                     HHHHHHHHHHHGGGTT--HHHHHHHTSS--S-----STTTTTS-TT---HHHHHHHHHHHTEET..TEE-HHHHHHHHHH.HHT....T--SS-- CS
  ADP_ribosyl_GH   3 llGaavGDAlGlpvefwsydeirrrygelgetpdktgfghfglkpgewtddtqmallllesllea.ggldpedlarrflaeWleepgdteprgig 96 
                     ++G+++GD+lG   ef++++++++++++++  ++++ +++ ++k+ge tdd++mal++l+s+ e+  +++pe+++++fl+ Wl+    +ep ++g
      EFC37666.1  41 IFGLIIGDCLGSTSEFKHPNQVQNLIKSEKAGWPFELCANLTWKKGESTDDSDMALAILQSFHECnSQFNPEHVCDKFLE-WLN----KEPKDVG 130
                     79***************************9999********************************9889**********9.***....9****** PP

                     HHHHHHHHHTTTT-...-S-B..............---BTTTGGG-HHHHHHTSS-HHHHHHHHHHHHHTTB--HHHHHHHHHHHHHHHHHHTT- CS
  ADP_ribosyl_GH  97 nttrealrnlksgepppeagana...........ngsagngalmRaaplgllyagdpeeaaelaeeaarlTHnhpeavagaaayaaliaaalrgk 180
                      ttr++l   k+ ++  ++   +           +   +ngalmR  +++ll++ d  +++e+++ ++ +TH++ ea++ +++ + +i++al+ +
      EFC37666.1 131 FTTRKSLLYAKRAHSQSKENY-WscgslelfnenQSPPSNGALMRNGVIPLLSS-DISQILEWTILHSIITHYTFEAILPCIVHSIVIHRALESY 223
                     *******98888664444433.4588888****6666777*************9.**************************************** PP

                     -STHHHHHH..................................HHHHTTT-HHHHHHHGGGGG---HHH........HHHHH--SSBHHHHHHHH CS
  ADP_ribosyl_GH 181 sleealdaa................................eeelavapaeeelaaalrkalaladsdkdvdvdaeeavdelgsggyavealaaa 243
                      +++ l+                                  +e+ + +  ++ l+ + +k+l + ++ +   +++ ++++  + +g++v +l +a
      EFC37666.1 224 RNQKPLEIIttetvtnilcgktgewfnfkqlcnekkvhpiiLEWIKNNGGKKALEMEEKKVLGNLKEFE---TFNPYNFNYKNISGWSVLSLKIA 315
                     999999999999*******************99999999999999999999999999999999999999...99999999999************ PP

                     HHHHHH..........................-SSHHHHHHHHHTS-SSHHHHHHHHHHHHHHHH CS
  ADP_ribosyl_GH 244 lyallha.........................addfeeallaavnlGgDtdttgaiaGallGaly 283
                     l++l+h+                         +    e+++ +v  G D+dt gai+G+++G++y
      EFC37666.1 316 LWCLYHSakvdsvnfdrkvecppqlpswvfedQPRGFESVIFSVLTGADADTYGAITGCIMGVYY 380
                     ******988888888888888888888888774457889999**********************9 PP

>> RTTN_N  Rotatin, an armadillo repeat protein, centriole functioning
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.34     2e+03      25      43 ..     109     127 ..      97     168 .. 0.71
   2 ?   12.3   0.0   3.7e-05      0.22      36      79 ..     247     289 ..     217     295 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.34
      RTTN_N  25 vkekellkkLlewFnfepv 43 
                 ++++++  k lew n ep 
  EFC37666.1 109 FNPEHVCDKFLEWLNKEPK 127
                 7889999999999998874 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 3.7e-05
      RTTN_N  36 ewFnfepvpeeeevLaLllkllkspsaaellkkigavefLsklr 79 
                 ewFnf+++++e++v  ++l+ +k++ +++ l+ +  +++L +l+
  EFC37666.1 247 EWFNFKQLCNEKKVHPIILEWIKNNGGKKALE-MEEKKVLGNLK 289
                 8************************9998775.55566666655 PP

>> GpcrRhopsn4  Rhodopsin-like GPCR transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.2      0.53   3.1e+03     123     155 ..     191     223 ..     190     241 .. 0.55
   2 ?   12.3   0.0   1.4e-05     0.083     160     199 ..     291     330 ..     284     336 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.53
  GpcrRhopsn4 123 Wtitraklsslstvillvlivlivvlqvilvil 155
                  Wti  + +++  +  +l+ iv  +v++  l  +
   EFC37666.1 191 WTILHSIITHYTFEAILPCIVHSIVIHRALESY 223
                  555555555555555555555555555444433 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 1.4e-05
  GpcrRhopsn4 160 efdsaskihsyeslaGylllalrivlaiyFlyglrntikk 199
                  + + + ++++y+++ G+ +l l+i+l+++++ +  ++++ 
   EFC37666.1 291 FETFNPYNFNYKNISGWSVLSLKIALWCLYHSAKVDSVNF 330
                  6778999************************998887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (408 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       525  (0.0292822); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 2725.07
//
Query:       EFC37667.1  [L=409]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.8e-51  174.4  20.7    4.2e-51  173.9  20.7    1.2  1  CRT-like        CRT-like, chloroquine-resistance transporter-
    1.3e-07   31.4   9.8    1.3e-07   31.4   9.8    2.1  2  SLC35F          Solute carrier family 35
    8.6e-07   28.5  16.2    3.2e-05   23.3   8.9    2.2  2  UAA             UAA transporter family


Domain annotation for each model (and alignments):
>> CRT-like  CRT-like, chloroquine-resistance transporter-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  173.9  20.7   7.1e-55   4.2e-51      66     334 .]      87     354 ..      51     354 .. 0.90

  Alignments for each domain:
  == domain 1  score: 173.9 bits;  conditional E-value: 7.1e-55
    CRT-like  66 fpkrkFaimgaLDavsgilvvigavstsGslqvllnqaiipitllasllllkerysliqylGAlviilgvvvvlipsllg......essegnklvfnll 158
                   + k++im++LD  +  l+ i a ++sGsl ++l q++i i++++s+ +l++ry+++++ G l+++ g+++ l p  ++       ss++   ++ ll
  EFC37667.1  87 TSQIKYVIMAFLDNATNTLQTIPAAYVSGSLNTMLSQSVILINIIMSFTFLHTRYNTFHFSGVLLVLCGLIINLYPVFAQedassiASSSSMDWLWILL 185
                 45789***********************************************************************999865555556667789***** PP

    CRT-like 159 llisviPvalSnvykeiafkeveldvlyLqawvalfqlligilllpvnal.llkpakikfkeileslkdGlaCllgkntiveevlscgldeqkscDdCe 256
                 l +s+iP a+Snvyke  +k+ +ldv+ +++wv+++q+l+gi++     + +++ ++i+ +++ + +++G++C +g n+iv +         +s+D Ce
  EFC37667.1 186 LFCSNIPQAASNVYKEKCLKKEKLDVWLVNYWVSVWQVLFGIITSVFVFVpIPQTVSISWSDLNTYIWNGIKCSVGINSIVGG---------SSPDRCE 275
                 ******************************************97766666789999999*********************985.........689**** PP

    CRT-like 257 kawivvllyllvNiiyNilillvlkhagatvlsiastlrlPltnivfslkfivgkev.tplsaldvaglliillGlvlY 334
                 +  +v+ + +++N +y  l l+v +++++t+ +ia   rl l n++f lkfi+g++  ++ls+ dv++l+i+++G+v+Y
  EFC37667.1 276 SFPLVFWADIFFNFTYATLELYVFQYGSSTLAVIAAVSRLALSNLFFLLKFIAGEALeSQLSMFDVVSLVILVIGIVIY 354
                 ******************************************************8752689*****************9 PP

>> SLC35F  Solute carrier family 35
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   9.8   2.2e-11   1.3e-07      24     223 ..      32     246 ..      27     266 .. 0.65
   2 ?   -2.1   6.2      0.37   2.2e+03     236     299 .]     287     356 ..     275     356 .. 0.67

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 2.2e-11
      SLC35F  24 ltskylaekkinaPvlqtflnyvllalvytgillfrrgaekllei.....lk...rkwykylllalvdveanylvvkayqytsltsvqlldcfaipvvl 114
                  ts++ a+k++n P  ++     l++   t i+++ r+ + +l +     ++   +   ky+++a++d  +n l      y s    ++l   +i + +
  EFC37667.1  32 QTSSDEAQKDVNLPSKKSKWWRFLIVYALTCIMVIARSCDTVLYVrltyeIQnyiTSQIKYVIMAFLDNATNTLQTIPAAYVSGSLNTMLSQSVILINI 130
                 577788999999999998665555555567777777776665543222111111134679************9977666666655567788889999** PP

      SLC35F 115 vlswlflkvryrlvkiigvvvcilGvvllvvsdvlagrransgsnpvlGd....llvlaGatlyavsnvleeylvkklslvell..gllglfGaiisai 207
                 ++s+ fl++ry++ +++gv++ + G+++ ++  v+a + a+s       d    ll++      a snv+ e  +kk +l + l    ++++  ++ +i
  EFC37667.1 131 IMSFTFLHTRYNTFHFSGVLLVLCGLIINLYP-VFAQEDASSIASSSSMDwlwiLLLFCSNIPQAASNVYKEKCLKKEKLDVWLvnYWVSVWQVLFGII 228
                 *************************9987653.555444444333334441110344445555899******999976655544114577666666665 PP

      SLC35F 208 q.lail.erkelkaihWd 223
                   ++++    +  +i W+
  EFC37667.1 229 TsVFVFvPIPQTVSISWS 246
                 412222133455556665 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.37
      SLC35F 236 vlfllysllpilikktsatsvnls....lltsdlysll..iglflfhykvswlyllafvviliGlilysv 299
                   f++ +l   +++  s+t+  ++    l  s+l+ ll  i   + + ++s + ++++v+++iG+++ysv
  EFC37667.1 287 FNFTYATLELYVFQYGSSTLAVIAavsrLALSNLFFLLkfIAGEALESQLSMFDVVSLVILVIGIVIYSV 356
                 445555555567788888876554222233577777752255567889999999**************85 PP

>> UAA  UAA transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   8.9   5.3e-09   3.2e-05      59     180 ..      86     207 ..      49     266 .. 0.82
   2 !    9.6   0.8   8.1e-05      0.49      67     157 ..     283     378 ..     272     407 .. 0.68

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 5.3e-09
         UAA  59 kiPlktYvilvalffitsvlnnealkydisvPvhiifrssklipvmilGililgkrYsllqylsvllltlGviiftl..lsakdkkedskeslnkfllG 155
                  ++  +Yvi+++l  +t++l+    +y +s  + +++  s +++++i++  +l+ rY+ + ++ vll+  G+ii  +  + ++d ++ +++s +++l+ 
  EFC37667.1  86 ITSQIKYVIMAFLDNATNTLQTIPAAY-VSGSLNTMLSQSVILINIIMSFTFLHTRYNTFHFSGVLLVLCGLIINLYpvFAQEDASSIASSSSMDWLW- 182
                 455669*********************.*********************************************9987335555667777788887777. PP

         UAA 156 iallvlallldavlglvqeklykky 180
                 i+ll+ + + +a  ++++ek  kk 
  EFC37667.1 183 ILLLFCSNIPQAASNVYKEKCLKKE 207
                 9999****************99953 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 8.1e-05
         UAA  67 ilvalffitsvlnnealkydisvPvhiifrsskl.ipvmi.lGililg....krYsllqylsvllltlGviiftllsakdkkedskeslnkfllGia 157
                   ++++f+  +l+ ++++y  s ++ +i+  s l +++++ l ++i+g     + s+++++s+++l++G++i +  ++k+ +e+ +  + + ++ + 
  EFC37667.1 283 ADIFFNFTYATLELYVFQY-GSSTLAVIAAVSRLaLSNLFfLLKFIAGealeSQLSMFDVVSLVILVIGIVIYSVTEEKEANENDRIRKFQDSVSLS 378
                 5567888888888888888.788888887766653444431333444333337899*******************9998886665555555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1254  (0.0699426); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 2498.18
//
Query:       EFC37668.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0018   18.0   0.2     0.0035   17.1   0.2    1.5  1  DDE_3       DDE superfamily endonuclease
  ------ inclusion threshold ------
      0.052   13.1   0.3       0.11   12.1   0.3    1.5  1  zf-C2H2_12  Zinc-finger C2H2-type


Domain annotation for each model (and alignments):
>> DDE_3  DDE superfamily endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.2     4e-07    0.0035      56     136 ..      34     121 ..      15     128 .. 0.70

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 4e-07
       DDE_3  56 eetlnaedfaeflerlletalqak.........kivlilDnas.iHkseslrelveeeadrlellylPpySPelNpiEivwsklkrellk.r 136
                 ++++ +  f   +e++   a+++k         +++ i Dn +    ++ +++++ +    ++l+y+P yS  lN i+++ +++ r++ + +
  EFC37668.1  34 DKNMLEVFFNLTVEKVEAIAKRKKdlskknidaQLIAIKDNYKkDESCNVVQQVIWK---PIVLHYFPNYSQTLN-IKNWMHVMRRRVTHlQ 121
                 555555555555555555555555555666777788888888834445555666555...***************.79*******9998844 PP

>> zf-C2H2_12  Zinc-finger C2H2-type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.3   1.2e-05      0.11      24      49 ..     178     204 ..     173     211 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.2e-05
  zf-C2H2_12  24 vCmvCgeslasl.klstikrHIrqvHP 49 
                  C vC+e  +++ +++++k H++q H 
  EFC37668.1 178 YCKVCKENVYEVfSMNELKTHVEQNHC 204
                 6*****99987549************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1051  (0.0586201); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1647.81
//
Query:       EFC37669.1  [L=303]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-08   34.6   0.0    3.3e-08   33.8   0.0    1.3  1  RGS       Regulator of G protein signaling domain
     0.0022   17.7   0.1     0.0035   17.1   0.1    1.3  1  RGS-like  Regulator of G protein signalling-like domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.8   0.0   3.6e-12   3.3e-08       4      95 ..     184     278 ..     181     287 .. 0.78

  Alignments for each domain:
  == domain 1  score: 33.8 bits;  conditional E-value: 3.6e-12
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-H..HHHHHHHHHHCSS..STTTTTTHHHHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidk..klreelekrleke..qpsrklfeeaqe 95 
                  ll+d++  s+F +F ++++  e +  w ++++fkk  +++++k+ka ++++ y++ s+p eln+++   +r  l + +ek+  +   +lfe++++
  EFC37669.1 184 ILLKDPKTYSIFLDFARRSYTPEPVLCWTDIQKFKKL-PKKDRKEKALKMIDSYISLSAPLELNLPNinVMRRDLLNIIEKDetNIPIELFENVET 278
                 589999*******************************.**************************98621223333333333333355566666555 PP

>> RGS-like  Regulator of G protein signalling-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.1   3.9e-07    0.0035       4      81 ..     178     257 ..     175     293 .. 0.78

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3.9e-07
                 HHH-HHHHHH-HHHHHHHHHHHHHHS--HHHHHHHHHHHHTTS-TTHHHHHHHHHHHHHTSTT-TT-----HHHH..HHH CS
    RGS-like   4 pFqsleqlKsrPahLavflnyvlsqfdPsallfylitdlykqgtsKetrrvaleifstFleknallrvpvpesla..lel 81 
                 +F+  e l + P    +fl +      P ++l++   + +k+   K+ +  al + ++++  +a+l  + p+  +  ++l
  EFC37669.1 178 SFSTTEILLKDPKTYSIFLDFARRSYTPEPVLCWTDIQKFKKLPKKDRKEKALKMIDSYISLSAPLELNLPNINVmrRDL 257
                 577777776669999*************************************************9999988754400444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (303 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       790  (0.0440627); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.26s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1863.17
//
Query:       EFC37670.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.4e-33  113.9   0.3    1.3e-12   47.4   0.0    3.6  3  Mito_carr     Mitochondrial carrier protein
  ------ inclusion threshold ------
      0.029   14.6   6.5      0.047   13.9   0.0    2.7  3  Lys           C-type lysozyme/alpha-lactalbumin family
       0.07   13.3   1.6       0.38   10.9   0.2    2.5  3  dsRBD2        Double-stranded RNA binding domain 2
       0.38   11.3  17.5        0.2   12.2   7.4    2.3  2  Secretin_N_2  Secretin N-terminal domain


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.5   0.2   4.2e-14   1.9e-10       5      76 ..      12     113 ..       8     131 .. 0.78
   2 !   21.7   0.0   3.1e-08   0.00014      13      91 ..     135     237 ..     124     240 .. 0.83
   3 !   47.4   0.0   2.9e-16   1.3e-12       5      85 ..     253     334 ..     249     339 .. 0.87

  Alignments for each domain:
  == domain 1  score: 40.5 bits;  conditional E-value: 4.2e-14
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH......................CCCSSTTTSCSS..................HHHHHHHHHHHHHHHG CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqt......................qkksskksksaa..................ildvlkkiykeeGlrg 63 
                 +l+e l+G+++ +  +++  P+ ++++ lqt                      +          +                  ++d+  ki+k+eG+++
  EFC37670.1  12 ILSEQLIGLVSPISRAIISSPFNRIRIILQTqndiktttnttkqslsdpsslkS----------SssnntnntnnnntsnssnVIDCGIKIIKQEGILS 100
                 5677899************************66666666666666655555550..........0444555555566677788**************** PP

                 GGTTHHHHHHHHH CS
   Mito_carr  64 lyrGllpnllrva 76 
                 l++G++++l  v 
  EFC37670.1 101 LWKGFSAQLASVL 113
                 *******998765 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 3.1e-08
                 HHHHHHHHHHHHHHHHHHHHHHH.....................CCCSSTTTSCSS.............HHHHHHHHHHHHHHHGGGTTHHHHHHHHHH CS
   Mito_carr  13 glagavatlvttPldvvKtrlqt.....................qkksskksksaa.............ildvlkkiykeeGlrglyrGllpnllrvap 77 
                 +la ++++++ +Pl+  Kt l +                     +          +             ++d + k   e Gl + y G++  +l+  +
  EFC37670.1 135 LLASIINSIISYPLEQCKTILLVdehvhhlnyggannnnnknknD----------GnnnihnnekqysgVIDYFIKRSNESGLVSHYHGFITYILGGLI 223
                 6899*******************9999999999966555544440..........24455556666666****************************** PP

                 HHHHHHHHHHHHHH CS
   Mito_carr  78 asalkfvlyetlkr 91 
                 ++    ++y+ l++
  EFC37670.1 224 YRKSFSLIYQILRN 237
                 *9999999988765 PP

  == domain 3  score: 47.4 bits;  conditional E-value: 2.9e-16
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC.CSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqtqk.ksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvl 85 
                 v++e++ + l+ a a+ +++Pld++  rlq+q+ k+s+++k+++++++ kki++eeG+++ly+G+ + +l  ++ + + +vl
  EFC37670.1 253 VISEIILAQLCIASASALAYPLDTISRRLQLQAcKKSEDRKFTNTIQCAKKIIREEGVLALYQGYEAHCLSAFSLTLMSLVL 334
                 778999999999*******************8725567888888**************************999988888776 PP

>> Lys  C-type lysozyme/alpha-lactalbumin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.4     0.018        80      85     112 ..      79     107 ..      53     118 .. 0.71
   2 ?   -3.3   0.2       2.3     1e+04      38      54 ..     164     180 ..     148     190 .. 0.55
   3 ?   13.9   0.0     1e-05     0.047      79     116 ..     285     323 ..     277     328 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.018
                 SSSTHHHHHHHHHHHHHTCG.GGSHHHHH CS
         Lys  85 dddltddvkCakkildkkGi.daWvawkk 112
                 +++ ++ + C  ki++++Gi + W+ + +
  EFC37670.1  79 TSNSSNVIDCGIKIIKQEGIlSLWKGFSA 107
                 45667889999999999997467888765 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.3
                 TBTT-EEEETTSEEEET CS
         Lys  38 ydtkavvknangstdyG 54 
                 ++    ++n+n++++ G
  EFC37670.1 164 LNYGGANNNNNKNKNDG 180
                 34344444444444444 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 1e-05
                 BGGGGSSSSTHHHHHHHHHHHHHTCG.GGSHHHHHHSSS CS
         Lys  79 sCdklldddltddvkCakkildkkGi.daWvawkklCse 116
                 +C+k  d + t+ ++Cakki+ ++G+   ++ ++++C +
  EFC37670.1 285 ACKKSEDRKFTNTIQCAKKIIREEGVlALYQGYEAHCLS 323
                 589999999************999972568899999965 PP

>> dsRBD2  Double-stranded RNA binding domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.2   8.5e-05      0.38      55     112 ..      38      96 ..      21     106 .. 0.64
   2 ?   -0.3   0.0      0.24   1.1e+03      67     103 ..     158     192 ..     126     206 .. 0.52
   3 ?   -1.2   0.0      0.47   2.1e+03      24      68 ..     247     293 ..     240     315 .. 0.52

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8.5e-05
      dsRBD2  55 apvksssellrsakklkdseskekeeelengkeva.kekeesaesgssfrCevkilsks 112
                 + ++++++++++++ +k+s s+ ++ + +++++++ ++++++++s++   C +ki+ + 
  EFC37670.1  38 IILQTQNDIKTTTNTTKQSLSDPSSLKSSSSNNTNnTNNNNTSNSSNVIDCGIKIIKQE 96 
                 3556666666666666766666655555444444404445556678999******9763 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.24
      dsRBD2  67 akklkdseskekeeelengkevakekeesaesgssfr 103
                  +++++ +    ++  +n+k++++ +++ ++++++++
  EFC37670.1 158 DEHVHHLNYGGANN--NNNKNKNDGNNNIHNNEKQYS 192
                 33333333322222..333444444444444444444 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.47
      dsRBD2  24 ksnWrGsfPrelLcsfCrq..hrLsePvfsissapvksssellrsak 68 
                  s+W   +   +L ++C      L+ P+ +is     + ++ ++++k
  EFC37670.1 247 MSQWSIVISEIILAQLCIAsaSALAYPLDTISRRLQLQACKKSEDRK 293
                 56666666666666666431145666665555433333333333332 PP

>> Secretin_N_2  Secretin N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   7.4   4.5e-05       0.2       9      81 ..      40     113 ..      36     122 .. 0.59
   2 ?    4.4   2.4     0.013        57      25      45 ..     168     187 ..     161     208 .. 0.51

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 4.5e-05
  Secretin_N_2   9 lamkrsGlsntsvtsGsvsssgsssssssssssssgsssssssssnss...sgtkietesesdfwgeLqkalesml 81 
                   l+++++ + +t+ t  s s+ +s +ssss+++  ++++++++s+s++        i+ e   ++w+    +l+s+l
    EFC37670.1  40 LQTQNDIKTTTNTTKQSLSDPSSLKSSSSNNT--NNTNNNNTSNSSNVidcGIKIIKQEGILSLWKGFSAQLASVL 113
                   55666634444444444444444455555544..555555554444447744444566667789999988888877 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.013
  Secretin_N_2  25 svsssgsssssssssssssgs 45 
                   + ++++++++++++++  + +
    EFC37670.1 168 GANNNNNKNKNDGNNNIHN-N 187
                   3333333333333333221.1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1175  (0.0655363); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2074.55
//
Query:       EFC37671.1  [L=127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1275  (0.0711138); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 800.13
//
Query:       EFC37672.1  [L=699]
Description: Mx protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.2e-34  118.5   9.5    6.8e-34  117.4   9.5    1.6  1  Dynamin_M    Dynamin central region
    1.5e-29  103.3   0.3    1.5e-29  103.3   0.3    2.6  2  Dynamin_N    Dynamin family
    6.3e-08   32.7   0.2    8.5e-07   29.1   0.0    2.9  3  MMR_HSR1     50S ribosome-binding GTPase
     0.0005   20.5   0.6      0.089   13.2   0.0    3.4  3  AAA_16       AAA ATPase domain
    0.00092   18.7   0.1     0.0046   16.4   0.0    2.2  3  TniB         Bacterial TniB protein
  ------ inclusion threshold ------
      0.019   14.1   0.3      0.066   12.3   0.3    1.9  1  DUF3086      Protein of unknown function (DUF3086)
        0.1   13.0   1.8        2.1    8.8   1.0    2.6  2  ComGG        ComG operon protein 7
       0.13   12.2   1.1       0.51   10.3   0.1    2.6  2  Toprim_Crpt  C-terminal repeat of topoisomerase
        0.8   10.0   8.4         13    6.1   0.5    4.4  4  FliS         Flagellar protein FliS


Domain annotation for each model (and alignments):
>> Dynamin_M  Dynamin central region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.4   9.5   3.4e-37   6.8e-34       6     284 ..     247     541 ..     242     542 .. 0.88

  Alignments for each domain:
  == domain 1  score: 117.4 bits;  conditional E-value: 3.4e-37
   Dynamin_M   6 enkvipLklGYvgVvnRsqkdInkkksieealkkEkaFFeshpayrkladkaGtpyLakkLnqiLvehIrkslPelkkkineklqklekeleelgeskp 104
                 ++ +i+L +G+v+ +nR++++  k++siee+ k E+++++s +a    +++ G ++L++kL+qi+ eh ++s+P+ k+ ++++l k+e++le+++++++
  EFC37672.1 247 NEGSISLLHGFVALKNRTSDE--KHLSIEECEKIESSLLDSLDAP---DGSKGRAALIEKLTQIQNEHLQESIPKQKELLQQELIKIESQLENTSNNIQ 340
                 55689************8888..*******************887...9**********************************************9999 PP

   Dynamin_M 105 sde.........ektklllqlitkfkedfkkli....eGe....se..vs.tkelsggarireiFne....tlekslekidpleelsdeeirtairnsr 179
                 + +         ++++ + +l+++fk+   ++     + +    ++   s   +ls++++++e ++e    +l++s ++i+++     e i+++i++++
  EFC37672.1 341 QFYaygdealirSYETSISSLVSAFKDISVNTEildmS-SsedlKKsvTSnPLSLSVFSSVTEALSEeiltILTSSKTQINNYF----EAITKFIDKTS 434
                 88777777788888999999999999988887655431.123431233233555*************66655557777777777....8********** PP

   Dynamin_M 180 G.relplfvpekaFealvkkqikkleepalkcvelVyeelekivek.lekelkrFpnLreeikevvedllreqeeptkemienliemelayintnhpdf 276
                 G + lp +++++++ +l++ +++++++++ k+v +++e++++++ k l ++    ++L++++k+ +++++++  ++tk++i+++++ e++ ++t+++++
  EFC37672.1 435 GfPGLPDLYQPTILLKLANLEMANVRKVVDKYVLEAWERVKRMLLKhLVPKQIGSSKLEKMLKTELKQHYDSVFKTTKKIIDKVFRREIQRTFTMDKSY 533
                 *9*******************************************988886667899****************************************** PP

   Dynamin_M 277 igalkair 284
                 + +++ ir
  EFC37672.1 534 AVRSQLIR 541
                 **999887 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.3   0.3   7.3e-33   1.5e-29       1     168 []      48     228 ..      48     228 .. 0.88
   2 ?   -1.7   0.5       1.3   2.6e+03      79      79 ..     339     339 ..     292     405 .. 0.52

  Alignments for each domain:
  == domain 1  score: 103.3 bits;  conditional E-value: 7.3e-33
                 EEEEEBTTTTHHHHHHHHHTS--S---SSS---S-EEEEECCT---C....CS...SSEEEE.......T-EB--CHHHHHHHHHHHHHHHTSSSS--S CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlgedilprgpnptTrrplelqlgeeeeas....eravkeelkek.......ekkledfsevreeieketekiagankgisk 88 
                 i+vvG+qS+GKSSvl+ L g + +++g+ ++Tr+pl+l+++++  ++     +++k             + + ed  ++ +   +   +++  n+++ +
  EFC37672.1  48 IVVVGEQSAGKSSVLEYLSGVK-FVTGQDMVTRCPLQLRMNHSYGEEakaiVKSAK-----IespieipNPESEDGAKLLDDTIRNITQLHIGNETVAN 140
                 89********************.7****************8887755333333333.....23456689777778777777777777777779****** PP

                 S-EEEEEEETTS-SEEEEE---B-SSSGTTS........HHHHHHHSTTEEEEEEEETTS-CCC-CHHHHHHHHSTTBTTEEEEEE-C CS
   Dynamin_N  89 kvillkilsllvkgltlvDlPGldsvnkrdq........elvkeyikkadiilavtsanhdlsnsealflarevdpkgkrtivvltkl 168
                 ++i +++ s++v++ltlvDlPGl+    +d         elv++ ++++d il v +   dl +      a+evd+++krt++vltk+
  EFC37672.1 141 ELIEVQVISPHVPDLTLVDLPGLITKSSKDNpylaenirELVRKNMTEKDCILIVGDGGRDLQTIVGFTEAEEVDKDQKRTLCVLTKV 228
                 ******************************9********************************999999*****************96 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.3
                 H CS
   Dynamin_N  79 i 79 
                 i
  EFC37672.1 339 I 339
                 2 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.1   0.0   4.3e-10   8.5e-07       1     113 [.      47     226 ..      47     228 .. 0.76
   2 ?   -1.7   0.0       1.5     3e+03      13      49 ..     537     573 ..     536     618 .. 0.67
   3 ?   -1.8   0.0       1.6   3.2e+03      37      84 ..     639     693 ..     630     696 .. 0.52

  Alignments for each domain:
  == domain 1  score: 29.1 bits;  conditional E-value: 4.3e-10
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEE.................................................... CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgke.................................................... 47 
                 ++++vG   +GKS+++  l+g +  v+ +  +Tr + + r++++  e                                                    
  EFC37672.1  47 NIVVVGEQSAGKSSVLEYLSG-VKFVTGQDMVTRCPLQLRMNHSYGEeakaivksakiespieipnpesedgakllddtirnitqlhignetvanelie 144
                 589*****************9.566889999**********9554224677888888899999999999999999999999****************** PP

                 ..........EEEEECGGCSSHHHHHH.HHHHHHHHHHC.....TSEEEEEEETTTTCSHHHH..HHHHHHHHHTTSEEEEEEE CS
    MMR_HSR1  48 ..........ielvDtpGliegaseek.glgkaflalee.....adlillvvdaseeklkpld..eeleelleeakkplilvln 113
                           ++lvD+pGli ++s+++  l++++++l +      d il+v d   ++l+ +    e ee+  +++k+++ vl+
  EFC37672.1 145 vqvisphvpdLTLVDLPGLITKSSKDNpYLAENIRELVRknmteKDCILIVGDGG-RDLQTIVgfTEAEEVD-KDQKRTLCVLT 226
                 ******************9986777777666666663322332269999999955.3233332222333332.24455666666 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.5
                 HHHHHHHHTST.EEESSSTTSSSSEEEEEEEETTEEEE CS
    MMR_HSR1  13 StLinaltgek.aivsdkpgtTrdinegrvklkgkeie 49 
                 S Li++l++ k  + +++   T++ +  ++ +++ +i+
  EFC37672.1 537 SQLIRQLCKLKgKQQESYEAETLKEQLSQFGYSD-DIT 573
                 7899999987515668888888888887777544.433 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.6
                 EEEEEEETTEEEEEEECGGC.....S...SHHHHHH.HHHHHHHHHHCTSEEEEEEE CS
    MMR_HSR1  37 negrvklkgkeielvDtpGl.....i...egaseek.glgkaflaleeadlillvvd 84 
                 n +rv+  + +ie + +pG+     i   + +++e  + +k +++++ ++ ++ v+d
  EFC37672.1 639 NNKRVS--NFPIEPIELPGVpiqriIdvmKPSKSELdSYRKLLEKHQAVKKAIEVID 693
                 555555..6778888999964344323222222222233333333444566666666 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.0   4.4e-05     0.089      11      44 ..      32      65 ..      26     128 .. 0.86
   2 ?   -0.5   0.2      0.71   1.4e+03     107     107 ..     309     309 ..     210     434 .. 0.62
   3 ?    3.4   0.1     0.044        88      70     117 ..     528     600 ..     484     622 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.4e-05
      AAA_16 11 qLlsalervrsgrpelvllsGesGvGKsslvrel 44
                +L s+l++  + rp++++++Ge+  GKss+++ l
  EFC37672.1 32 ELSSILQNFEDLRPPNIVVVGEQSAGKSSVLEYL 65
                55666666666789*****************876 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.71
      AAA_16 107 a 107
                  
  EFC37672.1 309 H 309
                 1 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.044
      AAA_16  70 salaqalareellrqlldeaesaeleawrekleeala.................avpelagaea..........s 117
                  +  +++ r++l+rql+  + +++ ++ +e+l+e+l+                 ++++ +   +          s
  EFC37672.1 528 TMDKSYAVRSQLIRQLCKLKGKQQESYEAETLKEQLSqfgysdditfvsylqdlPAKSSKQ--SaaievlikfkS 600
                 3344455577888888888888888899999998888888888888888776442222222..222223333331 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   2.3e-06    0.0046      15      54 ..      25      64 ..      16      90 .. 0.90
   2 ?   -2.5   0.0       1.4   2.8e+03      25      51 ..     180     205 ..     174     252 .. 0.52
   3 ?   -3.5   0.0       2.9   5.9e+03     144     157 ..     240     253 ..     231     260 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.3e-06
        TniB 15 rakeilerLeeLleypkrkrmpnlllvGdsnnGKtmivek 54
                + +ei ++L ++l++ +  r+pn+++vG++  GK++++e 
  EFC37672.1 25 KYREINDELSSILQNFEDLRPPNIVVVGEQSAGKSSVLEY 64
                668999******************************9985 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.4
        TniB  25 eLleypkrkrmpnlllvGdsnnGKtmi 51 
                 eL+++   ++  ++l+vGd      +i
  EFC37672.1 180 ELVRKNMTEK-DCILIVGDGGRDLQTI 205
                 5555554444.6777777765443333 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 2.9
        TniB 144 nalksLgnelkipi 157
                  ++ksL+ne +i++
  EFC37672.1 240 KLIKSLKNEGSISL 253
                 67999999999997 PP

>> DUF3086  Protein of unknown function (DUF3086)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.3   3.3e-05     0.066       7     134 ..     313     450 ..     306     473 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.3e-05
     DUF3086   7 eleerkqalqieveqLerrkeriekelrtsfaGvsqdlairvqgfkdyLvgslqdLaaaaeqlelvakekav...kpePadekeeeekeeeeeaepq.. 100
                 ++ ++k+ lq+e+ ++e + e+  +++++ +a   ++l +  ++    Lv++++d+++++e l++ ++e  +   +++P++ +  ++ +e+ ++e    
  EFC37672.1 313 SIPKQKELLQQELIKIESQLENTSNNIQQFYAYGDEALIRSYETSISSLVSAFKDISVNTEILDMSSSEDLKksvTSNPLSLSVFSSVTEALSEEILti 411
                 466789999***********************9999**999*************************998776444667773333222222222221123 PP

     DUF3086 101 ..faeqefkeeakkirklldq...yrekPdyygppWqlr 134
                    ++++ ++  + i k +d+   +   Pd y p+  l+
  EFC37672.1 412 ltSSKTQINNYFEAITKFIDKtsgFPGLPDLYQPTILLK 450
                 334444555555666666655333677888888877665 PP

>> ComGG  ComG operon protein 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.16   3.2e+02      32      66 ..     241     273 ..     232     282 .. 0.81
   2 ?    8.8   1.0     0.001       2.1       3      43 ..     303     342 ..     302     359 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.16
       ComGG  32 laeteeeqqegtlsfeeGkvtYkitdedetkvkvs 66 
                 l +  +  +eg++s  +G v++k +++de+++++ 
  EFC37672.1 241 LIKSLK--NEGSISLLHGFVALKNRTSDEKHLSIE 273
                 444444..69******************9999985 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.001
       ComGG   3 tekkfaeetkeiykqdeLlqngvlevkrhlaeteeeqqegt 43 
                 t+++  +++++i kq eLlq+ +++++++l++t ++  +++
  EFC37672.1 303 TQIQNEHLQESIPKQKELLQQELIKIESQLENTSNN-IQQF 342
                 67788899*************************998.4444 PP

>> Toprim_Crpt  C-terminal repeat of topoisomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       2.8   5.5e+03      18      30 ..     176     188 ..     174     189 .. 0.85
   2 ?   10.3   0.1   0.00026      0.51       6      39 ..     228     261 ..     226     276 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.8
  Toprim_Crpt  18 eevkeLltkgktg 30 
                  e+++eL++k  t+
   EFC37672.1 176 ENIRELVRKNMTE 188
                  799*****99986 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00026
  Toprim_Crpt   6 igktiagkklseeevkeLltkgktgllkGFksKk 39 
                  + k i +k++ ++ +k+L ++g ++ll+GF+  k
   EFC37672.1 228 VDKCINDKEIRQKLIKSLKNEGSISLLHGFVALK 261
                  6688999***********************9544 PP

>> FliS  Flagellar protein FliS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.4   2.8e+03      41      63 ..      16      38 ..       6      43 .. 0.68
   2 ?    6.1   0.5    0.0063        13      16      98 ..     240     322 ..     235     339 .. 0.71
   3 ?    1.7   0.1      0.14   2.9e+02      39      77 ..     579     616 ..     575     624 .. 0.84
   4 ?    3.3   0.0     0.047        93      23      58 ..     659     695 ..     649     697 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.4
                HHHHHHHHHHHHHHHHHHHHTCC CS
        FliS 41 iekkgeaiskaqdIiseLrasLd 63
                + k + + +k  +I +eL++ L+
  EFC37672.1 16 MSKLHAQSNKYREINDELSSILQ 38
                56677777888888888887773 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0063
                 HHHHHHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHHHHHTCCTTTSCHHHHHHHHHHHHHHHHHHHHHHCT-HHHHH CS
        FliS  16 klvlmLydgalkflkrakeaieekdiekkgeaiskaqdIiseLrasLdlekggeiaknLaalYdyiirrlleanlkkdaekld 98 
                 kl+  L ++   +l +   a++++  ++k+ +i+ + +I s L +sLd  +g +  + L +  + i+++ l+ ++ k++e l+
  EFC37672.1 240 KLIKSLKNEGSISLLHGFVALKNRTSDEKHLSIEECEKIESSLLDSLDAPDGSKGRAALIEKLTQIQNEHLQESIPKQKELLQ 322
                 5666666666666667778999999***********************98886665555555555555555555555555544 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.14
                 TTHHHHHHHHHHHHHHHHHHHHTCCTTTSCHHHHHHHHH CS
        FliS  39 kdiekkgeaiskaqdIiseLrasLdlekggeiaknLaal 77 
                 +d+ +k+ + s a++++ ++++ L+  +   ia++ +++
  EFC37672.1 579 QDLPAKSSKQSAAIEVLIKFKSYLNIAAT-RIADQVSQI 616
                 57788999999***************986.999999874 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.047
                 HHHHHHHHHHHHHHH.TTTHHHHHHHHHHHHHHHHHH CS
        FliS  23 dgalkflkrakeaie.ekdiekkgeaiskaqdIiseL 58 
                 +++++ +k  k  ++  +++ +k++a++ka+++i+ L
  EFC37672.1 659 QRIIDVMKPSKSELDsYRKLLEKHQAVKKAIEVIDRL 695
                 5666667777777762345999************988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (699 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1298  (0.0723967); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.80u 0.31s 00:00:01.11 Elapsed: 00:00:00.49
# Mc/sec: 4250.21
//
Query:       EFC37673.1  [L=1646]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.8e-28   96.2   3.1    3.2e-27   94.6   3.1    2.0  1  GSAP-16        gamma-Secretase-activating protein C-term
    3.1e-06   26.6   0.0    5.4e-06   25.9   0.0    1.3  1  Hydrolase_4    Serine aminopeptidase, S33
    5.4e-06   27.2   0.0    8.6e-06   26.5   0.0    1.3  1  Abhydrolase_6  Alpha/beta hydrolase family
  ------ inclusion threshold ------
      0.084   13.0   0.1       0.34   11.1   0.1    2.0  1  PPIP5K2_N      Diphosphoinositol pentakisphosphate kinase 2 N
      0.087   12.4   0.0       0.32   10.6   0.0    1.9  2  Abhydrolase_1  alpha/beta hydrolase fold


Domain annotation for each model (and alignments):
>> GSAP-16  gamma-Secretase-activating protein C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.6   3.1   8.8e-31   3.2e-27       2     108 .]    1351    1461 ..    1350    1461 .. 0.95

  Alignments for each domain:
  == domain 1  score: 94.6 bits;  conditional E-value: 8.8e-31
     GSAP-16    2 elsrallellwkkagl.dpllelidelksseelal..FhllerllealeelafPlPpgFhslftvLGvrcLplstflqYidngvleltedvvkkllk 95  
                  +ls++l+++l++++++ +++  ++++ k++e++ +  Fhll++l+ +lee++fP P+gF ++f+++Gv++Lpl++++qYi+++++++t++v+++++k
  EFC37673.1 1351 QLSQYLFTTLTQILHTfHQKQRHFNQGKCTEVYPMwyFHLLQKLHVSLEETNFPSPSGFLEHFATVGVHVLPLNNLIQYINREMFIVTDNVIHEVMK 1447
                  89**********9988788899************999************************************************************ PP

     GSAP-16   96 d.lddteenekkkf 108 
                  + +++t+e+ekk++
  EFC37673.1 1448 KsQQQTSEKEKKAW 1461
                  97888889988876 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.0   1.5e-09   5.4e-06       4     102 ..     179     285 ..     176     323 .. 0.84

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 1.5e-09
  Hydrolase_4   4 kavvvlvHGlaehsgryae..laeaLaaqGfavyalDhrGhGrse.......gkrghvpsfddyvdDlaafvekvk.eehpelplfllGhSmGGlial 91 
                   + ++++HG+      ya    a  L ++G++ + +D r hG s+       g  g+ +   d++  l+ +++++   + ++  + l+G SmGG++a+
   EFC37673.1 179 SKFIIVIHGIRTCRFTYASlePASMLYRKGYNLLLIDLRNHGDSDdydknpyGSFGYYE-HRDVLGALDYLTKRFTfLDTQTPDVSLFGSSMGGATAI 275
                  567999****999999998446999************************9999999655.5788999999999998667777799************* PP

  Hydrolase_4  92 lyllrypdkva 102
                    ++++++ ++
   EFC37673.1 276 VTFAKEKR-FK 285
                  99988877.55 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.5   0.0   2.4e-09   8.6e-06       1      81 [.     182     276 ..     182     389 .. 0.62

  Alignments for each domain:
  == domain 1  score: 26.5 bits;  conditional E-value: 2.4e-09
                    EEEE--GC.....G..C.HHHHHHHHCCTCEEEEE--TTSTS-GGCS........--HHHCHHHHHHHCCTT.........TTSEEEEEETCHHHH CS
  Abhydrolase_6   1 vlllHGagssassW..l.vapLaallaagvhvlapDlpGhGrsdppp........ldledladlaalldelaa.......gggpvvlvGHSlGGal 78 
                    ++++HG  + +  +  l  a++  l+++g+  l +Dl++hG+s  ++        +++ + +d++ +ld l +       ++++v l+G S+GGa 
     EFC37673.1 182 IIVIHGIRTCRFTYasLePASM--LYRKGYNLLLIDLRNHGDS--DDydknpygsFGYYEHRDVLGALDYLTKrftfldtQTPDVSLFGSSMGGAT 273
                    7899**9987777743244455..45555666*********44..441244444444444477744444444444489889*************95 PP

                    HHH CS
  Abhydrolase_6  79 ala 81 
                    a  
     EFC37673.1 274 AIV 276
                    443 PP

>> PPIP5K2_N  Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   9.5e-05      0.34       9      60 ..    1457    1510 ..    1453    1515 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 9.5e-05
   PPIP5K2_N    9 ekkakskpmkeilerlekfeelevvifee..evileepveeWPlcdvlisfysk 60  
                  ekka ++ m++++++l++ e+ +v+ +e   +++l++p +e  + ++li +y++
  EFC37673.1 1457 EKKAWCSLMRSLIQKLKDRENRDVFHYERmlSCMLNQPSSENTVQNILINYYHS 1510
                  79*************************974469******************985 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   8.9e-05      0.32       4     106 ..     183     292 ..     180     307 .. 0.68
   2 ?   -2.6   0.0      0.94   3.4e+03     204     236 ..     351     378 ..     340     390 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 8.9e-05
                    EEE-STTTCGGGGTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB.CHHSHHHHHHHHH...HH.....HHHCTTSSEEEEEETHHHHHHHHHH CS
  Abhydrolase_1   4 vilhGlpgssdvwaerglapaLakdgfdvillDlrGvgySspapacinddygtasvaddld...ri.....ldalgddkltlvGhSmGGmialaya 91 
                    +++hG+  +   +a +  a+ L ++g+ ++l+Dlr++g S+     +   +g   ++d+l    ++        +    + l G SmGG++a   +
     EFC37673.1 183 IVIHGIRTCRFTYASLEPASMLYRKGYNLLLIDLRNHGDSDDYDKNPYGSFGYYEHRDVLGaldYLtkrftFLDTQTPDVSLFGSSMGGATAIVTF 278
                    6666666655555554445567888*******************98886665555555555333333322434445555668**********9999 PP

                    HHHGGGEEEEEEESE CS
  Abhydrolase_1  92 aeyperVkalvllga 106
                    a+  +r k l +++a
     EFC37673.1 279 AK-EKRFKLLFTDSA 292
                    98.666776666666 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.94
                    HHCTHHHHSEEEEEEETTCSSSCH.HHHHHHHHC CS
  Abhydrolase_1 204 lrelknvlaptlvisgtsDplvpp.kaledlaql 236
                     ++       +++++++ D++vp+ +++ + +++
     EFC37673.1 351 GDR------RVFFFQTSGDWIVPDyNMQICVDAA 378
                    555......8999***********8888777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1646 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1485  (0.0828267); expected 358.6 (0.02)
Passed bias filter:                      618  (0.0344693); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.11u 0.32s 00:00:01.43 Elapsed: 00:00:00.52
# Mc/sec: 9440.79
//
Query:       EFC37674.1  [L=682]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   1.2e-128  428.8   0.0   1.7e-128  428.3   0.0    1.2  1  Transketolase_N  Transketolase, thiamine diphosphate binding 
    7.3e-42  143.0   0.0    1.3e-41  142.2   0.0    1.4  1  Transket_pyr     Transketolase, pyrimidine binding domain
    3.9e-09   36.5   0.0    7.4e-09   35.5   0.0    1.5  1  Transketolase_C  Transketolase, C-terminal domain
     0.0019   17.5   0.0     0.0034   16.6   0.0    1.4  1  DXP_synthase_N   1-deoxy-D-xylulose-5-phosphate synthase
     0.0095   16.0   0.0       0.37   10.9   0.0    2.4  2  DUF498           Protein of unknown function (DUF498/DUF598)
  ------ inclusion threshold ------
       0.11   11.4   0.0       0.26   10.2   0.0    1.6  2  E1_dh            Dehydrogenase E1 component


Domain annotation for each model (and alignments):
>> Transketolase_N  Transketolase, thiamine diphosphate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  428.3   0.0  5.7e-132  1.7e-128       4     332 ..      12     341 ..       9     343 .. 0.98

  Alignments for each domain:
  == domain 1  score: 428.3 bits;  conditional E-value: 5.7e-132
                      HHHHHHHHHHHHHHHHHT-S--HHHHHHHHHHHHHHHHT--B-TTBTT-TTS-EEEESSGGGHHHHHHHHHHTTS.S--HHHHTTTTSTT-SS- CS
  Transketolase_N   4 kavnaiRvLavDavekaksGhPGaplgladiaevlfkkllkhnPndpkwidRDRfvLsnGhaslllYsllhLtGy.dlsledlksfrqlgsktp 96 
                       av ++R L+ D+vekaksGhPG+p+g+  ia vl+k++ +   +dp+wi+RDRf+LsnGh+++l+Y+llhLtGy ++++e+l+++r+l+s+tp
       EFC37674.1  12 IAVGTLRCLTADMVEKAKSGHPGMPIGMSTIAFVLWKYFYRASGKDPTWINRDRFILSNGHGCALQYALLHLTGYeSMPMEQLQKLRTLDSNTP 105
                      57899**********************************************************************99***************** PP

                      SS--TTTSTT--S---STTHHHHHHHHHHHHHHHHHHHH-BTTB-S----EEEEEEHHHHHSHHHHHHHHHHHHTT-TTEEEEEEESSEETTEE CS
  Transketolase_N  97 GhPelghtagvevttGPLGqGianavglalaektlaatynkpgfdivdhytyvilgDgclmeGvsseasslagtlkLgkLivlyDdnkisidGe 190
                      GhPe +ht+gv++ttGPLGqG++n++g+a+ae +l  ++n+++ +++dhytyv++gDg+lmeG+s+e +s+ag+++L+k+iv+yDdn+i+idG+
       EFC37674.1 106 GHPEWFHTDGVDATTGPLGQGMCNSIGMAVAECHLSKRFNRNELKLFDHYTYVFCGDGDLMEGMSTEGMSFAGHQQLNKVIVFYDDNRITIDGS 199
                      ********************************************************************************************** PP

                      GGGT--S-HHHHHHHTT-EEEEE.TTTT-HHHHHHHHHHHHH-TTS-EEEEEE--TTTTSTTTTTSGGGTSS---HHHHHHHHHHTTS-TT-TS CS
  Transketolase_N 191 teisftedvakrfeaygWhviev.edgedveaikaaieeakaekdkPsliklrtviGygspakagtedvhGapLgedevaalkkklGfdpeksf 283
                      t+ +ft+d+a+  +  gWhviev ++++++  ik+aie+a+ +++kPs+i ++t+iGyg+ +++gt+++hG++Lged v+ lkk  Gf+p+++f
       EFC37674.1 200 TDLTFTQDTAMVARGLGWHVIEVhDADSNLLRIKEAIETARLVTNKPSMIICKTTIGYGT-KQEGTAKAHGTALGEDSVRMLKKFCGFNPDDHF 292
                      ***********************88899********************************.9******************************** PP

                      ---HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHTT- CS
  Transketolase_N 284 evpeevydaykekvaegakaeeeWeekfaaykkkapeeaaelerrlsge 332
                       +p+ v +++++   ++ak  +eW+ + ++y++ +  e + l r+ +ge
       EFC37674.1 293 IIPSIVREEFEKISDRNAKYLQEWNDMTQKYANSHKSEWEMLMRMRRGE 341
                      ***********************************99999998888776 PP

>> Transket_pyr  Transketolase, pyrimidine binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.2   0.0   4.3e-45   1.3e-41       2     176 ..     358     529 ..     357     530 .. 0.98

  Alignments for each domain:
  == domain 1  score: 142.2 bits;  conditional E-value: 4.3e-45
                   EEEHHHHHHHHHHHHHCTTTTEEEEESSTHHHHTTCHCCHHEGGT...TEGEEE--S-HHHHHHHHHHHHHHCTTEEEEEEEEHHHHGGGHHGGHHH CS
  Transket_pyr   2 kiawrkaeaealaellkedpevvligaDvaggtfsvrkgllhdqg...egrvidsgisEqavlgfavGaalagpllviveaqFgdFangAqiyadqa 95 
                   ++a+r+ ++e+l+ + k  p +v+++aD++ ++++ ++g++++q+   egr++++g++E++++ + +G+  +g ll+ ++++F++Fa+    y   a
    EFC37674.1 358 SMATRMCSHEVLNGIFKIIPAMVGGSADLTPSNLTDIEGQKDFQPhsrEGRYFRFGVREHGMCSISNGILYHG-LLRTYVGTFLNFAS----YGLGA 449
                   789**********************************************************************.9*************....***** PP

                   HHCHHHHHT--EE.EEESBSGGGSTTGTTTSBSSHHHHHHTSTTEEEE--SSHHHHHHHHHHHHHSSS.SEEEEEE-SSEEC CS
  Transket_pyr  96 irsgeakgklkvg.vvtrlpigvgedGpehqsaeleaflrlipglkvvrPsdpaetkhllrrairredrkPvvlrlpksllr 176
                   ir ++a+ +l+ + v+t+++ig+gedGp+hq++e +  lr+ip+++v+rP+d  et +++  ai++  ++P++l+l++++++
    EFC37674.1 450 IR-LSALAQLPNIfVLTHDSIGLGEDGPTHQPIEVLTALRAIPNMNVIRPADGRETSGAYLSAIKT-LKTPTCLALSRQNVP 529
                   **.**************************************************************6.468**********97 PP

>> Transketolase_C  Transketolase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.5   0.0   2.5e-12   7.4e-09       5      55 ..     547     597 ..     543     651 .. 0.88

  Alignments for each domain:
  == domain 1  score: 35.5 bits;  conditional E-value: 2.5e-12
                      EEETTSSEEEEEETTHHHHHHHHHHHHHTTTTCEEEEE-SEEESHHHHHHH CS
  Transketolase_C   5 ilregkdvtlvayGsmveealeAaeeLekegisaeVvdlrtvkplDketil 55 
                       + e++dv+lva+Gs+v+  +eA ++L++++i+++ +++++ + +D + ++
       EFC37674.1 547 EQDENPDVILVATGSEVQLIVEAKKQLNERQINVRTISMPSWELFDAQPLE 597
                      5678******************************************99876 PP

>> DXP_synthase_N  1-deoxy-D-xylulose-5-phosphate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   1.1e-06    0.0034     116     176 ..     126     197 ..      12     208 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.1e-06
  DXP_synthase_N 116 sisaalGlava.....rdlkge.........kkkvvaviGDgaltgGmafealnnigelk.kkllvilNdNemsis 176
                      +  + G+ava     +    +         ++ +   +GDg l  Gm+ e++  +g+++ +k++v + dN+ +i+
      EFC37674.1 126 GMCNSIGMAVAechlsK----RfnrnelklfDHYTYVFCGDGDLMEGMSTEGMSFAGHQQlNKVIVFYDDNRITID 197
                     56677788888444431....133333444456667789*****************99873678888999999886 PP

>> DUF498  Protein of unknown function (DUF498/DUF598)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.055   1.6e+02       4      58 ..     189     251 ..     172     274 .. 0.79
   2 !   10.9   0.0   0.00012      0.37      49      87 ..     548     585 ..     506     587 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.055
                 EESSEEEETTEE...ESSEEEE-SSSEEE-THCSTTCEE......CHHHHHHCT..T..SEEEE CS
      DUF498   4 ygeggfelngvk...ysgsllvlpeeafawdvakaedlt......eeslellellepkpellil 58 
                 y+++ ++++g +   ++++ ++   + + w+v +++d +      +e++e + l+++kp ++i 
  EFC37674.1 189 YDDNRITIDGSTdltFTQDTAMV-ARGLGWHVIEVHDADsnllriKEAIETARLVTNKPSMIIC 251
                 88999999876656688888888.5667887555666666677888999999999999999993 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00012
                 ..T..SEEEEE-TTS-----HHHHHHHHCCTSEEEEE-H CS
      DUF498  49 lepkpellilGtGkrqlplspevrealnelgigvevmdt 87 
                  +++p+++++ tG+++++   e +++lne++i+v + ++
  EFC37674.1 548 QDENPDVILVATGSEVQL-IVEAKKQLNERQINVRTISM 585
                 4789***********654.56889*********988765 PP

>> E1_dh  Dehydrogenase E1 component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   8.7e-05      0.26     123     220 ..     153     249 ..      86     255 .. 0.76
   2 ?   -3.1   0.0      0.95   2.9e+03     143     165 ..     449     471 ..     448     474 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 8.7e-05
                 ---EEEEEEGGGTT-HHHHHHHHHHHHTT--.EEEEEEEESEETTEEHHHH-S---GGG..TTTTS-EEEEETTSHHHHHHHHHHHHHHHH.TTT--EE CS
       E1_dh 123 kevailliGDgAanqGdvyealnlaalwklp.vifvveNNkygisTeaekasaskeladrargvgipglrVdgnDplavyeAvkfAaerar.egkgpll 219
                 ++ + +++GDg   +G   e++ +a   +l  vi +   N++ i  +++     ++++  arg g   ++V   D        k+A+e ar   ++p++
  EFC37674.1 153 DHYTYVFCGDGDLMEGMSTEGMSFAGHQQLNkVIVFYDDNRITIDGSTDLTFTQDTAMV-ARGLGWHVIEVHDADSNLL--RIKEAIETARlVTNKPSM 248
                 677899*********************9996369999*******999988777776665.9999999999987775333..245555544313456666 PP

                 E CS
       E1_dh 220 i 220
                 i
  EFC37674.1 249 I 249
                 5 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.95
                 HHHHHHHTT--EEEEEEEESEET CS
       E1_dh 143 alnlaalwklpvifvveNNkygi 165
                 a+ l+al +lp ifv     +g+
  EFC37674.1 449 AIRLSALAQLPNIFVLTHDSIGL 471
                 6789***********98887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (682 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.49
# Mc/sec: 4208.44
//
Query:       EFC37675.1  [L=612]
Description: cyclin-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-38  129.4   1.3    1.4e-37  128.2   0.5    2.1  2  Cyclin_N  Cyclin, N-terminal domain
    1.4e-12   47.8   0.1    1.4e-12   47.8   0.1    2.9  2  Cyclin_C  Cyclin, C-terminal domain


Domain annotation for each model (and alignments):
>> Cyclin_N  Cyclin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.2   0.5   1.6e-41   1.4e-37       1     126 [.     319     445 ..     319     446 .. 0.98
   2 ?   -3.3   0.0      0.79   7.1e+03      53      83 ..     471     501 ..     466     502 .. 0.71

  Alignments for each domain:
  == domain 1  score: 128.2 bits;  conditional E-value: 1.6e-41
                 HHHHHHHHHHCHTS-STTCT.TCTSSS-HHHHHHHHHHHHHHHHHTT--TTHHHHHHHHHHHHHHHS---CCCHHHHHHHHHHHHHHHHSSS---HHHH CS
    Cyclin_N   1 dilknlieqelkflpkpdyl.dqqpelnpemRailidwlvevaekfkltpetlflavnyldRflskksvpkdklqlvgatcLllAaKveeisppkledl 98 
                 ++l++++ ++ k +p+p+y+   q++++++mR il+dw+ eva+ + l+petl+lavn+ldR lsk sv+++klq  g+++L++++K++ei pp+l+++
  EFC37675.1 319 EVLESMRLTQMKNKPNPRYMeTVQTDITSNMRCILVDWMNEVASMYTLSPETLYLAVNILDRSLSKMSVRRNKLQAFGVASLFISSKFNEITPPELNEF 417
                 57889999************999**************************************************************************** PP

                 HHHTTTSS-HHHHHHHHHHHHHHTTT-- CS
    Cyclin_N  99 vyitdeafteeeilemErliLetLnfdl 126
                 +yi+d+++ +ee+l +Er iL+ L+f+l
  EFC37675.1 418 IYIADDTYGKEEVLIIERIILNNLEFEL 445
                 **************************98 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.79
                 HHHHHHHHHHHHHS---CCCHHHHHHHHHHH CS
    Cyclin_N  53 flavnyldRflskksvpkdklqlvgatcLll 83 
                 +l++ +++  l++ +v +     ++a++L++
  EFC37675.1 471 YLTYYICEMQLQNIEVLNFPPSVIAASALMI 501
                 6777777777777777777777888888877 PP

>> Cyclin_C  Cyclin, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.8       1.6   1.5e+04      95     113 ..     144     162 ..     138     167 .. 0.49
   2 !   47.8   0.1   1.5e-16   1.4e-12       2      75 ..     449     526 ..     448     585 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 1.6
                 GSS--HHCCCCTCGGGCCC CS
    Cyclin_C  95 ssklqavrrkyssskfhkv 113
                 ++++q +  ++ +++++++
  EFC37675.1 144 QQQQQPITLQQHHPQYNNS 162
                 3444444444444444443 PP

  == domain 2  score: 47.8 bits;  conditional E-value: 1.5e-16
                 -HHHHHHHHHCCSSHT.-HCCHHCHHCHHHHHHCSCCHCCS-HHHHHHHHHHHCCHHHHS--S-HHHHHHC--....- CS
    Cyclin_C   2 tplsFlrrflkaadasedselrtlakylleltlldydflsyppSliAaaalllarstlnspewtetlehytgy....s 75 
                  p++F+++fl++ +  +++ ++ l+ y++e+ l++++ l++ppS+iAa+al+++++ ++ + w+++l  + g+     
  EFC37675.1 449 QPYDFIEKFLQICGVVDNPIVKYLTYYICEMQLQNIEVLNFPPSVIAASALMISLYLIDFNYWNSELACCFGFsnqaC 526
                 69**********9988888************************************************99999954440 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (612 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1289  (0.0718947); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.50
# Mc/sec: 3647.14
//
Query:       EFC37676.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.4   0.0       0.26   11.2   0.0    1.6  1  Raptor_N  Raptor N-terminal CASPase like domain


Domain annotation for each model (and alignments):
>> Raptor_N  Raptor N-terminal CASPase like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   1.5e-05      0.26      63     105 ..     319     362 ..     309     375 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 1.5e-05
    Raptor_N  63 lldptvedvkklcqslrrnakdervlfHYnGhg.vprptengei 105
                  ++  +e +++  q+l ++++++rvlf+Y+G g +p  t+++ei
  EFC37676.1 319 TIEEKLEAIERRKQELLKSYPNQRVLFFYFGKGsIPFETVEKEI 362
                 67788899999999*****************9834666777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.45
# Mc/sec: 4066.31
//
Query:       EFC37677.1  [L=475]
Description: chloromuconate cycloisomerase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-15   54.7   0.0    1.4e-14   54.2   0.0    1.3  1  MR_MLE_C  Enolase C-terminal domain-like
    0.00041   20.5   0.0      0.001   19.3   0.0    1.7  1  MR_MLE_N  Mandelate racemase / muconate lactonizing enzyme, N
      0.002   17.3   0.0      0.024   13.8   0.0    2.2  2  MAAL_C    Methylaspartate ammonia-lyase C-terminus


Domain annotation for each model (and alignments):
>> MR_MLE_C  Enolase C-terminal domain-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.2   0.0   2.4e-18   1.4e-14      48     219 ..     275     471 ..     226     473 .. 0.77

  Alignments for each domain:
  == domain 1  score: 54.2 bits;  conditional E-value: 2.4e-18
                 EEEEE-TTTSBHHHHHHHHHHH.......GGGT.ESEEESSSST...TTHHHHHHHHHH..HH.SSEEEESTTSSSHHHHHHHHHHTSESEEEEBHHHH CS
    MR_MLE_C  48 dlmvDanqawdlatAirvarel.......eeld.llwlEEPvpp...eddleglaelra..ra.sipiaagEslysradfrelleagavdivqpdvsrv 132
                    +Dan aw+++t ++++++l             ++lE+P+p    + +  +  ++++  ++ +i i a+Es+ + + ++++  +  +  +++++ ++
  EFC37677.1 275 HWSIDANSAWTPETSLEFLQQLkeklpnfL--PyFYMLEQPFPIlveSSESSKWEQVKQayENeGILIFADESVNTFENIANI--QSFIHGINIKLEKS 369
                 6789******************65543211..236789****9887644577788888888557*******************..99************ PP

                 TSHHHHHHHHHHHHH.TT-EEEEBSC.SSHHHHHHHHHH..HHTTTTBEEEEEEGGGGH...........TSGCSBSSSSEEETTEEECTSSSBTSSEB CS
    MR_MLE_C 133 gGitearkvaalaea.fgvpvapHsg.sgglglaaslhl..aaaipnllileyfldael...........leeelleeplevedGrvtvpdgpGlGvel 216
                 gGi +a++v +la++ ++++++++++ s+ l+   s hl  +a i + l  +    ++             +    e+ +  ++G + + ++pG+Gv++
  EFC37677.1 370 GGIRGALTVSELAKKhYNLKLWFGCMvSSRLSCTCSSHLmsLAEIGGDLDGSLLVAEHSqgfeggfdwrnDQVSNSESRIGRNHGEIVLLEKPGIGVDI 468
                 *************87489*******8448999999999965666654444444444444777789998778888888899999**************** PP

                 -HH CS
    MR_MLE_C 217 dee 219
                 +++
  EFC37677.1 469 KKD 471
                 954 PP

>> MR_MLE_N  Mandelate racemase / muconate lactonizing enzyme, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   1.7e-07     0.001      79     117 .]     167     205 ..     141     205 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 1.7e-07
                 HHHHHHHCSSCHHHHHHHHHHHHHHHHHHTTSBHHHHTT CS
    MR_MLE_N  79 aqllkravlgnmsAkaaidmAlwDlkakalnlpladLlG 117
                  q  ++       A+ +i+mA++Dl +k l+ pl++L+G
  EFC37677.1 167 DQIGEKHPEFEHCAQCGIEMAIFDLWGKILDKPLYNLIG 205
                 4555555556789*************************9 PP

>> MAAL_C  Methylaspartate ammonia-lyase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   4.1e-06     0.024      90     182 ..     287     378 ..     275     409 .. 0.83
   2 ?    0.6   0.0     0.043   2.6e+02     218     230 ..     455     467 ..     429     470 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.1e-06
      MAAL_C  90 ervadylakleeaa...apyklliegPldagskeeqierlaelreklkekgikvelvaDeWcntledirefvdaeaadlvqiktPDlGginntiea 182
                 e+ +++l++l+e+     py  ++e+P     ++++ ++ ++++++ +++gi   + aDe  nt+e+i +   ++  + + ik    Ggi+ ++  
  EFC37677.1 287 ETSLEFLQQLKEKLpnfLPYFYMLEQPFPILVESSESSKWEQVKQAYENEGI--LIFADESVNTFENIANI--QSFIHGINIKLEKSGGIRGALTV 378
                 56678999999875222699999****9999999999999*****9999885..689***********987..567999**********9876655 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.043
      MAAL_C 218 paqlLakPGlGvD 230
                    lL kPG+GvD
  EFC37677.1 455 EIVLLEKPGIGVD 467
                 56789*******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       640  (0.0356964); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.44
# Mc/sec: 3208.59
//
Query:       EFC37678.1  [L=556]
Description: cyclin A [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-29  101.4   0.0    6.2e-29  100.3   0.0    1.6  1  Cyclin_N  Cyclin, N-terminal domain
    1.3e-07   31.7   6.2    1.1e-06   28.7   0.0    3.1  3  Cyclin_C  Cyclin, C-terminal domain
  ------ inclusion threshold ------
       0.47   10.4  18.3       0.64    9.9  18.3    1.2  1  TFIIA     Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> Cyclin_N  Cyclin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.3   0.0     1e-32   6.2e-29       1     127 []     292     420 ..     292     420 .. 0.95

  Alignments for each domain:
  == domain 1  score: 100.3 bits;  conditional E-value: 1e-32
                 HHHHHHHHHHCHTS-STTCT.TCTSSS-HHHHHHHHHHHHHHHHHTT--TTHHHHHHHHHHHHHHHS---CC.CHHHHHHHHHHHHHHHHSSS---HHH CS
    Cyclin_N   1 dilknlieqelkflpkpdyl.dqqpelnpemRailidwlvevaekfkltpetlflavnyldRflskksvpkd.klqlvgatcLllAaKveeisppkled 97 
                 dil++l +++  ++ +p++   +q+++n +mR++l++w+  va++fkl petl+l++++ldRfl+k  v++   lq  g++cL++AaK+ e+ pp l++
  EFC37678.1 292 DILSYLFNNQSYKQVSPHVWrTTQKNVNAKMRTMLVEWIAGVAVSFKLLPETLYLSIDILDRFLCKVCVSNVkLLQGYGLACLFIAAKYCETAPPPLRQ 390
                 78999999999888889999999******************************************99888774789*********************** PP

                 HHHHTTTSS-HHHHHHHHHHHHHHTTT--- CS
    Cyclin_N  98 lvyitdeafteeeilemErliLetLnfdls 127
                 + +++d+++t+  il +E +i ++L+f+l+
  EFC37678.1 391 FLFAADNTYTRGLILSLESEICNALDFELC 420
                 ***************************996 PP

>> Cyclin_C  Cyclin, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.2      0.35   2.1e+03      50     106 ..      63     119 ..      51     131 .. 0.58
   2 !    4.6   0.6    0.0056        34      48      90 ..     151     193 ..     142     233 .. 0.60
   3 !   28.7   0.0   1.8e-10   1.1e-06       4     116 ..     425     544 ..     422     546 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.35
                 HHHHHCCHHHHS--S-HHHHHHC---HHHHHHHHHHHHHHHHHHHGSS--HHCCCCT CS
    Cyclin_C  50 aalllarstlnspewtetlehytgyskedlkpcvelilellssapssklqavrrkys 106
                 +++++     ++++  e+l ++t  ++ +     + +++ +++a++ +  +v ++ s
  EFC37678.1  63 SSVFHHHGGAKRQPHREALANITNSHEVQHTSSTNDLNKRVAQANNYSNLKVNTHSS 119
                 356666666677777777777776666666666666666664555444445444443 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0056
                 HHHHHHHCCHHH.......HS--S-HHHHHHC.---HHHHHHHHHHHHHHH CS
    Cyclin_C  48 Aaaalllarstl.......nspewtetlehyt.gyskedlkpcvelilell 90 
                 Aaa+ + + s++       n+++++ + +h+t +y         e  + + 
  EFC37678.1 151 AAAVAVSVHSMIhsnsasnNTQQFNTSSQHHTqQY--------TEDQQTFE 193
                 78888888888844444444444555555555555........44444444 PP

  == domain 3  score: 28.7 bits;  conditional E-value: 1.8e-10
                 HHHHHHHHCCSSHT.-HCCHHCHHCHHHHHHCSCCHCCS-HHHHHHHHHHHCCHHHHS--S-HHHHHHC--.....-HHHHHHHHHHHHHHH..HHHHG CS
    Cyclin_C   4 lsFlrrflkaadasedselrtlakylleltlldydflsyppSliAaaalllarstlnspewtetlehytgy.....skedlkpcvelilell..ssaps 95 
                 ++F+++fl   ++ +++ ++ la y++el l++ d l+y  S iA +++++a+++ ++    e l+ ++g      +   +++cv +   ++   s  +
  EFC37678.1 425 FDFVEKFLELIGHVNNARIKCLAYYICELQLQNFDALQYNKSGIALSSVIIALYVTGTACTLEGLVACLGGntdlaNITYINNCVMAVYCYYvqMSMGE 523
                 78999999998877788**************************************86666555555555443444455556666666666655444678 PP

                 SS--HHCCCCTCGGGCCCGGS CS
    Cyclin_C  96 sklqavrrkyssskfhkvstl 116
                  +++ ++ ky+ + f+ vst+
  EFC37678.1 524 IQHNFIKDKYARQSFGGVSTI 544
                 88899************9986 PP

>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9  18.3   0.00011      0.64      59     249 ..      56     241 ..       3     314 .. 0.45

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00011
       TFIIA  59 qfvlqlpqslkqalqasaaaasqapastsqslpslvipagksvqslt.a...nssaataatfslpakleppvqipa.gvtlqtasg..qlykvnv.... 146
                 + v ++p+s+ + +           + ++++++ + i+++++vq+++ +   n   +  a+ +  ++l+ + +  +  +tl+tas+  q   ++     
  EFC37678.1  56 SLVCNSPSSVFHHHG--------GAKRQPHREALANITNSHEVQHTSsTndlN---KRVAQANNYSNLKVNTHSSStFTTLSTASTntQ--CSKSflnp 141
                 333333322222221........122233344444555555555555433321...222222222222222222221344444444221..11112233 PP

       TFIIA 147 ..qasgaqqia..aqplqqvvqqsqgsaaqssvaalqaq.sqqaqalaepqqqlekqqqqqqqqqqqqqqqqvqqqqqeesqqaqqasqe......... 231
                    a+g++++a  a  ++++    +++ a++++++++ + ++++q+ +e qq+ e   qq++++ +++ ++q            ++             
  EFC37678.1 142 ysSANGKTNAAavAVSVHSM---IHSNSASNNTQQFNTSsQHHTQQYTEDQQTFE---QQVESSSSPLSSEQD-----------PN---Afnefsmeas 220
                 33222222222002222222...23333333334444332333333444333333...111111111111111...........11...0111211111 PP

       TFIIA 232 ..qvag.sqvessqtdgaeda 249
                   + ++ ++++ s++dg+++a
  EFC37678.1 221 deNYSSdEEMDESEDDGEQQA 241
                 111111133333344433332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (556 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1742  (0.097161); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 3310.77
//
Query:       EFC37679.1  [L=638]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (638 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1665  (0.0928663); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.50
# Mc/sec: 3874.70
//
Query:       EFC37680.1  [L=1118]
Description: hypothetical protein NAEGRDRAFT_81838 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-36  125.9   0.0    4.7e-36  124.4   0.0    1.8  1  DFP              DNA / pantothenate metabolism flavoprotein
    1.5e-14   54.5   0.0    3.6e-14   53.2   0.0    1.7  1  Methyltransf_25  Methyltransferase domain
    7.5e-14   51.9   0.0    1.5e-13   50.9   0.0    1.5  1  Methyltransf_23  Methyltransferase domain
    6.6e-11   42.7   0.0    1.6e-10   41.5   0.0    1.7  1  Methyltransf_11  Methyltransferase domain
      7e-10   38.9   0.2    2.3e-09   37.2   0.2    1.9  1  Methyltransf_31  Methyltransferase domain
      6e-08   33.3   0.3    1.9e-07   31.7   0.1    2.1  1  Methyltransf_12  Methyltransferase domain
    4.8e-07   29.5   0.1    1.1e-06   28.3   0.1    1.5  1  MTS              Methyltransferase small domain
    7.8e-05   22.1   0.3    0.00019   20.9   0.3    1.6  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
    0.00051   19.7   0.0     0.0016   18.1   0.0    1.8  1  NodS             Nodulation protein S (NodS)
     0.0016   17.9   1.0     0.0037   16.7   1.0    1.5  1  TehB             Tellurite resistance protein TehB
  ------ inclusion threshold ------
      0.014   14.5   0.7      0.044   12.9   0.7    1.7  1  Pox_MCEL         mRNA capping enzyme
      0.036   13.7   0.0      0.071   12.7   0.0    1.5  1  Cons_hypoth95    Conserved hypothetical protein 95
      0.067   13.1   0.0         12    5.7   0.0    2.5  2  Aldolase_II      Class II Aldolase and Adducin N-terminal dom


Domain annotation for each model (and alignments):
>> DFP  DNA / pantothenate metabolism flavoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  124.4   0.0   3.4e-39   4.7e-36       4     177 ..     415     595 ..     412     602 .. 0.86

  Alignments for each domain:
  == domain 1  score: 124.4 bits;  conditional E-value: 3.4e-39
                 -EEEEEES-EEEECCTTEEEEE----HHHHHHHHHHHHTT-EEEEEE-S-.SS---T..T-EEEE--SHHHHHHHHHHHHTT-..SEEEE---S--EEE CS
         DFP   4 kkvlvtaGpTrEaiDpVRfisNrSSGkmGyalAeaaaarGaeVtlvsgpv.sletpe..gvevvkvesaeemleaveealkea..divimaAAvaDyrp 97 
                  kv++t+G+T  +iD+VR+i+N+S+G++G+ +Ae++++rG+ V +++++  +++ ++  ++ ++ + + +e+le +++++ e+  d+vi +AAv+Dy +
  EFC37680.1 415 LKVVITSGGTAVPIDSVRYITNSSTGTTGALIAEEFVKRGHLVYYIHSKNgKVPSKKypNLILLPYFTFDEYLEVLKQTTIECnpDVVILSAAVSDYGV 513
                 58*********************************************9965777654115668889***********99977778************** PP

                 S-------------..----EEE---HHHHHHHC-S.S-EEEEEEE-....SS-HHHHHHHHHHHTT-SEEEEEEGGGT.TGGG- CS
         DFP  98 keaaeeKikkeeeeeeltleleknpdilaelaekkkkkqllvGFaae....teellenareklerkgldlivaNdvske.eagfg 177
                 ++a+e+Ki+   + ++ tl+l+k p+i++ + ++ ++k +lvGF++     te+l+++a +   r++++l vaN+++k+  ++fg
  EFC37680.1 514 QQAHEGKISS--DLDTQTLTLVKLPKIISLV-KHWNPKVFLVGFKLLagatTETLIDTAYKSGIRNHCNLTVANTTTKDdMSNFG 595
                 ********96..567899*************.67778889****987444257**********************9987223355 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.2   0.0   2.6e-17   3.6e-14       1      97 []     866     967 ..     866     967 .. 0.93

  Alignments for each domain:
  == domain 1  score: 53.2 bits;  conditional E-value: 2.6e-17
                      EEEET-TTSHHHHHHHCTSTSSEEEEEESSHHHHHHHHHHHHH...TTT..TEEEEESBCCGBSSSTTTEEEEEEESTGGG.SSHHHHHHHHHH CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrlgkakvtgvDiseemleaareraee...egl..nvefvqgdaedlpfedgsfDlvvssgalhh.lsdedlekalke 88 
                      vLdl+cGtG++++ + +r g +++t  D s++ml++a++++ +   e++   ++ ++ +++dl+ ++++fDl+v+++a+++ ++ e le ++k+
       EFC37680.1 866 VLDLACGTGEVSRLMYER-GLKNITFADQSDKMLNYAHKKFIDnfgEEIsnGISKHVTSMQDLKVNNEKFDLIVIRQAINYaMNLEGLEMIVKN 958
                      9*****************.68*******************988555444889999********************9999998999********* PP

                      HHHHEEEEE CS
  Methyltransf_25  89 iarvLkpgG 97 
                      ++++L++gG
       EFC37680.1 959 CYEHLNDGG 967
                      ********9 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.9   0.0   1.1e-16   1.5e-13       7     131 ..     848     985 ..     839    1044 .. 0.81

  Alignments for each domain:
  == domain 1  score: 50.9 bits;  conditional E-value: 1.1e-16
  Methyltransf_23   7 eelsdklerllpklraggrvLdiGcGtGillevlrengf.svtgvDlspeaveiae.............kakkaqkdqfdeqeaaepqgkfdlI 86 
                        l d l+r ++ ++++ +vLd++cGtG++++++ e+g  ++t+ D+s+++ + a              +++   k+ +  q+ +++++kfdlI
       EFC37680.1 848 TDLIDILDREFE-NKEKVKVLDLACGTGEVSRLMYERGLkNITFADQSDKMLNYAHkkfidnfgeeisnGIS---KHVTSMQDLKVNNEKFDLI 937
                      456677788886.88888********************989************9988888888887543222...22333458899******** PP

  Methyltransf_23  87 vlrevlehvpd...ppellrqiatllkpgGylllseplaslkedrlll 131
                      v r+ ++   +   +++ +++ +++l++gG l++ + + +l ++ ++ 
       EFC37680.1 938 VIRQAINYAMNlegLEMIVKNCYEHLNDGGKLIFNTTNFKLDQEGKFA 985
                      ********999555669******************9887665555444 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.5   0.0   1.2e-13   1.6e-10       1      96 []     867     971 ..     867     971 .. 0.90

  Alignments for each domain:
  == domain 1  score: 41.5 bits;  conditional E-value: 1.2e-13
                      EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-.....EEEETTEECCCTSS-TT-EEEEEEES-CCC-...CCHHHHHHHHH CS
  Methyltransf_11   1 LdvGcGtGrlaealakrg.arvvgvDlskemlklakekaseegl.....kvefvvadaeklpfednsfDlvvssevlhhv...edpekalkeia 85 
                      Ld++cGtG +++ + +rg ++++  D s++ml++a++k  ++        ++ +v ++++l++++++fDl+v+++++++    e +e ++k+++
       EFC37680.1 867 LDLACGTGEVSRLMYERGlKNITFADQSDKMLNYAHKKFIDNFGeeisnGISKHVTSMQDLKVNNEKFDLIVIRQAINYAmnlEGLEMIVKNCY 960
                      8*******************************999666655533567775555**************************9888999******** PP

                      HHEEEEEEEEE CS
  Methyltransf_11  86 RvLkpgGllvi 96 
                        L  gG+l++
       EFC37680.1 961 EHLNDGGKLIF 971
                      *********97 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.2   0.2   1.6e-12   2.3e-09       2     127 ..     861     989 ..     860    1033 .. 0.78

  Alignments for each domain:
  == domain 1  score: 37.2 bits;  conditional E-value: 1.6e-12
  Methyltransf_31   2 dkglrvlDlGCGtGeltfelaeelgpkaevvGiDiseeaielArenaqklgld....nveFeqgdieeleklledekfDlilsnevl...nala 88 
                      +++++vlDl+CGtGe +  ++e+    ++++  D s +++++A ++  +++ +     ++ ++ ++++l+  ++ ekfDli+ ++++   + l 
       EFC37680.1 861 KEKVKVLDLACGTGEVSRLMYERGL--KNITFADQSDKMLNYAHKKFIDNFGEeisnGISKHVTSMQDLK--VNNEKFDLIVIRQAInyaMNLE 950
                      57899****************7544..568889************5555554423337777778888877..999************7777777 PP

  Methyltransf_31  89 dpdkileeiervlkpggilliedprllaelpakveeesk 127
                       ++ i ++  + l++gg l+ ++ +   ++ +k+ + ++
       EFC37680.1 951 GLEMIVKNCYEHLNDGGKLIFNTTNFKLDQEGKFAKLRE 989
                      778888999*************99955555555544444 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7   0.1   1.4e-10   1.9e-07       1      99 []     867     969 ..     867     969 .. 0.87

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 1.4e-10
  Methyltransf_12   1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvelealdlldldgg...ssfDlvvasnvlhhl...kdirevldn 88 
                      L++ cGtG+++r + e+   +++t+ D s ++++ a +k+ ++ ++  +n   ++  + ++  +   ++fDl+v+ +++++    + ++ +++n
       EFC37680.1 867 LDLACGTGEVSRLMYER-GLKNITFADQSDKMLNYAHKKFIDNFGEEISNGISKHVTSMQDL-KvnnEKFDLIVIRQAINYAmnlEGLEMIVKN 958
                      89************999.888999*********99999999988877777666655544333.34799*************999999******* PP

  Methyltransf_12  89 irklLkpgGrl 99 
                      ++++L++gG+l
       EFC37680.1 959 CYEHLNDGGKL 969
                      *********97 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.1   7.9e-10   1.1e-06      23     138 ..     854     972 ..     845     995 .. 0.80

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 7.9e-10
                 HHHHCHCCTCSEEEEET-TTSHHHHHHHHHTTC.EEEEEESBHHHHHHHHHHHHHTTGC......EEEEE-STTTTSTTS-EEEEEE---STTTCHCHH CS
         MTS  23 LletlpkelsgkvlDlGcGaGvlgaalakespeaevtlvdvdarAlesakenleankle......vevvasdvleeveekkfdlivsNPPfhagkatel 115
                 L + ++++++ kvlDl+cG+G ++  + ++  + ++t+ d++ + l+ a++ + +n  e       + v+s    +v+++kfdliv    +    +  l
  EFC37680.1 854 LDREFENKEKVKVLDLACGTGEVSRLMYERGLK-NITFADQSDKMLNYAHKKFIDNFGEeisngiSKHVTSMQDLKVNNEKFDLIVIRQAINYAMN--L 949
                 444566668889************999998877.7*******************99888887764333444444467799******8777766555..8 PP

                 HHHHHHHHHHHHHEEEEEEEEEE CS
         MTS 116 avaeeliaeAkeaLkegGeLliV 138
                 +  e ++++  e+L++gG+L++ 
  EFC37680.1 950 EGLEMIVKNCYEHLNDGGKLIFN 972
                 8999***************9874 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.3   1.4e-07   0.00019      44     150 ..     859     970 ..     831     979 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 1.4e-07
                      -S--TTEEEEES-TT-HHHHHHHHHHHHHH..EEEEEES-HHHHHHHHHHHHHH.TSS...TEEEEE--TTT-TTS-T-EEEEEEES-GG...G CS
  Ubie_methyltran  44 avkrgakvlDvagGtgDlafklsdsvgekg..kvvvlDinenmLkvgekklkee.gki...nieflqanaeeLpfeddsfDvvtvsfGlr...n 128
                       +k+  kvlD+a+Gtg+++  + +    +g  +++ +D +++mL+ ++kk  ++ g      i   +++ ++L+ +++ fD++ +   +    n
       EFC37680.1 859 ENKEKVKVLDLACGTGEVSRLMYE----RGlkNITFADQSDKMLNYAHKKFIDNfGEEisnGISKHVTSMQDLKVNNEKFDLIVIRQAINyamN 948
                      567888**********98655444....4444899**************9876514334557888889999************99888753337 PP

                      -S-HHHHHHHHHHHEEEEEEEE CS
  Ubie_methyltran 129 vtDklkaLkeayrvlkpGGrlv 150
                      +   +  +k+ y  l  GG+l+
       EFC37680.1 949 LEGLEMIVKNCYEHLNDGGKLI 970
                      7788888999999999999885 PP

>> NodS  Nodulation protein S (NodS)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   1.2e-06    0.0016      66     146 ..     886     973 ..     843     981 .. 0.69

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.2e-06
        NodS  66 krltvvdvveeaiararerv.ke.....sshiswivsdvqqfst.dekfdlivvaevlyyiedvaelraavrnlvsllapdgqlvfGs 146
                 k++t  d  ++ ++ a+++  ++     s+ is +v+ +q ++  +ekfdliv+ + + y  +++ l   v+n  + l  +g+l+f +
  EFC37680.1 886 KNITFADQSDKMLNYAHKKFiDNfgeeiSNGISKHVTSMQDLKVnNEKFDLIVIRQAINYAMNLEGLEMIVKNCYEHLNDGGKLIFNT 973
                 55555555555555554443111111113468899999999986268***************************************76 PP

>> TehB  Tellurite resistance protein TehB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   1.0   2.7e-06    0.0037      31     129 ..     863     968 ..     838     977 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.7e-06
                 S-EEEEES-TTSHHHHHHHHTT-.EEEEEES-HHHHHHHHH.HHH...HTT-TTEEEEE--GGG----.S-EEEEEEESSG.GGS-GGGHHHHHHHHHH CS
        TehB  31 pgkvldlgcgqgrnslylsllgy.dvtawdknensiaflee.ike...kenlknistalydineakld.erydfilstvvl.mfleaeripsiienmqe 122
                   kvldl cg g  s  +   g  ++t  d+ ++ +++ ++  ++    e  ++is  +  ++++k++ e++d+i+    +   ++ e +  i++n  e
  EFC37680.1 863 KVKVLDLACGTGEVSRLMYERGLkNITFADQSDKMLNYAHKkFIDnfgEEISNGISKHVTSMQDLKVNnEKFDLIVIRQAInYAMNLEGLEMIVKNCYE 961
                 579************999999974688888888877665431222121466789***********996379***9876555156899************ PP

                 TEEEEEE CS
        TehB 123 ctkvggy 129
                 + + gg 
  EFC37680.1 962 HLNDGGK 968
                 ****995 PP

>> Pox_MCEL  mRNA capping enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.7   3.2e-05     0.044      57     188 ..     856     975 ..     843     989 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.2e-05
    Pox_MCEL  57 ktkldesnklkvLdldcgkGgDLeKyekgeIsklvatDiaeesieeckeRYnklrsekkskyykFdaelirsdsfvssvrevfedyelkfdivslQFai 155
                 ++++ +++k+kvLdl+cg G   +     +++++  +D +++ ++ +++++            +F  e+  + s +++  + ++  + kfd++ +  ai
  EFC37680.1 856 REFE-NKEKVKVLDLACGTGEVSRLMYERGLKNITFADQSDKMLNYAHKKFI----------DNFGEEISNGISKHVTSMQDLKVNNEKFDLIVIRQAI 943
                 4444.899**********9976666666788899999999999999999982..........23666666666655555555556789*********** PP

    Pox_MCEL 156 HYsFeseekartvlrNvaellasGGkvlgTtpd 188
                  Y+ + e    ++++N  e l+ GGk++  t +
  EFC37680.1 944 NYAMNLEGLE-MIVKNCYEHLNDGGKLIFNTTN 975
                 ****998776.****************987765 PP

>> Cons_hypoth95  Conserved hypothetical protein 95
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   5.2e-05     0.071      40     119 ..     861     939 ..     848     995 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.2e-05
                    HCC-EEEETT-TTSHHHHHHHHTT-SEEEEEES-HHHHH.HHHHHHCCCT--TTTEEEEES-HHHHCTS--SS-EEEEEEE CS
  Cons_hypoth95  40 iegarvLDlfaGsGalglEAlSRgakkavlvekdkeavk.ilkenleelkleeetaelkedaleallklakkkeefdivfl 119
                     e+ +vLDl +G+G ++     Rg k++++ ++++++++ + k+ +++++  ee+++ + +++ +++ l  ++e+fd++ +
     EFC37680.1 861 KEKVKVLDLACGTGEVSRLMYERGLKNITFADQSDKMLNyAHKKFIDNFG--EEISNGISKHVTSMQDLKVNNEKFDLIVI 939
                    46779********************************9956677789999..56999999999999999999******976 PP

>> Aldolase_II  Class II Aldolase and Adducin N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.022        30      22      94 ..     690     766 ..     682     771 .. 0.73
   2 ?    5.7   0.0    0.0089        12     131     172 ..     778     821 ..     769     826 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.022
                  EEEEEET.STTEEEEEBTSS-GGGHTGGGEE...EEETTSCEEEEC.ECSSSTB-TTHHHHHHHHHH-TT-SEEEEE- CS
  Aldolase_II  22 niSvrvp.eedsflitpsgvdfeeltaedlv...vvdldsgevveg.kekggkpssetplHlaiykarpdaravvHtH 94 
                   + +r p    +flit  g d+++ +  d++   +vd++ ++ ++  ++ + k+s    +  +++++rp ++ ++H+H
   EFC37680.1 690 FVAMRAPePYSGFLITSRGSDKSQPSIKDITyisKVDFQ-ARTLHVhSTHRQKASLNANVAGWLFENRPLVNLILHAH 766
                  555664433567999999999999997666511155665.444433457788999999999***************** PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0089
                  -SSTTCHHHHHHHHHHHHHS-SEEEETTTEEEEEES..SHHHHH CS
  Aldolase_II 131 yaapgteelgealaealkedakavllrnHGlltvGe..tleeAv 172
                  ++ pgt+e  +a+a+++ ++ k+v +  HG++ v +   +eeA 
   EFC37680.1 778 DYSPGTQEDVDAVARKMSNNEKIVEIPDHGVISVSNssRIEEAI 821
                  4557999999********8889***********99611466665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.85u 0.32s 00:00:01.17 Elapsed: 00:00:00.49
# Mc/sec: 6875.77
//
Query:       EFC37681.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.6e-91  293.6  81.0    8.7e-08   31.6   0.3   15.1 15  MORN           MORN repeat
    0.00016   22.0  24.5        2.4    8.6   0.4    6.7  6  DUF3048_C      Protein of unknown function (DUF3048) C-termin
  ------ inclusion threshold ------
      0.039   13.9   9.0         11    5.9   0.1    5.1  5  Peptidase_S55  SpoIVB peptidase S55
       0.16   11.4   2.7         96    2.5   0.0    4.7  5  DUF4926        Domain of unknown function (DUF4926)
       0.18   12.3   0.1         24    5.6   0.0    2.7  3  Sar8_2         Sar8.2 family
        5.7    7.5  10.2        4.2    7.9   1.1    3.1  4  PilJ_C         Pili PilJ C-terminal domain
        9.1    5.9   5.8          7    6.2   0.3    3.2  3  NUC205         NUC205 domain


Domain annotation for each model (and alignments):
>> MORN  MORN repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.2   2.8e-05     0.071       1      20 [.       7      26 ..       7      29 .. 0.94
   2 !   27.1   2.5   9.7e-10   2.5e-06       1      22 [.      30      51 ..      30      52 .. 0.97
   3 !   31.6   0.3   3.4e-11   8.7e-08       1      23 []      53      75 ..      53      75 .. 0.98
   4 !   20.4   0.1   1.3e-07   0.00033       1      23 []      76      98 ..      76      98 .. 0.98
   5 !   24.2   1.1   7.6e-09     2e-05       1      23 []      99     121 ..      99     121 .. 0.98
   6 !   22.1   0.1   3.6e-08   9.1e-05       1      19 [.     122     140 ..     122     143 .. 0.95
   7 !   27.3   0.7   7.9e-10     2e-06       1      22 [.     150     171 ..     150     172 .. 0.97
   8 !   31.1   3.3   4.9e-11   1.3e-07       1      23 []     173     195 ..     173     195 .. 0.98
   9 !   31.5   0.1   3.9e-11   9.9e-08       1      22 [.     196     217 ..     196     218 .. 0.96
  10 !   20.0   0.5   1.7e-07   0.00044       1      22 [.     219     240 ..     219     241 .. 0.92
  11 !   23.4   0.1   1.4e-08   3.6e-05       1      22 [.     242     263 ..     242     264 .. 0.97
  12 !   27.4   0.6   7.7e-10     2e-06       1      22 [.     265     286 ..     265     287 .. 0.97
  13 !   16.5   0.0   2.2e-06    0.0056       1      22 [.     288     309 ..     288     310 .. 0.94
  14 !   20.2   0.1   1.4e-07   0.00037       1      23 []     311     333 ..     311     333 .. 0.95
  15 !    8.0   0.4    0.0011       2.8       1      15 [.     334     348 ..     334     350 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.8e-05
        MORN  1 YeGeWknGkrhGkGvytwpd 20
                Y+Ge  +G +hGkG++++++
  EFC37681.1  7 YSGEIEDGCFHGKGTMIYAN 26
                99*****************9 PP

  == domain 2  score: 27.1 bits;  conditional E-value: 9.7e-10
        MORN  1 YeGeWknGkrhGkGvytwpdGd 22
                YeG+W++Gk+hG G +t++dG+
  EFC37681.1 30 YEGDWVKGKKHGVGAFTYSDGS 51
                *********************8 PP

  == domain 3  score: 31.6 bits;  conditional E-value: 3.4e-11
        MORN  1 YeGeWknGkrhGkGvytwpdGdr 23
                YeGeW n++ +GkG++ +++G+r
  EFC37681.1 53 YEGEWINDQINGKGTFLYANGNR 75
                *********************97 PP

  == domain 4  score: 20.4 bits;  conditional E-value: 1.3e-07
        MORN  1 YeGeWknGkrhGkGvytwpdGdr 23
                Y GeW +    G Gv++++dGdr
  EFC37681.1 76 YVGEWADSVISGRGVLYYSDGDR 98
                99*******************97 PP

  == domain 5  score: 24.2 bits;  conditional E-value: 7.6e-09
        MORN   1 YeGeWknGkrhGkGvytwpdGdr 23 
                 Y+Ge+k+G+++G G+y ++ Gdr
  EFC37681.1  99 YDGEFKEGRMNGEGIYCYAEGDR 121
                 9********************97 PP

  == domain 6  score: 22.1 bits;  conditional E-value: 3.6e-08
        MORN   1 YeGeWknGkrhGkGvytwp 19 
                 YeG +++++rhGkG++ ++
  EFC37681.1 122 YEGSFVDDQRHGKGIMSYA 140
                 ****************997 PP

  == domain 7  score: 27.3 bits;  conditional E-value: 7.9e-10
        MORN   1 YeGeWknGkrhGkGvytwpdGd 22 
                 YeG+W  Gk++G+G+y ++dG+
  EFC37681.1 150 YEGDWAFGKMEGIGKYLYSDGS 171
                 *********************8 PP

  == domain 8  score: 31.1 bits;  conditional E-value: 4.9e-11
        MORN   1 YeGeWknGkrhGkGvytwpdGdr 23 
                 YeGeWk+Gk++G+G y + +G+r
  EFC37681.1 173 YEGEWKDGKMNGQGLYKFQNGNR 195
                 *********************97 PP

  == domain 9  score: 31.5 bits;  conditional E-value: 3.9e-11
        MORN   1 YeGeWknGkrhGkGvytwpdGd 22 
                 YeGe++n+++hGkG++++++G 
  EFC37681.1 196 YEGEFVNDQKHGKGILRYANGE 217
                 *********************5 PP

  == domain 10  score: 20.0 bits;  conditional E-value: 1.7e-07
        MORN   1 YeGeWknGkrhGkGvytwpdGd 22 
                 YeG Wk +k+hG G++t++ Gd
  EFC37681.1 219 YEGSWKTDKPHGMGTLTYSHGD 240
                 ******************8665 PP

  == domain 11  score: 23.4 bits;  conditional E-value: 1.4e-08
        MORN   1 YeGeWknGkrhGkGvytwpdGd 22 
                 Y Ge++n k+hGkG +++ +Gd
  EFC37681.1 242 YVGEFVNAKKHGKGSLVYRNGD 263
                 99*******************8 PP

  == domain 12  score: 27.4 bits;  conditional E-value: 7.7e-10
        MORN   1 YeGeWknGkrhGkGvytwpdGd 22 
                 Y+GeWkn+  +G+Gv+ +++G+
  EFC37681.1 265 YDGEWKNDHANGYGVLEYANGS 286
                 9********************8 PP

  == domain 13  score: 16.5 bits;  conditional E-value: 2.2e-06
        MORN   1 YeGeWknGkrhGkGvytwpdGd 22 
                 YeG+++++k+hG+ + + +dG+
  EFC37681.1 288 YEGNFVDDKKHGQAIVRSSDGS 309
                 *************999999997 PP

  == domain 14  score: 20.2 bits;  conditional E-value: 1.4e-07
        MORN   1 YeGeWknGkrhGkGvytwpdGdr 23 
                 +eG++ nG+++G Gv+t  dG++
  EFC37681.1 311 FEGTYENGRKEGEGVLTLQDGSV 333
                 79*******************85 PP

  == domain 15  score: 8.0 bits;  conditional E-value: 0.0011
        MORN   1 YeGeWknGkrhGkGv 15 
                 Y G Wk+G+  G G 
  EFC37681.1 334 YKGVWKDGLIVGMGY 348
                 99**********995 PP

>> DUF3048_C  Protein of unknown function (DUF3048) C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   1.7    0.0027         7      63     100 ..      38      74 ..       6      77 .. 0.72
   2 ?    2.9   0.0     0.053   1.4e+02      64     100 ..      84     120 ..      77     123 .. 0.85
   3 !    6.8   0.4    0.0035       8.8      70     100 ..     164     194 ..     148     199 .. 0.81
   4 !    7.3   0.4    0.0023       5.8      66     100 ..     205     240 ..     189     245 .. 0.69
   5 !    8.6   0.4   0.00095       2.4      64      99 ..     251     285 ..     235     292 .. 0.72
   6 ?    1.8   0.1      0.12   3.2e+02      67      84 ..     321     339 ..     300     342 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0027
                 E-SS-EEEEEEETTEEEEEEEEE..ETTEEEEE.ETTE CS
   DUF3048_C  63 dltgsgegyvftnGkaieitWskesedgptkyydedGk 100
                 + +g g +   ++G ++e++W +++ +g+ ++++++G+
  EFC37681.1  38 KKHGVG-AFTYSDGSYYEGEWINDQINGKGTFLYANGN 74 
                 333333.5667899999999999999999999988887 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.053
                 -SS-EEEEEEETTEEEEEEEEE..ETTEEEEE.ETTE CS
   DUF3048_C  64 ltgsgegyvftnGkaieitWskesedgptkyydedGk 100
                 +++++ +++ ++G  +++++++   +g   y++++G+
  EFC37681.1  84 VISGRGVLYYSDGDRYDGEFKEGRMNGEGIYCYAEGD 120
                 4566678999*************99999999998886 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0035
                 EEEEETTEEEEEEEEE..ETTEEEEE.ETTE CS
   DUF3048_C  70 gyvftnGkaieitWskesedgptkyydedGk 100
                  y+ ++G ++e++W+  + +g+  y  ++G+
  EFC37681.1 164 KYLYSDGSIYEGEWKDGKMNGQGLYKFQNGN 194
                 47889************99999888887787 PP

  == domain 4  score: 7.3 bits;  conditional E-value: 0.0023
                 S-EEEEE.EETTEEEEEEEEE..ETTEEEEE.ETTE CS
   DUF3048_C  66 gsgegyv.ftnGkaieitWskesedgptkyydedGk 100
                 + g+g++   nG+++e++W+ ++  g  +++++ G+
  EFC37681.1 205 KHGKGILrYANGEVYEGSWKTDKPHGMGTLTYSHGD 240
                 34444332679***********99988888877775 PP

  == domain 5  score: 8.6 bits;  conditional E-value: 0.00095
                 -SS-EEEEEEETTEEEEEEEEE..ETTEEEEE.ETT CS
   DUF3048_C  64 ltgsgegyvftnGkaieitWskesedgptkyydedG 99 
                  +g+g  +v +nG +++++W+++ ++g  ++ +++G
  EFC37681.1 251 KHGKG-SLVYRNGDIYDGEWKNDHANGYGVLEYANG 285
                 33344.46789************9997766666566 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.12
                 -EE.EEEEETTEEEEEEEE CS
   DUF3048_C  67 sge.gyvftnGkaieitWs 84 
                 +ge ++ +++G ++++ W+
  EFC37681.1 321 EGEgVLTLQDGSVYKGVWK 339
                 3331566788888888887 PP

>> Peptidase_S55  SpoIVB peptidase S55
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.1    0.0084        22       6      23 ..      32      49 ..      27      54 .. 0.86
   2 ?    3.8   0.1     0.018        47       2      23 ..      51      72 ..      50      78 .. 0.84
   3 ?   -0.0   0.0      0.28   7.2e+02       6      29 ..     124     147 ..     120     153 .. 0.85
   4 ?    5.9   0.1    0.0043        11       5      25 ..     220     240 ..     216     270 .. 0.76
   5 ?    0.2   0.1      0.24   6.2e+02       6      54 ..     267     312 ..     262     328 .. 0.70

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0084
  Peptidase_S55  6 GlwvrdsaaGiGtltfvd 23
                   G wv+ + +G+G++t+ d
     EFC37681.1 32 GDWVKGKKHGVGAFTYSD 49
                   88**************98 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.018
  Peptidase_S55  2 eyklGlwvrdsaaGiGtltfvd 23
                   +y  G w+ d+++G Gt+ + +
     EFC37681.1 51 SYYEGEWINDQINGKGTFLYAN 72
                   677899***********99987 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.28
  Peptidase_S55   6 GlwvrdsaaGiGtltfvdpetkkf 29 
                    G +v d+ +G G +++  ++ + f
     EFC37681.1 124 GSFVDDQRHGKGIMSYAGENGSIF 147
                    889*************98776665 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.0043
  Peptidase_S55   5 lGlwvrdsaaGiGtltfvdpe 25 
                     G w  d+ +G+Gtlt+ + +
     EFC37681.1 220 EGSWKTDKPHGMGTLTYSHGD 240
                    69999************9843 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.24
  Peptidase_S55   6 GlwvrdsaaGiGtltfvdpetkkfgaLGHeisdvdtge.lleikeGeive 54 
                    G w  d+a+G G l + +   +++   G  + d++ g+ +++ ++G+i+e
     EFC37681.1 267 GEWKNDHANGYGVLEYANG--SSYE--GNFVDDKKHGQaIVRSSDGSIFE 312
                    7788999999999999883..3444..66677766654145666777766 PP

>> DUF4926  Domain of unknown function (DUF4926)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0     0.099   2.5e+02      25      42 ..     113     130 ..     110     134 .. 0.90
   2 ?   -2.7   0.0       1.6     4e+03      18      31 ..     140     153 ..     139     156 .. 0.79
   3 ?    2.2   0.1     0.044   1.1e+02      26      42 ..     188     204 ..     186     207 .. 0.85
   4 ?    0.1   0.0      0.21   5.3e+02      28      42 ..     236     250 ..     231     253 .. 0.78
   5 ?    2.5   0.0     0.037        96      25      48 ..     279     302 ..     276     306 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.099
     DUF4926  25 VevyeegeaYeVEFsddd 42 
                 +++y+eg+ Ye  F+dd+
  EFC37681.1 113 IYCYAEGDRYEGSFVDDQ 130
                 579************986 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.6
     DUF4926  18 rGqvGTvVevyeeg 31 
                 +G+ G + e+ye +
  EFC37681.1 140 AGENGSIFERYEGD 153
                 7999*****99755 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.044
     DUF4926  26 evyeegeaYeVEFsddd 42 
                 +++++g+ Ye EF++d+
  EFC37681.1 188 YKFQNGNRYEGEFVNDQ 204
                 5788889********86 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.21
     DUF4926  28 yeegeaYeVEFsddd 42 
                 y++g++Y  EF++++
  EFC37681.1 236 YSHGDKYVGEFVNAK 250
                 667777******986 PP

  == domain 5  score: 2.5 bits;  conditional E-value: 0.037
     DUF4926  25 VevyeegeaYeVEFsdddGeTlal 48 
                 V +y++g+ Ye  F+dd+ + +a+
  EFC37681.1 279 VLEYANGSSYEGNFVDDKKHGQAI 302
                 67899999********99777666 PP

>> Sar8_2  Sar8.2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       3.2   8.1e+03      43      58 ..     125     140 ..     121     164 .. 0.66
   2 ?    3.6   0.0     0.039        99      41      65 ..     197     221 ..     192     232 .. 0.86
   3 ?    5.6   0.0    0.0094        24      41      65 ..     289     313 ..     284     324 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 3.2
      Sar8_2  43 nnisdqktGagiirkl 58 
                   + dq+ G+gi+   
  EFC37681.1 125 SFVDDQRHGKGIMSYA 140
                 5678999999998643 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.039
      Sar8_2  41 nsnnisdqktGagiirklagkilka 65 
                 +++ + dqk G+gi+r  +g ++ +
  EFC37681.1 197 EGEFVNDQKHGKGILRYANGEVYEG 221
                 577899**********999998765 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0094
      Sar8_2  41 nsnnisdqktGagiirklagkilka 65 
                 ++n + d+k G+ i+r+  g i+ +
  EFC37681.1 289 EGNFVDDKKHGQAIVRSSDGSIFEG 313
                 7999****************99876 PP

>> PilJ_C  Pili PilJ C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   1.1    0.0017       4.2      17      76 ..      27      85 ..      22      96 .. 0.85
   2 ?   -1.6   0.0       1.5     4e+03      74      86 ..     164     174 ..     116     184 .. 0.68
   3 ?    0.1   0.3      0.47   1.2e+03      19      64 ..     172     217 ..     146     225 .. 0.63
   4 ?    4.4   0.4     0.021        54      17      72 ..     216     270 ..     201     292 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0017
      PilJ_C 17 kekyggkwpkvdeellekeeyegddlYiqpYikkvksegevvlyantaketgdkWranlv 76
                +eky+g+w k +++ +    y+   +Y   +i+++ ++  ++lyan +    ++W  + +
  EFC37681.1 27 QEKYEGDWVKGKKHGVGAFTYSDGSYYEGEWINDQINGKGTFLYANGN-RYVGEWADSVI 85
                689*******************999********8888888******99.66667876655 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.5
      PilJ_C  74 nlvYdpedgkwYq 86 
                 +++Y   dg++Y 
  EFC37681.1 164 KYLYS--DGSIYE 174
                 44444..666655 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.47
      PilJ_C  19 kyggkwpkvdeellekeeyegddlYiqpYikkvksegevvlyanta 64 
                 +y+g+w   + +    ++ ++ + Y   +++++k++  ++ yan +
  EFC37681.1 172 IYEGEWKDGKMNGQGLYKFQNGNRYEGEFVNDQKHGKGILRYANGE 217
                 4666666555444444444444456666777666666677777665 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.021
      PilJ_C  17 kekyggkwpkvdeellekeeyegddlYiqpYikkvksegevvlyantaketgdkWr 72 
                  e+y+g w + + + +    y+  d Y+  +++++k++   ++y n +    ++W+
  EFC37681.1 216 GEVYEGSWKTDKPHGMGTLTYSHGDKYVGEFVNAKKHGKGSLVYRNGD-IYDGEWK 270
                 679*****99999999999999999********777777788888777.6777775 PP

>> NUC205  NUC205 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.5      0.34   8.6e+02      23      30 ..      47      54 ..      46      56 .. 0.90
   2 ?    6.2   0.3    0.0028         7      22      30 ..     166     174 ..     165     176 .. 0.92
   3 ?   -0.6   0.0      0.39   9.9e+02      23      30 ..     305     312 ..     300     314 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.34
      NUC205 23 sSDGCiye 30
                +SDG+ ye
  EFC37681.1 47 YSDGSYYE 54
                9****998 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0028
      NUC205  22 LsSDGCiye 30 
                 L+SDG+iye
  EFC37681.1 166 LYSDGSIYE 174
                 9*******9 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.39
      NUC205  23 sSDGCiye 30 
                 sSDG+i e
  EFC37681.1 305 SSDGSIFE 312
                 8***9977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       244  (0.0136092); expected 358.6 (0.02)
Passed bias filter:                      171  (0.00953762); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 2038.90
//
Query:       EFC37682.1  [L=500]
Description: hypothetical protein NAEGRDRAFT_81839 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (500 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1259  (0.0702214); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.49
# Mc/sec: 3038.42
//
Query:       EFC37683.1  [L=326]
Description: hypothetical protein NAEGRDRAFT_81840 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (326 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1127  (0.0628591); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 1924.01
//
Query:       EFC37684.1  [L=1255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0066   16.6   0.1     0.0066   16.6   0.1    4.2  4  Membr_traf_MHD  Munc13 (mammalian uncoordinated) homology dom
  ------ inclusion threshold ------
      0.046   13.7   2.1       0.22   11.5   2.1    2.2  1  CCDC32          Coiled-coil domain containing 32


Domain annotation for each model (and alignments):
>> Membr_traf_MHD  Munc13 (mammalian uncoordinated) homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       1.5   1.3e+04      67      95 ..      22      50 ..       5      82 .. 0.53
   2 ?   -5.7   5.8         2   1.8e+04      44      44 ..     248     248 ..     121     354 .. 0.59
   3 ?    0.6   1.1     0.062   5.6e+02       6      63 ..     413     468 ..     409     516 .. 0.65
   4 !   16.6   0.1   7.4e-07    0.0066      96     147 ..    1095    1145 ..    1011    1147 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 1.5
  Membr_traf_MHD 67 aakkleslsklllsmvreevsgfeksLtp 95
                     + + ++ +++ l ++++ + +++++L+ 
      EFC37684.1 22 RQPQQQQQQQSILPQYKDVIDKVNEPLSL 50
                    23333333344444555556666666653 PP

  == domain 2  score: -5.7 bits;  conditional E-value: 2
  Membr_traf_MHD  44 l 44 
                     +
      EFC37684.1 248 V 248
                     3 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.062
  Membr_traf_MHD   6 LmdyLdsnLsilaqalektvLkrvlkelWkvvlnalekllLPplsdakskkkssslwe 63 
                     ++ +L++nL+il+++ + + +  +l ++ + +    ++ +L +ls++++k ks+++  
      EFC37684.1 413 MVRVLNENLKILSTSSNYKTM-GILAQMYDQIRPYKKQ-VLKELSSQSTKDKSKKILM 468
                     667899999999999887775.6888999888766666.9999999998774444422 PP

  == domain 4  score: 16.6 bits;  conditional E-value: 7.4e-07
  Membr_traf_MHD   96 kevevleaaLdtlkdfFhagGeGlkkeaLkseelqsLllalslYdqstdeLi 147 
                       +  +++ +Ld lkd F a+GeGl  ++L  ++ ++L      Y+ +td Li
      EFC37684.1 1095 SQKVTVQLCLDGLKDLFNASGEGLDSKFLD-QQSRELDILILIYNDETDILI 1145
                      566789***********************4.455778888888999999998 PP

>> CCDC32  Coiled-coil domain containing 32
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   2.1   2.4e-05      0.22      23      89 ..     265     331 ..     251     341 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.4e-05
      CCDC32  23 eeFeDsFlsssqeeeeeeeaseskasssskkwepledSevYlasLErkLkkikkqskevtskdlLes 89 
                  eF D  ++++q+++ +++ ++s + ++  +++ +  S + l +L ++L+ + k+s+  t   l + 
  EFC37684.1 265 VEFIDEKKPNEQQQHVHSNLTNSPNDGNIPPLQQVSSSRDSLSKLQKRLQTVMKGSSTTTNTSLQHQ 331
                 58999999999999999999999999999999999*********************96666555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1654  (0.0922528); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.95u 0.31s 00:00:01.26 Elapsed: 00:00:00.50
# Mc/sec: 7599.13
//
Query:       EFC37685.1  [L=445]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.06   13.3   1.3          5    7.0   0.1    2.4  2  APC1_C    Anaphase-promoting complex sub unit 1 C-terminal do


Domain annotation for each model (and alignments):
>> APC1_C  Anaphase-promoting complex sub unit 1 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.1   0.00028         5      43      87 ..      91     146 ..      81     238 .. 0.79
   2 ?    5.1   0.1    0.0011        20      51     142 ..     296     396 ..     291     422 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00028
                 HHHTT-TTHHHHHHHHHHHHHHHHHT...........---S-HHHHHHHHHHHHHS CS
      APC1_C  43 CltkDkpelLplylslykllqtlakq...........ssaaslalwdlrlvlefys 87 
                 Clt++  e+L +y s   +l  +a+q            s ++ +l+ + +++ +ys
  EFC37685.1  91 CLTEEDSEILNCYYSSSMFLHVIARQelerflqdsssNSSKANTLEMIEMMTLYYS 146
                 ***************99999999999899999996663334444444445555555 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0011
                 HHHHHHHHHHHHHHHHHT---S-HHHHHHHHHHHHHSSSGGGTTTTS..SS-SSSSS-STTHHHHHHHHHHHHHHHHHHTTH............HHHHH CS
      APC1_C  51 lLplylslykllqtlakqssaaslalwdlrlvlefyssearlsalgaaeeksresLlrpsllesleqrvdalldswgkegsa............kllsr 137
                 ++++++ ++ ll++++k++  +    ++l+l+ +f +s   l  l    + s+++ + +  +es ++r+ +++++ ++e++              +l+r
  EFC37685.1 296 CMQVHMLILTLLRDCKKYEEDTKGRSENLTLLYDFLESGITLALLS---KCSEKTPMIEYTIESSAKRIVKSIKNPNFESAPfeviiylsfaaeHHLKR 391
                 7899**************999*******************999988...45777777778889999999999999999988888888888888878888 PP

                 HHS-. CS
      APC1_C 138 ylrsg 142
                  l++ 
  EFC37685.1 392 ILQGV 396
                 77764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      275  (0.0153383); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2779.55
//
Query:       EFC37686.1  [L=554]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.6e-08   32.8  11.0    1.8e-07   31.2  11.0    2.0  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
      0.033   14.3   0.0      0.064   13.4   0.0    1.4  1  CD225     Interferon-induced transmembrane protein


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2  11.0     2e-11   1.8e-07       2      39 ..     153     190 ..     152     191 .. 0.90

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 2e-11
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 +Cd Cr+ +++Cd+ +P+C+ Ck ++ +C + +++++r
  EFC37686.1 153 SCDACRSNHRRCDRIRPSCQACKIRGIPCNYSMNFKRR 190
                 8*****************************66666655 PP

>> CD225  Interferon-induced transmembrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   7.1e-06     0.064      23      52 ..     247     276 ..     245     279 .. 0.94

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 7.1e-06
       CD225  23 vAlvySvkvrdrkmvGdvegAqsasstAkl 52 
                 +Al+yS+k+    ++G++++A+ ++++Ak 
  EFC37686.1 247 IALYYSIKATCECQMGQIDKAELSAKQAKE 276
                 9***************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (554 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1092  (0.0609069); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 3450.10
//
Query:       EFC37687.1  [L=674]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.6e-50  170.3  16.5    9.2e-50  169.8  16.5    1.1  1  ABC_membrane     ABC transporter transmembrane region
    1.7e-35  122.5   0.0    1.2e-34  119.7   0.0    2.2  2  ABC_tran         ABC transporter
    9.9e-06   25.1   2.5    0.00058   19.4   0.1    2.3  2  SMC_N            RecF/RecN/SMC N terminal domain
    0.00098   18.5   0.0     0.0021   17.4   0.0    1.4  1  Zeta_toxin       Zeta toxin
     0.0023   18.3   0.1      0.011   16.1   0.1    2.1  2  AAA_16           AAA ATPase domain
     0.0031   17.2   0.2     0.0075   16.0   0.2    1.6  1  AAA_29           P-loop containing region of AAA domain
     0.0066   16.2   0.0      0.011   15.4   0.0    1.4  1  AAA_24           AAA domain
     0.0097   16.2   0.3       0.11   12.7   0.3    2.3  1  AAA_22           AAA domain
  ------ inclusion threshold ------
      0.037   13.8   0.0        0.1   12.3   0.0    1.7  1  AAA_30           AAA domain
      0.042   12.7   0.0      0.085   11.6   0.0    1.4  1  ABC_ATPase       Predicted ATPase of the ABC class
       0.05   13.5   0.0       0.11   12.4   0.0    1.5  1  RsgA_GTPase      RsgA GTPase
      0.079   12.7   0.0       0.14   11.9   0.0    1.4  1  AAA_15           AAA ATPase domain
       0.15   12.0   0.0          1    9.4   0.0    2.2  2  AAA_5            AAA domain (dynein-related subfamily)
        3.1    8.3   6.5          2    8.9   3.1    2.5  2  Phage_holin_6_1  Bacteriophage holin of superfamily 6 (Holin_


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.8  16.5   7.2e-53   9.2e-50       1     272 [.      84     363 ..      84     365 .. 0.95

  Alignments for each domain:
  == domain 1  score: 169.8 bits;  conditional E-value: 7.2e-53
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHH......HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHH CS
  ABC_membrane   1 liliillailagvlsplfplvlgrildtlldkgdpet......ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsf 91 
                   +il+il ++ +gv++++f +++g +++++ + +           a++ ++l ++++++++ ++++++++++ +++er+   lr+ +f+ + rq+++f
    EFC37687.1  84 IILGILGSMGNGVVALIFQFIFGDLINIFQPVNGVMPsatimrNAISDVCLKFTGVAIGSMASSFVSQFFNGWASERIGISLRQAYFNELTRQEVAF 180
                   6899*************************998544446799999***************************************************** PP

                   HHHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane  92 fdtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEsls 188
                   fd +++G l+  l++dv k+++++++k++ ++q  +t+++gli++f+++w++tlv+++++pl+il+ +v++k+++k++ k  +++ak+ s a+E++s
    EFC37687.1 181 FDIKKTGALTIALSEDVGKIQEAWTRKISGVMQHTSTILIGLILAFVSSWQMTLVTISTTPLMILIGVVMGKLTEKISFKSGETIAKSASKATEVVS 277
                   ************************************************************************************************* PP

                   THHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHH..HHHHHHHHHHH CS
  ABC_membrane 189 girtVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlv..vflslfailfg 272
                    ++tVk++g ee+++ +f + l++ +  gi ka a+g++ g   +++   ++la+w+++ lv +g++ +gdlv  + l++f+++++
    EFC37687.1 278 SFKTVKSMGCEEKEQAQFANILKKLHLYGILKAGAQGASLGSESFIIWGTCSLAFWYAGNLVVDGTIVIGDLVkvFGLLIFSVFSM 363
                   ***********************************************************************753245555666666 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.88   1.1e+03      66      99 ..     255     309 ..     184     321 .. 0.67
   2 !  119.7   0.0   9.7e-38   1.2e-34       1     137 []     426     577 ..     426     577 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.88
                 SS--S-TTSBHHHH.....................HHHTCHHHHHHHSTTGGTTC CS
                 xxxxxxxxxxxxxx.....................xxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  66 qepqlfpeltvren.....................esdeeiekalsklglkelkd 99 
                 ++ +++++ t++++                     +++++++++l+kl l ++ +
  EFC37687.1 255 EKISFKSGETIAKSaskatevvssfktvksmgceeKEQAQFANILKKLHLYGILK 309
                 3333333333333334444444444444445555577888889999988877665 PP

  == domain 2  score: 119.7 bits;  conditional E-value: 9.7e-38
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH...............HHHTC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...............xxxxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren...............esdee 84 
                 l++ +l++k g+ +a+vG++G+GKSt++ ll + ++p+eG + +dg d+ke++ ++l+k++g+++qep lf  + ++en               e    
  EFC37687.1 426 LQDFTLNVKTGQSIAMVGPSGSGKSTIVGLLERFYDPEEGVVSIDGVDIKEIDPKWLHKNVGIVTQEPVLFACT-IKENiayavglenvtdkdiE---- 519
                 68999******************************************************************999.************96665552.... PP

                 HHHHHHHSTTGG.......TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  85 iekalsklglke.......lkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                   +a++  + ++         +t +++++ sLSgGqkqrva+arall++pk+lllDE+t+
  EFC37687.1 520 --QAAKAANCHNfildlpnGYNTLLGEKGVSLSGGQKQRVAIARALLQNPKILLLDEATS 577
                 ..444443333333333336699***********************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.4    0.0085        11      26      41 ..     438     453 ..     427     457 .. 0.81
   2 !   19.4   0.1   4.5e-07   0.00058     111     213 ..     506     621 ..     457     627 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0085
                 EEEEEESTTSSHHHHH CS
                 xxxxxxxxxxxxxxxx RF
       SMC_N  26 ftaivGpNGSGKsnll 41 
                   a+vGp GSGKs ++
  EFC37687.1 438 SIAMVGPSGSGKSTIV 453
                 4589*********997 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 4.5e-07
                 EEETTEEE-HHHHHHHHHCTT-STT.................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxx.................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 111 ykingkevtkkevsellesagiske.................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQf 192
                 y++  ++vt k++++  + a+ +                   +LSgG+k+ va+a        +   + llDe  +aLD +  + v   l+   k    
  EFC37687.1 506 YAVGLENVTDKDIEQAAKAANCHNFildlpngyntllgekgvSLSGGQKQRVAIARA----LLQNPKILLLDEATSALDTESEALVQAALEMLMKGRTS 600
                 4444445555555555544444444777777777777777779*******9998754....344556899***************************** PP

                 EEE-SSHHHCCC-SCEEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 193 ivislreemlekadklvgvtk 213
                 i i++r  +++++d ++ + k
  EFC37687.1 601 ISIAHRLSTVQNCDVIYVLVK 621
                 **************9987665 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   1.6e-06    0.0021      15      61 ..     435     481 ..     424     494 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.6e-06
  Zeta_toxin  15 rPklillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPey 61 
                 +  +i ++G +G+GKs++  ll++  +++++vv +d+ d++e  P+ 
  EFC37687.1 435 TGQSIAMVGPSGSGKSTIVGLLERFYDPEEGVVSIDGVDIKEIDPKW 481
                 556899************************************99985 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       2.9   3.7e+03      78     107 ..     185     220 ..     146     311 .. 0.56
   2 !   16.1   0.1     9e-06     0.011      19      58 ..     433     471 ..     422     603 .. 0.53

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.9
      AAA_16  78 reellrqlldeaesaeleawrekleeala......a 107
                 + + l+  l+e+  + +eaw +k+ ++++      +
  EFC37687.1 185 KTGALTIALSEDVGKIQEAWTRKISGVMQhtstilI 220
                 446666666666666677777766666664433330 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 9e-06
      AAA_16  19 vrsgrpelvllsGesGvGKsslvrellralekdggif.lrg 58 
                 v++g  +++  +G+sG+GKs++v  l r +  ++g++ + g
  EFC37687.1 433 VKTG--QSIAMVGPSGSGKSTIVGLLERFYDPEEGVVsIDG 471
                 5555..68999****************99999965554333 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.2   5.9e-06    0.0075      16      39 ..     430     453 ..     423     457 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5.9e-06
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                 t+++++ +++ ++GpsGsGKST++
  EFC37687.1 430 TLNVKTGQSIAMVGPSGSGKSTIV 453
                 55666555999***********97 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   8.9e-06     0.011       2      72 ..     436     533 ..     435     556 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 8.9e-06
      AAA_24   2 klkiliyGpsgiGKTtlakelgpkplfidtekGlksldadkfpdie..............................swedfldevvelaaeladyktlv 70 
                 +++i+++Gpsg+GK+t++  l +   f d e+G+ s+d+ ++++i                               ++e++ d+  e aa+ a+++  +
  EFC37687.1 436 GQSIAMVGPSGSGKSTIVGLL-E--RFYDPEEGVVSIDGVDIKEIDpkwlhknvgivtqepvlfactikeniayavGLENVTDKDIEQAAKAANCHNFI 531
                 6799*****************.5..589***************99887777766666666665555444444333333333333333377777777777 PP

      AAA_24  71 iD 72 
                 +D
  EFC37687.1 532 LD 533
                 77 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.3     9e-05      0.11       4      33 ..     435     464 ..     431     604 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 9e-05
      AAA_22   4 tagilvvtGesGtGKTtllrrlleqldeea 33 
                 t ++++ +G+sG+GK+t +  l + +d e+
  EFC37687.1 435 TGQSIAMVGPSGSGKSTIVGLLERFYDPEE 464
                 7899***************99999997543 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0     8e-05       0.1      20     112 ..     438     590 ..     429     598 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 8e-05
      AAA_30  20 vavltGpAGtGKttalkalreaweaa.g.........................grviglApt..gkaAkvLa........eelgieastiakllkrlk. 81 
                   +++Gp G+GK+t+++ l++ ++ + g                         ++ +++A t  ++ A +++         e  ++a++ ++++  l  
  EFC37687.1 438 SIAMVGPSGSGKSTIVGLLERFYDPEeGvvsidgvdikeidpkwlhknvgivtQEPVLFACTikENIAYAVGlenvtdkdIEQAAKAANCHNFILDLPn 536
                 56789******************9996688888888888888888877777773333333330033333333222222111222355555555544448 PP

      AAA_30  82 .......................grarlepgtllivDEagmvdtkqlaallkaa 112
                                        +ra l++ ++l+ DEa  +  ++ +al++aa
  EFC37687.1 537 gyntllgekgvslsggqkqrvaiARALLQNPKILLLDEATSALDTESEALVQAA 590
                 888999999999999998888886677777789999998888777778887776 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   6.6e-05     0.085     299     353 ..     524     579 ..     517     626 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.6e-05
                 EE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS-H CS
  ABC_ATPase 299 gvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsAt 353
                  ++  +Fi +LP+g +t         SG   q ++i++al  + k+lL+DE tsA 
  EFC37687.1 524 AANCHNFILDLPNGYNTLlGEKGVSLSGGQKQRVAIARALLQNPKILLLDEATSAL 579
                 678899***********955566678****************************95 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   8.8e-05      0.11      96     120 ..     432     457 ..     408     471 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 8.8e-05
                  HCTT.SEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  96 llkd.ktsvlvGqSGvGKStLinall 120
                  ++k  + +++vG+SG GKSt++  l 
   EFC37687.1 432 NVKTgQSIAMVGPSGSGKSTIVGLLE 457
                  44444999*************98886 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00011      0.14      15      79 ..     427     488 ..     425     585 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
      AAA_15  15 kdveidlsee.ltvliGkNnsGKSsilealdlFlnnkekknkkvikiekedleifeniseskdikI 79 
                 +d++++++       +G+ +sGKS+i+ +l+ F + +    + v+ i+  d+++ + +   k++ I
  EFC37687.1 427 QDFTLNVKTGqSIAMVGPSGSGKSTIVGLLERFYDPE----EGVVSIDGVDIKEIDPKWLHKNVGI 488
                 666666666656789********************98....6666666666666655544444444 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0    0.0008         1       3      23 ..     440     460 ..     438     470 .. 0.84
   2 ?   -0.7   0.0      0.98   1.3e+03      63      79 ..     564     580 ..     537     624 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0008
                 EEE--SSSSHHHHHHHGGGGB CS
       AAA_5   3 lLvGppGtgKselaerlaaal 23 
                  +vGp+G+gKs+++  l +++
  EFC37687.1 440 AMVGPSGSGKSTIVGLLERFY 460
                 58*************999887 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.98
                 --G-SEEEEESGGG--H CS
       AAA_5  63 aregeilvlDEveraes 79 
                  ++++il+lDE + a +
  EFC37687.1 564 LQNPKILLLDEATSALD 580
                 34899999999887653 PP

>> Phage_holin_6_1  Bacteriophage holin of superfamily 6 (Holin_LLH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   3.1    0.0016         2       6      83 ..     235     310 ..     208     322 .. 0.71
   2 ?   -1.9   0.1       3.6   4.6e+03      74      95 ..     503     525 ..     494     526 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0016
  Phage_holin_6_1   6 vsvlviiitivlgllvkkikkllklkkqgekakkiaeiaknaVkaveqvake.dakgeeKkeeAleklkellkekgi.si 83 
                      v+++++ + i++g++  k+ ++     +++  ++ia+ a +a+++v   ++  ++ +eeK +  + +++++l+ +gi ++
       EFC37687.1 235 VTISTTPLMILIGVVMGKLTEK----ISFKSGETIAKSASKATEVVSSFKTVkSMGCEEKEQAQFANILKKLHLYGIlKA 310
                      3333333444444444444433....34455578999999999999988887789*********************9665 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 3.6
  Phage_holin_6_1  74 ellkekgi.sitddeleglIEaa 95 
                      +++  +g+ ++td+++e + +aa
       EFC37687.1 503 NIAYAVGLeNVTDKDIEQAAKAA 525
                      56667889999999998887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (674 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1002  (0.0558871); expected 358.6 (0.02)
Passed bias filter:                      621  (0.0346366); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.79u 0.34s 00:00:01.13 Elapsed: 00:00:00.49
# Mc/sec: 4137.56
//
Query:       EFC37688.1  [L=518]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.2e-65  220.6   0.2    8.1e-65  218.8   0.1    1.9  2  Pkinase         Protein kinase domain
    5.2e-34  117.7   0.0    9.2e-34  116.9   0.0    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
    1.4e-05   24.3   2.2    2.6e-05   23.4   2.2    1.5  1  Haspin_kinase   Haspin like kinase domain
     0.0022   17.6   0.5      0.005   16.4   0.5    1.7  1  RIO1            RIO1 family
      0.003   16.9   0.0      0.006   15.9   0.0    1.5  1  Kinase-like     Kinase-like
     0.0095   14.8   0.0     0.0095   14.8   0.0    1.5  2  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.018   14.4   0.1      0.035   13.4   0.1    1.4  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
      0.092   12.9   1.3       0.16   12.1   1.3    1.5  1  Transposase_24  Plant transposase (Ptta/En/Spm family)
       0.19   11.4   0.1       0.19   11.4   0.1    2.2  2  FTA2            Kinetochore Sim4 complex subunit FTA2
          3    7.9  11.7       0.48   10.5   2.0    2.8  2  DUF5094         Domain of unknown function (DUF5094)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       0.4   7.2e+02     157     195 ..      61     103 ..      27     143 .. 0.73
   2 !  218.8   0.1   4.5e-68   8.1e-65       1     264 []     175     464 ..     175     464 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.4
                 TTSCGGGS-HHHHTTSCB....SHHHHHHHHHHHHHHHHHSS- CS
     Pkinase 157 fvgtseYlAPEvlkeney....skkvDvWslGvilyelltgkp 195
                 +  +++Y AP  +++n+       +  ++s   +l++++ +kp
  EFC37688.1  61 EEEDEYYTAPASVSSNQSqaaaNDTNNIYSPSTVLASIVQQKP 103
                 5567899999999554441012445568888888888877765 PP

  == domain 2  score: 218.8 bits;  conditional E-value: 4.5e-68
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHS.CTTB--EEEEEEE.....SSEEEEEEE--TTEBHHHHHHHH CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklk.hpnivrlyevfee.....kdelylvleyveggeladllerk 92 
                 ye +e +G+G++G V++av+k  +++vA+Kki+   +k+k   k+++rEikil ++k hpniv++++ +        +++y+v+ey++++ l++ll+  
  EFC37688.1 175 YEPIECVGKGAYGIVISAVDKLMNRKVAIKKIEAVFKKEKFFqKRIMREIKILIHCKgHPNIVEILDLVPPesfdeFEDIYIVTEYMDCN-LQELLKSG 272
                 677889****************************9998887679**********************976655555599**********98.******99 PP

                 SS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHHH CS
     Pkinase  93 gslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl.keneyskkvDvWslGvilyel 190
                 +++se++++ +++q+l++l+ lH+  i+HrD+K++NiL++++ e+K +DFGl++ + +++  t+ v+t++Y++PE+l k+++ +k++DvWslG++++el
  EFC37688.1 273 QKFSEQNIQYFLYQMLKALDVLHNCDIVHRDIKSSNILVNNDYEVKFCDFGLSRAMMNEKMSTDNVATRWYRSPELLlKYHKAGKPIDVWSLGCVFAEL 371
                 99**********************************************************9****************999******************* PP

                 HH...SS-STTTSSHHHHHHHHHHTHHHHHHHCT.........SHH...HHHTTS........................-HHHHHHHHHHT-SSGCCST CS
     Pkinase 191 lt...gkppfsgekgkekvekeldqlekilkilg.........etkeklpeasei........................seeakdllkkllkkdpkkRl 253
                 l+   ++ +f+ge+       +l+q+ kil+ilg         +          +                        ++ea+dll+k+l+  p+kR+
  EFC37688.1 372 LStpkQHVLFPGES-------HLNQIDKILDILGtplpedvfgC----------FkaqvymsnqpyrkrkdfkklfpdaNPEALDLLEKMLEFSPEKRI 453
                 97333567788443.......55555557777764443333332..........033334555557778889999************************ PP

                 THHHHHTSGGG CS
     Pkinase 254 taeellqhpyl 264
                 t+++ l++pyl
  EFC37688.1 454 TVSDSLRQPYL 464
                 *********97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  116.9   0.0   5.2e-37   9.2e-34       5     205 ..     179     378 ..     176     460 .. 0.86

  Alignments for each domain:
  == domain 1  score: 116.9 bits;  conditional E-value: 5.2e-37
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH..HHHHHHHHHHHHTS.-BTTB--EEEEEE.....SSSSEEEEEE--TTEBHHHHHHH CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateee..keelleeakimkkl.khpnivkllgvct.....keepllivteyvkgGdLlkfLrk 94 
                  + +G+Ga+G V+++  k      + kVa+K++++  ++e+  ++++++e+ki+ ++  hpniv++l ++      + e ++ivtey++  +L++ L++
   EFC37688.1 179 ECVGKGAYGIVISAVDK----LMNRKVAIKKIEAVFKKEKffQKRIMREIKILIHCkGHPNIVEILDLVPpesfdEFEDIYIVTEYMDC-NLQELLKS 271
                  568***********988....8899*******99999888889*************99***********9665555566********97.8*****99 PP

                  TCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS.-HHHH.HHSEEEHHHHHHH CS
  Pkinase_Tyr  95 kekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWm.apEsl.kekkftsksDvWs 190
                     +k++ +++  f +q+ k+++ L++ ++vHrd+ + N+L++++  vk +DfGL+r++++    +k ++ ++  +W+ +pE l k++k  +  DvWs
   EFC37688.1 272 G--QKFSEQNIQYFLYQMLKALDVLHNCDIVHRDIKSSNILVNNDYEVKFCDFGLSRAMMN----EKMSTDNVATRWYrSPELLlKYHKAGKPIDVWS 363
                  7..9*******************************************************44....444556788888879**862566688999**** PP

                  HHHHHHHHHTTSSGT CS
  Pkinase_Tyr 191 fGvllwEiftlgesp 205
                   G +  E++++ ++ 
   EFC37688.1 364 LGCVFAELLSTPKQH 378
                  *********987765 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   2.2   1.4e-08   2.6e-05      38     260 ..      82     331 ..      16     342 .. 0.67

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 1.4e-08
  Haspin_kinase  38 ssssnkislPvkdqvsrdkikkklrnsesllsln.sqeev.kdfdevilsqilelckikkilneadlasllnd....................... 108
                     + +n+i +P    v+ + +++k+++ +    +   q++v +++d+ + ++ ++++ ++    e+ ++ +l++                       
     EFC37688.1  82 ANDTNNIYSPST--VLASIVQQKPDDCSPNNTFFyGQQPVnQQHDDLMNTSAVNNSSMRDE--EEFYVDTLENhplasdspqvehyiegvqfllpv 173
                    445566666644..44677777777665444443033444677777777777777777432..222333333334555577777788888888888 PP

  Haspin_kinase 109 ........seklssevyqtke..kdkevvlKviplevledvtiskelslkelkslklvkgtypglllllqdkvlkekpdfyseqqlflvlllkdkG 194
                            +++ ++ v  + +  ++++v++K+i   v +  +  +   + e k l  +kg  p+++ +l d v  e+  f  ++   ++++ +++ 
     EFC37688.1 174 ryepiecvGKGAYGIVISAVDklMNRKVAIKKIEA-VFKKEKFFQKRIMREIKILIHCKGH-PNIVEIL-DLVPPES--F--DEFEDIYIVTEYMD 262
                    88888888777777777777667789999999988.555555555566799*********9.7776554.5666666..2..33334455555555 PP

  Haspin_kinase 195 tdLeev....klkswkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRlesse 260
                     +L+e+    +  s ++++  ++q++k L v   + +  HRd++  niLv++  +v ++d+ lsR+  +e
     EFC37688.1 263 CNLQELlksgQKFSEQNIQYFLYQMLKALDVL-HNCDIVHRDIKSSNILVNNDYEVKFCDFGLSRAMMNE 331
                    5555554435666778899999*******999.5789****************************98333 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.5   2.8e-06     0.005      83     152 ..     256     325 ..     195     336 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.8e-06
                 EEEE--EETTEEGGBHHHCG-..HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETT.EEEE--GTTE CS
        RIO1  83 lvmefigedgvaapklkdvee..eeeaeelyeevleemrklykeaglvHaDLSeyNvlvded.kvviIDvsQa 152
                 +v e+++ +  ++  lk  ++  e++++  ++++l+++ +l  ++ +vH D+   N+lv++d +v + D++ +
  EFC37688.1 256 IVTEYMDCNLQEL--LKSGQKfsEQNIQYFLYQMLKALDVLH-NCDIVHRDIKSSNILVNNDyEVKFCDFGLS 325
                 6667776333332..333333448899999999999877776.**************************9755 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   3.4e-06     0.006     144     239 ..     278     367 ..     198     375 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 3.4e-06
  Kinase-like 144 iarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvl...sevekgfaPpEllgsrggytrknktkmthkldaWqlGl 238
                     ++   q+++    L++  +vh ++++ n+l +++  ++  +f+ L ra  + ++   +   + +  pEll +   y++        ++d+W lG 
   EFC37688.1 278 QNIQYFLYQMLKALDVLHNCDIVHRDIKSSNILVNNDYEVKFCDFG-LSRAMMNEKMstdNVATRWYRSPELLLK---YHK-----AGKPIDVWSLGC 366
                  2223334788899999*****************************7.4444433333112445599*******99...766.....67799*****98 PP

  Kinase-like 239 v 239
                  v
   EFC37688.1 367 V 367
                  7 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.7       1.5   2.7e+03     196     230 ..      29      64 ..      13     142 .. 0.49
   2 !   14.8   0.0   5.3e-06    0.0095     312     349 ..     284     315 ..     274     355 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.5
  Pkinase_fungal 196 ergvegvarlvahedve.ekdddiaeiRkgldvtka 230
                     +r+ + + ++ +++++  ++++ + +  ++ + +++
      EFC37688.1  29 NRQQQYITTFKHDKEIIqKHQEAYYDYEDNGEEEED 64 
                     333333333333333321222222222222222222 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 5.3e-06
  Pkinase_fungal 312 lrDaIkghrsLflkagiLHrDiSenNilitdskkeger 349
                     l++ +k++  L+ ++ i+HrDi   Nil++++      
      EFC37688.1 284 LYQMLKALDVLH-NCDIVHRDIKSSNILVNND-----Y 315
                     66788999****.****************944.....3 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1     2e-05     0.035      94     182 ..     256     337 ..     248     355 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2e-05
         Kdo  94 llterlegaqdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldkarlrlradrwrekd 182
                 ++te ++   +L++ll+++++++e+  +  l +  ++   lh+ ++ H+d+   nil++++     e+ + D+  +r  + +++ +  +
  EFC37688.1 256 IVTEYMD--CNLQELLKSGQKFSEQNIQYFLYQMLKALDVLHNCDIVHRDIKSSNILVNNDY----EVKFCDFGLSRAMM-NEKMSTDN 337
                 7777777..36888888888899************************************998....88888998877776.66655555 PP

>> Transposase_24  Plant transposase (Ptta/En/Spm family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.3     9e-05      0.16      48     123 ..      17      92 ..       1     139 [. 0.80

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9e-05
  Transposase_24  48 keleeek.gktpdraevfieTHtkkDGtyvdekaeeiaekvkerlqeresesesetsaesdgssrl.iedkneiflqv 123
                     +++e+++  +  +r + +i T  k+D++ + +k +e + +++++ +e+e+e  +  +++s+++s++ ++d n i++ +
      EFC37688.1  17 QQQEQKLsASMENRQQQYITTF-KHDKE-IIQKHQEAYYDYEDNGEEEEDEYYTAPASVSSNQSQAaANDTNNIYSPS 92 
                     3455555566667777777775.55666.57888999999********************999999*********544 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.6      0.47   8.5e+02     116     142 ..      18      49 ..      15      71 .. 0.71
   2 ?   11.4   0.1    0.0001      0.19     175     212 ..     281     323 ..     252     326 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.47
        FTA2 116 eqekklsrkfdaqelevqnsfaket..e...d 142
                 +qe+kls+ +++ +++   +f+++   +   +
  EFC37688.1  18 QQEQKLSASMENRQQQYITTFKHDKeiIqkhQ 49 
                 79999999999999988888887775313321 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.0001
        FTA2 175 vsqlpkllrdlkklhklgIvvrDlkeenyi.....dgkLvDls 212
                 +  l ++l+ l+ lh++ Iv+rD+k++n++     + k++D++
  EFC37688.1 281 QYFLYQMLKALDVLHNCDIVHRDIKSSNILvnndyEVKFCDFG 323
                 344679********************99863333355788887 PP

>> DUF5094  Domain of unknown function (DUF5094)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   2.4      0.16   2.8e+02      56      90 ..      15      49 ..       3      93 .. 0.62
   2 ?   10.5   2.0   0.00027      0.48     138     174 ..     254     290 ..     248     292 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.16
     DUF5094 56 nekqdkdsllkeikdienelieaykeeNeyLrslk 90
                n +q++++l   +++ ++++i+ +k++ e+ ++ +
  EFC37688.1 15 NIQQQEQKLSASMENRQQQYITTFKHDKEIIQKHQ 49
                33334444444555555555555555554444322 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00027
     DUF5094 138 iYkliesknvdlpeyLseeisFekeqlkkFfykvmqi 174
                 iY ++e+  ++l e L+   +F ++ ++ F+y++ ++
  EFC37688.1 254 IYIVTEYMDCNLQELLKSGQKFSEQNIQYFLYQMLKA 290
                 78899****************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (518 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1561  (0.0870656); expected 358.6 (0.02)
Passed bias filter:                      658  (0.0367003); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.55u 0.25s 00:00:00.80 Elapsed: 00:00:00.41
# Mc/sec: 3829.37
//
Query:       EFC37689.1  [L=131]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.8e-09   37.3   0.1    3.9e-09   36.8   0.1    1.2  1  SAM_1       SAM domain (Sterile alpha motif)
    3.6e-06   27.0   0.1    6.8e-06   26.1   0.1    1.4  1  SAM_2       SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
      0.031   14.5   0.2      0.046   14.0   0.2    1.3  1  SAM_Ste50p  Ste50p, sterile alpha motif
      0.044   14.1   0.6      0.094   13.0   0.6    1.7  1  Ish1        Putative stress-responsive nuclear envelope prote


Domain annotation for each model (and alignments):
>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.1   8.7e-13   3.9e-09       1      61 [.      43     102 ..      43     105 .. 0.95

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 8.7e-13
                 CCTTHSSHHHHHHHTTSGGGHHHHHTTTSSHHHHTTSCHHHHHHCTTTSHHHHHHHHHHHH CS
       SAM_1   1 skwsvedVgeWLesiglgqYadlFrageidgdaLlllteddLeklgvtllGHrkkIlyaIq 61 
                 s+w++ed++eW +s ++++  ++F ++  dg++L   t +dL+++g+++ G +k+I  +++
  EFC37689.1  43 SEWTKEDLVEWAKSYKYEDAPEKFLQNDWDGQCLIYVTIQDLLDIGIKK-GEAKSIETRLK 102
                 68***********************************************.******98876 PP

>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   0.1   1.5e-09   6.8e-06       3      52 ..      44      92 ..      42      98 .. 0.92

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 1.5e-09
                GHHHHHHHHHHHHTTTGGGHHHHHHTTCSHHHHHTTSCHHHHHHTTHHHH CS
       SAM_2  3 swsledvaeWLrsiglkqytdnFrdagitgaelllrlteedLkrlGitsv 52
                 w+ ed+ eW +s ++++  ++F+++ ++g + l ++t +dL ++Gi + 
  EFC37689.1 44 EWTKEDLVEWAKSYKYEDAPEKFLQNDWDG-QCLIYVTIQDLLDIGIKKG 92
                6*****************************.8888************874 PP

>> SAM_Ste50p  Ste50p, sterile alpha motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.2     1e-05     0.046       2      52 ..      41      87 ..      40     110 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1e-05
                XTTT--HHHHHHHHHHHHSS-TTSCHHHHHHHTT--CCCHHHHHHHHHHHC CS
  SAM_Ste50p  2 dfdkWstdevvkkvkaeLgleetdplilriRenditGsvLseltLqDCkeL 52
                ++++W+ ++ v++ k+    +  + +++    nd +G+ L  +t+qD  ++
  EFC37689.1 41 NISEWTKEDLVEWAKSYKYEDAPEKFLQ----NDWDGQCLIYVTIQDLLDI 87
                789*************988888888875....9*************97665 PP

>> Ish1  Putative stress-responsive nuclear envelope protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.6   2.1e-05     0.094       3      22 ..      44      63 ..      43      87 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.1e-05
        Ish1  3 tWSdsdLkkWLdshGipvsk 22
                 W+++dL +W +s+++ +++
  EFC37689.1 44 EWTKEDLVEWAKSYKYEDAP 63
                6**************99544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       668  (0.0372581); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.43
# Mc/sec: 907.89
//
Query:       EFC37690.1  [L=331]
Description: calcium/calmodulin-dependent protein kinase-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.2e-76  254.8   0.0      1e-75  254.5   0.0    1.1  1  Pkinase         Protein kinase domain
    9.8e-39  133.2   0.0    1.2e-38  132.9   0.0    1.1  1  Pkinase_Tyr     Protein tyrosine kinase
    2.3e-06   27.1   0.0    1.5e-05   24.5   0.0    2.2  2  Kinase-like     Kinase-like
    2.8e-06   26.9   0.0    6.4e-06   25.7   0.0    1.6  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
    0.00011   22.0   0.1     0.0067   16.1   0.0    2.3  2  FTA2            Kinetochore Sim4 complex subunit FTA2
     0.0018   17.9   0.1     0.0037   16.9   0.1    1.4  1  RIO1            RIO1 family
     0.0068   16.3   0.0          4    7.4   0.0    2.4  2  COX_ARM         COX Aromatic Rich Motif
  ------ inclusion threshold ------
      0.011   14.5   0.1      0.037   12.8   0.0    1.7  2  Pkinase_fungal  Fungal protein kinase
      0.014   15.3   0.0       0.13   12.1   0.0    2.0  2  APH             Phosphotransferase enzyme family
      0.079   12.5   0.1       0.13   11.8   0.1    1.3  1  Peptidase_M1    Peptidase family M1 domain
        0.1   12.5   0.1       0.26   11.2   0.0    1.7  2  DUF433          Protein of unknown function (DUF433)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  254.5   0.0   6.3e-79     1e-75       3     264 .]      22     278 ..      20     278 .. 0.95

  Alignments for each domain:
  == domain 1  score: 254.5 bits;  conditional E-value: 6.3e-79
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS..--HHH CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgs..lseee 99 
                   + lG+G+f+ V +a +k++g++vAvK+i+k + + +k+ ++ +E++ilk+++ +niv+l++v+e+  ++ylv+e++ ggel+d++ +k    +se+ 
  EFC37690.1  22 FGKVLGSGTFSIVREAAQKNDGRKVAVKIIDKTNLEVNKD-SLKTEVSILKSVNDQNIVELIDVYENGMKVYLVMELLTGGELFDRIVNKYPegYSEDV 119
                 6789*****************************9999885.9*********************************************9655445***** PP

                 HHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS- CS
     Pkinase 100 akkiakqilegleylHskgiiHrDlKpeNiLidekge...lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkp 195
                 a +++++i+++++ylHs g++HrDlKpeN++++++g+   +KitDFGlak ++ +  l++ +gt++Y+APEvl++++y+++vD+Ws+Gvily ll+g p
  EFC37690.1 120 AAELIRKIVSSIKYLHSCGVVHRDLKPENLIYSSDGNdsdIKITDFGLAKIADGDFLLKTACGTPNYVAPEVLQNTGYDASVDMWSIGVILYILLCGFP 218
                 *********************************9888899***************99****************************************** PP

                 STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 196 pfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 pf++e++ e +e++++          ++++ +p ++++s++akdl++ ll ++pkkR+t ++ l+hp++
  EFC37690.1 219 PFYSENTPELFEQIING---------DYDFPSPYWDKVSDSAKDLIRHLLVVNPKKRFTPDQTLSHPWI 278
                 ***88888877777776.........99****************************************7 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  132.9   0.0   7.5e-42   1.2e-38       1     251 [.      20     268 ..      20     275 .. 0.90

  Alignments for each domain:
  == domain 1  score: 132.9 bits;  conditional E-value: 7.5e-42
                  EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTT CS
  Pkinase_Tyr   1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkeke 98 
                  le+gk lG+G+f+ V e+  k    ++  kVavK++++++ e +k++l +e++i+k+++ +niv+l+ v+ ++ ++++v+e+++gG+L + + +k  e
   EFC37690.1  20 LEFGKVLGSGTFSIVREAAQK----NDGRKVAVKIIDKTNLEVNKDSLKTEVSILKSVNDQNIVELIDVYENGMKVYLVMELLTGGELFDRIVNKYPE 113
                  6899**************999....9999******************************************************************999 PP

                  TSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE...TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHH CS
  Pkinase_Tyr  99 kltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGv 193
                    + +   +++ ++ + ++yL+s  +vHrdl   N + s+   ++ +ki+DfGLa+    d +   k+ + +p +++apE+l+++ +  + D+Ws Gv
   EFC37690.1 114 GYSEDVAAELIRKIVSSIKYLHSCGVVHRDLKPENLIYSSdgnDSDIKITDFGLAKIA--DGDFLLKTACGTP-NYVAPEVLQNTGYDASVDMWSIGV 208
                  **************************************98665779**********88..6666666666655.8*********************** PP

                  HHHHHHTTSSGTTTTSHHHHHHHHH.HTTEES-BB..TTSBHHHHHHHHHHT-SSGGGS-- CS
  Pkinase_Tyr 194 llwEiftlgespypglkneevlekl.kegkrlekp..ekcpeelyelmkkcweedpeeRpt 251
                  +l+ +++ g  p+ + ++ e++e++ + ++  + p  +k++++ ++l+++ +  +p++R t
   EFC37690.1 209 ILYILLC-GFPPFYSENTPELFEQIiNGDYDFPSPywDKVSDSAKDLIRHLLVVNPKKRFT 268
                  ***8888.99998888777777776477888888855789999999999999999999976 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.45   7.3e+02      11      49 ..      17      55 ..       8      77 .. 0.77
   2 !   24.5   0.0     9e-09   1.5e-05     133     288 .]     109     266 ..      73     266 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.45
  Kinase-like 11 ertlvrgellkkgdrsvvfevkdqetgeplavkvfllps 49
                 ++ l  g++l+ g +s+v e+  ++ g ++avk+   ++
   EFC37690.1 17 KKDLEFGKVLGSGTFSIVREAAQKNDGRKVAVKIIDKTN 55
                 5677789999999*****999999988888888766555 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 9e-09
  Kinase-like 133 krsethkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgg...lmlggftaLvragtkvvlseve..kgfaPpEllgsrggytrknkt 225
                  +++ +  ++  +a+l+   +++  + +L++ g+vh +++++nl++  +g    +++++f+    a     l + +    +  pE+l +         t
   EFC37690.1 109 NKYPEGYSEDVAAELIR--KIVSSIKYLHSCGVVHRDLKPENLIYSSDGNdsdIKITDFGLAKIADGDFLLKTACgtPNYVAPEVLQN---------T 195
                  44444455555555554..679999*********************99854449*****85444444444355553345666666655.........6 PP

  Kinase-like 226 kmthkldaWqlGlviyriwclklPl.tlatee.....akeewkfklck..kipekvkaLlkkfLqlsqedR 288
                   +  ++d W +G+  y + c   P+  + t+e     ++ +++f      k+++  k L++++L ++ ++R
   EFC37690.1 196 GYDASVDMWSIGVILYILLCGFPPFySENTPElfeqiINGDYDFPSPYwdKVSDSAKDLIRHLLVVNPKKR 266
                  77889*****************9984345555111114556688655445999999999999998887777 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   0.0     4e-09   6.4e-06      90     166 ..      89     165 ..      57     171 .. 0.90
   2 ?   -2.6   0.0       1.8     3e+03      52      86 ..     285     319 ..     275     328 .. 0.72

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 4e-09
         Kdo  90 yrAlllterlegaqdLedllakwae.laeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDl 166
                  +  l++e l+g +  + +++k+ e ++e + ++l++++   i+ lh+ gv H+dl + n+    ++ ++  i + D+
  EFC37690.1  89 MKVYLVMELLTGGELFDRIVNKYPEgYSEDVAAELIRKIVSSIKYLHSCGVVHRDLKPENLIYSSDG-NDSDIKITDF 165
                 56689******************99***********************************9999997.7777777777 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.8
         Kdo  52 klgrtravrEfrllkrLeeagvavpkpvaagavkv 86 
                 k +r+ +  E+r  ++ ++ ++ v   +aa+    
  EFC37690.1 285 KNHRPEIIDELRKFNARRKFKITVEAVLAAQKLLG 319
                 46788888898888888888888888888776555 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.1     0.029        47      17      66 ..      13      61 ..       8      80 .. 0.70
   2 !   16.1   0.0   4.1e-06    0.0067     160     204 ..     107     150 ..     101     165 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.029
        FTA2 17 dfsaekdiefleyLgkglhsiVlkv..kirgkeYALKlFrfleaeeleeaee 66
                +++ +kd ef ++Lg+g+ siV ++  k +g++ A+K+  +    +le +++
  EFC37690.1 13 THDIKKDLEFGKVLGSGTFSIVREAaqKNDGRKVAVKIIDKT---NLEVNKD 61
                4677799***************99933445669999976555...3333444 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 4.1e-06
        FTA2 160 IVKelellkeqeelevsqlpkllrdlkklhklgIvvrDlkeenyi 204
                 IV + +    +e +  + ++k+++ +k lh++g+v+rDlk+en+i
  EFC37690.1 107 IVNK-YPEGYSEDVAAELIRKIVSSIKYLHSCGVVHRDLKPENLI 150
                 6666.667788999999**************************98 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.1   2.2e-06    0.0037      42     142 ..      50     154 ..      29     166 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 2.2e-06
                 --GS-HHHHHHHHHHHHHHHHHHHHHTT.--S--EEEEETT.EEEEE--EETTEEGGBHHHCG-...HHHHHHHHHHHHHHHHHHHHTSTEEESS-STT CS
        RIO1  42 ksktnprklvklwaekEfrnLkrleeag.vpvPkpielkrh.vlvmefigedgvaapklkdvee...eeeaeelyeevleemrklykeaglvHaDLSey 135
                    + ++++ k + + E+++Lk +++++ v+  +++e      lvme++   ++    +++++e   e+ a+el ++++++ +k ++ +g+vH DL   
  EFC37690.1  50 IIDKTNLEVNKDSLKTEVSILKSVNDQNiVELIDVYENGMKvYLVMELLTGGELFDRIVNKYPEgysEDVAAELIRKIVSS-IKYLHSCGVVHRDLKPE 147
                 45566778888888999999999998864556666655433259******5555555566666556677788888888885.66677************ PP

                 SEEEETT CS
        RIO1 136 Nvlvded 142
                 N+++++d
  EFC37690.1 148 NLIYSSD 154
                 *999877 PP

>> COX_ARM  COX Aromatic Rich Motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0024         4      33      44 ..     102     113 ..     101     114 .. 0.88
   2 !    6.3   0.0    0.0054       8.8      26      40 ..     220     234 ..     218     235 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0024
                 THHHHHHHHTT- CS
     COX_ARM  33 gLFdsIvnkyme 44 
                 +LFd Ivnky e
  EFC37690.1 102 ELFDRIVNKYPE 113
                 69********87 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0054
                 EES-B-TTHHHHHHH CS
     COX_ARM  26 yFssVdpgLFdsIvn 40 
                  +s+  p+LF++I+n
  EFC37690.1 220 FYSENTPELFEQIIN 234
                 59************9 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.42   6.8e+02     182     206 ..      61      85 ..      23      93 .. 0.78
   2 ?   12.8   0.0   2.3e-05     0.037     313     404 ..     125     213 ..     115     215 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.42
  Pkinase_fungal 182 aerksEaelLkkaeergvegvarlv 206
                     ++ k+E+ +Lk ++++++ ++  ++
      EFC37690.1  61 DSLKTEVSILKSVNDQNIVELIDVY 85 
                     5567999999999999998877665 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 2.3e-05
  Pkinase_fungal 313 rDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhDLES...ffyvl 404
                     r  +   + L+  +g++HrD   +N++     + ++    + D+ lak  +    +   ++  GT++++a evl+++      D+ S   ++y+l
      EFC37690.1 125 RKIVSSIKYLH-SCGVVHRDLKPENLIYS--SDGNDSDIKITDFGLAKIADG---DFLLKTACGTPNYVAPEVLQNTGYDASVDMWSigvILYIL 213
                     56677778899.*************9988..666788999********9995...3344779*************87655554443311156666 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.13     2e+02      22     106 ..      45     135 ..      37     138 .. 0.66
   2 ?   12.1   0.0   8.1e-05      0.13     154     200 ..     121     172 ..     110     175 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.13
                 -EEEEEE-TT...S-HHHHHHHHHHHHHHHHTT-B--B-CTTBS-EEETTEEEEEEE----EE-SS.......HHHHHHHHHHHHHHHHHHCCHH CS
         APH  22 ryvlrrnppa...raaeeirrevallrlLakagvpvPevlagdtddeeigllfalieyvpgrsllr.......klsaaqlpellealgeflaalh 106
                 +++++++ +     ++ ++  ev +l+ ++++++ v e+++  +++   +l+++l+++  g+ ++r         s++++ el++++++ ++ lh
  EFC37690.1  45 KVAVKIIDKTnleVNKDSLKTEVSILKSVNDQNI-V-ELIDVYENGMKVYLVMELLTG--GELFDRivnkypeGYSEDVAAELIRKIVSSIKYLH 135
                 5556664444333478889999999999999988.5.999988888888888888888..66666677665554455555555555555555555 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 8.1e-05
                 HHHHHH--S....SS-EEEE-SS-SGGGEEEC...TTEEEEE---TT-EEEE CS
         APH 154 aalaallpg....elptvllHgDlhpgNllvd.pddgrvtGviDfedaglgp 200
                 a+l +   +      + +++H+Dl+p Nl+   ++++  + + Df++a++++
  EFC37690.1 121 AELIRKIVSsikyLHSCGVVHRDLKPENLIYSsDGNDSDIKITDFGLAKIAD 172
                 4555555555555666789*************97777777899999998765 PP

>> Peptidase_M1  Peptidase family M1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1     8e-05      0.13     121     192 ..      50     118 ..      30     133 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8e-05
                   HHHCHHHHHHHHTSTTHHHSSGG-GSHHHHHHTSSHHHHHHHHHHHHHHHHHCTHHHHHHHHHHHHHHCTTE CS
  Peptidase_M1 121 lleeveealsedaldeshpitqevekpseidevFdsiaYeKGasllrmlekllgeevFqkglksYlkefkyk 192
                   ++++++ ++++d+l+++ +i ++v+++ +i e+ d  +Ye G++++ ++e l+g e F++ +++Y + ++ +
    EFC37690.1  50 IIDKTNLEVNKDSLKTEVSILKSVNDQ-NIVELID--VYENGMKVYLVMELLTGGELFDRIVNKYPEGYSED 118
                   4788889999**********9999966.6777765..7***************************8777665 PP

>> DUF433  Protein of unknown function (DUF433)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00016      0.26      19      51 ..      89     121 ..      85     124 .. 0.91
   2 ?   -4.1   0.0       9.3   1.5e+04      19      26 ..     306     313 ..     304     314 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00016
                 -BTHHHHHHHHTT--HHHHHHHH.TS-HHHHHH CS
      DUF433  19 ipVetilellaaGesieeiledyPdLtlediqa 51 
                 + V+ ++ell  Ge +++i+ +yP+   ed+ a
  EFC37690.1  89 MKVYLVMELLTGGELFDRIVNKYPEGYSEDVAA 121
                 6799*********************99999987 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 9.3
                 -BTHHHHH CS
      DUF433  19 ipVetile 26 
                 i+Ve +l+
  EFC37690.1 306 ITVEAVLA 313
                 67777764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (331 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       843  (0.0470188); expected 358.6 (0.02)
Passed bias filter:                      607  (0.0338558); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2124.46
//
Query:       EFC37691.1  [L=4270]
Description: hypothetical protein NAEGRDRAFT_81845 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   4.7e-162  538.5   0.0   1.7e-159  530.1   0.0    3.4  3  AAA_6            Hydrolytic ATP binding site of dynein motor 
   2.8e-119  398.8  17.6   2.8e-119  398.8  17.6    5.2  6  DHC_N2           Dynein heavy chain, N-terminal region 2
   2.5e-111  371.8   0.1   2.5e-111  371.8   0.1    2.4  2  Dynein_C         Dynein heavy chain C-terminal domain
   5.6e-102  340.5   1.8   3.6e-100  334.6   0.1    3.6  3  AAA_8            P-loop containing dynein motor region D4
    9.6e-66  221.0   7.3    9.6e-66  221.0   7.3    3.3  1  AAA_9            ATP-binding dynein motor region
    9.8e-66  220.7   0.0    1.4e-63  213.7   0.0    3.3  2  AAA_7            P-loop containing dynein motor region
    1.6e-61  206.9   0.1    1.3e-60  203.9   0.0    2.8  2  AAA_lid_11       Dynein heavy chain AAA lid domain
    3.1e-43  146.7   0.0    1.9e-41  140.9   0.0    3.0  2  Dynein_heavy     Dynein heavy chain region D6 P-loop domain
    1.9e-38  132.4  14.6    4.8e-38  131.1  14.6    1.7  1  MT               Microtubule-binding stalk of dynein motor
    2.9e-22   79.1   2.7    9.4e-22   77.5   1.1    3.0  1  Dynein_AAA_lid   Dynein heavy chain AAA lid domain
      9e-20   71.1   0.0    7.2e-07   29.3   0.0    5.8  5  AAA_5            AAA domain (dynein-related subfamily)
    2.7e-16   59.6   0.3    2.1e-15   56.8   0.0    2.8  1  AAA_lid_1        AAA+ lid domain
    2.3e-05   24.7   0.0       0.18   12.2   0.0    4.0  2  RNA_helicase     RNA helicase
    4.5e-05   23.9   0.4        1.3    9.5   0.0    4.5  4  AAA              ATPase family associated with various cellul
    4.5e-05   23.7   0.0       0.14   12.5   0.0    4.1  3  AAA_22           AAA domain
    0.00074   19.9   0.0          3    8.2   0.0    3.8  3  AAA_16           AAA ATPase domain
  ------ inclusion threshold ------
      0.055   13.3   0.1       0.51   10.1   0.1    2.8  1  Methyltransf_31  Methyltransferase domain
       0.12   12.1   0.3        2.9    7.6   0.1    2.9  3  AAA_30           AAA domain
       0.25   11.5   0.7         17    5.6   0.2    3.4  3  AAA_33           AAA domain
       0.59   10.7   0.0       0.59   10.7   0.0    4.6  3  AAA_18           AAA domain


Domain annotation for each model (and alignments):
>> AAA_6  Hydrolytic ATP binding site of dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  530.1   0.0  1.9e-162  1.7e-159       1     327 []    1510    1836 ..    1510    1836 .. 1.00
   2 ?    4.1   0.0     0.021        19      27      57 ..    2172    2202 ..    2152    2205 .. 0.70
   3 ?   -1.6   0.0       1.2     1e+03     205     227 ..    2393    2416 ..    2349    2458 .. 0.66

  Alignments for each domain:
  == domain 1  score: 530.1 bits;  conditional E-value: 1.9e-162
       AAA_6    1 YgyeYlgnserLviTpltdrcyltltqAlklklggapaGpagtGKtEtvkdLakalakqvvvfncsdqldykslgkifkGlaqsGaWgCfdeFnrie 97  
                  YgyeYlgn+erLviTpltdrcy+tlt Al+l  ggap+GpagtGKtEt+kdLaka+ak++vv+ncsd+l+y+s++++f+Gla+sGaW+CfdeFnrie
  EFC37691.1 1510 YGYEYLGNQERLVITPLTDRCYRTLTGALQLFKGGAPEGPAGTGKTETTKDLAKAIAKHCVVYNCSDDLTYESMAQFFRGLASSGAWSCFDEFNRIE 1606
                  9************************************************************************************************ PP

       AAA_6   98 levLSvvaqqiktiqqalkekkkkfvfegkeiklnksvgifitmnpgyagrteLPdnLkalfRpvammvPdlelIaeimLfseGfkeakelakklvt 194 
                  l+vLSvvaqqi+tiq a+++++++f fe+ ei++n++++ifitmnpgyagr+eLPdnLkalfRpvammvPd++lIaei+Lfs Gf e ++la+k+v+
  EFC37691.1 1607 LDVLSVVAQQIQTIQLAVASRATRFFFENMEINMNPTCAIFITMNPGYAGRSELPDNLKALFRPVAMMVPDYALIAEISLFSYGFLEGRKLARKIVS 1703
                  ************************************************************************************************* PP

       AAA_6  195 lykllseqlskqdhydfglralksvlkaagelkreepeeseeelllralrdvnlpklvaeDvplfkglisdlFpgvelpesdyeeleeaieevlkek 291 
                  +y+l+seqls+qdhyd+g+ra+k+vl+ ag+lkr+ p+ +ee+l+lral+dvnlpk+v++D+plf+g+i+dlFp++e +++dy++le+a+ ++++e+
  EFC37691.1 1704 TYRLCSEQLSSQDHYDYGMRAVKAVLVRAGSLKRQFPDLNEEQLMLRALNDVNLPKFVSADIPLFNGIIKDLFPTTEHQKVDYSALENALIQTCAEM 1800
                  ************************************************************************************************* PP

       AAA_6  292 klqleekfvekviqlyetlkvrhgvmlvGetgsgKt 327 
                  +lq+ + f++k+iqlye++ vrhg+mlvG ++sgKt
  EFC37691.1 1801 NLQPVPYFIQKIIQLYEMIIVRHGLMLVGFPMSGKT 1836
                  ***********************************8 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.021
       AAA_6   27 qAlklklggapaGpagtGKtEtvkdLakala 57  
                  + l+        Gp+gtGK+E vk++  +l+
  EFC37691.1 2172 TLLDHGKQPLFVGPTGTGKSEYVKQFLLKLG 2202
                  455555566678************9866665 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 1.2
       AAA_6  205 kqdhydfglralksvlkaagel.k 227 
                  +++hy f+lr l  + + + ++  
  EFC37691.1 2393 EKSHYTFNLRDLSKIFQGVCSVgP 2416
                  678888888888888776666544 PP

>> DHC_N2  Dynein heavy chain, N-terminal region 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   1.3       3.1   2.8e+03      41     163 ..     357     470 ..     317     536 .. 0.57
   2 ?   -0.0   1.4      0.42   3.7e+02       1      28 [.     808     835 ..     761     899 .. 0.46
   3 ?   -1.7   0.1       1.4   1.2e+03       1      58 [.     876     929 ..     876     945 .. 0.69
   4 !  398.8  17.6  3.1e-122  2.8e-119       1     397 []     950    1365 ..     950    1365 .. 0.96
   5 ?   -3.9   0.1       6.3   5.7e+03      96     155 ..    1427    1486 ..    1420    1504 .. 0.75
   6 ?   -3.9   3.4       6.3   5.7e+03      16      90 ..    2806    2875 ..    2733    2929 .. 0.56

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.1
                 XXXXXXXXXXXXXXXXX.XXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXX CS
      DHC_N2  41 leeevkellkklkklpk.alke..wevakelkekieefkevlplieelrnpalrerHwkelsellgvikdpdseesltlgdllelglleeeieeisekA 136
                 +e+    ++ ++k++ k ++ke  +  + + +e+ e+++++l++ eelr+ +++       s  ++    p + +   ++d++e +++   +  i++  
  EFC37691.1 357 IEK----YVDEAKEHYKiSMKEaiFLYYLNSREEYEKYEKYLWCKEELRKNNMTA----PCSGVIE---VPAY-NYQAIHDIIEQNIFYTHLDLITAMH 443
                 333....333444444444444446777788999999999999999999999973....2222221...1111.1224555666666555555555555 PP

                 XX-HHHHHHHHHHHHHHTS---EEEE- CS
      DHC_N2 137 tkEaslekalkkieeewkelefeltey 163
                 +   +l   lk ++e+ k++ + +t++
  EFC37691.1 444 NIHSQLFILLKSLKEDGKSMDLITTQK 470
                 555555555555555555555555554 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.42
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
      DHC_N2   1 leeikkelellkklwdlvsewqekleew 28 
                 l+++ ke+e l++ + +v++    l+++
  EFC37691.1 808 LTDCTKEIERLQSQFATVKSSVHLLSDF 835
                 2334444444444444444444433333 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.4
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXX.XXXXXXXXXXXXXXXXXXXXXX CS
      DHC_N2   1 leeikkelellkklwdlvsewqekleewkktpfkel.dveeleeevkellkklkklpka 58 
                 ++e+++++++l +  dl++++ e++  +     ++l ++++  e+vk++++kl++ +k+
  EFC37691.1 876 MDELQRDINNLLSNLDLYEKIIERFAVF-----DDLeKTDQYYEKVKDMESKLEEAKKN 929
                 5778888888888888888888888777.....66666667777777777766555443 PP

  == domain 4  score: 398.8 bits;  conditional E-value: 3.1e-122
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
      DHC_N2    1 leeikkelellkklwdlvsewqekleewkktpfkeldveeleeevkellkklkklpkalke.....wevakelkekieefkevlplieelrnpalre 92  
                  l++++k+++++ +lw+++ e  +++ +w++++f++ld++ ++e ++ ++++lk+l+k+l+      + +++++k+++  f+ ++pli++lr+++lr+
  EFC37691.1  950 LKDLEKNFKPYFDLWRIAYEKAQNFPKWNEGTFMNLDAKFIDESLSMWQSTLKNLEKNLQPkdetaRIITRQVKKEVVAFLLHMPLINALRKDGLRQ 1046
                  6899******************************************************99999998999999************************* PP

                  XXXXXXXXXX....X....XXXXXXX.XXXXXXXXXXX....XXXXXXXXXXXXXX-HHHHHHHHHHHHHHTS---EEEE-SSS.TEEE..THHHHH CS
      DHC_N2   93 rHwkelsellgv..i....kdpdseesltlgdllelgl....leeeieeisekAtkEaslekalkkieeewkelefelteykdsgvfilkgvdeiie 179 
                  rHw+++ +l     +     d++s + ++lgd+ ++g     + e+i +is+ A+kEa++ k+l+k+ + wk+++f+l++y    ++ l ++de++ 
  EFC37691.1 1047 RHWQKIAKLPLEfgKstaqLDIESINIMNLGDFTKIGFeekpILEKIIDISTLAEKEAEISKNLEKMYSAWKNVNFHLEKYGI--TYKLVELDELQV 1141
                  ********8633342677777999999***********865449*************************************65..59999******* PP

                  HHHHHHHHHHHTCSSSTT..THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT.THHHHHHTHHHHHHHHHHHHHHHHHHHHHHTTSGGGG... CS
      DHC_N2  180 lledhivklqsmksspyvkpfeeeveewekklsrlqeildewlkvQrkWlyLepifssedirkqlpeeakrFksvdkewkkimkevskdpnvleats 276 
                  ll+++iv +q m++spyvk++e+ev +we+kl + q+i++ew+k+Q  +lyLepifss+di++qlp+ea++F  vdk wk++m+ ++k + v +++s
  EFC37691.1 1142 LLDEQIVLTQGMRASPYVKELETEVIAWENKLLERQDIMTEWIKCQVAYLYLEPIFSSQDISAQLPDEATKFGMVDKMWKNVMEVTNKVKVVAQVVS 1238
                  ******************99******************************************************************99988888999 PP

                  STTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSTTHHHH-HHHHHHHHHTTTTSGGGHHHHHHHHSSEEEESE.....EEEEEETTS-EEEEE.... CS
      DHC_N2  277 kpgllekleelneqlekiqksLneyLekkRlafpRFyFlsddeLleilsqskdpsavqphlkkcFegiaslefeekkeitgmiskegEkvelse... 370 
                  ++++++++e++n++le+i+ +L++yLe+kR+afpRFyFlsddeLleils++kdp +vqphlkkcFegi++lef+++ +i++m sk+gE++++++   
  EFC37691.1 1239 DENMRDNFETANKRLEQIHFGLKQYLETKRRAFPRFYFLSDDELLEILSETKDPLRVQPHLKKCFEGIERLEFDKEGKIVAMLSKQGERIPFQKhvi 1335
                  ********************************************************************************************99999 PP

                  ....E.EEEHHHHHHHHHHHHHHHHHHHHH CS
      DHC_N2  371 ...argnveeWLneleeemkktlkellkea 397 
                      +g ve WL e+e+emk +l+++++++
  EFC37691.1 1336 paeKNGRVELWLLEIENEMKGSLRHSIEQS 1365
                  999999********************9985 PP

  == domain 5  score: -3.9 bits;  conditional E-value: 6.3
                  XXXXXXX..XXXXXXXX.XXXXXXXXXXXX.XXXXXXXXXXXXX-HHHHHHHHHHHHHHTS CS
      DHC_N2   96 kelsellgvikdpdseesltlgdllelgll.eeeieeisekAtkEaslekalkkieeewke 155 
                  k l el++ +++ ++ +s+tlg ++ ++++ ++ +  ++++A ++ s  +   +++  w++
  EFC37691.1 1427 KSLIELVR-GENLTALQSITLGAMVVIDVHaRDVVAGLVKEAVGDISDFEWQSQLRYYWED 1486
                  55566664.566788889***********77999999999999987766666666666665 PP

  == domain 6  score: -3.9 bits;  conditional E-value: 6.3
                  XXXXXXXXXXXXX.....XXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
      DHC_N2   16 dlvsewqekleewkktpfkel...dveeleeevkellkklkklpkalkewevakelkekieefkevlplieelrnpal 90  
                  +lv+e +++l++   ++f+ l   ++ e++++v+e++k+l+ l+ +      + el ++ ee+++ +++ ++  n++ 
  EFC37691.1 2806 SLVKEKRTELQTL-RGKFE-LglqRIAETDKDVNEMQKELEILQPN------LIELSKQNEELSKKIEIESQNANEKA 2875
                  4444444444443.22222.11234444444444444444433333......23333333333333333333333333 PP

>> Dynein_C  Dynein heavy chain C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   0.6       9.6   8.6e+03       7      53 ..    3350    3403 ..    3348    3435 .. 0.49
   2 !  371.8   0.1  2.8e-114  2.5e-111       2     307 .]    3941    4267 ..    3940    4267 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 9.6
                  HHHHHHHCCCTTT----....---..CCH--------------..----..... CS
    Dynein_C    7 llstllslqpressssg....sggssreekvlelaadileklpelfdlee...a 53  
                  ll  ++++++++ +s++     ++ + +e++++  ++il+ l    ++e+   +
  EFC37691.1 3350 LLAIVVKIEEKKLESEKnnlaVQNAKYQEQLKHYQDKILQLLQTSRKIEQkqiE 3403
                  555556665554433334555233334668888888888877752233321111 PP

  == domain 2  score: 371.8 bits;  conditional E-value: 2.8e-114
                  HHHHHHHHHHHHCCCTTT----.....---..CCH--------------..----..............-HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Dynein_C    2 keteellstllslqpressssg.....sggssreekvlelaadileklpelfdlee...aekk.pteyeeplntvllqElerfnkLleeirrsLkel 89  
                  +e++ ++++ll++q++++ +++     +++s+++e+++elaadil+klp++f +e    ae k +++y+e++ntv++qEl rfnkLl+ ir+sL++l
  EFC37691.1 3941 TESKLMFDALLTTQQNSAPETNdeddiNENSHETEVLYELAADILTKLPDNFIIEGdggAEAKfKVDYHESMNTVFVQELIRFNKLLNAIRNSLQQL 4037
                  79999******999997644335677756666678**************9887773344445579******************************** PP

                  HC---------HHHHHHHHHHHHTS--GGG.-----SS--HHHHHHHHHHHHHHHHHHH---.....B-GGGSS-HHHHHHHHHHHHHHHTT----- CS
    Dynein_C   90 qkaikGevvmseeleelansllngkvPesWakksypslkplgsWvrdLleRvkqlqkwleeegkPkvfwLsgfffPqaFLtavlqnyarknkipide 186 
                  q+a+kG++vms++le+l +sl+ngkvP  W+k+syps+kpl ++++dL++R++++++w   +gkP+v+wLsgf+f+q+FLt+v+qn+arknki+id+
  EFC37691.1 4038 QLALKGLTVMSSDLEQLSKSLSNGKVPLVWSKASYPSRKPLRTYIQDLIKRIEFFNNWF-IHGKPSVYWLSGFYFTQSFLTGVKQNFARKNKIAIDQ 4133
                  ******************************999**************************.5689********************************* PP

                  EE--EE---..............-EEE-SEEEESSEE..ETTCEE-SS...SEEEES-EEEE-E----T........S..........EEEEEESST CS
    Dynein_C  187 ltfefevtkkekeeea.eeepedGvyihGLfleGarwdkkegvLaesepkelfselPvihlkpveakkk........ekkkkk.....yecPvYkts 269 
                  + fefe+++k  ee++   epe G+y++GLfleGa wd+k+++L++++pk+lf+e+P+i++kpv+++ +             k     y  P+Y+ts
  EFC37691.1 4134 IDFEFEILDKYYEENIsLPEPECGCYVYGLFLEGAAWDRKKKCLTDPRPKQLFDEMPIIWFKPVDRSVEqteptsseV----KtksntYVSPLYRTS 4226
                  ********976655556778888****************************************875444467766541....144567********* PP

                  T--SE..........EEEEEE.......-BHHHTTT-EEES CS
    Dynein_C  270 eRrgvlstt.hstnfvfsvdLptkkp..eehwilrgvalll 307 
                  eRrg+l+tt hstnfv+s++Lp+ ++  e++wi+rg all+
  EFC37691.1 4227 ERRGTLTTTgHSTNFVMSIKLPMASDnnEKYWIKRGCALLC 4267
                  *********************997443377**********9 PP

>> AAA_8  P-loop containing dynein motor region D4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1     0.059        52     185     243 ..    1381    1437 ..    1358    1444 .. 0.82
   2 ?   -3.3   0.0         5   4.5e+03     107     152 ..    1768    1813 ..    1766    1821 .. 0.82
   3 !  334.6   0.1    4e-103  3.6e-100       1     260 []    2531    2807 ..    2531    2807 .. 0.95

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.059
       AAA_8  185 dwfqeWPeeaLleVaekvleeeeeieeelkesivkvlvevhssveelsekfleelkrki 243 
                  +w+ +WP +  l V++ + ++  e+ee++k + vk ++ ++s++++  +++ e ++ ++
  EFC37691.1 1381 QWILAWPGQVVLTVSQLFWTR--EVEESIKAQGVKGVQRYYSKMTKQQKSLIELVRGEN 1437
                  7*****************988..899999999999999999999998888877766555 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 5
       AAA_8  107 ntGevpnLfskeekeeiieelrkeakkqgvedskesllnffikrvr 152 
                   +G + +Lf + e +++  +  ++a  q  ++++ + + +fi+++ 
  EFC37691.1 1768 FNGIIKDLFPTTEHQKVDYSALENALIQTCAEMNLQPVPYFIQKII 1813
                  5899*********999987777777777899999999999999875 PP

  == domain 3  score: 334.6 bits;  conditional E-value: 4e-103
       AAA_8    1 ldLvlfedaiehlarilRvlrqprghaLlvGvgGsGrqsltkLAafiaelelfqievtkkykekefredlkkllkkag.ikqkevvfllsdnqiiee 96  
                  +dLvlf+ aieh++ri+R+++qp g+aLl+GvgGsGrqsltkLAaf ae++lf i++t++++++e+++++k+ll ++g  k++++vfl++dnqi+ +
  EFC37691.1 2531 MDLVLFNFAIEHIVRIVRIITQPGGNALLIGVGGSGRQSLTKLAAFAAEYKLFGIQLTRSFTVSEWKDKMKELLISVGgAKKTQTVFLFNDNQIKYQ 2627
                  9************************************************************************9999835556************** PP

       AAA_8   97 sfledinnlLntGevpnLfskeekeeiieelrkeakkqgvedskesllnffikrvrenLhivlcmspvgeafrsrlrkfpsLvncttidwfqeWPee 193 
                  +fledi+++LntGe+pnLf+++e+++i+e+lr++a+++++ +++e+l+nff++r++e Lhivlcmspvge++r++lr+fpsLvnc++idwf +WP++
  EFC37691.1 2628 EFLEDISSILNTGEIPNLFDRDEYKDICESLRAHARNENKGQTPEELYNFFVDRCKECLHIVLCMSPVGENLRNYLRMFPSLVNCCNIDWFSSWPDQ 2724
                  ************************************************************************************************* PP

       AAA_8  194 aLleVaekvlee.eeeieeelke...............sivkvlvevhssveelsekfleelkrkiyvtpksylellktykkl 260 
                  aL++Va+k++++ +e+++eel +               + v++++++h+s +els++fl ++kr++yvtp++yl llk++++l
  EFC37691.1 2725 ALHAVAQKFIKSiNEVTDEELDNnveipkddafekdfdKYVDICAYFHNSSTELSKQFLFKMKRHNYVTPTTYLGLLKNFSSL 2807
                  **********9964445555555777888999999999******************************************987 PP

>> AAA_9  ATP-binding dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  221.0   7.3   1.1e-68   9.6e-66       2     197 ..    3191    3395 ..    3190    3409 .. 0.94

  Alignments for each domain:
  == domain 1  score: 221.0 bits;  conditional E-value: 1.1e-68
                  HH.H.HT--STHHHHHHHHHHH...SSEEEEESSSTTHHHHHHH............HEESTTSTTHHHHHHHHHHTTSEEEESTT.SSHHSTTHHHH CS
       AAA_9    2 eW.nlqgLPsDelsieNaiivtks.erwPlliDPqgqankwiknkekek......lkviklsdkkflktLenairfGkplliedvgeeldpiLepvL 90  
                  +W   +gLPsD++s+eNa+iv+++ + wPl+iDPqgqa++wik+kek++      l +i++s+++++k+Le+ai+ G++ ++e vgeeldp+Lep+L
  EFC37691.1 3191 NWiIKEGLPSDDFSVENATIVKRTtNIWPLFIDPQGQAMAWIKEKEKQQkkdadsLLIIQMSNPSLIKSLEKAITQGTTTIVEGVGEELDPALEPLL 3287
                  798789****************86699****************99666657777777**************************************** PP

                  TTCCEE...CEEEESSSE.EE--SSCEEEEEESSTTSHHHHHHHHHSEEEE---SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       AAA_9   91 ekeiikkg.rkliklgdkeieysenFrLylttklsnphyspeiaakvtlinFtvteeGLedqlLaevvkkerpeleekkeeliqeeaenkkqlkele 186 
                  +++++  g  k+i+l d+   y++nF+Lyl+t lsnphy pe+++kv++inF++t++GLe+qlLa+vvk e+++le++k++l  ++a++++qlk+ +
  EFC37691.1 3288 TQRTYYIGgVKYINLSDTPTIYNDNFKLYLVTSLSNPHYLPEVSTKVQIINFMITPNGLEEQLLAIVVKIEEKKLESEKNNLAVQNAKYQEQLKHYQ 3384
                  ****99644**************************************************************************************** PP

                  HHHHHHHHHSS CS
       AAA_9  187 dklLeeLseae 197 
                  dk+L+ L++++
  EFC37691.1 3385 DKILQLLQTSR 3395
                  *******9986 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.074        67      40      63 ..    1548    1570 ..    1521    1588 .. 0.84
   2 !  213.7   0.0   1.6e-66   1.4e-63       3     180 ..    2147    2339 ..    2145    2340 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.074
       AAA_7   40 GptGtGKtviikdllkkldkekyl 63  
                  Gp+GtGKt ++kdl k++ k +++
  EFC37691.1 1548 GPAGTGKTETTKDLAKAIAK-HCV 1570
                  9*************999984.333 PP

  == domain 2  score: 213.7 bits;  conditional E-value: 1.6e-66
       AAA_7    3 ideeakfseilVptvdtvrysyllelllknkkpvllvGptGtGKtviikdll.............kkldkekylsltinfsaqtsanqlqdiieskl 86  
                  ++++ +f++i+Vpt+dt+r++++l++ll+++k+ l+vGptGtGK+ ++k++l             ++ +k+++l+++infsa+t+++ +qdi+eskl
  EFC37691.1 2147 VSPTEEFRNIIVPTMDTIRFQFILKTLLDHGKQPLFVGPTGTGKSEYVKQFLlklgagsseekeqNNEPKSNFLPAFINFSATTTPSLIQDILESKL 2243
                  678999********************************************6623333333332223446789************************* PP

       AAA_7   87 ekrrkgvygPpggkklvvFvDDlnmpakekygaqppiellRqlldyggwYdr..kklefkeikdvqlvaamgppgggrneitpRllrhfnvlaite 180 
                   +r++g  gPp gkk ++FvDDln+p+ ++ygaqp+iellR + d+ggw+++  k+  f++++dv +v+amgppgggrne+tpR++rhfnv+ +t+
  EFC37691.1 2244 TRRKQGYIGPPIGKKTIIFVDDLNLPTLDDYGAQPTIELLREWQDRGGWHEKfsKQAAFTHVVDVLFVCAMGPPGGGRNEVTPRFIRHFNVIGLTS 2339
                  ****************************************************97778***********************************9886 PP

>> AAA_lid_11  Dynein heavy chain AAA lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       3.8   3.4e+03      69     118 ..    1479    1532 ..    1474    1565 .. 0.78
   2 !  203.9   0.0   1.4e-63   1.3e-60       1     164 []    3767    3934 ..    3767    3934 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.8
                  HHHHHHHHCSS....GGS-HHHHHHHHHHTTTSTT--SHHHHHHHHHHHHHHSS CS
  AAA_lid_11   69 vlkmyldeyee....kevpwealkyligeinYGGrvtDdwDrrllktyleeffs 118 
                  +l+ y +++++    k+ +   ++ +++einYG +   +  r +++ +++++++
  EFC37691.1 1479 QLRYYWEDVKDikdgKNQNQIVVRQVTAEINYGYEYLGNQERLVITPLTDRCYR 1532
                  55566555555555555566678999*******988888888888877777765 PP

  == domain 2  score: 203.9 bits;  conditional E-value: 1.4e-63
                  HHHHHHHHCT-HHHHT............HHHHHHHHHHHHHHHHHGGGGTTTS-SS-----HHHHHHHHHHHHHHHHHCSSGGS-HHHHHHHHHHTT CS
  AAA_lid_11    1 kanllraysnesekideeffee..keeefkkllfsLcffHavvqeRrkFgplGwnipYeFnesdleisvevlkmyldeyeekevpwealkyligein 95  
                  +anll++++++++  d ++f+   k++efkkllf+L+ffH++vqeRr+FgplGwni YeFn+sdl+is+++l+m+l+  + ++vp++al+yl+ge+n
  EFC37691.1 3767 RANLLQSWNSDPI-NDAKYFTGckKSREFKKLLFGLTFFHSLVQERRTFGPLGWNIRYEFNDSDLNISLKQLQMFLNGKD-SNVPFKALTYLTGECN 3861
                  89******99886.55578875679999************************************************9887.9*************** PP

                  TSTT--SHHHHHHHHHHHHHHSSGGGGSTT.....-T...E---.SSHHHHHHHHCTS-SS--CCCCTS-TTH CS
  AAA_lid_11   96 YGGrvtDdwDrrllktyleeffseevleeeyk...sgeykipee.ksleeyleyieslpladspevfglhena 164 
                  YGGrvtDd Drr+l+++l++f++ee++e+ y+   sg y++p+  k+++ey+++ie++p +++pevfglhena
  EFC37691.1 3862 YGGRVTDDHDRRTLMAILSDFYNEEIIEDGYQlspSGIYTVPNGdKKHSEYIQTIEKFPSSETPEVFGLHENA 3934
                  ***************************999998655899999876889************************8 PP

>> Dynein_heavy  Dynein heavy chain region D6 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0      0.22     2e+02      10      98 ..    3222    3323 ..    3217    3338 .. 0.70
   2 !  140.9   0.0   2.1e-44   1.9e-41       2     119 .]    3646    3766 ..    3645    3766 .. 0.96

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.22
                    E-TT--THHHHHHHHHHTT--EEEEETTSHHHHHHHHHHHHHHHHT-EEEEE-GGG-CCCHHHHHHH......................HHTT-E CS
  Dynein_heavy   10 lspgadptesleklakklkklvksvslGqgqeeeaekalekaakegsWvlLqNchlapswlkeLekileel...............eeklhssfR 89  
                    + p+ ++++++++  k++kk   s+ + q +++   k leka+++g+  +++ +       + Le +l +                 +  +++f+
    EFC37691.1 3222 IDPQGQAMAWIKEKEKQQKKDADSLLIIQMSNPSLIKSLEKAITQGTTTIVEGVGEE--LDPALEPLLTQRtyyiggvkyinlsdtPTIYNDNFK 3314
                    5667789999999999999999************************99999987544..334555553322334444444455544555566888 PP

                    EEEEEES-T CS
  Dynein_heavy   90 lwltsepsp 98  
                    l+l +  s+
    EFC37691.1 3315 LYLVTSLSN 3323
                    888555444 PP

  == domain 2  score: 140.9 bits;  conditional E-value: 2.1e-44
                    TTS-EEEEE-TT--THHHHHHHHHHTT--EEEEETTSHHHHHHHHHHHHHHHHT-EEEEE-GGG-CCCHHHHHHH..........HHTT-EEEEE CS
  Dynein_heavy    2 pttPvlfilspgadptesleklakklkklvksvslGqgqeeeaekalekaakegsWvlLqNchlapswlkeLekileel...eeklhssfRlwlt 93  
                    p  P++filspg+dp+e+l k+a++ +  +ks+slGqgqee a +++++++ +g+Wv+LqNch+++s+l++Leki++++   e+kl  ++Rlwlt
    EFC37691.1 3646 PVKPLIFILSPGVDPMENLRKFADQEGVALKSLSLGQGQEEFAIEMINQGSFQGNWVVLQNCHVLLSFLPKLEKIIDDFarnENKLAANYRLWLT 3740
                    568************************99***********************************************988777777888******* PP

                    EES-TTS-HHHHHTSEEEEE---SSH CS
  Dynein_heavy   94 sepspkfPislLqssikvtnepPkgl 119 
                    s+ps+kfP+s+Lq+++k+tnepPkgl
    EFC37691.1 3741 SMPSEKFPVSVLQRGVKITNEPPKGL 3766
                    ************************97 PP

>> MT  Microtubule-binding stalk of dynein motor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.1  14.6   5.4e-41   4.8e-38       3     338 ..    2822    3161 ..    2820    3166 .. 0.86

  Alignments for each domain:
  == domain 1  score: 131.1 bits;  conditional E-value: 5.4e-41
          MT    3 lengllklqstaaqvddlkaklaaqe...velkqknedadkliqvvgvetekvskekaiadeeekkvavinkevkkkqkdceedlakaepallaaqe 96  
                  +e gl ++  t ++v++++  l + +   +el ++ne+  k i++   +++  +k+    ++ee   +v ++e  + +  c e+la+aep  + aq+
  EFC37691.1 2822 FELGLQRIAETDKDVNEMQKELEILQpnlIELSKQNEELSKKIEIESQNANEKAKKIE-IEQEEINAQVAKNE--QDKVYCMEELAQAEPIWIEAQQ 2915
                  6889***************999875523378888888888877776666665444333.35666666655544..44567***************** PP

          MT   97 alntlnktnltelksfgsppdavvnvaaavmvllaprgkv......pkdrs.wkaakivmakvdafldslinfdkenihenclkaikeylndpefep 186 
                   ++ +  ++++e++ + +pp+ v  v  a+ ++   + k        k +  w a+k +m++ d fl  ++nfd   ++++   ++ + l   e++ 
  EFC37691.1 2916 KVKDISTAQIAEVRGMQAPPEGVKMVLKAICIMKGEKVKTiddglgNKSKDwWGASKEMMSRKD-FLKYIKNFDMGALNQEIVGTLTPILA--EMDV 3009
                  *****************************99998776665111111566663567788888766.************************97..6788 PP

          MT  187 efikskslaaaglcswvinivrfyevycdvepkrqalekanaelaaaqeklaaikakiaelnanlaeltaafekatadklkcqqeaeatartislan 283 
                  e ik  s aa  l  w+  +v+++ v   vepkr al++a+++ a+a   la  k  +ae++  +a   ++ + + a+k + + e +  ++ +  a 
  EFC37691.1 3010 EKIKRSSAAAFALNEWLNALVKYFRVNSVVEPKRLALQEAEQKCAEAARYLAEKKRELAEIQGMIALKETERKECEAKKNQLEHEYQLVSVKLERAT 3106
                  99*************************************************************99988888888889999999999999999999** PP

          MT  284 rlvgglasenvrwaeavenfksqektlcgdvllitafvsyvgfftkkyrqelldr 338 
                  +l+g l  e++rw e+++++ +q+  + gdv+l + ++sy+g ft +yr+++l++
  EFC37691.1 3107 KLIGLLEGEKLRWQETLAKIMEQQTCINGDVILASGIISYLGAFTSEYRRKILKK 3161
                  **************************************************99976 PP

>> Dynein_AAA_lid  Dynein heavy chain AAA lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.5   1.1   1.1e-24   9.4e-22       2     128 ..    2004    2137 ..    2003    2138 .. 0.90

  Alignments for each domain:
  == domain 1  score: 77.5 bits;  conditional E-value: 1.1e-24
  Dynein_AAA_lid    2 eelfeklvepclefvrkkc..keivpv.tdlnlvqslcrllealldefeekeeesadeeleeeeleevleklflfalvWSiGatldedsrekf 91  
                      ++lf ++++p+++  ++++  k +v v +d  lv+sl+++l++l+def++ +      +   ++++ +le+lf fal+WS+G  + + +r kf
      EFC37691.1 2004 KTLFSTFIPPAIKIFKSHFmaKAYVRVkSDAMLVNSLINILQSLMDEFADPKVI----QNYIKDKSIILECLFQFALIWSVG--IVSVDRVKF 2090
                      789************999877889988689*****************9999865....566777899***************..7889***** PP

  Dynein_AAA_lid   92 deflrellee.........alklp.peegtvyDyffdketgkWkpWe 128 
                      d+  r++lee         ++++p + + +v+D++fdk+++kW++W+
      EFC37691.1 2091 DQLYRNMLEErarnkvykfQIPMPeKPNTLVFDFVFDKKSRKWVEWT 2137
                      *********99**99997666666888999****************8 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.0     8e-10   7.2e-07       6     138 .]    1548    1668 ..    1547    1668 .. 0.94
   2 !    8.2   0.0    0.0025       2.3       2     137 ..    1825    1959 ..    1824    1960 .. 0.80
   3 !   16.0   0.0     1e-05     0.009       3     138 .]    2181    2332 ..    2180    2332 .. 0.78
   4 !    9.6   0.0   0.00095      0.85       2      45 ..    2557    2600 ..    2556    2634 .. 0.91
   5 ?   -2.0   0.1       3.7   3.3e+03      64     101 ..    2890    2930 ..    2856    2953 .. 0.71

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 8e-10
                  --SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--.........--------G-SEEEEESGGG--HHHHHHHHHHHHSSEEE..-SSSE CS
       AAA_5    6 GppGtgKselaerlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraaregeilvlDEveraesevlnsLlslleerrllleeggel 102 
                  Gp GtgK+e ++ la+a+ +  +++++++d+t+e + +  +                a +g+  ++DE++r+e +vl+++ + + + +l ++++ ++
  EFC37691.1 1548 GPAGTGKTETTKDLAKAIAKHCVVYNCSDDLTYESMAQFFRG--------------LASSGAWSCFDEFNRIELDVLSVVAQQIQTIQLAVASRATR 1630
                  9*************************************9992..............4579************************************* PP

                  EE---........-EEEEEESS--.-TT-TTHHHHTT- CS
       AAA_5  103 vkakndd.ller.frviatanpldrslnelspalrsRf 138 
                    ++n +  +++   ++ t+np + +++el  +l+ +f
  EFC37691.1 1631 FFFENMEiNMNPtCAIFITMNPGYAGRSELPDNLKALF 1668
                  *****9987777899**************999999877 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0025
                  EEEE--SSSSHHHHHHHGGGGB...S--EEEEE--TT--H.HHHH--B--.........--------.........G-SEEEEESGGG--HHHHHHH CS
       AAA_5    2 vlLvGppGtgKselaerlaaal...nreveyvqltrdtte.edlkgrreikngttslvdsplvraar.........egeilvlDEveraesevlnsL 85  
                  ++LvG p +gK+     l++al   + +++   l+ +  +  +l g r+   +t+ ++d++l   ++         ++++++++ v+     +++s+
  EFC37691.1 1825 LMLVGFPMSGKTASYIVLKSALeklGEKINLRVLSPKAVYgGNLYGYRD--TKTKDWKDGVLALHFQklstlaekeRKWLMCDGPVD---AIWIESM 1916
                  7899999999998888888888555555555544444333145555555..69999*******9999********99**********...99***** PP

                  HHHHHSSEEE..-SSSEEE---......-EEEEEESS--.-TT-TTHHHHTT CS
       AAA_5   86 lslleerrllleeggelvkaknddllerfrviatanpldrslnelspalrsR 137 
                  +++l++++ l   +g+ +k  ++     ++ +++  +l      +spa++sR
  EFC37691.1 1917 NTVLDDNKKLCLTSGQIIKMGEN-----MNMMFEVQDLA----AASPATVSR 1959
                  ******************99998.....88888888877....778888887 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 1e-05
                  EEE--SSSSHHHHHHHGGGGB................S--EEEEE--TT--HHHHH--B--.........--------G-SEEEEESGGG--HHHHH CS
       AAA_5    3 lLvGppGtgKselaerlaaal................nreveyvqltrdtteedlkgrreikngttslvdsplvraaregeilvlDEveraesevln 83  
                  l vGp+GtgKse +++++  l                n     +++++ tt++ ++  +e  ++ t+++++ +   + ++ i+++D+++    +  +
  EFC37691.1 2181 LFVGPTGTGKSEYVKQFLLKLgagsseekeqnnepksNFLPAFINFSATTTPSLIQDILE--SKLTRRKQGYIGPPIGKKTIIFVDDLNLPTLDDYG 2275
                  689******************977777776665554334444566666666666666666..5666666666666666***********99999999 PP

                  HHHHHHHSSEEE..-SSSEEE---.........-EEEEEESS--.-TT-TTHHHHTT- CS
       AAA_5   84 sLlslleerrllleeggelvkakndd.ller..frviatanpldrslnelspalrsRf 138 
                  +  + +e  r + + gg+ +k++++  ++    + ++ ++ p+ +++ne++p++++ f
  EFC37691.1 2276 AQ-PTIELLREWQDRGGWHEKFSKQAaFTHVvdVLFVCAMGPPGGGRNEVTPRFIRHF 2332
                  99.5555555555**********998888879999999999999*********99976 PP

  == domain 4  score: 9.6 bits;  conditional E-value: 0.00095
                  EEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B CS
       AAA_5    2 vlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrr 45  
                   lL+G  G+g+ +l++  a a + +++ +qltr+ t ++ k ++
  EFC37691.1 2557 ALLIGVGGSGRQSLTKLAAFAAEYKLFGIQLTRSFTVSEWKDKM 2600
                  59*********************************999877665 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 3.7
                  -...G-SEEEEESGGG--HHHHHHHHHHHHSSEEE..-SSS CS
       AAA_5   64 r...egeilvlDEveraesevlnsLlslleerrllleegge 101 
                      + ++++++E+ +ae+ ++++ +++ +  + +++e ++
  EFC37691.1 2890 AkneQDKVYCMEELAQAEPIWIEAQQKVKDISTAQIAEVRG 2930
                  2555789***************9998887777777666655 PP

>> AAA_lid_1  AAA+ lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.8   0.0   2.3e-18   2.1e-15       4      81 ..    2376    2456 ..    2373    2470 .. 0.88

  Alignments for each domain:
  == domain 1  score: 56.8 bits;  conditional E-value: 2.3e-18
   AAA_lid_1    4 aalalhkkiaatflptaikfhyvfnlrdlsnifqgllfssaevlkapld...lirlylheservygdkmveekdlellekv 81  
                   +++l + + + f pt  k hy fnlrdls ifqg+   ++ +  + l+   l++++ he+ rv+ d++++e+d e++ ++
  EFC37691.1 2376 GSINLFNNVIEQFRPTPEKSHYTFNLRDLSKIFQGVCSVGPRLDGSELEkvsLVKIWAHEATRVFHDRLINEQDRESFYQL 2456
                  5789999******************************99999887765333399**********************99876 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0    0.0002      0.18       5      64 ..    1548    1608 ..    1547    1628 .. 0.77
   2 !    7.3   0.0    0.0068       6.1       3      32 ..    2182    2211 ..    2181    2225 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.0002
  RNA_helicase    5 GpsgeGKStlakeLakallkklklkkkdsvysrnpeddfwdgYt.gqevvvidDfgqvkde 64  
                    Gp+g+GK+ ++k+Laka++k+    + ++  + ++  +f+ g   + +  ++d+f++++ +
    EFC37691.1 1548 GPAGTGKTETTKDLAKAIAKHCVVYNCSDDLTYESMAQFFRGLAsSGAWSCFDEFNRIELD 1608
                    9********************9666656666678999999999967777888888888755 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0068
  RNA_helicase    3 lyGpsgeGKStlakeLakallkklklkkkd 32  
                    ++Gp+g+GKS ++k++  +l   + ++k++
    EFC37691.1 2182 FVGPTGTGKSEYVKQFLLKLGAGSSEEKEQ 2211
                    79*************999998666444433 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       5.6     5e+03      31      62 ..     765     794 ..     734     831 .. 0.69
   2 !    9.5   0.0    0.0014       1.3       5      46 ..    1548    1583 ..    1547    1648 .. 0.79
   3 !    7.5   0.0    0.0058       5.2       2      68 ..    2181    2267 ..    2180    2290 .. 0.66
   4 ?    0.5   0.1      0.82   7.3e+02       2      63 ..    2558    2618 ..    2557    2624 .. 0.73

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 5.6
                 TTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEE CS
         AAA  31 gsellskyvgesekkirelfkeakekakpsil 62 
                 +++l+sk+  e ++ki + f+++ +k    i+
  EFC37691.1 765 LMKLISKWSTEESSKITQSFRDVYSKV--QII 794
                 456667799999999999999876654..444 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.0014
                  SSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHH CS
         AAA    5 GppGtGKTllakavakelgvefleisgsellskyvgesekki 46  
                  Gp GtGKT + k +ak +  +++  ++s+ l      + +++
  EFC37691.1 1548 GPAGTGKTETTKDLAKAIAKHCVVYNCSDDL------TYESM 1583
                  9******************999999999988......33333 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0058
                  EEESSTTSSHHHHHHHHHHHHTHE..................EEEEETTTCSSSSTTHHHHHHHHHHHHH..HHTS........TSEEEEEETGG CS
         AAA    2 llyGppGtGKTllakavakelgve..................fleisgsellskyvgesekkirelfkea..keka........kpsilfiDEid 68  
                  l++Gp GtGK+  +k+   +lg+                   f+++            +++ i++++++   ++k+        k++i+f+D++ 
  EFC37691.1 2181 LFVGPTGTGKSEYVKQFLLKLGAGsseekeqnnepksnflpaFINF--------SATTTPSLIQDILESKltRRKQgyigppigKKTIIFVDDLN 2267
                  89******************95332223333344333333222222........44446677777777632233336788888777999999975 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.82
                  EEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTS.TSEEEE CS
         AAA    2 llyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakeka.kpsilf 63  
                  ll+G  G G+ +l k  a  ++ +++ i++++ +  +v+e ++k++el+ ++   + ++++++
  EFC37691.1 2558 LLIGVGGSGRQSLTKLAAFAAEYKLFGIQLTRSF--TVSEWKDKMKELLISVGGAKkTQTVFL 2618
                  89***********************999999998..666666666666655422222224444 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0     0.017        15      12      56 ..    1548    1583 ..    1547    1609 .. 0.81
   2 ?   -2.9   0.0       8.4   7.5e+03       8      29 ..    1825    1846 ..    1824    1860 .. 0.82
   3 !   12.5   0.0   0.00015      0.14       9      68 ..    2181    2247 ..    2175    2285 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.017
      AAA_22   12 GesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdl 56  
                  G++GtGKT + + l++            +++v ++++ + + +++
  EFC37691.1 1548 GPAGTGKTETTKDLAKAI---------AKHCVVYNCSDDLTYESM 1583
                  9****************9.........889999999887744443 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 8.4
      AAA_22    8 lvvtGesGtGKTtllrrlleql 29  
                  l+++G + +GKT ++  l++ l
  EFC37691.1 1825 LMLVGFPMSGKTASYIVLKSAL 1846
                  6899********9986666655 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 0.00015
      AAA_22    9 vvtGesGtGKTtllrrlleqldeeakaee.....erpevv..fvtlpsstsskdllrellralglel 68  
                  + +G++GtGK+  ++++l +l + ++ e+     +++ ++  f++ ++ t+++ +   l ++l++++
  EFC37691.1 2181 LFVGPTGTGKSEYVKQFLLKLGAGSSEEKeqnnePKSNFLpaFINFSATTTPSLIQDILESKLTRRK 2247
                  569******************9888888799997666666989999999998888666666666655 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0    0.0034         3      31      76 ..    1548    1599 ..    1546    1668 .. 0.69
   2 ?    6.4   0.0     0.012        11      16      88 ..    2170    2241 ..    2163    2284 .. 0.71
   3 ?   -0.9   0.0       2.1   1.9e+03      20      51 ..    2551    2581 ..    2539    2671 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0034
      AAA_16   31 GesGvGKsslvrellralekdggiflrgkcdqlesaipy............salaqal 76  
                  G++G+GK+   + l++a+ k+   +++   d+l    +y            s  ++++
  EFC37691.1 1548 GPAGTGKTETTKDLAKAIAKH--CVVYNCSDDL----TYesmaqffrglasSGAWSCF 1599
                  9******************99..2333333333....332211113333324455555 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.012
      AAA_16   16 lervrsgrpelvllsGesGvGKsslvrellralekdggiflrgkcdql..esa.ipysa.laqalareellrqllde 88  
                  l+++ +++    l++G+ G+GKs  v+++l  l +      ++k + +  +s+ +p  + +  + +  +l++++l+ 
  EFC37691.1 2170 LKTLLDHGK-QPLFVGPTGTGKSEYVKQFLLKLGAG---SSEEKEQNNepKSNfLPAFInFSATTTP-SLIQDILES 2241
                  555555553.34689************999766665...3444444445433354444425555544.777777655 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 2.1
      AAA_16   20 rsgrpelvllsGesGvGKsslvrellralekd 51  
                   +++ ++ ll+G  G+G  sl + ++ a+e +
  EFC37691.1 2551 TQPG-GNALLIGVGGSGRQSLTKLAAFAAEYK 2581
                  3333.8999********999998777666655 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.1   0.00056      0.51      55     127 ..     296     369 ..     290     395 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00056
  Methyltransf_31  55 nveFeqgdieelekl.ledekfDlilsnevlnaladpdkileeiervlkpggilliedprllaelpakveeesk 127
                      +++F q    ++e++ +   ++D  +++++++ +++ ++i+e+i +++ +++ +l++++ + +++ ++++e+ k
       EFC37691.1 296 RIRFAQMRRKKFEEKmFYYLQIDKTITDDLIDITPFEKQIYEKILKLVANESQFLSRHVPVIEKYVDEAKEHYK 369
                      67788877778555556669***************************************988888877777665 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.1    0.0032       2.9      24      45 ..    1547    1568 ..    1540    1595 .. 0.88
   2 ?   -1.2   0.0       1.6   1.4e+03      22      56 ..    1826    1862 ..    1820    1877 .. 0.80
   3 ?    0.1   0.0      0.64   5.7e+02      20      37 ..    2179    2196 ..    2168    2200 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0032
      AAA_30   24 tGpAGtGKttalkalreaweaa 45  
                  +GpAGtGKt + k l++a++++
  EFC37691.1 1547 EGPAGTGKTETTKDLAKAIAKH 1568
                  7**************9999875 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.6
      AAA_30   22 vltGpAGtGKttalkalreaweaag..grviglAptg 56  
                  +l+G + +GKt +  +l+ a+e+ g   ++ +l+p++
  EFC37691.1 1826 MLVGFPMSGKTASYIVLKSALEKLGekINLRVLSPKA 1862
                  6889999*****************9334445666655 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.64
      AAA_30   20 vavltGpAGtGKttalka 37  
                    + +Gp GtGK+  +k+
  EFC37691.1 2179 QPLFVGPTGTGKSEYVKQ 2196
                  56789********98875 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.41   3.7e+02       6      26 ..    1548    1570 ..    1546    1631 .. 0.83
   2 ?   -0.8   0.0       1.8   1.6e+03       2      39 ..    1825    1870 ..    1825    1903 .. 0.57
   3 ?    5.6   0.2     0.019        17       3      24 ..    2181    2202 ..    2181    2206 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.41
      AAA_33    6 GlpGsGKstlaerllkklg..av 26  
                  G++G+GK+   + l+k+ +  +v
  EFC37691.1 1548 GPAGTGKTETTKDLAKAIAkhCV 1570
                  9************9988666444 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.8
      AAA_33    2 vllvGlpGsGKstlaerl...lkklg....avllssdtlrr.rlfg 39  
                  ++lvG p sGK+  +  l   l+klg      +ls  +++  +l+g
  EFC37691.1 1825 LMLVGFPMSGKTASYIVLksaLEKLGekinLRVLSPKAVYGgNLYG 1870
                  589*********8665553336666666644444444444445555 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.019
      AAA_33    3 llvGlpGsGKstlaerllkklg 24  
                  l+vG+ G+GKs ++++ l klg
  EFC37691.1 2181 LFVGPTGTGKSEYVKQFLLKLG 2202
                  69**************988877 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       5.2   4.7e+03       9      25 ..     704     731 ..     703     780 .. 0.62
   2 ?   10.7   0.0   0.00066      0.59       5      67 ..    1548    1620 ..    1547    1653 .. 0.70
   3 ?   -1.3   0.0       3.3     3e+03       3      16 ..    2182    2195 ..    2181    2216 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 5.2
      AAA_18   9 vGKttlakeL...skrlgf........g 25 
                 vGKt+++k L   +++l+          
  EFC37691.1 704 VGKTEMSKLLsifREELARlksdseevY 731
                 8*********777444422244444432 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00066
      AAA_18    5 GtpGvGKttlakeLskrl.gf..gvnlrdvakenglllevdpe.......aldeskrldedkldklldaleen 67  
                  G++G+GKt+ +k L+k   +   ++n++d ++ + +   +           +de++r++ d+l ++ ++++ +
  EFC37691.1 1548 GPAGTGKTETTKDLAKAIaKHcvVYNCSDDLTYESMAQFFRGLassgawsCFDEFNRIELDVLSVVAQQIQTI 1620
                  9*************99863326877777777766555544444777777788888888888888887777766 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 3.3
      AAA_18    3 ltGtpGvGKttlak 16  
                    G+ G+GK++  k
  EFC37691.1 2182 FVGPTGTGKSEYVK 2195
                  57********9766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (4270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2137  (0.119192); expected 358.6 (0.02)
Passed bias filter:                      672  (0.0374812); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                        44  (0.00245412); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 2.03u 0.36s 00:00:02.38 Elapsed: 00:00:00.62
# Mc/sec: 20880.74
//
Query:       EFC37692.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.14   12.2   0.0        0.3   11.1   0.0    1.6  1  AAA_14    AAA domain


Domain annotation for each model (and alignments):
>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   1.7e-05       0.3       6      42 ..      47      86 ..      43     145 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 1.7e-05
      AAA_14  6 vitGaRrvGKTtllkqlikell...vkkesilyinldder 42
                 + G+R +G Ttl++q++   l    + +s++ i l +++
  EFC37692.1 47 SLLGVRGSGRTTLMFQYAMGVLkndPDTSSTVMILLHRNS 86
                689**************98777655444555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       747  (0.0416643); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.35s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1802.13
//
Query:       EFC37693.1  [L=1146]
Description: hypothetical protein NAEGRDRAFT_81846 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-33  115.9   0.0    4.3e-33  114.2   0.0    2.0  1  NFACT-R_1   NFACT protein RNA binding domain
    6.4e-32  110.9  24.5    3.6e-26   92.0   0.2    3.6  3  FbpA        Fibronectin-binding protein A N-terminus (FbpA)
    7.7e-20   70.8   0.0    7.7e-20   70.8   0.0    5.7  7  NFACT-C     NFACT protein C-terminal domain
  ------ inclusion threshold ------
        0.9    9.7   8.9        0.4   10.8   0.6    3.6  2  ASL_C       Adenylosuccinate lyase C-terminal


Domain annotation for each model (and alignments):
>> NFACT-R_1  NFACT protein RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  114.2   0.0   9.7e-37   4.3e-33       1     109 []     636     746 ..     636     746 .. 0.99

  Alignments for each domain:
  == domain 1  score: 114.2 bits;  conditional E-value: 9.7e-37
   NFACT-R_1   1 kvfwFkssdgylvimGkDkqeneelikkyleesdvwfhvdkessahvylrlsegeleeipeelleeaaqlakanSia.gnklssvdvvyvpasnlskta 98 
                 k++wF++s++ylv++G+D+q+ne ++k+y++++d+++h+d++++++++++++ ge  +ip+ +l+ea+ +++++S a +nk+   ++++v+ +++skta
  EFC37693.1 636 KFYWFITSENYLVLGGRDAQQNELVVKRYMRKGDIYIHADVHGASSCIIKNPTGE--PIPPLSLQEAGMFCVCRSVAwDNKV-MSSAYWVYDHQVSKTA 731
                 8******************************************************..*************************.**************** PP

   NFACT-R_1  99 p....ldtGsvgfkg 109
                 p    l++Gs++++g
  EFC37693.1 732 PtgeyLTVGSFMIRG 746
                 ************986 PP

>> FbpA  Fibronectin-binding protein A N-terminus (FbpA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.0   0.2   7.9e-30   3.6e-26       2     145 ..       7     141 ..       6     157 .. 0.95
   2 !   31.4  19.0   1.8e-11   8.2e-08     237     409 ..     364     611 ..     339     630 .. 0.79
   3 ?  -14.0  20.7         4   1.8e+04     171     319 ..     870    1012 ..     839    1019 .. 0.73

  Alignments for each domain:
  == domain 1  score: 92.0 bits;  conditional E-value: 7.9e-30
                 HHHHHHHHHHHHHHHTTXEEEEEEEEETTEEEEEEEETTEEEEEEEEXXTTTXEEEEXXXXXXXXSSXXHHHHHHHHHHTTXEEEEEEEXTTSSEEEEE CS
        FbpA   2 glvlaavvaELqkellggridkiyqpekdelvltlranrgrhkLllsahpsyarihltekpkenpkeppnFcmlLRkyLkgarivsieqlgfdRivels 100
                  ++++++vaEL+++l+g r+ + y  +k++  l++ + +++  +l++    + rih t  ++++ k+p+ F+  +Rk+++  r++++eqlg+dR+v+++
  EFC37693.1   7 VVDIRCIVAELREQLIGMRLANLYDINKKTYLLKFAKTDEKIVVLIES---GIRIHSTAFERDKSKMPSPFVLKMRKHIRTRRLEKLEQLGVDRVVDFT 102
                 589*********************************989998899**9...************************************************ PP

                 EEEEXTTSXEEEEEEEEEXXGGGXEEEEEETTTEEEEESSXBXXX CS
        FbpA 101 iekrdElgdeeeytLivEimgrhSNiiLvdeenkIidaikhvspk 145
                 +        e+ y+LivE +++ +N++L+d + kIi  ++  s++
  EFC37693.1 103 FGAE-----EKAYHLIVEFFAK-GNVVLTDYQYKIISILRTHSKE 141
                 ****.....*************.**************99988765 PP

  == domain 2  score: 31.4 bits;  conditional E-value: 1.8e-11
                 HHHTXXX....XXEE.....XSSSEESSXXTTXX.SSXXXXSXHHHHHHHHTTTXXX--SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCGGH... CS
        FbpA 237 elleeleeekfepqlvlkeekpeefsvvplkslselekesfdslsealdeyYakkaerdrveqkrsdlekrveneleklekklkklekelekaeka... 332
                   +++ + ++f+p+l+     ++  + +p   +++ +  +fds+ +  de++++  e++++e+++s++e++ve+++ k +++++   +el+++ ++   
  EFC37693.1 364 LSIKRDQYDDFTPFLF-----EQVRRKIPA-DKNQIKVIEFDSFDRSADEFFSA-IEAKKIESQKSSIENTVEKKMSKVKREQELKLQELQASFDKyet 455
                 4444444445555553.....112222232.33567889*************87.56778899999999999999888888777777777777777777 PP

                 ......HHHHCCHH-----------------------.--........................................................... CS
        FbpA 333 ......enyrligelltaylyaikkgmsevelenyydege........................................................... 366
                        +y+++++ + ++ +a+++ +s+ +++++++e +                                                           
  EFC37693.1 456 iatlieTHYEIVDQAIQVICSALAQSQSWETIKQIIKEHRdvdpiaamihklklessqitvtlpppsiddddedefeyeesdeenddedeesddeekke 554
                 7************************************84479********************************************************* PP

                 ..........---------------HHHHHHHHHHHHHHHHHH....HHHHHHHHHH CS
        FbpA 367 ..........evtIpLdprkspsenAqkyfkkykKlkraveav....eeqieetkee 409
                           +++I +d++++++ nA ky+   kK  + +e++    +++i++t+++
  EFC37693.1 555 kksdkkkkeePMRIDIDISLTAHANAAKYYSLRKKSGENKEKAafasKKAIKKTEQK 611
                 *********************************998655554412225556655554 PP

  == domain 3  score: -14.0 bits;  conditional E-value: 4
                  SXXH.HHHHHHHHHS.XXXHHHHHHHBTTXXHHHHHHHHTTXSSSH...............HHHHHHHHTXXX....XXEE.....XSSSEESSXXT CS
        FbpA  171 eaeeleefkellskkekdlvkaLvkafqGlspllaeelleragldketsakelseedlerlyealqelleeleeekfepqlvlkeekpeefsvvplk 267 
                  e +e ++ k +ls kek++ + L k+  G+ ++ a+el+ + +  +    ++ ++ed+++  e+ ++  +  + ++  p++  k  k+ + + ++ k
  EFC37693.1  870 EKTEGNDKKRALSAKEKKILQRLKKK--GMTEQAARELIISGQATE---DSKSQKEDAKKQDEETEDSENTENDKSTLPTHKPKGMKRGKWKKLKTK 961 
                  44443455666777899999999999..***********8877444...467788999999999999988888888888985555577777777676 PP

                  TXX.SSXXXXSXHHHHHHHHTTTXXX--SHHHHHHHHHHHHHHHHHHHHHHH CS
        FbpA  268 slselekesfdslsealdeyYakkaerdrveqkrsdlekrveneleklekkl 319 
                  +  ++++e+ + + e++ +  +++ ++d+++q +++ e++ +++ + + +  
  EFC37693.1  962 Y-ADQDEEERQVMIELIGNKPKERPKEDEMKQVQKKKEEEQRKKKQEQAEIK 1012
                  6.46778999999999999999999999999999888888777666655443 PP

>> NFACT-C  NFACT protein C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.3      0.21   9.2e+02      74     104 ..     479     508 ..     413     510 .. 0.80
   2 ?   -5.1   2.5         4   1.8e+04      67      76 ..     547     556 ..     531     568 .. 0.44
   3 ?   -2.2   0.5      0.88     4e+03      67      98 ..     594     625 ..     576     630 .. 0.58
   4 ?   -1.3   1.3      0.44     2e+03      65      94 ..     867     897 ..     821     908 .. 0.67
   5 ?   -1.8   2.5      0.63   2.8e+03      48      77 ..     893     929 ..     880     950 .. 0.60
   6 ?   -5.9   7.4         4   1.8e+04      49      91 ..     951    1016 ..     944    1024 .. 0.55
   7 !   70.8   0.0   1.7e-23   7.7e-20       2     105 ..    1028    1121 ..    1027    1122 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.21
     NFACT-C  74 dkeklwprekelikalkeeelvntlpvgkvk 104
                  +++ w++ k++ik+ ++ + +  ++ +k+k
  EFC37693.1 479 AQSQSWETIKQIIKEHRDVDPIAAMI-HKLK 508
                 46788999999999999999999988.7777 PP

  == domain 2  score: -5.1 bits;  conditional E-value: 4
     NFACT-C  67 kvdekeedke 76 
                 + de++++k+
  EFC37693.1 547 SDDEEKKEKK 556
                 2222222222 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.88
     NFACT-C  67 kvdekeedkeklwprekelikalkeeelvntl 98 
                 k++ + + k++++++e++++ + k++++ + +
  EFC37693.1 594 KEKAAFASKKAIKKTEQKTLESAKKSQIKSEI 625
                 22222333677777777777777777666555 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.44
     NFACT-C  65 kkkvdekeed.keklwprekelikalkeeel 94 
                 +++++++ +d k++l+++ek++++ lk++ +
  EFC37693.1 867 EEEEKTEGNDkKRALSAKEKKILQRLKKKGM 897
                 1222222222355667777888888877655 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 0.63
     NFACT-C  48 vKkGkavkeilekflk.......kkkkvdekeedkek 77 
                  KkG + + + e  ++       k++k+d k++d+e+
  EFC37693.1 893 KKKGMTEQAARELIISgqatedsKSQKEDAKKQDEET 929
                 5777777777777777555555422333333333322 PP

  == domain 6  score: -5.9 bits;  conditional E-value: 4
     NFACT-C   49 KkGkavkeilekflk.......................kkkkvdekeedkeklwprekelikalke 91  
                  K+Gk  k  +++  +                       + k+v++k+e++++ +++e+  ik++ +
  EFC37693.1  951 KRGKWKKLKTKYADQdeeerqvmielignkpkerpkedEMKQVQKKKEEEQRKKKQEQAEIKKFLA 1016
                  555554444444433666666666666666666666543355666666666666666555555444 PP

  == domain 7  score: 70.8 bits;  conditional E-value: 1.7e-23
     NFACT-C    2 aeelslldsLvgtplpeDeileaipvcAPyaaLqkykYkvKlqP.G.svKkGkavkeilekflkkkkkvdekeedkeklwprekelikalkeeelvn 96  
                  +e+l+ +dsL+g+p ++D+ l+aipvcAPy++L++y+YkvKl P G ++KkGk  ke+++ + +           ++k  p+ + +ik++ e+++  
  EFC37693.1 1028 KEKLTEIDSLTGQPRDDDIFLFAIPVCAPYTCLKNYTYKVKLVPaGtNTKKGKVGKEAIAIMRS-----------ESKNLPMVEACIKSIDEADIGG 1113
                  68999***************************************64468************999...........5677899999999999999999 PP

     NFACT-C   97 tlpvgkvkv 105 
                  +l+ g++++
  EFC37693.1 1114 CLV-GNCRI 1121
                  999.88887 PP

>> ASL_C  Adenylosuccinate lyase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.6     9e-05       0.4      42     101 ..     454     512 ..     425     518 .. 0.86
   2 ?    0.6   2.1      0.13   5.9e+02      73     109 ..     995    1034 ..     956    1038 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 9e-05
                 HHHHHHHHT-GGGGHHHHHHHHHHTT-TTHHHHHHHHHTTS---HHHHHHHHHCS-S-HH CS
       ASL_C  42 ealaedLdenwevlaEaiqtvlrregiekpYeklkeltrgkkitkeslkefieslevsee 101
                 e++a+ +++++e++  aiq++    + ++++e++k++ ++++ + + ++++i++l+++++
  EFC37693.1 454 ETIATLIETHYEIVDQAIQVICSALAQSQSWETIKQIIKEHR-DVDPIAAMIHKLKLESS 512
                 567778999****************************98765.66789999999998765 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.13
                  HHHHHHHTTS---HHHHHHHHHCS-S-...HHHHHHHHC- CS
       ASL_C   73 eklkeltrgkkitkeslkefieslevs...eeakeeLkal 109 
                  +k  e +r+kk++++++k+f+++ +++   +e+ke+L+++
  EFC37693.1  995 KKKEEEQRKKKQEQAEIKKFLADENIPfmdDEDKEKLTEI 1034
                  4455668999***********9998652226777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3012  (0.167996); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                       186  (0.0103743); expected 17.9 (0.001)
Passed Fwd filter:                        57  (0.00317921); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.75u 0.40s 00:00:02.15 Elapsed: 00:00:00.63
# Mc/sec: 5474.56
//
Query:       EFC37694.1  [L=301]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-33  116.2   0.1    2.6e-33  115.7   0.1    1.2  1  ParcG     Parkin co-regulated protein


Domain annotation for each model (and alignments):
>> ParcG  Parkin co-regulated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.7   0.1   1.4e-37   2.6e-33       1     182 [.     130     298 ..     130     299 .. 0.92

  Alignments for each domain:
  == domain 1  score: 115.7 bits;  conditional E-value: 1.4e-37
       ParcG   1 tsFravydrGdipirvehgskkkkiqWkveiekLdydalLplffdGlretkhpyrflategikdllea.ageekilpvlpklilplkeaLntrdeevie 98 
                 t+F  vy++G+ip+r++h++ +++++W+ ++  ++yd+l+ ++ dGlret+hpy f+ +++++++ +a ++ eki+p+l ++   ++ aL+++++ ++e
  EFC37694.1 130 TTFGGVYEAGGIPCRIHHTAAHMHLSWEKPLPDIPYDPLILTVSDGLRETDHPYIFIVQKAFEEMCKAeEAAEKIIPLLRQITSFIRMALQSKENVIFE 228
                 68999**************************************************************98999*************************** PP

       ParcG  99 saLkvlqklvkaseligeaLvpyyrqlLpvlnlfknkrvnlgdkidyrkkknikdliqetlellerngGe..dalinIkymiPtYe 182
                 +aL+++q+l   + ++g+a++p++  +L+ ++    k+         + +k+  + i + l+++e+++ +  ++ + Ik+++PtY 
  EFC37694.1 229 NALSAVQHL---TACVGDAIIPHLPLVLVQIS----KK---------TFDKKYANKIMDILQNIEQSCENsaEVVKLIKAKVPTYV 298
                 *********...9***************9999....44.........345677888999999999988651166889********5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1400  (0.0780858); expected 358.6 (0.02)
Passed bias filter:                      670  (0.0373696); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 1776.13
//
Query:       EFC37695.1  [L=820]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-68  231.1   0.1    2.1e-68  230.5   0.1    1.3  1  Pkinase         Protein kinase domain
      3e-39  134.9   0.0      5e-39  134.1   0.0    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
    4.2e-34  116.6   1.6    7.4e-16   58.1   0.1    3.0  2  POLO_box        POLO box duplicated region
    2.2e-05   23.9   0.0    4.4e-05   22.9   0.0    1.6  1  Kinase-like     Kinase-like
    0.00012   21.0   0.0    0.00012   21.0   0.0    2.3  2  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
       0.18   11.7   0.0       0.35   10.8   0.0    1.4  1  APH             Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  230.5   0.1   7.2e-72   2.1e-68       2     264 .]      91     344 ..      90     344 .. 0.95

  Alignments for each domain:
  == domain 1  score: 230.5 bits;  conditional E-value: 7.2e-72
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHH CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseee 99 
                  +++ lG+G+f+++y  ++  t+   A K+i+k+  +k++  +k+++Eiki+ +l+h++iv+++++fe+ +++y++le++++g+++dll+ ++ l+e+e
  EFC37695.1  91 YQERFLGKGGFAQCYLFRQVGTNIFHAAKIIDKKTLEKENVkQKLFSEIKIHSSLSHRHIVNFVRYFEDINNVYILLEVCNCGSMMDLLKSRTRLTEQE 189
                 57889**************************999877766569******************************************************** PP

                 HHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-ST CS
     Pkinase 100 akkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppf 197
                 a+++++qil +  y+ +k++iHrDlK  N+++ +k e+Ki+DFGla+e+e + + +++++gt++Y+APE+l ++++s +vD+Ws+Gvily++l g+ppf
  EFC37695.1 190 ARFFLHQILLACLYMNEKKVIHRDLKLGNLFLTDKMEIKIGDFGLATEVEFDGErKKTICGTPNYIAPEILYNKGHSFEVDIWSIGVILYTMLVGTPPF 288
                 *********************************9999*************888879******************************************* PP

                 TTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 198 sgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 + ++ ke+++k+ ++           + ++p + eis++ak+l++++l+++p +R+ ++ +l++p++
  EFC37695.1 289 ETKDVKETYKKIKHN-----------DYNFPPDIEISSKAKSLIRSILRRNPDDRPDIKTILSDPFF 344
                 *66666655555555...........99*************************************98 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  134.1   0.0   1.7e-42     5e-39       5     257 ..      94     340 ..      91     341 .. 0.90

  Alignments for each domain:
  == domain 1  score: 134.1 bits;  conditional E-value: 1.7e-42
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH..HHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateee..keelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekl 100
                  + lG+G f++ +  +       +++  a K++++++ e+e  k++l++e+ki ++l+h++iv+++    + ++++i++e ++ G++ + L+++  ++l
   EFC37695.1  94 RFLGKGGFAQCYLFRQV----GTNIFHAAKIIDKKTLEKEnvKQKLFSEIKIHSSLSHRHIVNFVRYFEDINNVYILLEVCNCGSMMDLLKSR--TRL 185
                  67999999998887777....66677777887665555544589***********************************************98..99* PP

                  BHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHH CS
  Pkinase_Tyr 101 tlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEi 198
                  t ++   f +q+  ++ y+++kk++Hrdl   N +l++++ +ki+DfGLa ++ + d  +kk+ +    +++apE+l +k  + + D+Ws Gv+l+ +
   EFC37695.1 186 TEQEARFFLHQILLACLYMNEKKVIHRDLKLGNLFLTDKMEIKIGDFGLATEV-EFDGERKKTIC-GTPNYIAPEILYNKGHSFEVDIWSIGVILYTM 281
                  *****************************************************.44444555545.5569***************************9 PP

                  HTTSSGTTTTSHHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 199 ftlgespypglkneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRptfselve 257
                  +  g  p+++ + +e+++k+ +++++ +   +++++ ++l+++ ++++p++Rp+++++++
   EFC37695.1 282 LV-GTPPFETKDVKETYKKIkHNDYNFPPDIEISSKAKSLIRSILRRNPDDRPDIKTILS 340
                  98.*****************677888999999***********************99975 PP

>> POLO_box  POLO box duplicated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.7   0.1   6.8e-19     2e-15       1      64 []     614     682 ..     614     682 .. 0.98
   2 !   58.1   0.1   2.5e-19   7.4e-16       1      63 [.     735     799 ..     735     800 .. 0.97

  Alignments for each domain:
  == domain 1  score: 56.7 bits;  conditional E-value: 6.8e-19
                 CTTSEEEEEETTS-EEEEETTTEEEEEETTTTEEEEE-T.......T--EEEEECCHHC--HHHHHHHHHH CS
    POLO_box   1 stkygigyqLsdgtvgVnFnDhtkiilspdgkavtyidr.......qgerstytlsesgcpeelkkkltll 64 
                 s kyg+ y++s+g+vg ++nD++k++  p ++++ y++r       ++erst+t+s  ++p++++kk+tl+
  EFC37695.1 614 SAKYGLTYLMSNGCVGAVYNDSSKMTYMPATEQINYYERkatgdniYEERSTFTVS--DFPPQMNKKVTLI 682
                 57********************************************9********9..***********96 PP

  == domain 2  score: 58.1 bits;  conditional E-value: 2.5e-19
                 CTTSEEEEEETTS-EEEEETTTEEEEEETTTTEEEEE-TT--EEEEECCH..HC--HHHHHHHHH CS
    POLO_box   1 stkygigyqLsdgtvgVnFnDhtkiilspdgkavtyidrqgerstytlse..sgcpeelkkkltl 63 
                 +t ++++++Ls++ v+V F+D t+iil  d++ v y d+qg r+ty l++  ++ ++e+ k+l++
  EFC37695.1 735 RTSHAVIFRLSNKIVQVCFHDQTEIILTGDSNLVSYTDPQGVRTTYALNKvvKSPSQEIAKRLKY 799
                 799************************************************888889*******9 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.0   1.5e-08   4.4e-05     128     288 .]     173     332 ..     124     332 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 1.5e-08
  Kinase-like 128 nkvlqkrsethkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvl.seve..kgfaPpEllgsrggytrk 222
                  +++++  +++ +  e+ ar  l  q++    ++ +k ++h +++  nl+l  k  +++g+f+    +   +    +++    +  pE+l ++g     
   EFC37695.1 173 GSMMDLLKSRTRLTEQEARFFL-HQILLACLYMNEKKVIHRDLKLGNLFLTDKMEIKIGDFGLATEVEFDGERkKTICgtPNYIAPEILYNKGH---- 265
                  4667777777778888899998.5566566799****************************866655444443224443344666676666555.... PP

  Kinase-like 223 nktkmthkldaWqlGlviyriwclklPltl.ateeakeew.....kfklckkipekvkaLlkkfLqlsqedR 288
                       ++++d W +G+  y +   + P++  + +e  ++      +f +  +i+ k k L++ +L+++ +dR
   EFC37695.1 266 -----SFEVDIWSIGVILYTMLVGTPPFETkDVKETYKKIkhndyNFPPDIEISSKAKSLIRSILRRNPDDR 332
                  .....9*********************964133333222233443999999****************99988 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   4.1e-08   0.00012     324     400 ..     205     274 ..      19     282 .. 0.90
   2 ?   -1.3   3.2      0.23   6.9e+02     220     291 ..     503     573 ..     466     596 .. 0.49

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 4.1e-08
  Pkinase_fungal 324 lkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhDLESf 400
                     ++++++HrD   +N+ +t     ++ +  + D+ la+e++ d ++  +++  GT++++a e+l ++ Hs+  D+ S+
      EFC37695.1 205 NEKKVIHRDLKLGNLFLT-----DKMEIKIGDFGLATEVEFDGER--KKTICGTPNYIAPEILYNKGHSFEVDIWSI 274
                     5789**************.....56778899*********85444..4689*************999*****99775 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.23
  Pkinase_fungal 220 eiRkgldvtkaekfrskrkvvsssssqelsskaevklkksesskkvekrsvdssvstskrsrlenrvhrrlv 291
                     ++ ++  ++++ ++ s+r+v+++++++ l++ ++ ++ + e ++k+++ +++ss++ts  + +  + +r  v
      EFC37695.1 503 HVTASSVTSSP-SLGSQRSVQTTQTTSRLPTPKRRSPSEDERKSKPQTPTSESSLETSRSKGPPVKKVRNTV 573
                     22222222222.444444444443333333222222222222222222333344433333333344444444 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00012      0.35     145     194 ..     182     233 ..     157     236 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00012
                 HHHHHHH.....HHHHHHHH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---T CS
         APH 145 leeleeq.....vlaalaallpgelptvllHgDlhpgNllvdpddgrvtGviDfe 194
                 + +l+eq     + + l+a l    ++ ++H+Dl++gNl ++ d+ ++  + Df+
  EFC37695.1 182 RTRLTEQearffLHQILLACLYM-NEKKVIHRDLKLGNLFLT-DKMEI-KIGDFG 233
                 44444444444488888888886.9999**************.76666.455555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (820 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1200  (0.0669307); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.76u 0.31s 00:00:01.07 Elapsed: 00:00:00.48
# Mc/sec: 5123.86
//
Query:       EFC37696.1  [L=505]
Description: hypothetical protein NAEGRDRAFT_74561 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.4e-17   61.1   3.1    9.4e-17   61.1   3.1    2.0  2  LRR_9           Leucine-rich repeat
    3.8e-08   33.5   3.9    1.8e-07   31.3   0.9    3.2  3  LRR_4           Leucine Rich repeats (2 copies)
    7.6e-06   25.6   1.5    0.00015   21.4   0.9    2.3  2  LRR_8           Leucine rich repeat
     0.0065   16.4   0.2        8.6    6.7   0.0    3.2  3  LRR_6           Leucine Rich repeat
  ------ inclusion threshold ------
        1.6    9.0   4.2         11    6.4   0.4    2.9  2  DUF948          Bacterial protein of unknown function (DUF948
        1.8    9.3   8.1         13    6.5   0.2    3.5  3  Ribosomal_S20p  Ribosomal protein S20


Domain annotation for each model (and alignments):
>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.1   3.1   3.2e-20   9.4e-17      23     165 ..      53     191 ..      41     202 .. 0.88
   2 ?   -2.3   0.0      0.87   2.6e+03      73      95 ..     353     375 ..     305     401 .. 0.62

  Alignments for each domain:
  == domain 1  score: 61.1 bits;  conditional E-value: 3.2e-20
       LRR_9  23 eldlrgykipvienlGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsll 121
                  l+  +  +++ie l  +      +dls n+i k++g+  lk lk l+l +n i +i eg+e+ l +l+++ +++n+++e + ++ l  +++l +++l 
  EFC37696.1  53 KLKRDTMDFALIEHLSFSFK--KKLDLSFNKITKIEGLKGLKNLKYLSLFSNDIEKI-EGMED-LMELKSFSIAKNKIKEKSSIQYLRMFPRLGMVTLY 147
                 55555666677777766654..4799******************************9.57766.669******************************** PP

       LRR_9 122 knpvtnkkeyrlyviyklkqlrlldfrkvklkereeaeklfksk 165
                 +npv++++++r++v+  l++l+ ld+r + ++e + a++ f+ +
  EFC37696.1 148 DNPVCEERDFRNMVLAFLRNLKFLDYRLIEEEEVQTAKERFHNE 191
                 *****************************************975 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.87
       LRR_9  73 nnrivriaegleevlPnleelvl 95 
                  n+     e +ee+lPn +e+  
  EFC37696.1 353 VNQSEAFWEVIEEFLPNYREMDC 375
                 33333444455555555555544 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.3   0.9     6e-11   1.8e-07       4      39 ..      73     107 ..      73     113 .. 0.84
   2 ?    0.7   0.0      0.27   7.9e+02       3      33 ..     116     149 ..     115     154 .. 0.69
   3 ?   -4.0   0.1         6   1.8e+04      22      29 ..     165     172 ..     162     172 .. 0.61

  Alignments for each domain:
  == domain 1  score: 31.3 bits;  conditional E-value: 6e-11
                 -EEE--SS---E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4   4 evLdLsnNqltdiplleklpnLkeLdLsgNnlitdl 39 
                 ++LdLs N++t+i++l++l+nLk+L+L +N  i+++
  EFC37696.1  73 KKLDLSFNKITKIEGLKGLKNLKYLSLFSN-DIEKI 107
                 68*************************445.45555 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.27
                 --EEE--SS---E-S-...HHH-TT--EEE-.-S CS
       LRR_4   3 LevLdLsnNqltdipl...leklpnLkeLdLsgN 33 
                 L++ +++ N++++ ++   l+ +p L  ++L +N
  EFC37696.1 116 LKSFSIAKNKIKEKSSiqyLRMFPRLGMVTLYDN 149
                 7888889899995444355667888777777555 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 6
                 -TT--EEE CS
       LRR_4  22 lpnLkeLd 29 
                 l nLk Ld
  EFC37696.1 165 LRNLKFLD 172
                 55666665 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.9   5.1e-08   0.00015      28      61 .]      73     104 ..      70     104 .. 0.95
   2 ?    0.4   0.0      0.19   5.7e+02      23      41 ..     112     130 ..     107     137 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 5.1e-08
                 -EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  28 kvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 k LdLs N++t ++   + gL++L++L L +N++
  EFC37696.1  73 KKLDLSFNKITKIE--GLKGLKNLKYLSLFSNDI 104
                 78***********6..****************97 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.19
                 T-TT--EEE--SS---GGG CS
       LRR_8  23 glsnLkvLdLsnNllttls 41 
                 +l  Lk++++  N+++  s
  EFC37696.1 112 DLMELKSFSIAKNKIKEKS 130
                 5678999999999999765 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0029       8.6       6      16 ..      73      83 ..      73      85 .. 0.91
   2 !    6.1   0.1    0.0044        13       4      16 ..      93     105 ..      90     107 .. 0.89
   3 ?   -2.7   0.0       2.9   8.7e+03       5      15 ..     116     126 ..     115     127 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0029
       LRR_6  6 teLdLsgNdIg 16
                ++LdLs+N+I+
  EFC37696.1 73 KKLDLSFNKIT 83
                68********8 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0044
       LRR_6   4 hLteLdLsgNdIg 16 
                 +L++L+L +NdI 
  EFC37696.1  93 NLKYLSLFSNDIE 105
                 8**********95 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 2.9
       LRR_6   5 LteLdLsgNdI 15 
                 L++ +++ N+I
  EFC37696.1 116 LKSFSIAKNKI 126
                 899999***99 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.3     0.048   1.4e+02      29      64 ..     299     332 ..     286     352 .. 0.79
   2 ?    6.4   0.4    0.0035        11      43      75 ..     399     431 ..     376     441 .. 0.59

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.048
      DUF948  29 deaaatieelekqvdpilkevedllakvnelledvn 64 
                 ++ ++ i+e ek+ ++i+ +v++++a+++e  ed++
  EFC37696.1 299 SSSKTLIKEFEKKKKEIISNVKEMTAESEE--EDLH 332
                 4556778999999999********999998..5544 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0035
      DUF948  43 dpilkevedllakvnelledvneklekvdplte 75 
                 d ++++v+++ + +ne ++d+ e  +++ +l++
  EFC37696.1 399 DRLMDQVTTIAEDTNEKVKDILEDKDQLFTLVQ 431
                 445666666666666644444444444444443 PP

>> Ribosomal_S20p  Ribosomal protein S20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.4    0.0082        25      15      41 ..     293     326 ..     271     349 .. 0.71
   2 ?   -1.2   0.1       1.1   3.3e+03      24      43 ..     376     393 ..     369     420 .. 0.68
   3 ?    6.5   0.2    0.0044        13      12      40 ..     463     491 ..     460     501 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0082
                     HHHHHHHHHHHHHHHHHHHHHHHHHC.......- CS
  Ribosomal_S20p  15 krrlrNrsyksavrtaiKkvraaiea.......d 41 
                     ++ + N s k+ ++ + Kk ++ i++       +
      EFC37696.1 293 SQYETNSSSKTLIKEFEKKKKEIISNvkemtaeS 326
                     5566788888888888888888886665553322 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.1
                     HHHHHHHHHHHHHHHHC-HH CS
  Ribosomal_S20p  24 ksavrtaiKkvraaieadke 43 
                      s++ ++ Kk+++    dk+
      EFC37696.1 376 TSKIQNFFKKLKKIE--DKY 393
                     688889999988866..333 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0044
                     HHHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
  Ribosomal_S20p  12 qnekrrlrNrsyksavrtaiKkvraaiea 40 
                     +++ +++rNrs+ s++ t++ +v++ ie+
      EFC37696.1 463 TKKDEHERNRSRISEIWTFVERVKEEIEE 491
                     6778899*******************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2865  (0.159797); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.53u 0.24s 00:00:00.77 Elapsed: 00:00:00.41
# Mc/sec: 3688.06
//
Query:       EFC37697.1  [L=378]
Description: VWFA domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.1e-21   76.6   0.0    1.2e-20   74.1   0.0    2.2  2  VWA_2        von Willebrand factor type A domain
    3.3e-05   23.8   0.0    7.2e-05   22.7   0.0    1.5  2  Ssl1         Ssl1-like
     0.0095   15.8  13.0      0.018   14.9   6.6    4.7  5  UIM          Ubiquitin interaction motif


Domain annotation for each model (and alignments):
>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.1   0.0   2.1e-24   1.2e-20       2     103 ..       6     114 ..       5     118 .. 0.88
   2 ?   -0.9   0.0      0.42   2.5e+03      73      93 ..     318     338 ..     292     345 .. 0.70

  Alignments for each domain:
  == domain 1  score: 74.1 bits;  conditional E-value: 2.1e-24
       VWA_2   2 vfvlDtSgSmrngdygptrleaakdaveallk....slpgdrvglvtfsd.gpevlipltkdkakilnalrnleakgggtnlaaaLqlarkalkkrr.. 93 
                 ++++D+S++mrngdy ptrl+a+ +a++ +++    s+p++++g++t++d +p v++ +t+d +k+l+ l ++   gg+t++ +aLq a  +lk+r   
  EFC37697.1   6 MICIDNSEWMRNGDYAPTRLDAQLEAANLICGsktqSNPETTIGVLTMGDsNPSVKVAPTTDLGKLLSSLSSVSV-GGDTHFSKALQIAYLVLKNRApe 103
                 89******************************6665559***********99**********************8.6*****************99889 PP

       VWA_2  94 .kgekrvivli 103
                   + +r++v++
  EFC37697.1 104 qGTPNRRLVIF 114
                 73333444433 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.42
       VWA_2  73 gggtnlaaaLqlarkalkkrr 93 
                 + +  l+aaL++ +++ kk+ 
  EFC37697.1 318 DEDAALEAALRMSMEESKKND 338
                 455667777777777766654 PP

>> Ssl1  Ssl1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   1.2e-08   7.2e-05       2     138 ..       9     145 ..       8     151 .. 0.84
   2 ?   -3.9   0.1       1.6   9.8e+03      73      92 ..     314     333 ..     309     336 .. 0.77

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 1.2e-08
                 EE-SGGGGSSSSSS-HHHHHHHHHHHHHHHHHHHSTT-EEEEEEEETTEEEEEEEEES-HHHHHHHHHHHTTS---S---HHHHHHHHHHHHSSS.-.. CS
        Ssl1   2 lDlsrameekdlkpsrlavviklleefveeffdqnPisqlgliavkdkkaekltelsGnprkhikaLkslreveakgepsLqnaLelalasLkkv.p.. 97 
                 +D s+ m + d  p+rl+ ++++++       + nP + +g++++ d         +    ++ k L sl  v++ g++    aL++a   Lk+  p  
  EFC37697.1   9 IDNSEWMRNGDYAPTRLDAQLEAANLICGSKTQSNPETTIGVLTMGDSNPSVKVAPTT---DLGKLLSSLSSVSVGGDTHFSKALQIAYLVLKNRaPeq 104
                 8********************************************9987653333333...3445566667777***************9998751422 PP

                 TTSEEEEEEEE-SS----SS-HHHHHHHHHHTT-EEEEEEE CS
        Ssl1  98 shasrevliifsslstcDPgdiyetidelkkekirvsvigL 138
                 +  +r ++i ++s    +  d++++  ++kk+ + + vi  
  EFC37697.1 105 GTPNRRLVIFVGSPIEENKDDLVKLGLRMKKNGVACDVINF 145
                 45579*********************************975 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 1.6
                 TS---S---HHHHHHHHHHH CS
        Ssl1  73 eveakgepsLqnaLelalas 92 
                 e e+  +++L+ aL +++++
  EFC37697.1 314 EEEMDEDAALEAALRMSMEE 333
                 56778899999999999876 PP

>> UIM  Ubiquitin interaction motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.4   1.8e-05       0.1       3      16 ..     226     239 ..     226     239 .. 0.94
   2 ?   -2.1   0.6      0.85   5.1e+03       1       7 [.     283     289 ..     283     290 .. 0.79
   3 !    6.4   3.4    0.0016       9.4       1      17 []     291     307 ..     291     307 .. 0.94
   4 ?   -5.2   3.0         3   1.8e+04       2       5 ..     313     316 ..     312     317 .. 0.47
   5 !   14.9   6.6     3e-06     0.018       1      17 []     318     334 ..     318     334 .. 0.96

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.8e-05
         UIM   3 dedLqrAlalSlqE 16 
                 d +L++A++lSl+E
  EFC37697.1 226 DPELAMAIRLSLEE 239
                 789**********9 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.85
         UIM   1 dEdedLq 7  
                 ++d+d++
  EFC37697.1 283 TDDDDIE 289
                 6899996 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0016
         UIM   1 dEdedLqrAlalSlqEa 17 
                 ++de L++Al lS qEa
  EFC37697.1 291 EDDEALEKALLLSKQEA 307
                 69**************6 PP

  == domain 4  score: -5.2 bits;  conditional E-value: 3
         UIM   2 Eded 5  
                 E+e+
  EFC37697.1 313 EEEE 316
                 5554 PP

  == domain 5  score: 14.9 bits;  conditional E-value: 3e-06
         UIM   1 dEdedLqrAlalSlqEa 17 
                 dEd+ L++Al++S++E+
  EFC37697.1 318 DEDAALEAALRMSMEES 334
                 8***************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1370  (0.0764125); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 2231.67
//
Query:       EFC37698.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    9.7e-68  224.2   5.0    1.1e-25   89.4   0.2    3.1  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   89.4   0.2   5.9e-30   1.1e-25       6      96 ..      39     135 ..      35     136 .. 0.95
   2 !   74.1   0.1   3.6e-25   6.5e-21       3      96 ..     141     239 ..     139     240 .. 0.89
   3 !   62.0   0.1   2.1e-21   3.8e-17       4      96 ..     248     339 ..     245     340 .. 0.89

  Alignments for each domain:
  == domain 1  score: 89.4 bits;  conditional E-value: 5.9e-30
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS......HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCTT CS
   Mito_carr   6 lkellaGglagavatlvttPldvvKtrlqtqkksskksksaa......ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllkk 96 
                 + ++laGg++g++a+++t+Pldv+Ktr+q++++ +++++ ++      i+d lk + ++eG++gl+rGl+pn+++++p++a++f++y   k+++ k+
  EFC37698.1  39 TINFLAGGISGSIAAVATQPLDVLKTRFQSSAGIYNETTAQSrffltkIIDSLKVTARNEGMHGLFRGLIPNIVGIFPSRAIYFATYSAAKDFFSKY 135
                 568*****************************999998887799**************************************************986 PP

  == domain 2  score: 74.1 bits;  conditional E-value: 3.6e-25
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS......HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCT CS
   Mito_carr   3 lsvlkellaGglagavatlvttPldvvKtrlqtqkksskksksaa......ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllk 95 
                  s++ ++++++++g+v    ++P+ +vKtr+q++++s +++  ++       +d++kkiyk+eG+ g+y+Gl++++l+++ ++a++fvlye++k + +k
  EFC37698.1 141 ESPIVHIASAAACGVVVPGTMNPMFLVKTRIQLDQHSRNQTPGSNtpgyngYADCIKKIYKNEGIGGFYKGLTASFLGIF-ETAIYFVLYEQVKAFAQK 238
                 5778899**************************887765544444578888*****************************.*************99888 PP

                 T CS
   Mito_carr  96 k 96 
                 +
  EFC37698.1 239 S 239
                 6 PP

  == domain 3  score: 62.0 bits;  conditional E-value: 2.1e-21
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCTT CS
   Mito_carr   4 svlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllkk 96 
                 ++l ++  +g ++++a+ +t+P +vv+tr+    + +   + +++++++k+i  eeG +gly+G+++ l+rv+p++a++f+++e++ +++ k+
  EFC37698.1 248 TPLTYITLSGSCKLIASALTYPHEVVRTRMREIVNGKCR-YDKGMINAFKTIAVEEGTKGLYSGMGAHLVRVVPTTAIMFLSFEFIVHFMEKH 339
                 567788899999******************987766554.4455*******************************************999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       681  (0.0379832); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 2000.29
//
Query:       EFC37699.1  [L=348]
Description: vWFA domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.8e-11   44.6   0.0    4.6e-11   43.3   0.0    1.6  2  VWA_2      von Willebrand factor type A domain
    1.2e-08   35.4   0.0    1.9e-08   34.8   0.0    1.3  1  VWA        von Willebrand factor type A domain
    2.1e-05   24.5   0.0    4.4e-05   23.4   0.0    1.5  1  Med25_VWA  Mediator complex subunit 25 von Willebrand factor 
    0.00046   18.3   0.1    0.00075   17.6   0.1    1.3  1  TssR       Type VI secretion system, TssR
  ------ inclusion threshold ------
      0.045   13.7   0.0       0.12   12.3   0.0    1.7  1  VWA_3      von Willebrand factor type A domain
      0.072   13.5   1.7       0.12   12.7   0.7    1.9  2  YtzH       YtzH-like protein


Domain annotation for each model (and alignments):
>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.3   0.0   1.5e-14   4.6e-11       1     106 [.      38     147 ..      38     148 .. 0.91
   2 ?   -3.1   0.0       4.2   1.3e+04      29      56 ..     202     233 ..     195     260 .. 0.52

  Alignments for each domain:
  == domain 1  score: 43.3 bits;  conditional E-value: 1.5e-14
       VWA_2   1 lvfvlDtSgSmrngdygptrleaakdaveallksl....pgd.rvglvtfsdg....pevlipltkdkakilnalrnleakgggtnlaaaLqlarkalk 90 
                 lv+v+D++ Sm+++      + +akd v++++ +l    + d r++ v+++d+    + ++ p+tk+ +k + +++++ ak gg ++ +aL  a k+++
  EFC37699.1  38 LVIVMDNTSSMSGE------IKIAKDTVQSIITTLhdhfQSDlRFSAVSYRDHtddyVVKEYPFTKNVEKAKGYVNEMFAK-GGGDMPEALASALKVVN 129
                 79***********8......99******999997766667668*********534557999******************97.***************** PP

       VWA_2  91 krr..kgekrvivlitDg 106
                 + +  k+ +++ ++i+D+
  EFC37699.1 130 EIPfnKKGRKICIWIADA 147
                 9999999*********96 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 4.2
       VWA_2  29 eallksl..pgd.rvglvtfsdg.pevliplt 56 
                 + +++ l  ++d +++l+t +++ p+++i+ +
  EFC37699.1 202 SLFMDYLatKTDgKCMLLTEANKiPNLIINGC 233
                 44555443233346666666664255655554 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.8   0.0   6.2e-12   1.9e-08       1     167 [.      37     223 ..      37     229 .. 0.81

  Alignments for each domain:
  == domain 1  score: 34.8 bits;  conditional E-value: 6.2e-12
                 EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHT.BTTTTEEEEEEEESSS....EEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHH CS
         VWA   1 DivfvlDgSgsmgeenfekvkefikklvekle.vgpegtrvglvqfsse....vktefslndysskeellsalnnlkysgggttntgkalkyaleklfk 94 
                 D+v+v+D+ +sm  ++++ +k+ +++++  l    + + r++ v++ ++    v  e+++++  + e+++ ++n++  +ggg+  + +al+ al+ + +
  EFC37699.1  37 DLVIVMDNTSSM-SGEIKIAKDTVQSIITTLHdHFQSDLRFSAVSYRDHtddyVVKEYPFTK--NVEKAKGYVNEMFAKGGGD--MPEALASALKVVNE 130
                 9***********.9999999999999999999668899*********8878889999****9..66*********75555555..5************* PP

                 HHGTSSTTSEEEEEEEES..........S--CSS.............HTHHHHHHHHGCTEEEEEEEESSSHHHHHHHHH....SSSSCHHCEEEESSH CS
         VWA  95 ssagaRenakkviilltd..........Gksndg.............dpkeaaneakeqgikvfavGvgnadekelLnki....asepgeghvftvtdf 166
                    +++   +k+ i ++d                             d  + a  ++e+++ ++++ +g   ++++L  +    a++++ g+ + +t+ 
  EFC37699.1 131 IPFNKK--GRKICIWIADapphgmgasgD----YfpdgckdeqgeiiDWIKLASHLQEKNVVFYSIICGRSKNDQQLSLFmdylATKTD-GKCMLLTEA 222
                 **9955..5*********99998855540....2444566666799999*******************888888878776666666666.555555555 PP

                 H CS
         VWA 167 e 167
                 +
  EFC37699.1 223 N 223
                 5 PP

>> Med25_VWA  Mediator complex subunit 25 von Willebrand factor type A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.0   1.5e-08   4.4e-05      62     177 ..      80     195 ..      32     215 .. 0.84

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 1.5e-08
   Med25_VWA  62 kaadslpeplvqlsgptssvekllqwldkiefsGgggesvaliaEGLatalqlfddlkqirepssavqkhciLvcnspPyrlpvvesvkytg....... 153
                 +  d++ + +v+ ++ t++vek    ++++  +Ggg      + E La+al++++++   +    + +k ci ++  pP+ + +   +   g       
  EFC37699.1  80 SYRDHTDDYVVKEYPFTKNVEKAKGYVNEMFAKGGGD-----MPEALASALKVVNEIPFNK----KGRKICIWIADAPPHGMGASGDYFPDGckdeqge 169
                 556888889999999*************999999974.....5577**********98884....589**************99999888887777777 PP

   Med25_VWA 154 .ktaeqlaallaernisl.SiispRk 177
                   +  +la+ l+e+n+ + Sii+ R 
  EFC37699.1 170 iIDWIKLASHLQEKNVVFySIICGRS 195
                 777778*******998766****995 PP

>> TssR  Type VI secretion system, TssR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.1   2.5e-07   0.00075     302     379 ..      36     112 ..      27     139 .. 0.83

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 2.5e-07
        TssR 302 iNivFvidgssemkkylpqlvnliqsLetkfekssrktsvkfGavvykddrgnkkpgtsslstdykkllsfLekeaks 379
                 + +v v+d+ s+m+ +++  ++++qs+ t++ +   +++++f+av y+d+++ +++ +  ++++++k     ++++++
  EFC37699.1  36 VDLVIVMDNTSSMSGEIKIAKDTVQSIITTLHD-HFQSDLRFSAVSYRDHTDDYVVKEYPFTKNVEKAKGYVNEMFAK 112
                 66789****************************.8899**********************999999877666666554 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0     4e-05      0.12       2      89 ..      37     126 ..      36     142 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4e-05
       VWA_3   2 evvivvDvsssmsaenklvkdaLsvalrqLptnd....kiavllfgtkprplfpgsravsaaelqealqkikelelslgasnlegaLkealr 89 
                 ++viv+D +ssms+e+k +kd+ + ++ +L +      +++ ++ ++ ++    +      + +++a+ +++e+++ +g+ ++  aL+ al+
  EFC37699.1  37 DLVIVMDNTSSMSGEIKIAKDTVQSIITTLHDHFqsdlRFSAVSYRDHTDDYVVKEYPFT-KNVEKAKGYVNEMFA-KGGGDMPEALASALK 126
                 79**************99999999999998765300135555555555554554444444.677888888888888.888888888887775 PP

>> YtzH  YtzH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       4.2   1.3e+04      38      58 ..      48      69 ..      44      75 .. 0.58
   2 ?   12.7   0.7   4.1e-05      0.12       3      73 ..     197     268 ..     196     276 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 4.2
        YtzH 38 llaneev.dedvkqvLeeiYay 58
                +  + ++ ++ v+++++ + ++
  EFC37699.1 48 MSGEIKIaKDTVQSIITTLHDH 69
                4555555455566666666555 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 4.1e-05
        YtzH   3 nehqltlLkDiLkeqqadccgtvseceQierlv.ksllaneevdedvkqvLeeiYaysqegkssqsldnhie 73 
                 n++ql+l  D L  + + +c+ + e++ i  l+ +  +++e++d+ v + ++e+ + + ++ ++++l +h++
  EFC37699.1 197 NDQQLSLFMDYLATKTDGKCMLLTEANKIPNLIiNGCIEDEQMDRLVEERIKELGKENAKAMKEEELIAHVH 268
                 678**************************998625699***********99999777777777777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       762  (0.042501); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 2045.56
//
Query:       EFC37700.1  [L=482]
Description: hypothetical protein NAEGRDRAFT_81854 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-12   47.3   5.7    1.6e-12   47.3   5.7    2.6  3  WW        WW domain


Domain annotation for each model (and alignments):
>> WW  WW domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.5      0.47   8.5e+03      13      17 ..     122     126 ..     117     132 .. 0.61
   2 ?   -6.3   2.9         1   1.8e+04      18      23 ..     151     156 ..     151     157 .. 0.76
   3 !   47.3   5.7   8.8e-17   1.6e-12       1      31 []     452     482 .]     452     482 .] 0.99

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.47
                 TT-EE CS
          WW  13 sGrvY 17 
                 +G++Y
  EFC37700.1 122 TGKYY 126
                 46555 PP

  == domain 2  score: -6.3 bits;  conditional E-value: 1
                 EEETTT CS
          WW  18 YyNheT 23 
                 YyN ++
  EFC37700.1 151 YYNNNN 156
                 999876 PP

  == domain 3  score: 47.3 bits;  conditional E-value: 8.8e-17
                 X-TTEEEEE-TTTT-EEEEETTT--EESS-- CS
          WW   1 LPpGWeeqwdpdsGrvYYyNheTgetqWekP 31 
                 LP+GW++++d+++G++YY+N++T +tqWe+P
  EFC37700.1 452 LPSGWKQYFDDKTGKYYYHNERTDTTQWERP 482
                 8*****************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (482 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2280  (0.127168); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                        28  (0.00156172); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.10u 0.40s 00:00:01.50 Elapsed: 00:00:00.57
# Mc/sec: 2554.33
//
Query:       EFC37701.1  [L=613]
Description: hypothetical protein NAEGRDRAFT_81857 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.1e-23   82.2   8.8    1.1e-20   74.2   6.1    2.7  2  C9orf72-like  C9orf72-like protein family
  ------ inclusion threshold ------
        3.8    6.9  13.5        6.8    6.0  13.5    1.3  1  SelP_N        Selenoprotein P, N terminal region


Domain annotation for each model (and alignments):
>> C9orf72-like  C9orf72-like protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.2   6.1   1.2e-24   1.1e-20      35     242 ..     193     445 ..     172     447 .. 0.83
   2 !    7.6   0.0   0.00028       2.6     105     177 ..     536     608 ..     486     610 .. 0.76

  Alignments for each domain:
  == domain 1  score: 74.2 bits;  conditional E-value: 1.2e-24
  C9orf72-like  35 vvsfiFsankkggktlyalslilpekelakylplielcedrlkdiikklrallkkekpeekltrv...tdeiqrilellsslesssvpeeidfpldi 128
                   ++ ++F+ + +   tl+++s+++++++l+k++ +  +++++l +++k ++ + ++  + +++  +   ++++ ++++l +sl +    +++  ++++
    EFC37701.1 193 TSRSFFRRKVDPPPTLFTISIVMNRENLSKFMVINFIMKEKLITLAKIMKHFADQYTNSNQNEVIsnfENHLHEFVQLYDSLSRIVY-SPP--SMNL 286
                   556899**********************************99888887777766655555553335569999999998888876544.555..3566 PP

  C9orf72-like 129 adTvlaeekskds......enkFlskaitsHLqtqgttiieg..sskeevnkllntLalFllpeerklsslelrdks.................... 197
                    +T++ ee s +       e+ Fl++ai+sHL+t g+++++g  +   e+n  +ntLa+Fl++ e++l +++ + +                     
    EFC37701.1 287 YTTLFSEEISLKRlyeseeESIFLQRAISSHLETHGYSVVVGlpNQLREINVWVNTLAMFLSQHEKQLIKHAKKIEAtklpteiqtvvktsffkras 383
                   6566666554443677787999********************6667788*********************999988889****************** PP

  C9orf72-like 198 ...........yepgLfLQgvlkqatgspvs......qlltskrPtTlidldektVkqtppi 242
                               +p+ f+Qg++   + s  +       ll+ ++P+ +idl++++V++  ++
    EFC37701.1 384 apvkmldpenlFKPEIFVQGLVVTPDVSHWKdliptkSLLSGRYPISVIDLKDRKVYSFKKY 445
                   *********************9888877666889999********************97766 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00028
  C9orf72-like 105 rilellsslesssvpeeidfpldiadTvlaeekskdsenkFlskaitsHLqtqgttiiegsskeevnkllntL 177
                   + ++ +++++ +++++++   + i++ v +     ++++ +  +a +  Lq  ++ti+ g+  +e+++++n+L
    EFC37701.1 536 HSMRNVEMIAPAKIQKVLVKHVMINNSVQKYRPDDLTSELMAITATAEKLQHGVYTIVTGDPRQEAEDVVNFL 608
                   5566777777777777776555666544444444444666666677778***********************9 PP

>> SelP_N  Selenoprotein P, N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0  13.5   0.00076       6.8     158     217 ..      26      84 ..      16      97 .. 0.45

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.00076
      SelP_N 158 seaeeeckevtkaaeekpaeaeektehehahshkqghkhhekhghhHkekeelsesqqee 217
                 + +e++++++ +++++ +  ++    +++++++ + h+h+++ +h+H + ++ ++++++ 
  EFC37701.1  26 NDDEDFNSNTRSEEVTSSVATSTILMDRQQNQQ-HHHHHQSNNHHNHDSPQSNNNNNDQR 84 
                 556777777666555555555444333333222.22333333333333322222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (613 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1800  (0.100396); expected 358.6 (0.02)
Passed bias filter:                      593  (0.0330749); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.34s 00:00:01.08 Elapsed: 00:00:00.53
# Mc/sec: 3452.85
//
Query:       EFC37702.1  [L=321]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    8.9e-23   80.7   0.0    1.5e-22   79.9   0.0    1.3  1  Ras         Ras family
    2.3e-15   56.9   0.0      5e-15   55.8   0.0    1.6  1  Roc         Ras of Complex, Roc, domain of DAPkinase
    3.6e-13   49.4   0.1    6.4e-13   48.5   0.1    1.4  1  Arf         ADP-ribosylation factor family
    3.3e-05   23.3   0.0    5.1e-05   22.7   0.0    1.3  1  Gtr1_RagA   Gtr1/RagA G protein conserved region
    3.6e-05   23.6   0.0    6.6e-05   22.7   0.0    1.4  1  F-box-like  F-box-like
    0.00028   20.7   0.0    0.00053   19.8   0.0    1.4  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.027   15.0   0.4      0.055   14.0   0.3    1.7  1  ABC_tran    ABC transporter
      0.032   13.7   0.1      0.073   12.5   0.1    1.5  1  SMC_N       RecF/RecN/SMC N terminal domain
       0.05   13.8   0.1       0.84    9.8   0.0    2.1  2  DUF4987     Domain of unknown function
       0.11   12.1   0.1       0.21   11.2   0.1    1.4  1  FTA2        Kinetochore Sim4 complex subunit FTA2
       0.11   12.2   0.0       0.28   11.0   0.0    1.7  1  AAA_29      P-loop containing region of AAA domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.9   0.0   9.1e-26   1.5e-22       1     147 [.     116     285 ..     116     298 .. 0.85

  Alignments for each domain:
  == domain 1  score: 79.9 bits;  conditional E-value: 9.1e-26
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievd.gkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeik 98 
                 K vl+G ++ GK+ ++ r v ++F+ +y++Tigv+f +   +++ g +vk++ wD  G+  f+sl ++y r++++i  ++d++++esf+++k+ ve  +
  EFC37702.1 116 KTVLLGPEGSGKSEIVARIVGKDFDPTYTPTIGVEFAMVPYQLStGINVKMQYWDASGKPTFNSLSRAYTRGVHVIGFCFDLNNEESFSEMKNRVEIYR 214
                 89***********************************9999988799******************************************9998765433 PP

                 HHST............TTSEEEEEEETTTGGG...........G-SS-HHHHHHHHHHHTSEEEEEBTTTTC CS
         Ras  99 rvae............envpivLvGnKvDlee...........kravsteegeelakelglkfletSAktne 147
                 +  +            en +++++G K Dle+           ++ ++ ++   l k+l ++++e S kt++
  EFC37702.1 215 NE-NfsnlkwnanlkeENAHLLILGMKRDLERkvsiqqvkeyiSELIQVKKEGILLKDLRIQYFELSNKTDT 285
                 33.224566888899999*************76666666666655555555555669999999999999864 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.8   0.0   3.1e-18     5e-15       1     105 [.     116     213 ..     116     243 .. 0.82

  Alignments for each domain:
  == domain 1  score: 55.8 bits;  conditional E-value: 3.1e-18
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHHHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssenlkeWl 99 
                 K vl+G +g+GK+ ++ r+v ++f++++++tigv+f+   + ++++        +vk++ WD +G+  f+sl + y r+ +++ +++d +++e+++e  
  EFC37702.1 116 KTVLLGPEGSGKSEIVARIVGKDFDPTYTPTIGVEFAMVPY-QLST------GINVKMQYWDASGKPTFNSLSRAYTRGVHVIGFCFDLNNEESFSEMK 207
                 889*********************************98765.3322......23589*******************************66555554444 PP

                 HHHHHH CS
         Roc 100 kelkkv 105
                 + ++ +
  EFC37702.1 208 NRVEIY 213
                 444443 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.5   0.1   3.9e-16   6.4e-13      12     141 ..     112     257 ..     100     286 .. 0.82

  Alignments for each domain:
  == domain 1  score: 48.5 bits;  conditional E-value: 3.9e-16
                 TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEEEEE.....TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHH CS
         Arf  12 kkelrilllGLDnaGKtTilkklkleelvt.tvPTigfnveelei.....knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeL 104
                 k  ++ +llG +++GK+ i+ ++  ++++   +PTig +   + +      n+k++ wD  G+ +  +l + Y++ ++++ f+ D +++e ++e+k+ +
  EFC37702.1 112 KAFTKTVLLGPEGSGKSEIVARIVGKDFDPtYTPTIGVEFAMVPYqlstgINVKMQYWDASGKPTFNSLSRAYTRGVHVIGFCFDLNNEESFSEMKNRV 210
                 455789*********************985379**********996666669*************************************9999999876 PP

                 HHHCTSGCCT...........TSEEEEEEE-TTSTTSS-HHHHHHHTT CS
         Arf 105 kalleeeelk...........evallvlaNKqDlpealseeelrellg 141
                 +   +e+  +           +++ll+l+ K Dl+  +s ++++e ++
  EFC37702.1 211 EIYRNEN-FSnlkwnanlkeeNAHLLILGMKRDLERKVSIQQVKEYIS 257
                 5443332.22233445555779********************999764 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   3.1e-08   5.1e-05       2     155 ..     117     277 ..     116     286 .. 0.73

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 3.1e-08
   Gtr1_RagA   2 vLLmGksgsGKtsm.rsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesr....eleedl 95 
                  +L+G++gsGK+ +  +i+ + + ++ t ++g+   +   ++ +  n++++ wD  G+ +f        +    r v v+ + fD +++    e+++ +
  EFC37702.1 117 TVLLGPEGSGKSEIvARIVGKDFDPTYTPTIGVEFAMVPYQLSTGINVKMQYWDASGKPTFNS-----LSRAYTRGVHVIGFCFDLNNEesfsEMKNRV 210
                 679*********9835688899***********************************987754.....4677889************774444466666 PP

   Gtr1_RagA  96 etlke.ilealr....qyspeakvfvlihKmDliqedereeifeerkeeireeiekleke..eiqff 155
                 e +++  +++l+      +++a++ +l  K Dl ++   +++ e ++e i+ + e +  +  +iq+f
  EFC37702.1 211 EIYRNeNFSNLKwnanLKEENAHLLILGMKRDLERKVSIQQVKEYISELIQVKKEGILLKdlRIQYF 277
                 6665313444431110446788888888899988777777777666666666665444334455555 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0     4e-08   6.6e-05       3      33 ..      71     101 ..      70     106 .. 0.93

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 4e-08
  F-box-like   3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrr 33 
                  LP+E+ ++I+ yL  s+++ l ++C+ +++
  EFC37702.1  71 ELPHELFIHILGYLTGSEIVKLGRTCKNFQN 101
                 59*************************9976 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.0   3.3e-07   0.00053       5      39 ..      71     105 ..      70     110 .. 0.93

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 3.3e-07
                 HS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTT CS
       F-box   5 rLPsevlrhILerLplsdllalrrVSkgwrilids 39 
                 +LP e+  hIL +L  s+++ l r++k++ +  ++
  EFC37702.1  71 ELPHELFIHILGYLTGSEIVKLGRTCKNFQNSFKR 105
                 69***************************998776 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.3   3.4e-05     0.055       7      34 ..     110     137 ..     107     243 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.4e-05
                 EEETTSEEEEEESTTSSHHHHHHHHTTS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   7 klkegekvaivGenGaGKStLlkllagl 34 
                 ++k+ +k++++G+ G+GKS +++ + g+
  EFC37702.1 110 QIKAFTKTVLLGPEGSGKSEIVARIVGK 137
                 688999****************999886 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   4.5e-05     0.073      10      44 ..     103     134 ..      95     137 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.5e-05
                 ETTEECEEEEEETTSSEEEEEESTTSSHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N  10 FksyagktvilpfsksftaivGpNGSGKsnlldAi 44 
                 Fk   ++++i  f+k  t+++Gp GSGKs ++  i
  EFC37702.1 103 FKRS-DEKQIKAFTK--TVLLGPEGSGKSEIVARI 134
                 4443.3556666666..89************9766 PP

>> DUF4987  Domain of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.16   2.6e+02      36      64 ..     108     140 ..      95     148 .. 0.81
   2 ?    9.8   0.0   0.00052      0.84      59     129 ..     158     225 ..     146     242 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.16
     DUF4987  36 ek....vsvdvtiepevegesfllkglvggdfd 64 
                 ek     +  v + pe  g+s ++  +vg dfd
  EFC37702.1 108 EKqikaFTKTVLLGPEGSGKSEIVARIVGKDFD 140
                 334445788999********************9 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00052
     DUF4987  59 vggdfdillgYDkasGrLvlnsqsigavssnsvwlaaldlkagGvlnta.selglvtklnkdlsnvvltwnt 129
                 +++  ++ ++Y  asG+ ++ns s + + ++ v   ++dl+       + se+    ++ ++++  +l+wn 
  EFC37702.1 158 LSTGINVKMQYWDASGKPTFNSLSRAYTRGVHVIGFCFDLNNEE----SfSEMKNRVEIYRNENFSNLKWNA 225
                 56779********************************9998655....336666666666677778888887 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   0.00013      0.21     144     203 ..     223     276 ..     189     280 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00013
        FTA2 144 sralgeedgkkrpiraIVKelellkeqeelevsqlpkllrdlkklhklgIvvrDlkeeny 203
                 ++a+ +e++ +  i+++ +     + + +++++q+++ +++l +++k+gI+++Dl+  +y
  EFC37702.1 223 WNANLKEENAHLLILGMKR-----DLERKVSIQQVKEYISELIQVKKEGILLKDLRI-QY 276
                 3444455555666666633.....57899**************************94.44 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00017      0.28      23      39 ..     115     131 ..     101     135 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00017
      AAA_29  23 gatlltGpsGsGKSTll 39 
                   t+l Gp GsGKS ++
  EFC37702.1 115 TKTVLLGPEGSGKSEIV 131
                 369***********887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       961  (0.0536003); expected 358.6 (0.02)
Passed bias filter:                      615  (0.034302); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 1936.41
//
Query:       EFC37703.1  [L=573]
Description: F-box-containing LRR repeat protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.1e-10   39.2  28.8      0.068   13.6   1.9    8.0  7  LRR_4       Leucine Rich repeats (2 copies)
    6.6e-06   25.8  19.2      0.055   13.6   0.0    8.3  9  LRR_6       Leucine Rich repeat
     0.0017   17.9   0.4     0.0077   15.9   0.4    2.1  1  LisH_TPL    LisH-like dimerisation domain
  ------ inclusion threshold ------
      0.011   15.7   0.7      0.022   14.6   0.7    1.5  1  F-box-like  F-box-like
      0.034   14.5   0.1       0.25   11.7   0.0    2.5  2  PRANC       PRANC domain
       0.08   12.7  17.6       0.29   10.9   0.0    5.9  6  LRR_8       Leucine rich repeat
       0.09   13.5   5.9        9.4    7.1   0.4    4.9  4  LRR_2       Leucine Rich Repeat
        1.8    9.4  21.0         15    6.6   0.0    7.6  8  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1     0.049   1.1e+02      16      32 ..      89     106 ..      87     113 .. 0.79
   2 ?   -1.0   0.0       1.2   2.7e+03      13      33 ..     124     145 ..     119     150 .. 0.64
   3 !    8.6   0.0    0.0012       2.7       1      38 [.     286     325 ..     286     329 .. 0.83
   4 !   12.8   0.3   5.4e-05      0.12       5      33 ..     315     345 ..     313     353 .. 0.85
   5 !   13.6   1.9     3e-05     0.068       2      33 ..     364     398 ..     363     432 .. 0.76
   6 !   13.2   2.9   4.1e-05     0.091       1      39 [.     456     498 ..     456     505 .. 0.89
   7 ?    0.2   0.2      0.51   1.1e+03       2      32 ..     512     547 ..     511     560 .. 0.65

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.049
                 -S-HHH.-TT--EEE-.- CS
       LRR_4  16 ipllek.lpnLkeLdLsg 32 
                 i+ l++ +++L+ L+Lsg
  EFC37703.1  89 IQVLRNrFKDLRFLNLSG 106
                 677788899999999987 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.2
                 --E-S-..HHH-TT--EEE-.-S CS
       LRR_4  13 ltdipl..leklpnLkeLdLsgN 33 
                 l+ +     e++++L ++ +  N
  EFC37703.1 124 LKVLRDsmREGCTKLNYFRM-AN 145
                 55555555567999999999.44 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0012
                 SS--EEE--SS.---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnN.qltdipl..leklpnLkeLdLsgNnlitd 38 
                 +n ++L+++n+ ++ + ++  ++k++  ++L+L g   i+d
  EFC37703.1 286 TNITSLSIANCvNIDSAGFeaISKMTGIHTLTLVGT-TIRD 325
                 799*******99999999966558*********887.5555 PP

  == domain 4  score: 12.8 bits;  conditional E-value: 5.4e-05
                 EEE--SS---E-S-HH..H-TT--EEE-.-S CS
       LRR_4   5 vLdLsnNqltdiplle..klpnLkeLdLsgN 33 
                 +L L ++ ++d +ll   klpnLk++dL+g+
  EFC37703.1 315 TLTLVGTTIRDADLLTisKLPNLKSIDLTGC 345
                 68889999******77758*********887 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 3e-05
                 S--EEE--SS---E-S-..HH.H-TT--EEE-..-S CS
       LRR_4   2 nLevLdLsnNqltdipl..le.klpnLkeLdL.sgN 33 
                 + e+L L +++ltd+ l  ++ kl+nLk Ld+ + N
  EFC37703.1 364 QMEELFLVDCNLTDWTLhiIKeKLKNLKFLDIsW-N 398
                 678999999999*9999763357*****999932.3 PP

  == domain 6  score: 13.2 bits;  conditional E-value: 4.1e-05
                 SS--EEE--.SS.---.E-S-.HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLs.nN.qlt.dipl.leklpnLkeLdLsgNnlitdl 39 
                 p+L++L+Ls  N q   +i+  l++ pnL +L Lsg++++td 
  EFC37703.1 456 PKLTKLNLSmRNyQCNeSIQAvLRNTPNLVSLQLSGCSRLTDD 498
                 79********999999999999999************999775 PP

  == domain 7  score: 0.2 bits;  conditional E-value: 0.51
                 S--EEE--SS.---E-S-....HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnN.qltdipl....leklpnLkeLdLsg 32 
                 +L++++L  +  ltd +l    +  + +L+ L L +
  EFC37703.1 512 KLKEVHLMRCsWLTDESLnklmPLCISSLENLFLQR 547
                 678888887746888666555533577799988833 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.68   1.5e+03       5      17 ..      99     111 ..      98     112 .. 0.81
   2 ?    3.5   0.0     0.042        95       3      24 .]     286     308 ..     286     308 .. 0.91
   3 ?   -3.0   0.1       4.9   1.1e+04       7      23 ..     315     331 ..     312     332 .. 0.76
   4 ?    2.9   0.0     0.065   1.4e+02       3      14 ..     335     346 ..     333     346 .. 0.88
   5 ?   -0.7   0.0      0.88     2e+03       2      17 ..     362     377 ..     361     377 .. 0.87
   6 !   13.6   0.0   2.4e-05     0.055       3      21 ..     388     407 ..     386     410 .. 0.88
   7 ?    1.0   0.1      0.26   5.7e+02       3      11 ..     456     464 ..     455     465 .. 0.88
   8 ?    5.0   0.1     0.013        30       3      18 ..     482     498 ..     480     501 .. 0.90
   9 !    5.4   0.0    0.0099        22       3      23 ..     511     532 ..     509     533 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.68
       LRR_6   5 LteLdLsgNdIgD 17 
                 L+ L+Lsg ++ D
  EFC37703.1  99 LRFLNLSGLQLYD 111
                 889****988755 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.042
       LRR_6   3 thLteLdLsgNd.IgDeGaeaLa 24 
                 t++t+L+++ +  I+ +G ea++
  EFC37703.1 286 TNITSLSIANCVnIDSAGFEAIS 308
                 689***************99986 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 4.9
       LRR_6   7 eLdLsgNdIgDeGaeaL 23 
                 +L L g  I D+ +  +
  EFC37703.1 315 TLTLVGTTIRDADLLTI 331
                 78888999999877655 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.065
       LRR_6   3 thLteLdLsgNd 14 
                 ++L++ dL+g++
  EFC37703.1 335 PNLKSIDLTGCK 346
                 89********96 PP

  == domain 5  score: -0.7 bits;  conditional E-value: 0.88
       LRR_6   2 nthLteLdLsgNdIgD 17 
                 ++ ++eL L +++++D
  EFC37703.1 362 CPQMEELFLVDCNLTD 377
                 7888999999****98 PP

  == domain 6  score: 13.6 bits;  conditional E-value: 2.4e-05
       LRR_6   3 thLteLdLsgNd.IgDeGae 21 
                  +L+ Ld+s+N  ++DeG+ 
  EFC37703.1 388 KNLKFLDISWNVdFTDEGMF 407
                 58****************96 PP

  == domain 7  score: 1.0 bits;  conditional E-value: 0.26
       LRR_6   3 thLteLdLs 11 
                 ++Lt+L+Ls
  EFC37703.1 456 PKLTKLNLS 464
                 68******9 PP

  == domain 8  score: 5.0 bits;  conditional E-value: 0.013
       LRR_6   3 thLteLdLsgNd.IgDe 18 
                 ++L +L+Lsg+  ++D+
  EFC37703.1 482 PNLVSLQLSGCSrLTDD 498
                 79*********999997 PP

  == domain 9  score: 5.4 bits;  conditional E-value: 0.0099
       LRR_6   3 thLteLdLsgNd.IgDeGaeaL 23 
                 ++L+e++L+ +  ++De + +L
  EFC37703.1 511 RKLKEVHLMRCSwLTDESLNKL 532
                 79***************98766 PP

>> LisH_TPL  LisH-like dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.4   3.4e-06    0.0077       2      24 ..      41      63 ..      41      65 .. 0.93

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 3.4e-06
    LisH_TPL  2 qDvVRLilQFLkEnsLHrtlqaL 24
                ++++ Li Q+L ++ L+ +l aL
  EFC37703.1 41 SEIIHLICQYLQSHDLFYSLFAL 63
                58*****************9988 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.7     1e-05     0.022       3      35 ..      38      71 ..      36      80 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1e-05
  F-box-like  3 rLPdEiLlqIFsyLppsdLlr.lalVCrrWrrva 35
                +LP Ei+  I +yL   dL   l + +r+W++  
  EFC37703.1 38 NLPSEIIHLICQYLQSHDLFYsLFALSRHWYESL 71
                8*************777755449********976 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00011      0.25      62      93 ..      28      57 ..      17      60 .. 0.80
   2 ?   -3.3   0.0       5.3   1.2e+04      50      68 ..      80      98 ..      78     104 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00011
       PRANC 62 lnnicskkslWnlLPiEIkykIleyLndkdLk 93
                ++ +   + ++ +LP EI + I++yL+++dL 
  EFC37703.1 28 MERYS--DHSLVNLPSEIIHLICQYLQSHDLF 57
                44552..47899******************96 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 5.3
       PRANC 50 krykliekaievlnnicsk 68
                +r k+ e ai+vl n +++
  EFC37703.1 80 RRCKNAEGAIQVLRNRFKD 98
                6889999999999998887 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.2      0.91     2e+03      49      58 ..      97     106 ..      93     109 .. 0.76
   2 ?   -0.4   0.0      0.43   9.7e+02      10      31 ..     120     142 ..     119     148 .. 0.79
   3 ?   10.9   0.0   0.00013      0.29       2      59 ..     287     345 ..     286     346 .. 0.89
   4 ?    4.7   0.2     0.012        26       2      37 ..     364     399 ..     363     422 .. 0.77
   5 ?    4.5   0.8     0.013        30      24      59 ..     455     492 ..     448     495 .. 0.86
   6 ?   -1.7   0.1       1.1   2.5e+03       2      10 ..     539     547 ..     524     556 .. 0.63

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.91
                 -S-.EEE--S CS
       LRR_8  49 psLrsLdLsg 58 
                 + Lr+L+Lsg
  EFC37703.1  97 KDLRFLNLSG 106
                 5688999887 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.43
                 TS-.-SEE-TTSSTT-TT--EEE CS
       LRR_8  10 nNr.ltslddeaFkglsnLkvLd 31 
                 +N  l++l+d++ +g+++L+++ 
  EFC37703.1 120 SNTiLKVLRDSMREGCTKLNYFR 142
                 55559999999999999999865 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 0.00013
                 T-SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 n tsL++ n   + s + ea +++++  +L L   +++  +  ++s Lp+L+s+dL+g+
  EFC37703.1 287 NITSLSIANCVnIDSAGFEAISKMTGIHTLTLVGTTIRDADLLTISKLPNLKSIDLTGC 345
                 678888877766999999999***********************************998 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.012
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNll 37 
                 + ++L L + +lt+   +  k  l+nLk Ld+s N  
  EFC37703.1 364 QMEELFLVDCNLTDWTLHIIKEkLKNLKFLDISWN-V 399
                 67889999999999999999988999999999988.4 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.013
                 -TT--EEE--.SS.---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  24 lsnLkvLdLs.nN.llttlspgafsgLpsLrsLdLsgN 59 
                 l++L+ L+Ls +N +++   + ++++ p+L sL Lsg+
  EFC37703.1 455 LPKLTKLNLSmRNyQCNESIQAVLRNTPNLVSLQLSGC 492
                 78999999997678888877899999999999999996 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 1.1
                 T-SEEE-TT CS
       LRR_8   2 nLtsLdLsn 10 
                 +L++L L++
  EFC37703.1 539 SLENLFLQR 547
                 344444444 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.57   1.3e+03      14      26 .]     351     363 ..     336     363 .. 0.76
   2 ?    4.2   0.1     0.034        76       1      21 [.     389     410 ..     389     410 .. 0.90
   3 ?    7.1   0.4    0.0042       9.4       1      25 [.     512     536 ..     512     537 .. 0.86
   4 ?   -0.9   0.0       1.4   3.1e+03       1      13 [.     539     551 ..     539     553 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.57
       LRR_2  14 dedslekLLSgCP 26 
                 +e++++ +L +CP
  EFC37703.1 351 SEETIVQFLTNCP 363
                 6789999*****9 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.034
       LRR_2   1 sLKtLhLds.VrfsdedslekL 21 
                 +LK L +++ V f+de +++ L
  EFC37703.1 389 NLKFLDISWnVDFTDEGMFNIL 410
                 69*******9999***999876 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0042
       LRR_2   1 sLKtLhLdsVrf.sdedslekLLSgC 25 
                 +LK  hL ++ + +de sl+kL + C
  EFC37703.1 512 KLKEVHLMRCSWlTDE-SLNKLMPLC 536
                 69*******9996777.*****8776 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 1.4
       LRR_2   1 sLKtLhLdsVrfs 13 
                 sL  L+L + +fs
  EFC37703.1 539 SLENLFLQRSKFS 551
                 7999****99995 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.2      0.68   1.5e+03       2      12 ..      99     109 ..      98     127 .. 0.70
   2 ?   -1.9   0.0       4.2   9.5e+03       6      13 ..     237     244 ..     235     260 .. 0.64
   3 ?   -0.8   0.0       1.8     4e+03       1      13 [.     287     299 ..     287     307 .. 0.77
   4 ?    6.6   0.0    0.0068        15       1      13 [.     336     348 ..     336     381 .. 0.85
   5 ?    5.6   0.0     0.015        33       1      11 [.     389     399 ..     389     420 .. 0.84
   6 ?   -0.1   0.0       1.1   2.5e+03       1      12 [.     457     471 ..     457     477 .. 0.71
   7 ?    4.6   0.4      0.03        66       1      22 [.     483     502 ..     483     503 .. 0.90
   8 ?   -1.6   0.2       3.3   7.3e+03       1      19 [.     512     528 ..     512     543 .. 0.57

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.68
       LRR_1   2 LrhLdLsnnpl 12 
                 Lr L+Ls+ +l
  EFC37703.1  99 LRFLNLSGLQL 109
                 999***88666 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 4.2
       LRR_1   6 dLsnnpll 13 
                 ++s++ ++
  EFC37703.1 237 YISRCKNI 244
                 78888863 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 1.8
       LRR_1   1 nLrhLdLsnnpll 13 
                 n ++L + n+ ++
  EFC37703.1 287 NITSLSIANCVNI 299
                 67899****9874 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0068
       LRR_1   1 nLrhLdLsnnpll 13 
                 nL+++dL+++ ++
  EFC37703.1 336 NLKSIDLTGCKNT 348
                 8*********983 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnp 11 
                 nL+ Ld+s+n 
  EFC37703.1 389 NLKFLDISWNV 399
                 8*********6 PP

  == domain 6  score: -0.1 bits;  conditional E-value: 1.1
       LRR_1   1 nLrhLdL...snnpl 12 
                 +L++L+L   +++++
  EFC37703.1 457 KLTKLNLsmrNYQCN 471
                 799****66655555 PP

  == domain 7  score: 4.6 bits;  conditional E-value: 0.03
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL +L Ls+++  +l+++sf+n
  EFC37703.1 483 NLVSLQLSGCS--RLTDDSFSN 502
                 899********..799999986 PP

  == domain 8  score: -1.6 bits;  conditional E-value: 3.3
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++ +L +++   l+++s
  EFC37703.1 512 KLKEVHLMRCS--WLTDES 528
                 68888886666..223333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       483  (0.0269396); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 3949.13
//
Query:       EFC37704.1  [L=381]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      2e-16   60.7   0.7      2e-16   60.7   0.7    4.7  2  CWC25       Pre-mRNA splicing factor


Domain annotation for each model (and alignments):
>> CWC25  Pre-mRNA splicing factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.7   0.7   1.1e-20     2e-16       3     102 .]      27     119 ..      25     119 .. 0.85
   2 ?  -38.8  54.0         1   1.8e+04      35      79 ..     129     172 ..     121     376 .. 0.81

  Alignments for each domain:
  == domain 1  score: 60.7 bits;  conditional E-value: 1.1e-20
       CWC25   3 erleWMYegpkeagaaeeeneeyllGKkrvdkllegkdkaekkkkakaskaesaaeqggaarlekvansardtanklreDPllaIkkqeqealkallkn 101
                 +++eWMY+++  ++ +ee+ eeyl+GKk+++kl++g d  +++ k       + +++++ a + +++++++++ + + +DP+++Ik++  +++k++l+n
  EFC37704.1  27 KQIEWMYNKDY-DKVNEESLEEYLVGKKSIEKLVQGGDLVDNDYKI------MLEQKKAGALFLHSHENRHHSGEAIIDDPMIKIKHESLMRMKMYLQN 118
                 789*****883.4469999*******************99999954......334444555555666899***************************** PP

       CWC25 102 P 102
                 P
  EFC37704.1 119 P 119
                 9 PP

  == domain 2  score: -38.8 bits;  conditional E-value: 1
       CWC25  35 llegkdkaekkkkakaskaesaaeqggaarlekvansardtank.l 79 
                   ++k++++kk+  k++k+e+++e++ +++ ++ +++++d+++k +
  EFC37704.1 129 RKKEKKEKKKKE--KKEKKEKKKEKKDKKEKKEKKEKKKDKKRKdY 172
                 322222222221..12222222233333333333344555554433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4344  (0.242289); expected 358.6 (0.02)
Passed bias filter:                      816  (0.0455129); expected 358.6 (0.02)
Passed Vit filter:                       509  (0.0283898); expected 17.9 (0.001)
Passed Fwd filter:                       139  (0.0077528); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 2.04u 0.40s 00:00:02.44 Elapsed: 00:00:00.62
# Mc/sec: 1845.06
//
Query:       EFC37705.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-16   60.2   0.1    3.3e-16   59.3   0.1    1.5  1  adh_short        short chain dehydrogenase
    1.9e-08   34.2   0.0    2.7e-08   33.6   0.0    1.2  1  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
    0.00011   22.2   0.1    0.00023   21.1   0.0    1.5  1  KR               KR domain
      0.007   16.1   0.0       0.11   12.2   0.0    2.5  3  Eno-Rase_NADH_b  NAD(P)H binding domain of trans-2-enoyl-CoA 
  ------ inclusion threshold ------
       0.16   11.4   0.1        0.5    9.8   0.0    1.8  2  Epimerase        NAD dependent epimerase/dehydratase family
       0.18   11.9   0.3        3.4    7.8   0.1    2.4  2  Ldh_1_N          lactate/malate dehydrogenase, NAD binding do


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.3   0.1   1.1e-19   3.3e-16       2     192 ..      79     297 ..      78     300 .. 0.75

  Alignments for each domain:
  == domain 1  score: 59.3 bits;  conditional E-value: 1.1e-19
                 EEEEESTTSHHHHHHHHHHH........HTT-EEEEEESCHHHHHHHHHHHHHT........TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE- CS
   adh_short   2 vvlvtGassGIGraiakela........keGakvvvvdrseekleevakelkee........gakalaiqvDvtdreevealvekavkklgkldvLvnN 84 
                  +l++G ssGIGr +a e+         ++  ++++v+r+ ++ e++++e+ +           ++ + q+Dvt++e+++++v+++       d++++N
  EFC37705.1  79 KILIVGSSSGIGRSLALEISskfatrknQKSLTLTLVGRNLAANEKLKEECSAIikeshpveDFEINVRQADVTNAERMKEIVNEM-----DYDCIIAN 172
                 69***********998877611112211334567779*****99***999999875433333344777777777777777777777.....67****** PP

                 --S........S--SSGGGCSHHHHH.HHHHHHTHHHHHHHHHHHHHHH......HCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHG CS
   adh_short  85 AGi........tgsgpfselseeewe.rvievNltgvflltravlpaml......kqssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakela 168
                 AG+        +++++f  l++ ++e ++ e+Nltg  +++  +++ ++      ++++ +++ +sS ++   ++++  Y ++K a++g++r+l+  l+
  EFC37705.1 173 AGVtifvmmgdKKPSEFTTLEKIQMEfKCWETNLTGCTNTAFPAIERLIqdadngNKKRRHVILTSSGTA--YFPEMGLYPTAKSALIGIARNLRAKLE 269
                 ***7777764444444444444442236699****************99988777777778999999887..999********************9997 PP

                 GGT....EEEEEEEESSBSSHHHHHHCT CS
   adh_short 169 ptg....irvnavaPGlvdTdmakelre 192
                 ++      rv++++PG v + m k+  +
  EFC37705.1 270 SSPkysnLRVSVLVPGWVHSSMSKAFPA 297
                 5433345***************987665 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.6   0.0   9.1e-12   2.7e-08      27     187 ..     122     300 ..      84     315 .. 0.73

  Alignments for each domain:
  == domain 1  score: 33.6 bits;  conditional E-value: 9.1e-12
                   SGGHHHHHHHHHHHTT..SEE....EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EG....CSS-GGGH-HHHHH...HHHHHHTHHHHHHH CS
  adh_short_C2  27 neeakkrveelaeelg..aev....lecDVtdeeqvealveevvekfgklDilvnnagiapk....lkgpfletsreefd...raldvnlyslflla 110
                   ne++k+++ ++ +e    +++     ++DVt+ e ++++v+e+       D+++ nag++       k+p + t+ e+++   +  ++nl++++++a
    EFC37705.1 122 NEKLKEECSAIIKESHpvEDFeinvRQADVTNAERMKEIVNEMD-----YDCIIANAGVTIFvmmgDKKPSEFTTLEKIQmefKCWETNLTGCTNTA 213
                   34445555555555443322233448999999999999999965.....699999999998887765666666777777733457789******999 PP

                   HHHHH.HCTSC......CEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHHHGG....GTEEEEEEEE--BHCTGGGGSTTHHH CS
  adh_short_C2 111 kaalp.lmkeg......gsivnlssvgaervvpnynaygaaKaalealtrylAvelgp....kgiRvNavspgpikTlaasgikgfde 187
                     a++ l+++        + v l+s  ++ ++p+   y +aK al++++r+l ++l +     + Rv +  pg+++  ++++++ ++ 
    EFC37705.1 214 FPAIErLIQDAdngnkkRRHVILTSS-GTAYFPEMGLYPTAKSALIGIARNLRAKLESspkySNLRVSVLVPGWVHSSMSKAFPAKEM 300
                   99888777765666676678888888.679**********************999987556679****************99986554 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   7.6e-08   0.00023       4     106 ..      81     190 ..      79     201 .. 0.71

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 7.6e-08
                 EEETTTSHHHHHHHHHHHH.......HHS-EEEEE-SS..--HHHHH....HHHHHHHT.T-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE--- CS
          KR   4 litGGlGgLGlelarwlae.......kgarhlvllsRsaaadedska....liaeleal.gaevevvaaDvsdkdavealleeikaeeppikGvihaAg 90 
                 li+G   g+G++la  + +       +   +l l++R+ aa+e+ k+     i+e +   + e++v++aDv++++ ++++++e++ +      +i  Ag
  EFC37705.1  81 LIVGSSSGIGRSLALEISSkfatrknQKSLTLTLVGRNLAANEKLKEecsaIIKESHPVeDFEINVRQADVTNAERMKEIVNEMDYDC-----IIANAG 174
                 9*************99998343332223346999****877777666122144444443466**********************9655.....666666 PP

                 ------TTT--HHHHH CS
          KR  91 vlrdklleemtaedle 106
                 v+   ++ +++ ++++
  EFC37705.1 175 VTIFVMMGDKKPSEFT 190
                 6666666666665555 PP

>> Eno-Rase_NADH_b  NAD(P)H binding domain of trans-2-enoyl-CoA reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   3.8e-05      0.11      34      64 ..      73     103 ..      62     112 .. 0.80
   2 ?    0.3   0.0       0.2   5.8e+02       8      49 ..     198     239 ..     192     243 .. 0.63
   3 ?   -4.0   0.0       4.5   1.4e+04      47      62 ..     326     341 ..     323     345 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 3.8e-05
                      -----.-SEEEEESTSSHHH..HHHHHHHHHSS CS
  Eno-Rase_NADH_b  34 kkiekgpkkvLviGaStGYG..LAsriaaafga 64 
                      ++++    k+L++G+S+G G  LA  i+++f++
       EFC37705.1  73 EEYN--YEKILIVGSSSGIGrsLALEISSKFAT 103
                      4444..689***********8899999999875 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.2
                      TTEESS--HHHHHHHHHHHHHHHHHS-----.-SEEEEESTS CS
  Eno-Rase_NADH_b   8 gficltahPaGcaknveeqieyvksqkkiekgpkkvLviGaS 49 
                      +f c +++ +Gc+++    ie   ++++  ++ ++  ++ +S
       EFC37705.1 198 EFKCWETNLTGCTNTAFPAIERLIQDADNGNKKRRHVILTSS 239
                      56688899999*999999998875444444333444444333 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 4.5
                      STSSHHHHHHHHHHHH CS
  Eno-Rase_NADH_b  47 GaStGYGLAsriaaaf 62 
                        S  +GL  r+ ++f
       EFC37705.1 326 DISGVWGLIMRVFLKF 341
                      5577899999999887 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.34     1e+03      96     122 ..      66      92 ..      59     110 .. 0.75
   2 ?    9.8   0.0   0.00017       0.5      14      88 ..     119     190 ..      80     204 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.34
                 HHHHHHHHHHTCTEEEEEEEGGGGTSC CS
   Epimerase  96 lnlleaarkagvkrllflsSsevYGkd 122
                  +l++ + +++ +++l ++Ss+  G++
  EFC37705.1  66 KDLFKSSEEYNYEKILIVGSSSGIGRS 92 
                 567788888888888888888777765 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00017
                 HHHHHHHCTSEEEEEES-STTTTCHHCHHC...............EEEE--TT-HHHHHHHHHHHT-SEEEE--S.---HHHHHHSHHHHH CS
   Epimerase  14 lvkallekgyevigldrlssasntarledl...............elveldltdrsalerlfkeeqpdavihlAa.vggvaassedpadfi 88 
                 l+                    n++++e+                ++ ++d+t++++++++++e + d++i  A+    v+   ++p++f 
  EFC37705.1 119 LA-------------------ANEKLKEECsaiikeshpvedfeiNVRQADVTNAERMKEIVNEMDYDCIIANAGvTIFVMMGDKKPSEFT 190
                 22...................22222222245556666666666699*************************9998888888888888775 PP

>> Ldh_1_N  lactate/malate dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.1    0.0011       3.4       2      29 ..      79     112 ..      78     176 .. 0.79
   2 ?    1.9   0.0     0.071   2.1e+02      10      35 ..     303     328 ..     301     335 .. 0.93

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0011
                 EEEEETTTSHHHHHHHHHHHHTTSSSE......E CS
     Ldh_1_N   2 kvavvGaaGgiGqslalllankklade......l 29 
                 k+ +vG++ giG slal + +k  +++      l
  EFC37705.1  79 KILIVGSSSGIGRSLALEISSKFATRKnqksltL 112
                 9******************998444444666443 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.071
                 SHHHHHHHHHHHHTTSSSEEEEE-SS CS
     Ldh_1_N  10 GgiGqslalllankkladelaLlDia 35 
                 G+i+++la +l  +++ ++++++Di 
  EFC37705.1 303 GMISSELAAKLTWSGIERDFEIIDIS 328
                 99**********************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 2061.43
//
Query:       EFC37706.1  [L=576]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-18   64.5  34.8     0.0017   18.2   0.0   10.7 11  LRR_6     Leucine Rich repeat
    7.2e-08   32.1   0.1    3.7e-07   29.9   0.0    2.2  2  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom
    7.7e-06   25.8  19.9        3.4    8.6   0.0    8.9  8  LRR_1     Leucine Rich Repeat
    9.3e-06   25.9  35.9      0.032   14.7   3.8    8.0  8  LRR_4     Leucine Rich repeats (2 copies)
     0.0019   18.0   0.4      0.038   13.8   0.1    2.5  2  RRM_Rrp7  Rrp7 RRM-like N-terminal domain
  ------ inclusion threshold ------
       0.49    9.9  12.8       0.24   10.9   1.9    3.3  3  LRR_9     Leucine-rich repeat
       0.67    9.8  36.8        2.7    7.8   1.9    9.0  8  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.0   6.8e-07    0.0017       3      24 .]       7      28 ..       7      28 .. 0.96
   2 ?   -1.8   0.0       1.8   4.6e+03       2      24 .]     119     141 ..     118     141 .. 0.82
   3 !    7.4   0.7    0.0019         5       2      15 ..     145     158 ..     144     160 .. 0.87
   4 ?    4.3   1.1      0.02        51       4      17 ..     198     211 ..     195     212 .. 0.91
   5 !   10.8   0.3   0.00017      0.43       2      16 ..     230     244 ..     230     246 .. 0.93
   6 !   11.9   0.0   7.3e-05      0.19       2      24 .]     260     282 ..     259     282 .. 0.92
   7 !   13.0   0.5   3.3e-05     0.084       2      23 ..     288     309 ..     287     310 .. 0.86
   8 ?    2.0   0.0      0.11   2.7e+02       1      13 [.     315     327 ..     315     334 .. 0.90
   9 ?    2.3   0.1     0.088   2.2e+02       1      13 [.     343     355 ..     343     356 .. 0.91
  10 !   10.4   0.3   0.00022      0.55       1      18 [.     371     388 ..     371     394 .. 0.89
  11 ?   -1.4   0.0       1.3   3.4e+03       6      15 ..     407     416 ..     406     417 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.8e-07
       LRR_6  3 thLteLdLsgNdIgDeGaeaLa 24
                +hL+eLdLs ++I   Gae++a
  EFC37706.1  7 PHLRELDLSRCGIRQNGAECIA 28
                6*******************98 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.8
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                 + +L+  d++  ++ D  + a+a
  EFC37706.1 119 SKSLKDIDMAETKFKDISLFAFA 141
                 6789999*999999998887776 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0019
       LRR_6   2 nthLteLdLsgNdI 15 
                 n  L++L+Ls NdI
  EFC37706.1 145 NYVLETLNLSNNDI 158
                 5569*********9 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.02
       LRR_6   4 hLteLdLsgNdIgD 17 
                 hL++L Ls N++++
  EFC37706.1 198 HLQKLTLSKNNLTN 211
                 9**********996 PP

  == domain 5  score: 10.8 bits;  conditional E-value: 0.00017
       LRR_6   2 nthLteLdLsgNdIg 16 
                 +t+L +LdLsg++I+
  EFC37706.1 230 CTNLNYLDLSGCKID 244
                 79***********97 PP

  == domain 6  score: 11.9 bits;  conditional E-value: 7.3e-05
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                 n  L++L L+ N+Ig  G+  La
  EFC37706.1 260 NLPLKTLKLNNNEIGKTGLRPLA 282
                 667****************9997 PP

  == domain 7  score: 13.0 bits;  conditional E-value: 3.3e-05
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                 nt+++ LdLsgNd+g  G  +L
  EFC37706.1 288 NTTIEDLDLSGNDLGVTGSVSL 309
                 9**************9886655 PP

  == domain 8  score: 2.0 bits;  conditional E-value: 0.11
       LRR_6   1 snthLteLdLsgN 13 
                 +n+++++L++ ++
  EFC37706.1 315 NNSSIKKLNIFSC 327
                 79********998 PP

  == domain 9  score: 2.3 bits;  conditional E-value: 0.088
       LRR_6   1 snthLteLdLsgN 13 
                 +nt++t Ld+  N
  EFC37706.1 343 QNTSITDLDIGLN 355
                 69********998 PP

  == domain 10  score: 10.4 bits;  conditional E-value: 0.00022
       LRR_6   1 snthLteLdLsgNdIgDe 18 
                 +nt+L+ L L+ N+++D+
  EFC37706.1 371 QNTTLKRLGLKLNHLSDK 388
                 69**************97 PP

  == domain 11  score: -1.4 bits;  conditional E-value: 1.3
       LRR_6   6 teLdLsgNdI 15 
                 ++L LsgN +
  EFC37706.1 407 QYLALSGNSL 416
                 7899****76 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.95   2.4e+03      18      33 ..     324     339 ..     311     347 .. 0.73
   2 !   29.9   0.0   1.4e-10   3.7e-07       1      57 [.     456     518 ..     456     527 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.95
                 HHHTTSCEEEEEEEEE CS
       RRM_1  18 lFskfGpiksiklvrd 33 
                 +Fs f +i+ i+++++
  EFC37706.1 324 IFSCFVQIEGIDIISK 339
                 6777778888888877 PP

  == domain 2  score: 29.9 bits;  conditional E-value: 1.4e-10
                 EEEESETTTSSHHHHHHHHHT..TSCEEEEEEEEE....TTTSEEEEEEEEESSHHHHHHHHH CS
       RRM_1   1 lfVgnLppdvteeeLkelFsk..fGpiksiklvrd....etgkskgfafVeFeskedAekAle 57 
                 ++++ Lp+++t +++k++F +  +G i ++ + +     ++ + +++afVeF+ +++ + A++
  EFC37706.1 456 IYLSPLPNSITIQDIKKFFYQhkCGAILNVYIHKHktpnKKTRLNKYAFVEFAHPDSLQLAIR 518
                 79999**************9888***********99988888999****************98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0    0.0013       3.4       1      20 [.       8      27 ..       8      31 .. 0.86
   2 !    6.6   0.4    0.0057        15       2      13 ..     148     168 ..     147     178 .. 0.69
   3 ?    2.9   0.8     0.097   2.5e+02       1      17 [.     198     214 ..     198     219 .. 0.81
   4 ?    5.3   0.0     0.016        41       1      12 [.     232     243 ..     232     255 .. 0.86
   5 ?    2.1   0.0      0.17   4.5e+02       2      13 ..     263     274 ..     262     286 .. 0.79
   6 ?    3.0   0.0      0.09   2.3e+02       3      16 ..     292     305 ..     290     317 .. 0.77
   7 ?    1.4   0.0       0.3   7.7e+02       2      21 ..     319     342 ..     318     344 .. 0.76
   8 ?    0.1   0.0      0.81   2.1e+03       3      13 ..     407     418 ..     405     432 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0013
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +Lr+LdLs++ + + +++++
  EFC37706.1  8 HLRELDLSRCGIRQNGAECI 27
                69*********988887776 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0057
       LRR_1   2 LrhLdLsnnpl.........l 13 
                 L++L+Lsnn +          
  EFC37706.1 148 LETLNLSNNDIklsevyqlyC 168
                 9********985555555554 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.097
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L Ls n+l++l+ 
  EFC37706.1 198 HLQKLTLSKNNLTNLLQ 214
                 69**********87765 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.016
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL +LdLs++ +
  EFC37706.1 232 NLNYLDLSGCKI 243
                 899*******98 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.17
       LRR_1   2 LrhLdLsnnpll 13 
                 L++L L+nn ++
  EFC37706.1 263 LKTLKLNNNEIG 274
                 9********983 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.09
       LRR_1   3 rhLdLsnnpllglp 16 
                 + LdLs+n l+  +
  EFC37706.1 292 EDLDLSGNDLGVTG 305
                 669******95544 PP

  == domain 7  score: 1.4 bits;  conditional E-value: 0.3
       LRR_1   2 LrhLdLsnnpl....lglppnsfq 21 
                  ++L++ +++     +++++ ++q
  EFC37706.1 319 IKKLNIFSCFVqiegIDIISKALQ 342
                 689*******65555788887776 PP

  == domain 8  score: 0.1 bits;  conditional E-value: 0.81
       LRR_1   3 rhLdLsnnpl.l 13 
                 ++L Ls+n+l +
  EFC37706.1 407 QYLALSGNSLsI 418
                 678899999842 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.021        54      23      33 ..       7      17 ..       3      25 .. 0.62
   2 ?    2.1   0.0      0.11   2.9e+02       3      40 ..      94     136 ..      85     139 .. 0.61
   3 !   12.1   0.6     8e-05       0.2       1      41 [.     120     159 ..     120     167 .. 0.81
   4 !    7.4   1.3    0.0025       6.4       3      21 ..     148     165 ..     146     186 .. 0.69
   5 ?    4.9   3.6     0.014        37      21      39 ..     195     212 ..     168     219 .. 0.71
   6 !   14.7   3.8   1.3e-05     0.032       2      37 ..     198     244 ..     197     247 .. 0.81
   7 !    9.1   1.5   0.00073       1.9       3      39 ..     263     301 ..     263     310 .. 0.83
   8 ?   -0.7   6.0      0.84   2.2e+03       4      30 ..     292     324 ..     289     423 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.021
                TT--EEE-.-S CS
       LRR_4 23 pnLkeLdLsgN 33
                p+L+eLdLs++
  EFC37706.1  7 PHLRELDLSRC 17
                55555555554 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.11
                 --EEE--S.S-...--E-S-HH...H-TT--EEE-.-S-----GG CS
       LRR_4   3 LevLdLsn.Nq...ltdiplle...klpnLkeLdLsgNnlitdld 40 
                 L++++L   N    lt  + ++   k ++Lk +d+ +  + +d++
  EFC37706.1  94 LKKINLWKaNGfhiLT-QEVFNrigKSKSLKDIDMAET-KFKDIS 136
                 5555555312244333.334445546999999999666.777775 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 8e-05
                 SS--EEE--SS---E-S-HH.H-TT...--EEE-.-S-----GGG CS
       LRR_4   1 pnLevLdLsnNqltdiplle.klpn...LkeLdLsgNnlitdlde 41 
                 ++L+ +d + ++ +di+l++  l++   L++L+Ls+N    d+ +
  EFC37706.1 120 KSLKDIDMAETKFKDISLFAfALKDnyvLETLNLSNN----DI-K 159
                 579999999999******6643888899******888....76.3 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.0025
                 --EEE--SS---E-S-HHH CS
       LRR_4   3 LevLdLsnNqltdipllek 21 
                 Le+L+LsnN ++ ++  ++
  EFC37706.1 148 LETLNLSNNDIK-LSEVYQ 165
                 899999999998.656444 PP

  == domain 5  score: 4.9 bits;  conditional E-value: 0.014
                 H-TT--EEE-.-S-----G CS
       LRR_4  21 klpnLkeLdLsgNnlitdl 39 
                 kl +L++L+Ls N ++t+l
  EFC37706.1 195 KLVHLQKLTLSKN-NLTNL 212
                 5777777777777.33343 PP

  == domain 6  score: 14.7 bits;  conditional E-value: 1.3e-05
                 S--EEE--SS---E-S-HH...........H.-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdiplle...........k.lpnLkeLdLsgNnlit 37 
                 +L++L Ls N+lt +   +           k ++nL +LdLsg+ +i+
  EFC37706.1 198 HLQKLTLSKNNLTNLLQSNikeaisigqimKmCTNLNYLDLSGC-KID 244
                 7*******99999755533567788899**66************.554 PP

  == domain 7  score: 9.1 bits;  conditional E-value: 0.00073
                 --EEE--SS---E-S-..HH...H.-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdipl..le...k.lpnLkeLdLsgNnlitdl 39 
                 L++L L+nN + + +l  l+   k ++  + LdLsgN    dl
  EFC37706.1 263 LKTLKLNNNEIGKTGLrpLAsimKlNTTIEDLDLSGN----DL 301
                 89**********9888766666666666999******....77 PP

  == domain 8  score: -0.7 bits;  conditional E-value: 0.84
                 -EEE--SS---E-S-..HH....H-TT--EEE- CS
       LRR_4   4 evLdLsnNqltdipl..le....klpnLkeLdL 30 
                 e LdLs+N l   ++  l+    ++ + k+L++
  EFC37706.1 292 EDLDLSGNDLGVTGSvsLAeiitNNSSIKKLNI 324
                 567777777553333332234445666666665 PP

>> RRM_Rrp7  Rrp7 RRM-like N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.09   2.3e+02      50      99 ..      46      96 ..      35     106 .. 0.82
   2 !   13.8   0.1   1.5e-05     0.038      34      82 ..     447     494 ..     438     539 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.09
    RRM_Rrp7 50 Piettletlkkffqkvalgatie.svvsslltdeqedvsidltkltsdlel 99
                P e  l t+ k ++  ++ a i+ s++ss++ + ++++ ++l  l++ l++
  EFC37706.1 46 PSEQGLYTILKHLGYSSCIAEIDfSMTSSIVANGNSESMVKLLDLSTTLKK 96
                5666777888888999999999956778999999************99987 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 1.5e-05
    RRM_Rrp7  34 knndeessrslFlvNlPiettletlkkffqkvalgatiesvvsslltde 82 
                 k++++ ++r+++l  lP   t++ +kkff ++++ga+++ ++   +t  
  EFC37706.1 447 KDTEK-QNRTIYLSPLPNSITIQDIKKFFYQHKCGAILNVYIHKHKTPN 494
                 44454.59******************************99965544433 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   1.9   9.3e-05      0.24      44     105 ..     148     214 ..     121     234 .. 0.77
   2 ?    5.1   0.9    0.0057        15      24     119 ..     236     338 ..     217     352 .. 0.66
   3 ?   -1.5   0.1       0.6   1.5e+03     114     161 ..     405     452 ..     364     465 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 9.3e-05
       LRR_9  44 fdtidlsdndirkldgfPllkrlktlllnn.nrivriaegleevlP....nleelvltnnelqelad 105
                 ++t++ls+ndi+  + + l  rl  l ++n n+ +   +g + ++P    +l++l l++n+l++l +
  EFC37706.1 148 LETLNLSNNDIKLSEVYQLYCRLLLLHFENaNKTREFLDGPNAAVPpklvHLQKLTLSKNNLTNLLQ 214
                 489***********************986538888888888877764444699**********9965 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0057
       LRR_9  24 ldlrgyki..pvienlGatld.qfd....tidlsdndirkldgfPllkrlktlllnnnrivriaegleev.lPnleelvltnnelqeladldPlaslkk 114
                 ldl g ki  + +e + a+ld +f+    t++l++n+i k    Pl   +  l    + +   +++l+ +   +l e++ +n+++++l+ +  +++++ 
  EFC37706.1 236 LDLSGCKIdkTHMEGIAAALDpKFNlplkTLKLNNNEIGKTGLRPLAS-IMKLNTTIEDLDLSGNDLGVTgSVSLAEIITNNSSIKKLNIFSCFVQIEG 333
                 777787773335778888888534333338888888888876555544.44455555555666677765524478888888888888888888888887 PP

       LRR_9 115 lells 119
                 ++++s
  EFC37706.1 334 IDIIS 338
                 77776 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.6
       LRR_9 114 klellsllknpvtnkkeyrlyviyklkqlrlldfrkvklkereeaekl 161
                  +++l+l  n+++  +     ++    + r+++f   kl e +++ek 
  EFC37706.1 405 AIQYLALSGNSLSISTSSNISIVLNSVKDRVIEFDLTKLVEVKDTEKQ 452
                 467777777777777777766666666667777777777776666654 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.044   1.1e+02      48      59 ..       6      17 ..       4      20 .. 0.62
   2 ?    7.8   1.9     0.001       2.7       2      61 .]      93     158 ..      92     158 .. 0.77
   3 ?    4.0   4.6     0.017        43       2      16 ..     198     212 ..     194     243 .. 0.66
   4 ?    2.5   2.5     0.047   1.2e+02      27      61 .]     263     301 ..     258     301 .. 0.62
   5 ?   -2.0   0.0       1.3   3.2e+03      19      35 ..     339     355 ..     334     359 .. 0.62
   6 ?   -0.4   0.1       0.4     1e+03      22      38 ..     370     386 ..     366     393 .. 0.74
   7 ?    1.2   0.0      0.13   3.3e+02      27      38 ..     406     417 ..     403     422 .. 0.69
   8 ?   -3.1   0.0       2.8   7.2e+03      35      50 ..     494     509 ..     494     515 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.044
                --S-.EEE--SS CS
       LRR_8 48 LpsLrsLdLsgN 59
                 p+Lr+LdLs++
  EFC37706.1  6 VPHLRELDLSRC 17
                466677777665 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.001
                 T-SEEE-TTS-.-SEE-TTSSTT...-TT--EEE--SS---GGGGGGGT..T--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNr.ltslddeaFkg...lsnLkvLdLsnNllttlspgafs..gLpsLrsLdLsgNrL 61 
                 +L++++L++ + ++ l +e+F++    ++Lk +d+ + + + +s  af+  +   L+ L+Ls+N++
  EFC37706.1  93 TLKKINLWKANgFHILTQEVFNRigkSKSLKDIDMAETKFKDISLFAFAlkDNYVLETLNLSNNDI 158
                 688888988888999999999864446899999999999999887776522666799999999987 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.017
                 T-SEEE-TTS--SEE CS
       LRR_8   2 nLtsLdLsnNrltsl 16 
                 +L++L Ls+N+lt+l
  EFC37706.1 198 HLQKLTLSKNNLTNL 212
                 455555555555554 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.047
                 --EEE--SS---GGGGGGGTT--S-.....EEE--SS-- CS
       LRR_8  27 LkvLdLsnNllttlspgafsgLpsL....rsLdLsgNrL 61 
                 Lk+L+L+nN++     + +++  +L    + LdLsgN+L
  EFC37706.1 263 LKTLKLNNNEIGKTGLRPLASIMKLnttiEDLDLSGNDL 301
                 889999999887765554444444322225677777776 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 1.3
                 TSSTT-TT--EEE--SS CS
       LRR_8  19 eaFkglsnLkvLdLsnN 35 
                 +a +++++ + Ld++ N
  EFC37706.1 339 KALQQNTSITDLDIGLN 355
                 45555666666666666 PP

  == domain 6  score: -0.4 bits;  conditional E-value: 0.4
                 TT-TT--EEE--SS--- CS
       LRR_8  22 kglsnLkvLdLsnNllt 38 
                 k+++ Lk L L+ N l+
  EFC37706.1 370 KQNTTLKRLGLKLNHLS 386
                 66677888888888776 PP

  == domain 7  score: 1.2 bits;  conditional E-value: 0.13
                 --EEE--SS--- CS
       LRR_8  27 LkvLdLsnNllt 38 
                  ++L Ls N+l+
  EFC37706.1 406 IQYLALSGNSLS 417
                 567777777765 PP

  == domain 8  score: -3.1 bits;  conditional E-value: 2.8
                 S---GGGGGGGTT--S CS
       LRR_8  35 NllttlspgafsgLps 50 
                 N+ t+l++ af+ +++
  EFC37706.1 494 NKKTRLNKYAFVEFAH 509
                 7788888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       587  (0.0327403); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 3511.61
//
Query:       EFC37707.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.1e-27   96.2  21.6    2.8e-27   95.8  21.6    1.1  1  TPT            Triose-phosphate Transporter family
    8.9e-06   25.9  33.0    0.00042   20.5  11.6    3.0  2  EamA           EamA-like transporter family
    7.8e-05   22.0  20.0    7.8e-05   22.0  20.0    2.0  2  UAA            UAA transporter family


Domain annotation for each model (and alignments):
>> TPT  Triose-phosphate Transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.8  21.6   4.6e-31   2.8e-27       3     289 ..      19     320 ..      17     321 .. 0.85

  Alignments for each domain:
  == domain 1  score: 95.8 bits;  conditional E-value: 4.6e-31
         TPT   3 lgllfllWYllnvvfnilnKkilnvf..pyPltvsavqllvgsvlilvlwal...glkkrpkisse.flkailplalvktlghvlavvslskvaVSfth 95 
                 + +++++W +l +   ++nK +++ +  +yP+++s+v++++ +++ +++w     ++k+  + + + +   i+  +l+ +l   ++++s+++v+   ++
  EFC37707.1  19 IFFYCIVWLILVIGLSFMNKAVFKWTefKYPVLLSTVHMIINWLMGSFVWGRmngKIKEEEEKKGHdLRHLIMYFSLLFVLNIAFGNMSVKAVNLLLSQ 117
                 789********************97655**********************8744345544444444577889999************************ PP

         TPT  96 tvKasePiFtvilsrll.lgeklsllvylsLlpivgGvala.........svtEls.FnligfisAlisnltfslrnifsKkllkklkdldalnlfaii 183
                 + ++s+PiF  i s +l +g ++s+ v+l++lpi+ Gv l+         s tE +  n+ ++   li n++ +l+  +  k l+++k ++ + l++ +
  EFC37707.1 118 VFRSSMPIFIMICSVVLgVGSRPSTRVILTVLPIIIGVYLTckkddskvsSNTEEDlLNIKSLAILLIGNIMCALKTTLTNKYLNQYK-FHPIYLLSKL 215
                 **************998689******************98622222222255555437999*************************87.********** PP

         TPT 184 tilslllllPvallveg.vlktpsllkstkvslkevllllllsgvlfhlynqvaymvLervspvthsvantvKrvvvIvlsvlvfknpvsllnaiGtav 281
                 ++ s + ++ +a ++ +    + ++l+    ++ +++  ++  g++ +l n   + + + +sp+t  +   + +v+ + ls +vf ++++  n+iG ++
  EFC37707.1 216 SMWSSFGMFAFAAVTGEvSDLFNNNLHV--LYNVKTVGFVISTGFVAFLLNYFNFLANSSTSPLTMGICGLLHQVLTVYLSTIVFDTSLNQTNVIGICL 312
                 **99988887766555513333333333..35677888899********************************************************** PP

         TPT 282 aivGvflY 289
                 a++G  lY
  EFC37707.1 313 AMIGSALY 320
                 *******9 PP

>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4  13.7   0.00038       2.3      29     135 ..      48     158 ..      19     159 .. 0.75
   2 !   20.5  11.6   7.1e-08   0.00042       6     135 ..     182     320 ..     177     322 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00038
        EamA  29 spltltfvrfliagillliiallkegkl...aklslkdwllllllgllgtvlafllffyalkktsasnaslitslePvftlilsvlll.gekltlkqll 123
                  p+ l++v ++i  ++ +++     gk+   ++ +  d+  l+ +  l +vl   + ++++k ++     ++ s +P+f++i+sv+l  g +++ + +l
  EFC37707.1  48 YPVLLSTVHMIINWLMGSFVWGRMNGKIkeeEEKKGHDLRHLIMYFSLLFVLNIAFGNMSVKAVNLLLSQVFRSSMPIFIMICSVVLGvGSRPSTRVIL 146
                 555666666655555544443333333356667777788888767778999999999*****************************988********** PP

        EamA 124 givlillGvlli 135
                  ++ i++Gv+l+
  EFC37707.1 147 TVLPIIIGVYLT 158
                 **********96 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 7.1e-08
        EamA   6 lallaalfwaiyfvlskillrkv..spltltfvrfliagillliiallkegkl........aklslkdwllllllgllgtvlafllffyalkktsasna 94 
                 ++l++ ++ a+ ++l+ + l+++  +p+ l+   ++ +++ ++++a+++++            +++k + +++ +g+++++l  ++ f a ++ts+ + 
  EFC37707.1 182 ILLIGNIMCALKTTLTNKYLNQYkfHPIYLLSKLSMWSSFGMFAFAAVTGEVSdlfnnnlhVLYNVKTVGFVISTGFVAFLLN-YFNFLANSSTSPLTM 279
                 57888999999999998887777668998888666666777766666655555456655567778888999999998888887.5999999******** PP

        EamA  95 slitslePvftlilsvlllgekltlkqllgivlillGvlli 135
                 +++ +l  v+t+ ls +++  +l+ + ++gi+l+++G +l 
  EFC37707.1 280 GICGLLHQVLTVYLSTIVFDTSLNQTNVIGICLAMIGSALY 320
                 *************************************9986 PP

>> UAA  UAA transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   1.2     0.011        63      65     113 ..      22      70 ..      18      77 .. 0.85
   2 !   22.0  20.0   1.3e-08   7.8e-05      67     300 ..      92     322 ..      78     324 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.011
         UAA  65 Yvil.valffitsvlnnealkydisvPvhiifrssklipvmilGililgk 113
                 Y+i+  +l ++ s +n+ ++k+   +   +++    +i++ ++G ++ g+
  EFC37707.1  22 YCIVwLILVIGLSFMNKAVFKW-TEFKYPVLLSTVHMIINWLMGSFVWGR 70 
                 555414667889**********.999999****************99887 PP

  == domain 2  score: 22.0 bits;  conditional E-value: 1.3e-08
         UAA  67 ilvalffitsvlnnealkydisvPvhiifrssklipvmilGili.lgkrYsllqylsvllltlGviiftllsakdkkedskeslnkfllGiallvlall 164
                   ++lf++  +  n ++k  +++ +  +frss  i  mi+++++ +g r s + +l+vl + +Gv +    ++ +k++ ++e+   ++  +a+l++  +
  EFC37707.1  92 YFSLLFVLNIAFGNMSVKA-VNLLLSQVFRSSMPIFIMICSVVLgVGSRPSTRVILTVLPIIIGVYLTCK-KDDSKVSSNTEEDLLNIKSLAILLIGNI 188
                 4567888889999999999.*********************9883579*****************98777.5555567777777778999999999999 PP

         UAA 165 ldavlglvqeklykkygkhskealfyshllslplflllqgellsavkflsesedvallslpsklfylllnvltqyvcikgVlilisefgaltvtlvltl 263
                 + a+  ++++k  ++y+ h    l    ++s   ++    ++  +v +l++++ + l ++ +  f ++    ++++   + ++ +s+++ lt+ +   l
  EFC37707.1 189 MCALKTTLTNKYLNQYKFHPIYLLSKLSMWSSFGMF-AFAAVTGEVSDLFNNNLHVLYNVKTVGF-VISTGFVAFLLNYFNFLANSSTSPLTMGICGLL 285
                 ******************998888888888876655.4556777777777777777645544433.33334444444445555666777799******* PP

         UAA 264 RKfvslllSillFknpltlqhlvgtllVflglllysy 300
                  +++++ lS ++F+  l  + ++g  l ++g +ly+ 
  EFC37707.1 286 HQVLTVYLSTIVFDTSLNQTNVIGICLAMIGSALYTF 322
                 **********************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1019  (0.0568353); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 2162.91
//
Query:       EFC37708.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       508  (0.028334); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2199.50
//
Query:       EFC37709.1  [L=1353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.3e-09   35.1  22.1    9.3e-09   35.1  22.1    3.2  2  Frag1          Frag1/DRAM/Sfk1 family
    1.8e-06   28.7   0.9    1.8e-06   28.7   0.9    2.9  3  zf-PARP        Poly(ADP-ribose) polymerase and DNA-Ligase Zn-
    3.1e-05   23.9   0.1    0.00034   20.5   0.1    2.6  1  Abhydrolase_3  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.031   14.1   0.0      0.095   12.5   0.0    1.8  1  Abhydrolase_2  Phospholipase/Carboxylesterase
       0.13   11.7   0.0       0.27   10.7   0.0    1.4  1  Peptidase_S9   Prolyl oligopeptidase family
       0.18   11.4   1.6       0.23   11.0   0.2    1.9  2  DUF998         Protein of unknown function (DUF998)
        3.1    8.0   7.6         20    5.4   2.6    2.8  2  Zf_RING        KIAA1045 RING finger


Domain annotation for each model (and alignments):
>> Frag1  Frag1/DRAM/Sfk1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   4.2       3.9     1e+04     128     128 ..     941     941 ..     899     982 .. 0.49
   2 !   35.1  22.1   3.6e-12   9.3e-09       4     218 ..    1024    1301 ..    1021    1302 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 3.9
       Frag1 128 f 128
                  
  EFC37709.1 941 Q 941
                 2 PP

  == domain 2  score: 35.1 bits;  conditional E-value: 3.6e-12
       Frag1    4 llpliafilwlgmliamlvcavvqgpvdyvfmhkeqflPyISdigatnpeslffslalnlglflvilvallrfqrlpplatksern........... 89  
                  ++p ++++l+  +l++++v+++++ p+++ +     +lP +S++g ++p +++f+ +l++ ++ +i+ a+l+f   ++  t  + +           
  EFC37709.1 1024 YFPPVIVVLTAISLLFCIVLSLLTAPDSVSK-----HLPALSETGIFPPTKYIFTASLVIPSICLIVGAILQFITTKEKLTSLDHQrhtlnycngcf 1115
                  788888999999***************8875.....5**************************************8888887666667888999999 PP

       Frag1   90 ....lnfaalvlgligalglllvsif.....................................staeyhsvHlvgavvffvfgflyvllqtalyykm 145 
                      l++a++++ li+ ++ll+++i+                                         y ++Hl+++++f+  +f+ ++l+t+     
  EFC37709.1 1116 rmgwLSIASCIFALISGFCLLGLGIVpimggeviddsllsnsttsttvsfitsstsqqsaesiEILPYTIIHLIFTFFFMSTVFIHMVLNTIFNVLY 1212
                  9999***************************************************9966554444457899***********************999 PP

       Frag1  146 grhyvwnkstisfrlkvvllilavvla....ilfgvffvrhkkkc.............gygayslsAifEWllafwfiiffltfsvDFyt 218 
                   ++ +++k++i+  + +v ++ ++ ++    i+++++++  + +c                   l A+++++++ ++++f+lt+++DF++
  EFC37709.1 1213 DKK-ISPKKKILNPWVIVKIVSSCSFLvvgpIFSFIMGILVTVTCsqtevinktcplmNLFQLFLGALSQYSIVASILVFMLTYMYDFKD 1301
                  998.577777665544433333333330001334444444444449999*****997544445678**********************97 PP

>> zf-PARP  Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.9   7.1e-10   1.8e-06       1      78 [.     115     197 ..     115     201 .. 0.75
   2 ?   -3.8   2.0         7   1.8e+04       9      19 ..     261     271 ..     260     306 .. 0.88
   3 ?   -6.3   2.8         7   1.8e+04      49      53 ..     506     510 ..     495     522 .. 0.42

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 7.1e-10
                 EE-S-S--B-SSS--B--SSSEEEEE-...---..---EEEEHHHHHTSSS--S-GGG............EETTTTS-HHHHHHH CS
     zf-PARP   1 EyAksgrakCkkCkkkIakgelRlgkkveiees..eskrWyHvgCftekqiknkketkeieee.....eeiegfeeLekedqekv 78 
                 E +ksgr++Ck C k I+ g lR  +    +e+  ++++ +H+ Cf +  +++++ +++++ e      +i  + e  +++++ +
  EFC37709.1 115 EFSKSGRSSCKTCFKPIPYGVLRGYQD--NHENyyKAHECHHLTCFYKILLTENVREEDVKYEeekqkAAISKLYEFIAKEKKLI 197
                 789********************5554..444456**************999988887777766655445555555445555555 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 7
                 B-SSS--B--S CS
     zf-PARP   9 kCkkCkkkIak 19 
                 kC+ Ck++I++
  EFC37709.1 261 KCRYCKEQIKR 271
                 79999999974 PP

  == domain 3  score: -6.3 bits;  conditional E-value: 7
                 S--S- CS
     zf-PARP  49 iknkk 53 
                 +++k+
  EFC37709.1 506 KESKE 510
                 11111 PP

>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   1.3e-07   0.00034       1     112 [.     629     762 ..     629     800 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.3e-07
                    EEEE--STTTS--T...TTT......HHHHHHHHHH..HTSEEEEEE---TTTS-TTHHHHHHHHHHHHHHHTH...........HHHTETTCEEE CS
  Abhydrolase_3   1 lvyfHGGGfvlgsl...dth......dalcrelake..lgavvvsvdYrlAPehpfPaavedalaalrwlaeqa...........welgadpsriv 74 
                    ++++HGGGf++gs+   d +      +++ ++  ++  l   v+sv+YrlA + +f    +d  + ++ l +q            +e+++ ++ i+
     EFC37709.1 629 MLFIHGGGFISGSSlglDLQstvygiKDFNKKHKNNenLISHVLSVEYRLAEDPKFYET-MDKRTLTSNLSDQLedcfdcfkyliEEKNVPAKDII 723
                    69********99864332225577887777766555115567*********76666443.33444444444444444555555433589******* PP

                    EEEETHHHHHHHHHH.HHHHHTT---EEEEEEESE-SST CS
  Abhydrolase_3  75 laGdSaGGnlaaava.lrardegepkvagqvliyPvtdl 112
                    + G SaG+  +a ++  ++ +++++++  ++l++   dl
     EFC37709.1 724 ISGFSAGACHSALLVlKKLMNSQSWPLHSVALFSAPCDL 762
                    ********8877777245555557778888888775555 PP

>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   3.7e-05     0.095      88     145 ..     706     765 ..     618     782 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.7e-05
                    HHHHHHHHHHHHTT--GGGEEEEEETHHHH....HHHH.HHHT-SS--SEEEEES---TTGGG CS
  Abhydrolase_2  88 ekleelidaelkkgipssriiigGFSqGaa....laly.laltlpkklggivafsgalplsqk 145
                      ++ li+   +k +p+++iii GFS Ga     l+l+ l+ +++++l  +  fs  + ls +
     EFC37709.1 706 DCFKYLIE---EKNVPAKDIIISGFSAGAChsalLVLKkLMNSQSWPLHSVALFSAPCDLSNA 765
                    44444444...356**************85222255651455667799999999987766655 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0    0.0001      0.27      43      82 ..     699     738 ..     684     743 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0001
                   HHHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHHHHHHH CS
  Peptidase_S9  43 nefdDfiaaaealakegyvdserlaitGgSyGGyltgaal 82 
                    +++D++++ ++l++e+ v ++ ++i G S+G   ++ ++
    EFC37709.1 699 DQLEDCFDCFKYLIEEKNVPAKDIIISGFSAGACHSALLV 738
                   6789****************************98777665 PP

>> DUF998  Protein of unknown function (DUF998)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.2     9e-05      0.23       2      62 ..    1032    1092 ..    1031    1101 .. 0.85
   2 ?   -2.6   0.1       1.4   3.6e+03      68      91 ..    1120    1143 ..    1114    1161 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 9e-05
      DUF998    2 aaallalavilaaallrpgy.dplrhaiSeLgaeggpggwlfnaglvllgllvlalavgllr 62  
                  + a+ +l++i+++ l+ p+  +    a+Se g   +p++++f+a lv+  ++++++a++ + 
  EFC37709.1 1032 LTAISLLFCIVLSLLTAPDSvSKHLPALSETGI-FPPTKYIFTASLVIPSICLIVGAILQFI 1092
                  678889999999999999977777779999999.6*********************997655 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.4
      DUF998   68 agragrlllavaglglvlagvfpt 91  
                  ++ a++++  ++g++l++ g++p 
  EFC37709.1 1120 LSIASCIFALISGFCLLGLGIVPI 1143
                  444444445588888888888885 PP

>> Zf_RING  KIAA1045 RING finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.2     0.017        44      55      70 ..     199     214 ..     185     217 .. 0.84
   2 ?    5.4   2.6    0.0078        20       7      45 ..     261     299 ..     257     310 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.017
     Zf_RING  55 etGWsCaeCdnlnlLL 70 
                 +  W C++Cd  n LL
  EFC37709.1 199 KSKWQCTTCDGCNVLL 214
                 557************9 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0078
     Zf_RING   7 lCeiCevytaeelypCRvCtkvfHegClrklgylqdesa 45 
                  C  C+    + l++C  C+  f  +Cl++l+  +++++
  EFC37709.1 261 KCRYCKEQIKRVLFNCHQCNIGFCGECLKSLRWFDHKKH 299
                 5999***************************98876654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3065  (0.170952); expected 358.6 (0.02)
Passed bias filter:                      666  (0.0371465); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.26u 0.35s 00:00:01.61 Elapsed: 00:00:00.53
# Mc/sec: 7686.92
//
Query:       EFC37710.1  [L=650]
Description: phosphatidylinositol-4-phosphate 5-Kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-89  299.2   3.1    2.4e-89  299.2   3.1    2.7  2  PIP5K     Phosphatidylinositol-4-phosphate 5-Kinase
  ------ inclusion threshold ------
      0.065   13.2   0.1       0.14   12.1   0.1    1.5  1  Rad17     Rad17 P-loop domain


Domain annotation for each model (and alignments):
>> PIP5K  Phosphatidylinositol-4-phosphate 5-Kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.8   7.8         2   1.8e+04     172     194 ..      54     126 ..      27     195 .. 0.53
   2 !  299.2   3.1   2.6e-93   2.4e-89       4     271 ..     258     645 ..     255     647 .. 0.94

  Alignments for each domain:
  == domain 1  score: -5.8 bits;  conditional E-value: 2
                 ----------------------............................................................- CS
       PIP5K 172 keekkesessssekesekseee............................................................a 194
                 ++++k+++s++          +                                                            +
  EFC37710.1  54 NDDAKSTTSTN----------SslhqqqqqhselnisgnnlnvlvtpvaldgkseplsptahrratsissngypantpatpvH 126
                 11111111111..........01111122233455556666666666666666666666666666666666666655555552 PP

  == domain 2  score: 299.2 bits;  conditional E-value: 2.6e-93
                 -EEEE----SSS--EEEETTSSEEEEEE-HHHHHHHHHHHHHHHHHHTT-TT--S--EEEEEEEE.ETTEEEEEEEEE-SS-TTS--SEEEEE-S--TT CS
       PIP5K   4 alkelsseGkSgsffylteDkkfiiKtitksevkflrkllpeYyehvkenpnsLltrfyglhrvklkggkkvrfvVmenlfptdkeiheryDLKGstvg 102
                 +l+ l+++GkSg++f+++ D ++++Kt+tk+e+kflrk+lp+Yy+hv++npn+L+trfyg++++k++ggk+vrf+Vm+n+f+t++ ++eryDLKGstvg
  EFC37710.1 258 SLSILGTPGKSGALFFFSADMQYMLKTVTKKESKFLRKILPDYYNHVMANPNTLITRFYGMYSIKPRGGKNVRFIVMNNVFDTTMYVSERYDLKGSTVG 356
                 577899********************************************************************************************* PP

                 -S--HHHHTSSS-EEEHHHHHHHST.EEE-HHHHHHHHHHHHHHHHHHHHTTB-S-EEEEEEEB---------------------------........ CS
       PIP5K 103 ReakkkeeekkektlkDlDliekkeklklgkekreelleqlekDvefLeslnimDYSLLlGihnsekeekeekkesessssekesekseee........ 193
                 Rea++ke++++++ +kDlD+ ++++klk+g++ ++ +++ql+ D  +Le+++imDYSLL+G+h  + e + e  +++++ + k s+++  +        
  EFC37710.1 357 REASEKEKKRETPIYKDLDFLRRSSKLKVGPQMKNLIMNQLQVDATWLEKMKIMDYSLLVGVHRLDPELDAEVLKEAQNCNIKLSDSDIPSeafttvfn 455
                 **************************************************************9999877766665555544444443333378999*** PP

                 ................................................................................................... CS
       PIP5K 194 ................................................................................................... 193
                                                                                                                    
  EFC37710.1 456 hgssvasssmtstsylngtdqgtgassslnttnpisdhhdqvvnstdiaievsdeshptlngssstktientpsthhptsmstttqdsrkssestssff 554
                 *************************************************************************************************** PP

                 .............-----------------SEEEEESSSSEEEEEEEEE----B----------------------TTHHHHHHHHHHHHH CS
       PIP5K 194 .............aseeeeeseeeedeegekakeensedgkevyylgiIDiLqkynlkKklehalkslkkdkksisavpPkeYaeRFlkfi 271
                              ++ +  + +  ++ +g + +   ++ ++e+yy+giID Lqk+n kK++e+++k+l  d+++isav Pk+Ya RF+kf+
  EFC37710.1 555 grfmnhrlsvslkKHYRGPRASLFQQFHGGTLSLPLEDGSREIYYFGIIDLLQKWNNKKQIENIFKGLVADRNQISAVSPKNYAMRFVKFL 645
                 **********998788888888999999999999*******************************************************97 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.1   1.6e-05      0.14      73     122 ..      38      87 ..      14      96 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.6e-05
       Rad17  73 lrewlnpvslkepdn..qksdfkgltekesrflsqiesfkeleLkdakylkl 122
                     +n  +lk ++   +++d k+ t ++s++  q + ++el++ + + ++l
  EFC37710.1  38 A--DSNNNNLKATSEnhKNDDAKSTTSTNSSLHQQQQQHSELNISGNNLNVL 87 
                 3..345555565554459*************************999998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (650 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1563  (0.0871772); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.83u 0.34s 00:00:01.17 Elapsed: 00:00:00.49
# Mc/sec: 3953.95
//
Query:       EFC37711.1  [L=1030]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.03   13.7   4.9      0.059   12.8   4.9    1.4  1  SNAP        Soluble NSF attachment protein, SNAP
      0.046   14.0   0.2      0.093   13.0   0.2    1.5  1  TPR_12      Tetratricopeptide repeat
      0.085   13.1   3.5       0.77   10.0   2.3    2.8  2  ANAPC3      Anaphase-promoting complex, cyclosome, subunit 3
        1.3    8.7   3.3         62    3.3   0.1    4.0  4  Vac_Fusion  Chordopoxvirus multifunctional envelope protein A
        2.2    8.2   4.3       0.51   10.2   0.2    2.2  2  TPR_1       Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> SNAP  Soluble NSF attachment protein, SNAP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   4.9   1.6e-05     0.059     118     213 ..     664     760 ..     657     780 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.6e-05
                 HHHHHHHHHTT--HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHTT-HHHHHHHHHH...HHHTTSS-TTTGGGHHHHHHHHHHHHHHTT-HH CS
        SNAP 118 keiaelyekelgdlekAieaYekAaelyeqeeakalankcllkvAelsaelekyekAieiyek...vakkslennllkysvkeyflkaglcrLaagDvv 213
                   +++ y+k  ++++   ++ ++A e+y+q + +  a+ +l+ +A      +kye+Aie +e+   + k+++ +  +++s+ +yf + +l  ++ +++ 
  EFC37711.1 664 SAMCNYYKKR-KKYNMMYKYSKQAYEMYSQTGTSIYAQYILQTYATSCLFRKKYEEAIECFENnifLYKNQIPSTSVQTSLLDYF-NRILTFICDNEYF 760
                 6788999999.9999999999*************************999999**********94444589999999999999987.6778888877665 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   2.6e-05     0.093       9      69 ..     666     724 ..     659     725 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.6e-05
      TPR_12   9 laavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelle 69 
                 + + + ++++y    ++ ++a+e+++++  +++ ++  +l+++++ ++ +++yeeA+e +e
  EFC37711.1 666 MCNYYKKRKKYNMMYKYSKQAYEMYSQT--GTSIYAQYILQTYATSCLFRKKYEEAIECFE 724
                 6677889999******************..99**************************997 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.18   6.3e+02       5      33 ..     583     611 ..     580     615 .. 0.82
   2 ?   10.0   2.3   0.00021      0.77      33      81 ..     670     725 ..     644     726 .. 0.71

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.18
                 HHHHHHHHHHHH.HHH--HHHHHHHHHHH CS
      ANAPC3   5 yknAiflaerllaaetespedayllAlcl 33 
                 +kn+ +l+er  ++ t+  ed+y l l+l
  EFC37711.1 583 LKNIQILIERKISMFTDTTEDRYELNLSL 611
                 589999******999********985544 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00021
                 HHHTT-HHHHHHHHHCT.SHHHC-H......HHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3  33 lylngqykrAyellrka.klnsksl......gcrylfAqcllkLkkyeeAiaaLek 81 
                 + ++++y+  y++ ++a + +s++        ++ ++A ++l  kkyeeAi ++e+
  EFC37711.1 670 YKKRKKYNMMYKYSKQAyEMYSQTGtsiyaqYILQTYATSCLFRKKYEEAIECFEN 725
                 55556666666666666555555542233224444689***************986 PP

>> Vac_Fusion  Chordopoxvirus multifunctional envelope protein A27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.54   1.9e+03      34      48 ..     169     180 ..     168     186 .. 0.77
   2 ?    2.8   0.0     0.025        88       3      22 ..     235     254 ..     212     260 .. 0.58
   3 ?   -3.5   0.0       2.3   8.2e+03      44      52 ..     515     523 ..     510     524 .. 0.76
   4 ?    3.3   0.1     0.017        62      26      43 ..    1011    1028 ..    1007    1030 .] 0.86

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.54
                 H-XXXXXXXXXXXXX CS
  Vac_Fusion  34 EnHleTlRkamlaLa 48 
                 En l TlRk +   +
  EFC37711.1 169 ENSLKTLRKQL---T 180
                 88999***975...4 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.025
                 HHHHHHHHHHHHHHHHHHHH CS
  Vac_Fusion   3 kdleerllvlekdfqlvikc 22 
                   l+ r+ ++++++++v+ c
  EFC37711.1 235 DTLISRIHNVNNEYEKVFYC 254
                 34555555555555555555 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 2.3
                 XXXXXXXXX CS
  Vac_Fusion  44 mlaLakKID 52 
                 +l+L kK D
  EFC37711.1 515 LLDLEKKFD 523
                 789999988 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.017
                  HHHHHHHHH-XXXXXXXX CS
  Vac_Fusion   26 vnealkRlEnHleTlRka 43  
                   +e+ kR  nH + +R +
  EFC37711.1 1011 RKERFKRFDNHCDCIRFN 1028
                  57999**********965 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.5   0.7         5   1.8e+04       9      17 ..     668     676 ..     666     677 .. 0.77
   2 ?   10.2   0.2   0.00014      0.51      12      26 ..     711     725 ..     707     732 .. 0.80

  Alignments for each domain:
  == domain 1  score: -4.5 bits;  conditional E-value: 5
                 HHHHHTT-H CS
       TPR_1   9 nayfklgky 17 
                 n y k +ky
  EFC37711.1 668 NYYKKRKKY 676
                 679999998 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00014
                 HHTT-HHHHHHHHHH CS
       TPR_1  12 fklgkydeAleyyek 26 
                 +  +ky+eA+e++e 
  EFC37711.1 711 LFRKKYEEAIECFEN 725
                 5679*********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1030 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1307  (0.0728987); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.84u 0.30s 00:00:01.13 Elapsed: 00:00:00.51
# Mc/sec: 6078.11
//
Query:       EFC37712.1  [L=676]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.2e-29   99.8 170.1    0.00045   20.5  12.0   11.2 11  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   1.6      0.16   2.8e+03      10      15 ..     129     134 ..     123     139 .. 0.56
   2 !   16.4   9.9     5e-07     0.009       5      32 .]     146     172 ..     142     172 .. 0.88
   3 !   20.1  10.3   3.4e-08   0.00061       8      32 .]     188     211 ..     181     211 .. 0.86
   4 !   18.6  10.0     1e-07    0.0018       4      32 .]     223     250 ..     216     250 .. 0.87
   5 !   16.2   9.4   5.6e-07      0.01       4      32 .]     262     289 ..     259     289 .. 0.86
   6 !   14.0   8.4   2.8e-06      0.05       4      32 .]     301     328 ..     294     328 .. 0.87
   7 !   17.0  11.4   3.2e-07    0.0057       5      32 .]     341     367 ..     333     367 .. 0.89
   8 !   19.6  10.6   4.7e-08   0.00085       5      32 .]     380     406 ..     377     406 .. 0.91
   9 !   20.5  12.0   2.5e-08   0.00045       4      32 .]     418     445 ..     415     445 .. 0.88
  10 !   15.7   7.2   8.4e-07     0.015       5      32 .]     458     484 ..     454     484 .. 0.87
  11 !    4.9   1.0    0.0019        35       5      15 ..     640     650 ..     634     653 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.16
       EGF_2  10 ghGtCv 15 
                 g+G+C+
  EFC37712.1 129 GGGYCN 134
                 455665 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 5e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G C++ + +C+C+ gy+G++C
  EFC37712.1 146 STVCNSNGNCIDVN-NCSCSYGYSGANC 172
                 678*******9777.8************ PP

  == domain 3  score: 20.1 bits;  conditional E-value: 3.4e-08
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 C++hGtC +  + C+C+s+y+G +C
  EFC37712.1 188 CSNHGTCAS-YNTCSCSSNYYGSNC 211
                 *******84.459************ PP

  == domain 4  score: 18.6 bits;  conditional E-value: 1e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s+e C+g G+Cv+ +  C+C s+y+G++C
  EFC37712.1 223 SSEVCSGKGICVDYN-SCSCVSNYYGPDC 250
                 3899*******9666.7************ PP

  == domain 5  score: 16.2 bits;  conditional E-value: 5.6e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+ghG+C + +  C+C  +y+G +C
  EFC37712.1 262 NSDVCSGHGSCTDYN-SCSCYLNYYGSNC 289
                 5689*******8555.7************ PP

  == domain 6  score: 14.0 bits;  conditional E-value: 2.8e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s+e C g+G+C +    C+C++ ++G++C
  EFC37712.1 301 SSEVCLGRGICAEVD-DCHCEFDFTGNNC 328
                 3799*******9555.7************ PP

  == domain 7  score: 17.0 bits;  conditional E-value: 3.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G C +++ +C+C+sg++G+ C
  EFC37712.1 341 SSVCSSRGLCSSPN-NCSCQSGFFGNEC 367
                 789********999.8************ PP

  == domain 8  score: 19.6 bits;  conditional E-value: 4.7e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+  G+C +++ +C C++gy+G+ C
  EFC37712.1 380 SQVCSSSGVCSSPN-NCTCNDGYTGDEC 406
                 468********999.8************ PP

  == domain 9  score: 20.5 bits;  conditional E-value: 2.5e-08
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++  C+ghG C  + ++C C+sgy+G++C
  EFC37712.1 418 NSKVCSGHGDCS-FYNNCTCESGYFGNDC 445
                 3789*******8.6889************ PP

  == domain 10  score: 15.7 bits;  conditional E-value: 8.4e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C      C+C+s+++G +C
  EFC37712.1 458 SSVCSGNGNCTMHD-TCSCKSHFTGLSC 484
                 689*******8555.8*********999 PP

  == domain 11  score: 4.9 bits;  conditional E-value: 0.0019
       EGF_2   5 deiCgghGtCv 15 
                 ++ C+g+G C 
  EFC37712.1 640 SSVCSGNGNCT 650
                 689*******6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (676 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1316  (0.0734006); expected 358.6 (0.02)
Passed bias filter:                      255  (0.0142228); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.30s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 3841.22
//
Query:       EFC37713.1  [L=1913]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-52  174.9 280.0      1e-05   25.8   8.9   18.6 19  EGF_2     EGF-like domain
    4.8e-25   88.3  18.8    2.9e-22   79.1  16.6    2.6  2  REJ       REJ domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.0   3.6         2   1.8e+04       7      23 ..      34      48 ..      30      53 .. 0.59
   2 !   13.8  10.2   6.6e-06     0.059       5      32 .]     236     263 ..     232     263 .. 0.86
   3 !   23.0   8.8   8.6e-09   7.7e-05       7      32 .]     278     302 ..     273     302 .. 0.92
   4 !   19.3   7.1   1.2e-07    0.0011       5      30 ..     316     340 ..     312     341 .. 0.91
   5 !   18.3  10.4   2.5e-07    0.0022       5      32 .]     354     380 ..     351     380 .. 0.92
   6 !    8.6   4.1   0.00027       2.4      14      32 .]     423     440 ..     422     440 .. 0.94
   7 !   24.8  11.3   2.3e-09   2.1e-05       5      32 .]     453     479 ..     450     479 .. 0.92
   8 !   19.8  12.3   8.3e-08   0.00075       5      32 .]     491     517 ..     484     517 .. 0.89
   9 !   22.7   9.8     1e-08   9.4e-05       6      32 .]     531     556 ..     527     556 .. 0.90
  10 !   17.9   7.5   3.4e-07     0.003       4      32 .]     568     595 ..     565     595 .. 0.91
  11 !   23.1  10.5   7.7e-09   6.9e-05       4      32 .]     607     634 ..     605     634 .. 0.92
  12 !   24.7   8.2   2.5e-09   2.2e-05       5      32 .]     647     673 ..     643     673 .. 0.91
  13 !   25.8   8.9   1.1e-09     1e-05       6      32 .]     687     712 ..     682     712 .. 0.91
  14 !   14.4  11.5   4.3e-06     0.038       5      32 .]     724     750 ..     717     750 .. 0.90
  15 !   15.4   5.1     2e-06     0.018       4      25 ..     761     782 ..     759     794 .. 0.78
  16 !    9.9  11.0   0.00011      0.96       1      32 []     812     846 ..     812     846 .. 0.74
  17 ?   -3.2   0.2       1.3   1.2e+04      23      32 .]     849     858 ..     848     858 .. 0.89
  18 !    6.7   1.2     0.001       9.3       6      32 .]    1539    1563 ..    1534    1563 .. 0.86
  19 ?   -0.4   0.5      0.17   1.6e+03      17      25 ..    1830    1838 ..    1828    1841 .. 0.73

  Alignments for each domain:
  == domain 1  score: -5.0 bits;  conditional E-value: 2
       EGF_2  7 iCgghGtCvnqcG.qCdC 23
                +Cgg  +C   ++ +C C
  EFC37713.1 34 TCGG-NICF--GNdNCLC 48
                4554.3565..2225877 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 6.6e-06
       EGF_2   5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 ++ C+ghGtC ++   CdC ++ y+G +C
  EFC37713.1 236 STVCSGHGTCTKTD-TCDCeSTTYSGSNC 263
                 678*******8566.8***999999***9 PP

  == domain 3  score: 23.0 bits;  conditional E-value: 8.6e-09
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ghG+Cv+++  C+C+sgy+G +C
  EFC37713.1 278 VCSGHGSCVAPN-SCSCSSGYSGEDC 302
                 7********999.7************ PP

  == domain 4  score: 19.3 bits;  conditional E-value: 1.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++ C+g+G+C++++ +C+C sgy+G+
  EFC37713.1 316 SSVCSGRGSCIAPN-NCSCASGYFGD 340
                 578********999.8*********7 PP

  == domain 5  score: 18.3 bits;  conditional E-value: 2.5e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+g+G+C++++ +C+C++ ++G++C
  EFC37713.1 354 SSACSGQGSCISPN-NCSCSNDHYGNDC 380
                 578********999.8************ PP

  == domain 6  score: 8.6 bits;  conditional E-value: 0.00027
       EGF_2  14 CvnqcGqCdCdsgyqGktC 32 
                 C++++ +C+C  gy+G++C
  EFC37713.1 423 CISPN-NCSCLVGYYGNDC 440
                 99999.8************ PP

  == domain 7  score: 24.8 bits;  conditional E-value: 2.3e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG+Cv+++ +C+C+sgy+G++C
  EFC37713.1 453 GSVCSGHGSCVASN-NCSCSSGYYGNDC 479
                 789********888.8************ PP

  == domain 8  score: 19.8 bits;  conditional E-value: 8.3e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+ghG+C +++ +C+C sgy+G +C
  EFC37713.1 491 SSACSGHGSCLSPN-NCSCVSGYYGSDC 517
                 689********999.8************ PP

  == domain 9  score: 22.7 bits;  conditional E-value: 1e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C++hG+C++++ +C+C sgy+G+ C
  EFC37713.1 531 SSCSNHGSCISPN-NCSCLSGYYGNEC 556
                 57********999.8************ PP

  == domain 10  score: 17.9 bits;  conditional E-value: 3.4e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C+ hG+C +++ +C+C  gy+G+ C
  EFC37713.1 568 SGSVCSRHGSCLSPN-NCSCLVGYYGNEC 595
                 4899********999.8************ PP

  == domain 11  score: 23.1 bits;  conditional E-value: 7.7e-09
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C+ hG+C++++ +C+C+sgy+G++C
  EFC37713.1 607 SGSVCSRHGSCISPN-NCSCSSGYYGNDC 634
                 5889********999.8************ PP

  == domain 12  score: 24.7 bits;  conditional E-value: 2.5e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C +hG+C++++ +C+C+sgy+G +C
  EFC37713.1 647 ASVCTNHGSCISPN-NCSCSSGYSGSDC 673
                 578********999.8************ PP

  == domain 13  score: 25.8 bits;  conditional E-value: 1.1e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+GtC++++ +C+C++gy+G++C
  EFC37713.1 687 FVCSGNGTCNSPN-NCSCSAGYFGNDC 712
                 57********999.8************ PP

  == domain 14  score: 14.4 bits;  conditional E-value: 4.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+g G C+++   C+C++gy+G +C
  EFC37713.1 724 ASACSGKGRCDSFD-HCSCQPGYSGSDC 750
                 578********999.9************ PP

  == domain 15  score: 15.4 bits;  conditional E-value: 2e-06
       EGF_2   4 s.deiCgghGtCvnqcGqCdCds 25 
                 + ++ C+ghG+C +++  C+Cds
  EFC37713.1 761 NaSSVCSGHGKCTDFN-TCVCDS 782
                 45789*******9999.9***65 PP

  == domain 16  score: 9.9 bits;  conditional E-value: 0.00011
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                 C a  ++C+g+G+C++++ qC C     +  + G +C
  EFC37713.1 812 CNA-TTTCSGNGYCNDLE-QCTCfadnkKGFWKGESC 846
                 555.479***********.****77664444556666 PP

  == domain 17  score: -3.2 bits;  conditional E-value: 1.3
       EGF_2  23 CdsgyqGktC 32 
                 C +g +G  C
  EFC37713.1 849 CADGVYGELC 858
                 999****999 PP

  == domain 18  score: 6.7 bits;  conditional E-value: 0.001
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++C+ghG  + ++ +C+C+  y+  +C
  EFC37713.1 1539 TDCSGHGFLI-KE-KCVCEEDYTTSDC 1563
                  57*******9.45.8*******99999 PP

  == domain 19  score: -0.4 bits;  conditional E-value: 0.17
       EGF_2   17 qcGqCdCds 25  
                    G+C+C+ 
  EFC37713.1 1830 NYGNCECSE 1838
                  4699*9975 PP

>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0   7.6e-05      0.68      81     131 ..     967    1011 ..     947    1090 .. 0.77
   2 !   79.1  16.6   3.3e-26   2.9e-22     109     444 ..    1196    1510 ..    1106    1516 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 7.6e-05
         REJ   81 spLvavIkGGssrvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsq 131 
                  ++ +a I+G ++ + g  +++ +d+seSy pd++      l+++W++    
  EFC37713.1  967 KRPIATISG-AKETYGSCEDVLIDASESYSPDRK-----ALNFKWTVLLAP 1011
                  555788888.888999999999*********888.....499999994444 PP

  == domain 2  score: 79.1 bits;  conditional E-value: 3.3e-26
         REJ  109 yDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpeals...gtll.ssstssltfpaselvanltynftltvskrsrksasteqtilvvdge 201 
                   Dp+ +   + q +Y+W+c+++               +++a++   ++ l +    + ++ +s + +  +  ++l+++k+sr  +s++  il ++ e
  EFC37713.1 1196 TDPESE---NVQPTYSWTCVNTV--------------TNTACPaavVNYLsQGVLEQYKIEKSIVGSAENVRISLNIQKGSRSVQSSVDLILPQQAE 1275
                  455444...37899*****4444..............22333322224440445559999999999999*************99**********999 PP

         REJ  202 pplv..siecisncngkvnpndrlvllas.clncakdlkdvt.feWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdk 294 
                    ++   i+ ++  + kvn+ d + ++ + + n ++++ ++   +W l      + +l   ++ss++ +++   L +++++L++g+s +++l+v d 
  EFC37713.1 1276 NVIMppLISVVQVSSSKVNKGDYVSVQLVvTINGDSNIDQFItRTW-LLNDKAIDAVLTSPMSSSPSLSNS---LILDTQYLDEGSSNTISLTVLDN 1368
                  98884469999999********99999888999999955555599*.777778888888888999999998...******************99999 PP

         REJ  295 egkksglasisfkvnepPtgGtcsvtPlegvaletaftvrCqgwtDkdqPLgYevsys.qrrasgpyrllyegsnnisisviLPvGppqqdykvtvm 390 
                  + +++   s+sf+vn pP  ++c + P++gval+t f+++C++ +++++  +Y+++y   ++ sg+   l++ ++      +LP++++  +++++++
  EFC37713.1 1369 RNNQKTSYSYSFSVNRPPKACSCAISPTSGVALTTIFNFNCENCQNDKK--TYAFEYGfIDDFSGSFISLSKDEE---LYQKLPTPNS--GNNLELY 1458
                  888888***********************************99955554..577755505555665555554444...4889999999..889**** PP

         REJ  391 vsVyDnkgarv.svsltitVkppavnnstieellenrtrnenelskllesgdtqr 444 
                  v+V D+   ++   + ++++++p+v+n   +e++++ t+  n++s+ll sgd  r
  EFC37713.1 1459 VKVIDTETLATtLSKQSVQITAPSVENV--MEVKDYITK-WNAISSLLPSGDYAR 1510
                  *******9999677889***********..888888876.589999999999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1913 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       964  (0.0537676); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.13u 0.30s 00:00:01.43 Elapsed: 00:00:00.55
# Mc/sec: 10447.54
//
Query:       EFC37714.1  [L=997]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-22   77.9   1.9    5.2e-06   26.6   0.0    4.5  4  SPRY      SPRY domain


Domain annotation for each model (and alignments):
>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.0   0.0   9.7e-06      0.17       2     115 ..     206     322 ..     205     325 .. 0.79
   2 !   24.2   0.0   1.6e-09   2.8e-05       2     113 ..     379     492 ..     378     498 .. 0.78
   3 !   26.6   0.0   2.9e-10   5.2e-06       4     116 ..     557     674 ..     554     678 .. 0.65
   4 !   11.3   0.0   1.6e-05      0.28       2      87 ..     735     823 ..     734     834 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 9.7e-06
                 EEEEEEETCCTSSEEEEEEEETTSSSSSTSSS...TSSTTEEEEET....ETTEEEEETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTEEEEEEE CS
        SPRY   2 hyfevkiqsaeggsisvGlateqtdlsdksge...gddrgswglcg....dngtrtsaeqskaygkqparegdviGvalDleegelsFtkngknlgvaF 93 
                 + + vki+ + ++ + +G+a++++   d+++     d+ g + l+     +n +  s+++ +  ++ ++  gd     l++ ++el  + n+ ++ +  
  EFC37714.1 206 YKWNVKIN-TIKSWLAIGVAHTHIG-DDHKFAfspYDEHGAYMLSAngyiWNRQLASTNKYEYVANSNFVAGDLMSLELNCGKRELVIYRNNGKVATIN 302
                 78*****9.999999******9998.677777777666677777764455666666999999999999**********************998876543 PP

                 ESTTTSSEEEEEEE.STCEEEE CS
        SPRY  94 rnvrgaelfPvvslgngaslki 115
                  +++  +++P ++++  +s+++
  EFC37714.1 303 -DIPL-PVYPSFMMHGMESVEF 322
                 .3555.8888888877777665 PP

  == domain 2  score: 24.2 bits;  conditional E-value: 1.6e-09
                 EEEEEEETCCTSSEEEEEEEETTSSSSSTSSS..TSSTTEEEEET....ETTEEEEETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTEEEEEEEE CS
        SPRY   2 hyfevkiqsaeggsisvGlateqtdlsdksge..gddrgswglcg....dngtrtsaeqskaygkqparegdviGvalDleegelsFtkngknlgvaFr 94 
                 + + +ki+  + + i +G++ +++ + + + +   d+ g + ++     +++    +++ +++g  +   gd+i   l++ ++el+ tk gknl  +F+
  EFC37714.1 379 FKWRIKIL-STTSWIGLGVVAKEIAQGRFHNLspYDNHGGYIYSLngygWSAFYEGTNKYTNCGA-SCSAGDIITLELNCASKELTLTKEGKNLI-TFK 474
                 57999**9.777788899999999988888877744444455554222244444399999*****.***************************96.688 PP

                 STTTSSEEEEEEE.STCEE CS
        SPRY  95 nvrgaelfPvvslgngasl 113
                 +v   +++P+v+++  +s+
  EFC37714.1 475 QVHL-PVYPFVMMHGMESV 492
                 7877.******99876666 PP

  == domain 3  score: 26.6 bits;  conditional E-value: 2.9e-10
                 EEEEETCCTSSEEEEEEEE.TTSSSSSTSSS..TSSTTEEEEET....ETTEEEEETESCEEEESSSSTTSEEEEEEETTTTEEEEEETT.EEEEEEEE CS
        SPRY   4 fevkiqsaeggsisvGlat.eqtdlsdksge..gddrgswglcg....dngtrtsaeqskaygkqparegdviGvalDleegelsFtkng.knlgvaFr 94 
                 ++vki+ +      +G+ + e+++ls+++     d++g + ++     ++ ++ +  + k  ++ +++egdvi + l+++++el+F+kn  +n   + +
  EFC37714.1 557 YKVKIN-KLANWAGIGMIKkENVNLSTYQSYspYDNNGAFIISAngyvWDDNM-KDPKYKLVETAKFTEGDVIIIELNCITRELNFYKNIiTNKMATIE 653
                 566666.3333334666431334444444433345555555444334444444.66677777888*************************555566666 PP

                 STTTSSEEEEEEE.STCEEEEE CS
        SPRY  95 nvrgaelfPvvslgngaslkin 116
                 nv+  +++P+ +l  ++ +++ 
  EFC37714.1 654 NVSL-PVYPFLMLYGKEEVEFL 674
                 6655.********988888875 PP

  == domain 4  score: 11.3 bits;  conditional E-value: 1.6e-05
                 EEEEEEETCCTSSEEEEEEEETTSSSSSTSSS..TSSTTEEEEET....ETTEEEEETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTE CS
        SPRY   2 hyfevkiqsaeggsisvGlateqtdlsdksge..gddrgswglcg....dngtrtsaeqskaygkqparegdviGvalDleegelsFtkngk 87 
                 + ++v+i+    + i +G++++++  +++      dd gs+ l+     +n +   +  sk  g  ++++gdv    lD+++++l   k g 
  EFC37714.1 735 FKWQVRIL--SLSWIGLGVTRREVAAKSNLSVspYDDHGSYFLSAngyvWNRQLADPYYSKIEGA-TYQKGDVLVFTLDCKQQSLQIAKSGV 823
                 78******..***************6666655888999998888755666666667777777777.999****************9988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (997 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       784  (0.043728); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.92u 0.35s 00:00:01.27 Elapsed: 00:00:00.56
# Mc/sec: 5348.96
//
Query:       EFC37715.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-26   93.6   0.0    2.4e-25   89.7   0.0    2.0  1  Amino_oxidase  Flavin containing amine oxidoreductase
    8.3e-10   38.8   0.0    2.2e-09   37.4   0.0    1.8  2  NAD_binding_8  NAD(P)-binding Rossmann-like domain
    1.9e-07   31.0   0.0    8.2e-07   28.9   0.0    1.9  2  DAO            FAD dependent oxidoreductase
    0.00053   19.5   0.0    0.00075   19.0   0.0    1.2  1  FAD_oxidored   FAD dependent oxidoreductase
    0.00063   19.1   0.0      0.033   13.4   0.0    2.2  2  Pyr_redox_2    Pyridine nucleotide-disulphide oxidoreductase
     0.0023   17.1   0.0     0.0038   16.4   0.0    1.3  1  FAD_binding_2  FAD binding domain
     0.0071   15.1   0.0      0.074   11.7   0.0    2.0  2  HI0933_like    HI0933-like protein
     0.0099   15.2   0.2       0.89    8.7   0.0    2.4  2  Pyr_redox_3    Pyridine nucleotide-disulphide oxidoreductase
  ------ inclusion threshold ------
      0.013   14.8   0.0      0.022   14.0   0.0    1.3  1  Thi4           Thi4 family
       0.04   14.5   0.3        6.7    7.4   0.1    2.5  2  F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
      0.095   12.7   0.5        2.6    8.0   0.1    2.8  3  NAD_binding_9  FAD-NAD(P)-binding
       0.15   12.6   0.4        1.8    9.2   0.1    2.5  2  Pyr_redox      Pyridine nucleotide-disulphide oxidoreductase


Domain annotation for each model (and alignments):
>> Amino_oxidase  Flavin containing amine oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   89.7   0.0   1.6e-28   2.4e-25       1     447 [.      43     474 ..      43     474 .. 0.76

  Alignments for each domain:
  == domain 1  score: 89.7 bits;  conditional E-value: 1.6e-28
                    HHHHHHHHHHHHTT.EEEEEEESSSSSBTTS-EEEET.TEEEESS--EEETTTHHHHHHHHHTTCCCCEEEESCCGCEEEEETTEECCTTEECHHH CS
  Amino_oxidase   1 laGLaaArqLlsaG.fdVtvlEardrvGGRirtvrsd.GylielGamwftgagnpllellkelgledslslpdpgapkrvlskggrefpgdlspvp 94 
                    ++G  +A+qL+ +G  ++ v+E++dr+GGR+ t+ ++ + +++ G+ +++++++ + +l+kel++ ++          ++l+      + + ++++
     EFC37715.1  43 ISGVFTAYQLAKNGkNNICVVESTDRLGGRLETFTLGnSKKYDIGGIRVNNQHTVMKNLAKELNITLVGG--------YYLD------KSEAQDLN 124
                    89***********************************88**************************98443........5566......67777777 PP

                    HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH..........HHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHTSTT CS
  Amino_oxidase  95 aewealleqgalsaellsleeklrlgleall..........qktldeldldskslaesleelgrrepgdvevwdrliepelfaklefasglfagdp 180
                     + + l+      +  +s+++k  l  +a +              ++ +    s++++  ++ + ++g  e ++++          f +   +gd+
     EFC37715.1 125 LPSNVLMV-----SRDVSTNDKNVLRSQAYPkatgavsgwdVLLGTSSEFFINSTLQDTFSFTQAGLGSAEEMSYFQST-------FRF---RGDF 205
                    77777777.....455556666666666666333333333322225555556666666666777777776666666663.......222...2233 PP

                    TTCBHHHHTCCCCHHHHHTSCCCEETTHTHHHHHHHHH...TTTTEEEETSEEEEEEEE..ETTC..EEEEETTSTEE.EESEEEE-S-HHHHHSS CS
  Amino_oxidase 181 selsaklalpllwelegfggslllprgGlsqlpealae...elrgldirlntrVkeikr..egdg..vtvtledgevv.eaDaVvvTvplgvlkai 268
                      +  + ++ +  ++   +   ++p gG+++ ++ ++    ++++++++l++ V  i+   + ++   + +++++  + ea+ Vv+++p+ +lk i
     EFC37715.1 206 -QAVDRKTYAEFANVDSIDPLNFYPVGGMGEFVRKMSLiaqQSGKVRFLLSETVQTINPhsS-STtnKKYRIQTCLRNiEAKNVVIAIPPLALKDI 299
                    .2233344444444444444456679*********988888******************852.3335666666777668***************66 PP

                    EEES..CCSHHHHHHHHHSEEEEEEEEEEEESSGGSGCSTSECECECCCEEETTTEEEEECCECCCSTTTEEE..EEEEEECHHHHHHHTTS.... CS
  Amino_oxidase 269 lfsP..plpdekaeairnlgfgsvnkvilefdrkfwednalgqgvlvseltttlgeafissdfpsrappgkgl..vllvyvggdaanelesl.... 356
                    + s    l   +  a+++ +  +v+ + ++f++++we+ +     +  +++t++    +    p+  p+g       ++y  g  a+e+++l    
     EFC37715.1 300 KGSIaaTL--NAEPAFKQSKPLPVSTITMRFQQRWWEQAS-----PARRIWTDSNCIQLIE-IPIT-PSGIESnaFRVSYADGHCAREWNDLylgg 386
                    66665588..9**************************976.....6666666666555553.4444.233322334677777*******99999*9 PP

                    -HHHHHHHHHHHHHHHHT.GTSSTCSEEEEEECCTETTTSSSEEE.BTTHHHHHHHHHHCH.HCSTTEEE.SGGGCTTTTTS.HHHHHHHHHHH CS
  Amino_oxidase 357 sdeelvqavlrdLrklfg.eevpepkatlvtrWhtdplargsysyvsvgpghedydplakp.egdprlffAGehtsreypgt.vegAilSGlra 447
                     ++ + + +l++L  +++  ++p+p +t+ + W  d+++   +  +s+ +   d +++a +  +  ++++ Ge+ +  +  t   gA++S++ a
     EFC37715.1 387 GKSLIEKTILQYLTAIYPgVSIPQPLETVFKLWP-DAWY---FEQPSAAVTLADKQKWALNpIQNENVVLVGEAFH--LERTwSVGAVKSAIDA 474
                    *********************************9.****...888888888888888888855557**********..99999999**999865 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.4   0.0   1.5e-12   2.2e-09       1      66 [.      38     103 ..      38     105 .. 0.83
   2 ?   -3.4   0.0       8.1   1.2e+04      19      51 ..     249     281 ..     242     285 .. 0.67

  Alignments for each domain:
  == domain 1  score: 37.4 bits;  conditional E-value: 1.5e-12
                    EE--SHHHHHHHHHHHCCTE.EEEEE-SSSSSSGGG-EECETT.CEECTS---EEETTHHHHCHHHHC CS
  NAD_binding_8   1 IvGaGlsGlvaAylLakagf.dvlllekrdrlGGraasyevpg.vrvdygahifhgsgyypnvrrllr 66 
                    I+G+G+sG  +Ay Lak+g+ ++ ++e+ drlGGr+ ++++++  ++d g   ++   +++ +++l++
     EFC37715.1  38 ILGGGISGVFTAYQLAKNGKnNICVVESTDRLGGRLETFTLGNsKKYDIGGIRVNN--QHTVMKNLAK 103
                    89****************8858*******************766999988777666..2455555555 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 8.1
                    TEEEEEE-SSSSSSGGG-EECETTCEECTS--- CS
  NAD_binding_8  19 gfdvlllekrdrlGGraasyevpgvrvdygahi 51 
                    +++ ll e+ + +  +++s +++++r+++  + 
     EFC37715.1 249 KVRFLLSETVQTINPHSSSTTNKKYRIQTCLRN 281
                    456666677677777788888888888877766 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   0.0   5.5e-10   8.2e-07       1      33 [.      35      70 ..      35     156 .. 0.96
   2 ?   -0.2   0.0       0.4     6e+02     147     199 ..     235     290 ..     170     323 .. 0.79

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 5.5e-10
                EEEEECTSHHHHHHHHHHHHTT...EEEEESSSSTT CS
         DAO  1 dvviiGGGiiGlstAyeLarrg...Vtllekgdiag 33
                d +i GGGi G++tAy+La+ g   ++++e+ d++g
  EFC37715.1 35 DYAILGGGISGVFTAYQLAKNGknnICVVESTDRLG 70
                789******************999*******99988 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.4
                 HHHHHHHHHHHHTT.-EEEESECEEEEEEEE....TCEEEEEEECT.EEEEEEEEEEE- CS
         DAO 147 kltaalaraaealG.veilegtevtgleeed....gkvwgverttp.gendaadavVna 199
                 ++++ +   a++ G v++l+ ++v+ ++ ++    +k +++  +t   ++ +a+ vV+a
  EFC37715.1 235 EFVRKMSLIAQQSGkVRFLLSETVQTINPHSssttNKKYRI--QTClRNI-EAKNVVIA 290
                 67788888888888899999999999955444555454666..3432322.34668877 PP

>> FAD_oxidored  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.0     5e-07   0.00075       3      38 ..      37      73 ..      35     122 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 5e-07
  FAD_oxidored  3 vVvGGgpaGvaAAiaAaraGa.kvlLveergvlGGll 38
                   + GGg++Gv  A++ a++G+ + ++ve +++lGG l
    EFC37715.1 37 AILGGGISGVFTAYQLAKNGKnNICVVESTDRLGGRL 73
                  799*****************95689**********76 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.0   2.2e-05     0.033     130     178 ..      18      70 ..       6     118 .. 0.75
   2 ?    3.4   0.0     0.025        37      60     235 ..     243     291 ..     197     316 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.2e-05
                  CHHHHHHCCSS-T...SEEEEES-SHHHHHHHHHHHHHT-E.EEEEESSSSSS CS
                  xxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxx RF
  Pyr_redox_2 130 ldsaealklkllp...krivvvGgGyiGvElAaalaklgke.vtlveardrll 178
                  ++sa+      +p    + ++ GgG  Gv +A +lak gk+ + +ve  drl 
   EFC37715.1  18 VHSADSTTTTATPtlaCDYAILGGGISGVFTAYQLAKNGKNnICVVESTDRLG 70 
                  44455555555554446779999999999999999999998899999999997 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.025
                  HHCHHHHCCCCHCCTCEEEEESCEEEEETEEEC.TCEEEEEESEEEE---EEE-BCTCTTC.TTBEECCSECHHHHHHCCSS-TSEEEEES-SHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2  60 vkklnqgielllgeevvkidpgkkkvklekkke.gdeekiaydklvlAtGssprdlgipGvaenvgklvrtldsaealklkllpkrivvvGgGyiGvE 156
                  + +++ ++++ll e+v +i p +   + +k +     ++i+++++v+A                                                  
   EFC37715.1 243 IAQQSGKVRFLLSETVQTINPHSSSTTNKKYRIqTCLRNIEAKNVVIA-------------------------------------------------- 290
                  333344455555544555544442222222221244445555555555.................................................. PP

                  HHHHHHHHT-EEEEEESSSSSSTTS-HHHHHHHHHHHHHTTEEEEESCEEEEEEETTEEEEEEETTSCEEEESEEEE-S CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 157 lAaalaklgkevtlveardrllraldkelsaaleealekeGvevklgtsvkeidgngeklevvledgeeidadlvvvav 235
                                                                                                +
   EFC37715.1 291 ------------------------------------------------------------------------------I 291
                  ..............................................................................4 PP

>> FAD_binding_2  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   2.5e-06    0.0038       1      37 [.      35      72 ..      35      79 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.5e-06
                   SEEEE--SHHHHHHHHHHHHTTT.-EEEEESSSGGGSG CS
  FAD_binding_2  1 DviViGsGlAGLaAAleaaeaGl.kvavvekeqefgga 37
                   D  + G+G++G   A+++a++G+ +++vve +++ gg 
     EFC37715.1 35 DYAILGGGISGVFTAYQLAKNGKnNICVVESTDRLGGR 72
                   6789****************************999984 PP

>> HI0933_like  HI0933-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.0   4.9e-05     0.074       2      39 ..      35      73 ..      34      80 .. 0.85
   2 ?    1.0   0.0     0.093   1.4e+02     113     162 ..     239     291 ..     225     308 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.9e-05
                 SEEEE--SHHHHHHHHHHHHTT-.-EEEE-SSSSS-HHH CS
  HI0933_like  2 dviviGgGaAGlmaAisaakrgk.rVlllekakklgrKi 39
                 d +++GgG +G+++A ++ak+gk ++ ++e++++lg ++
   EFC37715.1 35 DYAILGGGISGVFTAYQLAKNGKnNICVVESTDRLGGRL 73
                 779***************88775278999*999999766 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.093
                  HHHHHHHHHHT-EEE-S--EEEE....ECETTE.EEEEE.TTEEEEESEEEE-- CS
  HI0933_like 113 dallkelkeagvklrletevksv....ekeedgkfrvktkseeeleadklvlAt 162
                  ++ l + ++ +v++ l+++v+++    ++++++k+r++t   +++ea+++v+A+
   EFC37715.1 239 KMSLIAQQSGKVRFLLSETVQTInphsSSTTNKKYRIQT-CLRNIEAKNVVIAI 291
                  555666677889999999999997776666777899999.999*********95 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0    0.0006      0.89     158     194 ..      27      63 ..       4      81 .. 0.56
   2 ?    3.9   0.1     0.018        27      97     132 ..     251     291 ..     237     292 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0006
  Pyr_redox_3 158 efhkyagqkvvViGgknSavDaAlelvrkgaeVtvvt 194
                   ++++   ++++ Gg+ S+v +A++l+++g++   v+
   EFC37715.1  27 TATPTLACDYAILGGGISGVFTAYQLAKNGKNNICVV 63 
                  4455556666666666666666666666665422222 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.018
  Pyr_redox_3  97 piklfeeVesvkk.....edegfevetsketyeAkkviiAt 132
                  +  l e+V+++++     ++++++++t  +++eAk+v+iA+
   EFC37715.1 251 RFLLSETVQTINPhssstTNKKYRIQTCLRNIEAKNVVIAI 291
                  5556778888876332224678*****************95 PP

>> Thi4  Thi4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   1.5e-05     0.022      17      55 ..      33      71 ..      22      77 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.5e-05
                EEEEEEE--SHHHHHHHHHHHHCTTS-EEEEESSSS--T CS
        Thi4 17 esDvvivGaGssGLtaayylakkpdlkvailersvspGG 55
                  D +i G+G sG+ +ay lak+ + +++++e+   +GG
  EFC37715.1 33 ACDYAILGGGISGVFTAYQLAKNGKNNICVVESTDRLGG 71
                57999******************999******9988887 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.1    0.0045       6.7       2      34 ..      36      66 ..      35      99 .. 0.86
   2 ?    4.8   0.0     0.028        42       6      84 ..     232     306 ..     230     312 .. 0.61

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0045
                   EEEETTSHHHHHHHHHHHHTTS-GGCEEEEEES CS
  F420_oxidored  2 igiiGaGnmgealasgllaagaqpheivvansr 34
                    +i+G+G  g   a +l+++g  +++i+v+ s 
     EFC37715.1 36 YAILGGGISGVFTAYQLAKNG--KNNICVVEST 66
                   59*******************..9999987443 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.028
                    TTSHHHHHHHHHHHHTTS...-GGCEEEEEESSCCCHHHHHHHHC-EEECECHHHHHHH-SEEEE-S-HHHHHHHHHHCGHH CS
  F420_oxidored   6 GaGnmgealasgllaaga...qpheivvansrnpekaeelaeelgvkvtavdneeaaeeadvvvlavkpedveevlselakd 84 
                    G+G++ + + + ++++g+     +e v   + np++   + +++ ++++   n ea      vv+a++p +++++  ++a+ 
     EFC37715.1 232 GMGEFVRKMSLIAQQSGKvrfLLSETV--QTINPHSSSTTNKKYRIQTCL-RNIEAK----NVVIAIPPLALKDIKGSIAAT 306
                    566666666666666664433222222..234566666666666666666.555555....5************99988544 PP

>> NAD_binding_9  FAD-NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.92   1.4e+03     112     133 ..       6      27 ..       2      33 .. 0.79
   2 ?    8.0   0.1    0.0017       2.6       1      36 [.      37      68 ..      37      75 .. 0.80
   3 ?    0.8   0.0      0.28   4.2e+02      82     152 ..     219     290 ..     187     292 .. 0.60

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.92
  NAD_binding_9 112 pegvtvevhraevvdleeradg 133
                    pe v++evh+++v++ + + ++
     EFC37715.1   6 PELVDIEVHQEKVHSADSTTTT 27 
                    67899*********99887765 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0017
  NAD_binding_9  1 aivGaGprGlavlerLlarakkkspleitlfdpsep 36
                   ai G+G++G+ ++ +L+++     + +i +++ +  
     EFC37715.1 37 AILGGGISGVFTAYQLAKNG----KNNICVVESTDR 68
                   799****************5....777888887444 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.28
  NAD_binding_9  82 aeeldpddfvpRalyGrYlrdlfeellarlpegvtvevh.raevvdleeradg....qavlladgaslaadaVvLA 152
                    ++++dp +f p   +G+++r++   ++++ +    v+++ +++v  ++++ ++     + +++  ++++a++Vv+A
     EFC37715.1 219 VDSIDPLNFYPVGGMGEFVRKMSLIAQQSGK----VRFLlSETVQTINPHSSSttnkKYRIQTCLRNIEAKNVVIA 290
                    5668889999999999999998777776664....44442344444555443311113455677788999999998 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.1    0.0012       1.8       3      36 ..      37      72 ..      35      99 .. 0.86
   2 ?    0.6   0.0      0.58   8.6e+02      54      72 ..     249     267 ..     233     274 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0012
                EEECSSHHHHHHHHHHHHTT.SEEEEEESSSSSS.T CS
   Pyr_redox  3 vvvGgGyiglElAgalaelg.kkVtvversdkll.r 36
                +++GgG +g+  A  la+ g +++ vve  d+l  r
  EFC37715.1 37 AILGGGISGVFTAYQLAKNGkNNICVVESTDRLGgR 72
                79**************99883588999999999844 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.58
                 TEEEECSEEEEEEEEETTS CS
   Pyr_redox  54 gievllntkveeiegsedg 72 
                 ++++ll+++v+ i+ +++ 
  EFC37715.1 249 KVRFLLSETVQTINPHSSS 267
                 89***********988764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       453  (0.0252663); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.43
# Mc/sec: 3425.67
//
Query:       EFC37716.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-18   67.4   2.3    9.3e-18   64.4   0.8    2.1  2  D123      D123
    0.00049   20.0   0.0     0.0051   16.7   0.0    2.1  2  R2K_2     ATP-grasp domain, R2K clade family 2
  ------ inclusion threshold ------
      0.038   14.1   0.7        2.2    8.4   0.1    2.5  2  HTH_54    ParA helix turn helix domain
       0.05   13.3   0.3        1.3    8.7   0.3    2.3  2  DUF3755   Protein of unknown function (DUF3755)


Domain annotation for each model (and alignments):
>> D123  D123
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.018        82      68     104 ..      75     116 ..      57     129 .. 0.77
   2 !   64.4   0.8   2.1e-21   9.3e-18     104     280 ..     154     328 ..     144     344 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.018
                 ----...HHHHHHHHHHHHHTTS-.....EEEE-SS---GGG CS
        D123  68 eepseefpeleekikeaieelgga.....vfpKlnwsaPkDA 104
                 e++  e+++++++i+++++el+++      ++Kl   +PkD 
  EFC37716.1  75 EQDLMELKQVSDNIEKIMKELNENnyrdgFIVKLTSRSPKDI 116
                 235688999999999999998764333337899999999995 PP

  == domain 2  score: 64.4 bits;  conditional E-value: 2.1e-21
                 GCCTSSSSSS-BSSHHHHHHHHHT-HHHHHHHHHTTTTBT--TTS-S-TT----EEEEE--.---GGGEEEEEEETTEEEEEEESSS.S--THHHHTHH CS
        D123 104 AawilaenslkctsvndvylLLksSdfiahDLehafdeceeeeeesekeeieleLvLrkwf.dlnpslefRcFVkdrkLiaisqRdl.nyydfleelke 200
                 A + ++ + l++ ++++ + LL  S+ i  DL    d        + +++++l Lv+r w  ++  ++efR  V + +L ++sq  +  y + le++ke
  EFC37716.1 154 ALYFASLQCLRVYNAQEAISLLSQSSRIEYDL--LLDL-------TFESDFSLGLVVRPWDaNMTLESEFRGIVYNGELKCLSQYFTqCYLESLEKDKE 243
                 455666677899999*****************..3333.......46778**********88***********************997899******** PP

                 HHHHHHHHHHHT..TTTSSSS.....SEEEEEEEETT.....EEEEEEEEESSTTS--TTS-HHHHH.....HS-TTSSS-EEE---- CS
        D123 201 elkekieeffeeklkekfpde.....syvfDvyvpkk...ldkvkliDinpfaertdslLFtweeLleeeeeeeeeeeeepelrlves 280
                 e++++++eff++++k+ ++++     +y++D  ++k+   + +vkl+ inp+ ++t   LF+we+ +   e   e+ ++++e+r++++
  EFC37716.1 244 EIEKHCKEFFSTTIKPVLQEHapeltNYIVDFSLTKNeanQFSVKLLEINPYLTTTGVGLFDWEKDT---EPLFENPKSQFEFRILTE 328
                 ***************99886445555*******9999666678********************9755...7888999999****9944 PP

>> R2K_2  ATP-grasp domain, R2K clade family 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0       0.1   4.7e+02      33      59 ..      68      94 ..      61      99 .. 0.88
   2 !   16.7   0.0   1.1e-06    0.0051      60     129 ..     207     294 ..     204     302 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.1
       R2K_2 33 tgavvedgedlpglgsldedlpvlvse 59
                +g+v+e+++dl++l++++++++ +++e
  EFC37716.1 68 KGTVMENEQDLMELKQVSDNIEKIMKE 94
                689****************99988877 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 1.1e-06
       R2K_2  60 vvsfasEyRlfvldgeiitvsrYagegrl...dpdp..............evaeeavaalksalpsayvlDvgvtedg....etalvEand 129
                  ++++sE+R  v +ge+ ++s+Y  +  l   +  +              ++++ ++++++ +    y +D+ +t+++     ++l E+n+
  EFC37716.1 207 NMTLESEFRGIVYNGELKCLSQYFTQCYLeslE--KdkeeiekhckeffsTTIKPVLQEHAPE-LTNYIVDFSLTKNEanqfSVKLLEINP 294
                 5899***********************996442..1557888899977777777777777766.788*********965556788888886 PP

>> HTH_54  ParA helix turn helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.018        80       3      26 ..      79     102 ..      77     126 .. 0.86
   2 ?    8.4   0.1    0.0005       2.2      10      56 ..     236     285 ..     228     291 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.018
      HTH_54   3 kmLqelteqiqkqkkElkedeyyq 26 
                 + L++++++i+k  kEl+e++y  
  EFC37716.1  79 MELKQVSDNIEKIMKELNENNYRD 102
                 56999***************9955 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0005
      HTH_54  10 eqiqkqkkEl..kedeyyqtyskaalak.lpklsrrkvdkavsemeaeGy 56 
                 e+++k+k+E+  + +e++ t  k  l++  p+l+  +vd ++++ ea+ +
  EFC37716.1 236 ESLEKDKEEIekHCKEFFSTTIKPVLQEhAPELTNYIVDFSLTKNEANQF 285
                 678999**9966678********99975279***********99998755 PP

>> DUF3755  Protein of unknown function (DUF3755)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.3   0.00029       1.3      12      27 ..      82      97 ..      81      98 .. 0.90
   2 ?    1.9   0.0      0.04   1.8e+02       4      14 ..     168     178 ..     166     180 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00029
     DUF3755 12 cqtRdNImaIlndMsd 27
                 q+ dNI +I++++++
  EFC37716.1 82 KQVSDNIEKIMKELNE 97
                5899**********97 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.04
     DUF3755   4 lqeNidLFcqt 14 
                 +qe+i+L+ q 
  EFC37716.1 168 AQEAISLLSQS 178
                 6*******985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1077  (0.0600703); expected 358.6 (0.02)
Passed bias filter:                      600  (0.0334653); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.41
# Mc/sec: 2575.09
//
Query:       EFC37717.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.3e-23   81.5  24.8    8.7e-23   80.8  24.8    1.3  1  Ion_trans    Ion transport protein
    1.2e-09   38.0   7.8    1.2e-09   38.0   7.8    3.0  2  Ion_trans_2  Ion channel
  ------ inclusion threshold ------
       0.27   11.2   0.0       0.27   11.2   0.0    2.4  3  Sensor       Putative sensor
        2.2    8.8   4.9       0.62   10.6   1.1    2.0  2  DUF4231      Protein of unknown function (DUF4231)


Domain annotation for each model (and alignments):
>> Ion_trans  Ion transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.8  24.8     2e-26   8.7e-23       4     240 ..     228     478 ..     221     483 .. 0.85

  Alignments for each domain:
  == domain 1  score: 80.8 bits;  conditional E-value: 2e-26
                 HHHHHHHHHHHHHHHHHCCCSSSSHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHTH..HHHHHHCHSHHHHHHHHHHHHHHHHH........HHHH... CS
   Ion_trans   4 felfilllillncvflaletyfpedelektileilelvftaiftlemllkilalgl..likkrYlrdpwnilDflvvlpsllsl........vlse... 89 
                 +++++ +++l+++++l le+  +  ++e + + i+e +   +ft+e  l++++  +  +++k ++ +++n++D+++ +p++l++               
  EFC37717.1 228 IAIIVNFIVLISVIVLILESFAELYQFE-NTWWIIEGILAFFFTVEYMLRLIGNIYskKDAKYFFFNIMNLIDLMSFIPYYLEVvlyyifryS--Lgqd 323
                 4455556669999999998888887888.9999********************7778999**********************99666655550..0556 PP

                 .......HHHHHHHHHHHHGGGGGGHHHCHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSCCCCCC.....SCCSTSSSTTTSSS. CS
   Ion_trans  90 .......esllllsvlrlfrvlrllklisrleglrtlvtalirsvkdllnvlllllvvlfifaligvqlfkgklrekne.....caktwenpnngntn. 175
                        ++l ++ v+r++r+l+++ l+++++++r l+ a+ rsv  ll v+++++  +fi + + +    g++ ++ +     +      p +g+t+ 
  EFC37717.1 324 hyitsmvMNLQIIGVFRVLRLLKVFTLTKHSGKVRLLLIAIRRSVDLLLAVIYFVIATVFILGTLIYYAERGTFDHELKafvrfS------PLDGKTKe 416
                 667777789***********************************************99***999999999999998833443332......22222222 PP

                 ...SSSHHHHHHHHHHHHTTSSHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans 176 ...FdnfftallwlfrlmttegwgdilyatldekskvaliyfvifiilgsflllNlliaviadnfqel 240
                    F+n+++ ++ ++ ++tt g+gd++++t+ +k      + +++ il ++l+++l+  +i  +++e+
  EFC37717.1 417 ispFSNILMGMWYSLISITTTGYGDMIPVTIIGK------LIGTISILTGLLIVALPSMIIGRTYSEV 478
                 3359******************************......*************************997 PP

>> Ion_trans_2  Ion channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   4.5       2.6   1.2e+04      14      14 ..     243     243 ..     212     280 .. 0.53
   2 !   38.0   7.8   2.6e-13   1.2e-09       3      75 ..     379     473 ..     377     477 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.6
                  H CS
  Ion_trans_2  14 y 14 
                   
   EFC37717.1 243 L 243
                  1 PP

  == domain 2  score: 38.0 bits;  conditional E-value: 2.6e-13
                  HHHTCHHHHHHHHT..........................T---HHHHHHHHHHHHTTS----SSTT-----HHHHHHHHHHHHHHHHHHHHHHH CS
  Ion_trans_2   3 lllvlifgaviysl......................eegwekwsfldalYfsfvtltTiGYGdivpetdagrlftivyillGlalfalflavlgk 75 
                  + +v+i+g++iy+                       +e++   ++l  +++s++++tT GYGd++p+t +g+l+ ++ il+Gl+++al   ++g+
   EFC37717.1 379 IATVFILGTLIYYAergtfdhelkafvrfspldgktKEISPFSNILMGMWYSLISITTTGYGDMIPVTIIGKLIGTISILTGLLIVALPSMIIGR 473
                  55667777777777788888888888888888888766666789999**************************************9987766665 PP

>> Sensor  Putative sensor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   6.1e-05      0.27      74     140 ..     194     267 ..     168     285 .. 0.61
   2 ?   -0.0   0.7      0.18   8.1e+02       6      23 ..     370     386 ..     359     393 .. 0.69
   3 ?   -3.2   0.8       1.7   7.6e+03       9      36 ..     426     453 ..     420     476 .. 0.52

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6.1e-05
      Sensor  74 llarlrallrdpatwrdllylllhfplg.lvlfvvavvl.lalalalltaPlw.....tlpeallvavlGllll 140
                 ll+++    r+++twr+ lyll+  p +  ++f +a+++ +++ ++ +++ l        +e    ++ G+l++
  EFC37717.1 194 LLKNVIPKKREERTWRHRLYLLMNQPQSsKWAFLIAIIVnFIVLISVIVLILEsfaelYQFENTWWIIEGILAF 267
                 56666667799***************997555555555543333333333331334441344444444444444 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.18
      Sensor   6 lplgvaafvllvtglslg 23 
                 l+l+v++fv +++ ++ g
  EFC37717.1 370 LLLAVIYFVIATVFIL-G 386
                 5677777777766333.3 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 1.7
      Sensor   9 gvaafvllvtglslglgllvllvGlplL 36 
                 g+ + +  +t++  g ++ v+++G ++ 
  EFC37717.1 426 GMWYSLISITTTGYGDMIPVTIIGKLIG 453
                 5555555555555555555555554332 PP

>> DUF4231  Protein of unknown function (DUF4231)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   1.1   0.00014      0.62      39      73 ..     224     258 ..     207     259 .. 0.87
   2 ?   -2.5   0.1       1.6   7.4e+03      22      36 ..     454     468 ..     426     482 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00014
     DUF4231  39 lgagvsvlkiltallsalvailaaleeffrykerW 73 
                 ++    ++  +++l+s++v il+++ e+++++++W
  EFC37717.1 224 WAFLIAIIVNFIVLISVIVLILESFAELYQFENTW 258
                 555667788899*********************** PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.6
     DUF4231  22 litivlgallpilvs 36 
                  i+i++g l+ +l s
  EFC37717.1 454 TISILTGLLIVALPS 468
                 344444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1305  (0.0727871); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.50
# Mc/sec: 3655.65
//
Query:       EFC37718.1  [L=761]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (761 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1255  (0.0699983); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.48
# Mc/sec: 4735.61
//
Query:       EFC37719.1  [L=475]
Description: hypothetical protein NAEGRDRAFT_81833 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2807.85
//
Query:       EFC37720.1  [L=519]
Description: Cyclin_N domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-18   66.9   0.2      1e-17   64.1   0.1    2.3  2  Cyclin_N  Cyclin, N-terminal domain
    3.5e-06   27.1   2.3    3.5e-06   27.1   2.3    2.6  3  Cyclin_C  Cyclin, C-terminal domain
  ------ inclusion threshold ------
       0.23   11.5   1.8       0.51   10.4   0.6    2.3  2  TUDOR     Tudor domain


Domain annotation for each model (and alignments):
>> Cyclin_N  Cyclin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.1   0.1   1.7e-21     1e-17       7     126 ..     204     332 ..     198     333 .. 0.87
   2 ?   -0.2   0.0      0.13   7.8e+02      72      87 ..     392     407 ..     369     466 .. 0.70

  Alignments for each domain:
  == domain 1  score: 64.1 bits;  conditional E-value: 1.7e-21
                 HHHHCHTS-STTCTTCTSSS-HHHHHHHHHHHHHHHHHTT--TTHHHHHHHHHHHHHHHS---CC......CHHHHHHHHHHHHHHHHSSS---HHHHH CS
    Cyclin_N   7 ieqelkflpkpdyldqqpelnpemRailidwlvevaekfkltpetlflavnyldRflskksvpkd......klqlvgatcLllAaKveeisppkledlv 99 
                 i++e+  + k +yl+++p+++p++R+++idw   +++++++ +e+l++a  ++dR l + +++++      +lq +g++c ++++K+    +++l+d+ 
  EFC37720.1 204 ISRETINCAKANYLSTHPHVKPQYRRTVIDWFNILQTELDIPKEILYHATMIFDRSLDRFNIEQYylidvdNLQALGCACFFISTKYYGR-SVNLSDIL 301
                 5678889999******************************************************99*********************666.56666665 PP

                 HHT..TT..SS-HHHHHHHHHHHHHHTTT-- CS
    Cyclin_N 100 yit..de..afteeeilemErliLetLnfdl 126
                   +  d+     ++++l+mE  +L+tL+f+l
  EFC37720.1 302 PPVssDSsiEDLKKQVLRMESWVLNTLDFEL 332
                 43322443333489***************98 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.13
                 CHHHHHHHHHHHHHHH CS
    Cyclin_N  72 klqlvgatcLllAaKv 87 
                 +  lv+++c +lA ++
  EFC37720.1 392 RPSLVALSCFVLAFQM 407
                 5679999999999777 PP

>> Cyclin_C  Cyclin, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       1.8   1.1e+04      77      81 ..      28      32 ..       8      59 .. 0.54
   2 !   27.1   2.3   5.8e-10   3.5e-06      14      62 ..     364     415 ..     335     495 .. 0.68
   3 ?   -0.5   0.1      0.21   1.3e+03      10      36 ..     475     513 ..     457     514 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.8
                HHHHH CS
    Cyclin_C 77 edlkp 81
                + ++ 
  EFC37720.1 28 DSVET 32
                22222 PP

  == domain 2  score: 27.1 bits;  conditional E-value: 5.8e-10
                 SSHT.-HCCHHCHHCHHHHHHCSCCHCCS-HHHHHHHHHHHCCHHH....HS- CS
    Cyclin_C  14 adasedselrtlakylleltlldydflsyppSliAaaalllarstl....nsp 62 
                 ad+  +  ++++++yl+e+ l +yd+l ++pSl+A ++++la ++l    n +
  EFC37720.1 364 ADNFVN-FMEKVSNYLCEIQLHNYDMLWFRPSLVALSCFVLAFQMLaphsNFK 415
                 444445.8899**********************************95444322 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.21
                 HHCCSSHT.-HCCHHCHHC.............HHHHHHCS CS
    Cyclin_C  10 flkaadasedselrtlaky.............lleltlld 36 
                  lk+ + +++ ++rt++ky             l+el+++d
  EFC37720.1 475 SLKNHNRNRE-HFRTITKYypaiapfisqpeqLIELSIQD 513
                 4555555555.77777777666666666666688888877 PP

>> TUDOR  Tudor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.6   8.5e-05      0.51      11      59 ..     124     173 ..     119     182 .. 0.82
   2 ?   -2.6   0.0      0.89   5.3e+03      35      74 ..     451     466 ..     417     475 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 8.5e-05
                 EEEEEETTEEEEEEGGHHHHHHHHHHHHHHHHTSSCC.TCSSS--TT-EE CS
       TUDOR  11 vsaiespskfyiqpkeqskkleklteelqeyyaskkk.aellapavgegc 59 
                 +++  s + f i+p++ s+++e++ ++++e+  s+++ +++++ ++ ++ 
  EFC37720.1 124 ITCSWSATSFSIHPEKESQQYETMEDSVEEIILSQDHdSNSNQEECANQD 173
                 67778999***************************997666666665555 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.89
                 HHHHHHHHTSSCCTCSSS--TT-EEEEEETTTTEEEEEEE CS
       TUDOR  35 teelqeyyaskkkaellapavgegcvavfsedgkwyRAki 74 
                 + e++e+                         +++ R+ +
  EFC37720.1 451 VIEIEEFN------------------------NCMKRCLV 466
                 33333333........................34444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (519 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1877  (0.104691); expected 358.6 (0.02)
Passed bias filter:                      613  (0.0341904); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 3036.21
//
Query:       EFC37721.1  [L=285]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.3e-05   24.6   0.0    3.5e-05   24.0   0.0    1.4  1  Polyketide_cyc  Polyketide cyclase / dehydrase and lipid tran


Domain annotation for each model (and alignments):
>> Polyketide_cyc  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   1.9e-09   3.5e-05       9     107 ..     112     215 ..     105     255 .. 0.80

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 1.9e-09
                     HHHHTTTGGCCSCCCCEEEEEE.SSSEE......E................EEECSTTSSCEEEEEEEEEEETTTEEECTTCCCCCEEEEEEEEC CS
  Polyketide_cyc   9 yalvadvesypeflphcssvevleeaes...glsa................dlevgfggltesftarvtldppeeitfklvegdfkslegkWtie 84 
                      ++++d+e+ypefl ++  + v++++++      +                  +++  +++ + ++ + l  +e+         fk++ g+W ++
      EFC37721.1 112 LDIITDFERYPEFLDGYFVANVHRKETKqdyT--VtfkssfmfstveytlqVKVISPEHIQFNSSSSNCLINCES--------SFKKHGGQWILK 196
                     589************************96541..25567888888999998889999999999999998888888........************ PP

                     TECCEEECEEEEEEEEEEEE-SS CS
  Polyketide_cyc  85 slppnsggtrtkvalevdfkfas 107
                      l+    g+  + ++ v+++  s
      EFC37721.1 197 DLKN---GN-IQATYFVNMEYPS 215
                     **95...44.6666666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1776.51
//
Query:       EFC37722.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.62   10.2   8.4        2.4    8.3   2.0    2.6  2  Med9      RNA polymerase II transcription mediator complex su


Domain annotation for each model (and alignments):
>> Med9  RNA polymerase II transcription mediator complex subunit 9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   2.0   0.00013       2.4      50      78 ..     222     250 ..     220     252 .. 0.89
   2 ?    5.3   0.8    0.0011        20      36      72 ..     250     288 ..     249     295 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00013
        Med9  50 rsveeqeaeieeleeqlakKrelLkkykn 78 
                 r++e++++e++++++ +++K+ lL+  ++
  EFC37722.1 222 RTTEQRDEEVRKKRQYMEMKQHLLSTSNQ 250
                 89**********************97665 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0011
        Med9  36 kkarelirelpg..idrsveeqeaeieeleeqlakKrel 72 
                 +++ + i++l+   +d +  +qe+ ++++e++l++    
  EFC37722.1 250 QECEQPIMSLKKvkLDNTSNDQEDLLQTYEKELQNLLHI 288
                 567777888888889******************987655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1504  (0.0838864); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.30s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 2451.39
//
Query:       EFC37723.1  [L=441]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-17   62.8   0.0    8.5e-17   62.4   0.0    1.1  1  NIT       Nitrate and nitrite sensing
  ------ inclusion threshold ------
      0.023   13.7   0.0      0.087   11.8   0.0    1.8  2  Ter       DNA replication terminus site-binding protein (Ter 


Domain annotation for each model (and alignments):
>> NIT  Nitrate and nitrite sensing
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.4   0.0   9.5e-21   8.5e-17       6     219 ..     131     363 ..     126     367 .. 0.74

  Alignments for each domain:
  == domain 1  score: 62.4 bits;  conditional E-value: 9.5e-21
         NIT   6 LQkERglsagylasgggerkaaelaaqraatDaalaalr...........alaglarrldallrald.......qLpalRrqv.d...trkldakeava 82 
                 LQ+ERg +++yl+s + ++ + ela++r++tD a++++            + ++ +r+   + + l        +++++R +v +   ++ l+  + ++
  EFC37723.1 131 LQNERGITSLYLGSHK-RQYTIELAEARNRTDNAIERFFalsvspndiliN-EQWKRTWYLFEDYLGkvigyskGVGEWRMKVeNvtnETFLPTIQYIN 227
                 9************974.577888**************66688999976653.34455555555556334446679********5564433788888899 PP

         NIT  83 aYtdviaaLldladelaqgspdrelarqlralaalsrakEalsqerallaaalaagrfsaalyaaflslvar....qqaalaefraaatpa.qralyde 176
                  ++++i+++++++++ + +   ++ a   ++++ ls a+E+ ++ r +++ ++ +g++s+a+ ++f ++v +    +      f+  a+ +   +++++
  EFC37723.1 228 DWDSLINDMIRVVTSQSLD---PTFAIIHNSFNLLSAAREYRGIRRIYGTFGFMNGSLSQASIDSFKEAVIKgilvR----HLFSLQASNEiYTEFLTN 319
                 ************9887765...99*********************************************99955553....444333333322234444 PP

         NIT 177 tvtgpavkaaetlrdrlastggv..daed....e.eeWfaastaridqlr 219
                 +++++  +  ++++d       v  + ++    + eeWf ++t  ++  r
  EFC37723.1 320 ILNDTQQNICQSMEDY------VldNYQNltkyTlEEWFFNMTLCMNSFR 363
                 4444444555555555......222444453344889******9999877 PP

>> Ter  DNA replication terminus site-binding protein (Ter protein)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   9.7e-06     0.087      88     153 ..     205     270 ..     198     279 .. 0.91
   2 ?   -1.8   0.0      0.14   1.3e+03     170     209 ..     320     360 ..     318     371 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 9.7e-06
         Ter  88 GvlcfsvsnaekaelealieeiNklKaeleeiitvesglekeerFefvhrhlpglitlnayRkltl 153
                 G   ++v+n ++++   +i+ iN+    ++++i v ++ + +  F ++h++++ l     yR ++ 
  EFC37723.1 205 GEWRMKVENVTNETFLPTIQYINDWDSLINDMIRVVTSQSLDPTFAIIHNSFNLLSAAREYRGIRR 270
                 55678999**************************9999899*********************9986 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.14
         Ter 170 ikkltreevleqLek.slkapravapytreqwqekveqeiq 209
                 i + t++++++ +e   l + + +++yt e+w  +++  ++
  EFC37723.1 320 ILNDTQQNICQSMEDyVLDNYQNLTKYTLEEWFFNMTLCMN 360
                 55668899999999978899999999999999877766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       645  (0.0359752); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.24s 00:00:00.81 Elapsed: 00:00:00.43
# Mc/sec: 3092.98
//
Query:       EFC37724.1  [L=460]
Description: TPR repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.6e-49  162.0  12.6    7.9e-07   28.6   0.0   10.8 10  TPR_1       Tetratricopeptide repeat
    6.9e-43  141.3   2.9      9e-06   25.4   0.0   10.3 10  TPR_2       Tetratricopeptide repeat
    4.2e-31  104.5  14.6     0.0061   16.7   0.0   10.1 10  TPR_8       Tetratricopeptide repeat
    4.6e-21   74.9   0.1      0.001   19.3   0.0    7.5  6  TPR_12      Tetratricopeptide repeat
    2.5e-20   71.3   2.2    0.00013   22.1   0.0    9.6 10  TPR_17      Tetratricopeptide repeat
    7.3e-19   67.1   0.2       0.16   12.7   0.0    9.6 10  TPR_6       Tetratricopeptide repeat
    8.6e-19   67.5   0.0      6e-06   26.3   0.0    5.9  6  TPR_9       Tetratricopeptide repeat
    3.1e-17   62.9   0.0      0.002   18.7   0.0    6.6  6  TPR_16      Tetratricopeptide repeat
    4.6e-17   61.4  13.4    0.00011   21.8   0.0    9.9 11  TPR_11      TPR repeat
    3.9e-16   58.3   0.0     0.0028   18.3   0.0    8.1  9  TPR_14      Tetratricopeptide repeat
    1.5e-12   47.8   0.1      0.013   16.0   0.0    5.1  6  TPR_19      Tetratricopeptide repeat
    8.3e-07   29.3   0.4       0.67   10.3   0.0    3.8  3  TPR_20      Tetratricopeptide repeat
      9e-07   28.5   5.0        1.2    9.3   0.1    6.7  6  TPR_7       Tetratricopeptide repeat
    1.8e-05   24.4   2.0        4.7    7.2   0.0    6.2  6  TPR_10      Tetratricopeptide repeat
    0.00013   21.9   4.9       0.78    9.9   0.1    5.3  5  MIT         MIT (microtubule interacting and transport) domai
    0.00019   21.6   9.5       0.46   10.8   1.6    4.9  8  ANAPC3      Anaphase-promoting complex, cyclosome, subunit 3
     0.0094   15.9   1.7       0.12   12.4   0.1    3.2  2  TPR_3       Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.01   15.3   0.8       0.24   10.8   0.0    3.1  3  Coatomer_E  Coatomer epsilon subunit
      0.048   14.2   1.6       0.66   10.5   0.0    2.9  2  Pox_H7      Late protein H7
      0.066   13.6   4.3       0.45   10.9   1.3    3.3  2  MitMem_reg  Maintenance of mitochondrial structure and functi
      0.094   13.2   0.0         22    5.4   0.0    3.1  2  BTAD        Bacterial transcriptional activator domain
      0.098   12.9   1.5       0.53   10.5   0.2    2.8  3  FliJ        Flagellar FliJ protein
       0.39   10.9   2.3         18    5.6   0.0    3.5  4  SMBP        Small metal-binding protein
       0.52   10.9   4.0         15    6.2   0.2    4.3  4  DUF5344     Family of unknown function (DUF5344)


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.0   1.7e-07   0.00013       1      26 [.       5      30 ..       5      31 .. 0.94
   2 !   16.4   0.0   7.6e-06    0.0057       2      30 ..      57      85 ..      56      89 .. 0.94
   3 !   13.0   0.1   9.1e-05     0.068       3      33 ..     105     135 ..     103     136 .. 0.93
   4 !   10.5   0.1   0.00056      0.42       6      29 ..     149     172 ..     145     175 .. 0.92
   5 !   11.0   0.1   0.00039      0.29       2      34 .]     192     224 ..     191     224 .. 0.96
   6 !   28.6   0.0   1.1e-09   7.9e-07       3      34 .]     227     258 ..     227     258 .. 0.94
   7 !   15.1   0.0     2e-05     0.015       3      34 .]     261     292 ..     259     292 .. 0.96
   8 !   16.4   0.0   7.7e-06    0.0057       3      31 ..     344     372 ..     342     375 .. 0.91
   9 !   14.2   0.4   3.9e-05     0.029       2      34 .]     377     410 ..     376     410 .. 0.93
  10 !   11.9   0.0   0.00021      0.16       8      34 .]     418     444 ..     412     444 .. 0.94

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 1.7e-07
                HHHHHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_1  1 akalynlGnayfklgkydeAleyyek 26
                +ka+  +G+ay +l k++eA++++e+
  EFC37724.1  5 VKAHLSRGLAYSNLSKHQEAIQDFEQ 30
                589*********************98 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 7.6e-06
                HHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1  2 kalynlGnayfklgkydeAleyyekALel 30
                k++y +G+  ++l++++  l+  +kA++l
  EFC37724.1 57 KSWYLKGVSERSLKNHENSLKSLDKAIKL 85
                89*************************98 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 9.1e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPn 33 
                  +  +G+++  +++y++  + ++k ++l+P+
  EFC37724.1 105 YYMTRGLIFNDQKNYEKSTKNFRKFIKLCPE 135
                 5889********************9999996 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 0.00056
                 HHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyyekALe 29 
                 nlG  + kl k deA e+y++A++
  EFC37724.1 149 NLGIGLEKLDKEDEAFEAYSEAIS 172
                 9*********************97 PP

  == domain 5  score: 11.0 bits;  conditional E-value: 0.00039
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALelnPnn 34 
                 +++y +G++  k++   +++++y+ +L+ nPn+
  EFC37724.1 192 DTYYYRGLLSEKKESSMKCIADYDFVLRYNPNH 224
                 68*****************************97 PP

  == domain 6  score: 28.6 bits;  conditional E-value: 1.1e-09
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 a+  +++++++l++y++A+e + k++e++P++
  EFC37724.1 227 AHQHRAAVLYHLKEYEQAIESFTKVIEHDPKD 258
                 67789*************************86 PP

  == domain 7  score: 15.1 bits;  conditional E-value: 2e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 al+n+G++y   g++ + + ++++  ++nP++
  EFC37724.1 261 ALFNRGMCYKFVGELAKSVIDFNQTTKVNPEF 292
                 89****************************86 PP

  == domain 8  score: 16.4 bits;  conditional E-value: 7.7e-06
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALeln 31 
                 +++ +G+ + k +ky+eA++++  A++ +
  EFC37724.1 344 IYFERGVQLVKDEKYQEAIDDFTSAIKKD 372
                 6999**********************987 PP

  == domain 9  score: 14.2 bits;  conditional E-value: 3.9e-05
                 HHHHHHHHHHHH.TT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayfk.lgkydeAleyyekALelnPnn 34 
                 +a++n++n+y++ l+k+++Al + ek+ el++++
  EFC37724.1 377 DAYFNRANVYRRfLKKPEKALSDAEKVCELDETD 410
                 8*********877******************975 PP

  == domain 10  score: 11.9 bits;  conditional E-value: 0.00021
                 HHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   8 GnayfklgkydeAleyyekALelnPnn 34 
                 +++++ l k ++A + +e++L+  P++
  EFC37724.1 418 AMCLYDLDKVEDAKKQFERVLKTKPDH 444
                 89***********************96 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.0   0.00019      0.14       2      26 ..       6      30 ..       5      31 .. 0.93
   2 !   12.2   0.0   0.00021      0.15       2      30 ..      57      85 ..      56      89 .. 0.92
   3 !   11.5   0.0   0.00036      0.27       3      33 ..     105     135 ..     103     136 .. 0.92
   4 !   14.1   0.1     5e-05     0.037       2      30 ..     145     173 ..     144     176 .. 0.92
   5 ?   -0.5   0.0       2.5   1.8e+03       4      33 ..     194     223 ..     192     224 .. 0.65
   6 !   25.4   0.0   1.2e-08     9e-06       3      34 .]     227     258 ..     226     258 .. 0.95
   7 !   10.9   0.0   0.00054      0.41       3      33 ..     261     291 ..     259     292 .. 0.94
   8 !   14.9   0.0   2.9e-05     0.021       3      31 ..     344     372 ..     342     375 .. 0.92
   9 !   12.0   0.0   0.00023      0.17       2      34 .]     377     410 ..     376     410 .. 0.88
  10 !   16.2   0.0   1.1e-05    0.0079       5      34 .]     415     444 ..     411     444 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00019
       TPR_2  2 ealynlGlayyklgdyeeAleafek 26
                +a+  +Glay +l +++eA+++fe+
  EFC37724.1  6 KAHLSRGLAYSNLSKHQEAIQDFEQ 30
                78999*******************8 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00021
       TPR_2  2 ealynlGlayyklgdyeeAleafekAlel 30
                + +y  G + + l+++e  l+ ++kA++l
  EFC37724.1 57 KSWYLKGVSERSLKNHENSLKSLDKAIKL 85
                68**************************9 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 0.00036
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPn 33 
                 +++ +Gl+   +++ye+  + f+k ++l+P+
  EFC37724.1 105 YYMTRGLIFNDQKNYEKSTKNFRKFIKLCPE 135
                 78899999999*******************7 PP

  == domain 4  score: 14.1 bits;  conditional E-value: 5e-05
       TPR_2   2 ealynlGlayyklgdyeeAleafekAlel 30 
                  a++nlG  ++kl++ +eA ea+ +A+++
  EFC37724.1 145 IANHNLGIGLEKLDKEDEAFEAYSEAISH 173
                 5899**********************986 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 2.5
       TPR_2   4 lynlGlayyklgdyeeAleafekAleldPn 33 
                 +y++Gl+ +k+    +++++++ +l+++Pn
  EFC37724.1 194 YYYRGLLSEKKESSMKCIADYDFVLRYNPN 223
                 788887777766555666666666777777 PP

  == domain 6  score: 25.4 bits;  conditional E-value: 1.2e-08
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPnn 34 
                 a+  ++ ++y+l++ye+A+e f k++e+dP++
  EFC37724.1 227 AHQHRAAVLYHLKEYEQAIESFTKVIEHDPKD 258
                 7889**************************86 PP

  == domain 7  score: 10.9 bits;  conditional E-value: 0.00054
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPn 33 
                 al+n+G++y   g++++ + +f++  + +P+
  EFC37724.1 261 ALFNRGMCYKFVGELAKSVIDFNQTTKVNPE 291
                 8**************************9997 PP

  == domain 8  score: 14.9 bits;  conditional E-value: 2.9e-05
       TPR_2   3 alynlGlayyklgdyeeAleafekAleld 31 
                 +++++G  + k  +y+eA+++f  A++ d
  EFC37724.1 344 IYFERGVQLVKDEKYQEAIDDFTSAIKKD 372
                 79************************988 PP

  == domain 9  score: 12.0 bits;  conditional E-value: 0.00023
       TPR_2   2 ealynlGlayyk.lgdyeeAleafekAleldPnn 34 
                 +a++n++++y++ l+++e+Al + ek+ eld+++
  EFC37724.1 377 DAYFNRANVYRRfLKKPEKALSDAEKVCELDETD 410
                 79********9945556**************986 PP

  == domain 10  score: 16.2 bits;  conditional E-value: 1.1e-05
       TPR_2   5 ynlGlayyklgdyeeAleafekAleldPnn 34 
                 ++ ++++y l++ e+A++ fe++l+  P++
  EFC37724.1 415 MEVAMCLYDLDKVEDAKKQFERVLKTKPDH 444
                 6779*********************99986 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   1.6e-05     0.012       2      33 ..       6      37 ..       5      38 .. 0.90
   2 !   15.6   0.1   1.8e-05     0.013       2      30 ..      57      85 ..      56      89 .. 0.95
   3 !   14.6   0.0   3.7e-05     0.027       3      33 ..     105     135 ..     103     136 .. 0.94
   4 ?    5.4   0.1     0.034        26       5      29 ..     148     172 ..     146     172 .. 0.84
   5 ?   -1.4   0.1       5.2   3.9e+03       4      33 ..     194     223 ..     191     224 .. 0.64
   6 !   14.9   0.0     3e-05     0.023       3      34 .]     227     258 ..     225     258 .. 0.87
   7 !    9.8   0.0    0.0014         1       3      33 ..     261     291 ..     259     292 .. 0.93
   8 ?    1.9   0.0      0.45   3.4e+02       4      29 ..     345     370 ..     343     373 .. 0.79
   9 !   16.7   0.0   8.1e-06    0.0061       2      33 ..     377     409 ..     376     410 .. 0.95
  10 !    9.8   0.0    0.0013      0.99       7      34 .]     417     444 ..     411     444 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.6e-05
                CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8  2 eayynlgsiylklgdyeeAkeyyekaleldpd 33
                +a++  g++y++l +++eA++ +e++ +l ++
  EFC37724.1  6 KAHLSRGLAYSNLSKHQEAIQDFEQVDSLTEK 37
                688899********************999776 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 1.8e-05
                CHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8  2 eayynlgsiylklgdyeeAkeyyekalel 30
                +++y++g   ++l+++e++ +++ ka++l
  EFC37724.1 57 KSWYLKGVSERSLKNHENSLKSLDKAIKL 85
                79*************************98 PP

  == domain 3  score: 14.6 bits;  conditional E-value: 3.7e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 +y+  g+i  ++++ye++ + ++k ++l p+
  EFC37724.1 105 YYMTRGLIFNDQKNYEKSTKNFRKFIKLCPE 135
                 799*************************996 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.034
                 HHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekale 29 
                 +nlg  ++kl + +eA e+y +a++
  EFC37724.1 148 HNLGIGLEKLDKEDEAFEAYSEAIS 172
                 566666899**************96 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 5.2
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekaleldpd 33 
                 yy  g++ +k++   + ++ y  +l+++p+
  EFC37724.1 194 YYYRGLLSEKKESSMKCIADYDFVLRYNPN 223
                 666666666777666777777777777776 PP

  == domain 6  score: 14.9 bits;  conditional E-value: 3e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpdn 34 
                 a+++ + ++  l++ye+A+e++ k++e dp++
  EFC37724.1 227 AHQHRAAVLYHLKEYEQAIESFTKVIEHDPKD 258
                 66777888999****************99985 PP

  == domain 7  score: 9.8 bits;  conditional E-value: 0.0014
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 a++n g++y+  g++ +++  +++ ++ +p+
  EFC37724.1 261 ALFNRGMCYKFVGELAKSVIDFNQTTKVNPE 291
                 89**********************9999996 PP

  == domain 8  score: 1.9 bits;  conditional E-value: 0.45
                 HHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekale 29 
                 y+  g  + k ++y+eA+  +  a++
  EFC37724.1 345 YFERGVQLVKDEKYQEAIDDFTSAIK 370
                 5555666677789********99987 PP

  == domain 9  score: 16.7 bits;  conditional E-value: 8.1e-06
                 CHHHHHHHHH.HHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiy.lklgdyeeAkeyyekaleldpd 33 
                 +ay+n +++y + l++ e+A +  ek++eld++
  EFC37724.1 377 DAYFNRANVYrRFLKKPEKALSDAEKVCELDET 409
                 79*****************************86 PP

  == domain 10  score: 9.8 bits;  conditional E-value: 0.0013
                 HHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   7 lgsiylklgdyeeAkeyyekaleldpdn 34 
                  ++++ +l + e Ak+ +e++l+ +pd+
  EFC37724.1 417 VAMCLYDLDKVEDAKKQFERVLKTKPDH 444
                 689999********************96 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.052        39      50      70 ..      10      30 ..       5      37 .. 0.64
   2 ?    6.3   0.0     0.016        12       5      35 ..      58      88 ..      55      92 .. 0.86
   3 !   19.3   0.0   1.4e-06     0.001       8      73 ..     108     172 ..     102     176 .. 0.92
   4 !   18.0   0.0   3.5e-06    0.0026       8      73 ..     230     287 ..     221     291 .. 0.85
   5 !   10.2   0.0   0.00097      0.72      10      76 ..     349     408 ..     340     409 .. 0.70
   6 ?    5.2   0.0     0.035        26       8      41 ..     416     444 ..     410     454 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.052
      TPR_12 50 nLgrlyralgryeeAlellee 70
                  g +y+ l +++eA++ +e+
  EFC37724.1 10 SRGLAYSNLSKHQEAIQDFEQ 30
                455666666666666666665 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.016
      TPR_12  5 alnnlaavlrrlgrydeAlellekaleiarr 35
                +++  ++ +r l++++ +l+ l+ka+ + ++
  EFC37724.1 58 SWYLKGVSERSLKNHENSLKSLDKAIKLGKE 88
                56789999*****************998755 PP

  == domain 3  score: 19.3 bits;  conditional E-value: 1.4e-06
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeala 73 
                  ++++ + +++y+++ ++++k + ++    G ++ ++ ++ +nLg+ +++l++ +eA e++ ea+ 
  EFC37724.1 108 TRGLIFNDQKNYEKSTKNFRKFIKLC-PEEGNNNMELFIANHNLGIGLEKLDKEDEAFEAYSEAIS 172
                 68999*********************.55699*******************************986 PP

  == domain 4  score: 18.0 bits;  conditional E-value: 3.5e-06
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeala 73 
                 ++aavl++l++y++A+e + k++e       p      t+l+n g++y   g++++ +  ++++++
  EFC37724.1 230 HRAAVLYHLKEYEQAIESFTKVIEHD-----P---KDFTALFNRGMCYKFVGELAKSVIDFNQTTK 287
                 69********************6666.....5...4699*********999***999999999876 PP

  == domain 5  score: 10.2 bits;  conditional E-value: 0.00097
      TPR_12  10 aavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyr.algryeeAlelleealaiae 76 
                 ++ l + ++y+eA++ +  a   + +  G+     + +++n + +yr  l+++e+Al+  e++ +++e
  EFC37724.1 349 GVQLVKDEKYQEAIDDFTSA---I-KKDGK----FVDAYFNRANVYRrFLKKPEKALSDAEKVCELDE 408
                 55566666777777777777...2.22232....4679999999996266999999999999999876 PP

  == domain 6  score: 5.2 bits;  conditional E-value: 0.035
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdh 41 
                 ++a++l+ l + ++A + +e++l        pdh
  EFC37724.1 416 EVAMCLYDLDKVEDAKKQFERVLKTK-----PDH 444
                 68999999999999999999998765.....555 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0      0.15   1.2e+02      14      34 .]       6      26 ..       5      26 .. 0.91
   2 ?   -1.8   0.0       7.4   5.6e+03      13      29 ..      56      72 ..      54      77 .. 0.72
   3 ?   -1.1   0.0       4.4   3.3e+03       2      12 ..     126     136 ..     125     163 .. 0.70
   4 ?    1.7   0.0      0.56   4.2e+02      13      33 ..     191     211 ..     185     212 .. 0.84
   5 !   10.4   0.1   0.00091      0.68       6      34 .]     218     246 ..     217     246 .. 0.95
   6 !   22.1   0.0   1.7e-07   0.00013       2      31 ..     248     277 ..     247     279 .. 0.92
   7 ?    0.0   0.0       1.9   1.4e+03       6      27 ..     286     307 ..     282     313 .. 0.79
   8 ?    1.2   0.0      0.79   5.9e+02      14      33 ..     343     362 ..     331     363 .. 0.85
   9 !   15.0   0.0   3.3e-05     0.024       3      33 ..     366     397 ..     364     398 .. 0.86
  10 ?    3.6   0.0      0.14   1.1e+02       3      33 ..     401     431 ..     399     432 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.15
      TPR_17 14 daynnLAelllknGdlmtArq 34
                +a+  ++ +++++ ++++A+q
  EFC37724.1  6 KAHLSRGLAYSNLSKHQEAIQ 26
                68999**************98 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 7.4
      TPR_17 13 adaynnLAelllknGdl 29
                +++++++++  ++++++
  EFC37724.1 56 VKSWYLKGVSERSLKNH 72
                67899999887766655 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 4.4
      TPR_17   2 ylkaleldPnn 12 
                 ++k+++l+P  
  EFC37724.1 126 FRKFIKLCPEE 136
                 67888888865 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.56
      TPR_17  13 adaynnLAelllknGdlmtAr 33 
                  d y++++ l +k+  +m+++
  EFC37724.1 191 LDTYYYRGLLSEKKESSMKCI 211
                 589*********999999987 PP

  == domain 5  score: 10.4 bits;  conditional E-value: 0.00091
      TPR_17   6 leldPnnadaynnLAelllknGdlmtArq 34 
                 l+++Pn+  a++ +A +l++++++++A++
  EFC37724.1 218 LRYNPNHLHAHQHRAAVLYHLKEYEQAIE 246
                 899************************86 PP

  == domain 6  score: 22.1 bits;  conditional E-value: 1.7e-07
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlmt 31 
                 ++k++e+dP+++ a++n++ +++  G+l++
  EFC37724.1 248 FTKVIEHDPKDFTALFNRGMCYKFVGELAK 277
                 78**********************999875 PP

  == domain 7  score: 0.0 bits;  conditional E-value: 1.9
      TPR_17   6 leldPnnadaynnLAelllknG 27 
                  + +P  ++ay +L ++l k+ 
  EFC37724.1 286 TKVNPEFFKAYSELVRVLIKLD 307
                 5789*******99988887765 PP

  == domain 8  score: 1.2 bits;  conditional E-value: 0.79
      TPR_17  14 daynnLAelllknGdlmtAr 33 
                   y+++++ l k  ++++A+
  EFC37724.1 343 AIYFERGVQLVKDEKYQEAI 362
                 689***************97 PP

  == domain 9  score: 15.0 bits;  conditional E-value: 3.3e-05
      TPR_17   3 lkaleldPnnadaynnLAelll.knGdlmtAr 33 
                 + a+++d + +day+n+A++++  ++++++A+
  EFC37724.1 366 TSAIKKDGKFVDAYFNRANVYRrFLKKPEKAL 397
                 569******************75778888875 PP

  == domain 10  score: 3.6 bits;  conditional E-value: 0.14
      TPR_17   3 lkaleldPnnadaynnLAelllknGdlmtAr 33 
                 +k+ eld +++d + + A +l+ + + ++A+
  EFC37724.1 401 EKVCELDETDVDGMMEVAMCLYDLDKVEDAK 431
                 8999*******************99999997 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.062        46       2      26 ..       7      31 ..       6      33 .. 0.90
   2 ?    2.7   0.0      0.32   2.4e+02       3      28 ..      59      84 ..      57      85 .. 0.91
   3 ?    1.8   0.0      0.61   4.5e+02       7      31 ..     110     134 ..     106     135 .. 0.84
   4 ?    2.2   0.0      0.47   3.5e+02       6      30 ..     150     174 ..     146     176 .. 0.81
   5 ?   -0.9   0.0       4.6   3.5e+03       2      32 ..     193     223 ..     192     224 .. 0.74
   6 !   11.6   0.0   0.00047      0.35       5      32 ..     231     257 ..     227     258 .. 0.81
   7 ?    6.7   0.0     0.017        12       2      28 ..     261     287 ..     260     291 .. 0.80
   8 ?    0.8   0.0       1.3   9.7e+02       6      29 ..     348     371 ..     341     373 .. 0.69
   9 !    8.8   0.0    0.0035       2.6       1      26 [.     377     403 ..     377     406 .. 0.92
  10 !   12.7   0.0   0.00021      0.16       2      32 ..     413     443 ..     412     444 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.062
                HHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6  2 AlyklalsyrklgdtdkAlealerl 26
                A + ++l+y +l ++++A++ +e++
  EFC37724.1  7 AHLSRGLAYSNLSKHQEAIQDFEQV 31
                67789******99**********97 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.32
                HHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6  3 lyklalsyrklgdtdkAlealerlik 28
                 y+ + s r+l++++++l+ l++ ik
  EFC37724.1 59 WYLKGVSERSLKNHENSLKSLDKAIK 84
                69999*****99**********9997 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.61
                 HHHHHHHHHHHHHHHHHHHHHHH-T CS
       TPR_6   7 alsyrklgdtdkAlealerlikeYP 31 
                 +l +  +++++k+ + ++++ik  P
  EFC37724.1 110 GLIFNDQKNYEKSTKNFRKFIKLCP 134
                 66777799*************9877 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.47
                 HHHHHHHHHHHHHHHHHHHHHHHH- CS
       TPR_6   6 lalsyrklgdtdkAlealerlikeY 30 
                 l+  ++kl++ d+A ea+ + i+ +
  EFC37724.1 150 LGIGLEKLDKEDEAFEAYSEAISHF 174
                 666678898999******9999765 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 4.6
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerlikeYPd 32 
                  +y+++l+ +k   + k ++ ++ +++  P+
  EFC37724.1 193 TYYYRGLLSEKKESSMKCIADYDFVLRYNPN 223
                 5899998888862555888888888888887 PP

  == domain 6  score: 11.6 bits;  conditional E-value: 0.00047
                 HHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   5 klalsyrklgdtdkAlealerlikeYPd 32 
                 ++a +y  l+++++A+e + ++i+  P+
  EFC37724.1 231 RAAVLYH-LKEYEQAIESFTKVIEHDPK 257
                 4555555.66**************9986 PP

  == domain 7  score: 6.7 bits;  conditional E-value: 0.017
                 HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerlik 28 
                 Al++++++y+  g+ +k++  +++  k
  EFC37724.1 261 ALFNRGMCYKFVGELAKSVIDFNQTTK 287
                 9*********96699999888877655 PP

  == domain 8  score: 0.8 bits;  conditional E-value: 1.3
                 HHHHHHH.HHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrk.lgdtdkAlealerlike 29 
                 ++  + k   ++++A++ + + ik+
  EFC37724.1 348 RGVQLVKdE-KYQEAIDDFTSAIKK 371
                 444444433.999***999999986 PP

  == domain 9  score: 8.8 bits;  conditional E-value: 0.0035
                 HHHHHHHHHHHH.HHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrk.lgdtdkAlealerl 26 
                 dA++++a  yr+ l++++kAl   e++
  EFC37724.1 377 DAYFNRANVYRRfLKKPEKALSDAEKV 403
                 8*******************9988887 PP

  == domain 10  score: 12.7 bits;  conditional E-value: 0.00021
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerlikeYPd 32 
                  ++  a++++ l++ ++A++ +er++k  Pd
  EFC37724.1 413 GMMEVAMCLYDLDKVEDAKKQFERVLKTKPD 443
                 68899*******9*************98777 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.065        48      33      54 ..       9      30 ..       5      37 .. 0.90
   2 ?    5.2   0.0     0.031        23      32      62 ..     106     136 ..     100     141 .. 0.91
   3 !   26.3   0.0     8e-09     6e-06       8      65 ..     204     261 ..     198     265 .. 0.92
   4 ?    4.5   0.0     0.051        38      25      60 ..     255     290 ..     250     304 .. 0.88
   5 !    7.7   0.0    0.0051       3.8      32      64 ..     345     377 ..     343     385 .. 0.86
   6 !   15.1   0.0   2.6e-05      0.02      10      67 ..     392     449 ..     390     455 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.065
       TPR_9 33 rdRGlllaqlGclsaAladLea 54
                + RGl++  l   ++A++d+e+
  EFC37724.1  9 LSRGLAYSNLSKHQEAIQDFEQ 30
                67******************97 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.031
       TPR_9  32 rrdRGlllaqlGclsaAladLeaylalapda 62 
                 ++ RGl+   + ++++  + +  ++ l+p+ 
  EFC37724.1 106 YMTRGLIFNDQKNYEKSTKNFRKFIKLCPEE 136
                 578**************************86 PP

  == domain 3  score: 26.3 bits;  conditional E-value: 8e-09
       TPR_9   8 eedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapda 65 
                 +e + +++a ++ +l  +P++ + +  R+ +l++l  +++A++ +   ++++p++ +a
  EFC37724.1 204 KESSMKCIADYDFVLRYNPNHLHAHQHRAAVLYHLKEYEQAIESFTKVIEHDPKDFTA 261
                 56777899*********************************************98665 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.051
       TPR_9  25 aPddpeerrdRGlllaqlGclsaAladLeaylalap 60 
                 +P+d   ++ RG+++  +G l++ + d+++   ++p
  EFC37724.1 255 DPKDFTALFNRGMCYKFVGELAKSVIDFNQTTKVNP 290
                 899*************************99888877 PP

  == domain 5  score: 7.7 bits;  conditional E-value: 0.0051
       TPR_9  32 rrdRGlllaqlGclsaAladLeaylalapdapd 64 
                 +++RG+ l++ + +++A++d+  ++ ++++  d
  EFC37724.1 345 YFERGVQLVKDEKYQEAIDDFTSAIKKDGKFVD 377
                 689********************9998876555 PP

  == domain 6  score: 15.1 bits;  conditional E-value: 2.6e-05
       TPR_9  10 dweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaea 67 
                 + e+al  +e +  l+  d++  ++ +++l+ l+ ++ A + +e+ l   pd + a++
  EFC37724.1 392 KPEKALSDAEKVCELDETDVDGMMEVAMCLYDLDKVEDAKKQFERVLKTKPDHEPARR 449
                 5799*******************************************99997776665 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0    0.0062       4.7      35      58 ..       6      29 ..       4      33 .. 0.87
   2 ?    1.3   0.0      0.75   5.6e+02      35      62 ..      57      84 ..      41      89 .. 0.84
   3 !   18.7   0.0   2.7e-06     0.002      18      67 ..     212     258 ..     211     259 .. 0.94
   4 !   17.1   0.0   8.8e-06    0.0066       6      56 ..     234     282 ..     231     291 .. 0.86
   5 !   16.5   0.0   1.3e-05    0.0099       7      54 ..     352     397 ..     346     410 .. 0.83
   6 !    7.9   0.0    0.0065       4.9       7      38 ..     421     449 ..     415     451 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0062
      TPR_16 35 eAllllgdaalrqgrlaeAaalyr 58
                 A+l +g+a+  ++ ++eA++ ++
  EFC37724.1  6 KAHLSRGLAYSNLSKHQEAIQDFE 29
                69******************6665 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.75
      TPR_16 35 eAllllgdaalrqgrlaeAaalyraalr 62
                 +++l+g++   +++++  +  +++a++
  EFC37724.1 57 KSWYLKGVSERSLKNHENSLKSLDKAIK 84
                6899999999999999999977777765 PP

  == domain 3  score: 18.7 bits;  conditional E-value: 2.7e-06
      TPR_16  18 aaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapda 67 
                 a ++ +l+++   P + +A+ +++ +++++++++ A++ + + ++++p++
  EFC37724.1 212 ADYDFVLRYN---PNHLHAHQHRAAVLYHLKEYEQAIESFTKVIEHDPKD 258
                 678899****...***********************************86 PP

  == domain 4  score: 17.1 bits;  conditional E-value: 8.8e-06
      TPR_16   6 aalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAa.al 56 
                  ++ +++y++A++ ++ +++ d   P +  Al+++g ++   g+la+ + ++
  EFC37724.1 234 VLYHLKEYEQAIESFTKVIEHD---PKDFTALFNRGMCYKFVGELAKSViDF 282
                 5677899***************...**************9889998887554 PP

  == domain 5  score: 16.5 bits;  conditional E-value: 1.3e-05
      TPR_16   7 alragdyddAaaaleaalkrdpssPdaaeAllllgdaalrq.grlaeAa 54 
                 +++  +y++A+  ++ a+k+d      ++A++++++++ r+ +  ++A+
  EFC37724.1 352 LVKDEKYQEAIDDFTSAIKKD---GKFVDAYFNRANVYRRFlKKPEKAL 397
                 67889****************...89999*********99886666665 PP

  == domain 6  score: 7.9 bits;  conditional E-value: 0.0065
      TPR_16   7 alragdyddAaaaleaalkrdpssPdaaeAll 38 
                 ++++ + +dA +++e++lk     Pd+  A+ 
  EFC37724.1 421 LYDLDKVEDAKKQFERVLKTK---PDHEPARR 449
                 789999**************9...88766655 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.69   5.2e+02      29      40 ..       6      17 ..       5      19 .. 0.84
   2 ?    0.9   0.1       0.5   3.7e+02       1      25 [.      12      36 ..      12      40 .. 0.76
   3 ?    3.9   0.0     0.057        43       4      23 ..      66      85 ..      63      89 .. 0.86
   4 ?    6.1   0.0     0.012       8.8       1      26 [.     110     135 ..     110     136 .. 0.95
   5 ?    1.2   0.1       0.4     3e+02      11      21 ..     161     171 ..     157     172 .. 0.90
   6 ?    0.7   0.1      0.56   4.2e+02      14      39 ..     211     236 ..     210     239 .. 0.90
   7 !   21.8   0.0   1.5e-07   0.00011       3      35 ..     234     266 ..     232     270 .. 0.92
   8 ?    2.0   0.0      0.23   1.7e+02       8      34 ..     273     299 ..     272     311 .. 0.90
   9 !   20.8   0.1     3e-07   0.00022       5      38 ..     353     386 ..     342     388 .. 0.92
  10 ?   -2.1   0.0       4.2   3.1e+03      18      29 ..     401     412 ..     394     413 .. 0.80
  11 ?    1.0   0.0      0.47   3.5e+02       4      26 ..     421     443 ..     421     448 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.69
      TPR_11 29 eayynLGlayyk 40
                 a++ +Glay +
  EFC37724.1  6 KAHLSRGLAYSN 17
                59********76 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.5
      TPR_11  1 GdayyeqGkyeeAieaYkkAlkldP 25
                G ay  + k  eAi+++++   l++
  EFC37724.1 12 GLAYSNLSKHQEAIQDFEQVDSLTE 36
                66777788999*****999766555 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.057
      TPR_11  4 yyeqGkyeeAieaYkkAlkl 23
                 +++ + e++++++ kA+kl
  EFC37724.1 66 ERSLKNHENSLKSLDKAIKL 85
                5788899************9 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.012
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPd 26 
                 G ++ +q +ye++ ++++k +kl+P+
  EFC37724.1 110 GLIFNDQKNYEKSTKNFRKFIKLCPE 135
                 889*********************96 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.4
      TPR_11  11 eeAieaYkkAl 21 
                 +eA eaY++A+
  EFC37724.1 161 DEAFEAYSEAI 171
                 79********9 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.56
      TPR_11  14 ieaYkkAlkldPdnaeayynLGlayy 39 
                 i++Y   l+++P+   a+ ++++++y
  EFC37724.1 211 IADYDFVLRYNPNHLHAHQHRAAVLY 236
                 7889999***********99999998 PP

  == domain 7  score: 21.8 bits;  conditional E-value: 1.5e-07
      TPR_11   3 ayyeqGkyeeAieaYkkAlkldPdnaeayynLG 35 
                 ++y + +ye+Aie++ k ++ dP++ +a++n+G
  EFC37724.1 234 VLYHLKEYEQAIESFTKVIEHDPKDFTALFNRG 266
                 578899**************************9 PP

  == domain 8  score: 2.0 bits;  conditional E-value: 0.23
      TPR_11   8 GkyeeAieaYkkAlkldPdnaeayynL 34 
                 G++ +++ ++++  k +P++  ay++L
  EFC37724.1 273 GELAKSVIDFNQTTKVNPEFFKAYSEL 299
                 78888888999999**********987 PP

  == domain 9  score: 20.8 bits;  conditional E-value: 3e-07
      TPR_11   5 yeqGkyeeAieaYkkAlkldPdnaeayynLGlay 38 
                 ++  ky eAi ++  A+k d ++++ay+n++++y
  EFC37724.1 353 VKDEKYQEAIDDFTSAIKKDGKFVDAYFNRANVY 386
                 56679****************************9 PP

  == domain 10  score: -2.1 bits;  conditional E-value: 4.2
      TPR_11  18 kkAlkldPdnae 29 
                 +k ++ld+++++
  EFC37724.1 401 EKVCELDETDVD 412
                 6899***99987 PP

  == domain 11  score: 1.0 bits;  conditional E-value: 0.47
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPd 26 
                 +y++ k e+A +++++ lk +Pd
  EFC37724.1 421 LYDLDKVEDAKKQFERVLKTKPD 443
                 689999*************9998 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0      0.12        89       2      30 ..       6      34 ..       5      40 .. 0.87
   2 ?    1.9   0.0      0.73   5.4e+02       4      32 ..      59      87 ..      56      94 .. 0.84
   3 ?    0.9   0.0       1.5   1.1e+03       4      34 ..     106     136 ..     103     144 .. 0.87
   4 ?    4.9   0.0     0.076        57       7      32 ..     150     175 ..     146     180 .. 0.88
   5 !   18.3   0.0   3.7e-06    0.0028       3      40 ..     227     264 ..     225     267 .. 0.92
   6 ?   -0.5   0.0       4.3   3.2e+03       2      29 ..     294     323 ..     293     327 .. 0.69
   7 ?    3.4   0.0      0.24   1.8e+02       6      42 ..     347     383 ..     343     385 .. 0.85
   8 ?    1.5   0.0      0.96   7.2e+02       2      35 ..     377     411 ..     376     418 .. 0.83
   9 !   11.2   0.0   0.00072      0.54      11      41 ..     421     451 ..     411     451 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.12
      TPR_14  2 eallalaeallalGdpdeAiallrralal 30
                +a+l ++ a+ +l +++eAi+ ++++ +l
  EFC37724.1  6 KAHLSRGLAYSNLSKHQEAIQDFEQVDSL 34
                68999****************99998665 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.73
      TPR_14  4 llalaeallalGdpdeAiallrralalaP 32
                +++ +  ++ l +++ +++ l++a++l+ 
  EFC37724.1 59 WYLKGVSERSLKNHENSLKSLDKAIKLGK 87
                777788889999*************9876 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 1.5
      TPR_14   4 llalaeallalGdpdeAiallrralalaPdd 34 
                 ++ ++ ++  + +++++ + +r+ ++l+P++
  EFC37724.1 106 YMTRGLIFNDQKNYEKSTKNFRKFIKLCPEE 136
                 6678889999*******************85 PP

  == domain 4  score: 4.9 bits;  conditional E-value: 0.076
      TPR_14   7 laeallalGdpdeAiallrralalaP 32 
                 l+  l+ l++ deA +++ +a++++ 
  EFC37724.1 150 LGIGLEKLDKEDEAFEAYSEAISHFG 175
                 67789999999***********9986 PP

  == domain 5  score: 18.3 bits;  conditional E-value: 3.7e-06
      TPR_14   3 allalaeallalGdpdeAiallrralalaPddaeawll 40 
                 a++ +a++l++l ++++Ai+ + ++++++P+d +a++ 
  EFC37724.1 227 AHQHRAAVLYHLKEYEQAIESFTKVIEHDPKDFTALFN 264
                 7899****************************999875 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 4.3
      TPR_14   2 eallalaeallal..GdpdeAiallrrala 29 
                 +a+ +l+++l  l   dp++ i l+ + ++
  EFC37724.1 294 KAYSELVRVLIKLdeKDPQRLIPLYTKSIE 323
                 578888888876511568888888877665 PP

  == domain 7  score: 3.4 bits;  conditional E-value: 0.24
      TPR_14   6 alaeallalGdpdeAiallrralalaPddaeawllla 42 
                 +++  l   ++++eAi+ +  a++++ ++ +a++  a
  EFC37724.1 347 ERGVQLVKDEKYQEAIDDFTSAIKKDGKFVDAYFNRA 383
                 667778888999*****************99998776 PP

  == domain 8  score: 1.5 bits;  conditional E-value: 0.96
      TPR_14   2 eallalaealla.lGdpdeAiallrralalaPdda 35 
                 +a+  +a ++++ l +p++A+  ++++++l+ +d 
  EFC37724.1 377 DAYFNRANVYRRfLKKPEKALSDAEKVCELDETDV 411
                 6777899999987899**99999999999998876 PP

  == domain 9  score: 11.2 bits;  conditional E-value: 0.00072
      TPR_14  11 llalGdpdeAiallrralalaPddaeawlll 41 
                 l+ l++ ++A + ++r+l++ Pd++ a+++l
  EFC37724.1 421 LYDLDKVEDAKKQFERVLKTKPDHEPARRYL 451
                 67788999*******************9987 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       5.5   4.1e+03       6      17 ..      20      31 ..      18      38 .. 0.79
   2 ?   -1.4   0.0       4.7   3.5e+03       6      21 ..     166     181 ..     162     195 .. 0.75
   3 !   16.0   0.0   1.7e-05     0.013      17      58 ..     217     258 ..     211     263 .. 0.91
   4 ?   -0.7   0.0       2.8   2.1e+03      19      42 ..     287     310 ..     282     311 .. 0.82
   5 !    9.9   0.0    0.0014         1       1      35 [.     352     386 ..     352     388 .. 0.93
   6 !   14.1   0.0   6.6e-05     0.049       6      59 ..     392     446 ..     390     451 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 5.5
      TPR_19  6 dyaeAlalleqa 17
                +++eA++ +eq+
  EFC37724.1 20 KHQEAIQDFEQV 31
                689999999997 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 4.7
      TPR_19   6 dyaeAlalleqalqed 21 
                  y eA++++ ++ +++
  EFC37724.1 166 AYSEAISHFGKVSDKE 181
                 5889999999985554 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 1.7e-05
      TPR_19  17 alqedpknaearllLAeallalgqldeAealLdalpeedpdd 58 
                 +l ++p+++ a    A +l+ l+++++A++   ++ e+dp+d
  EFC37724.1 217 VLRYNPNHLHAHQHRAAVLYHLKEYEQAIESFTKVIEHDPKD 258
                 7899************************************97 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 2.8
      TPR_19  19 qedpknaearllLAeallalgqld 42 
                 + +p+   a   L+++l++l + d
  EFC37724.1 287 KVNPEFFKAYSELVRVLIKLDEKD 310
                 568999999999*******98866 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.0014
      TPR_19   1 llaegdyaeAlalleqalqedpknaearllLAeal 35 
                 l+++++y+eA++ +++a+++d k  +a  + A+++
  EFC37724.1 352 LVKDEKYQEAIDDFTSAIKKDGKFVDAYFNRANVY 386
                 57899************************999998 PP

  == domain 6  score: 14.1 bits;  conditional E-value: 6.6e-05
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpdd.a 59 
                 +++ Al+  e++ + d  + +  +  A +l+ l  +++A++  +++++ +pd+ +
  EFC37724.1 392 KPEKALSDAEKVCELDETDVDGMMEVAMCLYDLDKVEDAKKQFERVLKTKPDHeP 446
                 577899999999999999**********************************734 PP

>> TPR_20  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.0    0.0009      0.67      16      54 ..     219     257 ..     208     267 .. 0.90
   2 !    7.1   0.0    0.0089       6.6      23      55 ..     343     375 ..     329     391 .. 0.85
   3 !    7.4   0.0    0.0075       5.6       6      55 ..     395     444 ..     390     452 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.0009
      TPR_20  16 aanpddldarldlAlallaagryeeAleqLleilkrdrk 54 
                   np+ l a+   A +l++ ++ye+A+e + +++++d k
  EFC37724.1 219 RYNPNHLHAHQHRAAVLYHLKEYEQAIESFTKVIEHDPK 257
                 569********************************9976 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0089
      TPR_20  23 darldlAlallaagryeeAleqLleilkrdrkw 55 
                 ++ ++   +l++ ++y+eA++ + + +k+d k+
  EFC37724.1 343 AIYFERGVQLVKDEKYQEAIDDFTSAIKKDGKF 375
                 56789999**********************988 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0075
      TPR_20   6 pelaeleaalaanpddldarldlAlallaagryeeAleqLleilkrdrkw 55 
                 + l++ e+ ++ + +d+d ++++A  l+   ++e+A +q+ ++lk++ + 
  EFC37724.1 395 KALSDAEKVCELDETDVDGMMEVAMCLYDLDKVEDAKKQFERVLKTKPDH 444
                 567889999999****************************9999987664 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.1    0.0016       1.2       2      24 ..       8      30 ..       7      47 .. 0.84
   2 ?   -1.3   0.0         4     3e+03      15      28 ..     167     178 ..     165     183 .. 0.80
   3 !    7.3   0.0    0.0073       5.5      12      33 ..     238     257 ..     230     258 .. 0.82
   4 ?    2.5   0.0      0.25   1.9e+02      14      28 ..     310     324 ..     295     336 .. 0.82
   5 ?    1.9   0.0      0.37   2.7e+02      11      31 ..     354     372 ..     341     374 .. 0.84
   6 ?    2.2   0.0       0.3   2.3e+02       1      23 [.     378     401 ..     378     412 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0016
       TPR_7  2 LlnLarlysrlGdyeeAielyeq 24
                +l  + +ys+l +++eAi+ +eq
  EFC37724.1  8 HLSRGLAYSNLSKHQEAIQDFEQ 30
                567799****************9 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 4
       TPR_7  15 yeeAielyeqsLal 28 
                 y+eAi+++ +  + 
  EFC37724.1 167 YSEAISHFGK--VS 178
                 89*****988..55 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0073
       TPR_7  12 lGdyeeAielyeqsLaltkdpe 33 
                 l +ye+Aie +++  +++ dp 
  EFC37724.1 238 LKEYEQAIESFTK--VIEHDPK 257
                 469**********..9998885 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.25
       TPR_7  14 dyeeAielyeqsLal 28 
                 d +++i ly++s++l
  EFC37724.1 310 DPQRLIPLYTKSIEL 324
                 889********8876 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.37
       TPR_7  11 rlGdyeeAielyeqsLaltkd 31 
                 ++ +y+eAi+ ++   a+ kd
  EFC37724.1 354 KDEKYQEAIDDFTS--AIKKD 372
                 6789******9999..87776 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.3
       TPR_7   1 aLlnLarlysr.lGdyeeAielye 23 
                 a++n a++y+r l + e+A++  e
  EFC37724.1 378 AYFNRANVYRRfLKKPEKALSDAE 401
                 799********9999999987555 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0063       4.7       9      28 ..      12      31 ..      10      35 .. 0.94
   2 ?   -1.4   0.0       3.3   2.4e+03      13      33 ..      67      87 ..      63      89 .. 0.81
   3 ?    4.6   0.1     0.043        32       6      29 ..     148     171 ..     146     172 .. 0.92
   4 ?    1.1   0.0      0.53   3.9e+02       9      28 ..     232     251 ..     230     253 .. 0.80
   5 ?    2.1   0.0      0.26     2e+02       7      30 ..     381     405 ..     377     408 .. 0.87
   6 ?    1.5   0.0      0.39   2.9e+02       9      31 ..     418     440 ..     414     441 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0063
      TPR_10  9 analrqrgrydeAealleea 28
                + a++++ +++eA +++e++
  EFC37724.1 12 GLAYSNLSKHQEAIQDFEQV 31
                789***************96 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 3.3
      TPR_10 13 rqrgrydeAealleealairr 33
                r++++++ +++ l++a+ + +
  EFC37724.1 67 RSLKNHENSLKSLDKAIKLGK 87
                788999999999999998755 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.043
      TPR_10   6 nNLanalrqrgrydeAealleeal 29 
                 +NL++ l ++ + deA + + ea+
  EFC37724.1 148 HNLGIGLEKLDKEDEAFEAYSEAI 171
                 9******************99998 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.53
      TPR_10   9 analrqrgrydeAealleea 28 
                 a++l+++++y++A + + ++
  EFC37724.1 232 AAVLYHLKEYEQAIESFTKV 251
                 78999******998866665 PP

  == domain 5  score: 2.1 bits;  conditional E-value: 0.26
      TPR_10   7 NLanal.rqrgrydeAealleeala 30 
                 N an++ r +++ ++A+ ++e++ +
  EFC37724.1 381 NRANVYrRFLKKPEKALSDAEKVCE 405
                 7799999999999*****9999976 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.39
      TPR_10   9 analrqrgrydeAealleealai 31 
                 a+ l+++ + ++A + +e++l +
  EFC37724.1 418 AMCLYDLDKVEDAKKQFERVLKT 440
                 666899**************976 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       3.8   2.8e+03      24      40 ..      69      86 ..      63     100 .. 0.66
   2 !    9.9   0.1     0.001      0.78      15      40 ..     155     181 ..     149     197 .. 0.79
   3 ?    3.0   0.0      0.15   1.1e+02      25      43 ..     239     256 ..     231     269 .. 0.77
   4 ?   -0.9   0.0       2.4   1.8e+03      24      37 ..     315     328 ..     305     339 .. 0.79
   5 ?    5.7   0.0     0.021        16      25      39 ..     356     370 ..     345     387 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 3.8
         MIT 24 lelYkealelLlqalk.e 40
                l++ +++l+ L +a+k  
  EFC37724.1 69 LKNHENSLKSLDKAIKlG 86
                566667777777777632 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.001
         MIT  15 DnagnyeeAlelYkealelLlqalk.e 40 
                 ++  + +eA+e+Y+ea+ ++ ++   e
  EFC37724.1 155 EKLDKEDEAFEAYSEAISHFGKVSDkE 181
                 6667889*************9999722 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.15
         MIT  25 elYkealelLlqalkekne 43 
                 + Y++a+e +++++   ++
  EFC37724.1 239 KEYEQAIESFTKVIE-HDP 256
                 569999999999986.444 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 2.4
         MIT  24 lelYkealelLlqa 37 
                 + lY++++el+  +
  EFC37724.1 315 IPLYTKSIELIEAG 328
                 67999999998765 PP

  == domain 5  score: 5.7 bits;  conditional E-value: 0.021
         MIT  25 elYkealelLlqalk 39 
                 e+Y+ea++ ++ a+k
  EFC37724.1 356 EKYQEAIDDFTSAIK 370
                 567777777777776 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0       1.6   1.2e+03      32      78 ..      14      27 ..       6      39 .. 0.60
   2 ?   -2.4   0.0       7.9   5.9e+03      56      81 ..      56      81 ..      45      82 .. 0.79
   3 ?   -2.6   0.0       9.2   6.9e+03      18      18 ..      96      96 ..      69     132 .. 0.50
   4 !   10.8   1.6   0.00061      0.46       5      81 ..     167     250 ..     165     251 .. 0.72
   5 !   10.5   0.7   0.00073      0.54      20      80 ..     219     249 ..     199     269 .. 0.68
   6 ?    0.7   0.0      0.86   6.4e+02      66      77 ..     351     363 ..     330     368 .. 0.67
   7 !    8.8   0.0    0.0025       1.8      30      80 ..     383     435 ..     369     437 .. 0.82
   8 !    8.6   0.0    0.0029       2.2       8      53 ..     396     442 ..     390     451 .. 0.54

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 1.6
                HHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHHHHHHHTT-HHHHHHH CS
      ANAPC3 32 clylngqykrAyellrkaklnskslgcrylfAqcllkLkkyeeAiaa 78
                ++                                   L+k++eAi+ 
  EFC37724.1 14 AYS---------------------------------NLSKHQEAIQD 27
                444.................................45566666543 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 7.9
                HHHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3 56 lgcrylfAqcllkLkkyeeAiaaLek 81
                 +++yl++ +   Lk++e  ++ L+k
  EFC37724.1 56 VKSWYLKGVSERSLKNHENSLKSLDK 81
                57899999988888888888888876 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 9.2
                H CS
      ANAPC3 18 a 18
                +
  EFC37724.1 96 S 96
                2 PP

  == domain 4  score: 10.8 bits;  conditional E-value: 0.00061
                 HHHHHHHHHHHH.......HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3   5 yknAiflaerll......aaetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaLek 81 
                 y +Ai ++ ++       +a++ s++  y+ +l   + +   +++  ++   + n+++l ++   A +l+ Lk+ye+Ai  + k
  EFC37724.1 167 YSEAISHFGKVSdkekqwKAHSGSLDTYYYRGLLSEKKESSMKCIADYDFVlRYNPNHLHAHQHRAAVLYHLKEYEQAIESFTK 250
                 666666666666665544566666666666677777777777777666666677999999999999999999999999988765 PP

  == domain 5  score: 10.5 bits;  conditional E-value: 0.00073
                 H--HHHHHHHHHHHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHHHHHHHTT-HHHHHHHH- CS
      ANAPC3  20 tespedayllAlclylngqykrAyellrkaklnskslgcrylfAqcllkLkkyeeAiaaLe 80 
                 ++                              n+++l ++   A +l+ Lk+ye+Ai  + 
  EFC37724.1 219 RY------------------------------NPNHLHAHQHRAAVLYHLKEYEQAIESFT 249
                 33..............................55555556666666666666666655543 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.86
                 HH.HTT-HHHHHH CS
      ANAPC3  66 ll.kLkkyeeAia 77 
                 +l k +ky+eAi+
  EFC37724.1 351 QLvKDEKYQEAID 363
                 4426689999986 PP

  == domain 7  score: 8.8 bits;  conditional E-value: 0.0025
                 HHHHHH.TT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH- CS
      ANAPC3  30 Alclyl.ngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaLe 80 
                 A ++ + +++ ++A+  ++k  +l++++    +  A cl++L+k+e+A + +e
  EFC37724.1 383 ANVYRRfLKKPEKALSDAEKVcELDETDVDGMMEVAMCLYDLDKVEDAKKQFE 435
                 55555546789999999999999999999999999************977666 PP

  == domain 8  score: 8.6 bits;  conditional E-value: 0.0029
                 HHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHH CS
      ANAPC3   8 AiflaerllaaetespedayllAlclylngqykrAyellrka.klns 53 
                 A+  ae++++ +  + +  +  A cly + + + A + +++  k+++
  EFC37724.1 396 ALSDAEKVCELDETDVDGMMEVAMCLYDLDKVEDAKKQFERVlKTKP 442
                 33335555555555555555556666666666666666665555555 PP

>> TPR_3  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.1   0.00016      0.12       2      23 ..     223     247 ..     222     250 .. 0.90
   2 ?    0.7   0.1      0.74   5.5e+02      15      22 ..     356     363 ..     354     370 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00016
                 HHHHHH...HHHHHHTT-HHHHHHH CS
       TPR_3   2 dylysy...AaefynkkkyqeArel 23 
                 + l+++   Aa++y  k+y++A+e 
  EFC37724.1 223 NHLHAHqhrAAVLYHLKEYEQAIES 247
                 77999999***************96 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.74
                 T-HHHHHH CS
       TPR_3  15 kkyqeAre 22 
                 +kyqeA++
  EFC37724.1 356 EKYQEAID 363
                 79****98 PP

>> Coatomer_E  Coatomer epsilon subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       2.7     2e+03     244     269 ..      24      49 ..      15      57 .. 0.76
   2 ?   10.8   0.0   0.00032      0.24     196     253 ..     219     277 ..     214     298 .. 0.82
   3 ?    0.9   0.1      0.32   2.4e+02     213     253 ..     389     429 ..     350     456 .. 0.56

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.7
                 HHHHTT--HHHHHHHHHHHHHH-TT- CS
  Coatomer_E 244 aaqhlgkdaevsernlsqlklshpeh 269
                 a+q+ ++ +  +e+++sql + + ++
  EFC37724.1  24 AIQDFEQVDSLTEKYISQLEDLSDKL 49 
                 56777888888999999998877665 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00032
                 HS---HH.HHHHHHHHHHHTT-HHHHHHHHHHHHHH-TT-HHHHHHHHHHHHHTT--HH CS
  Coatomer_E 196 kykstpl.llngkAvvslllgryeeAeslLkeaLdkdakdeetLiNlvvaaqhlgkdae 253
                 +y+++ l   +++A+v  +l++ye+A ++  + +++d+kd  +L N   + + +g  a+
  EFC37724.1 219 RYNPNHLhAHQHRAAVLYHLKEYEQAIESFTKVIEHDPKDFTALFNRGMCYKFVGELAK 277
                 5666654156899*********************************9999998887654 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.32
                 HTT-HHHHHHHHHHHHHH-TT-HHHHHHHHHHHHHTT--HH CS
  Coatomer_E 213 llgryeeAeslLkeaLdkdakdeetLiNlvvaaqhlgkdae 253
                  l+++e+A s  ++  + d+ d + ++ +  +  +l+k ++
  EFC37724.1 389 FLKKPEKALSDAEKVCELDETDVDGMMEVAMCLYDLDKVED 429
                 34555555555566666666666666666666666666644 PP

>> Pox_H7  Late protein H7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00089      0.66      79     120 ..     100     141 ..      71     155 .. 0.80
   2 ?    1.2   0.5      0.66   4.9e+02      42     111 ..     370     440 ..     351     450 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00089
                 HHHHHHHHHHHHHHH-HHHHHHH-HHHHHHHHHHT--XXXXX CS
      Pox_H7  79 aaiakeltaadiilediedyikeskklkrvikvyktkkrkki 120
                   i + +++  +i +d ++y k++k+ +++ik++  + ++++
  EFC37724.1 100 HPIHNYYMTRGLIFNDQKNYEKSTKNFRKFIKLCPEEGNNNM 141
                 35778889999***********************66555555 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.66
                 -TTS-EEEEEE-SS-BGGGGGT---EE--H.HHHHHTHHHHHHHHHHHHHHHH-HHHHHHH-HHHHHHHHH CS
      Pox_H7  42 dkdgevvidfeYdgflaSdylnaklkkltp.deyaahsaaiakeltaadiilediedyikeskklkrvikv 111
                  kdg++v  ++    +  ++l++  k+l+  +++++  ++    ++++ + l d+++   ++k+  rv+k 
  EFC37724.1 370 KKDGKFVDAYFNRANVYRRFLKKPEKALSDaEKVCELDETDVDGMMEVAMCLYDLDKVEDAKKQFERVLKT 440
                 34444443344446666777777777776414456666666777777777777777777776666666664 PP

>> MitMem_reg  Maintenance of mitochondrial structure and function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1       1.1   8.1e+02      24      51 ..      16      43 ..       7      58 .. 0.79
   2 ?   10.9   1.3    0.0006      0.45      24      74 ..      67     135 ..      52     309 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 1.1
  MitMem_reg 24 tglnrqyyslkilqerldlikdYlkkve 51
                ++l++++++++  ++  +l ++Y+ ++e
  EFC37724.1 16 SNLSKHQEAIQDFEQVDSLTEKYISQLE 43
                6789999999999999999999998887 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.0006
  MitMem_reg  24 tglnrqyyslkilqerldlikdYlkkveeg.................elpvnhe.ilrnlqkllnllPh 74 
                   l+++++slk l++ ++l k+Y+k v e                  + + n e  ++n +k+++l+P 
  EFC37724.1  67 RSLKNHENSLKSLDKAIKLGKEYNKLVTESnqkhpihnyymtrglifNDQKNYEkSTKNFRKFIKLCPE 135
                 6799************************66443333333333333332334445477777777777774 PP

>> BTAD  Bacterial transcriptional activator domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.077        58      56      94 ..     219     257 ..     203     279 .. 0.91
   2 ?    5.4   0.0      0.03        22      77     124 ..     392     439 ..     345     451 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.077
                 HHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
        BTAD  56 rleelrlealealaeaelrlGraeealaelealvaehPl 94 
                 r++   l+a++ +a+ + +l ++e+a++  ++ ++++P 
  EFC37724.1 219 RYNPNHLHAHQHRAAVLYHLKEYEQAIESFTKVIEHDPK 257
                 55667899***************************9996 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.03
                 -HHHHHHHHHHHHHHSTT-HHHHHHHHHHHHHTT-HHHHHHHHHHHHH CS
        BTAD  77 raeealaelealvaehPlrErlhrqlmrAlarsGrqaeALevYerlrr 124
                 + e+al+++e+ ++++ ++ + + ++  +l+ +++ ++A +++er+ +
  EFC37724.1 392 KPEKALSDAEKVCELDETDVDGMMEVAMCLYDLDKVEDAKKQFERVLK 439
                 456788888888888888888888888899999999999888888743 PP

>> FliJ  Flagellar FliJ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.2   0.00071      0.53       2      65 ..      23      87 ..      22     100 .. 0.90
   2 ?   -1.3   0.0       3.3   2.5e+03      52      77 ..     229     254 ..     219     264 .. 0.59
   3 ?   -1.8   0.0       4.5   3.4e+03      51      87 ..     359     395 ..     348     415 .. 0.49

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00071
        FliJ  2 eaareLaeaqrelqqaeekleeleqyrqeyqkqlsgea.qglsaaelrnyqafisaldeaiaqqk 65
                ea + ++++    +++ ++le l + +  +  q ++ + +g+s   l+n ++ +++ld+ai+  k
  EFC37724.1 23 EAIQDFEQVDSLTEKYISQLEDLSDKLPVLLTQVKSWYlKGVSERSLKNHENSLKSLDKAIKLGK 87
                66788899999999************************88*********************8655 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 3.3
        FliJ  52 afisaldeaiaqqkqelaqaekqvek 77 
                 + ++a+   +++++q+++  +k++e+
  EFC37724.1 229 QHRAAVLYHLKEYEQAIESFTKVIEH 254
                 44444444455555555555555554 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 4.5
        FliJ  51 qafisaldeaiaqqkqelaqaekqvekareewqearq 87 
                 q+ i+   +ai++  + ++   ++ + +r+ +++ ++
  EFC37724.1 359 QEAIDDFTSAIKKDGKFVDAYFNRANVYRRFLKKPEK 395
                 4444444444444444444444444444444433333 PP

>> SMBP  Small metal-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0     0.024        18      71      93 ..      68      90 ..      13      99 .. 0.86
   2 ?    2.7   0.0       0.2   1.5e+02      72     110 ..     138     176 ..     118     177 .. 0.79
   3 ?   -2.4   0.4       7.4   5.5e+03      74      84 ..     240     250 ..     223     257 .. 0.48
   4 ?   -0.9   0.0       2.5   1.9e+03      20      87 ..     351     370 ..     340     378 .. 0.61

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.024
                ---HHHHHHHHHHHHHHHHHCT- CS
        SMBP 71 ekehldegikhLeeAIkhgkagh 93
                + +  ++++k+L++AIk gk+ +
  EFC37724.1 68 SLKNHENSLKSLDKAIKLGKEYN 90
                45566899***********9865 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.2
                 --HHHHHHHHHHHHHHHHHCT-HHHHHHHHHHHHHHHHH CS
        SMBP  72 kehldegikhLeeAIkhgkaghadvAtkaaeeAlkhlka 110
                 ++ ++  i   + +I   k +  d+A +a +eA++h+ +
  EFC37724.1 138 NNNMELFIANHNLGIGLEKLDKEDEAFEAYSEAISHFGK 176
                 55556666666677888899999*************965 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 7.4
                 HHHHHHHHHHH CS
        SMBP  74 hldegikhLee 84 
                   +++i++  +
  EFC37724.1 240 EYEQAIESFTK 250
                 23344444444 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 2.5
                 XXXX--HHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHH...-------HHHHHHHHHHHHHH CS
        SMBP  20 avaaeehlaeAiehaeaAvahgkaghakalveHaeealkhakaaaekakeeekehldegikhLeeAIk 87 
                 +++ +e+ +eAi++   A+                                                k
  EFC37724.1 351 QLVKDEKYQEAIDDFTSAI------------------------------------------------K 370
                 4555556666665555554................................................3 PP

>> DUF5344  Family of unknown function (DUF5344)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1       3.4   2.5e+03      22      81 ..      25      32 ..      14      66 .. 0.57
   2 ?    6.2   0.2      0.02        15      31      57 ..      68      94 ..      41      97 .. 0.88
   3 ?    1.5   0.0      0.59   4.4e+02      50      65 ..     239     254 ..     228     262 .. 0.61
   4 ?   -0.5   0.0       2.6     2e+03      50      67 ..     356     373 ..     354     379 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 3.4
     DUF5344 22 aeelktsipetisgknsldvvekineleeeleellkaYktlllknvedtesaVdslkeaD 81
                ++                                                     +++ D
  EFC37724.1 25 IQ----------------------------------------------------DFEQVD 32
                22....................................................222222 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.02
     DUF5344 31 etisgknsldvvekineleeeleellk 57
                +  +++nsl+ ++k+ +l +e+++l++
  EFC37724.1 68 SLKNHENSLKSLDKAIKLGKEYNKLVT 94
                557899******************987 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.59
     DUF5344  50 eeleellkaYktlllk 65 
                 +e+e++++++ +++++
  EFC37724.1 239 KEYEQAIESFTKVIEH 254
                 4555555555555554 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 2.6
     DUF5344  50 eeleellkaYktlllknv 67 
                 e+++e+++++ ++++k+ 
  EFC37724.1 356 EKYQEAIDDFTSAIKKDG 373
                 689999999999999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       996  (0.0555525); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              24  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.57
# Mc/sec: 2428.14
//
Query:       EFC37725.1  [L=729]
Description: exonuclease family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.4e-12   47.2   1.6    1.4e-11   45.2   1.1    2.4  2  RNase_T          Exonuclease
    0.00077   19.2   0.6     0.0049   16.6   0.6    2.4  1  DNA_pol_A_exo1   3'-5' exonuclease
      0.009   16.3   2.4      0.009   16.3   2.4    2.7  2  EloA-BP1         ElonginA binding-protein 1
  ------ inclusion threshold ------
      0.018   14.6   0.1        2.9    7.4   0.1    2.5  2  Phosphodiest     Type I phosphodiesterase / nucleotide pyroph
      0.021   14.8   5.0      0.099   12.6   1.4    3.5  4  FAS_N            N-terminal domain in fatty acid synthase sub
      0.029   14.3   0.3       0.16   11.9   0.1    2.5  2  DUF5051          3' exoribonuclease, RNase T-like
      0.091   12.8   3.4       0.69   10.0   0.1    3.5  3  Spectrin_like    Spectrin like domain
       0.14   12.3   0.0         29    4.9   0.0    2.7  2  Tape_meas_lam_C  Lambda phage tail tape-measure protein (Tape
        4.8    7.7   9.1        7.9    7.0   0.0    4.4  6  STAT_int         STAT protein, protein interaction domain


Domain annotation for each model (and alignments):
>> RNase_T  Exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.2   1.1   7.2e-15   1.4e-11       2     164 ..     390     541 ..     389     542 .. 0.85
   2 ?   -1.7   0.0       1.9   3.8e+03      33      67 ..     567     601 ..     557     633 .. 0.72

  Alignments for each domain:
  == domain 1  score: 45.2 bits;  conditional E-value: 7.2e-15
                 EEEEEESSSTTCTTS-EEEEEEEEEETTCCEEEEEEEEEEEHSSHCSSSHHHHHHHHHCHHHHHTCEBHHH.HHHHHHHHHHHHTCCCETTTCEEEESS CS
     RNase_T   2 viDlEttgldakekdeiieiaaisidggeneigetfhfyvkptelakltdecteftgitqemldeapsfke.vleefkellrklallvahnaafdvgfl 99 
                 ++D+E+  +++   d   e+ +++++ ++  +   ++++vkp+e   + d+ t+f+git+eml++ ++  e v +e++e++ ++++lv+h  + d+ +l
  EFC37725.1 390 ALDCEMCLTKK--GD---ELTRVTFVDEQ--GTVVYDKLVKPHEQ--IIDYRTMFSGITKEMLENVETRLEdVHKEVQEFISEDTILVGHSLENDLICL 479
                 68999987776..56...56688888888..67789*********..***************9988777666*************************** PP

                 HHHHHHHHHHHHHHHHHCSEHCECHHHHHHHHHCHHHHHHHHHTTCHSSSSTSSHHHHHHHHHHH CS
     RNase_T 100 raadkrilkkevpkrnqfldtlildkatlkelartsldklaeklgleedgraHrAldDaeatakl 164
                 + a kr++   v  +n+ +   ++ k++lk l r+ l    ++  ++++g  H++ +Da+a++ l
  EFC37725.1 480 KIAHKRVIDTAVIFINASTLGTKY-KQSLKHLTRKYLSREIQVNSIDKIG--HDSSEDATAALDL 541
                 *******99988877766666666.8888888888888888888888888..********99876 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.9
                 EEEEEEEEEEHSSHCSSSHHHHHHHHHCHHHHHTC CS
     RNase_T  33 igetfhfyvkptelakltdecteftgitqemldea 67 
                  ++ f+f+ + ++ + + d+  +++gi    l +a
  EFC37725.1 567 QENVFEFLSNGEKRSVMVDRPYNLNGIVSGSLSDA 601
                 56779999999999999999999999999888776 PP

>> DNA_pol_A_exo1  3'-5' exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.6   2.5e-06    0.0049      64     136 ..     435     521 ..     376     537 .. 0.65

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 2.5e-06
                     -.................HGHHHHHHHT-TTSEEEESSHHHHHHHHHHHHTS--SSEEEHHHHHHHTTHSTTSSHHHHHHHHHSB---GH CS
  DNA_pol_A_exo1  64 v.................alealkrlledenitkvghnakfDlevlardfgielenlfdtmlaayvldyershsLdsLaekylgdleldk 136
                     +                 + + ++++++++  + vgh++++Dl +l+  ++  +   +   + a  l+++ + sL++L++kyl+  e+++
      EFC37725.1 435 FsgitkemlenvetrledVHKEVQEFISED-TILVGHSLENDLICLKIAHKRVIDTAV-IFINASTLGTKYKQSLKHLTRKYLS-REIQV 521
                     055555555555555555677888888866.599**********99986554444443.33677777777778***********.54443 PP

>> EloA-BP1  ElonginA binding-protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   3.8      0.34   6.8e+02      75     123 ..      24      71 ..       3     121 .. 0.66
   2 !   16.3   2.4   4.5e-06     0.009      41     151 ..     255     362 ..     239     377 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.34
    EloA-BP1  75 sssssavekssaksskkkvvsheavlggklaaktsfsiekkskskkeee 123
                  ++++++++++++++k+k +s +  +++++ ++ ++  e k+++ + e+
  EFC37725.1  24 TQNNNNSKENQQENKKRKNISDNSSKEEEEHTQLEIVQESKKRK-TNEK 71 
                 22233333333445555666666666666544443333333333.4444 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 4.5e-06
    EloA-BP1  41 rAleeEkavydrsssknvylnvavntlkkLrkeksssssavekssaksskkkvvsheavlggklaaktsfsiekkskskkeeelkgatlYekLkeylLt 139
                 +  ++ ++ y+ ss+k      +  tl+ L +  s+ +++ +   ++++ + + + e+ l++  +++ + +   ++++++++  +g+   + L++ lL+
  EFC37725.1 255 KTTKKTSSSYQTSSNKPFSFATVSGTLNVLENS-SKKNTKIRI--EEETIEITEKLEVTLRDDIVQEDKEEQVDNNENENDQPKNGSSKETTLNDLLLS 350
                 555666778888888888888888899999888.333333322..233344555678888888877666555555555467778899999********* PP

    EloA-BP1 140 eeqLkengyPrp 151
                 +e+L+en+yP  
  EFC37725.1 351 QEELSENNYPIF 362
                 **********74 PP

>> Phosphodiest  Type I phosphodiesterase / nucleotide pyrophosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0      0.01        20       1      32 [.     167     198 ..     167     209 .. 0.86
   2 ?    7.4   0.1    0.0015       2.9     169     233 ..     614     691 ..     483     706 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.01
                   EEEEEETT-BTTHHHHHGSTSHHHHHHHHHSE CS
  Phosphodiest   1 vlvislDGlradlldrlaellpnlaaLakegv 32 
                   v+++ lD+++ + ++++++ +pnla+ +++ +
    EFC37725.1 167 VVIVHLDSMSKEVFEKYQKSMPNLAKSMERYI 198
                   79999***********999******9888655 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0015
                   CT.....SSESEEEEEECCCHHHHHHH............-T.TSHHHHHHHHHHHHHHHHHHHHHHHTTGTTTEEEEEEES-- CS
  Phosphodiest 169 el.....ekpdlllvyleetDtvgHkf............Gp.dspevedalrrvDkaigdLlealderglsaetniilvSDHG 233
                   ++      ++dl+++++++++t   k             G  +++++++ l+++D++ ++L++++  +       +i++  HG
    EFC37725.1 614 SKkfvanSEYDLVFTHFSDLGTYYEKNdfdpiqdkdhpeGKkHDENIRAILSNLDNHFKELFQSASNN-----SLFIVTTGHG 691
                   3334555788888888888887766553344444444444436888********************99.....7799999998 PP

>> FAS_N  N-terminal domain in fatty acid synthase subunit beta
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.4   6.7e+03      58      75 ..       8      25 ..       7      50 .. 0.63
   2 ?   12.6   1.4     5e-05     0.099      36     115 ..      58     139 ..      34     149 .. 0.76
   3 ?   -2.6   0.0       2.6   5.2e+03      86      99 ..     507     519 ..     494     548 .. 0.65
   4 ?    1.2   0.0      0.17   3.4e+02      13      40 ..     680     707 ..     654     723 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.4
       FAS_N 58 akFLgyvaksiestesst 75
                + FL++v+k   s+++++
  EFC37725.1  8 SNFLELVKKGSTSSSETQ 25
                678888877655442222 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 5e-05
       FAS_N  36 tlvapseeleqeeeplseieLlakFLgyvaksiestesstsqfedvlklvleefessyLkkndihalvsn.Lpse..ttllak 115
                 + v++s++  + +e++++   l  F + v++ +++t+   s ++++l+  l+++++++L  nd +al    L  +  tt+++k
  EFC37725.1  58 EIVQESKKR-KTNEKVQSTTPLTPFQKKVSRIEKQTKVFGSDTKAILNFHLKDLKKKFLTLNDLQALMLWsLMGHscTTAKKK 139
                 445555444.445666666666789999**988899899999************************98754554444444443 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 2.6
       FAS_N  86 leefessyLkkndi 99 
                 l++++++yL+  +i
  EFC37725.1 507 LKHLTRKYLSR-EI 519
                 66777777733.22 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.17
       FAS_N  13 evsilvpaslylaaeqLrdeFtatlvap 40 
                 + s+ + +  ++++ +L++eF+++ +++
  EFC37725.1 680 NNSLFIVTTGHGNISRLEREFKKEDKQK 707
                 567788889999*********9954443 PP

>> DUF5051  3' exoribonuclease, RNase T-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   8.1e-05      0.16       3     164 ..     389     544 ..     387     546 .. 0.71
   2 ?   -2.5   0.0       2.3   4.5e+03      26      44 ..     630     648 ..     613     670 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 8.1e-05
     DUF5051   3 lmiDiEtlgneetaelvsIGaVffpetG..eFyaeidlesdeeagidaetieWWlkqskearaellkdtqeakslkdalqaleeFlekslkvwangasf 99 
                 l++D E+  ++++ el+ +  V  +e+G   + + ++++ +    id  t+       + + +e+l++      l+d+ ++++eF+ +++ +++++ + 
  EFC37725.1 389 LALDCEMCLTKKGDELTRVTFV--DEQGtvVYDKLVKPHEQI---IDYRTM------FSGITKEMLENV--ETRLEDVHKEVQEFISEDTILVGHSLEN 474
                 5678888878888888888888..888888888888886664...455555......355666777555..6889***********9999********* PP

     DUF5051 100 DlviLraafel....lipwkywndrdvrtlvala.pelekgeekkreipfe...gvkHnALaDAkhqakavsa 164
                 Dl +L+ a ++    +    + n   + t  + + ++ +  +  +rei+ +   +  H++ +DA +   +v++
  EFC37725.1 475 DLICLKIAHKRvidtA--VIFINASTLGTKYKQSlKH-LTRKYLSREIQVNsidKIGHDSSEDATAALDLVKV 544
                 ********99988541..5666666666655544333.22223455555555557889999999887777665 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2.3
     DUF5051  26 fpetGeFyaeidlesdeea 44 
                 f++ G++y+++d+++ +++
  EFC37725.1 630 FSDLGTYYEKNDFDPIQDK 648
                 3666788888888776544 PP

>> Spectrin_like  Spectrin like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0         4   8.1e+03      12      39 ..     166     193 ..     160     198 .. 0.65
   2 ?    1.1   0.1      0.21   4.1e+02      21      49 ..     431     459 ..     426     470 .. 0.84
   3 ?   10.0   0.1   0.00035      0.69      26      55 ..     657     686 ..     653     711 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4
  Spectrin_like  12 kirsltlamlktmkpeeyrqvlknLelh 39 
                    k+  + l+++++   e y++ + nL   
     EFC37725.1 166 KVVIVHLDSMSKEVFEKYQKSMPNLAKS 193
                    4445556666666677888888888765 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.21
  Spectrin_like  21 lktmkpeeyrqvlknLelhyqdFlrdSqe 49 
                     +tm ++ ++++l+n e++++d  ++ qe
     EFC37725.1 431 YRTMFSGITKEMLENVETRLEDVHKEVQE 459
                    5788888999***********98887776 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00035
  Spectrin_like  26 peeyrqvlknLelhyqdFlrdSqeSelFte 55 
                     e+ r +l+nL+ h+++  ++  + +lF +
     EFC37725.1 657 DENIRAILSNLDNHFKELFQSASNNSLFIV 686
                    57889************7777777777744 PP

>> Tape_meas_lam_C  Lambda phage tail tape-measure protein (Tape_meas_lam_C)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.023        45       8      27 ..     177     196 ..     175     199 .. 0.89
   2 ?    4.9   0.0     0.014        29      17      55 ..     659     697 ..     654     715 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.023
  Tape_meas_lam_C   8 krglaeYaesasnvagqvae 27 
                      k+ +++Y+ s++n+a+++++
       EFC37725.1 177 KEVFEKYQKSMPNLAKSMER 196
                      5789*************986 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.014
  Tape_meas_lam_C  17 sasnvagqvaeaatsafdsmedalaefvttGklsfsdla 55 
                      +++ + ++ ++ ++  f+s++++    vttG  ++s l 
       EFC37725.1 659 NIRAILSNLDNHFKELFQSASNNSLFIVTTGHGNISRLE 697
                      56667889999***********************99875 PP

>> STAT_int  STAT protein, protein interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   1.4       1.8   3.5e+03      53      95 ..      32      74 ..      18      94 .. 0.50
   2 ?    1.0   0.4      0.27   5.4e+02      48     106 ..      69     127 ..      52     138 .. 0.77
   3 ?   -4.0   0.0         9   1.8e+04      87     108 ..     173     194 ..     169     199 .. 0.62
   4 ?   -2.8   0.0       4.2   8.3e+03      61      78 ..     440     457 ..     428     473 .. 0.53
   5 ?    7.0   0.0     0.004       7.9      21      73 ..     503     556 ..     496     600 .. 0.74
   6 ?    1.5   0.1       0.2     4e+02      38     111 ..     638     719 ..     632     719 .. 0.54

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.8
    STAT_int 53 eslatalleelleeleekasrlseeenflqklklreiaknlqk 95
                e++ ++   + ++   +k ++  ++ +++q+ k r++++++q+
  EFC37725.1 32 ENQQENKKRKNISDNSSKEEEEHTQLEIVQESKKRKTNEKVQS 74
                2222222223333333333333333345666666666655555 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.27
    STAT_int  48 dnpedeslatalleelleeleekasrlseeenflqklklreiaknlqkkyqenPleLar 106
                 +++ ++++  + +++ ++++e++++ + ++ + +++ +l++++k++ +  + ++l L +
  EFC37725.1  69 NEKVQSTTPLTPFQKKVSRIEKQTKVFGSDTKAILNFHLKDLKKKFLTLNDLQALMLWS 127
                 3444666666778999999999*999999999999******999998877777776665 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 9
    STAT_int  87 reiaknlqkkyqenPleLarii 108
                   ++k++ +kyq++  +La+ +
  EFC37725.1 173 DSMSKEVFEKYQKSMPNLAKSM 194
                 5566666666777766666655 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 4.2
    STAT_int  61 eelleeleekasrlseee 78 
                 +e+le++e++++++ +e 
  EFC37725.1 440 KEMLENVETRLEDVHKEV 457
                 444444444444444332 PP

  == domain 5  score: 7.0 bits;  conditional E-value: 0.004
    STAT_int  21 YeekfPievRhyLaewiEsqdweeiapdnpedeslatalleellee.leekasr 73 
                 Y++++ +  R+yL+  i  ++ ++i +d++ed + a  l++ +l+e +e  ++r
  EFC37725.1 503 YKQSLKHLTRKYLSREIQVNSIDKIGHDSSEDATAALDLVKVVLKEgIEYVHKR 556
                 899999999*******************************99998734444444 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.2
    STAT_int  38 Esqdweeia.pdnpe...deslatalleelleeleekasrlseeenflq...klklreiaknl.qkkyqenPleLariikei 111
                 E++d + i+ +d+pe   ++++++a+l++l ++ +e  ++ s+++ f+    + ++ ++ +++ ++  q+++ e++++i+++
  EFC37725.1 638 EKNDFDPIQdKDHPEgkkHDENIRAILSNLDNHFKELFQSASNNSLFIVttgHGNISRLEREFkKEDKQKRAKEIINMIENC 719
                 5666665552222222225555555555555555555555555554432111457888888883345677788888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (729 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2796  (0.155948); expected 358.6 (0.02)
Passed bias filter:                      619  (0.0345251); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.97u 0.30s 00:00:01.27 Elapsed: 00:00:00.51
# Mc/sec: 4260.60
//
Query:       EFC37726.1  [L=278]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
        6.3    7.1  12.2         11    6.3   5.1    2.8  3  Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
        8.9    5.7  11.2        6.8    6.1   0.1    2.2  2  Sec62         Translocation protein Sec62
        9.9    6.7   6.8        3.9    8.0   2.5    2.2  2  DUF1493       Protein of unknown function (DUF1493)


Domain annotation for each model (and alignments):
>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.2      0.98   5.9e+03      54      54 ..      20      20 ..       2      56 .. 0.53
   2 ?    4.5   0.0    0.0066        39       2      25 ..     141     164 ..     141     168 .. 0.91
   3 ?    6.3   5.1    0.0018        11      30     101 ..     196     270 ..     180     273 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.98
                  H CS
  Seryl_tRNA_N 54 e 54
                  +
    EFC37726.1 20 Q 20
                  1 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0066
                   --HHHHHH-HHHHHHHHCCCTCCC CS
  Seryl_tRNA_N   2 LDiklirenpeavkeklkkRgedk 25 
                   LD + +r+++e+++ek++++ +d+
    EFC37726.1 141 LDTDRVRTDFEKLAEKVNSKSGDN 164
                   899***************999876 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0018
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCTT...S-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  30 elleldekrrelqveleelqaerNelskeIgkakkkk...edaeeliaevkelkeelkaleaelkeleaelekll 101
                   + +elde   +  v+ eel + + ++  e+ k  +k    ++ +e  ++ +el   l++++++lke ++el++l+
    EFC37726.1 196 KKYELDEDEVADLVDEEELYSLKRSVRLEFTKHLRKFlnqDNENESTNDLSELTSSLETIDDDLKECKDELDDLM 270
                   44566666666666777776666666666666665545545778889999999999***************9998 PP

>> Sec62  Translocation protein Sec62
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   6.7     0.023   1.4e+02      13      78 ..       5      66 ..       1      87 [. 0.43
   2 ?    6.1   0.1    0.0011       6.8      70      98 ..     175     215 ..     134     218 .. 0.66

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.023
       Sec62 13 ralksekekkkskkkkeklkevkkkekaekvfkelkksqlalrveklkekekkkkkeekkkkkkkk 78
                r+ ks++++k+++k++++++ ++++++ ++++k++ +++l+++++++++k+++++    +++ +kk
  EFC37726.1  5 RQVKSTDDEKSNRKTQSSSTLTDHDKNIHTTSKASSSDSLVTSTTSTSKKKSTSS----RGEGRKK 66
                3333444444444443333333333343444444444444444333333332222....2333333 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0011
       Sec62  70 e............kkkkkkkkkkvkleieeeqefvddnevY 98 
                              k+k+++++kk +l+  e +++vd++e Y
  EFC37726.1 175 VnahganptkesiKQKREHNRKKYELDEDEVADLVDEEELY 215
                 0333333333344789999********************99 PP

>> DUF1493  Protein of unknown function (DUF1493)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.25   1.5e+03      35      50 ..     195     210 ..     180     217 .. 0.75
   2 ?    8.0   2.5   0.00065       3.9      26      53 ..     246     274 ..     219     276 .. 0.69

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.25
     DUF1493  35 dedlkldeddaedlle 50 
                 +++++lded++ dl++
  EFC37726.1 195 RKKYELDEDEVADLVD 210
                 5788899999988876 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00065
     DUF1493  26 veltld.tdldedlkldeddaedllekff 53 
                  elt + + +d+dlk  +d+++dl+++ff
  EFC37726.1 246 SELTSSlETIDDDLKECKDELDDLMDTFF 274
                 4455442469******************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (278 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1948  (0.108651); expected 358.6 (0.02)
Passed bias filter:                      679  (0.0378716); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 1587.78
//
Query:       EFC37727.1  [L=457]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-44  152.2  19.7    2.2e-42  145.5  19.7    2.1  1  Zip       ZIP Zinc transporter


Domain annotation for each model (and alignments):
>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  145.5  19.7   1.2e-46   2.2e-42       2     333 .]      43     454 ..      42     454 .. 0.73

  Alignments for each domain:
  == domain 1  score: 145.5 bits;  conditional E-value: 1.2e-46
         Zip   2 llkilaiiaililsllgllgpllvpkiskl.......lsklllslllafavGvllgtaflhLlPealealeesqleeehth......plagllvllGfl 87 
                 ++k++ ++ +li s+l  l+p+l+++ +         + + ++     fa+Gvll+ ++lh+++e+ e ++e  ++           p   l+++l+fl
  EFC37727.1  43 GAKLGTLFGLLIGSFLISLVPILFSRVKYFkkrinsgYISIAIDQCNGFAGGVLLSVGILHMMAEGGELISEGLESLG--DsrssayPIGPLTMCLAFL 139
                 789999******************9887668899999***************************99988887654332..2345788************ PP

         Zip  88 llllveklltmivek.......ksshkektpkkasssssesaakksvsndkveeseek......................................... 138
                 +l+ +e++l  + +k       ++ h++  ++ +s+s+s+++ ++ ++ +++++ + +                                         
  EFC37727.1 140 VLYGLEFVLLAFLSKwfkagehDHGHSHGHSHGHSHSHSNCDHSHGHDHKEHQTLTSNgakspppsistigcvdeiemvkphkeetpsspvdsddievk 238
                 ************9999****7633333333444444444333333333333333333345566777778777777766666666666666666666666 PP

         Zip 139 ..................edhvaeadtdadskeelrngkqeksesekeqas.............eeedkeklaslkvraiilllglilHsfidGLAlGv 206
                                   + +++ ++ ++   +e+ +g++          +              e ++++   l + ai+l l+l+ Hs+++GL +G+
  EFC37727.1 239 neeegdlenpetpqiektTTNEPTVCDQHHVHHEHGHGHG----------DhtgcahheatqmlFETNHKSGVPLVLTAIVLWLALSTHSIFIGLGFGA 327
                 6655555544333333332222222222222222222232..........1334444444455556666666777777********************* PP

         Zip 207 ssssstgislfiAvllHelpeelglgaiLlkaglsrkkavllnllfaltaplGiliGilvrs......isessgaeivsgillalsaGtflYvalvell 299
                   +   ++s+f+A++ H+++e+++lgai+ k   +   a+ l +l+a++ p+Gi+iG+ +++      + e+   ++++g ll+++aG flYval+e+ 
  EFC37727.1 328 ETDLGNMWSIFAAIVAHQFIEAFSLGAIVEKGCKNIFVALALLFLYAASVPVGIAIGLIIIHsvqneqALENNSWKVAQGTLLSIAAGAFLYVALMEIA 426
                 ***************************87666666666669*********************9875443333344579********************9 PP

         Zip 300 phEllnekgssslkqsllqllglllGfalmllla 333
                   +  +     +  ++l+ ++++ lGfa m+++a
  EFC37727.1 427 I-HQPK-----NKFLKLSRFILMALGFASMAIIA 454
                 8.3333.....4479*****************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (457 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       777  (0.0433376); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2627.80
//
Query:       EFC37728.1  [L=481]
Description: LRR_RI domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.3e-18   63.3  30.9    2.8e-05   23.8   0.4   10.7 13  LRR_6       Leucine Rich repeat
    1.4e-16   60.0  24.7      5e-06   26.2   1.5    7.3  8  LRR_8       Leucine rich repeat
    1.2e-13   51.0  43.6    1.3e-06   28.6   1.7    9.3 11  LRR_4       Leucine Rich repeats (2 copies)
    1.3e-08   34.2  35.8       0.18   12.5   0.6   10.3 11  LRR_1       Leucine Rich Repeat
      3e-08   33.4   0.2    2.7e-07   30.4   0.0    2.4  2  F-box-like  F-box-like
    1.5e-05   24.7   0.0    8.2e-05   22.4   0.0    2.3  2  F-box       F-box domain
     0.0085   16.0   1.8      0.027   14.4   1.1    2.3  2  DUF4957     Domain of unknown function (DUF4957)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       3.7   9.4e+03       3      14 ..     110     121 ..     110     123 .. 0.79
   2 ?   -3.3   0.1       5.4   1.4e+04       3      17 ..     142     156 ..     141     156 .. 0.75
   3 ?    1.7   0.0      0.14   3.5e+02       3      19 ..     168     184 ..     166     189 .. 0.82
   4 !   23.8   0.4   1.1e-08   2.8e-05       2      24 .]     218     240 ..     217     240 .. 0.92
   5 !    9.5   0.1   0.00041       1.1       3      15 ..     244     256 ..     242     258 .. 0.90
   6 ?    3.7   0.0     0.032        81       1      15 [.     267     281 ..     267     289 .. 0.92
   7 !   14.4   0.0   1.2e-05      0.03       4      23 ..     294     313 ..     293     314 .. 0.91
   8 ?   -3.4   0.0       5.9   1.5e+04       6      17 ..     321     332 ..     320     338 .. 0.74
   9 !    6.1   0.0    0.0054        14       3      21 ..     344     362 ..     343     364 .. 0.89
  10 ?    5.1   0.2     0.011        27       3      16 ..     370     383 ..     370     391 .. 0.86
  11 !   11.8   0.1   7.8e-05       0.2       3      20 ..     396     413 ..     394     417 .. 0.88
  12 ?    1.1   0.5      0.21   5.5e+02       4      13 ..     423     432 ..     422     432 .. 0.92
  13 ?   -2.8   0.0       3.7   9.4e+03       3      15 ..     448     460 ..     448     461 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3.7
       LRR_6   3 thLteLdLsgNd 14 
                 t+++eL+L +++
  EFC37728.1 110 TNIQELSLHDCG 121
                 578999998887 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 5.4
       LRR_6   3 thLteLdLsgNdIgD 17 
                 +++++L++ g  I+D
  EFC37728.1 142 NNIRKLEIHGLRITD 156
                 567888888888887 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.14
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                 + L+eL L ++ I+D G
  EFC37728.1 168 PFLQELKLDHCMISDYG 184
                 679********999966 PP

  == domain 4  score: 23.8 bits;  conditional E-value: 1.1e-08
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  t+L+ LdLs+N+I+ eGa+ L+
  EFC37728.1 218 LTNLKILDLSHNCISSEGAKYLS 240
                 689****************9885 PP

  == domain 5  score: 9.5 bits;  conditional E-value: 0.00041
       LRR_6   3 thLteLdLsgNdI 15 
                 +++++LdLs+N+I
  EFC37728.1 244 QNMEYLDLSFNNI 256
                 789*********9 PP

  == domain 6  score: 3.7 bits;  conditional E-value: 0.032
       LRR_6   1 snthLteLdLsgNdI 15 
                 +nt++++L + gN+I
  EFC37728.1 267 KNTSMRKLIIVGNNI 281
                 69************9 PP

  == domain 7  score: 14.4 bits;  conditional E-value: 1.2e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 ++t+Ld++gN +g eGa+ +
  EFC37728.1 294 SITHLDMTGNPLGYEGASFI 313
                 68***************977 PP

  == domain 8  score: -3.4 bits;  conditional E-value: 5.9
       LRR_6   6 teLdLsgNdIgD 17 
                 ++L +++ +I+ 
  EFC37728.1 321 RTLKIADAKINS 332
                 789999988876 PP

  == domain 9  score: 6.1 bits;  conditional E-value: 0.0054
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 ++L eL+L gN +gDeG+ 
  EFC37728.1 344 NNLSELSLEGNFFGDEGCV 362
                 6899*************75 PP

  == domain 10  score: 5.1 bits;  conditional E-value: 0.011
       LRR_6   3 thLteLdLsgNdIg 16 
                 ++L++L L+ N+I+
  EFC37728.1 370 SNLKKLKLNRNCIT 383
                 68***********8 PP

  == domain 11  score: 11.8 bits;  conditional E-value: 7.8e-05
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                  +L+eL+Ls+N I   G+
  EFC37728.1 396 KSLQELNLSFNRIKTRGI 413
                 58***********99986 PP

  == domain 12  score: 1.1 bits;  conditional E-value: 0.21
       LRR_6   4 hLteLdLsgN 13 
                 +L+ L+L++N
  EFC37728.1 423 NLEVLNLTSN 432
                 79*******9 PP

  == domain 13  score: -2.8 bits;  conditional E-value: 3.7
       LRR_6   3 thLteLdLsgNdI 15 
                 ++L+ L L+gN +
  EFC37728.1 448 SKLKVLLLMGNRF 460
                 5799999999976 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.2   3.1e+03      45      59 ..     106     120 ..     100     122 .. 0.70
   2 ?    1.3   0.0      0.11   2.9e+02      22      60 ..     139     179 ..     135     180 .. 0.78
   3 !   24.4   4.0   6.9e-09   1.8e-05       2      61 .]     196     256 ..     195     256 .. 0.89
   4 !   13.0   0.3   2.5e-05     0.065      24      61 .]     243     281 ..     235     281 .. 0.93
   5 ?    4.6   0.0     0.011        27      25      61 .]     269     305 ..     264     305 .. 0.74
   6 !   26.2   1.5   1.9e-09     5e-06       2      61 .]     345     408 ..     343     408 .. 0.91
   7 !    8.9   0.5   0.00047       1.2      25      59 ..     422     458 ..     412     460 .. 0.61
   8 !   10.2   0.8   0.00019      0.49       2      41 ..     423     464 ..     422     473 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.2
                 GTT--S-.EEE--SS CS
       LRR_8  45 fsgLpsLrsLdLsgN 59 
                 +++++++++L L ++
  EFC37728.1 106 CRHFTNIQELSLHDC 120
                 567778888888765 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.11
                 TT-TT--EEE--SS---GGGGGGGTT--S..-.EEE--SS- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLps..LrsLdLsgNr 60 
                  +l+n + L++   ++t +  + fs  p+  L++L L+++ 
  EFC37728.1 139 GNLNNIRKLEIHGLRITDFACREFSRTPKpfLQELKLDHCM 179
                 57888888888888888888888888877779999999886 PP

  == domain 3  score: 24.4 bits;  conditional E-value: 6.9e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 n++sL+++ + ++  + +  ++l+nLk+LdLs+N++++   +   s+L + ++LdLs N++
  EFC37728.1 196 NVYSLSVTASAIELDSCKELSNLTNLKILDLSHNCISSeGAKYLSSCLQNMEYLDLSFNNI 256
                 778888888888888888899*****************76677889*************97 PP

  == domain 4  score: 13.0 bits;  conditional E-value: 2.5e-05
                 -TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 l+n+++LdLs N+++  ++  + +  +s r+L + gN++
  EFC37728.1 243 LQNMEYLDLSFNNIEEgFESLCSQKNTSMRKLIIVGNNI 281
                 89*************99********************97 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.011
                 TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  25 snLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++++ L +  N++     + + +++s+++Ld++gN+L
  EFC37728.1 269 TSMRKLIIVGNNIPGSACKNIGNFESITHLDMTGNPL 305
                 5566666777777777777788888999999999986 PP

  == domain 6  score: 26.2 bits;  conditional E-value: 1.9e-09
                 T-SEEE-TTS--SEE-TTSSTT..-TT--EEE--SS---G..GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg..lsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsgNrL 61 
                 nL++L+L  N + + +  +F++  +snLk L+L++N++t    ++ a++ L+sL++L+Ls Nr+
  EFC37728.1 345 NLSELSLEGNFFGDEGCVVFQSpmFSNLKKLKLNRNCITCfgCENLACDTLKSLQELNLSFNRI 408
                 8999*****************9999**************94446778899************97 PP

  == domain 7  score: 8.9 bits;  conditional E-value: 0.00047
                 TT--EEE--SS---GGGGGGGTT..--S-.EEE--SS CS
       LRR_8  25 snLkvLdLsnNllttlspgafsg..LpsLrsLdLsgN 59 
                 +nL+vL+L++N l t+    f    +++L+ L L gN
  EFC37728.1 422 ENLEVLNLTSNFLPTIAIPLFKKpvFSKLKVLLLMGN 458
                 5788888888888877655555433345555555555 PP

  == domain 8  score: 10.2 bits;  conditional E-value: 0.00019
                 T-SEEE-TTS--SEE-TTSSTT..-TT--EEE--SS---GGG CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg..lsnLkvLdLsnNllttls 41 
                 nL++L+L++N l  +    Fk+  +s+LkvL L  N+ +t s
  EFC37728.1 423 NLEVLNLTSNFLPTIAIPLFKKpvFSKLKVLLLMGNRFSTCS 464
                 899999999999999999999999999999999999998876 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.1      0.15   3.8e+02      20      36 ..     107     123 ..     101     131 .. 0.75
   2 ?    1.3   0.4       0.2   5.2e+02       1      31 [.     110     150 ..     110     159 .. 0.52
   3 !   10.7   3.7   0.00022      0.57      18      36 ..     214     231 ..     168     233 .. 0.81
   4 !   28.6   1.7   5.2e-10   1.3e-06       1      39 [.     219     256 ..     219     265 .. 0.88
   5 !   14.2   0.3   1.8e-05     0.045       1      36 [.     244     282 ..     244     288 .. 0.81
   6 ?    4.9   0.0     0.015        39       4      35 ..     272     304 ..     269     309 .. 0.65
   7 ?    2.1   0.0      0.11   2.8e+02       3      30 ..     295     325 ..     293     333 .. 0.57
   8 ?    3.4   0.2     0.042   1.1e+02      20      33 ..     340     354 ..     318     359 .. 0.69
   9 !   19.6   4.4   3.6e-07   0.00093       2      36 ..     371     408 ..     370     416 .. 0.84
  10 !   19.7   3.6   3.3e-07   0.00084       1      36 [.     396     434 ..     396     441 .. 0.78
  11 ?    2.2   0.1       0.1   2.6e+02       2      22 ..     449     473 ..     448     481 .] 0.68

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.15
                 HH-TT--EEE-.-S--- CS
       LRR_4  20 eklpnLkeLdLsgNnli 36 
                 + ++n +eL+L+++ +i
  EFC37728.1 107 RHFTNIQELSLHDCGFI 123
                 56899999999777555 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.2
                 SS--EEE--SS---E-S-HH..........H-TT--EEE-. CS
       LRR_4   1 pnLevLdLsnNqltdiplle..........klpnLkeLdLs 31 
                 +n ++L+L+++    i + +          +l n ++L ++
  EFC37728.1 110 TNIQELSLHDCGFINIFNEQenayietvmgNLNNIRKLEIH 150
                 57777777776444333322234444555446666666664 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00022
                 -HHH-TT--EEE-.-S--- CS
       LRR_4  18 lleklpnLkeLdLsgNnli 36 
                  l++l+nLk LdLs+N  i
  EFC37728.1 214 ELSNLTNLKILDLSHN-CI 231
                 3557999999999888.44 PP

  == domain 4  score: 28.6 bits;  conditional E-value: 5.2e-10
                 SS--EEE--SS---E-S-..HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitdl 39 
                 +nL++LdLs+N++++ +   l++ l n+++LdLs+Nn    +
  EFC37728.1 219 TNLKILDLSHNCISSEGAkyLSScLQNMEYLDLSFNN----I 256
                 7**************999998888*********9994....3 PP

  == domain 5  score: 14.2 bits;  conditional E-value: 1.8e-05
                 SS--EEE--SS---.E-S-HH..H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqlt.diplle..klpnLkeLdLsgNnli 36 
                 +n e+LdLs N++   +++l   k++++++L + gNn +
  EFC37728.1 244 QNMEYLDLSFNNIEeGFESLCsqKNTSMRKLIIVGNNIP 282
                 689***********7777733447999****99999654 PP

  == domain 6  score: 4.9 bits;  conditional E-value: 0.015
                 -EEE--SS---E-S-....HHH-TT--EEE-.-S-- CS
       LRR_4   4 evLdLsnNqltdipl....leklpnLkeLdLsgNnl 35 
                 ++L + +N++    +    ++++ + ++Ld++gN +
  EFC37728.1 272 RKLIIVGNNIPG--SacknIGNFESITHLDMTGN-P 304
                 556666666553..2223344799*******999.4 PP

  == domain 7  score: 2.1 bits;  conditional E-value: 0.11
                 --EEE--SS---E-S-..HHH.-TT--EEE- CS
       LRR_4   3 LevLdLsnNqltdipl..lek.lpnLkeLdL 30 
                  ++Ld  +N l   +   ++k l+  ++L +
  EFC37728.1 295 ITHLDMTGNPLGYEGAsfISKgLKEIRTLKI 325
                 5677777777773333443333777777766 PP

  == domain 8  score: 3.4 bits;  conditional E-value: 0.042
                 HH.-TT--EEE-.-S CS
       LRR_4  20 ek.lpnLkeLdLsgN 33 
                 e+ + nL eL+L gN
  EFC37728.1 340 EGiMNNLSELSLEGN 354
                 36699*******999 PP

  == domain 9  score: 19.6 bits;  conditional E-value: 3.6e-07
                 S--EEE--SS---E-S-HH....H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplle....klpnLkeLdLsgNnli 36 
                 nL++L L+ N++t ++  +     l++L+eL+Ls+N +i
  EFC37728.1 371 NLKKLKLNRNCITCFGCENlacdTLKSLQELNLSFN-RI 408
                 9*************8884455856*********888.66 PP

  == domain 10  score: 19.7 bits;  conditional E-value: 3.3e-07
                 SS--EEE--SS---E-S-..HH..H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..klpnLkeLdLsgNnli 36 
                 ++L++L+Ls N++++ +   l+  k+ nL++L+L++N ++
  EFC37728.1 396 KSLQELNLSFNRIKTRGInfLSegKFENLEVLNLTSN-FL 434
                 68***********965556544767*********888.44 PP

  == domain 11  score: 2.2 bits;  conditional E-value: 0.1
                 S--EEE--SS---E-S-...HHH.- CS
       LRR_4   2 nLevLdLsnNqltdipl...lek.l 22 
                 +L+vL L +N+ ++ ++   l+  +
  EFC37728.1 449 KLKVLLLMGNRFSTCSSsssLKDiF 473
                 8**********88777733333444 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.2      0.83   2.1e+03       1      16 [.     111     126 ..     111     129 .. 0.81
   2 ?    0.2   0.1      0.73   1.9e+03       2      13 ..     170     181 ..     169     196 .. 0.80
   3 !   12.5   0.6     7e-05      0.18       1      23 []     220     242 ..     220     243 .. 0.90
   4 !    6.2   0.2    0.0079        20       1      21 [.     245     266 ..     245     268 .. 0.77
   5 ?   -3.9   0.0         7   1.8e+04       5      12 ..     274     281 ..     272     287 .. 0.53
   6 ?    5.4   0.0     0.015        37       2      13 ..     295     306 ..     294     323 .. 0.73
   7 ?    3.9   0.0     0.045   1.1e+02       1      14 [.     345     358 ..     345     370 .. 0.79
   8 !    6.4   0.7    0.0068        18       1      16 [.     371     386 ..     371     391 .. 0.87
   9 !    6.7   0.2    0.0053        14       1      18 [.     397     414 ..     397     419 .. 0.76
  10 !    9.2   0.0    0.0008       2.1       1      20 [.     423     442 ..     423     446 .. 0.82
  11 ?    0.1   0.1      0.78     2e+03       1      20 [.     449     469 ..     449     473 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.83
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 n ++L L ++ ++++ 
  EFC37728.1 111 NIQELSLHDCGFINIF 126
                 7899******987655 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.73
       LRR_1   2 LrhLdLsnnpll 13 
                 L++L L ++ ++
  EFC37728.1 170 LQELKLDHCMIS 181
                 99******9874 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 7e-05
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ LdLs+n++++ ++ +++++
  EFC37728.1 220 NLKILDLSHNCISSEGAKYLSSC 242
                 8***********99999888876 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0079
       LRR_1   1 nLrhLdLsnnpl.lglppnsfq 21 
                 n ++LdLs n++ +g+++ + q
  EFC37728.1 245 NMEYLDLSFNNIeEGFESLCSQ 266
                 5699*******97777766665 PP

  == domain 5  score: -3.9 bits;  conditional E-value: 7
       LRR_1   5 LdLsnnpl 12 
                 L + +n++
  EFC37728.1 274 LIIVGNNI 281
                 55544544 PP

  == domain 6  score: 5.4 bits;  conditional E-value: 0.015
       LRR_1   2 LrhLdLsnnpll 13 
                  +hLd+++npl+
  EFC37728.1 295 ITHLDMTGNPLG 306
                 68********93 PP

  == domain 7  score: 3.9 bits;  conditional E-value: 0.045
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL +L L++n++++
  EFC37728.1 345 NLSELSLEGNFFGD 358
                 899********954 PP

  == domain 8  score: 6.4 bits;  conditional E-value: 0.0068
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 nL++L L++n++++++
  EFC37728.1 371 NLKKLKLNRNCITCFG 386
                 8***********9986 PP

  == domain 9  score: 6.7 bits;  conditional E-value: 0.0053
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L+Ls n++   ++n
  EFC37728.1 397 SLQELNLSFNRIKTRGIN 414
                 69*********9555555 PP

  == domain 10  score: 9.2 bits;  conditional E-value: 0.0008
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL++L+L++n+l+ + ++ f
  EFC37728.1 423 NLEVLNLTSNFLPTIAIPLF 442
                 8**********977666666 PP

  == domain 11  score: 0.1 bits;  conditional E-value: 0.78
       LRR_1   1 nLrhLdLsnnpl.lglppnsf 20 
                 +L++L L +n++ ++ +++s+
  EFC37728.1 449 KLKVLLLMGNRFsTCSSSSSL 469
                 799999988888677777666 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.4   0.0   1.1e-10   2.7e-07       5      43 ..      45      85 ..      41      89 .. 0.82
   2 ?   -0.1   0.1      0.34   8.6e+02      24      34 ..     102     112 ..      97     115 .. 0.81

  Alignments for each domain:
  == domain 1  score: 30.4 bits;  conditional E-value: 1.1e-10
  F-box-like  5 PdE.iLlqIFsyLppsdLlrlalVCrrWrrvaldt.plLWr 43
                PdE   ++IFsyL++++L+ +a VC++W ++ + t  +L++
  EFC37728.1 45 PDElFYMEIFSYLEFESLAKCAMVCKKWFNASAQTaTSLYH 85
                77733479********************9998666468887 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.34
  F-box-like  24 lalVCrrWrrv 34 
                 +a VCr++ ++
  EFC37728.1 102 VASVCRHFTNI 112
                 699***99765 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.0   3.2e-08   8.2e-05       5      35 ..      43      74 ..      39      77 .. 0.83
   2 ?   -2.8   0.0       2.5   6.4e+03      27      33 ..     103     109 ..     101     114 .. 0.81

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 3.2e-08
                HS-HH.HHHHHHHTS-HHHHHHHCTT-HHHHH CS
       F-box  5 rLPse.vlrhILerLplsdllalrrVSkgwri 35
                ++P+e   ++I+++L++ +l  ++ V+k+w +
  EFC37728.1 43 EVPDElFYMEIFSYLEFESLAKCAMVCKKWFN 74
                566666669*********************65 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.5
                 CTT-HHH CS
       F-box  27 rrVSkgw 33 
                 ++V++++
  EFC37728.1 103 ASVCRHF 109
                 789*998 PP

>> DUF4957  Domain of unknown function (DUF4957)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   1.1   1.1e-05     0.027      25     114 ..     131     213 ..     111     233 .. 0.82
   2 ?   -1.9   0.0       1.1   2.9e+03     113     129 ..     330     346 ..     317     349 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.1e-05
     DUF4957  25 hpkitlgkgnasistgasLkiknldldgsasdssfialsetpdetikdtltiqnCeikdvnkgliydnnkkyviesivinnclvkniess 114
                 ++ i  +   +++++  +L+i  l +     d +  ++s tp+ ++ ++l+++ C i+d++   + +nn+ + + s++++ + +++ +++
  EFC37728.1 131 NAYI--ETVMGNLNNIRKLEIHGLRIT----DFACREFSRTPKPFL-QELKLDHCMISDYGFSNLARNNTLSNVYSLSVTASAIELDSCK 213
                 4444..444466677677777776664....667789*********.**********************9************99998886 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.1
     DUF4957 113 ssggdiidfkkgfinnl 129
                  +++++i+  +g +nnl
  EFC37728.1 330 INSSAMIYLSEGIMNNL 346
                 34678999999999988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      514  (0.0286686); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 2699.35
//
Query:       EFC37729.1  [L=496]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.8e-47  159.5  14.2    1.9e-46  158.5  14.2    1.4  1  Gpi1           N-acetylglucosaminyl transferase component (Gp
  ------ inclusion threshold ------
      0.027   14.3   0.1        3.3    7.5   0.1    2.5  2  Peptidase_C39  Peptidase C39 family


Domain annotation for each model (and alignments):
>> Gpi1  N-acetylglucosaminyl transferase component (Gpi1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.5  14.2   2.1e-50   1.9e-46       6     187 .]     180     376 ..     176     376 .. 0.89

  Alignments for each domain:
  == domain 1  score: 158.5 bits;  conditional E-value: 2.1e-50
        Gpi1   6 lilnDvllGilllslllenaev.iaeliek..lleellvdslekllewls..gnPaGlKLNkeLasflgklflwviklwks.......llesll..sll 90 
                  +++D++lG+l+++ +++  e+ +++l ++  +l ++++ ++ +++ewl   +nP+G+KLNk+L+ +lg+++l  +++w++       +l++++  +l+
  EFC37729.1 180 NMILDLILGFLIIYHVWKLDEStLIDLKKRfiSLYKYILINMFQHFEWLIkdSNPGGIKLNKQLNIILGQMALGGLRWWQTllsfgfyYLSDFFtvDLF 278
                 689***********99998655145555554667889999999******5469****************************777766655555456777 PP

        Gpi1  91 elllkllallsllGltfalsllsDllslltlhiylfyvlsariyrlqlevlksLfqlfrGkkyNvLrnrvDsld.yeldqlllGtllFtvlvfLlPTv 187
                 ++l++ ++ ++l+G++++l+l++Dll +++++i lfy +++r+y++ ++++ sL++lfrGkk N+L++r+D+++ y+ dql+lG++lFt+++fL+PTv
  EFC37729.1 279 RVLIWSISSSCLMGASTMLALVCDLLLVVSINILLFYRIISRLYNQLIHLIFSLWRLFRGKKANPLKKRLDNCEdYSNDQLILGIILFTICIFLYPTV 376
                 8888*********************************************************************88**********************8 PP

>> Peptidase_C39  Peptidase C39 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.1   0.00037       3.3      35     114 ..     167     241 ..     152     243 .. 0.87
   2 ?    4.0   0.0    0.0044        39      27      66 ..     405     444 ..     395     462 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00037
  Peptidase_C39  35 relagtdeeGlslsgLkkaakklglkakaikadlkelkelklpaIahwdgklkHfvvvekikkkkvliadPakgkiklsk 114
                    ++l ++++ G+s++ ++ +   + +  ++ k+d ++l +lk ++I     k   +++++  +  ++li d + g ikl+k
     EFC37729.1 167 KHLENISRIGMSFNMILDLILGFLIIYHVWKLDESTLIDLKKRFISLY--K---YILINMFQHFEWLIKDSNPGGIKLNK 241
                    4678999***************************************53..3...9****************999999987 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.0044
  Peptidase_C39  27 sevsleeLrelagtdeeGlslsgLkkaakklglkakaika 66 
                    ++ ++++L +l g ++eG+++++Lk+  + l +  ++i +
     EFC37729.1 405 HNFPINQLLNLNGCRNEGIKFTTLKNGYNYLHIHSSKIPL 444
                    68899*********************99999888777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       846  (0.0471861); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 2755.85
//
Query:       EFC37730.1  [L=269]
Description: hypothetical protein NAEGRDRAFT_81847 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       223  (0.0124379); expected 358.6 (0.02)
Passed bias filter:                      192  (0.0107089); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1696.32
//
Query:       EFC37731.1  [L=570]
Description: protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-56  191.4   0.1      3e-56  190.7   0.1    1.3  1  Pkinase         Protein kinase domain
    1.1e-31  110.1   0.0    2.1e-31  109.2   0.0    1.5  1  Pkinase_Tyr     Protein tyrosine kinase
    9.1e-05   21.4   0.3    0.00025   20.0   0.3    1.8  1  Pkinase_fungal  Fungal protein kinase
    0.00073   18.6   0.6    0.00073   18.6   0.6    2.3  3  Haspin_kinase   Haspin like kinase domain
  ------ inclusion threshold ------
      0.053   12.8   0.0      0.098   11.9   0.0    1.4  1  Kinase-like     Kinase-like
       0.14   11.4   1.3       0.28   10.4   1.3    1.4  1  GTA_TIM         GTA TIM-barrel-like domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  190.7   0.1     1e-59     3e-56       2     263 ..     277     539 ..     276     540 .. 0.92

  Alignments for each domain:
  == domain 1  score: 190.7 bits;  conditional E-value: 1e-59
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHH CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllerkgslseee 99 
                 e+++klGeG++++V  ++ ++tgk +A K++k  k+ + k   +l+Ei+ l ++  ++ni+rly++   ++++ ++ley++g++l++l     +++e+ 
  EFC37731.1 277 ETIKKLGEGASSTVELVK-DNTGKLYAKKIVKLAKDIQPK--LILSEITTLYNCVeCSNILRLYNANFADNKINILLEYMDGNSLESLAG--IKIPERI 370
                 6789**********9999.7*************9888766..5******9998877******************************9995..78***** PP

                 HHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..............BCTTTSCGGGS-HHHHTTSCBSHHHHHHHH CS
     Pkinase 100 akkiakqilegleylH.skgiiHrDlKpeNiLidekgelKitDFGlakelesssk..............ltsfvgtseYlAPEvlkeneyskkvDvWsl 183
                 ++ i+ q+l+gl +lH +k+i+HrDlKp+NiLi+ +ge+Ki+D Gl   ++++++               ++  gt  Y++PE ++e+++s ++D+Wsl
  EFC37731.1 371 LEMITFQVLKGLYFLHfRKKIVHRDLKPANILIKLNGEVKISDMGLTGIFKKNNQvteggkyglrnqhvWNTCQGTIMYMSPERINEKPHSYNSDIWSL 469
                 ****************9999********************************9999************99999************************** PP

                 HHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGG CS
     Pkinase 184 GvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpy 263
                 Gv+l+el  g+ pf+    + ++   +d+   i ++   ++++  e +  se + d++k++lk+ p++R+++++ll+h +
  EFC37731.1 470 GVTLVELALGEFPFK----SGSYFDVMDE---INNV---ETKNPLEGKGYSEVFEDFIKNCLKVSPEDRYSCRDLLSHAF 539
                 ***************....4445555555...3333...34566677788****************************98 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.2   0.0     7e-35   2.1e-31       1     257 [.     276     536 ..     276     538 .. 0.81

  Alignments for each domain:
  == domain 1  score: 109.2 bits;  conditional E-value: 7e-35
                  EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCT CS
  Pkinase_Tyr   1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvctkeepllivteyvkgGdLlkfLrkkek 97 
                  le+ kklGeGa ++V   + +  + k   k +vK     a++ + + +l+e++++ ++ +  ni++l+ +   ++++ i++ey++g++L++    k  
   EFC37731.1 276 LETIKKLGEGASSTVELVKDN--TGKLYAKKIVKL----AKDIQPKLILSEITTLYNCvECSNILRLYNANFADNKINILLEYMDGNSLESLAGIK-- 365
                  567899******999877666..444444444444....45555778**********99*****************************99876555.. PP

                  TTSBHHHHHHHHHHHHHHHHHHH.HTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEE...........EETTSSTSGGGGS-HHHHHHSEEE CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLe.skklvHrdlaarNvLlsenkvvkisDfGLardiekddey...........vkkeeaklpvkWmapEslkekkft 183
                    +  + l  +++qv kG+ +L+ +kk+vHrdl   N+L++ n  vkisD GL+   +k+++            ++ ++++  + +m+pE ++ek  +
   EFC37731.1 366 --IPERILEMITFQVLKGLYFLHfRKKIVHRDLKPANILIKLNGEVKISDMGLTGIFKKNNQVteggkyglrnqHVWNTCQGTIMYMSPERINEKPHS 461
                  ..8888888899**********95677**************************9887666555333333443333445678899************** PP

                  HHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEE..S-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 184 sksDvWsfGvllwEiftlgespypglkneevleklkegkr..lekpekcpeelyelmkkcweedpeeRptfselve 257
                   +sD+Ws Gv+l E++  ge p+++ +  +v++ +++ +     + +  +e + +++k+c++ +pe+R + ++l++
   EFC37731.1 462 YNSDIWSLGVTLVELAL-GEFPFKSGSYFDVMDEINNVETknPLEGKGYSEVFEDFIKNCLKVSPEDRYSCRDLLS 536
                  **************987.**************99954433114455667888899*************99998865 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.3   8.2e-08   0.00025     281     399 ..     307     468 ..      91     469 .. 0.67

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 8.2e-08
  Pkinase_fungal 281 r..................................lenrvhrrlvispvGkpiek...aespkellealr.DaIkghrsLflkagiLHrDiSenN 337
                     +                                   +n++  +l+    G+++e     + p+++le +  +++kg+  L+  ++i+HrD    N
      EFC37731.1 307 KlakdiqpklilseittlyncvecsnilrlynanfADNKIN-ILLEYMDGNSLESlagIKIPERILEMITfQVLKGLYFLHFRKKIVHRDLKPAN 400
                     25566666666666666666666666666666663333333.44444445444431115667778877644899********************* PP

  Pkinase_fungal 338 ilitdskkegerkglLiDLDlakelsddssesga...........rertGTleFmaievlkgeeHsyrhDLES 399
                     ili       + +  ++D+ l    +++++  +            ++  GT+ +m+ e ++++ Hsy  D+ S
      EFC37731.1 401 ILIK-----LNGEVKISDMGLTGIFKKNNQVTEGgkyglrnqhvwNTCQGTIMYMSPERINEKPHSYNSDIWS 468
                     ***9.....5667789999998777754444322334444445557799************999*****9865 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   3.6       1.6   4.9e+03      11      69 ..     103     160 ..      79     170 .. 0.61
   2 ?   -2.3   0.1      0.55   1.6e+03       7      45 ..     234     272 ..     229     305 .. 0.76
   3 !   18.6   0.6   2.4e-07   0.00073     175     262 ..     329     425 ..     267     427 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 1.6
  Haspin_kinase  11 ksrssqsslkhktshssLqkfsssssessssnkislPvkdqvsrdkikkklrnseslls 69 
                     +++s++s++  + +s  +k     + ++ +n++ +P  + + ++k +kk +  + ll 
     EFC37731.1 103 ANNNSTPSFSSHMRESMGKKQIIEAKAEEIQNNVDKPKGK-IEKKKKQKKFKPTNLLLN 160
                    4455566666555555445555555555566666666544.367777777776666665 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.55
  Haspin_kinase   7 leslksrssqsslkhktshssLqkfsssssessssnkis 45 
                    les++s +++s ++++t+ + L +f+ +++ +++ +++s
     EFC37731.1 234 LESITSPTKSSRFMNQTNGANLLHFERKKHGQKKITSVS 272
                    567777888888888888888888877776666655554 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 2.4e-07
  Haspin_kinase 175 k........pdfyseqqlflvlllkdkGtdLeevklksw.kqal.sifwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRlesse 260
                    +           + ++++ ++l+    G++Le +   ++ + +l  i +q++k Ly    + +  HRdL+  niL++ n++v + d+ l  + +++
     EFC37731.1 329 EcsnilrlyNANFADNKINILLEY-MDGNSLESLAGIKIpERILeMITFQVLKGLYFLHFRKKIVHRDLKPANILIKLNGEVKISDMGLTGIFKKN 423
                    233344444556666666666665.46999*99955554155552699**************************************9988776555 PP

  Haspin_kinase 261 gk 262
                    ++
     EFC37731.1 424 NQ 425
                    55 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   3.3e-05     0.098     124     250 ..     346     483 ..     305     494 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3.3e-05
  Kinase-like 124 leilnkvlqkrsethkkletiar...lllTlqlirlaanLqa.kglvhgkftvdnllldekgglmlggftaLvragtkvvl.sevekgfaPpEllgsr 216
                  ++il + ++ +s +     +i +    ++T q+++    L++ k +vh ++++ n+l + +g +++ +++     +++ ++    + g+    + +  
   EFC37731.1 346 INILLEYMDGNSLESLAGIKIPErilEMITFQVLKGLYFLHFrKKIVHRDLKPANILIKLNGEVKISDMGLTGIFKKNNQVtEGGKYGLRNQHVWNTC 443
                  566666666666663333333330114678999998889997357*********************98765444444444415555788888887776 PP

  Kinase-like 217 gg...ytrk...nktkmthkldaWqlGlviyriwclklPl 250
                  +g   y      n+   +++ d W lG++   ++  + P+
   EFC37731.1 444 QGtimYMSPeriNEKPHSYNSDIWSLGVTLVELALGEFPF 483
                  6667775441115556899999999999998887777776 PP

>> GTA_TIM  GTA TIM-barrel-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   1.3   9.3e-05      0.28     213     275 ..      79     144 ..      60     151 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 9.3e-05
     GTA_TIM 213 elGcpavdkgtnqPnvfvDpksse...salPyfskgarddliqrralealleyweeeannpvsavy 275
                    +++ d  +n+ n  vD  ss+   + +P fs+ +r+ + +++++ea  e  +++ + p  ++ 
  EFC37731.1  79 SAMIASDDLNANNSNHSVDVNSSNannNSTPSFSSHMRESMGKKQIIEAKAEEIQNNVDKPKGKIE 144
                 4456778999***********996333689***********************9999998887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (570 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1221  (0.068102); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.73u 0.36s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 3195.78
//
Query:       EFC37732.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.9e-27   94.3   7.2    7.9e-27   94.3   7.2    2.2  2  Pkinase         Protein kinase domain
    1.2e-09   37.9   0.4    2.6e-09   36.8   0.4    1.6  1  Pkinase_Tyr     Protein tyrosine kinase
  ------ inclusion threshold ------
      0.026   13.9   0.2      0.047   13.0   0.2    1.4  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
       0.12   12.5   2.9        0.5   10.5   1.0    3.0  3  NYD-SP28_assoc  Sperm tail C-terminal domain
       0.39   11.4   3.7       0.81   10.4   2.0    2.3  2  YabA            Initiation control protein YabA


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.3   7.2   2.2e-30   7.9e-27       2     196 ..     130     345 ..     129     433 .. 0.84
   2 ?   -2.9   0.3      0.98   3.5e+03     203     240 ..     454     491 ..     445     495 .. 0.64

  Alignments for each domain:
  == domain 1  score: 94.3 bits;  conditional E-value: 2.2e-30
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HH.. CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslsee.. 98 
                   ++ lG+G+ G+ +ka++k+ ++++A+K+  +++ ++ +    ++ i+++++ + +  +++ye+   ++++y ++e+ e++ lad++ rk+++ ++  
  EFC37732.1 130 DMISVLGHGGEGVALKAFSKKINEMIAIKIKFEKEYDEVSS---RERIQFIRRNDIEGKIKCYECNLIDNYMYSIMELGEET-LADYIDRKRTVHQKqa 224
                 56789************************988888888765...7789********************************55.******8888777778 PP

                 ........HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH................TTSC CS
     Pkinase  99 ........eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl................kene 173
                         e   i++++l++++ +H+++i HrDl p+N+    k+  Ki+DF++ak ++++++ t  vg   Y++PEv                 +  +
  EFC37732.1 225 siskgiliERLTIFTKVLQAVKSIHDHNISHRDLDPKNVVKM-KEYYKIIDFDIAKVIKTGNSITLTVGKFAYMSPEVShdnyeemlldgeklahNIGN 322
                 888889888889***************************988.9**********************************988887777776555433378 PP

                 BSHHHHHHHHHHHHHHHHHSS-S CS
     Pkinase 174 yskkvDvWslGvilyelltgkpp 196
                 +++++Dv+slG++l++llt + +
  EFC37732.1 323 ITTSCDVFSLGCMLLKLLTDCSL 345
                 8*****************98876 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.98
                 HHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHH CS
     Pkinase 203 kekvekeldqlekilkilgetkeklpeaseiseeakdl 240
                 + +++k++ +l+ i +i++e+++  +e  e+++ +k+l
  EFC37732.1 454 EMDNYKDISELKDIPQIIEENEQLKHEIVELKKRVKEL 491
                 44566777777788888877666666666666666666 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.4   7.2e-13   2.6e-09       4     203 ..     132     344 ..     129     365 .. 0.84

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 7.2e-13
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT...... CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk...... 95 
                   + lG+G  G   ++  k    k ++ +a+K+  e+  +  + +  e ++++++ + +  +k++ + + ++ ++ ++e+ ++ +L +++ +k      
   EFC37732.1 132 ISVLGHGGEGVALKAFSK----KINEMIAIKIKFEKEYD--EVSSRERIQFIRRNDIEGKIKCYECNLIDNYMYSIMELGEE-TLADYIDRKrtvhqk 222
                  567888888888888887....67777888877443333..3677889999999999*99********99********9775.8*****999999875 PP

                  ..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.......... CS
  Pkinase_Tyr  96 ..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.......... 181
                    + +k  l + l + ++v ++++ ++++++ Hrdl  +Nv ++ ++  ki Df +a+ i   ++ ++ + +   + +m+pE+ +++           
   EFC37732.1 223 qaSISKGILIERLTIFTKVLQAVKSIHDHNISHRDLDPKNV-VKMKEYYKIIDFDIAKVI---KTGNSITLTVGKFAYMSPEVSHDNYeemlldgekl 316
                  55334444567789999***********************9.67799*************...44445566777899*******9998899******* PP

                  ......EEHHHHHHHHHHHHHHHHTTSS CS
  Pkinase_Tyr 182 ......ftsksDvWsfGvllwEiftlge 203
                        +t++ Dv+s G +l  ++t ++
   EFC37732.1 317 ahnignITTSCDVFSLGCMLLKLLTDCS 344
                  ********************99999775 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   1.3e-05     0.047     122     170 ..     236     279 ..     207     287 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.3e-05
         Kdo 122 allkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldkar 170
                 +++ +v ++++ +h+ ++ H+dl +kn+   +e        +iD+d a+
  EFC37732.1 236 TIFTKVLQAVKSIHDHNISHRDLDPKNVVKMKE-----YYKIIDFDIAK 279
                 56789999*******************975555.....58999999766 PP

>> NYD-SP28_assoc  Sperm tail C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.49   1.8e+03      17      37 ..      86     106 ..      84     113 .. 0.79
   2 ?   -3.0   0.0       2.4   8.5e+03      26      42 ..     304     320 ..     300     323 .. 0.79
   3 ?   10.5   1.0   0.00014       0.5      22      57 ..     452     489 ..     449     491 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.49
  NYD-SP28_assoc  17 lWdalekaLekYhevLteRak 37 
                      W+   k +e++ +vLt+ ++
      EFC37732.1  86 EWTSNAKTFEDHKQVLTKYKQ 106
                     688888889999999987665 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.4
  NYD-SP28_assoc  26 ekYhevLteRaklieet 42 
                      +Y e+L + +kl +++
      EFC37732.1 304 DNYEEMLLDGEKLAHNI 320
                     58999999988887765 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.00014
  NYD-SP28_assoc  22 ekaLekYhev..LteRaklieetesLekqNeeLrnlLk 57 
                     +k++ +Y  +  L++  ++iee+e+L+++  eL+++ k
      EFC37732.1 452 LKEMDNYKDIseLKDIPQIIEENEQLKHEIVELKKRVK 489
                     678888887666*********************99766 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.83     3e+03      22      48 ..      51      77 ..      10     108 .. 0.61
   2 ?   10.4   2.0   0.00023      0.81      20      58 ..     457     494 ..     447     498 .] 0.78

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.83
                HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        YabA 22 eeleelkeelaelleenaeLelenekl 48
                ++ +++++ ++++  + ++L+   +++
  EFC37732.1 51 TNYSKIRTIIQDISSKFETLNYFTKEI 77
                233444444444444444444444444 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00023
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXXXXX CS
        YabA  20 lleeleelkeelaelleenaeLeleneklrerleeeekk 58 
                  +++++elk+ + +++een++L+ e  +l++r++e e+k
  EFC37732.1 457 NYKDISELKD-IPQIIEENEQLKHEIVELKKRVKELEEK 494
                 4678889885.899******************9765554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1622  (0.090468); expected 358.6 (0.02)
Passed bias filter:                      681  (0.0379832); expected 358.6 (0.02)
Passed Vit filter:                        91  (0.00507558); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.79u 0.38s 00:00:01.17 Elapsed: 00:00:00.56
# Mc/sec: 2685.91
//
Query:       EFC37733.1  [L=145]
Description: hypothetical protein NAEGRDRAFT_81849 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-46  155.7   0.2    9.8e-17   60.4   0.0    3.1  3  DUF4116          Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.063   13.4   0.0       0.15   12.3   0.0    1.6  2  DP-EP            DP-EP family
       0.11   12.8   0.0       0.22   11.8   0.0    1.7  1  RNA_pol_Rpb2_45  RNA polymerase beta subunit external 1 domai


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   0.0   1.5e-12   8.9e-09      14      48 ..       3      37 ..       2      38 .. 0.92
   2 !   57.4   0.0   1.5e-19   8.9e-16       1      49 []      40      88 ..      40      88 .. 0.99
   3 !   60.4   0.0   1.6e-20   9.8e-17       1      41 [.     104     144 ..     104     145 .] 0.97

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 1.5e-12
     DUF4116 14 salkylseeLknDkeivlkAvkqngtalsyaseeL 48
                ++lk+++e+Lk+D+eivl+Avkq g+a++  +e++
  EFC37733.1  3 WHLKFVDESLKQDREIVLEAVKQIGSAIELTDESF 37
                58*************************99888876 PP

  == domain 2  score: 57.4 bits;  conditional E-value: 1.5e-19
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                DrE++l++vk+n s+l +++ +Lk+D+eivl+A+kqn  a+ ya+e+L+
  EFC37733.1 40 DREFILQVVKHNESVLVFADRSLKRDREIVLQAIKQNRVAIGYADESLQ 88
                9*********************************************996 PP

  == domain 3  score: 60.4 bits;  conditional E-value: 1.6e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 DrE+vleavk++g+alky++e+L++D+eivl+Av qng a+
  EFC37733.1 104 DREFVLEAVKQDGLALKYADESLRRDREIVLQAVLQNGLAI 144
                 9*************************************886 PP

>> DP-EP  DP-EP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.08   4.8e+02      56      94 ..      26      68 ..       6      73 .. 0.49
   2 ?   12.3   0.0   2.5e-05      0.15      15     102 ..      52     140 ..      41     143 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.08
                EEEEES.STTSSSSXEE.EE...XTTSSEEEEEESSX.SXEEE CS
       DP-EP 56 vgaaie.tedDgnndivlsl...sengktlvlidkdkdsdesi 94
                 g aie t++ +++d ++ l   ++n++ lv+ d + + d +i
  EFC37733.1 26 IGSAIElTDESFKRDREFILqvvKHNESVLVFADRSLKRDREI 68
                3334443444433333322111155555566666666555555 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.5e-05
                 EE.EEEEXTTSBEEXSXEEES....SSEEEEEEEEEXSSSXXEEEEEEESSTTSSSSXEE.EEXTTSSEEEEEESSX.SXEEEEEEEEEEX CS
       DP-EP  15 PvafvfadssttvddgsvtVt...esavdiiyvltdesakglafvgaaietedDgnndivlslsengktlvlidkdkdsdesigfklvlaa 102
                 + + vfad+s + d + v ++   ++ v+i y +++ +++g ++ + +i+   D++  ++  ++++g  l + d++ + d +i ++ vl++
  EFC37733.1  52 ESVLVFADRSLKRDREIV-LQaikQNRVAIGYADESLQKDGGFLLESGIKSRTDREFVLE-AVKQDGLALKYADESLRRDREIVLQAVLQN 140
                 344789998777766655.33455999***********************8888777666.77***********************99876 PP

>> RNA_pol_Rpb2_45  RNA polymerase beta subunit external 1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   3.7e-05      0.22      15      53 ..      70     109 ..      46     123 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.7e-05
                      EEHHHHTTSEEE-SSS-BETTSCBS.SSEEEEECSSCEEE CS
  RNA_pol_Rpb2_45  15 LtAdeEekyviAqAnapldeegrfv.eerVlaRrkgevel 53 
                      L+A + ++  i  A++ l+++g f+ e  ++ R++ e++l
       EFC37733.1  70 LQAIKQNRVAIGYADESLQKDGGFLlESGIKSRTDREFVL 109
                      89999*******************96788****9999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (145 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       506  (0.0282224); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 876.83
//
Query:       EFC37734.1  [L=489]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-14   52.7  28.0    0.00016   21.5   0.0   11.1 11  LRR_6     Leucine Rich repeat
    1.9e-10   40.8  35.4      0.096   13.1   0.8    7.8  8  LRR_4     Leucine Rich repeats (2 copies)
     0.0098   15.8  10.3       0.46   10.4   0.3    4.1  4  DUF4957   Domain of unknown function (DUF4957)
  ------ inclusion threshold ------
      0.024   14.4  31.0       0.21   11.4   0.2    7.6  7  LRR_8     Leucine rich repeat
      0.074   13.6  25.3        6.9    7.6   0.1    8.7  9  LRR_1     Leucine Rich Repeat
        5.6    7.2   9.3        6.1    7.1   0.0    3.7  4  E7R       Viral Protein E7


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.1     0.022        66      10      21 ..     127     138 ..     126     140 .. 0.82
   2 !    8.7   0.1   0.00064       1.9       4      23 ..     180     199 ..     179     200 .. 0.92
   3 ?   -1.1   0.0      0.88   2.6e+03       3      14 ..     206     217 ..     206     219 .. 0.85
   4 !   21.5   0.0   5.3e-08   0.00016       3      23 ..     236     256 ..     236     257 .. 0.91
   5 ?    1.4   0.0      0.15   4.4e+02       4      24 .]     263     283 ..     262     283 .. 0.90
   6 !    6.2   0.0    0.0043        13       4      16 ..     315     327 ..     313     334 .. 0.83
   7 ?   -1.4   0.6       1.2   3.4e+03       3      15 ..     340     352 ..     338     357 .. 0.87
   8 !    9.4   0.1   0.00038       1.1       2      15 ..     366     379 ..     365     382 .. 0.90
   9 ?    4.1   0.0      0.02        59       3      16 ..     419     432 ..     417     434 .. 0.86
  10 !    5.4   0.0    0.0074        22       3      17 ..     444     458 ..     444     461 .. 0.93
  11 ?    2.3   0.0     0.073   2.2e+02       2      15 ..     466     479 ..     465     480 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.022
       LRR_6  10 LsgNdIgDeGae 21 
                 L  N++gDeG+ 
  EFC37734.1 127 LELNGVGDEGVD 138
                 568*******96 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00064
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +L+ LdL+ N +g +G++ L
  EFC37734.1 180 NLKILDLRKNMLGVAGLKQL 199
                 8****************998 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.88
       LRR_6   3 thLteLdLsgNd 14 
                 ++Lt+L L+ ++
  EFC37734.1 206 PNLTSLILKECH 217
                 58****999885 PP

  == domain 4  score: 21.5 bits;  conditional E-value: 5.3e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 +++t+LdLs ++IgD+G++ +
  EFC37734.1 236 SSMTYLDLSLCKIGDDGVKFI 256
                 589***************976 PP

  == domain 5  score: 1.4 bits;  conditional E-value: 0.15
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L+ ++L+ N Ig  G++ +a
  EFC37734.1 263 SLKQVNLNTNYIGVNGCKYIA 283
                 89**************99887 PP

  == domain 6  score: 6.2 bits;  conditional E-value: 0.0043
       LRR_6   4 hLteLdLsgNdIg 16 
                 +L++L+L  N Ig
  EFC37734.1 315 KLKYLNLEKNRIG 327
                 8***********8 PP

  == domain 7  score: -1.4 bits;  conditional E-value: 1.2
       LRR_6   3 thLteLdLsgNdI 15 
                  h+++L L+ +++
  EFC37734.1 340 EHIETLILNNCGL 352
                 5999****99986 PP

  == domain 8  score: 9.4 bits;  conditional E-value: 0.00038
       LRR_6   2 nthLteLdLsgNdI 15 
                 n++Lt+Ld+ +N +
  EFC37734.1 366 NSTLTYLDIGSNSL 379
                 9***********76 PP

  == domain 9  score: 4.1 bits;  conditional E-value: 0.02
       LRR_6   3 thLteLdLsgNdIg 16 
                 +++++ dLs+N ++
  EFC37734.1 419 PSIQSIDLSYNTLT 432
                 6899*******998 PP

  == domain 10  score: 5.4 bits;  conditional E-value: 0.0074
       LRR_6   3 thLteLdLsgNdIgD 17 
                 ++L+ L+L++ +I+D
  EFC37734.1 444 STLEFLNLRSTGITD 458
                 69************9 PP

  == domain 11  score: 2.3 bits;  conditional E-value: 0.073
       LRR_6   2 nthLteLdLsgNdI 15 
                 +++++++d+s N +
  EFC37734.1 466 KSKIKTVDISENRL 479
                 6899********87 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1      0.05   1.5e+02      22      36 ..     146     161 ..     118     177 .. 0.67
   2 !   10.2   0.9   0.00026      0.78       3      33 ..     149     189 ..     148     192 .. 0.80
   3 !   13.1   0.8   3.2e-05     0.096       2      30 ..     180     213 ..     179     225 .. 0.82
   4 !    7.2   0.3    0.0025       7.4       3      36 ..     238     274 ..     233     277 .. 0.78
   5 !    9.4   1.7   0.00048       1.4       2      33 ..     315     349 ..     315     353 .. 0.77
   6 !   10.2   0.4   0.00027      0.79       3      30 ..     369     396 ..     367     405 .. 0.78
   7 !    6.0   0.1    0.0056        17      21      36 ..     417     432 ..     402     440 .. 0.73
   8 !   12.3   0.3   5.8e-05      0.17       3      36 ..     446     479 ..     444     484 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.05
                 -TT--EEE-.-.S--- CS
       LRR_4  22 lpnLkeLdLsg.Nnli 36 
                 l +LkeL Ls  N++i
  EFC37734.1 146 LLDLKELCLSAdNTKI 161
                 6666666664435554 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00026
                 --EEE--.SS-..........--E-S-HHH-TT--EEE-.-S CS
       LRR_4   3 LevLdLs.nNq..........ltdiplleklpnLkeLdLsgN 33 
                 L++L+Ls +N           +++++ l+ + nLk LdL  N
  EFC37734.1 149 LKELCLSaDNTkisqritqegISKLDTLK-FNNLKILDLRKN 189
                 89999**9775577777777788888888.********9555 PP

  == domain 3  score: 13.1 bits;  conditional E-value: 3.2e-05
                 S--EEE--SS---E-S-...HH..H-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl...le..klpnLkeLdL 30 
                 nL++LdL+ N+l   +l   ++  ++pnL++L L
  EFC37734.1 180 NLKILDLRKNMLGVAGLkqlFQsqSFPNLTSLIL 213
                 9**********99888877644747*******77 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0025
                 --EEE--SS---E-S-...HH.H-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdipl...le.klpnLkeLdLsgNnli 36 
                  ++LdLs +++ d +    ++ k  +Lk+++L+ N +i
  EFC37734.1 238 MTYLDLSLCKIGDDGVkfiFSqKWNSLKQVNLNTN-YI 274
                 689****99***74448775535999******555.77 PP

  == domain 5  score: 9.4 bits;  conditional E-value: 0.00048
                 S--EEE--SS---.E-S-HHH-TT--EEE...-.-S CS
       LRR_4   2 nLevLdLsnNqlt.diplleklpnLkeLd...LsgN 33 
                 +L++L+L  N++   ++ l k +nL+++    L +N
  EFC37734.1 315 KLKYLNLEKNRIGkGVEHLCKSKNLEHIEtliL-NN 349
                 79***********88888887777777654436.33 PP

  == domain 6  score: 10.2 bits;  conditional E-value: 0.00027
                 --EEE--SS---E-S-.HHH-TT--EEE- CS
       LRR_4   3 LevLdLsnNqltdipl.leklpnLkeLdL 30 
                 L++Ld+++N l+   l +++l++Lk+L L
  EFC37734.1 369 LTYLDIGSNSLKLERLfCGSLTSLKTL-L 396
                 9***********54454446*******.8 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.0056
                 H-TT--EEE-.-S--- CS
       LRR_4  21 klpnLkeLdLsgNnli 36 
                  lp+ +++dLs N+l 
  EFC37734.1 417 ALPSIQSIDLSYNTLT 432
                 4889999999888333 PP

  == domain 8  score: 12.3 bits;  conditional E-value: 5.8e-05
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 Le+L+L+++ +td +   l+   + k++d+s+N ++
  EFC37734.1 446 LEFLNLRSTGITDQEVilLQ-KSKIKTVDISEN-RL 479
                 9***************8444.688******999.44 PP

>> DUF4957  Domain of unknown function (DUF4957)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.3   0.00015      0.46      37     100 ..     141     202 ..     135     219 .. 0.85
   2 ?    2.5   0.3     0.042   1.3e+02      56     114 ..     224     280 ..     207     296 .. 0.78
   3 ?    2.0   0.3     0.061   1.8e+02      42     113 ..     313     357 ..     277     371 .. 0.55
   4 !    5.1   0.0    0.0067        20      36     100 ..     411     471 ..     400     485 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00015
     DUF4957  37 istgasLkiknldldgsasdssfialsetpdetikdtltiqnCeikdvnkgliydnnkkyvies 100
                 i+ ++ L++k+l l++++++ s + ++++  +++ dtl+++n +i d++k+++ +   k+  +s
  EFC37734.1 141 IKHKKLLDLKELCLSADNTKIS-QRITQEGISKL-DTLKFNNLKILDLRKNMLGVAGLKQLFQS 202
                 778889*********9887766.9***9999999.*****************998776776665 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.042
     DUF4957  56 dssfialsetpdetikdtltiqnCeikdvnkgliydnnkkyviesivinnclvkniess 114
                 d++f +++  + +++   l ++ C+i d + ++i+  +    ++++ +n +++  ++++
  EFC37734.1 224 DEAFKSFNSDNFSSM-TYLDLSLCKIGDDGVKFIFSQK-WNSLKQVNLNTNYIGVNGCK 280
                 445555555555555.899****************998.89999999999999888885 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.061
     DUF4957  42 sLkiknldldgsasdssfialsetpdetikdtltiqnCeikdvnkgliydnnkkyviesivinnclvknies 113
                 s+k+k l+l                          ++ +i    ++l    n    ie++++nnc  +   +
  EFC37734.1 313 SFKLKYLNL--------------------------EKNRIGKGVEHLCKSKN-LEHIETLILNNCGLHHSAC 357
                 334444444..........................44444333333333333.4556666666666666555 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0067
     DUF4957  36 sistgasL.kiknldldgsasdssfialsetpdetikdtltiqnCeikdvnkgliydnnkkyvies 100
                  i+++ +L +i+++dl+ +  +s+fi+   +p +t+ + l +++  i+d +  l+  ++    i++
  EFC37734.1 411 PIRRSEALpSIQSIDLSYNTLTSNFIEWLSEPFSTL-EFLNLRSTGITDQEVILLQKSK----IKT 471
                 56666666589*************************.6667777777666665555444....333 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   2.0     0.013        38      24      56 ..     178     213 ..     164     217 .. 0.63
   2 ?    1.3   0.2     0.097   2.9e+02       1      33 [.     206     244 ..     206     249 .. 0.56
   3 ?    1.4   0.3     0.093   2.8e+02       4      37 ..     239     274 ..     236     276 .. 0.68
   4 ?    4.2   0.8     0.012        36      26      40 ..     315     329 ..     313     352 .. 0.57
   5 ?    7.2   1.9    0.0014       4.3       8      54 ..     352     395 ..     340     399 .. 0.69
   6 ?   11.4   0.2   7.1e-05      0.21      11      59 ..     404     454 ..     400     456 .. 0.75
   7 ?    2.7   0.2     0.037   1.1e+02       2      39 ..     445     481 ..     444     487 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.013
                 -TT--EEE--SS---GGGGGGG...TT--S-.EEE- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgaf...sgLpsLrsLdL 56 
                 ++nLk+LdL+ N l +   + +   +++p+L+sL L
  EFC37734.1 178 FNNLKILDLRKNMLGVAGLKQLfqsQSFPNLTSLIL 213
                 468999999999886644333312234555555555 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.097
                 TT-SEEE-TTS-.-SEE-TTSST.....T-TT--EEE-- CS
       LRR_8   1 pnLtsLdLsnNr.ltslddeaFk.....glsnLkvLdLs 33 
                 pnLtsL+L   + +++  deaFk     ++s++++LdLs
  EFC37734.1 206 PNLTSLILKECHkFEKRLDEAFKsfnsdNFSSMTYLDLS 244
                 577777777766666666666662222123455555555 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.093
                 SEEE-TTS--SEE-TTSSTT..-TT--EEE--SS-- CS
       LRR_8   4 tsLdLsnNrltslddeaFkg..lsnLkvLdLsnNll 37 
                 t+LdLs  ++ + + ++ ++  +++Lk  +L+ N +
  EFC37734.1 239 TYLDLSLCKIGDDGVKFIFSqkWNSLKQVNLNTNYI 274
                 666666666666666654443689999999999987 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.012
                 T--EEE--SS---GG CS
       LRR_8  26 nLkvLdLsnNllttl 40 
                 +Lk+L+L  N++   
  EFC37734.1 315 KLKYLNLEKNRIGKG 329
                 578888888887663 PP

  == domain 5  score: 7.2 bits;  conditional E-value: 0.0014
                 -TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8   8 LsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsL 54 
                 L+++  +++  +aF+  s L++Ld+++N+l+   +  + +L+sL+ L
  EFC37734.1 352 LHHSACEHIVNSAFN--STLTYLDIGSNSLKLE-RLFCGSLTSLKTL 395
                 566667778888888..8**********88753.1223345555555 PP

  == domain 6  score: 11.4 bits;  conditional E-value: 7.1e-05
                 S-.-SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS CS
       LRR_8  11 Nr.ltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgN 59 
                 N+ +++++    + l++ +++dLs+N+lt+ + +   + ++ L++L+L+++
  EFC37734.1 404 NYvFENVPIRRSEALPSIQSIDLSYNTLTSnFIEWLSEPFSTLEFLNLRST 454
                 555666666666789*************99655566667888999999876 PP

  == domain 7  score: 2.7 bits;  conditional E-value: 0.037
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt 39 
                 +L+ L+L+++ +t+ +    ++ s+ k+ d+s+N+l+ 
  EFC37734.1 445 TLEFLNLRSTGITDQEVILLQK-SKIKTVDISENRLDL 481
                 6778999999999999999996.999999999999976 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.3    0.0089        26       1      21 [.     180     206 ..     180     230 .. 0.81
   2 ?   -0.5   0.0       1.1   3.3e+03       3      13 ..     239     249 ..     237     260 .. 0.79
   3 ?   -2.9   0.1         6   1.8e+04       1      12 [.     263     274 ..     261     281 .. 0.72
   4 ?   -3.2   0.0         6   1.8e+04       3      10 ..     291     298 ..     289     303 .. 0.71
   5 ?    7.6   0.1    0.0023       6.9       1      21 [.     315     334 ..     315     337 .. 0.86
   6 ?    1.8   0.4      0.19   5.8e+02       2      17 ..     342     362 ..     338     367 .. 0.62
   7 ?    5.9   0.2    0.0088        26       2      16 ..     369     388 ..     368     396 .. 0.70
   8 ?    2.6   0.3      0.11   3.2e+02       2      15 ..     421     434 ..     420     465 .. 0.73
   9 ?   -0.5   0.0       1.1   3.2e+03       1      12 [.     468     479 ..     468     484 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0089
       LRR_1   1 nLrhLdLsnnpl......lglppnsfq 21 
                 nL+ LdL+ n l        ++++sf 
  EFC37734.1 180 NLKILDLRKNMLgvaglkQLFQSQSFP 206
                 8*********99777776334555554 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1   3 rhLdLsnnpll 13 
                 ++LdLs + ++
  EFC37734.1 239 TYLDLSLCKIG 249
                 68****99885 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 6
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+  +L+ n +
  EFC37734.1 263 SLKQVNLNTNYI 274
                 577788877765 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 6
       LRR_1   3 rhLdLsnn 10 
                 +hL L+ +
  EFC37734.1 291 EHLELGCQ 298
                 89999655 PP

  == domain 5  score: 7.6 bits;  conditional E-value: 0.0023
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L+L+ n++ g++ ++++
  EFC37734.1 315 KLKYLNLEKNRI-GKGVEHLC 334
                 7**********9.78887776 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.19
       LRR_1   2 LrhLdLsnnpl.....lglpp 17 
                  ++L L+n+ l     +++ +
  EFC37734.1 342 IETLILNNCGLhhsacEHIVN 362
                 3556699*9996666555555 PP

  == domain 7  score: 5.9 bits;  conditional E-value: 0.0088
       LRR_1   2 LrhLdLsnnpl.....lglp 16 
                 L++Ld+++n+l     ++ +
  EFC37734.1 369 LTYLDIGSNSLklerlFCGS 388
                 99********8664444444 PP

  == domain 8  score: 2.6 bits;  conditional E-value: 0.11
       LRR_1   2 LrhLdLsnnpllgl 15 
                  +++dLs+n l++ 
  EFC37734.1 421 IQSIDLSYNTLTSN 434
                 57899999988433 PP

  == domain 9  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1   1 nLrhLdLsnnpl 12 
                 + ++ d+s n+l
  EFC37734.1 468 KIKTVDISENRL 479
                 57999*****98 PP

>> E7R  Viral Protein E7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.021        64      21      33 ..     171     183 ..     167     190 .. 0.87
   2 ?   -3.6   0.3       4.6   1.4e+04       8      14 ..     274     280 ..     271     281 .. 0.81
   3 ?   -0.5   0.2      0.49   1.5e+03      20      50 ..     339     369 ..     333     374 .. 0.70
   4 ?    7.1   0.0    0.0021       6.1       9      33 ..     427     453 ..     421     457 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.021
         E7R  21 eqlstlnfnnlrv 33 
                  +l tl fnnl++
  EFC37734.1 171 SKLDTLKFNNLKI 183
                 5799*******97 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 4.6
         E7R   8 itynGck 14 
                 i  nGck
  EFC37734.1 274 IGVNGCK 280
                 778***9 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.49
         E7R  20 leqlstlnfnnlrvwnscsiGnvtrlfytff 50 
                 le + tl +nn     s     v   f + +
  EFC37734.1 339 LEHIETLILNNCGLHHSACEHIVNSAFNSTL 369
                 89999*****988877766555555555555 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0021
         E7R   9 tynGckdn..kwmleqlstlnfnnlrv 33 
                 +yn    n  +w+ e +stl+f nlr 
  EFC37734.1 427 SYNTLTSNfiEWLSEPFSTLEFLNLRS 453
                 57776666569**************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       514  (0.0286686); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 2886.70
//
Query:       EFC37735.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       700  (0.0390429); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.42
# Mc/sec: 1950.47
//
Query:       EFC37736.1  [L=292]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (292 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1071  (0.0597356); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 2000.69
//
Query:       EFC37737.1  [L=1043]
Description: phosphatidylinositol-4-phosphate 5-kinase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-54  183.3   7.3    1.6e-53  181.7   7.3    1.8  1  PIP5K     Phosphatidylinositol-4-phosphate 5-Kinase
  ------ inclusion threshold ------
       0.19   11.0  13.1       0.34   10.2  13.1    1.4  1  7tm_2     7 transmembrane receptor (Secretin family)


Domain annotation for each model (and alignments):
>> PIP5K  Phosphatidylinositol-4-phosphate 5-Kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.7   7.3   1.8e-57   1.6e-53       6     270 ..     664     949 ..     660     952 .. 0.83

  Alignments for each domain:
  == domain 1  score: 181.7 bits;  conditional E-value: 1.8e-57
                 EEE----SSS--EEEETTSSEEEEEE-HHHHHHHHHHHHHHHHHHTT-TT--S--EEEEEEEE.ETTEEEEEEEEE-SS-...........TTS--SEE CS
       PIP5K   6 kelsseGkSgsffylteDkkfiiKtitksevkflrkllpeYyehvkenpnsLltrfyglhrvklkggkkvrfvVmenlfp...........tdkeiher 93 
                 ++  seGkSgsff +t D++f+iKti+ +e k+l++ ++ +y+h ++ +++++++++g++++k++ + k++f+V++n ++            ++++  +
  EFC37737.1 664 RNNFSEGKSGSFFLFTYDSQFMIKTINDDELKLLLDNIQFFYKHYTTFRDTFIVKIFGIYELKMTANFKIKFIVINNALNcrlakdrgaqyDPMSVYTK 762
                 56679************************************************************************99988876665443333666** PP

                 EEE-S--TT-S--HHHHTSSS-E......................EEHHHHHHHST.EEE-HHHHHHHHHHHHHHHHHHHHTTB-S-EEEEEEEB---- CS
       PIP5K  94 yDLKGstvgReakkkeeekkekt......................lkDlDliekkeklklgkekreelleqlekDvefLeslnimDYSLLlGihnseke 170
                 +DLKGs+++R+  ++ +  +++                       l D+D+++k++ +  +k  +e++ +ql+ D++fL+sl+imDYSLLlG+ + + +
  EFC37737.1 763 FDLKGSWINRNNLPTFDGYANTLkfkstsnaedayashvqnrnklLLDNDFTRKRKIIFENKAIYERFKQQLTIDSNFLKSLKIMDYSLLLGLAEDDPA 861
                 **********99976663333335666677889999999999999*********8777779999*****************************665544 PP

                 ----------------------------------------SEEEEESSSSEEEEEEEEE----B--------------..--------TTHHHHHHHHH CS
       PIP5K 171 ekeekkesessssekesekseeeaseeeeeseeeedeegekakeensedgkevyylgiIDiLqkynlkKklehalksl..kkdkksisavpPkeYaeRF 267
                   + ++  ++               +  e  +++ + + + +  ++  +   ++y ++IDiLq y+++Kk+e+++k+   +kd++ is v+P +YaeRF
  EFC37737.1 862 VISVESLPNE--------------IKFYEPFHKTYKGGIQVIDLDSPYNRAAIMYSSVIDILQLYDMNKKMETLIKTKilRKDPNGISSVEPISYAERF 946
                 4332222222..............2223344444455555566666678889************************9889******************* PP

                 HHH CS
       PIP5K 268 lkf 270
                 ++ 
  EFC37737.1 947 QNN 949
                 986 PP

>> 7tm_2  7 transmembrane receptor (Secretin family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2  13.1   3.8e-05      0.34       5     183 ..     158     335 ..     154     381 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 3.8e-05
                 HHHHHHHHHHHHHHHHHHHHHHHTTTGTTSHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       7tm_2   5 kvittvGlslSlvaLlvallilllfrklrctrnyihlnLflslllrailvlvkdavlkseedeseaevekvgCkvvavflhYfllanffWllvEglyly 103
                 +++++v  +lS+++ ++ ++ ++ + +lr  +n+    L++++l+ ++l  vk   +    +  e+  e   C vva+f   f  ++++  ++  l l 
  EFC37737.1 158 SYFELVFAALSFCFCIILMVAFVGLAELRGRKNF---ALIMAFLATEALSCVKHFLILLILHFPETIYEPNMCIVVAIFEYGFNFCSYCYGFCIVLDLL 253
                 6778899999*******************99997...57788888888888887777776777888899999****99988899*************** PP

                 HHHHT-XXSHHHCHHHHHHHHTHHHHHHHHHHHHH.HHHHS-SSSS---SS.TCTHTTCHHHHHHHHHHHHHHHHHHHHHHH CS
       7tm_2 104 tllveaffserkylkkylliGwGvPavvvavwavv.kaylederCWlsnee.kllwiikgPvlliilvNfilfinivrvlvq 183
                 ++ ++ ++ ++k+  +y++  w + ++ ++ ++v    + +++ C +  +e ++ ++i g   ++ ++ + + + +   l +
  EFC37737.1 254 NVATNPIKGNKKKHIMYHICMWTLTILAIVGSVVEsTLTQNNQACSILPDElYIGYAIYGINGIMAIIGIGICLYVWSSLRR 335
                 **************************999999988788889999*9999998888888886554444444454444455554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1043 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1078  (0.0601261); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.85u 0.32s 00:00:01.17 Elapsed: 00:00:00.52
# Mc/sec: 6069.85
//
Query:       EFC37738.1  [L=1870]
Description: hypothetical protein NAEGRDRAFT_53564 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.7e-18   64.9   0.0    1.4e-17   63.9   0.0    1.5  1  G8          G8 domain
  ------ inclusion threshold ------
       0.18   11.7  15.4       0.58   10.0   0.6    3.8  3  Beta_helix  Right handed beta helix region


Domain annotation for each model (and alignments):
>> G8  G8 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.9   0.0   1.6e-21   1.4e-17      14     123 .]     629     745 ..     621     745 .. 0.88

  Alignments for each domain:
  == domain 1  score: 63.9 bits;  conditional E-value: 1.6e-21
          G8  14 vvIpagktvlld.vsspklrsllve..GtLifsddksdielnaeyilvqggGkleiGteeepfkgkatItLyG......teewsstelpdlgaKvlavs 103
                   I+ +k v +d + + klrs++v   G+Lif d+ ++++l+++yi v++g+++++G+ ++p+++k+ +t+yG      +   ++ ++ ++g+K+++  
  EFC37738.1 629 SQITINKAVKVDkSPPYKLRSITVLsgGSLIF-DN-ANLTLHVDYIRVESGASWIMGSATCPITNKIILTFYGsrttesEIGIDPFDNVNMGSKGIGFL 725
                 446668899999455557******9*******.88.9************************************887766556667779*********** PP

          G8 104 ngGtlelhGqprkktwtkLa 123
                 +g +++++Gq  ++t t La
  EFC37738.1 726 SGSKVQIFGQVDSPTFTDLA 745
                 *****************996 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.6   6.5e-05      0.58       9     109 ..     868     963 ..     845    1011 .. 0.80
   2 ?    7.0   4.1   0.00053       4.7      12     144 ..    1074    1214 ..    1062    1232 .. 0.66
   3 ?   -0.7   0.1      0.13   1.2e+03     121     149 ..    1592    1622 ..    1561    1637 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 6.5e-05
                 -E.EEESEEEES-SS-SEEE-SSS-..EEES-EEES-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-TT-S-..-E CS
  Beta_helix   9 snvtiknntisnsggyGiylrgssn.vvienneiannsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdnggsGiylnyssn..nt 104
                 +++++++ +i++ g+yG++ r s + +++e n+ +n s++G   +      i++++++d+ +    + ++++ l+e+n +++  g+ ++l++ s   n+
  EFC37738.1 868 TQFQVEGIEIRKFGQYGLMGRYSFHlHLLE-NTAQN-STFGTQYY------IRGCSVHDSFQRCYVVHDTNYFLLEDNVCFNAIGHEYFLEDGSElgNV 958
                 567899999999999999999998845555.88888.77777776......99********8999999***************9999999985555677 PP

                 EES-E CS
  Beta_helix 105 ienNi 109
                 +++N 
  EFC37738.1 959 FKHNL 963
                 77774 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.00053
                  EEESEEEES-SS-SEEE-SSS-.EEES-EEES............-SS-SEEE-TT.........-S-EEES-EEE---SEEE-TT--S--EEES-EE CS
  Beta_helix   12 tiknntisnsggyGiylrgssnvvienneian............nsgsGiyilgs.........snntisnntisdnngggialfgasnnliennei 87  
                   i+n+t ++  +yGi++r ++  v++n ++++              ++      s          + t++ n+  +n  +  +l+++  ++i++ e 
  EFC37738.1 1074 LIDNFTAYKLRNYGIWARCGNI-VFKNLYLTDnmrqmnsppgtsYITD------SimigesdniGDYTLRPNVDKGNR-TRPNLYASTTVVIKGYET 1162
                  699**************99998.****999996666643333222222......234444466666677777777777.****************** PP

                  ES-SS-SEE-TT-S--EEES-EEESTT...--SEE---TT---EEES-EEES-SSEEEE- CS
  Beta_helix   88 tdnggsGiylnyssnntienNiidnna...gsGividdsssnvtvtnNtitnnkgaGiav 144 
                  +dngg+ +      n+t++n + d  +   gs   + +++ ++  ++N + +n  +G+++
  EFC37738.1 1163 YDNGGAEL----LRNVTFRNFVTDQYRradGSITGVAAGA-WI--SGNDAIQNF-EGCEI 1214
                  ***98644....3455655544444444332333333333.44..555555555.44433 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.13
                  --TT..---EEES-EEES-SSEEEE-TT-SS CS
  Beta_helix  121 ddss..snvtvtnNtitnnkgaGiavvgsss 149 
                  ++ +  s+ t +   +++n+g G +vv++ s
  EFC37738.1 1592 YNDGdpSKSTGFTAQVYSNSGSGDYVVSNTS 1622
                  3333365555566666666666666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1870 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       522  (0.0291148); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.07u 0.33s 00:00:01.40 Elapsed: 00:00:00.57
# Mc/sec: 9800.52
//
Query:       EFC37739.1  [L=1029]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1029 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1154  (0.064365); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.85u 0.31s 00:00:01.15 Elapsed: 00:00:00.50
# Mc/sec: 6220.45
//
Query:       EFC37740.1  [L=311]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-15   57.8   6.0    1.1e-15   57.8   6.0    3.2  3  CPBP      CPBP intramembrane metalloprotease
  ------ inclusion threshold ------
        0.1   12.1   0.1       0.22   11.0   0.1    1.5  1  Spo7      Spo7-like protein
       0.11   13.0   0.1       0.11   13.0   0.1    3.9  3  FtsX      FtsX-like permease family
       0.44   10.8  11.0       0.12   12.6   3.2    2.6  2  DUF1761   Protein of unknown function (DUF1761)
        3.9    7.4   9.5          1    9.3   0.1    3.1  4  DUF418    Protein of unknown function (DUF418)


Domain annotation for each model (and alignments):
>> CPBP  CPBP intramembrane metalloprotease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   2.5      0.76   2.7e+03      77      77 ..      68      68 ..       5     109 .. 0.53
   2 ?   -0.3   0.5      0.39   1.4e+03      10      21 ..     104     115 ..      85     117 .. 0.60
   3 !   57.8   6.0   3.1e-19   1.1e-15       6      90 ..     170     275 ..     165     277 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.76
                T CS
        CPBP 77 g 77
                g
  EFC37740.1 68 G 68
                1 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.39
                 HHHHHHHHHHHH CS
        CPBP  10 lalllapllEEl 21 
                   l+l+p++EEl
  EFC37740.1 104 TCLFLGPIAEEL 115
                 255677777776 PP

  == domain 3  score: 57.8 bits;  conditional E-value: 3.1e-19
                 HHHHHHHHHHHHHHHHHHTTCHHHHHHHH.S-..HHHHHHHHHHHHHCSGGG...................HHHHHHHHHHHHHHHHHHHHTT-HHHHH CS
        CPBP   6 lvfllalllapllEEllfRglllqllqergss..tlailissilFglaHlpn...................gpsvllaalaGlvlgylylktgsllaai 83 
                 l+ ++a++++pl+EE++fR +l  ll  +g+   + ++li+ +lFg+ H ++                    +++ +++++G+++gy+y kt  +laai
  EFC37740.1 170 LFSFRAIVMGPLTEEIVFRTCLHYLLYYYGGIslLSSLLIACLLFGVCHCHHiiehvvhgqmsitsalinvIVQFTYTSVFGFYCGYIYAKTSCILAAI 268
                 67899*********************9994446699999*************99888888888888888665558************************ PP

                 HHHHHHH CS
        CPBP  84 llHalln 90 
                 llHa +n
  EFC37740.1 269 LLHAYCN 275
                 ******9 PP

>> Spo7  Spo7-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1     6e-05      0.22      23      82 ..      39      99 ..      29     111 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 6e-05
        Spo7 23 elrarrrkytlflllLalviafflyalflapredgsgvggsvywvvevve.kvlliggvvT 82
                  + rrr   ++l+ L+ +i  +l  lf+ ++e+++++g  + + +++++ ++ +++++++
  EFC37740.1 39 PSQVRRRSISVLLSSLVSIIYSCLVYLFFGNHESHQEMGLLSSMGFNFAQiHYQILAIIIA 99
                5689*************************99999888885544444443312223333333 PP

>> FtsX  FtsX-like permease family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.2      0.15   5.2e+02      24      78 ..       7      63 ..       4      68 .. 0.49
   2 ?   13.0   0.1   3.1e-05      0.11       2      31 ..      74     103 ..      73     141 .. 0.90
   3 ?   -5.6  12.2         5   1.8e+04      29      82 ..     248     304 ..     167     311 .] 0.57

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.15
        FtsX 24 eillitlvalviGlglgllaaqllsdvllssvfs..selkisidlitvliiivllll 78
                eil+++    +++l +g+l+ +  s   + +  s   + +is+ l++++ ii  +l+
  EFC37740.1  7 EILAVIHAIVLSALYVGSLYMWDGSLAKSRNEPSqvRRRSISVLLSSLVSIIYSCLV 63
                555555555666666666665542222222222234555555555555555555544 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 3.1e-05
        FtsX   2 reigilralGmkkkqvlllllteillitlv 31 
                 +e+g+l ++G++ +q+  ++l  i++i+l 
  EFC37740.1  74 QEMGLLSSMGFNFAQIHYQILAIIIAIFLN 103
                 8************************99984 PP

  == domain 3  score: -5.6 bits;  conditional E-value: 5
        FtsX  29 tlvalviGlgl........gllaaqllsdvllssvfsselkisidlitvliiivlllllall 82 
                 +++++  G++         ++l+  + ++++l s++     +s ++i+ + +++l+ + +ll
  EFC37740.1 248 SVFGFYCGYIYaktscilaAILLHAYCNQMGLPSFN-----MSKPIIATFYVFGLISFWILL 304
                 222222222224442222244444445555555544.....333333333333332222222 PP

>> DUF1761  Protein of unknown function (DUF1761)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.2     0.031   1.1e+02      30      73 ..      30      76 ..       8     109 .. 0.54
   2 ?   12.6   3.2   3.5e-05      0.12      45     121 ..     175     251 ..     138     255 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.031
     DUF1761 30 rgmteekakeaenk..alamglslvlslliayvlaallaalga.rtf 73
                  + + +++ ++     + ++ls ++s++ + +++++++  ++ + +
  EFC37740.1 30 GSLAKSRNEPSQVRrrSISVLLSSLVSIIYSCLVYLFFGNHEShQEM 76
                44444444443333446777777888888888888887766654333 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 3.5e-05
     DUF1761  45 lamglslvlslliayvlaallaalgartfkagallglllglgfiapaiisnalfekkslklvlIdagywlvtllvmg 121
                 +++++ l  +++   +l +ll  +g  ++ +++l+++ll+       ii+++++ + s++  lI+++ +++ + v g
  EFC37740.1 175 AIVMGPLTEEIVFRTCLHYLLYYYGGISLLSSLLIACLLFGVCHCHHIIEHVVHGQMSITSALINVIVQFTYTSVFG 251
                 4555666677788889999**************************************************99988877 PP

>> DUF418  Protein of unknown function (DUF418)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.1   0.00029         1      11      91 ..       3      83 ..       1      84 [. 0.90
   2 ?   -0.4   0.2      0.26   9.4e+02     104     133 ..     186     214 ..     181     220 .. 0.72
   3 ?    0.1   3.5      0.19   6.9e+02      20      68 ..     207     259 ..     191     278 .. 0.47
   4 ?   -1.7   0.1      0.67   2.4e+03      57      75 ..     283     301 ..     261     307 .. 0.63

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00029
      DUF418 11 eehkrllrrllligllvglplnlllavlaeaaeesallelllsvlrylaglllalgyvalillllakekrrrllralaavG 91
                e+++++l ++ +i l +  +++l+++    a +++ + +     ++ l + l++++y +l++l++ + ++++ + +l+++G
  EFC37740.1  3 ENSREILAVIHAIVLSALYVGSLYMWDGSLAKSRNEPSQVRRRSISVLLSSLVSIIYSCLVYLFFGNHESHQEMGLLSSMG 83
                678888999999999999999999998899999999******************************999988799998887 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.26
      DUF418 104 ictllfygyglglfgslgraallllallif 133
                 ++ +   +y l  +g ++ + +ll+a+l+f
  EFC37740.1 186 VFRTC-LHYLLYYYGGISLLSSLLIACLLF 214
                 55553.378888888888888888888876 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.19
      DUF418  20 llligllvglplnllla....vlaeaaeesallelllsvlrylaglllalgyv 68 
                 ll+++ll g+     ++       ++++++ +++ ++++ ++++g++ +++y+
  EFC37740.1 207 LLIACLLFGVCHCHHIIehvvHGQMSITSALINVIVQFTYTSVFGFYCGYIYA 259
                 33333333333322222222222233333444444444444444444444444 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.67
      DUF418  57 ylaglllalgyvalillll 75 
                 +++++++a +yv +++ ++
  EFC37740.1 283 NMSKPIIATFYVFGLISFW 301
                 4556666666666666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       939  (0.0523733); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1808.27
//
Query:       EFC37741.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       575  (0.0320709); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.48
# Mc/sec: 960.70
//
Query:       EFC37742.1  [L=448]
Description: TPR repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.4e-10   38.4   0.3    4.8e-07   29.3   0.1    2.9  2  TPR_1     Tetratricopeptide repeat
    1.4e-08   34.2   0.1    0.00014   21.7   0.0    2.9  2  TPR_2     Tetratricopeptide repeat
    5.8e-06   26.1   0.1     0.0016   18.5   0.0    2.8  2  TPR_8     Tetratricopeptide repeat
      0.006   17.0   0.0      0.012   16.1   0.0    1.5  1  BTAD      Bacterial transcriptional activator domain
     0.0088   16.5   0.1      0.018   15.5   0.1    1.6  1  TPR_19    Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.01   15.5   0.3        4.7    7.0   0.0    2.8  2  TPR_11    TPR repeat
       0.11   12.6   0.2       0.27   11.4   0.2    1.6  1  PIF6      Per os infectivity factor 6


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.0    0.0038       9.7      11      30 ..      14      33 ..       9      35 .. 0.85
   2 !   29.3   0.1   1.9e-10   4.8e-07       2      32 ..      51      81 ..      50      83 .. 0.95

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0038
                HHHTT-HHHHHHHHHHHHHH CS
       TPR_1 11 yfklgkydeAleyyekALel 30
                + + +k+ +A e y++A++l
  EFC37742.1 14 FVREKKFAQAKEVYSEAIRL 33
                66789*************98 PP

  == domain 2  score: 29.3 bits;  conditional E-value: 1.9e-10
                HHHHHHHHHHHHTT-HHHHHHHHHHHHHHST CS
       TPR_1  2 kalynlGnayfklgkydeAleyyekALelnP 32
                ++++n+++a+++l++y++A+ +++++L l+P
  EFC37742.1 51 RVFNNRAQACLSLKEYEQAIFDCNQVLNLDP 81
                789***************************9 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00049       1.2       7      30 ..      10      33 ..       8      35 .. 0.91
   2 !   21.7   0.0   5.6e-08   0.00014       2      34 .]      51      83 ..      50      83 .. 0.93

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00049
       TPR_2  7 lGlayyklgdyeeAleafekAlel 30
                +G+   + +++++A+e + +A++l
  EFC37742.1 10 QGNNFVREKKFAQAKEVYSEAIRL 33
                68889999**************98 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 5.6e-08
       TPR_2  2 ealynlGlayyklgdyeeAleafekAleldPnn 34
                ++ +n+++a++ l++ye+A+ +++++l ldP n
  EFC37742.1 51 RVFNNRAQACLSLKEYEQAIFDCNQVLNLDPLN 83
                5789***************************65 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.019        48      13      30 ..      16      33 ..      10      33 .. 0.86
   2 !   18.5   0.0   6.3e-07    0.0016       2      32 ..      51      81 ..      50      81 .. 0.96

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.019
                HTT-HHHHHHHHHHHHHH CS
       TPR_8 13 klgdyeeAkeyyekalel 30
                  +++ +Ake+y +a++l
  EFC37742.1 16 REKKFAQAKEVYSEAIRL 33
                67899**********986 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 6.3e-07
                CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8  2 eayynlgsiylklgdyeeAkeyyekaleldp 32
                ++ +n ++++l+l++ye+A+  ++++l ldp
  EFC37742.1 51 RVFNNRAQACLSLKEYEQAIFDCNQVLNLDP 81
                7899**************************9 PP

>> BTAD  Bacterial transcriptional activator domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   4.7e-06     0.012      51     105 ..      39      93 ..       7     102 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 4.7e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT-HHHHHHHHHH CS
        BTAD  51 eaererleelrlealealaeaelrlGraeealaelealvaehPlrErlhrqlmrA 105
                  +  e+++++ ++++  +a+a l+l ++e+a+ + ++ ++++Pl+E++   l++ 
  EFC37742.1  39 DQSSEEVKQQYVRVFNNRAQACLSLKEYEQAIFDCNQVLNLDPLNEKAIIRLIQS 93 
                 56778999***************************************99888875 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   7.1e-06     0.018       5      58 ..      18      83 ..      14      94 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 7.1e-06
      TPR_19  5 gdyaeAlalleqal.......qe.....dpknaearllLAeallalgqldeAealLdalpeedpdd 58
                +++a+A + +++a+       ++     + ++ ++  + A+a+l+l+++++A+  ++++++ dp +
  EFC37742.1 18 KKFAQAKEVYSEAIrllsmvgDQsseevKQQYVRVFNNRAQACLSLKEYEQAIFDCNQVLNLDPLN 83
                5666666666665533333334433333666999999****************9999999999875 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0    0.0045        12       1      23 [.      11      33 ..      11      35 .. 0.94
   2 ?    7.0   0.0    0.0018       4.7       2      27 ..      58      83 ..      57      87 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0045
      TPR_11  1 GdayyeqGkyeeAieaYkkAlkl 23
                G+ ++   k+ +A e+Y++A++l
  EFC37742.1 11 GNNFVREKKFAQAKEVYSEAIRL 33
                88899999*************98 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0018
      TPR_11  2 dayyeqGkyeeAieaYkkAlkldPdn 27
                +a+ ++ +ye+Ai + ++ l+ldP n
  EFC37742.1 58 QACLSLKEYEQAIFDCNQVLNLDPLN 83
                6888999*****************76 PP

>> PIF6  Per os infectivity factor 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2   0.00011      0.27       1      57 [.     308     363 ..     308     376 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00011
        PIF6   1 vnwkylntdlievspedRelaWkellielakatpldrtfRtgltvadlenFDykqPl 57 
                 vnw  + +  ++v + d+   W +l++e   +t  ++     +  a++++FDy + l
  EFC37742.1 308 VNWYAIHKGDVVVRDFDKH-IWSRLILEEVDNTANQEELFIDFMAAQFNHFDYFTSL 363
                 6888888888888887765.6******9988888777788999**********8766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (448 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       569  (0.0317363); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2751.44
//
Query:       EFC37743.1  [L=322]
Description: hypothetical protein NAEGRDRAFT_82816 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      4e-24   84.3  15.4    5.5e-11   42.3   1.4    4.2  3  SapB_1           Saposin-like type B, region 1
    1.4e-18   66.6  19.7      1e-08   35.1   0.5    4.7  5  SapB_2           Saposin-like type B, region 2
     0.0042   16.8   0.0     0.0089   15.7   0.0    1.5  1  DUF3507          Domain of unknown function (DUF3507)
  ------ inclusion threshold ------
      0.016   15.8   0.1        1.6    9.3   0.0    2.6  3  Phospholip_A2_3  Prokaryotic phospholipase A2
      0.018   15.1   0.2        6.1    7.0   0.0    2.7  2  YmgD             YmgD protein


Domain annotation for each model (and alignments):
>> SapB_1  Saposin-like type B, region 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.5   7.9e-09   2.8e-05       2      38 .]      28      62 ..      27      62 .. 0.96
   2 !   42.3   1.4   1.5e-14   5.5e-11       2      38 .]     130     166 ..     129     166 .. 0.97
   3 !   25.6   1.1   2.5e-09     9e-06       2      38 .]     228     264 ..     227     264 .. 0.98

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 7.9e-09
                HHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHHHS- CS
      SapB_1  2 eCdlCefvVkeveklLkdNkTeeeIieaLekvCskLP 38
                +C++Ce++V+ ve l  +   e  I++aL  vCs+L+
  EFC37743.1 28 FCSVCEYAVQTVEALALKE--EPAIEKALLGVCSQLG 62
                7****************88..**************96 PP

  == domain 2  score: 42.3 bits;  conditional E-value: 1.5e-14
                 HHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHHHS- CS
      SapB_1   2 eCdlCefvVkeveklLkdNkTeeeIieaLekvCskLP 38 
                 eC++C+++V+++e+++++N +++eI + L+++Cs +P
  EFC37743.1 130 ECEICKYAVGQIENFINSNHSQQEIQKKLNQLCSNIP 166
                 8*********************************998 PP

  == domain 3  score: 25.6 bits;  conditional E-value: 2.5e-09
                 HHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHHHS- CS
      SapB_1   2 eCdlCefvVkeveklLkdNkTeeeIieaLekvCskLP 38 
                  C +C +++  v+ ++++++  + +++ L+kvC+kLP
  EFC37743.1 228 ICPACIMAMELVQREINQQSIDKFVEDKLDKVCAKLP 264
                 6***********************************9 PP

>> SapB_2  Saposin-like type B, region 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       0.8   2.9e+03      27      32 ..      57      62 ..      56      62 .. 0.89
   2 !   23.6   0.5   1.1e-08     4e-05       2      34 .]      69     102 ..      68     102 .. 0.94
   3 !   20.1   0.5   1.4e-07    0.0005      11      34 .]     180     203 ..     171     203 .. 0.91
   4 ?   -3.1   0.1       2.5     9e+03      25      31 ..     257     263 ..     257     263 .. 0.81
   5 !   35.1   0.5   2.8e-12     1e-08       3      34 .]     271     302 ..     269     302 .. 0.98

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.8
                HHHHTT CS
      SapB_2 27 vCtalg 32
                vC++lg
  EFC37743.1 57 VCSQLG 62
                9***98 PP

  == domain 2  score: 23.6 bits;  conditional E-value: 1.1e-08
                 HHHHHHHHHHHHHHCCHCTT--HHHHHHH.TTSS CS
      SapB_2   2 eCkslVdqYgpliiqlLlseldPkevCta.lglC 34 
                  C+++V  Yg+++++ L+ +++P  vCt+ l lC
  EFC37743.1  69 ICNTVVLVYGHELLNALITYETPVRVCTDqLPLC 102
                 7***************************988887 PP

  == domain 3  score: 20.1 bits;  conditional E-value: 1.4e-07
                 HHHHHCCHCTT--HHHHHHHTTSS CS
      SapB_2  11 gpliiqlLlseldPkevCtalglC 34 
                 +p ii+ L+ + +P ++C+ l+lC
  EFC37743.1 180 VPYIIKKLEDHNSPSQICSGLHLC 203
                 699********88*********** PP

  == domain 4  score: -3.1 bits;  conditional E-value: 2.5
                 HHHHHHT CS
      SapB_2  25 kevCtal 31 
                 ++vC++l
  EFC37743.1 257 DKVCAKL 263
                 689*987 PP

  == domain 5  score: 35.1 bits;  conditional E-value: 2.8e-12
                 HHHHHHHHHHHHHCCHCTT--HHHHHHHTTSS CS
      SapB_2   3 CkslVdqYgpliiqlLlseldPkevCtalglC 34 
                 C++lVd+Y+p+++q Ll  ++P+++C+ +++C
  EFC37743.1 271 CENLVDTYTPVLVQKLLLAVTPTKICKFVHAC 302
                 ******************************** PP

>> DUF3507  Domain of unknown function (DUF3507)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   2.5e-06    0.0089      59     107 ..     239     287 ..     231     300 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2.5e-06
     DUF3507  59 sseklsalvldklGvsllesvdlsskSrfypaveNLspkyqksnvrksl 107
                  +++++ +++dk+    l++v  +  S f pa+eNL   y    v+k l
  EFC37743.1 239 VQREINQQSIDKFVEDKLDKVCAKLPSTFGPACENLVDTYTPVLVQKLL 287
                 5678999*********************************999999965 PP

>> Phospholip_A2_3  Prokaryotic phospholipase A2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.1   1.1e+04      80     103 ..      53      77 ..      47      80 .. 0.70
   2 ?    3.5   0.0     0.031   1.1e+02      71     103 ..     148     180 ..     137     187 .. 0.82
   3 ?    9.3   0.0   0.00046       1.6      67     104 ..     242     279 ..     235     285 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.1
  Phospholip_A2_3  80 dlkkqCkkve.klkkkaCkaladvy 103
                       l  +C++   +   k C+++  vy
       EFC37743.1  53 ALLGVCSQLGdNQFGKICNTVVLVY 77 
                      5666788755466678888888777 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.031
  Phospholip_A2_3  71 kridknfkkdlkkqCkkveklkkkaCkaladvy 103
                      ++ +++ +k l++ C++  ++ +++C ++a++ 
       EFC37743.1 148 NHSQQEIQKKLNQLCSNIPSVFTQTCLSIARMV 180
                      556789999********9999******999875 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00046
  Phospholip_A2_3  67 eanrkridknfkkdlkkqCkkveklkkkaCkaladvyy 104
                      e n++ idk  ++ l k+C+k  ++   aC++l d+y 
       EFC37743.1 242 EINQQSIDKFVEDKLDKVCAKLPSTFGPACENLVDTYT 279
                      457899***9999********99*************96 PP

>> YmgD  YmgD protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0    0.0017       6.1      49      77 ..     149     177 ..     139     180 .. 0.82
   2 ?    5.2   0.0    0.0059        21      47      67 ..     245     265 ..     208     268 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0017
                 HHHHHHHHHHHHHHHH-TT-BHHHHHHHH CS
        YmgD  49 eldkdvveklnqvcakdPqmllitaidda 77 
                 + ++++ +klnq c++ P ++  t++ +a
  EFC37743.1 149 HSQQEIQKKLNQLCSNIPSVFTQTCLSIA 177
                 55678899**********99888877665 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0059
                 -HHHHHHHHHHHHHHHHH-TT CS
        YmgD  47 speldkdvveklnqvcakdPq 67 
                 +  +dk v +kl++vcak P 
  EFC37743.1 245 QQSIDKFVEDKLDKVCAKLPS 265
                 45799************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1148  (0.0640303); expected 358.6 (0.02)
Passed bias filter:                      758  (0.0422779); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2026.88
//
Query:       EFC37744.1  [L=809]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-19   68.9  36.2    1.6e-11   44.4  15.9    3.7  5  Na_Ca_ex  Sodium/calcium exchanger protein
    8.1e-16   58.5  16.7    8.1e-16   58.5  16.7    5.0  6  YccF      Inner membrane component domain


Domain annotation for each model (and alignments):
>> Na_Ca_ex  Sodium/calcium exchanger protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.1      0.11     1e+03     108     121 ..     200     213 ..     142     241 .. 0.48
   2 ?   -3.6   0.4         1   9.4e+03     105     120 ..     302     316 ..     293     328 .. 0.52
   3 ?   -4.5   0.6         2   1.8e+04      76      89 ..     379     392 ..     371     396 .. 0.71
   4 !   39.3  12.3   6.7e-14     6e-10       3     138 ..     406     541 ..     404     546 .. 0.81
   5 !   44.4  15.9   1.8e-15   1.6e-11       3     148 ..     658     803 ..     656     806 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.11
                 HHHHHHHHHHHHTC CS
    Na_Ca_ex 108 lvallllllvllll 121
                 + +l+  +l+l ++
  EFC37744.1 200 YSLLWGWWLFLSYI 213
                 33333333222222 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1
                 HHHHHHHHHHHHHHHT CS
    Na_Ca_ex 105 llllvallllllvlll 120
                 +l++v +++++ +++l
  EFC37744.1 302 ILFIVHCVCCV-LSWL 316
                 34444443322.2222 PP

  == domain 3  score: -4.5 bits;  conditional E-value: 2
                 HHHHHTHHHHHHHH CS
    Na_Ca_ex  76 ifnlllviGliali 89 
                 +fn+l  ++l++++
  EFC37744.1 379 LFNMLPFVPLSIVL 392
                 68999999988876 PP

  == domain 4  score: 39.3 bits;  conditional E-value: 6.7e-14
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHHTHHHHHHHHHHBTTSSCECCH CS
    Na_Ca_ex   3 fvlfilslllisvladflvssaeeiakslgisgsvlGltllAlgnslpElissiiaaltgevdlaignvlGsnifnlllviGlialigslkvdseslkl 101
                 +++f+ ++l++++l+ ++++++++i+     s  v+G +l+A ++s+ E+i+ ++ + +g   +++ +v+Gs + ++ll+ Gl++++g+  +++ ++ +
  EFC37744.1 406 VGIFVTCILAVIPLSYYISKAVSSIS---AQSNYVVGAFLNASFGSVVEIILYFATLYKGMSAIVMQAVTGSFLGDTLLIPGLSMIFGG-FKHRVQY-F 499
                 789***********************...89999*******************************************************.5555664.4 PP

                 HHHHHHHHHHHHHHHHHHTCHHHHH.....HTEEHHHHHHHH CS
    Na_Ca_ex 102 dlgllllvallllllvlllllplfv.....pgrltvleglvl 138
                 +  +  + +llll++++ +++p  +       +lt l ++ l
  EFC37744.1 500 NKHAAGTSSLLLLVATVGCFVPSLFytiygNYELTCLSCVDL 541
                 443445556666666665565665556666667777666655 PP

  == domain 5  score: 44.4 bits;  conditional E-value: 1.8e-15
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHHHHHHHHHHHHHHTTTHHHHH..HHHHHHHHHHHHTHHHHHHHHHH....BTTS CS
    Na_Ca_ex   3 fvlfilslllisvladflvssaeeiakslgisgsvlGltllAlgnslpElissiiaaltgevdlai..gnvlGsnifnlllviGlialigs....lkvd 95 
                 ++++++++++ ++ a+ +++s+e   + lgi+ +++Glt++Al+ ++ E++s+i +al+++v+l++  gnv G  i+  l+ i+  +++++    + + 
  EFC37744.1 658 VLILLIATIAFAFVAEAMTKSLEPAFEPLGIPLEFAGLTIFALVPNISEIVSAIKFALQNNVTLSLeiGNVAG--IQTALIQIPALVIFSTiifqEDI- 753
                 67899999999999*********99999*********************************666662267766..8899999*******996432222. PP

                 SCE..CCHHHHHHHHHHHHHHHHHHHTCHHHHHHTEEHHHHHHHHHHHHHHHHHH CS
    Na_Ca_ex  96 ses..lkldlgllllvallllllvlllllplfvpgrltvleglvllllYalylvl 148
                   +  + l+++ l lva+++ +++l ++++    g+ +++ g+ ll++Y+++++ 
  EFC37744.1 754 --TkvFSLTFPRLDLVAIFFAVIILNYVTID---GKSNYFHGFSLLVVYLIIVIS 803
                 ..23368888888888888888888877555...****************99875 PP

>> YccF  Inner membrane component domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.5  16.7     9e-20   8.1e-16       1      51 []     195     245 ..     195     245 .. 0.99
   2 !    8.2   7.1   0.00044         4       4      40 ..     293     329 ..     290     335 .. 0.90
   3 ?   -4.4   0.4         2   1.8e+04      14      22 ..     408     416 ..     405     423 .. 0.48
   4 ?   -3.2   0.6       1.6   1.4e+04      16      27 ..     509     520 ..     507     543 .. 0.49
   5 ?   -1.3   0.2      0.41   3.7e+03      13      28 ..     655     670 ..     654     687 .. 0.63
   6 ?   -3.1   2.2       1.6   1.4e+04      10      27 ..     789     806 ..     787     809 .] 0.76

  Alignments for each domain:
  == domain 1  score: 58.5 bits;  conditional E-value: 9e-20
        YccF   1 lgNilWlllfGwwlaliyllaglllfitiigipygrvlfklakyllwPFGk 51 
                 +gNi+++ll Gwwl+l y++++ll+++ti++ipyg  ++ +a y +wPFGk
  EFC37744.1 195 FGNIVYSLLWGWWLFLSYIFVALLCYLTIFCIPYGNKCLSMAFYYFWPFGK 245
                 69************************************************8 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00044
        YccF   4 ilWlllfGwwlaliyllaglllfitiigipygrvlfk 40 
                 ++W ++   +l+++++++ +l  +t++gip  +v f+
  EFC37744.1 293 VIWCIFPAPILFIVHCVCCVLSWLTVFGIPTTKVQFH 329
                 79*****************************998886 PP

  == domain 3  score: -4.4 bits;  conditional E-value: 2
        YccF  14 laliyllag 22 
                 +++ ++la 
  EFC37744.1 408 IFVTCILAV 416
                 333444433 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 1.6
        YccF  16 liyllaglllfi 27 
                 l+ l+a + +f+
  EFC37744.1 509 LLLLVATVGCFV 520
                 455555555653 PP

  == domain 5  score: -1.3 bits;  conditional E-value: 0.41
        YccF  13 wlaliyllaglllfit 28 
                 w++++ ll++ + f +
  EFC37744.1 655 WVCVLILLIATIAFAF 670
                 4444444444444433 PP

  == domain 6  score: -3.1 bits;  conditional E-value: 1.6
        YccF  10 fGwwlaliyllaglllfi 27 
                  G+ l ++yl++ + +f+
  EFC37744.1 789 HGFSLLVVYLIIVISFFF 806
                 588888999998888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (809 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1077  (0.0600703); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.81u 0.32s 00:00:01.13 Elapsed: 00:00:00.52
# Mc/sec: 4718.02
//
Query:       EFC37745.1  [L=538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      1e-64  218.7   0.0    1.8e-64  218.0   0.0    1.4  1  GMC_oxred_N    GMC oxidoreductase
    4.6e-05   24.0   0.0    9.2e-05   23.0   0.0    1.5  1  GMC_oxred_C    GMC oxidoreductase
    0.00024   21.3   0.1     0.0007   19.8   0.1    1.8  1  NAD_binding_8  NAD(P)-binding Rossmann-like domain
     0.0046   16.2   0.0     0.0087   15.3   0.0    1.4  1  Pyr_redox_2    Pyridine nucleotide-disulphide oxidoreductase
     0.0057   15.8   0.0     0.0085   15.2   0.0    1.2  1  Lycopene_cycl  Lycopene cyclase protein
  ------ inclusion threshold ------
      0.034   13.4   0.0       0.11   11.7   0.0    1.7  2  Thi4           Thi4 family
      0.046   12.8   0.0       0.93    8.5   0.0    2.1  2  FAD_binding_2  FAD binding domain
      0.065   12.9   0.0       0.17   11.5   0.0    1.7  1  ApbA           Ketopantoate reductase PanE/ApbA
       0.16   11.5   0.0        0.7    9.4   0.0    1.9  2  DAO            FAD dependent oxidoreductase


Domain annotation for each model (and alignments):
>> GMC_oxred_N  GMC oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  218.0   0.0   8.9e-68   1.8e-64       1     295 [.      51     371 ..      51     372 .. 0.89

  Alignments for each domain:
  == domain 1  score: 218.0 bits;  conditional E-value: 8.9e-68
  GMC_oxred_N   1 vdelveggGsagsvvAaRLsedpstsvlvleaggreknrlimvlalalklidkklntayetepek.....alngrrlilpaGktlGGgsvvNwsayiR 93 
                  +d++++g+Gsagsv+A+RLs++ ++svl+leag +++ +l ++  l l ++++  +++y+t  e+     +   + +++p+Gk+lGG+s++N+++y+R
   EFC37745.1  51 FDFIIVGSGSAGSVLANRLSQNVNHSVLLLEAGKSDNTPLAKFTPLYLFMLKSVHDWQYYTIGEEseinpKHLLKKMFWPRGKILGGSSSMNAMIYMR 148
                  69**************************************7777777777777788888776554100004445789********************* PP

  GMC_oxred_N  94 tpaadldeWee.eag..legwssdevlpafkkvetaqale....sdlhgvdgrlgvtekgkeesplnkallkaaeelGlp............vprdln 172
                  ++ +d+d W+e e+g   ++w+ + vl++fkk+e +q +      ++hg +g+  v+e+g++ s +  ++ + ++ l +p             +++++
   EFC37745.1 149 GSPQDYDTWNEcEFGgkSKIWNFEHVLKYFKKSEAQQGPAeifsDEYHGRNGEWIVKEQGETFSIIEPVVKAMSQVLSIPivrdlnnpkithSKDNSQ 246
                  *********98445422789**************99998899*99***********999999998888888888889999878888888876677777 PP

  GMC_oxred_N 173 gk..hqcGvcllgvtcrtgarqstarawLrpal.erpnleiltgakaekiilegrkkravGVeasdkkgtvkrlvvaakevvvaaGalnsPqlLqrSG 267
                  ++  ++ +v+ ++     g+r+sta+a+L +++ +rpnl + t+a a+ i++e  +++avGV++ d  +++   ++ +kev++++Ga+nsPqlL++SG
   EFC37745.1 247 SDfvEYGAVGTTQIHSLHGRRFSTADAFLNDTVlKRPNLFVRTEALATNILFE--GNKAVGVRYFDRRKKAYVEKRVRKEVILSGGAINSPQLLMLSG 342
                  77888888999998999***************99*******************..***************89999999******************** PP

  GMC_oxred_N 268 lGkaehLkevgvdvvvdlp.vGknLqdHp 295
                  +G+ ++L ++++ ++vd   vGk L+dH+
   EFC37745.1 343 IGDSKELSKHNITTIVDNKnVGKHLHDHL 371
                  ****************************8 PP

>> GMC_oxred_C  GMC oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   4.6e-08   9.2e-05       1      41 [.     485     525 ..     485     527 .. 0.97

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 4.6e-08
                  ----EEEEESTT-TCCEEEEE--TT-SHHHHHHHHHHHHHH CS
  GMC_oxred_C   1 PesrGrvtlsssdptgaplidpnylsdprdlaalvealkaa 41 
                  P+srG ++l+s++p +ap+id n+  +++d+++++ea++ a
   EFC37745.1 485 PKSRGGLKLKSNNPFVAPIIDSNFVGHKHDKETMAEAIRSA 525
                  89************************************976 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.1   3.5e-07    0.0007       1      28 [.      55      83 ..      55      85 .. 0.95

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 3.5e-07
                   EE--SHHHHHHHHHHHCC.TEEEEEE-SS CS
  NAD_binding_8  1 IvGaGlsGlvaAylLaka.gfdvlllekr 28
                   IvG+G +G+v+A +L+++ +++vllle++
     EFC37745.1 55 IVGSGSAGSVLANRLSQNvNHSVLLLEAG 83
                   9****************99********97 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   4.4e-06    0.0087       2      51 ..      52     105 ..      51     140 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 4.4e-06
                  SEEEE--SHHHHHHHHHHHHH.TS-EEEEE...TTHCHHHCSHHHHCHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxx.xxxxxxxx...xxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaqa.gakvtlve...legtclnggcllskallgvae 51 
                  d +++G+G AG  +a +l+q+ ++ v+l+e   +++t l    +l+  +l++ +
   EFC37745.1  52 DFIIVGSGSAGSVLANRLSQNvNHSVLLLEagkSDNTPLAKFTPLYLFMLKSVH 105
                  789*****************77*******9775333333333334555555555 PP

>> Lycopene_cycl  Lycopene cyclase protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   4.3e-06    0.0085       1      35 [.      52      85 ..      52      94 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 4.3e-06
  Lycopene_cycl  1 DvvviGaGpAglslAarlteakpglkvvlieasps 35
                   D +++G+G Ag  lA+rl +++ + +v+l+ea++s
     EFC37745.1 52 DFIIVGSGSAGSVLANRL-SQNVNHSVLLLEAGKS 85
                   89****************.9999*********986 PP

>> Thi4  Thi4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   5.5e-05      0.11       9      49 ..      42      82 ..      37      86 .. 0.89
   2 ?   -2.1   0.0      0.89   1.8e+03      79     120 ..     303     344 ..     288     379 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.5e-05
                HHHHHHHTEEEEEEE--SHHHHHHHHHHHHCTTS-EEEEES CS
        Thi4  9 fedllkyaesDvvivGaGssGLtaayylakkpdlkvailer 49
                f++ ++  e D +ivG+Gs+G   a  l+++ +  v++le+
  EFC37745.1 42 FQNHQDPKEFDFIIVGSGSAGSVLANRLSQNVNHSVLLLEA 82
                6777888899***********************9***9997 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.89
                 HTT---EEESSEEEESEHHHHHHHHHHHHHTSTTEEEEESEE CS
        Thi4  79 elgikyedegdyvvvkdaalftstllskvlqlanvkllnava 120
                  +g++y d+++  +v++ +     l   +++ +++ +l ++ 
  EFC37745.1 303 AVGVRYFDRRKKAYVEKRVRKEVILSGGAINSPQLLMLSGIG 344
                 589999999999999998888888888888877777766665 PP

>> FAD_binding_2  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0   0.00046      0.93       1      33 [.      52      85 ..      52      92 .. 0.88
   2 ?    2.1   0.0      0.04        80     151     204 ..     279     334 ..     264     364 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00046
                   SEEEE--SHHHHHHHHHHHHTTT.-EEEEESSSG CS
  FAD_binding_2  1 DviViGsGlAGLaAAleaaeaGl.kvavvekeqe 33
                   D i++GsG AG + A +++++   +v+++e +++
     EFC37745.1 52 DFIIVGSGSAGSVLANRLSQNVNhSVLLLEAGKS 85
                   88******************7766*****99876 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.04
                    HHTCT.EEEEESEEEEEEEECTTEEEEEEEEETTTTCEEEEEES.EEEE-----GG CS
  FAD_binding_2 151 arkag.vdfqerteadeLivedgrvtGavvenpesgrevrirak.avvlatgGfgr 204
                    ++k++ + +++++ a++++ e+++++G+   +++++  v+ r +  v+l  g+++ 
     EFC37745.1 279 VLKRPnLFVRTEALATNILFEGNKAVGVRYFDRRKKAYVEKRVRkEVILSGGAINS 334
                    5555567789999******************9988888887877799999998886 PP

>> ApbA  Ketopantoate reductase PanE/ApbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   8.6e-05      0.17       2      27 ..      54      80 ..      53      91 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 8.6e-05
                EEES-SHHHHHHHHHHHH.HTHCEEEE CS
        ApbA  2 ailGaGaiGsllaakLak.agadvtli 27
                 i+G+G+ Gs+la +L++  ++ v l+
  EFC37745.1 54 IIVGSGSAGSVLANRLSQnVNHSVLLL 80
                69****************555556665 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   0.00035       0.7       1      29 [.      52      83 ..      52      88 .. 0.88
   2 ?   -1.0   0.0      0.51     1e+03     163     207 ..     297     337 ..     244     388 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00035
                EEEEECTSHHHHHHHHHHHHT.T..EEEEESS CS
         DAO  1 dvviiGGGiiGlstAyeLarr.g..Vtllekg 29
                d +i+G+G +G+  A  L++  +  V+lle+g
  EFC37745.1 52 DFIIVGSGSAGSVLANRLSQNvNhsVLLLEAG 83
                789***************9986368*****98 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.51
                 EEESECEEEEEEEETCEEEEE....EECTEEEEEEEE.EEE--GGGHH.HH CS
         DAO 163 ilegtevtgleeedgkvwgve....rttpgendaada.vVnaaGawsd.ll 207
                 ++eg +++g+          +    r+++  ++++++ v+++ Ga  + +l
  EFC37745.1 297 LFEGNKAVGV----------RyfdrRKKAYVEKRVRKeVILSGGAINSpQL 337
                 3444455555..........4443211112122345569999998754433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       694  (0.0387082); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 3264.79
//
Query:       EFC37746.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-06   28.1  69.9     0.0018   18.6   8.5   10.2 13  LRR_4     Leucine Rich repeats (2 copies)
     0.0039   17.1  39.4      0.012   15.6   0.0    9.9 11  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
        3.6    7.1  17.7        2.9    7.4   7.1    3.5  4  LRR_9     Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.44   2.6e+03      24      32 ..       6      14 ..       6      28 .. 0.74
   2 ?    0.7   0.1      0.13   7.8e+02      21      32 ..      55      66 ..      34      73 .. 0.61
   3 !    5.2   3.7    0.0051        31      21      38 ..      82     100 ..      58     108 .. 0.72
   4 !    8.1   8.1   0.00064       3.8       2      42 ..      86     125 ..      82     129 .. 0.85
   5 !   18.6   8.5     3e-07    0.0018       1      36 [.     108     143 ..     108     149 .. 0.87
   6 !   15.6   7.8   2.7e-06     0.016       1      31 [.     130     161 ..     130     166 .. 0.88
   7 !    4.6   4.8    0.0077        46       2      33 ..     154     189 ..     153     206 .. 0.61
   8 ?    3.0   0.2     0.025   1.5e+02      17      30 ..     199     212 ..     192     220 .. 0.76
   9 !    6.0   2.3    0.0028        16       1      41 [.     205     252 ..     205     259 .. 0.61
  10 !    8.2   0.8   0.00057       3.4       2      37 ..     287     326 ..     286     329 .. 0.71
  11 !   10.0   2.9   0.00015      0.92       2      37 ..     314     353 ..     313     362 .. 0.80
  12 !   13.4   2.5   1.3e-05      0.08       1      33 [.     340     377 ..     340     388 .. 0.82
  13 !    7.0   0.2    0.0014       8.5       1      28 [.     367     398 ..     367     399 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.44
                T--EEE-.- CS
       LRR_4 24 nLkeLdLsg 32
                nL+ L+Lsg
  EFC37746.1  6 NLTGLNLSG 14
                455555555 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.13
                H.-TT--EEE-.- CS
       LRR_4 21 k.lpnLkeLdLsg 32
                  l nL++L + g
  EFC37746.1 55 ElLENLESLRV-G 66
                22788888877.5 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0051
                 H-TT.--EEE-.-S----- CS
       LRR_4  21 klpn.LkeLdLsgNnlitd 38 
                 +l n L++LdLs+N  +++
  EFC37746.1  82 NLNNqLTSLDLSNNYGLDT 100
                 4555599999988866655 PP

  == domain 4  score: 8.1 bits;  conditional E-value: 0.00064
                 S--EEE--SS.---E-S-HHH-TT--EEE-.-S-----GGGG CS
       LRR_4   2 nLevLdLsnN.qltdiplleklpnLkeLdLsgNnlitdldeL 42 
                 +L++LdLsnN  l +i   +  +nLk+L ++++  i +ld L
  EFC37746.1  86 QLTSLDLSNNyGLDTIFTSNIVKNLKVLKINDC-GIVSLD-L 125
                 699*******99**98887779********888.776774.5 PP

  == domain 5  score: 18.6 bits;  conditional E-value: 3e-07
                 SS--EEE--SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnli 36 
                 +nL+vL ++++ + +++l + lpnL+eL+L++N ++
  EFC37746.1 108 KNLKVLKINDCGIVSLDLENPLPNLTELHLNNNIRL 143
                 79****************999*********777555 PP

  == domain 6  score: 15.6 bits;  conditional E-value: 2.7e-06
                 SS--EEE--SS.---E-S-HHH-TT--EEE-. CS
       LRR_4   1 pnLevLdLsnN.qltdiplleklpnLkeLdLs 31 
                 pnL++L+L+nN +l  i+   kl nLk+L+L+
  EFC37746.1 130 PNLTELHLNNNiRLNYINIGDKLSNLKVLNLH 161
                 8********9888888888779*********4 PP

  == domain 7  score: 4.6 bits;  conditional E-value: 0.0077
                 S--EEE--S.......S---E-S-HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsn.......NqltdiplleklpnLkeLdLsgN 33 
                 nL+vL+L+        N l+ +++ + l++L+eLd+ g+
  EFC37746.1 154 NLKVLNLHRageyvlfNDLS-LQNAK-LDQLTELDI-GC 189
                 89999999744444444444.44444.********8.44 PP

  == domain 8  score: 3.0 bits;  conditional E-value: 0.025
                 S-HHH-TT--EEE- CS
       LRR_4  17 plleklpnLkeLdL 30 
                   le+lp+Lk+L L
  EFC37746.1 199 KILENLPKLKKLVL 212
                 45788*****9988 PP

  == domain 9  score: 6.0 bits;  conditional E-value: 0.0028
                 SS--EEE--SS-........--E-S-HHH.-TT--EEE-......-S-----GGG CS
       LRR_4   1 pnLevLdLsnNq........ltdipllek.lpnLkeLdL.....sgNnlitdlde 41 
                 p+L++L L+++         ++     +  ++nL++L+L     s+N    +++ 
  EFC37746.1 205 PKLKKLVLFGTPssdmvcqfIS---ENNElFKNLQSLNLgrtfcSFN----SINF 252
                 6788888888556666633344...333339*******744333555....5554 PP

  == domain 10  score: 8.2 bits;  conditional E-value: 0.00057
                 S--EEE--SS---E-S-..HH...H-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLsgNnlit 37 
                 nL+ L+Ls + lt   l  l     l +L+eL L +N +i+
  EFC37746.1 287 NLTDLSLSYCELTAECLkyLTnspTLSKLQELQLKSN-PIG 326
                 89*******9988522234224545999******666.775 PP

  == domain 11  score: 10.0 bits;  conditional E-value: 0.00015
                 S--EEE--SS---E-S-..HH..H.-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..le..k.lpnLkeLdLsgNnlit 37 
                 +L++L L +N + + +   l+  k ++ L++L+L  N++++
  EFC37746.1 314 KLQELQLKSNPIGSEGCtyLAtsKfITRLTYLNL-CNTQLE 353
                 8************866677558899*********.887884 PP

  == domain 12  score: 13.4 bits;  conditional E-value: 1.3e-05
                 SS--EEE--SS---.E-S-.HH...H-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqlt.dipl.le...klpnLkeLdLsgN 33 
                 ++L++L+L n+ql  d  + l+   +++  +eLd+sgN
  EFC37746.1 340 TRLTYLNLCNTQLEeDNCStLAnstNFTRITELDISGN 377
                 68************554447446768999********9 PP

  == domain 13  score: 7.0 bits;  conditional E-value: 0.0014
                 SS--EEE--SS.---E-S-HH...H-TT--EE CS
       LRR_4   1 pnLevLdLsnN.qltdiplle...klpnLkeL 28 
                 ++ ++Ld+s+N ++ d++ ++   ++pnL+ L
  EFC37746.1 367 TRITELDISGNdNVFDFEIIQksqNFPNLQLL 398
                 57899*****999999999666647****987 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.56   3.3e+03       2      12 ..       4      14 ..       4      14 .. 0.83
   2 ?    4.1   2.9      0.01        61       2      13 ..      84      95 ..      83      95 .. 0.93
   3 ?    0.4   0.1      0.15   8.9e+02       4      15 ..     109     120 ..     108     122 .. 0.90
   4 ?    2.4   0.5     0.035   2.1e+02       3      13 ..     130     140 ..     128     140 .. 0.90
   5 ?   -1.7   0.5      0.72   4.3e+03       3      10 ..     153     160 ..     151     161 .. 0.86
   6 ?    2.5   0.0     0.032   1.9e+02       5      18 ..     182     195 ..     181     200 .. 0.87
   7 ?   -1.5   0.0       0.6   3.6e+03       4      11 ..     234     241 ..     233     242 .. 0.84
   8 !    6.3   0.1     0.002        12       4      18 ..     287     301 ..     287     306 .. 0.88
   9 !   15.6   0.0     2e-06     0.012       3      24 .]     313     334 ..     311     334 .. 0.92
  10 ?   -1.6   0.1      0.65   3.9e+03       4      10 ..     341     347 ..     340     351 .. 0.87
  11 !    5.3   0.0     0.004        24       4      14 ..     368     378 ..     367     380 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.56
       LRR_6  2 nthLteLdLsg 12
                n +Lt L+Lsg
  EFC37746.1  4 NFNLTGLNLSG 14
                67899999996 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.01
       LRR_6  2 nthLteLdLsgN 13
                n+ Lt+LdLs N
  EFC37746.1 84 NNQLTSLDLSNN 95
                899*******99 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.15
       LRR_6   4 hLteLdLsgNdI 15 
                 +L+ L +++++I
  EFC37746.1 109 NLKVLKINDCGI 120
                 79********97 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.035
       LRR_6   3 thLteLdLsgN 13 
                 ++LteL+L+ N
  EFC37746.1 130 PNLTELHLNNN 140
                 79******998 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 0.72
       LRR_6   3 thLteLdL 10 
                 ++L+ L+L
  EFC37746.1 153 SNLKVLNL 160
                 89****98 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.032
       LRR_6   5 LteLdLsgNdIgDe 18 
                 LteLd+ + + +D+
  EFC37746.1 182 LTELDIGCSKCNDS 195
                 9*******999886 PP

  == domain 7  score: -1.5 bits;  conditional E-value: 0.6
       LRR_6   4 hLteLdLs 11 
                 +L++L+L 
  EFC37746.1 234 NLQSLNLG 241
                 799***96 PP

  == domain 8  score: 6.3 bits;  conditional E-value: 0.002
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +Lt L+Ls+++++ e
  EFC37746.1 287 NLTDLSLSYCELTAE 301
                 69**********987 PP

  == domain 9  score: 15.6 bits;  conditional E-value: 2e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L+eL+L++N Ig eG++ La
  EFC37746.1 313 SKLQELQLKSNPIGSEGCTYLA 334
                 79***************99887 PP

  == domain 10  score: -1.6 bits;  conditional E-value: 0.65
       LRR_6   4 hLteLdL 10 
                  Lt+L+L
  EFC37746.1 341 RLTYLNL 347
                 79***98 PP

  == domain 11  score: 5.3 bits;  conditional E-value: 0.004
       LRR_6   4 hLteLdLsgNd 14 
                  +teLd+sgNd
  EFC37746.1 368 RITELDISGND 378
                 689*******8 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   7.1   0.00048       2.9      42     119 ..      85     159 ..      79     186 .. 0.77
   2 ?    1.2   0.6     0.038   2.3e+02      54      95 ..     198     240 ..     168     274 .. 0.63
   3 ?    2.8   0.2     0.013        75      37     126 ..     240     326 ..     232     349 .. 0.60
   4 ?    3.7   0.2    0.0065        39      53     148 ..     302     401 ..     285     414 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00048
       LRR_9  42 dqfdtidlsdn.dirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnne.lqeladldPlaslkklells 119
                 +q+ ++dls+n  +  +     +k lk+l +n+  iv  + +le+ lPnl+el l+nn  l+ ++  d l +lk l    
  EFC37746.1  85 NQLTSLDLSNNyGLDTIFTSNIVKNLKVLKINDCGIV--SLDLENPLPNLTELHLNNNIrLNYINIGDKLSNLKVL---N 159
                 5777888888734666777788999*******99996..569**************99734444443555555544...3 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.038
       LRR_9  54 irkldgfPllkrlktlll.nnnrivriaegleevlPnleelvl 95 
                 i+ l+++P lk+l  +   +++ +++   + +e   nl++l l
  EFC37746.1 198 IKILENLPKLKKLVLFGTpSSDMVCQFISENNELFKNLQSLNL 240
                 6777888877777665441455666666666666666666665 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.013
       LRR_9  37 lGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqe..ladldPlaslkklellsllknpvt 126
                 lG t   f++i++      kl  +  l     + ln +  +++  + e+v  nl+ l l+  el+   l  l    +l+kl+ l l +np+ 
  EFC37746.1 240 LGRTFCSFNSINFLAKSSLKLCRL-IL---DNIKLN-EESCKVLSENEKVFGNLTDLSLSYCELTAecLKYLTNSPTLSKLQELQLKSNPIG 326
                 555555555555554444444333.22...223333.3346666666777777777776655544322445555567777777888788775 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.0065
       LRR_9  53 dirkldgfPllkrlktlllnnnrivriae...gleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyk...lkqlrll 145
                  ++ l + P l +l+ l l++n i   +      ++++ +l+ l l n +l+e +    la+  +++ ++ l+ +  n + +   +i k   +++l+ll
  EFC37746.1 302 CLKYLTNSPTLSKLQELQLKSNPIGSEGCtylATSKFITRLTYLNLCNTQLEEDN-CSTLANSTNFTRITELDIS-GNDNVFDFEIIQKsqnFPNLQLL 398
                 5778999999999999999999997655411134678888888888888887643.3555555555555544432.22333444444432225556666 PP

       LRR_9 146 dfr 148
                 +++
  EFC37746.1 399 EYK 401
                 665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.24s 00:00:00.78 Elapsed: 00:00:00.43
# Mc/sec: 2951.58
//
Query:       EFC37747.1  [L=367]
Description: hypothetical protein NAEGRDRAFT_53573 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.7e-87  291.7   0.0    5.2e-86  288.8   0.0    1.9  1  Actin     Actin
     0.0015   17.4   0.0      0.004   16.0   0.0    1.7  1  MreB_Mbl  MreB/Mbl protein


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  288.8   0.0   5.8e-90   5.2e-86       5     404 ..       4     362 ..       2     365 .. 0.97

  Alignments for each domain:
  == domain 1  score: 288.8 bits;  conditional E-value: 5.8e-90
       Actin   5 savVlDnGssttraGyagedaPkavipslvgkprgrkvea........klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 +++ +D Gs+++raG++g daP + + s++g p++++++           y+g+ea + r+ l++ +p+++G + +wd+ +  +e+++++ l++  +++
  EFC37747.1   4 ETLTIDLGSHCIRAGFSGSDAPVLNFYSMIGFPKYQTTALnylssyskLSYIGEEANKLRGILSLFHPIDNGKIINWDVLALFFEYTFHN-LNIPLQDS 101
                 5789***************************99999766599****9889*****9999****************************998.******** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvev 194
                  ++l+ep+ n +++r+ +++++fE+f+ ++l +++++v++++++g+++gl+ D+G+s+  v p+++Gyv+++a  ++++gGk ++++l +ll++k    
  EFC37747.1 102 NIMLVEPSSNLKSNRNSLTQLCFESFNSASLGFGNAQVMAMYSAGRTSGLIADCGDSSCRVLPIHEGYVISHASGKLNVGGKSIDKYLGKLLEYK---- 196
                 **********************************************************************************************8.... PP

       Actin 195 tprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligses 293
                                           + ++++++e+e+l+e+Kes++++s+ +e           ++YeLPDg+ i+ + eR+++ E+LF+p+l+g  s
  EFC37747.1 197 --------------------------GINFTSSSEMEILREMKESIVTCSKGEE--------YLVQQYELPDGTLIETSRERYECVECLFNPNLVGISS 261
                 ..........................779********************88887........7899*******************************99 PP

       Actin 294 aleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskq 392
                           gi+eli+++i +c++d + +L++ni+++GG+sl++ ++  l++el q + +  + +ii+p+ er ys+WiG+Si +s+g+++   v k+
  EFC37747.1 262 D--------FGIAELIYNSICKCPIDTKLDLYSNIILSGGTSLIQDFNVKLKQELDQ-LNQRHSFRIISPP-ERNYSSWIGASIVSSMGHMRPYRVHKE 350
                 9........8***********************************************.99999********.*************************** PP

       Actin 393 EYeEqGssvver 404
                  Y+E+G s+++r
  EFC37747.1 351 QYNEYGCSIMDR 362
                 *******99987 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   4.5e-07     0.004       4     297 ..       6     308 ..       3     313 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 4.5e-07
                 EEEEE-SSEEEE.EETTTEEEEEEES-EEEETT..........T--EEEESHHHHTTTTS-GTTEEEE-SEETTEESSHHHHHHHHHHHHHHHHTSS-S CS
    MreB_Mbl   4 lgiDLGtantlv.yvkgkgivlnepsvvAikkk..........tkkvlavGeeAkkmlgktpgnikavrPlkdGviadlevaeellkyfikkvkkkksl 91 
                 l+iDLG+  + + +      vln  s++ + k            +k+  +GeeA+k+ g     ++  +P+ +G i + +v + +++y +++++    l
  EFC37747.1   6 LTIDLGSHCIRAgFSGSDAPVLNFYSMIGFPKYqttalnylssYSKLSYIGEEANKLRG----ILSLFHPIDNGKIINWDVLALFFEYTFHNLNI--PL 98 
                 66666666666633333455666666665544333344444445677788888888765....78999*************99999999998876..48 PP

                 S--EEEEEE-SS--HHHHHHHHHHHHH.TT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-EEEEEEETTEEEEEEE..ES-SHHHHHHHHHHH CS
    MreB_Mbl  92 skprvvicvPsgiteverrAvkeaakk.aGarevllieeplaAAiGaglpveepsgnmvvdiGggttevavislggivtsks..vrvaGdeldeaiiky 187
                 + +++++  Ps+  + +r+ +++ + +   + +    + +++A   ag      ++ ++ d+G  +  v  i  g +++  s  + v+G+++d+ + k+
  EFC37747.1  99 QDSNIMLVEPSSNLKSNRNSLTQLCFEsFNSASLGFGNAQVMAMYSAG-----RTSGLIADCGDSSCRVLPIHEGYVISHASgkLNVGGKSIDKYLGKL 192
                 99999999*****9******9998865156666777777788877777.....56789**************99999987664488********99999 PP

                 HHHHHSEE--HHHHHHHHHHH-BSS--HHHHEEEEEEEETTTTCEEEEEEEHHHHHHHHHHH.HH......HHHHHHHHHHHTS-HHHHHHHHHH-EEE CS
    MreB_Mbl 188 irkkynlliGertaekikieigsavkeeeeekmeikGrdlvtglpkevevsseevrealkep.vs......aiveavkevLektppeLaadivdrgivl 279
                 +  k      +++ e ++    s+v+ ++ e+  ++  +l  g   e++ +  e  e+l +p +        i e + + + k+p +   d++ + i+l
  EFC37747.1 193 LEYKGINFTSSSEMEILREMKESIVTCSKGEEYLVQQYELPDGTLIETSRERYECVECLFNPnLVgissdfGIAELIYNSICKCPIDTKLDLYSN-IIL 290
                 8877555555666666555556666667777888888888888888887777777777755423311122258899****************987.899 PP

                 ESGGGGSBTHHHHHHHHH CS
    MreB_Mbl 280 tGGgallkgldkllseet 297
                 +GG++l+++++  l++e+
  EFC37747.1 291 SGGTSLIQDFNVKLKQEL 308
                 ************999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (367 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       449  (0.0250432); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2176.40
//
Query:       EFC37748.1  [L=687]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (687 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       287  (0.0160076); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 4292.36
//
Query:       EFC37749.1  [L=590]
Description: hypothetical protein NAEGRDRAFT_53578 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0019   18.0   0.2      0.011   15.6   0.0    2.4  2  F-box-like     F-box-like
  ------ inclusion threshold ------
       0.04   13.8   1.7       0.32   10.9   0.1    3.1  2  F-box          F-box domain
      0.087   13.4   1.0       0.25   11.9   1.0    1.8  1  MerR-DNA-bind  MerR, DNA binding


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   1.8e-06     0.011       6      37 ..     108     140 ..     108     145 .. 0.92
   2 ?   -2.2   0.1      0.67     4e+03      10      24 ..     163     177 ..     163     187 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.8e-06
  F-box-like   6 dEiLlqIFsyLpps.dLlrlalVCrrWrrvald 37 
                 d++L+ IF yL+   ++     V++++r+v+++
  EFC37749.1 108 DDVLCNIFAYLNYDfEIFKYLTVSKQFRNVINT 140
                 78*********9888***************964 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.67
  F-box-like  10 lqIFsyLppsdLlrl 24 
                 l+I+s+ +p +Ll l
  EFC37749.1 163 LEILSQYEPDSLLKL 177
                 679998888888876 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   5.3e-05      0.32       7      42 ..     107     143 ..     101     147 .. 0.92
   2 ?    0.0   0.2      0.14   8.4e+02       7      24 ..     171     188 ..     164     189 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 5.3e-05
                 -HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHH CS
       F-box   7 PsevlrhILerLplsd.llalrrVSkgwrilidsdrl 42 
                 +++vl++I+ +L+    ++    VSk +r++i+ ++ 
  EFC37749.1 107 CDDVLCNIFAYLNYDFeIFKYLTVSKQFRNVINTIKN 143
                 689*****************************99986 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.14
                 -HHHHHHHHHTS-HHHHH CS
       F-box   7 PsevlrhILerLplsdll 24 
                 P+ +l+ IL+ ++ ++l+
  EFC37749.1 171 PDSLLKLILKCVNIKHLV 188
                 788999****99999876 PP

>> MerR-DNA-bind  MerR, DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   1.0   4.2e-05      0.25       6      49 ..      17      56 ..      16      62 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.2e-05
                   HHHHHHHTT--HHHHHHHHHHHHSTTTBHHHHHHHHHHHHHHHH CS
  MerR-DNA-bind  6 fIrrarrlGFsLdeIrelLalyddrappcqdvrallarklaele 49
                   fI +++rlG+s ++I el  l+ +   ++++  a ++++ +el 
     EFC37749.1 17 FIEQCQRLGLSSEQIFELWKLKLQ--FTQEE--AKAKARQEELK 56
                   9******************99444..33333..33455555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (590 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1068  (0.0595683); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.68u 0.22s 00:00:00.90 Elapsed: 00:00:00.46
# Mc/sec: 3861.15
//
Query:       EFC37750.1  [L=585]
Description: hypothetical protein NAEGRDRAFT_53581 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.5e-06   28.1   1.5      0.027   15.3   0.1    4.0  3  WD40        WD domain, G-beta repeat
    4.3e-05   23.3   0.2    8.9e-05   22.3   0.2    1.6  1  F-box       F-box domain
      0.002   18.0   0.1      0.004   17.0   0.1    1.5  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.073   13.4   0.0       0.57   10.5   0.0    2.2  2  Corazonin   Pro-corazonin


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.1   0.00065       2.9       6      38 .]     302     334 ..     297     334 .. 0.83
   2 !   15.3   0.1     6e-06     0.027       8      38 .]     352     386 ..     341     386 .. 0.87
   3 ?   -1.7   0.0       1.4   6.4e+03      15      32 ..     409     425 ..     403     429 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00065
                 EEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   6 tltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +   H ++++ l+   +++++ +G+ Dg  +i+d
  EFC37750.1 302 VPHNHkNGIWNLRIINESSFV-TGGADGVAKIFD 334
                 55678888**9*999999997.7999******98 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 6e-06
                 ESS.SSEEEEEEETTSSE...EEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgaw...lasGsdDgtvriWd 38 
                 ++H s +++++ +p+g++   ++++s D+ ++i+d
  EFC37750.1 352 STHkSAIYDVDCNPSGRYsdlFLTASADKYIKIFD 386
                 68*666************998568888******98 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.4
                 EEEEETTSSEEEEEETTS CS
        WD40  15 slafspdgawlasGsdDg 32 
                 +++ s  + ++++Gs D+
  EFC37750.1 409 CFDPSAGKYLFLAGS-DR 425
                 555555555567899.86 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.2     2e-08   8.9e-05       4      48 .]      55     100 ..      52     100 .. 0.95

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 2e-08
                 HHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHHHHHHHH CS
       F-box   4 srLPsevlrhILerLplsd.llalrrVSkgwrilidsdrlwcksir 48 
                  ++P++vl  I+++L+ ++ +l++++V  ++    ++d lw+ +ir
  EFC37750.1  55 TDVPEDVLILIFSFLEYREiILNISLVNSTFLYTSRNDALWKQFIR 100
                 589****************************************996 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.1     9e-07     0.004       4      44 ..      57      97 ..      54     100 .. 0.89

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 9e-07
  F-box-like  4 LPdEiLlqIFsyLppsd.LlrlalVCrrWrrvaldtplLWrr 44
                 P+++L+ IFs+L+ ++ +l+++lV + +    +++  LW++
  EFC37750.1 57 VPEDVLILIFSFLEYREiILNISLVNSTFLYTSRND-ALWKQ 97
                6************99975899********9999999.9**96 PP

>> Corazonin  Pro-corazonin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.29   1.3e+03      60      85 ..      98     123 ..      49     147 .. 0.56
   2 ?   10.5   0.0   0.00013      0.57      39      93 ..     246     300 ..     227     319 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.29
   Corazonin  60 fvlnrllhrsvalnlaredsdsedss 85 
                 f++n++  +s++ + ++ +  ++++s
  EFC37750.1  98 FIRNENNSSSTNDEKTHLEIPPSQKS 123
                 33333333222222222222222222 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00013
   Corazonin  39 ydlqdkssdrrLerCLsqLqrfvlnrllhrsvalnlaredsdsedsseerslnln 93 
                 y+ +++  +r L  C+   q+ + n l++ ++ + l++ + d+e ++ e  +n+ 
  EFC37750.1 246 YEWKETYEERSLLWCIDTQQHRIPNFLVTGGFSNILNYGSYDPEAEDGEIMKNIG 300
                 999*****************************************99998888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (585 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       459  (0.025601); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3469.13
//
Query:       EFC37751.1  [L=270]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.069   13.3   1.1        5.7    7.1   0.7    2.2  2  DUF5125   Domain of unknown function (DUF5125)


Domain annotation for each model (and alignments):
>> DUF5125  Domain of unknown function (DUF5125)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0    0.0018        33       6      26 ..      51      72 ..      47      81 .. 0.82
   2 ?    7.1   0.7   0.00032       5.7      57     104 ..     188     235 ..     155     251 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0018
     DUF5125  6 rPkpa.yltlleegkeyrmeks 26
                 Pkp+  lt+ ++gkey m k 
  EFC37751.1 51 SPKPSlILTVCKNGKEYSMRKR 72
                68888358999********986 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.00032
     DUF5125  57 vtlGyddsakgiaaestsaiPfanseaGeytitfnllaleasPfakll 104
                 v    + s+  i+  s++  P++++ +   t +f+ l+  +sP+++  
  EFC37751.1 188 VQTSSEVSTPVIPLTSSTITPYSSTTTCSITSQFDSLSSPSSPLSSCH 235
                 5555667787899999**9************************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1138  (0.0634726); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1548.09
//
Query:       EFC37752.1  [L=553]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.14   12.2   2.9       0.43   10.6   2.9    1.9  1  TMF_DNA_bd  TATA element modulatory factor 1 DNA binding


Domain annotation for each model (and alignments):
>> TMF_DNA_bd  TATA element modulatory factor 1 DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   2.9   2.4e-05      0.43       3      23 ..     408     428 ..     406     435 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 2.4e-05
  TMF_DNA_bd   3 lekklkeKDeqIaqLmeEGek 23 
                 l+ +l+eKD++I+qL+ E+++
  EFC37752.1 408 LLQQLAEKDAEIKQLQVELKA 428
                 5679************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (553 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1164  (0.0649228); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.54
# Mc/sec: 3067.25
//
Query:       EFC37753.1  [L=263]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
        0.1   12.4   0.1       0.64    9.9   0.0    2.2  2  DUF2073    Uncharacterized protein conserved in archaea (DUF2
       0.27   10.8   3.9       0.61    9.6   3.6    1.7  2  DUF5526    Family of unknown function (DUF5526)
       0.35    9.8   5.2        2.1    7.2   0.7    2.1  2  Peroxin-3  Peroxin-3


Domain annotation for each model (and alignments):
>> DUF2073  Uncharacterized protein conserved in archaea (DUF2073)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00011      0.64      49      78 ..      68      97 ..      44     104 .. 0.84
   2 ?   -0.9   0.0      0.25   1.5e+03      82      99 ..     223     240 ..     219     245 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00011
     DUF2073 49 eFsGieietypkkekdkgllekllgkkese 78
                ++  i+  +yp k+k+k+l++k+++kk++e
  EFC37753.1 68 NYDDIQAGSYPPKSKKKSLFSKIFNKKNHE 97
                67778999******************9755 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.25
     DUF2073  82 tvigPanqlktlkkdkdl 99 
                 t+ g +n+lkt++  +++
  EFC37753.1 223 TLSGAVNKLKTIQNRREI 240
                 566889******988765 PP

>> DUF5526  Family of unknown function (DUF5526)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.18   1.1e+03     140     163 ..      77     101 ..      74     104 .. 0.60
   2 ?    9.6   3.6    0.0001      0.61      52     139 ..     101     187 ..      81     189 .. 0.69

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.18
     DUF5526 140 ykpkakveka.kkvlsesekedqee 163
                 y pk+k+++   k  +++++edqee
  EFC37753.1  77 YPPKSKKKSLfSKIFNKKNHEDQEE 101
                 5566665555566666666677665 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0001
     DUF5526  52 srLvlsrdssQrLpvAraskssak....kktssqsfqleksksedilaealkiqeseekekylqkakkrdeilqLLrkQReeRiskElislp 139
                    v   ++ Qr p+  ++++        +  ++   + k+ks++ l++   i+ s+e        ++ +e  +L rkQR++++ kEl+s++
  EFC37753.1 101 EEVVFFDSTGQRVPIDTTRRTDEGstlvVNDMNHDYFVPKKKSTNSLENVNSINTSNEN-----LPDEEKEARKLKRKQRQDKLWKELMSMK 187
                 55666667889999999888855422232222233333444555556666666655554.....3567788999***************986 PP

>> Peroxin-3  Peroxin-3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.7   0.00035       2.1     117     179 ..     130     185 ..      18     198 .. 0.62
   2 ?    5.0   0.3    0.0017        10       5      27 ..     235     257 ..     233     261 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00035
   Peroxin-3 117 eddskslseeesssssstvsasseassseesaseeseksekeseessskprksKaeLWnelki 179
                 +d +++   ++++s++s  +  ++ ++s+e+ ++e      e+e+++ k+++   +LW+el  
  EFC37753.1 130 NDMNHDYFVPKKKSTNSLEN-VNSINTSNENLPDE------EKEARKLKRKQRQDKLWKELMS 185
                 33333333222333333322.22222323333322......234556677777789****975 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0017
   Peroxin-3   5 rnrrklaitagvvgagYlakqYv 27 
                 +nrr++a+ ++++g+ Yl+ qY+
  EFC37753.1 235 QNRREIAVKTTMTGGKYLIYQYI 257
                 69********************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1462  (0.0815439); expected 358.6 (0.02)
Passed bias filter:                      587  (0.0327403); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 1571.78
//
Query:       EFC37754.1  [L=228]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-14   54.2  34.1    2.7e-10   40.8  33.2    3.3  2  Ku_C            Ku70/Ku80 C-terminal arm
    0.00078   18.8  12.5     0.0012   18.3  12.5    1.2  1  ORC6            Origin recognition complex subunit 6 (ORC6)
     0.0099   16.0   8.3      0.011   15.8   8.3    1.2  1  Neur_chan_memb  Neurotransmitter-gated ion-channel transmembr
  ------ inclusion threshold ------
      0.012   15.0  28.8      0.014   14.9  28.8    1.1  1  CDC27           DNA polymerase subunit Cdc27
      0.054   13.3  21.3      0.073   12.9  21.3    1.2  1  RR_TM4-6        Ryanodine Receptor TM 4-6
      0.072   12.4  11.5      0.099   11.9  11.5    1.2  1  DUF4678         Domain of unknown function (DUF4678)
      0.094   11.5  13.2       0.11   11.3  13.2    1.1  1  SAPS            SIT4 phosphatase-associated protein
       0.24   11.0   5.0        0.3   10.7   5.0    1.2  1  DUF2201_N       Putative metallopeptidase domain
       0.38    9.5  15.6       0.46    9.2  15.6    1.1  1  Presenilin      Presenilin
       0.56    9.4  12.5       0.77    8.9  12.5    1.1  1  Zip             ZIP Zinc transporter
       0.66   10.2  15.5       0.83    9.9  15.5    1.2  1  GAGA_bind       GAGA binding protein-like family
       0.81    9.2  12.9          1    8.9  12.9    1.2  1  VIR_N           Virilizer, N-terminal
        1.2    7.8   6.9        1.2    7.7   6.9    1.1  1  Ndc1_Nup        Nucleoporin protein Ndc1-Nup
          2    7.1  18.5        2.9    6.6  18.5    1.2  1  NPR3            Nitrogen Permease regulator of amino acid tra
        3.3    6.6  20.7        4.1    6.3  20.7    1.1  1  DUF5427         Family of unknown function (DUF5427)
        3.3    7.0  13.0        4.5    6.6  13.0    1.2  1  DUF908          Domain of Unknown Function (DUF908)
        4.3    6.2  16.7        6.1    5.7  16.7    1.1  1  Peroxin-3       Peroxin-3
        6.4    6.8  25.0        7.9    6.5  25.0    1.2  1  Asp-B-Hydro_N   Aspartyl beta-hydroxylase N-terminal region
          9    5.1  19.7         10    4.9  19.7    1.3  1  XRN_M           Xrn1 helical domain


Domain annotation for each model (and alignments):
>> Ku_C  Ku70/Ku80 C-terminal arm
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.8  33.2   2.9e-13   2.7e-10       1      77 [.      29     112 ..      29     195 .. 0.85
   2 ?   -2.2   0.1       7.6   7.1e+03      33      47 ..     190     205 ..     167     219 .. 0.48

  Alignments for each domain:
  == domain 1  score: 40.8 bits;  conditional E-value: 2.9e-13
                 ---GGG---HHHHHHHHHHHHHHTT---..---SS--HHHHHHHHH-....HHHHHHHHHHHHH...HHHHH............. CS
        Ku_C   1 sydpskfpNPsLqrhykiLqalAldedlpeeledktlpkyeaidkragslleewkelfeleeedke.kkkekrkaed.......e 77 
                 +++p++f NPsLq++y+ LqalAl+   +e++ed ++p++e + k+ ++l++e+k+++ + ++d++ kk +k ++ +       e
  EFC37754.1  29 DFNPHEFTNPSLQQFYQSLQALALEHSNIEQIEDVLKPDKEGM-KKYENLMNEFKDMIFPSDYDPDsKKLTKSTTRTssskvkkE 112
                 69*************************************5555.8999*****************76555555544322244321 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 7.6
                 -SS--HH.HHHHHHH- CS
        Ku_C  33 edktlpk.yeaidkra 47 
                 +dk++ +  +++ k+ 
  EFC37754.1 190 ADKLKVDiLKEFCKQY 205
                 3344333334444444 PP

>> ORC6  Origin recognition complex subunit 6 (ORC6)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3  12.5   1.2e-06    0.0012      72     172 ..      72     178 ..      70     214 .. 0.51

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 1.2e-06
        ORC6  72 kaykklldlfrqsLsnss..........satstPskspsspst.....dpkslrkqlfsTPtKsktlktalsasksssplkrrrklaneedgeeeeeda 155
                 k+y++l+++f++++++s           s+t+t s++ ++  +      +++ +    sT  K+++        k+   +k+r+k+   e++eeeee++
  EFC37754.1  72 KKYENLMNEFKDMIFPSDydpdskkltkSTTRTSSSKVKKEEEeeattAAADSQDVSESTSKKKTAT------RKKTNDSKKRKKA---EESEEEEEKK 161
                 89****************8888764444444444333333333444332222222222222222221......2222233333333...3333333344 PP

        ORC6 156 pswvstsirdsrpeisr 172
                 p++ ++++++s++e+++
  EFC37754.1 162 PKKKKAELSESDEEEEE 178
                 44444444433333333 PP

>> Neur_chan_memb  Neurotransmitter-gated ion-channel transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   8.3   1.1e-05     0.011     122     224 ..      97     218 ..       9     226 .. 0.61

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.1e-05
                     ..................--------------------------------------SS---TTGGG--.....-----TTTTTHHHHHHHHHHHH CS
  Neur_chan_memb 122 l.................ssgasseaeelilskskseskkaklseeqgsekastckckckegeeaspstqlskeelspelkkavegvkyiadhlr 199
                     l                 ++ ++ +a++ ++s+s s  kk+  +++ +++k+ +++ +++e+ee++p++++ + + s+e ++ ++ v+ i+d   
      EFC37754.1  97 LtksttrtssskvkkeeeEEATTAAADSQDVSESTS-KKKTATRKKTNDSKKRKKAEESEEEEEKKPKKKKAELSESDEEEEEIDMVQLIKDGKA 190
                     144444444322221111222222222222222222.233333333333333333333334444444444444888889999********98777 PP

                     HH...HHHHHHHHHHHHHHHHHHHHHHH CS
  Neur_chan_memb 200 ae...dedksvkedwkyvamviDriflw 224
                     ++   d  k+  ++ k+  m+iD+if +
      EFC37754.1 191 DKlkvDILKEFCKQYKLKMMKIDHIFEL 218
                     66211445677788999*******9965 PP

>> CDC27  DNA polymerase subunit Cdc27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9  28.8   1.4e-05     0.014     175     312 ..      86     180 ..       4     210 .. 0.50

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.4e-05
       CDC27 175 skkksaekskdaskettkekaekaasskaaslkkkasaksnimksffkakpaekkkkteakeqkveeeseeekekedkeleddsaaeeeeeeekstkke 273
                 ++++  + sk+ +k tt  +  k  ++++++  + a +++++ +s +k+k+a +kk + +k+ k++eeseee                           
  EFC37754.1  86 FPSDYDPDSKKLTKSTTRTSSSKVKKEEEEEATTAAADSQDVSESTSKKKTATRKKTNDSKKRKKAEESEEE--------------------------- 157
                 333333344444444444444444444444444444444444444444444444444444444444444444........................... PP

       CDC27 274 krrqkklessdeeeeerekekekrkrlkkmmeDededd.e 312
                                  e++k k+k+++  ++De+e++ +
  EFC37754.1 158 -----------------EEKKPKKKKAELSESDEEEEEiD 180
                 .................44455556666666666655522 PP

>> RR_TM4-6  Ryanodine Receptor TM 4-6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9  21.3   7.7e-05     0.073      33     162 ..      49     183 ..      29     210 .. 0.48

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 7.7e-05
                 X...XXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX.... CS
    RR_TM4-6  33 eaageeeeedllsdvfgldlkkeggqykvvakkseagLgDlseteaeesptpelkkklaeeeeaeeekeeeeepeaeaeekadaengekeekeke.... 127
                  +a e+++ + ++dv  l+++keg ++   +++  + + D+   +  ++ + +l k +++ +++++ k+eeee ea++  +ad+++ ++++++k+    
  EFC37754.1  49 ALALEHSNIEQIEDV--LKPDKEGMKK---YENLMNEFKDMIFPSDYDPDSKKLTKSTTR-TSSSKVKKEEEE-EATT-AAADSQDVSESTSKKKtatr 139
                 455666667777777..5566777633...466666677777777666654222222221.111111111111.1111.22222222222222222223 PP

                 ...................XXXXXXXXXXXXXXXXXXXXXXXXX CS
    RR_TM4-6 128 .........keeeekeseeeeeekkkkkkakskkkeeaeaeese 162
                          k++ee+e+eee+++kkkk++ +++ +ee+e  + +
  EFC37754.1 140 kktndskkrKKAEESEEEEEKKPKKKKAELSESDEEEEEIDMVQ 183
                 33444432233333333333444444444444444444444444 PP

>> DUF4678  Domain of unknown function (DUF4678)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9  11.5    0.0001     0.099      10      92 ..      96     179 ..      88     197 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.0001
     DUF4678  10 rssdspaggsqsqvsltadlvassaaasaerqdvdqasv..ksatseatsasGdkdke.evaaeksqepkevtalllrqapealqv 92 
                 + + s++ +s s+v+   +   ++++a a+ qdv++ +   k+at + t  s  ++k  e ++e++++pk+ +a l + + e+ ++
  EFC37754.1  96 KLTKSTTRTSSSKVKK--EEEEEATTAAADSQDVSESTSkkKTATRKKTNDSKKRKKAeESEEEEEKKPKKKKAELSESDEEEEEI 179
                 45789********996..55667777888889998765411567777777777776662555666677********9998877655 PP

>> SAPS  SIT4 phosphatase-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3  13.2   0.00011      0.11     263     344 ..      76     185 ..      22     216 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00011
        SAPS 263 seeealedvs.....................deaskeesaesedltdkdedvsleesksakdenkesdesesdtaeesseededdasseesalaeetee 340
                 ++ ++++d++                     ++ +kee++e++  + + +dvs+++sk+++++ k+ ++s++ ++ e+see+e++++++++a+ +e++e
  EFC37754.1  76 NLMNEFKDMIfpsdydpdskkltksttrtssSKVKKEEEEEATTAAADSQDVSESTSKKKTATRKKTNDSKKRKKAEESEEEEEKKPKKKKAELSESDE 174
                 223333333377777777777777777765544445555555555556667777777777776666666666666666666666666666665555555 PP

        SAPS 341 klr.......k 344
                 + +        
  EFC37754.1 175 EEEeidmvqlI 185
                 55434455551 PP

>> DUF2201_N  Putative metallopeptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   5.0   0.00032       0.3     134     210 ..      84     192 ..      17     206 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00032
   DUF2201_N 134 l.................................ggadrdgekkgdgekaakkkrsdspesarvgalatgfeadleesekgksseeeeseearewreal 199
                 +                                  +a+ d ++  +   ++k+   ++++ +++++ a+++e++ e ++k+k++e  es+e+ e    +
  EFC37754.1  84 MifpsdydpdskkltksttrtssskvkkeeeeeaTTAAADSQDVSESTSKKKTATRKKTNDSKKRKKAEESEEEEEKKPKKKKAELSESDEE-EEEIDM 181
                 15555555555555666666555554444444443344444444445555555556668899999999999999998888888887888877.667777 PP

   DUF2201_N 200 qraleagkaqg 210
                 ++  + gka+ 
  EFC37754.1 182 VQLIKDGKADK 192
                 77788888765 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2  15.6   0.00049      0.46     223     308 ..      93     176 ..      69     209 .. 0.37

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00049
  Presenilin 223 laaeekkaevaeseeeeeaekkkeeasesskeeeseeesseksaqsse.....seeeseeesseaessaeesseekeseessesseeeeee 308
                  ++     + ++s+++++++k k+e++e+ ++++++++  ++s+++++     ++++s+++++++es++ee++++k+++++ ++s+ee  e
  EFC37754.1  93 DSK-----KLTKSTTRTSSSKVKKEEEEEATTAAADSQDVSESTSKKKtatrkKTNDSKKRKKAEESEEEEEKKPKKKKAELSESDEE--E 176
                 222.....22222222222222222222222222222222222222211111011222222222222222222222222222111111..1 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9  12.5   0.00082      0.77      97     179 ..      83     176 ..      74     188 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00082
         Zip  97 tmivek.........ksshkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqas.....eeedkekl 179
                  mi+++         ++s  +++++k +++++e+a+   ++++ v+es+ k++ ++ ++t++++k +++++++e +e+++++++     +   +e+ 
  EFC37754.1  83 DMIFPSdydpdskklTKSTTRTSSSKVKKEEEEEATTAAADSQDVSESTSKKKTATRKKTNDSKKRKKAEESEEEEEKKPKKKKaelseS---DEEE 176
                 45555566666666667788899999999999999999999*****************************99999999999888664331...3333 PP

>> GAGA_bind  GAGA binding protein-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9  15.5   0.00088      0.83      65     194 ..      56     181 ..       4     198 .. 0.46

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00088
   GAGA_bind  65 aflrrdaalaere...kvlnvlpvnkakalleednalaalqmlrplesqlqeaeapelekeevasselveesavvekeeaakkrqqgkrpkepkakkak 160
                 ++ + +  l++ +   k +++l  + +  ++++d    + +++++ ++++++++  ++e+ee+a++ + +++ v e  +++kk+++  r+k++ +kk k
  EFC37754.1  56 NIEQIEDVLKPDKegmKKYENLMNEFKDMIFPSDYDPDSKKLTKS-TTRTSSSK-VKKEEEEEATTAAADSQDVSE--STSKKKTA-TRKKTNDSKKRK 149
                 333334444433334444445555555666666665555555432.22222222.233333333333333333333..55555544.567777777777 PP

   GAGA_bind 161 kaarkpkeegedlalkkakrsksekksvdlving 194
                 ka++  +ee+++ ++kka+ s s+ ++ +  i+ 
  EFC37754.1 150 KAEESEEEEEKKPKKKKAELSESDEEEEE--IDM 181
                 74444444443333333333333333333..332 PP

>> VIR_N  Virilizer, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9  12.9    0.0011         1     155     246 ..      83     172 ..      22     184 .. 0.49

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0011
       VIR_N 155 spvrpeprePrtpelipaytgnvastpPpdddeeedaavpetveeekeensekredyleeesPeertslkaeekdseaereeresseeierd 246
                 + + p++ +P + +l  + t++ +s +  +++eee a++ ++ +++ +e++ k+++ ++++  +++ + kaee++ e+e++ ++++ e +++
  EFC37754.1  83 DMIFPSDYDPDSKKLTKS-TTRTSSSKVKKEEEEE-ATTAAADSQDVSESTSKKKTATRKKTNDSKKRKKAEESEEEEEKKPKKKKAELSES 172
                 333344444444432222.2233333332222222.23333333344444444444444444444444444444444444444443333333 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   6.9    0.0013       1.2     395     467 ..      88     198 ..      20     220 .. 0.48

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0013
    Ndc1_Nup 395 n.........sltaeaspkssssskegvekalsslakspgqspsptarlsprarkllekaksrllskeqkealsestikkk.................. 466
                 +         +++++++++s+  +ke+ e+a++++a s+  s s++++ +++ +k+ + +k+r +  e++e+ +e+++kkk                  
  EFC37754.1  88 SdydpdskklTKSTTRTSSSK-VKKEEEEEATTAAADSQDVSESTSKKKTATRKKTND-SKKRKKA-EESEEEEEKKPKKKkaelsesdeeeeeidmvq 183
                 233333332211222222222.334444444444554444332222222222222222.2222222.22222222222222344444444455555555 PP

    Ndc1_Nup 467 ..............v 467
                               +
  EFC37754.1 184 likdgkadklkvdiL 198
                 555555555444442 PP

>> NPR3  Nitrogen Permease regulator of amino acid transport activity 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6  18.5    0.0031       2.9       7     130 ..      60     180 ..      55     186 .. 0.42

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0031
        NPR3   7 laellsPerelcntrFeltvDdlaFlGlPvhvdedgkwrkskkkkkkskrkrssrskekkskesskksesssksesseekksskeseeseekesneeee 105
                 ++++l P++e   +++e  ++++  + +P   d+d k  ++++ +++s++ ++++++e+++   ++++ s+s+s+++++++++ +++++++k +++eee
  EFC37754.1  60 IEDVLKPDKEGM-KKYENLMNEFKDMIFPSDYDPDSKKLTKSTTRTSSSKVKKEEEEEATTAAADSQDVSESTSKKKTATRKKTNDSKKRKKAEESEEE 157
                 566666666654.35677777777777777777776544444444444444444444444443333333333333333322222222222222222222 PP

        NPR3 106 eeededdeesekeeeekedkkknlt 130
                 ee++ +++++  e +e++++++++ 
  EFC37754.1 158 EEKKPKKKKA--ELSESDEEEEEID 180
                 2222222222..2233333333333 PP

>> DUF5427  Family of unknown function (DUF5427)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3  20.7    0.0043       4.1      47     128 ..      96     177 ..      42     187 .. 0.45

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0043
     DUF5427  47 esrpaTPrvksnkskkaspkkkksaeepakeekkkeeessedk...rksvestrsleasetpseeeseeqeaekkeeeeeeaeee 128
                 +  ++T r++s+   k +++++++a++ a +++  +e++s++k   rk ++++++ +++e+++eee+++ +++k+e +e+++eee
  EFC37754.1  96 KLTKSTTRTSSS---KVKKEEEEEATTAAADSQDVSESTSKKKtatRKKTNDSKKRKKAEESEEEEEKKPKKKKAELSESDEEEE 177
                 222233444444...3333333333333333333344444433455444444443444444444433334444443333333333 PP

>> DUF908  Domain of Unknown Function (DUF908)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6  13.0    0.0047       4.5      68     236 ..      31     209 ..       6     221 .. 0.47

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0047
      DUF908  68 asrtvqqallanhynisldrllklAqpfpktpvsdssakaasekkastteyaldlvslakedskvlpsewgdvkvtYYkkssseeqkaesksskeease 166
                 ++ ++ + +l++ y+     l++lA   +++ + +   k+ +e  ++ +   +++ +++  ++    +++++++ +  ++sss+ +k+e+++++++a+ 
  EFC37754.1  31 NPHEFTNPSLQQFYQ----SLQALALEHSNIEQIEDVLKPDKEGMKKYENLMNEFKDMIFPSDY--DPDSKKLTKSTTRTSSSKVKKEEEEEATTAAAD 123
                 333444444555555....666666666666666655555555555555567888888887764..455666666556666666666666555555555 PP

      DUF908 167 sli....ssspstPtplrrssklgkts........sspsspaktstpskaaksqeglktfeipesevsskslyellakave.....k 236
                 s++    +s+++t t++++++++++ +        ++++ ++k+ + s++++++e+  ++++ ++  + k  +++l++ ++      
  EFC37754.1 124 SQDvsesTSKKKTATRKKTNDSKKR-KkaeeseeeEEKKPKKKKAELSESDEEEEEIDMVQLIKDGKADKLKVDILKEFCKqyklkM 209
                 5554433222222222222222221.0223333322222222222223333333333344444444444445666666665554444 PP

>> Peroxin-3  Peroxin-3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7  16.7    0.0064       6.1      75     173 ..      52     169 ..      42     171 .. 0.55

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0064
   Peroxin-3  75 lealdvEeitqeLqqkkaeraarsseakseee..................kssaspsvededd..skslseeesssssstvsasseassseesaseese 153
                 le+ ++E+i   L+  k+  ++ ++  ++ +                   + ++s++v++e++    +++ ++++ s+st++ +++a++++++ s++++
  EFC37754.1  52 LEHSNIEQIEDVLKPDKEGMKKYENLMNEFKDmifpsdydpdskkltkstTRTSSSKVKKEEEeeATTAAADSQDVSESTSK-KKTATRKKTNDSKKRK 149
                 6677777777777777766555544443333367777777777666655433333333333332133333334444444443.3334444444444444 PP

   Peroxin-3 154 ksekeseessskprksKaeL 173
                 k e+++ee+++kp+k+KaeL
  EFC37754.1 150 KAEESEEEEEKKPKKKKAEL 169
                 455557999999******98 PP

>> Asp-B-Hydro_N  Aspartyl beta-hydroxylase N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  25.0    0.0084       7.9     104     235 ..      55     183 ..       8     192 .. 0.66

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0084
  Asp-B-Hydro_N 104 evkEqlkkvkeeivvkeeeeegieeepqleeekkllkedsderqeel...eagkvkeevEeslkveetvseeakkdmkekaseeenekskepveea 196
                       Eq++ v     ++++e  ++ e++ +e ++ ++ +d d   ++l    + ++  +v ++ ++e t+  ++++d+ e +s+++++  k++   +
     EFC37754.1  55 SNIEQIEDV----LKPDKEGMKKYENLMNEFKDMIFPSDYDPDSKKLtksTTRTSSSKVKKEEEEEATTAAADSQDVSESTSKKKTATRKKTNDSK 146
                    444444443....33334444555555555566666666554444330003333444444444567778888999999999999999999999999 PP

  Asp-B-Hydro_N 197 ekekaeakeveeedkeeeaeedekveeskaieeelaeek 235
                    +++kae++e eee+k+++  +++++ es ++eee+ + +
     EFC37754.1 147 KRKKAEESEEEEEKKPKK--KKAELSESDEEEEEIDMVQ 183
                    999999999999998888..5777888888888876654 PP

>> XRN_M  Xrn1 helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9  19.7     0.011        10      88     174 ..     102     189 ..      29     212 .. 0.65

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.011
       XRN_M  88 drkekklakeeeaskedaaneeaavaeeklseskvaksaeaeaeaea.eaeaeakaekekrekaekeleeseeeeeeeDkvrLgeeGy 174
                  r+++++ k+ee++++ +a+++++   e++s++k+a++++++ ++++ +ae+ +++e++k +k ++el+es eeeee D v+L ++G 
  EFC37754.1 102 TRTSSSKVKKEEEEEATTAAADSQDVSESTSKKKTATRKKTNDSKKRkKAEESEEEEEKKPKKKKAELSESDEEEEEIDMVQLIKDGK 189
                 22222222222222222222223333333444444444444333333034444444455556667778888889999*******9995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3656  (0.203915); expected 358.6 (0.02)
Passed bias filter:                      851  (0.047465); expected 358.6 (0.02)
Passed Vit filter:                       262  (0.0146132); expected 17.9 (0.001)
Passed Fwd filter:                        70  (0.00390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.98u 0.39s 00:00:01.37 Elapsed: 00:00:00.53
# Mc/sec: 1289.18
//
Query:       EFC37755.1  [L=785]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-26   92.3   1.0    3.3e-24   86.2   0.0    2.7  2  Patatin   Patatin-like phospholipase


Domain annotation for each model (and alignments):
>> Patatin  Patatin-like phospholipase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.8   0.2    0.0031        56      75     165 ..      24     120 ..       4     123 .. 0.75
   2 !   86.2   0.0   1.8e-28   3.3e-24       1     204 []     389     640 ..     389     640 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.0031
     Patatin  75 laanlaarlsgllgkgglfdaealrellrkvladktlkrlsarlgklpllks......lftanqavpaittataatastanranglytedddddvdl 165
                 la  + ++ s+ +  g  fd+ +l+++l+++++ +++   ++  ++l +lk+      + + n+ +p++  ++ + +s+++++++     + d++++
  EFC37755.1  24 LALLKCKLSSERTLHGLGFDGSNLQTYLDAHINVDQFLLQIFSHQQLDTLKGaaiagfTKLLNTWNPSNSNNNSNNTSSTTTTTDKVYTPQQDTMSV 120
                 555555566666666777999********99999999999999999999999777777777778888888888888888888887777777777766 PP

  == domain 2  score: 86.2 bits;  conditional E-value: 1.8e-28
     Patatin   1 LvlsGGGsrgafslgalkaL....kkelgerfdiisGtSaGAiialllalgrdpaalvddlrnlllnkifdrdllirelaanlaarlsgllgkgglfda 95 
                 L+++GGG+rg+    +l+++    + +l++ fd+++GtS+GA+++ ++ +g + +++   + +l  + + ++ +l  ++ + +    sg + +g++++a
  EFC37755.1 389 LCMDGGGTRGLILSIILREIekrtNRKLNDIFDLVCGTSTGALTSRCVQSGLSGEEIQTLYTQLATDIFSSKLILNEKITKFYKTVSSGNWYEGSKLEA 487
                 9******************6666799*************************999998888888888888888877777777777777777777777777 PP

     Patatin  96 ealrellr......kv............ladktlkrlsarlgklpllks.........lftanqavpaittataatastanranglytedddddvdlad 167
                   l+++ r       +            + +  +                        ++    +++++t  + ++ + ++++ +l  e+   d++++ 
  EFC37755.1 488 LTLSKISRskendiLYlqdlyqikpkafFVSTLV--------------PstlslqsmsDNNSINNNTNNTSTSSNQSNNNTTSGQLEYERARSDEPISY 572
                 7777777755543311333222222222111111..............122233444444444444444444444444444444444444444444444 PP

     Patatin 168 ...............................avraSsafPglfppvsldgelyvDGGilsNvPilaal 204
                                                 +raS+a+P++f+  +++  +++DGGi++N+P+++a+
  EFC37755.1 573 ifrtypcpfnkenqptrykgtwngqniplssCLRASTAAPVYFDKKRIGNSHFIDGGICNNNPTEIAI 640
                 5555555555555555555555555555555**********************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (785 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1042  (0.0581181); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.76u 0.34s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 4535.51
//
Query:       EFC37756.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       908  (0.0506442); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2500.46
//
Query:       EFC37757.1  [L=704]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0067   15.7   0.4      0.017   14.3   0.4    1.6  1  XendoU    Endoribonuclease XendoU


Domain annotation for each model (and alignments):
>> XendoU  Endoribonuclease XendoU
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.4   9.6e-07     0.017      81     172 ..     563     655 ..     554     683 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 9.6e-07
      XendoU  81 teeerkeeeafLdaileTkvmkelhqflv....skglvssseaefkkqLkeiWFklysrskgkedsSgFEhvfvgEikngevsGlHnWiqfyleek 172
                 +e+ ++e+ a+L++i+++ v++++++ ++    +k++ ++++++  ++Lke+ F+ y+r +     S+ + vf    k ++ +   + i++++ e+
  EFC37757.1 563 SESMKQEIAALLEKIIDSGVIQSIYEVIQksaeKKDKKKQDKQSQSHDLKEFCFNRYTRFGCI---SSLNTVFQTSGKCNDTTVRTKLINLITSEQ 655
                 667899*******************999843323455889999999*************7654...777888776555555444455555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (704 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1847  (0.103017); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.77u 0.30s 00:00:01.07 Elapsed: 00:00:00.49
# Mc/sec: 4328.83
//
Query:       EFC37758.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.6e-20   71.3   1.0      1e-19   70.2   1.0    1.6  1  CSN7a_helixI  COP9 signalosome complex subunit 7a helix I dom
    3.8e-07   30.6   0.6    1.1e-06   29.1   0.4    1.8  1  PCI           PCI domain
     0.0017   18.7   7.7     0.0035   17.7   2.9    2.3  2  DUF4200       Domain of unknown function (DUF4200)
  ------ inclusion threshold ------
      0.024   14.5   1.4      0.069   13.0   1.4    1.8  1  Nsp1_C        Nsp1-like C-terminal region
      0.032   14.3   0.2          5    7.2   0.0    2.4  2  TetR_C_2      MAATS-type transcriptional repressor, C-termina
       0.49   10.5   5.4       0.36   10.9   1.8    2.4  2  DUF1154       Protein of unknown function (DUF1154)
        2.3    8.3   6.3         12    6.1   1.9    2.1  2  GIDA_assoc    GidA associated domain


Domain annotation for each model (and alignments):
>> CSN7a_helixI  COP9 signalosome complex subunit 7a helix I domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.2   1.0   3.9e-23     1e-19       1      50 []     163     212 ..     163     212 .. 1.00

  Alignments for each domain:
  == domain 1  score: 70.2 bits;  conditional E-value: 3.9e-23
  CSN7a_helixI   1 DigaIistLqeWcdsCeaiLsciEtqverANaeknkaikhkekieqEvaN 50 
                   Di+++is+L++W++++++iL++i+++ve+AN++++++++hk+k+e+E+aN
    EFC37758.1 163 DIDQMISVLKNWTVGAKEILKGIDANVEYANKQFKEHNEHKKKYEKEIAN 212
                   9************************************************9 PP

>> PCI  PCI domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.1   0.4   4.2e-10   1.1e-06      32     103 ..      79     151 ..      56     153 .. 0.88

  Alignments for each domain:
  == domain 1  score: 29.1 bits;  conditional E-value: 4.2e-10
                 HTTHHHHHHHHHHHHHHHHHHHHHHCESEEEHHHHHHHHTSSH.HHHHHHHHHHHHTTSSSEEEETTTTEEEE CS
         PCI  32 ddglaqllesLekkvrerllrqvskiyssislerlaklldlsv.devEkilvklIrdgeirakidqesgivvf 103
                  ++ +ql e+  +k+++ ++ +++ + + +++e+l + ld+++  e+E  l++++++g++++k+dq+s+ +++
  EFC37758.1  79 PQNYSQLSEKNLNKLKQLSIVTLASKSRLLKYEDLLRELDITNvRELEDTLIDCMYQGLLEGKLDQKSKWMEV 151
                 34557899*************************************************************9987 PP

>> DUF4200  Domain of unknown function (DUF4200)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.2      0.04     1e+02      15      64 ..      75     124 ..      69     129 .. 0.86
   2 !   17.7   2.9   1.4e-06    0.0035      41      91 ..     169     219 ..     137     226 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.04
     DUF4200  15 leakkeeiqrleealkqreeelekkeqeleedllkfdkflkendakrara 64 
                 ++a  +++ +l e++ ++ ++l       + +llk++  l+e d   +r 
  EFC37758.1  75 YKANPQNYSQLSEKNLNKLKQLSIVTLASKSRLLKYEDLLRELDITNVRE 124
                 66777899999999999999999999999***********9999877765 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 1.4e-06
     DUF4200  41 qeleedllkfdkflkendakraralkkaeeerklkkekeaeikklkaeiet 91 
                 + l++  +  ++ lk +da+ ++a+k+ +e +++kk++e+ei++++++i++
  EFC37758.1 169 SVLKNWTVGAKEILKGIDANVEYANKQFKEHNEHKKKYEKEIANIEESIKA 219
                 567777888899***********************************9987 PP

>> Nsp1_C  Nsp1-like C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   1.4   2.7e-05     0.069      57     114 ..     166     223 ..     158     225 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.7e-05
      Nsp1_C  57 ekIskLysevleaeqeqnkidqeLeyiesqqdeLeslLdnyEkeleellsklesqksd 114
                 ++Is L++ ++ a++  + id + ey ++q +e ++  ++yEke+ ++ ++++ + +d
  EFC37758.1 166 QMISVLKNWTVGAKEILKGIDANVEYANKQFKEHNEHKKKYEKEIANIEESIKASIED 223
                 6899*******************************************99988877665 PP

>> TetR_C_2  MAATS-type transcriptional repressor, C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0     0.002         5      46      78 ..     113     145 ..     104     155 .. 0.86
   2 ?    4.9   0.0     0.011        27      33      69 ..     188     224 ..     166     245 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.002
    TetR_C_2  46 irkelllaeysrleevlqeciekgllpanldlr 78 
                   +el + +  +le++l++c+ +gll  +ld +
  EFC37758.1 113 LLRELDITNVRELEDTLIDCMYQGLLEGKLDQK 145
                 5688999999*******************9976 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.011
    TetR_C_2  33 KCEFvgemsavleirkelllaeysrleevlqeciekg 69 
                   E+ +   ++++ +k+ +++e +++ee+++++ie +
  EFC37758.1 188 NVEYANKQFKEHNEHKKKYEKEIANIEESIKASIEDE 224
                 5799999999**********************99876 PP

>> DUF1154  Protein of unknown function (DUF1154)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.53   1.3e+03      26      33 ..      58      65 ..      57      65 .. 0.91
   2 ?   10.9   1.8   0.00014      0.36      23      41 ..     193     211 ..     189     214 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.53
     DUF1154 26 qKElesLk 33
                qK+l++Lk
  EFC37758.1 58 QKDLNTLK 65
                9*****98 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00014
     DUF1154  23 KKQqKElesLkKkhsKers 41 
                  KQ KE ++ kKk++Ke +
  EFC37758.1 193 NKQFKEHNEHKKKYEKEIA 211
                 6***************965 PP

>> GIDA_assoc  GidA associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.5     0.007        18      84     173 ..      76     164 ..      45     168 .. 0.60
   2 ?    6.1   1.9    0.0045        12     102     161 ..     164     225 ..     144     228 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.007
                 EEHHHHHHHH...HHHT....EHHHHCTTST-.-HHHHHCCHHHHHHHSCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHTSB--TTS-CCCS CS
  GIDA_assoc  84 klkseewkkl..lekkeskklslaellkrpev.kledlleelpeeeeeseeeleqveieakYegyiekqeeeieklkkeenlkipedldYski 173
                 k ++++ ++l  ++ ++ k+ls++ l +++++ k+edll+el   + ++ +ele   i++ Y+g++e + ++ +k+ +  ++ i +d++ ++i
  EFC37758.1  76 KANPQNYSQLseKNLNKLKQLSIVTLASKSRLlKYEDLLREL---DITNVRELEDTLIDCMYQGLLEGKLDQKSKWMEVYET-IGRDIKLDDI 164
                 333333333321222223333666666654444888885544...45677889999**********9998888877665444.6666666555 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0045
                 ..EHHHHCTTST--HHHHHCCHHHHHHHSCHH.HHHHHHHHHCHHHHHHHHHHCHHHHHHHT CS
  GIDA_assoc 102 l.slaellkrpevkledlleelpeeeeeseee.leqveieakYegyiekqeeeieklkkeen 161
                 + +++++lk+ +v  +++l+ ++++ e+ +++ +e+ e + kYe+ i++ ee+i++  ++en
  EFC37758.1 164 IdQMISVLKNWTVGAKEILKGIDANVEYANKQfKEHNEHKKKYEKEIANIEESIKASIEDEN 225
                 147889999999999999999999999999999999***********999999998877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1783  (0.0994478); expected 358.6 (0.02)
Passed bias filter:                      730  (0.0407162); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.44
# Mc/sec: 1760.13
//
Query:       EFC37759.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-39  135.1   0.8    1.7e-39  135.1   0.8    1.5  2  Nup54            Nucleoporin complex subunit 54
    1.8e-05   24.5   0.7    1.8e-05   24.5   0.7    1.8  2  Nup54_C          Nup54 C-terminal interacting domain
    0.00014   20.6  28.0    0.00014   20.6  28.0    1.7  2  Nucleoporin_FG2  Nucleoporin FG repeated region
  ------ inclusion threshold ------
        0.2   11.8   0.9       0.39   10.9   0.1    1.9  2  Parvo_coat_N     Parvovirus coat protein VP1
       0.41   11.2   6.0        1.9    9.0   0.1    2.8  3  Spectrin         Spectrin repeat
       0.67   10.5   5.7       0.62   10.6   3.4    2.0  2  APG6_N           Apg6 coiled-coil region
       0.86    8.9   5.8      0.059   12.7   0.4    1.7  2  FAM76            FAM76 protein
        4.6    7.9   6.3         16    6.1   1.0    2.5  2  Syntaxin-6_N     Syntaxin 6, N-terminal
        9.7    6.7   7.4         18    5.9   3.6    2.9  2  Carbpep_Y_N      Carboxypeptidase Y pro-peptide


Domain annotation for each model (and alignments):
>> Nup54  Nucleoporin complex subunit 54
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  135.1   0.8   8.6e-43   1.7e-39       4     139 ..     173     308 ..     171     309 .. 0.98
   2 ?   -3.1   0.1       3.9   7.7e+03     111     121 ..     343     353 ..     326     371 .. 0.46

  Alignments for each domain:
  == domain 1  score: 135.1 bits;  conditional E-value: 8.6e-43
                 T--HHHHHHHHHT-SST.TEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-S CS
       Nup54   4 gvdeekWeeAleenPdpeklvPvpvkGFedLakRvkaQqkevaqhrerlkeisdrleeleqkhqletsvrlekakkrhvelshRllrllrkleilrsrg 102
                  +++e W++A+e+nPdp++lvP+p+++F+d+++Rv++Qqk +++++  lk + ++++e ++kh+++t +r+  +k+rh+ lshR+l++ +kle+l ++g
  EFC37759.1 173 SINPELWRQAMEKNPDPSRLVPIPATSFKDVKDRVEKQQKRIELMNDFLKVLDSKISECKTKHEADTMSRIGGIKQRHTDLSHRILKIQSKLEVLTQSG 271
                 57899********************************************************************************************** PP

                 S---SSHHHHHHHHHHHHHHHS-HHH.HHHHHHHHHH CS
       Nup54 103 yaldaeEeelrarletleaqlndpaqlkgrvnelwar 139
                  ++++e  +lr++l+tl+++l++p+q++gr+ el  +
  EFC37759.1 272 IGIRNEDISLRNKLNTLQRELHKPNQFRGRLIELSPQ 308
                 *******************************999765 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.9
                 HHHHHHHHHHH CS
       Nup54 111 elrarletlea 121
                  l + l  l++
  EFC37759.1 343 GLNELLSILKK 353
                 22222222222 PP

>> Nup54_C  Nup54 C-terminal interacting domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       4.2   8.4e+03       9      21 ..     201     213 ..     197     216 .. 0.74
   2 !   24.5   0.7   9.1e-09   1.8e-05       4      39 .]     326     361 ..     324     361 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 4.2
     Nup54_C   9 eeIKQfLkqqQeG 21 
                 +++K     qQ+ 
  EFC37759.1 201 KDVKDRVEKQQKR 213
                 6888888899975 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 9.1e-09
     Nup54_C   4 dadlqeeIKQfLkqqQeGlkhLIeIIkdDlsdLklI 39 
                 d + +e +K fL qq +Gl  L +I k+D +d+  I
  EFC37759.1 326 DDETKENVKNFLEQQTNGLNELLSILKKDIKDINYI 361
                 778899***************************887 PP

>> Nucleoporin_FG2  Nucleoporin FG repeated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6  28.0     7e-08   0.00014       2      96 ..      18     119 ..       3     139 .. 0.75
   2 ?   -2.2   0.2      0.54   1.1e+03     316     368 ..     273     322 ..     250     332 .. 0.72

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 7e-08
  Nucleoporin_FG2   2 GfnfGsgalgst..ttgggfslGaaaa.anaasagGlsfGtllaaaaapas.ttttaslglG.....gglfaqkpatGfslgtpasgaaaaaat 86 
                      GfnfG+++ + t   t++gf +Ga ++ an+  ++G+ fGt+ + ++ p++ tt ++   +G     ++  + +p+tGf +gt+++ a +   t
       EFC37759.1  18 GFNFGTTNNTGTtgGTSTGFNFGAPTTtANTQPTTGFNFGTTNTQPTQPTTgTTGSTGFNFGttgtaTNTQPTQPTTGFNFGTTNTVANT--NT 109
                      9****99655551456789****9655499999*********99999987656655554444111114556678999****999987776..89 PP

  Nucleoporin_FG2  87 gltlgapaat 96 
                      g+ lg+p+  
       EFC37759.1 110 GFNLGTPTNN 119
                      9999999765 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.54
  Nucleoporin_FG2 316 elknadialrtqktppGlqhentapadyfrslveqfevqlqqyrqqieelenh 368
                       ++n di+lr +     lq e   p ++ r+ + ++  q++ y qq + l n 
       EFC37759.1 273 GIRNEDISLRNKL--NTLQRELHKPNQF-RGRLIELSPQVNYYLQQSNLLLNN 322
                      4789999999765..5799999999875.555555788999999998877665 PP

>> Parvo_coat_N  Parvovirus coat protein VP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   0.00019      0.39      14      59 ..     112     158 ..     101     162 .. 0.83
   2 ?   -3.0   0.1       4.2   8.4e+03      45      60 ..     320     335 ..     315     338 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00019
  Parvo_coat_N  14 daGePvn.eaDaAAreHDkaYdqllksGknPYlkfnaaDqelldelK 59 
                   + G P+n + D   ++ + +Y    +  +nPY kf +   +++d+ K
    EFC37759.1 112 NLGTPTNnPIDNSFKIIELKYKSSTDTPDNPYCKFIHFFYNVVDDGK 158
                   5689986268*************************988777777666 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.2
  Parvo_coat_N  45 lkfnaaDqelldelKd 60 
                   l  n+ D+e  +++K+
    EFC37759.1 320 LNNNTLDDETKENVKN 335
                   5567778888888886 PP

>> Spectrin  Spectrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.1   0.00097       1.9       9      66 ..     216     273 ..     208     280 .. 0.90
   2 ?    3.6   1.1     0.047        93      30      94 ..     282     346 ..     274     357 .. 0.75
   3 ?    1.0   1.0       0.3     6e+02      30      70 ..     327     369 ..     312     374 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00097
                 HHHHHHHHHHHHHHHHCCSSCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Spectrin   9 dadeleeWieekeellssedlgkdleevqallkkhkaleaelaaqqervkalnelaek 66 
                  ++++++ ++ k  + +++  + +++ +    ++h++l + +   q +++ l++ +  
  EFC37759.1 216 LMNDFLKVLDSKISECKTKHEADTMSRIGGIKQRHTDLSHRILKIQSKLEVLTQSGIG 273
                 699*************9999********************************998765 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.047
                 SSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHTTHHHHHHHHHHHHHHHHHHHH CS
    Spectrin  30 gkdleevqallkkhkaleaelaaqqervkalnelaeklldeghsaseeieerleelnerWeeLke 94 
                  ++l+++q+ l+k  +++  l +  ++v+   ++++ ll+++  + e  e+  + l+++   L e
  EFC37759.1 282 RNKLNTLQRELHKPNQFRGRLIELSPQVNYYLQQSNLLLNNNTLDDETKENVKNFLEQQTNGLNE 346
                 689999********************************998855444444444444444444444 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.3
                 SSSHHHHHHHHH.HHHHHHHHHHHHHHHHHHHHHHHHHH.HHT CS
    Spectrin  30 gkdleevqallk.khkaleaelaaqqervkalnelaekl.lde 70 
                  ++ e+v++ l+ +  +l + l+  ++ +k++n +++++ +d+
  EFC37759.1 327 DETKENVKNFLEqQTNGLNELLSILKKDIKDINYIKQQVsADK 369
                 55667788877757788888888899******99999994444 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   3.4   0.00031      0.62      14      96 ..     203     297 ..     198     343 .. 0.89
   2 ?   -0.7   0.5      0.98     2e+03      54      61 ..     335     342 ..     305     373 .. 0.46

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00031
      APG6_N  14 ldkqleqaekerdaYeeflkklkkekkeeek............qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealee 96 
                 ++ ++e+++k ++ +++flk l+++ +e ++             ++ + +l +++ k++++ e l +    + +e+ +l+++l++l++el + ++
  EFC37759.1 203 VKDRVEKQQKRIELMNDFLKVLDSKISECKTkheadtmsriggIKQRHTDLSHRILKIQSKLEVLTQSGIGIRNEDISLRNKLNTLQRELHKPNQ 297
                 68899******************9977765589999999999999999999999***********************************987665 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.98
      APG6_N  54 eeleklek 61 
                 + le+  +
  EFC37759.1 335 NFLEQQTN 342
                 11222111 PP

>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.4     3e-05     0.059     222     290 ..     201     269 ..     185     277 .. 0.94
   2 ?   -2.3   0.7       1.1   2.2e+03     224     240 ..     281     297 ..     279     370 .. 0.46

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3e-05
       FAM76 222 tqLkeeiaslkkqleqkdqellekdkkitelkaellekekelreklkelekeakekieklekkirellk 290
                 +++k+++++ +k++e  +  l   d ki+e k++++    +    +k+++ + +++i k+++k + l++
  EFC37759.1 201 KDVKDRVEKQQKRIELMNDFLKVLDSKISECKTKHEADTMSRIGGIKQRHTDLSHRILKIQSKLEVLTQ 269
                 789***********************************999999******************9988865 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.1
       FAM76 224 Lkeeiaslkkqleqkdq 240
                 L++++++l+++l++ +q
  EFC37759.1 281 LRNKLNTLQRELHKPNQ 297
                 55566666666655444 PP

>> Syntaxin-6_N  Syntaxin 6, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.4     0.032        64       3      84 ..     200     282 ..     199     298 .. 0.56
   2 ?    6.1   1.0    0.0081        16      22      76 ..     321     374 ..     303     376 .] 0.78

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.032
  Syntaxin-6_N   3 FfevkeeVqkslnkaeslyrrwerlledtssstseeldetrteLrkalrsiewdledLeetvrivek.....npskfkidekelsrr 84 
                   F +vk+ V+k+ +++e l++ + ++l++++   se   +++ +  + ++ i++   dL + +  +++      +s  +i+++++s r
    EFC37759.1 200 FKDVKDRVEKQQKRIE-LMNDFLKVLDSKI---SECKTKHEADTMSRIGGIKQRHTDLSHRILKIQSklevlTQSGIGIRNEDISLR 282
                   6677777777766664.5556655555554...444445555555666666666666666664333323332224455555555555 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0081
  Syntaxin-6_N  22 rrwerlledtssstseeldetrteLrkalrsiewdledLeetvriveknpskfki 76 
                   ++ + l ++t+++ ++ l+++++ L++ l+ +++d++d++   + v+++++k +i
    EFC37759.1 321 NN-NTLDDETKENVKNFLEQQTNGLNELLSILKKDIKDINYIKQQVSADKQKRSI 374
                   33.45666777778999**********************9999999998888665 PP

>> Carbpep_Y_N  Carboxypeptidase Y pro-peptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.1      0.62   1.2e+03      43      73 ..     201     231 ..     196     237 .. 0.80
   2 ?    5.9   3.6    0.0089        18      31      80 ..     314     358 ..     262     360 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.62
  Carbpep_Y_N  43 kklsklleeeekknnvfekiskvlneplkel 73 
                  k+ +  +e+++k  +++++  kvl+ +++e 
   EFC37759.1 201 KDVKDRVEKQQKRIELMNDFLKVLDSKISEC 231
                  6777888889999999999999999988876 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0089
  Carbpep_Y_N  31 Qqalklelnydtkklskllee..eekknnvfekiskvlneplkeltseakki 80 
                  Qq   l ln++      +l++  +e+++n++e+ ++ lne+l+ l++++k+i
   EFC37759.1 314 QQSNLL-LNNN------TLDDetKENVKNFLEQQTNGLNELLSILKKDIKDI 358
                  444333.4444......34333478889*********************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1387  (0.0773607); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.72u 0.34s 00:00:01.06 Elapsed: 00:00:00.53
# Mc/sec: 2151.82
//
Query:       EFC37760.1  [L=189]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       651  (0.0363099); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1212.24
//
Query:       EFC37761.1  [L=275]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.3e-10   39.3   2.2      1e-09   38.1   2.2    1.6  1  G-patch         G-patch domain
    0.00069   19.7   0.3    0.00069   19.7   0.3    4.1  3  G-patch_2       G-patch domain
     0.0085   16.2  50.9      0.014   15.5  50.9    1.4  1  YL1             YL1 nuclear protein
  ------ inclusion threshold ------
      0.015   13.8  52.1      0.022   13.3  52.1    1.2  1  Mpp10           Mpp10 protein
        1.8    7.0  36.0        2.3    6.7  36.0    1.2  1  LRIF1           Ligand-dependent nuclear receptor-interacting
        2.9    6.6  40.1        4.3    6.1  40.1    1.3  1  Mitofilin       Mitochondrial inner membrane protein


Domain annotation for each model (and alignments):
>> G-patch  G-patch domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.1   2.2   3.5e-13     1e-09       2      44 ..      34      76 ..      34      77 .. 0.97

  Alignments for each domain:
  == domain 1  score: 38.1 bits;  conditional E-value: 3.5e-13
     G-patch  2 sniGvkmLqkmGWkpGqGLGkkeqGiaePieakikkdraGlGa 44
                s++G+k+L k+G+  G+GLGk+++Gi++++ + +k+ ++G+G+
  EFC37761.1 34 SGFGMKILGKYGFQAGEGLGKNKDGIKDHVTTSKKYHQTGIGI 76
                699*************************************995 PP

>> G-patch_2  G-patch domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.3   2.3e-07   0.00069      15      57 ..      34      76 ..      30      80 .. 0.88
   2 ?  -16.9  22.2         6   1.8e+04      47      47 ..     141     141 ..     111     172 .. 0.58
   3 ?   -3.8   0.1       4.9   1.4e+04      33      36 ..     182     185 ..     174     193 .. 0.44

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 2.3e-07
   G-patch_2 15 eeFGaAlLrGMGWkegqgigknkkgrvkpeepkrRpgrlGLGa 57
                + FG+ +L  +G+++g+g gknk g ++ +   ++ ++ G+G 
  EFC37761.1 34 SGFGMKILGKYGFQAGEGLGKNKDGIKDHVTTSKKYHQTGIGI 76
                68**********************9988888888888999997 PP

  == domain 2  score: -16.9 bits;  conditional E-value: 6
   G-patch_2  47 k 47 
                 k
  EFC37761.1 141 K 141
                 0 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 4.9
   G-patch_2  33 igkn 36 
                 ++k+
  EFC37761.1 182 EEKT 185
                 1222 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5  50.9   4.8e-06     0.014      48     228 ..     105     267 ..      59     273 .. 0.42

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 4.8e-06
                 xxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxx RF
         YL1  48 nsDsdfdsdeedee.sdeeedeeegekelerqerkkrkkekkkrkaqkkkskkkkkkqkkkkkkkidpqakeprpkkks.eraswlpaeslltpkrRks 144
                  sDsd +sd++dee ++++e++e++ek   ++e+k++    k++k   + s++k++k+kk+kk+     +ke++ kk+s e++s ++++s+ ++k  k+
  EFC37761.1 105 TSDSDSSSDSSDEEeKKKKEKKEKKEK---KKEKKEK----KEKK---EESEEKSDKKKKEKKE-----KKEKKSKKRSkEDSSDSDSNSSNEEKTSKK 188
                 344444444433331122222222222...1222222....1111...1111111111111111.....111222333323333344433333334566 PP

                 xxxxxxxxxxxxxxxxxxx.xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1 145 sRastvenkeqleerlker.eerrkkile.rmrkkaarkkkkkkerplTQeerLaeAke.tEeeNlksLnryeeqEeekkkeqrakl 228
                 ++  tve ++ l+ +  ++ e r  ++++ r++ k+ r  kk++ ++l    +L+eAke +   N +  ++++    ek+k q++k 
  EFC37761.1 189 TKHCTVEGSSVLQPEFFKEcEGR--TLKKyRQEGKESR-AKKHE-DEL--IAKLKEAKEkMDAFNQQ--RKFKHVVTEKRKVQQNKV 267
                 66667777777776666654666..2222122222222.22222.222..34555554313444444..445555445554455444 PP

>> Mpp10  Mpp10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3  52.1   7.3e-06     0.022      69     219 ..      90     251 ..      85     275 .] 0.59

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 7.3e-06
       Mpp10  69 avleellkkiskllakkeklklldeeeeeeseeseeeeeeee.eeeeeeeeeeeeeeeeeeekeeseekeeeeesekeeeeededeeeeieeeekkskk 166
                 + ++++l++i+k ++ +++ ++ d+++eee++++e++e++e+ +e++e++e++ee+ee++++k++++++++e++s+k ++e+++d++++ ++eek+skk
  EFC37761.1  90 NSYNQMLDNIAKKKSTSDSDSSSDSSDEEEKKKKEKKEKKEKkKEKKEKKEKKEESEEKSDKKKKEKKEKKEKKSKKRSKEDSSDSDSNSSNEEKTSKK 188
                 556677777777777777777777777776666444444444155555555555555556677777777888889999999999999999999999999 PP

       Mpp10 167 kkk.kkkkksvvddkFFkldemekflekeekkeerkk...........eeeeddeeidyfedlss 219
                 +k+ + + +sv   +FFk  e    + k+ ++e +++           + +e +e++d f+++ +
  EFC37761.1 189 TKHcTVEGSSVLQPEFFKECEG--RTLKKYRQEGKESrakkhedeliaKLKEAKEKMDAFNQQRK 251
                 777567778888*****97663..33333333333222112344555555555555555554444 PP

>> LRIF1  Ligand-dependent nuclear receptor-interacting factor 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7  36.0   0.00076       2.3     550     703 ..      95     248 ..      60     256 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00076
       LRIF1 550 yLtripltsssekp.erlaspssleksesskeaevvvkltkeieeekkkikleqdlskKRkaktsklvdsaKrrktsnksstssnsetsspssqllsss 647
                 +L  i  ++s+  +  + +s+++ ek+++  + e   k+++++e+++kk+++e++++kK+k k+ k++ ++K+r  + +s++ sns ++  +s+  +  
  EFC37761.1  95 MLDNIAKKKSTSDSdSSSDSSDEEEKKKKE-KKEKKEKKKEKKEKKEKKEESEEKSDKKKKEKKEKKEKKSKKRSKEDSSDSDSNSSNEEKTSKKTKHC 192
                 577787777777662333333333333333.344445557788889999************************97777777777766666667666666 PP

       LRIF1 648 lsksavslqasistdsskssqekksEeellsqesdeketlssvlvsseedeslfee 703
                 +++    lq +   ++   + +k   e + s+ ++++++l++ l  ++e+ + f++
  EFC37761.1 193 TVEGSSVLQPEFFKECEGRTLKKYRQEGKESRAKKHEDELIAKLKEAKEKMDAFNQ 248
                 66666666999999988888888888888888899999999988888888887775 PP

>> Mitofilin  Mitochondrial inner membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1  40.1    0.0014       4.3      59     214 ..      86     244 ..      41     272 .. 0.58

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0014
   Mitofilin  59 e........klkeisklqvsavsevtkeskepkeekkkeksekqssassevaeeeaeatkkaaeakaqqpkseqekekaleevlkealskaekataaak 149
                           l++i k+++++ s + ++s++ +e+kkkek+ek+++++++++++e+++++++++ k++++k+e++ +k+++ ++++ +    +   + +
  EFC37761.1  86 YwwensynqMLDNIAKKKSTSDSDSSSDSSDEEEKKKKEKKEKKEKKKEKKEKKEKKEESEEKSDKKKKEKKEKKEKKSKKRSKEDSS-DSDSNSSNEE 183
                 1555555557889999999999999999988888888888877777777777777777777777775555554444444444433333.3333333334 PP

   Mitofilin 150 eakdeakkavkeavdklkeasdteeksrekardtaleaaeaaaek.......eleklkevielakqseeeaa 214
                 +  +++k+ + e ++ l+ ++ +e ++r+ ++      +e +a+k       +          +k+++e+ +
  EFC37761.1 184 KTSKKTKHCTVEGSSVLQPEFFKECEGRTLKKYRQEG-KESRAKKhedeliaK----------LKEAKEKMD 244
                 4444566666666666666666666666655543222.333332223333332..........322222221 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4054  (0.226114); expected 358.6 (0.02)
Passed bias filter:                      963  (0.0537119); expected 358.6 (0.02)
Passed Vit filter:                       641  (0.0357521); expected 17.9 (0.001)
Passed Fwd filter:                       191  (0.0106531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 2.01u 0.37s 00:00:02.38 Elapsed: 00:00:00.63
# Mc/sec: 1305.98
//
Query:       EFC37762.1  [L=138]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.9e-08   32.5   0.0    1.5e-07   31.6   0.0    1.4  2  Lysine_decarbox  Possible lysine decarboxylase
     0.0046   16.6   0.0     0.0054   16.3   0.0    1.2  1  LDcluster4       SLOG cluster4 family
  ------ inclusion threshold ------
      0.091   12.9   0.1        0.2   11.8   0.1    1.7  1  YmzC             YmzC-like protein


Domain annotation for each model (and alignments):
>> Lysine_decarbox  Possible lysine decarboxylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.6   0.0   2.5e-11   1.5e-07       1      81 [.       1      83 [.       1      99 [. 0.90
   2 ?   -2.4   0.0      0.77   4.6e+03      95     105 ..     118     128 ..     104     132 .. 0.69

  Alignments for each domain:
  == domain 1  score: 31.6 bits;  conditional E-value: 2.5e-11
                     HHHHHHHHHHTTS-EEEEEECCHHH..HHCCTTT-SEEEEESSHHHHHHHHHHHESEEEE-S-SHHHHHHHHHHHHHHHTTSS CS
  Lysine_decarbox  1 meavakgaleaggrviGiipkilla..eeapneevnelvivedmeeRkealveladafvilPGGiGTleElleiltliqlgkh 81
                     me v+kga+ +   v G+i +++     e+ n++++++  ++d+  R + l + +  +v+lPG +GT+ El+ ++ l ++++h
       EFC37762.1  1 MEGVSKGAASHPVDVKGVISSKTFYkrTEQGNKYLTTTQDTNDLYGRIKGLTDSGSYIVVLPGSLGTAAELMIAWNLYYINEH 83
                     999****************998887445666***********************************************99999 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.77
                      CHHHHHHHHHH CS
  Lysine_decarbox  95 ydkllefletl 105
                      ++k+++f+ t 
       EFC37762.1 118 WEKIIKFISTE 128
                      78999999765 PP

>> LDcluster4  SLOG cluster4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   9.1e-07    0.0054      45     118 ..       1      76 [.       1      97 [. 0.77

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 9.1e-07
  LDcluster4  45 meaaskGakeagGltvGilpassekehsnk...yvdiiiyTGlglagRnlilvlssdvviaiggrsGTlsEialale 118
                 me +skGa ++   + G++ +++  + +++   y++    T  +l gR   l+ s   +++++g+ GT+ E+++a++
  EFC37762.1   1 MEGVSKGAASHPVDVKGVISSKTFYKRTEQgnkYLTTTQDT-NDLYGRIKGLTDSGSYIVVLPGSLGTAAELMIAWN 76 
                 67778888888777888888765555555411144444444.5666799**************************86 PP

>> YmzC  YmzC-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   3.3e-05       0.2      23      52 ..      79     108 ..      51     111 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.3e-05
                 -STTEEEEEETTEEEEEEEETTTTEEEEEE CS
        YmzC  23 legnHfavvkDdeikiykfdedenEvkLiK 52 
                   ++Hf + +D   ki+ f  +  E+kL K
  EFC37762.1  79 YINEHFPATEDPVKKIFVFRGKDIELKLGK 108
                 5699************************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (138 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       333  (0.0185733); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 881.24
//
Query:       EFC37763.1  [L=127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.7e-07   29.8   0.0    9.7e-07   29.3   0.0    1.2  1  DNA_ligase_A_C  ATP dependent DNA ligase C terminal region


Domain annotation for each model (and alignments):
>> DNA_ligase_A_C  ATP dependent DNA ligase C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.0   5.4e-11   9.7e-07       3      64 ..      54     117 ..      52     122 .. 0.87

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 5.4e-11
                     GSEEEEEEEEEE..TTEEEEEEEE-SS--HHHHHHHHHHHGGGEECTTCESS---HHHHTTEEE CS
  DNA_ligase_A_C   3 glvgslllgvyd..dgkleyvgkvgtGfsdaeleelrkklkelerkkppfaekvpeeekrdvWv 64 
                     + ++ + +++yd   gk+++v+  + Gf+++  +e+ ++l++l   +p+ +   +e++ ++vW+
      EFC37763.1  54 NNFTRFQMACYDksCGKFVTVCSLSVGFTQELKQEISERLSKLIIPSPSANVIFNEKQPAQVWF 117
                     67899*******99999************************99999999866666665556997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       731  (0.0407719); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 805.20
//
Query:       EFC37764.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-14   54.5   0.0    2.3e-14   53.9   0.0    1.3  1  APH       Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.076   13.2   0.1       0.13   12.5   0.1    1.4  1  HmuY      HmuY protein


Domain annotation for each model (and alignments):
>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.9   0.0   2.6e-18   2.3e-14       9     223 ..      33     302 ..      26     317 .. 0.67

  Alignments for each domain:
  == domain 1  score: 53.9 bits;  conditional E-value: 2.6e-18
                 SSCEEEEEEETT.--EEEEEE-TT.S-HHHHHHHHHHHHHHHHTT-...B........................--B-CTTBS-EEETTE......... CS
         APH   9 asnrtylvttpa.gryvlrrnppa.raaeeirrevallrlLakagv...p........................vPevlagdtddeeigl......... 69 
                  +n+tylv++ + ++y+lr+ p+  r+  +i +e+++l l++++ +   +                        +                        
  EFC37764.1  33 SENHTYLVKDNSeQSYILRLTPKHhRSVKSIWAELEYLNLIHDQAKlhsQdekyalnvcppiakkvnengefllI--------------Aeleepyetd 117
                 79**********99**********9*****************776666515566666444444444443333333..............0444445555 PP

                 .....EEEEEE----EE-SSHHHHHHHHHHHHHHHHHHCCHHCH.............-STTTB-SHHCHTCCHHHHHHCHHHCCCGCCTCCHHHHHHHH CS
         APH  70 .....lfalieyvpgrsllrklsaaqlpellealgeflaalhqv...........d.paalpladflaqdlellrqlesatarllaselldlleeleeq 151
                      + +l+ey  g s+ +k     ++ ++ a+g++ ++lh +           d +a+  ++  + ++ +++  + +++a+++++  + l++  +++
  EFC37764.1 118 kekvwYGVLFEYAQGNSVVDKWIGLTDDSMIVAIGDAMGRLHKIisekagnperwDeMAKYIPEISGTHNGACDLNRIRERAQKDHEISKTLIQIYDAE 216
                 5554499***********99444557899999************4433333333322333333333335555555555554444444444444444444 PP

                 HHHHHHHH--SSS-EEEE-SS-SGGGEEEC....TTEEEEE---TT-EEEECCHHHHCCHHHCSCHCC...............CHCHHH CS
         APH 152 vlaalaallpgelptvllHgDlhpgNllvd..pddgrvtGviDfedaglgpplyDlavllrswtseld...............peflaa 223
                 +++ l+ +   ++  +++HgD++  N   +  p+++++  ++Df+ ++     ++l+v+l + t +++               ++f++ 
  EFC37764.1 217 LAEFLKSHPIDSENYGIVHGDINVSNYFAKvqPEGTKL-WIFDFDQVHNNYFGHELGVVL-H-TVTFFendglgigkiegfdgDRFREL 302
                 55555555555*********************999999.9********************.6.45666334455555555555555555 PP

>> HmuY  HmuY protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   1.4e-05      0.13      86     138 ..       9      56 ..       1      69 [. 0.74

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.4e-05
                 .EEEE-TTCCGGE.....S-EEEE--......-EEEEE-TTS-EEEEEEEECC CS
        HmuY  86 tktdvnpilsswltegskpptyalsnasikknrvfvlkdkdGnyaklrftdyt 138
                 +++++n+i + w  e+s     + +  ++++n+++++kd++++ + lr+t   
  EFC37764.1   9 SQNSINTINKLWGFESS-----TQTVIKQSENHTYLVKDNSEQSYILRLTPKH 56 
                 47899999999974433.....456677899*****************99655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       563  (0.0314016); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 2423.38
//
Query:       EFC37765.1  [L=394]
Description: acyl-Coenzyme A dehydrogenase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      8e-43  146.2   0.5    1.1e-42  145.8   0.5    1.2  1  Acyl-CoA_dh_1  Acyl-CoA dehydrogenase, C-terminal domain
    1.8e-25   89.0   0.0      3e-25   88.2   0.0    1.4  1  Acyl-CoA_dh_M  Acyl-CoA dehydrogenase, middle domain
    1.1e-23   84.1   0.0    2.7e-23   82.8   0.0    1.6  1  Acyl-CoA_dh_N  Acyl-CoA dehydrogenase, N-terminal domain
    9.2e-15   55.1   0.0    1.3e-14   54.6   0.0    1.3  1  Acyl-CoA_dh_2  Acyl-CoA dehydrogenase, C-terminal domain


Domain annotation for each model (and alignments):
>> Acyl-CoA_dh_1  Acyl-CoA dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  145.8   0.5   2.5e-46   1.1e-42       1     149 [.     241     389 ..     241     390 .. 0.99

  Alignments for each domain:
  == domain 1  score: 145.8 bits;  conditional E-value: 2.5e-46
                    TBHHHHHTTTT--S-----..-SHHHHHHHHHHHHHHHTSB-CC-BGGGSHHHHHHHHHHHHHHHHHHHHHHHHHH--------HHHHHHHHHHHH CS
  Acyl-CoA_dh_1   1 gkGfrvametlnheRlavaaaalglarraleealeyarrrkafgkplidhqlvreklaemaaeleaarllvyraaealdagkpdraeasmaKlfas 96 
                    gkG ++a+e ln +R+++aa+++gla+ +++ ++ y+++rk+fg+p++d+q +  +  ++a+e+ea rl+vy+aa++ +ag+  ++ea+maK+++s
     EFC37765.1 241 GKGYKIAIEMLNEGRIGIAAQMIGLAQGVFDYTMPYLKSRKQFGTPIADFQMMEYHYSKLATEIEAGRLMVYNAARMKEAGQVFTKEAAMAKFYTS 336
                    79********************************************************************************************** PP

                    HHHHHHHHHHHHHHGGGTTSGGGHHHHHHHHTHHHHHSSS-HHHHHHHHHHHH CS
  Acyl-CoA_dh_1  97 elaqevadlamqllGgaGyleeypverlyrdarvlrigeGtseiqrniiarrl 149
                    e+a +va++++++lGg G+ ++ + e++yrd+ +  i+eGts+i + +ia+++
     EFC37765.1 337 EVAGNVATKCIEMLGGVGFCRDFSAEKYYRDCIIGKIYEGTSNINLVTIAKHV 389
                    **************************************************986 PP

>> Acyl-CoA_dh_M  Acyl-CoA dehydrogenase, middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.2   0.0   6.8e-29     3e-25       1      97 []     133     229 ..     133     229 .. 0.94

  Alignments for each domain:
  == domain 1  score: 88.2 bits;  conditional E-value: 6.8e-29
                    EEE---SS-SS-GGG---EEEEETT.EEEEEEEEEEEETTTT-SEEEEEEETS-------EEEEEEE..GGGEEE-----BSS-TTS-EEEEEEE. CS
  Acyl-CoA_dh_M   1 afalTEpqaGsdvasvkttaaerdggeyvlnGeKiwitnaaiatlalvlartekpdrarglslflvprdapgvsvrrieeklGlrglptgelvfed 96 
                    +f+l+E ++Gsd+ s+kt+a  +++g+yvlnG+K+wit++++a++++v+a t+  ++++g++ flv++ +pgv+++++e+klG+r  +t+e+ +ed
     EFC37765.1 133 SFCLSEASSGSDAFSLKTKAELQSDGSYVLNGTKCWITSSQEASFYIVMANTDFSKGYKGITAFLVDKTNPGVKIGKKEDKLGIRASSTCEVILED 228
                    69******************777777*************************666668**************************************9 PP

                    . CS
  Acyl-CoA_dh_M  97 v 97 
                    +
     EFC37765.1 229 C 229
                    7 PP

>> Acyl-CoA_dh_N  Acyl-CoA dehydrogenase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.8   0.0     6e-27   2.7e-23       1     111 [.      17     128 ..      17     129 .. 0.96

  Alignments for each domain:
  == domain 1  score: 82.8 bits;  conditional E-value: 6e-27
                    THHHHHHHHHHHHHHHHHT.HHHHHHHHHHTSGHHHHHHHHHHTTCTSTTS-GGGTS--S-HHHHHHHHHHHHHH-HHHHHHHHHHHHTTHHHHHH CS
  Acyl-CoA_dh_N   1 teeqealrdtvrefaeeel.aphaaewdeegefprelwkklaelGllgitvpeeygGagldyleaaivaeelaradaglalllgvhsslvapailr 95 
                    tee+ ++r  v++f++++l  + + ++d+e + + +l++ l e Gl+gi +pee+gG+g+++++++i++eela++d ++++++ v+++lv + + +
     EFC37765.1  17 TEEEVMMRNLVQDFCKQSLpWELVSKMDKESKLDPKLLDSLFEVGLMGIEIPEEFGGSGANFTSSIIAIEELAKVDPSISVIVDVQNTLVNNLVRN 112
                    79*****************5578999999999999************************************************************* PP

                    HS-HHHHHHHHHHHHT CS
  Acyl-CoA_dh_N  96 fGteeqkrryLpklas 111
                    +G++eq+++yL  la+
     EFC37765.1 113 YGNKEQQEKYLTLLAT 128
                    ***********98875 PP

>> Acyl-CoA_dh_2  Acyl-CoA dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.6   0.0     3e-18   1.3e-14       1     133 [.     256     378 ..     256     379 .. 0.97

  Alignments for each domain:
  == domain 1  score: 54.6 bits;  conditional E-value: 3e-18
                    .HHHHHHHHHHHHHHHHHHHHHHHHHCTTT-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHHHHHHHH CS
  Acyl-CoA_dh_2   1 lgiaavalGaAraalaefvelarervrassgekladdpatqlalaeaaarldAAralleraaaraealaaagkevtvedraearraaalavelaia 96 
                    +giaa+++G+A+++++ ++ + + r++  +g+++ad++++++   ++a++++A r+++++aa+      +ag+ +    ++ea++a+ +++e a +
     EFC37765.1 256 IGIAAQMIGLAQGVFDYTMPYLKSRKQ--FGTPIADFQMMEYHYSKLATEIEAGRLMVYNAARM----KEAGQVF----TKEAAMAKFYTSEVAGN 341
                    589************************..********************************999....8999998....99*************** PP

                    HHHHHHHHCGGGGGBTT-HHHHHHHHHHHHCTSGGG- CS
  Acyl-CoA_dh_2  97 avdalfeaaGgsalrkesplqRlwRDahaaaaHaaln 133
                    ++ +++e+ Gg +   +   + ++RD  +++++++++
     EFC37765.1 342 VATKCIEMLGGVGFCRDFSAEKYYRDCIIGKIYEGTS 378
                    ********************************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       502  (0.0279993); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2277.00
//
Query:       EFC37766.1  [L=206]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (206 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       753  (0.041999); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1269.66
//
Query:       EFC37767.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.3e-06   27.0   0.7     0.0026   17.5   0.1    2.1  2  Glyco_transf_34  galactosyl transferase GMA12/MNN10 family
     0.0032   17.5   0.0     0.0051   16.8   0.0    1.3  1  Nucleotid_trans  Nucleotide-diphospho-sugar transferase


Domain annotation for each model (and alignments):
>> Glyco_transf_34  galactosyl transferase GMA12/MNN10 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.1   2.9e-07    0.0026      34     108 ..     121     197 ..      97     213 .. 0.81
   2 !    8.6   0.1   0.00016       1.4     144     188 ..     212     258 ..     195     263 .. 0.78

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 2.9e-07
  Glyco_transf_34  34 vdYaekhgyeifykkvsalla.eemnsvWaklpairaamkky.PeaewiWwlDqdAlimnmdlsleehvlkperLee 108
                        Ya++hgy  ++  +++  +    +++W kl +i + + +   + +++ ++D+d  +  m+ ++e  +++   +++
       EFC37767.1 121 QRYAKRHGYPYEFIIAEENGRnVTRHAAWYKLKLIERYLIENeKKCQFVLFIDSDCYFRIMSATIESEIIDLYDMNQ 197
                      46******99888666666664567788*******99887762579***********************98877776 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00016
  Glyco_transf_34 144 g..lnagsflirnsewsklllDlwadpllrekkkavtesdeqsaley 188
                      g  ln+g +++rn+  s ++l  w+d   ++ +  + +  eq++le 
       EFC37767.1 212 GdfLNSGTLFFRNNVQSIRFLREWWDEGEKSPQYFFSHPWEQKILEI 258
                      3349*********************9999888888778888888875 PP

>> Nucleotid_trans  Nucleotide-diphospho-sugar transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   5.7e-07    0.0051      90     148 ..     182     256 ..     165     277 .. 0.69

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 5.7e-07
  Nucleotid_trans  90 daDvlvss.Dsldgttadelknli............NsGfffvrateatkallkkwaeelasesglw.....Dqdvf 148
                      +a +++   D +d ++ ++ k  +            NsG+ f+r++ +++++l++w +e +++++       +q+++
       EFC37767.1 182 SATIESEIiDLYDMNQENGTK--FflapkdeygdflNSGTLFFRNNVQSIRFLREWWDEGEKSPQYFfshpwEQKIL 256
                      444444444444433333333..2346667777777********************999998866334555566655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       643  (0.0358637); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.23s 00:00:00.63 Elapsed: 00:00:00.37
# Mc/sec: 2649.63
//
Query:       EFC37768.1  [L=294]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-12   48.0   0.5    2.1e-12   47.1   0.5    1.5  1  MMR_HSR1      50S ribosome-binding GTPase
    2.6e-09   36.7   1.7    2.6e-09   36.7   1.7    1.7  2  AIG1          AIG1 family
      1e-05   25.5   2.2    7.5e-05   22.7   0.3    2.5  2  RsgA_GTPase   RsgA GTPase
    1.5e-05   24.6   0.5    3.2e-05   23.5   0.5    1.5  1  FeoB_N        Ferrous iron transport protein B
    0.00016   21.8   1.4      0.025   14.6   0.3    2.5  2  Dynamin_N     Dynamin family
     0.0018   18.5   0.8      0.013   15.8   0.3    2.6  2  Roc           Ras of Complex, Roc, domain of DAPkinase
     0.0019   17.8   0.5     0.0085   15.7   0.2    2.2  1  Ras           Ras family
     0.0031   17.9   0.0     0.0079   16.6   0.0    1.7  1  RNA_helicase  RNA helicase
     0.0035   17.8   0.1     0.0061   17.1   0.1    1.5  1  ABC_tran      ABC transporter
     0.0035   17.0   0.3     0.0094   15.7   0.0    1.8  2  AAA_29        P-loop containing region of AAA domain
  ------ inclusion threshold ------
       0.01   16.3   1.0      0.049   14.1   0.3    2.5  2  AAA           ATPase family associated with various cellular 
      0.013   14.9   0.2      0.033   13.5   0.1    1.6  1  Gtr1_RagA     Gtr1/RagA G protein conserved region
      0.019   15.4   0.0      0.042   14.2   0.0    1.6  1  AAA_16        AAA ATPase domain
      0.019   14.7   0.8      0.041   13.6   0.8    1.6  1  AAA_24        AAA domain
      0.036   14.3   0.0       0.06   13.6   0.0    1.3  1  AAA_28        AAA domain
      0.037   14.3   0.1       0.13   12.6   0.0    2.1  2  AAA_22        AAA domain
      0.038   13.3   0.7      0.068   12.4   0.1    1.8  2  Septin        Septin
      0.043   13.0   0.1      0.043   13.0   0.1    2.2  3  DUF815        Protein of unknown function (DUF815)
      0.047   13.2   0.0        0.1   12.1   0.0    1.6  1  AAA_7         P-loop containing dynein motor region
       0.12   12.9   0.2       0.45   11.1   0.2    2.2  1  AAA_18        AAA domain


Domain annotation for each model (and alignments):
>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.1   0.5   2.4e-15   2.1e-12       1     114 []       4     129 ..       4     129 .. 0.68

  Alignments for each domain:
  == domain 1  score: 47.1 bits;  conditional E-value: 2.4e-15
                 EEEEEESTTSSHHHHHHHHHTSTEEE.SSSTTSSSSEEEEEEEETT.EEEEEEECGGCSS.....HHHHHH.HHHHHHHHHHCT..SEEEEEEETTTTC CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaiv.sdkpgtTrdinegrvklkg.keielvDtpGlie.....gaseek.glgkaflaleea..dlillvvdaseek 89 
                 +v+i+G++ vGKS++inal ++k  v     gtT + +e  +k +  +ei l+Dt+Gl e     ++s +     k++l++  +  +l+++v   + + 
  EFC37768.1   4 RVLIFGQSGVGKSSMINALANSKLPVlDGAVGTTFESEEVSFKDSSnQEILLIDTVGLSEsatgtSSSIDSfIKLKNLLKKSTCgfNLMIFVTT-K-DR 100
                 699*******************988846677***********9444499********7554443323333333333344344443377888886.4.44 PP

                 SHHHHHHHHHHHHH....TTSEEEEEEES CS
    MMR_HSR1  90 lkpldeeleellee....akkplilvlnk 114
                 ++ +d+   el +     +k p+i+v+nk
  EFC37768.1 101 ITGNDKANIELFKTilgdDKVPVIMVVNK 129
                 5555544333332334449999*****98 PP

>> AIG1  AIG1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.7   1.7   2.9e-12   2.6e-09       2     133 ..       4     137 ..       3     159 .. 0.82
   2 ?   -1.3   0.0       1.3   1.2e+03      94     128 ..     204     239 ..     182     266 .. 0.62

  Alignments for each domain:
  == domain 1  score: 36.7 bits;  conditional E-value: 2.9e-12
                 EEEEESSTTSSHHHHHHHHHTS--SS--TTTS---SS-EEEEE.EETTEEEEEEE--SCCCTTCCHHCHHHHHH...HHHHHCTT-ESEEEEEEETTB- CS
        AIG1   2 tivlvGktgnGkSaTgNsilgkkaFesklsaqsvtkkcqkksr.twdgkkinViDTPglfdlsvsadkiskeiv...rclllseegihalllvlslgrf 96 
                 ++++ G++g+GkS+ +N++ ++k       a + t +++++s    ++++i  iDT gl ++ + +++ + + +   + l+ s  g + +++v+  +r+
  EFC37768.1   4 RVLIFGQSGVGKSSMINALANSKLPVLD-GAVGTTFESEEVSFkDSSNQEILLIDTVGLSESATGTSSSIDSFIklkNLLKKSTCGFNLMIFVTTKDRI 101
                 899****************999998888.5888899999999879999************9998655555544401155666777999*********** PP

                 SHHHHHHHHHHHHHHCGGGGGGEEEEEEEGGGGTTCC CS
        AIG1  97 teedekalktlkelFGekilkylivvftrkddledds 133
                 t +d++ ++  k++ G++ +  +i+v  + ++led +
  EFC37768.1 102 TGNDKANIELFKTILGDDKVP-VIMVVNKSENLEDCE 137
                 *****************9886.677778888888876 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.3
                 TB-SHHH.HHHHHHHHHHHCGGGGGGEEEEEEEGGG CS
        AIG1  94 grfteed.ekalktlkelFGekilkylivvftrkdd 128
                 +++++++   +++  ++lF + +  +  ++f  ++ 
  EFC37768.1 204 NKYSSKEsVVLIRSSQDLFSKLVRMWNLFLFKTGET 239
                 244443304445667777777777777777766665 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.3   8.4e-08   7.5e-05     101     122 ..       4      25 ..       1      66 [. 0.76
   2 ?    2.1   0.1      0.18   1.6e+02      35      63 ..     109     137 ..      72     162 .. 0.65

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 8.4e-08
                  EEEEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase 101 tsvlvGqSGvGKStLinallpe 122
                   +++ GqSGvGKS++inal+++
   EFC37768.1   4 RVLIFGQSGVGKSSMINALANS 25 
                  57899**************987 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.18
                  HHHHHHHHHHTT-EEEEEEE-GGG--HHH CS
  RsgA_GTPase  35 ldrfLvlaeekgiepvivlnKiDlleeee 63 
                  ++ f +++ + ++++++v+nK + le+ e
   EFC37768.1 109 IELFKTILGDDKVPVIMVVNKSENLEDCE 137
                  44444555667778888888887777766 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.5   3.6e-08   3.2e-05       2     120 ..       4     135 ..       3     147 .. 0.76

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 3.6e-08
                 EEEEEESTTSSHHHHHHHHHTTSEEEEE.STTSSSEEEEEEEEETT.EEEEEEE----SSS...SSSSHHHHHHHHHHHCTS...SSEEEEEEEGGGH. CS
      FeoB_N   2 tvalvGnpnvGkttlfnaltgakqkvgN.wpGvtvekkegklklkg.keveivDlPGiYsl...sayseeekvardflleee...pdvvvnvvdatnl. 91 
                 +v + G+  vGk++++nal+++k  v     G+t e +e+++k ++ +e+ ++D  G  +    ++ s++  +  + ll+++   +++++ v    ++ 
  EFC37768.1   4 RVLIFGQSGVGKSSMINALANSKLPVLDgAVGTTFESEEVSFKDSSnQEILLIDTVGLSESatgTSSSIDSFIKLKNLLKKStcgFNLMIFVTTKDRIt 102
                 57899*******************9976257***********9876699********976656678999999999999977633357888887766662 PP

                 ...HHHHHHHHHHH.HTTSSEEEEEETHHHHHH CS
      FeoB_N  92 ...ernLyLtlqll.elgvpvvlalnmideaek 120
                    + n+ L+  +l + +vpv++++n+++++e+
  EFC37768.1 103 gndKANIELFKTILgDDKVPVIMVVNKSENLED 135
                 221456766655542567899999999888876 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.3   2.8e-05     0.025       1      27 [.       5      30 ..       5      39 .. 0.83
   2 ?    5.7   0.0     0.015        14      95     128 ..      45      78 ..      38     130 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.8e-05
                EEEEEBTTTTHHHHHHHHHTS--S--- CS
   Dynamin_N  1 iavvGsqSsGKSSvlnaLlgedilprg 27
                ++++G+   GKSS++naL  ++ lp+ 
  EFC37768.1  5 VLIFGQSGVGKSSMINALANSK-LPVL 30
                689****************999.6754 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.015
                 EEETTS-SEEEEE---B-SSSGTTSHHHHHHHST CS
   Dynamin_N  95 ilsllvkgltlvDlPGldsvnkrdqelvkeyikk 128
                  ++  ++++ l+D+ Gl +++++  + ++++ik 
  EFC37768.1  45 FKDSSNQEILLIDTVGLSESATGTSSSIDSFIKL 78 
                 567789999***************9666665533 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.3   1.4e-05     0.013       1      65 [.       4      60 ..       4     132 .. 0.71
   2 ?   -2.7   0.0       7.5   6.7e+03      99     116 ..     200     217 ..     186     224 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.4e-05
                EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-S CS
         Roc  1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaG 65
                +v++ G+sgvGK+s+++ + ++k  +  +  +g +f ++ev ++k  +n+      ++ + Dt G
  EFC37768.1  4 RVLIFGQSGVGKSSMINALANSKL-PVLDGAVGTTFESEEV-SFKDSSNQ------EILLIDTVG 60
                5899****************9988.5556779999999887.45543332......234455555 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 7.5
                 HHHHHHHCSSS-EEEEEE CS
         Roc  99 lkelkkvagkspvilvgn 116
                 l  ++k+++k+ v+l+ +
  EFC37768.1 200 LAMINKYSSKESVVLIRS 217
                 456677777777777665 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.2   9.5e-06    0.0085       2      61 ..       5      64 ..       4     159 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 9.5e-06
                EEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGGG CS
         Ras  2 lvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievd.gkevkleiwDTAGqeef 61
                +++ G+s+vGK+s+++  +++k +   +  +g  f ++e++++ +++ ++ + DT G  e 
  EFC37768.1  5 VLIFGQSGVGKSSMINALANSKLPV-LDGAVGTTFESEEVSFKdSSNQEILLIDTVGLSES 64
                7899***************999975.689999********9985677899999**996543 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   8.9e-06    0.0079       1      78 [.       5      80 ..       5      89 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 8.9e-06
  RNA_helicase  1 iwlyGpsgeGKStlakeLakallkklklkkkdsvys.rnpeddfwdgYtgqevvvidDfgqvkdee.npsdlaelirlvs 78
                  ++++G+sg+GKS++++ La++ l  l+    + v +  ++e+  ++  ++qe+++id +g +++ + + s +  +i+l +
    EFC37768.1  5 VLIFGQSGVGKSSMINALANSKLPVLD----GAVGTtFESEEVSFKDSSNQEILLIDTVGLSESATgTSSSIDSFIKLKN 80
                  689**************9999886662....3333324566666677778999999999999988877778888888876 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.1   6.8e-06    0.0061      12      42 ..       3      34 ..       1     133 [. 0.79

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 6.8e-06
                SEEEEEESTTSSHHHHHHHHTTSS--.SEEEE CS
                xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxx RF
    ABC_tran 12 ekvaivGenGaGKStLlkllagllkp.teGei 42
                ++v i+G++G GKS+++++la+   p   G +
  EFC37768.1  3 KRVLIFGQSGVGKSSMINALANSKLPvLDGAV 34
                6899*****************98877634444 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0     1e-05    0.0094      25      43 ..       5      23 ..       1      28 [. 0.88
   2 ?   -2.6   0.0       5.3   4.8e+03      30      42 ..      63      75 ..      37      79 .. 0.64

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1e-05
      AAA_29 25 tlltGpsGsGKSTllDAiq 43
                +l+ G+sG+GKS+++ A++
  EFC37768.1  5 VLIFGQSGVGKSSMINALA 23
                89*************9986 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 5.3
      AAA_29 30 psGsGKSTllDAi 42
                +s +G S+ +D++
  EFC37768.1 63 ESATGTSSSIDSF 75
                3455777777765 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.3   5.4e-05     0.049       1      52 [.       5      47 ..       5     136 .. 0.61
   2 ?   -1.0   0.0       2.4   2.2e+03      82     107 ..     195     216 ..     179     229 .. 0.51

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 5.4e-05
                EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHH CS
         AAA  1 vllyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfke 52
                vl++G  G+GK+++++a+a++ + ++l   + + +        ++ +  fk+
  EFC37768.1  5 VLIFGQSGVGKSSMINALANS-KLPVLDGAVGTTF--------ESEEVSFKD 47
                799*****************9.5555544444444........222222333 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.4
                 HHHHHHHHHHHHHHTTTSSSTEEEEE CS
         AAA  82 eervvnqLlteldgvkkkeskvivig 107
                 ++      l++++++++kes v++i 
  EFC37768.1 195 SR---RIVLAMINKYSSKES-VVLIR 216
                 22...333344444444333.55554 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   3.7e-05     0.033       1      61 [.       4      64 ..       4      77 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.7e-05
   Gtr1_RagA  1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeaf 61
                +vL+ G+sg GK+sm + + +  l+     +g+t + e+ +++ ++n ++ l+D  G ++ 
  EFC37768.1  4 RVLIFGQSGVGKSSMINALANSKLPVLDGAVGTTFESEEVSFKDSSNQEILLIDTVGLSES 64
                69***********************999**************************9997765 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   4.7e-05     0.042      26      46 ..       4      24 ..       1      54 [. 0.88

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 4.7e-05
      AAA_16 26 lvllsGesGvGKsslvrellr 46
                 vl+ G+sGvGKss++++l++
  EFC37768.1  4 RVLIFGQSGVGKSSMINALAN 24
                59****************996 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.8   4.6e-05     0.041       2      29 ..       2      30 ..       1     148 [. 0.57

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 4.6e-05
      AAA_24  2 klkiliyGpsgiGKTtlakel.gpkplfi 29
                 +++li+G+sg+GK+++++ l   k  ++
  EFC37768.1  2 TKRVLIFGQSGVGKSSMINALaNSKLPVL 30
                689****************9953333333 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   6.7e-05      0.06       1      39 [.       4      43 ..       4      64 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 6.7e-05
      AAA_28  1 kivitGgestGKTtlleaLaargypvv.pEaareileekl 39
                ++ i+G ++ GK+++++aLa+ + pv+   +++++ +e+ 
  EFC37768.1  4 RVLIFGQSGVGKSSMINALANSKLPVLdGAVGTTFESEEV 43
                699***********************94455555544444 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   0.00014      0.13       8      29 ..       5      26 ..       2     127 .. 0.86
   2 ?   -1.7   0.0       3.5   3.1e+03     106     113 ..     219     226 ..     182     268 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00014
      AAA_22  8 lvvtGesGtGKTtllrrlleql 29
                ++++G+sG+GK+  ++ l++++
  EFC37768.1  5 VLIFGQSGVGKSSMINALANSK 26
                589***************9986 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 3.5
      AAA_22 106 eealeeLr 113
                 ++++++L+
  EFC37768.1 219 QDLFSKLV 226
                 23333333 PP

>> Septin  Septin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   7.5e-05     0.068       7      30 ..       5      28 ..       1      81 [. 0.81
   2 ?   -2.6   0.1       2.9   2.6e+03     132     158 ..     109     137 ..     102     153 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 7.5e-05
                EEEEEBTTSSCCCCCCTTSSSS-- CS
      Septin  7 lmvvGesglGkttlintlfetdli 30
                +++ G+sg+Gk+++in+l +++l 
  EFC37768.1  5 VLIFGQSGVGKSSMINALANSKLP 28
                899****************99875 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.9
                 HHHHHHH..TTTS-EEEEESSGGGS-HHH CS
      Septin 132 velmkkl..sekvnliPviaKaDtltkeE 158
                 +el+k +  ++kv +i v+ K++ l + E
  EFC37768.1 109 IELFKTIlgDDKVPVIMVVNKSENLEDCE 137
                 55555553357888999999998887666 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   4.8e-05     0.043      54      76 ..       3      25 ..       1      31 [. 0.90
   2 ?   -2.8   0.1       3.1   2.8e+03     114     124 ..     179     189 ..     178     192 .. 0.87
   3 ?   -2.4   0.1       2.4   2.1e+03      70     131 ..     199     263 ..     196     269 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 4.8e-05
      DUF815 54 nnvLLwGarGtGKSslvkallne 76
                + vL++G+ G+GKSs++ al n+
  EFC37768.1  3 KRVLIFGQSGVGKSSMINALANS 25
                679****************9886 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.1
      DUF815 114 DDLsFeeeeee 124
                 DDL+F eee++
  EFC37768.1 179 DDLTFSEEEKK 189
                 9*****99986 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 2.4
      DUF815  70 vkallneyaeeg.Lrlievekedlkelpklvel..lrerperfilfvDDLsFeeeeeeyksLksv 131
                 v a++n+y++++ + li  +++  ++l ++ +l   ++ ++ f + +D  sF +  + + +Lk++
  EFC37768.1 199 VLAMINKYSSKEsVVLIRSSQDLFSKLVRMWNLflFKTGETAFKIGIDLQSFSSVGKLAEKLKVI 263
                 66777888766558888888888888888877521456677777777777777777777777766 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   0.00011       0.1      34      56 ..       3      25 ..       1      46 [. 0.86

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00011
       AAA_7 34 kpvllvGptGtGKtviikdllkk 56
                k vl+ G++G+GK+++i+ l ++
  EFC37768.1  3 KRVLIFGQSGVGKSSMINALANS 25
                78****************96543 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   0.00051      0.45       1      22 [.       5      26 ..       5     160 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00051
      AAA_18  1 IlltGtpGvGKttlakeLskrl 22
                +l+ G +GvGK+++ ++L+++ 
  EFC37768.1  5 VLIFGQSGVGKSSMINALANSK 26
                799***************8773 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (294 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       604  (0.0336884); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 1674.77
//
Query:       EFC37769.1  [L=381]
Description: GTP-binding protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-12   47.0   0.6    3.2e-12   46.2   0.6    1.4  1  AIG1         AIG1 family
    3.1e-12   46.6   0.4    7.8e-12   45.3   0.2    1.8  2  MMR_HSR1     50S ribosome-binding GTPase
    1.3e-08   34.5   0.9    2.7e-08   33.5   0.9    1.6  1  UBA_4        UBA-like domain
    2.4e-05   23.9   1.9    2.7e-05   23.7   0.2    2.0  2  FeoB_N       Ferrous iron transport protein B
    0.00063   19.4   1.7      0.006   16.2   1.6    2.6  1  Ras          Ras family
    0.00095   18.3   2.3      0.001   18.2   0.2    2.1  3  IIGP         Interferon-inducible GTPase (IIGP)
     0.0035   16.7   0.1     0.0078   15.5   0.1    1.7  1  Septin       Septin
     0.0094   16.0   8.3      0.091   12.8   0.6    3.3  3  Dynamin_N    Dynamin family
  ------ inclusion threshold ------
      0.024   14.5   3.7       0.11   12.4   0.4    2.6  2  RsgA_GTPase  RsgA GTPase
      0.026   14.7   3.6       0.08   13.2   0.1    2.9  3  Roc          Ras of Complex, Roc, domain of DAPkinase
      0.029   14.9   5.9       0.21   12.1   1.7    2.8  2  ABC_tran     ABC transporter
       0.03   13.4   0.9       0.19   10.8   0.2    2.1  2  T2SSE        Type II/IV secretion system protein
      0.052   13.0   0.8       0.16   11.4   0.0    2.0  3  Arf          ADP-ribosylation factor family
      0.098   12.4   0.3       0.25   11.1   0.3    1.7  1  AAA_29       P-loop containing region of AAA domain
       0.19   11.6   0.1       0.36   10.7   0.1    1.5  1  Imm17        Immunity protein 17
       0.24   10.8   6.8        0.2   11.1   1.1    2.9  2  SRPRB        Signal recognition particle receptor beta subuni
        1.3    8.3   6.4        7.6    5.8   0.1    2.8  3  AAA_8        P-loop containing dynein motor region D4
        1.6    9.2   9.9       0.14   12.7   3.0    2.5  2  AAA_23       AAA domain


Domain annotation for each model (and alignments):
>> AIG1  AIG1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.2   0.6   3.2e-15   3.2e-12       2     139 ..      79     217 ..      78     245 .. 0.85

  Alignments for each domain:
  == domain 1  score: 46.2 bits;  conditional E-value: 3.2e-15
                 EEEEESSTTSSHHHHHHHHHTS--SS--TTTS---SS-EEEEEEETTEEEEEEE--SCCCTTC....CHHCHHHHHHHHHHHCTT-ESEEEEEEETTB- CS
        AIG1   2 tivlvGktgnGkSaTgNsilgkkaFesklsaqsvtkkcqkksrtwdgkkinViDTPglfdlsv....sadkiskeivrclllseegihalllvlslgrf 96 
                 +i++vG tg+GkS+ +N + g++  +s  +a++ t   ++++ + + +k + iDT g  ++s+    + d + k+i++ + +s  g + +++v+  +++
  EFC37769.1  79 RILVVGITGSGKSSLVNGVTGSTLATSD-NANGCTCGYKRQECEYESQKFELIDTAGFGEVSEvgtvKPDVAFKSIQKLVRYSYSGYNLIVFVTTKKKI 176
                 8***********************9999.7***************************988876454579999*************************** PP

                 SHHHHHHHHHHHHHHCGGGGGGEEEEEEEGGGGTTCCHHHHHH CS
        AIG1  97 teedekalktlkelFGekilkylivvftrkddleddsledyls 139
                 t+ d   +k ++e+  ++ +    v++ +k ++++++++d  +
  EFC37769.1 177 TQTDVDHVKLITEILCKNSIPT--VLLVNKSESGANKIDDICQ 217
                 **************99987765..5666777777777665443 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.3   0.2   7.9e-15   7.8e-12       1     114 []      79     204 ..      79     204 .. 0.73
   2 ?   -2.6   0.0       5.8   5.8e+03      66      74 ..     334     342 ..     271     368 .. 0.59

  Alignments for each domain:
  == domain 1  score: 45.3 bits;  conditional E-value: 7.9e-15
                 EEEEEESTTSSHHHHHHHHHTS.TEEESSSTTSSSSEEEEEEEETTEEEEEEECGGC........SSHHHHHHHHHHHHHHHHC.....TSEEEEEEET CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltge.kaivsdkpgtTrdinegrvklkgkeielvDtpGl........iegaseekglgkaflalee.....adlillvvda 85 
                 ++++vG + +GKS+L+n  tg+  a   + +g+T   ++ + +++ +++el+Dt+G+        +    +     k++++l +      +li++v   
  EFC37769.1  79 RILVVGITGSGKSSLVNGVTGStLATSDNANGCTCGYKRQECEYESQKFELIDTAGFgevsevgtV----KPDVAFKSIQKLVRysysgYNLIVFVTT- 172
                 689*******************668889999************999**********5333222221....2222222222222222323588888887. PP

                 TTTCSHHHHHHHHHHHHH....TTSEEEEEEES CS
    MMR_HSR1  86 seeklkpldeeleellee....akkplilvlnk 114
                 + +k+++ d +  +l++e    + +p++l++nk
  EFC37769.1 173 K-KKITQTDVDHVKLITEilckNSIPTVLLVNK 204
                 4.6799999998888877887799999999998 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 5.8
                 HHHHHHHHH CS
    MMR_HSR1  66 lgkaflale 74 
                  ++++++le
  EFC37769.1 334 KKREIKELE 342
                 233333332 PP

>> UBA_4  UBA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.5   0.9   2.7e-11   2.7e-08       2      42 ..      19      60 ..      18      61 .. 0.94

  Alignments for each domain:
  == domain 1  score: 33.5 bits;  conditional E-value: 2.7e-11
       UBA_4  2 eliaqFqaiT.GadeekArqlLeannWdLerAislyFdsgea 42
                ++i  F ++T ++d   A+++L+++n+d+  Ai+ yFd++e+
  EFC37769.1 19 QQITAFNSVTyNTDNTIAIKYLNQSNGDVSKAIENYFDEQEQ 60
                68999*****99***************************987 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       2.1   2.1e+03      17      68 ..      11      34 ..       5      48 .. 0.54
   2 !   23.7   0.2   2.7e-08   2.7e-05       2      72 ..      79     151 ..      78     223 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.1
                HHHHHTTSEEEEESTTSSSEEEEEEEEETTEEEEEEE----SSSSSSSHHHH CS
      FeoB_N 17 fnaltgakqkvgNwpGvtvekkegklklkgkeveivDlPGiYslsayseeek 68
                +n+   ++q++  +  vt +                             +++
  EFC37769.1 11 INSSNSKTQQITAFNSVTYNT----------------------------DNT 34
                555555555555555555443............................333 PP

  == domain 2  score: 23.7 bits;  conditional E-value: 2.7e-08
                 EEEEEESTTSSHHHHHHHHHTTSEEEE.ESTTSSSEEEEEEEEETTEEEEEEE----SSSSSS.SHHHHHHHH CS
      FeoB_N   2 tvalvGnpnvGkttlfnaltgakqkvg.NwpGvtvekkegklklkgkeveivDlPGiYslsay.seeekvard 72 
                 ++ +vG   +Gk++l+n +tg++   + N  G t   k+ +++++++++e++D  G  ++s++ +    va +
  EFC37769.1  79 RILVVGITGSGKSSLVNGVTGSTLATSdNANGCTCGYKRQECEYESQKFELIDTAGFGEVSEVgTVKPDVAFK 151
                 7899*******************88764999************************998886642344455544 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   1.6     6e-06     0.006       1      65 [.      79     142 ..      79     235 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 6e-06
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslr 65 
                 ++++vG ++ GK+sl++  + ++  ++ ++  g+    k+ e++ ++ k+e+ DTAG  e +++ 
  EFC37769.1  79 RILVVGITGSGKSSLVNGVTGSTLATS-DNANGCTCGYKRQECEYESQKFELIDTAGFGEVSEVG 142
                 589**************9998888776.55667999999999999999*********87755443 PP

>> IIGP  Interferon-inducible GTPase (IIGP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.2     1e-06     0.001       4      86 ..      47     128 ..      44     192 .. 0.79
   2 ?   -2.1   0.0       1.5   1.5e+03     278     301 ..     228     252 ..     217     290 .. 0.62
   3 ?   -2.3   0.0       1.7   1.7e+03     184     203 ..     338     357 ..     328     359 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 1e-06
                 HHHHHHHHHHHT-HHHHHHHHHHHHHHHHT--EEEEEEESTTSSHHHHHHHHTT--TTSTTS--SSCHSHHTS-EEEE-SS-T CS
        IIGP   4 vikliekalkegnlqkvvsiikeaikeiesaklkiavtGdsGnGkssFinaLRliGheeedsAptGvvettkkrtpYssskfP 86 
                 v+k ie++  e + q++ s  +  i++ +s +++i v+G +G+Gkss +n + +      d A+  +    +++ +Y+s kf 
  EFC37769.1  47 VSKAIENYFDEQEQQSTDSD-RSSISNPSSDVIRILVVGITGSGKSSLVNGVTGSTLATSDNANGCTCGYKRQECEYESQKFE 128
                 67788888888887776665.7789**************************99999999999999999999999999998884 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.5
                 HHHHHHHHTT-SH.HHHHHHHHHTT CS
        IIGP 278 slklyrkvFGlDd.eslqevArdlg 301
                  l+ + k FG D   ++q++A   g
  EFC37769.1 228 NLNEFYKAFGKDTfRAIQQIAFPKG 252
                 5566666666665345666664333 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.7
                 HHTTSSS--EEEBBTTBTTS CS
        IIGP 184 qkekvkeppvFLvsnldvsa 203
                 +ke  +e+  FLvs+l++s+
  EFC37769.1 338 IKELEEEHSNFLVSTLSISK 357
                 5777889999****999875 PP

>> Septin  Septin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   7.8e-06    0.0078       6      78 ..      79     141 ..      76     206 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 7.8e-06
                 EEEEEEBTTSSCCCCCCTTSSSS------------------S-EEEEEEEEETTCEEEEEEEE---BSSSSSH CS
      Septin   6 tlmvvGesglGkttlintlfetdlieeekleeasekkkktveikkkkvvieedgvklnltviDtpgfGdavdn 78 
                  ++vvG  g Gk++l+n +  ++l ++++ +        t   k+++ + e +    ++ +iDt gfG+  + 
  EFC37769.1  79 RILVVGITGSGKSSLVNGVTGSTLATSDNAN------GCTCGYKRQECEYESQ----KFELIDTAGFGEVSEV 141
                 69********************999986333......3355556666666655....4567*******97654 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.4      0.55   5.5e+02      28      60 ..      27      59 ..       7      75 .. 0.60
   2 !   12.8   0.6   9.1e-05     0.091       1      28 [.      80     106 ..      80     113 .. 0.83
   3 ?    5.6   0.0     0.015        15      95     166 ..     119     203 ..     115     205 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.55
                SSS---S-EEEEECCT---CCS...SSEEEET- CS
   Dynamin_N 28 pnptTrrplelqlgeeeeaseravkeelkekek 60
                 +  T +++ +++ ++++   ++++e++ ++++
  EFC37769.1 27 VTYNTDNTIAIKYLNQSNGDVSKAIENYFDEQE 59
                444566666666666666555555555555522 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 9.1e-05
                 EEEEEBTTTTHHHHHHHHHTS--S---S CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlgedilprgp 28 
                 i+vvG + sGKSS++n ++g+  l ++ 
  EFC37769.1  80 ILVVGITGSGKSSLVNGVTGST-LATSD 106
                 89******************99.44444 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.015
                 EEETTS-SEEEEE---B-SSSGTTS...........HHHHHHHSTTEEEEEEEETTS.-CCC-CHHHHHHHHSTTBTT.EEEEEE CS
   Dynamin_N  95 ilsllvkgltlvDlPGldsvnkrdq...........elvkeyikkadiilavtsanh.dlsnsealflarevdpkgkr.tivvlt 166
                  ++   ++ +l+D+ G+ +v +  +           +lv+      ++i++vt  ++   ++++  +l  e+  k++  t+ +++
  EFC37769.1 119 ECEYESQKFELIDTAGFGEVSEVGTvkpdvafksiqKLVRYSYSGYNLIVFVTTKKKiTQTDVDHVKLITEILCKNSIpTVLLVN 203
                 577888999**********9999999**999988876666666778888888766663667778889999999888886555555 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.4   0.00011      0.11     102     132 ..      80     109 ..      53     141 .. 0.62
   2 ?    2.1   0.2      0.16   1.6e+02      28     100 ..     146     219 ..     140     222 .. 0.65

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00011
                  EEEECSTTSSHHHHHHHHCTT-----S---- CS
  RsgA_GTPase 102 svlvGqSGvGKStLinallpelelktgevse 132
                  +++vG +G GKS+L+n ++++ +l+t++  +
   EFC37769.1  80 ILVVGITGSGKSSLVNGVTGS-TLATSDNAN 109
                  5679**************998.555554433 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.16
                  TT--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHH..HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTTS CS
  RsgA_GTPase  28 pelslnlldrfLvlaeekgiepvivlnKiDlleeee..eleelkeelealgyevllvsaktkegleelkellkdk 100
                  p++  + +++ Lv +  +g ++++ ++    +++++  +++ + e l +  ++++l+ +k+++g++++ + +++k
   EFC37769.1 146 PDVAFKSIQK-LVRYSYSGYNLIVFVTTKKKITQTDvdHVKLITEILCKNSIPTVLLVNKSESGANKIDDICQNK 219
                  6666666665.5666667776666665444444444457777777777888887777777788888887777765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       4.2   4.2e+03      28      39 ..      31      42 ..      11      66 .. 0.48
   2 ?   13.2   0.1     8e-05      0.08       1      70 [.      79     139 ..      79     145 .. 0.70
   3 ?    1.1   0.1      0.43   4.3e+02      70     118 ..     154     205 ..     147     207 .. 0.63

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 4.2
                EETTTTEEEEEE CS
         Roc 28 ekstigvdfltk 39
                +++ti++++l++
  EFC37769.1 31 TDNTIAIKYLNQ 42
                223333333332 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 8e-05
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTT CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfr 70 
                 ++++vG +g+GK+sl++ ++ ++  ++ ++  g++   k+     ++e     ++ k+++ DtaG  +++
  EFC37769.1  79 RILVVGITGSGKSSLVNGVTGSTLATSDNA-NGCTCGYKRQ----ECEY----ESQKFELIDTAGFGEVS 139
                 689*****************9998766544.4555554442....2222....33469999999976655 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.43
                 TTT-HHHHCTSCEEEEEEEGHHHHCH.HHHHHHHHHH.CSSS.-EEEEEE-T CS
         Roc  70 rslhplylreaalailvydsrssenl.keWlkelkkv.agks.pvilvgnki 118
                 ++l ++ +++ +l+++v+++++ ++   + +k +++  +++s p +l++nk 
  EFC37769.1 154 QKLVRYSYSGYNLIVFVTTKKKITQTdVDHVKLITEIlCKNSiPTVLLVNKS 205
                 4556666778888888888665433313566666664355544889999997 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.2       3.1   3.1e+03      66     110 ..      19      71 ..       7      83 .. 0.57
   2 ?   12.1   1.7   0.00021      0.21      14      43 ..      80     124 ..      70     371 .. 0.61

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 3.1
                 SS--S-TTSB.HHHH........HHHTCHHHHHHHSTTGGTTCBGESTTSGGS- CS
                 xxxxxxxxxx.xxxx........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  66 qepqlfpelt.vren........esdeeiekalsklglkelkdtvvksspssLS 110
                 q+ + f+ +t + +n        +s+ +++ka++++ +++ +++  +s+ ss+S
  EFC37769.1  19 QQITAFNSVTyNTDNtiaikylnQSNGDVSKAIENYFDEQ-EQQSTDSDRSSIS 71 
                 4445555555444446666666655555666665555444.4444445555555 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 0.00021
                 EEEEESTTSSHHHHHHHHTTSS--SEEEE...............E CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx...............x RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkpteGei...............l 43 
                 + +vG +G+GKS+L++ ++g +  t+++                 
  EFC37769.1  80 ILVVGITGSGKSSLVNGVTGSTLATSDNAngctcgykrqeceyeS 124
                 6789****************9999988874444433333333330 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.2   0.00019      0.19     105     150 ..      51      98 ..      11     109 .. 0.70
   2 ?    0.8   0.0       0.2     2e+02      31      66 ..     330     365 ..     321     375 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00019
       T2SSE 105 lddlgaeealk..ekiaevlrkavrerglilvsGgTgsGKttllyall 150
                 ++++  e++++  +  ++ ++++ +    ilv G TgsGK+ l++ + 
  EFC37769.1  51 IENYFDEQEQQstDSDRSSISNPSSDVIRILVVGITGSGKSSLVNGVT 98 
                 44454433333224556678888788899*************998664 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.2
       T2SSE  31 vdgielreveelekaalerlisriaalakldiseer 66 
                    ++ re++ele+++ ++l+s++ ++ k+ ++  +
  EFC37769.1 330 EKTMKKREIKELEEEHSNFLVSTLSISKKQAVQIAK 365
                 4558899*****************999999887555 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00016      0.16      14      67 ..      77     134 ..      68     144 .. 0.87
   2 ?   -1.6   0.1       1.6   1.6e+03      74     126 ..     156     206 ..     147     222 .. 0.64
   3 ?   -3.2   0.1         5     5e+03     102     151 ..     336     361 ..     329     370 .. 0.39

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00016
                 EEEEEEEESTTSSHHHHHHHHHHSSCEE....CSSSSSEEEEEEEETTEEEEEEEE-S CS
         Arf  14 elrilllGLDnaGKtTilkklkleelvt....tvPTigfnveeleiknlkftvwDvGG 67 
                  +ril++G+ ++GK+ +++ ++   l+t       T+g++ +e e++  kf++ D  G
  EFC37769.1  77 VIRILVVGITGSGKSSLVNGVTGSTLATsdnaNGCTCGYKRQECEYESQKFELIDTAG 134
                 58******************99999988555567899****************99887 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.6
                 GGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHHCTSGCCT.TSEEEEEEE-TT CS
         Arf  74 lWknYfektdavifvvDsadreRleeakeeLkalleeeelk.evallvlaNKqD 126
                 l +  ++  + ++fv   + +++++++  +  +l++e   k +++ ++l NK +
  EFC37769.1 156 LVRYSYSGYNLIVFV---TTKKKITQTDVDHVKLITEILCKnSIPTVLLVNKSE 206
                 555556666666666...456667777766666666665552566777777754 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 5
                 HHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSE CS
         Arf 102 eeLkalleeeelkevallvlaNKqDlpealseeelrellgleelkgkrkl 151
                 +e+k+l ee+ +  v  l ++                         k+ +
  EFC37769.1 336 REIKELEEEHSNFLVSTLSISK------------------------KQAV 361
                 3333333333333333333333........................3333 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.3   0.00025      0.25      24      42 ..      79      97 ..      66     109 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00025
      AAA_29 24 atlltGpsGsGKSTllDAi 42
                 +l++G +GsGKS+l+  +
  EFC37769.1 79 RILVVGITGSGKSSLVNGV 97
                4799***********9766 PP

>> Imm17  Immunity protein 17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   0.00036      0.36      15      47 ..     215     246 ..     214     249 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00036
       Imm17  15 ilnwdWfftprgakngrfwvenfGrkgaRifyg 47 
                 i+  +W+ +++ga n++ +++ fG++++R ++ 
  EFC37769.1 215 ICQNKWLNDNNGA-NLNEFYKAFGKDTFRAIQQ 246
                 7999**9999999.999************9875 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   1.1    0.0002       0.2       5      63 ..      79     139 ..      75     224 .. 0.56
   2 ?    1.1   0.5      0.23   2.3e+02     139     177 ..     336     375 ..     326     378 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.0002
                 EEEEE-STTSSHHHHHHHHHHSS---B---SS-EEETTG.....GGTT-SEEEETT-GCCS CS
       SRPRB   5 avllvGlsdsGKTslftrLttdsvkktvtSqessaalkv..ksekgskltliDfPGheklr 63 
                 ++l+vG++ sGK sl + +t  +  ++  +   ++ +k    + + +k++liD  G  ++ 
  EFC37769.1  79 RILVVGITGSGKSSLVNGVTGSTLATSDNANGCTCGYKRqeCEYESQKFELIDTAGFGEVS 139
                 79***************9998877777666655555554334568899*****99865543 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.23
                 HHHHHHHHCHHHHHH--.----T....T--------GGGS CS
       SRPRB 139 kElnkiierrskalkel.deeedksavlakkgkdFkfdql 177
                 +E++++ e +s+ l ++   ++++ +++ak++  ++f++l
  EFC37769.1 336 REIKELEEEHSNFLVSTlSISKKQAVQIAKESVTYEFSEL 375
                 6899999999988876646677888999999999999998 PP

>> AAA_8  P-loop containing dynein motor region D4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.3       3.1   3.1e+03     209     250 ..      13      54 ..       7      59 .. 0.67
   2 ?    5.8   0.1    0.0077       7.6      26      41 ..      79      94 ..      70     106 .. 0.87
   3 ?    5.4   0.1      0.01       9.9      69     149 ..     152     234 ..     143     244 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3.1
       AAA_8 209 ieeelkesivkvlvevhssveelsekfleelkrkiyvtpksy 250
                  +++  ++i+ + + ++++ ++++ k+l++ +  +    ++y
  EFC37769.1  13 SSNSKTQQITAFNSVTYNTDNTIAIKYLNQSNGDVSKAIENY 54 
                 455566677777777777778888888888776666555555 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0077
       AAA_8 26 haLlvGvgGsGrqslt 41
                 +L+vG+ GsG+ sl+
  EFC37769.1 79 RILVVGITGSGKSSLV 94
                5799**********97 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.01
       AAA_8  69 dlkkllkkagikqkevvfllsdnqiieesf..ledinnlLntGevpnLfskeekeeiieelrkeakkqgvedskesllnffik 149
                  ++kl+++     + +vf+ ++++i+++++  ++ i ++L +  +p+++  +  e+  +++ + ++++  +d++ + ln f k
  EFC37769.1 152 SIQKLVRYSYSGYNLIVFVTTKKKITQTDVdhVKLITEILCKNSIPTVLLVNKSESGANKIDDICQNKWLNDNNGANLNEFYK 234
                 578888888888889**********9886544999***************************999999888887777777765 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.6       1.5   1.4e+03     101     164 ..      16      60 ..       5      77 .. 0.38
   2 ?   12.7   3.0   0.00014      0.14      23     146 ..      81     222 ..      79     367 .. 0.52

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.5
      AAA_23 101 gkttkkaklelleideleqfisellgskkiilnlilflgqerfeefelkdkkerleelekelee 164
                 +kt++ +++++++ ++ + +  ++l+++                   + d ++++e++ +e+e+
  EFC37769.1  16 SKTQQITAFNSVTYNTDNTIAIKYLNQS-------------------NGDVSKAIENYFDEQEQ 60 
                 3333333333333322222222222211...................11122222222222222 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 0.00014
      AAA_23  23 lItGpNGaGKTTildAiklaLygetprlsrksgrgfeksdveiese..........gkvkayvelt....fenkdgrytrsiererelskkkgkttkka 107
                 l++G +G+GK+++++ ++  +    +++ ++   g++++++e es+          g+v+++ +++    f+++++     ++++ + +      t k+
  EFC37769.1  81 LVVGITGSGKSSLVNGVTGSTLAT-SDNANGCTCGYKRQECEYESQkfelidtagfGEVSEVGTVKpdvaFKSIQKL----VRYSYSGYNLIVFVTTKK 174
                 789***************998874.5555566557888888755555667666777444444222244447777774....333333333333222233 PP

      AAA_23 108 klelleideleqfisellgskkiilnlilflgqer...........feef 146
                 k  ++++d   ++i+e+l+++ i  +++l  ++e+           ++ +
  EFC37769.1 175 KITQTDVDH-VKLITEILCKNSI-PTVLLVNKSESgankiddicqnKWLN 222
                 333333332.3344433332222.11111111111222222222221111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1158  (0.0645881); expected 358.6 (0.02)
Passed bias filter:                      589  (0.0328518); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              18  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2324.71
//
Query:       EFC37770.1  [L=343]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-06   27.3   0.0    7.5e-06   24.8   0.0    1.9  2  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   0.0   4.2e-10   7.5e-06      92     163 ..     159     231 ..      82     238 .. 0.81
   2 ?    0.1   0.0     0.013   2.3e+02     360     390 ..     312     341 ..     301     343 .] 0.76

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 4.2e-10
       Actin  92 peehplllteppln.ppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGy 163
                 +++ +ll++ p l   ++ r+k+++++fE  +v  l+++k   ++afa  k++++++ s   +t +vpV++G 
  EFC37770.1 159 NKKIRLLIVGPELDyDNEIRKKMTQLLFECSNVTHLCITKPSEMAAFALEKKNAIIIHSDGISTNIVPVIEGE 231
                 5667777777776515678****************************************************95 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.013
       Actin 360 iiapeeerkysaWiGGSiLAslgtfqqlwvs 390
                 i ++e ++   +W+G+  +A  ++  q wvs
  EFC37770.1 312 ISKSEYKPEELVWMGACKFATYSSN-QRWVS 341
                 44444589999*********98764.56776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       525  (0.0292822); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 2236.82
//
Query:       EFC37771.1  [L=1236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-20   72.5 191.2    0.00031   21.1   6.8   13.9 14  EGF_2     EGF-like domain
  ------ inclusion threshold ------
      0.061   12.5   0.0       0.11   11.7   0.0    1.3  1  DUF4899   Domain of unknown function (DUF4899)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.9   6.2   0.00011      0.96       5      32 .]      22      49 ..      17      49 .. 0.80
   2 !   11.7   5.4   2.8e-05      0.25       7      24 ..      64      86 ..      59      94 .. 0.74
   3 !   17.6   8.8   4.2e-07    0.0038       5      32 .]     110     136 ..     106     136 .. 0.88
   4 !    8.1  11.3   0.00039       3.5       5      32 .]     151     178 ..     143     178 .. 0.82
   5 !   19.2  10.1   1.3e-07    0.0012       6      32 .]     192     217 ..     188     217 .. 0.91
   6 !   11.1  10.3   4.4e-05      0.39       6      32 .]     242     267 ..     237     267 .. 0.86
   7 !   11.3   7.9   3.8e-05      0.34       4      26 ..     279     300 ..     272     311 .. 0.82
   8 !   21.1   6.8   3.4e-08   0.00031       7      32 .]     331     355 ..     326     355 .. 0.94
   9 !   16.2  10.7   1.2e-06      0.01       5      32 .]     368     399 ..     360     399 .. 0.89
  10 ?   -1.1   0.1      0.29   2.6e+03      22      32 .]     401     411 ..     401     411 .. 0.91
  11 !    5.5  10.0    0.0025        23       1      32 []     417     446 ..     416     446 .. 0.84
  12 ?   -0.9   0.1      0.25   2.3e+03      23      32 .]     449     458 ..     448     458 .. 0.88
  13 !   11.0   6.6   4.7e-05      0.42       1      26 [.     462     485 ..     462     496 .. 0.80
  14 ?    3.3   3.2     0.012   1.1e+02      22      32 .]     498     508 ..     492     508 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00011
       EGF_2  5 deiCgghGtCvnqcG.qCdCdsgyq.GktC 32
                ++ Cg  G+Cv  ++  C+Cd++   G +C
  EFC37771.1 22 STSCGAFGKCV--GNdTCSCDPNVAiGTKC 49
                567********..5426***9998878888 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 2.8e-05
       EGF_2  7 iCgghGtCvnqcGqCdC.......d 24
                 Cgg+G+C   +G C C       +
  EFC37771.1 64 VCGGRGVCY--NGDCACtlderfgS 86
                6********..******95443333 PP

  == domain 3  score: 17.6 bits;  conditional E-value: 4.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +CgghGtCv+++  CdC  gy G +C
  EFC37771.1 110 EYECGGHGTCVETN-ICDCHVGYGGYDC 136
                 578*******9666.9*********999 PP

  == domain 4  score: 8.1 bits;  conditional E-value: 0.00039
       EGF_2   5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 +  C+g+G+C++q   C C ++ y G +C
  EFC37771.1 151 SKVCSGRGQCIDQDY-CLCqSDDYGGVDC 178
                 678********9996.***7777778888 PP

  == domain 5  score: 19.2 bits;  conditional E-value: 1.3e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G+C +++ +C C sg++G +C
  EFC37771.1 192 GVCNGRGQCLQPN-NCTCTSGFSGTNC 217
                 57********888.8************ PP

  == domain 6  score: 11.1 bits;  conditional E-value: 4.4e-05
       EGF_2   6 eiCgghGtCvnqcGq.CdCdsgyqGktC 32 
                 + C+g G+C   ++  C+C+ gy+G+ C
  EFC37771.1 242 NVCSGKGSCF--GNDyCSCQIGYTGARC 267
                 68*******9..5446************ PP

  == domain 7  score: 11.3 bits;  conditional E-value: 3.8e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsg 26 
                 sd +C+g+G+C +++  C+C+++
  EFC37771.1 279 SDKTCSGNGVCSSLN-TCSCNNN 300
                 4899*******9888.9***764 PP

  == domain 8  score: 21.1 bits;  conditional E-value: 3.4e-08
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+G C++  G C+C+ gy+G +C
  EFC37771.1 331 VCSGRGACIDHLG-CVCNEGYYGESC 355
                 6*******99999.***********9 PP

  == domain 9  score: 16.2 bits;  conditional E-value: 1.2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                 +  C+ghG+C ++  +C+C     +  ++G++C
  EFC37771.1 368 SQVCNGHGICQDLD-NCECysnstNGYWYGDDC 399
                 789*******9999.8***************** PP

  == domain 10  score: -1.1 bits;  conditional E-value: 0.29
       EGF_2  22 dCdsgyqGktC 32 
                 +C ++y G+ C
  EFC37771.1 401 VCANSYEGNLC 411
                 5999*****99 PP

  == domain 11  score: 5.5 bits;  conditional E-value: 0.0025
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C + +++C   G C n    C+C+s++ G +C
  EFC37771.1 417 CNS-STTCMSLGECSNND-LCRCESSFDGENC 446
                 654.589999****8444.6***********9 PP

  == domain 12  score: -0.9 bits;  conditional E-value: 0.25
       EGF_2  23 CdsgyqGktC 32 
                 C  gy+G+ C
  EFC37771.1 449 CALGYYGPLC 458
                 888******9 PP

  == domain 13  score: 11.0 bits;  conditional E-value: 4.7e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsg 26 
                 Csa +++C+ +G+C    G CdC ++
  EFC37771.1 462 CSA-ELNCSSNGVCS-RDGFCDCYQS 485
                 999.689*******7.368****654 PP

  == domain 14  score: 3.3 bits;  conditional E-value: 0.012
       EGF_2  22 dCdsgyqGktC 32 
                 +C++gy+G++C
  EFC37771.1 498 KCSPGYFGNDC 508
                 6********** PP

>> DUF4899  Domain of unknown function (DUF4899)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   1.2e-05      0.11      35     141 ..     682     790 ..     680     813 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.2e-05
     DUF4899  35 llvvPkryanklesvdleedyiefkekleelkekllkeisevedltkeflaflksvikkkg..kellgaelsaavkdsDvelvkvilseileeWspkve 131
                 ++++P++++  ++ ++l++ ++++ +++ + k+ +l+++s+++   +++   + +  ++    + +l  ++   +  + v+++++i s    eWs   +
  EFC37771.1 682 VISIPSSFTSSVNLINLKLRIANYYQQFGSEKQVILQDLSTASSSVNQVQIKITTARNRLYilNDILPYKINCKLTVNGVQVTNIISSGYSIEWSLSPD 780
                 689*************************************99988888776555555553212455666777777777888888888888888887777 PP

     DUF4899 132 vevvaeklty 141
                 + +   +lt+
  EFC37771.1 781 LGIGLANLTL 790
                 7766666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       756  (0.0421663); expected 358.6 (0.02)
Passed bias filter:                      274  (0.0152825); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.84u 0.30s 00:00:01.13 Elapsed: 00:00:00.49
# Mc/sec: 7589.72
//
Query:       EFC37772.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.9e-33  109.7  11.2      8e-05   22.4   0.0    9.5 10  LRR_6     Leucine Rich repeat
    3.2e-24   84.4  10.5    4.4e-08   32.8   0.1    4.4  6  LRR_8     Leucine rich repeat
    1.4e-19   69.8  10.7    0.00079   19.8   0.0    6.6  7  LRR_4     Leucine Rich repeats (2 copies)
    1.1e-12   46.6   2.2        1.9    9.4   0.0    8.8 10  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1       3.1   1.4e+04       1       6 [.      24      29 ..      24      30 .. 0.83
   2 ?    2.8   0.0     0.034   1.5e+02       6      19 ..      48      61 ..      46      61 .. 0.89
   3 !   10.1   0.0   0.00015      0.68       4      23 ..      70      89 ..      67      90 .. 0.91
   4 !   13.4   0.0   1.4e-05     0.061       3      23 ..      93     113 ..      91     114 .. 0.92
   5 !   22.4   0.0   1.8e-08     8e-05       4      24 .]     118     138 ..     115     138 .. 0.93
   6 !    5.5   0.0    0.0047        21      12      23 ..     150     161 ..     142     162 .. 0.83
   7 !   19.3   0.0   1.7e-07   0.00078       5      23 ..     167     185 ..     164     186 .. 0.93
   8 !   13.5   0.0   1.3e-05     0.059       4      24 .]     190     210 ..     187     210 .. 0.89
   9 !   12.0   0.1   3.7e-05      0.17       4      23 ..     214     233 ..     211     233 .. 0.90
  10 !    8.6   0.0   0.00048       2.2       3      19 ..     237     253 ..     235     257 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.1
       LRR_6  1 snthLt 6 
                sn++Lt
  EFC37772.1 24 SNQTLT 29
                699998 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.034
       LRR_6  6 teLdLsgNdIgDeG 19
                 +Ld+s+ +IgD+G
  EFC37772.1 48 ITLDISYQKIGDAG 61
                58**********98 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.00015
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                +Lt+L + gN+I+ eGa+++
  EFC37772.1 70 KLTKLYVCGNEISSEGAKSI 89
                79****************98 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 1.4e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt+L+++ N++g eGa+++
  EFC37772.1  93 KNLTYLSVRINHLGSEGAKSI 113
                 58*****************98 PP

  == domain 5  score: 22.4 bits;  conditional E-value: 1.8e-08
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L++L +++N+IgDeG+++++
  EFC37772.1 118 KLRTLYIAHNQIGDEGIKSIS 138
                 7*****************996 PP

  == domain 6  score: 5.5 bits;  conditional E-value: 0.0047
       LRR_6  12 gNdIgDeGaeaL 23 
                 +N+Ig  Ga+++
  EFC37772.1 150 YNQIGSGGAKSI 161
                 8*********98 PP

  == domain 7  score: 19.3 bits;  conditional E-value: 1.7e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 LteL +s N+I DeGa+++
  EFC37772.1 167 LTELGISENNIEDEGAKSI 185
                 9****************98 PP

  == domain 8  score: 13.5 bits;  conditional E-value: 1.3e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L++L+ s + IgDeGae+++
  EFC37772.1 190 YLRKLSASRCRIGDEGAESIS 210
                 6888999***********996 PP

  == domain 9  score: 12.0 bits;  conditional E-value: 3.7e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt+L+++ N I DeGa  +
  EFC37772.1 214 NLTKLSINTNPIKDEGALHI 233
                 8***************9865 PP

  == domain 10  score: 8.6 bits;  conditional E-value: 0.00048
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                 + L++Ld++ + I  eG
  EFC37772.1 237 PQLKKLDITRCSIKSEG 253
                 679************99 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0    0.0002       0.9      24      61 .]      44      81 ..      18      81 .. 0.84
   2 !   22.0   0.1   2.3e-08    0.0001       3      61 .]      47     105 ..      45     105 .. 0.96
   3 !   32.8   0.1   9.9e-12   4.4e-08       2      61 .]      70     129 ..      69     129 .. 0.98
   4 !   25.4   0.2     2e-09   8.8e-06       2      61 .]      94     153 ..      94     153 .. 0.97
   5 !   16.9   0.0     9e-07     0.004       2      61 .]     142     201 ..     141     201 .. 0.96
   6 !   14.2   0.1   6.3e-06     0.028       3      61 .]     191     249 ..     189     249 .. 0.93

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0002
                -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8 24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                ++ L +Ld+s+ ++     +++ +L +L++L++ gN +
  EFC37772.1 44 MKELITLDISYQKIGDAGSNTIGQLIKLTKLYVCGNEI 81
                78899999999999999999999999999999999876 PP

  == domain 2  score: 22.0 bits;  conditional E-value: 2.3e-08
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L +Ld+s  ++ + +  +  +l +L+ L+   N++++  ++++ +L++L++L ++ N+L
  EFC37772.1  47 LITLDISYQKIGDAGSNTIGQLIKLTKLYVCGNEISSEGAKSIGQLKNLTYLSVRINHL 105
                 679***************************************************99997 PP

  == domain 3  score: 32.8 bits;  conditional E-value: 9.9e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+++ N ++s + ++  +l+nL++L+ + N l +  ++++ +L++Lr L++ +N++
  EFC37772.1  70 KLTKLYVCGNEISSEGAKSIGQLKNLTYLSVRINHLGSEGAKSIGQLEKLRTLYIAHNQI 129
                 79********************************************************98 PP

  == domain 4  score: 25.4 bits;  conditional E-value: 2e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+L+++ N+l s + ++  +l++L++L++ +N++     +++s+L+ L+ L+ ++N++
  EFC37772.1  94 NLTYLSVRINHLGSEGAKSIGQLEKLRTLYIAHNQIGDEGIKSISQLKELTTLYTDYNQI 153
                 89************************************9999****************97 PP

  == domain 5  score: 16.9 bits;  conditional E-value: 9e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+ + N++ s + ++   +++L++L +s+N+++   ++++ +L  Lr+L  s++r+
  EFC37772.1 142 ELTTLYTDYNQIGSGGAKSIGEMKQLTELGISENNIEDEGAKSIGQLIYLRKLSASRCRI 201
                 799***************************************************999987 PP

  == domain 6  score: 14.2 bits;  conditional E-value: 6.3e-06
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L++L+ s+ r+ + + e+ ++l nL+ L+++ N ++   +  +  Lp+L++Ld++++ +
  EFC37772.1 191 LRKLSASRCRIGDEGAESISKLINLTKLSINTNPIKDEGALHIIKLPQLKKLDITRCSI 249
                 889999999999999***********************999*************99865 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.3    0.0069        31       8      38 ..      34      59 ..      17      63 .. 0.58
   2 !   13.0   0.0   2.4e-05      0.11       2      39 ..      46      81 ..      45      89 .. 0.86
   3 !   15.9   0.1     3e-06     0.013       2      36 ..      70     105 ..      69     110 .. 0.85
   4 !   19.8   0.0   1.8e-07   0.00079       2      37 ..     118     154 ..     117     157 .. 0.84
   5 !    6.6   0.0    0.0025        11      11      36 ..     151     177 ..     149     181 .. 0.67
   6 !   19.1   0.0   2.8e-07    0.0013       3      38 ..     191     227 ..     191     232 .. 0.86
   7 !   17.2   0.9   1.1e-06    0.0051       2      38 ..     214     248 ..     213     253 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0069
                --SS---E-S-HHH-TT--EEE-.-S----- CS
       LRR_4  8 LsnNqltdiplleklpnLkeLdLsgNnlitd 38
                Ls N ++++ l   ++ L +Ld+s   +i+d
  EFC37772.1 34 LS-NVIKSLIL---MKELITLDISYQ-KIGD 59
                22.34555444...999999999776.6655 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 2.4e-05
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39
                 L++Ld+s  ++ d ++  +++l +L++L++ gN     +
  EFC37772.1 46 ELITLDISYQKIGDAGSntIGQLIKLTKLYVCGN----EI 81
                79******66****99988778********9899....44 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 3e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L+  +N +++ +   +++l+nL++L++ + n +
  EFC37772.1  70 KLTKLYVCGNEISSEGAksIGQLKNLTYLSV-RINHL 105
                 8*************99986668********9.64455 PP

  == domain 4  score: 19.8 bits;  conditional E-value: 1.8e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L++L++++Nq+ d +   +++l+ L++L+   N +i+
  EFC37772.1 118 KLRTLYIAHNQIGDEGIksISQLKELTTLYTDYN-QIG 154
                 8**********99988876557*******99556.775 PP

  == domain 5  score: 6.6 bits;  conditional E-value: 0.0025
                 S---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  11 Nqltdipl..leklpnLkeLdLsgNnli 36 
                 Nq+ + +   ++ +++L+eL +s+N +i
  EFC37772.1 151 NQIGSGGAksIGEMKQLTELGISEN-NI 177
                 5566544443334999****99999.44 PP

  == domain 6  score: 19.1 bits;  conditional E-value: 2.8e-07
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 L++L+ s +++ d +   ++kl nL++L++ + n+i+d
  EFC37772.1 191 LRKLSASRCRIGDEGAesISKLINLTKLSI-NTNPIKD 227
                 99***********99976558*********.5558876 PP

  == domain 7  score: 17.2 bits;  conditional E-value: 1.1e-06
                 S--EEE--SS---E-S-HH..H-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitd 38 
                 nL++L+++ N ++d + l   klp+Lk+Ld++++    +
  EFC37772.1 214 NLTKLSINTNPIKDEGALHiiKLPQLKKLDITRC----S 248
                 9*******66****99977779*********888....4 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1       1.2   5.3e+03       2      15 ..      18      33 ..      12      41 .. 0.63
   2 ?    4.6   0.0     0.015        69       2      21 ..      47      66 ..      46      68 .. 0.87
   3 ?    5.0   0.0     0.012        52       1      21 [.      70      90 ..      70      92 .. 0.86
   4 ?    0.6   0.0      0.31   1.4e+03       1      21 [.      94     114 ..      94     116 .. 0.82
   5 !    9.4   0.0   0.00041       1.9       1      22 [.     118     139 ..     118     140 .. 0.89
   6 ?   -2.2   0.0       2.6   1.2e+04       2      20 ..     143     161 ..     142     163 .. 0.75
   7 ?    1.7   0.0      0.14   6.3e+02       2      21 ..     167     186 ..     166     188 .. 0.85
   8 ?    5.0   0.0     0.011        50       2      23 .]     191     212 ..     190     212 .. 0.94
   9 ?    2.2   0.1     0.095   4.3e+02       1      17 [.     214     230 ..     214     236 .. 0.77
  10 !    6.5   0.0    0.0037        16       1      12 [.     238     249 ..     238     259 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.2
       LRR_1  2 LrhLdLsnnpl..lgl 15
                  +L  sn+ l  +g 
  EFC37772.1 18 IIELSFSNQTLtqSGV 33
                4567777777744444 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.015
       LRR_1  2 LrhLdLsnnpllglppnsfq 21
                L +Ld+s++ +++ ++n++ 
  EFC37772.1 47 LITLDISYQKIGDAGSNTIG 66
                889********999999886 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.012
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++L++++n +++ ++ s+ 
  EFC37772.1 70 KLTKLYVCGNEISSEGAKSIG 90
                79**********998888876 PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.31
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++L ++ n+l++ ++ s+ 
  EFC37772.1  94 NLTYLSVRINHLGSEGAKSIG 114
                 899**9999999888887775 PP

  == domain 5  score: 9.4 bits;  conditional E-value: 0.00041
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +Lr+L++ +n++++ ++ s++ 
  EFC37772.1 118 KLRTLYIAHNQIGDEGIKSISQ 139
                 7***********9999999876 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 2.6
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L++L+  +n++++ ++ s+
  EFC37772.1 143 LTTLYTDYNQIGSGGAKSI 161
                 7788888899877777665 PP

  == domain 7  score: 1.7 bits;  conditional E-value: 0.14
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L++L +s n++++ ++ s+ 
  EFC37772.1 167 LTELGISENNIEDEGAKSIG 186
                 99999******999999886 PP

  == domain 8  score: 5.0 bits;  conditional E-value: 0.011
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 Lr+L  s++++++ +++s+++L
  EFC37772.1 191 LRKLSASRCRIGDEGAESISKL 212
                 99****************9987 PP

  == domain 9  score: 2.2 bits;  conditional E-value: 0.095
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL++L ++ np+ + ++
  EFC37772.1 214 NLTKLSINTNPIKDEGA 230
                 8**********965555 PP

  == domain 10  score: 6.5 bits;  conditional E-value: 0.0037
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld++++++
  EFC37772.1 238 QLKKLDITRCSI 249
                 59********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       274  (0.0152825); expected 358.6 (0.02)
Passed bias filter:                      188  (0.0104858); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.33s 00:00:00.87 Elapsed: 00:00:00.54
# Mc/sec: 1501.75
//
Query:       EFC37773.1  [L=351]
Description: hypothetical protein NAEGRDRAFT_53469 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.1e-40  138.0   0.5    3.9e-40  137.7   0.5    1.1  1  Rad1      Repair protein Rad1/Rec1/Rad17
  ------ inclusion threshold ------
      0.011   15.9   1.8      0.057   13.6   0.0    2.4  3  PCNA_C    Proliferating cell nuclear antigen, C-terminal doma
      0.037   13.1   0.5       0.69    9.0   0.1    2.3  2  Hus1      Hus1-like protein


Domain annotation for each model (and alignments):
>> Rad1  Repair protein Rad1/Rec1/Rad17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.7   0.5   6.5e-44   3.9e-40       2     275 .]      64     324 ..      63     324 .. 0.93

  Alignments for each domain:
  == domain 1  score: 137.7 bits;  conditional E-value: 6.5e-44
        Rad1   2 fsAtlsnvseLatlLksiafkdk.....alvqissdGlkfivednrvlqaqafldkalFtsYtfenaqddedeedeeedsvsfevsLsallecLnifgk 95 
                 ++A   +++ +a+++++i+  +k     ++++i+++G+kf+ +d +++q++a +++++F++Y +         +     + sfe++++ l++cL + g 
  EFC37773.1  64 MVADIASAKIFANIMHCICSDKKkedawVICEIMEEGIKFYIQD-KSIQGVASMKRDIFQNYIY---------NGAAHAKYSFEINVQILIQCLILYGA 152
                 7899999*************996689999*************87.689****************.........55567899****************** PP

        Rad1  96 ndssskessssraskvasssakatscklsYkgeGsPLvliLeeagvtttcelsTyepeedldleldrqevvlkvilkselLhsalteLdatskklkila 194
                 n+s+                   t +kl+Y g  + L+l+L e+ v+t c+++     e ld+e++ +e + k++lkse++++al+e+d  +k+++i +
  EFC37773.1 153 NSSQG------------------TIVKLCYPGVENTLSLLLGEERVVTDCNIKIRHGAEPLDFEFKGSEETCKIVLKSEVMTDALSEIDWLAKTMEIGV 233
                 *9987..................59************************************************************************** PP

        Rad1 195 ssekk............apvfalsak.gelgssevefpneksvlekfevsslsessessYkfallkkaakalalssKvslrmdeaGlLslqfmi 275
                 +   +            +  + +++    +gs  + +p++++ + +fev+   +++ s++k++++++a kal  s  v++rm+e+GlL  qfm+
  EFC37773.1 234 EMDVQeqgedqvaitlpKGKLFFKTVdNVIGSMDIIIPSTNEGVCSFEVN---HTQMSVFKLSHIQQALKALPHSDRVCIRMNEQGLLQWQFMV 324
                 998886666666666555599999996778********************...999999**********************************6 PP

>> PCNA_C  Proliferating cell nuclear antigen, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.2     0.083   4.9e+02      20      46 ..      80     106 ..      57     122 .. 0.73
   2 ?   -3.3   0.0       1.6   9.3e+03      33      63 ..     187     217 ..     183     223 .. 0.68
   3 ?   13.6   0.0   9.6e-06     0.057      29     117 ..     242     326 ..     233     335 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.083
                 HHHHHHTTT-SEEEEEEETTEEEEEEE CS
      PCNA_C  20 ricrdlsqlsdsvvisvtkegvkfsas 46 
                  ic d  + +  v+  +  eg+kf  +
  EFC37773.1  80 CICSDKKKEDAWVICEIMEEGIKFYIQ 106
                 478888888888999999*****9765 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.6
                 EEEEETTEEEEEEEETTEEEEEEE--BEESS CS
      PCNA_C  33 visvtkegvkfsasGdiGsasivlkqvkdvd 63 
                  i    e + f  +G   + +ivlk  ++ d
  EFC37773.1 187 KIRHGAEPLDFEFKGSEETCKIVLKSEVMTD 217
                 5555666777777777777777777776655 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 9.6e-06
                 -SEEEEEEETTEEEEEEEET.TEEEEEEE--BEESSSGGGCBEEEESS-EEEEEEHHHHHHHGGGGGC-SEEEEEEETTSEEEEEEEETT CS
      PCNA_C  29 sdsvvisvtkegvkfsasGd.iGsasivlkqvkdvdkeeeavklelkepvtltfalkYlaeftkatsLservtlslssevPlvveykikd 117
                 +d+v i++ k  + f++  + iGs +i++        +e     e++++    f l ++++  ka + s+rv +++ ++  l  ++ ++ 
  EFC37773.1 242 EDQVAITLPKGKLFFKTVDNvIGSMDIIIPS-----TNEGVCSFEVNHTQMSVFKLSHIQQALKALPHSDRVCIRMNEQGLLQWQFMVRA 326
                 6889999999999998755437888888765.....56889999********************************99988888888765 PP

>> Hus1  Hus1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.1   0.00012      0.69      27      99 ..      92     162 ..      64     195 .. 0.79
   2 ?    2.3   0.1     0.013        76      70     102 ..     282     315 ..     235     341 .. 0.59

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00012
        Hus1  27 cilrltpeklrfiiiteaddgvqvwaqlqvdaiFeeyeieSndeneInlevdlaaLlraLks..aeaaksvqlrL 99 
                 +i+ + +e + f i+   d+ +q +a++++d iF++y+ ++++  + ++e++++ L++ L    a+++++  ++L
  EFC37773.1  92 VICEIMEEGIKFYIQ---DKSIQGVASMKRD-IFQNYIYNGAAHAKYSFEINVQILIQCLILygANSSQGTIVKL 162
                 788999999999999...7889999999988.***********9**************77440044444666666 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.013
        Hus1  70 eneInlev.dlaaLlraLksaeaaksvqlrLtkk 102
                  n+ +++v +l++  +aLk   ++ +v +r+  +
  EFC37773.1 282 VNHTQMSVfKLSHIQQALKALPHSDRVCIRMNEQ 315
                 2333334444555666666666666666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       506  (0.0282224); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 2311.84
//
Query:       EFC37774.1  [L=891]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.12   12.6   0.2       0.12   12.6   0.2    6.1  5  Med21         Subunit 21 of Mediator complex
        4.7    7.1  28.8       0.12   12.2   4.6    4.6  5  LemA          LemA family


Domain annotation for each model (and alignments):
>> Med21  Subunit 21 of Mediator complex
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.9      0.52   4.7e+03     128     128 ..     175     175 ..     103     238 .. 0.69
   2 ?   -0.5   0.3      0.15   1.3e+03      57      78 ..     387     408 ..     309     443 .. 0.59
   3 ?   12.6   0.2   1.3e-05      0.12      82     130 ..     496     544 ..     468     561 .. 0.74
   4 ?   -3.8   4.7       1.6   1.4e+04      69      86 ..     634     651 ..     583     685 .. 0.56
   5 ?  -13.0  26.6         2   1.8e+04      22     142 ..     641     785 ..     608     787 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.52
       Med21 128 k 128
                 k
  EFC37774.1 175 K 175
                 0 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.15
       Med21  57 keepepdspeefaatqrelard 78 
                 + + e++++eef++++r la d
  EFC37774.1 387 NCQLENEKREEFEEQVRRLAPD 408
                 2344556667777777776655 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 1.3e-05
       Med21  82 keqqIeyLIssLPgigsseeeqeerikeLeeelreveeereekvkekee 130
                 ++  I   +++LP+++   +eq+e+ik+Le+  +e     e  +++k +
  EFC37774.1 496 RSTLITHVVNKLPEVNRHIDEQLEHIKQLETPPKEEVVVEETPIQKKHQ 544
                 4567999**********************98555444444444444433 PP

  == domain 4  score: -3.8 bits;  conditional E-value: 1.6
       Med21  69 aatqrelardlilkeqqI 86 
                 ++++ +l+ +li + q++
  EFC37774.1 634 DKQMSTLSIKLIDQDQKM 651
                 333333333333333332 PP

  == domain 5  score: -13.0 bits;  conditional E-value: 2
       Med21  22 tlgylntshdpsplseqdpsspsaapalakip...............................qeekeepepdspeefaatqrelardlilkeqqIeyL 89 
                 +++++++++++ ++ e+ +s  +        +                               +++ ++  ++ ++++ +t ++ a+   +  ++Ie L
  EFC37774.1 641 SIKLIDQDQKMREIREKANSAETL-------SleldqarkelqsmkdlrikqgndevrhlatlNDQLQQAVKQLQTKLTSTEEQAAQSKKMFNKKIEEL 732
                 444555555554444433333333.......03333334667778888888887777777777444444444444455555555555555556788888 PP

       Med21  90 IssLPgigsseeeqeerikeLeeelreveeereekvkekeellkkveellrav 142
                  +s  + ++++  q++ i+ L++ l+  +++++++ + k +l +++e+l +++
  EFC37774.1 733 QASIDNSSETSVIQLKVIATLKDSLESEKKKLKKAEQDKATLKTELEKLKEQI 785
                 8888888889999********************************99998887 PP

>> LemA  LemA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.5      0.24   2.1e+03      81     103 ..     152     174 ..      95     220 .. 0.70
   2 ?   -1.2   0.2      0.19   1.7e+03      20      54 ..     194     228 ..     184     243 .. 0.74
   3 ?    6.9   5.2   0.00057       5.1      11     137 ..     495     625 ..     487     638 .. 0.87
   4 ?   12.2   4.6   1.4e-05      0.12      80     125 ..     701     746 ..     649     769 .. 0.77
   5 ?   -0.7   0.2      0.13   1.1e+03      78     100 ..     766     788 ..     747     796 .. 0.58

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.24
        LemA  81 enfleLqeelegtEnriavaRrr 103
                 e+f+e+q++ ++ ++ i+  R+ 
  EFC37774.1 152 EEFREFQKKFSSADDIIQLMRST 174
                 56777777777777777777764 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.19
        LemA  20 vetvkgyakhEketleevteaRakaaeaesveeka 54 
                  e+v    k Ek +l++v +  +k+++ ++ ee +
  EFC37774.1 194 YEVVIECLKIEKYILKAVKSSEEKVQTIQKSEESE 228
                 67888889999999999999999985555555443 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.00057
        LemA  11 rRaDlipnLvetvkgyakhEketleevteaRakaaeaesvee..kaeaenqlssalsrllavaEnYPd.LkanenfleLqeelegtEnriavaRrrYne 106
                  R+ li+ +v+    + +h +e le++ ++ +  +e+  vee   +++++++s+  s l+a a n P  +k++ +  eL +e+ ++ n++  +R+ + +
  EFC37774.1 495 TRSTLITHVVNKLPEVNRHIDEQLEHIKQLETPPKEEVVVEEtpIQKKHQEISEFYSGLMAAAANIPTcIKTKGREVELEAEILKLRNELDSHRNLFES 593
                 689999***********************999998877776622589999*****************86899*************************** PP

        LemA 107 avreyntkiesfpsnivaklfgfke.kelfea 137
                    +++++ +s+ +++  k++ +++ ++ +e+
  EFC37774.1 594 LKYQLKEEQRSYQEQLNSKTIAYNKiEKDYEL 625
                 **********9999999999888775556666 PP

  == domain 4  score: 12.2 bits;  conditional E-value: 1.4e-05
        LemA  80 nenfleLqeelegtEnriavaRrrYneavreyntkiesfpsnivak 125
                 ++ +++Lq++l++tE++ a +++ +n++++e++++i++  ++ v +
  EFC37774.1 701 QQAVKQLQTKLTSTEEQAAQSKKMFNKKIEELQASIDNSSETSVIQ 746
                 6899******************************998876665555 PP

  == domain 5  score: -0.7 bits;  conditional E-value: 0.13
        LemA  78 kanenfleLqeelegtEnriava 100
                 ka++  ++L++ele++ ++i  +
  EFC37774.1 766 KAEQDKATLKTELEKLKEQIMKE 788
                 45555556666666666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (891 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3346  (0.186625); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                       137  (0.00764125); expected 17.9 (0.001)
Passed Fwd filter:                        64  (0.00356964); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.73u 0.37s 00:00:02.10 Elapsed: 00:00:00.64
# Mc/sec: 4205.80
//
Query:       EFC37775.1  [L=407]
Description: hypothetical protein NAEGRDRAFT_74454 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-19   69.5  46.5    4.1e-08   32.9   4.7    6.3  5  LRR_8       Leucine rich repeat
    2.2e-17   61.5  44.1     0.0037   17.2   0.1   12.2 12  LRR_6       Leucine Rich repeat
      8e-11   42.0  67.4     0.0008   19.8   0.4    8.6 10  LRR_4       Leucine Rich repeats (2 copies)
    4.6e-08   32.8   0.3    1.9e-07   30.8   0.3    2.1  1  F-box       F-box domain
    1.9e-06   27.7   0.4    4.3e-06   26.5   0.4    1.6  1  F-box-like  F-box-like
    0.00018   21.6  55.5       0.29   11.8   0.6   12.2 13  LRR_1       Leucine Rich Repeat
  ------ inclusion threshold ------
        1.4    8.4  16.1       0.71    9.4   3.5    3.8  5  LRR_9       Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.4      0.01        26      24      42 ..      65      83 ..      59      90 .. 0.81
   2 !   18.3   3.5   5.6e-07    0.0014       3      58 ..      68     128 ..      67     131 .. 0.83
   3 !   27.4   2.1     8e-10   2.1e-06       1      61 []     148     209 ..     145     209 .. 0.98
   4 ?    4.4  11.8     0.013        33       2      59 ..     225     284 ..     224     285 .. 0.88
   5 !   32.9   4.7   1.6e-11   4.1e-08       1      61 []     300     362 ..     300     362 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.01
                -TT--EEE--SS---GGGG CS
       LRR_8 24 lsnLkvLdLsnNllttlsp 42
                + ++k+L+Ls N l+t + 
  EFC37775.1 65 MLQVKSLSLSKNHLNTKHV 83
                5578999999999999775 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 5.6e-07
                 -SEEE-TTS--S..EE-TTSSTT.-TT--EEE--SS---G..GGGGGGTT--S-.EEE--S CS
       LRR_8   3 LtsLdLsnNrlt..slddeaFkg.lsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsg 58 
                 ++sL+Ls+N+l+  +++    ++ l+n   LdLs+N++ t  l ++++ +L +Lr L+L++
  EFC37775.1  68 VKSLSLSKNHLNtkHVEMIICSKyLQNISDLDLSYNNIGTdyLCRRMMKCLGNLRALNLRY 128
                 7899*****976115555555555**************999999***************86 PP

  == domain 3  score: 27.4 bits;  conditional E-value: 8e-10
                 TT-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nLtsLdLs  r ++ + e  ++ l++L++L+L+   ++ +  + + +L++L+sLdLs N++
  EFC37775.1 148 SNLTSLDLSYERVEEHGAEYISNnLKKLQILKLRGCFIQDVGVKHICNLEQLTSLDLSFNNI 209
                 69*******************999************************************97 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.013
                 T-SEEE-TTS-.-SEE-.TTSSTT..-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNr.ltsld.deaFkg..lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 nL++Ld+snN  +++l  +  F+g   +nL++L++s   ++  +   +++L++Lr+L+Ls +
  EFC37775.1 225 NLKTLDISNNFlFSHLAlPLLFSGenGKNLTSLNMSGLYISMGN--ELVSLNNLRELNLSKC 284
                 9**********9999985666766669**********9999885..*************976 PP

  == domain 5  score: 32.9 bits;  conditional E-value: 1.6e-11
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGT..T--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafs..gLpsLrsLdLsgNrL 61 
                 ++Lt+L++++N + +++    ++++nLk+L++s+N++t   +  +s  +Lp+L+ L L+gN++
  EFC37775.1 300 SKLTILNIDCNMIGNVNLNKLQKCKNLKELNISRNNITCSGAYELSqfDLPNLTTLILDGNDI 362
                 58*************************************98888864479***********97 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.1      0.06   1.5e+02       5      16 ..      68      79 ..      65      84 .. 0.88
   2 !    8.7   0.3   0.00079         2       4      17 ..      94     107 ..      91     108 .. 0.82
   3 ?    1.4   0.0      0.16   4.2e+02       4      16 ..     120     132 ..     120     133 .. 0.85
   4 ?    4.2   0.5     0.022        56       3      12 ..     148     157 ..     146     157 .. 0.87
   5 !   11.1   0.0   0.00013      0.34       3      24 .]     173     194 ..     171     194 .. 0.93
   6 !   17.2   0.1   1.4e-06    0.0037       5      21 ..     199     215 ..     195     218 .. 0.87
   7 ?    4.3   0.2      0.02        51       4      13 ..     225     234 ..     223     234 .. 0.91
   8 ?    1.7   0.0      0.13   3.4e+02       4      12 ..     253     261 ..     250     264 .. 0.88
   9 !    5.6   0.4    0.0074        19       3      14 ..     274     285 ..     272     288 .. 0.85
  10 ?    4.8   0.3     0.013        34       3      17 ..     300     314 ..     299     315 .. 0.89
  11 !   15.7   0.1   4.5e-06     0.011       1      23 [.     322     344 ..     322     345 .. 0.90
  12 !    7.7   0.1    0.0016       4.1       3      22 ..     350     369 ..     348     371 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.06
       LRR_6  5 LteLdLsgNdIg 16
                +++L+Ls N+++
  EFC37775.1 68 VKSLSLSKNHLN 79
                69*******997 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00079
       LRR_6   4 hLteLdLsgNdIgD 17 
                 ++  LdLs+N+Ig 
  EFC37775.1  94 NISDLDLSYNNIGT 107
                 6678********97 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.16
       LRR_6   4 hLteLdLsgNdIg 16 
                 +L++L+L++ ++g
  EFC37775.1 120 NLRALNLRYSGFG 132
                 69******98877 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.022
       LRR_6   3 thLteLdLsg 12 
                 ++Lt+LdLs+
  EFC37775.1 148 SNLTSLDLSY 157
                 89******96 PP

  == domain 5  score: 11.1 bits;  conditional E-value: 0.00013
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +L+ L L+g+ I+D+G++ ++
  EFC37775.1 173 KKLQILKLRGCFIQDVGVKHIC 194
                 589*****************98 PP

  == domain 6  score: 17.2 bits;  conditional E-value: 1.4e-06
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt+LdLs+N+Ig eG+ 
  EFC37775.1 199 LTSLDLSFNNIGREGCA 215
                 9*************986 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.02
       LRR_6   4 hLteLdLsgN 13 
                 +L++Ld+s N
  EFC37775.1 225 NLKTLDISNN 234
                 8*******99 PP

  == domain 8  score: 1.7 bits;  conditional E-value: 0.13
       LRR_6   4 hLteLdLsg 12 
                 +Lt+L++sg
  EFC37775.1 253 NLTSLNMSG 261
                 8******97 PP

  == domain 9  score: 5.6 bits;  conditional E-value: 0.0074
       LRR_6   3 thLteLdLsgNd 14 
                 ++L+eL+Ls ++
  EFC37775.1 274 NNLRELNLSKCK 285
                 79*******997 PP

  == domain 10  score: 4.8 bits;  conditional E-value: 0.013
       LRR_6   3 thLteLdLsgNdIgD 17 
                 ++Lt L++ +N Ig+
  EFC37775.1 300 SKLTILNIDCNMIGN 314
                 79*********9997 PP

  == domain 11  score: 15.7 bits;  conditional E-value: 4.5e-06
       LRR_6   1 snthLteLdLsgNdIgDeGaeaL 23 
                 ++ +L+eL++s N+I+ +Ga  L
  EFC37775.1 322 KCKNLKELNISRNNITCSGAYEL 344
                 5899************9999877 PP

  == domain 12  score: 7.7 bits;  conditional E-value: 0.0016
       LRR_6   3 thLteLdLsgNdIgDeGaea 22 
                 ++Lt+L L gNdI+  G+ +
  EFC37775.1 350 PNLTTLILDGNDIQYYGILS 369
                 79***********9777665 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   2.6    0.0067        17       4      34 ..      69     104 ..      67     110 .. 0.77
   2 !    7.7   1.1    0.0019       4.9       2      32 ..     120     157 ..     119     164 .. 0.70
   3 !   19.8   0.4   3.1e-07    0.0008       1      34 [.     173     208 ..     173     213 .. 0.88
   4 !   19.1   5.0     5e-07    0.0013       2      36 ..     198     236 ..     197     244 .. 0.80
   5 !    9.9   4.3   0.00038      0.98       1      32 [.     224     261 ..     224     268 .. 0.76
   6 ?    4.4   7.5     0.021        53       1      33 [.     252     284 ..     252     301 .. 0.70
   7 !    6.0  10.5    0.0067        17       2      43 ..     275     318 ..     274     322 .. 0.72
   8 !   17.9   7.0   1.2e-06    0.0031       2      36 ..     301     336 ..     300     346 .. 0.89
   9 !   19.1   5.0   5.1e-07    0.0013       1      39 [.     324     362 ..     324     373 .. 0.86
  10 !    7.7   2.5    0.0019       4.9       1      33 [.     350     386 ..     350     390 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0067
                 -EEE--SS---.E-S-...HHH.-TT--EEE-.-S- CS
       LRR_4   4 evLdLsnNqlt.dipl...lek.lpnLkeLdLsgNn 34 
                 ++L+Ls N+l  +      ++k l n   LdLs Nn
  EFC37775.1  69 KSLSLSKNHLNtKHVEmiiCSKyLQNISDLDLSYNN 104
                 789***99*99554447655577*********9994 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0019
                 S--EEE--SS-....--E-S-HH..H.-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNq....ltdiplle..k.lpnLkeLdLsg 32 
                 nL+ L+L+       l ++++++  + l nL++LdLs 
  EFC37775.1 120 NLRALNLRYSGfggiLIKLDGFSsnStLSNLTSLDLSY 157
                 777888885235555445778555555*********75 PP

  == domain 3  score: 19.8 bits;  conditional E-value: 3.1e-07
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNn 34 
                 ++L++L L+++ ++d++    + +l +L++LdLs+Nn
  EFC37775.1 173 KKLQILKLRGCFIQDVGVkhiC-NLEQLTSLDLSFNN 208
                 69****************8744.6*********9994 PP

  == domain 4  score: 19.1 bits;  conditional E-value: 5e-07
                 S--EEE--SS---E-S-.HH...H.-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.le...k.lpnLkeLdLsgNnli 36 
                 +L++LdLs N++   +  +    k ++nLk+Ld+s+N ++
  EFC37775.1 198 QLTSLDLSFNNIGREGCaFIsngKlMKNLKTLDISNN-FL 236
                 79***********755573357999*********666.54 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00038
                 SS--EEE--SS---E-S-HH........H-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdiplle........klpnLkeLdLsg 32 
                 +nL++Ld+snN l +   l+        + +nL++L++sg
  EFC37775.1 224 KNLKTLDISNNFLFS--HLAlpllfsgeNGKNLTSLNMSG 261
                 69********98665..4333344557779*******987 PP

  == domain 6  score: 4.4 bits;  conditional E-value: 0.021
                 SS--EEE--SS---E-S-HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsgN 33 
                 +nL++L+ s+  ++  + l +l nL+eL+Ls +
  EFC37775.1 252 KNLTSLNMSGLYISMGNELVSLNNLRELNLSKC 284
                 699999999844663333667*********998 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.0067
                 S--EEE--SS-.......--E-S-HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4   2 nLevLdLsnNq.......ltdiplleklpnLkeLdLsgNnlitdldeLk 43 
                 nL++L+Ls ++       l + +l   l +L+ L++ ++n i+++ +L+
  EFC37775.1 275 NLRELNLSKCKsmgclnrLNSCDL---LSKLTILNI-DCNMIGNV-NLN 318
                 9*******9644444111444444...999******.99999998.454 PP

  == domain 8  score: 17.9 bits;  conditional E-value: 1.2e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L++  N++  ++l  l+k++nLkeL++s+Nn i
  EFC37775.1 301 KLTILNIDCNMIGNVNLnkLQKCKNLKELNISRNN-I 336
                 8*******99***99999999************93.3 PP

  == domain 9  score: 19.1 bits;  conditional E-value: 5.1e-07
                 SS--EEE--SS---E-S-..HH..H-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..klpnLkeLdLsgNnlitdl 39 
                 +nL++L++s N++t  +   l+   lpnL++L L gN    d+
  EFC37775.1 324 KNLKELNISRNNITCSGAyeLSqfDLPNLTTLILDGN----DI 362
                 79************98886733677*******99999....77 PP

  == domain 10  score: 7.7 bits;  conditional E-value: 0.0019
                 SS--EEE--SS---E-S-HH....H.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdiplle....k.lpnLkeLdLsgN 33 
                 pnL++L L +N ++  + l+    k lpn k+L Ls N
  EFC37775.1 350 PNLTTLILDGNDIQYYGILSilnsKtLPNPKQL-LSKN 386
                 8*************999966666966*******.9998 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   0.3   7.3e-11   1.9e-07       2      44 ..       2      45 ..       1      48 [. 0.94

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 7.3e-11
                HHHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHHHH CS
       F-box  2 tlsrLPsevlrhILerLplsd.llalrrVSkgwrilidsdrlwc 44
                 l++LP+e +  I+++L++s+ ll +++VS +w i+  ++ l+ 
  EFC37775.1  2 QLDDLPDENISFIFQYLNTSTiLLQCSLVSHRWLIIASEVDLHV 45
                689**********************************9999985 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.5   0.4   1.7e-09   4.3e-06       2      36 ..       4      39 ..       3      43 .. 0.88

  Alignments for each domain:
  == domain 1  score: 26.5 bits;  conditional E-value: 1.7e-09
  F-box-like  2 srLPdEiLlqIFsyLpps.dLlrlalVCrrWrrval 36
                ++LPdE ++ IF+yL++s  Ll+++lV+ rW  +a+
  EFC37775.1  4 DDLPDENISFIFQYLNTStILLQCSLVSHRWLIIAS 39
                78*************98845999********99985 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       4.3   1.1e+04       8      22 ..      48      59 ..      43      63 .. 0.60
   2 ?    0.8   0.1      0.48   1.2e+03       3      14 ..      69      80 ..      67      93 .. 0.81
   3 ?    1.0   0.1      0.42   1.1e+03       5      12 ..      98     105 ..      92     112 .. 0.83
   4 ?    3.6   0.1     0.056   1.4e+02       1      16 [.     120     135 ..     120     146 .. 0.77
   5 ?    2.6   0.1      0.12   3.2e+02       1      11 [.     149     159 ..     149     172 .. 0.76
   6 !    7.4   0.1    0.0032       8.1       1      23 []     174     196 ..     174     196 .. 0.94
   7 !    6.3   0.1    0.0075        19       1      15 [.     198     212 ..     198     219 .. 0.78
   8 !   11.8   0.6   0.00011      0.29       1      15 [.     225     239 ..     225     247 .. 0.84
   9 ?    0.5   0.0      0.61   1.6e+03       1       9 [.     253     261 ..     253     269 .. 0.86
  10 ?    5.7   1.9     0.011        29       1      12 [.     275     286 ..     275     300 .. 0.77
  11 ?    1.2   0.5      0.34   8.8e+02       1      22 [.     301     322 ..     301     323 .. 0.74
  12 !   10.5   0.2   0.00032      0.82       1      17 [.     325     341 ..     325     347 .. 0.84
  13 ?    1.5   0.2      0.29   7.3e+02       1      12 [.     351     362 ..     351     384 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 4.3
       LRR_1  8 snnpllglppnsfqn 22
                 nn+     +n+f +
  EFC37775.1 48 QNNFR---KANCFLS 59
                55554...3566655 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.48
       LRR_1  3 rhLdLsnnpllg 14
                ++L Ls n+l  
  EFC37775.1 69 KSLSLSKNHLNT 80
                89******9944 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.42
       LRR_1   5 LdLsnnpl 12 
                 LdLs+n++
  EFC37775.1  98 LDLSYNNI 105
                 9*****98 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.056
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 nLr L+L++  ++g++
  EFC37775.1 120 NLRALNLRYSGFGGIL 135
                 8*******99985554 PP

  == domain 5  score: 2.6 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnp 11 
                 nL++LdLs+ +
  EFC37775.1 149 NLTSLDLSYER 159
                 8******9865 PP

  == domain 6  score: 7.4 bits;  conditional E-value: 0.0032
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L+ L L+++++ + +  +++nL
  EFC37775.1 174 KLQILKLRGCFIQDVGVKHICNL 196
                 7***********99999999987 PP

  == domain 7  score: 6.3 bits;  conditional E-value: 0.0075
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++LdLs n++++ 
  EFC37775.1 198 QLTSLDLSFNNIGRE 212
                 599********9654 PP

  == domain 8  score: 11.8 bits;  conditional E-value: 0.00011
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL++Ld+snn+l++ 
  EFC37775.1 225 NLKTLDISNNFLFSH 239
                 8**********9754 PP

  == domain 9  score: 0.5 bits;  conditional E-value: 0.61
       LRR_1   1 nLrhLdLsn 9  
                 nL++L++s+
  EFC37775.1 253 NLTSLNMSG 261
                 8*****997 PP

  == domain 10  score: 5.7 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpl 12 
                 nLr+L+Ls +  
  EFC37775.1 275 NLRELNLSKCKS 286
                 8*********86 PP

  == domain 11  score: 1.2 bits;  conditional E-value: 0.34
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L+ L++  n +++   n +q+
  EFC37775.1 301 KLTILNIDCNMIGNVNLNKLQK 322
                 79*****999886665565555 PP

  == domain 12  score: 10.5 bits;  conditional E-value: 0.00032
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL++L++s+n++++ ++
  EFC37775.1 325 NLKELNISRNNITCSGA 341
                 8***********98765 PP

  == domain 13  score: 1.5 bits;  conditional E-value: 0.29
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L L +n +
  EFC37775.1 351 NLTTLILDGNDI 362
                 8*********97 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.2      0.44   1.1e+03      84     123 ..      62     100 ..      43     129 .. 0.57
   2 ?    1.5   0.3      0.07   1.8e+02      62     148 ..      91     181 ..      62     187 .. 0.63
   3 ?    4.4   0.0    0.0093        24      56     124 ..     137     208 ..     132     216 .. 0.78
   4 ?    2.8   0.5     0.028        71      40      77 ..     195     237 ..     183     289 .. 0.67
   5 ?    9.4   3.5   0.00028      0.71      55     107 ..     315     369 ..     277     390 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.44
       LRR_9  84 eevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                 ++ + ++++l l++n+l+   +++ ++  k l+++s l+ 
  EFC37775.1  62 DDQMLQVKSLSLSKNHLNT-KHVEMIICSKYLQNISDLDL 100
                 5555556666666666654.33455555555555554443 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.07
       LRR_9  62 llkrlktlllnnnrivr..iaegleevlPnleelvltnnelq.eladldPlaslkklellsllknpvtn.kkeyrlyviyklkqlrlldfr 148
                 +l+ +  l l+ n i    +   + ++l nl++l l  + +   l +ld + s + l++l+ l+ +  + +++  +y+ + lk+l++l  r
  EFC37775.1  91 YLQNISDLDLSYNNIGTdyLCRRMMKCLGNLRALNLRYSGFGgILIKLDGFSSNSTLSNLTSLDLSYERvEEHGAEYISNNLKKLQILKLR 181
                 5555555555555553222556666777777777777666541456677766666666666665555441456678888888888888765 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.0093
       LRR_9  56 kldgfP...llkrlktlllnnnrivri.aegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                 kldgf     l  l +l l+ +r+    ae +++ l +l+ l l +  +q+++  + + +l++l++l l  n 
  EFC37775.1 137 KLDGFSsnsTLSNLTSLDLSYERVEEHgAEYISNNLKKLQILKLRGCFIQDVGV-KHICNLEQLTSLDLSFNN 208
                 778875222588889999999999755167799999999999999999999875.888999999988876665 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.028
       LRR_9  40 tldqfdtidlsdndirk.....ldgfPllkrlktlllnnnriv 77 
                  l+q+ ++dls n+i +     + +  l+k lktl ++nn + 
  EFC37775.1 195 NLEQLTSLDLSFNNIGRegcafISNGKLMKNLKTLDISNNFLF 237
                 578999999999999653444467788999*****99999764 PP

  == domain 5  score: 9.4 bits;  conditional E-value: 0.00028
       LRR_9  55 rkldgfPllkrlktlllnnnriv.riaegleev.lPnleelvltnnelqeladld 107
                  +l+ +   k lk l ++ n i+   a +l+++ lPnl++l+l +n +q  + l 
  EFC37775.1 315 VNLNKLQKCKNLKELNISRNNITcSGAYELSQFdLPNLTTLILDGNDIQYYGILS 369
                 3566777788899999988888614567898866999999999999999776554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       573  (0.0319594); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.64u 0.26s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 2573.54
//
Query:       EFC37776.1  [L=265]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-27   92.7  14.8    2.4e-05   24.0   0.0    8.2  9  LRR_6            Leucine Rich repeat
    5.5e-25   87.0  15.1    6.1e-05   23.3   0.1    5.4  5  LRR_4            Leucine Rich repeats (2 copies)
    3.1e-24   84.5   8.3    2.1e-09   37.0   0.6    4.2  4  LRR_8            Leucine rich repeat
    1.3e-08   34.2   7.2        5.1    8.0   0.1    8.1  8  LRR_1            Leucine Rich Repeat
    3.4e-06   26.7   6.9     0.0041   16.6   0.4    3.5  3  LRR_9            Leucine-rich repeat
  ------ inclusion threshold ------
      0.023   14.8   0.0      0.064   13.4   0.0    1.7  1  VirE_N           VirE N-terminal domain
       0.46   10.2   5.8        1.4    8.7   0.5    3.1  3  Ribosomal_L12_N  Ribosomal protein L7/L12 dimerisation domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.1   1.1e-07   0.00027       5      23 ..       4      22 ..       2      23 .. 0.93
   2 !    6.0   0.0    0.0056        14       4      24 .]      27      47 ..      24      47 .. 0.88
   3 !   24.0   0.0   9.4e-09   2.4e-05       5      24 .]      52      71 ..      49      71 .. 0.93
   4 ?    2.8   0.0     0.061   1.6e+02       5      23 ..      77      95 ..      76      96 .. 0.87
   5 ?    5.1   0.0     0.011        28       5      23 ..     125     143 ..     121     144 .. 0.77
   6 ?   -3.0   0.0       4.5   1.1e+04       7      16 ..     151     160 ..     149     161 .. 0.77
   7 !   15.7   0.0   4.3e-06     0.011       4      23 ..     172     191 ..     169     192 .. 0.89
   8 !   21.4   0.1   6.7e-08   0.00017       5      24 .]     197     216 ..     194     216 .. 0.95
   9 ?   -1.8   0.0       1.8   4.5e+03       3      15 ..     219     231 ..     217     231 .. 0.75

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 1.1e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+Ld+s+N IgD Ga+ +
  EFC37776.1  4 LTALDISSNRIGDGGAMLI 22
                9***************987 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0056
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                +L +L++  N++g  Ga++++
  EFC37776.1 27 NLITLQIYENHLGPNGAKSIS 47
                688999999*********996 PP

  == domain 3  score: 24.0 bits;  conditional E-value: 9.4e-09
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt Ld+s+N I DeG+++++
  EFC37776.1 52 LTILDISHNRIRDEGVKSIS 71
                9****************996 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.061
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt Ld+s+ +I+ +G+  L
  EFC37776.1 77 LTNLDISFVGISEKGLVPL 95
                99******99999998877 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.011
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 +teLd+s+N  ++e ++++
  EFC37776.1 125 ITELDISYNLTNNEILKSI 143
                 79*******7666666665 PP

  == domain 6  score: -3.0 bits;  conditional E-value: 4.5
       LRR_6   7 eLdLsgNdIg 16 
                 +L L  N+I+
  EFC37776.1 151 KLYLVKNGIT 160
                 5788899998 PP

  == domain 7  score: 15.7 bits;  conditional E-value: 4.3e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L++s N+I +eG+  +
  EFC37776.1 172 QLTVLNISENEIRNEGVVYI 191
                 59***************877 PP

  == domain 8  score: 21.4 bits;  conditional E-value: 6.7e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 LteLd+s N+Ig eG+ +++
  EFC37776.1 197 LTELDISNNGIGYEGVLSIC 216
                 9*****************98 PP

  == domain 9  score: -1.8 bits;  conditional E-value: 1.8
       LRR_6   3 thLteLdLsgNdI 15 
                 t Lt+L++  N I
  EFC37776.1 219 TQLTKLSIYNNPI 231
                 6799999877765 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.9e-06    0.0075       1      34 [.       2      41 ..       2      51 .. 0.75
   2 !   20.4   0.0   1.9e-07   0.00048       1      32 [.      50      84 ..      50      89 .. 0.87
   3 !   12.5   0.3   5.8e-05      0.15       1      38 [.      99     136 ..      99     144 .. 0.80
   4 !   21.8   0.5   7.1e-08   0.00018       1      36 [.     147     183 ..     147     187 .. 0.87
   5 !   23.3   0.1   2.4e-08   6.1e-05       1      36 [.     195     231 ..     195     240 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.9e-06
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S....- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN....n 34
                ++L+ Ld+s+N++ d +   +++l+nL +L + +N    n
  EFC37776.1  2 KQLTALDISSNRIGDGGAmlIGGLKNLITLQIYENhlgpN 41
                589************88894446*********88844444 PP

  == domain 2  score: 20.4 bits;  conditional E-value: 1.9e-07
                SS--EEE--SS---E-S-...HHH-TT--EEE-.- CS
       LRR_4  1 pnLevLdLsnNqltdipl...leklpnLkeLdLsg 32
                ++L++Ld+s+N+++d +     ek+++L+ Ld+s+
  EFC37776.1 50 KQLTILDISHNRIRDEGVksiSEKMDQLTNLDISF 84
                58*************999885558*********76 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 5.8e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +nL++L + ++ql++ +   ++k+++ +eLd+s N  +t+
  EFC37776.1  99 KNLKILAFYDCQLSTKQAetISKMKQITELDISYN--LTN 136
                 69************655557668*********998..544 PP

  == domain 4  score: 21.8 bits;  conditional E-value: 7.1e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+L  N +t+ +   +++l++L++L++s+N  i
  EFC37776.1 147 KQLIKLYLVKNGITSHQVeiISQLKQLTVLNISEN-EI 183
                 58*************99986557*********999.44 PP

  == domain 5  score: 23.3 bits;  conditional E-value: 2.4e-08
                 SS--EEE--SS---E-S-HH..H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdiplle..klpnLkeLdLsgNnli 36 
                 ++L++Ld+snN +   + l+  k+++L++L++  Nn+i
  EFC37776.1 195 KQLTELDISNNGIGYEGVLSicKMTQLTKLSI-YNNPI 231
                 58************777777879*********.77777 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.0   0.3   1.5e-11   3.8e-08       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   15.2   0.0   5.2e-06     0.013       2      59 ..      76     133 ..      75     134 .. 0.95
   3 !   37.0   0.6   8.4e-13   2.1e-09       2      61 .]     148     207 ..     147     207 .. 0.96
   4 ?    1.5   0.0       0.1   2.6e+02      24      38 ..     218     232 ..     214     249 .. 0.59

  Alignments for each domain:
  == domain 1  score: 33.0 bits;  conditional E-value: 1.5e-11
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +Lt Ld+s+Nr+ + +     gl+nL +L++ +N l    ++++s L++L+ Ld+s+Nr+
  EFC37776.1  3 QLTALDISSNRIGDGGAMLIGGLKNLITLQIYENHLGPNGAKSISELKQLTILDISHNRI 62
                79********************************************************98 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 5.2e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+Ld+s+  +++ +      ++nLk+L   + +l+t  ++++s ++++++Ld+s+N
  EFC37776.1  76 QLTNLDISFVGISEKGLVPLVEMKNLKILAFYDCQLSTKQAETISKMKQITELDISYN 133
                 6999999999999999999999***********************************9 PP

  == domain 3  score: 37.0 bits;  conditional E-value: 8.4e-13
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L +L+L +N +ts + e  ++l++L+vL++s+N+++      +sgL++L++Ld+s+N +
  EFC37776.1 148 QLIKLYLVKNGITSHQVEIISQLKQLTVLNISENEIRNEGVVYISGLKQLTELDISNNGI 207
                 5779******************************************************86 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.1
                 -TT--EEE--SS--- CS
       LRR_8  24 lsnLkvLdLsnNllt 38 
                 +++L+ L++ nN + 
  EFC37776.1 218 MTQLTKLSIYNNPIP 232
                 556666666666655 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0     0.012        31       2      15 ..       4      17 ..       3      49 .. 0.77
   2 !    8.0   0.1     0.002       5.1       1      21 [.      51      71 ..      51      85 .. 0.82
   3 ?    1.1   0.0      0.39   9.9e+02       1      22 [.     100     121 ..     100     122 .. 0.87
   4 ?    1.4   0.0      0.29   7.5e+02       3      11 ..     126     134 ..     124     146 .. 0.73
   5 ?   -1.4   0.0       2.5   6.3e+03       2      16 ..     149     163 ..     148     170 .. 0.71
   6 ?    2.7   0.0      0.11   2.9e+02       1      13 [.     172     184 ..     172     194 .. 0.76
   7 !    7.2   0.0    0.0039        10       1      16 [.     196     211 ..     196     218 .. 0.72
   8 ?    3.0   0.0     0.093   2.4e+02       2      13 ..     221     232 ..     220     249 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.012
       LRR_1  2 LrhLdLsnnpllgl 15
                L+ Ld+s+n++++ 
  EFC37776.1  4 LTALDISSNRIGDG 17
                899*******9443 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.002
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L+ Ld+s+n++ + +  s++
  EFC37776.1 51 QLTILDISHNRIRDEGVKSIS 71
                599********9777766664 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.39
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL+ L   +++l+ ++++++++
  EFC37776.1 100 NLKILAFYDCQLSTKQAETISK 121
                 89999999****9999998876 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.29
       LRR_1   3 rhLdLsnnp 11 
                 ++Ld+s+n 
  EFC37776.1 126 TELDISYNL 134
                 789998884 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 2.5
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L +L+L  n +++ +
  EFC37776.1 149 LIKLYLVKNGITSHQ 163
                 889999888876555 PP

  == domain 6  score: 2.7 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++L++s n + 
  EFC37776.1 172 QLTVLNISENEIR 184
                 599*****99874 PP

  == domain 7  score: 7.2 bits;  conditional E-value: 0.0039
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++Ld+snn ++  +
  EFC37776.1 196 QLTELDISNNGIGYEG 211
                 599*******985444 PP

  == domain 8  score: 3.0 bits;  conditional E-value: 0.093
       LRR_1   2 LrhLdLsnnpll 13 
                 L++L + nnp++
  EFC37776.1 221 LTKLSIYNNPIP 232
                 99********83 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0   0.00048       1.2      63     148 ..       1      83 [.       1      91 [. 0.83
   2 !   16.6   0.4   1.6e-06    0.0041      62     146 ..      48     129 ..      41     138 .. 0.85
   3 !    9.6   0.7   0.00023      0.58      56     127 ..     163     233 ..     146     249 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00048
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldfr 148
                 +k+l +l +++nri   +  l   l nl +l + +n+l   +  + + +lk+l++l + +n + +  e  + +  k++ql+ ld  
  EFC37776.1   1 MKQLTALDISSNRIGDGGAMLIGGLKNLITLQIYENHLGPNGA-KSISELKQLTILDISHNRIRD--EGVKSISEKMDQLTNLDIS 83 
                 688999********************************99887.899999999999999998854..4456677788888777765 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 1.6e-06
       LRR_9  62 llkrlktlllnnnrivria.egleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                  lk+l +l ++ nri+  + + ++e + +l++l ++   + e + l Pl+++k+l++l++ ++ +++k+      i k+kq++ ld
  EFC37776.1  48 ELKQLTILDISHNRIRDEGvKSISEKMDQLTNLDISFVGISEKG-LVPLVEMKNLKILAFYDCQLSTKQA---ETISKMKQITELD 129
                 58999**********97653678899999999999888898865.79*******************9985...5788999988887 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00023
       LRR_9  56 kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 +++ +  lk+l +l +++n i++ +      l +l+el ++nn +   + +  + ++ +l+ ls+ +np+ +
  EFC37776.1 163 QVEIISQLKQLTVLNISENEIRNEGVVYISGLKQLTELDISNNGIGYEG-VLSICKMTQLTKLSIYNNPIPE 233
                 5667778999999999999999888888888999999999999998655.5678999999999999999865 PP

>> VirE_N  VirE N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   2.5e-05     0.064      19      76 ..      41      99 ..      34     135 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.5e-05
      VirE_N 19 rkekklkkynglvvlDidhlask.eeaeelrrllkedpqtllaFvspsgrGvKifvrie 76
                +++k++ ++ +l +lDi h   + e ++++ +++ ++ ++ ++Fv++s++G+  +v ++
  EFC37776.1 41 NGAKSISELKQLTILDISHNRIRdEGVKSISEKMDQLTNLDISFVGISEKGLVPLVEMK 99
                78999************997755157999**********************97777666 PP

>> Ribosomal_L12_N  Ribosomal protein L7/L12 dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.034        88       6      18 ..      46      58 ..      43      59 .. 0.89
   2 ?   -1.5   0.1      0.82   2.1e+03       1      12 [.     135     146 ..     135     149 .. 0.87
   3 ?    8.7   0.5   0.00054       1.4       4      19 ..     165     180 ..     163     180 .. 0.93

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.034
                     HHHHHTSBHHHHH CS
  Ribosomal_L12_N  6 ieaikeltvLEls 18
                     i ++k+lt+L++s
       EFC37776.1 46 ISELKQLTILDIS 58
                     789*******997 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.82
                      HHHHHHHHHHTS CS
  Ribosomal_L12_N   1 kieeiieaikel 12 
                      +++ei+++i e+
       EFC37776.1 135 TNNEILKSIGEM 146
                      6789*****999 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00054
                      HHHHHHHTSBHHHHHH CS
  Ribosomal_L12_N   4 eiieaikeltvLElse 19 
                      eii ++k+ltvL +se
       EFC37776.1 165 EIISQLKQLTVLNISE 180
                      8***********9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (265 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       877  (0.0489152); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 1715.68
//
Query:       EFC37777.1  [L=514]
Description: histone deacetylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-78  264.8   0.1    2.2e-78  263.8   0.0    1.6  2  Hist_deacetyl  Histone deacetylase domain
  ------ inclusion threshold ------
       0.16   12.5   3.4       0.76   10.4   0.4    2.5  2  Fer4_17        4Fe-4S dicluster domain


Domain annotation for each model (and alignments):
>> Hist_deacetyl  Histone deacetylase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0      0.66   5.9e+03      66     108 ..      86     128 ..      64     135 .. 0.62
   2 !  263.8   0.0   2.5e-82   2.2e-78       1     307 []     165     467 ..     165     467 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 0.66
                    CCHHHCCTSTSSSSSTHCTTTCCHHHHHHHHHHHHHHHHHHTT CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl  66 ekeleeiasklldddtpvspktlkaallavgavleavdavlsg 108
                    + +++ei+s    dd++++++  + + +  g+v   ++ +++g
     EFC37777.1  86 KVDMQEIESYFNMDDCILHQECGRKCMVMDGSVNPSISYIVTG 128
                    2334455544566778888888888877777777777777766 PP

  == domain 2  score: 263.8 bits;  conditional E-value: 2.5e-82
                    SCCGTHHHHHHHHHHHHT.THHHHCCE.EE-----HHHHTTTS-HHHHHHHHCHHHHCHHT.TTHCCHHHCCTSTSSSSSTHCTTTCCHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl   1 hpenpkRlsaileslaesvglldelelliqpseatkeellkvHskeYlelleslsnelkkkeeakekeleeiasklldddtpvspktlkaallavg 96 
                    hpe+p Rls i++  +e    +d+ +++i+ ++at+eel+  Hs+++++++  ++ e+ +                 ++d++v +++ +aa++a g
     EFC37777.1 165 HPESPARLSGIWSFAIEEF-HFDKGCTIIEGRKATREELEWTHSPHHVDAVMASHLEMFNF----------------STDVFVGEQSGDAARVASG 243
                    89*******9999888874.5899999************************9877665333................4689*************** PP

                    HHHHHHHHHHTTSSSEEEETTSS--TT-BTTB-BTTBSS-HHHHHHHHHHHCC-SS-EEEEE-SSS--HHHHHHCTT...............-TTE CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...............xxxx RF
  Hist_deacetyl  97 avleavdavlsgsvkaafvlvrPpgHHakaseasGFClvNnvaiaikylqakhelkrvailDvDvHhGnGteeafys...............dpdv 177
                    +++e + +v++g+++++f+++rPpgHH++ ++asGFC+vNnva+a+++l +++ +kr++i+D+DvHhGnGt++++++               +p++
     EFC37777.1 244 GLIEIATKVMNGEFDNGFAIIRPPGHHCYFDKASGFCIVNNVAVAANVLVKRSLAKRIVIVDWDVHHGNGTQAILEDqfkerfdncnpnndeKPEI 339
                    ***************************************************999**********************77777777777777778*** PP

                    EEEEEEE-CCTSTTSS--TT---SGGGTTSEEEEEE-TT-BHHHHHHHHHHCHHHHHCCH--SEEEEEE-STTBTTSTT-S-BB-HHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 178 ltlSiHryegifyPgtgaledlgegkgkgfnlnvpleegtgdeeylkvfeeilrpvleefkPdlilvsaGfDalkgdplgelnlsvegykeltkkl 273
                    +++S+H+++++fyP+tg+le++  + +k+f++n+p++e  gd+e+l++fe+i++p++++++Pd++lvsaGfDa+kgd+lg+  +s++ +++lt +l
     EFC37777.1 340 IFFSLHQTKNNFYPKTGTLEQIAYEGAKKFIFNIPFDETYGDQEILNAFEQIIMPIASNYNPDIVLVSAGFDAVKGDKLGGQLCSQQLFGHLTCML 435
                    **********************9999999******************************************************************* PP

                    CCCHGS-G.EEEEE-S---HHHHHHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 274 aeladkvkkvvllleGGYnlealaravtavlsal 307
                    ++la+  +k+vl leGGYn++++a +v++++s+l
     EFC37777.1 436 KTLAN--GKIVLALEGGYNIQETAGCVKECVSVL 467
                    ****9..59*******************999875 PP

>> Fer4_17  4Fe-4S dicluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.4   8.5e-05      0.76      28      56 ..      84     111 ..      62     113 .. 0.75
   2 ?    2.2   0.2      0.03   2.7e+02       7      32 ..     458     487 ..     454     505 .. 0.56

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 8.5e-05
     Fer4_17  28 aaklglleeaekeekaslCieCgeCerkC 56 
                 ++k+ +++e+e   ++++Ci  +eC rkC
  EFC37777.1  84 KYKV-DMQEIESYFNMDDCILHQECGRKC 111
                 3333.456666678*************** PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.03
     Fer4_17   7 yClpeCpsyeaydnepk...kllraakl..g 32 
                  C++eC s  + ++ p+   +l + ++l  +
  EFC37777.1 458 GCVKECVSVLCGQE-PQglsSLFQTMYLkeE 487
                 6******9988444.5512244444444221 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       846  (0.0471861); expected 358.6 (0.02)
Passed bias filter:                      545  (0.0303977); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.48
# Mc/sec: 3197.85
//
Query:       EFC37778.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00014   22.3   2.0    0.00075   19.9   1.9    2.0  1  YkuD      L,D-transpeptidase catalytic domain


Domain annotation for each model (and alignments):
>> YkuD  L,D-transpeptidase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   1.9   4.2e-08   0.00075      37     139 ..     111     197 ..      16     204 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 4.2e-08
                 TSE---EEEEECEEEEEEE..EEGGGGT--TTSTT.EEEEEEEECCCTTCECCCCEEE-STTS-EEEE.ETCSS...CT...HHC.BSSSEEE-HHHHH CS
        YkuD  37 dreTPlGtfrikskvrnptwnvppsiarkeiypklrkdpeyldkknskvalgkvkfvfpngsgiyiHgtgapdlfergk...garrShGCirlseedak 132
                 d  TP+G ++ +                ++ +++ ++ p  ++++ + +  ++     +  sgi +H tg  +     k   +++ ShGCi+  ++d++
  EFC37778.1 111 DGDTPTGLYTFD--------------LNTPEDNPVEYGPYDVNRAVYGLKGNSLLIYPKYRSGILMH-TGEWNI----KpndPMPNSHGCIHAMPHDIQ 190
                 457888888887..............22222333334444444444444667788899999******.333332....23468888*******999999 PP

                 HHHHHHH CS
        YkuD 133 elyelvl 139
                  +++ ++
  EFC37778.1 191 LIANILK 197
                 9988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       428  (0.0238719); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1406.19
//
Query:       EFC37779.1  [L=659]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (659 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2233  (0.124547); expected 358.6 (0.02)
Passed bias filter:                      676  (0.0377043); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.88u 0.37s 00:00:01.25 Elapsed: 00:00:00.54
# Mc/sec: 3655.46
//
Query:       EFC37780.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1277  (0.0712254); expected 358.6 (0.02)
Passed bias filter:                      613  (0.0341904); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 1516.85
//
Query:       EFC37781.1  [L=969]
Description: hypothetical protein NAEGRDRAFT_74467 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (969 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.74u 0.31s 00:00:01.05 Elapsed: 00:00:00.48
# Mc/sec: 6038.70
//
Query:       EFC37782.1  [L=546]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-12   47.4   1.2    1.3e-11   44.7   1.2    2.3  1  C2        C2 domain
     0.0073   15.9   0.0      0.015   14.9   0.0    1.4  1  CEP76-C2  CEP76 C2 domain
  ------ inclusion threshold ------
      0.075   13.0   1.7        5.1    7.1   0.0    2.7  2  CIA30     Complex I intermediate-associated protein 30 (CIA30
        3.4    8.1   7.1        4.4    7.7   5.2    2.1  2  PBP1_TM   Transmembrane domain of transglycosylase PBP1 at N-
        9.4    6.2  12.9      0.076   13.1   1.7    2.8  3  DUF2076   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.7   1.2   3.6e-15   1.3e-11       5      91 ..     363     474 ..     360     486 .. 0.85

  Alignments for each domain:
  == domain 1  score: 44.7 bits;  conditional E-value: 3.6e-15
                 EEEEEEESSSSSST..TSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESC..................HTTSEEEEEEEEECSSSTEEEEEE CS
          C2   5 vtvieAknLpnkdk..kgssdpyvkvsldgkqkakTrviknslnPvWnekftfevae..................leeakLeveVfdndrlskddfiGk 83 
                 ++ ++++ ++n     k++s++y+++++ g+ ++ +rv+ ns nPvWn++f+f ++                   + + +++++++d+d +++++f+Gk
  EFC37782.1 363 LNLLKGQSIKNSGNgfKENSNVYAVIEV-GNYRKTSRVVMNSSNPVWNQQFQFILPTfyhpfvqdlkemhdantePINNVVTIRLYDHDEIFEHEFLGK 460
                 5667777776663346778*********.********998888**********9998999************99999********************** PP

                 EEEEGHH......H CS
          C2  84 veiplst......l 91 
                 ve++l++       
  EFC37782.1 461 VEFKLDElfvqccQ 474
                 *****995555433 PP

>> CEP76-C2  CEP76 C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   4.1e-06     0.015      34      97 ..     379     443 ..     360     462 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 4.1e-06
    CEP76-C2  34 qvestlrlhlefrkqRfrskpvpctcePefneeFlleleteeesasadaeaLlsl.sepihlvvi 97 
                 +++s ++  +e +++R +s+ v+ +++P  n +F + l+t  +++ +d +++ +   epi+ vv+
  EFC37782.1 379 KENSNVYAVIEVGNYRKTSRVVMNSSNPVWNQQFQFILPTFYHPFVQDLKEMHDAnTEPINNVVT 443
                 678899999********************************999999999998651578885553 PP

>> CIA30  Complex I intermediate-associated protein 30 (CIA30)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0    0.0014       5.1      10      46 ..     119     155 ..     109     182 .. 0.80
   2 ?    3.7   0.8     0.016        58      24      58 ..     296     329 ..     292     346 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0014
       CIA30  10 dkwtllsDrvmGGvStaslklskkdktalFsGnlste 46 
                 +++++l+D+ ++GvS a++++s  ++tal   ++s e
  EFC37782.1 119 NSIQSLTDKHVEGVSAAHVNMSMLTNTALTPRKISDE 155
                 5599*****************9878888766666655 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.016
       CIA30  24 StaslklskkdktalFsGnlstelinrgGFasvrt 58 
                 S++s++ + k+++++F+ nl  e+ +++GF ++  
  EFC37782.1 296 SSVSVQTR-KSQGGQFQTNLAREASSSSGFSNFSD 329
                 77888885.799*******************9987 PP

>> PBP1_TM  Transmembrane domain of transglycosylase PBP1 at N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   5.2    0.0012       4.4      23      68 ..      56      99 ..      48     106 .. 0.58
   2 ?   -1.7   0.0         1   3.8e+03      48      73 ..     156     181 ..     150     186 .. 0.62

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0012
     PBP1_TM 23 kkasrrrrrdddyddeyddeedDdddddeeeevprkgkkkkpprkk 68
                +k++ ++r + d ++  ++e+dDd +++e++  +r  +++ +p+k+
  EFC37782.1 56 SKPTNKKRVNHDEEE--QYESDDDYEEQENQGNSRVLHRSTQPKKR 99
                344444444444344..56667766666777777776666667776 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1
     PBP1_TM  48 dddeeeevprkgkkkkpprkkrrwlw 73 
                  ++ ++  p+  ++ ++ rkk+++l+
  EFC37782.1 156 SEEHSKGYPKTPNTPASARKKKSLLS 181
                 33444445777777777888887775 PP

>> DUF2076  Uncharacterized protein conserved in bacteria (DUF2076)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   1.7   2.1e-05     0.076      77     140 ..      28      98 ..      11     148 .. 0.74
   2 ?   -1.1   0.1      0.44   1.6e+03      84     118 ..     173     209 ..     151     247 .. 0.62
   3 ?   -0.5   0.7      0.29   1.1e+03     193     239 ..     267     320 ..     246     343 .. 0.47

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.1e-05
     DUF2076  77 qaqeaqaqpssggFLsg.lFGggkke.rpqpspqarpaapagqalgqeeqyaaqpgyaq.....qqaqpqy 140
                 +++ +q++++ ggF+ + +FG+ +++ +++p  ++r +   ++++++ + y++q+++++     +++qp++
  EFC37782.1  28 SEEPSQQHEPTGGFFYNlFFGNSSNNnYSKPTNKKRVNHDEEEQYESDDDYEEQENQGNsrvlhRSTQPKK 98 
                 45556677779******455666666766666666666666777777777777776666667765556654 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.44
     DUF2076  84 qpssggFLsglFGggkke..rpqpspqarpaapagqa 118
                 +++  + Ls++F   + +   ++p+ +++p+  ++++
  EFC37782.1 173 ARKKKSLLSSIFSFSSAAnsDSPPPLPSTPSSATTPQ 209
                 3345788999777666664333333333333332222 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.29
     DUF2076 193 sqsaeeeeiinnyy...............ssssladdaedadnasadsfadsdsssdnnada 239
                  ++++++  inn++               s      +++ ++ +s+  + +++  +++  ++
  EFC37782.1 267 YGNQQIVSQINNQTsemppagcrnsfdceS------SVSVQTRKSQGGQFQTNLAREA--SS 320
                 456677788888887777777774444330......3333332222222221111111..11 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (546 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1440  (0.0803168); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.75u 0.28s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 3098.48
//
Query:       EFC37783.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.9e-16   58.2   1.3    2.7e-05   24.0   0.0    3.9  3  NHL             NHL repeat
    4.4e-07   30.1   1.3    1.5e-06   28.4   0.1    2.4  3  BTB             BTB/POZ domain
    0.00063   19.8   0.5          3    7.7   0.0    3.3  4  Phytase-like    Esterase-like activity of phytase
     0.0036   17.6   0.4        7.2    7.1   0.0    3.5  3  Linker_histone  linker histone H1 and H5 family
  ------ inclusion threshold ------
      0.022   14.3  11.3        1.5    8.4   0.4    3.8  3  Plasmo_rep      Plasmodium repeat family
      0.053   13.9   0.2       0.19   12.2   0.2    1.9  1  YtzH            YtzH-like protein
      0.055   13.2   0.4        2.1    8.0   0.0    3.1  3  PCMT            Protein-L-isoaspartate(D-aspartate) O-methylt
       0.13   12.3   1.3       0.59   10.3   1.3    2.2  1  SBDS            Shwachman-Bodian-Diamond syndrome (SBDS) prot


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   1.2e-08   2.7e-05       1      27 [.      10      36 ..      10      37 .. 0.96
   2 !   19.1   0.0   4.1e-07   0.00091       2      27 ..      67      92 ..      66      93 .. 0.89
   3 !   11.8   0.0     9e-05       0.2       2      23 ..     123     144 ..     122     149 .. 0.84

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 1.2e-08
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +nyP++v v+sn+++y+aD +n+r+++
  EFC37783.1 10 LNYPRCVFVSSNNEVYIADEGNQRIRK 36
                79***********************86 PP

  == domain 2  score: 19.1 bits;  conditional E-value: 4.1e-07
                SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  2 nyPhGvavdsnGdiyVaDsenhrvqv 27
                ++P G+ v+sn+++y++Ds+n+r+++
  EFC37783.1 67 YNPFGIFVSSNNEVYISDSGNNRIRK 92
                67778999****************86 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 9e-05
                 SSEEEEEEETTTEEEEEECCCT CS
         NHL   2 nyPhGvavdsnGdiyVaDsenh 23 
                 ++P G+ v+ n+++y++Ds+n+
  EFC37783.1 123 YNPFGIFVSANNEVYISDSNNN 144
                 677788899***********98 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.88     2e+03      59      94 ..     237     273 ..     217     290 .. 0.66
   2 ?   -2.9   0.0       3.5   7.8e+03      78      97 ..     300     319 ..     291     330 .. 0.67
   3 !   28.4   0.1   6.6e-10   1.5e-06       4      44 ..     388     428 ..     385     440 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.88
                 SGHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHHHHH CS
         BTB  59 vepeafealLefiYtgeleit.seenleelLaaadll 94 
                  + e++++l++ +  ++ +++ s+e++ ++L +  l+
  EFC37783.1 237 SQQEIIQKLIDSLMYDKNKVNfSKEEILDVLFILGLF 273
                 4556777777765444444444788888888776665 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.5
                 C-CGGGHHHHHHHH.HHHT-H CS
         BTB  78 itseenleelLaaa.dllqip 97 
                 ++ +e++e+lL++  + ++++
  EFC37783.1 300 FK-WETIENLLKVCkEEFNVQ 319
                 43.667777776665555555 PP

  == domain 3  score: 28.4 bits;  conditional E-value: 6.6e-10
                 HHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST CS
         BTB   4 lresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk 44 
                 l +    +Dv +++g++k +++hk vL+++S++F+alf+s+
  EFC37783.1 388 LYNDMNTSDVKIKMGQNKYLYCHKTVLSSSSTFFNALFESG 428
                 55566789*******************************98 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0035       7.9      75     100 ..      18      43 ..      16      50 .. 0.89
   2 !    7.7   0.0    0.0013         3      56     101 ..      55     100 ..      42     104 .. 0.78
   3 ?    2.3   0.0     0.059   1.3e+02      54     100 ..     109     155 ..     100     159 .. 0.78
   4 ?   -4.0   0.0       5.1   1.1e+04     117     131 ..     286     300 ..     276     301 .. 0.69

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0035
  Phytase-like  75 vapdgtfwvssEggpfilefdadGkl 100
                   v++++++++++Eg+ +i+++  +G++
    EFC37783.1  18 VSSNNEVYIADEGNQRIRKVVENGNI 43 
                   47899****************99987 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0013
  Phytase-like  56 kdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdadGkll 101
                     ++g +   + ++p gi v++++++++s+ g+++i+++  +G+++
    EFC37783.1  55 SGDNGPATSAQLYNPFGIFVSSNNEVYISDSGNNRIRKVLENGNII 100
                   55555444445557779*************************9985 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.059
  Phytase-like  54 plkdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdadGkl 100
                    +  ++g +   + ++p gi v++++++++s+  ++ i+++  +G++
    EFC37783.1 109 GFSGDNGPATSAQLYNPFGIFVSANNEVYISDSNNNIIRKILENGNI 155
                   5555555555445557789**********************999987 PP

  == domain 4  score: -4.0 bits;  conditional E-value: 5.1
  Phytase-like 117 daglrrnrGfEglal 131
                   +++ +++ ++Egl++
    EFC37783.1 286 TSEFENSLTLEGLTF 300
                   466778888888875 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.0    0.0032       7.2      47      69 ..      31      53 ..      16      56 .. 0.83
   2 ?    2.4   0.0     0.094   2.1e+02      47      69 ..      87     109 ..      73     113 .. 0.77
   3 ?    4.0   0.0     0.029        65      46      69 ..     142     165 ..     129     168 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0032
  Linker_histone 47 kkalkkgvekgelvqpkgkGasG 69
                    ++ ++k ve+g +v + g+G++G
      EFC37783.1 31 NQRIRKVVENGNIVTIAGNGTAG 53
                    899***************99988 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.094
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k +e+g ++ + g+G+ G
      EFC37783.1  87 NNRIRKVLENGNIITIAGNGTVG 109
                     7899************9977654 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.029
  Linker_histone  46 lkkalkkgvekgelvqpkgkGasG 69 
                      ++ ++k +e+g +v + g+G+ G
      EFC37783.1 142 NNNIIRKILENGNIVTIAGNGTRG 165
                     47889**************99887 PP

>> Plasmo_rep  Plasmodium repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.2    0.0021       4.7       1      13 [.      19      30 ..      19      32 .. 0.81
   2 ?    8.4   0.4   0.00069       1.5       1      10 [.      75      84 ..      75      87 .. 0.91
   3 ?    4.3   0.9     0.013        29       3      10 ..     133     140 ..     131     144 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0021
  Plasmo_rep  1 FsDnEvYspkqEi 13
                +s+nEvY+ + E+
  EFC37783.1 19 SSNNEVYIAD-EG 30
                69*****988.65 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00069
  Plasmo_rep  1 FsDnEvYspk 10
                +s+nEvY+++
  EFC37783.1 75 SSNNEVYISD 84
                6*******98 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.013
  Plasmo_rep   3 DnEvYspk 10 
                 +nEvY+++
  EFC37783.1 133 NNEVYISD 140
                 9*****98 PP

>> YtzH  YtzH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.2   8.3e-05      0.19      11      43 ..     222     254 ..     220     274 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 8.3e-05
        YtzH  11 kDiLkeqqadccgtvseceQierlvksllanee 43 
                 + iLk+++  c ++ s+ e i++l+ sl+ +++
  EFC37783.1 222 CNILKNEKILCLMSSSQQEIIQKLIDSLMYDKN 254
                 67***************************8765 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.23   5.3e+02     100     138 ..      16      55 ..       5      61 .. 0.78
   2 ?    0.6   0.0      0.18     4e+02      95     138 ..      67     111 ..      52     116 .. 0.76
   3 ?    8.0   0.0   0.00095       2.1     111     145 ..     138     174 ..     111     183 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.23
                 EEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT 100 rvvsierikelveeakrnlkkldle.nvivvvgDGrkGye 138
                   vs +    +++e +++++k   + n++++ g G+ G+ 
  EFC37783.1  16 VFVSSNNEVYIADEGNQRIRKVVENgNIVTIAGNGTAGFS 55 
                 456666666678888999999877779***********96 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.18
                 HCTTCEEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES-GGGTTG CS
        PCMT  95 vgekgrvvsierikelveeakrnlkkldle.nvivvvgDGrkGye 138
                  ++ g  vs +    + ++ +++++k   + n+i++ g G+ G+ 
  EFC37783.1  67 YNPFGIFVSSNNEVYISDSGNNRIRKVLENgNIITIAGNGTVGFS 111
                 5555666666666777788889998865556************96 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.00095
                 HHHHHHHHHHCTTC..SEEEEES-GGGTTGGG-SEEE CS
        PCMT 111 veeakrnlkkldle..nvivvvgDGrkGyeekaPYda 145
                 ++++++n+ ++ le  n++++ g G+ G+   +P+d 
  EFC37783.1 138 ISDSNNNIIRKILEngNIVTIAGNGTRGFSGDSPFDI 174
                 34567777666666679******************95 PP

>> SBDS  Shwachman-Bodian-Diamond syndrome (SBDS) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   1.3   0.00026      0.59      14      80 ..      70     155 ..      15     161 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00026
                 EEEEE.-HHHHHHHHCTT---HHHHBSSSS-EEETTTT........EE--HHHHHHHH...........S---HHHHHHHHHHHSEE CS
        SBDS  14 Feiav.yknklleyregkeidLsevlqsekiFtnaskG........etaskselekaf...........gteskdeiikeILkkGei 80 
                 F i+v + n+++   +g +  + +vl++ +i t a  G          a  ++l + f            ++s+++ii++IL++G+i
  EFC37783.1  70 FGIFVsSNNEVYISDSG-NNRIRKVLENGNIITIAGNGtvgfsgdnGPATSAQLYNPFgifvsannevyISDSNNNIIRKILENGNI 155
                 88899555555555555.7889999999999999999999999999999999999999777766666655555789*********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       678  (0.0378158); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2719.13
//
Query:       EFC37784.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   2.6e-109  356.8  31.7      2e-16   59.4   0.1    9.0  9  DUF4116       Domain of unknown function (DUF4116)
      5e-05   23.0   1.1       0.71    9.4   0.0    3.5  3  Ac81          Baculoviridae AC81
     0.0007   19.6   0.2       0.66   10.1   0.0    4.0  4  DUF1667       Protein of unknown function (DUF1667)
  ------ inclusion threshold ------
      0.022   15.3   2.5         14    6.3   0.0    4.2  5  CbiG_C        Cobalamin synthesis G C-terminus
       0.11   12.6   1.0         25    5.1   0.0    3.5  3  Cupredoxin_1  Cupredoxin-like domain
       0.91    9.2   8.1        1.8    8.2   1.3    3.4  2  N6_N4_Mtase   DNA methylase
        2.4    8.3  16.6       0.22   11.6   0.5    5.0  7  MotCF         Bacteriophage T4 MotA, C-terminal


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   7.3e-06     0.019      22      49 .]      74     102 ..      73     102 .. 0.94
   2 !   57.9   0.1   2.3e-19   5.9e-16       1      49 []     104     152 ..     104     152 .. 0.99
   3 !   57.2   0.1   3.8e-19   9.7e-16       1      43 [.     129     171 ..     129     173 .. 0.97
   4 !   52.1   0.0   1.5e-17   3.9e-14       1      48 [.     154     199 ..     154     200 .. 0.97
   5 !   50.0   0.2   6.7e-17   1.7e-13       1      49 []     202     250 ..     202     250 .. 0.99
   6 !   59.4   0.1   7.9e-20     2e-16       1      49 []     252     301 ..     252     301 .. 0.98
   7 !   49.3   0.3   1.1e-16   2.8e-13       1      49 []     303     351 ..     303     351 .. 0.99
   8 !   58.1   0.3     2e-19   5.2e-16       1      44 [.     353     396 ..     353     398 .. 0.98
   9 !   30.7   0.7   7.6e-11   1.9e-07       1      32 [.     402     433 ..     402     433 .. 0.98

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 7.3e-06
     DUF4116  22 eLknDkeivlkAvkqng.talsyaseeLr 49 
                 +L n+k iv+ +vk+n+ t+++ as+eL+
  EFC37784.1  74 NLWNNKFIVMMIVKINPtTVFENASKELK 102
                 689**************779*******97 PP

  == domain 2  score: 57.9 bits;  conditional E-value: 2.3e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivleav  n+++lkyls +L +D+ i++kA+++ng al+yas+eL+
  EFC37784.1 104 DREIVLEAVGCNPCVLKYLSYDLISDRAIIMKAMQINGLALKYASKELQ 152
                 9**********************************************97 PP

  == domain 3  score: 57.2 bits;  conditional E-value: 3.8e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 Dr i+++a+++ng+alky+s+eL+nD+eivl Avk+ngt+l+y
  EFC37784.1 129 DRAIIMKAMQINGLALKYASKELQNDREIVLLAVKNNGTSLNY 171
                 899***************************************9 PP

  == domain 4  score: 52.1 bits;  conditional E-value: 1.5e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrEivl avk+ng +l+y   +++nD+ei ++Avk+ng al+y+s++L
  EFC37784.1 154 DREIVLLAVKNNGTSLNY--TNIRNDREIEMEAVKKNGLALEYVSHHL 199
                 9*****************..67***********************998 PP

  == domain 5  score: 50.0 bits;  conditional E-value: 6.7e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eivl a+ ++ +a+ y+s e++nD+e+vl+ vk++  ++ +as+eLr
  EFC37784.1 202 DKEIVLTAINQDLNAFIYASIEIQNDRELVLELVKKSAWIFQFASKELR 250
                 9***********************************************8 PP

  == domain 6  score: 59.4 bits;  conditional E-value: 7.9e-20
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+ea+k+n  ++++++s+eL+nD++++l A+kq+ + l+yasee+r
  EFC37784.1 252 DREIVTEAIKRNaYCVYRHVSKELRNDRQLALIAIKQHASLLEYASEEIR 301
                 9***********779*********************************98 PP

  == domain 7  score: 49.3 bits;  conditional E-value: 1.1e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+ea++++   l+ +s+ Lk+Dk ++l++v+qn+  l+y+s+eLr
  EFC37784.1 303 DREIVMEAIRRDEQTLEMASDQLKSDKSFLLEIVQQNSQMLEYFSDELR 351
                 9***********************************************8 PP

  == domain 8  score: 58.1 bits;  conditional E-value: 2e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 D+E++le+vkk  s +ky+s +L+nD+e++lkAvk ng +l+ya
  EFC37784.1 353 DKEFILELVKKSASTIKYASYNLRNDREFILKAVKLNGMVLKYA 396
                 9******************************************8 PP

  == domain 9  score: 30.7 bits;  conditional E-value: 7.6e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 DrEivle +k++ + ++y+s +Lk+D+e++l+
  EFC37784.1 402 DREIVLESIKQDINTYEYASRDLKKDREVLLE 433
                 9****************************986 PP

>> Ac81  Baculoviridae AC81
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0   0.00078         2      68     109 ..      89     130 ..      71     138 .. 0.90
   2 !    9.4   0.0   0.00028      0.71      49     113 ..     217     283 ..     197     290 .. 0.74
   3 ?    2.3   0.0     0.042   1.1e+02      76     119 ..     298     341 ..     288     350 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00078
        Ac81  68 qpktifttkdissdedaliikelvkcdyCvkeeleenvqkdn 109
                 +p t+f++   + ++d +i+ e v c+ Cv + l   + +d+
  EFC37784.1  89 NPTTVFENASKELKRDREIVLEAVGCNPCVLKYLSYDLISDR 130
                 7899**99999999999***************9988888776 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00028
        Ac81  49 Hyfaqidv.ndrdkelHPGsqpktift..tkdissdedaliikelvkcd.yCvkeeleenvqkdnnFni 113
                   +a i++ ndr+  l    +   if+  +k+++ d+  +i+ e +k++ yCv++++ + +++d++  +
  EFC37784.1 217 FIYASIEIqNDRELVLELVKKSAWIFQfaSKELRGDR--EIVTEAIKRNaYCVYRHVSKELRNDRQLAL 283
                 5577777777777777776666666551156666666..888888877659*************98766 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.042
        Ac81  76 kdissdedaliikelvkcdyCvkeeleenvqkdnnF..nilfnNCe 119
                  +i++d+  +i+ e + +d+   e+  + +++d++F  +i+ +N +
  EFC37784.1 298 EEIRNDR--EIVMEAIRRDEQTLEMASDQLKSDKSFllEIVQQNSQ 341
                 4677777..9**************************6668888887 PP

>> DUF1667  Protein of unknown function (DUF1667)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   0.00026      0.66       5      46 ..     145     186 ..     144     196 .. 0.92
   2 ?   -0.9   0.0      0.66   1.7e+03       5      24 ..     243     262 ..     242     272 .. 0.84
   3 ?    3.8   0.0     0.023        58       5      33 ..     294     322 ..     293     339 .. 0.87
   4 ?   -3.9   0.0         6   1.5e+04       5      27 ..     369     391 ..     368     396 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00026
     DUF1667   5 eYakkEvtnpkRivtstvkveggelplvpVktsepipkekif 46 
                 +Ya kE+ n + iv   vk +g +l+  +++ +++i+ e ++
  EFC37784.1 145 KYASKELQNDREIVLLAVKNNGTSLNYTNIRNDREIEMEAVK 186
                 7***********************************998876 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.66
     DUF1667   5 eYakkEvtnpkRivtstvkv 24 
                 ++a kE+   + ivt  +k 
  EFC37784.1 243 QFASKELRGDREIVTEAIKR 262
                 699***********988875 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.023
     DUF1667   5 eYakkEvtnpkRivtstvkveggelplvp 33 
                 eYa +E+ n + iv+  ++ ++++l++ +
  EFC37784.1 294 EYASEEIRNDREIVMEAIRRDEQTLEMAS 322
                 7*****************99998888765 PP

  == domain 4  score: -3.9 bits;  conditional E-value: 6
     DUF1667   5 eYakkEvtnpkRivtstvkvegg 27 
                 +Ya  ++ n +  +   vk++g 
  EFC37784.1 369 KYASYNLRNDREFILKAVKLNGM 391
                 68888888888888888887765 PP

>> CbiG_C  Cobalamin synthesis G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.99   2.5e+03      29      56 ..      88     115 ..      82     135 .. 0.76
   2 ?    6.3   0.0    0.0054        14      37      66 ..     219     248 ..     178     262 .. 0.83
   3 ?    5.1   0.1     0.013        34      25      67 ..     302     350 ..     285     371 .. 0.71
   4 ?   -2.2   0.0       2.3   5.9e+03      35      60 ..     368     393 ..     354     398 .. 0.72
   5 ?   -0.9   0.0      0.93   2.4e+03      36      51 ..     418     433 ..     399     435 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.99
                 --GGGEEEEEESSCCSHHHHHHHHHHHC CS
      CbiG_C  29 lseeavaalatidlKadepgllelaekl 56 
                 +++  v + a+ +lK+d + +le++   
  EFC37784.1  88 INPTTVFENASKELKRDREIVLEAVGCN 115
                 6677788889999999999999987655 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0054
                 EEESSCCSHHHHHHHHHHHCTSTEEEE-HH CS
      CbiG_C  37 latidlKadepgllelaeklglplktfsae 66 
                  a+i++++d + +lel++k  + +++ s+e
  EFC37784.1 219 YASIEIQNDRELVLELVKKSAWIFQFASKE 248
                 79**********************999887 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.013
                 HHCT--GGGEEE......EEESSCCSHHHHHHHHHHHCTSTEEEE-HHH CS
      CbiG_C  25 eeaglseeavaa......latidlKadepgllelaeklglplktfsaee 67 
                 ++ ++ +ea+++      +a+ +lK+d+  lle++++ +  l++fs e 
  EFC37784.1 302 NDREIVMEAIRRdeqtleMASDQLKSDKSFLLEIVQQNSQMLEYFSDEL 350
                 4444444444444444449******************998888888764 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 2.3
                 EEEEESSCCSHHHHHHHHHHHCTSTE CS
      CbiG_C  35 aalatidlKadepgllelaeklglpl 60 
                  + a+ +l++d + +l++++  g+ l
  EFC37784.1 368 IKYASYNLRNDREFILKAVKLNGMVL 393
                 45788899999999988888766655 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 0.93
                 EEEESSCCSHHHHHHH CS
      CbiG_C  36 alatidlKadepglle 51 
                 + a+ dlK+d + lle
  EFC37784.1 418 EYASRDLKKDREVLLE 433
                 57999*****999987 PP

>> Cupredoxin_1  Cupredoxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.1     0.016        40      10      71 ..     145     206 ..     137     212 .. 0.87
   2 ?    5.1   0.0    0.0097        25      16      71 ..     198     256 ..     190     263 .. 0.77
   3 ?    1.6   0.0      0.12     3e+02      32      69 ..     318     355 ..     277     374 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.016
  Cupredoxin_1  10 llsskaaaaaektveitvkdggfePskievkagekvklkiknkdktpeefesedlgeekvla 71 
                    ++sk+ +++++ v + vk++g + +  ++  +++++++ ++k   + e +s+ l+ +k++ 
    EFC37784.1 145 KYASKELQNDREIVLLAVKNNGTSLNYTNIRNDREIEMEAVKKNGLALEYVSHHLSNDKEIV 206
                   5567777999999**************************99999999999999999999885 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0097
  Cupredoxin_1  16 aaaaektveitvkdg...gfePskievkagekvklkiknkdktpeefesedlgeekvla 71 
                   + +++k++++t+ ++   +f  ++ie++ ++++ l++++k++   +f s++l+ + ++ 
    EFC37784.1 198 HLSNDKEIVLTAINQdlnAFIYASIEIQNDRELVLELVKKSAWIFQFASKELRGDREIV 256
                   4455555555544443558999*****************************99887775 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.12
  Cupredoxin_1  32 fePskievkagekvklkiknkdktpeefesedlgeekv 69 
                    e ++ ++k+++++ l+i+++ ++  e  s++l+ +k+
    EFC37784.1 318 LEMASDQLKSDKSFLLEIVQQNSQMLEYFSDELRNDKE 355
                   45555567888888889888888888888888887764 PP

>> N6_N4_Mtase  DNA methylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.8     0.039     1e+02      81     126 ..     130     177 ..      39     206 .. 0.69
   2 ?    8.2   1.3   0.00069       1.8      29     110 ..     308     387 ..     210     431 .. 0.71

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.039
                  EEEEEES...S.STTTSTCCS-B--EEEEEEEESSTT-..---GGGSSBS CS
  N6_N4_Mtase  81 vivwkkp...n.smpesnkdrltsthEyilvfsknkkyllkfnldaikvp 126
                  +++++k    n    ++++++l+++ E +l+ +kn  +  ++n++ i++ 
   EFC37784.1 130 RAIIMKAmqiNgLALKYASKELQNDREIVLLAVKNNGT--SLNYTNIRND 177
                  34444443442234455556888888888888888888..5555555544 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00069
                  HHHHHHHHHHHHHHHHHEEEEEEEEEEE-CCCHHTHHHHHHHHHTT.-EEEEEEEEEEESSSTTTSTCCS-B--EEEEEEEES CS
  N6_N4_Mtase  29 eeyleflekvlkevrrvLkddgsifiniddseikkelkaladeifg.gffllnvivwkkpnsmpesnkdrltsthEyilvfsk 110
                   e +++ e+ l+ + + Lk d+s+++ i +++ +  +++   +++  +  ++  +v+ k+ s+ ++++++l+++ E+il  +k
   EFC37784.1 308 MEAIRRDEQTLEMASDQLKSDKSFLLEIVQQNSQ--MLEYFSDELRnDKEFILELVK-KSASTIKYASYNLRNDREFILKAVK 387
                  4445555556666666666666666666666665..555555555555555555555.3346666666666666666666555 PP

>> MotCF  Bacteriophage T4 MotA, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       1.6     4e+03      62      71 ..      72      81 ..      44     121 .. 0.55
   2 ?    2.0   0.3     0.084   2.1e+02       4      44 ..     125     167 ..     122     182 .. 0.69
   3 ?    2.2   0.2     0.071   1.8e+02       5      39 ..     174     208 ..     170     228 .. 0.75
   4 ?   -0.6   0.0      0.55   1.4e+03       4      23 ..     223     242 ..     219     256 .. 0.85
   5 ?   -0.8   0.1      0.63   1.6e+03       4      18 ..     349     363 ..     321     370 .. 0.56
   6 ?   -1.0   0.0      0.73   1.9e+03       4      24 ..     349     369 ..     345     377 .. 0.81
   7 ?   11.6   0.5   8.6e-05      0.22       4      49 ..     374     419 ..     371     425 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.6
                --HHHHHHHH CS
       MotCF 62 mmehhiqkft 71
                m++   +kf 
  EFC37784.1 72 MLNLWNNKFI 81
                3333333332 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.084
                 HHHHHHHHHHHHHHHTT--EEEE..EEETTEEEEEEEEEETTE CS
       MotCF   4 dmeedkdlmlklldkngfvlkkv..eiyrsnylailekrtngi 44 
                 d+  d+ +++k ++ ng+ lk    e+     + +l  + ng 
  EFC37784.1 125 DLISDRAIIMKAMQINGLALKYAskELQNDREIVLLAVKNNGT 167
                 7788999999999999999996522566666667777777764 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.071
                 HHHHHHHHHHHHHHTT--EEEEEEETTEEEEEEEE CS
       MotCF   5 meedkdlmlklldkngfvlkkveiyrsnylailek 39 
                 + +d+++ ++ + kng+ l+ v  + sn   i+  
  EFC37784.1 174 IRNDREIEMEAVKKNGLALEYVSHHLSNDKEIVLT 208
                 67889999999999999999999988887766544 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 0.55
                 HHHHHHHHHHHHHHHTT--E CS
       MotCF   4 dmeedkdlmlklldkngfvl 23 
                 ++++d++l+l+l+ k  +++
  EFC37784.1 223 EIQNDRELVLELVKKSAWIF 242
                 57899********9998876 PP

  == domain 5  score: -0.8 bits;  conditional E-value: 0.63
                 HHHHHHHHHHHHHHH CS
       MotCF   4 dmeedkdlmlklldk 18 
                 ++ +dk+++l+l+ k
  EFC37784.1 349 ELRNDKEFILELVKK 363
                 344555555555555 PP

  == domain 6  score: -1.0 bits;  conditional E-value: 0.73
                 HHHHHHHHHHHHHHHTT--EE CS
       MotCF   4 dmeedkdlmlklldkngfvlk 24 
                 ++ +dk+++l+l+ k    +k
  EFC37784.1 349 ELRNDKEFILELVKKSASTIK 369
                 57899*******999887766 PP

  == domain 7  score: 11.6 bits;  conditional E-value: 8.6e-05
                 HHHHHHHHHHHHHHHTT--EEEEEEETTEEEEEEEEEETTEEEEEE CS
       MotCF   4 dmeedkdlmlklldkngfvlkkveiyrsnylailekrtngirnfei 49 
                 ++ +d++++lk +  ng+vlk   ++r +   +le   + i  +e 
  EFC37784.1 374 NLRNDREFILKAVKLNGMVLKYATLFRNDREIVLESIKQDINTYEY 419
                 5789*******************************99999998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       866  (0.0483016); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 2385.19
//
Query:       EFC37785.1  [L=434]
Description: hypothetical protein NAEGRDRAFT_59674 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.5e-14   51.9   0.0    3.1e-06   27.7   0.0    2.9  2  RCC1      Regulator of chromosome condensation (RCC1) repeat
    8.3e-13   47.8  10.0    0.00014   21.6   1.5    5.4  6  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   3.6e-08   0.00033       4      49 ..      44     114 ..      43     115 .. 0.69
   2 !   27.7   0.0   3.4e-10   3.1e-06       3      49 ..     120     168 ..     118     169 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 3.6e-08
                 EEEEE--GGGTTSS.....SS---E...........EEEEE-GGGTTS.........-EEEEEEETTEEEE CS
        RCC1   4 VysWGrndyGqLGl.....gttesv...........lvPtkveglsgn.........rvvkvacGddhtva 49 
                 ++s G+nd+GqLG+      +te+             +P+ +e   ++         ++++va+G +h ++
  EFC37785.1  44 LLSMGSNDKGQLGRnlfkeDDTETYpigpvlelyhkETPKSIEDEYERlemdsrilrDIKHVAAGRSHLLL 114
                 789***********7776522233344433333333459888665555666677899***********875 PP

  == domain 2  score: 27.7 bits;  conditional E-value: 3.4e-10
                 EEEEEE--GGGTTSSSS---EEEE..EE-GGGTTS.-EEEEEEETTEEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesvlvP..tkveglsgn.rvvkvacGddhtva 49 
                 ++y+ G+n+y qLG + +e+  +P  + ve++++   v  va+G++h++ 
  EFC37785.1 120 KIYAMGFNNYSQLGFKEEEQY-IPrlRPVELPEKVsSVDGVAAGWFHSII 168
                 69****************999.554444555665547777********86 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.3   0.0    0.0082        74      20      30 .]      44      54 ..      42      54 .. 0.92
   2 !   19.7   0.0     6e-08   0.00054       1      30 []     102     131 ..     102     131 .. 0.95
   3 !   21.6   1.5   1.5e-08   0.00014       4      30 .]     159     185 ..     153     185 .. 0.94
   4 ?   -0.9   0.1      0.18   1.6e+03      14      24 ..     224     234 ..     223     243 .. 0.77
   5 ?   -2.6   0.0       0.6   5.4e+03      12      21 ..     270     279 ..     270     280 .. 0.88
   6 !    4.1   0.0    0.0046        41       2      22 ..     344     364 ..     343     365 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.0082
      RCC1_2 20 VlcWGsNsdGQ 30
                +l+ GsN+ GQ
  EFC37785.1 44 LLSMGSNDKGQ 54
                89********9 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 6e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +k+v+aG++H + +t+++++++ G N++ Q
  EFC37785.1 102 IKHVAAGRSHLLLVTNSNKIYAMGFNNYSQ 131
                 799*********************999877 PP

  == domain 3  score: 21.6 bits;  conditional E-value: 1.5e-08
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 v+aG++Hs++L + G++++ G+  +GQ
  EFC37785.1 159 VAAGWFHSIILCDGGKIFSSGHSFFGQ 185
                 9*************************9 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.18
      RCC1_2  14 LtedGeVlcWG 24 
                 L++ ++++++G
  EFC37785.1 224 LVDGWKIYACG 234
                 788999****9 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 0.6
      RCC1_2  12 caLtedGeVl 21 
                 ++Lt  G+V+
  EFC37785.1 270 VVLTHKGNVY 279
                 689*****98 PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.0046
      RCC1_2   2 ksvsaGdyHscaLtedGeVlc 22 
                 ++++aG++++  +++  +V++
  EFC37785.1 344 IQICAGYCFYYLVVNKKRVYS 364
                 89*************999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       446  (0.0248759); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 2657.99
//
Query:       EFC37786.1  [L=385]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       759  (0.0423336); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 2214.56
//
Query:       EFC37787.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.3e-14   52.3   0.0    1.3e-13   51.1   0.0    1.6  1  NmrA             NmrA-like family
    3.8e-07   29.8   0.1    5.9e-05   22.6   0.0    2.6  3  Epimerase        NAD dependent epimerase/dehydratase family
    6.5e-07   29.4   0.0      1e-06   28.7   0.0    1.3  1  NAD_binding_10   NAD(P)H-binding
    6.8e-05   22.4   0.0    0.00017   21.1   0.0    1.6  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    0.00067   19.9   0.0     0.0017   18.6   0.0    1.6  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
    0.00097   18.6   0.0      0.013   15.0   0.0    2.1  2  adh_short        short chain dehydrogenase
     0.0085   15.3   0.0      0.014   14.6   0.0    1.4  1  NAD_binding_4    Male sterility protein
  ------ inclusion threshold ------
       0.04   12.9   0.1      0.084   11.9   0.1    1.5  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
      0.062   13.7   0.0       0.98    9.9   0.0    2.5  3  Semialdhyde_dh   Semialdehyde dehydrogenase, NAD binding doma
      0.074   13.3   0.0       0.15   12.3   0.0    1.6  1  TrkA_N           TrkA-N domain


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.1   0.0   7.1e-17   1.3e-13       1     232 [.       5     254 ..       5     255 .. 0.83

  Alignments for each domain:
  == domain 1  score: 51.1 bits;  conditional E-value: 7.1e-17
                 EEESSTTSHHHHHHHHHHHH....HT-EEEEEES-S..-SHHHHHHHHSTTEEEES-TT-HHHH...HHHHTT-SEEEE---GGS-HHHHHHHHHHHHH CS
        NmrA   1 IlviGaTGrqGksvvrallk....aghkvralvRdt..kselakslkeaGvelvkgdlddkesl...vealkgvdvvfsvtgfyskeiedgkklvdAak 90 
                 Il +GaTG +Gk + ++l +    ++ +vr++vR++   +e++k++++   e+v+gdl+d +sl   +e++++ +  f+ t    ++ ++ ++l++ a 
  EFC37787.1   5 ILLTGATGTIGKLLLEFLNEksttEELTVRIIVRNVekARENVKNFEKLKFEFVEGDLNDLDSLkdpQEVFNQIERLFILTIDSPDKSDIETRLAELAL 103
                 899***********999988777799**********767899********************9944458*************899************** PP

                 HHS..-SEEE.EEE---GG.GT.SSS---TTTHHHHHHH...HHHHHC...TS-EEEEEE-EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE CS
        NmrA  91 eaG..vkhfi.ySslgddndrsnaeepavphfdsKaeie...eyvral...gipytfvyagffmenflsllaqlkvgdtappedkvtllgpgnpkavll 180
                 e     ++++ +S lg+ +d    +    +  ++K  i+   ++ +++    +    +++++fm+n+l +      ++++  +  + +  ++np   + 
  EFC37787.1 104 EHSpsLEQIVkFSALGASEDCETNSVFRWQGEAEKSLIKllkNHNKKEknhLVSLVLIRPNLFMQNLLWN------DELESIKGGFLIRPDSNPTSLFH 196
                 998888888879*****999887777788888999999632244444477555667899********983......3445555579********99998 PP

                 ...-HHHHHHHHHHHHHHH..HHHHTTEEEEE-SE.EE-HHHHHHHHHHHHTS-EEEE CS
        NmrA 181 ...daeeDiGafvikilkd..prklkgkriklagn.tlsgneivelfekkigktvkYt 232
                    ++ +Di++ +  +l +   +k  ++ ++++g  +l+++ei+++++   gk+++Y+
  EFC37787.1 197 ishVDARDIAELISIVLLEkdHKKHGNQTYNITGPmVLTYEEIATMLSNHSGKEITYQ 254
                 9999*******997776543266666666666665169*******************8 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   3.3e-08   5.9e-05       1      58 [.       5      70 ..       5     101 .. 0.80
   2 ?    4.4   0.0     0.013        23     212     240 ..     199     228 ..     195     229 .. 0.91
   3 ?   -2.1   0.0       1.2   2.2e+03     165     196 ..     239     271 ..     237     309 .. 0.68

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 3.3e-08
                EEEETTTSHHHHHHHHHHHHCT......SEEEEEES-STTTTCHHCHHC..EEEE--TT-HHHHHH CS
   Epimerase  1 ilVtGatGfiGsalvkallekg......yevigldrlssasntarledl..elveldltdrsaler 58
                il+tGatG iG+ l++ l+ek       +++i+++ ++ ++n ++ e+l  e+ve+dl d ++l++
  EFC37787.1  5 ILLTGATGTIGKLLLEFLNEKStteeltVRIIVRNVEKARENVKNFEKLkfEFVEGDLNDLDSLKD 70
                89*******************9987755556666666666666666666***********998875 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.013
                 EEEHHHHHHHHHHHHHHHTT-STTE.EEEE CS
   Epimerase 212 flyveDvaeaillvlehvdagdkge.iyni 240
                 +++++D+ae+i  vl + d +++g+ +yni
  EFC37787.1 199 HVDARDIAELISIVLLEKDHKKHGNqTYNI 228
                 6899*************9999998889*98 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.2
                 EEEEESEEESTT.S-TTSTTSHHHHHHHHHHTT CS
   Epimerase 165 iilrlfnlyGpr.ngegevsrvipalirkileg 196
                 i+++l+n+ G+  +++  +++ ++ +++++++ 
  EFC37787.1 239 IATMLSNHSGKEiTYQAVPESYYADILKQAQLP 271
                 577889999988777766777777777776663 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.0   5.8e-10     1e-06       1     119 [.       9     139 ..       9     173 .. 0.71

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 5.8e-10
                     TTTSHHHHHHHHHHHHC-...T-EEEEEETTHHHCHHHH...CTTTCEEEE--TT-CCHHH...HHHTT-SEEEES---TCCHHHHHHHHHHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellarg...ghevtalvRnpeklaele...aeeglevvegdvtdvedla...ealkgadaVvsalggggkdeegaknivdaak 86 
                     GAtG +G+ll++ l +++   +++v+++vRn ek+ e     ++ + e vegd++d ++l+   e++++++  ++ +  + +++++  ++++ a 
      EFC37787.1   9 GATGTIGKLLLEFLNEKStteELTVRIIVRNVEKARENVknfEKLKFEFVEGDLNDLDSLKdpqEVFNQIERLFILTIDSPDKSDIETRLAELAL 103
                     9*************999999999********99997432122467889*******9987752226788888888777777777777777777665 PP

                     HCT..--EEEEEEETTTTS.GCGCHHHHHHHHCCHH CS
  NAD_binding_10  87 eag..vkRfvlvsaigvgd.evpgefgewnkellka 119
                     e+    +++v  sa+g+ +    +++ +w+ e+ k+
      EFC37787.1 104 EHSpsLEQIVKFSALGASEdCETNSVFRWQGEAEKS 139
                     554338899999999986524556666776543333 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   9.3e-08   0.00017       1      68 [.       6      69 ..       6      80 .. 0.70

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 9.3e-08
                   EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHH CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDsssle 68
                   L TG +G iG  l+e+L ek  +   +vr      ++++e+ +++ k+  + ++++++gDl+D +sl+
     EFC37787.1  6 LLTGATGTIGKLLLEFLNEKSTTEELTVR----IIVRNVEKARENVKNFEKLKFEFVEGDLNDLDSLK 69
                   78*****************9665444333....22333333333333333458**********99886 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.0   9.3e-07    0.0017       1      64 [.       5      69 ..       5      73 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 9.3e-07
                     EEEE--.SHHHHHHHHHHHCTCCT-G.EEEEEESSHHHHHHHHCHHTTTCEEEEE--TTTHHHHHH CS
  Sacchrp_dh_NADP  1 vliiGa.GsvGqavaellarhfdvda.eitvadrskeklealaakalgvrfeaialdaenyeavLa 64
                     +l+ Ga G +G+ ++e l +++  ++ ++ ++ r+ ek+++ +++  + +fe+++ d ++ ++ L+
       EFC37787.1  5 ILLTGAtGTIGKLLLEFLNEKSTTEElTVRIIVRNVEKARENVKNFEKLKFEFVEGDLNDLDS-LK 69
                     7889*******************999*********************************9998.65 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   7.2e-06     0.013       2      66 ..       4      70 ..       3      87 .. 0.78
   2 ?    1.3   0.0      0.11     2e+02     107     130 ..     226     249 ..     217     256 .. 0.91

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 7.2e-06
                EEEEESTTSHHHHHHHHHH....HHTT-EEEEEESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHHHHHH CS
   adh_short  2 vvlvtGassGIGraiakel....akeGakvvvvdrseekleevakelkeegakalaiqvDvtdreevea 66
                ++l tGa++ IG+ + + l     +e  +v ++ r+ ek++e +k+++++  k+ ++++D++d +++++
  EFC37787.1  4 IILLTGATGTIGKLLLEFLneksTTEELTVRIIVRNVEKARENVKNFEKL--KFEFVEGDLNDLDSLKD 70
                79**********98876661111567888999999999999999999986..8**********999876 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.11
                 HHTHHHHHHHHHHHHHHHHCTTEE CS
   adh_short 107 vNltgvflltravlpamlkqssGr 130
                  N+tg++ lt + + +ml+++sG+
  EFC37787.1 226 YNITGPMVLTYEEIATMLSNHSGK 249
                 69******************9997 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   7.9e-06     0.014       1      43 [.       7      48 ..       7      87 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 7.9e-06
                   EE-TTSHHHHHHHHHHHHHS-.T..EEEEEE-SSSHHHHHHHHHH CS
  NAD_binding_4  1 lTGaTGFLGkvLlekLLrttpev..kiyllvRaksgesaeeRlee 43
                   lTGaTG +Gk Lle L ++++    ++ + vR+ ++  a+e + +
     EFC37787.1  7 LTGATGTIGKLLLEFLNEKSTTEelTVRIIVRNVEK--ARENV-K 48
                   8*************9986655443577777776544..44444.2 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   4.7e-05     0.084       2      62 ..       7      70 ..       6      86 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.7e-05
   3Beta_HSD  2 vtGgaGFlGralvkeLvrleelke..vrvlDlrespelleelskvnvkk..viegDvtdkdklee 62
                +tG++G +G+ l + L +    +e  vr++ +r+ ++ +e++++++  k  ++egD++d d+l++
  EFC37787.1  7 LTGATGTIGKLLLEFLNEKSTTEEltVRII-VRNVEKARENVKNFEKLKfeFVEGDLNDLDSLKD 70
                79*******988877766555555115655.67777788888888887777********999975 PP

>> Semialdhyde_dh  Semialdehyde dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00054      0.98       4      55 ..       7      54 ..       4      79 .. 0.72
   2 ?    0.6   0.0      0.41   7.3e+02      12      32 ..     137     157 ..     132     158 .. 0.81
   3 ?   -3.5   0.0       7.4   1.3e+04      15      29 ..     239     253 ..     236     270 .. 0.60

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00054
                    EETTTSHHHHHHHHHHHCTSSEEEEEEEESTTTTTSBHHHHSGGGTTTECEB CS
  Semialdhyde_dh  4 ivGatGyvGqellrlLeehpevelvvllsssrsaGkklaeavkaleegkdlk 55
                    + GatG +G+ ll+ L+e+   e++++    r+  k+ +++++     ++lk
      EFC37787.1  7 LTGATGTIGKLLLEFLNEKSTTEELTVRIIVRNVEKARENVKN----FEKLK 54
                    67****************9998888877777755565555544....33333 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.41
                     HHHHHHHHHCTSSEEEEEEEE CS
  Semialdhyde_dh  12 GqellrlLeehpevelvvlls 32 
                      + l++lL++h + e  +l+s
      EFC37787.1 137 EKSLIKLLKNHNKKEKNHLVS 157
                     5789********999999876 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 7.4
                     HHHHHHCTSSEEEEE CS
  Semialdhyde_dh  15 llrlLeehpevelvv 29 
                     ++++L++h   e+++
      EFC37787.1 239 IATMLSNHSGKEITY 253
                     455566655555554 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   8.6e-05      0.15       6      57 ..      11      70 ..       5     117 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 8.6e-05
                -SHHHHHHHHHHHHTT.........EEEEEEESSHHHHHHHHHTTSEEEES-TTSHHHHHH CS
      TrkA_N  6 lGrvGrslaeeLsegg.........kdvvvidkdeerveelreeglevvvgdatdeevLee 57
                 G++G+ l+e L+e++         + v  ++k +e+v+++++ ++e+v gd  d + L++
  EFC37787.1 11 TGTIGKLLLEFLNEKStteeltvriI-VRNVEKARENVKNFEKLKFEFVEGDLNDLDSLKD 70
                599***********666999988744.667999999999999999************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       839  (0.0467957); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2068.60
//
Query:       EFC37788.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       459  (0.025601); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.41u 0.29s 00:00:00.70 Elapsed: 00:00:00.45
# Mc/sec: 840.20
//
Query:       EFC37789.1  [L=704]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-31  107.9   0.1    9.1e-31  106.5   0.1    1.8  1  ABC1      ABC1 family
     0.0067   16.3   0.3       0.86    9.6   0.0    2.5  2  UBA       UBA/TS-N domain


Domain annotation for each model (and alignments):
>> ABC1  ABC1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  106.5   0.1     1e-34   9.1e-31       2     118 ..     286     411 ..     285     412 .. 0.83

  Alignments for each domain:
  == domain 1  score: 106.5 bits;  conditional E-value: 1e-34
        ABC1   2 elgkkleeiFaefdeePiAaASiaqVhrAklksgeeVavKvqrpgvkkriksDlellkllakllkkflkelr..ldleelv.......defskslleEl 91 
                 ++gk++ee+F+efde+PiAaASiaqVhrA++k+g+ VavKvq+p v++ ++ D+++   + +l  k+   ++  +++++lv       +e+++ l++El
  EFC37789.1 286 DFGKSIEELFDEFDEKPIAAASIAQVHRARTKDGRLVAVKVQYPFVRSYFEGDMRTNDSMSTLSLKLYYMQEdaENIDTLVemnnkfnRELENGLYSEL 384
                 79****************************************************998887776555443333345555554222222257778899*** PP

        ABC1  92 dferEAknaekfrenfaklkevkvPkv 118
                 df++EA+na ++++++++ ++v+vPk+
  EFC37789.1 385 DFRHEASNARQAADHMKDRPDVYVPKM 411
                 *************************97 PP

>> UBA  UBA/TS-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.1    0.0042        38       1      14 [.     357     372 ..     357     377 .. 0.82
   2 !    9.6   0.0   9.6e-05      0.86       5      19 ..     434     448 ..     432     451 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0042
                 TCHHHHHHHHHTT..S CS
         UBA   1 edeeaiqrLveMG..F 14 
                 ed+e+i++LveM+  F
  EFC37789.1 357 EDAENIDTLVEMNnkF 372
                 699*********7555 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 9.6e-05
                 HHHHHHHTTS-HHHH CS
         UBA   5 aiqrLveMGFdreev 19 
                 +++r++eMGF +e+v
  EFC37789.1 434 NVERIKEMGFKEEDV 448
                 59***********87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (704 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       971  (0.0541581); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.30s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 4225.96
//
Query:       EFC37790.1  [L=1202]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-48  165.3   0.0    4.9e-47  160.5   0.0    2.2  1  AMP-binding      AMP-binding enzyme
    5.2e-20   71.7   0.0    9.8e-20   70.8   0.0    1.4  1  NAD_binding_4    Male sterility protein
     0.0059   16.9   0.0      0.017   15.5   0.0    1.8  1  PP-binding       Phosphopantetheine attachment site
  ------ inclusion threshold ------
      0.048   13.1   0.0       0.12   11.8   0.0    1.6  1  Epimerase        NAD dependent epimerase/dehydratase family
       0.16   11.8   2.1        2.1    8.2   0.5    3.4  3  Post_transc_reg  Post-transcriptional regulator


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  160.5   0.0   1.4e-50   4.9e-47      17     423 .]     244     816 ..     223     816 .. 0.84

  Alignments for each domain:
  == domain 1  score: 160.5 bits;  conditional E-value: 1.4e-50
                  CCSTEEEEHHHHHHHHHHHHHHHH..HTTSSTT-E..........EEEEESSSHHHHHHHHHHHHTT-EEEEEET...................TS-H CS
  AMP-binding  17 sgegqtlTYreldervnrlAagLr..slGvkkgdr..........VaillpnspewvvallailkaGavvvplnp...................tlta 83 
                  +  ++++T+++l+erv r++ gL   ++   ++ r          V+i++ n+++w+va+ a l  + + v l                     ++ +
   EFC37790.1 244 ETFHRWFTFEQLHERVMRFGLGLYqfEKEFLNQPRpfsqeegrgfVGICSSNRADWFVADWASLTQSFISVALPQtkvdcisedivnmesvdvlKSIS 341
                  44689******************9454555555555667778899*****************************999999999999999999888888 PP

                  HHHHHHHHHHTESEEEETCTCCC.HHHHHHHHSCC-EECEEEEESCCS-HCCHCCCHCCCCSCTTS................................ CS
  AMP-binding  84 eelayiledseakvliatvdsel.leklleaaakleavklvivldadellkeeelkeeeeseekae................................ 148
                  +e+  i+++s++ +l+  ++++l ++ l+ +++    ++++++++ +++l ++e+ + e s+++a+                                
   EFC37790.1 342 HEIICIINNSQIPLLV--CSRDLtVKFLKLIKH-GLIPSVKVIVQMEDFLVKKEEFD-ETSYKNAGeeeltkylknlravhqgkvkqhakkltsqdds 435
                  ****************..888885555555554.45667777777777776644443.334444423567889999999******************* PP

                  ........................................................................................-TSCCCS-BT CS
  AMP-binding 149 ........................................................................................kpeeeeelkp 158
                                                                                                          +     +++ 
   EFC37790.1 436 tssplyylmksryknsnlnmnvsieelcdfnksddefvihnyisendinldcksimlarelsieltdmtsielstckdyptfnnalrfNI--RTNNSV 531
                  *************************************************************************************97644..335889 PP

                  TSEEEEEEE--SSS.S-EEEEEEHHHHHHHHHHHHHHHCSCCTTT-EEEESS-TTSCHHHHHHHHHHHHTT-EEEE-TTCGCCHHHHHHHHHHHHT-S CS
  AMP-binding 159 ddlayiiYTSGTTG.kPKGVmlshrnlvanvaslkletrfklkeddvvlsilplahifglilelllallsGatvvllpkdaaldpklllelieklkvt 255
                  +dl +i+YTSG+T  +PKG++++ r++  nv+  ++++++ l    v+++++pl+hi+   +++ +++++G++ ++  ++  +d   ++++ + +++ 
   EFC37790.1 532 NDLTTIVYTSGSTStEPKGAVMTDRQYNENVQM-EIYHYHPL----VFITYAPLSHITDR-MNTTACMVNGGRSGFNCGE--MD--KVFDDYQSIQPV 619
                  *************845**************665.77777776....9************6.***************5544..34..367********* PP

                  EEEEEHHHHHHH..............HH.CCCHH.CHHHHCCGTT.-SEEEEESS-EBHHHHHHHHHHHTCEEEEEEEEGGGSSECEE.......... CS
  AMP-binding 256 viagvPrvleal..............le.sgalk.aakkakdlss.lrlvllggeplspellrffralfgeevlegYGlTEttgvvtv.......... 326
                  +   +Pr+++ l              l  +++++ ++k ++ l++ ++ +++gg++ sp++++f++++f+++v++gY  TE++ +  +          
   EFC37790.1 620 TESNTPRFYNILyaeyqrlkvlegdsLTpEKEEEiMQKVRNMLGGrIKSLVTGGASTSPQVVEFLKECFKCNVYNGYSSTECGYIGPIgvdgvdylse 717
                  ************777777666555553333334434555558888899999**********************************9444567777887 PP

                  .CHCTTTCTSTTS-BEE-TTEEEEEE-TTTSCBEETTSE...EEEEEEETTS-SEBTT-HHHHHHHEEETCCEEEEEEEEEEETT.SEEEEEEECCCE CS
  AMP-binding 327 .lpleedkkklgsvGkplpgvevkivDeetgepvpdgee...GellvrgpgvmkgYlkkpeataeafdsegrwlrTGDlgrlded.GyleivgRkkdl 419
                   ++ ee+k+ + ++ k l +ve+k+    +++++ ++++   Ge++v++ ++ +gY+++ e+t+ +fdse ++++T D+g++d++  +l+i++Rkk++
   EFC37790.1 718 kIQ-EENKQLPRHIMK-LKDVEIKLESVPELGYFITDVPfprGEICVKSSTIISGYYRDTEKTKLSFDSE-NYFQTADIGEIDKEkLRLRIIDRKKNI 812
                  444.444455555555.59***************99999999*************************955.5**********966479********** PP

                  EEET CS
  AMP-binding 420 iklr 423
                  +kl+
   EFC37790.1 813 FKLS 816
                  **85 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.8   0.0   2.7e-23   9.8e-20       1     107 [.    1081    1193 ..    1081    1197 .. 0.91

  Alignments for each domain:
  == domain 1  score: 70.8 bits;  conditional E-value: 2.7e-23
                     EE-TTSHHHHHHHHHHHHHS-.TEEEEEE-SSSHHHHHHHHHHHT-SS-H.HHHHHH.....HHTTTEEEEE--TTSGGGG--HHHHHHHHHH- CS
  NAD_binding_4    1 lTGaTGFLGkvLlekLLrttpevkiyllvRaksgesaeeRleeelekkel.fsallk.....elaerikvveGDlseprlGLseedlqelaeev 88  
                     +TG+TGF+G  L+ + L ++pe ++++ +R ks ++ +eRl ++++++   fs + k     +  +r++v+ GD+s++r+GL+++ +++l   +
     EFC37790.1 1081 ITGSTGFIGVGLVCEQLFSNPESNLTCIIRGKSLDNERERLISNVMNYCYhFSPEEKkslleTFNSRVSVILGDISMNRFGLDQDIYNKLETDI 1174
                     8************9999999999******************99988765415555447889999****************************** PP

                     -EEEE--SS-S.STTSSEE CS
  NAD_binding_4   89 dviihsaAtvnfdepykel 107 
                     d +ih+aA+vnf  +y +l
     EFC37790.1 1175 DTVIHCAANVNFIMNYTQL 1193
                     *************999886 PP

>> PP-binding  Phosphopantetheine attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   4.7e-06     0.017      24      58 ..     979    1016 ..     969    1019 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 4.7e-06
  PP-binding   24 lfdlG..lDSllavellaaleeefgveiplsdlfe.hp 58  
                  lf+ G  +DSl++v+l + l+++f+v++  + +++ ++
  EFC37790.1  979 LFESGgvVDSLSSVRLSNLLSQKFNVKLGADKILQeCK 1016
                  67766679**********************99987576 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   3.3e-05      0.12       1      81 [.    1079    1191 ..    1079    1198 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.3e-05
                  EEEETTTSHHHHHH.HHHHHHCTSE.EEEEES-STTTTCHHCHHC...........................EEEE--TT-HH......HHHHHHHH CS
   Epimerase    1 ilVtGatGfiGsal.vkallekgye.vigldrlssasntarledl...........................elveldltdrs......alerlfke 62  
                  il+tG tGfiG  l +++l ++    ++++ r +s +n+ ++  l                           +++ +d+  +         ++l + 
  EFC37790.1 1079 ILITGSTGFIGVGLvCEQLFSNPESnLTCIIRGKSLDNERER--LisnvmnycyhfspeekkslletfnsrvSVILGDISMNRfgldqdIYNKL-E- 1171
                  8**********8653899999996669999999777665433..246889*******************9996666666544444422044444.3. PP

                  HT-SEEEE--S.---HHHHH CS
   Epimerase   63 eqpdavihlAa.vggvaass 81  
                  +++d+vih+Aa v  ++++ 
  EFC37790.1 1172 TDIDTVIHCAAnVNFIMNYT 1191
                  39*******99999888765 PP

>> Post_transc_reg  Post-transcriptional regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.5    0.0006       2.1      15      41 ..     390     416 ..     384     429 .. 0.85
   2 ?   -0.8   0.0      0.39   1.4e+03      41      65 ..     797     821 ..     794     822 .. 0.89
   3 ?   -1.0   0.0      0.45   1.6e+03      60      74 ..    1183    1197 ..    1175    1200 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0006
  Post_transc_reg  15 KveEfkllgYdriteediwnylvekkw 41 
                      K eEf +  Y++  ee++ +yl++ + 
       EFC37790.1 390 KKEEFDETSYKNAGEEELTKYLKNLRA 416
                      89********************98765 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.39
  Post_transc_reg  41 wKkkeelrlhelvqdilslkineym 65 
                      +K+k  lr+ ++ ++i++l+ +e++
       EFC37790.1 797 DKEKLRLRIIDRKKNIFKLSQGEFV 821
                      5889999*************99986 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.45
  Post_transc_reg   60 kineymsyltveayk 74  
                       ++n +m+y ++ea +
       EFC37790.1 1183 NVNFIMNYTQLEARQ 1197
                       67889*******987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1202 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       946  (0.0527637); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.93u 0.30s 00:00:01.23 Elapsed: 00:00:00.51
# Mc/sec: 7146.15
//
Query:       EFC37791.1  [L=1020]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.3e-07   30.5  48.5     0.0017   18.7  11.4    3.5  3  EGF_2         EGF-like domain
  ------ inclusion threshold ------
       0.04   13.4   0.3       0.12   11.9   0.3    1.8  1  Uroplakin_II  Uroplakin II


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4  11.5   0.00063       5.7       5      32 .]     663     689 ..     655     689 .. 0.82
   2 !   18.7  11.4   1.9e-07    0.0017       5      32 .]     703     729 ..     694     729 .. 0.87
   3 !   16.6   9.7   8.3e-07    0.0074       4      32 .]     743     771 ..     741     771 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00063
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+Cv ++ +C C++  +G  C
  EFC37791.1 663 SSVCSGYGSCVGPN-RCNCQNTNFGFEC 689
                 789********888.****888888877 PP

  == domain 2  score: 18.7 bits;  conditional E-value: 1.9e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ Cgg G+C  q  qC+C+sgy+G tC
  EFC37791.1 703 QTVCGGVGKCSIQD-QCSCPSGYTGTTC 729
                 678*******7677.9************ PP

  == domain 3  score: 16.6 bits;  conditional E-value: 8.3e-07
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+g G+Cv++   C+C++g+ G +C
  EFC37791.1 743 NsSNVCSGKGSCVSTD-SCKCNAGRVGSYC 771
                 44899********777.7************ PP

>> Uroplakin_II  Uroplakin II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.3   1.3e-05      0.12     124     177 ..     952    1006 ..     917    1008 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.3e-05
  Uroplakin_II  124 ssnkvqmatlprkkveslglgmartggmvvitvllsva.mfllvvglivalaldv 177 
                    s + ++m      + ++l lg   tgg++ ++v l  a ++ +vvg+iva  ++v
    EFC37791.1  952 SFSVIDMNYKKTSRDDTLQLGGLTTGGIIALAVTLGGAgLICIVVGIIVAAIIGV 1006
                    44556677777777899****************99877367799*****987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1020 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1009  (0.0562775); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.78u 0.28s 00:00:01.06 Elapsed: 00:00:00.49
# Mc/sec: 6233.04
//
Query:       EFC37792.1  [L=267]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.064   13.7   1.6       0.11   13.0   1.6    1.4  1  Lipid_bd  Lipid-binding putative hydrolase


Domain annotation for each model (and alignments):
>> Lipid_bd  Lipid-binding putative hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   1.6     6e-06      0.11      14      93 ..      30     108 ..      18     116 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 6e-06
                 -SSEEEEE-TTSSS--EEEEEEETTTTEEE-SSEEESSSSE......EEEEEEEEEEEEEEE-TTS-EEEEEEEEEEETT CS
    Lipid_bd  14 dadkmwlddkgnfwevkvkvnvdvesltFsgeevenvaydsgatatvkvkiteGkvleeaattpsgtkaDsivftvsfsd 93 
                 +  k  +  +++fwe +   +  +++ + + + ++n +y+ +++ + +  i +G v++++   ++ +  D iv+t++ ++
  EFC37792.1  30 KDVKFCMPPQATFWETTKDASYIMKEFKNNDQVIKN-QYNVKTSQQRQDFIVKGNVVKSEISIQNPMNNDTIVYTLTSDN 108
                 555566666778888888777777776666677888.666656555555566************************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1067  (0.0595125); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1569.68
//
Query:       EFC37793.1  [L=762]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
        1.1    9.0   3.0        1.4    8.7   0.5    2.5  3  Methyltransf_31  Methyltransferase domain


Domain annotation for each model (and alignments):
>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.25   4.5e+03      87     119 ..      90     101 ..      67     153 .. 0.61
   2 ?   -1.9   0.0      0.15   2.7e+03      91     119 ..     310     339 ..     249     367 .. 0.65
   3 ?    8.7   0.5   7.8e-05       1.4      91     136 ..     612     654 ..     518     686 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.25
  Methyltransf_31  87 ladpdkileeiervlkpggilliedprllaelp 119
                      l                     ++++++l++ p
       EFC37793.1  90 L---------------------MNYCKTLQQEP 101
                      3.....................44444444444 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.15
  Methyltransf_31  91 dkileeiervlkpggilliedpr.llaelp 119
                       + + +i+   ++ ++++i+dp+ +l+e++
       EFC37793.1 310 SSLYPNISLTKSETTEVIISDPSmVLKEMK 339
                      445555555556666666666664222222 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 7.8e-05
  Methyltransf_31  91 dkileeiervlkpggilliedprllaelpakveeeskayevvegak 136
                       ++l+++++v+ ++g + +++++   +lp++++e + + + ++ ++
       EFC37793.1 612 YNCLRKMKQVILDNGDCTLREVS---QLPKHIKELCLEFTRWNLNI 654
                      479********************...********999664444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (762 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       989  (0.055162); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 4479.52
//
Query:       EFC37794.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.9e-38  127.2  47.2      9e-06   25.3   0.2   13.6 14  LRR_6         Leucine Rich repeat
    1.3e-19   69.9  50.4    0.00014   22.2   0.3    8.6 10  LRR_4         Leucine Rich repeats (2 copies)
    1.4e-19   69.6  36.4      5e-09   35.8   2.1    5.7  6  LRR_8         Leucine rich repeat
    4.8e-09   36.0  16.4    6.2e-05   22.6   3.6    3.6  3  LRR_9         Leucine-rich repeat
  ------ inclusion threshold ------
       0.53   11.0  38.4         12    7.0   0.0   10.6 12  LRR_1         Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1     0.059   2.1e+02       3      18 ..       8      23 ..       6      29 .. 0.85
   2 !   17.5   0.1   8.2e-07    0.0029       4      23 ..      34      53 ..      31      54 .. 0.91
   3 !   22.0   1.0   2.9e-08    0.0001       2      24 .]      57      79 ..      56      79 .. 0.93
   4 ?    2.1   0.1     0.071   2.6e+02       3      16 ..      82      95 ..      80      96 .. 0.84
   5 !   12.2   0.3   4.3e-05      0.15       3      23 ..     104     124 ..     102     125 .. 0.89
   6 !   13.0   0.0   2.3e-05     0.083       3      24 .]     128     149 ..     126     149 .. 0.94
   7 !    9.1   0.2    0.0004       1.4       4      24 .]     153     173 ..     150     173 .. 0.92
   8 !    6.8   0.0    0.0022         8       5      21 ..     179     195 ..     177     197 .. 0.80
   9 !    9.4   0.1   0.00033       1.2       4      24 .]     202     222 ..     199     222 .. 0.92
  10 !   25.3   0.2   2.5e-09     9e-06       4      24 .]     226     246 ..     223     246 .. 0.92
  11 !   18.4   0.0   4.3e-07    0.0015       3      24 .]     249     270 ..     247     270 .. 0.89
  12 !   10.8   0.1   0.00011      0.41       3      24 .]     273     294 ..     271     294 .. 0.87
  13 ?    4.0   0.0     0.018        64       4      23 ..     299     318 ..     296     318 .. 0.84
  14 ?   -1.2   0.0      0.81   2.9e+03       2       8 ..     320     326 ..     319     327 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.059
       LRR_6  3 thLteLdLsgNdIgDe 18
                + L+ L+L   dIg+e
  EFC37794.1  8 NQLKILELELSDIGNE 23
                5699**********98 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 8.2e-07
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                 Lt+L++ +NdIg+eG++ +
  EFC37794.1 34 QLTKLSVGFNDIGGEGLKLI 53
                59***************976 PP

  == domain 3  score: 22.0 bits;  conditional E-value: 2.9e-08
       LRR_6  2 nthLteLdLsgNdIgDeGaeaLa 24
                +++Lt L++ +N+Ig+eG+e L+
  EFC37794.1 57 SNSLTILNIEHNQIGNEGLELLS 79
                589*****************986 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.071
       LRR_6  3 thLteLdLsgNdIg 16
                t L +Ld+s N+I+
  EFC37794.1 82 TRLDSLDISTNKID 95
                56779*******97 PP

  == domain 5  score: 12.2 bits;  conditional E-value: 4.3e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 + Lt L++s N +g+eG++ +
  EFC37794.1 104 NQLTILNVSNNIVGNEGVKFI 124
                 679***************977 PP

  == domain 6  score: 13.0 bits;  conditional E-value: 2.3e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  hLteL ++++++  eG+++++
  EFC37794.1 128 KHLTELVMQSCNVKEEGMKSIC 149
                 6*******************98 PP

  == domain 7  score: 9.1 bits;  conditional E-value: 0.0004
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt  ++s N I +eG++ ++
  EFC37794.1 153 NLTNFNISNNFIRNEGMILIC 173
                 89****************998 PP

  == domain 8  score: 6.8 bits;  conditional E-value: 0.0022
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 L+ L  s+N+I++eG++
  EFC37794.1 179 LKCLRASSNKISNEGVQ 195
                 5666669********97 PP

  == domain 9  score: 9.4 bits;  conditional E-value: 0.00033
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt L++  N+I++ G+++++
  EFC37794.1 202 RLTDLNICRNEISNNGMKSIS 222
                 59****************996 PP

  == domain 10  score: 25.3 bits;  conditional E-value: 2.5e-09
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt Ld+sgN+I+DeGa++++
  EFC37794.1 226 KLTCLDVSGNNISDEGATSIS 246
                 8*****************996 PP

  == domain 11  score: 18.4 bits;  conditional E-value: 4.3e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + L +L +++N+IgDeG+e+++
  EFC37794.1 249 SQLSSLYINDNQIGDEGMESIS 270
                 56889**************996 PP

  == domain 12  score: 10.8 bits;  conditional E-value: 0.00011
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L +L +++N+Ig+ Ga+a++
  EFC37794.1 273 NNLSKLWINDNQIGNIGAKAIS 294
                 577788899***********96 PP

  == domain 13  score: 4.0 bits;  conditional E-value: 0.018
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L ++ N Ig eG++ L
  EFC37794.1 299 QLTFLFIANNRIGEEGIKLL 318
                 68888899********9976 PP

  == domain 14  score: -1.2 bits;  conditional E-value: 0.81
       LRR_6   2 nthLteL 8  
                 n++Lt+L
  EFC37794.1 320 NMKLTYL 326
                 99****9 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.2    0.0021       7.5       6      39 ..      15      45 ..       8      56 .. 0.68
   2 !   17.7   5.1     1e-06    0.0036       2      41 ..      59      99 ..      58     104 .. 0.83
   3 !    7.3   2.1    0.0019       6.7      11      33 ..      92     114 ..      92     127 .. 0.82
   4 !   11.4   0.7   9.4e-05      0.34       2      33 ..     105     138 ..     104     143 .. 0.77
   5 !   14.0   1.7   1.5e-05     0.052       1      37 [.     128     165 ..     128     167 .. 0.84
   6 !   12.6   1.4   3.9e-05      0.14       3      42 ..     179     224 ..     177     225 .. 0.72
   7 !   16.5   0.4   2.3e-06    0.0083       8      36 ..     213     237 ..     212     249 .. 0.86
   8 !   22.2   0.3   3.8e-08   0.00014       1      38 [.     225     263 ..     225     267 .. 0.89
   9 !   19.1   1.2   3.6e-07    0.0013       2      39 ..     250     288 ..     249     294 .. 0.84
  10 !   14.5   2.8     1e-05     0.036       2      37 ..     274     311 ..     273     332 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0021
                EE--SS---E-S-HH...H-TT--EEE-.-S-----G CS
       LRR_4  6 LdLsnNqltdiplle...klpnLkeLdLsgNnlitdl 39
                L Ls+  +   +l++   ++++L++L++ +N    d+
  EFC37794.1 15 LELSD--IGNEQLIQisqSMKQLTKLSVGFN----DI 45
                44444..554444334536*********778....77 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 1e-06
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGG CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdlde 41
                +L++L++ +Nq+   +l  l++l+ L +Ld+s N +i+++++
  EFC37794.1 59 SLTILNIEHNQIGNEGLelLSGLTRLDSLDISTN-KIDKFNS 99
                79***********766676668*********777.8877755 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0019
                 S---E-S-HHH-TT--EEE-.-S CS
       LRR_4  11 NqltdiplleklpnLkeLdLsgN 33 
                 N++ +++++ +l +L+ L++s+N
  EFC37794.1  92 NKIDKFNSICNLNQLTILNVSNN 114
                 78888888666*********776 PP

  == domain 4  score: 11.4 bits;  conditional E-value: 9.4e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 +L++L+ snN +   +   ++kl++L+eL + ++
  EFC37794.1 105 QLTILNVSNNIVGNEGVkfISKLKHLTELVMQSC 138
                 69******97777555585447*******99665 PP

  == domain 5  score: 14.0 bits;  conditional E-value: 1.5e-05
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 ++L++L  +++++++ +    +e l+nL+ +++ +Nn+i+
  EFC37794.1 128 KHLTELVMQSCNVKEEGMksiCE-LKNLTNFNI-SNNFIR 165
                 58************988886555.*********.666886 PP

  == domain 6  score: 12.6 bits;  conditional E-value: 3.9e-05
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S....-----GGGG CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgN....nlitdldeL 42 
                 L+ L  s+N+++  +   + kl  L+ L++ +N    n  +++++L
  EFC37794.1 179 LKCLRASSNKISNEGVqdITKLERLTDLNICRNeisnNGMKSISGL 224
                 999*********766676669********85552222566666665 PP

  == domain 7  score: 16.5 bits;  conditional E-value: 2.3e-06
                 --SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   8 LsnNqltdiplleklpnLkeLdLsgNnli 36 
                 +snN +++i++   l++L+ Ld+sgNn i
  EFC37794.1 213 ISNNGMKSISG---LKKLTCLDVSGNN-I 237
                 69*********...************4.3 PP

  == domain 8  score: 22.2 bits;  conditional E-value: 3.8e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L+ Ld s+N+++d +   +++l +L +L++++N +i+d
  EFC37794.1 225 KKLTCLDVSGNNISDEGAtsISQLSQLSSLYINDN-QIGD 263
                 69*************99987667*********777.9976 PP

  == domain 9  score: 19.1 bits;  conditional E-value: 3.6e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +L +L++++Nq+ d +   ++ + nL +L++++N +i+++
  EFC37794.1 250 QLSSLYINDNQIGDEGMesISEMNNLSKLWINDN-QIGNI 288
                 5789**********99975335*********666.99998 PP

  == domain 10  score: 14.5 bits;  conditional E-value: 1e-05
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 nL +L++++Nq+  i+      ++ +L+ L +  Nn+i+
  EFC37794.1 274 NLSKLWINDNQIGNIGAkaiSVNMHQLTFLFI-ANNRIG 311
                 899**************874448*********.777885 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.2     0.091   3.3e+02      40      61 .]      28      45 ..       5      45 .. 0.58
   2 !   25.2   9.4   2.9e-09     1e-05       2      59 ..      59     114 ..      58     116 .. 0.97
   3 !    8.8   0.5   0.00036       1.3       2      38 ..     129     165 ..     122     168 .. 0.83
   4 !   24.9   0.9   3.5e-09   1.2e-05       9      61 .]     185     237 ..     177     237 .. 0.88
   5 !   35.8   2.1   1.4e-12     5e-09       2      61 .]     202     261 ..     201     261 .. 0.98
   6 !   22.3   2.0   2.3e-08   8.3e-05       1      61 []     249     310 ..     249     310 .. 0.96

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.091
                GGGGGGTT--S-.EEE--SS-- CS
       LRR_8 40 lspgafsgLpsLrsLdLsgNrL 61
                +s    +++++L++L +  N++
  EFC37794.1 28 IS----QSMKQLTKLSVGFNDI 45
                33....5666677777766665 PP

  == domain 2  score: 25.2 bits;  conditional E-value: 2.9e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+L++ +N++ + + e  +gl++L +Ld+s N+++ ++  ++ +L++L+ L++s+N
  EFC37794.1  59 SLTILNIEHNQIGNEGLELLSGLTRLDSLDISTNKIDKFN--SICNLNQLTILNVSNN 114
                 79*************************************7..***************9 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00036
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 +Lt+L+ ++ + ++ + ++   l+nL+ +++snN ++
  EFC37794.1 129 HLTELVMQSCNVKEEGMKSICELKNLTNFNISNNFIR 165
                 7888888888888888888888999999999998775 PP

  == domain 4  score: 24.9 bits;  conditional E-value: 3.5e-09
                 TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   9 snNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 s+N++++ + +  ++l++L+ L++ +N+++    +++sgL++L+ Ld+sgN++
  EFC37794.1 185 SSNKISNEGVQDITKLERLTDLNICRNEISNNGMKSISGLKKLTCLDVSGNNI 237
                 677777777788899************************************97 PP

  == domain 5  score: 35.8 bits;  conditional E-value: 1.4e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L++++N +++ + ++ +gl++L+ Ld s N+++   + ++s+L++L sL++++N++
  EFC37794.1 202 RLTDLNICRNEISNNGMKSISGLKKLTCLDVSGNNISDEGATSISQLSQLSSLYINDNQI 261
                 79********************************************************98 PP

  == domain 6  score: 22.3 bits;  conditional E-value: 2.3e-08
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGT.T--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafs.gLpsLrsLdLsgNrL 61 
                 ++L+sL++++N++ + + e+ + ++nL  L +++N++  + ++a+s ++++L++L + +Nr+
  EFC37794.1 249 SQLSSLYINDNQIGDEGMESISEMNNLSKLWINDNQIGNIGAKAISvNMHQLTFLFIANNRI 310
                 589*****************************************8549************97 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   3.6   1.7e-08   6.2e-05      40     127 ..      80     166 ..      66     170 .. 0.91
   2 !    6.9   0.2    0.0011         4      60     126 ..     176     238 ..     167     243 .. 0.77
   3 !   14.4   0.3   5.7e-06     0.021      41     102 ..     248     312 ..     236     330 .. 0.64

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 1.7e-08
       LRR_9  40 tldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                  l ++d++d+s n+i k++++  l++l +l ++nn + + + ++   l +l+elv+++ +++e + ++ + +lk+l+++ + +n + n
  EFC37794.1  80 GLTRLDSLDISTNKIDKFNSICNLNQLTILNVSNNIVGNEGVKFISKLKHLTELVMQSCNVKEEG-MKSICELKNLTNFNISNNFIRN 166
                 56789********************************99999999****************9976.599*********9998887765 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0011
       LRR_9  60 fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 fPl   lk+l  ++n+i + + +    l +l+ l +  ne+ + + ++ +  lkkl++l +  n ++
  EFC37794.1 176 FPL---LKCLRASSNKISNEGVQDITKLERLTDLNICRNEISNNG-MKSISGLKKLTCLDVSGNNIS 238
                 554...678888999998655544556889999999999998855.699999999999998888876 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 5.7e-06
       LRR_9  41 ldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriae.gleevlPnleelvltnnelqe 102
                 l q+ ++ ++dn+i +  ++++  ++ l  l +n+n+i +i+   ++  + +l+ l ++nn++ e
  EFC37794.1 248 LSQLSSLYINDNQIGDegMESISEMNNLSKLWINDNQIGNIGAkAISVNMHQLTFLFIANNRIGE 312
                 55666666777777432367777777777777777777777541456666777777777777665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.8   6.5e+03       2       8 ..      10      16 ..       9      30 .. 0.49
   2 ?    0.4   0.0      0.44   1.6e+03       2      18 ..      35      51 ..      34      56 .. 0.75
   3 ?    6.0   0.3    0.0068        24       1      18 [.      59      76 ..      59      82 .. 0.74
   4 ?    0.4   0.3      0.47   1.7e+03       2      21 ..      84     101 ..      83     103 .. 0.66
   5 ?    4.6   0.2     0.019        68       2      19 ..     106     123 ..     105     130 .. 0.73
   6 ?   -1.5   0.0       1.9   6.7e+03       1      11 [.     129     139 ..     126     151 .. 0.62
   7 ?    2.2   2.2      0.11   4.1e+02       1      13 [.     153     169 ..     153     197 .. 0.78
   8 ?    2.2   0.2      0.12   4.3e+02       1      20 [.     202     221 ..     199     224 .. 0.69
   9 ?    7.0   0.0    0.0032        12       1      22 [.     226     247 ..     226     248 .. 0.87
  10 ?    3.2   0.0     0.053   1.9e+02       2      20 ..     251     269 ..     250     272 .. 0.80
  11 ?    2.5   0.0     0.093   3.3e+02       1      21 [.     274     294 ..     274     296 .. 0.85
  12 ?   -0.6   0.0      0.98   3.5e+03       2      18 ..     300     316 ..     299     321 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.8
       LRR_1  2 LrhLdLs 8 
                L+ L L+
  EFC37794.1 10 LKILELE 16
                7777552 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.44
       LRR_1  2 LrhLdLsnnpllglppn 18
                L++L ++ n ++g +  
  EFC37794.1 35 LTKLSVGFNDIGGEGLK 51
                999******99776655 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0068
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L+ L++++n++++ + +
  EFC37794.1 59 SLTILNIEHNQIGNEGLE 76
                699********9655444 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.47
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L +Ld+s n ++    ns++
  EFC37794.1  84 LDSLDISTNKID--KFNSIC 101
                 7789**999983..335555 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.019
       LRR_1   2 LrhLdLsnnpllglppns 19 
                 L+ L++snn+ ++ +   
  EFC37794.1 106 LTILNVSNNIVGNEGVKF 123
                 99*******975555554 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 1.9
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++L + +++
  EFC37794.1 129 HLTELVMQSCN 139
                 34555566665 PP

  == domain 7  score: 2.2 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnpl....l 13 
                 nL+  ++snn++     
  EFC37794.1 153 NLTNFNISNNFIrnegM 169
                 89999******855551 PP

  == domain 8  score: 2.2 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+ L++++n +++ +  s+
  EFC37794.1 202 RLTDLNICRNEISNNGMKSI 221
                 47778999999865555555 PP

  == domain 9  score: 7.0 bits;  conditional E-value: 0.0032
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L+ Ld+s+n++++ ++ s++ 
  EFC37794.1 226 KLTCLDVSGNNISDEGATSISQ 247
                 7999********9999888875 PP

  == domain 10  score: 3.2 bits;  conditional E-value: 0.053
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L +L++++n++++ + +s+
  EFC37794.1 251 LSSLYINDNQIGDEGMESI 269
                 889*******988777666 PP

  == domain 11  score: 2.5 bits;  conditional E-value: 0.093
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL +L +++n+++++++ +++
  EFC37794.1 274 NLSKLWINDNQIGNIGAKAIS 294
                 8999********998887775 PP

  == domain 12  score: -0.6 bits;  conditional E-value: 0.98
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L+ L + nn+++  ++ 
  EFC37794.1 300 LTFLFIANNRIGEEGIK 316
                 889999***99655555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       672  (0.0374812); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2054.33
//
Query:       EFC37795.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 1610.65
//
Query:       EFC37796.1  [L=1286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.5e-34  119.6   6.4    1.5e-34  119.6   6.4    2.8  3  REJ          REJ domain
    3.4e-08   33.7 137.8    0.00028   21.2  13.3   11.1 11  EGF_2        EGF-like domain
    4.6e-07   29.9 110.5    0.00096   19.2  11.9    7.2  6  Laminin_EGF  Laminin EGF domain
     0.0025   17.5   0.2     0.0025   17.5   0.2    2.8  4  Big_3_3      Bacterial Ig-like domain (group 3)
     0.0046   16.9   2.4     0.0046   16.9   2.4    2.8  2  TMEM154      TMEM154 protein family


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.4   0.2    0.0076        27      99     211 ..     428     524 ..     415     611 .. 0.66
   2 !  119.6   6.4   4.3e-38   1.5e-34     165     435 ..     684     942 ..     621     957 .. 0.78
   3 ?   -3.7   1.0         1   3.8e+03     207     288 ..    1105    1195 ..    1097    1226 .. 0.42

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.0076
         REJ  99 gnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrs..rksasteqti 195
                 g++ Ld+s+S   d+       l ++++ ++         +n +l++ ++ +s      s s+++f+ ++++ +  y +++ v+     r  + ++   
  EFC37796.1 428 GTMFLDASSSTSLDRR-----RLLFTFSAVTAP-------NNQALSNLNNLIS----GNSASTVKFSVNNFTGG-SYSVQVAVQSTFsgR-VSYATFAF 508
                 7899999999999887.....478999986666.......5555555555555....56677888888888888.577777776655435.66677777 PP

         REJ 196 lvvdgepplvsiecis 211
                  v+d  pp +si+   
  EFC37796.1 509 MVTDASPPNLSIKNGV 524
                 7777778888877543 PP

  == domain 2  score: 119.6 bits;  conditional E-value: 4.3e-38
         REJ 165 paselvanltynftltvskrsrksasteqtilvvdgepp..lvsiecisncngkvnpndr.lvllasclncakdlkdvtfeWslsqtseeysllpdkat 260
                 ++++  ++  y ft + +k+sr s+s ++ +++ +++    +++i ++sn++ +  + ++ l+l+a  +++++ + +  ++W    t      +  + +
  EFC37796.1 684 FNQKYGPG-VYLFTAVYTKGSRFSSSKVKITVTSQSKSSflRIYINTPSNIDLTSVDPSTyLILQA--QSIDSLSVQRIYSW----T------TDFDSS 769
                 45556677.5************88888777777777765115566666666654444444255554..555554455669**....3......334568 PP

         REJ 261 sslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaftvrC.qgwtDkdqPLgYevsysqrrasg 358
                 s+ +   ++ +L i ++ L +g+sy++++  ++ +g+k g   isf vn+pPt G+++++P++gval+++f+v+C +gw+D+++PL++++ y+ + +  
  EFC37796.1 770 STSSLDLNKKYLSIPKSLLVPGASYTVSV--KVVDGAKVGEGVISFVVNSPPTLGSLEINPSTGVALTDEFKVSCgNGWSDVQLPLTFKFLYRLQGDVF 866
                 8888899999*******************..9999999999*************************************************888887776 PP

         REJ 359 pyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarvsvsltitVkppavnns......tieellenrtrnenelsk 435
                  +++l e+s+  s s+++P+G        +++  VyD +ga+++++  i+V+ p   +s       i++   ++++++++ls+
  EFC37796.1 867 -WKVLKERSETRSFSTVMPSGHI------EIKSIVYDALGAATETTQIIQVTNPVDITSavqslnAISTSSVTSSSTSSALSV 942
                 .**********************......9**************************999544333344444444444444444 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 1
         REJ  207 iecisncngkvnpndrlvllasclncakd..lkdvtfeWslsqtseeysllpdkatsslttgterpr.........Lvike..nkLqsgesyalt 288 
                  ++  sn n++++  +++ l+   +++++   l +v    +++q++e+ +    k+ s  + +t++           L+i+   +++q+ ++y+ +
  EFC37796.1 1105 VSSLSNLNDTISSESSFSLSQPFSTLSQFsnLDTVKLVMKVQQQNESVT----KLFSFKVVSTNTEIpissdsiaeLTIENndGVVQNAATYECK 1195
                  5555555555555555555544222321111222222222222222222....222222222221112222222224444333444444444444 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   9.6      0.31   1.1e+03       5      32 .]      15      47 ..      11      47 .. 0.74
   2 ?    3.1   3.5     0.035   1.3e+02      19      29 ..      53      71 ..      48      74 .. 0.68
   3 !   13.7   5.3   1.7e-05      0.06       5      32 .]      94     121 ..      89     121 .. 0.83
   4 ?    2.8   1.4     0.045   1.6e+02      23      32 .]     124     133 ..     123     133 .. 0.95
   5 !   17.7   8.3   9.7e-07    0.0035       5      32 .]     146     172 ..     138     172 .. 0.88
   6 !   12.5   6.1   4.1e-05      0.15       5      28 ..     185     207 ..     181     212 .. 0.84
   7 ?   -0.2   0.7      0.39   1.4e+03      22      32 .]     214     224 ..     209     224 .. 0.90
   8 !   21.2  13.3   7.7e-08   0.00028       1      32 []     229     258 ..     229     258 .. 0.95
   9 ?    0.6   0.4      0.22   7.9e+02      22      32 .]     260     270 ..     260     270 .. 0.94
  10 !   14.2  13.9   1.2e-05     0.042       1      32 []     274     303 ..     274     303 .. 0.94
  11 !    4.9   1.9    0.0093        33      23      32 .]     306     315 ..     305     315 .. 0.96

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.31
       EGF_2  5 deiCgghGtCvnqcG........qCdCdsgyqGktC 32
                +++C+ +G+C+             C+C+  + G  C
  EFC37796.1 15 CSQCQ-NGICR--LSqssidgstHCECSGLFEGEFC 47
                66787.6***6..33224777755*********999 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.035
       EGF_2 19 G......qCdCdsgyq..G 29
                G      +C+C++gyq  G
  EFC37796.1 53 GfvklsdKCVCPNGYQqiG 71
                55555558*******9444 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 1.7e-05
       EGF_2   5 deiCgghGtCvnqcGq..CdCdsgyqGktC 32 
                 d +C+ hG+C+   +   C+C+ ++ G+ C
  EFC37796.1  94 DRACSYHGICN--LNThlCECSENFDGDRC 121
                 678*******8..43334************ PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.045
       EGF_2  23 CdsgyqGktC 32 
                 C++gy+G +C
  EFC37796.1 124 CKTGYTGSKC 133
                 ********** PP

  == domain 5  score: 17.7 bits;  conditional E-value: 9.7e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+  G Cv++   C+C+++y+G++C
  EFC37796.1 146 STVCNSKGDCVAPD-SCQCNANYYGPNC 172
                 678********999.7************ PP

  == domain 6  score: 12.5 bits;  conditional E-value: 4.1e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyq 28 
                  + C+ hGtC n+  +C C+s+y 
  EFC37796.1 185 ALVCSSHGTCSNAD-VCTCSSNYD 207
                 678*******9888.9****9995 PP

  == domain 7  score: -0.2 bits;  conditional E-value: 0.39
       EGF_2  22 dCdsgyqGktC 32 
                 +C ++y G +C
  EFC37796.1 214 KCLPSYNGTDC 224
                 699******** PP

  == domain 8  score: 21.2 bits;  conditional E-value: 7.7e-08
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 Cs+ +++C+ghG+C++q  qC C+ +++G +C
  EFC37796.1 229 CSP-ETTCRGHGQCNDQL-QCICNGKFTGTYC 258
                 887.799***********.************* PP

  == domain 9  score: 0.6 bits;  conditional E-value: 0.22
       EGF_2  22 dCdsgyqGktC 32 
                 +C +g+ G +C
  EFC37796.1 260 KCLDGWVGSNC 270
                 6********** PP

  == domain 10  score: 14.2 bits;  conditional E-value: 1.2e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 Csa +++C+g G+C  ++G C C++  +G++C
  EFC37796.1 274 CSA-QTTCSGKGSCS-STGSCICSATSYGDHC 303
                 999.79********7.689************* PP

  == domain 11  score: 4.9 bits;  conditional E-value: 0.0093
       EGF_2  23 CdsgyqGktC 32 
                 C++g++G++C
  EFC37796.1 306 CKDGWYGANC 315
                 ********** PP

>> Laminin_EGF  Laminin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2  15.0    0.0033        12      13      42 ..      18      58 ..      10      65 .. 0.76
   2 !   19.2  11.9   2.7e-07   0.00096       3      42 ..      97     132 ..      94     138 .. 0.86
   3 ?    1.2  10.5      0.12   4.3e+02      11      32 ..     147     173 ..     133     184 .. 0.76
   4 ?   -4.0  15.9       4.7   1.7e+04       3      41 ..     188     222 ..     176     235 .. 0.64
   5 !   10.2  15.3   0.00019      0.67       3      41 ..     235     268 ..     228     274 .. 0.81
   6 !   13.7  16.3   1.5e-05     0.053       3      41 ..     270     313 ..     269     318 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0033
                 EET...........TTECESBTTTEESTTS-EE-TTEEEGT CS
  Laminin_EGF 13 Cds...........stgqClCkenveGrkCdrCkpgyyglp 42
                 C++            + +C+C   +eG+ C++Ck+g+++l+
   EFC37796.1 18 CQNgicrlsqssidGSTHCECSGLFEGEFCQECKDGFVKLS 58
                 33344444888877889*********************983 PP

  == domain 2  score: 19.2 bits;  conditional E-value: 2.7e-07
                  CCTTTBCCSSEETTTECESBTTTEESTTS-EE-TTEEEGT CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCdrCkpgyyglp 42 
                  C+ hg     C+ +t  C+C en++G++C  Ck gy g +
   EFC37796.1  97 CSYHG----ICNLNTHLCECSENFDGDRCSTCKTGYTGSK 132
                  55555....9**************************9975 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.12
                  SSEET.....TTECESBTTTEESTTS- CS
  Laminin_EGF  11 ssCds.....stgqClCkenveGrkCd 32 
                  + C+s         C+C+ n+ G++C 
   EFC37796.1 147 TVCNSkgdcvAPDSCQCNANYYGPNCA 173
                  56666666666899************6 PP

  == domain 4  score: -4.0 bits;  conditional E-value: 4.7
                  CCTTTBCCSSEETTTECESBTTTEESTT.S-EE-TTEEEG CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrk.CdrCkpgyygl 41 
                  C++hg    +C +   +C C  n++ ++ C +C p y g 
   EFC37796.1 188 CSSHG----TCSN-ADVCTCSSNYDSSTfCSKCLPSYNGT 222
                  44444....5554.66777777776654477777777765 PP

  == domain 5  score: 10.2 bits;  conditional E-value: 0.00019
                  CCTTTBCCSSEETTTECESBTTTEESTTS-EE-TTEEEG CS
  Laminin_EGF   3 CnphgsssssCdsstgqClCkenveGrkCdrCkpgyygl 41 
                  C +hg    +C+  + qC C+ +++G+ C++C +g +g 
   EFC37796.1 235 CRGHG----QCND-QLQCICNGKFTGTYCEKCLDGWVGS 268
                  55555....9*99.*********************9987 PP

  == domain 6  score: 13.7 bits;  conditional E-value: 1.5e-05
                  CCTTTBCCSSEET.....TTECESBTTTEESTTS-EE-TTEEEG CS
  Laminin_EGF   3 CnphgsssssCds.....stgqClCkenveGrkCdrCkpgyygl 41 
                  C+ + s +++C       stg C C     G++C++Ck+g yg 
   EFC37796.1 270 CDITCSAQTTCSGkgscsSTGSCICSATSYGDHCENCKDGWYGA 313
                  6666666666666666667***********************97 PP

>> Big_3_3  Bacterial Ig-like domain (group 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.2     7e-07    0.0025       4      55 ..     474     525 ..     471     540 .. 0.88
   2 ?   -3.8   0.0       2.5   8.8e+03     120     133 ..     790     803 ..     787     805 .. 0.83
   3 ?   -3.5   0.3         2   7.1e+03      51      81 ..     909     940 ..     883     947 .. 0.49
   4 ?   -3.0   0.1       1.5   5.2e+03      55      79 ..    1049    1073 ..    1003    1080 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 7e-07
     Big_3_3   4 tvtfdlkelpeGkynlvlaakdtfnnqvtksllstilvdntpPtvsisegkk 55 
                 tv+f++++   G+y++++a + tf ++v   +   +++d +pP +si +g +
  EFC37796.1 474 TVKFSVNNFTGGSYSVQVAVQSTFSGRVSYATFAFMVTDASPPNLSIKNGVS 525
                 899******************************9*************55543 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 2.5
     Big_3_3 120 egesYtltvkaeDe 133
                 +g sYt++vk+ D 
  EFC37796.1 790 PGASYTVSVKVVDG 803
                 6889******9995 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 2
     Big_3_3  51 segkkisdgavvkglenlri.tladaldkskl 81 
                 +  +++   ++v++l+ +   ++++++++s l
  EFC37796.1 909 QVTNPVDITSAVQSLNAISTsSVTSSSTSSAL 940
                 22444444555555555543134444444444 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 1.5
     Big_3_3   55 kisdgavvkglenlritladaldks 79  
                  k+ ++ +++ + +++it+ d+++++
  EFC37796.1 1049 KNGEKRAIYVFSKVDITMLDQIKET 1073
                  5556678889999999999998874 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   4.9       3.6   1.3e+04      13      46 ..     929     959 ..     909     993 .. 0.60
   2 !   16.9   2.4   1.3e-06    0.0046      54      89 ..    1246    1282 ..    1201    1285 .. 0.76

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3.6
     TMEM154  13 etatleeesadatsaasteseslk..qeeakeslss 46 
                 ++ t +++s+ +++      +slk  ++e+k++ls+
  EFC37796.1 929 SSVTSSSTSSALSV-----IQSLKpqTQEEKQKLSE 959
                 22222222222222.....33333433344444444 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 1.3e-06
     TMEM154   54 dqlel..vlmiiiPlvllillllvviiliqkkkrkrsK 89  
                  d+l+    l +i+P v+li+++++v++ + + krkr+K
  EFC37796.1 1246 DNLKYlaFLSLIVPIVVLIVIVFIVVVCV-IRKRKRAK 1282
                  33333337889**************9999.99999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1686  (0.0940376); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.05u 0.31s 00:00:01.36 Elapsed: 00:00:00.50
# Mc/sec: 7718.28
//
Query:       EFC37797.1  [L=918]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-20   72.7   6.4    4.6e-06   26.4   0.0    5.7  6  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom
    2.3e-17   62.7   3.7    2.1e-07   30.6   0.2    4.0  4  RRM_5     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom
  ------ inclusion threshold ------
       0.13   12.5   1.0        6.8    7.0   0.1    3.2  3  BRAP2     BRCA1-associated protein 2


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.035   2.1e+02       4      18 ..     215     229 ..     212     236 .. 0.88
   2 !   13.9   0.1     6e-06     0.036      35      65 ..     259     289 ..     249     294 .. 0.81
   3 !   24.4   0.1   3.3e-09   1.9e-05      12      62 ..     354     401 ..     349     410 .. 0.88
   4 !   26.4   0.0   7.7e-10   4.6e-06       1      57 [.     623     680 ..     623     686 .. 0.93
   5 ?   -2.6   0.0      0.86   5.2e+03       3      17 ..     781     795 ..     779     801 .. 0.84
   6 !    4.4   0.0    0.0055        33      36      68 ..     831     863 ..     819     865 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.035
                 ESETTTSSHHHHHHH CS
       RRM_1   4 gnLppdvteeeLkel 18 
                 +nLpp++ ++eL e+
  EFC37797.1 215 SNLPPNCQKSELLEF 229
                 7***********875 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 6e-06
                 TTSEEEEEEEEESSHHHHHHHHHHHTTEEET CS
       RRM_1  35 tgkskgfafVeFeskedAekAlealngkklg 65 
                 +++    afVeFes e A+  l+++ g+k++
  EFC37797.1 259 RKRDGYLAFVEFESVEKAQMFLDKFEGQKIK 289
                 4455557********************9987 PP

  == domain 3  score: 24.4 bits;  conditional E-value: 3.3e-09
                 HHHHHHHHHTTSCEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTE CS
       RRM_1  12 eeeLkelFskfGpiksiklvrdetgkskgfafVeFeskedAekAlealngk 62 
                  + L  lFskfG i++i+++ +   +      V+F+s  +A++A++++ g 
  EFC37797.1 354 VDLLFNLFSKFGTIEKINIFIK---NELTQSLVQFKSDTEATEAVKEMEGV 401
                 5889*****************7...99999******************994 PP

  == domain 4  score: 26.4 bits;  conditional E-value: 7.7e-10
                 EEEESETTTSSHHHHHHHHHTTSCEEEEEEEEE.TTTSEEEEEEEEESSHHHHHHHHH CS
       RRM_1   1 lfVgnLppdvteeeLkelFskfGpiksiklvrd.etgkskgfafVeFeskedAekAle 57 
                 ++V+nLp  +t + L  lF+ +G++ +++++   +++k+  +af++F+ + +  +Al+
  EFC37797.1 623 VIVKNLPVQCTCDHLFVLFGLYGDVIKVSISLSkKDHKTPYMAFIQFKYPHEVGNALR 680
                 68***********************9998888889****************9999987 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 0.86
                 EESETTTSSHHHHHH CS
       RRM_1   3 VgnLppdvteeeLke 17 
                 ++n++ ++te+++++
  EFC37797.1 781 ISNVSGTTTEDKIRR 795
                 8999999****9986 PP

  == domain 6  score: 4.4 bits;  conditional E-value: 0.0055
                 TSEEEEEEEEESSHHHHHHHHHHHTTEEETTEE CS
       RRM_1  36 gkskgfafVeFeskedAekAlealngkklggre 68 
                  k k+ a++e++s ++A+  l +l+   ++++ 
  EFC37797.1 831 MKEKKSAIIEMDSIDAATTVLVELHDISIDSHH 863
                 467999*******************99999875 PP

>> RRM_5  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   0.2   3.4e-11   2.1e-07      39     103 ..     352     421 ..     342     437 .. 0.89
   2 !   26.8   0.0     5e-10     3e-06      13      66 ..     607     659 ..     592     681 .. 0.78
   3 ?   -2.8   0.0      0.72   4.3e+03      86      99 ..     703     716 ..     702     744 .. 0.81
   4 ?    3.1   0.2     0.011        66      61     102 ..     832     872 ..     829     890 .. 0.84

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 3.4e-11
       RRM_5  39 vnldklFnlfclYgnvervk.flktkketalvqmgdasaveravqHLnnaklfgk....rlevalSKqqa 103
                 +n+d lFnlf+ +g +e++  f+k+   ++lvq  + +++  av+ ++++ ++ +    r+++++SK+  
  EFC37797.1 352 LNVDLLFNLFSKFGTIEKINiFIKNELTQSLVQFKSDTEATEAVKEMEGVFVYPEmklyRMNIQFSKKSR 421
                 799****************8467999999************************9888999*******875 PP

  == domain 2  score: 26.8 bits;  conditional E-value: 5e-10
       RRM_5  13 aatgspgaagvaegsVllVyglepdkvnldklFnlfclYgnvervkflktkket 66 
                    ++++    ++  V++V +l p ++++d+lF lf+lYg+v +v +  +kk+ 
  EFC37797.1 607 VPPPMHMPMFPPGTCVVIVKNL-PVQCTCDHLFVLFGLYGDVIKVSISLSKKDH 659
                 333333333347899*******.5679********************9999986 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 0.72
       RRM_5  86 naklfgkrlevalS 99 
                 + +lfgk+l++ +S
  EFC37797.1 703 GSTLFGKELHIEPS 716
                 7789*****99988 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.011
       RRM_5  61 ktkketalvqmgdasaveravqHLnnaklfgkrlevalSKqq 102
                 k  k  a+++m +  a+ + +  L ++++  ++l++++S + 
  EFC37797.1 832 KE-KKSAIIEMDSIDAATTVLVELHDISIDSHHLNIKFSNRS 872
                 44.4579**********************888*******875 PP

>> BRAP2  BRCA1-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.1    0.0011       6.8      43      72 ..     258     287 ..     208     294 .. 0.85
   2 ?   -2.8   0.0       1.2   7.4e+03      51      70 ..     381     400 ..     365     402 .. 0.79
   3 ?    2.3   0.0     0.032   1.9e+02       9      59 ..     622     673 ..     618     689 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0011
       BRAP2  43 dgkenrymvLikfkdqesadeFykefngkk 72 
                 + k++ y + ++f++ e+a+ F ++f+g+k
  EFC37797.1 258 KRKRDGYLAFVEFESVEKAQMFLDKFEGQK 287
                 456679**********************97 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.2
       BRAP2  51 vLikfkdqesadeFykefng 70 
                  L++fk+ ++a e  ke++g
  EFC37797.1 381 SLVQFKSDTEATEAVKEMEG 400
                 58999999999998888776 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.032
       BRAP2   9 llcilavPsylsladllkFvgsvlekvs.eiriirdgkenrymvLikfkdqe 59 
                 ++++  +P + +++ l+ ++g + + ++ +i + ++ ++  ym+ i+fk  +
  EFC37797.1 622 VVIVKNLPVQCTCDHLFVLFGLYGDVIKvSISLSKKDHKTPYMAFIQFKYPH 673
                 567778999*******999999998886356677799999********9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (918 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2048  (0.114228); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.08u 0.36s 00:00:01.44 Elapsed: 00:00:00.56
# Mc/sec: 4934.07
//
Query:       EFC37798.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       761  (0.0424452); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2838.71
//
Query:       EFC37799.1  [L=365]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-76  257.5   0.0    2.5e-76  257.2   0.0    1.1  1  Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase famil
     0.0092   15.1   0.1       0.38    9.8   0.0    2.5  2  Dus           Dihydrouridine synthase (Dus)


Domain annotation for each model (and alignments):
>> Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  257.2   0.0   2.8e-80   2.5e-76       2     339 ..       9     348 ..       8     350 .. 0.92

  Alignments for each domain:
  == domain 1  score: 257.2 bits;  conditional E-value: 2.8e-80
                   CCS-EEETTEEESSSEEE----S-TTTTTCS.HHHHHHHHHHHHHHTT-SEEEEEEEESSCCC-SCTTSEE-SSGGGHHHHHHHHHHHHHTT-EEEE CS
  Oxidored_FMN   2 LFkPikignmtLknRivmapmtrlraldkgnvledlaaeyysqraeipvtliiteaafvnpksggfdnapgiwdeeqieewrklteavhengskvvv 98 
                   LF+Pi+i  mtLknRiv+apm++++++d    ++ +   + + r  ++ +l i ea+ v++ +++ +n  g++++e++e +++++++ he g+k+++
    EFC37799.1   9 LFEPITIRGMTLKNRIVVAPMCQYSCNDGF--ANTWHQIHATSRIVGGAALFIMEATGVSAIGRISPNCLGLYKDEHVEMLKTIVDQSHELGGKIGI 103
                   9*************************9755..7779999********************************************************** PP

                   EEE--GGGS..SCSTCEC..............SS.ESSSSSTTT-.S...CS-EE--HHHHHHHHHHHHHHHHHHHHTT-SEEEEEE-CTSHHHHHH CS
  Oxidored_FMN  99 qlwhlGreakseyladqe............vdspsdpvaldaqeeesaeevykkeltkeeikqliqefveAAkraieAgfDgVeihganGYLlnqFl 183
                   ql+h+Gr+a    l d +            v++ps + ++d+      ++ +++e+t  ei+++i++f eAAkra++AgfD++eihga+GYL++ F+
    EFC37799.1 104 QLAHAGRKASLGRLWDSGrlalsedrggweVVGPS-ELQFDDI-----HK-MPREITIPEIEETIKDFIEAAKRAVKAGFDVIEIHGAHGYLIHSFM 193
                   *********99999888888898866666666666.3333333.....33.489******************************************* PP

                   -TTT----STTSSSHHHHHHHHHHHHHHHHHHH-SSS.EEEEEECE--STTS--HHHHHHHHHHHCHCCEEEEEEETT-SSSSSTTS-TTTTHHHCC CS
  Oxidored_FMN 184 spksnkrtDeygGslenRarFllevvdaVkeavgeer.vgyRlSpedvvekgldfaetaqkivllkelekrlkdgkklalvhaaeprkrgagsvrte 279
                   sp sn rtD ygGs enR r ll +vd V+ ++ ee+ +++RlS ed++e+g ++ +t +  ++lk+ +++l+d++ +    +++    +   v+  
    EFC37799.1 194 SPVSNLRTDMYGGSFENRTRLLLQIVDGVRGVIPEEMpLFVRLSCEDYMEEGWTSDDTVKVSQILKDHGVDLIDCSTGGTKPIQN---VHGLVVEPG 287
                   ****************************************************************************999877776...455566777 PP

                   TT.HHHHHHCCCHSSEEEE-SS--SHHHHHHHHHTTS-SEEEESTHHHH-TTHHHHHHCCT CS
  Oxidored_FMN 280 qe.kntefvkevwkkplitvgriadeekaaeivaegeadLvamgRefladpdlveklkkgl 339
                   ++ k    +ke ++  + +vg+ +d+  a+++ +e++adLv +gR+++ dp ++ +++k l
    EFC37799.1 288 YQvKYSVAIKEKVDILTGAVGKLEDPILANKVIEEKKADLVLIGRAMMGDPYWALRAAKTL 348
                   9989999************************************************999865 PP

>> Dus  Dihydrouridine synthase (Dus)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.3   0.0     0.008        72     133     159 ..     157     183 ..     149     186 .. 0.89
   2 !    9.8   0.0   4.2e-05      0.38      97     223 ..     202     341 ..     194     354 .. 0.63

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.008
                 SSTTTC.HHHHHHHHHHCT-SEEEEES CS
         Dus 133 iddeeenalelakiveaaGaqaltvHg 159
                 i+++ ++ +e+ak++ +aG + + +Hg
  EFC37799.1 157 IEETIKDFIEAAKRAVKAGFDVIEIHG 183
                 6678889999****************8 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 4.2e-05
                 EEEGGGGGGSHHHHHHHHHHHHCCSS..S-EEEEEESESS....TTTC.HHHHHHHHHHCT-SEEEEESS..ECCCTT-C...G--CH..HHHHHHHH- CS
         Dus  97 ggaGaaLlrkpdlvaqivkavvkave..iPvtvkirigid....deeenalelakiveaaGaqaltvHgR..traqnyeg...tadwe..aIkevkqav 182
                  ++G ++ +  +l+ qiv  v+  ++  +P+ v+ +         ++++++++ +i+++ G++ +        + qn +g   +  ++     ++k++v
  EFC37799.1 202 DMYGGSFENRTRLLLQIVDGVRGVIPeeMPLFVRLSCEDYmeegWTSDDTVKVSQILKDHGVDLIDCSTGgtKPIQNVHGlvvEPGYQvkYSVAIKEKV 300
                 56666666666666666666666666444444444443334323345666777777777777766433222133455554433222220022369999* PP

                 SS-EEEESS--SHHHHHHHHHHH--SEEEESCHHCCSTTHH CS
         Dus 183 sipviaNGdIkdaedaqaileetGadgvmigrgalgnPwlf 223
                  i   a G  +d+  a++++ee  ad v+igr+  g+P+  
  EFC37799.1 301 DILTGAVGKLEDPILANKVIEEKKADLVLIGRAMMGDPYWA 341
                 **************************************865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (365 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       430  (0.0239835); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2265.77
//
Query:       EFC37800.1  [L=637]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-06   28.6   1.5    3.5e-06   27.3   1.5    1.7  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
       0.15   12.0   0.1       0.15   12.0   0.1    3.8  4  NdhL      NADH dehydrogenase transmembrane subunit


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   1.5     4e-10   3.5e-06       2      91 ..     515     621 ..     514     636 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 4e-10
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHH..HHHHHHHCSS............... CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklr..eelekrleke............... 83 
                 le++l+++     + eF +++++ en+  +++++ +k+  +q   kk+a+ I ++yl + +p eln++++ +  + +  +le +               
  EFC37800.1 515 LEKVLKNKRMFAKLLEFSRKSYCPENILCFKDIQIYKRL-KQPGKKKMADYICQTYLRQFAPLELNMPHSETryDDIMGKLERKetleknlfdylsvtc 612
                 899************************************.***************************99754125778888777755555555444444 PP

                 .STTTTTTH CS
         RGS  84 .qpsrklfe 91 
                  ++++++fe
  EFC37800.1 613 lNNMQDVFE 621
                 444444444 PP

>> NdhL  NADH dehydrogenase transmembrane subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.4     0.015   1.3e+02      16      47 ..     162     195 ..     154     198 .. 0.72
   2 ?   12.0   0.1   1.7e-05      0.15       9      65 ..     343     399 ..     336     408 .. 0.91
   3 ?   -1.3   1.8      0.25   2.2e+03      14      57 ..     410     454 ..     402     460 .. 0.57
   4 ?   -3.1   0.0      0.86   7.7e+03      49      59 ..     465     475 ..     460     486 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.015
        NdhL  16 ylalsvlYllviPlilylwl.r.kRWyvaskiEr 47 
                  ++ ++++++++Pli++  l r  R y++ k+ +
  EFC37800.1 162 CALFALTFFIIVPLIIIPTLlRsVRLYCMFKLNM 195
                 5678899*******99854423247777776665 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 1.7e-05
        NdhL   9 tllvllaylalsvlYllviPlilylwlrkRWyvaskiErlliymlvflfFPGlllla 65 
                 +l+ l++  ++ ++Y ++iP  l +wl     + + +Er      vfl   Gll+++
  EFC37800.1 343 ILTFLTSNKFIVITYAVLIPIHLAFWLVLGGIEEGIFERDPTQKRVFLEDGGLLMFS 399
                 566777888999*******************************************98 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.25
        NdhL  14 laylalsvlYllv.iPlilylwlrkRWyvaskiErlliymlvflf 57 
                 + + + +vlY+l  i l+++  +  R + + kiE+ ++ ++ f f
  EFC37800.1 410 IIIVVQAVLYILAeIILLIFCVFADRDTWKIKIETFVVVIFQFTF 454
                 334444566666434556666667777777777776554444433 PP

  == domain 4  score: -3.1 bits;  conditional E-value: 0.86
        NdhL  49 liymlvflfFP 59 
                 +iy+l+ ++FP
  EFC37800.1 465 VIYTLIEFIFP 475
                 68888888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (637 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1701  (0.0948742); expected 358.6 (0.02)
Passed bias filter:                      577  (0.0321825); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.80u 0.32s 00:00:01.12 Elapsed: 00:00:00.50
# Mc/sec: 3813.06
//
Query:       EFC37801.1  [L=191]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       353  (0.0196888); expected 358.6 (0.02)
Passed bias filter:                      255  (0.0142228); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 1254.52
//
Query:       EFC37802.1  [L=593]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00014   21.7   0.3    0.00033   20.5   0.3    1.6  1  F-box_4   F-box
     0.0037   17.1   1.1      0.011   15.6   0.2    2.2  2  F-box     F-box domain
  ------ inclusion threshold ------
      0.011   16.3   0.0      0.033   14.8   0.0    1.8  1  Ank_2     Ankyrin repeats (3 copies)
      0.035   14.7   0.0         14    6.4   0.0    2.9  2  Ank_4     Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.3   7.3e-08   0.00033       2      78 ..      28     105 ..      27     118 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 7.3e-08
     F-box_4   2 edsLssLPlevlqhiaslLDsfs.LsqLslvskllrevcssllqergiVllkWekkkysk..gksswkikkkvwefstlf 78 
                 e++Ls L  +v+q i+s+L  +  L+qL +vs+   ++c+s ++e     l W+ k+ s+  g    k +kk w+f++  
  EFC37802.1  28 ENQLSPLGSDVMQLILSFLQPIPfLFQLKRVSSNWNKLCESCMKESC-TELYWDEKTASSllG-NLKKHAKKLWQFPEFY 105
                 5799****************996489*****************9865.688998888877544.445677789***9865 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.2   2.4e-06     0.011       6      39 ..      34      68 ..      30      71 .. 0.92
   2 ?   -2.0   0.0       0.8   3.6e+03      11      21 ..     515     525 ..     515     526 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.4e-06
                S-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTT CS
       F-box  6 LPsevlrhILerLplsd.llalrrVSkgwrilids 39
                L s+v+  IL++L ++  l+ l rVS +w++l+ s
  EFC37802.1 34 LGSDVMQLILSFLQPIPfLFQLKRVSSNWNKLCES 68
                789******************************87 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.8
                 HHHHHHTS-HH CS
       F-box  11 lrhILerLpls 21 
                 l +IL +Lp++
  EFC37802.1 515 LIEILDKLPTV 525
                 679******86 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0   7.3e-06     0.033      13      74 ..     479     562 ..     444     569 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 7.3e-06
       Ank_2  13 vklLl.egadpn.k..ngktaLhyAakngnleivklLle......h.........ad...ndgrtpLhyAarsghleivklLle 74 
                 ++ ++ +++ +n k  +g t+ hy a+ gn  +++ L+e                ++   n+g+t+ +++  ++ +e++++L++
  EFC37802.1 479 FEKMVkHKVHFNaKdrEGSTIAHYLAQVGNGSTLQKLIEildklpTveerkyfldLNipnNQGQTAAMICYNEKKFELLEYLMQ 562
                 45555433444452479**********98889999999866655515556678662255599********988999******84 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0031        14      21      55 .]     483     516 ..     476     516 .. 0.90
   2 ?    5.0   0.0    0.0084        38      24      54 ..     531     560 ..     526     561 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0031
       Ank_4  21 lekgadinaqdnrsGetalhiAakrgnveilklLl 55 
                 + +++  na  +r+G t  h+ a+ gn + l+ L+
  EFC37802.1 483 VKHKVHFNAK-DREGSTIAHYLAQVGNGSTLQKLI 516
                 578999***9.****************99999887 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0084
       Ank_4  24 gadinaqdnrsGetalhiAakrg.nveilklL 54 
                   d+n   n++G+ta  i+ +++ ++e l++L
  EFC37802.1 531 FLDLNIP-NNQGQTAAMIC-YNEkKFELLEYL 560
                 5799998.**********9.777579999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (593 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       724  (0.0403815); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 3527.12
//
Query:       EFC37803.1  [L=640]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-09   35.5   0.2    1.7e-08   34.8   0.2    1.4  1  RGS       Regulator of G protein signaling domain
     0.0059   17.3   5.5     0.0059   17.3   5.5    3.7  3  DUF4282   Domain of unknown function (DUF4282)
  ------ inclusion threshold ------
      0.068   13.4   0.0       0.15   12.3   0.0    1.5  1  Phasin_2  Phasin protein
          7    7.5  21.6      0.043   14.6   3.3    3.4  3  HXXEE     Protein of unknown function with HXXEE motif


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.8   0.2   3.8e-12   1.7e-08       2     102 ..     485     612 ..     484     623 .. 0.90

  Alignments for each domain:
  == domain 1  score: 34.8 bits;  conditional E-value: 3.8e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-H..HHHHHHHHHHCSS............... CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidk..klreelekrleke............... 83 
                 le++l++++  ++  +F +++++ e +  w ++++++ a++++ +kk++  I+  yl  ++p eln+++  kl++e+ ++++                 
  EFC37803.1 485 LEKILKNKKTFQVMLDFARRSYCTESILCWRDIQRYRLARKKSHRKKAIIHILGVYLTFGAPLELNMPNveKLKQEILAQITGGkfivteglivdanei 583
                 89***************************************************************99852255555555555559************** PP

                 ..........STTTTTTHHHHHHHHHHHH CS
         RGS  84 ..........qpsrklfeeaqeevfelle 102
                           q + +lf+++qe++++ ++
  EFC37803.1 584 skimngnalvQLHTNLFQAVQEHCLNDMS 612
                 **************************997 PP

>> DUF4282  Domain of unknown function (DUF4282)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.5   9.8         4   1.8e+04      15      58 ..      99     142 ..      91     191 .. 0.50
   2 !   17.3   5.5   1.3e-06    0.0059       8      67 ..     313     399 ..     309     400 .. 0.75
   3 ?   -3.0   4.6       2.8   1.3e+04      21      61 ..     415     458 ..     411     470 .. 0.50

  Alignments for each domain:
  == domain 1  score: -5.5 bits;  conditional E-value: 4
     DUF4282  15 vlYilgivlialvll.................slivgafaalseslsagggllllllavia 58 
                 vlY+l+++l++++++                 +                  l++ l++vi 
  EFC37803.1  99 VLYLLVVILSGVGVYwkrksghivarnpiylyF-----------------TLGAALFFVIS 142
                 455555555555555333322222222222220.................22222222222 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 1.3e-06
     DUF4282   8 itpkllkvlYilgivlialvll..........slivgafaal.........................seslsagggllllllaviafllmilllR 67 
                 ++ k++ ++Yilg+++ ++v+l          s        +                         ++ + + +g+ ++l++++ f++ i+++R
  EFC37803.1 313 TSLKFITIFYILGFIFGLVVWLiiggieealyS--------FntspdkkriflydgglfvfdhgcgmTSNSIIIVGIEAILYIILEFICFIMCVR 399
                 4679*****************988655555550........3444555555555555566666667567778899*******************9 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 2.8
     DUF4282  21 ivlialvllslivgafaal...seslsagggllllllaviafll 61 
                 iv+ +l +++++v++ +++   ++++ +  g++l+ +++i +++
  EFC37803.1 415 IVIQILSAIIFLVAGNIEFifnFTEYYFPYGFVLWGYMLIEIIV 458
                 33334444444444444446664555555555555555554433 PP

>> Phasin_2  Phasin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   3.4e-05      0.15      53      98 ..     586     631 ..     576     632 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.4e-05
    Phasin_2  53 akdpqellelqselaqpalekavayarklaelaaktqeeaaklaea 98 
                 + + ++l++l++ l+q+++e  + ++ +l+e + + ++e+a+++++
  EFC37803.1 586 IMNGNALVQLHTNLFQAVQEHCLNDMSDLFERLKNSNKEIAEIVKS 631
                 5556789************************************986 PP

>> HXXEE  Protein of unknown function with HXXEE motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   3.3   9.7e-06     0.043      29     109 ..      80     171 ..      43     172 .. 0.76
   2 ?    0.6   0.2      0.21   9.5e+02      29      55 ..     304     337 ..     279     349 .. 0.59
   3 ?    0.7   5.2       0.2     9e+02      34      81 ..     407     458 ..     338     467 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 9.7e-06
       HXXEE  29 e........favavaeefilvlvlvvnallvwli.l.alallakrepllglallafllvnlltHiaqalvlks.YnPGlvTalllflPlaiw 109
                          f++a    f+++++lvv+  +v +      + ++ r+p++  ++l+ +l+ ++  ++ ++v ++ Y  Gl+Ta ++ +P ai+
  EFC37803.1  80 IyglcpdtyFSMAFCLAFVVLYLLVVILSGVGVYwKrKSGHIVARNPIYLYFTLGAALFFVISLTMRVIVGRKiYPCGLLTASFFTFPPAIC 171
                 145555666666666666666666666666655554477777999999999999*****999999999999*****************8875 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.21
       HXXEE  29 e......favavaeefilvlvlvvnallvwli.l 55 
                 +      f +    ++i++++ ++  l+vwli +
  EFC37803.1 304 RklkiynFVTSLKFITIFYILGFIFGLVVWLIiG 337
                 0444444444444456666677777777777643 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.2
       HXXEE  34 vaee.filvlvlvvnallvwli..l.alallakrepllglallafllvnllt 81 
                 +  e + l+++ ++ a++++++  +  ++++ ++   +g++l++++l+++++
  EFC37803.1 407 IKLEsLTLIVIQILSAIIFLVAgnIeFIFNFTEYYFPYGFVLWGYMLIEIIV 458
                 33332333334444444444444445678889999999**********9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (640 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1380  (0.0769703); expected 358.6 (0.02)
Passed bias filter:                      668  (0.0372581); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.76u 0.36s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 3650.05
//
Query:       EFC37804.1  [L=198]
Description: hypothetical protein NAEGRDRAFT_74513 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-73  245.7   0.0    7.5e-73  245.5   0.0    1.0  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  245.5   0.0   4.2e-77   7.5e-73       2     177 ..       5     185 ..       4     188 .. 0.98

  Alignments for each domain:
  == domain 1  score: 245.5 bits;  conditional E-value: 4.2e-77
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 ++v+a+V+DnGs++++aG+ag+daP+av+ps++g+p++++ +      + yvgdea++kr+ l++++p+e+G+v++wd++e++w+h++++el+v peeh
  EFC37804.1   5 EDVQALVVDNGSGMCKAGFAGDDAPRAVFPSIIGRPKQKSIMVgmgnkDAYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH 103
                 689************************************998899**9*************************************************** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGk 177
                 p+llte+plnp+++rek+++i+fE+f vpa+y+a +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G 
  EFC37804.1 104 PVLLTEAPLNPKANREKMTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGF 185
                 ********************************************************************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (198 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       334  (0.018629); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1192.28
//
Query:       EFC37805.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.9e-14   52.3  13.8    5.9e-14   52.3  13.8    2.6  2  Nefa_Nip30_N    N-terminal domain of NEFA-interacting nuclear
  ------ inclusion threshold ------
        1.1    9.0   3.6       0.38   10.5   0.2    1.9  2  Abhydrolase_2   Phospholipase/Carboxylesterase


Domain annotation for each model (and alignments):
>> Nefa_Nip30_N  N-terminal domain of NEFA-interacting nuclear protein NIP30
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.3  13.8   6.6e-18   5.9e-14       7     104 ..      66     160 ..      58     161 .. 0.83
   2 ?    2.6   1.4      0.02   1.8e+02      82      98 ..     210     226 ..     186     238 .. 0.55

  Alignments for each domain:
  == domain 1  score: 52.3 bits;  conditional E-value: 6.6e-18
  Nefa_Nip30_N   7 leeereerqeewekarkeleaerkkeeaeeeedgksLyerLqenkaaKqeefeeklklknqf.raLdedEveFLdeveekkreeeerrkkeeeeele 102
                    ++++++ + +w++  ++ e++   +++eee+d+++LyerL enk +Kq+e e+   + nq+ r+Lded++ +L+e eek ++e+ +  ++e+ee++
    EFC37805.1  66 STSNQQHSNPKWTSLLESRESSL--ADEEEEADTRPLYERLMENKLKKQQELEQV--IGNQApRSLDEDDILYLKEQEEKLKNERLEIINKEKEEIQ 158
                   23444444788888877776662..4445559*********************99..788888********************************** PP

  Nefa_Nip30_N 103 eF 104
                   ++
    EFC37805.1 159 KY 160
                   98 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.02
  Nefa_Nip30_N  82 veekkreeeerrkkeee 98 
                   v+++kr+ e+++kk+++
    EFC37805.1 210 VKKRKRKDENEKKKKKK 226
                   22222222222222222 PP

>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.2   4.3e-05      0.38      52     107 ..      63     118 ..      48     122 .. 0.89
   2 ?   -2.1   0.4       0.3   2.7e+03      77     109 ..     136     168 ..     126     171 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 4.3e-05
                    EEE-GGGTT-EEE-SS-B--SSTTS-B-HHHHHHHHHHHHHHHHHHHHTT--GGGE CS
  Abhydrolase_2  52 elpvtlnggmrmpaWfdlvglspekkedeagikksaekleelidaelkkgipssri 107
                    +  +t n+   +p+W +l +  +++  de+  +++ + +e l +++lkk  + +++
     EFC37805.1  63 SSSSTSNQQHSNPKWTSLLESRESSLADEEEEADTRPLYERLMENKLKKQQELEQV 118
                    5678999999**************************************98766666 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.3
                    -B-HHHHHHHHHHHHHHHHHHHHTT--GGGEEE CS
  Abhydrolase_2  77 kedeagikksaekleelidaelkkgipssriii 109
                    ke+e++ k+   ++ +  ++e++k +++s+i+i
     EFC37805.1 136 KEQEEKLKNERLEIINKEKEEIQKYLQESHIVI 168
                    456666666666666666667777777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3379  (0.188466); expected 358.6 (0.02)
Passed bias filter:                      480  (0.0267723); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 1503.45
//
Query:       EFC37806.1  [L=103]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       729  (0.0406604); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.30s 00:00:00.74 Elapsed: 00:00:00.47
# Mc/sec: 661.06
//
Query:       EFC37807.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      6e-14   52.3  13.8      6e-14   52.3  13.8    2.6  2  Nefa_Nip30_N    N-terminal domain of NEFA-interacting nuclear
  ------ inclusion threshold ------
          1    9.1   3.6       0.37   10.6   0.2    1.9  2  Abhydrolase_2   Phospholipase/Carboxylesterase


Domain annotation for each model (and alignments):
>> Nefa_Nip30_N  N-terminal domain of NEFA-interacting nuclear protein NIP30
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.3  13.8   6.7e-18     6e-14       7     104 ..      66     160 ..      60     161 .. 0.83
   2 ?    2.0   1.9      0.03   2.7e+02      82      98 ..     210     226 ..     186     234 .. 0.54

  Alignments for each domain:
  == domain 1  score: 52.3 bits;  conditional E-value: 6.7e-18
  Nefa_Nip30_N   7 leeereerqeewekarkeleaerkkeeaeeeedgksLyerLqenkaaKqeefeeklklknqf.raLdedEveFLdeveekkreeeerrkkeeeeele 102
                    ++++++ + +w++  ++ e++   +++eee+d+++LyerL enk +Kq+e e+   + nq+ r+Lded++ +L+e eek ++e+ +  ++e+ee++
    EFC37807.1  66 STSNQQHSNPKWTSLLESRESSL--ADEEEEADTRPLYERLMENKLKKQQELEQV--IGNQApRSLDEDDILYLKEQEEKLKNERLEIINKEKEEIQ 158
                   23444445888888877776662..4445559*********************99..788888********************************** PP

  Nefa_Nip30_N 103 eF 104
                   ++
    EFC37807.1 159 KY 160
                   98 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.03
  Nefa_Nip30_N  82 veekkreeeerrkkeee 98 
                   v+++kr+ e+++kk+++
    EFC37807.1 210 VKKRKRKDENEKKKKKK 226
                   22333333333322222 PP

>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.2   4.2e-05      0.37      52     107 ..      63     118 ..      48     122 .. 0.89
   2 ?   -2.0   0.4      0.29   2.6e+03      77     109 ..     136     168 ..     126     171 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 4.2e-05
                    EEE-GGGTT-EEE-SS-B--SSTTS-B-HHHHHHHHHHHHHHHHHHHHTT--GGGE CS
  Abhydrolase_2  52 elpvtlnggmrmpaWfdlvglspekkedeagikksaekleelidaelkkgipssri 107
                    +  +t n+   +p+W +l +  +++  de+  +++ + +e l +++lkk  + +++
     EFC37807.1  63 SSSSTSNQQHSNPKWTSLLESRESSLADEEEEADTRPLYERLMENKLKKQQELEQV 118
                    5678999999**************************************98766666 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.29
                    -B-HHHHHHHHHHHHHHHHHHHHTT--GGGEEE CS
  Abhydrolase_2  77 kedeagikksaekleelidaelkkgipssriii 109
                    ke+e++ k+   ++ +  ++e++k +++s+i+i
     EFC37807.1 136 KEQEEKLKNERLEIINKEKEEIQKYLQESHIVI 168
                    456666666666666666667777777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3434  (0.191533); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 1555.39
//
Query:       EFC37808.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1079  (0.0601818); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 3059.66
//
Query:       EFC37809.1  [L=530]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-23   82.6   3.7    6.6e-07   29.9   0.0    6.8  7  RCC1      Regulator of chromosome condensation (RCC1) repeat
    8.1e-20   70.1   8.8    5.1e-07   29.3   0.0    7.1  7  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.025   14.8   0.1       0.22   11.9   0.0    2.7  2  Kelch_6   Kelch motif


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.85   5.1e+03       2      15 ..      12      25 ..      11      33 .. 0.84
   2 !   10.1   0.0   0.00017         1      32      50 .]      57      75 ..      50      75 .. 0.88
   3 !   17.2   0.0     1e-06     0.006       4      48 ..      81     130 ..      78     131 .. 0.88
   4 !   29.9   0.0   1.1e-10   6.6e-07       2      50 .]     136     204 ..     135     204 .. 0.85
   5 ?    1.9   0.1     0.059   3.5e+02      24      48 ..     250     278 ..     208     280 .. 0.48
   6 ?   -1.7   0.0      0.78   4.7e+03       5      20 ..     349     364 ..     346     384 .. 0.78
   7 !   17.4   0.1   8.8e-07    0.0053       2      49 ..     399     472 ..     398     473 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.85
                TEEEEEE--GGGTT CS
        RCC1  2 GrVysWGrndyGqL 15
                G+++ +G+++++ +
  EFC37809.1 12 GNLFFFGNDSFHHC 25
                999****9987765 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00017
                GTTS-EEEEEEETTEEEEE CS
        RCC1 32 lsgnrvvkvacGddhtval 50
                l+ n+++kva+Gd+h+++l
  EFC37809.1 57 LETNEIIKVASGDFHSLFL 75
                66789***********986 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 1e-06
                 EEEEE--GGGTTSSSS---EEEEEE-GGGTTS.....-EEEEEEETTEEE CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkveglsgn.....rvvkvacGddhtv 48 
                 V   G+n +GqLGl + +    P+ +e   ++     ++  + cG+d+++
  EFC37809.1  81 VIVAGKNKNGQLGLYHFDPIEEPQYLEYVGEErrpcpPIRNIYCGGDYSF 130
                 5566*************99999****88877788**9***********98 PP

  == domain 4  score: 29.9 bits;  conditional E-value: 1.1e-10
                 TEEEEEE--GGGTTSSSS-..--EEEEEE-...........GGGTTS..........-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt..esvlvPtkv...........eglsgn..........rvvkvacGddhtval 50 
                  ++ys+G+n  Gq G+g+   ++v++Pt+v           +   +           +v+ ++cG++ t+ l
  EFC37809.1 136 HHIYSFGKNKIGQIGIGDCmnQRVSIPTRVsiqqkattngsS---SSsstlipgenlPVKLISCGWQSTFIL 204
                 579****************9777799****999888885432...3355799999**************975 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.059
                 EEEEE-.GGGTTS...-EEEEEEETTEEE CS
        RCC1  24 lvPtkv.eglsgn...rvvkvacGddhtv 48 
                 ++P +  ++l++n    ++++  G +ht 
  EFC37809.1 250 DIPNLYaSSLKNNtknSIQDIQVGLFHTG 278
                 33433322233335558888999988885 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 0.78
                 EEEE--GGGTTSSSS- CS
        RCC1   5 ysWGrndyGqLGlgtt 20 
                 y  G n  G LG g++
  EFC37809.1 349 YVSGVNYCGSLGVGSD 364
                 777999999***9987 PP

  == domain 7  score: 17.4 bits;  conditional E-value: 8.8e-07
                 TEEEEEE--GGGTTSSSS-.--E...................EEEEE-GGGTTS.....-EEE.EEEETTEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt.esv...................lvPtkveglsgn.....rvvk.vacGddhtva 49 
                 G+Vy +G+n +G L l +t +s+                   + P +v +l+++     +++  ++cG++ht+a
  EFC37809.1 399 GHVYVCGSNCQGELCLDPTtHSCesngkscpcgaddcfrsciSAPARVLLLENEvnkrrNAKLeMSCGSFHTIA 472
                 9***************7776333344555555555555554555****8888778889866656********98 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.0   8.5e-11   5.1e-07       1      30 []      62      91 ..      62      91 .. 0.98
   2 ?    2.7   0.0      0.02   1.2e+02       4      29 ..     122     147 ..     119     148 .. 0.83
   3 !   15.2   0.1   2.3e-06     0.014       1      28 [.     191     218 ..     191     220 .. 0.93
   4 !    8.8   0.0   0.00023       1.4       3      21 ..     269     287 ..     267     288 .. 0.91
   5 ?   -1.5   0.2      0.41   2.4e+03      15      29 ..     343     357 ..     338     358 .. 0.76
   6 !    8.2   0.2   0.00038       2.2       9      29 ..     390     410 ..     387     411 .. 0.84
   7 !    4.3   0.1     0.006        36       4      13 ..     463     472 ..     461     474 .. 0.90

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 8.5e-11
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30
                +++v++Gd+Hs++Lt+d +V   G N +GQ
  EFC37809.1 62 IIKVASGDFHSLFLTRDKRVIVAGKNKNGQ 91
                799**************************9 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.02
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsdG 29 
                 + +G++ s++ te+ +++++G N  G
  EFC37809.1 122 IYCGGDYSFIETEEHHIYSFGKNKIG 147
                 668999999999999*******9755 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 2.3e-06
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsd 28 
                 Vk +s+G+  +++L e+  ++ +G+Ns+
  EFC37809.1 191 VKLISCGWQSTFILFETEQLYVCGDNSH 218
                 677***********************97 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.00023
      RCC1_2   3 svsaGdyHscaLtedGeVl 21 
                 ++  G +H+ +L+++GeV+
  EFC37809.1 269 DIQVGLFHTGILMNSGEVW 287
                 7999**************9 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 0.41
      RCC1_2  15 tedGeVlcWGsNsdG 29 
                 t ++ ++  G N +G
  EFC37809.1 343 THNDVMYVSGVNYCG 357
                 456668999*****9 PP

  == domain 6  score: 8.2 bits;  conditional E-value: 0.00038
      RCC1_2   9 yHscaLtedGeVlcWGsNsdG 29 
                 + ++ +t  G+V+ +GsN  G
  EFC37809.1 390 NRTIMVTKQGHVYVCGSNCQG 410
                 66788999**********776 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.006
      RCC1_2   4 vsaGdyHsca 13 
                 +s+G++H++a
  EFC37809.1 463 MSCGSFHTIA 472
                 69******98 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.3   7.9e+03      15      24 ..      40      50 ..      40      57 .. 0.78
   2 ?   11.9   0.0   3.7e-05      0.22       7      42 ..     394     423 ..     392     429 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.3
     Kelch_6 15 YifGGytds.s 24
                Y+fG +td+ +
  EFC37809.1 40 YYFGASTDAqF 50
                99****99654 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 3.7e-05
     Kelch_6   7 lvsvggkiYifGGytdsspylnkvwvydpetksWeq 42 
                 +v+ +g++Y++G +++        +++dp t+s+e 
  EFC37809.1 394 MVTKQGHVYVCGSNCQ-----GE-LCLDPTTHSCES 423
                 799*************.....99.899999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (530 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       871  (0.0485805); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.24s 00:00:00.89 Elapsed: 00:00:00.44
# Mc/sec: 3634.66
//
Query:       EFC37810.1  [L=1013]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-49  168.4   0.1    3.9e-49  167.4   0.1    1.6  1  Pkinase         Protein kinase domain
    6.3e-21   74.8   0.0    1.5e-20   73.6   0.0    1.5  1  Pkinase_Tyr     Protein tyrosine kinase
    0.00021   20.9   1.8     0.0004   20.0   0.6    2.2  2  Choline_kinase  Choline/ethanolamine kinase
     0.0052   16.7   0.0     0.0085   16.0   0.0    1.3  1  APH             Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  167.4   0.1   8.7e-53   3.9e-49       3     264 .]     546     859 ..     544     859 .. 0.90

  Alignments for each domain:
  == domain 1  score: 167.4 bits;  conditional E-value: 8.7e-53
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS......CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH.HHSS CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk......hpnivrlyevfeekdelylvleyveggeladlle.rkgs 94 
                 ++e +G+GsfG V+ka++  +++ vAvK+ik++ + ++   +++ Ei +lk l+       +nivr++++f  k++l++v+e+++ + l dll+ ++ +
  EFC37810.1 546 VEEIMGKGSFGIVVKAYDCVNDESVAVKIIKNKPQFHS---QAQIEIGLLKDLNskdtdgKNNIVRMKHYFAWKNHLCIVFELLSMN-LYDLLKaTNFN 640
                 6899***************************9988874...5799******99976666678***********************77.99999954444 PP

                 .--HHHHHHHHHHHHHHHHHHH..HTTEE-SS-SGGGEEEETTTE..EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHH CS
     Pkinase  95 .lseeeakkiakqilegleylH..skgiiHrDlKpeNiLidekge..lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvily 188
                  +s  ++ ++ k++l+ l +l   + ++iH+DlKpeNiL++++++  +K++DFG ++ ++++  + +++ ++ Y++PEv+ + +y++++D+Ws+G+il+
  EFC37810.1 641 gISLLRIYRFGKELLRTLCFLSrpDVQVIHCDLKPENILLKNSKKtsIKVIDFGSSCYVNNK--MYKYIQSRFYRSPEVILGLPYGTEIDMWSYGCILV 737
                 69999999*************955567**************655557*************95..79********************************* PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHHTTS.................................................- CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasei.................................................s 234
                 el tg+p+f    gk+    e+dq++ki+++lg    ++ e++p+++++                                                  
  EFC37810.1 738 ELHTGNPLFD---GKN----EADQIFKIIQLLGmpprKMIEQSPKKDKFfkfnssigqyepldstivpssislydiiinispkrhvspyscpfetfenY 829
                 **********...444....677877888888887766666677777778888889***************************************9888 PP

                 HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 235 eeakdllkkllkkdpkkRltaeellqhpyl 264
                  ++ ++++k+l++dp++Rl  +e lq++++
  EFC37810.1 830 LKLYNVVTKILHYDPQQRLKPAETLQEEFF 859
                 89999*********************9998 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.6   0.0   3.3e-24   1.5e-20       4     213 ..     547     753 ..     545     773 .. 0.80

  Alignments for each domain:
  == domain 1  score: 73.6 bits;  conditional E-value: 3.3e-24
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-......BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklk......hpnivkllgvctkeepllivteyvkgGdLlkfLrkk 95 
                  ++ +G+G+fG Vv+++       ++++VavK++k++ + +  ++   e+ ++k+l+      ++niv++      +++l+iv+e+++  +L + L+++
   EFC37810.1 547 EEIMGKGSFGIVVKAYDC----VNDESVAVKIIKNKPQFH--SQAQIEIGLLKDLNskdtdgKNNIVRMKHYFAWKNHLCIVFELLSM-NLYDLLKAT 637
                  5789***********988....7899*******8765554..3444466666665312222268**********9**********987.8******** PP

                  CTTTSBHHHHHHHHHHHHHHHHHHHH..TTEEEST-SGGGEEEEE..TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHH CS
  Pkinase_Tyr  96 ekekltlkdllsfalqvAkGmeyLes..kklvHrdlaarNvLlse..nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvW 189
                  + + ++l ++++f  ++ + + +L++   +++H dl   N+Ll++  ++ +k+ DfG +  ++++ + +       +  + +pE++    + ++ D+W
   EFC37810.1 638 NFNGISLLRIYRFGKELLRTLCFLSRpdVQVIHCDLKPENILLKNskKTSIKVIDFGSSCYVNNKMYKY-----IQSRFYRSPEVILGLPYGTEIDMW 730
                  ************************9722579************9843569********99993333333.....2334688***************** PP

                  HHHHHHHHHHTTSSGTTTTSHHHH CS
  Pkinase_Tyr 190 sfGvllwEiftlgespypglknee 213
                  s+G +l E+ t g+  + g ++++
   EFC37810.1 731 SYGCILVELHT-GNPLFDGKNEAD 753
                  *********99.776666665444 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.6     9e-08    0.0004      67     176 ..     570     698 ..     561     705 .. 0.57
   2 ?   -3.3   0.0       1.3   5.7e+03      87     138 ..     816     865 ..     809     872 .. 0.67

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 9e-08
                     HHHHHHHHHHHHTTCHH..........TTSSSS-HHHHHHHHH........HHCCS.TT..E...CHHGGCCHCCCTHHHHHHHHHTHHHHHHCH CS
  Choline_kinase  67 iskkiAkklaelHslel.........eseskespslwktmqkw........llnkeaqtkak...kekkkkqlklinledlekelekleklleel 141
                     +  ki k+  ++Hs +          +s  ++ ++   +m+++        ++ +   ++     k ++ + ++l++++++ kel ++      +
      EFC37810.1 570 VAVKIIKNKPQFHSQAQieigllkdlNSKDTDGKNNIVRMKHYfawknhlcIVFELLSMNLYdllKATNFNGISLLRIYRFGKELLRTLC--FLS 662
                     555666666666665555666666663333333333344444444455555333333333330003333445556666666666654444..456 PP

                     GG-EEEE-S--SGGGEEE..-CTTEEEE--GTT-EE CS
  Choline_kinase 142 espvvfcHnDlqegNill.nkeekklvlIDFEYagy 176
                     + +v   H+Dl ++Nill n+++ ++ +IDF  ++y
      EFC37810.1 663 RPDVQVIHCDLKPENILLkNSKKTSIKVIDFGSSCY 698
                     6668889*********994566778******98887 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.3
                     SSSS-HHHHHHHHHHHCCS.TT..ECHHGGCCHCCCTHHHHHHHHHTHHHHH CS
  Choline_kinase  87 skespslwktmqkwllnkeaqtkakkekkkkqlklinledlekeleklekll 138
                     ++  ++ ++t++++   k  +  +k  +++ q +l   e+l++e+ k++++ 
      EFC37810.1 816 VSPYSCPFETFENY--LKLYNVVTKILHYDPQQRLKPAETLQEEFFKINEVA 865
                     55667778888888..666666666666666667777777777777776654 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   1.9e-06    0.0085     164     198 ..     664     698 ..     634     700 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 1.9e-06
                 S-EEEE-SS-SGGGEEEC...TTEEEEE---TT-EE CS
         APH 164 lptvllHgDlhpgNllvd.pddgrvtGviDfedagl 198
                  + +++H+Dl+p N+l++ + ++ +  viDf+ +++
  EFC37810.1 664 PDVQVIHCDLKPENILLKnSKKTSI-KVIDFGSSCY 698
                 4689**************8777776.8****98876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1013 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1060  (0.0591221); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.85u 0.30s 00:00:01.14 Elapsed: 00:00:00.54
# Mc/sec: 5649.74
//
Query:       EFC37811.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.5e-13   51.0   3.5    4.2e-13   50.3   3.5    1.4  1  Metallophos    Calcineurin-like phosphoesterase
    0.00022   21.5   3.9    0.00063   20.0   3.9    1.8  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.3   3.5   4.7e-17   4.2e-13       1     203 [.      81     278 ..      81     279 .. 0.61

  Alignments for each domain:
  == domain 1  score: 50.3 bits;  conditional E-value: 4.7e-17
                  EEEEEEESBTB....TTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSS......HHHHHHHHHHHHHHHH........TSEEEEEC-TTSCHHHH CS
  Metallophos   1 lrilvigDlHl....algggqlddllkllddllreekpdlvllaGDlvdrg......dlekellellaalvky........pipvylllGNHegfeee 80 
                  ++i++++DlH+    +    + +  +++++++l+e kpd+vl++GD+v++       ++ +++l+ ++             ++++y + GNH+ ++ +
   EFC37811.1  81 IKIAQFTDLHYdafeDPPTLPQHLENEMIQKILEE-KPDYVLITGDFVHGEvihssrGIVNDILKPMKI---AlqqihndtKQRIYSVFGNHD-LHTG 173
                  59********6655444444444444777888888.**************9887655333334444433...3455888899999********.4443 PP

                  HHHHHHHHHHHHHHHEHHHCEEETSEEEEEETTE..EEEEEEESECEEETHHHHHHHHHHHSCHHHHCC.HHHHHHHHHHTTCSEEEEEESSESS... CS
  Metallophos  81 llnkygylgifsepwrsdaevfnnlplaslgsgs..lkvlllhGgspellvsldklgslnleleapepg.dewlkdlekrekadwvivlgHsply... 172
                    ++ ++       + + + v++n +  +  ++   + +  +h +       ++++            +  ++++++ k +++ + iv++H+p +   
   EFC37811.1 174 QRHFLKQ----VLEYGNMTVVLDNEYYYDEDNDIviIGLPDYHKD------DFNPV------------RlANLISKNPKITNNSTHIVMSHVPDSasc 249
                  3333333....4444444555555555553333343334444444......11111............126788889999***************443 PP

                  ..CSSSCSCCHHHHHHH..HHHTTESEEEEESSSS CS
  Metallophos 173 ..rgsgylfgdealedl..lkkygvdlvisGHtHv 203
                    +       +  + ++  +k  + d+ + GHtH 
   EFC37811.1 250 liE------KQGKIPKYenCKGVQTDVLLTGHTHA 278
                  332......2222223312334458899******5 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   3.9   7.1e-08   0.00063       2     129 ..      82     278 ..      81     286 .. 0.55

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 7.1e-08
  Metallophos_2   2 klaiiSDlH.snldaleav........lealkevgvdaiihaGD.......leeeep.................evleellela......pvlaVr 58 
                    k+a ++DlH ++++ ++++        ++++ e+++d+++ +GD                              +               +++ V+
     EFC37811.1  82 KIAQFTDLHyDAFEDPPTLpqhlenemIQKILEEKPDYVLITGDfvhgeviH----SsrgivndilkpmkialqQ--------IhndtkqRIYSVF 165
                    789999***97777777777777777788999999*********55555440....1444444344333222212........14444569***** PP

  Metallophos_2  59 GNnD........................eevveedvlreaaelgtdl.......peeaelelagekvlliHgdpl..................... 102
                    GN+D                        e             +++d        p++ +               +                     
     EFC37811.1 166 GNHDlhtgqrhflkqvleygnmtvvldnE-----------YYYDEDNdiviiglPDYHK---------------Ddfnpvrlanlisknpkitnns 235
                    ****5555544444443332222222220...........1111111333333322222...............1234444444444444456666 PP

  Metallophos_2 103 ......gvkdalaellke..........aeegsdvvvcGHtHv 129
                          +v+d+ + l+++          +  + dv++ GHtH 
     EFC37811.1 236 thivmsHVPDSASCLIEKqgkipkyencKGVQTDVLLTGHTHA 278
                    66666666666666666666666555435555569999**996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2473.02
//
Query:       EFC37812.1  [L=120]
Description: ferredoxin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.8e-06   26.8   1.5      5e-06   26.4   1.5    1.2  1  Fer2            2Fe-2S iron-sulfur cluster binding domain
  ------ inclusion threshold ------
      0.063   13.0   0.0      0.099   12.3   0.0    1.3  1  Proteasome_A_N  Proteasome subunit A N-terminal signature


Domain annotation for each model (and alignments):
>> Fer2  2Fe-2S iron-sulfur cluster binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   1.5   5.6e-10     5e-06       4      77 ..      13      94 ..      10      95 .. 0.78

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 5.6e-10
                TTEEEEEEEETTTHBHHHHHHHTTTTTST..TSSSSSS.SSTTEEEEEESCE.....CTT...SSSSTHHHHHTTEEEEGGGSEE CS
        Fer2  4 dgkevevevadgettlldaaeenggidip..ysCgggg.CgtClvevlegev.....qsd...etelegeeldegklrlaCqtiv 77
                +gk ++v++  get l+d  +++ gi +     C g + C  C+v v   +        +   ++ le+++   +  rlaCq+iv
  EFC37812.1 13 EGKVHQVPAYVGET-LMDSIRRA-GINLVpdSTCLGECaCVGCHVIVSNDHEhkltqC-SedeAEILEDAPFVHENSRLACQIIV 94
                68889999999***.99999998.666642378************9987777766531.245677888888777777******98 PP

>> Proteasome_A_N  Proteasome subunit A N-terminal signature
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   1.1e-05     0.099       4      17 ..       6      19 ..       6      19 .. 0.95

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.1e-05
  Proteasome_A_N  4 slttFSPdGRLfQV 17
                    ++t+F  +G+++QV
      EFC37812.1  6 NITVFDREGKVHQV 19
                    59***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (120 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.37u 0.25s 00:00:00.62 Elapsed: 00:00:00.42
# Mc/sec: 857.36
//
Query:       EFC37813.1  [L=423]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-18   66.2   0.0    3.2e-18   65.3   0.0    1.5  1  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.3   0.0   1.8e-22   3.2e-18       2      70 .]     142     209 ..     141     209 .. 0.98

  Alignments for each domain:
  == domain 1  score: 65.3 bits;  conditional E-value: 1.8e-22
                 EEESETTTSSHHHHHHHHHTTSCEEEEEEEEE.TTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEEE CS
       RRM_1   2 fVgnLppdvteeeLkelFskfGpiksiklvrd.etgkskgfafVeFeskedAekAlealngkklggrelk 70 
                 f+gnL++++t+++L+++F++  pi +i+l++d et+++kg+++VeF++ ed + A++ lng  ++gr +k
  EFC37813.1 142 FIGNLSFNATKDDLSDFFGESSPI-NISLPKDkETQRPKGYGYVEFDTVEDLKLAIS-LNGSDFMGRSIK 209
                 9***********************.********************************.*********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (423 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1660  (0.0925874); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 2591.19
//
Query:       EFC37814.1  [L=135]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-12   45.5   0.0    8.9e-12   45.0   0.0    1.2  1  MRPL52    Mitoribosomal protein mL52


Domain annotation for each model (and alignments):
>> MRPL52  Mitoribosomal protein mL52
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.0   0.0     5e-16   8.9e-12       1      68 [.      22      89 ..      22     103 .. 0.92

  Alignments for each domain:
  == domain 1  score: 45.0 bits;  conditional E-value: 5e-16
      MRPL52  1 grkwrlkkglprspneyGpLtdlpDfsfaDGRpapvtsgqlkrkkkqeelakkivkllsEideaeery 68
                g+k+ + +g+ r++ne G L+dlpD+s+ +G p p+++g   ++++++ + +++v+l  E d++ ++ 
  EFC37814.1 22 GQKFYKARGMGRCGNEGGALHDLPDWSYTNGTPGPISHGAEHKQLTRKYFVERVVRLAVEADQDASKL 89
                799999*******************************************************9987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (135 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       306  (0.0170673); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 836.34
//
Query:       EFC37815.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      9e-32  110.1   0.2    1.4e-31  109.5   0.2    1.3  1  Ldh_1_N   lactate/malate dehydrogenase, NAD binding domain
    1.1e-31  110.0   0.0    1.6e-31  109.5   0.0    1.2  1  Ldh_1_C   lactate/malate dehydrogenase, alpha/beta C-terminal
  ------ inclusion threshold ------
       0.05   13.8   0.0       0.13   12.6   0.0    1.6  1  KfrB      KfrB protein


Domain annotation for each model (and alignments):
>> Ldh_1_N  lactate/malate dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.5   0.2   2.3e-35   1.4e-31       1     138 [.       7     152 ..       7     155 .. 0.94

  Alignments for each domain:
  == domain 1  score: 109.5 bits;  conditional E-value: 2.3e-35
                 EEEEEETTTSHHHHHHHHHHHHT.TSSSE....EEEE-SSHH..HHHHHHHHHHHCHCCSTS-EEEEESSGGGGTTESEEEE--S-SS-TTTTHHHHHH CS
     Ldh_1_N   1 vkvavvGaaGgiGqslalllank.klade....laLlDiake..kleGvaldlshistflsvkvkvsekeeealkdadvvvitagvprkpGetRddLlk 92 
                 v+va++GaaG+i++sl   +a++ +l+++    ++L+Di+++  ++eGv+++l++++++l++ + ++++  e +kd+++ +++++ pr +G++R+dLl 
  EFC37815.1   7 VRVAITGAAGQIAYSLIPRIASGeMLGKDqpvhIVLIDIPDSmkVVEGVVMELQDCAFPLVRGITATSDLAEGFKDVEYTLLVGAKPRSKGMERKDLLL 105
                 58*********************899999***********988899***************************************************** PP

                 HHHHHHHHHHHHHHHHT.TTSEEEE-SSSHHHHHHHHHHHHTS-GGG CS
     Ldh_1_N  93 vNakIvkeiveaiakva.pnaivlvvsNPvdiltevlkkasglpkkr 138
                  NakI++++++a+ k+a +n + lvv+NP+++++ ++  ++ +++ +
  EFC37815.1 106 ENAKIFQTQGKALGKHAkSNNLTLVVGNPANTNALIAASNASNIDPK 152
                 *****************999**************9988776655544 PP

>> Ldh_1_C  lactate/malate dehydrogenase, alpha/beta C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.5   0.0   2.7e-35   1.6e-31       1     161 [.     158     321 ..     158     326 .. 0.89

  Alignments for each domain:
  == domain 1  score: 109.5 bits;  conditional E-value: 2.7e-35
                 THHHHHHHHHHHHHHHTS-GGGE.E--EEBSSST..........ETTEEHHHHHTTSTTST.HHHHHHHHHHHHHHHHHHHHHHTTSSSS-HHHHHHHH CS
     Ldh_1_C   1 TtLDivRaktflaekagvtprsv.kvtViGgHsg..........vtiipllsqvkellkls.ekqleeliervqnggdevvkakkGagsatlsmAvAga 87 
                 T+LD+ Ra +++a+k +v  rs  k  ++G+Hs           v      + v+ ++k++  + + e+i++vq++g+++++a+    s+++s+A A++
  EFC37815.1 158 TRLDHDRALAQVANKLKVPVRSLsKFAIWGNHSAtqypdlsyalV------DGVQVSSKVEkTWVESEFIPTVQQRGAAIINARG--SSSAASAADAAI 248
                 9*****************666654**********89886554443......555555555549*********************6..9999******** PP

                 HHHHHHHTTH.TEEEEEEEEEESCCCECCSSEEEEEEEEEEETTEEEEE-------HHHHHHHHHHHHHHHHHHH CS
     Ldh_1_C  88 kfveallrdt.keilsagvyldgevglkdqeieyfsvPvvlgknGvekvleilklndfeeekleksvkeLkkeie 161
                 k+++++  +  +e++s++v +dg +g+k    +y s P+v + nG +++++ lk+++f+++k++ s+keL +e+ 
  EFC37815.1 249 KHMRDWSLGSnGEWVSMAVPSDGSYGIKPG--VYTSYPIVCTGNGKYEIVKDLKIDAFSQNKIDLSIKELLEEKA 321
                 ******776669*****************8..**************************************99865 PP

>> KfrB  KfrB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   2.1e-05      0.13      17      41 ..     258     284 ..     255     286 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.1e-05
        KfrB  17 vggewktekvekagg..lkpgiynlyl 41 
                  +gew+++ v+  g+  +kpg+y+ y+
  EFC37815.1 258 SNGEWVSMAVPSDGSygIKPGVYTSYP 284
                 589********************9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.25s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 2167.32
//
Query:       EFC37816.1  [L=391]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.9e-44  146.8  14.9    1.1e-11   45.0   0.0    8.4  8  Sel1      Sel1 repeat
    2.2e-07   30.4  14.6       0.14   12.4   1.7    7.0  7  TPR_2     Tetratricopeptide repeat
    2.3e-05   24.5   4.2     0.0017   18.5   0.6    3.5  4  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
    6.3e-05   22.9  19.4      0.028   14.6   0.1    6.2  5  TPR_8     Tetratricopeptide repeat
      8e-05   23.2   0.4       0.64   10.7   0.2    3.2  4  TPR_16    Tetratricopeptide repeat
      0.001   18.8  15.2       0.53   10.2   0.0    6.3  7  TPR_1     Tetratricopeptide repeat
     0.0017   18.6   5.4       0.54   10.6   0.1    5.1  4  TPR_12    Tetratricopeptide repeat
     0.0082   16.7   3.3         11    6.9   0.6    4.5  6  TPR_6     Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.01   15.6   0.0       0.12   12.1   0.0    2.3  1  RPN7      26S proteasome subunit RPN7
      0.097   12.5   0.1        3.7    7.4   0.0    2.3  2  DUF992    Protein of unknown function (DUF992)
        1.2    8.9  10.4        3.5    7.4   0.0    4.6  5  TPR_11    TPR repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   1.9e-05     0.031       1      38 []     107     142 ..     107     142 .. 0.89
   2 !   18.3   0.0   1.7e-06    0.0028       7      37 ..     149     177 ..     146     178 .. 0.92
   3 !   13.6   0.1   4.9e-05      0.08       2      35 ..     180     211 ..     179     212 .. 0.91
   4 !    8.1   0.0    0.0027       4.4      21      35 ..     232     246 ..     224     246 .. 0.87
   5 !   21.2   0.0     2e-07   0.00033       1      32 [.     250     279 ..     250     280 .. 0.92
   6 !   45.0   0.0   6.9e-15   1.1e-11       1      38 []     283     318 ..     283     318 .. 0.96
   7 !   12.3   0.1   0.00013      0.22      13      37 ..     323     349 ..     320     350 .. 0.77
   8 !   16.4   0.1   6.5e-06     0.011       2      37 ..     352     386 ..     351     387 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.9e-05
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 + A+++LG  +++  Glg   + ++A+ +y k+A++G+
  EFC37816.1 107 PRALFNLG--EFLVLGLGGRINHKEAFDCYLKSAKLGY 142
                 579*****..66699998777***************96 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 1.7e-06
        Sel1   7 LGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 +G  y+y +Glgv+ D++k +ew+  AA+ G
  EFC37816.1 149 VG--YCYKEGLGVDIDYKKSMEWFVDAANSG 177
                 79..********************9999877 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 4.9e-05
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAe 35 
                  +++ ++   ly +G+g + ++ +A++w  kAA+
  EFC37816.1 180 LSAFEVA--SLYIAGQGCELNVMEALQWALKAAS 211
                 589999*..777*********************7 PP

  == domain 4  score: 8.1 bits;  conditional E-value: 0.0027
        Sel1  21 kDpekAiewyekAAe 35 
                 kD+ek +ew+ kA e
  EFC37816.1 232 KDYEKSLEWLTKASE 246
                 6************86 PP

  == domain 5  score: 21.2 bits;  conditional E-value: 2e-07
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyek 32 
                 +e+ + LG   +ylnG+gv ++++kA+e++e+
  EFC37816.1 250 PESRHWLG--WMYLNGTGVVQNYKKARELFEL 279
                 578899**..********************96 PP

  == domain 6  score: 45.0 bits;  conditional E-value: 6.9e-15
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +e+++rLG   +y+ Glgvp D+ekA+ew+ kAA++G+
  EFC37816.1 283 SESCFRLG--SIYEMGLGVPIDKEKALEWFTKAADMGH 318
                 79******..777************************9 PP

  == domain 7  score: 12.3 bits;  conditional E-value: 0.00013
        Sel1  13 ylnGl.g.vpkDpekAiewyekAAeqG 37 
                 y++Gl   + k ++kA+e++ kAA+q+
  EFC37816.1 323 YMTGLiLlENKEYSKAYEYLLKAANQN 349
                 4677753245569************97 PP

  == domain 8  score: 16.4 bits;  conditional E-value: 6.5e-06
        Sel1   2 eAmyrLGmfylylnGl.gvpkDpekAiewyekAAeqG 37 
                  Am+ +G  +++ +G  gvpk+ ++ ++w++kA ++G
  EFC37816.1 352 NAMHLVG--EMLRDGCkGVPKNASESERWLKKAEKAG 386
                 6999999..866788789***************8887 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       2.9   4.8e+03       2       9 ..     108     115 ..     107     117 .. 0.73
   2 ?    1.5   0.0      0.26   4.2e+02      16      30 ..     126     140 ..     126     143 .. 0.89
   3 !   12.0   0.0   0.00011      0.17       6      31 ..     223     248 ..     218     248 .. 0.87
   4 ?    3.0   0.0     0.083   1.4e+02      15      25 ..     268     278 ..     267     281 .. 0.89
   5 ?   -1.1   0.0       1.8   2.9e+03       2      12 ..     284     294 ..     283     295 .. 0.84
   6 ?    3.6   0.1     0.054        89      16      28 ..     302     314 ..     302     316 .. 0.87
   7 !   12.4   1.7   8.4e-05      0.14       3      33 ..     321     351 ..     320     352 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2.9
       TPR_2   2 ealynlGl 9  
                 +al+nlG+
  EFC37816.1 108 RALFNLGE 115
                 68888885 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.26
       TPR_2  16 dyeeAleafekAlel 30 
                 +++eA +++ k+ +l
  EFC37816.1 126 NHKEAFDCYLKSAKL 140
                 689********9987 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 0.00011
       TPR_2   6 nlGlayyklgdyeeAleafekAleld 31 
                 + G++y+ ++dye+ le++ kA e++
  EFC37816.1 223 MVGKIYLFQKDYEKSLEWLTKASEYN 248
                 6799******************8775 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.083
       TPR_2  15 gdyeeAleafe 25 
                 ++y++A+e+fe
  EFC37816.1 268 QNYKKARELFE 278
                 69*******98 PP

  == domain 5  score: -1.1 bits;  conditional E-value: 1.8
       TPR_2   2 ealynlGlayy 12 
                 e +++lG +y+
  EFC37816.1 284 ESCFRLGSIYE 294
                 679****9996 PP

  == domain 6  score: 3.6 bits;  conditional E-value: 0.054
       TPR_2  16 dyeeAleafekAl 28 
                 d e+Ale+f kA 
  EFC37816.1 302 DKEKALEWFTKAA 314
                 679********96 PP

  == domain 7  score: 12.4 bits;  conditional E-value: 8.4e-05
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPn 33 
                 a y+ Gl+++++++y +A e++ kA   ++ 
  EFC37816.1 321 AQYMTGLILLENKEYSKAYEYLLKAANQNEA 351
                 67999********************998865 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       1.8   2.9e+03      10      33 ..      73     117 ..      65     152 .. 0.59
   2 ?    3.8   0.1     0.041        67      29      49 ..     224     244 ..     197     278 .. 0.67
   3 ?    4.3   0.1     0.029        47       2      58 ..     231     286 ..     230     291 .. 0.78
   4 !   18.5   0.6   1.1e-06    0.0017       7      55 ..     305     352 ..     302     360 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.8
                 HHHHHHH......................HHH--HHHHHHHHHHH CS
      ANAPC3  10 flaerll.....................aaetespedayllAlcl 33 
                  +aerl                      +a++e+p +++ l++ l
  EFC37816.1  73 TFAERLItlrkkgdtvvippliidhikqEAMNENPRALFNLGEFL 117
                 555555544444444444444444444345556666665555544 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.041
                 HHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  29 lAlclylngqykrAyellrka 49 
                  ++ ++ +++y++ +e+l ka
  EFC37816.1 224 VGKIYLFQKDYEKSLEWLTKA 244
                 566677777777777777776 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.029
                 TT-HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHH CS
      ANAPC3   2 qnnyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnskslgc 58 
                 q++y++ + ++ ++   e + pe++++l+  +++     + y+ +r++ +l  +s+ c
  EFC37816.1 231 QKDYEKSLEWLTKAS--EYNLPESRHWLGWMYLNGTGVVQNYKKARELfELSQNSESC 286
                 567888888888888..8999*********9999887777777777776666777666 PP

  == domain 4  score: 18.5 bits;  conditional E-value: 1.1e-06
                 HHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC- CS
      ANAPC3   7 nAiflaerllaaetespedayllAlclylngqykrAyellrka.klnsks 55 
                 +A+ ++ ++   +  + ++ y+ +l l++n++y +Aye+l ka ++n+ +
  EFC37816.1 305 KALEWFTKAA--DMGHKSAQYMTGLILLENKEYSKAYEYLLKAaNQNEAN 352
                 5677777777..8999999************************6665544 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.2      0.58   9.4e+02      16      29 ..     126     139 ..     107     140 .. 0.70
   2 !   14.6   0.1   1.7e-05     0.028       5      31 ..     222     248 ..     218     249 .. 0.89
   3 ?   -1.5   0.1       2.6   4.2e+03      16      25 ..     269     278 ..     268     281 .. 0.82
   4 !    7.6   0.0     0.003       4.9       2      29 ..     284     315 ..     283     316 .. 0.89
   5 !    8.0   2.1    0.0023       3.8       3      32 ..     321     350 ..     320     352 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.58
                 -HHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekale 29 
                 +++eA  +y k  +
  EFC37816.1 126 NHKEAFDCYLKSAK 139
                 67888888888766 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1.7e-05
                 HHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekaleld 31 
                  + g+iyl ++dye++ e++ ka e++
  EFC37816.1 222 EMVGKIYLFQKDYEKSLEWLTKASEYN 248
                 5789*******************9986 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 2.6
                 -HHHHHHHHH CS
       TPR_8  16 dyeeAkeyye 25 
                 +y++A e +e
  EFC37816.1 269 NYKKARELFE 278
                 8999999998 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.003
                 CHHHHHHHHH.HHTT...-HHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiy.lklg...dyeeAkeyyekale 29 
                 e++++lgsiy + lg   d+e+A e++ ka +
  EFC37816.1 284 ESCFRLGSIYeMGLGvpiDKEKALEWFTKAAD 315
                 89********9999999999999999999965 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0023
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldp 32 
                 a y+ g+i+l+ ++y +A ey+ ka   ++
  EFC37816.1 321 AQYMTGLILLENKEYSKAYEYLLKAANQNE 350
                 67888********************87665 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       6.6   1.1e+04      33      42 ..     106     115 ..     105     117 .. 0.79
   2 ?    5.1   0.0     0.022        36      18      60 ..     201     244 ..     200     247 .. 0.83
   3 !    8.6   0.0    0.0018       2.9       3      59 ..     224     279 ..     222     284 .. 0.89
   4 !   10.7   0.2   0.00039      0.64      15      61 ..     305     346 ..     302     353 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 6.6
      TPR_16  33 aaeAllllgd 42 
                 +++Al++lg+
  EFC37816.1 106 NPRALFNLGE 115
                 6789999997 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.022
      TPR_16  18 aaleaalkrdpssPd...aaeAllllgdaalrqgrlaeAaalyraa 60 
                 +al++alk+++s  +    ++A    g ++l q+++++ ++++ +a
  EFC37816.1 201 EALQWALKAASS--VerdIPRAKEMVGKIYLFQKDYEKSLEWLTKA 244
                 578889988843..134699*********************99876 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0018
      TPR_16   3 laraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrq....grlaeAaalyra 59 
                  ++++l ++dy++ ++ l+ a +++      +e++ +lg+++l      +++++A++l++ 
  EFC37816.1 224 VGKIYLFQKDYEKSLEWLTKASEYN-----LPESRHWLGWMYLNGtgvvQNYKKARELFEL 279
                 5899***********9999999999.....99999999999999999999******99986 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00039
      TPR_16  15 dAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraal 61 
                 +A++ ++ a +++     +  A++  g+++l+++++ +A +++++a+
  EFC37816.1 305 KALEWFTKAADMG-----HKSAQYMTGLILLENKEYSKAYEYLLKAA 346
                 4444445555555.....*********************98887765 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.7   2.8e+03       2       8 ..     108     114 ..     107     116 .. 0.78
   2 ?    0.7   0.2      0.33   5.3e+02      16      29 ..     126     139 ..     126     140 .. 0.83
   3 !   10.2   0.0   0.00033      0.53       8      29 ..     225     246 ..     223     248 .. 0.90
   4 ?   -0.4   0.0      0.72   1.2e+03      16      24 ..     269     277 ..     267     279 .. 0.64
   5 ?   -1.5   0.0       1.6   2.5e+03       2      12 ..     284     294 ..     283     295 .. 0.83
   6 ?    2.5   0.1     0.087   1.4e+02      17      27 ..     303     313 ..     302     316 .. 0.87
   7 !    8.4   1.8    0.0012         2       5      28 ..     323     346 ..     320     352 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.7
                 HHHHHHH CS
       TPR_1   2 kalynlG 8  
                 +al+nlG
  EFC37816.1 108 RALFNLG 114
                 7899998 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.33
                 -HHHHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekALe 29 
                 +++eA ++y k  +
  EFC37816.1 126 NHKEAFDCYLKSAK 139
                 689******99765 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00033
                 HHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   8 GnayfklgkydeAleyyekALe 29 
                 G +y+ +++y++ le   kA e
  EFC37816.1 225 GKIYLFQKDYEKSLEWLTKASE 246
                 899****************966 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.72
                 -HHHHHHHH CS
       TPR_1  16 kydeAleyy 24 
                 +y++A e +
  EFC37816.1 269 NYKKARELF 277
                 677776666 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 1.6
                 HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayf 12 
                 +++++lG +y 
  EFC37816.1 284 ESCFRLGSIYE 294
                 6789*****96 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.087
                 HHHHHHHHHHH CS
       TPR_1  17 ydeAleyyekA 27 
                  ++Ale + kA
  EFC37816.1 303 KEKALEWFTKA 313
                 69********9 PP

  == domain 7  score: 8.4 bits;  conditional E-value: 0.0012
                 HHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekAL 28 
                 y  G++++++++y +A ey  kA 
  EFC37816.1 323 YMTGLILLENKEYSKAYEYLLKAA 346
                 5569*****************996 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.56   9.2e+02      18      33 ..     126     141 ..     123     153 .. 0.79
   2 !   10.6   0.1   0.00033      0.54       9      47 ..     224     259 ..     216     282 .. 0.69
   3 ?    0.5   0.0      0.47   7.7e+02      62      74 ..     304     316 ..     302     319 .. 0.72
   4 ?    3.4   0.6     0.058        95      10      34 ..     326     350 ..     320     363 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.56
      TPR_12  18 rydeAlellekaleia 33 
                 ++ eA++++ k+  + 
  EFC37816.1 126 NHKEAFDCYLKSAKLG 141
                 6899999999998776 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00033
      TPR_12   9 laavlrrlgrydeAlellekaleiarrllGpdhpltatt 47 
                 ++ +++ +++y+++le+l ka e    l++  h ++ + 
  EFC37816.1 224 VGKIYLFQKDYEKSLEWLTKASEYN--LPESRH-WLGWM 259
                 6889999999999999999998876..444555.55544 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.47
      TPR_12  62 eeAlelleealai 74 
                 e+Ale++++a ++
  EFC37816.1 304 EKALEWFTKAADM 316
                 7788888887665 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.058
      TPR_12  10 aavlrrlgrydeAlellekaleiar 34 
                 +++l++ ++y +A e+l ka ++ +
  EFC37816.1 326 GLILLENKEYSKAYEYLLKAANQNE 350
                 7889999999999999999987655 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       7.2   1.2e+04       2       8 ..     109     115 ..     108     122 .. 0.81
   2 ?   -2.9   0.0       9.3   1.5e+04       7      14 ..     150     158 ..     148     164 .. 0.77
   3 ?   -0.9   0.0       2.1   3.4e+03       7      21 ..     225     239 ..     223     243 .. 0.85
   4 ?    6.1   0.0     0.012        20       2      24 ..     252     278 ..     251     279 .. 0.90
   5 ?   -2.6   0.0         7   1.1e+04       4      13 ..     287     297 ..     287     308 .. 0.61
   6 !    6.9   0.6    0.0066        11       2      27 ..     321     346 ..     320     349 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 7.2
                 HHHHHHH CS
       TPR_6   2 Alyklal 8  
                 Al++l++
  EFC37816.1 109 ALFNLGE 115
                 9999997 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 9.3
                 HHHHHH.HH CS
       TPR_6   7 alsyrk.lg 14 
                 +++y++ lg
  EFC37816.1 150 GYCYKEgLG 158
                 89**99665 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 2.1
                 HHHHHHHHHHHHHHH CS
       TPR_6   7 alsyrklgdtdkAle 21 
                 ++ y+ ++d++k+le
  EFC37816.1 225 GKIYLFQKDYEKSLE 239
                 88999999***9876 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.012
                 HHHHHHHHHHHH....HHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl....gdtdkAleale 24 
                 +  +l++ y+++    +++ kA+e++e
  EFC37816.1 252 SRHWLGWMYLNGtgvvQNYKKARELFE 278
                 5679*******88************97 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 7
                 HHHHHHHHH.H CS
       TPR_6   4 yklalsyrk.l 13 
                 ++l+  y++ l
  EFC37816.1 287 FRLGSIYEMgL 297
                 78888888744 PP

  == domain 6  score: 6.9 bits;  conditional E-value: 0.0066
                 HHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerli 27 
                 A+y+ +l +++ ++++kA e+l +  
  EFC37816.1 321 AQYMTGLILLENKEYSKAYEYLLKAA 346
                 99*********99*******997765 PP

>> RPN7  26S proteasome subunit RPN7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   7.5e-05      0.12      17     141 ..     201     347 ..     198     356 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.5e-05
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHCT-HHHHHHHHHTCCCC--SHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHCSSS---.HHHHHH. CS
        RPN7  17 eeLdaelkdakenlgkeeirrakldlaehYlkigdleeAlkaysrireyctslkhkidmllnlirvaiffndwdlvskylekakellekggdwerknr. 114
                 e+L+  lk     +++ +i rak+  ++ Yl   d+e++l+++ ++ ey    + +   +l ++     + +   v ++ +ka+el e  ++ e   r 
  EFC37816.1 201 EALQWALKA--ASSVERDIPRAKEMVGKIYLFQKDYEKSLEWLTKASEYNLPESRH---WLGWM-----YLNGTGVVQNYKKARELFELSQNSESCFRl 289
                 567777776..789999********************************9986655...55554.....456666677778888888888886666666 PP

                 ...............................HHHHHHHHHHHTT-HHHHHHHHCTS-G CS
        RPN7 115 ...............................lkvyeGlallairkfkeAaellldils 141
                                                 +   Gl+ll+++++++A e ll++  
  EFC37816.1 290 gsiyemglgvpidkekalewftkaadmghksAQYMTGLILLENKEYSKAYEYLLKAAN 347
                 666666666666666666666666677777788889****************999865 PP

>> DUF992  Protein of unknown function (DUF992)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.0    0.0023       3.7      32      83 ..     125     178 ..     118     202 .. 0.84
   2 ?    2.7   0.0     0.062     1e+02      32      80 ..     267     315 ..     261     326 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0023
      DUF992  32 vgsskelsCvfrsasgk..keekYtgtirklGldlgiteesklawaVlaptakl 83 
                 ++ +++ +C  +sa+    k ++ +g   k Gl ++i  + ++ w V a+++ +
  EFC37816.1 125 INHKEAFDCYLKSAKLGynKGKHLVGYCYKEGLGVDIDYKKSMEWFVDAANSGI 178
                 566788999999998765688999***********************9997665 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.062
      DUF992  32 vgsskelsCvfrsasgkkeekYtgtirklGldlgiteesklawaVlapt 80 
                 v+  k+ +  f+ ++++++    g+i ++Gl + i +e +l w   a+ 
  EFC37816.1 267 VQNYKKARELFELSQNSESCFRLGSIYEMGLGVPIDKEKALEWFTKAAD 315
                 555556666677776666777789*******************987764 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.077   1.3e+02      26      36 ..     105     115 ..     104     118 .. 0.89
   2 ?    7.4   0.0    0.0021       3.5       1      24 [.     225     248 ..     225     262 .. 0.88
   3 ?   -1.8   0.1       1.6   2.6e+03      14      21 ..     267     274 ..     267     276 .. 0.78
   4 ?   -3.5   0.0       5.4   8.8e+03      11      20 ..     304     313 ..     304     315 .. 0.83
   5 ?    1.6   1.5      0.14   2.3e+02       1      28 [.     326     353 ..     326     354 .. 0.93

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.077
      TPR_11  26 dnaeayynLGl 36 
                 +n++a++nLG+
  EFC37816.1 105 ENPRALFNLGE 115
                 7*********6 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0021
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkld 24 
                 G++y  q +ye+++e++ kA +++
  EFC37816.1 225 GKIYLFQKDYEKSLEWLTKASEYN 248
                 899999**************9986 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.6
      TPR_11  14 ieaYkkAl 21 
                 +++YkkA 
  EFC37816.1 267 VQNYKKAR 274
                 689***95 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 5.4
      TPR_11  11 eeAieaYkkA 20 
                 e+A+e++ kA
  EFC37816.1 304 EKALEWFTKA 313
                 7999999888 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.14
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdna 28 
                 G ++ e  +y +A e + kA + ++ na
  EFC37816.1 326 GLILLENKEYSKAYEYLLKAANQNEANA 353
                 789999*****************99997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 2555.32
//
Query:       EFC37817.1  [L=703]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00042   20.5   0.0    0.00088   19.5   0.0    1.5  1  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   4.9e-08   0.00088      65     185 ..     473     622 ..     448     649 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 4.9e-08
      DUF563  65 veklivpvppr..ssggfqgallpklrdrlrerlnlekr.....kkptrvlyisR.lkagsRrilNeeevl........kllpkrg........fevvd 139
                 ++ l+v +p+   +s+  +++l+p +rd +++ ++  ++      ++ ++l+i   +++++  i+N + +         ++l++ +        +e ++
  EFC37817.1 473 FSSLVVGSPDSyfLSPEKRHHLIPVFRDYVLNGMGYVPPrsyfeGRK-KILIIGIlNSSKKESIVNADKLTdylsglakDILQQVNshripddrYESIR 570
                 55666666666667788888888999999999999888778886455.787887777899********9976668888855555556666666655444 PP

      DUF563 140 .....peslsfeeqiklfssakvivgphGsgltnliFm.ppgttvielvppn 185
                      ++++++ +qi+lf   +v+++  G   + ++Fm +p++ vi   + +
  EFC37817.1 571 ilnlkLDDMTVVQQIRLFTVMDVFITNQGLDSYYSLFMyNPRALVIYAPMCF 622
                 4445599*******************************99977777654433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (703 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.30s 00:00:01.05 Elapsed: 00:00:00.52
# Mc/sec: 4097.81
//
Query:       EFC37818.1  [L=443]
Description: alpha-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.5e-53  180.7   0.4    5.7e-53  180.0   0.4    1.3  1  Tubulin    Tubulin/FtsZ family, GTPase domain
    5.1e-27   94.5   0.0    1.1e-26   93.4   0.0    1.6  1  Tubulin_C  Tubulin C-terminal domain
     0.0025   17.5   0.0       0.01   15.6   0.0    1.9  2  Tubulin_3  Tubulin domain
     0.0077   16.1   0.3      0.051   13.5   0.1    2.3  2  DUF2719    Protein of unknown function (DUF2719)


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  180.0   0.4   1.3e-56   5.7e-53       1     197 []       3     209 ..       3     209 .. 0.95

  Alignments for each domain:
  == domain 1  score: 180.0 bits;  conditional E-value: 1.3e-56
                 EEEEEEEHHHHHHHHHHHHH...HHHCH............HHHT.....TTEEEEE....EEESBHHHHHTS-GS.......EEEE--CCCCTTC--TT CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiq.sdg.......dslesfFsesgkveyiprsvaidtdpqvlneikags.elfnpnklllgkegagnngagg 90 
                 eii i++Gq+G+qign++w+ll+ ehgi+ s+g        + + fFses ++++ +r++++d+d++ +++i++g+ ++++ ++l++g+e+++nn+a+g
  EFC37818.1   3 EIISIHIGQAGSQIGNTCWDLLCLEHGIDsSTGakihnhsAADKYFFSESMDGTMRARALFVDLDSEIIDKIRSGNnNIYDGESLISGNENTANNFAKG 101
                 79**************************95555*****977778888899988888******************************************* PP

                 -HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--.GG.G-HHHHHHHHHHHHHHHHT-SEEEEEE CS
     Tubulin  91 ypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs.efsevvvepynailalkelieesdavivid 188
                 +   g+ + e +le+i+k+ve+cd lqgf+it+sl GGTGSG+  +++e+l   ++k+ ++++ +l s +  ++ ve+yn ++++++++e+sda ++++
  EFC37818.1 102 RGVGGNLVLENCLERIEKMVEECDALQGFLITSSLNGGTGSGFRDLLMERLAPGFEKKCKLSFDILASpSSVSSCVESYNVLFGMNSIREYSDASVIVE 200
                 *******************************************************9999999988888755599************************* PP

                 HHHHHCCST CS
     Tubulin 189 NdaLlkiln 197
                 N+aL++i++
  EFC37818.1 201 NEALIDICK 209
                 *******96 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.4   0.0   2.5e-30   1.1e-26       1     125 [.     258     390 ..     258     391 .. 0.95

  Alignments for each domain:
  == domain 1  score: 93.4 bits;  conditional E-value: 2.5e-30
                 TTC-EEEEEEESSSCTT..TTTCS-HHHHHHHHHTCSGG.GBSSSTSTTTSSEEEEEEEEEESSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEEC CS
   Tubulin_C   1 PrlhFlltsyaPlvsae..kaavektsvqdvtrallepk.nimvkvdprkgkylaiallirGdvepkevnkavqrikekkkaqfveWiptgikvalnkk 96 
                 P + +l+ s++Pl+ +e    ++ek +++++t++++  k ++m +++  +gk++ +   +rGd+ ++ v++a+++ik+ ++++fv+W+p+g+k+++ + 
  EFC37818.1 258 PPVKYLINSMSPLYPKEfvFCSYEKPTITELTESCFMDKySVMTNCNLMDGKFMVCTVQYRGDICIRHVSSAIAKIKTSREIKFVDWCPAGFKCGIHDG 356
                 8899*************88889*************965527999******************************************************* PP

                 ECT-TTTS.....SCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C  97 spyvkkqs.....kvsvlmlaNttsiaelfkrll 125
                 +    ++      ++ v ml+N+tsi+++f+r++
  EFC37818.1 357 PLSNIPGGnicyrDRDVNMLSNSTSISQTFSRIE 390
                 **999999999999******************96 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   2.2e-06      0.01      65     179 ..     118     237 ..     106     239 .. 0.72
   2 ?   -1.3   0.1      0.33   1.5e+03      42      74 ..     385     417 ..     368     428 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.2e-06
   Tubulin_3  65 rpfaeecdqlrglqvftgvddaWG.GfaakylerlrdeygkksilvWvlaleeklkkkkkaklerklkklnkarslkelse..qaslyvPiakls...d 157
                  +++eecd l+g+ + ++ +   G Gf    +erl   + kk+ l + + l ++++ ++ ++  + l  +n++r  ++ s   +  +++ i k +   +
  EFC37818.1 118 EKMVEECDALQGFLITSSLNGGTGsGFRDLLMERLAPGFEKKCKLSFDI-LASPSSVSSCVESYNVLFGMNSIREYSDASVivENEALIDICKNKlnvE 215
                 5789***************9988779****************9655544.5667777777777788888888887766544115555666665442122 PP

   Tubulin_3 158 aeseWhtsaLlssalesvtlps 179
                 + +      +++ a+ s+t++ 
  EFC37818.1 216 HPKMTDLNEIIANAISSATISV 237
                 3344555666777777777765 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.33
   Tubulin_3  42 dwsvGeeLfeeldkehdlldrdlrpfaeecdql 74 
                  +s  e+ f+el  e+ ++ r l   aee +  
  EFC37818.1 385 TFSRIEKNFDELYSERSFVHRYLEEGAEEIEFT 417
                 366778889999999999999999999987765 PP

>> DUF2719  Protein of unknown function (DUF2719)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.1   1.1e-05     0.051      18      67 ..     169     219 ..     156     230 .. 0.85
   2 ?   -1.0   0.0      0.37   1.7e+03      44      60 ..     333     349 ..     322     352 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.1e-05
     DUF2719  18 reedvvlcPkcyfvapgeisvadytrlh.ikfneqfadkcsnnlvvtqpkt 67 
                  ++ v  c   y v  g  s+ +y     i  ne ++d c+n+l v++pk 
  EFC37818.1 169 SPSSVSSCVESYNVLFGMNSIREYSDASvIVENEALIDICKNKLNVEHPKM 219
                 5678999*****************997626679****************95 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.37
     DUF2719  44 lhikfneqfadkcsnnl 60 
                 +    + +f+d c+  +
  EFC37818.1 333 IKTSREIKFVDWCPAGF 349
                 55556789*****9877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       465  (0.0259356); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 2984.83
//
Query:       EFC37819.1  [L=1282]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-08   34.3   0.2    1.5e-08   34.3   0.2    4.6  6  E1-E2_ATPase  E1-E2 ATPase
    1.8e-08   34.5   0.0     0.0014   18.5   0.0    2.8  2  Hydrolase_3   haloacid dehalogenase-like hydrolase
    8.8e-05   22.9   0.0       0.89    9.8   0.0    3.2  3  Hydrolase     haloacid dehalogenase-like hydrolase
  ------ inclusion threshold ------
       0.19   12.5   0.3       0.63   10.9   0.0    2.1  2  DUF4512       Domain of unknown function (DUF4512)


Domain annotation for each model (and alignments):
>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.82   3.7e+03     121     144 ..      22      45 ..      20      60 .. 0.56
   2 ?    1.1   0.2     0.053   2.4e+02      90     142 ..      57     107 ..      48     119 .. 0.65
   3 ?   -3.6   1.8       1.5   6.9e+03     123     157 ..     198     232 ..     167     234 .. 0.58
   4 !   34.3   0.2   3.4e-12   1.5e-08      21     166 ..     265     461 ..     246     470 .. 0.86
   5 !    4.2   0.1     0.006        27     113     158 ..    1112    1157 ..    1094    1165 .. 0.83
   6 ?   -4.1   2.3       2.1   9.4e+03     122     159 ..    1232    1268 ..    1221    1274 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.82
                   HHHHHHHHHHHHHHHS-STTTSST CS
  E1-E2_ATPase 121 vlvpvvlliallvflialllgksl 144
                   ++ ++v+ i++++  + ++  ++ 
    EFC37819.1  22 YYLIIVVYIIIICTCFYYIQLDDF 45 
                   555555555555555555544444 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.053
                   TTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTS CS
  E1-E2_ATPase  90 edtelgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgk 142
                   e++ ++   r++e+a   k+ l k ++k   v  pvv++ +++++l+ +++++
    EFC37819.1  57 ESNVFKNSSRHIETA--FKPALGKLAEKTKTVRGPVVFASLIIAILTYIVMNH 107
                   666677777888887..566666666666666666666666666666665555 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 1.5
                   HHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHH CS
  E1-E2_ATPase 123 vpvvlliallvflialllgkslaeallralallva 157
                    p+ ++++++ f+++++   +  ++ l +++l++a
    EFC37819.1 198 QPIQIWCLIISFVQLFVFHTGKSFYPLAVFTLFIA 232
                   35555555555555544444433455545554444 PP

  == domain 4  score: 34.3 bits;  conditional E-value: 3.4e-12
                   GG--TTSEEEEETT-B--SEEEEEE.............E-S...EEE-TTTS---S-EE-............................G-TTEE-TT CS
  E1-E2_ATPase  21 kelvpGDivllkagdrvpaDgrive.............gsa...evdesaLTGEslpvek............................ekgdmvfsG 73 
                    +l++GD vl+  g+  paD ++ +               +    ++e  +TGE+ pv+k                            ++   vf+ 
    EFC37819.1 265 GQLKCGDEVLIGIGEELPADLILTDiivedtdvqfktsR-KpilYMNEVTVTGENDPVKKcllpesvhtikidnllirsatvnskyilDESYIVFAN 360
                   68**********************************962.3457********************************************9******** PP

                   -EEEE..-EEEEEEEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTT......HHHHHHHHHHHHHS-TT CS
  E1-E2_ATPase  74 tvvvs..geakavVtatgedtelgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgksla......eallralallvaaiPca 162
                   +++ s  ++++++ +  ++ te + + ++ ++++++ tp+q+  +k + +  +++l+++++  ++  + g + +      + l+  +  + +++P +
    EFC37819.1 361 SMIASvdQKITIRGIVAWSGTETKALHSSGATTSKQATPFQEYTQKGFFISLALMLFLSIVNTIASSFFGVEGNeehsfgKVLITQIMYINMMVPQG 457
                   ***8888999999999999999999*********************988888888888888777777766666666777777777888888888888 PP

                   HHHH CS
  E1-E2_ATPase 163 Lpla 166
                   L  +
    EFC37819.1 458 LEQL 461
                   8655 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.006
                    HHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHHH CS
  E1-E2_ATPase  113 kkldklgkvlvpvvlliallvflialllgkslaeallralallvaa 158 
                    k  +k++     +++++a+++f+i l+++k + + ++++ al v++
    EFC37819.1 1112 KRTTKISYSRLYLSIFCAVATFAISLFINKRVEDQITKFTALSVII 1157
                    5567777777889999****************99999988888774 PP

  == domain 6  score: -4.1 bits;  conditional E-value: 2.1
                    HHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHHHS CS
  E1-E2_ATPase  122 lvpvvlliallvflialllgkslaeallralallvaai 159 
                    +++++ ++++++fl+++++ ++  +all + +++v+ i
    EFC37819.1 1232 IMTLSGIATVFTFLVFVSRMGFM-RALLDGRSVAVGLI 1268
                    44555555555666655555555.88888888888765 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   1.8e-05     0.081      17      57 ..     745     785 ..     740     792 .. 0.86
   2 !   18.5   0.0     3e-07    0.0014     203     240 ..     893     931 ..     883     938 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.8e-05
                  -HHHHHHHHHHHHTTSEEEEE-SS-HHHHHHHHHHCCCCSE CS
  Hydrolase_3  17 sektkeaikklkekgikvviATGRslravlpvleelgldlp 57 
                   +  ke ik+l  +g +++i+TG s+++++ ++ +l l ++
   EFC37819.1 745 RDGVKEGIKQLTHAGKQFCICTGDSYKNAKLIATHLSLPNH 785
                  567899***************************99998743 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 3e-07
                  GGGEEEEESSGGGHHHHHHSSEEEEETTS-.HHHHHHSS CS
  Hydrolase_3 203 leeviafGDgeNDieMLeaaglgvAmgnas.eevkkaAd 240
                  ++ v+a+GDg ND++ML a+++++ +++++ e v k Ad
   EFC37819.1 893 RNYVLAMGDGTNDLQMLRACDISYGVKSGEtEDVCKQAD 931
                  6779**********************9985144666655 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.046     2e+02       2      17 ..     492     507 ..     491     538 .. 0.80
   2 !    9.8   0.0    0.0002      0.89     115     156 ..     742     781 ..     650     809 .. 0.85
   3 !    6.9   0.0    0.0015       6.7     191     210 .]     894     913 ..     873     913 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.046
                 SEEEEESBTTTBCHHH CS
                 xxxxxxxxxxxxxxxx RF
   Hydrolase   2 ktvvfDkdGTLttgep 17 
                 + ++ Dk+GTLt   +
  EFC37819.1 492 NRIISDKTGTLTVNLM 507
                 66899*******6554 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.0002
                 HTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHHTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 115 dplkvkpeaaeavasLkaagievvlltgdnpetaeraanqlG 156
                 d    +++++e +++L  ag + +++tgd+ ++a+ +a +l 
  EFC37819.1 742 DR--YRDGVKEGIKQLTHAGKQFCICTGDSYKNAKLIATHLS 781
                 55..78999**************************9999877 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0015
                 GGEEEEESSHHHHHHHHHTT CS
                 xxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 191 eevamVGDgvnDaaalaaAg 210
                 + v++ GDg nD+++l+a +
  EFC37819.1 894 NYVLAMGDGTNDLQMLRACD 913
                 4599*************986 PP

>> DUF4512  Domain of unknown function (DUF4512)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00014      0.63       5      45 ..      94     137 ..      90     187 .. 0.61
   2 ?   -3.7   0.1         4   1.8e+04       7      20 ..    1156    1173 ..    1155    1186 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00014
     DUF4512   5 CiiiPlLlyiykkfvePivlryin..Pwekkdaegnvikagp.e 45 
                  +ii +L yi  +++ Pi+l+y+    w k+ +e++ +++ + e
  EFC37819.1  94 SLIIAILTYIVMNHLIPILLNYWVilDWRKNHTEKDELQNKSrE 137
                 68********************9744699999998888765532 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 4
     DUF4512    7 iiPlL....lyiykkfve 20  
                  iiP L    +y++k fv+
  EFC37819.1 1156 IIPTLgypaIYLFKCFVH 1173
                  555554444899999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1282 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1219  (0.0679904); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.00u 0.32s 00:00:01.32 Elapsed: 00:00:00.53
# Mc/sec: 7283.88
//
Query:       EFC37820.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.3e-19   68.5   0.2    6.1e-19   68.1   0.2    1.2  1  Ribosomal_L31e  Ribosomal protein L31e


Domain annotation for each model (and alignments):
>> Ribosomal_L31e  Ribosomal protein L31e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.1   0.2   3.4e-23   6.1e-19       3      77 ..      23      97 ..      21     102 .. 0.94

  Alignments for each domain:
  == domain 1  score: 68.1 bits;  conditional E-value: 3.4e-23
  Ribosomal_L31e  3 vtreytInihkrihgvgfkkraprAlkeikkfamkemgtpdvridtrLnkavwakgirnvpyrirvrlsrkrned 77
                    v+ e t n+h+ + g  +++ra rA+++ik  a+k m+ + v++d++Lnk+vw++gi+n+p+++r  l r  n +
      EFC37820.1 23 VALESTFNLHRELVGKPIQRRAARAVRAIKSHARKVMNCSRVKLDPELNKYVWNQGIHNPPKKVRLILRRMANPN 97
                    77899***************************************************************9988854 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       318  (0.0177366); expected 358.6 (0.02)
Passed bias filter:                      260  (0.0145016); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.32s 00:00:00.78 Elapsed: 00:00:00.49
# Mc/sec: 817.20
//
Query:       EFC37821.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-10   41.1   0.2    2.7e-07   30.5   0.1    3.2  2  DNA_pol_A_exo1  3'-5' exonuclease
  ------ inclusion threshold ------
      0.025   14.4   0.1      0.061   13.1   0.1    1.6  1  Leptin          Leptin
      0.042   13.4   1.3       0.08   12.5   1.3    1.4  1  MscS_porin      Mechanosensitive ion channel porin domain
        0.6    9.8   4.3       0.37   10.5   0.6    2.5  3  DUF1366         Protein of unknown function (DUF1366)
        3.1    8.3   9.2       0.25   11.9   3.8    2.0  2  APG6_N          Apg6 coiled-coil region
        7.5    6.6   9.4       0.61   10.1   0.8    3.0  3  Prefoldin_2     Prefoldin subunit


Domain annotation for each model (and alignments):
>> DNA_pol_A_exo1  3'-5' exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.018        53       8      45 ..      58      93 ..      47     103 .. 0.82
   2 !   30.5   0.1     9e-11   2.7e-07      51     174 ..     167     318 ..     152     320 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.018
                    HHHHHHHHHHTTSSEEEEEEEEE-SSSTTSSEEEEEEE CS
  DNA_pol_A_exo1  8 eeleelieelknlkvvavDtEttsldlisatlvliliq 45
                    +e +e+i+  + ++v+ +DtE  + ++   + +l  iq
      EFC37821.1 58 DEWKEMINDPNVHTVFYLDTEVGGFKT--NSERLSCIQ 93
                    67789999999999********99999..555555555 PP

  == domain 2  score: 30.5 bits;  conditional E-value: 9e-11
                     EEEEEECTTTTTT-HGHHHHHHHT-TTSEEEESSHHHHHHHHHHHHTS--SSEEEH.HHHHHHTTHSTT....SSHHHHHHHHHS...B---GHC CS
  DNA_pol_A_exo1  51 eayiidplelgddvalealkrlledenitkvghnakfDlevlardfgielenlfdt.mlaayvldyers....hsLdsLaekylg...dleldke 137
                     + +i+d l++ dd+  ++  +++ de  +kv+h  +fDl++l    + + +n+ +t +++++ + y       ++Ld+L +++++     + +++
      EFC37821.1 167 KIVILDVLDMSDDLLDYFEDNIMFDERCEKVFHYKTFDLKFLGG--ASYCKNVSCThEISSKYIPYHLLpisnYKLDTLSHYLTSriiSHINNVS 259
                     678999*******9999999********************9999..7777777777777777777766666666666666666652221122222 PP

                     CTTSSTTT.........................SSS-HHHHHHHHHHHHHTHHHHHHHHHHH CS
  DNA_pol_A_exo1 138 eqiakwqk.........................arplleeqllYAaeDadvllrlfkkLtke 174
                     +      +                          rpl+ +q++YA +D++ l+ +++ L + 
      EFC37821.1 260 QTSN---DignleeikelltysnkkelqesdwfERPLSPTQVEYATQDVITLFGVHQLLINI 318
                     2222...13335556666666666666666666**********************9988665 PP

>> Leptin  Leptin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1     2e-05     0.061      55     136 ..     241     319 ..     210     326 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2e-05
                 HHHHHH..HHHHHTS--HHHHHHHHHHHHHHHHHHHHHHHTT---------S-GGGGHHHH-BTTB-HHHHHHHHHHHHHHHHH CS
      Leptin  55 qtLavy..qqilsslpseevvqisnDlenLrallkllatsksCelekaseletleslekvleaslystevvaLeRlqksLlell 136
                 +tL  y   +i+s   +++v q snD+ nL ++ +ll+ s   el++++  e    l   ++    + +v++L  +++ L ++l
  EFC37821.1 241 DTLSHYltSRIISH--INNVSQTSNDIGNLEEIKELLTYSNKKELQESDWFE--RPLS-PTQVEYATQDVITLFGVHQLLINIL 319
                 45555522345554..589***********************9999998877..3333.3333444556777777777777766 PP

>> MscS_porin  Mechanosensitive ion channel porin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   1.3   2.7e-05      0.08      65     169 ..     337     441 ..     327     449 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.7e-05
  MscS_porin  65 kkkeeaskeilaklsleeLeqrllqtssqlqelqeqlaqlnsqlvelqtrperaqqqltearqrlqeirnrLnstaaage..alsqaqrtalqaelaal 161
                 ++ +++s+e+++ l  e+  +++l  +++ ++ +++++++++++ e+++    + +++++ + r++++  r n t++     +ls ++r+ +q+ l +l
  EFC37821.1 337 NARSADSEESPQDLEEEDSKNEYLLPLAEFSDSSKDITDIEDSIKEIEDEYKLLESKMSTLQDRIKQVMIRENITDT--RffKLSSSKRATQQVPLHLL 433
                 566788889999999999999999999*****************************************777777733..456************99999 PP

  MscS_porin 162 eaqieele 169
                    i+ ++
  EFC37821.1 434 VEHIANQR 441
                 88888776 PP

>> DUF1366  Protein of unknown function (DUF1366)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.6   0.00013      0.37      33      93 ..       3      65 ..       1      73 [. 0.87
   2 ?   -1.5   0.3      0.65   1.9e+03      78     114 ..     376     412 ..     360     415 .. 0.58
   3 ?   -2.3   0.0       1.1   3.4e+03      31      45 ..     426     440 ..     417     446 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00013
     DUF1366 33 vPvvLpaekidksntellkea..ekviYqelfPqrAenEkFneldeliekakatiektEemlk 93
                v ++   e i  + ++ l  a  e++i  +  P + ++ kF el    ++aka+i+   em++
  EFC37821.1  3 VAIFHQNEEISSPSSDNLSSAskEELINDNVSPPKSNKKKFVELISNEKQAKAKIDEWKEMIN 65
                6788889999999999999884468********************999*******99999875 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.65
     DUF1366  78 iekakatiektEemlkaatetLneiidklkeeealtd 114
                 ie + ++ie   + l+    tL++ i +++  e  td
  EFC37821.1 376 IEDSIKEIEDEYKLLESKMSTLQDRIKQVMIRENITD 412
                 3334444444444555556677777777666666555 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.1
     DUF1366  31 ayvPvvLpaekidks 45 
                  +vP+ L++e+i   
  EFC37821.1 426 QQVPLHLLVEHIANQ 440
                 689*****9998654 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.2       3.2   9.6e+03      50      72 ..      37      59 ..      18      63 .. 0.62
   2 ?   11.9   3.8   8.3e-05      0.25      26     100 ..     329     403 ..     321     437 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.2
      APG6_N 50 eeleeeleklekeeeelleeLke 72
                ++ ++++ +l + e+++ ++++e
  EFC37821.1 37 KSNKKKFVELISNEKQAKAKIDE 59
                55566666666666666666655 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 8.3e-05
      APG6_N  26 daYeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeer 100
                 ++Y ++l + ++ ++ee+ qd e+e++++e+    +e ++  + + ++e+  +e+e+e + le++ + l++  ++
  EFC37821.1 329 QSYFKYLYNARSADSEESPQDLEEEDSKNEYLLPLAEFSDSSKDITDIEDSIKEIEDEYKLLESKMSTLQDRIKQ 403
                 79***********99998899999999999555555555555555555555555555555555555555544433 PP

>> Prefoldin_2  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.2      0.22   6.5e+02      75     100 ..      40      65 ..      20      67 .. 0.72
   2 ?   -1.3   0.1       0.7   2.1e+03      27      57 ..     130     160 ..     122     165 .. 0.66
   3 ?   10.1   0.8    0.0002      0.61      69     102 ..     371     404 ..     367     407 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.22
                  HHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2  75 ekeiktlekqleklekeleelkeelq 100
                  +k+  +l +++++ +++++e+ke+++
   EFC37821.1  40 KKKFVELISNEKQAKAKIDEWKEMIN 65 
                  45555666777888888888888776 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.7
                  HHHHHHHHHHHHHHS-TT--EEEEETTEEEE CS
  Prefoldin_2  27 qlkelelvleelelldedtkvyklvGdvlvk 57 
                   lk +e v+ee  +   d+kv + +  vl+ 
   EFC37821.1 130 TLKPVENVEEENVDQFIDNKVIREIESVLIR 160
                  4555666666666666677888877777775 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.0002
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC CS
  Prefoldin_2  69 erketlekeiktlekqleklekeleelkeelqkk 102
                  +++ ++e  ik++e++++ le +++ l++ +++ 
   EFC37821.1 371 KDITDIEDSIKEIEDEYKLLESKMSTLQDRIKQV 404
                  5678899999999999999999999999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1386  (0.0773049); expected 358.6 (0.02)
Passed bias filter:                      614  (0.0342462); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.46
# Mc/sec: 3203.90
//
Query:       EFC37822.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.068   12.5   0.7      0.088   12.1   0.7    1.3  1  Mannosyl_trans3  Mannosyltransferase putative


Domain annotation for each model (and alignments):
>> Mannosyl_trans3  Mannosyltransferase putative
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.7   4.9e-06     0.088      84     138 ..     172     227 ..      70     288 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.9e-06
  Mannosyl_trans3  84 KalAllfssFeevllLDaDnvplknpdklF.eseeYkktglllwkdrdlwkrstsp 138
                       +l  +f + ++ +++D D v+ +npd lF e +++k++ l+ w +   w+++ + 
       EFC37822.1 172 LFLDKVFDTVKRTIFVDTDMVFGTNPDLLFsEFDKFKEETLFSWTREPNWESKGPN 227
                      556667888899****************994569**********665566666433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       652  (0.0363657); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2333.38
//
Query:       EFC37823.1  [L=430]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.1e-15   55.6  35.7    0.00035   20.9   4.7    6.7  7  LRR_4       Leucine Rich repeats (2 copies)
    5.1e-09   35.8  26.9    1.2e-05   25.0   4.1    6.1  8  LRR_8       Leucine rich repeat
    0.00024   20.9   0.1    0.00072   19.4   0.1    1.8  1  F-box-like  F-box-like
    0.00036   20.3   0.5     0.0013   18.5   0.0    2.3  2  F-box       F-box domain
     0.0007   19.5  16.8       0.25   11.5   0.0    6.5  7  LRR_6       Leucine Rich repeat
  ------ inclusion threshold ------
      0.087   13.4  20.1        4.8    8.1   0.5    6.8  6  LRR_1       Leucine Rich Repeat
       0.14   11.9   1.6         19    5.0   0.1    3.8  4  RecO_N_2    RecO N terminal


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.9    0.0031         8       9      33 ..     145     165 ..     141     172 .. 0.81
   2 ?   -1.2   0.1       1.3   3.2e+03      12      30 ..     201     210 ..     193     218 .. 0.55
   3 !   15.7   0.7   5.7e-06     0.015       1      31 [.     230     261 ..     230     270 .. 0.86
   4 !   15.2   1.3   8.3e-06     0.021      13      44 .]     262     294 ..     261     295 .. 0.84
   5 !   20.9   4.7   1.4e-07   0.00035       2      36 ..     297     331 ..     296     339 .. 0.85
   6 !   15.0   0.4     1e-05     0.026      11      38 ..     333     361 ..     329     369 .. 0.78
   7 !   15.5   0.1   6.9e-06     0.018       1      37 [.     347     386 ..     347     393 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0031
                 -SS---E-S-HHH-TT--EEE-.-S CS
       LRR_4   9 snNqltdiplleklpnLkeLdLsgN 33 
                  nN+l+++++   l+ L++++L +N
  EFC37823.1 145 DNNCLKELGN---LKELTKISL-RN 165
                 599****888...*********.76 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.3
                 ---E-S-HHH-TT--EEE- CS
       LRR_4  12 qltdiplleklpnLkeLdL 30 
                 +         ++ Lk L L
  EFC37823.1 201 N---------ITALKDLKL 210
                 3.........455555544 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 5.7e-06
                 SS--EEE--SS---.E-S-HHH-TT--EEE-. CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLs 31 
                 + L++LdLs + +   i+++++l+ L++L+Ls
  EFC37823.1 230 TTLTTLDLSFTPVGdAISFISNLKELRQLNLS 261
                 57************88888889********94 PP

  == domain 4  score: 15.2 bits;  conditional E-value: 8.3e-06
                 --E-S-..HHH-TT--EEE-.-S-----GGGGXX CS
       LRR_4  13 ltdipl..leklpnLkeLdLsgNnlitdldeLkn 44 
                 lt i+   l kl +L++L++s+N+ it++d L+n
  EFC37823.1 262 LTVISQipLTKLRKLEKLNISDNPCITSID-LSN 294
                 67788876779******************5.765 PP

  == domain 5  score: 20.9 bits;  conditional E-value: 1.4e-07
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnli 36 
                 +L++Ld+s+++++++ +l+ l+ L++L Ls+N  +
  EFC37823.1 297 RLRKLDISSTMISKLTGLNDLKELRKLKLSNNIEL 331
                 7****************************888333 PP

  == domain 6  score: 15.0 bits;  conditional E-value: 1e-05
                 S---E-S-.HH.H-TT--EEE-.-S----- CS
       LRR_4  11 Nqltdipl.le.klpnLkeLdLsgNnlitd 38 
                 N l  +++ ++ +lp+Lk+Ld+s N ++++
  EFC37823.1 333 NSLEFLEFmPSiNLPKLKHLDMSKN-RLES 361
                 5888888884457*********999.6655 PP

  == domain 7  score: 15.5 bits;  conditional E-value: 6.9e-06
                 SS--EEE--SS---E-S-..HH..H-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le..klpnLkeLdLsgNnlit 37 
                 p+L++Ld s N+l +  l  l   +lp L+++   gN +++
  EFC37823.1 347 PKLKHLDMSKNRLESCKLmpLTkaNLPELTTFRFGGN-KVD 386
                 79*************9999855778*********888.543 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.3      0.15   3.7e+02      34      54 ..     138     158 ..     128     168 .. 0.60
   2 ?    0.0   0.0      0.29   7.4e+02       2      24 ..     157     179 ..     156     181 .. 0.80
   3 !    7.6   1.4    0.0013       3.3       3      57 ..     205     261 ..     203     261 .. 0.77
   4 !   17.6   2.3   9.5e-07    0.0024       2      60 ..     231     285 ..     230     285 .. 0.84
   5 !   25.0   4.1   4.6e-09   1.2e-05      10      60 ..     259     307 ..     250     308 .. 0.87
   6 !   20.5   5.0   1.2e-07   0.00031       1      59 [.     274     328 ..     274     329 .. 0.93
   7 !    7.7   5.5    0.0012         3      22      61 .]     315     359 ..     307     359 .. 0.72
   8 !   10.2   0.4   0.00019      0.48      22      50 ..     344     374 ..     332     385 .. 0.67

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.15
                 SS---GGGGGGGTT--S-.EE CS
       LRR_8  34 nNllttlspgafsgLpsLrsL 54 
                 n +   ++++++  L +L++L
  EFC37823.1 138 NESKIKFDNNCLKELGNLKEL 158
                 554445555666666666665 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.29
                 T-SEEE-TTS--SEE-TTSSTT- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkgl 24 
                 +Lt+++L+n +lt  d + F ++
  EFC37823.1 157 ELTKISLRNVKLTLADYQLFGSM 179
                 69999999999998888888776 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0013
                 -SEEE-TTS--SEE-TTSSTT-TT-...-EEE--SS.---GGGGGGGTT--S-.EEE-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnL...kvLdLsnN.llttlspgafsgLpsLrsLdLs 57 
                 L+ L L++ +  +  deaFk l++L   ++LdLs     + +s   +s+L+ Lr+L+Ls
  EFC37823.1 205 LKDLKLRKLKARVNTDEAFKYLPKLttlTTLDLSFTpVGDAIS--FISNLKELRQLNLS 261
                 7777777778888889999998876111568999998888887..89999999999997 PP

  == domain 4  score: 17.6 bits;  conditional E-value: 9.5e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+LdLs++   +   ++ ++l+ L+ L+Ls   ++ +    +  L++L++L++s+N+
  EFC37823.1 231 TLTTLDLSFTPVGD-AISFISNLKELRQLNLSLTVISQIP---LTKLRKLEKLNISDNP 285
                 57778887777554.4567788*****************7...**************95 PP

  == domain 5  score: 25.0 bits;  conditional E-value: 4.6e-09
                 TS--SEE-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8  10 nNrltslddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsgNr 60 
                 n +lt++++   ++l++L+ L++s+N ++t+++   +s+L +Lr+Ld+s++ 
  EFC37823.1 259 NLSLTVISQIPLTKLRKLEKLNISDNpCITSID---LSNLVRLRKLDISSTM 307
                 334*****************************5...*************975 PP

  == domain 6  score: 20.5 bits;  conditional E-value: 1.2e-07
                 TT-SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   1 pnLtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 ++L++L++s+N  +ts+d +      +L+ Ld+s+  ++ l    + +L+ Lr+L Ls+N
  EFC37823.1 274 RKLEKLNISDNPcITSIDLSNL---VRLRKLDISSTMISKLT--GLNDLKELRKLKLSNN 328
                 68****************7655...58**************5..***************9 PP

  == domain 7  score: 7.7 bits;  conditional E-value: 0.0012
                 TT-TT--EEE--SS..---GGGGGGG...TT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnN..llttlspgaf...sgLpsLrsLdLsgNrL 61 
                 ++l+ L+ L+LsnN  l ++l+   f    +Lp+L++Ld+s NrL
  EFC37823.1 315 NDLKELRKLKLSNNieLFNSLEFLEFmpsINLPKLKHLDMSKNRL 359
                 6799999999999843333333333322258999*****999997 PP

  == domain 8  score: 10.2 bits;  conditional E-value: 0.00019
                 TT-TT--EEE--SS---G..GGGGGGTT--S CS
       LRR_8  22 kglsnLkvLdLsnNlltt..lspgafsgLps 50 
                  +l++Lk+Ld+s N+l++  l p + ++Lp 
  EFC37823.1 344 INLPKLKHLDMSKNRLESckLMPLTKANLPE 374
                 5799999999999999874455555555555 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.1   2.8e-07   0.00072      12      35 ..      49      72 ..      42      76 .. 0.90

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.8e-07
  F-box-like 12 IFsyLppsdLlrlalVCrrWrrva 35
                IF yL+ ++ + +alV+r+W+r +
  EFC37823.1 49 IFTYLHNREVIKCALVSRKWYRYV 72
                9********************987 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   5.2e-07    0.0013      10      40 ..      45      75 ..      35      81 .. 0.87
   2 ?   -2.9   0.1       2.7     7e+03      17      28 ..     289     300 ..     286     301 .. 0.78

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 5.2e-07
                HHHHHHHTS-HHHHHHHCTT-HHHHHHHTTH CS
       F-box 10 vlrhILerLplsdllalrrVSkgwrilidsd 40
                + + I+ +L  ++++ +++VS++w++++ + 
  EFC37823.1 45 ISKVIFTYLHNREVIKCALVSRKWYRYVQES 75
                55679**********************9875 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.7
                 TS-HHHHHHHCT CS
       F-box  17 rLplsdllalrr 28 
                 + +ls l++lr+
  EFC37823.1 289 SIDLSNLVRLRK 300
                 568899999996 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0         2     5e+03       2      22 ..     178     198 ..     177     200 .. 0.73
   2 !   11.5   0.0   9.8e-05      0.25       2      18 ..     229     245 ..     228     246 .. 0.90
   3 ?   -1.2   0.2       1.1   2.9e+03       5      15 ..     255     265 ..     252     266 .. 0.80
   4 !    7.5   0.1    0.0018       4.6       3      17 ..     274     289 ..     272     296 .. 0.80
   5 ?    0.3   0.0      0.37   9.5e+02       4      12 ..     297     305 ..     294     309 .. 0.84
   6 ?   -1.9   0.2       1.9   4.8e+03       5      13 ..     320     328 ..     319     328 .. 0.92
   7 !    6.7   0.1    0.0033       8.4       2      15 ..     346     359 ..     345     361 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2
       LRR_6   2 nthLteLdLsgNdIgDeGaea 22 
                 +++L+ +++++ ++   G++ 
  EFC37823.1 178 SMKLKCVEIMDSCVCELGIQN 198
                 689999999998876666655 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 9.8e-05
       LRR_6   2 nthLteLdLsgNdIgDe 18 
                  t+Lt+LdLs+  +gD+
  EFC37823.1 229 LTTLTTLDLSFTPVGDA 245
                 59*************96 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.1
       LRR_6   5 LteLdLsgNdI 15 
                 L+ L+Ls   I
  EFC37823.1 255 LRQLNLSLTVI 265
                 89999997655 PP

  == domain 4  score: 7.5 bits;  conditional E-value: 0.0018
       LRR_6   3 thLteLdLsgNd.IgD 17 
                 ++L++L++s+N  I+ 
  EFC37823.1 274 RKLEKLNISDNPcITS 289
                 79*********98886 PP

  == domain 5  score: 0.3 bits;  conditional E-value: 0.37
       LRR_6   4 hLteLdLsg 12 
                  L++Ld+s+
  EFC37823.1 297 RLRKLDISS 305
                 59*****98 PP

  == domain 6  score: -1.9 bits;  conditional E-value: 1.9
       LRR_6   5 LteLdLsgN 13 
                 L++L Ls N
  EFC37823.1 320 LRKLKLSNN 328
                 899****99 PP

  == domain 7  score: 6.7 bits;  conditional E-value: 0.0033
       LRR_6   2 nthLteLdLsgNdI 15 
                  ++L++Ld+s N +
  EFC37823.1 346 LPKLKHLDMSKNRL 359
                 589*********87 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1       2.3   5.9e+03      15      22 ..     144     151 ..     123     165 .. 0.66
   2 ?    1.8   0.1      0.23   5.8e+02       2      12 ..     232     242 ..     231     269 .. 0.77
   3 ?    8.1   0.5    0.0019       4.8       1      22 [.     275     294 ..     275     295 .. 0.80
   4 ?    1.4   0.0      0.29   7.5e+02       1      10 [.     297     306 ..     297     315 .. 0.81
   5 ?    2.8   0.8       0.1   2.6e+02       2      22 ..     320     337 ..     319     339 .. 0.76
   6 ?    7.7   0.1    0.0026       6.7       1      13 [.     348     360 ..     348     376 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 2.3
       LRR_1  15 lppnsfqn 22 
                 + +n+++ 
  EFC37823.1 144 FDNNCLKE 151
                 44555543 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.23
       LRR_1   2 LrhLdLsnnpl 12 
                 L++LdLs  p 
  EFC37823.1 232 LTTLDLSFTPV 242
                 89999998775 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.0019
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L++s+np  ++++ +++n
  EFC37823.1 275 KLEKLNISDNP--CITSIDLSN 294
                 7**********..777766666 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.29
       LRR_1   1 nLrhLdLsnn 10 
                 +Lr+Ld+s+ 
  EFC37823.1 297 RLRKLDISST 306
                 69*****985 PP

  == domain 5  score: 2.8 bits;  conditional E-value: 0.1
       LRR_1   2 LrhLdLsnnpllglppnsfqn 22 
                 Lr+L Lsnn+    + ns+++
  EFC37823.1 320 LRKLKLSNNIE---LFNSLEF 337
                 9********94...4466665 PP

  == domain 6  score: 7.7 bits;  conditional E-value: 0.0026
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L+hLd+s n+l+
  EFC37823.1 348 KLKHLDMSKNRLE 360
                 7********9983 PP

>> RecO_N_2  RecO N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.1    0.0075        19      40      60 ..     105     125 ..      97     136 .. 0.87
   2 ?   -3.3   0.0       2.9   7.5e+03      55      70 ..     224     239 ..     220     240 .. 0.79
   3 ?   -3.1   0.0       2.7   6.8e+03      55      67 ..     247     259 ..     244     262 .. 0.75
   4 ?    3.3   0.0     0.026        67      38      63 ..     327     352 ..     317     355 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0075
    RecO_N_2  40 iqlgtkidfeleengkfLprL 60 
                  +lgtki f++ en+  ++rL
  EFC37823.1 105 SHLGTKIKFKKVENDDEIKRL 125
                 589***************998 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.9
    RecO_N_2  55 kfLprLravlhlgfkw 70 
                 k+Lp+L   + l+ ++
  EFC37823.1 224 KYLPKLTTLTTLDLSF 239
                 7899999999988766 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.7
    RecO_N_2  55 kfLprLravlhlg 67 
                 +f+++L++  +l+
  EFC37823.1 247 SFISNLKELRQLN 259
                 6888898888876 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.026
    RecO_N_2  38 sliqlgtkidfeleengkfLprLrav 63 
                  +i+l+  ++f +++ +  Lp+L++ 
  EFC37823.1 327 NNIELFNSLEFLEFMPSINLPKLKHL 352
                 5799************999****985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (430 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2577.50
//
Query:       EFC37824.1  [L=453]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-73  242.0  15.3    1.1e-17   63.5   0.0    8.4  8  DUF4116        Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.048   12.9   0.3         19    4.5   0.0    3.0  3  BsuBI_PstI_RE  BsuBI/PstI restriction endonuclease domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.2   0.3   1.1e-09     1e-05       1      48 [.      26      82 ..      26      83 .. 0.84
   2 ?    2.2   0.0     0.016   1.5e+02      14      29 ..      73      88 ..      68      93 .. 0.88
   3 !   23.0   0.1   5.4e-09   4.8e-05       2      36 ..     141     176 ..     109     178 .. 0.93
   4 !   52.0   0.1   4.6e-18   4.1e-14       1      43 [.     166     208 ..     166     211 .. 0.98
   5 !   54.4   0.0   8.5e-19   7.6e-15       1      49 []     215     263 ..     215     263 .. 0.98
   6 !   63.5   0.0   1.2e-21   1.1e-17       1      49 []     265     313 ..     265     313 .. 0.99
   7 !   39.6   0.1   3.5e-14   3.2e-10       1      39 [.     315     353 ..     315     368 .. 0.91
   8 !    3.8   0.1    0.0052        46       5      20 ..     415     429 ..     411     438 .. 0.76

  Alignments for each domain:
  == domain 1  score: 25.2 bits;  conditional E-value: 1.1e-09
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt.........alsyaseeL 48
                Dr + +  +++   +++y++ e+++Dk+++lk +++  +         +++ ++++L
  EFC37824.1 26 DRKFRKLWLERREDNYQYIPIEFSHDKNFLLKFIRRENCgrdfpkaisIFEQIPPSL 82
                89999******************************6554446777777777777776 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.016
     DUF4116 14 salkylseeLknDkei 29
                s+++ ++++L++D +i
  EFC37824.1 73 SIFEQIPPSLQQDEDI 88
                57999********998 PP

  == domain 3  score: 23.0 bits;  conditional E-value: 5.4e-09
     DUF4116   2 rEivleavkkn.gsalkylseeLknDkeivlkAvkq 36 
                 r + le+v++  +++l ++s  L++D+e++++Avk+
  EFC37824.1 141 RNVLLECVRNGdSEILSHVSQQLRKDRELMMEAVKN 176
                 77889999977467*********************7 PP

  == domain 4  score: 52.0 bits;  conditional E-value: 4.6e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 DrE+++eavk+ ++++k+++++L+nD+e+v +Avk+ng al+y
  EFC37824.1 166 DRELMMEAVKNEPLSIKFADKSLQNDRELVFEAVKRNGRALEY 208
                 9****************************************99 PP

  == domain 5  score: 54.4 bits;  conditional E-value: 8.5e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv  av +++++lky++++L+nD+e+v++A+k+ g+++ yas  L+
  EFC37824.1 215 DREIVITAVNTHPEILKYVNSNLQNDFELVMEAIKSQGSCIQYASTTLK 263
                 9********************************************9886 PP

  == domain 6  score: 63.5 bits;  conditional E-value: 1.2e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr iv++ v+++g al+yl+++L+nD+eivl+Av+qng al+yas+eL+
  EFC37824.1 265 DRNIVMKSVTRYGAALQYLDDSLRNDREIVLQAVNQNGAALKYASNELK 313
                 9**********************************************97 PP

  == domain 7  score: 39.6 bits;  conditional E-value: 3.5e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 DrE+v+ a++kn++a++++s eLk+Dk ++l A+ +n +
  EFC37824.1 315 DRELVMIAIQKNPEAYEFCSTELKHDKTLALLAISKNRF 353
                 9************************************86 PP

  == domain 8  score: 3.8 bits;  conditional E-value: 0.0052
     DUF4116   5 vleavkkngsalkyls 20 
                   eavk+ng++ +y s
  EFC37824.1 415 QIEAVKSNGFYVQY-S 429
                 57899999999998.3 PP

>> BsuBI_PstI_RE  BsuBI/PstI restriction endonuclease domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0     0.085   7.6e+02      18      48 ..     104     133 ..      95     148 .. 0.70
   2 ?    4.4   0.0    0.0022        20      63     106 ..     219     265 ..     211     294 .. 0.79
   3 ?    4.5   0.0    0.0022        19      78      98 ..     408     428 ..     403     446 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.085
  BsuBI_PstI_RE  18 snllikavieefaprFlkeaevlyvgdtedk 48 
                    +  l+++++ ++a+r+ + ++++ +g  +++
     EFC37824.1 104 QDRLTEEMVVKLAKRY-QFSDIIKIGSVKKE 133
                    4567777888888887.66677777766663 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0022
  BsuBI_PstI_RE  63 eidshkklPDivlyde...eknlLvliEavtsdGpinekRkeelkel 106
                     i++ ++ P i+ y +   ++++ +++Ea++s+G+  +   ++lk+ 
     EFC37824.1 219 VITAVNTHPEILKYVNsnlQNDFELVMEAIKSQGSCIQYASTTLKKD 265
                    566677889998887777799999***********999998888875 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.0022
  BsuBI_PstI_RE  78 eeknlLvliEavtsdGpinek 98 
                    +++nlL+ iEav+s+G   + 
     EFC37824.1 408 RKNNLLLQIEAVKSNGFYVQY 428
                    6899***********976654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (453 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       700  (0.0390429); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.24s 00:00:00.83 Elapsed: 00:00:00.44
# Mc/sec: 3080.46
//
Query:       EFC37825.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.3e-06   27.7   1.2    3.8e-06   26.9   0.2    1.8  2  MMR_HSR1      50S ribosome-binding GTPase
    9.7e-06   25.1   0.5    1.9e-05   24.1   0.5    1.5  1  AIG1          AIG1 family
    0.00012   22.3   0.1    0.00051   20.2   0.0    2.1  2  Roc           Ras of Complex, Roc, domain of DAPkinase
    0.00041   20.1   0.1     0.0041   16.9   0.0    2.2  2  AAA_24        AAA domain
     0.0015   18.1   0.2     0.0047   16.4   0.0    1.8  2  Arf           ADP-ribosylation factor family
     0.0023   18.2   0.0     0.0057   16.9   0.0    1.7  1  AAA_22        AAA domain
     0.0023   18.4   1.5     0.0034   17.9   0.9    1.9  1  ABC_tran      ABC transporter
     0.0038   17.3   0.0     0.0078   16.3   0.0    1.7  1  Dynamin_N     Dynamin family
     0.0049   16.3   0.0      0.016   14.6   0.0    1.9  1  SRPRB         Signal recognition particle receptor beta subun
     0.0052   16.5   0.2      0.052   13.3   0.0    2.4  2  AAA_29        P-loop containing region of AAA domain
     0.0065   16.4   0.4      0.062   13.2   0.0    2.4  3  RsgA_GTPase   RsgA GTPase
     0.0074   16.3   0.7       0.26   11.3   0.2    2.3  2  DUF758        Domain of unknown function (DUF758)
     0.0084   15.3   1.7      0.012   14.8   0.4    2.1  2  G-alpha       G-protein alpha subunit
     0.0085   16.4   0.1      0.015   15.6   0.1    1.4  1  AAA_28        AAA domain
     0.0095   16.5   0.0       0.02   15.4   0.0    1.7  1  AAA_18        AAA domain
  ------ inclusion threshold ------
      0.016   14.8   0.0      0.041   13.4   0.0    1.7  1  AAA_7         P-loop containing dynein motor region
      0.018   14.8   0.5        4.3    7.0   0.1    2.3  2  ATP_bind_1    Conserved hypothetical ATP binding protein
      0.023   14.3   3.7       0.18   11.4   0.8    2.9  2  Ras           Ras family
      0.024   14.2   0.3      0.081   12.5   0.0    1.9  2  cobW          CobW/HypB/UreG, nucleotide-binding domain
      0.026   14.9   0.0      0.062   13.7   0.0    1.6  1  AAA_16        AAA ATPase domain
       0.06   13.4   0.0       0.14   12.2   0.0    1.8  1  AAA_14        AAA domain
      0.088   12.6   0.0       0.34   10.6   0.0    2.0  1  PduV-EutP     Ethanolamine utilisation - propanediol utilisat
      0.095   12.0   0.3       0.22   10.9   0.1    1.7  2  FtsK_SpoIIIE  FtsK/SpoIIIE family
       0.11   12.6   0.1       0.74   10.0   0.0    2.1  2  AAA_33        AAA domain
       0.17   10.9   0.2       0.27   10.3   0.2    1.3  1  T2SSE         Type II/IV secretion system protein
       0.75   10.3   6.2        3.2    8.2   6.2    2.2  1  AAA_23        AAA domain


Domain annotation for each model (and alignments):
>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   0.2   5.6e-09   3.8e-06       1     113 [.       6     135 ..       6     136 .. 0.60
   2 ?   -1.4   0.0       3.6   2.5e+03      53      57 ..     249     253 ..     202     295 .. 0.52

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 5.6e-09
                 EEEEEESTTSSHHHHHHHHHTSTEEESSST.TSSSSEEEEE.EE.....ETTEEEEEEECGGCSS......HHHHHH...HHHHHHHH.HHC.TSEEEE CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkp.gtTrdinegr.vk.....lkgkeielvDtpGlie......gaseek...glgkafla.lee.adlill 81 
                 +v+i+G + +GK+t++n ltge+  + d + g+T +++ +  ++     ++gk +++ Dt+Gl e      ++          k+fl+      +l+++
  EFC37825.1   6 RVLIYGCSGSGKTTILNNLTGENFNTDDSAvGVTFQMTIIPpINkqgteINGKIYRFDDTVGLNEcesgtvDN---FtafVKLKDFLKdSLTgFNLFIY 101
                 699*******************998877666999998777523344444667779*******64332221111...12222333333312234688888 PP

                 EEETT...TTCSHHHHHHHHHHHHHTTSEEEEEEE CS
    MMR_HSR1  82 vvdas...eeklkpldeeleelleeakkplilvln 113
                 v++     ++++k++ + + ++l ++k p+++v++
  EFC37825.1 102 VFEKGritSSDVKNV-QLFSQILGQNKVPTLMVVS 135
                 887333332223333.3445555557777777766 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 3.6
                 CGGCS CS
    MMR_HSR1  53 tpGli 57 
                 ++G++
  EFC37825.1 249 IAGIF 253
                 34433 PP

>> AIG1  AIG1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.5   2.7e-08   1.9e-05       2     140 ..       6     152 ..       5     180 .. 0.79

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 2.7e-08
                 EEEEESSTTSSHHHHHHHHHTS--SS--TTTS---SS-E......EEEEEETTEEEEEEE--SCCCTTC...CHHCHHHHHHHHHHHCTT-ESEEEEEE CS
        AIG1   2 tivlvGktgnGkSaTgNsilgkkaFesklsaqsvtkkcq......kksrtwdgkkinViDTPglfdlsv...sadkiskeivrclllseegihalllvl 91 
                 ++++ G +g+Gk +  N++ g++ F++  sa +vt +++      k+ ++ +gk+    DT gl + ++   ++ ++  + ++ l+ s +g + +++v+
  EFC37825.1   6 RVLIYGCSGSGKTTILNNLTGEN-FNTDDSAVGVTFQMTiippinKQGTEINGKIYRFDDTVGLNECESgtvDNFTAFVKLKDFLKDSLTGFNLFIYVF 103
                 8999**************99976.89998999999887622222134446666666788*****6655422245555667888899999********** PP

                 ETTB-SHHHHHHHHHHHHHHCGGGGGGEEEEEEEGGGGTTCCHHHHHHH CS
        AIG1  92 slgrfteedekalktlkelFGekilkylivvftrkddleddsledylsk 140
                 + gr+t+ d k ++   ++ G++ +  l vv     d + +sl+d  ++
  EFC37825.1 104 EKGRITSSDVKNVQLFSQILGQNKVPTLMVVSKADTDNGLKSLDDLTNN 152
                 ***********************99999999888888888888887664 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   7.4e-07   0.00051       1      70 [.       6      72 ..       6      85 .. 0.76
   2 ?   -1.9   0.0       5.5   3.8e+03      82     119 ..      98     138 ..      90     139 .. 0.50

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 7.4e-07
                EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTT CS
         Roc  1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfr 70
                +v++ G sg+GKt++l++++ ++f+++ +s +gv+f  + +  i++  +  +++   +++ Dt G ++++
  EFC37825.1  6 RVLIYGCSGSGKTTILNNLTGENFNTD-DSAVGVTFQMTIIPPINKQGT--EINGKIYRFDDTVGLNECE 72
                58899*******************877.6789****9988877766433..3444456666777776665 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 5.5
                 EEEEEEE..GHHHHCHHHHHHHHHHHCS..SS-EEEEEE-TT CS
         Roc  82 lailvyd..srssenlkeWlkelkkvag..kspvilvgnkiD 119
                 l+i+v++  + +s+++k  ++ +++  g  k p ++v++k+D
  EFC37825.1  98 LFIYVFEkgRITSSDVK-NVQLFSQILGqnKVPTLMVVSKAD 138
                 55666653211233332.233333333311447788888887 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   5.9e-06    0.0041       2      25 ..       4      28 ..       3      96 .. 0.86
   2 ?    1.0   0.0      0.42   2.9e+02      29      44 ..     133     152 ..     119     191 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 5.9e-06
      AAA_24  2 klkiliyGpsgiGKTtlakel.gpk 25
                ++++liyG sg+GKTt++++l g++
  EFC37825.1  4 ERRVLIYGCSGSGKTTILNNLtGEN 28
                679****************995444 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.42
      AAA_24  29 i....dtekGlksldadkfp 44 
                 +    dt++Glksld+   +
  EFC37825.1 133 VvskaDTDNGLKSLDDLTNN 152
                 345559********998865 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   6.9e-06    0.0047      13      50 ..       3      40 ..       1      56 [. 0.87
   2 ?   -1.4   0.0         2   1.4e+03     112     133 ..     124     145 ..      94     164 .. 0.64

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 6.9e-06
                TEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEE CS
         Arf 13 kelrilllGLDnaGKtTilkklkleelvttvPTigfnv 50
                 e r+l+ G  ++GKtTil++l+ e+++t    +g + 
  EFC37825.1  3 TERRVLIYGCSGSGKTTILNNLTGENFNTDDSAVGVTF 40
                689***********************999877777665 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2
                 CCTTSEEEEEEE-TTSTTSS-H CS
         Arf 112 elkevallvlaNKqDlpealse 133
                   ++v+ l++  K D+ + l++
  EFC37825.1 124 GQNKVPTLMVVSKADTDNGLKS 145
                 3457777888888887776554 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   8.2e-06    0.0057       4      29 ..       3      28 ..       1      57 [. 0.85

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 8.2e-06
      AAA_22  4 tagilvvtGesGtGKTtllrrlleql 29
                t++ ++++G+sG+GKTt l++l+ ++
  EFC37825.1  3 TERRVLIYGCSGSGKTTILNNLTGEN 28
                566689***************98765 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.9   4.9e-06    0.0034       9      41 ..       2      34 ..       1     165 [. 0.83

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 4.9e-06
                ETTSEEEEEESTTSSHHHHHHHHTTSS--SEEE CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  9 kegekvaivGenGaGKStLlkllagllkpteGe 41
                k  ++v i G +G+GK+t+l+ l+g+  +t ++
  EFC37825.1  2 KTERRVLIYGCSGSGKTTILNNLTGENFNTDDS 34
                567899*******************98776555 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   1.1e-05    0.0078       2      50 ..       8      57 ..       7     137 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.1e-05
                EEEEBTTTTHHHHHHHHHTS--S-.--SSS---S-EEEEECCT---CCS. CS
   Dynamin_N  2 avvGsqSsGKSSvlnaLlgedilp.rgpnptTrrplelqlgeeeeasera 50
                ++ G   sGK+++ln+L+ge+++   ++  +T  ++++   +++  + + 
  EFC37825.1  8 LIYGCSGSGKTTILNNLTGENFNTdDSAVGVTFQMTIIPPINKQGTEING 57
                6778889****************955666999999999998777765333 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   2.4e-05     0.016       2      29 ..       3      30 ..       2      56 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.4e-05
                ---EEEEE-STTSSHHHHHHHHHHSS-- CS
       SRPRB  2 skpavllvGlsdsGKTslftrLttdsvk 29
                ++++vl+ G s sGKT++++ Lt ++++
  EFC37825.1  3 TERRVLIYGCSGSGKTTILNNLTGENFN 30
                5789******************988554 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   7.5e-05     0.052      24      39 ..       6      21 ..       1      30 [. 0.83
   2 ?    0.2   0.0      0.95   6.5e+02       5      17 ..     229     242 ..     227     256 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 7.5e-05
      AAA_29 24 atlltGpsGsGKSTll 39
                 +l+ G sGsGK+T+l
  EFC37825.1  6 RVLIYGCSGSGKTTIL 21
                58*************9 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.95
      AAA_29   5 qlvNWgtfdg.hti 17 
                 +++NW +++  +t+
  EFC37825.1 229 RVLNWFYINTkKTF 242
                 689****9995544 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.0   8.9e-05     0.062     100     123 ..       5      28 ..       1      42 [. 0.83
   2 ?    0.2   0.0       0.9   6.2e+02      42      67 ..     123     148 ..     108     171 .. 0.75
   3 ?   -2.3   0.0       5.4   3.7e+03      90     110 ..     262     282 ..     216     286 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 8.9e-05
                  SEEEEECSTTSSHHHHHHHHCTT- CS
  RsgA_GTPase 100 ktsvlvGqSGvGKStLinallpel 123
                  + +++ G SG GK+t++n+l++e+
   EFC37825.1   5 RRVLIYGCSGSGKTTILNNLTGEN 28 
                  667899**************9983 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.9
                  HHHTT-EEEEEEE-GGG--HHHHHHH CS
  RsgA_GTPase  42 aeekgiepvivlnKiDlleeeeelee 67 
                  + +++++ ++v++K+D  +  ++l++
   EFC37825.1 123 LGQNKVPTLMVVSKADTDNGLKSLDD 148
                  56788999999999999887774444 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 5.4
                  HHHHHHHCTTSEEEEECSTTS CS
  RsgA_GTPase  90 leelkellkdktsvlvGqSGv 110
                   +el+e+l++ t +l+ + Gv
   EFC37825.1 262 RDELEEKLENVTQALMINFGV 282
                  456666666666666655555 PP

>> DUF758  Domain of unknown function (DUF758)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.2   0.00038      0.26      72     137 ..     151     215 ..     148     228 .. 0.91
   2 ?    3.1   0.0      0.12        82      28      61 ..     261     295 ..     248     296 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00038
      DUF758  72 rnkqlsaeelallekfrkklrtlamtlisfyevdftfdkavLadlLkecrellkqlverhLtdksl 137
                 +n+ ++++e +l++ f ++++  a++++ f + +ft +++ +  l+++ r+ll  l+++h +d s+
  EFC37825.1 151 NNTWIKQNESQLASAFGEQTFC-AKQTVAFPQPSFTSNNESINLLCNTSRKLLFDLIDQHASDESI 215
                 6778999999999999999886.678899*********************************9997 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.12
      DUF758  28 iddtsselldelykllkeytg.nkkeaekvvKnii 61 
                 + d+  e l+++ + l  + g +k++a++v K+i+
  EFC37825.1 261 VRDELEEKLENVTQALMINFGvSKEKAQEVAKDIL 295
                 5688888999999998888888***********96 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.4   1.8e-05     0.012      23      52 ..       4      30 ..       1     220 [. 0.90
   2 ?   -0.8   0.0      0.98   6.7e+02     275     310 ..     258     292 ..     252     295 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.8e-05
                EEEEEEEESTTSSHHHHHHHHHHHCS---- CS
     G-alpha 23 evkllllGqseSGKsTilkqlkllykkgfs 52
                e ++l+ G+s+SGK+Til++l    +++f+
  EFC37825.1  4 ERRVLIYGCSGSGKTTILNNLT---GENFN 30
                5599***************987...44444 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.98
                 EEE-HHHHHHHCCCS-GGGCCTT--H.CCHHHHHHH CS
     G-alpha 275 flnKlDileeKlkkgklskyfpsyegrkndlesvlk 310
                 ++n  D leeKl+++  + ++ +++ +k+++++v+k
  EFC37825.1 258 VFNVRDELEEKLENVTQALMI-NFGVSKEKAQEVAK 292
                 5888999*****999776654.77777777776665 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.1   2.1e-05     0.015       1      23 [.       6      28 ..       6      39 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.1e-05
      AAA_28  1 kivitGgestGKTtlleaLaarg 23
                ++ i G++++GKTt+l++L+ ++
  EFC37825.1  6 RVLIYGCSGSGKTTILNNLTGEN 28
                699****************9654 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0     3e-05      0.02       1      22 [.       7      28 ..       7      82 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3e-05
      AAA_18  1 IlltGtpGvGKttlakeLskrl 22
                +l+ G++G+GKtt+ ++L  ++
  EFC37825.1  7 VLIYGCSGSGKTTILNNLTGEN 28
                79****************6653 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   5.9e-05     0.041      31      60 ..       2      32 ..       1      47 [. 0.74

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 5.9e-05
       AAA_7 31 knkkpvllvGptGtGKtviikd.llkkldke 60
                k ++ vl++G +G+GKt+i+++ + ++++++
  EFC37825.1  2 KTERRVLIYGCSGSGKTTILNNlTGENFNTD 32
                78899*****************555555533 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0     0.013       9.1       1      17 [.       9      25 ..       9      36 .. 0.87
   2 ?    7.0   0.1    0.0062       4.3     121     208 ..      94     177 ..      75     211 .. 0.59

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.013
  ATP_bind_1  1 vvGpaGsGKttfvgals 17
                + G+ GsGKtt+ ++l+
  EFC37825.1  9 IYGCSGSGKTTILNNLT 25
                67*********999875 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0062
  ATP_bind_1 121 efalvvvyLvDsqrltd....ptkfisgllsalsamlrlelPhvvvlnkfDllkeklekeleffedvealslllekeeekykklaeaiaell 208
                 ++    +y+++  r+t+     ++++s+      ++ + ++P+++v++k+D  + +  k l+ +++   +++ + +  +++ +++ + ++++
  EFC37825.1  94 TGFNLFIYVFEKGRITSsdvkNVQLFSQ------ILGQNKVPTLMVVSKADT-D-NGLKSLDDLTNNTWIKQNESQLASAFGEQTFCAKQTV 177
                 4555667888888888754444555555......999**************9.3.3444444444444444444444455555555555544 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.8   0.00026      0.18       2      42 ..       7      46 ..       6     202 .. 0.77
   2 ?    1.7   0.1      0.25   1.7e+02      61     103 ..     216     259 ..     160     295 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00026
                EEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEE CS
         Ras  2 lvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeie 42
                +++ G s+ GKt++l++ + ++F+++ +s +gv f+++ i 
  EFC37825.1  7 VLIYGCSGSGKTTILNNLTGENFNTD-DSAVGVTFQMTIIP 46
                7889*******************998.78899998877653 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.25
                 GHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHST.T CS
         Ras  61 fkslrelyyrdaegillvyditsresfenvkkwveeikrvae.e 103
                 f   +e++++  + +l  + i+ +++f ++ + +  i  +++  
  EFC37825.1 216 FIVTKENFMTVLTRVLNWFYINTKKTFASIGNAIAGIFGHKDvF 259
                 44555667777777888899999999999999888888887741 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   0.00012     0.081       4      30 ..       8      35 ..       6      60 .. 0.83
   2 ?   -1.5   0.0       2.3   1.6e+03     140     159 ..     127     146 ..      80     161 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00012
                EEEESTTCCHHHHHHHHH.CT--SS-EE CS
        cobW  4 vltGflGsGKTtLlnhll.enraglkla 30
                ++ G  GsGKTt+ln+l+ en +  + a
  EFC37825.1  8 LIYGCSGSGKTTILNNLTgENFNTDDSA 35
                68899************98544444444 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 2.3
                 HTSSEEEEE-HHHHCHC..H CS
        cobW 140 aaadllvlnKtDlldeeall 159
                 ++  l+v++K+D+ +  ++l
  EFC37825.1 127 KVPTLMVVSKADTDNGLKSL 146
                 55678999999986655544 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0     9e-05     0.062      24      45 ..       4      25 ..       1      46 [. 0.82

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 9e-05
      AAA_16 24 pelvllsGesGvGKsslvrell 45
                ++ vl++G sG+GK+++++ l 
  EFC37825.1  4 ERRVLIYGCSGSGKTTILNNLT 25
                4789**************8875 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0    0.0002      0.14       4      39 ..       6      41 ..       3     102 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.0002
      AAA_14  4 ilvitGaRrvGKTtllkqlikellvkkesilyinld 39
                 ++i G+  +GKTt+l++l  e++ +++s + ++++
  EFC37825.1  6 RVLIYGCSGSGKTTILNNLTGENFNTDDSAVGVTFQ 41
                589*****************9999777777777665 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0    0.0005      0.34       2      27 ..       5      30 ..       4      46 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.0005
   PduV-EutP  2 kkilliGkvgsGKttLtqalkgeelk 27
                +++l+ G +gsGKtt+ ++l+ge+++
  EFC37825.1  5 RRVLIYGCSGSGKTTILNNLTGENFN 30
                799******************99875 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   0.00031      0.22      41      59 ..       6      24 ..       1      26 [. 0.89
   2 ?   -2.4   0.0       3.5   2.4e+03     101     130 ..     254     284 ..     243     295 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00031
                  SEEEE--TTSSHHHHHHHH CS
  FtsK_SpoIIIE 41 hllvaGatgsGKStalntL 59
                   +l+ G +gsGK+t ln+L
    EFC37825.1  6 RVLIYGCSGSGKTTILNNL 24
                  58***************98 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3.5
                   SHHHHHHHHHHHHHHHHHHH.HHHHHTT-SS CS
  FtsK_SpoIIIE 101 dperalraleeLvkemeery.alfreagvrs 130
                   + +++ ++ +eL++++e++  al+ ++gv +
    EFC37825.1 254 GHKDVFNVRDELEEKLENVTqALMINFGVSK 284
                   4566666667777777776656666666654 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0    0.0011      0.74       2      22 ..       7      27 ..       7      39 .. 0.86
   2 ?    0.1   0.0       1.2   8.3e+02      88     108 ..     119     139 ..     107     230 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.0011
      AAA_33  2 vllvGlpGsGKstlaerllkk 22
                vl+ G +GsGK+t + +l  +
  EFC37825.1  7 VLIYGCSGSGKTTILNNLTGE 27
                6789***********999766 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 1.2
      AAA_33  88 flklarrlgvpvrivvvetde 108
                 f +++ + +vp ++vv ++d 
  EFC37825.1 119 FSQILGQNKVPTLMVVSKADT 139
                 555555555555555555543 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.2   0.00039      0.27     130     152 ..       5      27 ..       1      39 [. 0.77

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00039
       T2SSE 130 glilvsGgTgsGKttllyallke 152
                   +l+ G  gsGKtt+l+ l  e
  EFC37825.1   5 RRVLIYGCSGSGKTTILNNLTGE 27 
                 6789*************988765 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   6.2    0.0047       3.2      23      39 ..       8      24 ..       6     294 .. 0.92

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0047
      AAA_23 23 lItGpNGaGKTTildAi 39
                lI+G  G+GKTTil+ +
  EFC37825.1  8 LIYGCSGSGKTTILNNL 24
                9*************966 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                       110  (0.00613531); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              26  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 1742.49
//
Query:       EFC37826.1  [L=453]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-17   63.9   1.7    4.6e-17   62.5   1.7    1.7  1  RNase_H          RNase H
     0.0012   18.6   0.0     0.0025   17.6   0.0    1.6  1  RVT_3            Reverse transcriptase-like
  ------ inclusion threshold ------
      0.012   15.6   0.1      0.027   14.5   0.1    1.5  1  Adeno_GP19K      Adenovirus GP19K
       0.05   14.3   4.1      0.074   13.8   1.6    2.7  2  zf-RVT           zinc-binding in reverse transcriptase
       0.11   12.4   0.0       0.28   11.1   0.0    1.7  1  dCMP_cyt_deam_1  Cytidine and deoxycytidylate deaminase zinc-


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.5   1.7   1.3e-20   4.6e-17       3     142 ..     143     269 ..     141     270 .. 0.77

  Alignments for each domain:
  == domain 1  score: 62.5 bits;  conditional E-value: 1.3e-20
                 SEEEEEEEEEECTTTCEEEEE.EECTT....EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSBH CS
     RNase_H   3 avvvYtDGsclgnpgeggaga.vlykeg..arnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkpv 98 
                 + +++tDGs +    e ++g+ v+ +++  ++ ++ +l+   +nn aELsA+++aL+    +++ ++ tDS+ +vk i++        ++k + +q  +
  EFC37826.1 143 EFTIWTDGSKS----ENKVGFsVIIQNNefTKGYKYKLHSYHSNNMAELSAITTALHIIPPNSNAKVLTDSEIAVKIINN-------TNYKGQFKQ--I 228
                 5799*****44....55666654443431244555555699****************966678888**********6665.......344455555..7 PP

                 TTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHHH CS
     RNase_H  99 knkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkeaa 142
                 k  ++ +l+   +kk + +++w k+H+G++ gN+ aD+ Ak+a+
  EFC37826.1 229 KD-EITNLI--STKKLQASIEWTKAHTGITDGNNYADKKAKQAS 269
                 77.888888..68999**************************96 PP

>> RVT_3  Reverse transcriptase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0     7e-07    0.0025       3     123 ..     149     267 ..     147     268 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 7e-07
       RVT_3   3 dgafkkksgaggagvvirdsnGevllagaeklqgkasveeAElqALlrGLqlalklgirrlvvegDsktvvqllngrekvksselanlldeirkllk.s 100
                 dg  +k++++ g+ v+i   n e++ +++ kl++  s+ +AEl+A+  +L ++  +   +  v +Ds+  v+ +n+ +   + + +++ dei +l++ +
  EFC37826.1 149 DG--SKSENKVGFSVIIQ--NNEFTKGYKYKLHSYHSNNMAELSAITTALHIIPPNSNAK--VLTDSEIAVKIINNTNY--KGQFKQIKDEITNLIStK 239
                 66..66667767777775..557999****************************997665..669*************5..999999999999999987 PP

       RVT_3 101 fesvsvehip.....ReqNrvAdalAkr 123
                   ++s+e+ +      ++N +Ad+ Ak+
  EFC37826.1 240 KLQASIEWTKahtgiTDGNNYADKKAKQ 267
                 7788888876222224567777776665 PP

>> Adeno_GP19K  Adenovirus GP19K
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.1   7.6e-06     0.027      14      74 ..     120     183 ..     113     210 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 7.6e-06
  Adeno_GP19K  14 tlikcttehekliirhkdkigkyavyaiwqpgdtndynv..tvf.qged.rkvflykfpfyemcd 74 
                  t  kc t+h+ l+ + kd+   y+ ++iw  g   + +v  +v+ q ++ +k + yk+  y   +
   EFC37826.1 120 TTTKCNTNHQ-LLEKEKDEQYSYSEFTIWTDGSKSENKVgfSVIiQNNEfTKGYKYKLHSYHSNN 183
                  668*****96.7889*****************887665522333133332678888887775444 PP

>> zf-RVT  zinc-binding in reverse transcriptase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.6   9.4e+03      38      52 ..     118     132 ..      97     139 .. 0.67
   2 ?   13.8   1.6   2.1e-05     0.074      27      81 ..     327     374 ..     278     377 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.6
      zf-RVT  38 lllknrlptadnllk 52 
                 +l + +++t+++ll+
  EFC37826.1 118 KLTTTKCNTNHQLLE 132
                 445566677776665 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 2.1e-05
      zf-RVT  27 kappkvkfflWlllknrlptadnllkrgiesssrCqlCgqeeEtieHlfleCpfa 81 
                 +  p +k+ +W+l      ++  l++  ++ +++C+ C+++  ++eHlf+eCp  
  EFC37826.1 327 HTTPTHKYSIWRL-----MINGHLRSLIVD-NPQCPTCNKN-LDTEHLFIECPEM 374
                 5556666666644.....455667777677.999******6.6789******965 PP

>> dCMP_cyt_deam_1  Cytidine and deoxycytidylate deaminase zinc-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   7.8e-05      0.28      20      67 ..     151     200 ..     133     216 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 7.8e-05
                      TTTSCSEEEEEEETTEEEEEEESBHHCCTGTTB-HHHHHHHHHHHH.T.S CS
  dCMP_cyt_deam_1  20 kcsnfkVGavivkngeiistgyngepaggsktiHAEvnAilkaakn.g.g 67 
                       +s+ kVG  ++ +++ + +gy  + +++   + AE++Ai++a+ + + +
       EFC37826.1 151 SKSENKVGFSVIIQNNEFTKGYKYKLHSYHSNNMAELSAITTALHIiPpN 200
                      6788999977777669***************************9885544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (453 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       972  (0.0542138); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.47
# Mc/sec: 2922.96
//
Query:       EFC37827.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.8e-08   33.6   0.0    4.2e-08   33.1   0.0    1.4  1  DSPc             Dual specificity phosphatase, catalytic doma
      4e-06   26.6   0.0    5.3e-06   26.2   0.0    1.1  1  Y_phosphatase    Protein-tyrosine phosphatase
  ------ inclusion threshold ------
      0.013   15.6   0.0      0.019   15.1   0.0    1.2  1  PTPlike_phytase  Inositol hexakisphosphate


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.1   0.0     7e-12   4.2e-08      15     121 ..      38     151 ..      26     164 .. 0.63

  Alignments for each domain:
  == domain 1  score: 33.1 bits;  conditional E-value: 7e-12
                 HHHTCSEEEEESSSSSECECCTTTTSEEEEECCES...STTSCCGGGHHHHHHHHHHH...HHTT-EEEEEESSSSSHHHHHHHHHHHHHHTSCHHHHH CS
        DSPc  15 sklgitlvinvtkevpnanalkkseieklripved...ehetkiskyleeavefidka...kqkgkkvlVHCqaGisRSatliiaYlmktknlslneay 107
                 +++++t+ + v + +  +   +  +i++++   +d     +  i+++l+ + ++        ++   ++VHC aG+ R + l++  l+k+ n++  ea+
  EFC37827.1  38 KQNNVTHCVRVCQATYDKEVVERAGIKFFDWAFDDgssPPKHVIQDWLDLVDKVFPPKegdSDDLPCIAVHCVAGLGRAPILVALALIKRCNMTGLEAV 136
                 55555555555533333333344444444444444443334444444444444444333323333459******************************* PP

                 HHHHHHS.TT-SSTH CS
        DSPc 108 eflkerr.paispna 121
                 +fl+++r +ai++n 
  EFC37827.1 137 QFLRKKRrGAINKNQ 151
                 ***776659999983 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.0   8.8e-10   5.3e-06     105     228 ..      34     154 ..      22     159 .. 0.66

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 8.8e-10
                    EE.EEEEEESSEEEEEEEEEETTTTEEEEEEEEEEESSS-.SSS.SG..SCCHHHHHHHHHHHHHH...STTSS-EEEECSSSSHHHHHHHHHHHH CS
  Y_phosphatase 105 lkekekedekeyvlrelevkkkkeeseerevkqlqytnWp.dhg.vp..esaksllklirkveksk...eaksgpvvVhCsaGvgRtgtfvaldil 193
                    +k + k+++   v++ ++v + + ++e  e   +++ +W  d g  p  +  ++ l+l++kv   k   +++   + VhC aG gR+ ++val ++
     EFC37827.1  34 VK-EFKQNN---VTHCVRVCQATYDKEVVERAGIKFFDWAfDDGsSPpkHVIQDWLDLVDKVFPPKegdSDDLPCIAVHCVAGLGRAPILVALALI 125
                    33.333333...44444444444444445667788888987444344334578888999999888877555556688**********999988755 PP

                    HHHHHHHSEEEHHHHHHHHHTTSTTSS-SHHHHHH CS
  Y_phosphatase 194 lqqleaeeevdvlqivkelrkqRpgmvqtleqyif 228
                     ++ +    +  l++v+ lrk+R+g++++ +q+ f
     EFC37827.1 126 KRC-N----MTGLEAVQFLRKKRRGAINK-NQLDF 154
                    443.3....35799************986.55555 PP

>> PTPlike_phytase  Inositol hexakisphosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.0   3.1e-06     0.019      76     152 ..      39     123 ..      14     126 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 3.1e-06
                      ............EE-HHHHHHHTT-EEEEEEE-TTS---HHHHHHHHHHHHTS.-T.......T-EEEEE-SSSSHHHHHHHHHH CS
  PTPlike_phytase  76 lqevweevetpeevyerelaeelslrYaRipitdekapeeedfdalvsilkea.pe.......ktalvfnCqmGrgRTTtamvia 152
                       ++v++ v++ +  y++e+ e+ +++++  ++ d  +p +  +++ ++++ ++ p         +++ ++C +G gR  + +++a
       EFC37827.1  39 QNNVTHCVRVCQATYDKEVVERAGIKFFDWAFDDGSSPPKHVIQDWLDLVDKVfPPkegdsddLPCIAVHCVAGLGRAPILVALA 123
                      24455556678899***************************************9778*****99*************97766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       695  (0.038764); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.46u 0.31s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1105.31
//
Query:       EFC37828.1  [L=357]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (357 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1019  (0.0568353); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 2228.37
//
Query:       EFC37829.1  [L=377]
Description: hypothetical protein NAEGRDRAFT_55489 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   7.5e-148  492.5   0.0     3e-147  490.5   0.0    1.7  1  Actin            Actin
  ------ inclusion threshold ------
       0.14   10.6   0.0       0.33    9.4   0.0    1.6  2  Methyltransf_29  Putative S-adenosyl-L-methionine-dependent m


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  490.5   0.0  3.3e-151    3e-147       2     407 .]       5     377 .]       4     377 .] 0.98

  Alignments for each domain:
  == domain 1  score: 490.5 bits;  conditional E-value: 3.3e-151
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 ++v+a+V+DnGs++++aG+ag+daP+av+ps++g+p++++ +      + yvgdea++kr+ l++++p+e+G+v++wd++e++w+h++++elkv peeh
  EFC37829.1   5 EDVQALVVDNGSGMCKAGFAGDDAPRAVFPSIIGRPKQKSIMVgmgnkDAYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELKVAPEEH 103
                 689************************************998899**9*************************************************** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvev 194
                 p+llte+plnp+++rek+++i+fE+f vpa+y++ +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G++Lte+l+++l ++    
  EFC37829.1 104 PVLLTEAPLNPKANREKMTQIMFETFTVPAMYVSIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYSLPHAILRLDLAGRDLTEYLMKILMER---- 198
                 **********************************************************************************************8.... PP

       Actin 195 tprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligs 291
                                           ++s++t++e+e++++iKe++c+v+ d+e   + +++sss eksYeLPDg++i++g+eRf++pE+LF+p+ ig+
  EFC37829.1 199 --------------------------GYSFNTTAEREIVRDIKEKLCYVALDFESemKVAAESSSVEKSYELPDGNVITVGNERFRCPEVLFQPNFIGM 271
                 ..........................9**************************996666677799********************************** PP

       Actin 292 esaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvs 390
                 e a         g++e ++++i +cd+d+r++L+ n+v++GG+++++g+ +R+ kel+++a++++kvk++ap+ erkys+WiGGSiLAsl tfqq+w+s
  EFC37829.1 272 EAA---------GVHETAFNSIGKCDIDIRKDLYGNVVLSGGTTMFEGIADRMTKELTAMAPASMKVKVVAPP-ERKYSVWIGGSILASLATFQQMWIS 360
                 *99.........*************************************************************.************************* PP

       Actin 391 kqEYeEqGssvverkck 407
                 k+EY++ G+ +++rkc+
  EFC37829.1 361 KEEYDDAGPGFIHRKCF 377
                 ****************6 PP

>> Methyltransf_29  Putative S-adenosyl-L-methionine-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   3.7e-05      0.33     103     163 ..     136     200 ..     122     220 .. 0.88
   2 ?   -2.6   0.0      0.16   1.5e+03      87     112 ..     301     326 ..     297     332 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 3.7e-05
  Methyltransf_29 103 dklaelipliaaggkvrtvlDvGCgvas....fgayllsrdvltlslapkDeheaqvqfaLeRgv 163
                       +++ +++l a+g ++ +vlD G gv+     + +y l + +l l la +D  e  +++ +eRg 
       EFC37829.1 136 VSIQAVLSLYASGRTTGIVLDSGDGVSHtvpiYEGYSLPHAILRLDLAGRDLTEYLMKILMERGY 200
                      46899999999*************9985444489*****************************95 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.16
  Methyltransf_29  87 fPgggtqfkkgadkYidklaelipli 112
                        gg t+f+  ad+  ++l+ + p+ 
       EFC37829.1 301 LSGGTTMFEGIADRMTKELTAMAPAS 326
                      67999*********999999999874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       345  (0.0192426); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2403.87
//
Query:       EFC37830.1  [L=2470]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    8.6e-17   61.1   6.0    8.6e-17   61.1   6.0    4.1  4  REJ         REJ domain
    2.6e-16   59.7  74.2    0.00023   21.5  10.0    5.9  5  EGF_2       EGF-like domain
  ------ inclusion threshold ------
      0.094   12.5   0.1       0.25   11.1   0.1    1.7  1  TMEM132D_C  Mature oligodendrocyte transmembrane protein, TME


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -12.6  13.4         3   1.8e+04     135     274 ..    1075    1219 ..    1043    1233 .. 0.45
   2 ?  -14.9  19.1         3   1.8e+04     129     202 ..    1241    1322 ..    1220    1343 .. 0.70
   3 ?   -0.6   0.0     0.075   4.5e+02      96     218 ..    1518    1620 ..    1502    1710 .. 0.51
   4 !   61.1   6.0   1.4e-20   8.6e-17     107     417 ..    1730    2027 ..    1632    2047 .. 0.83

  Alignments for each domain:
  == domain 1  score: -12.6 bits;  conditional E-value: 3
         REJ  135 grnndnpllnidpeals......gtllssstssltfpaselvanltynftltvskrsrksasteqtilvvdgepplvsiecisncngkvnpndrlvl 225 
                  g n ++++ n+++ ++s       + ++ss +  t++ ++ ++n  +++  + s +  +s   +  il  + ++   s  ++   n+  n ++   +
  EFC37830.1 1075 GVNCNETAGNNQNLNVSnfgndtSISNNSSANNYTSFDNSTNSN--LTIFNNSSLDLNNSTNQNSSILSNTTNVDNSSNFTNLSNNTAFNSTSNCTI 1169
                  33333333333333333333333233333333333333334444..333333333334344444444444444444444444444555555555555 PP

         REJ  226 lasclncakd.lkdvtfeW..slsqtseeysllpdkatsslttgterprLvi 274 
                   ++c+n   + + +v+     s++ ++ ++++   + ++++ttg ++    i
  EFC37830.1 1170 GVYCNNTIGSsNGTVS--NnrSVDNSTFTNTTNFNNSYNNATTGIDNNSTSI 1219
                  5555554332222222..2235555555555555555555555555555555 PP

  == domain 2  score: -14.9 bits;  conditional E-value: 3
         REJ  129 rsqpmngrnndnpllnidpeals.gtllsssts.sltfpaselvanltynftltvskrs......rksasteqtilvvdgep 202 
                  +++++ng n +n+++++  + +   t+ +s+   s+ +++s+l++n t  +  t++ ++       ++++t+ t ++ ++ p
  EFC37830.1 1241 TNSNVNGTNLNNTMSTNSTVYNNnNTIANSTVFnSTISNNSTLNKNSTSSVNSTINNSTssnvnnSTTSTTNSTSTISTSPP 1322
                  3446999999999988887776644444444443666778899999999999999888866655544555555555555555 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.075
         REJ   96 gyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrsrksaste 192 
                  +  +++ +d+s Sy  d ++      ++ W++++s                ++++ + ++s +    t+++++      y f l++  +   + s +
  EFC37830.1 1518 SPCEQIAIDASGSYCGDLKP-----VKFIWSIESSP---------------DSNFNLQQVSFGDFNSTLTSNSISISGSYVFGLIAESSLSGARSEK 1594
                  33356666666666666555.....44666663333...............3333333333333333333333333334555555555554455555 PP

         REJ  193 qtilvvdgepplvsiecisncngkvn 218 
                  + i + ++ +p  +++  +n+  ++n
  EFC37830.1 1595 KFIEIIKSIVPNPTLSLLTNKMSLTN 1620
                  55555555555555555555544444 PP

  == domain 4  score: 61.1 bits;  conditional E-value: 1.4e-20
         REJ  107 eSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrsrksasteqtilvvdge.. 201 
                  e++Dpd  d+ ++++   W+c +   +n+  +d +++ni  + +      +++s+ ++p+ +l +     +tl ++k+ r s s +  i   + e  
  EFC37830.1 1730 ENSDPDNIDSVSDSW--NWSCFDRV-SNQACQDSTISNILTHYAI-----TKSSTCQIPKGSLSKV---SLTLSIQKGLR-SISKSLDIDYPNTEll 1814
                  468998888776777..8***6666.7788888888888777666.....7999*********988...69********9.9899999987777645 PP

         REJ  202 .pplvsiecisncngkvnpndrlvllas.cl..ncakd.lkdvtfeWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtd 293 
                   pp +s+  +   + kv + ++l l+ s  l  + +++  +d+  eWs+  +s ++s    k++ +++++++   L ++   L ++ +y++  +v+d
  EFC37830.1 1815 iPPVISLISVYPNRFKVLKDEVLSLQLSvILggDEKQTdEEDMIREWSINGNSLTNSM-ISKMSTQPSKSSS---LILSLLELLEDGEYEIEFQVSD 1907
                  58899988888889999999998777776541144455689999***66555555555.5558888888888...********************** PP

         REJ  294 kegkksglasisfkvnepPtgGtcsvtPlegvaletaftvrCqgwtDkdqPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvm 390 
                  ++ + s+  s+ fk+ + P ++ c ++P+ g+alet+f+++C g ++ +q   + +  + +++sg    ly+  ++    ++LP+++++  + ++ +
  EFC37830.1 1908 RRNNLSSRFSYKFKIVKSPKSCLCYINPSYGYALETEFSFSCPGCQNAEQSIDFVF-GFIDDKSGTKIPLYNLGEK--FASYLPSPFSS--NVMDTF 1999
                  ********************************************************.***************9888..89********4..5779** PP

         REJ  391 vsVyDnk.garvsvsltitVkppavnns 417 
                  v + D + ga+v+  ++++Vk p++++ 
  EFC37830.1 2000 VDIVDLDtGASVEFIKSVEVKTPTASSM 2027
                  *****7615666************9987 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   7.0    0.0001      0.62       5      32 .]     974    1000 ..     970    1000 .. 0.84
   2 !   21.5  10.0   3.8e-08   0.00023       4      32 .]    1011    1039 ..    1009    1039 .. 0.91
   3 !   19.6   8.6   1.5e-07   0.00089       5      32 .]    1052    1078 ..    1048    1078 .. 0.85
   4 !   13.4   8.4   1.3e-05     0.075       5      32 .]    1334    1360 ..    1330    1360 .. 0.84
   5 !   18.8   8.4   2.6e-07    0.0016       7      32 .]    1377    1401 ..    1372    1401 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.0001
       EGF_2    5 deiCgghGtCvnqcGq.CdCdsgyqGktC 32  
                  d  C+g+G C    +  C+C ++y+  +C
  EFC37830.1  974 DASCSGRGDCT--LNDfCECYDNYYAEDC 1000
                  778*******9..4345********9999 PP

  == domain 2  score: 21.5 bits;  conditional E-value: 3.8e-08
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+ghG Cv+++  C+C+++++G +C
  EFC37830.1 1011 NqSNVCNGHGECVDFN-SCKCKDNHYGEDC 1039
                  55799********999.7************ PP

  == domain 3  score: 19.6 bits;  conditional E-value: 1.5e-07
       EGF_2    5 deiCgghGtCvnqcGq..CdCdsgyqGktC 32  
                   + C+g+GtCv   G+  CdC+++y+G +C
  EFC37830.1 1052 ANVCNGNGTCV---GKdlCDCNQNYFGVNC 1078
                  579********...4555**********99 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 1.3e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ghG C +    C+C+s y G +C
  EFC37830.1 1334 SRVCSGHGNCFSND-SCQCNSLYEGVSC 1360
                  568*******8555.6**********99 PP

  == domain 5  score: 18.8 bits;  conditional E-value: 2.6e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+ghG+C ++   C+C+sgy+G  C
  EFC37830.1 1377 VCSGHGSCLSEDY-CQCESGYFGSRC 1401
                  7*******97775.***********9 PP

>> TMEM132D_C  Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   4.2e-05      0.25      34      69 ..    2425    2459 ..    2396    2467 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 4.2e-05
  TMEM132D_C   34 GmYaLlgvfClAilvflincvvyalkfrrkkvpveg 69  
                  G++ Ll v+C  i++++i+  ++  + rrkk ++e+
  EFC37830.1 2425 GLFGLLVVCCCGIMIVIISILIVR-CLRRKKRTFEK 2459
                  99****************987665.55555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2470 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1574  (0.0877907); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.55u 0.35s 00:00:01.90 Elapsed: 00:00:00.59
# Mc/sec: 12595.54
//
Query:       EFC37831.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1084  (0.0604607); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1170.99
//
Query:       EFC37832.1  [L=4488]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-16   60.6   2.1    3.7e-16   59.6   0.4    2.5  2  Laminin_G_3      Concanavalin A-like lectin/glucanases superf
    1.1e-07   31.5   4.5    1.1e-07   31.5   4.5    4.2  3  Ephrin_rec_like  Putative ephrin-receptor like
    2.4e-05   24.1   0.0    7.6e-05   22.5   0.0    1.8  1  Pentaxin         Pentaxin family
  ------ inclusion threshold ------
      0.028   14.6   0.1      0.082   13.1   0.1    1.8  1  OSTbeta          Organic solute transporter subunit beta prot
      0.066   13.8   0.7         70    4.1   0.0    5.2  4  TIG_2            TIG domain found in plexin
       0.17   12.0   0.0       0.17   12.0   0.0    3.7  4  Pox_A14          Poxvirus virion envelope protein A14


Domain annotation for each model (and alignments):
>> Laminin_G_3  Concanavalin A-like lectin/glucanases superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.6   0.4   1.3e-19   3.7e-16       6     151 ..     450     614 ..     445     615 .. 0.78
   2 ?   -2.8   0.1       2.1   6.3e+03      55     118 ..    1184    1250 ..    1144    1257 .. 0.71

  Alignments for each domain:
  == domain 1  score: 59.6 bits;  conditional E-value: 1.3e-19
  Laminin_G_3   6 yvtlpdaslptssfTvsaWvkpdslpsa..aqiiis.sssdgrgfelgldgsgrlrfsvnagng......aeesvtsgasvpageWtHvavtydggt. 93 
                   +++ ++++p++  Tv++W+  +s ++   +++ ++ + +++ +f++ l++  +l +s+n  +       a++s++++ ++++++W Hvav +++++ 
   EFC37832.1 450 RADVLNFPFPSTKVTVAFWLLSESEGNHleQGAPFAyQVNNT-YFGFVLTDYRSLKVSINEPHVlrylftASNSWDTTVNINSKTWRHVAVSWSSDSg 546
                  5556678899************99664422555444344555.999999998899999988877444444566999******************5555 PP

  Laminin_G_3  94 .lrlYvNGvevgsa.tltggllsatsgplviGrdp...gg.....ddpfdGlidevriynralsaaeI 151
                   l+lY++G+++  + +++ g + +++g+l+iG+     +g      d  +G+ide+ i++r+l++ eI
   EFC37832.1 547 lLKLYIDGTLKDFKlDYKKGQKIPPNGTLTIGNLRspgSGnvtffLDKVTGAIDEFVIFDRVLTDNEI 614
                  6********9999868888888899*******887655235555555566*****************9 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.1
  Laminin_G_3   55 g...rlrfsvnagngaeesvtsgasvpageWtHvavtydggtlrlYvNGvevgsatltggllsatsg 118 
                   +   +  f +n+ +++  s+  + +++  ++++ +v +dg+  +  +NG+  + ++  ++++s+  +
   EFC37832.1 1184 NvigSPFFVTNDVGSSTLSIYLKFKFSGAQYSYSCVSVDGSISSASFNGNSLNCTVSFPPVTSPRQN 1250
                   3454666777777777778889999999999999999999999999999977766655555544444 PP

>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   3.9   0.00023      0.68       9      31 ..    3622    3644 ..    3614    3644 .. 0.87
   2 !   31.5   4.5   3.7e-11   1.1e-07       8      48 .]    3638    3678 ..    3635    3678 .. 0.96
   3 ?    4.4   1.4     0.011        31       8      32 ..    3754    3775 ..    3749    3778 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00023
  Ephrin_rec_like    9 etCipCprgtYqneegqlsClaC 31  
                         C++C+ g+Y++  ++++C++C
       EFC37832.1 3622 DVCQECKPGFYKPINDSNACIPC 3644
                       56********************* PP

  == domain 2  score: 31.5 bits;  conditional E-value: 3.7e-11
  Ephrin_rec_like    8 letCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48  
                       ++ CipC  +tY ++ + ++C++CP +t t + ++ts ++C
       EFC37832.1 3638 SNACIPCDFNTYSSSFQAKECISCPVNTLTLQKASTSLTEC 3678
                       678************************************** PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.011
  Ephrin_rec_like    8 letCipCprgtYqneegqlsClaCP 32  
                       + +C +C  g+Y+ ++    C++C+
       EFC37832.1 3754 SGKCGACDVGYYKFNG---FCTKCG 3775
                       569*********9865...666665 PP

>> Pentaxin  Pentaxin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0   2.5e-08   7.6e-05      78     170 ..     527     621 ..     493     628 .. 0.81

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 2.5e-08
                 -SS-SSSEEEEEEEEETTTTEEEEEETTEEEEEE.E-STT--B-SSEEEEESS-BSCTTCTCSG.GGB--EEEEEEEEESS---HHHHHHHHHT- CS
    Pentaxin  78 vseekvepvhvCasWesssGivelwvdGkplvkk.slkkgytvgaeasiilGqeqDsyGGkfda.sqslvGelsdlnlWdyvLspeeiktvykga 170
                 v  +  +++hv +sW+s sG  +l++dG++   k   kkg  + ++  + +G  +    G+       + G + +  ++d vL+ +ei  + + +
  EFC37832.1 527 VNINSKTWRHVAVSWSSDSGLLKLYIDGTLKDFKlDYKKGQKIPPNGTLTIGNLRSPGSGNVTFfLDKVTGAIDEFVIFDRVLTDNEIGILATPS 621
                 3335568*********************99876626899*************999888887664256789******************8877665 PP

>> OSTbeta  Organic solute transporter subunit beta protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   2.7e-05     0.082      34      83 ..    4208    4257 ..    4205    4288 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.7e-05
     OSTbeta   34 WnysiLvLsavvvvisvvLLarsiqanRnrKiqpqeketpealyleeaka 83  
                  W  si++ + +v+v+++++  + ++++++rK+++  ++  e +y +e   
  EFC37832.1 4208 WIASIVIVVSIVLVLGMLIYDIYVRRKKDRKKERLARRELERKYGKEKAK 4257
                  99*******************************99999999999887643 PP

>> TIG_2  TIG domain found in plexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.56   1.7e+03      14      57 ..    1093    1141 ..    1091    1153 .. 0.73
   2 ?    1.0   0.0      0.23   6.8e+02      16      79 ..    2362    2428 ..    2350    2438 .. 0.72
   3 ?    4.1   0.0     0.024        70      30      71 ..    2500    2541 ..    2479    2557 .. 0.88
   4 ?    0.6   0.0      0.31   9.2e+02       5      56 ..    3408    3454 ..    3404    3472 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.56
       TIG_2   14 slkvknLpqpqseqkgykCvleiegaehelpakvesed.......titCqe 57  
                  sl ++n  ++    ++++C    +g+  + +a+v+s +        +tC++
  EFC37832.1 1093 SLLIQNVLPSN--VSNFQCLATSDGTLNQFSANVQSIQavsqtssLVTCGN 1141
                  67778877777..89999999999999888887776433333444777765 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.23
       TIG_2   16 kvknLpqpqseqkgykCvleiegaehelpakvesedtitCqe......mqysYegssgelevelsVvwng 79  
                  + + + +++  +  ykC ++  +a + ++a v   + +tC +      + ++ ++ ++ ++v+++++ n+
  EFC37832.1 2362 SLNSFGSME--NIVYKCAISSASALTAVDAFVV-GNVVTCPSltgsrkTFFDIYAITRAVSVPFKITSNQ 2428
                  444444444..556****************999.777777553333336678888899999999998865 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.024
       TIG_2   30 ykCvleiegaehelpakvesedtitCqemqysYegssgelev 71  
                  ++Cv++ ++a ++++ ++e    i +q+++y+Y ++ ++++v
  EFC37832.1 2500 LSCVFSTDTAVSKVNKMLELRLGIPDQSSNYQYLTNAKKIPV 2541
                  68*****************999***********999777665 PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.31
       TIG_2    5 vpvgvereislkvknLpqpqseqkgykCvleiegaehelpakves.edtitCq 56  
                  +  ++ +++++ ++nL           C+++i+++ ++++  ++s ++ i C+
  EFC37832.1 3408 LERNIPTSVTIVGENLGAAV------GCQFSISNQIVRVAKVLTSvSSEINCE 3454
                  55667777777777777766......9*********99999999845589996 PP

>> Pox_A14  Poxvirus virion envelope protein A14
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.4      0.15   4.3e+02      24      66 ..      41      83 ..      30      96 .. 0.78
   2 ?   -3.9   0.1       5.4   1.6e+04      44      75 ..    2253    2284 ..    2240    2290 .. 0.62
   3 ?   -4.4   1.7         6   1.8e+04      17      32 ..    3785    3800 ..    3781    3821 .. 0.71
   4 ?   12.0   0.0   5.8e-05      0.17      47      78 ..    4209    4240 ..    4197    4250 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.15
     Pox_A14 24 lacifafvdfskststtdkawralsivsFilgivillglllfs 66
                ++c++   d  k   + ++ + + +i++F++ ++++l + lf+
  EFC37832.1 41 TTCVYESNDDQKRLGKIRYSFSSSCILAFLMIMLLVLVIALFQ 83
                56666666666666667889999************99999986 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 5.4
     Pox_A14   44 wralsivsFilgivill..glllfsmygrkCkat 75  
                    ++s vsF+l   +l+  + ++ +  + +Ck++
  EFC37832.1 2253 VNSVSSVSFVLNYGSLVvpSAIVKN--NLYCKIS 2284
                  4689999999965544411444443..3467664 PP

  == domain 3  score: -4.4 bits;  conditional E-value: 6
     Pox_A14   17 aGiiLLilacifafvd 32  
                  +Gi++L++ +if  + 
  EFC37832.1 3785 FGILMLVVVLIFLLIS 3800
                  7888888888887664 PP

  == domain 4  score: 12.0 bits;  conditional E-value: 5.8e-05
     Pox_A14   47 lsivsFilgivillglllfsmygrkCkatssk 78  
                  ++ +  +++iv++lg+l+++ y r+ k ++++
  EFC37832.1 4209 IASIVIVVSIVLVLGMLIYDIYVRRKKDRKKE 4240
                  5567889***************9998655443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (4488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1070  (0.0596798); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.76u 0.35s 00:00:02.11 Elapsed: 00:00:00.59
# Mc/sec: 22967.44
//
Query:       EFC37833.1  [L=384]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (384 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1597  (0.0890736); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 2348.83
//
Query:       EFC37834.1  [L=669]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0058   16.7   0.5        4.9    7.3   0.0    2.7  2  SAM_2          SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
      0.079   13.2   0.8        2.6    8.3   0.1    2.9  2  Chordopox_A15  Chordopoxvirus A15 protein
       0.18   11.0   2.6       0.15   11.2   0.3    2.0  2  Dynamin_M      Dynamin central region


Domain annotation for each model (and alignments):
>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0   0.00081       4.9       4      52 ..      33      84 ..      30      95 .. 0.85
   2 !    6.9   0.1    0.0011       6.6       7      45 ..     518     563 ..     513     572 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00081
                HHHHHHHHHHHHT.TT.GGGHHHHHHTTCSHHHHHTTSCHHHH..HHTTHHHH CS
       SAM_2  4 wsledvaeWLrsi.gl.kqytdnFrdagitgaelllrlteedL..krlGitsv 52
                w+++   +WL+s+ g      +++++ +++g + l  ++ +dL  +r +++ +
  EFC37834.1 33 WDVDLFVKWLQSLeGVsTATIEKLKQEEWDG-RSLMCFSRSDLtsIRVPVSEA 84
                88888999*****66688999**********.***********6557777665 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0011
                 HHHHHHHHHT......TT.GGGHHHHHHTTCSHHHHHTTSCHHHHH CS
       SAM_2   7 edvaeWLrsi......gl.kqytdnFrdagitgaelllrlteedLk 45 
                  +++++L++i      ++   +t  F+++++  +e++  +t++dL 
  EFC37834.1 518 GSITKFLERIeligftDMrLTFTSQFLQNEFPNTEHITFHTHSDLD 563
                 6777888866666666788899**********************96 PP

>> Chordopox_A15  Chordopoxvirus A15 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.1     0.047   2.8e+02      31      61 ..     127     157 ..     111     159 .. 0.78
   2 ?    8.3   0.1   0.00044       2.6      27      56 ..     547     576 ..     537     578 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.047
  Chordopox_A15  31 rnsvtfsdevkideslksvllvnPsyidllk 61 
                    +n + +s+ v+ d++++svl  n  ++++l 
     EFC37834.1 127 SNTLFHSSLVDSDNDISSVLQKNSEITSILS 157
                    445566666**************99999986 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00044
  Chordopox_A15  27 pfparnsvtfsdevkideslksvllvnPsy 56 
                     fp+ +++tf+ ++++d+ + ++  +nPsy
     EFC37834.1 547 EFPNTEHITFHTHSDLDNFFLKIENINPSY 576
                    69***************************8 PP

>> Dynamin_M  Dynamin central region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.3   2.5e-05      0.15     123     243 ..     104     213 ..      98     227 .. 0.73
   2 ?   -1.7   0.1      0.23   1.4e+03     109     184 ..     497     575 ..     458     581 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.5e-05
   Dynamin_M 123 dfkklieGesevs.tkelsggarireiFnetlekslekidpleelsdeeirtairnsrGrelplfvpekaFealvkkqikkleepal..kcvelVyeel 218
                 +f+++++Ge++v+ t + s+g+r + +F++ l             sd++i+ ++++ + +++ l +pe++Fe+l +++i + ++p l  ++ e   + +
  EFC37834.1 104 SFNNATSGENDVQsTTSSSIGTRSNTLFHSSLVD-----------SDNDISSVLQKNSEITSILSLPESSFENLNENHIVQTHRPELfnDFSEFTVKVF 191
                 7999999998876699999999999999996654...........3579999****************************9999965223334444444 PP

   Dynamin_M 219 ekiveklekelkrFpnLreeikevv 243
                 +  +++     + Fp L ++ ++ v
  EFC37834.1 192 QLSLRR---LEQAFPPLSSRSQSLV 213
                 444444...3345566666666555 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.23
   Dynamin_M 109 ktklllqlitkfkedfkklieGe.se.vstkelsggarireiFnetle.kslekidpleelsdeeirtairnsrGrelp 184
                  ++++++++++  +  +    G+ ++ ++  el g++ +r  F++++  +++ +++ +   ++++  ++  +++ ++++
  EFC37834.1 497 HQHFVVDILSALGSLSNIKQLGSiTKfLERIELIGFTDMRLTFTSQFLqNEFPNTEHITFHTHSDLDNFFLKIENINPS 575
                 5556666666555433333345543435577899999999999997664555555555555566666666666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (669 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       699  (0.0389871); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 3982.27
//
Query:       EFC37835.1  [L=163]
Description: membrane protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-15   57.5   1.8    1.4e-15   57.5   1.8    1.7  2  PEMT        Phospholipid methyltransferase
    3.3e-09   37.0   0.7    4.4e-09   36.6   0.1    1.6  2  ICMT        Isoprenylcysteine carboxyl methyltransferase (ICM
     0.0015   17.4   0.7     0.0018   17.1   0.7    1.0  1  ERG4_ERG24  Ergosterol biosynthesis ERG4/ERG24 family
     0.0039   16.7   0.6     0.0047   16.5   0.6    1.2  1  DUF1295     Protein of unknown function (DUF1295)
     0.0043   16.6   0.1     0.0051   16.3   0.1    1.3  1  NnrU        NnrU protein


Domain annotation for each model (and alignments):
>> PEMT  Phospholipid methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.88   3.1e+03      58      69 ..      13      24 ..       6      35 .. 0.53
   2 !   57.5   1.8     4e-19   1.4e-15       9     105 ..      52     149 ..      44     150 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.88
        PEMT 58 gstlgflGlaLi 69
                +++l++l+++L+
  EFC37835.1 13 FTFLCMLAMYLF 24
                333333333333 PP

  == domain 2  score: 57.5 bits;  conditional E-value: 4e-19
        PEMT   9 lialglllvlssiealgefgtfygdfFlelmdklvtsGiYrylnnPeyvgstlgflGlaLitgsaaglllallvllvyl..ialkfvEephlakiYgkr 105
                  +++g+ ++l+  +++++++t+++ +  e++++lv++G+Yr+++nP+yvg +++++G++L+   ++++++ l ++++yl  + +   Ee++l++++g++
  EFC37835.1  52 SLMIGAGIALAGKYEFSKMKTTVNPMTPEKTSSLVQGGVYRWTRNPMYVGFLACLFGWSLFLMDWMVMVVFLPFFVWYLnkFQIE-PEERFLQELFGQE 149
                 46788899999999**********99888888****************************9999998777766666654104444.9*********985 PP

>> ICMT  Isoprenylcysteine carboxyl methyltransferase (ICMT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       2.4   8.7e+03      70      74 ..      17      21 ..       5      31 .. 0.49
   2 !   36.6   0.1   1.2e-12   4.4e-09      29      93 ..      78     143 ..      43     144 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.4
        ICMT 70 alvll 74
                +++ +
  EFC37835.1 17 CMLAM 21
                22221 PP

  == domain 2  score: 36.6 bits;  conditional E-value: 1.2e-12
        ICMT  29 i.lpdhklvksglykylrHPnYllfvilelatllLlcnakltalvllalvalllf.vRikeEekaLa 93 
                 + +++  lv+ g+y+++r P Y++ ++  l + +L++  +++ +v+l++ ++ l    i+ Ee+ L+
  EFC37835.1  78 TpEKTSSLVQGGVYRWTRNPMYVG-FLACLFGWSLFLMDWMVMVVFLPFFVWYLNkFQIEPEERFLQ 143
                 2578899*****************.899999************************99******9997 PP

>> ERG4_ERG24  Ergosterol biosynthesis ERG4/ERG24 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.7     5e-07    0.0018     292     424 ..       7     158 ..       2     163 .] 0.80

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 5e-07
  ERG4_ERG24 292 svhPselgwstvlvailvvlligyyiFrsansqknnFR....................tnPedpklkllkyiqtktGskLlvsGWyglarkinYlgDwl 370
                  v P+ + +   + a+++ ++++   F ++ s  n F                     ++ +  + ++++ ++ ++ s L+  G y+ +r++ Y+g + 
  EFC37835.1   7 KVPPVLFTFL-CMLAMYLFNIMTRNAFSLCSSDDNSFVmrlllfasslmigagialagKYEFSKMKTTVNPMTPEKTSSLVQGGVYRWTRNPMYVGFLA 104
                 5556666666.589999999999999**********9888************99999766666666678999999*********************999 PP

  ERG4_ERG24 371 qslswsLatgfqsvlpyfyvlyFlvlLvhRelRDeekCkkkYGedweeYkkkvp 424
                   + wsL     +v+  f + +   l       +e+  ++ +G+++ +Yk+kv+
  EFC37835.1 105 CLFGWSLFLMDWMVMVVFLPFFVWYLNKFQIEPEERFLQELFGQEFVNYKRKVK 158
                 99999998776666666666444444444444555567889***********97 PP

>> DUF1295  Protein of unknown function (DUF1295)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.6   1.3e-06    0.0047     145     234 ..      70     156 ..       6     157 .. 0.55

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1.3e-06
     DUF1295 145 f.....kkdpankgkvldsGLwrysRHPNYfg..ealiWwglflialealeglealaiagpllltlllvfvsgipllEkkalkkykdkeeyreYqkk 234
                         +p+    +++ G++r++R P Y g    l+ w+lfl+ + +      ++++ p ++ +l  f+  i + E+  ++ ++  +e+ +Y++k
  EFC37835.1  70 MkttvnPMTPEKTSSLVQGGVYRWTRNPMYVGflACLFGWSLFLMDWMV------MVVFLPFFVWYLNKFQ--IEPEERFLQELFG--QEFVNYKRK 156
                 333333457888888***************7722566667777776655......4555665554444333..5566655555555..666666665 PP

>> NnrU  NnrU protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   1.4e-06    0.0051      90     175 ..      73     160 ..      11     163 .] 0.75

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.4e-06
        NnrU  90 pgnplsvglka.......dlaetgivritrHPmllgvaiWAlaHllanGdlasvllfgglllwalvgviai.drr.krrrlgeewealaartsvv 175
                 + n       +       +l + g++r+tr Pm +g+    ++  l   d   ++ f  +++w l ++ +  ++r +++ +g+e+ +++++++ +
  EFC37835.1  73 TVN-------PmtpektsSLVQGGVYRWTRNPMYVGFLACLFGWSLFLMDWMVMVVFLPFFVWYLNKFQIEpEERfLQELFGQEFVNYKRKVKRW 160
                 234.......14444455999******************************************99888664133335666777777777776666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 983.44
//
Query:       EFC37836.1  [L=330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.051   13.6   3.6       0.11   12.6   3.6    1.5  1  Rootletin  Ciliary rootlet component, centrosome cohesion


Domain annotation for each model (and alignments):
>> Rootletin  Ciliary rootlet component, centrosome cohesion
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   3.6   5.9e-06      0.11      55     133 ..      36     141 ..       9     162 .. 0.59

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 5.9e-06
   Rootletin  55 l.............................ssareleeeesadleealakLeeErqrseklaqvnslLreqleearqaneaLtedlqkltkdwerlree 124
                                                s ++++e+   +  +  + +eeE  +s +  +vns L   l+e+  ++   t+d+  +++++ ++r++
  EFC37836.1  36 HqqnvtksasspnnrnpqhmidsfnsipthLSSSSRSEDVYCNSSNCSTLMEEEEIQSCN--SVNSSLTSSLDESCVSSSVCTNDVISISANFLKYRQQ 132
                 112222333333333333334555544433222344444444446777777776655444..6***********************************9 PP

   Rootletin 125 leqkekewr 133
                 ++ + ++  
  EFC37836.1 133 SNLNHSHQS 141
                 986655443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1712  (0.0954878); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2217.18
//
Query:       EFC37837.1  [L=361]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (361 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1386  (0.0773049); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 2250.40
//
Query:       EFC37838.1  [L=625]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        3.4    7.9   7.9       0.78    9.9   3.0    2.5  2  Pim       Pesticin immunity protein


Domain annotation for each model (and alignments):
>> Pim  Pesticin immunity protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   3.0   4.4e-05      0.78      17      89 ..      74     144 ..      59     150 .. 0.75
   2 ?   -2.0   0.2      0.23   4.2e+03      32      56 ..     433     457 ..     413     488 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 4.4e-05
         Pim  17 svaqgkdealakdilknlelntfrnslrpriygdqttlkqteyritekkagakktialvdkeqswvislkvle 89 
                 s      +a+   ilk +   ++  s +  +y++  +l+ t+ + t+  +++  t  ++++  s   s+ + +
  EFC37838.1  74 SSKTDTTTATQGAILKSVSSMSYASSSSSAHYPKS-SLNSTNVKSTNASTNTTATHPIIHQSSSN-SSVSIQQ 144
                 2333345566678********************96.79******************999987663.4565554 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.23
         Pim  32 knlelntfrnslrpriygdqttlkq 56 
                 +  +  t  n+l+    +  tt   
  EFC37838.1 433 ESTNSSTSDNALSRSSISSSTTTTS 457
                 5555555566666555555444332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (625 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2052  (0.114451); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.03u 0.38s 00:00:01.41 Elapsed: 00:00:00.56
# Mc/sec: 3344.53
//
Query:       EFC37839.1  [L=554]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   1.4e-139  453.7  18.4      4e-13   48.9   0.0   12.2 16  DUF4116       Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.11   12.6   1.1        1.1    9.4   0.1    3.1  4  CwsA          Cell wall synthesis protein CwsA
       0.17   11.5   0.1         60    3.3   0.0    4.1  5  PreAtp-grasp  Pre ATP-grasp domain
       0.44   10.6   1.8       0.83    9.7   0.0    2.4  2  DUF1154       Protein of unknown function (DUF1154)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.1     2e-07   0.00092       1      35 [.      39      73 ..      39      75 .. 0.95
   2 !   44.1   0.0   2.8e-15   1.2e-11       1      46 [.      64     110 ..      64     114 .. 0.96
   3 !   30.3   0.1   5.4e-11   2.4e-07       1      38 [.     130     169 ..     130     181 .. 0.87
   4 !   37.6   0.0     3e-13   1.3e-09       1      49 []     183     231 ..     183     231 .. 0.99
   5 !   37.0   0.0   4.5e-13     2e-09       3      49 .]     210     257 ..     208     257 .. 0.95
   6 !   22.3   0.0   1.8e-08   7.9e-05       1      31 [.     233     264 ..     233     266 .. 0.93
   7 !   47.9   0.1   1.8e-16   8.1e-13       1      49 []     259     307 ..     259     307 .. 0.98
   8 !   43.2   0.0   5.4e-15   2.4e-11       1      47 [.     309     355 ..     309     358 .. 0.95
   9 !   15.7   0.0     2e-06    0.0091       9      41 ..     342     374 ..     342     377 .. 0.88
  10 !   21.9   0.1   2.4e-08   0.00011       1      49 []     359     405 ..     359     405 .. 0.93
  11 !   36.5   0.5   6.6e-13     3e-09       1      49 []     382     431 ..     382     431 .. 0.93
  12 !   37.6   0.3   2.9e-13   1.3e-09       1      49 []     407     456 ..     407     456 .. 0.97
  13 !   45.3   0.0   1.2e-15   5.2e-12       1      49 []     433     481 ..     433     481 .. 0.97
  14 !   48.9   0.0     9e-17     4e-13       1      46 [.     458     503 ..     458     506 .. 0.97
  15 !   45.5   0.0     1e-15   4.6e-12       1      46 [.     483     528 ..     483     529 .. 0.96
  16 !   32.0   0.0   1.7e-11   7.6e-08       1      40 [.     508     547 ..     508     554 .] 0.93

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 2e-07
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35
                ++ ++l + ++n+  ++y+  e+ +D+++vlkAv 
  EFC37839.1 39 NKNFILAISSSNNDFFRYATREMLSDRNFVLKAVA 73
                799******************************96 PP

  == domain 2  score: 44.1 bits;  conditional E-value: 2.8e-15
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 Dr +vl+av +  g+al+++++eL nD+e++l+Av   g +l+y+s+
  EFC37839.1  64 DRNFVLKAVANTlGNALQFIPDELLNDREFILQAVGVRGGSLRYLSK 110
                 9*********999********************************97 PP

  == domain 3  score: 30.3 bits;  conditional E-value: 5.4e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk..qng 38 
                 DrEiv+ av  n ++l+y+s+++++++e++++ ++   ++
  EFC37839.1 130 DREIVKVAVLENAYSLQYASNSMRRNRELMIELIRetTDP 169
                 9*********************************944455 PP

  == domain 4  score: 37.6 bits;  conditional E-value: 3e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E++  av+++gs+l+++s+++k+ k iv+kA+ ++ ++++ aseeLr
  EFC37839.1 183 DEEFMGIAVERDGSILEFASPRIKSVKSIVKKAMSNYVYVFEDASEELR 231
                 99**********************************************8 PP

  == domain 5  score: 37.0 bits;  conditional E-value: 4.5e-13
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqng.talsyaseeLr 49 
                  iv++a++++ ++++ +seeL++D+e+v+ A++  g + ++++ eeL+
  EFC37839.1 210 SIVKKAMSNYVYVFEDASEELRSDRELVMHALELGGgNLYEHFGEELK 257
                 69********************************99899*******97 PP

  == domain 6  score: 22.3 bits;  conditional E-value: 1.8e-08
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivl 31 
                 DrE+v++a++   g+ ++++ eeLk+Dk+i+l
  EFC37839.1 233 DRELVMHALELGgGNLYEHFGEELKKDKNIIL 264
                 9*********99579***************98 PP

  == domain 7  score: 47.9 bits;  conditional E-value: 1.8e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+ i+l+++++n  ++++l++e++nDk+iv+ Av+++g+ l++as+ Lr
  EFC37839.1 259 DKNIILNVLSTNEDVFEHLDPEMRNDKDIVMCAVERDGNLLEHASDALR 307
                 99********************************************997 PP

  == domain 8  score: 43.2 bits;  conditional E-value: 5.4e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 D+++vl av++  +al+y+s++L++D e+v +Av  ng+a++y+ +e
  EFC37839.1 309 DKQVVLRAVTTSAEALEYASDDLRSDLEVVQQAVSTNGCAIEYVLDE 355
                 9******************************************9866 PP

  == domain 9  score: 15.7 bits;  conditional E-value: 2e-06
     DUF4116   9 vkkngsalky.lseeLknDkeivlkAvkqngtal 41 
                 v++ng+a++y l+e+Lk ++e++lk +  ++ a+
  EFC37839.1 342 VSTNGCAIEYvLDESLK-NRELLLKTISTYPQAI 374
                 789*******6688888.9*********999876 PP

  == domain 10  score: 21.9 bits;  conditional E-value: 2.4e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +rE+ l+ +++++ a+     e+++D++++l++++  +++++y++e+L+
  EFC37839.1 359 NRELLLKTISTYPQAIDG--TEFSSDRDFILQCIRDQPIIMEYVDESLQ 405
                 799999999999999988..89************************996 PP

  == domain 11  score: 36.5 bits;  conditional E-value: 6.6e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsyaseeLr 49 
                 Dr+++l++++  + + +y++e+L+ Dke++++++kq++  a++++ ee++
  EFC37839.1 382 DRDFILQCIRDQPIIMEYVDESLQTDKEFIKEIIKQSKgAAIEHLTEEMK 431
                 9**********************************988578899999875 PP

  == domain 12  score: 37.6 bits;  conditional E-value: 2.9e-13
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+++e++k+  g a+++l ee+k+D eiv+  ++ ++ al yasee++
  EFC37839.1 407 DKEFIKEIIKQSkGAAIEHLTEEMKSDQEIVMLSMEEYPAALQYASEEIK 456
                 9*********88799*********************************97 PP

  == domain 13  score: 45.3 bits;  conditional E-value: 1.2e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D Eiv+  ++ ++ al+y+see+kn+++ivlkAv  +g +l+y+se L+
  EFC37839.1 433 DQEIVMLSMEEYPAALQYASEEIKNNRDIVLKAVTVDGAVLDYCSEALK 481
                 67*******************************************9886 PP

  == domain 14  score: 48.9 bits;  conditional E-value: 9e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 +r+ivl+av+ +g +l y+se Lk+D+e+v++Av +ng alsyase
  EFC37839.1 458 NRDIVLKAVTVDGAVLDYCSEALKKDREVVMAAVGNNGQALSYASE 503
                 8********************************************8 PP

  == domain 15  score: 45.5 bits;  conditional E-value: 1e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 DrE+v+ av +ng al y+se ++nDkei+l A+k +g+a+ ++ e
  EFC37839.1 483 DREVVMAAVGNNGQALSYASEVFRNDKEIALLACKTYGFAFLMVGE 528
                 9***************************************998765 PP

  == domain 16  score: 32.0 bits;  conditional E-value: 1.7e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 D+Ei+l a+k++g+a+  + e+L++D +i+ +A++ +++ 
  EFC37839.1 508 DKEIALLACKTYGFAFLMVGESLRHDQDILEQAMETDPST 547
                 9***********************************9975 PP

>> CwsA  Cell wall synthesis protein CwsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0       3.7   1.7e+04      78      93 ..     145     160 ..     137     163 .. 0.70
   2 ?   -1.4   0.0      0.55   2.5e+03      69      96 ..     214     241 ..     207     246 .. 0.84
   3 ?   -1.0   0.1      0.42   1.9e+03      38      91 ..     322     362 ..     301     374 .. 0.56
   4 ?    9.4   0.1   0.00024       1.1      46      98 ..     412     468 ..     402     494 .. 0.85

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 3.7
        CwsA  78 ledarkkrrrkrplll 93 
                 l+ a+++ rr r+l++
  EFC37839.1 145 LQYASNSMRRNRELMI 160
                 6667777777777776 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.55
        CwsA  69 evvaglPqaledarkkrrrkrplllagv 96 
                 +++++   ++eda+++ r+ r+l++ ++
  EFC37839.1 214 KAMSNYVYVFEDASEELRSDRELVMHAL 241
                 56788888999************99875 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.42
        CwsA  38 eelrrryresrlarelaaaqeaiaqelaaaqevvaglPqaledarkkrrrkrpl 91 
                 e              l  a + +  +l   q++v++   a+e    +  + r+l
  EFC37839.1 322 E-------------ALEYASDDLRSDLEVVQQAVSTNGCAIEYVLDESLKNREL 362
                 3.............3444555555555555555555555555555555555555 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.00024
        CwsA  46 esrlarelaaaqeaiaqelaaaqevva....glPqaledarkkrrrkrplllagvav 98 
                 ++ +++  +aa e +++e+ + qe+v     + P+al+ a+++ ++ r+++l +v+v
  EFC37839.1 412 KEIIKQSKGAAIEHLTEEMKSDQEIVMlsmeEYPAALQYASEEIKNNRDIVLKAVTV 468
                 5667888899**************985333379********************9987 PP

>> PreAtp-grasp  Pre ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.14   6.3e+02      49      94 ..      49      94 ..      41      98 .. 0.83
   2 ?   -0.3   0.0      0.17   7.5e+02      39      77 ..     284     321 ..     279     367 .. 0.63
   3 ?    3.3   0.0     0.013        60      38      94 ..     381     437 ..     379     439 .. 0.89
   4 ?    0.5   0.0     0.097   4.3e+02      39      76 ..     458     495 ..     455     505 .. 0.84
   5 ?   -1.8   0.0      0.49   2.2e+03      71      97 ..     525     551 ..     523     553 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.14
  PreAtp-grasp 49 peeeFlrYvtaltgvdreslrvlvppagrlgsdlLsperlldpelv 94
                   +++F rY+t  +  dr+ +   v+ +  +  +++ +e l d e+ 
    EFC37839.1 49 SNNDFFRYATREMLSDRNFVLKAVANTLGNALQFIPDELLNDREFI 94
                  5789******999999999998888888888899999999888875 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.17
  PreAtp-grasp  39 dGDvlvlpvapeeeFlrYvtaltgvdreslrvlvppagr 77 
                   d D+++  v+ + ++l+++ + ++ d++ +   v+ + +
    EFC37839.1 284 DKDIVMCAVERDGNLLEHASDALRGDKQVVLRAVT-TSA 321
                   66777777777777777777776666555443322.222 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.013
  PreAtp-grasp  38 rdGDvlvlpvapeeeFlrYvtaltgvdreslrvlvppagrlgsdlLsperlldpelv 94 
                    d D ++ + + ++  ++Yv + +++d+e ++ ++ + +    + L++e+  d+e+v
    EFC37839.1 381 SDRDFILQCIRDQPIIMEYVDESLQTDKEFIKEIIKQSKGAAIEHLTEEMKSDQEIV 437
                   5789999999999999******************99999999999999999999886 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.097
  PreAtp-grasp  39 dGDvlvlpvapeeeFlrYvtaltgvdreslrvlvppag 76 
                   + D+++  v+++ + l+Y  + ++ dre +   v  +g
    EFC37839.1 458 NRDIVLKAVTVDGAVLDYCSEALKKDREVVMAAVGNNG 495
                   5699999*****************99998877765554 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 0.49
  PreAtp-grasp  71 lvppagrlgsdlLsperlldpelverl 97 
                   +v +  r+++d+L++++ +dp++v  +
    EFC37839.1 525 MVGESLRHDQDILEQAMETDPSTVVFI 551
                   556677899999999999999987655 PP

>> DUF1154  Protein of unknown function (DUF1154)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.5       1.5   6.8e+03      10      17 ..     254     261 ..     254     261 .. 0.87
   2 ?    9.7   0.0   0.00018      0.83      10      27 ..     402     419 ..     397     423 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.5
     DUF1154  10 esLkqdKa 17 
                 e+Lk+dK+
  EFC37839.1 254 EELKKDKN 261
                 789***96 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00018
     DUF1154  10 esLkqdKaylKllKKQqK 27 
                 esL++dK++ K + KQ+K
  EFC37839.1 402 ESLQTDKEFIKEIIKQSK 419
                 89***************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (554 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       662  (0.0369234); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.80u 0.35s 00:00:01.14 Elapsed: 00:00:00.57
# Mc/sec: 2919.64
//
Query:       EFC37840.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.1e-11   43.0   0.1    6.9e-11   42.3   0.1    1.4  1  CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) a
    0.00024   21.4   2.9    0.00024   21.4   2.9    2.6  2  Histone        Core histone H2A/H2B/H3/H4
  ------ inclusion threshold ------
      0.055   13.6   1.8      0.083   13.0   1.8    1.2  1  DUF4719        Domain of unknown function (DUF4719)
          3    6.7   9.1      0.075   12.0   1.9    1.7  2  DUF5427        Family of unknown function (DUF5427)


Domain annotation for each model (and alignments):
>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.3   0.1   1.5e-14   6.9e-11       3      65 .]      82     145 ..      80     145 .. 0.98

  Alignments for each domain:
  == domain 1  score: 42.3 bits;  conditional E-value: 1.5e-14
                    XXHHHHHHHHHCC.TTXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF   3 LPiarvkkImksd.pdarkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65 
                    LP ++v ++++   pd+ ++++d k  ++++++ fi +l++ A+e ++k kr t++a++++ A+
     EFC37840.1  82 LPRSNVLRVIRRIiPDEVQLSNDTKLAFSKAAVVFIMYLTATAQEQATKHKRSTLTADDVLEAL 145
                    9***********************************************************9986 PP

>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   2.9   5.4e-08   0.00024      60     127 ..      80     144 ..      17     146 .. 0.84
   2 ?    2.2   0.6     0.049   2.2e+02      35      57 ..     158     180 ..     150     184 .. 0.76

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 5.4e-08
                 XXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXSEEXHHHHHHH CS
     Histone  60 lliqklpfaRvvreivksekedlrisaeavlalqealEallvelfeeAnllakhaKRvTitpkDiqlA 127
                 ++ ++  + Rv+r i +   ++  +s+++ la+ +a+  +++ l+ +A+  a + KR+T+t+ D+  A
  EFC37840.1  80 FDLPRSNVLRVIRRIIP---DEVQLSNDTKLAFSKAAVVFIMYLTATAQEQATKHKRSTLTADDVLEA 144
                 5667788899*****99...999*****************************************9887 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.049
                 B--TTT-XTTHHHHHHHHHHHHX CS
     Histone  35 kkkkrryrpgtvalkeirkyqks 57 
                  ++  +yr++++a+ke+ ++ k+
  EFC37840.1 158 VRTLNQYRQSQKAKKEKTTSKKR 180
                 45667889999999999888775 PP

>> DUF4719  Domain of unknown function (DUF4719)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   1.8   1.8e-05     0.083      72     142 ..      22      92 ..      15     109 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.8e-05
     DUF4719  72 gqrpgppggagplggarrpddddd.spallrdeaaatsqdslldssgsgrgrgsgarsdiscesehelrvvs 142
                  q+ + pg  gp  g+ r   +   + +  +  +a++s  sl +s+ +g   g g +s       ++lrv+ 
  EFC37840.1  22 QQQQSTPGKRGPKKGSTRGGSSAGnRTSHQQTVSASASSSSLANSTSGGGDGGEGEYS-FDLPRSNVLRVIR 92 
                 4667889999**9999998776651455555556666777777755544444556666.4444444666654 PP

>> DUF5427  Family of unknown function (DUF5427)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.8       0.2     9e+02      62     106 ..      30      57 ..      14      73 .. 0.31
   2 ?   12.0   1.9   1.7e-05     0.075      17      72 ..     123     179 ..     100     189 .. 0.55

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.2
     DUF5427  62 kaspkkkksaeepakeekkkeeessedkrksvestrslea.setps 106
                 k+ pkk +                 ++   s   +r+ ++ + ++s
  EFC37840.1  30 KRGPKKGS-----------------TR-GGSSAGNRTSHQqTVSAS 57 
                 11111111.................11.111111111111111222 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 1.7e-05
     DUF5427  17 kkkkktkkkkkakkkdeediLaeLeeLakkesrpaTPrvksn..kskkaspkkkksae 72 
                 +++++++k+k+++ ++ +d+L+ L+eL+  e + +  r+ ++  +s+ka+++k++s++
  EFC37840.1 123 TAQEQATKHKRSTLTA-DDVLEALDELELGEYKDEMVRTLNQyrQSQKAKKEKTTSKK 179
                 3333444444444444.4*******999966666655555443222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1539  (0.0858386); expected 358.6 (0.02)
Passed bias filter:                      695  (0.038764); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1062.52
//
Query:       EFC37841.1  [L=145]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (145 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       426  (0.0237604); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 899.05
//
Query:       EFC37842.1  [L=113]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (113 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       513  (0.0286129); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.52
# Mc/sec: 650.72
//
Query:       EFC37843.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-26   91.6  15.4    6.2e-26   91.6  15.4    2.4  2  MBOAT     MBOAT, membrane-bound O-acyltransferase family


Domain annotation for each model (and alignments):
>> MBOAT  MBOAT, membrane-bound O-acyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.4     0.029   5.1e+02      14      38 ..     138     162 ..      80     180 .. 0.68
   2 !   91.6  15.4   3.4e-30   6.2e-26      16     302 ..     140     411 ..     126     462 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.029
       MBOAT  14 llltlalsvltlqlialvlslydgl 38 
                 l++t   +  tl+ i+++++ ydg+
  EFC37843.1 138 LDFTGLQMLATLKTISVAWNIYDGM 162
                 4445555555555555555555555 PP

  == domain 2  score: 91.6 bits;  conditional E-value: 3.4e-30
       MBOAT  16 ltlalsvltlqlialvlslydgl.eketeltedvkellklllisyfvvgflelklhslslvfrklasaallsklpslleylgYvffyplllvGPilsys 113
                 +t   +  tl+ i+++++ ydg+  +++e + + ++ +                                  ++p+lley+ Y ff+p+ l+GPi++ s
  EFC37843.1 140 FTGLQMLATLKTISVAWNIYDGMiAQSDEKMNYYHKVNR-------------------------------MERMPGLLEYFSYMFFFPSILTGPIYEIS 207
                 566666666666666666666664455566666666663...............................456************************** PP

       MBOAT 114 eymsfvesplsrllyta...................krnfavalyalflgltylilieyv..l.skicakdftifkmlssaqllmrsvimrilllllll 190
                 +y++ +  ++ ++ +                     ++n+ +a    +l +++++ i ++  l   i+++ +++ ++ s    l +++++ ++ +++++
  EFC37843.1 208 DYLRMIYGEFDEDISFLnkmelkpnrqnppihwkkiFTNLLIAMVNMVL-TLKALPIFDRpqLeDVIYDRVGDQQLFGS---SLLYKLAFSWACMVAIK 302
                 *******99999977768899*************996666666666555.56777776653331467888888888887...46677777777777777 PP

       MBOAT 191 fllifdflglwlvalgedilsGlgvng......arldrvadrniygdwenavsfsefwraWNipvhkWLlryvYkplgskkfklnkslatlatFlfsAv 283
                 f  i    g+++ +  ++i++G+g+++          ++  + +      + + +++  +WN++v+kWL++yvY ++gs     ++  +t++tFl+sA 
  EFC37843.1 303 FKYIV---GWCWSES-AMIICGMGYQKdrktdqYSYAGCESIEYLNHL-LSSNLRDITTTWNVSVSKWLRNYVYSRVGS----GAGTKNTIITFLVSAS 392
                 77766...7777777.7********99***99999999********87.****************************86....899************* PP

       MBOAT 284 wHglalgyliwfvlrvlll 302
                 wHgl++gy++    ++++l
  EFC37843.1 393 WHGLYSGYYVMWTNYAICL 411
                 ********99544333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       789  (0.0440069); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 2811.09
//
Query:       EFC37844.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-34  117.5   0.0    6.4e-34  117.3   0.0    1.1  1  YjeF_N    YjeF-related protein N-terminus


Domain annotation for each model (and alignments):
>> YjeF_N  YjeF-related protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.3   0.0   3.6e-38   6.4e-34       2     171 .]      27     202 ..      26     202 .. 0.91

  Alignments for each domain:
  == domain 1  score: 117.3 bits;  conditional E-value: 3.6e-38
      YjeF_N   2 eeLmenagravaevlrallg..nspaekkvlvlvGsgnnGgdglaaArhLaqegakVtvllleeeekldedaeralellkkaggkvveekpeedleekl 98 
                 ++Lme ag +v+++  +++   +  ++ k l+++G+gnnGgdgl++ArhL q g++ +vl  ++e+ +++  +r l +++++ + ++ e+++  le+  
  EFC37844.1  27 DQLMELAGLSVSHACVEAFPlsGLKNGGKCLIVCGPGNNGGDGLVCARHLKQFGYSPIVLYPKKEAAQKDLYKRLLLQCTHFSIPIHYETNSPLLED-- 123
                 79***********88888877878888899*****************************888888899999****************9998888865.. PP

      YjeF_N  99 sapvdlviDAllGiglr..gelreelaeliewlnss..eapvlavDiPSGldadtGavsgta...vkadvtvtfgapkrg 171
                  ++ d ++DA++G++++  + +re+++++i++l++   ++p+l++D+PSG+d+d+ +++++    +++dv+v++  pk++
  EFC37844.1 124 -SSFDFIVDAIFGYSFSgkQGIREPFKTVIDTLKKPgnNTPILSIDLPSGWDVDNENIEENLqigLRCDVIVSLPSPKKC 202
                 .56***********77633789*************998999******************655667*************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       320  (0.0178482); expected 358.6 (0.02)
Passed bias filter:                      307  (0.0171231); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1561.15
//
Query:       EFC37845.1  [L=479]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.2e-22   77.9  17.1    1.6e-05   24.7   0.0    6.1  6  NHL          NHL repeat
     0.0071   16.2   0.1        3.5    7.7   0.1    3.2  3  PQQ          PQQ enzyme repeat
  ------ inclusion threshold ------
      0.017   14.3   0.4        1.2    8.3   0.0    2.4  2  DUF5128      6-bladed beta-propeller
       0.05   13.5   0.3       0.13   12.2   0.3    1.7  1  Shugoshin_N  Shugoshin N-terminal coiled-coil region
      0.099   11.9   0.1       0.68    9.1   0.1    2.3  2  Lactonase    Lactonase, 7-bladed beta-propeller
       0.23   11.5   1.1       0.47   10.5   1.1    1.5  1  BmKX         BmKX


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.1   6.4e-06     0.019       1      28 []     189     217 ..     189     217 .. 0.98
   2 ?   -2.9   0.1       3.1   9.2e+03       1       9 [.     294     302 ..     294     306 .. 0.68
   3 !   13.4   0.5     2e-05      0.06      15      27 ..     315     327 ..     313     328 .. 0.92
   4 !   15.7   0.0   3.7e-06     0.011       1      26 [.     350     375 ..     350     377 .. 0.95
   5 !   16.7   0.8   1.8e-06    0.0053       1      26 [.     401     427 ..     401     427 .. 0.97
   6 !   24.7   0.0   5.3e-09   1.6e-05       7      28 .]     456     478 ..     453     478 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 6.4e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 f++P ++a++ ++  i+V D +n+r+qvF
  EFC37845.1 189 FYCPCDIAISyNSSTILVLDMGNNRIQVF 217
                 89999***********************9 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.1
                 BSSEEEEEE CS
         NHL   1 fnyPhGvav 9  
                 fn P+G + 
  EFC37845.1 294 FNLPSGMVC 302
                 788999876 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 2e-05
                 EEEEECCCTEEEE CS
         NHL  15 iyVaDsenhrvqv 27 
                 +yV+D++n+rvq+
  EFC37845.1 315 LYVCDCNNNRVQI 327
                 8***********8 PP

  == domain 4  score: 15.7 bits;  conditional E-value: 3.7e-06
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 f  P+++ ++  G+++V++   hr+q
  EFC37845.1 350 FKGPWSIDLNARGEVIVCEVDGHRLQ 375
                 678**********************9 PP

  == domain 5  score: 16.7 bits;  conditional E-value: 1.8e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvq 26 
                 fn+P+++++d   ++i+V+D  n+r++
  EFC37845.1 401 FNHPRSIVIDkVRNNIIVCDQDNNRIV 427
                 9************************95 PP

  == domain 6  score: 24.7 bits;  conditional E-value: 5.3e-09
                 EEEE.TTTEEEEEECCCTEEEEE CS
         NHL   7 vavd.snGdiyVaDsenhrvqvF 28 
                 ++++  +G++yVaD++nhrvq+F
  EFC37845.1 456 LCLNeFSGELYVADFCNHRVQIF 478
                 5666668***************9 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.1   9.3e+03       5      17 ..     250     262 ..     247     263 .. 0.78
   2 !    4.9   0.0    0.0091        27       3      36 ..     315     349 ..     313     351 .. 0.90
   3 !    7.7   0.1    0.0012       3.5       1      23 [.     414     437 ..     414     440 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.1
                 EEETTSEEEEEET CS
         PQQ   5 lgsadGylyAlDa 17 
                 + ++d ++y +D+
  EFC37845.1 250 ISCNDHCIYKYDL 262
                 5678889**9997 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0091
                 EEEE.ETTSEEEEEETTTCCEEEEEESSSCGSSES CS
         PQQ   3 vylg.sadGylyAlDadTGkvlWrfktggpvlslp 36 
                 +y++ ++++++  l  ++G++l +  + ++v+s +
  EFC37845.1 315 LYVCdCNNNRVQILRTSNGNLLESIGETPEVDSIF 349
                 79********************9999999999876 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0012
                 TEEEEE.ETTSEEEEEETTTCCEE CS
         PQQ   1 gvvylg.sadGylyAlDadTGkvl 23 
                 ++++++ +++++++ l+ +TG+v+
  EFC37845.1 414 NNIIVCdQDNNRIVSLNNTTGDVV 437
                 799**************999*986 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.0   0.00039       1.2      58     128 ..     197     262 ..     180     279 .. 0.63
   2 ?    3.6   0.1      0.01        31     103     130 ..     406     433 ..     400     478 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00039
     DUF5128  58 ikvvdkrifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknkiltYdL 128
                 i +  + i+vlD+ +n++ vF++  ++ + I+     P  +l i+  +  k+n+ ++i +   + i +YdL
  EFC37845.1 197 ISYNSSTILVLDMGNNRIQVFTTGWRYRTTINL----PAKHLCIEPNFDGKKNDALIISCN-DHCIYKYDL 262
                 444456666666666666666666666666665....555666665555555555555555.566666666 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.01
     DUF5128 103 dfiidksnesIyildfmknkiltYdLeg 130
                 +++idk  ++I++ d+ +n+i++ + ++
  EFC37845.1 406 SIVIDKVRNNIIVCDQDNNRIVSLNNTT 433
                 5566666666666666666655544333 PP

>> Shugoshin_N  Shugoshin N-terminal coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.3   4.2e-05      0.13       4      19 ..     106     121 ..     105     124 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 4.2e-05
  Shugoshin_N   4 kylrqNreLAKsNsal 19 
                  +ylrqN+e+AK+   +
   EFC37845.1 106 NYLRQNKEIAKNVTVR 121
                  7**********98765 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.45   1.3e+03     248     271 ..     194     217 ..     169     222 .. 0.45
   2 ?    9.1   0.1   0.00023      0.68     285     327 ..     396     436 ..     312     443 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.45
                 EEEE-TTSSEEEEEETSSTEEEEE CS
   Lactonase 248 eIrlspdgkflyvSnRgadsiavf 271
                 +I++s +++ + v + g++ i vf
  EFC37845.1 194 DIAISYNSSTILVLDMGNNRIQVF 217
                 333333333333333333333333 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00023
                 EEE-SSS.--EEEE-TTSSEEEEEETTTTEEEEEEEETTTTEE CS
   Lactonase 285 evstegkfPRdfaldpsgklllvanqksdnvtvferdaetGkL 327
                  +s+  ++PR++++d+  + ++v++q+ ++++  + +++tG +
  EFC37845.1 396 GYSSSFNHPRSIVIDKVRNNIIVCDQDNNRIV--SLNNTTGDV 436
                 46677789******************999876..556677765 PP

>> BmKX  BmKX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   1.1   0.00016      0.47       7      29 ..      43      65 ..      42      66 .. 0.94

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00016
        BmKX  7 kakgeAamCTaGtddkaGTCTaC 29
                k+ g+ + CT  t d+ G C  C
  EFC37845.1 43 KTNGNVQHCTSSTMDQKGHCSRC 65
                89999999**************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (479 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       690  (0.0384851); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 3049.91
//
Query:       EFC37846.1  [L=415]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.5    7.9  26.0        2.6    7.1  26.0    1.4  1  SOG2      RAM signalling pathway protein
          3    5.9  16.9        5.2    5.1  16.9    1.5  1  Hid1      High-temperature-induced dauer-formation protein


Domain annotation for each model (and alignments):
>> SOG2  RAM signalling pathway protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  26.0   0.00029       2.6     194     348 ..     111     284 ..      75     338 .. 0.51

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00029
        SOG2 194 saesstesrassvtytartRhagsfsaqdveqGaalt.....plrsd.qipfnlsrsrrssssgnsaspaangaqsetsersasssgvqssasstPlge 286
                   + +++++ ++ t+     ++   s+ d +    ++      ++s  q + n  ++r+ss+s+n++++ +  aq+++s +  s ++++s++ + P   
  EFC37846.1 111 HLTNNQQPNIGTLTNQTS-QSSNQRSVLDTNGAVDMPtdyndGSPSLfQEKKNKRKTRASSRSRNTINSESPSAQTPSSSSDESPDENSSNKRTPPKRR 208
                 333333333343332222.22223344555555555554444233333333333445555555555555555554444444444444444444433333 PP

        SOG2 287 gstsp..............p.galsrqslsttgststltsssksrsssrsntnasastprslattpappasaesfas 348
                 +++++                +a +++ + +t++ s+++ss++ +s+ +++tn ++ + + l++tp +++s+++  s
  EFC37846.1 209 AKSTAieaiaelaqsdtesVdVAVPKSKALRTEKRSSPSSSKQTNSTLSTSTNKQQEDVAQLNETPTTSSSSNKK-S 284
                 333335555555555555433444555555555555566555555544444455555555555555533333331.1 PP

>> Hid1  High-temperature-induced dauer-formation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1  16.9   0.00058       5.2     574     713 ..     169     305 ..      89     348 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.00058
        Hid1 574 ltlesaseeiersne..sarldsideeeeenssessrieesrsesrspslsevpelksslaitddeskaereksatessssqavsqlremsekarakes 670
                 ++ ++++  i+++    ++ + s de+ +enss++ + +++r+  +s   +++ el +s  ++ d +  +++   te++ss++ s +++ s  ++++++
  EFC37846.1 169 SSRSRNT--INSESPsaQTPSSSSDESPDENSSNKRTPPKRRA--KSTAIEAIAELAQSDTESVDVAVPKSKALRTEKRSSPSSS-KQTNSTLSTSTNK 262
                 2222333..2222222234444444444444444444444333..3334567777777777777777777777777777776555.6666777777777 PP

        Hid1 671 aesteesrqesatskkspsgmsqsaeekftptsewlesWkskl 713
                 ++++  + +e+ t ++s ++ s+++ ek  +t ++ +sW   l
  EFC37846.1 263 QQEDVAQLNETPTTSSSSNKKSSEYIEKARKTDSLTRSWTVTL 305
                 7777777777777777778888899999999999999998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (415 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2243  (0.125105); expected 358.6 (0.02)
Passed bias filter:                      650  (0.0362541); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.91u 0.38s 00:00:01.29 Elapsed: 00:00:00.53
# Mc/sec: 2358.21
//
Query:       EFC37847.1  [L=382]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
        3.7    7.8   6.8         20    5.4   4.5    2.3  2  DUF4611         Domain of unknown function (DUF4611)
        7.8    7.0  14.0         43    4.6  10.1    2.3  2  CENP-B_dimeris  Centromere protein B dimerisation domain


Domain annotation for each model (and alignments):
>> DUF4611  Domain of unknown function (DUF4611)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0     0.026   2.4e+02      67      78 ..      92     103 ..      51     113 .. 0.71
   2 ?    5.4   4.5    0.0023        20      52      87 ..     343     377 ..     337     381 .. 0.47

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.026
     DUF4611  67 egededdeeeek 78 
                 + +d+dde +ek
  EFC37847.1  92 HHDDDDDEANEK 103
                 344444444444 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0023
     DUF4611  52 qeaqddvaaagdeeeegededdeeeekniknktksd 87 
                 +e   +     ++eee++++ddee ++n ++ + s+
  EFC37847.1 343 REVGSTDFG-SSSEEEDDEDDDEEYQENADTFSDSE 377
                 554333333.33444444444455455556655555 PP

>> CENP-B_dimeris  Centromere protein B dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.1    0.0088        79      30      60 ..      93     128 ..      83     156 .. 0.59
   2 ?    4.6  10.1    0.0048        43      10      42 ..     348     380 ..     339     382 .] 0.59

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.0088
  CENP-B_dimeris  30 edeeddedddevpvpsfgeam.....ayfamvkryl 60 
                     +d++dde ++++ +  + ++m      yf m   y 
      EFC37847.1  93 HDDDDDEANEKLGMNRIAKSMrevlwIYFEMCSAYD 128
                     566666666666665555544222245888887774 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0048
  CENP-B_dimeris  10 edsesesdeeeeeeeedeededeeddedddevp 42 
                      d  s s+ee++e++++e +e+ +   d++e p
      EFC37847.1 348 TDFGSSSEEEDDEDDDEEYQENADTFSDSEEEP 380
                     455566666665555555555556666777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (382 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       956  (0.0533214); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 2283.55
//
Query:       EFC37848.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-19   68.2  10.5    5.6e-05   22.9   0.0    6.2  7  LRR_6            Leucine Rich repeat
    5.9e-16   58.0   7.6    6.8e-07   29.0   1.0    3.8  3  LRR_8            Leucine rich repeat
    1.2e-10   41.5  12.5    0.00046   20.5   1.0    4.6  3  LRR_4            Leucine Rich repeats (2 copies)
    2.5e-09   36.4   1.8       0.71   10.6   0.1    6.4  7  LRR_1            Leucine Rich Repeat
    0.00032   20.2   3.0     0.0043   16.6   0.1    2.2  2  LRR_9            Leucine-rich repeat
  ------ inclusion threshold ------
      0.034   14.1   0.3      0.067   13.1   0.3    1.5  1  F-box-like       F-box-like
      0.054   13.2   0.1       0.11   12.3   0.1    1.5  1  DUF1647          Protein of unknown function (DUF1647)
      0.099   12.8   0.3       0.21   11.8   0.3    1.5  1  HU-CCDC81_euk_2  CCDC81 eukaryotic HU domain 2
       0.12   12.3   1.7       0.36   10.8   1.7    1.9  1  F-box            F-box domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       7.8   1.6e+04      11      19 ..       4      12 ..       4      13 .. 0.75
   2 !    9.4   0.0   0.00057       1.1       5      24 .]      91     110 ..      88     110 .. 0.91
   3 !   16.2   0.0   3.9e-06    0.0078       3      24 .]     113     134 ..     111     134 .. 0.90
   4 ?   -1.0   0.1       1.3   2.5e+03       3      10 ..     137     144 ..     135     144 .. 0.78
   5 !   22.9   0.0   2.8e-08   5.6e-05       3      24 .]     163     184 ..     161     184 .. 0.91
   6 ?    1.3   0.1      0.23   4.6e+02       4      23 ..     188     207 ..     185     208 .. 0.77
   7 !   19.7   0.1   2.8e-07   0.00056       4      23 ..     212     231 ..     210     231 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 7.8
       LRR_6 11 sgNdIgDeG 19
                s++ I+D+ 
  EFC37848.1  4 SHHVIDDDI 12
                677899985 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00057
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+ +N++g e ++ ++
  EFC37848.1  91 LTVLDIHYNNLGSEDIKHIS 110
                 9*************999885 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 3.9e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +L+ Ld++ Nd+g+eGa+ ++
  EFC37848.1 113 KKLRILDITANDFGNEGAKYIS 134
                 58****************9885 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.3
       LRR_6   3 thLteLdL 10 
                 + Lt+Ld+
  EFC37848.1 137 NQLTHLDM 144
                 56999996 PP

  == domain 5  score: 22.9 bits;  conditional E-value: 2.8e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + L++L++s N+IgDeGa++++
  EFC37848.1 163 QQLRYLEISENEIGDEGAKSIS 184
                 67*****************996 PP

  == domain 6  score: 1.3 bits;  conditional E-value: 0.23
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+L + +N+Ig  Ga+ +
  EFC37848.1 188 QLTTLLILSNNIGHIGAQYI 207
                 57888888999998888765 PP

  == domain 7  score: 19.7 bits;  conditional E-value: 2.8e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+L++s NdIg eGa+ +
  EFC37848.1 212 QLTSLNISNNDIGVEGAKHI 231
                 69***************986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.3   3.7e-07   0.00075      24      61 .]      88     125 ..      83     125 .. 0.92
   2 !   19.8   0.3   2.4e-07   0.00048      21      61 .]     159     199 ..     154     199 .. 0.93
   3 !   29.0   1.0   3.4e-10   6.8e-07       2      55 ..     188     241 .]     187     241 .] 0.98

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 3.7e-07
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +++L+vLd+ +N+l + + + +s+L++Lr Ld++ N++
  EFC37848.1  88 MKQLTVLDIHYNNLGSEDIKHISQLKKLRILDITANDF 125
                 789*************9999**************9985 PP

  == domain 2  score: 19.8 bits;  conditional E-value: 2.4e-07
                 STT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  21 FkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                   ++++L++L++s+N++    ++++s+L++L+ L + +N++
  EFC37848.1 159 IGNMQQLRYLEISENEIGDEGAKSISQLNQLTTLLILSNNI 199
                 579*******************************9999987 PP

  == domain 3  score: 29.0 bits;  conditional E-value: 3.4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 +Lt+L + +N++ +++ +   ++++L++L++snN + +  ++ +++L++L++L+
  EFC37848.1 188 QLTTLLILSNNIGHIGAQYIGRMNQLTSLNISNNDIGVEGAKHIHSLKQLTYLY 241
                 79**************************************************97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   1.0   2.3e-07   0.00046       1      39 [.      89     125 ..      89     153 .. 0.86
   2 !   11.2   0.7   0.00019      0.39       1      36 [.     163     199 ..     163     204 .. 0.80
   3 !   12.1   0.2    0.0001       0.2       2      29 ..     212     241 .]     211     241 .] 0.81

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 2.3e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L+vLd++ N+l + +   +++l++L+ Ld++ N    d+
  EFC37848.1  89 KQLTVLDIHYNNLGSEDIkhISQLKKLRILDITAN----DF 125
                 58*************99997778*********888....44 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00019
                 SS--EEE--SS---E-S-..HHH-TT--EEE-...-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdL..sgNnli 36 
                 ++L++L +s N + d +   +++l +L++L L  s+N  i
  EFC37848.1 163 QQLRYLEISENEIGDEGAksISQLNQLTTL-LilSNN--I 199
                 58*************99986667999***8.654666..5 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 0.0001
                 S--EEE--SS---E-S-..HHH-TT--EEE CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLd 29 
                 +L++L++snN +   +   + +l++L++L+
  EFC37848.1 212 QLTSLNISNNDIGVEGAkhIHSLKQLTYLY 241
                 69***********66666555799999986 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0         9   1.8e+04      13      21 ..      17      25 ..       9      26 .. 0.69
   2 ?    6.2   0.1      0.01        20       1      21 [.      90     110 ..      90     112 .. 0.80
   3 ?    4.6   0.0     0.035        69       1      21 [.     114     134 ..     114     136 .. 0.81
   4 ?   -0.1   0.0       1.2   2.4e+03       1       8 [.     138     145 ..     138     147 .. 0.83
   5 ?    5.9   0.0     0.013        26       1      22 [.     164     185 ..     164     186 .. 0.89
   6 ?    0.9   0.0      0.58   1.1e+03       4      18 ..     191     205 ..     188     210 .. 0.62
   7 !   10.6   0.1   0.00036      0.71       1      23 []     212     234 ..     212     234 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 9
       LRR_1 13 lglppnsfq 21
                l++++++f+
  EFC37848.1 17 LSFHSDDFK 25
                367777776 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld+ +n+l++  + +++
  EFC37848.1  90 QLTVLDIHYNNLGSEDIKHIS 110
                 599********9877777665 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.035
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +Lr Ld++ n +++ ++ +++
  EFC37848.1 114 KLRILDITANDFGNEGAKYIS 134
                 7******99999877777666 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 1.2
       LRR_1   1 nLrhLdLs 8  
                 +L+hLd++
  EFC37848.1 138 QLTHLDMC 145
                 59****96 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +Lr+L +s n +++ ++ s++ 
  EFC37848.1 164 QLRYLEISENEIGDEGAKSISQ 185
                 59**********9999999876 PP

  == domain 6  score: 0.9 bits;  conditional E-value: 0.58
       LRR_1   4 hL.dLsnnpllglppn 18 
                 +L  Lsnn++ +++++
  EFC37848.1 191 TLlILSNNIG-HIGAQ 205
                 5515688876.76665 PP

  == domain 7  score: 10.6 bits;  conditional E-value: 0.00036
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++L++snn ++  ++ ++++L
  EFC37848.1 212 QLTSLNISNNDIGVEGAKHIHSL 234
                 599*********99999999986 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.5    0.0055        11      62     146 ..      62     143 ..      54     149 .. 0.71
   2 !   16.6   0.1   2.2e-06    0.0043      14     118 ..     131     240 ..     122     241 .] 0.75

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0055
       LRR_9  62 llkrlktlllnnnri.vriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                 +l+ + tl ++n  +  +   ++ e + +l+ l +  n+l +  d++ + +lkkl++l +  n   n+       i k++ql+ ld
  EFC37848.1  62 FLQNIVTLKVENRDLsFKFDCKILELMKQLTVLDIHYNNLGS-EDIKHISQLKKLRILDITANDFGNEGA---KYISKMNQLTHLD 143
                 677777777766554246677777888888888888888876.688888999999988888888776643...3355666666555 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 2.2e-06
       LRR_9  14 qyinaire.reldlrgykipvienlGa....tldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqelad 105
                 +yi  + +   ld+ gy  p+ +  Ga     + q+  +++s+n+i +    ++  l++l tll+ +n i +i+ +    + +l++l ++nn +   + 
  EFC37848.1 131 KYISKMNQlTHLDMCGYLYPI-DMGGAkyigNMQQLRYLEISENEIGDegAKSISQLNQLTTLLILSNNIGHIGAQYIGRMNQLTSLNISNNDIGVEGA 228
                 555555442457777776665.22233111146899999*******7623678999*************************************986555 PP

       LRR_9 106 ldPlaslkklell 118
                  + + slk+l++l
  EFC37848.1 229 -KHIHSLKQLTYL 240
                 .778888888876 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.3   3.4e-05     0.067       6      36 ..      10      43 ..      10      53 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.4e-05
  F-box-like  6 dEiLlqIFsyLppsd....LlrlalVCrrWrrval 36
                d+iL +I+s+    d      ++alV+++W  +++
  EFC37848.1 10 DDILGEILSFH-SDDfkfiAMSCALVSKQWLKIVR 43
                6899999*973.2225554777********99984 PP

>> DUF1647  Protein of unknown function (DUF1647)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   5.4e-05      0.11      25     116 ..      76     171 ..      65     177 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.4e-05
     DUF1647  25 iGkkFdCslvetleklklleeeeklvdlsel..ikneedvvFvsatsddhlkeakksiksirkyypkk.klilysldls.eeeieklkkdknlevr 116
                 +  kFdC+++e +++l +l+ + + +  +++  i++ +++     t++d+ +e  k i+ ++++ + +    ly +d+  +++i ++++ + le+ 
  EFC37848.1  76 LSFKFDCKILELMKQLTVLDIHYNNLGSEDIkhISQLKKLRILDITANDFGNEGAKYISKMNQLTHLDmCGYLYPIDMGgAKYIGNMQQLRYLEIS 171
                 5679****************9766654444311556677888899999999999999999999876540457888888625677788877777775 PP

>> HU-CCDC81_euk_2  CCDC81 eukaryotic HU domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.3   0.00011      0.21      46      73 ..      63      90 ..      46      91 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00011
  HU-CCDC81_euk_2 46 fkgiGvLsirnrkvkmkFyesflesleg 73
                     +++i +L+++nr +++kF+ ++le +++
       EFC37848.1 63 LQNIVTLKVENRDLSFKFDCKILELMKQ 90
                     4599******************998875 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   1.7   0.00018      0.36       8      44 ..      10      49 ..       8      53 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00018
                HHHHHHHHHTS-HHH.....HHHHCTT-HHHHHHHTTHHHHH CS
       F-box  8 sevlrhILerLplsd.....llalrrVSkgwrilidsdrlwc 44
                +++l +IL++  +sd       ++++VSk w +++++     
  EFC37848.1 10 DDILGEILSF--HSDdfkfiAMSCALVSKQWLKIVRERCKLS 49
                6788888888..7778999999*************9877655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       477  (0.0266049); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1624.94
//
Query:       EFC37849.1  [L=402]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       503  (0.0280551); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2460.34
//
Query:       EFC37850.1  [L=878]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-19   69.3  31.1     0.0011   18.7   0.0    9.9 10  RCC1_2        Regulator of chromosome condensation (RCC1) rep
    1.2e-16   61.1  29.6    1.6e-07   31.8   0.0    9.7 10  RCC1          Regulator of chromosome condensation (RCC1) rep
    3.4e-06   27.3   5.4    9.2e-06   25.9   5.4    1.7  1  EGF_2         EGF-like domain
      0.002   18.1   3.5     0.0056   16.7   3.5    1.8  1  EGF_Tenascin  Tenascin EGF domain
  ------ inclusion threshold ------
       0.11   12.9   2.2       0.31   11.4   2.2    1.8  1  EGF           EGF-like domain


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0     0.065   2.3e+02      12      21 ..     172     181 ..     168     182 .. 0.80
   2 ?    4.1   0.0     0.012        43      11      27 ..     232     248 ..     230     249 .. 0.88
   3 !   17.4   0.1   7.6e-07    0.0027       5      29 ..     282     306 ..     280     307 .. 0.88
   4 !   18.7   0.0   3.1e-07    0.0011       1      28 [.     331     358 ..     331     360 .. 0.91
   5 ?    1.3   1.3     0.091   3.3e+02      18      27 ..     398     410 ..     397     412 .. 0.69
   6 !    7.5   0.2     0.001       3.7      12      29 ..     442     459 ..     434     460 .. 0.91
   7 !   11.4   0.0   5.9e-05      0.21       1      25 [.     542     566 ..     542     569 .. 0.87
   8 !   12.0   0.0   3.9e-05      0.14       5      30 .]     592     618 ..     588     618 .. 0.88
   9 !    8.9   0.9   0.00036       1.3      12      27 ..     659     674 ..     657     676 .. 0.87
  10 ?   -3.9   0.1       3.7   1.3e+04      22      27 ..     812     817 ..     810     817 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.065
      RCC1_2  12 caLtedGeVl 21 
                 ++Lt+dG+V+
  EFC37850.1 172 LILTSDGKVF 181
                 669*****97 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.012
      RCC1_2  11 scaLtedGeVlcWGsNs 27 
                 ++aLt+ G+V+++G+ +
  EFC37850.1 232 YFALTNYGHVFSFGCGD 248
                 79************965 PP

  == domain 3  score: 17.4 bits;  conditional E-value: 7.6e-07
      RCC1_2   5 saGdyHscaLtedGeVlcWGsNsdG 29 
                 s+G++   a++ dG++++WGsN +G
  EFC37850.1 282 SSGRSVMAAIDKDGKLYTWGSNYRG 306
                 567777789*************998 PP

  == domain 4  score: 18.7 bits;  conditional E-value: 3.1e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsd 28 
                 Vk++ +G++H++ ++e+G+V+ +G+N+ 
  EFC37850.1 331 VKKIHFGVSHALTILENGNVYVFGDNDA 358
                 788889********************86 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.091
      RCC1_2  18 GeVlcWG...sNs 27 
                 G++++WG   +++
  EFC37850.1 398 GNLYSWGygrQDN 410
                 99*****444455 PP

  == domain 6  score: 7.5 bits;  conditional E-value: 0.001
      RCC1_2  12 caLtedGeVlcWGsNsdG 29 
                 +++t++G  + WG N dG
  EFC37850.1 442 VSVTSEGMAYVWGTNRDG 459
                 789*************99 PP

  == domain 7  score: 11.4 bits;  conditional E-value: 5.9e-05
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGs 25 
                 ++s+  G+   ++L+++G++++WGs
  EFC37850.1 542 IVSIELGNQVGFILLSNGDLYGWGS 566
                 677778888899************8 PP

  == domain 8  score: 12.0 bits;  conditional E-value: 3.9e-05
      RCC1_2   5 s.aGdyHscaLtedGeVlcWGsNsdGQ 30 
                 + +Gd+  ++L+ +G Vl+ G+Ns+ Q
  EFC37850.1 592 AlIGDDNIFFLMKNGSVLGIGRNSNYQ 618
                 558*********************987 PP

  == domain 9  score: 8.9 bits;  conditional E-value: 0.00036
      RCC1_2  12 caLtedGeVlcWGsNs 27 
                 + Lt+ G+V+++G+N+
  EFC37850.1 659 LLLTNQGNVYGCGNND 674
                 5699**********97 PP

  == domain 10  score: -3.9 bits;  conditional E-value: 3.7
      RCC1_2  22 cWGsNs 27 
                 c+G Ns
  EFC37850.1 812 CFGYNS 817
                 9**997 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.2     0.003        11       2      12 ..     239     249 ..     238     251 .. 0.91
   2 !   31.8   0.0   4.6e-11   1.6e-07       1      50 []     294     344 ..     294     344 .. 0.92
   3 !   11.6   0.0   9.6e-05      0.34       1      44 [.     347     389 ..     347     395 .. 0.82
   4 ?    3.2   1.3     0.038   1.4e+02       2      12 ..     398     408 ..     397     422 .. 0.83
   5 !   10.4   0.0   0.00021      0.76       1      36 [.     447     487 ..     447     501 .. 0.80
   6 ?   -2.5   0.0       2.4   8.6e+03      26      47 ..     527     552 ..     522     555 .. 0.69
   7 ?    0.7   0.2      0.23   8.2e+02       1       9 [.     558     566 ..     558     569 .. 0.87
   8 ?    4.8   0.1     0.012        44       1      18 [.     605     622 ..     605     631 .. 0.89
   9 ?    4.1   0.4      0.02        73       2      12 ..     665     675 ..     664     677 .. 0.89
  10 ?   -0.0   0.2       0.4   1.4e+03       1      14 [.     754     767 ..     754     767 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.003
                 TEEEEEE--GG CS
        RCC1   2 GrVysWGrndy 12 
                 G+V+s+G++dy
  EFC37850.1 239 GHVFSFGCGDY 249
                 99********8 PP

  == domain 2  score: 31.8 bits;  conditional E-value: 4.6e-11
                 TTEEEEEE--GGGTTSSSS-..--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt..esvlvPtkveglsgnrvvkvacGddhtval 50 
                 dG++y+WG+n +G +G  +t  +   +P++v++l++ +v+k+  G +h + +
  EFC37850.1 294 DGKLYTWGSNYRGSMGVNDTslDYTETPRQVTLLPS-KVKKIHFGVSHALTI 344
                 9****************9998766688********8.***********9865 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 9.6e-05
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEET CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGd 44 
                 +G+Vy +G nd  q+     + v+vP+k++  ++ +v+   + +
  EFC37850.1 347 NGNVYVFGDNDAQQCDPSAGQVVWVPRKMSYINS-NVTECYASG 389
                 69*************99999999******99987.666655555 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.038
                 TEEEEEE--GG CS
        RCC1   2 GrVysWGrndy 12 
                 G++ysWG + +
  EFC37850.1 398 GNLYSWGYGRQ 408
                 99*****8876 PP

  == domain 5  score: 10.4 bits;  conditional E-value: 0.00021
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS.....- CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgn.....r 36 
                 +G  y WG n +G L  g + +  +P+ ++ +s n      
  EFC37850.1 447 EGMAYVWGTNRDGILAKGEEREIRYPRNLTIPSMNisnsvS 487
                 6889****************9999***99988877664333 PP

  == domain 6  score: -2.5 bits;  conditional E-value: 2.4
                 EEE-GGGTTS....-EEEEEEETTEE CS
        RCC1  26 Ptkveglsgn....rvvkvacGddht 47 
                 P+k ++ s+n    ++v++  G++  
  EFC37850.1 527 PVKESLISSNltkqEIVSIELGNQVG 552
                 555555555566669****9999865 PP

  == domain 7  score: 0.7 bits;  conditional E-value: 0.23
                 TTEEEEEE- CS
        RCC1   1 dGrVysWGr 9  
                 +G++y+WG+
  EFC37850.1 558 NGDLYGWGS 566
                 69******6 PP

  == domain 8  score: 4.8 bits;  conditional E-value: 0.012
                 TTEEEEEE--GGGTTSSS CS
        RCC1   1 dGrVysWGrndyGqLGlg 18 
                 +G+V++ Grn+++q G g
  EFC37850.1 605 NGSVLGIGRNSNYQFGFG 622
                 69************9987 PP

  == domain 9  score: 4.1 bits;  conditional E-value: 0.02
                 TEEEEEE--GG CS
        RCC1   2 GrVysWGrndy 12 
                 G+Vy++G+nd+
  EFC37850.1 665 GNVYGCGNNDN 675
                 9********97 PP

  == domain 10  score: -0.0 bits;  conditional E-value: 0.4
                 TTEEEEEE--GGGT CS
        RCC1   1 dGrVysWGrndyGq 14 
                 +G++y+ G ndy q
  EFC37850.1 754 KGNLYAGGVNDYFQ 767
                 59*********977 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   5.4   2.6e-09   9.2e-06       5      32 .]     820     846 ..     816     846 .. 0.90

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 2.6e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+ +G+C +++  C+Cd gy+Gk C
  EFC37850.1 820 ALACSSRGYCAAPN-SCVCDEGYFGKEC 846
                 678********999.7************ PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   3.5   1.5e-06    0.0056       4      28 ..     821     846 ..     819     847 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.5e-06
  EGF_Tenascin   4 LGCssRGvCvD.GqCiCDsEYsGDDC 28 
                   L CssRG C     C+CD  Y G +C
    EFC37850.1 821 LACSSRGYCAApNSCVCDEGYFGKEC 846
                   88*******86268**********99 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   2.2   8.7e-05      0.31       5      31 ..     819     844 ..     815     845 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 8.7e-05
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                 +   Cs +G C        +C C+eGy+Gk
  EFC37850.1 819 NalaCSSRGYCA----APNSCVCDEGYFGK 844
                 4466*******4....5559*********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (878 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       406  (0.0226449); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.77u 0.28s 00:00:01.05 Elapsed: 00:00:00.51
# Mc/sec: 5217.93
//
Query:       EFC37851.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2456  (0.136985); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 1104.16
//
Query:       EFC37852.1  [L=483]
Description: hypothetical protein NAEGRDRAFT_81826 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.037   14.3   0.1       0.21   11.9   0.1    2.1  1  HSA       HSA


Domain annotation for each model (and alignments):
>> HSA  HSA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   1.2e-05      0.21      14      52 ..     412     465 ..     406     466 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.2e-05
                 HHHHHTTHHHHHHHHHHHHH...............HHHHHHHHHHHHHHH--XX CS
         HSA  14 ylLeeilwhakdfkeerksk...............rakakklaravakyhnnie 52 
                 +lL ++++h++ f+ + +++               +ak +k+a ++a +h++  
  EFC37852.1 412 DLLGHMINHYNVFITNLYNNqnplppiynqsrmnyQAKTQKIADSIALFHQDLD 465
                 899***********************************************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       615  (0.034302); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 2845.68
//
Query:       EFC37853.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       788  (0.0439511); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1602.92
//
Query:       EFC37854.1  [L=1080]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.4e-22   77.8   1.3    2.4e-21   76.2   1.3    1.7  1  DUF676        Putative serine esterase (DUF676)
    1.3e-05   25.2   0.0    3.6e-05   23.7   0.0    1.8  1  Palm_thioest  Palmitoyl protein thioesterase
      0.001   18.6   0.2      0.045   13.2   0.0    2.4  2  Nodulin       Nodulin
     0.0012   19.3   0.3      0.011   16.3   0.3    2.8  1  DUF3657       Protein FAM135
     0.0023   17.7   0.0     0.0048   16.6   0.0    1.6  1  PGAP1         PGAP1-like protein


Domain annotation for each model (and alignments):
>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.2   1.3   6.8e-25   2.4e-21       4     214 ..     709     932 ..     707     939 .. 0.77

  Alignments for each domain:
  == domain 1  score: 76.2 bits;  conditional E-value: 6.8e-25
      DUF676   4 kdhLvVlvHGlqgnsaDlelikeqlekikeklpee...kieflm......sennesktfkgidvlgerlaeevlevvkkkkdknkkiSfvghSlGglia 93 
                 k hL++++ G ++++ D+   k+ l +    +p++     ++++      +  +++   + i+++++ + +e+ +++++++    k+Sf+ hSlGg+i+
  EFC37854.1 709 KNHLIIFIPGYKSSHYDFVTFKTILGLH---FPDDrhqFYIVKSldklhtKDTSSELHNAPIKIMAKLVTDEITQMIQENEIFFHKVSFICHSLGGIIM 804
                 78***********************995...44442213333331111103333444456799********************99************** PP

      DUF676  94 raaiaklkekemt.lkeaikglepvtfitlasPhLGv............lysskslinlglalleklkkslsmeqlgltGrdLflkddkdeknsllykl 179
                 r+a  + + + +t ++      +++tf++l+ PhLG+             + s++l+  g+++l+  kk   ++ l+++  +  +kd+kd+k ++    
  EFC37854.1 805 RSAFYYFRPSWKTvFP------YLHTFVSLSVPHLGIgpiktlinkdneSFASNNLVRAGIWFLKSFKKEKCLQELSME-DHSDVKDSKDNKTNYESHK 896
                 *****99987765577......9*************75555544444434678889***********************.8888887777776665444 PP

      DUF676 180 lkdek..dlkliealklFkrrvlyanvvndrivplas 214
                 l++    +l++ ++l+ Fk+++l+++  +d +vp++s
  EFC37854.1 897 LEQCLlfKLSMTNDLSWFKQVLLIGSE-QDTYVPIES 932
                 44432113567888***********66.******998 PP

>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0   9.9e-09   3.6e-05      46     199 ..     769     935 ..     714     979 .. 0.70

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 9.9e-09
  Palm_thioest  46 sffgnlndqveavckk.lelangfhaiGfSQGglflRaliercddkkn.....vrnlislggpqaGvfglllckvaekllasgavysklvqkslvqa 136
                    + + ++d++++++++ + + +++ +i++S Gg+++R       +  +     +++++sl+ p+ G+  +       k l ++   ++++ ++lv a
    EFC37854.1 769 IMAKLVTDEITQMIQEnEIFFHKVSFICHSLGGIIMRSAFYYFRPSWKtvfpyLHTFVSLSVPHLGIGPI-------KTLINK-DNESFASNNLVRA 857
                   45566778888888878556789***************9999976665899****************887.......333333.3566666667777 PP

  Palm_thioest 137 qywrdpe.kleeYlkknkFLpdiNnerdha....knetyk...............knllkleklvlvgfsdDtvvvPkeSslf 199
                   + w  ++ k e+ l++ + + d  + +d++    +   y+               + l+  ++++l+g+++Dt v P eS+l+
    EFC37854.1 858 GIWFLKSfKKEKCLQELS-MEDHSDVKDSKdnktN---YEshkleqcllfklsmtNDLSWFKQVLLIGSEQDTYV-PIESALI 935
                   766555555456665555.5555555555432220...2233333344443433367777888888888888876.7777765 PP

>> Nodulin  Nodulin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.021        75     109     141 ..      10      42 ..       5      53 .. 0.86
   2 !   13.2   0.0   1.3e-05     0.045       8     129 ..      61     186 ..      55     199 .. 0.70

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.021
     Nodulin 109 mvpstrllnnqqlgqgfyyfqyepllqfrtvlr 141
                 mv   r++n   l +g+yy++ e   +f  v r
  EFC37854.1  10 MVNMERFINSGMLHKGYYYVRVEVNPRFGKVNR 42 
                 89999****************998888877766 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 1.3e-05
     Nodulin   8 fkkfvtdgtshvaercssgsealhgegglalclfdsmenclvehgaakvnq...rslfvlpkgst..piepkdslpsfipsppippkskf..ecwcesl 99 
                 +kk    ++sh   + s     lh +g +   l d   n ++ h +         +  v  + ++   +   ds  ++i spp pp++ +  +      
  EFC37854.1  61 YKK--GSSASHNNSHSSCSNSNLHHDGSIDASLSDFHINSFILHSSKDGRSgkyDANHVNNNSASdfSVRFVDS-TAIITSPPTPPNATVlsQSLMRNG 156
                 444..35678888888888899*****************99999865432210123344444433114566676.5799*******9976224455666 PP

     Nodulin 100 iscvctwtsmvpstrllnnqqlgqgfyyfq 129
                 i      t    +tr+ nn +l q fy   
  EFC37854.1 157 IDLSMNQTVKEETTRVYNNSKLSQVFYIRY 186
                 778888899999*************99533 PP

>> DUF3657  Protein FAM135
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.3   3.1e-06     0.011      12      65 ..     227     298 ..     216     299 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.1e-06
     DUF3657  12 n..................enqkeepelqndlksvstrklkinnalegiheyvPvlFdefhfclvnvtihss 65 
                 +                   + k ++ + nd+ +v+ r+++i +a +g    +P +F+ ++++ v+ +ih +
  EFC37854.1 227 KeevqreekkfekamhsnkYEYKIKQLDVNDFVKVADRTITIRKAMRGYNIAYPAIFENWYYSIVKSSIHCV 298
                 555555555555555554422335677899****************************************76 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   1.3e-06    0.0048       7     130 ..     713     833 ..     708     915 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.3e-06
       PGAP1   7 VlFvpGnagsykqvrslAseaaeayqelrkllknqnkkeldfftvdfneelsaldGrtlldqaeylndaIkyIlslysssekeptsviliGHSmGGiva 105
                 ++F+pG   s+ +   +  +   ++ ++r++    ++   + +t d+  el     +++    +++ d   +I+++ +++e   ++v  i HS+GGi+ 
  EFC37854.1 713 IIFIPGYKSSHYDFVTFKTILGLHFPDDRHQFYIVKSL-DKLHTKDTSSELHNAPIKIMA---KLVTD---EITQMIQENEIFFHKVSFICHSLGGIIM 804
                 78888888888888888888855555555444433322.346788888877777666665...66555...5666999********************* PP

       PGAP1 106 raaltlkn....yikqsvntiltlasPha 130
                 r+a+ + +     +    +t ++l+ Ph 
  EFC37854.1 805 RSAFYYFRpswkTVFPYLHTFVSLSVPHL 833
                 ***99876433333345688888888885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1080 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1313  (0.0732333); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.80u 0.32s 00:00:01.12 Elapsed: 00:00:00.48
# Mc/sec: 6779.99
//
Query:       EFC37855.1  [L=448]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-12   47.5   1.2    3.1e-12   46.3   1.1    1.7  1  D123      D123
    0.00086   20.0   2.8      0.002   18.8   0.7    2.5  2  E1_UFD    Ubiquitin fold domain


Domain annotation for each model (and alignments):
>> D123  D123
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.3   1.1   3.4e-16   3.1e-12     114     280 ..     221     403 ..     211     422 .. 0.76

  Alignments for each domain:
  == domain 1  score: 46.3 bits;  conditional E-value: 3.4e-16
                 -BSSHHHHHHHHHT-HHHHHHHHHTTTTBT--TTS-S-TT.----EEEEE----.-GGGEEEEEEE......TTEEEEEEESSS.S--THHHHT..HHH CS
        D123 114 kctsvndvylLLksSdfiahDLehafdeceeeeeesekee.ieleLvLrkwfdl.npslefRcFVk......drkLiaisqRdl.nyydfleel..kee 201
                  ++++   + L   S+ +  DL +a   ++e+ +++++ e    + v r + ++ +p++efR+FVk      ++++ +i+q     y + +++   ke+
  EFC37855.1 221 CVQNAMQAMNLVIHSERMYADLFRALLFIDEKLKKTPECElPGQKFVARLFKKMkRPEYEFRVFVKyfekemKHQVTGITQYFRtCYLEDIQHGtlKEQ 319
                 5555555555666677777777666555533333333333255668999999773589*******8655555689******766467777776557*** PP

                 HHHHHHHHHHT..TTTSSSSSEEEEEEEETT..........EEEEEEEEESSTTS--TTS-HHHHH.....HS-TTSSS-EEE---- CS
        D123 202 lkekieeffeeklkekfpdesyvfDvyvpkk........ldkvkliDinpfaertdslLFtweeLleeeeeeeeeeeeepelrlves 280
                 +++ iee+ +e+ k   + e++v+Dv v+ +        ++k+++i in f+++  +++F+w++     ++e    ++ +e+r++++
  EFC37855.1 320 IQKGIEELAQEVSKRLSTTENFVLDVSVEYDknetgdctVSKIWMIEINSFSKQASPCMFDWNDPV---SNEILMGNRPMEFRVLTK 403
                 **********988888889*******99999999*****************************977...567777778888888855 PP

>> E1_UFD  Ubiquitin fold domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.7   2.3e-07     0.002       9      90 ..     278     359 ..     269     362 .. 0.80
   2 ?   -0.5   0.1      0.23     2e+03      47      70 ..     410     433 ..     403     445 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 2.3e-07
      E1_UFD   9 eitlkelldyfkekkklevsmislgvsllYasflpkkkdkerlklklselveevtkkkipphqkyldlevsvedeegedvev 90 
                 e   + +++yf++++k +v+ i++     Y + +++   ke++++ + el +ev+k+    +  +ld++v  +++e  d++v
  EFC37855.1 278 EYEFRVFVKYFEKEMKHQVTGITQYFRTCYLEDIQHGTLKEQIQKGIEELAQEVSKRLSTTENFVLDVSVEYDKNETGDCTV 359
                 5667889*******************9999999999*******************998555444455555555544567765 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.23
      E1_UFD  47 dkerlklklselveevtkkkipph 70 
                   e+l +++ e++ee+++  +p+ 
  EFC37855.1 410 GREELAKDIREMLEEINGAVPPEA 433
                 5688999********997765554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (448 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       808  (0.0450667); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.26s 00:00:00.83 Elapsed: 00:00:00.43
# Mc/sec: 3099.86
//
Query:       EFC37856.1  [L=539]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-22   79.8   0.1    5.4e-22   78.4   0.1    1.8  1  HATPase_c     Histidine kinase-, DNA gyrase B-, and HSP90-lik
    5.7e-15   55.5   0.1    1.3e-14   54.3   0.1    1.6  1  Response_reg  Response regulator receiver domain
    3.1e-08   33.5   0.1    7.9e-08   32.2   0.1    1.8  1  HisKA         His Kinase A (phospho-acceptor) domain


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.4   0.1     9e-26   5.4e-22       1     111 [.     144     290 ..     144     291 .. 0.83

  Alignments for each domain:
  == domain 1  score: 78.4 bits;  conditional E-value: 9e-26
                 EHHHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE.............EE.......TEEEEEEEESSSSSTTHHHTGTCSTTCH................ CS
   HATPase_c   1 gdekrLrqiisnlvdNavkfatkageieveika.............se.......ddlvisveDnGiGipkedlkklfekfsq................ 63 
                 gd  rL qi+ n+v+N+vk+ tk+g+i +++++             ++         l+++ +D+GiGip +d+ +lf +f +                
  EFC37856.1 144 GDHVRLSQILLNFVSNSVKY-TKKGSIMLNCTVcdktdedypflegRSiidteefICLKVTCQDTGIGIPTKDIRNLFRPFHTvdgasmdferyysysv 241
                 6889****************.9*****998888766655444444300455557899999***************999999999999999988877765 PP

                 .HCSTCHT..STSSSHHHHHHHHHHHHTTTEEEEEEETTTEEEEEEEEESS CS
   HATPase_c  64 .ddstkrg..gggtGlGlsivkklvelmgGeiwvesepgrGttftftlple 111
                  ++++  g  ++ +G+Gls++++++elm+G+i++ese g Gt++t+++pl+
  EFC37856.1 242 iNQNR--GsfHESHGIGLSLSNQFIELMNGKINFESEIGVGTKVTIYIPLK 290
                 43333..24589*************************************97 PP

>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.3   0.1   2.2e-18   1.3e-14       1      80 [.     455     536 ..     455     538 .. 0.93

  Alignments for each domain:
  == domain 1  score: 54.3 bits;  conditional E-value: 2.2e-18
                   EEEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHH.HHHHESEEEEESSCSSSEHHHHHHHHHHCT..TTSEEEEEESS CS
  Response_reg   1 vlivdDdplvrellrqlleeegyeevaeaedgkealell.keekvdlillDinmpgmdGlellkeireed..pelpviiltah 80 
                   vl+vdD++++r++l+++ ++ g+ + ++a dg eale + ke+++dlillD+ mp + G e +k ir  +  ++++++++ta+
    EFC37856.1 455 VLVVDDNQVNRKVLQKMTNNLGF-NSQTACDGLEALETFkKEMNFDLILLDLLMPIICGKECCKLIRSIEkeRKCKIVAVTAN 536
                   8**********************.***************55667**********************98886688*******86 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.2   0.1   1.3e-11   7.9e-08       1      45 [.       4      74 ..       4      96 .. 0.68

  Alignments for each domain:
  == domain 1  score: 32.2 bits;  conditional E-value: 1.3e-11
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHC.........................T-HSSCHH...HHHHHH CS
       HisKA  1 slgrflagvaHELrtPLsailgnaeaLkre.......................gklteelke...yletie 45
                s+++f+++++HELr+PL+++l ++e+++ +                        +l  +lk+   +l++ie
  EFC37856.1  4 SKTKFISNLSHELRNPLHGLLVTVELMQLDmkkisetlqnlvglkiesfgkfvTRLQNDLKAqleLLHDIE 74
                799************************76666778888888866666666666444444444222444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (539 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1052  (0.0586759); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.46
# Mc/sec: 3502.76
//
Query:       EFC37857.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0038   16.1   0.1     0.0039   16.0   0.1    1.1  1  DUF2207   Predicted membrane protein (DUF2207)
  ------ inclusion threshold ------
        1.4    8.3   8.2        3.1    7.2   8.3    1.4  1  Jiraiya   Jiraiya


Domain annotation for each model (and alignments):
>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.1   4.3e-07    0.0039     369     434 ..      95     188 ..      42     190 .] 0.77

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 4.3e-07
     DUF2207 369 rgyfdkkgkkklkklsalglgliilglilillallllvll............................lvfllilllillliaiivlllfsrll 434
                  + +d +g++ + ++++++l+ iil++++++ +++  +++                            + f +++++++++++++++l++ +++
  EFC37857.1  95 GQVIDVEGNNARSSYHLAILISIILAMFCMVPLAFIPFSVvyfrfrsnptesprvyafsercrwiaigVLFSNVFMFLVAVMIVLIVLFSIGIF 188
                 5666777777777777777777777777766665555555788*************************66666666666666666666665555 PP

>> Jiraiya  Jiraiya
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   8.3   0.00034       3.1      83     129 ..     140     184 ..     107     186 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00034
     Jiraiya  83 kteq.gteRadkFLkdsravRivavglFflsipvfltalilytlllfe 129
                 ++++ ++ R+  F   s   R +a+g+ f  + +fl+a+++  ++lf+
  EFC37857.1 140 RSNPtESPRVYAF---SERCRWIAIGVLFSNVFMFLVAVMIVLIVLFS 184
                 3333344466666...667799**********************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1304  (0.0727313); expected 358.6 (0.02)
Passed bias filter:                      639  (0.0356406); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 1290.87
//
Query:       EFC37858.1  [L=277]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00033   20.6   9.6     0.0024   17.8   9.6    2.5  1  zf-RING_UBOX  RING-type zinc-finger
     0.0014   18.4  11.6     0.0014   18.4  11.6    2.6  3  zf-C3HC4_2    Zinc finger, C3HC4 type (RING finger)
     0.0019   18.1  10.6     0.0019   18.1  10.6    2.8  3  zf-RING_5     zinc-RING finger domain
     0.0028   17.5   7.9     0.0028   17.5   7.9    2.4  2  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
     0.0052   17.1  11.3     0.0052   17.1  11.3    2.3  2  zf-RING_2     Ring finger domain
  ------ inclusion threshold ------
       0.01   16.5   0.7       0.01   16.5   0.7    2.1  1  zf-TRAF       TRAF-type zinc finger
       0.02   15.0   8.7       0.02   15.0   8.7    2.7  2  zf-C3HC4_4    zinc finger of C3HC4-type, RING
      0.029   14.3  11.9      0.029   14.3  11.9    2.8  3  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
      0.096   13.1   0.2       0.35   11.3   0.0    2.0  2  BTB_2         BTB/POZ domain
       0.65    9.2   3.3          1    8.5   3.3    1.3  1  TMPIT         TMPIT-like protein
        0.9    9.0   3.7        1.2    8.7   3.7    1.1  1  Exonuc_VII_L  Exonuclease VII, large subunit
       0.91    8.3   5.2       0.16   10.7   1.3    1.7  2  TssC          Type VI secretion system, TssC, VipB
        2.4    8.1   9.9       0.66    9.9   6.1    2.0  2  zf-RING_6     zf-RING of BARD1-type protein
        4.9    7.3  15.0          2    8.5  12.3    1.8  2  zf-C3H2C3     Zinc-finger
        5.9    7.1  12.0          2    8.6   8.0    2.2  2  DUF1272       Protein of unknown function (DUF1272)
        6.5    6.7  10.4         44    4.0  10.4    2.5  1  zf-Nse        Zinc-finger of the MIZ type in Nse subunit


Domain annotation for each model (and alignments):
>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   9.6   2.2e-06    0.0024       1      26 [.      47      73 ..      47     109 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 2.2e-06
  zf-RING_UBOX  1 CpIClelftdPlv.l.pCGHtFCreClw 26
                  C+ICl +f dP +   +CG tFC +C++
    EFC37858.1 47 CSICLHPFVDP-IsHnSCGNTFCAKCIE 73
                  ***********.65558**********3 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4  11.6   1.3e-06    0.0014       2      40 .]      47      81 ..      46      81 .. 0.96
   2 ?   -1.5   0.8         2   2.3e+03      28      38 ..     116     129 ..     100     130 .. 0.47
   3 ?   -3.0   0.0       6.4   7.2e+03       9      19 ..     258     268 ..     256     268 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.3e-06
  zf-C3HC4_2  2 CpiCldmlkdpsvvtpCgHvfCqkCilrsLeekneCPlC 40
                C iCl  + dp+  + Cg +fC+kCi         CPlC
  EFC37858.1 47 CSICLHPFVDPISHNSCGNTFCAKCIENV----TVCPLC 81
                ****************************6....79**** PP

  == domain 2  score: -1.5 bits;  conditional E-value: 2
  zf-C3HC4_2  28 lr.sLeekn..eCP 38 
                 lr  L++++   CP
  EFC37858.1 116 LRgELKDHQekYCP 129
                 33333333322566 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 6.4
  zf-C3HC4_2   9 lkdpsvvtpCg 19 
                 + dp++ + C+
  EFC37858.1 258 FDDPIYFIDCN 268
                 78999999996 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1  10.6   1.7e-06    0.0019       2      43 ..      47      82 ..      46      83 .. 0.97
   2 ?    1.0   0.5      0.38   4.3e+02      33      43 ..      95     112 ..      88     113 .. 0.66
   3 ?   -2.9   0.0       6.1   6.9e+03      34      40 ..     123     129 ..     117     130 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.7e-06
   zf-RING_5  2 CnkCfeklskeekfyltsCgHifCekClkkllekeavCpiCr 43
                C++C  ++   +++   sCg +fC kC+ + +    vCp+C+
  EFC37858.1 47 CSICLHPF--VDPISHNSCGNTFCAKCIENVT----VCPLCN 82
                ********..**********************....*****7 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.38
   zf-RING_5  33 l.......ekeavCpiCr 43 
                 +       + +++C +C+
  EFC37858.1  95 KtirnmldKLKVKCGMCK 112
                 4444555677899****8 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 6.1
   zf-RING_5  34 ekeavCp 40 
                 ++e++Cp
  EFC37858.1 123 HQEKYCP 129
                 3589999 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   7.9   2.5e-06    0.0028       2      45 ..      44      83 ..      43      84 .. 0.88
   2 ?   -0.2   0.5      0.86   9.6e+02      35      45 ..      99     113 ..      88     118 .. 0.62

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 2.5e-06
                GSB-TTTSSSBS-.EEETTEEEEEE-HHHHHHHHHTT-B-TTT-- CS
  zf-C3HC4_3  2 deeCviClerprn.vvllpCgHlvlCeeCaekllkrkkkCpiCrr 45
                d +C+iCl+   + +    Cg + +C +C e++    + Cp+C++
  EFC37858.1 44 DLICSICLHPFVDpISHNSCGNT-FCAKCIENV----TVCPLCNE 83
                789*******999456678**99.*********....******96 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.86
                 H....TT-B-TTT-- CS
  zf-C3HC4_3  35 k....rkkkCpiCrr 45 
                 +     k kC +C+ 
  EFC37858.1  99 NmldkLKVKCGMCKN 113
                 244445678888875 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1  11.3   4.6e-06    0.0052       3      44 .]      47      82 ..      45      82 .. 0.81
   2 ?   -0.5   0.2       1.5   1.7e+03      21      27 ..     108     112 ..      86     130 .. 0.55

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 4.6e-06
   zf-RING_2  3 CpICleelssadsvlllpCgHvfhreClerwlrssstCPlCr 44
                C+ICl ++   d +    Cg +f+ +C+e+       CPlC+
  EFC37858.1 47 CSICLHPFV--DPISHNSCGNTFCAKCIEN----VTVCPLCN 82
                ********7..4555557*********977....346****5 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.5
   zf-RING_2  21 CgHvfhr 27 
                 Cg  +++
  EFC37858.1 108 CG--MCK 112
                 43..333 PP

>> zf-TRAF  TRAF-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   16.5   0.7   9.1e-06      0.01       8      38 ..     104     132 ..      99     151 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 9.1e-06
                 SEEE-TT--S-BEEETTTCCCCCCTTSTTS- CS
     zf-TRAF   8 apvpCpnecckkkilRkdlkdHlekdCkkae 38 
                  +v+C  + ck+++lR +lkdH ek+C+  e
  EFC37858.1 104 LKVKC--GMCKNIVLRGELKDHQEKYCPLHE 132
                 68999..78******************9766 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   8.7   1.8e-05      0.02       1      28 [.      47      75 ..      47      81 .. 0.90
   2 ?   -1.7   0.1         3   3.4e+03      16      25 ..     108     115 ..      99     130 .. 0.52

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.8e-05
  zf-C3HC4_4  1 CPiCldYLekPvsle.CGhsfClsCissl 28
                C iCl  + +P+s + CG +fC +Ci+++
  EFC37858.1 47 CSICLHPFVDPISHNsCGNTFCAKCIENV 75
                9************866**********986 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 3
  zf-C3HC4_4  16 CGhsfClsCi 25 
                 CG  +C + +
  EFC37858.1 108 CG--MCKNIV 115
                 43..344444 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3  11.9   2.6e-05     0.029       1      41 []      47      81 ..      47      81 .. 0.98
   2 ?    1.0   0.2      0.35   3.9e+02      26      41 .]      97     111 ..      93     111 .. 0.87
   3 ?   -0.3   0.7      0.93     1e+03      22      40 ..     108     130 ..     106     130 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.6e-05
                -TTT-S--SS-E.E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4  1 CpiCleeakepnelleCkHsfCskCirkilksrkkvkCPlC 41
                C+iCl+ +++p     C+ +fC kCi++++       CPlC
  EFC37858.1 47 CSICLHPFVDPISHNSCGNTFCAKCIENVTV------CPLC 81
                *****************************99......9999 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.35
                 HHHHHHCTSSB--TTT CS
    zf-C3HC4  26 irkilksrkkvkCPlC 41 
                 ir++l+ + kvkC +C
  EFC37858.1  97 IRNMLD-KLKVKCGMC 111
                 788888.999****99 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.93
                 -CHHHHHHHHC....TSSB--TT CS
    zf-C3HC4  22 CskCirkilks....rkkvkCPl 40 
                 C +C   +l+     +++++CPl
  EFC37858.1 108 CGMCKNIVLRGelkdHQEKYCPL 130
                 77776666665676677777986 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       3.9   4.3e+03      13      38 ..     158     182 ..     141     200 .. 0.61
   2 ?   11.3   0.0   0.00031      0.35       1      57 [.     212     276 ..     212     277 .] 0.76

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 3.9
                 EHHHHHTSTTSTTTSSGG....GGEE CS
       BTB_2  13 skstLsrkpdtlLgkllkteelddyd 38 
                  ++ L +  + +L++l+++  +d+++
  EFC37858.1 158 ENEQLLTVSKDRLASLEQQL-IDQFR 182
                 44444445555555555522.33333 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00031
                 EEEEETTEEEEEEHHHHH...TSTTSTTTSSGG.........GGEETTTTEEEE-S-HHHHHHHH CS
       BTB_2   1 vklnVgGtrfetskstLs...rkpdtlLgkllkte.....elddydeetneyffDRspklFetiL 57 
                 ++lnV Gt++ +s    +   + pd l++k+ + e     +  +++ ++  yf+D +p +F++iL
  EFC37858.1 212 IHLNVRGTIMTVSLGDFTsnqQEPDNLFKKMFNGEypcyqTPASKQFDDPIYFIDCNPLIFSHIL 276
                 679999999988875554111569*********998887434555556678*************9 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   3.3   0.00093         1       6     104 ..     129     228 ..     124     255 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00093
       TMPIT   6 elekefkeleeta.keykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelkerkkvlkevesllpkknglylklvlGn 103
                  l++ ++++ee + k  +++le++++lq++  + ++  k rl +l+++l +  ++++e  e++++e ++++  r+k  ++ + +  + +g+ + + lG+
  EFC37858.1 129 PLHEAYQQVEEFKsKLEREHLERMAALQTENEQLLTVSKDRLASLEQQLIDQFRKKEELLETRMNEFENQVLAREKLENSNKPIHLNVRGTIMTVSLGD 227
                 578999****98824557889**************************998877777899999********99998877666666666689888888886 PP

       TMPIT 104 v 104
                  
  EFC37858.1 228 F 228
                 5 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   3.7     0.001       1.2     161     227 ..     139     207 ..      86     243 .. 0.50

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.001
  Exonuc_VII_L 161 krlleekkqrleklasrlkspeellerkrqrldeleerleralkkqlkkkrerleelkerl.k.eklee 227
                   + + + ++++le++a   +++e+ll+ +++rl +le++l  + +k+ +  ++r++e+++++   ekle+
    EFC37858.1 139 EFKSKLEREHLERMAALQTENEQLLTVSKDRLASLEQQLIDQFRKKEELLETRMNEFENQVlArEKLEN 207
                   111122223333333222345555555555555555555554444444444444444433322233333 PP

>> TssC  Type VI secretion system, TssC, VipB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.93     1e+03     117     150 ..      10      43 ..       4      45 .. 0.82
   2 ?   10.7   1.3   0.00015      0.16      63     148 ..      92     177 ..      82     208 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.93
        TssC 117 dkvknvtivnaeldqlkdldntrfidavaeelkq 150
                 + + n +i  +++  +k+  + + +d+v++e+ +
  EFC37858.1  10 KLIANSSITSSNTPLIKEEKEEVLFDYVEKEIDE 43 
                 5578999999999999999999999999999875 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00015
        TssC  63 essesveelvekskekaeeaee.llkknlkkaveevreleksyrsvalfykntesdkvknvtivnaeldqlkdldntrfidavaeel 148
                  s+++++++++k k k+  +++ +l+ +lk   e+   l ++y++v+ f    e+++++ ++ + +e +ql  + + r    ++++l
  EFC37858.1  92 ASAKTIRNMLDKLKVKCGMCKNiVLRGELKDHQEKYCPLHEAYQQVEEFKSKLEREHLERMAALQTENEQLLTVSKDRLA-SLEQQL 177
                 67899************9998735788999999**************************************888776643.344444 PP

>> zf-RING_6  zf-RING of BARD1-type protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   6.1   0.00059      0.66       7      47 ..      44      82 ..      39      94 .. 0.88
   2 ?   -1.7   0.1       2.4   2.7e+03       5      17 ..     102     115 ..      98     130 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00059
   zf-RING_6  7 llrcsrctdilrepvclggcehifcsncisdcfgsgcpvcy 47
                 l cs c   + +p+    c   fc+ ci +   + cp+c 
  EFC37858.1 44 DLICSICLHPFVDPISHNSCGNTFCAKCIENV--TVCPLCN 82
                578**************************997..6799996 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 2.4
   zf-RING_6   5 ekl.lrcsrctdil 17 
                 +kl ++c  c +i+
  EFC37858.1 102 DKLkVKCGMCKNIV 115
                 55545788888774 PP

>> zf-C3H2C3  Zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  12.3    0.0018         2       1      35 []      47      82 ..      47      82 .. 0.96
   2 ?   -3.4   0.0       9.6   1.1e+04      27      33 ..     124     130 ..     123     130 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0018
   zf-C3H2C3  1 CdnCglkLdypfvaysCkHlvHakC.adeevCPkCk 35
                C +C  +   p+++ sC   + akC  + +vCP+C+
  EFC37858.1 47 CSICLHPFVDPISHNSCGNTFCAKCiENVTVCPLCN 82
                999*****9****************8899******8 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 9.6
   zf-C3H2C3  27 deevCPk 33 
                 +e  CP+
  EFC37858.1 124 QEKYCPL 130
                 7889996 PP

>> DUF1272  Protein of unknown function (DUF1272)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   8.0    0.0018         2      29      50 ..      65      85 ..      45      91 .. 0.80
   2 ?   -0.8   0.1       1.5   1.7e+03       3      15 ..     103     115 ..     100     124 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0018
     DUF1272 29 ctFCaeCaeevlenvCPncg.Ge 50
                 tFCa+C e+v   vCP c+ G+
  EFC37858.1 65 NTFCAKCIENV--TVCPLCNeGG 85
                6**********..******6355 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.5
     DUF1272   3 elrpnCecCdkdl 15 
                 +l+ +C +C++ +
  EFC37858.1 103 KLKVKCGMCKNIV 115
                 4788899997654 PP

>> zf-Nse  Zinc-finger of the MIZ type in Nse subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0  10.4     0.039        44      11      53 ..      44      80 ..      36     132 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.039
                XSB-TTTSSB-SSEEEESSS--EEEHHHHHHHCTTTS-EE-SC CS
      zf-Nse 11 slkCPltlqpfeePvtskkCpHvFEreaIlelikrkktvkCPv 53
                +l C + l+pf++P+    C  +F  + I+++        CP+
  EFC37858.1 44 DLICSICLHPFVDPISHNSCGNTFCAKCIENVT------VCPL 80
                789*********************999998776......3443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1637  (0.0913046); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.61u 0.27s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 1737.18
//
Query:       EFC37859.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.023   15.0   1.4      0.023   15.0   1.4    2.3  2  M11L      Apoptosis regulator M11L like


Domain annotation for each model (and alignments):
>> M11L  Apoptosis regulator M11L like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.2     0.045     8e+02     113     158 ..     122     166 ..      61     180 .. 0.65
   2 ?   15.0   1.4   1.3e-06     0.023       9      62 ..     252     303 ..     240     314 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.045
                 HHHHTTHHHHHHHHTXXXXXXXXXXXXXXXXXXXXXXX......XXXXX CS
        M11L 113 dkIseeendiinfidrekkynvteyvkrsylkllgitaivv...Ykilk 158
                   Is+++ +++++i+  k++   ++     l+ + i  ++    Y+i+k
  EFC37859.1 122 LTISQNQYNLVELITYLKEKYKHSF----ILRNIEIHKLIDrepYEIIK 166
                 3466666666666554432222222....23334444444334444444 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.3e-06
                 HHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHHTHHHHHHHHHHHSSST--HHH CS
        M11L   9 nkkrlddlkrkletkerslldkikksCekinndYakdlnslydileveditvyd 62 
                 +k++l+   ++l++ker++ +k++   ++i n Y+ ++n++ d l+  + t+ d
  EFC37859.1 252 EKENLVLTVNSLKKKERDMQCKLQDRKDSISNFYKDQMNIIRDKLD--SQTKLD 303
                 56667777899********************************998..555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1796  (0.100173); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.51
# Mc/sec: 2131.54
//
Query:       EFC37860.1  [L=626]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00068   19.7  16.0     0.0012   18.9  16.0    1.4  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
       0.14   12.2   0.0       0.28   11.3   0.0    1.5  1  PAS_8     PAS domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9  16.0   1.3e-07    0.0012       1      37 [.      43      78 ..      43      81 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 1.3e-07
                SS-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCC CS
     Zn_clus  1 haCdnCrkkKvKCdakkPaCsnCkklnleCtfysess 37
                +aC++C+k +  C+ k+P C++C++l+leC + + ++
  EFC37860.1 43 KACEHCKKSHACCEDKRP-CKRCATLGLECFDVPSKK 78
                59****************.***********9666655 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   3.1e-05      0.28       2      47 ..     521     569 ..     520     583 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3.1e-05
       PAS_8   2 rlralfesspdgiav..vd.lgdrivdvNqaalellGys.adlkgellgq 47 
                 +++++++    +i+v  +d +g+ ++ +N +a e lGy+ a+l   ++++
  EFC37860.1 521 YIKGILNLCGAPILVysLDfGGR-LLLWNSKANETLGYEtAPLGMLKFDD 569
                 7889999999999*855566665.*************9877655444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (626 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 3853.94
//
Query:       EFC37861.1  [L=440]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-20   73.8   4.4      0.012   16.2   0.0    8.4  7  RCC1      Regulator of chromosome condensation (RCC1) repeat
    3.6e-18   64.9  18.3    8.8e-06   25.4   0.0    7.2  7  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.1   1.9e-05      0.17       3      50 .]       9      61 ..       7      61 .. 0.71
   2 !    8.1   0.0   0.00047       4.2      23      47 ..     108     134 ..      64     137 .. 0.68
   3 ?   -1.5   0.0      0.47   4.2e+03      26      49 ..     162     185 ..     146     186 .. 0.62
   4 !    4.7   0.0    0.0052        47      24      48 ..     219     249 ..     204     251 .. 0.70
   5 !   16.2   0.0   1.4e-06     0.012       3      50 .]     256     305 ..     254     305 .. 0.83
   6 !   14.3   1.5   5.3e-06     0.048       4      49 ..     310     353 ..     308     354 .. 0.78
   7 !    7.5   0.0   0.00072       6.5       3      48 ..     360     405 ..     358     407 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.9e-05
                EEEEEE--GGGTTSSSS-..--EEEEEE-.GGGTTS.....-EEEEEEETTEEEEE CS
        RCC1  3 rVysWGrndyGqLGlgtt..esvlvPtkv.eglsgn.....rvvkvacGddhtval 50
                +Vys G n+yGqL  +++  +++     + +gl+ +      ++++ +Gdd+t++l
  EFC37861.1  9 DVYSTGDNSYGQLFGKPSiiDNE---FVInNGLKTTlknekFITQIGAGDDFTAFL 61
                7************6666667555...2222444433555569999********986 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00047
                 EEEEEE-GGGTTS..-EEEEEEETTEE CS
        RCC1  23 vlvPtkveglsgn..rvvkvacGddht 47 
                 v+ Pt v++ + +   +++ +cG++h 
  EFC37861.1 108 VDEPTVVNTKKFKteTITHLSCGSNHI 134
                 255999977666677***********6 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.47
                 EEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1  26 PtkveglsgnrvvkvacGddhtva 49 
                 P++   +++n ++ v +G +++v+
  EFC37861.1 162 PKEYLKSDNNFISMVGSGLNFSVF 185
                 544444444566678888888887 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.0052
                 EEEEE-......GGGTTS-EEEEEEETTEEE CS
        RCC1  24 lvPtkv......eglsgnrvvkvacGddhtv 48 
                  +P+k       +g++++ +++ acG +h +
  EFC37861.1 219 FKPQKTmvymkkTGFEEDGIIDLACGKNHFI 249
                 5576654444546777779**********65 PP

  == domain 5  score: 16.2 bits;  conditional E-value: 1.4e-06
                 EEEEEE--GGGTTSSSS-...--EEEEEE-GGGTTS.-EEEEEEETTEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt...esvlvPtkveglsgn.rvvkvacGddhtval 50 
                 ++y+ G+n +GqLG   +   e++   +k+++l+   r++++ cG+ +++ +
  EFC37861.1 256 EIYGMGSNFEGQLGETAEnkyEDR--FVKIKLLEPSlRISSIECGALFSAYI 305
                 69*************777667444..37888888778*********999865 PP

  == domain 6  score: 14.3 bits;  conditional E-value: 5.3e-06
                 EEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtva 49 
                 ++  G+n+yGqLGlg + +    t+v++    +  k++cG +h+++
  EFC37861.1 310 LFMSGSNQYGQLGLGYKTKFMGFTEVMTIY--EDFKISCGRNHSIV 353
                 7888************97774445555555..77899999999975 PP

  == domain 7  score: 7.5 bits;  conditional E-value: 0.00072
                 EEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtv 48 
                 +V+  G+n + qLG+gt  +v + +++ +  ++++ ++ cG   ++
  EFC37861.1 360 QVLVSGFNGEAQLGIGTGPNVRTFKLIDMKFDKKIAHILCGRASSI 405
                 68888**********8885554456665555559999999987775 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.2   1.7e-05      0.15      19      30 .]       9      20 ..       7      20 .. 0.94
   2 !   12.6   0.1   9.7e-06     0.087       1      27 [.      48      74 ..      48      76 .. 0.93
   3 !    4.5   0.7    0.0036        33       1      19 [.     124     143 ..     124     152 .. 0.63
   4 ?   -0.1   0.1       0.1   8.9e+02       4      22 ..     176     194 ..     172     196 .. 0.78
   5 !   25.4   0.0   9.8e-10   8.8e-06       1      30 []     238     267 ..     238     267 .. 0.98
   6 !    3.4   0.0    0.0079        71      18      30 .]     308     320 ..     292     320 .. 0.81
   7 !   14.0   0.1   3.6e-06     0.032       3      27 ..     343     368 ..     343     371 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.7e-05
      RCC1_2 19 eVlcWGsNsdGQ 30
                +V+++G+Ns+GQ
  EFC37861.1  9 DVYSTGDNSYGQ 20
                7**********9 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 9.7e-06
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNs 27
                ++++ aGd+++ +Lt d+ ++  G N 
  EFC37861.1 48 ITQIGAGDDFTAFLTHDNSLFVAGYNA 74
                689*********************995 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.0036
      RCC1_2   1 VksvsaGdyH.scaLtedGe 19 
                 ++++s+G++H s++  ++++
  EFC37861.1 124 ITHLSCGSNHiSVVTNRSNI 143
                 5789******6665555554 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.1
      RCC1_2   4 vsaGdyHscaLtedGeVlc 22 
                 v +G ++s+++++  +V+ 
  EFC37861.1 176 VGSGLNFSVFVVNLRDVYV 194
                 559******9999777776 PP

  == domain 5  score: 25.4 bits;  conditional E-value: 9.8e-10
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++++G +H+++Lt+ +e+++ GsN  GQ
  EFC37861.1 238 IIDLACGKNHFIILTDQNEIYGMGSNFEGQ 267
                 799**************************9 PP

  == domain 6  score: 3.4 bits;  conditional E-value: 0.0079
      RCC1_2  18 GeVlcWGsNsdGQ 30 
                 ++++  GsN +GQ
  EFC37861.1 308 NKLFMSGSNQYGQ 320
                 579999******9 PP

  == domain 7  score: 14.0 bits;  conditional E-value: 3.6e-06
      RCC1_2   3 svsaGdyHsca.LtedGeVlcWGsNs 27 
                 ++s+G++Hs++ L+ ++ Vl  G N+
  EFC37861.1 343 KISCGRNHSIVhLVKSNQVLVSGFNG 368
                 69*******************99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (440 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       381  (0.0212505); expected 358.6 (0.02)
Passed bias filter:                      258  (0.0143901); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2890.23
//
Query:       EFC37862.1  [L=590]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.016   15.1   0.9       0.14   12.1   0.5    2.4  2  PB1       PB1 domain


Domain annotation for each model (and alignments):
>> PB1  PB1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.5     8e-06      0.14       5      68 ..       9      73 ..       5      83 .. 0.89
   2 ?    0.5   0.0     0.033     6e+02      10      51 ..     133     173 ..     127     175 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 8e-06
                EEEETTEEEEEEEEGSSS-HHHHHHHHHHHHTST.CCSEEEEEEETTS.SEEEESSHHHHHHHHHH CS
         PB1  5 KlrygggirrelsvssnisfeeLrakvekrfkls.dedvklkYpdedg.dlVtitsDeDLeealee 68
                 +++++  +  + vs+++s ++L++ ++++++l  +e++ + Y d  +  ++ +++D+ +++++++
  EFC37862.1  9 VVHFNDVNHL-ITVSKETSHQDLISAIRDELALLpNEKIEVYYLDPKLeREIVLKNDSYVKRFFKH 73
                5677777777.*************************************99*******988888765 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.033
                 TEEEEEEEEGSSS-HHHHHHHHHHHHTSTCCSEEEEEEETTS CS
         PB1  10 ggirrelsvssnisfeeLrakvekrfklsdedvklkYpdedg 51 
                 gg+++ ++ s  + +++ ++  +++++++++++kl+  +ed+
  EFC37862.1 133 GGKHK-IFNSTATLWKDIFDYAKSKLEITSSSFKLQVMNEDN 173
                 56666.89999999**********************999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (590 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1680  (0.0937029); expected 358.6 (0.02)
Passed bias filter:                      554  (0.0308997); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.50
# Mc/sec: 3523.78
//
Query:       EFC37863.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.6e-16   58.3   0.0    1.4e-15   57.5   0.0    1.3  1  GST_N_3   Glutathione S-transferase, N-terminal domain
    9.3e-15   54.7   0.0    1.8e-14   53.7   0.0    1.5  1  GST_N_2   Glutathione S-transferase, N-terminal domain
    1.4e-14   54.2   0.0    2.4e-14   53.4   0.0    1.4  1  GST_N     Glutathione S-transferase, N-terminal domain
    8.9e-14   51.5   0.0    1.2e-13   51.1   0.0    1.3  1  GST_C     Glutathione S-transferase, C-terminal domain
    1.1e-06   28.5   0.0    2.3e-06   27.5   0.0    1.5  1  GST_C_2   Glutathione S-transferase, C-terminal domain
    3.5e-06   27.1   0.0    6.2e-06   26.3   0.0    1.4  1  GST_C_3   Glutathione S-transferase, C-terminal domain


Domain annotation for each model (and alignments):
>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.5   0.0   4.6e-19   1.4e-15      10      73 ..       8      74 ..       7      76 .. 0.94

  Alignments for each domain:
  == domain 1  score: 57.5 bits;  conditional E-value: 4.6e-19
                HHHHHHHHHHHT--EE..EE---TTTT.HHHHHHH-TT--SSEEETTS-EEESHHHHHHHHHHHH-G CS
     GST_N_3 10 arrvrlaLnekglpve..vvevtpgeh.deellaknplgkvPvLeddgealtdSlaIidyLeelypg 73
                ++rv  +L+ekgl++e  vv++++geh ++++l+k p g +PvL ddg  +++S+aI++yLe ++ g
  EFC37863.1  8 VQRVLTTLKEKGLEHEliVVDLSKGEHkSPSFLEKQPFGVIPVLDDDGFLIYESRAICRYLEAKHKG 74
                69**************5559999***99***********************************9986 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.7   0.0   6.1e-18   1.8e-14       5      69 ..       8      70 ..       6      71 .. 0.95

  Alignments for each domain:
  == domain 1  score: 53.7 bits;  conditional E-value: 6.1e-18
                HHHHHHHHHHCT--EEEEEEH...-TTSHHHHHHHHCTTTSSSEEE-CTTEEEESHHHHHHHHHH CS
     GST_N_2  5 ahRvlialalkglediisvvvlepkgfekseefprlnprgtVPvLwdkdgqvineSseIlrylet 69
                ++Rvl +l++kgle++++vv+l  kg++ks+ f++  p+g +PvL d dg  i+eS++I+ryle+
  EFC37863.1  8 VQRVLTTLKEKGLEHELIVVDL-SKGEHKSPSFLEKQPFGVIPVLDD-DGFLIYESRAICRYLEA 70
                69******************66.7**********************8.9**************96 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.4   0.0   8.1e-18   2.4e-14      13      75 ..       7      69 ..       2      70 .. 0.94

  Alignments for each domain:
  == domain 1  score: 53.4 bits;  conditional E-value: 8.1e-18
                THHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTTS-SSEEEETTEEEESHHHHHHHHH CS
       GST_N 13 rahrirlllaakgveyevvpldfeageekspellklnplgkvPaLedngkkltESraIleYia 75
                ++ r++ +l++kg+e e + +d+++ge+ksp +l ++p+g +P+L d+g+ + ESraI++Y++
  EFC37863.1  7 LVQRVLTTLKEKGLEHELIVVDLSKGEHKSPSFLEKQPFGVIPVLDDDGFLIYESRAICRYLE 69
                577999*******************************************************96 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.1   0.0   4.1e-17   1.2e-13      19      93 .]     123     199 ..      79     199 .. 0.90

  Alignments for each domain:
  == domain 1  score: 51.1 bits;  conditional E-value: 4.1e-17
                 HHHHHHHHHHHHHHHHHHHHHHHHHTSSSSSTTSSCHHHHHHHHHHHHHHHHTTTTT..TTTSHHHHHHHHHHHTSH CS
       GST_C  19 kkeelvdealekvaevlsaleeelkkqdylvGdkltlADialvpilnwlqrlglafg..qekfpnlkawlerimarp 93 
                 ++ + v+++ +k++  l+a+e+ l+kq ++ G+++tlAD++++p    l+ + +++g   ++ p++kaw+e+i++rp
  EFC37863.1 123 TDDARVKQLTDKLNQHLDAYEKILSKQEFIGGNQFTLADLYHLPYGSLLFAPPVGLGnlITDRPHVKAWWEKISSRP 199
                 5667899999***********************************999999999999999****************9 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.0   7.6e-10   2.3e-06       2      66 ..     126     191 ..     125     194 .. 0.93

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 7.6e-10
                 HHHCHHHHHCCHCHHHCTTT---SS.CTTCS--HHHHHHHHHHHHHHHHHHS-.---TT-HHHHHH CS
     GST_C_2   2 aaveraleqldaaldaleahLadspflfGdqptlaDialapflvrlraagpgf.direaypnlraW 66 
                 a v+++ ++l ++lda e++L ++ f++G+q+tlaD    p    l a++ g+ ++  + p+++aW
  EFC37863.1 126 ARVKQLTDKLNQHLDAYEKILSKQEFIGGNQFTLADLYHLPYGSLLFAPPVGLgNLITDRPHVKAW 191
                 78999999**************************************99999998788999999999 PP

>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.0   2.1e-09   6.2e-06      21      93 ..     127     202 ..     109     205 .. 0.80

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 2.1e-09
                 HHHHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHH.....TCC.CC-HHHHHHHHHHHTSHHHH CS
     GST_C_3  21 kkefleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleea.....eal.kkfpklkalyervearpkik 93 
                 + + l+++l+++l+++ek+l+  +++++ g+++T+ADl  + + + l +a     ++l ++ p++ka++e++++rp+ k
  EFC37863.1 127 RVKQLTDKLNQHLDAYEKILS--KQEFIGGNQFTLADLYHLPYGSLL-FAppvglGNLiTDRPHVKAWWEKISSRPSWK 202
                 55667899*************..999************888755444.44488874445999**************865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       590  (0.0329076); expected 358.6 (0.02)
Passed bias filter:                      584  (0.0325729); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.51u 0.32s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 1238.38
//
Query:       EFC37864.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.5e-69  232.7   0.0    4.5e-69  232.3   0.0    1.1  1  polyprenyl_synt  Polyprenyl synthetase
     0.0017   18.0   0.1     0.0031   17.1   0.1    1.4  1  HEPPP_synt_1     Heptaprenyl diphosphate synthase (HEPPP synt


Domain annotation for each model (and alignments):
>> polyprenyl_synt  Polyprenyl synthetase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  232.3   0.0     5e-73   4.5e-69       2     253 ..     138     386 ..     137     389 .. 0.95

  Alignments for each domain:
  == domain 1  score: 232.3 bits;  conditional E-value: 5e-73
                      HHHHHHHHHHHHSSS--HHHHHHHHHHHHHSCG......HHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-SEETTEE-HHHCTCHHHHHHHHHH CS
  polyprenyl_synt   2 elleealeylveagGKrlRpllvllaaealkee......eeelekaavlawivellhaasLvhDDimDdsetRRGqpcahrlvGnklAindgdf 89 
                      + l++a++y+++ +GK +Rp+lvl++ +a++e+      e+ ++k+++la+ +el+h+asL+hDDi+Dd++tRRG p+ +++vGnk+A+++gdf
       EFC37864.1 138 PVLDAAAKYFFNTPGKLFRPMLVLMTGRAVNEQteisdlETIMRKQRKLAETTELIHVASLIHDDIVDDADTRRGIPALNKNVGNKVAVLAGDF 231
                      57899**************************555677776899*************************************************** PP

                      HHHHHHHHHHHHHSTTHHHHHHHHHHHHHHHHHHHHHHHHTTTTTCCC.SHHHHHHHHHHHTHHHCHHHHHHHHHHTTHHH.HHHHHHHHHHHH CS
  polyprenyl_synt  90 llarafellaklfekslellelfsevllqtveGqlldleeekdddlskfsleeyleivkyKTaylfalpvalaallagasd.eelealkdigle 182
                      ll+ra++ la++  +++e ++l+s+v+ +++ G++l++    + +l+   ++ y++ +  KT++l+a+++++ a+l+g ++ e ++a++++g++
       EFC37864.1 232 LLGRASINLARI--GNIESIDLISTVIEHLAYGEVLQMAG--KGKLD---FDYYMKTIFFKTSSLIANSCKASAVLSGSTNrELIDAAYTFGKH 318
                      ************..************************43..59999...****************************8885778********* PP

                      HHHHHHHHHHHHHHHS-HHHHSS-T.SHHHHTT---HHHHHHHHCT-HHHHHHHHHHTTSSHHHHHHHHHHH CS
  polyprenyl_synt 183 lGlaFQiqDDylDlfgdpevlgKpa.gtDiqegkctlpilkalelaspeqrkvlkeilgkkaekeedvkeal 253
                      +G+a+Q+ DD lD+++++++lgKp  g+D++ g  t pi++a + a pe   ++k i+ +k++ e+d++ a 
       EFC37864.1 319 VGIAYQLTDDSLDFTQSQNDLGKPSqGADMKLGLTTCPIIFAAQ-AFPE---QMKPIIDRKFSGEGDIEMAR 386
                      ************************99******************.9999...69***********9998775 PP

>> HEPPP_synt_1  Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.1   3.5e-07    0.0031      29     105 ..     177     258 ..     169     298 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3.5e-07
  HEPPP_synt_1  29 eltekekeeyiltamlvqiAldtHdkvsek.keeeeeekkn....rqLtVLAGdyYSglYYklLaevkdielirllaeaike 105
                   e   +++++++ t+ l+++A  +Hd + +  ++++     n     +  VLAGd+  g     La++++ie i l+++ i  
    EFC37864.1 177 ETIMRKQRKLAETTELIHVASLIHDDIVDDaDTRRGIPALNknvgNKVAVLAGDFLLGRASINLARIGNIESIDLISTVIEH 258
                   555678889999*************998873444444444400225789*************************99998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       392  (0.021864); expected 358.6 (0.02)
Passed bias filter:                      304  (0.0169558); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2860.91
//
Query:       EFC37865.1  [L=974]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.8e-18   65.4   0.3    1.4e-17   63.9   0.3    1.9  1  VIT       Vault protein inter-alpha-trypsin domain
    3.5e-08   33.6   0.2    9.5e-08   32.2   0.2    1.8  1  DUF2135   Uncharacterized protein conserved in bacteria (DUF2
  ------ inclusion threshold ------
      0.017   15.3   0.0      0.033   14.3   0.0    1.4  1  TPR_9     Tetratricopeptide repeat
      0.034   14.5   0.0      0.077   13.3   0.0    1.6  1  TPR_12    Tetratricopeptide repeat
      0.045   13.4   2.9       0.12   12.0   2.9    1.7  1  YkyA      Putative cell-wall binding lipoprotein
      0.081   13.8   0.1       0.28   12.1   0.0    2.0  2  TPR_14    Tetratricopeptide repeat
       0.09   12.7   0.1        6.5    6.8   0.0    2.7  2  TPR_10    Tetratricopeptide repeat
       0.12   13.2   0.2       0.37   11.7   0.2    1.8  1  CTD_bind  RNA polymerase II-binding domain.
       0.16   11.9   0.0       0.35   10.8   0.0    1.6  1  TPR_1     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> VIT  Vault protein inter-alpha-trypsin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.9   0.3   6.8e-21   1.4e-17      20     111 .]       4      93 ..       1      93 [. 0.92

  Alignments for each domain:
  == domain 1  score: 63.9 bits;  conditional E-value: 6.8e-21
         VIT  20 tqtfvNpsseakeakYvfplpegaavsgfemeiggkvikgevkekeearkeyeeavaqgktaglleqe.epdvftvsvgnippgeevtveltY 111
                 + t++N+s   +e++ v+p+pe+a+ +g++me++gk i ++  eke+a++++e  v++g++++++e+  +++ f+++++++p +++ t++++Y
  EFC37865.1   4 RNTIENRS---IEGELVLPMPETATMTGYAMEVDGKLIDAVPVEKEKAKEVFESEVRAGNKVSMVEKVaQSNCFRTRIYPLPYNQDKTIQVKY 93 
                 33444555...9********************************************************99*********************99 PP

>> DUF2135  Uncharacterized protein conserved in bacteria (DUF2135)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.2   0.2   4.7e-11   9.5e-08       1      52 []     912     959 ..     912     959 .. 0.97

  Alignments for each domain:
  == domain 1  score: 32.2 bits;  conditional E-value: 4.7e-11
     DUF2135   1 plkGkYkVyVNYygggsenrsqtetalttlrltliteEGtpnekretfevpl 52 
                 ++kG Yk   NY+     n+sq+ t+ tt+  t++t++  pne+r++ +++l
  EFC37865.1 912 AQKGAYKATTNYFS----NHSQSLTGGTTILCTFFTNYMRPNEQRQMSTIRL 959
                 79************....99999**************************997 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   1.7e-05     0.033       6      54 ..     760     808 ..     756     820 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.7e-05
       TPR_9   6 ireedweralavverllllaPddpeerrdRGlllaqlGclsaAladLea 54 
                  ++e+ e a +v er+  ++  +p+ +rd +l+ +++G  ++A++ +++
  EFC37865.1 760 DQAEELELAEWVFERVKSINGFEPQSYRDLALVKERMGKHEEAMELFNR 808
                 58999**************************************987765 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   3.9e-05     0.077      46      71 ..     784     809 ..     772     810 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3.9e-05
      TPR_12  46 ttlrnLgrlyralgryeeAlelleea 71 
                 +++r+L+ + +++g++eeA el++++
  EFC37865.1 784 QSYRDLALVKERMGKHEEAMELFNRV 809
                 689********************997 PP

>> YkyA  Putative cell-wall binding lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   2.9   6.2e-05      0.12      75     119 ..     521     565 ..     470     579 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 6.2e-05
        YkyA  75 esieeakeefekikeeieeiedeelkkeaeelieameeryeaydk 119
                 + + e +++f ++k++ +e +d++ k+++e  i+ ++er + +++
  EFC37865.1 521 KTLTEVYKQFMQVKTSAQEAKDKQEKEKLERIISMWKERVNWHKT 565
                 678999*********************************999986 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1         9   1.8e+04      10      26 ..     758     774 ..     750     776 .. 0.68
   2 ?   12.1   0.0   0.00014      0.28       2      28 ..     784     810 ..     783     818 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 9
      TPR_14  10 allalGdpdeAiallrr 26 
                  l ++++++ A+ +++r
  EFC37865.1 758 RLDQAEELELAEWVFER 774
                 45677788888888887 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 0.00014
      TPR_14   2 eallalaeallalGdpdeAiallrral 28 
                 + +++la + ++ G+++eA++l++r++
  EFC37865.1 784 QSYRDLALVKERMGKHEEAMELFNRVI 810
                 6799*********************97 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.061   1.2e+02      14      36 ..     539     560 ..     537     567 .. 0.85
   2 ?    6.8   0.0    0.0033       6.5       4      29 ..     785     810 ..     784     811 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.061
      TPR_10  14 qrgrydeAealleealairrrll 36 
                 + ++ +e e+l e+ ++++++ +
  EFC37865.1 539 EAKDKQEKEKL-ERIISMWKERV 560
                 56899******.********976 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0033
      TPR_10   4 slnNLanalrqrgrydeAealleeal 29 
                 s+ +La +  ++g+++eA++l+ +++
  EFC37865.1 785 SYRDLALVKERMGKHEEAMELFNRVI 810
                 7899*****************97775 PP

>> CTD_bind  RNA polymerase II-binding domain.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.2   0.00018      0.37      39      60 ..     537     559 ..     515     560 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00018
    CTD_bind  39 yk.kapekikkklkrllniWeer 60 
                 ++  ++++ k+kl+r+++ W+er
  EFC37865.1 537 AQeAKDKQEKEKLERIISMWKER 559
                 224567999*************9 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00018      0.35       3      28 ..     785     810 ..     783     811 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00018
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekAL 28 
                 ++  l+++  ++gk++eA e +++++
  EFC37865.1 785 SYRDLALVKERMGKHEEAMELFNRVI 810
                 678899999**************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (974 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1353  (0.0754643); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.89u 0.31s 00:00:01.20 Elapsed: 00:00:00.53
# Mc/sec: 5514.79
//
Query:       EFC37866.1  [L=308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.4e-35  118.8   8.0    2.2e-06   27.4   0.1    6.7  6  NHL             NHL repeat
    9.3e-08   32.3   0.0         15    6.0   0.0    5.1  5  Linker_histone  linker histone H1 and H5 family
    0.00039   20.5   0.0         32    4.8   0.0    4.7  5  TGT_C2          Patch-forming domain C2 of tRNA-guanine trans
    0.00041   21.0   1.1         79    4.1   0.0    4.7  5  MJ1316          MJ1316 RNA cyclic group end recognition domai
     0.0026   17.9   0.0        3.1    7.8   0.0    4.2  2  ParBc_2         Putative ParB-like nuclease
     0.0059   16.1   0.0       0.66    9.4   0.0    2.8  3  MHC_I_3         MHC-I family domain
  ------ inclusion threshold ------
      0.011   15.2  33.0        1.7    8.3   0.3    7.9  9  Plasmo_rep      Plasmodium repeat family
      0.049   14.3   1.8         64    4.3   0.0    4.3  5  potato_inhibit  Potato inhibitor I family
      0.066   13.1   1.7         25    4.8   0.1    3.6  4  DUF4792         Domain of unknown function (DUF4792)
        0.1   12.5   5.0         25    4.7   0.0    4.2  5  NPH-II          RNA helicase NPH-II
       0.39    9.7   6.8         11    4.9   0.2    3.4  4  Coatomer_WDAD   Coatomer WD associated region
        0.7    9.4   2.8         96    2.4   0.0    3.7  5  Sua5_yciO_yrdC  Telomere recombination
        3.2    8.2  12.4         94    3.5   0.1    5.0  5  YdfZ            YdfZ protein


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.1     9e-09   1.2e-05       3      27 ..      12      36 ..      12      37 .. 0.92
   2 !   21.6   0.0   1.1e-07   0.00015       1      27 [.      66      92 ..      66      93 .. 0.93
   3 !   27.4   0.1   1.6e-09   2.2e-06       1      27 [.     122     148 ..     122     149 .. 0.94
   4 !   21.6   0.0   1.1e-07   0.00015       1      27 [.     178     204 ..     178     205 .. 0.93
   5 !   12.8   0.0     7e-05     0.097       1      27 [.     234     260 ..     234     261 .. 0.94
   6 !    9.5   0.0   0.00076         1       1      19 [.     290     308 .]     290     308 .] 0.95

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 9e-09
                SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrvqv 27
                +P++v v+sn+++y+aD++nhr+++
  EFC37866.1 12 NPSSVFVSSNNEVYIADFCNHRIRK 36
                589999*****************97 PP

  == domain 2  score: 21.6 bits;  conditional E-value: 1.1e-07
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                fnyP +v v+s +++y++D+ nhr+++
  EFC37866.1 66 FNYPCSVFVSSKNEVYITDYSNHRIRK 92
                89999999*****************97 PP

  == domain 3  score: 27.4 bits;  conditional E-value: 1.6e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P++v v+sn+++y+aD++nhr+++
  EFC37866.1 122 LYNPSSVFVSSNNEVYIADFCNHRIRK 148
                 689**********************97 PP

  == domain 4  score: 21.6 bits;  conditional E-value: 1.1e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 fnyP +v v+s +++y++D+ nhr+++
  EFC37866.1 178 FNYPCSVFVSSKNEVYITDYSNHRIRK 204
                 89999999*****************97 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 7e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P++v v+sn+++y +D +n+r+++
  EFC37866.1 234 LYNPSSVFVSSNNEVYFTDQHNNRIRK 260
                 689**********************87 PP

  == domain 6  score: 9.5 bits;  conditional E-value: 0.00076
                 BSSEEEEEEETTTEEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaD 19 
                 +++P++v v+sn+++y++D
  EFC37866.1 290 LYNPNSVFVSSNNEVYITD 308
                 689***************9 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0     0.011        15      33      67 ..      21      51 ..      15      57 .. 0.75
   2 ?    4.4   0.0     0.036        50      41      69 ..      81     109 ..      67     113 .. 0.77
   3 ?    6.0   0.0     0.011        15      33      67 ..     133     163 ..     127     169 .. 0.75
   4 ?    4.4   0.0     0.036        50      41      69 ..     193     221 ..     179     225 .. 0.77
   5 ?    4.6   0.0      0.03        41      33      67 ..     245     275 ..     239     281 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.011
  Linker_histone 33 kykvvdvskfksllkkalkkgvekgelvqpkgkGa 67
                    +++v     ++ ++++ ++k +e+g +v + g+G 
      EFC37866.1 21 NNEV----YIADFCNHRIRKILENGNIVTIAGNGN 51
                    4443....557789****************99664 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.036
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGasG 69 
                      ++ + ++ ++k +e+g ++ + g+G+ G
      EFC37866.1  81 YITDYSNHRIRKILENGNIITIAGNGTVG 109
                     456778999*************9977654 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.011
  Linker_histone  33 kykvvdvskfksllkkalkkgvekgelvqpkgkGa 67 
                     +++v     ++ ++++ ++k +e+g +v + g+G 
      EFC37866.1 133 NNEV----YIADFCNHRIRKILENGNIVTIAGNGN 163
                     4443....557789****************99664 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.036
  Linker_histone  41 kfksllkkalkkgvekgelvqpkgkGasG 69 
                      ++ + ++ ++k +e+g ++ + g+G+ G
      EFC37866.1 193 YITDYSNHRIRKILENGNIITIAGNGTVG 221
                     456778999*************9977654 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.03
  Linker_histone  33 kykvvdvskfksllkkalkkgvekgelvqpkgkGa 67 
                     +++      f+ + ++ ++k +e+g ++ + g+G 
      EFC37866.1 245 NNE----VYFTDQHNNRIRKILENGNIITIAGNGN 275
                     443....46788999***************99664 PP

>> TGT_C2  Patch-forming domain C2 of tRNA-guanine transglycosylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.61   8.4e+02      32      46 ..      32      45 ..      20      56 .. 0.76
   2 ?    4.8   0.0     0.023        32      23      56 ..      79     110 ..      64     115 .. 0.76
   3 ?    0.1   0.0      0.65   8.9e+02      32      46 ..     144     157 ..     135     168 .. 0.75
   4 ?    4.8   0.0     0.023        32      23      56 ..     191     222 ..     176     227 .. 0.76
   5 ?    2.7   0.0       0.1   1.4e+02      26      45 ..     250     269 ..     239     279 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.61
      TGT_C2 32 grirqvlvdgerlat 46
                 rir++l +g+ + t
  EFC37866.1 32 HRIRKILENGNIV-T 45
                69****9998754.4 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.023
      TGT_C2  23 dvtitrsatgrirqvlvdgerlatlraqdgrltL 56 
                 +v it  +  rir++l +g+ +    a +g+  +
  EFC37866.1  79 EVYITDYSNHRIRKILENGNIITI--AGNGTVGF 110
                 467776799********9987654..67776655 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.65
      TGT_C2  32 grirqvlvdgerlat 46 
                  rir++l +g+ + t
  EFC37866.1 144 HRIRKILENGNIV-T 157
                 69****9998754.4 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.023
      TGT_C2  23 dvtitrsatgrirqvlvdgerlatlraqdgrltL 56 
                 +v it  +  rir++l +g+ +    a +g+  +
  EFC37866.1 191 EVYITDYSNHRIRKILENGNIITI--AGNGTVGF 222
                 467776799********9987654..67776655 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.1
      TGT_C2  26 itrsatgrirqvlvdgerla 45 
                 +t    +rir++l +g+ + 
  EFC37866.1 250 FTDQHNNRIRKILENGNIIT 269
                 4544789*******998775 PP

>> MJ1316  MJ1316 RNA cyclic group end recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.057        79      60      73 ..      31      44 ..       7      45 .. 0.85
   2 ?    3.7   0.0     0.074     1e+02      60      73 ..      87     100 ..      67     101 .. 0.85
   3 ?    4.0   0.0     0.062        86      60      73 ..     143     156 ..     122     157 .. 0.87
   4 ?    3.7   0.0     0.074     1e+02      60      73 ..     199     212 ..     179     213 .. 0.85
   5 ?   -1.7   0.0       3.7   5.1e+03      62      73 ..     257     268 ..     239     268 .. 0.72

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.057
      MJ1316 60 lHRiryikrkgevv 73
                 HRir+i  +g++v
  EFC37866.1 31 NHRIRKILENGNIV 44
                6**********998 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.074
      MJ1316  60 lHRiryikrkgevv 73 
                  HRir+i  +g+++
  EFC37866.1  87 NHRIRKILENGNII 100
                 5*********9998 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.062
      MJ1316  60 lHRiryikrkgevv 73 
                  HRir+i  +g++v
  EFC37866.1 143 NHRIRKILENGNIV 156
                 5**********998 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.074
      MJ1316  60 lHRiryikrkgevv 73 
                  HRir+i  +g+++
  EFC37866.1 199 NHRIRKILENGNII 212
                 5*********9998 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 3.7
      MJ1316  62 Riryikrkgevv 73 
                 Rir+i  +g+++
  EFC37866.1 257 RIRKILENGNII 268
                 888888888776 PP

>> ParBc_2  Putative ParB-like nuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0023       3.1      43      62 ..     209     255 ..      11     276 .. 0.74
   2 ?   -1.3   0.0       1.5   2.1e+03      43      59 ..     292     308 .]     259     308 .] 0.85

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0023
                 B...........................EEEEEE-STT-EEE-S-HH CS
     ParBc_2  43 k...........................lvpvVigpdgelYliDhHH 62 
                                             +  v +  ++e+Y +D+H+
  EFC37866.1 209 GniitiagngtvgfsgdngpatnaqlynPSSVFVSSNNEVYFTDQHN 255
                 23333333333444444444444444445566666677777777775 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.5
                 BEEEEEE-STT-EEE-S CS
     ParBc_2  43 klvpvVigpdgelYliD 59 
                 +++ v +  ++e+Y++D
  EFC37866.1 292 NPNSVFVSSNNEVYITD 308
                 467788889999***99 PP

>> MHC_I_3  MHC-I family domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0       0.5   6.9e+02     164     196 ..       9      42 ..       5      43 .. 0.75
   2 !    9.4   0.0   0.00048      0.66     105     196 ..      63     154 ..      59     155 .. 0.83
   3 ?    2.8   0.0     0.051        70     105     150 ..     175     220 ..     171     268 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.5
                 HHHHT-HH.HHHHHHHHHHTHHHHHHHHHHHHTH CS
     MHC_I_3 164 kllNqdqv.tketvqrllsDtCPrfllglldaGk 196
                 +l+N   v +++  + ++ D+C + ++ +l+ G+
  EFC37866.1   9 QLFNPSSVfVSSNNEVYIADFCNHRIRKILENGN 42 
                 566665551455667889************9995 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00048
                 HHSS-SSEEEEEEEEEEEESTTEEEEEEEEEETTEEEEEEETTEEEE.-TTS-GGGHHHHHHHHT-HH.HHHHHHHHHHTHHHHHHHHHHHHTH CS
     MHC_I_3 105 elkleYPfevqlsaGCelhpgeasvsFlrvAyqgsdllsfqntswlp.spkggsraqevikllNqdqv.tketvqrllsDtCPrfllglldaGk 196
                 + +++YP  v +s   e+++ + s++ +r   +  +++++ ++  +  s + g    +  +l+N   v +++  + ++ D+C + ++ +l+ G+
  EFC37866.1  63 NAQFNYPCSVFVSSKNEVYITDYSNHRIRKILENGNIITIAGNGTVGfSGDNGP--ATNAQLYNPSSVfVSSNNEVYIADFCNHRIRKILENGN 154
                 6799************************************99987651444444..445789998877256677889**************995 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.051
                 HHSS-SSEEEEEEEEEEEESTTEEEEEEEEEETTEEEEEEETTEEE CS
     MHC_I_3 105 elkleYPfevqlsaGCelhpgeasvsFlrvAyqgsdllsfqntswl 150
                 + +++YP  v +s   e+++ + s++ +r   +  +++++ ++  +
  EFC37866.1 175 NAQFNYPCSVFVSSKNEVYITDYSNHRIRKILENGNIITIAGNGTV 220
                 6799*******************99999999999999988877654 PP

>> Plasmo_rep  Plasmodium repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.1    0.0067       9.2       1       8 [.      19      26 ..      19      28 .. 0.86
   2 ?    4.0   0.2     0.027        37       2      11 ..      76      85 ..      75      86 .. 0.82
   3 ?   -2.4   0.0       2.6   3.6e+03       3       9 ..     119     125 ..     119     125 .. 0.84
   4 ?    5.9   0.1    0.0067       9.2       1       8 [.     131     138 ..     131     140 .. 0.86
   5 ?    4.0   0.2     0.027        37       2      11 ..     188     197 ..     187     198 .. 0.82
   6 ?   -2.4   0.0       2.6   3.6e+03       3       9 ..     231     237 ..     231     237 .. 0.84
   7 ?    6.4   0.6    0.0047       6.4       1      11 [.     243     253 ..     243     255 .. 0.90
   8 ?   -0.1   0.1       0.5   6.8e+02       3      10 ..     287     294 ..     287     295 .. 0.86
   9 ?    8.3   0.3    0.0012       1.7       1      10 [.     299     308 .]     299     308 .] 0.91

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0067
  Plasmo_rep  1 FsDnEvYs 8 
                +s+nEvY+
  EFC37866.1 19 SSNNEVYI 26
                69*****8 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.027
  Plasmo_rep  2 sDnEvYspkq 11
                s nEvY++++
  EFC37866.1 76 SKNEVYITDY 85
                679****995 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 2.6
  Plasmo_rep   3 DnEvYsp 9  
                 + ++Y+p
  EFC37866.1 119 NAQLYNP 125
                 679**98 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.0067
  Plasmo_rep   1 FsDnEvYs 8  
                 +s+nEvY+
  EFC37866.1 131 SSNNEVYI 138
                 69*****8 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.027
  Plasmo_rep   2 sDnEvYspkq 11 
                 s nEvY++++
  EFC37866.1 188 SKNEVYITDY 197
                 679****995 PP

  == domain 6  score: -2.4 bits;  conditional E-value: 2.6
  Plasmo_rep   3 DnEvYsp 9  
                 + ++Y+p
  EFC37866.1 231 NAQLYNP 237
                 679**98 PP

  == domain 7  score: 6.4 bits;  conditional E-value: 0.0047
  Plasmo_rep   1 FsDnEvYspkq 11 
                 +s+nEvY ++q
  EFC37866.1 243 SSNNEVYFTDQ 253
                 69*****9998 PP

  == domain 8  score: -0.1 bits;  conditional E-value: 0.5
  Plasmo_rep   3 DnEvYspk 10 
                 + ++Y+p+
  EFC37866.1 287 NAQLYNPN 294
                 679****8 PP

  == domain 9  score: 8.3 bits;  conditional E-value: 0.0012
  Plasmo_rep   1 FsDnEvYspk 10 
                 +s+nEvY+++
  EFC37866.1 299 SSNNEVYITD 308
                 6*******97 PP

>> potato_inhibit  Potato inhibitor I family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.046        64      29      58 ..      16      45 ..      11      47 .. 0.80
   2 ?   -0.1   0.0       1.1   1.5e+03      31      56 ..      74      99 ..      67     103 .. 0.73
   3 ?    4.3   0.0     0.046        64      29      58 ..     128     157 ..     123     159 .. 0.80
   4 ?   -0.1   0.0       1.1   1.5e+03      31      56 ..     186     211 ..     179     215 .. 0.73
   5 ?   -2.3   0.0       5.3   7.4e+03      31      51 ..     242     262 ..     236     269 .. 0.59

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.046
  potato_inhibit 29 vevvpegspvtadfrcnRVrvfvdengiVa 58
                    v v  ++++++adf+ +R+r + ++ +iV+
      EFC37866.1 16 VFVSSNNEVYIADFCNHRIRKILENGNIVT 45
                    4466778899**********9998878775 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 1.1
  potato_inhibit 31 vvpegspvtadfrcnRVrvfvdengi 56
                    v  +++++++d+  +R+r + ++ +i
      EFC37866.1 74 VSSKNEVYITDYSNHRIRKILENGNI 99
                    55667789999999999977665454 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.046
  potato_inhibit  29 vevvpegspvtadfrcnRVrvfvdengiVa 58 
                     v v  ++++++adf+ +R+r + ++ +iV+
      EFC37866.1 128 VFVSSNNEVYIADFCNHRIRKILENGNIVT 157
                     4466778899**********9998878775 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 1.1
  potato_inhibit  31 vvpegspvtadfrcnRVrvfvdengi 56 
                     v  +++++++d+  +R+r + ++ +i
      EFC37866.1 186 VSSKNEVYITDYSNHRIRKILENGNI 211
                     55667789999999999977665454 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 5.3
  potato_inhibit  31 vvpegspvtadfrcnRVrvfv 51 
                     v  +++++ +d   nR+r + 
      EFC37866.1 242 VSSNNEVYFTDQHNNRIRKIL 262
                     445555666777777777555 PP

>> DUF4792  Domain of unknown function (DUF4792)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       1.6   2.2e+03      22      50 ..      19      47 ..      14      56 .. 0.80
   2 ?    4.8   0.1     0.018        25      21      50 ..      74     103 ..      52     105 .. 0.91
   3 ?   -1.2   0.0       1.4   1.9e+03      21      50 ..     130     159 ..     125     170 .. 0.81
   4 ?    4.8   0.1     0.018        25      21      50 ..     186     215 ..     164     217 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.6
     DUF4792 22 seskklsveddshkewgyyLnkGSqvnis 50
                s ++++ + d  +++++ +L  G+ v+i+
  EFC37866.1 19 SSNNEVYIADFCNHRIRKILENGNIVTIA 47
                56677788888888999999999999986 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.018
     DUF4792  21 wseskklsveddshkewgyyLnkGSqvnis 50 
                 +s ++++ + d+s+++++ +L  G+ ++i+
  EFC37866.1  74 VSSKNEVYITDYSNHRIRKILENGNIITIA 103
                 7889999********************995 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.4
     DUF4792  21 wseskklsveddshkewgyyLnkGSqvnis 50 
                 +s ++++ + d  +++++ +L  G+ v+i+
  EFC37866.1 130 VSSNNEVYIADFCNHRIRKILENGNIVTIA 159
                 566677788888888999999999999986 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.018
     DUF4792  21 wseskklsveddshkewgyyLnkGSqvnis 50 
                 +s ++++ + d+s+++++ +L  G+ ++i+
  EFC37866.1 186 VSSKNEVYITDYSNHRIRKILENGNIITIA 215
                 7889999********************995 PP

>> NPH-II  RNA helicase NPH-II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.35   4.9e+02     114     144 ..      17      47 ..      14      55 .. 0.85
   2 ?    4.7   0.0     0.018        25     107     146 ..      66     105 ..      57     125 .. 0.87
   3 ?    0.8   0.0      0.28   3.9e+02     114     144 ..     129     159 ..     113     170 .. 0.87
   4 ?    4.6   0.0     0.019        26     108     146 ..     179     217 ..     171     238 .. 0.87
   5 ?   -1.5   0.0       1.5   2.1e+03     118     143 ..     245     270 ..     237     276 .. 0.71

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.35
      NPH-II 114 ylkckkgteiaeldeavlrGLvegGNklkiF 144
                 ++ ++++  ia++ ++ +r ++e GN + i 
  EFC37866.1  17 FVSSNNEVYIADFCNHRIRKILENGNIVTIA 47 
                 66777888899999************99885 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.018
      NPH-II 107 isfEcYsylkckkgteiaeldeavlrGLvegGNklkiFsn 146
                   + c  ++ +k++  i++  ++ +r ++e GN + i  n
  EFC37866.1  66 FNYPCSVFVSSKNEVYITDYSNHRIRKILENGNIITIAGN 105
                 55679999**************************999655 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.28
      NPH-II 114 ylkckkgteiaeldeavlrGLvegGNklkiF 144
                 ++ ++++  ia++ ++ +r ++e GN + i 
  EFC37866.1 129 FVSSNNEVYIADFCNHRIRKILENGNIVTIA 159
                 66777888999999************99885 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.019
      NPH-II 108 sfEcYsylkckkgteiaeldeavlrGLvegGNklkiFsn 146
                  + c  ++ +k++  i++  ++ +r ++e GN + i  n
  EFC37866.1 179 NYPCSVFVSSKNEVYITDYSNHRIRKILENGNIITIAGN 217
                 5679999**************************999655 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 1.5
      NPH-II 118 kkgteiaeldeavlrGLvegGNklki 143
                 +++   ++  ++ +r ++e GN + i
  EFC37866.1 245 NNEVYFTDQHNNRIRKILENGNIITI 270
                 44455566677888999999999887 PP

>> Coatomer_WDAD  Coatomer WD associated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.1    0.0086        12      42      99 ..      39      96 ..      18     112 .. 0.80
   2 ?    4.9   0.2    0.0083        11      41      99 ..     150     208 ..     117     220 .. 0.80
   3 ?    2.7   0.1     0.039        53      42     101 ..     207     266 ..     204     275 .. 0.83
   4 ?    1.0   0.0      0.12   1.6e+02      42      81 ..     263     302 ..     251     308 .] 0.85

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0086
                   XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXX CS
  Coatomer_WDAD 42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvkifknfke 99
                   +ng++v++ g+g+y +    +  ++a+ +    v+vss++ +++++ ++ +i k +++
     EFC37866.1 39 ENGNIVTIAGNGNYGFSGDNGPATNAQFNYPCSVFVSSKNEVYITDYSNHRIRKILEN 96
                   79***********************************555555555555566444455 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0083
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXX CS
  Coatomer_WDAD  41 npngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvkifknfke 99 
                     +ng++v++ g+g+y +    +  ++a+ +    v+vss++ +++++ ++ +i k +++
     EFC37866.1 150 LENGNIVTIAGNGNYGFSGDNGPATNAQFNYPCSVFVSSKNEVYITDYSNHRIRKILEN 208
                    579***********************************555555555555566444444 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.039
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXX CS
  Coatomer_WDAD  42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnrfavlessksvkifknfkekk 101
                    +ng+++++ g+g+  +    +  ++a+    + v+vssn+ ++++++++ +i k +++ +
     EFC37866.1 207 ENGNIITIAGNGTVGFSGDNGPATNAQLYNPSSVFVSSNNEVYFTDQHNNRIRKILENGN 266
                    69999999999999999999999999999999*****99988889899989966666655 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.12
                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Coatomer_WDAD  42 pngrfvlVcgdgeyiiytalalrnkaygkgldfvwvssnr 81 
                    +ng+++++ g+g+y +    +  ++a+    + v+vssn+
     EFC37866.1 263 ENGNIITIAGNGNYGFSGDNGPATNAQLYNPNSVFVSSNN 302
                    69****************999999999999999***9665 PP

>> Sua5_yciO_yrdC  Telomere recombination
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.076     1e+02       2      22 ..      37      57 ..      36      65 .. 0.88
   2 ?   -3.0   0.0       3.2   4.5e+03       2      21 ..      93     112 ..      92     119 .. 0.81
   3 ?    2.3   0.0     0.076     1e+02       2      22 ..     149     169 ..     148     177 .. 0.88
   4 ?   -3.0   0.0       3.2   4.5e+03       2      21 ..     205     224 ..     204     231 .. 0.81
   5 ?    2.4   0.0      0.07        96       2      22 ..     261     281 ..     260     292 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.076
                    HHHTTSEEEEE-SSSEEEEEE CS
  Sua5_yciO_yrdC  2 alrkGgivaiptetvYgLacd 22
                    +l++G+iv i + + Yg+  d
      EFC37866.1 37 ILENGNIVTIAGNGNYGFSGD 57
                    799**************9877 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 3.2
                     HHHTTSEEEEE-SSSEEEEE CS
  Sua5_yciO_yrdC   2 alrkGgivaiptetvYgLac 21 
                     +l++G+i+ i + +  g+  
      EFC37866.1  93 ILENGNIITIAGNGTVGFSG 112
                     79999999999998877665 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.076
                     HHHTTSEEEEE-SSSEEEEEE CS
  Sua5_yciO_yrdC   2 alrkGgivaiptetvYgLacd 22 
                     +l++G+iv i + + Yg+  d
      EFC37866.1 149 ILENGNIVTIAGNGNYGFSGD 169
                     799**************9877 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 3.2
                     HHHTTSEEEEE-SSSEEEEE CS
  Sua5_yciO_yrdC   2 alrkGgivaiptetvYgLac 21 
                     +l++G+i+ i + +  g+  
      EFC37866.1 205 ILENGNIITIAGNGTVGFSG 224
                     79999999999998877665 PP

  == domain 5  score: 2.4 bits;  conditional E-value: 0.07
                     HHHTTSEEEEE-SSSEEEEEE CS
  Sua5_yciO_yrdC   2 alrkGgivaiptetvYgLacd 22 
                     +l++G+i+ i + + Yg+  d
      EFC37866.1 261 ILENGNIITIAGNGNYGFSGD 281
                     799**************9887 PP

>> YdfZ  YdfZ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1      0.16   2.2e+02       5      26 ..      33      54 ..      31      62 .. 0.90
   2 ?    3.5   0.1     0.068        94       5      26 ..      89     110 ..      86     137 .. 0.89
   3 ?    2.4   0.1      0.16   2.2e+02       5      26 ..     145     166 ..     143     174 .. 0.90
   4 ?    3.4   0.1     0.072     1e+02       5      26 ..     201     222 ..     198     247 .. 0.91
   5 ?    0.8   0.1      0.48   6.6e+02       5      26 ..     257     278 ..     254     303 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.16
        YdfZ  5 RnrNaittGsrVMiagtgevgv 26
                R r  ++ G  V iag+g+ g+
  EFC37866.1 33 RIRKILENGNIVTIAGNGNYGF 54
                789999************9875 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.068
        YdfZ   5 RnrNaittGsrVMiagtgevgv 26 
                 R r  ++ G  + iag+g+vg+
  EFC37866.1  89 RIRKILENGNIITIAGNGTVGF 110
                 789999**************97 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.16
        YdfZ   5 RnrNaittGsrVMiagtgevgv 26 
                 R r  ++ G  V iag+g+ g+
  EFC37866.1 145 RIRKILENGNIVTIAGNGNYGF 166
                 789999************9875 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.072
        YdfZ   5 RnrNaittGsrVMiagtgevgv 26 
                 R r  ++ G  + iag+g+vg+
  EFC37866.1 201 RIRKILENGNIITIAGNGTVGF 222
                 789999**************97 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.48
        YdfZ   5 RnrNaittGsrVMiagtgevgv 26 
                 R r  ++ G  + iag+g+ g+
  EFC37866.1 257 RIRKILENGNIITIAGNGNYGF 278
                 7899999***********9886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       358  (0.0199677); expected 358.6 (0.02)
Passed bias filter:                      247  (0.0137766); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.58u 0.34s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1771.94
//
Query:       EFC37867.1  [L=390]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.3e-10   39.3   3.5    8.5e-10   38.9   0.4    2.7  3  BTB            BTB/POZ domain
  ------ inclusion threshold ------
        4.2    6.8   4.7        2.6    7.5   1.2    2.2  2  Clathrin-link  Clathrin, heavy-chain linker


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1      0.24   2.1e+03      57      93 ..      65     102 ..      47     115 .. 0.65
   2 ?   -1.3   0.0      0.29   2.6e+03      75      98 ..     127     150 ..     121     163 .. 0.76
   3 !   38.9   0.4   9.4e-14   8.5e-10       9     107 ..     223     324 ..     215     328 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.24
                 TTSGHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHHHH CS
         BTB  57 ddvepeafealLefiYtgeleit.seenleelLaaadl 93 
                 +  + e++++l++ +  ++ +++ s+e++ ++L +  l
  EFC37867.1  65 SSSQQEIIQKLIDSLLYDKNKVKfSKEEVLDVLFILGL 102
                 55566777888887766666666677788887766555 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.29
                 EEEC-CGGGHHHHHHHH.HHHT-HH CS
         BTB  75 eleitseenleelLaaa.dllqipr 98 
                 +l+++ +e++e+lL++  + + i++
  EFC37867.1 127 NLTFK-WETIENLLKTCnEEFGIQN 150
                 56675.9999999999877777776 PP

  == domain 3  score: 38.9 bits;  conditional E-value: 9.4e-14
                 TTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST....TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHH CS
         BTB   9 elcDvtlvvgdgkefkahkavLaarSpyFkalftsk....eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlkkac 103
                 + +Dv +++g++k +++hk vL+++S+ F+alf s+      ++++    + +  + e +e++++++Y+  ++  +  ++  lL +a + +i+ l++ c
  EFC37867.1 223 KTSDVKIKMGQNKYLYCHKTVLSSSSTLFNALFDSGscfsDLSDDGI-FTPDESEDLELLEIVIKYCYRISIDKIDAVKIIGLLDMAMKHEIQYLINYC 320
                 789*********************************76543344442.3555777889**********99988777899******************** PP

                 HHHH CS
         BTB 104 eefl 107
                 ++ +
  EFC37867.1 321 KNNF 324
                 9865 PP

>> Clathrin-link  Clathrin, heavy-chain linker
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   1.2   0.00029       2.6       6      15 ..     150     159 ..     148     159 .. 0.93
   2 ?   -0.6   0.1       0.1   9.1e+02       4      11 ..     316     323 ..     316     323 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00029
  Clathrin-link   6 PYIlntLnNp 15 
                    +YIl++LnN+
     EFC37867.1 150 NYILDQLNNH 159
                    8********5 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.1
  Clathrin-link   4 IIPYIlnt 11 
                    +I+Y++n+
     EFC37867.1 316 LINYCKNN 323
                    59****97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (390 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       900  (0.050198); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 2176.36
//
Query:       EFC37868.1  [L=300]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.5e-42  145.0   1.0    3.1e-42  144.7   1.0    1.1  1  NmrA             NmrA-like family
    2.1e-20   73.4   0.4    5.4e-20   72.1   0.2    1.8  1  NAD_binding_10   NAD(P)H-binding
    1.6e-08   34.4   0.2    1.7e-07   31.0   0.1    2.3  2  Epimerase        NAD dependent epimerase/dehydratase family
    8.8e-07   29.1   3.4      1e-06   28.9   0.5    2.3  2  DapB_N           Dihydrodipicolinate reductase, N-terminus
    4.2e-06   26.9   0.4      9e-06   25.8   0.4    1.5  1  Shikimate_DH     Shikimate / quinate 5-dehydrogenase
    2.1e-05   23.7   0.1    4.2e-05   22.7   0.1    1.5  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
    0.00018   21.0   0.9       0.17   11.3   0.1    3.0  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    0.00038   20.9   0.1    0.00083   19.8   0.1    1.7  1  Semialdhyde_dh   Semialdehyde dehydrogenase, NAD binding doma
     0.0015   17.8   1.3     0.0035   16.5   0.3    2.1  2  NAD_binding_4    Male sterility protein
     0.0017   18.7   1.4     0.0023   18.2   0.3    1.8  2  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
     0.0019   18.9   0.2     0.0068   17.2   0.1    2.0  2  GARS_N           Phosphoribosylglycinamide synthetase, N doma
     0.0038   17.9   3.1       0.35   11.6   0.6    2.3  2  DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomer
  ------ inclusion threshold ------
      0.011   15.8   0.5      0.026   14.6   0.5    1.6  1  Ldh_1_N          lactate/malate dehydrogenase, NAD binding do
       0.02   14.8   0.5      0.045   13.7   0.5    1.6  1  KR               KR domain
      0.025   13.7   0.8        1.7    7.7   0.2    2.7  3  Polysacc_synt_2  Polysaccharide biosynthesis protein
       0.11   12.3   0.9       0.56   10.1   0.9    2.1  1  Peptidase_M4_C   Thermolysin metallopeptidase, alpha-helical 
       0.17   12.0   1.9       0.89    9.8   0.2    2.4  2  DUF211           Uncharacterized ArCR, COG1888


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  144.7   1.0   2.9e-45   3.1e-42       1     230 [.       6     230 ..       6     251 .. 0.90

  Alignments for each domain:
  == domain 1  score: 144.7 bits;  conditional E-value: 2.9e-45
                 EEESSTTSHHHHHHHHHHHH.HT-EEEEEES-S-SHHHHHHHHSTTEEEES-TT-H.HHHHHHHTT-SEEEE---GGS-HHHH.HHHHHHHHHHHS-SE CS
        NmrA   1 IlviGaTGrqGksvvrallk.aghkvralvRdtkselakslkeaGvelvkgdlddk.eslvealkgvdvvfsvtgfyskeied.gkklvdAakeaGvkh 96 
                 +lv+GaTGr+G+ +++all+    +v al+R+ ++ +a++lke+Gv+l++g l+d  e l++a ++vdv++s++   ++ i d + +l +Aak+aGvk+
  EFC37868.1   6 VLVVGATGRLGSLITSALLNkPTVQVSALIRKGSETKAEQLKEKGVQLISGALNDSvEDLQQACQNVDVIISAVIGSEDTIMDgQLRLLEAAKKAGVKR 104
                 79***************9987899****************************9985499*************999887777762568************ PP

                 EEEEE---GG.GT.SSS---TTTHHHHHHHHHHHHCTS-EEEEEE-EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE-HHHHHHHHHHHHHH CS
        NmrA  97 fiySslgddndrsnaeepavphfdsKaeieeyvralgipytfvyagffmenflsllaqlkvgdtappedkvtllgpgnpkavlldaeeDiGafvikilk 195
                 fi+S + +d     a++ +++hfd+  ++ e v+++gi yt+++ g+fme f +++ +  + dt++ + ++  +++  ++     + eD +++v++++ 
  EFC37868.1 105 FIPSDYSADY--LRASIGDHDHFDMRKQVAEQVKQSGIGYTIFLNGVFMETFFGPFLN--IIDTKNHKITYYGSADTLVDTT---TYEDAAKYVVEAAL 196
                 *******999..4568889***********************************9999..8888877755555555554433...67************ PP

                 HHHHHTTEEEEE-SEEE-HHHHHHHHHHHHTS-EE CS
        NmrA 196 dprklkgkriklagntlsgneivelfekkigktvk 230
                 dp++l+ k+++++g+ +s++++++ +e+++g +++
  EFC37868.1 197 DPEQLN-KIVSVSGDRVSYTQLAQQIEQVTGHKIT 230
                 ***994.7899********************9986 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.1   0.2   5.1e-23   5.4e-20       1     183 [.      10     197 ..      10     198 .. 0.72

  Alignments for each domain:
  == domain 1  score: 72.1 bits;  conditional E-value: 5.1e-23
                     TTTSHHHHHHHHHHHHC-T-EEEEEETT..HHHCHHHHCTTTCEEEE--TT-.CCHHHHHHTT-SEEEES-.--TCCHHHHHHHHHHHHHHCT-- CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRn..peklaeleaeeglevvegdvtd.vedlaealkgadaVvsal.ggggkdeegaknivdaakeagvk 91 
                     GAtG+ G+l+++ ll++  ++v al+R+  + k+++l+ e+g+++++g ++d vedl++a++++d+++sa+ g++++  +g  ++++aak+agvk
      EFC37868.1  10 GATGRLGSLITSALLNKPTVQVSALIRKgsETKAEQLK-EKGVQLISGALNDsVEDLQQACQNVDVIISAViGSEDTIMDGQLRLLEAAKKAGVK 103
                     9**************************95566778886.7**********9847*****************6777779999************** PP

                     EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEEEEEEE-C...........EE-ST--SEEEEETTSS----EEEHHHHHH CS
  NAD_binding_10  92 RfvlvsaigvgdevpgefgewnkellkaylaakraaeellrasgldwTivrpgg...........LtdepttkyrvvekgepfkggsisradVAd 175
                     Rf+   +   +     + g+       + ++  ++ +e +++sg+ +Ti   g            + d +++k+    + +++ + +++ +d A+
      EFC37868.1 104 RFIPSDYSADY--LRASIGDH------DHFDMRKQVAEQVKQSGIGYTIFLNGVfmetffgpflnIIDTKNHKITYYGSADTLVD-TTTYEDAAK 189
                     ****8764433..22333332......2345567888889999999999998883333333322222222333332333333333.567777777 PP

                     HHHHHCTX CS
  NAD_binding_10 176 vlvavldd 183
                     ++v+++ d
      EFC37868.1 190 YVVEAALD 197
                     77777665 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.1   1.6e-10   1.7e-07       1     111 [.       6     106 ..       6     109 .. 0.91
   2 ?    0.5   0.0      0.33   3.5e+02     194     231 ..     163     200 ..     129     208 .. 0.80

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 1.6e-10
                 EEEETTTSHHHHHHHHHHHHCT.SEEEEEES-STTTTCHHCHHC..EEEE--TT-HH.HHHHHHHHHT-SEEEE--S---HHHHHHSHHHHHHHHTHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekg.yevigldrlssasntarledl..elveldltdrs.alerlfkeeqpdavihlAavggvaassedpadfieknlqgt 95 
                 +lV+GatG +Gs ++ all+k  ++v +l r+ s+ + ++l+++  +l+ + l d++ +l+++++  ++d++i +         ++  +d+i+    g+
  EFC37868.1   6 VLVVGATGRLGSLITSALLNKPtVQVSALIRKGSETKAEQLKEKgvQLISGALNDSVeDLQQACQ--NVDVIISA---------VIGSEDTIM---DGQ 90 
                 79********************777*******99999999999999**********989******..9******9.........555566665...7** PP

                 HHHHHHHHHHTCTEEE CS
   Epimerase  96 lnlleaarkagvkrll 111
                 l+lleaa+kagvkr++
  EFC37868.1  91 LRLLEAAKKAGVKRFI 106
                 **************97 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.33
                 HTTSSSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT CS
   Epimerase 194 legkqevtllgdgtalRdflyveDvaeaillvlehvda 231
                  ++ +++t++g+ + l d    eD+a+ ++ ++  +++
  EFC37868.1 163 DTKNHKITYYGSADTLVDTTTYEDAAKYVVEAALDPEQ 200
                 3334699999*999999999999999999988777665 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   0.5   9.7e-10     1e-06       1      72 [.       4      76 ..       4     103 .. 0.78
   2 ?    0.0   0.1      0.83   8.8e+02      66      85 ..     173     192 ..     156     223 .. 0.71

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 9.7e-10
                EEEEEETTTSHHHHHHHHHHHHSTTEEEEEEEETTCSTTTTTBHHHHSSSS--S-BEB...SSHHHHHHH-SEEE CS
      DapB_N  1 ikvavvGasGrmGkevvkaveeaedlelvaavdrkeselegkdagellglgklgvavt...ddleevlekadvli 72
                +kv+vvGa+Gr+G+ +++a+ +++ ++++a + + + e++++++ e  g++ ++ a++   +dl+++++++dv+i
  EFC37868.1  4 TKVLVVGATGRLGSLITSALLNKPTVQVSALIRKGS-ETKAEQLKE-KGVQLISGALNdsvEDLQQACQNVDVII 76
                59****************************999976.555555543.3444333344323468888888899999 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.83
                 HH-SEEEE-S-HHHHHHHHH CS
      DapB_N  66 ekadvliDFTtpeavlenlk 85 
                  +ad l+D Tt e + +++ 
  EFC37868.1 173 GSADTLVDTTTYEDAAKYVV 192
                 44899999988766555543 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.4   8.5e-09     9e-06      11      98 ..       2      94 ..       1     106 [. 0.77

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 8.5e-09
                  TT-EEEEES-.SHHHHHHHHHHHCCT-CEEEEEES..SHHHHHHHHHHHT.ET..-EEEEGCGHHHHHHT-SEEEE-SSSSS-SB-HHHHHCC CS
  Shikimate_DH 11 kekkvlliGa.GemaelvakhLlakgvkkvvvaNR..tlerakelaeelkgee..iealkleelkellaeadvvisataseepilekeeveea 98
                  ++ kvl++Ga G++++l++++Ll+k   +v  + R  + ++a++l e+  +    +   ++e+l+++ +++dv+isa+  +e  +  ++++ +
    EFC37868.1  2 SSTKVLVVGAtGRLGSLITSALLNKPTVQVSALIRkgSETKAEQLKEKGVQLIsgALNDSVEDLQQACQNVDVIISAVIGSEDTIMDGQLRLL 94
                  678******88**************88888776663378999***98864432013567899***************9887777776666544 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.1     4e-08   4.2e-05       1     112 [.       7     106 ..       7     114 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 4e-08
   3Beta_HSD   1 vvtGgaGFlGralvkeLvrleelkevrvlDlrespelleelskvnvkkviegDvtdk.dkleealegvdvvihlaslvdvagkltedeimkvnvkGTrn 98 
                 +v+G++G lG+ + ++L++     +v +l +r+++e++ e+ k +  ++i g ++d  ++l++a+++vdv+i       v g  +ed+im     G   
  EFC37868.1   7 LVVGATGRLGSLITSALLNKPT-VQVSAL-IRKGSETKAEQLKEKGVQLISGALNDSvEDLQQACQNVDVIISA-----VIG--SEDTIM----DGQLR 92 
                 69***************98774.555555.677777766666666666*******96489***********987.....777..567555....68889 PP

   3Beta_HSD  99 vleacvkagvrvlv 112
                 +lea++kagv++++
  EFC37868.1  93 LLEAAKKAGVKRFI 106
                 9*********9998 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.1   0.00016      0.17       1     118 [.       7     102 ..       7     112 .. 0.69
   2 ?    5.3   0.1     0.011        11     202     280 ..     160     239 ..     148     259 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00016
                    EEETTTSHHHHHHHHHHHHC.T-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHTTSH CS
  GDP_Man_Dehyd   1 LiTGiaGfiGsylaelLlek.gyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevqpdevynLAAqshVdvsfekP 95 
                    L+ G +G  Gs ++  Ll+k   +v  ++r+ s+++++++++          + ++l++g l+Ds  +e+l + +q            Vdv ++  
     EFC37868.1   7 LVVGATGRLGSLITSALLNKpTVQVSALIRKGSETKAEQLKE----------KGVQLISGALNDS--VEDLQQACQ-----------NVDVIISAV 79 
                    899***************9967899999**999999877754..........3467999999993..444444443...........333334433 PP

                    HHHHHHHTHHHHHHHHHHHHCT. CS
  GDP_Man_Dehyd  96 eytaevnvlGtlrLLeairalgl 118
                        ++ + G lrLLea++++g+
     EFC37868.1  80 IGSEDTIMDGQLRLLEAAKKAGV 102
                    34444455566666666666665 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.011
                    HHHHTTS-C-EECTTTT-EEEEEEHHHHHHHHHH.HHHCSS---EEE-TT-EEECHHCHHCCHHCCCHHHHHH....... CS
  GDP_Man_Dehyd 202 arialgkqevlylGnldakRdwghvkDyveamwl.mlqqdkpedyviatgethsvrefvelaflelgktiewegkgeeev 280
                      i+ ++++++y+G  d   d +  +D ++ ++  +l  ++ +++v  +g+ +s  ++++   + +g +i+ e kg  e 
     EFC37868.1 160 NIIDTKNHKITYYGSADTLVDTTTYEDAAKYVVEaALDPEQLNKIVSVSGDRVSYTQLAQQIEQVTGHKITLERKGSVED 239
                    55677789999******************9865527888999***************99988888888888776654432 PP

>> Semialdhyde_dh  Semialdehyde dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.1   7.9e-07   0.00083       1      74 [.       5      79 ..       5     114 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 7.9e-07
                    EEEEETTTSHHHHHHHHHHHCTSSEEEEEEEESTT.TTTSBHHHHSG.GGTTTECEBEEEGGGGGCTT-SEEEE-S CS
  Semialdhyde_dh  1 kvaivGatGyvGqellrlLeehpevelvvllsssr.saGkklaeavk.aleegkdlkvedvdeeelkevdivflal 74
                    kv +vGatG  G+ +   L ++p v++++l+ + +  + ++l+e+    +++  + +ved  +++ ++vd++++a+
      EFC37868.1  5 KVLVVGATGRLGSLITSALLNKPTVQVSALIRKGSeTKAEQLKEKGVqLISGALNDSVED-LQQACQNVDVIISAV 79
                    799**************************9976664344444444332667777777777.667779******996 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.3   3.3e-06    0.0035       2      39 ..       9      45 ..       8      76 .. 0.87
   2 ?   -2.3   0.0       1.9     2e+03     118     137 ..     191     211 ..     176     253 .. 0.58

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3.3e-06
                   E-TTSHHHHHHHHHHHHHS-.TEEEEEE-SSSHHHHHH CS
  NAD_binding_4  2 TGaTGFLGkvLlekLLrttpevkiyllvRaksgesaee 39
                    GaTG LG+ +   LL++ + v++ +l+R+ s+++ae+
     EFC37868.1  9 VGATGRLGSLITSALLNKPT-VQVSALIRKGSETKAEQ 45
                   6***************9986.8*********9988877 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.9
                    HHHHHTSSS--.-EEEEEE.G CS
  NAD_binding_4 118 vlelakklkklkvllhvST.a 137
                    v+e a   ++l+ ++ vS   
     EFC37868.1 191 VVEAALDPEQLNKIVSVSGdR 211
                    444444444444444444433 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.3   2.2e-06    0.0023       1      93 [.       6     101 ..       6     108 .. 0.77
   2 ?   -2.1   0.0       4.2   4.4e+03      28      28 ..     205     205 ..     174     253 .. 0.57

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 2.2e-06
                      EEEE--.SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHHTTTCEEEEE--TTTHHHHHHHHHTTSSEEEE-SSGG......GHHHHHH CS
  Sacchrp_dh_NADP   1 vliiGa.GsvGqavaellarhfdvdaeitvadrskeklealaakalgvrfeaialdaenyeavLaallkegdlvvnlsppi......ssldvlk 87 
                      vl++Ga G+ G+ ++  l+++  v  ++    r+ ++ +a+  k++gv++++ al+ + +e+ L+++++  d++++++           l +l+
       EFC37868.1   6 VLVVGAtGRLGSLITSALLNKPTV--QVSALIRKGSETKAEQLKEKGVQLISGALN-DSVED-LQQACQNVDVIISAVIGSedtimdGQLRLLE 95 
                      89**********************..666666666655555555689999999987.55777.**************98875545555555555 PP

                      HHHHHT CS
  Sacchrp_dh_NADP  88 aCietg 93 
                      a+ ++g
       EFC37868.1  96 AAKKAG 101
                      555555 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 4.2
                      E CS
  Sacchrp_dh_NADP  28 t 28 
                      +
       EFC37868.1 205 V 205
                      2 PP

>> GARS_N  Phosphoribosylglycinamide synthetase, N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.1   6.4e-06    0.0068       2      87 ..       5     112 ..       4     114 .. 0.77
   2 ?   -2.4   0.0       8.1   8.5e+03      34      47 ..     234     247 ..     197     271 .. 0.58

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 6.4e-06
                 EEEEEESSHHHHHHH.HHHTTSTTESEEEEEE--CGG...................TTHHHHHHHHHHCT.ESEEEE-SHHHHHTTHHHHHHHHH..T- CS
      GARS_N   2 kvLvvGsGGRehala.wklaqspkvekvyvapgNagt...................edlealvefakeek.idlvvvGpeapLvaGvadaleeek..gi 77 
                 kvLvvG  GR  +l+  +l ++p+v+ v ++ + ++                    +++e+l + +++ + i  +v+G e+ +++G    le++k  g+
  EFC37868.1   5 KVLVVGATGRLGSLItSALLNKPTVQ-VSALIRKGSEtkaeqlkekgvqlisgalnDSVEDLQQACQNVDvIISAVIGSEDTIMDGQLRLLEAAKkaGV 102
                 8*********8776615778888887.4444433333379999998888888888655778999999988355789**********9999988766899 PP

                 EEES--CCCC CS
      GARS_N  78 kvfGpskeaA 87 
                 k f ps  +A
  EFC37868.1 103 KRFIPSDYSA 112
                 9999998776 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 8.1
                 -CGGTTHHHHHHHH CS
      GARS_N  34 Nagtedlealvefa 47 
                  +++edl++l+e+ 
  EFC37868.1 234 KGSVEDLKKLIETT 247
                 22224444555444 PP

>> DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   0.6   0.00034      0.35       1      81 [.       6      84 ..       6      98 .. 0.89
   2 ?    6.7   0.1     0.011        11      25      74 ..     202     252 ..     186     268 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00034
                     EEEESTTSHHHHHHHHHHHHCTTTEEEEEEEESSTHHHHHHHHHHHT-SEEEESSHHHHHHHHHHHHHTTSSSEEEESHHH CS
  DXP_reductoisom  1 vviLGsTGSIGtqtLdvieenpdkfevvalaagsnvellaeqakefkpklvavadeeaaeelkealkekelktevlvGeea 81
                     v+++G+TG +G+   + + ++p + +v+al  +   e+ aeq+ke  ++l++ a ++++e+l++a+++ ++ ++ ++G+e 
       EFC37868.1  6 VLVVGATGRLGSLITSALLNKP-TVQVSALIRKG-SETKAEQLKEKGVQLISGALNDSVEDLQQACQNVDVIISAVIGSED 84
                     689********99888888888.89****98744.677899*************************999999999999886 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.011
                      EEEEEEEE.SSTHHHHHHHHHHHT-SEEEESSHHHHHHHHHHHHHTTSSSE CS
  DXP_reductoisom  25 fevvalaa.gsnvellaeqakefkpklvavadeeaaeelkealkekelkte 74 
                       ++v++++   + ++la+q+++++ + ++++++ ++e+lk+ +++++ +t+
       EFC37868.1 202 NKIVSVSGdRVSYTQLAQQIEQVTGHKITLERKGSVEDLKKLIETTKNTTH 252
                      468888886678899**************************9987555443 PP

>> Ldh_1_N  lactate/malate dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.5   2.4e-05     0.026       1      74 [.       4      76 ..       4      92 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.4e-05
                EEEEEETTTSHHHHHHHHHHHHTTSSSEEEEE-SSHHHHHHHHHHHHHCHCCSTS-EEEEESSGGGGTTESEEE CS
     Ldh_1_N  1 vkvavvGaaGgiGqslalllankkladelaLlDiakekleGvaldlshistflsvkvkvsekeeealkdadvvv 74
                +kv vvGa+G  G+ +  +l+nk+ ++  aL+    ++++++ l  + +++++ +   + e+ ++a++++dv++
  EFC37868.1  4 TKVLVVGATGRLGSLITSALLNKPTVQVSALIRKG-SETKAEQLKEKGVQLISGALNDSVEDLQQACQNVDVII 76
                69*********************999977776544.355555555555555555555666699********986 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.5   4.2e-05     0.045       3      85 ..       6      79 ..       4     103 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 4.2e-05
                EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EE CS
          KR  3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGv 85
                +l++G++G LG  ++  l++k   ++  l R++     s+++ ++l+++g++    a+     d+ve l +++++ +  i+ v
  EFC37868.1  6 VLVVGATGRLGSLITSALLNKPTVQVSALIRKG-----SETKAEQLKEKGVQLISGALN----DSVEDLQQACQNVDVIISAV 79
                79******************************4.....344557788888876655544....33444444443333444555 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.2    0.0016       1.7       1      44 [.       6      51 ..       6      83 .. 0.72
   2 ?   -0.9   0.0      0.65   6.9e+02     103     124 ..      85     106 ..      66     113 .. 0.77
   3 ?    3.4   0.0     0.034        36     205     252 ..     183     230 ..     181     248 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0016
                     EEEETTTSHHHHHHHHHHHHHB-SEE..EEEES-HHHHHHHHHH.. CS
  Polysacc_synt_2  1 vlvtGagGsiGselvrqilkkkpkki..illerdElklyeiekele 44
                     vlv Ga+G +Gs +++ +l+k   ++  ++ + +E+k  +++++  
       EFC37868.1  6 VLVVGATGRLGSLITSALLNKPTVQVsaLIRKGSETKAEQLKEKGV 51
                     89*****************995555421566778999999988743 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.65
                      HHHHHHHHHHHHHHHTT-SEEE CS
  Polysacc_synt_2 103 tNvlgtenvieaaieagvkkvv 124
                      t + g   ++eaa++agvk+++
       EFC37868.1  85 TIMDGQLRLLEAAKKAGVKRFI 106
                      5566889999*********998 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.034
                      -HHHHHHHHHHHHHH--SS-EEEE--.-EEEHHHHHHHH......... CS
  Polysacc_synt_2 205 tieeavqLvlqalalakggeifvldmGepvkivdlakalielsgleek 252
                      t e+a++ v++a+   ++ +  v   G+ v+ ++la+++ +++g++ +
       EFC37868.1 183 TYEDAAKYVVEAALDPEQLNKIVSVSGDRVSYTQLAQQIEQVTGHKIT 230
                      56899999**9999999999999999************9999987765 PP

>> Peptidase_M4_C  Thermolysin metallopeptidase, alpha-helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.9   0.00053      0.56     107     147 ..     157     197 ..      52     208 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00053
  Peptidase_M4_C 107 kvtgigiekaakiyyraltkyltsttdFaeartaviqaAkd 147
                      + +i  +k  ki y    ++l  tt++++a++ v++aA d
      EFC37868.1 157 PFLNIIDTKNHKITYYGSADTLVDTTTYEDAAKYVVEAALD 197
                     45566678999***************************976 PP

>> DUF211  Uncharacterized ArCR, COG1888
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.42   4.4e+02      32      52 ..      57      77 ..      36      88 .. 0.72
   2 ?    9.8   0.2   0.00084      0.89      11      70 ..     165     226 ..     159     247 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.42
                EEEEEEEEE-SSEEEEEEEEE CS
      DUF211 32 gvnitvkevDketenlkitie 52
                + n +v ++ +  +n++++i 
  EFC37868.1 57 ALNDSVEDLQQACQNVDVIIS 77
                567788888888888888775 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00084
                 EESSS-HHHHHHHHHTSTTEEEEEEEEEE..E-SSEEEEEEEEEESSE-HHHHHHHHHCTT- CS
      DUF211  11 kphepsivelakklaelegvdgvnitvke..vDketenlkitieGenidyeeieeaieelgg 70 
                 k h+++    a++l ++++ + +   v+e  +D e  n  + + G++++y ++ ++ie++ g
  EFC37868.1 165 KNHKITYYGSADTLVDTTTYEDAAKYVVEaaLDPEQLNKIVSVSGDRVSYTQLAQQIEQVTG 226
                 5577888888888888888876666666534799999999******************9977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       969  (0.0540465); expected 358.6 (0.02)
Passed bias filter:                      627  (0.0349713); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 1895.21
//
Query:       EFC37869.1  [L=497]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-61  204.0  44.2    2.2e-08   34.5   0.5    9.2  9  Sel1      Sel1 repeat
      1e-05   26.0   9.9       0.58   10.9   0.2    5.6  6  TPR_16    Tetratricopeptide repeat
    1.2e-05   25.0   8.2       0.58   10.3   0.1    5.6  6  TPR_7     Tetratricopeptide repeat
     0.0019   18.2   0.8     0.0019   18.2   0.8    7.6  9  TPR_2     Tetratricopeptide repeat
      0.003   17.8  11.4       0.48   10.8   0.0    4.9  4  TPR_12    Tetratricopeptide repeat
     0.0073   16.1   0.9     0.0073   16.1   0.9    8.2 11  TPR_1     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.014   15.5  18.2      0.096   12.8   0.6    5.0  5  MIT       MIT (microtubule interacting and transport) domain
      0.022   15.6   2.9        3.1    8.9   0.0    4.3  4  TPR_14    Tetratricopeptide repeat
      0.024   15.3  20.1       0.57   10.9   0.1    7.2  8  TPR_6     Tetratricopeptide repeat
       0.39   11.0   2.6       0.98    9.7   2.6    1.6  1  CEBP_ZZ   Cytoplasmic polyadenylation element-binding protein
       0.55   10.7   4.0        3.9    8.0   0.2    3.4  4  PatG_D    PatG Domain
       0.65    9.2   7.2        7.2    5.8   0.1    3.3  4  DUF512    Protein of unknown function (DUF512)
       0.79    9.6   4.2          2    8.3   4.2    1.7  1  ZZ        Zinc finger, ZZ type
        3.2    8.3  13.8        4.8    7.8   0.1    5.4  6  TPR_17    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.1   6.4e-07   0.00082      21      38 .]      24      43 ..      15      43 .. 0.83
   2 !   27.6   1.7   2.6e-09   3.3e-06       1      38 []      44      79 ..      44      79 .. 0.95
   3 !   34.5   0.5   1.7e-11   2.2e-08       3      37 ..      82     114 ..      81     115 .. 0.93
   4 !   30.0   1.4   4.6e-10   5.9e-07       1      34 [.     116     147 ..     116     150 .. 0.90
   5 !   29.3   0.1   7.5e-10   9.6e-07       1      38 []     156     191 ..     156     191 .. 0.94
   6 !   18.6   1.7   1.7e-06    0.0022       2      38 .]     231     262 ..     230     262 .. 0.93
   7 !   34.3   0.1     2e-11   2.5e-08       1      36 [.     263     296 ..     263     298 .. 0.94
   8 !   34.3   0.2     2e-11   2.5e-08       1      38 []     299     334 ..     299     334 .. 0.95
   9 ?    0.8   0.0      0.71   9.1e+02       7      29 ..     341     361 ..     340     363 .. 0.72

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 6.4e-07
        Sel1 21 k..DpekAiewyekAAeqGd 38
                +  D+ kA+ewy kAAe+G+
  EFC37869.1 24 RegDYVKAMEWYLKAAEKGH 43
                345****************9 PP

  == domain 2  score: 27.6 bits;  conditional E-value: 2.6e-09
        Sel1  1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                a+A y+ + fy  ++G gv++D++kA+ew  kAAe+Gd
  EFC37869.1 44 AAAHYNIAGFY--HEGMGVKQDYSKAMEWNLKAAEKGD 79
                68******888..***********************97 PP

  == domain 3  score: 34.5 bits;  conditional E-value: 1.7e-11
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 A+++ G  y+y nG gv+k++ kA+ewy kA e++
  EFC37869.1  82 ALFNIG--YMYSNGEGVKKNYAKAMEWYLKADEHN 114
                 89****..999********************8886 PP

  == domain 4  score: 30.0 bits;  conditional E-value: 4.6e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAA 34 
                 a+A+++ +  ++y++G+gv kD  kA+ewy k+A
  EFC37869.1 116 ADAQHNIA--QFYYYGQGVQKDNAKAMEWYLKSA 147
                 68******..666*******************99 PP

  == domain 5  score: 29.3 bits;  conditional E-value: 7.5e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 ++A y+ G   +y nG gvp D +kA++w+  AA+ G+
  EFC37869.1 156 SAAKYNIG--SMYANGEGVPCDMSKAFRWFSTAAKEGH 191
                 6799****..777************************8 PP

  == domain 6  score: 18.6 bits;  conditional E-value: 1.7e-06
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  A+y ++   l+lnG    + + +A+ewy kAA+q++
  EFC37869.1 231 NAQYEVA--DLFLNG---MQSEYQALEWYLKAAKQDH 262
                 69*****..988***...799**************98 PP

  == domain 7  score: 34.3 bits;  conditional E-value: 2e-11
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeq 36 
                 a A+y +G   +y++G+g+ kD ++A+ew+ k+A+q
  EFC37869.1 263 APAQYEVG--NCYFFGRGTSKDLSSALEWFLKSADQ 296
                 57******..999**********************9 PP

  == domain 8  score: 34.3 bits;  conditional E-value: 2e-11
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 + A+ ++G  yl++nG  v+k+ ekA+e+y+kAAe+Gd
  EFC37869.1 299 PKALLMMG--YLFENGVEVEKNFEKALEYYKKAAEKGD 334
                 57999***..******99******************97 PP

  == domain 9  score: 0.8 bits;  conditional E-value: 0.71
        Sel1   7 LGmfylylnGlgvpkDpekAiew 29 
                 L+  ++y +G+g+ +     ++w
  EFC37869.1 341 LA--LMYSEGKGTTASMMDSLKW 361
                 89..677****988765555555 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.3   0.00079         1       3      63 ..      18      77 ..      16      80 .. 0.77
   2 ?    2.9   0.0      0.14   1.8e+02      47      66 ..      97     116 ..      82     119 .. 0.76
   3 ?   -0.9   0.0       2.2   2.8e+03      47      63 ..     133     149 ..     130     166 .. 0.82
   4 ?   -2.1   0.1         5   6.4e+03      33      45 ..     229     241 ..     221     243 .. 0.73
   5 !   10.9   0.2   0.00045      0.58      19      65 ..     250     299 ..     249     302 .. 0.86
   6 ?    3.0   0.0      0.13   1.6e+02      11      42 ..     317     343 ..     308     350 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00079
      TPR_16  3 laraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrq....grlaeAaalyraalra 63
                l++ + r gdy +A + +  a +++     +a+A+++ +  + +     +++ +A ++ ++a++ 
  EFC37869.1 18 LGTKYEREGDYVKAMEWYLKAAEKG-----HAAAHYNIAGFYHEGmgvkQDYSKAMEWNLKAAEK 77
                6666777777777775555555555.....**********9999999999999999999999865 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.14
      TPR_16  47 qgrlaeAaalyraalraapd 66 
                 ++++a+A ++y++a ++ + 
  EFC37869.1  97 KKNYAKAMEWYLKADEHNSA 116
                 499**********9877665 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 2.2
      TPR_16  47 qgrlaeAaalyraalra 63 
                 q++ a+A ++y++ +++
  EFC37869.1 133 QKDNAKAMEWYLKSAGN 149
                 77888888888887765 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 5
      TPR_16  33 aaeAllllgdaal 45 
                 +a A+++ +d++l
  EFC37869.1 229 DANAQYEVADLFL 241
                 7889999999876 PP

  == domain 5  score: 10.9 bits;  conditional E-value: 0.00045
      TPR_16  19 aleaalkrdpssPdaaeAllllgdaal.rq...grlaeAaalyraal.raap 65 
                 ale++lk+++   d+a A+++ g++++  +   ++l  A++++++ + +++p
  EFC37869.1 250 ALEWYLKAAK--QDHAPAQYEVGNCYFfGRgtsKDLSSALEWFLKSAdQEYP 299
                 7899*****8..88*************7668999999999999998866666 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.13
      TPR_16  11 gdyddAaaaleaalkrdpssPdaaeAllllgd 42 
                 +++++A+++++ a +++     + +  + l++
  EFC37869.1 317 KNFEKALEYYKKAAEKG-----DNQVKFTLAL 343
                 57888888888888877.....5555555555 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.1   0.00045      0.58       2      27 ..      15      38 ..      15      43 .. 0.88
   2 ?    2.0   0.0      0.21   2.7e+02       1      27 [.      46      74 ..      46      80 .. 0.83
   3 ?    2.5   0.0      0.14   1.8e+02       1      24 [.      82     109 ..      82     110 .. 0.90
   4 ?   -2.9   0.0       7.7   9.8e+03      12      24 ..     133     145 ..     120     152 .. 0.64
   5 ?   -0.3   0.1       1.1   1.4e+03       7      24 ..     238     257 ..     235     263 .. 0.79
   6 !    9.6   0.0   0.00076      0.98       2      32 ..     302     334 ..     301     348 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00045
       TPR_7  2 LlnLarlysrlGdyeeAielyeqsLa 27
                L+nL+  y+r+Gdy +A e y +  a
  EFC37869.1 15 LFNLGTKYEREGDYVKAMEWYLK--A 38
                7899999**************99..4 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.21
       TPR_7  1 aLlnLarlysr....lGdyeeAielyeqsLa 27
                a++n+a  y++     +dy++A e + +  a
  EFC37869.1 46 AHYNIAGFYHEgmgvKQDYSKAMEWNLK--A 74
                6789999999999999*******99888..4 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.14
       TPR_7   1 aLlnLarlysr....lGdyeeAielyeq 24 
                 aL+n++ +ys+      +y++A e y +
  EFC37869.1  82 ALFNIGYMYSNgegvKKNYAKAMEWYLK 109
                 7999******999999999999999987 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 7.7
       TPR_7  12 lGdyeeAielyeq 24 
                 + d ++A e y +
  EFC37869.1 133 QKDNAKAMEWYLK 145
                 4466778888876 PP

  == domain 5  score: -0.3 bits;  conditional E-value: 1.1
       TPR_7   7 rlysr..lGdyeeAielyeq 24 
                 +l+ +  + +y+ +++++++
  EFC37869.1 238 DLFLNgmQSEYQALEWYLKA 257
                 56666668999999999998 PP

  == domain 6  score: 9.6 bits;  conditional E-value: 0.00076
       TPR_7   2 LlnLarlysr....lGdyeeAielyeqsLaltkdp 32 
                 Ll ++ l+++    + ++e+A+e+y++  a +k +
  EFC37869.1 302 LLMMGYLFENgvevEKNFEKALEYYKK--AAEKGD 334
                 66666666666666779**********..766655 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.8   1.5e-06    0.0019       1      29 [.      12      40 ..      12      41 .. 0.93
   2 ?   -1.8   0.1       3.8   4.8e+03       3      11 ..      82      90 ..      81      94 .. 0.85
   3 ?    4.8   0.1     0.028        36      14      27 ..      97     110 ..      95     111 .. 0.93
   4 ?   -2.0   0.2       4.2   5.4e+03       1      13 [.     116     128 ..     116     130 .. 0.86
   5 ?   -0.7   0.0       1.6   2.1e+03      14      27 ..     133     146 ..     132     147 .. 0.86
   6 ?    1.0   0.2      0.47   6.1e+02      19      31 ..     249     261 ..     248     262 .. 0.88
   7 ?   -2.5   0.0       6.1   7.8e+03       2      12 ..     264     274 ..     263     274 .. 0.83
   8 ?   -1.5   0.0         3   3.9e+03      15      28 ..     281     294 ..     280     297 .. 0.82
   9 !   10.8   0.8   0.00035      0.45      15      29 ..     317     331 ..     314     335 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 1.5e-06
       TPR_2  1 aealynlGlayyklgdyeeAleafekAle 29
                a+ l+nlG  y++ gdy +A e++ kA e
  EFC37869.1 12 AKNLFNLGTKYEREGDYVKAMEWYLKAAE 40
                5679***********************87 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 3.8
       TPR_2  3 alynlGlay 11
                al+n+G+ y
  EFC37869.1 82 ALFNIGYMY 90
                89****999 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.028
       TPR_2  14 lgdyeeAleafekA 27 
                 +++y++A e++ kA
  EFC37869.1  97 KKNYAKAMEWYLKA 110
                 58**********98 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 4.2
       TPR_2   1 aealynlGlayyk 13 
                 a+a +n+++ yy+
  EFC37869.1 116 ADAQHNIAQFYYY 128
                 6899999*99997 PP

  == domain 5  score: -0.7 bits;  conditional E-value: 1.6
       TPR_2  14 lgdyeeAleafekA 27 
                 ++d ++A e++ k+
  EFC37869.1 133 QKDNAKAMEWYLKS 146
                 78999******985 PP

  == domain 6  score: 1.0 bits;  conditional E-value: 0.47
       TPR_2  19 eAleafekAleld 31 
                 +Ale++ kA + d
  EFC37869.1 249 QALEWYLKAAKQD 261
                 69*******9876 PP

  == domain 7  score: -2.5 bits;  conditional E-value: 6.1
       TPR_2   2 ealynlGlayy 12 
                  a y+ G++y+
  EFC37869.1 264 PAQYEVGNCYF 274
                 588999***97 PP

  == domain 8  score: -1.5 bits;  conditional E-value: 3
       TPR_2  15 gdyeeAleafekAl 28 
                 +d+  Ale+f k+ 
  EFC37869.1 281 KDLSSALEWFLKSA 294
                 68889*****9975 PP

  == domain 9  score: 10.8 bits;  conditional E-value: 0.00035
       TPR_2  15 gdyeeAleafekAle 29 
                 +++e+Ale+++kA e
  EFC37869.1 317 KNFEKALEYYKKAAE 331
                 89***********98 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.0   0.00037      0.48      40      72 ..       7      39 ..       2      40 .. 0.86
   2 ?    5.8   0.5     0.014        17      24      56 ..      98     127 ..      97     147 .. 0.84
   3 ?   -0.9   0.2       1.7   2.1e+03      16      31 ..     244     259 ..     229     274 .. 0.66
   4 ?    5.0   0.1     0.023        29      17      31 ..     317     331 ..     315     335 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00037
      TPR_12 40 dhpltattlrnLgrlyralgryeeAlelleeal 72
                +  + a  l+nLg+ y++ g+y +A e++ +a 
  EFC37869.1  7 QQNDDAKNLFNLGTKYEREGDYVKAMEWYLKAA 39
                55678999*********************9985 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.014
      TPR_12  24 ellekaleiarrllGpdhpltattlrnLgrlyr 56 
                 +++ ka+e + ++  ++h + a +++n+++ y+
  EFC37869.1  98 KNYAKAMEWYLKA--DEH-NSADAQHNIAQFYY 127
                 6899******888..888.99********9975 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 1.7
      TPR_12  16 lgrydeAlellekale 31 
                 ++   +Ale++ ka  
  EFC37869.1 244 MQSEYQALEWYLKAAK 259
                 6666788888888865 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.023
      TPR_12  17 grydeAlellekale 31 
                 +++++Ale+++ka e
  EFC37869.1 317 KNFEKALEYYKKAAE 331
                 567777777777755 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.9   5.7e-06    0.0073       4      29 ..      15      40 ..      12      41 .. 0.91
   2 ?   -1.7   0.2       2.3     3e+03       1       9 [.      44      52 ..      44      56 .. 0.78
   3 ?   -1.7   0.1       2.4     3e+03      15      27 ..      62      74 ..      61      76 .. 0.64
   4 ?   -0.2   0.1      0.78   9.9e+02       3      12 ..      82      91 ..      81      94 .. 0.89
   5 ?    4.2   0.2     0.033        43      14      27 ..      97     110 ..      95     114 .. 0.93
   6 ?   -3.0   0.2       6.2   7.9e+03       1      12 [.     116     127 ..     116     128 .. 0.85
   7 ?   -1.9   0.0       2.8   3.6e+03      14      26 ..     133     145 ..     132     146 .. 0.85
   8 ?   -1.3   0.1       1.8   2.3e+03       3      12 ..     158     167 ..     156     168 .. 0.83
   9 ?    0.4   0.2      0.52   6.7e+02      19      31 ..     249     261 ..     248     262 .. 0.86
  10 ?   -0.5   0.0         1   1.3e+03       1      12 [.     263     274 ..     263     275 .. 0.85
  11 !   11.8   1.7   0.00013      0.17      15      29 ..     317     331 ..     315     332 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 5.7e-06
                HHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1  4 lynlGnayfklgkydeAleyyekALe 29
                l+nlG  y + g+y +A e y kA e
  EFC37869.1 15 LFNLGTKYEREGDYVKAMEWYLKAAE 40
                89*********************965 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 2.3
                HHHHHHHHH CS
       TPR_1  1 akalynlGn 9 
                a a+yn++ 
  EFC37869.1 44 AAAHYNIAG 52
                789***985 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 2.4
                T-HHHHHHHHHHH CS
       TPR_1 15 gkydeAleyyekA 27
                ++y +A e   kA
  EFC37869.1 62 QDYSKAMEWNLKA 74
                5777777765555 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.78
                HHHHHHHHHH CS
       TPR_1  3 alynlGnayf 12
                al+n+G++y 
  EFC37869.1 82 ALFNIGYMYS 91
                89******96 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.033
                 TT-HHHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyekA 27 
                 +++y +A e y kA
  EFC37869.1  97 KKNYAKAMEWYLKA 110
                 58*********998 PP

  == domain 6  score: -3.0 bits;  conditional E-value: 6.2
                 HHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayf 12 
                 a+a  n+++ y+
  EFC37869.1 116 ADAQHNIAQFYY 127
                 789999999998 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 2.8
                 TT-HHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyek 26 
                 +++  +A e y k
  EFC37869.1 133 QKDNAKAMEWYLK 145
                 78899****9977 PP

  == domain 8  score: -1.3 bits;  conditional E-value: 1.8
                 HHHHHHHHHH CS
       TPR_1   3 alynlGnayf 12 
                 a yn+G +y 
  EFC37869.1 158 AKYNIGSMYA 167
                 78*****996 PP

  == domain 9  score: 0.4 bits;  conditional E-value: 0.52
                 HHHHHHHHHHHHS CS
       TPR_1  19 eAleyyekALeln 31 
                 +Ale y kA + +
  EFC37869.1 249 QALEWYLKAAKQD 261
                 7********8876 PP

  == domain 10  score: -0.5 bits;  conditional E-value: 1
                 HHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayf 12 
                 a a y  Gn+yf
  EFC37869.1 263 APAQYEVGNCYF 274
                 5688999****8 PP

  == domain 11  score: 11.8 bits;  conditional E-value: 0.00013
                 T-HHHHHHHHHHHHH CS
       TPR_1  15 gkydeAleyyekALe 29 
                 +++++Aleyy+kA e
  EFC37869.1 317 KNFEKALEYYKKAAE 331
                 89***********65 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.6   7.5e-05     0.096       2      32 ..      10      40 ..      10      47 .. 0.93
   2 ?    3.1   0.2     0.081     1e+02      17      30 ..      97     110 ..      94     113 .. 0.88
   3 ?   -2.6   0.0       4.6   5.9e+03      12      25 ..     132     141 ..     129     148 .. 0.60
   4 ?   -3.2   0.2       7.4   9.5e+03      23      31 ..     250     258 ..     248     263 .. 0.49
   5 ?    9.5   0.6   0.00077      0.99      16      32 ..     315     331 ..     313     332 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.5e-05
         MIT  2 dkAlelvkkAveeDnagnyeeAlelYkeale 32
                d A +l++  ++++++g+y +A+e+Y +a e
  EFC37869.1 10 DDAKNLFNLGTKYEREGDYVKAMEWYLKAAE 40
                5799************************987 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.081
         MIT  17 agnyeeAlelYkea 30 
                 ++ny++A+e+Y +a
  EFC37869.1  97 KKNYAKAMEWYLKA 110
                 79*********988 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 4.6
         MIT  12 veeDnagnyeeAle 25 
                 v++Dna+    A+e
  EFC37869.1 132 VQKDNAK----AME 141
                 6666655....555 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 7.4
         MIT  23 AlelYkeal 31 
                 Ale+Y +a 
  EFC37869.1 250 ALEWYLKAA 258
                 455554443 PP

  == domain 5  score: 9.5 bits;  conditional E-value: 0.00077
         MIT  16 nagnyeeAlelYkeale 32 
                  ++n+e+Ale+Yk+a e
  EFC37869.1 315 VEKNFEKALEYYKKAAE 331
                 689************87 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0      0.19   2.4e+02      11      33 ..      22      42 ..      13      51 .. 0.78
   2 ?   -0.6   0.0       2.5   3.3e+03      16      35 ..      99     118 ..      96     127 .. 0.73
   3 ?   -0.8   0.2       3.1   3.9e+03      19      34 ..     249     261 ..     230     269 .. 0.46
   4 ?    8.9   0.0    0.0024       3.1       1      42 [.     299     344 ..     299     346 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.19
      TPR_14 11 llalGdpdeAiallrralalaPd 33
                +++ Gd+ +A++ + +a ++  +
  EFC37869.1 22 YEREGDYVKAMEWYLKAAEK--G 42
                899*********99988664..4 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 2.5
      TPR_14  16 dpdeAiallrralalaPdda 35 
                 ++++A++ + +a +++ +da
  EFC37869.1  99 NYAKAMEWYLKADEHNSADA 118
                 78899999999877766655 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 3.1
      TPR_14  19 eAiallrralalaPdd 34 
                 +A++ + +a ++   d
  EFC37869.1 249 QALEWYLKAAKQ---D 261
                 444444444343...2 PP

  == domain 4  score: 8.9 bits;  conditional E-value: 0.0024
      TPR_14   1 peallalaealla....lGdpdeAiallrralalaPddaeawllla 42 
                 p+all+++ ++++      ++++A++++++a +++ ++  + l+l+
  EFC37869.1 299 PKALLMMGYLFENgvevEKNFEKALEYYKKAAEKGDNQVKFTLALM 344
                 67889999999884444599*************9999988887775 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       3.5   4.4e+03       8      24 ..       1      17 [.       1      18 [. 0.82
   2 ?    1.7   0.1      0.39     5e+02       3      22 ..      15      35 ..      13      41 .. 0.81
   3 ?   -0.9   0.0       2.5   3.3e+03       2      21 ..      46      69 ..      45      69 .. 0.74
   4 ?    4.4   0.1     0.054        69       2      21 ..      82     105 ..      81     110 .. 0.87
   5 ?    3.5   0.2       0.1   1.3e+02       1      21 [.     117     139 ..     117     146 .. 0.83
   6 ?   -1.2   0.4       3.3   4.3e+03       2      23 ..     232     255 ..     231     262 .. 0.74
   7 ?    3.8   0.0     0.085   1.1e+02       2      32 ..     265     300 ..     264     301 .. 0.90
   8 ?   10.9   0.1   0.00045      0.57       2      28 ..     301     331 ..     300     332 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 3.5
                HHHHHHHHHHHHHHHHH CS
       TPR_6  8 lsyrklgdtdkAleale 24
                +s+ ++++ d+A+ +++
  EFC37869.1  1 MSQPEGQQNDDAKNLFN 17
                5778867******9985 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.39
                HHHHHHHHHHHHHHHHHHH.H CS
       TPR_6  3 lyklalsyrklgdtdkAle.a 22
                l++l+  y++ gd+ kA+e +
  EFC37869.1 15 LFNLGTKYEREGDYVKAMEwY 35
                788998899989*****9854 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 2.5
                HHHHHHHHHHHH....HHHHHHHH CS
       TPR_6  2 Alyklalsyrkl....gdtdkAle 21
                A y++a  y ++    +d++kA+e
  EFC37869.1 46 AHYNIAGFYHEGmgvkQDYSKAME 69
                788888888884477778889876 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.054
                 HHHHHHHHHHHH....HHHHHHHH CS
       TPR_6   2 Alyklalsyrkl....gdtdkAle 21 
                 Al+++++ y ++    ++++kA+e
  EFC37869.1  82 ALFNIGYMYSNGegvkKNYAKAME 105
                 9**********8899999999998 PP

  == domain 5  score: 3.5 bits;  conditional E-value: 0.1
                 HHHHHHHHHHHH.HH.HHHHHHH CS
       TPR_6   1 dAlyklalsyrk.lg.dtdkAle 21 
                 dA+ ++a+ y+  +g ++d+A++
  EFC37869.1 117 DAQHNIAQFYYYgQGvQKDNAKA 139
                 7999*******988888887775 PP

  == domain 6  score: -1.2 bits;  conditional E-value: 3.3
                 HHHHHHHHHHH.HHHHH.HHHH.HH CS
       TPR_6   2 Alyklalsyrk.lgdtd.kAle.al 23 
                 A+y  a ++++ + +++ +Ale +l
  EFC37869.1 232 AQYEVADLFLNgM-QSEyQALEwYL 255
                 8999999999978.66668877555 PP

  == domain 7  score: 3.8 bits;  conditional E-value: 0.085
                 HHHHHHHHHHHH....HHHHHHHH.HHHHHHHH-TT CS
       TPR_6   2 Alyklalsyrkl....gdtdkAle.alerlikeYPd 32 
                 A+y  + +y+ +    +d + Ale  l++  +eYP+
  EFC37869.1 265 AQYEVGNCYFFGrgtsKDLSSALEwFLKSADQEYPK 300
                 89********98799999999999999999999997 PP

  == domain 8  score: 10.9 bits;  conditional E-value: 0.00045
                 HHHHHHHHHHHH....HHHHHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl....gdtdkAlealerlik 28 
                 Al++++++++++    ++ +kAle++++  +
  EFC37869.1 301 ALLMMGYLFENGveveKNFEKALEYYKKAAE 331
                 9**********9***************9876 PP

>> CEBP_ZZ  Cytoplasmic polyadenylation element-binding protein ZZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   2.6   0.00076      0.98       7      45 ..     405     443 ..     402     452 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00076
     CEBP_ZZ   7 PyledseCeiCekakargpyfCr..dlaCfkYyCetCwqrr 45 
                  +++ s C++Ce+  ++g y+ +  d++ f   C++Cw+++
  EFC37869.1 405 DFISKSICDVCEED-CEGFYYATgsDRNSFD-VCQKCWKKT 443
                 689999*****996.69***98722455555.8*****986 PP

>> PatG_D  PatG Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       2.9   3.7e+03      50      61 ..      27      38 ..       5      77 .. 0.58
   2 ?    8.0   0.2     0.003       3.9       8      63 ..      86     148 ..      80     151 .. 0.83
   3 ?   -1.6   0.0       2.8   3.5e+03      51      63 ..     247     259 ..     206     296 .. 0.63
   4 ?    1.7   0.0      0.27   3.4e+02      16      62 ..     321     366 ..     305     370 .. 0.57

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2.9
      PatG_D 50 ylaralsWiLti 61
                + ++a++W L++
  EFC37869.1 27 DYVKAMEWYLKA 38
                444444444443 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.003
      PatG_D   8 ieadFpn.earekefvqalar......aktanpedqqalakvLsnrenrylaralsWiLtieg 63 
                 i++ + n e+++k++ +a++       +++a +++++a + +  ++ +++ a+a++W L+  g
  EFC37869.1  86 IGYMYSNgEGVKKNYAKAMEWylkadeHNSADAQHNIAQFYYYGQGVQKDNAKAMEWYLKSAG 148
                 566665548999*******999998888888888999999999999***********998765 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 2.8
      PatG_D  51 laralsWiLtieg 63 
                 + +al+W L++ +
  EFC37869.1 247 EYQALEWYLKAAK 259
                 3445555555443 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.27
      PatG_D  16 arekefvqalaraktanpedqqalakvLsnrenrylaralsWiLtie 62 
                  + +++++a++++++  + + + +++  +    +++ ++l+W+L  +
  EFC37869.1 321 KALEYYKKAAEKGDNQVKFTLALMYSEGKG-TTASMMDSLKWLLDSY 366
                 234455555555555555555555544443.5558999999998765 PP

>> DUF512  Protein of unknown function (DUF512)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.9    0.0071         9      49      94 ..      31      79 ..      20     133 .. 0.78
   2 ?   -1.8   0.0       1.2   1.5e+03      50      61 ..     104     115 ..      94     163 .. 0.70
   3 ?   -1.4   0.0      0.95   1.2e+03      47      66 ..     248     267 ..     239     271 .. 0.74
   4 ?    5.8   0.1    0.0056       7.2      51     143 ..     288     389 ..     274     406 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0071
      DUF512 49 sDEfYllAerelPeeerYedfpqlenGVGmirlfleefeealeel...k 94
                + E+Yl+A ++   +++Y+    + +G G+ + + + +e +l+++    
  EFC37869.1 31 AMEWYLKAAEKGHAAAHYNIAGFYHEGMGVKQDYSKAMEWNLKAAekgD 79
                56******************99************999999998875541 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.2
      DUF512  50 DEfYllAerelP 61 
                  E+Yl+A+++  
  EFC37869.1 104 MEWYLKADEHNS 115
                 588888887633 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.95
      DUF512  47 flsDEfYllAerelPeeerY 66 
                 + + E+Yl+A ++    ++Y
  EFC37869.1 248 YQALEWYLKAAKQDHAPAQY 267
                 6778*****99875555555 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0056
      DUF512  51 EfYll.AerelPeeerYedfpqlenGVGmirlfleefeealeel.........krkvtivtGklaaellkelaekleekvkglkievvaikndfFGeti 139
                 E++l+ A++e P++    ++  +enGV + ++f++ +e   +++         +  +++  Gk +++ + + ++ l +++k+  ++   ++   + + +
  EFC37869.1 288 EWFLKsADQEYPKALLMMGYL-FENGVEVEKNFEKALEYYKKAAekgdnqvkfTLALMYSEGKGTTASMMDSLKWLLDSYKESMLSKSVVQFLQYFNLV 385
                 9999647899*********95.9***********99998877777788865554445555666666666666666666666666666666655555666 PP

      DUF512 140 tVaG 143
                 tV+G
  EFC37869.1 386 TVSG 389
                 6666 PP

>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   4.2    0.0015         2       5      43 ..     410     449 ..     408     451 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0015
                 EE-TTT-S..EESSEEEESSSSS.-EE-HHHHHH..H---S CS
          ZZ   5 ytCdgCseapligvRyhclrcsd.YDLCqsCfst.hkagkh 43 
                  +Cd+C e    g+ y   + ++ +D Cq+C ++ +  +++
  EFC37869.1 410 SICDVCEE-DCEGFYYATGSDRNsFDVCQKCWKKtKILKEF 449
                 58******.6679***99888877*******9987777766 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.1    0.0037       4.8      11      32 ..      10      31 ..       6      33 .. 0.90
   2 ?   -0.6   0.1       1.8   2.3e+03       2      24 ..      35      55 ..      34      80 .. 0.76
   3 ?   -0.7   0.1       1.9   2.5e+03      14      25 ..      81      92 ..      63     105 .. 0.71
   4 ?    5.2   0.6     0.025        33       9      29 ..     112     136 ..      99     141 .. 0.72
   5 ?   -2.4   0.0       6.8   8.7e+03       2      10 ..     254     262 ..     253     269 .. 0.85
   6 ?   -0.8   0.1       2.1   2.7e+03      12      24 ..     298     310 ..     290     329 .. 0.58

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0037
      TPR_17 11 nnadaynnLAelllknGdlmtA 32
                ++a+ ++nL++ +++ Gd+ +A
  EFC37869.1 10 DDAKNLFNLGTKYEREGDYVKA 31
                68*****************998 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.8
      TPR_17  2 ylkaleldPnnadaynnLAelll 24
                ylka+  ++ +a a++n A +++
  EFC37869.1 35 YLKAA--EKGHAAAHYNIAGFYH 55
                56666..6778888998887665 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 1.9
      TPR_17 14 daynnLAelllk 25
                 a++n ++ +++
  EFC37869.1 81 FALFNIGYMYSN 92
                589999999983 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.025
      TPR_17   9 dPnnadaynnLAelll....knGdl 29 
                 ++n+ada +n A++++     ++d 
  EFC37869.1 112 EHNSADAQHNIAQFYYygqgVQKDN 136
                 489**********997655533333 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 6.8
      TPR_17   2 ylkaleldP 10 
                 ylka+++d+
  EFC37869.1 254 YLKAAKQDH 262
                 999999985 PP

  == domain 6  score: -0.8 bits;  conditional E-value: 2.1
      TPR_17  12 nadaynnLAelll 24 
                 +++a+ ++++l++
  EFC37869.1 298 YPKALLMMGYLFE 310
                 5666666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (497 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       901  (0.0502538); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2919.48
//
Query:       EFC37870.1  [L=527]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.6e-16   59.0   0.1    7.7e-16   57.9   0.1    1.6  1  Acyltransferase  Acyltransferase
  ------ inclusion threshold ------
      0.046   13.4   0.0      0.078   12.7   0.0    1.3  1  OFeT_1           Ferrous iron uptake permease, iron-lead tran
       0.11   12.0   1.6       0.58    9.6   0.5    2.1  2  DUF3169          Protein of unknown function (DUF3169)
       0.14   11.8   0.3       0.21   11.2   0.3    1.3  1  Wzy_C            O-Antigen ligase
       0.17   11.4   0.9       0.44   10.2   0.2    2.0  2  Baculo_11_kDa    Baculovirus 11 kDa family


Domain annotation for each model (and alignments):
>> Acyltransferase  Acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.9   0.1   2.2e-19   7.7e-16       2     134 ..     249     371 ..     248     372 .. 0.88

  Alignments for each domain:
  == domain 1  score: 57.9 bits;  conditional E-value: 2.2e-19
  Acyltransferase   2 vrvtglenlpekgpailvaNHqsylDvlllwlllyksngprnvviiakkellsi.pllgflmrllgfifidRksnaraagslenisellee.gk 93 
                      ++++g   +++ ++ i+v+NH+s +D++ll++l         v ++++k+  ++  ++  +++ l+ i+++R + ++++++ ++i + ++  ++
       EFC37870.1 249 IKIHGIPPVRR-KNQIYVSNHTSLIDFILLTYLC-------GVATVGQKHGGFVgFMQDRVVSPLKNIWFERFESRDRKKTSQRIYDHINDvSN 334
                      67889888887.9*******************77.......6************777778999*********9999999999999995554145 PP

  Acyltransferase  94 l.vviFPEGtrsregellpfkkGlvrlaakakkgvpivPvai 134
                        ++iFPEG + +++++++fkkG++++     ++v i+P+ai
       EFC37870.1 335 PpLLIFPEGVCVNNEYIVMFKKGVFEI-----EDVEICPIAI 371
                      56*************************.....7899999998 PP

>> OFeT_1  Ferrous iron uptake permease, iron-lead transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   2.2e-05     0.078      53     102 ..     167     216 ..     154     229 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2.2e-05
      OFeT_1  53 tlGkyivllpldyvllvaavilfyfGyrllrsarryfkgikkkkkeeeee 102
                  +G+y +llpl  +l  ++ i f +   +l   r  f ++k++++e e++
  EFC37870.1 167 LIGRYCILLPLRILLFLSGTIAFILVTLILMVLRSIFEKKKNSQEETEQD 216
                 48******************999998888888888887777666444433 PP

>> DUF3169  Protein of unknown function (DUF3169)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.5   0.00016      0.58      57     123 ..     179     246 ..     159     254 .. 0.66
   2 ?    0.9   0.0     0.075   2.7e+02       3      32 ..     270     301 ..     268     312 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00016
     DUF3169  57 li......iavlvviisvvflrkakkllkkwdeeddeeseeeyeqiekklsiglilssvslilsfllilasys 123
                 ++      ia ++v + +++lr++ + +k+++ee ++++     q+ekk+++  +l++ sl  +  + + s+s
  EFC37870.1 179 ILlflsgtIAFILVTLILMVLRSIFEKKKNSQEETEQDQ-----QEEKKITTLDWLVRKSLQYYSAIWIHSMS 246
                 333435456666666668888999888888888888887.....77888888877777666555555555555 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.075
     DUF3169   3 allkfillmliggl..iGgiiGfllgafeaek 32 
                 +l+ fill+ ++g+  +G   G+++g+++++ 
  EFC37870.1 270 SLIDFILLTYLCGVatVGQKHGGFVGFMQDRV 301
                 68899999999986458*9********99983 PP

>> Wzy_C  O-Antigen ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.3   5.9e-05      0.21      20      80 ..     161     228 ..     157     326 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 5.9e-05
       Wzy_C  20 igllvalivlliifykrripfllllgilvgvilliilfvlstnletlknitkafgkldkk........k 80 
                 +g l+ali    i++  ri  l+l+g ++ +++ +il+vl + +e+ kn + + ++ +++         
  EFC37870.1 161 VGWLIALIGRYCILLPLRI-LLFLSGTIAFILVTLILMVLRSIFEKKKNSQEETEQDQQEekkittldW 228
                 4455566655555555555.7899999999999999999999999999987665554444555555554 PP

>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.2   0.00012      0.44      37      75 ..     180     218 ..     167     227 .. 0.83
   2 ?   -2.8   0.0       1.3   4.8e+03      24      42 ..     262     282 ..     261     284 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00012
  Baculo_11_kDa  37 vLvicglvvfvvivlfilLlvvilknaeaeeaekekrek 75 
                    +L ++g + f++++l +++l +i++++++++ e e+ ++
     EFC37870.1 180 LLFLSGTIAFILVTLILMVLRSIFEKKKNSQEETEQDQQ 218
                    78999******************9988877766655544 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.3
  Baculo_11_kDa  24 qlvsrNrsflrdFvLv..icg 42 
                    q+   N++ l dF+L+  +cg
     EFC37870.1 262 QIYVSNHTSLIDFILLtyLCG 282
                    555668888889998633555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (527 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1663  (0.0927548); expected 358.6 (0.02)
Passed bias filter:                      969  (0.0540465); expected 358.6 (0.02)
Passed Vit filter:                       114  (0.00635841); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.82u 0.38s 00:00:01.20 Elapsed: 00:00:00.55
# Mc/sec: 2870.38
//
Query:       EFC37871.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0069   16.0   3.7      0.014   15.0   3.7    1.4  1  Lin-8     Ras-mediated vulval-induction antagonist


Domain annotation for each model (and alignments):
>> Lin-8  Ras-mediated vulval-induction antagonist
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   3.7   7.8e-07     0.014     109     255 ..      46     189 ..      29     211 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 7.8e-07
       Lin-8 109 fYgfiryYRetlgkwEaelRkeaitgeaqkaddddiiyegyleaeegedteeeekveveeeaeeqgsmdlketeaeevkeeqmeqsfeeeeeakleept 207
                 +Y  i +Y+ +  ++   l +  i  +++ +++   + +   +++eg + ++e++++ ++ +++++++ ++  e +++++ +++++     +++l  +t
  EFC37871.1  46 MYDKITFYKHNNTELDLTLYNNIISTSSATSNN--TDGDANNNSKEGTQINDENNHTDNKPNKNDDEAVVEIIEGNQQQSVNTTSTNG-TSSENLVAET 141
                 699999999999999999999998866655533..33334445778889999999999999999999997777777777666666666.999999**** PP

       Lin-8 208 vniveeeaaaravdqsfgsaeqqlessssrtssassssssaapsstaa 255
                  niv+e +++++v+ ++ +     + ++s+ +s+++ss s  +s+t++
  EFC37871.1 142 PNIVAESSNNSKVKTPTDDVSTSVATTPSKEKSIPISSPSGVSSPTKK 189
                 *********************999**************9988888864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1435  (0.0800379); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 2901.33
//
Query:       EFC37872.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-10   39.7  21.0    3.9e-09   36.6  18.2    3.2  2  Leo1      Leo1-like protein
  ------ inclusion threshold ------
          7    7.3   9.6        5.4    7.7   0.3    3.6  4  Ig_3      Immunoglobulin domain


Domain annotation for each model (and alignments):
>> Leo1  Leo1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6  18.2   4.4e-13   3.9e-09      33     162 ..      99     257 ..       8     292 .. 0.78
   2 ?   -1.5   1.6      0.22     2e+03     144     151 ..     274     281 ..     256     339 .. 0.59

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 4.4e-13
        Leo1  33 e................................eserarkklkaentiRwRykedkgteikeSNArivrWsDGSlsLqlGse.vfdvtrkal.adsnty 97 
                 +                                  e+ +  +++  tiRw+++e  +t + eSN+r+v+ +DGS++ ++G+e +++++ k+  + +n +
  EFC37872.1  99 QvlevkhserptkdsldlfflrtpiqfntdekeFTEESSLPKNDLYTIRWKKNE--ETGEIESNTRVVQYEDGSYQVFVGNEvILNLEAKKYtNYNNLH 195
                 3444444444444555555555555555544334566677788889********..68************************88899888873445667 PP

        Leo1  98 LvvsheaeevleaqgvitekltfrPasleseahrrltravakrhkkkakktklivteeDpekeke 162
                 L+ +  +  ++  +g +t++l+ + +s++++  r ++ ++ k ++++ k +k++ t + pe e  
  EFC37872.1 196 LFEK-VSPFCYYGHGIFTHRLNSKATSTQTK-GRDIALKLTKGTTTT-KIKKTVLTSKRPETEET 257
                 7776.45556999999999999999999876.567888888886665.57777777777776654 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.22
        Leo1 144 kakktkli 151
                 k++k +++
  EFC37872.1 274 KQQKYQNT 281
                 22222222 PP

>> Ig_3  Immunoglobulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.6      0.35   3.1e+03      50      69 ..      28      52 ..      15      55 .. 0.57
   2 ?   -2.6   0.0      0.99   8.8e+03      19      41 ..      73      95 ..      64     116 .. 0.60
   3 ?    3.8   0.1      0.01        91      31      50 ..     141     164 ..     133     192 .. 0.59
   4 ?    7.7   0.3    0.0006       5.4      44      72 ..     266     294 ..     216     294 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.35
                E.....SSEECCCTEEEESS--GGG CS
        Ig_3 50 s.....issegssssLtisnvtksd 69
                +     +ss+++  ++t ++vt+s 
  EFC37872.1 28 QneeiqSSSDNEVEEFTHRRVTRSS 52
                1233335667777778888888775 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.99
                EEEEEEEEEES--EEEEEETTS. CS
        Ig_3 19 vtLtCeaegnppptitWykngek 41
                 +Lt +ae++++  +++  +g  
  EFC37872.1 73 QMLTSQAEHYDSLLYKYDSDGDD 95
                55666666666666666666653 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.01
                 -...EEEEEETTS.....TTCSEEE CS
        Ig_3  31 p...titWykngek..lssnstsss 50 
                 +   ti+W+kn+e+  ++s +t+  
  EFC37872.1 141 NdlyTIRWKKNEETgeIES-NTRVV 164
                 344599*******764222.23322 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.0006
                 TTCSEEESSEECCCTEEEESS--GGG-EE CS
        Ig_3  44 snstsssissegssssLtisnvtksdsGt 72 
                 s ++++++++++++++Lt++n++ +d+G+
  EFC37872.1 266 SLKKKQQKKQQKYQNTLTLDNASLEDAGS 294
                 333333378999***************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3291  (0.183557); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.81u 0.36s 00:00:01.17 Elapsed: 00:00:00.54
# Mc/sec: 1978.75
//
Query:       EFC37873.1  [L=249]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.7e-70  234.8   0.2    8.7e-70  234.7   0.2    1.0  1  EAP30     EAP30/Vps36 family
  ------ inclusion threshold ------
       0.32   11.2   3.6        1.1    9.4   1.0    2.2  2  CTNNBL    Catenin-beta-like, Arm-motif containing nuclear


Domain annotation for each model (and alignments):
>> EAP30  EAP30/Vps36 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  234.7   0.2   9.7e-74   8.7e-70       1     235 [.       5     231 ..       5     232 .. 0.95

  Alignments for each domain:
  == domain 1  score: 234.7 bits;  conditional E-value: 9.7e-74
       EAP30   1 vGiaglqrreqtaaeyqdlgaellaealqdleallakfkesLvklaekhkakiksdpafraqftkmcaslGvdpl.sskkseslgfl.ellglgdfyye 97 
                 vGi++lq  + ++++++++g+ +++ +++++++ l+ f++sL+++a khk++i+++++fr+qf++mc+++Gvdpl s+k     gf+ ellg+gdfyye
  EFC37873.1   5 VGIGALQADKLRQQKFKEKGEDVNNMQVSQMKERLDIFRQSLEEFAIKHKKDINKNAEFRHQFQQMCSKIGVDPLaSNK-----GFWaELLGVGDFYYE 98 
                 7**************************************************************************8888.....*************** PP

       EAP30  98 Lavqivevclatraengglisleelyalvnrarggv.a...lvspdDllraiekllvlgsglsvlqvg.gkkvvrSvptelntdqvevl..evakrlvs 189
                 L+ qi+e+cl+tr++nggli+l el ++v+++r++  +   ++++dD++r+i++l+vlg+g++++ vg g+++v+Svp e n+dq+++l   +ak++  
  EFC37873.1  99 LGIQIIEICLKTRNQNGGLIELNELTERVQKTRNKYsQkdyEITTDDIKRSIKHLKVLGNGFQLVMVGgGRYFVQSVPCEMNADQTSILssVLAKKA-- 195
                 *********************************98855999**************************9789**************999964444444.. PP

       EAP30 190 llaekssgggvtaselaeeeenlgwsvarakeaLeelereGllwvD 235
                         +g+t+s++   e++l ws++r+ +aL+ l++eG++w+D
  EFC37873.1 196 -------LEGMTVSDF---ERELMWSKERVVSALRPLIMEGFAWID 231
                 .......246******...778***********************9 PP

>> CTNNBL  Catenin-beta-like, Arm-motif containing nuclear
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   1.0   0.00012       1.1      13      51 ..      33      73 ..      19      75 .. 0.77
   2 ?    1.8   0.1      0.03   2.7e+02      29      69 ..     118     156 ..     108     162 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00012
      CTNNBL 13 eeeeekld..eaalkklllklekkvkknqelRikyeddpek 51
                ++ +e+ld   ++l + ++k +k ++kn+e R ++++  +k
  EFC37873.1 33 SQMKERLDifRQSLEEFAIKHKKDINKNAEFRHQFQQMCSK 73
                333555552269999********************998776 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.03
      CTNNBL  29 lklekkvkknqelRikyeddpekfmeSEadLdeeikelsvl 69 
                 ++l++ +++ q+ R ky+++         d++ +ik+l+vl
  EFC37873.1 118 IELNELTERVQKTRNKYSQKDYEI--TTDDIKRSIKHLKVL 156
                 677788889999999999875443..334677777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (249 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1416  (0.0789782); expected 358.6 (0.02)
Passed bias filter:                      780  (0.0435049); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 1479.95
//
Query:       EFC37874.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-05   25.1   0.0    3.2e-05   24.5   0.0    1.3  1  AAA_18          AAA domain
     0.0012   18.6   0.0     0.0037   17.0   0.0    1.6  2  Cytidylate_kin  Cytidylate kinase
     0.0033   17.6   0.0     0.0035   17.5   0.0    1.3  1  AAA_33          AAA domain
     0.0039   17.3   0.0      0.006   16.7   0.0    1.3  1  SKI             Shikimate kinase
  ------ inclusion threshold ------
      0.016   15.1   0.0      0.025   14.5   0.0    1.3  1  Rad17           Rad17 P-loop domain
      0.021   15.0   0.0      0.029   14.6   0.0    1.3  1  AAA_28          AAA domain
      0.023   14.0   0.0      0.036   13.3   0.0    1.2  1  Zeta_toxin      Zeta toxin
      0.041   13.6   0.0      0.058   13.1   0.0    1.2  1  CoaE            Dephospho-CoA kinase
       0.06   13.2   0.0       0.14   12.0   0.0    1.6  2  dNK             Deoxynucleoside kinase


Domain annotation for each model (and alignments):
>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.5   0.0   1.6e-08   3.2e-05       1      67 [.      47     107 ..      47     149 .. 0.64

  Alignments for each domain:
  == domain 1  score: 24.5 bits;  conditional E-value: 1.6e-08
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf.........gvnlrdvakenglllevdpealdeskrldedkldklldaleen 67 
                 I+l G++++GK+t +keLsk+l++          +   +  ++n                 + ++++++ + +++ 
  EFC37874.1  47 IILHGPCASGKSTHSKELSKSLNIpvidsdfhrFYPAHEFEWKNK---------------SRAEFVAAVEKDMDQY 107
                 99********************66655544444333333333333...............3333333333333333 PP

>> Cytidylate_kin  Cytidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   1.8e-06    0.0037       1      30 [.      47      76 ..      47      96 .. 0.88
   2 ?   -1.4   0.0      0.84   1.7e+03     109     136 ..     106     134 ..      85     138 .. 0.67

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.8e-06
                    EEEE-STTSSHHHHHHHHHHHHT-EEEEHH CS
  Cytidylate_kin  1 iaiDGPagsGKssvaralaeklglkyldtg 30
                    i + GP +sGKs+ +++l++ l++ ++d+ 
      EFC37874.1 47 IILHGPCASGKSTHSKELSKSLNIPVIDSD 76
                    5688***********************984 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.84
                     T-BSSBEEEEESSII.IIISTT-SEEEEE CS
  Cytidylate_kin 109 lvkkarvvveGRDig.tvvfpdaelKifl 136
                       ++++ v++GR +    v+ +a++ i +
      EFC37874.1 106 QYREKGWVFDGRVLQlPSVVREANVLIMM 134
                     33467889999987634677778776665 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   1.8e-06    0.0035       2      32 ..      47      77 ..      47     204 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.8e-06
      AAA_33  2 vllvGlpGsGKstlaerllkklgavllssdt 32
                ++l+G+ +sGKst +++l k l   +++sd 
  EFC37874.1 47 IILHGPCASGKSTHSKELSKSLNIPVIDSDF 77
                699**************************96 PP

>> SKI  Shikimate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0     3e-06     0.006       2      25 ..      54      77 ..      53     115 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 3e-06
                TSSHHHHHHHHHHHHTSEEEEHHH CS
         SKI  2 GaGKstvGkllAkklglefiDlDe 25
                ++GKst  k+l+k+l++++iD+D 
  EFC37874.1 54 ASGKSTHSKELSKSLNIPVIDSDF 77
                59*********************6 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   1.2e-05     0.025      38      75 ..      38      74 ..      30     109 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.2e-05
       Rad17 38 dvLesrkkriLLisGPsGCgkstvvkvLskelgiklre 75
                ++Les++ +i+L  GP   gkst  k+Lsk l i +++
  EFC37874.1 38 ESLESKPIKIIL-HGPCASGKSTHSKELSKSLNIPVID 74
                789999999865.8*****************9998775 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   1.4e-05     0.029       1      62 [.      46     107 ..      46     147 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.4e-05
      AAA_28   1 kivitGgestGKTtlleaLaar.gypvv.pEaareileeklakgedalpwvedllafaervlee 62 
                 ki++ G+  +GK+t +++L++  ++pv+  +++r +   + +++++++++ e + a+++ + + 
  EFC37874.1  46 KIILHGPCASGKSTHSKELSKSlNIPVIdSDFHRFYP-AHEFEWKNKSRA-EFVAAVEKDMDQY 107
                 799*****************988*****666666665.555666665665.3455555554444 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.8e-05     0.036      13      83 ..      41     107 ..      31     112 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.8e-05
  Zeta_toxin  13 qerPklillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPeyeeilkadpkkaseltqkdasel 83 
                 +++P+ i+l G  ++GKs+ +++l ++l    n+ ++d D  R +  +  e  ++  +++++ ++kd+ + 
  EFC37874.1  41 ESKPIKIILHGPCASGKSTHSKELSKSL----NIPVIDSDFHRFYPAHEFEWKNKSRAEFVAAVEKDMDQY 107
                 489************************9....788888875555444445667778888888888888765 PP

>> CoaE  Dephospho-CoA kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   2.9e-05     0.058       3      32 ..      47      77 ..      45      96 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.9e-05
                EEEEESTTSSHHHHHHHHHH.TT-EEEEHHH CS
        CoaE  3 vgltGgiasGKstvanlfad.lgvpivDaDl 32
                + l G  asGKst ++ +++ l++p++D D 
  EFC37874.1 47 IILHGPCASGKSTHSKELSKsLNIPVIDSDF 77
                568899************999********95 PP

>> dNK  Deoxynucleoside kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   7.2e-05      0.14       1      35 [.      47      81 ..      47     119 .. 0.77
   2 ?   -2.1   0.0       1.4   2.8e+03      25      39 ..     158     172 ..     149     198 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 7.2e-05
                EEEEESTTSSHHHHHHHHHCCSTCEEEE-HHHHCC CS
         dNK  1 ivveGnIgaGKstlvklLskklgvkvfeEpvdkwt 35
                i + G+ ++GKst  k Lsk l+++v+     ++ 
  EFC37874.1 47 IILHGPCASGKSTHSKELSKSLNIPVIDSDFHRFY 81
                6789********************99988666554 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.4
                 EEEE-HHHHCCSSSS CS
         dNK  25 kvfeEpvdkwtnvqk 39 
                 k+++  v++wtn+ +
  EFC37874.1 158 KCCNGNVERWTNQLG 172
                 445555555555433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1090  (0.0607954); expected 358.6 (0.02)
Passed bias filter:                      730  (0.0407162); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 1323.13
//
Query:       EFC37875.1  [L=789]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   4.9e-160  532.1   0.0   2.4e-153  510.1   0.0    2.4  2  Meth_synt_2  Cobalamin-independent synthase, Catalytic domain
   1.5e-120  402.5   0.0   4.9e-111  371.2   0.0    2.8  3  Meth_synt_1  Cobalamin-independent synthase, N-terminal domai


Domain annotation for each model (and alignments):
>> Meth_synt_2  Cobalamin-independent synthase, Catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   5.6e-08    0.0005     113     303 ..     156     347 ..     144     356 .. 0.76
   2 !  510.1   0.0  2.7e-157  2.4e-153       1     323 [.     457     779 ..     457     780 .. 1.00

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 5.6e-08
                  HHHTTS-SS-BEEEEE-HHHHHHTSEE-.....TTS-HHHHHHHHHHHHHHHHHHHHHTT-SEEEEE-TTSSTT--SSGGGHHHHHHHHHHHHHHHHT CS
  Meth_synt_2 113 alaqsltdkpvkglltGpvtilnwsfvr.....ddvdraeaaaqialalrdevkdLeaaGikviQiDepalreGlplkkadwaayldwaveafrldti 205
                     q+l    vk ++ Gp t l+ +  +      d ++ + + ++  +  + +++  + G+k  QiDep l   l +   +w + ++      +l+++
   EFC37875.1 156 EAEQVLGIDRVKPVIIGPLTWLYLAKGEefvgsLDSKKLTLLEKLLPVYNQVLQQFSQLGVKWTQIDEPVLCLDLND---EWRQAFQTFY--QQLNQS 248
                  5567788888999*********99988855555577888888889999999999***************99755544...4555554333..334444 PP

                  TS-TTSEEEEEES-S--CCCHHHHHTT--SEEEESBSSS-SSGGGGTTT.T---SEEEEBSS-TTSSS--THHHHHHHHHCHHCT...S-STSB-BB- CS
  Meth_synt_2 206 aaaddtqvhtHlCyselndilsaiaaldvDvitieasrsdeellealee.vkygrgvglGvydihsprvpsmeeiaalikkaldv...apkerlwvnP 299
                    + ++ ++t +   +l d+l+++ +l v +i i+a r +++l  +le  +++ + + +G++d         +   ++i+k++       + rlw +P
   EFC37875.1 249 -KKLNILIATYF--GNLLDNLKTLVNLPVEAIHIDAVRAPQQLAPVLESlKNSSKILSVGLIDGRNIWRSDLDACIETIQKVIIGefkFDASRLWLSP 343
                  .45566666665..6788999**********************9*****99999999******77663333344444444443334556699****** PP

                  SS-S CS
  Meth_synt_2 300 dCGL 303
                   C L
   EFC37875.1 344 SCSL 347
                  **88 PP

  == domain 2  score: 510.1 bits;  conditional E-value: 2.7e-157
                  S-BB--SB---SS-----------------HHHHHHHHHHHHHHHHHHTT--SCBE-B-TT-SSTTHHHHTTSTTEE--SS--EEEETTEEE---EE- CS
  Meth_synt_2   1 lpTttiGSfPqtaevrearaevkkgelseeeyekaireeiekvvrrqeelgvDvlvhgepeRgdmveyfgealdgfaftkngwvqsygsrcvrppiiv 98 
                  +pTttiGSfPqt+e+r++r ++k+g++s e yek+++eeiekvvr qee+g+DvlvhgepeR+dmveyfge ++g+aft+ngw qs+gsrcv+pp+i+
   EFC37875.1 457 FPTTTIGSFPQTQEIRSIRLKYKNGTVSRELYEKFMKEEIEKVVRLQEEIGLDVLVHGEPERNDMVEYFGELMNGYAFTENGWTQSFGSRCVKPPVIF 554
                  8************************************************************************************************* PP

                  SS---SS-SSTHHHHHHTTS-SS-BEEEEE-HHHHHHTSEE-TTS-HHHHHHHHHHHHHHHHHHHHHTT-SEEEEE-TTSSTT--SSGGGHHHHHHHH CS
  Meth_synt_2  99 gdvsrpaamtvkesalaqsltdkpvkglltGpvtilnwsfvrddvdraeaaaqialalrdevkdLeaaGikviQiDepalreGlplkkadwaayldwa 196
                  gd+s  ++mtv++s +aqsltdkp+kg+ltGpvtilnwsfvrdd++r+e+++q+al+lrdev +Le+aGik+iQiDepa+reGlpl+k+dw++yl+wa
   EFC37875.1 555 GDISLDKPMTVEWSSYAQSLTDKPMKGMLTGPVTILNWSFVRDDQPRSETCKQLALVLRDEVLNLEKAGIKIIQIDEPAVREGLPLRKSDWNTYLKWA 652
                  ************************************************************************************************** PP

                  HHHHHHHHTTS-TTSEEEEEES-S--CCCHHHHHTT--SEEEESBSSS-SSGGGGTTTT---SEEEEBSS-TTSSS--THHHHHHHHHCHHCTS-STS CS
  Meth_synt_2 197 veafrldtiaaaddtqvhtHlCyselndilsaiaaldvDvitieasrsdeellealeevkygrgvglGvydihsprvpsmeeiaalikkaldvapker 294
                  v+ f+l+t++++ dtq+htH+Cyse+ndi+++i a+d+Dvi+ie+srs++ell+a+e++ky++++g+Gvydihsp+vp +e++ +lik+a++++pke+
   EFC37875.1 653 VDCFKLTTSGVEIDTQIHTHMCYSEFNDIIDSIGAMDADVISIETSRSNMELLQAFEDFKYPNDIGPGVYDIHSPNVPNVEWMVKLIKNAIERIPKEN 750
                  ************************************************************************************************** PP

                  B-BB-SS-STTS-HHHHHHHHHHHHHHHH CS
  Meth_synt_2 295 lwvnPdCGLktrkreearaalknmvdaAk 323
                  +w+nPdCGLktr+++e+++al  mv+aA+
   EFC37875.1 751 IWINPDCGLKTRGYQEVKQALIAMVQAAQ 779
                  ****************************8 PP

>> Meth_synt_1  Cobalamin-independent synthase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  371.2   0.0  5.5e-115  4.9e-111       2     308 ..       8     327 ..       7     329 .. 0.95
   2 ?   -0.4   0.0     0.071   6.4e+02      13      59 ..     468     514 ..     459     522 .. 0.84
   3 !   27.5   0.0   2.4e-10   2.1e-06     148     280 ..     577     716 ..     556     742 .. 0.79

  Alignments for each domain:
  == domain 1  score: 371.2 bits;  conditional E-value: 5.5e-115
                  EB-S---SSTTTTHHHHHHHHHHTTSS-HHHHHHHHHHHHHHHHHHHHCTT.-SBEEES---SS-HHHHHHHHTT---GGGT...T.SSSSSHHHHHH CS
  Meth_synt_1   2 ssilGfPriGekRelkkalesywkgkiseeeLektakeLrakhwkkqkeag.idlipvndfslYDhvLdtavllgaiPerfk...leekkeeldtyFa 95 
                  +++lGfPriG++Relk+alesyw+ ki+ ++Le ++++Lr++hw++q +ag +dlipv+df++YD+vL++++++g iP+r++   ++++  +ldt+F+
   EFC37875.1   8 THNLGFPRIGARRELKQALESYWSCKIDLNALELVGTQLRKQHWEQQLQAGqLDLIPVGDFAWYDQVLEWTTTIGCIPKRHQsdsAQDQPFHLDTLFR 105
                  79*******************************************99887559*****************************7655566689****** PP

                  HHHSC....TTCT--EEEESTTSS-EEEE-BE-SS.----S-THHHHHHHHH.HHTTGG.EEEEEE-HHHHHHT-EETTCC.....-HCHHHHHHHHH CS
  Meth_synt_1  96 laRGk....kdvaalemtkwFntnYHYlvPelekdtefklaseklleevkea.kalgie.akpvllGpltflkLskakeek....veklellekLlpv 183
                  +aRG+    + +aa+emtkwF+tnYH++ Pe++ ++ef+l+++ l+e+vkea + lgi+ +kpv++Gplt+l+L+k +e       +kl+llekLlpv
   EFC37875.1 106 MARGRaptgQPAAACEMTKWFDTNYHFITPEIKLNQEFALSRTFLFEQVKEAeQVLGIDrVKPVIIGPLTWLYLAKGEEFVgsldSKKLTLLEKLLPV 203
                  *****9999999****************************************888999538***************99866555567888******** PP

                  HHHHHHHHHHTT-SEEEEE-GGGGSSGCHHHHHHHHHHHHHHTCCTTTSEEEEE--SS-.CCHHHHHTTSSTSEEEEETSSHCHHHHHHHHCTT.TTS CS
  Meth_synt_1 184 YkelleeLkeagvewvqidEPalvldlekeelealkeaYeelakekkelklllatyFdsvaealellaelpveglglDlvraeenlealkkaglpedk 281
                  Y+++l+++++ gv+w qidEP+l+ldl++e+++a++++Y++l +++k+l++l+atyF+++ ++l++l++lpve++++D vra+++l+ + +   +++k
   EFC37875.1 204 YNQVLQQFSQLGVKWTQIDEPVLCLDLNDEWRQAFQTFYQQL-NQSKKLNILIATYFGNLLDNLKTLVNLPVEAIHIDAVRAPQQLAPVLESLKNSSK 300
                  ******************************************.6999********************************************9999*** PP

                  EEEEEEE-SSS-B---HHHHHHHHHHH CS
  Meth_synt_1 282 vLsaGvidGrniWradlekalelleel 308
                  +Ls+G+idGrniWr+dl++ +e+++++
   EFC37875.1 301 ILSVGLIDGRNIWRSDLDACIETIQKV 327
                  ***********************9986 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.071
                  TTHHHHHHHHHHTTSS-HHHHHHHHHHHHHHHHHHHHCTT-SBEEES CS
  Meth_synt_1  13 kRelkkalesywkgkiseeeLektakeLrakhwkkqkeagidlipvn 59 
                    e++ +  +y +g++s+e  ek +ke  +k ++ q+e g+d+   +
   EFC37875.1 468 TQEIRSIRLKYKNGTVSRELYEKFMKEEIEKVVRLQEEIGLDVLVHG 514
                  568888888999******************************98765 PP

  == domain 3  score: 27.5 bits;  conditional E-value: 2.4e-10
                  GGEEEEEE-HHHHHHT-EETTCC.-HCHHHHHHHHHHHHHHHHHHHTT-SEEEEE-GGGGSSG...CHHHHHHHHHHHHHHT..CCTT..TSEEEEE- CS
  Meth_synt_1 148 ieakpvllGpltflkLskakeekveklellekLlpvYkelleeLkeagvewvqidEPalvldl...ekeelealkeaYeela..kekk..elklllat 238
                    +k +l Gp+t l  s  ++++  + e+ ++L  v ++ + +L++ag++++qidEPa+   l   ++++   lk a + ++  ++    ++++  ++
   EFC37875.1 577 KPMKGMLTGPVTILNWSFVRDDQ-PRSETCKQLALVLRDEVLNLEKAGIKIIQIDEPAVREGLplrKSDWNTYLKWAVDCFKltTSGVeiDTQIHTHM 673
                  457889***************99.9999******999988889****************988755444555555666665542233330145566667 PP

                  -SS-.CCHHHHHTTSSTSEEEEETSS.HCHHHHHHHHCTT.TT CS
  Meth_synt_1 239 yFdsvaealellaelpveglglDlvr.aeenlealkkaglped 280
                   + ++++ ++ + +++ + ++++  r + e l+a++++++p+d
   EFC37875.1 674 CYSEFNDIIDSIGAMDADVISIETSRsNMELLQAFEDFKYPND 716
                  89**********************9978888899998887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (789 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       631  (0.0351944); expected 358.6 (0.02)
Passed bias filter:                      533  (0.0297284); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.35s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 4696.64
//
Query:       EFC37876.1  [L=810]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   15.1   0.1      0.047   13.8   0.1    1.7  1  TPR_2     Tetratricopeptide repeat
       0.37   11.5   1.8       0.96   10.2   0.0    2.7  3  TPR_6     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   5.2e-06     0.047       5      34 .]     767     796 ..     766     796 .. 0.95

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 5.2e-06
       TPR_2   5 ynlGlayyklgdyeeAleafekAleldPnn 34 
                 yn +  +++++++e+A+++fe+ l+ +P++
  EFC37876.1 767 YNAAIDCFEKNEFEQAKQFFEEFLSKNPQD 796
                 889999**********************86 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1         2   1.8e+04      23      33 .]     330     340 ..     328     340 .. 0.88
   2 ?   -1.2   0.0      0.46   4.1e+03       2      26 ..     542     566 ..     541     570 .. 0.73
   3 ?   10.2   0.0   0.00011      0.96       4      32 ..     767     795 ..     766     796 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2
                 HHHHHHH-TT- CS
       TPR_6  23 lerlikeYPdS 33 
                 ++++ ++Y +S
  EFC37876.1 330 YNQFKTNYKNS 340
                 999*****987 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.46
                 HHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerl 26 
                 Aly  +ls++ ++   + +e+l  l
  EFC37876.1 542 ALYIKGLSQLFAQHLKTEKEILHVL 566
                 99*******9854776666666665 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00011
                 HHHH.HHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   4 ykla.lsyrklgdtdkAlealerlikeYPd 32 
                 y++a  +++k  + ++A++ +e+++++ P+
  EFC37876.1 767 YNAAiDCFEKN-EFEQAKQFFEEFLSKNPQ 795
                 66664577777.****************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (810 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1799  (0.10034); expected 358.6 (0.02)
Passed bias filter:                      583  (0.0325172); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.80u 0.33s 00:00:01.13 Elapsed: 00:00:00.49
# Mc/sec: 4935.64
//
Query:       EFC37877.1  [L=487]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-07   30.2   0.1    5.7e-07   29.6   0.1    1.2  1  DUF4832   Domain of unknown function (DUF4832)
    3.9e-06   26.6   0.0    7.9e-06   25.6   0.0    1.4  1  DUF4874   Domain of unknown function (DUF4874)


Domain annotation for each model (and alignments):
>> DUF4832  Domain of unknown function (DUF4832)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6   0.1   6.4e-11   5.7e-07       2     201 ..     186     393 ..     185     403 .. 0.75

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 6.4e-11
     DUF4832   2 lGlhnDgflasesdlgTy........eseerteelayleeetk...yvpvGGEvvltcklndkeses.lekalkelakmhvsyLnsdydeavldkwksq 88 
                 +G+h+D+f  s  +  +          ++   +  ++l++ +      ++GGE+  + +++  ++++ ++   + ++k+  ++L +dy  + l++  ++
  EFC37877.1 186 IGFHDDAFADSTYSATSGkdyyfynrLQSRIPDINSFLTASNGgkgGGVMGGELYPSYQSKIFKTTWtGQDFSQCVKKTNATWLLNDYVFSTLANSPTT 284
                 7899997777666655557788888534444444455555555666889****88888887766655999*****************977777777776 PP

     DUF4832  89 gvegrsvydyirkhLGYRfvlessslskkvkaggtlsleltlkNeGfAa.lynerkvelvlrdeegeekyklkldadprkwlpgtttt.itiklklpse 185
                 ++    +  + +  LGY f+l+++++++    + +l+l++ ++N G A+ +y + ++ ++l++ ++++ +  ++ +++ +++p +  + i+++lk    
  EFC37877.1 285 EW---YAARNASLMLGYAFTLRNVEMTSIT--STSLTLTFGMENIGSAPfPYLDINLAVYLKNATTKALIASNEATSIYQLTPASGSQnIKVNLKWSTP 378
                 66...678899999************8766..5***************9569999***********998778889999999996543324444333333 PP

     DUF4832 186 lakGkykvyLnlpdps 201
                 +++    vy+nl++++
  EFC37877.1 379 ITTS-PYVYVNLKSKQ 393
                 4444.45777777665 PP

>> DUF4874  Domain of unknown function (DUF4874)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.0   8.8e-10   7.9e-06      52     129 ..      11     121 ..       6     145 .. 0.82

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 8.8e-10
     DUF4874  52 dklekiletlrkagkkvilRfaYdte..............................gkateeedasleqilrHieqlkpile.enk..dvIavvqagfi 117
                 ++le +l+ +++++ ++i+R+  d+                               + + ++ d s e++ + ieql + l  ++   + Ia+vq g++
  EFC37877.1  11 ATLEPYLNNVKSRKRQAIFRIYLDYPnccpdgqyntgvpdflltganpvtftsypdYGGGKSPDYSNERLVSSIEQLIAELArKYDgdNRIAYVQVGIL 109
                 56777888889999999999888888889999999999999999999999999988788899999***********86655515546579********* PP

     DUF4874 118 GawGEwhssknl 129
                 G+wGE h++ n+
  EFC37877.1 110 GYWGEFHTYPNT 121
                 ********9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (487 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       583  (0.0325172); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.27s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 2978.68
//
Query:       EFC37878.1  [L=459]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0026   17.1   0.0     0.0066   15.8   0.0    1.7  1  Amino_oxidase  Flavin containing amine oxidoreductase
  ------ inclusion threshold ------
       0.13   12.4   0.1          2    8.5   0.0    2.5  2  Trans_coact    Phage late-transcription coactivator


Domain annotation for each model (and alignments):
>> Amino_oxidase  Flavin containing amine oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   7.3e-07    0.0066     194     452 .]     137     433 ..     101     433 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 7.3e-07
                    HHHHHTSCCCEETTHTHHHHHHHHH..TTTTEEEETSEEEEEEEEETTC.....EEEEETTSTEE..EESEEEE-S-HHHHHSSEEES.CC.SHHH CS
  Amino_oxidase 194 elegfggslllprgGlsqlpealae..elrgldirlntrVkeikregdg.....vtvtledgevv..eaDaVvvTvplgvlkailfsP.pl.pdek 278
                    + +++gg+  +p++G + ++e+l +  +++g+d+   + V +i+ +++g     + ++  + +++  e   V++ + +++    ++ P p   +  
     EFC37878.1 137 NIFKNGGH--IPKEGADDIVESLIKviRKGGGDVMSKANVASIHINKEGkcggvCVLK--NKDSIiiESPIVISSAGVYNTY-SKLIPrPIrEKLG 227
                    33444444..88*********************************4444444334444..4444455999999999999999.8888889977799 PP

                    HHHHHHSEEEEEEEEEEEESSGGSGCSTSE.CE..CECCCEEETTTEEEEECC..............ECCCSTTTEEE..EEEEEECHHHHHHH.. CS
  Amino_oxidase 279 aeairnlgfgsvnkvilefdrkfwednalg.qg..vlvseltttlgeafissd..............fpsrappgkgl..vllvyvggdaanel.. 353
                     + ++  ++ sv   +l +d+   e+++l+ q      + + ++  ++++ sd                + +p  +++   +l++ +  +++e+  
     EFC37878.1 228 YNHFKYTPSYSVQATFLGYDGTI-EELGLKfQNyfIMTNPDFDGQFTRYMESDgdidpkngidipilIANLRPYNNKVsmTILSFANHAWFQEWnh 322
                    9999999***************9.88776544456444444444444444444222222223333553333333332256899999999*****65 PP

                    .....TTS-HHHHHHHHHHHHHHH.HTGTSSTCSEEEEEECCTETTTSSSEEE.BTTHHHHHHHHHHCH..........HCSTTEEE.SGGGCTTT CS
  Amino_oxidase 354 .....eslsdeelvqavlrdLrkl.fgeevpepkatlvtrWhtdplargsysyvsvgpghedydplakp..........egdprlffAGehtsrey 433
                          s++ e+l++++ +   +l +  ++p+ ++ + +  +++p++   y  +++g  +   + +  +           ++ +lf+ G  +    
     EFC37878.1 323 qrvgqRSVDYEDLKERIANRALELlYM-KHPQLENRHSVMSTSSPITFNHYLSNNFGDYMGFKRVVGNDdgvfrwgrpmSNLENLFLVGQDIF--- 414
                    554443335555555555443333133.3333333333333459999999*99****96666666666666666666667799********88... PP

                    TTSHHHHHHHHHHHHHHHH CS
  Amino_oxidase 434 pgtvegAilSGlraAaril 452
                     g+v+gA+lS+l ++ ++l
     EFC37878.1 415 AGGVQGAMLSALITCGCVL 433
                    888**********999886 PP

>> Trans_coact  Phage late-transcription coactivator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0   0.00023         2      35      52 ..     212     229 ..     210     232 .. 0.88
   2 ?    0.6   0.0     0.067     6e+02      43      62 ..     333     352 ..     332     359 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00023
  Trans_coact  35 eqvpklIskpLkeKikaE 52 
                  ++++klI++p++eK+ ++
   EFC37878.1 212 NTYSKLIPRPIREKLGYN 229
                  789***********9775 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.067
  Trans_coact  43 kpLkeKikaEAielnllkps 62 
                  + Lke+i + A el ++k  
   EFC37878.1 333 EDLKERIANRALELLYMKHP 352
                  579**************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       497  (0.0277205); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 2872.87
//
Query:       EFC37879.1  [L=295]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.4e-09   36.9   2.4    0.00076   19.3   0.3    2.5  2  F-box-like  F-box-like
    4.2e-06   26.5   1.5      0.014   15.3   0.1    3.2  3  F-box       F-box domain
  ------ inclusion threshold ------
       0.11   12.9   0.5       0.33   11.3   0.5    1.8  1  GCR1_C      Transcriptional activator of glycolytic enzymes


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.1   6.2e-07    0.0037       2      15 ..       2      15 ..       1      28 [. 0.75
   2 !   19.3   0.3   1.3e-07   0.00076      21      43 ..     199     220 ..     188     221 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 6.2e-07
  F-box-like  2 srLPdEiLlqIFsy 15
                 +LP+EiL++IFs+
  EFC37879.1  2 ENLPNEILIHIFSF 15
                69**********96 PP

  == domain 2  score: 19.3 bits;  conditional E-value: 1.3e-07
  F-box-like  21 LlrlalVCrrWrrvaldtplLWr 43 
                 +++l+lV+r+W+++a +  +LW 
  EFC37879.1 199 YCNLSLVSRQWKEAADNQ-SLWE 220
                 69*************666.***5 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.2   0.00034         2       5      17 ..       3      15 ..       1      15 [. 0.89
   2 !   15.3   0.1   2.3e-06     0.014      23      44 ..     199     220 ..     193     223 .. 0.93
   3 ?   -0.3   0.0      0.18   1.1e+03      29      48 .]     221     240 ..     220     240 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00034
                HS-HHHHHHHHHT CS
       F-box  5 rLPsevlrhILer 17
                +LP+e+l hI+++
  EFC37879.1  3 NLPNEILIHIFSF 15
                8**********85 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 2.3e-06
                 HHHHCTT-HHHHHHHTTHHHHH CS
       F-box  23 llalrrVSkgwrilidsdrlwc 44 
                 +++l++VS+ w+ + d+ +lw 
  EFC37879.1 199 YCNLSLVSRQWKEAADNQSLWE 220
                 69******************96 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.18
                 T-HHHHHHHTTHHHHHHHHH CS
       F-box  29 VSkgwrilidsdrlwcksir 48 
                 VS+g+ + + ++r ++++ir
  EFC37879.1 221 VSTGMLQQLLRLRSDLEFIR 240
                 999*9999999999999986 PP

>> GCR1_C  Transcriptional activator of glycolytic enzymes
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.5   5.5e-05      0.33       9      57 ..     108     153 ..     103     163 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5.5e-05
      GCR1_C   9 tVedlwnEykeglngkpsikslekkygkrWrkdskesklfsrRkkiidf 57 
                  V ++ +E++e  n + +i+ l  + +++W ++s+    ++ R  ++ +
  EFC37879.1 108 DVGSIREEWFENENRQNNIEILFSSSESKWSNNSE---SYNDRLNLLHE 153
                 68999**************************6666...78888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       786  (0.0438396); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.40u 0.25s 00:00:00.65 Elapsed: 00:00:00.41
# Mc/sec: 2171.20
//
Query:       EFC37880.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1205  (0.0672095); expected 358.6 (0.02)
Passed bias filter:                      602  (0.0335769); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 999.35
//
Query:       EFC37881.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.5e-51  173.6   0.3    6.2e-51  173.5   0.3    1.0  1  Cellulase  Cellulase (glycosyl hydrolase family 5)


Domain annotation for each model (and alignments):
>> Cellulase  Cellulase (glycosyl hydrolase family 5)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  173.5   0.3   3.5e-55   6.2e-51      22     281 .]      13     265 ..       1     265 [. 0.86

  Alignments for each domain:
  == domain 1  score: 173.5 bits;  conditional E-value: 3.5e-55
                 SHHHHHHHHHHHT-SEEEEEEECTGGTTSSTTTGCTHHHHHHHHHHHHHHHHTT-EEEEEEESSTTTCSSSSTTTTHHHHHHHHHHHHHHHHHHHTTTT CS
   Cellulase  22 ttkalidevkdagfntvRlpvswgelvenapdykvdenslerveevvkyakenglyvildiHseegwltkadgnssedtaeeffkklwtqiAerykknd 120
                 ++ ++   v++++ n++Rlp+ w++l++ + +   d+  l+r+++vv  +  +g+ v+ld+H++ g+   +   +++d+ +e f+++w  +A++y   +
  EFC37881.1  13 SASDISLYVATMNLNVIRLPFKWDRLQP-KHGQPLDSLELARIDAVVSVCATHGVSVLLDPHNY-GY-SVNGLIGTSDEPTENFTDFWIRLAQHY-LGY 107
                 5677788899*****************6.555569****************************8.44.566689999999999************.788 PP

                 TTEEEESSSS--STTCTCCTCHHHTTHHHHHHHHHHHHHHHHTTSSEEEEECHH......HHT.....BHHHHHCTSGSSSSTTEEEEEEEETTTHHHT CS
   Cellulase 121 evvifelmNEPhgnntgaewtseeadevkayaeeaikaIRavgpnrliivegns......wsg.....nldgavlndPndsqdnliysvHfYgpsdfaq 208
                 ++vif +mNEPh   t+         ++++ a+++++aIR++g+++l++v+g+       w++     ++ +a +n  +ds++n ++++H+Y +sd ++
  EFC37881.1 108 DNVIFGIMNEPHT-HTPL--------QWADIAQTTLNAIRSTGATQLVLVPGTFytgahsWTSnvlgqSNAEALKNI-KDSANNFMFEMHQYLDSDNSG 196
                 89***********.4554........56************************8866666644444442333333334.678****************** PP

                 GCGSHSCTHHHHHHHHHHHHHHHHHHTTSEEEEEEEESSTTSSHHHHHHHHHHHHHHHHTTTEEEEEEESSSS CS
   Cellulase 209 tefgkdltdktnlaqrledaakylvekgipviigEfGgsnadgdlakeeaekwldylkekgiswiyWslnpks 281
                 t++  +++++t+   rl++++++l+++g ++++gEfG+s+ +   + ++   +l+++ ++  +w +W+++++s
  EFC37881.1 197 THS--TCVSSTIGSTRLKTTTDWLRQNGFKAFLGEFGASDDTV--CMQALYDILQFMGNNTDVWHGWTYWNAS 265
                 ***..********************************976666..99999999*****************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       440  (0.0245412); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1809.08
//
Query:       EFC37882.1  [L=628]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.007   15.2   0.8      0.013   14.3   0.8    1.3  1  Tektin    Tektin family
  ------ inclusion threshold ------
      0.025   14.8   0.5       0.08   13.2   0.4    1.9  1  Imm5      Immunity protein Imm5
       0.54   10.6   5.1         18    5.7   0.6    3.0  3  TSC22     TSC-22/dip/bun family


Domain annotation for each model (and alignments):
>> Tektin  Tektin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.8   2.2e-06     0.013      20     101 ..     444     525 ..     434     527 .. 0.95

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.2e-06
      Tektin  20 erlrnesrrlideteektkktqadsnkrLeeRiediefwkeeLekeleelkeeieaLeeekrrlekalealeeplhiaqecl 101
                 + + n++  l++e++++  ++ ++s k L+e  e+ +  ++ + kel   ++e+ +Le  k ++e al ++++ ++i +e +
  EFC37882.1 444 DSISNQCIYLREEASKTFIQQIKESMKTLGELFEERNSSRRNITKELMIFQTETYLLEGLKANIEFALHNVKHAIEIYEEVI 525
                 5688999**********************************************************************99875 PP

>> Imm5  Immunity protein Imm5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.4   1.3e-05      0.08      21      99 ..     483     572 ..     470     625 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.3e-05
        Imm5  21 Rvkllraigsprviqk..........laiecvkkvlplweevfaedqsplrlLekaedylyektdkeeiekeadklsndlen.dsgeeae 99 
                 R+++ +++  +++              a+  vk+++++ eev+++d++++r+++k e++l  +++ + ++++ + l++  ++ +++ e +
  EFC37882.1 483 RRNITKELMIFQTETYlleglkanieFALHNVKHAIEIYEEVIGKDEIIARVISKYEATLNSSVSGQFLNQNLKLLEESFDDmKYHFEMK 572
                 5566665555554444666677776678889*******************************9999999999888877777666655544 PP

>> TSC22  TSC-22/dip/bun family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.6     0.003        18      15      41 ..     148     174 ..     142     188 .. 0.88
   2 ?    5.6   0.1    0.0033        20      25      55 ..     438     468 ..     430     470 .. 0.87
   3 ?    2.3   0.1     0.037   2.2e+02      21      49 ..     463     491 ..     450     496 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.003
       TSC22  15 eVevLkekIkeLeernseleeENslLk 41 
                  +++L +k  +L+e+ +++e +N  Lk
  EFC37882.1 148 NIDNLSNKLIDLLEQFHTVELDNINLK 174
                 589********************9999 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0033
       TSC22  25 eLeernseleeENslLkalaspeqleqlsak 55 
                  L+ r+  + +++ +L++ as+  ++q++++
  EFC37882.1 438 RLLRRIDSISNQCIYLREEASKTFIQQIKES 468
                 49999**********************9986 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.037
       TSC22  21 ekIkeLeernseleeENslLkalaspeql 49 
                 ++Ike +++  el eE +  ++++++e +
  EFC37882.1 463 QQIKESMKTLGELFEERNSSRRNITKELM 491
                 68999999999999999999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (628 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       901  (0.0502538); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.29s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 3742.16
//
Query:       EFC37883.1  [L=599]
Description: TPR domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.5e-09   36.1   1.3      0.035   14.2   0.0    4.3  4  TPR_2        Tetratricopeptide repeat
    1.3e-07   31.2   6.3      0.038   13.8   0.0    4.9  5  TPR_1        Tetratricopeptide repeat
      1e-05   25.7   0.3    0.00074   19.8   0.0    2.4  2  TPR_12       Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.017   15.0   0.0      0.039   13.8   0.0    1.5  1  F-box-like   F-box-like
      0.021   14.3   0.1        6.2    6.4   0.0    2.6  2  SHNi-TPR     SHNi-TPR
       0.11   12.8   0.0       0.32   11.4   0.0    1.8  1  OB_NTP_bind  Oligonucleotide/oligosaccharide-binding (OB)-fol
       0.12   12.3   0.0       0.26   11.2   0.0    1.5  1  F-box        F-box domain
        1.1    9.6   3.3         16    6.0   0.0    3.5  5  TPR_8        Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.57   1.3e+03       5      27 ..      91     113 ..      90     114 .. 0.76
   2 !    5.7   0.1    0.0081        18       3      29 ..     128     154 ..     126     157 .. 0.92
   3 !   10.8   0.1   0.00019      0.43       3      30 ..     241     268 ..     240     272 .. 0.92
   4 !   14.2   0.0   1.6e-05     0.035       4      29 ..     281     306 ..     279     309 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.57
       TPR_2   5 ynlGlayyklgdyeeAleafekA 27 
                 +++  a ++  ++eeA+e+ e A
  EFC37883.1  91 MRRSIARMEISKFEEAVEDVEMA 113
                 5677788888899***9987766 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0081
       TPR_2   3 alynlGlayyklgdyeeAleafekAle 29 
                 +ly lG+a y +  y +A++ f kA+ 
  EFC37883.1 128 VLYILGMAQYGACLYRDAAHTFMKAID 154
                 79**********************985 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 0.00019
       TPR_2   3 alynlGlayyklgdyeeAleafekAlel 30 
                 ++ + Glay+ ++ y+ A+ +f  A+ l
  EFC37883.1 241 LYIRAGLAYFDANIYQNAIPLFTHAIDL 268
                 68999********************988 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 1.6e-05
       TPR_2   4 lynlGlayyklgdyeeAleafekAle 29 
                  yn+Gl+yy + d+++Ale+f  +++
  EFC37883.1 281 FYNRGLCYYFSWDFQQALEDFSHSIQ 306
                 69*******************98876 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.067   1.5e+02      14      28 ..     100     114 ..      95     116 .. 0.83
   2 ?    4.2   0.1     0.019        42       3      29 ..     128     154 ..     126     158 .. 0.91
   3 !    9.7   0.2   0.00034      0.77       4      30 ..     242     268 ..     240     272 .. 0.90
   4 !   13.8   0.0   1.7e-05     0.038       3      30 ..     280     307 ..     279     308 .. 0.91
   5 ?   -1.8   0.1       1.5   3.4e+03      21      32 ..     333     344 ..     333     345 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.067
                 TT-HHHHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyekAL 28 
                   k++eA+e+ e A+
  EFC37883.1 100 ISKFEEAVEDVEMAI 114
                 579*******99998 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.019
                 HHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALe 29 
                 +ly lG+a +    y +A   + kA+ 
  EFC37883.1 128 VLYILGMAQYGACLYRDAAHTFMKAID 154
                 6899*********************97 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00034
                 HHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   4 lynlGnayfklgkydeAleyyekALel 30 
                 + + G+ayf  + y+ A+  +  A+ l
  EFC37883.1 242 YIRAGLAYFDANIYQNAIPLFTHAIDL 268
                 6777********************987 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 1.7e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALel 30 
                 ++yn+G++y+   ++++Ale+++  +++
  EFC37883.1 280 SFYNRGLCYYFSWDFQQALEDFSHSIQV 307
                 58********************988875 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 1.5
                 HHHHHHHHHHST CS
       TPR_1  21 leyyekALelnP 32 
                 +e+y+ A  +nP
  EFC37883.1 333 EEDYNCARNINP 344
                 59*****99999 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.1     0.033        74      10      76 ..      94     157 ..      85     158 .. 0.76
   2 !   19.8   0.0   3.3e-07   0.00074       6      75 ..     242     308 ..     237     310 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.033
      TPR_12  10 aavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaiae 76 
                   + ++  +++eA e  e a+ ++  +  +++ +  ++l+ Lg++++ +  y++A   + +a++ +e
  EFC37883.1  94 SIARMEISKFEEAVEDVEMAIWLMD-T--EERRNHFIVLYILGMAQYGACLYRDAAHTFMKAIDNRE 157
                 5555666677888888888866663.3..4556789999************************9988 PP

  == domain 2  score: 19.8 bits;  conditional E-value: 3.3e-07
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaia 75 
                 + + +++++ +  y+ A+ l+ +a+++ +++   +++++ ++ +n g +y+ + ++++Ale + +++++ 
  EFC37883.1 242 YIRAGLAYFDANIYQNAIPLFTHAIDLGSKY---KSDNVGSSFYNRGLCYYFSWDFQQALEDFSHSIQVQ 308
                 4467888888888***************988...3456***********99888*******999998875 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.7e-05     0.039      11      41 ..     364     392 ..     360     398 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.7e-05
  F-box-like  11 qIFsyLppsdLlrlalVCrrWrrvaldtplL 41 
                 + +s+L++++++++ ++C++W++++  t +L
  EFC37883.1 364 HMLSFLETKQIVQVVRTCKHWKSLV--TKYL 392
                 5689********************9..6565 PP

>> SHNi-TPR  SHNi-TPR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0028       6.2      12      27 ..      98     113 ..      97     116 .. 0.85
   2 ?    5.1   0.1    0.0069        15      17      33 ..     294     310 ..     293     313 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0028
    SHNi-TPR  12 lEnenFpqAveDlrka 27 
                 +E ++F++AveD + a
  EFC37883.1  98 MEISKFEEAVEDVEMA 113
                 799*********7655 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0069
    SHNi-TPR  17 FpqAveDlrkaLeLreq 33 
                 F qA+eD+  +++ +++
  EFC37883.1 294 FQQALEDFSHSIQVQTK 310
                 99*********998876 PP

>> OB_NTP_bind  Oligonucleotide/oligosaccharide-binding (OB)-fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00014      0.32       4      62 ..     317     373 ..     316     390 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00014
                  HHHHHHTTCEEEEEETTCCEEETT.TCEEEEE-TTSTTTTT...TSSSEEEEEEEEESSS CS
  OB_NTP_bind   4 illaGlypqiarkdpskkdyktar.tktrvfihpsSvlaknekekepewvvytelvettk 62 
                  i+ ++l+++i+++d+ ++dy++ar ++ rv+    S +++    +e++++   +++et+ 
   EFC37883.1 317 IMRSSLFSRIGKQDEYEEDYNCARnINPRVYKSGLSQYRH---MSEDTFFHMLSFLETKQ 373
                  57789*******************8999999999999887...46666777777777765 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00012      0.26      15      38 ..     366     389 ..     357     391 .. 0.93

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00012
                 HHTS-HHHHHHHCTT-HHHHHHHT CS
       F-box  15 LerLplsdllalrrVSkgwrilid 38 
                 L++L+++ ++   r++k+w++l+ 
  EFC37883.1 366 LSFLETKQIVQVVRTCKHWKSLVT 389
                 89*******************986 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0         8   1.8e+04      16      23 ..     102     109 ..      97     111 .. 0.76
   2 ?   -2.8   0.0       4.6     1e+04      18      29 ..     143     154 ..     129     157 .. 0.69
   3 ?    6.0   0.0    0.0073        16       4      30 ..     242     268 ..     240     270 .. 0.94
   4 ?    2.2   0.0      0.12   2.6e+02       3      29 ..     280     306 ..     278     310 .. 0.87
   5 ?   -3.7   0.0         8   1.8e+04       7      24 ..     319     336 ..     317     337 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 8
                 -HHHHHHH CS
       TPR_8  16 dyeeAkey 23 
                 ++eeA+e 
  EFC37883.1 102 KFEEAVED 109
                 68899875 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 4.6
                 HHHHHHHHHHHH CS
       TPR_8  18 eeAkeyyekale 29 
                   A  +++ka++
  EFC37883.1 143 RDAAHTFMKAID 154
                 456667788875 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0073
                 HHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekalel 30 
                 y + g++y++ + y++A+  + +a++l
  EFC37883.1 242 YIRAGLAYFDANIYQNAIPLFTHAIDL 268
                 8999********************986 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.12
                 HHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekale 29 
                 + yn g++y    d+++A e + + ++
  EFC37883.1 280 SFYNRGLCYYFSWDFQQALEDFSHSIQ 306
                 789****************99988876 PP

  == domain 5  score: -3.7 bits;  conditional E-value: 8
                 HHHHHHHTT-HHHHHHHH CS
       TPR_8   7 lgsiylklgdyeeAkeyy 24 
                  +s+ +  g+ +e +e y
  EFC37883.1 319 RSSLFSRIGKQDEYEEDY 336
                 678888899999877777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (599 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       913  (0.0509231); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.72u 0.29s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 3560.94
//
Query:       EFC37884.1  [L=1155]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-19   68.7   1.1    9.3e-15   54.6   0.1    3.2  3  Pkinase_Tyr     Protein tyrosine kinase
    1.6e-18   67.1   0.1      4e-18   65.7   0.1    1.6  1  Pkinase         Protein kinase domain
  ------ inclusion threshold ------
      0.027   13.3   0.0      0.047   12.5   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase
      0.045   14.0   0.1      0.091   13.0   0.1    1.4  1  Shisa           Wnt and FGF inhibitory regulator
      0.098   12.9   0.9       0.23   11.7   0.9    1.5  1  VirB3           Type IV secretory pathway, VirB3-like protein


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1     0.073   2.6e+02       1      21 [.     924     944 ..     924     952 .. 0.90
   2 !   54.6   0.1   2.6e-18   9.3e-15     127     233 ..     957    1063 ..     948    1071 .. 0.87
   3 !   10.1   0.0   9.5e-05      0.34     236     259 .]    1122    1145 ..    1113    1145 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.073
                  EEEEEEEEEESSEEEEEEEEE CS
  Pkinase_Tyr   1 lelgkklGeGafGkVvegtlk 21 
                  +e+++k++eGa G+V++g++ 
   EFC37884.1 924 IEIQQKVAEGAQGSVFKGKWF 944
                  57899**************97 PP

  == domain 2  score: 54.6 bits;  conditional E-value: 2.6e-18
                   ST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTS..HHHHHHHHHHT CS
  Pkinase_Tyr  127 rdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypgl..kneevleklke 220 
                   rdl   NvLl++++++ki+D G+++ +   d++v+k+++   +++ma+E+++ +++++k Dv+s++++lw ++   +  y++   kn++v  ++++
   EFC37884.1  957 RDLKPGNVLLDNQMKAKICDLGVSKIV--ADNMVEKTNQIGTFNFMAIETFNGTEYNEKCDVFSYAIILWQLIFEENAIYSNEllKNKRVSYFMTD 1050
                   9************************99..9999**************************************9887777776543688888888887 PP

                   TEES-BBTTSBHH CS
  Pkinase_Tyr  221 gkrlekpekcpee 233 
                   + r    + +p++
   EFC37884.1 1051 QDRQVYEKLTPQN 1063
                   7776666666555 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 9.5e-05
                   HHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  236 elmkkcweedpeeRptfselvekl 259 
                   +l+++cw++d ++Rp+fs +v+kl
   EFC37884.1 1122 SLIESCWRADYNQRPSFSFIVKKL 1145
                   7899****************9987 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.7   0.1   1.1e-21     4e-18     121     260 ..     956    1143 ..     949    1145 .. 0.80

  Alignments for each domain:
  == domain 1  score: 65.7 bits;  conditional E-value: 1.1e-21
                  -SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSS...HHHHHHHHHHTH CS
     Pkinase  121 HrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgek...gkekvekeldql 213 
                  +rDlKp N+L+d++ + Ki+D+G++k +  +   +t+++gt +++A E  +++ey +k+Dv+s+++il++l+++++  ++++   +k   + ++dq 
  EFC37884.1  956 FRDLKPGNVLLDNQMKAKICDLGVSKIVADNMVeKTNQIGTFNFMAIETFNGTEYNEKCDVFSYAIILWQLIFEENAIYSNEllkNKRVSYFMTDQD 1052
                  7*************************998776559************************************99988777332111222223333333 PP

                  HHHHHHCTSHH...HHHTTS.................................................-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase  214 ekilkilgetkeklpeasei.................................................seeakdllkkllkkdpkkRltaeellq 260 
                   ++++ l++++++                                                         +   +l++++++ d ++R++++ +++
  EFC37884.1 1053 RQVYEKLTPQNFNN-----YyiakliseglryplpsisksleeekklfvwveeymnqegidtsrltiriLPIYFSLIESCWRADYNQRPSFSFIVK 1143
                  33333333322222.....24466689999999999999999999999999999999999999999999888999999999999999999887765 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   1.3e-05     0.047     331     396 ..     957    1015 ..     946    1026 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.3e-05
  Pkinase_fungal  331 rDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhD 396 
                      rD   +N+l+      ++ k  + DL + k ++d ++ + + +++GT +Fmaie  +g+e +   D
      EFC37884.1  957 RDLKPGNVLLD-----NQMKAKICDLGVSKIVAD-NMVE-KTNQIGTFNFMAIETFNGTEYNEKCD 1015
                      899999**999.....678899***********7.4444.479************99877555555 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   2.5e-05     0.091      84     142 ..     843     903 ..     813     915 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.5e-05
       Shisa  84 vpvlivktifivfvivgvvvi.vcccgclkkkqrekrpgrenlssalaevgpivte..ttsa 142
                 v v  ++ +f+  ++++v+vi ++  + l+k qr+k+ ++++l+  l + +   t+  +t+a
  EFC37884.1 843 VGVT-ISALFVGCIVCIVLVIfTVKFCFLYKDQRRKAKKEKELEMKLRDFELNYTKlgDTNA 903
                 3332.377899999999977615569999*******96666665555555322222223333 PP

>> VirB3  Type IV secretory pathway, VirB3-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.9   6.3e-05      0.23       9      43 ..     836     870 ..     833     871 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 6.3e-05
       VirB3   9 ltRpamllGvplelvllnllvsvilflvglslwil 43 
                  +Rp+ + Gv+++++ + ++v+++l+++++ + +l
  EFC37884.1 836 SNRPSIIVGVTISALFVGCIVCIVLVIFTVKFCFL 870
                 58*************************99998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1155 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       684  (0.0381505); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.90u 0.30s 00:00:01.20 Elapsed: 00:00:00.51
# Mc/sec: 6805.04
//
Query:       EFC37885.1  [L=131]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.8e-15   54.3   5.5     0.0013   18.7   0.1    5.2  5  LRR_6     Leucine Rich repeat
    2.8e-07   30.2   3.3    0.00024   20.8   0.8    2.3  2  LRR_8     Leucine rich repeat
    1.1e-05   25.7  15.4    0.00014   22.1   2.2    3.8  3  LRR_4     Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
      0.097   13.3   7.8        3.8    8.4   0.1    4.3  4  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   7.3e-07    0.0033       4      24 .]       3      23 ..       1      23 [. 0.87
   2 !   13.4   0.1   1.4e-05     0.061       5      20 ..      28      43 ..      25      47 .. 0.91
   3 ?   -0.2   0.0       0.3   1.4e+03       4      17 ..      51      64 ..      51      67 .. 0.86
   4 ?    2.7   0.0     0.037   1.7e+02       5      23 ..      75      93 ..      72      94 .. 0.88
   5 !   18.7   0.1   2.8e-07    0.0013       5      24 .]      99     118 ..      96     118 .. 0.91

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 7.3e-07
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                 Lt L++s N+Ig+eG + ++
  EFC37885.1  3 QLTCLSVSNNNIGNEGFKFIC 23
                69**************77665 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 1.4e-05
       LRR_6  5 LteLdLsgNdIgDeGa 20
                Lt+Ld+  NdI+ +G+
  EFC37885.1 28 LTYLDVGRNDINSKGL 43
                9*************98 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.3
       LRR_6  4 hLteLdLsgNdIgD 17
                +L+ L + +N +gD
  EFC37885.1 51 KLKDLRIYYNSVGD 64
                58999999999998 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.037
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt L+++  +I+ +Ga+ +
  EFC37885.1 75 LTNLNVNTACINEKGAKFI 93
                999****99**99999977 PP

  == domain 5  score: 18.7 bits;  conditional E-value: 2.8e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 +t L++s+N+Ig++G+e ++
  EFC37885.1  99 VTNLNISFNEIGNQGLEHIS 118
                 689**************986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.8   5.4e-08   0.00024       1      59 [.       2      60 ..       2      62 .. 0.95
   2 !    9.7   0.1   0.00016      0.72      22      61 .]      70     109 ..      64     109 .. 0.91

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 5.4e-08
                TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59
                ++Lt L++snN++ + + ++   +++L++Ld ++N +++   + + +L +L+ L + +N
  EFC37885.1  2 RQLTCLSVSNNNIGNEGFKFICEMKQLTYLDVGRNDINSKGLNHITNLDKLKDLRIYYN 60
                68999*************************************************99888 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00016
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + +++L+ L+ +  +++   ++ +s Lp ++ L++s N +
  EFC37885.1  70 SEMKQLTNLNVNTACINEKGAKFISELPLVTNLNISFNEI 109
                 67999********************************986 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   2.2   3.2e-08   0.00014       2      43 ..       3      53 ..       2      54 .. 0.82
   2 !    7.4   0.9    0.0014       6.1       2      31 ..      51      81 ..      41      96 .. 0.79
   3 ?    4.0   2.2     0.017        74       4      30 ..     100     126 ..      89     131 .] 0.68

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 3.2e-08
                S--EEE--SS---E-S-.HH.H-TT--EEE-.-S.......-----GGGGX CS
       LRR_4  2 nLevLdLsnNqltdipl.le.klpnLkeLdLsgN.......nlitdldeLk 43
                +L+ L+ snN++   ++ +   +++L++Ld+ +N       n it+ld+Lk
  EFC37885.1  3 QLTCLSVSNNNIGNEGFkFIcEMKQLTYLDVGRNdinskglNHITNLDKLK 53
                69***********877784434*********88977788888888888775 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0014
                S--EEE--SS---E-S-...HHH-TT--EEE-. CS
       LRR_4  2 nLevLdLsnNqltdipl...leklpnLkeLdLs 31
                +L+ L +  N + d  +   ++ +++L+ L+++
  EFC37885.1 51 KLKDLRIYYNSVGD--GakyISEMKQLTNLNVN 81
                68889999899997..43344459999999993 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.017
                 -EEE--SS---E-S-HHH-TT--E.EE- CS
       LRR_4   4 evLdLsnNqltdiplleklpnLke.LdL 30 
                 ++L++s N +   ++le +  +k+ L++
  EFC37885.1 100 TNLNISFNEIG-NQGLEHISRMKTvLNC 126
                 67788877888.5566667777775665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1     0.029   1.3e+02       2      15 ..       4      17 ..       3      25 .. 0.74
   2 ?    8.4   0.1   0.00084       3.8       1      23 []      27      49 ..      27      49 .. 0.91
   3 ?    0.6   0.0      0.32   1.4e+03       1      12 [.      51      62 ..      51      86 .. 0.76
   4 ?    2.1   0.2       0.1   4.5e+02       5      17 ..     102     114 ..      99     120 .. 0.70

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.029
       LRR_1  2 LrhLdLsnnpllgl 15
                L+ L +snn++++ 
  EFC37885.1  4 LTCLSVSNNNIGNE 17
                889******98543 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00084
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                +L++Ld+++n + +++ n++ nL
  EFC37885.1 27 QLTYLDVGRNDINSKGLNHITNL 49
                59**********99999999876 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.32
       LRR_1  1 nLrhLdLsnnpl 12
                +L+ L + +n+ 
  EFC37885.1 51 KLKDLRIYYNSV 62
                688899988885 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.1
       LRR_1   5 LdLsnnpllglpp 17 
                 L++s n +++ + 
  EFC37885.1 102 LNISFNEIGNQGL 114
                 99**999855444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       500  (0.0278878); expected 358.6 (0.02)
Passed bias filter:                      293  (0.0163422); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.43
# Mc/sec: 906.30
//
Query:       EFC37886.1  [L=1577]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.7e-17   61.7   0.3    1.3e-16   60.8   0.3    1.5  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.5e-07   31.6   0.6    1.1e-06   28.9   0.1    2.6  2  PAS_9          PAS domain
  ------ inclusion threshold ------
      0.024   14.1   0.1      0.062   12.7   0.1    1.7  1  HNOBA          Heme NO binding associated
      0.027   14.5   0.0      0.069   13.2   0.0    1.8  1  PAS            PAS fold
      0.049   13.7   0.0       0.12   12.4   0.0    1.7  1  PAS_8          PAS domain
      0.051   12.9   1.0       0.33   10.2   0.1    2.2  2  PFK            Phosphofructokinase
       0.11   12.7   2.1          4    7.8   0.2    2.9  2  Osmo_CC        Osmosensory transporter coiled coil
       0.68    9.9   3.2         15    5.6   0.6    3.4  2  CTK3           CTD kinase subunit gamma CTK3


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.8   0.3   5.8e-20   1.3e-16       3      64 ..    1515    1576 ..    1513    1577 .] 0.97

  Alignments for each domain:
  == domain 1  score: 60.8 bits;  conditional E-value: 5.8e-20
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvv 64  
                     ae++d++t +F+d+vgft++ss  +p e+v++Ln+l++ fde++++++++k+ktiGday ++
     EFC37886.1 1515 AEKFDDITCFFSDMVGFTKMSSTLQPTELVEMLNDLVNGFDEVCTKYNLEKIKTIGDAYFAA 1576
                     6899*******************************************************987 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.68   1.5e+03      35      60 ..     676     705 ..     649     757 .. 0.72
   2 !   28.9   0.1   4.7e-10   1.1e-06       2     103 ..    1368    1475 ..    1367    1476 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.68
       PAS_9  35 sitdlfvtdpeanerlraaleqgrk......k 60 
                 +      +++e+n+r+++a++ gr+       
  EFC37886.1 676 QAAV--LEEEEENNRKKQAFKGGRRgsravpG 705
                 3333..45999999999999999987777752 PP

  == domain 2  score: 28.9 bits;  conditional E-value: 4.7e-10
       PAS_9    2 dgilidnpdgril.yaNeaalrllG.yspeevlgksitdlfvtdpeanerlraaleqgrkkerevevvlirkng....etfwvlltaspvkdd.dge 91  
                  dg +i n +g i+  +N+ al ++G  s  +v+g+ +  lf +++  +++++++ ++  ++ +  ev+  r+ +    +tf+v+l+++  +++ + +
  EFC37886.1 1368 DGAVIFNQEG-IVeNINQVALSMFGiRSQSDVVGTEFYGLFQSKDVIAKTISDISKSANSHGEILEVEAKRSQNmlnsKTFPVRLNLCVAFSGgKSK 1463
                  6777877***.888***********999*************5555555555555555555999999999999999999************9994444 PP

       PAS_9   92 lvg.iivilrDit 103 
                      +++il D+t
  EFC37886.1 1464 K-VtFAGILSDVT 1475
                  4.459*******9 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1   2.8e-05     0.062     192     221 .]    1478    1507 ..    1471    1507 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2.8e-05
       HNOBA  192 eesmkeleeekkrtdeLLysmiPkevAerL 221 
                  ++s++ l+ ekk++++LL s+ P+ vA rL
  EFC37886.1 1478 KKSLELLNVEKKKSEDLLKSIFPEAVAARL 1507
                  578999*********************997 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   3.1e-05     0.069       2     107 ..    1358    1468 ..    1357    1474 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.1e-05
                  HHHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTH.HHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEE CS
         PAS    2 dlraileslpdpifvvDedgrilyvNaaaeellGlsr.eevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevra 93  
                  +l+ +l+s  d+ ++ +  g++  +N+ a +++G++  ++v+g  +++l+  +d  + + +     ++++++++ e+  k+     + ++++++++ 
  EFC37886.1 1358 MLKKVLDSCVDGAVIFNQEGIVENINQVALSMFGIRSqSDVVGTEFYGLFQSKD-VIAKTISDISKSANSHGEILEVEAKRsqnmLNSKTFPVRLNL 1453
                  6788999****************************999************8664.333333333333333333333333335566677777777777 PP

                  EEEEETTEEEE.EEE CS
         PAS   94 spvrdaggeil.gfl 107 
                  +  +++g+  +  f 
  EFC37886.1 1454 CVAFSGGKSKKvTFA 1468
                  766666665554555 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   5.5e-05      0.12       3      49 ..    1359    1403 ..    1357    1418 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 5.5e-05
       PAS_8    3 lralfesspdgiavvdlgdrivdvNqaalellGysadlkgellgqll 49  
                  l+ +++s  dg ++++  + +  +Nq al ++G +  +  +++g+ +
  EFC37886.1 1359 LKKVLDSCVDGAVIFNQEGIVENINQVALSMFGIR--SQSDVVGTEF 1403
                  7899************6663666**********77..5444444333 PP

>> PFK  Phosphofructokinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.1   0.00015      0.33      93     150 ..    1131    1184 ..    1093    1198 .. 0.73
   2 ?    0.4   0.1      0.14   3.2e+02     131     171 ..    1395    1434 ..    1364    1437 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00015
                  -EEEEEESHHHHHHHHHHHHT..T....--EEEEEEETT---TT-S--EEHHHHHHHH CS
         PFK   93 daLvviGGdgslkganklseerkglleelkivgiPkTidNDipgtdytiGfdTAlnti 150 
                  d+++v    +s kg n +++  ++    ++i +i  T +N++   + tiG++T  +t+
  EFC37886.1 1131 DNFLVFTRGDSQKGYNPIRSFSTD----IEILMISNTCSNNFTSINRTIGSNTTSTTL 1184
                  444444444566666666655444....*************************87765 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.14
                  T---TT-S--EEHHHHHHHHHHHHHHHHHHHHHHT-EEEEE CS
         PFK  131 dNDipgtdytiGfdTAlntiveaidklkstakshkrvfvvE 171 
                  + D++gt++  G   + ++i+++i +++++a+sh  +  vE
  EFC37886.1 1395 QSDVVGTEF-YGLFQSKDVIAKTISDISKSANSHGEILEVE 1434
                  578999994.78888999****************9887666 PP

>> Osmo_CC  Osmosensory transporter coiled coil
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.2    0.0018         4      20      42 ..     583     605 ..     581     607 .. 0.93
   2 ?    3.3   0.1     0.044        99      22      44 ..     720     749 ..     715     751 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0018
                 HHHHHHHHHHHHHHHHHHHHHH- CS
     Osmo_CC  20 kvedideeIaaLeekRqrLvdqH 42 
                 k e+id+ I +L +k+++L + H
  EFC37886.1 583 KAEEIDKKISQLYKKQTQLSNLH 605
                 779******************99 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.044
                 HHHHHHHHHHHH.......HHHHHHHH--- CS
     Osmo_CC  22 edideeIaaLee.......kRqrLvdqHPk 44 
                 +++ ee + Lee         ++L+++HP+
  EFC37886.1 720 DELPEEAECLEEenrkqkeGNKNLINKHPD 749
                 55667778888888654444578******8 PP

>> CTK3  CTD kinase subunit gamma CTK3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.6    0.0067        15       5      53 ..     636     687 ..     634     692 .. 0.86
   2 ?    2.5   0.1     0.062   1.4e+02      39      98 ..    1210    1271 ..    1187    1280 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0067
                 HHHHHHHHHHTT--SSGGGTHHHHHHHHHTG...GGHHHHHHHHHHHHHHS- CS
        CTK3   5 EvrsqFsqlLrkLtasvqslqkaaqfAlknk...dkeedlfscileqlesad 53 
                 E+rs F +l ++ ++sv+ l   + fA k     + +edl  ++le+ e+++
  EFC37886.1 636 ETRSMFEELFSQHSTSVTVLRNYSRFAEKFLfqpELAEDLQAAVLEEEEENN 687
                 99*************************8764222889*********988875 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.062
                  HHHHHHHHHHHHHS...-HHHHHHHHHHHHHHHHHHHHTT--S..THHHHHHHTHHHHHHHHS CS
        CTK3   39 edlfscileqlesa...dlNtranilyfidllleeslkegqsekspYveslkrdilklvdsvv 98  
                  edl+s il+ +e+    ++ +  +  yfi+++++  +  + s++ + v  +   +++++d++v
  EFC37886.1 1210 EDLMSYILSGMEQFkeeSFKNIRTSGYFIETFFKDHVSLSLSFR-AKVDKVLLVLVSVIDNIV 1271
                  67777776665554333665555557*********999999987.677777778888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1577 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1249  (0.0696637); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.81u 0.27s 00:00:01.08 Elapsed: 00:00:00.46
# Mc/sec: 10336.57
//
Query:       EFC37887.1  [L=119]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.9e-05   24.7   0.1    5.4e-05   23.8   0.1    1.4  1  Hemerythrin  Hemerythrin HHE cation binding domain


Domain annotation for each model (and alignments):
>> Hemerythrin  Hemerythrin HHE cation binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.1     3e-09   5.4e-05       5     124 ..      21     112 ..      18     118 .. 0.75

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 3e-09
                  HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH.CCC.HHHHHHHHHHHHHHHHHHHHHHHHCHTCGGSTC CS
  Hemerythrin   5 aldeeHralrallerlraladaaaevhgalrklaelldelvdeleaHhaaEEellfPlledrpggravldvlereHdeirelleelrellkgleepsa 102
                   l e+H++l+ l+++l    da        r + ++l+el d++  H++ EE+l+           ++ +++++ Hd + + + +l   + +      
   EFC37887.1  21 ELNEQHKKLFTLINAL----DA-------KRSCGTTLKELLDYVVFHFKTEEDLF-AKAG-----WSESASHKETHDKFVQDALALT-SVGD------ 94 
                  6889**********55....45.......57799********************5.4444.....6888899999999997664444.2222...... PP

                  HHHHHHHHHHHHHHHHHHHHHH CS
  Hemerythrin 103 aafaelleeladllreHiakEe 124
                       +++ + ++l  Hi+  +
   EFC37887.1  95 ----AEMQFIKQWLITHICASD 112
                  ....246777777777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.32s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 730.79
//
Query:       EFC37888.1  [L=370]
Description: hypothetical protein NAEGRDRAFT_74378 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-88  297.3   0.0    5.3e-88  295.4   0.0    1.7  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  295.4   0.0     3e-92   5.3e-88       3     405 ..       3     366 ..       1     368 [. 0.97

  Alignments for each domain:
  == domain 1  score: 295.4 bits;  conditional E-value: 3e-92
       Actin   3 evsavVlDnGssttraGyagedaPkavipslvgkprgrkvea....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeehpl 97 
                 +v++++lD Gs++++aG    d P ++i+s++g+++++ v++      yvg+ea+++r+ l +++p+++G+v+dwd+ e l+++++++elkvdp+e +l
  EFC37888.1   3 DVQSLILDIGSGSIKAGLHFHDEPSLIISSMIGRVKYKPVMMtnvkLGYVGNEAMRRRGILDISYPIRRGIVQDWDDLELLFQYIFESELKVDPHEFSL 101
                 799***********************************99999997789************************************************** PP

       Actin  98 lltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtp 196
                  l+++ lnp ++rek++E++fE+f++p+ly+  ++ ls+++sg+++g v+ sG++ + +v + +GyvL + irr++lgG +Lte+ ++ll++k      
  EFC37888.1 102 FLSDSLLNPDSNREKMVELLFETFGIPGLYFEYQPLLSLYSSGRTCGAVLHSGEGLSQIVSISNGYVLPQTIRRLNLGGFDLTEYSRKLLNTK------ 194
                 ********************************************************************************************8...... PP

       Actin 197 rylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesal 295
                                         ++ +k+ ++ e+++e+Ke++ ++s +      ++ +s e  YeLPDg++i++g+eRf++ E+LF+p+ +g +s  
  EFC37888.1 195 ------------------------GHCFKMKADFEIVRELKEKCARISLSND--DLQHIDSSELFYELPDGNRIEIGNERFEIGEALFNPQCLGIDSI- 266
                 ........................899********************99997..44555677888*******************************99. PP

       Actin 296 eeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEY 394
                         gi +l++++i++c++d +++++ ni++ GGns +p+ + R+ + +++ as+++kv+ +  +    ys WiG++ +  +++++ +w  ++ Y
  EFC37888.1 267 --------GIDQLLIDSIQKCEIDTQRDMFGNIILDGGNSRIPNYSTRIVNQVEKSASPSMKVRHVNMS--NEYSEWIGAAFMILHSQMNYMWYCREHY 355
                 ........***********************************************99999999988876..89************************** PP

       Actin 395 eEqGssvverk 405
                 +E G +++++ 
  EFC37888.1 356 DEFGTNFIHKH 366
                 *********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       369  (0.0205812); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2349.66
//
Query:       EFC37889.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.5e-29   98.7  19.5    4.7e-07   29.4   0.1    6.5  6  RCC1_2         Regulator of chromosome condensation (RCC1) re
    4.3e-23   81.7   9.2    9.9e-08   32.5   0.1    7.3  7  RCC1           Regulator of chromosome condensation (RCC1) re
  ------ inclusion threshold ------
       0.12   12.4   0.0       0.37   10.8   0.0    1.8  1  Ribonuc_L-PSP  Endoribonuclease L-PSP
       0.46   10.5   5.3       0.82    9.7   0.4    3.3  4  Kelch_5        Kelch motif
        1.6    9.2   3.9        2.3    8.6   0.3    3.1  4  Kelch_6        Kelch motif


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4   0.1   1.3e-10   4.7e-07       1      29 [.      38      66 ..      38      67 .. 0.94
   2 !   13.6   0.2   1.2e-05     0.044       7      30 .]      98     121 ..      94     121 .. 0.96
   3 !    9.1   0.0   0.00031       1.1       3      17 ..     148     162 ..     146     163 .. 0.92
   4 !   15.9   0.1   2.3e-06    0.0081       1      25 [.     193     217 ..     193     221 .. 0.94
   5 !   25.6   0.7   2.1e-09   7.6e-06       1      29 [.     236     264 ..     236     265 .. 0.93
   6 !   14.7   0.1   5.5e-06      0.02      11      30 .]     297     316 ..     293     316 .. 0.93

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 1.3e-10
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29
                +k+ ++G++ s++Lte++ ++c+G+Ns+G
  EFC37889.1 38 IKHAACGYRTSFFLTESDQLYCCGQNSSG 66
                67889**********************99 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 1.2e-05
      RCC1_2   7 GdyHscaLtedGeVlcWGsNsdGQ 30 
                 Gd ++++++ dG+ + +GsN+dGQ
  EFC37889.1  98 GDTFTFFIMKDGTFWRCGSNNDGQ 121
                 899********************9 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00031
      RCC1_2   3 svsaGdyHscaLted 17 
                 ++++G+yHs +L+++
  EFC37889.1 148 KIAFGYYHSAVLVNN 162
                 69**********997 PP

  == domain 4  score: 15.9 bits;  conditional E-value: 2.3e-06
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGs 25 
                 +++vs+G++ ++++ + G++++ G+
  EFC37889.1 193 IVDVSCGVFNTMVVNRRGHLYSIGQ 217
                 79********************998 PP

  == domain 5  score: 25.6 bits;  conditional E-value: 2.1e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 V ++ +G+   +a+t+ +eV+cWG+N++G
  EFC37889.1 236 VSKIFCGSLSGIAITSQDEVYCWGDNGSG 264
                 668999*********************99 PP

  == domain 6  score: 14.7 bits;  conditional E-value: 5.5e-06
      RCC1_2  11 scaLtedGeVlcWGsNsdGQ 30 
                 +++Lt++G Vl +G+Ns+ Q
  EFC37889.1 297 TIILTRSGQVLICGNNSNNQ 316
                 789**************998 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0019       6.8      25      50 .]      26      51 ..      11      51 .. 0.77
   2 !   16.9   0.0   2.1e-06    0.0074       2      50 .]      55     105 ..      54     105 .. 0.76
   3 !   32.5   0.1   2.8e-11   9.9e-08       1      50 []     108     159 ..     108     159 .. 0.90
   4 !    6.9   0.0    0.0028        10      35      50 .]     188     206 ..     172     206 .. 0.80
   5 ?    0.7   0.0      0.24   8.6e+02      35      44 ..     231     243 ..     217     249 .. 0.75
   6 !    6.2   0.1    0.0044        16       2      20 ..     253     271 ..     252     278 .. 0.80
   7 !    9.8   0.0   0.00034       1.2       1      17 [.     303     319 ..     303     344 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0019
                EEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1 25 vPtkveglsgnrvvkvacGddhtval 50
                vP + +++  +r++++acG++ +++l
  EFC37889.1 26 VPLEPSLFGYERIKHAACGYRTSFFL 51
                45555555545************986 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 2.1e-06
                 TEEEEEE--GGGTTSSSS---EEEE.....EE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgttesvlvP.....tkveglsgnrvvkvacGddhtval 50 
                 +++y++G+n+ G LG+gt+++   P     t+++      +  +  Gd +t+++
  EFC37889.1  55 DQLYCCGQNSSGELGNGTSVDY-EPlsknrTLIPHYG--TIETILGGDTFTFFI 105
                 689****************666.56543334444443..999999999999986 PP

  == domain 3  score: 32.5 bits;  conditional E-value: 2.8e-11
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgn..rvvkvacGddhtval 50 
                 dG  + +G+n++GqLG g++ + lvP  v++ +    rv k+a G++h+++l
  EFC37889.1 108 DGTFWRCGSNNDGQLGAGSKSKLLVPEPVNPTPWGahRVMKIAFGYYHSAVL 159
                 788899*******************999977666678************986 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0028
                 S...-EEEEEEETTEEEEE CS
        RCC1  35 n...rvvkvacGddhtval 50 
                 +   ++v+v+cG + t+++
  EFC37889.1 188 KmigEIVDVSCGVFNTMVV 206
                 35559***********986 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.24
                 S...-EEEEEEET CS
        RCC1  35 n...rvvkvacGd 44 
                 n   +v+k++cG+
  EFC37889.1 231 NidaPVSKIFCGS 243
                 14459*******7 PP

  == domain 6  score: 6.2 bits;  conditional E-value: 0.0044
                 TEEEEEE--GGGTTSSSS- CS
        RCC1   2 GrVysWGrndyGqLGlgtt 20 
                 ++Vy+WG n  G  G++++
  EFC37889.1 253 DEVYCWGDNGSGETGIPSS 271
                 58*******9998887766 PP

  == domain 7  score: 9.8 bits;  conditional E-value: 0.00034
                 TTEEEEEE--GGGTTSS CS
        RCC1   1 dGrVysWGrndyGqLGl 17 
                 +G+V+ +G+n+++qLG 
  EFC37889.1 303 SGQVLICGNNSNNQLGA 319
                 59**************7 PP

>> Ribonuc_L-PSP  Endoribonuclease L-PSP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0    0.0001      0.37       7      33 ..     150     176 ..     146     194 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0001
                    TSSS-BSEEEETTEEEEEEE-SB-TTT CS
  Ribonuc_L-PSP   7 aaapYsqavkagnlvyvsGqlpldpet 33 
                    a + Y +av ++n+vy+sG+l   + t
     EFC37889.1 150 AFGYYHSAVLVNNTVYISGKLSGSDTT 176
                    5678999*************9766533 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.5   5.4e+03       5      19 ..      37      59 ..      36      61 .. 0.55
   2 ?    9.7   0.4   0.00023      0.82       6      29 ..     153     177 ..     153     183 .. 0.82
   3 ?   -1.0   0.0      0.53   1.9e+03      11      21 ..     249     259 ..     238     271 .. 0.72
   4 ?    0.6   0.0      0.17     6e+02      15      30 ..     343     356 ..     336     363 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.5
     Kelch_5  5 Raghcavtv........sekiYv 19
                R  h+a+++        s+++Y+
  EFC37889.1 37 RIKHAACGYrtsfflteSDQLYC 59
                66777775533333333677776 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00023
     Kelch_5   6 aghcavtvsekiYvyGGkvg.rdgs 29 
                 ++h+av v++ +Y+ G  +g  + +
  EFC37889.1 153 YYHSAVLVNNTVYISGKLSGsDTTH 177
                 79***************99864444 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.53
     Kelch_5  11 vtvsekiYvyG 21 
                 +t  +++Y++G
  EFC37889.1 249 ITSQDEVYCWG 259
                 3445999*999 PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.17
     Kelch_5  15 ekiYvyGGkvgrdgsv 30 
                    +v+GG+++  ++v
  EFC37889.1 343 KTAFVTGGFQH--MIV 356
                 5589*****97..555 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.3   0.00065       2.3       3      18 ..     153     168 ..     151     180 .. 0.87
   2 ?   -1.4   0.0      0.93   3.3e+03       3      18 ..     200     216 ..     198     230 .. 0.80
   3 ?   -1.5   0.0         1   3.6e+03       5      18 ..     246     259 ..     243     273 .. 0.78
   4 ?   -3.9   0.0         5   1.8e+04      13      22 ..     344     353 ..     342     357 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00065
     Kelch_6   3 aghslvsvggkiYifG 18 
                 ++hs+v+v++++Yi G
  EFC37889.1 153 YYHSAVLVNNTVYISG 168
                 79************87 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.93
     Kelch_6   3 aghslvs.vggkiYifG 18 
                 +++++v+   g++Y +G
  EFC37889.1 200 VFNTMVVnRRGHLYSIG 216
                 67888776779999998 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1
     Kelch_6   5 hslvsvggkiYifG 18 
                 + +++ ++ +Y++G
  EFC37889.1 246 GIAITSQDEVYCWG 259
                 56788899999997 PP

  == domain 4  score: -3.9 bits;  conditional E-value: 5
     Kelch_6  13 kiYifGGytd 22 
                 + ++ GG  +
  EFC37889.1 344 TAFVTGGFQH 353
                 5689999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2500.80
//
Query:       EFC37890.1  [L=217]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.059   13.4   3.3       0.24   11.5   0.1    2.7  3  DUF1634   Protein of unknown function (DUF1634)
      0.073   11.0   0.1      0.096   10.6   0.1    1.1  1  Prominin  Prominin
       0.08   12.2   0.7      0.099   11.9   0.7    1.2  1  Tmpp129   Putative transmembrane protein precursor
       0.24   11.5   2.0       0.43   10.6   0.0    2.0  2  NPCC      Nuclear pore complex component
       0.33   11.0   4.2        1.2    9.3   0.1    2.2  2  DHHC      DHHC palmitoyltransferase


Domain annotation for each model (and alignments):
>> DUF1634  Protein of unknown function (DUF1634)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.3     0.088   3.2e+02      81     101 ..       2      22 ..       1      23 [. 0.91
   2 ?   11.5   0.1   6.7e-05      0.24      12      98 ..      48     136 ..      41     140 .. 0.78
   3 ?   -1.2   0.0       0.6   2.1e+03       8      25 ..     177     193 ..     163     214 .. 0.60

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.088
     DUF1634  81 ekdilyviitliVLliLllsl 101
                 e+ i++v  tl+ L+ Llls+
  EFC37890.1   2 ERSIMMVHATLFWLIFLLLSV 22 
                 8999**************997 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 6.7e-05
     DUF1634  12 saavvllGlilllvkhgssesenseltslseile..gllelkglaiiqlGllvLiatPvlrVvlsliaFlkekdilyviitliVLliLl 98 
                 s++++ l l+ +++ +++s+++++ + + +e  +  + ++ +g++ ++ Gl  L +  +     +l++F ++++++++++  + L+iL+
  EFC37890.1  48 SLVLINLLLMYYFFMQKRSYKKQALIKEKRERASsaANSNSEGTSSLTGGLSNLTLSNISNTTRKLFSFERKRNMFLIGVWWLLLTILF 136
                 5555556666677777768877777777776555124455668999999**********************************999996 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.6
     DUF1634   8 GvllsaavvllGlilllv 25 
                 Gv l ++ +l+G++++ +
  EFC37890.1 177 GVQL-MFPILIGTLVMRM 193
                 3333.2334455555544 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   2.7e-05     0.096     368     472 ..      73     182 ..      62     191 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 2.7e-05
    Prominin 368 lakgreqikklakkiprealdavisdle.nterssktfddvvekyekyrwliglivcsllllivvililgLlcGilGlsrtatptdrgcsknt.....G 460
                 ++++re  ++ a++  +e +++++  l+  t +++++ ++++  +e++r++  + v  lll i++ l++g + G+ Gls++++ +  + ++ +      
  EFC37890.1  73 IKEKRERASSAANSN-SEGTSSLTGGLSnLTLSNISNTTRKLFSFERKRNMFLIGVWWLLLTILFELFIGWIRGVDGLSESKDYSWLSYVSVMrwaksH 170
                 556666666666666.778888888888678999*********************************************99998765555433111113 PP

    Prominin 461 asfLlvgvglsF 472
                  ++L+vgv l F
  EFC37890.1 171 VVILIVGVQLMF 182
                 467777777777 PP

>> Tmpp129  Putative transmembrane protein precursor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.7   2.7e-05     0.099      43     135 ..       5     112 ..       1     144 [. 0.71

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.7e-05
     Tmpp129  43 tllvhsllplgYflgllllsk..vkaeelleletlwkvllllsvllailalvlv.vywsskkwsnhPiakelkklaeetssswrs............va 126
                  ++vh++l  + fl+l + ++   ++   +    lw++++++s l++i +l ++ + ++++++++  ++ke ++ a++  +s ++            ++
  EFC37890.1   5 IMMVHATLFWLIFLLLSVSNSflRESVYEPLAGELWSHIFATSSLVLINLLLMYyFFMQKRSYKKQALIKEKRERASSAANSNSEgtssltgglsnlTL 103
                 46889888888887888877776445556778899*******99777777777658999999*****99999888866644433344455555555555 PP

     Tmpp129 127 ssintefrr 135
                 s+i++  r+
  EFC37890.1 104 SNISNTTRK 112
                 555555554 PP

>> NPCC  Nuclear pore complex component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.5      0.18   6.3e+02      31      77 ..      13      60 ..       2     105 .. 0.57
   2 ?   10.6   0.0   0.00012      0.43      14     105 ..     111     209 ..      96     211 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.18
        NPCC 31 lllvfnlikklvklll.klyelkkksseeslasalyaelveklirllf 77
                ++l+f l++ + ++l  ++ye    +  ++++++  + l++ l+  +f
  EFC37890.1 13 FWLIFLLLSVSNSFLReSVYEPLAGELWSHIFATSSLVLINLLLMYYF 60
                444444443333333344444333333333444444444444433333 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00012
        NPCC  14 Rq.vnkErevkriiaNvllllvfnlikklvklll...klyelkkkss..eeslasalyaelveklirllfllniviallkLlrk.qdkiaDlpLtekQr 105
                 R+  + Er+  + +  v+ ll+  l++ ++  +     l+e k+ s   + s++++ ++++v+ ++ + +++ i+i  l +    + +i D +L+e Q 
  EFC37890.1 111 RKlFSFERKRNMFLIGVWWLLLTILFELFIGWIRgvdGLSESKDYSWlsYVSVMRWAKSHVVILIVGVQLMFPILIGTLVMRMDeKAEIVDRDLNELQH 209
                 4546668888888888888888888888888888555555544444488899999***********999*****9998888777789999999999885 PP

>> DHHC  DHHC palmitoyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.8      0.03   1.1e+02      67     116 ..      12      62 ..       4      79 .. 0.38
   2 ?    9.3   0.1   0.00032       1.2      48     115 ..     120     191 ..     106     212 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.03
        DHHC  67 vlllialvklveeekkseflavtllkkllsilllvls.llfllllgllllf 116
                 ++ li+l+  v+++   e  + +l  +l+s ++++ s +l+ lll++ +++
  EFC37890.1  12 LFWLIFLLLSVSNSFLRESVYEPLAGELWSHIFATSSlVLINLLLMYYFFM 62 
                 333333333333333333333333322222222222202222333333332 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00032
        DHHC  48 ykyFllfllylllllilalvlllialvklveeekkseflavtllkk....llsilllvlsllfllllgllll 115
                  ++Fl+ +++lll +++ l++ +i  v+ ++e+k  ++l +         +++il++ ++l+f +l+g l++
  EFC37890.1 120 RNMFLIGVWWLLLTILFELFIGWIRGVDGLSESKDYSWLSYVSVMRwaksHVVILIVGVQLMFPILIGTLVM 191
                 567999999999999999888887777777666666665554444466668888888888888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       871  (0.0485805); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.34s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 1312.13
//
Query:       EFC37891.1  [L=940]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-08   33.0   3.3    2.6e-07   31.0   3.3    2.0  1  UPF0489   UPF0489 domain


Domain annotation for each model (and alignments):
>> UPF0489  UPF0489 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   3.3   1.5e-11   2.6e-07       1     178 []     293     495 ..     293     495 .. 0.83

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 1.5e-11
     UPF0489   1 vvivesHheaLeaiyraigskklp..sdlslvHlDaHpDllipkkmsaddvfnallkil.eklaeelleelsidnwIlpavyaghi.srvvwikpawa. 94 
                 v +v +H +++ a + a +++ +p    l ++H+D+H    i ++ ++ +v++     + +k+  ++ +  +i+n+I +  y  ++  +vvw+++ w+ 
  EFC37891.1 293 VAVVNDHSQVMSALIVAKQERLVPshLSLPILHVDSHSGHKIIQHSKSLPVLDL----KkKKSITAIEKMTDINNFISTSQYYDLLgGHVVWVHNDWEg 387
                 679*********************4444557*******9999988888888887....434446666666788****88888887736*********** PP

     UPF0489  95 ...........................qqitegrkellvgkdres...irvdstedyflsdllyvp.eeeleelkqlelevleveeaslsekqdlilav 162
                                            +  ++ r ++  g+ ++    + vd++ +++ ++  +++ +e+l++ k ++++v+ +++ s+ ++q      
  EFC37891.1 388 shfamprgrhtavlakrsnakkgkpkiC-YKNMRGIFWDGTVSDLtfeTMVDENGKIYKNEKAVCTkSEKLKKQKHVRWDVYSMDQISRLNHQIF---- 481
                 *****************99999995531.23445556555555557779*********999999997888****************999999977.... PP

     UPF0489 163 leksksfildiDlDyF 178
                   ++ ++il +  D+F
  EFC37891.1 482 --NNTPYILHLNEDFF 495
                 ..9************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (940 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1318  (0.0735122); expected 358.6 (0.02)
Passed bias filter:                      592  (0.0330191); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.89u 0.32s 00:00:01.21 Elapsed: 00:00:00.52
# Mc/sec: 5473.57
//
Query:       EFC37892.1  [L=2442]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-38  129.0   1.1    1.1e-06   28.4   0.0    9.9  9  NHL           NHL repeat
    3.6e-09   36.6   7.2       0.27   10.8   0.0    7.3  9  SGL           SMP-30/Gluconolactonase/LRE-like region
    7.8e-08   32.6   2.0    2.8e-07   30.8   2.0    2.1  1  RGS           Regulator of G protein signaling domain
    5.1e-07   29.9  25.8    0.00048   20.4   6.5    2.7  2  EGF_2         EGF-like domain
    1.1e-06   29.1   6.0    2.9e-06   27.7   6.0    1.8  1  GPS           GPCR proteolysis site, GPS, motif
  ------ inclusion threshold ------
      0.076   12.9   0.0        1.9    8.3   0.0    2.6  2  Phytase-like  Esterase-like activity of phytase
       0.11   12.7   0.1         11    6.2   0.0    3.6  2  TGT_C2        Patch-forming domain C2 of tRNA-guanine transgl
       0.17   12.1   2.6        7.2    6.9   0.0    4.9  4  Arylesterase  Arylesterase
       0.46   10.6   5.6       0.13   12.3   0.7    2.8  1  K1            K1 glycoprotein
        3.1    6.9  16.7       0.75    9.0  12.9    1.8  1  Bac_export_2  FlhB HrpN YscU SpaS Family
        3.8    7.6  10.5        9.8    6.3   1.2    4.8  4  SBBP          Beta-propeller repeat
        8.7    6.7   9.6       0.51   10.6   0.2    3.7  2  DUF3082       Protein of unknown function (DUF3082)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0    0.0025       3.7       2      27 ..     340     365 ..     340     366 .. 0.93
   2 !   10.4   0.0   0.00037      0.55       1      25 [.     449     473 ..     449     474 .. 0.91
   3 !   14.7   0.0   1.5e-05     0.023       5      27 ..     563     585 ..     563     586 .. 0.95
   4 ?   -3.5   0.0       9.2   1.4e+04      16      26 ..     628     638 ..     627     639 .. 0.86
   5 ?   -0.2   0.0      0.83   1.2e+03      14      23 ..     739     748 ..     738     753 .. 0.80
   6 !   13.4   0.3     4e-05      0.06       3      26 ..     832     855 ..     832     855 .. 0.95
   7 !   20.9   0.0   1.7e-07   0.00026       1      27 [.     886     912 ..     886     913 .. 0.94
   8 !   28.4   0.0   7.3e-10   1.1e-06       1      27 [.     942     968 ..     942     969 .. 0.94
   9 !   19.6   0.0   4.4e-07   0.00066       1      27 [.     998    1025 ..     998    1026 .. 0.95

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0025
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n P +++++s+ di+  Ds+n+r+++
  EFC37892.1 340 NKPKSICITSDEDIIFIDSGNNRIRK 365
                 5799********************86 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00037
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 +++P++ a+d nG+i++aD++n  +
  EFC37892.1 449 LSFPRSAALDLNGNILIADFNNGKI 473
                 689*******************877 PP

  == domain 3  score: 14.7 bits;  conditional E-value: 1.5e-05
                 EEEEEETTTEEEEEECCCTEEEE CS
         NHL   5 hGvavdsnGdiyVaDsenhrvqv 27 
                 +G++v+++GdiyVa+s n+r+++
  EFC37892.1 563 WGLSVSPSGDIYVAESINSRIRK 585
                 8********************87 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 9.2
                 EEEECCCTEEE CS
         NHL  16 yVaDsenhrvq 26 
                 y aD +n rv+
  EFC37892.1 628 YLADAGNRRVR 638
                 89*****9997 PP

  == domain 5  score: -0.2 bits;  conditional E-value: 0.83
                 EEEEEECCCT CS
         NHL  14 diyVaDsenh 23 
                 d+y+aDs n+
  EFC37892.1 739 DLYIADSTNN 748
                 79****8876 PP

  == domain 6  score: 13.4 bits;  conditional E-value: 4e-05
                 SEEEEEEETTTEEEEEECCCTEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvq 26 
                 +P+++ v++nG iy +Ds nh+++
  EFC37892.1 832 NPTDIHVTNNGTIYLTDSLNHCIR 855
                 599*******************96 PP

  == domain 7  score: 20.9 bits;  conditional E-value: 1.7e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+++ v+s G+iyV+D+ nhrv++
  EFC37892.1 886 LNSPESLFVNSKGEIYVSDTVNHRVRK 912
                 799**********************97 PP

  == domain 8  score: 28.4 bits;  conditional E-value: 7.3e-10
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 ++yP G+ v++nGdiy+aD++nhr+++
  EFC37892.1 942 LSYPMGIYVSKNGDIYIADYGNHRIRK 968
                 689**********************86 PP

  == domain 9  score: 19.6 bits;  conditional E-value: 4.4e-07
                  BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL    1 fnyPhGvavd.snGdiyVaDsenhrvqv 27  
                  +n+P+Gv ++ + ++iy+aDs+n+ +++
  EFC37892.1  998 LNSPRGVYMSpNEDEIYIADSGNNLIRK 1025
                  799*********************9986 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       3.8   5.7e+03     130     160 ..     166     195 ..     124     200 .. 0.58
   2 ?    1.2   0.0      0.15   2.3e+02     129     166 ..     221     258 ..     212     264 .. 0.84
   3 ?   -2.0   0.0       1.4   2.1e+03     131     162 ..     337     367 ..     328     375 .. 0.79
   4 ?    1.9   0.0     0.096   1.4e+02     186     213 ..     452     479 ..     439     485 .. 0.85
   5 !    6.9   0.0    0.0027       4.1      97     212 ..     461     588 ..     456     595 .. 0.78
   6 ?   -0.6   0.0      0.53   7.9e+02      14      88 ..     627     700 ..     617     765 .. 0.55
   7 !   10.8   0.0   0.00018      0.27     145     218 ..     841     921 ..     836     928 .. 0.85
   8 ?    2.8   0.0     0.048        71     184     218 ..     943     977 ..     932     985 .. 0.86
   9 !   10.4   0.1   0.00023      0.35      93     167 ..     950    1032 ..     948    1045 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.8
         SGL 130 lddltipNGlawspdgktlYlaDsltrkiwa 160
                 +++++ip  l +s d++ +++aD+ + +i +
  EFC37892.1 166 ISSVNIPSSLIVS-DENEIFFADTFNYQIRK 195
                 4445555555444.55555567777766655 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.15
         SGL 129 vlddltipNGlawspdgktlYlaDsltrkiwaydvdae 166
                 v + ++   G+a++ +++ lY++D  +r+i  +++++e
  EFC37892.1 221 VDSPIGLVTGMALDFENRLLYYVDYDNRRIKMINLNDE 258
                 56677888899999999999999999999999988765 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1.4
         SGL 131 ddltipNGlawspdgktlYlaDsltrkiwayd 162
                  +++ p  +++++d++ ++ +Ds +++i ++ 
  EFC37892.1 337 AQINKPKSICITSDEDIIF-IDSGNNRIRKVL 367
                 5677788899999999765.9**999998875 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.096
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpd 213
                 p ++a+D +Gn+ +A +++gk+  +++ 
  EFC37892.1 452 PRSAALDLNGNILIADFNNGKIKLITNS 479
                 66899*****************999876 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0027
         SGL  97 GrlwfGtmgdeeakgeevgalyrldpd....gklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge........ 183
                 G++ + + ++++ k   + + y + ++    g+ +++ + +   NG ++s  +  +Y++Ds + ++ +   d    ++   + +  ++ ++        
  EFC37892.1 461 GNILIADFNNGKIKLITNSKSYTFAGSkatfGQENVIGTATRLYNGCGFSYYNGEFYWNDSGNCRVLKLGTDGIVRRIAGITGICGFSGDGglatnalm 559
                 55555555555555555555555555521223355666777889****************************999999999999999888889999999 PP

         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdp 212
                 g+  Gl v  +G ++vA   +++++++++
  EFC37892.1 560 GVSWGLSVSPSGDIYVAESINSRIRKISN 588
                 88999999999999999999999999875 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.53
         SGL  14 LlwvDilgqrihrldpatgketvldtpe..........svGaiaprkd.grlvvasksglalldlasgeletladeeedekpllrf 88 
                  ++ D  ++r+ +++ +tg  t++  ++            +ai+ + +   l v + +++++ d+++g+ ++              
  EFC37892.1 627 YYLADAGNRRVRKVSYSTGIITTIAGNGasgsseeninATSAIIGTSSpRALWVSNDDSVYYADVSNGKTRV------------VT 700
                 555666666666666666666665554422222222223333333333222223333333333444443333............33 PP

  == domain 7  score: 10.8 bits;  conditional E-value: 0.00018
         SGL 145 gktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge........gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 + t+Yl+Dsl+++i  +  d   + l +   +  +  ++        + p +l+v ++G+++v    +++v+++d +G++++
  EFC37892.1 841 NGTIYLTDSLNHCIRMITSDGVIS-LVAGSYYGGFGGDNgpaanavlNSPESLFVNSKGEIYVSDTVNHRVRKIDLNGTITT 921
                 6799**************998887.555555555555556799999977*****************************9875 PP

  == domain 8  score: 2.8 bits;  conditional E-value: 0.048
         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 ++p G+ v ++G +++A +g+++++++  +G++++
  EFC37892.1 943 SYPMGIYVSKNGDIYIADYGNHRIRKVFSNGTITT 977
                 56889*********************999999765 PP

  == domain 9  score: 10.4 bits;  conditional E-value: 0.00023
         SGL   93 vdpdGrlwfGtmgdeeakgeev.galyrldpdgk.......lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeg 167 
                  v+++G +++ + g+++ ++    g++  + + g+        e +l+ l+ p G+ +sp ++ +Y+aDs ++ i ++++d ++
  EFC37892.1  950 VSKNGDIYIADYGNHRIRKVFSnGTITTIAGTGSinyngdiQEATLTTLNSPRGVYMSPNEDEIYIADSGNNLIRKIKLDCPS 1032
                  789999999999988887774476666666665555666656778899*****************************999765 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   2.0   1.9e-10   2.8e-07       2      84 ..    2226    2319 ..    2225    2421 .. 0.85

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 1.9e-10
                  HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS........S CS
         RGS    2 leslledqpgrslFreFlesefseenlsFwlaveefkka...keqeelkkkakeIyneylapsspkelnidkklreelekrleke........q 84  
                  ++++l+++ g  lF+ F+e+efs enl ++ + +  ++    ++  +l++ ++ I+n+y+ ++s++e+ni+ k+r++     +++        q
  EFC37892.1 2226 MRDVLDKNEGYLLFEAFCEKEFSLENLYLYSDLKANETItkgRQFTNLTTFMRFIFNNYIRTGSTTEVNIPAKCRNNFLLVYKNVasssehmqQ 2319
                  5789*****************************99999944444455555599***********************998888776444444440 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7  11.3   2.1e-05     0.031       5      32 .]    1057    1083 ..    1049    1083 .. 0.89
   2 !   20.4   6.5   3.2e-07   0.00048       7      32 .]    1098    1122 ..    1095    1122 .. 0.94

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2.1e-05
       EGF_2    5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32  
                  ++ C+g+G+Cv   G C C ++ ++G++C
  EFC37892.1 1057 NSVCSGNGQCV--DGSCICnNQTFTGPNC 1083
                  789********..******888889**** PP

  == domain 2  score: 20.4 bits;  conditional E-value: 3.2e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G+Cv+++ +C+C sgy G+ C
  EFC37892.1 1098 VCSGNGQCVTAN-NCSCLSGYVGNEC 1122
                  5********888.8************ PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   6.0   1.9e-09   2.9e-06       2      43 ..    1800    1839 ..    1799    1841 .. 0.81

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 1.9e-09
         GPS    2 sCvfWdeeneetgsWsteGCel.tesdnknetvCsCnHLtsFA 43  
                  sC +Wde+n   + Ws++GC+l    +n   + CsC+H+t F+
  EFC37892.1 1800 SCRYWDETN---KIWSDRGCQLsNIDLNAGTVECSCSHTTMFT 1839
                  8****7555...99******9964444777778*******996 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.0    0.0013       1.9      68     101 ..     886     920 ..     793     926 .. 0.82
   2 ?    1.5   0.0      0.16   2.4e+02      72     101 ..     947     976 ..     945    1016 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0013
  Phytase-like  68 l.DpEgiavapdgtfwvssEggpfilefdadGkll 101
                   l  pE++ v+++g+++vs+  +++++++d++G+++
    EFC37892.1 886 LnSPESLFVNSKGEIYVSDTVNHRVRKIDLNGTIT 920
                   3579****************************986 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.16
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkll 101
                   gi v+++g++++++ g+++i+++  +G+++
    EFC37892.1 947 GIYVSKNGDIYIADYGNHRIRKVFSNGTIT 976
                   78999******************9999984 PP

>> TGT_C2  Patch-forming domain C2 of tRNA-guanine transglycosylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.22   3.3e+02      24      52 ..      75     100 ..      63     109 .. 0.80
   2 ?    6.2   0.0    0.0076        11      22      54 ..     351     383 ..     344     384 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.22
      TGT_C2  24 vtitrsatgrirqvlvdgerlatlraqdg 52 
                 + i    ++rir ++  ++ ++t+ a +g
  EFC37892.1  75 LFIV--ESNRIRRIFSSNNTIVTI-AGNG 100
                 5556..899**************8.5555 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0076
      TGT_C2  22 edvtitrsatgrirqvlvdgerlatlraqdgrl 54 
                 ed+ +  s  +rir+vl+ +e l t+ +q+  +
  EFC37892.1 351 EDIIFIDSGNNRIRKVLHSNETLITISGQNTSF 383
                 5677777899****************9999776 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       3.7   5.5e+03      48      72 ..     334     358 ..     325     366 .. 0.83
   2 ?   -1.8   0.0       2.5   3.8e+03      48      78 ..     825     854 ..     822     858 .. 0.79
   3 ?   -0.0   0.0       0.7   1.1e+03      51      78 ..     940     966 ..     926     971 .. 0.80
   4 ?    6.9   0.0    0.0048       7.2      36      78 ..     981    1023 ..     974    1029 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.7
  Arylesterase  48 vvasglssanGInidadkkyiyvad 72 
                     +++++ +  I i +d+ +i++ +
    EFC37892.1 334 ATIAQINKPKSICITSDEDIIFIDS 358
                   5678899999************965 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2.5
  Arylesterase  48 vvasglssanGInidadkkyiyvadilresi 78 
                   +++  l+ ++ I +  +   iy++d+l++ i
    EFC37892.1 825 QAIYALINPTDIHVTNN-GTIYLTDSLNHCI 854
                   56777888999998765.589******9987 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.7
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   ++ls + GI ++ +   iy+ad  ++ i
    EFC37892.1 940 AKLSYPMGIYVSKN-GDIYIADYGNHRI 966
                   46899****98865.579****998887 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0048
  Arylesterase   36 tavvYyspsevkvvasglssanGInidadkkyiyvadilresi 78  
                    t+ + y+++  +     l+s+ G+ +++++  iy+ad+ ++ i
    EFC37892.1  981 TGSINYNGDIQEATLTTLNSPRGVYMSPNEDEIYIADSGNNLI 1023
                    56677888888889999********************987766 PP

>> K1  K1 glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.7     9e-05      0.13      17      71 ..    1819    1878 ..    1807    1889 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 9e-05
          K1   17 anitpethtv..svssttgfrtfa...taptlfvmkevkstylyiqehllvfmtlvalig 71  
                  +ni  ++ tv  s s tt f tf    t+  ++ mke  +t  ++q  l  + t+val+ 
  EFC37892.1 1819 SNIDLNAGTVecSCSHTTMFTTFVeqkTTSIMIAMKEEVATLYFVQIALGAVYTIVALVI 1878
                  4555444444228899*******73335556788999999*****************974 PP

>> Bac_export_2  FlhB HrpN YscU SpaS Family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0  12.9    0.0005      0.75      45     199 ..    1918    2071 ..    1884    2076 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0005
                    XXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Bac_export_2   45 pslveelaellrevlsa.....lelllelllallllllplllvlllaallanllqv.gflfstkalkpklsklnplkglkrifslrslvellksl 133 
                    + lv++       +ls+      e+  +++  ++  +++++ +l l+a l  ++qv +f f  +  k+  ++ + +++  +i+++ +l+   k +
    EFC37892.1 1918 SVLVSQ-------LLSTtdpkvWEVGDNAANIIANSVAIVVNTLNLTATLCYVMQVsRFQFLKHLYKLLSDNRSDMAKNAKILKVLKLITSQKIF 2005
                    222222.......222244455556678888888889999999999999999999977888777777777766777777799************* PP

                    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Bac_export_2  134 lkvvlvgavaylvlkseleellalaeldleaalelllslllkllllvllallviallDlllqrwef 199 
                    + +++++av+ ++++  +  l++++ +d+++   ++ s  + ++l++ ++++++a++D+++   ++
    EFC37892.1 2006 FSIIAIFAVLNVCFWTLWVVLVRTQVIDASTYTYIVSSCYITCILFFGAVICIVAIADWIISTKKH 2071
                    ************************************************************998877 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.039        58       7      29 ..     444     466 ..     437     466 .. 0.89
   2 ?   -1.3   0.0       1.5   2.3e+03      17      29 ..     564     576 ..     564     581 .. 0.83
   3 ?   -2.4   0.5       3.5   5.2e+03      28      38 .]     761     770 ..     761     770 .. 0.90
   4 ?    6.3   1.2    0.0066       9.8      10      29 ..     939     959 ..     929     966 .. 0.79

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.039
        SBBP   7 GgpgastygngIavDsnGNiYvt 29 
                  ++++  ++++ a D nGNi ++
  EFC37892.1 444 ATSSYLSFPRSAALDLNGNILIA 466
                 5789999*************986 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.5
        SBBP  17 gIavDsnGNiYvt 29 
                 g+ v ++G iYv+
  EFC37892.1 564 GLSVSPSGDIYVA 576
                 678999******8 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 3.5
        SBBP  28 vtGsTngnnfe 38 
                 v+G+ n+ nf+
  EFC37892.1 761 VAGTGNA-NFN 770
                 89*****.996 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0066
        SBBP  10 gast.ygngIavDsnGNiYvt 29 
                 +a++ y+ gI+v +nG iY++
  EFC37892.1 939 NAKLsYPMGIYVSKNGDIYIA 959
                 44444999************8 PP

>> DUF3082  Protein of unknown function (DUF3082)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.2   0.00034      0.51      39      70 ..     406     437 ..     387     438 .. 0.85
   2 ?   -0.3   0.0      0.86   1.3e+03      38      63 ..     571     596 ..     562     602 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00034
     DUF3082  39 dnqlvqriavavRtlvvGlcyLatfvfgival 70 
                 +n +++  +++vR++v+G+++++++v+g  ++
  EFC37892.1 406 ENKTIITESTIVRQVVNGVISIVAGVYGSFGV 437
                 69999999*******************97765 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.86
     DUF3082  38 sdnqlvqriavavRtlvvGlcyLatf 63 
                  d +++ +i + +R + +G+++ +++
  EFC37892.1 571 GDIYVAESINSRIRKISNGIITTVAG 596
                 46899***************987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2442 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1420  (0.0792013); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 1.35u 0.38s 00:00:01.73 Elapsed: 00:00:00.57
# Mc/sec: 12827.52
//
Query:       EFC37893.1  [L=829]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-08   35.1   4.3    1.7e-08   34.8   1.1    2.8  2  RGS             Regulator of G protein signaling domain
    1.7e-08   34.8   0.2    4.9e-08   33.3   0.1    1.9  2  CHASE4          CHASE4 domain
  ------ inclusion threshold ------
      0.044   13.6   0.0       0.14   12.0   0.0    1.9  1  Qua1            Qua1 domain
      0.057   13.1   1.8       0.44   10.2   0.4    2.3  2  Tetraspanin     Tetraspanin family
       0.17   12.0   0.0       0.42   10.7   0.0    1.6  1  DUF4267         Domain of unknown function (DUF4267)
       0.25   11.8   5.0        1.5    9.4   0.1    3.1  3  Pox_H7          Late protein H7
        2.9    8.7   9.7       0.18   12.6   1.4    2.9  3  KMP11           Kinetoplastid membrane protein 11


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1      0.81   2.1e+03      43      43 ..     200     200 ..     167     253 .. 0.55
   2 !   34.8   1.1   6.5e-12   1.7e-08       1     109 [.     709     819 ..     709     826 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.81
                 H CS
         RGS  43 q 43 
                  
  EFC37893.1 200 A 200
                 1 PP

  == domain 2  score: 34.8 bits;  conditional E-value: 6.5e-12
                 -HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-H..HHHHHHHHHHCSSSTTTTTTHHHHHHH CS
         RGS   1 sleslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidk..klreelekrlekeqpsrklfeeaqeev 97 
                 ++e+++++ + r+ F++F+ ++ +  n++F  +v ++k+++   ++ +k  eI +++l ++sp  lni     ++ e+ek l++e+p+ +lf+ + +  
  EFC37893.1 709 KFEKMINNTKKRRKFQKFCSEKGQLYNFKFIREVRDYKTTELPIDRARKQSEICSNFLRKDSPFPLNIGAidLIKGEIEKILKEETPQISLFDGLNDIL 807
                 5899****************************************************************85326889*********************** PP

                 HHHHHHHHHHHH CS
         RGS  98 fellekdsypkF 109
                  ++l+++ ++ +
  EFC37893.1 808 ESILKSEVFTLY 819
                 ****99999876 PP

>> CHASE4  CHASE4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.1   1.9e-11   4.9e-08       5     119 ..     190     350 ..     186     356 .. 0.77
   2 ?   -2.9   0.0       2.9   7.5e+03      49      66 ..     585     602 ..     581     655 .. 0.60

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 1.9e-11
      CHASE4   5 eldqlerllkdwavWDdtyafvqd.rdpd............yiesnlgdetletlgldlvlfldadgklvydqengq...............ekllsea 75 
                 e+ +  ++ + +avWD+ y++ q+  dp             ++e+n+++  +   +++++lf++ +g+l+   +++                +      
  EFC37893.1 190 EFVNSLEIMQAVAVWDEPYKLFQRyYDPSenqtelavdmqlFLETNIDSAQMLLEKHNYALFYTLNGTLIA-SRAHNlidesqdlsdlskipK------ 281
                 56666778999*************99*99*****************************************5.333336666555555555550...... PP

      CHASE4  76 eee..................s.grsgllkldggp......alvaaapIlts..egegpsrGtlvfgryld 119
                   e                    +  g+lk+ +g+      ++++a p+  s  +++ p +G++v gr+++
  EFC37893.1 282 --EllelnvnsnplfrnadkaGtSNGGFLKVSNGVvenskiVMLVAKPVSPSnfNENNPTSGLIVYGRHVT 350
                 ..144445555556666655425777888777777777777********55534888***********987 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.9
      CHASE4  49 dlvlfldadgklvydqen 66 
                 d+v++++ d  lv + +n
  EFC37893.1 585 DVVFIVNGDSGLVLNANN 602
                 678888888888862222 PP

>> Qua1  Qua1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   5.6e-05      0.14       9      37 ..     767     795 ..     765     797 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 5.6e-05
        Qua1   9 ekdSLdPsfthamqLlsaEIekiqkgesk 37 
                 +kdS +P  + a+ L++ EIeki k+e+ 
  EFC37893.1 767 RKDSPFPLNIGAIDLIKGEIEKILKEETP 795
                 89************************985 PP

>> Tetraspanin  Tetraspanin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.4   0.00017      0.44      67     126 ..     132     191 ..     129     212 .. 0.81
   2 ?    1.6   0.0     0.072   1.8e+02      86     104 ..     468     487 ..     444     638 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00017
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--HHH........HHHHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Tetraspanin  67 Gcigalkenkcllltfsllllvlfllelaagilgfvfsdkargkvseiinnaievkyrdd 126
                   c+g+l+ +++++lt ++ +++l+++ ++  i++  + + +rg+ +  +++ +++ y++ 
   EFC37893.1 132 SCCGTLRWSTVMILTAVFSIMILLFVAIISSIIVTSYDELERGNSKADMKRVVKSFYDEF 191
                  6*********99999999888888888888998888888889998888888887776654 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.072
                  XXXXXXXXXXXXX.XXX--H CS
                  xxxxxxxxxxxxx.xxxxxx RF
  Tetraspanin  86 llvlfllelaagi.lgfvfs 104
                   l++f + +aa++ ++fv +
   EFC37893.1 468 ALLVFSCIIAAIViIAFVER 487
                  22223333333332333333 PP

>> DUF4267  Domain of unknown function (DUF4267)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00016      0.42      35      59 ..     450     474 ..     413     493 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00016
     DUF4267  35 aanalialkGvRdlalGlallvlsl 59 
                   +  i+l+GvR lal++allv+s+
  EFC37893.1 450 DTERNIYLLGVRSLALSIALLVFSC 474
                 56778******************97 PP

>> Pox_H7  Late protein H7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1       1.9   4.8e+03      92     118 ..      82     108 ..      58     116 .. 0.73
   2 ?    9.4   0.1   0.00057       1.5      62     115 ..     522     574 ..     517     586 .. 0.80
   3 ?    3.2   0.2     0.046   1.2e+02      88     115 ..     703     730 ..     698     749 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.9
                 HH-HHHHHHH-HHHHHHHHHHT--XXX CS
      Pox_H7  92 lediedyikeskklkrvikvyktkkrk 118
                 ++++++  ++ kk  +++++y++ k++
  EFC37893.1  82 MKEMDEMFRTNKKKSKFAHLYQSNKKQ 108
                 357778888888889999999764444 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00057
                 GT---EE--HHHHHHTHHHHHHHHHHHHHHHH-HHHHHHH-HHHHHHH.HHHT-.- CS
      Pox_H7  62 lnaklkkltpdeyaahsaaiakeltaadiilediedyikeskklkrvi.kvykt.k 115
                 +na+ ++l  de+ + ++ i + lt  di+le+     ke+k l++++ +vy + +
  EFC37893.1 522 INASERNLIFDEIDTTAKYINEMLTSLDIVLEE---QLKEQKMLRKLLeRVYTAeE 574
                 789999**************************9...67888888887646774433 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.046
                 HHHHHH-HHHHHHH-HHHHHHHHHHT-- CS
      Pox_H7  88 adiilediedyikeskklkrvikvyktk 115
                  +ii+e  e+ i+++kk +++ k++  k
  EFC37893.1 703 QEIINEKFEKMINNTKKRRKFQKFCSEK 730
                 689*********************9443 PP

>> KMP11  Kinetoplastid membrane protein 11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.4      0.54   1.4e+03      56      85 ..      72     106 ..      53     111 .. 0.69
   2 ?   -2.8   0.0       4.4   1.1e+04      47      58 ..     604     615 ..     592     642 .. 0.56
   3 ?   12.6   1.4   7.1e-05      0.18      29      88 ..     688     749 ..     663     751 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.54
       KMP11  56 kehtekfnkkmrehsehf.....kakfaelleqqk 85 
                 +e t+ +   m+e  e f     k+kfa l + +k
  EFC37893.1  72 EEETNSIILEMKEMDEMFrtnkkKSKFAHLYQSNK 106
                 56677777777777777644433568888877666 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 4.4
       KMP11  47 hyekfekmikeh 58 
                  ye++e+ + e 
  EFC37893.1 604 FYEQMERSVMEV 615
                 444444444443 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 7.1e-05
       KMP11  29 kffadkpdeatlspemkehyekfekmike..htekfnkkmrehsehfkakfaelleqqkaaq 88 
                  f+a k d  +l  +     ekfekmi++  +  kf+k   e+ + ++ kf   + + k+++
  EFC37893.1 688 LFMAKKDDSLSLGIDQEIINEKFEKMINNtkKRRKFQKFCSEKGQLYNFKFIREVRDYKTTE 749
                 37788888889999999999*******97224579**********9*999988777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (829 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1732  (0.0966033); expected 358.6 (0.02)
Passed bias filter:                      686  (0.038262); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.93u 0.34s 00:00:01.27 Elapsed: 00:00:00.55
# Mc/sec: 4548.10
//
Query:       EFC37894.1  [L=528]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.9e-55  187.3   3.1    5.8e-55  186.7   3.1    1.2  1  Peptidase_C1    Papain family cysteine protease
    1.5e-37  128.6   0.4    2.6e-37  127.7   0.4    1.4  1  CathepsinC_exc  Cathepsin C exclusion domain
    0.00062   18.7   1.1     0.0015   17.3   0.1    2.0  2  Peptidase_C1_2  Peptidase C1-like family


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  186.7   3.1   9.6e-59   5.8e-55       1     217 [.     294     523 ..     294     524 .. 0.86

  Alignments for each domain:
  == domain 1  score: 186.7 bits;  conditional E-value: 9.6e-59
                   STSCEETTTTTTG..SG---B-TSSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS--SSS CS
  Peptidase_C1   1 lpesvDwrekgga..vtpvkdqgsCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdypYkak 94 
                   +p+++Dwr+ +g+  v+p++ qg+CGsC++fs+++++e+r  + t+ k++   S +++++Cs   ++gC+GG+     ++ ++ gi  e++ pY+++
    EFC37894.1 294 IPKAFDWRNVNGQdfVSPIRSQGQCGSCYSFSTTAMMEARKRVFTQnKEQPVYSPENIISCSF-YSQGCDGGFAYLISKWGEDFGIIAEQCDPYTGT 389
                   69*******555558***********************99988887799************96.89******************************9 PP

                   CSSS-CGCGGGSE..EBEESEEEEEESS..BHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCET.........SS-EEEEEEEEEEEET. CS
  Peptidase_C1  95 eggkCkkkkkkek..vakikgygkvken..seealkkalakngPvsvaidaseedfqlYksGvyketecsk.........telnhavlivGygven. 177
                     +kC+ ++  ++  +++  +y+   +   + e+++  + k+gP+sv++++++ d+ +Y+sG+y++ + sk         + +nh vlivG+g+++ 
    EFC37894.1 390 P-HKCNLNQACSTrqYWTNYRYTGGYYGavTVENMQLDVLKYGPLSVSMEVYN-DLFNYHSGIYRHVSSSKltspvpnpfELTNHVVLIVGWGENEk 484
                   9.6899884444424444444444333356789********************.6***********94444444778787789**********9776 PP

                   TEEEEEEE-SBTTTSTBTTEEEEESSSSTGGGTTSSEEEE CS
  Peptidase_C1 178 gkkyWivkNsWgtdwgekGYiriargknnecgieseavap 217
                   g+kyWivkNsWgt++g++GY+ iarg++ ec iese  ++
    EFC37894.1 485 GEKYWIVKNSWGTSFGMDGYFLIARGVD-ECAIESENASA 523
                   9**************************9.*****998765 PP

>> CathepsinC_exc  Cathepsin C exclusion domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  127.7   0.4   4.4e-41   2.6e-37       1     121 []      31     161 ..      31     161 .. 0.92

  Alignments for each domain:
  == domain 1  score: 127.7 bits;  conditional E-value: 4.4e-41
  CathepsinC_exc   1 dlpvnClyediv.GkWkfevsek...gedksvkCskevpdkakaskkvevelkkpnvvvdekknkgkwtliYdqGfevelnkrkyfaffkykkeg 91 
                     dlpv+Cly++++ G W+fe++++   g+d ++kC+  +++ ++a+++++v l++p++++dek+n+g++tl+YdqGfev++ ++ky+aff+y+++g
      EFC37894.1  31 DLPVHCLYNSTApGVWEFELTDQnmsGDDVAAKCD--IRAPIQATRTMKVYLQMPDIAIDEKGNTGFFTLVYDQGFEVVVGGNKYWAFFNYTTAG 123
                     89*******9988*********988889999****..77778**************************************************999 PP

  CathepsinC_exc  92 sk......vtsyCnetlvgwvhd..vlgknwaCfkgkk 121
                     ++      ++s+C++t++gw+h+  v++k+w+C+++++
      EFC37894.1 124 KDsqgndiIISNCDRTFTGWYHEakVKAKSWGCYRARR 161
                     5445677799*************7788899*****975 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.2       0.1     6e+02      57      77 ..     311     331 ..     300     343 .. 0.80
   2 !   17.3   0.1   2.6e-07    0.0015     357     398 ..     468     508 ..     438     512 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.1
                     S--B--BSSTHHHHHHHHHHH CS
  Peptidase_C1_2  57 evtnqkqsGRCWlFaalnvlR 77 
                     ++  q q G C+ F+++ ++ 
      EFC37894.1 311 PIRSQGQCGSCYSFSTTAMME 331
                     677899*********998874 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 2.6e-07
                     ----EEEEEEEEEE-TTSSEEEEEEE-SBTTTSTBTTEEEEE CS
  Peptidase_C1_2 357 slmtHamvltgvdvdddgkvtkwkvEnsWGedsGekGyfvms 398
                      l +H ++++g  ++++g  + w v nsWG   G +Gyf ++
      EFC37894.1 468 ELTNHVVLIVGWGENEKG-EKYWIVKNSWGTSFGMDGYFLIA 508
                     5789*********95555.578*****************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (528 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       560  (0.0312343); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2869.94
//
Query:       EFC37895.1  [L=395]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.6e-31  109.4   0.0    2.9e-31  109.3   0.0    1.1  1  Amino_oxidase  Flavin containing amine oxidoreductase


Domain annotation for each model (and alignments):
>> Amino_oxidase  Flavin containing amine oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.3   0.0   1.6e-35   2.9e-31     210     452 .]     135     384 ..      37     384 .. 0.82

  Alignments for each domain:
  == domain 1  score: 109.3 bits;  conditional E-value: 1.6e-35
                    HHHHHHHHHTTTTEEEETSEEEEEEEEETTCEEEEETTSTEEEESEEEE-S-HHHHH..SSEEESCCSHHHHHHHHHS.EEEEEEEEEEEESSGGS CS
  Amino_oxidase 210 sqlpealaeelrgldirlntrVkeikregdgvtvtledgevveaDaVvvTvplgvlk..ailfsPplpdekaeairnl.gfgsvnkvilefdrkfw 302
                    ++l+ +l++ +++++i+ln  V +i++++  +++   +g ++++D++++Tvpl +l+   i+f+P+l++ +   i+n  ++ + +k+il f+++fw
     EFC37895.1 135 HSLIPYLTKNIKKNQIKLNYIVQSIDYSSKLIKI---NGGEITCDKIILTVPLTTLRnrLIQFTPELSPLRKHLIQNQfHMHGGCKIILGFKKPFW 227
                    45666677799****************8888888...8999**************************778888888877***************** PP

                    GCSTSECE.CECCCEEETTTEEEEECC.ECCCSTTTEEEEEEEEECHHHHHHHTTS-HHHHHHHHHHHHHHHHT..GTSSTCSEEEEEECCTETTT CS
  Amino_oxidase 303 ednalgqg.vlvseltttlgeafissd.fpsrappgkglvllvyvggdaaneleslsdeelvqavlrdLrklfg..eevpepkatlvtrWhtdpla 394
                    +d++  +    v+ +  ++    ++++  +  +++  g++++ + + ++a+    l +ee+++++++ ++k f   ++++  + + +++W+++ + 
     EFC37895.1 228 KDQI--PNvNVVCVGDQDPLISQFWFSsTSKEQTEKYGHIITGFSMSNRADNGLILGEEEIKDHFRKFIQKTFDlnDKNDGFIGGKIRNWQDVQHV 321
                    **55..23445555555555555555547777777777799999998888887789******************8888888999************ PP

                    SSSEEE.BTTH.HHHHHHHHHCH....HCSTTEEE.SGGGCTTTTTSHHHHHHHHHHHHHHHH CS
  Amino_oxidase 395 rgsysyvsvgp.ghedydplakp....egdprlffAGehtsreypgtvegAilSGlraAaril 452
                     g+ys+ ++   +++ y +  +       d+ l+fAGe  + + p+t++gA+++G+ aA r++
     EFC37895.1 322 AGAYSFAYTSDsSRRNYIKNPRVllsqPIDSKLYFAGELYCAHSPATIHGAMETGRDAALRLI 384
                    ****776665554445554444467766999****************************8775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (395 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.36s 00:00:01.06 Elapsed: 00:00:00.57
# Mc/sec: 2101.83
//
Query:       EFC37896.1  [L=304]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       596  (0.0332422); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.37s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 1701.69
//
Query:       EFC37897.1  [L=489]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0073   16.1   0.9      0.018   14.9   0.1    2.1  2  HECW_N    N-terminal domain of E3 ubiquitin-protein ligase HE


Domain annotation for each model (and alignments):
>> HECW_N  N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1      0.34   6.1e+03      55      80 ..      68      93 ..      65     105 .. 0.70
   2 !   14.9   0.1   9.9e-07     0.018      87     118 ..     202     233 ..     192     235 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.34
      HECW_N 55 etnsenfldyknrgvngtrkGqivwk 80
                +tn++n+++y+n g    ++G ++  
  EFC37897.1 68 DTNNNNYVNYNNDGEMYNNNGGYSIL 93
                67788999999988877777766654 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 9.9e-07
      HECW_N  87 fteaetkiCFkYYhgvsgaLrAttpsitvknp 118
                 f+++  + CF+Y  +++g Lr t p i+v ++
  EFC37897.1 202 FESTYEHTCFQYLDSTTGRLRRTCPLINVVDS 233
                 55667789*********************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1045  (0.0582855); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 2893.23
//
Query:       EFC37898.1  [L=773]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (773 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1376  (0.0767472); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.76u 0.35s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 4538.72
//
Query:       EFC37899.1  [L=527]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0062   17.0   1.0      0.022   15.2   0.2    2.5  2  DUF2779   Domain of unknown function(DUF2779)
  ------ inclusion threshold ------
      0.045   14.0   0.0       0.11   12.8   0.0    1.6  1  SseB      SseB protein N-terminal domain


Domain annotation for each model (and alignments):
>> DUF2779  Domain of unknown function(DUF2779)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.2   2.5e-06     0.022      12      88 ..      90     183 ..      82     287 .. 0.81
   2 ?   -3.5   0.0       1.6   1.4e+04      17      34 ..     378     395 ..     373     426 .. 0.56

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.5e-06
     DUF2779  12 lPpfdgtkpYqqipfqfSlhilqeegevehkeflaespntdpreelieeLikiiekegsvvvynksfEksrlkela....................q 88 
                 lP fd ++  q++ f   l+i+ e+ +++ k   +  ++   ++  + eLik ie++gsv+++n+s E s lk+                      +
  EFC37899.1  90 LPIFDSEVICQKLQF---LDIFCESMKIKGKPLYHIRDVFSLCNTYLYELIKGIEQDGSVIIHNNSLEYSFLKQFScvvseneellpvfssheylkS 183
                 666666666666655...677777777788877787778888999999***************************9555555544444444444443 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.6
     DUF2779  17 gtkpYqqipfqfSlhilq 34 
                  +k Y+ +++ +Sl+  +
  EFC37899.1 378 SSKKYSTVVMPVSLQLNS 395
                 567777788777776532 PP

>> SseB  SseB protein N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   1.2e-05      0.11      60     107 ..     166     216 ..     141     223 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.2e-05
        SseB  60 edgrralpvFTsaeelkkwaadarpvavvlpfaalaallega...eaeglv 107
                 ++++  lpvF+s e lk w ++++ + ++ ++++ ++ + ++   +  g++
  EFC37899.1 166 SENEELLPVFSSHEYLKSWFSKKQKELLEWKVDETFQHTTEEyqdDQLGIL 216
                 456789**************************9999988887766666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (527 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       997  (0.0556082); expected 358.6 (0.02)
Passed bias filter:                      519  (0.0289475); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.26s 00:00:00.89 Elapsed: 00:00:00.45
# Mc/sec: 3556.45
//
Query:       EFC37900.1  [L=952]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (952 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1435  (0.0800379); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.80u 0.28s 00:00:01.08 Elapsed: 00:00:00.47
# Mc/sec: 6118.14
//
Query:       EFC37901.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.3e-34  115.1   5.8    3.8e-16   58.5   0.0    4.6  5  DUF4116        Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.012   14.9   2.3         10    5.4   0.0    4.2  4  DUF3666        Ribose-5-phosphate isomerase
      0.051   13.1   0.1        6.5    6.3   0.0    3.4  4  DNA_gyraseA_C  DNA gyrase C-terminal domain, beta-propeller
      0.053   12.2   0.0      0.077   11.7   0.0    1.3  1  Lgl_C          Lethal giant larvae(Lgl) like, C-terminal
        2.9    7.9   5.6        4.7    7.3   0.0    3.5  4  Pox_A3L        Poxvirus A3L Protein


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.3   6.3e-06     0.023      14      47 ..       9      42 ..       2      45 .. 0.88
   2 !   32.4   0.7   1.5e-11   5.5e-08       1      48 [.      20      69 ..      20      70 .. 0.86
   3 ?   -0.6   0.0      0.31   1.1e+03      21      41 ..      94     114 ..      85     118 .. 0.71
   4 !   58.5   0.0   1.1e-19   3.8e-16       1      49 []     122     170 ..     122     170 .. 0.99
   5 !   21.8   0.0   3.1e-08   0.00011       2      27 ..     173     198 ..     172     201 .. 0.94

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 6.3e-06
     DUF4116 14 salkylseeLknDkeivlkA.vkqngtalsyasee 47
                s+++y+  ++k D +iv+kA  k+n t+l y+  +
  EFC37901.1  9 SSFQYIG-KFKEDEDIVKKAlFKSNFTILHYINSD 42
                6899999.9**********9889999***999766 PP

  == domain 2  score: 32.4 bits;  conditional E-value: 1.5e-11
     DUF4116  1 DrEivleavkkngs.alkyl.seeLknDkeivlkAvkqngtalsyaseeL 48
                D++iv++a+ k ++ +l+y+ s+ L n++e+vl ++k+ng+ ++ ++e +
  EFC37901.1 20 DEDIVKKALFKSNFtILHYInSDFLLNNRELVLTILKSNGKYINEMPEAI 69
                9*******6665555*****66779*******************999865 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.31
     DUF4116  21 eeLknDkeivlkAvkqngtal 41 
                 + + +D+e  + +++ n++ l
  EFC37901.1  94 KIIESDREDFKSILQFNPDLL 114
                 555678887777777777665 PP

  == domain 4  score: 58.5 bits;  conditional E-value: 1.1e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+ +ea++++g++l+++see+k Dke+vl Av +ng+al yas++L+
  EFC37901.1 122 DRELLKEALSHCGFCLRFASEEFKADKELVLTAVTKNGSALMYASPKLK 170
                 9*********************************************997 PP

  == domain 5  score: 21.8 bits;  conditional E-value: 3.1e-08
     DUF4116   2 rEivleavkkngsalkylseeLknDk 27 
                 +Eivl av+++g+a++++s++L+n k
  EFC37901.1 173 EEIVLAAVTNDGKAIRFASKRLSNQK 198
                 8**********************976 PP

>> DUF3666  Ribose-5-phosphate isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.022        80      14      34 ..      20      40 ..      18      42 .. 0.84
   2 ?   -0.8   0.0      0.25     9e+02      28      37 ..      73      82 ..      68      92 .. 0.76
   3 ?    5.4   0.0    0.0028        10      14      24 ..     122     132 ..     111     139 .. 0.85
   4 ?    3.1   0.0     0.015        53      14      23 ..     147     156 ..     145     159 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.022
                -HHHHHHHT-STTHHHHHTTT CS
     DUF3666 14 DqdLvkgAisGerFqeyFFan 34
                D+d+vk A+    F  + + n
  EFC37901.1 20 DEDIVKKALFKSNFTILHYIN 40
                99*******999998777655 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.25
                HHHHTTT--- CS
     DUF3666 28 qeyFFancqd 37
                 e+FF  ++ 
  EFC37901.1 73 RECFFLAART 82
                59***87765 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0028
                 -HHHHHHHT-S CS
     DUF3666  14 DqdLvkgAisG 24 
                 D++L+k+A+s 
  EFC37901.1 122 DRELLKEALSH 132
                 9*******985 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.015
                 -HHHHHHHT- CS
     DUF3666  14 DqdLvkgAis 23 
                 D++Lv +A++
  EFC37901.1 147 DKELVLTAVT 156
                 9*******97 PP

>> DNA_gyraseA_C  DNA gyrase C-terminal domain, beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       0.4   1.4e+03      34      42 ..      16      24 ..      12      25 .. 0.82
   2 ?    1.8   0.0     0.046   1.7e+02       6      21 ..     130     145 ..     129     146 .. 0.88
   3 ?    1.5   0.0     0.058   2.1e+02      30      48 .]     160     182 ..     154     182 .. 0.76
   4 ?    6.3   0.0    0.0018       6.5       5      24 ..     179     198 ..     176     199 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.4
                   ETTTTSSEE CS
  DNA_gyraseA_C 34 klkegdklv 42
                   k+ke++ +v
     EFC37901.1 16 KFKEDEDIV 24
                   89***9998 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.046
                    EETTSEEEEEEGGGS- CS
  DNA_gyraseA_C   6 iTsnGyvkrfplselp 21 
                     ++ G+++rf  +e++
     EFC37901.1 130 LSHCGFCLRFASEEFK 145
                    6999*******99996 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.058
                    EEGS....ETTTTSSEEEEEEES CS
  DNA_gyraseA_C  30 vkgi....klkegdklvsvlvvs 48 
                      ++    klk+ +++v ++v++
     EFC37901.1 160 SALMyaspKLKDCEEIVLAAVTN 182
                    55566777999999999988875 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0018
                    EEETTSEEEEEEGGGS-BT- CS
  DNA_gyraseA_C   5 liTsnGyvkrfplselpeqg 24 
                     +T+ G+++rf    l++q+
     EFC37901.1 179 AVTNDGKAIRFASKRLSNQK 198
                    79*********988888775 PP

>> Lgl_C  Lethal giant larvae(Lgl) like, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   2.2e-05     0.077     265     301 ..     143     178 ..     116     200 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.2e-05
                 EEE-EEEEEEEEEEETTSEEEEEETTT--EEEEEE-S CS
       Lgl_C 265 kteekkkgivlvaltkdgevkvlslPsLkeikkvklp 301
                 +++  +k  vl a+tk+g++ +++ P+Lk+ +++ l 
  EFC37901.1 143 EFK-ADKELVLTAVTKNGSALMYASPKLKDCEEIVLA 178
                 333.68999**********************999886 PP

>> Pox_A3L  Poxvirus A3L Protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.3      0.15   5.5e+02      24      61 ..      18      55 ..      10      60 .. 0.62
   2 ?    7.3   0.0    0.0013       4.7      17      39 ..      90     112 ..      83     121 .. 0.86
   3 ?   -1.5   0.0      0.71   2.5e+03      22      34 ..     118     130 ..     112     134 .. 0.80
   4 ?   -1.4   0.0      0.66   2.4e+03      14      33 ..     171     190 ..     167     200 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.15
     Pox_A3L 24 keDretikmilesqpkk.l.kilkeFLaavrnktllykiL 61
                keD++ +k +l ++    l +i  +FL    n++l + iL
  EFC37901.1 18 KEDEDIVKKALFKSNFTiLhYINSDFL--LNNRELVLTIL 55
                788888877776654321313444566..45677777776 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0013
     Pox_A3L  17 anlveylkeDretikmilesqpk 39 
                 + l++++++Dre  k il+ +p 
  EFC37901.1  90 QSLYKIIESDREDFKSILQFNPD 112
                 6799***************9997 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.71
     Pox_A3L  22 ylkeDretikmil 34 
                 + k+Dre +k +l
  EFC37901.1 118 IFKDDRELLKEAL 130
                 6789999999877 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 0.66
     Pox_A3L  14 kCaanlveylkeDretikmi 33 
                  C + +++ +++D ++i+ +
  EFC37901.1 171 DCEEIVLAAVTNDGKAIRFA 190
                 58888888999999999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.49u 0.24s 00:00:00.73 Elapsed: 00:00:00.42
# Mc/sec: 1453.25
//
Query:       EFC37902.1  [L=191]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.32s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1179.95
//
Query:       EFC37903.1  [L=304]
Description: hypothetical protein NAEGRDRAFT_74410 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.3e-05   23.2   4.8      0.098   12.5   0.5    3.9  3  TPR_1            Tetratricopeptide repeat
     0.0002   21.2   6.9       0.41   10.9   0.0    4.5  5  TPR_2            Tetratricopeptide repeat
    0.00028   20.5   1.3        3.9    7.2   0.1    3.8  3  TPR_11           TPR repeat
     0.0016   18.6   2.6        1.8    8.8   0.0    3.6  3  ANAPC3           Anaphase-promoting complex, cyclosome, subun
     0.0017   18.8   0.1         17    6.0   0.0    3.8  4  TPR_19           Tetratricopeptide repeat
     0.0029   17.8   0.6        2.9    8.3   0.1    3.7  3  TPR_12           Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.022   15.5   0.0        5.9    8.0   0.0    4.2  5  TPR_14           Tetratricopeptide repeat
      0.026   15.0   0.0       0.11   12.9   0.0    2.0  2  Alkyl_sulf_dimr  Alkyl sulfatase dimerisation
      0.039   14.6   0.7         15    6.5   0.0    4.4  5  TPR_6            Tetratricopeptide repeat
      0.047   13.1   0.1       0.17   11.4   0.0    2.1  2  SHNi-TPR         SHNi-TPR
       0.19   11.8   3.1        4.8    7.4   0.0    4.1  5  TPR_7            Tetratricopeptide repeat
       0.45   11.0   6.9       0.44   11.0   0.8    3.6  2  TPR_17           Tetratricopeptide repeat
        7.5    7.0  12.2         18    5.8   0.0    4.8  6  TPR_8            Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.56   7.7e+02      15      34 .]      16      35 ..      11      35 .. 0.84
   2 !    9.2   0.1   0.00081       1.1      15      29 ..      61      75 ..      58      79 .. 0.89
   3 !   12.5   0.5   7.1e-05     0.098       2      25 ..     161     184 ..     160     186 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.56
                T-HHHHHHHHHHHHHHSTTH CS
       TPR_1 15 gkydeAleyyekALelnPnn 34
                g+ ++ ++  +++++ +P+n
  EFC37903.1 16 GDRKQSIDILDECIKTDPKN 35
                56678888899*******97 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00081
                T-HHHHHHHHHHHHH CS
       TPR_1 15 gkydeAleyyekALe 29
                ++y +A+ + ekAL 
  EFC37903.1 61 NNYSDAIHHLEKALA 75
                89***********97 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 7.1e-05
                 HHHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyye 25 
                 + +  +G +y+  g+y+ A+ +y+
  EFC37903.1 161 YLYMSKGGCYYACGMYELAVNAYS 184
                 67999*****************96 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.056        77       7      34 .]       8      35 ..       3      35 .. 0.87
   2 !   10.9   0.0    0.0003      0.41      14      32 ..      60      78 ..      54      80 .. 0.86
   3 !    7.5   0.1    0.0036         5       2      24 ..     161     183 ..     160     186 .. 0.89
   4 ?   -2.8   0.0       6.9   9.5e+03      13      24 ..     211     222 ..     202     232 .. 0.68
   5 ?   -2.3   0.0         5   6.9e+03      15      27 ..     228     240 ..     218     241 .. 0.65

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.056
       TPR_2  7 lGlayyklgdyeeAleafekAleldPnn 34
                   a+y  gd ++ ++ ++++++ dP+n
  EFC37903.1  8 VSAAAYFDGDRKQSIDILDECIKTDPKN 35
                56788889******************97 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.0003
       TPR_2 14 lgdyeeAleafekAleldP 32
                +++y +A++++ekAl++ +
  EFC37903.1 60 RNNYSDAIHHLEKALAYLE 78
                68*************9865 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0036
       TPR_2   2 ealynlGlayyklgdyeeAleaf 24 
                 ++++  G +yy+ g ye A++a+
  EFC37903.1 161 YLYMSKGGCYYACGMYELAVNAY 183
                 67888999*************99 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 6.9
       TPR_2  13 klgdyeeAleaf 24 
                 +lg  +++lea+
  EFC37903.1 211 ALGYSDKCLEAM 222
                 456666666665 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 5
       TPR_2  15 gdyeeAleafekA 27 
                 +  ++A+  f+k 
  EFC37903.1 228 KYNNDARLVFQKI 240
                 3447888888886 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.022        31      17      33 ..      25      41 ..      15      44 .. 0.79
   2 ?    5.2   0.0     0.012        17       7      23 ..      60      76 ..      59      81 .. 0.91
   3 !    7.2   0.1    0.0029       3.9       4      19 ..     170     185 ..     167     190 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.022
      TPR_11 17 YkkAlkldPdnaeayyn 33
                + + +k dP+n  ++y 
  EFC37903.1 25 LDECIKTDPKNIYIHYL 41
                5566999*********6 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.012
      TPR_11  7 qGkyeeAieaYkkAlkl 23
                +++y +Ai +++kAl++
  EFC37903.1 60 RNNYSDAIHHLEKALAY 76
                689************86 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.0029
      TPR_11   4 yyeqGkyeeAieaYkk 19 
                 yy+ G ye A++aY+ 
  EFC37903.1 170 YYACGMYELAVNAYSS 185
                 9*************85 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0    0.0013       1.8      34      69 ..      13      49 ..       6      53 .. 0.88
   2 ?    3.9   0.1     0.045        63       3      41 ..      61     125 ..      59     129 .. 0.59
   3 ?    3.9   0.1     0.047        65      20      47 ..     154     184 ..     142     191 .. 0.63

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0013
                HHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHT CS
      ANAPC3 34 ylngqykrAyellrka.klnskslgcrylfAqcllkL 69
                y +g+ k+ +++l+++ k+++k++ ++yl+A cl  L
  EFC37903.1 13 YFDGDRKQSIDILDECiKTDPKNIYIHYLKASCLNNL 49
                557899999************************9665 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.045
                 T-HHHHHHHHHHHH...........................HHH--HHHHHHHHHHHHHTT-HHH CS
      ANAPC3   3 nnyknAiflaerll..........................aaetespedayllAlclylngqykr 41 
                 nny +Ai ++e++l                          +++ e+ +d+ +   cl+l++ y r
  EFC37903.1  61 NNYSDAIHHLEKALaylenipklplptlaktnfsheieepEKQVERINDLKFTPICLLLANVYAR 125
                 78888888888888666666666555555555555554444555555555555555555555555 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.047
                 H--HHHHHHH...HHHHHHTT-HHHHHHHHH CS
      ANAPC3  20 tespedayll...AlclylngqykrAyellr 47 
                 ++sp+  yl+   + c+y  g y+ A + ++
  EFC37903.1 154 SRSPNEPYLYmskGGCYYACGMYELAVNAYS 184
                 3344444444444788888888777776655 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0     0.012        17       5      35 ..      16      46 ..      12      49 .. 0.85
   2 ?    3.8   0.0     0.062        86       5      22 ..      61      78 ..      58      91 .. 0.82
   3 ?   -2.2   0.0       4.5   6.2e+03      27      37 ..     115     125 ..     111     128 .. 0.74
   4 ?    4.0   0.0     0.051        70      17      48 ..     152     183 ..     145     191 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.012
      TPR_19  5 gdyaeAlalleqalqedpknaearllLAeal 35
                gd  + +++l + ++ dpkn ++ +l A +l
  EFC37903.1 16 GDRKQSIDILDECIKTDPKNIYIHYLKASCL 46
                7778889999999999999999999999887 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.062
      TPR_19  5 gdyaeAlalleqalqedp 22
                ++y +A+ +le+al++  
  EFC37903.1 61 NNYSDAIHHLEKALAYLE 78
                6899********998755 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 4.5
      TPR_19  27 arllLAealla 37 
                 + llLA+++  
  EFC37903.1 115 ICLLLANVYAR 125
                 77899999865 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.051
      TPR_19  17 alqedpknaearllLAeallalgqldeAealL 48 
                 +++ +p+ +++ +    +++a g ++ A ++ 
  EFC37903.1 152 LYSRSPNEPYLYMSKGGCYYACGMYELAVNAY 183
                 57789*********************998765 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.1    0.0021       2.9      14      76 ..      13      78 ..       5      79 .. 0.70
   2 ?    5.0   0.0     0.022        30       8      54 ..     165     210 ..     160     227 .. 0.74
   3 ?   -0.7   0.0       1.3   1.8e+03      21      41 ..     210     230 ..     197     235 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0021
      TPR_12 14 rrlgrydeAlellekaleia.rrllGpdhpltattlrnLgrlyra....lgryeeAlelleealaiae 76
                +  g+  +++++l++++    ++++   h+l a++l+nL    +     +++y +A+ +le+ala +e
  EFC37903.1 13 YFDGDRKQSIDILDECIKTDpKNIYI--HYLKASCLNNLTSSESDlnivRNNYSDAIHHLEKALAYLE 78
                55677777777777777777777765..667888888886666541222469************9876 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.022
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrl 54 
                   + ++++ g y+ A   +  + e+++++l+p+    + ++   g++
  EFC37903.1 165 SKGGCYYACGMYELAVNAYSSV-ERFEAVLDPNAIIDSLCYASNGMV 210
                 5799*************99988.999999999887666666666665 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 1.3
      TPR_12  21 eAlellekaleiarrllGpdh 41 
                  Al + +k+le+++ + ++++
  EFC37903.1 210 VALGYSDKCLEAMEFYIEKYN 230
                 688889999999887765544 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.0    0.0043       5.9      14      42 ..      15      43 ..       5      45 .. 0.86
   2 ?   -0.2   0.0       1.9   2.6e+03      16      29 ..      62      75 ..      59      84 .. 0.75
   3 ?   -2.2   0.0       7.9   1.1e+04       6      16 ..     118     128 ..     117     134 .. 0.76
   4 ?   -0.6   0.0       2.5   3.5e+03      11      27 ..     170     186 ..     162     196 .. 0.79
   5 ?   -0.2   0.0       1.8   2.5e+03      11      40 ..     209     238 ..     202     241 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0043
      TPR_14 14 lGdpdeAiallrralalaPddaeawllla 42
                 Gd +++i++l+++++++P++  +++l a
  EFC37903.1 15 DGDRKQSIDILDECIKTDPKNIYIHYLKA 43
                69999****************99998887 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.9
      TPR_14 16 dpdeAiallrrala 29
                ++ +Ai +l++ala
  EFC37903.1 62 NYSDAIHHLEKALA 75
                67788888888876 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 7.9
      TPR_14   6 alaeallalGd 16 
                 +la +++++ +
  EFC37903.1 118 LLANVYARAAE 128
                 68888888765 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 2.5
      TPR_14  11 llalGdpdeAiallrra 27 
                 ++a G ++ A++++  +
  EFC37903.1 170 YYACGMYELAVNAYSSV 186
                 78999999999999876 PP

  == domain 5  score: -0.2 bits;  conditional E-value: 1.8
      TPR_14  11 llalGdpdeAiallrralalaPddaeawll 40 
                 + alG  d+ +++ + +++++ +da++ ++
  EFC37903.1 209 MVALGYSDKCLEAMEFYIEKYNNDARLVFQ 238
                 678999999999999999999999988765 PP

>> Alkyl_sulf_dimr  Alkyl sulfatase dimerisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   8.2e-05      0.11      78     137 ..      11      71 ..       5      73 .. 0.89
   2 ?   -1.9   0.0       3.1   4.2e+03     108     130 ..     118     140 ..     108     143 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 8.2e-05
                      HHHHTT-HHHHHHHHHHHHHHSTT-HHHHHHHHHHHHHHHHH-SSHH.HHHHHHHHHHHHH CS
  Alkyl_sulf_dimr  78 ealkegdyrwaaellnhlvfadpenaeakelkadaleqlgyqaesat.wRniYlsgakelr 137
                      +a+ +gd + ++ +l+  +  dp+n   + lka++l++l   ++  + +Rn Y  + ++l+
       EFC37903.1  11 AAYFDGDRKQSIDILDECIKTDPKNIYIHYLKASCLNNLTSSESDLNiVRNNYSDAIHHLE 71 
                      5677899999*****************************9998887758*****9999987 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 3.1
                      HHHHHHHHHHHH-SSHHHHHHHH CS
  Alkyl_sulf_dimr 108 lkadaleqlgyqaesatwRniYl 130
                      l+a+++ + ++   s   R+iY 
       EFC37903.1 118 LLANVYARAAESGVSIDLRHIYG 140
                      68999999999999999999995 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0     0.011        15       7      32 ..      10      34 ..       4      35 .. 0.86
   2 ?   -0.4   0.0       1.7   2.4e+03      17      24 ..      71      78 ..      40      82 .. 0.72
   3 ?    1.9   0.0      0.31   4.3e+02       9      26 ..     169     186 ..     163     188 .. 0.87
   4 ?   -1.2   0.0         3   4.1e+03      17      30 ..     216     229 ..     203     231 .. 0.86
   5 ?   -2.4   0.0       7.5     1e+04      19      30 ..     249     260 ..     248     261 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.011
                HHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6  7 alsyrklgdtdkAlealerlikeYPd 32
                a +y+ + d  +++++l+++ik  P+
  EFC37903.1 10 AAAYFDG-DRKQSIDILDECIKTDPK 34
                5577777.***************997 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.7
                HHHHHHHH CS
       TPR_6 17 dkAleale 24
                +kAl++le
  EFC37903.1 71 EKALAYLE 78
                55666665 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.31
                 HHHH.HHHHHHHHHHHHHH CS
       TPR_6   9 syrk.lgdtdkAlealerl 26 
                 +y++ +  ++ A+ a+ ++
  EFC37903.1 169 CYYAcG-MYELAVNAYSSV 186
                 999988.*******99875 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 3
                 HHHHHHHHHHHHH- CS
       TPR_6  17 dkAlealerlikeY 30 
                 dk lea+e  i++Y
  EFC37903.1 216 DKCLEAMEFYIEKY 229
                 78999999999998 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 7.5
                 HHHHHHHHHHH- CS
       TPR_6  19 AlealerlikeY 30 
                 +++ l++++ke+
  EFC37903.1 249 SKDELRQVLKEF 260
                 567899**9997 PP

>> SHNi-TPR  SHNi-TPR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00012      0.17       9      33 ..      55      79 ..      54      81 .. 0.89
   2 ?   -2.7   0.1       3.1   4.2e+03      29      38 .]     252     261 ..     252     261 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00012
    SHNi-TPR  9 EislEnenFpqAveDlrkaLeLreq 33
                ++++ ++n+++A++ l+kaL++ e+
  EFC37903.1 55 DLNIVRNNYSDAIHHLEKALAYLEN 79
                5678899**************9986 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3.1
    SHNi-TPR  29 eLreqllppe 38 
                 eLr+ l+++e
  EFC37903.1 252 ELRQVLKEFE 261
                 79****9986 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.45   6.2e+02       8      32 ..      12      33 ..       9      37 .. 0.75
   2 ?    7.4   0.0    0.0035       4.8      12      34 ..      60      80 ..      45      82 .. 0.77
   3 ?   -1.2   0.1         2   2.8e+03       2      12 ..     116     126 ..     115     129 .. 0.79
   4 ?   -0.5   0.1       1.2   1.6e+03       8      22 ..     169     183 ..     163     191 .. 0.80
   5 ?   -3.2   0.0         9   1.2e+04       8      18 ..     276     286 ..     275     286 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.45
       TPR_7  8 lysrlGdyeeAielyeqsLaltkdp 32
                +y++ Gd+++ i+++ +   +  dp
  EFC37903.1 12 AYFD-GDRKQSIDILDE--CIKTDP 33
                5555.********9999..665555 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0035
       TPR_7 12 lGdyeeAielyeqsLaltkdped 34
                +++y++Ai ++e+  al++ +++
  EFC37903.1 60 RNNYSDAIHHLEK--ALAYLENI 80
                69***********..77765555 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 2
       TPR_7   2 LlnLarlysrl 12 
                 +l La++y r 
  EFC37903.1 116 CLLLANVYARA 126
                 78999999875 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 1.2
       TPR_7   8 lysrlGdyeeAiely 22 
                 +y ++G ye A+  y
  EFC37903.1 169 CYYACGMYELAVNAY 183
                 677889999998776 PP

  == domain 5  score: -3.2 bits;  conditional E-value: 9
       TPR_7   8 lysrlGdyeeA 18 
                 +ysr+++  +A
  EFC37903.1 276 IYSRVNEQTDA 286
                 89999987766 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.8   0.00032      0.44       3      25 ..      26      48 ..      24      79 .. 0.88
   2 ?    1.3   0.1      0.42   5.8e+02       8      32 ..     155     179 ..     152     181 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00032
      TPR_17  3 lkaleldPnnadaynnLAelllk 25
                 ++++ dP+n + ++++A +l +
  EFC37903.1 26 DECIKTDPKNIYIHYLKASCLNN 48
                79******************985 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.42
      TPR_17   8 ldPnnadaynnLAelllknGdlmtA 32 
                 + Pn +++y  ++ +++  G ++ A
  EFC37903.1 155 RSPNEPYLYMSKGGCYYACGMYELA 179
                 67999*************9999987 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0     0.013        18      15      34 .]      16      35 ..       9      35 .. 0.92
   2 ?   -2.3   0.0       5.5   7.6e+03       4      15 ..      39      50 ..      37      54 .. 0.74
   3 ?    0.6   0.0      0.61   8.5e+02      15      28 ..      61      74 ..      60      78 .. 0.81
   4 ?   -1.9   0.0         4   5.5e+03       2      12 ..     114     124 ..     113     126 .. 0.83
   5 ?    5.2   0.3     0.022        30       3      24 ..     162     183 ..     160     187 .. 0.92
   6 ?   -2.9   0.1       8.2   1.1e+04      19      22 ..     220     223 ..     212     228 .. 0.53

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.013
                T-HHHHHHHHHHHHHHHHH. CS
       TPR_8 15 gdyeeAkeyyekaleldpdn 34
                gd ++++  + ++++ dp+n
  EFC37903.1 16 GDRKQSIDILDECIKTDPKN 35
                999***************97 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 5.5
                HHHHHHHHHHTT CS
       TPR_8  4 yynlgsiylklg 15
                +y+++s++ +l 
  EFC37903.1 39 HYLKASCLNNLT 50
                789999988875 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.61
                T-HHHHHHHHHHHH CS
       TPR_8 15 gdyeeAkeyyekal 28
                ++y  A+  +ekal
  EFC37903.1 61 NNYSDAIHHLEKAL 74
                57888999999998 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 4
                 CHHHHHHHHHH CS
       TPR_8   2 eayynlgsiyl 12 
                 +++++l+++y 
  EFC37903.1 114 PICLLLANVYA 124
                 68999**9995 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.022
                 HHHHHHHHHHHTT-HHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyy 24 
                 +y+ +g +y   g ye A+ +y
  EFC37903.1 162 LYMSKGGCYYACGMYELAVNAY 183
                 69999**************999 PP

  == domain 6  score: -2.9 bits;  conditional E-value: 8.2
                 HHHH CS
       TPR_8  19 eAke 22 
                 eA+e
  EFC37903.1 220 EAME 223
                 2333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1028  (0.0573373); expected 358.6 (0.02)
Passed bias filter:                      753  (0.041999); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 1795.51
//
Query:       EFC37904.1  [L=215]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.8e-29  101.1   4.2    5.3e-21   75.8   0.1    2.6  3  DUF778         Protein of unknown function (DUF778)
    0.00011   21.9   0.2    0.00011   21.9   0.2    1.6  2  DUF4796        Domain of unknown function (DUF4796)
     0.0065   16.3   3.2      0.014   15.2   3.2    1.5  1  Peptidase_C97  PPPDE putative peptidase domain
  ------ inclusion threshold ------
      0.028   12.7   0.1      0.029   12.7   0.1    1.2  1  CDC45          CDC45-like protein
      0.035   14.8   0.0      0.055   14.1   0.0    1.3  1  Pex14_N        Peroxisomal membrane anchor protein (Pex14p) c


Domain annotation for each model (and alignments):
>> DUF778  Protein of unknown function (DUF778)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   2.0       3.1   1.1e+04     137     142 ..      37      42 ..       3      62 .. 0.45
   2 !   75.8   0.1   1.5e-24   5.3e-21       1      54 [.      77     130 ..      77     135 .. 0.94
   3 !   33.3   0.9   1.6e-11   5.8e-08     122     189 .]     134     192 ..     127     192 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3.1
      DUF778 137 ssssee 142
                 ++++++
  EFC37904.1  37 EQQQQQ 42 
                 222222 PP

  == domain 2  score: 75.8 bits;  conditional E-value: 1.5e-24
      DUF778   1 iPvvswlfPfiGHvgicnseGvildFagsyyvaveklafGaparywqlkpllme 54 
                 iP+++w++PfiGH+gi+ns+G i+dFag+yy++ +++afG+p+ry+++k+ l +
  EFC37904.1  77 IPLITWILPFIGHMGIANSKGIIHDFAGPYYISIDDFAFGKPTRYLNIKNQLNQ 130
                 8***********************************************997655 PP

  == domain 3  score: 33.3 bits;  conditional E-value: 1.6e-11
      DUF778 122 nsyddadgirsaPdlsssseefqgeeynLltanchsfvalaLnklryedeedwgvvklailvlvkgkw 189
                 ++yd+         ++ss++ f+ + yn++++nch +  ++Ln+l+++ + + +++++ +l++++gk+
  EFC37904.1 134 KNYDQT--------IKSSAKCFRSKMYNFFCQNCHHYTIHCLNQLKFK-NGNISIFEIGFLMFFYGKY 192
                 467777........999*******************************.899**************97 PP

>> DUF4796  Domain of unknown function (DUF4796)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   1.4       2.8     1e+04     116     140 ..      21      48 ..       9      54 .. 0.49
   2 !   21.9   0.2   3.1e-08   0.00011      75     159 ..      89     176 ..      88     186 .. 0.77

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 2.8
     DUF4796 116 qwdevLeqv.sseekwsk..erYeeesh 140
                   d+++++   +++ +++  ++Ye +++
  EFC37904.1  21 DSDDYMNNEhDDDDDYEQqqQQYEHDNN 48 
                 4455555442333334332255655554 PP

  == domain 2  score: 21.9 bits;  conditional E-value: 3.1e-08
     DUF4796  75 HigitdskgkvveydkkGvq.kdeekWeqcv....lvekvseslleqwdevLeqvsseekwskerYeeeshnCydfvLeflkalklaelk 159
                 H+gi++skg + ++        d+    +      + ++ +++ l+++d+++++  s++ +++++Y+   +nC++++++ l++lk+++ +
  EFC37904.1  89 HMGIANSKGIIHDFAGPYYIsIDDFAFGKPTrylnIKNQLNQEQLKNYDQTIKS--SAKCFRSKMYNFFCQNCHHYTIHCLNQLKFKNGN 176
                 99************9765443565555444433344455677777788888876..5788*************************99876 PP

>> Peptidase_C97  PPPDE putative peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   3.2   3.9e-06     0.014      81     123 ..     127     172 ..     111     179 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 3.9e-06
                    ---HHHHHHHHHHHHTT...--GGG-BTTTB-HHHHHHHHHHHHHS CS
  Peptidase_C97  81 evteeevraileelsse...ytgdkYnLiskNCnhFtdelvdfLtg 123
                    ++++e+ +++ + ++s+   ++++ Yn++ +NC h+t + +++L  
     EFC37904.1 127 QLNQEQLKNYDQTIKSSakcFRSKMYNFFCQNCHHYTIHCLNQLKF 172
                    67888999999999996678*****************999998875 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1   8.1e-06     0.029     122     167 ..      10      55 ..       1     159 [. 0.54

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 8.1e-06
       CDC45 122 ayealeeeeesdeede.eeeeeddddeeeeeeeeedeedeeedeees 167
                 ++ + ++++++d++d  + +e+dddd+ e+++++ ++++++++++++
  EFC37904.1  10 EIIQSTHHHNDDSDDYmN-NEHDDDDDYEQQQQQYEHDNNNNNNNNN 55 
                 222222222222222211.1111111111111111111111111111 PP

>> Pex14_N  Peroxisomal membrane anchor protein (Pex14p) conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   1.5e-05     0.055      58     138 ..      17      92 ..       2     103 .. 0.51

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.5e-05
     Pex14_N  58 aassaseqa...qeesasssatpqpqaasqtsqsspspsppaqqqqqqyrpPivtypefltkppkppppPlrtwrdllitatal 138
                 + +++s      ++e+++ +  +q+q+++++ + +++++++ +++++   p i +yp  ++      p Pl+tw   +i  +++
  EFC37904.1  17 HHNDDS--DdymNNEHDDDDDYEQQQQQYEH-D-NNNNNNNNNNNNEIINPSIDRYPYCIVW----TPIPLITWILPFIGHMGI 92 
                 222222..12222222222222323322222.2.2222223333444448999***998883....467999998777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2061  (0.114953); expected 358.6 (0.02)
Passed bias filter:                      708  (0.0394891); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 1293.47
//
Query:       EFC37905.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0015   17.9   0.1     0.0025   17.2   0.1    1.3  1  CorA      CorA-like Mg2+ transporter protein


Domain annotation for each model (and alignments):
>> CorA  CorA-like Mg2+ transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.1   1.4e-07    0.0025     123     187 ..     135     198 ..     123     213 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.4e-07
        CorA 123 lfellekleeeldeledeledstkkeilrelaqlrrrlvklrralapnrevlkrllakaddklld 187
                   e+l+k+ +e+d + d  + + ++++l++ + +rr+++++ ++l++n ev++ l+ k  ++l d
  EFC37905.1 135 ESEILRKIGSEIDLIIDVPFPDHNQKLLQQHYLIRRKAINYDKHLFNNYEVFN-LYVKCMKDLKD 198
                 5799************************************************5.44434444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       486  (0.0271069); expected 358.6 (0.02)
Passed bias filter:                      280  (0.0156172); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1474.76
//
Query:       EFC37906.1  [L=1818]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   1.5e-103  344.8   0.1    4.8e-82  274.6   0.1    3.3  3  CPSase_L_D2      Carbamoyl-phosphate synthase L chain, ATP bi
    6.5e-45  152.1   0.0    2.1e-44  150.4   0.0    2.0  1  CPSase_sm_chain  Carbamoyl-phosphate synthase small chain, CP
    2.1e-41  141.8   0.1    6.8e-41  140.1   0.1    2.0  1  GATase           Glutamine amidotransferase class-I
    5.3e-30  104.3   1.8    3.9e-29  101.5   1.8    2.6  1  CPSase_L_D3      Carbamoyl-phosphate synthetase large chain, 
    5.8e-12   45.5   0.0    7.4e-07   28.9   0.0    2.7  2  ATP-grasp        ATP-grasp domain
    3.6e-10   39.7   0.4    8.9e-06   25.4   0.1    2.5  2  Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
    9.2e-05   22.2   0.0     0.0025   17.5   0.0    2.6  2  ATPgrasp_Ter     ATP-grasp in the biosynthetic pathway with T
  ------ inclusion threshold ------
      0.017   15.2   0.3      0.083   12.9   0.1    2.2  2  ATP-grasp_3      ATP-grasp domain
      0.028   14.1   0.2      0.059   13.0   0.2    1.5  1  CDPS             Cyclodipeptide synthase
      0.032   14.0   0.3       0.18   11.5   0.3    2.4  1  Peptidase_C26    Peptidase C26


Domain annotation for each model (and alignments):
>> CPSase_L_D2  Carbamoyl-phosphate synthase L chain, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  274.6   0.1   2.7e-85   4.8e-82       1     208 [.     752     953 ..     752     956 .. 0.99
   2 !   61.0   0.0   5.9e-20   1.1e-16      24     166 ..    1521    1660 ..    1492    1664 .. 0.88
   3 !    5.2   0.0    0.0073        13     167     202 ..    1705    1740 ..    1691    1746 .. 0.89

  Alignments for each domain:
  == domain 1  score: 274.6 bits;  conditional E-value: 2.7e-85
                  SHHHHHHHHHHTT-BBSSEECSSBSSHHHHHHHHHHH-SSEEEEETTCCTTTTEEEESSHHHHHHHHHHHHHHHHHHHSTS-EEEEE--SSSEEEEEE CS
  CPSase_L_D2   1 DkesakealkkinvpvvpssaapvetleealaiakeigyPviikaafglGGkGmrvarneeelaelvkkalaeakaafgnkqvlvekslkgpkeiEve 98 
                  D++ +++++++i +p+++s+a+  +++eea+ +a++igyPvii+aaf+lGG+G+++a++e el+el+++al+ +      +q+lveks+kg+ke+E+e
   EFC37906.1 752 DRDIFNQKMREISQPIADSKAC--DNVEEAILAASHIGYPVIIRAAFALGGLGSGFANDERELRELATQALSSS------PQILVEKSVKGWKEVEYE 841
                  99********************..*************************************************9......8***************** PP

                  EEEETTS-EEEEEEEEECCEC..TCCCCEEEES-SS--HHHHHHHHHHHHHHHHHHT-EEEEEEEEEEETTTTEEEEEEEESS--CCHHHHHHHHS-- CS
  CPSase_L_D2  99 vlrDakgnvitvcerenslql..rtqkvievAPsqtLtdeerqalreaavkvvrevgvvgagtveflldpkskeyyviEvNtRlsvesalaekaTGld 194
                  v+rD ++n+itvc++en++++  +t+++i+vAPsqtL+++e+++lr+aa+kv+r++g+vg+++++++l+p skey++iEvN+Rls++sala+kaTG++
   EFC37906.1 842 VVRDCNDNCITVCNMENFDPVgiHTGESIVVAPSQTLNNDEYHMLRTAAIKVIRHLGIVGECNIQYALNPYSKEYVIIEVNARLSRSSALASKATGYP 939
                  ************************************************************************************************** PP

                  HHHHHHHHHTT--G CS
  CPSase_L_D2 195 lvkeaakialgekL 208
                  l+++aak++lg++L
   EFC37906.1 940 LAFVAAKLSLGMEL 953
                  ***********998 PP

  == domain 2  score: 61.0 bits;  conditional E-value: 5.9e-20
                   BSSHHHHHHHHHHH-SSEEEEETTCCTTTTEEEESSHHHHHHHHHHHHHHHHHHHSTS-EEEEE--SSSEEEEEEEEEETTS-EEEEEEEEECCEC CS
  CPSase_L_D2   24 vetleealaiakeigyPviikaafglGGkGmrvarneeelaelvkkalaeakaafgnkqvlvekslkgpkeiEvevlrDakgnvitvcerenslql 119 
                     t+e+al +a+++ yPv+i++++ l G  m va++++el + + +a + +k    ++ v + k+ ++ keiE++ ++ + g +i+ +  e +   
   EFC37906.1 1521 LITIEDALIFANKVQYPVLIRPSYVLSGAAMNVAYSDSELLQQLYMAADVSK----EHPVVISKFYENAKEIEIDGVAMN-GEIIIDAISEHVERA 1611
                   5689***********************************************6....9********************965.555555555555555 PP

                   ..TCCCCEEEES-SS--HHHHHHHHHHHHHHHHHHT-EEEEEEEEEEET CS
  CPSase_L_D2  120 ..rtqkvievAPsqtLtdeerqalreaavkvvrevgvvgagtveflldp 166 
                     + ++   + P   L+ +  + +re+a  +v+++ ++g  +++fl+d+
   EFC37906.1 1612 gtHSGDATLICPPYSLSFDIQDLIREKASMIVKSLSISGPFNMQFLFDN 1660
                   68*********************************************97 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0073
                   TTTEEEEEEEESS--CCHHHHHHHHS--HHHHHHHH CS
  CPSase_L_D2  167 kskeyyviEvNtRlsvesalaekaTGldlvkeaaki 202 
                    sk+  viE N R s++ +  +k+  ld ++ a +i
   EFC37906.1 1705 LSKRLRVIECNLRASRSFPFISKTLDLDFIALATRI 1740
                   58999*************************999998 PP

>> CPSase_sm_chain  Carbamoyl-phosphate synthase small chain, CPSase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  150.4   0.0   1.2e-47   2.1e-44       2     128 .]     126     285 ..     125     285 .. 0.89

  Alignments for each domain:
  == domain 1  score: 150.4 bits;  conditional E-value: 1.2e-47
  CPSase_sm_chain   2 avLvLedGtvfeGksfga..............keavGEvvfnTgmtGYqeiltDpsYagqilvltypliGnyGv.......needves...... 68 
                       +L L+dGt ++Gk fga               +++GE+vf+T+m+GY+e+ltDpsY+gqilvlt+pl+GnyG+       +     +      
       EFC37906.1 126 GYLELQDGTRYYGKLFGAnkcliendsnwnspFSVSGECVFTTAMVGYPESLTDPSYHGQILVLTFPLVGNYGApnfkttvS-----Nngnknl 214
                      589**************6589988877766655669**************************************76655441.....1455667 PP

  CPSase_sm_chain  69 ...........ekikvaglvvrelseepsnwraeesLsewlkeekipgisgvDTRaLtkklrekgamkgvi 128
                                 +ki+++gl+v+++s+++s+++a  sL++wl+e++ip+++++DTRa+tkklr++ +m+++i
       EFC37906.1 215 defgllpklesDKIHIRGLIVQDYSHNYSHYEAICSLHRWLQEYNIPALYHIDTRAITKKLRDEKSMLARI 285
                      779999999989*******************************************************9987 PP

>> GATase  Glutamine amidotransferase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  140.1   0.1   3.8e-44   6.8e-41       2     189 ..     336     544 ..     335     545 .. 0.93

  Alignments for each domain:
  == domain 1  score: 140.1 bits;  conditional E-value: 3.8e-44
                 EEESSTSTHHHHHHHHHHTT-EEEEEETTSHHHHH.....................HH.THHSTSEEEEEEESSCTT.TTTHHHHHHHHCT........ CS
      GATase   2 liDnydsvtenlvhalvelgvkvevvpidasaeei.....................le.llknpdgilvsgGpgspg.vegkieaikeare........ 69 
                  iD++  +++n++++lv+++v+++vvp++++ +e                       + +++n+dgi++s+Gpg+p+  +++i++++e+++        
  EFC37906.1 336 AIDCG--MKYNIIRELVKRDVELKVVPYNYNWLELdvnnsnnnntnndnntnnnntNNtNNTNIDGIFISNGPGNPNnFHETISILSEYISlvqqqqqv 432
                 58999..*******************************************999875224699****************888888888888877766555 PP

                 STS-EEEETHHHHHHHHHTTTEEEEEECEEEEEEEEEEEETTTCGGTTTTSEEEEEEEEEEEEESGCHHHTTEEEEEEEETTEEEEEEEEETTTEEEES CS
      GATase  70 nkiPiLGICLGmQllaiefgrkvvkekekehhggtmrlgddetallyglknevierhrHryevnpkelepaglevtakseddeelmeiiekknpfvgvQ 168
                   iPi+GICLG+Ql+++++g++v+k   ++++g+++++ d      + + +++i++++H+y++++ +++p++++ ++ +++d++++++  ++ p++  Q
  EFC37906.1 433 PIIPIFGICLGNQLVGKAIGASVYKLP-FGNRGHNQPVID------QLTRKCFITSQNHGYAIDN-QTLPSNFKPYFINANDQSNEGVYCLNLPIFTAQ 523
                 5699***********************.************......66778*************9.********************************* PP

                 SBTTSTTSTTHHHHHHHHHHH CS
      GATase 169 FHPEststpegpellfnflik 189
                 FHPE++ +p ++ +lf+++i+
  EFC37906.1 524 FHPEAKGGPSDTFFLFDQFID 544
                 ******************997 PP

>> CPSase_L_D3  Carbamoyl-phosphate synthetase large chain, oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.5   1.8   2.2e-32   3.9e-29       2     122 .]    1149    1347 ..    1148    1347 .. 0.83

  Alignments for each domain:
  == domain 1  score: 101.5 bits;  conditional E-value: 2.2e-32
  CPSase_L_D3    2 elkeptdeRifaiaeal.rrglsveeiheltkidpwFLekleelvelekelkkkkk......eldeellreakklGfsDkqiael........... 79  
                   el++ptd+Rifai  a+ + +++v++ih+ t+id+wFL+kl+++++++k+l    k      el+  ll   k++GfsD qia+            
   EFC37906.1 1149 ELTHPTDQRIFAISLAMeHFEMTVDQIHQFTQIDRWFLYKLQNIIQTKKALVGIGKllnslpELPYPLLLLSKQQGFSDLQIASSlpsllyheflq 1244
                   799**************8789******************************99998899999999999***************7657778888888 PP

  CPSase_L_D3   80 ...............................................l............eeeeeeevrelrk.klgilpvykrvDtcAaeFeaet 115 
                                                                               + ++e  vr +rk +++i+p +k++Dt+Aae++a+t
   EFC37906.1 1245 ailknqvqfpyqlscfnnntntnnnsnntttdntnnttnnntnntqpQykdtyknppklsKIDKELMVRFIRKyQYKIEPIVKQIDTLAAEYPAQT 1340
                   88888888888888887777777777777766666666665555555055555666666644567779999976899******************* PP

  CPSase_L_D3  116 pYlYstY 122 
                   +YlY+tY
   EFC37906.1 1341 NYLYTTY 1347
                   ******9 PP

>> ATP-grasp  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   0.0   4.1e-10   7.4e-07       6     139 ..     765     903 ..     760     925 .. 0.87
   2 !   13.7   0.0   1.9e-05     0.034       9     143 ..    1516    1656 ..    1510    1664 .. 0.85

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 4.1e-10
                 --B-EEEEECCHHHHHHHHHHH-SCEEEEESSS-CTTTTEEEECTCCGHHCHHHHC..GTTCEEEEE----SEEEEEEEEEETTC-EEE--EEEEEEET CS
   ATP-grasp   6 lpvprflaveskeeleeaaeelglpvvvKarrlgydGkGqsvvrseedleqaleal..keekvivEefvpfekElsvlvvrsaeGetafypvvetvqed 102
                  p+++  a ++ ee+  aa+++g+pv+++ +  +  G G+ + ++e +l+++++++  ++ +++vE+ v+  kE+   vvr+ + +  ++  +e+    
  EFC37906.1 765 QPIADSKACDNVEEAILAASHIGYPVIIR-AAFALGGLGSGFANDERELRELATQAlsSSPQILVEKSVKGWKEVEYEVVRDCNDNCITVCNMENFDPV 862
                 6788999999*******************.999******************99999889999************************9999999999999 PP

                 TEEE...EEEECEE-SCHHHHHHHHHHH.HHHHHHTSSEEE CS
   ATP-grasp 103 gilr...lsvapaevsekaqkkaeeiak.kiveeLggvGvf 139
                 gi     ++vap++  ++++ +  ++a+ k++++Lg+vG  
  EFC37906.1 863 GIHTgesIVVAPSQTLNNDEYHMLRTAAiKVIRHLGIVGEC 903
                 99743338999999888877666665555*********965 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1.9e-05
                  -EEEEECCHHHHHHHHHHH-SCEEEEESSS-CTTTTEEEECTCCGHHCHHHHC....GTTCEEEEE----SEEEEEEEEEETTC-EEE--EEEEEEE CS
   ATP-grasp    9 prflaveskeeleeaaeelglpvvvKarrlgydGkGqsvvrseedleqaleal....keekvivEefvpfekElsvlvvrsaeGetafypvvetvqe 101 
                  p+++ + + e++  +a+++++pv+++ +    +G    v  s+++l q l ++    ke++v++ +f +  kE+ + +v +++Ge+ + ++ e+v++
  EFC37906.1 1516 PEWANLITIEDALIFANKVQYPVLIR-PSYVLSGAAMNVAYSDSELLQQLYMAadvsKEHPVVISKFYENAKEIEIDGV-AMNGEIIIDAISEHVER 1610
                  7888888888999999*********9.9999999999999888877665555558889****************99998.689***99999999986 PP

                  ....TTEEEEEEECEE-SCHHHHHHHHHHHHHHHHHTSSEEEEEEE CS
   ATP-grasp  102 ....dgilrlsvapaevsekaqkkaeeiakkiveeLggvGvfavEl 143 
                      +g+  l + p+++s ++q  ++e a+ iv++L + G f + +
  EFC37906.1 1611 agthSGDATLICPPYSLSFDIQDLIREKASMIVKSLSISGPFNMQF 1656
                  222256789999******************************9976 PP

>> Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.4   0.1   4.9e-09   8.9e-06      32     174 ..     783     923 ..     751     925 .. 0.83
   2 !   11.8   0.0   7.3e-05      0.13      32     159 ..    1531    1656 ..    1514    1662 .. 0.75

  Alignments for each domain:
  == domain 1  score: 25.4 bits;  conditional E-value: 4.9e-09
                      HHHC-SSEEEEESSSSTTTTEEEESSGGGHHHHHHHHHTT-SCEEEEE--.ESEEEEEEEEETSSCEEEEEEEEE-SSSSS-HHHHHC.TT-EE CS
  Dala_Dala_lig_C  32 eeelgypvfVKpareGSSvGvskveseeelkeaieeafkydekvlvEeai.egreievavlgneklevsevgeivvkkgfydyeakysddkaql 124
                       +++gypv++++a +   +G   ++ e el+e   +a++   ++lvE+ +   +e+e  v+ + + ++ +v ++    + +d    ++++++ +
       EFC37906.1 783 ASHIGYPVIIRAAFALGGLGSGFANDERELRELATQALSSSPQILVEKSVkGWKEVEYEVVRDCNDNCITVCNM----ENFDPVGIHTGESIVV 872
                      4679**********9999********************************6679********666666665544....4466666667788888 PP

                      ESS----HHHHHHHHHHHHHHHHHTT--SEEEEEEEE.ETTTEEEEEEEES CS
  Dala_Dala_lig_C 125 evpaklekeveekiqelalkaykaldlrGlaRvDffl.teegeivlnEvNt 174
                          +l++++++ ++++a+k+ + l++ G + + + l   + e v+ EvN 
       EFC37906.1 873 APSQTLNNDEYHMLRTAAIKVIRHLGIVGECNIQYALnPYSKEYVIIEVNA 923
                      88899********************************667889999***96 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 7.3e-05
                       HHHC-SSEEEEESSSSTTTTEEEESSGGGHHHHHHHH..HTT-SCEEEEE--.ESEEEEE.EEEETSSCEEEEEEEEE-SSSSS-HHHHHC. CS
  Dala_Dala_lig_C   32 eeelgypvfVKpareGSSvGvskveseeelkeaieea..fkydekvlvEeai.egreiev.avlgneklevsevgeivvkkgfydyeakysd 119 
                        ++++ypv+++p+   S   ++ + s +el + +  a  +++++ v++ ++  +++eie+ +v  n++  +  + e+v + g        s+
       EFC37906.1 1531 ANKVQYPVLIRPSYVLSGAAMNVAYSDSELLQQLYMAadVSKEHPVVISKFYeNAKEIEIdGVAMNGEIIIDAISEHVERAGTH------SG 1616
                       57899*********9999999999999999776655511678899*******99*****9778889999999999999877654......34 PP

                       TT-EEESS----HHHHHHHHHHHHHHHHHTT--SEEEEEE CS
  Dala_Dala_lig_C  120 dkaqlevpaklekeveekiqelalkaykaldlrGlaRvDf 159 
                       d++ +  p +l+ ++++ i+e a  + k l+++G   + f
       EFC37906.1 1617 DATLICPPYSLSFDIQDLIREKASMIVKSLSISGPFNMQF 1656
                       4455555566666666666666666666666666555555 PP

>> ATPgrasp_Ter  ATP-grasp in the biosynthetic pathway with Ter operon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   1.4e-06    0.0025      49     120 ..     886     960 ..     874     969 .. 0.78
   2 ?    1.3   0.0      0.14   2.6e+02      15      70 ..    1587    1656 ..    1573    1663 .. 0.63

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.4e-06
  ATPgrasp_Ter  49 lielaerlaeefgldglvnvQvrededg..pkLLEiNpRasGGlg.ysalaGvnlpylalklllgleteeveepe 120
                   l  +a ++++++g+ g  n+Q+  +     ++++E+N+R s      s ++G  l+ +a+kl lg+e  ++++  
    EFC37906.1 886 LRTAAIKVIRHLGIVGECNIQYALNPYSkeYVIIEVNARLSRSSAlASKATGYPLAFVAAKLSLGMELIDIKNSV 960
                   557899***************9987543359*********96555156777**************9777776554 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.14
  ATPgrasp_Ter   15 EySvDvlaekgevl.....aavpRrKe.kgglq........elekdeelielaerlaeefgldglvnvQv 70  
                    E+ +D +a +ge++       v R+ + +g+ +        +++ ++ + e a+ ++++++++g +n+Q+
    EFC37906.1 1587 EIEIDGVAMNGEIIidaisEHVERAGThSGDATlicppyslSFDIQDLIREKASMIVKSLSISGPFNMQF 1656
                    666666666666653221123444444222222556666555556667789999***************8 PP

>> ATP-grasp_3  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.7     3e+03     145     160 ..     662     677 ..     651     706 .. 0.58
   2 ?   12.9   0.1   4.6e-05     0.083      29     159 ..     785     926 ..     758     928 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.7
                  SS.SEEEEEEESS--G CS
  ATP-grasp_3 145 kdeepyviEvNPRltt 160
                  k+e++y i vNP + t
   EFC37906.1 662 KEEGIYTILVNPNIAT 677
                  4445555555554443 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 4.6e-05
                  --SSSEEEEESS-------B--SS--TTE.............EEEE---S.EEEEEEEEE.SSSEEEEEEEEEEEET....TEEEEE...EES----H CS
  ATP-grasp_3  29 eeekklvvKprdGaggesvrvveekeeaeaaieeve......lvqefieG.kplSvsllsdgekvlvlavnrqliekaekefvyaGn...vtpietel 116
                     +++++  + + gg +  ++++++e+ +   +        lv + ++G k++  +++ d +++ + ++n +  +      + +G+   v+p++t +
   EFC37906.1 785 HIGYPVIIRAAFALGGLGSGFANDERELRELATQALssspqiLVEKSVKGwKEVEYEVVRDCNDNCITVCNMENFDPV---GIHTGEsivVAPSQTLN 879
                  448999999999999999999999988875555444678888888889887778888888888888888888888764...44555422145666655 PP

                  ...HHHHHHHHHHHHTTSTT--EEEEEEEEESS...SEEEEEEESS-- CS
  ATP-grasp_3 117 ...keevvelaeevvekleglaGyvGvDlvlkd..eepyviEvNPRlt 159
                      + ++++a +v+++l g++G   +   l+   +e ++iEvN+Rl 
   EFC37906.1 880 ndeYHMLRTAAIKVIRHL-GIVGECNIQYALNPysKEYVIIEVNARLS 926
                  111445678889999999.99999999999998878999*******85 PP

>> CDPS  Cyclodipeptide synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   3.3e-05     0.059      37     132 ..     977    1073 ..     972    1086 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.3e-05
                  HHHHHHHHHHSSEEEEEE--T.THHHHHHHTT--HHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTCEEEEECCCCCC-HHHHHHHHHHHHHHHH-HH CS
        CDPS   37 aalirwaareFaqvdvvvadt.evaellealGyspeeArrkaarelravrarieraleeagpepervrvrrlseflanpaYrelraeveralaedee 132 
                   ++ rw  ++F++v+ v+ +  +     +a G + eeA +ka+r +++  +  ++a ++ + e+   +    s+ +an++  ++ ++ ++ ++++ +
  EFC37906.1  977 VKMPRWDLKKFTRVSTVIGSAmKSVGEVMAIGRNFEEAIQKAIRMVDTSYRGFDSANSSFDLEKLMKQYSSSSNTAANTNTTTASSNHHQHHHQQYQ 1073
                  56779************999989999**********************************9888877899999999999888888888888877765 PP

>> Peptidase_C26  Peptidase C26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.3    0.0001      0.18     105     128 ..     434     457 ..     385     527 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.0001
  Peptidase_C26 105 gvPilgiCrGlqllnvalGGtlyq 128
                     +Pi+giC+G ql+  a+G ++y+
     EFC37906.1 434 IIPIFGICLGNQLVGKAIGASVYK 457
                    48*****************99885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1818 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1549  (0.0863963); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.20u 0.37s 00:00:01.56 Elapsed: 00:00:00.55
# Mc/sec: 10025.32
//
Query:       EFC37907.1  [L=1253]
Description: kinesin-7 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.4e-89  298.2   4.8    6.4e-89  298.2   4.8    2.9  3  Kinesin         Kinesin motor domain
    1.9e-22   79.8   0.2    1.9e-22   79.8   0.2    3.6  2  Microtub_bd     Microtubule binding
  ------ inclusion threshold ------
        0.1   12.6   0.4       0.57   10.2   0.1    2.4  2  U62_UL91        Functional domain of U62 and UL91 proteins
        4.9    7.1   7.0         11    6.0   1.1    3.1  3  WD40_alt        Alternative WD40 repeat motif


Domain annotation for each model (and alignments):
>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  298.2   4.8   1.4e-92   6.4e-89      33     333 .]      18     322 ..       7     322 .. 0.93
   2 ?   -7.3   6.9         4   1.8e+04     154     154 ..     448     448 ..     357     527 .. 0.54
   3 ?   -5.9   7.0         4   1.8e+04      31      71 ..     510     550 ..     473     587 .. 0.53

  Alignments for each domain:
  == domain 1  score: 298.2 bits;  conditional E-value: 1.4e-92
                 EEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHTTSEEEEEEEESTTSSHHHHHTBCTTTSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEE CS
     Kinesin  33 kenkeeeekkfkFdkvfdeeatqeevyeetakplvesvleGynatifaYGqtgsGKTyTmegkeeeeeGiipraleelFesikkekeekekefsvkvsy 131
                 k+++ + +k+ +Fd vfde ++++++y+++ +++v sv eGyn+t faYGqt sGKT+Tm+g+ ++++G+i  a++++F++ik+++ e + +f ++vsy
  EFC37907.1  18 KNQDPTLTKSMNFDFVFDELSNTKDIYDKLLSEMVPSVCEGYNVTTFAYGQTASGKTFTMKGT-NDKPGLIRLAIRDVFDQIKNSEGE-NRTFLIRVSY 114
                 44555668999***************************************************9.999***************998877.999******* PP

                 EEEETTEEEETTSTTTTSTSSEBEEEECTTSCCEEETTS--EEESSHHHHHHHHHHHHHHHTSTTSSCTSHHCCSEEEEEEEEEEEETTTTTC.EE... CS
     Kinesin 132 lEiYneeiyDLLeskkskkkkklkiredskkgevyvkgltevevksaeevlellekgeknrkvaetklneeSSRSHavftitleqknlkeete.ek... 226
                 lEiYne+++DLL+++    ++ ++i  d++k+ +  + lte+ v+s +e ++++++g ++  va+t +n++SSRSH++f++ +e+k++ + ++ ++   
  EFC37907.1 115 LEIYNEKVRDLLSPE----QRYVNIFVDKNKN-LSFDHLTEEIVRSEQETMDIISRGTSHIMVAKTVANDASSRSHTIFRMIVERKDELAVDNaQQlqs 208
                 *************99....45699******75.****************************************************99877766433778 PP

                 ...........EEEEEEEEEEEEECCCHHHHSSTCHHHHHHHHHHHHHHHHHHHHHHHHHHTCCTSTSCGGGSHHHHHTGGGHSSSSEEEEEEEE-TBG CS
     Kinesin 227 ...........vkisklnLvDLAGsErasktgaaegerlkEaaniNkSLlaLgrvisaLaekkkskhipYRdSkLTrlLqdsLgGnsktlmivtvspss 314
                            v+i++lnLvDLAGsE+ s++   + +r +E++niN SLl L+++i++L++   +k+  +R+SkLTr+L dsLgGn+++++++ +sp+ 
  EFC37907.1 209 slakkakskqiVRIGNLNLVDLAGSENSSEQA--DYNRKREGQNINLSLLHLKEIITKLSNG--EKVTSFRNSKLTRILGDSLGGNARVAVVCAISPDP 303
                 9999**********************987777..56789***********************..*********************************** PP

                 GGHHHHHHHHHHHHHHCTT CS
     Kinesin 315 enleetlstlkfaerakei 333
                  +l+et +tl+f++ a++i
  EFC37907.1 304 VKLKETKRTLEFGSNAQKI 322
                 ****************987 PP

  == domain 2  score: -7.3 bits;  conditional E-value: 4
                 B CS
     Kinesin 154 l 154
                 l
  EFC37907.1 448 L 448
                 2 PP

  == domain 3  score: -5.9 bits;  conditional E-value: 4
                 EEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHH CS
     Kinesin  31 skkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvl 71 
                   ++++++ e+  + ++ f++e ++e++ +e a++++++ +
  EFC37907.1 510 MISDQNKQIESFKQVNEHFEREYQKEKMAKEEASKVIQQKM 550
                 22222222222222333344444444444444444444433 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.8   0.2   4.3e-26   1.9e-22      37     149 .]      13     126 ..       2     126 .. 0.91
   2 ?   -1.1   6.3      0.35   1.6e+03       3      57 ..     499     559 ..     497     610 .. 0.66

  Alignments for each domain:
  == domain 1  score: 79.8 bits;  conditional E-value: 4.3e-26
                  EEEETTT...TTTEEEE-SEEEECTTHCCCCCCC.CHHHHHHHHTT--EEEEEEES................ST-HCHHHHHHHHHHCCTSCCCCEEE CS
  Microtub_bd  37 akikfpeeekkkkkefsFdrvfeseseqeevfee.isqlvqsaldgynvcifaygqTGsGKtyTmegeeeeagmipraveeifetiselkekgwkyei 133
                   +i+ ++++ + +k+ +Fd vf++ s+++++++  +s +v s+ +gynv+ faygqT sGKt+Tm+g+++++g i  a++ +f++i++ + ++ ++ i
   EFC37907.1  13 NSIELKNQDPTLTKSMNFDFVFDELSNTKDIYDKlLSEMVPSVCEGYNVTTFAYGQTASGKTFTMKGTNDKPGLIRLAIRDVFDQIKNSEGENRTFLI 110
                  4566666777889999**************99983589999999****************************************************** PP

                  EEEEEEEESS-EEETT CS
  Microtub_bd 134 elqfveiynekvqDlL 149
                  +++++eiynekv+DlL
   EFC37907.1 111 RVSYLEIYNEKVRDLL 126
                  ***************8 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.35
                  HHHHHHHHCHHHHHHHCTB-EEEEEEECCCS-T.EEEETTT..........TTTEEEE-SEE CS
  Microtub_bd   3 keetlRrkleNtiqelkGniRvfarvrpelesekakikfpe.......eekkkkkefsFdrv 57 
                  +ee++Rr+ e  i +++ +i  f +v+++ e+e  k k+++       + +k ++  + ++ 
   EFC37907.1 499 NEESSRRRAEEMISDQNKQIESFKQVNEHFEREYQKEKMAKeeaskviQ-QKMEEMQNMQQQ 559
                  689999999*****************99999975333333223444531.222222222222 PP

>> U62_UL91  Functional domain of U62 and UL91 proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.3   5.7e+03      53      61 ..     145     153 ..     141     154 .. 0.88
   2 ?   10.2   0.1   0.00013      0.57       7      39 ..     623     655 ..     614     660 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.3
    U62_UL91  53 FdnLavEiv 61 
                 Fd+L+ Eiv
  EFC37907.1 145 FDHLTEEIV 153
                 9******98 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00013
    U62_UL91   7 elkddfeacetkeDlFkiiDklsknfnFlveqv 39 
                 e+k++ e+c+t++ l  ++D l k++    +q 
  EFC37907.1 623 EIKKLQENCKTQDYLQHFVDTLEKDMKSYKQQL 655
                 8*********************99987666665 PP

>> WD40_alt  Alternative WD40 repeat motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       2.3     1e+04       7      24 ..      99     116 ..      99     122 .. 0.87
   2 ?    6.0   1.1    0.0024        11      10      37 ..     358     385 ..     352     388 .. 0.87
   3 ?    3.2   0.2     0.018        80      14      31 ..     677     694 ..     662     695 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 2.3
    WD40_alt   7 KnvlGdqeqlkvrvseLe 24 
                 Kn  G+     +rvs Le
  EFC37907.1  99 KNSEGENRTFLIRVSYLE 116
                 788888888999***998 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0024
    WD40_alt  10 lGdqeqlkvrvseLeeEVrtLrKInkdL 37 
                 l +q +++v   e eeEV+ L +I  dL
  EFC37907.1 358 LTNQSNTQVEKEETEEEVKELERIMSDL 385
                 567999******************9998 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.018
    WD40_alt  14 eqlkvrvseLeeEVrtLr 31 
                  +lk +v+ Le+E+++L+
  EFC37907.1 677 IELKKKVTSLENELEALK 694
                 46999**********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3940  (0.219756); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                       189  (0.0105416); expected 17.9 (0.001)
Passed Fwd filter:                        60  (0.00334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 2.26u 0.47s 00:00:02.72 Elapsed: 00:00:00.70
# Mc/sec: 5372.40
//
Query:       EFC37908.1  [L=624]
Description: hypothetical protein NAEGRDRAFT_59637 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.5e-32  111.1  23.4     0.0059   17.4   0.1   11.7 13  WD40         WD domain, G-beta repeat
    2.2e-17   63.1   0.2      0.024   15.0   0.0    7.7  8  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    0.00021   20.7   5.5       0.83    8.9   0.1    4.1  4  WD40_like    WD40-like domain
  ------ inclusion threshold ------
      0.039   12.9   0.1        6.9    5.5   0.0    3.4  3  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
      0.041   14.4   0.8         24    5.6   0.0    5.0  6  PQQ_3        PQQ-like domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         5   1.8e+04      12      25 ..      19      33 ..      11      34 .. 0.68
   2 !   16.4   0.0   3.5e-06     0.012       7      38 .]      55      92 ..      47      92 .. 0.81
   3 !   15.2   0.0   8.1e-06     0.029       3      37 ..      98     135 ..      96     135 .. 0.79
   4 ?   -1.8   0.0         2   7.2e+03      14      36 ..     153     175 ..     144     176 .. 0.68
   5 !   11.1   0.0   0.00017      0.59      12      34 ..     243     265 ..     230     267 .. 0.87
   6 ?   -1.3   0.1       1.3   4.8e+03      12      34 ..     284     305 ..     277     306 .. 0.77
   7 ?    4.1   0.0     0.027        97       8      38 .]     322     353 ..     313     353 .. 0.73
   8 !    9.9   0.0   0.00039       1.4      14      35 ..     371     392 ..     365     394 .. 0.94
   9 !   17.4   0.1   1.6e-06    0.0059      12      37 ..     423     448 ..     406     449 .. 0.83
  10 !   14.1   0.2   1.9e-05     0.066       5      38 .]     459     493 ..     455     493 .. 0.85
  11 ?    5.3   0.0     0.011        40      19      38 .]     516     534 ..     509     534 .. 0.77
  12 !    9.6   0.0   0.00048       1.7      14      37 ..     553     576 ..     540     577 .. 0.88
  13 !   13.0   0.0     4e-05      0.14       8      37 ..     588     618 ..     581     619 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 5
                SE.EEEEEETTSSEE CS
        WD40 12 sv.tslafspdgawl 25
                 v t+l  +p+++ +
  EFC37908.1 19 TVnTGLHLHPNQKHI 33
                287888889988765 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 3.5e-06
                EESS.SSEEEEEEETTSSEEEEE...ET..TSEEEEEE CS
        WD40  7 ltGH.ssvtslafspdgawlasG...sd..DgtvriWd 38
                l+GH +++++la s+ g+++a+G   ++  +  + iWd
  EFC37908.1 55 LSGHnGPISCLAISKTGRFIATGqttHMgfKADIIIWD 92
                79**777***************8754224499999998 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 8.1e-06
                 EEEEEESS.SSEEEEEEETTSSEEEE.EE.TTSEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlas.Gs.dDgtvriW 37 
                 +l+ l  H   v +l+fs d ++l+s G+ dD+++ +W
  EFC37908.1  98 LLHRLNLHhAKVECLSFSEDEQLLVSvGGrDDNNITVW 135
                 56667656466************99645458*****99 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 2
                 EEEE.EETTSSEEEEEETTSEEEE CS
        WD40  14 tsla.fspdgawlasGsdDgtvri 36 
                 t+++ f+ d + ++ ++ ++ +++
  EFC37908.1 153 TCVQfFHNDRSTFMVAG-KQMCKV 175
                 78886666666666667.777776 PP

  == domain 5  score: 11.1 bits;  conditional E-value: 0.00017
                 SEEEEEEETTSSEEEEEETTSEE CS
        WD40  12 svtslafspdgawlasGsdDgtv 34 
                 +v sl+fsp+g+ ++ G+ Dg+v
  EFC37908.1 243 GVESLCFSPSGKSIFIGGGDGSV 265
                 499**********998877**98 PP

  == domain 6  score: -1.3 bits;  conditional E-value: 1.3
                 SEEEEEEETTSSEEEEEETTSEE CS
        WD40  12 svtslafspdgawlasGsdDgtv 34 
                 +vts++   + + l++G+ +++v
  EFC37908.1 284 GVTSICARESDNILICGT-NQSV 305
                 489999888888888887.7665 PP

  == domain 7  score: 4.1 bits;  conditional E-value: 0.027
                 ESSSS.EEEEEEETTSSEE.EEEETTSEEEEEE CS
        WD40   8 tGHss.vtslafspdgawl.asGsdDgtvriWd 38 
                 t Hs+ +++++++++ + + a++s  + +r+W+
  EFC37908.1 322 TCHSHrINDVCYPREASEIiATCS-INDIRVWN 353
                 466556****98888888626888.88889987 PP

  == domain 8  score: 9.9 bits;  conditional E-value: 0.00039
                 EEEEEETTSSEEEEE.ETTSEEE CS
        WD40  14 tslafspdgawlasG.sdDgtvr 35 
                 +++ fsp g+ ++sG s Dg++r
  EFC37908.1 371 NCITFSPTGNAIISGwS-DGKIR 392
                 8****************.****8 PP

  == domain 9  score: 17.4 bits;  conditional E-value: 1.6e-06
                 SEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  12 svtslafspdgawlasGsdDgtvriW 37 
                 +vt++  s+d+  ++sG+ Dg vr+W
  EFC37908.1 423 GVTAITMSSDSERIVSGGSDGQVRVW 448
                 49***************88******* PP

  == domain 10  score: 14.1 bits;  conditional E-value: 1.9e-05
                 EEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                  +   H   v+s+   +d++  +++sdDgt+ +W+
  EFC37908.1 459 ASMNEHkATVNSIHIRRDNSECVTSSDDGTCIVWN 493
                 566789555*****9999999999**********8 PP

  == domain 11  score: 5.3 bits;  conditional E-value: 0.011
                 ETTSSEEEEEETTSEEEEEE CS
        WD40  19 spdgawlasGsdDgtvriWd 38 
                 ++++++l++Gs D+ v  Wd
  EFC37908.1 516 NDESQLLTCGS-DKQVTYWD 534
                 55667787888.*****998 PP

  == domain 12  score: 9.6 bits;  conditional E-value: 0.00048
                 EEEEEETTSSEEEEEETTSEEEEE CS
        WD40  14 tslafspdgawlasGsdDgtvriW 37 
                 ++l+ + dg++++sG++ + v +W
  EFC37908.1 553 NALDIDYDGQYFVSGGKQKVVNVW 576
                 78999******************* PP

  == domain 13  score: 13.0 bits;  conditional E-value: 4e-05
                 ESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtvriW 37 
                  GH +++t  +fsp g++++s ++ g v iW
  EFC37908.1 588 LGHaGNITKAKFSPCGRFICSVGEEGGVFIW 618
                 49*878*************98899******* PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0   0.00067       2.4      37      91 ..      58     116 ..      53     117 .. 0.84
   2 !   10.3   0.0   0.00019      0.67      37      88 ..     105     156 ..      90     160 .. 0.81
   3 !   12.4   0.0     4e-05      0.14      12      66 ..     213     269 ..     210     315 .. 0.90
   4 !   15.0   0.0   6.6e-06     0.024      19      77 ..     341     406 ..     329     419 .. 0.84
   5 !    6.6   0.3    0.0026       9.2      40      88 ..     423     472 ..     406     495 .. 0.71
   6 ?    1.8   0.0     0.081   2.9e+02      42      83 ..     510     551 ..     507     560 .. 0.85
   7 ?    4.7   0.0      0.01        36      34      76 ..     545     587 ..     518     600 .. 0.83
   8 ?    3.0   0.0     0.036   1.3e+02      34      64 ..     587     617 ..     570     619 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00067
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavays.....dgevrlldaesgkvvhslsvksekavtclgWge 91 
                  +++ +++La ++ g+++a +       +  + + d e+ +++h l+ ++  +v cl+++e
   EFC37908.1  58 HNGPISCLAISKTGRFIATGQTthmgfKADIIIWDFEERRLLHRLNLHHA-KVECLSFSE 116
                  6788999***********99872222245899****************99.5****9986 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00019
  ANAPC4_WD40  37 edsevrsLaWkpdgklLav..aysdgevrlldaesgkvvhslsvksekavtclg 88 
                  +  +v++L++++d++lL+   + +d+++ +  +++gk v   ++++    tc++
   EFC37908.1 105 HHAKVECLSFSEDEQLLVSvgGRDDNNITVWYVQTGKPVCGTTTTAL--GTCVQ 156
                  5789*************97335789************9998887766..46665 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 4e-05
  ANAPC4_WD40  12 latedgellvfRlngqrvwtl..eedkedsevrsLaWkpdgklLavaysdgevrlld 66 
                  +++++g++++  l+g + +++  +++k  + v+sL+++p+gk + ++  dg+v ++ 
   EFC37908.1 213 MGSTTGDIICVQLKGPKNFKFmgPKEKIVQGVESLCFSPSGKSIFIGGGDGSVTVVA 269
                  5678999999999999999997777788899**********************9875 PP

  == domain 4  score: 15.0 bits;  conditional E-value: 6.6e-06
  ANAPC4_WD40  19 llvfRlngqrvwtl.......eedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhsls 77 
                  ++ + +n  rvw++         + ++ e +++ ++p g+ +  ++sdg++r +  +sgk++  ++
   EFC37908.1 341 IATCSINDIRVWNVlkskellRIQVPNLECNCITFSPTGNAIISGWSDGKIRAFGPQSGKLLYVIN 406
                  5556677888999988777776688899999*****************************998775 PP

  == domain 5  score: 6.6 bits;  conditional E-value: 0.0026
  ANAPC4_WD40  40 evrsLaWkpdgklLavaysdgevrlldaesg..kvvhslsvksekavtclg 88 
                   v+++  + d + ++ + sdg+vr+ ++ +   ++v s++ ++  +v++++
   EFC37908.1 423 GVTAITMSSDSERIVSGGSDGQVRVWQVAKSsqTLVASMNEHKA-TVNSIH 472
                  588999999999************99986541034444444443.465554 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.081
  ANAPC4_WD40  42 rsLaWkpdgklLavaysdgevrlldaesgkvvhslsvkseka 83 
                  r++++ +d++ L    sd +v   da++ + +++l+ ++e++
   EFC37908.1 510 RQICYLNDESQLLTCGSDKQVTYWDAYDCTAIRELREAEEDE 551
                  6899999*********************99999988777655 PP

  == domain 7  score: 4.7 bits;  conditional E-value: 0.01
  ANAPC4_WD40  34 edkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhsl 76 
                  +++e+ e ++L    dg+ ++ + ++  v++ +  +g++v++ 
   EFC37908.1 545 REAEEDEMNALDIDYDGQYFVSGGKQKVVNVWHYDNGEIVQQG 587
                  677889999*******************************985 PP

  == domain 8  score: 3.0 bits;  conditional E-value: 0.036
  ANAPC4_WD40  34 edkedsevrsLaWkpdgklLavaysdgevrl 64 
                    ++ +++++ +++p g++++ + ++g v +
   EFC37908.1 587 GLGHAGNITKAKFSPCGRFICSVGEEGGVFI 617
                  3577899***************999998765 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1       0.2   7.3e+02      14      45 ..     121     155 ..     107     221 .. 0.73
   2 !    8.9   0.1   0.00023      0.83      55     163 ..     255     370 ..     242     391 .. 0.73
   3 !    4.6   0.1    0.0046        17       5      72 ..     426     494 ..     423     525 .. 0.78
   4 !    6.8   0.0    0.0011       3.8       2      36 ..     551     585 ..     550     599 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.2
   WD40_like  14 lilyGgkdd.kctvlkleslesv..sivesfedSv 45 
                 l+++Gg+dd ++tv  +++++ v  +  + +   v
  EFC37908.1 121 LVSVGGRDDnNITVWYVQTGKPVcgTTTTALGTCV 155
                 56788876625788888888777223334444444 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00023
   WD40_like  55 lilvvtlDGtillsllenee..evenekieedistvkvi..ddklliGtnkGsiyvfsk..dlqleevllgqsseIkeikie...nnkiysLsesafiv 144
                  i ++  DG +  +++ ++   +++++ +   ++ ++    d+ l+ Gtn+  iy  +    l+   +   +s  I+++++    +++i + s +   v
  EFC37908.1 255 SIFIGGGDGSV--TVVAKDTllKISSTILMGGVTSICAResDNILICGTNQSVIYAMKGsgKLEATLIATCHSHRINDVCYPreaSEIIATCSINDIRV 351
                 56777778888..77777777788888888888877654114555669999999997651156666667778899999998633366788888888888 PP

   WD40_like 145 fdlfsqnieykisvkdikt 163
                 +++   + + +i+v + ++
  EFC37908.1 352 WNVLKSKELLRIQVPNLEC 370
                 8888888888888877766 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.0046
   WD40_like   5 sidiskkgslilyGgkddkctvlkle..slesvsivesfedSvifvkllddd.lilvvtlDGtillsllen 72 
                 +i +s +++ i+ Gg d +++v ++   s+++v ++++ +  v  + +  d+   +  + DGt    + ++
  EFC37908.1 426 AITMSSDSERIVSGGSDGQVRVWQVAksSQTLVASMNEHKATVNSIHIRRDNsECVTSSDDGTC--IVWNL 494
                 78999*****************998622667788888888888777777666356666778887..44444 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0011
   WD40_like   2 eiYsidiskkgslilyGgkddkctvlkleslesvs 36 
                 e+ ++di+ +g++++ Ggk++ + v + +++e+v+
  EFC37908.1 551 EMNALDIDYDGQYFVSGGKQKVVNVWHYDNGEIVQ 585
                 67799*************************99885 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.23   8.4e+02      26     246 ..      66     117 ..      55     142 .. 0.46
   2 ?    1.3   0.0     0.037   1.3e+02     179     214 ..     358     394 ..     337     397 .. 0.79
   3 ?    5.5   0.0    0.0019       6.9     189     221 ..     423     455 ..     402     468 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.23
    Ge1_WD40  26 avhregkylayaikvkntgeglvrvvnketeeraLlkglkgevldlafahvsskillavdekgslfvykveeveskllvslllkveapietvvsesdrv 124
                 a++++g+++a +  ++   +    ++  + eer Ll+                                                              
  EFC37908.1  66 AISKTGRFIATGQTTHM--GFKADIIIWDFEERRLLH-------------------------------------------------------------- 100
                 44444444444443333..222334444445555555.............................................................. PP

    Ge1_WD40 125 iWCPyipeedaeesdddeaskllvltrgdkaeiwsvdmiaskygsgelsveeieegllkieehsliveaafspdGtalatasedGevkffqvyledeee 223
                                                                                                                    
  EFC37908.1   - ---------------------------------------------------------------------------------------------------   -
                 ................................................................................................... PP

    Ge1_WD40 224 prCLheWkPhdGkslssllfldn 246
                      +   h  k + +l f ++
  EFC37908.1 101 -----RLNLHHAK-VECLSFSED 117
                 .....44444433.333333332 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.037
    Ge1_WD40 179 egllkieehs.liveaafspdGtalatasedGevkff 214
                 + ll+i+    +  + +fsp G a+    +dG+++ f
  EFC37908.1 358 KELLRIQVPNlECNCITFSPTGNAIISGWSDGKIRAF 394
                 45677776665778899*****************977 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0019
    Ge1_WD40 189 liveaafspdGtalatasedGevkffqvylede 221
                  ++  ++s+d   +    +dG+v+ +qv  + +
  EFC37908.1 423 GVTAITMSSDSERIVSGGSDGQVRVWQVAKSSQ 455
                 4777899*********************87766 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.2       3.2   1.1e+04       4      19 ..     134     149 ..     133     153 .. 0.72
   2 ?    0.4   0.0      0.28     1e+03      21      36 ..     208     223 ..     193     226 .. 0.75
   3 ?    5.6   0.0    0.0068        24      20      40 .]     252     272 ..     243     272 .. 0.86
   4 ?   -1.6   0.0       1.2   4.2e+03      20      35 ..     293     308 ..     283     309 .. 0.87
   5 ?    1.1   0.0      0.17   6.3e+02      22      40 .]     379     398 ..     375     398 .. 0.80
   6 ?   -2.1   0.0       1.7     6e+03      22      39 ..     501     518 ..     498     519 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.2
       PQQ_3   4 lWsvqlpgpvnsspav 19 
                 +W vq++ pv +++++
  EFC37908.1 134 VWYVQTGKPVCGTTTT 149
                 5888999999766654 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.28
       PQQ_3  21 gglvyvgtgdGtlyAl 36 
                 + + y+g++ G + ++
  EFC37908.1 208 DSYAYMGSTTGDIICV 223
                 4699*******99997 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0068
       PQQ_3  20 dgglvyvgtgdGtlyAlDaet 40 
                 +g  +++g+gdG+++ +  +t
  EFC37908.1 252 SGKSIFIGGGDGSVTVVAKDT 272
                 57789*********9987665 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 1.2
       PQQ_3  20 dgglvyvgtgdGtlyA 35 
                 +++++ +gt +  +yA
  EFC37908.1 293 SDNILICGTNQSVIYA 308
                 68999****9999998 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.17
       PQQ_3  22 glvyvgtg.dGtlyAlDaet 40 
                 g   ++++ dG+++A+ +++
  EFC37908.1 379 GNAIISGWsDGKIRAFGPQS 398
                 556677779*******9875 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 1.7
       PQQ_3  22 glvyvgtgdGtlyAlDae 39 
                 +++y+ t+   ++ l+ e
  EFC37908.1 501 NIIYAPTYFRQICYLNDE 518
                 579*****9999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (624 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       519  (0.0289475); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3774.39
//
Query:       EFC37909.1  [L=1083]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     2e-140  456.4  89.8    1.5e-15   56.7   0.1   21.6 23  DUF4116   Domain of unknown function (DUF4116)
     0.0012   18.6   0.5       0.18   11.6   0.0    4.7  6  DUF5615   Domain of unknown function (DUF5615)
  ------ inclusion threshold ------
       0.34   10.8   3.0         56    3.7   0.1    4.6  5  ROQ_II    Roquin II domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.1   6.8e-10   4.1e-06       4      49 .]      91     136 ..      89     136 .. 0.95
   2 !   18.9   0.0   1.6e-07   0.00094       1      41 [.     113     153 ..     113     157 .. 0.92
   3 !   29.8   0.5   6.1e-11   3.6e-07       1      48 [.     171     218 ..     171     219 .. 0.97
   4 !   40.0   2.3   3.8e-14   2.3e-10       1      49 []     220     271 ..     220     271 .. 0.91
   5 !   40.2   0.5   3.3e-14     2e-10       1      38 [.     249     285 ..     249     288 .. 0.96
   6 !   53.0   0.3   3.4e-18     2e-14       1      49 []     273     322 ..     273     322 .. 0.98
   7 !   32.6   0.3     8e-12   4.8e-08       1      44 [.     324     367 ..     324     368 .. 0.97
   8 ?    0.7   0.0     0.072   4.3e+02      16      35 ..     364     386 ..     355     421 .. 0.79
   9 !   30.4   0.0     4e-11   2.4e-07       1      49 []     433     485 ..     433     485 .. 0.95
  10 !   56.7   0.1   2.4e-19   1.5e-15       1      49 []     462     510 ..     462     510 .. 0.99
  11 !   41.8   0.7   1.1e-14   6.7e-11       1      47 [.     487     533 ..     487     536 .. 0.96
  12 !   23.4   0.2   6.1e-09   3.6e-05       1      48 [.     512     561 ..     512     562 .. 0.92
  13 !    8.0   0.0   0.00038       2.3       1      36 [.     538     574 ..     538     583 .. 0.84
  14 !   26.8   0.1   5.2e-10   3.1e-06       1      38 [.     588     625 ..     588     634 .. 0.92
  15 !   15.2   0.0   2.2e-06     0.013       1      34 [.     640     673 ..     640     678 .. 0.91
  16 !   33.7   1.3   3.6e-12   2.1e-08       1      49 []     665     715 ..     665     715 .. 0.96
  17 !   50.3   0.4   2.3e-17   1.4e-13       1      49 []     717     765 ..     717     765 .. 0.98
  18 !   14.5   1.2   3.7e-06     0.022       2      42 ..     796     835 ..     795     842 .. 0.83
  19 !   21.0   0.1   3.3e-08    0.0002      14      49 .]     854     889 ..     843     889 .. 0.88
  20 !   30.7   0.1   3.2e-11   1.9e-07       1      44 [.     895     938 ..     891     941 .. 0.98
  21 !   23.4   0.1   6.1e-09   3.6e-05       1      41 [.     946     985 ..     946     993 .. 0.90
  22 !   25.2   0.8   1.6e-09   9.7e-06       1      49 []     995    1044 ..     995    1044 .. 0.91
  23 !   18.8   1.5   1.6e-07   0.00096       1      33 [.    1021    1053 ..    1021    1060 .. 0.94

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 6.8e-10
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 i+ +++ +ng+ l+++ ++++n+ e v+ A ++n  a s+as+eL+
  EFC37909.1  91 ICYKLIHHNGNLLQFAGDKIRNNEEMVILAARSNAVAVSFASDELK 136
                 6778999*************************************97 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 1.6e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 ++E+v  a ++n  a  ++s+eLk+++e+++ A+ + ++++
  EFC37909.1 113 NEEMVILAARSNAVAVSFASDELKRNREFAKVAILKGKSPY 153
                 79*****************************9998777766 PP

  == domain 3  score: 29.8 bits;  conditional E-value: 6.1e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D+Ei+l a++   +++k+lse+Lk  + ++ kA+ +ngt ++++++ +
  EFC37909.1 171 DEEIALIAIDCQRLSYKFLSERLKMKRIFIDKAISNNGTMIEFVPKQF 218
                 9********************************************975 PP

  == domain 4  score: 40.0 bits;  conditional E-value: 3.8e-14
     DUF4116   1 DrEivleavkkn....gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +rE++l+a+k+      ++l++++ee+k Dkei+l++v+ n+ +++y++e+Lr
  EFC37909.1 220 NRELILKAIKSTkhkkEEILRFIPEEFKFDKEIILQIVR-NCLVFRYIPEKLR 271
                 8*********77333366*********************.***********98 PP

  == domain 5  score: 40.2 bits;  conditional E-value: 3.3e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 D+Ei+l++v+++ ++++y++e+L+nD++++l+ vk+n+
  EFC37909.1 249 DKEIILQIVRNC-LVFRYIPEKLRNDRDVILQFVKSNK 285
                 9*********95.9**********************97 PP

  == domain 6  score: 53.0 bits;  conditional E-value: 3.4e-18
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+++l+ vk+n g  l+y+++++k+D+eiv++ vkqng++l y +e+L+
  EFC37909.1 273 DRDVILQFVKSNkGDTLQYVNDKFKSDREIVMESVKQNGCNLAYSHESLK 322
                 9*********9989*********************************997 PP

  == domain 7  score: 32.6 bits;  conditional E-value: 8e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 D+Eiv+ a+++n +a+k++s++Lk Dke+++  + +  ++l+++
  EFC37909.1 324 DKEIVTLAIRNNIEAIKHASDDLKFDKELLMSSITSTECFLKFL 367
                 9****************************************997 PP

  == domain 8  score: 0.7 bits;  conditional E-value: 0.072
     DUF4116  16 lky...lseeLknDkeivlkAvk 35 
                 lk+   +++ ++ D e++++ + 
  EFC37909.1 364 LKFltcVNPIIQYDDEFIIELIS 386
                 55533367888889999999875 PP

  == domain 9  score: 30.4 bits;  conditional E-value: 4e-11
     DUF4116   1 DrEivleavkkngsalky....lseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE +l++++  +s++ +    + e++k+D+eiv +A++ ++++l +as+e++
  EFC37909.1 433 DREHILQLLEYQPSSFVHhqdpIFEKFKSDREIVRRAIQLCPSSLTFASKEIQ 485
                 899999999999999999999999***************************86 PP

  == domain 10  score: 56.7 bits;  conditional E-value: 2.4e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv  a++ ++s+l+++s+e++nD+e++++A++ + ++++yas+eL+
  EFC37909.1 462 DREIVRRAIQLCPSSLTFASKEIQNDREFIKEAIQYHYNNFKYASKELQ 510
                 9**********************************************97 PP

  == domain 11  score: 41.8 bits;  conditional E-value: 1.1e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 DrE+++ea++ + +++ky+s+eL+nD+e++ + +++ g+ + ++s+e
  EFC37909.1 487 DREFIKEAIQYHYNNFKYASKELQNDIELINQVIERRGSYFIHISDE 533
                 9********************************************88 PP

  == domain 12  score: 23.4 bits;  conditional E-value: 6.1e-09
     DUF4116   1 DrEivleavkkngsalkylsee.LknDkeivlkAvkqng.talsyaseeL 48 
                 D E++ +++++ gs++ ++s+e LknD+++ lkA ++   ++++ + +eL
  EFC37909.1 512 DIELINQVIERRGSYFIHISDEtLKNDRNLFLKAARNTYhDIYENIGDEL 561
                 89******************888*************87757999999987 PP

  == domain 13  score: 8.0 bits;  conditional E-value: 0.00038
     DUF4116   1 DrEivleavkkngs.alkylseeLknDkeivlkAvkq 36 
                 Dr + l+a ++    +++++ +eL +D++++l+  kq
  EFC37909.1 538 DRNLFLKAARNTYHdIYENIGDELAHDRDLALEYTKQ 574
                 7888889999776449999*************97776 PP

  == domain 14  score: 26.8 bits;  conditional E-value: 5.2e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 DrEiv  a++  +  ++ +s eLknD+eivl  +k n 
  EFC37909.1 588 DREIVEIAIQMSSTEYEQASYELKNDREIVLMTLKANA 625
                 9******************************9999765 PP

  == domain 15  score: 15.2 bits;  conditional E-value: 2.2e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAv 34 
                 D Ei+ ea+k ng++l+ +++ ++ D eiv  A+
  EFC37909.1 640 DWEICYEACKANGKNLQSVPSQYQDDEEIVQVAI 673
                 669***************************8777 PP

  == domain 16  score: 33.7 bits;  conditional E-value: 3.6e-12
     DUF4116   1 DrEivleavkkn..gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eiv  a++++  g++++++s++Lk+Dk++v k + +n+ +++++s+eLr
  EFC37909.1 665 DEEIVQVAIDTDwtGEYFEFASNRLKSDKNFVSKLMDINPLIYCFISHELR 715
                 8899999999998899**********************************8 PP

  == domain 17  score: 50.3 bits;  conditional E-value: 2.3e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE++ +a++k g++l+y+s+e++nD+eivlkAv ++++a++  s+eL+
  EFC37909.1 717 DRELAIKAISKKGEVLQYCSSEYQNDREIVLKAVDNYPNAFYCSSKELQ 765
                 9****************************************9999*996 PP

  == domain 18  score: 14.5 bits;  conditional E-value: 3.7e-06
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 +E++l+a+++  + ++ l  +++nD ei+lkAv++n ++l+
  EFC37909.1 796 KEMALQAIENK-FKFNQLQFNMRNDYEIALKAVNKNMDNLK 835
                 899******85.55666666****************88887 PP

  == domain 19  score: 21.0 bits;  conditional E-value: 3.3e-08
     DUF4116  14 salkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++l +++ +++nD+ei+lk ++ +g+++  +s eL+
  EFC37909.1 854 YNLINIPLKFRNDREIALKSMQTHGDSFILLSRELQ 889
                 467779***********************9999996 PP

  == domain 20  score: 30.7 bits;  conditional E-value: 3.2e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 Dr+i+l avk+ +s++ ++ +eL++D +++ ++++ ng +l+y+
  EFC37909.1 895 DRQIMLMAVKSSSSIFSHACKELQQDYQFISQCIELNGQVLKYL 938
                 9******************************************7 PP

  == domain 21  score: 23.4 bits;  conditional E-value: 6.1e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 Dr +vl+av+  +  l +++ e+ +D+ei l Avk+++ ++
  EFC37909.1 946 DRNLVLKAVQF-PHTLLFIPLEYLKDREINLTAVKSCKESI 985
                 9*********9.89***********************9765 PP

  == domain 22  score: 25.2 bits;  conditional E-value: 1.6e-09
     DUF4116    1 DrEivleavkkngs.alkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  D Ei+l  ++++ +  + yl+ eL++++e++ k++++n+ ++ ya  +Lr
  EFC37909.1  995 DWEIALSSLSSDICdTIVYLPYELRSNREFISKCMEINKESIVYANYSLR 1044
                  569999999999766*************************9999987776 PP

  == domain 23  score: 18.8 bits;  conditional E-value: 1.6e-07
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkA 33  
                  +rE++ +++++n +++ y++ +L+ D+e++++ 
  EFC37909.1 1021 NREFISKCMEINKESIVYANYSLRYDREFLKEL 1053
                  8*****************************985 PP

>> DUF5615  Domain of unknown function (DUF5615)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.36   2.1e+03      35      48 ..     322     335 ..     302     336 .. 0.77
   2 ?   -2.0   0.0      0.54   3.2e+03      25      46 ..     449     471 ..     435     473 .. 0.71
   3 ?   -3.1   0.0       1.2   6.9e+03      29      46 ..     580     597 ..     572     599 .. 0.72
   4 ?   -0.7   0.0       0.2   1.2e+03      30      48 ..     658     676 ..     647     678 .. 0.79
   5 !   11.6   0.0     3e-05      0.18      11      61 ..     743     792 ..     740     802 .. 0.80
   6 ?   -2.8   0.0      0.92   5.5e+03      28      52 ..     886     910 ..     882     912 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.36
     DUF5615  35 asDeeileyAkeed 48 
                  +D+ei+ +A++++
  EFC37909.1 322 KNDKEIVTLAIRNN 335
                 47*********998 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.54
     DUF5615  25 lhvrelgleg.asDeeileyAke 46 
                 +h ++   e+  sD+ei+++A++
  EFC37909.1 449 VHHQDPIFEKfKSDREIVRRAIQ 471
                 5555555454489******9986 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.2
     DUF5615  29 elglegasDeeileyAke 46 
                 +l  +   D+ei+e+A++
  EFC37909.1 580 SLPFDFKHDREIVEIAIQ 597
                 555555689****99986 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.2
     DUF5615  30 lglegasDeeileyAkeed 48 
                 +  +  +Deei+++A++ d
  EFC37909.1 658 VPSQYQDDEEIVQVAIDTD 676
                 5566689********9876 PP

  == domain 5  score: 11.6 bits;  conditional E-value: 3e-05
     DUF5615  11 prlvellreaghdvlhvrelglegasDeeileyAkeedriivTkDkDFgel 61 
                 +++v +  ++++++ +  + +l+ ++D+ei+e A+++++ i T+ + + + 
  EFC37909.1 743 REIVLKAVDNYPNAFYCSSKELQ-INDSEIFETAIRNGLSIHTNEETYFQS 792
                 56777788899999999666665.********************9665554 PP

  == domain 6  score: -2.8 bits;  conditional E-value: 0.92
     DUF5615  28 relglegasDeeileyAkeedriiv 52 
                 rel+le   D++i+ +A +    i+
  EFC37909.1 886 RELQLEFSHDRQIMLMAVKSSSSIF 910
                 677888899*****99998776665 PP

>> ROQ_II  Roquin II domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.29   1.7e+03      12      26 ..     322     336 ..     316     338 .. 0.83
   2 ?    3.7   0.1    0.0094        56      12      23 ..     586     597 ..     583     600 .. 0.90
   3 ?    2.6   0.1      0.02   1.2e+02      13      25 ..     664     676 ..     661     678 .. 0.87
   4 ?   -1.4   0.0      0.36   2.2e+03      13      30 ..     767     784 ..     765     794 .. 0.87
   5 ?   -1.8   0.0      0.46   2.8e+03      12      23 ..     893     904 ..     889     907 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.29
      ROQ_II  12 ehDaqivqvAfeagl 26 
                 + D++iv +A+ +++
  EFC37909.1 322 KNDKEIVTLAIRNNI 336
                 67********98765 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0094
      ROQ_II  12 ehDaqivqvAfe 23 
                 +hD +iv++A++
  EFC37909.1 586 KHDREIVEIAIQ 597
                 8*********97 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.02
      ROQ_II  13 hDaqivqvAfeag 25 
                  D +ivqvA++++
  EFC37909.1 664 DDEEIVQVAIDTD 676
                 599*******987 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 0.36
      ROQ_II  13 hDaqivqvAfeaglrlsp 30 
                  D++i + A+ +gl +  
  EFC37909.1 767 NDSEIFETAIRNGLSIHT 784
                 5999*********99875 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 0.46
      ROQ_II  12 ehDaqivqvAfe 23 
                  hD qi+ +A+ 
  EFC37909.1 893 SHDRQIMLMAVK 904
                 7*******9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1083 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1167  (0.0650901); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.93u 0.34s 00:00:01.27 Elapsed: 00:00:00.56
# Mc/sec: 5791.86
//
Query:       EFC37910.1  [L=335]
Description: hypothetical protein NAEGRDRAFT_44817 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-97  326.9   0.1    1.2e-80  271.1   0.0    3.0  2  Actin     Actin
  ------ inclusion threshold ------
       0.13   12.7   0.0        7.7    7.0   0.0    2.5  2  FtsA      Cell division protein FtsA
       0.15   10.8   0.0       0.37    9.6   0.0    1.6  2  MreB_Mbl  MreB/Mbl protein


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.9   0.0   1.5e-17   8.9e-14       4      77 ..       3      76 ..       1      77 [. 0.91
   2 !  271.1   0.0     2e-84   1.2e-80     101     407 .]      73     335 .]      72     335 .] 0.96

  Alignments for each domain:
  == domain 1  score: 50.9 bits;  conditional E-value: 1.5e-17
       Actin  4 vsavVlDnGssttraGyage..daPkavipslvgkprgrkveaklyvgdealtkrpelevrspvedGvvedwdave 77
                 +a+++DnGs+t+++G a e  ++P++++p+lvg+ +++++  +  vgdea++kr+  ++++p+e+ v+++ +av+
  EFC37910.1  3 KTAIIIDNGSCTMKVGIANEqdNTPTSIFPTLVGHHKKSTS--TTIVGDEAIAKRGICTLKYPIEHCVITNIEAVR 76
                579***************752269*************9965..9*****************************987 PP

  == domain 2  score: 271.1 bits;  conditional E-value: 2e-84
       Actin 101 epplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtpryl 199
                 e++ +p+ +re++++ivfE+f++ ++y+a + vl++fasgk++g+v+D+G+sv+ +vpV++Gy+L++ai + +++G+ +te+l + +            
  EFC37910.1  73 EAVREPKCNRERMTQIVFEEFNISSFYVAMQGVLALFASGKTSGIVLDLGESVSRAVPVYEGYALTHAISSWNFAGREITEYLVQAFAGC--------- 162
                 7888999**********************************************************************************5......... PP

       Actin 200 ikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleee 298
                                      +  y + + + v++++K ++c+v+ d+   +e++++  ++sYeLPDgs i++g eRfk++E LF+p+l   +s     
  EFC37910.1 163 ---------------------KIPYFAEHPTDVMTDMKHNICYVALDFD--QENEKAVTDVSYELPDGSLINIGCERFKCTEELFNPNL---DSH---- 231
                 .....................3368888999****************97..7888899*****************************76...333.... PP

       Actin 299 kskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEq 397
                     +gi+e ++++i +cd+d+r+++++ni+++GG++++ gl+eR+ekel++la+++vk+++ ap+  rkys+W+GGS+L+sl++f+ +w+s +EY+E 
  EFC37910.1 232 ----SGIHEQVFNSIRKCDMDVRKDMFSNIILAGGTTMFTGLSERVEKELSALAPSNVKINVEAPP-FRKYSVWLGGSLLSSLSSFEPMWISCKEYDEI 325
                 ....5*************************************************************.******************************** PP

       Actin 398 Gssvverkck 407
                 G+s+v+rkc+
  EFC37910.1 326 GPSIVHRKCF 335
                 *********6 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1     0.022   1.3e+02       2      36 ..       7      41 ..       6      78 .. 0.79
   2 ?    7.0   0.0    0.0013       7.7       1      86 [.     117     277 ..     117     302 .. 0.65

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.022
                EEEE-SSSEEEEEEETTEEEEEEEES-.-HHHHHHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxx RF
        FtsA  2 lvDiGagktdvavaedgalvhlrvigv.ggngitkd 36
                ++D G+ +++v +a+++  + +++ ++    + +k+
  EFC37910.1  7 IIDNGSCTMKVGIANEQDNTPTSIFPTlV-GHHKKS 41
                79**************9988899999953.333444 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0013
                 EEEEE-SSSEEEE.EEETTEEEE.EEEES--HHHHHHHHHHHH.........T--HHHHHHHHHHH--S--.........EEEEEHHHHH......... CS
                 xxxxxxxxxxxxx.xxxxxxxxx.xxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxx.........xxxxxxxxxx......... RF
        FtsA   1 alvDiGagktdva.vaedgalvh.lrvigvggngitkdiakal.........rtaveeAerikikyGsala.........ekeigrkels......... 70 
                 +++D+G + + ++ v+e+ al+h +++ +++g+ it+ +++a+           + +    +k+++ ++                    +         
  EFC37910.1 117 IVLDLGESVSRAVpVYEGYALTHaISSWNFAGREITEYLVQAFagckipyfaEHPTDVMTDMKHNICYVALdfdqenekaV--------Tdvsyelpdg 207
                 5899**999998846666667779999999********8887766555555566777777777443333335544432220........1333555555 PP

                 ......................................................GGGGSTTHHHHHHHHH CS
                 ......................................................xxxxxxxxxxxxxxxx RF
        FtsA  71 ......................................................ggsalpnleelaeral 86 
                                                                       g+++  +l e +e+ l
  EFC37910.1 208 slinigcerfkcteelfnpnldshsgiheqvfnsirkcdmdvrkdmfsniilagGTTMFTGLSERVEKEL 277
                 5666666666666666666666666666777777777777777777777777777777777777777775 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.27   1.6e+03      27      72 ..      32      73 ..       4      77 .. 0.59
   2 ?    9.6   0.0   6.1e-05      0.37     250     297 ..     231     277 ..     199     290 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.27
                ES-EEEETTT--EEEESHHHHTTTTS-GTTEEEE-SEETTEESSHH CS
    MreB_Mbl 27 psvvAikkktkkvlavGeeAkkmlgktpgnikavrPlkdGviadle 72
                p++v  +kk+++ + vG+eA    g      +   P+++ vi+++e
  EFC37910.1 32 PTLVGHHKKSTSTTIVGDEAIAKRG----ICTLKYPIEHCVITNIE 73
                6677777777777778887754322....33344566666666666 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 6.1e-05
                 HHHHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHH CS
    MreB_Mbl 250 vsaiveavkevLektppeLaadivdrgivltGGgallkgldkllseet 297
                  s i e+v + ++k+  +  +d++ + i+l+GG++++ gl + +++e+
  EFC37910.1 231 HSGIHEQVFNSIRKCDMDVRKDMFSN-IILAGGTTMFTGLSERVEKEL 277
                 5789999***************9987.8999************99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1905.51
//
Query:       EFC37911.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.058   14.0   0.1       0.37   11.4   0.0    2.3  2  VCBS      Repeat domain in Vibrio, Colwellia, Bradyrhizobium 
       0.09   12.6   0.0        1.3    8.8   0.1    2.3  2  B12D      NADH-ubiquinone reductase complex 1 MLRQ subunit


Domain annotation for each model (and alignments):
>> VCBS  Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   4.1e-05      0.37       4      35 ..      76     111 ..      74     132 .. 0.81
   2 ?   -0.6   0.0      0.24   2.1e+03      23      30 ..     181     188 ..     171     214 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4.1e-05
        VCBS   4 gDGrlDlvva.....ndgglrvyrnngdGtftdvtkt 35 
                 +DG+ D++++     n+++ +v+rn++  ++++ +++
  EFC37911.1  76 NDGKIDILALeakhiNYSPDVVWRNQK-RKLQKLREQ 111
                 9********99999999********95.577777765 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.24
        VCBS  23 nngdGtft 30 
                 n+g+G+f 
  EFC37911.1 181 NQGNGSFW 188
                 66666664 PP

>> B12D  NADH-ubiquinone reductase complex 1 MLRQ subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.1   0.00015       1.3      25      47 ..      88     108 ..      84     122 .. 0.86
   2 ?    1.1   0.0     0.038   3.4e+02      11      31 ..     192     211 ..     190     232 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00015
        B12D  25 RllltnPDVrwnkknnpepWnkl 47 
                 +++ ++PDV+w++++++   +kl
  EFC37911.1  88 KHINYSPDVVWRNQKRKL--QKL 108
                 6899***********997..665 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.038
        B12D  11 figagvggavfylvRllltnP 31 
                 ++ ++v++ ++y++ +  +nP
  EFC37911.1 192 AVVGAVSLGAMYVAANT-NNP 211
                 67788888888888776.444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1033  (0.0576162); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1373.06
//
Query:       EFC37912.1  [L=919]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.2e-47  159.6   0.2    7.2e-47  159.6   0.2    2.3  3  AAA_12         AAA domain
    8.6e-30  104.4   5.9    1.2e-13   51.4   0.0    3.7  4  AAA_11         AAA domain
    3.7e-11   43.6   0.4    3.6e-08   33.8   0.0    3.7  3  AAA_19         AAA domain
    4.7e-10   39.5   0.0    3.5e-09   36.6   0.0    2.4  2  AAA_30         AAA domain
    0.00054   19.5   0.0      0.011   15.2   0.0    2.4  2  PhoH           PhoH-like protein
     0.0014   18.7   0.0     0.0014   18.7   0.0    2.8  4  ResIII         Type III restriction enzyme, res subunit
      0.002   17.7   0.7      0.028   13.9   0.0    2.4  2  AAA_7          P-loop containing dynein motor region
     0.0026   17.4   0.0     0.0026   17.4   0.0    3.3  3  UvrD-helicase  UvrD/REP helicase N-terminal domain
     0.0028   17.9   0.1       0.99    9.7   0.0    3.9  4  AAA_22         AAA domain
     0.0095   15.7   0.0      0.043   13.6   0.0    2.1  2  DEAD           DEAD/DEAH box helicase
  ------ inclusion threshold ------
      0.018   14.7   0.0      0.042   13.4   0.0    1.5  1  AAA_25         AAA domain
      0.024   15.1   0.0       0.14   12.6   0.0    2.3  2  AAA            ATPase family associated with various cellular


Domain annotation for each model (and alignments):
>> AAA_12  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       4.2   6.3e+03      67     106 ..      46      97 ..      26     105 .. 0.53
   2 ?   -1.0   0.1      0.77   1.1e+03      95     149 ..     485     536 ..     481     537 .. 0.81
   3 !  159.6   0.2   4.9e-50   7.2e-47       2     198 ..     645     859 ..     644     860 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4.2
      AAA_12  67 lvfidv............ekseeekekke...ksyiNeeEaelvvklvekllkkg 106
                 +v+ d+            ++ +++k   +   ks++N +  ++    ++ ++++ 
  EFC37912.1  46 VVVADTtlnlantappqpKRTRKKK---AdikKSMVNANASTTFKAALNVVVQHA 97 
                 4444444444444544332222233...134488888776666666666555554 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.77
      AAA_12  95 vvklvekllkkgseeerkkigvitpYraqvellkkklkekeeeksekeievntvd 149
                 v +++ +++k+ +++   ki + +p ++ ++++ ++l +++ +  +k +++n+v 
  EFC37912.1 485 VSQCILEIMKQDPNH---KILICAPSNQAADIIVERLVDSNLNPLVKMMRMNSVQ 536
                 566777777777666...9***************999998888888888888885 PP

  == domain 3  score: 159.6 bits;  conditional E-value: 4.9e-50
      AAA_12   2 erSlferllkke..kekvvlLdtqYRmhpeIsrfpsklfYkgkLkdae.svkkrele.aqealeepleplvfidvekseeekekkeksyiNeeEaelvv 96 
                  +Sl+e+l+k +    +++ L++ YR hp+I++  s+ fY+++L ++  ++++ +l+  +  le+p+ p++f++v+++e++++++  s++N++E+++++
  EFC37912.1 645 GESLLEHLVKLGdnCCSITQLQQSYRAHPKIMQVYSSVFYNNSLISSCtDINSANLFiNNPILENPQVPMLFYHVKGDEKRDNDS-PSWYNSKEIQVLM 742
                 68*********977788999***********************9887735555555555778999************99999987.************* PP

      AAA_12  97 klvekllkkgsee........erkkigvitpYraqvellkkklkekeeeksekeievntvdgfQGrekdviilslVRsn........ekkeigflkder 179
                 + +++++k+g            +++ig+itpYr+q+e +kk l+++ +   +k+i v+t ++fQG+e++vi+l++VRs+        +k ++gfl++ +
  EFC37912.1 743 DKLDEIVKSGLVFnskhnqynPEHEIGIITPYRKQAEEIKKLLRKSTNP-LYKKIFVGTTEQFQGQERRVILLTTVRSSstegleqdSKFKLGFLQNPK 840
                 *********988888899999789********************65555.6899************************8555555445558******** PP

      AAA_12 180 rlNValTRAkskliivGnk 198
                 rlNVa++RA s ++ivGn+
  EFC37912.1 841 RLNVAISRAISLMVIVGNA 859
                 *****************97 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   3.2      0.48   7.2e+02      99     149 ..      89     139 ..      24     196 .. 0.64
   2 ?   -3.4   0.1       4.4   6.6e+03     118     153 ..     300     332 ..     277     357 .. 0.45
   3 !   51.4   0.0   8.4e-17   1.2e-13      16      96 ..     467     535 ..     459     548 .. 0.83
   4 !   51.1   0.0     1e-16   1.5e-13     179     260 ..     552     636 ..     543     637 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.48
      AAA_11  99 riseavksvsleekvekrlekeekaqlakeiskeleklakelrafeeeeek 149
                 + +  v+  s ++ v +++++  +++  k++sk++++ +++ ++ + ++++
  EFC37912.1  89 ALNVVVQHASASSNVAHKQTSAGTTTTGKTTSKNSNRRKRAKKQATPQQSE 139
                 344555556666666666655555555555555554444444444333333 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 4.4
      AAA_11 118 ekeekaqlakeiskeleklakelrafeeeeekeklk 153
                 ++++  +++   ++ +++l+ el++ +++   ++++
  EFC37912.1 300 DNKKILEKHAMNAQLKNELSGELKQGTKV---TQQE 332
                 33332222222222222222222222222...1222 PP

  == domain 3  score: 51.4 bits;  conditional E-value: 8.4e-17
      AAA_11  16 eseitliqGPPGtgKTktivellsqllsrrkseeeksakpriLvCapSNaAvDellerllrglldsegekykpkivRvgne 96 
                 +++++++ GPPGtgKT+++ + + ++       ++++++++iL+CapSN A D ++erl++     +  +  +k++R+ + 
  EFC37912.1 467 HRALSMFFGPPGTGKTFVVSQCILEI-------MKQDPNHKILICAPSNQAADIIVERLVD-----SNLNPLVKMMRMNSV 535
                 56689999******************.......579*************************.....445555666666554 PP

  == domain 4  score: 51.1 bits;  conditional E-value: 1e-16
      AAA_11 179 keleeaeesleeevldeaeivltTlsgagsklleklak.kfdvviIDEAaqavEpstliPlrlga..kkvvLvGDpkQLpatvis 260
                 ++l++  e  e + + + +++++T++++g    + ++   f  +iIDE + +v p++liP++l+     vvL+GDpkQL ++v s
  EFC37912.1 552 NKLDQGFEIPELHEIAKYDVIISTCTSSGYLYSKGVKPgHFSHIIIDESGESVIPEALIPFSLKGdnTVVVLAGDPKQLGPIVRS 636
                 55555566666789999***********999988887679*********************8888667799***********987 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   2.2      0.44   6.6e+02      92     121 ..     338     370 ..      65     377 .. 0.67
   2 !   33.8   0.0   2.4e-11   3.6e-08       9     142 ..     467     631 ..     460     635 .. 0.74
   3 ?    2.8   0.0     0.093   1.4e+02      40      93 ..     763     847 ..     748     876 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.44
      AAA_19  92 e....eaeeekklqeeellivDEfqdvd.elqyrL 121
                      ++ +++ l  ++ll v E+q+++   qy L
  EFC37912.1 338 StndmYTYTHNLL--GTLLHVEEAQMIYdIKQYDL 370
                 1444444555566..88999999999998888877 PP

  == domain 2  score: 33.8 bits;  conditional E-value: 2.4e-11
      AAA_19   9 kekvllvtaGpGtGKTrvlkhivallvelggvkpeeillvaftgrAakelrerlaalgae...................................atTi 72 
                 ++ + +  ++pGtGKT v+ + + ++ ++   + ++il++a+ ++Aa+ + erl   +++                                   +  +
  EFC37912.1 467 HRALSMFFGPPGTGKTFVVSQCILEIMKQD--PNHKILICAPSNQAADIIVERLVDSNLNplvkmmrmnsvqrdpntftkrwiikfsnkldqgfeIPEL 563
                 56677889***********99998888877..569*******************555555899999999999998888877777777777777777777 PP

      AAA_19  73 Hrlalldfddlltealelleeaeeekklqeee.llivDEfqdvdelqyrLlkallgekkklllvGDpdQli 142
                 H++a  d+   + +  ++l +++  k+   ++ ++i+DE+ +    +  +   l+g+++ ++l GDp+Ql 
  EFC37912.1 564 HEIAKYDVIISTCTSSGYL-YSKGVKPG--HFsHIIIDESGESVIPEALIPFSLKGDNTVVVLAGDPKQLG 631
                 7774443333333334443.44454555..445******999875555555677778888999******85 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.093
      AAA_19  40 vkpeeillvaftgrAakelrerlaalgae......................atTiHrlalldfddlltealelle.........e 93 
                  + +ei ++++ ++ a+e+++ l++ + +                       tT+ + ++ +++++ + +l++l+         +
  EFC37912.1 763 NPEHEIGIITPYRKQAEEIKKLLRKSTNPlykkifvgtteqfqgqerrvilLTTVRSSSTEGLEQDSKFKLGFLQnpkrlnvaiS 847
                 3457999**************9988888899999999999999999999988888888888888888888888886655544441 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.6       2.5   3.7e+03      10      36 ..      94     122 ..      83     135 .. 0.64
   2 !   36.6   0.0   2.4e-12   3.5e-09      19     133 ..     469     635 ..     464     641 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.5
      AAA_30  10 vealltsgdrvavltGpAG...tGKttalk 36 
                 v+++ +s++ va  +  AG   tGKtt+ +
  EFC37912.1  94 VQHASASSN-VAHKQTSAGtttTGKTTSKN 122
                 455555554.65556666633358888755 PP

  == domain 2  score: 36.6 bits;  conditional E-value: 2.4e-12
      AAA_30  19 rvavltGpAGtGKttalkal.reaweaa.ggrviglAptgkaAkvLaeelgieastiakllkrlk.................................. 81 
                  +++  Gp+GtGKt+++++   e+++++ +++++++Ap+++aA+ + e l    s+++ l+k ++                                  
  EFC37912.1 469 ALSMFFGPPGTGKTFVVSQCiLEIMKQDpNHKILICAPSNQAADIIVERLV--DSNLNPLVKMMRmnsvqrdpntftkrwiikfsnkldqgfeipelhe 565
                 578889***********9987999999999***************776432..2333333333333336666667777788888899999999999999 PP

      AAA_30  82 ..................grarlepg..tllivDEagmvdtkqlaallkaaekagakvilvGDerQlasVea 133
                                   + + ++pg  + +i+DE+g   + ++   ++   + ++ v+l+GD++Ql+++ +
  EFC37912.1 566 iakydviistctssgylyS-KGVKPGhfSHIIIDESGESVIPEALIPFSLKGD-NTVVVLAGDPKQLGPIVR 635
                 999999***********62.5667766699********999999888887777.9**************976 PP

>> PhoH  PhoH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   7.2e-06     0.011      16      61 ..     465     510 ..     459     531 .. 0.88
   2 ?    1.3   0.0      0.14     2e+02     121     158 ..     593     630 ..     591     666 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 7.2e-06
                 HHH-SEEEEE--TTSSTTHHHHHHHHHHHHTTS-SEEEEEE-S--T CS
        PhoH  16 lkkndivfaiGpaGtGKtylavalavealkkkkvkriiltrpavea 61 
                 l++  + + +Gp GtGKt++  ++ +e++k++  ++i++  p+ +a
  EFC37912.1 465 LMHRALSMFFGPPGTGKTFVVSQCILEIMKQDPNHKILICAPSNQA 510
                 557789999******************************9998766 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.14
                 EEEEE-SGGG--HHHHHHHHTTB-TT-EEEEEE----- CS
        PhoH 121 afvilDEAQnttkeqmkmfltRlGenskvvvtGdvtqi 158
                 + +i+DE+ +    +  +  +  G n+ vv++Gd++q 
  EFC37912.1 593 SHIIIDESGESVIPEALIPFSLKGDNTVVVLAGDPKQL 630
                 56999999888777777777778*************97 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       2.4   3.6e+03     110     113 ..     115     118 ..      37     196 .. 0.63
   2 ?   -3.1   0.1       4.5   6.7e+03      72     117 ..     312     365 ..     295     390 .. 0.50
   3 !   18.7   0.0   9.3e-07    0.0014      28     141 ..     472     600 ..     417     605 .. 0.74
   4 ?   -2.0   0.1       2.1   3.2e+03      73     111 ..     780     817 ..     757     882 .. 0.52

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.4
                 EHHH CS
      ResIII 110 tiqs 113
                 t ++
  EFC37912.1 115 TGKT 118
                 2222 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 4.5
                 HHGGGGTGG....GEEEESSS-B--................-SEEEEEHHHHHHT CS
      ResIII  72 eefkkflseaykeigkkvsgdkkka.........kekdstnkkilvttiqsldad 117
                  ++k+ ls + k +g+kv++++ ++         + ++   + ++v++ q+++ +
  EFC37912.1 312 AQLKNELSGELK-QGTKVTQQEPNEhvstndmytYTHNLLGTLLHVEEAQMIYDI 365
                 333444444432.444444444444333333333344444444555555555555 PP

  == domain 3  score: 18.7 bits;  conditional E-value: 9.3e-07
                 EEEESTTSTHHHHHHHHHHHH-S.....-EEEEESSH....HHHHHHHHHG............GGGTGG................GEEEESSS-B--.. CS
      ResIII  28 likmaTGtGKTlvaaklierllkkgkeekflflvprk....slleqtleef............kkflseayke............igkkvsgdkkka.. 96 
                 ++  + GtGKT+v  + i +++k+ ++ k+l+ +p++    +++e++ +               +       +             ++k+++    +  
  EFC37912.1 472 MFFGPPGTGKTFVVSQCILEIMKQDPNHKILICAPSNqaadIIVERLVDSNlnplvkmmrmnsVQ-------RdpntftkrwiikFSNKLDQG---Fei 560
                 566788******************************96665667777743344444443332222.......122333445533333333333...244 PP

                 ........-SEEEEEHHHHHHTH........HHHTTT-SEEEEETG CS
      ResIII  97 .kekdstnkkilvttiqsldadseeeeeeseellrdrfdviiiDEa 141
                  + +++ + +++++t  s           s+  ++++f  iiiDE+
  EFC37912.1 561 pELHEIAKYDVIISTCTSSGYLY------SKGVKPGHFSHIIIDES 600
                 48888888888888888776666......88899999999999995 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 2.1
                 HGGGGTGG.....GEEEESSS-B--.......-SEEEEEH CS
      ResIII  73 efkkflseayke.igkkvsgdkkkakekdstnkkilvtti 111
                 e+kk+l + ++   +k++ g ++++  + ++ + il+tt+
  EFC37912.1 780 EIKKLLRKSTNPlYKKIFVGTTEQF--QGQERRVILLTTV 817
                 3333333333333233333333333..2233333333333 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.7      0.18   2.6e+02       6      61 ..      70     132 ..      66     141 .. 0.62
   2 !   13.9   0.0   1.9e-05     0.028      31      84 ..     466     521 ..     445     530 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.18
       AAA_7   6 eakfseilVptvdtvrysyllelllknk.......kpvllvGptGtGKtviikdllkkldkek 61 
                 +a++++ +V+ + ++ ++  l+ ++++        ++    G+t tGKt+  ++  +k  k++
  EFC37912.1  70 KADIKKSMVNANASTTFKAALNVVVQHAsassnvaHKQTSAGTTTTGKTTSKNSNRRKRAKKQ 132
                 556666677777777777766666665411111114456789999999999888666655555 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 1.9e-05
       AAA_7  31 knkkpvllvGptGtGKtviikd.llkkldkekyl.sltinfsaqtsanqlqdiies 84 
                  ++   ++ Gp GtGKt ++++ +l+ ++++    +l++  s+q     + ++++s
  EFC37912.1 466 MHRALSMFFGPPGTGKTFVVSQcILEIMKQDPNHkILICAPSNQAADIIVERLVDS 521
                 5666789***************8787777554430333344444444445555555 PP

>> UvrD-helicase  UvrD/REP helicase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   1.7e-06    0.0026      22      75 ..     477     528 ..     467     568 .. 0.79
   2 ?   -2.4   0.0       1.7   2.6e+03     256     294 ..     591     629 ..     590     630 .. 0.67
   3 ?   -3.1   0.0       2.8   4.2e+03      48      68 ..     768     796 ..     753     877 .. 0.61

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.7e-06
                    TTSSHHHHHHHHHHHHHHTSSSTGGGEEEEESSHHHHHHHHHHHHH.....HHHHCCHH CS
  UvrD-helicase  22 AGsGKTfvlaerilrlikeeeiepdrilvvTFTnkAaeElkeRiee.....alkkaeqe 75 
                    +G+GKTfv+ + il+ +k+    +++il+    n+Aa+ + eR+       +     ++
     EFC37912.1 477 PGTGKTFVVSQCILEIMKQD--PNHKILICAPSNQAADIIVERLVDsnlnpL-----VK 528
                    8*******************..8999*****************988444442.....33 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.7
                    HSSEEEESSGGG-BHHHHHHHHHHHTTTTTEEEEE-GGG CS
  UvrD-helicase 256 rykeiliDEyQDTnkiQyrilkllasgheelfmvGDpkQ 294
                    ++ +i iDE        + i   l  ++  +++ GDpkQ
     EFC37912.1 591 HFSHIIIDESGESVIPEALIPFSLKGDNTVVVLAGDPKQ 629
                    677788888766544444444556666666999999999 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.8
                    EEEEESSHHHHHHHHHHHHH........H CS
  UvrD-helicase  48 ilvvTFTnkAaeElkeRiee........a 68 
                    i ++T  +k aeE+k+ +++        +
     EFC37912.1 768 IGIITPYRKQAEEIKKLLRKstnplykkI 796
                    55666666666666666666444443330 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.12   1.8e+02      12      84 ..     111     197 ..     110     218 .. 0.57
   2 ?   -2.3   0.0       3.4     5e+03      67     103 ..     321     362 ..     306     396 .. 0.69
   3 !    9.7   0.0   0.00066      0.99       5      49 ..     468     507 ..     464     537 .. 0.72
   4 ?   -0.3   0.0      0.78   1.2e+03      82     118 ..     842     877 ..     817     883 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.12
      AAA_22  12 GesGtGKTtllrrlleqldeeakaee............................erpevvfvtlpsstsskdllrellralglelkaerlsseelleal 82 
                 G + tGKTt+ +  +++  + ++                                           ++  +d+ + + + l++++k    +++ ll+++
  EFC37912.1 111 GTTTTGKTTSKNSNRRKRAKKQAT-PqqsestpppsvsnnnnnnnngtsmngllL----------DENRKRDIIHFVTSTLDVPRKM---DTKKLLKMV 195
                 667799999988888876443333.247888888888877776533333333330..........3335555566666666655555...555555554 PP

      AAA_22  83 eq 84 
                 ++
  EFC37912.1 196 HK 197
                 44 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 3.4
      AAA_22  67 elka......erlsseellealeqalraravielliiDEaqhl 103
                 elk       ++ +++   + ++ + ++     ll ++Eaq +
  EFC37912.1 321 ELKQgtkvtqQEPNEHVSTNDMYTYTHNLLG-TLLHVEEAQMI 362
                 3333555563334444444888888888888.89999999876 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00066
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlps 49 
                 + + + +G++GtGKT+++ +   +  +     + + + +++++ps
  EFC37912.1 468 RALSMFFGPPGTGKTFVVSQCILEIMK-----QDPNHKILICAPS 507
                 5667899*********99887766532.....2344455555555 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.78
      AAA_22  82 leqalraravielliiDEaqhlrs.eealeeLrsllnl 118
                 l+ a++++    ++i+ +a+ l s +e+++++ +++ +
  EFC37912.1 842 LNVAISRAIS-LMVIVGNAELL-SiDEHWKKIIEIYRN 877
                 5555566666.899********.889999999988874 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.0   2.9e-05     0.043      22      71 ..     476     522 ..     470     603 .. 0.69
   2 ?   -3.3   0.0       4.5   6.7e+03      53      74 ..     771     792 ..     762     816 .. 0.55

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.9e-05
                 STTSSHHHHHHHHHHHHHHHSTTSTS-EEEEEESSHHHHHHHHHHHHHHT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  22 eTGsGKTlaflipvlqivyetkgktgpkalivePtreLaeqtlnnlkkfk 71 
                 + G+GKT + +  +l+i+   k++++ k+li +P+ + a  ++++l  + 
  EFC37912.1 476 PPGTGKTFVVSQCILEIM---KQDPNHKILICAPSNQAADIIVERLVDSN 522
                 78*************999...79*************99999998875544 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 4.5
                 EESSHHHHHHHHHHHHHHTTTS CS
                 xxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  53 vePtreLaeqtlnnlkkfkkyi 74 
                 ++P r+ ae++ + l+k+++++
  EFC37912.1 771 ITPYRKQAEEIKKLLRKSTNPL 792
                 5555555555555555555542 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   2.8e-05     0.042      33      62 ..     468     497 ..     463     513 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.8e-05
      AAA_25  33 gelallaGapgtGKttlaldlalavatGkp 62 
                  +l++++G+pgtGKt+++++  l++++ +p
  EFC37912.1 468 RALSMFFGPPGTGKTFVVSQCILEIMKQDP 497
                 6899*****************999997666 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0     9e-05      0.14       2      21 ..     472     491 ..     471     556 .. 0.87
   2 ?   -2.0   0.0       2.9   4.3e+03      62      75 ..     740     760 ..     725     817 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 9e-05
                 EEESSTTSSHHHHHHHHHHH CS
         AAA   2 llyGppGtGKTllakavake 21 
                 +++GppGtGKT ++++ + e
  EFC37912.1 472 MFFGPPGTGKTFVVSQCILE 491
                 699**********9876655 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.9
                 EEEETGGGHHHHH.......T CS
         AAA  62 lfiDEidalaksr.......s 75 
                 +++D +d+++ks        +
  EFC37912.1 740 VLMDKLDEIVKSGlvfnskhN 760
                 677777777777765543222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (919 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1456  (0.0812092); expected 358.6 (0.02)
Passed bias filter:                      554  (0.0308997); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.96u 0.35s 00:00:01.31 Elapsed: 00:00:00.55
# Mc/sec: 4997.87
//
Query:       EFC37913.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.9e-85  285.1   0.0    1.1e-84  284.8   0.0    1.0  1  HSP70     Hsp70 protein


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  284.8   0.0   5.9e-89   1.1e-84       1     482 [.       8     488 ..       8     503 .. 0.91

  Alignments for each domain:
  == domain 1  score: 284.8 bits;  conditional E-value: 5.9e-89
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXTTSE.........EETHHHHHCTTTTGGGEEEXGGGTTTXBTTS.HHHHHHHTTXSSEE CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrttPsvvaFtkker.........lvGeaAkrqavtnpkntvfsvKrliGrkfsd.pevqkeikelpykv 89 
                 ++GiD G   +  av  +++ie i n+ g+  tP ++aF ++           l+G++A +   +np+  + ++K+liG++f+d +e+ ++ + +p+k+
  EFC37913.1   8 IVGIDFGGSHCRAAVYIKDHIEYIPNKFGKYETPTCLAFLDESSsssvseskiLIGQEALEYSLVNPHCCFWDFKKLIGKTFHDdDEFSSQERRWPFKI 106
                 69*************************************7652212222223389***************************86257999********* PP

                 EEETTSBEEEEEEETTEEEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSSSCEEE CS
       HSP70  90 vkkengkavveveaagekftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkdkernv 188
                  +ke+g + + v   + +++ +++ + +Lk+lk++ae yl++ vt++++++P Y+ + qR  +k Ag++AGL++ R + ++ A    Y l k++ er v
  EFC37913.1 107 IRKEDGTIRLGVI--NGELSISEMIGLILKELKQDAERYLNTLVTEIIVSIPNYYSNCQRIIMKKAGEYAGLKIARFIHDTSASCFQY-LWKEHGERRV 202
                 ***8888888877..6689999******************************************************************.778888**** PP

                 EEEEEXSSXEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTE CS
       HSP70 189 lvyDlGggtfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrlkeaaekaKkeLSsskqteinleietvdedgk 287
                  ++DlG +   +Si+ +e+ +fe +   g +++GG   De lv++++e+f k+ +  l++++  ++rl+ a+e+aKk LS+  + e+++++e++++ g+
  EFC37913.1 203 FLFDLGRSGCSASIMIVESDIFETRTSEGFSNVGGSLLDESLVNYCCEQFYKSFKKHLQENPISMRRLNLACEEAKKRLSN--ELETKISLESLMD-GN 298
                 *********************************************************************************..788888899***9.** PP

                 EEEEEEEHHHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTTCHHB.SSSHTTTHHHHHHHHHHHHHCTCGCSHCCE CS
       HSP70 288 dlseklsRakfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfgkeps.ktvnpDeavaiGAAvqagvlsgeeevkdll 385
                 d+++++sR+ feel+ ++++++++ v+++   + ++k+eid+v+ vGG   iPk++el++++fgk +  k + p e va G A+ +g+l g    ++ l
  EFC37913.1 299 DFEITISRSLFEELNIEFFRKCMNLVTRVHTRSLITKQEIDHVIFVGGGGEIPKLKELISNYFGKTLYpKPLLPYE-VAFGVAFEGGILGG--FEQECL 394
                 *****************************************************************99736677777.8*************..8899** PP

                 EEEBESS-EEEEETTTEEEEEESTTCBSSEEEEEE.EEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEE CS
       HSP70 386 llDvtpLslgietlggvmtkliernttiptkksqv.fstaadnqtaveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvs 482
                 + D+t+  +  e++g++ t    +      k sq  +s    ++++++i++++g+r   ++   +++ ++ gi      ++++e  f+ d+nGil++ 
  EFC37913.1 395 IIDTTSRPITCEMEGNMLTIFPTEVSIPCIKVSQLlISDSIMERKTFQIKIFEGDRPESRELIGIATIDI-GID---LTSNRLETRFEFDVNGILSIM 488
                 ******99****999998877666655556667651566778899************9998777777776.676...567899************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       625  (0.0348597); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 3003.33
//
Query:       EFC37914.1  [L=725]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.4e-11   43.7  37.5    1.3e-09   38.1  23.0    4.7  5  Beta_helix  Right handed beta helix region
  ------ inclusion threshold ------
      0.016   15.7   0.2      0.041   14.4   0.2    1.7  1  Macin       Macin


Domain annotation for each model (and alignments):
>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.2   0.00061       5.5      78     112 ..      71     105 ..      16     128 .. 0.68
   2 !   20.3   6.5   4.5e-08    0.0004      55     137 ..     336     420 ..     314     431 .. 0.54
   3 !   38.1  23.0   1.5e-13   1.3e-09       2     158 .]     375     555 ..     374     558 .. 0.80
   4 !   15.9  28.6     1e-06    0.0091       2     134 ..     435     582 ..     434     643 .. 0.83
   5 ?   -4.8  10.1         2   1.8e+04     126     157 ..     612     642 ..     587     714 .. 0.62

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.00061
                 S--EEES-EEES-SS-SEE-TT-S--EEES-EEES CS
  Beta_helix  78 snnlienneitdnggsGiylnyssnntienNiidn 112
                 s++li+n +i+ n ++G y++++s  +++ + +++
  EFC37914.1  71 SQTLIKNVTIYVNIDDGRYFFNASTSIVKPSKFND 105
                 44555555555555555555555544444444433 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 4.5e-08
                 -S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-TT-S-.-EEES-EEESTT--SEE---TT.---EEES-EEES- CS
  Beta_helix  55 snntisnntisdnngggialfgasnnlienneitdnggsGiylnyssn.ntienNiidnnagsGividdss.snvtvtnNtitnn 137
                 ++  +sn +++ + g+g+ ++      i+ +++++ g+ Gi+++++++ ++i++N++++ ++ G++i+++s +++t  n  + +n
  EFC37914.1 336 NGQLFSNLKFEMCRGVGLVANTLTAIEISHCTFSNIGNRGISMTNCDDyCKINYNTFYEIGQGGLSISAGSrTTLTSWNALVMGN 420
                 4444455555555555555555555555555555555555555554444555555555555555555555554444444333333 PP

  == domain 3  score: 38.1 bits;  conditional E-value: 1.5e-13
                 SEEE-SS-E..EEESEEEES-SS-SEEE-SSS-............EEES-EEES......-SS-SEEE-TT-S-EEES-EEE---SEEE-TT.--S--E CS
  Beta_helix   2 gisingssn.vtiknntisnsggyGiylrgssn...........vvienneian......nsgsGiyilgssnntisnntisdnngggialf.gasnnl 81 
                 gis++++++ ++i+ nt++++g+ G+ +  +s+                n+i n       +   i+++g  ++t +nn+i+++   ++a++ g++n  
  EFC37914.1 375 GISMTNCDDyCKINYNTFYEIGQGGLSISAGSRttltswnalvmG----NTIFNysrigkTYRPAISVQG-VGITCRNNEIYNGD--HVAIMwGGNNHD 466
                 9*******************************9777777753330....555444666558888888887.***********888..555554555666 PP

                 EES-EEES-SS-.....SEE-TT...-S--EEES-EEESTT......--SEE---TT---EEES-EEES-SSEEEE-TT-SS--EEES-E. CS
  Beta_helix  82 ienneitdnggs.....Giylny...ssnntienNiidnna......gsGividdsssnvtvtnNtitnnkgaGiavvgsssnvtvrnNti 158
                 +++n+i++ ++s      iy      +  n i++N+i+n++      +  i++dd  s+vt+ +N+++++   G+ ++g++++++v +N++
  EFC37914.1 467 LSYNKIHNVCKSsqdssAIYSGRdwtQRGNLIRYNYIYNVKgmgdlgATCIYLDDMFSSVTMYGNILVDCY-RGL-LIGGGRDNVVFGNVF 555
                 78888888844444444888774588888*****************999*********************8.***.555555598888876 PP

  == domain 4  score: 15.9 bits;  conditional E-value: 1e-06
                 SEEE-SS-E.EEESEEEES-SS-SEEE-SSS-.EEES-EEES...-SS-SEEE-TT.....-S-EEES-EEE---......SEEE-TT.--S--EEES- CS
  Beta_helix   2 gisingssnvtiknntisnsggyGiylrgssnvvienneian...nsgsGiyilgs.....snntisnntisdnn......gggialf.gasnnlienn 85 
                 +is+ g++  t +nn+i+n  + +i+ +g+++  ++ n+i+n   +s++  +i+++      +n i+ n+i++ +      ++ i+l+   s +++++n
  EFC37914.1 435 AISVQGVGI-TCRNNEIYNGDHVAIMWGGNNH-DLSYNKIHNvckSSQDSSAIYSGrdwtqRGNLIRYNYIYNVKgmgdlgATCIYLDdMFSSVTMYGN 531
                 688888998.9********8888888888887.999999999999555555555554488888888888888888999999999999988999999999 PP

                 EEES-SS-SEE-TT-S--EEES-EEESTT--SEE---TT....---EEES-EE CS
  Beta_helix  86 eitdnggsGiylnyssnntienNiidnnagsGividdss....snvtvtnNti 134
                    d+ + G+ + +  +n++ +N++ nn+ ++i+ dd +    ++v+++ N +
  EFC37914.1 532 ILVDCYR-GLLIGGGRDNVVFGNVFVNNT-QAIYADDRGltwaNTVEINTNLL 582
                 9999988.999999999999999999999.99999999987777777777655 PP

  == domain 5  score: -4.8 bits;  conditional E-value: 2
                 --EEES-EEES-SSEEEE-TT-SS--EEES-E CS
  Beta_helix 126 nvtvtnNtitnnkgaGiavvgsssnvtvrnNt 157
                 +++vt N++++  +++i++++++   t +nNt
  EFC37914.1 612 GNNVTFNVFVGKTSNSIFNNFKKY-STYSNNT 642
                 333444444444444444444444.4444444 PP

>> Macin  Macin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.2   4.6e-06     0.041       5      34 ..     362     391 ..     359     398 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 4.6e-06
       Macin   5 dwsRCsestseltgilwrsCnsyCkvclka 34 
                 + s C+ s     gi +  C++yCk+ +++
  EFC37914.1 362 EISHCTFSNIGNRGISMTNCDDYCKINYNT 391
                 5789999999999*************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (725 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       535  (0.0298399); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.27s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 4516.37
//
Query:       EFC37915.1  [L=758]
Description: Sec23 protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.3e-61  205.5   0.0    2.7e-60  204.0   0.0    1.7  2  Sec23_trunk     Sec23/Sec24 trunk domain
      5e-28   97.7   0.2    1.2e-27   96.5   0.2    1.7  1  Sec23_BS        Sec23/Sec24 beta-sandwich domain
    3.6e-23   81.3   0.1    7.4e-23   80.3   0.1    1.6  1  Sec23_helical   Sec23/Sec24 helical domain
    3.9e-13   49.2   2.7    8.7e-13   48.1   2.7    1.7  1  zf-Sec23_Sec24  Sec23/Sec24 zinc finger
    1.2e-08   34.7   0.0    3.1e-08   33.4   0.0    1.7  1  Gelsolin        Gelsolin repeat


Domain annotation for each model (and alignments):
>> Sec23_trunk  Sec23/Sec24 trunk domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.54   1.9e+03     193     223 ..      81     111 ..      79     118 .. 0.86
   2 !  204.0   0.0   7.4e-64   2.7e-60       3     242 ..     121     385 ..     119     386 .. 0.97

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.54
                  EEEEEEECSS--SHHHHTHHHHTTT-EEEEE CS
  Sec23_trunk 193 svDlFlfsldyvdlaelkqlaeltgGqvvly 223
                  ++D+ +f+  y ++ e ++ ael +G + + 
   EFC37915.1  81 CMDVNMFPPSYSGITEAQHPAELHTGFTTIE 111
                  89999*****************999988765 PP

  == domain 2  score: 204.0 bits;  conditional E-value: 7.4e-64
                  --EEEEEEE-SHHHHHHTHHHHHHHHHHHHCTTSSTSTT-EEEEEEESSSEEEEETSTTS.......SSSEEEEECHTTSCC................ CS
  Sec23_trunk   3 ppvflFviDvsleaikegelkalkeslkqsLdllPeepralvglitfdsvvhffelksel.......rqpkelvvsdlqdvf................ 77 
                   pvfl ++D++l    e+e++++k+s++qsL+ +P  +++lvglit++ +v++fel++++       r++ke  v+++q+++                
   EFC37915.1 121 APVFLLLVDTCLP---EDEMRFMKDSILQSLNIIP--ENSLVGLITYGATVQVFELGFKEcskayvfRGDKETPVEQVQEQLglkmpsqpqqgqfgrl 213
                  69***********...*******************..************************************************************* PP

                  ......SSTSSSSSEETTTTHHHHHHHHHHHHH.HSTT-TTC-----HHHHHHHHHHHHCHCT..S-EEEEEEESS---SSTTTSS-SBTTS...CCT CS
  Sec23_trunk  78 ......lpladrlLvplseseavledlLeelpe.mfavtagkrperalgpalkaavellkave..tggkiivfvgslptvgaggklksrede...sll 163
                         p  +++L+pl ++ + l d++eel++ +++v++g+rp r++g+al++a +ll++++   g++i+ f+g+++t g g ++  ++ e    + 
   EFC37915.1 214 pnqpiiNPAISKFLCPLADCPQ-LMDIIEELQTdPWPVKSGRRPRRCTGVALSVATSLLESTFkgYGSRILNFIGGPCTFGDGEVVGLELIEqirLHN 310
                  *****99999**********75.789**********************************999999***********************988787788 PP

                  SSTTCHHCHSCSSSCHHHHHHHHHHHCTEEEEEEEECSS--SHHHHTHHHHTTT-EEEEETTTCCHHHHHHHHHHHHHH CS
  Sec23_trunk 164 didkekaklvkkadkfYkkLakecvkqgisvDlFlfsldyvdlaelkqlaeltgGqvvlydsFsaekdasklkqdlkrv 242
                  +  + ka ++kka++fYkk+a+++v++g+++D+F+++ld+++++e+k+++e tgG++vl+d F     + ++k+++ r 
   EFC37915.1 311 ELRSGKAPHFKKATEFYKKIAQRLVQNGHVLDIFAANLDQIGVLEMKSCCENTGGTMVLTDTFD----NPIFKESYMRF 385
                  89999**********************************************************9....89999998875 PP

>> Sec23_BS  Sec23/Sec24 beta-sandwich domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   96.5   0.2   3.3e-31   1.2e-27       1      94 [.     397     499 ..     397     501 .. 0.93

  Alignments for each domain:
  == domain 1  score: 96.5 bits;  conditional E-value: 3.3e-31
                 EEEEEEEEEE-TTEEEEEEESSSEEC....STBESSEESECSESEEEEEEEETT--EEEEEEE.....SSBTCTTSEEEEEEEEEEEETTSEEEEEEEE CS
    Sec23_BS   1 gfnatlevrtSkelkvsgliGncvsl....snvsekeiGeggtsewklcsldpdstlavyfdi.....deklksgkqayiQfatlYthssgerrlRVtt 90 
                 g+n+++e+++S+e+kv+g++G+++s+    +nvse+ iGeg t++wk+ +++p++tla+yfd+      +++++    ++Qf+t Y+h+sge+rlRVtt
  EFC37915.1 397 GLNGSVEIQCSNEIKVCGVLGPVTSMnrkaNNVSENIIGEGSTNAWKINAIHPSTTLAFYFDVvnqqnPTNMNTPAIRCFQFVTAYQHPSGEYRLRVTT 495
                 6899**********************999889*******************************998874468888999********************* PP

                 EEEE CS
    Sec23_BS  91 valp 94 
                  +l 
  EFC37915.1 496 QSLG 499
                 9875 PP

>> Sec23_helical  Sec23/Sec24 helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.3   0.1   2.1e-26   7.4e-23       1     102 [.     514     612 ..     514     613 .. 0.96

  Alignments for each domain:
  == domain 1  score: 80.3 bits;  conditional E-value: 2.1e-26
                    -HHHHHHHHHHHHHHHTTTS-HHHHHHHHHHHHHHHHHHHHHH-------------GGGTTHHHHHHHHHTSTTTS--TT--HHHHHHHHHHHHH- CS
  Sec23_helical   1 DqeavtvllakqaidkalesgladarealdtslvdllsayrkvgasgsspsqlqlpeslklLPlyilallKspafrggnsvpaDervfalslllsl 96 
                    Dqea+t+l+a++ + ka+++ l d+ ++ld+sl++l+s+++ ++ +  +p +l+l+ +++ +P+++++l++s+ +r +ns+p De+++++ ll+++
     EFC37915.1 514 DQEAATALVARLSVFKAETEYLFDVLRWLDKSLIKLVSKFGTYTPN--NPDSLILSPQFSVFPQFLYHLRRSQFLRVFNSSP-DETAWFRLLLNRE 606
                    9*******************************************76..999**********************8888*9999.************* PP

                    -HHHHH CS
  Sec23_helical  97 pvdqll 102
                     +++++
     EFC37915.1 607 TTTNSI 612
                    999986 PP

>> zf-Sec23_Sec24  Sec23/Sec24 zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.1   2.7   2.4e-16   8.7e-13       1      39 []      53      91 ..      53      91 .. 0.99

  Alignments for each domain:
  == domain 1  score: 48.1 bits;  conditional E-value: 2.4e-16
  zf-Sec23_Sec24  1 PirCrrCraylNpfckidfggkrwiCnfCnhknevppeY 39
                    P+ C++Cr +lNpf+++d++ k+w C++C   n +pp+Y
      EFC37915.1 53 PVVCKTCRGILNPFARVDYRIKQWSCPLCMDVNMFPPSY 91
                    99***********************************99 PP

>> Gelsolin  Gelsolin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.4   0.0   8.6e-12   3.1e-08       3      76 .]     626     714 ..     624     714 .. 0.97

  Alignments for each domain:
  == domain 1  score: 33.4 bits;  conditional E-value: 8.6e-12
                 EEEEEBSSSGGGEETTSEEEEEESS........EEEEEEHTT..SHHHHHHHHHHHHHHHH.....HCTTTTTSEEEEEETTHHHHHHH CS
    Gelsolin   3 vlpkvvklsssslesgdcyLLdngf........tiflWiGke..ssqeeknfaadlaaeld.....seerfplpeliredqgkeparFl 76 
                 + p +v+l+s s+ ++ ++LLd++f        t+  W+ ++  ++++++ fa +l+ + +      ++rfp+p++i +dqg  +arFl
  EFC37915.1 626 ESPHPVELDSNSVRPDVILLLDTFFtvlihygeTVTSWREAGyhHQPQYESFAKLLELPKNdakliIKDRFPYPRYIECDQGSGQARFL 714
                 5789***********************************99999********************************************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (758 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       426  (0.0237604); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 4475.88
//
Query:       EFC37916.1  [L=209]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-12   48.3   0.5    1.2e-12   48.3   0.5    1.6  2  WGG       Pre-rRNA-processing protein TSR2


Domain annotation for each model (and alignments):
>> WGG  Pre-rRNA-processing protein TSR2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.3   0.5   6.9e-17   1.2e-12       1      79 [.      32     111 ..      32     112 .. 0.94
   2 ?   -2.7   0.1      0.53   9.6e+03      26      44 ..     167     185 ..     147     194 .. 0.64

  Alignments for each domain:
  == domain 1  score: 48.3 bits;  conditional E-value: 6.9e-17
         WGG   1 FeegvalilhlWtaLklavengwggpdsadkrdwlagaivdlfk.akeeldqedvedvLlqvmedeFevnveDdSaeevA 79 
                 F ++v+ i+++WtaL+la ++++ g d++d  d++ ++i ++++ + ++l++++v +++ +v+e+++ +++ D+S + v+
  EFC37916.1  32 FCKAVNTIFSKWTALTLARQHSASGGDTDDLLDEFQNNIKEWISnDGDQLEVDEVVQYMNDVLEEDLGIDILDGSIKIVS 111
                 7899***************************************745567**************************99887 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.53
         WGG  26 pdsadkrdwlagaivdlfk 44 
                  ds+d   ++a++ +d ++
  EFC37916.1 167 VDSDDEDANMADHNHDHVH 185
                 4566666666666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1311  (0.0731218); expected 358.6 (0.02)
Passed bias filter:                      619  (0.0345251); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1324.75
//
Query:       EFC37917.1  [L=301]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.025   13.6   0.3      0.033   13.2   0.3    1.2  1  eIF-3_zeta  Eukaryotic translation initiation factor 3 subuni
       0.03   14.7   0.1      0.064   13.7   0.1    1.6  1  BRCT_2      BRCT domain, a BRCA1 C-terminus domain


Domain annotation for each model (and alignments):
>> eIF-3_zeta  Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.3   3.7e-06     0.033      30      95 ..      93     169 ..      86     262 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.7e-06
                 XXXXXXXXXXXXXXXXX.....XXXXXXXXXX.XXX.XXXXXXXXXXXXXXXXXXXX..XX.XXX............X CS
  eIF-3_zeta  30 pfsksdklgkvaDwtse.akekrekrraekygagsa.safayqheedessFslVdnkkakkkkkeak..........r 95 
                  +sk+  +g v+ +  + +++ r+k++++ky++++  +++++  +++++sF lVd+   ++  ++            +
  EFC37917.1  93 SYSKGVWIGDVSSFVLSpSESLRKKQKKSKYSDEEIrNMMNFIYQHNDKSFDLVDEDIFERMAET-PefegrsslglS 169
                 6899999********9977777776656799997776888999999**********977762222.224343322220 PP

>> BRCT_2  BRCT domain, a BRCA1 C-terminus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   7.1e-06     0.064       8      77 ..      25      98 ..      14     107 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 7.1e-06
      BRCT_2  8 lrFYin....daeps.psreklkklIeknGGevvetitsavyiviaesneeelaekrkrrvvspkyIkdCikkgk 77
                ++F+      + e s    +++ ++  + GGe+v++i++a++i i+++ +eela++    v+s k+I+++ +kg 
  EFC37917.1 25 FSFFFDikqdKLETScCRMDEIMTKALTLGGEIVDEIEDADFI-ISNQFDEELASSGIGMVLSEKFIEESYSKGV 98
                56666555432223334566777778889********988655.8888888888888899**********99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       770  (0.0429472); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 2075.29
//
Query:       EFC37918.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.7e-54  184.3   0.1    3.1e-54  183.5   0.0    1.4  2  GTP_EFTU     Elongation factor Tu GTP binding domain
    1.9e-39  134.4   0.1    4.4e-39  133.3   0.1    1.6  1  GTP_EFTU_D3  Elongation factor Tu C-terminal domain
    1.6e-13   50.9   0.1    5.9e-13   49.0   0.1    2.1  1  GTP_EFTU_D2  Elongation factor Tu domain 2
    7.6e-09   35.7   0.5    7.1e-06   26.1   0.0    2.8  3  MMR_HSR1     50S ribosome-binding GTPase
     0.0019   17.9   0.0     0.0038   16.9   0.0    1.4  1  NIF3         NIF3 (NGG1p interacting factor 3)
  ------ inclusion threshold ------
      0.011   15.9   1.0      0.078   13.2   0.1    2.4  2  Roc          Ras of Complex, Roc, domain of DAPkinase
      0.012   15.5   0.5      0.038   13.9   0.1    2.1  2  GTP_EFTU_D4  Elongation factor Tu domain 4
      0.013   14.9   0.1      0.037   13.4   0.1    1.9  1  SRPRB        Signal recognition particle receptor beta subuni
       0.16   11.6   1.6       0.23   11.0   0.1    1.9  2  Ras          Ras family


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  183.5   0.0   1.5e-57   3.1e-54       1     192 [.       5     229 ..       5     231 .. 0.89
   2 ?   -4.0   0.0       4.4   8.8e+03     127     140 ..     368     381 ..     360     392 .. 0.61

  Alignments for each domain:
  == domain 1  score: 183.5 bits;  conditional E-value: 1.5e-57
                 TCEEEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH.HHHST............HCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHH CS
    GTP_EFTU   1 krirnigiighvDhGKtTLtdrLlyktgaiskkgeka.eeerv............lDtlkeErergiTiksaaisleketkkylinliDtPGHvdFske 86 
                 k+++n+++ighvD+GK+T+t++L+yk+g i+k+  ++ e+e++            lD+lk+ErergiTi++a +++e  +kky +++iD+PGH+dF+k+
  EFC37918.1   5 KSHINVVVIGHVDAGKSTTTGHLIYKCGGIDKRVIEKfEKEAAemgkssfkyawvLDKLKAERERGITIDIALWKFE--SKKYVFTIIDAPGHRDFIKN 101
                 579******************************99996334336799999***************************..******************** PP

                 HHHHHHT-SEEEEEEETTTB.......STHHHHHHHHHHHHTTTE.EEEEEESCGST.....HHHHHHHHHHHHHHHHHHHHHHHHHHHTTT.TTEEEE CS
    GTP_EFTU  87 virglrvlDgavlvvdaveG.......vepqteevlrlalkegvp.iivfiNKmDrl.....kaelkeiveevkqklsrkeeklekygekge.kevpvv 171
                 +i+g++++D+a+lvvd+++G          qt+e++ la ++g++ +iv++NK D +     +++++ei++ev + l    ++l  ++e+g+ + v++v
  EFC37918.1 102 MITGTSQADVAILVVDSTNGgfeagfsKDGQTREHALLAYTLGIKqMIVCMNKFDDTtvkysDKRYEEIKSEVGRYL----KSLGFQTEEGKpNCVQFV 196
                 *********************************************************98888888888888888777....55555555555689**** PP

                 EEBTTTTBTHH............HHHHHHHHHS CS
    GTP_EFTU 172 fgSalkgegvk............tllealvell 192
                 ++S+++g+++              ll+al++l+
  EFC37918.1 197 PISGWTGDNMIeksdkmpwykgpCLLDALDNLV 229
                 ********9887777777887777888887765 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 4.4
                 EEEESCGST.HHHHH CS
    GTP_EFTU 127 vfiNKmDrl.kaelk 140
                 ++i K+Dr  + + +
  EFC37918.1 368 TIIEKIDRRsG-KTQ 381
                 56788888742.333 PP

>> GTP_EFTU_D3  Elongation factor Tu C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.3   0.1   2.2e-42   4.4e-39       4     111 ..     330     435 ..     327     436 .. 0.97

  Alignments for each domain:
  == domain 1  score: 133.3 bits;  conditional E-value: 2.2e-42
                  EECCEEEEEEESSS..SS-BSTT-EEEEESSS-EEEEEEEEEEECCSSTTSB-BSS-SSCCSTT-CEEEEEEECCEEEE--TTTHCCCCEEEEECTTC CS
  GTP_EFTU_D3   4 phtkfeAqvyilekerhtpitagYrpvlyirtadvtgkvveLlskldkktekvsekkpefvkpGdnvivevelikpialekgseypqlGrFaiReggr 101
                  ++ +f+Aqv+i+++  +++i +gY+pvl+++t+++++k++++++k+d++++k++e +pe +k+Gd++iv++ ++kp+++e + eyp+lGrFa+R++++
   EFC37918.1 330 EAVSFNAQVIIMNH--PGEIRNGYTPVLDCHTSHIACKFETIIEKIDRRSGKTQEANPEKIKKGDSAIVKIVPTKPMCVEGFVEYPPLGRFAVRDMKQ 425
                  6679**********..********************************************************************************** PP

                  EEEEEEEEEE CS
  GTP_EFTU_D3 102 TvaaGvvtei 111
                  Tva+Gv++++
   EFC37918.1 426 TVAVGVIKTV 435
                  *******988 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.0   0.1     3e-16   5.9e-13       1      72 [.     253     319 ..     253     321 .. 0.94

  Alignments for each domain:
  == domain 1  score: 49.0 bits;  conditional E-value: 3e-16
                  EEEEEEEEEESEEETTEEEEEEC.TCTTSEEEEEEEEEEEEETEEESEEETTSEEEEEEEESSCCSGSSTTCE CS
  GTP_EFTU_D2   1 GtvalgrvysGtlkkGdevrilg.ndtskkeivtrissletfhededeavaganaGvivaikgledaiivGdt 72 
                  Gtv  grv++G+lk+G+ v++ + +    +   t+++s+e++h  + ea +g+n+G++v++  + d i++G +
   EFC37918.1 253 GTVPVGRVETGKLKPGMMVHFAPgQA--AD---TEVKSVEMHHTSVPEAGPGDNVGFNVKGLSTTD-IKRGYV 319
                  99*******************99554..67...*********************************.****87 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.0    0.0035       6.9       1      20 [.       9      28 ..       9      42 .. 0.83
   2 !   26.1   0.0   3.6e-09   7.1e-06      10     114 .]      49     154 ..      46     154 .. 0.73
   3 ?   -2.3   0.0       2.3   4.7e+03      25      45 ..     372     392 ..     364     399 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0035
                EEEEEESTTSSHHHHHHHHH CS
    MMR_HSR1  1 evaivGrpNvGKStLinalt 20
                +v+++G+  +GKSt    l+
  EFC37918.1  9 NVVVIGHVDAGKSTTTGHLI 28
                599***********877765 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 3.6e-09
                 SSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.........TTCSHHHHHHHHH CS
    MMR_HSR1  10 vGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflaleeadlillvvdas.........eeklkpldeelee 99 
                  GKS++  a++ +k +++++ g T+di   +++ k+  ++++D pG  +    +  +++ +    +ad+++lvvd++         ++  +  ++ l +
  EFC37918.1  49 MGKSSFKYAWVLDKLKAERERGITIDIALWKFESKKYVFTIIDAPG--H----RDFIKNMITGTSQADVAILVVDSTnggfeagfsKD-GQTREHALLA 140
                 6********************************9999*********..4....23466666667789********7766664444311.1222233333 PP

                 HHHHTTSEEEEEEES CS
    MMR_HSR1 100 lleeakkplilvlnk 114
                 +     k++i+++nk
  EFC37918.1 141 YTL-GIKQMIVCMNK 154
                 321.34567777776 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 2.3
                 EESSSTTSSSSEEEEEEEETT CS
    MMR_HSR1  25 ivsdkpgtTrdinegrvklkg 45 
                 ++ ++ g+T++ n +++k+++
  EFC37918.1 372 KIDRRSGKTQEANPEKIKKGD 392
                 567788999999999998544 PP

>> NIF3  NIF3 (NGG1p interacting factor 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   1.9e-06    0.0038      15      62 ..     296     344 ..     287     356 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 1.9e-06
        NIF3  15 aeswDnvGlqvg.dpekevkkvllaldlteevleeAiekgadliithHP 62 
                 a   DnvG+ v+  +++++k+ ++a d+ ++   eA++ +a++ii  HP
  EFC37918.1 296 AGPGDNVGFNVKgLSTTDIKRGYVASDAKNDPSREAVSFNAQVIIMNHP 344
                 5568*******955556*******************************9 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1      0.29   5.8e+02       2      20 ..      10      28 ..       9      32 .. 0.84
   2 ?   13.2   0.1   3.9e-05     0.078       9     119 ..      48     156 ..      46     157 .. 0.74

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.29
                EEEESSTTSSHHHHHHCHC CS
         Roc  2 vvlvGdsgvGKtsllkrfv 20
                vv++G   +GK++   +++
  EFC37918.1 10 VVVIGHVDAGKSTTTGHLI 28
                89**********9877766 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.9e-05
                 TSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHH..H.....HCHHH.HH CS
         Roc   9 gvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrs..s.....enlke.Wl 99 
                 ++GK+s+   +v dk + +++  i +d++ ++++           kk+ + i D  G+ +f + +    ++a++ailv+ds++  +     ++ ++   
  EFC37918.1  48 EMGKSSFKYAWVLDKLKAERERGITIDIALWKFE----------SKKYVFTIIDAPGHRDFIKNMITGTSQADVAILVVDSTNggFeagfsKDGQTrEH 136
                 68**************************999862..........25688**************99999************7752212221122233033 PP

                 HHHHHHCSSS-EEEEEE-TT CS
         Roc 100 kelkkvagkspvilvgnkiD 119
                   l    g +++i+++nk D
  EFC37918.1 137 ALLAYTLGIKQMIVCMNKFD 156
                 33333455667888888887 PP

>> GTP_EFTU_D4  Elongation factor Tu domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       5.6   1.1e+04      67      86 .]       9      29 ..       6      29 .. 0.63
   2 ?   13.9   0.1   1.9e-05     0.038      21      72 ..     257     308 ..     252     319 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 5.6
                 EEEEESS-.TTTS--TT-EEE CS
  GTP_EFTU_D4 67 aisiegki.vGrqikegdily 86
                  + + g++ +G++   g  +y
   EFC37918.1  9 NVVVIGHVdAGKSTTTGHLIY 29
                 566667777777777776665 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 1.9e-05
                  EEEEEEEEEEETT-EEEETTE.EE.EEEEEEEETTEEESEEETT-EEEEEEES CS
  GTP_EFTU_D4  21 vGvevlgGvikpgvklikedGrev.GeilqiqdkgkkleeakaGqevaisieg 72 
                  vG +v +G++kpg+ +  + G+    e+++++ ++ ++ ea  G++v+  ++g
   EFC37918.1 257 VG-RVETGKLKPGMMVHFAPGQAAdTEVKSVEMHHTSVPEAGPGDNVGFNVKG 308
                  88.9*****************988358*********************99998 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   1.9e-05     0.037      45      86 ..      81     119 ..       5     176 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.9e-05
                 ..GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETT CS
       SRPRB  45 sekgskltliDfPGheklrqklleklkaksslkglvfvvDSt 86 
                 ++k+  +t+iD PGh  + +++++     s++   + vvDSt
  EFC37918.1  81 ESKKYVFTIIDAPGHRDFIKNMITG---TSQADVAILVVDST 119
                 668899************9999998...677788899****8 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1      0.62   1.2e+03       2      16 ..      10      24 ..       9      30 .. 0.85
   2 ?   11.0   0.1   0.00012      0.23       9      83 ..      48     120 ..      46     189 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.62
                EEEEESTTSSHHHHH CS
         Ras  2 lvlvGdsavGKtsll 16
                +v++G    GK++ +
  EFC37918.1 10 VVVIGHVDAGKSTTT 24
                89**********865 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00012
                 TSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTB CS
         Ras   9 avGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvydits 83 
                  +GK+s+ + +v dk k e e  i +d  ++  ++++k++ ++i D  G  +f +   +  ++a++++lv d t+
  EFC37918.1  48 EMGKSSFKYAWVLDKLKAERERGITID--IALWKFESKKYVFTIIDAPGHRDFIKNMITGTSQADVAILVVDSTN 120
                 58********************99666..556778899***************999999999******9998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       434  (0.0242066); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.55
# Mc/sec: 2444.01
//
Query:       EFC37919.1  [L=136]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-16   59.3   0.1    1.5e-15   57.2   0.0    1.9  2  Glutaredoxin     Glutaredoxin
    0.00016   21.9   0.0    0.00027   21.2   0.0    1.5  1  GST_N_2          Glutathione S-transferase, N-terminal domain
     0.0016   18.9   0.3     0.0062   17.0   0.1    2.0  2  Thioredoxin_2    Thioredoxin-like domain
     0.0041   17.5   0.0     0.0076   16.6   0.0    1.5  1  DUF836           Glutaredoxin-like domain (DUF836)
  ------ inclusion threshold ------
      0.011   15.8   0.0      0.022   14.8   0.0    1.6  1  Thioredoxin_3    Thioredoxin domain
      0.036   14.0   0.0      0.052   13.5   0.0    1.4  1  Thioredoxin      Thioredoxin
      0.053   13.3   0.0      0.062   13.1   0.0    1.3  1  Thioredoxin_9    Thioredoxin
      0.069   13.3   0.3        7.4    6.8   0.0    2.2  2  E3_UbLigase_RBR  E3 Ubiquitin Ligase RBR C-terminal domain
       0.11   12.9   0.0       0.15   12.5   0.0    1.3  1  GST_N_3          Glutathione S-transferase, N-terminal domain
       0.13   12.1   0.0       0.16   11.8   0.0    1.2  1  TraF             F plasmid transfer operon protein


Domain annotation for each model (and alignments):
>> Glutaredoxin  Glutaredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.2   0.0   8.1e-19   1.5e-15       1      60 []      40     103 ..      40     103 .. 0.97
   2 ?   -0.3   0.0      0.74   1.3e+03      17      27 ..     120     130 ..     117     133 .. 0.82

  Alignments for each domain:
  == domain 1  score: 57.2 bits;  conditional E-value: 8.1e-19
                   EEEEESTSSHHHHHHHHHHHHTTGG.EEEEEGCCSH...HHHHHHHHHHTSSSSSEEEETTEEE CS
  Glutaredoxin   1 vvlftkptCpyCkkakrlLkelgvk.feeidvdkde...eireelkelsgvrtvPqvfidgkhv 60 
                   v++f+k++CpyC++ + lLk+l ++ + ++++d+ +   ei++e+ ++sg rtvP ++i++++v
    EFC37919.1  40 VTVFSKSYCPYCQRLVGLLKKLSIEnVNVVQLDQLAdgfEIQQEVSSRSGSRTVPSLWIGQQYV 103
                   89*********************9999********999***********************997 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.74
                   HHHHHTTGGEE CS
  Glutaredoxin  17 rlLkelgvkfe 27 
                   +lL++++vkf 
    EFC37919.1 120 KLLEQNNVKFV 130
                   799****9995 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   1.5e-07   0.00027       1      55 [.      47     101 ..      47     121 .. 0.87

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 1.5e-07
                 S-HHHHHHHHHHHHCT--EEEEEE.H...-TTSHHHHHHHHCTTTSSSEEE-CTTE CS
     GST_N_2   1 aCPwahRvlialalkglediisvv.vlepkgfekseefprlnprgtVPvLwdkdgq 55 
                 +CP+++R   +l+ + +e++  v  ++  +gfe  +e++  +++ tVP Lw+ ++q
  EFC37919.1  47 YCPYCQRLVGLLKKLSIENVNVVQlDQLADGFEIQQEVSSRSGSRTVPSLWI-GQQ 101
                 5******************95443566789*********************9.445 PP

>> Thioredoxin_2  Thioredoxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.1   3.5e-06    0.0062       6      36 ..      37      69 ..      32     105 .. 0.79
   2 ?   -0.3   0.0      0.81   1.5e+03      16      33 ..     105     127 ..      96     134 .. 0.70

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3.5e-06
  Thioredoxin_2  6 kpvlvvftdpdCpyCkklkkelkel..ddvtvr 36
                    + ++vf+++ CpyC++l   lk+l  ++v+v 
     EFC37919.1 37 NHQVTVFSKSYCPYCQRLVGLLKKLsiENVNVV 69
                   6789**************999988866666655 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.81
  Thioredoxin_2  16 dCpyCkklkk..elkel...ddv 33 
                    +C   +kl+k  el++l   ++v
     EFC37919.1 105 GCDLAHKLHKtgELQKLleqNNV 127
                    58888999985556555544444 PP

>> DUF836  Glutaredoxin-like domain (DUF836)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   4.3e-06    0.0076       1      35 [.      39      72 ..      39     101 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 4.3e-06
                -EEEEE-TT-HHHHHHHHHHHHHCCCTTEEEEEEE CS
      DUF836  1 kltLyskpgChlCeqakekLkelkleegleleviD 35
                ++t +sk +C+ C+++  +Lk+l++e+  ++++ D
  EFC37919.1 39 QVTVFSKSYCPYCQRLVGLLKKLSIENV-NVVQLD 72
                589******************8876663.444444 PP

>> Thioredoxin_3  Thioredoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0   1.2e-05     0.022       2      56 ..      39      99 ..      38     123 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.2e-05
                   EEEEESSS.STTCHHHHHHHHHHCHCC.T.CEC.EEECCTTHHHH..HHCT-SSSSEEECT CS
  Thioredoxin_3  2 eikvlgpg.CakCpklekavkeaaaek.g.ika.evekvtdfeei..ekygVmsvPalvid 56
                   ++ v++++ C++C++l+ ++k++  e+ + +++ ++ +  ++++   ++ g ++vP+l i 
     EFC37919.1 39 QVTVFSKSyCPYCQRLVGLLKKLSIENvNvVQLdQLADGFEIQQEvsSRSGSRTVPSLWIG 99
                   578987777**************99998877776667776666555888999999999995 PP

>> Thioredoxin  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   2.9e-05     0.052      16      76 ..      37      96 ..      26     124 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.9e-05
                 TTSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTTTSEEEEEE..TTTSHHHHHHTT-SSSSEE CS
  Thioredoxin 16 kekklvlveFyApwCghCkalaPeleklaeelkdkvklakvd..vdenedlakkyevegiPtl 76
                 +   + +  F  ++C+ C++l + l+kl+ e  + v+l ++    + ++++ ++ + + +P l
   EFC37919.1 37 N---HQVTVFSKSYCPYCQRLVGLLKKLSIENVNVVQLDQLAdgFEIQQEVSSRSGSRTVPSL 96
                 3...44556999***************997765544444331123445556666666666666 PP

>> Thioredoxin_9  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   3.4e-05     0.062      40     101 ..      35      96 ..      18     125 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.4e-05
                    -S-EEEEEE--TT-HHHHHHHHHHHHHHHH-TTEEEEEE-HHHHH...HHTTTTTT.-SS--SSEE CS
  Thioredoxin_9  40 ekklkilvltedwCgDaavnvPvlakiaelnpnievkillrdenl...elmdqylt.ngaraiPtl 101
                     ++ ++ v+ + +C+ +++ v  l+k++ +n    v+++  d+     e+ ++ ++  g+r++P l
     EFC37919.1  35 INNHQVTVFSKSYCPYCQRLVGLLKKLSIEN----VNVVQLDQLAdgfEIQQEVSSrSGSRTVPSL 96 
                    4567999*********************998....3333333333000344444445677777765 PP

>> E3_UbLigase_RBR  E3 Ubiquitin Ligase RBR C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0    0.0041       7.4      42      88 ..      31      75 ..      21      80 .. 0.82
   2 ?    4.7   0.0     0.019        33       2      15 ..     117     130 ..     116     135 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0041
  E3_UbLigase_RBR 42 vkdeaCgkdvaegqaglCelHYkEyLvelinenkldPvvlfdedele 88
                     v ++  +++v+     +C   Y  +Lv+l+++ +++ v +++ d+l+
       EFC37919.1 31 VDENINNHQVTVFSKSYCP--YCQRLVGLLKKLSIENVNVVQLDQLA 75
                     5556667888888999996..99******************999886 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.019
  E3_UbLigase_RBR   2 rLqkLLkennikfd 15 
                      +LqkLL +nn+kf 
       EFC37919.1 117 ELQKLLEQNNVKFV 130
                      79*********994 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   8.5e-05      0.15       3      56 ..      44     102 ..      42     126 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8.5e-05
                 S-TTSHHHHHHHHHHHHHT--.EEEE---....TTTTHHHHHHH-TT--SSEEETTS-E CS
     GST_N_3   3 gfpaSpyarrvrlaLnekglp.vevvevt....pgehdeellaknplgkvPvLeddgea 56 
                 +  ++py++r   +L+ + ++ v+vv ++    ++e  +e++  ++ ++vP L ++++ 
  EFC37919.1  44 SKSYCPYCQRLVGLLKKLSIEnVNVVQLDqladGFEIQQEVSSRSGSRTVPSLWIGQQY 102
                 6779******9999999999668888886666566669***************877664 PP

>> TraF  F plasmid transfer operon protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   8.9e-05      0.16     119     170 ..      26      74 ..      19     103 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8.9e-05
        TraF 119 ekeaalkklakeygLlfFyrgkcpyceaqapilqafadkyglevraVsvdgr 170
                 e+++++ ++ +++   +F ++ cpyc+ ++  l+++  +    v +V++d+ 
  EFC37919.1  26 EIATFVDENINNHQVTVFSKSYCPYCQRLVGLLKKLSIE---NVNVVQLDQL 74 
                 5677788888999999***************99999765...4555666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       713  (0.039768); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 848.85
//
Query:       EFC37920.1  [L=597]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.4e-55  187.8   0.3    5.8e-55  186.5   0.1    1.8  2  Pkinase      Protein kinase domain
    1.4e-34  119.6   0.1    2.3e-34  118.9   0.1    1.3  1  Pkinase_Tyr  Protein tyrosine kinase
    0.00029   20.2   0.1      0.015   14.6   0.0    2.6  3  Kinase-like  Kinase-like
  ------ inclusion threshold ------
      0.024   14.6   0.0       0.21   11.5   0.0    2.1  2  APH          Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  186.5   0.1   1.3e-58   5.8e-55       1     263 [.     107     366 ..     107     367 .. 0.88
   2 ?   -2.9   0.0      0.79   3.5e+03     213     249 ..     526     561 ..     512     570 .. 0.68

  Alignments for each domain:
  == domain 1  score: 186.5 bits;  conditional E-value: 1.3e-58
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.....SSEEEEEEE--TTEBHHHHHH.... CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyveggeladlle.... 90 
                 ye+++ +G+G+fG+Vy +++++tgk  A+K++ k ++  +  +k+++Ei+i+k+l hpni+rl+++fe      +d +++v ey+e g++ad+le    
  EFC37920.1 107 YEVIKLVGRGTFGEVYHVKQTNTGKDLALKILIKPEKLRDL-EKIQNEIEIMKSLIHPNILRLLDTFEMkdeknTDCIVIVSEYCELGSIADYLEavvm 204
                 78999****************************99888766.59***********************997777677799***************99999 PP

                 .HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE..EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHH CS
     Pkinase  91 .rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGv 185
                  +k++++ + +  ++  ++e+++++ ++g+iHrD+Kp+N+Li+  +g   +K++DFGl+k l  ++ +++++g++ Y APE+ ++++y+++vDv+slGv
  EFC37920.1 205 nEKVNFPVWSITGWFVDMIESIKFCSARGVIHRDIKPSNMLIEaVDGRmvIKLADFGLSKALMAKQMASTMCGSPLYAAPEIYNRTGYTSAVDVYSLGV 303
                 777889999**********************************6666688************************************************* PP

                 HHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGG CS
     Pkinase 186 ilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpy 263
                 +++el +     +    +e     +++ ++++++          +s   +++k+l+ k+++ dpk R+++++l +hp 
  EFC37920.1 304 TILELACSYSHDE---FSE---IVVEEPHRVMEL---------FNSVKLPSMKELIMKMIHPDPKVRIGVNDLAEHPL 366
                 *****76543322...333...333332223333.........33444689*************************96 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.79
                 HHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSG CS
     Pkinase 213 lekilkilgetkeklpeaseiseeakdllkkllkkdp 249
                  +++lk+lg+ +++ +  +   e++k+++k+l+k+d 
  EFC37920.1 526 RTQVLKVLGDARMEDKVGD-KGEDIKQFMKELFKRDV 561
                 4556677766444444443.46888999999888875 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.9   0.1     5e-38   2.3e-34       3     256 ..     109     362 ..     107     364 .. 0.84

  Alignments for each domain:
  == domain 1  score: 118.9 bits;  conditional E-value: 5e-38
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE..SSSS....EEEEEE--TTEBHHHHHHH CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct..keep....llivteyvkgGdLlkfLrk 94 
                  + k +G+G+fG+V++ + +    ++  + a+K+l +  + ++ e++ +e++imk+l hpni++ll      + e+    ++iv ey++ G++ ++L++
   EFC37920.1 109 VIKLVGRGTFGEVYHVKQT----NTGKDLALKILIKPEKLRDLEKIQNEIEIMKSLIHPNILRLLDTFEmkD-EKntdcIVIVSEYCELGSIADYLEA 201
                  56889*********99888....89999******88888888************************999752.33467799***************98 PP

                  T...CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE...TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHH CS
  Pkinase_Tyr  95 k...ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse...nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsks 186
                      ek ++ + +++ + +++ + +++ +++ ++Hrd+   N+L++    ++v+k++DfGL+++++ ++    ++ +  p  + apE+ +++ +ts+ 
   EFC37920.1 202 VvmnEKVNFPVWSITGWFVDMIESIKFCSARGVIHRDIKPSNMLIEAvdgRMVIKLADFGLSKALMAKQMA--STMCGSP-LYAAPEIYNRTGYTSAV 296
                  766689999999*********************************9877788*************554444..4444455.59*************** PP

                  HHHHHHHHHHHHH.TTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 187 DvWsfGvllwEif.tlgespypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselv 256
                  Dv+s Gv++ E++ +++++ ++++  ee  + ++  + ++ p+     ++el++k  + dp+ R   ++l 
   EFC37920.1 297 DVYSLGVTILELAcSYSHDEFSEIVVEEPHRVMELFNSVKLPS-----MKELIMKMIHPDPKVRIGVNDLA 362
                  ***********96256777777777776666666555555555.....77888888888888887777665 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.014        64      18      59 ..     111     150 ..     106     164 .. 0.80
   2 !   14.6   0.0   3.3e-06     0.015     160     248 ..     229     313 ..     146     355 .. 0.78
   3 ?   -2.5   0.0      0.54   2.4e+03      22      72 ..     422     472 ..     418     489 .. 0.68

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.014
  Kinase-like  18 ellkkgdrsvvfevkdqetgeplavkvfllpseaskkdlerl 59 
                  +l+++g ++ v++vk  +tg++la+k+ + p++   +dle++
   EFC37920.1 111 KLVGRGTFGEVYHVKQTNTGKDLALKILIKPEKL--RDLEKI 150
                  67899999******************99888763..455555 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 3.3e-06
  Kinase-like 160 Lqakglvhgkftvdnlllde...kgglmlggftaLvragtkvvlseve..kgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwclkl 248
                    a+g++h ++++ n+l +    +  ++l +f+      +k  +s+++    +a pE+ ++         t +t ++d++ lG++i+ ++c + 
   EFC37920.1 229 CSARGVIHRDIKPSNMLIEAvdgRMVIKLADFGLSKALMAKQMASTMCgsPLYAAPEIYNR---------TGYTSAVDVYSLGVTILELACSYS 313
                  5689************986521144467889986555566666677776666899998877.........77899****************874 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.54
  Kinase-like  22 kgdrsvvfevkdqetgeplavkvfllpseaskkdlerlkeqelairllrgk 72 
                  ++ r+ ++  ++ +t+e + v   +++ ++s+ ++  l+e+   ++ l+ +
   EFC37920.1 422 NEHRQNILSSNELNTKEFFSVMMETVTIHNSHPKMAILHEAIVGLTVLKHQ 472
                  556667777777788888888888888888888888888887777776554 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0     0.095   4.3e+02       4      46 ..     112     159 ..     109     201 .. 0.82
   2 ?   11.5   0.0   4.7e-05      0.21     165     191 ..     231     255 ..     213     266 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.095
                 EE--.SSCEEEEEEETT.-.-EEEEE..E-TT.S-HHHHHHHHHHHHH CS
         APH   4 elsggasnrtylvttpa.g.ryvlrr..nppa.raaeeirrevallrl 46 
                  ++ g+   +y+v+ ++ g +++l++  +p++ r  e+i++e ++++ 
  EFC37920.1 112 LVGRGTFGEVYHVKQTNtGkDLALKIliKPEKlRDLEKIQNEIEIMKS 159
                 5666666789****999768****997655557999999999999865 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 4.7e-05
                 -EEEE-SS-SGGGEEEC..TTEEEEE- CS
         APH 165 ptvllHgDlhpgNllvdpddgrvtGvi 191
                 +++++H+D++p N+l+++ dgr+  vi
  EFC37920.1 231 ARGVIHRDIKPSNMLIEAVDGRM--VI 255
                 7899*************999999..88 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (597 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       760  (0.0423894); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 3696.73
//
Query:       EFC37921.1  [L=743]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00025   21.4   2.8       0.51   10.8   0.2    2.6  2  FtsX           FtsX-like permease family
     0.0034   17.0   0.0     0.0072   16.0   0.0    1.5  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
       0.15   12.4   3.9        9.8    6.6   0.2    2.6  2  Wzz            Chain length determinant protein


Domain annotation for each model (and alignments):
>> FtsX  FtsX-like permease family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.2   0.00014      0.83      58      93 ..      39      74 ..       9      77 .. 0.79
   2 !   10.8   0.2   8.5e-05      0.51      20      50 ..     319     349 ..     315     381 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00014
        FtsX 58 selkisidlitvliiivlllllallagllsiskilk 93
                + lk+ +++  +lii ++ll+++++++++++s  ++
  EFC37921.1 39 ILLKYLLSIRLILIITIILLVVFTAVSIWATSYSMN 74
                778999999999**************9999987765 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 8.5e-05
        FtsX  20 lllteillitlvalviGlglgllaaqllsdv 50 
                 ++++ ++++tl ++v+G+++g++++++++++
  EFC37921.1 319 IIIGVTVFVTLCGIVVGIVIGWVITNPFFTL 349
                 6889999*******************98876 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   1.2e-06    0.0072      10     156 ..     470     619 ..     465     646 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 1.2e-06
  Guanylate_cyc  10 tilFadIvgftalssahspievvklLnelyarfdelldekk.vykvktiGdaymvvsglpeekaah..aaklaelaLdmlealeevaveskeglkv 102
                    ++++  + + t+     +p  + +++ +  +++ ++++  +   ++k   + +++ +  +e+++ah  +++++++   ++   ++ ++e ++ l++
     EFC37921.1 470 AVIYLTLSNLTEETFDYDPGFMATIISKALTSISNICRTCRgDLQIKSH-NEFVIFFSNSEKNPAHtaLETCLKIRSMFVPFNDHLTKEGRPVLDI 564
                    5666666666666666667777777778888888888776634566665.45555555554444441156777777778888899999999***** PP

  Guanylate_cyc 103 rvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagkiqvseetyellk 156
                      G+ +G++v g +G ++++ + ++G     A  ++  +   +i + ++t     
     EFC37921.1 565 CMGVASGKMVNGNVGsKQTRYFALIGSVLERAKTLNEFSTFMNIPIVADTPCFIA 619
                    ***************445555689********99999999999999888866555 PP

>> Wzz  Chain length determinant protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.5    0.0024        14      16      56 ..      47      91 ..      38     131 .. 0.73
   2 ?    6.6   0.2    0.0016       9.8       7      51 ..     308     352 ..     305     390 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0024
                XXXXXXXXXXXXXXXXXXXXXXXX-EEEEEEEES--CHHH.....H CS
         Wzz 16 kklIilvtllfallaviyaflatpkYtataqilvpekkqv.....e 56
                ++lI+++t++ +++  ++++ at  Y+ + +++ ++ +q+     +
  EFC37921.1 47 IRLILIITIILLVVFTAVSIWAT-SYSMNETVALDQADQIvsnmkN 91
                67899999999999999998887.79***********997632222 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0016
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-EEEEEEEES-- CS
         Wzz   7 eLlsvLwkrkklIilvtllfallaviyaflatpkYtataqilvpe 51 
                 e+   + +++ +Ii vt++++l+++++ ++   + t     l+++
  EFC37921.1 308 EITAGIVQSSYIIIGVTVFVTLCGIVVGIVIGWVITNPFFTLQQD 352
                 67778899999***************9987665555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (743 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1190  (0.0663729); expected 358.6 (0.02)
Passed bias filter:                      612  (0.0341346); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 5041.99
//
Query:       EFC37922.1  [L=813]
Description: hypothetical protein NAEGRDRAFT_53403 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.034   14.0   0.1      0.081   12.8   0.1    1.6  1  F-box       F-box domain
      0.045   13.6   0.3       0.12   12.2   0.3    1.7  1  F-box-like  F-box-like
       0.11   11.9   0.0        0.2   11.1   0.0    1.3  1  IglC        Intracellular growth locus C protein


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   1.4e-05     0.081      10      37 ..     458     486 ..     429     495 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.4e-05
                 HHHHHHHTS-HHH.HHHHCTT-HHHHHHH CS
       F-box  10 vlrhILerLplsd.llalrrVSkgwrili 37 
                 v  +I+++ +  + l  lr+V+k w+++i
  EFC37922.1 458 VFFEIISWFDVESiLTILRCVCKAWYDWI 486
                 7889***********************98 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.3   2.1e-05      0.12       8      35 ..     458     486 ..     456     499 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.1e-05
  F-box-like   8 iLlqIFsyLppsdLlr.lalVCrrWrrva 35 
                 +  +I s+ + +++l  l++VC+ W++ +
  EFC37922.1 458 VFFEIISWFDVESILTiLRCVCKAWYDWI 486
                 678999******999978********987 PP

>> IglC  Intracellular growth locus C protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   3.3e-05       0.2      75     139 ..      10      77 ..       3      95 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 3.3e-05
                 EEEEE--SSS-EEEEEEEEEEEHHH...HHHHHHHHHHHHHCHGGG--EEE--B-S--EE-TTSSEE- CS
        IglC  75 rlsitpgsinptisitlgvliksnv...rtkieekvssilqasatdmkiklgnsnkkqeyktdeawgi 139
                 r  +    i  ti  t g     ++   r k  e+  si ++satd +i l ns  k+e + +e++  
  EFC37922.1  10 RKCVGSTNIIKTICDTTGKQFAIEMfleRPKQAERTKSITNSSATDPNITLANSYTKHEKHWNETFNK 77 
                 555555666667777776544433222388999**************************999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1214  (0.0677115); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.78u 0.35s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 4584.53
//
Query:       EFC37923.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.075   13.0   0.5       0.21   11.5   0.1    1.9  2  DUF1406   Protein of unknown function (DUF1406)


Domain annotation for each model (and alignments):
>> DUF1406  Protein of unknown function (DUF1406)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1      0.16     3e+03      22      48 ..      45      72 ..      39      78 .. 0.82
   2 ?   11.5   0.1   1.2e-05      0.21      34     103 ..     161     231 ..     142     238 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.16
     DUF1406 22 neYqPFnkl.sikleiytvenlvsytvd 48
                 +Y  F+k+ ++ l++ +  nl s t++
  EFC37923.1 45 GYYDEFDKMkNVVLNMRGSANLRSNTHL 72
                58999*9997899999999999998876 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 1.2e-05
     DUF1406  34 leiytvenl.vsytvdndkqselvisfkeltitvitesCdpvfdtvdvysvkDkkaielyttDeskkqres 103
                 +ei+    +  s+ +    ++++v  ++ +    ++++C  ++dtv+ +  ++ + i++ t++ s  q ++
  EFC37923.1 161 FEIENLGYIvLSFGHRKCMRTSVVFATSVFVSKFVSRDCPNGIDTVNTNEARNSTHIDGPTRNRSASQPQQ 231
                 56665555546777777788999***************************************999888655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       738  (0.0411624); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3602.92
//
Query:       EFC37924.1  [L=482]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.1   0.2       0.23   11.1   0.2    1.4  1  FTA2      Kinetochore Sim4 complex subunit FTA2
        3.7    7.4  32.7        8.8    6.1  27.2    2.2  2  SPX       SPX domain


Domain annotation for each model (and alignments):
>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   2.6e-05      0.23     115     190 ..      83     153 ..      75     156 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 2.6e-05
        FTA2 115 keqekklsrkfdaqelevqnsfakete.drsralgeedgkkrpiraIVKelellkeqeelevsqlpkllrdlkklhk 190
                 +++e+++++   ++     n+++++++  ++  + e ++ k+ ++aIVK+  +  ++e+ +v++l+  l d+ k+++
  EFC37924.1  83 SKEEREVAETYLEFA----NKIKGIADkLDQVQTTESNELKQQLLAIVKD--FTVKSEHPSVDILQSSLTDISKANE 153
                 444444444433333....333344424445667788999**********..8899999999999999999998875 PP

>> SPX  SPX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.2    0.0028        25     182     247 ..      92     158 ..      34     256 .. 0.64
   2 ?    6.1  27.2   0.00098       8.8      22     171 ..     310     471 ..     309     481 .. 0.33

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0028
         SPX 182 aekeFferLdseLnkvetFykakeeefterlesLrkqlealrprrikeaeer.ksdlyrwreifglk 247
                    eF +      +k+++ ++ + +e+ ++l ++ k++   +++ +  + ++  +d ++ +e + lk
  EFC37924.1  92 TYLEFANKIKGIADKLDQVQTTESNELKQQLLAIVKDFTVKSEHPSVDILQSsLTDISKANENQPLK 158
                 4555555555555555555555555555555555555554433222222222122222222222222 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.00098
         SPX  22 YkqLKKlIkkvqreleslgleaetlrellnrpedskkksse............................rtepstsaaadesgnsaadasssepkdeae 92 
                 Yk+LK  + k +++ +    ++++ +  +++ +++ k+ ++                             ++p++++++++sg++ +++s         
  EFC37924.1 310 YKALKTSLTKATKFVK---NRKQVMSAIRKTVSTAGKNWKKmgtvaklknanefrkaysgfktglsrktYSKPTQKRSNNQSGRNTRNNSG-------- 397
                 8888888888888777...233333333333333333333366688888888888777777666644332222222222222222222222........ PP

         SPX  93 slprrsplsrssrssssygglvssppsansssssddssesnpadssssssssesesssssspsllrrlfsesesreeks 171
                 ++++++++s+ss+s s  +g+ ss+ +++ s+ss+++s+s ++ ++ ss+ss  ++s+ss++s+ r+     +sr+++s
  EFC37924.1 398 RSSSQRRSSGSSSSKSRSSGSRSSSGRSSGSKSSGNRSGSRSS-GNRSSPSSGRSGSRSSKSSSGRSS----SSRSSSS 471
                 2222222222222222222222222222222222222222211.111111111111111111111111....1111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (482 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1794  (0.100061); expected 358.6 (0.02)
Passed bias filter:                      664  (0.037035); expected 358.6 (0.02)
Passed Vit filter:                       109  (0.00607954); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.89u 0.37s 00:00:01.26 Elapsed: 00:00:00.53
# Mc/sec: 2754.92
//
Query:       EFC37925.1  [L=146]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0009   18.9   2.1     0.0029   17.3   2.1    1.9  1  AT_hook      AT hook motif
  ------ inclusion threshold ------
       0.17   11.9   1.3       0.24   11.4   1.3    1.2  1  Phage_TAC_5  Phage XkdN-like tail assembly chaperone protein,


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   2.1   3.2e-07    0.0029       1      11 [.     118     128 ..     118     130 .. 0.89

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.2e-07
     AT_hook   1 kRkRGRPrKaa 11 
                 kR+RGRPrK++
  EFC37925.1 118 KRPRGRPRKHS 128
                 8********97 PP

>> Phage_TAC_5  Phage XkdN-like tail assembly chaperone protein, TAC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   1.3   2.7e-05      0.24      17      68 ..      84     132 ..      71     144 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 2.7e-05
                  E---TT-B-TTS-B--EEE----HHHHHHHHHHTB-------------B-HH CS
  Phage_TAC_5  17 vvaskrlkdekgkpvpfeikaiteeeieeirkectkkvkvkGkkvkkelDed 68 
                    +sk+   ++++ +pf ++++++ + ee rk++  k++ +G+ +k  +D++
   EFC37925.1  84 LQDSKK--RKHNESFPFVCHTVESMKEEEERKKAQPKRP-RGRPRKHSFDDK 132
                  334443..358899************************9.999977777764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       993  (0.0553851); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 816.19
//
Query:       EFC37926.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0017   18.0   2.7     0.0035   17.0   2.7    1.6  1  AT_hook   AT hook motif


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   2.7     2e-07    0.0035       1      11 [.     153     163 ..     153     165 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 2e-07
     AT_hook   1 kRkRGRPrKaa 11 
                 kR+RGRPrK++
  EFC37926.1 153 KRPRGRPRKNS 163
                 8********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       700  (0.0390429); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 1023.89
//
Query:       EFC37927.1  [L=2614]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.1e-59  199.6   0.0    1.6e-58  198.3   0.0    1.7  1  ketoacyl-synt    Beta-ketoacyl synthase, N-terminal domain
    9.6e-47  160.0   0.0    2.1e-46  158.9   0.0    1.5  1  Acyl_transf_1    Acyl transferase domain
    6.4e-42  143.5   0.0    3.1e-41  141.2   0.0    2.1  2  KR               KR domain
    2.7e-36  124.1   0.1    5.4e-36  123.2   0.1    1.5  1  Ketoacyl-synt_C  Beta-ketoacyl synthase, C-terminal domain
    7.5e-32  110.8   0.0    1.2e-31  110.1   0.0    1.3  1  PS-DH            Polyketide synthase dehydratase
    2.6e-18   66.5   0.0    7.6e-18   65.0   0.0    1.9  1  KAsynt_C_assoc   Ketoacyl-synthetase C-terminal extension
    1.4e-16   61.0   0.0    1.3e-15   58.0   0.0    2.7  2  Methyltransf_12  Methyltransferase domain
    1.5e-12   47.6   0.3    4.1e-12   46.3   0.3    1.8  1  PP-binding       Phosphopantetheine attachment site
      3e-11   43.4   0.0    1.1e-10   41.6   0.0    2.0  1  Methyltransf_31  Methyltransferase domain
    7.9e-08   32.9   0.0      6e-07   30.1   0.0    2.6  2  Methyltransf_25  Methyltransferase domain
    3.3e-07   30.4   0.0    7.3e-07   29.3   0.0    1.5  1  LCM              Leucine carboxyl methyltransferase
    1.8e-06   28.5   0.0    1.1e-05   26.0   0.0    2.3  2  Methyltransf_11  Methyltransferase domain
    4.3e-06   26.7   0.0    9.5e-06   25.5   0.0    1.5  1  Methyltransf_23  Methyltransferase domain
    7.9e-06   26.1   0.0    1.9e-05   24.9   0.0    1.6  1  Thioesterase     Thioesterase domain
    0.00052   19.5   0.0     0.0012   18.3   0.0    1.6  1  adh_short        short chain dehydrogenase
     0.0087   15.4   0.0       0.14   11.4   0.0    2.4  2  Hydrolase_4      Serine aminopeptidase, S33
  ------ inclusion threshold ------
      0.037   13.9   0.0       0.49   10.2   0.0    2.7  2  Lipase_3         Lipase (class 3)
        0.1   12.3   0.0       0.37   10.5   0.0    2.0  1  Methyltransf_16  Lysine methyltransferase
       0.41   10.7   2.7          8    6.5   0.1    3.6  3  MINDY_DUB        MINDY deubiquitinase


Domain annotation for each model (and alignments):
>> ketoacyl-synt  Beta-ketoacyl synthase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  198.3   0.0   1.7e-61   1.6e-58       4     243 ..      18     250 ..      15     252 .. 0.87

  Alignments for each domain:
  == domain 1  score: 198.3 bits;  conditional E-value: 1.7e-61
                    EEEEEEEEEBTTBSS.HHHHHHHHHTT---EEES-TTSSCGTTSBTSSTTEEE-BSS.EEE..S..TTEGGTTSTHHHHHHHCTS-HHHHHHHHHH CS
  ketoacyl-synt   4 vaivGmgarfPggnd.veefwelLlegrdaiselpadrwdadklydpparaagkiktklggfld..vddfdpeffgispreaeamdpqqrllleaa 96 
                      i+Gm+++fPg    ve+fw++Ll+g d  s++p++r + +++     +  +++++ ++ fl+   d+fd eff+is++ea +mdpq+rlll+++
     EFC37927.1  18 MGIIGMSCMFPGQAVdVESFWQVLLDGSDTSSTIPKER-QSSRF-----HNNKQTYN-RAHFLEkpLDEFDFEFFEISKKEACSMDPQHRLLLQQV 106
                    569********86544*******************655.33333.....34444454.444555599***************************** PP

                    HHHHHHHTS-HHTCTTGGEEEEEEESSTHHHHHHHHHHHTTGGGSCTTHHHHHSTTHHHHHHHHHHT--SSEEEEESGGGHHHHHHHHHHHHHHTT CS
  ketoacyl-synt  97 wealedagltpeeldgsrvgvfiGvgagdyaalaaldedgsevkaspkavgavlanviagrisyalglrGpsvtvdtACsSslvavhaavqslrsg 192
                    + aledag++ ee++g+++gvf+ v+++dy +++   + +   + ++  +++ +++  ++risy+++lrGps+t+dt Cs slva++ a++sl++ 
     EFC37927.1 107 YIALEDAGIKWEEIRGRNIGVFCSVMNQDYLTMKGWHDMQ-TYNSYS-LINS-SPANNSARISYHFDLRGPSFTLDTMCSGSLVALNCACESLQRD 199
                    ****************************993333332222.344455.7887.9****************************************** PP

                    S-SEEEEEEEE---SHHHHHHHHHTTBB-TTSGGGTTBTTB-SB-BB-EEE CS
  ketoacyl-synt 193 eadvalaGGvellltpeavagfsaagllspdgrckafdpkadGfvlGEGvG 243
                    e+++a++ Gv+l   p+++++ + +g+ +pdgrck+f+   dG+  +EGv+
     EFC37927.1 200 ECEMAIVAGVNLNYIPQEFVSQKLIGAAAPDGRCKTFSSHVDGYGKSEGVA 250
                    *************************************************97 PP

>> Acyl_transf_1  Acyl transferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.9   0.0   2.2e-49   2.1e-46       2     313 ..     540     888 ..     539     893 .. 0.76

  Alignments for each domain:
  == domain 1  score: 158.9 bits;  conditional E-value: 2.2e-49
                    EEE--TT---TTTTCCHHHC-HHHHHHHHHHHHHCCH....HHT--HHHHHHS--T..TGGGSHHHHHHHHHHHHHHHHHHHHHTT-TTSEEEE-T CS
  Acyl_transf_1   2 fvfsGqGsQwaGMGmeLlktskafaaviaradeafks....qygfsvldvlrnnpe..glldaiqfvqpaLaavqialaellkskGvrpaavvGHS 91 
                    fvfsGqG Qw +MG++Ll+t+++f a+++r d  +++    +  +s+ + l+   e    + +++ +qp ++avq + +e+lks+Gv+p +vvGHS
     EFC37927.1 540 FVFSGQGPQWFAMGRQLLETNNVFSATVERIDSEMQKimptNDKWSIVEELTTRTEkdTRIYSTNIAQPCIFAVQCGCYEVLKSYGVTPRIVVGHS 635
                    9*******************************988762222456**9998876655447899********************************** PP

                    THHHHHHHHCCSSSHHHHHHHHHHHHHHH.......HHHTS-EECCEECS.....HHHHHHH...TT.EEEEEEECCCCECCEEHHHHHHHHHHHH CS
  Acyl_transf_1  92 lGElAaavvagalsseeallavvlrsrlm.......mqlagpgdmaavel....aeeeeklr.cqddvvgavansprrvvisgsqealrelvervs 175
                    +GE+ aa+v g+l++eea+  ++ r rl        ++ +  g m a++l     ++ + +   ++ v  a +ns ++vv++g++  l++l  ++ 
     EFC37927.1 636 VGEVTAAYVHGCLTLEEAVFLIYHRARLQnkcatilKEFSKTGKMMAINLgldkLASILDILgFNNTVEIASVNSNSSVVVGGEEHVLKQLQLDLT 731
                    **************************9862222222566789*******9887633444444488999******************9998766555 PP

                    H....CC....CCEEECCCEECTTCCCCCCCCHHHHHHHH.CCCHHCH.......HTTB.EHCCCHHH.HHHCHHHHHHHHHHHCHCCHCCHHTTS CS
  Acyl_transf_1 176 k....eg...vgalvenvnvavhspqvdaiadalasalad.iaprkpk.......vaki.sstsldes.serelsaeywvanlrspvrfaeavlsa 254
                    k    e    v     + + a+h   ++ i+++l++ l + i  +k +       ++   s+++ ++s  ++ +  eyw +n+r  v+f +a+ ++
     EFC37927.1 732 KyvenEPnsrVNCVFLRNEAAFHTSHMEVIKKELLEVLSNrIS-KKERgtkpndnIQAVfSTVTGRKSnLQEMSTPEYWWNNVRGKVLFSQAMEEI 826
                    52211331112333334589*************9999987443.33221111111444313444444457777778*******************9 PP

                    ...SSECC-CCEECSSSSCCHCCCCCCCHH.GGG-TCCCCCCTEETTSS-HHHCHHHHHHHHH CS
  Acyl_transf_1 255 ...aetiplvfveispHslllaalektlks.aedvksatlvGklkrdltdflvtflyllakah 313
                        +   + ++eis H++l   +++   s   +  s  ++++l+r +++ +  +l+    ++
     EFC37927.1 827 fhtYKNSIKYVIEISSHPVLNGYIKDISSSsLGNEDSISVIPTLIRKKDE-QMSLLQVVSSLF 888
                    55445566789**********999998887567788999*******9999.666666665555 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.8   1.7e+03      79     137 ..     781     843 ..     740     853 .. 0.73
   2 !  141.2   0.0   3.3e-44   3.1e-41       1     178 [.    1847    2027 ..    1847    2029 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.8
                 S..S---EEEE---------TTT--HHHHHHHHTTTTHHHHHHHHHTTT..S--SEEEEEEEH CS
          KR  79 e..ppikGvihaAgvlrdklleemtaedleqvlapKvkGawnLhelled..esldffvlfSSi 137
                 +  ++i+ v+ +    + +l e  t e + + ++ Kv  ++ ++e+++   +s+++++ +SS 
  EFC37927.1 781 KpnDNIQAVFSTVTGRKSNLQEMSTPEYWWNNVRGKVLFSQAMEEIFHTykNSIKYVIEISSH 843
                 1346799999887777777777778999*****************999877889999999986 PP

  == domain 2  score: 141.2 bits;  conditional E-value: 3.3e-44
                  SEEEEETTTSHHHHHHHHHHHHHH.S-EEEEE-SS..--HHHHHHHHH..HHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE------- CS
          KR    1 gtylitGGlGgLGlelarwlaekg.arhlvllsRsaaadedskaliae..lealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvlrd 94  
                  g  +i GGlGg+Gl++++wl+ek   ++++ll+R+  +++++k  i++  l++ +a+++v+  D+ + + + ++++ei++++ pi+G++h+A+vl d
  EFC37927.1 1847 GCWVISGGLGGIGLKMCEWLVEKMkVSNIALLTRR-MPNKSEKLIIDKimLNNPNASIDVYITDICNYSTLYQTMQEIHQKF-PITGIVHSAMVLSD 1941
                  6789******************99899********.6677777788872245569************************988.************** PP

                  --TTT--HHHHHHHHTTTTHHHHHHHHHTTT..S--SEEEEEEEHHHHH--TT-HHHHHHHHHHHHHHHHHHHHHHTEEEEEE--B CS
          KR   95 klleemtaedleqvlapKvkGawnLhelled..esldffvlfSSiagllgsagqanYaaaNaflDalaeyrrsqglpavsinwglw 178 
                   + ++mt+e++e+v +pK+ G  nLh+++ +  ++l  f+++SS ++l+g++gq+nY ++N fl++l++yrrs gl++ s+ ++l+
  EFC37927.1 1942 CAANKMTKEKYETVARPKILGGFNLHQCSIKlnCNLSTFLMLSSFSSLVGAFGQSNYNSGNYFLESLCSYRRSCGLAGQSLGLSLI 2027
                  *****************************99889**********************************************999876 PP

>> Ketoacyl-synt_C  Beta-ketoacyl synthase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  123.2   0.1   5.8e-39   5.4e-36       2     117 ..     262     381 ..     261     382 .. 0.97

  Alignments for each domain:
  == domain 1  score: 123.2 bits;  conditional E-value: 5.8e-39
                      EEEEEEEEEE--.STSSSTSTTHHHHHHHHHHHHHHHT--GGGEEEEE-SS-SSHHHHHHHHHHHHHHHGGGGG...SCTSEEE-THHHH-B-G CS
  Ketoacyl-synt_C   2 avikgsavnsdg.ahnsltapngeaqaraiekalaeagvdpedvdyveahgtgtplgDpiElealkkvfgekar...kqplavgSvKsniGHle 91 
                      a i  + vn+dg ++ ++t p+ e+q +++e++++++g+ p+ v yve hgtgt++gD+iE++al + fg+++r    ++l++gSvKsniGH+e
       EFC37927.1 262 ALIMSTWVNHDGeRKSGITMPSLEGQVELLEQVYNKSGIPPQHVYYVESHGTGTTIGDKIETQALDSFFGRERRkhkLDKLPIGSVKSNIGHTE 355
                      7899999******************************************************************9888568************** PP

                      GGHHHHHHHHHHHHHHHTEE--BTT- CS
  Ketoacyl-synt_C  92 aAaGvaelikvvlalkhgvipptlnl 117
                      a +G+a++ik++l++kh++i++++++
       EFC37927.1 356 ATSGIASIIKAILMMKHRKIAKSIHC 381
                      ************************98 PP

>> PS-DH  Polyketide synthase dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  110.1   0.0   1.3e-34   1.2e-31       1     295 [.     943    1269 ..     943    1271 .. 0.82

  Alignments for each domain:
  == domain 1  score: 110.1 bits;  conditional E-value: 1.3e-34
                  BTTB..-EE--..-SS-EEEEEEE-S-...SS.TTTSEEETTEEB--TTHHHHHHHHHHHHTS---.-EEEE..EEEE----.B--SS-EEEEEEEE CS
       PS-DH    1 hpllG.srvrsa.sdkevvfrnrlrla...elpwLrDHrvdgkvvlPgagylemaleAarqltgeskavelr..dvsilkalvlpedepvevqlsle 90  
                  hpllG +++  + ++  +++++ ++++   ++ ++rDH+++++v +P  g++e+  +A+ +  ++  + elr  ++ + ++++l+ +ep+ vq++l+
  EFC37927.1  943 HPLLGnRKFNPMeNSPDIIYESLIDISsntDQMYIRDHKIENEVFFPYSGFVEISSAAILDNSSKN-VEELRlvNFKVVNPMILQ-QEPRIVQVHLN 1037
                  899984555555788889999999875222689****************************99988.666665599999***999.78999999999 PP

                  E-TTS-E....EEEEEEE-SS-TT......................EEEEEEEEEE-----.........--B--HHHHHH....HS-SEE....E- CS
       PS-DH   91 peedgadrawvefeifSregggee.....................wtehatGtvrlaegaa.........aaavdlealqa....rcaepaslrsvs 153 
                       a+    ef+ifS ++ +                       wt+ha G+ ++  ++          ++  + +        +++ +++++++ 
  EFC37927.1 1038 LY---AN----EFRIFSKKKVDLLsinyseiskdpsklsnklpcdWTLHAFGSFKTLDSSNsgdsinftnRELKAFD---IfrnfTENLDEKTQNIH 1124
                  99...45....8888888888766777888889999*******************9888888998886642222222...13334888888999*** PP

                  HHHHHHHHHHHSEEE-GGG--EEEEEEE....TTE.EEEEE---GGGSSTTTT-SB-HHHHHHHHHHG..GG----------EEEEEEEEEEE-S.. CS
       PS-DH  154 saefYerlaargleyGpsFqglralwrg....dge.alaelrlpeelaggesayvlhPallDaalQllaaalsaeaekadaaylPvaierlrvyr.. 243 
                  ++ +Y  l++ gl+yGp Fqgl+ + +     ++e   a+++ p +l+++e+ +  hPallD+++Q+++  ++     +d++ylP++ +++++ +  
  EFC37927.1 1125 KENIYFNLSKCGLNYGPCFQGLDLYSQVghdeTREvLMAQISHPKALENDERYCTWHPALLDSCFQMMICSMP-----EDTTYLPISTDEITIIPhr 1216
                  **********************9666655665333266888888999999987888**********9876664.....9***************988 PP

                  ...-BTS--EEEEEE.----SS-EEEEEEEE-SS-BEEEEEESEEEEE--XXX CS
       PS-DH  244 pssaageelwvharl.eeegarsivadltlvdedGrvvaeieglrlrrverea 295 
                  ++++++++++  +++ ++++ ++i++dl+++ e+ ++ ++++g+++ ++e ++
  EFC37927.1 1217 KPNNSKHTITRCVKYsKNAQTKEITCDLQVLGESNEPFISFNGFKVSPLETKE 1269
                  6666777777777778888889*************************998765 PP

>> KAsynt_C_assoc  Ketoacyl-synthetase C-terminal extension
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.0   0.0   8.1e-21   7.6e-18       2     108 ..     387     496 ..     387     500 .. 0.91

  Alignments for each domain:
  == domain 1  score: 65.0 bits;  conditional E-value: 8.1e-21
  KAsynt_C_assoc   2 npeipaleegrlkVvteptpwpggi....vgvNsfGfGGsnvHviLksnkkekrkeeskeeslprLlvlsgrteeaveallekleehlldaells 92 
                     np+i+ +e+ +++Vv ++ ++p +i    +g+NsfG+GG+n+H+iL+s ++ + +++++ ++  r+l+ls+++e +++ + ++++e +++ ++ +
      EFC37927.1 387 NPHIE-FEKKQIRVVMQEEEIPSNInpviIGINSFGMGGTNAHCILQSVEQLEHQRKNSISEGIRILPLSAKSEYSLKMMSSSVAEFSAQCNQDD 480
                     9****.********************************************99999999999**************************99999988 PP

  KAsynt_C_assoc  93 llneilseeisrlpyR 108
                     ll +  +++ +  +yR
      EFC37927.1 481 LLFNYCEKKSQFRDYR 496
                     8877777766656666 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.0   0.0   1.3e-18   1.3e-15       1      99 []    1464    1570 ..    1464    1570 .. 0.93
   2 ?   -1.3   0.0         4   3.8e+03       3      30 ..    2560    2585 ..    2558    2601 .. 0.82

  Alignments for each domain:
  == domain 1  score: 58.0 bits;  conditional E-value: 1.3e-18
  Methyltransf_12    1 LeiGcGtGsllrallekl......pdieytgvDispsaiedakeklakrennnnnnvelealdlldldgg......ssfDlvvasnvlhhlk 80  
                       LeiG+G G +++ +l+ l      +d++y+++Disp ++++akek+a+ e     ++e+  ld+++ + +      +sfDlv+a+nv+h+++
       EFC37927.1 1464 LEIGAGLGGTTKQILPILdslrdyIDVKYVFTDISPLFLVKAKEKFAQFEY----FMEFSLLDIEKPFVSsefiekDSFDLVIAANVVHATQ 1551
                       8*************************************************8....77777777765555577899***************** PP

  Methyltransf_12   81 direvldnirklLkpgGrl 99  
                       d+++v++ i +lL+ +G+l
       EFC37927.1 1552 DLKSVFSLISSLLVSNGQL 1570
                       *****************97 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 4
  Methyltransf_12    3 iGcGtGsllralleklpdieytgvDisp 30  
                       +GcG  s  ++l     + +++++Di+ 
       EFC37927.1 2560 LGCGLCSRYERLFGM--NEKVHWIDIDL 2585
                       899999999999999..99******984 PP

>> PP-binding  Phosphopantetheine attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.3   0.3   4.4e-15   4.1e-12       2      67 .]    2114    2179 ..    2113    2179 .. 0.97

  Alignments for each domain:
  == domain 1  score: 46.3 bits;  conditional E-value: 4.4e-15
  PP-binding    2 klrelvaevlgvpleeidpdtdlfdlGlDSllavellaaleeefgveiplsdlfehptlaelaayl 67  
                  k+ ++v++v+g++++ei ++ +l d+GlDSl++ve+ + l++ef  +i++s+l+   +++ l++++
  EFC37927.1 2114 KVSDIVSKVFGMDESEIQLEKPLVDYGLDSLMSVEIRNILSREFSSSITVSTLLSGVSVSTLVEMI 2179
                  7899**********************************************************9987 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.6   0.0   1.1e-13   1.1e-10       2     113 ..    1458    1576 ..    1457    1643 .. 0.87

  Alignments for each domain:
  == domain 1  score: 41.6 bits;  conditional E-value: 1.1e-13
  Methyltransf_31    2 dkglrvlDlGCGtGeltfelae.....elgpkaevvGiDiseeaielArenaqklgldnveFeqgdiee..lekl.ledekfDlilsnevln 85  
                       +k+lr+l++G+G G  t+++       + + + ++v  Dis+  + +A+e+ ++ ++  +eF+  die+   ++  +e+++fDl+++ +v++
       EFC37927.1 1458 KKTLRILEIGAGLGGTTKQILPildslRDYIDVKYVFTDISPLFLVKAKEKFAQFEY-FMEFSLLDIEKpfVSSEfIEKDSFDLVIAANVVH 1548
                       7899*****************9999554444999*******************9999.8***********555568888************* PP

  Methyltransf_31   86 aladpdkileeiervlkpggilliedpr 113 
                       a+ d+++++  i+++l ++g l++ + +
       EFC37927.1 1549 ATQDLKSVFSLISSLLVSNGQLVLVESD 1576
                       ***********************99988 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.0   6.3e-10     6e-07       1      97 []    1463    1568 ..    1463    1568 .. 0.84
   2 ?   -2.1   0.0       6.7   6.4e+03       1      37 [.    2557    2592 ..    2557    2603 .. 0.68

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 6.3e-10
                       EEEET-TTSHHHHHHHCTS....T..SSEEEEEESSHHHHHHHHHHHHHTTTTEEEEESBCCG..BS..S.STTTEEEEEEESTGGGSSHHH CS
  Methyltransf_25    1 vLdlGcGtGrltlalakrl....g..kakvtgvDiseemleaareraeeeglnvefvqgdaed..lp..f.edgsfDlvvssgalhhlsded 81  
                       +L++G+G G +t++++  l       + k++ +Dis+ +l +a+e++++ ++ +ef   d+e+  ++  f e++sfDlv++++++h +  +d
       EFC37927.1 1463 ILEIGAGLGGTTKQILPILdslrDyiDVKYVFTDISPLFLVKAKEKFAQFEYFMEFSLLDIEKpfVSseFiEKDSFDLVIAANVVHAT--QD 1552
                       8***********998888665442579********************99999*********9965223346889*******8777764..69 PP

                       HHHHHHHHHHHEEEEE CS
  Methyltransf_25   82 lekalkeiarvLkpgG 97  
                       l+ +++ i+++L  +G
       EFC37927.1 1553 LKSVFSLISSLLVSNG 1568
                       9********9998877 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 6.7
                       EEEET-TTSHHHHHHHCTSTSSEEEEEESS.HHHHHHH CS
  Methyltransf_25    1 vLdlGcGtGrltlalakrlgkakvtgvDis.eemleaa 37  
                       ++ lGcG     ++l     ++kv+ +Di+ ++ +e  
       EFC37927.1 2557 IVNLGCGLCSRYERLFGM--NEKVHWIDIDlPNVIELR 2592
                       678999988777777655..599999999834444444 PP

>> LCM  Leucine carboxyl methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.0   7.7e-10   7.3e-07       6     126 ..    2487    2596 ..    2484    2603 .. 0.75

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 7.7e-10
                  HHHHHHHHHHHHTSSHTCCCCCCCHHHHHHHHCHCCCHCHHCHGCHCCCCT--HHHHHHHHHHHHHHHHHHHHHH.HCTT....ESEEEEET-TT-- CS
         LCM    6 aaralesrraadglidDplaeslvsaaglellerkadkelekekeeekkekkapelnrgiavRtrffddllkaal.saag....irqvViLGAGlDt 97  
                  + rales ++ dg+++Dp+a  + ++   +l        ++         ++ +  +  i+ Rt + d   ++++ + +        +V+LG+Gl +
  EFC37927.1 2487 VSRALESLES-DGILYDPIAVKIFQNLPEDL-------SVDV--------QNDRITRTNIVGRTIVLDRKSQEFVsK-SLakheKVMIVNLGCGLCS 2566
                  5799999987.9***********99997765.......2222........234555556667777766655555522.1123234489********* PP

                  HHHHHHHTT.TEEEEEEE-HHHHHHHHHHH CS
         LCM   98 rayRlpwla.glkvfEvDqpevlefKretl 126 
                  r  Rl  ++ +++++++D p+v+e++r+ +
  EFC37927.1 2567 RYERLFGMNeKVHWIDIDLPNVIELRRQWI 2596
                  *************************99876 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.0   0.0   1.1e-08   1.1e-05       1      95 [.    1464    1571 ..    1464    1572 .. 0.87
   2 ?   -1.4   0.0       4.2   3.9e+03      20      68 ..    2338    2381 ..    2327    2385 .. 0.82

  Alignments for each domain:
  == domain 1  score: 26.0 bits;  conditional E-value: 1.1e-08
                       EEET-TTSHHHHHHH......HTT..SEEEEEES-HHHHHHHHHHCCHHT-EEEETTEECCC....TS.S-TT-EEEEEEES-CCC-CCHHH CS
  Methyltransf_11    1 LdvGcGtGrlaeala......krg..arvvgvDlskemlklakekaseeglkvefvvadaek....lp.fednsfDlvvssevlhhvedpek 79  
                       L++G+G G  ++++       + +   ++v +D+s+ +l  akek  + +  +ef   d+ek       +e++sfDlv++ +v+h  +d+++
       EFC37927.1 1464 LEIGAGLGGTTKQILpildslRDYidVKYVFTDISPLFLVKAKEKFAQFEYFMEFSLLDIEKpfvsSEfIEKDSFDLVIAANVVHATQDLKS 1555
                       79999999999999989988855579*************999999999888899*999**9854323334557******************* PP

                       HHHHHHHHEEEEEEEE CS
  Methyltransf_11   80 alkeiaRvLkpgGllv 95  
                       +++ i  +L  +G lv
       EFC37927.1 1556 VFSLISSLLVSNGQLV 1571
                       *************998 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 4.2
                       EEEEEES-HHHHHHHHHHCCHHT-EEEETTEECCCTSS-TT-EEEEEEE CS
  Methyltransf_11   20 rvvgvDlskemlklakekaseeglkvefvvadaeklpfednsfDlvvss 68  
                        +v +Dl +++++  ++  ++++        d+ ++p+ +++fD+ + +
       EFC37927.1 2338 GIVDLDLFPNVTEGIENLDEKAK-----KIRDLMEIPLFKHQFDFLLKY 2381
                       57889999999999988888887.....7899999**9999***98765 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.5   0.0     1e-08   9.5e-06       7     132 ..    1442    1584 ..    1433    1622 .. 0.66

  Alignments for each domain:
  == domain 1  score: 25.5 bits;  conditional E-value: 1e-08
  Methyltransf_23    7 eelsdklerllpk..lraggrvLdiGcGtGil.......levlrengf.svtgvDlspeaveiaekakkaqkdqfdeqeaae.......... 78  
                       + l d+++   pk  +++  r+L+iG+G G +       l++lr++   ++++ D+sp    +a k k+aq++        +          
       EFC37927.1 1442 KPLFDFILNSIPKngKKKTLRILEIGAGLGGTtkqilpiLDSLRDYIDvKYVFTDISPLFLVKA-KEKFAQFEY-------Fmefslldiek 1525
                       45556666666662345555**********7645554444444555335********9644444.333333333.......13334555666 PP

  Methyltransf_23   79 ........pqgkfdlIvlrevlehvpdppellrqiatllkpgGylllseplaslkedrllld 132 
                               ++++fdl+++ +v +  +d+ ++++ i +ll  +G l+l e++   +    +l+
       EFC37927.1 1526 pfvssefiEKDSFDLVIAANVVHATQDLKSVFSLISSLLVSNGQLVLVESD---PLGAQFLH 1584
                       77777777888*************************************985...34444444 PP

>> Thioesterase  Thioesterase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.0     2e-08   1.9e-05       3     105 ..    2221    2315 ..    2219    2387 .. 0.88

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 2e-08
                    EEEE--TTCCSGGGHHHH.HHCTTCEEEEEEECSTTSTSHHHCTTCHHHHHHHHHHHHHHH-SSSSEEEEEETHHHHHHHHHHHHHHHC.T-SEE CS
  Thioesterase    3 LflfppagGsasvfrsla.sklsdpvvevlavqlpgrerdepplesieelaaeyaealrqiqpegPyalfGhSlGgllAfevArqLesq.Glavk 95  
                    L +fp  gG ++ fr l  +++s +   v+++ + +       ++++++   ++ +++ q      +++ GhS+G+l+A e++r  + +   ++ 
    EFC37927.1 2221 LLCFPALGGTVHDFRDLNlEEFSIY---VINLDYLRN------NSDWTAHFMQVWDCVHQLFNSNTVTIYGHSMGALVALEFTRFIQFKfNKKPV 2306
                    89***************84556666...999999999......69******************************************99999999 PP

                    EEEEESCCCC CS
  Thioesterase   96 slflidssap 105 
                     l++++  ap
    EFC37927.1 2307 KLIVSGN-AP 2315
                    9999994.33 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   1.3e-06    0.0012       4     154 ..    1850    2003 ..    1848    2013 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 1.3e-06
                  EEESTTSHHHHHHHHHHHHTT..-EEEE.EESCHHHHHHHHHH.HHHT..TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGG CS
   adh_short    4 lvtGassGIGraiakelakeG..akvvv.vdrseekleevake.lkee..gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfs 94  
                  ++ G+ +GIG+++++ l+++    ++++ + r ++k e+++   +  +  +a++ ++ +D+ +++ + ++++++ +k+ ++  +v+ A +  +++++
  EFC37927.1 1850 VISGGLGGIGLKMCEWLVEKMkvSNIALlTRRMPNKSEKLIIDkIMLNnpNASIDVYITDICNYSTLYQTMQEIHQKF-PITGIVHSAMVLSDCAAN 1945
                  789**************987311234445889999999986541332347999*********************9998.79**************** PP

                  GCSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-TTBHHHHHHHH CS
   adh_short   95 elseeewervievNltgvflltravlpamlkqssGrIvnvsSvagkvpvagvaaYsAsKa 154 
                  ++++e++e v    + g f+l +  ++   + +  +    sS  ++v+ +g++ Y +   
  EFC37927.1 1946 KMTKEKYETVARPKILGGFNLHQCSIKL--NCNLSTFLMLSSFSSLVGAFGQSNYNSGNY 2003
                  *********************9999988..678888899999999999999999987655 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.28   2.6e+02      72      92 ..     623     643 ..     615     654 .. 0.82
   2 !   11.4   0.0   0.00014      0.14      55      94 ..    2255    2294 ..    2250    2322 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.28
  Hydrolase_4  72 ehpelplfllGhSmGGliall 92 
                   ++ +p++++GhS+G ++a+ 
   EFC37927.1 623 SYGVTPRIVVGHSVGEVTAAY 643
                  56678**********888875 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00014
  Hydrolase_4   55 fddyvdDlaafvekvkeehpelplfllGhSmGGliallyl 94  
                    +d+++ + ++++ v +  +   ++++GhSmG+l+al+++
   EFC37927.1 2255 NSDWTAHFMQVWDCVHQLFNSNTVTIYGHSMGALVALEFT 2294
                   5677777788899999999999***************987 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       1.2   1.1e+03      58      80 ..     620     642 ..     603     651 .. 0.81
   2 ?   10.2   0.0   0.00052      0.49      48     104 ..    2262    2313 ..    2216    2338 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.2
                 HHHHTT-EEEEEEEETHHHHHHH CS
    Lipase_3  58 llekypeysivvtGHSLGgalAl 80 
                 +l++y  +  +v+GHS G  +A+
  EFC37927.1 620 VLKSYGVTPRIVVGHSVGEVTAA 642
                 6667776666789*****87775 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00052
                  HHHHHHHHHHHHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS---EEEEEES- CS
    Lipase_3   48 reqvlkelkrllekypeysivvtGHSLGgalAlLaaldlvengenekkkvtvvtfGq 104 
                   +qv +++++l++++    +++ GHS+G+ +Al ++  ++ + +  kk+v++++ G+
  EFC37927.1 2262 FMQVWDCVHQLFNSNT---VTIYGHSMGALVALEFTRFIQFKFN--KKPVKLIVSGN 2313
                  5789999999999999...*************999988888874..47888777665 PP

>> Methyltransf_16  Lysine methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0    0.0004      0.37      43     155 ..    1456    1573 ..    1430    1586 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.0004
  Methyltransf_16   43 nelsklsvlELGsGtGlvGlavael......lpeakviltDleellellkknielnknalkskvkvevLdWgeel.eedllekeevDlilaa 127 
                        + ++l++lE+G+G G +   +         + ++k + tD++ l  l+k   +   ++ +  ++++ Ld +++   ++++ek ++Dl++aa
       EFC37927.1 1456 GKKKTLRILEIGAGLGGTTKQILPIldslrdYIDVKYVFTDISPLF-LVKAKEKF--AQFEYFMEFSLLDIEKPFvSSEFIEKDSFDLVIAA 1544
                       4667889999999987443222222344455678888999999865.34444344..3488899999999988852678999********** PP

  Methyltransf_16  128 DcvYledslelLvkvLkellkkesk.vlv 155 
                        +v   + l+   ++++ ll ++++ vlv
       EFC37927.1 1545 NVVHATQDLKSVFSLISSLLVSNGQlVLV 1573
                       ********************999995554 PP

>> MINDY_DUB  MINDY deubiquitinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.1    0.0085         8       1      52 [.     742     793 ..     742     805 .. 0.80
   2 ?    1.7   0.0      0.26   2.5e+02      29      70 ..    1444    1500 ..    1393    1524 .. 0.67
   3 ?   -1.3   0.1       2.3   2.2e+03      15      45 ..    2165    2200 ..    2152    2229 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0085
   MINDY_DUB   1 vNvLlLsgkiellpedreevsleeLlelladilldnnp.lnqeenlsellelL 52 
                 vN+ +L+++  + ++++ ev  +eLle+l++ + ++++ ++ ++n++++++++
  EFC37927.1 742 VNCVFLRNEAAF-HTSHMEVIKKELLEVLSNRISKKERgTKPNDNIQAVFSTV 793
                 79**********.588889999***********99999444555676666655 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.26
   MINDY_DUB   29 ladilldnnplnqeen..............lsellelLpklqtgldvnprFdgid.s 70  
                  l+d +l++ p+n +++              ++++l +L +l+  +dv+  F++i+  
  EFC37927.1 1444 LFDFILNSIPKNGKKKtlrileigaglggtTKQILPILDSLRDYIDVKYVFTDISpL 1500
                  455555555544444467777888888887999******************666532 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 2.3
   MINDY_DUB   15 edreevsleeLlelladilldnnplnqeen.....l 45  
                  +  + vs++ L+e++++   ++n++ ++++     +
  EFC37927.1 2165 TLLSGVSVSTLVEMISNSGKSSNQQLTQQSnspnqT 2200
                  55667999999***9999988888444443233331 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2614 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       819  (0.0456802); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 1.33u 0.38s 00:00:01.71 Elapsed: 00:00:00.58
# Mc/sec: 13679.84
//
Query:       EFC37928.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-17   64.4   0.3    2.4e-17   63.4   0.3    1.5  1  TLD              TLD
    0.00048   20.4   0.0    0.00089   19.6   0.0    1.5  1  BTB_2            BTB/POZ domain
     0.0019   18.3   0.0     0.0054   16.8   0.0    1.7  1  BTB_3            BTB/POZ domain
  ------ inclusion threshold ------
      0.016   15.1  11.2      0.016   15.1  11.2    2.5  2  zf-C3HC4_2       Zinc finger, C3HC4 type (RING finger)
      0.065   13.6   0.9      0.065   13.6   0.9    2.1  2  Lar_restr_allev  Restriction alleviation protein Lar
       0.07   13.2   8.4       0.22   11.6   8.4    1.9  1  zf-C3H2C3        Zinc-finger
      0.096   13.4   1.2      0.096   13.4   1.2    2.6  2  zf-TRAF          TRAF-type zinc finger
        0.1   13.0   3.7       0.26   11.7   3.7    1.6  1  E6               Early Protein (E6)
       0.64    9.9  14.5      0.042   13.7   6.7    2.4  2  zf-C3HC4_3       Zinc finger, C3HC4 type (RING finger)
       0.73    9.3   6.2       0.28   10.7   0.6    2.3  2  Mu-like_Com      Mu-like prophage protein Com
        1.5    8.5   8.1       0.17   11.5   2.6    2.3  2  zf_C2H2_13       Zinc finger domain
        1.6    8.8  14.9       0.27   11.3   0.8    3.1  2  zf-C2HC5         Putative zinc finger motif, C2HC5-type
          5    7.5  16.4       0.79   10.1   8.7    2.8  2  zf-RING_2        Ring finger domain
        5.4    7.2  13.2       0.66   10.1   6.2    2.6  2  DUF1272          Protein of unknown function (DUF1272)
        6.8    6.9  13.3        1.1    9.5   7.1    2.9  2  zf-C3HC4_4       zinc finger of C3HC4-type, RING


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.4   0.3     2e-20   2.4e-17       1     138 [.     253     404 ..     253     405 .. 0.80

  Alignments for each domain:
  == domain 1  score: 63.4 bits;  conditional E-value: 2e-20
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpw...kssnkkfygdsesflfsl.spkfkvykstgkn...kaylntssdglgfGgg 92 
                 lly+ s+dg+++  +++++++kgptl +ik+e+++ifG+f+s++w   +   ++   d   flf++ + +fk + ++++    +a+ + ++d  +fG g
  EFC37928.1 253 LLYRGSRDGFQAVDFHSRCDYKGPTLSIIKSEHGNIFGGFTSEHWealQ--INDHKLDPTAFLFKIeNSTFKQFEPRNQIcqsYAMGCGKNDLCVFGAG 349
                 69*******************************************7542..335678899******988999999944434435555666666999985 PP

         TLD  93 qpkfsLwidsslekgtsrhs..etfengllsg..........aseerfkikdiEVWgl 138
                    ++L i +++++++s      t++ +   +           ++ +fk+++iEV+++
  EFC37928.1 350 ---HDLRIVNNCNSSESYANlgRTYHLPNGYKfeteearsylGGSRKFKVTEIEVFRI 404
                 ...6888888888877777777888844444445778888**99***********986 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   7.4e-07   0.00089       1      86 [.     117     209 ..     117     217 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 7.4e-07
                 EEEEETTEEEEEEHHH.HHTSTTSTTTSSGG........GGEETTTTEEEE-S-HHHHHHHHHHHHS...S-B---TTS-HHHHHHHHHHHT- CS
       BTB_2   1 vklnVgGtrfetskst.LsrkpdtlLgkllkte....elddydeetneyffDRspklFetiLnyyrtg..gkLhrpeevelkslleElefygl 86 
                 ++lnV G+++ +sk+  +++ pd l+gk+   e     + +   ++  yf+D +p++F++++n++++    +++++e+vel+ + +  +  +l
  EFC37928.1 117 IHLNVRGVIMTISKKPfIENEPDNLFGKMFIGEipmhATPSPLFSDPVYFVDVDPTIFKHVINWFQNSvlNDIPNSERVELRHVCDSYKLTNL 209
                 689*********998626777*********999665423333445678*******************64445566666665555554444444 PP

>> BTB_3  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   4.5e-06    0.0054      13      88 ..     128     204 ..     117     216 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 4.5e-06
       BTB_3  13 vdke.lfrahPdtllgrmfgsslesnltkpnekGeyevaegisaevfraildyykkGvikcPpgvsvkelreacdyl 88 
                 ++k+  ++++Pd l+g+mf   +  ++t +    + +    +  ++f+ +++++++ v++  p+    elr+ cd +
  EFC37928.1 128 ISKKpFIENEPDNLFGKMFIGEIPMHATPSPLFSDPVYFVDVDPTIFKHVINWFQNSVLNDIPNSERVELRHVCDSY 204
                 4444156789*********9999888887777777788889******************9877778889*****955 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1  11.2   1.3e-05     0.016       2      40 .]      21      55 ..      20      55 .. 0.96
   2 ?   -0.8   0.7       1.2   1.5e+03      17      38 ..      84     103 ..      74     104 .. 0.49

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.3e-05
  zf-C3HC4_2  2 CpiCldmlkdpsvvtpCgHvfCqkCilrsLeekneCPlC 40
                C+iC   l +p++ ++Cg  +C kCi  +    ++CP+C
  EFC37928.1 21 CQICNLPLVNPLTHAACGMMYCFKCIELT----ENCPTC 55
                **************************996....89**** PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.2
  zf-C3HC4_2  17 pCgHvfCqkCilrsLeekneCP 38 
                 +Cg v C+  +       n+CP
  EFC37928.1  84 ECGSVMCRGELIDH--IDNHCP 103
                 44444444322221..234777 PP

>> Lar_restr_allev  Restriction alleviation protein Lar
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.4         6   7.2e+03      22      34 ..      37      45 ..      16      51 .. 0.58
   2 ?   13.6   0.9   5.4e-05     0.065       4      36 ..      50      87 ..      46     115 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 6
  Lar_restr_allev 22 vaeigqcvyCadC 34
                           ++yC +C
       EFC37928.1 37 CG----MMYCFKC 45
                     22....4555545 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 5.4e-05
  Lar_restr_allev  4 kpCPfCggravlersqrvvaeigq.....cvyCadCga 36
                     + CP Cgg+  + ++   +++i        v+C++Cg 
       EFC37928.1 50 ENCPTCGGESLKSTAIPAPKSITNmlsklKVSCEECGS 87
                     57*****************99999*************9 PP

>> zf-C3H2C3  Zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   8.4   0.00019      0.22       1      35 []      21      56 ..      21      56 .. 0.96

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00019
   zf-C3H2C3  1 CdnCglkLdypfvaysCkHlvHakC.adeevCPkCk 35
                C +C l+L  p+ +  C  ++  kC    e CP+C+
  EFC37928.1 21 CQICNLPLVNPLTHAACGMMYCFKCiELTENCPTCG 56
                *************************87899*****7 PP

>> zf-TRAF  TRAF-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   1.2   8.1e-05     0.096       7      35 ..      77     103 ..      73     108 .. 0.85
   2 ?   -1.7   0.1       4.2   5.1e+03      38      50 ..     328     340 ..     325     343 .. 0.67

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 8.1e-05
                 SSEEE-TT--S-BEEETTTCCCCCCTTST CS
     zf-TRAF   7 fapvpCpnecckkkilRkdlkdHlekdCk 35 
                 + +v C+ ec+   + R +l dH+++ C+
  EFC37928.1  77 KLKVSCE-ECG-SVMCRGELIDHIDNHCP 103
                 7799**4.476.77**************8 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 4.2
                 --XXSSXXXXSXX CS
     zf-TRAF  38 evkCkfkevGCke 50 
                 ++ C+  ++GC +
  EFC37928.1 328 NQICQSYAMGCGK 340
                 5567766888865 PP

>> E6  Early Protein (E6)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   3.7   0.00022      0.26      13      97 ..      18     105 ..       9     112 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00022
                 HHHHHHTTXBXE...EETTEEEBXXHHHHHHHHHHHHHHHEEEEEEHHHHHHHHTSTGGGSEEEETTT--B--HHHHHHHHHTTSEEE CS
          E6  13 allfkekklslv...wreglpygvCkkClevlallelllhlerslkakeleelvgkslsdleiRCvvClklLskeeKeellekkesft 97 
                  ll++ ++l lv    +  + +  C kC+e++    ++   + + +a  + + + + ls+l++ C  C++++++ e  ++++++ ++ 
  EFC37928.1  18 NLLCQICNLPLVnplTHAACGMMYCFKCIELTENCPTCGGESLKSTAIPAPKSITNMLSKLKVSCEECGSVMCRGELIDHIDNHCPVI 105
                 556666777666222466777788****************999999*********************************999987765 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   6.7   3.5e-05     0.042       2      45 ..      18      57 ..      17      61 .. 0.85
   2 ?    0.1   0.9      0.64   7.7e+02      25      41 ..      81     103 ..      74     104 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.5e-05
                GSB-TTTSSSBS-E.EETTEEEEEE-HHHHHHHHHTT-B-TTT-- CS
  zf-C3HC4_3  2 deeCviClerprnv.vllpCgHlvlCeeCaekllkrkkkCpiCrr 45
                + +C+iC+    n  +   Cg + +C +C e      ++Cp C  
  EFC37928.1 18 NLLCQICNLPLVNPlTHAACGMM-YCFKCIELT----ENCPTCGG 57
                689*******9996155579999.*********....******75 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.64
                 E-HHHHHHHHH......TT-B-T CS
  zf-C3HC4_3  25 lCeeCaekllk......rkkkCp 41 
                  CeeC + + +       +++Cp
  EFC37928.1  81 SCEECGSVMCRgelidhIDNHCP 103
                 67777777666556556677777 PP

>> Mu-like_Com  Mu-like prophage protein Com
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.7      0.27   3.2e+02      22      31 ..      47      56 ..      42      64 .. 0.86
   2 ?   10.7   0.6   0.00023      0.28       4      28 ..      79     103 ..      76     105 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.27
  Mu-like_Com 22 eltiKCPRCG 31
                 elt  CP CG
   EFC37928.1 47 ELTENCPTCG 56
                 68889****9 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00023
  Mu-like_Com   4 elRCGeCaRLLaKaeAlDeltiKCP 28 
                  ++ C eC  +++++e +D +   CP
   EFC37928.1  79 KVSCEECGSVMCRGELIDHIDNHCP 103
                  588*********************9 PP

>> zf_C2H2_13  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.3         8   9.6e+03       9      21 ..      13      25 ..      13      26 .. 0.74
   2 ?   11.5   2.6   0.00015      0.17      20      40 ..      82     102 ..      74     103 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 8
  zf_C2H2_13  9 dpLdtnlnYRvCn 21
                +++d+nl   +Cn
  EFC37928.1 13 NSIDENLLCQICN 25
                6778887778887 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.00015
  zf_C2H2_13  20 CnkCGkPisleaivdHLenhC 40 
                 C++CG  +    ++dH++nhC
  EFC37928.1  82 CEECGSVMCRGELIDHIDNHC 102
                 ********************* PP

>> zf-C2HC5  Putative zinc finger motif, C2HC5-type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   7.5      0.53   6.3e+02      21      47 ..      35      62 ..      20      67 .. 0.75
   2 ?   11.3   0.8   0.00022      0.27      13      38 ..      75     103 ..      72     113 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.53
    zf-C2HC5 21 lnCGkiiCakegls.kpCsfCgspllss 47
                 +CG   C k     ++C+ Cg + l+s
  EFC37928.1 35 AACGMMYCFKCIELtENCPTCGGESLKS 62
                47******8764444******9665555 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00022
    zf-C2HC5  13 LleaapnClnCGkiiCakegls...kpCs 38 
                 L+++   C +CG ++C  e +    ++C+
  EFC37928.1  75 LSKLKVSCEECGSVMCRGELIDhidNHCP 103
                 7788889**********999874555554 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   8.7   0.00066      0.79       3      43 ..      21      55 ..      19      56 .. 0.75
   2 ?    1.0   0.9      0.47   5.6e+02      16      41 ..      80     103 ..      72     104 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00066
   zf-RING_2  3 CpICleelssadsvlllpCgHvfhreClerwlrssstCPlC 43
                C IC  +l   + ++   Cg +++++C+e     +++CP+C
  EFC37928.1 21 CQICNLPLV--NPLTHAACGMMYCFKCIEL----TENCPTC 55
                ****87886..3444446*********854....5569999 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.47
   zf-RING_2  16 vlllpCgHvfhreClerwlrssstCP 41 
                 v +++Cg v++r  l +++ ++  CP
  EFC37928.1  80 VSCEECGSVMCRGELIDHIDNH--CP 103
                 4555799999887666655554..87 PP

>> DUF1272  Protein of unknown function (DUF1272)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   6.2   0.00056      0.66       8      50 ..      21      58 ..      17      62 .. 0.79
   2 ?    0.2   0.6       0.7   8.4e+02       3      14 ..      77      88 ..      74     103 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00056
     DUF1272  8 CecCdkdlppdseearicsyEctFCaeCaeevlenvCPncgGe 50
                C+ C+  l +  ++a  c     +C +C e +  + CP cgGe
  EFC37928.1 21 CQICNLPLVNPLTHAA-C--GMMYCFKCIELT--ENCPTCGGE 58
                8888888888776664.4..3579****9966..9*******9 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.7
     DUF1272  3 elrpnCecCdkd 14
                +l+ +Ce C   
  EFC37928.1 77 KLKVSCEECGSV 88
                578888888754 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   7.1   0.00091       1.1       1      26 [.      21      47 ..      21      55 .. 0.86
   2 ?   -1.1   0.4       1.9   2.3e+03      15      22 ..      84      91 ..      77      94 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00091
  zf-C3HC4_4  1 CPiCldYLekPvs.leCGhsfClsCis 26
                C iC   L +P +  +CG  +C++Ci+
  EFC37928.1 21 CQICNLPLVNPLThAACGMMYCFKCIE 47
                99*********87468**********7 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.9
  zf-C3HC4_4 15 eCGhsfCl 22
                eCG ++C 
  EFC37928.1 84 ECGSVMCR 91
                68888885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       713  (0.039768); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.65u 0.27s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2500.68
//
Query:       EFC37929.1  [L=1074]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-94  305.4  14.6    6.4e-08   32.2   0.0   16.6 16  NHL             NHL repeat
    1.8e-12   47.4  13.2    0.00042   20.0   0.6    6.9  8  SGL             SMP-30/Gluconolactonase/LRE-like region
    9.2e-12   45.5   4.9       0.35   10.8   0.1   10.5 12  Phytase-like    Esterase-like activity of phytase
    1.9e-05   24.7   2.7        3.4    7.9   0.0    7.8  9  Str_synth       Strictosidine synthase
  ------ inclusion threshold ------
       0.14   11.9   4.7         85    3.1   0.0    6.1  9  DUF4431         Domain of unknown function (DUF4431)
        3.9    7.9  14.6         80    3.7   0.0    7.9 11  Linker_histone  linker histone H1 and H5 family


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.0     0.011        33       1      27 [.      37      63 ..      37      64 .. 0.90
   2 !    5.8   0.0    0.0053        16       2      25 ..      93     116 ..      93     118 .. 0.87
   3 !   13.2   0.0   2.3e-05      0.07       1      23 [.     149     172 ..     149     176 .. 0.89
   4 !   18.6   0.0   4.6e-07    0.0014       9      27 ..     212     231 ..     211     232 .. 0.88
   5 !   27.3   0.0   7.8e-10   2.3e-06       1      27 [.     261     287 ..     261     288 .. 0.96
   6 !   24.5   0.0     6e-09   1.8e-05       1      27 [.     317     343 ..     317     344 .. 0.94
   7 ?    2.0   0.0     0.084   2.5e+02       2      27 ..     461     486 ..     460     487 .. 0.84
   8 !   24.7   0.0   5.2e-09   1.5e-05       1      27 [.     515     541 ..     515     542 .. 0.95
   9 !   19.8   0.0   1.8e-07   0.00055       3      27 ..     573     597 ..     572     598 .. 0.95
  10 !   24.3   0.1   7.3e-09   2.2e-05       7      27 ..     637     658 ..     634     659 .. 0.94
  11 !   13.3   0.0   2.1e-05     0.064       1      27 [.     689     715 ..     689     716 .. 0.92
  12 !   20.7   0.0   9.5e-08   0.00028       1      27 [.     745     771 ..     745     772 .. 0.96
  13 !   19.4   0.0   2.5e-07   0.00076       8      27 ..     801     821 ..     798     822 .. 0.88
  14 !   27.1   0.1     9e-10   2.7e-06       1      27 [.     851     877 ..     851     878 .. 0.95
  15 !   32.2   0.0   2.2e-11   6.4e-08       1      27 [.     907     933 ..     907     934 .. 0.96
  16 !   18.1   0.0   6.5e-07     0.002       1      27 [.     963     989 ..     963     990 .. 0.94

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.011
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                ++yP G+a+  n +i++aD+ n+r+++
  EFC37929.1 37 LRYPYGIALGLNSEILIADTFNQRIRK 63
                6899999999999***********986 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0053
                 SSEEEEEEETTTEEEEEECCCTEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrv 25 
                 n+P Gv v+s G+ ++aD+ nh +
  EFC37929.1  93 NFPYGVIVNSLGETFIADTSNHVI 116
                 5788999***************55 PP

  == domain 3  score: 13.2 bits;  conditional E-value: 2.3e-05
                 BSSEEEEEEE.TTTEEEEEECCCT CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenh 23 
                 +n+P G+a++ s+G++++ D+ n+
  EFC37929.1 149 LNSPYGLALNsSSGEVIIVDTSNN 172
                 78999***************8887 PP

  == domain 4  score: 18.6 bits;  conditional E-value: 4.6e-07
                 EE.TTTEEEEEECCCTEEEE CS
         NHL   9 vd.snGdiyVaDsenhrvqv 27 
                 ++ snG+++VaDs+nhr+++
  EFC37929.1 212 AFySNGELFVADSRNHRIRK 231
                 5669**************97 PP

  == domain 5  score: 27.3 bits;  conditional E-value: 7.8e-10
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+G++v+snG+i+++Ds n+r+++
  EFC37929.1 261 LNYPSGISVNSNGEIFISDSVNNRIRK 287
                 79***********************87 PP

  == domain 6  score: 24.5 bits;  conditional E-value: 6e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 ++ P+G++v+s G+i+++Ds+nhr+++
  EFC37929.1 317 LWLPSGIVVNSVGEIFISDSYNHRIRK 343
                 678**********************97 PP

  == domain 7  score: 2.0 bits;  conditional E-value: 0.084
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                  +P+++ ++snGd y +Ds nh +++
  EFC37929.1 461 HNPNSIFISSNGDSYFSDSSNHKIRK 486
                 57888888999999999*****9986 PP

  == domain 8  score: 24.7 bits;  conditional E-value: 5.2e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P Gv+v+s+G+iy +Dsenhr+++
  EFC37929.1 515 LNNPKGVVVSSSGEIYFSDSENHRIRK 541
                 79***********************97 PP

  == domain 9  score: 19.8 bits;  conditional E-value: 1.8e-07
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                 yP+G+a++snG+++ +D++n+r+++
  EFC37929.1 573 YPNGIAMNSNGELIFTDTRNNRIRK 597
                 8**********************86 PP

  == domain 10  score: 24.3 bits;  conditional E-value: 7.3e-09
                 EEEE.TTTEEEEEECCCTEEEE CS
         NHL   7 vavd.snGdiyVaDsenhrvqv 27 
                 vav+ +n+diy+aDs+nhr+++
  EFC37929.1 637 VAVNlTNNDIYIADSGNHRIRK 658
                 9*******************86 PP

  == domain 11  score: 13.3 bits;  conditional E-value: 2.1e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P ++++ ++G+iy++D +n+rv++
  EFC37929.1 689 LNFPFSISIGNSGEIYISDQYNQRVRK 715
                 6788899******************86 PP

  == domain 12  score: 20.7 bits;  conditional E-value: 9.5e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 fnyP+Gv+ +snGd+++ Ds n+r+++
  EFC37929.1 745 FNYPSGVSSNSNGDVFIIDSFNSRIRK 771
                 9************************87 PP

  == domain 13  score: 19.4 bits;  conditional E-value: 2.5e-07
                 EEE.TTTEEEEEECCCTEEEE CS
         NHL   8 avd.snGdiyVaDsenhrvqv 27 
                 a++ ++G+i++aDs+nhr+++
  EFC37929.1 801 AISsKSGEIFIADSNNHRIRK 821
                 78889**************97 PP

  == domain 14  score: 27.1 bits;  conditional E-value: 9e-10
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+ vav+snG+++++D++nhr+++
  EFC37929.1 851 LNNPSYVAVNSNGELLISDTNNHRIRK 877
                 799**********************86 PP

  == domain 15  score: 32.2 bits;  conditional E-value: 2.2e-11
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+G++v+s+Gd+++aDs+nhr+++
  EFC37929.1 907 LNYPSGLVVSSTGDLFIADSYNHRIRK 933
                 79***********************97 PP

  == domain 16  score: 18.1 bits;  conditional E-value: 6.5e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+G+av+s G++y++D  n+r+++
  EFC37929.1 963 LNFPTGLAVSSVGELYISDDSNNRIRK 989
                 79*****************99999985 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.023        70     147     217 ..      50     126 ..      39     132 .. 0.77
   2 !   11.9   0.2   4.1e-05      0.12      30     216 ..     140     350 ..     131     355 .. 0.78
   3 !   15.5   0.1   3.3e-06      0.01      11     214 ..     328     546 ..     319     552 .. 0.76
   4 !   20.0   0.6   1.4e-07   0.00042      12     232 ..     381     619 ..     372     623 .. 0.73
   5 !   15.7   0.2   2.9e-06    0.0086      91     212 ..     521     661 ..     514     674 .. 0.70
   6 !    7.3   0.2     0.001         3     136     209 ..     574     658 ..     573     725 .. 0.56
   7 !    6.8   0.5    0.0015       4.4      91     229 ..     751     886 ..     642     896 .. 0.68
   8 !    6.5   0.0    0.0018       5.3      99     217 ..     865     941 ..     857     996 .. 0.49

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.023
         SGL 147 tlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGkli 217
                  +++aD+ +++i +++ ++ ++  +  +  + ++ +       + p G++v + G+ ++A  +++ +++++++Gk+ 
  EFC37929.1  50 EILIADTFNQRIRKVSSSDVSTFAGVGTSSFSGDGALatqseiNFPYGVIVNSLGETFIADTSNHVIRKVSTNGKIS 126
                 55678999999888888777775544444455555557777666699***************************975 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 4.1e-05
         SGL  30 atgketvldtpesvGaiaprkdgrlvvasksglalldlas.geletladeee.......dekpllrfND..gvvdpdGrlwfGtmgdeeakgeev.gal 117
                 ++g  t + ++++ G++ +  +g++++  +s+ ++ +++s g+++t+a           ++ ++++fN   +++ ++G+l++ + ++++ ++ ++ g +
  EFC37929.1 140 DGGLATNALLNSPYGLALNSSSGEVIIVDTSNNVIRKVSSiGNITTIAGTGAagysgdnGQATNAKFNAprAAFYSNGELFVADSRNHRIRKISNsGIV 238
                 5666666777889999999777999999999998885444378888887722344455588899999973366789*******9999999999887666 PP

         SGL 118 yrldpdgk.......lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAvw 202
                   + + g+       +     +l+ p G+ +++ g+ ++  Ds++++i ++  + +  ++    ++ + ++ g         p G++v + G++++   
  EFC37929.1 239 TTVAGTGTagfngdsILAKNAQLNYPSGISVNSNGEIFI-SDSVNNRIRKILTNGTIITIAGTGTVgLSGDGGLavnaqlWLPSGIVVNSVGEIFISDS 336
                 66666655566666577778899999*******999988.9**********999888888888888566666659988765599*************99 PP

         SGL 203 gggkvvrfdpdGkl 216
                  ++++++++  G +
  EFC37929.1 337 YNHRIRKISASGVI 350
                 99999999999964 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 3.3e-06
         SGL  11 egaLlwvDilgqrihrldpatgketvldtpe.......svGaiaprkd.....grlvvasksglalldlasgeletladeee.dekpllrfNDgvvdpd 96 
                  g+++ +D ++ ri ++++++  +t++ t++       s +++ p+ +     ++l+++ +++++++dl++  ++tl + ++ +   +   N++ v   
  EFC37929.1 328 VGEIFISDSYNHRIRKISASGVISTFAGTSSfgedvqaSKSFVSPNGNpiiygNNLLFTDNGKVRRVDLSTNVISTLSSVTPlGSAVSYYNNEVYVMYL 426
                 6778888999999999999998888855555555555566666663334555599****************9999999997756667888899999888 PP

         SGL  97 GrlwfGtmgdeeakgeevgalyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge......gepDGl 189
                 G  +    + +  +   +ga+   +  g    + ++l+ pN + +s+ g+  Y+ Ds ++ki + +    ++  +  +  + ++         ++p G+
  EFC37929.1 427 G-SYLSKIKSSLTAVAGTGAIGADS--GDGLAITERLHNPNSIFISSNGDS-YFSDSSNHKIRKLSNGYITTIAGTGTSGYSGDGSSatsaklNNPKGV 521
                 8.56666666666665445544433..456678899**********99985.99*********99998888866666666777777788888877**** PP

         SGL 190 avDaeGnvwvAvwgggkvvrfdpdG 214
                 +v ++G+++    ++++++++++ G
  EFC37929.1 522 VVSSSGEIYFSDSENHRIRKISTGG 546
                 *********************9988 PP

  == domain 4  score: 20.0 bits;  conditional E-value: 1.4e-07
         SGL  12 gaLlwvDilgqrihrldpatgketvldtpesvGaiaprkdgrlvvasksglalldlasgeletladeee...........dekpllrfNDgvvdpdGrl 99 
                 + Ll++D   +++ r+d++t+  ++l+   ++G+++ + +++++v +  g +l +++s +l+ +a                e +l+ +N + ++++G  
  EFC37929.1 381 NNLLFTDN--GKVRRVDLSTNVISTLSSVTPLGSAVSYYNNEVYV-MYLGSYLSKIKS-SLTAVAGTGAigadsgdglaiTE-RLHNPNSIFISSNGDS 474
                 67888875..89999999999999999999999999955555554.556666666666.56666655223334455666555.8999999999999999 PP

         SGL 100 wfGtmgdeeakgeevgalyrldpdgk.......lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......g 184
                 +f + ++++ ++ ++g +  + + g+        + +  +l+ p G+ +s+ g+ +Y+ Ds +++i +++     +++       + ++ g        
  EFC37929.1 475 YFSDSSNHKIRKLSNGYITTIAGTGTsgysgdgSSATSAKLNNPKGVVVSSSGE-IYFSDSENHRIRKISTGGIISTVAGSGESgFSGDGGLaisakiH 572
                 999999999999999999988888555888888888889999999999998875.79999999999999886555544444433355555558888888 PP

         SGL 185 epDGlavDaeGnvwvAvwgggkvvrfdpdGklieeiklpakrvtscaF 232
                 +p G+a+ ++G+++ +  ++++++++++ G  i +i+   ++    +F
  EFC37929.1 573 YPNGIAMNSNGELIFTDTRNNRIRKVSTSGY-ISTIAGNGTVAYKATF 619
                 8999999999999999999999999999996.4445555555555555 PP

  == domain 5  score: 15.7 bits;  conditional E-value: 2.9e-06
         SGL  91 gvvdpdGrlwfGtmgdeeakgeevgalyrldpd.gk.......lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlk 180
                 +vv++ G+++f + ++++ ++ ++g+++   ++ g+          +  +++ pNG+a+++ g+ l+++D+++++i +++ +   +++    ++ ++ +
  EFC37929.1 521 VVVSSSGEIYFSDSENHRIRKISTGGIISTVAGsGEsgfsgdgGLAISAKIHYPNGIAMNSNGE-LIFTDTRNNRIRKVSTSGYISTIAGNGTVaYKAT 618
                 78999*************99999966666555546668888876678899**********9886.567**********999877666654444425444 PP

         SGL 181 kge..........gepDGlavDa.eGnvwvAvwgggkvvrfdp 212
                   +           +p  +av   ++ +++A  g++++++++ 
  EFC37929.1 619 FSGdnglainaqlFVPFAVAVNLtNNDIYIADSGNHRIRKVSS 661
                 4444455665555446666666555556666666666666555 PP

  == domain 6  score: 7.3 bits;  conditional E-value: 0.001
         SGL 136 pNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge..........gepDGlavDa.eGnvwvAvwgggkvvr 209
                 pNG+a+++ g+ l+++D+++++i +++ +   +++    ++ ++ +  +           +p  +av   ++ +++A  g++++++
  EFC37929.1 574 PNGIAMNSNGE-LIFTDTRNNRIRKVSTSGYISTIAGNGTVaYKATFSGdnglainaqlFVPFAVAVNLtNNDIYIADSGNHRIRK 658
                 56666655554.33466666666655555443333332222133222222233333333223333333333333333333333333 PP

  == domain 7  score: 6.8 bits;  conditional E-value: 0.0015
         SGL  91 gvvdpdGrlwfGtmgdeeakgeevgalyrldpd.gklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkgegepDG 188
                 +   ++G +++ +  +++ ++ + g++  + ++ g  +  +++   +   a+s+ +  +++aDs +++i ++  + + +++     +a ++ ++    G
  EFC37929.1 751 VSSNSNGDVFIIDSFNSRIRKLSSGKISTVAGGlGDGSSAVNSYLNSQSFAISSKSGEIFIADSNNHRIRKIATNGDISTVAGSG-VAGFSGDG----G 844
                 4556677777766666777777779999999999999999999999999999999999999999999999999988888777666.44665555....5 PP

         SGL 189 lavDa..eGnvwvAvwgggkvvrfdpdGklieeiklpakrvts 229
                 la+ a  ++  +vAv ++g++   d++   i++++l   ++t 
  EFC37929.1 845 LATSAtlNNPSYVAVNSNGELLISDTNNHRIRKVSLN-GIITT 886
                 5655555666677777777777777776667666666.44444 PP

  == domain 8  score: 6.5 bits;  conditional E-value: 0.0018
         SGL  99 lwfGtmgdeeakgeevgalyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGla 190
                 l +                                                  D+ +++i +++++   +++    +  ++++ ++      ++p Gl+
  EFC37929.1 865 LLI-------------------------------------------------SDTNNHRIRKVSLNGIITTIAGNGTAgYNGEGNNaslyqlNYPSGLV 914
                 333.................................................44555555555544444444333333344444444444444455555 PP

         SGL 191 vDaeGnvwvAvwgggkvvrfdpdGkli 217
                 v ++G +++A   ++++++++ +G++ 
  EFC37929.1 915 VSSTGDLFIADSYNHRIRKLNVNGTIS 941
                 555555555555555555555544432 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       2.7   8.2e+03      75     100 ..     100     125 ..      97     133 .. 0.84
   2 ?    0.5   0.0      0.16   4.8e+02      74     101 ..     212     239 ..     159     262 .. 0.81
   3 ?    3.4   0.0      0.02        61      72     100 ..     266     294 ..     197     300 .. 0.81
   4 !   10.8   0.1   0.00012      0.35      21     100 ..     277     350 ..     265     369 .. 0.77
   5 ?   -1.5   0.0      0.63   1.9e+03      43      95 ..     436     488 ..     421     496 .. 0.80
   6 ?    2.9   0.0     0.029        88      59      99 ..     506     547 ..     473     554 .. 0.76
   7 ?    0.7   0.0      0.13     4e+02      72     100 ..     576     604 ..     573     622 .. 0.92
   8 ?    0.9   0.0      0.12   3.7e+02      74     100 ..     638     666 ..     634     687 .. 0.81
   9 ?    1.0   0.0      0.11   3.2e+02      72     100 ..     694     722 ..     692     726 .. 0.90
  10 ?    1.9   0.0      0.06   1.8e+02      67     101 ..     794     829 ..     768     840 .. 0.85
  11 !    7.3   0.0    0.0013         4      72     101 ..     912     941 ..     853     945 .. 0.84
  12 ?    1.1   0.0       0.1     3e+02      72      97 ..     968     993 ..     966    1017 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.7
  Phytase-like  75 vapdgtfwvssEggpfilefdadGkl 100
                   v++ g+ ++++  ++ i++++ +Gk+
    EFC37929.1 100 VNSLGETFIADTSNHVIRKVSTNGKI 125
                   5667889999999***********98 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.16
  Phytase-like  74 avapdgtfwvssEggpfilefdadGkll 101
                   a+ ++g+++v++ ++++i++++ +G ++
    EFC37929.1 212 AFYSNGELFVADSRNHRIRKISNSGIVT 239
                   55689*****************999765 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.02
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkl 100
                   gi v+++g++++s+  +++i+++  +G++
    EFC37929.1 266 GISVNSNGEIFISDSVNNRIRKILTNGTI 294
                   89999999999999999999999999887 PP

  == domain 4  score: 10.8 bits;  conditional E-value: 0.00012
  Phytase-like  21 lsDrgsknsarfytlkldldadklgkveitevtplkdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefdadGkl 100
                   +sD+      r+   +  l+++ + +++ t+++ l  + g +++ + + p gi+v++ g++++s+ ++++i++++a+G +
    EFC37929.1 277 ISDSVN---NRI---RKILTNGTIITIAGTGTVGLSGDGGLAVNAQLWLPSGIVVNSVGEIFISDSYNHRIRKISASGVI 350
                   555555...222...222344567888899999999999999988888999**************************987 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 0.63
  Phytase-like  43 klgkveitevtplkdpdgapfpkkglDpEgiavapdgtfwvssEggpfilefd 95 
                   +l++v+ t+++     dg +++++  +p +i ++++g+ ++s+  ++ i++ +
    EFC37929.1 436 SLTAVAGTGAIGADSGDGLAITERLHNPNSIFISSNGDSYFSDSSNHKIRKLS 488
                   66777788888888888888877777999999999999999999999999886 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.029
  Phytase-like  59 dgapfpkkgl.DpEgiavapdgtfwvssEggpfilefdadGk 99 
                   dg+  ++ +l +p g++v++ g++++s+  +++i++++  G 
    EFC37929.1 506 DGSSATSAKLnNPKGVVVSSSGEIYFSDSENHRIRKISTGGI 547
                   456666666668889**********************98775 PP

  == domain 7  score: 0.7 bits;  conditional E-value: 0.13
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkl 100
                   gia++++g++++++ ++++i++++ +G +
    EFC37929.1 576 GIAMNSNGELIFTDTRNNRIRKVSTSGYI 604
                   89**********************99976 PP

  == domain 8  score: 0.9 bits;  conditional E-value: 0.12
  Phytase-like  74 av.apdgtfwvssEggpfilefdad.Gkl 100
                   av   ++++++++ g+++i++++ + G +
    EFC37929.1 638 AVnLTNNDIYIADSGNHRIRKVSSSsGII 666
                   5556899***************9885544 PP

  == domain 9  score: 1.0 bits;  conditional E-value: 0.11
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkl 100
                   +i + + g++++s+ ++ +++++ a+G +
    EFC37929.1 694 SISIGNSGEIYISDQYNQRVRKVAANGYI 722
                   6788899*******************976 PP

  == domain 10  score: 1.9 bits;  conditional E-value: 0.06
  Phytase-like  67 glDpEgiav.apdgtfwvssEggpfilefdadGkll 101
                    l++ ++a+ ++ g++++++  +++i+++  +G + 
    EFC37929.1 794 YLNSQSFAIsSKSGEIFIADSNNHRIRKIATNGDIS 829
                   456678999999********************9875 PP

  == domain 11  score: 7.3 bits;  conditional E-value: 0.0013
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkll 101
                   g++v+++g++++++ ++++i++ + +G++ 
    EFC37929.1 912 GLVVSSTGDLFIADSYNHRIRKLNVNGTIS 941
                   89999*********************9985 PP

  == domain 12  score: 1.1 bits;  conditional E-value: 0.1
  Phytase-like  72 giavapdgtfwvssEggpfilefdad 97 
                   g+av++ g++++s+  +++i++++++
    EFC37929.1 968 GLAVSSVGELYISDDSNNRIRKVSLT 993
                   899999*****************987 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0         2     6e+03      56      83 ..      37      63 ..      36      65 .. 0.77
   2 ?   -1.8   0.0       1.1   3.4e+03      58      82 ..     151     175 ..     145     179 .. 0.69
   3 ?    2.8   0.0     0.042   1.2e+02      55      87 ..     260     291 ..     253     293 .. 0.78
   4 ?   -3.4   0.0       3.6   1.1e+04      36      53 ..     388     405 ..     383     424 .. 0.75
   5 ?    1.3   0.0      0.13   3.8e+02      53      77 ..     457     480 ..     454     492 .. 0.63
   6 ?    0.5   0.0      0.23   6.8e+02       5      21 ..     523     537 ..     519     553 .. 0.74
   7 !    7.9   0.0    0.0011       3.4      54      85 ..     569     599 ..     563     603 .. 0.86
   8 ?   -0.2   0.0      0.37   1.1e+03      53      80 ..     904     930 ..     855     939 .. 0.67
   9 ?    0.6   0.0      0.21   6.2e+02      55      73 ..     962     980 ..     960     992 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2
   Str_synth 56 LyfanGialsedgsfvlvcetamkrisr 83
                L ++ Gial  + + +l+++t  +ri +
  EFC37929.1 37 LRYPYGIALGLNSE-ILIADTFNQRIRK 63
                67889999999876.5667888888766 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.1
   Str_synth  58 fanGialsedgsfvlvcetamkris 82 
                  + G+al +    v++++t+ + i 
  EFC37929.1 151 SPYGLALNSSSGEVIIVDTSNNVIR 175
                 5667777777777777777766554 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.042
   Str_synth  55 kLyfanGialsedgsfvlvcetamkrisrywik 87 
                 +L ++ Gi++ ++g+ +++ +   +ri + +++
  EFC37929.1 260 QLNYPSGISVNSNGEIFIS-DSVNNRIRKILTN 291
                 6999**********99886.5556777777766 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 3.6
   Str_synth  36 tGrllkydkstkvvkvll 53 
                 +G++ + d st v+ +l 
  EFC37929.1 388 NGKVRRVDLSTNVISTLS 405
                 688888888888887764 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.13
   Str_synth  53 ldkLyfanGialsedgsfvlvceta 77 
                  ++L+ +n i +s++g++  +++ +
  EFC37929.1 457 TERLHNPNSIFISSNGDSY-FSDSS 480
                 5677777777777777664.33333 PP

  == domain 6  score: 0.5 bits;  conditional E-value: 0.23
   Str_synth   5 vdeetgvlyftdsSsky 21 
                 v +  g++yf+ds  ++
  EFC37929.1 523 VSS-SGEIYFSDSE-NH 537
                 444.5******974.44 PP

  == domain 7  score: 7.9 bits;  conditional E-value: 0.0011
   Str_synth  54 dkLyfanGialsedgsfvlvcetamkrisryw 85 
                  k++++nGia+ ++g+ +++++t  +ri +  
  EFC37929.1 569 AKIHYPNGIAMNSNGE-LIFTDTRNNRIRKVS 599
                 6899**********97.899*******98865 PP

  == domain 8  score: -0.2 bits;  conditional E-value: 0.37
   Str_synth  53 ldkLyfanGialsedgsfvlvcetamkr 80 
                 l +L ++ G+ +s+ g+ ++  +   +r
  EFC37929.1 904 LYQLNYPSGLVVSSTGDLFIA-DSYNHR 930
                 557888899999988887764.444455 PP

  == domain 9  score: 0.6 bits;  conditional E-value: 0.21
   Str_synth  55 kLyfanGialsedgsfvlv 73 
                 +L f+ G+a+s+ g+  ++
  EFC37929.1 962 QLNFPTGLAVSSVGELYIS 980
                 6888888888887776554 PP

>> DUF4431  Domain of unknown function (DUF4431)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.7   5.2e+03      26      36 ..     104     114 ..     102     114 .. 0.94
   2 ?    0.7   0.0      0.16   4.6e+02      26      37 ..     217     228 ..     216     228 .. 0.91
   3 ?   -2.2   0.0       1.3   3.7e+03      26      37 ..     329     340 ..     325     340 .. 0.88
   4 ?   -3.3   0.1       2.7     8e+03      26      37 ..     472     483 ..     471     483 .. 0.86
   5 ?    3.1   0.0     0.028        85      19      37 ..     520     538 ..     508     538 .. 0.72
   6 ?   -2.2   0.0       1.3   3.8e+03      27      37 ..     645     655 ..     640     655 .. 0.90
   7 ?   -0.6   0.0       0.4   1.2e+03      25      37 ..     806     818 ..     806     818 .. 0.92
   8 ?   -1.8   0.0      0.91   2.7e+03      25      37 ..     862     874 ..     858     874 .. 0.89
   9 ?    2.0   0.0     0.062   1.8e+02      25      37 ..     918     930 ..     912     930 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.7
     DUF4431  26 GkLfhaqtghH 36 
                 G+ f a+t++H
  EFC37929.1 104 GETFIADTSNH 114
                 899*******9 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.16
     DUF4431  26 GkLfhaqtghHh 37 
                 G+Lf a++ +H+
  EFC37929.1 217 GELFVADSRNHR 228
                 9**********6 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 1.3
     DUF4431  26 GkLfhaqtghHh 37 
                 G++f +++ +H+
  EFC37929.1 329 GEIFISDSYNHR 340
                 9*******9995 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 2.7
     DUF4431  26 GkLfhaqtghHh 37 
                 G+ +++++++H+
  EFC37929.1 472 GDSYFSDSSNHK 483
                 8889*******5 PP

  == domain 5  score: 3.1 bits;  conditional E-value: 0.028
     DUF4431  19 GKeVkVtGkLfhaqtghHh 37 
                 G  V+ +G+++++++ +H+
  EFC37929.1 520 GVVVSSSGEIYFSDSENHR 538
                 4444456***********6 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 1.3
     DUF4431  27 kLfhaqtghHh 37 
                 +++ a++g+H+
  EFC37929.1 645 DIYIADSGNHR 655
                 799*******6 PP

  == domain 7  score: -0.6 bits;  conditional E-value: 0.4
     DUF4431  25 tGkLfhaqtghHh 37 
                 +G++f a++ +H+
  EFC37929.1 806 SGEIFIADSNNHR 818
                 69**********6 PP

  == domain 8  score: -1.8 bits;  conditional E-value: 0.91
     DUF4431  25 tGkLfhaqtghHh 37 
                 +G+L+ ++t +H+
  EFC37929.1 862 NGELLISDTNNHR 874
                 59**********6 PP

  == domain 9  score: 2.0 bits;  conditional E-value: 0.062
     DUF4431  25 tGkLfhaqtghHh 37 
                 tG+Lf a++ +H+
  EFC37929.1 918 TGDLFIADSYNHR 930
                 8********9995 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0         6   1.8e+04      47      67 ..     113     131 ..     111     135 .. 0.75
   2 ?   -1.8   0.0       1.4   4.2e+03      47      69 ..     171     193 ..     169     194 .. 0.89
   3 ?    1.7   0.0      0.11   3.4e+02      47      69 ..     226     248 ..     214     249 .. 0.90
   4 ?    3.7   0.0     0.027        80      42      69 ..     276     304 ..     255     307 .. 0.78
   5 ?   -2.1   0.0       1.8   5.3e+03      54      69 ..     487     502 ..     471     503 .. 0.83
   6 ?   -2.1   0.0       1.7   5.2e+03      47      69 ..     536     558 ..     531     561 .. 0.87
   7 ?   -0.1   0.0      0.43   1.3e+03      54      69 ..     661     676 ..     648     678 .. 0.84
   8 ?    0.5   0.0      0.27     8e+02      44      69 ..     707     732 ..     699     733 .. 0.89
   9 ?    1.7   0.0      0.11   3.3e+02      47      69 ..     816     838 ..     801     841 .. 0.89
  10 ?   -1.7   0.0       1.3     4e+03      47      69 ..     872     894 ..     864     895 .. 0.88
  11 ?   -2.3   0.0         2     6e+03      46      69 ..     927     950 ..     922     951 .. 0.87

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 6
  Linker_histone  47 kkalkkgvekgelvqpkgkGa 67 
                     ++ ++k  ++g++  + g  +
      EFC37929.1 113 NHVIRKVSTNGKISTIAG--T 131
                     567899999999998884..4 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.4
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k  + g ++ + g+Ga+G
      EFC37929.1 171 NNVIRKVSSIGNITTIAGTGAAG 193
                     6779999999***********98 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.11
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k  ++g+++ + g+G++G
      EFC37929.1 226 NHRIRKISNSGIVTTVAGTGTAG 248
                     7889****************998 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.027
  Linker_histone  42 f.ksllkkalkkgvekgelvqpkgkGasG 69 
                     f +  +++ ++k +++g+++ + g+G+ G
      EFC37929.1 276 FiSDSVNNRIRKILTNGTIITIAGTGTVG 304
                     4467899*****************98765 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 1.8
  Linker_histone  54 vekgelvqpkgkGasG 69 
                     +++g ++ + g+G+sG
      EFC37929.1 487 LSNGYITTIAGTGTSG 502
                     578999999****999 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 1.7
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k  + g++  + g+G sG
      EFC37929.1 536 NHRIRKISTGGIISTVAGSGESG 558
                     678999999********988887 PP

  == domain 7  score: -0.1 bits;  conditional E-value: 0.43
  Linker_histone  54 vekgelvqpkgkGasG 69 
                      ++g+++ + g+G+sG
      EFC37929.1 661 SSSGIITTVAGTGTSG 676
                     4689***********9 PP

  == domain 8  score: 0.5 bits;  conditional E-value: 0.27
  Linker_histone  44 sllkkalkkgvekgelvqpkgkGasG 69 
                      + ++ ++k +++g +  + g+Ga G
      EFC37929.1 707 DQYNQRVRKVAANGYISTIAGSGAIG 732
                     578999*****************987 PP

  == domain 9  score: 1.7 bits;  conditional E-value: 0.11
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k +++g++  + g+G++G
      EFC37929.1 816 NHRIRKIATNGDISTVAGSGVAG 838
                     7899**************99988 PP

  == domain 10  score: -1.7 bits;  conditional E-value: 1.3
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k   +g+++ + g+G++G
      EFC37929.1 872 NHRIRKVSLNGIITTIAGNGTAG 894
                     6789999999******9999988 PP

  == domain 11  score: -2.3 bits;  conditional E-value: 2
  Linker_histone  46 lkkalkkgvekgelvqpkgkGasG 69 
                      ++ ++k+  +g++    g+G++G
      EFC37929.1 927 YNHRIRKLNVNGTISTSAGNGIAG 950
                     5889999999*****999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1074 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.90u 0.32s 00:00:01.22 Elapsed: 00:00:00.53
# Mc/sec: 6116.67
//
Query:       EFC37930.1  [L=389]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       622  (0.0346924); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 2413.41
//
Query:       EFC37931.1  [L=887]
Description: silent information regulator family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-12   47.1   0.0    8.7e-12   45.3   0.0    1.9  2  SIR2      Sir2 family


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1      0.25   4.5e+03      16      43 ..     524     551 ..     516     570 .. 0.69
   2 !   45.3   0.0   4.8e-16   8.7e-12      47     173 ..     688     821 ..     661     825 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.25
                 TTSHHHHSCHHHHSSHHHHHHHHHHHHH CS
        SIR2  16 keGlyaklakeelaspealfskkllvee 43 
                 +eG y+ ++++++++++   + k++ +e
  EFC37931.1 524 EEGYYTTTSQKRIQKQSLTDQLKRKIQE 551
                 6788888888888877766665555444 PP

  == domain 2  score: 45.3 bits;  conditional E-value: 4.8e-16
                 HHHHHHHCCTSS--HHHHHHHHHHHTTCEEEEEES-SSSHHHHTT-SSEEETTEEEEEEEETTTSBEEECCGGHCHHHCCTT......B-TTTCC...B CS
        SIR2  47 niarellaeeaepnaaHkalkklekkgkllrliTQNiDgLekkaGskkvvelHGslakakcvkcekkldkeelqeeieaekvp.....ecekcgk...l 137
                 +++  + +  ++p+++ k+l  l++++k +r++   i +L  +   +kv+++ G+l +++c++cek++d ++  ++  +++vp     +ce++ k    
  EFC37931.1 688 KLTYGWSRIYKKPSKVLKFLMSLDEQEKIQRIYSESIEKLPFE--DEKVINCLGTLDSFTCSTCEKTFDFKTGAAMFPNKDVPtnkkgKCEQMAKkdcS 784
                 444456666889****************************876..68***********************99999988888886655566665558889 PP

                 EEEEE--CTSB-SHHHHHHHH.HHHH-SEEEEES--S CS
        SIR2 138 lkpdvvfFGealpdklkklie.kveeadlllviGtSl 173
                 lkp++ + Ge+ p+++++  + + e++dl++v+G  l
  EFC37931.1 785 LKPNILMLGESYPSSISDNKRsDFENCDLVVVLGVPL 821
                 *************888888887************765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (887 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1254  (0.0699426); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.24s 00:00:00.83 Elapsed: 00:00:00.41
# Mc/sec: 6461.99
//
Query:       EFC37932.1  [L=392]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.3e-07   29.6   6.0    8.7e-06   25.9   0.2    3.5  4  BTB       BTB/POZ domain
  ------ inclusion threshold ------
       0.02   14.6   5.4      0.095   12.3   0.2    2.6  2  STD1      STD1/MTH1
        3.2    7.8   5.3        3.2    7.8   2.3    2.4  2  DUF4024   Protein of unknown function (DUF4024)


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.74   4.4e+03      71     103 ..      52      84 ..      51      92 .. 0.76
   2 ?   -0.3   0.1      0.21   1.2e+03      34      95 ..      85     142 ..      80     161 .. 0.61
   3 !   25.9   0.2   1.5e-09   8.7e-06       2      44 ..     254     296 ..     253     306 .. 0.90
   4 !    4.8   0.1    0.0052        31      80     105 ..     304     329 ..     295     333 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.74
                 HHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHH CS
         BTB  71 iYtgeleitseenleelLaaadllqiprlkkac 103
                  Y+++lei+ ++   +lL   +++ +  l++++
  EFC37932.1  52 KYPQKLEIKLKKHSRDLLFKTSIYAFIPLIEIL 84 
                 599999998667788888888888887777765 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.21
                 -HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHHHHHT CS
         BTB  34 SpyFkalftskeieessvseielddvepeafealLefiYtgeleit.seenleelLaaadllq 95 
                 Sp F++l+ ++ +   s     l+  + +++++l++     e++++ +++++ ++L +  l+q
  EFC37932.1  85 SPLFSKLILKN-EPLIS----SLNSTQQQIIQNLIDSQLYNEIKLKfNDDEILNVLFILGLFQ 142
                 78888888888.22222....346666666666666654455555555666666666666665 PP

  == domain 3  score: 25.9 bits;  conditional E-value: 1.5e-09
                 HHHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST CS
         BTB   2 nelresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk 44 
                 n+l + ++ +D+ ++++++  +++hk +L++ S+ F+a+f  +
  EFC37932.1 254 NQLYNDKKTSDLKIQMDENNYLYCHKTILSSTSSLFNAMFDCG 296
                 899999**********************************865 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.0052
                 CGGGHHHHHHHHHHHT-HHHHHHHHH CS
         BTB  80 seenleelLaaadllqiprlkkacee 105
                 ++e++ +lL +a +++++ l+  c++
  EFC37932.1 304 KSEKIISLLDMAMKYEVKYLVIYCKN 329
                 5799******************9987 PP

>> STD1  STD1/MTH1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.2   1.6e-05     0.095     123     147 ..     102     126 ..      88     129 .. 0.91
   2 ?    3.9   1.0    0.0059        35      36      88 ..     273     332 ..     158     335 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.6e-05
        STD1 123 ldssdeeiietLvsSdlYkEhnldy 147
                 l+s++++ii+ L++S lY E +l +
  EFC37932.1 102 LNSTQQQIIQNLIDSQLYNEIKLKF 126
                 69********************987 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.0059
        STD1  36 l.....sdilledalpkqqk..............klddmynpeelkksllndellyngrpeeLiDWelNkiR 88 
                       +      +++   +              ++ d+ + e++++ ll+  ++++ + ++L+ +++N++R
  EFC37932.1 273 NylychK------TIL---SstsslfnamfdcgsTFADLNKSEKIIS-LLD--MAMKYEVKYLVIYCKNNFR 332
                 1223331......222...0222322233444457777777777775.555..455666779*********9 PP

>> DUF4024  Protein of unknown function (DUF4024)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   2.3   0.00053       3.2      13      31 ..     128     146 ..     121     149 .. 0.84
   2 ?   -0.5   0.1      0.22   1.3e+03      14      22 ..     270     277 ..     265     278 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00053
     DUF4024  13 RDEnvnFLFCiGFmqKnEL 31 
                  DE  n LF +G  q nE 
  EFC37932.1 128 DDEILNVLFILGLFQNNEF 146
                 58999*************7 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.22
     DUF4024  14 DEnvnFLFC 22 
                 DEn n+L+C
  EFC37932.1 270 DEN-NYLYC 277
                 888.99*99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (392 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       903  (0.0503653); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 2223.28
//
Query:       EFC37933.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1271  (0.0708907); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 960.16
//
Query:       EFC37934.1  [L=481]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-15   56.2  24.5    3.2e-08   33.2   7.8    3.1  3  ZZ        Zinc finger, ZZ type
     0.0067   16.7  31.3      0.012   15.9  10.6    4.2  4  C1_2      C1 domain
  ------ inclusion threshold ------
      0.063   12.2   0.0      0.096   11.6   0.0    1.1  1  DUF726    Protein of unknown function (DUF726)
       0.55    9.9   5.3         12    5.6   0.0    3.4  3  Sgf11     Sgf11 (transcriptional regulation protein)


Domain annotation for each model (and alignments):
>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.4      0.78   3.5e+03       6      12 ..     167     173 ..     163     175 .. 0.73
   2 !   33.2   7.8   7.1e-12   3.2e-08       4      37 ..     261     293 ..     260     300 .. 0.90
   3 !   33.1   2.7   7.9e-12   3.6e-08       5      37 ..     328     359 ..     326     365 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.78
                 E-TTT-S CS
          ZZ   6 tCdgCse 12 
                  C+ C+e
  EFC37934.1 167 NCENCKE 173
                 5777776 PP

  == domain 2  score: 33.2 bits;  conditional E-value: 7.1e-12
                 -EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH CS
          ZZ   4 kytCdgCseapligvRyhclrcsdYDLCqsCfst 37 
                 +++Cd+C e p+ g Ry cl c++YDLC  C  +
  EFC37934.1 261 EFSCDICEE-PIHGIRYNCLDCDEYDLCGYCCEK 293
                 699******.*******************99765 PP

  == domain 3  score: 33.1 bits;  conditional E-value: 7.9e-12
                 EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH CS
          ZZ   5 ytCdgCseapligvRyhclrcsdYDLCqsCfst 37 
                 y+C++C    + g+Ryh l  +dYDLC+ Cf++
  EFC37934.1 328 YSCNKCMD-KVRGFRYHKLDENDYDLCSLCFFA 359
                 9******9.**********************98 PP

>> C1_2  C1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1     0.092   4.1e+02      14      31 ..     161     178 ..     148     182 .. 0.77
   2 !   15.9  10.6   2.7e-06     0.012      11      46 ..     254     290 ..     205     291 .. 0.77
   3 !   10.3   4.3   0.00015      0.68       3      46 ..     313     356 ..     310     362 .. 0.81
   4 ?   -3.5   0.2       3.1   1.4e+04      22      35 ..     432     445 ..     421     447 .. 0.69

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.092
        C1_2  14 dssesfnCsaCgrkidgf 31 
                  ++  +nC+ C++ id++
  EFC37934.1 161 RRKRFHNCENCKEGIDDD 178
                 4566689****9988765 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 2.7e-06
        C1_2  11 kgedssesfnCsaCgrkidgffYsCseCd.fslhvrC 46 
                 ++e++  +f+C++C+++i+g +Y+C  Cd + l+  C
  EFC37934.1 254 EDEEELPEFSCDICEEPIHGIRYNCLDCDeYDLCGYC 290
                 45566667********************76**99988 PP

  == domain 3  score: 10.3 bits;  conditional E-value: 0.00015
        C1_2   3 HpHpLtlskgedssesfnCsaCgrkidgffYsCse.CdfslhvrC 46 
                 H+H+ + + ge++ ++++C+ C  k+ gf+Y+     d+ l++ C
  EFC37934.1 313 HDHTFQSV-GEEEFGTYSCNKCMDKVRGFRYHKLDeNDYDLCSLC 356
                 66777777.9********************996443677777777 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 3.1
        C1_2  22 saCgrkidgffYsC 35 
                 s+C   ++ +++ C
  EFC37934.1 432 SICNLVSNVERFCC 445
                 56777766666777 PP

>> DUF726  Protein of unknown function (DUF726)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   2.1e-05     0.096      68     171 ..     322     420 ..     315     426 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.1e-05
      DUF726  68 gAklsvkkmkkrvkeikdFefiplseqirlksltvtvsislelsdeddvtapwralakae.kdlYalkwEvelLkelGkaletilasealsvakqeilk 165
                   +++++  +k++ +++ F +  l e+        +++     +de+d+ +      ++  ++lY+   E+ lL+el + +e+i + +a++++k+e l+
  EFC37934.1 322 EEEFGTYSCNKCMDKVRGFRYHKLDENDYD---LCSLCFF--ATDEKDLFERIDLFGEKPvEELYTTFCEQLLLNELKTVMENISIVHAANTTKKE-LS 414
                 5578999******************99965...2334444..47888888887777655459*********************9988888888777.67 PP

      DUF726 166 rtvlas 171
                 +t ++ 
  EFC37934.1 415 STLISI 420
                 776665 PP

>> Sgf11  Sgf11 (transcriptional regulation protein)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.2    0.0087        39       3      11 ..     164     172 ..     162     176 .. 0.84
   2 ?    5.6   0.0    0.0026        12       3      19 ..     260     276 ..     258     277 .. 0.91
   3 ?    0.5   0.4       0.1   4.7e+02       5      19 ..     328     342 ..     327     342 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.0087
                 -EEE-TTTS CS
       Sgf11   3 eyvtCpnCg 11 
                 ++++C+nC+
  EFC37934.1 164 RFHNCENCK 172
                 6899****8 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0026
                 -EEE-TTTSSEEEGGGH CS
       Sgf11   3 eyvtCpnCgRqiaasRF 19 
                 + ++C++C+ +i++ R+
  EFC37934.1 260 PEFSCDICEEPIHGIRY 276
                 78***********9998 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.1
                 EE-TTTSSEEEGGGH CS
       Sgf11   5 vtCpnCgRqiaasRF 19 
                 ++C+ C+ ++ + R+
  EFC37934.1 328 YSCNKCMDKVRGFRY 342
                 689999988877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       886  (0.0494171); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 2824.61
//
Query:       EFC37935.1  [L=389]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.5e-32  109.7   1.1    1.2e-09   38.6   0.0    5.6  5  RCC1      Regulator of chromosome condensation (RCC1) repeat
    7.4e-14   51.1   4.6     0.0039   16.9   0.0    5.2  5  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
      0.003   17.7   0.1       0.16   12.3   0.0    3.0  3  DUF4213   Putative heavy-metal chelation


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0019        11      29      50 .]      73      96 ..      64      96 .. 0.81
   2 !   30.2   0.1   8.7e-11   5.2e-07       2      50 .]      99     147 ..      98     147 .. 0.89
   3 !   38.6   0.0     2e-13   1.2e-09       3      50 .]     152     202 ..     150     202 .. 0.93
   4 ?    3.1   0.0     0.026   1.5e+02       3      17 ..     214     228 ..     214     281 .. 0.53
   5 !   25.0   0.0   3.7e-09   2.2e-05       1      49 [.     284     332 ..     284     333 .. 0.93

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0019
                -GGGTTS..-EEEEEEETTEEEEE CS
        RCC1 29 veglsgn..rvvkvacGddhtval 50
                 ++++++   +v++++G+++t+++
  EFC37935.1 73 FSFFEERglYIVDIVSGAYFTFFI 96
                5677777789************97 PP

  == domain 2  score: 30.2 bits;  conditional E-value: 8.7e-11
                 TEEEEEE--GGGTTSSSS-...--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt...esvlvPtkveglsgnrvvkvacGddhtval 50 
                 + +y+ G n++GqLG g++   ++    +k+e+l+g +++k +cG +++++l
  EFC37935.1  99 DGIYGIGENENGQLGVGNNlnqND---FVKIESLNGLNIKKLVCGTFFSMVL 147
                 579****************75444...49********************986 PP

  == domain 3  score: 38.6 bits;  conditional E-value: 2e-13
                 EEEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt.esvlvPtkveglsgn..rvvkvacGddhtval 50 
                 +Vy++G n++GqLGlg + esvl+Ptk+e++ +   +   + cG + +++l
  EFC37935.1 152 EVYGFGLNHWGQLGLGYKsESVLLPTKLEMFGKGkiELETIYCGEHNVFFL 202
                 8*****************9999********9988899999******99986 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.026
                 EEEEEE--GGGTTSS CS
        RCC1   3 rVysWGrndyGqLGl 17 
                 ++y++G  ++GqL  
  EFC37935.1 214 QLYACGYMEFGQLTE 228
                 589999999999966 PP

  == domain 5  score: 25.0 bits;  conditional E-value: 3.7e-09
                 TTEEEEEE--GGGTTSSSS---EEEE.EE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvP.tkveglsgnrvvkvacGddhtva 49 
                 dG +y++G   +G LG+  ++++ +P t++++ +g+++ +++cG d t +
  EFC37935.1 284 DGCLYTFGTQRDGELGIDAKNDEVYPiTEIQW-KGDEIRSMTCGTDNTHF 332
                 8*******************9999**999999.678**********9965 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0   6.6e-07    0.0039       1      30 []      83     111 ..      83     111 .. 0.97
   2 !   16.7   0.0   7.8e-07    0.0047       1      29 [.     134     162 ..     134     163 .. 0.91
   3 ?    0.7   0.0      0.08   4.8e+02      20      30 .]     215     225 ..     212     225 .. 0.92
   4 !    9.3   0.0   0.00017      0.99       9      29 ..     276     296 ..     273     297 .. 0.90
   5 !    4.6   0.1     0.005        30       1      25 [.     320     344 ..     320     346 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 6.6e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++ +G+y+++++t+dG +++ G N++GQ
  EFC37935.1  83 IVDIVSGAYFTFFITNDG-IYGIGENENGQ 111
                 79****************.**********9 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 7.8e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 +k++ +G ++s++Lt d eV+++G N  G
  EFC37935.1 134 IKKLVCGTFFSMVLTQDSEVYGFGLNHWG 162
                 78999********************9755 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.08
      RCC1_2  20 VlcWGsNsdGQ 30 
                 ++++G  ++GQ
  EFC37935.1 215 LYACGYMEFGQ 225
                 8*********9 PP

  == domain 4  score: 9.3 bits;  conditional E-value: 0.00017
      RCC1_2   9 yHscaLtedGeVlcWGsNsdG 29 
                  +s+++t dG ++++G + dG
  EFC37935.1 276 GFSMIITQDGCLYTFGTQRDG 296
                 689*************99999 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.005
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGs 25 
                 ++s+ +G + + +Lt++G ++ +G+
  EFC37935.1 320 IRSMTCGTDNTHFLTNNGSIYNTGH 344
                 5678899999999********9995 PP

>> DUF4213  Putative heavy-metal chelation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.14   8.1e+02      11      42 ..      80     111 ..      77     120 .. 0.77
   2 !   12.3   0.0   2.6e-05      0.16       5      38 ..     126     169 ..     125     200 .. 0.75
   3 ?    0.3   0.0      0.14   8.6e+02      10      32 ..     264     286 ..     260     339 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.14
     DUF4213  11 dltVedvviGlnwtlVelsdggaGlAyteagk 42 
                 +l + d+v G+ +t   ++dg  G+  +e+g+
  EFC37935.1  80 GLYIVDIVSGAYFTFFITNDGIYGIGENENGQ 111
                 78899***************988887665555 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.6e-05
     DUF4213   5 ieaapedltVedvviGlnwtlVelsd...........ggaGlAyt 38 
                 ie++ ++l ++++v+G+++++V ++d           g++Gl y 
  EFC37935.1 126 IESL-NGLNIKKLVCGTFFSMVLTQDsevygfglnhwGQLGLGYK 169
                 5778.999******************6665555555555555554 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.14
     DUF4213  10 edltVedvviGlnwtlVelsdgg 32 
                 +++tV++ +  ++++++ ++dg+
  EFC37935.1 264 KEKTVKNMISSYGFSMIITQDGC 286
                 78899999999999999999953 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       547  (0.0305092); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2464.44
//
Query:       EFC37936.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1246  (0.0694963); expected 358.6 (0.02)
Passed bias filter:                      681  (0.0379832); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 2183.11
//
Query:       EFC37937.1  [L=489]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.1e-05   24.5  19.7        8.5    6.6   0.2    8.3  8  WW               WW domain
  ------ inclusion threshold ------
        1.1    9.5   4.5         14    5.9   0.8    3.0  3  PBCV_basic_adap  PBCV-specific basic adaptor domain


Domain annotation for each model (and alignments):
>> WW  WW domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.21   1.9e+03      14      19 ..      98     103 ..      93     103 .. 0.84
   2 ?    2.3   0.0     0.021   1.9e+02       8      21 ..     131     143 ..     128     146 .. 0.74
   3 !    5.7   0.0    0.0017        16       9      25 ..     150     166 ..     148     166 .. 0.89
   4 !    6.6   0.2   0.00095       8.5      11      24 ..     180     192 ..     177     194 .. 0.77
   5 !    3.7   0.2    0.0075        67       9      18 ..     337     345 ..     336     349 .. 0.80
   6 !    4.9   0.1     0.003        27      11      25 ..     357     371 ..     352     372 .. 0.78
   7 !    4.3   0.2    0.0047        42       9      20 ..     404     414 ..     402     415 .. 0.82
   8 ?    3.0   0.0     0.012   1.1e+02      12      24 ..     464     475 ..     461     477 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.21
                 T-EEEE CS
          WW  14 GrvYYy 19 
                 Gr++Y+
  EFC37937.1  98 GRPFYV 103
                 9****8 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.021
                 EE-TTTT-EEEEET CS
          WW   8 qwdpdsGrvYYyNh 21 
                  +d + +r Y++++
  EFC37937.1 131 LTDNK-NRRYFVDS 143
                 45556.******97 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0017
                 E-TTTT-EEEEETTT-- CS
          WW   9 wdpdsGrvYYyNheTge 25 
                  d+++G ++Y++ +++e
  EFC37937.1 150 MDAKTGLPFYIDNNNKE 166
                 69999********9997 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.00095
                 TTTT-EEEEETTT- CS
          WW  11 pdsGrvYYyNheTg 24 
                 +  Gr+YY++ +Tg
  EFC37937.1 180 SL-GRYYYIDGKTG 192
                 33.******98886 PP

  == domain 5  score: 3.7 bits;  conditional E-value: 0.0075
                 E-TTTT-EEE CS
          WW   9 wdpdsGrvYY 18 
                 +d++ GrvYY
  EFC37937.1 337 VDSQ-GRVYY 345
                 6888.***** PP

  == domain 6  score: 4.9 bits;  conditional E-value: 0.003
                 TTTT-EEEEETTT-- CS
          WW  11 pdsGrvYYyNheTge 25 
                 +++G  YY+++  g+
  EFC37937.1 357 SETGESYYIDPVSGQ 371
                 566******998876 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.0047
                 E-TTTT-EEEEE CS
          WW   9 wdpdsGrvYYyN 20 
                 ++++ +++YYyN
  EFC37937.1 404 STSR-KKTYYYN 414
                 5677.99****9 PP

  == domain 8  score: 3.0 bits;  conditional E-value: 0.012
                 TTT-EEEEETTT- CS
          WW  12 dsGrvYYyNheTg 24 
                 d G+ Y+++++Tg
  EFC37937.1 464 D-GKMYWIDENTG 475
                 5.99********7 PP

>> PBCV_basic_adap  PBCV-specific basic adaptor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1       1.7   1.5e+04       4      18 ..     133     147 ..     133     148 .. 0.67
   2 ?    5.9   0.8    0.0016        14       3      26 ..     169     190 ..     169     197 .. 0.84
   3 ?    3.7   0.0    0.0074        67       3      16 ..     337     350 ..     335     354 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 1.7
  PBCV_basic_adap   4 DaKGRivfkgprGgk 18 
                      D K R+ f ++ G +
       EFC37937.1 133 DNKNRRYFVDSQGNA 147
                      557777777777765 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0016
  PBCV_basic_adap   3 vDaKGRivfkgprGgkyVkdsnGK 26 
                      vD+  Ri f+++ G+ y +d  GK
       EFC37937.1 169 VDSYDRIFFRDSLGRYYYID--GK 190
                      89999**********99887..43 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.0074
  PBCV_basic_adap   3 vDaKGRivfkgprG 16 
                      vD+ GR  +k+  G
       EFC37937.1 337 VDSQGRVYYKDQNG 350
                      89999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       809  (0.0451224); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.46
# Mc/sec: 3198.07
//
Query:       EFC37938.1  [L=310]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.9e-20   72.4   0.2    4.8e-20   72.1   0.2    1.1  1  NmrA             NmrA-like family
      7e-15   55.4   0.0    9.2e-15   55.0   0.0    1.3  1  NAD_binding_10   NAD(P)H-binding
    0.00021   20.5   0.1    0.00045   19.4   0.1    1.5  2  Polysacc_synt_2  Polysaccharide biosynthesis protein
     0.0016   17.6   0.0        0.9    8.6   0.0    2.4  2  RmlD_sub_bind    RmlD substrate binding domain
      0.003   18.0   0.0     0.0056   17.1   0.0    1.6  1  Semialdhyde_dh   Semialdehyde dehydrogenase, NAD binding doma
     0.0055   15.9   0.3       0.16   11.1   0.0    2.3  2  NAD_binding_4    Male sterility protein
  ------ inclusion threshold ------
      0.025   14.1   0.0      0.039   13.5   0.0    1.4  1  DUF676           Putative serine esterase (DUF676)
      0.032   15.0   0.1      0.068   13.9   0.1    1.6  1  DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomer
      0.034   13.3   0.1      0.046   12.8   0.1    1.3  1  ABC2_membrane_3  ABC-2 family transporter protein
      0.035   13.5   0.0        1.1    8.5   0.0    2.6  3  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
       0.15   11.5   0.0       0.47    9.9   0.0    1.9  1  Epimerase        NAD dependent epimerase/dehydratase family


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.1   0.2   2.9e-23   4.8e-20       1     232 [.       5     243 ..       5     244 .. 0.84

  Alignments for each domain:
  == domain 1  score: 72.1 bits;  conditional E-value: 2.9e-23
                 EEESSTTSHHHHHHHHHHHH....HT-EEEEEES-S..-SHHHHHHHHSTTEEEES-TT-HHHHHHHHTT-SEEEE---GG..S-HHHHHHHHHHHHHH CS
        NmrA   1 IlviGaTGrqGksvvrallk....aghkvralvRdt..kselakslkeaGvelvkgdlddkeslvealkgvdvvfsvtgfy..skeiedgkklvdAake 91 
                 I ++GaTG++G+ ++r+l +     + k + lvR++    +l ++  +   e v g+ +  +sl +++++v+ +f+vt ++   +++e ++   ++   
  EFC37938.1   5 IFITGATGNIGSELIRILNSspteTKLKLKLLVRNVekAYKLFEECTNLDIEYVLGEFETISSLPTIFQDVERIFFVTIATpnVAQLERQVVELAVKTS 103
                 789**************98877779999********5445789************************************88655555555555555555 PP

                 HS-SEEE.EEE---GG.GT.SSS---TTTHHHHHHHHHHHHCTS-EEEEEE-EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE....-HHHH CS
        NmrA  92 aGvkhfi.ySslgddndrsnaeepavphfdsKaeieeyvralgipytfvyagffmenflsllaqlkvgdtappedkvtllgpgnpkavll....daeeD 185
                  G k+++  S lg+  d  + ++  ++++ds  ++++++++ +i y  +++++f +n+ +       gd+a  +++ ++ +p + ++ +     ++++D
  EFC37938.1 104 KGLKQVVkISALGASGDLEQNNF-FKNLHDSETSVRKALKNTSISYVVIRPNMFIQNYVR-------GDLADIKNSGVFYRPKHDHGLPYrishVDTRD 194
                 67999995688999998887777.9*********************************99.......3444444566788888877777778899**** PP

                 HHHHHHHHHHH.HHHHTTEEEEE-S.EEE-HHHHHHHHHHHHTS-EEEE CS
        NmrA 186 iGafvikilkd.prklkgkriklag.ntlsgneivelfekkigktvkYt 232
                 i ++v++il + p++  ++ ++l+g + l++++++++++k +gk++k++
  EFC37938.1 195 ISEMVAQILIQpPEQHANQTYNLTGpQSLTYEQVAQIISKSLGKEIKFV 243
                 *********9966666666666655389*******************97 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.0   0.0   5.7e-18   9.2e-15       1     149 [.       9     159 ..       9     206 .. 0.86

  Alignments for each domain:
  == domain 1  score: 55.0 bits;  conditional E-value: 5.7e-18
                     TTTSHHHHHHHHHHHHC-...T-EEEEEETTHHHCHHHH...CTTTCEEEE--TT-CCHHHHHHTT-SEEEES---TCCHHHHHHHHHHHHHH.. CS
  NAD_binding_10   1 GAtGkvGrllvkellarg...ghevtalvRnpeklaele...aeeglevvegdvtdvedlaealkgadaVvsalggggkdeegaknivdaake.. 87 
                     GAtG++G++l++ l ++    ++++++lvRn ek+ +l     +  +e v g++++ ++l   +++++ +++ + ++ + ++  +++v+ a +  
      EFC37938.1   9 GATGNIGSELIRILNSSPtetKLKLKLLVRNVEKAYKLFeecTNLDIEYVLGEFETISSLPTIFQDVERIFFVTIATPNVAQLERQVVELAVKts 103
                     9***********9999989889999**********87762333467789******************************9********9776534 PP

                     CT--EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEEEEEEE-CEE-S CS
  NAD_binding_10  88 agvkRfvlvsaigvgdevpgefgewnkellkaylaakraaeellrasgldwTivrpggLtde 149
                     +g k++v +sa+g+     g++++  ++++k+ ++  +   + l+++ + ++++rp ++ ++
      EFC37938.1 104 KGLKQVVKISALGAS----GDLEQ--NNFFKNLHDSETSVRKALKNTSISYVVIRPNMFIQN 159
                     89************9....55554..6899***************************99776 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.1   2.8e-07   0.00045       1     114 [.       5     112 ..       5     117 .. 0.75
   2 ?   -3.5   0.0       2.7   4.4e+03      96     125 ..     274     303 ..     268     308 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.8e-07
                      EEEETTTSHHHHHHHHHHHHH...B-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT..T-SEEEE.------H CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkk...kpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrdkerlekaleelkvdvvfh.aAAlKhV 90 
                      +++tGa+G iGsel+r + ++   +  k+ ll r+  k y++ +e+        ++++i  v+g+ +  ++l ++++  +v+ +f  + A+ +V
       EFC37938.1   5 IFITGATGNIGSELIRILNSSpteTKLKLKLLVRNVEKAYKLFEEC--------TNLDIEYVLGEFETISSLPTIFQ--DVERIFFvTIATPNV 88 
                      78*************8665554323335666666666666666665........23455688***************..8887776156999** PP

                      HHHHHSHHHHHHHHHHHHHHHHHH CS
  Polysacc_synt_2  91 PlveenpleaiktNvlgtenviea 114
                        +e++++e       g ++v+++
       EFC37938.1  89 AQLERQVVELAVKTSKGLKQVVKI 112
                      ******999877777888888776 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.7
                      SHHHHHHHHHHHHHHHHHHHHHTT-SEEEE CS
  Polysacc_synt_2  96 npleaiktNvlgtenvieaaieagvkkvvl 125
                      + l++ + Nv+g  ++i+  +   v+++  
       EFC37938.1 274 FKLNGTTANVHGDYQLITGKKPRSVEEFFN 303
                      566778899999999998888888888765 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0   0.00055       0.9       2      24 ..       4      26 ..       3      51 .. 0.85
   2 !    6.6   0.0    0.0023       3.7     186     234 ..     192     239 ..     188     250 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00055
                   EEEEESTTSHHHHHHHHHCTTTS CS
  RmlD_sub_bind  2 kilvtGanGqlGseLakqlaeeg 24
                   ki +tGa+G +GseL++ l+++ 
     EFC37938.1  4 KIFITGATGNIGSELIRILNSSP 26
                   799**************998765 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0023
                    HHHHHHHHHHHHHHCHH.GGG-EEEE---BS-EEHHHHHHHHHHHHCHT CS
  RmlD_sub_bind 186 ardlAevllqllekaaeekelagvyHlanegetswlefArailkeagad 234
                    +rd++e+++q+l +  e ++++++y l++ ++++  ++A+ i k++g++
     EFC37938.1 192 TRDISEMVAQILIQPPE-QHANQTYNLTGPQSLTYEQVAQIISKSLGKE 239
                    89***********9997.7779********************9998874 PP

>> Semialdhyde_dh  Semialdehyde dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.0   3.4e-06    0.0056       1      46 [.       4      52 ..       4     114 .. 0.64

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3.4e-06
                    EEEEETTTSHHHHHHHHHHHC...TSSEEEEEEEESTTTTTSBHHHHSG CS
  Semialdhyde_dh  1 kvaivGatGyvGqellrlLee...hpevelvvllsssrsaGkklaeavk 46
                    k+ i GatG++G+el+r+L++   + +++l  l+ + ++a k ++e  +
      EFC37938.1  4 KIFITGATGNIGSELIRILNSsptETKLKLKLLVRNVEKAYKLFEECTN 52
                    57799****************4444456666666666655554444444 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.0   9.6e-05      0.16       1      34 [.       7      42 ..       7      81 .. 0.82
   2 ?    2.7   0.0     0.036        59     181     213 ..     131     163 ..      72     176 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 9.6e-05
                   EE-TTSHHHHHHHHHHHHHS-.T..EEEEEE-SSSH CS
  NAD_binding_4  1 lTGaTGFLGkvLlekLLrttpev..kiyllvRaksg 34
                   +TGaTG +G+ L++ L ++ +e   k+ llvR+ ++
     EFC37938.1  7 ITGATGNIGSELIRILNSSPTETklKLKLLVRNVEK 42
                   8************999988888878999****8765 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.036
                    HHHHHHHHHHHHHH---EEEEEE-EEE--SSST CS
  NAD_binding_4 181 alaEklvrearrrsglpvvivRpsiitgesktG 213
                    + +E  vr+a ++  +  v++Rp + + + + G
     EFC37938.1 131 HDSETSVRKALKNTSISYVVIRPNMFIQNYVRG 163
                    446888888888888888888888877765555 PP

>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   2.4e-05     0.039     107     163 ..      68     121 ..      51     187 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.4e-05
      DUF676 107 lkeaikglepvtfitlasPhLGvlysskslinlglalleklkkslsmeqlgltGrdL 163
                 l+++++++e ++f+t+a+P +  l ++   ++l ++  + lk++ ++ +lg +G dL
  EFC37938.1  68 LPTIFQDVERIFFVTIATPNVAQLERQV--VELAVKTSKGLKQVVKISALGASG-DL 121
                 56789**************987765555..599999****************96.22 PP

>> DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   4.2e-05     0.068       1     107 [.       5     109 ..       5     121 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 4.2e-05
                      EEEESTTSHHHHHHHHHHHHCTTTEEEEEEEESSTHHHHHHHHHH...HT-SEEEESSHHHHHHHHHHHHHTTSSSEEEESHHHHHHHHCHTT- CS
  DXP_reductoisom   1 vviLGsTGSIGtqtLdvieenpdkfevvalaagsnvellaeqake...fkpklvavadeeaaeelkealkekelktevlvGeealkelaeeeea 91 
                      + i G+TG IG++ + ++++ p + ++      +nve+++++ +e   + +++v   + e+ ++l + +++     ++++ + a  ++a+  e 
       EFC37938.1   5 IFITGATGNIGSELIRILNSSPTETKLKLKLLVRNVEKAYKLFEEctnLDIEYVL-GEFETISSLPTIFQD---VERIFFVTIATPNVAQ-LER 93 
                      6799*****************9877776666666776666655541005555554.334455555555533...3345555555555555.445 PP

                      SEEEE--SSGGGHHHH CS
  DXP_reductoisom  92 dvvvaaivGaaGLkpt 107
                      +vv  a+  + GLk  
       EFC37938.1  94 QVVELAVKTSKGLKQV 109
                      6666677777777665 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   2.8e-05     0.046      50     111 ..     113     221 ..      61     274 .. 0.65

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.8e-05
  ABC2_membrane_3  50 ealeaspsve....lvyevdseeeakkalkngdidgilvipkgfskdll...........................................kg 96 
                      +al as+++e      +  dse++ +kalkn+ i+++++ p+ f+++ +                                           + 
       EFC37938.1 113 SALGASGDLEqnnfFKNLHDSETSVRKALKNTSISYVVIRPNMFIQNYVrgdladiknsgvfyrpkhdhglpyrishvdtrdisemvaqiliQP 206
                      5555555555555555999***************************988888888777777777555555555555555555555555555533 PP

  ABC2_membrane_3  97 esatvtvlinssnln 111
                       +++++ ++n ++++
       EFC37938.1 207 PEQHANQTYNLTGPQ 221
                      333333333333333 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0   0.00069       1.1       1      74 [.       6      75 ..       6      79 .. 0.70
   2 ?    1.5   0.0     0.096   1.6e+02     183     207 ..     181     205 ..     167     218 .. 0.87
   3 ?   -0.5   0.0       0.4   6.5e+02     227     277 ..     193     247 ..     188     256 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00069
                   EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHH CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaev 74
                   +iTG +G iGs l++ L +   e       + ++ ++++e+ +k  +e+++ +++ + g+ +  ssl  ++++v
     EFC37938.1  6 FITGATGNIGSELIRILNSSPTETKL----KLKLLVRNVEKAYKLFEECTNLDIEYVLGEFETISSLPTIFQDV 75
                   69***************998777632....33334556666666555566667777777777777777777766 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.096
                    EESTTS-TTSCCCHHHHHHHHHHTT CS
  GDP_Man_Dehyd 183 hesprrgetfvtrkitravarialg 207
                    h  p+r  ++ tr i+++va+i+ +
     EFC37938.1 181 HGLPYRISHVDTRDISEMVAQILIQ 205
                    5669*****************9876 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.4
                    HHHHHHHHHHH....HCSS---EEE-TT-EEECHHCHHCCHHCCCHHHHHH.... CS
  GDP_Man_Dehyd 227 kDyveamwlml....qqdkpedyviatgethsvrefvelaflelgktiewegkge 277
                    +D+ e++ ++l    +q  +++y++   ++ + ++++++  ++lgk+i++ + +e
     EFC37938.1 193 RDISEMVAQILiqppEQHANQTYNLTGPQSLTYEQVAQIISKSLGKEIKFVELDE 247
                    5666666666632223455677777777888888888888888888888766555 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00029      0.47       1      24 [.       5      28 ..       5      78 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00029
                EEEETTTSHHHHHHHHHHHHCTSE CS
   Epimerase  1 ilVtGatGfiGsalvkallekgye 24
                i++tGatG iGs l++ l++   e
  EFC37938.1  5 IFITGATGNIGSELIRILNSSPTE 28
                79****************998855 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       656  (0.0365888); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 1894.49
//
Query:       EFC37939.1  [L=285]
Description: leucine-rich repeat protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-21   74.5  10.2    0.00032   20.5   0.1    7.4  7  LRR_6       Leucine Rich repeat
    2.1e-19   69.3  10.9    2.2e-05   24.7   0.1    4.7  4  LRR_4       Leucine Rich repeats (2 copies)
    2.7e-19   68.7  13.2    4.5e-10   39.1   2.7    4.0  4  LRR_8       Leucine rich repeat
    6.3e-11   41.2   6.2        3.5    8.5   0.1    7.3  7  LRR_1       Leucine Rich Repeat
    4.5e-05   23.0   3.6     0.0041   16.7   0.5    2.2  2  LRR_9       Leucine-rich repeat
     0.0077   16.1   0.2      0.019   14.8   0.2    1.8  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.021   14.7   0.1      0.042   13.7   0.1    1.5  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   0.1    0.0058        15       4      15 ..     122     133 ..     120     134 .. 0.86
   2 !   12.5   0.0   4.5e-05      0.12       4      24 .]     147     167 ..     145     167 .. 0.89
   3 !   20.5   0.1   1.2e-07   0.00032       3      24 .]     170     191 ..     168     191 .. 0.93
   4 !    9.0   0.0   0.00062       1.6       4      22 ..     195     213 ..     192     215 .. 0.84
   5 ?    3.6   0.0     0.032        83       5      23 ..     220     238 ..     217     238 .. 0.89
   6 !   14.8   0.1   8.3e-06     0.021       5      23 ..     244     262 ..     240     262 .. 0.91
   7 !    8.0   0.0    0.0013       3.3       4      16 ..     267     279 ..     264     280 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0058
       LRR_6   4 hLteLdLsgNdI 15 
                 hLt Ld+s N +
  EFC37939.1 122 HLTQLDVSVNLF 133
                 9********976 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 4.5e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt L++s+N Ig  Ga+ ++
  EFC37939.1 147 QLTNLNISHNTIGVYGAKHIS 167
                 69***********99999885 PP

  == domain 3  score: 20.5 bits;  conditional E-value: 1.2e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  hLt L++sgN Ig +Ga+a++
  EFC37939.1 170 KHLTILNISGNLIGQQGAKAIS 191
                 6*******************96 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00062
       LRR_6   4 hLteLdLsgNdIgDeGaea 22 
                 +LteL++s N I  eG++ 
  EFC37939.1 195 YLTELNISNNSIFEEGVKF 213
                 7**********98888875 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.032
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++Ld+  N I  +G+e L
  EFC37939.1 220 LRTLDIHNNMIEEKGVEHL 238
                 99****9999*99999986 PP

  == domain 6  score: 14.8 bits;  conditional E-value: 8.3e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+s N Ig  G++ L
  EFC37939.1 244 LTKLDISNNSIGANGVKYL 262
                 9***************976 PP

  == domain 7  score: 8.0 bits;  conditional E-value: 0.0013
       LRR_6   4 hLteLdLsgNdIg 16 
                  Lt Ld+s+N I+
  EFC37939.1 267 QLTILDVSYNRID 279
                 59********996 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.1     0.041   1.1e+02      21      33 ..     118     131 ..      92     138 .. 0.75
   2 !   24.1   0.3   1.3e-08   3.4e-05       1      36 [.     146     182 ..     146     195 .. 0.89
   3 !   21.4   0.2   9.6e-08   0.00025       3      37 ..     196     231 ..     196     241 .. 0.87
   4 !   24.7   0.1   8.7e-09   2.2e-05       2      36 ..     243     278 ..     242     282 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.041
                 H.-TT--EEE-.-S CS
       LRR_4  21 k.lpnLkeLdLsgN 33 
                 + +++L++Ld+s N
  EFC37939.1 118 GlMKHLTQLDVSVN 131
                 44999*****9655 PP

  == domain 2  score: 24.1 bits;  conditional E-value: 1.3e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 p+L++L++s+N +   +   ++kl++L+ L++sgN li
  EFC37939.1 146 PQLTNLNISHNTIGVYGAkhISKLKHLTILNISGN-LI 182
                 78*************99998778***********9.77 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 9.6e-08
                 --EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   3 LevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 L++L++snN + + +  + + +++L++Ld+ +Nn i+
  EFC37939.1 196 LTELNISNNSIFEEGVkFIGeMKQLRTLDI-HNNMIE 231
                 99********99888896666*********.887875 PP

  == domain 4  score: 24.7 bits;  conditional E-value: 8.7e-09
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++Ld+snN +   +   l k+++L+ Ld+s N +i
  EFC37939.1 243 QLTKLDISNNSIGANGVkyLTKMKQLTILDVSYN-RI 278
                 7************99999999**********999.54 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.045   1.2e+02      21      39 ..     117     135 ..     112     145 .. 0.72
   2 !   39.1   2.7   1.8e-13   4.5e-10       1      61 []     146     206 ..     146     206 .. 0.98
   3 !   23.9   0.5     1e-08   2.6e-05      22      61 .]     215     254 ..     209     254 .. 0.87
   4 !   21.1   0.1   7.4e-08   0.00019       2      38 ..     243     279 ..     242     282 .. 0.94

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.045
                 STT-TT--EEE--SS---G CS
       LRR_8  21 FkglsnLkvLdLsnNlltt 39 
                 F  +++L+ Ld s Nl t+
  EFC37939.1 117 FGLMKHLTQLDVSVNLFTF 135
                 5557778888877777665 PP

  == domain 2  score: 39.1 bits;  conditional E-value: 1.8e-13
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 p+Lt+L++s+N + + + +  ++l++L++L++s Nl+    ++a+s+L+ L++L++s+N +
  EFC37939.1 146 PQLTNLNISHNTIGVYGAKHISKLKHLTILNISGNLIGQQGAKAISNLEYLTELNISNNSI 206
                 79*********************************************************87 PP

  == domain 3  score: 23.9 bits;  conditional E-value: 1e-08
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                   +++L++Ld+ nN ++    + + +L++L++Ld+s+N +
  EFC37939.1 215 GEMKQLRTLDIHNNMIEEKGVEHLTQLEQLTKLDISNNSI 254
                 4499999999999999999999999999999999999986 PP

  == domain 4  score: 21.1 bits;  conditional E-value: 7.4e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 +Lt+Ld+snN++ + + +  +++++L++Ld s+N+++
  EFC37939.1 243 QLTKLDISNNSIGANGVKYLTKMKQLTILDVSYNRID 279
                 79********************************997 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.6   4.2e+03       1      12 [.     122     133 ..     122     144 .. 0.76
   2 ?    4.2   0.0     0.035        90       2      23 .]     148     169 ..     147     169 .. 0.80
   3 !    8.5   0.1    0.0014       3.5       1      23 []     171     193 ..     168     193 .. 0.87
   4 !    7.6   0.0    0.0027         7       2      14 ..     196     208 ..     195     216 .. 0.82
   5 !    6.2   0.0    0.0078        20       1      20 [.     219     238 ..     219     241 .. 0.80
   6 !    6.9   0.0    0.0046        12       1      12 [.     243     254 ..     243     263 .. 0.84
   7 ?    3.4   0.0     0.065   1.7e+02       1      12 [.     267     278 ..     267     283 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.6
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+ Ld+s n +
  EFC37939.1 122 HLTQLDVSVNLF 133
                 58899*999977 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.035
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ L++s+n ++  ++ ++++L
  EFC37939.1 148 LTNLNISHNTIGVYGAKHISKL 169
                 899******9987777777765 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0014
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L+ L++s+n +++ ++ +++nL
  EFC37939.1 171 HLTILNISGNLIGQQGAKAISNL 193
                 57888*******99999999987 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.0027
       LRR_1   2 LrhLdLsnnpllg 14 
                 L++L++snn+++ 
  EFC37939.1 196 LTELNISNNSIFE 208
                 99********964 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.0078
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr+Ld+ nn ++ ++ +++
  EFC37939.1 219 QLRTLDIHNNMIEEKGVEHL 238
                 59********9977776665 PP

  == domain 6  score: 6.9 bits;  conditional E-value: 0.0046
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+snn++
  EFC37939.1 243 QLTKLDISNNSI 254
                 599*******97 PP

  == domain 7  score: 3.4 bits;  conditional E-value: 0.065
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+ Ld+s+n++
  EFC37939.1 267 QLTILDVSYNRI 278
                 599*******98 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.1    0.0014       3.5      59     125 ..     116     182 ..      87     190 .. 0.81
   2 !   16.7   0.5   1.6e-06    0.0041      63     153 ..     193     281 ..     187     284 .. 0.73

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0014
       LRR_9  59 gfPllkrlktlllnnnrivr.iaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                  f l+k l  l ++ n  +   a+ ++e  P+l++l +++n++   +  + + +lk+l++l +  n +
  EFC37939.1 116 LFGLMKHLTQLDVSVNLFTFsQAKLIGELAPQLTNLNISHNTIGVYGA-KHISKLKHLTILNISGNLI 182
                 478899999999999987651456679****************99988.8999999999999987766 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 1.6e-06
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld..frkvklk 153
                 l+ l  l ++nn i   + ++   + +l++l + nn+++e + ++ l++l++l+ l + +n++ ++    +y + k+kql++ld  ++++ +k
  EFC37939.1 193 LEYLTELNISNNSIFEEGVKFIGEMKQLRTLDIHNNMIEEKG-VEHLTQLEQLTKLDISNNSIGANG--VKY-LTKMKQLTILDvsYNRIDEK 281
                 566777888899998888888888889999999998888865.589999999999999888887653..233.46888888888334455444 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.2   7.6e-06     0.019       2      39 ..      35      75 ..      34      84 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 7.6e-06
                HHHHS-HHHHHHHHHTS-HHH....HHHHCTT-HHHHHHHTT CS
       F-box  2 tlsrLPsevlrhILerLplsd....llalrrVSkgwrilids 39
                ++   +++v+ +IL +    d    + ++++VSk w ++i +
  EFC37939.1 35 PFEIFSDDVIYEILNY-HRNDfifmVMNCALVSKQWLNVISE 75
                6677899*********.7777*****************9976 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   1.7e-05     0.042       6      36 ..      41      74 ..      41      83 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.7e-05
  F-box-like  6 dEiLlqIFsyLppsd....LlrlalVCrrWrrval 36
                d+++ +I+ y + +d      ++alV+++W +v++
  EFC37939.1 41 DDVIYEILNY-HRNDfifmVMNCALVSKQWLNVIS 74
                5778888988.4555555599************94 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1780.57
//
Query:       EFC37940.1  [L=141]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-29  101.8   0.3    4.2e-29  101.7   0.3    1.0  1  14-3-3    14-3-3 protein


Domain annotation for each model (and alignments):
>> 14-3-3  14-3-3 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.7   0.3   2.3e-33   4.2e-29      94     222 .]       2     130 ..       1     130 [. 0.91

  Alignments for each domain:
  == domain 1  score: 101.7 bits;  conditional E-value: 2.3e-33
                 HHHCCHCH.-SHHHHHHHHHHHHHHHHHHHCC--HHHHHHH.HHHHHHHHHHHHHHHHTTTGCC-HHHHHHHHHHHHHHHCTT--HHHHHHHHHHHHHC CS
      14-3-3  94 ldktlipkatseeskvfylkmkgDyyRYlaEfaegeekkea.aekakeaYeeAleiakkelqpthpirLglaLNySVflyeilnspekAcelakkafde 191
                 +d++l  k  ++++ vfy ++kgD+yR++  ++ +++k+e  +ek+ ++Ye+ +e+  k+l+ ++p+rL+l++   V++ ++l++++kA+e+a+++fd+
  EFC37940.1   2 IDRILKVKGLTDQELVFYAQLKGDFYRHVLTVDPESAKDELlKEKCLNSYESGIETI-KSLSIVDPTRLSLIISLVVYYSDVLKDKKKAIEMAQSEFDK 99 
                 566666445778899******************99877775167899*********9.89*************************************** PP

                 CHCCCCCS.TTTHHHHHHHHHHHHHHHHHHC CS
      14-3-3 192 aiaeldelseesykdstlilqlLrdnltlWt 222
                 ai e+d ls+e y+++ l+lq+L+dn+ +W+
  EFC37940.1 100 AIPEVDYLSDEWYREAILLLQILKDNIIMWS 130
                 ******************************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 891.64
//
Query:       EFC37941.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       654  (0.0364772); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.25s 00:00:00.70 Elapsed: 00:00:00.43
# Mc/sec: 1628.38
//
Query:       EFC37942.1  [L=1112]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-11   43.4   0.0    1.4e-10   41.6   0.0    2.0  1  AlbA_2    Putative DNA-binding domain
    5.1e-05   23.5   0.1    0.00017   21.9   0.1    1.9  1  BTB_2     BTB/POZ domain


Domain annotation for each model (and alignments):
>> AlbA_2  Putative DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.6   0.0   1.5e-14   1.4e-10      22      99 ..     284     370 ..     264     390 .. 0.80

  Alignments for each domain:
  == domain 1  score: 41.6 bits;  conditional E-value: 1.5e-14
      AlbA_2  22 iakticAfaNsegGtlliGVeDdgkvvGvecsdqeedqlrlelksiikrfkpkvlpdi...ervelkgk......kvlvvkvekskk 99 
                 + ++++A +Ns+gG l++GV Ddg v G++ s++++d+ rl  +++i++f+ ++ p++   +r+e+k++      ++++++v+ks+ 
  EFC37942.1 284 MTEYLIAYLNSNGGALIFGVRDDGVVMGMKLSEKQRDKIRLMFDNCIRNFQITPAPRVaihYRLEFKKTtnvpslWIMILEVKKSDF 370
                 899*********************************************998874444311245666666777777999999998875 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.1   1.9e-08   0.00017      38      89 ..     490     539 ..     456     542 .. 0.77

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 1.9e-08
                 ETTTTEEEE-S-HHHHHHHHHHHHS.S-B---TTS-HHHHHHHHHHHT--TT CS
       BTB_2  38 deetneyffDRspklFetiLnyyrtggkLhrpeevelkslleElefygleel 89 
                  +e++++++DR +k+F+ i ++++  g + ++   +   ++ E+e+ygl el
  EFC37942.1 490 MDEQGRFLVDRPSKFFKLIYQFLQI-GYVSVK-MYDWAVFKLEAEYYGLAEL 539
                 567899*******************.555554.5799************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1112 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       980  (0.05466); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.88u 0.31s 00:00:01.19 Elapsed: 00:00:00.51
# Mc/sec: 6536.62
//
Query:       EFC37943.1  [L=402]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-30  102.3  22.3     0.0033   17.4   0.0   10.6 10  LRR_6           Leucine Rich repeat
    3.9e-25   87.4  22.3    3.8e-10   39.4   1.0    5.0  5  LRR_8           Leucine rich repeat
    1.1e-16   60.6  42.0    0.00022   21.5   0.6    8.0 11  LRR_4           Leucine Rich repeats (2 copies)
    5.4e-09   35.4  16.1        9.4    7.2   0.0   10.3  9  LRR_1           Leucine Rich Repeat
    4.8e-05   22.9  12.3      0.082   12.4   2.8    3.6  4  LRR_9           Leucine-rich repeat
     0.0022   17.8   0.0     0.0047   16.8   0.0    1.4  1  F-box-like      F-box-like
  ------ inclusion threshold ------
      0.036   13.8   0.3         12    5.7   0.0    4.0  4  Spore_YhaL      Sporulation protein YhaL
      0.064   13.2   0.1       0.17   11.8   0.1    1.7  1  F-box           F-box domain
      0.074   13.2   0.0         15    5.8   0.0    2.9  2  YmcE_antitoxin  Putative antitoxin of bacterial toxin-antitox
       0.29   10.6   8.1        1.3    8.5   0.2    3.8  4  RNA_pol_I_TF    RNA polymerase I specific initiation factor
        1.7    9.0   4.1         29    5.0   0.2    3.3  3  DUF1462         Protein of unknown function (DUF1462)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0     2e-06    0.0033       3      24 .]     128     149 ..     127     149 .. 0.92
   2 !   12.1   0.1   9.7e-05      0.16       5      23 ..     154     172 ..     151     173 .. 0.90
   3 !   15.3   0.0   8.9e-06     0.015       4      23 ..     177     196 ..     174     197 .. 0.89
   4 !   11.7   0.1   0.00013      0.21       5      23 ..     202     220 ..     199     220 .. 0.90
   5 !    7.1   0.0     0.004       6.6       2      24 .]     223     245 ..     222     245 .. 0.90
   6 !   11.0   0.1   0.00022      0.36       7      24 .]     252     269 ..     248     269 .. 0.88
   7 !    8.8   0.1    0.0011       1.8       5      17 ..     274     286 ..     271     287 .. 0.92
   8 ?    2.5   0.0      0.11   1.8e+02       3      20 ..     297     314 ..     295     318 .. 0.80
   9 !   14.5   0.1   1.7e-05     0.028       3      24 .]     321     342 ..     319     342 .. 0.89
  10 !    8.8   0.1    0.0012       1.9       3      24 .]     345     366 ..     343     366 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 2e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt+L +s N+I ++Ga+ ++
  EFC37943.1 128 KSLTTLYISRNNIENDGAKHIS 149
                 58*****************986 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 9.7e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++s+N+I  eGa+ +
  EFC37943.1 154 LTLLNISSNNIEEEGAKYI 172
                 899*************977 PP

  == domain 3  score: 15.3 bits;  conditional E-value: 8.9e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt+Ld+s NdI   Ga  +
  EFC37943.1 177 KLTYLDISKNDIRSNGALYI 196
                 8***************9876 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 0.00013
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L +s+N+I+ eGa  L
  EFC37943.1 202 LTSLVISSNNIDEEGAAHL 220
                 9**************9765 PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.004
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  t+LteL+   N++g eGa+ ++
  EFC37943.1 223 LTNLTELETVRNEFGAEGAKHIS 245
                 589999999***********986 PP

  == domain 6  score: 11.0 bits;  conditional E-value: 0.00022
       LRR_6   7 eLdLsgNdIgDeGaeaLa 24 
                  L++++N IgDeGa+ ++
  EFC37943.1 252 NLNINDNFIGDEGAKYIS 269
                 69************9885 PP

  == domain 7  score: 8.8 bits;  conditional E-value: 0.0011
       LRR_6   5 LteLdLsgNdIgD 17 
                 Lt L++ +N+I+D
  EFC37943.1 274 LTILNIGSNEITD 286
                 9***********9 PP

  == domain 8  score: 2.5 bits;  conditional E-value: 0.11
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                 + LteL + +N I+   +
  EFC37943.1 297 NQLTELYIEDNSIQTNAC 314
                 579**********97655 PP

  == domain 9  score: 14.5 bits;  conditional E-value: 1.7e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L  Ld+sgN+++ eGa+ ++
  EFC37943.1 321 QNLNLLDISGNNVDAEGAKYIS 342
                 78999*************9885 PP

  == domain 10  score: 8.8 bits;  conditional E-value: 0.0012
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + LteL++  N +g+eGa+ ++
  EFC37943.1 345 NQLTELEIHTNSLGNEGAKHIS 366
                 569****************986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.4   1.0   2.3e-13   3.8e-10       2      61 .]     129     188 ..     128     188 .. 0.98
   2 !   12.4   0.2   6.3e-05       0.1      23      59 ..     198     234 ..     192     236 .. 0.87
   3 !   28.6   1.1   5.2e-10   8.5e-07       2      61 .]     249     309 ..     248     309 .. 0.96
   4 !   20.9   2.8   1.4e-07   0.00022       3      61 .]     299     357 ..     299     357 .. 0.97
   5 !   19.2   1.3   4.5e-07   0.00073       2      60 ..     322     380 ..     321     381 .. 0.97

  Alignments for each domain:
  == domain 1  score: 39.4 bits;  conditional E-value: 2.3e-13
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++s+N++++ + +  + l++L+ L++s+N+++   ++ +  L++L++Ld+s N++
  EFC37943.1 129 SLTTLYISRNNIENDGAKHISALKQLTLLNISSNNIEEEGAKYIGKLEKLTYLDISKNDI 188
                 7*********************************************************97 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 6.3e-05
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                  l++L++L +s+N+++   +  +  L++L++L   +N
  EFC37943.1 198 ELKQLTSLVISSNNIDEEGAAHLIKLTNLTELETVRN 234
                 69999************99999999999999976665 PP

  == domain 3  score: 28.6 bits;  conditional E-value: 5.2e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 +L +L++++N + + + +  + +++L++L++++N++t  ++ + f +L++L++L++++N +
  EFC37943.1 249 QLINLNINDNFIGDEGAKYISEMKQLTILNIGSNEITDrVNFENFGQLNQLTELYIEDNSI 309
                 5779*********************************99********************86 PP

  == domain 4  score: 20.9 bits;  conditional E-value: 1.4e-07
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 Lt+L++ +N+++    +  ++l+nL+ Ld+s N+ +   ++ +s++++L++L +  N L
  EFC37943.1 299 LTELYIEDNSIQTNACKYISQLQNLNLLDISGNNVDAEGAKYISQMNQLTELEIHTNSL 357
                 89****************************************************99986 PP

  == domain 5  score: 19.2 bits;  conditional E-value: 4.5e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 nL+ Ld+s N+  + + +  +++++L++L++  N+l    ++ +s ++ L++L+L +N+
  EFC37943.1 322 NLNLLDISGNNVDAEGAKYISQMNQLTELEIHTNSLGNEGAKHISTMKELEYLYLCDND 380
                 899****************************************************9997 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.2      0.28   4.6e+02      10      33 ..      91     111 ..      81     119 .. 0.65
   2 !   10.4   0.3   0.00042      0.69       1      36 [.     102     140 ..     102     147 .. 0.75
   3 !   19.0   2.3   8.7e-07    0.0014       1      34 [.     128     163 ..     128     176 .. 0.83
   4 !   19.7   1.7   5.2e-07   0.00084       1      39 [.     152     188 ..     152     195 .. 0.88
   5 !   21.5   0.6   1.4e-07   0.00022       2      39 ..     177     212 ..     176     216 .. 0.87
   6 !   14.9   0.5   1.7e-05     0.028       1      29 [.     200     230 ..     200     237 .. 0.87
   7 !   16.9   1.5     4e-06    0.0065       1      38 [.     248     286 ..     248     292 .. 0.84
   8 !   17.9   1.5   1.9e-06    0.0031       1      39 [.     272     309 ..     272     313 .. 0.79
   9 !   12.7   1.8   8.1e-05      0.13       2      34 ..     298     332 ..     297     339 .. 0.84
  10 !   10.5   1.6   0.00041      0.68       1      38 [.     321     356 ..     321     362 .. 0.83
  11 !    7.7   0.3     0.003       4.9       3      39 ..     347     381 ..     340     386 .. 0.63

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.28
                 SS---E-S-HHH-TT--EEE-.-S CS
       LRR_4  10 nNqltdiplleklpnLkeLdLsgN 33 
                  N+++ +++   l n ++L++ ++
  EFC37943.1  91 KNNVK-LNGEF-LQNIETLSV-NF 111
                 57777.55545.999999999.33 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00042
                 SS--EEE--SS---E-S-....HH.H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl....le.klpnLkeLdLsgNnli 36 
                 +n e+L+ +  +++ + +    +    ++L++L++s+Nn i
  EFC37943.1 102 QNIETLSVNF-RIKGVVFncgvFDlMSKSLTTLYISRNN-I 140
                 5788888888.999877775553356888******9993.3 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 8.7e-07
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNn 34 
                 ++L++L++s N++   ++   ++ l++L+ L++s+Nn
  EFC37943.1 128 KSLTTLYISRNNIE-NDGakhISALKQLTLLNISSNN 163
                 68************.557565445*********9993 PP

  == domain 4  score: 19.7 bits;  conditional E-value: 5.2e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L+ L++s+N++ + +   ++kl +L++Ld+s N    d+
  EFC37943.1 152 KQLTLLNISSNNIEEEGAkyIGKLEKLTYLDISKN----DI 188
                 589***********988887779************....77 PP

  == domain 5  score: 21.5 bits;  conditional E-value: 1.4e-07
                 S--EEE--SS---E-S-HH.H.-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplle.k.lpnLkeLdLsgNnlitdl 39 
                 +L++Ld+s N +++ + l+ + l++L++L +s+N    ++
  EFC37943.1 177 KLTYLDISKNDIRSNGALYiSeLKQLTSLVISSN----NI 212
                 8****************77755*********999....43 PP

  == domain 6  score: 14.9 bits;  conditional E-value: 1.7e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLd 29 
                 ++L++L +s+N++ + +   l kl+nL+eL 
  EFC37943.1 200 KQLTSLVISSNNIDEEGAahLIKLTNLTELE 230
                 58************988888889******97 PP

  == domain 7  score: 16.9 bits;  conditional E-value: 4e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++++N + d +   ++ +++L+ L++ +N  itd
  EFC37943.1 248 KQLINLNINDNFIGDEGAkyISEMKQLTILNIGSN-EITD 286
                 589************99986445*********555.7754 PP

  == domain 8  score: 17.9 bits;  conditional E-value: 1.9e-06
                 SS--EEE--SS---.E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqlt.dipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++L++++N +t  +++  +++l +L+eL++ +N    ++
  EFC37943.1 272 KQLTILNIGSNEITdRVNFenFGQLNQLTELYIEDN----SI 309
                 58************5555555558*********888....54 PP

  == domain 9  score: 12.7 bits;  conditional E-value: 8.1e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 +L++L++ +N +++     +++l nL  Ld+sgNn
  EFC37943.1 298 QLTELYIEDNSIQTNACkyISQLQNLNLLDISGNN 332
                 69***********855566557999*********4 PP

  == domain 10  score: 10.5 bits;  conditional E-value: 0.00041
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +nL  Ld+s+N++   +   ++++ +L+eL ++ N    +
  EFC37943.1 321 QNLNLLDISGNNVDAEGAkyISQMNQLTELEIHTN----S 356
                 69999*********877787667*********666....3 PP

  == domain 11  score: 7.7 bits;  conditional E-value: 0.003
                 --EEE--SS---E-S-HH......H.-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdiplle......k.lpnLkeLdLsgNnlitdl 39 
                 L++L ++ N l      +      + ++ L++L+L +N    d+
  EFC37943.1 347 LTELEIHTNSLG-----NegakhiStMKELEYLYLCDN----DV 381
                 444444433555.....034444544********9899....66 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0058       9.4       1      22 [.     129     150 ..     129     151 .. 0.86
   2 ?    5.2   0.0     0.028        45       2      22 ..     154     174 ..     153     175 .. 0.80
   3 ?    4.9   0.0     0.034        56       1      13 [.     177     189 ..     177     199 .. 0.79
   4 ?    2.2   0.0      0.26   4.3e+02       2      20 ..     202     220 ..     201     223 .. 0.78
   5 ?    3.9   0.0     0.074   1.2e+02       2      20 ..     250     268 ..     249     271 .. 0.80
   6 ?    3.1   0.0      0.14   2.2e+02       2      14 ..     274     286 ..     273     294 .. 0.84
   7 ?    4.9   0.5     0.035        57       2      21 ..     299     321 ..     298     343 .. 0.73
   8 ?   -0.1   0.0       1.5   2.4e+03       2      20 ..     347     365 ..     346     368 .. 0.81
   9 ?    2.3   0.0      0.24   3.9e+02       2      12 ..     371     381 ..     370     392 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0058
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L++s+n++++ ++ +++ 
  EFC37943.1 129 SLTTLYISRNNIENDGAKHISA 150
                 69**********9888888876 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.028
       LRR_1   2 LrhLdLsnnpllglppnsfqn 22 
                 L+ L++s+n+++  ++ ++ +
  EFC37943.1 154 LTLLNISSNNIEEEGAKYIGK 174
                 899*******98777777665 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.034
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+s n + 
  EFC37943.1 177 KLTYLDISKNDIR 189
                 79********984 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.26
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L++L +s+n+++  +++++
  EFC37943.1 202 LTSLVISSNNIDEEGAAHL 220
                 99********977666665 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.074
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L  L++++n++++ ++ ++
  EFC37943.1 250 LINLNINDNFIGDEGAKYI 268
                 778********98887766 PP

  == domain 6  score: 3.1 bits;  conditional E-value: 0.14
       LRR_1   2 LrhLdLsnnpllg 14 
                 L+ L++++n +++
  EFC37943.1 274 LTILNIGSNEITD 286
                 99*******9865 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.035
       LRR_1   2 LrhLdLsnnpl...lglppnsfq 21 
                 L++L++++n++    ++ ++ +q
  EFC37943.1 299 LTELYIEDNSIqtnACKYISQLQ 321
                 88999999997655333333333 PP

  == domain 8  score: -0.1 bits;  conditional E-value: 1.5
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L++L +  n+l++ ++ ++
  EFC37943.1 347 LTELEIHTNSLGNEGAKHI 365
                 999***9999988777776 PP

  == domain 9  score: 2.3 bits;  conditional E-value: 0.24
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L+L++n  
  EFC37943.1 371 LEYLYLCDNDV 381
                 9*******986 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.2     0.003       4.8      62     147 ..     100     183 ..      88     185 .. 0.60
   2 !   12.4   2.8     5e-05     0.082      34     125 ..     140     236 ..     131     255 .. 0.81
   3 !   11.0   0.8   0.00013      0.22      63     147 ..     247     328 ..     238     341 .. 0.65
   4 !    5.1   0.2    0.0091        15      63     132 ..     320     390 ..     317     399 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.003
       LRR_9  62 llkrlktlllnnnrivri..aegleevl.PnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldf 147
                 +l+ ++tl++n  ri  +  + g+ + +  +l++l ++ n++++ +  + +  lk+l+ll + +n +   +e     i kl++l+ ld 
  EFC37943.1 100 FLQNIETLSVN-FRIKGVvfNCGVFDLMsKSLTTLYISRNNIENDGA-KHISALKQLTLLNISSNNI---EEEGAKYIGKLEKLTYLDI 183
                 67778888775.46655412444444441568888888888887666.5555566665555555554...4444455677777777775 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 5e-05
       LRR_9  34 ienlGa....tldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 ien Ga    +l q+  +++s n+i +     +  l++l  l +++n i+  +      l +l++lv+++n+++e +    l++l +l+ l  ++n  
  EFC37943.1 140 IENDGAkhisALKQLTLLNISSNNIEEegAKYIGKLEKLTYLDISKNDIRSNGALYISELKQLTSLVISSNNIDEEGA-AHLIKLTNLTELETVRNEF 236
                 6666663333589999999*****987222345667888889999****9999999999**************99888.7899999999999888865 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00013
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldf 147
                 +k+l  l +n+n i   + +    + +l+ l + +ne+++ ++++ + +l++l+ l + +n++ ++    +y i +l++l lld 
  EFC37943.1 247 MKQLINLNINDNFIGDEGAKYISEMKQLTILNIGSNEITDRVNFENFGQLNQLTELYIEDNSIQTNA--CKY-ISQLQNLNLLDI 328
                 5666666777777766666666666666666777777777777777777777777777777764432..223.456666666664 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.0091
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn..kkeyr 132
                 l+ l+ l ++ n +   + +    + +l+el +  n+l + +  + + ++k+le+l l +n v+   k++ r
  EFC37943.1 320 LQNLNLLDISGNNVDAEGAKYISQMNQLTELEIHTNSLGNEGA-KHISTMKELEYLYLCDNDVSVevKQHIR 390
                 6778888888888888888888889999999999999999887.899**************98751145554 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   2.9e-06    0.0047       4      36 ..      46      81 ..      45      85 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 2.9e-06
  F-box-like  4 LPdEiLlqIFsyLpps...dLlrlalVCrrWrrval 36
                LPd+++ ++++y + +      ++alV+++W +v+l
  EFC37943.1 46 LPDDVIYEVLHYYSGNfkfIVMNCALVSKQWLNVIL 81
                9**********976444366999**********996 PP

>> Spore_YhaL  Sporulation protein YhaL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0    0.0075        12      31      47 ..     161     177 ..     158     179 .. 0.88
   2 ?   -1.7   0.0       1.4   2.3e+03      32      45 ..     210     223 ..     207     226 .. 0.79
   3 ?    2.3   0.0     0.084   1.4e+02      29      46 ..     255     272 ..     247     274 .. 0.88
   4 ?   -1.0   0.0       0.9   1.5e+03      33      47 ..     332     346 ..     328     349 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0075
  Spore_YhaL  31 qefIEkEGevylerlee 47 
                  ++IE+EG  y+ +le+
  EFC37943.1 161 SNNIEEEGAKYIGKLEK 177
                 579**********9997 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.4
  Spore_YhaL  32 efIEkEGevylerl 45 
                 ++I++EG   l +l
  EFC37943.1 210 NNIDEEGAAHLIKL 223
                 68*****9887665 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.084
  Spore_YhaL  29 ldqefIEkEGevylerle 46 
                 ++++fI  EG  y+  ++
  EFC37943.1 255 INDNFIGDEGAKYISEMK 272
                 6789**********9997 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.9
  Spore_YhaL  33 fIEkEGevylerlee 47 
                 +++ EG  y+  +++
  EFC37943.1 332 NVDAEGAKYISQMNQ 346
                 6789******99976 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1    0.0001      0.17       6      37 ..      46      80 ..      45      90 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.0001
                S-HHHHHHHHHTS-HHH...HHHHCTT-HHHHHHH CS
       F-box  6 LPsevlrhILerLplsd...llalrrVSkgwrili 37
                LP++v+ ++L + +      + ++++VSk w ++i
  EFC37943.1 46 LPDDVIYEVLHYYSGNFkfiVMNCALVSKQWLNVI 80
                89999999999977777999************998 PP

>> YmcE_antitoxin  Putative antitoxin of bacterial toxin-antitoxin system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.035        58       4      35 ..     134     164 ..     131     170 .. 0.88
   2 ?    5.8   0.0    0.0091        15       5      35 ..     183     212 ..     180     219 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.035
  YmcE_antitoxin   4 wisqnnirlprgaffisalfffnavcivsdnl 35 
                     +is+nni    ga  isal  +  + i s+n+
      EFC37943.1 134 YISRNNIE-NDGAKHISALKQLTLLNISSNNI 164
                     89*****8.57********9999999999885 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0091
  YmcE_antitoxin   5 isqnnirlprgaffisalfffnavcivsdnl 35 
                     is+n+ir   ga++is l  + +++i s+n+
      EFC37943.1 183 ISKNDIR-SNGALYISELKQLTSLVISSNNI 212
                     89****9.58***************999996 PP

>> RNA_pol_I_TF  RNA polymerase I specific initiation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.2   0.00078       1.3      16      57 ..     123     164 ..     118     184 .. 0.91
   2 ?   -0.3   0.0      0.38   6.2e+02      20      56 ..     175     211 ..     163     214 .. 0.69
   3 ?    3.9   0.1      0.02        33      12      53 ..     215     256 ..     203     260 .. 0.86
   4 ?   -0.0   0.1      0.33   5.3e+02      16      54 ..     340     378 ..     308     389 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00078
  RNA_pol_I_TF  16 flikskglevlpdskseirsyktkhienltqllhlnilrrnw 57 
                   f+ +sk l +l  s ++i++   khi++l+ql  lni+++n 
    EFC37943.1 123 FDLMSKSLTTLYISRNNIENDGAKHISALKQLTLLNISSNNI 164
                   788889999999999***********************9996 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.38
  RNA_pol_I_TF  20 skglevlpdskseirsyktkhienltqllhlnilrrn 56 
                    + l  l+ sk++irs+    i++l+ql  l i+++n
    EFC37943.1 175 LEKLTYLDISKNDIRSNGALYISELKQLTSLVISSNN 211
                   4555666677888888888888888888877777776 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.02
  RNA_pol_I_TF  12 akanflikskglevlpdskseirsyktkhienltqllhlnil 53 
                   + a +lik + l  l+++ +e   +  khi++++ql+ lni 
    EFC37943.1 215 EGAAHLIKLTNLTELETVRNEFGAEGAKHISEMKQLINLNIN 256
                   5567889999999999999********************995 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 0.33
  RNA_pol_I_TF  16 flikskglevlpdskseirsyktkhienltqllhlnilr 54 
                   + ++ + l  l+  ++++ ++  khi+++++l +l +  
    EFC37943.1 340 YISQMNQLTELEIHTNSLGNEGAKHISTMKELEYLYLCD 378
                   444555555566667788888889999999887776655 PP

>> DUF1462  Protein of unknown function (DUF1462)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       3.1   5.1e+03      51      69 ..      29      47 ..      15      56 .. 0.51
   2 ?    3.8   0.0     0.044        72      32      90 ..     170     225 ..     165     228 .. 0.78
   3 ?    5.0   0.2     0.018        29      31      93 .]     338     397 ..     314     397 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 3.1
     DUF1462 51 eeekkefaekiledelfyP 69
                ++e++   +k++e++++ P
  EFC37943.1 29 NSESELKKKKLKEQNYILP 47
                3333333344444444444 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.044
     DUF1462  32 kypeqkleleyvDieeekeeeekkefaekiledelfyPlvviedevvaeGnpklkkiyk 90 
                 ky  +  +l+y+Di+++     +++ a  i e + +  lv+ ++++ +eG  +l k+++
  EFC37943.1 170 KYIGKLEKLTYLDISKND---IRSNGALYISELKQLTSLVISSNNIDEEGAAHLIKLTN 225
                 788888899*****7765...55556666777777889999999999999999887765 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.018
     DUF1462  31 rkypeqkleleyvDieeekeeeekkefaekiledelfyPlvviedevvaeGnpklkkiykele 93 
                  ky +q+ +l+ ++i++++  +e ++ +++++e e++y   + +++v  e + ++++iy+ ++
  EFC37943.1 338 AKYISQMNQLTELEIHTNSLGNEGAKHISTMKELEYLY---LCDNDVSVEVKQHIREIYQDID 397
                 5999999999999**99999999999999****9*999...78999999*********99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       919  (0.0512577); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2459.65
//
Query:       EFC37944.1  [L=560]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      8e-50  167.1   7.9    1.3e-15   57.2   0.0    4.2  3  Thioredoxin    Thioredoxin
    5.1e-07   30.1   3.7       0.61   10.6   0.0    5.3  4  Thioredoxin_2  Thioredoxin-like domain
      2e-06   27.4   3.7       0.14   11.4   0.1    3.3  3  OST3_OST6      OST3 / OST6 family, transporter family
     0.0047   16.0   2.0     0.0086   15.1   2.0    1.4  1  eIF-3_zeta     Eukaryotic translation initiation factor 3 sub
     0.0051   16.7   0.5      0.016   15.1   0.1    1.9  2  NTNH_C         Nontoxic nonhaemagglutinin C-terminal
     0.0059   16.6   0.0        3.2    7.8   0.0    3.4  4  HyaE           Hydrogenase-1 expression protein HyaE
  ------ inclusion threshold ------
      0.022   14.6   0.0         92    2.8   0.0    2.9  2  Coilin_N       Coilin N-terminus
      0.046   14.0   0.4       0.46   10.7   0.1    2.6  2  Glutaredoxin   Glutaredoxin


Domain annotation for each model (and alignments):
>> Thioredoxin  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.2   0.0   5.8e-19   1.3e-15       4      91 ..     125     210 ..     122     220 .. 0.94
   2 !   53.8   0.8     7e-18   1.6e-14       4      93 ..     238     314 ..     235     322 .. 0.90
   3 !   55.7   0.2   1.8e-18     4e-15       4     102 ..     348     443 ..     345     444 .. 0.92

  Alignments for each domain:
  == domain 1  score: 57.2 bits;  conditional E-value: 5.8e-19
                  ESSHHHHHHHHTTTSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTTTSEEEEEETTTSHHHHHHTT-SSSSEEEEEETTEEEEEEESS CS
  Thioredoxin   4 vltkenFeeevakekklvlveFyApwCghCkalaPeleklaeelkdkvklakvdvdenedlakkyevegiPtlklfkngkevkkyega 91 
                  + ++e+F++ +ak +  v+v F +p+Cg C+     +e la+e   kv +akvd+++ + +a++y+ +++Pt++++ +g+ v+k++g 
   EFC37944.1 125 IQSEEEFRSLIAK-NPSVVVYFSSPYCGVCRDYDANYEGLASEKP-KVNFAKVDINNFSGIADEYGAKCLPTFLFISQGEVVQKLDGL 210
                  567899*******.*****************************99.************************************999986 PP

  == domain 2  score: 53.8 bits;  conditional E-value: 7e-18
                  ESSHHHHHHHHTTTSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTTTSEEEEEETTTSHHHHHHTT-SSSSEEEEEETTEEEEEEESS-H CS
  Thioredoxin   4 vltkenFeeevakekklvlveFyApwCghCkalaPeleklaeelkdkvklakvdvdenedlakkyevegiPtlklfkngkevkkyegare 93 
                  ++++++F++++++ k++v+v+FyA+wCg           la +++ +v+++kv+vde++++ +k++v+++Pt+++f ngk  +++ g+++
   EFC37944.1 238 IVKEKDFDDTIKS-KTKVVVDFYADWCG-----------LAAKHT-DVTFMKVNVDEHRKIMSKCDVHAMPTFVFFYNGKMKETVIGGSS 314
                  678999******9.**************...........566777.8*********************************9999999876 PP

  == domain 3  score: 55.7 bits;  conditional E-value: 1.8e-18
                  ESSHHHHHHHHTTTSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTTTSEEEEEETTTSHHHHHHTT-SSSSEEEEEETTEEEEEEESS-HHHHHHHHH CS
  Thioredoxin   4 vltkenFeeevakekklvlveFyApwCghCkalaPeleklaeelkdkvklakvdvdenedlakkyevegiPtlklfkngkevkkyegarekeklaafl 101
                  v ++e++++ +++ ++lv+ ++y + Cg C a a  + kla   + kvk++kvd+ +  ++ +k  ++++Pt+klf++gke+k++eg ++ ++l++ +
   EFC37944.1 348 VKSEEEYNHVLKD-NSLVVADYYGDNCGACVACATPYSKLAFSNQ-KVKFIKVDTSKLYSITSKERISCLPTFKLFHHGKESKRLEGFSQ-KELETAI 442
                  5678899999999.***************************9988.*****************************************998.7777776 PP

                  H CS
  Thioredoxin 102 k 102
                  k
   EFC37944.1 443 K 443
                  5 PP

>> Thioredoxin_2  Thioredoxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.1   0.00032      0.71       5      99 ..     138     210 ..     134     214 .. 0.75
   2 ?    4.5   0.1     0.021        46       3      26 ..     249     272 ..     247     279 .. 0.80
   3 !   10.6   0.0   0.00027      0.61      66      99 ..     279     312 ..     266     322 .. 0.72
   4 ?    1.0   0.1      0.26   5.8e+02       8      32 ..     364     392 ..     357     442 .. 0.50

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00032
  Thioredoxin_2   5 gkpvlvvftdpdCpyCkklkkelkelddvtvrvllfplkpsfepkavaiwcakekkkafkdieenvelarkygvrgtPtivfldgkeivarlpGy 99 
                    +  v+v+f++p C+ C+   ++ + l            +++ +  +++++ ++               a++yg + +Pt++f+ + e+v +l G+
     EFC37944.1 138 NPSVVVYFSSPYCGVCRDYDANYEGL-----------ASEKPKVNFAKVDINNFSG-----------IADEYGAKCLPTFLFISQGEVVQKLDGL 210
                    5679999***********99988888...........3444445555555555554...........7899999999998888888788888886 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.021
  Thioredoxin_2   3 gngkpvlvvftdpdCpyCkklkke 26 
                    +++ +v+v+f++++C+  +k  ++
     EFC37944.1 249 KSKTKVVVDFYADWCGLAAKHTDV 272
                    67899***********99996664 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00027
  Thioredoxin_2  66 ieenvelarkygvrgtPtiv.fldgkeivarlpGy 99 
                    ++e+++ + k +v+++Pt+v f++gk + +++ G 
     EFC37944.1 279 VDEHRKIMSKCDVHAMPTFVfFYNGK-MKETVIGG 312
                    799***************66599**9.33344443 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.26
  Thioredoxin_2   8 vlvvftdpdCpyCkklkkelkel....dd 32 
                    v+++++ ++C+ C +  +  ++l    ++
     EFC37944.1 364 VVADYYGDNCGACVACATPYSKLafsnQK 392
                    66666677777766665555555222222 PP

>> OST3_OST6  OST3 / OST6 family, transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.1   7.3e-05      0.16      19     141 ..     129     256 ..     113     262 .. 0.73
   2 !   11.4   0.1   6.5e-05      0.14      66     108 ..     261     306 ..     241     349 .. 0.82
   3 !    5.0   0.2    0.0059        13      44     120 ..     371     443 ..     336     481 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 7.3e-05
   OST3_OST6  19 enykellkgprdysvvvllTatspqfkCelCrefepefelvakswrkdekskskklfFakvdfdegkdvFqklglnsaPhlllfpp............. 104
                 e++++l++  ++ svvv++ +      C +Cr+ + ++e +a+         + k+ Fakvd+++ + +  ++g + +P +l++++             
  EFC37944.1 129 EEFRSLIA--KNPSVVVYFSSP----YCGVCRDYDANYEGLASE--------KPKVNFAKVDINNFSGIADEYGAKCLPTFLFISQgevvqkldglces 213
                 66777774..788899999887....699999999999999864........34788***************************995555555555444 PP

   OST3_OST6 105 ..kkgpkesk......kkdtydfsrggf....daealakfisertgvki 141
                   +      +      k+ + +f ++g     + +++ + i+++t+v +
  EFC37944.1 214 ivS------RnadmlaKQLEPPFYENGIlhivKEKDFDDTIKSKTKVVV 256
                 331......0233444666777776665556677777777777777665 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 6.5e-05
   OST3_OST6  66 d...ekskskklfFakvdfdegkdvFqklglnsaPhlllfppkkgp 108
                 d    ++k++++ F+kv++de +++++k  +   P +++f   k +
  EFC37944.1 261 DwcgLAAKHTDVTFMKVNVDEHRKIMSKCDVHAMPTFVFFYNGKMK 306
                 3455457899******************************884433 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0059
   OST3_OST6  44 fkCelCrefepefelvakswrkdekskskklfFakvdfdegkdvFqklglnsaPhlllfppkkgpk..esk...kkdtydfs 120
                  +C  C   ++ ++++a s +        k+ F+kvd ++  ++ +k +++ +P + lf+  k+ k  e     k+ +  ++
  EFC37944.1 371 DNCGACVACATPYSKLAFSNQ--------KVKFIKVDTSKLYSITSKERISCLPTFKLFHHGKESKrlE-GfsqKELETAIK 443
                 567777777777777775544........566***************************9976666442.122344444443 PP

>> eIF-3_zeta  Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   2.0   3.8e-06    0.0086     106     206 ..      54     168 ..      17     186 .. 0.61

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 3.8e-06
                 ............XXXXXXXXXX..............................XXXXXXXXXX-----TT-EEEEEEEHHHHHT--TT----EEEEEEEE CS
  eIF-3_zeta 106 e...........rqqqqalnkkqgeeekeerskkkkkkk.kgrrk.gwkdk.kdkeqrnreasvevkpeWkvleeidfsrLsklslevkepedlesyGk 190
                 +           ++qq   ++ q++++k+ +s++ +++  ++r    +++  ++    + ++s+e+++  k+ +e +f +L   +++v        +G 
  EFC37944.1  54 KnmppnhqnkppKKQQDGKQQGQQQGNKHPESAQDQNNDnNNRDGeSNQRGrRRGFPFESNKSIEMTNFTKIQSEEEFRSLIAKNPSVVVYFSSPYCGV 152
                 12223333333333333333333333333333333322213333322222212333348899***************************99******** PP

                 E-BB-GGGGG-BTTB- CS
  eIF-3_zeta 191 leyYdksydrittkne 206
                  + Yd +y+ +  +++
  EFC37944.1 153 CRDYDANYEGLASEKP 168
                 ********98875544 PP

>> NTNH_C  Nontoxic nonhaemagglutinin C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.84   1.9e+03     107     134 ..     278     305 ..     235     312 .. 0.77
   2 !   15.1   0.1   7.3e-06     0.016       4      86 ..     330     416 ..     328     456 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.84
      NTNH_C 107 skdtakkiiisndifksncltlaynnky 134
                 + d+ +ki+ + d+     + + yn+k 
  EFC37944.1 278 NVDEHRKIMSKCDVHAMPTFVFFYNGKM 305
                 5677889999999999999999999985 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 7.3e-06
      NTNH_C   4 evlnnsyirdiseerleynkiyelynyvfsekslyevk...ennniyls.ikdtndlnlqaakfkllsidtnkqyvqkldevvvsll 86 
                 e+l++  +  +s+e + y k  e yn+v+ ++sl+      +n    ++      +l +   k k++++dt k y     e + +l 
  EFC37944.1 330 EYLKKDMLAGSSDEFVTYVKSEEEYNHVLKDNSLVVADyygDNCGACVAcATPYSKLAFSNQKVKFIKVDTSKLYSITSKERISCLP 416
                 6888889999***********************986542113333333303456799******************999999988873 PP

>> HyaE  Hydrogenase-1 expression protein HyaE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.1   2.4e+03      12      35 ..     123     147 ..     114     153 .. 0.68
   2 !    7.8   0.0    0.0014       3.2      71     102 ..     179     210 ..     166     212 .. 0.85
   3 ?    4.2   0.0     0.018        40      69      96 ..     279     306 ..     265     314 .. 0.80
   4 ?   -3.3   0.0         4   8.9e+03      61      94 ..     392     425 ..     387     433 .. 0.61

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.1
                 EEE-.CCCHHHHHHHHSEEEEEESS CS
        HyaE  12 aevd.adtlddflkaagdavlllag 35 
                 ++++ +++ ++++++++  v+++++
  EFC37944.1 123 TKIQsEEEFRSLIAKNPSVVVYFSS 147
                 5554466777788888887777765 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0014
                 HHHHHHHCCT-TSSSEEEEEETTEEEEEEESS CS
        HyaE  71 qeealaerfgvlktPsllflrdgeylgvlaki 102
                 + + +a+++g +  P++lf+ +ge++  l+++
  EFC37944.1 179 NFSGIADEYGAKCLPTFLFISQGEVVQKLDGL 210
                 556799*******************9999886 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.018
                 HHHHHHHHHCCT-TSSSEEEEEETTEEE CS
        HyaE  69 reqeealaerfgvlktPsllflrdgeyl 96 
                  ++  ++ ++  v  +P+++f+ +g++ 
  EFC37944.1 279 VDEHRKIMSKCDVHAMPTFVFFYNGKMK 306
                 4566789999*************99976 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 4
                 -EEEEEETHHHHHHHHHCCT-TSSSEEEEEETTE CS
        HyaE  61 lraavvadreqeealaerfgvlktPsllflrdge 94 
                 +   +  d+ +   + ++ +++  P++ ++ +g+
  EFC37944.1 392 KVKFIKVDTSKLYSITSKERISCLPTFKLFHHGK 425
                 4444444566666677777777777777776665 PP

>> Coilin_N  Coilin N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   8.1       0.3   6.7e+02      97     132 ..      57      93 ..      41     100 .. 0.37
   2 ?    2.8   0.0     0.041        92      65      76 ..     356     479 ..     340     551 .. 0.55

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.3
    Coilin_N  97 sasksa.sttkqkkkkKrekkqeeqdeqkasqaakdk 132
                   + ++  ++kq++ k + ++q ++  ++a+ +++d+
  EFC37944.1  57 PPNHQNkPPKKQQDGKQQGQQQGNKHPESAQDQNNDN 93 
                 2222220333333333333333333334444444443 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.041
    Coilin_N  65 rvlrdndcirV........................................................................................ 75 
                 +vl+dn+ + +                                                                                        
  EFC37944.1 356 HVLKDNSLVVAdyygdncgacvacatpysklafsnqkvkfikvdtsklysitskerisclptfklfhhgkeskrlegfsqkeletaiknliakegsscs 454
                 677777776667777777777777777777777777666666666666666666666666666666666666666666554444444444444444443 PP

    Coilin_N  76 ........................k 76 
                                         +
  EFC37944.1 455 sttattkptttvssqptvsktvtkS 479
                 3333333333333333322222220 PP

>> Glutaredoxin  Glutaredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   0.00021      0.46       1      43 [.     142     189 ..     142     198 .. 0.75
   2 ?   -0.8   0.0      0.84   1.9e+03      20      38 ..     268     286 ..     265     299 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00021
                   EEEEESTSSHHHHHHHHHH.....HHTTGGEEEEEGCCSHHHHHHHHH CS
  Glutaredoxin   1 vvlftkptCpyCkkakrlL.....kelgvkfeeidvdkdeeireelke 43 
                   vv+f++p+C+ C+   +       ++ +v+f+ +d+++ + i +e  +
    EFC37944.1 142 VVYFSSPYCGVCRDYDANYeglasEKPKVNFAKVDINNFSGIADEYGA 189
                   8***********877665522235555599999999999999998755 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.84
                   HHTTGGEEEEEGCCSHHHH CS
  Glutaredoxin  20 kelgvkfeeidvdkdeeir 38 
                   k   v f  ++vd++ +i 
    EFC37944.1 268 KHTDVTFMKVNVDEHRKIM 286
                   5567889999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (560 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1505  (0.0839422); expected 358.6 (0.02)
Passed bias filter:                      531  (0.0296168); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 3183.61
//
Query:       EFC37945.1  [L=186]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   12.2   1.1        1.4    8.9   0.2    2.1  2  CCDC32    Coiled-coil domain containing 32


Domain annotation for each model (and alignments):
>> CCDC32  Coiled-coil domain containing 32
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.2     8e-05       1.4      62     106 ..      98     142 ..      94     151 .. 0.90
   2 ?    2.2   0.1    0.0092   1.7e+02      67      98 ..     151     182 ..     142     186 .] 0.86

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 8e-05
      CCDC32  62 vYlasLErkLkkikkqskevtskdlLesLsqkkkecwdrlLadev 106
                  Yl+ + + L+ +k+ +k+ t  dlL+ L q k   +d l  +++
  EFC37945.1  98 HYLKIMNNLLEILKEPTKHFTHVDLLKGLLQLKSSTMDALRFENQ 142
                 6*************************************9876654 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.0092
      CCDC32  67 LErkLkkikkqskevtskdlLesLsqkkkecw 98 
                  E+ L+ i + s+   s  + esL++  + c 
  EFC37945.1 151 YEQTLREICNISRTTDSSHMAESLDNIYQTCK 182
                 6999*********99*********99998885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       748  (0.0417201); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1152.47
//
Query:       EFC37946.1  [L=953]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.1e-34  116.4   7.4    1.2e-10   40.9   0.1    6.7  7  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.2      0.35   6.2e+03      11      21 ..     529     539 ..     511     549 .. 0.61
   2 !   36.0   0.0   2.3e-13   4.2e-09       3      49 .]     705     751 ..     703     751 .. 0.97
   3 !   40.9   0.1   6.7e-15   1.2e-10       1      49 []     728     776 ..     728     776 .. 0.96
   4 !   28.4   0.1   5.6e-11     1e-06       4      44 ..     756     796 ..     753     797 .. 0.92
   5 !   23.9   0.0   1.4e-09   2.5e-05       5      49 .]     782     826 ..     781     826 .. 0.97
   6 !   22.4   0.0   4.2e-09   7.5e-05       8      48 ..     835     875 ..     829     876 .. 0.89
   7 !    4.9   0.3    0.0012        22      25      44 ..     875     899 ..     871     906 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.35
     DUF4116  11 kngsalkylse 21 
                 +n+++l+ l e
  EFC37946.1 529 RNCCNLELLKE 539
                 45555555544 PP

  == domain 2  score: 36.0 bits;  conditional E-value: 2.3e-13
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 E ++e+++ ng+al++l+++++ D  +v  Avk+ g +l+yase Lr
  EFC37946.1 705 ETMKELLEFNGYALEFLPNSFQDDESLVSIAVKSRGLSLKYASERLR 751
                 889*****************************************998 PP

  == domain 3  score: 40.9 bits;  conditional E-value: 6.7e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+ +v  avk+ g++lky+se+L+n+  iv  Av qn ++++yas eL+
  EFC37946.1 728 DESLVSIAVKSRGLSLKYASERLRNNPTIVDLAVSQNYYSFEYASRELK 776
                 7788999***************************************997 PP

  == domain 4  score: 28.4 bits;  conditional E-value: 5.6e-11
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 iv  av++n ++++y+s eLknDk  +l+ v++ng  l+ +
  EFC37946.1 756 IVDLAVSQNYYSFEYASRELKNDKMKILEYVERNGLLLEIV 796
                 7778*******************************999866 PP

  == domain 5  score: 23.9 bits;  conditional E-value: 1.4e-09
     DUF4116   5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +le+v++ng+ l+ ++  +k D +iv  A+ qn+ ++ +ase+++
  EFC37946.1 782 ILEYVERNGLLLEIVPGIFKEDLQIVQMAIAQNPLSIQFASEKFK 826
                 79***************************************9986 PP

  == domain 6  score: 22.4 bits;  conditional E-value: 4.2e-09
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 +++k g+ lk++s++L++D +i+l A k  g a+ y  ++L
  EFC37946.1 835 LIEKKGELLKFASNSLQSDSNIILTATKTFGLAILYSTKKL 875
                 799******************************99987766 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.0012
     DUF4116  25 nDkeivlkAvkqngt.....alsya 44 
                  D e++l +vk+n+      +l+y+
  EFC37946.1 875 LDTELILDCVKINKLyenkqILNYV 899
                 599********99854666678887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (953 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       829  (0.0462379); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.50
# Mc/sec: 5782.76
//
Query:       EFC37947.1  [L=751]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-05   23.8   2.2    8.1e-05   22.5   2.2    1.7  1  dCache_1       Cache domain
     0.0012   18.5   0.2     0.0033   17.1   0.1    1.8  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
       0.74   10.1   3.6         54    4.2   0.0    4.3  5  RL11D          Glycoprotein encoding membrane proteins RL5A a


Domain annotation for each model (and alignments):
>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   2.2   1.3e-08   8.1e-05     100     201 ..      83     244 ..      11     284 .. 0.70

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 1.3e-08
    dCache_1 100 g...............................tddpadrdwykealaggg...gkpvisdpy.vdqtggkpvitiavpiyd.......dsgkfiGvlaa 156
                                                 t+ +++++++++ l+  +   + ++i++py v  + +   i+++++iy+       ++ + iG++  
  EFC37947.1  83 LtyleklnegiifwnvnetdgsttsvfrndssTYHVTEQPYWNQSLQLFEelqTNVIIGEPYlVV-N-SGMAIYCSTKIYNsshylhtRQKQLIGIAKS 179
                 2344444444444444444445555788888889*******9999987668999999*****754.4.45**********6333333455699****** PP

    dCache_1 157 dldldnlqdllsniklgetgyvfivdsdGniiahpdkdl....................lgknlr 201
                 +l l+++q++l+++ l ++gyv + + ++++i  + ++                     l+k++r
  EFC37947.1 180 NLMLNSIQEFLQELTLIGNGYVILAELNDLVIGASINSSssegrsrvsifdltdkdagqLMKDVR 244
                 **************99999*************976643334456666666666666555444444 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.1   6.4e+03      61      85 ..     283     307 ..     282     314 .. 0.76
   2 !   17.1   0.1   5.5e-07    0.0033      72     171 ..     509     611 ..     446     623 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.1
  Guanylate_cyc  61 ymvvsglpeekaahaaklaelaLdm 85 
                    ymvv+++  ek++++++ ++++ ++
     EFC37947.1 283 YMVVFKSDVEKTTNINSGISVGVAI 307
                    8999998888888887777766655 PP

  == domain 2  score: 17.1 bits;  conditional E-value: 5.5e-07
  Guanylate_cyc  72 aahaaklaelaLdmlealeevaveskeglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagkiqv...seetyellkeeqfelt 163
                    ++  ++++e +L++ + l+++  +s+++l   +Gi t   ++g +G ++ + y + G  v  A ++ + g++ ++++   s ++  +   +q+ l+
     EFC37947.1 509 KKCESSAIEASLKICKILDNIHGKSERKLCYSIGIFTDMAFVGNVGsNSLRSYSIVGPIVQNARKLATFGQTLDCKIlvdSGSVSPIII-NQYVLR 603
                    34445678999***********************************888899*******************999988778888888887.888888 PP

  Guanylate_cyc 164 ergevevk 171
                     +++ e++
     EFC37947.1 604 PVDRLEME 611
                    88888886 PP

>> RL11D  Glycoprotein encoding membrane proteins RL5A and RL6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.74   4.4e+03      14      47 ..     168     201 ..     159     243 .. 0.74
   2 ?    2.5   0.1     0.029   1.7e+02      55      84 ..     343     372 ..     336     383 .. 0.89
   3 ?   -0.8   0.0      0.32   1.9e+03      21      59 ..     390     428 ..     380     448 .. 0.72
   4 ?    4.2   0.0     0.009        54       4      55 ..     434     485 ..     431     510 .. 0.87
   5 ?   -0.1   0.0       0.2   1.2e+03      45      69 ..     503     526 ..     490     534 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.74
       RL11D  14 vddkdrlsikwktvfgddGdeslydvtgiGtavv 47 
                 + +k+ + i    ++ +  +e+l ++t iG+  v
  EFC37947.1 168 TRQKQLIGIAKSNLMLNSIQEFLQELTLIGNGYV 201
                 5566666677777778888888888888888654 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.029
       RL11D  55 vsscshtsldlcnlksqddslfdlsrrlge 84 
                 + sc+ +s ++ ++ s  + lfd+  +l+e
  EFC37947.1 343 LKSCNFNSSKFKEVDSIYEHLFDMVTWLNE 372
                 679**************************7 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.32
       RL11D  21 sikwktvfgddGdeslydvtgiGtavvngnaticvsscs 59 
                  ++wk  + ++ ++s+   ++iGt+ +   +t+  s+ s
  EFC37947.1 390 QVEWKPSLFEKDQQSIKVSSEIGTSKMIKTSTLRNSTTS 428
                 578998888888888888888998877666665555433 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.009
       RL11D   4 kastGsnltivddkdrlsikwktvfgddGdeslydvtgiGtavvngnaticv 55 
                 k +tGs + +  +  r+s+    +fg + d s  d+++i + + ng +t+c 
  EFC37947.1 434 KITTGSLFKLGLNYSRISVVNVKLFGFNEDTSAHDLSNIFSKIANGLSTLCK 485
                 678999999999999999999999***************************5 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 0.2
       RL11D  45 avvngnaticvsscshtsldlcnlk 69 
                 + v+gn   c ss   +sl++c + 
  EFC37947.1 503 TFVDGNK-KCESSAIEASLKICKIL 526
                 6677775.69************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (751 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       797  (0.0444531); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.76u 0.30s 00:00:01.06 Elapsed: 00:00:00.50
# Mc/sec: 4500.23
//
Query:       EFC37948.1  [L=633]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.5e-43  145.8   0.0    2.3e-42  144.4   0.0    1.8  1  Ras       Ras family
    2.8e-22   79.0   7.6    2.4e-17   63.1   0.2    4.2  3  BTB       BTB/POZ domain
    2.8e-19   69.5   0.0    9.7e-19   67.8   0.0    2.0  1  Roc       Ras of Complex, Roc, domain of DAPkinase
      8e-05   22.2   0.0    0.00016   21.2   0.0    1.5  1  Arf       ADP-ribosylation factor family
     0.0037   17.3   0.0       0.67   10.1   0.0    2.5  2  BACK      BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  144.4   0.0   6.3e-46   2.3e-42       1     160 [.       6     169 ..       6     171 .. 0.95

  Alignments for each domain:
  == domain 1  score: 144.4 bits;  conditional E-value: 6.3e-46
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 Klv+vGd+avGK++ll+  ++++F+e+y +T+ +d+y++++++ ++++++ +wDTAGqe++++lr+l+y +++++++++++ +r+sf nvk kw+ e+ 
  EFC37948.1   6 KLVVVGDGAVGKSCLLIASTTNSFPEDYVPTV-FDNYSANVTYGNRNYNVGLWDTAGQEDYDRLRPLSYPGTDVFFVCFSMVNRASFANVKsKWIPELI 103
                 99******************************.**********************************************************9******* PP

                 HHSTTTSEEEEEEETTTGGG....G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee....kravsteegeelakelg.lkfletSAktnenveeafeellrei 160
                 ++++ ++pi+LvG K+Dl +    +  +++e  e++ ++      + tS +t +n++++f+ +++++
  EFC37948.1 104 HHCP-DIPIILVGCKSDLVSdadrDSIITQEMIEQMVQNSPaSGSIVTSSRTMYNIDKLFNLAISQA 169
                 ****.5************9888877889999999999988868899**************9988775 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   1.1   2.6e-05     0.093       1      45 [.     218     276 ..     218     373 .. 0.75
   2 !   63.1   0.2   6.8e-21   2.4e-17       2     110 ..     397     512 ..     396     513 .. 0.91
   3 ?    2.4   0.0      0.05   1.8e+02      82     110 ..     526     554 ..     519     555 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.6e-05
                 HHHHHHHTTTS-EEEEETT.....TEEEEE-HHHHHHH.-HHHHHHHTST........T CS
         BTB   1 lnelresgelcDvtlvvgd.....gkefkahkavLaar.SpyFkalftsk........e 45 
                 +++l++s+  cD  +v+ +     + e+kah +vLa+  S++ ++lf +         +
  EFC37948.1 218 FKNLLDSDFCCDTKFVIYNstkdiDVEIKAHSLVLACVpSKVIRKLFDDVlvcrdagmN 276
                 68899999************9*9************9755********987555444440 PP

  == domain 2  score: 63.1 bits;  conditional E-value: 6.8e-21
                 HHHHHHTTTS-EEEEETT...TEEEEE-HHHHHHH-HHHHHHHTST..TTTTCCCE......EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHH CS
         BTB   2 nelresgelcDvtlvvgd...gkefkahkavLaarSpyFkalftsk..eieessvs......eielddvepeafealLefiYtgeleitseenleelLa 89 
                 ++++++++ +Dv +v+ +    k f+ hk++L+a  ++F+++f+++  e   +s+       ei  ++   ++f+al+e++Y+++ +i+ e n++ lL+
  EFC37948.1 397 KKYFDKKTHSDVEIVFSTtdsSKNFQGHKLFLSANCDVFRTMFEGNfvE---HSSRqvdlsgEIGENENRISEFHALFEYLYSAHSTIN-ERNAVGLLS 491
                 5789999*********999999************************553...443334588999999*********************7.********* PP

                 HHHHHT-HHHHHHHHHHHHHH CS
         BTB  90 aadllqiprlkkaceeflkqs 110
                 +a+ + +  l+ +ce f++++
  EFC37948.1 492 LANEYGMSGLTSMCEIFISKN 512
                 *****************9876 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.05
                 GGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  82 enleelLaaadllqiprlkkaceeflkqs 110
                  ++  lL +a+ ++ ++l++ c +f++++
  EFC37948.1 526 IDIIGLLLLAQTYEANQLANFCLHFISTN 554
                 567889*****************999875 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.8   0.0   2.7e-22   9.7e-19       1     119 [.       6     119 ..       6     120 .. 0.87

  Alignments for each domain:
  == domain 1  score: 67.8 bits;  conditional E-value: 2.7e-22
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K+v+vGd++vGK++ll   ++++f e++ +t+  +++  +vt   g  n    +++++ +WDtaGqe+++ l+pl + + +++++++    + s++n+k
  EFC37948.1   6 KLVVVGDGAVGKSCLLIASTTNSFPEDYVPTVFDNYSA-NVT--YG--N----RNYNVGLWDTAGQEDYDRLRPLSYPGTDVFFVCFSmvnRASFANVK 95 
                 99******************************888865.442..22..2....46899***************************99776455778885 PP

                 .HHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  97 .eWlkelkkvagkspvilvgnkiD 119
                  +W+ el ++++++p+ilvg k D
  EFC37948.1  96 sKWIPELIHHCPDIPIILVGCKSD 119
                 37********************99 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   4.5e-08   0.00016      13     146 ..       3     139 ..       1     164 [. 0.80

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 4.5e-08
                 TEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEE.EEEEEE..TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHH.HHH CS
         Arf  13 kelrilllGLDnaGKtTilkklkleelvt.tvPTigfn.veelei..knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakee.Lka 106
                 ++l+++++G  + GK+ +l   +++++ +  vPT+  n + ++++  +n+++ +wD  Gqe   +l    ++ td+   +   ++r  +++ k++ + +
  EFC37948.1   3 NSLKLVVVGDGAVGKSCLLIASTTNSFPEdYVPTVFDNySANVTYgnRNYNVGLWDTAGQEDYDRLRPLSYPGTDVFFVCFSMVNRASFANVKSKwIPE 101
                 6789*****9999*******99999997659***98883568999556777888********9999999******999999999999999998773667 PP

                 HCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSS CS
         Arf 107 lleeeelkevallvlaNKqDlpealseeelrellgleelk 146
                 l++  +  ++++++++ K Dl ++++++ + ++  +e++ 
  EFC37948.1 102 LIH--HCPDIPIILVGCKSDLVSDADRDSIITQEMIEQMV 139
                 776..5789************9999988876666655543 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.5   0.0    0.0099        35       2      30 ..     487     515 ..     486     521 .. 0.89
   2 !   10.1   0.0   0.00019      0.67       2      48 ..     529     575 ..     528     579 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0099
        BACK   2 lgilefAeaysceeLaeaakefilknfee 30 
                 +g+l++A+ y+++ L+++++ fi kn+++
  EFC37948.1 487 VGLLSLANEYGMSGLTSMCEIFISKNIDK 515
                 78999*********************976 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00019
        BACK   2 lgilefAeaysceeLaeaakefilknfeevlkseeFleLskeqllel 48 
                 +g+l +A++y+ ++La+ + +fi +n   + +  e+  L+ e+l+++
  EFC37948.1 529 IGLLLLAQTYEANQLANFCLHFISTNYGPMKARREWELLTGENLKHV 575
                 78899************************************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (633 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1272  (0.0709465); expected 358.6 (0.02)
Passed bias filter:                      664  (0.037035); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.49
# Mc/sec: 3870.08
//
Query:       EFC37949.1  [L=432]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.8e-19   69.0   0.8    1.3e-17   64.1   0.2    2.4  2  BTB          BTB/POZ domain
    0.00083   19.3  94.7       0.16   11.9  36.4    3.2  2  Trypan_PARP  Procyclic acidic repetitive protein (PARP)
     0.0017   18.5   0.0       0.38   10.9   0.0    2.4  2  BACK         BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.1   0.2   2.1e-21   1.3e-17       2     110 ..      59     174 ..      58     175 .. 0.91
   2 ?    3.0   0.0     0.019   1.1e+02      82     110 ..     188     216 ..     181     217 .. 0.86

  Alignments for each domain:
  == domain 1  score: 64.1 bits;  conditional E-value: 2.1e-21
                 HHHHHHTTTS-EEEEETT...TEEEEE-HHHHHHH-HHHHHHHTST..TTTTCCCE......EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHH CS
         BTB   2 nelresgelcDvtlvvgd...gkefkahkavLaarSpyFkalftsk..eieessvs......eielddvepeafealLefiYtgeleitseenleelLa 89 
                 ++++++++ +Dv +v+ +    k f+ hk++L+a  ++F+++f+++  e   +s+       ei  ++   ++f+al+e++Y+++ +i+ e n++ lL+
  EFC37949.1  59 KKYFDKKTHSDVEIVFSTtdsSKNFQGHKLFLSANCDVFRTMFEGNfvE---HSSRqvdlsgEIGENENRISEFHALFEYLYSAHSTIN-ERNAVGLLS 153
                 5789999*********999999************************553...443334588999999*********************7.********* PP

                 HHHHHT-HHHHHHHHHHHHHH CS
         BTB  90 aadllqiprlkkaceeflkqs 110
                 +a+ + +  l+ +ce f++++
  EFC37949.1 154 LANEYGMSGLTSMCEIFISKN 174
                 *****************9876 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.019
                 GGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  82 enleelLaaadllqiprlkkaceeflkqs 110
                  ++  lL +a+ ++ ++l++ c +f++++
  EFC37949.1 188 IDIIGLLLLAQTYEANQLANFCLHFISTN 216
                 568889*****************999875 PP

>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -24.5  78.2         3   1.8e+04      73      83 ..     342     350 ..     289     398 .. 0.48
   2 !   11.9  36.4   2.7e-05      0.16      60     112 ..     367     419 ..     366     427 .. 0.62

  Alignments for each domain:
  == domain 1  score: -24.5 bits;  conditional E-value: 3
  Trypan_PARP  73 pepepepetep 83 
                  p+p+p+p  +p
   EFC37949.1 342 PKPKPKP--KP 350
                  0000000..00 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 2.7e-05
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepepepg 112
                  +p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p 
   EFC37949.1 367 KPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPN 419
                  45566666666666666666666666666666666666666666666666664 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.0    0.0037        22       2      30 ..     149     177 ..     148     183 .. 0.89
   2 !   10.9   0.0   6.4e-05      0.38       2      48 ..     191     237 ..     190     242 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0037
        BACK   2 lgilefAeaysceeLaeaakefilknfee 30 
                 +g+l++A+ y+++ L+++++ fi kn+++
  EFC37949.1 149 VGLLSLANEYGMSGLTSMCEIFISKNIDK 177
                 78999*********************976 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 6.4e-05
        BACK   2 lgilefAeaysceeLaeaakefilknfeevlkseeFleLskeqllel 48 
                 +g+l +A++y+ ++La+ + +fi +n   + +  e+  L+ e+l+++
  EFC37949.1 191 IGLLLLAQTYEANQLANFCLHFISTNYGPMKARREWELLTGENLKHV 237
                 78899************************************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1107  (0.0617435); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.83u 0.34s 00:00:01.17 Elapsed: 00:00:00.52
# Mc/sec: 2522.87
//
Query:       EFC37950.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      3e-31  108.9   0.0    3.4e-31  108.7   0.0    1.0  1  Abhydrolase_2  Phospholipase/Carboxylesterase
    1.5e-08   34.2   0.0    0.00054   19.3   0.0    2.0  2  Hydrolase_4    Serine aminopeptidase, S33
    1.8e-05   24.3   0.0      0.029   13.9   0.0    2.1  2  Peptidase_S9   Prolyl oligopeptidase family
    2.3e-05   24.3   0.0    0.00027   20.9   0.0    2.0  2  Abhydrolase_3  alpha/beta hydrolase fold
    0.00025   20.7   0.0    0.00036   20.2   0.0    1.2  1  DLH            Dienelactone hydrolase family
    0.00041   19.5   0.0    0.00057   19.0   0.0    1.1  1  Asp2           Accessory Sec system GspB-transporter
    0.00091   18.8   0.0       0.03   13.8   0.0    2.0  2  Esterase_phd   Esterase PHB depolymerase
     0.0039   16.9   0.0      0.008   15.9   0.0    1.5  1  FSH1           Serine hydrolase (FSH1)
     0.0097   15.8   0.2        1.5    8.7   0.0    2.1  2  BAAT_C         BAAT / Acyl-CoA thioester hydrolase C terminal
  ------ inclusion threshold ------
      0.026   13.2   0.0      0.042   12.5   0.0    1.3  1  AXE1           Acetyl xylan esterase (AXE1)
      0.031   13.9   0.7        4.5    6.8   0.3    2.1  2  Abhydrolase_1  alpha/beta hydrolase fold
      0.042   13.4   0.0      0.062   12.9   0.0    1.2  1  DUF2974        Protein of unknown function (DUF2974)
      0.083   12.5   0.0      0.085   12.5   0.0    1.2  1  Esterase       Putative esterase
       0.16   11.6   0.0       0.36   10.5   0.0    1.5  2  PGAP1          PGAP1-like protein


Domain annotation for each model (and alignments):
>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.7   0.0   2.7e-34   3.4e-31      64     216 ..       4     172 ..       1     173 [. 0.86

  Alignments for each domain:
  == domain 1  score: 108.7 bits;  conditional E-value: 2.7e-34
                    E-SS-B--SSTTS...-B-HHHHHHHHHHHHHHHHHHHHT.T--GGGEEEEEETHHHHHHHHHHHT-SS--SEEEEES---TTGGGTTTTS-GGG. CS
  Abhydrolase_2  64 paWfdlvglspek...kedeagikksaekleelidaelkk.gipssriiigGFSqGaalalylaltlpkklggivafsgalplsqklessatavt. 154
                     +W+++ +l+ e    +ed   +++ +ek+ +lid e+++ g++ sriii GFSqG+ +a y +lt++ klggi ++s++lpl+++l+s   +   
     EFC37950.1   4 KSWYNVKSLAVEGpdvNEDVPSMEACFEKITQLIDREINEfGVDPSRIIISGFSQGGSVAFYYGLTCKYKLGGIAILSSWLPLRTQLQSLLQNPEf 99 
                    58******998887556777788999************9846*******************************************99875443323 PP

                    ....GG-EEEEEEETT-SSS-HHHHHHHHHHHHTTS-.......GEEEEEETT--SS--HHHHHHHHHHHHHH CS
  Abhydrolase_2 155 ....kklpilqiHgeeDpvvplalgkaakevlkkllk.......kvelksyeglaHsideeemqdikeflkkl 216
                         k+pi+  Hg+ D+v+++  g  +k +l + +        +ve+++y+g++Hs+ eee++d+  f+ k+
     EFC37950.1 100 dfknCKTPIFIAHGDADNVLEYKYGVSSKDYLVNQVLnqeggseHVEFHTYKGMGHSSNEEELRDLGRFIGKV 172
                    333469************************9987553356677789***********************9875 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.0   2.3e-05     0.029      51     117 ..      22      90 ..      17      97 .. 0.85
   2 !   19.3   0.0   4.2e-07   0.00054     186     234 ..     100     157 ..      87     161 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.3e-05
  Hydrolase_4  51 hvpsfddyvdDlaafvekvkeehpel..plfllGhSmGGliallyllrypdkvaglilsaPalkikakl 117
                  +vps++ + + + +++++  +e +    ++++ G S GG +a+ y+l+++ k+ g+ + +++l ++++l
   EFC37950.1  22 DVPSMEACFEKITQLIDREINEFGVDpsRIIISGFSQGGSVAFYYGLTCKYKLGGIAILSSWLPLRTQL 90 
                  578888888889999988888887776789************************999999999888764 PP

  == domain 2  score: 19.3 bits;  conditional E-value: 4.2e-07
  Hydrolase_4 186 raakitlPllllhGeaDkvvdpeas.........relyerlgskdktlklypglyHel 234
                  + ++ ++P+++ hG+aD+v +++           + l ++ gs+++++++y+g+ H+ 
   EFC37950.1 100 DFKNCKTPIFIAHGDADNVLEYKYGvsskdylvnQVLNQEGGSEHVEFHTYKGMGHSS 157
                  567788****************99999******999999*****************85 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0   0.00091       1.2      43      77 ..      28      62 ..      25      66 .. 0.85
   2 !   13.9   0.0   2.2e-05     0.029     138     209 ..     102     173 ..      88     174 .] 0.82

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00091
                  HHHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHH CS
  Peptidase_S9 43 nefdDfiaaaealakegyvdserlaitGgSyGGyl 77
                  ++f+ + + ++  ++e+ vd++r++i G S GG +
    EFC37950.1 28 ACFEKITQLIDREINEFGVDPSRIIISGFSQGGSV 62
                  567777788888899999***************75 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 2.2e-05
                   GG-----EEEEEEETT-SSS-THHHHHHHHHHH......--S-S.EEEEEETTS-SSTTSSHHHHHHHHHHHHHHHHHC CS
  Peptidase_S9 138 dnvkaypplLlihGlaDdrvppaealklvaaLq......kkgkn.vlllifpdegHgvgkprakveelarllaFlkeal 209
                   +n   ++p+++ hG+aD+   ++ ++   + L       + g + v+++++++ gH     +++ eel++l +F+ ++l
    EFC37950.1 102 KN--CKTPIFIAHGDADNVLEYKYGVSSKDYLVnqvlnqEGGSEhVEFHTYKGMGH-----SSNEEELRDLGRFIGKVL 173
                   45..79*******************99999999899998778889***********.....455677777777776665 PP

>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.0   2.1e-07   0.00027      49     120 ..      26      99 ..      23     139 .. 0.73
   2 ?    1.6   0.1      0.16   2.1e+02     195     208 ..     143     156 ..     126     158 .. 0.82

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 2.1e-07
                    HHHHHHHHHHHHHTHH.HHTETTCEEEEEEETHHHHHHHHHHHHHHHTT---EEEEEEESE.-SST.SSTTSHHH CS
  Abhydrolase_3  49 vedalaalrwlaeqaw.elgadpsrivlaGdSaGGnlaaavalrardegepkvagqvliyP.vtdl.ertesesi 120
                    +e +++ + +l +++  e+g+dpsri++ G S GG  a +  l ++ +   ++a +  + P  t+l +  +++++
     EFC37950.1  26 MEACFEKITQLIDREInEFGVDPSRIIISGFSQGGSVAFYYGLTCKYK-LGGIAILSSWLPlRTQLqSLLQNPEF 99 
                    68899999999999999*************************999997.66677777777742222333344444 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.16
                    --EEEEEETTEETT CS
  Abhydrolase_3 195 vevelieyegmvHg 208
                    ++ve++ y+gm H+
     EFC37950.1 143 EHVEFHTYKGMGHS 156
                    689**********6 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   2.8e-07   0.00036      92     191 ..      44     159 ..      22     165 .. 0.74

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 2.8e-07
         DLH  92 vpevstkkvgvvGfCmGGalalllaaev.pevdaavafYG.........lspekeleeaakikapilalfgeeDefipade.....vekleealkaan. 174
                 ++ v+++++ + Gf  GG +a+++      ++ + ++            + ++++  + ++ k+pi++ +g++D++ + +         +++ l +++ 
  EFC37950.1  44 FG-VDPSRIIISGFSQGGSVAFYYGLTCkYKLGGIAILSSwlplrtqlqSLLQNPEFDFKNCKTPIFIAHGDADNVLEYKYgvsskDYLVNQVLNQEGg 141
                 44.7789***************998777344555443333555**999999999*********************998765555432334444544432 PP

         DLH 175 .vdlelkvYpgagHaFan 191
                   ++e++ Y+g gH+ ++
  EFC37950.1 142 sEHVEFHTYKGMGHSSNE 159
                 267999********9665 PP

>> Asp2  Accessory Sec system GspB-transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.0   4.4e-07   0.00057     337     374 ..      31      68 ..      22      79 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 4.4e-07
        Asp2 337 ekiikiikekleeLgfeeeqlilsGlSMGtfgalyYga 374
                 eki++ i+++++e+g + + +i+sG S G   a+yYg 
  EFC37950.1  31 EKITQLIDREINEFGVDPSRIIISGFSQGGSVAFYYGL 68 
                 689*********************************95 PP

>> Esterase_phd  Esterase PHB depolymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   2.4e-05      0.03      81     126 ..      33      78 ..      27      88 .. 0.83
   2 ?    3.0   0.0     0.048        62     170     198 ..     106     138 ..     101     146 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.4e-05
  Esterase_phd  81 vvalvdalvdehrvdaarvyvaGlsaGaaladllalhypdvfaava 126
                   ++ l+d  ++e +vd++r+ ++G+s G+++a   +l+   ++  +a
    EFC37950.1  33 ITQLIDREINEFGVDPSRIIISGFSQGGSVAFYYGLTCKYKLGGIA 78 
                   788999999*********************9888877666665555 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.048
  Esterase_phd 170 lpalvvqGdadtvvavk....naeslvvalrrl 198
                    p ++ +Gdad+v++ k      + lv ++ + 
    EFC37950.1 106 TPIFIAHGDADNVLEYKygvsSKDYLVNQVLNQ 138
                   5899*********98762111345566666555 PP

>> FSH1  Serine hydrolase (FSH1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   6.2e-06     0.008      71     191 ..       4     143 ..       1     155 [. 0.70

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 6.2e-06
        FSH1  71 raWfrkkde.......kneyegleesldavkdyike......ngp.fdGiiGFSqGaalaallaslleellkeashpslkfailvsGfkleepkyeeyy 155
                 ++W++ k         ++++ ++e +++++++ i++        p    i GFSqG+ +a ++  + + +l         +ail s   l +++ +++ 
  EFC37950.1   4 KSWYNVKSLavegpdvNEDVPSMEACFEKITQLIDReinefgVDPsRIIISGFSQGGSVAFYYGLTCKYKLG-------GIAILSSWLPL-RTQLQSLL 94 
                 678888777788888889999999999999999998444444223233467**********99888887665.......46776665555.55566655 PP

        FSH1 156 eedki.....qtptLhvlGelDtvvdee....rseaLaeafkns....s 191
                 +++++     +tp++  +G++D+v + +       +L++++ n+    +
  EFC37950.1  95 QNPEFdfkncKTPIFIAHGDADNVLEYKygvsSKDYLVNQVLNQeggsE 143
                 4444444445**************9987666567788888888744432 PP

>> BAAT_C  BAAT / Acyl-CoA thioester hydrolase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0     0.011        14       5      43 ..      29      70 ..      26      82 .. 0.77
   2 !    8.7   0.0    0.0012       1.5     107     161 ..      97     155 ..      79     158 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.011
                HHHHHHHHHHCST...TB--SSEEEEEETHHHHHHHHHHHHS CS
      BAAT_C  5 YFeeainyllrhp...kvkkdkigllGiSkGgelalllasfl 43
                +Fe++ + + r+     v  ++i + G S+Gg +a++ + + 
  EFC37950.1 29 CFEKITQLIDREInefGVDPSRIIISGFSQGGSVAFYYGLTC 70
                788888888765411168999**************9976554 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0012
                 CB--GGG--SEEEEEEETT-SSS-......HHHHHHHHHHHHHCTT--.--EEEEETTB-S CS
      BAAT_C 107 alipvekakgpillvvgedDknwp......SkesaekaserLkkagkkvevqlltYpkaGH 161
                   +++ + k+pi ++ g  D++++      Sk++   + + L+++g + +v+ +tY++ GH
  EFC37950.1  97 PEFDFKNCKTPIFIAHGDADNVLEykygvsSKDY--LVNQVLNQEGGSEHVEFHTYKGMGH 155
                 46888999************99872222113333..3788899999999************ PP

>> AXE1  Acetyl xylan esterase (AXE1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   3.3e-05     0.042     155     189 ..      30      64 ..      19      72 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.3e-05
                 HHHHHHHHHHHHTSTTEEEEEEEEEEETHHHHHHH CS
        AXE1 155 flDavrlveivaslpevDeeRvavlGasqGGalal 189
                 f  + +l++   +   vD++R+ + G sqGG++a 
  EFC37950.1  30 FEKITQLIDREINEFGVDPSRIIISGFSQGGSVAF 64 
                 5667778887778888****************986 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.3    0.0035       4.5      73     106 ..      49      82 ..      45      99 .. 0.78
   2 ?    6.2   0.0    0.0055         7     206     250 ..      92     144 ..      81     162 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0035
                    SSEEEEEETHHHHHHHHHHHHHGGGEEEEEEESE CS
  Abhydrolase_1  73 dkltlvGhSmGGmialayaaeyperVkalvllga 106
                     ++++ G+S+GG +a++y +  + +  +++ l++
     EFC37950.1  49 SRIIISGFSQGGSVAFYYGLTCKYKLGGIAILSS 82 
                    578899************9988877777777777 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0055
                    C........THHHHSEEEEEEETTCSSSCHHHHHHHHHCHTSEEEEEEETCSS CS
  Abhydrolase_1 206 e........lknvlaptlvisgtsDplvppkaledlaqllpkkrlvvisdagH 250
                    +        +kn + p+++ +g+ D++  +k+++ +++ l ++ l ++ +++H
     EFC37950.1  92 SllqnpefdFKNCKTPIFIAHGDADNVLEYKYGVSSKDYLVNQVLNQEGGSEH 144
                    23335667789999*******************99999944434444444444 PP

>> DUF2974  Protein of unknown function (DUF2974)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   4.8e-05     0.062      84     106 ..      42      71 ..      18      81 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.8e-05
     DUF2974  84 g.......kiylgGhSkGGnlAvyaamnae 106
                 +       +i+++G+S+GG++A+y  ++++
  EFC37950.1  42 NefgvdpsRIIISGFSQGGSVAFYYGLTCK 71 
                 334455547***************877766 PP

>> Esterase  Putative esterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   6.7e-05     0.085     109     149 ..      43      83 ..      28     156 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 6.7e-05
                 HCSEECCCEEEEEETHHHHHHHHHHHCSTTTCCEEEEES-- CS
    Esterase 109 nfrtapdgravaGqSmGGlgALilalkhpdrFgsvssfSpi 149
                 +f ++p++  + G+S+GG++A +++l+   + g ++ +S  
  EFC37950.1  43 EFGVDPSRIIISGFSQGGSVAFYYGLTCKYKLGGIAILSSW 83 
                 68888888999***************988888888888855 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00028      0.36      54     106 ..       8      64 ..       3      93 .. 0.84
   2 ?   -2.1   0.0         2   2.5e+03      26      51 ..     125     150 ..     104     154 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00028
       PGAP1  54 neelsaldGrtlldqaeylndaIkyIlsly....sssekeptsviliGHSmGGivar 106
                 n +  a++G  +++    ++ + ++I++l     ++   +p+++i+ G S GG va 
  EFC37950.1   8 NVKSLAVEGPDVNEDVPSMEACFEKITQLIdreiNEFGVDPSRIIISGFSQGGSVAF 64 
                 667789999999999999************7777777789***************95 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2
       PGAP1  26 eaaeayqelrkllknqnkkeldfftv 51 
                 +++++y  ++ l ++  +++++f+t+
  EFC37950.1 125 VSSKDYLVNQVLNQEGGSEHVEFHTY 150
                 44556777777777777778888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       348  (0.0194099); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1013.54
//
Query:       EFC37951.1  [L=1750]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-20   73.7 180.4     0.0032   17.8   6.4   12.7 12  EGF_2         EGF-like domain
    2.2e-13   49.8  15.3    2.2e-13   49.8  15.3    4.5  4  REJ           REJ domain
     0.0073   16.2   0.8     0.0073   16.2   0.8    2.3  2  Orthoreo_P10  Orthoreovirus membrane fusion protein p10
  ------ inclusion threshold ------
       0.11   12.7   0.5       0.17   12.0   0.5    1.2  1  DUF3180       Protein of unknown function (DUF3180)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6  12.4   1.5e-05     0.066       4      32 .]       5      32 ..       2      32 .. 0.85
   2 !    9.0   7.2   0.00039       1.8       5      32 .]      45      72 ..      41      72 .. 0.78
   3 !   15.3  11.4   4.3e-06     0.019       4      32 .]      84     111 ..      81     111 .. 0.86
   4 !    7.0   9.4    0.0018       7.8       4      32 .]     122     150 ..     116     150 .. 0.84
   5 !   12.0   6.2   4.6e-05      0.21       4      32 .]     162     189 ..     160     189 .. 0.91
   6 !   10.7  10.1   0.00012      0.53       5      32 .]     202     228 ..     194     228 .. 0.89
   7 !   17.8   6.4   7.1e-07    0.0032       6      32 .]     242     267 ..     237     267 .. 0.89
   8 !   16.0   5.3   2.6e-06     0.012       5      32 .]     280     306 ..     276     306 .. 0.90
   9 !   17.3   8.5     1e-06    0.0046       5      32 .]     319     345 ..     315     345 .. 0.90
  10 !   12.6  11.9   2.9e-05      0.13       1      32 []     593     627 ..     593     627 .. 0.88
  11 ?    0.8   0.9      0.14   6.4e+02      23      32 .]     630     639 ..     629     639 .. 0.94
  12 !    9.6   3.8   0.00027       1.2       8      32 .]    1189    1210 ..    1183    1210 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.5e-05
       EGF_2  4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                ++  C+g+G+C++ +  C+C+ gy+G  C
  EFC37951.1  5 NSGVCNGRGHCIDYN-HCSCNYGYSGIGC 32
                4789*******8444.8***********9 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00039
       EGF_2  5 deiCgghGtCvnqcGqCdCdsgyq.GktC 32
                +  C+g+GtC  +   C C+++y+ + +C
  EFC37951.1 45 SRVCSGRGTCSLSD-SCICQNHYTfQQDC 72
                678*******9344.6***9999877777 PP

  == domain 3  score: 15.3 bits;  conditional E-value: 4.3e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C+ hG+C++  + C C+ +y+G++C
  EFC37951.1  84 SSNVCSSHGQCISY-NHCNCSENYYGNNC 111
                 3799*******944.48************ PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0018
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C g G C +  + C C+ +y+G +C
  EFC37951.1 122 NdSSVCFGKGNCSDY-NTCNCELNYYGLDC 150
                 46889*******744.49***********9 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 4.6e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+ +G+Cv++   C C  +y+G+ C
  EFC37951.1 162 NSSVCSSRGSCVAFD-LCNCTENYFGDWC 189
                 4789********999.9*********988 PP

  == domain 6  score: 10.7 bits;  conditional E-value: 0.00012
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g G+Cvn+   C C+s  +G +C
  EFC37951.1 202 ASVCSGKGVCVNFD-TCTCQSDAYGSNC 228
                 678********999.9***********9 PP

  == domain 7  score: 17.8 bits;  conditional E-value: 7.1e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ +G C n+  +C C+++y+G++C
  EFC37951.1 242 NVCSSRGACLNTD-RCNCSDNYFGNYC 267
                 68*******8777.9************ PP

  == domain 8  score: 16.0 bits;  conditional E-value: 2.6e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g G C+++   C+C++g++G+ C
  EFC37951.1 280 SIVCSGMGDCIDFD-MCQCQTGFYGDVC 306
                 568********999.***********99 PP

  == domain 9  score: 17.3 bits;  conditional E-value: 1e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G C +++  C+C+s+++G +C
  EFC37951.1 319 ETVCSSNGNCTQLN-HCECNSNFTGIQC 345
                 678*******9666.9************ PP

  == domain 10  score: 12.6 bits;  conditional E-value: 2.9e-05
       EGF_2   1 CsasdeiCgghGtC.vnqcGqCdC.....dsgyqGktC 32 
                 C+  +++C++hG C    +G+C+C     +  ++G +C
  EFC37951.1 593 CEK-KLNCSNHGDClY--TGKCRCytddsNGYWSGESC 627
                 666.588*******55..8********99999****99 PP

  == domain 11  score: 0.8 bits;  conditional E-value: 0.14
       EGF_2  23 CdsgyqGktC 32 
                 C +g++G++C
  EFC37951.1 630 CLFGFYGDSC 639
                 99******** PP

  == domain 12  score: 9.6 bits;  conditional E-value: 0.00027
       EGF_2    8 CgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cg +G+ +   G C+C++gy G +C
  EFC37951.1 1189 CG-NGVEI--SGICKCFDGYVGQYC 1210
                  54.35555..789************ PP

>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -7.2   6.0         4   1.8e+04     169     169 ..     438     438 ..     317     552 .. 0.66
   2 !    7.6   0.1   0.00031       1.4      87     141 ..     647     696 ..     643     740 .. 0.66
   3 !   49.8  15.3   4.9e-17   2.2e-13      44     424 ..     801    1139 ..     766    1157 .. 0.79
   4 ?   -0.8   0.1      0.11     5e+02     177     210 ..    1558    1591 ..    1480    1599 .. 0.84

  Alignments for each domain:
  == domain 1  score: -7.2 bits;  conditional E-value: 4
         REJ 169 l 169
                 l
  EFC37951.1 438 L 438
                 1 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00031
         REJ  87 IkGGssrvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnp 141
                 I  +++ v +  +++ +dG +Sy  d  d     l+++W+  +s++ ++ + + +
  EFC37951.1 647 IIAATEEVYSSCDDILIDGRSSYSFDGTD-----LNFYWKLIDSDTLQEVSSNHS 696
                 444588899999*************8885.....99*********7666555542 PP

  == domain 3  score: 49.8 bits;  conditional E-value: 4.9e-17
         REJ   44 ippsfLpygtyvflltvslsgeps..leatdiikvrvepspLvavIkGGssrvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnn 138 
                  ip+ +L yg+++f+++v+    +s   +at++  +++++++L   +   +      ++nl++   +  + + d++     +++W+c +++     n 
  EFC37951.1  801 IPS-MLNYGKNSFTFQVTAYYPSSpkFNATQTLIIKTKSTDLSLDLIQTT--ATETSTNLVVKFVD-LELNGDEE-----TWKWSCLDNN-----NT 883 
                  444.6******999999987655555****************99876533..44455777776433.33333432.....479***6666.....55 PP

         REJ  139 dnpllnidpealsgtllssstssltfpaselvanl..tynftltvskrsrksasteqtilvvdgepplvsiecisncngkvnpndrlvllasclnca 233 
                    +l+ +d ++ +          +tf++s + +++   +++tl vsk+    +  + ti   +  pp+vsi  ++     v p ++l l++   n +
  EFC37951.1  884 KLMLFLSDISQRK-------VDDITFDSSIFGSEIpnSIELTLQVSKSYN-RSIEKSTIIYFNAIPPIVSIVYTEPSTSFVLPGQQLFLQTFIANNQ 972 
                  5555555555555.......77999999999998887899*******997.799999*********************************9966665 PP

         REJ  234 kdlkdvtfeWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkks..glasisfkvnepPtgGtcsvtPlegvale 328 
                  +  +++t+                 ++ + +   +++ L i++++L++g++ ++t+   +++++++   +++++f v + P  ++cs+tP+ g+ale
  EFC37951.1  973 Q--SNLTVF----------------LNGQVIGVYDKTGLIIDTSNLEQGSQNTITI--QSYDPATGkiFTTTYTFNVASNPKPCKCSITPSIGTALE 1049
                  3..334422................4677777788889******************..7777777776899************************** PP

         REJ  329 taftvrCqgwtDkdqPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarv.svsltitVkppavnns.tieell 423 
                  t+f++ C + + +     Y++  +++++sg    l++ +     s++LP ++   +++vt ++ + D+   ++ +v  ++tV++p+v++   +++l+
  EFC37951.1 1050 TDFDFYCANCKTDII--DYQY-GFVDDKSGVKISLRKEEVY---SSKLPAPYY--GSTVTCYFDIIDTSTNAYsTVYVNVTVEAPTVSTIdQLQNLV 1138
                  *****9988755554..5888.7788888877777766666...9****9999..9************999998*************9885555554 PP

         REJ  424 e 424 
                  e
  EFC37951.1 1139 E 1139
                  4 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 0.11
         REJ  177 ftltvskrsrksasteqtilvvdgepplvsieci 210 
                  +tl+   r ++++++  ++ ++ ++++++++e  
  EFC37951.1 1558 ITLICVRRRKRKQQARRMVMMEASKIQDIILENR 1591
                  5565555555599****************99865 PP

>> Orthoreo_P10  Orthoreovirus membrane fusion protein p10
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.5   2.3         4   1.8e+04       4      30 ..      83     109 ..      81     112 .. 0.78
   2 !   16.2   0.8   1.6e-06    0.0073       7      87 ..    1500    1581 ..    1496    1588 .. 0.67

  Alignments for each domain:
  == domain 1  score: -5.5 bits;  conditional E-value: 4
  Orthoreo_P10   4 mssgscnkavsvfgnvhcqaakntagg 30 
                    ss+ c+     +   hc++++n  g 
    EFC37951.1  83 NSSNVCSSHGQCISYNHCNCSENYYGN 109
                   5677788888888899***99998775 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 1.6e-06
  Orthoreo_P10    7 gscnkavsvf.gnvhcqaakntaggdlq.atssliaywpylaagggliviilllallycckakvkadavrsvfrrelvalssg 87  
                    ++c+ +vs+   +++c++ + t    +q at +  +y  y+a+gg   vi+ll++++    +   + + r+   r +v ++ +
    EFC37951.1 1500 SNCE-IVSIQeKSIKCRCKRFTNVFVIQtATITTQSYGQYVAIGGATFVILLLISIITLITLICVRRRKRKQQARRMVMMEAS 1581
                    4554.4555416899999999999988845666778*********99888887776655555544444555555555555555 PP

>> DUF3180  Protein of unknown function (DUF3180)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.5   3.7e-05      0.17      12      65 ..    1527    1579 ..    1519    1584 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 3.7e-05
     DUF3180   12 gwllvrvsygslpplpwlaavvllvlavvelvlAlqvrrrirgrpgarqleplt 65  
                  ++ ++  syg+++++   + v+ll++++++l++ + vrrr r++ +ar++ ++ 
  EFC37951.1 1527 TATITTQSYGQYVAIGGATFVILLLISIITLITLICVRRRKRKQ-QARRMVMME 1579
                  33333449*********************************888.566666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1750 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1201  (0.0669864); expected 358.6 (0.02)
Passed bias filter:                      286  (0.0159518); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.09u 0.35s 00:00:01.44 Elapsed: 00:00:00.54
# Mc/sec: 9681.55
//
Query:       EFC37952.1  [L=602]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.31   11.3   2.7        4.2    7.7   0.1    3.0  4  Phi-29_GP4  Phi-29-like late genes activator (early protein G


Domain annotation for each model (and alignments):
>> Phi-29_GP4  Phi-29-like late genes activator (early protein GP4)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.1   0.00023       4.2      47     115 ..     101     171 ..      38     174 .. 0.86
   2 ?   -2.9   0.0      0.42   7.6e+03      44      71 ..     265     293 ..     242     305 .. 0.73
   3 ?    0.1   0.0     0.053   9.5e+02      53      86 ..     514     547 ..     502     562 .. 0.84
   4 ?    2.0   0.0     0.013   2.4e+02      15      54 ..     541     580 ..     530     588 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00023
                 HHHHHH.HTT---S---HHHHHH.HHHHHH-TS---EEETTEEE-HHHHHHHHHHHTTSSS----EEES-- CS
  Phi-29_GP4  47 kfnkki.ervavtpwnmdmladi.tfysevekrgfhawlkgdnatwrevhvyalrimtkpntldwsriqkp 115
                 k+n+k+ e +a   wn+ +      fy ++    +   lk dn t  ++hv  +   + p+ +  s i+kp
  EFC37952.1 101 KVNEKLdEMIANGDWNFTLRKPFqQFYMKMTDLNIDIPLKLDNLTGLQMHVMLIDHWAYPEEFYLSAIKKP 171
                 56666626789999***99887537********************************************99 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.42
                 HHHHHHHHHHT.T---S---HHHHHHHHH CS
  Phi-29_GP4  44 yrkkfnkkier.vavtpwnmdmladitfy 71 
                 y  +f+  ie+ v v    + ml  i +y
  EFC37952.1 265 YDPEFDTLIEHlVIVLVMSLHMLQGIRYY 293
                 56677777776345667788888888887 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.053
                 HTT---S---HHHHHHHHHHHH-TS---EEETTE CS
  Phi-29_GP4  53 ervavtpwnmdmladitfysevekrgfhawlkgd 86 
                 +r  +t ++m++l   tf ++  k  +  +lk  
  EFC37952.1 514 KRFLITEFKMELLEIYTFLTKYPKSTVEEYLKIS 547
                 688899**************99999999999865 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.013
                 -SEEEE-SSEEEEESSHHHHHHHHHHHHHHHHHHHHHHHT CS
  Phi-29_GP4  15 seyvasntdvtfffsselylnkfldgyqeyrkkfnkkier 54 
                  ey+    + t+f+++ l   + +d yqe  +++ +  +r
  EFC37952.1 541 EEYLKISPQTTLFVNTHLRKRQDVDTYQEVSRQLLEIFNR 580
                 6888889999*******************98887666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (602 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       913  (0.0509231); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.21s 00:00:00.71 Elapsed: 00:00:00.42
# Mc/sec: 4318.06
//
Query:       EFC37953.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.5e-20   71.0   0.1    1.2e-18   67.3   0.1    2.1  2  adh_short     short chain dehydrogenase
    1.2e-12   48.0   0.0    8.9e-12   45.1   0.0    2.2  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    0.00061   19.3   0.0    0.00081   18.9   0.0    1.2  1  Epimerase     NAD dependent epimerase/dehydratase family


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.3   0.1     2e-22   1.2e-18       1     137 [.      40     189 ..      40     196 .. 0.83
   2 ?    1.4   0.0     0.031   1.9e+02     148     188 ..     217     268 ..     207     271 .. 0.61

  Alignments for each domain:
  == domain 1  score: 67.3 bits;  conditional E-value: 2e-22
                 SEEEEESTTS.HHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT.........TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS- CS
   adh_short   1 kvvlvtGass.GIGraiakelakeGakvvvvdrseekleevakelkee.........gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitg 89 
                 +vvl+tGas+ GIG++++k+l+  Ga+v v  r+ e+  e ++el++e           k++++++ + d e+v+++     +k+++ld+L+nNAG+  
  EFC37953.1  40 QVVLITGASKgGIGYETVKALYCLGATVCVSVRNLERGLEEMDELEREcksmnrnlnLGKIIVMKMELDDLESVREFCHSFLQKFDRLDILINNAGV-- 136
                 69******9747******************888877776666666666543333233356*************************************.. PP

                 -SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHH......HCTTEEEEEEEEG CS
   adh_short  90 sgpfselseeewervievNltgvflltravlpaml......kqssGrIvnvsSv 137
                  ++ s ls+++ e  ++vN  g f+l++  l+ ++       +++ +I+ vsS 
  EFC37953.1 137 YSSPSTLSKQNLEIHFAVNHLGHFMLVHF-LKSLIqqtsvaHNKECKIISVSSL 189
                 466678999***************99865.5555557778889999*****996 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.031
                 HHHHHHHHHHHHHHHHH....HHHGGGT.......EEEEEEEESSBSSHHHH CS
   adh_short 148 aYsAsKaavagltrsla....kelaptg.......irvnavaPGlvdTdmak 188
                 aY+ sK     +++sla    +e a+++       i + +++PG v+T++ +
  EFC37953.1 217 AYGFSKLCNLLFIKSLArqfeNETATSNslkpvakIGCYSLHPGTVSTNVFR 268
                 6777776555555555500004555555666666677777888888887765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.1   0.0   1.5e-15   8.9e-12       1     138 [.      46     197 ..      46     302 .. 0.88

  Alignments for each domain:
  == domain 1  score: 45.1 bits;  conditional E-value: 1.5e-15
                   TTT.TSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTT......SEE.....EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCS CS
  adh_short_C2   1 Gaa.sgIGraiAkalaeeGaevvltdlneea.kkrveelaeelg......aev.....lecDVtdeeqvealveevvekfgklDilvnnagiapklk 84 
                   Ga   gIG++++kal   Ga+v+++ +n e+  ++++el++e++      + +     +++   d e+v+++     +kf++lDil+nnag+  +  
    EFC37953.1  46 GASkGGIGYETVKALYCLGATVCVSVRNLERgLEEMDELERECKsmnrnlN-LgkiivMKMELDDLESVREFCHSFLQKFDRLDILINNAGVYSS-- 139
                   77778***********************99999999999999885543330.144467***********************************99.. PP

                   S-GGGH-HHHHHHHHHHHTHHHHHHHHHHHHHCTSC.......CEEEEEEEGGGTSBSTTT CS
  adh_short_C2  85 gpfletsreefdraldvnlyslfllakaalplmkeg.......gsivnlssvgaervvpny 138
                       ++s+++++  ++vn  + f+l++ ++ l++++        +i+ +ss+g   v  n 
    EFC37953.1 140 --PSTLSKQNLEIHFAVNHLGHFMLVHFLKSLIQQTsvahnkeCKIISVSSLGHIAV-RNK 197
                   ..5789********************9999977776666667789******966544.443 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   1.4e-07   0.00081       1     162 [.      42     238 ..      42     270 .. 0.78

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 1.4e-07
                 EEEETTT.SHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC................EEEE--TT-HHHHHHHHHH....H.T-SEEEE--S.--- CS
   Epimerase   1 ilVtGat.GfiGsalvkallekgyevigldrlssasntarledl................elveldltdrsalerlfke....e.qpdavihlAa.vgg 76 
                 +l+tGa+ G iG  +vkal   g +v +  r+ +++  ++ ++l                 +++++l d +++++++++    + + d+ i+ A+ +++
  EFC37953.1  42 VLITGASkGGIGYETVKALYCLGATVCVSVRNLERG-LEEMDELerecksmnrnlnlgkiIVMKMELDDLESVREFCHSflqkFdRLDILINNAGvYSS 139
                 68999855999*******999998854444442333.23333335789999999999*99999999999999988765322215689********8888 PP

                 HHHHHHSHHHHHH.HHTHHHHHHHHHHH........HHTCT.EEEEEEE.GGGGTSCSSSS..BSTCSTTS----SSHHHHHHHHHHHHHHHHHHHHT- CS
   Epimerase  77 vaassedpadfie.knlqgtlnlleaar........kagvk.rllflsS.sevYGkdaeqp..keettltgplkpnspYaaaKlageklveayaaqygl 162
                 +++ s+++ ++    n  g   l++ ++        +++ + +++ +sS  ++  ++++q   ++e++ t +  p  +Y+ +Kl+    ++++a+q++ 
  EFC37953.1 140 PSTLSKQNLEIHFaVNHLGHFMLVHFLKsliqqtsvAHNKEcKIISVSSlGHIAVRNKDQLlfTKEKLSTPQSSPMFAYGFSKLCNLLFIKSLARQFEN 238
                 888777777764459*************99999888677778*******777777777763457777755555**********************9964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       463  (0.0258241); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2175.22
//
Query:       EFC37954.1  [L=584]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (584 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.41
# Mc/sec: 4239.18
//
Query:       EFC37955.1  [L=536]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-74  251.2   0.0    2.1e-74  251.0   0.0    1.0  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  251.0   0.0   1.2e-78   2.1e-74       6     459 ..      69     527 ..      66     531 .. 0.89

  Alignments for each domain:
  == domain 1  score: 251.0 bits;  conditional E-value: 1.2e-78
                 EHHCCHCHHHHTTTCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHH CS
        p450   6 plplvgnllqlgrkeelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltp 104
                 ++p++   l +g ++++ e ++k+  +  ++ +l + ++++v +s+ +++ke+ i+k+++f++   + +++       g++++  ++e wk++ ++++p
  EFC37955.1  69 RIPFIAPYLYFGPTDKMLELMDKIGDSETKTTSLSMINENSVWISDKDMIKELTITKASDFEK--PKDFFDA--INIFGENLASVQSENWKRHFKVCNP 163
                 689999999999999******************************************999999..3445554..3799********************* PP

                 HHTSHSTT.THHHHHHHHHHHHHHHHHCCCCHCS.EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSH.HHHHHHHHHHHHHHHHCHHHHCCCCCHHHTC CS
        p450 105 tltsfgkl.sleelveeeaedlveklrkkagess.elditellskaaldvigsilFgarfdlledek.lselvkaveelssllskssvqllllfpllky 200
                  +  + +l  + ++  ++++ l ++++k  ++ + ++  +++ s+ +ldv+g+  Fg  f++ ++++  +++ +a e  ++   + +  ++l+ + ++y
  EFC37955.1 164 GFSPK-NLeYVCKVAAQSSDLLFNEWKKVIEKDGkVVLQVTDYSDLTLDVLGKAGFGFDFGIFTSDEtGKKFRAALEYTITYGIA-VRGFILPASKFLY 260
                 ***99.887899999******************97666678899*****************665444256777777777665544.5567777777889 PP

                 CSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC..........SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        p450 201 lptkllrklkeavkklkdlldklieerretldsa..........kksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeL 289
                  +   +  l + +++++++l+++ie rr++++++           + + d l++l++a  + ++   lsd el+ + + l +aG++Tts+ l+w+ ye+
  EFC37955.1 261 NIVANYTGLTDYCDFMAKILNNVIETRRKEIKEReqdpnandkrGDVPCDILSLLVEAN-MTENA--LSDGELMSNSFILALAGHETTSTLLQWVSYEI 356
                 99999999*******************************99887557889999999995.66665..******************************** PP

                 HHSHHHHHHHHHHHHHHCCTTTT-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGG CS
        p450 290 aknPevqeklreEidevlgdkreptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRF 388
                  k+Pe+ +kl++E+de l+++  ptydd+ kl y++ vi E+LR hp+v + ++ + +k ++i+ ++ipkGt+v  ++ ++h++++++++P +F+p+RF
  EFC37955.1 357 SKRPEILKKLQQEVDEKLQGR-DPTYDDFPKLDYVNGVIMEILRVHPPVSTVIKVVSKKSTKIGKFDIPKGTIVRAFMEHTHYREDYWKDPYTFNPDRF 454
                 ******************884.6***************************7776666669*************************************** PP

                 B-TTS.CTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSC.SSEEESSSS CS
        p450 389 ldekg.nskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileks.glllppkpi 459
                  d +  ++ ++ f +lPF+ G R CiG r+  me  ++la+l+q+++++l +++++ p   ++ ++ +p+++ 
  EFC37955.1 455 GDFESrEKIQHTFMWLPFSSGNRKCIGYRFSLMEGCIILAKLVQHYDFSLLNDEKVDPVTTRTlSVNRPSPNM 527
                 9977766779******************************************999999999985555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (536 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1016  (0.056668); expected 358.6 (0.02)
Passed bias filter:                      830  (0.0462937); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.24s 00:00:00.73 Elapsed: 00:00:00.39
# Mc/sec: 4079.84
//
Query:       EFC37956.1  [L=1566]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-15   57.7   0.2    4.4e-15   55.8   0.2    2.2  1  PAS_9       PAS domain
    8.4e-06   25.8   0.0    2.2e-05   24.4   0.0    1.8  1  PAS         PAS fold
     0.0019   17.7   1.4     0.0025   17.3   0.1    1.9  2  HNOBA       Heme NO binding associated
  ------ inclusion threshold ------
      0.061   13.6   0.0       0.13   12.5   0.0    1.6  1  PAS_4       PAS fold
       0.07   13.2   0.0       0.18   11.9   0.0    1.6  1  PAS_8       PAS domain
       0.13   13.3   0.7        1.6    9.7   0.0    3.2  3  NIDO        Nidogen-like
        6.9    6.5   9.9         26    4.6   0.6    3.2  2  PsbH        Photosystem II 10 kDa phosphoprotein


Domain annotation for each model (and alignments):
>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.8   0.2   1.7e-18   4.4e-15       2     103 ..    1403    1513 ..    1402    1514 .. 0.87

  Alignments for each domain:
  == domain 1  score: 55.8 bits;  conditional E-value: 1.7e-18
       PAS_9    2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlf.....vtdpeanerlraaleqgrk.....kerevevvlirkngetfwvlltaspvkdd 88  
                  +g++i+ ++g+i+ +N + lr++G+++ ++lg+s++dlf     + ++++   l ++ ++ r+     +++  ++++ rkn+++f++++t+++v+ +
  EFC37956.1 1403 EGTMICSENGEIELFNSSGLRMFGSKSIDILGTSMFDLFdipcrDVAKRTVAHLVNQCKEQRSdeenaNVEILDIEFLRKNQTKFPAKVTIYAVQFA 1499
                  7999*99*********************************9888666666666666666666699999**************************777 PP

       PAS_9   89 dgelvgiivilrDit 103 
                  ++  + i+v+++D+t
  EFC37956.1 1500 GK-TTNILVTFKDVT 1513
                  43.34467******9 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.0   8.4e-09   2.2e-05       3     113 .]    1394    1512 ..    1392    1512 .. 0.94

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 8.4e-09
                  HHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHH....HHHHHHHHHHHHTT-ECCCCEEEEC.....TTSSEEEEE CS
         PAS    3 lraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheedda....elaelleqlleqgeesrageisfkl.....rdgrpihle 90  
                  l+ +++s+ +++++  e+g+i ++N++  +++G +  ++lg s++dl+  + ++    ++a l+ q+ eq++++++ ++ +       ++++++++ 
  EFC37956.1 1394 LKVVFNSSVEGTMICSENGEIELFNSSGLRMFGSKSIDILGTSMFDLFDIPCRDvakrTVAHLVNQCKEQRSDEENANVEILDieflrKNQTKFPAK 1490
                  567889999*****************************************99999************************9999************** PP

                  EEEEEEEETTEEEEEEEEEEEES CS
         PAS   91 vraspvrdaggeilgflgvlrdi 113 
                  v+   v +ag++ + +l++++d+
  EFC37956.1 1491 VTIYAVQFAGKT-TNILVTFKDV 1512
                  *********775.6******997 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.2       3.2   8.2e+03     165     193 ..     424     452 ..     419     460 .. 0.57
   2 !   17.3   0.1   9.8e-07    0.0025     192     221 .]    1516    1545 ..    1502    1545 .. 0.91

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3.2
       HNOBA 165 elvlagiqqsaelelaldqleeksaeLee 193
                 ++++++ q +++++  +d+l++  + +e+
  EFC37956.1 424 NFIIQNSQTESKTQTDEDNLKQLYSCIER 452
                 45555666666666666655555554444 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 9.8e-07
       HNOBA  192 eesmkeleeekkrtdeLLysmiPkevAerL 221 
                  ++s+  l +ekk++d+LL +++P++vA+rL
  EFC37956.1 1516 KKSNMLLSDEKKKSDNLLKNILPNQVANRL 1545
                  4677789*********************98 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0     5e-05      0.13       1      60 [.    1398    1457 ..    1398    1516 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5e-05
       PAS_4    1 ldslpdalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvl 60  
                  ++s+ +++ +++++g ++  N ++ ++fg    ++lG ++++l+  ++++   r +++++
  EFC37956.1 1398 FNSSVEGTMICSENGEIELFNSSGLRMFGSKSIDILGTSMFDLFDIPCRDVAKRTVAHLV 1457
                  78999*************************************998885554444444444 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0     7e-05      0.18       3      52 ..    1394    1441 ..    1392    1455 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 7e-05
       PAS_8    3 lralfesspdgiavvd.lgdrivdvNqaalellGysadlkgellg..qllpvl 52  
                  l+ +f+ss +g +++  +g+ i   N + l+++G    +k  ++     ++ +
  EFC37956.1 1394 LKVVFNSSVEGTMICSeNGE-IELFNSSGLRMFG----SKSIDILgtSMFDLF 1441
                  6779*********9986888.*************....444222222333333 PP

>> NIDO  Nidogen-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1       1.5   3.9e+03      68      83 ..     128     143 ..     124     144 .. 0.88
   2 ?   -3.6   0.0         7   1.8e+04      50      79 ..     828     858 ..     809     859 .. 0.74
   3 ?    9.7   0.0   0.00064       1.6      13      79 ..    1342    1406 ..    1334    1409 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.5
        NIDO  68 tessnvgvpGrwafrv 83 
                  +++n g++G ++f+v
  EFC37956.1 128 VRNFNWGEEGKYVFKV 143
                 57899*********98 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 7
        NIDO  50 kkkyyn.lpgsgtssilnltessnvgvpGrw 79 
                 k+ y+n  ++  ++si+ l++   vg+ G++
  EFC37956.1 828 KTVYINdHKNRMNNSIIALKKLIAVGQLGVF 858
                 3556665667778899999999999999986 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00064
        NIDO   13 sesfal.fnYedggiqwttgkegetpaqaGfsagdgstkkkyynlpgsgtssilnltessnvgvpGrw 79  
                   +sf l +nY    i +  ++ ++ +a a +++ dg+t+++  + ++s++++ +nl+  +n+ v+G  
  EFC37956.1 1342 VHSFRLmLNYVP--IDVLDHN-EKLRAFALYNKMDGKTETRAKRNTNSEEDEYYNLKVVFNSSVEGTM 1406
                  578988789999..9999654.579**********99*9**9999********************976 PP

>> PsbH  Photosystem II 10 kDa phosphoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.6      0.01        26      19      42 ..     155     178 ..     153     185 .. 0.77
   2 ?    4.3   3.0     0.013        32      24      43 ..     994    1013 ..     993    1016 .. 0.94

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.01
        PsbH  19 aPGWGttpvmavfilLflvfLvii 42 
                 +P  Gt+ + avf++++l+  v +
  EFC37956.1 155 VPYFGTVGIAAVFMFIVLLTAVLL 178
                 8999********998766554444 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.013
        PsbH   24 ttpvmavfilLflvfLviil 43  
                  t+ ++++f++  +vfL i+l
  EFC37956.1  994 TVSILGIFMAVSFVFLTILL 1013
                  889***************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1566 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1504  (0.0838864); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.02u 0.34s 00:00:01.36 Elapsed: 00:00:00.51
# Mc/sec: 9176.71
//
Query:       EFC37957.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.1e-45  153.1   0.2    7.3e-45  152.8   0.2    1.1  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  152.8   0.2   4.1e-49   7.3e-45      34     182 ..       1     151 [.       1     152 [. 0.97

  Alignments for each domain:
  == domain 1  score: 152.8 bits;  conditional E-value: 4.1e-49
  Guanylate_cyc  34 lLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaves...keglkvrvGihtGpvvagviGakkprydvw 126
                    +Ln++++ fd l+++++++k+ktiGday  v gl++++ +h ++++++a+d +  +++ ++++    e++++rvGi+tG vvagviG kk+ yd+w
     EFC37957.1   1 MLNSIVNGFDVLTEKYELEKIKTIGDAYFLVGGLHNSQSDHPERVLKFAIDAFGVIHQYNKNKvveTEDINIRVGINTGAVVAGVIGSKKFAYDLW 96 
                    79******************************************************88888887878***************************** PP

  Guanylate_cyc 127 GntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182
                    G+++n+Asrmestg++g iq+s++tye   + ++e++er e+evkGkg ++ty+++
     EFC37957.1  97 GDAINVASRMESTGVPGTIQISRSTYERVFDLGYEFEER-EIEVKGKGSVKTYLMK 151
                    ******************************9*****998.79***********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       553  (0.0308439); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1292.64
//
Query:       EFC37958.1  [L=218]
Description: glutathione S-transferase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.8e-21   74.8   0.3    7.3e-21   74.2   0.3    1.3  1  GST_C_3   Glutathione S-transferase, C-terminal domain
    5.4e-11   42.6   0.1    8.7e-11   41.9   0.1    1.4  1  GST_C     Glutathione S-transferase, C-terminal domain
    4.2e-08   33.4   0.1    2.1e-07   31.2   0.0    2.1  2  GST_N     Glutathione S-transferase, N-terminal domain
    7.5e-06   26.3   0.0    1.6e-05   25.2   0.0    1.5  1  GST_N_3   Glutathione S-transferase, N-terminal domain
    9.6e-05   22.6   0.0    0.00019   21.7   0.0    1.5  1  GST_N_2   Glutathione S-transferase, N-terminal domain
    0.00016   21.6   0.0    0.00042   20.3   0.0    1.7  1  GST_C_2   Glutathione S-transferase, C-terminal domain
      0.007   16.7   0.2      0.017   15.4   0.0    1.7  2  Tom37     Outer mitochondrial membrane transport complex prot
  ------ inclusion threshold ------
      0.011   16.4   0.0      0.029   15.1   0.0    1.6  1  GST_N_4   Glutathione S-transferase N-terminal domain


Domain annotation for each model (and alignments):
>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.2   0.3   3.3e-24   7.3e-21      15      97 ..     118     204 ..     103     206 .. 0.84

  Alignments for each domain:
  == domain 1  score: 74.2 bits;  conditional E-value: 3.3e-24
                 CHHH..HHHHHHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHH...TCC.CC-HHHHHHHHHHHTSHHHHHHHC CS
     GST_C_3  15 keea..ekkkefleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleea...eal.kkfpklkalyervearpkikaYle 97 
                 +e +  + k e++e r   fl++fe+vl+++++g+lvg++l++AD++l+++l   +++   +   +k+p+l +l++++e++p++k+Y++
  EFC37958.1 118 AE-TaeKDKTEWKEGRQAFFLSKFEQVLAHSKSGFLVGNTLSWADICLYDALYEQKFLfasD-FaEKYPHLSKLMNQMEELPNLKSYIN 204
                 22.146999********************99999************************9643.26**********************96 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.9   0.1   3.9e-14   8.7e-11      20      93 .]     124     197 ..      89     197 .. 0.82

  Alignments for each domain:
  == domain 1  score: 41.9 bits;  conditional E-value: 3.9e-14
                 HHHHHHHHHHHHHHHHHHHHHHHH..TSSSSSTTSSCHHHHHHHHHHH.HHHHHTTTTTTTTSHHHHHHHHHHHTSH CS
       GST_C  20 keelvdealekvaevlsaleeelk..kqdylvGdkltlADialvpiln.wlqrlglafgqekfpnlkawlerimarp 93 
                 ++   + ++ + a  ls +e +l+  k+++lvG+ l++ADi+l+++l  + + +  +f  ek+p+l++ ++ + ++p
  EFC37958.1 124 DK--TEWKEGRQAFFLSKFEQVLAhsKSGFLVGNTLSWADICLYDALYeQKFLFASDFA-EKYPHLSKLMNQMEELP 197
                 33..34444555566899999999999*******************9878888888888.*************9987 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2   0.0   9.5e-11   2.1e-07       1      76 []       1      71 [.       1      71 [. 0.88
   2 ?   -1.0   0.1         1   2.4e+03      28      51 ..     169     192 ..     164     200 .. 0.74

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 9.5e-11
                EEEEEESSSTSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTTS-SSEEEET.TEEEESHHHHHHHHHH CS
       GST_N  1 avltlysirgsprahrirlllaakgveyevvpldfeageekspellklnplgkvPaLedn.gkkltESraIleYiar 76
                ++l++++i    r++++ l +    +++e + + + +   ++++l+k+ p+g++P+Le++   +l++S aI++++a+
  EFC37958.1  1 MQLHYFNIQA--RSEAAYLIALQGQLPVERKGVSS-F---ADSDLKKSAPFGQLPLLETDdSTVLAQSLAICQFLAE 71
                7899999999..88888888778899999999996.3...369****************9999***********985 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1
                 EEEEEECSTTTCGGCHHHHHHCTT CS
       GST_N  28 yevvpldfeageekspellklnpl 51 
                 ye+++l  ++++ek p l kl + 
  EFC37958.1 169 YEQKFLFASDFAEKYPHLSKLMNQ 192
                 888999888999988888877654 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.2   0.0   7.1e-09   1.6e-05      21      72 ..      23      74 ..       5      82 .. 0.80

  Alignments for each domain:
  == domain 1  score: 25.2 bits;  conditional E-value: 7.1e-09
                T--EEEE---TTTTHHHHHHH-TT--SSEEE.TTS-EEESHHHHHHHHHHHH- CS
     GST_N_3 21 glpvevvevtpgehdeellaknplgkvPvLe.ddgealtdSlaIidyLeelyp 72
                +lpve   v+ +     l++  p g++P Le dd ++l  SlaI+++L e+ +
  EFC37958.1 23 QLPVERKGVSSFAD-SDLKKSAPFGQLPLLEtDDSTVLAQSLAICQFLAEKSN 74
                56666666666664.4577888********846699************99865 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.0   8.4e-08   0.00019      35      69 ..      37      71 ..      15      72 .. 0.88

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 8.4e-08
                HHHHHHCTTTSSSEEE-CTTEEEESHHHHHHHHHH CS
     GST_N_2 35 eefprlnprgtVPvLwdkdgqvineSseIlrylet 69
                +++++  p+g++P+L ++d++v++ S++I+++l++
  EFC37958.1 37 SDLKKSAPFGQLPLLETDDSTVLAQSLAICQFLAE 71
                4889999**************************87 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.0   1.9e-07   0.00042      15      66 ..     137     202 ..     127     204 .. 0.68

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 1.9e-07
                 HHHCTTT---SS...CTTCS--HHHHHHHH......HHHHHHHH..HHS-....---TT-HHHHHH CS
     GST_C_2  15 ldaleahLadsp..flfGdqptlaDialap......flvrlraa..gpgf....direaypnlraW 66 
                 l+++e+ La+s   fl G+++++aDi+l+       fl+  ++a  +p++    + +e++pnl+ +
  EFC37958.1 137 LSKFEQVLAHSKsgFLVGNTLSWADICLYDalyeqkFLFASDFAekYPHLsklmNQMEELPNLKSY 202
                 78899999999999***************7222333444444444333225555555666666655 PP

>> Tom37  Outer mitochondrial membrane transport complex protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   7.6e-06     0.017      25      77 ..      41      90 ..      14     100 .. 0.70
   2 ?   -2.0   0.0       1.9   4.2e+03      69      96 ..     177     204 ..     132     207 .. 0.60

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 7.6e-06
       Tom37 25 slsptgeLPaLkdgegtwisgfdnIveylrkks...eesdldaslsakekadatAl 77
                +  p g+LP+L ++++t +++   I+++l +ks         ++ sa  + + +Al
  EFC37958.1 41 KSAPFGQLPLLETDDSTVLAQSLAICQFLAEKSnllP-----SQSSAN-QGQDSAL 90
                55899********997777***********9853331.....233333.3333333 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.9
       Tom37  69 kekadatAlisllesklaplllyslyvn 96 
                 ++ a+++ ++s l ++++ l ++  y+n
  EFC37958.1 177 SDFAEKYPHLSKLMNQMEELPNLKSYIN 204
                 4444444455555555555555555555 PP

>> GST_N_4  Glutathione S-transferase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.0   1.3e-05     0.029      27      80 ..      41      94 ..      31      98 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.3e-05
     GST_N_4 27 haspkgklPfielngelliadsefiieflkekgvdld.aelseeqkadaralkal 80
                +++p g+lP +e +++ ++a s  i +fl ek  +l  ++ s+ q +d+  l al
  EFC37958.1 41 KSAPFGQLPLLETDDSTVLAQSLAICQFLAEKS-NLLpSQSSANQGQDSALLNAL 94
                568**********6666***************9.766577777776666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       331  (0.0184617); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1488.20
//
Query:       EFC37959.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.052   12.8   0.1      0.074   12.3   0.1    1.2  1  Pox_A11   Poxvirus A11 Protein
      0.075   13.1   1.2       0.38   10.9   0.9    2.3  1  Erf4      Golgin subfamily A member 7/ERF4 family


Domain annotation for each model (and alignments):
>> Pox_A11  Poxvirus A11 Protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   8.3e-06     0.074     187     246 ..      43     105 ..       7     119 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 8.3e-06
     Pox_A11 187 ssevnkrvaivnyaslnksdlsledlevcseee...idkiykvvkqynesrkkkilvtnfiii 246
                 ss+    +++  ya+ n s++sl ++ ++++e    +d++y+ vk y+  +    +++ ++ i
  EFC37959.1  43 SSDGCSNLILSQYAAPNSSPISLGEITQITNEVntiVDQVYNSVKMYDYIYWTTFIISMVLAI 105
                 555556788999**************99998744449*************9999999988876 PP

>> Erf4  Golgin subfamily A member 7/ERF4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.9   4.3e-05      0.38      32     104 ..      73     160 ..      50     171 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 4.3e-05
        Erf4  32 eefeeiinkiNeilaeafspysvrnildnvlglltlylwslvlk..........thykkklkk........lekyieelNeelfkerglki 104
                 +e ++i++++ + ++    +y++  i+ +vl++ t++l+   +           +   k + k        +++++e+ N+e f++ gl++
  EFC37959.1  73 NEVNTIVDQVYNSVKMYDYIYWTTFIISMVLAIPTMGLSVFGIIfvmflpmmkaQ---KIITKlnnvakpqIQQVLERKNQERFEPAGLQW 160
                 4455555555555555555666677778888888888554444422333342231...222224445555577777777777777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1061  (0.0591779); expected 358.6 (0.02)
Passed bias filter:                      531  (0.0296168); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1307.51
//
Query:       EFC37960.1  [L=553]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.5e-60  203.5   0.1    3.7e-60  202.9   0.1    1.3  1  FAD_binding_7   FAD binding domain of DNA photolyase
    1.6e-28   99.8   0.0    2.4e-28   99.2   0.0    1.3  1  DNA_photolyase  DNA photolyase


Domain annotation for each model (and alignments):
>> FAD_binding_7  FAD binding domain of DNA photolyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  202.9   0.1   4.1e-64   3.7e-60       3     198 ..     316     532 ..     313     536 .. 0.95

  Alignments for each domain:
  == domain 1  score: 202.9 bits;  conditional E-value: 4.1e-64
                    HHHHHHHHHHHHHHCSTTT.....................TTSSTTGCCTT------HH.HHHHHHTT-SS-HHHHHHHHHHHHHS---HHHHHHH CS
  FAD_binding_7   3 reLlwrefyyallaaepel.....................aeralkekfdripweeseeekleaWkeGrTGfPlvDAamrqLretGwmhnrlRmiv 77 
                     eLlwr++++  ++++ +                      +++++++k+d+++w+++ +  ++ W++G+TG+P+vDA mr+L+ +Gwm+nr+R+ v
     EFC37960.1 316 FELLWRDYFRFFAEKFGNHifmlkgvtrasskrkgligdsSSNKVESKYDETRWKQDLK-LFKLWADGKTGLPFVDANMRELKISGWMSNRGRQNV 410
                    69**************66669****************9987999**********88766.7*********************************** PP

                    HHHHCTTT-B-HHHHHHHHHHH-TT--CCHHHHHHHHHCT-ST.TS-STT----CCCCHHHCSTT-HHHHHH-GGGTTS-HHHHT-GGGSGCHHHH CS
  FAD_binding_7  78 asFltkdLlidWregeevFeellvDadlasnagnwqwlagtga.daapafrifnpvkqgkkfDpegeyirrwvpeLkklpakyihepwkapaeeqk 172
                    asFl+kdL +dWr g+e+Fe+ll+D+ + sn+gnw ++ag+g  d +   r+fn+vkqg ++D +ge+++ w+peL+++p+++ih+p+ ++++eq+
     EFC37960.1 411 ASFLSKDLNLDWRLGAEYFESLLLDHSVTSNWGNWLYAAGVGDvDPRGEARYFNVVKQGFDYDFNGEFVKLWIPELDQVPQRCIHAPYLMSESEQT 506
                    ****************************************8744999999********************************************** PP

                    HHT--TTTSS---SS-HHHHHHHHHH CS
  FAD_binding_7 173 kagvvlgkdYpkpivdhkearkrale 198
                    +a++++g dYpk +v++k++++ + +
     EFC37960.1 507 NAKCTIGVDYPKSLVNVKAHHHLNEN 532
                    ******************99887766 PP

>> DNA_photolyase  DNA photolyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.2   0.0   2.7e-32   2.4e-28       1     154 [.      11     175 ..      11     189 .. 0.85

  Alignments for each domain:
  == domain 1  score: 99.2 bits;  conditional E-value: 2.7e-32
                     EEEEESS---STT-HHHHHH....HCTTSE.........EEEEEEE-HH.....HHTCG....S-CHHHHHHHHHHHHHHHHHH.HHTT--EEEE CS
  DNA_photolyase   1 vlvWfrrDlRlhDNpALaaA....aasgep.........vipvfvldpe.....kahkl....rvgaarvdfllesLadLdeeL.relgirLvvr 72 
                     +l+Wfr+DlRlhDN+ L +     +    +         v+p++++dp+     +   +    +++a+r +fl es+ +L+++L +e g +L++ 
      EFC37960.1  11 ALLWFRNDLRLHDNESLIKTlrlaN----SsnnntskvgVLPLYCFDPRhfgfsR---IgkfrKANANRTRFLTESVDNLRKNLmNEWGLKLMIQ 98 
                     589***************6644321....2223466777**********764431...3666777*******************8999******* PP

                     ESSHHHHHHHHHHHCTECEEEEE---SHHHHHHHHHHHHHHHHCTSEEEEE--SSSS-HHHHHTTTSSSHSSHHHHHHCHHH CS
  DNA_photolyase  73 rgdpadvlpelakelgasavvanreyepdererdeavkealrkagievesfddhtlvepgevktkkgkpykvFtpfrkrwlk 154
                      g p++++p l++++++++v+a++e++++e++ ++ +++     +i+v+   +  +v+++++++k + +++vFt fr+++++
      EFC37960.1  99 IGHPEEIIPHLCSQYEIEQVFADKEVTSEETSIEQVLEK-----QINVNYSYGFSMVHVEDLPFKIENLPHVFTDFRRKVEN 175
                     ******************************998766555.....5889*******************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (553 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       439  (0.0244855); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.26s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 3396.90
//
Query:       EFC37961.1  [L=631]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   1.6e-207  690.4   3.6     2e-207  690.1   3.6    1.0  1  HSP70        Hsp70 protein
    7.7e-17   61.1   0.7    6.7e-15   54.7   0.1    2.9  2  MreB_Mbl     MreB/Mbl protein
    1.1e-05   25.7   0.5       0.18   12.2   0.0    3.6  3  FtsA         Cell division protein FtsA
     0.0011   18.7   0.2     0.0034   17.1   0.0    1.8  2  FGGY_C       FGGY family of carbohydrate kinases, C-terminal 
  ------ inclusion threshold ------
      0.037   13.5   0.0        7.7    5.9   0.0    3.0  3  BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
       0.18   12.2   0.7       0.95    9.8   0.0    2.5  3  RuvX         Holliday junction resolvase
       0.25   11.0   1.8        1.4    8.6   0.0    2.8  3  Raco_middle  RACo middle region


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  690.1   3.6  7.9e-211    2e-207       1     588 [.      28     628 ..      28     630 .. 0.96

  Alignments for each domain:
  == domain 1  score: 690.1 bits;  conditional E-value: 7.9e-211
                 EEEEEEXSSEEEEEEEETTE.....EEEEXXTTSXSSEESEEEEXTTSEE.ETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHHHTTXSSEEEEET CS
       HSP70   1 viGiDLGttnsvvavmeggk.....ievianeegnrttPsvvaFtkkerl.vGeaAkrqavtnpkntvfsvKrliGrkfsdpevqkeikelpykvvkke 93 
                 v+GiDLGttns+va+meg++     ++v++ne g rttPsvvaF+++++l vGe+Akrqa++npknt+ +vKrliG +++d  + k+ ++lp+++v+ +
  EFC37961.1  28 VLGIDLGTTNSCVAIMEGNHldavhVRVLENELGFRTTPSVVAFDSQDKLiVGEPAKRQAIMNPKNTLHAVKRLIGLSYED--ARKNGHSLPFELVSGK 124
                 79***************98533333789*******************66438****************************9..9999************ PP

                 TSBEEEEEEETTEEEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSS........S CS
       HSP70  94 ngkavveveaagekftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkd........k 184
                  g++ +++  +g++f+p+qisa++L+++++ a++ylg++++ avitvPaYfn++q+qat+dAg iAG+ v Ri+NepTAaalaYGl  k         +
  EFC37961.1 125 RGQVAIRMG-NGKEFSPTQISAFILQHMRDVAQQYLGQRIDRAVITVPAYFNENQKQATMDAGMIAGITVERIINEPTAAALAYGLGGKRfsnfeindR 222
                 *******99.99**************************************************************************9999999999999 PP

                 CEEEEEEEEXSSXEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEE CS
       HSP70 185 ernvlvyDlGggtfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrlkeaaekaKkeLSsskqteinleietvd 283
                 + +++v+DlGggtfdvSile++  vf+v+aT+gD  lGGedfD+++++++v++fk++++++l++d+ a+qrlkeaaekaK+eLSs+ +teinl+++  +
  EFC37961.1 223 DGTIVVFDLGGGTFDVSILEISGDVFQVVATNGDAFLGGEDFDNRILQWIVKKFKEEQKVNLEEDPLAYQRLKEAAEKAKIELSSVISTEINLPFIGRN 321
                 99************************************************************************************************* PP

                 TTT.EEEEEEEEHHHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTTCHHBSSSHTTTHHHHHHHHHHHHHCTC..G CS
       HSP70 284 edg.kdlseklsRakfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfgkepsktvnpDeavaiGAAvqagvlsge..e 379
                 + g ++l+++l+R++fe++++dl+ertl+pv+k++kda+l+ ++i++v+lvGG+tR+P ++++v+++f++ p+k+vnpDeavaiGAA+q+ + sg+  e
  EFC37961.1 322 AFGpVNLKMTLKRSEFETMCADLVERTLKPVQKCMKDAGLRPSDISQVILVGGMTRMPLIEKMVSSYFQQTPNKSVNPDEAVAIGAAIQGSICSGQlvE 420
                 ***********************************************************************************************9877 PP

                 CSHCCEEEEBESS-EEEEETTTEEEEEESTTCBSSEEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSC CS
       HSP70 380 evkdllllDvtpLslgietlggvmtkliernttiptkksqvfstaadnqtaveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfdidanGi 478
                   + ++llDv+pLslg+ +  +v + +i+rnt +p++ ++ f+t++dnqt++ i ++qgerel+++nk+lg+  l+gippap+G p+i+ tf+id+nG+
  EFC37961.1 421 TKQSIILLDVVPLSLGVALVNDVYKVMIPRNTQVPARFADHFTTIKDNQTNILIDIYQGERELASKNKNLGQMVLSGIPPAPKGIPNIKTTFSIDVNGL 519
                 8899*********************************************************************************************** PP

                 EEEEEEETTTCCEEEEEEECCSSSBHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHGGGSTHHHHHHHHHHHHHHHCHTTSSCHH CS
       HSP70 479 ltvsakdketgkeeeitieaseglseeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleeeaekvseaekekvesaieeLkeeleeeeke 577
                 l v+++d+++g + ++ i+++++l+++eie+m k ae+++ +d ++ e   +k e+eel+++ e++ + +++  s+++++++ +ai+eL++++++++++
  EFC37961.1 520 LFVESEDMASGSQVNMFITSHNSLTNQEIEEMRKLAEQYKYQDTQQVEWNVKKTESEELIQKCENSQHVAKD-SSNEKQAELGEAIRELRHSVSNRDSA 617
                 ****************************************************************99877755.56688899****************99 PP

                 HHHHHHHHHHH CS
       HSP70 578 eieakteelkk 588
                 ++ + t+ lk+
  EFC37961.1 618 KYTSITDLLKR 628
                 99988887765 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1     0.011        29       4      47 ..      29      84 ..      27     102 .. 0.53
   2 !   54.7   0.1   2.6e-18   6.7e-15      77     317 ..     147     409 ..     131     415 .. 0.79

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.011
                EEEEE-SSEEEE.EETTTEE......EEEE.......ES-EEEETTT--EEEESHHHH CS
    MreB_Mbl  4 lgiDLGtantlv.yvkgkgi......vlne.......psvvAikkktkkvlavGeeAk 47
                lgiDLGt+n  v  ++g+ +      vl++       psvvA+++++k    vGe Ak
  EFC37961.1 29 LGIDLGTTNSCVaIMEGNHLdavhvrVLENelgfrttPSVVAFDSQDKL--IVGEPAK 84
                7999999999883333432211111233211222222777777666553..3566665 PP

  == domain 2  score: 54.7 bits;  conditional E-value: 2.6e-18
                 HHHHHHHHHHT.SS-SS--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT-........-TTSSS-EEEE.EE-SS-EEEEEEETT CS
    MreB_Mbl  77 llkyfikkvkk.kkslskprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGagl........pveepsgnmvv.diGggttevavislg 165
                 +l+  +++v++     + +r vi+vP   +e +++A ++a + aG +   +i+ep aAA+  gl        ++++  g++vv d+Gggt +v+++ ++
  EFC37961.1 147 ILQ-HMRDVAQqYLGQRIDRAVITVPAYFNENQKQATMDAGMIAGITVERIINEPTAAALAYGLggkrfsnfEINDRDGTIVVfDLGGGTFDVSILEIS 244
                 344.4444444144557899***************************************96544333333339*******9866************988 PP

                 E....EE.EEEEES-SHHHHHHHHHHHHHHHHS....EE--H.........HHHHHHHHHH-BSS--HHHHEEEEEEEETTTTCEEEEEEEHHHHHHHH CS
    MreB_Mbl 166 g....iv.tsksvrvaGdeldeaiikyirkkyn....lliGe.........rtaekikieigsavkeeeeekmeikGrdlvtglpkevevsseevreal 246
                 g    +v t     ++G+++d+ i+++i kk++    + + e         + aek kie++s++++e   ++   Gr+    +  +++++ +e + + 
  EFC37961.1 245 GdvfqVVaTNGDAFLGGEDFDNRILQWIVKKFKeeqkVNLEEdplayqrlkEAAEKAKIELSSVISTEI--NLPFIGRNAFGPVNLKMTLKRSEFETMC 341
                 7222222123345689************88885332255543222222222579999999999998765..56789*********************** PP

                 HHHHHHHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS-EEE-SSTTTHHHHHHHH CS
    MreB_Mbl 247 kepvsaiveavkevLektppeLaadivdrgivltGGgallkgldkllseetglpvkvaedpltcvakGtgk 317
                 ++ v++ ++ v++ ++++     +di +  ++l+GG + +  ++k++s+ ++   + + +p ++va G+++
  EFC37961.1 342 ADLVERTLKPVQKCMKDAGLR-PSDISQ--VILVGGMTRMPLIEKMVSSYFQQTPNKSVNPDEAVAIGAAI 409
                 ***************986533.578875..8999**********************************975 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.1   0.00063       1.6       2      23 ..      30      53 ..      29     171 .. 0.92
   2 !   12.2   0.0     7e-05      0.18       1     103 []     227     406 ..     227     406 .. 0.65
   3 ?   -1.0   0.1      0.94   2.4e+03      39      62 ..     546     572 ..     507     629 .. 0.53

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00063
                EEEE-SSSEEEEEEETTEEEE..E CS
                xxxxxxxxxxxxxxxxxxxxx..x RF
        FtsA  2 lvDiGagktdvavaedgalvh..l 23
                ++D+G++ ++va++e+++l +  +
  EFC37961.1 30 GIDLGTTNSCVAIMEGNHLDAvhV 53
                79**************98766224 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 7e-05
                 EEEEE-SSSEEEEEEETTEEEEEEEES-......-HHHHHHH.....................HHHHHT--HHHHHHHHHHH--S--.........EEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxx.....................xxxxxxxxxxxxxxxxxxxxxxxx.........xxx RF
        FtsA   1 alvDiGagktdvavaedgalvhlrvigv......ggngitkd.....................iakalrtaveeAerikikyGsala.........eke 63 
                 ++ D+G+g+ dv+++e ++ v ++v+ +      gg+ +++                      +  a++   e+Ae+ ki+  s+++         +  
  EFC37961.1 227 VVFDLGGGTFDVSILEISGDV-FQVVATngdaflGGEDFDNRilqwivkkfkeeqkvnleedpL--AYQRLKEAAEKAKIELSSVISteinlpfigR-- 320
                 577**************6544.777777566667777777774444333333333333333221..1255555555555555555555555555551.. PP

                 EEHHHHH....................................................GGGGSTTHHHHHHHHHT-..HHHT-GGGHHHHH CS
                 xxxxxxx....................................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        FtsA  64 igrkels....................................................ggsalpnleelaeralspkleevsdpeyasalg 103
                       +                                                    g + +p +e+++++ +++  ++  +p  a+a+g
  EFC37961.1 321 ------NafgpvnlkmtlkrsefetmcadlvertlkpvqkcmkdaglrpsdisqvilvgGMTRMPLIEKMVSSYFQQTPNKSVNPDEAVAIG 406
                 ......0555555556666666668888888888888888899999999999999999****************965444566777777776 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.94
                 HHHT--HHHHHHHHHHH--S--...EE CS
                 xxxxxxxxxxxxxxxxxxxxxx...xx RF
        FtsA  39 kalrtaveeAerikikyGsala...ek 62 
                 + + +  + Ae+ k ++  +++   +k
  EFC37961.1 546 QEIEEMRKLAEQYKYQDTQQVEwnvKK 572
                 444444555555553333333344322 PP

>> FGGY_C  FGGY family of carbohydrate kinases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       1.5   3.8e+03      50      84 ..     268     299 ..     266     310 .. 0.55
   2 !   17.1   0.0   1.3e-06    0.0034     140     195 ..     354     412 ..     332     414 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.5
      FGGY_C  50 lvawlldnlglreeirdageveeslaelaaaeava 84 
                 +++w++++ +  ++++ +++   +la ++  ea++
  EFC37961.1 268 ILQWIVKKFKEEQKVNLEED---PLAYQRLKEAAE 299
                 78999999555444444444...343333333333 PP

  == domain 2  score: 17.1 bits;  conditional E-value: 1.3e-06
      FGGY_C 140 ealekd..sgkpldrlavdGGgskndllmqllAdilg.vpVerpktaeatalGaAilAa 195
                 +++++   +++++++++++GG+++ +l+ ++  + ++ +p + + ++ea+a+GaAi + 
  EFC37961.1 354 KCMKDAglRPSDISQVILVGGMTRMPLIEKMVSSYFQqTPNKSVNPDEAVAIGAAIQGS 412
                 445444666788*************************999999999**********875 PP

>> BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.018        46       1      19 [.      29      47 ..      29     198 .. 0.84
   2 ?    0.6   0.0      0.13   3.2e+02       4      77 ..     230     323 ..     227     351 .. 0.72
   3 ?    5.9   0.0     0.003       7.7     213     265 ..     359     409 ..     322     411 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.018
                 EEEEE-SSEEEEEEEETTT CS
  BcrAD_BadFG  1 vGiDgGsTttkavlmdekg 19
                 +GiD+G+T   +++m+ + 
   EFC37961.1 29 LGIDLGTTNSCVAIMEGNH 47
                 7*******99999998654 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.13
                  EE-SSEEEEEEEETTTEEEEEEEE--.....................TTS-HHH..........HHHHHHHHHHT--GGGECEE..EEESTTCCCT CS
  BcrAD_BadFG   4 DgGsTttkavlmdekgevlgrgitns.....................anlesvrfeaaekvle.ealtealerageeeadieetylvgtgyGratl 77 
                  D+G++t  + +++ +g+v     tn+                     +  e+ +++  e++l  + l+ea e+a+ e +++ +t + + ++Gr+  
   EFC37961.1 230 DLGGGTFDVSILEISGDVFQVVATNGdaflggedfdnrilqwivkkfK--EEQKVNLEEDPLAyQRLKEAAEKAKIELSSVISTEINLPFIGRNAF 323
                  899999999999999999999999998888888888888888885331..2233333444443277888888888888888888888888888754 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.003
                  T---SS....EEEESGGGG-HHHHHHH.....HHHH-S-EE--GGGGGHHHHHHHH CS
  BcrAD_BadFG 213 sggvtde...vtltGGvakneaavkelrklvkenygevkininpdsiytgalGAal 265
                   g ++ +   v+l+GG+ +  ++    +k+v++ +++ + n ++ ++ + a+GAa+
   EFC37961.1 359 AGLRPSDisqVILVGGMTRM-PLI---EKMVSSYFQQ-TPNKSVNPDEAVAIGAAI 409
                  4444333455*********9.555...4456666655.78**************96 PP

>> RuvX  Holliday junction resolvase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00037      0.95       3      66 ..      28      88 ..      26     109 .. 0.86
   2 ?   -1.2   0.0      0.97   2.5e+03      38      73 ..     149     184 ..     136     197 .. 0.78
   3 ?   -2.9   0.1       3.2   8.2e+03      36      52 ..     542     560 ..     527     578 .. 0.63

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00037
                EEEEEESSSEEEEEEE-S--SS---EEEEE---HHHHHHHHHHHHHHTT--EEEEE------SS CS
        RuvX  3 ilglDvGtkriGvAvsdplgilaspletierkskekdleelkelvkeeeveeiVvGlPlnldgs 66
                +lg+D+Gt +  vA+ + +   a  ++++e++     +++  ++v+  + ++++vG P + +  
  EFC37961.1 28 VLGIDLGTTNSCVAIMEGNHLDAVHVRVLENE---LGFRTTPSVVAFDSQDKLIVGEPAKRQAI 88
                79***************************999...789999999999999********877654 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.97
                 HHHHHHHHHHHHTT--EEEEE------SSS---SST CS
        RuvX  38 kdleelkelvkeeeveeiVvGlPlnldgsegesakk 73 
                 ++++++++    +++++ V+ +P   ++++++++  
  EFC37961.1 149 QHMRDVAQQYLGQRIDRAVITVPAYFNENQKQATMD 184
                 456667777777799999999999998888777665 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 3.2
                 H..HHHHHHHHHHHHHTT- CS
        RuvX  36 k..ekdleelkelvkeeev 52 
                 +  ++++ee+++l+++++ 
  EFC37961.1 542 SltNQEIEEMRKLAEQYKY 560
                 2334566666666666654 PP

>> Raco_middle  RACo middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1       0.2   5.2e+02       4      25 ..      30      51 ..      28      59 .. 0.75
   2 ?    8.6   0.0   0.00056       1.4      52     116 ..     334     398 ..     326     420 .. 0.85
   3 ?   -2.7   0.1       1.6   4.2e+03      19      41 ..     582     604 ..     564     625 .. 0.62

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.2
  Raco_middle  4 avDiGtTtvvaaLvdletgkel 25
                  +D+GtT+ ++a+++ ++   +
   EFC37961.1 30 GIDLGTTNSCVAIMEGNHLDAV 51
                 69******99999886665555 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00056
  Raco_middle  52 eegleklqkavveeinelieelleeagiekeeiyevvvagNttMlhlllgldpkslakapyvpvv 116
                  +++ e++   +ve   + +++++++ag+++++i++v+++g  t + l+ ++  ++ +++p + v 
   EFC37961.1 334 RSEFETMCADLVERTLKPVQKCMKDAGLRPSDISQVILVGGMTRMPLIEKMVSSYFQQTPNKSVN 398
                  567788888899999999*************************9999999999999999987665 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.6
  Raco_middle  19 letgkelaeasalNpQikyGeDv 41 
                  +e+ + +a+ s+  +Q+++Ge +
   EFC37961.1 582 CENSQHVAKDSSNEKQAELGEAI 604
                  44555566666666666666544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (631 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1634  (0.0911373); expected 358.6 (0.02)
Passed bias filter:                      760  (0.0423894); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.81u 0.36s 00:00:01.17 Elapsed: 00:00:00.52
# Mc/sec: 3677.64
//
Query:       EFC37962.1  [L=622]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (622 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       666  (0.0371465); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.29s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3750.99
//
Query:       EFC37963.1  [L=413]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.1e-23   81.0   5.2    8.9e-06   26.2   0.1    4.4  4  Sel1      Sel1 repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.1   2.6e-09   4.6e-05       9      38 .]       1      28 [.       1      28 [. 0.92
   2 !   19.3   0.2   7.4e-08    0.0013       3      38 .]      31      64 ..      29      64 .. 0.93
   3 !   26.2   0.1   4.9e-10   8.9e-06       1      38 []      65     100 ..      65     100 .. 0.96
   4 !   11.1   0.0   2.9e-05      0.52       3      29 ..     103     127 ..     101     127 .. 0.92

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 2.6e-09
        Sel1  9 mfylylnGlgvpkDpekAiewyekAAeqGd 38
                m+y  +nGl v+kD  +A+ewy kA e+Gd
  EFC37963.1  1 MIY--ENGLTVEKDLAEALEWYLKAGENGD 28
                445..**********************997 PP

  == domain 2  score: 19.3 bits;  conditional E-value: 7.4e-08
        Sel1  3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38
                A+ +L+   ly +G gv++D+ k +ew  kAAe+Gd
  EFC37963.1 31 AQVNLA--RLYRDGEGVEQDYLKSFEWNMKAAEAGD 64
                99****..777**********************997 PP

  == domain 3  score: 26.2 bits;  conditional E-value: 4.9e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 aeA+   G  y+y++Glgv++D +k +ew  k Ae+G+
  EFC37963.1  65 AEAQVHIG--YAYDKGLGVEQDFSKSFEWNLKGAENGS 100
                 79******..*************************996 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 2.9e-05
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiew 29 
                  ++++G  +l++ G+gv+k+++k + w
  EFC37963.1 103 GQFNVG--LLLELGDGVEKNIKKSVFW 127
                 79****..777*************999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (413 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       932  (0.0519828); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 2745.26
//
Query:       EFC37964.1  [L=511]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (511 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1631  (0.0909699); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 3052.95
//
Query:       EFC37965.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-12   46.9   0.7    1.7e-10   41.1   0.7    2.7  1  BTB_2     BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.1   0.7   9.3e-15   1.7e-10       1      89 [.      63     187 ..      63     191 .. 0.77

  Alignments for each domain:
  == domain 1  score: 41.1 bits;  conditional E-value: 9.3e-15
                 EEEEETTEEEEEEHHHHHTS...TTSTTTSSGG.................................GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-.. CS
       BTB_2   1 vklnVgGtrfetskstLsrk...pdtlLgkllkte.............................elddydeetneyffDRspklFetiLnyyrtggk.. 65 
                 +kln++G+ f+++k+tL++k   p+    k+++ +                             +  ++d++tn++f++R+p++F+ iLny+r +g+  
  EFC37965.1  63 IKLNISGIVFKVFKETLDQKivkPKPTTIKFTNSRlrneqsmeqsteevqyyppnffnvlmsgiHNLSMDKDTNAIFINRDPTHFHCILNYLRGQGHsk 161
                 79***************97543333222222222345667777******************98768889999*********************875422 PP

                 ...B---TTS-HHHHHHHHHHHT--TT CS
       BTB_2  66 ...LhrpeevelkslleElefygleel 89 
                    L++ +   l+ l  E++fy le l
  EFC37965.1 162 dfvLPK-DSYALECLFIEARFYMLEGL 187
                 331444.4788888999*****99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1309  (0.0730102); expected 358.6 (0.02)
Passed bias filter:                      701  (0.0390987); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.24s 00:00:00.73 Elapsed: 00:00:00.42
# Mc/sec: 1469.31
//
Query:       EFC37966.1  [L=480]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-21   76.8  11.5    3.2e-21   76.0  11.5    1.4  1  Cation_efflux  Cation efflux family
    1.3e-09   38.1   0.0    2.7e-09   37.0   0.0    1.5  1  ZT_dimer       Dimerisation domain of Zinc Transporter


Domain annotation for each model (and alignments):
>> Cation_efflux  Cation efflux family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.0  11.5   3.6e-25   3.2e-21       2     198 ..     165     384 ..     164     385 .. 0.96

  Alignments for each domain:
  == domain 1  score: 76.0 bits;  conditional E-value: 3.6e-25
  Cation_efflux   2 ilsllanlilalvelivglltnSlalladafhslsdlvsllllllalklsrkppd.erfpfGygrlevlgalvsgllllglavfllleaiqkli.. 94 
                     ls++ n+ l++ +  + +l+ Sl+++   + s +dl+s l+++++  + r+++d +++p G+ rle++g ++ +  +  + ++++ e++ +++  
     EFC37966.1 165 HLSFWTNVCLFVLKCSASILSVSLSVITSTIDSALDLLSGLIIYITSLYRRRKNDiYQYPIGRNRLEPIGFVIFATCMCTASLQIIKEGLSQIVtg 260
                    6899******************************************9999777776**************************************** PP

  Cation_efflux  95 ............................kegereihaglalvvalvslvvnlalllilrragrklrsaalkaaalhvlgDaltslgvlvsalvill 162
                                                 + +++i  ++ ++v+l+ ++++lal li+rr+    +s+++ a a+++++D+l++   lvs++++++
     EFC37966.1 261 litgdvyinanssddsnaevdwmfgimiPKYVATIFYWYGIGVLLATILIKLALHLICRRVK---HSPSVIAYAFDHRNDVLSNSLLLVSLFLSKY 353
                    ****************************8899****************************96...8*****************************9 PP

  Cation_efflux 163 fnlksgplaDpvaslligliilysalkllkeslseL 198
                        +  ++D++++++++++i++s+ +   e +  L
     EFC37966.1 354 L---W--WLDSIGAVILSIYIIKSWIDESLEHVTKL 384
                    8...4..9*****************99998888776 PP

>> ZT_dimer  Dimerisation domain of Zinc Transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   0.0   3.1e-13   2.7e-09       4      77 ..     392     465 ..     389     466 .. 0.89

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 3.1e-13
                 .HHHHHHHHH.TT-SS-EEEEEEEEE-S----EEEEEEEE-TTS-HHHHHHHHHHHHHHHHHH-TT--EEEEEEE CS
    ZT_dimer   4 eeeeeireii.ksvpgvkgvhdlrtrksGskifvdlhievdgdlsvkeaHeiadevekrikeefpgvadvliHve 77 
                 e +++++ ++ ++ p +++v+++ + +sG +++v++++++++++++ e+H++ + ++k+i e++p+v+++++H++
  EFC37966.1 392 EYIQKLTFMAlNHSPLITQVDSVMAYYSGANMIVEIDVVLPKETPLLESHDVGETLQKKI-ESLPDVERCYVHLD 465
                 5566666666467999********************************************.599*********86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (480 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       845  (0.0471303); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 2621.85
//
Query:       EFC37967.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-09   36.9   1.3    1.1e-08   34.9   1.3    1.9  1  Fer2      2Fe-2S iron-sulfur cluster binding domain
  ------ inclusion threshold ------
      0.032   14.3   0.2       0.13   12.4   0.1    1.9  2  Fer2_4    2Fe-2S iron-sulfur cluster binding domain


Domain annotation for each model (and alignments):
>> Fer2  2Fe-2S iron-sulfur cluster binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   1.3   1.2e-12   1.1e-08       8      78 .]      13     101 ..       7     101 .. 0.71

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 1.2e-12
                 EEEEEETTTHBHHHHHHHTTTTTS......TTSSSSSS.SSTTEEEEEESCE.CTTSSSSTHHHHHTTEE................EEGGGSEES CS
        Fer2   8 vevevadgettlldaaeenggidi......pysCgggg.CgtClvevlegev.qsdetelegeeldegkl................rlaCqtivt 78 
                  ++eva g++ l  a+ en gi++       ++Cgg+g CgtC+v+vl+ +      + ++  ++ +g                  rlaCq+ vt
  EFC37967.1  13 KTFEVASGTN-LRAALVEN-GIPLyngkteTFNCGGNGtCGTCAVQVLDIDEkT---SVKDSMKRTSG-EemrlklpphfnknqdiRLACQCQVT 101
                 6899988888.99999988.7777333333478***889*********755431...23333333333.2467788999999999*******986 PP

>> Fer2_4  2Fe-2S iron-sulfur cluster binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   1.4e-05      0.13      12      59 ..      14      58 ..      13      81 .. 0.77
   2 ?   -0.8   0.0      0.18   1.6e+03      65      78 ..      94     107 ..      86     110 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.4e-05
      Fer2_4 12 evtvpeGdtvasAllangvdvprsckygrprgelcaggeCrnClVeve 59
                +++v  G+ + +Al +ng+ +     +       +  g C +C V+v 
  EFC37967.1 14 TFEVASGTNLRAALVENGIPLYNGKTE---TFNCGGNGTCGTCAVQVL 58
                6899***************99976555...367778899999999983 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.18
      Fer2_4  65 racstpvedGlkve 78 
                  ac+ +v++ ++v+
  EFC37967.1  94 LACQCQVTQDVSVQ 107
                 69999999998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       669  (0.0373138); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 753.88
//
Query:       EFC37968.1  [L=396]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.47   10.2   1.6        1.6    8.5   0.0    2.6  3  DUF588    Domain of unknown function (DUF588)


Domain annotation for each model (and alignments):
>> DUF588  Domain of unknown function (DUF588)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0     9e-05       1.6      16      52 ..      14      47 ..       4      51 .. 0.85
   2 ?   -1.2   0.4      0.09   1.6e+03     126     139 ..     101     116 ..      90     126 .. 0.73
   3 ?   -3.5   0.1      0.46   8.2e+03     120     131 ..     122     133 ..     113     143 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 9e-05
      DUF588 16 vvlalaaavvmatnkqtkevfkiqveakfsdlpafvy 52
                ++ al a+vvm+t+ q k+v+  + ++++ d ++++y
  EFC37968.1 14 AFIALSAMVVMGTAPQ-KPVS--KPTDTYGDHQQYCY 47
                567899**********.6775..78999999999999 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.09
      DUF588 126 iC..nqfgkFcervaa 139
                 iC  +++++Fc +v+ 
  EFC37968.1 101 IClgHGYKQFCTKVTK 116
                 45448999***99975 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 0.46
      DUF588 120 eaqWlkiCnqfg 131
                 + +W+++C+  g
  EFC37968.1 122 KYEWKELCKHHG 133
                 456888887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (396 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1124  (0.0626917); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 2404.08
//
Query:       EFC37969.1  [L=475]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0054   16.6   0.5     0.0092   15.9   0.5    1.3  1  Apolipoprotein  Apolipoprotein A1/A4/E domain
  ------ inclusion threshold ------
       0.14   12.2   0.8       0.29   11.2   0.3    1.8  2  Baculo_PEP_C    Baculovirus polyhedron envelope protein, PEP,
       0.32   10.9  12.8      0.029   14.3   6.6    2.5  3  STAT_alpha      STAT protein, all-alpha domain
          3    8.4  26.3        2.1    8.9   7.6    3.9  4  PRESAN          Plasmodium RESA N-terminal
        3.5    7.1   6.2        1.3    8.5   3.1    1.8  2  Exonuc_VII_L    Exonuclease VII, large subunit
          5    6.9  11.2        1.8    8.4   7.5    2.1  2  PIN_8           PIN like domain
        7.6    6.9  13.2        6.5    7.1   1.9    4.4  4  KxDL            Uncharacterized conserved protein


Domain annotation for each model (and alignments):
>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.5   3.6e-06    0.0092      34     109 ..      32     106 ..      17     140 .. 0.59

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 3.6e-06
                     HHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHCCHHCHCCHCHHHHHHHH CS
  Apolipoprotein  34 eleelrarlraeleevrarlepyrdevqeqlgqnleelrqrlapyteelrerlaadaeelqeqlavyaeelrerle 109
                       +e+++r+ + le+v    ++    +++ +++++ e+++ +++  +e+++ ++ ++e+++ +l+   ++l++  e
      EFC37969.1  32 MMKEYTERI-KVLEDVSTHFANEFKIMKKLITAHVHEVNNNIENKFKEMNKIVDSKLEKIEGRLDMAFQKLESTSE 106
                     334444555.555555555555555555555555555555555555555555555555555555555554444433 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.3   0.00011      0.29      28      82 ..      57     111 ..      43     119 .. 0.87
   2 ?   -4.3   0.0       6.7   1.7e+04      88      99 ..     437     448 ..     433     450 .. 0.50

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00011
  Baculo_PEP_C  28 qnvqilaqlatlldaietqLnalsedlksllaeldtrldtlltnLtdalnalqdt 82 
                    +  i+a + +  ++ie++++++++ + s l++++ rld ++++L+++  +l+++
    EFC37969.1  57 MKKLITAHVHEVNNNIENKFKEMNKIVDSKLEKIEGRLDMAFQKLESTSEELNKS 111
                   5566999****************************************99999943 PP

  == domain 2  score: -4.3 bits;  conditional E-value: 6.7
  Baculo_PEP_C  88 tnlnsiltnLls 99 
                   t+++s +  L s
    EFC37969.1 437 TTIESRVEKLIS 448
                   455555555554 PP

>> STAT_alpha  STAT protein, all-alpha domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   6.6   1.1e-05     0.029       7      91 ..      25     113 ..      22     119 .. 0.83
   2 ?   -1.6   0.1      0.85   2.2e+03      76      88 ..     307     319 ..     254     351 .. 0.60
   3 ?   -3.7   0.0       3.8   9.7e+03     132     152 ..     393     413 ..     392     416 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.1e-05
  STAT_alpha   7 rleelrskvqeteqdirkLedeqeeFdfqyqelqkl.....eqeraesekkelkkqkellqqmlnaLdqkRkelvdklkellnlleslqe 91 
                 +++ ++++++e  + i+ Led+  +F+ ++++++kl     ++ +++ e+k  k+ ++ +++ l+++  +     +kl+ + ++l++ q+
  EFC37969.1  25 EFRAMKKMMKEYTERIKVLEDVSTHFANEFKIMKKLitahvHEVNNNIENK-FKEMNKIVDSKLEKIEGRLDMAFQKLESTSEELNKSQH 113
                 67899*******************************877765556666655.77777777778888988888888999999888888876 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.85
  STAT_alpha  76 vdklkellnlles 88 
                  ++ +elln+++ 
  EFC37969.1 307 NSTNEELLNQTRD 319
                 3333333333332 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 3.8
  STAT_alpha 132 iwqlrqqlkkleelrqkltye 152
                 i++ r+ lkk   ++++l+y+
  EFC37969.1 393 IFEQRMDLKKNSLFENRLSYN 413
                 788899999999999999997 PP

>> PRESAN  Plasmodium RESA N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   7.6   0.00083       2.1      29      91 ..      27      89 ..      26     120 .. 0.92
   2 ?   -3.1   0.0       4.4   1.1e+04       3      30 ..     166     193 ..     165     200 .. 0.76
   3 ?    5.0   2.9     0.014        35      37     100 ..     258     335 ..     245     353 .. 0.72
   4 ?    5.2   0.4     0.011        29      14      81 ..     381     446 ..     370     456 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00083
                HHHHHHHHHHHHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      PRESAN 29 yvmknekkkyknmikkLsnyleelakkynipeeykkklwkeckneitkelkklekeynknfyn 91
                + mk + k+y + ik L  + +++a++ +i ++  +    e++n+i++++k+++k   +++++
  EFC37969.1 27 RAMKKMMKEYTERIKVLEDVSTHFANEFKIMKKLITAHVHEVNNNIENKFKEMNKIVDSKLEK 89
                679999************************************************998887765 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 4.4
                 -HHHHHHHHT-S-SEEEHHHHHHHHHHH CS
      PRESAN   3 teeelnklinslneviskkdmyiiwnyv 30 
                 tee ++ +++s   ++ ++ + +i+++ 
  EFC37969.1 166 TEEMIEGVLSSEVFEPQQETLQKIFKHC 193
                 6777888888887888888888888875 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.014
                 HHHHHHHHHHHHHHHHHHHTT--HHHHHHH..............HHHHHHHHHHHHHHHHHHHHHHHHHHHS-SEEEH CS
      PRESAN  37 kyknmikkLsnyleelakkynipeeykkkl..............wkeckneitkelkklekeynknfynllkkkklsi 100
                 +y+n +k +  + ++l++   +    ++++              +ke++n+ ++el +  + + ++ y l +++ ++i
  EFC37969.1 258 SYDNFEKAIIVMAQSLKDSSSMTPTQRTEMflvsfipnfydviqMKEVYNSTNEELLNQTRDMDNSHYFLTNNECFDI 335
                 56666666666666666666665555544455555555555555******************9999999888876543 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.011
                 S-SEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHHHHH CS
      PRESAN  14 lneviskkdmyiiwnyvmknekkkyknmikkLsnyleelakkynipeeykkklwkeckneitkelkkl 81 
                 l++ i+k d+++i+ + m++ k++    +++Ls +  el   +  ++ y  k +++ +++i+++++kl
  EFC37969.1 381 LKSLITKTDLITIFEQRMDLKKNS--LFENRLSYNAFELVLIDISNHIYGGKPFCNTYTTIESRVEKL 446
                 5788******************98..889999999888887755444455777777777777777766 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   3.1    0.0005       1.3     187     241 ..      59     122 ..      17     214 .. 0.46
   2 ?   -1.1   0.1      0.43   1.1e+03     240     251 ..     331     345 ..     250     424 .. 0.59

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0005
  Exonuc_VII_L 187 rk.rqrldeleerleralkkqlkkkrerleelkerlk...ekleekkerlkklkerle.....l 241
                   +  + +++e+++++e++ k+  k   ++le+++ rl    +kle+++e+l+k ++r +     +
    EFC37969.1  59 KLiTAHVHEVNNNIENKFKEMNKIVDSKLEKIEGRLDmafQKLESTSEELNKSQHRKSnnssfQ 122
                   2122222222223333333333333333333333331122223333333322222222111111 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.43
  Exonuc_VII_L 240 e...lleekkerlee 251
                   e   +l++++++l++
    EFC37969.1 331 EcfdILKKNRKQLKQ 345
                   011122222222222 PP

>> PIN_8  PIN like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   7.5   0.00069       1.8      39     149 ..      31     148 ..      20     160 .. 0.67
   2 ?   -2.1   0.0       1.1   2.8e+03      81      97 ..     318     334 ..     260     380 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00069
       PIN_8  39 qvalEfqrnresviskekkayedlekeleklkk....aaekkleealkkwakkkaldteelrkelkkqleelkeel.....kaeleelkksskadkeed 128
                  +++E+  +r +v+++ ++ + +  k ++kl++    ++++++e+++k+ +k    + e+++ +l+ ++++l+++      +++ ++ ++s+++ +++d
  EFC37969.1  31 KMMKEYT-ERIKVLEDVSTHFANEFKIMKKLITahvhEVNNNIENKFKEMNKIVDSKLEKIEGRLDMAFQKLESTSeelnkSQHRKSNNSSFQTPRKND 128
                 5789998.7777888777777776666655554111155666677777777777777999999999999999988877674333334445566667778 PP

       PIN_8 129 pilkkleellegkigealske 149
                 ++l+  + + e+  g+++++ 
  EFC37969.1 129 SLLQMFSPI-ERSTGKKVTSV 148
                 888887777.55666666555 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.1
       PIN_8  81 lkkwakkkaldteelrk 97 
                  ++++ +  l+++e  +
  EFC37969.1 318 RDMDNSHYFLTNNECFD 334
                 22222222222333333 PP

>> KxDL  Uncharacterized conserved protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.2      0.38   9.8e+02      61      76 ..      30      45 ..      22      74 .. 0.51
   2 ?    7.1   1.9    0.0025       6.5      26      70 ..      70     114 ..      59     117 .. 0.89
   3 ?    0.1   0.0      0.39     1e+03      22      47 ..     176     201 ..     162     209 .. 0.84
   4 ?    3.3   0.3      0.04     1e+02      20      41 ..     301     322 ..     300     355 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.38
        KxDL 61 kkdLesifkkirslka 76
                kk ++  +++i+ l++
  EFC37969.1 30 KKMMKEYTERIKVLED 45
                3333333333333322 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0025
        KxDL  26 nkknreLlelnalsqerlaklrarfkqgtkllkevkkdLesifkk 70 
                 n+ +++ +e+n++++++l+k++ r+   ++ l ++ ++L++++ +
  EFC37969.1  70 NNIENKFKEMNKIVDSKLEKIEGRLDMAFQKLESTSEELNKSQHR 114
                 66678899********************************99976 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.39
        KxDL  22 sgrlnkknreLlelnalsqerlaklr 47 
                 s +++ ++++L+++ + +  rl++l+
  EFC37969.1 176 SEVFEPQQETLQKIFKHCVLRLKDLN 201
                 77888999999999999888888876 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.04
        KxDL  20 qtsgrlnkknreLlelnalsqe 41 
                 q+  ++n++n+eLl++   +++
  EFC37969.1 301 QMKEVYNSTNEELLNQTRDMDN 322
                 778899********99877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1814  (0.101177); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.47u 0.23s 00:00:00.70 Elapsed: 00:00:00.38
# Mc/sec: 3792.10
//
Query:       EFC37970.1  [L=765]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.043   14.2   0.0        0.1   13.0   0.0    1.7  1  AAA_16    AAA ATPase domain
       0.14   12.1   0.6       0.33   10.9   0.1    1.8  2  Imm6      Immunity protein Imm6


Domain annotation for each model (and alignments):
>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   1.1e-05       0.1       2      52 ..      66     117 ..      65     200 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.1e-05
      AAA_16   2 lvGReeeleqL.lsalervrsgrpelvllsGesGvGKsslvrellralekdg 52 
                 +v Re+  e+L l+++++  s  + l +ls + G+GK++lv e+++al ++g
  EFC37970.1  66 FVNREQSCEALmLNLIRQKTSVHGMLPILSQHYGSGKTRLVHEFRKALPERG 117
                 888999999998888887777777888899999*************999983 PP

>> Imm6  Immunity protein Imm6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   3.7e-05      0.33      17      83 ..     204     271 ..     192     275 .. 0.86
   2 ?   -3.4   0.0      0.98   8.8e+03      86     111 ..     491     523 ..     485     532 .. 0.60

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 3.7e-05
        Imm6  17 ikkkddevevveeaLdvckkwleg.envtadeLydlldnedeedilefaeqeedekvenlwgtiidav 83 
                 i + + e  ++ ++L +c kw +  +++++ eLy+ll   de   le+ ++e  ++  nlw +  + +
  EFC37970.1 204 IYDLNREELIIYDCLIKCTKWASFlRKYSQFELYPLLILIDEASYLEYHYKEGYSSFVNLWESTFKTT 271
                 555666778899**********999***********************************99876655 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.98
        Imm6  86 iiwlaykkekeky......lPetl.esiddetl 111
                 ++ +a + ++ k+      lP+   + id+ +l
  EFC37970.1 491 TLIKAMNDNNMKHisilscLPQRFyDYIDKGDL 523
                 566666666666666666666654356666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (765 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.46
# Mc/sec: 4977.16
//
Query:       EFC37971.1  [L=1129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-65  219.5   0.1      4e-65  219.5   0.1    2.9  4  USP7_ICP0_bdg  ICP0-binding domain of Ubiquitin-specific prot
      7e-46  156.8   4.4      2e-45  155.3   4.4    1.8  1  UCH            Ubiquitin carboxyl-terminal hydrolase
    2.7e-41  141.6   8.3    2.7e-41  141.6   8.3    2.9  3  USP7_C2        Ubiquitin-specific protease C-terminal
      1e-24   87.7   0.4    4.9e-24   85.5   0.4    2.1  1  UCH_1          Ubiquitin carboxyl-terminal hydrolase
    0.00011   21.9   1.0       0.23   11.2   0.0    3.6  3  ubiquitin      Ubiquitin family


Domain annotation for each model (and alignments):
>> USP7_ICP0_bdg  ICP0-binding domain of Ubiquitin-specific protease 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.44   1.6e+03      48      76 ..      39      70 ..       8      83 .. 0.55
   2 !  219.5   0.1   1.1e-68     4e-65       1     240 []     632     887 ..     632     887 .. 0.94
   3 ?   -3.6   0.2       1.5   5.4e+03      91     146 ..     913     968 ..     906     987 .. 0.68
   4 ?   -1.7   0.1      0.39   1.4e+03      59      76 ..    1083    1100 ..    1038    1107 .. 0.74

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.44
  USP7_ICP0_bdg 48 Evlede....lppvkkeddillFlKlfdpekqt 76
                   ++l+ e     +p++++++ + ++K fd+++++
     EFC37971.1 39 QELD-EaaqyYEPIDESKEGVYHVKSFDANTEK 70
                   2222.1223344566666666666666666665 PP

  == domain 2  score: 219.5 bits;  conditional E-value: 1.1e-68
  USP7_ICP0_bdg   1 vRlWvmvnrqnkTvRpdqpledeeesktveelreklaskqa.elrlylEvlede............lppvkkeddillFlKlfdpekqtLsyvghv 83 
                    +R+W++++rqn+T+Rpd++++ +++++t+e+ +  ++++qa +++lylEv ++             + p   ++ illF+K ++pe+++L++vg+v
     EFC37971.1 632 QRFWKWQKRQNHTLRPDAIIKPADDASTIERKYPYVKHQQApPVELYLEVSKQTysyqkddeecvvHFPEPAQRYILLFIKEYNPEERKLNFVGTV 727
                    7******************************99877776556********993134556788999955666899********************** PP

  USP7_ICP0_bdg  84 yvskeskvsdlvpeineraglpsdtelllyEEikpnmieilklkqtlkkaelqdGdIicfqkelse.e.ekdelpdakeyydfllnrveVtFkpke 177
                    y+++ s+vs+++p+i+  +g ++d+++++ EEikp+mi+ ++++q++k+a+lq+GdI+ +q+  +  + +k+ +p+ak+yyd+l nrv+V+++++e
     EFC37971.1 728 YADMLSEVSEVIPSIKALIGADEDDDIHIVEEIKPKMIDDVRIDQSFKDAQLQSGDILAVQRVPKGtDlSKYPIPTAKSYYDYLNNRVSVEIRKLE 823
                    *************************************************************9998854899************************* PP

  USP7_ICP0_bdg 178 kpkdeeftleLskkmtYdqlaekvaekLkvdptklrfttvnaasgkpk.apikrsnqetlkdil 240
                    +p ++   +eL k+m+Y++l++k++++L+vd + lr+t ++++s++p  +p+k+++ +tlkd++
     EFC37971.1 824 DPLKNVAVVELLKNMEYKELTDKLGSALEVDGNFLRLTGHHPYSEGPLeQPFKSNSGSTLKDMI 887
                    ***********************************************99*****9999****96 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 1.5
  USP7_ICP0_bdg  91 vsdlvpeineraglpsdtelllyEEikpnmieilklkqtlkkaelqdGdIicfqke 146
                     + +v+ +n++ +  ++ ++lly + k n  ++l   +     e+++  I++ q +
     EFC37971.1 913 KELIVTWMNSKCQDVEKFKFLLYPDQKVNDLKQLIEAKVNGRREIENSTIVISQIS 968
                    45566667777777777777788887777666655555556678888888877755 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.39
  USP7_ICP0_bdg   59 keddillFlKlfdpekqt 76  
                      edd llF  lfd ekq+
     EFC37971.1 1083 LEDDSLLFCELFDKEKQS 1100
                     57899********99996 PP

>> UCH  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  155.3   4.4   5.6e-49     2e-45       2     257 .]     211     529 ..     210     529 .. 0.89

  Alignments for each domain:
  == domain 1  score: 155.3 bits;  conditional E-value: 5.6e-49
                 EES-SSSTHHHHHHHHHHHTSHHHHHHHHTCHHCCSSTCCCCC-.TT.TTS.TTHHHHHHHHHHHHHHSH-CCEE--HHHHHHHHHHSGGGTSSSTCEH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH   2 GlsNlGntCymnsvlQcLfsipelrdyllsleevkkesrnkkelnesnplgkkgelakalkdlfkellkskskavsPkklkktlsklaksfsgykqqDa 100
                 Gl+N G+tCymns+lQ L+ +  +r+ +++  + +++++ +++            +  al ++f  l+   + av +k+l+k++++   +  ++ q+D+
  EFC37971.1 211 GLQNQGATCYMNSLLQTLYLLTYFRKSVYK-MPIDENEKPQDS------------IPLALMRVFFRLQ-FDKGAVDTKELTKSFGWDTID--SFLQHDV 293
                 9************************88877.344444444433............7889999999999.4689*************9988..99***** PP

                 HHHHHHHHHHHHHHHCCHCCCHHHHHHCCCTTSHHHHHH-EEEEE...................................................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...................................................... RF
         UCH 101 qEflaflLdqlhedlnrevaeekwkkhlkrndslitdlfegqlks...................................................... 145
                 qEf ++l+d+l++++++           + +++++ ++feg+ k+                                                      
  EFC37971.1 294 QEFARVLIDNLEKKMEK-----------TDQKEVMRQIFEGMCKNyikcinvdyessrkepfydlqlnvkgcknvaesfdqyileetlqgenqyqaegh 381
                 *****************...........89999****************************************************************** PP

                 .......EEEEEEB-SEEEEEEESEEETEE...EEE--SEEB--SEEE-GGGBSS-BTTS-TCS-BEEEEEEEEEESCTTSEEEEEEEECT.TTTEEEE CS
                 .......xxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxx RF
         UCH 146 .......klklkrlPeiLiihlkRfsynss...ksKlntkvefpeeldlssylaeekkkkteekkkYeLiavvvHsGslssGHYvayikne.kngkWyk 233
                         +++ +lP++L++hlkRf+y+       K+n++ efp+e+dl +yl+e++++k+e  ++Y L++v+vHsG +s+GHY+ +++ + ++ +W+k
  EFC37971.1 382 glqdakkGTNFLKLPPVLMLHLKRFEYDYIrdlIYKINDRYEFPLEIDLGKYLSEDSEQKKE-DNTYVLFSVLVHSGDVSGGHYYNFARPYiNEDRWFK 479
                 *******99******************8888899*******************988887755.566********************8884414567*** PP

                 EETTEEEEE-HH.......................CCCTT......CEEEEEE CS
                 xxxxxxxxxxxx.......................xxxxx......xxxxxxx RF
         UCH 234 ydDetvkevkee.......................eevls......sayiLfY 257
                 +dDe+v ev+e+                       +   s      +ay+L+Y
  EFC37971.1 480 FDDEKVYEVNESlavqdnyggeakkskmfwlssnpN---SvykkftNAYMLLY 529
                 **********99999999888887777777765552...14457889****99 PP

>> USP7_C2  Ubiquitin-specific protease C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1      0.98   3.5e+03      44     102 ..     484     550 ..     481     577 .. 0.69
   2 ?    0.8   0.0     0.092   3.3e+02     137     162 ..     610     637 ..     594     702 .. 0.60
   3 !  141.6   8.3   7.4e-45   2.7e-41       2     206 .]     897    1116 ..     896    1116 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.98
     USP7_C2  44 tvkdlleelqkkvkl.seeeskklrllevsnhkiqkvlkedealeslnds......ttlraeeip.e 102
                 +v ++ e l+ + +   e +++k+  l  + + ++k +++ + l  +++s        + ++eip +
  EFC37971.1 484 KVYEVNESLAVQDNYgGEAKKSKMFWLSSNPNSVYKKFTNAYMLLYIRKSaisnmiAPVEVDEIPsH 550
                 5666666777777774455788888888899999999999999999966655555555555555533 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.092
     USP7_C2 137 egEtfsetkeRlqkrlgvk..dkeFeki 162
                 ++ tf+e+ke +++  g+k  ++ F k+
  EFC37971.1 610 REGTFAELKEQIETLYGIKaeQQRFWKW 637
                 4445666666666666655323333333 PP

  == domain 3  score: 141.6 bits;  conditional E-value: 7.4e-45
     USP7_C2    2 lyYevLsislkElEnkksikvtwlseklkkeeelellvpkngtvkdlleelqkkvklsee.eskklrllevsnhkiqkvlkedealesl..ndsttl 95  
                  lyYe+L+ ++ ++Enkk++ vtw+++k+++ e++++l+  +++v+dl++ +++kv+   e e++ + + ++sn+ki+k+l+ +e +++l  n+  t+
  EFC37971.1  897 LYYEILDEPIFNVENKKELIVTWMNSKCQDVEKFKFLLYPDQKVNDLKQLIEAKVNGRREiENSTIVISQISNFKISKLLTGEELIKTLatNKGETI 993 
                  9********************************************************8887****************************99999*** PP

     USP7_C2   96 raeeipedeleleed.....e..kliqvfhFskeps..kthGiPFlfklkegEtfsetkeRlqkrlgvkdkeFekiKfalvtrskykpeyledddlv 183 
                  raeei ++el++ ++     e  +++qv+h  ke++  + +G P ++++k +Et++++k+Rlq++l+v d +++++Kf ++ ++k  + +ledd+ +
  EFC37971.1  994 RAEEILNEELSIITSshnltEntRILQVQHICKETTgyRLFGNPSVLVVKTEETLGDVKKRLQDKLQVRDIDYKRYKFYFIVNMKI-KDALEDDS-L 1088
                  **********8855555565257***********654499*********************************************5.57999998.4 PP

     USP7_C2  184 ll.dllsk.eddl...dlLgLdHpdksr 206 
                  l+ +l+ k ++++   ++L+L+H d ++
  EFC37971.1 1089 LFcELFDKeKQSTnvdVVLALEHKDPTP 1116
                  44444444222225579******99875 PP

>> UCH_1  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.5   0.4   1.4e-27   4.9e-24       1     320 []     210     485 ..     210     485 .. 0.83

  Alignments for each domain:
  == domain 1  score: 85.5 bits;  conditional E-value: 1.4e-27
                 xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1   1 sGLEnhivnsYlNslLQvlyfipplr.nlalshlakeckkehcLlcElgflfdmldkakglncqasnFlralssipeasalglileeeeetekssaisl 98 
                 +GL n+ +++Y+NslLQ+ly ++ +r  +++  + ++ k ++++   l  +f  l+ +kg+ + +++++++++    ++++  +l++  +         
  EFC37971.1 210 AGLQNQGATCYMNSLLQTLYLLTYFRkSVYKMPIDENEKPQDSIPLALMRVFFRLQFDKGA-VDTKELTKSFG----WDTIDSFLQH--D--------- 292
                 7*************************9999999*99****************999999975.8999*******....7788888776..3......... PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxx RF
       UCH_1  99 ssliqsfnrflldqlekelketkknsseeesaieqllgtkaettirclkCgseksrksstlvldlkyPkpsnekkeakvtf.asilksslerekttraw 196
                    +q+f r+l+d+lek+ ++t      +++ + q+++   ++ i+c++   e+srk+ ++ l+l+   + +  k+   +f + il+++l+ e++ +a 
  EFC37971.1 293 ---VQEFARVLIDNLEKKMEKTD-----QKEVMRQIFEGMCKNYIKCINVDYESSRKEPFYDLQLNV--KGC--KNVAESFdQYILEETLQGENQYQA- 378
                 ...678************99976.....6788*********************************66..444..444457746778899998777765. PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1 197 CekCkryqpteqrktvknlPpvLalnakleeeeelelwkt.......knwlpleiklsldedknleeklkeerekakaekeikvYeLqsvvvhigdske 288
                   + +  q  +++ ++ +lPpvL+l++k++e +   + ++       +  +plei+l     k     l e++   +++ke ++Y+L+sv vh gd + 
  EFC37971.1 379 --EGHGLQDAKKGTNFLKLPPVLMLHLKRFEYD---YIRDliykindRYEFPLEIDLG----K----YLSEDS---EQKKEDNTYVLFSVLVHSGDVS- 460
                 ..56899*********************98554...4444433444347888888882....2....222222...34566789***********877. PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1 289 sghLvslvkvaekelerdppesqWylFNDflV 320
                  gh++ +++   ++ +    e++W++F+D +V
  EFC37971.1 461 GGHYYNFAR---PYIN----EDRWFKFDDEKV 485
                 *********...5543....79*******766 PP

>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.0   6.5e-05      0.23      13      41 ..     606     634 ..     601     635 .. 0.89
   2 !    6.3   0.1    0.0022         8       4      32 ..     923     951 ..     920     960 .. 0.89
   3 ?   -0.1   0.0      0.23   8.1e+02      15      34 ..    1042    1061 ..    1035    1071 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6.5e-05
                 EEEETTSBHHHHHHHHHHHHTSSGGGEEE CS
   ubiquitin  13 leveesdtveelKekiaekegipaeqqrL 41 
                 +++ ++ t +elKe+i+   gi aeqqr+
  EFC37971.1 606 IKFLREGTFAELKEQIETLYGIKAEQQRF 634
                 566778899******************97 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0022
                 EETTSEEEEEEEETTSBHHHHHHHHHHHH CS
   ubiquitin   4 ktldgkkitleveesdtveelKekiaeke 32 
                 k++d +k+ + + ++++v +lK+ i++k 
  EFC37971.1 923 KCQDVEKFKFLLYPDQKVNDLKQLIEAKV 951
                 568999********************987 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.23
                  EETTSBHHHHHHHHHHHHTS CS
   ubiquitin   15 veesdtveelKekiaekegi 34  
                  v+ ++t+ ++K+++++k ++
  EFC37971.1 1042 VKTEETLGDVKKRLQDKLQV 1061
                  78899999999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       878  (0.0489709); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.83u 0.27s 00:00:01.10 Elapsed: 00:00:00.47
# Mc/sec: 7242.17
//
Query:       EFC37972.1  [L=598]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.079   11.5   4.9        0.1   11.1   4.9    1.2  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   4.9   5.8e-06       0.1     231     353 ..      34     174 ..       7     291 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.8e-06
    Macoilin 231 pvalsknnhslnkk......dsslklpeleyrekkksakssrsdskkkhehnesvdsklqekeymenkskskrlsksessgsesellveesvkskssss 323
                 ++ l++nn s ++       +ss++l++l+ ++++ s++ + s+s+      ++++s +   + +e k++s ++ k ++ g +s++ ++++v sk+ ss
  EFC37972.1  34 SKPLNNNNCSSSSAvkgivgSSSENLSTLKGKDSSLSKNGTPSSSQ------TQLHSSKIMSSSIEGKANSVEVPKATNGGVKSNTVKQNHVPSKQISS 126
                 4445555555555455666677777777777777555555433332......23444555556688999999999999999999999999999999988 PP

    Macoilin 324 ssssn..................knskkasagsagssnssskkhsess 353
                  s+                     +  ++ ++s g++ns +k+ ++  
  EFC37972.1 127 VSNGDkikspkniplktdpasqkDKLTRSITKSPGITNSQPKESKSLI 174
                 888754555555555554433321111222223333333333333322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (598 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       665  (0.0370907); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.47
# Mc/sec: 3820.93
//
Query:       EFC37973.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0017   18.3   0.0      0.095   12.8   0.0    3.1  3  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.02   3.5e+02       1      20 [.     148     167 ..     148     170 .. 0.78
   2 ?   -1.7   0.0       0.2   3.6e+03       7      20 ..     242     257 ..     241     260 .. 0.77
   3 !   12.8   0.0   5.3e-06     0.095       1      28 []     276     304 ..     276     304 .. 0.93

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.02
                 BSSEEEEEEETTTEEEEEE.C CS
         NHL   1 fnyPhGvavdsnGdiyVaD.s 20 
                 fn+ +G++ +   +iyV D +
  EFC37973.1 148 FNQIWGLTRF-KTEIYVVDhR 167
                 7888888888.7789999954 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.2
                 EEEE.TTTEEEEEE.C CS
         NHL   7 vavd.snGdiyVaD.s 20 
                 v++  ++  iy +D +
  EFC37973.1 242 VCYEkKTRLIYLTDmY 257
                 677778889****955 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 5.3e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 ++yP Gva++ +nG+++ ++++   + v+
  EFC37973.1 276 LSYPYGVAINdKNGELFLCNTGACEILVY 304
                 68999*****************9999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       500  (0.0278878); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 1830.71
//
Query:       EFC37974.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-24   86.7  22.9    5.2e-15   55.8  16.0    2.1  2  HlyIII    Haemolysin-III related


Domain annotation for each model (and alignments):
>> HlyIII  Haemolysin-III related
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.8  16.0   2.9e-19   5.2e-15       1     165 [.      94     256 ..      94     271 .. 0.83
   2 !   35.2   0.5   5.6e-13     1e-08     171     221 ..     314     364 ..     300     367 .. 0.89

  Alignments for each domain:
  == domain 1  score: 55.8 bits;  conditional E-value: 2.9e-19
      HlyIII   1 fslhnEtlniwtHllgailfivlailllslaevken...sklakvvvlvfllgallcllcSalyHtlsihseeklrkffaklDysgIslliagsylpli 96 
                 f+lhnEt+niw H+++ +++ v+a+++  ++ ++ n   + l++++++++ ++ ++ +++Sa+yHt  ++s  +  +f+   D  gI++l+ g     i
  EFC37974.1  94 FTLHNETINIWNHFIPSLIYCVFAFYINHYV-TEANpnaKFLDRASFIFYCVTGIFTFGFSAMYHTWRMNSI-NDYHFCLLCDIRGIVVLVSGANALSI 190
                 799************9888755555544444.44444688899*****************************.8999999******************* PP

      HlyIII  97 lyalakapkagllylslilalgvlgiisklvplfsrpearplravlfillgllgvipllhlllvltqlg 165
                  + +++   ++++y ++ ++l+v+ i+    ++  r++    r+++f +  l+ ++ l+h+++  +  +
  EFC37974.1 191 TLQIKDYEYWQWIYSTVNIVLVVFFIFWIRKMV--RERLTNQRTIYFTIYSLIPLFTLVHRFILQS-SS 256
                 ****99999*****9999999998887666666..9999*********************554433.33 PP

  == domain 2  score: 35.2 bits;  conditional E-value: 5.6e-13
      HlyIII 171 alvllvlggvlylvGavfYalrvPErlkpgkfdivghsHqiFHvfvvlgal 221
                  + l+++ ++l  +G ++ + + PEr+ p kfd +g sHqiFH++ v +++
  EFC37974.1 314 LVQLFIVNYLLLGLGMFIRGYKAPERWIPYKFDLFGASHQIFHFMSVYASF 364
                 56788999999999*******************************999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       992  (0.0553294); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 2288.54
//
Query:       EFC37975.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-09   38.4  21.8    4.9e-08   33.0   5.9    3.7  4  Kazal_2   Kazal-type serine protease inhibitor domain
      0.002   18.1   6.9      0.002   18.1   6.9    4.3  4  Kazal_1   Kazal-type serine protease inhibitor domain


Domain annotation for each model (and alignments):
>> Kazal_2  Kazal-type serine protease inhibitor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.1   2.5         2   1.8e+04       1       8 [.      66      73 ..      66      75 .. 0.82
   2 ?   -3.2   0.0       1.1     1e+04      32      40 ..     207     215 ..     206     223 .. 0.75
   3 !   19.4   7.9   9.3e-08   0.00083       2      49 .]     358     396 ..     357     396 .. 0.89
   4 !   33.0   5.9   5.5e-12   4.9e-08       3      49 .]     411     452 ..     409     452 .. 0.96

  Alignments for each domain:
  == domain 1  score: -5.1 bits;  conditional E-value: 2
                -CCCGCCT CS
     Kazal_2  1 nceckCpe 8 
                nc+  Cp 
  EFC37975.1 66 NCCNVCPV 73
                79999995 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.1
                 CCCCSTT-- CS
     Kazal_2  32 gCllkrksk 40 
                 gC++++k++
  EFC37975.1 207 GCKKSKKIH 215
                 799999998 PP

  == domain 3  score: 19.4 bits;  conditional E-value: 9.3e-08
                 CCCGCCT-----EEETTTEEESSHHHHHHHCCCCSTT--..EEECSS- CS
     Kazal_2   2 ceckCpeleydpVCGsDgktYtseCkLqaagCllkrkskkelkydGsC 49 
                 ++c+C+ +ey+pVC  Dg+t +++C    a+C     ++  +k++G+C
  EFC37975.1 358 VPCACS-AEYHPVCTKDGVTVFNLC---SAKC---LGLE--VKHEGEC 396
                 79****.******************...****...4555..6699999 PP

  == domain 4  score: 33.0 bits;  conditional E-value: 5.5e-12
                 CCGCCT-----EEETTTEEESSHHHHHHHCCCCSTT--..EEECSS- CS
     Kazal_2   3 eckCpeleydpVCGsDgktYtseCkLqaagCllkrkskkelkydGsC 49 
                 + +C+++ ++pVCG Dg+tY++ C    a+C ++ k +   k++G+C
  EFC37975.1 411 CDQCKNVPKKPVCGVDGVTYPNTC---VAKCVTSGKFE--MKRKGKC 452
                 789*********************...***********..******* PP

>> Kazal_1  Kazal-type serine protease inhibitor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.25   2.2e+03       8      16 ..     263     271 ..     253     273 .. 0.82
   2 ?   -3.1   0.2      0.95   8.5e+03       2      14 ..     279     290 ..     278     291 .. 0.69
   3 !    9.8   9.2   8.9e-05       0.8       8      31 ..     361     385 ..     347     398 .. 0.75
   4 !   18.1   6.9   2.2e-07     0.002      14      49 .]     420     452 ..     404     452 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.25
                 S-TSSS--E CS
     Kazal_1   8 aCpreyepv 16 
                  Cpr y++v
  EFC37975.1 263 KCPRGYKKV 271
                 4*****997 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.95
                 SCCTTTS-TSSS- CS
     Kazal_1   2 seykekaCpreye 14 
                  + + k Cp+ y+
  EFC37975.1 279 IKINMK-CPKGYR 290
                 556666.**9886 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 8.9e-05
                 S-TSSS--EEETTSEEESSHHHH.H CS
     Kazal_1   8 aCpreyepvCGtDgkTYsneCll.C 31 
                 aC++ey pvC +Dg+T  n C   C
  EFC37975.1 361 ACSAEYHPVCTKDGVTVFNLCSAkC 385
                 7******************998666 PP

  == domain 4  score: 18.1 bits;  conditional E-value: 2.2e-07
                 --EEETTSEEESSHHHH.HHHHHTTSSS--EEECS-- CS
     Kazal_1  14 epvCGtDgkTYsneCll.CaengkkgtklqlehdGeC 49 
                 +pvCG Dg+TY n+C+  C  +     k+++++ G+C
  EFC37975.1 420 KPVCGVDGVTYPNTCVAkCVTS----GKFEMKRKGKC 452
                 8**************9888544....45566666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       877  (0.0489152); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.28s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2892.76
//
Query:       EFC37976.1  [L=198]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-17   62.5   0.0     0.0037   17.2   0.0    4.5  4  LRR_6            Leucine Rich repeat
    9.4e-11   41.8   0.1    0.00073   19.9   0.0    2.7  2  LRR_4            Leucine Rich repeats (2 copies)
    1.9e-09   37.2   0.3     0.0039   16.9   0.1    3.2  3  LRR_8            Leucine rich repeat
    8.9e-05   22.5   0.0         92    4.2   0.0    5.1  5  LRR_1            Leucine Rich Repeat
  ------ inclusion threshold ------
      0.036   14.4   0.3         19    5.7   0.0    3.4  2  CLU_N            Mitochondrial function, CLU-N-term
      0.037   14.1   0.1        9.8    6.3   0.0    2.2  2  HydF_dimer       Hydrogen maturase F dimerization domain
      0.044   13.8   2.8         22    5.1   0.1    4.1  4  ApoB100_C        Apolipoprotein B100 C terminal
      0.047   14.3   5.5      0.053   14.1   4.2    1.9  2  SAS-6_N          Centriolar protein SAS N-terminal
       0.06   13.0   0.9        2.4    7.7   0.1    2.5  2  Pep_deformylase  Polypeptide deformylase
      0.063   13.4   0.4       0.12   12.4   0.4    1.5  1  Dynein_heavy     Dynein heavy chain region D6 P-loop domain
       0.21   11.5   0.5       0.35   10.8   0.5    1.3  1  F-box-like       F-box-like
       0.45   10.3   2.8         13    5.5   0.2    2.5  2  UPF0193          Uncharacterised protein family (UPF0193)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   2.5e-06    0.0037       5      23 ..     101     119 ..      98     120 .. 0.91
   2 !   15.5   0.0   8.9e-06     0.013       5      24 .]     125     144 ..     122     144 .. 0.92
   3 !   16.1   0.0   5.8e-06    0.0086       5      23 ..     149     167 ..     146     168 .. 0.91
   4 !    8.3   0.0    0.0017       2.6       5      19 ..     173     187 ..     170     192 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 2.5e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L+++gN+Ig eGa+ +
  EFC37976.1 101 LTSLSIAGNQIGVEGAKFI 119
                 9***************987 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 8.9e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+ +N+Ig eGa+ ++
  EFC37976.1 125 LTSLDIHDNGIGVEGAKYIS 144
                 9***************9885 PP

  == domain 3  score: 16.1 bits;  conditional E-value: 5.8e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++++N+I  eGa+ +
  EFC37976.1 149 LTSLNIADNQIHVEGAKFI 167
                 9***************977 PP

  == domain 4  score: 8.3 bits;  conditional E-value: 0.0017
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt+L++ +N+Ig eG
  EFC37976.1 173 LTSLNIYYNGIGVEG 187
                 9***********999 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   4.9e-07   0.00073       1      35 [.      99     134 ..      99     139 .. 0.83
   2 !   19.2   0.0   8.2e-07    0.0012       1      33 [.     147     181 ..     147     189 .. 0.84

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 4.9e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnl 35 
                 ++L++L++++Nq+   +  + + +++L++Ld+++N  
  EFC37976.1  99 KQLTSLSIAGNQIGVEGAkFISeMKQLTSLDIHDN-G 134
                 58************766696655*********777.4 PP

  == domain 2  score: 19.2 bits;  conditional E-value: 8.2e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgN 33 
                 ++L++L++++Nq+   +  + + +++L++L++  N
  EFC37976.1 147 KQLTSLNIADNQIHVEGAkFISeMKQLTSLNIYYN 181
                 58************766696655*********777 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.79   1.2e+03       9      22 ..      17      30 ..      15      42 .. 0.80
   2 !   14.7   0.0   1.3e-05     0.019      24      60 ..      98     134 ..      90     135 .. 0.64
   3 !   16.9   0.1   2.6e-06    0.0039       2      37 ..     148     183 ..     147     185 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.79
                TTS--SEE-TTSST CS
       LRR_8  9 snNrltslddeaFk 22
                ++  ++ +dd++F 
  EFC37976.1 17 CFEIISMIDDSWFI 30
                56668999999995 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.3e-05
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +++L++L++  N++ +  ++ +s +++L+sLd+ +N 
  EFC37976.1  98 MKQLTSLSIAGNQIGVEGAKFISEMKQLTSLDIHDNG 134
                 6666666666666666666666666666666666665 PP

  == domain 3  score: 16.9 bits;  conditional E-value: 2.6e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37 
                 +LtsL++ +N++++ + ++ + +++L++L++ +N +
  EFC37976.1 148 QLTSLNIADNQIHVEGAKFISEMKQLTSLNIYYNGI 183
                 799****************************99955 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1      0.52   7.8e+02       7      15 ..      31      39 ..      24      47 .. 0.82
   2 ?    2.5   0.0      0.22   3.2e+02       1      15 [.     100     114 ..     100     122 .. 0.77
   3 ?    3.6   0.0     0.099   1.5e+02       1      18 [.     124     141 ..     124     146 .. 0.76
   4 ?    3.5   0.0       0.1   1.5e+02       1      12 [.     148     159 ..     148     169 .. 0.80
   5 ?    4.2   0.0     0.061        92       1      20 [.     172     191 ..     172     194 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.52
       LRR_1  7 Lsnnpllgl 15
                L+n++l+++
  EFC37976.1 31 LNNCCLISK 39
                899**9765 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.22
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L + +n+++  
  EFC37976.1 100 QLTSLSIAGNQIGVE 114
                 599*******99655 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.099
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld+ +n ++  ++ 
  EFC37976.1 124 QLTSLDIHDNGIGVEGAK 141
                 599*******98666555 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.1
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L++ +n++
  EFC37976.1 148 QLTSLNIADNQI 159
                 599*******97 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.061
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++ +n ++  ++ ++
  EFC37976.1 172 QLTSLNIYYNGIGVEGSKYI 191
                 599*******9977777665 PP

>> CLU_N  Mitochondrial function, CLU-N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.1     0.035        52      14      28 ..     118     132 ..      89     162 .. 0.57
   2 ?    5.7   0.0     0.013        19      14      42 ..     166     197 ..     164     198 .] 0.81

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.035
       CLU_N  14 elpstkylTnyhLky 28 
                 +++++k+lT+ ++  
  EFC37976.1 118 FISEMKQLTSLDIHD 132
                 345555666666644 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.013
       CLU_N  14 elpstkylTnyhLkye..ng.ngerlnefvtl 42 
                 +++++k+lT+ +++y+  ++  ++ ++e+++l
  EFC37976.1 166 FISEMKQLTSLNIYYNgiGVeGSKYISEMKQL 197
                 67899**********98766677888888776 PP

>> HydF_dimer  Hydrogen maturase F dimerization domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.1     0.011        17      15      92 ..      52     130 ..      43     131 .. 0.86
   2 ?    6.3   0.0    0.0066       9.8      54      92 ..     140     178 ..     136     182 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.011
  HydF_dimer  15 vvpidseaPkgRl.ilpqvqviRdilDekaiavvvkeseleaalkslkrkpklvitDsqvvkkvaeivpkdvklttfsi 92 
                 v+  +++  + R+  l ++q +  i++ k   + +++ +  ++++++k+  +l i+  q+  + a+ + +  +lt+  i
  EFC37976.1  52 VIQFNEQFTENRIeLLMKSQFMNSIVNVKFSYMLLNSPDQVKFITEMKQLTSLSIAGNQIGVEGAKFISEMKQLTSLDI 130
                 6666666677777346899*****************************************9999999999999998765 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0066
  HydF_dimer  54 eaalkslkrkpklvitDsqvvkkvaeivpkdvklttfsi 92 
                 +++++++k+  +l i+D q+  + a+ + +  +lt+  i
  EFC37976.1 140 AKYISEMKQLTSLNIADNQIHVEGAKFISEMKQLTSLNI 178
                 678999*****************************9988 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1     0.015        22      19      32 ..      93     106 ..      80     111 .. 0.84
   2 ?    2.4   0.0      0.11   1.6e+02      19      32 ..     117     130 ..     109     133 .. 0.87
   3 ?   -0.4   0.0      0.76   1.1e+03      19      32 ..     141     154 ..     139     162 .. 0.83
   4 ?    3.2   0.1     0.057        85      13      32 ..     159     178 ..     148     181 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.015
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  LsI
  EFC37976.1  93 KFITEMKQLTSLSI 106
                 9***********99 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.11
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  L I
  EFC37976.1 117 KFISEMKQLTSLDI 130
                 9********99987 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.76
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k i+e k+L  L I
  EFC37976.1 141 KYISEMKQLTSLNI 154
                 78999999998887 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.057
   ApoB100_C  13 lsdyyEkliaeskrLiDLsI 32 
                 +     k+i+e k+L  L I
  EFC37976.1 159 IHVEGAKFISEMKQLTSLNI 178
                 5555569********99987 PP

>> SAS-6_N  Centriolar protein SAS N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   4.2   3.5e-05     0.053       5      77 ..      23      95 ..      16     133 .. 0.68
   2 ?   -2.0   0.0       3.7   5.5e+03      34      43 ..     160     169 ..     139     182 .. 0.57

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 3.5e-05
                EEETTEEEEEEEEEEEHHHHHHHHHHCTB-S-CC.CHHHHHHHHHHHH...............HHS...SSEEEECCTTTSSEEEEEEE CS
     SAS-6_N  5 ltdenDlfflytleiseedFeelkeeqnLlvdFa.eFpsklikllnsc...............qkpekkkylavlslekdegqakLsiv 77
                ++d++ +++   + is++ F+ +ke  +L ++F+ +F+++ i+ll ++                                ++  + +++
  EFC37976.1 23 MIDDSWFILNNCCLISKQWFNVIKERSKLVIQFNeQFTENRIELLMKSqfmnsivnvkfsymlL----------------NSPDQVKFI 95
                444454555567899******************647************4433222222222210................223333333 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 3.7
                 -S-CCCHHHH CS
     SAS-6_N  34 lvdFaeFpsk 43 
                 +v+ a+F+s+
  EFC37976.1 160 HVEGAKFISE 169
                 3333333333 PP

>> Pep_deformylase  Polypeptide deformylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.1    0.0016       2.4      34      64 ..      94     124 ..      36     137 .. 0.89
   2 ?    3.6   0.0     0.031        46      35      66 ..     143     174 ..     139     185 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0016
                      HHHHHHHCT-SEEEGGGGT--BSEEEEECCS CS
  Pep_deformylase  34 mletmkeakgvgLAApQigvnkrlfvielps 64 
                       + +mk+ + + +A +Qigv+ + f+ e+++
       EFC37976.1  94 FITEMKQLTSLSIAGNQIGVEGAKFISEMKQ 124
                      577899999************9999988876 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.031
                      HHHHHHCT-SEEEGGGGT--BSEEEEECCSS- CS
  Pep_deformylase  35 letmkeakgvgLAApQigvnkrlfvielpsee 66 
                      +++mk+ + +++A +Qi+v+ + f+ e+++ +
       EFC37976.1 143 ISEMKQLTSLNIADNQIHVEGAKFISEMKQLT 174
                      6789999*************999999888765 PP

>> Dynein_heavy  Dynein heavy chain region D6 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.4   8.2e-05      0.12      53      95 ..      24      71 ..      20     102 .. 0.59

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 8.2e-05
                  HHT-EEEEE-GGG-.CCCHHHHHHH...........HHTT-EEEEEEE CS
  Dynein_heavy 53 kegsWvlLqNchla.pswlkeLekileel....eeklhssfRlwltse 95
                   ++sW +L+Nc l+ ++w + +++  + +    e+ ++++  l + s+
    EFC37976.1 24 IDDSWFILNNCCLIsKQWFNVIKERSKLViqfnEQFTENRIELLMKSQ 71
                  579**********989**999998854223333333333334444333 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.5   0.00024      0.35       6      36 ..      14      46 ..      14      51 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00024
  F-box-like  6 dEiLlqIFsyLpps..dLlrlalVCrrWrrval 36
                d+++ +I s +++s   L +++l +++W +v+ 
  EFC37976.1 14 DDVCFEIISMIDDSwfILNNCCLISKQWFNVIK 46
                68999999999888644777**********995 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.1     0.014        21     171     209 ..     115     153 ..     109     161 .. 0.89
   2 ?    5.5   0.2    0.0089        13     170     205 ..     162     197 ..     155     198 .] 0.92

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.014
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklrelealdkkr 209
                  ++F++eM++L   + + + I  e ++ + e+++l + +
  EFC37976.1 115 GAKFISEMKQLTSLDIHDNGIGVEGAKYISEMKQLTSLN 153
                 579*******************************98766 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0089
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklreleal 205
                 e ++F++eM++L   + Y + I  e s+ + e+++l
  EFC37976.1 162 EGAKFISEMKQLTSLNIYYNGIGVEGSKYISEMKQL 197
                 5579*****************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (198 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       655  (0.036533); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1234.42
//
Query:       EFC37977.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-06   28.7   0.0    3.4e-06   27.6   0.0    1.6  1  Lipase_GDSL_2  GDSL-like Lipase/Acylhydrolase family
     0.0012   18.8   0.4       0.76    9.8   0.0    2.7  3  CE2_N          Carbohydrate esterase 2 N-terminal
     0.0054   16.7   0.0     0.0098   15.9   0.0    1.4  1  Lipase_GDSL    GDSL-like Lipase/Acylhydrolase


Domain annotation for each model (and alignments):
>> Lipase_GDSL_2  GDSL-like Lipase/Acylhydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   0.0   5.7e-10   3.4e-06       1     100 [.     169     298 ..     169     323 .. 0.66

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 5.7e-10
                    EEESHHHHTCTTB.........CCHCHHCCCCCCCHHHTT-EEEEE.EEHCCH-H........................HHHHHHHHCTGGG-TSE CS
  Lipase_GDSL_2   1 alGDSiTaGygad.........gggrsypaylarllaarlgldvvnnlgvsGatt......................allrllerlrdllrlkpdl 65 
                    ++GDSiT+ yg +         ++++   ++  ++ a+  +++++ +   sG  +                       + + +  ++   ++ pd+
     EFC37977.1 169 FIGDSITCAYGNMgkppcaytpATQNVHESF-VEKTARYVNASEIHIECWSGKGVvrnfadknttsvdpfpvyyprtLANDANSVWEFRKTFIPDI 263
                    79*********98888887776555555555.66666666666666655666644333333333445655555444444444444445566666** PP

                    EEEE--CCCCCTT--HHHHHHH..HHHHHHHHCCC CS
  Lipase_GDSL_2  66 vtiliGtNDlgrgvpaaaaaandnleelidalraa 100
                     +i++GtND+ + + ++  +  +++++++d +  +
     EFC37977.1 264 AVITLGTNDFSTAPRPSFEQFSNGYQKFLDFIFGK 298
                    *********87777777666666799999977665 PP

>> CE2_N  Carbohydrate esterase 2 N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0015       8.8       3      27 ..      26      49 ..      24      55 .. 0.89
   2 !    9.8   0.0   0.00013      0.76      77     103 ..     120     146 ..     112     152 .. 0.83
   3 ?   -3.1   0.0       1.3   7.6e+03      19      37 ..     162     180 ..     160     211 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0015
                S--EE-TTS-EEE-STT-EEEEEEE CS
       CE2_N  3 GRvdfsdpgaprfawpGtsvefrft 27
                GR+ ++++ a++f+w+G  ++++ft
  EFC37977.1 26 GRFLRDKS-AIVFDWSGFIISTQFT 49
                99998766.9************998 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00013
                 EEEEEEEE-S-GGG--EEEEEEEEE.E CS
       CE2_N  77 ehtvrlvkrtEaeagkteflgfvldeg 103
                  +++++ krtEa +g ++f+g+++ ++
  EFC37977.1 120 VVEIEIEKRTEAMVGVVQFYGITFLQS 146
                 5789*****************998665 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.3
                 T-EEEEEEEEEEEEEEEEE CS
       CE2_N  19 GtsvefrftGtslsvrlkd 37 
                  t +++ f G+s++++  +
  EFC37977.1 162 STDLKIEFIGDSITCAYGN 180
                 5777888888888877666 PP

>> Lipase_GDSL  GDSL-like Lipase/Acylhydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   1.6e-06    0.0098       1     108 [.     167     293 ..     167     315 .. 0.54

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.6e-06
                  EEEEESHHHHTT..............................................THHHHHHHCCCCEECCCTTC.GCEEEEEEECTTHHHHHHH CS
                  xxxxxxxxxxxx..............................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Lipase_GDSL   1 ivafGDSltdGd..............................................gaatlntiqlktpknlnefdlaldrianignkgasdnelq 52 
                  i ++GDS+t+ +                                              ++a  nt++ +       f      + +++++ a+d + +
   EFC37977.1 167 IEFIGDSITCAYgnmgkppcaytpatqnvhesfvektaryvnaseihiecwsgkgvvrNFADKNTTSVDP------F------PVYYPRTLANDANSV 252
                  679*******888787777777777555544444444444444444444433222222222222222222......2......334444444444444 PP

                  CCHECTTTECHHHHHCTTSEEEEE--CTCC-EECSSCTTTCEEHHHHHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Lipase_GDSL  53 qllnkyplkseqlkalhpdlviislGtNDsnlgkkstdaakkeaeeyiknlreaik 108
                           +   k + pd+ +i lGtND+        a   + e++ + ++++++
   EFC37977.1 253 WEF------R---KTFIPDIAVITLGTNDF------STAPRPSFEQFSNGYQKFLD 293
                  444......3...7789*************......44555555555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       550  (0.0306766); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2041.01
//
Query:       EFC37978.1  [L=156]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.7e-10   38.5   0.0    1.4e-09   37.6   0.0    1.4  1  Biotin_lipoyl  Biotin-requiring enzyme


Domain annotation for each model (and alignments):
>> Biotin_lipoyl  Biotin-requiring enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   0.0     8e-14   1.4e-09       3      71 ..      21      90 ..      19      92 .. 0.96

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 8e-14
                   EEESSSEEEEEE..ECSESSSTTCEE-TTSEEEEEECTTEEEEEEBSSSEEEEEESSTTTEEE-TTCEEE CS
  Biotin_lipoyl  3 iksPmiGesveeg.vvevlvkvGdkVkagqvlaeveamKmemeieapkaGvvkeilvkeGdtvevgdlla 71
                   i++P +Ge + +  +++++++ Gd V  g+ l+e+ a  ++++i a+ +G+ ke l  eG+  +vgd++ 
     EFC37978.1 21 ITVPRVGEGISTLqITKWHKQIGDLVDYGDALVEMKASQLSIDIYAERRGIMKEHLMREGEYAHVGDVVS 90
                   89*********99******************************************************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1005  (0.0560544); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1046.15
//
Query:       EFC37979.1  [L=164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-46  156.5   0.0    4.1e-46  156.1   0.0    1.1  1  UQ_con         Ubiquitin-conjugating enzyme
     0.0019   17.9   0.0     0.0029   17.3   0.0    1.3  1  Prok-E2_B      Prokaryotic E2 family B
     0.0053   16.6   0.3       0.01   15.7   0.3    1.4  1  UEV            UEV domain
     0.0065   16.7   0.9      0.016   15.5   0.7    1.8  1  RWD            RWD domain
  ------ inclusion threshold ------
      0.087   11.3   0.7      0.095   11.2   0.7    1.1  1  Cytomega_UL84  Cytomegalovirus UL84 protein


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  156.1   0.0   1.1e-49   4.1e-46       1     139 [.       5     141 ..       5     142 .. 0.98

  Alignments for each domain:
  == domain 1  score: 156.1 bits;  conditional E-value: 1.1e-49
                 HHHHHHHHHHHSTTTTEEEEEEETTEECEEEEEEEB.TTSTTTTEEEEEEEE--TTTTTS--EEEESST-SCTTBETTSBB-CGGGSTTT--TTSHHHH CS
      UQ_con   1 rlqkelkelakkkpsgisaklvddenlfewkvlikgpedtpYeggvFklelefpedYPlkpPkvkfvtkifHPnvdksGevcldiLkeekWspaltles 99 
                 r++k+l++l++ + +g++a+++ d ++f+w++ i gp dtpYe+gvFk++++fp+dYP+++P+++fvt+i+HPnv+++G+vcl+iL ++ W+p++++++
  EFC37979.1   5 RVMKDLTTLQQVPIEGLTAGPIGD-DVFSWNGYIDGPVDTPYEDGVFKVKITFPTDYPFTAPRLSFVTPIYHPNVNSDGKVCLSILDKD-WNPSVNISQ 101
                 799********************8.**************************************************************55.********* PP

                 HHHHHHHHHHS--TTS-SSHHHHHHHHHTHHHHHHHHHHH CS
      UQ_con 100 vllsiqsLlaepnpesplnkeaakllkkdreeykkkvkey 139
                 vl+++q Ll+epnpes++  +++k++++dre+++k+++++
  EFC37979.1 102 VLMTVQLLLKEPNPESAVLPSIGKQYEDDREAFNKEARKH 141
                 ************************************9875 PP

>> Prok-E2_B  Prokaryotic E2 family B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   8.2e-07    0.0029      35     114 ..      47     131 ..      37     160 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 8.2e-07
   Prok-E2_B  35 ggtvdlrlvypdsfpllppavflqdpeqlkllpHintfggaLClleeeldldewdpngsvadvleqlqqvLn.egisgde...........d 114
                  g++++++ +p ++p+  p+ + + p      p +n+ +g +Cl         w+p  ++ +vl  +q +L+  ++++              
  EFC37979.1  47 DGVFKVKITFPTDYPFTAPRLSFVTPI---YHPNVNS-DGKVCLS---ILDKDWNPSVNISQVLMTVQLLLKePNPESAVlpsigkqyeddR 131
                 68999**********************...67999**.******5...555679******************88888776666744444433 PP

>> UEV  UEV domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.3   2.8e-06      0.01      50     113 ..      50     111 ..      36     119 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2.8e-06
                 EEEEEE--TTTTTS--EE.EE-GCC--TSGGGGGB-TTSBB--HHHH.S--T..TT--HHHHHHHHHH CS
         UEV  50 iPiliwvlesyPveaPiv.yvkptksmvikknenvdaqGlvylpyLe.eWkr..eksnlvslvqelaq 113
                 + + i  + +yP++aP + +v+p        + nv+++G+v l +L+ +W++  + s++++ vq l +
  EFC37979.1  50 FKVKITFPTDYPFTAPRLsFVTPIY------HPNVNSDGKVCLSILDkDWNPsvNISQVLMTVQLLLK 111
                 457788899****999762555543......469************7258884444556666665544 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.7   4.3e-06     0.016      54      97 ..      49      94 ..      35     158 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 4.3e-06
                EEEEEEEE-SSTTSS--EEEEEECC...SS-HHHHHHHHHHHHHHHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxx RF
         RWD 54 slkleiklpeeYPeeaPiislsste...nlpkeqvksleekleelae 97
                 +k++i++p +YP +aP +s+ ++    n+ +++ k + + l++ ++
  EFC37979.1 49 VFKVKITFPTDYPFTAPRLSFVTPIyhpNV-NSDGKVCLSILDKDWN 94
                689*****************9999844411.4444444445555444 PP

>> Cytomega_UL84  Cytomegalovirus UL84 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.7   2.6e-05     0.095     124     180 ..      99     159 ..      63     164 .] 0.61

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.6e-05
  Cytomega_UL84 124 pfqillstplqlgeangesqtapatsq.eeet..aashepekkk.ekeekkeeededdrnd 180
                      q+l++  l l e n es   p+  +  e+   a  +e  k+  e+ +kk ee++ +  +
     EFC37979.1  99 ISQVLMTVQLLLKEPNPESAVLPSIGKqYEDDreAFNKEARKHTqEHAKKKTEEENKEETQ 159
                    5699*******************97641343311333333333212222333333322222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2367  (0.132021); expected 358.6 (0.02)
Passed bias filter:                      979  (0.0546043); expected 358.6 (0.02)
Passed Vit filter:                       109  (0.00607954); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 1091.03
//
Query:       EFC37980.1  [L=441]
Description: beta-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.6e-49  166.8   0.4    1.4e-48  165.8   0.2    1.6  2  Tubulin          Tubulin/FtsZ family, GTPase domain
    1.9e-20   73.3   0.3    3.3e-20   72.5   0.3    1.4  1  Tubulin_C        Tubulin C-terminal domain
    6.5e-05   23.2   0.0    0.00012   22.3   0.0    1.5  1  Misat_Tub_SegII  Misato Segment II tubulin-like domain
    0.00018   21.3   0.0    0.00034   20.4   0.0    1.5  1  Tubulin_3        Tubulin domain
  ------ inclusion threshold ------
       0.22   11.9   0.0       0.66   10.4   0.0    1.7  2  DUF3842          Domain of unknown function (DUF3842)


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  165.8   0.2   3.8e-52   1.4e-48       1     197 []       3     212 ..       3     212 .. 0.94
   2 ?   -2.5   0.0       1.4     5e+03      55      88 ..     277     307 ..     264     334 .. 0.64

  Alignments for each domain:
  == domain 1  score: 165.8 bits;  conditional E-value: 3.8e-52
                 EEEEEEEHHHHHHHHHHHHH...HHHCH..............HHHT.....TTEEEEE....EEESBHHHHHTS-GS......EEEE--CCCCTTC--T CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiqsdg..........dslesfFsesgkveyiprsvaidtdpqvlneikagselfnpnklllgkegagnngag 89 
                 ei+ + +G+cGn+ign++w+ +++eh+i++++          ++  ++F ++++++++pr v++d+++++++++ ++++l++++   ++  g gn++++
  EFC37980.1   3 EIVSLFIGGCGNRIGNCFWKGIMREHNIDTNTgeriegfedvEENLNIFLDEREDKFVPRVVMADLEAETIESMIKNENLLESKFASFQRCGNGNCFSR 101
                 7999************************94446*********666666666777***********************9********************* PP

                 T-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--...GG.G-HHHHHHHHHHHHHHHHT-SEEE CS
     Tubulin  90 gypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs...efsevvvepynailalkelieesdavi 185
                 g ++ g+ +++ i+++ rk+ve+cd ++gf++++s+ GG+GSGlg++++++l+ee+p++++ t  vlPs   +  +  ++ yna l+++ l+e+ d+v+
  EFC37980.1 102 GMYTDGALLIRNIMDQARKSVEQCDFFEGFQMFHSIIGGSGSGLGSLVVSKLREEFPDKMMATATVLPSnkdDYGSRSLSHYNAGLSMHYLVENTDFVT 200
                 *********************************************************************755555677899****************** PP

                 EEEHHHHHCCST CS
     Tubulin 186 vidNdaLlkiln 197
                 +++N+aL +i+n
  EFC37980.1 201 CLNNEALGNICN 212
                 **********97 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.4
                 ESBHHHHHTS-GS......EEEE--CCCCTTC-- CS
     Tubulin  55 dtdpqvlneikagselfnpnklllgkegagnnga 88 
                 dt+p+ ++ ++++  +fn+++ll++ + + + ++
  EFC37980.1 277 DTEPT-VEGLTSD--VFNQTNLLISMDPSLGRYM 307
                 56554.4555555..8999999988876666555 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.5   0.3   9.2e-24   3.3e-20       1     125 [.     261     381 ..     261     382 .. 0.93

  Alignments for each domain:
  == domain 1  score: 72.5 bits;  conditional E-value: 9.2e-24
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEE.SSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEE.CE CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirG.dvepkevnkavqrikekkkaqfveWiptgikvalnk.ks 97 
                 PrlhF+++s +P++  ++    + +v+ +t+++++++n+++++dp+ g+y++ ++++r  + +++ +++ v++ k+ ++a f eW+p++i+++++k  s
  EFC37980.1 261 PRLHFFTVSHSPFCLGDT----EPTVEGLTSDVFNQTNLLISMDPSLGRYMTNIITYRDnEPNISMIEEYVRKFKKDNEAIFKEWVPNNIHTSVCKsIS 355
                 9*************9865....679******************************99984678999****************************97258 PP

                 CT-TTTSSCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C  98 pyvkkqskvsvlmlaNttsiaelfkrll 125
                 p   ++s  s++m++Nt++i+++f++++
  EFC37980.1 356 PDCPTKS--SATMVSNTSAIKTVFNKIS 381
                 8888888..****************986 PP

>> Misat_Tub_SegII  Misato Segment II tubulin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.0   3.5e-08   0.00012       1      81 [.       2      85 ..       2     107 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 3.5e-08
  Misat_Tub_SegII  1 rEivtlqlGnyaNyvgtHfWN..tQesyftydeeeee...sevdhdvlfregetkqgqvtytPRllivDlk.gslgslrkegelyee 81
                     rEiv+l +G   N +g  fW   ++e++++++  e     ++v+++++ +    ++++ +++PR+++ Dl+ ++++s+ k+++l e+
       EFC37980.1  2 REIVSLFIGGCGNRIGNCFWKgiMREHNIDTNTGERIegfEDVEENLNIFL---DEREDKFVPRVVMADLEaETIESMIKNENLLES 85
                     8*******************8668999997777777556677777776666...677899*********972567899999998885 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   9.4e-08   0.00034      33     150 ..      83     200 ..      73     241 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 9.4e-08
   Tubulin_3  33 lnskllpfedwsvGeeLfeeldkehdlldrdl....rpfaeecdqlrglqvftgvddaWG.GfaakylerlrdeygkksilvWvlaleeklkkkkkakl 126
                 l+sk  +f++   G+ + + +  +  ll r++    r+ +e+cd ++g+q+f ++    G G ++  + +lr+e++ k + +    +  +++  k    
  EFC37980.1  83 LESKFASFQRCGNGNCFSRGMYTDGALLIRNImdqaRKSVEQCDFFEGFQMFHSIIGGSGsGLGSLVVSKLREEFPDKMMATA---TVLPSN--KDDYG 176
                 566666666666666666666666666666543333999*************9987655549***************986333...223332..23334 PP

   Tubulin_3 127 erklkklnkarslkelseqaslyv 150
                 +r+l++ n   s++ l e++  ++
  EFC37980.1 177 SRSLSHYNAGLSMHYLVENTDFVT 200
                 567888888888888877766555 PP

>> DUF3842  Domain of unknown function (DUF3842)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   0.00018      0.66       4      31 ..     137     164 ..     136     171 .. 0.87
   2 ?   -3.9   0.0       4.9   1.7e+04      88     123 ..     363     398 ..     360     403 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00018
     DUF3842   4 viDgqGggiGkelveklkkelpeeveil 31 
                 +i g G+g+G+ +v+kl++e+p+++  +
  EFC37980.1 137 IIGGSGSGLGSLVVSKLREEFPDKMMAT 164
                 899*******************996544 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 4.9
     DUF3842  88 maeavaeseakkillpvnkenveivgveeeplkeli 123
                  a+ v++++a k +    +++++++  ++  l++++
  EFC37980.1 363 SATMVSNTSAIKTVFNKISDQFTVMFRRRAFLHQYL 398
                 567777777877777776777777666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       527  (0.0293937); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.24s 00:00:00.83 Elapsed: 00:00:00.44
# Mc/sec: 2997.42
//
Query:       EFC37981.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       722  (0.04027); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 2313.69
//
Query:       EFC37982.1  [L=119]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.8e-05   24.7   0.1    5.1e-05   23.9   0.1    1.4  1  Hemerythrin  Hemerythrin HHE cation binding domain


Domain annotation for each model (and alignments):
>> Hemerythrin  Hemerythrin HHE cation binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.1   2.9e-09   5.1e-05       5     124 ..      21     112 ..      18     118 .. 0.77

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 2.9e-09
                  HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH.CCC.HHHHHHHHHHHHHHHHHHHHHHHHCHTCGGSTC CS
  Hemerythrin   5 aldeeHralrallerlraladaaaevhgalrklaelldelvdeleaHhaaEEellfPlledrpggravldvlereHdeirelleelrellkgleepsa 102
                   l e+H++l+ l+++l    da        r + ++l+el d++  H++ EE+l+           ++ +++++ Hd + + + +l  + +g      
   EFC37982.1  21 ELNEQHKKLFTLINAL----DA-------KRSCGTTLKELLDYVVFHFKTEEDLF-AKAG-----WSESASHKETHDKFVQDALALTSVGDG------ 95 
                  6889**********55....45.......57799********************5.4444.....688889*****9999877666654444...... PP

                  HHHHHHHHHHHHHHHHHHHHHH CS
  Hemerythrin 103 aafaelleeladllreHiakEe 124
                       +++ + ++l  Hi+  +
   EFC37982.1  96 -----EMQFIKQWLITHICASD 112
                  .....35777777777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       500  (0.0278878); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 797.19
//
Query:       EFC37983.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.8e-62  210.0   9.8    6.2e-62  209.6   9.8    1.1  1  HSP70            Hsp70 protein
    8.8e-12   44.5   0.2    5.3e-10   38.6   0.1    2.9  2  MreB_Mbl         MreB/Mbl protein
     0.0001   22.7   0.1     0.0097   16.3   0.0    3.0  2  FtsA             Cell division protein FtsA
     0.0017   17.6   1.1     0.0093   15.2   0.0    2.7  2  StbA             StbA protein
  ------ inclusion threshold ------
       0.03   14.3   0.5      0.087   12.8   0.1    2.0  2  Methyltransf_32  Methyltransferase domain


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  209.6   9.8   1.7e-65   6.2e-62       2     518 ..       7     553 ..       6     584 .. 0.81

  Alignments for each domain:
  == domain 1  score: 209.6 bits;  conditional E-value: 1.7e-65
                 EEEEEXSSEEEEEEEET...TEEEEEXXTTSXSSEESEEEEXTTSEE..ETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHH.HTTXSSEEEEETT CS
       HSP70   2 iGiDLGttnsvvavmeg...gkievianeegnrttPsvvaFtkkerl..vGeaAkrqavtnpkntvfsvKrliGrkfsdpevqke.ikelpykvvkken 94 
                 +GiD Gttn+  ++ e+   ++++ i+   g+    s +a +kk+++  vG +  + +       +++ KrliGr+++  + +++ ++ l y+v +  +
  EFC37983.1   7 VGIDYGTTNTKASIREEyicNQPKCIEFVSGKNYLSSEIAINKKDKSciVGLEDGESTY----YKIAESKRLIGRAYKSVMNKEDfSTRLGYHVANV-D 100
                 8*************99755579*********************9775226765554444....457899********98665555267899**9998.5 PP

                 SBEEEEE..EETTE......EEEHHHHHHHHHHHHHHH...HHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCS CS
       HSP70  95 gkavvev..eaage......kftpeqisamvLkklket...aeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkk 182
                 g a +++  ++ g       +  p+ ++a +Lkk+k++   +++y ++++ +av+tvPa +  +q+ at++A+++ GL+vl ++ epTAaala+   kk
  EFC37983.1 101 GMANIRInsTTDGSndveiiDIDPRLVTADILKKVKKHiidTNNYPDDTIVQAVVTVPANYGYSQKSATMEAAELSGLQVLLLIPEPTAAALAFLDSKK 199
                 6555555005555578888999**************97555789999***********************************************55555 PP

                 SSCEEEEEEEEXSSXEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHH..........HHHHHHHHHHHTTTSS CS
       HSP70 183 dkernvlvyDlGggtfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqr..........lkeaaekaKkeLSssk 271
                  ++   lv+D+Gggt d S+++le  ++ vk   g+  lGG d+D+a++e l +++    +i ++ ++   +           lk++ + +K  LS+ +
  EFC37983.1 200 FSDGYYLVIDFGGGTLDLSLVHLEGKKVIVKKVFGNMFLGGGDVDQAIAEVLKTKIDPALEIPVQIENIFSKTteivnfnnaiLKKKSKTLKEMLSEGT 298
                 59*****************************************************99887775543322111111111122338999999********* PP

                 CSEEEEEEEEEETTT.EEEEEEEEHHHHHHHHHHHHHHTHHHHHHHHHHCTEE.GGGCSEEEEESGGGGSHHHHHHHHHHTTCHHBSSSHTT..THHHH CS
       HSP70 272 qteinleietvdedg.kdlseklsRakfeelvedllertlepvekalkdaklk.keeidevvlvGGstRiPkvqelvkelfgkepsktvnpD..eavai 366
                 ++ei+l+i+    +g k ++ ++s++   el++ l ++  ep+ek+lk+ k   + e+d ++l GGs+++P++++  +++f++   +t   D    va+
  EFC37983.1 299 NEEISLSINLKGYSGmKIVNLSFSKQ---ELCAVLNSKFREPFEKVLKECKNGmECELDGILLAGGSSKLPTIESWTRNVFEQVTIHTHAHDvqTLVAR 394
                 **********9999977888888875...7899999**************998456**************************98877776663368*** PP

                 HHHHHHH.HHCTCGCSHCC.EEEEBESS-EEEEETTTEEEEEESTTCBSS......EEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECE CS
       HSP70 367 GAAvqag.vlsgeeevkdl.lllDvtpLslgietlggvmtkliernttip......tkksqvfstaadnqtaveievlqgerelvkdnkllgsfeldgi 457
                 GA + a+ + +g+++ ++l +++ vt+  lgiet+  v+t   e  t ip      t+ +++f+ + d q++ +i+vl+   e  +d ++++s  ++ +
  EFC37983.1 395 GAFLAAEsIRNGTNQLENLqVMEEVTATHLGIETKN-VVTDKVEFTTLIPmhsplkTSFTKTFTNVVDDQEKAKIRVLENLSESFEDSTEISSLVINIM 492
                 ***99955999******9945789*********985.555555556666511111044458999999**************************988755 PP

                 SSCSTTCSEEEEEEEEETTSCEEEEEEETTTCCEEEEEEECCSS..SBHHHHHHHHHHHHHCH CS
       HSP70 458 ppaprGvpqieVtfdidanGiltvsakdketgkeeeitieaseg..lseeeiekmvkdaeesa 518
                    ++G+ +i+Vtf++d nGil+v+  +++ + +++ +i+++ +   + e+ie+  k ++  +
  EFC37983.1 493 -KRKKGETKIDVTFSVDLNGILQVAIVEQGRDSDNKHEIKTTLTnlWTPEQIEEFRKRKHF-S 553
                 .59**********************999977666666655544433899999998776543.3 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0     0.062   2.2e+02       4      28 ..       7      30 ..       5      55 .. 0.79
   2 !   38.6   0.1   1.5e-13   5.3e-10      73     323 ..     127     404 ..     115     408 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.062
                EEEEE-SSEEEEEETTTEEEEEEES CS
    MreB_Mbl  4 lgiDLGtantlvyvkgkgivlneps 28
                +giD Gt+nt + ++++ i  n+p 
  EFC37983.1  7 VGIDYGTTNTKASIREEYI-CNQPK 30
                79**********9999876.45555 PP

  == domain 2  score: 38.6 bits;  conditional E-value: 1.5e-13
                 HHHHHHHHHHHHHHTSS-SS--EE...EEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--TTS.SS-.EEEEEE-SS-EEEEEEETTE CS
    MreB_Mbl  73 vaeellkyfikkvkkkkslskprv...vicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglpvee.psg.nmvvdiGggttevavislgg 166
                 v++++lk++ k++ ++++++ +++   v++vP +    ++ A +eaa+  G +  lli ep aAA+   l+ ++ + g  +v+d Gggt +++++ l g
  EFC37983.1 127 VTADILKKVKKHIIDTNNYPDDTIvqaVVTVPANYGYSQKSATMEAAELSGLQVLLLIPEPTAAALA-FLDSKKfSDGyYLVIDFGGGTLDLSLVHLEG 224
                 678889999999888888876655222799************************************5.4555551344369***************987 PP

                 ...EEEEE..EES-SHHHHHHHHHHHHHHHHS..EE--.......HHHHHHHHHHH-BSS--HHHH.EEEEEEEETTTTCEEEEE.......EEHHHHH CS
    MreB_Mbl 167 ...ivtsk..svrvaGdeldeaiikyirkkyn..lliG.......ertaekikieigsavkeeeee.kmeikGrdlvtglpkeve.......vsseevr 243
                    iv++    + ++G ++d+ai + +++k +  l i+       ++t+e +  + + ++k++++  +m  +G++    l  +++       v+ +  +
  EFC37983.1 225 kkvIVKKVfgNMFLGGGDVDQAIAEVLKTKIDpaLEIPvqienifSKTTEIVNFNNAILKKKSKTLkEMLSEGTNEEISLSINLKgysgmkiVNLSFSK 323
                 54233322224579**************99753355551111111456666666666555555544578888887665555444311110002222222 PP

                 HHHHHHHH.HHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHH.SS-EEE.-SSTTTHHHHHHHHTTC-HH CS
    MreB_Mbl 244 ealkepvs.aiveavkevLektppeLaadivdrgivltGGgallkgldkllseet.glpvkv.aedpltcvakGtgkvleklk 323
                 + l  +++ +  e  ++vL++++  +  ++   gi+l+GG+++l  ++++ ++ + ++ +++ a+d  t va+G+  ++e+++
  EFC37983.1 324 QELCAVLNsKFREPFEKVLKECKNGMECEL--DGILLAGGSSKLPTIESWTRNVFeQVTIHThAHDVQTLVARGAFLAAESIR 404
                 233333321334456777888887776665..7****************999887346665437889999****998888776 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.036   1.3e+02       1      38 [.       7      46 ..       7      85 .. 0.86
   2 !   16.3   0.0   2.7e-06    0.0097       2      88 ..     207     378 ..     206     481 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.036
                EEEEE-SSSEEEEEEETTEEEEEEEES-..-HHHHHHHHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxx RF
        FtsA  1 alvDiGagktdvavaedgalvhlrvigv..ggngitkdia 38
                +++D G++ t++++ e+    + + i +  g n ++++ia
  EFC37983.1  7 VGIDYGTTNTKASIREEYICNQPKCIEFvsGKNYLSSEIA 46
                68************99966666888888766677777766 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 2.7e-06
                 EEEE-SSSEEEEEEETTE..EEEEEEES-...-HHHHHHHHHHHHT--HHHHHHHHHHH--S--...................EEEEEHHHHH...... CS
                 xxxxxxxxxxxxxxxxxx..xxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...................xxxxxxxxxx...... RF
        FtsA   2 lvDiGagktdvavaedga..lvhlrvigv...ggngitkdiakalrtaveeAerikikyGsala...................ekeigrkels...... 70 
                 ++D+G+g+ d+++++ ++  ++  +v g    gg  +++ ia++l+t ++ A +i +++ + ++                            +      
  EFC37983.1 207 VIDFGGGTLDLSLVHLEGkkVIVKKVFGNmflGGGDVDQAIAEVLKTKIDPALEIPVQIENIFSktteivnfnnailkkksktL--------Kemlseg 297
                 8**********999886533333444444778************************7655555566666666666666554440........1444466 PP

                 ...............................................................GGGGSTTHHHHHHHHHT- CS
                 ...............................................................xxxxxxxxxxxxxxxxxx RF
        FtsA  71 ...............................................................ggsalpnleelaeralsp 88 
                                                                                g+s+lp +e   ++++++
  EFC37983.1 298 tneeislsinlkgysgmkivnlsfskqelcavlnskfrepfekvlkeckngmeceldgillagGSSKLPTIESWTRNVFEQ 378
                 666666777788888888888889999999999999999999999999999999999999999777777777777776632 PP

>> StbA  StbA protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   2.6e-06    0.0093     145     212 ..     184     254 ..     163     285 .. 0.81
   2 ?   -1.4   0.1      0.29   1.1e+03     136     176 ..     390     430 ..     361     496 .. 0.60

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.6e-06
        StbA 145 lPeslPagfealke.ldeleslLiiDlGGttLDvakv..rgklegiskvkgdskiGvslitdavkealeta 212
                 +Pe   a+   l++   +    L+iD+GG tLD++ v  +gk   + kv+g+  +G   + +a+ e+l+t+
  EFC37983.1 184 IPEPTAAALAFLDSkKFSDGYYLVIDFGGGTLDLSLVhlEGKKVIVKKVFGNMFLGGGDVDQAIAEVLKTK 254
                 5777777666665523344568***********9976226899999********************99875 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.29
        StbA 136 sftikkvkvlPeslPagfealkeldeleslLiiDlGGttLD 176
                 + + +      es+  g++ l++l+ +e +    lG  t +
  EFC37983.1 390 TLVARGAFLAAESIRNGTNQLENLQVMEEVTATHLGIETKN 430
                 33344444445555555555555555555555555554444 PP

>> Methyltransf_32  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   2.4e-05     0.087      25      90 ..      27      91 ..      15     122 .. 0.84
   2 ?   -4.2   0.0       4.2   1.5e+04      26      40 ..     204     218 ..     197     226 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.4e-05
  Methyltransf_32 25 galtvvDvGaGkgYLsfvlalkekeyklkvvgidakeelvekaekraeklgkkfnkrlsfaelsie 90
                     ++ + +++ +Gk YLs+ +a  +k+ k  +vg++  e+   k+ + ++ +g+++++ +++++ s++
       EFC37983.1 27 NQPKCIEFVSGKNYLSSEIAI-NKKDKSCIVGLEDGESTYYKIAESKRLIGRAYKSVMNKEDFSTR 91
                     566789999************.566699**************************999998887654 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 4.2
  Methyltransf_32  26 altvvDvGaGkgYLs 40 
                         v+D+G G   Ls
       EFC37983.1 204 YYLVIDFGGGTLDLS 218
                      56799***9975555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       922  (0.0514251); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 3669.77
//
Query:       EFC37984.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.4e-22   77.1  20.1    6.5e-06   26.8   0.1    7.1  7  WD40         WD domain, G-beta repeat
    4.8e-07   30.0   0.0        3.9    7.8   0.0    5.2  5  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    3.1e-05   24.0   0.0       0.38   10.6   0.0    3.2  3  eIF2A        Eukaryotic translation initiation factor eIF2A


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   0.6     0.004        24      12      37 ..       4      29 ..       2      30 .. 0.85
   2 !    5.7   0.1    0.0052        31      15      29 ..      49      63 ..      46      70 .. 0.87
   3 !   10.2   0.0   0.00019       1.1       5      38 .]      87     120 ..      83     120 .. 0.71
   4 !   11.6   0.3   6.8e-05      0.41       4      38 .]     127     163 ..     124     163 .. 0.74
   5 !   26.8   0.1   1.1e-09   6.5e-06       2      38 .]     168     206 ..     167     206 .. 0.95
   6 !   10.3   0.0   0.00018       1.1       4      38 .]     213     249 ..     210     249 .. 0.76
   7 !   15.9   0.0   2.9e-06     0.017      14      37 ..     267     290 ..     250     290 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.004
                SEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40 12 svtslafspdgawlasGsdDgtvriW 37
                s++++++s+d+++++s  + g++ +W
  EFC37984.1  4 SIYGISWSRDSSLVVSVARGGNLAFW 29
                699***********987778888777 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0052
                EEEEETTSSEEEEEE CS
        WD40 15 slafspdgawlasGs 29
                +++ sp+g+++a+G+
  EFC37984.1 49 CCSLSPSGRLIATGG 63
                8889**********8 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00019
                 EEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 r  +GH +  +s+ f ++ ++++s++ Dg + +Wd
  EFC37984.1  87 RNMSGHrGYLSSCEFIDEIQLVTSSG-DGYCILWD 120
                 55679976677774444446677777.*******9 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 6.8e-05
                 EEEEESS.SSEEEEE.EETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtsla.fspdgawlasGsdDgtvriWd 38 
                 ++ ++ H s+  s++ ++ d ++++sGs D +v +Wd
  EFC37984.1 127 VHYFKKHkSDCMSVSvNPIDRNLFISGSCDMKVCLWD 163
                 6778899777778884444555567**99*******9 PP

  == domain 5  score: 26.8 bits;  conditional E-value: 1.1e-09
                 EEEEEEESS.SS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ss.vtslafspdgawlasGsdDgtvriWd 38 
                 +c+ +++GH s+ +++++f p+g  +++Gs+D t++++d
  EFC37984.1 168 KCVNSFKGHhSHdINAVKFFPNGLGFVTGSEDLTCKLFD 206
                 89*******9778************************98 PP

  == domain 6  score: 10.3 bits;  conditional E-value: 0.00018
                 EEEEESS..SS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGH..ss.vtslafspdgawlasGsdDgtvriWd 38 
                 l+t++    +  ++s++fs++g+ l++++  +++  Wd
  EFC37984.1 213 LTTFSNDelNEpISSVCFSKSGRILFASH-GPSIIAWD 249
                 555553334225**************988.99999998 PP

  == domain 7  score: 15.9 bits;  conditional E-value: 2.9e-06
                 EEEEEETTSSEEEEEETTSEEEEE CS
        WD40  14 tslafspdgawlasGsdDgtvriW 37 
                 ++l +spdg+ la+Gs+D+ +ri+
  EFC37984.1 267 SCLEVSPDGSALAAGSWDHFLRIF 290
                 6999******************96 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.017        99      38      76 ..       2      40 ..       1      84 [. 0.75
   2 !    7.8   0.0   0.00066       3.9      52      86 ..     106     137 ..     101     145 .. 0.84
   3 !    5.9   0.0    0.0025        15      13      75 ..     153     215 ..     145     219 .. 0.78
   4 !    5.0   0.0     0.005        30      31      62 ..     215     246 ..     209     265 .. 0.82
   5 ?    1.3   0.0      0.07   4.2e+02      38      64 ..     263     289 ..     247     291 .] 0.80

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.017
  ANAPC4_WD40 38 dsevrsLaWkpdgklLavaysdgevrlldaesgkvvhsl 76
                 ds++ +++W+ d +l + +   g++ +    + k + ++
   EFC37984.1  2 DSSIYGISWSRDSSLVVSVARGGNLAFWRTRENKKIAEM 40
                 567888888888888888877778777766555554444 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00066
  ANAPC4_WD40  52 lLavaysdgevrlldaesgkvvhslsvksekavtc 86 
                   L+ +  dg + l d+e g+ vh ++ ++++   c
   EFC37984.1 106 QLVTSSGDGYCILWDVEMGRAVHYFKKHKSD---C 137
                  5888999******************999886...3 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0025
  ANAPC4_WD40  13 atedgellvfRlngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhs 75 
                  +++d+++ +  l +++ ++  + ++++ ++++++ p+g  ++ + +d +++l+d   ++ + +
   EFC37984.1 153 GSCDMKVCLWDLRMKKCVNSFKGHHSHDINAVKFFPNGLGFVTGSEDLTCKLFDLRVERPLTT 215
                  566777777777777777777888999999999999999999999999999999877766665 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.005
  ANAPC4_WD40  31 tleedkedsevrsLaWkpdgklLavaysdgev 62 
                  t+++d+ ++ ++s++++++g++L  ++  + +
   EFC37984.1 215 TFSNDELNEPISSVCFSKSGRILFASHGPSII 246
                  45789999***************998876554 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.07
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrl 64 
                  + + ++L+ +pdg+ La +  d  +r+
   EFC37984.1 263 NIKCSCLEVSPDGSALAAGSWDHFLRI 289
                  556779999*********998887777 PP

>> eIF2A  Eukaryotic translation initiation factor eIF2A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.0   6.3e-05      0.38     125     170 ..      24      71 ..       4      75 .. 0.78
   2 !    5.9   0.0    0.0018        10      75     113 ..     149     191 ..     130     197 .. 0.72
   3 !    5.0   0.0    0.0033        20      62     156 ..     181     276 ..     178     285 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 6.3e-05
                 -EEEEEETTTTEEEEEEE-..TT--EEEE-TTSSEEEEEE-TTT-SSS CS
       eIF2A 125 Geleiwdvkkkkkiakaea..anatlvewspdgryvlTattaprlrvd 170
                 G+l++w + + kkia++    +++  +  sp+gr+++T  t   + vd
  EFC37984.1  24 GNLAFWRTRENKKIAEMMVldYWTMCCSLSPSGRLIATGGTRNDVYVD 71 
                 889***********9987522789**************9987766666 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0018
                 EEEESSSSCEEEEEECS....CEEEEEEEEES--EEEE-TTSS CS
       eIF2A  75 aviyGkmpakvslfdlk....vkviskleeqkrNtiffspkgk 113
                 + i G  ++kv l+dl+    v+  +  +++  N+++f p+g 
  EFC37984.1 149 LFISGSCDMKVCLWDLRmkkcVNSFKGHHSHDINAVKFFPNGL 191
                 45899999*******9854444555556677889999999885 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0033
                 EEEEEE-TTSS-EEEEESSSSCEEEEEECSCE.EEEEEEEES--....EEEE-TTSSEEEEE-TTSSS-EEEEEETT..TTEEEEEEE-TT--EEEE-T CS
       eIF2A  62 ihdvaWspkskefaviyGkmpakvslfdlkvk.viskleeqkrN....tiffspkgklvllaGfgnlaGeleiwdvk..kkkkiakaeaanatlvewsp 153
                 i +v+  p++  f  + G  + + +lfdl+v+ +++++++++ N    ++ fs++g+++ +a  g     +  wd+   k+++     + +++ +e sp
  EFC37984.1 181 INAVKFFPNGLGF--VTGSEDLTCKLFDLRVErPLTTFSNDELNepisSVCFSKSGRIL-FASHGPS---IIAWDTLtgKMNCEIAKLNIKCSCLEVSP 273
                 5566666666544..79************965278899999888444459999999965.4555543...56677764433333333345667777777 PP

                 TSS CS
       eIF2A 154 dgr 156
                 dg+
  EFC37984.1 274 DGS 276
                 776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       337  (0.0187964); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1681.87
//
Query:       EFC37985.1  [L=773]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-07   30.8  13.2    4.3e-07   29.9  13.2    1.4  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.9  13.2   2.4e-11   4.3e-07       2      38 ..      92     127 ..      91     129 .. 0.93

  Alignments for each domain:
  == domain 1  score: 29.9 bits;  conditional E-value: 2.4e-11
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysessk 38 
                 aC++Crk ++KCd+  P C+ C+k +++C+ y+ +++
  EFC37985.1  92 ACTSCRKLHRKCDKTLPCCAYCVKTGKQCV-YPSPRR 127
                 9*****************************.887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (773 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1714  (0.0955993); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.83u 0.33s 00:00:01.15 Elapsed: 00:00:00.52
# Mc/sec: 4492.03
//
Query:       EFC37986.1  [L=576]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-07   31.6  11.2    2.6e-07   30.6  11.2    1.5  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6  11.2   1.5e-11   2.6e-07       2      39 ..      64     100 ..      63     101 .. 0.90

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 1.5e-11
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 aC +Crk + KCd+k   Cs+C+  +++C+ y+ ++kr
  EFC37986.1  64 ACARCRKLHKKCDKKLTGCSKCANAGVDCV-YKTPQKR 100
                 9*************7666************.8887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       782  (0.0436165); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 3490.02
//
Query:       EFC37987.1  [L=430]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.014   15.0   1.8       0.03   13.9   1.8    1.5  1  DUF5052   Domain of unknown function (DUF5052)
       0.12   12.5   3.5       0.53   10.5   3.5    2.1  1  FYVE      FYVE zinc finger
       0.38   10.9   6.5        3.9    7.7   0.0    4.1  4  NHL       NHL repeat
       0.79   10.2   4.7       0.37   11.2   0.6    2.3  2  BRCT_2    BRCT domain, a BRCA1 C-terminus domain
        2.1    9.2  12.6        2.1    9.2   0.9    3.0  3  Ntox50    Bacterial toxin 50


Domain annotation for each model (and alignments):
>> DUF5052  Domain of unknown function (DUF5052)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   1.8   8.4e-06      0.03      24     102 ..     291     376 ..     280     400 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 8.4e-06
     DUF5052  24 skindikgklvgneltistYDeegnkilevkgkkisitsnketsskdsegevkee........SsvitvtvdgkeiesvGdtlifae 102
                 ++ + +++++ gn++ ++tYD+    + + + + i + sn+   + +++g++ ++        S+ i+++  g+++  +Gd+ i   
  EFC37987.1 291 KVSSTLRENINGNNMFVDTYDNICGVTTNHENNLI-VVSNRYIITCNKKGKIFSKvekvssgaSKRIHLDPSGEHMYFIGDSGIEST 376
                 5667899***************9988777776655.556777888888888776666788889999***************998766 PP

>> FYVE  FYVE zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   3.5   0.00015      0.53       4      59 ..      95     224 ..      92     231 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00015
                 -...--SB-TTT--B-.-SSS--EE-TTT--EE-STTS-EEE.EE...................................................... CS
        FYVE   4 kddsevkkCeiCakkF.sllrrrhhCrlCGkvvCekCssklvall...................................................... 47 
                 k++ evk C++C k   + ++  h+C  C   +Ce++ + + ++                                                       
  EFC37987.1  95 KPKVEVKYCDKCLKDEeEKVQATHYCSGCSMNYCEAHINLHNSANktkghaesgqvsslaaahvplallpdlqqicvlpnpdspfsctidhgygslfvl 193
                 677899******99886888**************99987666555445555555555555555555555555555555555555555555555555555 PP

                 ...................GGGTEEEEEEE- CS
        FYVE  48 ...................ekeaeeksvrvC 59 
                                     + +e++ vrvC
  EFC37987.1 194 dgdmfmeydlttkelvnhfREPQERRAVRVC 224
                 5555555555555555555555556666666 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.2     0.045   1.6e+02       6      22 ..     222     240 ..     218     246 .. 0.64
   2 ?   -3.5   0.1       3.8   1.4e+04      12      17 ..     282     287 ..     278     292 .. 0.59
   3 ?    1.4   0.1       0.1   3.7e+02       6      20 ..     315     330 ..     315     337 .. 0.82
   4 ?    7.7   0.0    0.0011       3.9       6      28 .]     406     429 ..     405     429 .. 0.93

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.045
                 EEEEETTTE..EEEEECCC CS
         NHL   6 GvavdsnGd..iyVaDsen 22 
                  v++dsn+d  iyV D++ 
  EFC37987.1 222 RVCYDSNDDtlIYVLDRCA 240
                 6777755543499999554 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 3.8
                 TTEEEE CS
         NHL  12 nGdiyV 17 
                 +G ++V
  EFC37987.1 282 DGIVCV 287
                 566665 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.1
                 EEEEE.TTTEEEEEEC CS
         NHL   6 Gvavd.snGdiyVaDs 20 
                 Gv+ +  n+ i+V+++
  EFC37987.1 315 GVTTNhENNLIVVSNR 330
                 7888989999999885 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.0011
                 EEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   6 Gvavd.snGdiyVaDsenhrvqvF 28 
                 + a+d ++G++yV + + + vqvF
  EFC37987.1 406 DMAIDfTSGEVYVVNPHKSKVQVF 429
                 679999*****************9 PP

>> BRCT_2  BRCT domain, a BRCA1 C-terminus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.3      0.46   1.7e+03      54      75 ..      83     109 ..      51     115 .. 0.70
   2 ?   11.2   0.6    0.0001      0.37      32      79 ..     289     342 ..     272     348 .. 0.64

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.46
      BRCT_2  54 e.....laekrkrrvvspkyIkdCikk 75 
                 +     ++ + k++ v +ky + C+k 
  EFC37987.1  83 TikssnKKPRVKKPKVEVKYCDKCLKD 109
                 032333455778888999999999986 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.0001
      BRCT_2  32 GGevvetitsavyiviaesneee....................laekrkrrvvspkyIkdCikkgkll 79 
                 +G+v++t                                    +++++++ vvs +yI  C kkgk+ 
  EFC37987.1 289 DGKVSSTL--------------ReningnnmfvdtydnicgvtTNHENNLIVVSNRYIITCNKKGKIF 342
                 23333333..............02222334445555555678888999*****************985 PP

>> Ntox50  Bacterial toxin 50
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   2.2    0.0058        21       2      71 ..      38     107 ..      37     121 .. 0.80
   2 ?    9.2   0.9   0.00057       2.1      39      88 ..     288     339 ..     283     341 .. 0.90
   3 ?   -2.5   0.0       2.6   9.4e+03      46      75 ..     388     417 ..     375     425 .. 0.71

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0058
      Ntox50   2 negkqgkHikghknYeegkSyllidskeaqellkkyagtgevvkdrkgkwrnkevvdfgevigvvvdket 71 
                 negk + H ++++ ++e+ S+  +++k++ +   +   + + +k   +  ++k +v+ ++v  ++ dk  
  EFC37987.1  38 NEGKRNPHAPSDNDFDENDSSNNNNNKKPSSSSSNRLDNSSSSKATIKSSNKKPRVKKPKVEVKYCDKCL 107
                 799*****************99999999999888888888777777888888888888888888877543 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00057
      Ntox50  39 gtgevvkd.rkgkwrnkevvdf.gevigvvvdketgeeteTklgkIhyskkg 88 
                 ++g+v+++ r+  ++n+ +vd+ ++++gv  ++e++  +  ++ +I   kkg
  EFC37987.1 288 KDGKVSSTlRENINGNNMFVDTyDNICGVTTNHENNLIVVSNRYIITCNKKG 339
                 578899998899999*****9889********************99999998 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.6
      Ntox50  46 drkgkwrnkevvdfgevigvvvdketgeet 75 
                 ++k  +++k  v  ge i + +d ++ge++
  EFC37987.1 388 NDKVDYDHKFEVSRGEGIDMAIDFTSGEVY 417
                 357778888888888888888887777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (430 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1366  (0.0761894); expected 358.6 (0.02)
Passed bias filter:                      487  (0.0271627); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.44
# Mc/sec: 2938.17
//
Query:       EFC37988.1  [L=426]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (426 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       970  (0.0541023); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 2580.17
//
Query:       EFC37989.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.055   12.6   3.9      0.067   12.3   3.9    1.1  1  SAP130_C   Histone deacetylase complex subunit SAP130 C-termi
        1.5    9.4  19.8        1.1    9.9   1.0    3.8  3  zf-CCCH_2  RNA-binding, Nab2-type zinc finger


Domain annotation for each model (and alignments):
>> SAP130_C  Histone deacetylase complex subunit SAP130 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   3.9   7.4e-06     0.067      91     147 ..      26      78 ..       4     104 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 7.4e-06
    SAP130_C  91 tsqhpaqaiptllaaaappsqpsavlsalpaavavtppvpaslanvvasptqpaass 147
                  s +++  +++ ++++ p+ qps+  ++++a+ ++++   +s +n+ a++tqpa++ 
  EFC37989.1  26 MSSNNSMMVSSGITTSNPTPQPSS--TSITASTSIATQ--TSTSNTPATSTQPATTH 78 
                 3445677899999*********98..789999999888..6789999******9886 PP

>> zf-CCCH_2  RNA-binding, Nab2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.3    0.0043        39       1      10 [.      86      95 ..      86      97 .. 0.87
   2 ?    9.9   1.0   0.00012       1.1       1      10 [.     108     117 ..     108     119 .. 0.92
   3 ?    7.3   1.5   0.00075       6.7       1      11 [.     130     140 ..     130     142 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0043
   zf-CCCH_2  1 pCrffpnCtn 10
                +C+++ +Ct 
  EFC37989.1 86 KCKDWDKCTQ 95
                5*******85 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00012
   zf-CCCH_2   1 pCrffpnCtn 10 
                 pCr++ +C+n
  EFC37989.1 108 PCRNGSHCKN 117
                 9*******99 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.00075
   zf-CCCH_2   1 pCrffpnCtnp 11 
                 pC+++  C+++
  EFC37989.1 130 PCKDGKQCKKK 140
                 9*******655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1427  (0.0795917); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 960.31
//
Query:       EFC37990.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      6e-09   36.4   0.0    2.2e-08   34.6   0.0    2.0  2  PolyA_pol  Poly A polymerase head domain
     0.0069   16.2  23.3       0.24   11.3   0.1    5.3  5  zf-CCCH_4  CCCH-type zinc finger
  ------ inclusion threshold ------
      0.023   14.7  21.7       0.71   10.0   0.2    5.2  4  zf_CCCH_4  Zinc finger domain
       0.04   13.9  28.5       0.72    9.9   0.3    5.3  5  zf-CCHH    PBZ domain
       0.75    9.8  21.0          9    6.3   0.6    5.3  5  zf-CCCH    Zinc finger C-x8-C-x5-C-x3-H type (and similar)


Domain annotation for each model (and alignments):
>> PolyA_pol  Poly A polymerase head domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.6   0.0   6.3e-12   2.2e-08       1     126 []     317     462 ..     317     462 .. 0.80
   2 ?   -2.6   0.0         2   7.2e+03      17      58 ..     467     509 ..     465     540 .. 0.59

  Alignments for each domain:
  == domain 1  score: 34.6 bits;  conditional E-value: 6.3e-12
                 EEEETHHHHHHHTT---C.............EEEEEECS-HHHHHHHHHHHHT-EEEEETTTTCCCCEECCEE...EEECCEE.CEEEEEE---SSHHH CS
   PolyA_pol   1 lylvGGaVRDlllgkepk.............DvDlatdaapeelakllrkkvkeallsgeefqtiavlekkql...levatfR.lekdesdarnpesek 82 
                 +++vGGaVRD++ +  ++             D+D+    +p+ ++  l +k+k  +      ++++v  ++ +   le   +  l++d ++++++  + 
  EFC37990.1 317 IFIVGGAVRDVIREVIVEkktnalqimnnikDIDIGFGCDPQTFHGRLTRKYKSGVPIPGPRGLVQVGSSNGSdlfLEGKAINgLNNDNKSVKAQIAQC 415
                 59********875443322344666777777**********************9888877778888888775557888665551566666677777788 PP

                 ...HHHHHHCTSSBGGGS-EEECTTTCEE-TTS...HHHHHHTTEE- CS
   PolyA_pol  83 stesleeDlkrRDftiNalaynlnkgkvlDlfg...GikdLkskvir 126
                 + ++l+   + RDft N+l y++ ++ ++D +g   Gikd+ sk +r
  EFC37990.1 416 YGTNLRGENICRDFTCNSLWYDPINKCIIDTIGngqGIKDVISKNLR 462
                 999****************************9887899999988876 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2
                 -CEEEEEECS-HHHHHHHHHHHHT-EEEE.ETTTTCCCCEECC CS
   PolyA_pol  17 pkDvDlatdaapeelakllrkkvkealls.geefqtiavlekk 58 
                 p D+ + ++++p++l +  +  +k++ +  + +  +i+  ++ 
  EFC37990.1 467 PRDWEFWVSGNPTKLMRFYKFLLKGYSADaKTKSFIIEQVKSG 509
                 5788888888888888777766666555544444444433333 PP

>> zf-CCCH_4  CCCH-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.1    0.0014       4.9      10      17 ..      30      37 ..      27      38 .. 0.89
   2 ?    2.4   1.6     0.039   1.4e+02      11      18 ..      49      56 ..      48      56 .. 0.94
   3 !   11.3   0.1   6.6e-05      0.24      10      20 ..      80      90 ..      79      90 .. 0.92
   4 !    5.5   3.9    0.0042        15      10      18 ..     120     128 ..     116     128 .. 0.93
   5 ?   -1.3   0.0      0.58   2.1e+03       2      10 ..     425     433 ..     424     433 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0014
   zf-CCCH_4 10 sCrfGdnC 17
                +C+fG+nC
  EFC37990.1 30 ICKFGPNC 37
                7******* PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.039
   zf-CCCH_4 11 CrfGdnCr 18
                Cr+G+ Cr
  EFC37990.1 49 CRYGEDCR 56
                *****998 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 6.6e-05
   zf-CCCH_4 10 sCrfGdnCrFs 20
                +C++G++C+++
  EFC37990.1 80 ICKWGEKCKYL 90
                5********96 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.0042
   zf-CCCH_4  10 sCrfGdnCr 18 
                 +C++G nCr
  EFC37990.1 120 KCKYGKNCR 128
                 7*******9 PP

  == domain 5  score: -1.3 bits;  conditional E-value: 0.58
   zf-CCCH_4   2 lCpyfakGs 10 
                 +C+ f+++s
  EFC37990.1 425 ICRDFTCNS 433
                 7**999875 PP

>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.4    0.0043        15       9      16 ..      31      38 ..      30      39 .. 0.91
   2 ?    4.8   1.5    0.0084        30       9      16 ..      49      56 ..      49      56 .. 0.97
   3 ?   10.0   0.2    0.0002      0.71       9      18 ..      81      90 ..      80      90 .. 0.92
   4 ?    5.7   1.6    0.0047        17       8      16 ..     120     128 ..     120     130 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0043
   zf_CCCH_4  9 CkkGdkCr 16
                Ck+G +C+
  EFC37990.1 31 CKFGPNCP 38
                *******8 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0084
   zf_CCCH_4  9 CkkGdkCr 16
                C++G+ Cr
  EFC37990.1 49 CRYGEDCR 56
                *******8 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.0002
   zf_CCCH_4  9 CkkGdkCrFa 18
                Ck+G+kC+++
  EFC37990.1 81 CKWGEKCKYL 90
                *********6 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.0047
   zf_CCCH_4   8 tCkkGdkCr 16 
                 +Ck+G +Cr
  EFC37990.1 120 KCKYGKNCR 128
                 6*******9 PP

>> zf-CCHH  PBZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.3     0.032   1.2e+02       4      10 ..      31      37 ..      29      37 .. 0.93
   2 ?    9.9   0.3    0.0002      0.72       3      12 ..      48      57 ..      46      59 .. 0.94
   3 ?    6.5   0.7    0.0023       8.2       4      24 ..      81     102 ..      79     104 .. 0.86
   4 ?    0.3   0.2       0.2   7.2e+02      13      23 ..     109     119 ..     109     120 .. 0.89
   5 ?    7.1   7.5    0.0015       5.3       1      24 [.     118     146 ..     118     148 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.032
     zf-CCHH  4 CkYGkkC 10
                Ck+G +C
  EFC37990.1 31 CKFGPNC 37
                ******* PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0002
     zf-CCHH  3 pCkYGkkCYR 12
                pC+YG+ C+R
  EFC37990.1 48 PCRYGEDCRR 57
                8********9 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0023
     zf-CCHH   4 CkYGkkC.YRkNpqHfqefsHP 24 
                 Ck+G+kC Y   ++H + f H+
  EFC37990.1  81 CKWGEKCkYLNDEEHVNMFLHT 102
                 *******888899999999886 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.2
     zf-CCHH  13 kNpqHfqefsH 23 
                 k + H++ f+H
  EFC37990.1 109 KDEVHKERFRH 119
                 5689******* PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.0015
     zf-CCHH   1 RPpCkYGkkCYRk.....NpqHfqefsHP 24 
                 R +CkYGk+C+       N +H  +f HP
  EFC37990.1 118 RHKCKYGKNCRSLdgkyeNWEHYVKFIHP 146
                 679*******9876777788888888887 PP

>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.2    0.0037        13      14      22 ..      30      38 ..      26      38 .. 0.84
   2 ?    6.3   0.6    0.0025         9      14      23 ..      48      57 ..      41      58 .. 0.90
   3 ?    3.6   0.1     0.018        66      14      23 ..      80      89 ..      78      90 .. 0.87
   4 ?    6.0   1.2    0.0031        11      13      22 ..     119     128 ..     116     130 .. 0.87
   5 ?   -2.4   0.1       1.4   5.1e+03      22      27 .]     142     147 ..     142     147 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0037
                --TTGGG-S CS
     zf-CCCH 14 yCkyGdrCk 22
                +Ck+G++C+
  EFC37990.1 30 ICKFGPNCP 38
                7*******5 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0025
                --TTGGG-SS CS
     zf-CCCH 14 yCkyGdrCkF 23
                 C+yG+ C++
  EFC37990.1 48 PCRYGEDCRR 57
                6*******97 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.018
                --TTGGG-SS CS
     zf-CCCH 14 yCkyGdrCkF 23
                +Ck G++Ck+
  EFC37990.1 80 ICKWGEKCKY 89
                7********9 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.0031
                 S--TTGGG-S CS
     zf-CCCH  13 GyCkyGdrCk 22 
                 + CkyG +C+
  EFC37990.1 119 HKCKYGKNCR 128
                 58*******8 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 1.4
                 SSBSCS CS
     zf-CCCH  22 kFaHgq 27 
                 kF+H++
  EFC37990.1 142 KFIHPR 147
                 8***95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       774  (0.0431703); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 3064.22
//
Query:       EFC37991.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-54  184.9   1.6    4.4e-54  184.0   1.6    1.4  1  p450      Cytochrome P450
  ------ inclusion threshold ------
      0.048   13.7   0.0       0.11   12.6   0.0    1.5  1  DUF840    Lagovirus protein of unknown function (DUF840)


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  184.0   1.6   4.9e-58   4.4e-54       1     450 [.      72     544 ..      72     557 .. 0.87

  Alignments for each domain:
  == domain 1  score: 184.0 bits;  conditional E-value: 4.9e-58
                 --SESEHHCCHCHHHHTT..TCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHH CS
        p450   1 Ppgptplplvgnllqlgr..keelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkk 97 
                 +pgp++lpl+gnll l +  k +   ++ +l+++yg+++rlk  + + v+ls+pe++ e+++k+  e+ ++++++  +++++      + +   e w++
  EFC37991.1  72 MPGPKRLPLIGNLLDLIKnvKSNAGPYFLSLSEQYGDLVRLKTFNNDLVILSNPELMGELYKKE--EKRSTIQSSRKYKLERGIPLAPIEMLYEEPWQE 168
                 5899*************99999999***************************************..6777778888888664444444445555***** PP

                 HHHHHHHHHTSH.....STT.THHHHHHHHHHHHHHHHHCCCCHCS..EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSH....HHHHHHHHHHHHHHH CS
        p450  98 lRrfltptltsf.....gkl.sleelveeeaedlveklrkkagess..elditellskaaldvigsilFgarfdlledek....lselvkaveelssll 184
                 +R++++ ++            +l++l  e++++l+++l+++++  +    d ++ +s++ +d+++ +++g+++    d+     + e+ ++v+  ++ l
  EFC37991.1 169 TRQLFNIAMKPEfqdqvV-IpQLTQLNGEMIRRLIKYLEPTQDPDKfrLTDSVNAISRYGFDAVMAVFLGVKMT---DDItktfPFEISDFVKYSVESL 263
                 ****99888877766544.459999999*****************999999********************965...2222345558899999998888 PP

                 HCHHHHCCCCCH.HHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHCSCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHH.HHHHHHHHHHHH CS
        p450 185 skssvqllllfp.llkylptkllrklkeavkklkdlldklieerretldsakksrrdfldalllakkekkgesklsdeelaatvle.llfaGvdTtsst 281
                 +    + ll++p l++y+ tk +++++   +k +++++ +++  + + +++      ++ +l++ +   k+  + + e l+++v++ +l a++d t + 
  EFC37991.1 264 DV-IIR-LLTKPsLYQYFKTKEYKRMEFTYEKSFEYANYVMNRFKVNPSEK----PRLYELLMERS---KN--EPNPEILVQSVMNsFLQAAIDITMTM 351
                 44.344.555555*****************************999998888....78999999997...33..36889999998874778********* PP

                 HHHHHHHHHHSHHHHHHHHHHHHHHCCTTT..........T-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHH CS
        p450 282 lswaLyeLaknPevqeklreEidevlgdkr..........eptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyal 370
                 +s ++y La++P++q+kl++E+ ev+g+             +  ++++kl++++++++E+LRl p+ + +  R + +d++++gy+ipkGt+vi      
  EFC37991.1 352 MSHVMYRLAHHPDYQKKLYNELLEVFGEPTldevtsenglVVNAEQFKKLKLTKNFVEEVLRLNPFGYASSARILNNDTELGGYNIPKGTTVIALQRRA 450
                 **************************9988999****************************************************************** PP

                 HT-TTTSSSTTS--GGGGB-TTSCTESSCTT--TTEEGG..............GS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSC CS
        p450 371 hrdpevfpnPeeFdpeRFldekgnskrksfaflPFGaGp..............RnCiGerlArmelklflatlLqnFevelqpetdpppileks 450
                   ++e+ p+++eF peR+++++    ++sf + PFG G+              R C+G r+A++el + +++++++F+++l +++ p+++ ++s
  EFC37991.1 451 CLSEEFVPRAQEFIPERYERNSPLAMKSSFVSSPFGVGVsflsiasinlrikaRKCPGSRIATLELCMSIVNTVRHFKLSLEEKEFPEMSTDRS 544
                 **99999****************888************555555555555555****************************8888888777765 PP

>> DUF840  Lagovirus protein of unknown function (DUF840)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.2e-05      0.11      25      75 ..     380     430 ..     368     442 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.2e-05
      DUF840  25 lqlqkqamenglvlkadqlgrlgfnpnevknvivgnsfssnvrlsnmhnda 75 
                   l+  + englv++a+q+ +l +  n v +v+  n f        + nd+
  EFC37991.1 380 PTLDEVTSENGLVVNAEQFKKLKLTKNFVEEVLRLNPFGYASSARILNNDT 430
                 56777889*************************999986554444444554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       552  (0.0307881); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.36s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 3214.19
//
Query:       EFC37992.1  [L=415]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-23   81.9   7.1    8.5e-23   81.0   7.1    1.4  1  Rhomboid  Rhomboid family
  ------ inclusion threshold ------
      0.087   13.0   0.0       0.22   11.7   0.0    1.6  1  Ycf66_N   Ycf66 protein N-terminus


Domain annotation for each model (and alignments):
>> Rhomboid  Rhomboid family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.0   7.1   9.4e-27   8.5e-23       4     142 ..     181     330 ..     178     337 .. 0.93

  Alignments for each domain:
  == domain 1  score: 81.0 bits;  conditional E-value: 9.4e-27
                 CC-TTHHHHGGG--SSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH-S......-EESSHHHHHHHHHHHHHHHHCCCCGS-- CS
    Rhomboid   4 rgelwrlltsmflHagwlHllfNmlallvfGsplerrlGslrflllyllsglagsllsllfsaeses...plvGaSGaifgllgallvlvprnrkllrk 99 
                 ++++++llts+f+H++wlHl+f m+ l+ +Gs + + +G + fll+yl +g+++s++s+l++  ++     +vG SG if+++ a l  + +++ ++  
  EFC37992.1 181 KRRYHTLLTSTFVHGDWLHLGFCMYGLYNMGSLTYDLMGPTTFLLFYLGAGMTASMGSSLLKLITKNyyqRSVGSSGSIFAIVFAGLNVITFEKAKMNL 279
                 678999***********************************************999998887666556669***************************9 PP

                 --HC...........CCCCCCCCCCHHHCTSSSTTTHHHHHHHHHHHHHHH CS
    Rhomboid 100 liia........llllllfillnlvlgllpraggvsnlAHlgGllaGlllg 142
                 ++++          +l l+++ ++++ +++r+ + +  +Hl+G+laG+l+ 
  EFC37992.1 280 IFLPdswggfnaTYFLPLYFVGEILYNIFSRRVKLDTGGHLSGALAGYLAL 330
                 99999******999999******************************9975 PP

>> Ycf66_N  Ycf66 protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   2.4e-05      0.22      26      52 ..     136     162 ..     130     167 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.4e-05
     Ycf66_N  26 rdeDiffsgvgLlygliLlfqawrldg 52 
                 r++ ++++++gL ++++L++++++ ++
  EFC37992.1 136 RRYPVIWGIIGLNCAMMLMVKGFKRSP 162
                 78889*****************99877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (415 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       792  (0.0441742); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2562.23
//
Query:       EFC37993.1  [L=115]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.9e-09   36.7   0.1    3.1e-09   36.6   0.1    1.1  1  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
      0.031   13.6   0.0      0.047   13.0   0.0    1.2  1  Pkinase_Tyr  Protein tyrosine kinase
       0.06   12.9   0.0       0.07   12.7   0.0    1.1  1  RIO1         RIO1 family
       0.17   12.2   0.0       0.24   11.7   0.0    1.2  1  BAMBI        BMP and activin membrane-bound inhibitor (BAMBI)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6   0.1     7e-13   3.1e-09     118     188 ..      33     114 ..      11     115 .] 0.92

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 7e-13
                 TEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS............BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHH CS
     Pkinase 118 giiHrDlKpeNiLidekgelKitDFGlakelesssk............ltsfvgtseYlAPEvlkeneyskkvDvWslGvily 188
                 + iH D+Kp+N+    +g++ ++D+G++  ++s +              +s+  t+ Y +PE  k+  +s+k+D++slGv ++
  EFC37993.1  33 KTIHNDIKPDNVVKY-DGHFFLIDYGISLLYHSFNGnqcfdkelkpikSKSVLTTPLYDSPEKAKDGCVSPKSDLYSLGVYFF 114
                 679********9877.*************9999777889********9999****************************9875 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0     1e-05     0.047     123     195 ..      33     113 ..      26     114 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1e-05
                  TEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEE.........EETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHH CS
  Pkinase_Tyr 123 klvHrdlaarNvLlsenkvvkisDfGLardiekddey.........vkkeeaklpvkWmapEslkekkftsksDvWsfGvll 195
                  k +H d+   Nv+ + + +  + D+G++   ++ +            k+++  +   + +pE  k++ ++ ksD +s Gv  
   EFC37993.1  33 KTIHNDIKPDNVV-KYDGHFFLIDYGISLLYHSFNGNqcfdkelkpIKSKSVLTTPLYDSPEKAKDGCVSPKSDLYSLGVYF 113
                  7899999999985.556666777999987764433331122222233334444444577*********************86 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.6e-05      0.07     106     166 ..      15      73 ..       2      81 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.6e-05
                 HHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETTEEEE--GTTEEETTSTTHHHHHHH CS
        RIO1 106 eaeelyeevleemrklykeaglvHaDLSeyNvlvdedkvviIDvsQaveldhpnalefLer 166
                 + ee+  ++++   +l+  ++ +H D+   Nv+ +++++++ID + ++  +  n  + +++
  EFC37993.1  15 NKEEAIIDLVQ--LVLLGICKTIHNDIKPDNVVKYDGHFFLIDYGISLLYHSFNGNQCFDK 73 
                 34444455555..467789************************987776666666666655 PP

>> BAMBI  BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   5.4e-05      0.24      46      82 ..      68     104 ..      59     111 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.4e-05
       BAMBI  46 nacftrvldpqntnsplthgcldsllnsadvcssksv 82 
                 n cf + l p +++s lt   +ds  ++ d c s ++
  EFC37993.1  68 NQCFDKELKPIKSKSVLTTPLYDSPEKAKDGCVSPKS 104
                 89****************************9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (115 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       281  (0.0156729); expected 358.6 (0.02)
Passed bias filter:                      244  (0.0136092); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.42
# Mc/sec: 822.93
//
Query:       EFC37994.1  [L=605]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-56  189.2  15.6    8.3e-34  116.2   1.2    3.1  3  PEMT      Phospholipid methyltransferase
  ------ inclusion threshold ------
       0.25   11.8   4.1          3    8.3   0.6    3.3  2  ICMT      Isoprenylcysteine carboxyl methyltransferase (ICMT)


Domain annotation for each model (and alignments):
>> PEMT  Phospholipid methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.0   2.9   8.1e-27   7.3e-23       4     103 ..     204     303 ..     201     305 .. 0.97
   2 ?   -3.2   0.1       1.3   1.1e+04      66      73 ..     344     351 ..     327     368 .. 0.41
   3 !  116.2   1.2   9.3e-38   8.3e-34       2     105 ..     456     562 ..     455     563 .. 0.96

  Alignments for each domain:
  == domain 1  score: 81.0 bits;  conditional E-value: 8.1e-27
        PEMT   4 ilGlllialglllvlssiealgefgtfygdfFlelmdklvtsGiYrylnnPeyvgstlgflGlaLitgsaaglllallvllvylialkfvEephlakiY 102
                  +G+ l++++l+    +++ lg+  ++ gdfF+ l+++lv +Gi++++ +P+y  ++  ++G+++++ s ++l+++++++++ li+l fvE+ph++kiY
  EFC37994.1 204 GIGISLCLFNLWAKSDAHRVLGDYAWYWGDFFFLLDKNLVFDGIFQMFPHPMYSVGYSFYYGVSIMSRSHTVLVVSFCAHMLQLIFLVFVENPHIEKIY 302
                 57************************************************************************************************* PP

        PEMT 103 g 103
                 g
  EFC37994.1 303 G 303
                 8 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.3
        PEMT  66 laLitgsa 73 
                 ++L  ++ 
  EFC37994.1 344 TSLTASFT 351
                 22222222 PP

  == domain 3  score: 116.2 bits;  conditional E-value: 9.3e-38
        PEMT   2 rlilGlllialglllvlssiealgefgtfygdfFlelmd...klvtsGiYrylnnPeyvgstlgflGlaLitgsaaglllallvllvylialkfvEeph 97 
                 +l++G++li+l+++ ++s++e lg++g+fygdfF+ +++   +++++GiYrylnnPe v+++++++GlaLi++s+a+l la+l+++++++++kfvE+ph
  EFC37994.1 456 QLVAGIILILLNIYQSTSTHEVLGDHGWFYGDFFYTETNqnkQPSYTGIYRYLNNPEIVLGYCAYFGLALISKSYAVLGLAILSQFATYLFVKFVEKPH 554
                 6899*******************************7776799********************************************************* PP

        PEMT  98 lakiYgkr 105
                 ++kiYg++
  EFC37994.1 555 MDKIYGAK 562
                 ******86 PP

>> ICMT  Isoprenylcysteine carboxyl methyltransferase (ICMT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.6   0.00034         3      30      75 ..     237     280 ..     208     297 .. 0.68
   2 ?    2.7   0.2      0.02   1.8e+02      30      69 ..     494     532 ..     463     552 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00034
        ICMT  30 lpdhklvksglykylrHPnYllfvilelatllLlcnakltalvlla 75 
                 l d +lv +g+++++ HP Y +       +++++ + + t lv+++
  EFC37994.1 237 LLDKNLVFDGIFQMFPHPMYSVGYSF-YYGVSIMSRSH-TVLVVSF 280
                 55889***************984333.33344444442.3333332 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.02
        ICMT  30 lpdhklvksglykylrHPnYllfvilelatllLlcnaklt 69 
                 +++ +   +g+y+yl  P  +l  + +  +l+L+ + + +
  EFC37994.1 494 NQNKQPSYTGIYRYLNNPEIVL-GYCAYFGLALISKSYAV 532
                 566777789*********8777.66666666666666433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (605 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       728  (0.0406046); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.45
# Mc/sec: 4071.61
//
Query:       EFC37995.1  [L=514]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.8e-17   62.6   0.1    2.1e-07   31.1   0.0    3.2  3  F5_F8_type_C  F5/8 type C domain


Domain annotation for each model (and alignments):
>> F5_F8_type_C  F5/8 type C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0   0.00021       3.7      20     121 ..      90     194 ..      72     200 .. 0.70
   2 !   19.9   0.1   3.5e-08   0.00063      21     107 ..     265     346 ..     246     351 .. 0.77
   3 !   31.1   0.0   1.2e-11   2.1e-07      31     114 ..     418     499 ..     399     507 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00021
                   SSTTSSEE...ESSSSTTEEEEEEEEEEE....EEEEEEEEECSSTT..SSEEEEEEEEEESSSSSEEEEEEECE..EESSSSSSSEEEEEEEEEEE CS
  F5_F8_type_C  20 GnkntaWs...ssssddkqwlqvdLgkpk....kidgvvtqgrqdgg..nayvksykiqvsddgetWttvkdekv..pgnsdnstpvtntfdppvka 105
                   G+ + ++s   ++++++ + +qv + + +    +i++ ++ +    +   +y    +i++++  ++W+ +   k   +      ++  +t ++p+  
    EFC37995.1  90 GDAKEGFSgvcTTDATNREFIQVSFSSDHsmvaQITRMIIRPCIKDTwgPQYLDGCSIEYKSGQSDWQFLCKIKLdsK------GVMDITSPQPIPI 180
                   5555555543344555558888888665422227889999998776679******************99888333334......556699999**** PP

                   EEEEEEEEEEESSSSS CS
  F5_F8_type_C 106 ryvrltptswnggngi 121
                     +r+tp +++++  i
    EFC37995.1 181 STLRITPSTTSNY--I 194
                   *******994444..4 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 3.5e-08
                   STTSSEEESSSSTTEEEEEEEEEEEEEEEEEEEECSSTT..SSEEEEEEEEEESSSSSEEEEEEECEEESSSSSSSEEEEEEEEEEEEE CS
  F5_F8_type_C  21 nkntaWsssssddkqwlqvdLgkpkkidgvvtqgrqdgg..nayvksykiqvsddgetWttvkdekvpgnsdnstpvtntfdppvkary 107
                   n++t+ ++ ++ d +++q +L++p+ i+++ +++  ++g    y  +  +q+s+dg +W++v      ++++    ++ t++ p+k  y
    EFC37995.1 265 NDKTGAATFQELD-PYIQANLKSPQYITHLLVKPYAASGwgFKYLDNAWVQYSNDGIEWENVIK---ITDAN---RHVYTLPFPIKSAY 346
                   4455555555555.9*******************99888899999999**************99...55555...45556665666555 PP

  == domain 3  score: 31.1 bits;  conditional E-value: 1.2e-11
                   SSTTEEEEEEEEEEEEEEEEEEEECSSTT..SSEEEEEEEEEESSSSSEEEEEEECEEESSSSSSSEEEEEEEEEEEEEEEEEEEE CS
  F5_F8_type_C  31 sddkqwlqvdLgkpkkidgvvtqgrqdgg..nayvksykiqvsddgetWttvkdekvpgnsdnstpvtntfdppvkaryvrltpts 114
                   + ++++l   + + ++i+ +++   +dg+  + y  + kiq+s++g +W ++++    +++++++ + +  +pp+ ar+v+l+  +
    EFC37995.1 418 KGSSHYLLATFDQLYDIKLIKIRSLRDGSwgASYSEKIKIQYSENGVEWYDFRS----ADFNHEDLKFIYANPPICARFVKLVQNE 499
                   334499999*************999999999***********************....7888899****************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       473  (0.0263818); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 3151.02
//
Query:       EFC37996.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.1e-35  116.8   0.4     0.0052   16.7   0.0    8.6  9  LRR_6       Leucine Rich repeat
    1.2e-24   85.8   0.1    8.2e-08   31.9   0.1    3.4  3  LRR_8       Leucine rich repeat
    2.9e-22   78.4   2.5    0.00053   20.3   0.0    5.6  6  LRR_4       Leucine Rich repeats (2 copies)
    3.7e-14   52.4   0.2       0.17   11.8   0.0    7.3  8  RHH_3       Ribbon-helix-helix domain
    4.2e-13   47.9   0.0         37    5.4   0.0    8.3  8  LRR_1       Leucine Rich Repeat
     0.0011   19.0   4.9         57    3.8   0.0    6.6  7  Spidroin_N  Major ampullate spidroin 1, spider silk protein 1
     0.0029   17.4   9.8        1.5    8.6   0.2    3.9  4  UPF0193     Uncharacterised protein family (UPF0193)
  ------ inclusion threshold ------
      0.011   16.1   5.1         17    5.8   0.1    4.7  4  DUF4368     Domain of unknown function (DUF4368)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0     7e-05      0.16       5      19 ..       4      18 ..       2      23 .. 0.90
   2 !   13.7   0.0   2.1e-05     0.048       5      24 .]      28      47 ..      25      47 .. 0.92
   3 !    9.9   0.0   0.00035      0.79       5      19 ..      52      66 ..      49      71 .. 0.88
   4 !   16.7   0.0   2.3e-06    0.0052       4      24 .]      75      95 ..      72      95 .. 0.90
   5 !    9.9   0.0   0.00035      0.79       5      19 ..     100     114 ..      97     119 .. 0.88
   6 !   16.4   0.0   3.1e-06    0.0069       4      23 ..     123     142 ..     120     143 .. 0.90
   7 !   11.4   0.0   0.00012      0.26       4      19 ..     147     162 ..     144     167 .. 0.88
   8 !   15.2   0.0     7e-06     0.016       4      24 .]     171     191 ..     168     191 .. 0.91
   9 ?   -1.4   0.0       1.5   3.5e+03       4      10 ..     195     201 ..     193     201 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7e-05
       LRR_6  5 LteLdLsgNdIgDeG 19
                Lt+L++ +N+Ig eG
  EFC37996.1  4 LTSLNIGYNEIGVEG 18
                9***********999 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2.1e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+ +N+Ig eGa+ ++
  EFC37996.1 28 LTSLDIYSNEIGVEGAKYIS 47
                9***************9885 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00035
       LRR_6  5 LteLdLsgNdIgDeG 19
                Lt+Ld+ +N+Ig eG
  EFC37996.1 52 LTSLDIHYNEIGVEG 66
                9***********999 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 2.3e-06
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                 Lt+Ld+ +N+Ig eGa+ ++
  EFC37996.1 75 QLTSLDIHSNQIGVEGAKYIS 95
                69***************9885 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00035
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt+Ld+ +N+Ig eG
  EFC37996.1 100 LTSLDIHYNEIGVEG 114
                 9***********999 PP

  == domain 6  score: 16.4 bits;  conditional E-value: 3.1e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+Ld+ +N+Ig eGa+ +
  EFC37996.1 123 QLTSLDIHSNQIGVEGAKFI 142
                 69***************987 PP

  == domain 7  score: 11.4 bits;  conditional E-value: 0.00012
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 +Lt+Ld+ +N+Ig eG
  EFC37996.1 147 SLTSLDIHYNEIGVEG 162
                 8************999 PP

  == domain 8  score: 15.2 bits;  conditional E-value: 7e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+Ld+ +N+Ig eGa+ ++
  EFC37996.1 171 SLTSLDIYSNEIGVEGAKYIS 191
                 8****************9885 PP

  == domain 9  score: -1.4 bits;  conditional E-value: 1.5
       LRR_6   4 hLteLdL 10 
                  Lt+Ld+
  EFC37996.1 195 QLTSLDM 201
                 5999996 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   0.0   8.2e-10   1.8e-06       2      61 .]       3      62 ..       2      62 .. 0.97
   2 !   31.9   0.1   3.7e-11   8.2e-08       2      61 .]      75     134 ..      74     134 .. 0.98
   3 !   22.6   0.0     3e-08   6.8e-05       2      56 ..     147     201 ..     146     201 .. 0.97

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 8.2e-10
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsL++  N + + + ++ + +++L++Ld+ +N++ +  ++ +s +++L+sLd+ +N +
  EFC37996.1  3 QLTSLNIGYNEIGVEGSKFISEMKQLTSLDIYSNEIGVEGAKYISEMKQLTSLDIHYNEI 62
                7*********************************************************87 PP

  == domain 2  score: 31.9 bits;  conditional E-value: 3.7e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+++N++ + + +  + +++L++Ld+ +N++ +   + +s +++L+sLd+ +N++
  EFC37996.1  75 QLTSLDIHSNQIGVEGAKYISEMKQLTSLDIHYNEIGVEGSKYISEMNQLTSLDIHSNQI 134
                 79********************************************************98 PP

  == domain 3  score: 22.6 bits;  conditional E-value: 3e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 +LtsLd++ N + + + +  + +++L++Ld+ +N++ +  ++ +s +++L+sLd+
  EFC37996.1 147 SLTSLDIHYNEIGVEGSKYISEMKSLTSLDIYSNEIGVEGAKYISEMNQLTSLDM 201
                 7****************************************************96 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0     3e-06    0.0066       1      35 [.       2      37 ..       2      43 .. 0.83
   2 !    6.4   0.0    0.0057        13      21      35 ..      48      61 ..      39      69 .. 0.78
   3 !   16.5   0.1   3.8e-06    0.0086       1      36 [.      50      86 ..      50      89 .. 0.82
   4 !   18.9   0.0   6.7e-07    0.0015       2      36 ..      75     110 ..      74     120 .. 0.83
   5 !   20.3   0.0   2.4e-07   0.00053       2      35 ..     123     157 ..     122     164 .. 0.83
   6 !   19.3   0.2     5e-07    0.0011       1      40 [.     146     200 ..     146     206 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 3e-06
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnl 35
                ++L++L+++ N +   ++ + + +++L++Ld+ +N  
  EFC37996.1  2 KQLTSLNIGYNEIGVEGSkFISeMKQLTSLDIYSN-E 37
                58************777786655*********777.3 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0057
                H-TT--EEE-.-S-- CS
       LRR_4 21 klpnLkeLdLsgNnl 35
                 +++L++Ld++ N  
  EFC37996.1 48 EMKQLTSLDIHYN-E 61
                3999999999777.4 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 3.8e-06
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++Ld++ N +   ++  ++ + +L++Ld+++N +i
  EFC37996.1 50 KQLTSLDIHYNEIGVEGSkyISEMNQLTSLDIHSN-QI 86
                58************777776445*********666.77 PP

  == domain 4  score: 18.9 bits;  conditional E-value: 6.7e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++Ld+++Nq+   +   ++ +++L++Ld++ N  i
  EFC37996.1  75 QLTSLDIHSNQIGVEGAkyISEMKQLTSLDIHYN-EI 110
                 69***********766676445*********777.44 PP

  == domain 5  score: 20.3 bits;  conditional E-value: 2.4e-07
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnl 35 
                 +L++Ld+++Nq+   +  + + +++L++Ld++ N  
  EFC37996.1 123 QLTSLDIHSNQIGVEGAkFISeMKSLTSLDIHYN-E 157
                 69***********766696655*********777.4 PP

  == domain 6  score: 19.3 bits;  conditional E-value: 5e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S.............-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN.............nlitdld 40 
                 ++L++Ld++ N +   ++  ++ +++L++Ld+ +N             n++t+ld
  EFC37996.1 146 KSLTSLDIHYNEIGVEGSkyISEMKSLTSLDIYSNeigvegakyisemNQLTSLD 200
                 68************777776445********988856666666666666666665 PP

>> RHH_3  Ribbon-helix-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.5   3.3e+03      16      34 ..       6      24 ..       2      25 .. 0.70
   2 !   11.8   0.0   7.8e-05      0.17      12      35 ..      26      49 ..      21      49 .. 0.92
   3 ?    3.6   0.0     0.028        63      12      35 ..      50      73 ..      48      73 .. 0.85
   4 !    8.6   0.0   0.00079       1.8      12      35 ..      74      97 ..      72      97 .. 0.92
   5 ?    3.6   0.0     0.028        63      12      35 ..      98     121 ..      96     121 .. 0.85
   6 ?    4.5   0.0     0.015        33      12      35 ..     122     145 ..     120     148 .. 0.90
   7 ?    2.2   0.0     0.077   1.7e+02      22      35 ..     156     169 ..     146     172 .. 0.82
   8 !    9.2   0.0    0.0005       1.1      14      35 ..     172     193 ..     169     193 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.5
       RHH_3 16 kLkaLSekTrIprSkllde 34
                +L+   ++++++ Sk + e
  EFC37996.1  6 SLNIGYNEIGVEGSKFISE 24
                5555557899999998877 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 7.8e-05
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+ +S++++++ +k++ e+
  EFC37996.1 26 KQLTSLDIYSNEIGVEGAKYISEM 49
                799******************886 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.028
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+   ++++++ Sk++ e+
  EFC37996.1 50 KQLTSLDIHYNEIGVEGSKYISEM 73
                57788888889**********886 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.00079
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+  S++++++ +k++ e+
  EFC37996.1 74 NQLTSLDIHSNQIGVEGAKYISEM 97
                799******************886 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.028
       RHH_3  12 elaekLkaLSekTrIprSklldeA 35 
                 +++++L+   ++++++ Sk++ e+
  EFC37996.1  98 KQLTSLDIHYNEIGVEGSKYISEM 121
                 57788888889**********886 PP

  == domain 6  score: 4.5 bits;  conditional E-value: 0.015
       RHH_3  12 elaekLkaLSekTrIprSklldeA 35 
                 +++++L+  S++++++ +k + e+
  EFC37996.1 122 NQLTSLDIHSNQIGVEGAKFISEM 145
                 799*************99988775 PP

  == domain 7  score: 2.2 bits;  conditional E-value: 0.077
       RHH_3  22 ekTrIprSklldeA 35 
                 ++++++ Sk++ e+
  EFC37996.1 156 NEIGVEGSKYISEM 169
                 799********886 PP

  == domain 8  score: 9.2 bits;  conditional E-value: 0.0005
       RHH_3  14 aekLkaLSekTrIprSklldeA 35 
                 +++L+ +S++++++ +k++ e+
  EFC37996.1 172 LTSLDIYSNEIGVEGAKYISEM 193
                 678****************886 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0     0.017        37       1      18 [.       3      20 ..       3      25 .. 0.77
   2 ?    4.0   0.0     0.049   1.1e+02       1      18 [.      27      44 ..      27      49 .. 0.77
   3 ?    4.6   0.0     0.031        69       1      20 [.      51      70 ..      51      73 .. 0.80
   4 ?    4.6   0.0     0.031        70       1      18 [.      75      92 ..      75      97 .. 0.77
   5 ?    4.6   0.0     0.031        69       1      20 [.      99     118 ..      99     121 .. 0.80
   6 ?    4.3   0.0     0.039        88       1      15 [.     123     137 ..     123     145 .. 0.76
   7 ?    4.9   0.0     0.025        56       1      20 [.     147     166 ..     147     169 .. 0.81
   8 ?    4.5   0.0     0.032        72       1      19 [.     171     189 ..     171     209 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.017
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++L++++n ++  ++ 
  EFC37996.1  3 QLTSLNIGYNEIGVEGSK 20
                599*******99666655 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.049
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++Ld+ +n ++  ++ 
  EFC37996.1 27 QLTSLDIYSNEIGVEGAK 44
                599*******98766655 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.031
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++Ld+ +n ++  ++ ++
  EFC37996.1 51 QLTSLDIHYNEIGVEGSKYI 70
                599*******9987777666 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.031
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++Ld+ +n+++  ++ 
  EFC37996.1 75 QLTSLDIHSNQIGVEGAK 92
                599*******99766655 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.031
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+ +n ++  ++ ++
  EFC37996.1  99 QLTSLDIHYNEIGVEGSKYI 118
                 599*******9987777666 PP

  == domain 6  score: 4.3 bits;  conditional E-value: 0.039
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++Ld+ +n+++  
  EFC37996.1 123 QLTSLDIHSNQIGVE 137
                 599******998655 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.025
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld+ +n ++  ++ ++
  EFC37996.1 147 SLTSLDIHYNEIGVEGSKYI 166
                 69********9987777666 PP

  == domain 8  score: 4.5 bits;  conditional E-value: 0.032
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++Ld+ +n ++  ++ +
  EFC37996.1 171 SLTSLDIYSNEIGVEGAKY 189
                 699*******986655554 PP

>> Spidroin_N  Major ampullate spidroin 1, spider silk protein 1, N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.025        57      99     117 ..      12      30 ..       8      37 .. 0.87
   2 ?    1.1   0.0      0.17   3.9e+02      98     117 ..      35      54 ..      31      61 .. 0.87
   3 ?    0.7   0.0      0.22     5e+02      99     118 ..      60      79 ..      56      85 .. 0.86
   4 ?    0.6   0.0      0.24   5.3e+02      99     117 ..      84     102 ..      79     105 .. 0.87
   5 ?    0.7   0.0      0.22     5e+02      99     118 ..     108     127 ..     104     133 .. 0.86
   6 ?    3.0   0.0     0.043        97      99     117 ..     132     150 ..     128     151 .. 0.87
   7 ?    2.3   0.0     0.073   1.6e+02     101     118 ..     158     175 ..     152     202 .. 0.62

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.025
                 HHTSS--HHHHHHHHHHHH CS
  Spidroin_N  99 qttGsvnkqfineiksLik 117
                 + +G++ ++fi+e+k+L +
  EFC37996.1  12 NEIGVEGSKFISEMKQLTS 30 
                 578*************976 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.17
                 HHHTSS--HHHHHHHHHHHH CS
  Spidroin_N  98 lqttGsvnkqfineiksLik 117
                  + +G++  ++i+e+k+L +
  EFC37996.1  35 SNEIGVEGAKYISEMKQLTS 54 
                 5679*************976 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.22
                 HHTSS--HHHHHHHHHHHHH CS
  Spidroin_N  99 qttGsvnkqfineiksLikm 118
                 + +G++ +++i+e+++L ++
  EFC37996.1  60 NEIGVEGSKYISEMNQLTSL 79 
                 6799************9765 PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.24
                 HHTSS--HHHHHHHHHHHH CS
  Spidroin_N  99 qttGsvnkqfineiksLik 117
                 + +G++  ++i+e+k+L +
  EFC37996.1  84 NQIGVEGAKYISEMKQLTS 102
                 5789************976 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.22
                 HHTSS--HHHHHHHHHHHHH CS
  Spidroin_N  99 qttGsvnkqfineiksLikm 118
                 + +G++ +++i+e+++L ++
  EFC37996.1 108 NEIGVEGSKYISEMNQLTSL 127
                 6799************9765 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.043
                 HHTSS--HHHHHHHHHHHH CS
  Spidroin_N  99 qttGsvnkqfineiksLik 117
                 + +G++  +fi+e+ksL +
  EFC37996.1 132 NQIGVEGAKFISEMKSLTS 150
                 578*************976 PP

  == domain 7  score: 2.3 bits;  conditional E-value: 0.073
                 TSS--HHHHHHHHHHHHH CS
  Spidroin_N 101 tGsvnkqfineiksLikm 118
                 +G++ +++i+e+ksL ++
  EFC37996.1 158 IGVEGSKYISEMKSLTSL 175
                 566666666666666443 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.2   0.00067       1.5     170     207 ..      17      54 ..      11      64 .. 0.91
   2 ?    3.9   0.2     0.018        41     171     207 ..      66     102 ..      59     109 .. 0.90
   3 ?    2.9   0.1     0.038        84     171     206 ..     114     149 ..     107     155 .. 0.89
   4 !    6.4   0.1    0.0031       6.9     170     206 ..     161     197 ..     154     201 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00067
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                 e  +F++eM++L   + Y+++I  e ++ + e+++l +
  EFC37996.1  17 EGSKFISEMKQLTSLDIYSNEIGVEGAKYISEMKQLTS 54 
                 5579******************************9975 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.018
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                   ++++eM++L   + +++ I  e ++ + e+++l +
  EFC37996.1  66 GSKYISEMNQLTSLDIHSNQIGVEGAKYISEMKQLTS 102
                 57899****************************9975 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.038
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklreleald 206
                   ++++eM++L   + +++ I  e ++ + e+++l 
  EFC37996.1 114 GSKYISEMNQLTSLDIHSNQIGVEGAKFISEMKSLT 149
                 57899***************************9986 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.0031
     UPF0193 170 eRkeFLeeMeaLGqgkkYraiIeteIsqklreleald 206
                 e  ++++eM++L   + Y+++I  e ++ + e+++l 
  EFC37996.1 161 EGSKYISEMKSLTSLDIYSNEIGVEGAKYISEMNQLT 197
                 55789****************************9986 PP

>> DUF4368  Domain of unknown function (DUF4368)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.1    0.0091        20      40      64 ..      38      63 ..      13      65 .. 0.83
   2 ?    5.8   0.1    0.0074        17      39      64 ..      85     111 ..      68     113 .. 0.81
   3 ?    3.7   0.0     0.035        80      48      64 ..     142     159 ..     116     161 .. 0.77
   4 ?   -3.4   0.0       5.7   1.3e+04      14      28 ..     188     202 ..     187     208 .. 0.62

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0091
     DUF4368 40 IeVheaekkdgkrt.qeieIyYnfvG 64
                I V  a+++++ ++  + +I+Yn +G
  EFC37996.1 38 IGVEGAKYISEMKQlTSLDIHYNEIG 63
                66777778666666699********9 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0074
     DUF4368  39 kIeVheaekkdgkrt.qeieIyYnfvG 64 
                  I V  a+++++ ++  + +I+Yn +G
  EFC37996.1  85 QIGVEGAKYISEMKQlTSLDIHYNEIG 111
                 57777788877776669*********9 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.035
     DUF4368  48 kdgkrt.qeieIyYnfvG 64 
                 +++ ++  + +I+Yn +G
  EFC37996.1 142 ISEMKSlTSLDIHYNEIG 159
                 5555556899*******9 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 5.7
     DUF4368  14 kFlalvrkytdieeL 28 
                 k+++ +++ t+++ L
  EFC37996.1 188 KYISEMNQLTSLDML 202
                 566666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       144  (0.00803168); expected 358.6 (0.02)
Passed bias filter:                       81  (0.00451782); expected 358.6 (0.02)
Passed Vit filter:                         8  (0.000446204); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 1397.67
//
Query:       EFC37997.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00012   21.8   0.1    0.00029   20.6   0.0    1.7  2  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.059   13.5   2.1          5    7.2   0.5    2.8  2  DUF2315     Apoptogenic protein 1


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   3.3e-08   0.00029       2      47 ..      98     146 ..      97     147 .. 0.88
   2 ?   -2.9   0.0      0.75   6.7e+03      38      47 ..     244     253 ..     241     254 .. 0.73

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 3.3e-08
  F-box-like   2 srLPdE.iLlqIFsyLppsdLlrla..lVCrrWrrvaldtplLWrrlvl 47 
                  +LP+E +   I  ++++++ l+++  lVCr+W++   d+ ++W++l++
  EFC37997.1  98 KSLPPEiVAYSIVPFMDLESVLNGSvfLVCRSWYEGMIDEERMWQELFC 146
                 68****4456799999*******9999********999999****9987 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.75
  F-box-like  38 tplLWrrlvl 47 
                  p+L++r  +
  EFC37997.1 244 APSLYSRFHI 253
                 469**99876 PP

>> DUF2315  Apoptogenic protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.5   0.00056         5      71      97 ..      13      39 ..       2      47 .. 0.72
   2 ?    4.5   0.0    0.0038        34      58     109 ..     351     402 ..     339     409 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00056
     DUF2315 71 ekkeelsaeemseFYkeFldknakkhl 97
                + k++ + +  s+FY++Fl++++k+  
  EFC37997.1 13 SMKNSYKRNLKSAFYEKFLQEEQKRIE 39
                25667777888***********99865 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0038
     DUF2315  58 eeflesllkekglekkeelsaeemseFYkeFldknakkhlaYnaeWykrnlk 109
                 e+  es+++e++ + ++  s  ++s+F k+++ k+  k ++  ++W  + ++
  EFC37997.1 351 ENDEESEQDETDGNAQKGSSNRAISTFKKKWIGKDFVKIHDDGQSWLFKFIS 402
                 2333333333333577888999*************99999999999777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1612  (0.0899102); expected 358.6 (0.02)
Passed bias filter:                      616  (0.0343577); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.42
# Mc/sec: 2962.37
//
Query:       EFC37998.1  [L=2882]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.6e-31  105.3   5.1    2.3e-05   24.2   0.0   12.1 11  NHL           NHL repeat
    1.5e-29  102.0 232.4    0.00013   22.3  10.1   15.1 14  EGF_2         EGF-like domain
    9.3e-07   29.0   9.7       0.39   10.9   0.0    7.1  6  Arylesterase  Arylesterase
    2.3e-05   24.4   2.1         18    5.6   0.0    7.0  7  Str_synth     Strictosidine synthase
  ------ inclusion threshold ------
       0.16   12.0  20.9       0.53   10.3   0.1    6.1  7  SBBP          Beta-propeller repeat
       0.31   11.0   4.8        1.1    9.3   0.2    4.0  4  PD40          WD40-like Beta Propeller Repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.6   4.7e+03       8      19 ..      92     104 ..      92     109 .. 0.87
   2 !    9.2   0.1   0.00044       1.3       3      27 ..     154     179 ..     153     180 .. 0.91
   3 !    5.1   0.0    0.0088        26       1      27 [.     200     228 ..     200     229 .. 0.90
   4 !    6.3   0.0    0.0036        11       1      22 [.     262     284 ..     262     289 .. 0.82
   5 !    9.7   0.0   0.00031      0.93       1      26 [.     327     352 ..     327     354 .. 0.88
   6 !    5.7   0.0    0.0056        17       1      18 [.     568     585 ..     568     585 .. 0.93
   7 !    7.9   0.1    0.0011       3.4       1      19 [.     629     647 ..     629     651 .. 0.91
   8 ?    4.3   0.0     0.016        47       1      17 [.     815     831 ..     815     832 .. 0.91
   9 ?    3.0   0.0     0.039   1.2e+02       1      26 [.     966     990 ..     966     990 .. 0.92
  10 !   24.2   0.0   7.6e-09   2.3e-05       1      27 [.    1025    1052 ..    1025    1053 .. 0.94
  11 !   17.2   0.0   1.2e-06    0.0037       1      27 [.    1087    1114 ..    1087    1115 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.6
                 EEE.TTTEEEEEE CS
         NHL   8 avd.snGdiyVaD 19 
                 ++d ++Gd++++D
  EFC37998.1  92 CADiKTGDLFICD 104
                 678899******9 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00044
                 SEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvqv 27 
                 +Ph  avd  +G +y+ D++n+ +++
  EFC37998.1 154 RPHTCAVDpVDGSVYILDYYNSNIKK 179
                 68888*****************9975 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0088
                 BSSEEEEEEETTTEEEEEE..CCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaD..senhrvqv 27 
                 + +Ph +av++n  ++  D  s n+++++
  EFC37998.1 200 LTNPHTIAVSPNHIFIMEDgkSSNNQIRK 228
                 579******9999999999**99999986 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0036
                 BSSEEEEEEE.TTTEEEEEECCC CS
         NHL   1 fnyPhGvavd.snGdiyVaDsen 22 
                 f+ P G+av+ ++  +y++D  n
  EFC37998.1 262 FQTPGGIAVSsDGLYVYISDKTN 284
                 889*******7777788988665 PP

  == domain 5  score: 9.7 bits;  conditional E-value: 0.00031
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 ++yP+G++v+snGd++ +Ds   r++
  EFC37998.1 327 LSYPQGLTVLSNGDLIFSDSTVYRIR 352
                 78**************9998888876 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.0056
                 BSSEEEEEEETTTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVa 18 
                 +n P G+a+++n+d+++a
  EFC37998.1 568 LNTPKGIALTPNNDLIIA 585
                 689*************97 PP

  == domain 7  score: 7.9 bits;  conditional E-value: 0.0011
                 BSSEEEEEEETTTEEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaD 19 
                 f  P+ vav+ n++i+VaD
  EFC37998.1 629 FGGPQVVAVNANNEIFVAD 647
                 678999************* PP

  == domain 8  score: 4.3 bits;  conditional E-value: 0.016
                 BSSEEEEEEETTTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyV 17 
                 + +P+G+ +dsnGdiy+
  EFC37998.1 815 LMRPAGLFIDSNGDIYI 831
                 579*************8 PP

  == domain 9  score: 3.0 bits;  conditional E-value: 0.039
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P+++a++ +  iy +D+ nhrv+
  EFC37998.1 966 LNFPTSIAIV-GAKIYFCDTMNHRVR 990
                 799******5.*************96 PP

  == domain 10  score: 24.2 bits;  conditional E-value: 7.6e-09
                  BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL    1 fnyPhGvavd.snGdiyVaDsenhrvqv 27  
                  ++ P+G+ v+ +++ iyVaD++nh +++
  EFC37998.1 1025 LSKPTGLYVSsDGNTIYVADTGNHKIRK 1052
                  678**********************987 PP

  == domain 11  score: 17.2 bits;  conditional E-value: 1.2e-06
                  BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL    1 fnyPhGvavd.snGdiyVaDsenhrvqv 27  
                  ++yP+Gv+vd s ++iy+aD +++++++
  EFC37998.1 1087 LYYPTGVSVDeSRNEIYIADQGTQTIRK 1114
                  79******************99998875 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3  10.1   4.3e-08   0.00013       5      32 .]    1199    1224 ..    1191    1224 .. 0.90
   2 !   17.1  12.2   1.8e-06    0.0054       4      32 .]    1268    1296 ..    1266    1296 .. 0.88
   3 !   18.5   9.9   6.3e-07    0.0019       4      32 .]    1307    1335 ..    1305    1335 .. 0.90
   4 !    9.3   9.5   0.00048       1.4       6      32 .]    1349    1375 ..    1344    1375 .. 0.84
   5 !   14.5   8.2   1.1e-05     0.034       5      32 .]    1388    1414 ..    1383    1414 .. 0.86
   6 !   14.9   9.2   8.4e-06     0.025       5      32 .]    1427    1453 ..    1424    1453 .. 0.89
   7 !   15.0  11.3   8.2e-06     0.025       5      32 .]    1466    1492 ..    1463    1492 .. 0.90
   8 !   11.6  11.5   9.1e-05      0.27       5      32 .]    1505    1531 ..    1497    1531 .. 0.88
   9 !   18.4  10.2   7.1e-07    0.0021       5      32 .]    1544    1570 ..    1540    1570 .. 0.92
  10 !   15.8  12.1   4.5e-06     0.013       5      32 .]    1582    1608 ..    1575    1608 .. 0.86
  11 !   13.5   8.7   2.3e-05     0.069       6      32 .]    1622    1647 ..    1618    1647 .. 0.90
  12 !    8.3  12.4   0.00098       2.9       6      32 .]    1888    1918 ..    1884    1918 .. 0.83
  13 ?    1.1   2.0      0.17   5.2e+02      23      32 .]    1921    1930 ..    1920    1930 .. 0.95
  14 ?    2.5   2.0     0.064   1.9e+02      14      32 .]    2599    2620 ..    2596    2620 .. 0.76

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 4.3e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ghG+C    G C C+sgy+G +C
  EFC37998.1 1199 SLVCSGHGSCS--AGICTCSSGYYGTDC 1224
                  789********..9************** PP

  == domain 2  score: 17.1 bits;  conditional E-value: 1.8e-06
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +  C+ghG C ++   C+C+sgy+G +C
  EFC37998.1 1268 NtSYVCSGHGNCTSSD-SCSCNSGYSGSSC 1296
                  55789*******9888.6************ PP

  == domain 3  score: 18.5 bits;  conditional E-value: 6.3e-07
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+g G+Cv+++ qC+C+++y G +C
  EFC37998.1 1307 NsSNVCSGKGSCVSLN-QCQCQANYLGSNC 1335
                  44899********899.************* PP

  == domain 4  score: 9.3 bits;  conditional E-value: 0.00048
       EGF_2    6 eiCgg.hGtCvnqcGqCdCdsgyqGktC 32  
                    C++  GtC + +  C C s+y+G +C
  EFC37998.1 1349 QVCNNgKGTCSSYN-SCNCISNYFGTNC 1375
                  579998****9555.7************ PP

  == domain 5  score: 14.5 bits;  conditional E-value: 1.1e-05
       EGF_2    5 deiCgghGtCvnqcG.qCdCdsgyqGktC 32  
                   + C+ hG+C+  +   C+C+ +y+G +C
  EFC37998.1 1388 ALVCNSHGQCI--GYdTCQCSLNYYGSNC 1414
                  688********..6536************ PP

  == domain 6  score: 14.9 bits;  conditional E-value: 8.4e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   ++C g+G+C +   qCdC ++y G +C
  EFC37998.1 1427 TLTCTGNGVCTSHD-QCDCHTNYLGSDC 1453
                  679*******9777.************* PP

  == domain 7  score: 15.0 bits;  conditional E-value: 8.2e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ghG+C +++  C C s+y+G +C
  EFC37998.1 1466 SVSCSGHGQCSSFN-SCNCISNYFGSNC 1492
                  567********999.7************ PP

  == domain 8  score: 11.6 bits;  conditional E-value: 9.1e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   ++C+g+G C +   qC C ++y G +C
  EFC37998.1 1505 TLTCSGNGECTSHD-QCNCHTNYLGSDC 1531
                  679*******9777.************* PP

  == domain 9  score: 18.4 bits;  conditional E-value: 7.1e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+ghG+C++++  C C s+y+G +C
  EFC37998.1 1544 SDTCSGHGQCISFN-SCNCASNYYGSNC 1570
                  679********999.7************ PP

  == domain 10  score: 15.8 bits;  conditional E-value: 4.5e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g G C +  + C+C++g++G++C
  EFC37998.1 1582 SSVCSGKGNCTDY-NTCSCENGFYGADC 1608
                  689*******744.49************ PP

  == domain 11  score: 13.5 bits;  conditional E-value: 2.3e-05
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g+G+Cv++   C C  gy+G  C
  EFC37998.1 1622 SVCNGNGSCVSTD-ICNCTEGYFGQFC 1647
                  57*******9777.9***********9 PP

  == domain 12  score: 8.3 bits;  conditional E-value: 0.00098
       EGF_2    6 eiCgghGtCvnqcGqCdC.....dsgyqGktC 32  
                  e+C++hG C+   G C C     +  ++G +C
  EFC37998.1 1888 ETCSNHGECNV-KGFCTCysnsnEGYWTGSSC 1918
                  79*******74.46****99998888999999 PP

  == domain 13  score: 1.1 bits;  conditional E-value: 0.17
       EGF_2   23 CdsgyqGktC 32  
                  C+sgy+G +C
  EFC37998.1 1921 CQSGYYGESC 1930
                  *********9 PP

  == domain 14  score: 2.5 bits;  conditional E-value: 0.064
       EGF_2   14 CvnqcG.....qCdCdsgyqGktC 32  
                  C   +G      C+C  gy G +C
  EFC37998.1 2599 CK--NGvevanHCECAEGYIGHNC 2620
                  55..66444435**********99 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.9   0.0   0.00013      0.39      48      85 ..     257     294 ..     242     295 .. 0.85
   2 ?   -0.9   0.1      0.66     2e+03      43      66 ..     558     581 ..     526     586 .. 0.78
   3 ?   -0.6   0.1      0.51   1.5e+03      37      70 ..     799     831 ..     789     835 .. 0.86
   4 ?   -0.3   0.1      0.41   1.2e+03      47      78 ..     897     928 ..     874     936 .. 0.74
   5 !   10.1   0.0   0.00023      0.69      50      78 ..    1022    1050 ..     971    1055 .. 0.87
   6 !    5.5   0.0    0.0067        20      51      76 ..    1085    1110 ..    1075    1116 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00013
  Arylesterase  48 vvasglssanGInidadkkyiyvadilresihvmkkhk 85 
                    +  +++++ GI +++d  y+y++d ++  i + + ++
    EFC37998.1 257 DASVRFQTPGGIAVSSDGLYVYISDKTNSVIRRWNTQT 294
                   56679*********************999887776665 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.66
  Arylesterase  43 psevkvvasglssanGInidadkk 66 
                   +++v   a +l+++ GI + +++ 
    EFC37998.1 558 ANNVAATATSLNTPKGIALTPNND 581
                   57899999*********9988765 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.51
  Arylesterase  37 avvYyspsevkvvasglssanGInidadkkyiyv 70 
                    + +y++++ +    +l  + G+ id++   iy+
    EFC37998.1 799 DYSFYNGENTIALRTKLMRPAGLFIDSNGD-IYI 831
                   688***********************9864.566 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.41
  Arylesterase  47 kvvasglssanGInidadkkyiyvadilresi 78 
                     ++sg++++ G+  ++    iy +++  + i
    EFC37998.1 897 TYQISGIQFPFGLAKSSTTGEIYYSESEYHRI 928
                   35899999999999999999999988877777 PP

  == domain 5  score: 10.1 bits;  conditional E-value: 0.00023
  Arylesterase   50 asglssanGInidadkkyiyvadilresi 78  
                      +ls ++G+ +++d   iyvad  +++i
    EFC37998.1 1022 LTKLSKPTGLYVSSDGNTIYVADTGNHKI 1050
                    56899*******************99998 PP

  == domain 6  score: 5.5 bits;  conditional E-value: 0.0067
  Arylesterase   51 sglssanGInidadkkyiyvadilre 76  
                    ++l+ ++G+ +d  +  iy+ad   +
    EFC37998.1 1085 AKLYYPTGVSVDESRNEIYIADQGTQ 1110
                    67999****************97655 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0      0.02        59      58      85 ..     264     290 ..     260     294 .. 0.80
   2 ?   -1.3   0.0      0.82   2.4e+03       2      25 ..     332     353 ..     325     359 .. 0.68
   3 ?    1.8   0.0     0.091   2.7e+02       6      73 ..     523     585 ..     519     598 .. 0.63
   4 ?    3.5   0.0     0.027        80       1      18 [.     694     711 ..     694     722 .. 0.89
   5 ?   -0.4   0.0      0.42   1.2e+03      30      70 ..     846     886 ..     820     899 .. 0.69
   6 !    5.6   0.0    0.0059        18      52      83 ..    1021    1052 ..    1012    1057 .. 0.88
   7 ?   -2.3   0.0       1.6   4.9e+03      55      81 ..    1086    1112 ..    1085    1118 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.02
   Str_synth  58 fanGialsedgsfvlvcetamkrisryw 85 
                  + Gia+s+dg +v +++ + +  +r w
  EFC37998.1 264 TPGGIAVSSDGLYVYISDKTNSV-IRRW 290
                 688*************9988776.5555 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.82
   Str_synth   2 aldvdeetgvlyftdsSskydrrq 25 
                 +l+v ++ g l+f+ds ++y  r+
  EFC37998.1 332 GLTVLSN-GDLIFSDS-TVYRIRK 353
                 4677777.77777774.5565554 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.091
   Str_synth   6 deetgvlyftdsSskydrrqvllallegdktGrllkydkstkvvkvlldkLyfanGialsedgsfvlv 73 
                 d+ ++ +yf d  +  +++++ + +++  + G   +y ++  ++   +  L  + Gial+++++ ++ 
  EFC37998.1 523 DQSNNDIYFVDDNY-IKKIDYATGVMSIYAGGG-ASYANNVAAT---ATSLNTPKGIALTPNNDLIIA 585
                 55556666666432.234566666665555544.3555555555...7899************99875 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.027
   Str_synth   1 daldvdeetgvlyftdsS 18 
                 +++d+++ t++lyf ds 
  EFC37998.1 694 NDMDIHPSTNELYFCDSE 711
                 89**************85 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.42
   Str_synth  30 llegdktGrllkydkstkvvkvlldkLyfanGialsedgsf 70 
                      +  r+ k+d +t  ++++l +   +   + + d+++
  EFC37998.1 846 STPSMNYARIAKFDATTGRINTILGNFLLPTASSQTADNTY 886
                 444556789***********999999888877777777776 PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.0059
   Str_synth   52 lldkLyfanGialsedgsfvlvcetamkrisr 83  
                  ll kL+ + G+ +s+dg+ + v++t  ++i +
  EFC37998.1 1021 LLTKLSKPTGLYVSSDGNTIYVADTGNHKIRK 1052
                  899**********************9999655 PP

  == domain 7  score: -2.3 bits;  conditional E-value: 1.6
   Str_synth   55 kLyfanGialsedgsfvlvcetamkri 81  
                  kLy++ G+++ e ++ + +++  ++ i
  EFC37998.1 1086 KLYYPTGVSVDESRNEIYIADQGTQTI 1112
                  577777777777777666666666655 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0         2   5.9e+03       9      23 ..     197     211 ..     192     211 .. 0.83
   2 ?   -3.8   0.3       4.6   1.4e+04      15      28 ..     265     279 ..     264     285 .. 0.72
   3 ?   -3.4   0.2       3.5     1e+04      21      26 ..     784     789 ..     783     789 .. 0.90
   4 ?    7.4   0.1    0.0014       4.2      12      32 ..     815     835 ..     809     838 .. 0.82
   5 ?    6.2   0.2    0.0034        10      14      29 ..    1027    1043 ..    1022    1050 .. 0.83
   6 ?   10.3   0.1   0.00018      0.53       9      29 ..    1084    1105 ..    1082    1105 .. 0.88
   7 ?   -2.7   0.0       2.1   6.3e+03       3      16 ..    2121    2134 ..    2120    2135 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2
        SBBP   9 pgastygngIavDsn 23 
                 +++ t+++ Iav +n
  EFC37998.1 197 SQTLTNPHTIAVSPN 211
                 67889******9765 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 4.6
        SBBP  15 gngIavDsnGN.iYv 28 
                 + gIav s+G  +Y+
  EFC37998.1 265 PGGIAVSSDGLyVYI 279
                 779***999944776 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 3.5
        SBBP  21 DsnGNi 26 
                 DsnGNi
  EFC37998.1 784 DSNGNI 789
                 9****8 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.0014
        SBBP  12 stygngIavDsnGNiYvtGsT 32 
                  + + g+ +DsnG iY++ s 
  EFC37998.1 815 LMRPAGLFIDSNGDIYIGASG 835
                 56688999*********9886 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.0034
        SBBP   14 ygngIavDsnGN.iYvt 29  
                  +++g++v s+GN iYv+
  EFC37998.1 1027 KPTGLYVSSDGNtIYVA 1043
                  79**************8 PP

  == domain 6  score: 10.3 bits;  conditional E-value: 0.00018
        SBBP    9 pgastygngIavDsnGN.iYvt 29  
                  + + +y++g+ vD++ N iY++
  EFC37998.1 1084 TAKLYYPTGVSVDESRNeIYIA 1105
                  56788***************97 PP

  == domain 7  score: -2.7 bits;  conditional E-value: 2.1
        SBBP    3 stqlGgpgastygn 16  
                  s +lG++++ ty n
  EFC37998.1 2121 SSYLGISSSVTYSN 2134
                  569******88765 PP

>> PD40  WD40-like Beta Propeller Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.67     2e+03      12      26 ..     266     280 ..     266     282 .. 0.87
   2 ?   -1.5   0.1      0.88   2.6e+03      14      25 ..     750     760 ..     746     760 .. 0.90
   3 ?   -0.2   0.0      0.34     1e+03      16      25 ..    1033    1042 ..    1029    1052 .. 0.83
   4 ?    9.3   0.2   0.00037       1.1      11      27 ..    2065    2081 ..    2063    2082 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.67
                 EEEEE-TTSSEEEEE CS
        PD40  12 gaPsfSPDGkrlaFs 26 
                 g++++S DG + ++s
  EFC37998.1 266 GGIAVSSDGLYVYIS 280
                 5799*****999986 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.88
                 EEE-TTSSEEEE CS
        PD40  14 PsfSPDGkrlaF 25 
                 +sfSP G +l+F
  EFC37998.1 750 ISFSPSG-TLYF 760
                 79*****.9998 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.34
                  E-TTSSEEEE CS
        PD40   16 fSPDGkrlaF 25  
                  +S DG++++ 
  EFC37998.1 1033 VSSDGNTIYV 1042
                  79******95 PP

  == domain 4  score: 9.3 bits;  conditional E-value: 0.00037
                  EEEEEE-TTSSEEEEEE CS
        PD40   11 egaPsfSPDGkrlaFsS 27  
                  +g+ sfS DGk+l++++
  EFC37998.1 2065 DGSSSFSADGKTLIYTW 2081
                  67889**********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2882 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1613  (0.089966); expected 358.6 (0.02)
Passed bias filter:                      250  (0.0139439); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.43u 0.33s 00:00:01.76 Elapsed: 00:00:00.59
# Mc/sec: 14624.96
//
Query:       EFC37999.1  [L=4292]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-40  139.1  19.4    1.2e-38  133.2  10.4    3.2  2  REJ       REJ domain
     0.0012   19.2  27.2     0.0017   18.7   6.5   43.3 47  EGF_2     EGF-like domain
  ------ inclusion threshold ------
      0.038   13.3   2.7        5.3    6.5   0.1    3.0  2  LVIVD     LVIVD repeat


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   1.5   7.2e-05      0.43      93     209 ..    3398    3497 ..    3362    3590 .. 0.75
   2 !  133.2  10.4   1.9e-42   1.2e-38     158     437 ..    3650    3915 ..    3596    3928 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 7.2e-05
         REJ   93 rvigyr.gnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrs.rk 187 
                   +i+   g+++Ld+s S+  d+ +     l Y+W+ +               +++++  s ++ + st+ ++f+as l  + ty +++tv+ +   k
  EFC37999.1 3398 STISKAcGSIYLDASGSSSLDRRS-----LIYSWTTTLAP------------SSTEVLDS-IISKLSTPGVKFSASDLDVG-TYVVQVTVKSSFsLK 3475
                  44454459************8884.....88*****3333............44444444.88899999************.8*******8886778 PP

         REJ  188 sasteqtilvvdgepplvsiec 209 
                  ++ +++t  v    pp++si+ 
  EFC37999.1 3476 ESVASVTFSVIAATPPTISIKN 3497
                  9*******************86 PP

  == domain 2  score: 133.2 bits;  conditional E-value: 1.9e-42
         REJ  158 stssltfpaselvanltynftltvskrsrksasteqtilv.vd..gepplvsiecisncn.gkvnpndrlvllasclncakdlkdvt.feWslsqts 249 
                   +s+l++  +++++++ y ft t +k++r ++++++ ++v ++  + + +vsi+ ++  +   v+p+++l+l++ +l+    l ++  f+W      
  EFC37999.1 3650 DQSTLKL-VKTMTPGV-YSFTATYTKSTR-TSTASVKVTVsDQskSTVLRVSISAPKDADlVAVDPSSDLILQTTSLDT---LTSARlFTW------ 3734
                  5566666.57899995.************.555555555515422456677888777665247889999****999988...555555***...... PP

         REJ  250 eeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaftvrC.qgwtDkdqPL 345 
                       +  ++t   +   +++++vi ++ L +g+sy+lt+  ++ +g+ksg as sf+vn+pPt Gt++v P++g+al+++f+++C +gw+D+++PL
  EFC37999.1 3735 -----SSSDFTFDSSVDISKQYIVIPKSLLAPGASYTLTI--KVVDGQKSGEASLSFTVNSPPTVGTLEVSPKSGIALSDEFKISCgNGWSDPQLPL 3824
                  .....2234677788888889*******************..9999999************************************************ PP

         REJ  346 gYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarvsvsltitVkppavnns......tieellenrtrnenelskl 436 
                  ++++ ys  ++++ +rll e+s+  s  + LP G        +++v+V D+kga++++++t+ V  p+ ++        ++    ++++++++ls++
  EFC37999.1 3825 SFAF-YSKTSTDTNWRLLKEKSETRSFGTSLPAGEL------EIKVVVFDSKGASSETTTTVSVSMPKDASTaitaltSSSSGTMTTSSVSSALSVI 3914
                  ****.******************************9......9*********************999988884544322233333344444455544 PP

         REJ  437 l 437 
                  +
  EFC37999.1 3915 Q 3915
                  4 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   5.7   0.00098       5.8       7      32 .]     680     713 ..     675     713 .. 0.87
   2 !   15.1  11.2   3.7e-06     0.022       4      32 .]     731     759 ..     725     759 .. 0.90
   3 !   12.9  12.0   1.8e-05      0.11       5      32 .]     772     798 ..     768     798 .. 0.89
   4 !   17.7  12.7   5.8e-07    0.0035       5      32 .]     811     837 ..     803     837 .. 0.88
   5 !   18.7   6.5   2.8e-07    0.0017       5      32 .]     850     876 ..     846     876 .. 0.90
   6 ?   -0.5   1.8      0.29   1.7e+03       7      26 ..     891     911 ..     886     913 .. 0.79
   7 ?   -1.9   1.5      0.76   4.5e+03      13      22 ..     919     928 ..     919     931 .. 0.88
   8 ?   -2.0   4.3      0.84     5e+03       1      18 [.     961     979 ..     961    1001 .. 0.70
   9 ?   -0.1   1.7      0.21   1.2e+03       1      15 [.    1069    1085 ..    1069    1090 .. 0.77
  10 ?   -8.7   6.1         3   1.8e+04       8      21 ..    1119    1134 ..    1114    1140 .. 0.49
  11 ?   -5.3   4.4         3   1.8e+04       1      21 [.    1144    1164 ..    1144    1165 .. 0.69
  12 ?   -4.6   5.7         3   1.8e+04       1      18 [.    1261    1279 ..    1261    1287 .. 0.84
  13 ?   -4.4   1.4         3   1.8e+04       1      21 [.    1300    1322 ..    1300    1323 .. 0.75
  14 ?   -7.5   4.8         3   1.8e+04      17      22 ..    1382    1388 ..    1378    1396 .. 0.43
  15 ?   -3.9   3.9         3   1.8e+04       4      15 ..    1439    1455 ..    1430    1477 .. 0.72
  16 ?   -7.0   4.6         3   1.8e+04       5      14 ..    1495    1504 ..    1468    1520 .. 0.58
  17 ?   -8.8  10.3         3   1.8e+04       1      32 []    1523    1552 ..    1514    1552 .. 0.69
  18 ?   -8.2   5.6         3   1.8e+04       1      15 [.    1596    1611 ..    1596    1618 .. 0.74
  19 ?  -14.1  13.2         3   1.8e+04       5      15 ..    1755    1764 ..    1733    1786 .. 0.61
  20 ?   -9.4   7.9         3   1.8e+04       6      22 ..    1917    1934 ..    1913    1952 .. 0.53
  21 ?   -4.3   3.0         3   1.8e+04      13      21 ..    1951    1959 ..    1937    1960 .. 0.72
  22 ?   -7.5   6.7         3   1.8e+04       5      21 ..    1976    1988 ..    1972    2011 .. 0.70
  23 ?  -11.7  10.3         3   1.8e+04       1      15 [.    2007    2024 ..    1984    2031 .. 0.59
  24 ?   -2.2   0.9      0.94   5.6e+03       6      15 ..    2074    2083 ..    2068    2098 .. 0.67
  25 ?   -6.4   7.3         3   1.8e+04       5      18 ..    2097    2109 ..    2087    2118 .. 0.67
  26 ?   -9.8  12.2         3   1.8e+04       1      21 [.    2143    2163 ..    2132    2164 .. 0.84
  27 ?   -6.7   8.6         3   1.8e+04       1      18 [.    2224    2243 ..    2224    2268 .. 0.75
  28 ?  -12.8  13.1         3   1.8e+04       1      14 [.    2382    2399 ..    2365    2420 .. 0.67
  29 ?   -9.7   8.8         3   1.8e+04       1      18 [.    2460    2477 ..    2453    2485 .. 0.72
  30 ?  -11.8  10.9         3   1.8e+04      10      10 ..    2513    2513 ..    2488    2536 .. 0.57
  31 !    7.2   3.2    0.0011       6.8      21      32 .]    2608    2619 ..    2602    2619 .. 0.92
  32 !    7.7   9.5   0.00074       4.4       6      32 .]    2629    2656 ..    2623    2656 .. 0.80
  33 !   10.7  11.4   8.7e-05      0.52       1      32 []    2664    2693 ..    2660    2693 .. 0.84
  34 !   12.5   9.9   2.4e-05      0.15       8      32 .]    2705    2730 ..    2698    2730 .. 0.86
  35 !   10.7   7.9     9e-05      0.54       8      32 .]    2742    2767 ..    2738    2767 .. 0.87
  36 !   15.7   8.4   2.4e-06     0.015       8      32 .]    2779    2804 ..    2771    2804 .. 0.84
  37 !    9.7   8.4   0.00018       1.1       8      32 .]    2816    2841 ..    2811    2841 .. 0.86
  38 !   11.1   9.2   6.6e-05       0.4       8      32 .]    2853    2878 ..    2845    2878 .. 0.85
  39 !   10.8   7.8   8.1e-05      0.48       8      32 .]    2890    2915 ..    2883    2915 .. 0.84
  40 !   10.4   9.5   0.00011      0.66       5      32 .]    2921    2949 ..    2917    2949 .. 0.84
  41 !   12.5   9.2   2.5e-05      0.15       8      32 .]    2961    2986 ..    2954    2986 .. 0.86
  42 ?    2.7  10.1     0.028   1.7e+02       1      32 []    2991    3022 ..    2991    3022 .. 0.86
  43 !   12.6   4.8   2.3e-05      0.14       1      32 []    3033    3064 ..    3031    3064 .. 0.87
  44 ?    2.0   1.0     0.048   2.9e+02      17      28 ..    3074    3085 ..    3066    3090 .. 0.78
  45 ?   -0.4   9.2      0.26   1.6e+03       1      27 [.    3098    3126 ..    3098    3127 .. 0.76
  46 ?    0.9   5.7       0.1   6.1e+02       7      32 .]    3143    3163 ..    3133    3163 .. 0.77
  47 ?    2.0   5.3     0.045   2.7e+02      14      32 .]    3271    3290 ..    3270    3290 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00098
       EGF_2   7 iCgghGtCvnqcG.........qCdCdsgyqGktC 32 
                  C+g+G+C  +            C+C +g  G++C
  EFC37999.1 680 VCNGRGQCT-FIYdkskkvgsgICKCRTGLNGADC 713
                 7*******7.6888888877777************ PP

  == domain 2  score: 15.1 bits;  conditional E-value: 3.7e-06
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ghGtC+++  +C+C +++ G++C
  EFC37999.1 731 NdSSVCSGHGTCDSLD-KCSCTPNHNGNQC 759
                 35789********999.************* PP

  == domain 3  score: 12.9 bits;  conditional E-value: 1.8e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C  +  +C C+sg+ G +C
  EFC37999.1 772 STVCSGNGVCSGFD-NCTCNSGFNGSNC 798
                 678********777.8************ PP

  == domain 4  score: 17.7 bits;  conditional E-value: 5.8e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + CgghG+C+++   C+C+sgy+G +C
  EFC37999.1 811 TSVCGGHGKCIAKD-TCKCQSGYSGSQC 837
                 578********888.9************ PP

  == domain 5  score: 18.7 bits;  conditional E-value: 2.8e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghGtC ++   C C ++++G +C
  EFC37999.1 850 SLVCSGHGTCSKPD-TCTCTNSFTGSSC 876
                 789********999.9************ PP

  == domain 6  score: -0.5 bits;  conditional E-value: 0.29
       EGF_2   7 iCgg..hGtCvnqcGqCdCdsg 26 
                  Cg    G C+++  +C C++g
  EFC37999.1 891 VCGSvdAGWCESKD-NCACKPG 911
                 56666679999888.7***998 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 0.76
       EGF_2  13 tCvnqcGqCd 22 
                 tC ++cG C+
  EFC37999.1 919 TCKRPCGSCS 928
                 7*99***995 PP

  == domain 8  score: -2.0 bits;  conditional E-value: 0.84
       EGF_2   1 Csas.deiCgghGtCvnqc 18 
                 C ++   +Cg  G+C  +c
  EFC37999.1 961 CTTNgMYFCGSSGVCAFEC 979
                 7777778898999987445 PP

  == domain 9  score: -0.1 bits;  conditional E-value: 0.21
       EGF_2    1 Csas..deiCgghGtCv 15  
                  C++   + +C+ +G Cv
  EFC37999.1 1069 CESVpgKPYCNKNGACV 1085
                  666667889*******7 PP

  == domain 10  score: -8.7 bits;  conditional E-value: 3
       EGF_2    8 CgghGtCvnqcGq..C 21  
                  C  +  C n +G+  C
  EFC37999.1 1119 CTEDANCKNVNGKptC 1134
                  5555555555554222 PP

  == domain 11  score: -5.3 bits;  conditional E-value: 3
       EGF_2    1 CsasdeiCgghG...tCvnqcGqC 21  
                  Csa d +C ++G   +C+  + qC
  EFC37999.1 1144 CSA-DKDCPQNGvnkYCI--NSQC 1164
                  898.57798888555687..6667 PP

  == domain 12  score: -4.6 bits;  conditional E-value: 3
       EGF_2    1 Csas..deiCgghGtCvnqc 18  
                  C+++  + +C+  G+C ++c
  EFC37999.1 1261 CPQDgaNKYCK-SGKCATAC 1279
                  888889999*8.6***9766 PP

  == domain 13  score: -4.4 bits;  conditional E-value: 3
       EGF_2    1 Csas..deiCgghGtCvnqcGqC 21  
                  C +   ++iC  +  C ++ G C
  EFC37999.1 1300 CATYnlNDICESNDDCPSKFGAC 1322
                  77777888999998887666777 PP

  == domain 14  score: -7.5 bits;  conditional E-value: 3
       EGF_2   17 qc.GqCd 22  
                   c G+C+
  EFC37999.1 1382 RCnGECS 1388
                  3333332 PP

  == domain 15  score: -3.9 bits;  conditional E-value: 3
       EGF_2    4 s...deiCgg..hGtCv 15  
                      d++C+    G+C 
  EFC37999.1 1439 EctkDLECSMpgKGKCQ 1455
                  43346777765566665 PP

  == domain 16  score: -7.0 bits;  conditional E-value: 3
       EGF_2    5 deiCgghGtC 14  
                  + +C  +  C
  EFC37999.1 1495 SYECTSNADC 1504
                  3344444444 PP

  == domain 17  score: -8.8 bits;  conditional E-value: 3
       EGF_2    1 CsasdeiCgg..hGtCvnqcGqCdCdsgyq.GktC 32  
                  Cs+ d  C     G+C    +  +C+++ + G++C
  EFC37999.1 1523 CSD-DQPCTDpwFGKCL--SN--YCFPSCStGNDC 1552
                  665.5778878888887..33..685554448888 PP

  == domain 18  score: -8.2 bits;  conditional E-value: 3
       EGF_2    1 Csas.deiCgghGtCv 15  
                  C++s + +C ++  C 
  EFC37999.1 1596 CMNStCAYCLQNSDCP 1611
                  9988888998887774 PP

  == domain 19  score: -14.1 bits;  conditional E-value: 3
       EGF_2    5 deiCgghGtCv 15  
                  +++C ++G C 
  EFC37999.1 1755 KTAC-VDGRCT 1764
                  3444.356666 PP

  == domain 20  score: -9.4 bits;  conditional E-value: 3
       EGF_2    6 eiCgg...hGtCvnqcGqCd 22  
                  ++C+g   + +C   +++C+
  EFC37999.1 1917 SDCSGtanRHKCS--GNKCV 1934
                  5566555555555..44443 PP

  == domain 21  score: -4.3 bits;  conditional E-value: 3
       EGF_2   13 tCvnqcGqC 21  
                  tC++++G C
  EFC37999.1 1951 TCNTTTGDC 1959
                  899999999 PP

  == domain 22  score: -7.5 bits;  conditional E-value: 3
       EGF_2    5 deiCgghGtCvnqcGqC 21  
                  +++C+  G+C  +   C
  EFC37999.1 1976 NSYCR-SGYCKPE---C 1988
                  67787.5888733...3 PP

  == domain 23  score: -11.7 bits;  conditional E-value: 3
       EGF_2    1 Csas...deiCgghGtCv 15  
                  Cs+    d+ C+    C+
  EFC37999.1 2007 CSPEctlDSHCNSTSACD 2024
                  333333344444444454 PP

  == domain 24  score: -2.2 bits;  conditional E-value: 0.94
       EGF_2    6 eiCgghGtCv 15  
                   +C+  G C+
  EFC37999.1 2074 PYCNATGDCE 2083
                  6788888884 PP

  == domain 25  score: -6.4 bits;  conditional E-value: 3
       EGF_2    5 deiCgghGtCvnqc 18  
                    iC+  GtC+ +c
  EFC37999.1 2097 YPICN-KGTCDIEC 2109
                  45786.69998455 PP

  == domain 26  score: -9.8 bits;  conditional E-value: 3
       EGF_2    1 Csas.deiCgghGtCvnqcGqC 21  
                  C +  +  C  +G C+ + G C
  EFC37999.1 2143 CVNTkCAPCTSDGFCDGTKG-C 2163
                  55556778*******97777.7 PP

  == domain 27  score: -6.7 bits;  conditional E-value: 3
       EGF_2    1 Csas.deiCgg.hGtCvnqc 18  
                  C+++    C+   GtC +qc
  EFC37999.1 2224 CKDPkYPVCNTkYGTCASQC 2243
                  66666677888889999888 PP

  == domain 28  score: -12.8 bits;  conditional E-value: 3
       EGF_2    1 Csas...deiCgg.hGtC 14  
                  Csa+   +++Cg+  ++C
  EFC37999.1 2382 CSAGctdNSQCGNaYEVC 2399
                  444444456666666666 PP

  == domain 29  score: -9.7 bits;  conditional E-value: 3
       EGF_2    1 Csas.deiCgghGtCvnqc 18  
                  C+++ +  C++  +Cv+qc
  EFC37999.1 2460 CKDPnKPKCSN-TKCVEQC 2477
                  77777777875.6788666 PP

  == domain 30  score: -11.8 bits;  conditional E-value: 3
       EGF_2   10 g 10  
                  g
  EFC37999.1 2513 G 2513
                  1 PP

  == domain 31  score: 7.2 bits;  conditional E-value: 0.0011
       EGF_2   21 CdCdsgyqGktC 32  
                  C C++gy+GktC
  EFC37999.1 2608 CNCNTGYSGKTC 2619
                  ************ PP

  == domain 32  score: 7.7 bits;  conditional E-value: 0.00074
       EGF_2    6 eiCgghGtCvnqc.G...qCdCdsgyqGktC 32  
                   +C + G+Cv  + G   +C C++gy G+ C
  EFC37999.1 2629 KAC-VYGQCV--GsGatpKCICNAGYEGDLC 2656
                  456.48****..6568888***********9 PP

  == domain 33  score: 10.7 bits;  conditional E-value: 8.7e-05
       EGF_2    1 CsasdeiCgghGtCvnqcG..qCdCdsgyqGktC 32  
                  Cs   ++C  +G+C n +G  +C C+sg+ G+ C
  EFC37999.1 2664 CS---LQCV-NGQCSNVNGvqKCNCNSGFEGDLC 2693
                  43...4585.7***999**766***********9 PP

  == domain 34  score: 12.5 bits;  conditional E-value: 2.4e-05
       EGF_2    8 CgghGtCvnqcG..qCdCdsgyqGktC 32  
                  C ++G+C n++G  +C C++gy G+ C
  EFC37999.1 2705 C-VNGQCTNTTGiaKCNCNTGYEGDLC 2730
                  6.58********888***********9 PP

  == domain 35  score: 10.7 bits;  conditional E-value: 9e-05
       EGF_2    8 CgghGtCvnqcG..qCdCdsgyqGktC 32  
                  C ++G+C n +G  +C C++g+ G+ C
  EFC37999.1 2742 C-VNGQCSNVNGvmKCICSPGFEGDLC 2767
                  7.47***999**777***********9 PP

  == domain 36  score: 15.7 bits;  conditional E-value: 2.4e-06
       EGF_2    8 CgghGtCvnqcG..qCdCdsgyqGktC 32  
                  C ++G+C n++G  +C+C++gy G+ C
  EFC37999.1 2779 C-VNGQCANTTGiaKCVCNTGYEGDLC 2804
                  6.58****9***888***********9 PP

  == domain 37  score: 9.7 bits;  conditional E-value: 0.00018
       EGF_2    8 CgghGtCvnqcG..qCdCdsgyqGktC 32  
                  C ++G+C n +G  +C+C+ g+ G+ C
  EFC37999.1 2816 C-VNGQCTNVNGvmKCVCNYGFEGDLC 2841
                  6.48***999**777***********9 PP

  == domain 38  score: 11.1 bits;  conditional E-value: 6.6e-05
       EGF_2    8 CgghGtCvnqcG..qCdCdsgyqGktC 32  
                  C + G+C n++G  +C C++g+ G+ C
  EFC37999.1 2853 C-VSGQCSNTTGiaKCNCNTGFEGDLC 2878
                  5.58********888***********9 PP

  == domain 39  score: 10.8 bits;  conditional E-value: 8.1e-05
       EGF_2    8 CgghGtCvnqcG..qCdCdsgyqGktC 32  
                  C ++G C n++G  +C+C++g+ G+ C
  EFC37999.1 2890 C-VNGLCSNTTGtaRCMCNNGFEGDLC 2915
                  6.48****9***767***********9 PP

  == domain 40  score: 10.4 bits;  conditional E-value: 0.00011
       EGF_2    5 deiCgghGtCvnqcG..qCdCdsgyqGktC 32  
                  ++ C + G C+n +G  +C C+sg+ G+ C
  EFC37999.1 2921 NLLC-VYGRCDNVNGvsKCTCNSGFEGDLC 2949
                  5567.48****9***777***********9 PP

  == domain 41  score: 12.5 bits;  conditional E-value: 2.5e-05
       EGF_2    8 CgghGtCvnqcG..qCdCdsgyqGktC 32  
                  C + G+C n++G  +C C+sgy G+ C
  EFC37999.1 2961 C-VSGQCANSTGiaKCNCNSGYEGDLC 2986
                  5.47********888***********9 PP

  == domain 42  score: 2.7 bits;  conditional E-value: 0.028
       EGF_2    1 CsasdeiCgghGtC.vnqcGq..CdCdsgyqGktC 32  
                  Cs     C ++G C  ++ ++  C+C +gy+G  C
  EFC37999.1 2991 CSKQ---CLNGGLCkFDASNKefCSCINGYSGSLC 3022
                  7765...*******876776789**********99 PP

  == domain 43  score: 12.6 bits;  conditional E-value: 2.3e-05
       EGF_2    1 CsasdeiCgghGtCvnqcG..qCdC.dsgyqGktC 32  
                  C+   ++C ++G+C n++G  +C+C ++ + G+ C
  EFC37999.1 3033 CK---LTCLNGGVCLNSTGiaKCQCtSDLFVGDLC 3064
                  54...67************888***7777889999 PP

  == domain 44  score: 2.0 bits;  conditional E-value: 0.048
       EGF_2   17 qcGqCdCdsgyq 28  
                  q G+C+C++g+ 
  EFC37999.1 3074 QKGVCVCPFGFN 3085
                  4579*****995 PP

  == domain 45  score: -0.4 bits;  conditional E-value: 0.26
       EGF_2    1 CsasdeiCgghGtC..vnqcG.q..CdCdsgy 27  
                  C ++   Cg+ G+C   +++G q  C+C+ +y
  EFC37999.1 3098 CADG---CGQYGQCvyKDTTGyQgyCKCQEKY 3126
                  8887...*******64345576477***9877 PP

  == domain 46  score: 0.9 bits;  conditional E-value: 0.1
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                    + +G Cv      +C++ ++G++C
  EFC37999.1 3143 VKNAQGNCV--K---VCPPEFTGDDC 3163
                  456677777..7...8********** PP

  == domain 47  score: 2.0 bits;  conditional E-value: 0.045
       EGF_2   14 CvnqcGqCd.CdsgyqGktC 32  
                  C++++ +C+ C+sg++G +C
  EFC37999.1 3271 CNAEGANCQtCKSGWFGEKC 3290
                  7644446866********** PP

>> LVIVD  LVIVD repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.1   0.00088       5.3       6      22 ..     389     404 ..     386     406 .. 0.80
   2 ?    5.6   0.5    0.0016       9.5       4      17 ..     539     552 ..     536     559 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.00088
       LVIVD   6 dvavsGnYaYvAdqdng 22 
                  +a +GnY+Y+A + ng
  EFC37999.1 389 KIAKKGNYLYIAEG-NG 404
                 57889*******55.64 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0016
       LVIVD   4 aqdvavsGnYaYvA 17 
                 + +vav G+Y+Yv 
  EFC37999.1 539 VLNVAVAGDYVYVF 552
                 569*********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (4292 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1460  (0.0814323); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.97u 0.37s 00:00:02.34 Elapsed: 00:00:00.70
# Mc/sec: 18489.46
//
Query:       EFC38000.1  [L=144]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.2e-10   40.0   6.7    4.7e-10   39.4   6.7    1.4  1  Bap31      Bap31/Bap29 transmembrane region
  ------ inclusion threshold ------
      0.025   13.1   2.1      0.032   12.8   2.1    1.1  1  MFS_2      MFS/sugar transport protein
      0.031   14.6   2.9       0.04   14.2   2.6    1.4  1  ASFV_L11L  African swine fever virus (ASFV) L11L protein
      0.033   13.1   4.8        0.9    8.4   4.8    2.0  1  MFS_1      Major Facilitator Superfamily
      0.039   12.6   0.4      0.042   12.5   0.4    1.1  1  Ndc1_Nup   Nucleoporin protein Ndc1-Nup
      0.046   13.8   0.7      0.046   13.8   0.7    2.1  3  ETRAMP     Malarial early transcribed membrane protein (ETRAM
      0.089   12.9   3.1       0.15   12.2   1.4    2.3  2  YrhC       YrhC-like protein
        0.2   11.6   5.3      0.093   12.7   2.9    1.7  2  DUF485     Protein of unknown function, DUF485
       0.21   10.6   4.1       0.28   10.2   4.1    1.2  1  DUF898     Bacterial protein of unknown function (DUF898)
       0.95   10.1   0.0       0.95   10.1   0.0    3.1  3  OAD_gamma  Oxaloacetate decarboxylase, gamma chain
        2.6    7.6   7.3        3.9    7.1   7.3    1.5  1  DUF4131    Domain of unknown function (DUF4131)
        3.6    7.8   9.6         25    5.1   9.6    1.9  1  EI24       Etoposide-induced protein 2.4 (EI24)


Domain annotation for each model (and alignments):
>> Bap31  Bap31/Bap29 transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.4   6.7   3.2e-13   4.7e-10       4     115 ..       3     106 ..       1     130 [. 0.75

  Alignments for each domain:
  == domain 1  score: 39.4 bits;  conditional E-value: 3.2e-13
       Bap31   4 qytlvaalLvaeivv.vllLvlPlpsavrkklfksllvsklsaklqialkillifllllflDavrrvrkvseeeeeaaaklkleaesevqarkFyaQRN 101
                  + lv++ L++  ++ ++lL +Plps  r kl++     kl +  +i+l +l++fl+l f+ +   ++k++ e+++a   ++ e e + q++ F+aQRN
  EFC38000.1   3 SWYLVFLALALLTTLnLVLLFVPLPSFLRTKLVR-----KLDSGKAIFLGLLVVFLVLAFF-CYSDMNKYHLEKATA---KTFELEAQRQMKEFRAQRN 92 
                 5999999998765551667889***998888765.....4445555666666666666665.9********999998...4899999************ PP

       Bap31 102 lYlsGftLfLslvl 115
                 +Y+s +   Lsl+ 
  EFC38000.1  93 FYMSMIGAVLSLIT 106
                 **996666666665 PP

>> MFS_2  MFS/sugar transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   2.1   2.1e-05     0.032     143     243 ..      12     110 ..       3     113 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.1e-05
       MFS_2 143 svlggvlaailafllvlilgglkserkgylifaliialLmllgviivvlgtkervemrkkekteqkeklslleqlkevfrnraflillllfllaalalg 241
                 ++l+++   +l ++l  +l++ k+ rk  +  a++  lL++++v++ + +   +++   +++t+++  l++ +q+ke+  +r f + +++++l + +lg
  EFC38000.1  12 ALLTTLNLVLLFVPLPSFLRT-KLVRKLDSGKAIFLGLLVVFLVLAFFCYSDMNKY-HLEKATAKTFELEAQRQMKEFRAQRNFYMSMIGAVLSLITLG 108
                 566677777788888888887.8888888888888888888777776666665544.4578899999*****************************999 PP

       MFS_2 242 vl 243
                 v+
  EFC38000.1 109 VN 110
                 97 PP

>> ASFV_L11L  African swine fever virus (ASFV) L11L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   2.6   2.7e-05      0.04       7      62 ..      13      74 ..       7      96 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.7e-05
   ASFV_L11L  7 vmapiplvlif..lysyfkiklhkli..tialflgcl..ffilrdfcfppmlwtilqnitlt 62
                +++ + lvl+f  l s+++ kl + +    a+flg l  f++l  fc+  m    l++ t+ 
  EFC38000.1 13 LLTTLNLVLLFvpLPSFLRTKLVRKLdsGKAIFLGLLvvFLVLAFFCYSDMNKYHLEKATAK 74
                456677888774478******9755422479999975448999********99999887764 PP

>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   4.8    0.0006       0.9     149     210 ..       3      94 ..       1     112 [. 0.54

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0006
       MFS_1 149 gWravfyilaivsllafvlfllllpeepperkrkspkeee................................kgtgpaplvpawkallkdpvlw 210
                 +W +vf++la+++ l +vl  l++p +   r +   k ++                                ++t++ ++    k++++++ ++
  EFC38000.1   3 SWYLVFLALALLTTLNLVL--LFVPLPSFLRTKLVRKLDSgkaiflgllvvflvlaffcysdmnkyhlekatAKTFELEAQRQMKEFRAQRNFY 94 
                 6888888888888888665..7777777776666665554455555555555555555555555544443332223333333555555555554 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.4   2.8e-05     0.042      14     108 ..       4     111 ..       1     132 [. 0.71

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.8e-05
    Ndc1_Nup  14 llllsyllslllslsssllwswfplgp...............aglralllflsllpilvlrkaqlhvgprttssrlstllaslfslqtletllvyllSa 97 
                 + l++++l+ll++l+  ll++ +p  +                +l  l++fl+l +     ++++h ++ t+++     +++   ++  + +   +++a
  EFC38000.1   4 WYLVFLALALLTTLNLVLLFVPLP--SflrtklvrkldsgkaIFLGLLVVFLVLAFFCYSDMNKYHLEKATAKTFELEAQRQMKEFRAQRNFYMSMIGA 100
                 455555555555555555555555..566999999999999555558888888899999999*************777777777777777777777777 PP

    Ndc1_Nup  98 llfaevyiwsl 108
                 +l   ++++++
  EFC38000.1 101 VLSLITLGVNM 111
                 76655555544 PP

>> ETRAMP  Malarial early transcribed membrane protein (ETRAMP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   1.8       7.1   1.1e+04       7      17 ..       8      18 ..       4      24 .. 0.55
   2 ?   13.8   0.7   3.1e-05     0.046       8      81 ..      48     115 ..      42     117 .. 0.68
   3 ?   -3.2   0.2       6.1   9.2e+03      33      40 ..     129     136 ..     118     142 .. 0.52

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 7.1
      ETRAMP  7 llffafLlavn 17
                +l +a+L  +n
  EFC38000.1  8 FLALALLTTLN 18
                34444444444 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 3.1e-05
      ETRAMP   8 lffafLlavnlltpeslcdevnkkkekakkaikkiddkiekkkkkkKliiistiatalallvasalGlgiykkk 81 
                 l+++fL++  ++ + +++++ +k    ak    + + ++++  + +++ ++s+i+++l l     lG+ +  kk
  EFC38000.1  48 LLVVFLVLAFFCYSDMNKYHLEK--ATAKTFELEAQRQMKE-FRAQRNFYMSMIGAVLSLIT---LGVNMKEKK 115
                 56777888888888888888875..3333333344444444.4999**********998776...777766665 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 6.1
      ETRAMP  33 ekakkaik 40 
                 e + k++k
  EFC38000.1 129 ESNTKETK 136
                 33333333 PP

>> YrhC  YrhC-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   1.4   9.9e-05      0.15      38      65 ..      40      67 ..       6      70 .. 0.93
   2 ?   -1.1   0.0       1.4   2.1e+03      44      52 ..      95     103 ..      82     119 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 9.9e-05
        YrhC 38 lkksillgaivvfLllaflflrrskkyq 65
                + k+i+lg  vvfL+laf++ +   ky+
  EFC38000.1 40 SGKAIFLGLLVVFLVLAFFCYSDMNKYH 67
                67899****************9999986 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.4
        YrhC  44 lgaivvfLl 52 
                 + +i+++L 
  EFC38000.1  95 MSMIGAVLS 103
                 333333332 PP

>> DUF485  Protein of unknown function, DUF485
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   2.9   6.2e-05     0.093      17      84 ..       5      72 ..       1      76 [. 0.77
   2 ?   -1.8   0.0       2.1   3.1e+03       9      24 ..      87     101 ..      80     108 .. 0.49

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 6.2e-05
      DUF485 17 afpltaiflvvYfgfvllvafapdllatkvgegnitvglllgllqivltfllt.glYvrrAnrefDpla 84
                 ++++a++l+  + +vll+   p++l tk++  ++  g ++ l+++v++ +l+ ++Y+ + + ++++++
  EFC38000.1  5 YLVFLALALLTTLNLVLLFVPLPSFLRTKLV-RKLDSGKAIFLGLLVVFLVLAfFCYSDMNKYHLEKAT 72
                567889999999*******************.6688888888887777776661567766666666655 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2.1
      DUF485   9 Lvrkrrrfafpltaif 24 
                 ++++r+ f + ++ ++
  EFC38000.1  87 FRAQRN-FYMSMIGAV 101
                 444443.444443333 PP

>> DUF898  Bacterial protein of unknown function (DUF898)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   4.1   0.00019      0.28     184     296 ..       5     109 ..       1     117 [. 0.73

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00019
      DUF898 184 wlaavllfllglvlliallaalltevlakeaaatadaskseaellklavllilalvllllallaaayykarifnlvwnnttlegarfksslrardlvll 282
                 +l++++l+ll+++ l++l++ l + +l+++   + d++k       +++l++l+++l+l+++  + + k ++ +++ +  +le  r   ++ra++ + +
  EFC38000.1   5 YLVFLALALLTTLNLVLLFVPLPS-FLRTKLVRKLDSGK-------AIFLGLLVVFLVLAFFCYSDMNKYHLEKATAKTFELEAQRQMKEFRAQRNFYM 95 
                 555566666666666666666544.44455544444443.......78899999999899999999999999999999*****9877778888777777 PP

      DUF898 283 yitnlllllltLGl 296
                  +  ++l l+tLG 
  EFC38000.1  96 SMIGAVLSLITLGV 109
                 77778888999996 PP

>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   1.5      0.93   1.4e+03      13      23 ..       6      16 ..       3      26 .. 0.83
   2 ?   10.1   0.0   0.00064      0.95       5      22 ..      42      59 ..      38      84 .. 0.88
   3 ?    2.2   0.1      0.19   2.8e+02      16      53 ..     100     138 ..      93     144 .] 0.57

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.93
   OAD_gamma 13 vVFvvLilLsl 23
                 VF++L+lL+ 
  EFC38000.1  6 LVFLALALLTT 16
                59******975 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00064
   OAD_gamma  5 lltllGmgvVFvvLilLs 22
                +  +lG++vVF+vL++ +
  EFC38000.1 42 KAIFLGLLVVFLVLAFFC 59
                56789**********976 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.19
   OAD_gamma  16 vvLilLslvisl.fskiikkkakkkkkkakaaaaaaaaa 53 
                 +vL l++l ++   +kii +++k + k+ +++++++++ 
  EFC38000.1 100 AVLSLITLGVNMkEKKIIDLEDKVQLKQRESNTKETKEV 138
                 566666666665456777777666666655555555443 PP

>> DUF4131  Domain of unknown function (DUF4131)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   7.3    0.0026       3.9       4      53 ..       3      64 ..       2     132 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0026
     DUF4131  4 plalvllalllllllllllllrr.........rprrrv.......llllllllllallgfalrapq 53
                +++lv+lal+ll++l l+ll+                +       ++l ll+ +l+l++f+++  +
  EFC38000.1  3 SWYLVFLALALLTTLNLVLLFVPlpsflrtklV----RkldsgkaIFLGLLVVFLVLAFFCYSDMN 64
                578888888888888888888556666644440....26666665888888888888888876654 PP

>> EI24  Etoposide-induced protein 2.4 (EI24)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   9.6     0.017        25     111     169 ..      47     107 ..       1     108 [. 0.69

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.017
                 TTHHH....HHHHH..HHHHHHHHHHHHHHHHH.-HHHHHHHHHCTHHHHHHHHHHHHHHTT CS
        EI24 111 Pvvglilsplllsw..ltayfycfeyldlaagr.sleerrallerrrayflgfGllvsllll 169
                  ++ ++l+++++++  ++ y +  ++++  +++   +++++++ +r++y+  +G+++sl++l
  EFC38000.1  47 GLLVVFLVLAFFCYsdMNKY-HLEKATAKTFELeAQRQMKEFRAQRNFYMSMIGAVLSLITL 107
                 33344444444444335555.5666777777778888888888899999999**99999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (144 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1475  (0.0822689); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 938.71
//
Query:       EFC38001.1  [L=178]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       356  (0.0198561); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 1207.29
//
Query:       EFC38002.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      1e-27   96.9  43.5    1.4e-27   96.4  39.0    2.0  2  Snf7             Snf7
  ------ inclusion threshold ------
          1    9.1   5.0        8.1    6.2   4.9    2.1  1  Sulfotransfer_4  Sulfotransferase domain
          1    7.9  20.8        1.2    7.7  20.8    1.0  1  Peptidase_S46    Peptidase S46
        2.1    7.3  11.7          3    6.9  11.7    1.3  1  hDGE_amylase     Glycogen debranching enzyme, glucanotransfer
        2.4    8.0  11.2       0.87    9.4   1.1    2.2  2  DUF5352          Family of unknown function (DUF5352)
        3.7    7.5   6.7        3.9    7.5   2.9    2.3  2  T2SSF            Type II secretion system (T2SS), protein F


Domain annotation for each model (and alignments):
>> Snf7  Snf7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   96.4  39.0   4.7e-31   1.4e-27       1     162 [.      16     173 ..      16     181 .. 0.96
   2 ?    3.3   0.2     0.018        54      88     108 ..     180     200 ..     175     211 .. 0.81

  Alignments for each domain:
  == domain 1  score: 96.4 bits;  conditional E-value: 4.7e-31
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTT-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        Snf7   1 eairsLrkaerkldkkqeslekkikkleaelkklakkgnkdralllLKqkkryekqldqldnqlanleqvslaienlksnkevlnamkqgakamkamnk 99 
                 e++++Lr  +r++d++  +l+++++kl+ ++k+  +kg++ +a+ l+Kq+++++kq +++ ++++++++v++++ +++++ +++ a k + ++m++mn+
  EFC38002.1  16 EQKKELRSGTRDMDREANKLKTEEQKLQIQVKRALEKGDQTTAKTLAKQIVNLRKQQERMGKMKQTMNTVQFKATSMQAQDKMVGAIKATGNVMQKMNQ 114
                 57899********************************************************************************************** PP

                 CTCCHHHHHHHHHHHHHHHHHTCHHHHHHHHHTT-GGTTHHHHHHHHHHHHHHHHHCSH.HHH CS
        Snf7 100 kvdidkidklmdeiedqmekaeeisEalsrslddadeedEeeleaeLdaLeqelgdeelldes 162
                 ++++++ +k+m+e+++++ek ++++E+++++ldd+ + +Eee+++ ++++ +e+g e     s
  EFC38002.1 115 QMNLQDMQKTMMEFQQAQEKTSMTEEMMDDALDDMFQDEEEEVDEAMEQIYDEIGLEV----S 173
                 ***********************************9999**************99886....4 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.018
                 HHHHHHHHHHHHCTCCHHHHH CS
        Snf7  88 kqgakamkamnkkvdidkidk 108
                 k+g +a+ka +k+ d+d+i++
  EFC38002.1 180 KTGSSALKASRKEKDLDEIED 200
                 8999**************986 PP

>> Sulfotransfer_4  Sulfotransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   4.9    0.0027       8.1     107     166 ..     109     167 ..      38     180 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0027
  Sulfotransfer_4 107 mkktllalrsetlsrllalldpllellaklvellralvrrlfgagsdaedeeaakeayee 166
                      m+k+ ++++ + ++++++ +++ +e ++   e+++++++++f+++ ++e++ea++++y+e
       EFC38002.1 109 MQKMNQQMNLQDMQKTMMEFQQAQEKTSMTEEMMDDALDDMFQDE-EEEVDEAMEQIYDE 167
                      555555666555666666666666666666677777777777764.56777777777766 PP

>> Peptidase_S46  Peptidase S46
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7  20.8   0.00039       1.2     284     436 ..      10     162 ..       3     197 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00039
                    HHHHHHH-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHCT-H.HHHTTHHHHHHHHHHHHHHHHHHHHHHHHHTTT CS
  Peptidase_S46 284 lkeemkkdpeirikyasklagleNylKnliGmlealkkkkvlekkqaeeaalrawlkkdpekkekygkalselealvkekrklaersalleeaess 379
                     +e  k++++  +  + ++++ +N+lK  + +l+   k+++ +  q+  ++l++ + +  +++e++gk+ +++++++ + + +++++ ++++++++
     EFC38002.1  10 NQELLKEQKKELRSGTRDMDREANKLKTEEQKLQIQVKRALEKGDQTTAKTLAKQIVNLRKQQERMGKMKQTMNTVQFKATSMQAQDKMVGAIKAT 105
                    4455566666777778899999************999****99***************************************************** PP

                    TSHHHHHHHHHHHHHHHHH....HH-HHHHHHHHHHHHHHCHHHHCS--HHHHHHHH CS
  Peptidase_S46 380 gsellslarklvrlaeerekpdaereeeyqeralealekeleridkdldaevdkavl 436
                    g  + ++ ++++  + +++  + ++ +e++  + e++ ++l+++++d ++evd+a+ 
     EFC38002.1 106 GNVMQKMNQQMNLQDMQKTMMEFQQAQEKTSMTEEMMDDALDDMFQDEEEEVDEAME 162
                    *88888888888888888899999999999999999999999999999999999875 PP

>> hDGE_amylase  Glycogen debranching enzyme, glucanotransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9  11.7   0.00099         3     181     300 ..      44     168 ..       5     188 .. 0.53

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00099
                   --CHHHHHHHHHSTTSS.----SS---..-TT..SHHHHHHHHHHHS............-SSTTS--STT---B-HHHHHHHHHHHT-SS.TTT... CS
  hDGE_amylase 181 vdvekeveelkealees.ekkeklelkeelkea.slkeeaklvkeka............lkeakkllerfsakidlevaaallkalleeekkeeeee 263
                   ++v++++e+  ++++++ +k+  ++l+++++++ ++k+++++v+ ka            +k + +++++++++++l+ +        ++++ e +++
    EFC38002.1  44 IQVKRALEKGDQTTAKTlAKQI-VNLRKQQERMgKMKQTMNTVQFKAtsmqaqdkmvgaIKATGNVMQKMNQQMNLQDM--------QKTMMEFQQA 131
                   5555555555555544422222.22222222223455555544444433111112122222223333333333333332........3333444445 PP

                   .THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  hDGE_amylase 264 eevaeklkkildelNlelykeldedvkaileqllnri 300
                   +e ++ +++++d+   +++++ +e+v++++eq++++i
    EFC38002.1 132 QEKTSMTEEMMDDALDDMFQDEEEEVDEAMEQIYDEI 168
                   5555555666666666666666666666666666665 PP

>> DUF5352  Family of unknown function (DUF5352)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   1.1   0.00029      0.87      66     140 ..      14      94 ..       2      99 .. 0.67
   2 ?    3.2   3.4     0.023        69      36      94 ..     103     161 ..      96     172 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00029
     DUF5352  66 kkasklaelkkvkaddedpnaesCvDkvLRadvaeavkkatdnsCkgivnalv...lnLnRPG...WainCvkfnelaldd 140
                  k++k+   + +++ d++ n+ +  +++L  +v+ a++k ++++ k + + +v    +  R G    ++n v+f+++++++
  EFC38002.1  14 LKEQKKELRSGTRDMDREANKLKTEEQKLQIQVKRALEKGDQTTAKTLAKQIVnlrKQQERMGkmkQTMNTVQFKATSMQA 94 
                 333333334445566777788889999*************99999999887762223456666333578999998888865 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.023
     DUF5352  36 lntttllknrkvllsgtnatkllvkaeksskkasklaelkkvkaddedpnaesCvDkvL 94 
                 + t+ +++++ ++++ + ++k++++++++++k+s + e+   + dd  +++e  vD+ +
  EFC38002.1 103 KATGNVMQKMNQQMNLQDMQKTMMEFQQAQEKTSMTEEMMDDALDDMFQDEEEEVDEAM 161
                 66888999999999999999999999999998888888887777777777777777765 PP

>> T2SSF  Type II secretion system (T2SS), protein F
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.2     0.092   2.7e+02      47      82 ..      45      83 ..      11      98 .. 0.62
   2 ?    7.5   2.9    0.0013       3.9      37     103 ..      97     164 ..      89     166 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.092
                SHHHHHC...T-TT.TS-HHHHHHHHHHHHHT-HHHHHH CS
       T2SSF 47 slseale...rtpssefpelvvqlirageeggnLaevLe 82
                 +++ale   +t+ + +++ +v+l  + e+ g++ ++++
  EFC38002.1 45 QVKRALEkgdQTTAKTLAKQIVNLRKQQERMGKMKQTMN 83
                444555555544444455566666666666666555554 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0013
                 HHHHHHHTTSSHHHHHC.T-TT.TS-HHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       T2SSF  37 riarrlraGgslseale.rtpssefpelvvqlirageeggnLaevLerlaeyleeerelrrkllaall 103
                 +++  ++a g++ + +  +++  ++ ++++ + +a e+++  +e+++++ +++ +++e + +++ + +
  EFC38002.1  97 KMVGAIKATGNVMQKMNqQMNLQDMQKTMMEFQQAQEKTSMTEEMMDDALDDMFQDEEEEVDEAMEQI 164
                 5666677777777777787778899*********************************9999887766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4760  (0.265492); expected 358.6 (0.02)
Passed bias filter:                      684  (0.0381505); expected 358.6 (0.02)
Passed Vit filter:                       100  (0.00557756); expected 17.9 (0.001)
Passed Fwd filter:                        29  (0.00161749); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.88u 0.37s 00:00:01.25 Elapsed: 00:00:00.54
# Mc/sec: 1189.85
//
Query:       EFC38003.1  [L=445]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.7e-10   40.0   4.2    7.2e-10   39.1   4.2    1.5  1  DUF1771    Domain of unknown function (DUF1771)
    9.8e-10   38.7   0.0    2.3e-09   37.5   0.0    1.6  1  Smr        Smr domain
    5.8e-07   29.2   0.1    1.5e-06   27.9   0.1    1.7  1  KH_1       KH domain
    0.00036   20.2   4.8    0.00071   19.2   4.8    1.5  1  PspA_IM30  PspA/IM30 family
     0.0017   18.2   0.0     0.0017   18.2   0.0    2.5  3  KH_2       KH domain
  ------ inclusion threshold ------
       0.17   12.9   0.0       0.17   12.9   0.0    2.7  3  DUF4834    Domain of unknown function (DUF4834)
       0.17   12.4   0.6        0.5   10.9   0.2    2.1  1  PhoU       PhoU domain
       0.88    9.9   4.9        1.8    8.9   3.2    2.3  2  DUF2935    Domain of unknown function (DUF2935)
       0.97    9.7   5.3       0.41   10.9   2.1    2.1  2  SMBP       Small metal-binding protein
        6.5    7.1  15.9        6.4    7.1  10.8    3.0  2  OmpH       Outer membrane protein (OmpH-like)


Domain annotation for each model (and alignments):
>> DUF1771  Domain of unknown function (DUF1771)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1   4.2     4e-13   7.2e-10       4      64 .]     304     364 ..     301     364 .. 0.91

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 4e-13
     DUF1771   4 lRaeAdeharkrnelfekAaeAyrrGdgaaAkelseqGkehgekmeeanreAaeaIfeerN 64 
                 l ++ +e+a+ +++ fe A++A+++Gd++ A++ls++Gk+++  m+++ +e+a+ ++++ N
  EFC38003.1 304 LEKKIQEQAQIMASSFENAKKAFEEGDKGLASQLSNEGKHAQSLMKQYQEESANVMYDHLN 364
                 55777899999*******************************************9998866 PP

>> Smr  Smr domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.5   0.0   1.3e-12   2.3e-09       1      57 [.     372     430 ..     372     441 .. 0.89

  Alignments for each domain:
  == domain 1  score: 37.5 bits;  conditional E-value: 1.3e-12
                 EE-TT--HHHHHHHHHHHHHHHHHTT-SEEEEE--STTSTT..HCHHHHHHHHHHHCST CS
         Smr   1 lDLhglrraealnvletfldaasakglrsvevihGkGahag..vgvLrpavmgwLagke 57 
                 +DLhg  ++ a+n l++ +++  ++ ++++++i G G+h++   ++++pav  +L++++
  EFC38003.1 372 IDLHGQYVDAAMNFLKQRIEKLKSQSINQLTIIYGAGNHSDasGPKIKPAVLTYLKENN 430
                 8**************************************66669************983 PP

>> KH_1  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   0.1   8.6e-10   1.5e-06       7      53 ..     216     259 ..     210     269 .. 0.84

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 8.6e-10
                 GGGHHHHHHTGGGHHHHHHHHHHT-EEEEESSTT...T.-EEEEEES CS
        KH_1   7 PsslvgriIGkgGsnIkeIreetgakIkvpksedegsderevtisGs 53 
                 Ps+   ++IG +G++I++I++et+ kI++ +++d   d++ vti+ +
  EFC38003.1 216 PSHISKYLIGQKGATINKIKDETQSKIDMSPIDD---DSTLVTITAN 259
                 6777889*********************876555...7999999864 PP

>> PspA_IM30  PspA/IM30 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   4.8     4e-07   0.00071      43     110 ..     291     358 ..     282     397 .. 0.90

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 4e-07
   PspA_IM30  43 rqalaqviarqkqlerkleeqkeqakklekkAkaALtkgeeeLArealaeikslekqaealetqlaqq 110
                  + l + ++  k+le+k++eq++ +++  ++Ak+A+++g+  LA  +  e k +++ +++++++ a++
  EFC38003.1 291 VEHLTESMKLFKELEKKIQEQAQIMASSFENAKKAFEEGDKGLASQLSNEGKHAQSLMKQYQEESANV 358
                 567788999*****************************************************987764 PP

>> KH_2  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.1       3.9   7.1e+03      11      20 ..      86      95 ..      79     111 .. 0.52
   2 !   18.2   0.0   9.3e-07    0.0017      14      64 ..     197     245 ..     186     281 .. 0.82
   3 ?   -4.1   0.1       8.3   1.5e+04      45      55 ..     388     398 ..     386     403 .. 0.54

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.9
                ECETEEEEEE CS
        KH_2 11 kkagvskveI 20
                +k ++ +v++
  EFC38003.1 86 EKVEKPSVVV 95
                3333333333 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 9.3e-07
                 T....EEEEEEECCSCEEEEEEEESCH.HHHHTGGGHHHHHHHHHHHHHHHHHHTT CS
        KH_2  14 g....vskveIertanrviiviresqp.givIGkgGsnikkigkelrkdieklegk 64 
                 +    vs++++    ++  +vi+ s+  + +IG++G++i+ki+ e + +i+   ++
  EFC38003.1 197 QerefVSNLDV----EKSSFVIKPSHIsKYLIGQKGATINKIKDETQSKID---MS 245
                 23357999999....9999*******7479*******************96...55 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 8.3
                 HHHHHHHHHHH CS
        KH_2  45 snikkigkelr 55 
                 ++i+k++++  
  EFC38003.1 388 QRIEKLKSQSI 398
                 45555555443 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   9.2e-05      0.17      10      73 ..       4      68 ..       1      82 [. 0.48
   2 ?   -4.1   0.2        10   1.8e+04      85      94 ..     283     292 ..     279     293 .. 0.88
   3 ?    0.4   0.7      0.75   1.3e+03      42      94 ..     329     380 ..     297     380 .. 0.46

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 9.2e-05
     DUF4834 10 fiiailviglsilsvilrtvfglgsrkkss.ksaqkqfgnstnsnqqksqsrsetkeegeiieee 73
                +i+++++ g+ il + l ++f+ +  ++s  + a+k+  ++ + n++k++ +++t+++ ++++++
  EFC38003.1  4 LILILFLAGFPILTKYLVAIFSPSTTSSSAsSGAAKKVDENSSANNKKETPKNTTTTTATAVSSS 68
                67788888888888888888884443333312223333333333333333333333333333332 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 10
     DUF4834  85 FekdeGEYVd 94 
                 F+k+e  +V+
  EFC38003.1 283 FDKNENQFVE 292
                 9999999998 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.75
     DUF4834  42 aqkqfgnstnsnqqksq..srsetkeegeiieeersekeakrkkiFekdeGEYVd 94 
                  +k+ +++ +++ ++ q   +++++e+ ++++++ +++ +++  i  +  G YVd
  EFC38003.1 329 GDKGLASQLSNEGKHAQslMKQYQEESANVMYDHLNKD-RPETEI--DLHGQYVD 380
                 23333333333333333123333444444444444433.222244..45566665 PP

>> PhoU  PhoU domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.2   0.00028       0.5       3      54 ..     310     362 ..     308     387 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00028
                 HHHHHHHHHHHHHHHHHHCT-HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HH CS
        PhoU   3 rmaeiveemlddalealeekdtelarevierddeidrlekeierslleal.ak 54 
                 + a+i  + +++a +a+ee+d+ la ++ ++ + +  l k+ +++  + +  +
  EFC38003.1 310 EQAQIMASSFENAKKAFEEGDKGLASQLSNEGKHAQSLMKQYQEESANVMyDH 362
                 56889999********************9999999999888888887777555 PP

>> DUF2935  Domain of unknown function (DUF2935)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0        10   1.8e+04      93     117 ..     138     162 ..     135     163 .. 0.67
   2 ?    8.9   3.2     0.001       1.8      14      59 ..     290     359 ..     285     407 .. 0.68

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 10
     DUF2935  93 vlscklfsiiypllidHilrEaeyY 117
                 + +++    ++p+++  +++E++++
  EFC38003.1 138 ISTNEFVEETTPVVVSNTVQESNEF 162
                 5566666677788888888887777 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.001
     DUF2935  14 mkeHalfiealldpkekdlikeakefkkeFekllaeavelseglv........................r 59 
                   eH ++  +l+++ ek++ ++a+ ++ +Fe+  +  +e  +gl                         +
  EFC38003.1 290 FVEHLTESMKLFKELEKKIQEQAQIMASSFENAKKAFEEGDKGLAsqlsnegkhaqslmkqyqeesanvM 359
                 569*****************************************96666666666666666555555553 PP

>> SMBP  Small metal-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1         3   5.3e+03      47      47 ..      55      55 ..      19      98 .. 0.58
   2 ?   10.9   2.1   0.00023      0.41      45     110 ..     286     350 ..     283     363 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 3
                H CS
        SMBP 47 k 47
                k
  EFC38003.1 55 K 55
                1 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00023
                 -HHHHHHHHHHHHHHHHHH...-------HHHHHHHHHHHHHHHHHCT-HHHHHHHHHHHHHHHHH CS
        SMBP  45 hakalveHaeealkhakaaaekakeeekehldegikhLeeAIkhgkaghadvAtkaaeeAlkhlka 110
                 + ++ veH +e++k  k+  ek+ +e+++ +  +++  ++A ++g++g a++ +++ + A + +k+
  EFC38003.1 286 NENQFVEHLTESMKLFKEL-EKKIQEQAQIMASSFENAKKAFEEGDKGLASQLSNEGKHAQSLMKQ 350
                 5678999******999999.999999999999**************99998877777777776666 PP

>> OmpH  Outer membrane protein (OmpH-like)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.2       1.2   2.2e+03      89     111 ..      79     101 ..      38     119 .. 0.73
   2 ?    7.1  10.8    0.0036       6.4      11      64 ..     295     371 ..     263     433 .. 0.51

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHHHHHHHHHHTT- CS
        OmpH  89 ellkpildkinkaikevakekgy 111
                 + +kp+++k++k    va+e + 
  EFC38003.1  79 QKTKPVIEKVEKPSVVVAAETKP 101
                 45788899998888888877653 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0036
                 HHHSHHHHHHHHHHHHHH..................HHHHHHHHHHHHHHHHHHHHHHHHTTTS......-HHHHHH CS
        OmpH  11 leespegkaaqeqlekkf..................kklqaeleakekelqklqeelqkkakkl.e....keekeqe 64 
                  e+++ +k+ ++++++++                  k l+ +l +++k  q+l++++q+++++       k + e e
  EFC38003.1 295 TESMKLFKELEKKIQEQAqimassfenakkafeegdKGLASQLSNEGKHAQSLMKQYQEESANVmYdhlnKDRPETE 371
                 44444444444444444433333344444444444444444444444444444444443333322244433333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2096  (0.116906); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.72u 0.34s 00:00:01.06 Elapsed: 00:00:00.52
# Mc/sec: 2560.58
//
Query:       EFC38004.1  [L=514]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0027   17.8   2.2     0.0066   16.5   2.2    1.6  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   2.2   3.7e-07    0.0066      16      39 ..     100     122 ..      97     123 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3.7e-07
                 SSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  16 kkPaCsnCkklnleCtfysesskr 39 
                  kP+C +C++++ +C+ y+es+++
  EFC38004.1 100 TKPSCDRCVSRGIPCE-YRESKRK 122
                 79**************.****998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1279  (0.0713369); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.47
# Mc/sec: 3281.35
//
Query:       EFC38005.1  [L=357]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-60  204.4   0.8    1.5e-40  139.1   0.1    2.9  2  Actin     Actin
  ------ inclusion threshold ------
      0.014   14.2   0.0       0.68    8.7   0.0    2.2  2  MreB_Mbl  MreB/Mbl protein


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.1   0.1   1.7e-44   1.5e-40       4     288 ..       3     260 ..       1     266 [. 0.90
   2 !   60.9   0.0     9e-21   8.1e-17     328     406 ..     283     356 ..     279     357 .] 0.93

  Alignments for each domain:
  == domain 1  score: 139.1 bits;  conditional E-value: 1.7e-44
       Actin   4 vsavVlDnGssttraGyagedaPkavipslvgkprgrkveaklyvgde..altkrpelevrspvedGvvedwdaveelwehvlkeelkvd..peehpll 98 
                  +++V+++Gs +tr+G ag+++P++++ +lvg+ ++     k  vg++  +l  ++e+e+++pv++G++ +w ++e +++h + ++l  +   +++++l
  EFC38005.1   3 RPVIVFEMGSLNTRVGMAGDETPEHIFQTLVGRLNNG----KEIVGEKvdELYGKEEMELTKPVKEGMIDNWQDAELIFHHGMSKQLGEKsdWSDYSIL 97 
                 579*********************************9....56788876555579*******************************86662269***** PP

       Actin  99 ltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtpr 197
                 l + p++ +++r k  Ei++E+++  +l + ++ v s+fa+g + + v+ sG++ t v  +++G  + + + +++ +G++Lt+ + e ++ +       
  EFC38005.1  98 LFDHPFTEHSDRMKSSEIILESLGLSGLNFIQNCVASSFAHGETKATVLTSGDELTYVLSIHEGRLIPHTTEKYSKAGRDLTQVMLEGMEFS------- 189
                 ************************************************************************************99999985....... PP

       Actin 198 ylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeekss.sspeksYeLPDgs.eiklgeeRfkvpEiLFdpsl 288
                                         ++y+++ +++  +++Ke++   +++ +  +++    +  +++eLPDg+ + ++ + R  ++E+LF+ ++
  EFC38005.1 190 ----------------------DSSNYDEYTRMKFARMAKETLAHLARSGKSVSTTRFqLPELTNFELPDGNtVRVFASTRLACTESLFQDEE 260
                 ......................2569********************9999863333331444567*******6678999**********9876 PP

  == domain 2  score: 60.9 bits;  conditional E-value: 9e-21
       Actin 328 ivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGssvverkc 406
                  ++ GGn+ll+g+ +Rl++e+++ ++   +v +  +     +saW+GGSiLAs  +f+   +sk+EYeE+G++v e+k 
  EFC38005.1 283 LILNGGNTLLEGFDKRLDAEVTRAFHRIGNVSVLPSI---ENSAWVGGSILASFTQFS--LISKREYEEMGKQVLEKKI 356
                 799********************99999999999887...89************9996..89***************97 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0   7.5e-05      0.68      41      96 ..      42      96 ..      10     116 .. 0.85
   2 ?    3.3   0.0    0.0033        30     276     297 ..     282     303 ..     272     313 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 7.5e-05
                EESHHHHTTTTS-GTTEEEE-SEETTEESSHHHHHHHHHHHHHHHHT.SS-SS--EE CS
    MreB_Mbl 41 avGeeAkkmlgktpgnikavrPlkdGviadlevaeellkyfikkvkk.kkslskprv 96
                 vGe+  ++ gk  ++++ ++P+k+G+i + + ae ++++ ++k    k+ +s  ++
  EFC38005.1 42 IVGEKVDELYGK--EEMELTKPVKEGMIDNWQDAELIFHHGMSKQLGeKSDWSDYSI 96
                589999999996..789999*******************999887663555555555 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.0033
                 -EEEESGGGGSBTHHHHHHHHH CS
    MreB_Mbl 276 givltGGgallkgldkllseet 297
                 +++l GG +ll+g+dk l  e+
  EFC38005.1 282 TLILNGGNTLLEGFDKRLDAEV 303
                 689**************99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (357 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       293  (0.0163422); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 2347.21
//
Query:       EFC38006.1  [L=290]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        5.4    6.6  13.7         11    5.5  13.7    1.5  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5  13.7   0.00061        11      17      92 ..     110     196 ..      91     202 .. 0.47

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.00061
       SR-25  17 ekkrkksskdssrsssasksqsrkassa.sekee.......erskekkkkkrrrssssssssssssssssssssssssdd...rkkr 92 
                 ++k+ kss  s+++s + +++ + +++  +++++        +++e +  krr  +s+s  ss  s s+ ss s ss +    +kkr
  EFC38006.1 110 DRKQTKSSTLSNSNSNSMPNTLNTTCKFvQDYSNthysnysIDQHETNPLKRRLCASTSPYSSNESYSAVSSHSASSTSPtltQKKR 196
                 333444444333333333333222222202222244566653444455556666666666666655554444333333332423333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (290 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1235  (0.0688828); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1948.53
//
Query:       EFC38007.1  [L=281]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.015   15.5   0.9      0.049   13.8   0.9    1.9  1  Toxin_8    Alpha conotoxin precursor
      0.041   13.1   0.0      0.067   12.4   0.0    1.4  1  Ion_trans  Ion transport protein


Domain annotation for each model (and alignments):
>> Toxin_8  Alpha conotoxin precursor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.9   5.5e-06     0.049      32      50 .]     141     159 ..     134     159 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 5.5e-06
     Toxin_8  32 rkeCCsnPaCrvsnpelCg 50 
                 + +CCs+P ++  n+elCg
  EFC38007.1 141 QSGCCSYPTTKTGNSELCG 159
                 459***************8 PP

>> Ion_trans  Ion transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   7.5e-06     0.067     133     228 ..       9     280 ..       1     280 [. 0.72

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 7.5e-06
                 HHHHHHHHHHHHHHHHHHHHTTSCCCC........................................................................ CS
   Ion_trans 133 vlllllvvlfifaligvqlfkgklrek........................................................................ 159
                 +l+l++ +++i ++ g+ ++    ++                                                                         
  EFC38007.1   9 FLFLCIGMFMISSVSGHARW----KYPtprtsdsglksypcggveffgngqpvtilqpgkqilqfeetishtgapfrialsinsdsnyekyilidhiph 103
                 44455555555555555555....222566777788888888888888888888888888888888888888888888888888888888888888888 PP

                 .................................................................................CC......SCCSTSSSTT CS
   Ion_trans 160 .................................................................................ne......caktwenpnn 171
                                                                                                  +       ++ +w+++ +
  EFC38007.1 104 ndqsdssslkvyqylvdipnikcqkcsisltnpmtdkqsgccsypttktgnselcgsvyhscaniqingtvelsnfkynytGPcgdytqESSSWTKQSD 202
                 888888888888888888888888888888888888888888888888887777777777777777776666666655555005555557889999999 PP

                 TSSSSSSHHHHHH........HHHHHHTTSSHHHHHHHHHHHS.............HHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans 172 gntnFdnfftall........wlfrlmttegwgdilyatldek.............skvaliyfvifiilgsflllNl 228
                 + ++ dn+ t ++        + f + + e ++++ ++ ++++             ++ +++ fv +++++ f+llN+
  EFC38007.1 203 DSWKLDNMYTGFYvpptsqqcSRFKISCNETYPEVSNNSQNGNsnnepkttisnciPSSCVAPFVFYFMIVLFVLLNI 280
                 9999999777776222111113455777777777777777777*********************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (281 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1704.24
//
Query:       EFC38008.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 769.71
//
Query:       EFC38009.1  [L=483]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.6e-13   48.3   4.7    1.2e-11   44.4   4.7    2.5  1  G-alpha   G-protein alpha subunit
  ------ inclusion threshold ------
      0.067   13.3   0.3       0.59   10.2   0.0    2.5  3  MMR_HSR1  50S ribosome-binding GTPase


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.4   4.7   1.3e-15   1.2e-11      24     342 ..      23     426 ..      12     436 .. 0.67

  Alignments for each domain:
  == domain 1  score: 44.4 bits;  conditional E-value: 1.3e-15
                 EEEEEEESTTSSHHHHHHHHH......HHCS--........................--HHHH.HC.CHHHHHHHHHHHHHHHHHHHHHTT.......H CS
     G-alpha  24 vkllllGqseSGKsTilkqlk......llykkg........................fseeel.at.wraviqlnivrsiktilealesleselsesfe 90 
                 + ++++G+  SGKsT+l+ ++      ll +k+                         +e+ +  + ++  + +++++ +++il++l+  ++++  s++
  EFC38009.1  23 YGVVIVGSPYSGKSTLLRLIRkadlldLLTGKAkpssssslgssgpitslitgfpipSNESTSyGYqFQLKVLQTCLKTMQLILNELKLNQHNH--SVH 119
                 5678999999******999997765543333336767777766666666666666542222222223555888999999999999998855555..554 PP

                 HHC-SS-SCCCS-HCHHHH.........................HHCCHHC..........-HCHHHHHHHHCCSHHHHHHHCCGCCTT-........- CS
     G-alpha  91 lqelkerldplkkveasliaklssateee...............qeiefnp..........raevgedikaLwndpgiqelyerrnkikl........e 156
                   +   ++++++ +++  ++                        ++    +           + +++++ ++w  p+i+++y+r  +           +
  EFC38009.1 120 GYSSASNASEMLGSSSLGSE--------YadikntfgrqveiieEN----SiwdslldthrVNGMIDNLSTVWMIPAIKSTYQRLLDCGYftpffqfsN 206
                 44444444444444333221........011112234323333322....0222355544444566688999999999999998844432233344331 PP

                 TTHHHHHCTHHHHCSTT---.................................................................-CHHHHCS-----S CS
     G-alpha 157 dnaeyFlddleritspdYlp.................................................................tddDilkarlktvG 190
                                 +Y                                                                   +d++i   r    G
  EFC38009.1 207 ---------------DKYGYaqsnpnirgeniadlldnlsfimkrpitiqgsekdmkngsikiveyllktyledrffapdisnpqNDKHITENR--EQG 288
                 ...............2222222333333444444444444444555666777777778888888888888888888888888877778888888..999 PP

                 EEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS CS
     G-alpha 191 isetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg 289
                 ++  kf+ + k+e r+++++ +           +++ +++Flv+ls++d+   ++++++ +++ l+ F + ++ +     + +L+++K Di+++++++g
  EFC38009.1 289 VKYGKFSWGIKTEPRVYNLAQSYH--------TKSAPVVLFLVPLSDIDK--KKSKRTTFVTDYLEKFYTTLTDPGT---QKVLVFTKADIFSKRISSG 374
                 999999999999999999994443........378999************..6677999999999999999999865...667*************999 PP

                 ..-GGGCCTT--H.CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHH CS
     G-alpha 290 ..klskyfpsyegrkndlesvlkylrnkFeeihkeksnnrrkiythftsatdtke 342
                   +++++fp++ g++ d   v++ + +kF  + +++   ++++ +++++++d +e
  EFC38009.1 375 siDVQSIFPDFVGNSTDPLRVFEHFFSKFWILCRKY---HEVVPYYVVNLVDMEE 426
                 899999**************************9965...5567777888888765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   6.6e-05      0.59       2      21 ..      25      44 ..      24      60 .. 0.86
   2 ?   -1.2   0.0      0.24   2.1e+03      66     102 ..     307     344 ..     296     363 .. 0.55
   3 ?   -1.6   0.0       0.3   2.7e+03       6      24 ..     438     456 ..     437     478 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 6.6e-05
                EEEEESTTSSHHHHHHHHHT CS
    MMR_HSR1  2 vaivGrpNvGKStLinaltg 21
                v+ivG p +GKStL++ + +
  EFC38009.1 25 VVIVGSPYSGKSTLLRLIRK 44
                89*************98765 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.24
                 HHHHHHHHHCTSEEEEEEETT...TTCSHHHHHHHHHHHH CS
    MMR_HSR1  66 lgkaflaleeadlillvvdas...eeklkpldeeleelle 102
                 l+++++  ++a ++l++v +s   ++  ++    + ++le
  EFC38009.1 307 LAQSYH-TKSAPVVLFLVPLSdidKK-KSKRTTFVTDYLE 344
                 555666.3557899999987744322.2223344444444 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.3
                 ESTTSSHHHHHHHHHTSTE CS
    MMR_HSR1   6 GrpNvGKStLinaltgeka 24 
                 G p  GKS L +++++++ 
  EFC38009.1 438 GSPYHGKSFLSKQILKATD 456
                 6777899999999998643 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.26s 00:00:00.86 Elapsed: 00:00:00.44
# Mc/sec: 3324.79
//
Query:       EFC38010.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-35  119.2  21.9    1.7e-08   34.9   1.1    7.5  6  Sel1      Sel1 repeat
  ------ inclusion threshold ------
      0.053   14.2   5.5         49    4.9   0.1    4.5  4  TPR_6     Tetratricopeptide repeat
        0.1   12.7   1.0         23    5.2   0.0    2.9  2  MIT       MIT (microtubule interacting and transport) domain
       0.15   11.9   9.1        8.5    6.4   0.1    4.9  5  TPR_1     Tetratricopeptide repeat
       0.57   10.5   7.3        9.7    6.7   0.8    4.3  3  TPR_8     Tetratricopeptide repeat
          7    7.0   8.3         20    5.6   0.6    3.9  4  TPR_2     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   1.1   5.6e-12   1.7e-08       1      38 []      16      52 ..      16      52 .. 0.95
   2 ?    4.7   1.5     0.017        52       2      18 ..      54      68 ..      53      78 .. 0.71
   3 !   32.2   0.9   3.8e-11   1.1e-07       1      38 []      79     114 ..      79     114 .. 0.97
   4 !   13.8   0.0   2.5e-05     0.073       5      33 ..     119     145 ..     116     148 .. 0.92
   5 !   34.1   0.1   9.5e-12   2.8e-08       1      38 []     184     219 ..     184     219 .. 0.93
   6 !    6.2   0.0    0.0058        17       2      33 ..     221     250 ..     220     253 .. 0.87

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 5.6e-12
        Sel1  1 aeAmyrLGmfylylnGl.gvpkDpekAiewyekAAeqGd 38
                a+A+y+LG  +++++G  gv++D  +A++wy kAA qG+
  EFC38010.1 16 ADAQYNLG--LCFDEGSdGVKQDCALAMHWYMKAALQGH 52
                68******..*******66*******************9 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.017
        Sel1  2 eAmyrLGmfylylnGlg 18
                +A+y++G  +l+++G+g
  EFC38010.1 54 DAQYNVG--LLFEEGRG 68
                7888888..77788875 PP

  == domain 3  score: 32.2 bits;  conditional E-value: 3.8e-11
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a+A+++ G   ly++G+gv k +ekA+ewy kA eqGd
  EFC38010.1  79 AHAQFNIG--WLYDEGKGVQKSYEKALEWYMKASEQGD 114
                 68******..***************************7 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 2.5e-05
        Sel1   5 yrLGmfylylnGlgvpkDpekAiewyekA 33 
                 y+ G+f   ++G+ v+ ++  A++w+ek+
  EFC38010.1 119 YKIGTFF--EKGKVVKENVMMAMQWFEKS 145
                 9***999..******************96 PP

  == domain 5  score: 34.1 bits;  conditional E-value: 9.5e-12
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 ++A y+LG fy  ++G  v++D++kA+e+y kAA+++d
  EFC38010.1 184 SDAIYNLGIFY--EFGIHVKQDYKKAFELYLKAAKRDD 219
                 689*****777..**********************986 PP

  == domain 6  score: 6.2 bits;  conditional E-value: 0.0058
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekA 33 
                 +A+ ++G    yl+G gv+++     +w+ k+
  EFC38010.1 221 AAQIQVG--IKYLTGVGVEQNLGASNYWLSKS 250
                 6888899..556*****************995 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.023        70       1      13 [.      17      29 ..      17      41 .. 0.81
   2 ?    0.3   0.1      0.47   1.4e+03       1      13 [.      54      66 ..      54      77 .. 0.86
   3 ?    4.9   0.1     0.016        49       2      20 ..      81     103 ..      80     109 .. 0.75
   4 ?    3.3   0.1     0.051   1.5e+02       1      28 [.     185     216 ..     185     218 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.023
                HHHHHHHHHHHHH CS
       TPR_6  1 dAlyklalsyrkl 13
                dA+y+l+l++ ++
  EFC38010.1 17 DAQYNLGLCFDEG 29
                8*********987 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.47
                HHHHHHHHHHHHH CS
       TPR_6  1 dAlyklalsyrkl 13
                dA+y+ +l+++++
  EFC38010.1 54 DAQYNVGLLFEEG 66
                89********996 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.016
                 HHHHHHHHHHHH....HHHHHHH CS
       TPR_6   2 Alyklalsyrkl....gdtdkAl 20 
                 A+++++++y ++    + ++kAl
  EFC38010.1  81 AQFNIGWLYDEGkgvqKSYEKAL 103
                 99*********855555555555 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.051
                 HHHHHHHHHHHHH....HHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtdkAlealerlik 28 
                 dA y+l+  y+ +    +d+ kA e++ +  k
  EFC38010.1 185 DAIYNLGIFYEFGihvkQDYKKAFELYLKAAK 216
                 799999999999889988*******9977766 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.0    0.0076        23      18      32 ..      97     111 ..      94     135 .. 0.90
   2 ?    4.9   0.2    0.0093        28      17      31 ..     201     215 ..     200     217 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0076
         MIT  18 gnyeeAlelYkeale 32 
                 + ye+Ale+Y +a e
  EFC38010.1  97 KSYEKALEWYMKASE 111
                 78**********987 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0093
         MIT  17 agnyeeAlelYkeal 31 
                 +++y++A+elY +a 
  EFC38010.1 201 KQDYKKAFELYLKAA 215
                 699********9986 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0     0.021        62       1      11 [.      16      26 ..      16      28 .. 0.90
   2 ?   -2.4   0.0       1.7   5.1e+03       3      12 ..      81      90 ..      79      91 .. 0.82
   3 ?    6.4   0.1    0.0029       8.5      14      27 ..      96     109 ..      94     112 .. 0.89
   4 ?   -1.5   0.0      0.86   2.6e+03       2      11 ..     185     194 ..     184     195 .. 0.82
   5 ?    3.4   0.7     0.026        77      15      31 ..     202     218 ..     199     219 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.021
                HHHHHHHHHHH CS
       TPR_1  1 akalynlGnay 11
                a+a ynlG+++
  EFC38010.1 16 ADAQYNLGLCF 26
                89********8 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.7
                HHHHHHHHHH CS
       TPR_1  3 alynlGnayf 12
                a +n+G +y 
  EFC38010.1 81 AQFNIGWLYD 90
                779****995 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0029
                 TT-HHHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyekA 27 
                 ++ y++Ale y kA
  EFC38010.1  96 QKSYEKALEWYMKA 109
                 788*********99 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 0.86
                 HHHHHHHHHH CS
       TPR_1   2 kalynlGnay 11 
                 +a ynlG  y
  EFC38010.1 185 DAIYNLGIFY 194
                 788****987 PP

  == domain 5  score: 3.4 bits;  conditional E-value: 0.026
                 T-HHHHHHHHHHHHHHS CS
       TPR_1  15 gkydeAleyyekALeln 31 
                 ++y++A e y kA + +
  EFC38010.1 202 QDYKKAFELYLKAAKRD 218
                 79999999999998765 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       2.7     8e+03       1      11 [.      16      26 ..      16      28 .. 0.80
   2 ?    6.7   0.8    0.0032       9.7       2      29 ..      80     111 ..      79     112 .. 0.75
   3 ?    4.0   0.5     0.024        73      14      31 ..     201     218 ..     200     219 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.7
                CCHHHHHHHHH CS
       TPR_8  1 aeayynlgsiy 11
                a+a ynlg++ 
  EFC38010.1 16 ADAQYNLGLCF 26
                6899****875 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0032
                 CHHHHHHHHHHH....TT-HHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylk....lgdyeeAkeyyekale 29 
                 +a +n+g++y++    ++ ye+A e+y+ka e
  EFC38010.1  80 HAQFNIGWLYDEgkgvQKSYEKALEWYMKASE 111
                 6677777777654555679**********976 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.024
                 TT-HHHHHHHHHHHHHHH CS
       TPR_8  14 lgdyeeAkeyyekaleld 31 
                 ++dy++A e y ka + d
  EFC38010.1 201 KQDYKKAFELYLKAAKRD 218
                 579***********9876 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.99     3e+03       1      10 [.      16      25 ..      16      28 .. 0.85
   2 ?   -2.6   0.0       2.8   8.3e+03       2      11 ..      80      89 ..      79      91 .. 0.82
   3 ?    3.7   0.1     0.028        84      14      27 ..      96     109 ..      95     112 .. 0.82
   4 ?    5.6   0.6    0.0066        20      15      31 ..     202     218 ..     199     219 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.99
       TPR_2  1 aealynlGla 10
                a+a ynlGl+
  EFC38010.1 16 ADAQYNLGLC 25
                7899****98 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.8
       TPR_2  2 ealynlGlay 11
                 a +n+G++y
  EFC38010.1 80 HAQFNIGWLY 89
                6899****99 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.028
       TPR_2  14 lgdyeeAleafekA 27 
                 ++ ye+Ale++ kA
  EFC38010.1  96 QKSYEKALEWYMKA 109
                 56799999999998 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.0066
       TPR_2  15 gdyeeAleafekAleld 31 
                 +dy++A e++ kA + d
  EFC38010.1 202 QDYKKAFELYLKAAKRD 218
                 89***********9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       467  (0.0260472); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3353.33
//
Query:       EFC38011.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.6e-05   23.3   2.2    3.6e-05   23.3   2.2    1.5  2  FAM76            FAM76 protein
    0.00032   20.2   0.9    0.00032   20.2   0.9    2.1  3  DUF2353          Uncharacterized coiled-coil protein (DUF2353
     0.0054   16.4   2.6     0.0054   16.4   2.6    2.3  2  DUF4795          Domain of unknown function (DUF4795)
      0.009   15.4   4.7      0.012   15.0   3.2    1.8  2  YPEB             YpeB sporulation
  ------ inclusion threshold ------
      0.015   15.1   4.8      0.055   13.3   4.8    1.9  1  SKA2             Spindle and kinetochore-associated protein 2
      0.022   14.5   9.2      0.075   12.8   9.2    1.9  1  DivIC            Septum formation initiator
       0.03   14.5   3.8       0.19   11.9   2.5    2.5  2  Interferon       Interferon alpha/beta domain
      0.033   13.5   3.1      0.062   12.6   3.1    1.4  1  HemX             HemX, putative uroporphyrinogen-III C-methyl
      0.037   14.7   1.7      0.069   13.8   1.7    1.4  1  KfrA_N           Plasmid replication region DNA-binding N-ter
      0.051   13.6   0.8      0.051   13.6   0.8    2.1  2  DUF1664          Protein of unknown function (DUF1664)
      0.079   13.4   1.7       0.15   12.5   0.9    1.9  2  DUF4140          N-terminal domain of unknown function (DUF41
        0.3   11.6  19.6        5.4    7.6  15.5    2.4  2  APG6_N           Apg6 coiled-coil region
       0.34   10.5   3.1       0.71    9.5   3.1    1.5  1  DUF3251          Protein of unknown function (DUF3251)
       0.65   10.4  11.5       0.18   12.2   6.8    2.3  2  CENP-H           Centromere protein H (CENP-H)
       0.79    9.5   6.2        1.6    8.5   6.2    1.5  1  USP8_interact    USP8 interacting
        1.2    9.5   6.4         10    6.6   0.1    2.5  2  Spore_II_R       Stage II sporulation protein R (spore_II_R)
        1.4    9.6  12.6        0.1   13.2   5.9    2.4  2  DUF4404          Domain of unknown function (DUF4404)
        2.1    8.6  10.9        1.9    8.7   8.2    2.4  2  MRPL52           Mitoribosomal protein mL52
        2.3    8.6  17.5       0.11   12.9  10.9    2.1  2  YlqD             YlqD protein
        2.5    8.8   5.1        3.3    8.4   3.0    2.2  2  DUF883           Bacterial protein of unknown function (DUF88
          3    6.6   6.7       0.16   10.8   0.4    1.7  1  LMBR1            LMBR1-like membrane protein
        4.2    8.2  11.1        1.6    9.5   5.4    2.7  3  Occludin_ELL     Occludin homology domain
        4.5    6.4   8.0       0.23   10.7   2.1    1.7  2  TMPIT            TMPIT-like protein
        4.9    7.3  13.7       0.26   11.4   6.4    2.6  2  bZIP_1           bZIP transcription factor
        7.3    6.2  16.5      0.056   13.2   6.1    2.2  2  Cwf_Cwc_15       Cwf15/Cwc15 cell cycle control protein


Domain annotation for each model (and alignments):
>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       3.4   2.4e+03     241     241 ..     113     113 ..      36     143 .. 0.53
   2 !   23.3   2.2     5e-08   3.6e-05     104     276 ..     150     334 ..     148     340 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 3.4
       FAM76 241 e 241
                 +
  EFC38011.1 113 A 113
                 1 PP

  == domain 2  score: 23.3 bits;  conditional E-value: 5e-08
       FAM76 104 qkcAfdrkdedrkkvdGklLCwlCtlsykralakakeeeeekrskskkkkskskkskkskekskekkaskkkskkh...kkrss............... 184
                 +kc f +kd+      Gk   +lC    k + + ++ +   ++s+ + k ++ k+s++s+  ++++ + +++ ++h   +                   
  EFC38011.1 150 EKCRFFKKDDR----SGKFRILLCFAHKKDVENPERLDWFISESAFEVKDQTGKRSNESEADNDSAPKRSREIQEHeplQ---Liptmenmlmlqpiip 241
                 57888877755....69999999999999998888888766666666666666666555555433333333333331331...2333444444444443 PP

       FAM76 185 .rlevskleeeklaeekesnetskk......sldsnssdhlva.vtqLkeeiaslkkqleqkdqellekdkkitelkaellekekelreklkelekeak 275
                  ++++ + +  +   ++++     +      s  +  +++l + vtqLk+e+++lk++le+ +qe  e + +i +l+ + +e++++  +++k+ e +++
  EFC38011.1 242 iHQSIIESS--EELATTPR-----QlfssplSPPPPLTENLTEiVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQIKNPETTHD 333
                 322222222..22222222.....1222345677788888876279**********************************************9999887 PP

       FAM76 276 e 276
                 +
  EFC38011.1 334 H 334
                 6 PP

>> DUF2353  Uncharacterized coiled-coil protein (DUF2353)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.7       3.2   2.3e+03     135     170 ..      33      68 ..      29      71 .. 0.55
   2 ?   -3.9   0.1       9.7   6.9e+03     119     137 ..     214     232 ..     194     236 .. 0.49
   3 !   20.2   0.9   4.4e-07   0.00032       9      51 ..     284     326 ..     242     340 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 3.2
     DUF2353 135 lEklkekiqqlerdlkavldekeelvterdaykeKa 170
                 lE+l  ki+q + +  +v  e  e++   d+y +K 
  EFC38011.1  33 LEELILKIKQAKDNKSDVDSEGLEIKHKIDEYFQKE 68 
                 455555555555555555555555555555555555 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 9.7
     DUF2353 119 etrhssaeereelvkqlEk 137
                 ++r+++++e  +l+  +E+
  EFC38011.1 214 RSREIQEHEPLQLIPTMEN 232
                 2333445555566666655 PP

  == domain 3  score: 20.2 bits;  conditional E-value: 4.4e-07
     DUF2353   9 eALliLskeLekcrqerdqyklmaeqLqerlsalkkqleeeka 51 
                 + ++ L++eLek++qer + k+ +e+L+ +++++k++++++ +
  EFC38011.1 284 QEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQIK 326
                 2345556666666666666666666666666655555444433 PP

>> DUF4795  Domain of unknown function (DUF4795)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.3       1.2   8.5e+02      45      67 ..      31      53 ..      26      70 .. 0.75
   2 !   16.4   2.6   7.5e-06    0.0054       8      57 ..     271     320 ..     251     330 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.2
     DUF4795 45 ealkkqieelekvkadkeeveee 67
                e l++ i + +++k++k++v+ e
  EFC38011.1 31 EILEELILKIKQAKDNKSDVDSE 53
                56777777888888888877654 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 7.5e-06
     DUF4795   8 llkklqeaieklqeelekleekvkelekrledkekklealkkqieelekv 57 
                 l ++l e +++l++e++ l+++ ++++++ ++++ ++e l+ qiee +++
  EFC38011.1 271 LTENLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNS 320
                 578999***************************************99876 PP

>> YPEB  YpeB sporulation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.8   1.3e+03      26      58 ..     109     141 ..     101     148 .. 0.79
   2 !   15.0   3.2   1.6e-05     0.012     111     168 ..     270     327 ..     265     338 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.8
        YPEB  26 eyqrafhdLvshvenleveLgktlavnsreqns 58 
                  y  af+d+ +++ ++ ++++k   +n ++++s
  EFC38011.1 109 IYAFAFFDIRKKITTMSKLVEKNKTINGNKKKS 141
                 577799999999999999999999988887765 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.6e-05
        YPEB 111 pLteeeyktLeeLyeqakelekeLrkvqekvaegglrwgelekalaseqekadntiid 168
                 pLte+  +  ++L++++++l++eL+k+q++ +e++ ++++l+ ++++ +++a+ +i +
  EFC38011.1 270 PLTENLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQIKN 327
                 7899999999**********************************98877766655544 PP

>> SKA2  Spindle and kinetochore-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   4.8   7.7e-05     0.055      43      93 ..     275     321 ..     270     338 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 7.7e-05
        SKA2  43 LlerlkkvkeelqaLkeqceellaekkelidkirttlvanrellqqLqasa 93 
                 L e ++++k+e+q+Lk+++e++++e++e  ++i++        ++++++sa
  EFC38011.1 275 LTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLR----LQIEEMKNSA 321
                 56667899*******************9998887654....3444444444 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   9.2    0.0001     0.075      19      51 ..     279     311 ..     271     318 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 0.0001
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-X CS
       DivIC  19 ykqlkqeiaalqaelaklkaeneeLeaevkdLk 51 
                 + qlkqe+++l++el+k+++e++e + ++++L+
  EFC38011.1 279 VTQLKQEMQTLKQELEKIQQERQEEKTQIENLR 311
                 679****************************96 PP

>> Interferon  Interferon alpha/beta domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.66   4.7e+02       8      68 ..       5      67 ..       2      76 .. 0.61
   2 ?   11.9   2.5   0.00026      0.19      55     119 ..     250     315 ..     231     323 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.66
                HHHHHHHHHCCTSS--S.GGCCCS-S----HHHHH.S--..-HHHHHHHHHHHHHHHHHHCCS CS
  Interferon  8 vnrenlklLsqmrrssplsClkdrkdfefpqeilsgsql..qkeqaalvlhemlqqifnlFst 68
                 n+e+++lL    +ssp s l+  ++  +++ il+ +q   +k+++ +   e+  +i + F++
  EFC38011.1  5 ENWETFRLLPPQTPSSPSSGLSSITSEILEELILKIKQAkdNKSDVDSEGLEIKHKIDEYFQK 67
                567777777666666777777777666666666666665434455555555555555555555 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00026
                 HHHHHHHHHHHCCS--CCCT--HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH.HHCCCCCHHHHH CS
  Interferon  55 lhemlqqifnlFstnessaawnetlleqllsgLhqqleeLeacleeeaeeees.eleeeesrlalk 119
                  +e+ +   +lFs+  s+    ++ l+++ ++L+q+++ L++ le+ ++e ++ + + e+ rl+++
  EFC38011.1 250 SEELATTPRQLFSSPLSPPPPLTENLTEIVTQLKQEMQTLKQELEKIQQERQEeKTQIENLRLQIE 315
                 5666666678999999999999**********************9988777664667777888775 PP

>> HemX  HemX, putative uroporphyrinogen-III C-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   3.1   8.6e-05     0.062      54     105 ..     272     323 ..     241     331 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 8.6e-05
        HemX  54 veaekeqkqeleerlqqlaeklealekeleqlqkqleelqqqlskvsgaerk 105
                 +e++ e  ++l++++q+l+++le+ ++e ++ + q+e+l+ q+++++++ ++
  EFC38011.1 272 TENLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATT 323
                 556667778999999******************************9998554 PP

>> KfrA_N  Plasmid replication region DNA-binding N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   1.7   9.6e-05     0.069      58     112 ..     266     318 ..     242     321 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 9.6e-05
      KfrA_N  58 elPealaeallaalwqaaleeaeeelaaaraelqaaraaleaeraeaearveele 112
                 + P +l+e l  ++ +++++e ++ l+++ +++q++r++ +++ ++++ ++ee++
  EFC38011.1 266 SPPPPLTENL-TEIVTQLKQEMQT-LKQELEKIQQERQEEKTQIENLRLQIEEMK 318
                 5688899999.9999999888877.999999999999999999999999999886 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1         9   6.5e+03      85     100 ..      36      51 ..      26      66 .. 0.44
   2 ?   13.6   0.8   7.1e-05     0.051      75     121 ..     272     318 ..     239     329 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 9
     DUF1664  85 ikeevtevredlseig 100
                 +  ++++++++ s+++
  EFC38011.1  36 LILKIKQAKDNKSDVD 51 
                 2223333333333333 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 7.1e-05
     DUF1664  75 ldeqkeiskeikeevtevredlseigedvesvkeaveglesklerie 121
                  ++ +ei +++k+e+++++++l++i+++ ++ k+ +e+l  ++e+++
  EFC38011.1 272 TENLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMK 318
                 45556666666666666666666666666666666666666666664 PP

>> DUF4140  N-terminal domain of unknown function (DUF4140)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       9.4   6.7e+03      67      86 ..      33      52 ..      14      63 .. 0.61
   2 ?   12.5   0.9   0.00021      0.15      65      97 ..     274     309 ..     244     317 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 9.4
     DUF4140 67 lkalraeleeledelaaled 86
                l++l  ++++++d ++++++
  EFC38011.1 33 LEELILKIKQAKDNKSDVDS 52
                45555555555555555544 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 0.00021
     DUF4140  65 e..e.lkalraeleeledelaaledelaaaearlaf 97 
                 +  e + +l++e+++l++el+++++e++  +++++ 
  EFC38011.1 274 NltEiVTQLKQEMQTLKQELEKIQQERQEEKTQIEN 309
                 144446666666666666666666666666666653 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.1     0.024        17      63     107 ..      33      77 ..      22      89 .. 0.89
   2 ?    7.6  15.5    0.0075       5.4      50     103 ..     273     326 ..     199     341 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.024
      APG6_N  63 eeelleeLkelekereeleaelaaleeelealeeeeerfwreyne 107
                  eel+ ++k+++++++++++e  +++ + ++  ++e+r + + ne
  EFC38011.1  33 LEELILKIKQAKDNKSDVDSEGLEIKHKIDEYFQKENRNFLDPNE 77 
                 578999*************************99999998887776 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0075
      APG6_N  50 eeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwr 103
                 e+l e + +l++e ++l +eL+++++er+e + ++++l+ + e++++  +  ++
  EFC38011.1 273 ENLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQIK 326
                 56777799**********************************999998777665 PP

>> DUF3251  Protein of unknown function (DUF3251)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   3.1   0.00099      0.71       9      34 ..     274     299 ..     270     312 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00099
                 ---S-------------HHHHHHHHH CS
     DUF3251   9 qlkqsvsklnqelktleqetvkieqq 34 
                 +l++ v++l+qe++tl+qe+ ki+q+
  EFC38011.1 274 NLTEIVTQLKQEMQTLKQELEKIQQE 299
                 68999******************997 PP

>> CENP-H  Centromere protein H (CENP-H)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       2.8     2e+03      19      42 ..      37      60 ..      26      72 .. 0.40
   2 ?   12.2   6.8   0.00025      0.18      10      61 ..     274     325 ..     270     337 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 2.8
      CENP-H 19 sqelrelqeeltevekenlrlkrk 42
                  ++++++++ ++v  e l++k+k
  EFC38011.1 37 ILKIKQAKDNKSDVDSEGLEIKHK 60
                222222333333333333333333 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00025
      CENP-H  10 elssellklsqelrelqeeltevekenlrlkrknrelaaellelakekesek 61 
                 +l + + +l+qe+++l++el+++++e+ + k++ ++l  +++e ++ + ++ 
  EFC38011.1 274 NLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQI 325
                 5677899**********************************77666666554 PP

>> USP8_interact  USP8 interacting
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   6.2    0.0022       1.6       2      49 ..     275     322 ..     274     337 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0022
  USP8_interact   2 Lrelvqkqqqkiaelkkevaeqkqqlseqkrelellkeyiralrstnp 49 
                    L e+v++ +q++++lk+e+++ +q+ +e+k ++e l+  i  ++++ +
     EFC38011.1 275 LTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSAT 322
                    889999****************************99999999886553 PP

>> Spore_II_R  Stage II sporulation protein R (spore_II_R)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.1     0.014        10      28     101 ..      35     109 ..      23     111 .. 0.73
   2 ?    4.1   2.4     0.086        61      28      83 ..     288     343 ..     273     344 .] 0.64

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.014
  Spore_II_R  28 avleeleellkeakske.eaeelikenleeieeiaeevlekegvdykvkvelgkeyfpekeYgdltlpaGeYeal 101
                 +++ +++++ +++++ + e  e+ ++  e ++++ ++ l  ++    ++++l++++f +k ++  + +  +Y+a+
  EFC38011.1  35 ELILKIKQAKDNKSDVDsEGLEIKHKIDEYFQKENRNFLDPNENAGIINLKLSDVTFTRKAFEISITNFAKYKAI 109
                 44444444444444444144555555566789999999999999999****************999999999997 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.086
  Spore_II_R  28 avleeleellkeakskeeaeelikenleeieeiaeevlekegvdykvkvelgkeyf 83 
                 ++ +ele+  +e ++++ + e ++ ++ee+++ a++++++ +++++ + ++++e f
  EFC38011.1 288 TLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQIKNPETTHDHDFNFDEEPF 343
                 34444555554555556666777778888888888888888888777777776655 PP

>> DUF4404  Domain of unknown function (DUF4404)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2         4   2.9e+03      22      46 ..      29      53 ..      22      68 .. 0.70
   2 ?   13.2   5.9   0.00014       0.1       1      47 [.     282     328 ..     282     339 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 4
     DUF4404 22 tralLeslaedieellaeedaaaee 46
                t + Le+l+ +i+++ +++++ ++e
  EFC38011.1 29 TSEILEELILKIKQAKDNKSDVDSE 53
                6677888888888887777777666 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 0.00014
     DUF4404   1 LkelLekLheeLeqnesldeetralLeslaedieellaeedaaaeee 47 
                 Lk+++++L++eLe+ ++  +e++ ++e+l+ +iee+ ++ +++ +++
  EFC38011.1 282 LKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQIKNP 328
                 89********************************9999888877665 PP

>> MRPL52  Mitoribosomal protein mL52
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       5.8   4.1e+03      52      66 ..     119     133 ..     112     145 .. 0.44
   2 ?    8.7   8.2    0.0026       1.9      48      88 ..     273     313 ..     271     317 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 5.8
      MRPL52  52 kkivkllsEideaee 66 
                 kki ++++ +++ ++
  EFC38011.1 119 KKITTMSKLVEKNKT 133
                 333333333333332 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0026
      MRPL52  48 eelakkivkllsEideaeerykkkqeeeeeeeqkiiesklk 88 
                 e+l++++ +l +E+++ ++  +k q+e++ee+ +i++ +l+
  EFC38011.1 273 ENLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQ 313
                 68999*******************************99986 PP

>> YlqD  YlqD protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       7.4   5.3e+03      56      66 ..      53      66 ..      28      79 .. 0.45
   2 ?   12.9  10.9   0.00015      0.11      22      78 ..     272     327 ..     270     334 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 7.4
        YlqD 56 q...qieeiqeqve 66
                +    +++i e ++
  EFC38011.1 53 EgleIKHKIDEYFQ 66
                12223333444444 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 0.00015
        YlqD  22 qqqlqaqieqldkelqqLefqakrlikeikkqsaqqieeiqeqvekekserlekkkq 78 
                  ++l++ ++ql++e+q L+++++++ +e ++ +++qie+++ q+e+ k+  + ++k+
  EFC38011.1 272 TENLTEIVTQLKQEMQTLKQELEKIQQERQE-EKTQIENLRLQIEEMKNSATTQIKN 327
                 67899999*****************998877.666**************99999886 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       4.4   3.1e+03      15      42 ..      41      67 ..      27      77 .. 0.63
   2 ?    8.4   3.0    0.0046       3.3       2      49 ..     281     327 ..     280     335 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 4.4
      DUF883 15 eellkeaadeageeaeelRerleerler 42
                ++   + +++ ++e  e++ +++e++++
  EFC38011.1 41 KQAK-DNKSDVDSEGLEIKHKIDEYFQK 67
                4433.44455666677788888877765 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0046
      DUF883   2 eleaeleslladleellkeaadeageeaeelRerleerlerarerlrd 49 
                 +l++e+++l ++le++ +e + e + ++e+lR ++ee+ ++a  ++++
  EFC38011.1 281 QLKQEMQTLKQELEKIQQERQ-EEKTQIENLRLQIEEMKNSATTQIKN 327
                 799************986665.68999**********99999888765 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.4   0.00023      0.16     183     238 ..     253     322 ..     252     335 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00023
       LMBR1 183 lvelPrslwr..............eiksdldeelkklyfeaaklntekeeaereledllkevkklrksis 238
                 l+ +Pr+l+               ei ++l++e++ l+ e++k+++e++e + ++e+l  +++++++s +
  EFC38011.1 253 LATTPRQLFSsplsppppltenltEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSAT 322
                 78899999999******99999999*************************99999999888888877765 PP

>> Occludin_ELL  Occludin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0       1.9   1.3e+03      38      77 ..      33      74 ..      24      89 .. 0.53
   2 ?   -1.4   0.0       5.4   3.9e+03      21      51 ..     103     134 ..     100     159 .. 0.62
   3 ?    9.5   5.4    0.0022       1.6      26      77 ..     274     325 ..     272     332 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 1.9
  Occludin_ELL 38 fseLerelkelkegsk....eykkieeeilqeykklkkdpeyqe 77
                  ++eL  ++k++k++++    e  +i+++ ++ey ++ +++++++
    EFC38011.1 33 LEELILKIKQAKDNKSdvdsEGLEIKHK-IDEYFQK-ENRNFLD 74
                  5555556666666666333344444445.3333333.3555555 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 5.4
  Occludin_ELL  21 YkeYkelhael.eevskkfseLerelkelkeg 51 
                   +++Yk+++a    +++kk++ +++ +++ k+ 
    EFC38011.1 103 FAKYKAIYAFAfFDIRKKITTMSKLVEKNKTI 134
                   66777777643266677776666665555443 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.0022
  Occludin_ELL  26 elhaeleevskkfseLerelkelkegskeykkieeeilqeykklkkdpeyqe 77 
                   +l + +++++++++ L++el++ +++++e+k+ +e++  + +++k++++ q 
    EFC38011.1 274 NLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQI 325
                   688999******************************9*******99887765 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.4       2.1   1.5e+03      63     111 ..      47      94 ..      26     133 .. 0.49
   2 ?   10.7   2.1   0.00032      0.23      35      83 ..     275     322 ..     248     335 .. 0.66

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.1
       TMPIT  63 eeeeeveelkeelkerkkvlkevesllpkk.nglylklvlGnvnvsllnk 111
                 +++   e l+ + k  +   ke  ++l  + n   ++l l +  v++++k
  EFC38011.1  47 KSDVDSEGLEIKHKIDEYFQKENRNFLDPNeNAGIINLKLSD--VTFTRK 94 
                 333333333333333333333444444333355555554433..344444 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00032
       TMPIT  35 cskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelkerkkvlk 83 
                 +++ +++ k++++ lk++l+k++++ ++ee++++e+l+ +++e+k++  
  EFC38011.1 275 LTEIVTQLKQEMQTLKQELEKIQQE-RQEEKTQIENLRLQIEEMKNSAT 322
                 4444555566666666666666655.34556666666666666555433 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.4       3.6   2.6e+03      46      61 ..     118     133 ..     116     140 .. 0.62
   2 ?   11.4   6.4   0.00036      0.26      28      63 ..     272     307 ..     271     308 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 3.6
                 HHHHHHHHHHHHHHHH CS
      bZIP_1  46 kseleelkkevekLks 61 
                 ++++ +++k vek k+
  EFC38011.1 118 RKKITTMSKLVEKNKT 133
                 5666666666666554 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00036
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  28 ieeLerrvkaLekeNksLkseleelkkevekLkskv 63 
                 +e+L++ v +L++e+++Lk+ele+++ e+++ k+++
  EFC38011.1 272 TENLTEIVTQLKQEMQTLKQELEKIQQERQEEKTQI 307
                 589***************************988876 PP

>> Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.2       0.6   4.3e+02     164     182 ..     199     217 ..     117     234 .. 0.66
   2 ?   13.2   6.1   7.8e-05     0.056     145     188 ..     285     328 ..     280     339 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.6
                 ------------------- CS
  Cwf_Cwc_15 164 kerkerekaeeeekereee 182
                 k+ +e+e++++++ +r++e
  EFC38011.1 199 KRSNESEADNDSAPKRSRE 217
                 1122222222222233333 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 7.8e-05
                 -------------------------------------------- CS
  Cwf_Cwc_15 145 etaeLlrELekikreraeekerkerekaeeeekereeeiatgNp 188
                 e + L +ELeki++er+eek++ e+ + + ee + ++    +Np
  EFC38011.1 285 EMQTLKQELEKIQQERQEEKTQIENLRLQIEEMKNSATTQIKNP 328
                 7889***********************99999999999888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2756  (0.153717); expected 358.6 (0.02)
Passed bias filter:                     1003  (0.0559429); expected 358.6 (0.02)
Passed Vit filter:                       232  (0.0129399); expected 17.9 (0.001)
Passed Fwd filter:                        33  (0.00184059); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              25  [number of targets reported over threshold]
# CPU time: 0.80u 0.42s 00:00:01.22 Elapsed: 00:00:00.57
# Mc/sec: 1825.19
//
Query:       EFC38012.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.017   15.1   5.1       0.08   12.9   1.3    2.4  2  NCD3G            Nine Cysteines Domain of family 3 GPCR
       0.66    9.8  13.2        6.3    6.7  12.7    2.4  1  Ephrin_rec_like  Putative ephrin-receptor like
          1    9.8  10.2         39    4.7  10.2    2.5  1  TNFR_c6          TNFR/NGFR cysteine-rich region


Domain annotation for each model (and alignments):
>> NCD3G  Nine Cysteines Domain of family 3 GPCR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.1     0.015        88      31      51 ..      23      47 ..      21      48 .. 0.63
   2 ?   12.9   1.3   1.3e-05      0.08      30      48 ..      56      76 ..      53      79 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.015
       NCD3G 31 Cpegeis....tdseeCtkCpedew 51
                C  g +     +d ++C +C+ +++
  EFC38012.1 23 CDPGYYYaptpNDLDRCLPCDYGYY 47
                6666644354448888888887665 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 1.3e-05
       NCD3G 30 pCpegeist..dseeCtkCpe 48
                +Cp g+ist   s++C+kCp 
  EFC38012.1 56 KCPPGTISTrkASTSCMKCPA 76
                8*******7668999****96 PP

>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7  12.7    0.0011       6.3       6      48 .]      34      74 ..      26      85 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0011
  Ephrin_rec_like  6 tgletCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48
                     + l +C pC  g+Y +  g+ s ++CP+gt  +  ++ts  +C
       EFC38012.1 34 NDLDRCLPCDYGYYCP--GNDSANKCPPGTISTRKASTSCMKC 74
                     67899*********98..7888899************998888 PP

>> TNFR_c6  TNFR/NGFR cysteine-rich region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7  10.2    0.0066        39       1      30 [.      23      66 ..      23      89 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0066
                --TTEE.CCCTCTC.SEEEE............E-BGCTEEECC- CS
     TNFR_c6  1 CpegtY.tdnensk.eClpC............trCppgqvvlrp 30
                C +g+Y  + +n+  +ClpC             +Cppg+  +r 
  EFC38012.1 23 CDPGYYyAPTPNDLdRCLPCdygyycpgndsaNKCPPGTISTRK 66
                ****875555577777****999888888877778888877666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       446  (0.0248759); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.55
# Mc/sec: 1848.84
//
Query:       EFC38013.1  [L=3160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-22   75.6 119.6        0.7    9.9   0.7   40.7 48  IQ        IQ calmodulin-binding motif


Domain annotation for each model (and alignments):
>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0      0.51   9.1e+03       6      17 ..     988     999 ..     988     999 .. 0.86
   2 ?   -2.7   0.2      0.41   7.4e+03       4      15 ..    1009    1020 ..    1008    1021 .. 0.85
   3 !    3.1   0.3     0.006   1.1e+02       4      18 ..    1032    1046 ..    1030    1049 .. 0.84
   4 !    3.4   0.1    0.0047        83       2      13 ..    1053    1064 ..    1052    1066 .. 0.89
   5 !    4.5   0.1    0.0021        38       3      19 ..    1100    1116 ..    1098    1117 .. 0.86
   6 ?   -0.2   0.0     0.067   1.2e+03       2      13 ..    1191    1202 ..    1190    1209 .. 0.83
   7 !    6.7   0.0   0.00041       7.3       4      21 .]    1216    1233 ..    1213    1233 .. 0.90
   8 ?   -1.2   0.0      0.14   2.6e+03       3      17 ..    1238    1252 ..    1237    1254 .. 0.79
   9 ?   -1.8   0.0      0.21   3.8e+03       4      15 ..    1285    1296 ..    1284    1299 .. 0.88
  10 ?    1.3   0.0     0.022   3.9e+02       9      21 .]    1313    1325 ..    1313    1325 .. 0.90
  11 ?    0.1   0.2     0.055   9.9e+02       4      17 ..    1331    1344 ..    1329    1345 .. 0.85
  12 ?   -2.7   0.0      0.44   7.9e+03       3      11 ..    1353    1361 ..    1352    1361 .. 0.85
  13 ?    1.0   0.1     0.027   4.8e+02       3      15 ..    1491    1503 ..    1489    1506 .. 0.82
  14 !    9.9   0.7   3.9e-05       0.7       2      21 .]    1559    1578 ..    1558    1578 .. 0.87
  15 ?   -3.5   0.0      0.75   1.3e+04       9      21 .]    1612    1624 ..    1609    1624 .. 0.81
  16 !    6.3   0.0   0.00054       9.7       7      19 ..    1656    1668 ..    1655    1669 .. 0.91
  17 ?    0.5   0.0     0.038   6.9e+02       3      15 ..    1698    1710 ..    1696    1714 .. 0.85
  18 !    9.3   0.0     6e-05       1.1       4      18 ..    1745    1759 ..    1742    1761 .. 0.91
  19 ?    1.6   0.0     0.018   3.2e+02       4      16 ..    1768    1780 ..    1765    1785 .. 0.83
  20 ?    0.3   0.0     0.048   8.5e+02       4      15 ..    1814    1825 ..    1812    1830 .. 0.82
  21 ?   -1.7   0.0       0.2   3.6e+03       7      14 ..    1840    1847 ..    1838    1849 .. 0.90
  22 ?   -3.8   0.0      0.94   1.7e+04       4      18 ..    1883    1897 ..    1882    1899 .. 0.80
  23 ?    0.9   0.0      0.03   5.4e+02       4      20 ..    1906    1922 ..    1905    1923 .. 0.87
  24 !    7.8   0.0   0.00018       3.2       8      20 ..    1933    1945 ..    1933    1946 .. 0.96
  25 !    7.1   0.0    0.0003       5.4       1      13 [.    1949    1961 ..    1949    1962 .. 0.92
  26 !    3.9   0.0    0.0033        59       4      15 ..    1975    1986 ..    1973    1989 .. 0.84
  27 ?   -2.2   0.1       0.3   5.4e+03       6      15 ..    2065    2074 ..    2065    2074 .. 0.89
  28 ?    0.4   0.0     0.044   7.9e+02       6      16 ..    2157    2167 ..    2153    2168 .. 0.87
  29 !    5.9   0.1   0.00073        13       6      19 ..    2180    2193 ..    2175    2195 .. 0.84
  30 !    3.0   0.3    0.0064   1.2e+02       4      13 ..    2245    2254 ..    2242    2255 .. 0.89
  31 ?    0.3   0.0     0.044     8e+02       6      20 ..    2385    2399 ..    2385    2400 .. 0.89
  32 ?    1.8   0.2     0.015   2.6e+02       2      13 ..    2404    2415 ..    2403    2416 .. 0.88
  33 !    3.4   0.0    0.0046        82       3      13 ..    2428    2438 ..    2426    2442 .. 0.89
  34 ?   -0.1   0.1     0.064   1.2e+03       4      13 ..    2448    2457 ..    2446    2458 .. 0.88
  35 ?    0.7   0.0     0.033     6e+02       3      13 ..    2493    2503 ..    2491    2509 .. 0.81
  36 !    2.7   0.1     0.008   1.4e+02       2      19 ..    2517    2534 ..    2516    2536 .. 0.84
  37 ?    1.4   0.1     0.021   3.7e+02       2      20 ..    2655    2673 ..    2654    2674 .. 0.79
  38 !    6.6   0.0   0.00042       7.5       3      20 ..    2681    2698 ..    2680    2699 .. 0.92
  39 !    3.6   0.0     0.004        72       6      17 ..    2707    2718 ..    2707    2720 .. 0.90
  40 !    3.3   0.0    0.0049        87       5      20 ..    2729    2744 ..    2726    2745 .. 0.85
  41 !    8.1   0.1   0.00014       2.5       3      20 ..    2819    2836 ..    2817    2837 .. 0.89
  42 ?   -2.8   0.0      0.47   8.5e+03       6      14 ..    2868    2876 ..    2866    2880 .. 0.83
  43 !    6.5   0.0   0.00046       8.3       5      20 ..    2890    2905 ..    2888    2906 .. 0.93
  44 ?    1.3   0.1     0.021   3.8e+02       7      21 .]    2919    2933 ..    2918    2933 .. 0.89
  45 ?   -2.3   0.1      0.31   5.6e+03       7      14 ..    2965    2972 ..    2962    2974 .. 0.84
  46 ?   -3.2   0.2      0.63   1.1e+04       3      12 ..    3030    3039 ..    3029    3040 .. 0.87
  47 ?   -3.4   0.0       0.7   1.3e+04       6      19 ..    3079    3092 ..    3079    3092 .. 0.89
  48 !    3.8   0.1    0.0033        60       2      18 ..    3102    3118 ..    3101    3119 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.51
                 HHHHHHHHHHHH CS
          IQ   6 kIQaawRGylaR 17 
                 +IQ+  R  l R
  EFC38013.1 988 CIQSLSRSKLER 999
                 6******99876 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.41
                  HHHHHHHHHHHH CS
          IQ    4 aikIQaawRGyl 15  
                  ++++Q+  R  l
  EFC38013.1 1009 IVILQSISRSRL 1020
                  79*****99866 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.006
                  HHHHHHHHHHHHHHH CS
          IQ    4 aikIQaawRGylaRk 18  
                  +i++Q+ +R++   k
  EFC38013.1 1032 IITLQSLVRRHHKQK 1046
                  8*********98666 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.0047
                  HHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRG 13  
                  +a+ ++Q+++RG
  EFC38013.1 1053 EAIQIMQSFCRG 1064
                  6999*******9 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.0021
                  HHHHHHHHHHHHHHHHH CS
          IQ    3 aaikIQaawRGylaRkr 19  
                   +i++Q+ +RG  a+k+
  EFC38013.1 1100 RIILLQSLVRGRAAMKE 1116
                  69*********999886 PP

  == domain 6  score: -0.2 bits;  conditional E-value: 0.067
                  HHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRG 13  
                  ++a++IQ  +R+
  EFC38013.1 1191 DSAVVIQGLFRA 1202
                  69*****99997 PP

  == domain 7  score: 6.7 bits;  conditional E-value: 0.00041
                  HHHHHHHHHHHHHHHHHH CS
          IQ    4 aikIQaawRGylaRkryk 21  
                  + +IQ+ + G  +Rk+y+
  EFC38013.1 1216 IKVIQSTILGCNQRKKYQ 1233
                  789**************6 PP

  == domain 8  score: -1.2 bits;  conditional E-value: 0.14
                  HHHHHHHHHHHHHHH CS
          IQ    3 aaikIQaawRGylaR 17  
                  ++ ++Qa +R+ l +
  EFC38013.1 1238 SIPLLQALIRRILLK 1252
                  56789*****98865 PP

  == domain 9  score: -1.8 bits;  conditional E-value: 0.21
                  HHHHHHHHHHHH CS
          IQ    4 aikIQaawRGyl 15  
                  +++IQ   R++ 
  EFC38013.1 1285 ITTIQTLSRRFI 1296
                  79******9985 PP

  == domain 10  score: 1.3 bits;  conditional E-value: 0.022
                  HHHHHHHHHHHHH CS
          IQ    9 aawRGylaRkryk 21  
                  +a+RG+ aR  +k
  EFC38013.1 1313 SAIRGFNARTTFK 1325
                  78*******9887 PP

  == domain 11  score: 0.1 bits;  conditional E-value: 0.055
                  HHHHHHHHHHHHHH CS
          IQ    4 aikIQaawRGylaR 17  
                  +++ Q+ +R+ l  
  EFC38013.1 1331 ITLVQSLIRAKLIQ 1344
                  899*******9976 PP

  == domain 12  score: -2.7 bits;  conditional E-value: 0.44
                  HHHHHHHHH CS
          IQ    3 aaikIQaaw 11  
                  a ++IQ+++
  EFC38013.1 1353 ASTLIQSVC 1361
                  789****97 PP

  == domain 13  score: 1.0 bits;  conditional E-value: 0.027
                  HHHHHHHHHHHHH CS
          IQ    3 aaikIQaawRGyl 15  
                  aa +IQ++ RG l
  EFC38013.1 1491 AAHLIQSRARGTL 1503
                  6668*******87 PP

  == domain 14  score: 9.9 bits;  conditional E-value: 3.9e-05
                  HHHHHHHHHHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRGylaRkryk 21  
                  + + +IQ++ RG ++R+ ++
  EFC38013.1 1559 RKVSTIQSWLRGVQTRRGFQ 1578
                  56789************885 PP

  == domain 15  score: -3.5 bits;  conditional E-value: 0.75
                  HHHHHHHHHHHHH CS
          IQ    9 aawRGylaRkryk 21  
                  +  +G+++R ++k
  EFC38013.1 1612 SLMKGHVQRLEHK 1624
                  6789*****9876 PP

  == domain 16  score: 6.3 bits;  conditional E-value: 0.00054
                  HHHHHHHHHHHHH CS
          IQ    7 IQaawRGylaRkr 19  
                  IQ a R yl+Rk 
  EFC38013.1 1656 IQTAARSYLTRKD 1668
                  9**********96 PP

  == domain 17  score: 0.5 bits;  conditional E-value: 0.038
                  HHHHHHHHHHHHH CS
          IQ    3 aaikIQaawRGyl 15  
                   +i++Qa+++ +l
  EFC38013.1 1698 LIITLQARVKTFL 1710
                  59*******9998 PP

  == domain 18  score: 9.3 bits;  conditional E-value: 6e-05
                  HHHHHHHHHHHHHHH CS
          IQ    4 aikIQaawRGylaRk 18  
                  ++++Qa +RG+ aRk
  EFC38013.1 1745 ILTLQASVRGFIARK 1759
                  889***********9 PP

  == domain 19  score: 1.6 bits;  conditional E-value: 0.018
                  HHHHHHHHHHHHH CS
          IQ    4 aikIQaawRGyla 16  
                  +++IQ+  R+ l+
  EFC38013.1 1768 VTVIQSLSRRQLT 1780
                  79********997 PP

  == domain 20  score: 0.3 bits;  conditional E-value: 0.048
                  HHHHHHHHHHHH CS
          IQ    4 aikIQaawRGyl 15  
                  + ++Qa++R  l
  EFC38013.1 1814 IKTLQARIRSKL 1825
                  679******988 PP

  == domain 21  score: -1.7 bits;  conditional E-value: 0.2
                  HHHHHHHH CS
          IQ    7 IQaawRGy 14  
                   Qa++RG+
  EFC38013.1 1840 VQAVVRGH 1847
                  6******9 PP

  == domain 22  score: -3.8 bits;  conditional E-value: 0.94
                  HHHHHHHHHHHHHHH CS
          IQ    4 aikIQaawRGylaRk 18  
                  + ++Q+ +  +  R 
  EFC38013.1 1883 IKILQSLILSHTLRA 1897
                  5699***99998885 PP

  == domain 23  score: 0.9 bits;  conditional E-value: 0.03
                  HHHHHHHHHHHHHHHHH CS
          IQ    4 aikIQaawRGylaRkry 20  
                  +i +Q+  RG   Rk++
  EFC38013.1 1906 IINLQSSMRGRDERKNL 1922
                  899*******9888876 PP

  == domain 24  score: 7.8 bits;  conditional E-value: 0.00018
                  HHHHHHHHHHHHH CS
          IQ    8 QaawRGylaRkry 20  
                  Qa +RGyl Rk++
  EFC38013.1 1933 QALIRGYLERKNF 1945
                  9**********98 PP

  == domain 25  score: 7.1 bits;  conditional E-value: 0.0003
                  HHHHHHHHHHHHH CS
          IQ    1 rkaaikIQaawRG 13  
                  +++++ IQa++RG
  EFC38013.1 1949 HDSITNIQAFFRG 1961
                  689*********9 PP

  == domain 26  score: 3.9 bits;  conditional E-value: 0.0033
                  HHHHHHHHHHHH CS
          IQ    4 aikIQaawRGyl 15  
                  +++IQ+a+RG  
  EFC38013.1 1975 VLVIQSAIRGKH 1986
                  689*******76 PP

  == domain 27  score: -2.2 bits;  conditional E-value: 0.3
                  HHHHHHHHHH CS
          IQ    6 kIQaawRGyl 15  
                  ++Q+ +R++l
  EFC38013.1 2065 IMQSLVRRFL 2074
                  68******98 PP

  == domain 28  score: 0.4 bits;  conditional E-value: 0.044
                  HHHHHHHHHHH CS
          IQ    6 kIQaawRGyla 16  
                  +IQ+a R  l+
  EFC38013.1 2157 IIQSAARSNLV 2167
                  8******9986 PP

  == domain 29  score: 5.9 bits;  conditional E-value: 0.00073
                  HHHHHHHHHHHHHH CS
          IQ    6 kIQaawRGylaRkr 19  
                   +Qa +RG+ +R +
  EFC38013.1 2180 SLQALIRGHIVRNN 2193
                  69**********75 PP

  == domain 30  score: 3.0 bits;  conditional E-value: 0.0064
                  HHHHHHHHHH CS
          IQ    4 aikIQaawRG 13  
                  +i+IQ+a+R 
  EFC38013.1 2245 IITIQSAFRS 2254
                  8********5 PP

  == domain 31  score: 0.3 bits;  conditional E-value: 0.044
                  HHHHHHHHHHHHHHH CS
          IQ    6 kIQaawRGylaRkry 20  
                  +IQ+ +R   +R ++
  EFC38013.1 2385 IIQSLIRNRFTRAEF 2399
                  7*******9999887 PP

  == domain 32  score: 1.8 bits;  conditional E-value: 0.015
                  HHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRG 13  
                   a++ IQa++R 
  EFC38013.1 2404 NAVLAIQARCRS 2415
                  69999******5 PP

  == domain 33  score: 3.4 bits;  conditional E-value: 0.0046
                  HHHHHHHHHHH CS
          IQ    3 aaikIQaawRG 13  
                   +++IQa+ RG
  EFC38013.1 2428 NITIIQAFLRG 2438
                  59********9 PP

  == domain 34  score: -0.1 bits;  conditional E-value: 0.064
                  HHHHHHHHHH CS
          IQ    4 aikIQaawRG 13  
                  +i++Qa +R+
  EFC38013.1 2448 IIVLQALVRR 2457
                  8********7 PP

  == domain 35  score: 0.7 bits;  conditional E-value: 0.033
                  HHHHHHHHHHH CS
          IQ    3 aaikIQaawRG 13  
                   +i++Qa +R 
  EFC38013.1 2493 KIIVLQALIRN 2503
                  69********6 PP

  == domain 36  score: 2.7 bits;  conditional E-value: 0.008
                  HHHHHHHHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRGylaRkr 19  
                   a   IQa +R+ + R +
  EFC38013.1 2517 NATQMIQALVRANKERSN 2534
                  67789********99976 PP

  == domain 37  score: 1.4 bits;  conditional E-value: 0.021
                  HHHHHHHHHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRGylaRkry 20  
                  k ++ +Qa++R     ++y
  EFC38013.1 2655 KHILNLQAVCRSRSIQQEY 2673
                  56899******98777777 PP

  == domain 38  score: 6.6 bits;  conditional E-value: 0.00042
                  HHHHHHHHHHHHHHHHHH CS
          IQ    3 aaikIQaawRGylaRkry 20  
                  ++++IQ a RG   Rk++
  EFC38013.1 2681 SITIIQNAARGNTDRKNH 2698
                  79*************986 PP

  == domain 39  score: 3.6 bits;  conditional E-value: 0.004
                  HHHHHHHHHHHH CS
          IQ    6 kIQaawRGylaR 17  
                  ++Qaa RGy aR
  EFC38013.1 2707 TLQAASRGYSAR 2718
                  69*********9 PP

  == domain 40  score: 3.3 bits;  conditional E-value: 0.0049
                  HHHHHHHHHHHHHHHH CS
          IQ    5 ikIQaawRGylaRkry 20  
                  + IQ+ +R  la k +
  EFC38013.1 2729 THIQSLCRKQLALKTF 2744
                  67*********98766 PP

  == domain 41  score: 8.1 bits;  conditional E-value: 0.00014
                  HHHHHHHHHHHHHHHHHH CS
          IQ    3 aaikIQaawRGylaRkry 20  
                   + +IQa ++  laR+ +
  EFC38013.1 2819 NIAIIQALFKSQLARRSF 2836
                  6889************87 PP

  == domain 42  score: -2.8 bits;  conditional E-value: 0.47
                  HHHHHHHHH CS
          IQ    6 kIQaawRGy 14  
                  ++Q+++R +
  EFC38013.1 2868 IFQSRVRTF 2876
                  79*****87 PP

  == domain 43  score: 6.5 bits;  conditional E-value: 0.00046
                  HHHHHHHHHHHHHHHH CS
          IQ    5 ikIQaawRGylaRkry 20  
                  i+IQ ++R  l+++ +
  EFC38013.1 2890 IVIQTFFRSNLVKRSF 2905
                  89***********988 PP

  == domain 44  score: 1.3 bits;  conditional E-value: 0.021
                  HHHHHHHHHHHHHHH CS
          IQ    7 IQaawRGylaRkryk 21  
                  I a +R+ ++R+++k
  EFC38013.1 2919 IIALYRANQTRQEFK 2933
                  6689*********98 PP

  == domain 45  score: -2.3 bits;  conditional E-value: 0.31
                  HHHHHHHH CS
          IQ    7 IQaawRGy 14  
                  +Q+ +RG 
  EFC38013.1 2965 LQSIIRGR 2972
                  8*****95 PP

  == domain 46  score: -3.2 bits;  conditional E-value: 0.63
                  HHHHHHHHHH CS
          IQ    3 aaikIQaawR 12  
                  ++ ++Qa++R
  EFC38013.1 3030 SISLLQARVR 3039
                  7889****99 PP

  == domain 47  score: -3.4 bits;  conditional E-value: 0.7
                  HHHHHHHHHHHHHH CS
          IQ    6 kIQaawRGylaRkr 19  
                  +IQ   RG  +Rk+
  EFC38013.1 3079 TIQGLLRGSFTRKQ 3092
                  699999******96 PP

  == domain 48  score: 3.8 bits;  conditional E-value: 0.0033
                  HHHHHHHHHHHHHHHHH CS
          IQ    2 kaaikIQaawRGylaRk 18  
                  ++ ++IQa  R++l+ k
  EFC38013.1 3102 SSTTTIQAIGRRFLTAK 3118
                  589**********9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (3160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1482  (0.0826594); expected 358.6 (0.02)
Passed bias filter:                      304  (0.0169558); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.38u 0.32s 00:00:01.70 Elapsed: 00:00:00.55
# Mc/sec: 17182.03
//
Query:       EFC38014.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.2e-12   44.9   0.1    1.3e-11   44.4   0.1    1.1  1  Thioredoxin    Thioredoxin
    0.00077   18.9   0.1     0.0011   18.4   0.1    1.3  1  OST3_OST6      OST3 / OST6 family, transporter family
     0.0014   18.6   0.0     0.0023   17.8   0.0    1.4  1  HyaE           Hydrogenase-1 expression protein HyaE
  ------ inclusion threshold ------
      0.038   12.9   0.0      0.043   12.8   0.0    1.1  1  Phosducin      Phosducin
       0.14   12.6   0.0        0.2   12.1   0.0    1.2  1  Thioredoxin_2  Thioredoxin-like domain


Domain annotation for each model (and alignments):
>> Thioredoxin  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.4   0.1   3.6e-15   1.3e-11      37     102 ..       4      67 ..       2      68 .. 0.94

  Alignments for each domain:
  == domain 1  score: 44.4 bits;  conditional E-value: 3.6e-15
                  HHHHHHHHHHCTTTSEEEEEETTTSHHHHHHTT-SSSSEEEEEETTEEEEEEESS-HHHHHHHHHH CS
  Thioredoxin  37 aPeleklaeelkdkvklakvdvdenedlakkyevegiPtlklfkngkevkkyegarekeklaaflk 102
                  +P++e+l++++  +  ++ vdvd+++d+a++y+v+++Pt+++fk+g +  +++ga   +k+++++k
   EFC38014.1   4 KPKFEQLSTKYP-NTNFVSVDVDQSQDIASQYSVSSLPTFLFFKAGSKLGQIVGADM-DKVEDMIK 67 
                  79**********.******************************************88.88888776 PP

>> OST3_OST6  OST3 / OST6 family, transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.1   3.1e-07    0.0011      57     107 ..       8      50 ..       1      78 [. 0.73

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.1e-07
   OST3_OST6  57 elvakswrkdekskskklfFakvdfdegkdvFqklglnsaPhlllfppkkg 107
                 e+++  + ++         F++vd+d+++d+ +++ ++s+P +l+f++ ++
  EFC38014.1   8 EQLSTKYPNT--------NFVSVDVDQSQDIASQYSVSSLPTFLFFKAGSK 50 
                 4444444444........5****************************9543 PP

>> HyaE  Hydrogenase-1 expression protein HyaE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   6.5e-07    0.0023      61     101 ..      18      56 ..       7      64 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 6.5e-07
                 -EEEEEETHHHHHHHHHCCT-TSSSEEEEEETTEEEEEEES CS
        HyaE  61 lraavvadreqeealaerfgvlktPsllflrdgeylgvlak 101
                     v  d +q++ +a+++ v+  P++lf++ g+ lg + +
  EFC38014.1  18 NF--VSVDVDQSQDIASQYSVSSLPTFLFFKAGSKLGQIVG 56 
                 33..334789***************************9865 PP

>> Phosducin  Phosducin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   1.2e-05     0.043     171     223 ..      10      63 ..       5      94 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.2e-05
                 HHHH-TTSEEEEEEHHH.H--TTSS-TTT-SEEEEEETTEEEEEETTGGGGS-T CS
   Phosducin 171 laaeyptvkfckvkasv.igasdrfsrdvlpallvykagellsnfvrvtdqlae 223
                 l+++yp   f  v   +    ++++s   lp++l +kag  l+++v    +  e
  EFC38014.1  10 LSTKYPNTNFVSVDVDQsQDIASQYSVSSLPTFLFFKAGSKLGQIVGADMDKVE 63 
                 7789******99987541567899*******************99976555555 PP

>> Thioredoxin_2  Thioredoxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   5.7e-05       0.2      61      99 ..      17      57 ..       2      66 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.7e-05
  Thioredoxin_2 61 kafkd..ieenvelarkygvrgtPtivfldgkeivarlpGy 99
                   ++f    ++++++ a +y v+++Pt++f+ +  ++ +++G+
     EFC38014.1 17 TNFVSvdVDQSQDIASQYSVSSLPTFLFFKAGSKLGQIVGA 57
                   333336678899999**********7766666477777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       430  (0.0239835); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.44u 0.30s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 983.80
//
Query:       EFC38015.1  [L=335]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       962  (0.0536561); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2111.53
//
Query:       EFC38016.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.3e-14   51.3   0.0    1.7e-13   50.5   0.0    1.4  1  Ras       Ras family
    7.4e-07   29.4   0.0    1.7e-06   28.2   0.0    1.6  1  Roc       Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.5   0.0   1.9e-17   1.7e-13       1     150 [.     158     312 ..     158     320 .. 0.84

  Alignments for each domain:
  == domain 1  score: 50.5 bits;  conditional E-value: 1.9e-17
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHH...HHHHHHTTESEEEEEEETTBHHHHHTHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefks...lrelyyrdaegillvyditsresfenvkkwvee 96 
                 K  ++G++ vGK+ +  +f+++ ++ +  + ig+df ++++++ + ++k ++w     +  k+   ++++++++a+ ++  ++i++r sf++++k++  
  EFC38016.1 158 KYAIIGNKKVGKSRFFRSFASGCYSPHLLPNIGADFIVRDCDFLNFKLKHQVWHGSILNYAKTtgiVARSFLHSASILVFSFSIDNRCSFTDISKYWIP 256
                 789**************************************************9875443322222567788888888889*************77777 PP

                 HHHHSTTTSEEEEEEETTTGGG.G-SS-HHHHHHHH.HHHTSEEEEEBTTTTCTHH CS
         Ras  97 ikrvaeenvpivLvGnKvDlee.kravsteegeela.kelglkfletSAktnenve 150
                 + ++   n++ +L+G     e+ +r+v+++e+ ela +e++  ++e+ A + +n++
  EFC38016.1 257 LWKQFAPNTVAILLGFYPREEKfTRQVTQQEACELAiNEFNSIYVEVNAAQMQNIN 312
                 766666678888999766555559**********9967888**********99997 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   0.0   1.9e-10   1.7e-06       1     115 [.     158     271 ..     158     272 .. 0.79

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 1.9e-10
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTT...T-HHHHCTSCEEEEEEE..GH.HHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrs...lhplylreaalailvyd..sr.sse 93 
                 K  ++G+++vGK+ ++++f ++ +s++  + ig+df+ +++  ++         k+k ++W  +  +  ++   +++++l++a+++++ +   +r s++
  EFC38016.1 158 KYAIIGNKKVGKSRFFRSFASGCYSPHLLPNIGADFIVRDCDFLNF--------KLKHQVWHGSILNYAKTtgiVARSFLHSASILVFSFSidNRcSFT 248
                 6689**********************************99854432........36679998776555554223789**********988643553455 PP

                 CH.HHHHHHHHHHCSSS-EEEEE CS
         Roc  94 nl.keWlkelkkvagkspvilvg 115
                 ++ k+W+   k+ a+++++il+g
  EFC38016.1 249 DIsKYWIPLWKQFAPNTVAILLG 271
                 44399***********9999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       543  (0.0302861); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 2017.55
//
Query:       EFC38017.1  [L=403]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.77    9.6   9.4      0.072   12.9   0.9    3.3  3  LEAP-2    Liver-expressed antimicrobial peptide 2 precursor (


Domain annotation for each model (and alignments):
>> LEAP-2  Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0     0.087   1.6e+03      47      61 ..      28      42 ..      26      46 .. 0.86
   2 ?   -0.6   0.7     0.067   1.2e+03      46      62 ..     193     209 ..     164     224 .. 0.73
   3 ?   12.9   0.9     4e-06     0.072      48      71 ..     228     252 ..     223     257 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.087
      LEAP-2 47 lrPiGascrddseci 61
                 r +G sc  d +c+
  EFC38017.1 28 YRYLGDSCEIDGQCL 42
                5889********997 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.067
      LEAP-2  46 slrPiGascrddsecit 62 
                  +   G sc  ds+c  
  EFC38017.1 193 NVPSYGDSCVIDSDCAF 209
                 55567999999999965 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 4e-06
      LEAP-2  48 rPiGascrddsecitrlcr.krrcs 71 
                  P+G sc+ + ec t  c   +rc 
  EFC38017.1 228 TPLGGSCKQNDECYTSYCStSKRCE 252
                 59****************7257885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (403 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       781  (0.0435607); expected 358.6 (0.02)
Passed bias filter:                      313  (0.0174578); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2427.92
//
Query:       EFC38018.1  [L=1418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.39   10.7   5.2       0.35   10.8   1.9    2.8  2  RUN       RUN domain


Domain annotation for each model (and alignments):
>> RUN  RUN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1      0.35   6.3e+03      28      63 ..     134     168 ..      75     175 .. 0.69
   2 ?   10.8   1.9   1.9e-05      0.35       3     132 ..    1279    1411 ..    1186    1413 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.35
         RUN  28 kkessfwallekvakllteaesllsavqelealhss 63 
                 k+++++ ++   +++ +++++sl+sa+ +l + +++
  EFC38018.1 134 KETREYEQP-ITIEPSISTHDSLTSAIPNLANWDKE 168
                 334444444.34567788888888888888877776 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 1.9e-05
         RUN    3 caaleal.lshGLrrssesllralglkkessfwallekvakllteaesllsavqelealhsskk.....rsadgk.frawirlaLnekkLskwlelL 92  
                  c  +e+l l h L +       ++ l++++   +++  ++ l+++ + +++++++ ++++  kk     +++d+  +++++ +  ++ +++  +  L
  EFC38018.1 1279 CVSIENLlLDHRLEK-------KAFLTNKPYKESPVTIMKGLSPQGDAIVKEFNKFIDVSGIKKklpndVHKDSNlAHLLVQFCFHKDVMTTLILQL 1368
                  444444313455553.......444555555555555555566666666666666666666655777775555444899999999*****9988887 PP

         RUN   93 ..vsnaellssyYer.ealvadpefgsillslLvglsaldfsl 132 
                    +s  + l++yY++ ++l+ ++ ++++l+ +++ l++l+ ++
  EFC38018.1 1369 thFSTLSYLKKYYDPtTSLLLNTSYRDELSATIELLKQLKLTF 1411
                  23455568******9459********************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2800  (0.156172); expected 358.6 (0.02)
Passed bias filter:                      572  (0.0319036); expected 358.6 (0.02)
Passed Vit filter:                       195  (0.0108762); expected 17.9 (0.001)
Passed Fwd filter:                        56  (0.00312343); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.76u 0.36s 00:00:02.12 Elapsed: 00:00:00.60
# Mc/sec: 7067.79
//
Query:       EFC38019.1  [L=199]
Description: hypothetical protein NAEGRDRAFT_74247 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.3e-16   59.7   0.0    5.8e-16   58.4   0.0    1.7  1  COMM_domain  COMM domain
  ------ inclusion threshold ------
      0.044   14.7   0.4       0.13   13.2   0.1    1.9  2  CSN5_C       Cop9 signalosome subunit 5 C-terminal domain
       0.12   12.9   0.3        1.1    9.9   0.1    2.1  2  RusA         Endodeoxyribonuclease RusA


Domain annotation for each model (and alignments):
>> COMM_domain  COMM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.4   0.0   9.7e-20   5.8e-16       2      69 ..     131     194 ..     130     195 .. 0.97

  Alignments for each domain:
  == domain 1  score: 58.4 bits;  conditional E-value: 9.7e-20
  COMM_domain   2 pqLvdldWrldvqlsssslskvneptalleLklqngsgnsenvtlelskeqLqeLlneLeeiqkqles 69 
                  p +v+ldWrld++l++s+l++v+ep+++l++k ++g++     t+ +++eqLq+L ++++++ kq+e+
   EFC38019.1 131 PEIVQLDWRLDYVLKTSELKQVHEPVYTLRFKCKDGQE----ATISCNAEQLQDLHSKIRDATKQVER 194
                  899********************************999....***********************996 PP

>> CSN5_C  Cop9 signalosome subunit 5 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.2     7e+03      62      81 ..      35      54 ..       9      56 .. 0.68
   2 ?   13.2   0.1   2.2e-05      0.13      13      34 ..     175     196 ..     173     199 .] 0.89

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.2
      CSN5_C 62 kvvkdstkiaseaqhGLiaq 81
                 + k stk  se+ + +i++
  EFC38019.1 35 SILKTSTKPLSEQIQEMISN 54
                45666777777777776665 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 2.2e-05
      CSN5_C  13 tkqisDLaeKlekaessvsrsr 34 
                 ++q++DL++K+++a+++v+r+ 
  EFC38019.1 175 AEQLQDLHSKIRDATKQVERTF 196
                 68****************9986 PP

>> RusA  Endodeoxyribonuclease RusA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0     0.099   5.9e+02      37      76 ..      16      54 ..       6      84 .. 0.73
   2 ?    9.9   0.1   0.00018       1.1      11      51 ..      97     134 ..      94     165 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.099
                HHTT-..TT-B-S-EEEEEEEE-SS............... CS
        RusA 37 ekqyekdkeplegplkvevtlyfpipkslskkkkqealek 76
                e+qy  d++++++ + v++  ++++ ++   ++ qe++++
  EFC38019.1 16 EDQY-FDEQTFKQLVNVSILSILKTSTKPLSEQIQEMISN 54
                5666.37788888888888888887766666666666655 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00018
                 HEEESSSSEEE-HHHHHHHHHHHHHHHHTT-..TT-B-S-E CS
        RusA  11 rlrkkggrtytpkktkayeeevkaylekqyekdkeplegpl 51 
                 ++++++   y+++++++y++++++++ kq+   + ++ + +
  EFC38019.1  97 HFVNRQRLNYLSQEYETYKKDIRECVLKQK---TFSFPEIV 134
                 577888899********************9...33333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (199 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1382  (0.0770818); expected 358.6 (0.02)
Passed bias filter:                      644  (0.0359195); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1277.86
//
Query:       EFC38020.1  [L=324]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.053   14.0   6.4        3.6    8.2   0.6    3.7  4  LRR_4     Leucine Rich repeats (2 copies)
      0.071   13.0   0.1       0.46   10.4   0.1    2.3  2  DUF2536   Protein of unknown function (DUF2536)
      0.087   12.9   0.3       0.98    9.6   0.1    2.6  2  UvsW      ATP-dependant DNA helicase UvsW
       0.32   10.8   2.8        6.7    6.6   0.5    3.2  2  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       2.5   1.1e+04      23      30 ..     143     150 ..     130     155 .. 0.58
   2 ?    8.2   0.6    0.0008       3.6      19      39 ..     183     198 ..     168     210 .. 0.76
   3 ?    6.3   0.1    0.0031        14       2      30 ..     213     240 ..     212     244 .. 0.88
   4 ?   -0.5   0.0      0.43   1.9e+03      24      33 ..     290     298 ..     281     309 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.5
                 TT--EEE- CS
       LRR_4  23 pnLkeLdL 30 
                   Lk+L L
  EFC38020.1 143 STLKYLVL 150
                 33666655 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0008
                 HHH-TT--EEE-.-S-----G CS
       LRR_4  19 leklpnLkeLdLsgNnlitdl 39 
                 l+ +++Lk+L++ +N    ++
  EFC38020.1 183 LN-MKQLKYLYIEDN----SI 198
                 56.*********776....32 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0031
                 S--EEE--SS---E-S-HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdL 30 
                 nLe+L + + ++ +i+ +  lp+LkeL L
  EFC38020.1 213 NLEKLEIVSYHINEIEKFH-LPKLKELGL 240
                 89999999559********.******966 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.43
                 T--EEE-.-S CS
       LRR_4  24 nLkeLdLsgN 33 
                 +Lk+L++ +N
  EFC38020.1 290 KLKSLTI-EN 298
                 5788887.66 PP

>> DUF2536  Protein of unknown function (DUF2536)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.56   2.5e+03       3      20 ..      48      65 ..      47      74 .. 0.77
   2 ?   10.4   0.1    0.0001      0.46      10      34 ..     114     138 ..     111     153 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.56
     DUF2536  3 fqldliedKvEfFEAedl 20
                f+ ++i  KvE+   ed+
  EFC38020.1 48 FHCEMIRPKVEIGKREDF 65
                6789999***98766666 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.0001
     DUF2536  10 dKvEfFEAedlkeLEkkineqienN 34 
                 + vE FE + lk LE ki++ i +N
  EFC38020.1 114 QYVELFESRILKRLEFKISDFIPEN 138
                 569****************988777 PP

>> UvsW  ATP-dependant DNA helicase UvsW
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       0.4   1.8e+03      16      23 ..      75      82 ..      73      85 .. 0.87
   2 ?    9.6   0.1   0.00022      0.98      10      40 ..     224     261 ..     223     265 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.4
                HHHHHTTT CS
        UvsW 16 lYkkkkKE 23
                 Y+k++KE
  EFC38020.1 75 CYTKQVKE 82
                59*****9 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00022
                 HHHHHHHHHHHTTT......S--...TTHHHHHHHHHH CS
        UvsW  10 lvElEklYkkkkKElG....ael...kdtdDIrVRDAl 40 
                 + E+Ek+   k KElG      +     +dDI+VR  l
  EFC38020.1 224 INEIEKFHLPKLKELGlihpMSVhwqHSMDDISVRNVL 261
                 579************943331222224689*****876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.37   1.7e+03      25      34 ..     143     152 ..     131     174 .. 0.66
   2 ?    6.6   0.5    0.0015       6.7      23      39 ..     184     200 ..     179     221 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.37
                 TT--EEE--S CS
       LRR_8  25 snLkvLdLsn 34 
                 s Lk+L L++
  EFC38020.1 143 STLKYLVLRE 152
                 4555555543 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0015
                 T-TT--EEE--SS---G CS
       LRR_8  23 glsnLkvLdLsnNlltt 39 
                 ++++Lk+L++ +N+++ 
  EFC38020.1 184 NMKQLKYLYIEDNSINN 200
                 78999999999999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (324 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       713  (0.039768); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1914.29
//
Query:       EFC38021.1  [L=854]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-41  140.9 173.9    1.2e-05   25.6   7.5   11.8 11  EGF_2         EGF-like domain
    1.9e-19   68.6   0.3     0.0033   17.4   0.0    7.2  7  NHL           NHL repeat
    0.00084   19.6   4.1    0.00084   19.6   4.1   13.2 12  EGF           EGF-like domain
     0.0058   16.2   0.4        1.4    8.5   0.0    3.2  3  SGL           SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.017   15.3   0.0        5.1    7.4   0.0    3.9  4  Arylesterase  Arylesterase
        0.4   10.5   6.2      0.064   13.0   1.3    2.4  2  DUF4408       Domain of unknown function (DUF4408)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   7.6   3.9e-06     0.012       7      32 .]      40      64 ..      35      64 .. 0.88
   2 !   16.1  11.2   3.5e-06     0.011       7      32 .]     437     463 ..     430     463 .. 0.90
   3 !   20.7   9.1   1.3e-07    0.0004       6      32 .]     477     502 ..     472     502 .. 0.93
   4 !   25.6   7.5     4e-09   1.2e-05       6      32 .]     516     541 ..     511     541 .. 0.92
   5 !   17.6   7.4   1.2e-06    0.0036       5      32 .]     554     580 ..     550     580 .. 0.85
   6 !   22.5   8.7   3.6e-08   0.00011       6      32 .]     594     619 ..     590     619 .. 0.88
   7 !   14.0  10.2   1.6e-05     0.048       6      32 .]     633     659 ..     624     659 .. 0.86
   8 !   19.3   8.7   3.6e-07    0.0011       4      32 .]     670     698 ..     664     698 .. 0.89
   9 !   20.9   8.9   1.1e-07   0.00034       6      32 .]     712     737 ..     708     737 .. 0.90
  10 !   20.3  10.5   1.8e-07   0.00053       5      32 .]     750     776 ..     746     776 .. 0.90
  11 !   11.1   4.1   0.00013       0.4       6      32 .]     790     815 ..     781     815 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 3.9e-06
       EGF_2  7 iCgghGtCvnqcGqCdCdsgyqGktC 32
                 C+g+G C + +  C+C+ gy+G  C
  EFC38021.1 40 VCSGNGLCQANN-ACSCNVGYFGSEC 64
                5*******8555.8************ PP

  == domain 2  score: 16.1 bits;  conditional E-value: 3.5e-06
       EGF_2   7 iCgghGtCvnqcGqCdC..dsgyqGktC 32 
                  C+g+G C + + qC+C  d gy+G +C
  EFC38021.1 437 VCSGRGNCTTHN-QCSCnvDEGYYGENC 463
                 6*******9555.*************** PP

  == domain 3  score: 20.7 bits;  conditional E-value: 1.3e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G+C +++ +C C++gy+G +C
  EFC38021.1 477 SVCSGNGVCSSLE-NCTCSTGYYGTNC 502
                 68********9**.8************ PP

  == domain 4  score: 25.6 bits;  conditional E-value: 4e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG+Cv+++ +C+C++gy+G +C
  EFC38021.1 516 SVCSAHGKCVTFN-NCSCNTGYFGQSC 541
                 57********888.8************ PP

  == domain 5  score: 17.6 bits;  conditional E-value: 1.2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hG C +  + C C++gy+G+ C
  EFC38021.1 554 SLVCSSHGLCTDY-NTCNCSNGYYGAAC 580
                 789*******744.49************ PP

  == domain 6  score: 22.5 bits;  conditional E-value: 3.6e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghG+C +   qC C++gy+G++C
  EFC38021.1 594 SVCSGHGKCLQVD-QCLCQDGYYGANC 619
                 57*******9555.9************ PP

  == domain 7  score: 14.0 bits;  conditional E-value: 1.6e-05
       EGF_2   6 eiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 + C+ +G+C + + +C+C   gy+G+tC
  EFC38021.1 633 TVCSARGICSSYN-NCSCqLEGYYGATC 659
                 57*******9555.8************* PP

  == domain 8  score: 19.3 bits;  conditional E-value: 3.6e-07
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ hG+C +++ +C C+ gy+G +C
  EFC38021.1 670 NaESVCSAHGICSSFN-NCTCFIGYSGSDC 698
                 35789********999.8************ PP

  == domain 9  score: 20.9 bits;  conditional E-value: 1.1e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ hG+C + + +C C+ gy+G +C
  EFC38021.1 712 STCSSHGICSSHN-NCTCSKGYYGSKC 737
                 58*******9666.8************ PP

  == domain 10  score: 20.3 bits;  conditional E-value: 1.8e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ghG C +++ +C C +gy+G++C
  EFC38021.1 750 SRVCSGHGFCSSFN-NCTCLDGYYGNNC 776
                 568********999.8************ PP

  == domain 11  score: 11.1 bits;  conditional E-value: 0.00013
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 e C+  G+C++++ +C C ++ +G +C
  EFC38021.1 790 EVCSSIGICIDKN-VCLCLNNTSGEKC 815
                 68*******9999.************9 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   1.1e-06    0.0033       1      23 [.      96     118 ..      96     122 .. 0.89
   2 !    7.2   0.0    0.0018       5.5       3      22 ..     154     175 ..     152     177 .. 0.90
   3 !   11.0   0.0   0.00012      0.36       1      25 [.     210     234 ..     210     236 .. 0.88
   4 ?   -3.1   0.1       3.5   1.1e+04       7      16 ..     272     281 ..     272     284 .. 0.81
   5 !   17.3   0.0   1.1e-06    0.0034       1      27 [.     322     348 ..     322     349 .. 0.94
   6 !    5.9   0.0    0.0047        14      14      27 ..     394     407 ..     391     408 .. 0.91
   7 ?   -2.1   0.0       1.6   4.9e+03       2      10 ..     675     683 ..     675     686 .. 0.78

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.1e-06
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +++P+Gvav+ +G++y +Ds n+
  EFC38021.1  96 LSSPQGVAVSESGEVYLSDSTNN 118
                 679****************7776 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0018
                 SEEEEEEE.TTTEEEEEE.CCC CS
         NHL   3 yPhGvavd.snGdiyVaD.sen 22 
                 +P+G++++ sn d+y+aD ++n
  EFC38021.1 154 SPQGLSLSpSNSDLYIADtFNN 175
                 5*****************7666 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00012
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 fn  +G+++++nG+++ +D+en+ +
  EFC38021.1 210 FNVIRGLCLSPNGELIFTDTENNMI 234
                 67789*****************855 PP

  == domain 4  score: -3.1 bits;  conditional E-value: 3.5
                 EEEETTTEEE CS
         NHL   7 vavdsnGdiy 16 
                 +av+s+ d++
  EFC38021.1 272 IAVNSDLDVF 281
                 79**888875 PP

  == domain 5  score: 17.3 bits;  conditional E-value: 1.1e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P G++v+s+G+ + aDs+n+r+++
  EFC38021.1 322 LSSPKGLVVSSSGEMFLADSGNNRIRK 348
                 679**********************86 PP

  == domain 6  score: 5.9 bits;  conditional E-value: 0.0047
                 EEEEEECCCTEEEE CS
         NHL  14 diyVaDsenhrvqv 27 
                 +iy++D +nh +++
  EFC38021.1 394 EIYISDAGNHAIRK 407
                 69*********987 PP

  == domain 7  score: -2.1 bits;  conditional E-value: 1.6
                 SSEEEEEEE CS
         NHL   2 nyPhGvavd 10 
                 +++hG++ +
  EFC38021.1 675 CSAHGICSS 683
                 789****87 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   3.2    0.0009       2.7       4      31 ..      37      62 ..      34      63 .. 0.83
   2 ?   -2.4   6.5       2.2   6.6e+03       6      32 .]     438     462 ..     430     462 .. 0.76
   3 !    5.7   8.7    0.0061        18       6      31 ..     479     500 ..     463     501 .. 0.88
   4 !    9.5   3.8   0.00042       1.2       4      30 ..     514     538 ..     511     540 .. 0.89
   5 !   10.7   3.7   0.00017      0.52       5      30 ..     553     577 ..     550     578 .. 0.86
   6 !   19.6   4.1   2.8e-07   0.00084       3      32 .]     591     618 ..     589     618 .. 0.92
   7 !    6.6   2.6    0.0033        10       4      31 ..     631     657 ..     628     658 .. 0.86
   8 !    6.0   4.7     0.005        15       6      31 ..     675     696 ..     660     697 .. 0.83
   9 !   12.5   5.3   4.8e-05      0.14       4      31 ..     710     735 ..     707     736 .. 0.87
  10 !    5.8   7.2    0.0059        18       5      32 .]     749     775 ..     746     775 .. 0.82
  11 ?    0.9   0.4       0.2     6e+02       4      14 ..     774     783 ..     774     785 .. 0.84
  12 ?    0.7   3.4      0.23   6.8e+02       5      31 ..     789     813 ..     786     818 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0009
                TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF  4 np..CsngGtCvdtgrggytCiCpeGytGk 31
                 p  Cs++G C  +      C C +Gy+G+
  EFC38021.1 37 EPavCSGNGLCQANN----ACSCNVGYFGS 62
                5677*******6666....9********96 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.2
                 STTT-EEEEETTTEEEEEEC..TTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCp..eGytGkr 32 
                 Cs++G C     ++ +C C   eGy G++
  EFC38021.1 438 CSGRGNC----TTHNQCSCNvdEGYYGEN 462
                 99*****....66668***9667799986 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0061
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C +++    +C+C++Gy G 
  EFC38021.1 479 CSGNGVCSSLE----NCTCSTGYYGT 500
                 *******9999....********995 PP

  == domain 4  score: 9.5 bits;  conditional E-value: 0.00042
                 TT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytG 30 
                 +p  Cs +G+Cv+      +C C +Gy+G
  EFC38021.1 514 DPsvCSAHGKCVTFN----NCSCNTGYFG 538
                 7888*******9999....********99 PP

  == domain 5  score: 10.7 bits;  conditional E-value: 0.00017
                 T...STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytG 30 
                     Cs +G C d+     tC C++Gy G
  EFC38021.1 553 DslvCSSHGLCTDYN----TCNCSNGYYG 577
                 3444***********....********99 PP

  == domain 6  score: 19.6 bits;  conditional E-value: 2.8e-07
                 STT..STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCpeGytGkr 32 
                 +np  Cs++G+C+++     +C C+ Gy G++
  EFC38021.1 591 DNPsvCSGHGKCLQVD----QCLCQDGYYGAN 618
                 599*************....*********975 PP

  == domain 7  score: 6.6 bits;  conditional E-value: 0.0033
                 TT..STTT-EEEEETTTEEEEEEC.TTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCp.eGytGk 31 
                 +p  Cs +G+C ++     +C C+ eGy G+
  EFC38021.1 631 DPtvCSARGICSSYN----NCSCQlEGYYGA 657
                 5678*******8888....9*********97 PP

  == domain 8  score: 6.0 bits;  conditional E-value: 0.005
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G+C    +   +C+C +Gy+G+
  EFC38021.1 675 CSAHGIC----SSFNNCTCFIGYSGS 696
                 *******....5777**********7 PP

  == domain 9  score: 12.5 bits;  conditional E-value: 4.8e-05
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 np  Cs +G+C    + + +C+C+ Gy G+
  EFC38021.1 710 NPstCSSHGIC----SSHNNCTCSKGYYGS 735
                 7888*******....6888*********96 PP

  == domain 10  score: 5.8 bits;  conditional E-value: 0.0059
                 T...STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGkr 32 
                     Cs++G+C    +   +C+C  Gy G++
  EFC38021.1 749 DsrvCSGHGFC----SSFNNCTCLDGYYGNN 775
                 3446*******....5777**********86 PP

  == domain 11  score: 0.9 bits;  conditional E-value: 0.2
                 TTSTTT-EEEE CS
         EGF   4 npCsngGtCvd 14 
                 n+C+n  tC+d
  EFC38021.1 774 NNCQNF-TCFD 783
                 79****.5*98 PP

  == domain 12  score: 0.7 bits;  conditional E-value: 0.23
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                 p  Cs  G+C+d       C C +  +G+
  EFC38021.1 789 PevCSSIGICIDKN----VCLCLNNTSGE 813
                 555*******9998....89998776665 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.22   6.6e+02     134     171 ..      97     133 ..      90     146 .. 0.66
   2 !    8.5   0.0   0.00045       1.4     128     165 ..     147     184 ..     102     190 .. 0.76
   3 ?    3.5   0.1     0.016        46      94     214 ..     219     353 ..     215     368 .. 0.64

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.22
         SGL 134 tipNGlawspdgktlYlaDsltrkiwaydvdaeggkls 171
                 + p G+a+s+ g  +Yl Ds+++ i ++ ++ + +++ 
  EFC38021.1  97 SSPQGVAVSESG-EVYLSDSTNNIIRKVYLNGTIQTIA 133
                 556666666655.4788888888887777666655555 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00045
         SGL 128 rvlddltipNGlawspdgktlYlaDsltrkiwaydvda 165
                  v  ++  p Gl +sp ++ lY+aD+ ++ + + d+++
  EFC38021.1 147 AVNCQFFSPQGLSLSPSNSDLYIADTFNNVVRRLDLNT 184
                 5667788899**********************999864 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.016
         SGL  94 dpdGrlwfGtmgdeeakgeevgalyrldpdgklervl.dd.......ltipNGlawspdgktlYlaDsltrkiwaydvdae..ggklsnrrvf.adlkk 181
                 +p+G+l+f++ +++  ++    +ly ++++g+++  l d+       l+ip  +a+++d + ++ +Dsl++ + +++ ++   +  ++    f  d   
  EFC38021.1 219 SPNGELIFTDTENNMIRKVYANGLYDVSGRGQTNSYLgDGglginawLGIPYQIAVNSDLDVFF-VDSLYNVVRRIKQSSGiiNAVIGTGSGFgGD--- 313
                 7889999999999998888889999999995544333133222222255666678888877665.7888888887776422112223333333222... PP

         SGL 182 ge........gepDGlavDaeGnvwvAvwgggkvvrfdpdG 214
                  +        + p Gl+v ++G+++ A  g+++++++  +G
  EFC38021.1 314 -GgqatsaqlSSPKGLVVSSSGEMFLADSGNNRIRKVFSNG 353
                 .1445577776688888888888888888888888776666 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.44   1.3e+03      52      78 ..      95     120 ..      84     126 .. 0.81
   2 ?    7.4   0.0    0.0017       5.1      41      79 ..     140     178 ..     122     184 .. 0.84
   3 ?   -1.2   0.0      0.82   2.5e+03      51      76 ..     320     344 ..     312     348 .. 0.76
   4 ?    1.7   0.0     0.099   2.9e+02      40      71 ..     661     692 ..     651     696 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.44
  Arylesterase  52 glssanGInidadkkyiyvadilresi 78 
                    lss+ G+ ++     +y++d++++ i
    EFC38021.1  95 MLSSPQGVAVSESG-EVYLSDSTNNII 120
                   5899*****99776.589999998765 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0017
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresih 79 
                   ys+++   v  ++ s+ G+ +++ +  +y+ad  ++ + 
    EFC38021.1 140 YSGDNGPAVNCQFFSPQGLSLSPSNSDLYIADTFNNVVR 178
                   888999999999********************9988765 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.82
  Arylesterase  51 sglssanGInidadkkyiyvadilre 76 
                   ++lss+ G+++++    +++ad+ ++
    EFC38021.1 320 AQLSSPKGLVVSSSGE-MFLADSGNN 344
                   6799*******99875.467776555 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.099
  Arylesterase  40 YyspsevkvvasglssanGInidadkkyiyva 71 
                   +y+  ++++ a+++ sa GI  + ++   +++
    EFC38021.1 661 HYNCFDISKNAESVCSAHGICSSFNNCTCFIG 692
                   678889999***********999888877776 PP

>> DUF4408  Domain of unknown function (DUF4408)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   1.3   2.2e-05     0.064      18      31 ..     349     362 ..     349     363 .. 0.95
   2 ?   -3.2   0.3       2.5   7.5e+03      22      30 ..     843     851 ..     843     851 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.2e-05
     DUF4408  18 vvlNlIIvtIvaeS 31 
                 v++N IIvtI+++S
  EFC38021.1 349 VFSNGIIVTIAGTS 362
                 8************9 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.5
     DUF4408  22 lIIvtIvae 30 
                 ++Iv+++ +
  EFC38021.1 843 IMIVFLWLT 851
                 699**9965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (854 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       778  (0.0433934); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.80u 0.31s 00:00:01.11 Elapsed: 00:00:00.53
# Mc/sec: 4820.40
//
Query:       EFC38022.1  [L=861]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.9e-52  177.6   6.6    3.2e-35  121.8   0.8    2.3  2  Pkinase         Protein kinase domain
      2e-26   92.8   0.4    5.5e-19   68.5   0.3    2.2  2  Pkinase_Tyr     Protein tyrosine kinase
    0.00028   19.8   1.4    0.00036   19.4   0.1    1.7  2  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.016   14.8   1.1        2.5    7.7   0.1    2.8  2  FTA2            Kinetochore Sim4 complex subunit FTA2
      0.024   14.0   0.3        0.1   11.9   0.1    2.1  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.8   0.5   1.5e-19   5.3e-16       3     198 ..     217     422 ..     215     506 .. 0.77
   2 !  121.8   0.8     9e-39   3.2e-35       7     213 ..     564     778 ..     560     818 .. 0.80

  Alignments for each domain:
  == domain 1  score: 58.8 bits;  conditional E-value: 1.5e-19
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH........HHS CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle........rkg 93 
                  ++ lG  + G+V+k++ k+++   A+K   + +++++     +rE+  l k++ +  ++++e+ +   +ly v+e+ e ++l d+++        r+g
  EFC38022.1 217 FISILGYEGEGTVFKVFLKKSKTLRAIKLKYEAEKNEE----STRELIKLLKTDIEGKIKYFECDTIGGHLYSVMELGE-QSLSDYITrnneegfyRDG 310
                 5677888889*****************97555544443....579**99*****************************9.6699999988777776666 PP

                 S--HH...HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.......TTSCBSHHHHHHH CS
     Pkinase  94 slsee...eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl.......keneyskkvDvWs 182
                  +s++   e+ +i+ ++l++++ + ++  +HrDl p+Ni    ++  Ki+ F  ak ++s       v    Y++PE l       ++++  ++  ++s
  EFC38022.1 311 FISKDkiiEIIEIFIKVLTSVSSINEHYTLHRDLDPKNIVKV-QDYYKIINFNTAKAIDSYP--LMAVRKVPYMPPESLveaprngNNQKQINNGHLFS 406
                 666667777789999************************999.999*************976..67788899*******99998743344478889*** PP

                 HHHHHHHHHHSS-STT CS
     Pkinase 183 lGvilyelltgkppfs 198
                 lG+il++l+t++p+  
  EFC38022.1 407 LGCILLKLFTNCPLQL 422
                 ********99987643 PP

  == domain 2  score: 121.8 bits;  conditional E-value: 9e-39
                 EEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEE...EEEESSEEE.EEEE--TTEBHHHHHHHHSS--HHHHH CS
     Pkinase   7 lGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlye...vfeekdely.lvleyveggeladllerkgslseeeak 101
                 +G G+ G+V k+++k+ g+ivA+K+ +++++ ++  +++++  k  k+++hpn+vr++e   v+++ d++y +++e++e+ +l++++e +++ls +e+ 
  EFC38022.1 564 IGCGK-GVVDKVMDKKLGRIVALKTYRESSIMNDL-TRLMEAFKKAKEFDHPNVVRYLEydvVYQSLDNFYfVIMELAEQ-NLKQYIESQRNLSLKEIT 659
                 66665.9**********************999876.5899999**************76333355566666378999985.5***************** PP

                 HHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE..TTTE...EEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH....TTSCBSHHHHHHHHHHHHHHH CS
     Pkinase 102 kiakqilegleylHskgiiHrDlKpeNiLid..ekge...lKitDFGlakelesssk.ltsfvgtseYlAPEvl....keneyskkvDvWslGvilyel 190
                  +++ il+g  ylH++giiHrDlKp+NiLi   e  +    +i+D + +k ++ +   +t + gt+eY APE+     ++n+  + vD++slG+i + +
  EFC38022.1 660 MLFRDILKGCIYLHQNGIIHRDLKPQNILIYriE--DkvvPRISDHDECKIADLDLVrTTLVQGTREYAAPELFektrSNNNLYERVDIYSLGCIYLFM 756
                 ******************************9433..23479*********9999876578889***********9986668889***********9999 PP

                 HHSS-STTTSSHHHHHHHHHHTH CS
     Pkinase 191 ltgkppfsgekgkekvekeldql 213
                 l ++ +   e+++   +++l+q 
  EFC38022.1 757 LINTDLEV-EEKTFFDWMILNQE 778
                 98877655.33333344555554 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.0   2.1e-08   7.4e-05      13     200 ..     227     416 ..     216     439 .. 0.76
   2 !   68.5   0.3   1.5e-22   5.5e-19      25     195 ..     577     753 ..     562     790 .. 0.80

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 2.1e-08
                  EEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT.........CTTTSB CS
  Pkinase_Tyr  13 GkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk.........ekeklt 101
                  G+V++  lk    k+++  a+K     +++e++ee ++e+  + k++ +  +k+  + t +++l+ v+e+ ++ +L+++++++           +k +
   EFC38022.1 227 GTVFKVFLK----KSKTLRAIKLK---YEAEKNEESTRELIKLLKTDIEGKIKYFECDTIGGHLYSVMELGEQ-SLSDYITRNneegfyrdgFISKDK 316
                  666666666....45555566654...5555567888999999999999999*******9*********9876.9********999999887455556 PP

                  HHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.......EEHHHHHHHHH CS
  Pkinase_Tyr 102 lkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.......ftsksDvWsfG 192
                  + +++++ ++v   ++ ++++  +Hrdl  +N+ ++ ++  ki  f  a++i   d+y     a   v +m+pEsl e            +   +s G
   EFC38022.1 317 IIEIIEIFIKVLTSVSSINEHYTLHRDLDPKNI-VKVQDYYKIINFNTAKAI---DSYPLM--AVRKVPYMPPESLVEAPrngnnqkQINNGHLFSLG 408
                  7889999*************************9.67799*************...444433..44567799**9997654333333244455566666 PP

                  HHHHHHHT CS
  Pkinase_Tyr 193 vllwEift 200
                   +l  +ft
   EFC38022.1 409 CILLKLFT 416
                  66666666 PP

  == domain 2  score: 68.5 bits;  conditional E-value: 1.5e-22
                  TSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE....SSSS..EEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHH CS
  Pkinase_Tyr  25 ekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct....keep..llivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGm 116
                  +k    Va+Kt +e++  ++ ++l+e  k  k+++hpn+v++l   +          +++++e++++ +L+++++++  ++l+lk+++ +  ++ kG+
   EFC38022.1 577 KKLGRIVALKTYRESSIMNDLTRLMEAFKKAKEFDHPNVVRYLEYDVvyqsL--DnfYFVIMELAEQ-NLKQYIESQ--RNLSLKEITMLFRDILKGC 669
                  555678***********************************98754433422..2447788888765.9******98..9****************** PP

                  HHHHHTTEEEST-SGGGEEEEE......TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE....EEHHHHHHHHHHHH CS
  Pkinase_Tyr 117 eyLeskklvHrdlaarNvLlse......nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk....ftsksDvWsfGvll 195
                   yL+++ ++Hrdl  +N+L+ +          +isD   ++    d + v+++  +   ++ apE +++++    + ++ D++s G + 
   EFC38022.1 670 IYLHQNGIIHRDLKPQNILIYRiedkvvP---RISDHDECKIA--DLDLVRTTLVQGTREYAAPELFEKTRsnnnLYERVDIYSLGCIY 753
                  ********************987764440...56665555544..44555555667778899***999887777788999****99764 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.2      0.37   1.3e+03     307     339 ..     319     350 ..     313     366 .. 0.79
   2 !   19.4   0.1     1e-07   0.00036     304     360 ..     654     715 ..     645     734 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.37
  Pkinase_fungal 307 ellealrDaIkghrsLflkagiLHrDiSenNil 339
                     e++e ++ +++   s   +   LHrD   +Ni+
      EFC38022.1 319 EIIEIFIKVLTSVSSIN-EHYTLHRDLDPKNIV 350
                     66677777777777777.8889*********97 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 1e-07
  Pkinase_fungal 304 spkellealrDaIkghrsLflkagiLHrDiSenNilitdskke......gerkglLiDLDlak 360
                     s ke+   +rD +kg   L+ + gi+HrD   +Nili+  +++      ++++  ++DLDl  
      EFC38022.1 654 SLKEITMLFRDILKGCIYLH-QNGIIHRDLKPQNILIYRIEDKvvprisDHDECKIADLDLVR 715
                     667888899***********.*****************666667889988899999****965 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1    0.0042        15      13      60 ..     204     253 ..     203     283 .. 0.76
   2 ?    7.7   0.1   0.00069       2.5     178     204 ..     662     688 ..     576     694 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0042
        FTA2  13 LkpFdfsaekdiefleyLgkglhsiVlkvkirgk..eYALKlFrfleaee 60 
                 L+ F ++ + d++f+++Lg   ++ V+kv  +++    A+Kl ++ e++e
  EFC38022.1 204 LNLFYNHFKSDYDFISILGYEGEGTVFKVFLKKSktLRAIKLKYEAEKNE 253
                 6779999999**********9********998875567999755554333 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00069
        FTA2 178 lpkllrdlkklhklgIvvrDlkeenyi 204
                 ++++l+    lh+ gI++rDlk++n++
  EFC38022.1 662 FRDILKGCIYLHQNGIIHRDLKPQNIL 688
                 4566666677**************986 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.32   1.2e+03     129     150 ..     329     350 ..     322     364 .. 0.77
   2 ?   11.9   0.1   2.8e-05       0.1     103     170 ..     641     715 ..     595     729 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.32
         Kdo 129 rliaklhragvnHadlyaknil 150
                 + ++ +++    H+dl +kni 
  EFC38022.1 329 TSVSSINEHYTLHRDLDPKNIV 350
                 567777888889*******995 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 2.8e-05
         Kdo 103 qdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqee.......eeeaeiwliDldkar 170
                 q+L++++++ ++l+ +   +l++++ +    lh+ g+ H+dl ++nil+   e       +++ e+ + Dld  r
  EFC38022.1 641 QNLKQYIESQRNLSLKEITMLFRDILKGCIYLHQNGIIHRDLKPQNILIYRIEdkvvpriSDHDECKIADLDLVR 715
                 5677777776667777777778888888888*****************987765677777777777777777555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (861 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       776  (0.0432818); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 5145.03
//
Query:       EFC38023.1  [L=1127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1348  (0.0751855); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.78u 0.28s 00:00:01.06 Elapsed: 00:00:00.45
# Mc/sec: 7556.15
//
Query:       EFC38024.1  [L=414]
Description: delta24(24-1) sterol reductase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   5.3e-114  381.3  25.3   6.3e-114  381.1  25.3    1.1  1  ERG4_ERG24       Ergosterol biosynthesis ERG4/ERG24 family
  ------ inclusion threshold ------
       0.61   10.2   7.1        0.8    9.8   0.0    2.9  2  Chromate_transp  Chromate transporter
        1.4    8.7   5.9       0.15   11.7   0.6    2.2  2  Spore_YhaL       Sporulation protein YhaL
        2.9    8.1   7.4       0.55   10.5   1.9    2.3  2  DUF1516          Protein of unknown function (DUF1516)


Domain annotation for each model (and alignments):
>> ERG4_ERG24  Ergosterol biosynthesis ERG4/ERG24 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  381.1  25.3  1.4e-117  6.3e-114      58     431 ..      31     413 ..       2     414 .] 0.95

  Alignments for each domain:
  == domain 1  score: 381.1 bits;  conditional E-value: 1.4e-117
  ERG4_ERG24  58 llvfegaiwerklftvfllfyvlqavlylllpGkvveGleLs..ngkkLkYkinalaslllvlaillvlqvtelfeltvlidnfvqlisvailfafala 154
                    +e a ++ ++f +++ f v + vl  l+pG   eGl+L+   gkkL Y++na++  +++l ++ +l vt +  + +l+dnf+++++vai+f+ ++a
  EFC38024.1  31 SAAWEIAQPNWTAFNIYMGFIVYEGVLGWLIPGDLYEGLPLEheGGKKLIYNCNAIHVWYITLPLIGILYVTGIAPVSMLYDNFAPILTVAIIFSNLVA 129
                 455666779999*****************************987799**************************************************** PP

  ERG4_ERG24 155 ivlYvrslkvkerkkdkqlaaggvsGnliYDffiGreLnPRlgslDlkmFlelRlgllllllinlaallkqyklygkvtdslllvllaqllYvfdgvkn 253
                 i+ Y  ++ + +         +++sG+ +YDff+G+ LnPRlgslDlkmF+e R++++ll+l++l+a++kqy+  g++t  ++++l a+++Yv++ +k+
  EFC38024.1 130 IFTYFYTIATGN--------EHRLSGSFLYDFFMGAVLNPRLGSLDLKMFTEARISWVLLFLLTLSAAAKQYEELGYITTPMIFMLTAHTIYVNAIMKG 220
                 *******99998........7****************************************************************************** PP

  ERG4_ERG24 254 eeavlttmDittdgFGFmLaFgdlvlvPftYslqtlYLsvhPselgwst.vlvailvvlligyyiFrsansqknnFR...........tnPedpklkl. 339
                 ee v + +Di ++++G++L++++l++vPf+Y+  ++Y++ +  e++++  ++  i ++l+++yy++++a sq+n FR           t+P++p+ +l 
  EFC38024.1 221 EECVPSSWDIFYEKWGWLLIYWNLAGVPFVYCFSSIYIYKKGEEINMPWwYNLCIFILLFVAYYFWDTAQSQRNRFRmkkngtfrerkTFPQLPYGTLp 319
                 *****************************************888887766********************************************99876 PP

  ERG4_ERG24 340 ..lkyiqtktGskLlvsGWyglarkinYlgDwlqslswsLatgfqsvlpyfyvlyFlvlLvhRelRDeekCkkkYGedweeYkkkvpykiipyv 431
                    k ++tk Gs+Llv+GW+++ark+nY+ D ++ l+w L++gf s +pyfy ++F+++++hR  RD+e+Ck+kY edw++Y+ +v+y +ip++
  EFC38024.1 320 dnAKCLKTKAGSELLVDGWWAYARKLNYTMDTTMGLTWGLICGFGSFIPYFYFIFFFCMIIHRYHRDSERCKRKYKEDWDKYCETVKYIFIPGI 413
                 6689****************************************************************************************98 PP

>> Chromate_transp  Chromate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   5.0      0.37   1.6e+03      55     118 ..      40     132 ..      37     289 .. 0.69
   2 ?    9.8   0.0   0.00018       0.8      68     100 ..     353     385 ..     330     394 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.37
  Chromate_transp  55 iavnlatfvGylil.gvlG.........................aliatlgfflPsfllill..laplleklrk.nplvkaaleglnaavvgl 118
                      + + + +++G+ ++ gvlG                           i ++ ++lP + ++++  +ap+   + +  p+++ a+   n +++  
       EFC38024.1  40 NWTAFNIYMGFIVYeGVLGwlipgdlyeglpleheggkkliyncNAIHVWYITLPLIGILYVtgIAPVSMLYDNfAPILTVAIIFSNLVAIFT 132
                      556677889998888888888888888888888888888888885556666666644333333344444444333344443333333333333 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00018
  Chromate_transp  68 lgvlGaliatlgfflPsfllilllaplleklrk 100
                      +g+  +li+++g f+P f +i+++ ++++++++
       EFC38024.1 353 MGLTWGLICGFGSFIPYFYFIFFFCMIIHRYHR 385
                      478889*********************999865 PP

>> Spore_YhaL  Sporulation protein YhaL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.6      0.98   4.4e+03       9      20 ..     119     130 ..     117     134 .. 0.78
   2 ?   11.7   0.6   3.4e-05      0.15       1      27 [.     267     293 ..     267     296 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.98
  Spore_YhaL   9 iagIlfSgymav 20 
                  ++I+fS   a+
  EFC38024.1 119 TVAIIFSNLVAI 130
                 689****98877 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 3.4e-05
  Spore_YhaL   1 iPwWvYlviagIlfSgymavktakeEr 27 
                 +PwW  l+i  +lf +y +  ta+  r
  EFC38024.1 267 MPWWYNLCIFILLFVAYYFWDTAQSQR 293
                 6******************99998776 PP

>> DUF1516  Protein of unknown function (DUF1516)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.3      0.21   9.4e+02      50     103 ..     108     159 ..      79     164 .. 0.62
   2 ?   10.5   1.9   0.00012      0.55       6     105 ..     176     281 ..     173     283 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.21
     DUF1516  50 vllirtfknspllyilKvllgllvIglmEmalarkkkkksssgllilfivvlvl 103
                  +l+ +f   p+l++  ++  l+ I+    ++a  ++++ s  +l+ f++ +vl
  EFC38024.1 108 SMLYDNF--APILTVAIIFSNLVAIFTYFYTIATGNEHRLSGSFLYDFFMGAVL 159
                 3344443..455555555566777777777777777777777777777766665 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00012
     DUF1516   6 lsWvlliilfivalllysk..gkskaakilhmilRlfyllilvtglvllirtfk....nspllyilKvllgllvIglmEmalarkkkkksssgllilfi 98 
                 +sWvll++l++ a   + +  g   + +i+++++  +y+  ++ g   + ++ +    ++ +l+i   l+g+  ++ +  +++ kk ++ +  +++ + 
  EFC38024.1 176 ISWVLLFLLTLSAAAKQYEelGYITTPMIFMLTAHTIYVNAIMKGEECVPSSWDifyeKWGWLLIYWNLAGVPFVYCFSSIYIYKKGEEINMPWWYNLC 274
                 79******999988877666888899999999*************999888877788899************************999999999999999 PP

     DUF1516  99 vvlvlvi 105
                 ++++l +
  EFC38024.1 275 IFILLFV 281
                 9888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (414 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2465.91
//
Query:       EFC38025.1  [L=1081]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.3e-43  147.4   1.5    4.3e-43  147.4   1.5    2.1  3  HSP70        Hsp70 protein
    2.4e-05   23.7   0.0      0.015   14.6   0.0    3.0  3  StbA         StbA protein
    6.1e-05   22.0   0.0      0.053   12.3   0.0    3.2  3  MreB_Mbl     MreB/Mbl protein
    0.00018   21.3   1.4    0.00064   19.5   0.0    2.6  3  DUF3695      Protein of unknown function (DUF3695)
     0.0056   17.0   0.2       0.27   11.5   0.0    3.4  3  DUF1722      Protein of unknown function (DUF1722)
  ------ inclusion threshold ------
      0.012   14.8   0.3      0.022   14.0   0.3    1.4  1  RdgC         Putative exonuclease, RdgC
      0.026   14.7   0.3      0.026   14.7   0.3    3.0  2  Spore_GerAC  Spore germination B3/ GerAC like, C-terminal
      0.044   13.9   0.1      0.044   13.9   0.1    2.6  3  ApoLp-III    Apolipophorin-III precursor (apoLp-III)


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -6.8   5.5         8   1.8e+04     496     597 ..       6     111 ..       4     113 .. 0.62
   2 ?   -3.5   0.0      0.94   2.1e+03       1      33 [.     140     171 ..     140     173 .. 0.70
   3 !  147.4   1.5   1.9e-46   4.3e-43       2     521 ..     481    1021 ..     480    1078 .. 0.71

  Alignments for each domain:
  == domain 1  score: -6.8 bits;  conditional E-value: 8
                 EECCSSSBHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..GGGSTHHHH..HHHHHHHHHHHCHTTSSCHHHHHHHHHHHHHHH CS
       HSP70 496 ieaseglseeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleee..aekvseaek..ekvesaieeLkeeleeeekeeieakteelkkvv 590
                 i+ s +  +  i+k++  +++s+++d++  +  + + + +++ +    ++ +e  +e v ++e   +  +++  +++e  eee++ ++ +  e+l+  v
  EFC38025.1   6 IKRSATTFKRSIKKLIITSQHSTDDDSAFDDYKQCRTQQTNVKDLKIVHMRNEimGEWVMNDESdcKIKTEKRMSIEEPKEEENHINYCKMNENLEGDV 104
                 666667777888888888888887777766665555555554443333333334444444444432555555666777777777888888999999888 PP

                 HHHHHHH CS
       HSP70 591 ekiaekl 597
                 + i+e++
  EFC38025.1 105 QVIVENY 111
                 8888765 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 0.94
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSE CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrtt 33 
                 +iGiD Gt +s  +  + g+   i++ +++r+t
  EFC38025.1 140 IIGIDCGTFYSQASYHNIGSS-KINDLYSTRIT 171
                 69*********8765554444.45666666666 PP

  == domain 3  score: 147.4 bits;  conditional E-value: 1.9e-46
                  EEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXTT.....SEEETHHHHHCTTTTGGGEEEXGGGTTTXBTTSH..HHHHHHTTXSSEEEE CS
       HSP70    2 iGiDLGttnsvvavmeggkievianeegnrttPsvvaFtkk.....erlvGeaAkrqavtnpkntvfsvKrliGrkfsdp..evqkeikelpykvvk 91  
                  iGiDLGt +++v+ +++ + +    + +     svv  +       +  vGe    + v       +++Kr+iG++ +++  ++q++ k+l yk+v+
  EFC38025.1  481 IGIDLGTSTTIVSYIDEFGYTKYISQGSCNFQNSVVNVSCIngesfQTGVGELEDVNGV----LYATETKRIIGKRKDNQvaVIQENEKKLDYKIVA 573 
                  89999999999998877554444444444555566554432110013444443333333....333578*****98877522689***********9 PP

                  ETTSBEEEEEEETTE.....EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSS CS
       HSP70   92 kengkavveveaage.....kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkd 183 
                  + +++  +++++  e     + +pe ++     k+ e++  + +++   avitvPa f   q++at +A++   ++vl+++ ep Aaa  Y   kkd
  EFC38025.1  574 N-QENQLATCRFVFEngkflDISPELVAQ----KILENVTVFRKDQEIPAVITVPAEFGVFQKNATLEAARKSNIKVLKLLPEPSAAAYYY--FKKD 663 
                  8.445555555554412255555555555....5556667777777789**************************************8766..5555 PP

                  ...SCEEEEEEEEXSSXEEEEEEEEETT.....EEEEEEEEEETTXSHHHHHHHHHHHHHHHHH.HHHSX.........XGGG.SHHHHHHHHHHHH CS
       HSP70  184 ...kernvlvyDlGggtfdvSilelekG.....vfevkaTagDthlGGedfDealvehlveefk.kkegi.........dlsk.dkkalqrlkeaae 261 
                      e n lv+D+Gggt d+S++++ k       f vk   gD++lGG d+D+ + +  ++ +    +++         +l++ +k++ ++l+ +a 
  EFC38025.1  664 pqrGEGNYLVFDFGGGTLDISLIQVCKNhdsqlEFIVKWVEGDSTLGGVDVDNLVFQNYIKPVWfGASSMtleeksltsQLNNlKKEVKHKLSAKAR 760 
                  567999*****************99644333335779****************99875555432022222000000111222212344456666777 PP

                  HHHHHTTTSSCSEEEEEEEEEETTTEEEEEEEEHHHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHT.TCHHBSS CS
       HSP70  262 kaKkeLSsskqteinleietvdedgkdlseklsRakfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelf.gkepskt 357 
                   +K +L s+ + +++   + + e++  l ++++ ++f++ +e+ +++ ++ + + +k+ ++   +i+ev++vGGs+ iP v++ v++ + g   ++ 
  EFC38025.1  761 ILKETLCST-RRNVEYFSIEIPENDLSLIISVNYEQFKRDCEEAFQKRVQTLISKFKELGC---DINEVLMVGGSSLIPFVKDWVQDELpGVTITRP 853 
                  777777774.344443334444557888889999999999999999999999888888775...899******************975516999999 PP

                  SHTT..THHHHHHHHHHHHHCTCGCSHCCEEEEBESS-EEE.EETTTEEEEEESTTCBSSEEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEE CS
       HSP70  358 vnpD..eavaiGAAvqagvlsgeeevkdllllDvtpLslgi.etlggvmtkliernttiptkksqvfstaadnqtaveievlqgerelvkdnkllgs 451 
                   n D   +v++GAA  a+ l      + + ++   + +++i e++ ++  k+ e+ t +p kk   ++  +d+ +++++   +ge e+ +  +ll +
  EFC38025.1  854 QNSDiiYIVSYGAAYLAHDLYQ---KQAIPITECLSRTIRIkEYQNNSLIKVLEKGTPLPCKKLLAVTNSSDETKEINLTFREGESEISSMLELLTN 947 
                  99994447*********99987...78999****9999**95578889******************************************9999988 PP

                  EEEECESSCSTTCSEEEEEEEEETTSCEEEEEEET...TTCCEEEEEEECCSS.SBH.HHHHHHHHHHHHCHHHH CS
       HSP70  452 feldgippaprGvpqieVtfdidanGiltvsakdk...etgkeeeitieaseg.lse.eeiekmvkdaeesaeed 521 
                   ++ +i  +p+ + +i V+ ++d++G++tv+ +d    +t  +e+ t ++++  ls+ ee  +m ++ +e +e+ 
  EFC38025.1  948 -SIIKIDQKPASNHKICVECRVDQDGVFTVNVHDVvsrSTFFSEKFTFSNNQIsLSQpEENSEMWEKLHELTEKV 1021
                  .7889*************************999873224555688888777766555144456666666555544 PP

>> StbA  StbA protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.55   1.2e+03     222     262 ..     546     571 ..     480     600 .. 0.59
   2 !   14.6   0.0   6.6e-06     0.015     126     199 ..     630     712 ..     627     737 .. 0.75
   3 !    5.2   0.0    0.0047        10     215     284 ..     757     834 ..     740     854 .. 0.67

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.55
        StbA 222 deliknrkdeeyLkrrindedkresvlevinekvkkLkerv 262
                 +++i +rkd+++                vi+e++kkL  ++
  EFC38025.1 546 KRIIGKRKDNQVA---------------VIQENEKKLDYKI 571
                 3455555555543...............4444444443333 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 6.6e-06
        StbA 126 mrevelqggesftikkvkvlPeslPagfealke..ldeleslLiiDlGGttLDvakvr......gklegisk.vkgdskiGvs 199
                 +++ +l+     +ik  k lPe   a++   k+       + L+ D+GG tLD++ ++      ++le i k v gds++G  
  EFC38025.1 630 QKNATLEAARKSNIKVLKLLPEPSAAAYYYFKKdpQRGEGNYLVFDFGGGTLDISLIQvcknhdSQLEFIVKwVEGDSTLGGV 712
                 5677788888889*********88777776665566667789*************9974444446777776656677777755 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0047
        StbA 215 rtssfladeliknrkdeeyLkrrindedkresvlevinek.....vkkLkerviravsefsg....ythvmvvGGGael 284
                   +  l ++l + r++ ey + +i ++d    +++v  e+     +++ ++rv+  +s+f++    ++ v++vGG + +
  EFC38025.1 757 AKARILKETLCSTRRNVEYFSIEIPENDLSL-IISVNYEQfkrdcEEAFQKRVQTLISKFKElgcdINEVLMVGGSSLI 834
                 3445677899999999999998887766544.44443332111126789***********9722225679999886643 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.026        59       4      19 ..     481     497 ..     478     509 .. 0.83
   2 !   12.3   0.0   2.4e-05     0.053      79     164 ..     601     688 ..     572     695 .. 0.86
   3 ?    3.0   0.0     0.016        36     256     297 ..     806     845 ..     749     876 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.026
                 EEEEE-SSEEEE.EETT CS
    MreB_Mbl   4 lgiDLGtantlv.yvkg 19 
                 +giDLGt +t+v y+ +
  EFC38025.1 481 IGIDLGTSTTIVsYIDE 497
                 8**********955554 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.4e-05
                 HHHHHHHHTSS-SS--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHH.TT--TTSSS-E.EEEEE-SS-EEEEEEET CS
    MreB_Mbl  79 kyfikkvkkkkslskprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiG.aglpveepsgn.mvvdiGggttevavisl 164
                 ++++++v+  ++ ++   vi+vP +    +++A  eaa+k   +  +l+ ep aAA      + ++ +gn +v d Gggt ++++i +
  EFC38025.1 601 QKILENVTVFRKDQEIPAVITVPAEFGVFQKNATLEAARKSNIKVLKLLPEPSAAAYYyFKKDPQRGEGNyLVFDFGGGTLDISLIQV 688
                 5566777776666777789*************************************752577788888875789**********9965 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.016
                 HHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHH CS
    MreB_Mbl 256 avkevLektppeLaadivdrgivltGGgallkgldkllseet 297
                 +  ++L +   eL  di    ++++GG++l+  +++++++e+
  EFC38025.1 806 KRVQTLISKFKELGCDIN--EVLMVGGSSLIPFVKDWVQDEL 845
                 344555566679999995..5999*************99987 PP

>> DUF3695  Protein of unknown function (DUF3695)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   2.9e-07   0.00064       8      67 ..     750     812 ..     743     815 .. 0.79
   2 ?   -2.0   0.0       1.5   3.4e+03      56      92 ..     971    1007 ..     969    1012 .. 0.80
   3 ?   -2.6   0.1       2.2     5e+03       3      29 ..    1040    1066 ..    1038    1069 .. 0.77

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 2.9e-07
     DUF3695   8 klaqqlepweRLfstqtlsSvRrdarffdpeiPkDsLDfrLksrYdh....hrelfkekvevll 67 
                 +++++l++  R+  ++tl S+Rr++ +f+ eiP+ +L + ++ +Y++     +e+f+++v++l+
  EFC38025.1 750 EVKHKLSAKARIL-KETLCSTRRNVEYFSIEIPENDLSLIISVNYEQfkrdCEEAFQKRVQTLI 812
                 5566677777775.58*****************************9732224678888888876 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.5
     DUF3695   56 relfkekvevllqreTiqaksfrvlrntevlrpkked 92  
                  +++f  +v+ ++ r T+ +++f   +n+  l++++e+
  EFC38025.1  971 DGVFTVNVHDVVSRSTFFSEKFTFSNNQISLSQPEEN 1007
                  6788999999999999999999888888888877765 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 2.2
     DUF3695    3 fkkptklaqqlepweRLfstqtlsSvR 29  
                  ++++t+l +++   e L ++ tlsS+ 
  EFC38025.1 1040 HQANTTLRNCETFVETLQEHLTLSSIE 1066
                  567777888888888999999999975 PP

>> DUF1722  Protein of unknown function (DUF1722)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   0.0   0.00012      0.27      42      78 ..     201     237 ..     178     239 .. 0.89
   2 ?   -1.8   0.0       1.6   3.6e+03      60      90 ..     794     824 ..     790     828 .. 0.82
   3 ?    0.6   0.0      0.29   6.4e+02      73     105 ..     923     955 ..     913     962 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00012
     DUF1722  42 lskpatrkkhinvlqhilgyfkkklsaeekqelleli 78 
                 +s+ ++rk + n + h++g f+k+++++ +++++++i
  EFC38025.1 201 FSNIPERKLNSNLIYHLIGAFSKQIDEDSNKKFITAI 237
                 56779999***********************999876 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.6
     DUF1722  60 gyfkkklsaeekqelleliekYregkvplsv 90 
                 ++fk++++++ ++++++li k++e  +++++
  EFC38025.1 794 EQFKRDCEEAFQKRVQTLISKFKELGCDINE 824
                 6899999999999999999999986666655 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.29
     DUF1722  73 elleliekYregkvplsvpltlLkhyarkydne 105
                 e  e+  ++reg+ ++s++l+lL + ++k d++
  EFC38025.1 923 ETKEINLTFREGESEISSMLELLTNSIIKIDQK 955
                 556667789***************999999876 PP

>> RdgC  Putative exonuclease, RdgC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.3   9.7e-06     0.022     117     211 ..       2      97 ..       1     117 [. 0.89

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 9.7e-06
        RdgC 117 AFsksrktaawidtengllvvdaaSakkaeevlslLrksl.gslpvkplqteqspeaamteWlasgeapagftldeeceLksaeeekavvrckrqd 211
                 AF+k ++ a  ++ + + l++ ++ ++  + +++  +++  ++ +vk l++ +  +++m eW++++e + ++++++ + +++++ee+  + + + +
  EFC38025.1   2 AFQKIKRSATTFKRSIKKLIITSQHSTDDDSAFDDYKQCRtQQTNVKDLKIVHMRNEIMGEWVMNDESDCKIKTEKRMSIEEPKEEENHINYCKMN 97 
                 999999999999999999999999999999999999999736779******************************************999987654 PP

>> Spore_GerAC  Spore germination B3/ GerAC like, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.8      0.85   1.9e+03      32      57 ..     101     125 ..      39     170 .. 0.59
   2 ?   14.7   0.3   1.2e-05     0.026      46     122 ..     723     823 ..     692     826 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.85
                  --EEEEE.ETTEEEE.EEEEEEE.EE CS
  Spore_GerAC  32 sgvitiplpkgkdekvsveisssksk 57 
                   g +++ +++ +++  s+e++s+   
   EFC38025.1 101 EGDVQVIVENYETQ-TSIEKNSNENP 125
                  12222222222222.23333333333 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.2e-05
                  E........EEEEEEE.EEEEEEE-SSSEEEEEEEEEEEEEE................-...----.-----HHHHHHHHHHHHHHHHHHHHHHHHTT CS
  Spore_GerAC  46 k.......vsveissskskikvkiengkpsfdikiklegdie................e...skknlleeeelkelekalekeiekeieealkklqey 117
                           s++ ++++  ++ +++n k +++ k++++++i                 e   ++ +l+ + ++++ ++ +e++++k+++ ++ k++e+
   EFC38025.1 723 IkpvwfgaSSMTLEEKS--LTSQLNNLKKEVKHKLSAKARILketlcstrrnveyfsiEipeNDLSLIISVNYEQFKRDCEEAFQKRVQTLISKFKEL 818
                  35555555555555555..788888888888888888888776666665555544444144466777777778999********************** PP

                  ----S CS
  Spore_GerAC 118 ksDil 122
                  ++Di 
   EFC38025.1 819 GCDIN 823
                  ***96 PP

>> ApoLp-III  Apolipophorin-III precursor (apoLp-III)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1     2e-05     0.044      32     118 ..     738     830 ..     735     844 .. 0.87
   2 ?   -3.3   0.0         4   8.9e+03      76      92 ..    1005    1021 ..    1000    1022 .. 0.71
   3 ?   -2.5   0.1       2.1   4.8e+03      30      50 ..    1041    1061 ..    1033    1073 .. 0.57

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2e-05
   ApoLp-III  32 enlvdqlkqvikslqeelkkksdeleealkevkkkieetadklse......enPevkkkaqelqekvQsgvqslvkesqklaeslkensqeak 118
                 ++l +ql+++ k+++ +l  k  +l+e+l  ++ ++e    ++ e       + + ++   + +e +Q++vq+l++  ++l+ +++e      
  EFC38025.1 738 KSLTSQLNNLKKEVKHKLSAKARILKETLCSTRRNVEYFSIEIPEndlsliISVNYEQFKRDCEEAFQKRVQTLISKFKELGCDINEVLMVGG 830
                 57889********************************999999997777777889999999*********************99998665555 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 4
   ApoLp-III   76 eenPevkkkaqelqekv 92  
                  een+e+ +k+ el ekv
  EFC38025.1 1005 EENSEMWEKLHELTEKV 1021
                  36777888888777775 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.1
   ApoLp-III   30 nsenlvdqlkqvikslqeelk 50  
                  ++++ +++ +++ ++lqe l+
  EFC38025.1 1041 QANTTLRNCETFVETLQEHLT 1061
                  444455555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1081 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1270  (0.070835); expected 358.6 (0.02)
Passed bias filter:                      565  (0.0315132); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.82u 0.30s 00:00:01.11 Elapsed: 00:00:00.47
# Mc/sec: 6919.07
//
Query:       EFC38026.1  [L=466]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.076   12.1   0.0        3.9    6.5   0.0    3.1  3  Fibrillarin      Fibrillarin
      0.097   12.8  38.1       0.32   11.2   8.3    3.6  3  FYVE             FYVE zinc finger
       0.16   12.8  41.3       0.42   11.5   7.9    3.9  3  Tnp_zf-ribbon_2  DDE_Tnp_1-like zinc-ribbon
       0.49    9.3   2.5       0.77    8.7   2.5    1.2  1  Amidase          Amidase
        1.4    9.1  38.4        2.2    8.5   7.4    4.0  3  zf-AN1           AN1-like Zinc finger


Domain annotation for each model (and alignments):
>> Fibrillarin  Fibrillarin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0    0.0011       3.9      64      95 ..      24      55 ..      18      69 .. 0.82
   2 ?   -0.1   0.0      0.12   4.2e+02      75     103 ..      92     120 ..      85     128 .. 0.81
   3 ?    0.7   0.0     0.067   2.4e+02      74      93 ..     149     168 ..     131     173 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0011
                 S--S--TTSEEEEESTTTSHHHHHHHHHHTTT CS
  Fibrillarin 64 kelpikkgskvLYlGaasGttvsHvsDivgee 95
                 k+++++  ++ L l  +s +t sHvsD+v+ +
   EFC38026.1 24 KQCKMNYCDNHLNLHNTSNKTKSHVSDLVELS 55
                 66677777788999999************965 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.12
                  EEESTTTSHHHHHHHHHHTTTSEEEEEES CS
  Fibrillarin  75 LYlGaasGttvsHvsDivgeegvvyavef 103
                  L l  +s +t sH s +v  e+ v a   
   EFC38026.1  92 LNLHNTSNKTKSHASSVVPIESQVSAAKN 120
                  556778999**********9999987665 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.067
                  EEEESTTTSHHHHHHHHHHT CS
  Fibrillarin  74 vLYlGaasGttvsHvsDivg 93 
                   L l  +s +t sHv D+ +
   EFC38026.1 149 HLKLHNSSNKTKSHVNDVSE 168
                  57788999*********976 PP

>> FYVE  FYVE zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   8.3   8.9e-05      0.32       9      65 ..       3      69 ..       1      72 [. 0.73
   2 ?    7.0  12.8    0.0018       6.4       7      65 ..      58     127 ..      56     130 .. 0.76
   3 ?    9.6  10.1   0.00027      0.97       7      51 ..     116     161 ..     112     282 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.9e-05
                -SB-TTT--B-.-SSS--EE-TTT--EE-STTS.........-EEE.EEGGGTEEEEEEE-HHHHHH CS
        FYVE  9 vkkCeiCakkF.sllrrrhhCrlCGkvvCekCs.........sklvallekeaeeksvrvCkeClae 65
                v +C++C k   +++   h C+ C   +C+++          +++v++l + ++ + +r C++Cl++
  EFC38026.1  3 VVNCDKCLKDEnETVPATHNCKQCKMNYCDNHLnlhntsnktKSHVSDLVELSAASTIRNCDKCLKD 69
                679****8877578899************77773333333334444444777788888******986 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0018
                 .--SB-TTT--B-.-SSS--EE-TTT--EE-STTS-EEE.EE..........GGGTEEEEEEE-HHHHHH CS
        FYVE   7 sevkkCeiCakkF.sllrrrhhCrlCGkvvCekCssklvall..........ekeaeeksvrvCkeClae 65 
                 s++++C++C k   +++   h C  C  ++Ce++ + + ++           + e++++  + C++Cl +
  EFC38026.1  58 STIRNCDKCLKDEdETIPATHSCPSCNMCFCENHLNLHNTSNktkshassvvPIESQVSAAKNCDKCLTD 127
                 57899****998878889*************888854444443333444444788888888******875 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00027
                 .--SB-TTT--B-.-SSS--EE-TTT--EE-STTS-EEE.EEGGGT CS
        FYVE   7 sevkkCeiCakkF.sllrrrhhCrlCGkvvCekCssklvallekea 51 
                 s++k+C++C +   + +   hhC+ C   +Ce++ + + ++ ++++
  EFC38026.1 116 SAAKNCDKCLTDDeEKVLATHHCKQCNAHMCENHLKLHNSSNKTKS 161
                 6799*****999877889*************999876665553333 PP

>> Tnp_zf-ribbon_2  DDE_Tnp_1-like zinc-ribbon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   8.7    0.0038        14       2      30 ..       5      34 ..       4      34 .. 0.90
   2 ?    6.2   8.8    0.0053        19       1      30 [.      61      91 ..      61      91 .. 0.95
   3 ?   11.5   7.9   0.00012      0.42       1      30 [.     119     149 ..     119     149 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0038
  Tnp_zf-ribbon_2  2 RCkvClkkkikke.TriiCqeCdvplCrnh 30
                     +C  Clk+ +++  +++ C++C    C+nh
       EFC38026.1  5 NCDKCLKDENETVpATHNCKQCKMNYCDNH 34
                     79*****7777777***************8 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0053
  Tnp_zf-ribbon_2  1 kRCkvClkkkikke.TriiCqeCdvplCrnh 30
                     ++C  Clk+ +++  ++++C +C+   C nh
       EFC38026.1 61 RNCDKCLKDEDETIpATHSCPSCNMCFCENH 91
                     69********99988**************98 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 0.00012
  Tnp_zf-ribbon_2   1 kRCkvClkkkikke.TriiCqeCdvplCrnh 30 
                      k+C  Cl +  +k  +++ C++C+ + C nh
       EFC38026.1 119 KNCDKCLTDDEEKVlATHHCKQCNAHMCENH 149
                      79******66666568**************8 PP

>> Amidase  Amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   2.5   0.00021      0.77      98     142 ..     142     186 ..     138     194 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00021
                 EE--SGGG-SSSSTT-TT---BBTTCTCCB--SSSHHHHHHHHTT CS
     Amidase  98 kTnmdefamgsstensvfgptrNPwdksrtpGGSSGGsAAavAag 142
                  ++m+e  + +  +++ +   +N +++  ++G SSGGs++ vAa 
  EFC38026.1 142 NAHMCENHLKLHNSSNKTKSHVNDVSELTSAGSSSGGSGSSVAAS 186
                 56777777788888888888889999999**************96 PP

>> zf-AN1  AN1-like Zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   7.4   0.00061       2.2       5      28 ..       8      35 ..       5      39 .. 0.76
   2 ?    5.6   7.3    0.0048        17       5      28 ..      65      92 ..      59      96 .. 0.75
   3 ?    5.9   7.8     0.004        14       6      28 ..     124     150 ..     118     154 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00061
      zf-AN1  5 sCkkkd..flp..fkCryCgkvFClkHr 28
                +C k +  ++p   +C++C+ ++C +H 
  EFC38026.1  8 KCLKDEneTVPatHNCKQCKMNYCDNHL 35
                576666545667899************6 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0048
      zf-AN1  5 sCkkkd..flp..fkCryCgkvFClkHr 28
                +C k +  ++p    C++C+  FC++H 
  EFC38026.1 65 KCLKDEdeTIPatHSCPSCNMCFCENHL 92
                565555555557799************6 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.004
      zf-AN1   6 Ckkkd....flp.fkCryCgkvFClkHr 28 
                 C + d    + +  +C++C+ + C++H 
  EFC38026.1 124 CLTDDeekvL-AtHHCKQCNAHMCENHL 150
                 5555544423.359*************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (466 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1162  (0.0648112); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2691.82
//
Query:       EFC38027.1  [L=551]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.2e-17   61.9   0.0    9.1e-17   61.3   0.0    1.3  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
  ------ inclusion threshold ------
      0.048   13.6  11.5        3.7    7.6   0.6    4.1  3  zf-CCCH        Zinc finger C-x8-C-x5-C-x3-H type (and similar


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.3   0.0     1e-20   9.1e-17       2     233 .]     297     542 ..     296     542 .. 0.85

  Alignments for each domain:
  == domain 1  score: 61.3 bits;  conditional E-value: 1e-20
                    EEEESTG.............CHHHHTHHHHHHHHHHHHHHCTTSEEEEEEEBSCTCHHHHHHHHHTTCEEEEECCHECSSSTTSSEEEEEECSTEE CS
                    xxxxxxx.............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos   2 twNvngq.............aspalgssrrsdrladlltaydaDvlgLQEvdddelsriplllalggflgasstsptgggggggnggavlsrfplt 84 
                    ++N++ q             +++ l++  r+  + ++l++ + D++gLQE+d++++s i   l + gf  ++s    + ++ + +g+ +++r + +
     EFC38027.1 297 SYNILAQcyislsrysnitnQKY-LDWEIRKYKIFSVLKERRFDIIGLQEIDNQHASQIQFFLEQEGFSVYHS----YKNYPKKDGLILAIRNTKF 387
                    89999999999999888886666.8888888888888888899****************87776644444444....5799**************8 PP

                    EEEEEEEEETSSSSGCEEEEEEEEEEEEEEE............................CCCHHGHHHHHHHHHHHHHHHHHHHHHTTSEEEEEEE CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  85 slfrrtfiefndlvaalrreplaakleqlni............................ashrdhdlvrdlqllalllqvealnadrgapvivaGD 152
                    ++f                 + ++k +   +                             + ++   +r+ q    l q+    ++++ ++i++GD
     EFC38027.1 388 EIF-----------------NKGEKTL---VkeypevfqyviardrvkgrffciinchlTFQPRDTGPREKQVNEILNQIGKIADPQKTSIIWFGD 463
                    882.................2222222...123356666677888888888999****************************************** PP

                    -SSSTSGGGBSCGHHHHHHCTTTHHSSCESCETTTTTTTTTTTEB-BEEEEEECHHHCCEEEEEEECCHHEEC.TSSCSSSB CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxx RF
  Exo_endo_phos 153 fNarpsdddsrvlrtrglalapapvglyllgggptptyvtraggsrlDrilaspalalfrsgvlppplalvrr.ealtlSDH 233
                    fN+ p++ + +++++    + +     + + ++ ++ + t + +s +D+i+ sp+l + +sg  ++ ++ +   +++ +SDH
     EFC38027.1 464 FNTSPHEKPIQLIEACESIPLQ---KSHDTVQEFWTCCGTTGRNSIVDYIWHSPSLQVKDSGPCLEFVPKSSIpDEDHGSDH 542
                    ************9999999999...7*********************************99999999888888********9 PP

>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.3    0.0019        17      13      22 ..      28      37 ..      23      37 .. 0.82
   2 ?    7.6   0.6   0.00041       3.7       9      22 ..     102     115 ..     100     117 .. 0.81
   3 ?    5.6   0.5    0.0017        15      14      21 ..     133     140 ..     127     140 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0019
                S--TTGGG-S CS
     zf-CCCH 13 GyCkyGdrCk 22
                ++C++G  C+
  EFC38027.1 28 HTCPFGKDCS 37
                79*******6 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00041
                 HHHHS--TTGGG-S CS
     zf-CCCH   9 fmrtGyCkyGdrCk 22 
                 f+ ++ CkyG +Ck
  EFC38027.1 102 FQFYHPCKYGLNCK 115
                 666788*******9 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0017
                 --TTGGG- CS
     zf-CCCH  14 yCkyGdrC 21 
                  CkyG++C
  EFC38027.1 133 PCKYGEKC 140
                 7******* PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (551 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1319  (0.073568); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.26s 00:00:00.87 Elapsed: 00:00:00.43
# Mc/sec: 3866.15
//
Query:       EFC38028.1  [L=1384]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-81  274.8   0.1    4.5e-81  273.3   0.0    1.8  2  RdRP      RNA dependent RNA polymerase
    1.7e-34  117.4  10.5    1.7e-07   31.7   0.1    7.9  8  Sel1      Sel1 repeat
    1.9e-06   28.1   2.0        0.1   12.9   0.2    4.0  3  TPR_12    Tetratricopeptide repeat
    5.1e-05   23.1  20.4      0.013   15.6   0.1    5.5  6  TPR_2     Tetratricopeptide repeat
    0.00023   21.3   3.5     0.0059   16.9   0.1    4.1  3  TPR_17    Tetratricopeptide repeat
     0.0009   19.8   0.4        0.6   10.8   0.1    3.0  2  TPR_16    Tetratricopeptide repeat
     0.0014   18.7  17.0     0.0024   17.9   1.5    5.4  5  TPR_8     Tetratricopeptide repeat
     0.0015   18.4   4.8        1.2    9.4   0.0    4.0  2  TPR_7     Tetratricopeptide repeat
      0.004   16.9  19.6     0.0055   16.5   2.9    4.9  5  TPR_1     Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.03   15.1   0.6         17    6.5   0.4    3.4  2  TPR_14    Tetratricopeptide repeat
      0.047   13.6   3.0       0.38   10.7   0.2    3.4  3  TPR_10    Tetratricopeptide repeat
        0.1   12.3   0.1        0.1   12.3   0.1    4.7  5  TPR_11    TPR repeat
       0.12   12.8   2.4       0.42   11.1   2.4    1.9  1  YlbE      YlbE-like protein
       0.32   11.1  13.4        1.2    9.2   0.2    6.4  6  MIT       MIT (microtubule interacting and transport) domain
       0.75   10.3   3.3         43    4.7   0.0    3.5  3  TPR_19    Tetratricopeptide repeat
          5    7.5   8.6         19    5.6   0.8    4.4  3  PRD       PRD domain
        6.9    7.5  10.0       0.42   11.3   1.7    3.5  2  TPR_6     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> RdRP  RNA dependent RNA polymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  273.3   0.0   4.3e-84   4.5e-81      61     585 ..     282     806 ..     231     807 .. 0.78
   2 ?   -3.5   0.0       2.8   2.9e+03     485     537 ..    1034    1085 ..    1009    1092 .. 0.69

  Alignments for each domain:
  == domain 1  score: 273.3 bits;  conditional E-value: 4.3e-84
        RdRP  61 kegiviagrkfeflafsdsqlrehsvwffapf....eeegerisaeeirkwlgdfe.nisq..svaKyaaRlglalSttrp..tvvkvereqiiieeid 150
                 +e+++iag +f+ l+ ++s++ + + ++++p     ++ ++++s++++  w ++ + n +   +  K+ + l lal +t    t + v++  +    i+
  EFC38028.1 282 EEPLHIAGFTFQKLCQNTSGMHSYRFIYMCPDlsklPN-NSSLSIHDVKTWAIPDTlNRDLyfENNKLKQSLRLALFNTPVipT-IGVSEYTV----IN 374
                 678**************************877776433.3359*********99865443234677777777777777776324.45443333....33 PP

        RdRP 151 DvkneekdiylftDGvGliSrelarkiakklglkk...........................aeelPsafQiRigGaKGvlavdkrlkp...ekielrp 219
                        d  lftDG+G+iS ela k+ + ++ +k                           +e+lP+a+QiR++GaKG++ ++++ ++   +++ lr+
  EFC38028.1 375 -------DEGLFTDGCGFISLELAMKVYEIVRKSKnllkyqskqsmdedgiyeendgveflvNEYLPCAYQIRFRGAKGMVYIHPNAEKvygHHLVLRK 466
                 .......3479*****************98888888899999********************99********************999333444599*** PP

        RdRP 220 SqiKfkseed.dsekrtleivkvsskpkpayLnrqlikiLedlgv...peevflellkealeelrealkdagaaaellkkagdpskleellaelldsgf 314
                 S++K++++++ d+  ++l iv +ss+   a++n  ++ iLe +     + ++f+ l ++a + +++ +k++ +          +s++++++ ++++ g 
  EFC38028.1 467 SMMKIEHPNTdDDIINNLCIVGYSSPCDFARINSTIMHILEGCEDetkQGKIFEILNQKACKHIENLMKNYIS----------ESDIDKVFDQYVKQGD 555
                 *****99988766789*************************99984445567999999***********9966..........9************987 PP

        RdRP 315 dpsel.dpflrsllkalvkeslrklkekarIpvpksatllgvaDetgvLkegevfvqlse.aldqedeksktkllkgdvlVtRnPalhpgDiqvvkavd 411
                   s +   +l+s+  a+++   r++  ++rIp+  s+ l+g+aD++gvLkeg++f+q+s+ + d     +k+++++++v+Vt+ P+lh gD ++++av+
  EFC38028.1 556 YASLNvLSILKSKKLAFLTGPYRNQILSLRIPCYSSRRLYGIADPFGVLKEGQIFIQVSSlN-DP----KKKNVIENTVIVTKEPCLHRGDLRKLEAVN 649
                 76645679****************************************************54.33....346799999********************9 PP

        RdRP 412 vpelrhlkdviVFstkGdrslaselsGGDlDGDkywViwdpe.lefapakpsneepadyeeakpkeldrevtvediadffveymksdvlGlisnahlai 509
                 +pel+ l dviVF+tkG+r++ ++++G+DlDGD+y+ +wd+e +e      +++ p +++ +         + +++++f  +   +d +G+   +   +
  EFC38028.1 650 IPELNFLYDVIVFPTKGSRPITNMIAGSDLDGDQYFACWDNElVE---SLVEFD-PGSFD-D---------DYNETRSFDPDI-FKDLIGIRHLFADFY 733
                 9*****************************************554...335554.66666.3.........233456666555.566677666666655 PP

        RdRP 510 adq.eegiddpkclkLaelhskaVDypKtGipvdk...keiprelkkpke...kPdfkekekkekakkpyykskkilgkLyre 585
                  +q +++   +++ +L +l   a+D+pK+G+   +   ++   el   ++   +P++++++     + p  +s +++gkLy++
  EFC38028.1 734 GNQwSRK-YWNNMERLCTLINRAIDAPKKGNYSVAvnaQD--LELL--EKfpgFPHYHKNK-----HGPLRRSVSLVGKLYDS 806
                 5554333.457899****************8766422222..1222..2223599998433.....358899*********97 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.8
        RdRP  485 diadffveymksdvlGlisnahlaiadqeegiddpkclkLaelhskaVDypKt 537 
                  ++ ++f ++ +s+ +  i+    ++ d ++gi++++ l   +l+ ka+D +K+
  EFC38028.1 1034 ETFELFKKVYDSNYIPAINYVASMLEDGDNGISSNELL-AFKLYQKALDLSKQ 1085
                  44555556667777777766666777767777776665.56999999999998 PP

>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       6.8   7.1e+03      15      33 ..    1003    1024 ..     996    1025 .. 0.66
   2 !   12.0   0.0   0.00025      0.26       3      36 ..    1050    1082 ..    1048    1084 .. 0.86
   3 ?   -0.2   0.0       1.8   1.9e+03      21      34 ..    1147    1160 ..    1138    1162 .. 0.87
   4 !   25.4   0.0   1.6e-08   1.7e-05       1      35 [.    1166    1198 ..    1166    1201 .. 0.92
   5 !   19.4   2.0   1.2e-06    0.0012       1      38 []    1204    1235 ..    1204    1235 .. 0.88
   6 !   20.6   0.0     5e-07   0.00053       2      38 .]    1237    1273 ..    1236    1273 .. 0.83
   7 !   31.7   0.1   1.6e-10   1.7e-07       2      37 ..    1275    1310 ..    1274    1311 .. 0.88
   8 ?    5.3   0.0     0.033        35      19      38 .]    1323    1342 ..    1315    1342 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 6.8
        Sel1   15 nGl..g.vpkDpekAiewyekA 33  
                  + +  + ++   +k+++++++A
  EFC38028.1 1003 ASQldMiLEVSNDKGEKLFQQA 1024
                  55553334456899******99 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 0.00025
        Sel1    3 AmyrLGmfylylnGl.gvpkDpekAiewyekAAeq 36  
                  A + ++   ++++G+ g+  ++ +A+++y+kA ++
  EFC38028.1 1050 AINYVA--SMLEDGDnGISSNELLAFKLYQKALDL 1082
                  566788..677****88***************887 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 1.8
        Sel1   21 kDpekAiewyekAA 34  
                   ++++A+e+y  A 
  EFC38028.1 1147 GNYQEAHELYLEAS 1160
                  49********9996 PP

  == domain 4  score: 25.4 bits;  conditional E-value: 1.6e-08
        Sel1    1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAe 35  
                  ++++y+ G  ++y+ G+gv  D+++Ai wy kA e
  EFC38028.1 1166 SDSQYDIG--EMYELGDGVLLDKHEAIIWYLKAVE 1198
                  689*****..999********************77 PP

  == domain 5  score: 19.4 bits;  conditional E-value: 1.2e-06
        Sel1    1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38  
                  +eA++rLG  y  l+   + kD +kA  +y+kAAe+G+
  EFC38028.1 1204 SEALFRLG--Y--LYK--ELKDNQKAWDYYQKAAELGN 1235
                  79******..8..555..479***************97 PP

  == domain 6  score: 20.6 bits;  conditional E-value: 5e-07
        Sel1    2 eAmyrLGmfylylnGlgvpk..DpekAiewyekAAeqGd 38  
                  eA+y ++++y  ++ l + +  ++++A+ewy k+A+qG+
  EFC38028.1 1237 EAQYEVACIY--HHTLNIIQtpNYSLAFEWYCKSANQGN 1273
                  8******555..7777644447****************7 PP

  == domain 7  score: 31.7 bits;  conditional E-value: 1.6e-10
        Sel1    2 eAmyrLGmfylylnGlg..vpkDpekAiewyekAAeqG 37  
                   A+y LGm+y  ++Gl+  vpk++++A+ w+ kAA+q 
  EFC38028.1 1275 NAQYSLGMIY--MYGLDkvVPKNIKLAHSWLLKAAQQQ 1310
                  69*****888..9999446****************995 PP

  == domain 8  score: 5.3 bits;  conditional E-value: 0.033
        Sel1   19 vpkDpekAiewyekAAeqGd 38  
                   ++D+ ++  w+ kAA++G+
  EFC38028.1 1323 CETDVTQGTLWLLKAAKNGN 1342
                  7899999999********97 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.51   5.3e+02      22      36 ..    1072    1086 ..    1068    1092 .. 0.78
   2 !   10.4   0.0    0.0006      0.63      45      71 ..    1133    1159 ..    1130    1167 .. 0.76
   3 !   12.9   0.2   9.9e-05       0.1      44      74 ..    1203    1233 ..    1186    1236 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.51
      TPR_12   22 Alellekaleiarrl 36  
                  A++l++kal++ ++ 
  EFC38028.1 1072 AFKLYQKALDLSKQK 1086
                  889999999998554 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.0006
      TPR_12   45 attlrnLgrlyralgryeeAlelleea 71  
                  +++lrn +r+++  g+y+eA+el+ ea
  EFC38028.1 1133 IEALRNVARMFFNKGNYQEAHELYLEA 1159
                  567778888887778888888887776 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 9.9e-05
      TPR_12   44 tattlrnLgrlyralgryeeAlelleealai 74  
                   +++l+ Lg ly +l++ ++A++++++a ++
  EFC38028.1 1203 NSEALFRLGYLYKELKDNQKAWDYYQKAAEL 1233
                  4689************************886 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0         7   7.3e+03      20      33 ..    1017    1030 ..    1015    1031 .. 0.74
   2 ?    0.8   0.2      0.68   7.1e+02      20      32 ..    1072    1084 ..    1071    1086 .. 0.85
   3 !   15.6   0.1   1.2e-05     0.013       2      27 ..    1134    1159 ..    1133    1165 .. 0.94
   4 ?   -0.1   0.0       1.3   1.4e+03      17      29 ..    1186    1198 ..    1183    1202 .. 0.85
   5 !   15.5   2.7   1.3e-05     0.014       2      30 ..    1205    1233 ..    1204    1237 .. 0.94
   6 ?   -2.9   0.2       9.8     1e+04       3      13 ..    1276    1286 ..    1275    1286 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 7
       TPR_2   20 AleafekAleldPn 33  
                   +++f++A+ +  +
  EFC38028.1 1017 GEKLFQQAIHYSKT 1030
                  57899999987766 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.68
       TPR_2   20 AleafekAleldP 32  
                  A ++++kAl l  
  EFC38028.1 1072 AFKLYQKALDLSK 1084
                  7799*****9975 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 1.2e-05
       TPR_2    2 ealynlGlayyklgdyeeAleafekA 27  
                  eal n ++  +++g+y+eA+e++ +A
  EFC38028.1 1134 EALRNVARMFFNKGNYQEAHELYLEA 1159
                  799*********************99 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 1.3
       TPR_2   17 yeeAleafekAle 29  
                    eA+ ++ kA+e
  EFC38028.1 1186 KHEAIIWYLKAVE 1198
                  679********98 PP

  == domain 5  score: 15.5 bits;  conditional E-value: 1.3e-05
       TPR_2    2 ealynlGlayyklgdyeeAleafekAlel 30  
                  eal++lG++y +l+d ++A ++++kA el
  EFC38028.1 1205 EALFRLGYLYKELKDNQKAWDYYQKAAEL 1233
                  89*************************98 PP

  == domain 6  score: -2.9 bits;  conditional E-value: 9.8
       TPR_2    3 alynlGlayyk 13  
                  a y lG++y++
  EFC38028.1 1276 AQYSLGMIYMY 1286
                  6899*****96 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.25   2.6e+02      11      34 .]    1131    1154 ..    1126    1154 .. 0.88
   2 !   16.9   0.1   5.6e-06    0.0059       2      32 ..    1193    1223 ..    1192    1225 .. 0.96
   3 ?   -1.9   0.0       5.5   5.8e+03       9      23 ..    1270    1284 ..    1268    1300 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.25
      TPR_17   11 nnadaynnLAelllknGdlmtArq 34  
                  ++ +a+ n A+ + ++G++++A++
  EFC38028.1 1131 THIEALRNVARMFFNKGNYQEAHE 1154
                  567899999*************86 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 5.6e-06
      TPR_17    2 ylkaleldPnnadaynnLAelllknGdlmtA 32  
                  ylka+e d +n++a++ L++l+++++d ++A
  EFC38028.1 1193 YLKAVESDVKNSEALFRLGYLYKELKDNQKA 1223
                  9**************************9998 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 5.5
      TPR_17    9 dPnnadaynnLAell 23  
                  +  n++a + L+ ++
  EFC38028.1 1270 NQGNSNAQYSLGMIY 1284
                  6789********999 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0     0.021        22      36      60 ..    1135    1159 ..    1132    1177 .. 0.66
   2 !   10.8   0.1   0.00057       0.6      20      66 ..    1190    1236 ..    1187    1238 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.021
      TPR_16   36 AllllgdaalrqgrlaeAaalyraa 60  
                  Al + +++++ +g+++eA +ly++a
  EFC38028.1 1135 ALRNVARMFFNKGNYQEAHELYLEA 1159
                  6666666666666666666666554 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00057
      TPR_16   20 leaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapd 66  
                    ++lk+  s+  + eAl+ lg ++ ++++ ++A ++y++a++ + +
  EFC38028.1 1190 IIWYLKAVESDVKNSEALFRLGYLYKELKDNQKAWDYYQKAAELGNN 1236
                  5578899999999****************************987766 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1       1.5   1.6e+03      20      33 ..    1072    1085 ..    1070    1086 .. 0.87
   2 ?    4.3   0.1     0.055        58       6      27 ..    1138    1159 ..    1133    1161 .. 0.86
   3 ?    3.8   0.0     0.079        84      16      31 ..    1185    1200 ..    1185    1203 .. 0.90
   4 !   17.9   1.5   2.3e-06    0.0024       2      30 ..    1205    1233 ..    1204    1235 .. 0.95
   5 ?   -2.2   0.3       6.8   7.1e+03       3      12 ..    1276    1285 ..    1274    1286 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 1.5
                  HHHHHHHHHHHHHH CS
       TPR_8   20 Akeyyekaleldpd 33  
                  A + y+kal+l+++
  EFC38028.1 1072 AFKLYQKALDLSKQ 1085
                  7789*******986 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.055
                  HHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8    6 nlgsiylklgdyeeAkeyyeka 27  
                  n ++  +++g+y+eA e y +a
  EFC38028.1 1138 NVARMFFNKGNYQEAHELYLEA 1159
                  6688999***********9998 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.079
                  -HHHHHHHHHHHHHHH CS
       TPR_8   16 dyeeAkeyyekaleld 31  
                  d++eA+ +y ka+e d
  EFC38028.1 1185 DKHEAIIWYLKAVESD 1200
                  789**********976 PP

  == domain 4  score: 17.9 bits;  conditional E-value: 2.3e-06
                  CHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8    2 eayynlgsiylklgdyeeAkeyyekalel 30  
                  ea+++lg++y++l+d ++A  yy+ka el
  EFC38028.1 1205 EALFRLGYLYKELKDNQKAWDYYQKAAEL 1233
                  89************************987 PP

  == domain 5  score: -2.2 bits;  conditional E-value: 6.8
                  HHHHHHHHHH CS
       TPR_8    3 ayynlgsiyl 12  
                  a y lg+iy+
  EFC38028.1 1276 AQYSLGMIYM 1285
                  7899*****7 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0    0.0011       1.2       1      29 [.    1135    1161 ..    1135    1175 .. 0.84
   2 !    7.9   1.0    0.0033       3.5       1      28 [.    1206    1233 ..    1206    1241 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0011
       TPR_7    1 aLlnLarlysrlGdyeeAielyeqsLalt 29  
                  aL n ar++++ G+y+eA ely +  a t
  EFC38028.1 1135 ALRNVARMFFNKGNYQEAHELYLE--AST 1161
                  68899*****************99..666 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0033
       TPR_7    1 aLlnLarlysrlGdyeeAielyeqsLal 28  
                  aL++L+ ly +l d ++A ++y+++ +l
  EFC38028.1 1206 ALFRLGYLYKELKDNQKAWDYYQKAAEL 1233
                  799*********************7666 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.64   6.7e+02      20      30 ..    1072    1082 ..    1071    1085 .. 0.83
   2 !    8.9   0.2    0.0013       1.4       2      27 ..    1134    1159 ..    1133    1160 .. 0.92
   3 ?   -3.2   0.0       8.6   9.1e+03      19      29 ..    1188    1198 ..    1185    1200 .. 0.79
   4 !   16.5   2.9   5.2e-06    0.0055       2      30 ..    1205    1233 ..    1204    1234 .. 0.95
   5 ?   -0.9   0.1       1.6   1.7e+03       2      12 ..    1275    1285 ..    1274    1286 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.64
                  HHHHHHHHHHH CS
       TPR_1   20 AleyyekALel 30  
                  A + y+kAL l
  EFC38028.1 1072 AFKLYQKALDL 1082
                  6789*****98 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0013
                  HHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1    2 kalynlGnayfklgkydeAleyyekA 27  
                  +al n + ++f++g+y+eA e y +A
  EFC38028.1 1134 EALRNVARMFFNKGNYQEAHELYLEA 1159
                  789999****************9887 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 8.6
                  HHHHHHHHHHH CS
       TPR_1   19 eAleyyekALe 29  
                  eA+  y kA+e
  EFC38028.1 1188 EAIIWYLKAVE 1198
                  88999999987 PP

  == domain 4  score: 16.5 bits;  conditional E-value: 5.2e-06
                  HHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1    2 kalynlGnayfklgkydeAleyyekALel 30  
                  +al++lG++y +l++ ++A +yy+kA el
  EFC38028.1 1205 EALFRLGYLYKELKDNQKAWDYYQKAAEL 1233
                  89************************987 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 1.6
                  HHHHHHHHHHH CS
       TPR_1    2 kalynlGnayf 12  
                  +a y lG++y+
  EFC38028.1 1275 NAQYSLGMIYM 1285
                  689*******8 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.063        66       2      34 ..    1134    1166 ..    1133    1169 .. 0.85
   2 ?    6.5   0.4     0.016        17       2      34 ..    1205    1237 ..    1204    1243 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.063
      TPR_14    2 eallalaeallalGdpdeAiallrralalaPdd 34  
                  eal+  a+ +++ G+++eA +l+ +a  ++ d+
  EFC38028.1 1134 EALRNVARMFFNKGNYQEAHELYLEASTKFNDS 1166
                  677778999**************9998877665 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.016
      TPR_14    2 eallalaeallalGdpdeAiallrralalaPdd 34  
                  eal +l+ ++ +l d ++A +++++a +l+ ++
  EFC38028.1 1205 EALFRLGYLYKELKDNQKAWDYYQKAAELGNNE 1237
                  7999**********************9987665 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       1.2   1.3e+03      21      36 ..    1072    1087 ..    1072    1092 .. 0.86
   2 ?   10.7   0.2   0.00036      0.38       4      28 ..    1135    1159 ..    1133    1161 .. 0.93
   3 ?   -0.0   0.3      0.83   8.8e+02       8      30 ..    1210    1232 ..    1209    1234 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.2
      TPR_10   21 Aealleealairrrll 36  
                  A +l+++al++ ++ l
  EFC38028.1 1072 AFKLYQKALDLSKQKL 1087
                  789*******999877 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00036
      TPR_10    4 slnNLanalrqrgrydeAealleea 28  
                  +l N a++ ++ g+y+eA +l+ ea
  EFC38028.1 1135 ALRNVARMFFNKGNYQEAHELYLEA 1159
                  899*******************998 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.83
      TPR_10    8 LanalrqrgrydeAealleeala 30  
                  L+ ++ ++++ ++A +++++a +
  EFC38028.1 1210 LGYLYKELKDNQKAWDYYQKAAE 1232
                  999***************99976 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0         7   7.4e+03       2      13 ..     340     351 ..     340     352 .. 0.86
   2 ?   -2.9   0.1       5.6   5.9e+03       2      10 ..     548     556 ..     548     557 .. 0.87
   3 ?    0.4   0.1      0.51   5.4e+02      14      25 ..    1073    1084 ..    1071    1086 .. 0.82
   4 ?    5.8   0.1     0.011        11       2      21 ..    1141    1160 ..    1140    1173 .. 0.91
   5 ?   12.3   0.1   9.7e-05       0.1      12      41 ..    1188    1217 ..    1187    1218 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 7
      TPR_11   2 dayyeqGkyeeA 13 
                 d+y+e +k++++
  EFC38028.1 340 DLYFENNKLKQS 351
                 78******9987 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 5.6
      TPR_11   2 dayyeqGky 10 
                 d y++qG+y
  EFC38028.1 548 DQYVKQGDY 556
                 68******9 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.51
      TPR_11   14 ieaYkkAlkldP 25  
                   + Y+kAl+l+ 
  EFC38028.1 1073 FKLYQKALDLSK 1084
                  578******986 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.011
      TPR_11    2 dayyeqGkyeeAieaYkkAl 21  
                  ++++ +G+y eA e Y +A 
  EFC38028.1 1141 RMFFNKGNYQEAHELYLEAS 1160
                  689***************95 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 9.7e-05
      TPR_11   12 eAieaYkkAlkldPdnaeayynLGlayykq 41  
                  eAi +Y kA++ d +n ea++ LG++y ++
  EFC38028.1 1188 EAIIWYLKAVESDVKNSEALFRLGYLYKEL 1217
                  89*************************875 PP

>> YlbE  YlbE-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   2.4    0.0004      0.42      26      60 ..     853     890 ..     842     891 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.0004
        YlbE  26 elekemkekYk...ktipdkvekisnslqmvsmllevl 60 
                 + +k m + Yk   +ti  +++k ++ +qmvs +++ +
  EFC38028.1 853 DYQKRMEDIYKelfQTIFKQINKKKQRVQMVSEMMDLF 890
                 4444555555533369999****************986 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.76     8e+02       6      25 ..     750     769 ..     749     770 .. 0.89
   2 ?   -2.0   0.0       3.8     4e+03      52      64 ..     850     862 ..     846     863 .. 0.82
   3 ?    2.2   0.0      0.18   1.9e+02      23      34 ..    1072    1083 ..    1067    1093 .. 0.83
   4 ?    9.2   0.2    0.0012       1.2      16      34 ..    1145    1163 ..    1145    1166 .. 0.90
   5 ?   -0.6   1.1       1.3   1.4e+03      18      33 ..    1218    1233 ..    1212    1238 .. 0.86
   6 ?    0.7   0.0      0.52   5.5e+02      19      31 ..    1257    1269 ..    1254    1271 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.76
         MIT   6 elvkkAveeDnagnyeeAle 25 
                  l+++A+++ ++gny+ A++
  EFC38028.1 750 TLINRAIDAPKKGNYSVAVN 769
                 589*************9985 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 3.8
         MIT  52 kieeYleRaeeLk 64 
                 k + Y++R+e + 
  EFC38028.1 850 KPNDYQKRMEDIY 862
                 6689******986 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.18
         MIT   23 AlelYkealelL 34  
                  A++lY++al+l 
  EFC38028.1 1072 AFKLYQKALDLS 1083
                  9********985 PP

  == domain 4  score: 9.2 bits;  conditional E-value: 0.0012
         MIT   16 nagnyeeAlelYkealelL 34  
                  n+gny+eA elY ea   +
  EFC38028.1 1145 NKGNYQEAHELYLEASTKF 1163
                  79*************9877 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 1.3
         MIT   18 gnyeeAlelYkealel 33  
                  ++ ++A ++Y++a el
  EFC38028.1 1218 KDNQKAWDYYQKAAEL 1233
                  6779999****99986 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.52
         MIT   19 nyeeAlelYkeal 31  
                  ny+ A+e+Y+++ 
  EFC38028.1 1257 NYSLAFEWYCKSA 1269
                  9*********986 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.041        43      24      61 ..    1132    1170 ..    1122    1172 .. 0.81
   2 ?    3.6   0.7     0.088        93      14      61 ..    1194    1240 ..    1185    1243 .. 0.82
   3 ?   -1.7   0.1         4   4.3e+03      14      37 ..    1304    1324 ..    1299    1330 .. 0.62

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.041
      TPR_19   24 naearllLAeallalgqldeAealLdalpeedpdd.ary 61  
                  + ea+ + A+  ++ g+++eA +l  ++  ++ d+ ++y
  EFC38028.1 1132 HIEALRNVARMFFNKGNYQEAHELYLEASTKFNDSdSQY 1170
                  66788889999999*******999999999999954887 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.088
      TPR_19   14 leqalqedpknaearllLAeallalgqldeAealLdalpeedpddary 61  
                  l++  + d kn+ea+ +L  ++ +l++ ++A +  +++ e   ++a+y
  EFC38028.1 1194 LKA-VESDVKNSEALFRLGYLYKELKDNQKAWDYYQKAAELGNNEAQY 1240
                  444.578889*********************99888888888888777 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 4
      TPR_19   14 leqalqedpknaearllLAealla 37  
                  l++a     +n++a l+L ++l +
  EFC38028.1 1304 LKAA---QQQNSDAELALGKLLCE 1324
                  4454...44566666666666655 PP

>> PRD  PRD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       1.8   1.9e+03      54      78 ..     392     416 ..     389     419 .. 0.87
   2 ?    3.1   0.2      0.11   1.2e+02      33      80 ..     496     543 ..     466     545 .. 0.83
   3 ?    5.6   0.8     0.018        19      22      69 ..     831     878 ..     825     903 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.8
                 HHHHHHHHHHHHHHHHHHTST--HH CS
         PRD  54 pkefeiakeileeleeeldielped 78 
                  k +ei+++  + l+ + + +++ed
  EFC38028.1 392 MKVYEIVRKSKNLLKYQSKQSMDED 416
                 589*************999999998 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.11
                 HHHHTT.--HHHHHHHHHHHHTHHHHHHH.HHHHHHHHHHHTST--HHHH CS
         PRD  33 eRlkeg.itienplleeikekypkefeia.keileeleeeldielpedEi 80 
                  R+++  ++i +   +e+k+   k+fei  +++++++e+ ++  ++e++i
  EFC38028.1 496 ARINSTiMHILEGCEDETKQ--GKIFEILnQKACKHIENLMKNYISESDI 543
                 57777777888888899999..9****98568**************9987 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.018
                 HHHHHHHHHHHHHHHTT--HHHHHHHHHHHHTHHHHHHHHHHHHHHHH CS
         PRD  22 erLitHlkfaieRlkegitienplleeikekypkefeiakeileelee 69 
                 + Lit +k+ i  + +++t  n++++ +++ y+++f+++ + +++ ++
  EFC38028.1 831 QHLITFIKYKIANIFKNNTKPNDYQKRMEDIYKELFQTIFKQINKKKQ 878
                 67999999999999999********************98776666555 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       2.9     3e+03       1      23 [.    1134    1156 ..    1134    1163 .. 0.80
   2 ?   11.3   1.7    0.0004      0.42       1      27 [.    1205    1231 ..    1205    1233 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 2.9
                  HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6    1 dAlyklalsyrklgdtdkAleal 23  
                  +Al + a+ +++ g++++A e++
  EFC38028.1 1134 EALRNVARMFFNKGNYQEAHELY 1156
                  577788999**988****96665 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.0004
                  HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6    1 dAlyklalsyrklgdtdkAlealerli 27  
                  +Al++l+++y++l+d +kA +++++  
  EFC38028.1 1205 EALFRLGYLYKELKDNQKAWDYYQKAA 1231
                  7************9*********9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1384 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       941  (0.0524848); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.82u 0.26s 00:00:01.08 Elapsed: 00:00:00.43
# Mc/sec: 9756.54
//
Query:       EFC38029.1  [L=681]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-31  105.9  18.5     0.0018   18.2   0.0   11.2 11  LRR_6            Leucine Rich repeat
    3.4e-25   87.6  12.8    6.2e-07   29.1   0.8    5.2  5  LRR_8            Leucine rich repeat
    6.2e-20   71.0  21.5    5.4e-05   23.5   0.8    6.9  9  LRR_4            Leucine Rich repeats (2 copies)
    1.1e-10   42.2   0.0      2e-10   41.4   0.0    1.4  1  Peptidase_C39_2  Peptidase_C39 like family
    3.3e-07   29.9  12.1        8.8    7.3   0.0   10.1 12  LRR_1            Leucine Rich Repeat
    6.1e-05   22.6   3.8       0.12   11.9   0.5    2.5  2  LRR_9            Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0    0.0011       3.4       2      17 ..     412     427 ..     411     428 .. 0.93
   2 !    5.2   0.0     0.009        27       4      15 ..     438     449 ..     435     454 .. 0.87
   3 ?    0.4   0.0      0.29   8.7e+02       5      15 ..     463     473 ..     460     478 .. 0.82
   4 !   11.6   0.1   7.7e-05      0.23       3      24 .]     485     506 ..     483     506 .. 0.93
   5 !   13.3   0.0   2.3e-05     0.068       5      24 .]     511     530 ..     510     530 .. 0.91
   6 !   16.8   0.1   1.6e-06    0.0049       3      23 ..     533     553 ..     531     554 .. 0.87
   7 !    5.9   0.0    0.0051        15       5      23 ..     559     577 ..     556     578 .. 0.92
   8 !    6.0   0.0    0.0049        15       5      23 ..     583     601 ..     580     602 .. 0.90
   9 !   18.2   0.0   6.1e-07    0.0018       3      20 ..     605     622 ..     603     626 .. 0.88
  10 !   12.5   0.1   3.8e-05      0.11       4      23 ..     630     649 ..     628     649 .. 0.90
  11 !    9.6   0.1   0.00033      0.99       4      18 ..     654     668 ..     651     668 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0011
       LRR_6   2 nthLteLdLsgNdIgD 17 
                 + hL+ L++ +++I+D
  EFC38029.1 412 CEHLRRLHVVFCKISD 427
                 78*************9 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.009
       LRR_6   4 hLteLdLsgNdI 15 
                  L+eL++sgN +
  EFC38029.1 438 QLKELNVSGNRF 449
                 59********87 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.29
       LRR_6   5 LteLdLsgNdI 15 
                 Lt Ld+s+ ++
  EFC38029.1 463 LTILDMSYTKL 473
                 89999998765 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 7.7e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L +++Nd+g +Gae +a
  EFC38029.1 485 RNLTSLRINDNDLGIQGAELIA 506
                 79*****************997 PP

  == domain 5  score: 13.3 bits;  conditional E-value: 2.3e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+eL + +N+IgDeG+ +++
  EFC38029.1 511 LRELFIGSNNIGDEGMYSIS 530
                 89999***********9986 PP

  == domain 6  score: 16.8 bits;  conditional E-value: 1.6e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt+Ld+s+N+Ig eGa ++
  EFC38029.1 533 KNLTKLDVSSNGIGEEGANSI 553
                 69***************9766 PP

  == domain 7  score: 5.9 bits;  conditional E-value: 0.0051
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt  ++ +N Ig +Gae++
  EFC38029.1 559 LTFINVGFNLIGQQGAESI 577
                 8899*************98 PP

  == domain 8  score: 6.0 bits;  conditional E-value: 0.0049
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L ++ ++Ig  Ga+ +
  EFC38029.1 583 LTTLLINNCEIGPTGAKFI 601
                 99999***********977 PP

  == domain 9  score: 18.2 bits;  conditional E-value: 6.1e-07
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                 + +teLd+s NdI+DeGa
  EFC38029.1 605 QRVTELDISLNDIQDEGA 622
                 678**************8 PP

  == domain 10  score: 12.5 bits;  conditional E-value: 3.8e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +L  L ++ N+I+DeG++a+
  EFC38029.1 630 KLSILYVNNNEITDEGLKAI 649
                 5778999***********98 PP

  == domain 11  score: 9.6 bits;  conditional E-value: 0.00033
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +L+ Ld+sgN+I+De
  EFC38029.1 654 NLQLLDVSGNKISDE 668
                 7999**********8 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.0   4.9e-05      0.15       2      38 ..     414     450 ..     413     455 .. 0.94
   2 !   23.4   0.1   1.2e-08   3.7e-05      22      61 .]     458     497 ..     453     497 .. 0.97
   3 !   26.4   0.2   1.5e-09   4.4e-06       2      61 .]     510     569 ..     509     569 .. 0.97
   4 !   21.4   0.3   5.3e-08   0.00016       2      61 .]     582     641 ..     581     641 .. 0.98
   5 !   29.1   0.8   2.1e-10   6.2e-07       2      61 .]     606     665 ..     605     665 .. 0.97

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.9e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 +L++L++ + ++++ + ++ +++++Lk+L+ s N+ +
  EFC38029.1 414 HLRRLHVVFCKISDREISVISQMKQLKELNVSGNRFS 450
                 8*********************************876 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 1.2e-08
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 k++++L++Ld+s+ +l+ l+ ++ sg+++L+sL +++N+L
  EFC38029.1 458 KDMKQLTILDMSYTKLKCLDVEVVSGMRNLTSLRINDNDL 497
                 799***********************************98 PP

  == domain 3  score: 26.4 bits;  conditional E-value: 1.5e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L++L + +N++ + +  + ++++nL+ Ld s+N +    ++++s+L+ L+++++  N +
  EFC38029.1 510 QLRELFIGSNNIGDEGMYSISHMKNLTKLDVSSNGIGEEGANSISQLKGLTFINVGFNLI 569
                 79******************************************************9986 PP

  == domain 4  score: 21.4 bits;  conditional E-value: 5.3e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L ++n  +   + ++ ++++++++Ld+s N ++   ++ +s L++L  L++++N +
  EFC38029.1 582 QLTTLLINNCEIGPTGAKFISKMQRVTELDISLNDIQDEGAHYISELEKLSILYVNNNEI 641
                 79********************************************************87 PP

  == domain 5  score: 29.1 bits;  conditional E-value: 2.1e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++t+Ld+s N +++ + +  + l++L +L+ +nN++t    +a+ ++++L+ Ld+sgN++
  EFC38029.1 606 RVTELDISLNDIQDEGAHYISELEKLSILYVNNNEITDEGLKAITQMKNLQLLDVSGNKI 665
                 689*******************************************************97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.2       2.6   7.8e+03       2      11 ..      59      68 ..      58      70 .. 0.59
   2 !   13.4   0.0   2.7e-05     0.079       2      38 ..     414     448 ..     413     454 .. 0.83
   3 !   17.9   0.2     1e-06    0.0031       1      39 [.     461     497 ..     461     501 .. 0.87
   4 !   15.2   0.7     7e-06     0.021       2      37 ..     486     522 ..     485     531 .. 0.81
   5 !   18.7   0.1   5.7e-07    0.0017       2      35 ..     510     544 ..     509     549 .. 0.86
   6 !   16.2   0.2   3.6e-06     0.011       1      37 [.     533     570 ..     533     581 .. 0.86
   7 ?    4.6   0.1     0.016        48       2      39 ..     582     617 ..     581     629 .. 0.78
   8 !   13.8   0.2     2e-05     0.059       2      38 ..     606     643 ..     605     648 .. 0.80
   9 !   23.5   0.8   1.8e-08   5.4e-05       2      38 ..     630     667 ..     629     671 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.6
                S--EEE--SS CS
       LRR_4  2 nLevLdLsnN 11
                n + L ++nN
  EFC38029.1 59 NIRRLKCRNN 68
                5566666666 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 2.7e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +L+ L+   ++++d +   ++++++LkeL++sgN    +
  EFC38029.1 414 HLRRLHVVFCKISDREIsvISQMKQLKELNVSGN----R 448
                 6999999999999888865668************....3 PP

  == domain 3  score: 17.9 bits;  conditional E-value: 1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++Ld s ++l+ ++    +++ nL++L +++N    dl
  EFC38029.1 461 KQLTILDMSYTKLKCLDVevVSGMRNLTSLRINDN----DL 497
                 58****************65336*********999....77 PP

  == domain 4  score: 15.2 bits;  conditional E-value: 7e-06
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 nL++L +++N l  i++   +++l++L+eL + +N +i+
  EFC38029.1 486 NLTSLRINDNDLG-IQGaelIAQLDQLRELFIGSN-NIG 522
                 9**********88.666464558*********444.565 PP

  == domain 5  score: 18.7 bits;  conditional E-value: 5.7e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 +L++L +++N++ d +   ++ ++nL++Ld+s+N  
  EFC38029.1 510 QLRELFIGSNNIGDEGMysISHMKNLTKLDVSSN-G 544
                 69************99965446*********999.4 PP

  == domain 6  score: 16.2 bits;  conditional E-value: 3.6e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +nL++Ld s+N + + +   +++l+ L+ +++ g+nli+
  EFC38029.1 533 KNLTKLDVSSNGIGEEGAnsISQLKGLTFINV-GFNLIG 570
                 79************988876667*********.777985 PP

  == domain 7  score: 4.6 bits;  conditional E-value: 0.016
                 S--EEE--SS---.E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqlt.dipl..leklpnLkeLdLsgNnlitdl 39 
                 +L++L ++n+ +  + +   ++k+   +eLd+s N    d+
  EFC38029.1 582 QLTTLLINNCEIGpT-GAkfISKMQRVTELDISLN----DI 617
                 6999*****999944.4464446999****99656....66 PP

  == domain 8  score: 13.8 bits;  conditional E-value: 2e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 + ++Ld+s N ++d +   ++ l +L  L++ +Nn itd
  EFC38029.1 606 RVTELDISLNDIQDEGAhyISELEKLSILYV-NNNEITD 643
                 689*****88****99965335999999999.7779987 PP

  == domain 9  score: 23.5 bits;  conditional E-value: 1.8e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +L +L+ +nN +td +l  + +++nL+ Ld+sgN +i+d
  EFC38029.1 630 KLSILYVNNNEITDEGLkaITQMKNLQLLDVSGN-KISD 667
                 7889**********99987669************.5543 PP

>> Peptidase_C39_2  Peptidase_C39 like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.4   0.0   6.5e-14     2e-10       3     144 .]     270     402 ..     268     402 .. 0.86

  Alignments for each domain:
  == domain 1  score: 41.4 bits;  conditional E-value: 6.5e-14
  Peptidase_C39_2   3 vplynQlde..............lpngCeptslamvlsylgk.kvtqnelakelktnssgdpntgfvgnitdksglgvynepivklaekyglkv 81 
                      +  ++Q+d+              +++gC  +++++ l+ lg+ ++t++e++++lk+n       gf     ++ +l +++++ ++++ k+++  
       EFC38029.1 270 FTVFKQCDTrwgslklgsgsstiCKAGCLLSAITSGLKGLGRtEWTPKEMNEWLKKNR------GF-----KDGNLFIWASINKQFGVKFSG-- 350
                      6678888877888888888888899*****************78*************8......55.....344556666655667778776.. PP

  Peptidase_C39_2  82 sdtrgssieevkkeidagkPvvvsvttfkplndgeikftssgHlvvitGYdekgkrvyvnDPa 144
                          +++++  ++++++g+ v++ +  +kp+      +++++H+v+ tGYd+++k + v D+a
       EFC38029.1 351 ---ITTDMSVTIRNLCEGRMVILKL--IKPP------GKKTEHFVLATGYDSQTKSFSVVDSA 402
                      ...899*******************..6766......9***********************86 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       2.7   8.1e+03       1      17 [.      59      75 ..      59      80 .. 0.80
   2 ?   -0.7   0.0       1.2   3.7e+03       1      16 [.     414     429 ..     414     435 .. 0.78
   3 ?    5.4   0.0     0.012        36       1      14 [.     438     450 ..     438     458 .. 0.81
   4 ?   -0.6   0.0       1.1   3.4e+03       2      15 ..     463     476 ..     462     482 .. 0.77
   5 ?    2.4   0.1      0.12   3.6e+02       1      14 [.     486     498 ..     486     506 .. 0.85
   6 ?    1.9   0.0      0.18   5.4e+02       1      20 [.     510     529 ..     510     532 .. 0.76
   7 !    7.3   0.0    0.0029       8.8       1      22 [.     534     555 ..     534     556 .. 0.91
   8 ?   -1.1   0.0       1.7   5.1e+03       2      22 ..     559     579 ..     558     580 .. 0.84
   9 ?    0.1   0.0      0.69     2e+03       2      12 ..     583     593 ..     582     604 .. 0.79
  10 ?   -0.5   0.0       1.1   3.3e+03       3      21 ..     608     626 ..     606     628 .. 0.76
  11 ?    1.2   0.0       0.3     9e+02       1      16 [.     630     645 ..     630     650 .. 0.80
  12 ?    4.8   0.0      0.02        60       1      15 [.     654     668 ..     654     673 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.7
       LRR_1  1 nLrhLdLsnnpllglpp 17
                n r+L  +nn  +g++ 
  EFC38029.1 59 NIRRLKCRNNKSPGFIV 75
                67999999**9988775 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.2
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +Lr+L++  + +++ +
  EFC38029.1 414 HLRRLHVVFCKISDRE 429
                 69*****999986554 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.012
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++L++s+n++ +
  EFC38029.1 438 QLKELNVSGNRF-S 450
                 59********98.3 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 1.1
       LRR_1   2 LrhLdLsnnpllgl 15 
                 L+ Ld+s+  l +l
  EFC38029.1 463 LTILDMSYTKLKCL 476
                 88999998887655 PP

  == domain 5  score: 2.4 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL++L +++n l g
  EFC38029.1 486 NLTSLRINDNDL-G 498
                 8*********99.3 PP

  == domain 6  score: 1.9 bits;  conditional E-value: 0.18
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr+L +++n++++ +  s+
  EFC38029.1 510 QLRELFIGSNNIGDEGMYSI 529
                 59*****9999977665555 PP

  == domain 7  score: 7.3 bits;  conditional E-value: 0.0029
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++Ld+s+n ++  ++ns++ 
  EFC38029.1 534 NLTKLDVSSNGIGEEGANSISQ 555
                 8***********9999999986 PP

  == domain 8  score: -1.1 bits;  conditional E-value: 1.7
       LRR_1   2 LrhLdLsnnpllglppnsfqn 22 
                 L+ ++++ n +++ +++s+  
  EFC38029.1 559 LTFINVGFNLIGQQGAESIGE 579
                 7889******99999888865 PP

  == domain 9  score: 0.1 bits;  conditional E-value: 0.69
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L ++n+ +
  EFC38029.1 583 LTTLLINNCEI 593
                 999******97 PP

  == domain 10  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1   3 rhLdLsnnpllglppnsfq 21 
                 ++Ld+s n + + ++ +++
  EFC38029.1 608 TELDISLNDIQDEGAHYIS 626
                 69****9999777776665 PP

  == domain 11  score: 1.2 bits;  conditional E-value: 0.3
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L  L+++nn +++ +
  EFC38029.1 630 KLSILYVNNNEITDEG 645
                 6889******997655 PP

  == domain 12  score: 4.8 bits;  conditional E-value: 0.02
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL+ Ld+s+n +++ 
  EFC38029.1 654 NLQLLDVSGNKISDE 668
                 8*********98654 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.5     4e-05      0.12      22     125 ..     440     545 ..     422     564 .. 0.80
   2 !   11.4   0.2   5.8e-05      0.17      62     149 ..     579     662 ..     561     675 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4e-05
       LRR_9  22 reldlrgykipvienlGat..ldqfdtidlsdndirkld..gfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkkle 116
                 +el++ g++++  e +     + q+  +d+s  +++ ld   +  ++ l +l +n+n +   + +l   l +l+el + +n++ + +    + ++k+l+
  EFC38029.1 440 KELNVSGNRFSF-ESVCKIkdMKQLTILDMSYTKLKCLDveVVSGMRNLTSLRINDNDLGIQGAELIAQLDQLRELFIGSNNIGDEGM-YSISHMKNLT 536
                 677777777764.444443015589999***99999876226788**************************************99765.7889999999 PP

       LRR_9 117 llsllknpv 125
                  l + +n +
  EFC38029.1 537 KLDVSSNGI 545
                 888877766 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 5.8e-05
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldfrk 149
                  l++l tll+nn  i  ++ ++   + +++el ++ n +q+ +       +++le ls+l     + ++  l  i ++k+l+lld   
  EFC38029.1 579 ELEQLTTLLINNCEIGPTGAKFISKMQRVTELDISLNDIQDEGA----HYISELEKLSILYVNNNEITDEGLKAITQMKNLQLLDVSG 662
                 57788888888877776666666666666666666666665554....5566666666666666666666788888888888888654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (681 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1032  (0.0575604); expected 358.6 (0.02)
Passed bias filter:                      646  (0.036031); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.43
# Mc/sec: 4783.78
//
Query:       EFC38030.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-25   89.5  10.5    1.9e-25   89.5  10.5    1.9  2  BioY      BioY family
  ------ inclusion threshold ------
       0.12   12.3   0.1       0.25   11.3   0.1    1.4  1  PBECR3    phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3
        1.3    9.5   6.4        3.1    8.3   0.4    2.5  2  STIMATE   STIMATE family


Domain annotation for each model (and alignments):
>> BioY  BioY family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.17     1e+03     107     129 ..     131     153 ..     115     162 .. 0.61
   2 !   89.5  10.5   3.2e-29   1.9e-25       2     131 ..     168     310 ..     167     313 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.17
        BioY 107 alaagvlpfipgdlvkavlaall 129
                 +++ +v+pfi   l+ ++ a+l+
  EFC38030.1 131 IVSNAVVPFISNMLLVIFGACLM 153
                 45555666655555555554443 PP

  == domain 2  score: 89.5 bits;  conditional E-value: 3.2e-29
        BioY   2 gpvpitlqtlavllaglllgprrgalavllYlllGal.glPvfag.g.gGlavllgptgGYllGFlvaalvvgll......kk.laelllallagllvi 90 
                 + vpit qt++vl +g l g   + l++llYl++G +  +P+f++ + g l  + + + G+l+GF++ al++g++       + +++ ll+l++ ++v+
  EFC38030.1 168 SAVPITGQTFGVLWLGSLTGFVIAPLSILLYLFCGSVlDIPWFSNqThGNLVLFQSSSSGFLIGFVFSALICGWFcskmasDRtIMMNLLMLCLSNAVT 266
                 68*********************************8759******6556677777789*****************9988742367777888889***** PP

        BioY  91 yalGvlwlal.v..lslaaalaagvlpfipgdlvkavlaallak 131
                 +++G+ wla+ v  l l++ +  g++pf+pg+++k+ l+ ++++
  EFC38030.1 267 FVFGCGWLAFgVpnLGLSKGIEKGLVPFLPGETIKISLVLVMIR 310
                 **********6366899*********************999876 PP

>> PBECR3  phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   4.2e-05      0.25       9      43 ..      24      58 ..      18      74 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 4.2e-05
      PBECR3  9 eeiakklgldlsgtkilidpgaikHilkrHgnqst 43
                +ei++klg+++s+ + +i +++i++i +r g++++
  EFC38030.1 24 KEIERKLGYKVSQQHLTIESENISQIRRRRGQDHS 58
                59****************************77665 PP

>> STIMATE  STIMATE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.4   0.00052       3.1      63     116 ..      93     146 ..      74     149 .. 0.92
   2 ?    3.4   1.1     0.018   1.1e+02       1      92 [.     239     327 ..     239     338 .. 0.66

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00052
     STIMATE  63 lvlmKlvvllllllfeevlakvaellLswlesnpklqlllvmvivPlilNvlqf 116
                 ++lm+ v  l+l+  e  +  v+++ L++ + +p l+ ++  ++vP+i N+l +
  EFC38030.1  93 MALMRSVFDLILIKSERRFDLVKKWHLKLGTCHPLLKTIVSNAVVPFISNMLLV 146
                 678999999999999999********************************9865 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.018
     STIMATE   1 CswYflnlllDttlGvlilylllkllekllkklkleslesGnYgkpkalsawlkqllvyllilvlmKlvvllllllfeevlakvaellLswl 92 
                 C w+  +++ D t+ + +l+l+l+    ++  +++ ++   n g     +   k l+ +l + ++   +vl+++ l  +vl+++++++L+ l
  EFC38030.1 239 CGWFCSKMASDRTIMMNLLMLCLSNAVTFVFGCGWLAFGVPNLGLS---KGIEKGLVPFLPGETIKISLVLVMIRLSWFVLFQIRKVVLKHL 327
                 9999999999999999999999998888888888777777777553...3444555555555555444455555554455555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2412.33
//
Query:       EFC38031.1  [L=557]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      3e-09   37.2   7.8      3e-09   37.2   7.8    2.8  2  RGS            Regulator of G protein signaling domain
    2.8e-08   33.7   1.7      5e-07   29.7   0.8    3.0  2  DEP            Domain found in Dishevelled, Egl-10, and Pleck


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.3     0.033   2.9e+02      20      48 ..     201     227 ..     191     283 .. 0.77
   2 !   37.2   7.8   3.3e-13     3e-09       1     117 [.     419     540 ..     419     541 .. 0.94

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.033
                 HHTTCTHHHHHHHHHHHHHTSSHHHHHHH CS
         RGS  20 esefseenlsFwlaveefkkakeqeelkk 48 
                 +++f++ n sF+  ++++k+a e +++ +
  EFC38031.1 201 KKQFKDSNNSFYGLCKNLKQA-E-SDFRN 227
                 788999**************9.2.22222 PP

  == domain 2  score: 37.2 bits;  conditional E-value: 3.3e-13
                 -HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS....STTTTTTHHH CS
         RGS   1 sleslledqpgrslFreFlesefseenlsFwlaveefkka..keqeelkkkakeIyneylapsspkelnidkklreelekrleke....qpsrklfeea 93 
                 sl++ l d + r+ F++F ++e+s+en+ F+++v +f ++   ++ee  + a ++y+ ++ + s  +ln+++kl ++ ++ + ++     +   l++ea
  EFC38031.1 419 SLSEFLRDTYMREQFKTFSKDEYSQENIIFYEEVLKFLNSifLSEEEQRALALKLYQLFIPSTSVYQLNLPSKLLAKFKDEFDTDfdnvANVVLLYKEA 517
                 578899**********************************99889999999*********99999****************99999998999******* PP

                 HHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS  94 qeevfellekdsypkFlkselylr 117
                  +e+  +++ d y++F   + y++
  EFC38031.1 518 LTEIEHVMK-DTYTRFKMGKEYQK 540
                 ******996.89****99988887 PP

>> DEP  Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.8   5.6e-11     5e-07       2      70 ..     129     212 ..     128     214 .. 0.95
   2 ?   -1.4   0.0      0.28   2.5e+03      33      56 ..     464     487 ..     451     500 .. 0.67

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 5.6e-11
                 S-SCEEECTTEEESSE-HHHHHHHHHHHHTS................SSSHHHHHHHHHHHHHCTSCECSSSSHCC--SSSSS-E CS
         DEP   2 vklkdrrkhlktypncftGseavdWLldnld................iedreeAvalgqlLldqgliehvedkhqeFrdskqafY 70 
                 + +kd+r+ lk+++ +ftG++ +  + + ++                 e r   + ++q Ll++++i h++ k+q F+ds+++fY
  EFC38031.1 129 ISVKDNRYLLKSFKESFTGKDSTLLISQIIKaetivesnngfglsqsDEIRLFSQCFCQILLNYKFIFHMTHKKQ-FKDSNNSFY 212
                 789****************************************9998888999999*******************.********* PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.28
                 SSSHHHHHHHHHHHHHCTSCECSS CS
         DEP  33 iedreeAvalgqlLldqgliehve 56 
                  e+r+ A++l ql++ +  +++++
  EFC38031.1 464 EEQRALALKLYQLFIPSTSVYQLN 487
                 577888888888887666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (557 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       866  (0.0483016); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.26s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 3679.40
//
Query:       EFC38032.1  [L=518]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.4e-87  291.9   0.0    1.1e-86  291.3   0.0    1.2  1  HSP70           Hsp70 protein
    1.3e-06   27.5   0.0    2.1e-06   26.8   0.0    1.2  1  MreB_Mbl        MreB/Mbl protein
  ------ inclusion threshold ------
       0.12   11.6   0.1        3.9    6.7   0.0    2.7  3  FAE1_CUT1_RppA  FAE1/Type III polyketide synthase-like protei


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  291.3   0.0   1.9e-90   1.1e-86       1     488 [.       9     510 ..       9     516 .. 0.90

  Alignments for each domain:
  == domain 1  score: 291.3 bits;  conditional E-value: 1.9e-90
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXT...........T.SEEETHHHHH..CTTTTGGGEEEXGGGTTTXBTTSHH..HHHHHT CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrttPsvvaFtk...........k.erlvGeaAkr..qavtnpkntvfsvKrliGrkfsdpe..vqkeik 83 
                 ++ iD G   + vav  ++++e i n+ gn  tP ++aF +           +   l+Ge+A +      +p   + ++K+liG++ +d++  +  +++
  EFC38032.1   9 IVAIDFGGSHCRVAVYLEDHVEYIPNKLGNYETPTCIAFVSsssllddssmsNsRILIGEEALEfySKSEDPYCLFWDFKQLIGKACDDEDdeLILKSN 107
                 578************************************76222221111112134789999873245678888999*********9886511556889 PP

                 TXSSEEEEETTSBEEEEEEETTE..EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTC CS
       HSP70  84 elpykvvkkengkavveveaage..kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGld 180
                 e+p+++ +k+++ + ++v  ++e  + + +++ + +Lk+lke+ae yl++ vtd v+++P Yf + qR  +k   +  G+   R+v ++ Aa   Y + 
  EFC38032.1 108 EWPFRIIRKQDKTIRLSVCKEEEyeEISVNEMIGLILKQLKEDAERYLKRAVTDLVVSIPNYFSNHQRIEMKKVVESIGVTNSRLVHDTSAACFQY-IW 205
                 9**************99998877889999*******************************************************************.66 PP

                 CSSSCEEEEEEEEXSSXEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEE CS
       HSP70 181 kkdkernvlvyDlGggtfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrlkeaaekaKkeLSsskqteinlei 279
                 k   e+ v v+DlG +   +S+  +++Gv++ k+  g  + GG + De lv +++eef k  +  l++++  +++++ a+e+aKk+LS+  + +++l+i
  EFC38032.1 206 KYRGEKRVFVFDLGRSGCSASVFLVDNGVVDTKSSDGLPNHGGAKLDESLVSYCCEEFYKLFKKRLQENPVSMRKMQVACEEAKKKLST--ELQTQLSI 302
                 6667*************************************************************************************..889999** PP

                 EEEETTTEEEEEEEEHHHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTTCHHB.SSSHTTTHHHHHHHHHHHHHCT CS
       HSP70 280 etvdedgkdlseklsRakfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfgkeps.ktvnpDeavaiGAAvqagvlsg 377
                 +++++ g d+++ l+R+kfe+l++d+++++l+   k+++ a+++keei + +++GG   iPk+++l+  +f k+ + + + p   v  GAA+q+g+l+ 
  EFC38032.1 303 KSLMD-GIDFEIVLTRSKFEDLNTDFFSKCLSLADKVIRRANCSKEEIADAIIIGGGCEIPKLKQLITTYFCKSIHpRPIYPN-PVVFGAAIQGGILAN 399
                 ****9.*******************************************************************9983456665.5669**********9 PP

                 CGCSHCCEEEEBESS-EEEEET.TTEEEEEESTTCBSSEEEEEEEEES..STTSS.SEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEE CS
       HSP70 378 eeevkdllllDvtpLslgietl.ggvmtkliernttiptkksqvfsta..adnqt.aveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfd 472
                     kdlll  vt+  +g e++ gg    l ++ + ip ++++ fs+    +nq+ av++++++g+ + ++dn+l+g  ++++i+ +   +++i  tf 
  EFC38032.1 400 --FEKDLLLIEVTSRNIGCEISiGGDLMILLKKDNSIPCSSEREFSLPpnPNNQKkAVSLKIYEGDSKKASDNELIGIVKITEITEL--SSSNISLTFG 494
                 ..89***********999998735557788888899**********9622457777*****************************55..5789****** PP

                 EETTSCEEEEEEETTT CS
       HSP70 473 idanGiltvsakdket 488
                 +d +Gil v++k+k+ 
  EFC38032.1 495 LDTDGILYVQSKSKKP 510
                 ************9976 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.8   0.0   3.5e-10   2.1e-06      76     297 ..     138     372 ..     131     394 .. 0.78

  Alignments for each domain:
  == domain 1  score: 26.8 bits;  conditional E-value: 3.5e-10
                 HHHHHHHHHHHT....SS-SS--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-EEEEE.EETTEEEE CS
    MreB_Mbl  76 ellkyfikkvkk....kkslskprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglpveepsgnmvvdiGggttevav.islggivt 169
                 e++  ++k++k+      + + + +v+++P+  ++ +r  +k++++++G ++  l+ ++ aA      +    +  +v d+G    + +v +  +g+v 
  EFC38032.1 138 EMIGLILKQLKEdaerYLKRAVTDLVVSIPNYFSNHQRIEMKKVVESIGVTNSRLVHDTSAACFQYIWKYRGEKRVFVFDLGRSGCSASVfLVDNGVVD 236
                 5555555555553200334455678***************************************999999999999******65555555266789999 PP

                 EEEE....S-SHHHHHHHHHHHHHHHHSEE--HHHHH....HHHHHH-BSS--HHHH...EEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHH CS
    MreB_Mbl 170 sksv....rvaGdeldeaiikyirkkynlliGertae....kikieigsavkeeeee...kmeikGrdlvtglpkevevsseevrealkepvsaiveav 257
                 +ks       +G +lde++++y  +++  l  +r  e      k+++++   +++ +   +++++ + l+ g+  e+ ++ ++ ++  ++ +s+ ++ +
  EFC38032.1 237 TKSSdglpNHGGAKLDESLVSYCCEEFYKLFKKRLQEnpvsMRKMQVACEEAKKKLStelQTQLSIKSLMDGIDFEIVLTRSKFEDLNTDFFSKCLSLA 335
                 9885333368************99987666555544411115678887766555544457999999********************************* PP

                 HHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHH CS
    MreB_Mbl 258 kevLektppeLaadivdrgivltGGgallkgldkllseet 297
                  +v++++    +++ +  +i++ GGg  +  l++l++  +
  EFC38032.1 336 DKVIRRANC--SKEEIADAIII-GGGCEIPKLKQLITTYF 372
                 ****98654..45555556776.99999******998765 PP

>> FAE1_CUT1_RppA  FAE1/Type III polyketide synthase-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0     0.061   3.7e+02       8      46 ..      22      60 ..      17      71 .. 0.88
   2 ?    6.7   0.0   0.00065       3.9     106     153 ..     184     231 ..     129     235 .. 0.79
   3 ?    0.1   0.0     0.068   4.1e+02      74     145 ..     279     359 ..     266     362 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.061
  FAE1_CUT1_RppA  8 kvYlvdyscykpederkvstetfleiikrvkkldeesld 46
                    +vYl d+  y p++  + +t t+++++++++ ld++s++
      EFC38032.1 22 AVYLEDHVEYIPNKLGNYETPTCIAFVSSSSLLDDSSMS 60
                    79*****************************99999886 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.00065
  FAE1_CUT1_RppA 106 dilvvncslfsptPslsamvvnryklredvksynLsgmGCsAglisid 153
                      i v+n+ l   t +     + +y+  + v +++L+  GCsA++  +d
      EFC38032.1 184 SIGVTNSRLVHDTSAACFQYIWKYRGEKRVFVFDLGRSGCSASVFLVD 231
                     4668888888888888889999*********************99887 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.068
  FAE1_CUT1_RppA  74 ktlaeareEaeevlfgavdella.ktkvspkdidilvv.......ncslfsptPslsamvvnrykl.redvksynLsgmGC 145
                     ++++ a eEa++ l + ++  l+ k+ ++  d +i+++       n+  fs   sl++ v++r +  +e++    + g GC
      EFC38032.1 279 RKMQVACEEAKKKLSTELQTQLSiKSLMDGIDFEIVLTrskfedlNTDFFSKCLSLADKVIRRANCsKEEIADAIIIGGGC 359
                     567778888888888777755542556667777777643333333788999999999999999876356677766666677 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (518 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       821  (0.0457917); expected 358.6 (0.02)
Passed bias filter:                      574  (0.0320152); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 2976.88
//
Query:       EFC38033.1  [L=428]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.9e-35  122.4  28.6    3.2e-35  121.7  28.6    1.4  1  TRAM_LAG1_CLN8  TLC domain


Domain annotation for each model (and alignments):
>> TRAM_LAG1_CLN8  TLC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  121.7  28.6   1.8e-39   3.2e-35       3     198 .]     184     409 ..     182     409 .. 0.90

  Alignments for each domain:
  == domain 1  score: 121.7 bits;  conditional E-value: 1.8e-39
  TRAM_LAG1_CLN8   3 dervvslvqyllstvfglivlsssp......elwegy.perilgathfllkayyllalgYfiydllvlllyekkrkdfvemliHhiitlvllvls 90 
                      e+++ +++y+ s v+g+ +l+++p      +l  gy +e++ ++ +  +++y+l+++g++++ l+ ll+++++ kdfveml+Hh++t+vl+v++
      EFC38033.1 184 MENLWFSLYYIASAVLGFLILKETPwfwdlsHLVIGYpQEQTGYEISPFVRMYLLVGAGFYFQALFTLLFVDERMKDFVEMLVHHLVTIVLIVWC 278
                     6899*********************666555444455544444555677888******************************************* PP

  TRAM_LAG1_CLN8  91 yvrnlgrvglvvlllhelsdpflnlrkilsylkkkskssklvlfngllfllsFfvcRlvllpylillsildvaklslstap.............. 171
                     ++++++r+g++vlllh+++d+fl+ +k+l+   k+ ++++ +lf  + f++sF+++Rlv+lpyli+ + ++v +  +++ p              
      EFC38033.1 279 VISYYHRIGTLVLLLHDVVDVFLYSAKTLKLF-KQ-EKICEMLF--VGFVVSFLILRLVYLPYLIINALFFVTN--SWDYPqryyifryvenans 367
                     ********************************.66.688*****..********************99999987..56555679*********** PP

  TRAM_LAG1_CLN8 172 ...............lwlpliflilllvLqllnlyWfylivk 198
                                    + +++ ++ ll+vL +l+++Wf++i+k
      EFC38033.1 368 llevtnyggclfkycISSFWSLISLLVVLVSLHIFWFSMIMK 409
                     **************999999********************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (428 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1180  (0.0658152); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.44
# Mc/sec: 2952.50
//
Query:       EFC38034.1  [L=985]
Description: Hypothetical protein NAEGRDRAFT_74284 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00022   21.0   0.9     0.0046   16.8   0.2    3.0  2  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.011   15.7   0.1      0.011   15.7   0.1    3.7  3  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.2   5.1e-07    0.0046       6      37 ..     207     239 ..     202     243 .. 0.84
   2 ?    1.0   0.0     0.044   3.9e+02       3      17 ..     589     603 ..     588     612 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 5.1e-07
  F-box-like   6 dEiLlqIFsyLppsdLlrl.alVCrrWrrvald 37 
                 +EiL++I++yL+++dL  + +  C+++++ +  
  EFC38034.1 207 PEILSYILQYLDTYDLFTCaRPICKKFKQSVDQ 239
                 8*****************8468****9998855 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.044
  F-box-like   3 rLPdEiLlqIFsyLp 17 
                  LP  +Ll ++s  p
  EFC38034.1 589 FLPSSVLLSVLSNCP 603
                 59*********9754 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.7   0.1   1.2e-06     0.011       3      41 ..     202     241 ..     201     246 .. 0.84
   2 ?    0.7   0.7     0.058   5.2e+02       6      25 ..     590     609 ..     589     611 .. 0.87
   3 ?   -2.7   0.1      0.69   6.2e+03      30      46 ..     811     827 ..     810     828 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.2e-06
                 HHHS-HHHHHHHHHTS-HHHHHHHCT.T-HHHHHHHTTHH CS
       F-box   3 lsrLPsevlrhILerLplsdllalrr.VSkgwrilidsdr 41 
                 + +L +e+l  IL++L++ dl+ ++r  +k++++ +d d+
  EFC38034.1 202 ICDLAPEILSYILQYLDTYDLFTCARpICKKFKQSVDQDS 241
                 78999***************99999878888888888776 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.058
                 S-HHHHHHHHHTS-HHHHHH CS
       F-box   6 LPsevlrhILerLplsdlla 25 
                 LPs vl+ +L+++p ++ l 
  EFC38034.1 590 LPSSVLLSVLSNCPNVEHLV 609
                 9************9988765 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 0.69
                 -HHHHHHHTTHHHHHHH CS
       F-box  30 Skgwrilidsdrlwcks 46 
                 S++ +++++++ ++ ++
  EFC38034.1 811 SRNSNSFLRNIYFYSWK 827
                 899999******99996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (985 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       821  (0.0457917); expected 358.6 (0.02)
Passed bias filter:                      301  (0.0167884); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.29s 00:00:01.04 Elapsed: 00:00:00.50
# Mc/sec: 5951.34
//
Query:       EFC38035.1  [L=503]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-10   40.8   0.0    7.4e-10   39.0   0.0    1.9  2  BTB       BTB/POZ domain
  ------ inclusion threshold ------
      0.023   14.8   0.3       0.15   12.2   0.2    2.2  2  BACK      BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.0   8.3e-14   7.4e-10       7     100 ..      20     108 ..      14     118 .. 0.84
   2 ?   -0.3   0.0      0.14   1.2e+03      60     107 ..     104     152 ..     101     155 .. 0.77

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 8.3e-14
                 HTTTS-EEEEETT...TEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHH CS
         BTB   7 sgelcDvtlvvgd...gkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlk 100
                 s+++ D  ++v     g+ fk h++vLa+    Fk+lf+s      s  +i++++ +p++++++L f Y+g+++ +  +++  lL++ + +  p+++
  EFC38035.1  20 SESYPDGEIRVTFngtGEVFKIHRIVLACKNMSFKQLFSSS-----S--MITITKHKPSIVRKFLTFYYSGRIDWE-NNEIIPLLQLSNEYFAPEIV 108
                 55677766666655569***********************9.....3..7999**********************7.9**********888777665 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.14
                 GHHHHHHHHHHHHHSEEEC-.CGGGHHHHHHHHHHHT-HHHHHHHHHHH CS
         BTB  60 epeafealLefiYtgeleit.seenleelLaaadllqiprlkkaceefl 107
                  pe++ +lL+ ++   ++i   ++  e++L++ ++++  +  + c++ +
  EFC38035.1 104 APEIVVSLLHNLHDNFTSIIqGDNIFEDVLKLLSIFNETKTSNYCKNTF 152
                 5788888888888888877744455689999999999999999998765 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.16   1.4e+03       4      38 ..      95     129 ..      92     138 .. 0.81
   2 ?   12.2   0.2   1.6e-05      0.15      14      85 ..     214     288 ..     210     298 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.16
        BACK   4 ilefAeaysceeLaeaakefilknfeevlkseeFl 38 
                 +l++++ y   e+  +  + +++nf+++++ ++ +
  EFC38035.1  95 LLQLSNEYFAPEIVVSLLHNLHDNFTSIIQGDNIF 129
                 56788888888999999999999999999998865 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 1.6e-05
        BACK  14 eeLaeaakefilknfeevlkseeFle.Lskeqllellss.deL.nvesEeevfeavlkWvkhdeeerkkhlpelL 85 
                 ++++ ++ e ++ nfe+++k++ Fl+ ++ e+++ ++ + +eL n+    + + a+l+W++hd ++r k  + l+
  EFC38035.1 214 KSIKVKCLECLQGNFEKFIKNQVFLSiVNIEDVKRIIMElSELnNFGGRGQFLPALLNWINHDYQNRFKDSSLLF 288
                 788999********************7799***999853366625778889999***********9998877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.27s 00:00:00.91 Elapsed: 00:00:00.48
# Mc/sec: 3164.50
//
Query:       EFC38036.1  [L=243]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.4e-34  117.1   0.2    5.4e-34  117.1   0.2    2.1  2  Ribosomal_L6e  Ribosomal protein L6e


Domain annotation for each model (and alignments):
>> Ribosomal_L6e  Ribosomal protein L6e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.6     0.031   5.5e+02      56     100 ..      32      79 ..       5      91 .. 0.65
   2 !  117.1   0.2     3e-38   5.4e-34       1     111 []     136     243 .]     136     243 .] 0.95

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.031
  Ribosomal_L6e  56 feekkekkelseerkadqkavDkallaaikke...kllkkYLkskFsL 100
                    f +k + + ++++ k ++k v ++ ++ ++++   ++  + +++ FsL
     EFC38036.1  32 FWKKGTFSYIKSDAKRTKKVVKQQKIKVVRNKatvEVADDRIAADFSL 79 
                    444444455666666667777777666666654445555555555555 PP

  == domain 2  score: 117.1 bits;  conditional E-value: 3e-38
  Ribosomal_L6e   1 lNgvPLrRvnqryVIatstkvdlsgvdekipeklndeyFkkekkkkkkkkkeeelfeekkekkelseerkadqkavDkallaaikkekllkkYLks 96 
                    lNgvPLrRvnqryVIatstkvd+s v  ++p++++d++F+ke+k++ +++ +++ f +  +k ++see+k++ +avD++++aa+ k++llk+YL++
     EFC38036.1 136 LNGVPLRRVNQRYVIATSTKVDVSAV--TVPATVTDATFTKEHKTRLDETGKKSWFRAG-KKGAISEENKKTFDAVDQQVVAAVGKVELLKEYLQT 228
                    7*************************..**************99988888888899776.5669******************************** PP

  Ribosomal_L6e  97 kFsLrkgdyphelkF 111
                     F L++gd+phe+kF
     EFC38036.1 229 PFRLQNGDKPHEMKF 243
                    **************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       876  (0.0488594); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 1844.22
//
Query:       EFC38037.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2107  (0.117519); expected 358.6 (0.02)
Passed bias filter:                      632  (0.0352502); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.77u 0.39s 00:00:01.16 Elapsed: 00:00:00.51
# Mc/sec: 1256.98
//
Query:       EFC38038.1  [L=647]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.58    9.5   2.8        7.6    5.8   0.1    2.8  3  ZnuA          Zinc-uptake complex component A periplasmic
       0.61   10.1  11.7        3.7    7.6   2.2    3.5  3  DUF1043       Protein of unknown function (DUF1043)
        3.4    8.1   7.0       0.85   10.1   0.6    3.2  3  H-kinase_dim  Signal transducing histidine kinase, homodimeri


Domain annotation for each model (and alignments):
>> ZnuA  Zinc-uptake complex component A periplasmic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.1    0.0013       7.6     119     150 ..     217     248 ..     211     254 .. 0.87
   2 ?    3.2   0.1    0.0081        48     116     182 ..     252     322 ..     243     370 .. 0.78
   3 ?   -2.6   0.0       0.5     3e+03     127     150 ..     524     547 ..     521     554 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0013
                 GGHHHHHHHHHHHHHHHHHHHHHHHHHHTTSS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ZnuA 119 anadtyeanaaayiekLeeldaeireelaeip 150
                 a +d+++an+++++ekL+ l++ei++  +e++
  EFC38038.1 217 ASKDQLTANLERFTEKLKSLNDEIASIHQEMK 248
                 57899*******************98877665 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.0081
                 HTGGGHHHHHHHHHHH.HHHHHHHHHHHHHHHTTSSGTEGEEEESSSTTHHHH...HHTT-EEEEEE..SSSS CS
                 xxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxx..xxxx RF
        ZnuA 116 adpanadtyeanaaay.iekLeeldaeireelaeipeekrklvtthdafgyla...rayglevagia..gist 182
                 +d + + ++++n +++  +kLe+++++  ++ +ei   +  ++ +++ f yl+   +++g++v g +  +i++
  EFC38038.1 252 VDLQSKFELKQNVDTFaSKKLETVQKKRIQKRKEITDME--FFLDNHLFLYLEkshKEFGIDVFGWIipTIYK 322
                 56667778899999994579*****99999999999777..***********977778899888765555554 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 0.5
                 HHHHHHHHHHHHHHHHHHHHTTSS CS
                 xxxxxxxxxxxxxxxxxxxxxxxx RF
        ZnuA 127 naaayiekLeeldaeireelaeip 150
                 n  ++iekL + d+e+ e +++ +
  EFC38038.1 524 NIWSFIEKLAKNDEELSEIVKTTN 547
                 566799999999999999999766 PP

>> DUF1043  Protein of unknown function (DUF1043)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   2.2   0.00062       3.7      44     103 ..     219     281 ..     212     292 .. 0.76
   2 ?    5.1   1.2    0.0037        22      26     118 ..     337     439 ..     324     442 .. 0.75
   3 ?    0.6   0.0     0.089   5.3e+02      31      63 ..     530     562 ..     514     565 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00062
     DUF1043  44 kqeledHfaqsaelLetlaedyqkLyqhlaksseeL...lpeleeqelfqqkkleekkaeaee 103
                 k++l+  +++  e L++l+++   ++q +++ s  L   +  +++ ++f +kkle+ ++++ +
  EFC38038.1 219 KDQLTANLERFTEKLKSLNDEIASIHQEMKSISVDLqskFELKQNVDTFASKKLETVQKKRIQ 281
                 899999******************************775223344455666666665554433 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0037
     DUF1043  26 qkklekelekakaeleeqkqeledHfaqsa.elLetlaedyqkLyqhlaksseeL.....lpeleeqelfqqkkleekkaeaee.....eeeeeqPrDY 113
                 q + ++e   +k  ++++ + l ++++ ++ e+L++  e y+ ++q l++s+ ++     l   +eq+  ++k+++++++++++     +++  +P D+
  EFC38038.1 337 QYEQKHEPSITKYIINRNMNGLLEYLEDNKfEILDNDLEVYRSIHQELSSSTPNFlylatL-FTDEQKKGYSKEISQAQRAEKArilntRPSVVTPEDF 434
                 555666666778888888889999998654399**999************99998787643.4566666666777777766665678777777788888 PP

     DUF1043 114 segas 118
                  e+++
  EFC38038.1 435 EEEEE 439
                 88776 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.089
     DUF1043  31 kelekakaeleeqkqeledHfaqsaelLetlae 63 
                 ++l k+ +el+e  +  ++Hf +  + L+++a 
  EFC38038.1 530 EKLAKNDEELSEIVKTTNTHFRRRTTRLSSIAP 562
                 578889999999999999999999988888875 PP

>> H-kinase_dim  Signal transducing histidine kinase, homodimeric domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.87   5.2e+03      22      37 ..      82      98 ..      78     147 .. 0.65
   2 ?   10.1   0.6   0.00014      0.85      24      65 ..     218     257 ..     215     259 .. 0.90
   3 ?   -0.5   0.1      0.28   1.7e+03      38      58 ..     540     560 ..     468     563 .. 0.54

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.87
  H-kinase_dim 22 VitkarLnqsleefr.f 37
                  + ++++L q+++e + +
    EFC38038.1 82 IYARTKLVQLTSEKQvI 98
                  66677777777766641 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00014
  H-kinase_dim  24 tkarLnqsleefrfenglkasvtelksslqnlgrisgeLQeg 65 
                   +k +L+  le+f   ++lk++++e++s  q+++ is +LQ++
    EFC38038.1 218 SKDQLTANLERFT--EKLKSLNDEIASIHQEMKSISVDLQSK 257
                   6788899999999..8899*********************86 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.28
  H-kinase_dim  38 englkasvtelksslqnlgri 58 
                    +  k+++t +++ +++l+ i
    EFC38038.1 540 SEIVKTTNTHFRRRTTRLSSI 560
                   244566666666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (647 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1827  (0.101902); expected 358.6 (0.02)
Passed bias filter:                      643  (0.0358637); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.28s 00:00:01.03 Elapsed: 00:00:00.47
# Mc/sec: 4098.65
//
Query:       EFC38039.1  [L=270]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.01   15.7   0.0        8.8    6.1   0.0    3.0  3  DUF3841   Domain of unknown function (DUF3841)
      0.053   13.5   0.0       0.27   11.2   0.0    1.9  2  DUF1007   Protein of unknown function (DUF1007)


Domain annotation for each model (and alignments):
>> DUF3841  Domain of unknown function (DUF3841)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.34     3e+03      85     118 ..      29      63 ..      15      82 .. 0.68
   2 ?    6.0   0.0     0.001       9.3      59     109 ..     102     152 ..      89     204 .. 0.81
   3 ?    6.1   0.0   0.00098       8.8      38      68 ..     224     254 ..     200     262 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.34
     DUF3841  85 evpkeevllsdfdkWnki.LnesYipedeedekaf 118
                 ev+++     d  ++ ++ L e+Y  +  + e+ +
  EFC38039.1  29 EVNPNTTSAYDGFDYSQLmLRENYSEQKANSEALY 63 
                 55555555555555544448888877776666655 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.001
     DUF3841  59 veypiWvwvrekallrksektvileLevpkeevllsdfdkWnkiLnesYip 109
                  + p+W++++++++ + +   + ++++  ke+v l+d +    +Ln s++ 
  EFC38039.1 102 ENKPVWISISQEKVSNSGGFLFEYKIDTLKEKVELFDNAHTLDVLNTSFYI 152
                 5679*****999999888888888999999*******99999999998764 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.00098
     DUF3841  38 fleaYdWlvkeakkrvkkpeeveypiWvwvr 68 
                    +Y  +vk+ ++ +   ++v++ iW++v+
  EFC38039.1 224 EPGSYFCMVKKNDTNISLGNDVDFSIWCSVH 254
                 4458999*********************984 PP

>> DUF1007  Protein of unknown function (DUF1007)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0     3e-05      0.27      53     168 ..      62     174 ..      57     187 .. 0.74
   2 ?   -0.3   0.0       0.1   9.1e+02      79     101 ..     222     244 ..     210     259 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 3e-05
     DUF1007  53 lqgldknkdgvldeeelaelakenvenlk.eyeYFtelkaggkklkfaepeeeysleyqdgrltlsFtl.plkepvkakkkkltlevyDptyYvafeya 149
                 l+++   +dg ++ + +ae     + n+  +y+YF++ ++++k++ ++  +e++s   + g   +++ +  lke+v++  +  tl+v   ++Y+ + ++
  EFC38039.1  62 LYDFPMLGDGSYKIKLIAEGSSLGIRNVTfSYGYFQFEQSENKPVWISISQEKVS---NSGGFLFEYKIdTLKEKVELFDNAHTLDVLNTSFYIRVVVE 157
                 56666666666665555555555555554269***************99977665...4577788888878************************9998 PP

     DUF1007 150 edeavtlagapagCsvevv 168
                   e+ +     + C++e++
  EFC38039.1 158 CSEKSSY--DIEICQKETI 174
                 6444333..3467777665 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.1
     DUF1007  79 nlkeyeYFtelkaggkklkfaep 101
                 nl+  +YF  +k++++++++++ 
  EFC38039.1 222 NLEPGSYFCMVKKNDTNISLGND 244
                 78888999999999999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       449  (0.0250432); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.54
# Mc/sec: 1510.10
//
Query:       EFC38040.1  [L=569]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.4e-25   88.0  11.6      1e-17   64.3   1.6    3.3  3  CH               Calponin homology (CH) domain
    4.8e-06   25.5  27.2    4.8e-06   25.5  27.2    2.2  3  AAA_13           AAA domain
  ------ inclusion threshold ------
      0.048   13.5   0.0        7.1    6.5   0.0    2.9  2  CAMSAP_CH        CAMSAP CH domain
      0.093   13.3   1.7       0.37   11.4   1.7    2.1  1  RPA_interact_C   Replication protein A interacting C-terminal
        1.5    8.0  33.6       0.72    9.1  17.8    2.4  2  DUF3450          Protein of unknown function (DUF3450)
        2.4    7.2   5.4        5.3    6.0   5.4    1.5  1  ABC2_membrane_3  ABC-2 family transporter protein
        2.6    8.4   9.4       0.81   10.0   0.5    2.8  2  DUF4510          Domain of unknown function (DUF4510)
          3    6.9   6.0       0.53    9.4   0.9    2.4  4  AI-2E_transport  AI-2E family transporter
        3.2    5.1  35.4        8.4    3.8  35.4    1.6  1  DUF3584          Protein of unknown function (DUF3584)
        9.9    6.6  44.6       0.28   11.6  35.4    2.5  2  Fez1             Fez1


Domain annotation for each model (and alignments):
>> CH  Calponin homology (CH) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.3   1.6   5.6e-21     1e-17       3     108 ..      32     152 ..      30     153 .. 0.92
   2 !   29.6   0.0   3.3e-10   5.9e-07       3     106 ..     174     291 ..     172     294 .. 0.83
   3 ?   -1.9   0.9         2   3.7e+03      52      68 ..     401     417 ..     353     449 .. 0.58

  Alignments for each domain:
  == domain 1  score: 64.3 bits;  conditional E-value: 5.6e-21
                 HHHHHHHHHHHHHTTSTTSSTTSCHHHHHTTSHHHHHHHHHHSTTTSSGGGSTTT..................HHHHHHHHHHHHHHHHHHTTCHTTSS CS
          CH   3 qkkellrWinshleeagpkvkvedfeedlrDGvlLckLlnklapglvdkkklnks..................efkkleNinlaldvaekklgvpkvli 83 
                 q  ++++W+n +l++  ++++ved+++++ DGv Lc Ll++l+ +   kkk +k+                  + +++eNinlal++++ + g++++ i
  EFC38040.1  32 QHVTFTQWVNVQLRK--ENITVEDLTSAFVDGVNLCYLLDQLKSKVKTKKKKKKQnsisettlsskmnkkpkiPIQMIENINLALNSMA-QSGINLTGI 127
                 5679*********77..79999********************888877777766688999999999********************999.********* PP

                 -HHHHHTTSHHHHHHHHHHHHHHHH CS
          CH  84 eaedlvegknksvltllaqLfrafq 108
                 +++++ +g+ k +l+l++ +++ +q
  EFC38040.1 128 TSDEIHKGNLKICLALVWRMILFYQ 152
                 ********************99887 PP

  == domain 2  score: 29.6 bits;  conditional E-value: 3.3e-10
                 HHHHHHHHHHHHHTTSTTSSTT..SCHHHHHTTSHHHHHHHHHHSTTTSSGGGSTTT............HHHHHHHHHHHHHHHHHHTTCHTTSS-HHH CS
          CH   3 qkkellrWinshleeagpkvkv..edfeedlrDGvlLckLlnklapglvdkkklnks............efkkleNinlaldvaekklgvpkvlieaed 87 
                  +k +l+W+++ + e+++k      d +++++DG +L ++++kl  ++++ + +++                k e  +  ++va+++l +p +  +++ 
  EFC38040.1 174 VEKSMLNWVQDIISEYTEKYGFsvGDISSSWSDGKALGAVIDKLMKEKFRNDLEEMFkyfnyerdvintTKSKSEINEHLVSVANDQLEIPNLI-DSDI 271
                 6899***********998876566********************777766665544467777788999888888888889999*********99.8888 PP

                 HHTTSHH.HHHHHHHHHHHH CS
          CH  88 lvegknk.svltllaqLfra 106
                 l +g +k s+lt+l+ + ++
  EFC38040.1 272 LEKGPEKlSMLTYLSYFKEK 291
                 88888888******999876 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2
                 GGSTTTHHHHHHHHHHH CS
          CH  52 kklnksefkkleNinla 68 
                  +++++ ++ +e+++  
  EFC38040.1 401 IEEKQKVVQEVEKLTEE 417
                 33333333333333333 PP

>> AAA_13  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.3      0.28     5e+02     133     153 ..      71      91 ..      41     126 .. 0.55
   2 ?   -2.1   0.1      0.62   1.1e+03     441     462 ..     216     248 ..     156     266 .. 0.48
   3 !   25.5  27.2   2.7e-09   4.8e-06     252     470 ..     343     558 ..     339     568 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.28
      AAA_13 133 ledeawkkivkkknsalseal 153
                 l++++++k++kkk++ +se+ 
  EFC38040.1  71 LKSKVKTKKKKKKQNSISETT 91 
                 222222222222222222221 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.62
      AAA_13 441 kleee...........ikeLekqlrdekpaaee 462
                 kl +e             + e+ + + +++ +e
  EFC38040.1 216 KLMKEkfrndleemfkYFNYERDVINTTKSKSE 248
                 333332222222222122222333333333333 PP

  == domain 3  score: 25.5 bits;  conditional E-value: 2.7e-09
      AAA_13 252 eassdtCpFCgq.plpaerkaaLeahFddefeekqerLekliekveskkselleklkavsdeasensafeedkeelkaeaealeeqLkglqralea.Kr 348
                 +++ +tCpFC + +++ e+k a  +  + + +ek+++Le   +++++ k++  +kl+++++e+++     +++e+l++e+++ ++qL++ ++++e+ + 
  EFC38040.1 343 HDE-KTCPFCSNlNIQLELKLAECSKLEIDINEKKQQLEAVEQSLNEVKENSEQKLTTLIEEKQK---VVQEVEKLTEELSQATNQLEKEKEEIEKiRE 437
                 344.7*****99888888888888889999999****************9***********7765...7899999999**********99999987344 PP

      AAA_13 349 kepfksvelesvkakiesikklvaeineliakhNekvanleeekeeakkklelhlveele...seldeykkkykklekaieklekelkeeeaelkklee 444
                 +e + + +lesvk+++   +++v+++ + +++ N    +l+e+ e  +k+ e+ l +++e   ++++ y++k+k+++   e++e+++ +  ++ + +ee
  EFC38040.1 438 TEQSLKNNLESVKSELIISNNSVDDLRREVERLNSVELELKEKLEIERKEKEA-LKQNFEksiEKINSYEEKLKSFQ---EQVENSIVAVDEQSESKEE 532
                 55666888********999*********************9998876665554.33344400055667777777777...77778888899999999** PP

      AAA_13 445 eikeLekqlrdekpaaeeinkeLkaf 470
                 e + +e++ r+++++++++  +  a+
  EFC38040.1 533 ELNPIETTPRNQREPVANMVYYFFAV 558
                 ****************9987666555 PP

>> CAMSAP_CH  CAMSAP CH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0    0.0039       7.1      12      32 ..      50      70 ..      40      77 .. 0.87
   2 ?    3.5   0.0     0.036        65      12      31 ..     196     215 ..     188     224 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0039
   CAMSAP_CH 12 pvedllrdlsdGvaLaalihf 32
                 vedl+  + dGv L+ l+  
  EFC38040.1 50 TVEDLTSAFVDGVNLCYLLDQ 70
                69****************975 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.036
   CAMSAP_CH  12 pvedllrdlsdGvaLaalih 31 
                 +v d+  ++sdG aL a+i 
  EFC38040.1 196 SVGDISSSWSDGKALGAVID 215
                 688999***********996 PP

>> RPA_interact_C  Replication protein A interacting C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   1.7    0.0002      0.37       1      48 [.     347     393 ..     347     425 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.0002
  RPA_interact_C   1 lCPvCkkrklketsevifCeCglrletseesltleelkrrlaetveeH 48 
                     +CP C++ +++ + ++  C+ +l+++ +e++ +le ++++l+e+ e+ 
      EFC38040.1 347 TCPFCSNLNIQLELKLAECS-KLEIDINEKKQQLEAVEQSLNEVKENS 393
                     5**********999988776.58888888999*********9987665 PP

>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1  17.8    0.0004      0.72      16      92 ..     374     450 ..     362     453 .. 0.91
   2 ?    4.0   8.3     0.014        26      16      97 ..     458     543 ..     450     553 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0004
     DUF3450  16 atldqalkeaekavaaaaqsqkkidklddekqellaeyralkeeleslevyneqlerlvasqeqeiasleeqieeie 92 
                 ++ +q+++++++ ++ ++ s++k + l +ekq++++e+++l+eel++++ + e+ ++ +++ +++ +sl++++e+++
  EFC38040.1 374 EKKQQLEAVEQSLNEVKENSEQKLTTLIEEKQKVVQEVEKLTEELSQATNQLEKEKEEIEKIRETEQSLKNNLESVK 450
                 667899999999**********************************************************9999986 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.014
     DUF3450  16 atldqalkeaekavaaaaqsqkkidklddekqella....eyralkeeleslevyneqlerlvasqeqeiasleeqieeieeiere 97 
                 +++d+++ e e+ ++ + +  +k +   +ek+ l++     ++++++  e+l+ ++eq+e+++ +++++ +s ee+++ ie + r+
  EFC38040.1 458 NSVDDLRREVERLNSVELELKEKLEIERKEKEALKQnfekSIEKINSYEEKLKSFQEQVENSIVAVDEQSESKEEELNPIETTPRN 543
                 55666666666666666666666655555555554400005677888888899999999999999999999999999999988665 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   5.4     0.003       5.3      41     171 ..     405     563 ..     373     565 .. 0.57

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.003
  ABC2_membrane_3  41 n.........sslsqqlvealea.spsvelvyevdseeeakkalkngdidgilvipkgfskdll....................kgesatvtvl 104
                      +         ++  +q +++le+  +++e  +  ++e+++k+ l++ + + i+   ++  +dl                      +e   ++  
       EFC38040.1 405 QkvvqeveklTEELSQATNQLEKeKEEIE--KIRETEQSLKNNLESVKSELII--SNNSVDDLRreverlnsvelelkekleieRKEKEALKQN 494
                      24433332221111222233333222333..5556677777777777777555..333333344778888888888888887773333333333 PP

  ABC2_membrane_3 105 inssnlnsskailnalnsllqqlnasalv...lqseatstsaninvestqleeelsnvasflvgliliil 171
                      +++s   ++++ ++ l+s+++q  +s+ +   ++++++++  +i+++ ++  e+  n+++++++++ + +
       EFC38040.1 495 FEKSIE-KINSYEEKLKSFQEQVENSIVAvdeQSESKEEELNPIETTPRNQREPVANMVYYFFAVLGVSF 563
                      333332.23455555555555555555446655566788889999999999**********999877665 PP

>> DUF4510  Domain of unknown function (DUF4510)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   2.9      0.27   4.9e+02      20      42 ..     402     424 ..     376     453 .. 0.73
   2 ?   10.0   0.5   0.00045      0.81      14      88 ..     455     533 ..     447     549 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.27
     DUF4510  20 gelelvareLqalqeeLqeaaea 42 
                 +e ++v++e+++l eeL +a+++
  EFC38040.1 402 EEKQKVVQEVEKLTEELSQATNQ 424
                 56778888888888888877654 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00045
     DUF4510  14 ipesGagelelvareLqalqeeLqeaaeaRRaawearvgglgqGpewsaarr....alqeaVaqeLaaLqlsweqdeap 88 
                 i+++  ++l++ +  L+++++eL+e++e  R ++ea  ++ ++  e+ ++        qe V++ + a+ +  e  e+ 
  EFC38040.1 455 ISNNSVDDLRREVERLNSVELELKEKLEIERKEKEALKQNFEKSIEKINSYEeklkSFQEQVENSIVAVDEQSESKEEE 533
                 566778999****************************988777766554433223378888888888887665555544 PP

>> AI-2E_transport  AI-2E family transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       2.1   3.8e+03      31      51 ..      64      85 ..      52     123 .. 0.53
   2 ?   -3.3   0.0       2.2   3.9e+03     160     189 ..     206     235 ..     205     243 .. 0.80
   3 ?    9.4   0.9    0.0003      0.53      75     130 ..     400     454 ..     396     467 .. 0.88
   4 ?   -2.7   0.0       1.4   2.5e+03      79     138 ..     502     557 ..     486     564 .. 0.48

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.1
  AI-2E_transport 31 layllnpvvkfL.kkrgvkrvl 51
                     l+yll +++ +  +k++ k+  
       EFC38040.1 64 LCYLLDQLKSKVkTKKKKKKQN 85
                     5555555555553333333333 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.2
  AI-2E_transport 160 dgeklrqgilkllpervrervkailrelek 189
                      dg+ l   i kl+ e+ r++++++++  + 
       EFC38040.1 206 DGKALGAVIDKLMKEKFRNDLEEMFKYFNY 235
                      677788889999999999999999998876 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.0003
  AI-2E_transport  75 liaqltqlvkslpayidslqnilnelpslleelenliqalkqslskilsnilssil 130
                      li+  +++v+++++++++l++ +n+l+++ ee e  i++ +qsl ++l+++ s+++
       EFC38040.1 400 LIEEKQKVVQEVEKLTEELSQATNQLEKEKEEIE-KIRETEQSLKNNLESVKSELI 454
                      567779999******************9999998.8***************99985 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 1.4
  AI-2E_transport  79 ltqlvkslpayidslqnilnelpslleelenliqalkqslskilsnilssilnsllslla 138
                      +++  ++l+ ++++++n++  +++  e +e    +  + ++++ +n ++ ++n++++++a
       EFC38040.1 502 INSYEEKLKSFQEQVENSIVAVDEQSESKE----EELNPIETTPRNQREPVANMVYYFFA 557
                      333333444444444444444444444442....33344444455555555555555554 PP

>> DUF3584  Protein of unknown function (DUF3584)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8  35.4    0.0047       8.4     265     428 ..     366     531 ..     351     550 .. 0.69

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.0047
     DUF3584 265 sllkgel...kadeerlaekqeevqeakaelkqqlrtledelkeaidelnqelsaakaklaakeselealeeqkkkyedadieklkadldqlpsirsel 360
                 s l+ ++   k++ e+++++++ev+e+++++ + l ++++++ +++++l++els+a ++l++ ++e+e++ e ++  +++++e++k +l    +  ++l
  EFC38040.1 366 SKLEIDInekKQQLEAVEQSLNEVKENSEQKLTTLIEEKQKVVQEVEKLTEELSQATNQLEKEKEEIEKIRETEQS-LKNNLESVKSELIISNNSVDDL 463
                 445555500045555566677777777777777778889999999*************************987665.78999*9999997777777777 PP

     DUF3584 361 eeleeeldaltekhqdvqekydrrkqkikeeleeeleklkerleaireekdrlkaaieealealesql 428
                 +   e+l+ ++ + ++  e   ++k ++k+++e+ +ek+++ +e+++  ++++ + i ++ e+ es+ 
  EFC38040.1 464 RREVERLNSVELELKEKLEIERKEKEALKQNFEKSIEKINSYEEKLKSFQEQVENSIVAVDEQSESKE 531
                 77667777666555443334456677888889999999888877777777776555554444444433 PP

>> Fez1  Fez1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   1.7      0.75   1.3e+03     128     170 ..     205     245 ..      43     247 .. 0.49
   2 ?   11.6  35.4   0.00016      0.28      27     197 ..     359     534 ..     353     535 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.75
        Fez1 128 eeleelkreverlraeLkeerqkkeeqassFeqERrtWqeeKe 170
                 ++ ++l + +++l +e  + r+  ee+ + F+ ER + ++ K+
  EFC38040.1 205 SDGKALGAVIDKLMKE--KFRNDLEEMFKYFNYERDVINTTKS 245
                 3333333333333332..2345556777777777777666665 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00016
        Fez1  27 tqklseivalkaqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelselsleeeeaalesdeakaq.r 124
                   kl e  +l  ++ e +++le+ e++++e++e++e+k +    + +e q+  +e+e l e+++++ ++l++ +ee+++  ++e++ +++ +++k +  
  EFC38040.1 359 ELKLAECSKLEIDINEKKQQLEAVEQSLNEVKENSEQKLTT---LIEEKQKVVQEVEKLTEELSQATNQLEKEKEEIEKIRETEQSLKNNLESVKSElI 454
                 56888999999999999999999999999999999888665...4445555555666666666666666666666666666555555556666665523 PP

        Fez1 125 qeaeeleelkreverlra.......eLkeerqkkeeqassFeqERrtWqeeKekVirYqkqLQlnYvqmyrrnqaLEkel 197
                  +++++++l+reverl++       +L+ er++ke+ +++Fe+  ++ ++  ek   +q q   + v +  ++++ E+el
  EFC38040.1 455 ISNNSVDDLRREVERLNSvelelkeKLEIERKEKEALKQNFEKSIEKINSYEEKLKSFQEQVENSIVAVDEQSESKEEEL 534
                 45788999999999999999988889*****************9999999999999*****9999998877777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (569 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3799  (0.211891); expected 358.6 (0.02)
Passed bias filter:                      800  (0.0446204); expected 358.6 (0.02)
Passed Vit filter:                       223  (0.0124379); expected 17.9 (0.001)
Passed Fwd filter:                        96  (0.00535445); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.60u 0.40s 00:00:02.00 Elapsed: 00:00:00.63
# Mc/sec: 2726.91
//
Query:       EFC38041.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.056   13.0   3.4        0.1   12.2   3.4    1.4  1  Baculo_11_kDa  Baculovirus 11 kDa family


Domain annotation for each model (and alignments):
>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   3.4   5.8e-06       0.1      39      64 ..     239     264 ..     232     269 .] 0.79

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.8e-06
  Baculo_11_kDa  39 vicglvvfvvivlfilLlvvilknae 64 
                    v+c++ + +++v+ i+L++  +++++
     EFC38041.1 239 VVCCFCIWIIVVVVIVLILRKASKQN 264
                    9****************987555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       873  (0.0486921); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1654.63
//
Query:       EFC38042.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-36  119.8   1.2    0.00028   20.7   0.0    7.1  7  LRR_6     Leucine Rich repeat
    1.3e-34  117.7   8.1    8.2e-10   38.3   0.2    3.2  4  LRR_8     Leucine rich repeat
    2.6e-21   75.4   0.4    1.4e-05   25.3   0.0    4.2  3  LRR_4     Leucine Rich repeats (2 copies)
    1.7e-14   52.1   0.0        5.5    7.9   0.0    7.1  7  LRR_1     Leucine Rich Repeat
    1.2e-13   50.8   0.0      0.029   14.3   0.0    5.9  6  RHH_3     Ribbon-helix-helix domain
  ------ inclusion threshold ------
      0.017   15.0   2.4        1.9    8.2   0.2    2.6  3  UPF0193   Uncharacterised protein family (UPF0193)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   2.1e-05     0.064       5      19 ..       4      18 ..       2      23 .. 0.88
   2 !    9.1   0.0   0.00048       1.4       5      19 ..      28      42 ..      25      47 .. 0.88
   3 !   20.7   0.0   9.3e-08   0.00028       5      24 .]      52      71 ..      49      71 .. 0.92
   4 !   16.6   0.0   1.9e-06    0.0057       4      19 ..      75      90 ..      72      95 .. 0.87
   5 !   20.3   0.0   1.2e-07   0.00037       5      23 ..     100     118 ..      97     119 .. 0.91
   6 !   15.0   0.0   6.3e-06     0.019       4      24 .]     123     143 ..     120     143 .. 0.91
   7 !   16.5   0.0     2e-06    0.0061       4      23 ..     147     166 ..     144     167 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.1e-05
       LRR_6  5 LteLdLsgNdIgDeG 19
                Lt+Ld+ +N+Ig eG
  EFC38042.1  4 LTSLDIGSNEIGVEG 18
                9***********999 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00048
       LRR_6  5 LteLdLsgNdIgDeG 19
                Lt+Ld+ +N+Ig eG
  EFC38042.1 28 LTSLDIYSNEIGVEG 42
                9***********999 PP

  == domain 3  score: 20.7 bits;  conditional E-value: 9.3e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+ +N+Ig eGa+ ++
  EFC38042.1 52 LTSLDIGHNQIGVEGAKYIS 71
                9***************9885 PP

  == domain 4  score: 16.6 bits;  conditional E-value: 1.9e-06
       LRR_6  4 hLteLdLsgNdIgDeG 19
                +Lt+L++ +N+Ig eG
  EFC38042.1 75 SLTSLNIGHNQIGVEG 90
                8*************99 PP

  == domain 5  score: 20.3 bits;  conditional E-value: 1.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+ +N+Ig eGa+ +
  EFC38042.1 100 LTSLDIGHNQIGVEGAKFI 118
                 9***************987 PP

  == domain 6  score: 15.0 bits;  conditional E-value: 6.3e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L++ +N+Ig eGa+ ++
  EFC38042.1 123 SLTSLNIYSNEIGVEGAKYIS 143
                 8****************9885 PP

  == domain 7  score: 16.5 bits;  conditional E-value: 2e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+L++ +N+Ig eGa+ +
  EFC38042.1 147 QLTSLNIDYNEIGVEGAKFI 166
                 69***************987 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.4   0.0     8e-11   2.4e-07       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   35.2   0.1   2.6e-12   7.7e-09       2      61 .]      27      86 ..      26      86 .. 0.98
   3 !   38.3   0.2   2.7e-13   8.2e-10       2      61 .]      51     110 ..      50     110 .. 0.98
   4 !   35.3   0.1   2.4e-12   7.2e-09       2      61 .]      99     158 ..      98     158 .. 0.98

  Alignments for each domain:
  == domain 1  score: 30.4 bits;  conditional E-value: 8e-11
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsLd+ +N + + + +  + +++L++Ld+ +N++ +   + +s +++L+sLd+ +N++
  EFC38042.1  3 QLTSLDIGSNEIGVEGSKYISEMKQLTSLDIYSNEIGVEGSKYISEMKQLTSLDIGHNQI 62
                7*********************************************************98 PP

  == domain 2  score: 35.2 bits;  conditional E-value: 2.6e-12
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsLd+ +N + + + +  + +++L++Ld+++N++ +  ++ +sg++sL+sL++ +N++
  EFC38042.1 27 QLTSLDIYSNEIGVEGSKYISEMKQLTSLDIGHNQIGVEGAKYISGMKSLTSLNIGHNQI 86
                7*********************************************************98 PP

  == domain 3  score: 38.3 bits;  conditional E-value: 2.7e-13
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+ +N++ + + +  +g+++L++L++++N++ +   + +s +++L+sLd+ +N++
  EFC38042.1  51 QLTSLDIGHNQIGVEGAKYISGMKSLTSLNIGHNQIGVEGSKYISEMKQLTSLDIGHNQI 110
                 7*********************************************************98 PP

  == domain 4  score: 35.3 bits;  conditional E-value: 2.4e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+ +N++ + + ++ +g+++L++L++ +N++ +  ++ +s +++L+sL++++N +
  EFC38042.1  99 QLTSLDIGHNQIGVEGAKFISGMKSLTSLNIYSNEIGVEGAKYISEMNQLTSLNIDYNEI 158
                 7*********************************************************87 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0     1e-06    0.0031       1      35 [.       2      37 ..       2      44 .. 0.82
   2 !   25.3   0.0   4.7e-09   1.4e-05       1      36 [.      50      86 ..      50      95 .. 0.84
   3 !   24.1   0.3   1.1e-08   3.4e-05       1      35 [.      98     133 ..      98     163 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 1e-06
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35
                ++L++Ld+++N +   ++  ++ +++L++Ld+ +N  
  EFC38042.1  2 KQLTSLDIGSNEIGVEGSkyISEMKQLTSLDIYSN-E 37
                58************777776445*********777.4 PP

  == domain 2  score: 25.3 bits;  conditional E-value: 4.7e-09
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++Ld+++Nq+   +   ++++++L++L++ +N +i
  EFC38042.1 50 KQLTSLDIGHNQIGVEGAkyISGMKSLTSLNIGHN-QI 86
                58************766686668*********555.87 PP

  == domain 3  score: 24.1 bits;  conditional E-value: 1.1e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 ++L++Ld+++Nq+   +   ++++++L++L++ +N  
  EFC38042.1  98 KQLTSLDIGHNQIGVEGAkfISGMKSLTSLNIYSN-E 133
                 58************766694446*********888.2 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0064        19       1      20 [.       3      22 ..       3      25 .. 0.81
   2 ?    5.0   0.0     0.017        52       1      20 [.      27      46 ..      27      49 .. 0.80
   3 !    7.5   0.0    0.0026       7.8       1      21 [.      51      71 ..      51      73 .. 0.79
   4 !    7.9   0.0    0.0018       5.5       1      20 [.      75      94 ..      75      97 .. 0.82
   5 !    7.1   0.0    0.0035        11       1      17 [.      99     115 ..      99     121 .. 0.76
   6 ?    4.4   0.0     0.026        78       1      18 [.     123     140 ..     123     145 .. 0.77
   7 ?    4.9   0.0     0.018        54       1      17 [.     147     163 ..     147     169 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0064
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++Ld+++n ++  ++ ++
  EFC38042.1  3 QLTSLDIGSNEIGVEGSKYI 22
                599*******9987777666 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.017
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++Ld+ +n ++  ++ ++
  EFC38042.1 27 QLTSLDIYSNEIGVEGSKYI 46
                599*******9987777666 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0026
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++Ld+++n+++  ++ +++
  EFC38042.1 51 QLTSLDIGHNQIGVEGAKYIS 71
                599********9777766665 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0018
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++L++++n+++  ++ ++
  EFC38042.1 75 SLTSLNIGHNQIGVEGSKYI 94
                69*********987777766 PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.0035
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++Ld+++n+++  ++
  EFC38042.1  99 QLTSLDIGHNQIGVEGA 115
                 599********966555 PP

  == domain 6  score: 4.4 bits;  conditional E-value: 0.026
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L++ +n ++  ++ 
  EFC38042.1 123 SLTSLNIYSNEIGVEGAK 140
                 69********99766655 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.018
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++ +n ++  ++
  EFC38042.1 147 QLTSLNIDYNEIGVEGA 163
                 599*******9966555 PP

>> RHH_3  Ribbon-helix-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0   0.00038       1.1      12      35 ..       2      25 ..       1      25 [. 0.92
   2 !   14.3   0.0   9.8e-06     0.029      12      35 ..      26      49 ..      24      49 .. 0.92
   3 ?    4.0   0.0     0.016        48      12      32 ..      50      70 ..      48      71 .. 0.92
   4 !    5.9   0.0    0.0042        13      15      35 ..      77      97 ..      74      97 .. 0.87
   5 ?    0.3   0.0      0.23     7e+02      12      30 ..      98     116 ..      96     118 .. 0.84
   6 !    9.3   0.0   0.00036       1.1      14      35 ..     124     145 ..     122     145 .. 0.90

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00038
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+  S++++++ Sk++ e+
  EFC38042.1  2 KQLTSLDIGSNEIGVEGSKYISEM 25
                68999****************886 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 9.8e-06
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+ +S++++++ Sk++ e+
  EFC38042.1 26 KQLTSLDIYSNEIGVEGSKYISEM 49
                6999*****************886 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.016
       RHH_3 12 elaekLkaLSekTrIprSkll 32
                +++++L+  +++++++ +k++
  EFC38042.1 50 KQLTSLDIGHNQIGVEGAKYI 70
                68999***************8 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.0042
       RHH_3 15 ekLkaLSekTrIprSklldeA 35
                ++L+  +++++++ Sk++ e+
  EFC38042.1 77 TSLNIGHNQIGVEGSKYISEM 97
                6788889***********886 PP

  == domain 5  score: 0.3 bits;  conditional E-value: 0.23
       RHH_3  12 elaekLkaLSekTrIprSk 30 
                 +++++L+  +++++++ +k
  EFC38042.1  98 KQLTSLDIGHNQIGVEGAK 116
                 689999*99******9777 PP

  == domain 6  score: 9.3 bits;  conditional E-value: 0.00036
       RHH_3  14 aekLkaLSekTrIprSklldeA 35 
                 +++L+ +S++++++ +k++ e+
  EFC38042.1 124 LTSLNIYSNEIGVEGAKYISEM 145
                 578****************886 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.2   0.00063       1.9     171     207 ..      18      54 ..      12      61 .. 0.91
   2 ?   -1.1   0.0      0.45   1.3e+03     173     206 ..      68     101 ..      64     109 .. 0.81
   3 ?    5.8   0.0    0.0035        11     171     207 ..     114     150 ..     107     157 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00063
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                   ++++eM++L   + Y+++I  e s+ + e+++l +
  EFC38042.1  18 GSKYISEMKQLTSLDIYSNEIGVEGSKYISEMKQLTS 54 
                 5789*****************************9975 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.45
     UPF0193 173 eFLeeMeaLGqgkkYraiIeteIsqklreleald 206
                 ++++ M++L   +  ++ I  e s+ + e+++l 
  EFC38042.1  68 KYISGMKSLTSLNIGHNQIGVEGSKYISEMKQLT 101
                 6777888888888888999999999999999886 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0035
     UPF0193 171 RkeFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                  ++F++ M++L   + Y+++I  e ++ + e+++l +
  EFC38042.1 114 GAKFISGMKSLTSLNIYSNEIGVEGAKYISEMNQLTS 150
                 579******************************9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       146  (0.00814323); expected 358.6 (0.02)
Passed bias filter:                       94  (0.0052429); expected 358.6 (0.02)
Passed Vit filter:                         9  (0.00050198); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.47u 0.31s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 1127.38
//
Query:       EFC38043.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-27   93.2   0.6    0.00039   20.2   0.0    6.2  6  LRR_6     Leucine Rich repeat
    1.2e-22   79.6  12.3     0.0001   22.6   0.0    3.8  5  LRR_4     Leucine Rich repeats (2 copies)
    1.1e-19   69.9   0.1    1.3e-08   34.4   0.0    2.6  2  LRR_8     Leucine rich repeat
    4.4e-13   47.8   0.0          3    8.8   0.0    6.4  6  LRR_1     Leucine Rich Repeat
    4.2e-11   42.6   0.0      0.018   15.0   0.0    5.1  5  RHH_3     Ribbon-helix-helix domain
  ------ inclusion threshold ------
      0.026   14.0   0.0       0.14   11.6   0.0    1.8  1  LRR_9     Leucine-rich repeat
       0.16   11.8   2.0        2.1    8.1   0.2    2.2  2  UPF0193   Uncharacterised protein family (UPF0193)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   7.5e-07    0.0019       4      19 ..      28      43 ..      25      48 .. 0.86
   2 !   14.2   0.0   1.3e-05     0.034       5      24 .]      53      72 ..      50      72 .. 0.92
   3 !   13.8   0.0   1.8e-05     0.047       5      19 ..      77      91 ..      74      96 .. 0.88
   4 !   10.5   0.0   0.00021      0.54       4      19 ..     100     115 ..      97     120 .. 0.87
   5 !   20.2   0.0   1.5e-07   0.00039       5      24 .]     125     144 ..     122     144 .. 0.92
   6 !    9.1   0.0   0.00055       1.4       5      15 ..     149     159 ..     146     159 .. 0.92

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 7.5e-07
       LRR_6  4 hLteLdLsgNdIgDeG 19
                 Lt+Ld+s+N+Ig eG
  EFC38043.1 28 QLTSLDISDNQIGVEG 43
                69************99 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 1.3e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+ +N+Ig eGa+ ++
  EFC38043.1 53 LTSLDIYYNEIGVEGAKYIS 72
                9***************9885 PP

  == domain 3  score: 13.8 bits;  conditional E-value: 1.8e-05
       LRR_6  5 LteLdLsgNdIgDeG 19
                Lt+Ld+  N+Ig eG
  EFC38043.1 77 LTSLDIGNNQIGVEG 91
                9************99 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 0.00021
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                  Lt+L++ +N+Ig eG
  EFC38043.1 100 QLTSLNIYSNQIGVEG 115
                 69************99 PP

  == domain 5  score: 20.2 bits;  conditional E-value: 1.5e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ +N+Ig eGa+ ++
  EFC38043.1 125 LTSLNIGHNQIGVEGAKYIS 144
                 9***************9885 PP

  == domain 6  score: 9.1 bits;  conditional E-value: 0.00055
       LRR_6   5 LteLdLsgNdI 15 
                 Lt+Ld+ +N+I
  EFC38043.1 149 LTSLDIGHNQI 159
                 9*********8 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.0   5.3e-08   0.00014       2      33 ..      28      61 ..      27      68 .. 0.85
   2 !   21.8   0.0   7.3e-08   0.00019       1      36 [.      51      87 ..      51      94 .. 0.85
   3 !   22.2   0.3   5.4e-08   0.00014       1      36 [.      75     111 ..      75     118 .. 0.83
   4 !   20.2   0.5   2.3e-07   0.00058       2      36 ..     100     135 ..      99     139 .. 0.82
   5 !   22.6   0.0   4.1e-08    0.0001       1      36 [.     123     159 ..     123     160 .] 0.82

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 5.3e-08
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33
                +L++Ld+s+Nq+   ++  ++++++L++Ld+  N
  EFC38043.1 28 QLTSLDISDNQIGVEGSkyISGMKQLTSLDIYYN 61
                69***********777776668*********778 PP

  == domain 2  score: 21.8 bits;  conditional E-value: 7.3e-08
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++Ld+  N +   +   ++ +++L++Ld+ gNn+i
  EFC38043.1 51 KQLTSLDIYYNEIGVEGAkyISEMKQLTSLDI-GNNQI 87
                58************766676445*********.99999 PP

  == domain 3  score: 22.2 bits;  conditional E-value: 5.4e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++Ld++nNq+   ++  ++ + +L++L++ +N +i
  EFC38043.1  75 KQLTSLDIGNNQIGVEGSkyISEMNQLTSLNIYSN-QI 111
                 58************777776445*********667.77 PP

  == domain 4  score: 20.2 bits;  conditional E-value: 2.3e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L++ +Nq+   ++  ++ +++L++L++ +N +i
  EFC38043.1 100 QLTSLNIYSNQIGVEGSkyISEMKQLTSLNIGHN-QI 135
                 69***********777776445*********555.87 PP

  == domain 5  score: 22.6 bits;  conditional E-value: 4.1e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L++++Nq+   +   ++ +++L++Ld+ +N +i
  EFC38043.1 123 KQLTSLNIGHNQIGVEGAkyISEMKQLTSLDIGHN-QI 159
                 58************766676445*********666.76 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.4   0.0   5.1e-12   1.3e-08       2      61 .]      28      87 ..      27      87 .. 0.98
   2 !   32.9   0.1   1.5e-11   3.9e-08       2      61 .]     100     159 ..      99     159 .. 0.98

  Alignments for each domain:
  == domain 1  score: 34.4 bits;  conditional E-value: 5.1e-12
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsLd+s+N++ + + +  +g+++L++Ld+ +N++ +  ++ +s +++L+sLd+ +N++
  EFC38043.1 28 QLTSLDISDNQIGVEGSKYISGMKQLTSLDIYYNEIGVEGAKYISEMKQLTSLDIGNNQI 87
                7*********************************************************98 PP

  == domain 2  score: 32.9 bits;  conditional E-value: 1.5e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++ +N++ + + +  + +++L++L++++N++ +  ++ +s +++L+sLd+ +N++
  EFC38043.1 100 QLTSLNIYSNQIGVEGSKYISEMKQLTSLNIGHNQIGVEGAKYISEMKQLTSLDIGHNQI 159
                 79********************************************************98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0    0.0012         3       1      21 [.      28      48 ..      28      50 .. 0.83
   2 ?    4.5   0.0     0.028        72       1      18 [.      52      69 ..      52      74 .. 0.77
   3 !    8.5   0.0    0.0014       3.6       1      20 [.      76      95 ..      76      98 .. 0.81
   4 ?    5.6   0.0     0.012        31       1      20 [.     100     119 ..     100     122 .. 0.80
   5 !    7.2   0.0    0.0038       9.7       1      19 [.     124     142 ..     124     146 .. 0.78
   6 ?    5.2   0.1     0.017        44       1      12 [.     148     159 ..     148     160 .] 0.88

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0012
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++Ld+s+n+++  ++ +++
  EFC38043.1 28 QLTSLDISDNQIGVEGSKYIS 48
                599********9888887776 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.028
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++Ld+ +n ++  ++ 
  EFC38043.1 52 QLTSLDIYYNEIGVEGAK 69
                599*******99766655 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0014
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L++Ld++nn+++  ++ ++
  EFC38043.1 76 QLTSLDIGNNQIGVEGSKYI 95
                599********987777766 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.012
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++ +n+++  ++ ++
  EFC38043.1 100 QLTSLNIYSNQIGVEGSKYI 119
                 599*******9987777666 PP

  == domain 5  score: 7.2 bits;  conditional E-value: 0.0038
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L++++n+++  ++ +
  EFC38043.1 124 QLTSLNIGHNQIGVEGAKY 142
                 599********97666655 PP

  == domain 6  score: 5.2 bits;  conditional E-value: 0.017
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+++n++
  EFC38043.1 148 QLTSLDIGHNQI 159
                 599*******86 PP

>> RHH_3  Ribbon-helix-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.025        64      12      32 ..      27      47 ..      26      48 .. 0.92
   2 !    5.2   0.0    0.0081        21      12      35 ..      51      74 ..      50      74 .. 0.92
   3 !    7.1   0.0     0.002       5.2      12      35 ..      75      98 ..      73      98 .. 0.91
   4 !   15.0   0.0   7.2e-06     0.018      12      35 ..      99     122 ..      97     122 .. 0.93
   5 !    6.2   0.0     0.004        10      12      35 ..     123     146 ..     121     146 .. 0.91

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.025
       RHH_3 12 elaekLkaLSekTrIprSkll 32
                +++++L+   ++++++ Sk++
  EFC38043.1 27 NQLTSLDISDNQIGVEGSKYI 47
                6899999999**********8 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0081
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+ + ++++++ +k++ e+
  EFC38043.1 51 KQLTSLDIYYNEIGVEGAKYISEM 74
                68999****************886 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.002
       RHH_3 12 elaekLkaLSekTrIprSklldeA 35
                +++++L+  +++++++ Sk++ e+
  EFC38043.1 75 KQLTSLDIGNNQIGVEGSKYISEM 98
                689999***************886 PP

  == domain 4  score: 15.0 bits;  conditional E-value: 7.2e-06
       RHH_3  12 elaekLkaLSekTrIprSklldeA 35 
                 +++++L+ +S++++++ Sk++ e+
  EFC38043.1  99 NQLTSLNIYSNQIGVEGSKYISEM 122
                 799******************886 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.004
       RHH_3  12 elaekLkaLSekTrIprSklldeA 35 
                 +++++L+  +++++++ +k++ e+
  EFC38043.1 123 KQLTSLNIGHNQIGVEGAKYISEM 146
                 68999****************886 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   5.6e-05      0.14      41     127 ..      26     113 ..      18     134 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.6e-05
       LRR_9  41 ldqfdtidlsdndirkldgfPl...lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 ++q+ ++d+sdn+i  ++g  +   +k+l +l +  n i   + +    + +l++l + nn++   +  + + ++++l++l + +n +  
  EFC38043.1  26 MNQLTSLDISDNQIG-VEGSKYisgMKQLTSLDIYYNEIGVEGAKYISEMKQLTSLDIGNNQIGVEGS-KYISEMNQLTSLNIYSNQIGV 113
                 678999999999995.6666551225666777788888887777777788889999999999987777.889999999999999998754 PP

>> UPF0193  Uncharacterised protein family (UPF0193)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1     0.024        61     172     207 ..      44      79 ..      37      87 .. 0.90
   2 ?    8.1   0.2   0.00083       2.1     172     207 ..      92     127 ..      84     135 .. 0.91

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.024
     UPF0193 172 keFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                  ++++ M++L   + Y ++I  e ++ + e+++l +
  EFC38043.1  44 SKYISGMKQLTSLDIYYNEIGVEGAKYISEMKQLTS 79 
                 689999**************************9975 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00083
     UPF0193 172 keFLeeMeaLGqgkkYraiIeteIsqklrelealdk 207
                  ++++eM++L   + Y++ I  e s+ + e+++l +
  EFC38043.1  92 SKYISEMNQLTSLNIYSNQIGVEGSKYISEMKQLTS 127
                 6899****************************9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       299  (0.0166769); expected 358.6 (0.02)
Passed bias filter:                      171  (0.00953762); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1005.62
//
Query:       EFC38044.1  [L=119]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.9e-05   24.7   0.1    5.4e-05   23.8   0.1    1.4  1  Hemerythrin  Hemerythrin HHE cation binding domain


Domain annotation for each model (and alignments):
>> Hemerythrin  Hemerythrin HHE cation binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.1     3e-09   5.4e-05       5     124 ..      21     112 ..      18     118 .. 0.75

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 3e-09
                  HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHH.CCC.HHHHHHHHHHHHHHHHHHHHHHHHCHTCGGSTC CS
  Hemerythrin   5 aldeeHralrallerlraladaaaevhgalrklaelldelvdeleaHhaaEEellfPlledrpggravldvlereHdeirelleelrellkgleepsa 102
                   l e+H++l+ l+++l    da        r + ++l+el d++  H++ EE+l+           ++ +++++ Hd + + + +l   + +      
   EFC38044.1  21 ELNEQHKKLFTLINAL----DA-------KRSCGTTLKELLDYVVFHFKTEEDLF-AKAG-----WSESASHKETHDKFVQDALALT-SVGD------ 94 
                  6889**********55....45.......57799********************5.4444.....6888899999999997664444.2222...... PP

                  HHHHHHHHHHHHHHHHHHHHHH CS
  Hemerythrin 103 aafaelleeladllreHiakEe 124
                       +++ + ++l  Hi+  +
   EFC38044.1  95 ----AEMQFIKQWLITHICASD 112
                  ....246777777777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 742.58
//
Query:       EFC38045.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.045   13.6   0.0        9.5    6.2   0.0    3.1  3  Tail_spike_N  Tail spike TSP1/Gp66 receptor binding N-termina


Domain annotation for each model (and alignments):
>> Tail_spike_N  Tail spike TSP1/Gp66 receptor binding N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.12   2.2e+03      11      26 ..      32      47 ..      25      56 .. 0.80
   2 ?    3.5   0.0    0.0037        66       4      40 ..     217     252 ..     214     253 .. 0.71
   3 ?    6.2   0.0   0.00053       9.5      38      56 ..     297     317 ..     283     318 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.12
  Tail_spike_N 11 eggktFkeGaTleskr 26
                  +++ tF+  +T++s r
    EFC38045.1 32 NPTLTFQSYHTIKSFR 47
                  5667999999*99966 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.0037
  Tail_spike_N   4 skveekveggktFkeGaTleskrevlldeaekeyyvW 40 
                   s+ +e++ ++k+ ++G T+ s+++ + + ++++ ++W
    EFC38045.1 217 SNEKEMQLNIKSIQDG-TILSENDRIIYLNNQNELCW 252
                   6677888888888888.66666666666666668999 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.00053
  Tail_spike_N  38 yvWtGafPK..vVpagStPes 56 
                   + W+G++ K  +Vp++S P++
    EFC38045.1 297 VNWDGKLVKtfQVPPNSQPKN 317
                   78*******555******986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       406  (0.0226449); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 2210.38
//
Query:       EFC38046.1  [L=396]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.7e-06   25.5   0.0    1.1e-05   24.9   0.0    1.2  1  Hydrolase_4  Serine aminopeptidase, S33


Domain annotation for each model (and alignments):
>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.0   5.9e-10   1.1e-05      59     157 ..      85     182 ..      72     194 .. 0.77

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 5.9e-10
  Hydrolase_4  59 vdDlaaf.vekvk.eehpelplfllGhSmGGliallyl.lrypdkvaglilsaPalkikaklkappllklllkllgkllpklqvsnnlkadslsrdpe 153
                  v+Dl+ f ++k +  ++++l ++l ++SmGG+i++l+     +++++g+i +++al i+++    p+   ++ l ++ +p++++ n+++++ + ++ e
   EFC38046.1  85 VNDLRNFiIDKYCnGNSEGLTVILEAESMGGAIVTLLNeRFTRNEFSGIIATGAALFIQKD----PIDDPIQFLYKPKIPQIYICNSSEMSIVKDYIE 178
                  67888884466663555666******************544566999************76....566666668999999999988888888877777 PP

  Hydrolase_4 154 vvaa 157
                  + ++
   EFC38046.1 179 KSKE 182
                  7664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (396 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       605  (0.0337442); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2499.74
//
Query:       EFC38047.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       806  (0.0449551); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1449.35
//
Query:       EFC38048.1  [L=262]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-44  152.5   0.0      2e-44  151.6   0.0    1.4  1  malic     Malic enzyme, N-terminal domain


Domain annotation for each model (and alignments):
>> malic  Malic enzyme, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  151.6   0.0   1.1e-48     2e-44       1     115 [.     137     251 ..     137     254 .. 0.98

  Alignments for each domain:
  == domain 1  score: 151.6 bits;  conditional E-value: 1.1e-48
                 HTTECCCCCCHHCCCHHHHHHHHSTTCHHHHHHHHHHHGGCHHSCCCEGGGETCHHHHHTTSS.SS..EEEEE-SSSBTTTBS-GHHHHHHHHHHHHHH CS
       malic   1 qeknetlfykllkekleellpivYtPtvgeacqeyseeyrkarglylsikdkekikeilknlpeedvkvivvtdgeriLGlGdlGvagvgimvGKlaLy 99 
                 +++netlfy ++ ++++el+pi+YtPtvg+ac+++s+++rk+rg+++s  dk+++k+++ n+p e+v+vivvtdg riLGlGdlG++g gi++GKl+Ly
  EFC38048.1 137 HDRNETLFYYFIVNNIKELAPIIYTPTVGKACENFSHIFRKPRGMFFSALDKGEMKSMVYNWPVEEVDVIVVTDGGRILGLGDLGANGDGIPIGKLSLY 235
                 689************************************************************************************************ PP

                 HHHHS-EGGGEEEEEE CS
       malic 100 talagidPekvlpvvl 115
                 +a++gi+P +vlpv l
  EFC38048.1 236 VAAGGINPGRVLPVLL 251
                 **************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (262 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1036  (0.0577835); expected 358.6 (0.02)
Passed bias filter:                      725  (0.0404373); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 1588.75
//
Query:       EFC38049.1  [L=290]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.07   13.6   0.2       0.14   12.5   0.2    1.6  1  MULE      MULE transposase domain


Domain annotation for each model (and alignments):
>> MULE  MULE transposase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.2   8.1e-06      0.14      30      96 .]     155     220 ..     134     220 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8.1e-06
        MULE  30 vplafalveseneesyewllqelleevsgqrspkviitDkekallnaleevf.peakhrlClfHiakn 96 
                 +p  f + +se++e +e ++++++e v   ++  + ++D   a  + +++    ++ h +C+ H+akn
  EFC38049.1 155 IPGNFQFCKSETSELIEKVVEKFKE-VYT-DNICCTVSDAGSANWTYFTNLKsEKTFHHFCYSHLAKN 220
                 4567899******************.566.69**********9999996655499**********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (290 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1947.79
//
Query:       EFC38050.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        0.2   12.0   4.0        2.6    8.4   0.1    3.2  3  Cloacin_immun  Cloacin immunity protein


Domain annotation for each model (and alignments):
>> Cloacin_immun  Cloacin immunity protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.2      0.14   2.6e+03      43      55 ..      85      97 ..      68     110 .. 0.60
   2 ?    3.3   0.0    0.0057     1e+02      19      56 ..     177     214 ..     168     238 .. 0.84
   3 ?    8.4   0.1   0.00015       2.6       2      52 ..     324     376 ..     323     377 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.14
  Cloacin_immun 43 innGafdvkkeWv 55
                    +nG+ + +++W+
     EFC38050.1 85 TQNGWVNRLENWL 97
                   4444444444443 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.0057
  Cloacin_immun  19 eeyskDlGdDgslieklglplddninnGafdvkkeWvs 56 
                     e+  DlG+  s+i ++  ++ +++ n +   ++eW +
     EFC38050.1 177 LEVIADLGHLYSIITRIPQTFCEQVVNNWQVPQHEWKE 214
                    68899****************99988877766778865 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.00015
  Cloacin_immun   2 lkLkleWfdkkte..efvGeeyskDlGdDgslieklglplddninnGafdvkk 52 
                    +++ le f+k+++   f+ e+ sk l  + s +++l + +++ni+  +f+++k
     EFC38050.1 324 IQVALENFEKANKifAFILENPSKSLTIESSKVKELKSKIEENIKIANFELEK 376
                    5778999***9993346789*****************************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1344  (0.0749624); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.22s 00:00:00.68 Elapsed: 00:00:00.40
# Mc/sec: 2806.01
//
Query:       EFC38051.1  [L=1127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-10   39.9   0.3    6.5e-10   38.9   0.3    1.5  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.9   0.3   3.7e-14   6.5e-10       5     172 ..     845    1024 ..     841    1037 .. 0.80

  Alignments for each domain:
  == domain 1  score: 38.9 bits;  conditional E-value: 3.7e-14
  Guanylate_cyc    5 sydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp........eekaahaaklaelaLdmleal. 89  
                     ++++ tilF++++g  +++   +    ++++ e+ + + ++++ +k+  +++ G + m+++  +        ++++ +a+ +a   + m+e+  
     EFC38051.1  845 TKKHLTILFCELAGCDKMADTIDIPLFLEMITEYSSIMCKIIQDHKGMIDRFDGGTAMCLFSFQdntlipteQNQEVNACHAAMDIIYMMEDFk 938 
                     56789*****************99999************************************999**99754444444444444456666665 PP

  Guanylate_cyc   90 eevaveskeglkvrvGihtGpvvagviG..akkprydvwGntvnlAsrmes..tgkagkiqvseetyellkeeqfeltergevevkG 172 
                     ++ ++++ + +++ +Gi++G++  g      ++  y v G +  +As ++    + + ++ + eet    k + f +  ++ v   G
     EFC38051.1  939 TKWQKRTGHPIHIEIGINSGEIYYGNFNctDSRSSYSVLGASLDIASTLQRfnFSYSTQVLIGEETFLKVK-DIFVCYFVDLVRFSG 1024
                     77777779*****************9877799***************999622567788888999887777.666666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1005  (0.0560544); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.90u 0.31s 00:00:01.21 Elapsed: 00:00:00.51
# Mc/sec: 6673.85
//
Query:       EFC38052.1  [L=463]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0011   19.3   0.3       0.31   11.4   0.1    2.6  2  BTB_2     BTB/POZ domain
  ------ inclusion threshold ------
      0.039   13.7   0.0      0.069   12.8   0.0    1.4  1  DUF1681   Protein of unknown function (DUF1681)


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.1   3.5e-05      0.31       1      18 [.     228     245 ..     228     247 .. 0.94
   2 !    5.6   0.0    0.0022        20      57      89 ..     247     282 ..     245     289 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3.5e-05
                 EEEEETTEEEEEEHHHHH CS
       BTB_2   1 vklnVgGtrfetskstLs 18 
                 v+lnVgG +f+t+++tL+
  EFC38052.1 228 VTLNVGGQIFQTTSKTLR 245
                 89**************96 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0022
                 HHHHHS....S-B---TTS-HHHHHHHHHHHT--TT CS
       BTB_2  57 Lnyyrtg...gkLhrpeevelkslleElefygleel 89 
                 Lny+r+g   gk ++ +  +l+++ +E+++++l   
  EFC38052.1 247 LNYIRDGkliGKWNEITSDTLEKITHEAKYFKLPGI 282
                 89****666666677778889999********9765 PP

>> DUF1681  Protein of unknown function (DUF1681)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   7.7e-06     0.069      48     102 ..     303     364 ..     262     396 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.7e-06
     DUF1681  48 ekvdikL......edkstgelfaaapvetkeaavekvlDSsRyFv...lrvedekgrkavlGig 102
                 e++++++      +++++g+lfa   ++ +++ ve + D  RyFv   lr    +  +  +G+ 
  EFC38052.1 303 EECQLRFynqevvKKSESGSLFACLDYHINKQLVECCKDPFRYFVkflLR--YGESSNLAIGVT 364
                 566666666666578889**********999************9832223..222445555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (463 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1590  (0.0886831); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.28s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2675.95
//
Query:       EFC38053.1  [L=656]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-06   28.5   0.0    1.1e-05   26.0   0.0    2.3  2  Ank_2     Ankyrin repeats (3 copies)
    4.1e-05   23.6   0.0        5.1    8.0   0.0    4.5  4  Ank_3     Ankyrin repeat
    8.4e-05   22.8   0.0       0.16   12.5   0.2    3.5  2  Ank       Ankyrin repeat
  ------ inclusion threshold ------
      0.039   14.2   0.1       0.09   13.0   0.1    1.7  1  BRAP2     BRCA1-associated protein 2
       0.11   12.3   0.0       0.32   10.8   0.0    1.8  1  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom
        2.9    8.7   5.3         49    4.8   0.1    2.7  2  SUZ       SUZ domain


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.3   3.8e+03      53      65 ..     348     360 ..     330     364 .. 0.77
   2 !   26.0   0.0   3.5e-09   1.1e-05       1      79 [.     526     611 ..     526     617 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.3
       Ank_2  53 grtpLhyAarsgh 65 
                 +++ L++A  +gh
  EFC38053.1 348 NKSYLMIALTHGH 360
                 5678888888887 PP

  == domain 2  score: 26.0 bits;  conditional E-value: 3.5e-09
       Ank_2   1 LhlAakn.gnlelvklLl.egadpn.k.ngktaLhyAakngnleivklLleh......ad.ndgrtpLhyAarsghleivklLlekgadi 79 
                 Lh+Aa++ ++++ +k ++ +gadp+    g t+L++A +      +k L+++      +   +  +++ +A++ ++  ivk+L+++  d+
  EFC38053.1 526 LHFAARKtNSPSSIKTIIrKGADPDyRiGGYTPLMVAKSPA---HLKVLIQAgarleeVSqPHKLSVMACAVERKSHSIVKYLINH-HDY 611
                 8*****867789************97369******998864...489***966564452257788999999999877*******65.344 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.86   2.6e+03       3      16 ..     349     362 ..     347     375 .. 0.87
   2 !    7.4   0.0    0.0027         8       6      30 ..     526     550 ..     524     550 .. 0.91
   3 ?    1.9   0.0      0.17     5e+02       2      22 ..     555     572 ..     554     579 .. 0.64
   4 !    8.0   0.0    0.0017       5.1       4      29 ..     588     613 ..     585     615 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.86
       Ank_3   3 etpLhlAarsgnle 16 
                  + L++A+ +g+++
  EFC38053.1 349 KSYLMIALTHGHPT 362
                 578********985 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0027
       Ank_3   6 LhlAarsgnle.ivkfLlenkgadvn 30 
                 Lh+Aar +n +  +k +++ kgad++
  EFC38053.1 526 LHFAARKTNSPsSIKTIIR-KGADPD 550
                 9*********656******.9***96 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.17
       Ank_3   2 GetpLhlAarsgnleivkfLl 22 
                 G+tpL++A + ++   +k L+
  EFC38053.1 555 GYTPLMVAKSPAH---LKVLI 572
                 89****6644444...45555 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0017
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadv 29 
                 + + +A++  +++ivk+L++++   v
  EFC38053.1 588 SVMACAVERKSHSIVKYLINHHDYAV 613
                 566689999999********988766 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.0    0.0076        23       6      28 ..     526     550 ..     526     552 .. 0.87
   2 !   12.5   0.2   5.2e-05      0.16       2      23 ..     555     608 ..     554     616 .. 0.65

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0076
                 HHHHH.HHTTHHHHHHHH.TTTSTT CS
         Ank   6 LHlAa.tngkkriiklLL.hGAnln 28 
                 LH Aa   ++++ ik ++ +GA+++
  EFC38053.1 526 LHFAArKTNSPSSIKTIIrKGADPD 550
                 9**99855889*******88***98 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 5.2e-05
                 SBBHHHHH.............................H..HHTTHHHHHHHH.T CS
         Ank   2 GnTPLHlA.............................a..tngkkriiklLL.h 23 
                 G+TPL++A                             +   +++++i+k+L+ h
  EFC38053.1 555 GYTPLMVAkspahlkvliqagarleevsqphklsvmaCavERKSHSIVKYLInH 608
                 9******655555555555555555555555555444345888899****9975 PP

>> BRAP2  BRCA1-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1     3e-05      0.09       6      74 ..     228     295 ..     222     324 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3e-05
       BRAP2   6 rstllcilavPsylsladllkFvgsvlekvseiriirdgkenrymvLikfkdqesadeFykefngkkFs 74 
                 ++ +  i+ vPs  +++d+  +v + ++ + +   i++++ +r  +++ +k++++a+e +k+ +g k +
  EFC38053.1 228 KEFCAKIIGVPSSYTISDIHDLVLERCSIICNQICIKEKRGKRT-AILDMKSKKEAQEVKKNIEGIKVE 295
                 45566799*****************************9998885.6789************99998765 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00011      0.32       6      70 .]     237     300 ..     234     300 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00011
                 ETTTSSHHHHHHHHHTTSCEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEEE CS
       RRM_1   6 LppdvteeeLkelFskfGpiksiklvrdetgkskgfafVeFeskedAekAlealngkklggrelk 70 
                 +p+++t +++++l  +  +i   +++  + ++ k++a+ +++sk +A++ +++  g k++ +elk
  EFC38053.1 237 VPSSYTISDIHDLVLERCSIICNQICI-KEKRGKRTAILDMKSKKEAQEVKKNIEGIKVELHELK 300
                 677777777777766644555556666.599***************************9999885 PP

>> SUZ  SUZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   1.9      0.02        61       9      45 ..      49     107 ..      37     109 .. 0.75
   2 ?    4.8   0.1     0.016        49       3      28 ..     300     325 ..     298     339 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.02
         SUZ   9 kRpsssssssssrgssgasssesssss......................ktleEREaeY 45 
                 kR+s  ++ +ss++s +  +++++++                       k leE ++eY
  EFC38053.1  49 KRASEHPTYNSSKSSEADDTNNQAQARgiprrkllvlnilqhqlaetrqKRLEEQQQEY 107
                 5666666655555555555444444448899999************************* PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.016
         SUZ   3 pkmkIlkRpsssssssssrgssgass 28 
                 + ++I+k+ +++ +ss s+ +++++s
  EFC38053.1 300 KVRVIMKKKNQAANSSLSTTENTKQS 325
                 6799*******998666666665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (656 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2103  (0.117296); expected 358.6 (0.02)
Passed bias filter:                      564  (0.0314574); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.78u 0.30s 00:00:01.08 Elapsed: 00:00:00.51
# Mc/sec: 3906.72
//
Query:       EFC38054.1  [L=1125]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-08   32.4   3.5    3.6e-07   30.6   3.5    2.1  1  GPS       GPCR proteolysis site, GPS, motif
      2e-05   24.4   4.6        1.7    8.8   0.0    5.9  7  NHL       NHL repeat
    7.4e-05   23.0  27.6      0.011   16.1   8.2    2.8  2  EGF_2     EGF-like domain
     0.0089   15.8   0.1      0.015   15.1   0.1    1.2  1  Alpha-E   A predicted alpha-helical domain with a conserved E
  ------ inclusion threshold ------
      0.049   13.9  13.5       0.72   10.2   2.8    2.8  2  EGF       EGF-like domain
       0.11   13.0   2.4       0.44   11.0   2.4    2.1  1  DUF2569   Protein of unknown function (DUF2569)


Domain annotation for each model (and alignments):
>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   3.5   1.2e-10   3.6e-07       2      43 ..     982    1021 ..     981    1023 .. 0.86

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 1.2e-10
         GPS    2 sCvfWdeeneetgsWsteGCel.tesdnknetvCsCnHLtsFA 43  
                   C +Wd   e+  +Ws++GC l   +++++e+ CsC+H+t F+
  EFC38054.1  982 ACKYWD---ESALAWSSRGCYLkGYNLTSQEILCSCSHTTMFT 1021
                  5****6...5679*******77666779************996 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.68     2e+03      18      26 ..       3      11 ..       2      12 .. 0.84
   2 !    5.2   0.0    0.0079        24       3      28 .]      47      71 ..      46      71 .. 0.91
   3 !    8.8   0.0   0.00058       1.7      11      27 ..     111     127 ..     105     128 .. 0.88
   4 ?   -0.8   0.0      0.62   1.9e+03      11      26 ..     208     223 ..     201     224 .. 0.88
   5 !    5.9   0.0    0.0047        14       6      27 ..     294     315 ..     290     316 .. 0.94
   6 ?   -3.8   0.1       5.6   1.7e+04       5      12 ..     347     354 ..     347     354 .. 0.79
   7 ?   -2.5   0.0       2.2   6.7e+03       4      17 ..     653     666 ..     653     666 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.68
                EECCCTEEE CS
         NHL 18 aDsenhrvq 26
                +Ds++h++ 
  EFC38054.1  3 TDSHHHSLL 11
                9*****986 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0079
                SEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrvqvF 28
                +P G+++ + G +yVa + ++r+++F
  EFC38054.1 47 QPDGITY-NAGSLYVALNATNRIVKF 71
                799****.6*******9999999998 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00058
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                 s+G iy++D+ n r+++
  EFC38054.1 111 SDGTIYITDCSNDRIRK 127
                 89**********99986 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 0.62
                 TTTEEEEEECCCTEEE CS
         NHL  11 snGdiyVaDsenhrvq 26 
                 snG+ y  D++n+ ++
  EFC38054.1 208 SNGEYYFLDYGNNAIR 223
                 79999999*****997 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.0047
                 EEEEETTTEEEEEECCCTEEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvqv 27 
                 G+++  +G++y +D++n r+++
  EFC38054.1 294 GITLGVSGEVYFSDYGNGRIRK 315
                 899999**************97 PP

  == domain 6  score: -3.8 bits;  conditional E-value: 5.6
                 EEEEEETT CS
         NHL   5 hGvavdsn 12 
                 +Gv+++++
  EFC38054.1 347 NGVCINND 354
                 69***865 PP

  == domain 7  score: -2.5 bits;  conditional E-value: 2.2
                 EEEEEEETTTEEEE CS
         NHL   4 PhGvavdsnGdiyV 17 
                 P++++++s+G ++V
  EFC38054.1 653 PQSTSANSTGGVLV 666
                 888999*****998 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1  11.4   6.6e-05       0.2       5      32 .]     341     368 ..     335     368 .. 0.86
   2 !   16.1   8.2   3.6e-06     0.011       6      32 .]     384     409 ..     375     409 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 6.6e-05
       EGF_2   5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                   +C+g+G+C+n   +C C  sg++G +C
  EFC38054.1 341 AGACSGNGVCINND-VCACtVSGFSGTYC 368
                 568*******9566.8************* PP

  == domain 2  score: 16.1 bits;  conditional E-value: 3.6e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ghG+Cv+++ +C+C sgy   +C
  EFC38054.1 384 TTCSGHGSCVSLN-NCSCLSGYDAIDC 409
                 58********999.8*******88888 PP

>> Alpha-E  A predicted alpha-helical domain with a conserved ER motif.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.1     5e-06     0.015      41     131 ..     692     786 ..     676     824 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 5e-06
     Alpha-E  41 rallaalgaeegfeeryeeae...leevlkfllldeenpgSiasclraarenaravRerlssemWevlnelylelkeklsel.eflervkerlaa 131
                 ++ll++++ ++++++ +++++   + e++k+++ d++np + + ++++a  n +av  r+ +e+ + +n+++ +l+++ +e+ +++  vk++la+
  EFC38054.1 692 SSLLTVFSYDTSLSAANSTSSsdvALEIVKSVVIDPKNPTTALTAIQQATSNPEAVDSRVITELTNKINNFVATLNTNYKEErALYGFVKSKLAT 786
                 566777777777744442222457999******************************************98888886443333555555555544 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   3.1    0.0011       3.2       6      31 ..     344     366 ..     338     367 .. 0.89
   2 ?   10.2   2.8   0.00024      0.72       4      29 ..     382     405 ..     380     407 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0011
                 STTT-EEEEETTTEEEEEEC.TTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCp.eGytGk 31 
                 Cs++G C+++      C C+ +G++G 
  EFC38054.1 344 CSGNGVCINND----VCACTvSGFSGT 366
                 *******9999....*****999*995 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00024
                 TT..STTT-EEEEETTTEEEEEECTTEE CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGyt 29 
                 +p  Cs++G Cv++     +C C +Gy+
  EFC38054.1 382 QPttCSGHGSCVSLN----NCSCLSGYD 405
                 5556***********....********7 PP

>> DUF2569  Protein of unknown function (DUF2569)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   2.4   0.00015      0.44      29     114 ..    1019    1100 ..    1005    1123 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00015
     DUF2569   29 alkalfsleewstlknleslltlllileiitnialvafsilllvlffkrrksfP..klyiifllanlvlalidalllspifekldaqa 114 
                  ++ ++++ ++ +   + ++++ ++++++i++ i+ ++ si++l l++  ++  P     i+ +l +++l++  +ll++       + a
  EFC38054.1 1019 MFTTFVEQNTSTIPASVKETVAAFYYGQIALGIFYFLTSIVILCLLIIFKNEQPisSRLITPYLGMIALIVE-SLLVYIT-----QRA 1100
                  33344444444444555559*******************999888766666665115567777777777777.5554443.....222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1125 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       986  (0.0549947); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.87u 0.30s 00:00:01.17 Elapsed: 00:00:00.53
# Mc/sec: 6421.78
//
Query:       EFC38055.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   14.7   0.1      0.038   13.8   0.1    1.5  1  LapA_dom  Lipopolysaccharide assembly protein A domain


Domain annotation for each model (and alignments):
>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   2.1e-06     0.038      19      46 ..     144     171 ..     139     195 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.1e-06
    LapA_dom  19 LsllllvafgiGallgwllslwsylrlr 46 
                 L +l+++++g+G++++++++++ yl++r
  EFC38055.1 144 LMILIILTAGLGVVFIFIIFVFPYLKNR 171
                 789******************9999855 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1203  (0.067098); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.43
# Mc/sec: 1766.38
//
Query:       EFC38056.1  [L=514]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1059  (0.0590663); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.27s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 3203.11
//
Query:       EFC38057.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-13   50.0   3.0    1.3e-06   28.9   0.3    2.2  3  Ank_2     Ankyrin repeats (3 copies)
    2.1e-08   34.3   0.3    5.9e-07   29.6   0.3    2.8  3  Ank_5     Ankyrin repeats (many copies)
    7.8e-05   23.2   0.2      0.001   19.6   0.1    2.7  3  Ank_4     Ankyrin repeats (many copies)
    0.00013   22.1   0.3      0.081   13.5   0.1    3.8  4  Ank_3     Ankyrin repeat
  ------ inclusion threshold ------
      0.021   15.3   0.1       0.27   11.7   0.1    2.5  3  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   0.2   6.1e-10   2.2e-06      28      80 ..      49     109 ..      10     114 .. 0.79
   2 !   28.9   0.3   3.7e-10   1.3e-06       2      71 ..      52     135 ..      51     148 .. 0.68
   3 ?    2.2   0.0     0.077   2.8e+02      25      70 ..     116     162 ..     106     166 .] 0.50

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 6.1e-10
       Ank_2  28 taLhyAakngnleivklLleh.......adndgrtpLhyAarsghleivklLlek.gadin 80 
                  + +y + ng+  + ++L++h       +d++g+t Lh+Aa +g l++++ Ll+  +ad+ 
  EFC38057.1  49 PPPMYTVWNGHFSMFSYLIDHnlvnfemTDETGNTYLHIAALKGDLNFINKLLNLdEADVL 109
                 566889999***********999777766699*********************54577764 PP

  == domain 2  score: 28.9 bits;  conditional E-value: 3.7e-10
       Ank_2   2 hlAakngnlelvklLl..egadpn..k.ngktaLhyAakngnleivklLleh......adnd...grtpLhyAarsghleivkl 71 
                 ++ + ng+++++ +L+  + ++++  + +g+t Lh+Aa +g+l+++  Ll+       ++++   g+t+  +A + ++ +i+ +
  EFC38057.1  52 MYTVWNGHFSMFSYLIdhNLVNFEmtDeTGNTYLHIAALKGDLNFINKLLNLdeadvlVNKKdfvGKTAFELAEQRNRMDIATM 135
                 566778888888888865445554543688888888888888888888887334445533223558888888887787777765 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.077
       Ank_2  25 ngktaLhyAakngnleivklLleh..adndgrtpLhyAarsghleivk 70 
                  gkta  +A +++  + + +++      ++ +t+L++  ++g+l  ++
  EFC38057.1 116 VGKTAFELAEQRNRMD-IATMIRSikYSKKLHTALFNQFSKGNLSDIQ 162
                 3566666666666444.3444433234455666666655556555555 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.45   1.6e+03      22      33 ..      12      23 ..       8      36 .. 0.65
   2 ?    3.3   0.0     0.031   1.1e+02      23      46 ..      54      73 ..      52      76 .. 0.76
   3 !   29.6   0.3   1.7e-10   5.9e-07       1      56 []      66     124 ..      66     124 .. 0.95

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.45
       Ank_5 22 vAakygaadvvr 33
                +A+++g+++ ++
  EFC38057.1 12 TACRRGNLNGFL 23
                566666665544 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.031
       Ank_5 23 AakygaadvvrlLlargadlnltd 46
                 +++g+++++ +L+    d nl +
  EFC38057.1 54 TVWNGHFSMFSYLI----DHNLVN 73
                589***********....555555 PP

  == domain 3  score: 29.6 bits;  conditional E-value: 1.7e-10
       Ank_5   1 LlehgpadvnrldgggntpLhvAakygaadvvrlLl...argadlnltdsrGltaldlA 56 
                 L++h  ++   +d+ gnt Lh+Aa +g ++ +++Ll   +  +  n +d+ G+ta++lA
  EFC38057.1  66 LIDHNLVNFEMTDETGNTYLHIAALKGDLNFINKLLnldEADVLVNKKDFVGKTAFELA 124
                 67888888899**********************************************99 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       2.3   8.1e+03      42      48 ..      13      19 ..       5      22 .. 0.76
   2 !   19.6   0.1   2.8e-07     0.001      12      54 ..      58     100 ..      52     101 .. 0.90
   3 ?   -0.1   0.0      0.43   1.6e+03       3      15 ..     147     159 ..     145     166 .] 0.64

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.3
       Ank_4 42 Aakrgnv 48
                A++rgn+
  EFC38057.1 13 ACRRGNL 19
                7778875 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 2.8e-07
       Ank_4  12 grlelvrlLlek.gadinaqdnrsGetalhiAakrgnveilklL 54 
                 g++ +  +L+++  ++  ++ ++ G+t lhiAa++g+++++  L
  EFC38057.1  58 GHFSMFSYLIDHnLVNFEMT-DETGNTYLHIAALKGDLNFINKL 100
                 8999*******977*****9.****************9987666 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.43
       Ank_4   3 taLhyaaisgrle 15 
                 taL++++++g+l 
  EFC38057.1 147 TALFNQFSKGNLS 159
                 6777877777775 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.87   3.1e+03       8      15 ..      12      19 ..      10      29 .. 0.79
   2 ?    3.3   0.0     0.047   1.7e+02      12      27 ..      57      72 ..      57      76 .. 0.82
   3 !   13.5   0.1   2.3e-05     0.081       2      29 ..      81     108 ..      80     110 .. 0.86
   4 ?   -0.7   0.0      0.94   3.4e+03       5      15 ..     144     154 ..     141     166 .] 0.64

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.87
       Ank_3  8 lAarsgnl 15
                +A+r gnl
  EFC38057.1 12 TACRRGNL 19
                69999997 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.047
       Ank_3 12 sgnleivkfLlenkga 27
                +g++++  +L++++ +
  EFC38057.1 57 NGHFSMFSYLIDHNLV 72
                799*********7655 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 2.3e-05
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                 G+t Lh+Aa+ g+l+ +  Ll+   adv
  EFC38057.1  81 GNTYLHIAALKGDLNFINKLLNLDEADV 108
                 9**************9999998666666 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.94
       Ank_3   5 pLhlAarsgnl 15 
                  Lh+A+ ++  
  EFC38057.1 144 KLHTALFNQFS 154
                 68888877665 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       3.4   1.2e+04       9      18 ..      13      29 ..      13      31 .. 0.54
   2 ?    0.3   0.0      0.32   1.2e+03       7      23 ..      52      69 ..      52      77 .. 0.76
   3 ?   11.7   0.1   7.6e-05      0.27       2      30 ..      81     113 ..      80     115 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.4
                HHHHTT.......HHHH CS
         Ank  9 Aatngk.......krii 18
                A+++g+        +ii
  EFC38057.1 13 ACRRGNlngfltiMNII 29
                67677655555555555 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.32
                HHHHHHTTHHHHHHHH.T CS
         Ank  7 HlAatngkkriiklLL.h 23
                ++ ++ng+ ++ ++L+ h
  EFC38057.1 52 MYTVWNGHFSMFSYLIdH 69
                56678999999999*954 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 7.6e-05
                 SBBHHHHHHHHTTHHHHHHHH..TTTS..TTCB CS
         Ank   2 GnTPLHlAatngkkriiklLL..hGAn..lnal 30 
                 GnT LH+Aa  g+++ i  LL  + A+  +n +
  EFC38057.1  81 GNTYLHIAALKGDLNFINKLLnlDEADvlVNKK 113
                 9********9999****9898656688655655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       586  (0.0326845); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 964.40
//
Query:       EFC38058.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.021   14.6   0.3      0.038   13.7   0.3    1.4  1  Vpu       Vpu protein
      0.062   13.3   0.0       0.15   12.1   0.0    1.6  1  DUF2701   Protein of unknown function (DUF2701)


Domain annotation for each model (and alignments):
>> Vpu  Vpu protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.3   4.3e-06     0.038       4      51 ..      76     124 ..      71     127 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 4.3e-06
         Vpu   4 leliglialivaliiaivvWtivyreykkikkq.keierlikrirerae 51 
                 l  i++i l+  l+   ++  i y ++k+ k+  k+++++i+ri er++
  EFC38058.1  76 LIFIAIITLGCGLVFFPCLLLIQYLHWKHVKNYdKNVKERIHRILEREN 124
                 44599999999****9**************99879************86 PP

>> DUF2701  Protein of unknown function (DUF2701)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   1.6e-05      0.15       2      41 ..      83     122 ..      82     128 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.6e-05
     DUF2701   2 tvfvvvivilvflllylvkwslvkdalnsiklkilnattr 41 
                 t+ +  +++ + ll++  +w  vk+  +++k +i +++ r
  EFC38058.1  83 TLGCGLVFFPCLLLIQYLHWKHVKNYDKNVKERIHRILER 122
                 66677899************************99887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       756  (0.0421663); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1307.23
//
Query:       EFC38059.1  [L=477]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0044   17.0   2.9      0.026   14.4   0.3    2.8  2  DUF4957        Domain of unknown function (DUF4957)
     0.0058   16.6   1.2     0.0058   16.6   1.2    1.8  2  HEPN_AbiA_CTD  HEPN like, Abia C-terminal domain


Domain annotation for each model (and alignments):
>> DUF4957  Domain of unknown function (DUF4957)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.2     0.027   2.4e+02      40      68 ..      63      91 ..      35     131 .. 0.73
   2 !   14.4   0.3   2.9e-06     0.026      66     110 ..     272     321 ..     261     335 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.027
     DUF4957 40 gasLkiknldldgsasdssfialsetpde 68
                ++++++ ++ +d+ a+d+  i +  +++ 
  EFC38059.1 63 NTKITLSEVSIDCLANDDVQIRICHQKKL 91
                3489999******9999998888766554 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 2.9e-06
     DUF4957  66 pdeti.....kdtltiqnCeikdvnkgliydnnkkyviesivinnclvkn 110
                 + +++      d++   n+ ++ ++++liy n +k++ +++ i+++++++
  EFC38059.1 272 KTNNLlltfkLDKIRYYNSYFDRLTNTLIYLNRQKICFKKLHIEENIIET 321
                 333334777779999*******************************9975 PP

>> HEPN_AbiA_CTD  HEPN like, Abia C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   1.2   6.5e-07    0.0058      18      54 ..     265     306 ..     255     321 .. 0.77
   2 ?   -3.2   0.0      0.86   7.7e+03      32      46 ..     436     450 ..     426     464 .. 0.66

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 6.5e-07
  HEPN_AbiA_CTD  18 fmylcekkkanllaaya.....yyknyfdrvtadldflaydk 54 
                     +yl ekk +nll ++      yy +yfdr+t  l +l+ +k
     EFC38059.1 265 VVYLFEKKTNNLLLTFKldkirYYNSYFDRLTNTLIYLNRQK 306
                    579********99888444444*************9994333 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.86
  HEPN_AbiA_CTD  32 ayayyknyfdrvtad 46 
                    +++ y  yfd  + d
     EFC38059.1 436 DFSIYLRYFDESSYD 450
                    577778888865443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (477 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       829  (0.0462379); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 2722.66
//
Query:       EFC38060.1  [L=477]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-27   94.6  33.3      3e-09   36.7   3.2    7.2  7  SapB_1    Saposin-like type B, region 1
    3.7e-24   84.5  40.5    5.6e-10   39.2   1.0    6.9  6  SapB_2    Saposin-like type B, region 2
  ------ inclusion threshold ------
      0.085   12.6   0.1       0.16   11.7   0.1    1.4  1  SLATT_2   SMODS and SLOG-associating 2TM effector domain 2


Domain annotation for each model (and alignments):
>> SapB_1  Saposin-like type B, region 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.6   3.2e-10   1.9e-06       2      38 .]      31      65 ..      30      65 .. 0.96
   2 !   36.7   3.2     5e-13     3e-09       2      38 .]     119     155 ..     118     155 .. 0.97
   3 ?   -1.6   0.1       0.5     3e+03       4      11 ..     160     167 ..     160     168 .. 0.84
   4 !    8.4   0.2   0.00036       2.2       2      35 ..     211     243 ..     210     246 .. 0.83
   5 ?   -1.0   0.0      0.31   1.9e+03       4      14 ..     248     258 ..     248     263 .. 0.82
   6 !   14.3   0.2   5.1e-06      0.03       3      38 .]     306     341 ..     304     341 .. 0.96
   7 !   26.2   0.2   9.9e-10   5.9e-06       2      35 ..     386     419 ..     385     421 .. 0.96

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 3.2e-10
                HHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHHHS- CS
      SapB_1  2 eCdlCefvVkeveklLkdNkTeeeIieaLekvCskLP 38
                 C++Ce++V  +e l++  kT+ +I++ L +vCskL+
  EFC38060.1 31 GCEICEWLVATAEGLVN--KTKPQIEQELLQVCSKLG 65
                5***************9..9***************96 PP

  == domain 2  score: 36.7 bits;  conditional E-value: 5e-13
                 HHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHHHS- CS
      SapB_1   2 eCdlCefvVkeveklLkdNkTeeeIieaLekvCskLP 38 
                  C++C+ vV++ve+++++N+T   +++ Le+vC+ +P
  EFC38060.1 119 ICNMCQLVVTQVENWVESNDTIMTLEKKLEQVCNVIP 155
                 6*********************************998 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.5
                 HHHHHHHH CS
      SapB_1   4 dlCefvVk 11 
                 +lC+++V 
  EFC38060.1 160 TLCTYAVE 167
                 69****96 PP

  == domain 4  score: 8.4 bits;  conditional E-value: 0.00036
                 HHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHH CS
      SapB_1   2 eCdlCefvVkeveklLkdNkTeeeIieaLekvCs 35 
                 +C +C+ +V+ +++ ++       I++ Le +C+
  EFC38060.1 211 LCPICKAAVGFLKSKIS-TVDVPTIKKQLEFACT 243
                 7*************999.5778888888887776 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 0.31
                 HHHHHHHHHHH CS
      SapB_1   4 dlCefvVkeve 14 
                 ++C+++V ++ 
  EFC38060.1 248 EDCQQLVDKAA 258
                 68*****9985 PP

  == domain 6  score: 14.3 bits;  conditional E-value: 5.1e-06
                 HHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHHHS- CS
      SapB_1   3 CdlCefvVkeveklLkdNkTeeeIieaLekvCskLP 38 
                 C  C  + +++e+ +++    +e+i+  +  C+kL+
  EFC38060.1 306 CPTCLAITQYLENAITSDVAVAELIKIADLGCAKLG 341
                 *********************************996 PP

  == domain 7  score: 26.2 bits;  conditional E-value: 9.9e-10
                 HHHHHHHHHHHHHHHH-SS--HHHHHHHHHHHHH CS
      SapB_1   2 eCdlCefvVkeveklLkdNkTeeeIieaLekvCs 35 
                 +C  Ce+v++ ++++L  N T++ +++ L+ vC+
  EFC38060.1 386 MCLGCEYVIGVADNWLIANNTQQSVESTLDMVCN 419
                 8********************************9 PP

>> SapB_2  Saposin-like type B, region 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1      0.39   2.3e+03      26      32 ..      59      65 ..      59      65 .. 0.90
   2 !   24.3   3.4     4e-09   2.4e-05       1      34 []      69     102 ..      69     102 .. 0.97
   3 !   24.7   2.8   3.1e-09   1.9e-05       3      34 .]     162     193 ..     160     193 .. 0.96
   4 !    5.4   1.7    0.0034        21       3      30 ..     250     275 ..     248     280 .. 0.89
   5 !   12.9   0.3   1.5e-05     0.088      18      34 .]     348     364 ..     347     364 .. 0.91
   6 !   39.2   1.0   9.4e-14   5.6e-10       2      34 .]     429     462 ..     428     462 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.39
                HHHHHTT CS
      SapB_2 26 evCtalg 32
                +vC++lg
  EFC38060.1 59 QVCSKLG 65
                79***98 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 4e-09
                 HHHHHHHHHHHHHHHCCHCTT--HHHHHHHTTSS CS
      SapB_2   1 deCkslVdqYgpliiqlLlseldPkevCtalglC 34 
                 + C+++V + +p ii+ +++++ P  vC+++++C
  EFC38060.1  69 QLCDQMVLMELPDIIDAIIAKEPPAIVCAQVKIC 102
                 56******************************** PP

  == domain 3  score: 24.7 bits;  conditional E-value: 3.1e-09
                 HHHHHHHHHHHHHCCHCTT--HHHHHHHTTSS CS
      SapB_2   3 CkslVdqYgpliiqlLlseldPkevCtalglC 34 
                 C   V+qY+p++i +++++ +P ++C+++ lC
  EFC38060.1 162 CTYAVEQYLPTFIHQVEQQYSPLVICQDVSLC 193
                 8889**************************** PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.0034
                 HHHHHHHHHHHHHCCHCTT--HHHHHHH CS
      SapB_2   3 CkslVdqYgpliiqlLlseldPkevCta 30 
                 C++lVd+ +  i q ++ e d++++C+ 
  EFC38060.1 250 CQQLVDK-AADIAQAIQTE-DANTICSS 275
                 99****9.9999999***9.******97 PP

  == domain 5  score: 12.9 bits;  conditional E-value: 1.5e-05
                 HCTT--HHHHHHHTTSS CS
      SapB_2  18 LlseldPkevCtalglC 34 
                 +l++++P++vC+ l++C
  EFC38060.1 348 ILEKVTPQKVCSTLKMC 364
                 67889************ PP

  == domain 6  score: 39.2 bits;  conditional E-value: 9.4e-14
                 HHHHHHHHHHHHHHCCHCTT--.HHHHHHHTTSS CS
      SapB_2   2 eCkslVdqYgpliiqlLlseld.PkevCtalglC 34 
                 +C  lV qY+p+++ql+++++  P++vC+a+g+C
  EFC38060.1 429 QCVALVAQYTPQLVQLFEAKVFnPQTVCKAIGVC 462
                 9*******************555*********** PP

>> SLATT_2  SMODS and SLOG-associating 2TM effector domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   2.7e-05      0.16      62     125 ..     358     421 ..     347     434 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.7e-05
     SLATT_2  62 gaalplldltgvleeaaawgllalllaaacvaadryfGltsGwlrdvataqavqrrlealqfdw 125
                  ++l + d ++ ++ aa+  ++ +  +  c++++ ++G++  wl +  t q+v+  l+++  d+
  EFC38060.1 358 CSTLKMCDAADKMSLAAPVIAAKVEDSSMCLGCEYVIGVADNWLIANNTQQSVESTLDMVCNDF 421
                 567889999999999***99999********************************999987776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (477 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       874  (0.0487478); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 2848.68
//
Query:       EFC38061.1  [L=447]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (447 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       458  (0.0255452); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.44
# Mc/sec: 3030.85
//
Query:       EFC38062.1  [L=535]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
       0.14   11.0   1.9       0.15   10.9   0.1    1.9  2  DNA_topoisoIV  DNA gyrase/topoisomerase IV, subunit A


Domain annotation for each model (and alignments):
>> DNA_topoisoIV  DNA gyrase/topoisomerase IV, subunit A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   8.2e-06      0.15     275     371 ..     105     196 ..      83     297 .. 0.74
   2 ?   -2.1   0.2     0.073   1.3e+03     257     316 ..     398     459 ..     386     498 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8.2e-06
  DNA_topoisoIV 275 leklykktkLessisvnnlvlfdk.kpkylslkeilkeflevrlevyerrkeyllekleerleilegllkalnkidevievirkskkekkakkeLi 369
                     +++y  ++++++++v+ l  +d+ ++k+ ++ + ++ f+  ++++yer++  l +k+  r  + +      +++  ++++i ++ +  k +k+L 
     EFC38062.1 105 GNEIYVGFSCKTYLTVHILDTIDGsQKKQFTVDKGMNTFILKQMKYYERKLYLLFHKCGTRNIVHH------SNLFMIVDLITEKTQPIKLEKTLS 194
                    57889999****************88*******************************999877666......888888888888877666666665 PP

  DNA_topoisoIV 370 ee 371
                    + 
     EFC38062.1 195 TI 196
                    54 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.073
  DNA_topoisoIV 257 r.gvrivielkrgaseekvleklykktkLessisvnnlvlfdkk.pkylslkeilkeflevr 316
                    + ++ + + ++++ ++++ +ek+++ ++  s++s+   v+ + + + + + + i ke le  
     EFC38062.1 398 NdDFPVHLLYQTNDENNQHEEKVMSLLEFLSRLSLAEHVILNTGfEYFINFEMICKELLEKN 459
                    44555555566666677777778888888888888888888886477778888877777654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (535 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       987  (0.0550505); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 3160.67
//
Query:       EFC38063.1  [L=1340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.1e-07   30.6  56.4     0.0066   16.8  11.0    4.7  4  EGF_2          EGF-like domain
  ------ inclusion threshold ------
       0.01   15.4   0.6       0.13   11.9   0.3    3.2  3  DUF295         Protein of unknown function (DUF295)
      0.016   15.2   0.0      0.016   15.2   0.0    4.5  5  DUF5074        Domain of unknown function (DUF5074)
       0.61    9.8  10.9      0.028   14.2   2.4    2.7  2  Lipoprotein_X  Mycoplasma MG185/MG260 protein


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8  11.0   1.5e-06    0.0066       6      32 .]     706     731 ..     699     731 .. 0.86
   2 !   15.4   8.4   4.2e-06     0.019       5      32 .]     744     770 ..     739     770 .. 0.88
   3 ?    4.1   1.3     0.013        60      22      32 .]    1117    1127 ..    1117    1127 .. 0.96
   4 !   11.7  12.5   5.8e-05      0.26       5      32 .]    1140    1165 ..    1137    1165 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.5e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ +G+C + + +C C+ g++G+ C
  EFC38063.1 706 NACSKNGKCTSNN-VCTCNLGWTGAEC 731
                 68*******8555.9************ PP

  == domain 2  score: 15.4 bits;  conditional E-value: 4.2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G+C  +   C+C +g+ G +C
  EFC38063.1 744 SNVCSGRGSCQGLD-TCKCLDGFRGRNC 770
                 789********666.8***********9 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.013
       EGF_2   22 dCdsgyqGktC 32  
                  +C+s+y+G++C
  EFC38063.1 1117 YCPSSYFGPQC 1127
                  6********** PP

  == domain 4  score: 11.7 bits;  conditional E-value: 5.8e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g+G+C      C+C+++y G +C
  EFC38063.1 1140 TNVCSGNGICS--YSYCYCNQNYKGSNC 1165
                  579*******9..766************ PP

>> DUF295  Protein of unknown function (DUF295)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       2.2     1e+04      34      39 ..     597     601 ..     595     613 .. 0.69
   2 ?   11.9   0.3   2.8e-05      0.13      17      41 ..     633     658 ..     626     679 .. 0.79
   3 ?   -2.9   0.0       1.2   5.3e+03       9      21 ..     994    1009 ..     993    1015 .. 0.67

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.2
      DUF295  34 IYFttd 39 
                 IYFt d
  EFC38063.1 597 IYFT-D 601
                 9**5.4 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 2.8e-05
      DUF295  17 ssfsvsasdf.gglkgNcIYFttddd 41 
                 ss+s+sas +  ++k N IYF++d+ 
  EFC38063.1 633 SSLSLSASSCvLSVKNNVIYFVEDKS 658
                 799*******977********65443 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 1.2
      DUF295    9 raLFlGrn...ssfsv 21  
                  + LF+ ++   ssfsv
  EFC38063.1  994 QTLFVEDSwisSSFSV 1009
                  689**99944345555 PP

>> DUF5074  Domain of unknown function (DUF5074)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.21   9.2e+02      13      31 ..     118     136 ..      93     152 .. 0.82
   2 ?   -1.9   0.2      0.73   3.3e+03      53      81 ..     427     452 ..     387     465 .. 0.63
   3 ?   -3.6   0.0       2.5   1.1e+04      53      64 ..     537     548 ..     529     565 .. 0.69
   4 ?   15.2   0.0   3.6e-06     0.016       4      65 ..     592     658 ..     589     695 .. 0.81
   5 ?   -3.4   0.3       2.2   9.7e+03      63      76 ..     794     803 ..     768     841 .. 0.47

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.21
     DUF5074  13 sgtkLvkinpktlevktve 31 
                 ++++L+k+n ktl+++ ++
  EFC38063.1 118 HNAQLLKLNIKTLTTERLA 136
                 6789**********99765 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.73
     DUF5074  53 ttenaLYfiggsswfsgkkiykydidtet 81 
                  ++  +Y+ +gs   ++++++k++ +++ 
  EFC38063.1 427 YKNGLIYLHEGS---YSSTLLKFNQTSSV 452
                 233344444444...77777777666555 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 2.5
     DUF5074  53 ttenaLYfiggs 64 
                 t +n +Yf+++s
  EFC38063.1 537 TRDNEMYFMETS 548
                 678999999998 PP

  == domain 4  score: 15.2 bits;  conditional E-value: 3.6e-06
     DUF5074   4 skDGnvWaasgtkLvkinpktlevktvelpe.....lsiesswyawtptslcasttenaLYfiggss 65 
                  + Gn++ + g+kL ki++++  ++t++         ++  s+ + +++s + s ++n++Yf++ +s
  EFC38063.1 592 DEYGNIYFTDGAKLRKIDQSDSRISTLTSSTsgyssDGTDLSSLSLSASSCVLSVKNNVIYFVEDKS 658
                 566****************9988888777665544467788899999999999**********9983 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 2.2
     DUF5074  63 gsswfsgkkiykyd 76 
                 ++       ++k++
  EFC38063.1 794 TE----PMVYVKFN 803
                 22....22333332 PP

>> Lipoprotein_X  Mycoplasma MG185/MG260 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   2.4   6.2e-06     0.028     104     163 ..     403     462 ..     352     483 .. 0.90
   2 ?   -1.1   1.5       0.3   1.3e+03      83     146 ..     783     847 ..     780     855 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 6.2e-06
  Lipoprotein_X 104 nlknkdsksyknlkkvfnklkeliksnglflnkggsYsSnfqkkHqlafsigStsgyskn 163
                     lkn+ s+  +n+ ++ + ++    +ngl++ ++gsYsS+++k+ q    +   +gy++ 
     EFC38063.1 403 DLKNEKSSCSNNIISAMDSINYMTYKNGLIYLHEGSYSSTLLKFNQTSSVVAKIAGYYYY 462
                    57899998999**********************************************985 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.3
  Lipoprotein_X  83 ggnydnffyikvkegraidysn.lknkdsksyknlkkvfnklkeliksnglflnk.ggsYsSnfqk 146
                    + ++d+ +y  ++    + +++ ++ + + ++++ ++ +n +++ i +n l+ ++    Ys +f +
     EFC38063.1 783 QTDQDEYVYRSTEPMVYVKFNTtYSRSVTLKMEQRSSYYNIIRSTIYKN-LTAAElTTVYSQKFIN 847
                    5678888998888888999999999999999999999999999999999.6666525555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       903  (0.0503653); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.90u 0.32s 00:00:01.22 Elapsed: 00:00:00.53
# Mc/sec: 7578.10
//
Query:       EFC38064.1  [L=559]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-07   30.3   2.3    2.6e-05   24.3   0.2    3.4  2  AAA_14    AAA domain
    6.2e-05   23.3   0.2     0.0015   18.8   0.1    2.7  2  AAA_22    AAA domain
  ------ inclusion threshold ------
      0.028   14.8   0.0       0.19   12.1   0.0    2.2  1  AAA_16    AAA ATPase domain
       0.14   12.7   0.0       0.36   11.4   0.0    1.8  1  AAA_18    AAA domain
        1.5    9.1   5.7        4.5    7.6   0.1    3.0  3  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   0.2   7.3e-09   2.6e-05       5     113 ..     115     264 ..     112     269 .. 0.65
   2 ?    0.9   0.1      0.12   4.3e+02      42      93 ..     467     515 ..     441     520 .. 0.61

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 7.3e-09
      AAA_14   5 lvitGaRrvGKTtllkqlikell.........vkkesilyinldderd................................kkladpekllelileklke 62 
                 ++itG  r+GKTt ++ l+  l                  i  + + +                                +                  
  EFC38064.1 115 VFITGFVRTGKTTTARYLFPYLHsihccrrfnY-------IGYEVQYLdiqdfpkheqeeeyyyanriirsfvgegatvvD-----------------C 189
                 789***************988779966444332.......43333322223333344444444444444444444444431.................0 PP

      AAA_14  63 ..................ekktylflDEiqev.pewekalkslvd.....egknldvivtGSnskllskeiatsl 113
                                   +k+ y++lDEiq + p+  ++lk++++     +++n+  i tGS ++ll +++++ l
  EFC38064.1 190 mqdstqynpiteylekrsDKMVYFVLDEIQLLsPTTLNYLKKVFKsptlkSSSNFLSIWTGSTQSLLFRKLREVL 264
                 33344444444445455569**********8758899999999997666444899************99988765 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.12
      AAA_14  42 rdkkladpekllelileklke..ekktylflDEiqevpewekalkslvdegknl 93 
                 + k++a    l++ + +   +  ++k  ++ DE + v+++ ka++++  +++++
  EFC38064.1 467 DHKQFAAV--LNNGLID---NsiQNKIEIIEDEEKLVKTIIKAIRHISSQSSDC 515
                 33322222..2333333...13345677999**************998877555 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   4.2e-07    0.0015       7     118 ..     114     235 ..     113     256 .. 0.70
   2 ?   -2.7   0.0       1.8   6.5e+03      70      85 ..     322     346 ..     304     361 .. 0.51

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 4.2e-07
      AAA_22   7 ilvvtGesGtGKTtllrrlleqldeeakaee.........erpevv.fvtlpsst..sskdllrellralglelka..erlsseellealeqalrarav 91 
                 ++++tG + tGKTt++r l+  l+      +          +++++   + p+ +  +    ++++ r +  e+ +     + +  ++ ++++l++r++
  EFC38064.1 114 HVFITGFVRTGKTTTARYLFPYLHS----IHccrrfnyigYEVQYLdIQDFPKHEqeEEYYYANRIIRSFVGEGATvvDCMQDSTQYNPITEYLEKRSD 208
                 689******************9953....2355345555544444443344444453444447777777777777778555556666777777887777 PP

      AAA_22  92 .ielliiDEaqhlrseealeeLrsllnl 118
                   + +++DE+q l s++ l++L++ ++ 
  EFC38064.1 209 kMVYFVLDEIQLL-SPTTLNYLKKVFKS 235
                 7889*********.********998774 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.8
      AAA_22  70 a.........erlsseellealeqa 85 
                 +         +++++++ +++l q+
  EFC38064.1 322 SyvdqiisqrKTKTLQQSISHLIQQ 346
                 3444444444444555555333333 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   5.4e-05      0.19      26     164 ..     114     238 ..     105     247 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.4e-05
      AAA_16  26 lvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysa.laqalareellrqlldeaesaeleawrekleeala..avpelagaeasrlle 121
                  v+++G   +GK++ +r l+  +  +        c+++     y+   +q+l+  + + + ++e+e     +++ ++ +++    +  +++ + s  ++
  EFC38064.1 114 HVFITGFVRTGKTTTARYLFP-YLHS-----IHCCRRF----NYIGyEVQYLDI-QDFPKHEQEEEY----YYANRIIRSFVgeGATVVDCMQDSTQYN 197
                 589999999999999999994.4434.....2334444....455546666644.777777777444....4444444444433335555666688888 PP

      AAA_16 122 llkrllallsrderplvlvlDdlqwadeaslqllaaLlrlles 164
                  +++ l++ s   + +++vlD++q + +++l+ l+  +++++ 
  EFC38064.1 198 PITEYLEKRSD--KMVYFVLDEIQLLSPTTLNYLKKVFKSPTL 238
                 88888866554..45*******************999998776 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   9.9e-05      0.36       1      19 [.     115     138 ..     115     217 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 9.9e-05
      AAA_18   1 IlltGtpGvGKttlakeL.....s 19 
                 +++tG  ++GKtt a++L     s
  EFC38064.1 115 VFITGFVRTGKTTTARYLfpylhS 138
                 79****************444431 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.1    0.0012       4.5      31      91 ..     154     212 ..     132     233 .. 0.84
   2 ?   -1.5   0.1      0.79   2.8e+03      52      84 ..     292     330 ..     272     353 .. 0.54
   3 ?    3.0   0.2     0.034   1.2e+02      41      76 ..     510     545 ..     479     555 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0012
                 HHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTST.TSSTS-HHHHHHHHHHHCSSSTTTTTTH CS
         RGS  31 wlaveefkkakeqeelkkkakeIyneylapssp.kelnidkklreelekrlekeqpsrklfe 91 
                 +l++++f k  eqee    a++I++ ++ ++++   +  d+   + ++++lek   s k+ +
  EFC38064.1 154 YLDIQDFPKH-EQEEEYYYANRIIRSFVGEGATvVDCMQDSTQYNPITEYLEK--RSDKMVY 212
                 89********.999999***********9999966677788889999999999..4444444 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.79
                 HHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS..........S CS
         RGS  52 eIyneylapsspkelnidkklreelekrleke..........q 84 
                 +I+++y+     k  ++d ++  ++++ le +          q
  EFC38064.1 292 AIFQNYI----MKRKFVDTQVLRTIKDSLEVHhcsyvdqiisQ 330
                 5666666....33334555555555555554433334443442 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.034
                 SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHH CS
         RGS  41 keqeelkkkakeIyneylapsspkelnidkklreel 76 
                 +++++ k+  +eI++ +++++  + + i +k+re +
  EFC38064.1 510 SQSSDCKTLYQEIVKYWCNNEPRNFIRIAEKIREVV 545
                 5678889999****999999999999****999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (559 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       904  (0.0504211); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 3042.88
//
Query:       EFC38065.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00033   19.6   0.1    0.00065   18.6   0.1    1.4  1  Centro_C10orf90  Centrosomal C10orf90
  ------ inclusion threshold ------
      0.092   12.6   0.1       0.16   11.8   0.1    1.3  1  PRMT5            PRMT5 arginine-N-methyltransferase


Domain annotation for each model (and alignments):
>> Centro_C10orf90  Centrosomal C10orf90
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.1   7.3e-08   0.00065     175     225 ..      48      97 ..      30     102 .. 0.91

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 7.3e-08
  Centro_C10orf90 175 dpdnkensvspdssdsrekvPlvFsScVhLrVSqqcpntiyYLDkSLsVpi 225
                      ++d ke+++   + ++ +kv  +F+  Vh++VS+q + + y  D  L+Vp+
       EFC38065.1  48 SMDLKERKFLKFKLNQ-KKVEESFVERVHVEVSHQLSHSLYRADHPLNVPV 97 
                      4688999999999999.*********************************7 PP

>> PRMT5  PRMT5 arginine-N-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   1.8e-05      0.16      31     117 ..      50     143 ..      38     160 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.8e-05
                 HHHCC-CCHHHHHHHHHHHHHHHHCTCCGTCC.........-EEEEEEES-TTSHHHHHHHHHHHHHCCCEEEEEEEES-HHHHHHHHHHHHHHT CS
       PRMT5  31 evFEkdkvKYelYeeAiekalsdlkkekkkks........ekklvilvvGaGRGplvdralkaleetkvtkvkivavEKnpnavvtLqkkvneek 117
                 +  E+   K++l ++ +e+ ++++++ + +++        ++ l + v+G     l+++ l   + ++++++ i+ +EKn+n  + +++k ++e+
  EFC38065.1  50 DLKERKFLKFKLNQKKVEESFVERVHVEVSHQlshslyraDHPLNVPVIGKAQNVLLTH-LAFDRFSQKSNLAIFNIEKNENHSLKISQKFSTEE 143
                 5567777888888888888888887777666677888888999*******999988765.33344444479***************999987776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       722  (0.04027); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 2588.76
//
Query:       EFC38066.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        8.8    6.8  73.6         20    5.7  17.6    4.9  4  Paramecium_SA  Paramecium surface antigen domain


Domain annotation for each model (and alignments):
>> Paramecium_SA  Paramecium surface antigen domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7  20.3     0.019   3.5e+02       5      62 ..      95     171 ..      91     175 .. 0.63
   2 ?    5.6  16.1    0.0012        21      14      62 ..     171     218 ..     165     219 .. 0.76
   3 ?    5.7  17.6    0.0011        20      14      60 ..     212     255 ..     204     262 .. 0.84
   4 ?    2.2  10.6     0.014   2.5e+02       3      43 ..     258     306 ..     256     314 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.019
  Paramecium_SA   5 aeCqaysst.......Ctvna...dgtgCvel....kaaCssyttqeqCkknk.tggkClwngsttaCvdkt....C 62 
                    ++C+ +  +       C  ++   +++ C++     +++C +y+++++C+k +  ++kC+  +s++ C++k+    C
     EFC38066.1  95 KKCKLVCVKfktekgkCLKHEmkdQEKVCIKHktegEGTCLEYKHSKSCEKYSkPTKKCIKHKSEKVCQKKKtekvC 171
                    55554444433345566665565555777776333346788888888887776677888888888888877655555 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0012
  Paramecium_SA  14 CtvnadgtgCvelkaaCssyttqeqCkknktggkClwngsttaCvdkt.C 62 
                    C   ++++ C + +++C +ytt+++C++  ++++ + ++  ++C++ + C
     EFC38066.1 171 CDEYTTKKVCTRHATECDQYTTKKKCETV-SSTDSYSKSG-KSCKNVKvC 218
                    555557789*******************9.5555565554.799988777 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0011
  Paramecium_SA  14 CtvnadgtgCvelkaaCssyttqeqCkknktggkClwngsttaCvdk 60 
                    C      + C + k+ C+ y++++ Ckk k+ +kC+  +++++C++ 
     EFC38066.1 212 CKN---VKVCAKEKKVCKHYKKEQVCKKHKKVSKCIKFKTEKKCIKH 255
                    444...569***************************99999***976 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.014
  Paramecium_SA   3 thaeCqaysst..Ctvnadg.tgCvel.....kaaCssyttqeqCkknk 43 
                    t+++C ++++   C+ +++g + C++      k+ C++y +++ C+k++
     EFC38066.1 258 TKKKCLKFKKLkkCIRKSKGkKVCIKHklvggKKVCKEYEKKKVCEKKA 306
                    7888988887666999885537899875666668999999999999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3408  (0.190083); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 1865.89
//
Query:       EFC38067.1  [L=413]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-10   40.4   0.4    8.7e-10   39.5   0.4    1.5  1  GFO_IDH_MocA    Oxidoreductase family, NAD-binding Rossmann f
    0.00012   22.1   0.0    0.00026   21.0   0.0    1.6  1  GFO_IDH_MocA_C  Oxidoreductase family, C-terminal alpha/beta 
  ------ inclusion threshold ------
      0.021   14.7   0.1      0.049   13.5   0.1    1.6  1  Pox_TAA1        Poxvirus trans-activator protein A1 C-termina


Domain annotation for each model (and alignments):
>> GFO_IDH_MocA  Oxidoreductase family, NAD-binding Rossmann fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.5   0.4   1.5e-13   8.7e-10      54     118 ..      29      93 ..       9      95 .. 0.89

  Alignments for each domain:
  == domain 1  score: 39.5 bits;  conditional E-value: 1.5e-13
                   HHHHHTCTTESEEEE-S-GGGHHHHHHHHHHTT-EEEEESSS-SSHHHHHHHHHHHHHHTS-EEE CS
  GFO_IDH_MocA  54 leelladpeidavivatpngtheelakaaleagkhvllEKPlattveeakelvelaekkgklvsv 118
                    +  l++++ +av++at  + h e a+a++  + ++llEKP+a + e++k++ +++e+++++++v
    EFC38067.1  29 KATFLDESHERAVVIATQDQYHVEPAIAFAHLKFNILLEKPMAVNEEDCKRITKAVEENNVKLAV 93 
                   55566666889**************************************************9988 PP

>> GFO_IDH_MocA_C  Oxidoreductase family, C-terminal alpha/beta domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   4.3e-08   0.00026       1      64 [.     107     172 ..     107     194 .. 0.91

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 4.3e-08
                     HHHHHTTTTSSEEEEEE.EEECBEEECHHHHCCGGSH.HCSTSHHHHTCHHHHHHHHHHHTSEEEE CS
  GFO_IDH_MocA_C   1 KelIengklGevvsvdv.wtldtragaeakkrwkrrk.kksgGvlgdlgiHdiDllqwLfGqppsv 64 
                     Kel+++g +G++  ++  + ++++++a + +r+k++  ++s+++l  +++HdiD   + + + ++v
      EFC38067.1 107 KELLKSGLIGNIINIQHlEPVGYFHYAHSYVRGKWANeNTSSPMLLAKSCHDIDWISYVMQPAKVV 172
                     9**********9999999******************9*******************9999887776 PP

>> Pox_TAA1  Poxvirus trans-activator protein A1 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   8.2e-06     0.049      28      59 ..     239     268 ..     232     272 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 8.2e-06
    Pox_TAA1  28 kvlevInelrnkeGvYGscffkenkksiqisL 59 
                  v +vIn+l+ ++  YG+c++++++++++ + 
  EFC38067.1 239 TVENVINSLKTNN--YGRCVYDSDNNVVDNQV 268
                 589******9998..***********998665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (413 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       857  (0.0477997); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2473.41
//
Query:       EFC38068.1  [L=588]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00026   21.2   2.6    0.00026   21.2   2.6    2.7  2  RGS            Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.046   13.4   3.3       0.11   12.2   3.3    1.6  1  Borrelia_orfA  Borrelia ORF-A


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   2.6   2.9e-08   0.00026       4      78 ..      17     136 ..      15     151 .. 0.92
   2 ?   -1.8   0.2      0.41   3.6e+03      88     115 ..     240     267 ..     228     270 .. 0.77

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 2.9e-08
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.............................................SHHHHHHHHHHHHHHHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkka.............................................keqeelkkkakeIyney 57 
                 + +++++ +++F e+l+++f +e ++F   ve + k                                              ++ + l+ kakeI++e+
  EFC38068.1  17 QAIQSKDFMNVFSEYLKERFGDEIIRFMRRVESYSKDyhdsdmhtfnqitsptsptlsvntstisttnvntkqqqrnerqlrRSLKHLVLKAKEIIDEF 115
                 567788899********************************************************************99998888999999******** PP

                 TSTTSTTSSTS-HHHHHHHHH CS
         RGS  58 lapsspkelnidkklreelek 78 
                 ++ +s++eln+   + +++ +
  EFC38068.1 116 VELESNSELNLGATVQSKTLE 136
                 ***********9998877655 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.41
                 TTTHHHHHHHHHHHHHHHHHHHHTSHHH CS
         RGS  88 klfeeaqeevfellekdsypkFlksely 115
                 +lf +a       l+ + ++ F kse+ 
  EFC38068.1 240 DLFGQAMLMASVDLKMSHFQSFSKSEFL 267
                 6666777777777888999999999875 PP

>> Borrelia_orfA  Borrelia ORF-A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   3.3   1.2e-05      0.11      81     226 ..      12     153 ..      10     162 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.2e-05
  Borrelia_orfA  81 eiyYklnyekkelykkineyfkekKedliekikkrvnnyikkelnknnsvkklecinniaknksneeekkksiekeqlk.kyikkkkkkskkslsi 175
                    +iyY +  + k+ ++  +ey+ke+ +d i ++ +rv++y+k+  +       ++ +n i++ +s     + s +++ ++  +++ k+++ ++   +
     EFC38068.1  12 LIYYEQAIQSKDFMNVFSEYLKERFGDEIIRFMRRVESYSKDYHDSD-----MHTFNQITSPTS----PTLSVNTSTIStTNVNTKQQQRNERQLR 98 
                    69***********************999*********9996655443.....333334333332....3333333333212333333333333222 PP

  Borrelia_orfA 176 ln...lni.kkdikiklikiikkeeiaieikklknkqktlkniLrnlkkaLeeek 226
                         l +  k+i  + ++   ++e ++    +++  +++ +iL+  ++ L+  +
     EFC38068.1  99 RSlkhLVLkAKEIIDEFVELESNSELNLGATVQSKTLEKWDSILTLFNNYLKDSG 153
                    2213444446777778888888888777788888888888888887777776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (588 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       956  (0.0533214); expected 358.6 (0.02)
Passed bias filter:                      480  (0.0267723); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.35s 00:00:01.08 Elapsed: 00:00:00.56
# Mc/sec: 3186.68
//
Query:       EFC38069.1  [L=282]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.8e-08   32.8   0.0    1.3e-07   31.4   0.0    1.7  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   0.0   7.3e-12   1.3e-07       1     233 []      22     271 ..      22     271 .. 0.57

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 7.3e-12
                    EEEEESTGCHHHHTHHHHHHHHHHHHHHCTT.....SEEEEEEEBSCTCHHHHHHHHH..........TTCEEEEECCHECSSSTTSSEEEEEECS CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxx..........xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos   1 ltwNvngqaspalgssrrsdrladlltayda.....DvlgLQEvdddelsriplllal..........ggflgasstsptgggggggnggavlsrf 81 
                    +t+Nv++  +p l +  r+  ++++l   +a     Dv+++QEv d +l++i+   +             +           +    +g+ +++r 
     EFC38069.1  22 VTFNVWF--AP-LMMKERMEGIMQML---MAreelpDVMCFQEVTDEALEFIASHELIrkeyylsdspNDY----------YTTVDPYGVLMAVRK 101
                    69*****..55.88888999999999...4455566****************9999878877665543222..........222445666666666 PP

                    TE..EEEEEEEEEETSSSSGCEEEEEEEEEEEEEEE.........................CCCHHGHHHHHHHHHHHHHHHHHHHHHTTSEEEEE CS
                    xx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  82 pl..tslfrrtfiefndlvaalrreplaakleqlni.........................ashrdhdlvrdlqllalllqvealnadrgapviva 150
                     l  +++                                                       s     +   +  +  +l+v+   ++  + ++++
     EFC38069.1 102 GLpvRRM----------------------------FyntlpsrmyraclsvelndgkesfcISTVHLESLASTDMRFKQLDVISEFQQAFDNAVLC 169
                    6654222............................022233333444444455556666663444444444445555555555555555555999* PP

                    EE-SSSTSGGGBSCGHHHHHHCTTTHHSSCESCETTTTTTTTTTTEB-B............................................... CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............................................... RF
  Exo_endo_phos 151 GDfNarpsdddsrvlrtrglalapapvglyllgggptptyvtraggsrl............................................... 199
                    GDfN+++            +++ p                        l                                               
     EFC38069.1 170 GDFNFDSERN-------YDEDYLPY-----------------------Lendylnnenwksytdiwkelkypsnelgktfdtsvntmlkgqkeelm 235
                    *****32222.......22222221.......................122222333333333444444444444444444444444444444445 PP

                    ..EEEEEEC.HHHCCEEEEEEECCHHEEC..TSSCSSSB CS
                    ..xxxxxxx.xxxxxxxxxxxxxxxxxxx..xxxxxxxx RF
  Exo_endo_phos 200 ..Drilasp.alalfrsgvlppplalvrr..ealtlSDH 233
                      Dr++ ++ ++++  ++ l  +    ++  +++ lSDH
     EFC38069.1 236 ryDRVMLKSkSWKPTFVELLGTSP---IQtnPDIFLSDH 271
                    559999999888888888876543...335689999999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (282 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       395  (0.0220313); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1674.39
//
Query:       EFC38070.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.3e-06   28.1   2.5       0.04   14.0   0.1    4.4  4  NHL        NHL repeat
    0.00067   19.0   0.0       0.13   11.5   0.0    2.8  3  Lactonase  Lactonase, 7-bladed beta-propeller
    0.00079   18.7   1.7       0.79    8.8   0.0    2.9  2  DUF5128    6-bladed beta-propeller
     0.0033   16.0   0.2     0.0042   15.7   0.2    1.2  1  Utp8       Utp8 family


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0   0.00069       3.1       4      28 .]      83     108 ..      80     108 .. 0.90
   2 ?    1.9   0.0     0.061   2.7e+02       1      13 [.     236     249 ..     236     250 .. 0.91
   3 ?    0.6   0.0      0.15   6.8e+02      19      26 ..     302     309 ..     300     321 .. 0.76
   4 !   14.0   0.1   8.9e-06      0.04      12      28 .]     354     370 ..     349     370 .. 0.92

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00069
                 EEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   4 PhGvavd.snGdiyVaDsenhrvqvF 28 
                 P +v ++  n  i+V+Ds n r+ vF
  EFC38070.1  83 PLDVKISyRNEIILVSDSVNGRIMVF 108
                 88999999999************988 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.061
                 BSSEEEEEEE.TTT CS
         NHL   1 fnyPhGvavd.snG 13 
                 f++P G+ ++ ++G
  EFC38070.1 236 FARPVGIDYNfNSG 249
                 89*******99987 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.15
                 ECCCTEEE CS
         NHL  19 Dsenhrvq 26 
                 D++nh v 
  EFC38070.1 302 DRNNHNVI 309
                 78888774 PP

  == domain 4  score: 14.0 bits;  conditional E-value: 8.9e-06
                 TTEEEEEECCCTEEEEE CS
         NHL  12 nGdiyVaDsenhrvqvF 28 
                 +G++++ Ds+n+rvq++
  EFC38070.1 354 TGELLIVDSHNNRVQIY 370
                 69*************98 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.12   5.4e+02     240     273 ..      77     110 ..      56     118 .. 0.63
   2 !   11.5   0.0   2.9e-05      0.13     245     285 ..     182     221 ..     153     230 .. 0.78
   3 !    3.6   0.0    0.0072        32      80     114 ..     288     322 ..     255     329 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.12
                 S-S---EEEEEE-TTSSEEEEEETSSTEEEEEEE CS
   Lactonase 240 ftgknsaaeIrlspdgkflyvSnRgadsiavfav 273
                  ++ n++ ++++s  ++ + vS+  +  i+vf++
  EFC38070.1  77 PEKMNAPLDVKISYRNEIILVSDSVNGRIMVFDL 110
                 3334555566666666666666666666666665 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 2.9e-05
                 -EEEEEE-TTSSEEEEEETSSTEEEEEEE-TTT--EEEEEE CS
   Lactonase 245 saaeIrlspdgkflyvSnRgadsiavfavdeadgtltlvee 285
                 ++ +I+ + +g+ ly++n  +d+i+v++  ++++ ++++++
  EFC38070.1 182 QCCAIKYETSGNTLYCCNSATDTIVVYSC-ANGSVVKKITQ 221
                 7899************************9.55555555544 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.0072
                 EEE.SSS-EEEEEE-TTSSEEEEEETTTTEEEEEE CS
   Lactonase  80 kvssegaspchlsvdedgkllavAnYsggsvsvfp 114
                 + ++  + pc   +d++++ +++ +Y+++s++vf+
  EFC38070.1 288 SEKTILDMPCAALIDRNNHNVIICSYGTSSMAVFN 322
                 4555567899***********************96 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.5   0.00038       1.7      57      87 ..      87     118 ..      76     225 .. 0.72
   2 !    8.8   0.0   0.00018      0.79      66     126 ..     309     370 ..     299     371 .] 0.83

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00038
     DUF5128  57 kikvvdkrifvlDsaknnlfvFd.kkGkfvrk 87 
                 ki + ++ i+v Ds + ++ vFd ++G +++ 
  EFC38070.1  87 KISYRNEIILVSDSVNGRIMVFDlNSGLYKSD 118
                 56666677777777777777777777776654 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00018
     DUF5128  66 fvlDsaknnlfvFdkkGkfvrkIgaqGeG.PgEYlqindfiidksnesIyildfmknkiltY 126
                 ++    ++ + vF+k+G f++  ga+G    + ++  ++  +++   ++ i+d+ +n++ +Y
  EFC38070.1 309 IICSYGTSSMAVFNKEGTFIKSFGARGRNeNNRFMDQTSCCLNEITGELLIVDSHNNRVQIY 370
                 55555567788****************761566**********************9999888 PP

>> Utp8  Utp8 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.2   9.4e-07    0.0042     136     265 ..      84     220 ..      19     239 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 9.4e-07
        Utp8 136 vsikisskkkqivvv.lenGsielldfelk.lleslksskknkklvetfiedeekelllvvskskkkvayklisl..edesskilelsstiledfkles 230
                 +++kis  ++ i+v    nG i ++d ++    +++ ++ +  ++v     d ek+  l+ s+ ++ + y l++l  +d+s +++ + +t +e f++ +
  EFC38070.1  84 LDVKISYRNEIILVSdSVNGRIMVFDLNSGlYKSDFFTELAPWQFVLEENYDGEKNEALICSTGNNYLKYDLLQLlkSDRSRRATPIWKTKFERFSCFQ 182
                 5899999999766654679*********995556678888888888888888788889999997779*********9999999***********99876 PP

        Utp8 231 ak.fcYq.fG.kLYqlkkdkkeisvyslpsfqlqktis 265
                 ++ + Y+ +G +LY+ ++++ +i vys ++ ++ k+i+
  EFC38070.1 183 CCaIKYEtSGnTLYCCNSATDTIVVYSCANGSVVKKIT 220
                 652679988857****************9988888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       896  (0.0499749); expected 358.6 (0.02)
Passed bias filter:                      564  (0.0314574); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2236.06
//
Query:       EFC38071.1  [L=568]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.08   13.0   3.2       0.23   11.5   3.2    1.8  1  Spore_III_AB  Stage III sporulation protein AB (spore_III_AB)
       0.19   12.0   1.6       0.64   10.3   1.6    2.0  1  DUF948        Bacterial protein of unknown function (DUF948)
        2.6    8.2  22.0      0.055   13.6   9.5    2.8  2  BRE1          BRE1 E3 ubiquitin ligase


Domain annotation for each model (and alignments):
>> Spore_III_AB  Stage III sporulation protein AB (spore_III_AB)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   3.2   3.9e-05      0.23     119     157 ..     316     354 ..     315     355 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 3.9e-05
                   --SHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXX CS
  Spore_III_AB 119 ysdregqlkalelaleeleeeieeareeakkkeklyrtl 157
                   y++ e+++k l+++++ lee+i +++++ +kk+k++  l
    EFC38071.1 316 YENDEQNEKVLKRYIKSLEEKINKLEKKIEKKSKIIENL 354
                   578899****************************98765 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   1.6   0.00011      0.64      24      84 ..     326     381 ..     323     403 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00011
      DUF948  24 lkktldeaaatieelekqvdpilkevedllakvnelledvneklekvdplteavadlgesv 84 
                 lk+ ++++++ i++lek++++ +k +e+l+++ n+     ++k+ +++ ++++ + ++e++
  EFC38071.1 326 LKRYIKSLEEKINKLEKKIEKKSKIIENLMENQNN-----SKKVSEIEYIIQQTKPIAENI 381
                 78999******************************.....888888888888888888776 PP

>> BRE1  BRE1 E3 ubiquitin ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   9.5   9.2e-06     0.055      32      86 ..     308     362 ..     293     368 .. 0.86
   2 ?   -0.8   4.6      0.27   1.6e+03      10      50 ..     510     550 ..     508     558 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 9.2e-06
        BRE1  32 kklrleaekakadqkyfaamrskdalenelkkLnkllsKsselieqLkelekefv 86 
                 +k+r   + +  +q  + ++r +++le +++kL k+++K+s++ie+L e +++ +
  EFC38071.1 308 EKKRKFDDYENDEQNEKVLKRYIKSLEEKINKLEKKIEKKSKIIENLMENQNNSK 362
                 4444456788999999*********************************888765 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.27
        BRE1  10 kafeelseqlskkvkeltileekklrleaekakadqkyfaa 50 
                 k f++ +++l+kk+++  +   + + ++++++  d++ f++
  EFC38071.1 510 KRFKKDRKNLEKKKTKNDDDDFEENEITKDINNSDNEKFEI 550
                 67899999999999999999999999999999999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (568 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2915  (0.162586); expected 358.6 (0.02)
Passed bias filter:                      533  (0.0297284); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 3512.92
//
Query:       EFC38072.1  [L=496]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      1e-05   25.2   0.0        2.8    7.8   0.0    4.4  4  RCC1_2        Regulator of chromosome condensation (RCC1) rep
  ------ inclusion threshold ------
      0.085   13.5   0.0       0.23   12.1   0.0    1.7  1  Inhibitor_I9  Peptidase inhibitor I9
       0.18   12.4   1.4        9.5    6.9   0.0    2.5  2  RCC1          Regulator of chromosome condensation (RCC1) rep


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0   0.00068         4      12      30 .]     223     241 ..     219     241 .. 0.88
   2 !    7.8   0.0   0.00047       2.8      14      28 ..     278     292 ..     277     294 .. 0.92
   3 ?    1.5   0.0     0.044   2.7e+02      11      25 ..     346     360 ..     343     367 .. 0.85
   4 ?    2.2   0.0     0.027   1.6e+02      12      24 ..     394     406 ..     393     409 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00068
      RCC1_2  12 caLtedGeVlcWGsNsdGQ 30 
                 ++Lt +G+++++G N + Q
  EFC38072.1 223 IFLTKSGKIYGYGENLYNQ 241
                 78************98877 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00047
      RCC1_2  14 LtedGeVlcWGsNsd 28 
                 +te+G++++ G Nsd
  EFC38072.1 278 ITENGKLYASGENSD 292
                 8************97 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.044
      RCC1_2  11 scaLtedGeVlcWGs 25 
                 s++Lt++ ++l++G 
  EFC38072.1 346 SIFLTREKKLLACGK 360
                 689***********5 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.027
      RCC1_2  12 caLtedGeVlcWG 24 
                 +++t +G+V+  G
  EFC38072.1 394 LVITKNGKVHVIG 406
                 79*******9877 PP

>> Inhibitor_I9  Peptidase inhibitor I9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   3.9e-05      0.23      34      59 ..     324     352 ..     288     354 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.9e-05
                   T.....--EEEEEEESSSSSEEEEEE-GG CS
  Inhibitor_I9  34 e...dsakagilysYkilfnGfavkltee 59 
                   +    ++k++i++ Y+i++nG +++lt e
    EFC38072.1 324 KcdiIDEKYEIEHVYQIGINGLSIFLTRE 352
                   1456789*******************987 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.3     0.013        78       1      17 [.     228     244 ..     228     256 .. 0.84
   2 ?    6.9   0.0    0.0016       9.5       1      20 [.     281     302 ..     281     320 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.013
                 TTEEEEEE--GGGTTSS CS
        RCC1   1 dGrVysWGrndyGqLGl 17 
                 +G++y+ G n y+qL l
  EFC38072.1 228 SGKIYGYGENLYNQLNL 244
                 59*************77 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0016
                 TTEEEEEE--GGGTTSS..SS- CS
        RCC1   1 dGrVysWGrndyGqLGl..gtt 20 
                 +G++y+ G n+++ LG+  g+t
  EFC38072.1 281 NGKLYASGENSDYNLGCseGKT 302
                 69**************955333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.27s 00:00:00.93 Elapsed: 00:00:00.57
# Mc/sec: 2643.45
//
Query:       EFC38073.1  [L=234]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.4e-11   43.6   0.0    5.1e-11   43.0   0.0    1.2  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d
    3.3e-05   24.5   2.5     0.0044   17.5   0.6    2.2  2  Metallophos    Calcineurin-like phosphoesterase


Domain annotation for each model (and alignments):
>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.0   0.0   5.7e-15   5.1e-11       1     152 [.      51     223 ..      51     231 .. 0.76

  Alignments for each domain:
  == domain 1  score: 43.0 bits;  conditional E-value: 5.7e-15
  Metallophos_2   1 MklaiiSDlHsnldaleavlealkevgvdaiihaGDl.eeeepevleellela.........pvlaVrGNnD...eev.veedvlreaaelgtdlp 82 
                    Mk++iiSD+Hs+ d l +++   ++   d ++h+GD+ +++ +  ++ ++e +          ++++  N+    +++  + +   ++ ++++d  
     EFC38073.1  51 MKFVIISDTHSAHDNL-ELP---DDG--DVLVHCGDFtNKGLFGEVNSFFEFLrdkcdgkfkYIIVIVDNCGndiKIHgTRFRSKWKFPPFMRDSL 140
                    **********544443.344...457..89*******88888878888888777778887765555544444433333666666667888888888 PP

  Metallophos_2  83 eeaelel.agekvlliHgdpl........gvkdalaellke.aeegsdvvvcGHtHvp...evekeggvlvvnPGsvgeprdg 152
                     ++++++ ++ ++ll H   +        +++ +l+el+++ +  + ++ ++GH H     + e e+++l+vn+ s+++  ++
     EFC38073.1 141 RKKDFDIpKDIDILLSHFPSDkgkldssrRASTELTELINSsHFTKLKIHCFGHVHASrghYYESETDRLFVNAASIKGDKKK 223
                    999999967777*****9877888888888888888888884444445**********998899999**********998555 PP

>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.6   4.9e-07    0.0044       1      62 [.      51      99 ..      51     117 .. 0.71
   2 !    7.1   0.1   0.00076       6.8     159     203 ..     148     197 ..     100     198 .. 0.71

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 4.9e-07
                 EEEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSSHHHHHHHHHHHHHHH CS
  Metallophos  1 lrilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrgdlekellellaalvk 62
                 +++++i+D+H      + +d l+l d      + d+++++GD+++ g + + ++ ++++l +
   EFC38073.1 51 MKFVIISDTH------SAHDNLELPD------DGDVLVHCGDFTNKGLFGE-VNSFFEFLRD 99
                 89********......5555555554......56*************5555.5555554443 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.00076
                  TCSEEEEEESSESSCSSSCSCCHHHHHHH.HHHTT.....ESEEEEESSSS CS
  Metallophos 159 kadwvivlgHsplyrgsgylfgdealedl.lkkyg.....vdlvisGHtHv 203
                  ++d++i+l+H p   g+ ++  + ++e l + ++      +++ ++GH+H 
   EFC38073.1 148 PKDIDILLSHFPSDKGKLDSSRRASTE-LtELINSshftkLKIHCFGHVHA 197
                  4569**********5555555555555.3344444567779*********6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (234 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       424  (0.0236488); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1445.84
//
Query:       EFC38074.1  [L=309]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.1e-52  176.0  34.4    6.1e-52  176.0  34.4    2.0  2  DDRGK       DDRGK domain
     0.0088   15.5  36.5      0.013   14.9  36.5    1.4  1  Nop53       Nop53 (60S ribosomal biogenesis)
  ------ inclusion threshold ------
      0.011   15.8   0.1        0.9    9.7   0.0    2.8  2  FeoC        FeoC like transcriptional regulator
      0.021   15.1   1.5      0.021   15.1   1.5    2.9  2  DUF755      Domain of unknown function (DUF755)
      0.062   12.9   0.3        1.3    8.7   0.0    2.5  2  HTH_24      Winged helix-turn-helix DNA-binding


Domain annotation for each model (and alignments):
>> DDRGK  DDRGK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   3.9       0.2   7.2e+02      20      57 ..      25      62 ..      18      97 .. 0.41
   2 !  176.0  34.4   1.7e-55   6.1e-52       3     188 .]     110     293 ..     108     293 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.2
                XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
       DDRGK 20 qreaeeeereerkkleekreeerkekeekeeekekkke 57
                q+++  e++++ +  ++++ ++   ++ ++++++++++
  EFC38074.1 25 QQIVAPEQHQDEEEHHHQQRRNIPAARGQIRRRKNAAA 62
                33333222222222222222222222222222222222 PP

  == domain 2  score: 176.0 bits;  conditional E-value: 1.7e-55
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.H CS
       DDRGK   3 lgekkkkkleeKekkrqqreaeeeereerkkleekreeerkekeekeeekekkkeeeerkkeeekerkeqeeyeklksefvveeegtekesaeeeek.l 100
                 ++ kk +k  +K++ ++qrea+ + ++erk + +k+   ++++e ++eeke++  e+er ++eeke+k+qeeye++++ f+v e+g+  +s+  +++ +
  EFC38074.1 110 VNLKKMEKRRQKQALKEQREAMVQAEKERKTQMKKK---MEDEELEREEKEAELREAERIQREEKEKKKQEEYEEWRHLFEVSEQGEGIDSDMTHNEsI 205
                 6789999**************999988887766665...889999999999999999***************************99876666554445* PP

                 HHHHHHHHHH-SEE-HHHHHHHH-S-HHHHHHHHHHHHHHSSS-EEE-TT--EEE---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
       DDRGK 101 leefinyikekKvvlleelavkfklktqevierikeLeeqgsltGvlDdrGkyiyitdeEleavakyikkkGrvsiselveesnklIs 188
                 l+efinyik++Kvv le+la++fk+kt+ +i+rik+Lee+g++tG+lDdrGk+iyi++eE+e+v+++i ++Gr+sis+l +esnklI+
  EFC38074.1 206 LSEFINYIKDHKVVVLEDLASEFKIKTEHCINRIKSLEEEGKITGLLDDRGKFIYISKEEIEKVKQFILQEGRISISDLRNESNKLIN 293
                 ***************************************************************************************7 PP

>> Nop53  Nop53 (60S ribosomal biogenesis)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9  36.5   3.6e-06     0.013     212     352 ..      34     178 ..      18     247 .. 0.63

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 3.6e-06
       Nop53 212 ekeeeklerkrekiaekaataeareeelseekde......gleeeeeeeeeeeeeeeeeeeesee..eeklnapvkkkpkrKTkaqRnkekrrkeeeke 302
                 ++eee+  ++r++i +++ ++  r++  ++ +++      ++++ ++e+++++++++ e++e++   ++kl+ +++++  +K +++R+k++ ++++e+ 
  EFC38074.1  34 QDEEEHHHQQRRNIPAARGQIRRRKNAAASASSStnddheSASSGSDESDDDGSDHDSEAGEEDIhiHSKLTRNERVN-LKKMEKRRQKQALKEQREAM 131
                 333333333333333333333333332222222222222222233333333333333333333336778888777765.88888888888888888888 PP

       Nop53 303 ekeekkekkkeaqlerlkeikkevaekekeraeaaearkkekrkkkaekk 352
                  ++ek+ k ++++  + +e+++e +e+e ++ae+ ++  +ek+kkk+ ++
  EFC38074.1 132 VQAEKERKTQMKKKMEDEELEREEKEAELREAERIQR--EEKEKKKQ-EE 178
                 8888887777777777777777776666666665332..33333332.22 PP

>> FeoC  FeoC like transcriptional regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0   0.00025       0.9       1      44 [.     205     248 ..     205     256 .. 0.85
   2 ?    3.0   0.0     0.031   1.1e+02       4      20 ..     268     284 ..     266     290 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00025
        FeoC   1 iLtelkeyleergrvslkeLsrhfkaspealeamLeqwvrkGrv 44 
                 iL+e  +y++ ++ v l++L+ +fk+++e     +  ++  G++
  EFC38074.1 205 ILSEFINYIKDHKVVVLEDLASEFKIKTEHCINRIKSLEEEGKI 248
                 6889999********************99877777777777776 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.031
        FeoC   4 elkeyleergrvslkeL 20 
                 ++k+++ ++gr+s+++L
  EFC38074.1 268 KVKQFILQEGRISISDL 284
                 79*************99 PP

>> DUF755  Domain of unknown function (DUF755)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   1.5   5.7e-06     0.021      71     121 ..      29      79 ..      12      83 .. 0.53
   2 ?  -11.7  20.0         5   1.8e+04      59     102 ..     102     145 ..      95     184 .. 0.58

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 5.7e-06
      DUF755  71 eqkkssqthkkkkkksrnvssrsakkksakkrkksssSSssssssssssse 121
                 + +++  +++++++++rn  + + + +++k+   s sSS +++ +s ss +
  EFC38074.1  29 APEQHQDEEEHHHQQRRNIPAARGQIRRRKNAAASASSSTNDDHESASSGS 79 
                 333444444555555555555555555555556666777666666666544 PP

  == domain 2  score: -11.7 bits;  conditional E-value: 5
      DUF755  59 qqlqqkkqkkrkeqkkssqthkkkkkksrnvssrsakkksakkr 102
                 ++l+++++ + k+ +k  q++  k++++  v++++++k + kk+
  EFC38074.1 102 SKLTRNERVNLKKMEKRRQKQALKEQREAMVQAEKERKTQMKKK 145
                 45544444455555555555555555555555555555555555 PP

>> HTH_24  Winged helix-turn-helix DNA-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0   0.00036       1.3      22      48 .]     223     249 ..     210     249 .. 0.88
   2 ?    1.8   0.1      0.05   1.8e+02      12      27 ..     273     288 ..     271     290 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00036
      HTH_24  22 eLAerlglSpstvnrrlkrLeeeGlIk 48 
                 +LA +  +    +  r+k LeeeG I+
  EFC38074.1 223 DLASEFKIKTEHCINRIKSLEEEGKIT 249
                 899999999999************996 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.05
      HTH_24  12 LqknprisqreLAerl 27 
                 + +++ris+++L  ++
  EFC38074.1 273 ILQEGRISISDLRNES 288
                 7889*******97665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3890  (0.216967); expected 358.6 (0.02)
Passed bias filter:                      769  (0.0428914); expected 358.6 (0.02)
Passed Vit filter:                       211  (0.0117686); expected 17.9 (0.001)
Passed Fwd filter:                        59  (0.00329076); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.08u 0.36s 00:00:01.44 Elapsed: 00:00:00.54
# Mc/sec: 1724.30
//
Query:       EFC38075.1  [L=526]
Description: hypothetical protein NAEGRDRAFT_53287 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    7.2e-07   29.4  40.0      0.078   13.4   2.1    8.8 10  LRR_4       Leucine Rich repeats (2 copies)
    0.00043   20.1   1.1     0.0011   18.8   0.1    2.2  2  F-box       F-box domain
     0.0016   18.3   0.0     0.0033   17.3   0.0    1.5  1  F-box-like  F-box-like
     0.0078   16.0  19.6       0.27   11.0   0.1    4.4  4  FTH         FTH domain
  ------ inclusion threshold ------
        2.6    8.9  23.7        4.8    8.1   0.4    8.4  8  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.7   0.00047       1.7      11      36 ..     161     185 ..     142     192 .. 0.80
   2 !    8.8   0.6   0.00061       2.2       2      31 ..     174     207 ..     173     214 .. 0.73
   3 ?    3.5   0.1     0.029     1e+02       1      33 [.     199     238 ..     199     254 .. 0.55
   4 !   10.1   0.4   0.00023      0.84       2      38 ..     229     271 ..     228     280 .. 0.84
   5 ?   -1.1   0.0      0.84     3e+03      22      31 ..     285     294 ..     272     305 .. 0.71
   6 !   13.4   2.1   2.2e-05     0.078       1      33 [.     311     349 ..     311     357 .. 0.80
   7 !   10.6   0.6   0.00017      0.61       2      33 ..     371     400 ..     370     411 .. 0.85
   8 ?    4.6   1.1     0.013        48      19      31 ..     416     427 ..     404     441 .. 0.80
   9 ?    2.6   2.8     0.055     2e+02       2      41 ..     420     458 ..     419     476 .. 0.72
  10 ?    1.4   0.4      0.13   4.7e+02       2      18 ..     444     461 ..     443     494 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00047
                 S---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4  11 NqltdiplleklpnLkeLdLsgNnli 36 
                 N  ++i   ++l nL++LdLs+  ++
  EFC38075.1 161 NTFKSIAKSRNLVNLQTLDLSDH-KL 185
                 67788888889*********887.44 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00061
                 S--EEE--.SS---E-S-.....HHH-TT--EEE-. CS
       LRR_4   2 nLevLdLs.nNqltdipl.....leklpnLkeLdLs 31 
                 nL++LdLs + +l++        ++  pnL+eL L 
  EFC38075.1 174 NLQTLDLSdH-KLSKTAIghvkkFQ-VPNLTELKLC 207
                 9*******77.88875555544455.999*999984 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.029
                 SS--EEE--SS---E-S-...HH.....H.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl...le.....k.lpnLkeLdLsgN 33 
                 pnL++L L    ++++      +     k + n k+L+Ls+ 
  EFC38075.1 199 PNLTELKLCK--MKKFTEkevAKelfhsKfMSNIKKLYLSHS 238
                 5666666664..333222222113334577999999999774 PP

  == domain 4  score: 10.1 bits;  conditional E-value: 0.00023
                 S--EEE--SS-........--E-S-HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNq........ltdiplleklpnLkeLdLsgNnlitd 38 
                 n ++L+Ls+          + +i+  + + + ++L++ +N++i++
  EFC38075.1 229 NIKKLYLSH-SfegssksfIESISESKYMNQITHLNI-NNTYIDK 271
                 789999998.446777778999999999*********.9989976 PP

  == domain 5  score: -1.1 bits;  conditional E-value: 0.84
                 -TT--EEE-. CS
       LRR_4  22 lpnLkeLdLs 31 
                   nL++L + 
  EFC38075.1 285 KINLEHLEME 294
                 5689999884 PP

  == domain 6  score: 13.4 bits;  conditional E-value: 2.2e-05
                 SS--EEE--SS---E-S-....HH.H-TT--EEE...-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl....le.klpnLkeLd...LsgN 33 
                 +nL++L++sn+ ++  ++    l+ +lp+L++L    L  N
  EFC38075.1 311 KNLTYLNISNCFVSNQEFvdliLSpNLPKLTTLKakrL--N 349
                 79************999988663367*******86666..3 PP

  == domain 7  score: 10.6 bits;  conditional E-value: 0.00017
                 S--EEE--SS---E-S-.HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpnLkeLdLsgN 33 
                 +L++LdL++  lt +p  +  +p+Lk+L+ s++
  EFC38075.1 371 SLTELDLGD--LT-LPKlFDHCPKLKKLSFSDF 400
                 7********..**.9996667*******99775 PP

  == domain 8  score: 4.6 bits;  conditional E-value: 0.013
                 HHH-TT--EEE-. CS
       LRR_4  19 leklpnLkeLdLs 31 
                 ++ l nL++Ld++
  EFC38075.1 416 PN-LSNLEYLDIN 427
                 55.********94 PP

  == domain 9  score: 2.6 bits;  conditional E-value: 0.055
                 S--EEE--S......S---E-S-HHH-TT--EEE-.-S-----GGG CS
       LRR_4   2 nLevLdLsn......NqltdiplleklpnLkeLdLsgNnlitdlde 41 
                 nLe+Ld+++      N  t  p      nLkeL+L    +i ++++
  EFC38075.1 420 NLEYLDINHwkgmseNLFTN-PI---YSNLKELYL--T-PIHQVEP 458
                 88889998875666566663.33...689999999..3.5555544 PP

  == domain 10  score: 1.4 bits;  conditional E-value: 0.13
                 S--EEE--..SS---E-S- CS
       LRR_4   2 nLevLdLs..nNqltdipl 18 
                 nL++L+L   + q+  ++ 
  EFC38075.1 444 NLKELYLTpiH-QVEPLDV 461
                 55555555444.4444444 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   3.1e-07    0.0011       2      42 ..      90     131 ..      89     134 .. 0.93
   2 ?   -2.4   0.1       1.4     5e+03      22      40 ..     469     487 ..     462     490 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 3.1e-07
                 HHHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHHH CS
       F-box   2 tlsrLPsevlrhILerLplsd.llalrrVSkgwrilidsdrl 42 
                 ++ rL+ + l hI+++L++++    + +VSk w++ + +++ 
  EFC38075.1  90 SFTRLSADSLSHIFQFLDTTTlKNHCGLVSKLWNQSVEGLKV 131
                 689********************************9998875 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.4
                 HHHHHCTT-HHHHHHHTTH CS
       F-box  22 dllalrrVSkgwrilidsd 40 
                  l++l++ + +   ++ +d
  EFC38075.1 469 NLVNLAKLCIKSAHILTND 487
                 5899999997777777666 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   9.3e-07    0.0033       9      35 ..      99     126 ..      96     129 .. 0.92

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 9.3e-07
  F-box-like   9 LlqIFsyLppsdLlr.lalVCrrWrrva 35 
                 L++IF++L++++L + + lV++ W++ +
  EFC38075.1  99 LSHIFQFLDTTTLKNhCGLVSKLWNQSV 126
                 89**********************9866 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.1   7.7e-05      0.27       3      46 ..      71     113 ..      69     114 .. 0.91
   2 !    5.7   3.7    0.0034        12       4      81 ..     160     241 ..     157     262 .. 0.85
   3 ?    0.6   0.1      0.13   4.6e+02       9      50 ..     280     321 ..     275     336 .. 0.72
   4 !    7.5   0.8   0.00095       3.4      14      74 ..     387     449 ..     381     509 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 7.7e-05
         FTH   3 llealkkilkskkclkvkklsleglsfkdvasiLssfkagtLee 46 
                 ++ ++ ++lk+   ++ k++s+++ls + + +i++++++ tL++
  EFC38075.1  71 FIGNIHEFLKQ-VDIHRKQVSFTRLSADSLSHIFQFLDTTTLKN 113
                 67788889988.99****************************96 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0034
         FTH   4 lealkkilkskkclkvkklsleglsfk.dvasiLssfkagtLeeIel...sseeeeeefeelveleQWKnAkklkiesskls 81 
                  +++k+i ks + ++ ++l l++ +++  ++   + f+  +L e++l    ++ e e  +el++++   n kkl +++s+  
  EFC38075.1 160 ANTFKSIAKSRNLVNLQTLDLSDHKLSkTAIGHVKKFQVPNLTELKLckmKKFTEKEVAKELFHSKFMSNIKKLYLSHSFEG 241
                 5799*********************98678899**************7776777777889999999999****999988763 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.13
         FTH   9 kilkskkclkvkklsleglsfkdvasiLssfkagtLeeIel..s 50 
                 k+lk+  +++ ++l++e+++++   ++L s + ++L  +++  +
  EFC38075.1 280 KFLKD--KINLEHLEMEFYRLSVHPNLLTSGNYKNLTYLNIsnC 321
                 55555..7888888888888888999999999999999998432 PP

  == domain 4  score: 7.5 bits;  conditional E-value: 0.00095
         FTH  14 kkclkvkklsleglsfk.dvasiLssfkagtLeeIel...sseeeeeefeelveleQWKnAkklk 74 
                 ++c k kkls+++++ + + ++iL ++k+ +L ++e     +     ++e+l+    + n k+l 
  EFC38075.1 387 DHCPKLKKLSFSDFDDDdNNKEILNMMKSPNLSNLEYldiNH--WKGMSENLFTNPIYSNLKELY 449
                 5899**********9974678888888888888887753233..344456666666666666665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0      0.03   1.1e+02       1      12 [.     174     185 ..     174     206 .. 0.81
   2 ?    1.2   0.0      0.25   8.9e+02       1      12 [.     229     240 ..     229     251 .. 0.74
   3 ?   -0.0   0.0      0.63   2.3e+03       3      12 ..     260     269 ..     258     280 .. 0.79
   4 ?    0.1   0.1      0.58   2.1e+03       1      12 [.     287     298 ..     287     307 .. 0.72
   5 ?    8.1   0.4    0.0013       4.8       1      12 [.     312     323 ..     312     340 .. 0.76
   6 ?    0.6   0.1      0.39   1.4e+03       1      10 [.     371     389 ..     371     401 .. 0.60
   7 ?    1.7   0.0      0.17   6.2e+02       1       9 [.     420     428 ..     420     438 .. 0.88
   8 ?    0.7   0.7      0.38   1.4e+03       1      12 [.     444     469 ..     444     492 .. 0.67

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.03
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++LdLs+  l
  EFC38075.1 174 NLQTLDLSDHKL 185
                 8******99877 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.25
       LRR_1   1 nLrhLdLsnnpl 12 
                 n ++L+Ls+ + 
  EFC38075.1 229 NIKKLYLSHSFE 240
                 789*****9984 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.63
       LRR_1   3 rhLdLsnnpl 12 
                 +hL+++n  +
  EFC38075.1 260 THLNINNTYI 269
                 8****99776 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.58
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+hL ++  +l
  EFC38075.1 287 NLEHLEMEFYRL 298
                 8****9987666 PP

  == domain 5  score: 8.1 bits;  conditional E-value: 0.0013
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L++sn++ 
  EFC38075.1 312 NLTYLNISNCFV 323
                 8*********95 PP

  == domain 6  score: 0.6 bits;  conditional E-value: 0.39
       LRR_1   1 nLrhLdL.........snn 10 
                 +L++LdL          ++
  EFC38075.1 371 SLTELDLgdltlpklfDHC 389
                 6999999333333333444 PP

  == domain 7  score: 1.7 bits;  conditional E-value: 0.17
       LRR_1   1 nLrhLdLsn 9  
                 nL++Ld+++
  EFC38075.1 420 NLEYLDINH 428
                 8******76 PP

  == domain 8  score: 0.7 bits;  conditional E-value: 0.38
       LRR_1   1 nLrhLdL..............snnpl 12 
                 nL++L+L              sn+ +
  EFC38075.1 444 NLKELYLtpihqvepldvnlvSNCTN 469
                 89999986666555555555566654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (526 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       952  (0.0530983); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.36s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 2873.93
//
Query:       EFC38076.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00012   21.8   0.1    0.00017   21.3   0.1    1.3  1  AKAP28    28 kDa A-kinase anchor
  ------ inclusion threshold ------
       0.06   13.5   0.1       0.28   11.3   0.0    1.9  2  DUF4825   Domain of unknown function (DUF4825)


Domain annotation for each model (and alignments):
>> AKAP28  28 kDa A-kinase anchor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.1   1.9e-08   0.00017      29      79 ..      36      86 ..      12     117 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 1.9e-08
      AKAP28 29 wlyliefleekeaekskiyiyrvrwSiptrrkPipratasvyFtikvskik 79
                +++  e le++++  ++   yrv+ S pt+++Pip ++ +++ +++  + k
  EFC38076.1 36 YVFKREELEKESTPLERKVSYRVTISNPTKQNPIPSIVYYIRVIFRAPSSK 86
                77888999*****************************99888777764443 PP

>> DUF4825  Domain of unknown function (DUF4825)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.13   1.1e+03      32      52 ..      40      60 ..       7      70 .. 0.67
   2 ?   11.3   0.0   3.1e-05      0.28      13      69 ..      85     138 ..      83     141 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.13
     DUF4825 32 gieLqtekePYgltvnyeeke 52
                  eL++e++P + +v y  + 
  EFC38076.1 40 REELEKESTPLERKVSYRVTI 60
                346666666666666665554 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 3.1e-05
     DUF4825  13 savgkilkaLplpeglsydgieLqtekePYgltvnyeeketekeeeelkeelkknav 69 
                 s+v k l++Lp+ ++++   +  + +keP++l +n+ee   +   e++k+e+   a 
  EFC38076.1  85 SKVLKHLETLPFVQHVQ---FFVEHRKEPFELALNIEEGLMSTPRETIKQEFDFIAL 138
                 89999999999999886...999****************999999999999987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 918.29
//
Query:       EFC38077.1  [L=327]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-10   42.1   8.4    1.2e-10   42.1   8.4    2.6  2  Hep_59    Hepatocellular carcinoma-associated antigen 59


Domain annotation for each model (and alignments):
>> Hep_59  Hepatocellular carcinoma-associated antigen 59
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   7.5     0.043   7.6e+02      29      97 ..      37     116 ..       3     124 .. 0.58
   2 !   42.1   8.4   6.6e-15   1.2e-10       5     106 .]     171     298 ..     168     298 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.043
      Hep_59  29 kskqeqeeeeekeseassksedaedelyevpehlkv...sskkeeeea...........lsnqmlggIpEVdLgieaklkNie 97 
                 +++++q+ee+ +e+++s++  + e+e  + +e+l+    +++++                 + m++ +   dL +  k+kN +
  EFC38077.1  37 SDQNNQQEEQTNENTTSASITTGEPEQITSSERLEEdgdNINET---LektilkqklrsRPKGMQANLKTGDLFDLDKIKNSS 116
                 24555555555555566666666666444555554433211111...111233333444556888888888888888888865 PP

  == domain 2  score: 42.1 bits;  conditional E-value: 6.6e-15
      Hep_59   5 qtgkrdvdkhMekYIeeeLakrkgk...skqeqeeeeekeseassksedaede......lyevpehlkv........sskkeeeea...........ls 75 
                 + +  ++dk + ++I+e+++++  +     ++++e+e+ e+++++ s d ++       ly++p++lkv        +   +++++           + 
  EFC38077.1 171 EAELSEQDKRLFEFIKERMKEQGYSydqIVNNDDEDEGIEKAKKKISVDINELlekeknLYKLPDELKVekidisslT---RRKDNankeakplteeER 266
                 457788***************44337775566666777777777777777666778888**********999885441...333334556799998644 PP

      Hep_59  76 nqml.ggIpEVdLgieaklkNieetekakrkl 106
                 +++l g+I EV+L++ ak++Ni+et+++ ++l
  EFC38077.1 267 QKLLsGAILEVPLSTAAKVENIRETNEKVKEL 298
                 4444699*******************998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (327 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2622  (0.146244); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 1893.38
//
Query:       EFC38078.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.1e-43  147.0   0.4    2.6e-41  141.7   0.0    2.0  2  Epimerase        NAD dependent epimerase/dehydratase family
    5.6e-14   52.3   0.0    1.1e-13   51.3   0.0    1.5  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    4.6e-06   25.8   0.0    8.3e-06   25.0   0.0    1.4  2  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
    9.4e-06   25.0   0.3    0.00094   18.4   0.0    3.0  2  Polysacc_synt_2  Polysaccharide biosynthesis protein


Domain annotation for each model (and alignments):
>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.7     0.011        48       1      14 [.      24      37 ..      24      39 .. 0.91
   2 !  141.7   0.0   5.8e-45   2.6e-41      46     232 ..      39     237 ..      37     244 .. 0.95

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.011
                EEEETTTSHHHHHH CS
   Epimerase  1 ilVtGatGfiGsal 14
                +lVtG+tG+ G+a+
  EFC38078.1 24 VLVTGGTGLFGKAV 37
                79*********986 PP

  == domain 2  score: 141.7 bits;  conditional E-value: 5.8e-45
                 EE--TT-HHHHHHHHHHHT-SEEEE--S.---HHHHHHSHHHHHHHHTHHHHHHHHHHHHHTCTEEEEEEEGGGGTSCSSSS.BSTCSTTS--.--SSH CS
   Epimerase  46 veldltdrsalerlfkeeqpdavihlAa.vggvaassedpadfieknlqgtlnlleaarkagvkrllflsSsevYGkdaeqp.keettltgpl.kpnsp 141
                 +++dl+d sa+++lf++++p++v+hlAa vgg   +++ +  f+ +n++++ n+l+++ ++gvk+ + + S++v++++ e p +e+++++gp   +n++
  EFC38078.1  39 HDGDLRDLSACKALFEKYKPTYVLHLAAfVGGLFKNMNFKVSFWLDNVNMNNNILSCCYEYGVKKTISCLSTCVFPDKIEYPiTEDKLHEGPPhFSNNA 137
                 789*****************************************************************************9989*********99**** PP

                 HHHHHHHHHHHHHHHHHHHT.....-EEEEEEESEEESTT.S-TTSTTSHHHHHHHHHHTTS...SSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT CS
   Epimerase 142 YaaaKlageklveayaaqyg.....lnaiilrlfnlyGpr.ngegevsrvipalirkilegk...qevtllgdgtalRdflyveDvaeaillvlehvda 231
                 Ya+aK++ + l   y++q        ++ +++++nlyGp+ n++ e+ +v+p l+ k+++++    +++++g+g++lR+fl++ D+a+++l+ + ++++
  EFC38078.1 138 YAYAKRMLDMLSVWYNEQAVregkeSRFSSVIPTNLYGPHdNFNVENGHVLPGLMHKCYKAQkegSDFIVYGSGKPLRQFLFSHDAARMLLWTMLNYQS 236
                 ***********99999998557888***********************************776677***************************999877 PP

                 - CS
   Epimerase 232 g 232
                 +
  EFC38078.1 237 Q 237
                 4 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1       0.4   1.8e+03       1      11 [.      25      35 ..      25      40 .. 0.87
   2 !   51.3   0.0   2.5e-17   1.1e-13      57     261 ..      39     258 ..      33     305 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.4
                   EEETTTSHHHH CS
  GDP_Man_Dehyd  1 LiTGiaGfiGs 11
                   L+TG++G  G 
     EFC38078.1 25 LVTGGTGLFGK 35
                   9******9886 PP

  == domain 2  score: 51.3 bits;  conditional E-value: 2.5e-17
                    EE--TT-HHHHHHHHHHHT-SEEEE--S---.HHHHTTSHHHHHHHHTHHHHHHHHHHHHCT..TTSEEEEEEEGGGG-S-SSSSB-TT.....S- CS
  GDP_Man_Dehyd  57 hkgDltDssslerllaevqpdevynLAAqsh.VdvsfekPeytaevnvlGtlrLLeairalglekkvrfyqaStsEvYGkvqevpqtEt.....tp 146
                    h gDl+D s+ + l+++++p+ v++LAA      + ++    ++  nv    ++L ++ ++g++k++     St  v+ +  e p+tE+      p
     EFC38078.1  39 HDGDLRDLSACKALFEKYKPTYVLHLAAFVGgLFKNMNFKVSFWLDNVNMNNNILSCCYEYGVKKTIS--CLST-CVFPDKIEYPITEDklhegPP 131
                    89**************************8543677777778999999***************975444..3444.69****999999983333345 PP

                    ----SHHHHHHHHHHHHHHHHHHH.....H---EEEEEE-EEESTTS-TTS....CCCHHHHHHHHHHTTS-C-EECTTTT-EEEEEEHHHHHHH. CS
  GDP_Man_Dehyd 147 fyPrsPYaaaKlyadwivvnyrea.....yglfavngilfnhesprrgetf....vtrkitravarialgkqevlylGnldakRdwghvkDyvea. 232
                       ++ Ya aK + d++ v y+e+      +   ++ i  n ++p+ + ++    v   +++   +++++  + +++G +++ R +++ +D +++ 
     EFC38078.1 132 HFSNNAYAYAKRMLDMLSVWYNEQavregKESRFSSVIPTNLYGPHDNFNVenghVLPGLMHKCYKAQKEGSDFIVYGSGKPLRQFLFSHDAARMl 227
                    557******************8874444356689999*********877652222444455556666777789*********************97 PP

                    HHHHHHCSS---EE..E-TT-EEECHHCHHC CS
  GDP_Man_Dehyd 233 mwlmlqqdkpedyv..iatgethsvrefvel 261
                    +w+ml+ +++e ++  +++ ++ s++++++ 
     EFC38078.1 228 LWTMLNYQSQEPIMlcVSEEDEKSIGQVAQS 258
                    8****88777776611455556666666543 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1      0.47   2.1e+03       1      12 [.      25      36 ..      25      39 .. 0.88
   2 !   25.0   0.0   1.8e-09   8.3e-06      50     192 ..      39     184 ..      32     238 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.47
   3Beta_HSD  1 vvtGgaGFlGra 12
                +vtGg+G  G+a
  EFC38078.1 25 LVTGGTGLFGKA 36
                69*******987 PP

  == domain 2  score: 25.0 bits;  conditional E-value: 1.8e-09
   3Beta_HSD  50 iegDvtdkdkleealegvd..vvihlaslv.dvagklted.eimkvnvkGTrnvleacvkagvrvlvYtSsaevvgpnslgeeilngdEeleyeslhqd 144
                 + gD++d +  ++  e+ +   v+hla+ v  ++++++++ ++   nv+  +n+l+ c + gv++ + + s   v+p++ + +i++ + ++  ++  ++
  EFC38078.1  39 HDGDLRDLSACKALFEKYKptYVLHLAAFVgGLFKNMNFKvSFWLDNVNMNNNILSCCYEYGVKKTISCLST-CVFPDKIEYPITEDKLHEGPPHFSNN 136
                 6788888888888877765336888887652566666655244455777789***************99875.68999*******77766667777899 PP

   3Beta_HSD 145 aypesKalaEklvlkaNgrtlknggrlyTcaLRpagiyGegdkllvpl 192
                 ay++ K++ + l +  N++ +++g++    ++ p+ +yG+ d++ v+ 
  EFC38078.1 137 AYAYAKRMLDMLSVWYNEQAVREGKESRFSSVIPTNLYGPHDNFNVEN 184
                 *************************88889999********9987654 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.5     0.011        49       1      14 [.      24      37 ..      24      40 .. 0.91
   2 !   18.4   0.0   2.1e-07   0.00094      61     131 ..      41     117 ..      35     177 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.011
                     EEEETTTSHHHHHH CS
  Polysacc_synt_2  1 vlvtGagGsiGsel 14
                     vlvtG++G +G+++
       EFC38078.1 24 VLVTGGTGLFGKAV 37
                     89*********976 PP

  == domain 2  score: 18.4 bits;  conditional E-value: 2.1e-07
                      --TT-HHHHHHHTT..T-SEEEE------HHHHHHS.HHHHHHHHHHHHHHHHHHHHHTT-SEEE.EEEE....GGG CS
  Polysacc_synt_2  61 gdvrdkerlekaleelkvdvvfhaAAlKhVPlveen.pleaiktNvlgtenvieaaieagvkkvv.liSt....DKA 131
                      gd+rd + ++ ++e++k+ +v+h AA+      ++n  ++ +  Nv   +n+++++ e+gvkk + ++St    DK 
       EFC38078.1  41 GDLRDLSACKALFEKYKPTYVLHLAAFVGGLFKNMNfKVSFWLDNVNMNNNILSCCYEYGVKKTIsCLSTcvfpDKI 117
                      89************************97666655552578999*******************988467774444555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       573  (0.0319594); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 1945.44
//
Query:       EFC38079.1  [L=1237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1279  (0.0713369); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.25s 00:00:00.88 Elapsed: 00:00:00.41
# Mc/sec: 8957.37
//
Query:       EFC38080.1  [L=548]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0028   17.8  11.8      0.007   16.5  11.8    1.7  1  Zn_clus    Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
      0.034   14.9   1.3      0.089   13.6   0.1    2.3  2  KIAA1430   KIAA1430 homologue
       0.16   12.1   0.0        3.3    7.9   0.0    2.5  2  DUF2379    Protein of unknown function (DUF2379)


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5  11.8   1.2e-06     0.007       2      38 ..      89     124 ..      88     126 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1.2e-06
                 S-HHHHHCT---ST.SSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus   2 aCdnCrkkKvKCda.kkPaCsnCkklnleCtfysessk 38 
                 aC++Crk +  C++ k++ C +Ck ++  C+ ++es++
  EFC38080.1  89 ACIRCRKMHKFCSRhKTG-CERCKAKGIVCE-FRESKR 124
                 9*************6666.************.888876 PP

>> KIAA1430  KIAA1430 homologue
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       1.7     1e+04      74      84 ..     128     138 ..      93     154 .. 0.46
   2 ?   13.6   0.1   1.5e-05     0.089      23      65 ..     492     533 ..     469     545 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.7
    KIAA1430  74 askslnaenrk 84 
                 +s +l+ ++rk
  EFC38080.1 128 SSDNLEDKKRK 138
                 22223222222 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 1.5e-05
    KIAA1430  23 lskkkkklqleeerlkeiereNqiLleklseimrrkgkkksas 65 
                 l k  + l +  +r+k+i+  Nq+Ll+ ++ei ++++k ++a+
  EFC38080.1 492 LAKDYRALNVLGRRFKRIQVCNQKLLSTIAEILNNRNK-NDAN 533
                 5555566666679*********************9965.2222 PP

>> DUF2379  Protein of unknown function (DUF2379)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0     0.079   4.7e+02      11      63 ..     351     404 ..     345     407 .. 0.82
   2 ?    7.9   0.0   0.00055       3.3      49      92 ..     491     534 ..     483     545 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.079
     DUF2379  11 Larrvleeg..epleLtdevralLrrtarevaiseadaeeaLateesAlaLlrei 63 
                 L++ v++e+  + ++L +e+ +l+  + ++ a + + +e+ + t  +Al+ l++i
  EFC38080.1 351 LQEEVTQENcfNFIKLGEEMAKLIITSTKNRACK-QKTEKQMVTYDKALNFLQNI 404
                 66667666533468999**************998.78999999999999999976 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00055
     DUF2379  49 aLateesAlaLlreiarRiregskrLvdallrmlrlrdagDldg 92 
                  La +  Al+ l +  +Ri+   ++L +++ ++l+ r++ D + 
  EFC38080.1 491 ILAKDYRALNVLGRRFKRIQVCNQKLLSTIAEILNNRNKNDANV 534
                 689999**********************************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (548 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.28s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 3375.68
//
Query:       EFC38081.1  [L=1059]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1059 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1685  (0.0939818); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.17u 0.39s 00:00:01.56 Elapsed: 00:00:00.59
# Mc/sec: 5366.70
//
Query:       EFC38082.1  [L=400]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.2e-68  224.6  15.0    4.5e-16   58.3   0.0    7.8  9  DUF4116    Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.048   13.9   1.6          6    7.2   0.1    3.4  3  DUF3107    Protein of unknown function (DUF3107)
       0.13   12.5   0.3        8.3    6.7   0.0    2.7  2  DUF1611_N  Domain of unknown function (DUF1611_N) Rossmann-li
        2.4    8.3   8.9       0.15   12.1   1.3    2.9  3  DUF1154    Protein of unknown function (DUF1154)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.1    0.0075        33      16      38 ..      97     119 ..      92     125 .. 0.81
   2 !   16.2   0.0   1.4e-06    0.0064       1      49 []     107     156 ..     107     156 .. 0.87
   3 !   39.2   0.0   9.4e-14   4.2e-10       1      44 [.     133     176 ..     133     176 .. 0.98
   4 !   58.3   0.0     1e-19   4.5e-16       1      49 []     158     206 ..     158     206 .. 0.99
   5 !   44.9   0.0   1.6e-15   7.1e-12       1      49 []     208     258 ..     208     258 .. 0.96
   6 !   26.9   0.1   6.4e-10   2.9e-06      13      48 ..     247     283 ..     244     285 .. 0.91
   7 !   21.9   0.2   2.3e-08    0.0001       1      35 [.     260     295 ..     260     307 .. 0.90
   8 !   48.1   1.1   1.5e-16   6.8e-13       1      49 []     314     362 ..     314     362 .. 0.99
   9 !   22.5   0.5   1.6e-08     7e-05       1      33 [.     364     396 ..     364     399 .. 0.95

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0075
     DUF4116  16 lkylseeLknDkeivlkAvkqng 38 
                 + +l +eLk D +++ ++v +++
  EFC38082.1  97 YINLGKELKFDSNFIFQIVGISP 119
                 567889***********997766 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 1.4e-06
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D  ++ ++v +  g+++++ +e ++nD+e+vl+ vk  g+ ls as+ L+
  EFC38082.1 107 DSNFIFQIVGISpGFIYNNSNEVIRNDREVVLRSVKGVGSMLSIASDRLK 156
                 66788888885538999999999*************999***99999886 PP

  == domain 3  score: 39.2 bits;  conditional E-value: 9.4e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 DrE+vl  vk  gs l  +s++Lk D+eiv++Avkq+g +l+ya
  EFC38082.1 133 DREVVLRSVKGVGSMLSIASDRLKDDREIVMAAVKQDGGSLRYA 176
                 9*************************************999997 PP

  == domain 4  score: 58.3 bits;  conditional E-value: 1e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+ avk++g +l+y+++++k+D+e+vl Avk++g+al  ++e+Lr
  EFC38082.1 158 DREIVMAAVKQDGGSLRYANDRFKSDRELVLSAVKSSGHALQSVHESLR 206
                 9**********************************************98 PP

  == domain 5  score: 44.9 bits;  conditional E-value: 1.6e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng..talsyaseeLr 49 
                 DrEiv  a+++++s l  + ee+knD+eiv+kAv +n   +a+ yas eL+
  EFC38082.1 208 DREIVELAISHCWSFLGSAGEEMKNDREIVMKAVMRNEqgSAFQYASRELK 258
                 9**********************************988668*******997 PP

  == domain 6  score: 26.9 bits;  conditional E-value: 6.4e-10
     DUF4116  13 gsalkylseeLknDkeivlkAvkqng.talsyaseeL 48 
                 gsa++y+s eLk Dk +vl+ v++++ +al+ya eeL
  EFC38082.1 247 GSAFQYASRELKLDKKFVLEVVRKSKgFALEYALEEL 283
                 89*********************7666*******998 PP

  == domain 7  score: 21.9 bits;  conditional E-value: 2.3e-08
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvk 35 
                 D+ +vle+v+k  g+al+y+ eeL +D+e++ ++++
  EFC38082.1 260 DKKFVLEVVRKSkGFALEYALEELIKDREFLVEILE 295
                 999*******8889*****************99987 PP

  == domain 8  score: 48.1 bits;  conditional E-value: 1.5e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+++l   k +g+++ky++ee+k+Dkeiv +Av qn +++ +++++Lr
  EFC38082.1 314 DRDLILLTAKYDGFIIKYINEEFKKDKEIVFEAVSQNINVFQHIDKSLR 362
                 9**********************************************98 PP

  == domain 9  score: 22.5 bits;  conditional E-value: 1.6e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkA 33 
                 D+E+vl + +kn++++++l +++k+D e++ ++
  EFC38082.1 364 DKEFVLRLARKNSKIIQFLTKSMKKDHEFMSQI 396
                 9*****************************875 PP

>> DUF3107  Protein of unknown function (DUF3107)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.1   4.8e+03      11      34 ..     133     156 ..     129     173 .. 0.52
   2 ?    7.2   0.1    0.0013         6      10      42 ..     182     214 ..     180     218 .. 0.93
   3 ?    3.8   0.1     0.015        67      11      42 ..     339     371 ..     336     382 .. 0.73

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.1
     DUF3107  11 aRelvieseqsadeveaaveeala 34 
                  Re+v++s +    + +  ++ l+
  EFC38082.1 133 DREVVLRSVKGVGSMLSIASDRLK 156
                 566666665444333333333333 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0013
     DUF3107  10 saRelvieseqsadeveaaveealagdegvltL 42 
                 s Relv++  +s+ +  + v+e l++d ++++L
  EFC38082.1 182 SDRELVLSAVKSSGHALQSVHESLRNDREIVEL 214
                 78**************************99998 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.015
     DUF3107  11 aRelvieseqsadeveaaveealagdeg.vltL 42 
                  +e+v+e  +++ +v +++++ l++d++ vl+L
  EFC38082.1 339 DKEIVFEAVSQNINVFQHIDKSLRDDKEfVLRL 371
                 689*********************443314444 PP

>> DUF1611_N  Domain of unknown function (DUF1611_N) Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.1     0.046   2.1e+02      48      83 ..     182     217 ..     174     221 .. 0.86
   2 ?    6.7   0.0    0.0018       8.3      48      90 ..     338     380 ..     327     381 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.046
   DUF1611_N  48 swreavkeAleaGldvvsGlHerLsddpelaalakk 83 
                 s re v  A++   +   + He L +d e+++la +
  EFC38082.1 182 SDRELVLSAVKSSGHALQSVHESLRNDREIVELAIS 217
                 6688889999999999999************99965 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0018
   DUF1611_N  48 swreavkeAleaGldvvsGlHerLsddpelaalakkkgvkiiD 90 
                 + +e v eA+++ ++v     + L dd+e++  +++k++kii+
  EFC38082.1 338 KDKEIVFEAVSQNINVFQHIDKSLRDDKEFVLRLARKNSKIIQ 380
                 668999**********************************985 PP

>> DUF1154  Protein of unknown function (DUF1154)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0       3.8   1.7e+04      10      16 ..     203     209 ..     203     210 .. 0.85
   2 ?   -2.2   0.2      0.97   4.4e+03      12      19 ..     257     264 ..     255     272 .. 0.68
   3 ?   12.1   1.3   3.4e-05      0.15      10      43 ..     359     393 ..     353     394 .. 0.90

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 3.8
     DUF1154  10 esLkqdK 16 
                 esL++d+
  EFC38082.1 203 ESLRNDR 209
                 79***98 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.97
     DUF1154  12 LkqdKayl 19 
                 Lk dK+++
  EFC38082.1 257 LKLDKKFV 264
                 77777774 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 3.4e-05
     DUF1154  10 esLkqdKay.lKllKKQqKElesLkKkhsKersav 43 
                  sL+ dK++ l+l++K +K ++ L K  +K++  +
  EFC38082.1 359 KSLRDDKEFvLRLARKNSKIIQFLTKSMKKDHEFM 393
                 48*******56*********************877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (400 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       854  (0.0476323); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2446.10
//
Query:       EFC38083.1  [L=1393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-51  174.3   0.0    5.2e-51  172.9   0.0    1.8  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.8e-13   50.6   0.2    9.4e-13   48.3   0.1    2.4  2  PAS_9          PAS domain
    3.9e-07   30.1   0.0    1.1e-06   28.6   0.0    1.8  1  PAS            PAS fold
     0.0016   18.4   0.0      0.005   16.8   0.0    1.9  1  PAS_8          PAS domain
  ------ inclusion threshold ------
      0.011   16.0   0.0      0.022   15.0   0.0    1.5  1  PAS_4          PAS fold
       0.11   11.9   0.1       0.28   10.6   0.1    1.7  1  HNOBA          Heme NO binding associated


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  172.9   0.0   1.7e-54   5.2e-51       3     182 ..    1154    1339 ..    1152    1340 .. 0.94

  Alignments for each domain:
  == domain 1  score: 172.9 bits;  conditional E-value: 1.7e-54
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp..eekaahaaklaelaLdmlealeevav 94  
                     ae++ +vt +F+d+vgftalss++ p ++v++Ln+++  fd+l+d ++++k+ktiGday ++ gl+  +++ +h ++ +++a+d +  +++ + 
     EFC38083.1 1154 AEKFPDVTCFFSDMVGFTALSSKMGPNDLVQMLNTIVIGFDDLMDVYHLEKIKTIGDAYFCAGGLHdlNAQSDHPERTLRFAIDTFGVIRNYNL 1247
                     67899*************************************************************9999*******************88877 PP

  Guanylate_cyc   95 es.....keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182 
                     +      ke++++r+Gi+tGpvvagviG+kk+ yd+wG+++n+Asrmes++k+g+iqvs++tye   + +  ++er ++evkGkg  +ty+l 
     EFC38083.1 1248 KFrrnnlKEQINIRIGINTGPVVAGVIGRKKFAYDLWGDSINTASRMESNSKPGRIQVSRSTYERVFDLGLVFEER-KIEVKGKGMCQTYLLD 1339
                     65456667**********************************************************9889888887.69***********985 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0         2   5.9e+03       5      60 ..     164     242 ..     161     260 .. 0.44
   2 !   48.3   0.1   3.2e-16   9.4e-13       2     103 ..    1010    1114 ..    1009    1115 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2
       PAS_9   5 lidnpdgrilyaNeaalrllGyspeevlgksitdlf..........vtdpeanerlraaleqgrk.............k 60 
                 +i ++++  ++aN   +r   ++p      +i +               +++  +l+ +l++++k             k
  EFC38083.1 164 FIPDESNSTVFANALIKRAVKQHPSTYFKYKIGQKAkevevyaseqLRGAKNMIELKSILRNIEKqtteltslhrhyfK 242
                 5555555566666655555444433322222222222222222222234444444445555555444445555555555 PP

  == domain 2  score: 48.3 bits;  conditional E-value: 3.2e-16
       PAS_9    2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.......kerevevvlirkngetfwvlltaspvkdddge 91  
                  dg+++++ ++ + ++N+aa r++G + ee+++k+i +l+   p  ++++r++l++ ++       k  ++ev+++r n +tf ++++++    d++ 
  EFC38083.1 1010 DGVVVCDAQFWVKSFNPAASRMFGAQQEEFVNKPIYCLM--TPWFHDDVRKFLNASKNntslndaKSASFEVDCVRTNLSTFSARINLFITVFDKKP 1104
                  899**99***888**************************..****************9******************************888888999 PP

       PAS_9   92 lvgiivilrDit 103 
                  +v   ++++Dit
  EFC38083.1 1105 IVT--CFIKDIT 1114
                  999..******9 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.6   0.0   3.7e-10   1.1e-06       3      73 ..    1001    1067 ..     999    1102 .. 0.91

  Alignments for each domain:
  == domain 1  score: 28.6 bits;  conditional E-value: 3.7e-10
                  HHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-EC CS
         PAS    3 lraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesr 73  
                  + ail+++ d+++v D++ ++  +N+aa +++G ++ee ++k+++ l+ +     +++ +++ l+++++++
  EFC38083.1 1001 VNAILNAAVDGVVVCDAQFWVKSFNPAASRMFGAQQEEFVNKPIYCLMTPW----FHDDVRKFLNASKNNT 1067
                  679*********************************************998....9999999988887765 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   1.7e-06     0.005       4      63 ..    1002    1060 ..     999    1064 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.7e-06
       PAS_8    4 ralfesspdgiavvd.lgdrivdvNqaalellGysadlkgellgqllpvlrplle.daeqll 63  
                   a+++++ dg++v+d   + +   N+aa +++G  a+  + +  ++ +  +p+++ d + +l
  EFC38083.1 1002 NAILNAAVDGVVVCDaQFW-VKSFNPAASRMFG--AQQEEFVNKPIYCLMTPWFHdDVRKFL 1060
                  5899***********9999.*************..444443334888888888876666655 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.0   7.3e-06     0.022       1      45 [.    1005    1049 ..    1005    1064 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 7.3e-06
       PAS_4    1 ldslpdalavldpdgrvlyaNaaaaelfgappeellGktlaellp 45  
                  l++  d+++v+d+++ v   N+aa ++fga++ee+++k+ + l++
  EFC38083.1 1005 LNAAVDGVVVCDAQFWVKSFNPAASRMFGAQQEEFVNKPIYCLMT 1049
                  67889*********************************9984433 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   9.3e-05      0.28     193     221 .]    1118    1146 ..    1112    1146 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 9.3e-05
       HNOBA  193 esmkeleeekkrtdeLLysmiPkevAerL 221 
                  + ++ l+ee+k +++LL +++P  vA +L
  EFC38083.1 1118 KHNSLLQEERKHSEDLLLNILPSAVATKL 1146
                  66788*********************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1054  (0.0587874); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.95u 0.34s 00:00:01.29 Elapsed: 00:00:00.53
# Mc/sec: 7948.56
//
Query:       EFC38084.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.9e-10   40.1   5.5    7.5e-10   38.2   5.5    2.1  1  GATA        GATA zinc finger
    6.9e-06   25.9  12.3    6.9e-06   25.9  12.3    2.9  3  PHD         PHD-finger
    0.00015   21.6   3.8    0.00015   21.6   3.8    2.6  2  C1_1        Phorbol esters/diacylglycerol binding domain (C1 
  ------ inclusion threshold ------
       0.04   14.4   0.1       0.14   12.6   0.0    1.9  2  NAPRTase_C  Nicotinate phosphoribosyltransferase C-terminal d
        2.1    8.0   9.5        2.5    7.7   6.6    2.6  2  PHD_2       PHD-finger


Domain annotation for each model (and alignments):
>> GATA  GATA zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2   5.5   2.1e-13   7.5e-10       3      33 ..      12      46 ..       8      47 .. 0.89

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 2.1e-13
        GATA  3 nCgttkTplWRrg....pdgnksLCnaCGlyykkk 33
                +C+t++TplWR+g    + ++ +LCnaCGl+ykk 
  EFC38084.1 12 KCKTSQTPLWRKGwttkEGKPVMLCNACGLHYKKG 46
                7***************6666789**********96 PP

>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.1     0.061   2.2e+02       9      24 ..      27      42 ..      12      45 .. 0.82
   2 !   25.9  12.3   1.9e-09   6.9e-06       1      51 [.      48     102 ..      48     103 .. 0.89
   3 ?   -3.3   0.0       2.5   9.1e+03      36      47 ..     274     285 ..     269     286 .. 0.66

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.061
                TSTTSCEEEETTTSCE CS
         PHD  9 sdeeeelvqCdgCkrw 24
                ++e++ +++C+ C+ +
  EFC38084.1 27 TKEGKPVMLCNACGLH 42
                56788999*****865 PP

  == domain 2  score: 25.9 bits;  conditional E-value: 1.9e-09
                 SBTTTTS......TTSTTSCEEEETTTSCEEETTTSSSTHSHHSHHSSTBSSTTTHT CS
         PHD   1 rCavCkk......ksdeeeelvqCdgCkrwfHqkClkppleseekpegewlCekCke 51 
                 +C  C++      ++d+ee ++ Cd+C+rw+Hq+C + +    e++ + +lC+ C++
  EFC38084.1  48 FCIYCNQiykesdADDKEEPWIGCDSCHRWVHQNCERQNGF--EIKPNGYLCPCCRN 102
                 699999999987667779******************99988..888889******97 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 2.5
                 HHSHHSSTBSST CS
         PHD  36 seekpegewlCe 47 
                 s++ p+ +++C 
  EFC38084.1 274 SDNSPQASFICG 285
                 455666689995 PP

>> C1_1  Phorbol esters/diacylglycerol binding domain (C1 domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.6   0.2    0.0082        29      12      38 ..      11      43 ..       7      45 .. 0.81
   2 !   21.6   3.8   4.2e-08   0.00015       8      45 ..      43      85 ..      41      93 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0082
                -B-TTT-SB-.....-S.SSS-EEEETTT--EE CS
        C1_1 12 tfCkhCgefl.....wg.kekqglkCswCkllv 38
                 +Ck+ + +l      + ++k+ + C++C+l +
  EFC38084.1 11 VKCKTSQTPLwrkgwTTkEGKPVMLCNACGLHY 43
                689999999999995336899********9865 PP

  == domain 2  score: 21.6 bits;  conditional E-value: 4.2e-08
                -SS--B-TTT-SB-....-S.SSS-EEEETTT--EE-CCCCTT CS
        C1_1  8 fkqptfCkhCgefl....wg.kekqglkCswCkllvHkkChek 45
                +k+ +fC +C+++        ke +++ C+ C++ vH++C ++
  EFC38084.1 43 YKKGHFCIYCNQIYkesdADdKEEPWIGCDSCHRWVHQNCERQ 85
                68899************9666*******************987 PP

>> NAPRTase_C  Nicotinate phosphoribosyltransferase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       1.6   5.6e+03      70      85 ..     150     165 ..     138     187 .. 0.58
   2 ?   12.6   0.0   3.8e-05      0.14       8      86 ..     272     347 ..     271     349 .] 0.79

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.6
  NAPRTase_C  70 psleeireyvkeqlae 85 
                 p+le+  + vk+++++
  EFC38084.1 150 PTLETNSKKVKQEMKQ 165
                 3444444444433332 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 3.8e-05
  NAPRTase_C   8 ydkdgkalaDlialadekepkegkeilclhpfdekkrveitp.srvekLlkkvfkdGklvyelpsleeireyvkeqlael 86 
                 y++d+++ a  i+ +d   +++++e+++++p ++kk+      ++ve+L +k f  G  +    ++++  + ++ +l+++
  EFC38084.1 272 YESDNSPQASFICGEDF--IDNQQEFIIWDPLKDKKSSVGVSfEQVENLINKNF--GYSTLFTRKIQSLSAICAYELSNF 347
                 77888899999999988..****************9877766268*****9999..555555666777777777777666 PP

>> PHD_2  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.31   1.1e+03       3      11 ..      32      40 ..      27      42 .. 0.64
   2 ?    7.7   6.6   0.00071       2.5       3      36 .]      67     101 ..      65     101 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.31
       PHD_2  3 pllsCdkCs 11
                p+  C+ C 
  EFC38084.1 32 PVMLCNACG 40
                455566665 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00071
       PHD_2   3 pllsCdkCsvaVHasCYGvskesdgee.WlCrrCe 36 
                 p + Cd+C   VH++C + +  + +   +lC +C+
  EFC38084.1  67 PWIGCDSCHRWVHQNCERQNGFEIKPNgYLCPCCR 101
                 7799************7655544432249999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1861  (0.103798); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2089.94
//
Query:       EFC38085.1  [L=473]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-75  247.1  21.7    1.9e-17   62.7   0.0    9.6 11  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.025   14.9   0.2      0.074   13.4   0.2    1.8  1  UPF0223   Uncharacterised protein family (UPF0223)
       0.11   13.1   0.1       0.43   11.2   0.1    2.1  1  POTRA     Surface antigen variable number repeat


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.3   0.0   2.7e-13   1.6e-09       5      47 ..       1      43 [.       1      45 [. 0.94
   2 !    6.8   0.1   0.00089       5.3       5      49 .]      51      95 ..      47      95 .. 0.85
   3 !    7.9   0.1   0.00043       2.5       2      33 ..      73     104 ..      72     120 .. 0.77
   4 !   31.3   0.0   2.1e-11   1.3e-07      11      49 .]     107     145 ..     101     145 .. 0.94
   5 !   62.7   0.0   3.2e-21   1.9e-17       1      49 []     122     170 ..     122     170 .. 0.99
   6 !   54.1   0.0   1.6e-18   9.3e-15       1      49 []     147     196 ..     147     196 .. 0.97
   7 !   33.7   0.0   3.8e-12   2.3e-08       1      40 [.     173     212 ..     173     215 .. 0.95
   8 !   17.0   0.4     6e-07    0.0036       1      49 []     198     246 ..     198     246 .. 0.98
   9 !   28.9   0.2   1.1e-10   6.8e-07       1      48 [.     280     326 ..     280     327 .. 0.96
  10 !   30.6   0.0   3.4e-11     2e-07       1      35 [.     329     363 ..     329     374 .. 0.93
  11 !   20.3   0.3   5.7e-08   0.00034       1      37 [.     383     419 ..     383     466 .. 0.91

  Alignments for each domain:
  == domain 1  score: 37.3 bits;  conditional E-value: 2.7e-13
     DUF4116  5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47
                + +++k ng  l y+s+eLk+Dke+vl+Av++ + a+ +++e+
  EFC38085.1  1 MRKLCKLNGTMLGYASKELKKDKELVLEAVRSTPEAFHFCDES 43
                5689***********************************9987 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.00089
     DUF4116  5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                v ea k+ ++++++++ e+ n + +vl+ ++  + ++ +++ eL+
  EFC38085.1 51 VYEAAKHASFNITKIDGEMFNRRKFVLALMEYRPEIFIHLPYELK 95
                667888888899999999999999999999999999999999886 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.00043
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkA 33 
                 r +vl +++  ++++ +l+ eLk D  ++  A
  EFC38085.1  73 RKFVLALMEYRPEIFIHLPYELKTDPKVLNLA 104
                 78*********************997766555 PP

  == domain 4  score: 31.3 bits;  conditional E-value: 2.1e-11
     DUF4116  11 kngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 kn ++l  +++++++D+++vlk+v++ng  l++a+++Lr
  EFC38085.1 107 KNLKVLSLVPPSYQKDRDFVLKCVRNNGLDLEFAHPSLR 145
                 56789999*****************************98 PP

  == domain 5  score: 62.7 bits;  conditional E-value: 3.2e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr++vl++v++ng+ l+++ ++L++D+e+v++Avkqng al++ se+Lr
  EFC38085.1 122 DRDFVLKCVRNNGLDLEFAHPSLRKDREVVMEAVKQNGLALEFSSEMLR 170
                 9**********************************************98 PP

  == domain 6  score: 54.1 bits;  conditional E-value: 1.6e-18
     DUF4116   1 DrEivleavkkngsalkylseeLkn.DkeivlkAvkqngtalsyaseeLr 49 
                 DrE+v+eavk+ng+al++ se L+n D+eiv +Avk+ng+a+++ s+ ++
  EFC38085.1 147 DREVVMEAVKQNGLALEFSSEMLRNqDREIVYEAVKSNGNAIEFTSDQFK 196
                 9*********************************************9875 PP

  == domain 7  score: 33.7 bits;  conditional E-value: 3.8e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 DrEiv eavk+ng+a+++ s+ +k+D e++  Av +n  +
  EFC38085.1 173 DREIVYEAVKSNGNAIEFTSDQFKRDLELARMAVMKNHES 212
                 9**********************************99765 PP

  == domain 8  score: 17.0 bits;  conditional E-value: 6e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D E++  av kn +++  +++++k+Dk ++   ++  g+ ++ as+eL+
  EFC38085.1 198 DLELARMAVMKNHESFMLVDSSIKQDKKLIQSFLEETGYYYYIASNELK 246
                 899********************************************97 PP

  == domain 9  score: 28.9 bits;  conditional E-value: 1.1e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 D+E++l+av++ g++l  ++ ++k++ ei+l+ ++  +++++y++ +L
  EFC38085.1 280 DEEFMLNAVRN-GFSLDCVPQKFKQNEEIILESIRHASINFKYVDSSL 326
                 9*********8.*******************************99776 PP

  == domain 10  score: 30.6 bits;  conditional E-value: 3.4e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 +r++vl++vk  g++l y +e+++ D+ei+l+ +k
  EFC38085.1 329 NRDFVLKCVKASGFVLFYTDEKFRMDREIILETLK 363
                 8*******************************998 PP

  == domain 11  score: 20.3 bits;  conditional E-value: 5.7e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 DrEi le+v+  g     +++++ nD e++ ++vk+ 
  EFC38085.1 383 DREILLECVRGSGDLPSQADSNIMNDPEFIVECVKIG 419
                 9**********************************53 PP

>> UPF0223  Uncharacterised protein family (UPF0223)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.2   1.2e-05     0.074      33      80 ..     201     248 ..     194     254 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.2e-05
                 EEHHHHHHHHHHHHHH---HHHHHHHHHHHHCCSS--HHHHHHHHHH- CS
     UPF0223  33 vereellkaYrrFkevvpskseekqldreFekasgyslYrvvkkakes 80 
                   r  ++k+ ++F  v  s  ++k+l + F +++gy  Y +  + k+s
  EFC38085.1 201 LARMAVMKNHESFMLVDSSIKQDKKLIQSFLEETGYYYYIASNELKTS 248
                 568899*********************************888777766 PP

>> POTRA  Surface antigen variable number repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   7.2e-05      0.43       5      57 ..     180     240 ..     176     262 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 7.2e-05
                 EEEEES.S.SS-HHHHHTTTSS........STTSBHCHHHHHHHHHHHHHHHHCTT-EE.EE CS
       POTRA   5 kinfeGnk.ktkdeelrrelel........kegdvynpekleadkealksryanlGyfdasV 57 
                  ++ +Gn  +++ ++++r lel         e   +  + +++dk+ ++s+++++Gy+   +
  EFC38085.1 180 AVKSNGNAiEFTSDQFKRDLELarmavmknHESFMLVDSSIKQDKKLIQSFLEETGYYY-YI 240
                 56666654456666666666663333333333345557889****************98.44 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (473 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.29s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 2976.28
//
Query:       EFC38086.1  [L=542]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.3e-26   91.4   0.0      1e-25   90.5   0.0    1.4  1  Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransf
  ------ inclusion threshold ------
        2.7    8.3   5.3         12    6.2   0.3    3.2  3  CotJB            CotJB protein


Domain annotation for each model (and alignments):
>> Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransferase) C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.5   0.0   1.1e-29     1e-25       1     161 [.     259     437 ..     259     448 .. 0.79

  Alignments for each domain:
  == domain 1  score: 90.5 bits;  conditional E-value: 1.1e-29
  Glyco_transf_10   1 kkklvawvvsncktk.....skRekyvkeLkkhlevdvyGkcgklkveelsekeveelikkykFYLafEnsickDYiTeKlw...naleag.av 85 
                      k+k ++ ++snc++      ++R +++++L+k+++v  yG+cgk+  +e    ++ e++++++FY a Ensi kDY+TeK++   +ale+g  v
       EFC38086.1 259 KNKGICAFISNCDQAgctdlKQRFELLNTLSKYIPVRQYGRCGKNA-QEGPGGKTFEIENNCRFYYAAENSIAKDYVTEKFFeglRALEHGsKV 351
                      78999********9999999**********************9888.999999*****************************433355543145 PP

  Glyco_transf_10  86 Pvvl.GparenyerfvppdsfihvddFkspkelaeyLkkldkneeeYleYfeWrkkykvkkkeeleee............lCklCeklk 161
                       + + G+++   +  +p++ +++ +dF+s+++l +yLkkl++++++++e f+  +  +    +++++              C++C+ + 
       EFC38086.1 352 LMLYrGAPNLRQDWGIPKSLYLDHNDFESVDALGQYLKKLNDDDNAFEERFSKITMQER---KKVDKAlaafnprlgsniPCRICSVIG 437
                      5554255544555679********************************99974433322...222222223445566666788887765 PP

>> CotJB  CotJB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.2     0.021   1.9e+02      36      71 ..      10      45 ..       5      47 .. 0.85
   2 ?    6.2   0.3    0.0013        12      18      62 ..     370     412 ..     369     418 .. 0.90
   3 ?   -1.6   0.0      0.35   3.2e+03      32      63 ..     468     499 ..     463     508 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.021
       CotJB 36 kyskkrkelkkeYeekygPLtldgvseskewkWvee 71
                + s++rke ++ Ye+    Lt+ +++++ ++ W ++
  EFC38086.1 10 NNSTHRKEQIRIYEQITNLLTNPDQTKEGSYGWYRK 45
                4567899999*****************999999876 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0013
       CotJB  18 nLYLDthPddkealelfnkyskkrkelkkeYeekygPLtldgvse 62 
                 +LYLD   +d e ++++ +y kk+++  + +ee++  +t+++ ++
  EFC38086.1 370 SLYLDH--NDFESVDALGQYLKKLNDDDNAFEERFSKITMQERKK 412
                 599995..7999***************************998765 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.35
       CotJB  32 elfnkyskkrkelkkeYeekygPLtldgvses 63 
                 ++fn  +++ k l + Y   yg  +  +++e+
  EFC38086.1 468 SKFNLSEERVKILDDIYHTAYGIFQSANNKEN 499
                 56777788888899999999999888877666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (542 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 3465.57
//
Query:       EFC38087.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       293  (0.0163422); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 1383.05
//
Query:       EFC38088.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.7e-37  127.7   3.6      8e-37  127.2   3.6    1.2  1  Trypsin    Trypsin
     0.0099   16.8   0.3      0.017   16.0   0.3    1.4  1  Trypsin_2  Trypsin-like peptidase domain
  ------ inclusion threshold ------
       0.13   12.4   0.0       0.24   11.5   0.0    1.4  1  DUF1643    Protein of unknown function (DUF1643)


Domain annotation for each model (and alignments):
>> Trypsin  Trypsin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  127.2   3.6   1.3e-40     8e-37       3     221 .]      48     291 ..      46     291 .. 0.87

  Alignments for each domain:
  == domain 1  score: 127.2 bits;  conditional E-value: 1.3e-40
                 SSEETTTTSSTTEEEEEETTC......EEEEEEEEEETTEEEEEGGGTTT..GGGEEEEESE..SBTTSCTTTEEEEEEEEEEEETTEBTTTTTTTEEE CS
     Trypsin   3 ggeeaqkgsfpwqvslsvksg......khlCgGslisenwvlTAaHCvsn..asdvkvvlge..hnlkksegkeqklkvekvivhpnynpstldnDial 91 
                 g++ +++++fp++vs+++ s+       h+C G++is+  ++TA HC  +   +++++++g+  ++ + s+++   ++v k++ hpny++st +nDia+
  EFC38088.1  48 GTSVSSANEFPHMVSIQYYSSssvatgIHFCAGTIISPLHIVTASHCDIGvtLDKLRIIAGNsnNQCTASSTSCTIRTVTKFTKHPNYDSSTIKNDIAI 146
                 566778999*********99999***999******************9999989999999995455666666689999999****************** PP

                 EEESSS......STSBSSBHCCBBCSTTHTTSTTTEEEEEESSBSSTSSBSSBEEEEEEEEEEHHHHHHHTTTTSTTTEEEEESTTSSSBCTTTTTTSE CS
     Trypsin  92 lklkep......vklgdtvrpiclpaassslpvgttclvsGwgrtkekgksdtlqevevpvvsretcksaykgkvtenmlcagakeggkdacqGDSGGP 184
                 ++l++p        +  +++ + l +   s++  +++ ++Gwgrt ++++ +++q+++vp+ + + c+ +  g  ++n++cag   +g d+c GDSGGP
  EFC38088.1 147 IELDQPipldgvRAVAAKIENLTLDQ-FLSSSSSSMVNIAGWGRTTTQSSVQVIQKAMVPISPVSVCNAKNLGVSSPNQICAGN-GNGIDTCGGDSGGP 243
                 ******77666544555555555655.334478899*********************************9556689********.578*********** PP

                 EEETTT...........EEEEEEEEE.SSSSCTTSEEEEEEGGGGHHHH CS
     Trypsin 185 lvcsdg...........elvGivswg.kgcakgnrpgvytkvssyldwi 221
                 l++               l+G+vs+g  gc+  n  g yt+ ++y ++i
  EFC38088.1 244 LFRVIAagtvnnnlpifVLTGVVSYGpPGCGGSNV-GAYTNATQYISFI 291
                 *987666788999********************87.*********9887 PP

>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.3   2.8e-06     0.017       2     142 ..      79     246 ..      72     253 .. 0.61

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 2.8e-06
   Trypsin_2   2 sGflvgsdglilTnaHvv............dsadgaavkaikkkveeagadgrevpakvvaadpel..DlAllkv........ssderaglpplplgps 78 
                  G ++++ + i+T+ H+             + +++ +  +++++ + + +  ++++  + + ++ +  D+A++++            +a+++ l+l++ 
  EFC38088.1  79 AGTIISPLH-IVTASHCDigvtldklriiaG-NSNNQ--CTASSTSCTIRTVTKFTKHPNYDSSTIknDIAIIELdqpipldgVRAVAAKIENLTLDQF 173
                 466777777.999999986655544444421.11111..12334444444444444444444433366*******966666665555555555567776 PP

   Trypsin_2  79 ealkggepvyvvGyplggeksg..............svssGivsgvvesesaasgegesflqtdaatspGsSGGplfd 142
                  +++ ++ v + G ++  + s               sv++ +  gv++ +++    + + ++t      G SGGplf+
  EFC38088.1 174 LSSSSSSMVNIAGWGRTTTQSSvqviqkamvpispvSVCNAKNLGVSS-PNQICAGNGNGIDTCG----GDSGGPLFR 246
                 666667789999985444443377777777777777888888888888.6666666666555555....********7 PP

>> DUF1643  Protein of unknown function (DUF1643)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   4.1e-05      0.24      28     100 ..     117     195 ..     100     221 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 4.1e-05
     DUF1643  28 eedDpTirrvirfakkwgygsltvvNlfayratd.pkdlks...aadpvgkendkvirelakeadkiilaWGn.n.rga 100
                 ++   Tir v +f+k+ +y+s t+ N +a ++ d p  l     +a ++++ +   + +  +++   i++WG+ + + +
  EFC38088.1 117 SSTSCTIRTVTKFTKHPNYDSSTIKNDIAIIELDqPIPLDGvraVAAKIENLTLDQFLSSSSSSMVNIAGWGRtTtQSS 195
                 555679*************************9995555555211334444444444444444456689****6421222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       586  (0.0326845); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2339.57
//
Query:       EFC38089.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.023   14.6   0.2       0.06   13.2   0.2    1.7  1  Mid2      Mid2 like cell wall stress sensor
      0.088   13.3   4.1        4.8    7.7   0.0    3.3  3  SCIMP     SCIMP protein


Domain annotation for each model (and alignments):
>> Mid2  Mid2 like cell wall stress sensor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   6.7e-06      0.06      36      77 ..     399     441 ..     380     445 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 6.7e-06
        Mid2  36 skssGLskknrniviGcvvGigv.PlllvillllyifCikskr 77 
                 s+ss     n+ ++iG+ vG+g+  + +vi ++  ++Ci  kr
  EFC38089.1 399 SSSSSKNGNNQSVIIGVSVGLGLfAFCVVISIISMVICIVVKR 441
                 344444456899**********834667888888999*98776 PP

>> SCIMP  SCIMP protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.21   1.9e+03      51      66 ..      36      51 ..      16      65 .. 0.80
   2 ?    7.7   0.0   0.00053       4.8      83     127 ..     202     247 ..     189     252 .. 0.84
   3 ?    3.7   1.5    0.0087        78      15      32 ..     411     428 ..     408     444 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.21
       SCIMP 51 erdeekmyenvlnqsp 66
                + + +++yen+ ++s+
  EFC38089.1 36 KYNSKQVYENIYESST 51
                4567789999988775 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00053
       SCIMP  83 sspqetksqppatyslvn.kvrnkktvsipsyiePeedyddveiPa 127
                 +  q tk + p++y l++ k+rn k ++  +++e    y+d  iP+
  EFC38089.1 202 KFSQWTKLSCPSSYELIEeKLRNSKEFTSLGFVEGPVSYNDPSIPK 247
                 456677888899***995499*********************9996 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.0087
       SCIMP  15 aiivvsvvlglilycvcr 32 
                  ii vsv+lgl  +cv+ 
  EFC38089.1 411 VIIGVSVGLGLFAFCVVI 428
                 6999***********975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       824  (0.0459591); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.25s 00:00:00.91 Elapsed: 00:00:00.47
# Mc/sec: 2902.60
//
Query:       EFC38090.1  [L=397]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0037   17.7   0.3      0.011   16.2   0.3    1.7  1  CYYR1     Cysteine and tyrosine-rich protein 1
  ------ inclusion threshold ------
      0.061   13.0   0.2        1.3    8.6   0.0    2.5  2  DUF4131   Domain of unknown function (DUF4131)
      0.078   12.7   0.2      0.078   12.7   0.2    2.2  2  FtsK_4TM  4TM region of DNA translocase FtsK/SpoIIIE
        2.1    8.2   7.3       0.14   12.1   0.3    2.2  2  TMEM52    Transmembrane 52


Domain annotation for each model (and alignments):
>> CYYR1  Cysteine and tyrosine-rich protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.3   2.4e-06     0.011      39      85 ..      69     114 ..      52     126 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 2.4e-06
       CYYR1  39 fccsyyayvgdvlsgtaiagivfgvvflmgvvagialcvc.mcvknsr 85 
                 +   y  + g    g ++ag++f +++l  ++a++alc+   cvk++ 
  EFC38090.1  69 YAQQYVNWAGV--IGGSVAGLLFLIIILPTIIACVALCIVgCCVKQTN 114
                 44455555553..37789********************9724566654 PP

>> DUF4131  Domain of unknown function (DUF4131)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.041   1.8e+02      32      64 ..       5      37 ..       2      64 .. 0.75
   2 ?    8.6   0.0    0.0003       1.3       5      65 ..      76     126 ..      72     143 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.041
     DUF4131 32 vllllllllllallgfalrapqpnandlsqlle 64
                 ll++++++++++++++++ +  ++  +s+ ++
  EFC38090.1  5 SLLVFIIVFACFVGCVQASIHLVPQATKSTPAS 37
                567778888888888888777777666665554 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0003
     DUF4131   5 lalvllalllllllllllllrrrprrrvllllllllllallgfalrapqpnandlsqlles 65 
                 +a v+ ++++ ll+l+++          l +++++ +l+ +g+++ + + n+++l++ +++
  EFC38090.1  76 WAGVIGGSVAGLLFLIII----------LPTIIACVALCIVGCCVKQTNSNETELESKNPY 126
                 555555555555555555..........578999999999999999999999888876665 PP

>> FtsK_4TM  4TM region of DNA translocase FtsK/SpoIIIE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2   1.7e-05     0.078      34      78 ..      64     108 ..      50     125 .. 0.78
   2 ?   -2.4   0.1      0.76   3.4e+03      90     108 ..     357     375 ..     343     378 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.7e-05
    FtsK_4TM  34 stsgsaaaavhNwgGrvGAwladlllslfGlsawllvvlllawgl 78 
                 +t ++ a++  Nw+G++G  +a+ll+ ++ l++++  v+l+++g 
  EFC38090.1  64 QTISQYAQQYVNWAGVIGGSVAGLLFLIIILPTIIACVALCIVGC 108
                 567788899******************999999999999998875 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.76
    FtsK_4TM  90 llrllgalllllasaalfa 108
                 l rl+ + +l+++s+++fa
  EFC38090.1 357 LGRLVLFRFLVIVSCGVFA 375
                 5678888888999988887 PP

>> TMEM52  Transmembrane 52
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.3     3e-05      0.14      22      63 ..      86     126 ..      82     135 .. 0.85
   2 ?   -1.9   1.7      0.64   2.9e+03      23      40 ..     360     377 ..     354     380 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3e-05
      TMEM52  22 wLilvivlllLlCgltasCvrfCclrkqqkaeeespparkpy 63 
                 +L+ +i++l  + + +a+C+  Cc+++ +++e+e+++ ++py
  EFC38090.1  86 GLLFLIIILPTIIACVALCIVGCCVKQTNSNETELES-KNPY 126
                 588889999999999**********999999998887.7887 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.64
      TMEM52  23 LilvivlllLlCgltasC 40 
                 L+l   l+++ Cg+ a C
  EFC38090.1 360 LVLFRFLVIVSCGVFACC 377
                 45555556667***9999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       772  (0.0430587); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 2418.70
//
Query:       EFC38091.1  [L=813]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      1e-17   64.3   2.7    1.7e-15   57.0   0.7    2.9  2  Exostosin  Exostosin family


Domain annotation for each model (and alignments):
>> Exostosin  Exostosin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.0   0.7   9.6e-20   1.7e-15       5     292 ..      63     383 ..      60     394 .. 0.70
   2 !    5.5   0.1   0.00047       8.4       6      80 ..     498     568 ..     495     582 .. 0.70

  Alignments for each domain:
  == domain 1  score: 57.0 bits;  conditional E-value: 9.6e-20
   Exostosin   5 lkVYvy...dlpskfnedlleecrelp............etswysaeqfllesllhsrveey.....vrtsdpaeAdlffvpfyaslsenrhllnsalq 83 
                 l++Yvy   +  +++ e++++ c++                ++y ++  +l +     +++y      r+++ +eA + ++p+   +++  + +++  +
  EFC38091.1  63 LRIYVYplsENGKQMYERTIDMCKNHSfdneemtffphaYIDCYLIDFIMLNT-----SNYYdgnliKRVNNIEEANIAYIPIPLVMNFYDNIKKEGEK 156
                 78999955444556666777777666688888888777766777777777775.....22223346889999999999999986666666644444443 PP

   Exostosin  84 drrelqrellewlksqlpy.....WnrsgGrdH...fivlsrptwafrrtakdvdwgsamlv...nltslfseeqyr.....pgkdvvvPypspfhp.. 164
                      + +l e++ks+  +     +n +   +      ++++++ ++r  + +  ++++ +v   n+  + s ++++     + + +++Py + f+   
  EFC38091.1 157 ----DFLNLTEKIKSD--FynemiYNTEMEDNFekvPHFVTYSFVSYRL-SFSGIPKQVKIVtleNVAISGSPQNAWydngcQDRCLTIPYATIFDWps 248
                 ....344444444443..2012224433333332111234444555555.4455555555556888888888888888887555559999999999889 PP

   Exostosin 165 .......eisqwqaaspsnrRktllvFagelrrrsesgkireklleeckgdpdadickgkqctkgrskedylellassrFClvppGdsptsrrlfdall 256
                        ++ ++  ++  ++R++ll+F g l r++     r +l++++++ +   ++ +k++   +s    +e   +s+FCl+ +Gd+pt+  ++++ll
  EFC38091.1 249 aynessnTLYAEDYTHNWKNRPYLLSFIGSLNRTEILFTHRYHLVTKLSEFRGRYFHTFKESISTSS---NIEIYGKSKFCLQLHGDTPTRNAFYESLL 344
                 999999889999999999*************9999999**********6666666666666654333...69999************************ PP

   Exostosin 257 agCIPVii.....sdqielPfedvldwrefsvfvpekdvpe 292
                  gCIPVi      s+   + +  +l  +ef ++++ k ++e
  EFC38091.1 345 MGCIPVITektfiSYRSLFGY--LLPVEEFTIVIDNKYAEE 383
                 *******99998888888777..788899999999888777 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.00047
   Exostosin   6 kVYvydlpskfnedlleecrelpetswysaeqfllesllhsrveeyvrtsdpaeAdlffvpf.yaslsenrhllns 80 
                 k+Y+ ++  ++++d l  ++++ +      e +l++ l++ +    ++ts+ + A l+f pf ++ + ++++l+++
  EFC38091.1 498 KIYIPQFYHELTIDSLSTHNSI-DHLPTLMEFALIQRLKNEN----ILTSNTEHANLIFYPFnLNVIFNQHVLDQQ 568
                 7888778888888877777777.3333455666666666666....****************55555544444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       854  (0.0476323); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.77u 0.31s 00:00:01.08 Elapsed: 00:00:00.50
# Mc/sec: 4890.65
//
Query:       EFC38092.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.4e-07   30.0   2.6    1.9e-06   28.4   2.6    1.8  1  Fz        Fz domain


Domain annotation for each model (and alignments):
>> Fz  Fz domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   2.6   1.1e-10   1.9e-06       1      90 [.      61     162 ..      61     182 .. 0.69

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 1.1e-10
                 -EE-..E...ETT-.S-SEE-GGGS.S-SSHHHHHHHHHHH..HGGGG-.....HHHTTSTTHHHHHHS---EESSS-EEEE..---HHHHHHHHTT-G CS
          Fz   1 Cepi..elelCkai.gynstslpnllgheteeevaeeleef..sllvkl.....eCspalklflCsllfpkCepsgeeeapl..ppCrslCeavrdsCe 87 
                 C p+   +e+C+++ + n +++++   ++ e  + +++++f  ++ v++     +C++ +  + Cs+ f +C+++ +++ +   +pC+ lC++   +C 
  EFC38092.1  61 CVPLttPVEYCSGLiPNNISYITSRSLNTVEPRLISQIDNFitKMEVNYgsitsNCKNSAIDLYCSMSFKRCVHDRSRGLVElyKPCQYLCQELYLNCI 159
                 667766678999986766665555444444445667777775522222255566******************966555443356**************8 PP

                 GGS CS
          Fz  88 kvl 90 
                 ++ 
  EFC38092.1 160 PDR 162
                 854 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1030  (0.0574488); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2213.42
//
Query:       EFC38093.1  [L=361]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.1e-18   65.8  18.3    5.8e-18   65.7  17.3    1.6  1  FA_desaturase  Fatty acid desaturase


Domain annotation for each model (and alignments):
>> FA_desaturase  Fatty acid desaturase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.7  17.3   3.2e-22   5.8e-18       5     248 ..      69     337 ..      64     342 .. 0.77

  Alignments for each domain:
  == domain 1  score: 65.7 bits;  conditional E-value: 3.2e-22
  FA_desaturase   5 alllalllglf.llgitgslaHeaaHgalfkkrklnrwl..ndllgallglplgisysawrisHlrHHay.tngpdeDpdlaplalsrfeglfry. 95 
                    a++la++  ++ ++++   ++He  H+    +++l++++   +l+    g+p+ ++ + ++  Hl+HH   ++g++ Dp+++++  s+++ +f+y 
     EFC38093.1  69 AVVLAFITSFIfYRVM--LFIHESVHQ----SQNLPNFVkyYNLV---NGFPNKVPLYCYKP-HLTHHDPkVYGQANDPEYQSI--SSGSIWFHYl 152
                    5566666666644455..********5....55588888666666...88898888855555.******************976..8888888888 PP

  FA_desaturase  96 ......................llrlllgllvlg........wllalvlglwlrrlarrrapsksrrrkwrllawlllllawlglwlalllllgla 161
                                          +l         +        +++ +++ l++ +++ r+ p+++ ++ w++     + ++ + +++ ++++   +
     EFC38093.1 153 lvpvifqfpvavftclrfnlvpFLL--------PfigskgreFIWRYASTLAMNPFFDRGLPTEQDKKEWYVQDFGCACATTCQFIAIYFGFIEDG 240
                    8888888888777755554332222........233334666777778888999999999999999999999998888888888888888877777 PP

  FA_desaturase 162 ll...lwlvplllllfllalvlnyveHyg.......gdwgerqvetsasirsaswllnlltgnln..yHieHHlfPgvpwyrLpelhrrlrellpe 245
                    l+     l+ + +ll++++++  ++ H +          +++ + +s ++  +  +  +++++ +  yH  HH fP++p+++L ++h +l e l++
     EFC38093.1 241 LSfmrTTLIIVYFLLVVNMYR-AMAAHRYfaephqpPLSRKQMILDSVNYA-SDSWICFFWFPVGtlYHGLHHVFPTIPYHHLARVHSILVEHLRR 334
                    775676666666777777777.99999999999966666666667777777.999999999999999**********************9998888 PP

  FA_desaturase 246 hgl 248
                    +++
     EFC38093.1 335 NDP 337
                    665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (361 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       613  (0.0341904); expected 358.6 (0.02)
Passed bias filter:                      311  (0.0173462); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2288.29
//
Query:       EFC38094.1  [L=541]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.2e-27   96.1   0.0    2.9e-27   95.7   0.0    1.1  1  Pyr_redox_2     Pyridine nucleotide-disulphide oxidoreductase
    3.3e-08   34.0   0.0    6.7e-05   23.4   0.0    2.7  2  Pyr_redox       Pyridine nucleotide-disulphide oxidoreductase
    6.9e-06   25.5   0.0     0.0033   16.7   0.0    2.4  2  Pyr_redox_3     Pyridine nucleotide-disulphide oxidoreductase
     0.0001   21.5   0.0    0.00065   19.0   0.0    2.0  2  K_oxygenase     L-lysine 6-monooxygenase (NADPH-requiring)
    0.00079   19.6   0.0     0.0025   18.0   0.0    1.9  2  NAD_binding_8   NAD(P)-binding Rossmann-like domain
     0.0045   16.6   5.8      0.046   13.3   0.0    2.8  3  DAO             FAD dependent oxidoreductase
     0.0092   15.6   0.0        0.2   11.3   0.0    2.8  3  ApbA            Ketopantoate reductase PanE/ApbA
  ------ inclusion threshold ------
      0.015   14.1   0.7       0.31    9.7   0.0    3.2  4  HI0933_like     HI0933-like protein
      0.083   11.9   0.0        7.5    5.5   0.0    2.4  2  Lycopene_cycl   Lycopene cyclase protein
        0.1   11.5   0.0       0.46    9.3   0.0    2.0  2  Trp_halogenase  Tryptophan halogenase
       0.11   11.6   0.0        7.3    5.6   0.0    2.5  2  GIDA            Glucose inhibited division protein A
       0.13   12.5   0.0        3.6    7.9   0.0    2.7  2  TrkA_N          TrkA-N domain


Domain annotation for each model (and alignments):
>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.7   0.0   1.9e-30   2.9e-27       2     290 ..     143     461 ..     142     465 .. 0.76

  Alignments for each domain:
  == domain 1  score: 95.7 bits;  conditional E-value: 1.9e-30
                  SEEEE--SHHHHHHHHHHHHHTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHHHHHHCHHHHCCCCHCCTCEEEEESCEEEEETEEEC....... CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....... RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaqagakvtlvelegtclnggcllskallgvaedaeiasevvkklnqgielllgeevvkidpgkkkvklekkke....... 92 
                  ++v+iGgG+ G+ +a +l+   + ++l+ +++ + + ++  + +l++v +  +i  +  + l +++++++g   +ki ++ + +   + ke       
   EFC38094.1 143 RLVIIGGGHSGVLTACQLND-YFSIVLI-DKNPHCTLKPAFPVILEKVDHVNKISINYSEILPSNVTFIHG--LTKIVRQDGVFIEIAGKEpqikhml 236
                  79****************99.8******.666666777888777777777776666665667777888888..7777777766666666666777777 PP

                  ...........TCEEEEEESEEEE---E..EE-BCTCTTC..TTBEECCSECH.HHHHHCCSS-T...SEEEEES-SHHHHHHHHHHHHH..T-EEEE CS
                  ...........xxxxxxxxxxxxxxxxx..xxxxxxxxxx.xxxxxxxxxxxx.xxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxx..xxxxxx RF
  Pyr_redox_2  93 ...........gdeekiaydklvlAtGs..sprdlgipGv.aenvgklvrtld.saealklkllp...krivvvGgGyiGvElAaalakl..gkevtl 170
                              + + + +d+lv+AtG+  + + ++++   +en +  v+ ++ +  +l+    +    +ivv+GgG +G+E+ + la+   + + +l
   EFC38094.1 237 tneysdsntdvRNCKFLSFDYLVIATGCngWKNVPQMENPqKENKILYVDGYNmDMVELSVTAINqsnHDIVVIGGGSVGCEYFGSLAQTfpNRNCYL 334
                  7778777766566667788********8557777766644456666666654313344444433378899************99997776566679** PP

                  EESSSSSSTTS-HHHHHHHHHHHHHT.TEEEEESCEEEEEEETTE.EEE.EEETTSCEEEESEEEE-S-EEES-HHCSHCCT-EEEETTEEE--TTS. CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxx.xxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx. RF
  Pyr_redox_2 171 veardrllraldkelsaaleealeke.Gvevklgtsvkeidgnge.kle.vvledgeeidadlvvvavGvrpstelleeklglelderggivvdefl. 264
                  +++ d l++   k++ +a+++ + k+ + +vk++++v + ++ +   ++ ++ +++++i++  +++a G++p+t+  +e  g  +de+++++v+++  
   EFC38094.1 335 IQRSDMLMK-PSKDAHKAATDTFAKMkNANVKFNCQVDRQEDSNIlVVKsLESGEETRIKCCVCFLASGISPNTKMMNEYFGESMDENNYLKVNPSFq 431
                  ******994.45666777777777776**********877777778777899999999******************99999***************94 PP

                  ....BES.STTEEE-GGGCTECCSS--HHHH CS
                  ....xxx.xxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 265 ....rtn.vpgiyaiGDvaggkggpelaqaA 290
                      +++   +i+++GD   + ++ +l+q+A
   EFC38094.1 432 lwksNSEyFNNIFVLGDAN-NADTEKLIQNA 461
                  454334679********77.77777888777 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0    0.0036       5.4       1      22 [.     143     164 ..     143     182 .. 0.86
   2 !   23.4   0.0   4.5e-08   6.7e-05       2      69 ..     307     376 ..     306     385 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0036
                 EEEEECSSHHHHHHHHHHHHTT CS
   Pyr_redox   1 kvvvvGgGyiglElAgalaelg 22 
                 ++v++GgG +g+  A+ l+++ 
  EFC38094.1 143 RLVIIGGGHSGVLTACQLNDYF 164
                 68***************99875 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 4.5e-08
                 EEEECSSHHHHHHHHHHHH.TT.SEEEEEESSSSSSTTSSHHHHHHHHHHHHHT.TEEEECSEEEEEEEEE CS
   Pyr_redox   2 vvvvGgGyiglElAgalae.lg.kkVtvversdkllrllDeeaskilqeklekn.gievllntkveeiegs 69 
                 +vv+GgG +g+E+ g la+ +   + ++++rsd+l+ +  ++a k+ ++ + k+ + +v +n +v + e s
  EFC38094.1 307 IVVIGGGSVGCEYFGSLAQtFPnRNCYLIQRSDMLM-KPSKDAHKAATDTFAKMkNANVKFNCQVDRQEDS 376
                 8****************995443678**********.6666677999999988879999999999887755 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.0    0.0036       5.4     164     193 ..     141     169 ..     115     201 .. 0.73
   2 !   16.7   0.0   2.2e-06    0.0033     143     292 ..     285     429 ..     244     447 .. 0.69

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0036
  Pyr_redox_3 164 gqkvvViGgknSavDaAlelvrkgaeVtvv 193
                  + ++v+iGg+ S+v +A++l ++  ++ ++
   EFC38094.1 141 MPRLVIIGGGHSGVLTACQLNDY-FSIVLI 169
                  45788999999999999988876.444444 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 2.2e-06
  Pyr_redox_3 143 ipGeeklvkhyskvkefhkyagqkvvViGgknSavDaAlelvrk..gaeVtvvtrgseiekeesdpsyslkpdienrleelvkeekikvlfnaevkei 238
                  + G +   ++   v+++ + +++++vViGg+  ++++   l+++  + +  ++ r++ + k ++d          + ++++ +    +v fn +v++ 
   EFC38094.1 285 VDGYN-MDMVELSVTAI-NQSNHDIVVIGGGSVGCEYFGSLAQTfpNRNCYLIQRSDMLMKPSKDAH----KAATDTFAKMKN---ANVKFNCQVDRQ 373
                  34444.44455555555.67799********************998999999999997776554444....444555555433...5799*****998 PP

  Pyr_redox_3 239 kekeeeykvktedgkkvevkddvvla.tGykpdlsflkk.slfeldedgrpvltee 292
                  ++++  +  + e+g+++++k  v ++  G +p+++++++  + + de+++ +++++
   EFC38094.1 374 EDSNILVVKSLESGEETRIKCCVCFLaSGISPNTKMMNEyFGESMDENNYLKVNPS 429
                  8776666666899999999877655549**********988888999999999984 PP

>> K_oxygenase  L-lysine 6-monooxygenase (NADPH-requiring)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       0.6     9e+02     192     205 ..     142     155 ..     121     171 .. 0.80
   2 !   19.0   0.0   4.3e-07   0.00065     151     229 ..     257     342 ..     231     357 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.6
  K_oxygenase 192 kriaVvGsGqSaae 205
                   r++++G+G S+  
   EFC38094.1 142 PRLVIIGGGHSGVL 155
                  5889******9965 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 4.3e-07
  K_oxygenase 151 nlvlgvG..tepkiPevleklegkervvHsseylerkee......llakkriaVvGsGqSaaeifedllrrqkkvelklvtrseale 229
                   lv+++G  +  ++P++ ++ + +++++  + y  ++ e      ++++++i+V+G+G  + e f  l++++++ +  l+ rs+ l 
   EFC38094.1 257 YLVIATGcnGWKNVPQMENPQK-ENKILYVDGYNMDMVElsvtaiNQSNHDIVVIGGGSVGCEYFGSLAQTFPNRNCYLIQRSDMLM 342
                  5899999445689****99988.69*****9999999888999999***********************************998764 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   1.7e-06    0.0025       1      31 [.     146     175 ..     146     178 .. 0.95
   2 ?   -2.9   0.0       5.4   8.1e+03       1       9 [.     309     317 ..     309     338 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.7e-06
                    EE--SHHHHHHHHHHHCCTEEEEEE-SSSSS CS
  NAD_binding_8   1 IvGaGlsGlvaAylLakagfdvlllekrdrl 31 
                    I+G+G sG ++A+ L ++ f+++l++k++++
     EFC38094.1 146 IIGGGHSGVLTACQLNDY-FSIVLIDKNPHC 175
                    9****************9.*********997 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 5.4
                    EE--SHHHH CS
  NAD_binding_8   1 IvGaGlsGl 9  
                    ++G+G  G+
     EFC38094.1 309 VIGGGSVGC 317
                    899998887 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   3.1e-05     0.046       2      30 ..     144     173 ..     143     177 .. 0.84
   2 ?    2.1   3.9     0.077   1.1e+02       1      12 [.     306     317 ..     306     341 .. 0.91
   3 ?   -2.5   0.0         2     3e+03     156     202 ..     357     403 ..     336     411 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3.1e-05
                 EEEECTSHHHHHHHHHHHHTT...EEEEESSS CS
         DAO   2 vviiGGGiiGlstAyeLarrg...Vtllekgd 30 
                 +viiGGG  G+ tA +L       ++l++k++
  EFC38094.1 144 LVIIGGGHSGVLTACQLN--DyfsIVLIDKNP 173
                 79***************4..2357******95 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.077
                 EEEEECTSHHHH CS
         DAO   1 dvviiGGGiiGl 12 
                 d+v+iGGG +G+
  EFC38094.1 306 DIVVIGGGSVGC 317
                 9**********9 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2
                 HHHTT-EEEESECEEEEEEEETCEEEEEEECTEEEEEEEE..EEE--GG CS
         DAO 156 aealGveilegtevtgleeedgkvwgverttpgendaada..vVnaaGa 202
                 a+ + +++ ++++v + e+ ++ v++    ++ge++++++  + +a G+
  EFC38094.1 357 AKMKNANVKFNCQVDRQEDSNILVVKS--LESGEETRIKCcvCFLASGI 403
                 555678999999999876655333333..34455544577667777775 PP

>> ApbA  Ketopantoate reductase PanE/ApbA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.65   9.6e+02       2      32 ..     145     174 ..     144     178 .. 0.80
   2 ?   -0.1   0.0      0.42   6.3e+02      25      76 ..     207     262 ..     203     274 .. 0.75
   3 !   11.3   0.0   0.00014       0.2       1      78 [.     307     383 ..     307     392 .. 0.64

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.65
                 EEES-SHHHHHHHHHHHHHTHCEEEE-SCHH CS
        ApbA   2 ailGaGaiGsllaakLakagadvtlilrsrr 32 
                 +i+G G  G l a++L      ++li+++++
  EFC38094.1 145 VIIGGGHSGVLTACQLND-YFSIVLIDKNPH 174
                 69**************44.566777777765 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.42
                 EEE-SCHHHHHHHHHCEEEEETTCEEEEEECEEECCH......SCCCCS-ESEEEE-S CS
        ApbA  25 tlilrsrrlealkknGlrltseggeeilrppealsae......ekselepidlvivtv 76 
                 t+i      + ++++G+ +++ g+e +++   + + +      ++++   +d++++++
  EFC38094.1 207 TFIHGLT--KIVRQDGVFIEIAGKEPQIKHMLTNEYSdsntdvRNCKFLSFDYLVIAT 262
                 5555544..5589999999999966666555555555557899999999999999987 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 0.00014
                 EEEES-SHHHHHHHHHHHH..HTHCEEEE-SCHHHHHHHHHCEEEEETT....CEEEEEECEEECCHSCCCCS-ESEEEE-SSG CS
        ApbA   1 iailGaGaiGsllaakLak..agadvtlilrsrrlealkknGlrltseg....geeilrppealsaeekselepidlvivtvKa 78 
                 i+++G G++G+ + ++La+   +++ +li rs+ l++ +k+  +  +++    ++ +++    ++++    +++ d  i+ vK+
  EFC38094.1 307 IVVIGGGSVGCEYFGSLAQtfPNRNCYLIQRSDMLMKPSKDAHKAATDTfakmKNANVK----FNCQ---VDRQEDSNILVVKS 383
                 89***************99888888********55554444444444442322222222....2222...34444555555555 PP

>> HI0933_like  HI0933-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.95   1.4e+03      63      93 ..      64      94 ..      29     122 .. 0.68
   2 ?    9.7   0.0   0.00021      0.31       3      35 ..     144     175 ..     142     180 .. 0.85
   3 ?   -0.6   0.0      0.27   4.1e+02     131     167 ..     231     267 ..     206     274 .. 0.70
   4 ?   -0.5   0.2      0.25   3.7e+02       1      28 [.     305     334 ..     305     343 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.95
                 ...STTTTHHHHHHS-HHHHHHHHHHTT--E CS
  HI0933_like 63 ypenpkflksalsrftnedlialveelgvel 93
                  +++p f k   s ft+++li+ + +  +e+
   EFC38094.1 64 QKKGPLFNKMLVSSFTAQNLIDCICKVLLET 94
                 3445555566666666666666655544444 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00021
                  EEEE--SHHHHHHHHHHHHTT--EEEE-SSSSS CS
  HI0933_like   3 viviGgGaAGlmaAisaakrgkrVlllekakkl 35 
                  +++iGgG +G+++A ++ +   +++l++k+++ 
   EFC38094.1 144 LVIIGGGHSGVLTACQL-NDYFSIVLIDKNPHC 175
                  79***************.556889999999876 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.27
                  -EEEEECETTE.EEEEE.TTEEEEESEEEE----SS- CS
  HI0933_like 131 evksvekeedgkfrvktkseeeleadklvlAtGGlSi 167
                  ++k++ ++e +  + ++++ + l+ d+lv+AtG + +
   EFC38094.1 231 QIKHMLTNEYSDSNTDVRNCKFLSFDYLVIATGCNGW 267
                  455555566666667777889999*********9877 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.25
                  -SEEEE--SHHHH..HHHHHHHHTT--EEE CS
  HI0933_like   1 kdviviGgGaAGl..maAisaakrgkrVll 28 
                  +d++viGgG  G   +++++    +++  l
   EFC38094.1 305 HDIVVIGGGSVGCeyFGSLAQTFPNRNCYL 334
                  589******999533555555555555555 PP

>> Lycopene_cycl  Lycopene cyclase protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.015        22       2      36 ..     144     175 ..     143     183 .. 0.87
   2 ?    5.5   0.0     0.005       7.5       1      41 [.     306     346 ..     306     363 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.015
  Lycopene_cycl   2 vvviGaGpAglslAarlteakpglkvvlieaspsl 36 
                    +v+iG+G  g++ A +l   +   ++vli+  p+ 
     EFC38094.1 144 LVIIGGGHSGVLTACQL---NDYFSIVLIDKNPHC 175
                    79***************...777899999987765 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.005
  Lycopene_cycl   1 DvvviGaGpAglslAarlteakpglkvvlieaspsllfpnn 41 
                    D+vviG+G  g+     l++  p+ +  li+ s+ l+ p +
     EFC38094.1 306 DIVVIGGGSVGCEYFGSLAQTFPNRNCYLIQRSDMLMKPSK 346
                    9***********99999999999999999999999988865 PP

>> Trp_halogenase  Tryptophan halogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.0   0.00031      0.46       2      33 ..     144     171 ..     143     179 .. 0.87
   2 ?   -1.2   0.0      0.46   6.9e+02       1      12 [.     306     317 ..     306     340 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00031
                     EEEE--SHHHHHHHHHHHHHTTTSSEEEEEE- CS
  Trp_halogenase   2 ivivGGGtaGwlaAaalakalkgklevtlves 33 
                     +vi+GGG +G l+A+ l+ ++    ++ l+++
      EFC38094.1 144 LVIIGGGHSGVLTACQLNDYF----SIVLIDK 171
                     79*****************99....7888876 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.46
                     EEEEE--SHHHH CS
  Trp_halogenase   1 kivivGGGtaGw 12 
                     +iv++GGG+ G 
      EFC38094.1 306 DIVVIGGGSVGC 317
                     69*******996 PP

>> GIDA  Glucose inhibited division protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0    0.0049       7.3       2      20 ..     144     162 ..     143     233 .. 0.86
   2 ?    3.6   0.0     0.019        29       1      13 [.     306     318 ..     306     362 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0049
                 EEEE-SSHHHHHHHHHHHH CS
        GIDA   2 viViGgGhAGceAAlaaar 20 
                 +++iGgGh+G+  A ++  
  EFC38094.1 144 LVIIGGGHSGVLTACQLND 162
                 68**********9999865 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.019
                 CEEEE-SSHHHHH CS
        GIDA   1 dviViGgGhAGce 13 
                 d++ViGgG  Gce
  EFC38094.1 306 DIVVIGGGSVGCE 318
                 79**********9 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.0    0.0024       3.6       2      32 ..     145     174 ..     144     185 .. 0.91
   2 ?    1.5   0.0      0.23   3.5e+02       1      28 [.     307     336 ..     307     353 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0024
                 EEES-SHHHHHHHHHHHHTTEEEEEEESSHH CS
      TrkA_N   2 iiiGlGrvGrslaeeLseggkdvvvidkdee 32 
                 +iiG G  G   a +L+++ + +v+idk++ 
  EFC38094.1 145 VIIGGGHSGVLTACQLNDYFS-IVLIDKNPH 174
                 8*****************985.*******85 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.23
                 EEEES-SHHHHHHHHHHHHTT..EEEEEEE CS
      TrkA_N   1 iiiiGlGrvGrslaeeLsegg..kdvvvid 28 
                 i++iG G vG +    L +    +++++i 
  EFC38094.1 307 IVVIGGGSVGCEYFGSLAQTFpnRNCYLIQ 336
                 89********99888887743344466665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (541 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       658  (0.0367003); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.49
# Mc/sec: 3290.69
//
Query:       EFC38095.1  [L=653]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-26   93.0   0.0    4.2e-26   91.7   0.0    1.6  1  Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransf
     0.0031   18.1   0.7       0.27   11.8   0.0    2.9  3  Aspzincin_M35    Lysine-specific metallo-endopeptidase
  ------ inclusion threshold ------
       0.11   11.6   0.2       0.16   11.1   0.2    1.3  1  ABC2_membrane_3  ABC-2 family transporter protein
       0.17   11.5   0.0        1.4    8.5   0.0    2.3  2  DUF3562          Protein of unknown function (DUF3562)


Domain annotation for each model (and alignments):
>> Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransferase) C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.7   0.0   9.3e-30   4.2e-26       2     161 ..     402     579 ..     401     590 .. 0.80

  Alignments for each domain:
  == domain 1  score: 91.7 bits;  conditional E-value: 9.3e-30
  Glyco_transf_10   2 kklvawvvsncktk.....skRekyvkeLkkhlevdvyGkcgklkveelsekeveelikkykFYLafEnsickDYiTeKlw...naleaga..v 85 
                      +k ++ ++snc++      ++R +++++L+k+++v  yGkcgk+  +e    ++ e++++++FY a Ensi kDY+TeK++   +al++ga  +
       EFC38095.1 402 NKGICAFISNCDQAgctdlKQRFELLNTLSKYIPVRQYGKCGKNA-QEGPGGKTFEIENNCRFYYAAENSIAKDYVTEKFFegvRALQNGArvI 494
                      577899******9999999**********************9888.999999****************************96556888665115 PP

  Glyco_transf_10  86 PvvlGparenyerfvppdsfihvddFkspkelaeyLkkldkneeeYleYfeWrkkykvkkkeeleee............lCklCeklk 161
                       +  G+++   +   p++ +++ +dF+s+++l +y+kkl++++++++++f+  +  +    +++++              C++C+ + 
       EFC38095.1 495 TLYRGAPNLRQDWGFPKSLYLDHNDFESVDALGQYMKKLNDDDNAFERWFNKMTMQER---KKVDKVldgfehrlgtniPCRICAIVG 579
                      555577755555779********************************99975444433...222222222344455555888887765 PP

>> Aspzincin_M35  Lysine-specific metallo-endopeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.022     1e+02      19     119 ..      90     185 ..      89     196 .. 0.66
   2 ?   -2.9   0.1       2.1   9.3e+03      29      29 ..     241     241 ..     216     298 .. 0.56
   3 !   11.8   0.0   5.9e-05      0.27       6      39 ..     534     567 ..     529     575 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.022
  Aspzincin_M35  19 tdqstrskvaavfskiakeckslnsgsltyscsdvkgsCk.sevlAytvpsslnviylcpaffslpeltkkctgtdsqagtivHEltHftev.agt 112
                    td++ ++ va+ f++ia+  ++ n++  + s +  +++++ ++      +++++ i+  p  ++ +     + ++++q+  i  E+  + ++  +t
     EFC38095.1  90 TDDDADNAVATNFRNIAELDGNENTNIKSASEK--DTKTSlKKDKKEEGDEKKEEIVPPPPIVKRK-----KNKQEKQQDLIFEEIAKLLTNpDQT 178
                    688999***********9754444443333333..3333345555566677778888888888833.....4444457778888888888777778 PP

  Aspzincin_M35 113 dDiaygq 119
                       +yg+
     EFC38095.1 179 SEGSYGW 185
                    8888886 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.1
  Aspzincin_M35  29 a 29 
                    +
     EFC38095.1 241 K 241
                    1 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 5.9e-05
  Aspzincin_M35   6 ksdtarfktwFgttdqstrskvaavfskiakeck 39 
                    + d+++f++wF++ + ++r+kv +v++++++  +
     EFC38095.1 534 NDDDNAFERWFNKMTMQERKKVDKVLDGFEHRLG 567
                    67899**********************9998765 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   3.6e-05      0.16       6     121 ..      63     169 ..      59     225 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 3.6e-05
  ABC2_membrane_3   6 itlllPiilvlllglifsnsveddentpiavvdedn....sslsqqlvealeaspsvelvyevdseeeakkalkngdidgilvipkgfskdllk 95 
                      + ++  ++l++ l+++fs  +    +  i v d+d     +++++++ ++l+ +++++  ++ +se++ k  lk+ + +      +g++k+ + 
       EFC38095.1  63 CLIIGLLLLIIALYWLFSVVS----ENVIIVTDDDAdnavATNFRNI-AELDGNENTN--IKSASEKDTKTSLKKDKKE------EGDEKKEEI 143
                      678888888888899988655....4555555555465543333333.5577777777..8889999999888887655......333333333 PP

  ABC2_membrane_3  96 gesatvtvlinssnlnsskailnaln 121
                        +++++    +++  ++++i + ++
       EFC38095.1 144 VPPPPIVKRKKNKQEKQQDLIFEEIA 169
                      44555555555555555555555555 PP

>> DUF3562  Protein of unknown function (DUF3562)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0       0.2   8.8e+02      35      43 ..     336     344 ..     326     351 .. 0.81
   2 ?    8.5   0.0   0.00032       1.4      12      39 ..     466     493 ..     464     495 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.2
     DUF3562  35 edARvlDYl 43 
                 ++ARv+D +
  EFC38095.1 336 SEARVHDLV 344
                 79*****77 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00032
     DUF3562  12 AeetdaPeelVsrlyedavaalaedARv 39 
                 A e ++ ++ V + + + v+al+++ARv
  EFC38095.1 466 AAENSIAKDYVTEKFFEGVRALQNGARV 493
                 77899**********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (653 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1679  (0.0936472); expected 358.6 (0.02)
Passed bias filter:                      781  (0.0435607); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.79u 0.29s 00:00:01.08 Elapsed: 00:00:00.47
# Mc/sec: 4174.02
//
Query:       EFC38096.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.2e-31  108.1   0.0    3.9e-09   36.5   0.0    5.1  5  FRG1             FRG1-like domain
    2.9e-26   91.9   0.0    1.6e-08   34.7   0.0    4.0  4  Fascin           Fascin domain
    2.7e-05   24.3   0.0       0.11   12.6   0.0    2.7  3  FGF              Fibroblast growth factor
  ------ inclusion threshold ------
      0.035   14.2   0.0        2.6    8.2   0.0    3.4  4  Ribosomal_L37ae  Ribosomal L37ae protein family
       0.22   11.3   0.9         97    2.8   0.0    3.6  5  BRCA2            BRCA2 repeat


Domain annotation for each model (and alignments):
>> FRG1  FRG1-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   6.1e-06     0.022      43      80 ..       8      45 ..       4      48 .. 0.91
   2 !   22.2   0.0   2.6e-08   9.2e-05      42      79 ..      47      84 ..      43      87 .. 0.90
   3 !   18.3   0.0     4e-07    0.0014      36      73 ..      81     118 ..      79     126 .. 0.90
   4 !   17.4   0.0   7.5e-07    0.0027      34      84 ..     120     170 ..     113     171 .. 0.87
   5 !   36.5   0.0   1.1e-12   3.9e-09      40     110 ..     166     236 ..     161     242 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6.1e-06
        FRG1 43 lKsgyGkYlgvdkegilsaraeAisseEqfevvfeegk 80
                l+s +Gk+l ++ +g+++a+ +A ++ E  ++++  g+
  EFC38096.1  8 LRSAHGKFLCIEPSGQVVANRDANGPWETLTLIPYGGN 45
                89******************************998765 PP

  == domain 2  score: 22.2 bits;  conditional E-value: 2.6e-08
        FRG1 42 slKsgyGkYlgvdkegilsaraeAisseEqfevvfeeg 79
                 ++s +GkY+  + +g+++a+ +Ai++ Eqf +v +  
  EFC38096.1 47 VFRSAHGKYVCAEPSGLVIANRDAIGPWEQFSLVQSGS 84
                589******************************98755 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 4e-07
        FRG1  36 asdekislKsgyGkYlgvdkegilsaraeAisseEqfe 73 
                  s ++++++s +Gk +  + +g+++a+ +A+++ Eqf 
  EFC38096.1  81 QSGSHVAFRSAHGKLVCAEPSGLVVANRDAVGPWEQFH 118
                 56789*******************************97 PP

  == domain 4  score: 17.4 bits;  conditional E-value: 7.5e-07
        FRG1  34 kvasdekislKsgyGkYlgvdkegilsaraeAisseEqfevvfeegktall 84 
                  +a ++ i+l+  +G+ l  +++  ++++ +A+++ E+f v  ++gk a+ 
  EFC38096.1 120 SLAPNQTIALRHAHGQLLCAESNHSVVGNRSAVGPWENFHVEHHSGKNAFR 170
                 4568899**********************************9999999875 PP

  == domain 5  score: 36.5 bits;  conditional E-value: 1.1e-12
        FRG1  40 kislKsgyGkYlgvdkegilsaraeAisseEqfev.vfeegktallalaketflsvdeekdivakskkaaee 110
                 k +++s +Gk +  + +g+l+a+ +A+++ Eqf+v +  +g+ al + a++t++ v+++++iv++++ ++  
  EFC38096.1 166 KNAFRSAHGKLMCAEPSGLLVANRDAVGPWEQFTVeLHGNGNIALKS-AHNTYVCVEPSGQIVVNRSAVGAW 236
                 779*******************************98999********.****************99988765 PP

>> Fascin  Fascin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.0   2.9e-11     1e-07      39     111 .]       7      79 ..       3      79 .. 0.96
   2 !   34.7   0.0   4.5e-12   1.6e-08      25     110 ..      35     118 ..      34     119 .. 0.95
   3 !   29.9   0.0   1.4e-10     5e-07      35     111 .]     124     200 ..     116     200 .. 0.92
   4 !   10.3   0.0   0.00017      0.63      68     106 ..     197     236 ..     195     241 .. 0.86

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 2.9e-11
                 EEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEETCEEEEEETTSCEEEECTTTEEEEEESSSSGGGEEEE CS
      Fascin  39 aLrshngkYlsldkdGrvvaeaetkeedtlFelefrgrwallresngryLgigkeglLkasastvgkdelftl 111
                  Lrs+ gk+l ++ +G+vva+++ + +    +l   g+  ++r+ +g+y++++++gl+ a+ +++g+ e f+l
  EFC38096.1   7 HLRSAHGKFLCIEPSGQVVANRDANGPWETLTLIPYGGNYVFRSAHGKYVCAEPSGLVIANRDAIGPWEQFSL 79 
                 59*********************9999999***************************************9985 PP

  == domain 2  score: 34.7 bits;  conditional E-value: 4.5e-12
                 GEEEEEEETTSEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEETCEEEEEETTSCEEEECTTTEEEEEESSSSGGGEEE CS
      Fascin  25 qlftLefdeesyavaLrshngkYlsldkdGrvvaeaetkeedtlFelefrgrwallresngryLgigkeglLkasastvgkdelft 110
                 +++tL    ++y+  +rs+ gkY+ ++ +G v a+++   +  +F+l  +g ++++r+ +g+ ++++++gl++a+ ++vg+ e f 
  EFC38096.1  35 ETLTLIPYGGNYV--FRSAHGKYVCAEPSGLVIANRDAIGPWEQFSLVQSGSHVAFRSAHGKLVCAEPSGLVVANRDAVGPWEQFH 118
                 5788888888999..******************************************************************99996 PP

  == domain 3  score: 29.9 bits;  conditional E-value: 1.4e-10
                 SEEEEEEETTSEEEEE-TTSBEEEEESS--GGGEEEEEEETCEEEEEETTSCEEEECTTTEEEEEESSSSGGGEEEE CS
      Fascin  35 syavaLrshngkYlsldkdGrvvaeaetkeedtlFelefrgrwallresngryLgigkeglLkasastvgkdelftl 111
                 ++++aLr + g+ l ++++ +vv +++   +   F +e ++++ ++r+ +g+ ++++++glL+a+ ++vg+ e ft+
  EFC38096.1 124 NQTIALRHAHGQLLCAESNHSVVGNRSAVGPWENFHVEHHSGKNAFRSAHGKLMCAEPSGLLVANRDAVGPWEQFTV 200
                 44569**********************************************************************96 PP

  == domain 4  score: 10.3 bits;  conditional E-value: 0.00017
                 EEEEEEE.TCEEEEEETTSCEEEECTTTEEEEEESSSSGG CS
      Fascin  68 lFelefr.grwallresngryLgigkeglLkasastvgkd 106
                 +F++e + ++ ++l++ +  y++++++g+++ + s+vg+ 
  EFC38096.1 197 QFTVELHgNGNIALKSAHNTYVCVEPSGQIVVNRSAVGAW 236
                 6999999889999999999999999999999999998875 PP

>> FGF  Fibroblast growth factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.0   3.1e-05      0.11       5      69 ..       8      70 ..       5      94 .. 0.81
   2 ?   -0.7   0.0      0.39   1.4e+03      21      69 ..     104     151 ..      85     190 .. 0.54
   3 !    8.6   0.0   0.00055         2      13      68 ..     177     231 ..     167     238 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.1e-05
         FGF  5 LYcrtgfhlqilpdgkvdgtkeenskysileiesvsvgvvrikgvesgrYlamnkkGrLygsenf 69
                L +++g++l i+p+g+v ++++ n + ++l++ +++   v     ++g+Y++ + +G +++++++
  EFC38096.1  8 LRSAHGKFLCIEPSGQVVANRDANGPWETLTLIPYGGNYV--FRSAHGKYVCAEPSGLVIANRDA 70
                557789****************************966544..4567899********99998875 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.39
         FGF  21 vdgtkeenskysileiesvsvgvvrikgvesgrYlamnkkGrLygsenf 69 
                 v ++++   + +++ ++    + ++++++ +g+ l+ +++  ++g++++
  EFC38096.1 104 VVANRDAVGPWEQFHFSLAPNQTIALRHA-HGQLLCAESNHSVVGNRSA 151
                 44444444445555554444455555543.3444555555555555444 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00055
         FGF  13 lqilpdgkvdgtkeenskysileiesvsvgvvrikgvesgrYlamnkkGrLygsen 68 
                 +  +p+g   ++++   + +++++e  + g +++k++ +++Y++++ +G+++ +++
  EFC38096.1 177 MCAEPSGLLVANRDAVGPWEQFTVELHGNGNIALKSA-HNTYVCVEPSGQIVVNRS 231
                 55566666667777778889999999999******96.689*********998776 PP

>> Ribosomal_L37ae  Ribosomal L37ae protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       2.1   7.6e+03      29      53 ..      10      35 ..       5      39 .. 0.66
   2 ?    1.0   0.0      0.13   4.6e+02      28      54 ..      49      76 ..      44      96 .. 0.74
   3 ?   -0.5   0.0      0.38   1.3e+03      32      59 ..     134     162 ..     127     188 .. 0.73
   4 ?    8.2   0.0   0.00072       2.6      28      54 ..     211     238 ..     196     245 .] 0.82

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.1
                     HHHS-BEE.SSSSSSEEEEEETTEEE CS
  Ribosomal_L37ae 29 sqhakytC.pfcgktkvkRkavgiwk 53
                     s h k+ C +  g+   +R a g w+
       EFC38096.1 10 SAHGKFLCiEPSGQVVANRDANGPWE 35
                     66778888333455566777777776 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.13
                     HHHHS-BEESS.SSSSEEEEEETTEEEE CS
  Ribosomal_L37ae 28 isqhakytCpf.cgktkvkRkavgiwkC 54
                      s h ky C++  g    +R a+g w+ 
       EFC38096.1 49 RSAHGKYVCAEpSGLVIANRDAIGPWEQ 76
                     578999**97614555778999988875 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.38
                      S-BEESSSSSSEE.EEEETTEEEETTTTE CS
  Ribosomal_L37ae  32 akytCpfcgktkv.kRkavgiwkCkkcgk 59 
                       +  C++ +++ v +R+avg w+  ++++
       EFC38096.1 134 GQLLCAESNHSVVgNRSAVGPWENFHVEH 162
                      55557777776443799999998766655 PP

  == domain 4  score: 8.2 bits;  conditional E-value: 0.00072
                      HHHHS-BEE.SSSSSSEEEEEETTEEEE CS
  Ribosomal_L37ae  28 isqhakytC.pfcgktkvkRkavgiwkC 54 
                      +s h++y C +  g+  v+R+avg w+ 
       EFC38096.1 211 KSAHNTYVCvEPSGQIVVNRSAVGAWEQ 238
                      689******4456777**********86 PP

>> BRCA2  BRCA2 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       2.1   7.4e+03       9      13 ..      10      14 ..       9      17 .. 0.84
   2 ?    2.3   0.0     0.038   1.4e+02       7      15 ..      48      56 ..      41      57 .. 0.77
   3 ?    2.8   0.0     0.027        97       6      15 ..      87      96 ..      77      97 .. 0.81
   4 ?    2.1   0.0     0.045   1.6e+02       6      13 ..     168     175 ..     164     178 .. 0.85
   5 ?   -3.4   0.0       2.3   8.2e+03       8      17 ..     211     220 ..     211     220 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.1
       BRCA2  9 TAsGK 13
                +A+GK
  EFC38096.1 10 SAHGK 14
                89**9 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.038
       BRCA2  7 FkTAsGKkI 15
                F++A+GK +
  EFC38096.1 48 FRSAHGKYV 56
                *******66 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.027
       BRCA2  6 gFkTAsGKkI 15
                +F++A+GK +
  EFC38096.1 87 AFRSAHGKLV 96
                5******955 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.045
       BRCA2   6 gFkTAsGK 13 
                 +F++A+GK
  EFC38096.1 168 AFRSAHGK 175
                 6******9 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 2.3
       BRCA2   8 kTAsGKkIrV 17 
                 k+A+++ ++V
  EFC38096.1 211 KSAHNTYVCV 220
                 789*998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       264  (0.0147247); expected 358.6 (0.02)
Passed bias filter:                      245  (0.013665); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1530.26
//
Query:       EFC38097.1  [L=405]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.3e-08   32.4   1.6    1.7e-07   30.8   1.6    1.8  1  Exostosin        Exostosin family
    0.00065   19.8   0.8      0.002   18.2   0.0    2.1  2  Gal_GalNac_35kD  Galactose-inhibitable lectin 35 kDa subunit


Domain annotation for each model (and alignments):
>> Exostosin  Exostosin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   1.6   1.9e-11   1.7e-07       6     286 ..      12     336 ..       8     344 .. 0.82

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 1.9e-11
   Exostosin   6 kVYvydlpskfnedlleecrelp..........................................etswysaeqfllesllhsrveey.vrtsdpaeAd 61 
                 k+Y+y+  + fn++l e+                                               +++ ys+  ++le+ lh r   +  r+++ ++Ad
  EFC38097.1  12 KIYIYEDFPNFNIKLFENDGIQIskneifkyknldsisqnivaniknliigkeiklkitpfgnniNSKFYSTSEQVLEPYLHYRLLTHpNRVANIQDAD 110
                 9****88899****999886666999************************************************************************* PP

   Exostosin  62 lffvpfyaslsenrhllnsalqdrrelqrellewlksqlpyWnrsgGrdHfivlsrptwafrr...takdvdwgsamlv.....nltslfseeqyrpgk 152
                 l f+pfy+ l    ++ ++ +     +  +++++ +s lp    +    H+i  s+   +++    +  ++ +++   v     + +s ++  +  p++
  EFC38097.1 111 LAFIPFYSHLLKFATKNGNII-----PLNTIIQYTNSLLPKTT-NTNIPHLIAYSDLGYNTKEalrEMFKFAPNNFYFVcyeedQSSSGYYLPKKAPSR 203
                 **********99996666665.....56677777777777543.4557899999999999998898899999999999988888888888888888*** PP

   Exostosin 153 dvvvPypspfhp...eisqwqaaspsnrRktllvFagel...rrrsesgkireklleeckgdpdadickgkqctkgrskedylellassrFClv...pp 242
                  ++vPy+s +h+   e++ ++  + +++R+++    g+l   + ++ s+ ++  + + ++++++++  + ++         ++    + +F ++     
  EFC38097.1 204 VITVPYMSIIHKskfENFYENF-KIMKNRTFFTCHVGNLnrwPIQYMSKYLSTPFYTSLSNEQASNLGNLIE---------FY---SNCKFSIHissLD 289
                 ************8766666655.56688**********8766666666666666777776666665555555.........44...5555555555599 PP

   Exostosin 243 GdsptsrrlfdallagCIPVii.....sdqielPfedvldwrefsvfvp 286
                 G++  sr ++ +l  g IP+++     s++    f  +ld + +++++p
  EFC38097.1 290 GEMRISRHFYTSLTTGTIPILFnsnemSYS--SLFRGALDLEMMAIIIP 336
                 **********************96533333..33566788888888887 PP

>> Gal_GalNac_35kD  Galactose-inhibitable lectin 35 kDa subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.24   2.1e+03      80     115 ..      68     108 ..      46     171 .. 0.74
   2 !   18.2   0.0   2.2e-07     0.002     102     153 ..     331     383 ..     310     389 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.24
  Gal_GalNac_35kD  80 llrplkkgnelqffe.....fapykmfisfaipkrvhdirg 115
                      ++ p+ ++ + +f+      + py  +  ++ p+rv +i++
       EFC38097.1  68 KITPFGNNINSKFYStseqvLEPYLHYRLLTHPNRVANIQD 108
                      55566666666666422222357777888888888887765 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 2.2e-07
  Gal_GalNac_35kD 102 isfaipkrvhdirggaekgatliiwskkppldegtknqrfvyvh.pyddypst 153
                      ++  ip+ +h+ir+  e++  +i + k  pl+   k +rf+y h  y +y+ +
       EFC38097.1 331 MAIIIPNSIHQIRDEKEQSWAIINYLKSIPLNVFEKKRRFIYDHlQYLQYSME 383
                      56789**************************************9557778765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       714  (0.0398237); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2323.71
//
Query:       EFC38098.1  [L=472]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.6e-06   27.0  11.2    6.2e-06   26.2  11.2    1.4  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
        1.2    9.8   4.3       0.61   10.7   0.9    2.2  2  Bin3      Bicoid-interacting protein 3 (Bin3)


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2  11.2   6.9e-10   6.2e-06       2      39 ..     180     216 ..     179     217 .. 0.94

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 6.9e-10
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 +C+nCr+ +  Cd+k P+C +C +++ +C+ y+ ++++
  EFC38098.1 180 SCNNCRRVHKFCDRKLPSCERCSTKGMTCE-YKIPKRM 216
                 8*****************************.9998875 PP

>> Bin3  Bicoid-interacting protein 3 (Bin3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.9   6.9e-05      0.61      32      95 ..      77     141 ..      68     151 .. 0.79
   2 ?   -1.8   0.1      0.56     5e+03      54      76 ..     246     268 ..     216     283 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 6.9e-05
        Bin3  32 llkpgGvlilEpqewksYkkkkklseelkenyke.lklrpedfeevLleevgfesveeleekeee 95 
                 +l  +   i+E+q+ +sY+   + + ++++n ++    + ++f++ ++ ++ f++ ++l+++ ++
  EFC38098.1  77 SLYDNSNTIIEQQQQHSYQPYDSFNFTTTNNTNNnSTTNGDTFSSSINAQILFNNNNNLNNNLNN 141
                 56667788***********88888777777755527778889***************99977655 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.56
        Bin3  54 klseelkenykelklrpedfeev 76 
                 ++s+ +++n+++ k+ +++f+++
  EFC38098.1 246 NTSNYINNNINKSKIYEQAFNNI 268
                 33344444455555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (472 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2402  (0.133973); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.46
# Mc/sec: 3107.72
//
Query:       EFC38099.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.38   11.3   4.9         14    6.2   0.6    2.6  2  zf-C4pol   C4-type zinc-finger of DNA polymerase delta
       0.84    9.5  12.6        2.5    7.9   6.0    2.3  2  DUF4811    Domain of unknown function (DUF4811)
        1.9    7.2   5.8       0.48    9.2   2.5    1.6  2  Mitofilin  Mitochondrial inner membrane protein


Domain annotation for each model (and alignments):
>> zf-C4pol  C4-type zinc-finger of DNA polymerase delta
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.3    0.0026        16      52      66 ..     189     203 ..     166     204 .. 0.72
   2 ?    6.2   0.6    0.0023        14      28      61 ..     221     255 ..     216     257 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0026
    zf-C4pol  52 sleeevkCdsrdCpv 66 
                 + +++++C+s+dC++
  EFC38099.1 189 NSSTSTSCSSNDCNI 203
                 3347899******98 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0023
    zf-C4pol  28 lsrlkelekklneletvCqsCaqgsle.eevkCds 61 
                 ++++k le+  ++l+t+C + ++++++ ++v Cd+
  EFC38099.1 221 QEETKGLESSSSHLNTLCTTTTTSEVDaNNVPCDC 255
                 5678899**************88888779999986 PP

>> DUF4811  Domain of unknown function (DUF4811)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   6.0   0.00042       2.5      65     135 ..      14      83 ..       5      95 .. 0.86
   2 ?    5.4   0.5    0.0026        16      65     113 ..     166     212 ..     150     219 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00042
     DUF4811  65 gkekvylYktkekqkkpkhtkadikttnkvketssskAklvtkttrwvykndfskllFgiagnnnelvkrk 135
                  + ++  Y+t+++++k + + ++ ++t kvk + + ++++ +k++r +   + +k+l + ++ +++  + +
  EFC38099.1  14 ASSNINKYNTNNNNNKMSFIDETNNVTLKVKVN-QRNNNMHIKQSRLRKPLQNDKFLLNYFEFDKQQHSND 83 
                 5568999************************97.999**********999999999999988887766655 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0026
     DUF4811  65 gkekvylYktkekqkkpkhtkadikttnkvketssskAklvtkttrwvy 113
                  + +++ Y ++++++  ++t+++ ++++++  + s++ +++ +  ++ +
  EFC38099.1 166 LSPQIVNYSNNNESNSSNATTTT-NSSTSTSCS-SNDCNITDSNDNYYW 212
                 4568999***9999887776666.555555543.777777777777766 PP

>> Mitofilin  Mitochondrial inner membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   2.5     8e-05      0.48     233     295 ..       2      64 ..       1      81 [. 0.91
   2 ?   -1.8   0.1      0.17     1e+03     153     183 ..     165     195 ..     145     240 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 8e-05
   Mitofilin 233 kkveekvekaqslaklvekykelveeerevFqqelesiipeiitnlkednkklskddlnslia 295
                 k+  ++v + ++ ++ ++ky+ +++++++ F++e+ +++  + +n  + n+ +++++l ++++
  EFC38099.1   2 KQEYQQVFNPRNASSNINKYNTNNNNNKMSFIDETNNVTLKVKVNQRNNNMHIKQSRLRKPLQ 64 
                 566778888999999*****************************************9999875 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.17
   Mitofilin 153 deakkavkeavdklkeasdteeksrekardt 183
                   ++++v+ +++++ ++s+++++ +++++++
  EFC38099.1 165 PLSPQIVNYSNNNESNSSNATTTTNSSTSTS 195
                 3344555555555555555554444444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2118  (0.118133); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1639.91
//
Query:       EFC38100.1  [L=287]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.18   11.4   9.9       0.28   10.7   9.9    1.3  1  SR-25     Nuclear RNA-splicing-associated protein
        1.2    9.0   6.8        2.8    7.8   0.1    2.1  2  Noggin    Noggin


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   9.9   3.2e-05      0.28      36     118 ..     189     266 ..     163     280 .. 0.51

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 3.2e-05
       SR-25  36 sqsrkassasekeeerskekkkkkrrrssssssssssssssssssssssssdd....rkkrgkkkdkkkkkkkkkkkkkkekkkake 118
                 +++rk s++s+ e+e++k     ++ +++ ss+sss+  +ss s+  +s ++                ++ k+ k+++k +k+k++ 
  EFC38100.1 189 KRKRKISNVSSFESEKRKTSISSTTPPTTCSSNSSSIGNNSSLSTNVHSQQSFnnciI---------ISNPKHLKRRRKYQKRKNSA 266
                 3455555555555555555555555555555555555555554444444333333441.........33333333344444444433 PP

>> Noggin  Noggin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.1   0.00032       2.8      19      60 ..      86     127 ..      66     148 .. 0.82
   2 ?    3.1   2.7    0.0085        76      17     129 ..     151     260 ..     134     276 .. 0.52

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00032
      Noggin  19 ylrlrPvPsdnlpvvdliedPdPaldPkekdlneteLraklg 60 
                    + P+P+++l +  l  +P P  +P + +  e++L ++++
  EFC38100.1  86 CHIVLPSPTETLSLLTLNTSPSPHQQPFNANTIENSLTNTIS 127
                 44567**********************999988888877765 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.0085
      Noggin  17 qhylrlrPvPsdnlpvvdliedPdPaldPkekdlneteLraklgskfdpnflsvsaPeeeklsgaeeleeldaklrlkatgalpkeikkldlkealkkg 115
                  +++   P Ps+++ ++ l+++ +     ++kd n + L++k   +  ++f s +  ++   s++  ++   + +   ++++l +++++ +  ++    
  EFC38100.1 151 HEHYDQSPPPSNDISMMPLQQQTNVNNTFNKKDDN-RILKRKRKISNVSSFESEKRKTSIS-STTPPTTCSSNSSSIGNNSSLSTNVHSQQSFNNCIII 247
                 45778899************999988777777744.4454444333333344333332211.1111111222223344444444444444333332221 PP

      Noggin 116 kkkklskklrrklq 129
                   + ++ k+rrk q
  EFC38100.1 248 -SNPKHLKRRRKYQ 260
                 .1111222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (287 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1193  (0.0665402); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.25s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1899.25
//
Query:       EFC38101.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.011   15.4  10.1      0.019   14.6  10.1    1.4  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6  10.1   1.1e-06     0.019      56     122 ..     268     334 ..     223     345 .. 0.48

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.1e-06
       SR-25  56 kkkkrrrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkakekaka 122
                 + + ++r++ssssssss+s+ ss +  ss s + k   ++    ++ k+ k+++k +k+k++ +++ 
  EFC38101.1 268 SFESEKRKTSSSSSSSSTSNVSSIGNNSSLSTTFKTPLNNCIVISNPKHLKRRRKYQKRKNSANTNP 334
                 2222333344444444444444444444444444444455555555566656666666666644333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1286  (0.0717274); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 2223.29
//
Query:       EFC38102.1  [L=172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       610  (0.0340231); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1151.27
//
Query:       EFC38103.1  [L=389]
Description: vWFA domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-11   44.9   0.0    3.2e-11   43.8   0.0    1.5  1  VWA_2     von Willebrand factor type A domain
    2.8e-09   37.5   0.0    5.1e-09   36.6   0.0    1.4  1  VWA       von Willebrand factor type A domain
  ------ inclusion threshold ------
       0.05   11.5   0.0      0.076   11.0   0.0    1.2  1  TssR      Type VI secretion system, TssR
       0.12   12.3   0.0       0.25   11.3   0.0    1.5  1  VWA_3     von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.8   0.0   7.1e-15   3.2e-11       1     106 [.      81     190 ..      81     191 .. 0.91

  Alignments for each domain:
  == domain 1  score: 43.8 bits;  conditional E-value: 7.1e-15
       VWA_2   1 lvfvlDtSgSmrngdygptrleaakdaveallksl....pgd.rvglvtfsdg....pevlipltkdkakilnalrnleakgggtnlaaaLqlarkalk 90 
                 lv+v+D +gSm+++      +e ak+ v++++++l    + d r++ v+++d+    + +++p+tkd +k + +++ + a+ gg +  +aL  a  +++
  EFC38103.1  81 LVIVMDCTGSMSGE------IEVAKRTVTTIISTLhekfQSDlRFSAVSYRDHtddyAVKEFPFTKDLNKAKGYINTMSAQ-GGGDHPEALASALYVIN 172
                 79***********8......*************8766556668*********53455799*******************96.999************** PP

       VWA_2  91 krr..kgekrvivlitDg 106
                 +++  k+ k+++v+++D+
  EFC38103.1 173 EMPfnKKGKKIVVWVADA 190
                 **9999**********96 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6   0.0   1.1e-12   5.1e-09       1     169 [.      80     268 ..      80     272 .. 0.79

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 1.1e-12
                 EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHT.BTTTTEEEEEEEESSS....EEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHH CS
         VWA   1 DivfvlDgSgsmgeenfekvkefikklvekle.vgpegtrvglvqfsse....vktefslndysskeellsalnnlkysgggttntgkalkyaleklfk 94 
                 D+v+v+D+ gsm  +++e +k+ + ++++ l    + + r++ v++ ++    +  ef+++++   ++++ ++n+++ +ggg+    +al+ al  + +
  EFC38103.1  80 DLVIVMDCTGSM-SGEIEVAKRTVTTIISTLHeKFQSDLRFSAVSYRDHtddyAVKEFPFTKD--LNKAKGYINTMSAQGGGDH--PEALASALYVINE 173
                 9***********.9999999999999999999448899*********8888889999*****5..589********99999999..9************ PP

                 HHGTSSTTSEEEEEEEES...............S--CSS........HTHHHHHHHHGCTEEEEEEEESSSHHHHHHHHH....SSSSCHHCEEEESSH CS
         VWA  95 ssagaRenakkviilltd...............Gksndg........dpkeaaneakeqgikvfavGvgnadekelLnki....asepgeghvftvtdf 166
                 +  +++   kk+++ ++d               G             d  +    ++e+++ ++ + +  a ++++L+ +     +++ +g+   +td 
  EFC38103.1 174 MPFNKK--GKKIVVWVADapphgmktssdsypeG----CkdqqgnviDWIKLGSALQEKNVVFYGILCERAKDDQQLTLFmdylTTKT-DGKCLLLTDA 265
                 ****55..5*********8888766655555553....04444567888888888889999999999977777777876666533333.3666666666 PP

                 HHH CS
         VWA 167 eel 169
                 +++
  EFC38103.1 266 NKI 268
                 655 PP

>> TssR  Type VI secretion system, TssR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   1.7e-05     0.076     302     379 ..      79     155 ..      68     187 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.7e-05
        TssR 302 iNivFvidgssemkkylpqlvnliqsLetkfekssrktsvkfGavvykddrgnkkpgtsslstdykkllsfLekeaks 379
                 + +v v+d   +m+ +++  + ++ ++  ++ + + +++++f+av y+d+++ + + ++ +++d +k    +++++++
  EFC38103.1  79 VDLVIVMDCTGSMSGEIEVAKRTVTTIISTLHE-KFQSDLRFSAVSYRDHTDDYAVKEFPFTKDLNKAKGYINTMSAQ 155
                 556667777777777777666666666666655.55679****************************99999998887 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   5.6e-05      0.25       2      88 ..      80     168 ..      79     204 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5.6e-05
       VWA_3   2 evvivvDvsssmsaen....klvkdaLsvalrqLptndkiavllfgtkprplfpgsravsaaelqealqkikelelslgasnlegaLkeal 88 
                 ++viv+D + sms+e+     +v   +s + +++++  +++ ++ ++ ++    +      ++l +a+ +i+++++ +g+ +   aL+ al
  EFC38103.1  80 DLVIVMDCTGSMSGEIevakRTVTTIISTLHEKFQSDLRFSAVSYRDHTDDYAVKEFPFT-KDLNKAKGYINTMSA-QGGGDHPEALASAL 168
                 79**************66666666666666677777777777777776666654444444.589999999999999.66666666666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       715  (0.0398795); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2345.26
//
Query:       EFC38104.1  [L=1189]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.083   13.0   0.0       0.21   11.8   0.0    1.6  1  DUF4761   Domain of unknown function (DUF4761)


Domain annotation for each model (and alignments):
>> DUF4761  Domain of unknown function (DUF4761)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   1.2e-05      0.21      45      91 ..     259     305 ..     218     314 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.2e-05
     DUF4761  45 wliekagivvhkcprnpltgnrifalssgdnqfgqdftlyealrtvd 91 
                  +++    v+  + rn +   + f l++ d q+  dftl+   r  d
  EFC38104.1 259 IVVDENSQVLEVTSRNSVNSYQSFVLTCSDRQLTSDFTLFMFARKYD 305
                 56777888899999*************************98777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 6796.91
//
Query:       EFC38105.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.094   12.6   0.3        8.8    6.2   0.1    2.5  2  TMEM52    Transmembrane 52


Domain annotation for each model (and alignments):
>> TMEM52  Transmembrane 52
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.1   0.00049       8.8      78     124 ..     199     244 ..     180     247 .. 0.93
   2 ?    4.0   0.0    0.0024        43      13      43 ..     323     354 ..     310     356 .] 0.74

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.00049
      TMEM52  78 stvtslssvqgpaarrillvaheldsdsalppassldtlelpPsYeE 124
                  t+tsl+ ++      ++ ++ +++  +++p+ +s+d+l + P +e+
  EFC38105.1 199 KTLTSLKEMYETRRNSMPSITTQKSVGNQTPQLYSMDSL-ISPQFED 244
                 599**********9*************************.9999885 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.0024
      TMEM52  13 aewvsLwyvwLi.lvivlllLlCgltasCvrf 43 
                   ++sL+++ +  lv+ + l +C ++a+ v+f
  EFC38105.1 323 YAKKSLYFIIMYdLVMFATLFICIVVALIVKF 354
                 455677776654388889999********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1442  (0.0804284); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2096.57
//
Query:       EFC38106.1  [L=107]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-12   47.7   0.0    1.8e-12   47.3   0.0    1.1  1  GST_C            Glutathione S-transferase, C-terminal domain
    4.3e-12   46.1   0.0    4.8e-12   45.9   0.0    1.1  1  GST_C_3          Glutathione S-transferase, C-terminal domain
      6e-11   42.2   0.0    7.4e-11   41.9   0.0    1.1  1  GST_C_2          Glutathione S-transferase, C-terminal domain
      0.007   16.1   0.0       0.01   15.6   0.0    1.4  1  GST_C_6          Glutathione S-transferase, C-terminal domain
  ------ inclusion threshold ------
       0.11   13.1   0.0       0.11   13.0   0.0    1.3  1  GST_C_5          Glutathione S-transferase, C-terminal domain
       0.16   11.8   0.0       0.23   11.3   0.0    1.3  1  Glutaredoxin2_C  Glutaredoxin 2, C terminal domain


Domain annotation for each model (and alignments):
>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.3   0.0   5.9e-16   1.8e-12      28      93 .]      24      95 ..      18      95 .. 0.92

  Alignments for each domain:
  == domain 1  score: 47.3 bits;  conditional E-value: 5.9e-16
                HHHHHHHHHHHHHHHH..TSSSSSTTSSCHHHHHHHHHHHHHHHHTTTTT....TTTSHHHHHHHHHHHTSH CS
       GST_C 28 lekvaevlsaleeelk..kqdylvGdkltlADialvpilnwlqrlglafg....qekfpnlkawlerimarp 93
                l+++ +   +le++l+  +++y++Gd++t+AD a++p+l++l+ +g  ++     e +p++ka+++r+ +rp
  EFC38106.1 24 LKETQRLWGVLEKHLAegDKKYIIGDEYTIADMAIFPWLRVLPFYGEPVVeqfkWETYPHIKAYIDRVGERP 95
                678889999*******************************999999888888889*************9998 PP

>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.9   0.0   1.6e-15   4.8e-12      23      94 ..      21      99 ..       7     102 .. 0.87

  Alignments for each domain:
  == domain 1  score: 45.9 bits;  conditional E-value: 1.6e-15
                HHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHH......TCC..CC-HHHHHHHHHHHTSHHHHH CS
     GST_C_3 23 efleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleea......eal..kkfpklkalyervearpkika 94
                e + ++ ++ ++++ek+l++  ++y++gd+ T+AD+a+f +l  l +       +    +++p++ka+++rv +rp++++
  EFC38106.1 21 ERYLKETQRLWGVLEKHLAEGDKKYIIGDEYTIADMAIFPWLRVLPFYgepvveQ-FkwETYPHIKAYIDRVGERPAVQK 99
                55556778999********66666*************************998743.3689*****************986 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.9   0.0   2.5e-14   7.4e-11       4      69 .]      20      90 ..      17      90 .. 0.92

  Alignments for each domain:
  == domain 1  score: 41.9 bits;  conditional E-value: 2.5e-14
                HCHHHHHCCHCHHHCTTT---SS...CTTCS--HHHHHHHHHHHHHHHHHHS-...---TT-HHHHHHHHH CS
     GST_C_2  4 veraleqldaaldaleahLadsp..flfGdqptlaDialapflvrlraagpgf...direaypnlraWler 69
                +er l++ ++   +le+hLa ++  ++ Gd+ t+aD a +p+l  l ++g++      +e yp+++a+++r
  EFC38106.1 20 KERYLKETQRLWGVLEKHLAEGDkkYIIGDEYTIADMAIFPWLRVLPFYGEPVveqFKWETYPHIKAYIDR 90
                6889999*************9999**********************99988888878889*********98 PP

>> GST_C_6  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   3.5e-06      0.01       8      64 .]      34      91 ..      20      91 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 3.5e-06
     GST_C_6  8 LselL..gdkkyFfGdkPtslDAlvFGhlaqilytplespelrellk..eypNLvayceri 64
                L + L  gdkky+ Gd+ t +D ++F  l  +    +++p   e  k   yp + ay++r+
  EFC38106.1 34 LEKHLaeGDKKYIIGDEYTIADMAIFPWLRVL--PFYGEP-VVEQFKweTYPHIKAYIDRV 91
                66777779********************9999..455677.55555558999999999996 PP

>> GST_C_5  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   3.8e-05      0.11      32      72 ..      26      64 ..       4      99 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.8e-05
                HHHHHHHHHHHHHCCHTSSSSECCECC--HHHHHHHHHHHH CS
     GST_C_5 32 elddnaayledllakhqgeGPyfldkelsmadvavvPflvr 72
                e +   + le+ la+  g+  y +++e+++ad+a+ P+l  
  EFC38106.1 26 ETQRLWGVLEKHLAE--GDKKYIIGDEYTIADMAIFPWLRV 64
                444445556666654..6778*****************954 PP

>> Glutaredoxin2_C  Glutaredoxin 2, C terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   7.8e-05      0.23      77     121 ..      43      95 ..      17      99 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 7.8e-05
  Glutaredoxin2_C  77 seavng.elSvdDillfpiLrsLt.....lvkglefp..pkvraYldevsekt 121
                      ++++ g e++++D+ +fp Lr L      +v++ ++   p+++aY+d+v e+ 
       EFC38106.1  43 KKYIIGdEYTIADMAIFPWLRVLPfygepVVEQFKWEtyPHIKAYIDRVGERP 95 
                      3344445999*************633333788888874469999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (107 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       235  (0.0131073); expected 358.6 (0.02)
Passed bias filter:                      228  (0.0127168); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 652.70
//
Query:       EFC38107.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.8e-18   66.6   0.0    2.4e-18   66.2   0.0    1.2  1  GST_N       Glutathione S-transferase, N-terminal domain
    5.2e-15   55.6   0.0    6.3e-15   55.4   0.0    1.1  1  GST_N_3     Glutathione S-transferase, N-terminal domain
    4.1e-14   52.6   0.0      5e-14   52.3   0.0    1.1  1  GST_N_2     Glutathione S-transferase, N-terminal domain
  ------ inclusion threshold ------
       0.11   13.0   0.0       0.16   12.4   0.0    1.3  1  PSII_Pbs31  Photosystem II Psb31 protein


Domain annotation for each model (and alignments):
>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.2   0.0   5.5e-22   2.4e-18       4      75 ..       3      75 ..       1      76 [. 0.96

  Alignments for each domain:
  == domain 1  score: 66.2 bits;  conditional E-value: 5.5e-22
                EEESSSTSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTTS-SSEEEET..TEEEESHHHHHHHHH CS
       GST_N  4 tlysirgsprahrirlllaakgveyevvpldfeageekspellklnplgkvPaLedn..gkkltESraIleYia 75
                 lys  + p+ h+i ++l++ g+ey+   +d  +ge+ spe+lk+ p+ k+Pa +d+  g+ l+ES+aIl+Y+a
  EFC38107.1  3 DLYSLAT-PNGHKIAIALEEMGLEYKAHTIDIRKGEQFSPEFLKISPNNKIPAIVDQenGLALFESGAILQYLA 75
                5888888.9****************************************************************8 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.4   0.0   1.4e-18   6.3e-15       2      72 ..       5      79 ..       4      87 .. 0.87

  Alignments for each domain:
  == domain 1  score: 55.4 bits;  conditional E-value: 1.4e-18
                ES-TTSHHHHHHHHHHHHHT--EEEE---..TTTT.HHHHHHH-TT--SSEEETT..S-EEESHHHHHHHHHHHH- CS
     GST_N_3  2 ygfpaSpyarrvrlaLnekglpvevvevt..pgeh.deellaknplgkvPvLedd..gealtdSlaIidyLeelyp 72
                y+  + p+  ++++aL+e gl+++ + ++  +ge  ++e+l+++p++k+P+++d+  g al++S aI++yL ++ +
  EFC38107.1  5 YSLAT-PNGHKIAIALEEMGLEYKAHTIDirKGEQfSPEFLKISPNNKIPAIVDQenGLALFESGAILQYLADKSG 79
                55544.9*****************887765588889****************8766699************99865 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.3   0.0   1.1e-17     5e-14       3      69 ..      10      76 ..       8      77 .. 0.93

  Alignments for each domain:
  == domain 1  score: 52.3 bits;  conditional E-value: 1.1e-17
                HHHHHHHHHHHHCT--EEEEEEH...-TTSHHHHHHHHCTTTSSSEEE-C.TTEEEESHHHHHHHHHH CS
     GST_N_2  3 PwahRvlialalkglediisvvvlepkgfekseefprlnprgtVPvLwdk.dgqvineSseIlrylet 69
                P  h++ ial+++gle++ + + + +kg++ s+ef++++p+ ++P+++d  +g  + eS +Il+yl++
  EFC38107.1 10 PNGHKIAIALEEMGLEYKAHTI-DIRKGEQFSPEFLKISPNNKIPAIVDQeNGLALFESGAILQYLAD 76
                889***************9999.669***********************86888************86 PP

>> PSII_Pbs31  Photosystem II Psb31 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.6e-05      0.16      28      56 ..      50      79 ..      43      93 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.6e-05
  PSII_Pbs31 28 GdfaavveeknaftLFnsGay.ksaadKak 56
                  + a+v+++n + LF sGa+ +  adK+ 
  EFC38107.1 50 NKIPAIVDQENGLALFESGAIlQYLADKSG 79
                56789***************9766777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       239  (0.0133304); expected 358.6 (0.02)
Passed bias filter:                      230  (0.0128284); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.48
# Mc/sec: 655.56
//
Query:       EFC38108.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.6e-28   95.6   2.3    4.4e-05   23.1   0.0    6.5  6  TPR_1       Tetratricopeptide repeat
    1.4e-21   74.8   0.3      0.018   15.1   0.0    7.1  7  TPR_2       Tetratricopeptide repeat
    6.4e-16   57.8   5.3    8.4e-05   22.2   0.0    6.1  6  TPR_11      TPR repeat
      2e-12   46.3   6.8       0.11   12.7   0.1    7.0  7  TPR_8       Tetratricopeptide repeat
    4.2e-11   42.7   0.1        3.1    8.6   0.0    6.8  8  TPR_6       Tetratricopeptide repeat
    5.7e-09   35.8   3.5      0.009   16.3   0.0    5.3  6  TPR_17      Tetratricopeptide repeat
    1.3e-07   31.6   0.0      0.015   15.4   0.0    4.2  4  TPR_9       Tetratricopeptide repeat
     0.0003   21.4   0.0       0.11   13.1   0.0    3.7  4  TPR_16      Tetratricopeptide repeat
    0.00032   20.9   0.5         13    6.2   0.1    4.8  6  TPR_12      Tetratricopeptide repeat
    0.00053   19.8   1.4       0.08   13.0   0.0    4.4  4  TPR_7       Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.17   12.0   2.8         18    5.5   0.0    3.8  4  Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
       0.69   10.1   5.0        1.1    9.5   5.0    1.3  1  GAGA_bind   GAGA binding protein-like family
          8    5.1  10.3         11    4.7  10.3    1.1  1  Presenilin  Presenilin


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   2.4e-06    0.0033      11      33 ..      14      36 ..       5      37 .. 0.89
   2 !   18.7   0.0   7.7e-07    0.0011       4      34 .]      40      70 ..      37      70 .. 0.95
   3 !   11.4   0.0   0.00016      0.22       2      29 ..      72      99 ..      71     100 .. 0.96
   4 !   11.7   0.0   0.00013      0.18       2      31 ..     139     168 ..     138     171 .. 0.93
   5 !    7.2   0.0    0.0035       4.8       7      34 .]     182     209 ..     178     209 .. 0.94
   6 !   23.1   0.0   3.2e-08   4.4e-05       3      34 .]     212     243 ..     210     243 .. 0.97

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 2.4e-06
                HHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1 11 yfklgkydeAleyyekALelnPn 33
                +f+ ++y +A+ey+ k++el++n
  EFC38108.1 14 FFNEQDYSKAVEYFTKVIELEEN 36
                7999****************987 PP

  == domain 2  score: 18.7 bits;  conditional E-value: 7.7e-07
                HHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1  4 lynlGnayfklgkydeAleyyekALelnPnn 34
                +y+++ a+  l + ++A+++y+k++el++++
  EFC38108.1 40 YYQRATAFGCLLDRKKAIDDYSKVIELDETF 70
                9***************************986 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 0.00016
                HHHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1  2 kalynlGnayfklgkydeAleyyekALe 29
                +a+  +G+ +fk +++++A  +++k++e
  EFC38108.1 72 DAYLYRGLNLFKIEDFKKADSDFSKVIE 99
                79************************98 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 0.00013
                 HHHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekALeln 31 
                 +al+ +G++ + l ++ +A+ +  +++el 
  EFC38108.1 139 QALFHRGLTNRILDNLSDAISDLTRVIELS 168
                 79**************************96 PP

  == domain 5  score: 7.2 bits;  conditional E-value: 0.0035
                 HHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   7 lGnayfklgkydeAleyyekALelnPnn 34 
                 +G  y  l++ ++ +++ + ++el+ nn
  EFC38108.1 182 RGKFYALLEENEKSVQDLSDVIELDSNN 209
                 8999*********************998 PP

  == domain 6  score: 23.1 bits;  conditional E-value: 3.2e-08
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 a+y +G a++kl++ ++A+ + +k+ el+P+n
  EFC38108.1 212 AFYYRGFAFQKLNQNEKAVHDHSKVKELDPDN 243
                 89****************************98 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   1.3e-05     0.018       8      33 ..      11      36 ..       5      37 .. 0.88
   2 !   10.8   0.0   0.00032      0.44       4      33 ..      40      69 ..      37      70 .. 0.91
   3 !   10.8   0.0   0.00031      0.43       2      29 ..      72      99 ..      71     103 .. 0.94
   4 ?    1.2   0.0      0.38   5.3e+02       6      34 .]     109     137 ..     106     137 .. 0.87
   5 !   10.8   0.0   0.00031      0.43       2      34 .]     139     171 ..     138     171 .. 0.93
   6 ?    4.4   0.0     0.035        48       5      34 .]     180     209 ..     178     209 .. 0.92
   7 !   12.1   0.0   0.00012      0.16       3      34 .]     212     243 ..     210     243 .. 0.95

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.3e-05
       TPR_2  8 GlayyklgdyeeAleafekAleldPn 33
                G+  ++ +dy +A+e+f k++el++n
  EFC38108.1 11 GRKFFNEQDYSKAVEYFTKVIELEEN 36
                6778999****************987 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00032
       TPR_2  4 lynlGlayyklgdyeeAleafekAleldPn 33
                +y+++ a   l d ++A++++ k++eld++
  EFC38108.1 40 YYQRATAFGCLLDRKKAIDDYSKVIELDET 69
                899999999999***************986 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 0.00031
       TPR_2  2 ealynlGlayyklgdyeeAleafekAle 29
                +a+ ++Gl ++k  d+++A  +f k++e
  EFC38108.1 72 DAYLYRGLNLFKIEDFKKADSDFSKVIE 99
                689**********************997 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.38
       TPR_2   6 nlGlayyklgdyeeAleafekAleldPnn 34 
                 ++G + ++  + +eAl++++  +e +P++
  EFC38108.1 109 YRGISRIRIRKENEALDDLNVFIEKEPDH 137
                 789999999999*******9999999986 PP

  == domain 5  score: 10.8 bits;  conditional E-value: 0.00031
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                 +al+ +Gl  + l+++ +A+ ++ +++el  +n
  EFC38108.1 139 QALFHRGLTNRILDNLSDAISDLTRVIELSNEN 171
                 69***************************8765 PP

  == domain 6  score: 4.4 bits;  conditional E-value: 0.035
       TPR_2   5 ynlGlayyklgdyeeAleafekAleldPnn 34 
                   +G+ y+ l + e+ ++++  ++eld nn
  EFC38108.1 180 EKRGKFYALLEENEKSVQDLSDVIELDSNN 209
                 57999**********************997 PP

  == domain 7  score: 12.1 bits;  conditional E-value: 0.00012
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPnn 34 
                 a y++G a  kl++ e+A+++  k+ eldP+n
  EFC38108.1 212 AFYYRGFAFQKLNQNEKAVHDHSKVKELDPDN 243
                 89****************************97 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.1    0.0048       6.6       1      31 [.      11      41 ..      11      47 .. 0.90
   2 !   17.0   0.0   2.5e-06    0.0035      12      39 ..      55      82 ..      53      84 .. 0.90
   3 ?    0.7   0.0      0.32   4.4e+02      12      37 ..     122     147 ..     121     148 .. 0.80
   4 ?    2.3   0.0     0.095   1.3e+02       9      30 ..     153     174 ..     149     175 .. 0.88
   5 !   22.2   0.0   6.1e-08   8.4e-05       3      41 ..     185     223 ..     183     224 .. 0.92
   6 !    6.7   0.0    0.0043       5.9       7      32 ..     223     248 ..     222     249 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0048
      TPR_11  1 GdayyeqGkyeeAieaYkkAlkldPdnaeay 31
                G+ ++  ++y +A+e + k ++l ++  + y
  EFC38108.1 11 GRKFFNEQDYSKAVEYFTKVIELEENAMNYY 41
                7889999****************99987766 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 2.5e-06
      TPR_11 12 eAieaYkkAlkldPdnaeayynLGlayy 39
                +Ai +Y+k ++ld+++ +ay+ +Gl ++
  EFC38108.1 55 KAIDDYSKVIELDETFLDAYLYRGLNLF 82
                8***********************8555 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.32
      TPR_11  12 eAieaYkkAlkldPdnaeayynLGla 37 
                 eA+ +++  ++  Pd + a++++Gl+
  EFC38108.1 122 EALDDLNVFIEKEPDHVQALFHRGLT 147
                 6666666668999***********86 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.095
      TPR_11   9 kyeeAieaYkkAlkldPdnaea 30 
                 ++ +Ai ++ + ++l+++n ++
  EFC38108.1 153 NLSDAISDLTRVIELSNENDDL 174
                 6789***************986 PP

  == domain 5  score: 22.2 bits;  conditional E-value: 6.1e-08
      TPR_11   3 ayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayykq 41 
                  y  + ++e+++++++  ++ld++n+ a+y +G+a++k+
  EFC38108.1 185 FYALLEENEKSVQDLSDVIELDSNNVHAFYYRGFAFQKL 223
                 5777899******************************97 PP

  == domain 6  score: 6.7 bits;  conditional E-value: 0.0043
      TPR_11   7 qGkyeeAieaYkkAlkldPdnaeayy 32 
                 ++++e+A+ + +k  +ldPdn + y+
  EFC38108.1 223 LNQNEKAVHDHSKVKELDPDNRNSYH 248
                 79*******************88885 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.1   8.2e-05      0.11      12      33 ..      15      36 ..      11      37 .. 0.90
   2 ?    2.1   0.1      0.21   2.9e+02      18      28 ..      35      45 ..      34      47 .. 0.89
   3 ?    5.8   0.2     0.013        19      16      33 ..      52      69 ..      39      70 .. 0.81
   4 ?    4.7   0.0     0.031        43       3      29 ..      73      99 ..      71     100 .. 0.87
   5 !    8.1   0.0    0.0026       3.6       2      33 ..     139     170 ..     138     171 .. 0.93
   6 !    6.3   0.0    0.0095        13       6      34 .]     181     209 ..     178     209 .. 0.91
   7 ?    5.3   0.0     0.019        27       7      34 .]     216     243 ..     210     243 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 8.2e-05
                HHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8 12 lklgdyeeAkeyyekaleldpd 33
                ++ +dy +A+ey+ k++el+++
  EFC38108.1 15 FNEQDYSKAVEYFTKVIELEEN 36
                6789***************976 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.21
                HHHHHHHHHHH CS
       TPR_8 18 eeAkeyyekal 28
                e+A+ yy++a+
  EFC38108.1 35 ENAMNYYQRAT 45
                89******996 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.013
                -HHHHHHHHHHHHHHHHH CS
       TPR_8 16 dyeeAkeyyekaleldpd 33
                d ++A+  y k++eld++
  EFC38108.1 52 DRKKAIDDYSKVIELDET 69
                789************985 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.031
                HHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8  3 ayynlgsiylklgdyeeAkeyyekale 29
                ay+  g+ ++k +d+++A + + k++e
  EFC38108.1 73 AYLYRGLNLFKIEDFKKADSDFSKVIE 99
                6777889999**************998 PP

  == domain 5  score: 8.1 bits;  conditional E-value: 0.0026
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 +a+++ g++ + l ++  A++ + +++el+ +
  EFC38108.1 139 QALFHRGLTNRILDNLSDAISDLTRVIELSNE 170
                 799**************************987 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.0095
                 HHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   6 nlgsiylklgdyeeAkeyyekaleldpdn 34 
                 + g+ y  l++ e++++ +  ++eld +n
  EFC38108.1 181 KRGKFYALLEENEKSVQDLSDVIELDSNN 209
                 67999*********************986 PP

  == domain 7  score: 5.3 bits;  conditional E-value: 0.019
                 HHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   7 lgsiylklgdyeeAkeyyekaleldpdn 34 
                  g + +kl++ e+A+    k+ eldpdn
  EFC38108.1 216 RGFAFQKLNQNEKAVHDHSKVKELDPDN 243
                 678899********************97 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0    0.0022       3.1      11      28 ..      15      32 ..      11      34 .. 0.85
   2 ?   -0.9   0.0       2.4   3.3e+03      17      26 ..      35      44 ..      33      47 .. 0.82
   3 ?    1.4   0.1      0.46   6.3e+02       3      28 ..      40      65 ..      37      66 .. 0.79
   4 ?    6.5   0.0     0.011        15       1      28 [.      72      99 ..      72      99 .. 0.92
   5 !    8.2   0.0    0.0032       4.4       3      33 .]     107     137 ..     106     137 .. 0.90
   6 ?    1.6   0.0      0.39   5.4e+02       1      28 [.     139     166 ..     139     167 .. 0.86
   7 ?   -1.5   0.0       3.7   5.1e+03       5      28 ..     181     204 ..     178     208 .. 0.79
   8 ?    6.0   0.0     0.016        22       2      20 ..     212     230 ..     211     242 .. 0.93

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0022
                HH.HHHHHHHHHHHHHHHH CS
       TPR_6 11 rk.lgdtdkAlealerlik 28
                ++ + d++kA+e++ ++i+
  EFC38108.1 15 FNeQ-DYSKAVEYFTKVIE 32
                5525.************97 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 2.4
                HHHHHHHHHH CS
       TPR_6 17 dkAlealerl 26
                ++A+ +++r 
  EFC38108.1 35 ENAMNYYQRA 44
                6899999986 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.46
                HHHHHHHHH.HHHHHHHHHHHHHHHHH CS
       TPR_6  3 lyklalsyr.klgdtdkAlealerlik 28
                +y++a ++   l d  kA++ + ++i+
  EFC38108.1 40 YYQRATAFGcLL-DRKKAIDDYSKVIE 65
                577777777667.89999999999997 PP

  == domain 4  score: 6.5 bits;  conditional E-value: 0.011
                HHHHHHHHHHHH.HHHHHHHHHHHHHHHH CS
       TPR_6  1 dAlyklalsyrk.lgdtdkAlealerlik 28
                dA+++++l ++k   d  kA   + ++i+
  EFC38108.1 72 DAYLYRGLNLFKiE-DFKKADSDFSKVIE 99
                8***********55.*********99996 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.0032
                 HHHHHHHHHHHHHHHHHHHHHHHHHHH-TT- CS
       TPR_6   3 lyklalsyrklgdtdkAlealerlikeYPdS 33 
                 +++++ s+++  +  +Al+ l+ +i++ Pd+
  EFC38108.1 107 FLYRGISRIRIRKENEALDDLNVFIEKEPDH 137
                 6899******66999**************96 PP

  == domain 6  score: 1.6 bits;  conditional E-value: 0.39
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrklgdtdkAlealerlik 28 
                 +Al++++l  r l++ ++A+  l r+i+
  EFC38108.1 139 QALFHRGLTNRILDNLSDAISDLTRVIE 166
                 699999998886779999*999999997 PP

  == domain 7  score: -1.5 bits;  conditional E-value: 3.7
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealerlik 28 
                 k+++ y  l + +k+++ l ++i+
  EFC38108.1 181 KRGKFYALLEENEKSVQDLSDVIE 204
                 677778887799999999999987 PP

  == domain 8  score: 6.0 bits;  conditional E-value: 0.016
                 HHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAl 20 
                 A+y+++ +++kl++ +kA+
  EFC38108.1 212 AFYYRGFAFQKLNQNEKAV 230
                 99*********99****97 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.43   5.9e+02      11      23 ..      35      47 ..      26      56 .. 0.83
   2 !    7.3   0.0     0.005       6.9       2      32 ..      60      90 ..      59      92 .. 0.92
   3 !    6.8   0.0    0.0071       9.8       5      33 ..     130     158 ..     128     159 .. 0.88
   4 ?   -1.7   0.0       3.7   5.1e+03      14      30 ..     177     193 ..     162     197 .. 0.64
   5 !   16.3   0.0   6.5e-06     0.009       5      33 ..     202     230 ..     199     231 .. 0.94
   6 ?   -2.3   0.1       5.7   7.9e+03       7      17 ..     238     248 ..     238     249 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.43
      TPR_17 11 nnadaynnLAell 23
                 na  y+++A+++
  EFC38108.1 35 ENAMNYYQRATAF 47
                5899999999986 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.005
      TPR_17  2 ylkaleldPnnadaynnLAelllknGdlmtA 32
                y k++eld +  day +++  l k+ d+++A
  EFC38108.1 60 YSKVIELDETFLDAYLYRGLNLFKIEDFKKA 90
                889****************999999998887 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0071
      TPR_17   5 aleldPnnadaynnLAelllknGdlmtAr 33 
                 ++e++P+++ a++ ++ + + + +l +A+
  EFC38108.1 130 FIEKEPDHVQALFHRGLTNRILDNLSDAI 158
                 69***************999888887775 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 3.7
      TPR_17  14 daynnLAelllknGdlm 30 
                 +++  ++++++ + + +
  EFC38108.1 177 VSLEKRGKFYALLEENE 193
                 56677888888666555 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 6.5e-06
      TPR_17   5 aleldPnnadaynnLAelllknGdlmtAr 33 
                 ++eld nn+ a+++++ ++ k+++ ++A+
  EFC38108.1 202 VIELDSNNVHAFYYRGFAFQKLNQNEKAV 230
                 79***********************9995 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 5.7
      TPR_17   7 eldPnnadayn 17 
                 eldP+n ++y+
  EFC38108.1 238 ELDPDNRNSYH 248
                 789**978776 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.22   3.1e+02       7      61 ..      16      69 ..      14      78 .. 0.77
   2 ?    1.2   0.0      0.31   4.3e+02      13      57 ..      55      99 ..      50     105 .. 0.78
   3 !   15.4   0.0   1.1e-05     0.015      12      64 ..     121     173 ..     113     178 .. 0.89
   4 !    7.9   0.0    0.0025       3.4      10      63 ..     191     244 ..     182     248 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.22
       TPR_9  7 reedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapd 61
                +e+d+++a ++   ++ l  ++   ++ R+ +   l + ++A++d    ++l++ 
  EFC38108.1 16 NEQDYSKAVEYFTKVIELEENA-MNYYQRATAFGCLLDRKKAIDDYSKVIELDET 69
                6888888888888888888765.77888888888888888899988888888775 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.31
       TPR_9 13 ralavverllllaPddpeerrdRGlllaqlGclsaAladLeayla 57
                +a+  +  ++ l+    + ++ RGl l++ +++++A  d+   ++
  EFC38108.1 55 KAIDDYSKVIELDETFLDAYLYRGLNLFKIEDFKKADSDFSKVIE 99
                566666667777777778888899999999999999999987665 PP

  == domain 3  score: 15.4 bits;  conditional E-value: 1.1e-05
       TPR_9  12 eralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapd 64 
                  +al  ++  +   Pd+++ ++ RGl +  l++ls A+ dL + ++l+ +++d
  EFC38108.1 121 NEALDDLNVFIEKEPDHVQALFHRGLTNRILDNLSDAISDLTRVIELSNENDD 173
                 56888888889999*******************************99987776 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0025
       TPR_9  10 dweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdap 63 
                 ++e+  + +  ++ l+++ ++  + RG++ ++l++ ++A+ d     +l+pd++
  EFC38108.1 191 ENEKSVQDLSDVIELDSNNVHAFYYRGFAFQKLNQNEKAVHDHSKVKELDPDNR 244
                 566666666778999**************************9888888888766 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.46   6.3e+02       7      27 ..      14      34 ..       9      47 .. 0.74
   2 ?    1.1   0.0      0.48   6.6e+02      15      53 ..      55      90 ..      41      90 .. 0.76
   3 !   13.1   0.0   8.2e-05      0.11       9      58 ..     116     163 ..     110     171 .. 0.82
   4 ?   -0.3   0.0       1.3   1.8e+03      20      53 ..     199     229 ..     190     232 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.46
      TPR_16  7 alragdyddAaaaleaalkrd 27
                +++ +dy +A+++++ ++++ 
  EFC38108.1 14 FFNEQDYSKAVEYFTKVIELE 34
                667778888888888777765 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.48
      TPR_16 15 dAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeA 53
                +A+  +  ++++d       +A+l++g+ +++  ++++A
  EFC38108.1 55 KAIDDYSKVIELDET---FLDAYLYRGLNLFKIEDFKKA 90
                577777777777744...446*******99998888877 PP

  == domain 3  score: 13.1 bits;  conditional E-value: 8.2e-05
      TPR_16   9 ragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAa.alyr 58 
                 r ++  +A+  l+ ++++    Pd+++Al+++g+    + +l +A+ +l r
  EFC38108.1 116 RIRKENEALDDLNVFIEKE---PDHVQALFHRGLTNRILDNLSDAIsDLTR 163
                 5566678888888899999...************************55544 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 1.3
      TPR_16  20 leaalkrdpssPdaaeAllllgdaalrqgrlaeA 53 
                 l  ++++d   + +++A +++g a+ +++  ++A
  EFC38108.1 199 LSDVIELD---SNNVHAFYYRGFAFQKLNQNEKA 229
                 66677777...88999******998766666655 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.049        68      17      74 ..      18      33 ..       5      36 .. 0.66
   2 !    6.2   0.1    0.0091        13      17      55 ..      18      47 ..      14      69 .. 0.54
   3 ?   -0.6   0.0       1.2   1.7e+03       5      31 ..      73      99 ..      69     100 .. 0.71
   4 ?    5.9   0.0     0.012        16      41      75 ..     134     168 ..     122     170 .. 0.85
   5 ?   -0.9   0.0       1.6   2.1e+03       7      33 ..     180     206 ..     177     212 .. 0.83
   6 ?    0.9   0.0      0.41   5.6e+02       7      32 ..     214     239 ..     210     253 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.049
      TPR_12 17 grydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74
                +                                          +y +A+e++++++++
  EFC38108.1 18 Q------------------------------------------DYSKAVEYFTKVIEL 33
                3..........................................566666666665554 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0091
      TPR_12 17 grydeAlellekaleiarrllGpdhpltattlrnLgrly 55
                ++y +A e++ k++e+ +++           ++  ++++
  EFC38108.1 18 QDYSKAVEYFTKVIELEENA---------MNYYQRATAF 47
                56666666666666666544.........4444444444 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 1.2
      TPR_12  5 alnnlaavlrrlgrydeAlellekale 31
                a+  +++ l++ +++ +A + + k++e
  EFC38108.1 73 AYLYRGLNLFKIEDFKKADSDFSKVIE 99
                555577778888888888888877765 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.012
      TPR_12  41 hpltattlrnLgrlyralgryeeAlelleealaia 75 
                  p+ +++l+  g + r l+++ +A++ l++++++ 
  EFC38108.1 134 EPDHVQALFHRGLTNRILDNLSDAISDLTRVIELS 168
                 4566999***********************99985 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 1.6
      TPR_12   7 nnlaavlrrlgrydeAlellekaleia 33 
                  +++ +++ l++ +++ + l  ++e+ 
  EFC38108.1 180 EKRGKFYALLEENEKSVQDLSDVIELD 206
                 468999999999***999999998876 PP

  == domain 6  score: 0.9 bits;  conditional E-value: 0.41
      TPR_12   7 nnlaavlrrlgrydeAlellekalei 32 
                 + ++ + ++l + ++A   + k+ e+
  EFC38108.1 214 YYRGFAFQKLNQNEKAVHDHSKVKEL 239
                 468999999*******9999998877 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.0   5.8e-05      0.08       9      29 ..      14      34 ..       6      39 .. 0.83
   2 ?    1.5   0.1      0.27   3.8e+02      14      29 ..      52      67 ..      35      74 .. 0.59
   3 ?   -1.2   0.0         2   2.7e+03      14      31 ..     153     170 ..     149     174 .. 0.74
   4 ?   -0.3   0.0         1   1.4e+03       8      24 ..     219     235 ..     213     245 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 5.8e-05
       TPR_7  9 ysrlGdyeeAielyeqsLalt 29
                +++++dy++A+e+++++++l+
  EFC38108.1 14 FFNEQDYSKAVEYFTKVIELE 34
                6789************76665 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.27
       TPR_7 14 dyeeAielyeqsLalt 29
                d+++Ai+ y ++++l+
  EFC38108.1 52 DRKKAIDDYSKVIELD 67
                5666666666655554 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 2
       TPR_7  14 dyeeAielyeqsLaltkd 31 
                 + ++Ai+ ++++++l ++
  EFC38108.1 153 NLSDAISDLTRVIELSNE 170
                 567899999997777655 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 1
       TPR_7   8 lysrlGdyeeAielyeq 24 
                 ++++l++ e+A+  + +
  EFC38108.1 219 AFQKLNQNEKAVHDHSK 235
                 68999******976666 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.1     0.075     1e+02      15      33 ..      18      36 ..      15      40 .. 0.87
   2 ?    5.5   0.0     0.013        18       7      38 ..     110     141 ..     106     151 .. 0.87
   3 ?   -2.7   0.0       4.7   6.5e+03      31      45 ..     190     204 ..     188     206 .. 0.82
   4 ?    0.6   0.1      0.45   6.2e+02       4      36 ..     213     245 ..     211     247 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.075
                T-HHHHHHHHHHHHHHTTS CS
  Fis1_TPR_C 15 geYseArryvdalLeiEPe 33
                ++Ys+A +y   ++e+E +
  EFC38108.1 18 QDYSKAVEYFTKVIELEEN 36
                69*************9965 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.013
                 HHHHHHHHT-HHHHHHHHHHHHHHTTS-HHHH CS
  Fis1_TPR_C   7 lAlGhyklgeYseArryvdalLeiEPenrQaq 38 
                   +  +++++ +eA+  ++ ++e+EP+  Qa+
  EFC38108.1 110 RGISRIRIRKENEALDDLNVFIEKEPDHVQAL 141
                 5666778888899*****************97 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 4.7
                 TTS-HHHHHHHHHHH CS
  Fis1_TPR_C  31 EPenrQaqsLkelie 45 
                 E + + +q+L+ +ie
  EFC38108.1 190 EENEKSVQDLSDVIE 204
                 667789999*99998 PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.45
                 HHHHHHHHHHHT-HHHHHHHHHHHHHHTTS-HH CS
  Fis1_TPR_C   4 lYylAlGhyklgeYseArryvdalLeiEPenrQ 36 
                  Yy  ++  kl + ++A      + e++P+nr+
  EFC38108.1 213 FYYRGFAFQKLNQNEKAVHDHSKVKELDPDNRN 245
                 699999999999999999999999999999985 PP

>> GAGA_bind  GAGA binding protein-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   5.0   0.00079       1.1      37     171 ..     193     301 ..     150     331 .. 0.47

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00079
   GAGA_bind  37 tkpllqernlalalsekkaalaerdaa.maflrrdaalaerekvlnvlpvnka...kalleednalaalqmlrplesqlqeaeapelekeevasselve 131
                 +k++ + ++++   s++ +a+  r  a  ++ ++++a++++ kv +  p n++   +     +  la+++    ++ + ++++ ++ e++e+ ++e ve
  EFC38108.1 193 EKSVQDLSDVIELDSNNVHAFYYRGFAfQKLNQNEKAVHDHSKVKELDPDNRNsyhE-----TLILAKMEN---SNVEIESSD-NREETREENEQENVE 282
                 333333333222334445555566633345556666666666555555544443321.....122222222...222222222.233333333344444 PP

   GAGA_bind 132 esavvekeeaakkrqqgkrpkepkakkakkaarkpkeege 171
                 +s+ ++++e++k+ +++                      e
  EFC38108.1 283 NSPEKATQEESKETTETS---------------------E 301
                 444333333333222211.....................1 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7  10.3    0.0078        11     233     307 ..     237     309 ..     199     328 .. 0.38

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0078
  Presenilin 233 aeseeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaeesseekeseessesseeeee 307
                 +e + +++++ +++ +  + ++++ e ess+++++++  ee+++e+ ++++++a+++++++++e+s+++s+ +e+
  EFC38108.1 237 KELDPDNRNSYHETLILAKMENSNVEIESSDNREETR--EENEQENVENSPEKATQEESKETTETSEDESKVNED 309
                 2222222222222222222222222222222222222..222222222222222222222222222222222221 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2548  (0.142116); expected 358.6 (0.02)
Passed bias filter:                      772  (0.0430587); expected 358.6 (0.02)
Passed Vit filter:                       134  (0.00747392); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.51
# Mc/sec: 1961.98
//
Query:       EFC38109.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.32   11.1   3.4        9.7    6.3   2.2    2.3  2  NOT2_3_5  NOT2 / NOT3 / NOT5 family
          4    7.6   7.0       0.25   11.5   0.4    2.2  3  DUF2614   Zinc-ribbon containing domain


Domain annotation for each model (and alignments):
>> NOT2_3_5  NOT2 / NOT3 / NOT5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0    0.0066        59      38      57 ..      13      32 ..       2      34 .. 0.80
   2 ?    6.3   2.2    0.0011       9.7      53      98 ..      39      85 ..      37     115 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.0066
    NOT2_3_5 38 klesakklekldedtLFyiF 57
                + +++++l++l ++ LFy F
  EFC38109.1 13 SNNKKSILTNLRSNSLFYWF 32
                345889************99 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0011
    NOT2_3_5 53 LFyiFYysqgtleqllAakeLkkr.sWryhkelktWflreekeepke 98
                L y+FY++ + +e       L  r +W +   +k+W l +++ e+  
  EFC38109.1 39 LPYAFYHYVQIYESSWIHLTLGTRfGWGWMSSEKVWSLLHQMGEEGR 85
                569******************99669************997656544 PP

>> DUF2614  Zinc-ribbon containing domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.43   3.8e+03       9      23 ..      23      37 ..      16      60 .. 0.60
   2 ?   11.5   0.4   2.7e-05      0.25      20      76 ..      97     152 ..      85     159 .. 0.86
   3 ?   -1.3   0.3      0.26   2.3e+03      32      46 ..     175     189 ..     165     196 .. 0.61

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.43
     DUF2614  9 irtfalllvfigliv 23
                +r+ +l+  f gli+
  EFC38109.1 23 LRSNSLFYWFLGLIL 37
                455555555555554 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 2.7e-05
     DUF2614  20 glivmyigllfkeselllvlflllGlllvlastvvyfwiGllstkavqvvcpeceke 76 
                  ++v ++ l+ +  +  l + ll+Gl +vl s +  ++iG+l  +a+ ++  + eke
  EFC38109.1  97 FIVVAFVKLFWRFDKRALWVNLLFGL-FVLSSLMEKIMIGVLVHRALYMETAQGEKE 152
                 478999*******************7.578899999***********9999988886 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.26
     DUF2614  32 eselllvlflllGll 46 
                 +s++ +v+++++ ++
  EFC38109.1 175 KSDIWMVMMIIIDMI 189
                 444555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       867  (0.0483574); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1292.00
//
Query:       EFC38110.1  [L=1029]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-67  228.2   0.0    2.1e-67  227.3   0.0    1.5  1  Pkinase         Protein kinase domain
    2.5e-42  145.0   0.0    4.5e-42  144.1   0.0    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
      9e-07   28.5   0.0    4.1e-06   26.3   0.0    2.1  2  Kinase-like     Kinase-like
  ------ inclusion threshold ------
      0.032   14.4   0.0       0.12   12.6   0.0    1.9  1  DUF3782         Protein of unknown function (DUF3782)
      0.052   13.1   0.1       0.13   11.7   0.1    1.7  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  227.3   0.0   5.8e-71   2.1e-67       1     264 []     399     660 ..     399     660 .. 0.92

  Alignments for each domain:
  == domain 1  score: 227.3 bits;  conditional E-value: 5.8e-71
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH....HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS- CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke....kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgsl 95 
                 y+k   +G+G++GkV+ +++ ++gk +A+K+   ++  ++      ++++rEi+++k+l h+niv++y++  + ++l ++leyv+gg++ +ll+r g l
  EFC38110.1 399 YKKGDFIGSGASGKVFLGYNLDDGKFFAIKECTFDSVPEDILelklESLQREINLMKELCHENIVQYYGAEVTGTTLNIFLEYVPGGSVSSLLRRYGRL 497
                 678889*************************998877666555778***************************************************** PP

                 -HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS....BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHH CS
     Pkinase  96 seeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyel 190
                 se+ ++++++qil+gl+ylH+++i+HrD+K +NiL++ +g +K++DFG +++++   +    ++s  gt++++APEv+ ++++++++D+Ws+G++++e+
  EFC38110.1 498 SEDVVRHYTTQILKGLKYLHENRIVHRDIKGANILVSVEGAIKLADFGASRKIQDIMTlsteFKSLLGTPHFMAPEVIMQTGHGRSADIWSIGCTVVEM 596
                 ****************************************************9998777888************************************* PP

                 HHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 191 ltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 +tgkppf + ++             +++i   ++e    ++ +se +k++l k++ +dp+ R t+++ll++p++
  EFC38110.1 597 YTGKPPFTEFTTAA---------AVMFHIA-ASTEMPSFPEFVSEGCKKFLYKCFIRDPNLRATVDDLLNDPWI 660
                 ********322222.........2344444.346677788889******************************7 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  144.1   0.0   1.2e-45   4.5e-42       4     256 ..     402     655 ..     399     657 .. 0.88

  Alignments for each domain:
  == domain 1  score: 144.1 bits;  conditional E-value: 1.2e-45
                  EEEEEEESSEEEEEEEEET.TTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkg.ekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekl 100
                  g+ +G+Ga GkV+ g+  +  k  +  ++   ++ e+  e + e+l +e+++mk+l h+niv+++g+ + + +l i +eyv+gG++++ Lr+    +l
   EFC38110.1 402 GDFIGSGASGKVFLGYNLDdGKFFAIKECTFDSVPEDILELKLESLQREINLMKELCHENIVQYYGAEVTGTTLNIFLEYVPGGSVSSLLRRY--GRL 497
                  5679***********9984233344445555556678888889*************************************************8..99* PP

                  BHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEE.EETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHH CS
  Pkinase_Tyr 101 tlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddey.vkkeeaklpvkWmapEslkekkftsksDvWsfGvllwE 197
                  + + + ++++q+ kG++yL+++++vHrd+   N+L+s +  +k++DfG +r+i++  +  ++ ++     ++mapE+++++    ++D+Ws G ++ E
   EFC38110.1 498 SEDVVRHYTTQILKGLKYLHENRIVHRDIKGANILVSVEGAIKLADFGASRKIQDIMTLsTEFKSLLGTPHFMAPEVIMQTGHGRSADIWSIGCTVVE 595
                  *****************************************************776666344455567889*************************** PP

                  HHTTSSGTTTTS.HHHHHHHHHHTTEES-.BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 198 iftlgespypgl.kneevleklkegkrle.kpekcpeelyelmkkcweedpeeRptfselv 256
                  ++t g+ p++++ +++ v+ ++ ++++++  pe ++e  ++++ kc+ +dp+ R+t  +l+
   EFC38110.1 596 MYT-GKPPFTEFtTAAAVMFHIAASTEMPsFPEFVSEGCKKFLYKCFIRDPNLRATVDDLL 655
                  ***.********77888999997777776269999999******************99886 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.54   1.9e+03       7      68 ..     392     456 ..     389     464 .. 0.73
   2 !   26.3   0.0   1.2e-09   4.1e-06     143     270 ..     500     623 ..     488     640 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.54
  Kinase-like   7 lgerertlvrgellkkgdrsvvfevkdqetgeplavkvfllps...easkkdlerlkeqelairl 68 
                  +++  +++++g+ ++ g +++vf+  +   g+ +a+k  ++ s   +  + +le l+++  ++++
   EFC38110.1 392 KEKTIKNYKKGDFIGSGASGKVFLGYNLDDGKFFAIKECTFDSvpeDILELKLESLQREINLMKE 456
                  567778999999***********999999999999999887762113345666666666555555 PP

  == domain 2  score: 26.3 bits;  conditional E-value: 1.2e-09
  Kinase-like 143 tiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvl.sevekgfaPpEllgsrggytrknktkmthkldaWqlGlv 239
                  ++ r++ T q+++   +L+++ +vh +++  n+l   +g ++l +f+a ++  + + l  e +  +  p +++         +t    + d W +G +
   EFC38110.1 500 DVVRHY-TTQILKGLKYLHENRIVHRDIKGANILVSVEGAIKLADFGASRKIQDIMTLsTEFKSLLGTPHFMAPEVI----MQTGHGRSADIWSIGCT 592
                  566666.5689999*******************************************94455566788999999666....57888999********* PP

  Kinase-like 240 iyriwclklPltlateeakeewkfklckkip 270
                  +  ++  k P+t+ t  a   ++     ++p
   EFC38110.1 593 VVEMYTGKPPFTEFTTAAAVMFHIAASTEMP 623
                  **************99999888666655544 PP

>> DUF3782  Protein of unknown function (DUF3782)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   3.2e-05      0.12      31      72 ..     487     528 ..     485     530 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.2e-05
     DUF3782  31 igaLGaRWGlvsEeafReglkeiLeealgv.kVekwlyyDkeG 72 
                 +++L +R+G +sE+++R    +iL+   ++ + ++++++D +G
  EFC38110.1 487 VSSLLRRYGRLSEDVVRHYTTQILKGL-KYlHENRIVHRDIKG 528
                 678889*******************99.887888999999887 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   3.7e-05      0.13      75     156 ..     457     537 ..     437     558 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.7e-05
  YrbL-PhoP_reg  75 idnsplarilGlvqTdlGlGlvvekirdadGnvaktLedlvkkee.ltaelkeaLdefleelldnhivtndlsakNivvkkns 156
                         + +++G   T   l +  e +    G v+  L+++ +  e +  ++ +++ + l++l +n+iv +d++ +Ni+v  + 
     EFC38110.1 457 LCHENIVQYYGAEVTGTTLNIFLEYV--PGGSVSSLLRRYGRLSEdVVRHYTTQILKGLKYLHENRIVHRDIKGANILVSVEG 537
                    44556677777777655555555555..5689999***999865514558999999999*******************98665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1029 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2094  (0.116794); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.10u 0.35s 00:00:01.45 Elapsed: 00:00:00.54
# Mc/sec: 5715.96
//
Query:       EFC38111.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      6e-41  135.0  23.5      8e-06   25.5   0.2   11.0 11  LRR_6     Leucine Rich repeat
    3.8e-32  109.8  34.8    1.2e-07   31.4   4.3    5.1  7  LRR_8     Leucine rich repeat
    1.8e-20   72.7  27.7    0.00013   22.3   2.4    6.8  9  LRR_4     Leucine Rich repeats (2 copies)
    3.9e-11   41.9  17.0        3.7    8.5   0.0    9.9 10  LRR_1     Leucine Rich Repeat
    1.5e-05   24.5   1.2          1    8.9   0.3    3.2  3  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
      0.077   11.9   0.1       0.44    9.5   0.0    2.0  2  GGGtGRT   GGGtGRT protein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   6.7e-06      0.02       4      23 ..       3      22 ..       1      23 [. 0.87
   2 !   12.6   0.0   3.6e-05      0.11       5      24 .]      28      47 ..      26      47 .. 0.94
   3 !   10.1   0.0   0.00023      0.68       4      23 ..      51      70 ..      48      71 .. 0.88
   4 !   25.5   0.2   2.7e-09     8e-06       3      21 ..      74      92 ..      72      95 .. 0.89
   5 !   15.3   0.0   4.8e-06     0.014       4      22 ..      99     117 ..      96     119 .. 0.89
   6 !   13.2   0.1   2.4e-05     0.072       5      24 .]     124     143 ..     122     143 .. 0.88
   7 !   21.4   0.1   5.5e-08   0.00016       3      24 .]     146     167 ..     144     167 .. 0.92
   8 ?    4.0   0.0     0.022        64      12      24 .]     179     191 ..     168     191 .. 0.83
   9 ?    1.0   0.0      0.19   5.6e+02       4      24 .]     195     215 ..     192     215 .. 0.86
  10 !   16.9   0.0   1.5e-06    0.0045       4      24 .]     219     239 ..     216     239 .. 0.93
  11 !    7.6   0.0    0.0014       4.3       4      17 ..     243     256 ..     240     262 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 6.7e-06
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                 LteL+L +N++gDe a ++
  EFC38111.1  3 QLTELSLECNQLGDESAHKI 22
                69*************98666 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 3.6e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L +  N+Ig  Ga++++
  EFC38111.1 28 LTSLGVENNEIGPTGAKSIS 47
                9****************996 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.00023
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                 Lt+L+++ N +g eGa ++
  EFC38111.1 51 QLTSLNIKNNSVGVEGAHSI 70
                59**************9766 PP

  == domain 4  score: 25.5 bits;  conditional E-value: 2.7e-09
       LRR_6  3 thLteLdLsgNdIgDeGae 21
                t Lt+Ld+s N+IgDeGa+
  EFC38111.1 74 TRLTHLDISLNNIGDEGAK 92
                78***************98 PP

  == domain 5  score: 15.3 bits;  conditional E-value: 4.8e-06
       LRR_6   4 hLteLdLsgNdIgDeGaea 22 
                  Lt L++s+N+I+  G++ 
  EFC38111.1  99 QLTNLNISYNQITSNGMIP 117
                 59**************986 PP

  == domain 6  score: 13.2 bits;  conditional E-value: 2.4e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L  L++ +N Ig+eG+e ++
  EFC38111.1 124 LIILNVGSNRIGNEGIENIS 143
                 557*************9875 PP

  == domain 7  score: 21.4 bits;  conditional E-value: 5.5e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + LteLd+ g+d+g+eGa++++
  EFC38111.1 146 SQLTELDIGGCDFGNEGAKSIS 167
                 67*****************996 PP

  == domain 8  score: 4.0 bits;  conditional E-value: 0.022
       LRR_6  12 gNdIgDeGaeaLa 24 
                 +N+I  eGa++++
  EFC38111.1 179 SNNIREEGAKSIS 191
                 7*********996 PP

  == domain 9  score: 1.0 bits;  conditional E-value: 0.19
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 ++t L+L  N +  +Ga+ ++
  EFC38111.1 195 KVTCLNLCVNYLHADGAKHIS 215
                 689999999999999999885 PP

  == domain 10  score: 16.9 bits;  conditional E-value: 1.5e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt+L + +N+IgD+Gae L+
  EFC38111.1 219 QLTHLYMDSNEIGDDGAEDLC 239
                 59****************998 PP

  == domain 11  score: 7.6 bits;  conditional E-value: 0.0014
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +L+ L+++gN+I+ 
  EFC38111.1 243 NLKVLSIRGNNISY 256
                 8***********86 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.2   2.9e-06    0.0086      24      61 .]       1      38 [.       1      38 [. 0.95
   2 !   29.8   2.7   1.3e-10   3.7e-07       2      61 .]      27      86 ..      26      86 .. 0.98
   3 !   31.4   4.3     4e-11   1.2e-07       2      61 .]      51     110 ..      50     110 .. 0.98
   4 !   31.1   0.3     5e-11   1.5e-07       2      60 ..      99     157 ..      98     158 .. 0.95
   5 !   25.3   0.0   3.2e-09   9.6e-06       2      61 .]     171     230 ..     170     230 .. 0.97
   6 !   29.9   0.3   1.1e-10   3.4e-07       3      61 .]     196     254 ..     194     254 .. 0.96
   7 !    8.4   0.1   0.00061       1.8      23      39 ..     240     256 ..     238     267 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.9e-06
                -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8 24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +s+L++L+L +N+l   s++ +s++++L+sL +++N +
  EFC38111.1  1 MSQLTELSLECNQLGDESAHKISQFKQLTSLGVENNEI 38
                689*********************************86 PP

  == domain 2  score: 29.8 bits;  conditional E-value: 1.3e-10
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsL + nN +   + ++ +++++L++L+++nN+  +  ++++s++++L++Ld+s N++
  EFC38111.1 27 QLTSLGVENNEIGPTGAKSISTMKQLTSLNIKNNSVGVEGAHSISNMTRLTHLDISLNNI 86
                7*******************************************************9997 PP

  == domain 3  score: 31.4 bits;  conditional E-value: 4e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++ nN+  + + ++ +++++L++Ld+s N++    ++ + +L++L+ L++s+N++
  EFC38111.1  51 QLTSLNIKNNSVGVEGAHSISNMTRLTHLDISLNNIGDEGAKIICQLKQLTNLNISYNQI 110
                 7*********************************************************98 PP

  == domain 4  score: 31.1 bits;  conditional E-value: 5e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+L++s N++ts +   Fk +++L +L+ ++N++     + +sgL++L++Ld+ g++
  EFC38111.1  99 QLTNLNISYNQITSNGMIPFKEMKQLIILNVGSNRIGNEGIENISGLSQLTELDIGGCD 157
                 7***********************************998889*************9987 PP

  == domain 5  score: 25.3 bits;  conditional E-value: 3.2e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt L+ ++N++ + + ++ ++l++++ L+L  N l+   ++ +s++++L++L++++N +
  EFC38111.1 171 NLTCLYCCSNNIREEGAKSISQLEKVTCLNLCVNYLHADGAKHISQMKQLTHLYMDSNEI 230
                 8999999***************************************************87 PP

  == domain 6  score: 29.9 bits;  conditional E-value: 1.1e-10
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +t L+L+ N+l++ + +  +++++L++L++ +N++    ++ + gL++L+ L ++gN++
  EFC38111.1 196 VTCLNLCVNYLHADGAKHISQMKQLTHLYMDSNEIGDDGAEDLCGLENLKVLSIRGNNI 254
                 6679*****************************************************97 PP

  == domain 7  score: 8.4 bits;  conditional E-value: 0.00061
                 T-TT--EEE--SS---G CS
       LRR_8  23 glsnLkvLdLsnNlltt 39 
                 gl+nLkvL+++ N+++ 
  EFC38111.1 240 GLENLKVLSIRGNNISY 256
                 79999999999999986 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.1     7e-06     0.021       2      37 ..       3      39 ..       2      47 .. 0.87
   2 !    6.5   0.1    0.0039        12      21      34 ..      48      60 ..      41      67 .. 0.74
   3 !   17.3   1.7   1.6e-06    0.0049       1      36 [.      50      86 ..      50      90 .. 0.81
   4 !   22.3   2.4   4.3e-08   0.00013       1      38 [.      74     112 ..      74     120 .. 0.87
   5 !   19.8   1.6   2.7e-07   0.00079       1      37 [.      98     135 ..      98     144 .. 0.82
   6 !   14.4   0.2   1.3e-05      0.04       1      38 [.     122     157 ..     122     165 .. 0.82
   7 !   11.2   0.5   0.00013      0.39       1      30 [.     170     201 ..     170     209 .. 0.76
   8 !    8.4   0.0     0.001       3.1      19      37 ..     214     231 ..     194     235 .. 0.67
   9 !   16.7   0.2   2.4e-06    0.0073       1      34 [.     218     253 ..     218     258 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 7e-06
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37
                +L++L+L  Nql d +   ++++++L++L + +Nn i+
  EFC38111.1  3 QLTELSLECNQLGDESAhkISQFKQLTSLGV-ENNEIG 39
                79******99****99977668*********.777886 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0039
                H-TT--EEE-.-S- CS
       LRR_4 21 klpnLkeLdLsgNn 34
                 +++L++L++  Nn
  EFC38111.1 48 TMKQLTSLNI-KNN 60
                3999999999.554 PP

  == domain 3  score: 17.3 bits;  conditional E-value: 1.6e-06
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++L++ nN +   +   +++++ L++Ld+s N +i
  EFC38111.1 50 KQLTSLNIKNNSVGVEGAhsISNMTRLTHLDISLN-NI 86
                58************777776558********9546.45 PP

  == domain 4  score: 22.3 bits;  conditional E-value: 4.3e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld+s N++ d +   + +l++L+ L++s N +it+
  EFC38111.1  74 TRLTHLDISLNNIGDEGAkiICQLKQLTNLNISYN-QITS 112
                 68*******88****99986336*********999.8875 PP

  == domain 5  score: 19.8 bits;  conditional E-value: 2.7e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L++s Nq+t+ +   ++ +++L  L++ g n+i+
  EFC38111.1  98 KQLTNLNISYNQITSNGMipFKEMKQLIILNV-GSNRIG 135
                 58*************99986556*********.555875 PP

  == domain 6  score: 14.4 bits;  conditional E-value: 1.3e-05
                 SS--EEE--SS---E-S-HH..H-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitd 38 
                 ++L++L+ ++N++   +  +  +l +L+eLd+ g+    d
  EFC38111.1 122 KQLIILNVGSNRIGNEGIENisGLSQLTELDIGGC----D 157
                 589***********766644547*********887....5 PP

  == domain 7  score: 11.2 bits;  conditional E-value: 0.00013
                 SS--EEE--SS---E-S-..HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdL 30 
                 +nL+ L++ +N++++ +   +++l + + L+L
  EFC38111.1 170 TNLTCLYCCSNNIREEGAksISQLEKVTCLNL 201
                 7*************977765446777777887 PP

  == domain 8  score: 8.4 bits;  conditional E-value: 0.001
                 HHH-TT--EEE-.-S---- CS
       LRR_4  19 leklpnLkeLdLsgNnlit 37 
                 ++++++L++L++ +N  i+
  EFC38111.1 214 ISQMKQLTHLYMDSN-EIG 231
                 457*********666.665 PP

  == domain 9  score: 16.7 bits;  conditional E-value: 2.4e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++L+  +N + d +   l +l nLk+L++ gNn
  EFC38111.1 218 KQLTHLYMDSNEIGDDGAedLCGLENLKVLSIRGNN 253
                 58************855566558*********8895 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.051   1.5e+02       1      16 [.       3      18 ..       3      26 .. 0.78
   2 ?   -1.0   0.0       1.6   4.9e+03       2      13 ..      28      39 ..      27      48 .. 0.74
   3 ?    5.7   0.0      0.01        31       1      22 [.      51      72 ..      51      73 .. 0.86
   4 !    6.1   0.1    0.0073        22       1      20 [.      75      94 ..      75      97 .. 0.79
   5 ?    3.7   0.0     0.045   1.3e+02       2      13 ..     100     111 ..      99     119 .. 0.83
   6 ?    3.2   0.1     0.069   2.1e+02       2      22 ..     124     144 ..     123     145 .. 0.79
   7 !    8.5   0.0    0.0012       3.7       1      22 [.     147     168 ..     147     169 .. 0.87
   8 ?    1.1   0.8      0.33   9.9e+02       1      21 [.     171     191 ..     171     214 .. 0.76
   9 !    5.9   0.0    0.0089        27       1      23 []     219     241 ..     219     241 .. 0.89
  10 ?    5.7   0.0      0.01        31       1      12 [.     243     254 ..     243     271 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.051
       LRR_1  1 nLrhLdLsnnpllglp 16
                +L++L L+ n+l++ +
  EFC38111.1  3 QLTELSLECNQLGDES 18
                599********96554 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.6
       LRR_1  2 LrhLdLsnnpll 13
                L++L ++nn ++
  EFC38111.1 28 LTSLGVENNEIG 39
                899999999874 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.01
       LRR_1  1 nLrhLdLsnnpllglppnsfqn 22
                +L++L++ nn+ +  ++ s++n
  EFC38111.1 51 QLTSLNIKNNSVGVEGAHSISN 72
                599********98888888877 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0073
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                +L+hLd+s n++++ ++  +
  EFC38111.1 75 RLTHLDISLNNIGDEGAKII 94
                69*********987776655 PP

  == domain 5  score: 3.7 bits;  conditional E-value: 0.045
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L++s+n+++
  EFC38111.1 100 LTNLNISYNQIT 111
                 899******985 PP

  == domain 6  score: 3.2 bits;  conditional E-value: 0.069
       LRR_1   2 LrhLdLsnnpllglppnsfqn 22 
                 L  L++++n++++ +++ +++
  EFC38111.1 124 LIILNVGSNRIGNEGIENISG 144
                 889*******98777777665 PP

  == domain 7  score: 8.5 bits;  conditional E-value: 0.0012
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++Ld++++ +++ ++ s++ 
  EFC38111.1 147 QLTELDIGGCDFGNEGAKSISQ 168
                 599*********9999988875 PP

  == domain 8  score: 1.1 bits;  conditional E-value: 0.33
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL+ L+ ++n++   ++ s++
  EFC38111.1 171 NLTCLYCCSNNIREEGAKSIS 191
                 788899888887555555554 PP

  == domain 9  score: 5.9 bits;  conditional E-value: 0.0089
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L+hL++ +n +++ +++++++L
  EFC38111.1 219 QLTHLYMDSNEIGDDGAEDLCGL 241
                 59**********99999988876 PP

  == domain 10  score: 5.7 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L +++n++
  EFC38111.1 243 NLKVLSIRGNNI 254
                 8*********98 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.1   0.00034         1      61     144 ..      23     102 ..       3     104 .. 0.80
   2 !    8.9   0.3   0.00034         1      40     129 ..      96     183 ..      89     201 .. 0.69
   3 !    7.5   0.0    0.0009       2.7      59     126 ..     189     255 ..     177     262 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00034
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrl 144
                   +k+l +l ++nn i  ++ +   ++ +l++l + nn++     ++   s+++++ l+ l+ ++ n  +    +i +lkql+ 
  EFC38111.1  23 SQFKQLTSLGVENNEIGPTGAKSISTMKQLTSLNIKNNSVG----VEGAHSISNMTRLTHLDISLNNIGDEGAKIICQLKQLTN 102
                 4468899999*********9999999999999999999976....455678888888888888888888888999999999875 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00034
       LRR_9  40 tldqfdtidlsdndirkldgfPl..lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                  l q+  +++s n+i     +P+  +k+l +l + +nri + + +    l +l+el + +  + + +  + + +l +l++l   +n +   +
  EFC38111.1  96 QLKQLTNLNISYNQITSNGMIPFkeMKQLIILNVGSNRIGNEGIENISGLSQLTELDIGGCDFGNEGA-KSISQLTNLTCLYCCSNNI---R 183
                 57899999*******99888887668888899999999986555555568888888888887777665.5555555555555555544...3 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0009
       LRR_9  59 gfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 ++  l+++ +l l  n +   + +    + +l++l + +ne+ + +  + l  l++l++ls+  n ++
  EFC38111.1 189 SISQLEKVTCLNLCVNYLHADGAKHISQMKQLTHLYMDSNEIGDDGA-EDLCGLENLKVLSIRGNNIS 255
                 5667888899999999988888777788999*************998.99************999876 PP

>> GGGtGRT  GGGtGRT protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00015      0.44     130     180 ..      66     113 ..      52     142 .. 0.83
   2 ?    0.0   0.0      0.11   3.2e+02      98     170 ..     155     223 ..     128     231 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00015
     GGGtGRT 130 GaigiakkankvrkeplrvilnGlGkdaakiisrinGftyvetefdyktge 180
                 Ga    + +n +r + l + ln +G + akii++++ +t ++ +++  t++
  EFC38111.1  66 GAH---SISNMTRLTHLDISLNNIGDEGAKIICQLKQLTNLNISYNQITSN 113
                 443...4468899*****************************999988765 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.11
     GGGtGRT  98 GlGhGnlaamllseetkcfaflaGhesfaaaeGaigiakkankvrkeplrvilnGlGkdaakiisrinGftyv 170
                 G   Gn +a+ +s+ t+  ++    +     eGa  i++  +kv  + l++ +n l  d ak is+++ +t++
  EFC38111.1 155 GCDFGNEGAKSISQLTNLTCLYCCSNN-IREEGAKSISQ-LEKV--TCLNLCVNYLHADGAKHISQMKQLTHL 223
                 455677777777777777666665544.35677777764.4555..578888999999999999999988865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       456  (0.0254337); expected 358.6 (0.02)
Passed bias filter:                      306  (0.0170673); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1686.75
//
Query:       EFC38112.1  [L=565]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (565 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       639  (0.0356406); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 3770.24
//
Query:       EFC38113.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-24   87.1   0.2    2.9e-24   86.4   0.2    1.4  1  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.4   0.2   1.6e-28   2.9e-24      45     208 ..     283     457 ..     241     458 .. 0.76

  Alignments for each domain:
  == domain 1  score: 86.4 bits;  conditional E-value: 1.6e-28
      DUF563  45 kllgirpekrikveldepvhveklivpvpprssggfqgallp.klrdrlrerlnlekrkkptrvlyisR....lkagsRrilNeeevl.....kllpkr 133
                 ++++i  + +     ++ ++++k+i+++ + + + f+ + ++ +++ +l+ +++++  +++ +++y++R     ++g+R ilNe++vl     +ll+ r
  EFC38113.1 283 EIYQI-IAHNH--FHKRAIYAKKVIYSCRSPLVHPFTTQRISnEILFQLNLSFDIPFKDRK-KIVYFTRsngdSQNGGRMILNEDAVLehlkvELLK-R 376
                 33344.22233..223777788888888777666666655555999999999999996666.*******88777777**********9666655555.3 PP

      DUF563 134 g.......fevvdpeslsfeeqiklfssakvivgphGsgltnliFmppgttvielvppnrldns.fenlaallglkyayvlge 208
                 +       f+  d++  ++ e +k f+++k+i+gphG++++n+ F+p++ +v+e++p++++    f++ a+ll++ y++++++
  EFC38113.1 377 NlneelvtFDSRDFA--NLSEIVKFFANVKAIFGPHGAAFYNSRFAPRKLAVLEILPSGGFFYQgFWEQASLLEQTYGVYYAQ 457
                 334443333333333..688**************************************9999999**************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 3006.92
//
Query:       EFC38114.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-36  125.9   0.0      3e-36  125.2   0.0    1.3  1  Pyr_redox_2     Pyridine nucleotide-disulphide oxidoreductase
    1.1e-09   38.7   3.8    1.1e-06   29.1   0.1    3.4  4  Pyr_redox       Pyridine nucleotide-disulphide oxidoreductase
    7.7e-08   32.5   0.0     0.0013   18.8   0.0    3.1  3  NAD_binding_9   FAD-NAD(P)-binding
    2.2e-07   30.8   0.0      0.002   17.8   0.0    3.0  3  DAO             FAD dependent oxidoreductase
    0.00096   18.5   9.4        3.4    6.8   0.0    4.1  4  Pyr_redox_3     Pyridine nucleotide-disulphide oxidoreductase
     0.0015   18.7   0.1      0.055   13.7   0.0    2.5  2  NAD_binding_8   NAD(P)-binding Rossmann-like domain
     0.0077   15.3   0.0       0.72    8.8   0.0    2.2  2  Lycopene_cycl   Lycopene cyclase protein
  ------ inclusion threshold ------
      0.022   13.6   0.4       0.12   11.2   0.1    2.1  2  Trp_halogenase  Tryptophan halogenase
      0.024   13.9   0.0        5.6    6.1   0.0    2.8  3  FAD_binding_3   FAD binding domain
      0.036   13.3   0.0       0.54    9.4   0.0    2.2  2  Thi4            Thi4 family
      0.043   13.1   0.1        0.5    9.6   0.0    2.2  2  AlaDh_PNT_C     Alanine dehydrogenase/PNT, C-terminal domain
       0.13   12.5   0.2         20    5.5   0.0    2.6  2  TrkA_N          TrkA-N domain
       0.23   11.9   0.6         28    5.2   0.1    2.6  2  NAD_binding_7   Putative NAD(P)-binding


Domain annotation for each model (and alignments):
>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  125.2   0.0   2.2e-39     3e-36       2     294 .]       6     353 ..       5     353 .. 0.78

  Alignments for each domain:
  == domain 1  score: 125.2 bits;  conditional E-value: 2.2e-39
                  SEEEE--SHHHHHHHHHHHH......HTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHH........HHHHCHHHH.CCCCHCCTCEEEEESCEE CS
                  xxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxx.xxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaq......agakvtlvelegtclnggcllskallgvaedaeias........evvkklnqg.ielllgeevvkidpgkkk 84 
                  +vv++GgG+AGl++  tl        + +++tl+ +++++    ++    +++ +e +++ s        + ++k n   ++++  +++ k+d+++ k
   EFC38114.1   6 RVVIVGGGVAGLSVLSTLTShfvaksQTFNITLI-EKKNFTESSIFTLRYMVNPQEYHHENShvlldeleKTFDKRNGYsVKMISHSQASKLDTEHSK 102
                  8*****************99888877799*****.66666666666655555555555544466777898777777776799999999********** PP

                  EEETEEEC...TCEEEEEESEEEE---EEE-BCTCTTC........TTBEECCSECHHHHHHCCSS-T...SEEEEES-SHHHHHHHHHHHHHT-... CS
                  xxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxx... RF
  Pyr_redox_2  85 vklekkke...gdeekiaydklvlAtGssprdlgipGv.......aenvgklvrtldsaealklkllp...krivvvGgGyiGvElAaalaklgk... 166
                  ++++++++   + ee+i+yd+l+lA G++ ++  i++         ++     + l++  ++ +k +    +++v+vGgG+ G+ lA++l ++++   
   EFC38114.1 103 ITIQQLDGnsiKGEETIEYDYLILANGCRYKTDYIKANiekiesvTPQ-----SRLHEFHQFYDKITSkenDHVVIVGGGALGIQLAGELIDVNQwrg 195
                  ***999989**8999*************77766555443432322222.....3444444444444444557******************99999999 PP

                  .......EEEEEESSSSSS.TTS-HHHHHHHHHHHHHTTEEEEESCEEEEEEETTE........EEEEEETTSCE....................... CS
                  .......xxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxx....................... RF
  Pyr_redox_2 167 .......evtlveardrll.raldkelsaaleealekeGvevklgtsvkeidgnge........klevvledgee....................... 225
                         ++tlv+ r+ l  r+  + + +++ ++l k+Gvev +g+++  + ++ +                                          
   EFC38114.1 196 khglepfKITLVHSRKLLRdRSNSETAHNYIYNHLVKNGVEVFMGKRA--FYKDVSqlvssgeeT---------Nplikkeivlkpnipnaeltseqv 282
                  99*************9999*999**********************998..333333122233340.........244444455555555666666666 PP

                  ...EEESEEEE-S-EEES-HHCSHCCT-EEEETTEEE--TTSBE.SSTTEEE-GGGCTECCSS--HHHHHHHH CS
                  ...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 226 ...idadlvvvavGvrpstelleeklglelderggivvdeflrt.nvpgiyaiGDvaggkggpelaqaAvqqG 294
                      +a++++++ G+ p+te l e + ++ +++g+i+v++f++t n+p+i+ +GDv+ +    +la  Av++G
   EFC38114.1 283 ielPKASMIFWCGGMIPNTEWL-EGSHIARNSQGFIQVNDFYQTvNHPNIFSLGDVT-DLPYEKLAGSAVREG 353
                  88889*****************.********************967***********.666777777777776 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0    0.0018       2.5       1      20 [.       6      25 ..       6      47 .. 0.79
   2 ?   -0.9   0.0       1.8   2.5e+03      22      77 ..      82     104 ..      56     114 .. 0.58
   3 !   29.1   0.1   7.8e-10   1.1e-06       1      62 [.     170     242 ..     170     244 .. 0.87
   4 ?   -2.9   0.0       7.5     1e+04      36      59 ..     411     434 ..     406     437 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0018
                EEEEECSSHHHHHHHHHHHH CS
   Pyr_redox  1 kvvvvGgGyiglElAgalae 20
                +vv+vGgG+ gl + ++l+ 
  EFC38114.1  6 RVVIVGGGVAGLSVLSTLTS 25
                79***********9999965 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.8
                 TSEEEEEESSSSSSTTSSHHHHHHHHHHHHHTTEEEECSEEEEEEEEETTSEEEEE CS
   Pyr_redox  22 gkkVtvversdkllrllDeeaskilqeklekngievllntkveeiegsedgvesvk 77 
                 g                                ++++ ++++ +++++ ++   ++
  EFC38114.1  82 GY------------------------------SVKMISHSQASKLDTEHSK---IT 104
                 33..............................4555555555555544444...22 PP

  == domain 3  score: 29.1 bits;  conditional E-value: 7.8e-10
                 EEEEECSSHHHHHHHHHH.........HHTT...SEEEEEESSSSSS.TTSSHHHHHHHHHHHHHTTEEEECSEE CS
   Pyr_redox   1 kvvvvGgGyiglElAgal.........aelg...kkVtvversdkll.rllDeeaskilqeklekngievllntk 62 
                 +vv+vGgG +g+ lAg+l         +  g    k+t+v+ ++ l+ r   e+a +++ ++l kng+ev ++++
  EFC38114.1 170 HVVIVGGGALGIQLAGELidvnqwrgkH--GlepFKITLVHSRKLLRdRSNSETAHNYIYNHLVKNGVEVFMGKR 242
                 89****************8887665333..34455***********************************98875 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 7.5
                 TTSSHHHHHHHHHHHHHTTEEEEC CS
   Pyr_redox  36 rllDeeaskilqeklekngievll 59 
                  + +++a++i++ek +++ i +l 
  EFC38114.1 411 EVKGQKAADIMTEKGRNRAIGLLR 434
                 556788999999998888777665 PP

>> NAD_binding_9  FAD-NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   9.2e-07    0.0013       1      39 [.       8      47 ..       8      56 .. 0.91
   2 ?    0.7   0.0      0.33   4.5e+02     112     154 ..      80     129 ..      60     131 .. 0.70
   3 !    9.1   0.0    0.0009       1.2       1      62 [.     172     238 ..     172     258 .. 0.81

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 9.2e-07
  NAD_binding_9  1 aivGaGprGlavlerLlara.kkkspleitlfdpsepgag 39
                   +ivG+G++Gl+vl  L ++  +k++ ++itl++++++ + 
     EFC38114.1  8 VIVGGGVAGLSVLSTLTSHFvAKSQTFNITLIEKKNFTES 47
                   7*******************9999**********988655 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.33
  NAD_binding_9 112 pegvtvevh.raevvdleeradgqavlladgas......laadaVvLAlG 154
                    ++g +v+++ ++++ +l++++++ ++ + dg+s      +++d+++LA G
     EFC38114.1  80 RNGYSVKMIsHSQASKLDTEHSKITIQQLDGNSikgeetIEYDYLILANG 129
                    56778888746689999999999888776665433333389999999988 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.0009
  NAD_binding_9   1 aivGaGprGlavlerLlara.....kkkspleitlfdpsepgagrvwrtdqseelllNvpasemslf 62 
                    +ivG+G+ G+ ++ +L++ +     +  +p++itl+  +++ + r  +++ +++   +++ + +++f
     EFC38114.1 172 VIVGGGALGIQLAGELIDVNqwrgkHGLEPFKITLVHSRKLLRDRSNSETAHNYIYNHLVKNGVEVF 238
                    7****************9987777556688******9999998888888876666666666666666 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   1.5e-06     0.002       1      32 [.       6      44 ..       6      52 .. 0.81
   2 ?    1.2   0.0      0.16   2.2e+02     144     203 ..      65     131 ..      52     150 .. 0.67
   3 !    7.6   0.0    0.0018       2.5       1      30 [.     170     211 ..     170     259 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.5e-06
                EEEEECTSHHHHHHHHHHHHT...T.....EEEEESSSST CS
         DAO  1 dvviiGGGiiGlstAyeLarr...g.....Vtllekgdia 32
                +vvi+GGG++Gls+   L+ +   +     +tl+ek+  +
  EFC38114.1  6 RVVIVGGGVAGLSVLSTLTSHfvaKsqtfnITLIEKK-NF 44
                59****************776655256899******9.44 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.16
                 EHHHHHHHHHHHHHHT.T..-EEEESECEEEEEEEETCEEEEE....EECTEEE.EEEEEEEE--GGG CS
         DAO 144 dpakltaalaraaeal.G..veilegtevtgleeedgkvwgve....rttpgen.daadavVnaaGaw 203
                 + + l+  l +++ ++ G  v+++ ++++ +l+ e  k  +++    +  +ge+  ++d++++a+G+ 
  EFC38114.1  65 NSHVLLDELEKTFDKRnGysVKMISHSQASKLDTEHSK-ITIQqldgNSIKGEEtIEYDYLILANGCR 131
                 67777777888875543444899999999999665434.333346553333555457899****9975 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0018
                 EEEEECTSHHHHHHHHHH.......HHTT.....EEEEESSS CS
         DAO   1 dvviiGGGiiGlstAyeL.......arrg.....Vtllekgd 30 
                 +vvi+GGG  G+  A eL        ++g     +tl+ +++
  EFC38114.1 170 HVVIVGGGALGIQLAGELidvnqwrGKHGlepfkITLVHSRK 211
                 79*************999766544333458888888888775 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.026        36       1      35 [.       8      47 ..       8      51 .. 0.67
   2 !    6.8   0.2    0.0026       3.5     216     281 ..      71     144 ..      54     158 .. 0.76
   3 ?    3.2   1.5     0.032        45       1      17 [.     172     188 ..     172     194 .. 0.87
   4 !    6.8   0.0    0.0025       3.4     249     305 .]     279     335 ..     261     335 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.026
  Pyr_redox_3  1 iIiGaGPaGlaaaiel.....kkagledylilEkgnigns 35
                 +I+G+G aGl++  +l      k++  +++ +Ek+n ++s
   EFC38114.1  8 VIVGGGVAGLSVLSTLtshfvAKSQTFNITLIEKKNFTES 47
                 7*********975444111113444457888999988876 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0026
  Pyr_redox_3 216 nrleelvke...ekikvlfnaevkeikekeeeykvktedgkkvev.....kddvvlatGykpdlsflkkslfel 281
                  ++le+  ++    ++k+++++++ +++++++++++++ dg++++      +d  +la G + +++ +k+++ ++
   EFC38114.1  71 DELEKTFDKrngYSVKMISHSQASKLDTEHSKITIQQLDGNSIKGeetieYDYLILANGCRYKTDYIKANIEKI 144
                  45555555555667*********************9777766654444449999***********999754444 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.032
  Pyr_redox_3   1 iIiGaGPaGlaaaielk 17 
                  +I+G+G+ G++ a el 
   EFC38114.1 172 VIVGGGALGIQLAGELI 188
                  7***********98875 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0025
  Pyr_redox_3 249 tedgkkvevkddvvlatGykpdlsflkkslfeldedgrpvlteeteetnvpglflaG 305
                  +e+  ++ + + ++ + G  p+++ l+ s ++++++g++++++  +  n p++f  G
   EFC38114.1 279 SEQVIELPKASMIFWCGGMIPNTEWLEGSHIARNSQGFIQVNDFYQTVNHPNIFSLG 335
                  4444455555555556999***********************************877 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.0     4e-05     0.055       1      29 [.       9      43 ..       9      45 .. 0.85
   2 ?    2.4   0.0      0.13   1.8e+02       1      16 [.     173     188 ..     173     253 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 4e-05
                   EE--SHHHHHHHHHHHCC......TEEEEEE-SSS CS
  NAD_binding_8  1 IvGaGlsGlvaAylLaka......gfdvlllekrd 29
                   IvG+G++Gl+  ++L+ +       f+++l+ek +
     EFC38114.1  9 IVGGGVAGLSVLSTLTSHfvaksqTFNITLIEKKN 43
                   9**************975555556889*****976 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.13
                    EE--SHHHHHHHHHHH CS
  NAD_binding_8   1 IvGaGlsGlvaAylLa 16 
                    IvG+G+ G  +A +L 
     EFC38114.1 173 IVGGGALGIQLAGELI 188
                    9*******99887775 PP

>> Lycopene_cycl  Lycopene cyclase protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0   0.00052      0.72       2      33 ..       7      42 ..       6      95 .. 0.79
   2 ?    4.4   0.1     0.012        16       2      20 ..     171     189 ..     170     207 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00052
  Lycopene_cycl  2 vvviGaGpAglslAarl....teakpglkvvlieas 33
                   vv++G+G Agls+   l    +++ +  +++lie  
     EFC38114.1  7 VVIVGGGVAGLSVLSTLtshfVAKSQTFNITLIEKK 42
                   8**********9877775555788899999999863 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.012
  Lycopene_cycl   2 vvviGaGpAglslAarlte 20 
                    vv++G+G+ g++lA +l++
     EFC38114.1 171 VVIVGGGALGIQLAGELID 189
                    8*************99954 PP

>> Trp_halogenase  Tryptophan halogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   8.5e-05      0.12       1      37 [.       6      45 ..       6      49 .. 0.79
   2 ?    0.0   0.0      0.22     3e+02       2      21 ..     171     190 ..     170     215 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.5e-05
                    EEEEE--SHHHHHHHHHHHHHTTTS...SEEEEEE-SSS- CS
  Trp_halogenase  1 kivivGGGtaGwlaAaalakalkgk...levtlveseeig 37
                    ++vivGGG aG  + ++l  ++  k   +++tl+e++++ 
      EFC38114.1  6 RVVIVGGGVAGLSVLSTLTSHFVAKsqtFNITLIEKKNFT 45
                    69*********998888887664333479******99875 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.22
                     EEEE--SHHHHHHHHHHHHH CS
  Trp_halogenase   2 ivivGGGtaGwlaAaalaka 21 
                     +vivGGG  G   A  l  +
      EFC38114.1 171 VVIVGGGALGIQLAGELIDV 190
                     9*******998877766544 PP

>> FAD_binding_3  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0    0.0041       5.6       3      32 ..       6      41 ..       4      48 .. 0.75
   2 ?   -1.4   0.0      0.78   1.1e+03     134     165 ..      97     131 ..      66     135 .. 0.61
   3 ?    4.6   0.0     0.011        16       3      21 ..     170     188 ..     168     280 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0041
                   EEEEE--SHHHHHHHHHHHHTTHH......EEEEES CS
  FAD_binding_3  3 dVlIVGaGpaGlmlallLseaGvr......vvlvek 32
                    V+IVG+G aGl+  + L+++ v        +l+ek
     EFC38114.1  6 RVVIVGGGVAGLSVLSTLTSHFVAksqtfnITLIEK 41
                   59**********998888877665555555555555 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.78
                    CCCCCCCEEE....ECCTTEEEEEEEEEEEE--GTT CS
  FAD_binding_3 134 deegvtaevr....dketgeeetvrakYlvGaDGgr 165
                    d+e+ + +++    ++ +ge et++ +Yl+ a G r
     EFC38114.1  97 DTEHSKITIQqldgNSIKGE-ETIEYDYLILANGCR 131
                    33333333333332223344.69*******999976 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.011
                    EEEEE--SHHHHHHHHHHH CS
  FAD_binding_3   3 dVlIVGaGpaGlmlallLs 21 
                     V+IVG+G  G+ la +L 
     EFC38114.1 170 HVVIVGGGALGIQLAGELI 188
                    59*************9995 PP

>> Thi4  Thi4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   0.00039      0.54      20      95 ..       7      87 ..       3     119 .. 0.73
   2 ?    1.2   0.0      0.13   1.8e+02      16      34 ..     167     185 ..     154     191 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00039
                EEEE--SHHHHHH.....HHHHHHCTTS-EEEEESSSS--TTT.TTTSTTBSEEEEETTTHHHHHHTT---EEESSEEEESE CS
        Thi4 20 vvivGaGssGLta.....ayylakkpdlkvailersvspGGGa.wlGGqlfsaivvrkpakelLdelgikyedegdyvvvkd 95
                vvivG+G +GL+      ++ +ak+  ++++++e++      +  l  ++  +   +++++ lLdel+  + d+++++ vk 
  EFC38114.1  7 VVIVGGGVAGLSVlstltSHFVAKSQTFNITLIEKKNFTESSIfTLRYMVNPQEYHHENSHVLLDELEKTF-DKRNGYSVKM 87
                9**********9622232677899999*******9865555551456666777778888888999998655.5566666664 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.13
                 TEEEEEEE--SHHHHHHHH CS
        Thi4  16 aesDvvivGaGssGLtaay 34 
                  +  vvivG+G+ G+  a 
  EFC38114.1 167 ENDHVVIVGGGALGIQLAG 185
                 33459********998765 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00036       0.5      29      47 ..       5      23 ..       2      75 .. 0.76
   2 ?    0.6   0.1      0.21   2.9e+02      28      42 ..     168     182 ..     161     190 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00036
                 -EEEEESTSHHHHHHHHHH CS
  AlaDh_PNT_C 29 akvlviGgGvaGlqAiata 47
                  +v+++GgGvaGl+ ++t 
   EFC38114.1  5 PRVVIVGGGVAGLSVLSTL 23
                 58***********988775 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.21
                  --EEEEESTSHHHHH CS
  AlaDh_PNT_C  28 pakvlviGgGvaGlq 42 
                  + +v+++GgG  G+q
   EFC38114.1 168 NDHVVIVGGGALGIQ 182
                  568********9998 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.031        42       1      30 [.       7      42 ..       7      53 .. 0.85
   2 ?    5.5   0.0     0.015        20       1      21 [.     171     192 ..     171     231 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.031
                EEEES-SHHHHHHHHHHHHTT.......EEEEEEESS CS
      TrkA_N  1 iiiiGlGrvGrslaeeLsegg.......kdvvvidkd 30
                ++i+G G  G s++ +L+++        + +++i+k+
  EFC38114.1  7 VVIVGGGVAGLSVLSTLTSHFvaksqtfN-ITLIEKK 42
                79***************996568888855.8888875 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.015
                 EEEES-SHHHHHHHHHHHH.TT CS
      TrkA_N   1 iiiiGlGrvGrslaeeLse.gg 21 
                 ++i+G G +G +la eL + ++
  EFC38114.1 171 VVIVGGGALGIQLAGELIDvNQ 192
                 79***************99777 PP

>> NAD_binding_7  Putative NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.038        53       8      29 ..       5      26 ..       2      94 .. 0.69
   2 ?    5.2   0.1      0.02        28       6      27 ..     167     188 ..     163     192 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.038
  NAD_binding_7  8 kkvlvvGgGevAarkvrkllea 29
                    +v++vGgG  +++ +++l + 
     EFC38114.1  5 PRVVIVGGGVAGLSVLSTLTSH 26
                   589*********9988888753 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.02
  NAD_binding_7   6 kgkkvlvvGgGevAarkvrkll 27 
                    ++ +v++vGgG ++ + +  l+
     EFC38114.1 167 ENDHVVIVGGGALGIQLAGELI 188
                    688*********9987666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       648  (0.0361426); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 2492.93
//
Query:       EFC38115.1  [L=1405]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.5e-20   72.1  70.7    2.7e-05   24.4   7.9    5.5  5  EGF_2            EGF-like domain
    3.7e-09   36.9   0.9    1.1e-08   35.4   0.9    1.8  1  RGS              Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.093   13.1  67.0      0.083   13.2   6.5    6.2  6  EGF              EGF-like domain
        2.6    8.5   6.4         26    5.3   0.4    3.0  2  MPP6             M-phase phosphoprotein 6


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   8.9   1.6e-07    0.0007       6      32 .]       2      27 ..       1      27 [. 0.92
   2 !   24.4   7.9     6e-09   2.7e-05       4      32 .]      39      66 ..      37      66 .. 0.92
   3 !   15.7   6.9   3.2e-06     0.014       4      32 .]      78     105 ..      74     105 .. 0.90
   4 !   20.1   8.6   1.4e-07   0.00062       6      32 .]     119     144 ..     115     144 .. 0.91
   5 !   16.6   6.4   1.7e-06    0.0076       5      32 .]     157     183 ..     153     183 .. 0.92

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 1.6e-07
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                + C+ghG+C  ++ +C C++gy+G +C
  EFC38115.1  2 NVCSGHGSCPVPN-NCTCQPGYYGYQC 27
                57*******8899.8*********999 PP

  == domain 2  score: 24.4 bits;  conditional E-value: 6e-09
       EGF_2  4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32
                +++ C+ hG+C +++ +C+C++gy+G+ C
  EFC38115.1 39 NSNVCSTHGQCLSPN-NCFCEAGYYGPEC 66
                4789********999.8************ PP

  == domain 3  score: 15.7 bits;  conditional E-value: 3.2e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C  hGtC +++ +C+C+ gy+  +C
  EFC38115.1  78 SSNVCFKHGTCLSPN-NCSCQEGYFSFDC 105
                 3789********999.8********9999 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 1.4e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG+C  +  +C C++gy+G tC
  EFC38115.1 119 NVCSSHGSCFVPD-NCTCQPGYYGQTC 144
                 78*******9899.8************ PP

  == domain 5  score: 16.6 bits;  conditional E-value: 1.7e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+Cv+++  C+C  g++ k+C
  EFC38115.1 157 SSVCSGKGQCVSPNY-CSCVEGFTNKDC 183
                 578********9**6.************ PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.4   0.9   2.4e-12   1.1e-08       4     117 ..    1246    1384 ..    1243    1385 .. 0.89

  Alignments for each domain:
  == domain 1  score: 35.4 bits;  conditional E-value: 2.4e-12
                  HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.............. CS
         RGS    4 slledqpgrslFreFlesefseenlsFwlaveefkka...keqeelkkkakeIyneylapsspkelnidkklreelekrleke.............. 83  
                  + le++ g +lF +F+e+efs+enl ++ +++        ++   l+  a++Iy++y++++++ e+ni++k r+   +  ek               
  EFC38115.1 1246 NTLESEEGYELFANFCEKEFSSENLFLFSDIKASTDVvsgENLGGLVFFADRIYQKYIKTGAEMEVNIPSKSRTAFIQLYEKCkkldesncelldln 1342
                  679999*************************999999444555555556*************************999988888899*********** PP

                  .........STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS   84 .........qpsrklfeeaqeevfellekdsypkFlkselylr 117 
                           +  +++fe + ++v   l  d +++F+ ++ y +
  EFC38115.1 1343 slsklgienSMVKDCFELMMRQVVMNL-GDTFSRFVFTPDYVN 1384
                  *******999999**********9999.689****99988865 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   8.3    0.0083        37       5      30 ..       2      24 ..       1      24 [. 0.80
   2 ?    8.4   6.2   0.00059       2.7       3      31 ..      40      64 ..      38      65 .. 0.88
   3 ?    9.6   5.0   0.00024       1.1       3      29 ..      79     101 ..      77     102 .. 0.87
   4 ?   13.2   6.5   1.9e-05     0.083       3      31 ..     117     142 ..     116     143 .. 0.85
   5 ?    6.7   2.8     0.002       8.9       6      31 ..     160     181 ..     154     182 .. 0.89
   6 ?   -3.1   0.4       2.3     1e+04      17      25 ..     850     858 ..     841     859 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0083
                T.STTT-EE.EEETTTEEEEEECTTEES CS
         EGF  5 p.CsngGtC.vdtgrggytCiCpeGytG 30
                + Cs++G C v       +C+C++Gy G
  EFC38115.1  2 NvCSGHGSCpV-----PNNCTCQPGYYG 24
                44*******44.....456*******98 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00059
                STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF  3 pnpCsngGtCvdtgrggytCiCpeGytGk 31
                +n Cs +G C+++     +C+C  Gy G+
  EFC38115.1 40 SNVCSTHGQCLSPN----NCFCEAGYYGP 64
                566*******9999....*********96 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00024
                 STTSTTT-EEEEETTTEEEEEECTTEE CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGyt 29 
                 +n C ++GtC+++     +C C+eGy+
  EFC38115.1  79 SNVCFKHGTCLSPN----NCSCQEGYF 101
                 466*******9999....*******95 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 1.9e-05
                 STT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 +++ Cs +G C+ +     +C+C++Gy G 
  EFC38115.1 117 DTNvCSSHGSCFVPD----NCTCQPGYYGQ 142
                 5556*******7777....*********96 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.002
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs+ G Cv++     +C C eG+t k
  EFC38115.1 160 CSGKGQCVSPN----YCSCVEGFTNK 181
                 99*********....********976 PP

  == domain 6  score: -3.1 bits;  conditional E-value: 2.3
                 TTEEEEEEC CS
         EGF  17 rggytCiCp 25 
                 +++ +C C+
  EFC38115.1 850 SNSIECACS 858
                 58889*997 PP

>> MPP6  M-phase phosphoprotein 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.4    0.0058        26       2      16 ..     776     790 ..     775     793 .. 0.90
   2 ?    4.6   0.9    0.0098        44      75     115 ..    1207    1251 ..    1089    1263 .. 0.56

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0058
        MPP6   2 kLSsrvlnMKFMkra 16 
                  LSs+v + KFMk++
  EFC38115.1 776 TLSSSVTDFKFMKKT 790
                 59***********97 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0098
        MPP6   75 rsFggfnkevee....kkeeeeeeeekekeedvsdeelakrykks 115 
                  ++Fgg+   v      ++++ ++ee+k++ +++  +el + ++++
  EFC38115.1 1207 LVFGGYALIVALvykfRQRRTKKEEQKKQNDEIMNQELYNTLESE 1251
                  566666666662456888888899999999999999998888554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1243  (0.069329); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.96u 0.35s 00:00:01.31 Elapsed: 00:00:00.52
# Mc/sec: 8073.99
//
Query:       EFC38116.1  [L=500]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-23   81.5 132.1    0.00013   22.3   9.8    9.1  9  EGF_2     EGF-like domain
      0.007   16.9   0.0        5.4    7.6   0.0    2.3  2  B_lectin  D-mannose binding lectin


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   6.5   7.3e-06     0.066       6      31 ..      47      71 ..      43      71 .. 0.84
   2 ?   -3.6   0.2       1.7   1.5e+04      27      32 .]     195     200 ..     195     201 .. 0.82
   3 !   18.4  13.9   2.3e-07    0.0021       5      32 .]     211     237 ..     205     237 .. 0.91
   4 !   22.1   9.6   1.6e-08   0.00015       5      32 .]     251     277 ..     246     277 .. 0.91
   5 !   11.2   8.3     4e-05      0.36       6      32 .]     291     317 ..     287     317 .. 0.90
   6 !   15.1   6.3   2.6e-06     0.023       6      32 .]     331     356 ..     328     356 .. 0.92
   7 !   22.3   9.8   1.4e-08   0.00013       6      32 .]     370     395 ..     366     395 .. 0.91
   8 !   14.0  10.6   5.5e-06     0.049       5      32 .]     408     434 ..     400     434 .. 0.90
   9 !   12.9   6.3   1.2e-05      0.11       5      26 ..     447     467 ..     444     469 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 7.3e-06
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGkt 31
                + CgghG C  ++ +C+C ++ +G+t
  EFC38116.1 47 NSCGGHGFCAGSN-NCYCVDSTSGNT 71
                46********666.8***99988875 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.7
       EGF_2  27 yqGktC 32 
                 ++G +C
  EFC38116.1 195 WSGSQC 200
                 888888 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 2.3e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+ghG+C++    C+C sgy+G tC
  EFC38116.1 211 SSACSGHGSCNARD-SCSCYSGYSGSTC 237
                 578********888.6************ PP

  == domain 4  score: 22.1 bits;  conditional E-value: 1.6e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+GtC  ++  C+C++gy+G  C
  EFC38116.1 251 GTVCNGRGTCTGPN-TCSCQTGYSGTFC 277
                 678********888.9***********9 PP

  == domain 5  score: 11.2 bits;  conditional E-value: 4e-05
       EGF_2   6 eiCgghGtCvnqcGqCd.CdsgyqGktC 32 
                 + C+g GtC +++  C+ C++g++G  C
  EFC38116.1 291 NVCSGFGTCSSPN-TCSnCQAGRYGSEC 317
                 68********999.9*77*********9 PP

  == domain 6  score: 15.1 bits;  conditional E-value: 2.6e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+  G+C++++ +C C+  y+G++C
  EFC38116.1 331 NVCSRVGSCDSKN-NCTCPELYFGDNC 356
                 57********999.8************ PP

  == domain 7  score: 22.3 bits;  conditional E-value: 1.4e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ghG+C +++ +C C+ gy+G +C
  EFC38116.1 370 MVCSGHGSCSSPE-NCTCQEGYYGEDC 395
                 57***********.8************ PP

  == domain 8  score: 14.0 bits;  conditional E-value: 5.5e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C g G C ++   C+Cd +++Gk C
  EFC38116.1 408 TNVCTGFGNCTAFD-TCQCDEQHTGKFC 434
                 578********999.9************ PP

  == domain 9  score: 12.9 bits;  conditional E-value: 1.2e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsg 26 
                  +iC+ hG+C +++ +C Cd +
  EFC38116.1 447 PNICSSHGQCHSFN-NCTCDEN 467
                 479*******9999.8***975 PP

>> B_lectin  D-mannose binding lectin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0014        13      11      62 ..      86     139 ..      79     150 .. 0.76
   2 !    7.6   0.0    0.0006       5.4      18      41 ..     161     184 ..     149     194 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0014
    B_lectin  11 Pikdssgv..lkisedgnLvllnesksvvwstssssssakntvaqLldsGnLvl 62 
                  i +s+g   lk + dgnLvl++      w + ++ + ++   ++L+ +G L +
  EFC38116.1  86 SIYSSNGIyqLKQQVDGNLVLYKPGLVAYWASDTNGQGTAPYNLVLSLDGTLEI 139
                 5655565411555669****************8888888888889998998888 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0006
    B_lectin  18 vlkisedgnLvllnesksvvwsts 41 
                 +l +++dgnLvl+ ++k+v w+++
  EFC38116.1 161 RLVMQSDGNLVLYGAQKEVCWTAN 184
                 477899999999999999999983 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (500 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       836  (0.0466284); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 2997.67
//
Query:       EFC38117.1  [L=637]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.082   12.5   0.1       0.16   11.5   0.1    1.4  1  GNAT_acetyltran  GNAT acetyltransferase
       0.13   12.5   0.8        2.4    8.4   0.1    2.4  2  HHV-5_US34A      Herpesvirus US34A protein family
       0.68    9.7   6.4       0.24   11.2   0.6    2.5  2  Mid2             Mid2 like cell wall stress sensor


Domain annotation for each model (and alignments):
>> GNAT_acetyltran  GNAT acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   2.7e-05      0.16     142     206 ..     355     420 ..     340     424 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.7e-05
  GNAT_acetyltran 142 dfveqfesyedfk.kkGlGvvilkngeivsgasSysvyekgieieidTkedyrrkgLAtivaaali 206
                       fv +f++++df+ +   G +       v  a S +v +  + i+i T++d+  kgL ++  a li
       EFC38117.1 355 RFVFNFSQTKDFNdRYFSGLFRGISAVFVVCAYSSLVISWSHVIDISTRKDQGSKGLSKLNKAILI 420
                      57889999****966677998888888888888888999999****************99888887 PP

>> HHV-5_US34A  Herpesvirus US34A protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.1     0.041   2.5e+02      22      46 ..     286     310 ..     274     313 .. 0.87
   2 ?    8.4   0.1    0.0004       2.4       3      34 ..     471     504 ..     469     508 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.041
  HHV-5_US34A  22 rfivyvvlftvavqrvkqerdahlr 46 
                   fiv+ +l+   ++r+k+ r+  +r
   EFC38117.1 286 MFIVWAILLPRLIERIKKFRQMAMR 310
                  69***************99987776 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0004
  HHV-5_US34A   3 kfflklrkrrrp..vvvprfvrfivyvvlftvav 34 
                  k fl lrkr     ++  rf +fi+ v ++++ v
   EFC38117.1 471 KIFLTLRKRDSNagILEYRFTKFILLVSILSIGV 504
                  99*******865226778*********9998877 PP

>> Mid2  Mid2 like cell wall stress sensor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.6     4e-05      0.24      31      70 ..     401     438 ..     378     442 .. 0.73
   2 ?    0.5   0.7     0.083   4.9e+02      52      71 ..     448     467 ..     446     472 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4e-05
        Mid2  31 essnkskssGLskknrniviGcvvGigvPlllvillllyi 70 
                 ++ +++ s+GLsk n+ i+i   +G  v l+l+i  ++y 
  EFC38117.1 401 STRKDQGSKGLSKLNKAILIAFYLG--VILVLIISGIVYA 438
                 33444889************98765..6788888888886 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.083
        Mid2  52 cvvGigvPlllvillllyif 71 
                 +v+G +vPl+l++ ++ ++f
  EFC38117.1 448 IVLGASVPLFLLTFVIGFMF 467
                 699*******9998887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (637 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1142  (0.0636957); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.50
# Mc/sec: 3837.49
//
Query:       EFC38118.1  [L=265]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (265 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       539  (0.030063); expected 358.6 (0.02)
Passed bias filter:                      458  (0.0255452); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1788.48
//
Query:       EFC38119.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.45
# Mc/sec: 4018.19
//
Query:       EFC38120.1  [L=622]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.007   15.8   1.5      0.011   15.1   1.5    1.2  1  DUF4003   Protein of unknown function (DUF4003)


Domain annotation for each model (and alignments):
>> DUF4003  Protein of unknown function (DUF4003)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   1.5   6.4e-07     0.011      50     165 ..     502     617 ..     491     621 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 6.4e-07
     DUF4003  50 fSnfrgnnrlilaallalneedpeeaiqevlkiyekLkeegFkkssylyltAyiilkasekeeydekiqrtkeiykemKkkHpfLtsedDyllaaL..l 146
                  S+f g+ +  ++  l+ ++ d +e+  ++ ++ye Lk++ + ++  l+l   i+lk+ ++ +++ + +  +++ +e+K++   + +  +yll+ L  +
  EFC38120.1 502 LSDFLGTLKPCISVKLKRDD-DTKEFKFKLQEVYEALKNNSLISQISLELNPTILLKSYRNVATKPQFSTLLQVNQELKEHIVTINK-TEYLLVDLlvM 598
                 58899999999999999777.9999999***************************************************98555555.56666655246 PP

     DUF4003 147 AlsskeieellekiEeiYk 165
                 A+ s + e +  ++E++Y+
  EFC38120.1 599 AQASGKRELIQFQTETFYD 617
                 7777777777778888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (622 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       617  (0.0344135); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.45
# Mc/sec: 4137.24
//
Query:       EFC38121.1  [L=1710]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.3e-53  179.7   0.0    8.4e-53  178.7   0.0    1.5  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    7.5e-18   64.7   0.5    8.4e-17   61.3   0.1    2.8  2  PAS_9          PAS domain
    1.4e-11   44.3   0.0    6.8e-11   42.2   0.0    2.2  2  PAS            PAS fold
    8.6e-07   28.8   0.0    0.00019   21.4   0.0    2.6  2  PAS_8          PAS domain
     0.0012   19.1   0.0     0.0022   18.2   0.0    1.4  1  PAS_4          PAS fold


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  178.7   0.0   2.4e-56   8.4e-53       3     182 ..    1487    1672 ..    1485    1673 .. 0.95

  Alignments for each domain:
  == domain 1  score: 178.7 bits;  conditional E-value: 2.4e-56
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp..eekaahaaklaelaLdmlealeevav 94  
                     ae++ ++t +F+d+vgft+lss+  p e+v++Ln+++  fd+l+d+++++k+ktiGday ++ gl+  +++ +h ++++++a+d +  +++++ 
     EFC38121.1 1487 AEKFADITCFFSDMVGFTSLSSKLAPNELVQMLNQIVMGFDDLTDRYHLEKIKTIGDAYFAAGGLHdlNAQSDHPERVLKFAIDTFGVIRSFNS 1580
                     678999************************************************************9999*****************9998887 PP

  Guanylate_cyc   95 es.....keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182 
                     +      +e++++r+Gi+tGpvvagviG+kk+ yd+wG+++n+Asrmes++k+g+iqvs++tye   + +f+++er  +evkGkg  +ty+l+
     EFC38121.1 1581 NFrkgrfEEQVNIRIGINTGPVVAGVIGRKKFAYDLWGDSINTASRMESNSKPGRIQVSRSTYERVYDLGFSFEER-MIEVKGKGMTQTYLLS 1672
                     76445666*****************************************************************998.69***********986 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.29   1.1e+03       3      30 ..     908     937 ..     906     955 .. 0.70
   2 !   61.3   0.1   2.3e-20   8.4e-17       2     103 ..    1343    1447 ..    1342    1448 .. 0.97

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.29
       PAS_9   3 gili.dnpdgrilyaNeaalrllGys.pee 30 
                 g+++ + ++ +i+ya ++++r++  s +e+
  EFC38121.1 908 GFMLmYRNQETITYAYQKFCRVFTDSaKED 937
                 6666466666788*********96442444 PP

  == domain 2  score: 61.3 bits;  conditional E-value: 2.3e-20
       PAS_9    2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.......kerevevvlirkngetfwvlltaspvkdddge 91  
                  dg++++ + g i+ +N+aa r++G + e+v+gk +++l+   p++++++r+a++++++       k ++++v++irkn++tf+++++++    +++ 
  EFC38121.1 1343 DGVILCSHRGDIEIFNPAAQRMFGNQQEDVIGKLLFTLL--CPQHHDEIRKAVDSMKQtvtefdpKGESFDVECIRKNQTTFPAKMNIFVTLFEKKP 1437
                  8999999********************************..**************************************************99**** PP

       PAS_9   92 lvgiivilrDit 103 
                  ++   ++++Dit
  EFC38121.1 1438 IIT--CFIKDIT 1447
                  ***..******9 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.2   0.0   1.9e-14   6.8e-11       2     113 .]    1333    1446 ..    1332    1446 .. 0.93
   2 ?   -1.8   0.0      0.87   3.1e+03      14      31 ..    1566    1583 ..    1562    1584 .. 0.87

  Alignments for each domain:
  == domain 1  score: 42.2 bits;  conditional E-value: 1.9e-14
                  HHHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEEE CS
         PAS    2 dlraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevras 94  
                  ++r+il+++ d++++  ++g+i  +N+aa++++G ++e+v+gk l+ l+ +++++e ++++    ++ +e+  +  sf++    ++++++++ ++  
  EFC38121.1 1333 KVRNILNAAVDGVILCSHRGDIEIFNPAAQRMFGNQQEDVIGKLLFTLLCPQHHDEIRKAVDSMKQTVTEFDPKGESFDVecirKNQTTFPAKMNIF 1429
                  6899************************************************99999999999999999999999999999999************9 PP

                  EEEETTEEEEEEEEEEEES CS
         PAS   95 pvrdaggeilgflgvlrdi 113 
                   ++++++    + ++++di
  EFC38121.1 1430 VTLFEKKP--IITCFIKDI 1446
                  99999998..699999997 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.87
                  EEEEETTSBEEEECHHHH CS
         PAS   14 ifvvDedgrilyvNaaae 31  
                   f++D  g+i  +N++++
  EFC38121.1 1566 KFAIDTFGVIRSFNSNFR 1583
                  69************9987 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.0    0.0089        32       5      34 ..     899     930 ..     898     949 .. 0.78
   2 !   21.4   0.0   5.2e-08   0.00019       2      57 ..    1333    1390 ..    1332    1403 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0089
       PAS_8   5 alfesspd.giavvd.lgdrivdvNqaalell 34 
                 +l++s++  g ++ + ++++i+++ q++++ +
  EFC38121.1 899 QLMNSLNSyGFMLMYrNQETITYAYQKFCRVF 930
                 678888888***99854448**********99 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 5.2e-08
       PAS_8    2 rlralfesspdgiavvd.lgdrivdvNqaalellGys..adlkgellg.qllpvlrplle 57  
                  + r++++++ dg++++  +gd i   N+aa++++G +  +d++g+ll   l p+++++++
  EFC38121.1 1333 KVRNILNAAVDGVILCShRGD-IEIFNPAAQRMFG-NqqEDVIGKLLFtLLCPQHHDEIR 1390
                  6799**********9878***.*************.768888888886677777777776 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.0   6.1e-07    0.0022       1      62 [.    1338    1395 ..    1338    1409 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.1e-07
       PAS_4    1 ldslpdalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvleg 62  
                  l++  d+++ +++ g ++  N+aa+++fg ++e+++Gk l+ ll +++ ++++ a++    +
  EFC38121.1 1338 LNAAVDGVILCSHRGDIEIFNPAAQRMFGNQQEDVIGKLLFTLLCPQHHDEIRKAVD----S 1395
                  57889************************************9877656655555554....4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1710 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1453  (0.0810419); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.12u 0.30s 00:00:01.42 Elapsed: 00:00:00.53
# Mc/sec: 9786.39
//
Query:       EFC38122.1  [L=1668]
Description: hypothetical protein NAEGRDRAFT_81714 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      8e-52  175.5   0.1    1.9e-51  174.3   0.1    1.7  1  Rap_GAP   Rap/ran-GAP
  ------ inclusion threshold ------
      0.019   15.2   0.2      0.095   13.0   0.2    2.2  1  DUF1722   Protein of unknown function (DUF1722)


Domain annotation for each model (and alignments):
>> Rap_GAP  Rap/ran-GAP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  174.3   0.1   2.1e-55   1.9e-51       1     178 [.    1343    1520 ..    1343    1528 .. 0.91

  Alignments for each domain:
  == domain 1  score: 174.3 bits;  conditional E-value: 2.1e-55
     Rap_GAP    1 ilsNeev..SkrfeeFlelLGekvelkgfkgYsggLdtkknttGehsvytkdrnleimFhVstllptkesdkqqlerkrhigndivvIvFnesgeke 95  
                  il+N+e+  S+ ++eF+++LG+  +++++ g+ ggLd +  ttG++++y+++ ++e++Fh  t +ptk +d+qq+++krh+gnd+v+Iv++e++ ++
  EFC38122.1 1343 ILKNDETsgSRIYKEFVQSLGWDADMRTHGGFMGGLDENL-TTGNTAPYYSNATTEVIFHDVTRMPTKVNDSQQIQKKRHVGNDFVHIVWSEHD-RD 1437
                  7899988889****************************95.6**************************************************87.99 PP

     Rap_GAP   96 fdpsliksqfnhvfivvqplekekskeelyrvsvvskksvppfgPllpeekivskkslaelvrflltkainaeraal....k.assfr 178 
                  ++p +i+sqfn+v+i v+p  ++++++ l+rv++++k++vp fgPll +++iv+kk+l  lvr++   aina++a++    +  ++f 
  EFC38122.1 1438 YKPWTIPSQFNFVHICVYP-YQRHKETYLFRVRIYTKPEVPLFGPLL-DGMIVDKKNLGPLVRMT---AINANKAVRykqkQyRKPFP 1520
                  ******************5.56799*********************5.*****************...*********64442244444 PP

>> DUF1722  Protein of unknown function (DUF1722)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   1.1e-05     0.095      61     106 ..     508     553 ..     500     557 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.1e-05
     DUF1722  61 yfkkklsaeekqelleliekYregkvplsvpltlLkhyarkydney 106
                  +kkk+++e+kq++ + +++Y  + ++++++l+l++++++ ++ne 
  EFC38122.1 508 VVKKKAKTEKKQHIFQGMDTYMSKSISIDTVLHLFHKFLNMFGNEN 553
                 689*************************************999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1668 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1514  (0.0844442); expected 358.6 (0.02)
Passed bias filter:                      629  (0.0350828); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.15u 0.37s 00:00:01.52 Elapsed: 00:00:00.56
# Mc/sec: 9009.42
//
Query:       EFC38123.1  [L=626]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.3e-45  153.2   2.8    6.1e-40  137.2   0.4    2.3  2  Pkinase        Protein kinase domain
    4.8e-25   88.3   0.9    1.2e-22   80.4   0.1    2.3  2  Pkinase_Tyr    Protein tyrosine kinase
    5.2e-05   22.3   0.3    5.2e-05   22.3   0.3    2.9  3  Haspin_kinase  Haspin like kinase domain
     0.0001   21.8   0.0    0.00021   20.7   0.0    1.5  1  Kinase-like    Kinase-like
  ------ inclusion threshold ------
      0.032   14.2   0.5       0.05   13.5   0.5    1.3  1  APH            Phosphotransferase enzyme family
        0.1   12.6   0.5       0.24   11.3   0.5    1.6  1  Peptidase_M16  Insulinase (Peptidase family M16)
       0.19   11.3   4.0      0.066   12.8   0.4    2.0  2  RIO1           RIO1 family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.1   9.2e-07    0.0024       2      42 ..     387     427 ..     386     435 .. 0.83
   2 !  137.2   0.4   2.4e-43   6.1e-40      63     264 .]     427     615 ..     425     615 .. 0.92

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 9.2e-07
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke 42 
                 e  + l +G++G+Vyk+++k tgk vAvK+++ e ++k   
  EFC38123.1 387 ELYRILSKGTYGTVYKGLDKVTGKNVAVKELDLEMMDKIGA 427
                 56678899************************998887655 PP

  == domain 2  score: 137.2 bits;  conditional E-value: 2.4e-43
                 EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTS CS
     Pkinase  63 lyevfeekdelylvleyveggeladllerkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvg 159
                  +e+ ++++ +y+v+e++e+g l++ le++ + +e+++++++ q++ +++++H   +i+HrDl  +N+ +d ++++Ki+DFGl+ ++e+++k  + fvg
  EFC38123.1 427 AIEFAQRETFVYIVTEFCENGALENPLEEHEQHNEDDVQRYFVQMVMAIDHMHnVLSILHRDLTLSNVCLDADRNVKIVDFGLSDKFEKGKKyHRLFVG 525
                 5789999**********************************************6678***********************************666799* PP

                 CGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHH CS
     Pkinase 160 tseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeel 258
                    Y+ PE+l ++ y +++D+++lGv+ly+lltg  pf+  + kek+e++             +   l+e++ ise+ k +++ ll+++  +R+t e++
  EFC38123.1 526 NGAYCCPELLLKKCYAEEIDIYALGVVLYKLLTGFLPFK--TAKEKFEMN-------------YYIPLEEEEGISEKTKYVIEHLLEVNSANRWTLEDV 609
                 ***************************************..333322222.............344788999*************************** PP

                 HTSGGG CS
     Pkinase 259 lqhpyl 264
                 +q++++
  EFC38123.1 610 MQSDWF 615
                 *****8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.1    0.0014       3.6       2      41 ..     387     422 ..     386     427 .. 0.85
   2 !   80.4   0.1   4.9e-26   1.2e-22      72     255 ..     433     609 ..     419     612 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0014
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSS CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeat 41 
                  el + l +G++G+V++g  k     +  +VavK l+ e++
   EFC38123.1 387 ELYRILSKGTYGTVYKGLDK----VTGKNVAVKELDLEMM 422
                  67889************999....88899****9976655 PP

  == domain 2  score: 80.4 bits;  conditional E-value: 4.9e-26
                  SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSG CS
  Pkinase_Tyr  72 keepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklp 168
                  +e  ++ivte++++G L++ L+++  e+ + +d+ ++ +q+  +++++++  +++Hrdl+  Nv l+ ++ vki DfGL+++ ek ++y++      +
   EFC38123.1 433 RETFVYIVTEFCENGALENPLEEH--EQHNEDDVQRYFVQMVMAIDHMHNVlSILHRDLTLSNVCLDADRNVKIVDFGLSDKFEKGKKYHR--LFVGN 526
                  44459******************9..88999******************973699****************************88888864..45667 PP

                  GGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHH CS
  Pkinase_Tyr 169 vkWmapEslkekkftsksDvWsfGvllwEiftlgespypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfsel 255
                    ++ pE l +k + ++ D+++ Gv+l+ ++t g  p+++ k++  +++      le+ e ++e+ + ++++ +e + ++R t++++
   EFC38123.1 527 GAYCCPELLLKKCYAEEIDIYALGVVLYKLLT-GFLPFKTAKEKFEMNY---YIPLEEEEGISEKTKYVIEHLLEVNSANRWTLEDV 609
                  799*****************************.*****99855433333...23456666666666666666666666666666665 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   1.2      0.75   1.9e+03      23      73 ..       4      53 ..       2      67 .. 0.81
   2 ?    2.6   0.0     0.021        54      72     139 ..     357     425 ..     318     432 .. 0.80
   3 !   22.3   0.3     2e-08   5.2e-05     181     254 ..     434     510 ..     427     522 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.75
  Haspin_kinase 23 tshssLqkfsssssessssnkislPvkdqvsrdkikkklrnsesllslnsq 73
                   +s ssL + s+  ++ +++n+i  P+++  s d++   ++++++++  +s+
     EFC38123.1  4 SSSSSLGR-SEETKTPTKENSIFRPTPKLTSIDFTCLYPSSASKVAAAVSR 53
                   56688888.566677788999*******99999999999999888877775 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.021
  Haspin_kinase  72 sqeevkdfdevilsqilelckikkilneadlasllndseklssevyqtke..kdkevvlKviplevledv 139
                    s  ++k+ ++++ ++ l+  +i +i+ne+ +      s++ ++ vy+  +  + k+v++K + le+++ +
     EFC38123.1 357 SPPTPKSSNHIVDEKNLKPADIYMIINEQFELYR-ILSKGTYGTVYKGLDkvTGKNVAVKELDLEMMDKI 425
                    4445578888899999999***888877744333.3488899*****988678999*****999998877 PP

  == domain 3  score: 22.3 bits;  conditional E-value: 2e-08
  Haspin_kinase 181 eqqlflvlllkdkG...tdLeevklkswkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlkls 254
                    e+ +++v ++ ++G   ++Lee + ++ +++++ f q+v  +    + +   HRdL+l n+ +d+  nv ++d+ ls
     EFC38123.1 434 ETFVYIVTEFCENGaleNPLEEHEQHNEDDVQRYFVQMVMAIDHMHNVLSILHRDLTLSNVCLDADRNVKIVDFGLS 510
                    555677777888885556********************************************************987 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0   8.2e-08   0.00021     148     288 .]     467     603 ..     446     603 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 8.2e-08
  Kinase-like 148 llTlqlirlaanLqa.kglvhgkftvdnllldekgglmlggft..aLvragtkvvl.sevekgfaPpEllgsrggytrknktkmthkldaWqlGlviy 241
                  +  +q++  + ++++ + ++h ++t  n++ld +  +++ +f+    + +g+k+      + ++  pEll ++          ++ ++d ++lG+v y
   EFC38123.1 467 YF-VQMVMAIDHMHNvLSILHRDLTLSNVCLDADRNVKIVDFGlsDKFEKGKKYHRlFVGNGAYCCPELLLKK---------CYAEEIDIYALGVVLY 554
                  33.577888888875379**********************99632345556665541555589*******993.........35669*********** PP

  Kinase-like 242 riwclklPltlateeakeew..kfklckkipekvkaLlkkfLqlsqedR 288
                   +    lP+  a+e+++ ++   ++  + i+ek k  ++++L++++ +R
   EFC38123.1 555 KLLTGFLPFKTAKEKFEMNYyiPLEEEEGISEKTKYVIEHLLEVNSANR 603
                  *******************9555666679***************99988 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.5     2e-05      0.05     164     196 ..     480     510 ..     442     512 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2e-05
                 S-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 164 lptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                    ++lH+Dl + N+ +d+d +    ++Df+++
  EFC38123.1 480 NVLSILHRDLTLSNVCLDADRNVK--IVDFGLS 510
                 56789*************777777..****986 PP

>> Peptidase_M16  Insulinase (Peptidase family M16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.5   9.5e-05      0.24      61     121 ..     216     277 ..     201     294 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 9.5e-05
                    TCEEEEEEESSEEEEEEEEEGGGHHHHHHHHHHHHHSBTTSHHHHHHHHH.HHHHHHHHHCC CS
  Peptidase_M16  61 GgslnAttsrentvYyvevlskdlekaldvladvfkaplleesevererk.vvekeveavda 121
                      +++++ +++n +Yy + l +++++ ++ l++ f+  ++ee +  ++ +  + +  + +d+
     EFC38123.1 216 QYQMDCFVCYDNFTYYNSELWSKFQNTMEYLQQQFNFRTFEEFTCRTQFEdHIVETTNIMDS 277
                    55789************************************988887665445555555555 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.2       1.5   3.8e+03      23      41 ..     237     255 ..     233     266 .. 0.82
   2 ?   12.8   0.4   2.6e-05     0.066      83     150 ..     439     508 ..     431     519 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.5
                 -SS-HHHHCTTTSTTSTCG CS
        RIO1  23 teFkkrkkyvsgekrfkdr 41 
                 ++F++  +y +++++f++ 
  EFC38123.1 237 SKFQNTMEYLQQQFNFRTF 255
                 68999999****9999864 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 2.6e-05
                 EEEE--EETTEEGGBHHHCG.-.HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETT.EEEE--GT CS
        RIO1  83 lvmefigedgvaapklkdve.e.eeeaeelyeevleemrklykeaglvHaDLSeyNvlvded.kvviIDvs 150
                 +v ef++ +g     l++ e + e++ ++++ +++ ++  + +   + H DL   Nv +d d +v i+D++
  EFC38123.1 439 IVTEFCE-NGALENPLEEHEqHnEDDVQRYFVQMVMAIDHMHNVLSILHRDLTLSNVCLDADrNVKIVDFG 508
                 7889999.6666666666664459999***********************************99*****96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (626 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       971  (0.0541581); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.70u 0.36s 00:00:01.06 Elapsed: 00:00:00.51
# Mc/sec: 3666.55
//
Query:       EFC38124.1  [L=312]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-42  145.2   0.6    2.9e-42  144.5   0.6    1.3  1  NAD_binding_2   NAD binding domain of 6-phosphogluconate dehy
      1e-33  116.2   0.1    1.6e-33  115.5   0.1    1.3  1  NAD_binding_11  NAD-binding of NADP-dependent 3-hydroxyisobut
    1.1e-07   32.3   0.1    2.5e-07   31.2   0.1    1.6  1  F420_oxidored   NADP oxidoreductase coenzyme F420-dependent
    1.2e-06   28.7   0.0    2.3e-06   27.7   0.0    1.5  1  Shikimate_DH    Shikimate / quinate 5-dehydrogenase
    2.2e-05   23.9   0.0      4e-05   23.0   0.0    1.3  1  2-Hacid_dh_C    D-isomer specific 2-hydroxyacid dehydrogenase
     0.0052   16.1   0.3     0.0097   15.2   0.3    1.4  1  AlaDh_PNT_C     Alanine dehydrogenase/PNT, C-terminal domain
     0.0091   15.9   0.1      0.015   15.2   0.1    1.3  1  3HCDH_N         3-hydroxyacyl-CoA dehydrogenase, NAD binding 


Domain annotation for each model (and alignments):
>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  144.5   0.6   1.1e-45   2.9e-42       1     158 []      15     176 ..      15     176 .. 0.97

  Alignments for each domain:
  == domain 1  score: 144.5 bits;  conditional E-value: 1.1e-45
                    EEEEE--SHHHHHHHHHHHHTT-E.EEEE-SSHHHHHHHHHTTEEE-SSHHHHHHHCSEEEE-SSSHHHHHHHHHS....HCCC--TT-EEEE-S- CS
  NAD_binding_2   1 kigfiGlGvMGsnmalnllkagyk.vavynrtkekveelvaegakaaesieelvasldvvitmvkagkavdevieg....llealkkgdilidgst 91 
                    ++gf+G+GvMG+++a+nl+++gyk ++vy rtk+k++ l++ gak+a+s++e+ a+ dvvi +v   ++v++vi +    +l+ +k+g +++d++t
     EFC38124.1  15 RVGFLGVGVMGKSIATNLINKGYKnMTVYTRTKSKADPLIELGAKLAASPKEVGANSDVVISIVGYPSDVRSVILDeengVLSGMKEGGVIVDMTT 110
                    58********************96589***********************************************9999****************** PP

                    --HHHHHHHHHHHHHTT-EEEEEEEESHHHHHHHT-EEEEEEE-HHHHHHHHHHHHHHEEEEEEE-E CS
  NAD_binding_2  92 sspedtrelakelkekglkfldaPVSGGeegAekGtLsimvGGseeafervkpvleaigakvthviG 158
                    s+p+ + e+++++kekg+  ldaP SGG+ gA+++tL+i+vGG+e ++ +v+p++e+ig+++  ++G
     EFC38124.1 111 SQPSLAVEIYNKAKEKGVYSLDAPCSGGDIGARNATLTIFVGGDEPVLGAVTPIFESIGKTIN-FMG 176
                    ************************************************************998.445 PP

>> NAD_binding_11  NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.5   0.1   6.2e-37   1.6e-33       1     119 [.     179     296 ..     179     299 .. 0.98

  Alignments for each domain:
  == domain 1  score: 115.5 bits;  conditional E-value: 6.2e-37
  NAD_binding_11   1 GaGqavKlvnnlllainlaaasEalvlaekaGldpekvlevinassgrsnalenklpqrvlsrdfdpgFaldlmlKDlglalelareagaplpll 95 
                     G+Gq++K++n++++a++++ ++E+l++a+kaGld+++ l+++++++++s++l+++ p r+l+rdf+pgF +++++KD++++l++a+++++ lp l
      EFC38124.1 179 GKGQHAKMANQVIIATSMIGVCEGLLYAHKAGLDVHQTLKAVSGGAANSFSLQSYGP-RILKRDFEPGFYVEHFIKDMEIVLSEANKMQLVLPGL 272
                     99*******************************************************.8************************************ PP

  NAD_binding_11  96 alaeqlyaaaaaegggdaDhsaiv 119
                     +la+ ly +++++gg+++  +a++
      EFC38124.1 273 NLAKMLYDSLRNNGGAKNGTQALI 296
                     *****************9999887 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2   0.1   9.8e-11   2.5e-07       1      78 [.      15      88 ..      15     110 .. 0.77

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 9.8e-11
                   EEEEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHHHHHC-EEECECHHHHHHH-SEEEE-S-.HHHHHHHH CS
  F420_oxidored  1 kigiiGaGnmgealasgllaagaqpheivvansrnpekaeelaeelgvkvtavdneeaaeeadvvvlavk.pedveevl 78
                   ++g++G G mg+++a +l+++g   ++++ + +r+++ka+ l e lg+k+ a + +e+ +++dvv+  v  p+dv +v+
     EFC38124.1 15 RVGFLGVGVMGKSIATNLINKG--YKNMT-VYTRTKSKADPLIE-LGAKLAA-SPKEVGANSDVVISIVGyPSDVRSVI 88
                   69********************..44455.669********965.5789988.8999********97774255666665 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.0   8.8e-10   2.3e-06      12      84 ..      13      79 ..       4     124 .. 0.81

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 8.8e-10
                  T-EEEEES-SHHHHHHHHHHHCCT-CEEEEEESSHHHHHHHHHHHT.ET-EEEEGCGHHHHHHT-SEEEE-SS CS
  Shikimate_DH 12 ekkvlliGaGemaelvakhLlakgvkkvvvaNRtlerakelaeelkgeeiealkleelkellaeadvvisata 84
                  + +v  +G G m++ +a++L++kg+k+++v  Rt ++a+ l e   ++        + ke+ a++dvvis ++
    EFC38124.1 13 STRVGFLGVGVMGKSIATNLINKGYKNMTVYTRTKSKADPLIELG-AK-----LAASPKEVGANSDVVISIVG 79
                  578999**********************************97544.33.....44455566678888887665 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   1.6e-08     4e-05      37     126 ..      14     108 ..       4     114 .. 0.89

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 1.6e-08
                   SEEEEES-SHHHHHHHHHHHHTT-.EEEEESSSHHHHHCHHHHTCEEC.SHHHHHHH-SEEEE-S--STTTTTSBSHHH...HHCSTTTEEEEES CS
  2-Hacid_dh_C  37 ktvGiiGlGrIGqavakrlkafgm.kviaydrskkkeeeeeelgvelv.sleellaesDivslhlpltpetrhlinaee...lakmkkgailiNt 126
                    +vG +G+G +G+++a  l   g  ++++y r+k+k +   elg++l+ s +e+ a+sD+v+  + +  + r +i +ee   l+ mk+g +++ +
    EFC38124.1  14 TRVGFLGVGVMGKSIATNLINKGYkNMTVYTRTKSKADPLIELGAKLAaSPKEVGANSDVVISIVGYPSDVRSVILDEEngvLSGMKEGGVIVDM 108
                   68*****************9999978999****9999999999998777*******************99999996664455999***9999975 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.3   3.8e-06    0.0097      31     131 ..      16     112 ..      10     129 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 3.8e-06
                  EEEESTSHHHHHHHHHHHHTT-.EEEEEESSHHHHHHHHHTTTCECEEHCHHHHHHHHHHHH-SEEEE---BTTSS---SC-HH..HHHTS-TTEEEE CS
  AlaDh_PNT_C  31 vlviGgGvaGlqAiatakglga.kVtvlDvrparleqleslgakfvevlksqeellaeavkeadvvigtvlipGkkaPkLvtee..mvksMkpgsViv 125
                  v  +G+Gv G + + +  + g  + tv+   ++++  l +lgak    l   +++ +e  +++dvvi+ v  p     ++++ee  +++ Mk+g Viv
   EFC38124.1  16 VGFLGVGVMGKSIATNLINKGYkNMTVYTRTKSKADPLIELGAK----L---AASPKEVGANSDVVISIVGYPSDVRSVILDEEngVLSGMKEGGVIV 106
                  55677777777655555555541445555555555556666666....3...34444556789****************999874479********** PP

                  ETTGGG CS
  AlaDh_PNT_C 126 DvAidq 131
                  D+ ++q
   EFC38124.1 107 DMTTSQ 112
                  **9887 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.1   5.7e-06     0.015       2      36 ..      16      50 ..      15      87 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 5.7e-06
                EEEE--SCCHHHHHHHHHHTT-EEEEE-S-HHHHH CS
     3HCDH_N  2 vaviGaGtmGagiaavfasagleVvlvdiseeale 36
                v+ +G G+mG++ia+ ++++g++   v +++++ +
  EFC38124.1 16 VGFLGVGVMGKSIATNLINKGYKNMTVYTRTKSKA 50
                899*******************8666555544443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (312 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       437  (0.0243739); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.33s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1800.28
//
Query:       EFC38125.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.1e-07   31.0  10.0    6.2e-07   29.4   7.5    2.4  2  Folate_rec  Folate receptor family


Domain annotation for each model (and alignments):
>> Folate_rec  Folate receptor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4   7.5   3.5e-11   6.2e-07      19     108 ..      48     147 ..      38     153 .. 0.73
   2 ?    0.2   0.0     0.033   5.9e+02     140     170 ..     158     188 ..     151     190 .. 0.64

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 3.5e-11
                 GGGGGGGTTSBSSBHHHHHHTTSSSXTTTSS.TTTT.........SCXXHHHHHHHHHHHHHHHHXSCCGGGEEE..TCCEEEXSEEEXHHHHHHHHHH CS
  Folate_rec  19 leeCspykensCCtsetseelssdesilanfrwerC.........gelsqeCekfleqlecfyecsphlglwikp..erkerilkvpLCeelCdawfea 106
                 l  C++y+ nsCCt + s++++++ +  +  +  +           +    C + l+q  c y csp + ++i++  +   + + + LC+++Cd+++++
  EFC38125.1  48 LATCQWYNPNSCCTVDSSKKIKQGWESQSGRNSGSSnvtipqflvEAFAGGCLDELHQYIC-YLCSPGQTNFIEEkiQILGQKSILYLCSSFCDRLYSK 145
                 445***********9999998876554332222222223333354778889**********.66********999443344445556************ PP

                 TT CS
  Folate_rec 107 Ck 108
                 C 
  EFC38125.1 146 CA 147
                 *5 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.033
                 HHHSSSHHHHHHHTTTTSEEEXSSXTTSSSS CS
  Folate_rec 140 kqvfangtdlcesvlgesfkvaekskgskrC 170
                  + +a+g+d+ces l++  +  + +    +C
  EFC38125.1 158 ITSYASGKDFCESGLNDPSNQLQIKVRDANC 188
                 566899*****99887744444333344555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.53
# Mc/sec: 1217.14
//
Query:       EFC38126.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       578  (0.0322383); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 755.68
//
Query:       EFC38127.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-88  297.9   0.0    1.2e-88  297.6   0.0    1.0  1  Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase famil
    0.00087   19.2   0.5     0.0022   17.9   0.5    1.7  1  DUF4021       Protein of unknown function (DUF4021)


Domain annotation for each model (and alignments):
>> Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  297.6   0.0   1.4e-92   1.2e-88       1     342 []      11     359 ..      11     359 .. 0.88

  Alignments for each domain:
  == domain 1  score: 297.6 bits;  conditional E-value: 1.4e-92
                   CCCS-EEET........TEEESSSEEE----S-TTTTTCS.HHHHHHHHHHHHHHTT-SEEEEEEEESSCCC-SCTTSEE-SSGGGHHHHHHHHHHH CS
  Oxidored_FMN   1 kLFkPikig........nmtLknRivmapmtrlraldkgnvledlaaeyysqraeipvtliiteaafvnpksggfdnapgiwdeeqieewrklteav 89 
                   kLF+P+++g          tL +Rivmap+tr ra d +   +++a+ yysqra  p++lii+ea+ ++p+++g++ +pg++++ q+++w+k+t+av
    EFC38127.1  11 KLFTPLTLGtdkipatqRITLSHRIVMAPLTRCRAVDGDCEQTEHAITYYSQRAT-PGGLIIAEASQITPQGQGYPCSPGCYSQAQVKAWKKVTDAV 106
                   689999998333333323589******************9999***********9.***************************************** PP

                   HHTT-EEEEEEE--GGGS..SCSTCEC..SS.ESSSSSTTT-.S...CS-EE--HHHHHHHHHHHHHHHHHHHHTT-SEEEEEE-CTSHHHHHH-TT CS
  Oxidored_FMN  90 hengskvvvqlwhlGreakseyladqevdspsdpvaldaqeeesaeevykkeltkeeikqliqefveAAkraieAgfDgVeihganGYLlnqFlspk 186
                   h++g+ +++qlwh Gr+  ++++    v    d +  + q +e++ +  +k+l+ eeik ++ ++++AA +a+ AgfDgVe h+anGYL++qFl+++
    EFC38127.1 107 HQKGGVIFLQLWHVGRQRYADNVSSSAVPIQNDTS-TNLQTREQQLPTTPKALSIEEIKVIMGQYKQAASNAKLAGFDGVELHAANGYLVDQFLQNG 202
                   ******************99999998833333332.33333366777779*********************************************** PP

                   T----STTSSSHHHHHHHHHHHHHHHHHHH-SSS..EEEEEECE--STTS--HHHHHHHHHHHCHCCEEEEEEETT-SSSSSTTS-TTTTHHHCCTT CS
  Oxidored_FMN 187 snkrtDeygGslenRarFllevvdaVkeavgeer..vgyRlSpedvvekgldfaetaqkivllkelekrlkdgkklalvhaaeprkrgagsvrteqe 281
                    nkrtDeygGs+enR+rF++e + a  e   +e   vg+RlSp++ + + +d+       + l e +++++d   la++h++epr  g  ++   q 
    EFC38127.1 203 VNKRTDEYGGSIENRLRFMREAISACIEGFDNESdrVGIRLSPSGCFLEISDSDP-----KPLFEAAVKALDEYDLAYIHLVEPRISGGANSDDGQA 294
                   *****************************9999888***********98877644.....578888899999999**********987666665543 PP

                   .HHH....HHHCCCHSSEEEE-SS--SHHHHHHHHHTTS-SEEEESTHHHH-TTHHHHHHCCTCGG CS
  Oxidored_FMN 282 .knt....efvkevwkkplitvgriadeekaaeivaegeadLvamgRefladpdlveklkkglpln 342
                    ++     + +k +   p+i +g+++ ++ a+ + +eg  d++a+gR+f+++pdlve++++g pln
    EFC38127.1 295 eSKPvvvtKELKPLTRSPIISAGGFTPAT-AKSTTEEGATDMIAFGRHFISNPDLVERIRNGHPLN 359
                   22223455999******************.9999***************************99886 PP

>> DUF4021  Protein of unknown function (DUF4021)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.5   2.5e-07    0.0022       2      24 ..     127     149 ..     126     152 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.5e-07
     DUF4021   2 EevsesktlksNdstanLqivEQ 24 
                 ++vs s+ +++Nd  +nLq  EQ
  EFC38127.1 127 DNVSSSAVPIQNDTSTNLQTREQ 149
                 59********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       407  (0.0227007); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2457.61
//
Query:       EFC38128.1  [L=1223]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.2e-55  187.0   2.0      6e-55  186.4   2.0    1.3  1  Pkinase         Protein kinase domain
    3.6e-37  128.1   0.1    1.2e-36  126.4   0.3    1.7  2  Pkinase_Tyr     Protein tyrosine kinase
    7.2e-17   60.5   0.1    0.00025   20.9   0.0    6.2  5  NHL             NHL repeat
    4.3e-06   25.8   0.0    8.4e-06   24.8   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase
     0.0005   19.7   1.7       0.15   11.6   1.3    3.6  3  SGL             SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
       0.01   15.4   0.1      0.025   14.1   0.1    1.6  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL
       0.11   11.8   0.1       0.19   11.1   0.1    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  186.4   2.0   2.4e-58     6e-55       1     264 []     964    1222 ..     964    1222 .. 0.88

  Alignments for each domain:
  == domain 1  score: 186.4 bits;  conditional E-value: 2.4e-58
                  EEEEEEEEEESSEEEEEEEETTT.TEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEE.EEEE--TTEBHHHHHHHHSS- CS
     Pkinase    1 yekleklGeGsfGkVykaveket.gkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely.lvleyveggeladllerkgsl 95  
                  y+++e++G+G+fG+Vyka +++  ++i AvK+ik e+ ++ +  ++++E + l ++khpni+++ ++f ++d+l+ + ++y e g+l+++l+r    
  EFC38128.1  964 YTNIERIGQGAFGSVYKANDSKAgNRIKAVKVIKFESFSDLN--TIMKEASQLSHIKHPNILKVNDYFITQDSLLcIDMDYYESGDLNQFLKR--EC 1056
                  78899*************9977626788********999977..5***********************9988876488*************85..89 PP

                  -HHHHHHHHHHHHHHHHHHHHT.TEE-SS-SGGGEEEE..TTTE...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHH CS
     Pkinase   96 seeeakkiakqilegleylHsk.giiHrDlKpeNiLid..ekge...lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvi 186 
                  se+ +k+i+kq +egl+y+Hs+ +iiHrD+Kp+Ni+++  ++ +   + i+DFGlak+ ++ +  +s+vgt+ +++PE+  +++ys ++D++slGv 
  EFC38128.1 1057 SENIIKQILKQSCEGLNYIHSQlSIIHRDIKPSNIFVKylKN-DnieIVIADFGLAKKHQEMK-GQSYVGTPLFMSPEIALGSSYSFNTDIFSLGVS 1151
                  ********************6526**************6333.358899*********99988.9******************************** PP

                  HHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase  187 lyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264 
                  +y+++t+ +  s      ++  + +q  + + il+  k+  +   + s+e+++l+ ++l+k++++R+ta++ll+ +y+
  EFC38128.1 1152 IYQIMTKDETTS-----ISNLLMGNQSSNAQTILT--KQMRNCSISYSNELIQLILQMLDKNRETRPTAQQLLKFDYF 1222
                  *********999.....222345555556677774..4666777788***************************9997 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.66   1.7e+03      76     120 ..     714     759 ..     650     761 .. 0.68
   2 !  126.4   0.3   4.6e-40   1.2e-36       4     257 ..     967    1218 ..     964    1219 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.66
                  EEEEEE--TTEBHH.HHHHHTCTTTSBHHHHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr  76 llivteyvkgGdLl.kfLrkkekekltlkdllsfalqvAkGmeyLe 120
                     vt++ + G++l ++  ++++   ++++ll+++ ++A+G  yL 
   EFC38128.1 714 DGPVTNFTNFGTILfSYSSNEDSIYYCTSTLLRVIEKMANGTYYLR 759
                  45577777777644155555566677899999*********99996 PP

  == domain 2  score: 126.4 bits;  conditional E-value: 4.6e-40
                   EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE.SSSSEEEEEE--TTEBHHHHHHHTCTT CS
  Pkinase_Tyr    4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct.keepllivteyvkgGdLlkfLrkkeke 98  
                    +++G+GafG+V++++ +   +  +   avK++k e+ ++  + +++ea+ ++++khpni+k+    + +++ l+i ++y ++GdL++fL+++   
   EFC38128.1  967 IERIGQGAFGSVYKANDS---KAGNRIKAVKVIKFESFSD-LNTIMKEASQLSHIKHPNILKVNDYFItQDSLLCIDMDYYESGDLNQFLKRE--- 1055
                   689************988...55555669****8877776.9**********************9988355668889**************99... PP

                   TSBHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHH CS
  Pkinase_Tyr   99 kltlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvW 189 
                    ++ + + ++  q ++G++y++s+ +++Hrd+   N++++     n  + i+DfGLa+++    +  k ++      +m+pE+   ++++ ++D++
   EFC38128.1 1056 -CSENIIKQILKQSCEGLNYIHSQlSIIHRDIKPSNIFVKYlkndNIEIVIADFGLAKKH----QEMKGQSYVGTPLFMSPEIALGSSYSFNTDIF 1146
                   .77777888999**********98469************96555477899********99....55566666777789****************** PP

                   HHHHHHHHHHTTSSGT.TTTS...HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr  190 sfGvllwEiftlgesp.ypgl...kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselve 257 
                   s Gv ++ i+t+ e++ +++l   ++++ ++++ +++  ++  + ++el +l+ + ++++ e Rpt ++l++
   EFC38128.1 1147 SLGVSIYQIMTKDETTsISNLlmgNQSSNAQTILTKQMRNCSISYSNELIQLILQMLDKNRETRPTAQQLLK 1218
                   ***********88765333323234445556666666667778899*********************99975 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.0   1.5e-07   0.00039       1      27 [.      23      49 ..      23      50 .. 0.94
   2 !   20.9   0.0   9.6e-08   0.00025       1      28 []      64      91 ..      64      91 .. 0.97
   3 ?    2.4   0.0     0.073   1.9e+02       1      27 [.     225     250 ..     225     251 .. 0.90
   4 !    7.0   0.0    0.0024       6.2       6      23 ..     671     689 ..     669     690 .. 0.88
   5 ?    1.5   0.0      0.14   3.7e+02       2      19 ..     782     799 ..     781     802 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 1.5e-07
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                fn P++++v++nGd+y+aD+ n+ +++
  EFC38128.1 23 FNTPSSLSVSPNGDLYIADTQNNKIRI 49
                899*******************99986 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 9.6e-08
                BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28
                fn P G++v+sn+ +y+aD+ n+ ++++
  EFC38128.1 64 FNKPLGIVVSSNNILYIADTQNNLIKKY 91
                99***********************987 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.073
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f++P+++++ +n  +y  D  n+++++
  EFC38128.1 225 FYNPSSLVL-KNSIVYLVDQTNNCIRK 250
                 899999999.9********99999986 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0024
                 EEEEE.TTTEEEEEECCCT CS
         NHL   6 Gvavd.snGdiyVaDsenh 23 
                 G++v+  nGdiy +Ds ++
  EFC38128.1 671 GLSVNpENGDIYLSDSTSF 689
                 99*************8765 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.14
                 SSEEEEEEETTTEEEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaD 19 
                 ++P +  v +nGdi++ D
  EFC38128.1 782 SSPISFYVKKNGDIIILD 799
                 5677777889*******9 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   0.0   3.3e-09   8.4e-06     312     398 ..    1065    1146 ..    1051    1148 .. 0.86

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 3.3e-09
  Pkinase_fungal  312 lrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhDLE 398 
                      l++  +g++  +++  i+HrDi   Ni +    k+++ + +++D+ lak++++ + +s     +GT+ Fm+ e+  g++ s+  D+ 
      EFC38128.1 1065 LKQSCEGLNYIHSQLSIIHRDIKPSNIFVK-YLKNDNIEIVIADFGLAKKHQEMKGQS----YVGTPLFMSPEIALGSSYSFNTDIF 1146
                      6667788888999999***********999.66777999*************865555....69***********999999999985 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   1.3     6e-05      0.15      13     164 ..      77     254 ..      25     260 .. 0.81
   2 ?   -3.4   0.0       2.3   5.8e+03      43      74 ..     338     367 ..     324     374 .. 0.72
   3 ?   -4.2   0.0       3.8   9.8e+03     138     157 ..     671     690 ..     670     694 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6e-05
         SGL  13 aLlwvDilgqrihrldpatgketv.....................ldtpesvGaiaprkdgrlvvasksglalldlasgeletladeeedekpllrfND 90 
                  L+  D +++ i ++d +t+  ++                     ++ p+ + ++ + k+++++++ ++++ ++d ++g+++++        p+  +  
  EFC38128.1  77 ILYIADTQNNLIKKYDISTRVLSTiggekayldgsydnvdansviMKSPKNIHVVSNGKEDTVYFTDEERVKRID-SNGKYRVVDGL----SPQSNLYG 170
                 455555555555555555555555666666666666666666666999999999999999**************9.66777655443....48889999 PP

         SGL  91 gvvdpdGrlwfGtmgdeeakgeev...........galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvd 164
                 + v + +++w ++++ + +++++v             ly +++d  l    +++ + N   +   ++ +Yl+D ++++i ++d  
  EFC38128.1 171 IFVTSSNEIWTTSPSSHFVQMKSVgsavqstfigqQDLYGYEGD-DLIDSYSKVLFYNPSSLVLKNSIVYLVDQTNNCIRKIDTR 254
                 9*********************9999999999999999999999.999999*****************************99975 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.3
         SGL  43 vGaiaprkdgrlvvasksglalldlasgelet 74 
                 +++i+p  +g +v+  +++++l+++++ +l+ 
  EFC38128.1 338 NTYIFP--NGDMVIVTSTDVFLFNIYTEQLSS 367
                 445555..788888888888888888877765 PP

  == domain 3  score: -4.2 bits;  conditional E-value: 3.8
         SGL 138 GlawspdgktlYlaDsltrk 157
                 Gl ++p++  +Yl Ds+ ++
  EFC38128.1 671 GLSVNPENGDIYLSDSTSFR 690
                 8899999********99876 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.1   9.8e-06     0.025     104     166 ..    1045    1107 ..    1037    1115 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 9.8e-06
  YrbL-PhoP_reg  104 dGnvaktLedlvkkeeltaelkeaLdefleelldnhivtndlsakNivvkknsegeeelvlvD 166 
                      G++ ++L++ ++++ +++ lk+  + +     ++ i+ +d++++Ni+vk+ ++++ e+v+ D
     EFC38128.1 1045 SGDLNQFLKRECSENIIKQILKQSCEGLNYIHSQLSIIHRDIKPSNIFVKYLKNDNIEIVIAD 1107
                     6999999*********************9999************************9999988 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   7.4e-05      0.19     104     170 ..    1047    1112 ..    1028    1121 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 7.4e-05
         Kdo  104 dLedllakwaelaeelkrallkavgrliaklhr.agvnHadlyaknillqqeeeeeaeiwliDldkar 170 
                  dL+++l++  e +e+  +++lk+     + +h+ + + H+d+ + ni+++  +++++ei++ D+  a+
  EFC38128.1 1047 DLNQFLKR--ECSENIIKQILKQSCEGLNYIHSqLSIIHRDIKPSNIFVKYLKNDNIEIVIADFGLAK 1112
                  78888886..899999999999999999999973689**************************97665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1223 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       690  (0.0384851); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.83u 0.30s 00:00:01.12 Elapsed: 00:00:00.48
# Mc/sec: 7679.17
//
Query:       EFC38129.1  [L=1395]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-43  148.8   0.0    2.6e-43  148.3   0.0    1.2  1  Pkinase      Protein kinase domain
    1.4e-24   86.8   0.0      2e-24   86.3   0.0    1.3  1  Pkinase_Tyr  Protein tyrosine kinase
      8e-16   58.1 130.3    9.1e-05   22.7   4.5    9.5  9  EGF_2        EGF-like domain
    6.4e-15   54.3   3.0    0.00087   19.2   0.0    8.3  8  NHL          NHL repeat
     0.0012   18.2   0.0      0.002   17.5   0.0    1.2  1  Kdo          Lipopolysaccharide kinase (Kdo/WaaP) family
     0.0028   17.9  15.4     0.0032   17.7   4.4    8.5  9  EGF          EGF-like domain
  ------ inclusion threshold ------
      0.055   13.7   0.0       0.15   12.3   0.0    1.8  1  DUF4536      Domain of unknown function (DUF4536)
        0.2   11.2   0.3         20    4.6   0.0    3.1  3  PQQ_2        PQQ-like domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  148.3   0.0   1.2e-46   2.6e-43       1     260 [.    1114    1388 ..    1114    1390 .. 0.84

  Alignments for each domain:
  == domain 1  score: 148.3 bits;  conditional E-value: 1.2e-46
                  EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSE..EEEEEE--TTEBHHHHHHHHSS. CS
     Pkinase    1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekde..lylvleyveggeladllerkgs. 94  
                  y+ ++klG+G++G+V+  +e +t++ +AvK+i++ +   ++ k+v++  ++ ++ + p+iv ++++   +++  +++++ + +++ l ++++++++ 
  EFC38129.1 1114 YVLVKKLGSGAYGSVFIFKEITTDELFAVKQIEVTNPFGSEFKEVVNMYELSEE-SNPFIVPILGCTMVENSlfICIIMPLYKCD-LRNWIHTHQNq 1208
                  67789*******************************999887666654444443.379****9987665555116699*****98.99999955555 PP

                  --HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET...............TTE..EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCB CS
     Pkinase   95 lseeeakkiakqilegleylHskgiiHrDlKpeNiLide...............kge..lKitDFGlakelessskltsfvgtseYlAPEvlkeney 174 
                  ++ e + +i+kqi+++l+ylHskg++HrDlK+ Ni+i +               +++  l ++D+G +++ ++s+ lt + gt +Y APE + + e+
  EFC38129.1 1209 IPIELVLEIIKQIASALDYLHSKGMVHRDLKQTNIFIAKapenpqsssksilewNNDflLCVGDWGSSRHQHRSN-LTAYEGTLQYSAPEAIIKGEF 1304
                  **************************************76777777666666653337899************98.********************* PP

                  SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase  175 skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellq 260 
                  ++++D+WslG+i+y+ll+g       + k+  + e+d+ + +  i+ + ++k++ + e+ e + dll +++++dp +R++ +++lq
  EFC38129.1 1305 GPPSDIWSLGCIVYQLLSGDYASVLLRVKQ-GNDEADTKVLLPAIV-QFSKKVKYQGEVFELCCDLLWEMIRYDPASRISPSQILQ 1388
                  *******************97666444443.445666645555555.557889999999*************************98 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.3   0.0   8.7e-28     2e-24       3     203 ..    1116    1324 ..    1114    1390 .. 0.80

  Alignments for each domain:
  == domain 1  score: 86.3 bits;  conditional E-value: 8.7e-28
                   EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS...-BTTB--EEEEEESSSS..EEEEEE--TTEBHHHHHH CS
  Pkinase_Tyr    3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl...khpnivkllgvctkeep..llivteyvkgGdLlkfLr 93  
                   l kklG+Ga+G+V+  +      ++++  avK+++ ++     +e+ +e+  m +l   ++p iv +lg+ + e++  ++i++ + k  dL++ ++
   EFC38129.1 1116 LVKKLGSGAYGSVFIFKEI----TTDELFAVKQIEVTNPFG--SEF-KEVVNMYELseeSNPFIVPILGCTMVENSlfICIIMPLYK-CDLRNWIH 1203
                   679***********88777....88999******5544443..333.4444444443227889********9555545888888876.59****** PP

                   HTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.................TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS CS
  Pkinase_Tyr   94 kkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.................nkvvkisDfGLardiekddeyvkkeeaklpvkWm 172 
                   ++ ++++ ++ +l+++ q+A++++yL+sk +vHrdl   N+++++                 + +  ++D G +r+  ++++    +  +  +++ 
   EFC38129.1 1204 TH-QNQIPIELVLEIIKQIASALDYLHSKGMVHRDLKQTNIFIAKapenpqsssksilewnnDFLLCVGDWGSSRHQ-HRSNL---TAYEGTLQYS 1294
                   **.*********************************************************977799******99988.44444...44556799** PP

                   -HHHHHHSEEEHHHHHHHHHHHHHHHHTTSS CS
  Pkinase_Tyr  173 apEslkekkftsksDvWsfGvllwEiftlge 203 
                   apE++ +++f   sD+Ws G +++ +++ g+
   EFC38129.1 1295 APEAIIKGEFGPPSDIWSLGCIVYQLLS-GD 1324
                   *************************998.54 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.2      0.78   1.7e+03       9      19 ..     505     513 ..     498     520 .. 0.77
   2 !   17.2  11.3   2.2e-06    0.0049       1      30 [.     694     722 ..     694     723 .. 0.92
   3 ?    3.3   2.6     0.049   1.1e+02      22      32 .]     748     758 ..     740     758 .. 0.81
   4 !   22.7   4.5   4.1e-08   9.1e-05       5      30 ..     771     795 ..     767     796 .. 0.84
   5 ?    5.0   5.8     0.015        33       5      32 .]     803     829 ..     798     829 .. 0.83
   6 !   18.4  12.0     9e-07     0.002       6      32 .]     843     868 ..     838     868 .. 0.83
   7 !   10.0  15.6   0.00039      0.87       6      32 .]     877     902 ..     873     902 .. 0.85
   8 !   14.9   9.4   1.1e-05     0.026       7      32 .]     915     939 ..     907     939 .. 0.91
   9 !   13.2   8.3   3.8e-05     0.085       7      32 .]     958     990 ..     952     990 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.78
       EGF_2   9 gghGtCvnqcG 19 
                 +++G C+   G
  EFC38129.1 505 SNNGNCN--DG 513
                 799***9..55 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 2.2e-06
       EGF_2   1 Csas.deiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C +s +  C+ghG Cv  +G C C sg+ G+
  EFC38129.1 694 CIDSqGQVCSGHGDCV--NGSCACLSGWRGN 722
                 7778899*********..***********97 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.049
       EGF_2  22 dCdsgyqGktC 32 
                 +C sg++G+ C
  EFC38129.1 748 SCTSGWYGDLC 758
                 7*********9 PP

  == domain 4  score: 22.7 bits;  conditional E-value: 4.1e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++ C+ hGtCv+ +  C C+sg+ G+
  EFC38129.1 771 SLVCNSHGTCVSNN-TCLCQSGWKGN 795
                 789*******9555.9********97 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.015
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++i ++hG+Cv ++   dC+ g+ G+ C
  EFC38129.1 803 CDIPSQHGICVGPN-IYDCEEGWVGNLC 829
                 677799*****999.55*********99 PP

  == domain 6  score: 18.4 bits;  conditional E-value: 9e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ +G+C++ +  C+Cdsg+ G  C
  EFC38129.1 843 TCCNSNGKCISNN-TCKCDSGWEGQLC 868
                 44999****9555.9**********99 PP

  == domain 7  score: 10.0 bits;  conditional E-value: 0.00039
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ hG+C++ +  C+C+s y G++C
  EFC38129.1 877 NNCQPHGSCISNN-TCKCNSEYGGNDC 902
                 68*******9555.9************ PP

  == domain 8  score: 14.9 bits;  conditional E-value: 1.1e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ +G+Cv+++ +C+C++ y+G tC
  EFC38129.1 915 GCNDQGVCVSFN-KCSCFPFYFGETC 939
                 3********999.************* PP

  == domain 9  score: 13.2 bits;  conditional E-value: 3.8e-05
       EGF_2   7 iCgghGtCvnqcG.......qCdCdsgyqGktC 32 
                  C+ +G Cv + +       +C+Cd+gy+Gk C
  EFC38129.1 958 RCSSNGLCVLSQNasnqnstKCQCDDGYSGKFC 990
                 5*******6444468998888************ PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.0    0.0021       4.6       1      23 [.     147     170 ..     147     171 .. 0.92
   2 ?    2.4   0.1      0.08   1.8e+02      12      25 ..     209     222 ..     209     224 .. 0.88
   3 ?    3.5   0.0     0.036        81       2      28 .]     261     286 ..     260     286 .. 0.76
   4 ?   -0.1   0.0      0.51   1.1e+03      14      25 ..     476     487 ..     474     488 .. 0.84
   5 !   12.1   0.0   6.9e-05      0.15       1      27 [.     568     594 ..     568     595 .. 0.93
   6 !   19.2   0.0   3.9e-07   0.00087       1      27 [.     623     649 ..     623     650 .. 0.94
   7 ?   -2.8   0.0       3.8   8.5e+03       5      12 ..     809     816 ..     809     816 .. 0.86
   8 ?   -2.4   0.1       2.8   6.2e+03       2      11 ..     879     888 ..     878     889 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0021
                 BSSEEEEEEE.TTTEEEEEECCCT CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenh 23 
                 + +P+Gv +d s++ +++ D +n+
  EFC38129.1 147 LTSPSGVYLDeSTNSLFILDVYNF 170
                 568*****************9995 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.08
                 TTEEEEEECCCTEE CS
         NHL  12 nGdiyVaDsenhrv 25 
                 nG +y+ Ds+n+ +
  EFC38129.1 209 NGIFYIVDSGNNFI 222
                 799********977 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.036
                 SSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 ++P+++a+ s++  +V Ds+ +r+ +F
  EFC38129.1 261 SNPTSIAL-SSDGMIVVDSGYNRLLQF 286
                 58******.677777778777777766 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.51
                 EEEEEECCCTEE CS
         NHL  14 diyVaDsenhrv 25 
                  +++aDs n+ +
  EFC38129.1 476 GLLIADSANNLI 487
                 689******988 PP

  == domain 5  score: 12.1 bits;  conditional E-value: 6.9e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+++ +++nGd+y+a+s+ +++ +
  EFC38129.1 568 LNYPTSLFYTPNGDLYIANSGGNQILK 594
                 79******************9999975 PP

  == domain 6  score: 19.2 bits;  conditional E-value: 3.9e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 ++yP  v+v+snG i++aDs+n+ +++
  EFC38129.1 623 LSYPLAVTVTSNGVIFIADSGNNAIRK 649
                 689********************9986 PP

  == domain 7  score: -2.8 bits;  conditional E-value: 3.8
                 EEEEEETT CS
         NHL   5 hGvavdsn 12 
                 hG++v +n
  EFC38129.1 809 HGICVGPN 816
                 9****976 PP

  == domain 8  score: -2.4 bits;  conditional E-value: 2.8
                 SSEEEEEEET CS
         NHL   2 nyPhGvavds 11 
                 ++PhG ++++
  EFC38129.1 879 CQPHGSCISN 888
                 9****88864 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   8.7e-07     0.002     104     154 ..    1197    1248 ..    1154    1258 .. 0.91

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 8.7e-07
         Kdo  104 dLedllakwae.laeelkrallkavgrliaklhragvnHadlyaknillqqe 154 
                  dL +++ ++++ ++ el  +++k+++ +   lh+ g+ H+dl   ni++ ++
  EFC38129.1 1197 DLRNWIHTHQNqIPIELVLEIIKQIASALDYLHSKGMVHRDLKQTNIFIAKA 1248
                  899999999889999*********************************9876 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.6       1.5   3.3e+03       7      22 ..     505     519 ..     505     520 .. 0.84
   2 !    9.6   4.2   0.00049       1.1       5      31 ..     700     722 ..     696     723 .. 0.88
   3 ?   -3.2   0.2       4.9   1.1e+04      24      31 ..     749     756 ..     747     756 .. 0.86
   4 !   15.5   3.3     7e-06     0.016       5      31 ..     770     795 ..     768     796 .. 0.88
   5 ?   -1.9   0.0         2   4.5e+03      23      31 ..     819     827 ..     819     828 .. 0.88
   6 !    9.5   6.5   0.00053       1.2       5      30 ..     843     865 ..     839     867 .. 0.88
   7 ?   -2.9  14.3       4.1   9.2e+03       1      31 [.     873     900 ..     868     901 .. 0.89
   8 ?   -1.0   2.1         1   2.3e+03       6      30 ..     916     936 ..     910     938 .. 0.75
   9 !   17.7   4.4   1.4e-06    0.0032       4      31 ..     956     988 ..     944     989 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.5
                 TTT-EEEEETTTEEEE CS
         EGF   7 sngGtCvdtgrggytC 22 
                 sn+G C d+  +  +C
  EFC38129.1 505 SNNGNCNDGL-PATSC 519
                 6999999998.99999 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00049
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                   Cs++G Cv+++     C C +G+ G+
  EFC38129.1 700 QvCSGHGDCVNGS-----CACLSGWRGN 722
                 46***********.....********97 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 4.9
                 ECTTEEST CS
         EGF  24 CpeGytGk 31 
                 C++G+ G+
  EFC38129.1 749 CTSGWYGD 756
                 99**9995 PP

  == domain 4  score: 15.5 bits;  conditional E-value: 7e-06
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                 +   C+ +GtCv++     tC C++G++G+
  EFC38129.1 770 NslvCNSHGTCVSNN----TCLCQSGWKGN 795
                 4555***********....*********97 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 2
                 EECTTEEST CS
         EGF  23 iCpeGytGk 31 
                 +C eG+ G+
  EFC38129.1 819 DCEEGWVGN 827
                 6*****997 PP

  == domain 6  score: 9.5 bits;  conditional E-value: 0.00053
                 T.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytG 30 
                 + C+ +G+C+++     tC+C++G+ G
  EFC38129.1 843 TcCNSNGKCISNN----TCKCDSGWEG 865
                 46*******9999....********99 PP

  == domain 7  score: -2.9 bits;  conditional E-value: 4.1
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  n+C+ +G C+++     tC+C + y G+
  EFC38129.1 873 CDGvNNCQPHGSCISNN----TCKCNSEYGGN 900
                 666688*******9999....********997 PP

  == domain 8  score: -1.0 bits;  conditional E-value: 1
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 C+ +G Cv+      +C C + y+G
  EFC38129.1 916 CNDQGVCVSFN----KCSCFPFYFG 936
                 999****8877....7888765555 PP

  == domain 9  score: 17.7 bits;  conditional E-value: 1.4e-06
                 TT.STTT-EEEEET....TTEEEEEECTTEEST CS
         EGF   4 np.CsngGtCvdtg....rggytCiCpeGytGk 31 
                 ++ Cs +G Cv ++     ++ +C+C+ Gy+Gk
  EFC38129.1 956 TKrCSSNGLCVLSQnasnQNSTKCQCDDGYSGK 988
                 337*****************************8 PP

>> DUF4536  Domain of unknown function (DUF4536)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   6.8e-05      0.15      10      30 ..    1013    1033 ..    1010    1041 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.8e-05
     DUF4536   10 GsGLigaGvYvyvqarrrlkl 30  
                  +s+Lig+Gv+vy+  +rr+k 
  EFC38129.1 1013 SSALIGIGVFVYFKKFRRNKN 1033
                  589***********9999875 PP

>> PQQ_2  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.009        20      29      95 ..     264     332 ..     242     376 .. 0.77
   2 ?    2.4   0.0     0.045     1e+02     160     202 ..     405     444 ..     397     494 .. 0.78
   3 ?   -0.7   0.1      0.38   8.4e+02      55      96 ..     614     654 ..     577     683 .. 0.63

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.009
       PQQ_2  29 vsravlsggtlfvatgggrlvaldaatGkvlWettl....egpvvgaplvaegrvvvvasdgqlialdaed 95 
                 +s a+ s+g ++v +g++rl +++  t  ++ + +     ++p++ + l  +   vv +++gql+ +++++
  EFC38129.1 264 TSIALSSDGMIVVDSGYNRLLQFS--TNGIVYNWANfapiTNPLHIISLGYDSSYVVSTGGGQLLLFNQTT 332
                 555677889999999999999998..444444444403455555555888888888888888999998876 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.045
       PQQ_2 160 srvgdisgrpvvaegtVyassgqgrllaldlatgrrlwskeis 202
                 s+++ +++  v+++ +Vy  s+q  +l+ldl+tg    ++ i+
  EFC38129.1 405 SFLRNLNQLQVISDSEVYLTSYQSAVLKLDLKTGF---ANVIA 444
                 46777777778887899999999999999999997...44444 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.38
       PQQ_2  55 tGkvlWettlegpvvgaplvaegrvvvvasdg.qlialdaedG 96 
                 +Gk+  +++l+ p+  +   ++g ++ ++s++ ++++++ +dG
  EFC38129.1 614 DGKQATSAQLSYPLAVT-VTSNGVIFIADSGNnAIRKIN-TDG 654
                 45555555555553333.444444444444443444444.444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1395 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       706  (0.0393775); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.99u 0.36s 00:00:01.35 Elapsed: 00:00:00.54
# Mc/sec: 7776.99
//
Query:       EFC38130.1  [L=210]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.048   13.0   0.9      0.063   12.6   0.9    1.2  1  APO_RNA-bind  APO RNA-binding


Domain annotation for each model (and alignments):
>> APO_RNA-bind  APO RNA-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.9   3.5e-06     0.063      24      91 ..     125     189 ..     104     204 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.5e-06
  APO_RNA-bind  24 kekkPfPiPlkelrraaredkklakkkiekklepPknGllvkelvpvayevldarkllikglkkllkv 91 
                   ++ +P Pi  k+ +++++e+k++ ++++e   ep ++ l++++l  v  + l++ ++++  +k l+++
    EFC38130.1 125 ENERPLPIDTKKKKQSSHERKRKLDMSVE---EPRRRKLFIQQLTSVKLHTLNSSRMVMMLMKILMEI 189
                   4568***********99999999988776...578899*********999999887776666555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (210 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1033  (0.0576162); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.29s 00:00:00.70 Elapsed: 00:00:00.45
# Mc/sec: 1407.09
//
Query:       EFC38131.1  [L=447]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.2e-67  225.4   0.0      1e-66  224.9   0.0    1.2  1  Tubulin    Tubulin/FtsZ family, GTPase domain
    1.4e-49  167.5   0.1    2.3e-49  166.8   0.1    1.4  1  Tubulin_C  Tubulin C-terminal domain
     0.0086   15.8   0.0      0.024   14.3   0.0    1.8  1  Tubulin_3  Tubulin domain
  ------ inclusion threshold ------
       0.23   10.6   0.3       0.39    9.9   0.3    1.2  1  Tubulin_2  Tubulin like


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  224.9   0.0   2.3e-70     1e-66       1     196 [.       3     212 ..       3     213 .. 0.99

  Alignments for each domain:
  == domain 1  score: 224.9 bits;  conditional E-value: 2.3e-70
                 EEEEEEEHHHHHHHHHHHHH...HHHCH...............HHHT.....TTEEEEE....EEESBHHHHHTS-GS........EEEE--CCCCTTC CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiqsdg...........dslesfFsesgkveyiprsvaidtdpqvlneikags..elfnpnklllgkegagnn 86 
                 e+i i++Gq+G+q+gn++wel++ ehgiqsdg           ds ++fFse+g ++ +pr+v++d++p+v++e+++g+  +lf+p++l++gke+a+nn
  EFC38131.1   3 EVISIHIGQAGVQLGNACWELYCLEHGIQSDGmkpsdksfgydDSNDTFFSETGIGKHVPRAVFLDLEPTVVDEVRTGTyrQLFHPDQLISGKEDAANN 101
                 799**************************999******************************************************************* PP

                 --TT-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--.GG.G-HHHHHHHHHHHHHHHHT-SEE CS
     Tubulin  87 gaggypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs.efsevvvepynailalkelieesdav 184
                 +a+g++++gke+ + +l++irk +++c  lqgf++++s+gGGTGSGlg+++le+l+ +y k++++++ ++Ps ++ + vvepyn++l++++l e+sd+ 
  EFC38131.1 102 YARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFSSVGGGTGSGLGALLLERLSVDYGKKPKLNFTIYPSpQIATAVVEPYNSVLSTHALLEHSDVS 200
                 *************************************************************************************************** PP

                 EEEEHHHHHCCS CS
     Tubulin 185 ividNdaLlkil 196
                 +++dN+a+++i+
  EFC38131.1 201 VILDNEAIYDIC 212
                 ***********9 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  166.8   0.1   5.1e-53   2.3e-49       1     125 [.     262     391 ..     262     392 .. 0.99

  Alignments for each domain:
  == domain 1  score: 166.8 bits;  conditional E-value: 5.1e-53
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEESSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEECECT CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirGdvepkevnkavqrikekkkaqfveWiptgikvalnkkspy 99 
                 Pr+hF+l+sy+P++saeka +e++sv+++t+a++ep ++m+k+dpr+gky+a++l++rGdv+pk+vn+avq+ik+k+++qfv+W+ptg+k+++n+++p 
  EFC38131.1 262 PRIHFMLSSYSPIISAEKAYHERLSVSEITNAVFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNSAVQTIKHKRTVQFVDWSPTGFKCGINYQAPS 360
                 9************************************************************************************************** PP

                 -TTTS.....SCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C 100 vkkqs.....kvsvlmlaNttsiaelfkrll 125
                 v+++       ++v+m++N+t+iae+f+r++
  EFC38131.1 361 VVPGGdlakvMRAVCMISNSTAIAEVFSRID 391
                 ****99999999*****************97 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   5.4e-06     0.024      58     106 ..     115     164 ..      87     199 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 5.4e-06
   Tubulin_3  58 dl.ldrdlrpfaeecdqlrglqvftgvddaWG.Gfaakylerlrdeygkks 106
                 dl ldr +r++a++c  l+g+ vf++v    G G +a  lerl  +ygkk 
  EFC38131.1 115 DLcLDR-IRKLADNCTGLQGFLVFSSVGGGTGsGLGALLLERLSVDYGKKP 164
                 552555.9*******************9887769***************96 PP

>> Tubulin_2  Tubulin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.3   8.7e-05      0.39     138     172 ..     116     148 ..     105     154 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 8.7e-05
   Tubulin_2 138 alrdaikrlrgsage.eeglnvfVvgSLaGGTGSGi 172
                  + d+i++l++   + +++  + V++S+ GGTGSG+
  EFC38131.1 116 LCLDRIRKLAD---NcTGLQGFLVFSSVGGGTGSGL 148
                 44444444444...335567799************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (447 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       427  (0.0238162); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2830.81
//
Query:       EFC38132.1  [L=569]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-13   48.6  23.2      0.006   16.3   0.0    9.1  8  DUF4116   Domain of unknown function (DUF4116)
     0.0041   17.0   0.1        2.3    8.2   0.0    4.0  5  DUF3658   Protein of unknown function


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.4   0.2     0.007        63       7      47 ..      97     143 ..      91     157 .. 0.72
   2 !    6.1   0.0     0.001       9.4       6      21 ..     192     207 ..     185     209 .. 0.62
   3 !   16.3   0.0   6.7e-07     0.006       9      45 ..     219     255 ..     214     260 .. 0.90
   4 !   12.6   0.0   9.2e-06     0.082      15      46 ..     283     314 ..     271     317 .. 0.87
   5 !    7.1   0.0   0.00048       4.3       8      45 ..     327     366 ..     325     371 .. 0.74
   6 !    3.0   0.8    0.0091        82       5      35 ..     350     381 ..     346     392 .. 0.79
   7 ?    2.0   0.2     0.019   1.7e+02      13      33 ..     431     450 ..     414     476 .. 0.79
   8 !    4.2   3.9    0.0039        35       6      32 ..     530     557 ..     492     563 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.007
     DUF4116   7 eavkkngsalkylseeLknDkeivlkAvkqngt.......alsyasee 47 
                 ++v+ n+  l++l  ++k++ ++v+ A+k+  +       al+ + ee
  EFC38132.1  97 KYVEENPGELHKLQ-KWKSNENVVKSACKNFRDqspdqfiALRNLIEE 143
                 56666666677776.899***********7654444455555555555 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.001
     DUF4116   6 leavkkngsalkylse 21 
                  e++++ng +l+++s+
  EFC38132.1 192 EEIISRNGDVLEFISP 207
                 4555566666666554 PP

  == domain 3  score: 16.3 bits;  conditional E-value: 6.7e-07
     DUF4116   9 vkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 vk++g+++++l+ ++ +D +++  Av qn++al y+ 
  EFC38132.1 219 VKQDGLIIRFLPASYMKDQQLIASAVMQNPKALVYCF 255
                 9*******************************99976 PP

  == domain 4  score: 12.6 bits;  conditional E-value: 9.2e-06
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyase 46 
                  ++yl+e  ++ +e++ +Avk +g  l+++++
  EFC38132.1 283 GYQYLPEHVRKRIELAHEAVKYDGRLLEFVPK 314
                 59****************************97 PP

  == domain 5  score: 7.1 bits;  conditional E-value: 0.00048
     DUF4116   8 avkkngsalkylseeL.knDkeivlkAvkqng.talsyas 45 
                 a+k + +al+++s+e+  ++  ++  ++  n    l +++
  EFC38132.1 327 ALKVHANALQFVSDEFqLQHESLIESCLSLNVvETLQFCH 366
                 8889999999999999666777777788777766777766 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.0091
     DUF4116   5 vleavkkn.gsalkylseeLknDkeivlkAvk 35 
                 +  +++ n  + l+++ +++ + k ++l A+k
  EFC38132.1 350 IESCLSLNvVETLQFCHSKYLQKKKFILNALK 381
                 5556666634689*****************99 PP

  == domain 7  score: 2.0 bits;  conditional E-value: 0.019
     DUF4116  13 gsalkylseeLknDkeivlkA 33 
                 + +++ ++ e++nD  ++ kA
  EFC38132.1 431 PDNIELVN-EISNDNMFIEKA 450
                 66676666.99*******997 PP

  == domain 8  score: 4.2 bits;  conditional E-value: 0.0039
     DUF4116   6 leavkkngs.alkylseeLknDkeivlk 32 
                 l++++++ + +++yls++ +n+ke +++
  EFC38132.1 530 LKLIDSDYYhIINYLSDSKRNNKEYAME 557
                 6677777555899999999999999987 PP

>> DUF3658  Protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0   0.00025       2.3      47      96 ..      91     152 ..      80     160 .. 0.80
   2 ?   -0.4   0.0      0.11     1e+03      47      70 ..     222     245 ..     219     252 .. 0.87
   3 ?    2.7   0.0     0.012   1.1e+02      44      80 ..     302     342 ..     294     351 .. 0.91
   4 ?   -3.2   0.0      0.89     8e+03      51      72 ..     377     404 ..     361     407 .. 0.57
   5 ?   -2.2   0.0      0.41   3.7e+03      30      57 ..     426     453 ..     424     463 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00025
     DUF3658  47 Ddlileaakke..........wqkaarligevlghldqfisDefleyR..ireLikaGvlel 96 
                 D++++ +  +e          w++  +++ ++ ++++ +  D+f++ R  i+eLi+++ l+ 
  EFC38132.1  91 DEILMCKYVEEnpgelhklqkWKSNENVVKSACKNFRDQSPDQFIALRnlIEELIQKKSLNE 152
                 555554333334777777777***************************999*****999875 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.11
     DUF3658  47 Ddlileaakkewqkaarligevlg 70 
                 D li++++++ ++k ++li++++ 
  EFC38132.1 222 DGLIIRFLPASYMKDQQLIASAVM 245
                 899****************99765 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.012
     DUF3658  44 dyfDdlileaakke....wqkaarligevlghldqfisDef 80 
                  ++D  +le+++k     +++++++  +v ++  qf+sDef
  EFC38132.1 302 VKYDGRLLEFVPKTpiniFESSSETALKVHANALQFVSDEF 342
                 579****************************999*****99 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 0.89
     DUF3658  51 leaakke......wqkaarligevlghl 72 
                 l+a+k+       + +   +ig++++++
  EFC38132.1 377 LNALKELrkddsiMSSGLTVIGNMINRM 404
                 4444444444443334445666666665 PP

  == domain 5  score: -2.2 bits;  conditional E-value: 0.41
     DUF3658  30 LRiwkdgklvsveedyfDdlileaakke 57 
                  Ri++ ++++ v+e   D++ +e+a+ +
  EFC38132.1 426 TRIVNPDNIELVNEISNDNMFIEKAAVD 453
                 6999999999999999999999998766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (569 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       655  (0.036533); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.27s 00:00:00.92 Elapsed: 00:00:00.47
# Mc/sec: 3644.41
//
Query:       EFC38133.1  [L=479]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.1e-05   22.4   1.4    0.00029   20.6   0.6    2.2  2  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.019   14.5   0.4      0.033   13.7   0.4    1.4  1  LIDHydrolase   Lipid-droplet associated hydrolase
       0.02   13.6   0.2      0.049   12.3   0.2    1.7  1  Ndr            Ndr family
        0.1   11.8   0.0       0.18   11.0   0.0    1.3  1  Hydrolase_4    Serine aminopeptidase, S33


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.6   6.4e-08   0.00029       1     107 [.      69     194 ..      69     217 .. 0.76
   2 ?   -1.7   0.0       0.4   1.8e+03     239     239 ..     304     304 ..     232     418 .. 0.60

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 6.4e-08
                    SEEEEE-STTTCGGGGTTGHHHHHHHHT..TSEEEEEEETTSTTSSSTTTGB.CHH...................SHHHHHHHHHHHHHHCTTSSE CS
  Abhydrolase_1   1 pvlvilhGlpgssdvwaerglapaLakd..gfdvillDlrGvgySspapacinddy...................gtasvaddldrildalgddkl 75 
                    p+l+ilh ++gss+ +++   ++ + ++  +f++i +  + ++ +        +++                   +   + + +     + + + +
     EFC38133.1  69 PPLIILHDFCGSSHDFYN--QFSMIFDEgkDFHFISVEIPSHCTTIDEFV---PEFdkfvnlvsnsssnhifsisPQLRFSEPISISNSKSKSQCV 159
                    799***************..555565556699999999999999955555...5556668888888888555555555555555555666666666 PP

                    EEEEETHHHHHHHHHHHHHGGGEEEEEEESE...C CS
  Abhydrolase_1  76 tlvGhSmGGmialayaaeyperVkalvllga...i 107
                    +l G+ +G ++al+ya+ey e+V++l+l+++   +
     EFC38133.1 160 HLCGCGLGAFLALNYASEYVEKVSSLILVNGfvnS 194
                    6*****************************95331 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.4
                    S CS
  Abhydrolase_1 239 k 239
                    +
     EFC38133.1 304 S 304
                    1 PP

>> LIDHydrolase  Lipid-droplet associated hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.4   7.4e-06     0.033      16     250 ..      83     315 ..      80     328 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 7.4e-06
  LIDHydrolase  16 eFYetFlsllseklnpelevlgishaGfeleeee...........keakenekvfsLedQiehkedflkellekaksekdvklilvGHSvGaYiale 101
                   +FY++F     e   ++++ + +   +++ + +e            ++++++++fs++ Q+++ e +  +     +++k + ++l G   Ga++al+
    EFC38133.1  83 DFYNQFSMIFDEG--KDFHFISVEIPSHCTTIDEfvpefdkfvnlVSNSSSNHIFSISPQLRFSEPISISN----SKSKSQCVHLCGCGLGAFLALN 173
                   6999998777777..8999999999999999999999999999988899999**********999875443....4579999*************** PP

  LIDHydrolase 102 vlkrlsersikkvvlLfPtiediakSpngkkltkllaylpflalvvglllrvlkllPesvkslliklvlgkssspkeavettlkfvkspevvrqalh 198
                    ++++ e+ +++++l+ +++     S+   +  +  + +p +     l  +v++++ ++  + ++++     s   e++   +  + s++ ++  l 
    EFC38133.1 174 YASEYVEK-VSSLILVNGFVNSTIFSEYSPLNDFY-VLAPKFL----LSTKVFDMFTHFKDREFMNNDEILYSI--EYMLDNVDKI-SQKQLASRLS 261
                   *******9.********999988888766555544.2222222....233334555555555555444433333..3444444555.3333444445 PP

  LIDHydrolase 199 lakdEmeeikeddeeedvllkknkeka.lvfyfgkkD..hWvpeetrdelkellg 250
                   l +dE + ++++d  e++++k+++++  ++++ + +D  +  p++ r el ++++
    EFC38133.1 262 LLSDE-RIVNTKDILEKLVIKSTQQNScITIIESMDDenSIYPSSLRTELQQKFP 315
                   55555.2333333334566666666655555544444113446666666666665 PP

>> Ndr  Ndr family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.2   1.1e-05     0.049     104     182 ..     162     238 ..      39     267 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.1e-05
                 EEETHHHHHHHHHHHHSGGGEEEEEEES---S---HHHHHHHHHH.......TTTS-HHHHHHHHHS-HHHHHHT-HHH CS
         Ndr 104 lGvgaGAyilarfalkhperveglvLinitskaagwvewakeKlsskllkkvgltdllkdlllahkFgkeeksensdlv 182
                  G g GA++ + +a ++ e+v++l+L+n   ++  + e+        l  k  l++ + d++   +F   e  +n ++ 
  EFC38133.1 162 CGCGLGAFLALNYASEYVEKVSSLILVNGFVNSTIFSEYSPLNDFYVLAPKFLLSTKVFDMFT--HFKDREFMNNDEIL 238
                 699*************************98888877777543322234445555555555543..45555555555555 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   4.1e-05      0.18      73     114 ..     154     195 ..     145     237 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 4.1e-05
  Hydrolase_4  73 hpelplfllGhSmGGliallyllrypdkvaglilsaPalkik 114
                  ++ + + l+G  +G+++al+y+ +y +kv+ lil++ +++  
   EFC38133.1 154 SKSQCVHLCGCGLGAFLALNYASEYVEKVSSLILVNGFVNST 195
                  55667889***************************9998755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (479 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 3182.05
//
Query:       EFC38134.1  [L=300]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0028   16.3   0.3       0.02   13.4   0.1    1.9  2  Utp8      Utp8 family
  ------ inclusion threshold ------
      0.021   14.9   0.2       0.81    9.8   0.0    2.8  3  NHL       NHL repeat
      0.047   13.6   0.8        7.9    6.6   0.0    3.1  3  PQQ       PQQ enzyme repeat


Domain annotation for each model (and alignments):
>> Utp8  Utp8 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.1     0.012        73     102     161 ..     153     210 ..     123     222 .. 0.75
   2 !   13.4   0.1   3.3e-06      0.02     115     204 ..     211     300 .]     204     300 .] 0.91

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.012
        Utp8 102 skLlliekekeeteddkteeetsseyevklkkkvvsikisskkkqivvvlenGsielldf 161
                  ++ +i  +++   +d+++ +  + +++ l++++v++ + ++++ iv      ++++++f
  EFC38134.1 153 TEIYVIDYAQKMFVYDSKTGKLRDDIQIDLDRQLVDLVFTPEEEMIV--CGVDQLHIMKF 210
                 467778778888999****************************9555..44444444444 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 3.3e-06
        Utp8 115 eddkteeetsseyevklkkkvvsikisskkkqivvvlenGsielldfelklleslksskknkklvetfiedeekelllvvskskkkvayk 204
                 + ++++ e+ ++ e ++ ++ +s+  ++k+++i++  +nG+i++ld + + l++++  ++ ++ +  +i+d++ el+l+ s  k+ ++yk
  EFC38134.1 211 NENSATWEKIKTLENTTPNRCFSVWYEKKTRLIYLTDANGKIYILDRQFNILKTVTELESLSSPYGIVINDKNGELFLCNSGTKEILIYK 300
                 5567788899999999***************************************99999999********9999999999999888887 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.1         3   1.8e+04      14      20 ..     154     160 ..     154     160 .. 0.82
   2 ?    2.0   0.0     0.042   2.5e+02      10      20 ..     247     257 ..     243     260 .. 0.81
   3 ?    9.8   0.0   0.00014      0.81       1      28 []     271     299 ..     271     299 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 3
                 EEEEEEC CS
         NHL  14 diyVaDs 20 
                 +iyV D+
  EFC38134.1 154 EIYVIDY 160
                 69**995 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.042
                 ETTTEEEEEEC CS
         NHL  10 dsnGdiyVaDs 20 
                 d nG iy+ D+
  EFC38134.1 247 DANGKIYILDR 257
                 389*****995 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00014
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 +++P G++++ +nG+++ ++s++  + ++
  EFC38134.1 271 LSSPYGIVINdKNGELFLCNSGTKEILIY 299
                 56789*****************9999876 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.9   1.1e+04      20      26 ..     132     138 ..     132     139 .. 0.84
   2 ?    4.3   0.0    0.0073        44       7      22 ..     159     174 ..     153     175 .. 0.81
   3 ?    6.6   0.0    0.0013       7.9       2      17 ..     242     257 ..     241     258 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.9
                 CCEEEEE CS
         PQQ  20 GkvlWrf 26 
                 G+ +W+ 
  EFC38134.1 132 GEPIWKA 138
                 899**96 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.0073
                 ETTSEEEEEETTTCCE CS
         PQQ   7 sadGylyAlDadTGkv 22 
                 ++  + + +D +TGk+
  EFC38134.1 159 DYAQKMFVYDSKTGKL 174
                 6778899*******97 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.0013
                 EEEEEETTSEEEEEET CS
         PQQ   2 vvylgsadGylyAlDa 17 
                  +yl++a+G++y lD+
  EFC38134.1 242 LIYLTDANGKIYILDR 257
                 59*************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       566  (0.031569); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 1813.46
//
Query:       EFC38135.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.4e-22   79.2   0.0    1.3e-21   77.3   0.0    2.0  2  PseudoU_synth_2  RNA pseudouridylate synthase


Domain annotation for each model (and alignments):
>> PseudoU_synth_2  RNA pseudouridylate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.22   3.9e+03     103     132 ..      70      99 ..      23     134 .. 0.56
   2 !   77.3   0.0   7.3e-26   1.3e-21       2     158 ..     164     342 ..     163     343 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.22
  PseudoU_synth_2 103 tekqegarrkaeeldgkkavtylkvlksgs 132
                      ++k ++ ++ ++ ++   + t  +vl+s+ 
       EFC38135.1  70 FVKPHKTNHRTNVRTRWFKKTTMEVLSSEF 99 
                      445555555555555555556666666554 PP

  == domain 2  score: 77.3 bits;  conditional E-value: 7.3e-26
  PseudoU_synth_2   2 lvvvnKPagvpvqpeakdgsekekettatssraeeekkelklvhRLDkatsGllllAksseaanklakafeerkvrKkYlalvfgapeeeegai 95 
                      ++v++KP+ +pv+p +     +  +++  +  ++   ++l l+hRLDk tsG+l+ + ++++a+  ++ ++e +vrK Yla v g+ +e+e+  
       EFC38135.1 164 FLVIDKPSSIPVHPAG-----RFVKNSLHYLLESALGRKLFLIHRLDKVTSGVLIHTWNAALAKSYQDTMKEGNVRKCYLAQVYGEFPETENMS 252
                      89**************.....888888899999999***********************************************94444444444 PP

  PseudoU_synth_2  96 kkkiskd...........................tekqegarrkaeeldgkkavtylkvlksgsseksakvslveleletGrkhQiRvhl 158
                       +++  +                           + ++++  + +   d k+++t +  +k+ +++  +  s v   ++tGr+hQiR hl
       EFC38135.1 253 GEHVLLNgqsfhkdkegfihvknkmvykqndwtfIWRADSSENGSDSTDPKNTDTAYTLVKRIYYDPASSRSIVIAIPITGRTHQIREHL 342
                      444433377777777777777777777788888888888999999999999999999999999999***********************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       689  (0.0384294); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 2764.19
//
Query:       EFC38136.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.2e-10   38.9  11.4    1.3e-09   38.3  11.4    1.3  1  zf-RING_2     Ring finger domain
    5.4e-07   29.8  11.0    1.4e-06   28.5  11.0    1.7  1  zf-rbx1       RING-H2 zinc finger domain
      2e-06   27.7  10.5    3.2e-06   27.0  10.5    1.3  1  zf-RING_5     zinc-RING finger domain
    2.3e-06   27.3  10.8      4e-06   26.6  10.8    1.4  1  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
    8.3e-06   25.7   8.0    1.6e-05   24.8   8.0    1.5  1  zf-RING_UBOX  RING-type zinc-finger
    7.1e-05   22.6  10.5    0.00015   21.5  10.5    1.6  1  zf-C3HC4_2    Zinc finger, C3HC4 type (RING finger)
    0.00016   21.3  11.0    0.00031   20.4  11.0    1.5  1  zf-RING_11    RING-like zinc finger
    0.00045   20.0   7.7     0.0016   18.2   7.8    1.8  2  Prok-RING_4   Prokaryotic RING finger family 4
    0.00083   19.2   8.3     0.0013   18.5   8.3    1.3  1  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
    0.00099   19.2   6.2     0.0021   18.1   6.2    1.6  1  zf-C3HC4_4    zinc finger of C3HC4-type, RING
     0.0021   18.1   6.1      0.014   15.5   6.1    2.0  1  zf-ANAPC11    Anaphase-promoting complex subunit 11 RING-H2 f
  ------ inclusion threshold ------
      0.028   14.2   6.3      0.054   13.3   6.3    1.5  1  zf-RING_4     RING/Ubox like zinc-binding domain
      0.038   14.2  10.3       0.27   11.5  10.3    2.1  1  FANCL_C       FANCL C-terminal domain
        0.1   12.8   4.9       0.21   11.8   4.9    1.5  1  zf-HC5HC2H_2  PHD-zinc-finger like domain
       0.17   12.2   7.6        0.4   11.0   7.6    1.6  1  zf-HC5HC2H    PHD-like zinc-binding domain
       0.32   10.6   9.2       0.63    9.7   9.2    1.5  1  Zn_ribbon_17  Zinc-ribbon, C4HC2 type
       0.87    9.8  10.5        1.5    9.0  10.5    1.4  1  RINGv         RING-variant domain
        1.8    8.9   8.9        1.1    9.6   0.3    2.4  2  zf-Di19       Drought induced 19 protein (Di19), zinc-binding
        5.3    7.4  10.1        9.9    6.6  10.1    1.5  1  zf-RING-like  RING-like domain


Domain annotation for each model (and alignments):
>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3  11.4   1.3e-12   1.3e-09       3      44 .]     192     236 ..     190     236 .. 0.87

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 1.3e-12
   zf-RING_2   3 CpICleelssads..vlllpCgHvfhreClerwlrssst.CPlCr 44 
                 C+IC e++s ++   +++l+CgH+fh +C+++w+rs s  CP+Cr
  EFC38136.1 192 CSICHENFSHQELkdCRKLECGHIFHLTCISQWMRSGSFtCPFCR 236
                 ********543335599999**************999989****9 PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5  11.0   1.4e-09   1.4e-06      12      55 .]     190     236 ..     185     236 .. 0.78

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 1.4e-09
     zf-rbx1  12 eacieckapgdee....cpvvlGeCgHaFHlhCiskWlkt.rkvCPlcr 55 
                 e c  c+++ +++    c +    CgH FHl Cis+W+++ + +CP cr
  EFC38136.1 190 ELCSICHENFSHQelkdCRKLE--CGHIFHLTCISQWMRSgSFTCPFCR 236
                 5566666665555555588776..****************8999****8 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0  10.5   3.3e-09   3.2e-06       2      44 .]     192     237 ..     191     237 .. 0.92

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 3.3e-09
   zf-RING_5   2 CnkCfekl..skeekfyltsCgHifCekClkkll.ekeavCpiCrk 44 
                 C++C+e++  ++ +++  ++CgHif+ +C+++ +   +++Cp+Cr+
  EFC38136.1 192 CSICHENFshQELKDCRKLECGHIFHLTCISQWMrSGSFTCPFCRR 237
                 ********7666666*****************************95 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.6  10.8   4.3e-09     4e-06       1      41 []     192     235 ..     192     235 .. 0.99

  Alignments for each domain:
  == domain 1  score: 26.6 bits;  conditional E-value: 4.3e-09
                 -TTT-S--SS-E.....E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepn....elleCkHsfCskCirkilksrkkvkCPlC 41 
                 C+iC e+++ +     + leC+H f+ +Ci+++++ +++++CP C
  EFC38136.1 192 CSICHENFSHQElkdcRKLECGHIFHLTCISQWMR-SGSFTCPFC 235
                 ***********99**********************.********* PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   8.0   1.7e-08   1.6e-05       1      39 []     192     233 ..     192     233 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 1.7e-08
  zf-RING_UBOX   1 CpIClelftdP.....lvlpCGHtFCreClwelskslegafkCP 39 
                   C+IC e f++       +l+CGH+F+  C+  ++  ++g+f+CP
    EFC38136.1 192 CSICHENFSHQelkdcRKLECGHIFHLTCI--SQWMRSGSFTCP 233
                   *********44444543369**********..78899******9 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5  10.5   1.6e-07   0.00015       2      40 .]     192     235 ..     191     235 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 1.6e-07
  zf-C3HC4_2   2 CpiCldmlkdpsvvt.....pCgHvfCqkCilrsLeekn.eCPlC 40 
                 C iC + ++    ++     +CgH f+  Ci +++++++  CP C
  EFC38136.1 192 CSICHENFSHQ-ELKdcrklECGHIFHLTCISQWMRSGSfTCPFC 235
                 99999877664.444455569************************ PP

>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4  11.0   3.3e-07   0.00031       2      29 .]     192     221 ..     192     221 .. 0.93

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 3.3e-07
  zf-RING_11   2 CsICLeefkpgq..alfilpCsHtFHfkCI 29 
                 CsIC e+f + +    + l+C+H+FH+ CI
  EFC38136.1 192 CSICHENFSHQElkDCRKLECGHIFHLTCI 221
                 *********8777788999**********9 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.2      0.59   5.6e+02      32      43 ..     191     202 ..     186     203 .. 0.73
   2 !   18.2   7.8   1.7e-06    0.0016       1      40 [.     192     239 ..     192     243 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.59
  Prok-RING_4  32 sCPlCqrrisks 43 
                   C +C++++s++
   EFC38136.1 191 LCSICHENFSHQ 202
                  588999888765 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 1.7e-06
  Prok-RING_4   1 CvlCgeq.....ekkailepCgHlvCkeCfdskdls...sCPlCqrri 40 
                  C +C e+      k+ +   CgH++  +C +++  s   +CP+C+r++
   EFC38136.1 192 CSICHENfshqeLKDCRKLECGHIFHLTCISQWMRSgsfTCPFCRRQL 239
                  889999866666566666779************888889*******97 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   8.3   1.4e-06    0.0013       2      46 ..     189     238 ..     188     241 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.4e-06
                 GSB-TTTSSS.....BS-EEETTEEEEEE-HHHHHHHHH.TT-B-TTT--B CS
  zf-C3HC4_3   2 deeCviCler.....prnvvllpCgHlvlCeeCaekllk.rkkkCpiCrrp 46 
                 +e+C+iC+e+      +++  l+CgH+ +  +C +++++  + +Cp+Crr+
  EFC38136.1 189 QELCSICHENfshqeLKDCRKLECGHI-FHLTCISQWMRsGSFTCPFCRRQ 238
                 689******5444448999999*****.*********999*********97 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   6.2   2.3e-06    0.0021       8      42 .]     204     235 ..     192     235 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 2.3e-06
  zf-C3HC4_4   8 LekPvsleCGhsfClsCisslqkepdgeqllCplC 42 
                 L++   leCGh+f l+Cis+++ +    +++Cp+C
  EFC38136.1 204 LKDCRKLECGHIFHLTCISQWMRSG---SFTCPFC 235
                 466778*************998876...59***** PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   6.1   1.4e-05     0.014      18      81 ..     186     239 ..     179     241 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.4e-05
                 -SSSSB-TTT-SBTTS--TTCSTTTTTS-EEEBTTS-EEEHHHHHHHHHHHSTSSB-TTTSSB- CS
  zf-ANAPC11  18 vasddvcGicrvsfdGtcpsckfpGddcplvlGkckhnfhlhcilkwletetskglcpmcrqtf 81 
                 ++++++c ic  +f            dc  +  +c h+fhl ci +w+ +      cp+cr+++
  EFC38136.1 186 ITHQELCSICHENFSHQ------ELKDCRKL--ECGHIFHLTCISQWMRSG--SFTCPFCRRQL 239
                 55566666666666432......22355443..7*************9865..468****9865 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   6.3   5.7e-05     0.054       1      46 [.     192     238 ..     190     239 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.7e-05
   zf-RING_4   1 cplCdeeldetdkdlkpC...eCgyqiClfCyhrileeeegrCPaCree 46 
                 c +C e+++   ++lk C   eCg+ + l C ++ +++ ++ CP Cr++
  EFC38136.1 192 CSICHENFSH--QELKDCrklECGHIFHLTCISQWMRSGSFTCPFCRRQ 238
                 8899999954..4455555559*************************86 PP

>> FANCL_C  FANCL C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5  10.3   0.00028      0.27       4      44 ..     191     228 ..     188     241 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00028
                 S-SSS--SS-TT-----B--S-TT----B-SGGGHHHHHHH CS
     FANCL_C   4 eCgiCyayrldsgevpdisCdnekCnkkfHsaCLkeWlrsl 44 
                  C+iC  ++    +   + C   +C+++fH +C+ +W+rs 
  EFC38136.1 191 LCSICHENFS---HQELKDCRKLECGHIFHLTCISQWMRSG 228
                 6****99988...445677*******************985 PP

>> zf-HC5HC2H_2  PHD-zinc-finger like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   4.9   0.00022      0.21      53      87 ..     187     223 ..     173     236 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00022
  zf-HC5HC2H_2  53 rlkekCllCkkr..kGaciqCskkeCktafHvtCala 87 
                   + +e C++C+++  +     C k eC ++fH tC+++
    EFC38136.1 187 THQELCSICHENfsHQELKDCRKLECGHIFHLTCISQ 223
                   35689******986666678**************976 PP

>> zf-HC5HC2H  PHD-like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   7.6   0.00042       0.4      34      68 ..     187     223 ..     175     238 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00042
  zf-HC5HC2H  34 rkklkCylCkkk..vGaciqCskkkCkkafHvtCake 68 
                 + +  C++C+++  +     C+k +C + fH+tC  +
  EFC38136.1 187 THQELCSICHENfsHQELKDCRKLECGHIFHLTCISQ 223
                 56788*****9966668899**************876 PP

>> Zn_ribbon_17  Zinc-ribbon, C4HC2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   9.2   0.00067      0.63       5      46 ..     190     233 ..     186     236 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00067
  Zn_ribbon_17   5 ksCayCelav.kgrvvlcg..vCeHvlHasCarewfenddlaeCp 46 
                   + C++C+ +  ++ +  c   +C+H+ H  C+++w   +    Cp
    EFC38136.1 190 ELCSICHENFsHQELKDCRklECGHIFHLTCISQWMRSGS-FTCP 233
                   6688887765245566775226**************9999.7887 PP

>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0  10.5    0.0016       1.5       1      48 []     192     235 ..     192     235 .. 0.92

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0016
                 ETTTTEE-SSSS--B-SS--STCCCSB-HHHHHHHHHHTCT-SB-TTT CS
       RINGv   1 CriCleeeeeseplispCkCrGslklvHesClekWldekeantqCeiC 48 
                 C iC+e+ +++e   + C+     +++H +C+++W+++   + +C +C
  EFC38136.1 192 CSICHENFSHQE--LKDCRKLECGHIFHLTCISQWMRS--GSFTCPFC 235
                 9******99988..88999888889***********99..99999999 PP

>> zf-Di19  Drought induced 19 protein (Di19), zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   3.5      0.24   2.3e+02      25      44 ..     183     202 ..     174     220 .. 0.78
   2 ?    9.6   0.3    0.0012       1.1       2      12 ..     229     239 ..     228     242 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.24
     zf-Di19  25 HrveskevvCPvCaekvtkd 44 
                 H + +++  C++C e+ +++
  EFC38136.1 183 HEEITHQELCSICHENFSHQ 202
                 88889999*****9887653 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0012
     zf-Di19   2 sftCPyCgkel 12 
                 sftCP+C+++l
  EFC38136.1 229 SFTCPFCRRQL 239
                 7******9865 PP

>> zf-RING-like  RING-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6  10.1      0.01       9.9       1      43 []     192     235 ..     192     235 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.01
  zf-RING-like   1 CeaCkeivtqGvr..CsnesCnvrlHvdCfqhyirthsskkCpkC 43 
                   C++C+e   +  +  C + +C  ++H  C+ + + ++ s +Cp C
    EFC38136.1 192 CSICHENFSHQELkdCRKLECGHIFHLTCISQWM-RSGSFTCPFC 235
                   777777666554333*****************99.77888***99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       912  (0.0508673); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.43u 0.22s 00:00:00.65 Elapsed: 00:00:00.42
# Mc/sec: 2467.26
//
Query:       EFC38137.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.5e-61  206.9   0.0    4.9e-61  206.4   0.0    1.2  1  Pkinase         Protein kinase domain
    1.5e-37  129.3   0.0      2e-37  128.9   0.0    1.1  1  Pkinase_Tyr     Protein tyrosine kinase
    6.5e-06   25.7   0.1    0.00024   20.5   0.1    2.7  2  Kinase-like     Kinase-like
     0.0026   16.8   1.2     0.0085   15.1   0.0    2.3  2  Haspin_kinase   Haspin like kinase domain
     0.0031   17.5   0.0     0.0079   16.1   0.0    1.7  2  APH             Phosphotransferase enzyme family
     0.0054   15.6   0.0     0.0089   14.9   0.0    1.3  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.011   15.1   0.0      0.027   13.8   0.0    1.6  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
      0.017   14.7   1.6        0.9    9.1   0.0    2.3  2  Choline_kinase  Choline/ethanolamine kinase
      0.052   13.2   0.0      0.092   12.3   0.0    1.4  1  RIO1            RIO1 family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  206.4   0.0   2.4e-64   4.9e-61       2     264 .]      40     296 ..      39     296 .. 0.89

  Alignments for each domain:
  == domain 1  score: 206.4 bits;  conditional E-value: 2.4e-64
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH.HHSS--HHH CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle.rkgslseee 99 
                 e+l+ lG+Gs+G+Vy + +k++g+  A+K i++ +++k+k  ++++E++ l + ++++++ ++++f+++ ++ + ley+egg+l d+++  +g ++e+ 
  EFC38137.1  40 ETLHMLGKGSSGNVYLVSHKASGQFLALKYISVFDDQKRK--TIINELQTLYTASSEFLIGFFGAFYQEGNIQIALEYMEGGSLSDIIKtVQGPIQEKF 136
                 56789***************************99888866..6**********************************************76788***** PP

                 HHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-S CS
     Pkinase 100 akkiakqilegleylH.skgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkpp 196
                 + +i++q++ gl+ylH +++++HrDlKp NiL+++kg++Ki+DFG+++el+++     sfvgt +Y+    l++++ys ++D+W+lG+i++e +tgk p
  EFC38137.1 137 LARIIQQVCLGLKYLHkERHLVHRDLKPGNILFNTKGQFKISDFGVSAELDNTGAeCGSFVGTVTYM---RLEGKKYSFASDIWALGIIVLESVTGKFP 232
                 ****************5556******************************9998779**********...799************************** PP

                 TTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 197 fsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 f+  ++++++   + +l +++k  +++  ++ ++   s+++ d++  +l+kdpk+R t+++ll+hp++
  EFC38137.1 233 FR--DEQDEAIGVFWELLNTIK--TKEPPSISTNMGYSKDVCDFIALCLQKDPKQRATVSDLLEHPFI 296
                 **..333333444444333333..3444666666677*****************************97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.9   0.0     1e-40     2e-37       2     257 ..      40     292 ..      39     293 .. 0.89

  Alignments for each domain:
  == domain 1  score: 128.9 bits;  conditional E-value: 1e-40
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekek 99 
                  e+ + lG+G+ G+V+  + k     + +  a+K ++   ++++++ +++e++++ + + + ++ + g+ ++e+++ i +ey++gG+L++ +++  + +
   EFC38137.1  40 ETLHMLGKGSSGNVYLVSHK----ASGQFLALKYISV-FDDQKRKTIINELQTLYTASSEFLIGFFGAFYQEGNIQIALEYMEGGSLSDIIKTV-QGP 131
                  66789**********99988....888999*****55.556669*************************************************9.*** PP

                  SBHHHHHHHHHHHHHHHHHHHH.TTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHH CS
  Pkinase_Tyr 100 ltlkdllsfalqvAkGmeyLes.kklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllw 196
                  ++ k l ++++qv+ G++yL++ ++lvHrdl   N+L +++ + kisDfG++ ++  d++  + ++    v +m +E    kk++ +sD+W+ G+++ 
   EFC38137.1 132 IQEKFLARIIQQVCLGLKYLHKeRHLVHRDLKPGNILFNTKGQFKISDFGVSAEL--DNTGAECGSFVGTVTYMRLE---GKKYSFASDIWALGIIVL 224
                  ********************97267******************************..6666788888999****877...699*************** PP

                  HHHTTSSGTTTTSHHHH......HHHHHHTTEE..S-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 197 Eiftlgespypglknee......vleklkegkr..lekpekcpeelyelmkkcweedpeeRptfselve 257
                  E +t g+ p+++ ++e       +l+++k+++   ++++   ++++ +++  c+++dp++R+t s+l+e
   EFC38137.1 225 ESVT-GKFPFRDEQDEAigvfweLLNTIKTKEPpsISTNMGYSKDVCDFIALCLQKDPKQRATVSDLLE 292
                  ****.******9988876655556777755554225666777999********************9976 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0     0.096   1.9e+02      15      56 ..      40      81 ..      29      93 .. 0.84
   2 !   20.5   0.1   1.2e-07   0.00024     159     261 ..     150     244 ..     121     279 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.096
  Kinase-like 15 vrgellkkgdrsvvfevkdqetgeplavkvfllpseaskkdl 56
                    ++l+kg ++ v++v  ++ g+ la+k  ++ ++  +k++
   EFC38137.1 40 ETLHMLGKGSSGNVYLVSHKASGQFLALKYISVFDDQKRKTI 81
                 5567899**********************9999998888876 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 1.2e-07
  Kinase-like 159 nLq.akglvhgkftvdnllldekgglmlggftaLvragtkvvlsevekgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwclklPltlate 255
                  +L+ ++ lvh ++++ n+l++ kg++++ +f+      + +         +   ++g   +y r +  k++++ d W+lG+ ++     k P+   ++
   EFC38137.1 150 YLHkERHLVHRDLKPGNILFNTKGQFKISDFGVSAELDNTGA--------ECGSFVGT-VTYMRLEGKKYSFASDIWALGIIVLESVTGKFPFRDEQD 238
                  5651468************************86555444444........45566776.779999999*************************98888 PP

  Kinase-like 256 eakeew 261
                  ea+  +
   EFC38137.1 239 EAIGVF 244
                  877654 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   4.3e-06    0.0085     175     255 ..      79     184 ..       4     212 .. 0.68
   2 ?   -2.1   0.2      0.69   1.4e+03      64      88 ..     317     342 ..     293     349 .. 0.54

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 4.3e-06
  Haspin_kinase 175 k.....................pdfyseqqlflvlllkdkGtdLeev.....klkswkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdknl 244
                    k                       fy+e+++ + l+  ++G+ L+ +        + k   +i  q+   L+   ++ ++ HRdL+ +niL + ++
     EFC38137.1  79 KtiinelqtlytassefligffGAFYQEGNIQIALEYMEGGS-LSDIiktvqGPIQEKFLARIIQQVCLGLKYLHKERHLVHRDLKPGNILFNTKG 173
                    033333344444444666666688999999999999888775.4443321222234566789********************************** PP

  Haspin_kinase 245 nvtlidlklsR 255
                    +  + d+ +s 
     EFC38137.1 174 QFKISDFGVSA 184
                    ******98874 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.69
  Haspin_kinase  64 sesllslnsqeev.kdfdevilsqil 88 
                     ++l+ + sq+e   + d++i++q l
     EFC38137.1 317 INQLVKIRSQTEKsAQLDQNIKTQSL 342
                    33444444444444455555555544 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0         2   3.9e+03       2      24 ..      42      65 ..      41      71 .. 0.84
   2 !   16.1   0.0     4e-06    0.0079     160     187 ..     151     175 ..     113     182 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2
                EEEE--.SSCEEEEEEETT.--EE CS
         APH  2 vrelsggasnrtylvttpa.gryv 24
                ++ l+ g s  +ylv ++a g+++
  EFC38137.1 42 LHMLGKGSSGNVYLVSHKAsGQFL 65
                67899999*9******99988775 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 4e-06
                 --SSS-EEEE-SS-SGGGEEEC..TTEE CS
         APH 160 lpgelptvllHgDlhpgNllvdpddgrv 187
                 l  + ++ l+H+Dl+pgN+l++ ++g++
  EFC38137.1 151 L--HKERHLVHRDLKPGNILFN-TKGQF 175
                 2..68999**************.66664 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   4.4e-06    0.0089     311     384 ..     140     206 ..     123     217 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 4.4e-06
  Pkinase_fungal 311 alrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaie 384
                      ++++  g++ L+++  ++HrD   +Nil++      + +  ++D+ +  el++  + ++ +  +GT+ +m +e
      EFC38137.1 140 IIQQVCLGLKYLHKERHLVHRDLKPGNILFN-----TKGQFKISDFGVSAELDN--TGAECGSFVGTVTYMRLE 206
                     56778899***********************.....566778999999999995..555667899***999876 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   1.4e-05     0.027     104     161 ..     120     177 ..     108     186 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.4e-05
         Kdo 104 dLedllakwae.laeelkrallkavgrliaklhr.agvnHadlyaknillqqeeeeeaei 161
                 +L d++++ +  ++e+  ++++++v    + lh+ +++ H+dl + nil+++++  +++i
  EFC38137.1 120 SLSDIIKTVQGpIQEKFLARIIQQVCLGLKYLHKeRHLVHRDLKPGNILFNTKG--QFKI 177
                 7888888866688999999**************73689**************98..5544 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.0   0.00045       0.9     131     171 ..     141     180 ..      83     189 .. 0.83
   2 ?    4.3   0.8     0.013        26      87     133 ..     303     348 ..     279     350 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00045
                     HHTHHHHHHCHGG-EEEE-S--SGGGEEE.-CTTEEEE--G CS
  Choline_kinase 131 lekleklleelespvvfcHnDlqegNillnkeekklvlIDF 171
                     ++++   l++l+++  + H Dl +gNil+ +++++  + DF
      EFC38137.1 141 IQQVCLGLKYLHKERHLVHRDLKPGNILF-NTKGQFKISDF 180
                     444444445778888999***********.99999999998 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.013
                     SSSS-HHHHHHHHHHHCCS.TT..ECHHGGCCHCCCTHHHHHHHHHT CS
  Choline_kinase  87 skespslwktmqkwllnkeaqtkakkekkkkqlklinledlekelek 133
                     +  s s w++ ++w +n+ +++ +++ek+ +  + i++++le++l+ 
      EFC38137.1 303 TPTSASEWQQYNNW-INQLVKIRSQTEKSAQLDQNIKTQSLENKLKA 348
                     5567788*******.99999999999999999999999999998875 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   4.6e-05     0.092     106     160 ..     136     191 ..     111     193 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.6e-05
                 HHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETT.EEEE--GTTEEETTSTTH CS
        RIO1 106 eaeelyeevleemrklykeaglvHaDLSeyNvlvded.kvviIDvsQaveldhpna 160
                  ++++ ++v   ++ l ke +lvH DL   N+l++++ ++ i D++ + eld+  a
  EFC38137.1 136 FLARIIQQVCLGLKYLHKERHLVHRDLKPGNILFNTKgQFKISDFGVSAELDNTGA 191
                 345566666667889999***************99887999999999888887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       624  (0.0348039); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2290.29
//
Query:       EFC38138.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       721  (0.0402142); expected 358.6 (0.02)
Passed bias filter:                      275  (0.0153383); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 3126.33
//
Query:       EFC38139.1  [L=592]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-26   94.0   0.9    3.2e-25   89.3   0.2    2.6  2  RNA_lig_T4_1  RNA ligase
  ------ inclusion threshold ------
      0.038   13.9   0.6       0.11   12.4   0.6    1.8  1  GnsAB_toxin   GnsA/GnsB toxin of bacterial toxin-antitoxin sy


Domain annotation for each model (and alignments):
>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       1.1   9.6e+03     196     211 ..      31      44 ..      19      49 .. 0.68
   2 !   89.3   0.2   3.6e-29   3.2e-25       1     220 []      87     384 ..      87     384 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 1.1
  RNA_lig_T4_1 196 iEGfVvrckskkdffF 211
                   + GfV++ ++  df F
    EFC38139.1  31 TRGFVIQSNN--DFTF 44 
                   5699999988..4555 PP

  == domain 2  score: 89.3 bits;  conditional E-value: 3.6e-29
  RNA_lig_T4_1   1 eaRGLfteenkeerIvvRgydKFFNinEveetkweeieqkt.........qgpyelteKenGclilis.........alsdgklvvaSkhsl..... 74 
                   e RGL++++++ +rIv R++ KFFN++E+eet+++ ie+           ++p++l+eK +G+l +++         +++  +l + +k +      
    EFC38139.1  87 EIRGLCFDRES-RRIVGRSMPKFFNVDEKEETNFKIIEKLIselkkktgkERPFTLLEKLDGSLCTPIieflkddsgEKKHFRLRFRTKLDYqndhs 182
                   57*********.7*********************88887778899999*99****************999999995444444556666666699999 PP

  RNA_lig_T4_1  75 ...............................................................eaeshaevgerllekklekegkte..eeLaeell 106
                                                                                  +     + g + le++l+++g ++   +++ e++
    EFC38139.1 183 qsieefvyeleklnlvkgqssdvseqdeinreyhekrkklhesklplfaiesvkdgrecestrDIPFVIDFGMHSLEDQLKDKGSYAqlVKFCVEWM 279
                   9999999999999999999999999999999999999999999999999999999998887653344578888889999988888766679999*** PP

  RNA_lig_T4_1 107 eknlTavfElcddsfeehivaypeekagLyLhglnentp.efstesseevakfakefg......fiktklitlesleevkkfleevaetgswegeei 196
                   ++++T++fE+ ++  ++++v  + +k+ + L++l+++    f  ++  e+++ +k +g      + + ++i  ++++ +kk +e  +e+g       
    EFC38139.1 280 NRGYTPLFEYFSP--DHRVVVNYGNKPFISLLALRHTILgSFIPYE--EMKSSCKGYGiecvksCENPEIISQTDMKGIKKAIE--DEKG------H 364
                   *************..99999999************99888898888..**********75544333344444555555555555..4444......5 PP

  RNA_lig_T4_1 197 EGfVvrckskkdffFklKfkepyy 220
                   EG+V+ +++     +++K+k+++y
    EFC38139.1 365 EGYVMVLSN-G---YMYKIKSDWY 384
                   *******77.4...89*******9 PP

>> GnsAB_toxin  GnsA/GnsB toxin of bacterial toxin-antitoxin system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.6   1.3e-05      0.11      16      32 ..     120     136 ..     110     148 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.3e-05
                  HHHHHHHHHHHHHHSSE CS
  GnsAB_toxin  16 eliakKiaELkKkTGkE 32 
                  + i k i ELkKkTGkE
   EFC38139.1 120 KIIEKLISELKKKTGKE 136
                  579999**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (592 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       917  (0.0511462); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 3511.63
//
Query:       EFC38140.1  [L=666]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
        0.1   12.5   0.0       0.25   11.3   0.0    1.6  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   1.4e-05      0.25       8      35 ..     241     269 ..     239     273 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.4e-05
  F-box-like   8 iLlqIFsyLppsdLlr.lalVCrrWrrva 35 
                 +L+ IF++++  +L++ +a V+ ++++++
  EFC38140.1 241 VLCSIFEFIDSVELINvVASVSPQFHELI 269
                 9********999****66********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (666 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       872  (0.0486363); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 3855.99
//
Query:       EFC38141.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.8e-16   60.2   1.5    4.1e-16   59.1   1.5    1.6  1  DUF1771       Domain of unknown function (DUF1771)
      1e-09   38.1   0.0    1.9e-09   37.2   0.0    1.5  1  KH_1          KH domain
    9.4e-09   35.5   0.0    2.4e-08   34.2   0.0    1.7  2  Smr           Smr domain
  ------ inclusion threshold ------
      0.022   14.6   0.1      0.099   12.5   0.0    2.2  2  KH_2          KH domain
      0.068   13.4  10.9       0.11   12.7  10.9    1.4  1  AJAP1_PANP_C  AJAP1/PANP C-terminus
       0.13   12.2   0.3       0.49   10.4   0.0    2.1  2  DUF4250       Domain of unknown function (DUF4250)
       0.26   11.5   0.1       0.26   11.5   0.1    1.8  2  DUF2379       Protein of unknown function (DUF2379)


Domain annotation for each model (and alignments):
>> DUF1771  Domain of unknown function (DUF1771)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.1   1.5   1.6e-19   4.1e-16       4      64 .]     207     267 ..     204     267 .. 0.93

  Alignments for each domain:
  == domain 1  score: 59.1 bits;  conditional E-value: 1.6e-19
     DUF1771   4 lRaeAdeharkrnelfekAaeAyrrGdgaaAkelseqGkehgekmeeanreAaeaIfeerN 64 
                 l ++  e+ ++++ +fe+A++Ay++Gdg+  k+lse+Gk+h+e m+++ +e+a+ +fe+ N
  EFC38141.1 207 LEKKISEESKLMSDCFERAKKAYESGDGGLSKQLSEEGKQHQELMKKYQQESANTMFEHLN 267
                 556778999*************************************************977 PP

>> KH_1  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.2   0.0   7.3e-13   1.9e-09       7      64 ..     122     175 ..     116     177 .. 0.79

  Alignments for each domain:
  == domain 1  score: 37.2 bits;  conditional E-value: 7.3e-13
                 GGGHHHHHHTGGGHHHHHHHHHHT-EEEEESSTT...T.-EEEEEESHHHHHHHHHHH CS
        KH_1   7 PsslvgriIGkgGsnIkeIreetgakIkvpksedegsderevtisGspeavekAkeli 64 
                 P+  + +iIG++Gs+Ik+++eet  +I+v + +d+  d++ +ti  s++  +++ ++i
  EFC38141.1 122 PAVIAKFIIGPKGSTIKQLQEETSSRINVKD-SDD--DSKHITIEQSAN-PKACYDRI 175
                 5566889*********************995.443..89*****76665.55666666 PP

>> Smr  Smr domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       4.4   1.1e+04      44      70 ..     245     271 ..     232     272 .. 0.56
   2 !   34.2   0.0   9.5e-12   2.4e-08       1      56 [.     275     332 ..     275     346 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 4.4
                 HHHHHHHHHHHCSTTEEEEEE--CCCT CS
         Smr  44 vLrpavmgwLagkeaveafreaekkeG 70 
                 +  +++m+  ++++a   f++ +k++G
  EFC38141.1 245 KQHQELMKKYQQESANTMFEHLNKDKG 271
                 444555665666666665666555555 PP

  == domain 2  score: 34.2 bits;  conditional E-value: 9.5e-12
                 EE-TT--HHHHHHHHHHHHHHHHHTT-SEEEEE--STTSTT..HCHHHHHHHHHHHCS CS
         Smr   1 lDLhglrraealnvletfldaasakglrsvevihGkGahag..vgvLrpavmgwLagk 56 
                 +DLhg  ++ a++ l++ +++ + ++  ++++i G G+h++   ++++pav ++L+++
  EFC38141.1 275 IDLHGQYVDNAMDFLKKRIEKLRGEKQPKLTIIYGAGNHSDekGPKIKPAVLEYLKNE 332
                 8**************************************66679************98 PP

>> KH_2  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   3.9e-05     0.099      38      62 ..     128     151 ..     125     169 .. 0.86
   2 ?   -3.3   0.0       3.2   8.1e+03      54      63 ..     289     298 ..     279     306 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.9e-05
                 HHHTGGGHHHHHHHHHHHHHHHHHH CS
        KH_2  38 ivIGkgGsnikkigkelrkdiekle 62 
                  +IG +Gs+ik++++e   +i  ++
  EFC38141.1 128 FIIGPKGSTIKQLQEETSSRIN-VK 151
                 69****************9995.44 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.2
                 HHHHHHHHHT CS
        KH_2  54 lrkdiekleg 63 
                 l+k+iekl+g
  EFC38141.1 289 LKKRIEKLRG 298
                 5566666655 PP

>> AJAP1_PANP_C  AJAP1/PANP C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7  10.9   4.4e-05      0.11      12      99 ..      26     120 ..       7     161 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.4e-05
  AJAP1_PANP_C  12 vddesktvpnitlstkasrtttvatttstttrltqrtltvvttp........eprrlsttessvsegk.tvkppkilgdtsGlavhqiititvslim 99 
                   + +e+k++p +t+++++s++t + t+++ttt+++++  ++v +p         ++ + tt+  v+e+k  ++ppk +++t+ +a  +    t s+++
    EFC38141.1  26 L-EETKKEPATTTAATTSTSTST-TAAATTTTKASEQPAIVEEPtkkpevtkPAEPIKTTDVVVEEKKaVAEPPKATTTTPSVAASNFDEATNSFVL 120
                   2.455556666655555533322.2222333333333344444477888885455689999999988734689999999999999888888887775 PP

>> DUF4250  Domain of unknown function (DUF4250)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   0.00019      0.49      35      55 .]     173     193 ..     168     193 .. 0.93
   2 ?   -2.0   0.1       1.4   3.7e+03      21      41 ..     257     277 ..     247     279 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00019
     DUF4250  35 eeleekLasigYeYdeeqnqF 55 
                 + ++++L++ g+e+d+++nqF
  EFC38141.1 173 DRIMAELKKYGWEFDAKENQF 193
                 57999***************9 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.4
     DUF4250  21 ssldelcedldidkeeleekL 41 
                 +s + ++e+l+ dk +le  L
  EFC38141.1 257 ESANTMFEHLNKDKGDLEIDL 277
                 677888888998988887655 PP

>> DUF2379  Protein of unknown function (DUF2379)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.9       6.2   1.6e+04      34      55 ..      28      49 ..      19      59 .. 0.45
   2 ?   11.5   0.1    0.0001      0.26      48      90 ..     192     234 ..     186     260 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 6.2
     DUF2379 34 rtarevaiseadaeeaLatees 55
                 t +e a ++a ++++  ++++
  EFC38141.1 28 ETKKEPATTTAATTSTSTSTTA 49
                4444444443333333222222 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.0001
     DUF2379  48 eaLateesAlaLlreiarRiregskrLvdallrmlrlrdagDl 90 
                 + ++ +++A+++ +e +++i+e sk ++d   r+++  ++gD 
  EFC38141.1 192 QFVEHDTDAMKMFKELEKKISEESKLMSDCFERAKKAYESGDG 234
                 5578899**********************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2340  (0.130515); expected 358.6 (0.02)
Passed bias filter:                      638  (0.0355848); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.84u 0.37s 00:00:01.21 Elapsed: 00:00:00.53
# Mc/sec: 1985.82
//
Query:       EFC38142.1  [L=587]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.2e-58  196.6  30.8    6.3e-58  196.3  26.6    2.0  2  MIG-14_Wnt-bd  Wnt-binding factor required for Wnt secretion
  ------ inclusion threshold ------
      0.022   15.0   4.8       0.69   10.2   0.0    3.3  4  DUF3382        Domain of unknown function (DUF3382)
      0.065   12.8   0.2        1.6    8.2   0.2    2.6  2  DUF2140        Uncharacterized protein conserved in bacteria 
       0.95    9.8   6.0       0.54   10.6   1.2    3.0  3  FtsH_ext       FtsH Extracellular


Domain annotation for each model (and alignments):
>> MIG-14_Wnt-bd  Wnt-binding factor required for Wnt secretion
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1     0.017        74     158     192 ..      19      53 ..       2      76 .. 0.48
   2 !  196.3  26.6   1.4e-61   6.3e-58       2     290 ..     244     533 ..     243     535 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.017
  MIG-14_Wnt-bd 158 pklllvlllwlvllvlalyerleqlkdpfysiwss 192
                    p+ +++l+l lvll++ l+  +  + +p  s+  +
     EFC38142.1  19 PRWSVILILVLVLLIVGLFVIISLFASPEASVTVT 53 
                    44444444444444444444444444444433333 PP

  == domain 2  score: 196.3 bits;  conditional E-value: 1.4e-61
  MIG-14_Wnt-bd   2 CdeitlfelgsldystYlinvrfpnl.ksdnlsikekdlefelitinpgftlfeisfrtvfliisliililfl.fslrklsfrdwtleqkwilvLl 95 
                    C+ itlf+ + ++ys+Y +n+++ nl +  ++++ e+ +e +l++ np+++++e++fr++f ++s++ +i fl +++ +++ r+w++ qkw++vLl
     EFC38142.1 244 CSAITLFHSRVIRYSNYKMNLTILNLeNVYRSGLLENAIETSLQSNNPQYSMYELGFRMTFSVLSILHWIAFLvVTFWSQQLRNWHTAQKWLVVLL 339
                    **************************766667778889***********************************66666****************** PP

  MIG-14_Wnt-bd  96 illilfNnPffilellfnswflllldiifqsiFlsvLllFwlvffeslrdeqnrrktlsfylpklllvlllwlvllvlalyerleqlkdpfysiws 191
                    +l +++ +P++++++++ ++ ++++dii  ++F+  +ll++l+ff+s+ + +++r++++fyl k+++v+++++++l+l+++ r++++ +p     s
     EFC38142.1 340 FLHFWYHDPLYPAMMWTGWEGFPVVDIILSVTFVYGFLLYLLIFFHSVFKAPQDRTFMNFYLTKIIIVGIGYILTLILMIWSRVYNVANPSSVDIS 435
                    ******************************************************************************************998877 PP

  MIG-14_Wnt-bd 192 s...alilkilaiilavlyflyLlylifrsfseirskrvkegdiRfkflilltllvlavlvifiilglvse.lsptsdssaqflgvygllNlyvyt 283
                    s   + +l +  i+++vl+ + L y+ifr++ ++ + ++ +++ Rf++   + ++ ++v+++fi l+++++ +  t  +s+ fl+++g++ +y+  
     EFC38142.1 436 SvpgYAYLLAANIVFLVLWGIDLAYYIFRAMGAVGKLKA-KYSSRFRV---VGSFSFIVAACFIGLTIAGNgF-RTDVQSLTFLLLHGIVYVYFAS 526
                    788755999***************************665.5567****...7777777777777777766645.45556***************** PP

  MIG-14_Wnt-bd 284 laylYaP 290
                    l +l +P
     EFC38142.1 527 LSFLLMP 533
                    ****999 PP

>> DUF3382  Domain of unknown function (DUF3382)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.0    0.0061        27      31      70 ..      12      55 ..       3      75 .. 0.65
   2 ?   -1.6   0.3      0.74   3.3e+03      74      90 ..     324     339 ..     299     342 .. 0.57
   3 ?   -2.8   0.1       1.7   7.8e+03      81      97 .]     438     454 ..     405     454 .. 0.61
   4 ?   10.2   0.0   0.00015      0.69      13      74 ..     487     548 ..     482     564 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0061
     DUF3382 31 rlvlep..rwglvaiavavvfvgqLlr..plllqalkarkklkk 70
                ++vl    rw  ++i+v+v  ++ L++  +l++++ +++  +++
  EFC38142.1 12 EFVLDClpRWSVILILVLVLLIVGLFViiSLFASPEASVTVTRR 55
                555554449*****999999999887522455555555444444 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.74
     DUF3382  74 kadgvlvltqrwiilll 90 
                 ++++ ++  q+w+++ll
  EFC38142.1 324 QLRNWHT-AQKWLVVLL 339
                 2233333.555655555 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 1.7
     DUF3382  81 ltqrwiillllvvAlvw 97 
                   + +++ + +v+ ++w
  EFC38142.1 438 PGYAYLLAANIVFLVLW 454
                 36667777777777777 PP

  == domain 4  score: 10.2 bits;  conditional E-value: 0.00015
     DUF3382  13 alvlfvpilGlqleldgtrlvleprwglvaiavavvfvgqLlrplllqalkarkklkkvesk 74 
                  +++++ ++Gl+++ +g r+ +++   l++ +++ v + +L   l+  +  +rk + ++++k
  EFC38142.1 487 SFIVAACFIGLTIAGNGFRTDVQSLTFLLLHGIVYVYFASLSFLLMPGKNEERKPELSASAK 548
                 689*********************77777777777777777766666666665544444444 PP

>> DUF2140  Uncharacterized protein conserved in bacteria (DUF2140)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.2   0.00035       1.6       7      61 ..      24      75 ..      20     101 .. 0.65
   2 ?    1.2   0.0     0.051   2.3e+02       6      43 ..     512     550 ..     510     569 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00035
     DUF2140  7 FliLlalllllvavvlvrvfapseestekssekekkseaeftitttkkqlnalin 61
                 liL+ +ll+++++v++ +fa+ e s    + ++++s++  ti tt ++l +  +
  EFC38142.1 24 ILILVLVLLIVGLFVIISLFASPEAS---VTVTRRHSSNGSTIVTTTNSLVEDYK 75
                46777888888888888888888885...56666666677777777777666555 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.051
     DUF2140   6 aFliLlalllllvavvlvrvfapseeste.kssekekks 43 
                  Fl+L +++ + +a + + ++  ++e+++ + s++ k+ 
  EFC38142.1 512 TFLLLHGIVYVYFASLSFLLMPGKNEERKpELSASAKEM 550
                 79**************99999988888765333333333 PP

>> FtsH_ext  FtsH Extracellular
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   1.2   0.00012      0.54       2      79 ..      26     118 ..      23     139 .. 0.66
   2 ?   -1.8   0.3      0.91   4.1e+03       6      30 ..     404     434 ..     400     435 .. 0.66
   3 ?   -1.1   0.0      0.52   2.3e+03       3      52 ..     512     583 ..     510     586 .. 0.53

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00012
    FtsH_ext   2 llwlllallllllllslfg...........gsgtgstkeisyseFledle.qgnvekvvvqestis...alirrptgdgvsttkkgnstttys 79 
                 +l l+l+++ l+++ slf             s++gst   + + ++ed++ + + ++ +v e ti+   + +++ +  ++ tt++g+++tt++
  EFC38142.1  26 ILVLVLLIVGLFVIISLFAspeasvtvtrrHSSNGSTIVTTTNSLVEDYKfITEQDRDEVLELTIEntiVEDNSTNSTTTDTTTDGGNSTTTN 118
                 333333333333333333358888888888666779999999*********888888888888888555455555555555555555555554 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.91
    FtsH_ext   6 llallllllllslfg......gsgtgstkei 30 
                 +++++++++l+++ +      +  ++s+++i
  EFC38142.1 404 IIIVGIGYILTLILMiwsrvyNVANPSSVDI 434
                 7888888888887766666665555566655 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.52
    FtsH_ext   3 lwlllallllllllslfg.......gsgtg.......stkeisy...seF........ledleqgnvekvvvqes 52 
                 ++lll +++ ++++sl++           +       s ke++    s+F        +ed +++++++vv+ ++
  EFC38142.1 512 TFLLLHGIVYVYFASLSFllmpgknE---ErkpelsaSAKEMDAndkSDFtkpssanrVEDDDEVQITDVVLSRN 583
                 56666677777777777766553330...2333333355555554466666666544444444666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (587 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1168  (0.0651459); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.52
# Mc/sec: 3424.79
//
Query:       EFC38143.1  [L=719]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.2e-28   97.5   0.2    1.5e-27   96.4   0.2    1.5  1  DUF21         Cyclin M transmembrane N-terminal domain
    2.3e-08   34.4   0.1     0.0015   18.9   0.0    2.8  2  CBS           CBS domain
    6.2e-06   26.2   0.0    1.3e-05   25.2   0.0    1.5  1  cNMP_binding  Cyclic nucleotide-binding domain
  ------ inclusion threshold ------
      0.098   12.5   0.2       0.39   10.5   0.0    2.2  2  DC_STAMP      DC-STAMP-like protein


Domain annotation for each model (and alignments):
>> DUF21  Cyclin M transmembrane N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   96.4   0.2   3.4e-31   1.5e-27       3     169 ..     143     304 ..     141     309 .. 0.94

  Alignments for each domain:
  == domain 1  score: 96.4 bits;  conditional E-value: 3.4e-31
       DUF21   3 ivlllllsaffsgaEtAlvslsrlrl....eelaekgkkkakrllkllknperlLstlligntlvnillsalatalfvellaegalavviatviv.tll 96 
                  ++++l+++++sg +++l+s+++++l    ++  ek++k+a+rl ++lk+++ lL+tll+ n l+   l++++++l+ e+ a          +++  ++
  EFC38143.1 143 SMFFILGAGLMSGFTLGLLSIDTMQLdilkSTGTEKERKYAARLAPILKRHHLLLVTLLLWNALCVECLPLFLDKLVPEWAA----------ILLgITF 231
                 579999********************6665555555669****************************************998..........8888*** PP

       DUF21  97 ilvfgEilPkslalkyaekialalapplrvlmvllyPlvwllskllnlilesesepavseeelkklveeseee 169
                 +l+fgE++P+s+  +y  +i   l +++ +l+ l + +++++skll+++l+s++++ +++ elk+lv+++ ++
  EFC38143.1 232 VLLFGEVIPQSVISRYGMAIGGTLYWLVWFLIGLAFVIAYPISKLLDWMLGSDHGTLYKRTELKELVNIHSKA 304
                 *********************************************************************9876 PP

>> CBS  CBS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0   3.6e-05      0.16      28      53 ..     360     386 ..     329     389 .. 0.83
   2 !   18.9   0.0   3.4e-07    0.0015       7      55 ..     404     461 ..     400     463 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.6e-05
                 HTSSEEEEE..ETTTBEEEEEEHHHHHH CS
         CBS  28 kgvsrlPVV..dedgklvGivtlrDllr 53 
                 +g+sr+PV   d++ ++vG++  +Dl+ 
  EFC38143.1 360 AGHSRIPVFkgDKN-NVVGLLYVKDLIL 386
                 679******85555.5**********85 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 3.4e-07
                 SSCEEEETTSBHHHHHHHHHHHTSSEEEEE.....ETTTB........EEEEEEHHHHHHHH CS
         CBS   7 rdvvtvppdttleealelmrekgvsrlPVV.....dedgk........lvGivtlrDllral 55 
                 r+v+ v pdt   e l+++ ++g +++ +V         +        +vGiv+l+D+++ +
  EFC38143.1 404 REVLKVFPDTYCDEMLKTF-KSGRTHIAIVqepreS---EtggdpyyaIVGIVSLEDIIEEI 461
                 57899**************.666569*9**887652...134567778***********987 PP

>> cNMP_binding  Cyclic nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.2   0.0   2.8e-09   1.3e-05      10      88 ..     551     626 ..     546     627 .. 0.89

  Alignments for each domain:
  == domain 1  score: 25.2 bits;  conditional E-value: 2.8e-09
                   EE-TTSB-SEEEEEEES-EEEEEEETTS.EEEEEEE-TTEEESHHHHHHTS-.-SSEEEESSTEEEEEEEHHHHHHHHHH CS
  cNMP_binding  10 ifrqGdpadslyivlsGevrvyrlsedgkevvlavlgpGdlfGelalltgep.rtatvvAltdsellalprddflellqq 88 
                   ++++++++d++ +v sG+++ +    +   + + ++gp +++Ge+al +++    ++v+ + d++ ++++++df e+++q
    EFC38143.1 551 LIEKNKECDYFALVFSGKLEAV--FCEE--KFTSEMGPWSFIGERALTRETFiPDYDVRIVKDVTFVKITKKDFIEIISQ 626
                   8999*****************4..5555..5789**************755579***********************986 PP

>> DC_STAMP  DC-STAMP-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   8.7e-05      0.39     126     182 ..      17      74 ..       2      80 .. 0.79
   2 ?   -2.5   0.1      0.88   3.9e+03     135     139 ..     210     214 ..     174     251 .. 0.56

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 8.7e-05
    DC_STAMP 126 vklelsnskClpkpsepd.savviqigllllllivlvlleayllRlrrliaasFypkr 182
                  + + +n +C p ps+p+ +++ + ++lll+lli++vl +    +    +++ + p r
  EFC38143.1  17 DHNRKENPNCPPPPSPPPiKKRSFSLVLLLALLILVVLATFSYEQHSMFVVEGYVPTR 74 
                 44677899******87762678999999999999999999888998888888887776 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.88
    DC_STAMP 135 Clpkp 139
                 Clp  
  EFC38143.1 210 CLPLF 214
                 33333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (719 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       758  (0.0422779); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 4140.25
//
Query:       EFC38144.1  [L=404]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.8    9.1  19.5          6    7.4   0.9    6.0  4  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   2.2     0.053   9.6e+02      22      33 ..      60      69 ..      37      97 .. 0.56
   2 ?    1.4   0.0     0.026   4.7e+02       6      30 ..     116     139 ..     105     153 .. 0.62
   3 ?    7.0   0.5   0.00046       8.3       2      31 ..     156     186 ..     155     202 .. 0.75
   4 ?    7.4   0.9   0.00033         6      15      43 ..     216     247 ..     214     262 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.053
                -TT--EEE-.-S CS
       LRR_4 22 lpnLkeLdLsgN 33
                + nL  L +  N
  EFC38144.1 60 ISNLSRLEI--N 69
                445555544..2 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.026
                 EE--SS---E-S-.HHH-TT--EEE- CS
       LRR_4   6 LdLsnNqltdipl.leklpnLkeLdL 30 
                 L L    ++ +++  +++p+L+ + +
  EFC38144.1 116 LELLR--VRNLEGaSNSFPSLEFVKC 139
                 33332..4444442445888887776 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.00046
                 S--EEE--..SS---E-S-HHH-TT--EEE-. CS
       LRR_4   2 nLevLdLs..nNqltdiplleklpnLkeLdLs 31 
                 +L++L L   + +l++   ++ ++ L+eL+++
  EFC38144.1 156 KLKSLILDkcDFKLQSNVEFQ-CKELEELNIT 186
                 789999993334588877799.********93 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.00033
                 E-S-HHH-TT--EEE-...-.S-----GGGGX CS
       LRR_4  15 diplleklpnLkeLdL..sg.NnlitdldeLk 43 
                 d++++e++ +L++L++  s  N  +++l++Lk
  EFC38144.1 216 DLSPIEQMISLEYLSIlsSYqNISLKKLTNLK 247
                 7899999********87533476667777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (404 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       599  (0.0334096); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 2363.41
//
Query:       EFC38145.1  [L=445]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.6e-22   78.5   0.0    6.5e-22   78.0   0.0    1.2  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    1.1e-15   57.9   0.0    5.8e-15   55.6   0.0    2.0  2  GTP_EFTU_D3  Elongation factor Tu C-terminal domain
    0.00053   20.3   0.1     0.0024   18.2   0.0    2.2  2  GTP_EFTU_D2  Elongation factor Tu domain 2
  ------ inclusion threshold ------
      0.024   13.8   0.1      0.034   13.3   0.1    1.3  1  G-alpha      G-protein alpha subunit
      0.032   13.6   0.3       0.18   11.2   0.3    2.1  1  SRPRB        Signal recognition particle receptor beta subuni
      0.033   14.1   0.1       0.11   12.4   0.1    1.9  1  NTPase_1     NTPase
       0.04   14.0   0.1       0.14   12.2   0.1    1.9  1  MMR_HSR1     50S ribosome-binding GTPase
       0.14   12.8   0.0       0.25   11.9   0.0    1.5  1  AAA_18       AAA domain


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.0   0.0   2.9e-25   6.5e-22       3     179 ..       6     193 ..       4     231 .. 0.81

  Alignments for each domain:
  == domain 1  score: 78.0 bits;  conditional E-value: 2.9e-25
                 EEEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH...HHHST..............HCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGH CS
    GTP_EFTU   3 irnigiighvDhGKtTLtdrLlyktgaiskkgeka...eeerv..............lDtlkeErergiTiksaaisleketkkylinliDtPGHvdFs 84 
                 ++ ++i+g  ++GKtTL  +Ll+++g+i+++ +++   +   +              l ++k+E +rg T++      e  tk++++n+iD+P    F 
  EFC38145.1   6 TLSVIILGQANSGKTTLAVQLLHSLGTINSSIMERvesG---MqldssdsirnyasvLSRTKDEIKRGRTMNLVYSMAE--TKHFHLNIIDAP-ANPFL 98 
                 6789**************************888885331...245788889999999****************999888..************.578** PP

                 HHHHHHHHT-SEEEEEEETTTB.....STHHHHHHHHHHHHTTTEEEEEEESCGST...HHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBT CS
    GTP_EFTU  85 kevirglrvlDgavlvvdaveG.....vepqteevlrlalkegvpiivfiNKmDrl...kaelkeiveevkqklsrkeeklekygekgekevpvvfgSa 175
                 k + rg++++++ ++v+da+ G     + + t  +        +++i+++NKm  +   k+++ ei++e+ + +       ++ g+k+  + +v+++Sa
  EFC38145.1  99 KSMFRGISQANIGIVVLDAEIGafeagIPNITTMIRATYCLGSIQLIFCVNKMESVdysKTRFMEIKSEITKIY-------KNNGYKNG-NATVIPISA 189
                 ********************7755553444444444444556688********9999999***********555.......77788874.899999999 PP

                 TTTB CS
    GTP_EFTU 176 lkge 179
                 l+  
  EFC38145.1 190 LSSL 193
                 9865 PP

>> GTP_EFTU_D3  Elongation factor Tu C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.76   1.7e+03      14      43 ..     263     295 ..     256     324 .. 0.61
   2 !   55.6   0.0   2.6e-18   5.8e-15       3     111 ..     332     437 ..     330     438 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.76
                  ESSS.....SS-BSTT-EEEEESSS-EEEEEEE CS
  GTP_EFTU_D3  14 ileke...rhtpitagYrpvlyirtadvtgkvv 43 
                  il+ e   r tp  +++ p + i +  +  k v
   EFC38145.1 263 ILKLEteiRLTPHKKQFPPSMKIESIAICRKLV 295
                  444444488888999999999988887754333 PP

  == domain 2  score: 55.6 bits;  conditional E-value: 2.6e-18
                  EEECCEEEEEEESSS..SS-BSTT-EEEEESSS-EEEEEEEEEEECCSSTTSB-BSS-SSCCSTT-CEEEEEEECCEEEE--TTTHCCCCEEEEECTT CS
  GTP_EFTU_D3   3 kphtkfeAqvyilekerhtpitagYrpvlyirtadvtgkvveLlskldkktekvsekkpefvkpGdnvivevelikpialekgseypqlGrFaiRegg 100
                  k++++f+A +++l++   +p+  gY+p + i++ + ++k++++  + +  +  + +++p+ +++G+ ++v ++++++i + ++  yp++GrF + ++g
   EFC38145.1 332 KEVHSFKADIAVLRE---SPFRRGYNPTFNIHSLQTSCKFKDFYVSSNTIKRYERDENPMELRKGQYATVLLKPKNQIYVATVYSYPPFGRFLMWDNG 426
                  7899*********98...*************************88777777777779***************************************** PP

                  CEEEEEEEEEE CS
  GTP_EFTU_D3 101 rTvaaGvvtei 111
                  +    Gv+te+
   EFC38145.1 427 NICVFGVITEV 437
                  *********98 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       3.9   8.7e+03      29      43 ..     162     176 ..     151     178 .. 0.71
   2 !   18.2   0.0   1.1e-06    0.0024       3      73 ..     254     323 ..     252     324 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3.9
                  EEEEEEEEEEEEETE CS
  GTP_EFTU_D2  29 keivtrissletfhe 43 
                   ei+++i++++++++
   EFC38145.1 162 MEIKSEITKIYKNNG 176
                  348899999998875 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 1.1e-06
                  EEEEEEEESEEETTEEEEEECTCTTSEE.EEEEEEEEEEETEEESEEETTSEEEEEEEESSCCSGSSTTCEE CS
  GTP_EFTU_D2   3 valgrvysGtlkkGdevrilgndtskke.ivtrissletfhededeavaganaGvivaikgledaiivGdtl 73 
                  v++g++++G+lk   e+r+ +   +k++    +i s+   ++ ++ea ag+ + + ++     + ++ G++l
   EFC38145.1 254 VVFGKIETGILKLETEIRLTP--HKKQFpPSMKIESIAICRKLVREAKAGQLVTIQLKTSLNPSNVKPGMVL 323
                  8******************66..32333599********************999988754333346666665 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   1.5e-05     0.034      23     110 ..       6      91 ..       2     188 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.5e-05
                 EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHC.CHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH. CS
     G-alpha  23 evkllllGqseSGKsTilkqlkllykkgfseeelat.wraviqlnivrsiktilealesleselsesfelqelkerldplkkveaslia 110
                 ++++++lGq+ SGK+T+   ++ll+  g  ++ + +   + +ql   +si++    l+++++e+ ++   ++l  ++++ k+++ ++i+
  EFC38145.1   6 TLSVIILGQANSGKTTLA--VQLLHSLGTINSSIMErVESGMQLDSSDSIRNYASVLSRTKDEI-KRGRTMNLVYSMAETKHFHLNIID 91 
                 56899************5..55678777667767444899999999999999999999977777.444566666666666666555554 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.3   8.1e-05      0.18       5      35 ..       8      40 ..       4     117 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.1e-05
                EEEEE-STTSSHHHHHHHHHHS..S---B---S CS
       SRPRB  5 avllvGlsdsGKTslftrLttd..svkktvtSq 35
                +v+++G  +sGKT+l  +L+    +++++ +  
  EFC38145.1  8 SVIILGQANSGKTTLAVQLLHSlgTINSSIMER 40
                69****************997644555555544 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   4.9e-05      0.11       2     136 ..       9     152 ..       8     179 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 4.9e-05
                 EEEE--TTSSHHHHHHHHHHHH...GGGEEEEEEEEE-------EEEEEET.T--EEEEEETT....---SSEETTEEE-HHHHHHHHHHHHHHHH... CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlellkssgvkvgGfyteevreggrrigFkivdlasgeegiLarve....akreprvgkyvvdvesfeelalealrkal... 93 
                 v+i G+  +GKtTl  ++l+ l   + ++   + + ++ + + +  ++ ++ s +++++ r +      + ++ +++++++  ++  a + l+ ++   
  EFC38145.1   9 VIILGQANSGKTTLAVQLLHSLGTINSSIMERVESGMQLDSSDSIRNYASVLSRTKDEIKRGRtmnlVYSMAETKHFHLNI--IDAPANPFLKSMFrgi 105
                 7899******************99999999999999998899999999999999999999988777666666777777765..4444444444444333 PP

                 HHH-..EEEE-.--STTGGG-HHHHHHHHHHHT.TTSEEEEE--SS- CS
    NTPase_1  94 sead..viviD.EiGkmElkskkfkeaveevLk.sekpvlavihrrk 136
                 s+a+  ++v+D EiG +E  ++++ ++++ +    + ++++ + + +
  EFC38145.1 106 SQANigIVVLDaEIGAFEAGIPNITTMIRATYClGSIQLIFCVNKME 152
                 55555599**99*****************998877777777777765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   6.3e-05      0.14       2      86 ..       9     118 ..       8     150 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.3e-05
                 EEEEESTTSSHHHHHHHHHT................................STEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltg................................ekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgk 68 
                 v+i+G+ N+GK+tL  +l+                                 ++ + + k g T + ++   ++k+ +++++D p           l+ 
  EFC38145.1   9 VIILGQANSGKTTLAVQLLHslgtinssimervesgmqldssdsirnyasvlSRTKDEIKRGRTMNLVYSMAETKHFHLNIIDAPA-NP------FLKS 100
                 89****************95444444444444444444444444443432222333333445555555555555556678888887.33......3666 PP

                 HHHHHHCTSEEEEEEETT CS
    MMR_HSR1  69 aflaleeadlillvvdas 86 
                  f+ + +a++ ++v+da+
  EFC38145.1 101 MFRGISQANIGIVVLDAE 118
                 666666677777777755 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00011      0.25       1      66 [.       9      81 ..       9     118 .. 0.55

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
      AAA_18  1 IlltGtpGvGKttlakeLskrlgf.............gvnlrdvakenglllevdpe.....aldeskrldedkldklldalee 66
                +++ G + +GKttla  L  +lg                 ++d +                   + +++++++++++l+  + e
  EFC38145.1  9 VIILGQANSGKTTLAVQLLHSLGTinssimervesgmQLDSSDSI-----------RnyasvLSRTKDEIKRGRTMNLVYSMAE 81
                799***************777744454443333333333333333...........2333333444444444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       487  (0.0271627); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 2571.37
//
Query:       EFC38146.1  [L=359]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        5.9    7.0  24.7        1.2    9.2  17.7    2.1  2  PARM           PARM
        7.2    6.7   6.1        7.3    6.6   0.3    3.3  3  DASH_Dad4      DASH complex subunit Dad4


Domain annotation for each model (and alignments):
>> PARM  PARM
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.6     0.018   1.6e+02     152     189 ..      31      63 ..      17     115 .. 0.57
   2 ?    9.2  17.7   0.00014       1.2     114     228 ..     208     323 ..     171     335 .. 0.59

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.018
        PARM 152 ppevssasvstnhssaetstkptgapttpespteehss 189
                    v      ++++ ++tst +++a +++++  + ++s
  EFC38146.1  31 TQAVK-----SSSIVKKTSTTNKKATKPKKTWKKAKKS 63 
                 22223.....3333333333333333333333322222 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00014
        PARM 114 gtpeasvpatgsqs..paesptltSpqapasspsslstslppevssasvstnhssaetstkptgapttpespteehssaetptshataepvpeettsqa 210
                 +  +as+ ++++qs  ++ ++  +S+   +ss +s+s++   +    s    +ssa+ s+k++ +p++++s t+ +s ++++ s+++++  +  ++ ++
  EFC38146.1 208 KKRNASAQQAETQSvqTTATARKSSSSKKSSSKKSTSST-TKKSGKKSGKKTNSSAKKSSKKKTTPKKKNSSTKKTSKKKAKKSKKASKCAKLRRSLRK 305
                 333344444444443122222222222222334444443.44444455556667777777777777777888877777777777777777777777777 PP

        PARM 211 tvpakvtcelvdtestta 228
                 t+ a   ++ + t s++a
  EFC38146.1 306 TILAVKKLKKTATTSNAA 323
                 776665555444444444 PP

>> DASH_Dad4  DASH complex subunit Dad4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1     0.036   3.2e+02      17      43 ..      70      96 ..      38     104 .. 0.85
   2 ?   -2.7   0.1      0.68   6.1e+03      22      33 ..     199     210 ..     185     228 .. 0.50
   3 ?    6.6   0.3   0.00081       7.3      17      44 ..     329     356 ..     326     358 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.036
   DASH_Dad4 17 iknvekLnesvvelnkeleeinkkNkn 43
                 k v+kL ++v +l+ +l++  kk k+
  EFC38146.1 70 AKRVKKLRSKVRKLKLKLKKKCKKSKK 96
                567999999999999999887666655 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.68
   DASH_Dad4  22 kLnesvvelnke 33 
                 ++ ++ + l+k+
  EFC38146.1 199 RCAKKAKSLKKR 210
                 333333333332 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.00081
   DASH_Dad4  17 iknvekLnesvvelnkeleeinkkNknv 44 
                 +kn++kL  ++v+l+ +l++ + k+k++
  EFC38146.1 329 LKNIKKLRAKIVKLKASLKKLKCKTKKI 356
                 69******************99998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (359 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4847  (0.270344); expected 358.6 (0.02)
Passed bias filter:                      839  (0.0467957); expected 358.6 (0.02)
Passed Vit filter:                       533  (0.0297284); expected 17.9 (0.001)
Passed Fwd filter:                       142  (0.00792013); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 2.44u 0.43s 00:00:02.87 Elapsed: 00:00:00.77
# Mc/sec: 1399.77
//
Query:       EFC38147.1  [L=410]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-68  225.5  12.8    8.9e-17   60.6   0.0    7.6  9  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.25   11.6   1.3         39    4.6   0.0    3.2  3  DUF3107   Protein of unknown function (DUF3107)
       0.31   11.1   5.8       0.16   12.0   1.3    2.8  2  DUF1154   Protein of unknown function (DUF1154)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1     0.014        85      20      38 ..     111     129 ..     109     141 .. 0.80
   2 !   16.2   0.0   1.1e-06    0.0066       1      49 []     117     166 ..     117     166 .. 0.87
   3 !   35.4   0.0     1e-12   6.3e-09       1      38 [.     143     180 ..     143     183 .. 0.96
   4 !   60.6   0.0   1.5e-20   8.9e-17       1      49 []     168     216 ..     168     216 .. 0.99
   5 !   43.7   0.0   2.7e-15   1.6e-11       1      49 []     218     268 ..     218     268 .. 0.96
   6 !   26.7   0.0   5.6e-10   3.4e-06      13      48 ..     257     293 ..     255     294 .. 0.92
   7 !   21.7   0.2     2e-08   0.00012       1      35 [.     270     305 ..     270     317 .. 0.92
   8 !   50.2   0.5   2.6e-17   1.6e-13       1      49 []     324     372 ..     324     372 .. 0.99
   9 !   22.9   0.8   8.8e-09   5.3e-05       1      35 [.     374     408 ..     374     410 .] 0.93

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.014
     DUF4116  20 seeLknDkeivlkAvkqng 38 
                  +eLk D +++ ++v +++
  EFC38147.1 111 GKELKFDSNFIFQIVGISP 129
                 589***********98776 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 1.1e-06
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D  ++ ++v +  g+++++ +e ++nD+e+vl+ vk  g+ ls as+ L+
  EFC38147.1 117 DSNFIFQIVGISpGFIYNNSNEVIRNDREVVLRSVKGVGSMLSIASDRLK 166
                 66788888885538999999999*************999***99999886 PP

  == domain 3  score: 35.4 bits;  conditional E-value: 1e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 DrE+vl  vk  gs l  +s++Lk D+eiv++Avkq+g
  EFC38147.1 143 DREVVLRSVKGVGSMLSIASDRLKDDREIVMAAVKQDG 180
                 9***********************************99 PP

  == domain 4  score: 60.6 bits;  conditional E-value: 1.5e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+ avk++g +l y+++++k+D+eiv++A k++g+al++++e+Lr
  EFC38147.1 168 DREIVMAAVKQDGGSLGYANDRFKSDREIVMAAAKSSGHALKFVHESLR 216
                 9**********************************************98 PP

  == domain 5  score: 43.7 bits;  conditional E-value: 2.7e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng..talsyaseeLr 49 
                 DrEiv  a+++++s +  + ee+knD+ei++kA+ +n   +a+ yas eL+
  EFC38147.1 218 DREIVELAISHCWSFIGSAGEEIKNDREIIMKAIMRNEqgSAFQYASRELK 268
                 9**********************************988668*******997 PP

  == domain 6  score: 26.7 bits;  conditional E-value: 5.6e-10
     DUF4116  13 gsalkylseeLknDkeivlkAvkqng.talsyaseeL 48 
                 gsa++y+s eLk Dk +vl+ v++++ +al+ya eeL
  EFC38147.1 257 GSAFQYASRELKLDKKFVLEVVRKSKgFALEYALEEL 293
                 89*********************7666********99 PP

  == domain 7  score: 21.7 bits;  conditional E-value: 2e-08
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvk 35 
                 D+ +vle+v+k  g+al+y+ eeL +D+e++ ++++
  EFC38147.1 270 DKKFVLEVVRKSkGFALEYALEELIKDREFLVEILE 305
                 999*******8889*****************99987 PP

  == domain 8  score: 50.2 bits;  conditional E-value: 2.6e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+++l   k +g+++ky+++e+k+Dkeiv +Av qn +++ +++++Lr
  EFC38147.1 324 DRDLILLTAKYDGFIIKYINPEFKKDKEIVFEAVSQNVNVFQHIDKSLR 372
                 9**********************************************98 PP

  == domain 9  score: 22.9 bits;  conditional E-value: 8.8e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 D+E+vl + +kn++++++l +++k+D e++ ++ k
  EFC38147.1 374 DKEFVLRLARKNSKIIQFLTKSMKKDHEFMSQINK 408
                 9*****************************98755 PP

>> DUF3107  Protein of unknown function (DUF3107)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.95   5.7e+03      10      31 ..     142     163 ..     139     180 .. 0.54
   2 ?    4.6   0.0    0.0066        39      10      42 ..     192     224 ..     190     228 .. 0.93
   3 ?    4.2   0.1    0.0085        51      11      42 ..     349     381 ..     346     392 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.95
     DUF3107  10 saRelvieseqsadeveaavee 31 
                 + Re+v++s +    + +  ++
  EFC38147.1 142 NDREVVLRSVKGVGSMLSIASD 163
                 5667776665544444443333 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0066
     DUF3107  10 saRelvieseqsadeveaaveealagdegvltL 42 
                 s Re+v+  ++s+ +  + v+e l++d ++++L
  EFC38147.1 192 SDREIVMAAAKSSGHALKFVHESLRNDREIVEL 224
                 78*************************999998 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.0085
     DUF3107  11 aRelvieseqsadeveaaveealagdeg.vltL 42 
                  +e+v+e  +++ +v +++++ l++d++ vl+L
  EFC38147.1 349 DKEIVFEAVSQNVNVFQHIDKSLRDDKEfVLRL 381
                 689*********************443314444 PP

>> DUF1154  Protein of unknown function (DUF1154)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.2      0.75   4.5e+03      12      19 ..     267     274 ..     265     282 .. 0.68
   2 ?   12.0   1.3   2.7e-05      0.16      10      43 ..     369     403 ..     363     404 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.75
     DUF1154  12 LkqdKayl 19 
                 Lk dK+++
  EFC38147.1 267 LKLDKKFV 274
                 77777774 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 2.7e-05
     DUF1154  10 esLkqdKay.lKllKKQqKElesLkKkhsKersav 43 
                  sL+ dK++ l+l++K +K ++ L K  +K++  +
  EFC38147.1 369 KSLRDDKEFvLRLARKNSKIIQFLTKSMKKDHEFM 403
                 48*******56*********************877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       790  (0.0440627); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.25s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 2667.35
//
Query:       EFC38148.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2673  (0.149088); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1419.17
//
Query:       EFC38149.1  [L=798]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
        7.2    7.0  10.9       0.13   12.6   1.6    2.7  3  DUF3134    Protein of unknown function (DUF3134)


Domain annotation for each model (and alignments):
>> DUF3134  Protein of unknown function (DUF3134)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.2      0.11   1.9e+03      34      59 ..     403     429 ..     402     434 .. 0.76
   2 ?   12.6   1.6   7.2e-06      0.13      28      61 ..     444     479 ..     443     489 .. 0.87
   3 ?   -3.1   0.1      0.57     1e+04      31      48 ..     695     712 ..     693     718 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.11
     DUF3134  34 Liardeeeeeele.eeeeeiseLmggd 59 
                 L++r++ e+e+++    eei++L+   
  EFC38149.1 403 LLKREKTEKEKQQdLIFEEIAKLLTNP 429
                 789999999999755568888887665 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 7.2e-06
     DUF3134  28 LessGRLiardeeeeeele..eeeeeiseLmggddd 61 
                 L +++RL++++++++++++  +eeee ++L++ +d+
  EFC38149.1 444 LDTNNRLVYDNNDQQDNYSlpKEEEEADNLLNIEDE 479
                 789********9999999999**********99883 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 0.57
     DUF3134  31 sGRLiardeeeeeeleee 48 
                  +R+++r  + +++++ e
  EFC38149.1 695 DNRILKRKRKISNVSSFE 712
                 699999999998888733 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (798 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2757  (0.153773); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.83u 0.28s 00:00:01.10 Elapsed: 00:00:00.47
# Mc/sec: 5137.11
//
Query:       EFC38150.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.017   14.7  11.5      0.033   13.8  11.5    1.4  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8  11.5   1.8e-06     0.033      54     122 ..     264     332 ..     220     343 .. 0.42

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.8e-06
       SR-25  54 ekkkkkrrrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkakekaka 122
                   + + ++r++ssssssss+s+ ss +  ss s + k   ++    ++ k+ k+++k +k+k++ +++ 
  EFC38150.1 264 VSSFESEKRKTSSSSSSSSTSNVSSIGNNSSLSTTFKTPLNNCIVISNPKHLKRRRKYQKRKNSANTNP 332
                 111122233334444444444444444444444444444444444555555556666666666543333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1280  (0.0713927); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.47
# Mc/sec: 2214.25
//
Query:       EFC38151.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       848  (0.0472977); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1032.22
//
Query:       EFC38152.1  [L=181]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       802  (0.044732); expected 358.6 (0.02)
Passed bias filter:                      313  (0.0174578); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1132.33
//
Query:       EFC38153.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00035   21.2   6.8     0.0006   20.4   6.8    1.3  1  Pre-SET   Pre-SET motif


Domain annotation for each model (and alignments):
>> Pre-SET  Pre-SET motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   6.8   3.3e-08    0.0006       7      84 ..      60     138 ..      53     151 .. 0.68

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 3.3e-08
                 SS-EEEE-SSSS--CGCCSEE-SS-EE-TTS--CCC--.....----TTC..C-TCCTTSCCCT..CTTTSB-SSBBTTTSB CS
     Pre-SET   7 kvpipvvnevdselppakfeYikknilsegvedkeslarseesgCeCkgd..ClsssskcaCaq..keeeeeflaYdekgll 84 
                   +ip++n+ ++ ++ ++f+Y ++  ++++ + + s ++ ++s C+C+++  C   + +c+C+   + ++ +   Y+++++ 
  EFC38153.1  60 LNTIPIINNQKKRKISSSFKYYTSPNTEKKKKISISSTSITTSSCHCSNNvyC---KLSCNCIVnsNPKHLKRREYQKRKTY 138
                 5689*****9999999*****99999977777333333346789999666568...57899988543333444566665444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1437  (0.0801495); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1056.34
//
Query:       EFC38154.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2894  (0.161414); expected 358.6 (0.02)
Passed bias filter:                      204  (0.0113782); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 2333.34
//
Query:       EFC38155.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1445.44
//
Query:       EFC38156.1  [L=548]
Description: SH3 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-15   56.7   0.1    2.4e-15   55.9   0.1    1.4  1  SH3_1     SH3 domain
    1.6e-11   43.9   0.0    2.7e-11   43.2   0.0    1.4  1  SH3_9     Variant SH3 domain
    3.2e-11   42.7   0.0    5.4e-11   42.0   0.0    1.4  1  SH3_2     Variant SH3 domain
    1.9e-07   31.1   1.4    1.9e-07   31.1   1.4    2.8  3  BAR_3     BAR domain of APPL family
    0.00095   18.8   0.5     0.0019   17.8   0.0    1.7  2  Arfaptin  Arfaptin-like domain
  ------ inclusion threshold ------
       0.02   14.6   0.1       0.02   14.6   0.1    2.0  2  BAR       BAR domain


Domain annotation for each model (and alignments):
>> SH3_1  SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.9   0.1   7.9e-19   2.4e-15       1      48 []     493     542 ..     493     542 .. 0.98

  Alignments for each domain:
  == domain 1  score: 55.9 bits;  conditional E-value: 7.9e-19
                 EESSSBEXSSTTBXEBSTTEEEEEEEECSS.SEEEEEETTS.TEEEEEEG CS
       SH3_1   1 iAlYDYeaeesdELsfkkGDviivleksed.gWwkgrlkgt.gkeGliPs 48 
                 +A+Y+Y+a++s+E++fk+GD+i + ek+ d gWwkg + ++  ++G++Ps
  EFC38156.1 493 KAIYPYNAQSSEEITFKPGDIILIFEKEQDyGWWKGTVESDlERKGMFPS 542
                 7**************************************99999*****8 PP

>> SH3_9  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.2   0.0     9e-15   2.7e-11       1      49 []     494     546 ..     494     546 .. 0.89

  Alignments for each domain:
  == domain 1  score: 43.2 bits;  conditional E-value: 9e-15
       SH3_9   1 AlypyepreddeLsLqrGDvitvi.eesedgWlegs...ltGrtGlvPanyve 49 
                 A+ypy++++ +e+ + +GD+i++  +e + gW+ g+     +r+G +P+nyv+
  EFC38156.1 494 AIYPYNAQSSEEITFKPGDIILIFeKEQDYGWWKGTvesDLERKGMFPSNYVQ 546
                 89*********************8355789*****8653488**********7 PP

>> SH3_2  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.0   0.0   1.8e-14   5.4e-11       2      56 ..     492     547 ..     491     548 .] 0.92

  Alignments for each domain:
  == domain 1  score: 42.0 bits;  conditional E-value: 1.8e-14
                 EEESS-B-SCGCCB--B-TTEEEEEE..EEEECT.TEEEEEE.C..CCEEEEEGCGEEE CS
       SH3_2   2 vraiedyvgedkseLsfkkGdvikvlslgskdsd.gwwegev.g..GrvGlfPsslvee 56 
                 ++ai  y++++ +e++fk Gd+i ++   +k++d gww+g+v     r+G fPs++v++
  EFC38156.1 492 CKAIYPYNAQSSEEITFKPGDIILIF---EKEQDyGWWKGTVeSdlERKGMFPSNYVQI 547
                 789999********************...***********995267***********98 PP

>> BAR_3  BAR domain of APPL family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.1   1.4   6.3e-11   1.9e-07      22     139 ..      13     129 ..       5     130 .. 0.90
   2 !    4.7   1.6    0.0073        22     181     220 ..     119     158 ..     115     175 .. 0.80
   3 ?   -1.8   0.4      0.67     2e+03     150     164 ..     413     427 ..     381     438 .. 0.45

  Alignments for each domain:
  == domain 1  score: 31.1 bits;  conditional E-value: 6.3e-11
       BAR_3  22 aeleelekklkkllKlckrlieagkaysaaqkqfaqsLrelkkeskgdeetdesLkkfsellqelenehtilldqaqrsikkpLekFrkedlkevk.ek 119
                 ++ ++  k++++ +K++++++++++ + + q++f + L++l  e+  ++e+ e+L k++++l+ ++    ++l +++++  +p+++Frk+ +++    +
  EFC38156.1  13 DDYDKAAKYIDNSVKNIRSYCQKANLTTDLQNEFGDYLKDLGLEN--EDELGETLIKLGDCLKSMATLNHVMLCNIEDNYLQPISEFRKDLVGNNDlSS 109
                 6789999***********************************987..56799*************************************9999877688 PP

       BAR_3 120 kkkFdkesekleaaleknaq 139
                  +++ k+  k e+ +++ +q
  EFC38156.1 110 AEQYAKKCLKQEEHMKQLLQ 129
                 88999988888888877765 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0073
       BAR_3 181 kkfeiletllsfmqaqltFfhqGyelfkdlepfmkeLsaq 220
                 k+ e +++ll+++   + ++ +Gy l+  l++ +++++++
  EFC38156.1 119 KQEEHMKQLLQYFMCFYHYYSEGYTLTFHLKEPLEKIKDR 158
                 566889*********************8888877777765 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.67
       BAR_3 150 eeadnelkatrkkfh 164
                  ++++el+++ ++f 
  EFC38156.1 413 TNSSEELSSSVSSFK 427
                 233333333333332 PP

>> Arfaptin  Arfaptin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   6.5e-07    0.0019      42     106 ..      15      78 ..       9      98 .. 0.87
   2 ?   -3.2   0.2       1.7     5e+03      12      45 ..     395     429 ..     387     434 .. 0.53

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 6.5e-07
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..H-CCGHHHHHHHHHHHHHHHHH CS
    Arfaptin  42 lreiketykelvklaknlskallklsqtekelGdvfkdlskrekqealgeaftatgealrllakq 106
                 + + ++   + vk+++ + ++ +  +  ++e+Gd++kdl+  e + +lge + + g+ l+++a  
  EFC38156.1  15 YDKAAKYIDNSVKNIRSYCQKANLTTDLQNEFGDYLKDLGL-ENEDELGETLIKLGDCLKSMATL 78 
                 566677778889*****************************.9**************99988764 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.7
                 XXXXXXXXXXXX--....C.HHHHHHHHHHHHHHH CS
    Arfaptin  12 tkqvlseklgkkedervit.vddeLeaklevlrei 45 
                 t+q  s++  +k +++vit + +eL + +  ++++
  EFC38156.1 395 TQQTNSDTSSTKPQNKVITnSSEELSSSVSSFKKN 429
                 44445555555555555542344555555555544 PP

>> BAR  BAR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.1   6.6e-06      0.02      36     134 ..      16     100 ..       4     106 .. 0.81
   2 ?   -3.2   1.0       1.7   5.1e+03     205     238 ..     120     153 ..     115     154 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 6.6e-06
         BAR  36 dvteklieklvkelkeylqanpgarakqivleklkeqplelLaesmieagkelgedssfgkalekygeavkklaqteeelekrvetnfldplrelleke 134
                 d+  k i++ vk +++y q  + ++  q            ++++++ ++g e   ++++g++l+k+g+ +k +a++ + +  ++e+n l+p+ e+  k+
  EFC38156.1  16 DKAAKYIDNSVKNIRSYCQKANLTTDLQN-----------EFGDYLKDLGLEN--EDELGETLIKLGDCLKSMATLNHVMLCNIEDNYLQPISEFR-KD 100
                 55567788888888888884444444444...........8999999999877..55569*********************************998.65 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.7
         BAR 205 evefvnqlqafveaqldfhkqaaqlleqlqqqls 238
                 + e+++ql +++   + ++ + ++l  +l++ l+
  EFC38156.1 120 QEEHMKQLLQYFMCFYHYYSEGYTLTFHLKEPLE 153
                 5677899999999999999999999999988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (548 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1592  (0.0887947); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.84u 0.31s 00:00:01.14 Elapsed: 00:00:00.52
# Mc/sec: 3172.70
//
Query:       EFC38157.1  [L=536]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-14   53.1   0.4       0.07   13.8   0.0    6.3  5  RCC1      Regulator of chromosome condensation (RCC1) repeat
    7.2e-07   28.9  10.7    0.00024   20.8   0.5    5.7  6  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
       0.11   11.3   0.4       0.15   10.8   0.4    1.1  1  Treacle   Treacher Collins syndrome protein Treacle


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0   0.00079       4.7       2      49 ..      14      83 ..      13      84 .. 0.67
   2 !   13.8   0.0   1.2e-05      0.07      26      50 .]     122     150 ..     104     150 .. 0.90
   3 !   13.7   0.0   1.2e-05     0.073       3      31 ..     155     184 ..     153     237 .. 0.63
   4 ?    3.1   0.0     0.026   1.5e+02       1      14 [.     241     254 ..     241     263 .. 0.91
   5 !    5.1   0.0    0.0062        37       7      31 ..     396     421 ..     395     430 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00079
                TEEEEEE--GGGTTSS.........SS---E............EEEEE-.....GGGTTS-EEEEEEETTEEEE CS
        RCC1  2 GrVysWGrndyGqLGl.........gttesv............lvPtkv.....eglsgnrvvkvacGddhtva 49
                ++++ +G+  +GqL l              +             +P k+     +  +g+ +v+++ G+ +t+ 
  EFC38157.1 14 DNILVCGSTGHGQLALfphqmtqikE----EgiidqqtgglfdYIPIKLeklliSYNEGEQIVDIVVGATFTLY 83
                57889999********7665443320....133443467767666*77754333555555************97 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 1.2e-05
                 EEE-GGGTTS....-EEEEEEETTEEEEE CS
        RCC1  26 Ptkveglsgn....rvvkvacGddhtval 50 
                 P++++gl+g      v +++cG+ h+++l
  EFC38157.1 122 PVRISGLEGVngliFVRQITCGAKHCAFL 150
                 9*******99****************986 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 1.2e-05
                 EEEEEE--GGGTTSSSS---E.EEEEE-GG CS
        RCC1   3 rVysWGrndyGqLGlgttesv.lvPtkveg 31 
                  Vy  G+n++Gq G gt++   + P+k+e 
  EFC38157.1 155 CVYVVGSNEMGQIGMGTSNPFmSFPQKLEI 184
                 69*************999666444666643 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.026
                 TTEEEEEE--GGGT CS
        RCC1   1 dGrVysWGrndyGq 14 
                 dG Vy+ G n+y q
  EFC38157.1 241 DGFVYASGDNEYQQ 254
                 89**********99 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.0062
                 EE--GGGTTSSSS-.--EEEEEE-GG CS
        RCC1   7 WGrndyGqLGlgtt.esvlvPtkveg 31 
                  G n +G LG +++ e+v  P+ ++ 
  EFC38157.1 396 IGYNKFGNLGFKSNeETVKAPQAIPK 421
                 699**********9677788998864 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1     0.076   4.5e+02      13      30 .]       9      26 ..       7      26 .. 0.85
   2 ?   -0.8   0.1      0.25   1.5e+03       1      16 [.      71      86 ..      71      91 .. 0.90
   3 !   20.8   0.5     4e-08   0.00024       1      30 []     137     166 ..     137     166 .. 0.98
   4 !    3.8   0.0     0.009        54       2      30 .]     226     254 ..     225     254 .. 0.82
   5 !    3.9   0.0    0.0084        50       8      21 ..     290     303 ..     290     305 .. 0.89
   6 ?    0.5   0.1     0.091   5.5e+02       5      17 ..     374     386 ..     372     386 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.076
      RCC1_2 13 aLtedGeVlcWGsNsdGQ 30
                 +t ++++l +Gs ++GQ
  EFC38157.1  9 LVTQEDNILVCGSTGHGQ 26
                5688899******99999 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.25
      RCC1_2  1 VksvsaGdyHscaLte 16
                ++++  G+ +++ L++
  EFC38157.1 71 IVDIVVGATFTLYLSS 86
                799*********9976 PP

  == domain 3  score: 20.8 bits;  conditional E-value: 4e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V+++ +G+ H  +L++++ V+  GsN+ GQ
  EFC38157.1 137 VRQITCGAKHCAFLLSNNCVYVVGSNEMGQ 166
                 89***************************9 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.009
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +++ + ++ ++  t+dG V++ G+N++ Q
  EFC38157.1 226 TKIKCSYDNTVLQTADGFVYASGDNEYQQ 254
                 567777888888899999*******9876 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.0084
      RCC1_2   8 dyHscaLtedGeVl 21 
                 d++ +aLt++G+++
  EFC38157.1 290 DSFMLALTNEGRLF 303
                 6899********96 PP

  == domain 6  score: 0.5 bits;  conditional E-value: 0.091
      RCC1_2   5 saGdyHscaLted 17 
                  +G+yH +++++d
  EFC38157.1 374 GSGRYHVVSISTD 386
                 58****9999865 PP

>> Treacle  Treacher Collins syndrome protein Treacle
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.4   2.6e-05      0.15     387     413 ..     192     218 ..     164     240 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 2.6e-05
     Treacle 387 qedSeSsEEeSdseeeavtPAqvkasv 413
                 +++S+SsEE+S++e e+  P q k + 
  EFC38157.1 192 KHQSSSSEEDSEDELEVPEPMQKKRKF 218
                 344555555555555555555554443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (536 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       882  (0.049194); expected 358.6 (0.02)
Passed bias filter:                      589  (0.0328518); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 3412.99
//
Query:       EFC38158.1  [L=443]
Description: hypothetical protein NAEGRDRAFT_59573 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   9.2e-104  347.6   0.0   1.1e-103  347.4   0.0    1.0  1  DUF1343   Protein of unknown function (DUF1343)


Domain annotation for each model (and alignments):
>> DUF1343  Protein of unknown function (DUF1343)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  347.4   0.0  5.9e-108  1.1e-103       1     353 []      43     442 ..      43     442 .. 0.89

  Alignments for each domain:
  == domain 1  score: 347.4 bits;  conditional E-value: 5.9e-108
                 EEEEE-TT-EETTTE.EHHHHHHHTT...T-EEEEEEESTT-TTS-----------B-TTT--BEEE-SGGGS...S--HHHHTT-SEEEEE----SBT CS
     DUF1343   1 vglltnqtgvdsege.hlvdvLleak...kvklvalfapeHGlrgeadagekvkdsvdpktglpvisLYgkkk...kptkemLedlDvlvfdiqDvGvR 92 
                 +gl+tn++g++ + + +++d+L+e +    ++lvalfapeHG++g++  g+ ++d++dp+t+lpv+sLY++++   +p + mL+++++lv diqDvG+R
  EFC38158.1  43 IGLITNPSGQNYQLSqSTIDLLMELTkqgYLNLVALFAPEHGIYGDKPPGQFFNDYIDPYTKLPVYSLYSETNpthEPLPYMLKNVTMLVSDIQDVGMR 141
                 8**********8876156699998863446***************************************9888888*********************** PP

                 TSTHHHHHHHHHHHHHHTT-EEEEE----TTTTS--BS----GGG-BTTB-SSS-SB----HHHHHHHHHHTT-S....EEEEE--BS--TT--..... CS
     DUF1343  93 fYTYistlayvmeaaaengieliVLDRpNplgglkveGpvldkklesfvgalpipvrhGlTiGElAklingekll....dltvipmkgwkrsml..... 182
                  +T+ist+++ +  a++n+i+++VLDR+N+l+g+ + Gp+l++k++sf+g++++p+++G+T+GElA l+++e+++    dlt+ip+ + + +++     
  EFC38158.1 142 PFTFISTMCEGLIGAKKNSIKFTVLDRINYLNGNIIAGPILNMKYKSFIGIYKLPIVTGMTMGELALLFDKEMYInldnDLTIIPIVDDSSQTYgkyrp 240
                 ************************************************************************999*************99996655555 PP

                 .HHHH-......-S-S-SSTT--SCCHHHHHHHHHHHHC.TSSB-STTSSSTTSEEEETT-SHHHHHHHHHTT.......--TTEEE.ECEEE--SSST CS
     DUF1343 183 .ydetg......lpwvkPSPnlptleaallYpglclfEg.tnvseGrGttrpFeviGapwldakklaeelnal.......klpgvkf.rpvsftptesk 265
                  ++e++      + +++PSPnlpt+e++ lY+g++lfE+  n+s+GrGtt+pF+viG+p++d++k+++ l+++        ++ v++  p++f+p+ + 
  EFC38158.1 241 sFREIRqvfrqpILYLPPSPNLPTIESVELYSGMVLFESlFNISIGRGTTNPFQVIGSPFIDSRKWMSFLQQEfatelslYFKYVQLsYPTYFIPSLDI 339
                 533333333333669************************88*******************************999988775566665269********* PP

                 TTTS-EEEEEEC........ES-TTT-.--.TCHHCCHCHHHHHHHHGG.SHHH..HHHHHHTSTHHHHHHH.CCS-CHHCHHHCHCCHHHHHH.HHHC CS
     DUF1343 266 hkgetceGvqle........vtdrekf.dp.velgllllkallelypeq.felk..afdkllgteelreqie.agksveeiraswqkelekFkk.krkk 349
                 h++  ceG++l         +t+ e++ ++ + l+l+l+k ll+ly ++ + ++  ++++l+g+ee+++qi  ++ +v ei++sw+k+l kF+k  r+k
  EFC38158.1 340 HQNAPCEGIRLVlkpldynnITNIEEYyRSfLPLSLTLMKSLLKLYGKElLIWRtdFAHILIGSEETISQILdNSVTVGEIVNSWNKDLVKFDKnVRQK 438
                 ************9999988856655541331467899*********98864566889*************987999****************98689** PP

                 C--S CS
     DUF1343 350 yllY 353
                 yl+Y
  EFC38158.1 439 YLIY 442
                 ***9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       328  (0.0182944); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 2640.90
//
Query:       EFC38159.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   6.1e-155  515.6   0.0   6.9e-155  515.5   0.0    1.0  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    9.1e-71  238.1   0.0    1.1e-70  237.8   0.0    1.1  1  Epimerase        NAD dependent epimerase/dehydratase family
    0.00062   19.0   0.0     0.0009   18.4   0.0    1.2  1  RmlD_sub_bind    RmlD substrate binding domain
  ------ inclusion threshold ------
      0.012   14.7   0.0      0.018   14.2   0.0    1.2  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
       0.13   12.1   0.0       0.23   11.3   0.0    1.5  1  NAD_binding_10   NAD(P)H-binding


Domain annotation for each model (and alignments):
>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  515.5   0.0  1.9e-158  6.9e-155       1     332 []      23     353 ..      23     353 .. 0.98

  Alignments for each domain:
  == domain 1  score: 515.5 bits;  conditional E-value: 1.9e-158
                    EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHTTSHH CS
  GDP_Man_Dehyd   1 LiTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevqpdevynLAAqshVdvsfekPe 96 
                    Li G++G++GsylaelLl+kgy+v+g++rrsssfntgr+ehl+kd +  ++ ++kl++gDltD+ ++++++++++pde+ynL+AqshV+ sfe+Pe
     EFC38159.1  23 LISGVTGQDGSYLAELLLDKGYTVYGMIRRSSSFNTGRVEHLYKDVHI-VDAKFKLVYGDLTDTGNIISIISKIRPDEIYNLGAQSHVKISFEMPE 117
                    8********************************************986.689******************************************** PP

                    HHHHHHTHHHHHHHHHHHHCT..TTSEEEEEEEGGGG-S-SSSSB-TTS-----SHHHHHHHHHHHHHHHHHHHH---EEEEEE-EEESTTS-TTS CS
  GDP_Man_Dehyd  97 ytaevnvlGtlrLLeairalglekkvrfyqaStsEvYGkvqevpqtEttpfyPrsPYaaaKlyadwivvnyreayglfavngilfnhesprrgetf 192
                    yta+v+++Gtlr Leaira+gle+k+rfyqaStsE+YG vqe+pq+EttpfyPrsPYa+aKly++wiv+nyreay++fa+ngilfnhes rrg+tf
     EFC38159.1 118 YTANVDGIGTLRFLEAIRACGLETKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYACAKLYSYWIVINYREAYNMFALNGILFNHESIRRGPTF 213
                    ************************************************************************************************ PP

                    CCCHHHHHHHHHHTTS-C-EECTTTT-EEEEEEHHHHHHHHHHHHHCSS---EEE-TT-EEECHHCHHCCHHCCCHHHHHH............TTG CS
  GDP_Man_Dehyd 193 vtrkitravarialgkqevlylGnldakRdwghvkDyveamwlmlqqdkpedyviatgethsvrefvelaflelgktiewegkgeeevgrakesgk 288
                    vtrkit avari+lg+qe+lylGnlda Rdwgh+kDyveamwlmlqq+kp+dy++atge+h+vrefve++f+ lgk++ew+gk+ +  +  +  g 
     EFC38159.1 214 VTRKITMAVARIHLGLQECLYLGNLDAERDWGHAKDYVEAMWLMLQQEKPSDYCVATGEKHKVREFVEKSFAVLGKKVEWKGKSGTVDEYGEVDGA 309
                    **********************************************************************************98877777788999 PP

                    GCCCEECGG--SS--SB--B-THHHHHHH----SS-HHHHHHHH CS
  GDP_Man_Dehyd 289 vvvevdpkyfrpgevdlllgdaskakeeLgWkpkvsfeelvrem 332
                    v+++vdp+yfrp+ev+ll+gd++ka++eLgWk kvsfeelv+ m
     EFC38159.1 310 VRIRVDPRYFRPTEVELLIGDPTKAETELGWKRKVSFEELVKGM 353
                    *****************************************976 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  237.8   0.0   3.2e-74   1.1e-70       1     239 [.      22     267 ..      22     269 .. 0.98

  Alignments for each domain:
  == domain 1  score: 237.8 bits;  conditional E-value: 3.2e-74
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC...........EEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHHHSHHHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl...........elveldltdrsalerlfkeeqpdavihlAavggvaassedpadfi 88 
                 +l+ G+tG++Gs+l++ ll+kgy+v g+ r+ss++nt+r e+l           +lv++dltd  ++  ++++ +pd++++l+a+++v+ s+e p++++
  EFC38159.1  22 ALISGVTGQDGSYLAELLLDKGYTVYGMIRRSSSFNTGRVEHLykdvhivdakfKLVYGDLTDTGNIISIISKIRPDEIYNLGAQSHVKISFEMPEYTA 120
                 599************************************************************************************************ PP

                 HHHTHHHHHHHHHHHHHTCT...EEEEEEEGGGGTSCSSSSBSTCSTTS----SSHHHHHHHHHHHHHHHHHHHHT-EEEEEEESEEESTTS-TTSTTS CS
   Epimerase  89 eknlqgtlnlleaarkagvk...rllflsSsevYGkdaeqpkeettltgplkpnspYaaaKlageklveayaaqyglnaiilrlfnlyGprngegevsr 184
                 + + +gtl+ lea+r++g++   r++++s+se+YG ++e+p++ett   p++p+spYa+aKl+++++v +y+++y+++a++++lfn+++ r+g+++v+r
  EFC38159.1 121 NVDGIGTLRFLEAIRACGLEtktRFYQASTSELYGLVQEIPQKETT---PFYPRSPYACAKLYSYWIVINYREAYNMFALNGILFNHESIRRGPTFVTR 216
                 *****************999999***********************...************************************************** PP

                 HHHHHHHHHHTTSSSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT-STTEEEE CS
   Epimerase 185 vipalirkilegkqevtllgdgtalRdflyveDvaeaillvlehvdagdkgeiyn 239
                 +i+ ++++i++g qe+++lg+++a Rd+++++D++ea++l+l++    +k+ +y 
  EFC38159.1 217 KITMAVARIHLGLQECLYLGNLDAERDWGHAKDYVEAMWLMLQQ----EKPSDYC 267
                 *******************************************9....5666665 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   2.5e-07    0.0009       4     132 ..      23     181 ..      20     206 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 2.5e-07
                    EEESTTSHHHHHHHHHCTTTSEEEEEE-TT..........................T--TTSHHHHHHHHHHH--SEEEE------HHHHHHSHHH CS
  RmlD_sub_bind   4 lvtGanGqlGseLakqlaeeglevlaltre..........................eldltdaeavaellkeakpdvvvnaAAytavDkaEseeea 73 
                    l+ G +Gq Gs La++l  +g+ v+++ r+                            dltd  ++ +++++++pd ++n++A   v    + +e 
     EFC38159.1  23 LISGVTGQDGSYLAELLLDKGYTVYGMIRRsssfntgrvehlykdvhivdakfklvYGDLTDTGNIISIISKIRPDEIYNLGAQSHVKISFEMPEY 118
                    899************************7777**********************99999********************************999**9 PP

                    HHHHHTHHHHHHHHHHHHCT....-EEEEEEEGGGS-S-TTS-B-TTS----SSHHHHHHHHH CS
  RmlD_sub_bind  74 ayavnaeavealAeaaaavg....alLihvStDyVFdGekkrpYeeddetsPlnvYGrtKlaG 132
                     ++v+  ++ +  ea +a+g      + + St   +   ++ p +e+ +  P++ Y+ +Kl  
     EFC38159.1 119 TANVDGIGTLRFLEAIRACGletkTRFYQASTSELYGLVQEIPQKETTPFYPRSPYACAKLYS 181
                    999*99999888887776662211579999***9999999999999*9******999999865 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   4.9e-06     0.018       2     121 ..      23     140 ..      22     150 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 4.9e-06
                      EEETTTSHHHHHHHHHHHHHB-SEEEEEES.-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT..T-SEEEE------HHHHH CS
  Polysacc_synt_2   2 lvtGagGsiGselvrqilkkkpkkiiller.dElklyeiekeleeelkkkklkveivpvigdvrdkerlekaleelkvdvvfhaAAlKhVPlve 94 
                      l++G +G  Gs l + +l+k  +   ++ r + ++  ++e+ + ++++  +   ++  v gd++d+ ++ ++++++++d +++  A  hV +  
       EFC38159.1  23 LISGVTGQDGSYLAELLLDKGYTVYGMIRRsSSFNTGRVEHLY-KDVHIVDA--KFKLVYGDLTDTGNIISIISKIRPDEIYNLGAQSHVKISF 113
                      799999999**9*999999987777666651556777777754.55555444..455899********************************99 PP

                      HSHHHHHHHHHHHHHHHHHHHHHTT-S CS
  Polysacc_synt_2  95 enpleaiktNvlgtenvieaaieagvk 121
                      e p  + +   +gt   +ea  ++g +
       EFC38159.1 114 EMPEYTANVDGIGTLRFLEAIRACGLE 140
                      999999999999999999999988876 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   6.5e-05      0.23       1      55 [.      26      89 ..      26     155 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6.5e-05
                    TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCH...........HHHCTTTCEEEE--TT-CCHHH CS
  NAD_binding_10  1 GAtGkvGrllvkellargghevtalvRnpekla...........eleaeeglevvegdvtdvedla 55
                    G tG+ G++l++ ll++ g++v  ++R++++++           ++  +++ ++v gd+td+  + 
      EFC38159.1 26 GVTGQDGSYLAELLLDK-GYTVYGMIRRSSSFNtgrvehlykdvHI-VDAKFKLVYGDLTDTGNII 89
                    789**************.5*********999985545444442222.3456666677777666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       307  (0.0171231); expected 358.6 (0.02)
Passed bias filter:                      291  (0.0162307); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.41u 0.20s 00:00:00.61 Elapsed: 00:00:00.35
# Mc/sec: 3139.39
//
Query:       EFC38160.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00044   20.5   4.5    0.00085   19.6   4.5    1.5  1  IMCp       Inner membrane complex protein
  ------ inclusion threshold ------
      0.024   15.0   0.2      0.082   13.3   0.2    1.9  1  FtsH_ext   FtsH Extracellular
      0.065   13.3   0.6       0.11   12.6   0.6    1.3  1  Gti1_Pac2  Gti1/Pac2 family


Domain annotation for each model (and alignments):
>> IMCp  Inner membrane complex protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   4.5   1.4e-07   0.00085       5      39 ..      43      77 ..      39      84 .. 0.85

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 1.4e-07
        IMCp  5 qekikevpkviikykekivevPevkyvdkiVeVPv 39
                + +  + pkvi k+ ek++e+P +k+v+ki+e P 
  EFC38160.1 43 EQTSSQEPKVIEKIIEKTIEIPLEKIVEKIIEKPC 77
                5566789*************************996 PP

>> FtsH_ext  FtsH Extracellular
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.2   1.4e-05     0.082       5      53 ..       9     108 ..       5     138 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.4e-05
    FtsH_ext   5 lllallllllllslfg......gsgtg................................................stkeisyseFledleqgnvekvvv 49 
                 ++ +l++++++l++++                                                           +t++ + s+F + l++++ +++++
  EFC38160.1   9 VVSILIIGVIFLYYSNlsrndnQ---AnnvvistkvreqtssqepkviekiiektieiplekivekiiekpcatsQTNDDNLSKFSQLLKNDQLKSIEL 104
                 44444444444444444445540...1456666666666677788999999999999999999999999999999***********************9 PP

    FtsH_ext  50 qest 53 
                   + 
  EFC38160.1 105 TKQI 108
                 9333 PP

>> Gti1_Pac2  Gti1/Pac2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.6   1.9e-05      0.11      72     177 ..      18     121 ..      14     123 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.9e-05
                 TEEEEEB-------------------------------.................----------------------------------EEEEEEEEEE CS
   Gti1_Pac2  72 nfLvYreldkkrakkkkkkkkkkskestkkeesksekasssssesseakessssseskasksskslekdserslvgsltdsykfkkdgLvKkTisvtlk 170
                  fL Y +l++++++ ++   ++k +e+t+++e k  +  +  +++ e+  ++  ++  ++  ++s+++d + s  ++l ++ ++k+ +L K+ +s ++k
  EFC38160.1  18 IFLYYSNLSRNDNQANNVVISTKVREQTSSQEPKVIE--KIIEKTIEIPLEKIVEKIIEKPCATSQTNDDNLSKFSQLLKNDQLKSIELTKQILSGNVK 114
                 59******99999988888777777766666554444..33333334455555553447777777888888888889********************** PP

                 TTTEEEE CS
   Gti1_Pac2 171 gkelhli 177
                 + ++hl+
  EFC38160.1 115 NPAVHLV 121
                 ******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       908  (0.0506442); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 2180.25
//
Query:       EFC38161.1  [L=1241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.6e-92  308.3   7.3    7.6e-92  308.3   7.3    2.6  2  DUF3591    Protein of unknown function (DUF3591)
  ------ inclusion threshold ------
       0.41   10.8   6.0       0.68   10.0   2.9    3.0  3  ddrB-ParB  ddrB-like ParB superfamily domain


Domain annotation for each model (and alignments):
>> DUF3591  Protein of unknown function (DUF3591)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  308.3   7.3   8.4e-96   7.6e-92       1     361 [.     455     836 ..     455     909 .. 0.89
   2 ?   -1.9   5.0      0.11     1e+03     375     435 ..    1117    1176 ..    1054    1190 .. 0.68

  Alignments for each domain:
  == domain 1  score: 308.3 bits;  conditional E-value: 8.4e-96
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.............xxxxxxxxxxxxxxxxxxxxxxx RF
     DUF3591   1 fnlsnDkaYealkenkqskvrstlgnlkveHSlpAlkLqlpfyktklskkelrsfHrprlkvk.............kkakgkeekellkktkDLslkdt 86 
                 +n+snD++Ye ++ + q + + t  + +v+HS pAlkL  ++y+  +  +elr+ H+ + k+k             k++k++++++ ++k++DLs++d 
  EFC38161.1 455 YNISNDSKYEGQTIKDQ-SQKTTAKKYTVRHSQPALKLDPKLYRSYIPDNELRRHHHRKNKFKnneimtvvfrkpkKEKKKSKKRKDIEKKQDLSAND- 551
                 8*********9977654.457888888********************************99999**********9658888889999***********. PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
     DUF3591  87 skvvllEYseeyPpllsnvGMgsklinYYrkkkekDtsrpklelGetvvlepedksPFlnlGevepgetvqtlennliraPifkhkvkstDFLlirstt 185
                  +v+l+EY ee+P ll+nvGMg+ ++nYY+k ++  +s+p++e G + v+e+ed  P   + ++  ge+++t enn++ra ifk++vkstDFLl   + 
  EFC38161.1 552 HRVILMEYVEERPSLLNNVGMGTMIMNYYKKPNSAFDSVPECEDGIPIVVESEDGVPL--INTLVDGEFFTTTENNMFRAQIFKQEVKSTDFLLCTRKA 648
                 **********************************999*********************..99*******************************988877 PP

                 .xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
     DUF3591 186 .kekkkyylreidnlfvvGqtlPlveVpgphsrkvtnfsknrLkviiyrllrkske...kr..ikvedikkafpdqselqiRkrLkefaeyqrkgedsg 278
                  + k+k+y+rei++ +vvG+t P+veV+ p +r  +++++nrL+++iyr +  + +   k+  ik++dik+afpd  +  iR+rLk  a+y+r g+  g
  EFC38161.1 649 sGGKTKFYIREIPREYVVGHTQPQVEVTPPRTRASESYTNNRLTLFIYRSFLDQMKkgkKQlkIKIDDIKEAFPDFPHQTIRERLKALATYDR-GS--G 744
                 79***********************************************99877665642255******************************.55..9 PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..........xxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxx RF
     DUF3591 279 vWklkeeerlpseeeirklvtPEdvcllesmqvgeqrlkdagy..........akeeeeeeedekkeesk.......leleeqlapWnttknFlaAtqg 360
                 vW+ ++++ +pseee+++lv+PE vc  esm+ g  rl+d g+            +  + ee       k       +e+e+   pW  t+nF  +++g
  EFC38161.1 745 VWTAHPSKPIPSEEELQNLVSPEMVCINESMLSGDLRLNDKGIddeasmvafeL-SFARVEE-------KyrdtirfIEREKIELPWDKTNNFHLCFKG 835
                 *******************************************88777665531.2222222.......122334459****************99987 PP

                 x RF
     DUF3591 361 k 361
                  
  EFC38161.1 836 G 836
                 4 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.11
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
     DUF3591  375 rgegfsfvrtsmKegfkkageskeeklkaeaekkgtdadlrklnvaeqqkvyeeeikkiwr 435 
                  rg    + r  +K+ f++ +++++ekl+++++kk t+ +  ++++ ++q+ +++++k+  +
  EFC38161.1 1117 RGRLQALSREFKKK-FRSDKHTASEKLNQDKKKKTTAIKNASVTTTRKQQTKQKKLKREQK 1176
                  55555555555555.8888888888887666655444444444444444433333333222 PP

>> ddrB-ParB  ddrB-like ParB superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.26   2.3e+03      57     100 ..     592     703 ..     582     713 .. 0.62
   2 ?   -2.6   0.1      0.63   5.6e+03      23      45 ..    1032    1056 ..    1013    1082 .. 0.67
   3 ?   10.0   2.9   7.6e-05      0.68      12      80 ..    1153    1218 ..    1136    1234 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.26
   ddrB-ParB  57 eaasGaPiv..................................................................gkdg.vvesGNgRtaalkaayeeg 88 
                 e ++G Piv                                                                  g+++ +ve    Rt a +  +++ 
  EFC38161.1 592 ECEDGIPIVvesedgvplintlvdgefftttennmfraqifkqevkstdfllctrkasggktkfyireipreyvvGHTQpQVEVTPPRTRASESYTNNR 690
                 567788887666655555566666666666666666666666666666666666666666666666666666666555556666666666665555554 PP

   ddrB-ParB  89 .kadaYrqelaed 100
                  +   Yr++l++ 
  EFC38161.1 691 lTLFIYRSFLDQM 703
                 4566666666665 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.63
   ddrB-ParB   23 t..aelqprdRsraaseaqieeiAa 45  
                  +  ae+++++R r++++  + ei +
  EFC38161.1 1032 EaeAETGKKKRGRKSKQPSVVEIGK 1056
                  1344667777777777777766655 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 7.6e-05
   ddrB-ParB   12 vveaddlkpsntaelqprdRsraaseaqieeiAanldperlgdsreaasGaPivgkdgvvesGNgRtaa 80  
                  + +a+ +++   ++ q+++ + + ++++ eei ++ + + ++++ ++++G+Pi+++++ + +   R+++
  EFC38161.1 1153 IKNASVTTT---RKQQTKQKKLKREQKKEEEIQKKEKRAAIIKKLDISDGTPIISDKKDKKKKKERSEG 1218
                  222222222...45799999999*******************************988877777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3134  (0.174801); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                       116  (0.00646996); expected 17.9 (0.001)
Passed Fwd filter:                        28  (0.00156172); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.44u 0.38s 00:00:01.81 Elapsed: 00:00:00.57
# Mc/sec: 6562.98
//
Query:       EFC38162.1  [L=403]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00037   19.8  17.9     0.0019   17.5  17.9    1.9  1  HAP1_N           HAP1 N-terminal conserved region
     0.0038   15.7  14.8     0.0059   15.0  14.8    1.2  1  MAD              Mitotic checkpoint protein
  ------ inclusion threshold ------
      0.021   15.4  15.6      0.039   14.6  13.9    2.3  2  HIP1_clath_bdg   Clathrin-binding domain of Huntingtin-intera
        0.2   11.4   2.7        1.7    8.5   0.0    2.6  2  DUF4535          Domain of unknown function (DUF4535)
       0.23   11.6   7.4       0.52   10.5   7.4    1.5  1  ARD              ARD/ARD' family
       0.29   11.2  18.4       0.56   10.3  18.4    1.4  1  TPR_MLP1_2       TPR/MLP1/MLP2-like protein
       0.52    9.6  14.1       0.88    8.9  14.1    1.2  1  Phlebovirus_NSM  Phlebovirus nonstructural protein NS-M
       0.94    9.8   7.8          4    7.7   0.6    3.4  3  HALZ             Homeobox associated leucine zipper
          1    8.9   9.3       0.15   11.6   5.4    1.5  2  Exonuc_VII_L     Exonuclease VII, large subunit
          2    9.1  16.5         12    6.6   1.3    3.5  3  YabA             Initiation control protein YabA
        3.7    6.7  12.0        6.2    6.0  12.0    1.3  1  TMPIT            TMPIT-like protein
        4.3    5.2   9.1          6    4.7   9.1    1.1  1  Prominin         Prominin
        4.4    6.6  11.5         52    3.1  11.7    2.0  1  DUF4407          Domain of unknown function (DUF4407)
          6    6.7  24.3        3.2    7.6   3.1    3.4  3  DivIC            Septum formation initiator
        7.1    6.9  22.8        2.4    8.4  11.4    3.4  3  THOC7            Tho complex subunit 7


Domain annotation for each model (and alignments):
>> HAP1_N  HAP1 N-terminal conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5  17.9   1.6e-06    0.0019     160     266 ..      66     176 ..      49     186 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.6e-06
      HAP1_N 160 qklvqldlLqeklreLeeeNekLre...easqLktetdtlEekEqqLvldcveqlseanqqiaelseelarkleelerqqeeiss.Llaqivdlqqklk 254
                  + +++++L++ +++L  eNe+Lr+   +  ++++e +++Ee  ++L  + +++++++++q++e++ el++++ e+er ++++ +   ++  ++++k+ 
  EFC38162.1  66 YEEPNVEILKNMIQSLRTENEQLRKpskDIDKIAREKKEIEESYRKLQVESANEVKHVRKQYDEIARELQSQTIENERLKKQVLHsNNTRNAEFEEKIL 164
                 567899******************82224456789**************************************99999999986513455555555555 PP

      HAP1_N 255 elgveneelkqh 266
                 +l++e ++ k++
  EFC38162.1 165 QLKKELKQAKAE 176
                 555554444444 PP

>> MAD  Mitotic checkpoint protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0  14.8   4.9e-06    0.0059      74     184 ..      82     189 ..      67     211 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 4.9e-06
         MAD  74 qiElarlkkknlealnkkekekesklaearevisalknelaelkrqiekqelelsekeseleelqer.ldllkkklseleqliqqlekkqkelaeaeqr 171
                 ++E+++ ++k  + ++k ++ek++ +++ r ++ +  ne++  ++q  +   el++++ e+e+l+++ l  ++++ +e+e++i ql+k+ k   +a++ 
  EFC38162.1  82 RTENEQ-LRKPSKDIDKIAREKKEIEESYRKLQVESANEVKHVRKQYDEIARELQSQTIENERLKKQvLHSNNTRNAEFEEKILQLKKELK---QAKAE 176
                 445555.67899999*************************************************977367888999999999999987655...55555 PP

         MAD 172 ikeLefeiqsqed 184
                 i  L++e++ + +
  EFC38162.1 177 IDILKVENNRYYS 189
                 6666666666544 PP

>> HIP1_clath_bdg  Clathrin-binding domain of Huntingtin-interacting protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6  13.9   3.3e-05     0.039      23      95 ..      96     169 ..      85     174 .. 0.91
   2 ?    4.7   1.1     0.038        46      42      72 ..     151     181 ..     146     187 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 3.3e-05
  HIP1_clath_bdg  23 eeverekkeleeelerlkeeaerkleeqkeelekLkreleakraelarlks.sLesseqsgeqlssqlaaLqaE 95 
                     + ++rekke+ee+ ++l+ e+ +++++ +++ +++ rel+++  e +rlk+  L+s+++ +++ ++++ +L++E
      EFC38162.1  96 DKIAREKKEIEESYRKLQVESANEVKHVRKQYDEIARELQSQTIENERLKKqVLHSNNTRNAEFEEKILQLKKE 169
                     6799*********************************************86268999999************99 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.038
  HIP1_clath_bdg  42 eaerkleeqkeelekLkreleakraelarlk 72 
                     +++ + +e +e++ +Lk+el++ +ae++ lk
      EFC38162.1 151 SNNTRNAEFEEKILQLKKELKQAKAEIDILK 181
                     455566677788889***********99876 PP

>> DUF4535  Domain of unknown function (DUF4535)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0    0.0014       1.7      11      45 .]      47      91 ..      45      91 .. 0.92
   2 ?    2.1   0.8      0.14   1.6e+02      29      44 ..      96     111 ..      92     111 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0014
     DUF4535 11 vGiYvAQNYeV...........PnvkklaakglekakeleeaykKp 45
                +G Y +Q Y+            Pnv ++ ++++++++   e+ +Kp
  EFC38162.1 47 CGRYSSQQYDCvkyplplayeePNV-EILKNMIQSLRTENEQLRKP 91
                999*******66*************.88899999999999999998 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.14
     DUF4535  29 akglekakeleeaykK 44 
                 +k  ++ ke+ee+y+K
  EFC38162.1  96 DKIAREKKEIEESYRK 111
                 6677888********9 PP

>> ARD  ARD/ARD' family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   7.4   0.00043      0.52       7      97 ..      91     179 ..      87     194 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00043
         ARD   7 dseegderlphhtspkekaeelelaklgvlrwkldaddeeeaeeeekilktkeeekkdidvevlkestpnfdeklekFfeEhlhedeeirl 97 
                 +s++ d+ + ++++++e+  +l+ +    + +++  +++e a e++++   +e+ kk++ +++ +  +++f+ek+ ++++E  +  +ei +
  EFC38162.1  91 PSKDIDKIAREKKEIEESYRKLQVESAN-EVKHVRKQYDEIARELQSQTIENERLKKQV-LHSNNTRNAEFEEKILQLKKELKQAKAEIDI 179
                 5667788899999999999999998888.889999999999999999999999999999.9***********************9999975 PP

>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3  18.4   0.00047      0.56      13     120 ..      74     185 ..      68     189 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00047
  TPR_MLP1_2  13 lkeekeeaeaklqklqedlekqaeiakeaqqkYerelvkhaedvkelqalreelnelkaeiaelkaeaesakaelees....eesweeqkeelekelse 107
                 lk+ +++++++ ++l++  +   +ia+e ++  e+   ++ e ++e++ +r++++e+  e+++ + e+e++k+++  s     ++ ee+  +l+kel++
  EFC38162.1  74 LKNMIQSLRTENEQLRKPSKDIDKIAREKKEIEESYRKLQVESANEVKHVRKQYDEIARELQSQTIENERLKKQVLHSnntrNAEFEEKILQLKKELKQ 172
                 45555555666666666555555555555555555556777888888889999999999999999999998888765511115678888889******* PP

  TPR_MLP1_2 108 lekriedlneqNk 120
                 +++ i+ l+  N+
  EFC38162.1 173 AKAEIDILKVENN 185
                 *********9997 PP

>> Phlebovirus_NSM  Phlebovirus nonstructural protein NS-M
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9  14.1   0.00074      0.88     137     242 ..      79     187 ..      72     194 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00074
  Phlebovirus_NSM 137 qlgrvdyeklkkkaeekdktisrktkesEe.diknqvl.hseieqlknelqkkRnd..ikrgqekrdakklveesmArvkdlkeelkiltdels 226
                      q+ r + e+l+k +++ dk i r+ ke Ee   k qv   +e++ ++ + +    +   +  ++ r  k++ +  + r++++ e+  +l  el+
       EFC38162.1  79 QSLRTENEQLRKPSKDIDK-IAREKKEIEEsYRKLQVEsANEVKHVRKQYDEIARElqSQTIENERLKKQVLHSNNTRNAEFEEKILQLKKELK 171
                      78899999**999998887.78999999993345577524677777777776655522234556666777888899****************** PP

  Phlebovirus_NSM 227 qikseiqilrkkikdf 242
                      q+k+ei il+  +  +
       EFC38162.1 172 QAKAEIDILKVENNRY 187
                      ********99877665 PP

>> HALZ  Homeobox associated leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.052        63      17      33 ..      74      90 ..      70      91 .. 0.78
   2 ?    7.7   0.6    0.0033         4      11      35 ..     124     148 ..     121     150 .. 0.94
   3 ?    0.2   0.4      0.78   9.3e+02      10      30 ..     166     186 ..     164     186 .. 0.76

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.052
        HALZ 17 LksdydsLkkenekLka 33
                Lk   +sL+ ene+L++
  EFC38162.1 74 LKNMIQSLRTENEQLRK 90
                67777899999999975 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0033
        HALZ  11 KasYdaLksdydsLkkenekLkael 35 
                 +++Yd  + + +s   ene+Lk+++
  EFC38162.1 124 RKQYDEIARELQSQTIENERLKKQV 148
                 79**********************9 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.78
        HALZ  10 LKasYdaLksdydsLkkenek 30 
                 LK+   + k++ d Lk en++
  EFC38162.1 166 LKKELKQAKAEIDILKVENNR 186
                 666666668999999999975 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   5.4   0.00012      0.15     166     259 ..      80     180 ..      45     210 .. 0.54
   2 ?   -2.2   0.1         2   2.4e+03     129     133 ..     289     293 ..     227     383 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00012
  Exonuc_VII_L 166 ekkqrleklasrlkspee...llerkrqrldeleerleralkkqlkkkrerleelkerl.kekleekk..erl.kklkerle.......lleekker 248
                   + +++    +++l++p++   +++r++++++e  ++l+ + ++++k+ r++++e++++l ++++e+++  +++ +   ++ +       ++ + k++
    EFC38162.1  80 SLRTE----NEQLRKPSKdidKIAREKKEIEESYRKLQVESANEVKHVRKQYDEIARELqSQTIENERlkKQVlH---SNNTrnaefeeKILQLKKE 169
                   22222....222222222222555666666666666666666666666666666665553322222221111111...1111112233333334444 PP

  Exonuc_VII_L 249 leeleekleal 259
                   l++++++++ l
    EFC38162.1 170 LKQAKAEIDIL 180
                   44444444433 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2
  Exonuc_VII_L 129 pTPta 133
                   +TPt 
    EFC38162.1 289 KTPTS 293
                   33333 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   1.3    0.0099        12      39      74 ..      79     113 ..      67     115 .. 0.71
   2 ?    3.6   7.3     0.087     1e+02      21      72 ..     117     169 ..     113     172 .. 0.75
   3 ?    4.5   1.1     0.045        53      18      47 ..     157     186 ..     149     209 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0099
                 HHHHHHHHHHHHHHXXXXXXXXXXXXXXXXXXXXXX CS
        YabA  39 aeLeleneklrerleeeekkekekkkelsegkenLa 74 
                 ++L++ene+lr+   ++ +k +++kke++e++++L+
  EFC38162.1  79 QSLRTENEQLRKPS-KDIDKIAREKKEIEESYRKLQ 113
                 67888999999888.466666677777888887775 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.087
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.XXXXXXXXXXXXXXXXXXXX CS
        YabA  21 leeleelkeelaelleenaeLeleneklrerl.eeeekkekekkkelsegken 72 
                  +e+++++++  e+  e ++ ++ene+l++++ ++++++++e ++++ + k++
  EFC38162.1 117 ANEVKHVRKQYDEIARELQSQTIENERLKKQVlHSNNTRNAEFEEKILQLKKE 169
                 67899************************998544555555555555555555 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.045
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        YabA  18 eelleeleelkeelaelleenaeLelenek 47 
                 +e+ e++ +lk+el++   e + L++en++
  EFC38162.1 157 AEFEEKILQLKKELKQAKAEIDILKVENNR 186
                 455566666777777777777777777665 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0  12.0    0.0052       6.2       4      83 ..      95     178 ..      82     191 .. 0.60

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0052
       TMPIT   4 weelekefkeleetakeyk....qkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelkerkkvlk 83 
                 ++++++e ke+ee+ ++++    ++++++ k+ +++++e+++q+ + ++lk+++ + +++ ++e ee++ +lk+elk++k+ ++
  EFC38162.1  95 IDKIAREKKEIEESYRKLQvesaNEVKHVRKQYDEIARELQSQTIENERLKKQVLHSNNTRNAEFEEKILQLKKELKQAKAEID 178
                 444444444444444333211114455566666666667777777777776666666666667888888888888888887765 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   9.1     0.005         6     626     709 ..      88     178 ..      68     184 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.005
    Prominin 626 letlaekleelanelsngk...knlkqslkneaqdlraiqqelvlplessv...kklkksvkklde.ensdlqesikkllaaveraenflk 709
                 l++ +++++++a+e ++ +   ++l+++  ne++++r+ ++e++ +l+s++   + lkk+v + ++ +n +++e+i +l +++++a+ +++
  EFC38162.1  88 LRKPSKDIDKIAREKKEIEesyRKLQVESANEVKHVRKQYDEIARELQSQTienERLKKQVLHSNNtRNAEFEEKILQLKKELKQAKAEID 178
                 444444555555444333355599**********************9998733244666555555479999***************99885 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1  11.7     0.043        52     106     172 ..     128     194 ..      72     255 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.043
     DUF4407 106 keIdaelaeeqqeeakelkeqlaaaltaelaeleaqiaalqaeidaaearldalraeaqkeldgtk.g 172
                 +eI++el+++  e+ ++lk+q+  + +++ ae e++i +l++e+++a+a++d l+ e ++ ++ ++ +
  EFC38162.1 128 DEIARELQSQTIEN-ERLKKQVLHSNNTRNAEFEEKILQLKKELKQAKAEIDILKVENNRYYSSKPsS 194
                 46666666666555.34445555557788888888888999999999999999988888888877743 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   3.4     0.028        33      26      72 ..      71     119 ..      68     120 .. 0.68
   2 ?    6.0   3.8    0.0082       9.8      17      48 ..     118     149 ..     114     157 .. 0.86
   3 ?    7.6   3.1    0.0027       3.2      19      51 ..     156     188 ..     149     193 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.028
                 HHHHHHHHHHHHHHHHHHHHHHCC-XX...XXXXXXXXXXXXXXXXXXXX CS
       DivIC  26 iaalqaelaklkaeneeLeaevkdLks...dedyieerARselglvkpgE 72 
                 ++ l++ +++l+ ene+L +  kd  +   ++  iee  R +l+    +E
  EFC38162.1  71 VEILKNMIQSLRTENEQLRKPSKDIDKiarEKKEIEESYR-KLQVESANE 119
                 5667778888888888888777776446667777777777.666665555 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0082
                 XHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
       DivIC  17 laykqlkqeiaalqaelaklkaeneeLeaevk 48 
                 + +k ++++++++ +el++++ ene+L+++v 
  EFC38162.1 118 NEVKHVRKQYDEIARELQSQTIENERLKKQVL 149
                 678899***********************995 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0027
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC-X CS
       DivIC  19 ykqlkqeiaalqaelaklkaeneeLeaevkdLk 51 
                   + +++i +l++el++ kae++ L+ e +++ 
  EFC38162.1 156 NAEFEEKILQLKKELKQAKAEIDILKVENNRYY 188
                 567899999999999999999999999988875 PP

>> THOC7  Tho complex subunit 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4  11.4     0.002       2.4      56     129 ..      71     145 ..      62     148 .. 0.75
   2 ?    2.5   3.8      0.14   1.7e+02      60      98 ..     147     184 ..     138     187 .. 0.72
   3 ?   -2.2   0.0         4   4.8e+03       7      29 ..     323     348 ..     321     368 .. 0.65

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.002
       THOC7  56 ierlqllakanerereryeaekeeieseieavreeieelka..qLeearatranrkeydelaekItsnpkpReeqe 129
                 +e l++  ++ + e e++ + +++i+ +i+  ++eiee     q e a +++  rk+yde+a++++s+  ++e ++
  EFC38162.1  71 VEILKNMIQSLRTENEQLRKPSKDID-KIAREKKEIEESYRklQVESANEVKHVRKQYDEIARELQSQTIENERLK 145
                 56677777888888888887777775.6888888888876511557899******************995555555 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.14
       THOC7  60 qllakanerereryeaekeeieseieavreeieelkaqL 98 
                 q+l+ +n    +++e++  ++++e++++++ei+ lk+++
  EFC38162.1 147 QVLH-SNNTRNAEFEEKILQLKKELKQAKAEIDILKVEN 184
                 4444.4445556678888999999999999999998876 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 4
       THOC7   7 RLlnv...eerplkrltkrllkllts 29 
                 RL  +   ++++ k++ k++  ++++
  EFC38162.1 323 RLSSSkleDKKRGKPIKKTYYDTSED 348
                 66666676888889999988884444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (403 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2676  (0.149255); expected 358.6 (0.02)
Passed bias filter:                      646  (0.036031); expected 358.6 (0.02)
Passed Vit filter:                        92  (0.00513135); expected 17.9 (0.001)
Passed Fwd filter:                        34  (0.00189637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.85u 0.35s 00:00:01.20 Elapsed: 00:00:00.54
# Mc/sec: 2258.31
//
Query:       EFC38163.1  [L=1307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.039   13.7   1.0       0.13   12.1   1.0    2.0  1  IQ          IQ calmodulin-binding motif
        0.3   11.5   4.6        2.7    8.5   0.0    3.8  3  LPP         Lipoprotein leucine-zipper


Domain annotation for each model (and alignments):
>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.0   1.5e-05      0.13       2      20 ..     700     718 ..     699     719 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.5e-05
                 HHHHHHHHHHHHHHHHHHH CS
          IQ   2 kaaikIQaawRGylaRkry 20 
                  a ++IQ+++RG + Rkr+
  EFC38163.1 700 NACVRIQSWFRGIQKRKRL 718
                 699*************996 PP

>> LPP  Lipoprotein leucine-zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1     0.047   4.2e+02       7      24 ..     261     278 ..     255     284 .. 0.83
   2 ?    8.5   0.0    0.0003       2.7       5      30 ..     542     567 ..     540     571 .. 0.88
   3 ?   -0.9   0.2      0.26   2.3e+03       9      34 ..     610     635 ..     605     638 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.047
         LPP   7 sqVsqLkskvdqlssdvn 24 
                 +++++L++ v++l++d+ 
  EFC38163.1 261 NDLNNLQESVSKLEQDIY 278
                 899999999999999986 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0003
         LPP   5 LssqVsqLkskvdqlssdvnsakaaa 30 
                 L++qVs+L+ +v+ l+s ++ +++++
  EFC38163.1 542 LTNQVSRLEFQVSDLNSAMELLREDV 567
                 899************99999988887 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.26
         LPP   9 VsqLkskvdqlssdvnsakaaaqaak 34 
                 V++L +k d+l ++ +++++ + +a+
  EFC38163.1 610 VQELTEKRDKLFDENSQTNERLINAR 635
                 89999999999999888887766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2077  (0.115846); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.96u 0.36s 00:00:01.31 Elapsed: 00:00:00.54
# Mc/sec: 7336.72
//
Query:       EFC38164.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       348  (0.0194099); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.33s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 1467.23
//
Query:       EFC38165.1  [L=162]
Description: hypothetical protein NAEGRDRAFT_74044 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.9e-21   75.9   0.5    3.3e-21   75.7   0.5    1.0  1  F5_F8_type_C  F5/8 type C domain


Domain annotation for each model (and alignments):
>> F5_F8_type_C  F5/8 type C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.7   0.5   1.8e-25   3.3e-21       2     127 .]      24     157 ..      23     157 .. 0.87

  Alignments for each domain:
  == domain 1  score: 75.7 bits;  conditional E-value: 1.8e-25
                   EEESSCSSTTTGGGGGGS.....SSTTSSEEESSSSTTEEEEEEE.EEEEEEEEEEEEECSSTTSSEEEEEEEEEESSSSSEEEEEE......ECE. CS
  F5_F8_type_C   2 itasseesgewpaaaald.....GnkntaWsssssddkqwlqvdL.gkpkkidgvvtqgrqdggnayvksykiqvsddgetWttvkd......ekv. 85 
                   +t+ss ++++++ + ++      G  +++W++++++ +qw+ + + g+   ++++ +qgr     ++v+++ ++++ dg  W++v+d      + + 
    EFC38165.1  24 VTSSSKYDDNHSVEGIVLnqvrtGGLASSWCAKENNVNQWVKIYFgGNDFYVHKISIQGRHEF-QQWVTKFGLEYTVDGIRWEKVHDgnpaayH-If 118
                   7889998888844444442555566778***9999999*******888999*********888.9***********************998744.46 PP

                   EESSSSSSSEEEEEEEEEEEEEEEEEEEEEESSSSSEEEEEE CS
  F5_F8_type_C  86 pgnsdnstpvtntfdppvkaryvrltptswnggngialraEl 127
                    gn+d +t+v++++  pv+a+ v+++p++w+g+  i++r+E+
    EFC38165.1 119 AGNNDCTTVVEQNIY-PVVAKAVKIVPLEWHGH--ISMRCEV 157
                   ***************.*****************..****996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 1000.49
//
Query:       EFC38166.1  [L=466]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-09   37.4   5.8    1.8e-09   36.8   5.8    1.2  1  Glyco_transf_18  Glycosyltransferase family 18
    2.3e-05   23.4   0.3    4.4e-05   22.5   0.3    1.5  1  Glyco_transf_54  N-Acetylglucosaminyltransferase-IV (GnT-IV) 
  ------ inclusion threshold ------
      0.072   13.2   0.1       0.15   12.2   0.1    1.4  1  Imm58            Immunity protein 58
       0.11   12.5   3.5        5.4    7.0   0.3    2.5  2  Armet            Degradation arginine-rich protein for mis-fo
       0.11   12.5   0.0       0.19   11.7   0.0    1.3  1  TerB             Tellurite resistance protein TerB


Domain annotation for each model (and alignments):
>> Glyco_transf_18  Glycosyltransferase family 18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   5.8   4.9e-13   1.8e-09     467     558 .]     373     463 ..     358     463 .. 0.90

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 4.9e-13
  Glyco_transf_18 467 lsalrvlkaeegqsCkeaCqekelvCepaffkllnkkealarlevkcestesevnhl.fPaysekereCllqsdalLfsCagseeklrrlCPC 558
                      l++l++++ e+g+ C + C +++ +C+  ff+++n+ +++ ++  +c+ + + +++   P ++   + C++ + +  f C +s ++ rrlCPC
       EFC38166.1 373 LHNLKAILCEKGENCDTCCSRNNATCDGLFFPYINRCDEMRKHYPDCKCAYELADESrSPNFDG--ELCVIGNRRSRFRCGNSYRTERRLCPC 463
                      568999*************************************999987655555443999876..89************************* PP

>> Glyco_transf_54  N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.3   1.2e-08   4.4e-05     167     243 ..     194     270 ..     159     305 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 1.2e-08
  Glyco_transf_54 167 lqleDdvvakkgfltkikkfvlakkskeWlvleFsqLgfiGKlFrsedLsllveflllFy.kdkpidwLLdhillvkv 243
                      + +eDd v  ++ l++i ++ ++ k+k+W  l Fs +g+ G +   +dL  + +++ l   +  p+dwLL+++++  v
       EFC38166.1 194 ILMEDDFVFCPNALSHIVSIFTNVKQKNWSGLRFS-FGLNGVIVLKTDLVGILKYMELSRsRSFPVDWLLEELFHKTV 270
                      679*******************************9.8********************9862678********998666 PP

>> Imm58  Immunity protein 58
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   4.1e-05      0.15       6      77 ..       9      79 ..       4      84 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 4.1e-05
       Imm58  6 kalllslavaviasilfaylwidrsisldylrqseeteissvanlekllesewkglpegevfkkleavaaks 77
                + +l+ +a ++i  i+f+ +  +rsisl+  +  ++t  + v+  e + ++    + e  v k +e+v  k 
  EFC38166.1  9 LTMLVLIASSLIGGIYFTLIKSQRSISLEIFKPKKKTFETIVQ-KEEINNQTRTIIVEKVVEKVIEKVVEKK 79
                567888999**********************999988766555.5666666666667777777778877665 PP

>> Armet  Degradation arginine-rich protein for mis-folding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.3    0.0015       5.4      60      92 ..      55      87 ..      47      91 .. 0.90
   2 ?    5.8   0.3    0.0035        12     109     129 ..     374     394 ..     368     416 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0015
       Armet 60 lsevskplsvsvPvekiCeklkkkdsqicelky 92
                +++ ++ + v+  vek+ ek+ +k++ +c+l++
  EFC38166.1 55 INNQTRTIIVEKVVEKVIEKVVEKKAHVCDLNF 87
                5778899999999******************87 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0035
       Armet 109 keLkkiledWgeeCkgCieks 129
                 ++Lk il + ge+C++C  ++
  EFC38166.1 374 HNLKAILCEKGENCDTCCSRN 394
                 78***************9876 PP

>> TerB  Tellurite resistance protein TerB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   5.4e-05      0.19      24      94 ..     111     187 ..      90     197 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.4e-05
        TerB  24 e..afalalaallaevakaDgqvsesErqafrellksrfglspeeakal....lelfeeaeeeavdleqftralkrk 94 
                 +  +++ al+  ++ v + Dg+  ++E+++ + + ++   ++ + + +l    ++ + + +++++d++++++ ++++
  EFC38166.1 111 SivDLQGALLDICVFVFNTDGESVREEITKAANVSEKVTIFTRKHQHNLytnaFHDAPKKRKQSNDFYDMIKTFNDM 187
                 36788999999**********************999988888888877611115566777888***********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (466 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       978  (0.0545485); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.55
# Mc/sec: 2573.32
//
Query:       EFC38167.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1372  (0.0765241); expected 358.6 (0.02)
Passed bias filter:                      654  (0.0364772); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.37s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 1853.16
//
Query:       EFC38168.1  [L=307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.8e-34  119.4   0.3    3.9e-34  118.9   0.3    1.2  1  Metallophos  Calcineurin-like phosphoesterase
  ------ inclusion threshold ------
      0.088   13.3   0.1       0.24   11.9   0.1    1.8  1  STPPase_N    Serine-threonine protein phosphatase N-terminal 


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.9   0.3   4.4e-38   3.9e-34       2     201 ..      45     236 ..      44     239 .. 0.91

  Alignments for each domain:
  == domain 1  score: 118.9 bits;  conditional E-value: 4.4e-38
                  EEEEEESBTBTTCCTHHHHHHHHHHHH.HHHTTESEEEEESTSSSSSHHHHHHHHH.HHHHHHHTSEEEEEC-TTS........CHHHHHHHHHHHHH CS
  Metallophos   2 rilvigDlHlalgggqlddllkllddl.lreekpdlvllaGDlvdrgdlekellel.laalvkypipvylllGNHe........gfeeellnkygylg 89 
                  +++v+gD+H     gq+ dl++l++    +++ ++l+l  GD+vdrg  + e++ l l+ +++y++++++l+GNHe        gf++e+ +kyg+  
   EFC38168.1  45 PVTVCGDIH-----GQFFDLIELFKIGgESPNTNYLFL--GDYVDRGYHSVEVVTLlLCLKLRYKNRLHMLRGNHEsrqitqvyGFYDECVRKYGS-- 133
                  799******.....**********88854446889999..*******666666666699999999******************************9.. PP

                  HHHHHHEHHHCEEETSEEEEEETTEEEEEEEESE.CEEETHHHHHHHHHHHSCHHHHCC...HHHHHHHHHHTTCSEEEEEESSESSCSSSCSCCHHH CS
  Metallophos  90 ifsepwrsdaevfnnlplaslgsgslkvlllhGg.spellvsldklgslnleleapepg...dewlkdlekrekadwvivlgHsplyrgsgylfgdea 183
                      +w++ ++vf++lpla+ +++  +++++hGg sp + +sld +++l++ +e+p +g   d++++d        ++   ++   +rg+gy+fg+++
   EFC38168.1 134 --ESVWKMLTDVFDYLPLAAEIDK--QIFCVHGGlSPSI-DSLDHIRTLDRVQEIPLDGpmcDLMWSD--------PDERSSWGISPRGAGYTFGQDV 218
                  ..6699******************..********77777.****************************........777777777779********** PP

                  HHHHHHHTTESEEEEESS CS
  Metallophos 184 ledllkkygvdlvisGHt 201
                   e +  ++++ +v ++H+
   EFC38168.1 219 SEQFNHNNDLTMVARAHQ 236
                  *****************7 PP

>> STPPase_N  Serine-threonine protein phosphatase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   2.7e-05      0.24      21      38 ..      16      33 ..       4      35 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.7e-05
   STPPase_N 21 qLseaEIrqlCakareiF 38
                +Lsea+++ +C++a+e F
  EFC38168.1 16 HLSEADVKKICSMAKEYF 33
                69**************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       559  (0.0311785); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1865.49
//
Query:       EFC38169.1  [L=604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0084   16.6   0.9      0.017   15.7   0.9    1.5  1  TipAS        TipAS antibiotic-recognition domain
  ------ inclusion threshold ------
       0.13   12.4   7.9       0.33   11.2   7.9    1.6  1  TMF_TATA_bd  TATA element modulatory factor 1 TATA binding
        6.7    5.2  10.3         16    3.9  10.3    1.6  1  FapA         Flagellar Assembly Protein A


Domain annotation for each model (and alignments):
>> TipAS  TipAS antibiotic-recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.9   2.8e-06     0.017      22      90 ..     414     475 ..     388     499 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2.8e-06
                 XXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
       TipAS  22 iaklskedweelkaelkelfaklaaalaagkdpdseeaqelaeehralieefwgecskeilaglgqmYv 90 
                   ++++ ++++l++e++e++ kl++ l++     s+e+q++++  +++++    + s+  l++l+q+Y+
  EFC38169.1 414 NYQMEQFNLQNLQTEYQEINTKLKNSLKQ---KYSKEIQNIIDFSQEVMT----PLSEMQLKTLAQLYL 475
                 457888899*****************944...46****************....6999999*****998 PP

>> TMF_TATA_bd  TATA element modulatory factor 1 TATA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   7.9   5.5e-05      0.33      20      85 ..     376     441 ..     368     447 .. 0.94

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 5.5e-05
  TMF_TATA_bd  20 eirrlEgElaslkeelerleaerdeareeivklmkeneelkelkkeleelekeleelqeryetlLe 85 
                  ++++l +  ++lk+e+e+++++++  ++   +l++++ + + ++ +l++l++e++e++++++++L+
   EFC38169.1 376 KLKELNIRREQLKQEIENISKKKSPNTASSSNLTTTTKNYQMEQFNLQNLQTEYQEINTKLKNSLK 441
                  6888999999***************************************************99985 PP

>> FapA  Flagellar Assembly Protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9  10.3    0.0027        16     344     421 ..     375     450 ..     369     469 .. 0.76

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.0027
        FapA 344 eeleeleeeleklkkkikklpklkaekqlesekkeqlkklletkeklkeeleeleeelkelkeeleskkeea.kikvnk 421
                  +l+el+ + e+lk++i+ ++k+k ++      ++ l  ++++++  + +l++l++e++e++ +l+++ +++ + ++++
  EFC38169.1 375 YKLKELNIRREQLKQEIENISKKKSPN---TASSSNLTTTTKNYQMEQFNLQNLQTEYQEINTKLKNSLKQKySKEIQN 450
                 578888999999999999999944433...5667778888888888888899999999999999998865555666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2095  (0.11685); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.49
# Mc/sec: 3704.50
//
Query:       EFC38170.1  [L=547]
Description: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   1.3e-141  471.9   2.0   1.8e-141  471.5   2.0    1.2  1  HMG-CoA_red  Hydroxymethylglutaryl-coenzyme A reductase


Domain annotation for each model (and alignments):
>> HMG-CoA_red  Hydroxymethylglutaryl-coenzyme A reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  471.5   2.0  9.9e-146  1.8e-141       1     367 []     161     545 ..     161     545 .. 0.97

  Alignments for each domain:
  == domain 1  score: 471.5 bits;  conditional E-value: 9.9e-146
                  -HHHHHHHHHH....S-HHHHHHHTT.----.HHHHHHHSSS---------EEEEEEEETTEEEEEEE---STTHHHHHHHHHHHHHHT..T-B.EEE CS
  HMG-CoA_red   1 aveeRrkllee....lteeeleelke.esld.eevadkmiEnviGyvqlPlGvagpllingkeylvPmAteEgslvAsasrgakaines..gGvkttv 90 
                  av++Rr +l++    ++e+ l++l++ ++l+ ++v+++++E+v+Gyv+lP+G++gp+ i+gk y++PmAt Eg+lvAs++rg+ka+++s  gGv++++
   EFC38170.1 161 AVKIRRMFLASkinpQDENLLDNLPYaHDLNyDQVFGACCESVVGYVPLPVGIVGPIIIDGKPYHIPMATVEGCLVASTHRGCKALSSSfeGGVNSVI 258
                  58999***988777667777777866577889******************************************************99888******* PP

                  E----EEEEEEEE.--S-HHHHHHHHHTHHHHHHHHHHCSHHCCT-EEEEEEEEE-SSEEEEEEEEE-TTC--HHHHHHHHHHHHHHHH.HHHTSEEE CS
  HMG-CoA_red  91 lkdgmtraqvvllesvedaaelkkwiekkeeleelanaaestsrggglkdievvlagrlvvlrlkvdtgDAmGaNmvnkateaaaelie.eefgeeel 187
                  l+dgmtr++vv ++++++ +elk++i++ e+++el++ ++s sr+++l +++v +agr ++lr+k++tgDAmG+Nm++kat++a+++++ e+f+++++
   EFC38170.1 259 LSDGMTRGPVVQFANTKRCNELKQFIDNPENFKELCRVFNSDSRFARLLEVKVGIAGRKAFLRFKCRTGDAMGMNMISKATQKALKFLKnEHFQDMDI 356
                  ****************************************************************************************9566****** PP

                  EEEE-S--GGGEEEEEEEEEHHHH..-SSTTHHHHHHHHHHHHHHHHHH-HHHH....HHHHHHH........HHHHHHHHHHTT--HHHHHHHHHHH CS
  HMG-CoA_red 188 lsilsNlctdkkasainaiegrgksvvaeatigeevvekilkasaealvdlnra.n.igtankGi.ggfnahaaNgiaAvflAtGqDlaaveesshai 282
                  ls+++N+ctdkk+sa+n+iegrgksvv++ati+++vv+++lk++++++v+ln++ n ig+a++G+ ggfnahaaN+++A+flAtGqD+a+++ess+++
   EFC38170.1 357 LSLSGNYCTDKKPSAMNWIEGRGKSVVVDATIPKDVVKNVLKTTVDEIVSLNISkNlIGSAMAGSvGGFNAHAANIVTAIFLATGQDAAQNVESSNCM 454
                  ************************************************************************************************** PP

                  TTSEEETTTEEEEEEEEE.----SBSHHHHH-HHHHHHHHTT---HH.........HHHHHHHHHHHHHHHHHHHHHT-----HHHHHHHH CS
  HMG-CoA_red 283 aaleevedgdlygsvtlPsleVGtvGGgtklppqaellkllgvkgak......nakeLaeiiaavgLAqelsalrALaaeglqkgHmklhr 367
                  +++e++++gdly+svt+Ps+eVGtvGGgt+l +q+++lk++gv+ga+      na++La+ +a++++A+els+++ALaa++l+++H +++r
   EFC38170.1 455 TIMEKTDNGDLYVSVTMPSIEVGTVGGGTHLDAQKTCLKIIGVAGANqenpgqNAQTLAKCVASTVMAGELSLMAALAADHLVSAHIAHNR 545
                  ****************************************************************************************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (547 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.37s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2983.38
//
Query:       EFC38171.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.5e-54  182.9   0.0    1.2e-53  182.2   0.0    1.3  1  NTP_transferase  Nucleotidyl transferase
    7.5e-13   47.7   5.2    8.3e-11   41.2   2.0    2.5  2  Hexapep          Bacterial transferase hexapeptide (six repea
    1.9e-10   41.3   0.0    2.4e-10   41.0   0.0    1.2  1  NTP_transf_3     MobA-like NTP transferase domain
    0.00014   21.5   3.1     0.0003   20.5   1.7    2.3  2  Hexapep_2        Hexapeptide repeat of succinyl-transferase
     0.0021   17.1   0.5     0.0086   15.1   0.2    2.1  3  Fucokinase       L-fucokinase
  ------ inclusion threshold ------
      0.013   16.1   0.1       0.17   12.6   0.0    2.6  3  DUF4387          Domain of unknown function (DUF4387)
       0.11   12.4   0.1       0.18   11.7   0.1    1.4  1  CTP_transf_3     Cytidylyltransferase


Domain annotation for each model (and alignments):
>> NTP_transferase  Nucleotidyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  182.2   0.0   4.8e-57   1.2e-53       1     242 [.       4     233 ..       4     239 .. 0.93

  Alignments for each domain:
  == domain 1  score: 182.2 bits;  conditional E-value: 4.8e-57
                      EEEEE--S--GGGTTCCTTSSGGGSEETTETETTHHHHHHHHHTT-SEEEEEEETTTHHHHHHHHTTSGGGTSEEEEEEESS--BGGHHHHHTH CS
  NTP_transferase   1 kavILaGGsGtRLwPLtrtlakklvpvlgkerliqatlsrlansgieeiivvltqehsflveeqlkegskfgvevlialepegkgtAdAvalaa 94 
                      ka+IL+GG+GtRL+PLt ++ak+l+++++k +++ +++++l ++g++ei++ ++++ +++++   k ++k++v++++++e+e+ gtA+++ala+
       EFC38171.1   4 KALILVGGYGTRLRPLTFSTAKPLIHFANK-PIVVHQIEALKKAGCTEIVLAVNYKPQEMIDAMKKYEEKYQVKITYSVENEPLGTAGPLALAR 96 
                      799***************************.*************************************************************** PP

                      HHHTTSSE..EEEEETTEEEESTTHHHHHHHHHTHSSTTSEEEEEEESS-CTTSEEEEEC..TTSBEEEEECS-SSHSHCSEECCSEEEEETTH CS
  NTP_transferase  95 elledeksdelvlvLggDhlikdayeeavkkaiekaakgtvtfgivpveeateyGviead..eegrverfvEKPkeakaselassGiYvfnsev 186
                      ++l  ++ +e+++vL++D+++++ + e+++ ++ +++  + t+++++v+++++yGv+ ++  ++g++e+fvEKPk+    + +++GiYvf ++v
       EFC38171.1  97 DILVADE-NEYFFVLNSDVICEYSFDELLDYHKYHGK--EGTIMVTKVDDPSKYGVVVTQdgKQGEIEKFVEKPKTFV-GDRINAGIYVFSTKV 186
                      ****999.5****************************..99****************99966777*************.99************* PP

                      HHHHHHCCHHHTTSSCHHHHHHHHHHHTTEEEEEECSTTEE-EEEXSSHHHHHHHH CS
  NTP_transferase 187 llflakdleelkrgedeitdilpkaleegkvalaflfkdaeyWsDvGtldsllean 242
                      l+ +     el  + ++i+  +   ++++++ +a++ ++   W+D+G+++++++ +
       EFC38171.1 187 LERI-----EL--RPTSIEREIFPFMARDNELYAMDLNG--FWMDIGQPKDYITGM 233
                      ****.....44..45566666667777779999******..6**********9866 PP

>> Hexapep  Bacterial transferase hexapeptide (six repeats)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.2   2.0   3.2e-14   8.3e-11       2      36 .]     267     301 ..     266     301 .. 0.94
   2 !    7.2   0.1    0.0017       4.2       2      28 ..     319     345 ..     318     347 .. 0.88

  Alignments for each domain:
  == domain 1  score: 41.2 bits;  conditional E-value: 3.2e-14
                 EEEETTEEE-TTEEEETTEEE-TTEEEETTEEEES CS
     Hexapep   2 tvIGsnvlIgpfaviggnVkIGdnvkIgagvvigg 36 
                 + +G+nv+Ig++a+ig+nV++Gdnv+I++g+++++
  EFC38171.1 267 VLVGENVKIGKGAMIGPNVVLGDNVIIEEGARVTR 301
                 679*****************************985 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0017
                 EEEETTEEE-TTEEEETTEEE-TTEEE CS
     Hexapep   2 tvIGsnvlIgpfaviggnVkIGdnvkI 28 
                 ++IG ++ +g+++ + +n+++G+++++
  EFC38171.1 319 SIIGWKSSVGKWSRVTNNTVLGEDTHV 345
                 678889999***************987 PP

>> NTP_transf_3  MobA-like NTP transferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.0   0.0   9.2e-14   2.4e-10       1     122 [.       5     138 ..       5     206 .. 0.80

  Alignments for each domain:
  == domain 1  score: 41.0 bits;  conditional E-value: 9.2e-14
                   EEEEEESS-TTTT....T.THHHHCCCCCCHHHHHHHHHCTT.-CEEEEECSH..CHHHHHHTTC....TS-E...EE-TTSS.-SHHHHHHHHHHH CS
  NTP_transf_3   1 aviLAGGrSsRmg....g.dKallplggkpllervldalraagvdevvvvggd..eevlaalarl....gvrv...vededpg.kgplaslaaalra 82 
                   a+iL GG ++R+     +  K+l+ +++kp++ ++++al++ag+ e+v+++++  +e  +a++++    +v++   ve+e+ g +gpla  +  l a
    EFC38171.1   5 ALILVGGYGTRLRpltfStAKPLIHFANKPIVVHQIEALKKAGCTEIVLAVNYkpQEMIDAMKKYeekyQVKItysVENEPLGtAGPLALARDILVA 101
                   79**********7554425*********************************954344444444322225655555667666548999999999987 PP

                   H.SSSCEEEEETT-TT--HHHHHHHHHCHHHHTSSEEEEE CS
  NTP_transf_3  83 aadadavlvlacDmPlltpelverllaaaaasgadvvvpt 122
                     ++++++vl  D+++  +   ++ll+ ++ +g++ ++ +
    EFC38171.1 102 D-ENEYFFVLNSDVIC--EYSFDELLDYHKYHGKEGTIMV 138
                   6.9***********87..8888888888877776554443 PP

>> Hexapep_2  Hexapeptide repeat of succinyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   1.7   1.2e-07    0.0003       3      33 ..     268     300 ..     266     301 .. 0.88
   2 ?   -1.7   0.0         1   2.6e+03      20      32 ..     327     339 ..     318     351 .. 0.59

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.2e-07
                 EE-TT-EE-TT-EES..EEE-TT-EE-TT-EE- CS
   Hexapep_2   3 iIGdnCliGanagiG..vslGdncvvgaGvvit 33 
                  +G+n+ iG+ a iG  v lGdn++++ G  +t
  EFC38171.1 268 LVGENVKIGKGAMIGpnVVLGDNVIIEEGARVT 300
                 589***********999*********9887766 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1
                 E-TT-EE-TT-EE CS
   Hexapep_2  20 lGdncvvgaGvvi 32 
                 +G+ + v ++ v+
  EFC38171.1 327 VGKWSRVTNNTVL 339
                 4444445555554 PP

>> Fucokinase  L-fucokinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       0.2   5.1e+02      48     117 ..     103     167 ..      91     188 .. 0.63
   2 ?   -2.6   0.0      0.78     2e+03      46      65 ..     172     192 ..     160     214 .. 0.71
   3 !   15.1   0.2   3.4e-06    0.0086     270     339 ..     281     360 ..     223     367 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.2
  Fucokinase  48 mkpGvlvtssDvlllf.dseeisfdka.gvtalavpstldigtnHGVfvlddqsseeeeleirsvkkflhKp 117
                  ++ ++v++sDv+  +  +e ++ +k  g  +  + +++d  ++ GV+v++d   ++     ++++kf+ Kp
  EFC38171.1 103 ENEYFFVLNSDVICEYsFDELLDYHKYhGKEGTIMVTKVDDPSKYGVVVTQDG--KQ-----GEIEKFVEKP 167
                 46667888888887443222233322235555555556666677788888887..33.....6777777777 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.78
  Fucokinase  46 k.rmkpGvlvtssDvlllfds 65 
                   r++ G+ v s+ vl+ ++ 
  EFC38171.1 172 GdRINAGIYVFSTKVLERIEL 192
                 546788888888888885533 PP

  == domain 3  score: 15.1 bits;  conditional E-value: 3.4e-06
  Fucokinase 270 k............kesavvinSvlessvsvgegsviehsslkgnvsigsnsivsglelesseeslelpddtilqtlslklsk 339
                 +            +e+a v+ S + +s+ v++++++++s ++ + s+g++s v +  +  +  + ++ ++++++++++  +k
  EFC38171.1 281 IgpnvvlgdnviiEEGARVTRSTIFESAWVKQHALVKSSIIGWKSSVGKWSRVTNNTVLGE--DTHVDNEIFVNEIKVLPHK 360
                 0555555555567999*******************************************98..56***********998776 PP

>> DUF4387  Domain of unknown function (DUF4387)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.55   1.4e+03      11      36 ..      44      69 ..      38      84 .. 0.75
   2 ?   12.6   0.0   6.5e-05      0.17      13      53 ..      89     129 ..      87     162 .. 0.76
   3 ?   -3.0   0.0       4.8   1.2e+04      51      71 ..     300     320 ..     291     345 .. 0.62

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.55
     DUF4387 11 KnaGpfeitlDilfkdkeaYervkes 36
                K aG  ei l + +k +e+ +++k+ 
  EFC38171.1 44 KKAGCTEIVLAVNYKPQEMIDAMKKY 69
                78888888888888888887777764 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 6.5e-05
     DUF4387  13 aGpfeitlDilfkdkeaYervkesklltkeliaklykieee 53 
                 aGp  +  Dil++d+++Y  v +s+++ +  + +l+++++ 
  EFC38171.1  89 AGPLALARDILVADENEYFFVLNSDVICEYSFDELLDYHKY 129
                 9*********************************9987653 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 4.8
     DUF4387  51 eeedivkivefdpalaiKvti 71 
                 ++++i++  ++++   +K +i
  EFC38171.1 300 TRSTIFESAWVKQHALVKSSI 320
                 444455555555555555544 PP

>> CTP_transf_3  Cytidylyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   7.2e-05      0.18      16      46 ..      25      54 ..      23      83 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7.2e-05
                  GGGSEETTEEHHHHHHHHHHHTTTTSEEEEE CS
  CTP_transf_3 16 Knlldlggkpliayvleaalkskafekviva 46
                  K+l+ +++kp++ + +ea++k++  +++++a
    EFC38171.1 25 KPLIHFANKPIVVHQIEALKKAGC-TEIVLA 54
                  9********************998.666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       608  (0.0339115); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 2187.56
//
Query:       EFC38172.1  [L=331]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.5e-45  154.0   0.0    5.9e-45  153.6   0.0    1.1  1  Epimerase        NAD dependent epimerase/dehydratase family
    2.4e-13   50.2   0.0    5.4e-13   49.0   0.0    1.5  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    5.6e-06   25.7   0.1     0.0018   17.5   0.0    2.8  4  Polysacc_synt_2  Polysaccharide biosynthesis protein
    5.8e-06   25.5   0.1    1.8e-05   23.9   0.0    1.7  2  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
    5.1e-05   22.5   0.0    0.00011   21.4   0.0    1.6  2  RmlD_sub_bind    RmlD substrate binding domain


Domain annotation for each model (and alignments):
>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.6   0.0   1.6e-48   5.9e-45       1     232 [.      17     247 ..      17     254 .. 0.95

  Alignments for each domain:
  == domain 1  score: 153.6 bits;  conditional E-value: 1.6e-48
                 EEEETTTSHHHHHHHHHHHHCT..SEEEEEES-STTTTCHHCHHCEEEE--TT-HHHHHHHHHHHT-SEEEE--S.---HHHHHHSHHHHHHHHTHHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekg..yevigldrlssasntarledlelveldltdrsalerlfkeeqpdavihlAa.vggvaassedpadfieknlqgtl 96 
                 +lVtG+tG+ G+a+ + +++ +    ++ l ++               ++dl+d sa+++lf++++p++v+hlAa vgg   +++ +  f+ +n++++ 
  EFC38172.1  17 VLVTGGTGLFGKAVEHVVKQDNlpGSWVFLGSK---------------DGDLRDLSACKALFEKYKPTYVLHLAAfVGGLFKNMNFKVSFWLDNVNMNN 100
                 79********************8777*******...............*************************************************** PP

                 HHHHHHHHHTCTEEEEEEEGGGGTSCSSSS.BSTCSTTS--.--SSHHHHHHHHHHHHHHHHHHHHT.....-EEEEEEESEEESTT.S-TTSTTSHHH CS
   Epimerase  97 nlleaarkagvkrllflsSsevYGkdaeqp.keettltgpl.kpnspYaaaKlageklveayaaqyg.....lnaiilrlfnlyGpr.ngegevsrvip 187
                 n+l+++ ++gvk+ + + S++v++++ e p +e++++ gp   +n +Ya+aK++ + l   y++q        ++ +++++nlyGp+ n++ e+ +v+p
  EFC38172.1 101 NILSCCYEYGVKKTISCLSTCVFPDKIEYPiTEDKLHVGPPhFSNDAYAYAKRMLDMLSVWYNEQAVregkeSRFSSVIPTNLYGPHdNFNVENGHVLP 199
                 ****************************9989*********99***************99999998557888*************************** PP

                 HHHHHHHTTS...SSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT- CS
   Epimerase 188 alirkilegk...qevtllgdgtalRdflyveDvaeaillvlehvdag 232
                  l+ k+++++    +++++g+g++lR+fl++ D+a+++l+ + +++++
  EFC38172.1 200 GLMHKCYKAQkggSDFIVYGSGKPLRQFLFSHDAARMLLWTMLNYQSQ 247
                 ********776777***************************9998774 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.0   0.0   1.5e-16   5.4e-13      57     261 ..      49     268 ..       9     314 .. 0.75

  Alignments for each domain:
  == domain 1  score: 49.0 bits;  conditional E-value: 1.5e-16
                    EE--TT-HHHHHHHHHHHT-SEEEE--S---.HHHHTTSHHHHHHHHTHHHHHHHHHHHHCT..TTSEEEEEEEGGGG-S-SSSSB-TT.....S- CS
  GDP_Man_Dehyd  57 hkgDltDssslerllaevqpdevynLAAqsh.VdvsfekPeytaevnvlGtlrLLeairalglekkvrfyqaStsEvYGkvqevpqtEt.....tp 146
                      gDl+D s+ + l+++++p+ v++LAA      + ++    ++  nv    ++L ++ ++g++k++     St  v+ +  e p+tE+      p
     EFC38172.1  49 KDGDLRDLSACKALFEKYKPTYVLHLAAFVGgLFKNMNFKVSFWLDNVNMNNNILSCCYEYGVKKTIS--CLST-CVFPDKIEYPITEDklhvgPP 141
                    479*************************8543677777778999999***************975444..3444.6************85444345 PP

                    ----SHHHHHHHHHHHHHHHHHHH.....H---EEEEEE-EEESTTS-TTS....CCCHHHHHHHHHHTTS-C-EECTTTT-EEEEEEHHHHHHH. CS
  GDP_Man_Dehyd 147 fyPrsPYaaaKlyadwivvnyrea.....yglfavngilfnhesprrgetf....vtrkitravarialgkqevlylGnldakRdwghvkDyvea. 232
                       +  Ya aK + d++ v y+e+      +   ++ i  n ++p+ + ++    v   +++   ++++g  + +++G +++ R +++ +D +++ 
     EFC38172.1 142 HFSNDAYAYAKRMLDMLSVWYNEQavregKESRFSSVIPTNLYGPHDNFNVenghVLPGLMHKCYKAQKGGSDFIVYGSGKPLRQFLFSHDAARMl 237
                    55699****************8874444356689999*********8766422236666777788999999***********************97 PP

                    HHHHHHCSS---EE..E-TT-EEECHHCHHC CS
  GDP_Man_Dehyd 233 mwlmlqqdkpedyv..iatgethsvrefvel 261
                    +w+ml+ +++e ++  +++ ++ s++++++ 
     EFC38172.1 238 LWTMLNYQSQEPIMlcVSEEDEKSIGQVAQS 268
                    8****88777776611455556666665543 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.0   0.2    0.0031        11       1      18 [.      17      34 ..      17      50 .. 0.81
   2 !   17.5   0.0   5.1e-07    0.0018      61     128 ..      51     120 ..      43     133 .. 0.84
   3 ?   -2.4   0.0      0.55     2e+03     138     166 ..     148     178 ..     142     186 .. 0.72
   4 ?   -3.3   0.0         1   3.7e+03      21      46 ..     247     272 ..     234     282 .. 0.72

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0031
                     EEEETTTSHHHHHHHHHH CS
  Polysacc_synt_2  1 vlvtGagGsiGselvrqi 18
                     vlvtG++G +G+++ + +
       EFC38172.1 17 VLVTGGTGLFGKAVEHVV 34
                     89*********9875544 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 5.1e-07
                      --TT-HHHHHHHTT..T-SEEEE------HHHHHHS.HHHHHHHHHHHHHHHHHHHHHTT-SEEE.EEEE CS
  Polysacc_synt_2  61 gdvrdkerlekaleelkvdvvfhaAAlKhVPlveen.pleaiktNvlgtenvieaaieagvkkvv.liSt 128
                      gd+rd + ++ ++e++k+ +v+h AA+      ++n  ++ +  Nv   +n+++++ e+gvkk + ++St
       EFC38172.1  51 GDLRDLSACKALFEKYKPTYVLHLAAFVGGLFKNMNfKVSFWLDNVNMNNNILSCCYEYGVKKTIsCLST 120
                      899***********************97666655552578999*******************98845676 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 0.55
                      HHHHHHHHHHHHHHGGG--SSS-..-EEEEE CS
  Polysacc_synt_2 138 mGatKrlaekllqalakeseekk..tkfvvv 166
                      +  +Kr+ ++l + +++++ ++   ++f+ v
       EFC38172.1 148 YAYAKRMLDMLSVWYNEQAVREGkeSRFSSV 178
                      6678999999999998887554434666655 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 1
                      HB-SEEEEEES-HHHHHHHHHH.... CS
  Polysacc_synt_2  21 kkpkkiillerdElklyeiekeleee 46 
                      ++p  + + e+dE+++ ++++++++ 
       EFC38172.1 247 QEPIMLCVSEEDEKSIGQVAQSIKDA 272
                      46667778888888888888876554 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1       0.2   7.2e+02       1      20 [.      18      36 ..      18      45 .. 0.77
   2 !   23.9   0.0     5e-09   1.8e-05      52     191 ..      51     193 ..      46     247 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.2
   3Beta_HSD  1 vvtGgaGFlGralvkeLvrl 20
                +vtGg+G  G+a v+++v+ 
  EFC38172.1 18 LVTGGTGLFGKA-VEHVVKQ 36
                69********87.4555555 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 5e-09
   3Beta_HSD  52 gDvtdkdkleealegvd..vvihlaslv.dvagklted.eimkvnvkGTrnvleacvkagvrvlvYtSsaevvgpnslgeeilngdEeleyeslhqday 146
                 gD++d +  ++  e+ +   v+hla+ v  ++++++++ ++   nv+  +n+l+ c + gv++ + + s   v+p++ + +i++ + +   ++  +day
  EFC38172.1  51 GDLRDLSACKALFEKYKptYVLHLAAFVgGLFKNMNFKvSFWLDNVNMNNNILSCCYEYGVKKTISCLST-CVFPDKIEYPITEDKLHVGPPHFSNDAY 148
                 66666666666665543225777777542466655555134445777789***************99875.68999*******888888888889**** PP

   3Beta_HSD 147 pesKalaEklvlkaNgrtlknggrlyTcaLRpagiyGegdkllvp 191
                 ++ K++ + l +  N++ +++g++    ++ p+ +yG+ d++ v+
  EFC38172.1 149 AYAKRMLDMLSVWYNEQAVREGKESRFSSVIPTNLYGPHDNFNVE 193
                 ***********************88889999********998765 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4   0.0     3e-08   0.00011       3      61 ..      17      77 ..      15     134 .. 0.92
   2 ?   -2.7   0.0       0.7   2.5e+03      10      47 ..     263     300 ..     261     304 .. 0.75

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 3e-08
                   EEEESTTSHHHHHHHHHCTTTSE..EEEEE-TTT--TTSHHHHHHHHHHH--SEEEE---- CS
  RmlD_sub_bind  3 ilvtGanGqlGseLakqlaeegl..evlaltreeldltdaeavaellkeakpdvvvnaAAy 61
                   +lvtG++G+ G+++ + +++++l  + + l++++ dl+d +a ++l+++ kp  v ++AA+
     EFC38172.1 17 VLVTGGTGLFGKAVEHVVKQDNLpgSWVFLGSKDGDLRDLSACKALFEKYKPTYVLHLAAF 77
                   79******************98744678889*****************************9 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.7
                    SHHHHHHHHHCTTTSEEEEEE-TTT--TTSHHHHHHHH CS
  RmlD_sub_bind  10 GqlGseLakqlaeeglevlaltreeldltdaeavaell 47 
                    Gq+++ ++++++ +g  +  +++++ ++++ ++ a++l
     EFC38172.1 263 GQVAQSIKDAFNFSGNMIFDTSKADGQFKKTASNAKML 300
                    88888888888888888888877777777777766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (331 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       588  (0.032796); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.57u 0.36s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2002.57
//
Query:       EFC38173.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-29  103.2   0.6    7.9e-29  100.6   0.3    2.3  2  Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransf
     0.0009   19.6   2.9     0.0043   17.4   3.1    2.1  2  DUF2681          Protein of unknown function (DUF2681)
  ------ inclusion threshold ------
      0.079   13.4   1.7        4.5    7.8   0.0    3.1  3  FucT_N           Alpha-(1,3)-fucosyltransferase FucT N-termin
       0.12   12.3   2.3       0.26   11.3   0.5    2.2  2  DUF4446          Protein of unknown function (DUF4446)
       0.43   10.7   7.0      0.097   12.8   2.7    2.2  2  ORF6C            ORF6C domain


Domain annotation for each model (and alignments):
>> Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransferase) C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.28   9.9e+02      43      80 ..     198     237 ..     174     242 .. 0.72
   2 !  100.6   0.3   2.2e-32   7.9e-29       5     163 ..     313     485 ..     309     518 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.28
  Glyco_transf_10  43 eelsekeveelikkykFYLafEns..ickDYiTeKlwnal 80 
                      e+ s k+++e+ik+y F  ++E+     +  + e lw++l
       EFC38173.1 198 EQVSVKKFQETIKSYGFLNSVEEIsnKIDSELGETLWRML 237
                      567789999********99999753223334566666655 PP

  == domain 2  score: 100.6 bits;  conditional E-value: 2.2e-32
  Glyco_transf_10   5 vawvvsncktk...skRekyvkeLkkhlevdvyGkcgklkveelsekeveelikkykFYLafEnsickDYiTeKlwnale....agavPvvlGp 91 
                       + ++snc ++   ++R +++++L+++l+v  yGkcg++   e++  ++ el++++k Y+a+Ens+  DYiTeKl++ ++     g + +v+ +
       EFC38173.1 313 LCAFISNCVAEshaTQRLQILEQLSTYLPVRQYGKCGRNA-YETNGGKMFELEHNCKIYFAMENSVVPDYITEKLYEGFKsmenGGRLLMVYKG 405
                      58899***99877789********************9888.8899999****************************666522133456666655 PP

  Glyco_transf_10  92 arenyerfvppdsfihvddFkspkelaeyLkkldkneeeYleYfeWrkkykvkkkeeleee........lCklCeklkek 163
                      + +  +   p+++fi+vddF+s++el +yLkkl++ne+e+++ f+  ++ +v+ ++ ++ +         C++C+ + ++
       EFC38173.1 406 PPNIADFKYPKSAFINVDDFSSIDELGQYLKKLNENEDEFNKRFAELERDRVQINHAIKMMrpslsnfiPCRMCKIVGQT 485
                      535555558*********************************99987777774334443334567777789999988754 PP

>> DUF2681  Protein of unknown function (DUF2681)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   3.1   1.2e-06    0.0043      10      74 ..      20      83 ..      12      89 .. 0.75
   2 ?   -3.3   0.0       3.6   1.3e+04       5      26 ..     276     297 ..     273     310 .. 0.71

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.2e-06
     DUF2681 10 liaavlllvaylswqlkkarkknaklqaekqqlkvekavaeaevknakvkqkneentrrlsrdsv 74
                ++  v ++va+l w++kk r  n+ l +e +  ++ k+++e++v      qk + +++ +  +++
  EFC38173.1 20 AAVIVFVMVAFLLWRTKKDRFSNNILIKEDETNQA-KQTIEQQVAKLTTEQKLKKQAQHSDDTKI 83
                444556678***********999999999987665.66778888888888888877777766666 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.6
     DUF2681   5 allvgliaavlllvaylswqlk 26 
                  + v ++ ++ l+  yl++ ++
  EFC38173.1 276 DVSVCFFRSCTLFNNYLYYPIN 297
                 5668889999999999998664 PP

>> FucT_N  Alpha-(1,3)-fucosyltransferase FucT N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.7     6e+03      38      64 ..     110     136 ..      82     147 .. 0.73
   2 ?    3.3   0.1     0.031   1.1e+02      16      88 ..     204     296 ..     195     299 .. 0.80
   3 ?    7.8   0.0    0.0013       4.5      17      82 ..     332     398 ..     320     403 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.7
      FucT_N  38 ysvfgeealkyekcvkifftgENitpd 64 
                 y   g++++k +   +i f  E it +
  EFC38173.1 110 YNSIGNTTFKDSYVSRIGFKNEEITSP 136
                 566677777777777777887777765 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.031
      FucT_N  16 llveilsqrfklelsdspdlllysvfgeealkyekcvkifftgENitpd...................fnlvDlaigF.dklkfedrylrlPl 88 
                 ++ e++++   l+++++    + s +ge+ ++  ++++ +  gE ++ +                    + +D+++ F    +  ++yl +P+
  EFC38173.1 204 KFQETIKSYGFLNSVEEISNKIDSELGETLWRMLRRLTFYMNGESVVRNiisgylqtkddpasmerfsSTSIDVSVCFfRSCTLFNNYLYYPI 296
                 55566666666777788888899999******9889***********9999999999999999999888899999986255677788898886 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0013
      FucT_N  17 lveilsqrfklelsdspdlllysvfgeealkyekcvkifftgEN.itpdfnlvDlaigFdklkfedr 82 
                 ++e+ls+   ++   ++  + y + g ++++ e+ +ki+f  EN ++pd+ +  l+ gF+ ++ + r
  EFC38173.1 332 ILEQLSTYLPVRQYGKCGRNAYETNGGKMFELEHNCKIYFAMENsVVPDYITEKLYEGFKSMENGGR 398
                 666777777777777788888999999999**99*********9889***99999999999987766 PP

>> DUF4446  Protein of unknown function (DUF4446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.5   7.3e-05      0.26       7      79 ..      18      91 ..      14     110 .. 0.76
   2 ?   -0.4   0.0      0.28     1e+03      49      84 ..     430     465 ..     419     468 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 7.3e-05
     DUF4446  7 avlvvillillivllvklkklkkkykklmkgkdgksleellkekleeveelkeesee.lekeieeleeklkksl 79
                +  +vi+++++ +ll+++kk + + + l+k+++ ++ +++++++++++ + ++ +++  +++ ++++++++  l
  EFC38173.1 18 TKAAVIVFVMVAFLLWRTKKDRFSNNILIKEDETNQAKQTIEQQVAKLTTEQKLKKQaQHSDDTKIYHQIADLL 91
                557899****************************************9987777665523444455555555544 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.28
     DUF4446  49 ekleeveelkeeseelekeieeleeklkkslqkvgl 84 
                 e  + +++l+e+++e +k+++ele++  +  + +++
  EFC38173.1 430 ELGQYLKKLNENEDEFNKRFAELERDRVQINHAIKM 465
                 445566777888888888888887776665555555 PP

>> ORF6C  ORF6C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   2.7   2.7e-05     0.097      25      88 ..      39     102 ..      34     111 .. 0.93
   2 ?   -2.8   0.1       1.9   6.7e+03       8      29 ..     434     455 ..     430     463 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.7e-05
       ORF6C  25 kLeenmpldesekeeiqkkvkkkvvellggkkspaykdkslrkkvfsdiyrdlkrefgVasYkd 88 
                  + +n +++e e ++ ++ ++++v++l+ ++k +  ++ s ++k++ +i   l r  gV sY+ 
  EFC38173.1  39 RFSNNILIKEDETNQAKQTIEQQVAKLTTEQKLKKQAQHSDDTKIYHQIADLLTRPSGVGSYDW 102
                 6789**********************************************************85 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.9
       ORF6C   8 alkehdekieeidervkkLeen 29 
                  lk+++e+ +e ++r ++Le++
  EFC38173.1 434 YLKKLNENEDEFNKRFAELERD 455
                 5788888888999998888853 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1455  (0.0811534); expected 358.6 (0.02)
Passed bias filter:                      696  (0.0388198); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.71u 0.35s 00:00:01.06 Elapsed: 00:00:00.53
# Mc/sec: 3166.72
//
Query:       EFC38174.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   5.7e-154  512.4   0.0   6.5e-154  512.3   0.0    1.0  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    2.6e-72  243.2   0.0    3.3e-72  242.8   0.0    1.1  1  Epimerase        NAD dependent epimerase/dehydratase family
    2.5e-05   23.5   0.0    3.6e-05   23.0   0.0    1.2  1  RmlD_sub_bind    RmlD substrate binding domain
    0.00056   19.1   0.0    0.00078   18.7   0.0    1.1  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
  ------ inclusion threshold ------
       0.11   12.3   0.0       0.23   11.3   0.0    1.6  1  NAD_binding_10   NAD(P)H-binding


Domain annotation for each model (and alignments):
>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  512.3   0.0  1.8e-157  6.5e-154       1     332 []      23     353 ..      23     353 .. 0.98

  Alignments for each domain:
  == domain 1  score: 512.3 bits;  conditional E-value: 1.8e-157
                    EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHTTSHH CS
  GDP_Man_Dehyd   1 LiTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevqpdevynLAAqshVdvsfekPe 96 
                    Li G++G++GsylaelLlekgy+v+gi+rrsssfntgr+ehl kd ++ l++++kl++gDltD+ +l++++++++pde+ynL+AqshV+vsfe+Pe
     EFC38174.1  23 LISGVTGQDGSYLAELLLEKGYTVYGIIRRSSSFNTGRVEHLCKDMHV-LSSRFKLVYGDLTDTGNLISIISKIKPDEIYNLGAQSHVKVSFEMPE 117
                    8*******************************************9986.799******************************************** PP

                    HHHHHHTHHHHHHHHHHHHCT..TTSEEEEEEEGGGG-S-SSSSB-TTS-----SHHHHHHHHHHHHHHHHHHHH---EEEEEE-EEESTTS-TTS CS
  GDP_Man_Dehyd  97 ytaevnvlGtlrLLeairalglekkvrfyqaStsEvYGkvqevpqtEttpfyPrsPYaaaKlyadwivvnyreayglfavngilfnhesprrgetf 192
                    yta+v+++Gtlr+Leaira+glekk+rfyqaStsE+YG vqe+pq+EttpfyPrsPYa+aKly++wiv+nyreay++fa+ngilfnhes rrg+tf
     EFC38174.1 118 YTANVDAVGTLRMLEAIRACGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYACAKLYSYWIVINYREAYNMFALNGILFNHESIRRGPTF 213
                    ************************************************************************************************ PP

                    CCCHHHHHHHHHHTTS-C-EECTTTT-EEEEEEHHHHHHHHHHHHHCSS---EEE-TT-EEECHHCHHCCHHCCCHHHHHH............TTG CS
  GDP_Man_Dehyd 193 vtrkitravarialgkqevlylGnldakRdwghvkDyveamwlmlqqdkpedyviatgethsvrefvelaflelgktiewegkgeeevgrakesgk 288
                    vtrkit avari+lg+q++lylGnlda Rdwgh+kDyv+amwlmlqq+kp dy++atge+h+vrefve++f+ lg+++ew+g+  +  +  +  g 
     EFC38174.1 214 VTRKITMAVARIHLGLQDCLYLGNLDAERDWGHAKDYVKAMWLMLQQEKPADYCVATGEKHKVREFVEKSFAVLGRRVEWKGTPGTVDEYGEVDGI 309
                    **********************************************************************************97666666677899 PP

                    GCCCEECGG--SS--SB--B-THHHHHHH----SS-HHHHHHHH CS
  GDP_Man_Dehyd 289 vvvevdpkyfrpgevdlllgdaskakeeLgWkpkvsfeelvrem 332
                    v+v+vdp+yfrp+ev+ll+gd++ka++eLgW+ +v+f+elv+ m
     EFC38174.1 310 VRVKVDPSYFRPTEVELLIGDPTKAETELGWNRNVGFDELVKGM 353
                    *****************************************976 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  242.8   0.0   9.2e-76   3.3e-72       1     238 [.      22     266 ..      22     269 .. 0.98

  Alignments for each domain:
  == domain 1  score: 242.8 bits;  conditional E-value: 9.2e-76
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC...........EEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHHHSHHHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl...........elveldltdrsalerlfkeeqpdavihlAavggvaassedpadfi 88 
                 +l+ G+tG++Gs+l++ llekgy+v g+ r+ss++nt+r e+l           +lv++dltd  +l  ++++ +pd++++l+a+++v++s+e p++++
  EFC38174.1  22 ALISGVTGQDGSYLAELLLEKGYTVYGIIRRSSSFNTGRVEHLckdmhvlssrfKLVYGDLTDTGNLISIISKIKPDEIYNLGAQSHVKVSFEMPEYTA 120
                 599************************************************************************************************ PP

                 HHHTHHHHHHHHHHHHHTCT...EEEEEEEGGGGTSCSSSSBSTCSTTS----SSHHHHHHHHHHHHHHHHHHHHT-EEEEEEESEEESTTS-TTSTTS CS
   Epimerase  89 eknlqgtlnlleaarkagvk...rllflsSsevYGkdaeqpkeettltgplkpnspYaaaKlageklveayaaqyglnaiilrlfnlyGprngegevsr 184
                 + +++gtl++lea+r++g++   r++++s+se+YG ++e+p++ett   p++p+spYa+aKl+++++v +y+++y+++a++++lfn+++ r+g+++v+r
  EFC38174.1 121 NVDAVGTLRMLEAIRACGLEkktRFYQASTSELYGLVQEIPQKETT---PFYPRSPYACAKLYSYWIVINYREAYNMFALNGILFNHESIRRGPTFVTR 216
                 *****************999999***********************...************************************************** PP

                 HHHHHHHHHHTTSSSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT-STTEEE CS
   Epimerase 185 vipalirkilegkqevtllgdgtalRdflyveDvaeaillvlehvdagdkgeiy 238
                 +i+ ++++i++g q++++lg+++a Rd+++++D+++a++l+l++    +k+ +y
  EFC38174.1 217 KITMAVARIHLGLQDCLYLGNLDAERDWGHAKDYVKAMWLMLQQ----EKPADY 266
                 *******************************************9....556666 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0     1e-08   3.6e-05       4     132 ..      23     181 ..      20     207 .. 0.91

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 1e-08
                    EEESTTSHHHHHHHHHCTTTSEEEEEE-TT..........................T--TTSHHHHHHHHHHH--SEEEE------HHHHHHSHHH CS
  RmlD_sub_bind   4 lvtGanGqlGseLakqlaeeglevlaltre..........................eldltdaeavaellkeakpdvvvnaAAytavDkaEseeea 73 
                    l+ G +Gq Gs La++l e+g+ v+++ r+                            dltd  ++ ++++++kpd ++n++A   v    + +e 
     EFC38174.1  23 LISGVTGQDGSYLAELLLEKGYTVYGIIRRsssfntgrvehlckdmhvlssrfklvYGDLTDTGNLISIISKIKPDEIYNLGAQSHVKVSFEMPEY 118
                    899************************7777**********************99999************************************** PP

                    HHHHHTHHHHHHHHHHHHCT-....EEEEEEEGGGS-S-TTS-B-TTS----SSHHHHHHHHH CS
  RmlD_sub_bind  74 ayavnaeavealAeaaaavga....lLihvStDyVFdGekkrpYeeddetsPlnvYGrtKlaG 132
                     ++v+a ++ ++ ea +a+g      + + St   +   ++ p +e+ +  P++ Y+ +Kl  
     EFC38174.1 119 TANVDAVGTLRMLEAIRACGLekktRFYQASTSELYGLVQEIPQKETTPFYPRSPYACAKLYS 181
                    *********99999988877522227999*******9999999*************9999865 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.0   2.2e-07   0.00078       2     122 ..      23     141 ..      22     150 .. 0.85

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 2.2e-07
                      EEETTTSHHHHHHHHHHHHHB-SEEEEEES.-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT..T-SEEEE------HHHHH CS
  Polysacc_synt_2   2 lvtGagGsiGselvrqilkkkpkkiiller.dElklyeiekeleeelkkkklkveivpvigdvrdkerlekaleelkvdvvfhaAAlKhVPlve 94 
                      l++G +G  Gs l + +l+k  +   ++ r + ++  ++e+ + ++++   l+ ++  v gd++d+ +l ++++++k+d +++  A  hV +  
       EFC38174.1  23 LISGVTGQDGSYLAELLLEKGYTVYGIIRRsSSFNTGRVEHLC-KDMHV--LSSRFKLVYGDLTDTGNLISIISKIKPDEIYNLGAQSHVKVSF 113
                      899****************977777666551567778888765.44444..455556899********************************** PP

                      HSHHHHHHHHHHHHHHHHHHHHHTT-SE CS
  Polysacc_synt_2  95 enpleaiktNvlgtenvieaaieagvkk 122
                      e p  + +   +gt  ++ea  ++g +k
       EFC38174.1 114 EMPEYTANVDAVGTLRMLEAIRACGLEK 141
                      ********************99999876 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   6.5e-05      0.23       1      61 [.      26      95 ..      26     181 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6.5e-05
                    TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCH...........HHHCTTTCEEEE--TT-CCHHHHHHTT- CS
  NAD_binding_10  1 GAtGkvGrllvkellargghevtalvRnpekla...........eleaeeglevvegdvtdvedlaealkga 61
                    G tG+ G++l++ ll++ g++v  ++R++++++           ++  +++ ++v gd+td+  l + ++ +
      EFC38174.1 26 GVTGQDGSYLAELLLEK-GYTVYGIIRRSSSFNtgrvehlckdmHVL-SSRFKLVYGDLTDTGNLISIISKI 95
                    789**************.5*********9999866666555543222.468888999999888887777755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       337  (0.0187964); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.37s 00:00:01.01 Elapsed: 00:00:00.56
# Mc/sec: 1999.10
//
Query:       EFC38175.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.1e-25   87.4   1.0    1.6e-24   86.6   1.0    1.3  1  Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransf
  ------ inclusion threshold ------
      0.042   14.2   0.0        0.1   12.9   0.0    1.6  1  TINF2_N          TERF1-interacting nuclear factor 2 N-terminu


Domain annotation for each model (and alignments):
>> Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransferase) C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.6   1.0   1.8e-28   1.6e-24       4     162 ..      74     247 ..      70     257 .. 0.80

  Alignments for each domain:
  == domain 1  score: 86.6 bits;  conditional E-value: 1.8e-28
  Glyco_transf_10   4 lvawvvsncktk..skRekyvkeLkkhlevdvyGkcgklkveelsekeveelikkykFYLafEnsickDYiTeKlw...nalea.gavPvvlGp 91 
                        + ++snc+     +R + v +L++ ++   yG+cgk+  +e s+ ++ el++++kFY afEn+  +DY+TeK++   +a+e+   v +++ +
       EFC38175.1  74 SLCSFISNCDVIdaARRIQDVLKLSTFVNGRHYGQCGKNV-AEDSRGKLYELEHNCKFYTAFENTRKEDYVTEKFFegiKAIENgAKVLMIYDG 166
                      57899****9876689999*****************9776.999999****************************9544455641468889988 PP

  Glyco_transf_10  92 arenyerf.vppdsfihvddFkspkelaeyLkkldkneeeYleYfeWrkky.kv.........kkkeeleeelCklCeklke 162
                      a +n+e+f  p+d fi+ +dF+s++el +yLk+l+++e  +++ f    +  ++         +  +++++++C++C++++e
       EFC38175.1 167 A-TNVESFgFPKDVFINRNDFSSVDELGKYLKSLSEDELLFNQTFLRAFSKqNIpiiekvfnyHYLKRTDTTVCRMCTSIAE 247
                      8.78887758****************************9999877533222122445555654445566666*****99985 PP

>> TINF2_N  TERF1-interacting nuclear factor 2 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   1.2e-05       0.1      89     128 ..     267     306 ..     257     311 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.2e-05
     TINF2_N  89 enflklvqsLledpeerekflqeefpeeYGekfdaalekL 128
                  +f + ++ Ll+++++r + l   f+  YG+ f+++l + 
  EFC38175.1 267 GEFRERMKVLLSNESNRLSILDSMFEIAYGRVFKKNLSET 306
                 5899********************************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1821.07
//
Query:       EFC38176.1  [L=1036]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.2e-39  136.3   1.9    5.3e-39  134.1   0.4    2.8  2  IPK         Inositol polyphosphate kinase
    2.8e-06   27.1   0.5    6.3e-06   25.9   0.5    1.6  1  F-box       F-box domain
    0.00023   21.0   0.2    0.00072   19.4   0.2    1.9  1  F-box-like  F-box-like
  ------ inclusion threshold ------
       0.07   12.5   0.7       0.14   11.5   0.7    1.5  1  Cas_Csy2    CRISPR-associated protein (Cas_Csy2)


Domain annotation for each model (and alignments):
>> IPK  Inositol polyphosphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.26   1.1e+03      77     116 ..     631     669 ..     618     680 .. 0.70
   2 !  134.1   0.4   1.2e-42   5.3e-39       1     197 []     835    1026 ..     835    1026 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.26
                 T-SHHHHHHHHHHCCCSSSSCCHHHHHHHCHHHHHHHHHH CS
         IPK  77 slskeevkealkkFlsngkslrkdakaaskllerLqelkq 116
                 s + ++++ a+++F+++++++r ++ + ++ ++ Lqe+ +
  EFC38176.1 631 SNNPKSLEAAITTFIEQETTRR-RSTVDKEDIAILQEIAA 669
                 5566789999******775555.45555556666777665 PP

  == domain 2  score: 134.1 bits;  conditional E-value: 1.2e-42
                  EEEEE-TTTT-SSEEEEEEEESSSSS-TTSTCHHHHHHHHHHCCSTHHHHSEEEEEEEEEE...............TTTTEEEEEEHHHHCT-SHH. CS
         IPK    1 ylvLedltagfkkPcvlDvKlGtrtydedaseekrekqqkkskettseslGfrilGmkvyk...............eeedeyltvdkkygrslske. 81  
                  +lvLedlta f++P+ lD+ +G+r y++das ek++  ++k  +  +++lGf  +Gmkvy+               +++++y+ +d+++gr ++   
  EFC38176.1  835 FLVLEDLTAPFTNPSLLDIRMGRRVYGDDASLEKIKMFEEK--YIYQKELGFGFSGMKVYNtdpefskinkskhitHKDQKYKVYDRYWGRLCKPGe 929 
                  69***************************************..********************************999999**********888766 PP

                  HHHHHHHHCCCSSSSCCHHH...HHHHCHHHHHHHHHHHHHCSHS.EEESSEEEEEEEETT......................SSEEEEEE--TTEE CS
         IPK   82 evkealkkFlsngkslrkda...kaaskllerLqelkqvlesqes.lrfyssSLLfvyegdseasekaeekeaeeeeeeeskekkvevklIDFAhvv 174 
                  e +eal  F+ + + ++++    k+++++l++L++l++++++ +  +r+yssSL++v+++d                       k+ v++IDFAhv 
  EFC38176.1  930 ESTEALDAFFFDTSYVDSEVvgiKTVKSILSQLKQLEELFKTHQLiFRVYSSSLFLVFDAD-----------------------KAIVRMIDFAHVH 1003
                  9**********99955555411155569**************9999***************.......................899********** PP

                  E--TSS--HHHHHHHHHHHHHHH CS
         IPK  175 ptesggpDegyllGlksLikile 197 
                  ++++ ++De+yl+Gl +Li+++e
  EFC38176.1 1004 ENKEPSIDENYLYGLSNLINYIE 1026
                  ********************986 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.5   1.4e-09   6.3e-06       6      43 ..      10      47 ..       8      51 .. 0.94

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 1.4e-09
                S-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHH CS
       F-box  6 LPsevlrhILerLplsdllalrrVSkgwrilidsdrlw 43
                LP ev + I+e+L+ ++l  lr V+k w++ ++s + +
  EFC38176.1 10 LPMEVKMIIFEYLSIVELNHLRIVCKEWNDTLCSSKSN 47
                9*******************************998865 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.2   1.6e-07   0.00072       3      36 ..       9      42 ..       8      54 .. 0.85

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 1.6e-07
  F-box-like  3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrrval 36
                 LP E+ + IF+yL+  +L  l+ VC+ W++  +
  EFC38176.1  9 TLPMEVKMIIFEYLSIVELNHLRIVCKEWNDTLC 42
                69****************************9774 PP

>> Cas_Csy2  CRISPR-associated protein (Cas_Csy2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.7   3.2e-05      0.14     140     222 ..     119     205 ..      88     238 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 3.2e-05
    Cas_Csy2 140 vklieleedeeekakelrrllrrllpgfalverrdllaeeleelqeeapeadaldalLdlaalnhtaekdeege.....kveWeakkk 222
                  ++ +++e+++++++e++ ++++ +  f l+ +++l++e ++++q++++e+++l   L++++++  +++ + ++     +  W+ k +
  EFC38176.1 119 SDMDSTDEEKSNEQQETNTIIEK-VTDFQLIPQKELITEDIQQIQNNSKEKTLLSRGLEASTVDNASQNIDCTRdvrsrRKFWSSKGS 205
                 55666666777777777766666.568***************************9999999887665544433333333667765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1036 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1499  (0.0836076); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.83u 0.34s 00:00:01.17 Elapsed: 00:00:00.53
# Mc/sec: 5835.76
//
Query:       EFC38177.1  [L=678]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      2e-10   40.7   0.8    2.3e-05   24.4   0.1    2.3  2  ENTH        ENTH domain
    2.9e-07   29.8   1.9    1.8e-05   23.9   0.4    2.2  2  ANTH        ANTH domain
     0.0041   17.3   0.2        4.8    7.7   0.0    3.6  3  HEAT        HEAT repeat
  ------ inclusion threshold ------
      0.051   13.6   0.1        0.1   12.6   0.1    1.4  1  SYCP2_ARLD  Synaptonemal complex 2 armadillo-repeat-like doma
      0.099   12.5   0.5       0.59   10.0   0.1    2.4  2  VHS         VHS domain
        0.1   12.6   0.1         10    6.1   0.0    2.4  2  Cnd1        non-SMC mitotic condensation complex subunit 1
       0.25   10.7   7.1        0.5    9.7   6.5    1.9  2  DUF908      Domain of Unknown Function (DUF908)


Domain annotation for each model (and alignments):
>> ENTH  ENTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.1     9e-09   2.3e-05       8     118 ..       6     116 ..       1     122 [. 0.90
   2 !   14.6   0.0     1e-05     0.026      18     120 ..     339     428 ..     323     432 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 9e-09
                 HHHHTSSSSSS--HHHHHHHHHHTTSH.HHHHHHHHHHHHHHHH--GGGHHHHHHHHHHHHHHHHHS-HHHHHHHHHTHHHHHGGGG---.B-T.TS-B CS
        ENTH   8 vreatnndpwGpsnkllteiarltysk.kelseiisvitkrLqnnkgkewrsvlKaLtlieYLlknGseqvidwlkenisiiktlsefky.ide.egkd 103
                 + +at++ +    +  + +ia+ t ++ + ++e ++ ++krL   ++k+ ++  K L +i+ + + G+ ++ + + ++ + ik++++f+   d+ +g  
  EFC38177.1   6 LTKATSETEEPTPGWMFHHIASTTKKSpQACEETTNWLMKRL---THKNPHVKKKVLLIIKSVAQSGDAEFARIIVKRSEEIKQYANFRGdKDPlHGDA 101
                 568898888888899999******9998**************...99999999************************************9999999999 PP

                 -HHHHHHHHHHHHHH CS
        ENTH 104 eglniRkkakkiisl 118
                   ++iR  a++ i+ 
  EFC38177.1 102 LNQSIRTAASQAIEA 116
                 9999***99987765 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1e-05
                 S--HHHHHHHHHHTTSHHHHHHHHHHHHHHHHH--GGGHHHHHHHHHHHHHHHHHS-HHHHHHHHHTHHHHHGGGG---B-TTS-B-HHHHHHHHHHHH CS
        ENTH  18 GpsnkllteiarltyskkelseiisvitkrLqnnkgkewrsvlKaLtlieYLlknGseqvidwlkenisiiktlsefkyideegkdeglniRkkakkii 116
                  p++k+ t+ a+   s  +l ++ + + ++L   +++ew + lKaL  ie Llk  +++v +  +en++ i + se   ++e       ++R++a+k++
  EFC38177.1 339 APTKKECTDFAQKCSS-LNLLQVAELLNQKL---DDHEWIVRLKALYGIEALLKAENKAVTEFYSENCENILKQSES--VQE-------SVRQQAEKVA 424
                 5888888899988777.88999999999999...99******************99999999998888887666555..333.......5999999999 PP

                 HHHT CS
        ENTH 117 slle 120
                 +ll+
  EFC38177.1 425 KLLN 428
                 9987 PP

>> ANTH  ANTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.4   7.1e-09   1.8e-05       7     108 ..       7     107 ..       3     110 .. 0.93
   2 !    5.1   0.0    0.0039       9.9      35      81 ..     357     401 ..     339     428 .. 0.75

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 7.1e-09
                 HHHT-SSS---HHHHHHHHHHHCST.TS-HHHHHHHHHHHCTSS.SHHHHHHHHHHHHHHHHHS-CHHHHHHHHTT-----TT---TSHHHSTHHHHHH CS
        ANTH   7 vKAtshdevPpkekhvreilvltss.rekvaalvwalsrrlkltrnwvvalKaLilvHklLreGhpsveqellsarrrisellnlssfddssskswdys 104
                  KAts+ e P      ++i ++t++ ++  +++ + l++rl+++ n  v  K+L+++  + + G+ ++ + +  ++++i++ +n+++ d+   ++++ +
  EFC38177.1   7 TKATSETEEPTPGWMFHHIASTTKKsPQACEETTNWLMKRLTHK-NPHVKKKVLLIIKSVAQSGDAEFARIIVKRSEEIKQYANFRG-DKDPLHGDALN 103
                 7*******************************************.****************************************99.66667777777 PP

                 HHHH CS
        ANTH 105 afir 108
                 + ir
  EFC38177.1 104 QSIR 107
                 7777 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0039
                 HHHHHHHHHHHCTSS.SHHHHHHHHHHHHHHHHHS-CHHHHHHHHTT CS
        ANTH  35 vaalvwalsrrlkltrnwvvalKaLilvHklLreGhpsveqellsar 81 
                 + ++++ l ++l +  +w+v lKaL  +  lL+  +++v+ e++s++
  EFC38177.1 357 LLQVAELLNQKLDDH-EWIVRLKALYGIEALLKAENKAVT-EFYSEN 401
                 557778888888888.***********************9.555544 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.05   1.3e+02       5      29 ..      43      67 ..      43      68 .. 0.86
   2 ?    1.5   0.1      0.19   4.9e+02      14      29 ..     104     119 ..     101     120 .. 0.87
   3 !    7.7   0.0    0.0019       4.8       7      29 ..     366     388 ..     361     389 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.05
                HHHHHT-SSHHHHHHHHHHHHHHHH CS
        HEAT  5 llkllsDpspeVReaAakaLgalae 29
                l+k l++++p+V + +++ +  +a+
  EFC38177.1 43 LMKRLTHKNPHVKKKVLLIIKSVAQ 67
                6899**********99998887765 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.19
                 HHHHHHHHHHHHHHHH CS
        HEAT  14 peVReaAakaLgalae 29 
                  ++R aA +a+ a+ e
  EFC38177.1 104 QSIRTAASQAIEAIFE 119
                 689********99976 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0019
                 HHHT-SSHHHHHHHHHHHHHHHH CS
        HEAT   7 kllsDpspeVReaAakaLgalae 29 
                 + l D ++ VR  A++ + al++
  EFC38177.1 366 QKLDDHEWIVRLKALYGIEALLK 388
                 3489**************99976 PP

>> SYCP2_ARLD  Synaptonemal complex 2 armadillo-repeat-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1     4e-05       0.1      23     147 ..     343     476 ..     340     482 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 4e-05
  SYCP2_ARLD  23 ekeeevsqkyskqllnkLdklinkeLdkne.......fknvsllLkciqkflkndgeeglsllikq.gLvqk.mvswfekakeflileenekneslinl 112
                 ++++++ qk+s + l ++ +l+n+ Ld++e       +  + +lLk+ +k +++  +e+ + ++kq   vq  + +  ek+ ++l + e +  +   +l
  EFC38177.1 343 KECTDFAQKCSSLNLLQVAELLNQKLDDHEwivrlkaLYGIEALLKAENKAVTEFYSENCENILKQsESVQEsVRQQAEKVAKLLNFDEGDDAQYGPTL 441
                 689999**********************994322222234666777777777775555555555541678875778899*********99999999*** PP

  SYCP2_ARLD 113 iEdffdvalviskisseGkiqlldsFllrlgalvt 147
                 +Edf  + +  s  s++  ++   +F+++ g+  t
  EFC38177.1 442 LEDFGGMSISTSSPSTSKTTRKQINFVPSSGSTTT 476
                 ****9888887776665555555578877776655 PP

>> VHS  VHS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.1   0.00023      0.59      10      78 ..       5      73 ..       2      82 .. 0.80
   2 ?   -0.7   0.1      0.45   1.2e+03      14      47 ..     393     426 ..     356     428 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00023
                HHHHHT-TT-SS-.-HHHHHHHHHHHHCSTCHHHHHHHHHHHHHT-SSHHHHHHHHHHHHHHHHHSHHHH CS
         VHS 10 liekATdeslree.dlslileicDlinekeagpkeavrlikkkinsknphvallaLklldalvkNcGskf 78
                 + kAT+e+ + +  + +   i+   +++++   e  + ++k++ +knphv    L +++++ + +  +f
  EFC38177.1  5 ILTKATSETEEPTpGW-MFHHIASTTKKSPQACEETTNWLMKRLTHKNPHVKKKVLLIIKSVAQSGDAEF 73
                5788998887655255.556899999999999********************999999999887766665 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.45
                 HT-TT-SS--HHHHHHHHHHHHCS.TCHHHHHHHH CS
         VHS  14 ATdeslreedlslileicDlinek.eagpkeavrl 47 
                 A  e+  +e+ + il+ ++ ++e+ ++++ ++++l
  EFC38177.1 393 AVTEFY-SENCENILKQSESVQESvRQQAEKVAKL 426
                 433333.3457777777777777766666666655 PP

>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0     0.004        10      15      48 ..      32      65 ..       6     125 .. 0.76
   2 ?    4.0   0.1     0.019        48      24      72 ..     362     410 ..     357     428 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.004
        Cnd1 15 vpnlveylvepLrkrLkDedpyVRktaaivvakL 48
                 p+  e++++ L krL+ ++p+V+k  ++++  +
  EFC38177.1 32 SPQACEETTNWLMKRLTHKNPHVKKKVLLIIKSV 65
                3556666777777777777777777766666555 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.019
        Cnd1  24 epLrkrLkDedpyVRktaaivvakLilndmvkekgflselaklleDenp 72 
                 e L+++L D +  VR  a++++  L++++   + +f se  + +  +++
  EFC38177.1 362 ELLNQKLDDHEWIVRLKALYGIEALLKAENKAVTEFYSENCENILKQSE 410
                 5688999999999999999999999888877777766655444444444 PP

>> DUF908  Domain of Unknown Function (DUF908)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.1   2.8e+03     310     330 ..     101     121 ..      97     134 .. 0.81
   2 ?    9.7   6.5    0.0002       0.5      90     202 ..     440     576 ..     351     593 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.1
      DUF908 310 evprelqtaaleaLealarkk 330
                 +++++++taa +a ea+ ++ 
  EFC38177.1 101 ALNQSIRTAASQAIEAIFERN 121
                 67899***********98764 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0002
      DUF908  90 klAqpfpktpvsdssakaasek...............kastteyaldlvslakedskv..lpsewgdvkvtYYkkssseeqkaesksskeeasesli.. 169
                 +l + f+  ++s+ss ++++++               +++++ +a d+ ++++++s++    + ++ ++v+ Y+ + +++++++++ + +e+++ ++  
  EFC38177.1 440 TLLEDFGGMSISTSSPSTSKTTrkqinfvpssgstttTNNNSNDASDFFDMMNDNSTSnsGDDILSGFEVKNYQPTPKQPVQQKTTRTPTETKPRVQps 538
                 567778888888877777777788899999999999988888899********9998866666667777777766666666555554444444433354 PP

      DUF908 170 ...ssspstPtplrrssklgkts..........sspsspaktstps 202
                     ss +tPt++                    + ps++++t+tp+
  EFC38177.1 539 qktPSSATTPTKSD--------LldldtllsapTIPSQKTTTTTPT 576
                 33333333333332........022223343334444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (678 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1265  (0.0705561); expected 358.6 (0.02)
Passed bias filter:                      680  (0.0379274); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.78u 0.37s 00:00:01.14 Elapsed: 00:00:00.54
# Mc/sec: 3760.06
//
Query:       EFC38178.1  [L=933]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   2.9e-165  550.1   0.0   9.3e-165  548.5   0.0    1.8  1  RNA_pol   DNA-dependent RNA polymerase
    2.4e-56  191.6   0.1    4.7e-56  190.6   0.1    1.5  1  RPOL_N    DNA-directed RNA polymerase N-terminal
  ------ inclusion threshold ------
      0.067   13.0   0.0       0.21   11.4   0.0    1.8  1  DUF3368   Domain of unknown function (DUF3368)
      0.076   13.4   2.7       0.26   11.7   2.7    1.9  1  V-SNARE   Vesicle transport v-SNARE protein N-terminus


Domain annotation for each model (and alignments):
>> RNA_pol  DNA-dependent RNA polymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  548.5   0.0  2.1e-168  9.3e-165       2     413 ..     550     932 ..     549     933 .] 0.99

  Alignments for each domain:
  == domain 1  score: 548.5 bits;  conditional E-value: 2.1e-168
                 E-HHHHHHHHHHHHHHHTT-TSSTHHHHHHHHHHTHHHHHHHHHTTT...TGGGGSSSHHHHHHHHHHHHHHHH..HGTTSEE-S-EEEEBSTHHHHHH CS
     RNA_pol   2 pLgeeglrwLkihlanlfGldkaslkervefveenleeildsaenplegkrwwlkaedpwqaLaacfelkkalesedpeeyvshlpvhqDGscnGLQHY 100
                 p+g++g+ wLkihlanl+G dk+ ++erv+fv+e ++ei+dsa++pleg+rwwlk+e+pwq+Laac+el++ l+s++pee++shlp+++DGscnGLQHY
  EFC38178.1 550 PIGKRGIFWLKIHLANLYGKDKLPFDERVQFVDEYINEIIDSADQPLEGNRWWLKSENPWQTLAACVELAECLRSPNPEEFLSHLPIQMDGSCNGLQHY 648
                 89************************************************************************************************* PP

                 HHHTT-HHHHHHTTSSSSSS---HHHHHHHHHHHHHHHHE.ESTHHHHHHHT.--HHHHHHHHHHGGGT-THHHHHHHHHHHTHHH.....TTHHHHHH CS
     RNA_pol 101 aaLgrDeegakqVNLvpsdrpqDvYsavaelvkekvekdaekgeelakllkgkikRkvvKqtvmtnvYgvtfvgareqiekqlkeleeveeeellkaas 199
                 aaLgrD+ ga +VNL+p+++p DvY +v+e+vk+++e+d+++g++lakll+g++ R ++Kqtvmt+vYgvtfvgareqi+k+lke++ev+e++++++as
  EFC38178.1 649 AALGRDNLGALHVNLLPTSKPMDVYVGVLEVVKKHIERDMKAGNKLAKLLHGNVYRSTIKQTVMTSVYGVTFVGAREQIQKRLKEKKEVPEDDVFACAS 747
                 *************************************************************************************************** PP

                 HHHHHHHHHHHTTSHHHHHHHHHHHHHHHHHHS-EB-T-.S--EEEEETTSEEEEE--EEESEEEEESSSTTE--EEEEESCEE-HHHHHHHHHHHHHH CS
     RNA_pol 200 ylaklilksleelfkgakeiqkwLkelakliakslkaeklkstvvWttplglpvvqpYrkkkkkqvktalqsvvlsksekkdpvnkrkqkqafpPNfiH 298
                 yla+ +lksl+e+f++a++i++wL+++a li++s       ++v+W+tplglpv+qpYr+k++k vkt +qs++l +s++k pv++++qk+afpPN++H
  EFC38178.1 748 YLASITLKSLGEVFSSAQNIMEWLNDCALLISSS------DTPVSWITPLGLPVIQPYRSKRSKIVKTVMQSITLADSSDKLPVSRTRQKSAFPPNYVH 840
                 *********************************5......89********************************************************* PP

                 HHHHHHHHHHHHHHHTSS--EEESSSEEEE-HHHHHHHHHHHHHHHHHHHHHTHHHHHHHHHHTTSTGGGSS....................SS----- CS
     RNA_pol 299 slDathmlltaleckeegltfaavHDsfwthaadvdelnkilreafvklhsedilerlaeefkerykkslllakvkkksevakkikavlvplelpevPk 397
                 slD++hm++ta +c++eg++faavHDsfw +a +vd++n+i+re+f++lhs+++le+l+++f++ y+                       ++++p++Pk
  EFC38178.1 841 SLDSSHMFMTASACQKEGIEFAAVHDSFWCNAGNVDRMNTIIREQFINLHSQPLLEELNATFTNLYP-----------------------QIQFPPLPK 916
                 ******************************************************************9.......................478****** PP

                 --S-SGGGGGG-TTTB CS
     RNA_pol 398 kGeldveevkeskYff 413
                 kG+ld+++v+++ Yff
  EFC38178.1 917 KGSLDLTRVLDAPYFF 932
                 ***************9 PP

>> RPOL_N  DNA-directed RNA polymerase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  190.6   0.1     1e-59   4.7e-56       1     334 [.     130     425 ..     130     427 .. 0.88

  Alignments for each domain:
  == domain 1  score: 190.6 bits;  conditional E-value: 1e-59
                 HHHHHHHHHHHHHHHHHHHHHHHHHHTTGGTHHHHHHHHHHHHHHHHHHHTSSSS--HHHH..........................HTTTS-HHHHHH CS
      RPOL_N   1 rQlrlEedsveaaverwreeaeelkkrglatslsskslnallweWyealeeaikeelekve......ksekkekkteedkdraeygpfLrllppeklAa 93 
                 +Q++lE++s++ a++r+r++ +++ +r++++ l+  + +++++eWye+l++ i+e++++v+      ks++++++t++++d+  +  +L+ +++eklA+
  EFC38178.1 130 KQKELETRSMDIAKARYRKDLKSATSRNQSACLP--PAKKIMLEWYEPLTKIIREKQDEVNfscskkKSSSTNTTTTTSQDNFAIPLYLTSISAEKLAI 226
                 5********************************9..*************************99998666666666667777777778************ PP

                 HHHHHHHHHHTSSS....-BHHHHHHHHHHHHHHHHHHHHHHHHHTTT.TTCHHHHHHHHSTSHHHHHHHHHHHHHHHSHSSSTTT-TT.......... CS
      RPOL_N  94 itilellsllstggvdkgvkvarlaisvGkaveeeyraeqlkkkekkkkkkkkkkekkvkklkkkkkeakealakekeeekeelkrekaeklaeeeeek 192
                 it++ell ++ ++   +g  v+++  ++G+a+++e+++e+lk+ +         k   + k +  ++++++  + + +                     
  EFC38178.1 227 ITLHELLASCLKER--GGSPVSSISYQIGDAIQAEINVEKLKRTN-------YFK--LIIKNQMIYHNINKISKLKLN--------------------- 293
                 **********9986..69*************************22.......222..333344455555543322222..................... PP

                 ..SSSCHHHHHHHHHHHHHHHHHHSTSEEEEE.....................ESTT-EEEEEE-HHHHHHH.HHHHHHTTS-TSS--BSS--B--SSS CS
      RPOL_N 193 eeeeWpqeirakvGavLislLletakvpvtaedpetgekvteeqPAFyhsyqykkgkkvgviklnpelvkll.kreplrdtltprhlPMlvpPkpWtsy 290
                 e   +++e  +++G++Li+l l+ta+vp   +        +e++PAF h   +++ k +gv++++++l++l+ +++ ++++l+p+hlPMlvpP+pWts 
  EFC38178.1 294 EYVTFTKEELVQLGSYLIQLALSTAHVPLISN-------PKETVPAFIHRNITRNSKIIGVVEPDDNLLHLIgREHVAQEILYPNHLPMLVPPNPWTSS 385
                 23689************************999.......46889****************************777888999****************** PP

                 BSEBSSSSSSBSEE-SS........HHHHHTB--HHHHHHHHHH CS
      RPOL_N 291 nkGGYllsptklmRtkdskeqkeylkaasergdldqvfkgLdvL 334
                   GGY+ ++  +mRt++s  q   lk+a    +l++++ gL++L
  EFC38178.1 386 TAGGYIALKVLIMRTRGSHLQAYTLKSA----ELNDLLSGLNTL 425
                 ****************************....999*******99 PP

>> DUF3368  Domain of unknown function (DUF3368)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   4.6e-05      0.21      24      44 ..     422     442 ..     421     444 .. 0.94

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4.6e-05
     DUF3368  24 ldaLiqaGfrispklyaevLr 44 
                 l+ L+++ +ri+p++y++vL+
  EFC38178.1 422 LNTLNETRWRINPTVYETVLK 442
                 789*****************7 PP

>> V-SNARE  Vesicle transport v-SNARE protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   2.7   5.8e-05      0.26      10      65 ..      97     152 ..      89     159 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.8e-05
     V-SNARE  10 sklarlsslag.eerkaalreiekkldeaeelldqMelEvrnlpsserasykaklre 65 
                  kl+r s ++   +  + + ei +++de++ ll+q elE+r+++  ++a y + l++
  EFC38178.1  97 AKLERDSRNQIqKKFEQFIGEIGQQIDEVKLLLKQKELETRSMD-IAKARYRKDLKS 152
                 56667665544245678899***********************7.677777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (933 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       787  (0.0438954); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.54
# Mc/sec: 5243.66
//
Query:       EFC38179.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.9e-68  230.2   5.2    2.6e-68  229.7   5.2    1.2  1  ATP-synt_D  ATP synthase subunit D
  ------ inclusion threshold ------
      0.011   15.9   3.4      0.012   15.8   2.7    1.4  1  GIDA_assoc  GidA associated domain
       0.21   11.5   3.6       0.44   10.4   0.1    2.4  3  AAA_31      AAA domain
       0.25   11.0   3.0       0.26   10.9   0.8    2.0  2  DUF4672     Domain of unknown function (DUF4672)
        3.3    8.2   6.6       0.66   10.4   2.1    2.2  3  Latarcin    Latarcin precursor


Domain annotation for each model (and alignments):
>> ATP-synt_D  ATP synthase subunit D
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  229.7   5.2   7.3e-72   2.6e-68       2     195 ..      17     208 ..      16     209 .. 0.95

  Alignments for each domain:
  == domain 1  score: 229.7 bits;  conditional E-value: 7.3e-72
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSTST.TSTSHHHHHHHSSS.SS-..TSS-SEEEEEEBTTSEEEEEE CS
  ATP-synt_D   2 LirlkkrlklaqrghslLkkKrdaLilefreilkelkelreeleeelkeayfslaea.faaggeediesavlesvklakvvkvelktenvaGVkvpvfe 99 
                 L ++k rl++a++g+slLkkK+daL ++fr+ilk++k+ +e + + +++ayfslaea + ag   di++av esvk a+ +kv+++t+n+aGV++pvf+
  EFC38179.1  17 LSNMKIRLQGAKKGYSLLKKKSDALNIKFRSILKDIKDQKEGMSDMFRKAYFSLAEArYNAG---DISYAVIESVKSAA-TKVKMRTDNIAGVTLPVFQ 111
                 899******************************************************88899...***********999.******************8 PP

                 E-...S.SSTSSSSSSSSTCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ATP-synt_D 100 leee.ksdstelygllrtgaqldeavealrellellvelasletslelLdeeikktnrRvNaLekvvIPrleetikyIkseLdEqereeffrlkkvk 195
                  +++ +s++  +  ++r+g+q++++++ ++e+l+ l++lasl+ts+++Ld++ik tnrRvNaLekv+ Pr+++ti+yI seLdE ereeffrlkk++
  EFC38179.1 112 QDDSsQSEEGMTSMISRGGEQIQNCKSIFTEALQSLIKLASLQTSFVTLDQAIKLTNRRVNALEKVIQPRIQNTISYIISELDELEREEFFRLKKIR 208
                 8776444445555679*******************************************************************************98 PP

>> GIDA_assoc  GidA associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.8   2.7   3.4e-06     0.012      49     199 ..      71     219 ..      63     225 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 3.4e-06
                 HHHHHHTTSS-HHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHH.......HHHT....EHHHHCTTST--HHHHHCCHHHHHHHSCHHHHHHHHH.H CS
  GIDA_assoc  49 tekgrelGlvseeryekfeekkeeieelkellkstklkseewkkl......lekkeskklslaellkrpevkledlleelpeeeeeseeeleqveie.a 140
                  e  +++G +s + +e++++  ++++  ++ ++                  + ++++++  ++++++r   ++++ ++ ++e+ ++   +l +++++ +
  EFC38179.1  71 AEARYNAGDISYAVIESVKSAATKVKMRTDNIAG----------VtlpvfqQDDSSQSEEGMTSMISRGGEQIQNCKSIFTEALQSL-IKLASLQTSfV 158
                 4444555555555555555555555555555555..........334433233455566678899***9999999955554444444.44444444427 PP

                 HCHHHHHHHHHHCHHHHHHHTSB--TTS-C..CCSTT--CHHHHHHHHH--SCHHHHTTST CS
  GIDA_assoc 141 kYegyiekqeeeieklkkeenlkipedldY..skikgLskearekLkkvrPetlgqAsris 199
                 + ++ i+  ++++++l+k  + +i++++ Y  s++++L++e+  +Lkk+r +++++A+r +
  EFC38179.1 159 TLDQAIKLTNRRVNALEKVIQPRIQNTISYiiSELDELEREEFFRLKKIRNKKIKDAQRKQ 219
                 899**************************95567***********************9955 PP

>> AAA_31  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.1   0.00012      0.44      78     125 ..       5      52 ..       1      59 [. 0.84
   2 ?    1.3   0.2     0.081   2.9e+02      82     111 ..     142     178 ..     109     194 .. 0.57
   3 ?   -0.6   0.2      0.31   1.1e+03      82      97 ..     187     202 ..     156     249 .. 0.50

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00012
      AAA_31  78 venldlipssidLaeaeielvelekkeeilkellekvkdeYDyiiiDc 125
                  ++l+++ps + L++++i+l++++k  + lk++ ++++ ++  i+ D+
  EFC38179.1   5 KNRLQVLPSRMTLSNMKIRLQGAKKGYSLLKKKSDALNIKFRSILKDI 52 
                 4567**********************9999999888888887777665 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.081
      AAA_31  82 dlipssidLaeaeielvelekk.......eeilkell 111
                 + + s i+La++++++v+l++         ++l++++
  EFC38179.1 142 EALQSLIKLASLQTSFVTLDQAikltnrrVNALEKVI 178
                 5566777777777777777666333322244455544 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.31
      AAA_31  82 dlipssidLaeaeiel 97 
                 + i s++d  e e  +
  EFC38179.1 187 SYIISELDELEREEFF 202
                 4444443322222222 PP

>> DUF4672  Domain of unknown function (DUF4672)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.29     1e+03      80     103 ..     114     137 ..      86     161 .. 0.62
   2 ?   10.9   0.8   7.3e-05      0.26       9      61 ..     193     246 ..     190     251 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.29
     DUF4672  80 drlqskqdegacvmhqe..cqiqsce 103
                 d   s+ +eg++ m      qiq c+
  EFC38179.1 114 DS--SQSEEGMTSMISRggEQIQNCK 137
                 33..3444555544443235676665 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 7.3e-05
     DUF4672   9 ldPlpkkkrhlrkvvrtkrmrkskrkekveakcppilptplapp.qseedevvd 61 
                 ld l +++ +  k +r k+++  +rk+k+  +  ++ pt + p  q+++ +v+d
  EFC38179.1 193 LDELEREEFFRLKKIRNKKIKDAQRKQKIADELKKLNPTSSEPVhQTQQKNVLD 246
                 77888887777899****************************963666666666 PP

>> Latarcin  Latarcin precursor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1         2   7.1e+03      72      78 ..      47      53 ..      34      73 .. 0.58
   2 ?   -2.3   0.0       1.7     6e+03      28      36 ..     169     177 ..     131     190 .. 0.66
   3 ?   10.4   2.1   0.00018      0.66      13      51 ..     192     229 ..     188     243 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2
    Latarcin 72 kmgeklk 78
                ++ +++k
  EFC38179.1 47 SILKDIK 53
                3333333 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.7
    Latarcin  28 emvnnlRkv 36 
                   vn l kv
  EFC38179.1 169 RRVNALEKV 177
                 345666554 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00018
    Latarcin  13 eLdelergainrklmemvnnlRkvqgRLeemvenlrkve 51 
                 eLdeler++++ +l +  n+  k+++R ++++++l+k++
  EFC38179.1 192 ELDELEREEFF-RLKKIRNKKIKDAQRKQKIADELKKLN 229
                 9*****99996.599999**99**************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1634  (0.0911373); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1498.25
//
Query:       EFC38180.1  [L=821]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-50  170.4   6.9    3.8e-50  170.4   6.9    1.9  2  DENN      DENN (AEX-3) domain
      3e-18   66.3   0.1    1.4e-17   64.2   0.1    2.3  1  uDENN     uDENN domain
    8.2e-10   38.5   4.5    2.3e-09   37.1   4.5    1.9  1  dDENN     dDENN domain
  ------ inclusion threshold ------
      0.093   12.6   0.2       0.18   11.7   0.2    1.4  1  DUF928    Domain of Unknown Function (DUF928)


Domain annotation for each model (and alignments):
>> DENN  DENN (AEX-3) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  170.4   6.9   8.6e-54   3.8e-50       2     186 .]     213     394 ..     212     394 .. 0.97
   2 ?   -2.4   0.1       0.9     4e+03      37      96 ..     529     588 ..     493     590 .. 0.55

  Alignments for each domain:
  == domain 1  score: 170.4 bits;  conditional E-value: 8.6e-54
        DENN   2 ipkalcilsrlpffelfkkiLkalekrlkssskeaplesfianlllevplPapgktlklvslaveekillqrpedselPledvdlkelfrcLsienilq 100
                 ++k+++++s++pf++lfk +L+++++ + + sk  p+e+fi+n++ evplP +gk ++ +s  ++++i ++rp ++elP+ +vd++ lf +Lsieni+ 
  EFC38180.1 213 MSKSIVLISHYPFYNLFKFFLTQMYRISITPSK-IPIERFISNFIFEVPLPCQGKVQVHYS-IGDKEIFITRPPPNELPMAEVDFELLFCTLSIENIMI 309
                 789************************999995.***********************9966.99999******************************** PP

        DENN 101 lfeavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvleaPtPfiiGvesslleleekpledvvlvDldkn 186
                 lf +vL E++i+++S+++a+Lt+++e +++l++P+kW+hiyiP+lpa+ +++l aP+Pf++G+ +++ + + + ++dv  +Dld+n
  EFC38180.1 310 LFDLVLQEKKILFTSSHVALLTQISEIICHLVFPFKWHHIYIPLLPAKCAEFLFAPVPFMMGLAKDFVN-NIEIPSDVFQIDLDNN 394
                 *********************************************************************.**************96 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.9
        DENN  37 plesfianlllevplPapgktlklvslaveekillqrpedselPledvdlkelfrcLsie 96 
                 ++e+f+   l +v   + +   +l+ +  +e+    r++++++ ++++ ++ ++ +Ls++
  EFC38180.1 529 TFERFLLDRLEKVNQNEVQYFEELMIQKDNESKFKFRKQPTPFLSKNFAISRTLMALSPD 588
                 444444444444444333333333332223332223333444434677777777777666 PP

>> uDENN  uDENN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.2   0.1     3e-21   1.4e-17       1      65 [.     110     171 ..     110     172 .. 0.90

  Alignments for each domain:
  == domain 1  score: 64.2 bits;  conditional E-value: 3e-21
       uDENN   1 PevldryPpadhedfp.pedvplFcfPeglewsssteksserpepefFsFvLTdedgsrvYGaClt 65 
                 P vldryP +d+++ p ++++plFcfP+g    +   + +e + p +++FvLT +dg+++YGaCl+
  EFC38180.1 110 PIVLDRYPREDYPSAPlSPEIPLFCFPNGE---I-GIRIDECTLPMYYTFVLTAADGNKTYGACLN 171
                 679**************************4...3.4556778899********************8 PP

>> dDENN  dDENN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   4.5   5.2e-13   2.3e-09       1      49 [.     504     551 ..     504     552 .. 0.93

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 5.2e-13
       dDENN   1 FdkeaFlksqpkshrpFlsrfletQmFarFIderlel.sgsdpsldlFDe 49 
                 F+k+aF  + p++ r+F++ fl+tQ F+rF+ +rle+ +++  ++++F+e
  EFC38180.1 504 FNKNAFTHQLPEQARSFMEIFLHTQTFERFLLDRLEKvNQN--EVQYFEE 551
                 9***********************************96554..79***98 PP

>> DUF928  Domain of Unknown Function (DUF928)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.2     4e-05      0.18      13      52 ..     578     615 ..     566     661 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4e-05
      DUF928  13 akkpltaLvPesnvglTvserPtflfyvP.......sesakevefvl 52 
                  + +l+aL P+++ +lT s +P +++y P                + 
  EFC38180.1 578 ISRTLMALSPDNS-NLTSSTEPYIYLYFPtkldhtlF--------TK 615
                 5689******777.6**************64443331........22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (821 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       942  (0.0525406); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 4726.84
//
Query:       EFC38181.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.01   16.0   0.3      0.018   15.1   0.3    1.4  1  F5_F8_type_C  F5/8 type C domain


Domain annotation for each model (and alignments):
>> F5_F8_type_C  F5/8 type C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.3     1e-06     0.018      11     123 ..     439     543 ..     430     546 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1e-06
                   TTGGGGGGSSSTTSSEEESSSSTT.EEEEEEEEEEEEEEEEEEEECSSTTSSEEEEEEEEEESSSSSEEEEEEECE.EESSSSSSSEEEEEEEEEEE CS
  F5_F8_type_C  11 ewpaaaaldGnkntaWsssssddk.qwlqvdLgkpkkidgvvtqgrqdggnayvksykiqvsddgetWttvkdekv.pgnsdnstpvtntfdppvka 105
                   ++++  a+d ++++ W s+++    + + vdL ++ +  ++++       +++  + k + s d ++W + ++ ++ ++n+      +++f+ +v  
    EFC38181.1 439 NNNPTRAVDSDPSSCWQSNRNVGMdSFFGVDLYSVVTDIAIEIIYSHT--KDFHATLKTRHSIDRKNWVDTSAASYeSNNFS-----RHSFKDSV-- 526
                   5578999**********88888778*******9988888888887754..99****************99988555455555.....89999776.. PP

                   EEEEEEEEEEESSSSSEE CS
  F5_F8_type_C 106 ryvrltptswnggngial 123
                   ry+ +  ++  ++n++++
    EFC38181.1 527 RYIEFFTQT-GSRNKFGI 543
                   899988887.66666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 3157.46
//
Query:       EFC38182.1  [L=448]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-22   79.7  57.1    2.5e-06   27.7   9.5    4.5  4  EGF_2            EGF-like domain
    9.2e-13   48.3   0.0    1.4e-11   44.5   0.0    2.1  1  UPF0020          Putative RNA methylase family UPF0020
    5.2e-09   36.1   0.0      1e-08   35.1   0.0    1.5  1  Methyltransf_31  Methyltransferase domain
    5.3e-07   30.2   0.0    1.3e-06   29.0   0.0    1.6  1  Methyltransf_11  Methyltransferase domain
    1.8e-06   28.6   0.0    5.3e-06   27.1   0.0    1.9  1  Methyltransf_25  Methyltransferase domain
    0.00014   21.3   0.0     0.0002   20.8   0.0    1.1  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
    0.00077   19.0   0.0     0.0038   16.7   0.0    1.8  2  AviRa            RRNA methyltransferase AviRa
    0.00084   18.9   0.0     0.0015   18.1   0.0    1.3  1  MTS              Methyltransferase small domain
  ------ inclusion threshold ------
      0.022   14.6   0.0      0.063   13.1   0.0    1.8  1  Methyltransf_23  Methyltransferase domain
      0.025   14.9  43.1       0.36   11.2   5.7    5.0  4  EGF              EGF-like domain
       0.17   11.6   0.0       0.28   10.9   0.0    1.3  1  Met_10           Met-10+ like-protein
        2.2    9.1  53.5       0.46   11.2   6.1    5.0  4  hEGF             Human growth factor-like EGF


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   7.8   1.9e-08   2.8e-05       6      32 .]      59      84 ..      55      84 .. 0.93
   2 !   24.1   7.4   2.4e-08   3.5e-05       5      32 .]      97     123 ..      93     123 .. 0.91
   3 !   27.7   9.5   1.7e-09   2.5e-06       3      32 .]     134     162 ..     133     162 .. 0.92
   4 !   21.8   8.4   1.2e-07   0.00018       5      32 .]     175     201 ..     171     201 .. 0.90

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 1.9e-08
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                ++C+ghG C++++ +C+C sgy+G +C
  EFC38182.1 59 SACSGHGGCISPN-NCSCVSGYYGSDC 84
                68********999.8************ PP

  == domain 2  score: 24.1 bits;  conditional E-value: 2.4e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C +hG+C++++ +C+C s y+Gk C
  EFC38182.1  97 TSTCTNHGSCISPN-NCSCLSDYYGKEC 123
                 579********999.8************ PP

  == domain 3  score: 27.7 bits;  conditional E-value: 1.7e-09
       EGF_2   3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++++ C+ghGtC +++ +C+C +gy+G++C
  EFC38182.1 134 TNGSVCSGHGTCLSPN-NCSCLAGYYGNDC 162
                 56899********999.8************ PP

  == domain 4  score: 21.8 bits;  conditional E-value: 1.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+ghG C++++ +C+C +gy+G+ C
  EFC38182.1 175 ASACSGHGGCISPN-NCSCLDGYYGNVC 201
                 678********999.8*********998 PP

>> UPF0020  Putative RNA methylase family UPF0020
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.5   0.0   9.2e-15   1.4e-11      31     192 ..     288     426 ..     279     431 .. 0.87

  Alignments for each domain:
  == domain 1  score: 44.5 bits;  conditional E-value: 9.2e-15
                 -EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE-- CS
     UPF0020  31 pllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvivtnp 129
                 +++DP+ GsGt+ +    l ++                      ++++ly +D++   v   ++N +k + +++ +  +   + L+ +++++dv+++++
  EFC38182.1 288 TFVDPFAGSGTLSLSLNYLFTDND--------------------PKVQLYNIDFNLDEVSVMKDNCSKNRNNHILNCDS---RFLPFRNESIDVVISDM 363
                 799*********987777777766....................5788******************9999998887766...55665588********* PP

                 --------HHHHHHHHHHHHHHHHHH-TT..-EEEEEESSHHHHHCC---ESEEEEEEETTEE CS
     UPF0020 130 PYGerlgskkalekLYseflrelkrvlrgggrlvlltsenkalekaleeralrkvkeknvklg 192
                 P+G   +++ ++ k Y+++ ++l+r+++ +g  +llt e   le+ l+ r+   ++ ++v lg
  EFC38182.1 364 PFGVLCENHSRNSKVYPKIVKQLERIVKPDGIVMLLTIELTLLESQLNARNRWTFTTQKVTLG 426
                 ***********************************************9997777777777666 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.1   0.0   6.9e-12     1e-08       4     122 ..     286     410 ..     283     440 .. 0.77

  Alignments for each domain:
  == domain 1  score: 35.1 bits;  conditional E-value: 6.9e-12
  Methyltransf_31   4 glrvlDlGCGtGeltfelae..elgp.kaevvGiDiseeaielArenaqklgldnveFeqgdieeleklledekfDlilsnevl........na 86 
                       ++++D+ +G+G+l++ l+   + ++ k ++++iD++ + +++++ n++k+   n +   +d   l+  +  e++D+++s+ ++          
       EFC38182.1 286 LVTFVDPFAGSGTLSLSLNYlfTDNDpKVQLYNIDFNLDEVSVMKDNCSKNR--NNHILNCDSRFLP--FRNESIDVVISDMPFgvlcenhsRN 375
                      57899**************87633335999*****************88766..5689999999999..999*********6666669944444 PP

  Methyltransf_31  87 ladpdkileeiervlkpggilliedpr...llaelpakv 122
                       +  +ki +++er +kp+gi+++ ++    l      ++
       EFC38182.1 376 SKVYPKIVKQLERIVKPDGIVMLLTIEltlL----ESQL 410
                      444579999***************9993332....3333 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.0   0.0   8.6e-10   1.3e-06       6      95 ..     295     397 ..     291     398 .. 0.79

  Alignments for each domain:
  == domain 1  score: 29.0 bits;  conditional E-value: 8.6e-10
                      TTSHHHHHHH....HTT...SEEEEEES-HHHHHHHHHHCCHHT-EEEETTEECCCTSS-TT-EEEEEEES...-CCC-.....CCHHHHHHHH CS
  Methyltransf_11   6 GtGrlaeala....krg...arvvgvDlskemlklakekaseeglkvefvvadaeklpfednsfDlvvsse...vlhhv.....edpekalkei 84 
                      G+G l+  l     +      +++++D++   + + k++ s++++   ++ +d + lpf+++s+D+v+s +   vl+       +   k++k++
       EFC38182.1 295 GSGTLSLSLNylftD-NdpkVQLYNIDFNLDEVSVMKDNCSKNRN-NHILNCDSRFLPFRNESIDVVISDMpfgVLCENhsrnsKVYPKIVKQL 386
                      344444444432342.246799*********************98.4799999999**************966644444567777999****** PP

                      HHHEEEEEEEE CS
  Methyltransf_11  85 aRvLkpgGllv 95 
                       R++kp+G+++
       EFC38182.1 387 ERIVKPDGIVM 397
                      ********987 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.0   3.5e-09   5.3e-06       5      97 .]     293     394 ..     289     394 .. 0.84

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 3.5e-09
                      T-TTSHHHHHHHCTS....TSSEEEEEESSHHHHHHHHHHHHHTTTTEEEEESBCCGBSSSTTTEEEEEE.....EST.GGGSSHHHHHHHHHH CS
  Methyltransf_25   5 GcGtGrltlalakrl....gkakvtgvDiseemleaareraeeeglnvefvqgdaedlpfedgsfDlvvs.....sga.lhhlsdedlekalke 88 
                       +G+G+l+l l   +    +k +++ +D++ + +  ++ ++++++ n +++++d + lpf ++s+D+v+s     + +  h  + + ++k++k+
       EFC38182.1 293 FAGSGTLSLSLNYLFtdndPKVQLYNIDFNLDEVSVMKDNCSKNR-NNHILNCDSRFLPFRNESIDVVISdmpfgVLCeNHSRNSKVYPKIVKQ 385
                      579999999999999875449********************8765.99**********************65544333233477778899**** PP

                      HHHHEEEEE CS
  Methyltransf_25  89 iarvLkpgG 97 
                      + r++kp+G
       EFC38182.1 386 LERIVKPDG 394
                      *******99 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   1.3e-07    0.0002      34     160 ..     265     407 ..     259     430 .. 0.72

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 1.3e-07
                      HHHHHHHHH--S--TT.......EEEEES-TT-HHHHHHHHHHHHHH.EEEEEES-HHHHHHHHHHHHHHTSSTEEEEE--TTT-TTS-T-EEE CS
  Ubie_methyltran  34 lWkkfveklvavkrga.......kvlDvagGtgDlafklsdsvgekg.kvvvlDinenmLkvgekklkeegkinieflqanaeeLpfeddsfDv 119
                      lWk+ +++ +  +          +++D  +G+g l+++l     ++  kv++ +i+ n+ +v+  k + +   n + l+ ++  Lpf ++s Dv
       EFC38182.1 265 LWKTLLMENSILRDKLfqqsqlvTFVDPFAGSGTLSLSLNYLFTDNDpKVQLYNIDFNLDEVSVMKDNCSKNRNNHILNCDSRFLPFRNESIDV 358
                      6666555544433333334556699*************99887655446666555555555555554444455667799**************9 PP

                      EE..EES-G......GG-S-HHHHHHHHHHHEEEEEEEEEEEE----SH CS
  Ubie_methyltran 120 vt..vsfGl......rnvtDklkaLkeayrvlkpGGrlvvlefskvelp 160
                      v   + fG+      rn   ++k +k++ r++kp G+++ l +    l+
       EFC38182.1 359 VIsdMPFGVlcenhsRNSKVYPKIVKQLERIVKPDGIVMLLTIELTLLE 407
                      853378**888888899999*****************999876555544 PP

>> AviRa  RRNA methyltransferase AviRa
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.25   3.7e+02      51      99 ..     283     333 ..     270     342 .. 0.79
   2 !   16.7   0.0   2.5e-06    0.0038     162     213 ..     351     401 ..     322     417 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.25
       AviRa  51 egapltlyDpCCGgayLltvlgllhgkk..ikkvlasDvdeevlelakkNL 99 
                 +++ +t  Dp  G++ L   l +l +++    +++  D++ + +++ k+N 
  EFC38182.1 283 QSQLVTFVDPFAGSGTLSLSLNYLFTDNdpKVQLYNIDFNLDEVSVMKDNC 333
                 45568999*************999987622456788899999888888885 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 2.5e-06
       AviRa 162 eaekevdivitDlPYGelvswqgeseepvkqlleslaavldpeesvvaviad 213
                   ++++d+vi D+P+G l + ++ +++  ++++++l++++ + +++v++ + 
  EFC38182.1 351 FRNESIDVVISDMPFGVLCENHSRNSKVYPKIVKQLERIV-KPDGIVMLLTI 401
                 34456***********************************.56888877654 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0     1e-06    0.0015      33     139 ..     287     400 ..     270     420 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1e-06
                 SEEEEET-TTSHHHHHHH....HHTTC.EEEEEESBHHHHHHHHHHHHHTTGCEEEEE-STTTTSTTS-EEEEEE---ST...TTCHCHHHHHHHHHHH CS
         MTS  33 gkvlDlGcGaGvlgaala....kespeaevtlvdvdarAlesakenleanklevevvasdvleeveekkfdlivsNPPfh...agkatelavaeeliae 124
                  + +D  +G G l+++l     ++ p++++  +d +   + + k n+++n+ +  +   + +  + ++++d+++s  Pf    +++  + +v  +++++
  EFC38182.1 287 VTFVDPFAGSGTLSLSLNylftDNDPKVQLYNIDFNLDEVSVMKDNCSKNRNNHILNCDSRFLPFRNESIDVVISDMPFGvlcENHSRNSKVYPKIVKQ 385
                 45788889****99998622225678899999999****************9877777777889999************633367788999******** PP

                 HHHHEEEEEEEEEEE CS
         MTS 125 AkeaLkegGeLliVa 139
                  +++ k++G  ++ +
  EFC38182.1 386 LERIVKPDGIVMLLT 400
                 *********887765 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   4.2e-05     0.063      46     133 ..     315     416 ..     270     429 .. 0.67

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 4.2e-05
  Methyltransf_23  46 svtgvDlspeaveiae....kakkaqkdqfdeqeaaepqgkfdlIvlre...vlehvp..d...ppellrqiatllkpgGylllseplasl..k 125
                      +++++D +   v+  +    k ++++  + d+ + ++ ++++d++++ +   vl+  +  +   +p+ ++q+ +++kp+G ++l+++   l  +
       EFC38182.1 315 QLYNIDFNLDEVSVMKdncsKNRNNHILNCDSRFLPFRNESIDVVISDMpfgVLCENHsrNskvYPKIVKQLERIVKPDGIVMLLTIELTLleS 408
                      555555555555544477777777777777788888899999999985533367666633356688********************86655332 PP

  Methyltransf_23 126 edrllldw 133
                      ++++   w
       EFC38182.1 409 QLNARNRW 416
                      33333334 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   5.4    0.0088        13       6      31 ..      61      82 ..      58      83 .. 0.88
   2 ?    8.6   3.8    0.0015       2.3       4      31 ..      96     121 ..      93     122 .. 0.88
   3 ?   11.2   5.7   0.00024      0.36       4      31 ..     135     160 ..     133     161 .. 0.87
   4 ?    6.3   4.4    0.0083        12       6      31 ..     178     199 ..     171     200 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0088
                STTT-EEEEETTTEEEEEECTTEEST CS
         EGF  6 CsngGtCvdtgrggytCiCpeGytGk 31
                Cs++G C+++     +C C +Gy G+
  EFC38182.1 61 CSGHGGCISPN----NCSCVSGYYGS 82
                777777*9999....*********97 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0015
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 n+  C n+G C+++     +C C + y Gk
  EFC38182.1  96 NTstCTNHGSCISPN----NCSCLSDYYGK 121
                 5566***********....********998 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00024
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 n   Cs++GtC+++     +C C  Gy G+
  EFC38182.1 135 NGsvCSGHGTCLSPN----NCSCLAGYYGN 160
                 5577*******9999....*********97 PP

  == domain 4  score: 6.3 bits;  conditional E-value: 0.0083
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C+++     +C C  Gy G+
  EFC38182.1 178 CSGHGGCISPN----NCSCLDGYYGN 199
                 999999*****....*********96 PP

>> Met_10  Met-10+ like-protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00019      0.28      96     173 ..     279     360 ..     257     381 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00019
                 TT--TT-EE..EETT-TTTCCHHHCCHH....TTSSEEEEEES-HHHHHHHHHHHHHTT-TTCEEEEES-GGG---.TT-EEEEE CS
      Met_10  96 klveegevV..vdvfAGiGpfaipiaky....skakrvlaidlnPesvkylkeniklNkvekvvkpileDgrevir.eqladrvv 173
                 kl+++ ++V  vd fAG G +++++  +      +++++ id n + v  +k+n   N+ ++++   + D+r +   ++ +d v+
  EFC38182.1 279 KLFQQSQLVtfVDPFAGSGTLSLSLNYLftdnDPKVQLYNIDFNLDEVSVMKDNCSKNRNNHIL---NCDSRFLPFrNESIDVVI 360
                 45888887755899*********998652211335789*********************99887...778777654455556555 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   9.4     0.053        80       1      22 []      61      79 ..      61      79 .. 0.90
   2 ?    7.6   5.5    0.0041       6.2       1      20 [.     100     116 ..     100     118 .. 0.82
   3 ?   11.2   6.1   0.00031      0.46       1      22 []     139     157 ..     139     157 .. 0.91
   4 ?    4.1   8.6     0.054        81       1      22 []     178     196 ..     178     196 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.053
                --TT-EES..-SS.-EE--TTX CS
        hEGF  1 CnngGtCidgvggykCiCpPGy 22
                C+++G Ci     + C C +Gy
  EFC38182.1 61 CSGHGGCI---SPNNCSCVSGY 79
                9*******...4478******9 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0041
                 --TT-EES..-SS.-EE--T CS
        hEGF   1 CnngGtCidgvggykCiCpP 20 
                 C n+G+Ci     + C C++
  EFC38182.1 100 CTNHGSCI---SPNNCSCLS 116
                 99******...4478***87 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00031
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++GtC      + C C+ Gy
  EFC38182.1 139 CSGHGTCL---SPNNCSCLAGY 157
                 ********...4478******9 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.054
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G Ci     + C C+ Gy
  EFC38182.1 178 CSGHGGCI---SPNNCSCLDGY 196
                 9*******...4478******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (448 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       523  (0.0291706); expected 358.6 (0.02)
Passed bias filter:                      232  (0.0129399); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2647.58
//
Query:       EFC38183.1  [L=315]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-60  202.7   0.0    1.9e-59  201.3   0.0    1.6  2  P34-Arc   Arp2/3 complex, 34 kD subunit p34-Arc


Domain annotation for each model (and alignments):
>> P34-Arc  Arp2/3 complex, 34 kD subunit p34-Arc
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0     0.084   1.5e+03     121     144 ..       2      25 ..       1      31 [. 0.82
   2 !  201.3   0.0   1.1e-63   1.9e-59       1     237 [.      54     295 ..      54     297 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.084
                 --SSSSHHHHHHHHHHHHH----- CS
     P34-Arc 121 vFkdetDkvlgkvFLqefvdarkr 144
                 +F ++  k++  ++L++f  + ++
  EFC38183.1   2 IFLEAGNKIIQEILLKQFDASTRQ 25 
                 7889999***********988877 PP

  == domain 2  score: 201.3 bits;  conditional E-value: 1.1e-63
                 EEEE-TTHHHHHTTTHHHHHHHHSTTTE......E---TTSSEEE---TTS------SHHHHHHHHHTHHHHHTSHHHHHHHTHHHH------HHTTT- CS
     P34-Arc   1 vsislkcwkelkkygaeellkreYgkllk.....aepesgydvsllvdleelpedeeekeelikklsllkrnllaapfekafeeqeelseekesekeev 94 
                 +si+++  ke+++yg  el+k++   l       +  ++++++++++d+e+   +e++k++++k+l ++k+++++a+f +a++++++       e+ e 
  EFC38183.1  54 LSIYVHGEKEFNQYGGIELVKKTLPGLDVkapglTVDDQKHTFTVTIDVEK---EEKNKDKWLKELPRVKTTYMSAVFLQAMDKHAK------GEQFEP 143
                 699**********************9998889888999************9...5688*****************************......6799** PP

                 EEE--SSS--EEEEE-S.SEEEEEEEE--SSSSHHHHHHHHHHHHH-----.------EEEE-SSS--S---S-------........---EEEEEEEE CS
     P34-Arc  95 aaikYrddEaiyikpsk.drvtvifstvFkdetDkvlgkvFLqefvdarkr.aiqsaPqvlfsekepplelrdlkeakkk........envgyvtfvLf 183
                 ++++Yr dE+iyi + k + ++v++s++F+d +D+v+++ FL+ef+da+k+ a++ aP++ fs+ + + el d+k++++         e +g+v++ L+
  EFC38183.1 144 IKVPYRPDENIYIISYKgKSLVVVYSILFRDPDDVVFANGFLCEFKDAKKDrALNAAPNMNFSQGQLAGELVDVKSVTEPkdertlkkEGWGFVSIGLL 242
                 *************9988799******************************99**********************9888444567777799********* PP

                 GGGG.-TTTHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSS CS
     P34-Arc 184 prhlkteekrentisliqlfRnylhYHiKcsKaylhsrmRarvseflkvLnrAk 237
                 ++h ++++k+ nt +l+  fR+ylhYH+Kc+Kay+h+rmR+ v++++  Ln Ak
  EFC38183.1 243 DNH-TKADKQLNTAELLLGFRSYLHYHLKCMKAYMHIRMRESVEKLMLNLNAAK 295
                 ***.7************************************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       657  (0.0366445); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1873.92
//
Query:       EFC38184.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-10   41.0  12.3    0.00031   21.0   0.7    5.2  6  Bactofilin       Polymer-forming cytoskeletal
  ------ inclusion threshold ------
       0.16   11.7   0.0        1.3    8.8   0.0    2.5  3  S4               S4 domain
       0.49   11.0   4.9        8.6    6.9   1.9    4.0  3  YceI             YceI-like domain
        2.6    7.9  12.4         23    4.8   0.0    5.7  6  YabP             YabP family
        3.2    8.5   4.3         12    6.6   1.4    2.4  2  Transglycosylas  Transglycosylase-like domain
        4.9    5.7   8.5       0.89    8.1   3.4    2.2  2  FapA             Flagellar Assembly Protein A


Domain annotation for each model (and alignments):
>> Bactofilin  Polymer-forming cytoskeletal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.4   5.7e-05      0.17      10      60 ..      44      93 ..      39     120 .. 0.84
   2 ?    1.2   0.0      0.16   4.7e+02      60      96 ..     133     170 ..     110     172 .. 0.61
   3 ?    2.9   0.0     0.046   1.4e+02       6      28 ..     172     194 ..     170     204 .. 0.88
   4 !    6.6   0.0    0.0031       9.3      22      64 ..     229     273 ..     213     276 .. 0.70
   5 !   21.0   0.7     1e-07   0.00031       8      68 ..     275     343 ..     272     350 .. 0.79
   6 ?   -2.1   0.0       1.7     5e+03      11      36 ..     350     375 ..     346     383 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.7e-05
  Bactofilin 10 kGelevegdlridGkveGdieakgklvvgeggkvegnikaeevvvaGtvk..G 60
                 G+l++egd++ +G +   i+   +l+v  ++ ++g+i+ + ++v+G+v   G
  EFC38184.1 44 IGNLTFEGDFHASG-IIAMIND--SLIVDGSSLINGSIDHGLIQVNGSVAsnG 93
                59999999999999.7788844..6***********************87334 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.16
  Bactofilin  60 GnveaeekvelkktakveGdikaksle.ieegavfeGk 96 
                 G v+++++ + +++ +++Gd+  +s++ ++   +++G+
  EFC38184.1 133 GFVYSNQSWNTNGSLTIQGDLILPSMDeFSGTLQVNGT 170
                 55666666666666666666666666434444455554 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.046
  Bactofilin   6 gtkikGelevegdlridGkveGd 28 
                 +++i+G+l++ g++ +dG+++G+
  EFC38184.1 172 NSSISGDLSIIGSMLLDGSFNGN 194
                 57899999999999999999997 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0031
  Bactofilin  22 dGkveGdi.eakgklvvgeggkvegnika.eevvvaGtvkGnvea 64 
                  + ++G++ +++g+l ++ +  ++g+  + e+++++G +  nv +
  EFC38184.1 229 TAVIDGTMkSSDGQLYINGSMIISGTFLSnENLELSGYLANNVMV 273
                 345677774558888888888888885554778888888877765 PP

  == domain 5  score: 21.0 bits;  conditional E-value: 1e-07
  Bactofilin   8 kikGelevegdlridG..kveGdi..eakgklvvgeggkvegnikaee.vvvaGt..vkGnveaee.kv 68 
                 +++G+++   +  idG  +v+G++  + ++ l+++ +++v+gn++ ++ + + G+  ++G+v+ ++ +v
  EFC38184.1 275 EMTGTISLPCSTLIDGnlTVNGNLnsTVGSMLTINGTTHVNGNLTLSHaLLITGNltIHGTVHLNNtNV 343
                 68999999999999997777999966568999***********99966488888755558888776555 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 1.7
  Bactofilin  11 GelevegdlridGkveGdieakgklv 36 
                 G++++ g+++ + + +G ++a++ l+
  EFC38184.1 350 GDFTSVGGIVANNTADGALRADNVLT 375
                 67888888888888888888776655 PP

>> S4  S4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.0   0.00045       1.3      23      40 ..      78      95 ..      74     101 .. 0.86
   2 ?   -2.3   0.0       1.3   3.8e+03      25      33 ..     240     248 ..     239     250 .. 0.82
   3 ?   -2.4   0.0       1.4   4.1e+03      26      35 ..     290     299 ..     289     309 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00045
                HHTTTEEETTEEE--TT- CS
          S4 23 IehGrVlVNGkvvkdpsy 40
                I hG ++VNG v+ + s 
  EFC38184.1 78 IDHGLIQVNGSVASNGSL 95
                99**********997765 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.3
                 TTTEEETTE CS
          S4  25 hGrVlVNGk 33 
                 +G+ ++NG 
  EFC38184.1 240 DGQLYINGS 248
                 7999****7 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 1.4
                 TTEEETTEEE CS
          S4  26 GrVlVNGkvv 35 
                 G  +VNG   
  EFC38184.1 290 GNLTVNGNLN 299
                 88999*9765 PP

>> YceI  YceI-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0       0.2   5.9e+02      89     128 ..     161     200 ..      69     219 .. 0.68
   2 ?    4.8   0.8     0.013        39      86     100 ..     315     337 ..     157     353 .. 0.76
   3 ?    6.9   1.9    0.0029       8.6      18      86 ..     310     390 ..     298     394 .] 0.59

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.2
                 EEEEEEETTEEE.EEEEEEEEEEEECCEECEEEEEGGGGTC CS
        YceI  89 vtGdLtikGvtk.pvtlpvtvngaaagfsatgtidrtdFGl 128
                  +G+L+++G+ + +++ ++++ g+ +  +++++ + tdF++
  EFC38184.1 161 FSGTLQVNGTVNsSISGDLSIIGS-MLLDGSFNGNETDFNM 200
                 344444444333123334444332.2234455555555554 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.013
                 E...........EEEEEEETTEEE CS
        YceI  86 e.........akvtGdLtikGvtk 100
                 +           +tG+Lti+G+ +
  EFC38184.1 315 NgnltlshalL-ITGNLTIHGTVH 337
                 34444555533.788888888765 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0029
                 ...-EEEEECTE.....CCEEEE...TTT..EEEEEEE...EGGGEES..S.HCHHHHHHCTCTT-TTT--EEEECCCCEE CS
        YceI  18 gvskvtGrfkkv.....sgelsv.deddp.essvevti...dvasidt..gnakrdehlksadffdvakyPtatFvstsve 86 
                 g+++v+G+++       +g+l++    ++ + +v + +   d +s+     n++ d++l+ ++++  ++  ++tF+s +v+
  EFC38184.1 310 GTTHVNGNLTLShalliTGNLTIhGTVHLnNTNVAIIVqggDFTSVGGivANNTADGALRADNVLTFMNITDMTFTSIKVK 390
                 445777776664344446666662322332244555553334444433554556799999999999999999999998876 PP

>> YabP  YabP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.4     0.024        72      33      61 ..      63      91 ..      58      92 .. 0.88
   2 ?   -2.4   0.0       1.4   4.2e+03      48      59 ..     103     114 ..      98     116 .. 0.66
   3 ?    4.8   0.0    0.0078        23      33      61 ..     144     173 ..     142     175 .. 0.92
   4 ?    1.6   0.1     0.081   2.4e+02      29      58 ..     236     266 ..     225     271 .. 0.76
   5 ?   -1.0   0.0       0.5   1.5e+03      46      61 ..     285     300 ..     272     305 .. 0.76
   6 ?    0.9   0.6      0.14   4.1e+02      31      59 ..     307     336 ..     290     338 .. 0.61

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.024
        YabP 33 kgkltIkGenLhikklskgelkieGkIds 61
                +  l++ G++L  ++++ g ++++G + s
  EFC38184.1 63 NDSLIVDGSSLINGSIDHGLIQVNGSVAS 91
                5679*********************9876 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.4
        YabP  48 lskgelkieGkI 59 
                 +s+g l i+G +
  EFC38184.1 103 FSNGSLLINGSF 114
                 457777777765 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.0078
        YabP  33 kgkltIkGenLhikkls..kgelkieGkIds 61 
                 +g ltI+G +L + +++  +g+l+++G+++s
  EFC38184.1 144 NGSLTIQG-DLILPSMDefSGTLQVNGTVNS 173
                 79999**9.69******************98 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.081
        YabP  29 letkkgkltIkGenLhikkls.kgelkieGk 58 
                 +++++g+l I+G+    +++  +++l+++G 
  EFC38184.1 236 MKSSDGQLYINGSMIISGTFLsNENLELSGY 266
                 6778888888888766666556777777775 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 0.5
        YabP  46 kklskgelkieGkIds 61 
                 ++l +g+l+++G+++s
  EFC38184.1 285 STLIDGNLTVNGNLNS 300
                 5556788888888876 PP

  == domain 6  score: 0.9 bits;  conditional E-value: 0.14
        YabP  31 tkkgkltIkGenLhikkls..kgelkieGkI 59 
                 t +g+ +++G nL++++    +g+l+i G++
  EFC38184.1 307 TINGTTHVNG-NLTLSHALliTGNLTIHGTV 336
                 3344444444.45555555667777777766 PP

>> Transglycosylas  Transglycosylase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.1      0.13     4e+02      19      44 ..      83     108 ..      79     117 .. 0.83
   2 ?    6.6   1.4    0.0039        12      16      45 ..     119     148 ..     115     153 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.13
                      TT-TTSSSEBTTTTBEHHHHHHTTCC CS
  Transglycosylas  19 waintgnGyyGglqfsqstWeavgge 44 
                      +++n +    G l +s stW ++g  
       EFC38184.1  83 IQVNGSVASNGSLMISISTWFSNGSL 108
                      6778888889***********99975 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0039
                      SS-TT-TTSSSEBTTTTBEHHHHHHTTCCS CS
  Transglycosylas  16 ggnwaintgnGyyGglqfsqstWeavggek 45 
                      g++++ n + G  Gg+ +s+++W+ +g   
       EFC38184.1 119 GNAFELNGTLGHSGGFVYSNQSWNTNGSLT 148
                      556699*******************99865 PP

>> FapA  Flagellar Assembly Protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.2     0.089   2.7e+02     198     209 ..     136     171 ..      43     184 .. 0.55
   2 ?    8.1   3.4    0.0003      0.89     180     254 ..     288     370 ..     230     389 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.089
        FapA 198 k........................fkGsViikGnV 209
                                          f G+++++G V
  EFC38184.1 136 YsnqswntngsltiqgdlilpsmdeFSGTLQVNGTV 171
                 144444422222222223333333344444444444 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0003
        FapA 180 VdpvleikgdVdlstGn.IkfkGsViikGnVeegmkVkasgditikGvve.....satieAggnItikgGiigkgk..skikA 254
                 +d +l+++g+ +  +G+ ++ +G+ +++Gn +       +g++ti+G+v+      a i  gg+ t  gGi+ +++  + ++A
  EFC38184.1 288 IDGNLTVNGNLNSTVGSmLTINGTTHVNGNLTLSHALLITGNLTIHGTVHlnntnVAIIVQGGDFTSVGGIVANNTadGALRA 370
                 778899******999984679*************************8885222213445558888888888887767766666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       569  (0.0317363); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 2542.55
//
Query:       EFC38185.1  [L=215]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.082   13.1   0.3       0.66   10.2   0.0    2.1  2  MmoB_DmpM  MmoB/DmpM family
       0.15   11.8   0.0       0.22   11.2   0.0    1.2  1  DUF188     Uncharacterized BCR, YaiI/YqxD family COG1671


Domain annotation for each model (and alignments):
>> MmoB_DmpM  MmoB/DmpM family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1     0.085   7.6e+02       9      27 ..      77      93 ..      71      96 .. 0.76
   2 ?   10.2   0.0   7.3e-05      0.66      25      53 ..     114     143 ..     104     144 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.085
                -SHHHHHHHHHCCHH-TT- CS
   MmoB_DmpM  9 kseearavveaimadnpev 27
                k+e+  +v++ i+a+n +v
  EFC38185.1 77 KQEK--TVIDRIEAENNDV 93
                4444..59*****999876 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 7.3e-05
                 T.T-EEEE-SSEEEEEEESEEEEEHHHHHH CS
   MmoB_DmpM  25 p.evtvedrpayvridaegrleirreeiee 53 
                 p  ++ +d++ +++++ + +++++r++ie+
  EFC38185.1 114 PtGIVFDDNRDMLKVEEDMECVFDRDKIEN 143
                 5578889*********************96 PP

>> DUF188  Uncharacterized BCR, YaiI/YqxD family COG1671
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   2.5e-05      0.22      21      84 ..      58     122 ..      50     144 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.5e-05
      DUF188  21 lrlpssplvetvvVdsgadaaDdaIveraeagDlvvTqDipLA.arvlekgaaalsprGevytee 84 
                 l+l+++++ e ++ ++ +++  +++++r+ea++  v  D+pL  +  l+kg + l+p+G v++++
  EFC38185.1  58 LELTNNNTKEELIMKHVFEKQEKTVIDRIEAENNDVAPDLPLStKSFLAKGLISLKPTGIVFDDN 122
                 6667777888888999999999********************83568***************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.35s 00:00:00.88 Elapsed: 00:00:00.54
# Mc/sec: 1198.95
//
Query:       EFC38186.1  [L=306]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.6e-09   37.6   4.2    2.2e-09   37.1   4.2    1.3  1  Pkinase         Protein kinase domain
    1.4e-06   27.3   0.5    2.8e-06   26.4   0.5    1.4  1  Pkinase_fungal  Fungal protein kinase
    0.00015   21.2   0.1    0.00025   20.5   0.1    1.4  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
    0.00055   19.3   0.8    0.00078   18.8   0.8    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
      0.001   18.7   0.4     0.0024   17.5   0.4    1.6  1  RIO1            RIO1 family
     0.0029   17.0   1.0     0.0052   16.1   1.0    1.5  1  EcKinase        Ecdysteroid kinase
  ------ inclusion threshold ------
       0.12   12.3   0.0       0.16   11.8   0.0    1.2  1  APH             Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   4.2   8.7e-13   2.2e-09      49     198 ..     105     262 ..      71     304 .. 0.75

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 8.7e-13
                 HHHHHHHSCTTB--EEEE..EEESSEEEEEEE--TTEBHHHHHHHHSS--HH.....HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE.... CS
     Pkinase  49 ikilkklkhpnivrlyev..feekdelylvleyveggeladllerkgslsee.....eakkiakqilegleylHskgiiHrDlKpeNiLidekge.... 136
                 +k++++++ pni++++++  ++++ ++++   +++ +el + ++ ++ ++ +      + k +   l++l+ +H+kgi+H+D+  +Ni++  k      
  EFC38186.1 105 MKLMQEIRDPNICNIFYYgpVNSQLNITVQEKLLNYDELIKKMQSNQEYQGNsiirtIILKTLIGCLHALKCIHNKGIVHCDVSVHNIMFRMKTScdfd 203
                 6899999*****997655226777777788889999999999984444333311111444444556799**********************66666888 PP

                 EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STT CS
     Pkinase 137 lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfs 198
                   ++DF  +k l+s++  +      +Y +     + +++ k D+++l v++ +l+++     
  EFC38186.1 204 AVLIDFNNSKYLNSNQ-PSILNYKDDYTPQDP--NIRFTVKHDIFALSVVIKKLMANYSSVC 262
                 99************98.888888889988653..4578***************999877666 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.5   1.1e-09   2.8e-06     308     364 ..     163     217 ..     156     230 .. 0.89

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 1.1e-09
  Pkinase_fungal 308 llealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsd 364
                     +l+ l+ ++ +++  + ++gi+H D+S++Ni++   k+  +   +LiD++  k l+ 
      EFC38186.1 163 ILKTLIGCLHALKCIH-NKGIVHCDVSVHNIMFR-MKTSCDFDAVLIDFNNSKYLNS 217
                     799*************.*****************.77778*********98888774 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   9.7e-08   0.00025      95     170 ..     133     213 ..     112     219 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 9.7e-08
         Kdo  95 lterlegaqdLedllakwaelaee.l.krallka.vg..rliaklhragvnHadlyaknillqqeeeeeaeiwliDldkar 170
                 + e+l +  +L + +++ +e++++   +  +lk  +g   + + +h+ g+ H d+ ++ni+++ + + ++ ++liD++ ++
  EFC38186.1 133 VQEKLLNYDELIKKMQSNQEYQGNsIiRTIILKTlIGclHALKCIHNKGIVHCDVSVHNIMFRMKTSCDFDAVLIDFNNSK 213
                 678888888888888887775444131333444335522356789********************************9875 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.8     3e-07   0.00078      52     200 ..     105     256 ..      75     292 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 3e-07
                  HHHHHTS-BTTB--E..EEEEESSSSEEEEEE--TTEBHHHHHHHT...CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE CS
  Pkinase_Tyr  52 akimkklkhpnivkl..lgvctkeepllivteyvkgGdLlkfLrkk...ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvki 144
                  +k+m++++ pni ++  +g + ++ ++ +  +++++ +L k ++++   + +++  + +l+  +   ++++ +++k +vH d++  N++ + ++    
   EFC38186.1 105 MKLMQEIRDPNICNIfyYGPVNSQLNITVQEKLLNYDELIKKMQSNqeyQGNSIIRTIILKTLIGCLHALKCIHNKGIVHCDVSVHNIMFRMKTS--- 199
                  799*********996336777777778888889************9666667777788899999999***********************97766... PP

                  -ST.TTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHT CS
  Pkinase_Tyr 145 sDf.GLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEift 200
                  +Df ++  d +++++ ++++ + l++k        + +ft+k D+++ +v++  ++ 
   EFC38186.1 200 CDFdAVLIDFNNSKYLNSNQPSILNYKDDYTPQDPNIRFTVKHDIFALSVVIKKLMA 256
                  566223444545555566666666665333333345668888888888887766665 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.4   9.3e-07    0.0024      45     150 ..      85     210 ..      63     225 .. 0.64

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 9.3e-07
                 S-HHHHHHHHHHHHHHHHHHHHHTT.--S--........EEEEETTEEEEE--EETTEEGGBHHHCG-...HHHHHHHHHHHHH...HHHHHHHTSTEE CS
        RIO1  45 tnprklvklwaekEfrnLkrleeag.vpvPk........pielkrhvlvmefigedgvaapklkdvee...eeeaeelyeevle...emrklykeaglv 128
                 +++++    ++++Ef+n   ++ ++ ++ P+        p++ + ++ v e + + +  ++k++  +e   ++ ++++  ++l    +  k +++ g+v
  EFC38186.1  85 YKNKESYFKITNREFDNVFVMKLMQeIRDPNicnifyygPVNSQLNITVQEKLLNYDELIKKMQSNQEyqgNSIIRTIILKTLIgclHALKCIHNKGIV 183
                 44555555556666666555543333555543333333388999999999999977777788887774345555666555554456656677889**** PP

                 ESS-STTSEEEE....TT.EEEE--GT CS
        RIO1 129 HaDLSeyNvlvd....ed.kvviIDvs 150
                 H+D+S  N+++      d + v+ID+ 
  EFC38186.1 184 HCDVSVHNIMFRmktsCDfDAVLIDFN 210
                 **********86211134566788875 PP

>> EcKinase  Ecdysteroid kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   1.0     2e-06    0.0052     208     250 ..     172     214 ..      87     218 .. 0.71

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 2e-06
    EcKinase 208 e.ekeeefnvlnHGDlwvnNimfkydeegepedvilvDFQlsry 250
                 +  k  + + ++H D+ v Nimf+++ +    d++l+DF +s+y
  EFC38186.1 172 HaLKCIHNKGIVHCDVSVHNIMFRMKTS-CDFDAVLIDFNNSKY 214
                 34566678889**************866.667899******998 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   6.4e-05      0.16     164     196 ..     178     212 ..     128     215 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 6.4e-05
                 S-EEEE-SS-SGGGEEEC......TTEEEEE---TT- CS
         APH 164 lptvllHgDlhpgNllvd....pddgrvtGviDfeda 196
                   ++++H+D + +N++++     d + v  +iDf  +
  EFC38186.1 178 HNKGIVHCDVSVHNIMFRmktsCDFDAV--LIDFNNS 212
                 5789**************9887555667..9999766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (306 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1207  (0.0673211); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 1845.60
//
Query:       EFC38187.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-22   81.0  28.0    8.9e-21   74.9  25.3    3.8  2  Cyclin    Cyclin
    0.00011   21.9   0.1    0.00021   21.1   0.1    1.4  1  Cyclin_N  Cyclin, N-terminal domain


Domain annotation for each model (and alignments):
>> Cyclin  Cyclin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   2.4       0.3   2.7e+03      41      71 ..      30      60 ..       2      75 .. 0.48
   2 !   74.9  25.3   9.9e-25   8.9e-21      17     161 .]      89     258 ..      33     258 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.3
                ...............T--SS--SS-HHHHHH CS
      Cyclin 41 shtkttfaqtpkessFatkavpaisigsyls 71
                s+t tt+++     +  t +  a+s ++y s
  EFC38187.1 30 SSTTTTTNNGVAHTNNTTSVAAAVSSQAYSS 60
                3333333333333333444444444444443 PP

  == domain 2  score: 74.9 bits;  conditional E-value: 9.9e-25
                 HHH--------------T..............................................................T--SS--SS-HHHHHHHHH CS
      Cyclin  17 nndetatasadsksnlensqkqss.........................................shtkttfaqtpkessFatkavpaisigsylsrlq 74 
                 nn+ t+t+s++s+++++     ss                                         s+  +   + +++ +F+t ++p is+++yl r+ 
  EFC38187.1  89 NNNTTTTTSQSSSIPSST--TNSSttsttskdevipaklsqensyfglnqdefinafssviqeisSQGDMIPIEAQQKTQFHTSLPPRISLRKYLDRII 185
                 222233333333333333..2333345577777777777777777888888888888888877753334444445556678888889999999999985 PP

                 HHTT--HHHHHHHHHHHHHHHH..H-TT---STTTHHHHHHHHHHHHHHHH-SS---HHHHHHHHTS-HHHHHHHHHHHHHHTTT-- CS
      Cyclin  75 kfgesaplvllgtliYldrivkrcvsealvvtsanihRllivallvatKflvDlsysnekfakvggislkELnkLEidFlflvdFdl 161
                              l+Y+dr+v+   +  +v+ s++ihRlli++++va Kf++D +ysne++a++ggi+ +E+nkLEi+Fl +++F l
  EFC38187.1 186 ------------NLVYMDRLVQ--SNPNFVISSLSIHRLLITSIMVAAKFFDDKFYSNEYYANIGGIKKEEINKLEIEFLYMINFSL 258
                 ............699*******..9************************************************************86 PP

>> Cyclin_N  Cyclin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.1   2.3e-08   0.00021      56     126 ..     187     258 ..     183     259 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 2.3e-08
                 HHHHHHHHHHS.---CC..CHHHHHHHHHHHHHHHHSSS---HHHHHHHTTTSS-HHHHHHHHHHHHHHTTT-- CS
    Cyclin_N  56 vnyldRflskk.svpkd..klqlvgatcLllAaKveeisppkledlvyitdeafteeeilemErliLetLnfdl 126
                 ++y+dR+++++ ++  +   ++++ +t++++AaK+ +++  + e ++ i  + +++eei+++E ++L  +nf+l
  EFC38187.1 187 LVYMDRLVQSNpNFVISslSIHRLLITSIMVAAKFFDDKFYSNEYYANI--GGIKKEEINKLEIEFLYMINFSL 258
                 579*****976544333459******************98888877777..68*******************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1904  (0.106197); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 2061.83
//
Query:       EFC38188.1  [L=1372]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1372 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       830  (0.0462937); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.88u 0.33s 00:00:01.21 Elapsed: 00:00:00.52
# Mc/sec: 7910.41
//
Query:       EFC38189.1  [L=811]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.011   15.8   1.4      0.011   15.8   1.4    5.7  7  Speriolin_N  Speriolin N terminus


Domain annotation for each model (and alignments):
>> Speriolin_N  Speriolin N terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   1.2     0.049   8.8e+02     125     153 ..      77     111 ..      12     166 .. 0.51
   2 ?    0.6   0.0     0.028     5e+02      15      37 ..     229     251 ..     209     260 .. 0.79
   3 ?    1.2   0.8     0.018   3.3e+02      18      40 ..     303     332 ..     254     344 .. 0.77
   4 ?   -2.0   1.5      0.18   3.3e+03      17      39 ..     396     418 ..     374     438 .. 0.73
   5 ?   15.8   1.4   6.2e-07     0.011       7      47 ..     482     524 ..     478     539 .. 0.80
   6 ?   -2.0   0.2      0.18   3.2e+03      11      48 ..     593     631 ..     586     656 .. 0.59
   7 ?   -1.2   0.0       0.1   1.9e+03     161     191 ..     659     699 ..     618     705 .. 0.61

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.049
  Speriolin_N 125 l.....sdsv.persaaspgrtlasslglpseglL 153
                  l     +++v + +s+++ g+++a+ l   s+ +L
   EFC38189.1  77 LleingTNQVvSVPSNVGVGKEVAQPLASLSTPTL 111
                  13333322222444444444444444444444444 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.028
  Speriolin_N  15 erlvreNeeLKklvrllrenqel 37 
                  +   +eN++L +++ llr +  +
   EFC38189.1 229 DHYKSENSRLIQQLDLLRRDSDA 251
                  33449*************88765 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.018
  Speriolin_N  18 v.......reNeeLKklvrllrenqelkra 40 
                          reN++L+  + +l en + + +
   EFC38189.1 303 QselieckRENSKLRETIMVLEENIKKAEL 332
                  044446779**************9877666 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 0.18
  Speriolin_N  17 lvreNeeLKklvrllrenqelkr 39 
                  + r  e+LKk+ + +++n +  +
   EFC38189.1 396 IKRLEEDLKKQRESMKQNSNSSS 418
                  3367899****999999987655 PP

  == domain 5  score: 15.8 bits;  conditional E-value: 6.2e-07
  Speriolin_N   7 yegl.rhkierlvreNeeLKklvrllrenqelkra.Lgeasad 47 
                  ++++ r+ i+rlv eN eLK ++ l+ e+ e+ +  L  a+++
   EFC38189.1 482 FSVKsRKEIKRLVTENLELKNQLSLMNEQYEINKKqLQHATLE 524
                  677625679********************99855437778776 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 0.18
  Speriolin_N  11 rhkierlvreNeeLKklvrllre.nqelkraLgeasadr 48 
                  +hk+e++  e ++  k v+ lr  n el   L +a  dr
   EFC38189.1 593 QHKMEQMQLERSDGQKEVQYLRKrNSELETQLLNAESDR 631
                  566776666666666666655432555555544444443 PP

  == domain 7  score: -1.2 bits;  conditional E-value: 0.1
  Speriolin_N 161 gevavslssPllssTavklgvsqnllrsp..........la 191
                   + +v  s   + s  vkl++ q++ +++          l+
   EFC38189.1 659 NRKIVEQSRSSMQSIQVKLNRDQQIYQKSeydwnqkvkhLN 699
                  34566666666666667777777666666555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (811 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3948  (0.220202); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                       166  (0.00925874); expected 17.9 (0.001)
Passed Fwd filter:                        60  (0.00334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 2.17u 0.43s 00:00:02.60 Elapsed: 00:00:00.70
# Mc/sec: 3488.46
//
Query:       EFC38190.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      6e-13   48.9   8.8    9.2e-13   48.3   8.8    1.3  1  TM2       TM2 domain


Domain annotation for each model (and alignments):
>> TM2  TM2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.3   8.8   5.1e-17   9.2e-13       5      50 ..     126     170 ..     123     172 .. 0.96

  Alignments for each domain:
  == domain 1  score: 48.3 bits;  conditional E-value: 5.1e-17
         TM2   5 klvaylLwffLGglGvHRFYlGktgsGvlqlltfvGglgiwwlidl 50 
                  ++a++L++f G++G++RFYl ++  Gv++llt+ Gg g+ww++d+
  EFC38190.1 126 FVTALVLSVFAGIFGADRFYLQHIVLGVIKLLTL-GGVGVWWIVDI 170
                 689*******************************.*********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 1052.27
//
Query:       EFC38191.1  [L=324]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.21   11.5   0.6       0.69    9.8   0.1    1.8  2  DUF4252      Domain of unknown function (DUF4252)
       0.51   10.5   5.4        3.1    7.9   1.1    2.9  3  NADH_4Fe-4S  NADH-ubiquinone oxidoreductase-F iron-sulfur bin


Domain annotation for each model (and alignments):
>> DUF4252  Domain of unknown function (DUF4252)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.11     1e+03       3      19 ..      34      53 ..      32      74 .. 0.54
   2 ?    9.8   0.1   7.7e-05      0.69      11      85 ..     241     323 ..     233     324 .] 0.72

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.11
     DUF4252  3 illlllllllslpaaa...q 19
                +lll+l+l++  +aaa   +
  EFC38191.1 34 LLLLTLFLIFTSAAAAtlnC 53
                45555555555444443332 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 7.7e-05
     DUF4252  11 llslpaaa....qsaqaksldklfdkyednenvtsv.niskkmlkllsklddeeddk..elkellk...klksikvlttenkada 85 
                 +++l  +a       + k l+k+ d+y++ ++ +s+ ++++++ + l k+ ++++++  + +++l+    +k +++  ++nk+ +
  EFC38191.1 241 ITLL--YAlvncSCRSVKLLSKVVDDYKEGKEHESIrKLTQEFVSALEKVPENSNQEpnNHQQVLSprtTIKDVEMADLTNKKRN 323
                 2222..222243344668999******777777766379********9999988877889999*999999***999999977655 PP

>> NADH_4Fe-4S  NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   1.1   0.00035       3.1      14      36 ..     121     143 ..     115     161 .. 0.83
   2 ?    2.9   0.1     0.013   1.1e+02      16      32 ..     195     211 ..     193     228 .. 0.84
   3 ?   -1.4   0.0      0.29   2.6e+03      30      52 ..     256     278 ..     250     291 .. 0.57

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00035
                  --S--HHHHIIIIHHHHHHHHHT CS
  NADH_4Fe-4S  14 sCGkCtpCreGtkrllelleria 36 
                   CG+C+p  +Gt  ll+ ++  +
   EFC38191.1 121 QCGECIPGTSGTSNLLNSFQCAV 143
                  6*************999877655 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.013
                  S--HHHHIIIIHHHHHH CS
  NADH_4Fe-4S  16 GkCtpCreGtkrllell 32 
                  +kC+ C eG   ++  +
   EFC38191.1 195 HKCVSCSEGDVDMNTGV 211
                  59*******98887655 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.29
                  HHHHHHTBT---HHHHHHHHHHH CS
  NADH_4Fe-4S  30 elleriaagegteedldlleela 52 
                  +ll ++++ +++ ++ + +++l+
   EFC38191.1 256 KLLSKVVDDYKEGKEHESIRKLT 278
                  44445554444444445544444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (324 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1087  (0.060628); expected 358.6 (0.02)
Passed bias filter:                      627  (0.0349713); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 1907.77
//
Query:       EFC38192.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.063   12.9   0.3        7.8    6.1   0.0    2.2  2  DUF2529         Domain of unknown function (DUF2529)
       0.22   10.3   0.5        0.3    9.9   0.5    1.1  1  Androgen_recep  Androgen receptor


Domain annotation for each model (and alignments):
>> DUF2529  Domain of unknown function (DUF2529)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.1    0.0023        21      64     101 ..      42      80 ..      17     105 .. 0.75
   2 ?    6.1   0.0   0.00087       7.8       8      47 ..     262     300 ..     256     340 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0023
                 TTEEE-.-TT----TT-EEEEEES-S--HHHHHHHHHHH CS
     DUF2529  64 psvkkl.eeekeltetDrvllfsresndkealklakkle 101
                  +++   +ee+ + + Dr ++++ +++++e+ +  ++  
  EFC38192.1  42 DKMRSSsDEENIIINNDRAMIMTTQQQQQEIKQDKQQSI 80 
                 344443045558999*************99888777654 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.00087
                 HHHHHHHHH.HCCHHHHHHHHHHHHHHHHTT--EEEEE-G CS
     DUF2529   8 QLtGllkriqekeeesiedaarlLaqavigdgkvyikgfg 47 
                  L+ ++kri e+e  ++ d+  lL   v g   vy++g++
  EFC38192.1 262 YLMMIFKRI-EEEGIEVTDTMELLDEYVQGTDVVYLDGYQ 300
                 57789****.99999***********************96 PP

>> Androgen_recep  Androgen receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.5   3.4e-05       0.3     174     238 ..      47     107 ..      40     130 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 3.4e-05
  Androgen_recep 174 sadlkdil.aeastmqllqqqqqehhhqqhqhqqqqqqeaavvedsssgrareaagasasskdnyl 238
                     s+d  +i+  +  +m +  qqqq+     + +q++qq  +  ++ s++ r+r ++ +s  s  +y 
      EFC38192.1  47 SSDEENIIiNNDRAMIMTTQQQQQ-----EIKQDKQQSISERSATSNGRRSRSTSSSSLNSEYEYW 107
                     445555540445556555555554.....3445555566667788888999999999988887774 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1749  (0.0975515); expected 358.6 (0.02)
Passed bias filter:                      740  (0.0412739); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.36s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 2116.34
//
Query:       EFC38193.1  [L=1061]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      3e-11   43.3   0.4    7.2e-11   42.0   0.4    1.6  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
        5.1    7.5   7.9          1    9.7   1.2    2.5  2  DUF3852        Protein of unknown function (DUF3852)


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.0   0.4   8.1e-15   7.2e-11       6     156 ..     791     948 ..     789     967 .. 0.85

  Alignments for each domain:
  == domain 1  score: 42.0 bits;  conditional E-value: 8.1e-15
  Guanylate_cyc   6 ydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmleal.eevaves... 96 
                    ++++++l ++++ ++ + +  +p ++++lLn+++  + + ++++++  +k+  +a +++++ +  +  +h +++++ aL++++++ e ++++s   
     EFC38193.1 791 TQNMSVLCCELNPSEIFREM-KPSDLLDLLNDYFVLVCNATHNHGGLVDKFNTNALVCYFNEStFPVLNHEQNACSAALEIVNQIsELIEKHSkkt 885
                    67889999999888877775.5*************************************9877478999****************55555555666 PP

  Guanylate_cyc  97 keglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagk..iqvseetyellk 156
                    + +++++v +++G +++g++G + ++++ ++G++  +A  m ++ +++k  + + ++t +  +
     EFC38193.1 886 SSKISIKVSVNSGDIICGLLGsNTRMNFSMIGKNYDMAINMLQMNNHYKtkVLIGQNTLRKVR 948
                    79*******************9999****************9998876511555777776665 PP

>> DUF3852  Protein of unknown function (DUF3852)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   1.2   0.00011         1       7      87 ..     321     403 ..     315     410 .. 0.73
   2 ?    0.4   0.7     0.091   8.2e+02      42      67 ..     675     701 ..     663     716 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00011
     DUF3852   7 iillvvlilaallav.talAa.sgdvagaiestwkeaksqiktvvnnvvfpvidvilavllfvklatayldYrkhgqlefaap 87 
                  il++++i+  ++ + +++    +   +++++t +  + qikt  +n ++ ++d    ++   k ++a  d+  ++ql+++ +
  EFC38193.1 321 NILIILFIVQGIFGIiSSFILlYSSGESVLKQTESIQQIQIKTYSKNEILKIVDYTNLAVETIKFEMAESDFNINNQLHWTKL 403
                 4444444444444330333334455567899999999*****************98555566799***************975 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.091
     DUF3852  42 ksqiktvvnnvvfp.vidvilavllfv 67 
                 +s++k+  ++vv+  v++v++ v++f 
  EFC38193.1 675 ASKVKSFADEVVTGgVTSVVVFVIVFI 701
                 455666666666541333333333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1061 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2190  (0.122148); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.91u 0.31s 00:00:01.22 Elapsed: 00:00:00.51
# Mc/sec: 6315.46
//
Query:       EFC38194.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.078   12.5   0.0       0.14   11.7   0.0    1.4  1  Sigma70_r4  Sigma-70, region 4
        1.3    8.8   9.4       0.17   11.7   5.3    1.5  2  MAT1        CDK-activating kinase assembly factor MAT1


Domain annotation for each model (and alignments):
>> Sigma70_r4  Sigma-70, region 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   1.6e-05      0.14      23      45 ..     104     126 ..     101     128 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.6e-05
                 HHHHHHHHTS-HHHHHHHHHHHH CS
  Sigma70_r4  23 leEIgerlgiSrerVrqiekrAl 45 
                  + +++ ++iS++rV++i+++++
  EFC38194.1 104 ISSLSDSMDISKGRVKSIQSNGV 126
                 5678899************9875 PP

>> MAT1  CDK-activating kinase assembly factor MAT1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   5.3   1.8e-05      0.17      66     182 ..     123     243 ..     116     265 .. 0.59
   2 ?   -4.0   0.1       1.2   1.1e+04      70     105 ..     315     325 ..     308     332 .. 0.42

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.8e-05
        MAT1  66 TekkleqYekenkelIlknkeklkqeeeeleeleelekeekeekrkeekqeeeeekekke....kakeelideLatsskdaeeiiekvkkkakkkksse 160
                  +  l++Ye    e+I  ++ ++++e ++++  ++++  +++ek++    +++ e++kk+    + +e l +++  s ++ ++  ++ +++++++++s+
  EFC38194.1 123 SNGVLHSYEFWSNESIDFENCRQETEMQNIQMEIKMKSPKHSEKHDSDSLHHNPEHKKKKkyngWVEEPLSQSMHHSPSHHHSTHHSNNHHSTNHHHST 221
                 56678999999***********************99999999998877666666666666011144555555555555544444444444443332222 PP

        MAT1 161 kekleelnkelkkkatkfssgi 182
                 +++ ++ +++ +++++  s+ +
  EFC38194.1 222 HHHHASRHEHHHSNHSAHSTTT 243
                 2222222222333333222222 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 1.2
        MAT1  70 leqYekenkelIlknkeklkqeeeeleeleelekee 105
                 +e Yek+                          k++
  EFC38194.1 315 IELYEKSM-------------------------KQH 325
                 33333322.........................222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1939  (0.108149); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.36s 00:00:01.10 Elapsed: 00:00:00.54
# Mc/sec: 1864.38
//
Query:       EFC38195.1  [L=416]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-39  134.9   1.0    5.7e-39  134.4   1.0    1.2  1  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  134.4   1.0   3.2e-43   5.7e-39       1     208 [.     132     379 ..     132     380 .. 0.84

  Alignments for each domain:
  == domain 1  score: 134.4 bits;  conditional E-value: 3.2e-43
      DUF563   1 nnygHwlvdvlprlllleqlvlddd...drilvpalaspqpfqrellkllgi.rpekrikveldepvhveklivpvpprssggfqgallp......... 86 
                 n++ H + d++++ +++e++ l+++   ++il  ++++p +f+++    l + rp k+ +  ++  v++e++i++++++  ++ ++ +           
  EFC38195.1 132 NMF-HAMSDFFATHVVIEMFKLNSSniqIVILDEHFDGPFDFLWDKA--LSFkRPMKKASSFSNGMVRFERAIFQHAGYATHFLSNLMNFnendatmch 227
                 689.*********************7644444566666667777666..999999****999*****************55555555555777778888 PP

      DUF563  87 .......klrdrlrerlnlekr..kkp...trvlyisR.........lkagsRrilNeeevl.......kllpkrgfevvdpeslsfeeqiklfssakv 157
                        ++++r+++ l+++kr  + +   +rvl+isR         ++  sR+i+Neeevl       ++ +k+++e+vd+++l + eqi+ ++++++
  EFC38195.1 228 skiplvaNFANRILNGLGIKKReiN-KgdvIRVLFISRrpyvkfgveHNFMSRQISNEEEVLdrmkthrEYGKKFTVERVDFAHLKLVEQIQKVHDSDF 325
                 8999999**************9862.34699*******8776666655555**********988866655555666*********************** PP

      DUF563 158 ivgphGsgltnliFmpp.gttvielvppnrldns..fenlaallglkyayvlge 208
                 ++g+hG+glt++++mp+  ++v+e++++ + + +  fe+++ ++g++y+++ ++
  EFC38195.1 326 LIGYHGAGLTHSLWMPEeTSAVLEIWNTVTTRGWrcFEQFTFWKGNDYTLWSNS 379
                 ***************7747******99977777788**************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       718  (0.0400469); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.27s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2529.03
//
Query:       EFC38196.1  [L=277]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1649.12
//
Query:       EFC38197.1  [L=872]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.3e-43  143.2   5.4    3.1e-06   26.9   0.2   10.8 11  NHL           NHL repeat
    1.2e-08   34.9   0.4      0.048   13.2   0.0    5.1  5  SGL           SMP-30/Gluconolactonase/LRE-like region
    0.00013   22.1   2.9        7.9    6.8   0.0    5.9  6  Arylesterase  Arylesterase
  ------ inclusion threshold ------
      0.016   14.9   0.3      0.062   13.1   0.3    2.1  1  SprB          SprB repeat
      0.023   15.2   0.1      0.042   14.4   0.1    1.5  1  GPS           GPCR proteolysis site, GPS, motif


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0022         8       4      27 ..      22      46 ..      21      47 .. 0.92
   2 !   18.5   0.1   4.2e-07    0.0015       2      27 ..      78     103 ..      78     104 .. 0.93
   3 ?   -0.7   0.0       0.5   1.8e+03      11      23 ..     147     159 ..     137     162 .. 0.73
   4 !    9.8   0.0   0.00023      0.82      11      27 ..     252     268 ..     245     269 .. 0.88
   5 ?   -1.6   0.0      0.96   3.4e+03       6      20 ..     302     316 ..     302     321 .. 0.85
   6 !   10.5   0.0   0.00014      0.51       4      20 ..     354     370 ..     353     372 .. 0.94
   7 !   11.4   0.0   7.4e-05      0.27       1      27 [.     409     436 ..     409     437 .. 0.90
   8 !   13.6   0.1   1.5e-05     0.054       3      25 ..     454     475 ..     453     477 .. 0.92
   9 !   26.9   0.2   8.7e-10   3.1e-06       5      27 ..     512     534 ..     510     535 .. 0.94
  10 !   22.1   0.0     3e-08   0.00011       1      27 [.     564     591 ..     564     592 .. 0.95
  11 !   12.7   0.0   2.7e-05     0.098       2      27 ..     622     648 ..     621     649 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0022
                EEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL  4 PhGvavd.snGdiyVaDsenhrvqv 27
                P+ v  d ++ +iy++D+ n+r+++
  EFC38197.1 22 PTKVKFDrKSENIYISDRINNRIRK 46
                889999999**************87 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 4.2e-07
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n+P  v v+sn+diy aD++nhr+++
  EFC38197.1  78 NNPGKVEVSSNNDIYFADTNNHRIRK 103
                 689999******************86 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.5
                 TTTEEEEEECCCT CS
         NHL  11 snGdiyVaDsenh 23 
                 +   +y++D+ +h
  EFC38197.1 147 DEKILYITDTASH 159
                 55569****9988 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00023
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                 +++ +++aD++n+r+++
  EFC38197.1 252 TSNTLLIADYGNNRIRI 268
                 6899***********97 PP

  == domain 5  score: -1.6 bits;  conditional E-value: 0.96
                 EEEEETTTEEEEEEC CS
         NHL   6 GvavdsnGdiyVaDs 20 
                 Gv+ ++ G++y aD+
  EFC38197.1 302 GVSTSNEGEVYFADY 316
                 788999*****8886 PP

  == domain 6  score: 10.5 bits;  conditional E-value: 0.00014
                 EEEEEEETTTEEEEEEC CS
         NHL   4 PhGvavdsnGdiyVaDs 20 
                 P+Gvav+++G+++++Ds
  EFC38197.1 354 PRGVAVSTSGELFISDS 370
                 9***************7 PP

  == domain 7  score: 11.4 bits;  conditional E-value: 7.4e-05
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P+ +  + s+G+++ +Ds+n+rv++
  EFC38197.1 409 LNNPSALEFSsSSGELFLSDSHNFRVRK 436
                 68888999999***************97 PP

  == domain 8  score: 13.6 bits;  conditional E-value: 1.5e-05
                 SEEEEEEETTTEEEEEECCCTEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrv 25 
                 +PhG+a+  n+ +yVaDs ++rv
  EFC38197.1 454 RPHGIAL-YNDLVYVADSQSNRV 475
                 7******.6********999998 PP

  == domain 9  score: 26.9 bits;  conditional E-value: 8.7e-10
                 EEEEEETTTEEEEEECCCTEEEE CS
         NHL   5 hGvavdsnGdiyVaDsenhrvqv 27 
                 +Gv+v++nG++++aD++nhr+++
  EFC38197.1 512 SGVTVLPNGEVLIADTNNHRIRK 534
                 7********************86 PP

  == domain 10  score: 22.1 bits;  conditional E-value: 3e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P+++ v+  +G+i++ Ds+nhr+++
  EFC38197.1 564 LNSPTDIEVSpVSGEIIIVDSNNHRIRK 591
                 799***********************97 PP

  == domain 11  score: 12.7 bits;  conditional E-value: 2.7e-05
                 SSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvqv 27 
                 n P+ ++++  +G++y+aD+en r+++
  EFC38197.1 622 NTPTTLSISaFSGHVYIADYENRRIRK 648
                 566667777779***********9987 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.014        50       8      76 ..      28     105 ..      24     112 .. 0.63
   2 !   13.2   0.0   1.4e-05     0.048      92     165 ..      84     168 ..      78     225 .. 0.75
   3 !    3.9   0.0    0.0096        35      50     163 ..     307     439 ..     272     456 .. 0.68
   4 !    8.2   0.1   0.00046       1.7     132     218 ..     449     542 ..     434     547 .. 0.77
   5 ?    0.1   0.0      0.14   4.9e+02     139     211 ..     570     650 ..     552     663 .. 0.57

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.014
         SGL   8 deeegaLlwvDilgqrihrldpatgketvldtpesvGaiap........rkd.grlvvasksglalldlasgeletla 76 
                 d++++ ++ +D  ++ri +ld  +gk +++  +e +G+  +         ++ g++ v s++++++ d+++ ++++++
  EFC38197.1  28 DRKSENIYISDRINNRIRKLDVMSGKISTIVGNEFIGFSGDgqaatlahINNpGKVEVSSNNDIYFADTNNHRIRKVF 105
                 556677888888888888888888888886666655555552222211133356777777777777776666666655 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 1.4e-05
         SGL  92 vvdpdGrlwfGtmgdeeakgeev.........galyrldpdgk..........lervlddltipNGlawspdgktlYlaDsltrkiwaydvda 165
                  v++++ ++f + ++++ ++            +        g+          +  +  +++ p ++ +s+d+k lY++D++ ++i a ++++
  EFC38197.1  84 EVSSNNDIYFADTNNHRIRKVFAngtiltiagC--------GEfgfdleekspVPALEAKINYPKAVLLSSDEKILYITDTASHMIKALSFET 168
                 567777777777777776666436444444433........333333333456999999*****************************99865 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.0096
         SGL  50 kdgrlvvasksglalldlas........geletladeee.dekpllrfNDgvvdpdGrlwfGtmgdeeakgeev........galyrldpdgk...ler 128
                 ++g++++a   ++ ++ ++         g+l++l d     + +l ++  ++v+  G+l++ + + ++ ++ ++        g+ + l +      +  
  EFC38197.1 307 NEGEVYFADYARVSVVTINGlikhvagnGKLQYLGDGNLaTQSQLFKPRGVAVSTSGELFISDSAQDTIRKVSTegvintiaGGTFPLGGY-IqdgVDP 404
                 4477777777777777544444444444788888877333555777888888999999999988888888877765555555555554444.0344777 PP

         SGL 129 vlddltipNGlawspdgktlYlaDsltrkiwaydv 163
                 + + l+ p +l +s+ +  l+l Ds+++++ +++ 
  EFC38197.1 405 LNTFLNNPSALEFSSSSGELFLSDSHNFRVRKISK 439
                 88888889999999999999999999999988765 PP

  == domain 4  score: 8.2 bits;  conditional E-value: 0.00046
         SGL 132 dltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge........gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 +++i+   ++   ++ +Y+aDs  +++ ++d ++ + +l +    a  + ++         ++ G++v  +G+v +A  +++++++++ +G +i+
  EFC38197.1 449 HTSITRPHGIALYNDLVYVADSQSNRVIRVDKNDGSVTLIAGNGTAGYSGDGslatqaqlFNVSGVTVLPNGEVLIADTNNHRIRKVNLEG-IIQ 542
                 44444444444456799**************999999888777776666666779998886699**********************99999.455 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.14
         SGL 139 lawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge........gepDGlavDa.eGnvwvAvwgggkvvrfd 211
                 + +sp +  ++++Ds +++i ++d   + +++        l+ ++        ++p  l + a +G+v++A +++ ++++++
  EFC38197.1 570 IEVSPVSGEIIIVDSNNHRIRKIDSFGNISTIAGTGIA-SLSSHGklsiygslNTPTTLSISAfSGHVYIADYENRRIRKLE 650
                 55566666666666666666666665555544444433.3333333555555545666666666677777777776666654 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.036   1.3e+02      54      82 ..      20      48 ..      11      51 .. 0.83
   2 !    6.8   0.0    0.0022       7.9      53      80 ..     136     163 ..     126     169 .. 0.85
   3 ?   -3.1   0.0       2.6   9.4e+03      48      77 ..     346     374 ..     332     377 .. 0.67
   4 ?    0.8   0.1      0.16   5.7e+02      52      84 ..     451     481 ..     439     483 .. 0.75
   5 ?    4.1   0.0     0.014        52      26      78 ..     536     589 ..     527     594 .. 0.81
   6 ?    0.8   0.0      0.16   5.8e+02      52      81 ..     620     649 ..     609     653 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.036
  Arylesterase 54 ssanGInidadkkyiyvadilresihvmk 82
                   +++ +++d +   iy++d +++ i  ++
    EFC38197.1 20 LAPTKVKFDRKSENIYISDRINNRIRKLD 48
                  5799999****************997665 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0022
  Arylesterase  53 lssanGInidadkkyiyvadilresihv 80 
                   ++ +  + +++d+k++y++d   + i +
    EFC38197.1 136 INYPKAVLLSSDEKILYITDTASHMIKA 163
                   667888999************9999866 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.6
  Arylesterase  48 vvasglssanGInidadkkyiyvadilres 77 
                      s+l  + G+ +++    ++++d+ ++ 
    EFC38197.1 346 ATQSQLFKPRGVAVSTSGE-LFISDSAQDT 374
                   4446677899999988764.6788777665 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.16
  Arylesterase  52 glssanGInidadkkyiyvadilresihvmkkh 84 
                   +++ + GI +   +  +yvad+  + + +++k+
    EFC38197.1 451 SITRPHGIALY--NDLVYVADSQSNRVIRVDKN 481
                   45566777665..458*******9999888775 PP

  == domain 5  score: 4.1 bits;  conditional E-value: 0.014
  Arylesterase  26 llemslqlaw.tavvYyspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   +le ++q++  t++  ++++++    ++l+s++ I ++++   i + d+ ++ i
    EFC38197.1 536 NLEGIIQTIAgTGIPGFNGDNILATSAQLNSPTDIEVSPVSGEIIIVDSNNHRI 589
                   566666665513455689999999999**************9999999999988 PP

  == domain 6  score: 0.8 bits;  conditional E-value: 0.16
  Arylesterase  52 glssanGInidadkkyiyvadilresihvm 81 
                   +l++++ + i+a    +y+ad  ++ i  +
    EFC38197.1 620 SLNTPTTLSISAFSGHVYIADYENRRIRKL 649
                   68899****************988887655 PP

>> SprB  SprB repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.3   1.7e-05     0.062      11      29 ..     479     497 ..     471     497 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.7e-05
        SprB  11 ggndGsItvtvsGGtapYt 29 
                 + ndGs+t+ + +Gta+Y+
  EFC38197.1 479 DKNDGSVTLIAGNGTAGYS 497
                 78****************7 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.1   1.2e-05     0.042       2      44 ..     763     804 ..     762     805 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.2e-05
         GPS   2 sCvfWdeeneetgsWsteGC..eltesdnknetvCsCnHLtsFAv 44 
                 sC+ +   n+e ++W ++G   e+ + ++k  ++C+ + L+sFA+
  EFC38197.1 763 SCISY---NQESKEWKNDGSvnEILSLNSKLTISCKFSKLSSFAI 804
                 8****...55679******866556777899999**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (872 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       610  (0.0340231); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.75u 0.35s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 5088.86
//
Query:       EFC38198.1  [L=2604]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.7e-32  109.3 245.8     0.0016   18.8   9.7   16.1 16  EGF_2         EGF-like domain
    1.6e-16   60.2  28.5    6.4e-16   58.2  15.6    4.2  4  REJ           REJ domain
  ------ inclusion threshold ------
      0.014   15.8   1.0       0.49   10.9   0.0    3.5  3  SIT           SHP2-interacting transmembrane adaptor protein,


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   1.4       0.4   2.4e+03      22      32 .]     643     653 ..     643     653 .. 0.95
   2 !   14.8   9.5   4.7e-06     0.028       5      32 .]     666     692 ..     662     692 .. 0.87
   3 !   12.2  10.7   3.1e-05      0.19       8      32 .]     708     731 ..     701     731 .. 0.86
   4 !   17.7   6.2   5.8e-07    0.0035       4      32 .]     743     770 ..     738     770 .. 0.87
   5 !   16.1   9.7   1.8e-06     0.011       5      32 .]     783     809 ..     775     809 .. 0.89
   6 !   18.8   9.7   2.7e-07    0.0016       5      32 .]     822     848 ..     819     848 .. 0.91
   7 !   16.2  12.2   1.7e-06      0.01       4      32 .]     860     887 ..     857     887 .. 0.88
   8 !   13.1   6.6   1.5e-05     0.092       5      32 .]     900     926 ..     896     926 .. 0.87
   9 !   13.8   7.1   9.6e-06     0.057       5      32 .]    1086    1112 ..    1082    1112 .. 0.85
  10 !   16.5   8.5   1.3e-06    0.0081       6      32 .]    1212    1237 ..    1208    1237 .. 0.86
  11 !    9.4   7.2   0.00023       1.4       5      26 ..    1249    1269 ..    1242    1279 .. 0.77
  12 !   18.6   7.0   2.9e-07    0.0018       7      32 .]    1302    1330 ..    1296    1330 .. 0.88
  13 !   13.3  10.1   1.3e-05     0.079       4      32 .]    1342    1374 ..    1335    1374 .. 0.88
  14 ?   -1.8   0.1      0.69   4.1e+03      23      32 .]    1377    1386 ..    1376    1386 .. 0.94
  15 !    7.9  13.0   0.00066         4       1      32 []    1391    1419 ..    1386    1419 .. 0.78
  16 !   11.1  13.7   6.5e-05      0.39       5      32 .]    1438    1470 ..    1431    1470 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.4
       EGF_2  22 dCdsgyqGktC 32 
                 +Cd++y G++C
  EFC38198.1 643 ECDANYGGDYC 653
                 5********** PP

  == domain 2  score: 14.8 bits;  conditional E-value: 4.7e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G C + + +C C++g++G++C
  EFC38198.1 666 STVCNSNGNCTDVN-NCLCSNGFSGANC 692
                 678*******8677.8************ PP

  == domain 3  score: 12.2 bits;  conditional E-value: 3.1e-05
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 C+ hGtC +  + C C+s+y+G +C
  EFC38198.1 708 CSYHGTCTS-YNTCNCSSNYYGSNC 731
                 *******84.459************ PP

  == domain 4  score: 17.7 bits;  conditional E-value: 5.8e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s+e C g+G+C +    C+C++g++G++C
  EFC38198.1 743 SSEVCLGRGICAQVD-DCHCEFGFTGNNC 770
                 3789*******9445.7************ PP

  == domain 5  score: 16.1 bits;  conditional E-value: 1.8e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G C +++ +C+C+sg++G+ C
  EFC38198.1 783 SSVCSSRGLCLSPN-NCSCQSGFFGNEC 809
                 789********999.8************ PP

  == domain 6  score: 18.8 bits;  conditional E-value: 2.7e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+  G+C +++ +C C++gy+G+ C
  EFC38198.1 822 SQVCSSSGVCSSPN-NCTCNDGYTGDEC 848
                 678********999.8************ PP

  == domain 7  score: 16.2 bits;  conditional E-value: 1.7e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++  C+ghG C  + ++C C+sgy+G++C
  EFC38198.1 860 NSKVCSGHGGCS-FYNNCICESGYFGNDC 887
                 3789*******8.6889************ PP

  == domain 8  score: 13.1 bits;  conditional E-value: 1.5e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C      C+C+ +++G +C
  EFC38198.1 900 SSVCSGNGNCTMHD-TCECKESFTGLSC 926
                 689*******8555.8*********999 PP

  == domain 9  score: 13.8 bits;  conditional E-value: 9.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G C      C+C+ +++G +C
  EFC38198.1 1086 SSVCSGNGNCSMND-TCECKESFTGLSC 1112
                  689*******8444.7*********999 PP

  == domain 10  score: 16.5 bits;  conditional E-value: 1.3e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g+G+C +   qC+Cd gy G+ C
  EFC38198.1 1212 LVCSGNGKCLTNQ-QCSCDYGYAGDVC 1237
                  68*******9555.7**********99 PP

  == domain 11  score: 9.4 bits;  conditional E-value: 0.00023
       EGF_2    5 deiCgghGtCvnqcGqCdCdsg 26  
                  d  C+g+G+C n  + C+C+s 
  EFC38198.1 1249 DRVCNGRGVCSNI-NTCECFSR 1269
                  789*******844.59***985 PP

  == domain 12  score: 18.6 bits;  conditional E-value: 2.9e-07
       EGF_2    7 iCgghGtC.vnqcGq..CdCdsgyqGktC 32  
                   C++hG+C +++++   C+Cd gy+G++C
  EFC38198.1 1302 VCSNHGKCfIDLNNSsgCFCDYGYYGDSC 1330
                  7*******999996478************ PP

  == domain 13  score: 13.3 bits;  conditional E-value: 1.3e-05
       EGF_2    4 sdeiCgghGtCvnqcGqCdC.....dsgyqGktC 32  
                  s++ C+ghGtC+++   C+C     + ++ G++C
  EFC38198.1 1342 SENVCSGHGTCESPD-TCQClnddtNGHFAGPNC 1374
                  3899********999.9******9999999**99 PP

  == domain 14  score: -1.8 bits;  conditional E-value: 0.69
       EGF_2   23 CdsgyqGktC 32  
                  C s ++G +C
  EFC38198.1 1377 CHSAFSGSSC 1386
                  *********9 PP

  == domain 15  score: 7.9 bits;  conditional E-value: 0.00066
       EGF_2    1 CsasdeiCgghGtC.vnqcGqCdCdsgyqGktC 32  
                  C    ++C ++G+C +  ++qC+C s+++G  C
  EFC38198.1 1391 CT--ASTCLNGGSCgN--ENQCVCTSNFTGLIC 1419
                  44..579*******55..55*********9666 PP

  == domain 16  score: 11.1 bits;  conditional E-value: 6.5e-05
       EGF_2    5 deiCgghGtCvnqcGqCdC.....dsgyqGktC 32  
                  +++C+ghG C+ ++G C C     +  + G +C
  EFC38198.1 1438 ETTCNGHGFCDMLNGTCLCfssreNGYWNGTSC 1470
                  789****************77776667778877 PP

>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -10.3   9.8         3   1.8e+04     191     281 ..     972    1063 ..     914    1077 .. 0.51
   2 ?   -1.8   4.4      0.17   9.9e+02     391     441 ..    1152    1204 ..    1136    1214 .. 0.78
   3 !   18.4   4.9   1.2e-07   0.00073      91     243 ..    1607    1740 ..    1601    1763 .. 0.72
   4 !   58.2  15.6   1.1e-19   6.4e-16      42     442 ..    1764    2174 ..    1732    2181 .. 0.73

  Alignments for each domain:
  == domain 1  score: -10.3 bits;  conditional E-value: 3
         REJ  191 teqtilvvdgepplvsiecisncngkvnpndrlvllasclncakdlkdvtfeW.slsqtseeysllpdkatsslttgterprLvikenkLqs 281 
                  ++  i + +  + + s+  ++  n++    +   +  s+ln ++ + ++ f   ++   s+++s++ ++ t+  +   ++ + +i+   L++
  EFC38198.1  972 SSNYISLSNNTVNTTSLNDTEYFNETKMNPSNISITNSSLNYTSLNDTANFNEtKMNNDSSHNSTSNTNETDVNSPLLQQNTSTINNTILNN 1063
                  44444444444444444444444444444444444444555544333333322344444444444444444444444444445555555544 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.17
         REJ  391 vsVyDnkgarvsvsltitVkppavnns..tieellenrtrnenelskllesgd 441 
                  +s ++  + ++s + t tV + +vn+s   ++++ +n++ +++++s+ ++++ 
  EFC38198.1 1152 ISMTNGSSNYTSENSTFTVNETDVNSSpqNTSTIINNTNPTTSNTSSVMQNST 1204
                  34445555567999**************9999************999999865 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 1.2e-07
         REJ   91 ssrvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrs.. 185 
                  s++  + ++n++L +s+S+  d++     +l+Y+W++ +             +n + ++l+ + +s++ ++l++ +++l+++ t+ ++l v+ +   
  EFC38198.1 1607 SKKLYSTSENIYLSASNSFSGDKK-----GLEYYWSI-NG------------QNVPMNVLQ-STMSTKDQILKIEKDQLTSG-TFVISLFVKSQVsk 1683
                  67778889***********98776.....8*******.22............356666666.7888999*************.79999999888754 PP

         REJ  186 rksasteqtilvvdgepplvsiecisncngkvnpndrlvllasclncakd.lkdvt.feW 243 
                    s++ + ti+v+d e p v i    n++ +v+  d+++    +++++ +  ++ + +eW
  EFC38198.1 1684 LSSSTESITIQVQDVEFPSVVIL---NKEISVKSIDKYITIKKTTSIPISlKEKEMkIEW 1740
                  33455568999999999999886...4455777777766666677777664333334777 PP

  == domain 4  score: 58.2 bits;  conditional E-value: 1.1e-19
         REJ   42 ltippsfLpygtyvflltvslsgepsleatdiikvrvepspLvavIkGGssrvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnn 138 
                  l+i +      +yvf++++ + ++p+l+++d + ++ ++ +L   ++   + + + +++++++    +Dp+ + ++ + +  +W+c + + + g+ +
  EFC38198.1 1764 LSIGKW-----KYVFKVSIFVVENPTLTSNDFVVINADQPKLSLSLSL--KQSTRISNSIQVNF---QDPENNLDEYERW--KWTCIDVA-TVGYCG 1847
                  444444.....6777777777777777777777777777777777544..33344446777764...6888877777777..8***9998.667777 PP

         REJ  139 dnpllnidpealsgtllssstssltfpaselvanl.tynftltvskrsrksasteqtilvvdgepplvsiecisncngkvnpndrlvllas.clnca 233 
                  d+ ++++ + +++      ++ ++ ++++ + +++   ++tl + k++r s  ++  + ++++ p +  i++  n +  v   d+  ++       +
  EFC38198.1 1848 DT-IYQNLALNSK-----NRSTIINLSQQDFPSYVmSPTLTLFIMKGDR-SVYSSLNLNIQHSPPIISVISISPNLRNIVTNDDKISIEMKhQDQDP 1937
                  76.5666666666.....567799999999999998999**********.****************************************9555555 PP

         REJ  234 kdlkdvt.feW...slsqtseeysllpdkatsslttgterpr.................LvikenkLqsgesyaltl..rvtdkegkks..glasi. 304 
                  ++++ v   +W   +  ++ ++++++  +  ++++++                      Lvi+++ L++g++  + +  +++d  ++++  +++ + 
  EFC38198.1 1938 SNSSLVIkTQWkidNFLVSESNTKKVNGNEFETTSST----IttpfkhlkslnknkyssLVIDSKELEEGTDHSIEVkvSFVDSYTNQEmaATSNVn 2030
                  5566676899*77733333333333333112222222....123457778888888888**********9888888743444444444444333333 PP

         REJ  305 sfkvnepPtgGtcsvtPlegvaletaftvrCqgwtDkdqPLgYev...sysqrrasgpyrlly.egsnn.isisviLPvGppqq.dykvtvmvsVyD 395 
                  sf+   pP+++ c++ P++gv+++t+ft++C++ +++d+     +   +++q +  + y  l+  gs n  s+s+ +++ ++   d++v+++v+  D
  EFC38198.1 2031 SFTKALPPRKCPCTISPTTGVSMKTDFTFSCDNCQNEDNTIE--IkqgYIDQETGIKVYLPLSlDGSVNiPSSSSATSSTKRRLdDHSVQLFVELGD 2125
                  577788****************************99998444..45477888888887777753677776677778888888778************ PP

         REJ  396 nkgarv.svsltitVkppavnnstieellenrtrnene.lskllesgdt 442 
                  +    + ++  +itV pp+    t++e+l++ ++++++ +s+ ++ g+t
  EFC38198.1 2126 KSTGESrVMYSNITVLPPSPPHPTLSEILNLVSNQTSKiMSTSIQDGNT 2174
                  9988888***********************9998888735777777776 PP

>> SIT  SHP2-interacting transmembrane adaptor protein, SIT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.25   1.5e+03      48      69 ..     932     955 ..     925     993 .. 0.78
   2 ?    0.0   0.0      0.19   1.1e+03      48      70 ..    1118    1142 ..    1107    1175 .. 0.72
   3 ?   10.9   0.0   8.2e-05      0.49      10      50 ..    2550    2591 ..    2537    2596 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.25
         SIT  48 q..PieddicYanLnlqqtgtspe 69 
                 q  Pi ++i+++n++ + t+ ++ 
  EFC38198.1 932 QnsPIISNISFGNITFNNTSMNET 955
                 345999*********998864443 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.19
         SIT   48 q..PieddicYanLnlqqtgtspes 70  
                  q  Pi ++i+++n++ + t+ ++ s
  EFC38198.1 1118 QnsPIISNISFGNITFNNTSMNETS 1142
                  345999*********9998744443 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 8.2e-05
         SIT   10 lLlllviasllawrmkkrqkkaaeysseq.isredeevlqPi 50  
                   L +++++ ++a+ mkk++kk + y+ ++ is++ e+ + P 
  EFC38198.1 2550 ILSISMVMGIFACYMKKKSKKIYPYERKElISHNIEQPTKPY 2591
                  36799********************99998877777666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2604 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1465  (0.0817112); expected 358.6 (0.02)
Passed bias filter:                      307  (0.0171231); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.22u 0.30s 00:00:01.52 Elapsed: 00:00:00.53
# Mc/sec: 14747.92
//
Query:       EFC38199.1  [L=4502]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-58  194.5 431.5    6.6e-05   23.2   6.7   27.9 27  EGF_2     EGF-like domain
    5.5e-44  146.1  13.9    6.3e-05   22.8   0.0   18.0 17  NHL       NHL repeat
    1.1e-24   87.1  15.4    1.3e-17   63.8   5.8    2.4  2  REJ       REJ domain
  ------ inclusion threshold ------
      0.033   14.3   0.1       0.12   12.5   0.1    1.9  1  DsrH      DsrH like protein


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   7.4   2.6e-06     0.012       7      32 .]     498     521 ..     494     521 .. 0.89
   2 !   18.0   7.0   6.4e-07    0.0029       4      32 .]    1204    1231 ..    1201    1231 .. 0.91
   3 !   14.9   9.7   5.8e-06     0.026       5      32 .]    1908    1934 ..    1904    1934 .. 0.87
   4 !   15.7   9.2   3.1e-06     0.014       7      32 .]    2255    2279 ..    2250    2279 .. 0.90
   5 !   23.2   6.7   1.5e-08   6.6e-05       6      32 .]    2294    2319 ..    2288    2319 .. 0.88
   6 !   10.8  12.7   0.00011       0.5       5      32 .]    2332    2358 ..    2328    2358 .. 0.88
   7 !   19.5   6.7   2.1e-07   0.00092       5      32 .]    2371    2397 ..    2366    2397 .. 0.88
   8 !    9.8   9.8   0.00022      0.98       6      32 .]    2734    2759 ..    2730    2759 .. 0.86
   9 !   17.5  10.9   8.9e-07     0.004       5      32 .]    2771    2797 ..    2764    2797 .. 0.84
  10 !   15.7  11.3   3.3e-06     0.015       5      32 .]    2810    2836 ..    2804    2836 .. 0.88
  11 !   16.7   7.6   1.6e-06    0.0071       5      32 .]    2849    2875 ..    2845    2875 .. 0.91
  12 !   14.2   9.5   9.6e-06     0.043       7      32 .]    2890    2914 ..    2885    2914 .. 0.93
  13 !   10.7   6.8   0.00012      0.53       6      32 .]    2928    2953 ..    2924    2953 .. 0.90
  14 !   16.7   8.4   1.6e-06    0.0072       6      32 .]    2967    2992 ..    2963    2992 .. 0.91
  15 !    5.9  10.2    0.0038        17       5      32 .]    3005    3032 ..    2997    3032 .. 0.89
  16 !   10.4   6.8   0.00015      0.66       4      32 .]    3044    3071 ..    3041    3071 .. 0.86
  17 !   19.8  10.2   1.7e-07   0.00077       5      32 .]    3084    3110 ..    3076    3110 .. 0.89
  18 !   15.5   6.4   3.7e-06     0.016       5      32 .]    3123    3149 ..    3119    3149 .. 0.89
  19 !   21.9  10.8   3.6e-08   0.00016       5      32 .]    3162    3188 ..    3158    3188 .. 0.91
  20 !    9.9   9.3   0.00022      0.97       5      32 .]    3201    3227 ..    3193    3227 .. 0.87
  21 !   10.7   9.0   0.00012      0.53       5      32 .]    3240    3266 ..    3234    3266 .. 0.87
  22 !   15.0   6.6   5.3e-06     0.024       5      32 .]    3279    3309 ..    3273    3309 .. 0.90
  23 !    8.6   6.0   0.00052       2.3       4      32 .]    3326    3358 ..    3323    3358 .. 0.85
  24 ?    4.1   9.2     0.013        60       6      32 .]    3372    3402 ..    3368    3402 .. 0.82
  25 !    5.2   8.1    0.0061        28       1      27 [.    3420    3443 ..    3420    3446 .. 0.78
  26 ?    2.1   1.7     0.059   2.6e+02      22      32 .]    3455    3465 ..    3449    3465 .. 0.89
  27 !   10.8   6.2   0.00011      0.51       6      32 .]    4119    4143 ..    4116    4143 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 2.6e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+G+C+n   +C C+ g+ G +C
  EFC38199.1 498 VCSGRGSCINH--NCICKEGFEGEKC 521
                 6*******944..5************ PP

  == domain 2  score: 18.0 bits;  conditional E-value: 6.4e-07
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C+ +G+C ++   C C++g++G +C
  EFC38199.1 1204 DQNVCSTNGKCSALD-TCICNFGWSGVKC 1231
                  5899********999.9************ PP

  == domain 3  score: 14.9 bits;  conditional E-value: 5.8e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +C+g+G Cv +   C C+ gy+G +C
  EFC38199.1 1908 NRACSGRGECVGLD-ACNCFGGYSGIKC 1934
                  789********666.7************ PP

  == domain 4  score: 15.7 bits;  conditional E-value: 3.1e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +C+ +G+Cv+++  C C++++ G++C
  EFC38199.1 2255 ACSSNGQCVAEN-TCNCNDNWGGDDC 2279
                  7*******9777.9************ PP

  == domain 5  score: 23.2 bits;  conditional E-value: 1.5e-08
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ghG C++ +  C+Cd+g++G++C
  EFC38199.1 2294 TVCSGHGLCIDHN-TCRCDTGWSGADC 2319
                  67*******8666.9************ PP

  == domain 6  score: 10.8 bits;  conditional E-value: 0.00011
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C g+G+Cv ++ qC+C++g++  +C
  EFC38199.1 2332 SSVCYGNGQCVGFN-QCSCNNGWSDFDC 2358
                  688********777.********98888 PP

  == domain 7  score: 19.5 bits;  conditional E-value: 2.1e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  d+ C+g+G+C++    C+C  gyqG++C
  EFC38199.1 2371 DSSCSGNGKCISND-TCECYLGYQGPDC 2397
                  678*******9555.8************ PP

  == domain 8  score: 9.8 bits;  conditional E-value: 0.00022
       EGF_2    6 eiCgghGtCvnqcG..qCdCdsgyqGktC 32  
                  + C+g G+C    G  +C C sg+ G  C
  EFC38199.1 2734 NVCNGKGVCY---GvdKCNCTSGWNGTFC 2759
                  68*******9...4238***********9 PP

  == domain 9  score: 17.5 bits;  conditional E-value: 8.9e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+ +G+C++ +  C+C++g++G  C
  EFC38199.1 2771 KLACSSNGQCISNN-TCSCNDGWFGSIC 2797
                  789*******9555.9*********988 PP

  == domain 10  score: 15.7 bits;  conditional E-value: 3.3e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+g+G+C++ +  C+Cd+ y Gk+C
  EFC38199.1 2810 SNTCSGNGQCIANN-TCSCDNFYEGKNC 2836
                  799*******9555.9************ PP

  == domain 11  score: 16.7 bits;  conditional E-value: 1.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G Cv++   C C sgy+G++C
  EFC38199.1 2849 SLVCSGNGLCVSPD-TCNCTSGYFGNDC 2875
                  789********999.9************ PP

  == domain 12  score: 14.2 bits;  conditional E-value: 9.6e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+  G C +++  C+C+ gy+G++C
  EFC38199.1 2890 VCSSKGNCTAPN-TCFCEKGYYGNQC 2914
                  7********999.9************ PP

  == domain 13  score: 10.7 bits;  conditional E-value: 0.00012
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++C+ +G+C++   +C+C + ++G +C
  EFC38199.1 2928 NACSSRGSCIDID-KCKCGDDFYGSNC 2953
                  58*******8666.************* PP

  == domain 14  score: 16.7 bits;  conditional E-value: 1.6e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++C+g G C n++  C C++gy G  C
  EFC38199.1 2967 NTCSGKGDCLNPN-TCICNDGYAGERC 2992
                  79*******9999.9***********9 PP

  == domain 15  score: 5.9 bits;  conditional E-value: 0.0038
       EGF_2    5 deiCgghGtCvnqcGqCdC.dsgyqGktC 32  
                  ++ C  hG Cv++  +C C + +++G++C
  EFC38199.1 3005 SNVCDSHGECVSLD-NCTCtSLHHYGDNC 3032
                  689********999.8***999999**** PP

  == domain 16  score: 10.4 bits;  conditional E-value: 0.00015
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C+ hG C  +   C C+ gy G +C
  EFC38199.1 3044 NSSVCSSHGNCTFLD-ICNCSKGYEGLSC 3071
                  3789*******8555.9*********999 PP

  == domain 17  score: 19.8 bits;  conditional E-value: 1.7e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++iC+g+G+C  ++  C C++gy+G++C
  EFC38199.1 3084 SDICSGNGICTGPN-ICNCKDGYFGDDC 3110
                  689********888.9************ PP

  == domain 18  score: 15.5 bits;  conditional E-value: 3.7e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ +G C+++   C+C++gy+G  C
  EFC38199.1 3123 SSVCSSNGRCISLD-SCSCSFGYYGEMC 3149
                  789********999.7*********998 PP

  == domain 19  score: 21.9 bits;  conditional E-value: 3.6e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C++hGtC +++ +C C++gy+G++C
  EFC38199.1 3162 TSVCSQHGTCHSPN-NCTCNDGYHGADC 3188
                  578*******9999.8************ PP

  == domain 20  score: 9.9 bits;  conditional E-value: 0.00022
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ +G+C  ++ +C+C   ++G +C
  EFC38199.1 3201 SSVCSSRGYCKLPN-VCSCTGTFYGENC 3227
                  689*******9555.************9 PP

  == domain 21  score: 10.7 bits;  conditional E-value: 0.00012
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG+C+ +   C+C +gy   +C
  EFC38199.1 3240 SNVCSSHGKCIGAD-ACQCYDGYISSNC 3266
                  689********555.7*******99999 PP

  == domain 22  score: 15.0 bits;  conditional E-value: 5.3e-06
       EGF_2    5 deiCgghGtCvnqcGqCdC....dsgyqGktC 32  
                  ++ C+ghG+C +++ +CdC    d+++ G  C
  EFC38199.1 3279 SSVCRGHGYCTSPN-KCDCisnqDTKFDGQEC 3309
                  578********999.****9999999999999 PP

  == domain 23  score: 8.6 bits;  conditional E-value: 0.00052
       EGF_2    4 sdeiCgghGtCvnqcG......qCdCdsgyqGktC 32  
                  +++ C+g G+C    +      +C+C+ +y G +C
  EFC38199.1 3326 NNSVCSGSGVCK--LNrvmkrsECVCSENYGGESC 3358
                  4899*******9..776777666**********99 PP

  == domain 24  score: 4.1 bits;  conditional E-value: 0.013
       EGF_2    6 eiCgghGtCvnqcGqCdC.....dsgyqGktC 32  
                  ++C+++G C +    C+C     +  + G +C
  EFC38199.1 3372 SACNNNGFCSSVD-TCEChhndfFGYWKGSNC 3402
                  68*******8666.7****9987788889888 PP

  == domain 25  score: 5.2 bits;  conditional E-value: 0.0061
       EGF_2    1 CsasdeiCgghGtCvnqcG.qCdCdsgy 27  
                  C a  + C+++G+C+  +   C C+s+ 
  EFC38199.1 3420 CNA--SVCHNNGICD--EYmTCICNSNQ 3443
                  654..58********..6626***9975 PP

  == domain 26  score: 2.1 bits;  conditional E-value: 0.059
       EGF_2   22 dCdsgyqGktC 32  
                  +C+ gy+Gk C
  EFC38199.1 3455 VCQEGYYGKEC 3465
                  7********** PP

  == domain 27  score: 10.8 bits;  conditional E-value: 0.00011
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g G+ +  +G+C+Cd+gy+  +C
  EFC38199.1 4119 SVCNGKGVLN--NGKCQCDNGYSSFDC 4143
                  57*9999999..***********9999 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.2   1.3e-07   0.00058       1      25 [.     266     291 ..     266     292 .. 0.95
   2 !   11.3   0.0   6.4e-05      0.29       1      25 [.     326     351 ..     326     353 .. 0.92
   3 !   22.8   0.0   1.4e-08   6.3e-05       1      27 [.     384     410 ..     384     411 .. 0.94
   4 ?   -2.7   0.1       1.7   7.5e+03       6      17 ..     445     456 ..     444     457 .. 0.86
   5 ?    3.6   0.1     0.017        77      11      23 ..    1364    1376 ..    1362    1379 .. 0.88
   6 !    8.4   0.0   0.00051       2.3       3      25 ..    1412    1433 ..    1410    1434 .. 0.87
   7 ?    0.3   0.0      0.19   8.4e+02       4      16 ..    1645    1657 ..    1644    1661 .. 0.89
   8 ?    2.5   0.0     0.039   1.7e+02       3      21 ..    1694    1712 ..    1692    1713 .. 0.84
   9 ?   -0.3   0.0      0.29   1.3e+03       3      28 .]    1962    1986 ..    1960    1986 .. 0.71
  10 !    7.6   0.0   0.00096       4.3       1      23 [.    2016    2037 ..    2016    2041 .. 0.90
  11 ?    4.0   0.0     0.013        57      15      27 ..    2111    2123 ..    2109    2124 .. 0.89
  12 !   10.3   0.0   0.00013      0.59       1      28 []    2138    2165 ..    2138    2165 .. 0.94
  13 !   12.6   0.0   2.5e-05      0.11       1      27 [.    2420    2446 ..    2420    2447 .. 0.91
  14 !   16.4   0.1   1.5e-06    0.0068       2      27 ..    2478    2503 ..    2478    2504 .. 0.95
  15 ?    3.9   0.0     0.013        60       2      26 ..    2559    2584 ..    2558    2586 .. 0.84
  16 ?    3.6   0.0     0.017        75       2      23 ..    2615    2636 ..    2614    2639 .. 0.92
  17 ?    4.3   0.0     0.011        47       2      27 ..    2674    2698 ..    2673    2699 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 1.3e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrv 25 
                 +n+P+Gv v+ +++ +yVaD++n+ +
  EFC38199.1 266 LNDPQGVDVSfDGDFVYVADTGNNLI 291
                 799********************988 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 6.4e-05
                 BSSEEEEEEE.TTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrv 25 
                 +n+P +v+ + ++G+iy+a+ +nh +
  EFC38199.1 326 LNRPVSVRFSkKTGEIYIAEKGNHVI 351
                 79**********************55 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 1.4e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P+++a++++G iy+aDs+n+rv++
  EFC38199.1 384 LSEPSDIAISTSGVIYIADSGNNRVRK 410
                 679**********************86 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 1.7
                 EEEEETTTEEEE CS
         NHL   6 GvavdsnGdiyV 17 
                 +v v+ nG++++
  EFC38199.1 445 SVDVNENGELVI 456
                 699*******98 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.017
                  TTTEEEEEECCCT CS
         NHL   11 snGdiyVaDsenh 23  
                   +G +y+ Ds+nh
  EFC38199.1 1364 EDGSLYIVDSGNH 1376
                  58*********** PP

  == domain 6  score: 8.4 bits;  conditional E-value: 0.00051
                  SEEEEEEETTTEEEEEECCCTEE CS
         NHL    3 yPhGvavdsnGdiyVaDsenhrv 25  
                  +P+ + v +++ +y+aDs+n r+
  EFC38199.1 1412 SPRAIKV-TSNGVYIADSGNYRI 1433
                  6888999.6************98 PP

  == domain 7  score: 0.3 bits;  conditional E-value: 0.19
                  EEEEEEETTTEEE CS
         NHL    4 PhGvavdsnGdiy 16  
                  P G+a++s+G++y
  EFC38199.1 1645 PKGIALSSTGELY 1657
                  99*********99 PP

  == domain 8  score: 2.5 bits;  conditional E-value: 0.039
                  SEEEEEEETTTEEEEEECC CS
         NHL    3 yPhGvavdsnGdiyVaDse 21  
                  +P+ + ++s +++y+aDs+
  EFC38199.1 1694 NPTAIFINSKDELYIADSY 1712
                  67778899*********97 PP

  == domain 9  score: -0.3 bits;  conditional E-value: 0.29
                  SEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL    3 yPhGvavdsnGdiyVaDsenhrvqvF 28  
                   P  ++v ++  iyV+Dse + v+ F
  EFC38199.1 1962 KPGNLVV-DSEYIYVSDSEDNVVKRF 1986
                  5556666.57779*****98877665 PP

  == domain 10  score: 7.6 bits;  conditional E-value: 0.00096
                  BSSEEEEEEETTTEEEEEECCCT CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenh 23  
                  +n+P G++v  n+++++aD++n+
  EFC38199.1 2016 LNSPLGLSV-YNNELFIADFNNS 2037
                  799******.6***********7 PP

  == domain 11  score: 4.0 bits;  conditional E-value: 0.013
                  EEEEECCCTEEEE CS
         NHL   15 iyVaDsenhrvqv 27  
                  ++VaD++n+++++
  EFC38199.1 2111 LLVADTNNNSIKK 2123
                  79********986 PP

  == domain 12  score: 10.3 bits;  conditional E-value: 0.00013
                  BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28  
                  +n+P G+ +ds Gd+y+aDs+++++ ++
  EFC38199.1 2138 LNSPKGLFIDSFGDLYIADSGSNQILKY 2165
                  78999********************987 PP

  == domain 13  score: 12.6 bits;  conditional E-value: 2.5e-05
                  BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenhrvqv 27  
                  +n P Gv+v+s+Gdiy +D+ n+ +++
  EFC38199.1 2420 LNKPKGVTVSSSGDIYFSDTSNNKLKK 2446
                  799****************99998765 PP

  == domain 14  score: 16.4 bits;  conditional E-value: 1.5e-06
                  SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL    2 nyPhGvavdsnGdiyVaDsenhrvqv 27  
                  n+P G+ ++ nG++y aDs+n+rv++
  EFC38199.1 2478 NNPIGLDITENGEVYFADSNNNRVRK 2503
                  68**********************97 PP

  == domain 15  score: 3.9 bits;  conditional E-value: 0.013
                  SSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL    2 nyPhGvavd.snGdiyVaDsenhrvq 26  
                  n P G+ +  ++  +y++D  nh ++
  EFC38199.1 2559 NTPFGIDIGyQGKIVYITDKSNHVIR 2584
                  667799999999**********9665 PP

  == domain 16  score: 3.6 bits;  conditional E-value: 0.017
                  SSEEEEEEETTTEEEEEECCCT CS
         NHL    2 nyPhGvavdsnGdiyVaDsenh 23  
                  n+P G++v++++ i+ +Ds nh
  EFC38199.1 2615 NNPMGISVTNGNSIIFSDSSNH 2636
                  7899*****************9 PP

  == domain 17  score: 4.3 bits;  conditional E-value: 0.011
                  SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL    2 nyPhGvavdsnGdiyVaDsenhrvqv 27  
                  n P +v v +   iy+aD++ + +++
  EFC38199.1 2674 NTPGDVFV-NEKGIYIADTNDNAIRI 2698
                  56777777.6999*******999986 PP

>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   2.0   1.7e-10   7.8e-07      91     318 ..    3575    3773 ..    3563    3786 .. 0.80
   2 !   63.8   5.8   2.9e-21   1.3e-17     159     402 ..    3827    4058 ..    3789    4086 .. 0.80

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 1.7e-10
         REJ   91 ssrvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrsrk 187 
                  s + +g  +++++dGs+Sy pd ++     ls++W++++s             ni + ++   + s++ s+l++++s+   ++ + f l+v+ +  +
  EFC38199.1 3575 SNKLVGSCDSIIIDGSKSYSPDSKP-----LSFSWKVVNSP------------NINSLQHI--VQSQTRSILSIDSSNCSTGV-HIFELIVKSSILE 3651
                  567788889************9887.....88*****7777............22222222..4467779************6.99*****999988 PP

         REJ  188 sasteqtilvvdgepplvsiecisncngkvnpndrlvllas..clncakdlkdvtfeWslsqtseeysllpdkatsslttgterprLvikenkLqsg 282 
                   +s   ti +++ e+pl +i++ ++ + ++  +  + +  s   ++ca++l ++ + W        + ++ +  ++   + ++  +Lvi  n++ ++
  EFC38199.1 3652 LQSIPLTISITKAEIPLPTISIDAQASPLTTSKLPYKIMKStvLPDCAQSL-SMIYNW--------KLVSGR--NDIVFEMDQFNNLVII-NYFLED 3736
                  9***************99999999999888888887777665578998766.5779**........444555..7888888888999996.666677 PP

         REJ  283 esyaltlrvtdkegkks.glasisfkvnepPtgGtcs 318 
                  +sy++  +v ++  +++  ++++sf++   P + ++ 
  EFC38199.1 3737 SSYEFECSVFVEGHAENiITSKVSFSTKISPLSSEIR 3773
                  8999998777777666668899999999988877665 PP

  == domain 2  score: 63.8 bits;  conditional E-value: 2.9e-21
         REJ  159 tssltfpaselvanltynftltvskrsrksasteqtilvvdgepplvsiecisncngkvnpndrlvllasclncakdlkdvt.feWslsqtseeysl 254 
                  +s + ++ s l  + ++ ++ t++k++r s+s  +++  ++  pp++s    s  n  +  +  l + +   + + d++++   +W    t +  ++
  EFC38199.1 3827 NSEFLISGSLLSNYNNISLKSTIKKGKRISNSELVVTIPQKTLPPIISPVYLSPSNLALGSSINLQFGVT-IDGSDDISSAIsRKW----TLN--NV 3916
                  5667788888888889****************9999999**********999998888888877666554.4444456666669**....333..36 PP

         REJ  255 lpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaftvrCqgwtDkdqPLgYevsy 351 
                  + +k  s   + +e+  L + +n + +g++y++  +vtd + ++ +  s+sf++   P ++tc++ P++g+al+t ft++C++ ++++ PL++e+  
  EFC38199.1 3917 VIEKSDSMRLDPSESNSLILATNSFTEGATYKIDFKVTDQRNNQFSIYSYSFSIKISP-KCTCTISPSSGYALQTLFTFACTDCKNNQGPLSFEY-G 4011
                  66667777777777788**********************9999999***********9.6***********************************.7 PP

         REJ  352 sqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarv.s 402 
                  + +++++   +l++ s+    s++LP+ ++  ++++ ++++V+D+ + ++  
  EFC38199.1 4012 FIDSRYQTRVTLSKSSKY---SAVLPSSYQ--GNTLNLYAVVSDSVSQSSsY 4058
                  777777755556665555...******999..889*********99888733 PP

>> DsrH  DsrH like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   2.8e-05      0.12      12      55 ..     553     595 ..     546     597 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.8e-05
                 HHHT--TT-EEEE-GGGGGGGBTTBTTHHHHHTSSSEEEEEHHH CS
        DsrH  12 clrllqegDavlLieDgVyaalkgsrllkalkeasvklyaLkeD 55 
                  l++ ++gD ++L +Dg++  l g++l k  +++ ++l+ L+eD
  EFC38199.1 553 HLQVSNTGDMIVLTQDGILGRLVGNSLVKVSQSS-LALFYLEED 595
                 578999******************9988866666.********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (4502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       721  (0.0402142); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.77u 0.36s 00:00:02.13 Elapsed: 00:00:00.61
# Mc/sec: 22115.63
//
Query:       EFC38200.1  [L=1514]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.9e-25   87.1 142.3    0.00048   20.4   3.2   11.9 11  EGF_2         EGF-like domain
    4.6e-23   80.0   0.6    2.1e-05   24.3   0.0    7.2  6  NHL           NHL repeat
    1.1e-19   70.6  10.7    2.5e-19   69.4  10.7    1.5  1  REJ           REJ domain
    2.9e-05   24.3 128.0      0.089   13.1   2.0   12.7 12  EGF           EGF-like domain
    0.00029   20.5   0.3          5    6.6   0.0    3.7  4  SGL           SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.029   15.3   2.8      0.066   14.2   2.8    1.6  1  DUF4834       Domain of unknown function (DUF4834)
       0.03   14.5   0.4       0.69   10.1   0.0    2.9  3  Arylesterase  Arylesterase
      0.044   13.7   0.5        0.1   12.5   0.5    1.6  1  TMEM154       TMEM154 protein family
        1.8    7.8   4.3       0.77    9.1   1.3    1.8  2  DAG1          Dystroglycan (Dystrophin-associated glycoprotei


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   3.2   2.4e-07   0.00048       7      32 .]     370     394 ..     366     394 .. 0.90
   2 !   15.8   7.5   6.6e-06     0.013       7      32 .]     409     433 ..     404     433 .. 0.92
   3 !   17.4   6.5   2.1e-06    0.0042       5      32 .]     446     472 ..     442     472 .. 0.89
   4 !   17.0   8.8   2.8e-06    0.0056       5      32 .]     485     511 ..     481     511 .. 0.89
   5 !   13.3   6.6   4.1e-05     0.081       7      32 .]     526     550 ..     522     550 .. 0.92
   6 !   15.0   7.0   1.2e-05     0.024       7      32 .]     565     589 ..     560     589 .. 0.92
   7 !   13.0   7.8   5.1e-05       0.1       5      32 .]     602     628 ..     598     628 .. 0.89
   8 !   13.4   6.3   3.8e-05     0.076       7      32 .]     643     667 ..     638     667 .. 0.92
   9 !   15.1   7.2   1.1e-05     0.023       7      32 .]     682     706 ..     677     706 .. 0.92
  10 ?    5.4   0.5     0.012        24       7      15 ..     721     729 ..     716     732 .. 0.83
  11 ?    1.6   3.2      0.18   3.6e+02       6      32 .]    1105    1131 ..    1101    1131 .. 0.81

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 2.4e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ghG+C  ++ +C C++gy G  C
  EFC38200.1 370 VCSGHGICY-LTDVCTCNPGYIGSLC 394
                 5*******7.5779**********99 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 6.6e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +C+ghG+C+ ++  C C +gy G  C
  EFC38200.1 409 ACNGHGICEGPN-ICNCTTGYVGSFC 433
                 6********888.9***********9 PP

  == domain 3  score: 17.4 bits;  conditional E-value: 2.1e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ghG+C+ +   C C++gy G+ C
  EFC38200.1 446 SRVCNGHGICEGPD-ICNCSTGYIGPLC 472
                 568********777.9***********9 PP

  == domain 4  score: 17.0 bits;  conditional E-value: 2.8e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +C+ghG+C+ ++  C C++gy G  C
  EFC38200.1 485 SRACNGHGICEGPN-ICNCSTGYIGSFC 511
                 568********888.9***********9 PP

  == domain 5  score: 13.3 bits;  conditional E-value: 4.1e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +C+ hG+C+ ++  C C +gy G  C
  EFC38200.1 526 ACNRHGICEGPN-ICNCTTGYVGSFC 550
                 6********888.9***********9 PP

  == domain 6  score: 15.0 bits;  conditional E-value: 1.2e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ghG+C+ +  +C C +gy G  C
  EFC38200.1 565 VCNGHGICEGPD-VCNCTTGYVGSFC 589
                 6********888.9***********9 PP

  == domain 7  score: 13.0 bits;  conditional E-value: 5.1e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +C+ hG+C+ ++  C C +gy G  C
  EFC38200.1 602 SRACNRHGICEGPN-ICNCTTGYVGSFC 628
                 568********888.9***********9 PP

  == domain 8  score: 13.4 bits;  conditional E-value: 3.8e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ hG+C+ ++  C C +gy G  C
  EFC38200.1 643 VCNRHGICEGPN-ICNCTTGYVGSFC 667
                 6********888.9***********9 PP

  == domain 9  score: 15.1 bits;  conditional E-value: 1.1e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +C+ghG+C+ +  +C C +gy G  C
  EFC38200.1 682 ACNGHGICEGPD-VCNCTTGYVGSFC 706
                 6********888.9***********9 PP

  == domain 10  score: 5.4 bits;  conditional E-value: 0.012
       EGF_2   7 iCgghGtCv 15 
                  C+ghG+C+
  EFC38200.1 721 VCNGHGICE 729
                 6*******8 PP

  == domain 11  score: 1.6 bits;  conditional E-value: 0.18
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +iC ++G+ ++q  +C C +gy  k+C
  EFC38200.1 1105 SICLNGGVYNSQLRKCICVNGYKKKDC 1131
                  578888888777757*******99999 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   7.5e-05      0.15       3      26 ..      44      67 ..      42      69 .. 0.90
   2 ?    3.5   0.0     0.043        85      14      26 ..     111     123 ..     104     125 .. 0.87
   3 !   24.3   0.0   1.1e-08   2.1e-05       1      27 [.     154     181 ..     154     182 .. 0.96
   4 !    9.4   0.0   0.00058       1.1       6      27 ..     216     237 ..     216     238 .. 0.94
   5 !   17.4   0.0   1.6e-06    0.0032       3      27 ..     268     296 ..     266     297 .. 0.84
   6 ?    4.2   0.0     0.024        49       9      24 ..     334     350 ..     326     352 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 7.5e-05
                SEEEEEEETTTEEEEEECCCTEEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrvq 26
                +P G+  + nGdiyVa++  hr+ 
  EFC38200.1 44 SPKGTYFSANGDIYVAETQGHRIS 67
                7999******************96 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.043
                 EEEEEECCCTEEE CS
         NHL  14 diyVaDsenhrvq 26 
                 +++V+Ds+nh ++
  EFC38200.1 111 QLIVSDSGNHVIR 123
                 699*******665 PP

  == domain 3  score: 24.3 bits;  conditional E-value: 1.1e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P+G++vd ++G++++aD+ n+r+++
  EFC38200.1 154 LNNPSGIVVDsKTGELFIADTANNRIRK 181
                 79************************97 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.00058
                 EEEEETTTEEEEEECCCTEEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvqv 27 
                 G+a+d n ++y+aD +n r+++
  EFC38200.1 216 GIALDVNSELYIADANNYRIRK 237
                 89******************87 PP

  == domain 5  score: 17.4 bits;  conditional E-value: 1.6e-06
                 SEEEEEEETTTEEEEEE....CCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaD....senhrvqv 27 
                 + +G+avd+nG++y+++    + nhr+++
  EFC38200.1 268 FVNGIAVDTNGEVYITEsengFSNHRIRK 296
                 668**************888888888875 PP

  == domain 6  score: 4.2 bits;  conditional E-value: 0.024
                 EE.TTTEEEEEECCCTE CS
         NHL   9 vd.snGdiyVaDsenhr 24 
                 v  ++G+++++D++n+ 
  EFC38200.1 334 VRqTTGEVLISDTGNNF 350
                 55578*********985 PP

>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.4  10.7   1.3e-22   2.5e-19     117     435 ..     770    1072 ..     759    1085 .. 0.76

  Alignments for each domain:
  == domain 1  score: 69.4 bits;  conditional E-value: 1.3e-22
         REJ  117 sqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanl.tynftltvskrsrksasteqtilv...vdgepplvsiec 209 
                  + +  ++++ c++++   + n  +++ ni ++ +s      ++++l+++a+++ +   ty +tl++ k+ r s s+   +      +  pp+v +  
  EFC38200.1  770 N-EAETWSYVCQDEN---FTNCGQTIANILSNYAS-----IKSKTLELSADNFPSIDsTYSITLNIVKGVR-SFSSLISLKFpkeNQKLPPIVNLLN 856 
                  2.2333444574444...55666666666655555.....778899999999987555************9.77777777662225567999*9999 PP

         REJ  210 isncngkvnpndrlvllasclncakd.lkdvtfeWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasis 305 
                  +   +  +++++ l+l++s +n +   +k++  eW+l  +s   +  ++k++  l+++++   +v++  +L++g+s  lt +vtd +++ s++ s+s
  EFC38200.1  857 VIPNRNRLSKSEFLNLQISVTNSDGLdVKNLKREWKLNGQSID-DNYLTKMSTALSDSNN---IVLSITYLDEGSSNVLTCQVTDLDSQLSSTFSYS 949 
                  9999999************55555555********55555544.4455556666776666...********************************** PP

         REJ  306 fkvnepPtgGtcsvtPlegvaletaftvrCqgwtDkdqPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarv. 401 
                  f++   P  + csv P++g+alet+ft++C++ ++kd+ L +++s+  ++      l+ eg n     ++LP + +   + +++ +++ D    ++ 
  EFC38200.1  950 FSIITSPKPCPCSVSPSTGYALETEFTFSCTNCQNKDNTLAFSLSFVDDKSGALIPLVIEGGNT--FTTKLPYPIS---NPLMFDITIVDIETLASv 1041
                  ********************************************66656666666777888877..8899999888...579999999999887776 PP

         REJ  402 svsltitVkppavnns..tieellenrtrnenelsk 435 
                  +   +i+   p++++   +      ++  + n +++
  EFC38200.1 1042 QNYQNIQMILPKASSVreVK-----TKVAKWNTFQT 1072
                  99999999999998883322.....22223333333 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   2.0   4.5e-05     0.089       3      31 ..     366     392 ..     365     393 .. 0.82
   2 !    8.4   6.6    0.0014       2.7       3      31 ..     405     431 ..     403     432 .. 0.88
   3 !   11.0   4.1    0.0002      0.41       6      31 ..     449     470 ..     443     471 .. 0.86
   4 !    7.4   5.8    0.0028       5.5       5      31 ..     486     509 ..     481     510 .. 0.85
   5 !    6.3   4.6    0.0063        12       4      31 ..     523     548 ..     521     549 .. 0.87
   6 !   10.5   5.2   0.00029      0.58       3      31 ..     561     587 ..     559     588 .. 0.88
   7 ?    4.7   4.7     0.019        38       6      31 ..     605     626 ..     598     627 .. 0.84
   8 !    6.7   5.1    0.0045         9       3      31 ..     639     665 ..     637     666 .. 0.87
   9 !   10.1   5.6    0.0004      0.79       3      31 ..     678     704 ..     676     705 .. 0.88
  10 ?    3.1   0.4     0.061   1.2e+02       3      15 ..     717     730 ..     715     738 .. 0.81
  11 ?    5.5   0.3     0.011        21       6      29 ..    1107    1127 ..    1101    1130 .. 0.79
  12 ?    0.9   1.4      0.29   5.8e+02       8      25 ..    1413    1429 ..    1412    1431 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 4.5e-05
                 STT..STTT-EE.EEETTTEEEEEECTTEEST CS
         EGF   3 pnp..CsngGtC.vdtgrggytCiCpeGytGk 31 
                 ++p  Cs++G+C +     +  C+C +Gy G+
  EFC38200.1 366 SDPmvCSGHGICyL-----TDVCTCNPGYIGS 392
                 57888*******44.....446********96 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0014
                 STT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++p  C+++G+C     g  +C C++Gy G+
  EFC38200.1 405 SDPraCNGHGIC----EGPNICNCTTGYVGS 431
                 58999*******....58899*******996 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.0002
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+++G+C     g  +C C++Gy G+
  EFC38200.1 449 CNGHGIC----EGPDICNCSTGYIGP 470
                 *******....6899*********96 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.0028
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + C+++G+C     g  +C C++Gy G+
  EFC38200.1 486 RaCNGHGIC----EGPNICNCSTGYIGS 509
                 34*******....58899********97 PP

  == domain 5  score: 6.3 bits;  conditional E-value: 0.0063
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +p  C+ +G+C     g  +C C++Gy G+
  EFC38200.1 523 DPraCNRHGIC----EGPNICNCTTGYVGS 548
                 6778*******....58899*******996 PP

  == domain 6  score: 10.5 bits;  conditional E-value: 0.00029
                 STT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++p  C+++G+C     g   C C++Gy G+
  EFC38200.1 561 SDPrvCNGHGIC----EGPDVCNCTTGYVGS 587
                 58999*******....6889********996 PP

  == domain 7  score: 4.7 bits;  conditional E-value: 0.019
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+ +G+C     g  +C C++Gy G+
  EFC38200.1 605 CNRHGIC----EGPNICNCTTGYVGS 626
                 999****....57889*******996 PP

  == domain 8  score: 6.7 bits;  conditional E-value: 0.0045
                 STT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++p  C+ +G+C     g  +C C++Gy G+
  EFC38200.1 639 SDPrvCNRHGIC----EGPNICNCTTGYVGS 665
                 58899*******....58899*******996 PP

  == domain 9  score: 10.1 bits;  conditional E-value: 0.0004
                 STT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++p  C+++G+C     g   C C++Gy G+
  EFC38200.1 678 SDPraCNGHGIC----EGPDVCNCTTGYVGS 704
                 58999*******....6889********996 PP

  == domain 10  score: 3.1 bits;  conditional E-value: 0.061
                 STT..STTT-EEEEE CS
         EGF   3 pnp..CsngGtCvdt 15 
                 ++p  C+++G+C ++
  EFC38200.1 717 SDPrvCNGHGIC-EG 730
                 58999*******.44 PP

  == domain 11  score: 5.5 bits;  conditional E-value: 0.011
                  STTT-EEEEETTTEEEEEECTTEE CS
         EGF    6 CsngGtCvdtgrggytCiCpeGyt 29  
                  C+ngG  v+++ +  +CiC +Gy+
  EFC38200.1 1107 CLNGG--VYNS-QLRKCICVNGYK 1127
                  66666..6666.999********7 PP

  == domain 12  score: 0.9 bits;  conditional E-value: 0.29
                  TT-EE..EEETTTEEEEEEC CS
         EGF    8 ngGtC..vdtgrggytCiCp 25  
                  n+  C  v ++ ++ +C+Cp
  EFC38200.1 1413 NN--CkiVVNQ-ETIICQCP 1429
                  77..8878888.9******9 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.0    0.0041       8.2     186     217 ..      45      76 ..      25      82 .. 0.83
   2 !    6.6   0.0    0.0025         5     183     218 ..     153     190 ..      91     197 .. 0.79
   3 ?    3.9   0.0     0.018        35     188     218 ..     159     190 ..     157     251 .. 0.70
   4 ?    2.0   0.0     0.063   1.3e+02     186     217 ..     269     304 ..     250     311 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0041
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGkli 217
                 p G    a+G ++vA  +g++++r++++G ++
  EFC38200.1  45 PKGTYFSANGDIYVAETQGHRISRISKNGMID 76 
                 67888999********************9654 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0025
         SGL 183 e.gepDGlavDa.eGnvwvAvwgggkvvrfdpdGklie 218
                 + ++p G++vD+ +G++++A  ++++++++ ++G++i+
  EFC38200.1 153 KlNNPSGIVVDSkTGELFIADTANNRIRKILTNGTIIT 190
                 244699******9*********************9987 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.018
         SGL 188 GlavDa.eGnvwvAvwgggkvvrfdpdGklie 218
                 G++vD+ +G++++A  ++++++++ ++G++i+
  EFC38200.1 159 GIVVDSkTGELFIADTANNRIRKILTNGTIIT 190
                 67777777777777777777777777777665 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.063
         SGL 186 pDGlavDaeGnvwvAvw....gggkvvrfdpdGkli 217
                 + G+avD +G+v+++      ++++++++ ++G++i
  EFC38200.1 269 VNGIAVDTNGEVYITESengfSNHRIRKILTNGTII 304
                 458888888888888763333555888888777766 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   2.8   3.3e-05     0.066       3      39 ..    1466    1503 ..    1464    1513 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 3.3e-05
     DUF4834    3 fLlfi.lifiiailviglsilsvilrtvfglgsrkkss 39  
                  fLlf+ l++i+++++ig++i+  + r+  g ++++ ++
  EFC38200.1 1466 FLLFLvLFIILIVIIIGIVIVCLVKRRRNGGSKKSAAH 1503
                  89999888888899999999999*99997755444444 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0         4     8e+03      55      82 ..      44      70 ..      39      72 .. 0.69
   2 ?   10.1   0.0   0.00035      0.69      41      78 ..     142     179 ..     127     183 .. 0.89
   3 ?    0.5   0.0      0.36   7.1e+02      46      73 ..     259     285 ..     246     292 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 4
  Arylesterase 55 sanGInidadkkyiyvadilresihvmk 82
                  s+ G  ++a+   iyva+   + i ++ 
    EFC38200.1 44 SPKGTYFSANG-DIYVAETQGHRISRIS 70
                  66665555544.5899999999887765 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00035
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   y+++ +   +++l+ + GI++d++   +++ad  ++ i
    EFC38200.1 142 YNGDGIDAKIAKLNNPSGIVVDSKTGELFIADTANNRI 179
                   7788889999**********************999987 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.36
  Arylesterase  46 vkvvasglssanGInidadkkyiyvadi 73 
                   v    ++l + nGI +d++   +y++++
    EFC38200.1 259 VLATNAKLAFVNGIAVDTNGE-VYITES 285
                   555667899********9875.798875 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.5     5e-05       0.1      44     108 ..    1447    1511 ..    1409    1513 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5e-05
     TMEM154   44 lssaelsnesdqlel.vlmiiiPlvllillllvviiliqkkkrkrsKddekseaesdeldsenvkv 108 
                   s  ++++ sd+ +l  l+ ++ lvl+i+l++++i ++ ++  kr+++   s+ +   ++ e+vk+
  EFC38200.1 1447 VSVEQVAQPSDSSNLlYLLFLLFLVLFIILIVIIIGIVIVCLVKRRRNG-GSKKSAAHVEMETVKT 1511
                  4555666667777763466777777777776655533334444444444.4555555667777765 PP

>> DAG1  Dystroglycan (Dystrophin-associated glycoprotein 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.99     2e+03      96     156 ..    1029    1089 ..    1026    1104 .. 0.81
   2 ?    9.1   1.3   0.00039      0.77      56     176 ..    1372    1495 ..    1317    1503 .. 0.57

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.99
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        DAG1   96 kltnisvvgssscrhlefiplnqleeiPsevasteapeedaeksseddvylhtvipavvva 156 
                   +t + + + +s +++++i++  ++    +   t++++ ++ + s +++ l  +i++  ++
  EFC38200.1 1029 DITIVDIETLASVQNYQNIQMILPKASSVREVKTKVAKWNTFQTSLQQNDLRRMIFSSAII 1089
                  5677788899999*******99888888888899999999999999998888888776665 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00039
                  XXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXX CS
        DAG1   56 nntlklepcpkeqvaglskkildedgs.lreafkralePelkltnisvvgssscrhlefiplnqleeiPsevasteapeedae.ksseddvylhtvi 150 
                  n+++  +  +++q    s++  +       ++ +   e e +  +i v++ ++  +  + + +q   + ++++  +++e+ a+   s +  yl  ++
  EFC38200.1 1372 NQSISFSFPRNDQFSARSEQSFEYSCIvIWNITQVRPENENNNCKIVVNQETIICQCPYQNQTQVGVLRTAISRRVSVEQVAQpSDSSNLLYLLFLL 1468
                  4555555555566555555544443330333333334445555666776666655666666667777777777777776655514566778988887 PP

                  XXXX.XXXXXXXXXXXXXXXXXXXXXX CS
        DAG1  151 pavv.vaailliagiiamicyrkkrkG 176 
                  + v+ ++ i++i gi++++  +++r+G
  EFC38200.1 1469 FLVLfIILIVIIIGIVIVCLVKRRRNG 1495
                  776525666777777777777788887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1173  (0.0654247); expected 358.6 (0.02)
Passed bias filter:                      564  (0.0314574); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 1.09u 0.36s 00:00:01.45 Elapsed: 00:00:00.55
# Mc/sec: 8297.31
//
Query:       EFC38201.1  [L=181]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.84   10.7   7.2       0.14   13.1   1.9    2.0  2  DUF3774   Wound-induced protein


Domain annotation for each model (and alignments):
>> DUF3774  Wound-induced protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.3      0.11   1.9e+03      32      55 ..       9      31 ..       2      49 .. 0.40
   2 ?   13.1   1.9   8.1e-06      0.14       4      62 ..      96     162 ..      92     165 .. 0.55

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.11
     DUF3774 32 snl..aslsqakkaldsssssskeek 55
                +++  +  s+ +k+++  ++  ++++
  EFC38201.1  9 NMSfiDETSNVTKKAK-VKK--RNKE 31
                3333311222222111.111..2222 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 8.1e-06
     DUF3774   4 svgaVealkDq...G.lcRwnyaLrslhqaaksnlaslsqakkald.....ssssss..keekrkqaEes 62 
                 s g+ e +kD       c+  ++   l+q+a+sn++ +s++ + ++     sss  s  +++ +k++Ee+
  EFC38201.1  96 SSGTSENVKDTiitKvKCKTMNNTNNLNQHASSNIEYSSSSLT-INnssggSSS--SgsSDNTSKEEEEE 162
                 55899999999543123555566788999****9944333333.2234444222..13344555544443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1823  (0.101679); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1063.11
//
Query:       EFC38202.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1864  (0.103966); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 1101.39
//
Query:       EFC38203.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       563  (0.0314016); expected 358.6 (0.02)
Passed bias filter:                      259  (0.0144459); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1192.32
//
Query:       EFC38204.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1199  (0.0668749); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1131.90
//
Query:       EFC38205.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00094   19.1   0.0      0.002   18.1   0.0    1.5  1  RWP-RK        RWP-RK domain
  ------ inclusion threshold ------
      0.042   13.7   0.0      0.073   12.9   0.0    1.3  1  HTH_30        PucR C-terminal helix-turn-helix domain
       0.15   11.7   0.0       0.23   11.2   0.0    1.3  1  Sigma70_r4_2  Sigma-70, region 4


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   3.3e-07     0.002       2      43 ..      96     141 ..      95     144 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 3.3e-07
      RWP-RK   2 ltleelqqyFslplkeAAksLgvskttLKricR....elgIsRWPy 43 
                 ++ ee++++ +l+  +AAk L++  +tLKr+       lg+  WP+
  EFC38205.1  96 ISNEEMIRVLHLSQIQAAKILDCHLSTLKRRFNktkhSLGLDAWPQ 141
                 677999************************9776666899999996 PP

>> HTH_30  PucR C-terminal helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   1.2e-05     0.073      15      43 ..     109     137 ..     105     142 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.2e-05
                 HHHHHHHHTS-HHHHHHHHHHHHHHHS-- CS
      HTH_30  15 isatAkaLhvHrnTlryRLrrieellgld 43 
                   ++Ak L +H  Tl+ R ++ +  lgld
  EFC38205.1 109 QIQAAKILDCHLSTLKRRFNKTKHSLGLD 137
                 5689***********************99 PP

>> Sigma70_r4_2  Sigma-70, region 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   3.8e-05      0.23      20      49 ..     100     129 ..     100     134 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 3.8e-05
                   HHHHTS---HHHHHHHHT--HHHHHHHHHH CS
  Sigma70_r4_2  20 llryleglsykEIAellgisegtVksrlsR 49 
                   +++++ +ls+ ++A++l+++ +t k+r  +
    EFC38205.1 100 EMIRVLHLSQIQAAKILDCHLSTLKRRFNK 129
                   69***********************99765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       779  (0.0434492); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 1121.24
//
Query:       EFC38206.1  [L=944]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-11   43.1   0.9    9.2e-11   41.6   0.9    1.7  1  Pkinase   Protein kinase domain
    0.00024   20.5   0.2    0.00055   19.3   0.2    1.5  1  Kdo       Lipopolysaccharide kinase (Kdo/WaaP) family
    0.00062   19.8   0.1     0.0012   18.8   0.1    1.3  1  APH       Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.6   0.9   1.5e-14   9.2e-11      95     258 ..     726     921 ..     677     925 .. 0.79

  Alignments for each domain:
  == domain 1  score: 41.6 bits;  conditional E-value: 1.5e-14
                 --HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH....TTSCBSHHHHHHHHHHHHHH CS
     Pkinase  95 lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl....keneyskkvDvWslGvilye 189
                  +++++  ++++++ +le +H+++ +H D+Kp+ iL++ ++ + ++DF ++ + e         +t+ + +PE      ++ + s+++ ++s+++  + 
  EFC38206.1 726 KDKTDLLTWLQSTALALEPIHKANRVHGDIKPQHILMK-DDRICLIDFEFSVNKEDPI----NGCTKGFHPPEYDdfpnTRPPASTSAEIYSVALSGLY 819
                 34557889999***************************.999*********9988876....789*********9988666778*********887666 PP

                 HHHS...S-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS.............................-HHHHHHHHHHT-SSGCCSTT.H CS
     Pkinase 190 lltg...kppfsgekgkekvekeldqlekilkilgetkeklpeasei.............................seeakdllkkllkkdpkkRlt.a 255
                 ll+    +   +++++++++e++ +q+e+ +  ++ ++ +++++ e+                             ++ +k+ll+k+lk +pk+R+  a
  EFC38206.1 820 LLYSswrEDYEKADNSDSTIEEKKEQVESDRVDMESKDAEIDKNAEMddsentatslkidinvkrnnlaklvdyleDQVVKSLLEKMLKTNPKERIKdA 918
                 665411145555556666666666665555555666666666666668889999*********************999*****************9756 PP

                 HHH CS
     Pkinase 256 eel 258
                 +el
  EFC38206.1 919 TEL 921
                 655 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.2   9.2e-08   0.00055     122     170 ..     733     776 ..     707     782 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 9.2e-08
         Kdo 122 allkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldkar 170
                 + l+ ++ + + +h+a++ H+d+ +++il++ +      i+liD++ + 
  EFC38206.1 733 TWLQSTALALEPIHKANRVHGDIKPQHILMKDDR-----ICLIDFEFSV 776
                 4578899999*********************996.....******9665 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1     2e-07    0.0012     165     197 ..     747     776 ..     720     778 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 2e-07
                 -EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 165 ptvllHgDlhpgNllvdpddgrvtGviDfedag 197
                 ++  +HgD++p+++l++  d+r+ ++iDfe+++
  EFC38206.1 747 KANRVHGDIKPQHILMK--DDRI-CLIDFEFSV 776
                 56689************..9**9.******975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (944 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1611  (0.0898544); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.83u 0.33s 00:00:01.15 Elapsed: 00:00:00.51
# Mc/sec: 5611.24
//
Query:       EFC38207.1  [L=1082]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.2e-14   52.9   4.1    7.5e-10   39.3   0.7    3.1  2  Ank_2         Ankyrin repeats (3 copies)
    1.3e-12   47.6   0.5    4.8e-09   36.3   0.2    3.6  3  Ank_5         Ankyrin repeats (many copies)
    6.1e-11   42.9   0.0    1.7e-10   41.4   0.0    1.7  1  VWA           von Willebrand factor type A domain
    1.8e-10   40.1   2.4    0.00052   20.3   0.1    5.6  5  Ank_3         Ankyrin repeat
      2e-10   41.0   2.0    1.4e-06   28.7   0.2    4.1  4  Ank_4         Ankyrin repeats (many copies)
    9.3e-08   32.2   4.0    2.1e-05   24.7   0.4    3.6  3  Ank           Ankyrin repeat
    4.7e-06   27.2   0.0    1.3e-05   25.8   0.0    1.8  1  VWA_2         von Willebrand factor type A domain
     0.0004   20.1   1.8     0.0004   20.1   1.8    2.3  2  zf-Nse        Zinc-finger of the MIZ type in Nse subunit
    0.00055   20.1   0.1     0.0031   17.6   0.0    2.2  2  U-box         U-box domain
     0.0064   16.5   0.6      0.019   15.0   0.6    1.9  1  zf-RING_UBOX  RING-type zinc-finger
     0.0074   16.2   0.0      0.019   14.9   0.0    1.7  1  VWA_3         von Willebrand factor type A domain
  ------ inclusion threshold ------
      0.015   14.7   0.0      0.027   13.9   0.0    1.3  1  VWA_CoxE      VWA domain containing CoxE-like protein
        2.2    8.5   6.1        5.4    7.3   6.1    1.7  1  zf-C3HC4_4    zinc finger of C3HC4-type, RING
        2.7    8.4   6.7        1.2    9.5   3.5    2.2  2  zf-RING_2     Ring finger domain


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.3   0.7   5.8e-13   7.5e-10      12      80 ..     572     643 ..     552     646 .. 0.81
   2 !   13.2   0.1   8.1e-05       0.1       2      83 .]     703     817 ..     702     817 .. 0.76

  Alignments for each domain:
  == domain 1  score: 39.3 bits;  conditional E-value: 5.8e-13
       Ank_2  12 lvklLlegadpnkngktaLhyAakngnleivklLleh......adndgrtpLhyAarsghleivklLlekgadin 80 
                 +++lL  ++d   +g+taLh+A+++gnl +vklL++       ++++g ++L +A+ +g  ++v +Ll++ga+i 
  EFC38207.1 572 CLNLLD-STDR--DGNTALHLACMKGNLVAVKLLVKLgasltiINSSGLSALDLAILFGFDRTVTFLLDNGAKIA 643
                 444444.4553..69***********9999*****945567788899************************9986 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 8.1e-05
       Ank_2   2 hlAakngnlelvklLl.egadpnkngktaLhyAakngnleivklLle....h..............adnd....................grtpLhyAa 61 
                  lA+k++nlel++  + +g++p    +  L++A  +g+l i k+L +    +                 +                    g  +L+ A+
  EFC38207.1 703 DLAIKKNNLELFEKCIkSGFKPF---EYHLYLAMDYGSLPIFKALAKtidvNkygllenkfievlkN--NshlagyldpreitnvrglvaG-CALIEAV 795
                 578898989*******9999998...899*****************955441445544455444430..1455566666666777777745.6****** PP

       Ank_2  62 rsghleivklLlekgadinlkd 83 
                  +g+l+++k ++e gad  ++d
  EFC38207.1 796 VYGNLNAAKAFIELGADASIQD 817
                 ************99***99886 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.3   0.2   3.7e-12   4.8e-09       7      56 .]     574     623 ..     568     623 .. 0.94
   2 ?    3.4   0.0     0.077        98      17      36 ..     699     718 ..     693     727 .. 0.86
   3 ?    3.5   0.0     0.074        94      23      49 ..     794     820 ..     790     824 .. 0.87

  Alignments for each domain:
  == domain 1  score: 36.3 bits;  conditional E-value: 3.7e-12
       Ank_5   7 advnrldgggntpLhvAakygaadvvrlLlargadlnltdsrGltaldlA 56 
                 + ++ +d++gnt+Lh+A+ +g++  v+lL++ ga+l++ +s+Gl+aldlA
  EFC38207.1 574 NLLDSTDRDGNTALHLACMKGNLVAVKLLVKLGASLTIINSSGLSALDLA 623
                 67899********************************************9 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.077
       Ank_5  17 ntpLhvAakygaadvvrlLl 36 
                 ++ L +A+k+++++++++++
  EFC38207.1 699 EEMLDLAIKKNNLELFEKCI 718
                 57899**********99987 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.074
       Ank_5  23 AakygaadvvrlLlargadlnltdsrG 49 
                 A+ yg+++ ++ +++ gad+ ++d +G
  EFC38207.1 794 AVVYGNLNAAKAFIELGADASIQDQCG 820
                 6779*******************9888 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.4   0.0   1.3e-13   1.7e-10       5     162 ..     134     296 ..     132     315 .. 0.81

  Alignments for each domain:
  == domain 1  score: 41.4 bits;  conditional E-value: 1.3e-13
                 EEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHGTSST.. CS
         VWA   5 vlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssagaRe.. 101
                 + D+Sgsm+++ +e+v + +k+++++   +++ +   +v + s++k++ +++   + +++++++++  + gggt+  ++a + a + + ++s   Re  
  EFC38207.1 134 LADVSGSMQGRPWEQVCTSLKHFAQQSF-NNPAIICRMVAYESSAKEI-DMKG--TLQSIIRNIET-AFTGGGTD-FASAFQLACTIITRESGQDREnl 226
                 67***********************999.7888999*******99988.3333..55899999999.68888888.**********6666666699977 PP

                 .TSEEEEEEEESS--CSS........HTHHHHHHHHGCTEEEEEEEESSSHHHHHHHHHSSSSC.HHCEEE CS
         VWA 102 .nakkviilltdGksndg........dpkeaaneakeqgikvfavGvgnadekelLnkiasepg.eghvft 162
                    + vi +ltdG++ ++         ++e++n++ + +i++++vG+g++++ elL +i + ++ eg +++
  EFC38207.1 227 pFGNVVITFLTDGEDFSKvgkpgglqYLSEEINRVYRGDITIHTVGFGSHHNLELLDNIRKVGTiEG-AYR 296
                 6677888899**88844345888888******************************99966666422.222 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.1     4e-07   0.00052       1      29 [.     582     609 ..     582     611 .. 0.92
   2 ?    6.2   0.0     0.016        20       2      29 ..     616     642 ..     615     644 .. 0.92
   3 ?    0.2   0.0       1.3   1.7e+03       5      26 ..     701     721 ..     699     724 .. 0.84
   4 ?    1.5   0.0      0.51   6.6e+02       6      30 ..     729     751 ..     728     752 .. 0.89
   5 ?    5.6   0.1     0.023        30       5      30 ..     790     814 ..     789     815 .. 0.91

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 4e-07
       Ank_3   1 nGetpLhlAarsgnleivkfLlenkgadv 29 
                 +G+t+LhlA++ gnl  vk+L++  ga +
  EFC38207.1 582 DGNTALHLACMKGNLVAVKLLVK-LGASL 609
                 69*************99******.99976 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.016
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                 G ++L lA+++g    v fLl+ +ga +
  EFC38207.1 616 GLSALDLAILFGFDRTVTFLLD-NGAKI 642
                 899***********99******.89987 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 1.3
       Ank_3   5 pLhlAarsgnleivkfLlenkg 26 
                 +L lA++ +nle+ + +++  g
  EFC38207.1 701 MLDLAIKKNNLELFEKCIK-SG 721
                 6899********9999998.44 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.51
       Ank_3   6 LhlAarsgnleivkfLlenkgadvn 30 
                 L+lA+ +g+l+i k+L +   +dvn
  EFC38207.1 729 LYLAMDYGSLPIFKALAK--TIDVN 751
                 789********9999999..78888 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.023
       Ank_3   5 pLhlAarsgnleivkfLlenkgadvn 30 
                 +L +A+ +gnl+ +k+++e  gad  
  EFC38207.1 790 ALIEAVVYGNLNAAKAFIE-LGADAS 814
                 7899***************.9**976 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.1   2.5e-07   0.00032      28      55 .]     577     603 ..     564     603 .. 0.85
   2 !   28.7   0.2   1.1e-09   1.4e-06       2      55 .]     584     636 ..     583     636 .. 0.93
   3 ?   -2.6   0.0       7.5   9.6e+03       5      17 ..     702     714 ..     697     723 .. 0.57
   4 ?    4.5   0.0     0.045        57       5      36 ..     791     821 ..     789     825 .. 0.88

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 2.5e-07
       Ank_4  28 naqdnrsGetalhiAakrgnveilklLl 55 
                 + + +r+G+talh A+++gn+ ++klL+
  EFC38207.1 577 DST-DRDGNTALHLACMKGNLVAVKLLV 603
                 455.9****************9999996 PP

  == domain 2  score: 28.7 bits;  conditional E-value: 1.1e-09
       Ank_4   2 ltaLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklLl 55 
                 +taLh a+++g+l +v+lL+  ga++    n+sG++al+ A+++g+ + + +Ll
  EFC38207.1 584 NTALHLACMKGNLVAVKLLVKLGASLTII-NSSGLSALDLAILFGFDRTVTFLL 636
                 89************************998.***************988888876 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 7.5
       Ank_4   5 Lhyaaisgrlelv 17 
                 L+ a+++++lel 
  EFC38207.1 702 LDLAIKKNNLELF 714
                 3444445555444 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.045
       Ank_4   5 LhyaaisgrlelvrlLlekgadinaqdnrsGe 36 
                 L  a+ +g+l +++  +e gad   q + +G+
  EFC38207.1 791 LIEAVVYGNLNAAKAFIELGADASIQ-DQCGM 821
                 667889****************9999.88887 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.7   0.4   1.6e-08   2.1e-05       1      31 [.     582     613 ..     582     614 .. 0.90
   2 ?    6.2   0.1     0.012        15       2      32 .]     616     647 ..     615     647 .. 0.90
   3 ?   -0.3   0.0       1.4   1.8e+03       9      31 ..     794     817 ..     773     818 .. 0.84

  Alignments for each domain:
  == domain 1  score: 24.7 bits;  conditional E-value: 1.6e-08
                 TSBBHHHHHHHHTTHHHHHHHHT.TTSTTCBT CS
         Ank   1 dGnTPLHlAatngkkriiklLLh.GAnlnald 31 
                 dGnT+LHlA++ g++  +klL++ GA+l++ +
  EFC38207.1 582 DGNTALHLACMKGNLVAVKLLVKlGASLTIIN 613
                 9******************99955***99866 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.012
                 SBBHHHHHHHHTTHHHHHHHH.TTTSTTCBTT CS
         Ank   2 GnTPLHlAatngkkriiklLL.hGAnlnaldn 32 
                 G ++L lA+ +g  r + +LL +GA ++++++
  EFC38207.1 616 GLSALDLAILFGFDRTVTFLLdNGAKIASHND 647
                 889******999999******88***999985 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 1.4
                 HHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   9 AatngkkriiklLL.hGAnlnald 31 
                 A+ +g+++ +k+++  GA+  ++d
  EFC38207.1 794 AVVYGNLNAAKAFIeLGADASIQD 817
                 667899999999*95599977776 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.0     1e-08   1.3e-05       3     107 .]     133     240 ..     131     240 .. 0.78

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 1e-08
       VWA_2   3 fvlDtSgSmrngdygptrleaakdaveallksl...pgdrvglvtfsdgpevlipltkdkakilnalrnleak..gggtnlaaaLqlarkalkkrr... 93 
                  + D+SgSm+++      +e++   ++++ ++    p   +  v+++++++ +i+++    ++++++rn+e+   gggt++a+a+qla  ++ +++   
  EFC38207.1 133 ALADVSGSMQGR-----PWEQVCTSLKHFAQQSfnnPAIICRMVAYESSAK-EIDMKG---TLQSIIRNIETAftGGGTDFASAFQLACTIITRESgqd 222
                 589********9.....8*************65443566778888887765.778777...555555666655558***************97777667 PP

       VWA_2  94 ....kgekrvivlitDge 107
                        + vi ++tDge
  EFC38207.1 223 renlPFGNVVITFLTDGE 240
                 778888889999999986 PP

>> zf-Nse  Zinc-finger of the MIZ type in Nse subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   1.8   3.2e-07    0.0004       6      56 ..       3      51 ..       1      52 [. 0.94
   2 ?   -2.1   0.0       2.7   3.5e+03      11      26 ..     882     897 ..     878     898 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 3.2e-07
                XSSBXXSB-TTTSSB-SSEEEESSS--EEEHHHHHHHCTTTS-EE-SCCC- CS
      zf-Nse  6 eeerislkCPltlqpfeePvtskkCpHvFEreaIlelikrkktvkCPvagC 56
                +ee  +l CP++++ +e+P+    C   F r+++ +++++ +   CP   C
  EFC38207.1  3 TEEHDDLLCPISRELLEDPIVVPCCGRAFSRQSLANYFSTIEYRTCPC--C 51
                56788999***************************************9..7 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2.7
                 XSB-TTTSSB-SSEEE CS
      zf-Nse  11 slkCPltlqpfeePvt 26 
                 +l  P+t++ + eP++
  EFC38207.1 882 DLDEPVTQELIIEPMK 897
                 6777999999999985 PP

>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   2.4e-06    0.0031       3      53 ..       7      59 ..       6      80 .. 0.86
   2 ?   -1.4   0.0       2.2   2.8e+03       7      21 ..     885     899 ..     882     901 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 2.4e-06
                GGGB-TTT-SB-SSEEEETTT.EEEEHHHHHHHHTT..SSB-TTT-SB--GGG CS
       U-box  3 defldpitlelmkdPvilpsg.vvvdrstiekhlls.rdktdPftrepltqdq 53
                d +l+pi++el+ dP+++p     + r++++++    + +t+P  r  l++ +
  EFC38207.1  7 DDLLCPISRELLEDPIVVPCCgRAFSRQSLANYFSTiEYRTCPCCRGNLDEFD 59
                779****************877**********999877899999998887655 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.2
                 -TTT-SB-SSEEEET CS
       U-box   7 dpitlelmkdPvilp 21 
                  p+t el+++P+ l+
  EFC38207.1 885 EPVTQELIIEPMKLA 899
                 599*********987 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.6   1.5e-05     0.019       1      39 []      11      49 ..      11      49 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.5e-05
  zf-RING_UBOX  1 CpIClelftdPlvlp.CGHtFCreClwelskslegafkCP 39
                  CpI++el++dP+v+p CG  F r+ l  + +s   +++CP
    EFC38207.1 11 CPISRELLEDPIVVPcCGRAFSRQSL-ANYFSTIEYRTCP 49
                  ***********55544**********.7899999999998 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   1.5e-05     0.019      59     146 ..     184     286 ..     131     295 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.5e-05
       VWA_3  59 aelqealqkikelelslgasnlegaLkealr...qp....akpgevrsvil..ltDgssaqge......ervsdlisr.arekirfhalglgsslsaam 141
                  +lq +   i++ +   g+++ ++a + a +    +    + +  + +v++  ltDg + ++       +++s++i r  r++i++h++g+gs ++ ++
  EFC38207.1 184 GTLQSIIRNIETAFT-GGGTDFASAFQLACTiitREsgqdRENLPFGNVVItfLTDGEDFSKVgkpgglQYLSEEINRvYRGDITIHTVGFGSHHNLEL 281
                 689999999999888.9********99777433222444455555566665559****85533456777********9566***************999 PP

       VWA_3 142 lqaLA 146
                 l+++ 
  EFC38207.1 282 LDNIR 286
                 99875 PP

>> VWA_CoxE  VWA domain containing CoxE-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   2.1e-05     0.027      56     147 ..     127     219 ..     115     241 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.1e-05
    VWA_CoxE  56 kprelvllvDvSgSmaa..ysaiflallhAllqqlprtevfaFdtrlvdlTralrerDpaeaLarvsaaved..lgGgTrigaalaeflelvtrpa 147
                 kp+  + l+DvSgSm+   + ++  +l h ++q++++  +++   r+v   +  +e D +  L+++ +++e    gGgT+ ++a++ +   +tr++
  EFC38207.1 127 KPTLFIALADVSGSMQGrpWEQVCTSLKHFAQQSFNNPAIIC---RMVAYESSAKEIDMKGTLQSIIRNIETafTGGGTDFASAFQLACTIITRES 219
                 5667899********972256667777777777777666554...777777777777888888888555555479**********99999998876 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   6.1    0.0042       5.4       1      42 []      11      51 ..      11      51 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0042
  zf-C3HC4_4  1 CPiCldYLekPvsle.CGhsfClsCisslqkepdgeqllCplC 42
                CPi +++Le+P+ ++ CG  f  + + ++    +    +Cp+C
  EFC38207.1 11 CPISRELLEDPIVVPcCGRAFSRQSLANYFSTIEY--RTCPCC 51
                **************94599****999999999855..599999 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   3.5   0.00093       1.2       3      44 .]      11      52 ..       9      52 .. 0.70
   2 ?   -2.5   0.1       5.3   6.8e+03      28      40 ..     684     695 ..     678     697 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00093
   zf-RING_2  3 CpICleelssadsvlllpCgHvfhreClerwlrssst..CPlCr 44
                CpI   el ++  v+ + Cg  f r+ l++++ + +   CP+Cr
  EFC38207.1 11 CPISR-ELLEDPIVVPC-CGRAFSRQSLANYFSTIEYrtCPCCR 52
                77775.55455556655.7788********964443367****9 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 5.3
   zf-RING_2  28 eClerwlrssstC 40 
                 +C  +w++ ++tC
  EFC38207.1 684 TC-YKWIEDRETC 695
                 68.5999999999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1082 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       784  (0.043728); expected 358.6 (0.02)
Passed bias filter:                      606  (0.0338); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.96u 0.33s 00:00:01.29 Elapsed: 00:00:00.55
# Mc/sec: 5964.15
//
Query:       EFC38208.1  [L=1731]
Description: membrane bound PAS domain-containing adenylate/guanylate cyclase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.7e-51  172.1   0.1    2.1e-50  170.9   0.1    1.7  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.1e-13   51.3   0.3    2.8e-13   50.0   0.3    1.8  1  PAS_9          PAS domain
    8.8e-07   28.9   0.0    2.1e-06   27.7   0.0    1.7  1  PAS            PAS fold
     0.0074   16.3   0.0      0.023   14.7   0.0    1.8  1  PAS_8          PAS domain
  ------ inclusion threshold ------
      0.022   15.0   0.0      0.042   14.1   0.0    1.4  1  PAS_4          PAS fold
      0.099   12.5   0.0      0.099   12.5   0.0    4.3  5  DUF3487        Protein of unknown function (DUF3487)


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  170.9   0.1   7.2e-54   2.1e-50       3     182 ..    1504    1700 ..    1502    1701 .. 0.95

  Alignments for each domain:
  == domain 1  score: 170.9 bits;  conditional E-value: 7.2e-54
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevave 95  
                     +e+ +++t +F+d+vgft++ss++  +e+v lLne+++ fd+l+ +++++k+ktiGday +vsgl+  ++ +ha++++++a + +  +++ +++
     EFC38208.1 1504 SEKLNCITCFFSDMVGFTQMSSNMASHELVGLLNEIVNGFDDLTLKYNIEKIKTIGDAYFAVSGLNeLPDSDHAERMCKFACESFGVIKNYNTK 1597
                     67899************************************************************966899******************99999 PP

  Guanylate_cyc   96 s.k.................eglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevk 171 
                     + +                 +++++rvGi+tGp  +gviG++k+ +d+wG+tvn+Asrmest+ ag+iq+s++tye  +  ++ + e   v+vk
     EFC38208.1 1598 TiEkfirerfennqqqlippHQINIRVGINTGPATSGVIGKRKFAFDLWGDTVNTASRMESTSIAGRIQISRATYERVH--DMYTYEERIVQVK 1689
                     9537899***********************************************************************9..555566679**** PP

  Guanylate_cyc  172 Gkgkletyfle 182 
                     Gkg+ +ty+++
     EFC38208.1 1690 GKGECQTYLIQ 1700
                     ********986 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.0   0.3   9.4e-17   2.8e-13       2     103 ..    1352    1462 ..    1351    1463 .. 0.83

  Alignments for each domain:
  == domain 1  score: 50.0 bits;  conditional E-value: 9.4e-17
       PAS_9    2 dgili.dnpdgrilyaNeaalrllGyspeevlgksitdlf.....vtdpeanerlraaleqgrk........kerevevvlirkngetfwvlltasp 84  
                  dg+++  n++g i  +N+ a +++Gy++ e++g+si+dlf     ++ +++ e + + ++   +        + +++e ++irkn ++f+ +++++ 
  EFC38208.1 1352 DGVAMcWNSKGDIDAFNPVAQTMFGYNKTEIIGTSIFDLFedaikDKVKKSVEAIVQSIR---SnqsnedvsTGETFEGECIRKNKTKFPSKISIFV 1445
                  5667665699******************************87444444444444444444...36669***************************** PP

       PAS_9   85 vkdddgelvgiivilrDit 103 
                  v  +++elv   +++ D t
  EFC38208.1 1446 VLHKGKELVV--CFIADQT 1462
                  **99***999..9999988 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.0   7.1e-10   2.1e-06       4      99 ..    1344    1449 ..    1341    1460 .. 0.72

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 7.1e-10
                  HHHHHHSSSEEEE.EETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHH...HHHHHHHHHHHHTT-ECCCCEEEEC......TTSSEEEEE CS
         PAS    4 raileslpdpifv.vDedgrilyvNaaaeellGlsreevlgkslldliheedda...elaelleqlleqgeesrageisfkl......rdgrpihle 90  
                  +++l++++d++ + ++ +g+i  +N+ a++++G++  e++g s++dl+     +   + +e++ q ++++++++++ + +++      +++++++  
  EFC38208.1 1344 QSVLNASIDGVAMcWNSKGDIDAFNPVAQTMFGYNKTEIIGTSIFDLFEDAIKDkvkKSVEAIVQSIRSNQSNEDVSTGETFegecirKNKTKFPSK 1440
                  667888777775449*********************************8887777777777777777777777777666665555555555555555 PP

                  EEEEEEEET CS
         PAS   91 vraspvrda 99  
                  +    v+++
  EFC38208.1 1441 ISIFVVLHK 1449
                  555555555 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   7.6e-06     0.023       3      50 ..    1343    1389 ..    1341    1407 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 7.6e-06
       PAS_8    3 lralfesspdgiav.vd.lgdrivdvNqaalellGys.adlkgellgqllp 50  
                  +++++++s dg+a+ ++  gd i   N+ a+ ++Gy+  +++g     +++
  EFC38208.1 1343 IQSVLNASIDGVAMcWNsKGD-IDAFNPVAQTMFGYNkTEIIGTS---IFD 1389
                  799**********9669999*.*************9965555533...333 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.0   1.4e-05     0.042       1      59 [.    1347    1406 ..    1347    1424 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.4e-05
       PAS_4    1 ldslpdalavl.dpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrv 59  
                  l+++ d++a++ ++ g + + N+ a+ +fg+   e++G + ++l+ +  ++ +   +++ 
  EFC38208.1 1347 LNASIDGVAMCwNSKGDIDAFNPVAQTMFGYNKTEIIGTSIFDLFEDAIKDKVKKSVEAI 1406
                  678889999999*********************************998777776666555 PP

>> DUF3487  Protein of unknown function (DUF3487)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.5       1.2   3.5e+03      47      66 ..     149     168 ..      98     207 .. 0.61
   2 ?   -2.0   0.5       1.1   3.3e+03      34      56 ..     245     267 ..     235     278 .. 0.64
   3 ?   -3.9   1.1       4.3   1.3e+04      47      68 ..     368     389 ..     341     398 .. 0.50
   4 ?   12.5   0.0   3.3e-05     0.099      66      94 ..     531     562 ..     490     574 .. 0.78
   5 ?   -0.3   1.1      0.31   9.3e+02      33      72 ..     752     791 ..     745     800 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.2
     DUF3487  47 vgslaliptialllvllvvl 66 
                 +gs+++ + ++ ++ +l  +
  EFC38208.1 149 IGSVVISFVGVGFVFILCCV 168
                 44333333333222222222 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.1
     DUF3487  34 vvglvlglllallvgslalipti 56 
                 +v+ ++++ll++l g +++i t 
  EFC38208.1 245 IVFSLASILLIILNGVCLFITTN 267
                 45566677777777766655553 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 4.3
     DUF3487  47 vgslaliptialllvllvvlvg 68 
                 +++  l++++a ++++l vl+g
  EFC38208.1 368 FDYNGLGIGLACFVLVLAVLFG 389
                 4444444444444444444444 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 3.3e-05
     DUF3487  66 lvggkllarlKRgkPdtylyrrlelkla...k 94 
                  + +++l+++KR+kP  y++ ++++kl+   k
  EFC38208.1 531 TFSKSVLSKIKRRKPGLYYKYQINVKLKeiaK 562
                 57889**********************94332 PP

  == domain 5  score: -0.3 bits;  conditional E-value: 0.31
     DUF3487  33 lvvglvlglllallvgslaliptialllvllvvlvggkll 72 
                 +v++++ +ll++++  s+ + +  ++ + +++v+   + +
  EFC38208.1 752 FVAFVLFSLLFFAVCLSMSIYFSYMVTSEVMLVFTSCSTI 791
                 6788888999888888899999999888888888766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1731 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1090  (0.0607954); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.94u 0.32s 00:00:01.26 Elapsed: 00:00:00.52
# Mc/sec: 10080.70
//
Query:       EFC38209.1  [L=2183]
Description: rasGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-53  181.9   0.1    1.2e-53  181.9   0.1    2.9  3  RasGEF    RasGEF domain
    1.6e-32  112.9   2.1    7.7e-32  110.7   0.1    3.2  3  DOCK-C2   C2 domain in Dock180 and Zizimin proteins
    2.6e-22   79.0   1.5    2.6e-22   79.0   1.5    4.4  4  RasGEF_N  RasGEF N-terminal motif


Domain annotation for each model (and alignments):
>> RasGEF  RasGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.2       1.2   7.3e+03      37      58 ..    1124    1145 ..    1107    1203 .. 0.50
   2 ?   -3.0   0.0       1.3   7.5e+03     116     156 ..    1641    1681 ..    1618    1692 .. 0.67
   3 !  181.9   0.1     2e-57   1.2e-53       1     177 []    1921    2099 ..    1921    2099 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.2
      RasGEF   37 eaviarfnrlsnwvaseilsee 58  
                  ++++ +f  + n+v++ i + +
  EFC38209.1 1124 SQMLYHFPVFLNCVMYIIANVK 1145
                  4455555555555555555321 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.3
      RasGEF  116 leeleelmspennfknyrealkssasskpciPflglyltdl 156 
                  ++ +e++ +++++ +n+r++++   +++   P + +++++l
  EFC38209.1 1641 MKYIEQFNQSSQDAENVRKRMDPMLTNTMLTPLFVTIVQKL 1681
                  44566666777777777777777765665557777766666 PP

  == domain 3  score: 181.9 bits;  conditional E-value: 2e-57
      RasGEF    1 elAeqltlieaelfskikpeellgsawsked...rspnveaviarfnrlsnwvaseilseeslkkRakviekfikiakecrklnNfnslmailsaLq 94  
                  e+A+q+tlie+e+f+ki+p+e+l+ aw+k++   ++pn+ ++++r n+++++va +ils+++lk R + i kfi++a+ +r++nNf++l +ils+L+
  EFC38209.1 1921 EIARQITLIEYEYFQKIEPKECLSGAWTKSSkydEAPNIAHLTDRWNKMTQFVACSILSQNDLKIRRRYIIKFIELANALRDINNFHGLSEILSGLS 2017
                  79***************************9966444************************************************************* PP

      RasGEF   95 sspvsrLkktweavskkslktleeleelmspennfknyrealkssasskpciPflglyltdltfieegnpdtlegk.iNfeKrr 177 
                  + +v+rLkktw+ v+ ++l+++e+l++l+s+e+  kn+r+al+ +    pciP l++yl+dltfi++gnpd+++++ iN+ Krr
  EFC38209.1 2018 NVSVYRLKKTWATVPTEYLTLYEDLKKLCSQEQANKNMRQALQLC--LPPCIPPLSMYLKDLTFINDGNPDYIRDGlINVFKRR 2099
                  *******************************************99..7889**********************9999*****97 PP

>> DOCK-C2  C2 domain in Dock180 and Zizimin proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  110.7   0.1   1.3e-35   7.7e-32       4     194 ..     888    1073 ..     886    1074 .. 0.84
   2 ?   -4.0   0.0       1.8   1.1e+04     148     186 ..    1306    1341 ..    1298    1345 .. 0.54
   3 ?   -0.9   0.0       0.2   1.2e+03      84     123 ..    1543    1584 ..    1526    1631 .. 0.68

  Alignments for each domain:
  == domain 1  score: 110.7 bits;  conditional E-value: 1.3e-35
     DOCK-C2    4 vrNdlYvtlksgefsskgskssakniqvtvevrdsdger......lekaiyl.g.....sgeelvsefrsvvlyhnkqptfneeiKialpieltekh 88  
                  +++ lY+ l++++++s    +s k+++v+v +r++d+ +         +i++ g      g + ++++ s+++yh+k p f ++iKi+lp+  +++h
  EFC38209.1  888 FNHVLYILLDNINMTSL--PNSYKSVAVRVLLRENDEMSggvlvgA-SRIFSeGsrnyiGGMDIKQQAISSITYHEKYPLFFDQIKIQLPFPIHDNH 981 
                  7899**********865..578*************55444546743.555543578899999*********************************** PP

     DOCK-C2   89 HLlFtfrhvsceekkk.....ekdkeeeekpfgyaflpLlkedgraflkdgehelpvykk.elppsgYlslpssrtssseeqkgpsekwldnskdtf 179 
                  HL+F+frhvs+++ +          + +++++g+++l+L++++g  f k+g ++lp+yk  +lp+ +Yls              +s +++ n+k++f
  EFC38209.1  982 HLVFEFRHVSSKRGQPvsgvvG---KADTTVIGFSILKLVQDEG--F-KNGMKKLPIYKCtTLPN-NYLSD-------------KSLQKYANGKSIF 1058
                  **********976555996542...45579**********9544..5.***********547888.***63.............34566899***** PP

     DOCK-C2  180 kvrtklcSTiltqde 194 
                  ++++   S+i+++d+
  EFC38209.1 1059 RFNVIAKSSIFPSDK 1073
                  *************97 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 1.8
     DOCK-C2  148 sgYlslpssrtssseeqkgpsekwldnskdtfkvrtklc 186 
                  + Y+s p s++ss+++   ++++   n  d++k++ +l+
  EFC38209.1 1306 ATYFSKPRSNQSSESQE--STVE-EINALDSLKLSWFLF 1341
                  47888776542222222..2222.235777777777665 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.2
     DOCK-C2   84 ltekhHLlFtfrhvsceekkk......ekdkeeeekpfgyaflpLl 123 
                     ++H   +f h+  ++kk+      +     + + + ++f++Ll
  EFC38209.1 1543 NDLQSHFAVSFVHCLRNRKKEewpeiwN----HKSPDVLVSFVKLL 1584
                  3346677777777765444336643322....22345566666665 PP

>> RasGEF_N  RasGEF N-terminal motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.3      0.24   1.4e+03      34      63 ..      32      98 ..      29     133 .. 0.59
   2 ?   -0.1   0.1      0.18   1.1e+03      39      71 ..    1252    1287 ..    1210    1354 .. 0.63
   3 ?   -1.1   0.1      0.36   2.2e+03      53      90 ..    1556    1620 ..    1534    1652 .. 0.56
   4 !   79.0   1.5   4.4e-26   2.6e-22       1      95 [.    1759    1848 ..    1759    1858 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.24
    RasGEF_N 34 sFttpaeLlekLierye........inppnnlesdes..............................n 63
                 F+   +Ll++L ++ +        i +++++e++ +                              +
  EFC38209.1 32 KFFDLDQLLDNLRQFPVvllktvneIAEQQKKEQE-EfypshddyvddeslndiqsiesddeentpsP 98
                57778899999999999999988874444444333.12355555555555655544444433333331 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.18
    RasGEF_N   39 aeLlekLierye................inppnnlesdesnswnsksss 71  
                  + ++ +L+er+e                ++             ns++++
  EFC38209.1 1252 TSFCLLLAERWEeffkschtketesrtkES-------------NSNTTE 1287
                  567889999999988776555444333211.............111111 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.36
    RasGEF_N   53 ppnnlesdes.nswnsksssn..........................irlrvlsvlkewvenhyy 90  
                  +  n++++e  + wn ks +                           i+  v+++l + +e+ ++
  EFC38209.1 1556 CLRNRKKEEWpEIWNHKSPDVlvsfvkllsiainkhiaypvrvtrrmIKTIVIEILVCFIEQKWE 1620
                  44444444332334444333343444444444444444444444444455566666666666665 PP

  == domain 4  score: 79.0 bits;  conditional E-value: 4.4e-26
    RasGEF_N    1 qvkagtlekLierLtskrlldddfletFLltyrsFttpaeLlekLieryeinppnnlesdesnswnsksssnirlrvlsvlkewvenhyydfsdd 95  
                  q+ka+tl+kLie++ts + +d++f  +F+ltyrsF++++ L++kLi+r++i ++++++       + + ++++ lrv++++k wve++++df++ 
  EFC38209.1 1759 QIKAATLDKLIEKITSDKETDPKFRDVFFLTYRSFCSSHVLMDKLIDRFNIAEEQKKQDI-----QPEANTKVLLRVINAVKMWVEKYFHDFDNL 1848
                  79***********************************************76555444333.....3344445888*****************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1280  (0.0713927); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.16u 0.35s 00:00:01.50 Elapsed: 00:00:00.55
# Mc/sec: 12004.40
//
Query:       EFC38210.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.4e-14   51.9  22.0    2.8e-08   33.2   2.1    4.2  4  Hexapep    Bacterial transferase hexapeptide (six repeats)
    2.2e-06   27.3   3.8    2.2e-06   27.3   3.8    3.4  4  Hexapep_2  Hexapeptide repeat of succinyl-transferase


Domain annotation for each model (and alignments):
>> Hexapep  Bacterial transferase hexapeptide (six repeats)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.5   1.5e-06     0.013       7      36 .]     139     168 ..     138     168 .. 0.96
   2 !    3.8   0.3    0.0059        53      18      35 ..     171     188 ..     170     189 .. 0.81
   3 !   13.5   0.9   4.9e-06     0.044      12      30 ..     200     218 ..     198     219 .. 0.88
   4 !   33.2   2.1   3.1e-12   2.8e-08       2      34 ..     219     251 ..     218     253 .. 0.95

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.5e-06
                 TEEE-TTEEEETTEEE-TTEEEETTEEEES CS
     Hexapep   7 nvlIgpfaviggnVkIGdnvkIgagvvigg 36 
                 +v++ p a++ g+V + d+v ++ ++v++g
  EFC38210.1 139 GVWVAPSATVIGDVRLCDHVNVWYNAVLRG 168
                 79*************************986 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.0059
                 TTEEE-TTEEEETTEEEE CS
     Hexapep  18 gnVkIGdnvkIgagvvig 35 
                 + ++IG ++ I  gvvi+
  EFC38210.1 171 NSIEIGGYTNIQDGVVIT 188
                 567899999999999997 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 4.9e-06
                 TTEEEETTEEE-TTEEEET CS
     Hexapep  12 pfaviggnVkIGdnvkIga 30 
                 +++vigg+++IG +vk++a
  EFC38210.1 200 SNVVIGGHTTIGHGVKLHA 218
                 7999**********99988 PP

  == domain 4  score: 33.2 bits;  conditional E-value: 3.1e-12
                 EEEETTEEE-TTEEEETTEEE-TTEEEETTEEE CS
     Hexapep   2 tvIGsnvlIgpfaviggnVkIGdnvkIgagvvi 34 
                 ++IG+ ++Ig++a+i+++++I dnv+I+ag+ +
  EFC38210.1 219 CRIGNECVIGMNATILEGAVIEDNVVIAAGSLV 251
                 79****************************987 PP

>> Hexapep_2  Hexapeptide repeat of succinyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0      0.65   5.8e+03      15      23 ..     147     157 ..     144     160 .. 0.61
   2 ?    1.9   0.2     0.021   1.9e+02      13      26 ..     171     187 ..     170     189 .. 0.82
   3 ?    1.7   0.1     0.024   2.2e+02       7      25 ..     201     215 ..     200     218 .. 0.49
   4 !   27.3   3.8   2.4e-10   2.2e-06       3      31 ..     220     250 ..     219     252 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.65
                 E.ES.EEE-TT CS
   Hexapep_2  15 g.iG.vslGdn 23 
                 + iG v l+d 
  EFC38210.1 147 TvIGdVRLCDH 157
                 43655888875 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.021
                 T-E.ES..EEE-TT-EE CS
   Hexapep_2  13 nag.iG..vslGdncvv 26 
                 n++ iG  +++ d++v+
  EFC38210.1 171 NSIeIGgyTNIQDGVVI 187
                 88877669999999998 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.024
                 T-EE-TT-EESEEE-TT-E CS
   Hexapep_2   7 nCliGanagiGvslGdncv 25 
                 n++iG   +i    G +++
  EFC38210.1 201 NVVIGGHTTI----GHGVK 215
                 5555555555....44444 PP

  == domain 4  score: 27.3 bits;  conditional E-value: 2.4e-10
                 EE-TT-EE-TT-EE..SEEE-TT-EE-TT-E CS
   Hexapep_2   3 iIGdnCliGanagi..GvslGdncvvgaGvv 31 
                 +IG+ C+iG na+i  G  ++dn+v++aG+ 
  EFC38210.1 220 RIGNECVIGMNATIleGAVIEDNVVIAAGSL 250
                 7************999*************85 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       510  (0.0284455); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 2193.16
//
Query:       EFC38211.1  [L=452]
Description: hypothetical protein NAEGRDRAFT_74042 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-12   44.7   0.4    3.8e-11   42.8   0.1    2.0  2  LRR_9     Leucine-rich repeat
    6.2e-08   32.8   0.2    4.1e-06   27.0   0.1    3.1  3  LRR_4     Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
      0.012   15.4   0.1      0.029   14.1   0.1    1.7  1  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.25   1.5e+03      94     117 ..       5      28 ..       2      44 .. 0.82
   2 !   42.8   0.1   6.3e-15   3.8e-11      88     164 ..      52     127 ..      43     133 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.25
       LRR_9  94 vltnnelqeladldPlaslkklel 117
                 vlt+n +   + ld +a++k+l++
  EFC38211.1   5 VLTKNFILGKTRLDNIANVKNLNF 28 
                 788999888899999999999876 PP

  == domain 2  score: 42.8 bits;  conditional E-value: 6.3e-15
       LRR_9  88 PnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldfrkvklkereeaeklfks 164
                  +l+el l +n+++ela+++ l +lk+l++l l  np ++ ++yrl+vi  l+ l+ ld   + ++er++a++ fk+
  EFC38211.1  52 QKLRELYLRKNKIEELAEVEYLKELKNLKVLWLAGNPCADVENYRLRVISFLDGLTKLDDDDITNEERDQAKQ-FKG 127
                 5799******************************************************************976.565 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.04   2.4e+02       2      31 ..      22      51 ..      21      53 .. 0.86
   2 !   27.0   0.1   6.9e-10   4.1e-06       1      36 [.      52      89 ..      52      96 .. 0.82
   3 ?   -0.6   0.0      0.35   2.1e+03      12      25 ..      96     109 ..      91     111 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.04
                S--EEE--SS---E-S-HHH-TT--EEE-. CS
       LRR_4  2 nLevLdLsnNqltdiplleklpnLkeLdLs 31
                n ++L++ +  ltd++ ++ +p  ++++Ls
  EFC38211.1 22 NVKNLNFWGQELTDVSIISEMPFVEVVSLS 51
                77899999768******888**99999996 PP

  == domain 2  score: 27.0 bits;  conditional E-value: 6.9e-10
                SS--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36
                ++L++L+L+ N++ ++     l+ l+nLk+L+L gN + 
  EFC38211.1 52 QKLRELYLRKNKIEELAEveyLKELKNLKVLWLAGN-PC 89
                69**********999999655556*********999.44 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.35
                 ---E-S-HHH-TT- CS
       LRR_4  12 qltdiplleklpnL 25 
                 +l+ i++l +l++L
  EFC38211.1  96 RLRVISFLDGLTKL 109
                 78889997777766 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.1   4.9e-06     0.029       2      36 ..      53      88 ..      52     110 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 4.9e-06
                T-SEEE-TTS--SEE-.TTSSTT-TT--EEE--SS- CS
       LRR_8  2 nLtsLdLsnNrltsld.deaFkglsnLkvLdLsnNl 36
                +L++L+L++N++++l   e  k l+nLkvL L  N 
  EFC38211.1 53 KLRELYLRKNKIEELAeVEYLKELKNLKVLWLAGNP 88
                79999******999962588888*****99999994 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (452 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1038  (0.057895); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 2994.98
//
Query:       EFC38212.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.1e-27   95.4   0.1    5.6e-27   94.6   0.1    1.4  1  Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransf


Domain annotation for each model (and alignments):
>> Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransferase) C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.6   0.1   3.1e-31   5.6e-27       1     161 [.     242     416 ..     242     427 .. 0.76

  Alignments for each domain:
  == domain 1  score: 94.6 bits;  conditional E-value: 3.1e-31
  Glyco_transf_10   1 kkklvawvvsncktk...skRekyvkeLkkhlevdvyGkcgklkveelsekeveelikkykFYLafEnsickDYiTeKlw...naleaga.vPv 87 
                      k+k v+ ++snc++    ++R +++++L+++++++ yG cgk+  +e +  +  el ++++FY+a+Ens+ +DY+ eK++   +al++ga + +
       EFC38212.1 242 KNKGVCAFISNCHNGdlaKSRYQLLTKLSEYVPIHQYGACGKNI-QEGHGGKQFELDNNCRFYFAVENSMVTDYVSEKFFeglKALQNGAkLMM 334
                      8999********9988889*********************9776.889999999**************************55556664432556 PP

  Glyco_transf_10  88 vlGparenyerfvppdsfihvddFkspkelaeyLkkldkneeeYleYfeWrkkykv......kkkeeleee.........lCklCeklk 161
                      ++ +a +  e   pp+sfi++ddF+sp++l eyLk+++++e+  +++ +   + +       +                  C++C+++ 
       EFC38212.1 335 IYKGAPNFKEWNFPPNSFINIDDFESPEKLGEYLKSINDDEAFEKRFNQITLSDQKhidkavR-------DldyrlgqniPCRICKSIG 416
                      6655544455679************************87766555554433222221222221.......1233445555888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       604  (0.0336884); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 3403.89
//
Query:       EFC38213.1  [L=461]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-30  105.8   0.2    4.1e-30  104.8   0.2    1.5  2  Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransf


Domain annotation for each model (and alignments):
>> Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransferase) C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.3   0.0      0.74   1.3e+04      52      65 ..     141     154 ..     123     159 .. 0.69
   2 !  104.8   0.2   2.3e-34   4.1e-30       2     163 ..     216     391 ..     215     400 .. 0.81

  Alignments for each domain:
  == domain 1  score: -4.3 bits;  conditional E-value: 0.74
  Glyco_transf_10  52 elikkykFYLafEn 65 
                      + +++  FY+ +E+
       EFC38213.1 141 RRMRRLSFYINVES 154
                      55667777777775 PP

  == domain 2  score: 104.8 bits;  conditional E-value: 2.3e-34
  Glyco_transf_10   2 kklvawvvsncktk...skRekyvkeLkkhlevdvyGkcgklkveelsekeveelikkykFYLafEnsickDYiTeKlw...nale.agavPvv 88 
                      ++ ++ ++snc+ +   s+R k++++L+k+++v  yGkcg++   e++  ++ el++++k Y+a+Ens+  DYiTeKl+   +a+e  g + +v
       EFC38213.1 216 RSGICAFISNCAFEshaSQRLKILETLSKYIPVRQYGKCGRNA-YETKGGKMFELEHNCKIYFAMENSVVPDYITEKLYegfKAMEnGGRLLMV 308
                      567899*****9887789*********************9888.8899999***************************9444455533456666 PP

  Glyco_transf_10  89 lGparenyerfvppdsfihvddFkspkelaeyLkkldkneeeYleYfeWrkkykvkkkeeleee........lCklCeklkek 163
                      + ++ +  +   p+++fi+vddF+s++el +yLkkl++ne+e+++ f+  ++ +v+ ++ ++ +         C++C+ + ++
       EFC38213.1 309 YKGPPNIADFKYPKSAFINVDDFSSIDELGQYLKKLNENEDEFNKRFSELERDRVQINHAIKMMkpslknylPCRMCQVVGQT 391
                      655535555558***********************************987777774333333334467777789999988754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (461 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       764  (0.0426125); expected 358.6 (0.02)
Passed bias filter:                      584  (0.0325729); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 2737.65
//
Query:       EFC38214.1  [L=350]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.9e-12   45.2   5.2    7.1e-12   44.7   5.2    1.2  1  Glyco_transf_18  Glycosyltransferase family 18
  ------ inclusion threshold ------
        0.1   11.9   0.0       0.17   11.2   0.0    1.2  1  STALD            Sir2- and TIR-associating SLOG family


Domain annotation for each model (and alignments):
>> Glyco_transf_18  Glycosyltransferase family 18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.7   5.2   7.9e-16   7.1e-12     467     558 .]     257     347 ..     234     347 .. 0.90

  Alignments for each domain:
  == domain 1  score: 44.7 bits;  conditional E-value: 7.9e-16
  Glyco_transf_18 467 lsalrvlkaeegqsCkeaCqekelvCepaffkllnkkealarlevkcestese.vnhlfPaysekereCllqsdalLfsCagseeklrrlCPC 558
                      l+++++++++ g+ C ++C ++e vC p++f+++n+ +++ ++  +ce +++  +++ +P ++   + C++ + +  f C +++++ rrlCPC
       EFC38214.1 257 LQTIKAVLGALGENCDTICAKSESVCAPNYFPYINRCDEMRKHYSSCECKKEGvIDSRAPYFDG--KYCIIGNRRSKFRCGNAHPSERRLCPC 347
                      577899999**************************************98776515777999986..89************************* PP

>> STALD  Sir2- and TIR-associating SLOG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   1.9e-05      0.17      74     148 ..     119     196 ..     102     205 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 1.9e-05
       STALD  74 GlgvGsavinGvleeiyekkkkkledrlilrpfpqaae...eekekkelwekyReeliseaGiaifvfGnkkkdgeiv 148
                 G+ + ++ i G++++++ ++k+    + +l  f ++     +e  k++++  yR +l+++ G++  v  n++++++++
  EFC38214.1 119 GVIIHKSDIPGFMNYMEANRKRAFPTDWLLEEFVNKYVpmgQEYFKERVFYTYRYQLMEHIGVVTSVGNNRNEEQNKI 196
                 7778888899***********************9875411144456799**************999988887776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       520  (0.0290033); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2110.50
//
Query:       EFC38215.1  [L=623]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.2e-21   75.8  17.2      0.003   18.4   0.0   10.8 11  WD40          WD domain, G-beta repeat
    4.5e-13   49.3   0.4      0.002   18.4   0.0    6.6  7  ANAPC4_WD40   Anaphase-promoting complex subunit 4 WD40 domai
    1.6e-08   34.2  11.1    0.00098   18.5   3.2    4.2  3  WD40_like     WD40-like domain
      9e-06   25.4   0.2     0.0057   16.3   0.0    3.2  3  PQQ_2         PQQ-like domain
    0.00066   18.3   0.8       0.48    8.9   0.0    3.9  4  Cytochrom_D1  Cytochrome D1 heme domain
     0.0011   18.8   1.2      0.087   12.8   0.0    4.0  4  PQQ           PQQ enzyme repeat
  ------ inclusion threshold ------
      0.016   15.7   1.8        5.8    7.5   0.1    5.3  6  PQQ_3         PQQ-like domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   1.2e-06     0.003       4      38 .]      49      86 ..      46      86 .. 0.89
   2 !   15.0   0.0   1.4e-05     0.035       2      38 .]      91     130 ..      90     130 .. 0.85
   3 ?    1.1   0.0      0.32   8.2e+02      25      38 .]     170     182 ..     153     182 .. 0.84
   4 ?    2.4   0.0      0.13   3.3e+02      14      32 ..     205     223 ..     194     227 .. 0.84
   5 !    6.5   0.1    0.0067        17      13      38 .]     247     272 ..     237     272 .. 0.66
   6 ?   -2.1   0.0       3.4   8.8e+03       9      19 ..     324     335 ..     320     348 .. 0.81
   7 ?    2.2   0.1      0.15   3.9e+02      13      35 ..     381     403 ..     368     405 .. 0.65
   8 !   12.9   0.0   6.4e-05      0.16       3      37 ..     412     448 ..     410     448 .. 0.87
   9 !   10.7   0.0   0.00031       0.8       2      38 .]     454     491 ..     453     491 .. 0.88
  10 ?    2.0   0.1      0.17   4.3e+02      13      37 ..     508     532 ..     501     533 .. 0.78
  11 ?    4.7   0.0     0.024        61       8      29 ..     590     610 ..     581     619 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.2e-06
                EEEEESS.SSEEEEEEETTSSEEEEE..ETTSEEEEEE CS
        WD40  4 lrtltGH.ssvtslafspdgawlasG..sdDgtvriWd 38
                ++ l+GH +  t+la s +g+ +a+G  +++  + +Wd
  EFC38215.1 49 QQFLRGHdDTLTCLAISNNGQVIATGqkGENADCCLWD 86
                6779***655****************9999*******8 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.4e-05
                 EEEEEEESS.SSEEEEEEETTSSEEEE.E.ETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlas.G.sdDgtvriWd 38 
                 q+++ l  H +sv ++afs+d +++a+ G   D+ + iW+
  EFC38215.1  91 QLVHRLAEHeQSVGACAFSHDDKLIATvGnATDRRLLIWS 130
                 67899999*999*************9734435*******5 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.32
                 EEEEETTSEEEEEE CS
        WD40  25 lasGsdDgtvriWd 38 
                 la++s  g++ +W+
  EFC38215.1 170 LATCS-GGSIILWS 182
                 89***.*******5 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.13
                 EEEEEETTSSEEEEEETTS CS
        WD40  14 tslafspdgawlasGsdDg 32 
                 t+++f++ g +l sGs  g
  EFC38215.1 205 TCMQFDKMGEFLYSGSTSG 223
                 89*************8544 PP

  == domain 5  score: 6.5 bits;  conditional E-value: 0.0067
                 EEEEE.EETTSSEEEEEETTSEEEEEE CS
        WD40  13 vtsla.fspdgawlasGsdDgtvriWd 38 
                 v sl+   ++g+ + +G+ Dgtv ++d
  EFC38215.1 247 VLSLSiDTSNGNII-AGGGDGTVTLFD 272
                 66677333455555.5655****9987 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 3.4
                 SS.SSEEEEEEE CS
        WD40   9 GH.ssvtslafs 19 
                  H ++v++++f+
  EFC38215.1 324 NHsKDVYAVDFP 335
                 59889**99765 PP

  == domain 7  score: 2.2 bits;  conditional E-value: 0.15
                 EEEEEEETTSSE.EEEE.ETTSEEE CS
        WD40  13 vtslafspdgaw.lasG.sdDgtvr 35 
                 v s++f +d    l++G s Dg++r
  EFC38215.1 381 V-SCSFIKDDISiLLTGwS-DGSIR 403
                 4.44444444442679***.****8 PP

  == domain 8  score: 12.9 bits;  conditional E-value: 6.4e-05
                 EEEEEE.SS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   3 clrtlt.GH.ssvtslafspdgawlasGsdDgtvriW 37 
                 +l+tl  +H + vt +++s ++++++s++  g vr++
  EFC38215.1 412 QLWTLAnAHrNAVTKIDTSFNNKFFVSAGQEGDVRVY 448
                 66777449*999***********************97 PP

  == domain 9  score: 10.7 bits;  conditional E-value: 0.00031
                 EEEEEEESSSS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGHss.vtslafspdgawlasGsdDgtvriWd 38 
                 q++ +++ H+  vt+l+   d   ++s+s+D+ +  +d
  EFC38215.1 454 QLVCSFKEHTTmVTCLQILEDDVHVFSSSKDREIFCYD 491
                 78899****557*****9999999********998776 PP

  == domain 10  score: 2.0 bits;  conditional E-value: 0.17
                 EEEEEEETTSSEEE.EEETTSEEEEE CS
        WD40  13 vtslafspdgawla.sGsdDgtvriW 37 
                 v+++ +++d+  ++  Gs D+ + +W
  EFC38215.1 508 VNGFVVCKDHETIIsIGS-DRYITFW 532
                 777777788888762599.****999 PP

  == domain 11  score: 4.7 bits;  conditional E-value: 0.024
                 ESSSSEEEEEEETTSSEEEEEE CS
        WD40   8 tGHssvtslafspdgawlasGs 29 
                 +G+ ++ sl+fspd + l++ +
  EFC38215.1 590 EGQ-FIFSLRFSPDDRQLICVG 610
                 355.79***********99756 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.1    0.0017       4.5      36      81 ..      54     101 ..      47     106 .. 0.84
   2 !    7.5   0.1     0.002         5      31      81 ..      95     145 ..      89     158 .. 0.74
   3 ?    0.4   0.0      0.32   8.2e+02      42      71 ..     205     234 ..     179     245 .. 0.80
   4 ?   -2.3   0.0       2.2   5.7e+03      49      69 ..     256     275 ..     243     292 .. 0.70
   5 !    8.8   0.0   0.00074       1.9      49      87 ..     389     427 ..     380     428 .. 0.87
   6 !   18.4   0.0   7.6e-07     0.002      26      88 ..     410     470 ..     409     474 .. 0.93
   7 !    5.6   0.0    0.0075        19      12      69 ..     566     622 ..     558     623 .] 0.80

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0017
  ANAPC4_WD40  36 kedsevrsLaWkpdgklLavays..dgevrlldaesgkvvhslsvkse 81 
                  ++d + ++La +++g+++a + +  +  + l da+s ++vh l  +++
   EFC38215.1  54 GHDDTLTCLAISNNGQVIATGQKgeNADCCLWDAQSLQLVHRLAEHEQ 101
                  4788999*************9853267999***********9987776 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.002
  ANAPC4_WD40  31 tleedkedsevrsLaWkpdgklLavays..dgevrlldaesgkvvhslsvkse 81 
                   l  ++++++v + a+++d+kl+a + +  d ++ + ++++g+vv s s  ++
   EFC38215.1  95 RL--AEHEQSVGACAFSHDDKLIATVGNatDRRLLIWSVQTGNVVASASLPKQ 145
                  55..678999*************98754126688999********98776444 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.32
  ANAPC4_WD40  42 rsLaWkpdgklLavaysdgevrlldaesgk 71 
                  +++++ + g++L  +   g +++++   +k
   EFC38215.1 205 TCMQFDKMGEFLYSGSTSGDLSFIHTRLKK 234
                  58999**************99999976655 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 2.2
  ANAPC4_WD40  49 dgklLavaysdgevrlldaes 69 
                  +g++   +  dg+v l+d ++
   EFC38215.1 256 NGNI-IAGGGDGTVTLFDGQN 275
                  4444.4577899999988655 PP

  == domain 5  score: 8.8 bits;  conditional E-value: 0.00074
  ANAPC4_WD40  49 dgklLavaysdgevrlldaesgkvvhslsvksekavtcl 87 
                  d ++L  ++sdg++r +d e+g+ + +l  ++ +avt++
   EFC38215.1 389 DISILLTGWSDGSIRAVDCETGEQLWTLANAHRNAVTKI 427
                  557999*******************99988888888876 PP

  == domain 6  score: 18.4 bits;  conditional E-value: 7.6e-07
  ANAPC4_WD40  26 gqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclg 88 
                  g+++wtl ++++ + v+++  + ++k+++ a ++g vr++ +++ ++v s++ +++  vtcl+
   EFC38215.1 410 GEQLWTL-ANAHRNAVTKIDTSFNNKFFVSAGQEGDVRVYAMKTRQLVCSFKEHTT-MVTCLQ 470
                  5789999.89999****************************************999.6***97 PP

  == domain 7  score: 5.6 bits;  conditional E-value: 0.0075
  ANAPC4_WD40  12 latedgellvfRlng.qrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaes 69 
                  +  +d+ ++vf ++  +++ t+  ++e++ + sL+++pd++ L  + + g + l+++++
   EFC38215.1 566 IFGTDEAIHVFDVDTcEKITTI--STEGQFIFSLRFSPDDRQLICVGEGGVMLLFNVYD 622
                  5556778888888654788888..89999************999999999888888876 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.0   0.00012       0.3       6      59 ..      62     117 ..      58     170 .. 0.80
   2 !    6.6   0.4    0.0016       4.2       6      82 ..     252     326 ..     246     338 .. 0.57
   3 !   18.5   3.2   3.8e-07   0.00098       4     183 ..     425     617 ..     422     619 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00012
   WD40_like   6 idiskkgslilyG..gkddkctvlkleslesvsivesfedSvifvklldddlilvv 59 
                 + is++g++i+ G  g++  c + + +sl++v  +++ e+Sv  + + +dd+++ +
  EFC38215.1  62 LAISNNGQVIATGqkGENADCCLWDAQSLQLVHRLAEHEQSVGACAFSHDDKLIAT 117
                 5699*********44456679***************************99987643 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0016
   WD40_like   6 idiskkgslilyGgkddkctvlkleslesvsivesfedSvifvklldddlilvvtlDGtillsllenee.evenekie 82 
                 id    +  i+ Gg d ++t+++ ++  +++ + s    v  +   + + +l++t  G i++s + + + +   ++  
  EFC38215.1 252 IDT--SNGNIIAGGGDGTVTLFDGQNILKKQKISSRGGVV-TISSFQSEFMLIGTDGGEIIKSSMDKLDvSLVARNHS 326
                 444..33346667777777777777776666666654444.4444466677777777777777665433234344444 PP

  == domain 3  score: 18.5 bits;  conditional E-value: 3.8e-07
   WD40_like   4 YsidiskkgslilyGgkddkctvlkleslesvsivesfedSvifvkllddd.lilvvtlDGtillslleneeevenekie....edistvkviddklli 97 
                   id s+++++++  g++  ++v+ +++ ++v ++++ +  v   ++l+dd ++   + D  i  ++l+ne  v   +++    +   ++k  +  + i
  EFC38215.1 425 TKIDTSFNNKFFVSAGQEGDVRVYAMKTRQLVCSFKEHTTMVTCLQILEDDvHVFSSSKDREIFCYDLRNERRVAAFNMKvgsvNGFVVCKDHETIISI 523
                 579************************************************77788999*************877655543222445566667777899 PP

   WD40_like  98 GtnkG.siyvfskdlqleevllgqsseIkeikienn..kiysL..sesafivfdlfsqnieykisvkdiktfeii...enkdilligtegeili 183
                 G+++  + ++ s d  +++v  +++ e k i ++n    ++ +  +++a  vfd+++ ++ + is ++  +f+     ++++++++g+ g +l+
  EFC38215.1 524 GSDRYiTFWTISSDSPTRIVPYSKKFEPKCIAKTNTsdSMFVIfgTDEAIHVFDVDTCEKITTISTEGQFIFSLRfspDDRQLICVGEGGVMLL 617
                 9988624556999999999999999998888877542234444225677889999999999999999999998755557888999998877665 PP

>> PQQ_2  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.1   0.1    0.0056        14      76     166 ..      67     161 ..      47     189 .. 0.61
   2 ?   -1.3   0.0       0.5   1.3e+03     130     138 ..     264     272 ..     173     337 .. 0.66
   3 !   16.3   0.0   2.2e-06    0.0057     126     233 ..     394     497 ..     371     521 .. 0.62

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0056
       PQQ_2  76 egrvvvvasdg...qlialdaedGkrlWstqqrseepaelrssaspava.gdtvvvges...sgklvaldpkdGkvlWerelaaprgtsels...rvgd 164
                 +g+v++  ++g     +  da++ +++++ ++++       s++++a++ +d++++      + +l + ++++G+v+ +++l +++  + +     v+d
  EFC38215.1  67 NGQVIATGQKGenaDCCLWDAQSLQLVHRLAEHE------QSVGACAFShDDKLIATVGnatDRRLLIWSVQTGNVVASASLPKQTDKVIVCfggMVRD 159
                 4444444433323344445555555555533222......34556666664554444434567888888888888888888877665554445555555 PP

       PQQ_2 165 is 166
                 i 
  EFC38215.1 160 IK 161
                 55 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.5
       PQQ_2 130 ssgklvald 138
                  +g ++ +d
  EFC38215.1 264 GDGTVTLFD 272
                 333333333 PP

  == domain 3  score: 16.3 bits;  conditional E-value: 2.2e-06
       PQQ_2 126 vvgessgklvaldpkdGkvlWerelaaprgtselsrvgdisgrpvvaegtVyassgqgrllal.dlatgrrlwskeiss..inglpildgdllyvvs.a 220
                 + g s+g + a+d ++G++lW  + a  +  +       ++   ++ +++ ++s+gq++ + +  ++t + + s + ++  ++ l+il++d+ + +s +
  EFC38215.1 394 LTGWSDGSIRAVDCETGEQLWTLANAHRN--A-------VTKIDTSFNNKFFVSAGQEGDVRVyAMKTRQLVCSFKEHTtmVTCLQILEDDVHVFSSsK 483
                 44556777777777777777776443322..1.......222233334666666666655555344444422344433333666677777666666634 PP

       PQQ_2 221 .gelialdratGav 233
                   e++++d+ + ++
  EFC38215.1 484 dREIFCYDLRNERR 497
                 77777777776655 PP

>> Cytochrom_D1  Cytochrome D1 heme domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0     0.059   1.5e+02      87     324 ..      67     110 ..      29     173 .. 0.63
   2 ?    2.0   0.0     0.023        60      80     120 ..     250     287 ..     191     323 .. 0.60
   3 ?    1.6   0.1     0.031        79       4      79 ..     432     507 ..     429     525 .. 0.83
   4 !    8.9   0.0   0.00019      0.48       5      64 ..     561     620 ..     557     623 .] 0.83

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.059
                   TTSEEEEEEE.ETTEEEEEETTT--EEEEEE--EE-SSSS---EEEEEE-SSSSEEEEEETTTTEEEEEE-SSSSSEEEEEEE--SSEEEEEE-TTS CS
  Cytochrom_D1  87 ddryvivgnY.lPgqlvildaetLelvkvisargltvderesRVaaivasperpefvvnlkdtgeillvdysdlknlktrtieaakflhDggldpdk 182
                   +++ +++g+  +  +  + da+ L+lv+ ++  +++v+                                                           
    EFC38215.1  67 NGQVIATGQKgENADCCLWDAQSLQLVHRLAEHEQSVGA---------------------------------------------------------- 105
                   444444443213444444555555555544444444433.......................................................... PP

                   SEEEEEEGGGTEEEEEETTTTEEEEEEE-SSSBEETTEEEEEETTTEEEEEEEBSSSSEEEEEE--TTT.-TTTBTSEEEEEE-SSS---EE--TT- CS
  Cytochrom_D1 183 RYflaaanaedkvavvdtkegklvilldvgktphklrvanmvHlelGpvWttshkgdfvvsligtdsesvldeqaWkvvkeikveGqglFvkthpds 279
                                                                                                                    
    EFC38215.1   - -------------------------------------------------------------------------------------------------   -
                   ................................................................................................. PP

                   SEEEEE-TT-SSHT-EEEEETTBT-EEE-HHHHHT--EEEEEE-T CS
  Cytochrom_D1 280 kqlwvdaflnpdndsvaviDkktlekvltlaesaglkvvhvEfnk 324
                                                             f++
    EFC38215.1 106 ----------------------------------------CAFSH 110
                   ........................................33333 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.023
                   EEEEE--TTSEEEEEEEETTEEEEEETTT--EEEEEE--EE CS
  Cytochrom_D1  80 rsvavSqddryvivgnYlPgqlvildaetLelvkvisargl 120
                    s+++S+ +  +++g    g+++++d++++   ++is+rg 
    EFC38215.1 250 LSIDTSN-GNIIAGGG--DGTVTLFDGQNILKKQKISSRGG 287
                   5555553.22333332..35555555555555555555543 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.031
                   GGEEEEEEGGGTEEEEEETTT-SEEEEEE-STTEEEEEE-TT.SSEEEEEETTSEEEEEESSSSSEEEEEE-SSEE CS
  Cytochrom_D1   4 knlfvvverdagkvalldgdskeilavletgyalHisrvfasdgRyvyvigRDgkvtliDLwakeivaevkiGlna 79 
                   +n f v   ++g+v++   ++ + +  ++ +  + +     +d+ +v+  ++D ++  +DL +++ va  ++ + +
    EFC38215.1 432 NNKFFVSAGQEGDVRVYAMKTRQLVCSFKEHTTMVTCLQILEDDVHVFSSSKDREIFCYDLRNERRVAAFNMKVGS 507
                   5678888888999999999999999999999999999999999**********************88865554444 PP

  == domain 4  score: 8.9 bits;  conditional E-value: 0.00019
                   GEEEEEEGGGTEEEEEETTT-SEEEEEE-STTEEEEEE-TT.SSEEEEEETTSEEEEEES CS
  Cytochrom_D1   5 nlfvvverdagkvalldgdskeilavletgyalHisrvfasdgRyvyvigRDgkvtliDL 64 
                   +   v+   +  +++ d d+ e++ ++ t+++   s  f++d+R +  +g  g + l+ +
    EFC38215.1 561 DSMFVIFGTDEAIHVFDVDTCEKITTISTEGQFIFSLRFSPDDRQLICVGEGGVMLLFNV 620
                   444466667789*************************************99887766555 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.19   4.9e+02      23      36 ..     128     141 ..     127     143 .. 0.85
   2 ?   -0.5   0.1      0.55   1.4e+03       1      16 [.     257     272 ..     257     274 .. 0.89
   3 !   12.8   0.0   3.4e-05     0.087       9      25 ..     399     415 ..     394     422 .. 0.88
   4 ?   -2.3   0.0       2.1   5.3e+03       3      19 ..     478     494 ..     477     494 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.19
                 EEEEESSSCGSSES CS
         PQQ  23 lWrfktggpvlslp 36 
                 +W+++tg++v s +
  EFC38215.1 128 IWSVQTGNVVASAS 141
                 8********99877 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.55
                 TEEEEEETTSEEEEEE CS
         PQQ   1 gvvylgsadGylyAlD 16 
                 g++++g  dG++  +D
  EFC38215.1 257 GNIIAGGGDGTVTLFD 272
                 79999******99887 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 3.4e-05
                 TSEEEEEETTTCCEEEE CS
         PQQ   9 dGylyAlDadTGkvlWr 25 
                 dG ++A+D +TG+ lW+
  EFC38215.1 399 DGSIRAVDCETGEQLWT 415
                 9***************8 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 2.1
                 EEEEETTSEEEEEETTT CS
         PQQ   3 vylgsadGylyAlDadT 19 
                 v+  s+d  ++ +D+++
  EFC38215.1 478 VFSSSKDREIFCYDLRN 494
                 667789999*****975 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.27     7e+02       3      17 ..     127     140 ..     126     157 .. 0.71
   2 ?    7.5   0.1    0.0022       5.8      19      37 ..     254     272 ..     237     275 .. 0.85
   3 ?    0.0   0.0      0.53   1.4e+03      29      40 .]     397     409 ..     388     409 .. 0.78
   4 ?   -2.3   0.0       2.7     7e+03       1       7 [.     410     416 ..     410     449 .. 0.70
   5 ?   -1.5   0.0       1.6   4.2e+03      23      39 ..     477     493 ..     472     494 .. 0.80
   6 ?   -2.0   0.0       2.3   5.9e+03      24      40 .]     565     580 ..     554     580 .. 0.71

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.27
       PQQ_3   3 vlWsvqlpgpvnssp 17 
                 ++Wsvq++  v++s+
  EFC38215.1 127 LIWSVQTGN-VVASA 140
                 68*****96.44554 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0022
       PQQ_3  19 vdgglvyvgtgdGtlyAlD 37 
                 +++g + +g+gdGt++ +D
  EFC38215.1 254 TSNGNIIAGGGDGTVTLFD 272
                 679*************999 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.53
       PQQ_3  29 g.dGtlyAlDaet 40 
                 + dG+++A+D et
  EFC38215.1 397 WsDGSIRAVDCET 409
                 369******9665 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 2.7
       PQQ_3   1 GevlWsv 7  
                 Ge+lW+ 
  EFC38215.1 410 GEQLWTL 416
                 8888875 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 1.6
       PQQ_3  23 lvyvgtgdGtlyAlDae 39 
                 +v+ ++ d  ++++D +
  EFC38215.1 477 HVFSSSKDREIFCYDLR 493
                 6777788********87 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 2.3
       PQQ_3  24 vyvgtgdGtlyAlDaet 40 
                 v +gt d  ++ +D +t
  EFC38215.1 565 VIFGT-DEAIHVFDVDT 580
                 44444.799*****987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (623 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 3489.48
//
Query:       EFC38216.1  [L=480]
Description: fumarase class II [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   9.9e-106  353.6   0.0   1.3e-105  353.3   0.0    1.1  1  Lyase_1      Lyase
    6.4e-22   77.7   0.0    1.6e-21   76.4   0.0    1.8  1  FumaraseC_C  Fumarase C C-terminus


Domain annotation for each model (and alignments):
>> Lyase_1  Lyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  353.3   0.0  1.5e-109  1.3e-105       1     312 []      21     353 ..      21     353 .. 0.99

  Alignments for each domain:
  == domain 1  score: 353.3 bits;  conditional E-value: 1.5e-109
                 CEEEEETCHHHHHHHHHHHHHGGGHHHHHC.......HHHHHHHHHHHTTSST....HHHHHHHHHHHHHHHCHCHHCGGHHHBSSSSSHHHHHHHHHH CS
     Lyase_1   1 grftvkadklmgiftersrenfrlseedik.......alaalkkaaakanvdl....keeaaaiikaldevleegklddqfvlkviqegsgtavnmnln 88 
                 g ++v++d+++g++t+rs+enf++++e+++       ala+lk a+ak+n+++     ++a+ i+k+++e+++e k d qf+lk +q+gsgt++nmn+n
  EFC38216.1  21 GAIEVPSDAYWGAQTQRSIENFKIGGERERmpieiiyALALLKGACAKVNAEYgdldGKIAELIQKVVSEIVNEKKFDSQFPLKIYQTGSGTQTNMNVN 119
                 6799****************************************************99***************************************** PP

                 HHHH....HHTT.....HSSGIIIIITTT--HHHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHTTT-EEEEEETTEEEEEEEHHHHHHHHHHH CS
     Lyase_1  89 evig....ellg.....ekvepndkvhtgqSsnDqvpTalrlalkkalsekLlpaleqLidalkekakefkdvvkiGrThlqdAtPvtlgqelsayaea 178
                 evi+    el+g     + v+pnd+v+ gqSsnD++pTa+++a++ + +e+++p l++L++a+++k +ef+++vkiGrTh+ dAtP+t+gqe+sa++ +
  EFC38216.1 120 EVISnrciELIGgqlgsKSVHPNDHVNRGQSSNDTFPTAMHIACAIQATERVIPMLKRLREAFEKKRQEFAHIVKIGRTHTMDATPLTMGQEFSAFVSQ 218
                 *****999999999999********************************************************************************** PP

                 HHHHHHHHHHHHHHHTCEETTTTTTTSSTTTSCCTHHHHHHHHHHHHHCST.EESSSHHHHHHC-HHHHHHHHHHHHHHHHHHHHHHHHHHHTSTT.TS CS
     Lyase_1 179 lerdrerlkellkrllvellgggtavgtglnadpefaelvakelakvtglp.vkapnsfeavsdrDavvellgalkllatsLskfaeDlrllssge.ag 275
                 l+     ++++l + ++el+ ggtavgtgln++  f   v kel+ +t+lp   a+n+f a+s +Da+v l+ga +++at L+k+a+D+r+l sg+ +g
  EFC38216.1 219 LDFAVHCIEKSL-ERVYELAIGGTAVGTGLNTRECFGADVSKELSVLTSLPfKDADNKFMALSGNDALVSLSGAYNNCATLLMKIANDVRMLGSGPrCG 316
                 ************.9999********************************************************************************** PP

                 SEEEEGCCTSSC-TTSTTTEBTHHHHHHHHHHHHHHH CS
     Lyase_1 276 lvelslaesepGSSiMPgKvNPvqlElltgvagrvvG 312
                 l+el l+ +epGSSiMPgKvNP+q E++t+v+++v+G
  EFC38216.1 317 LGELILPSNEPGSSIMPGKVNPTQPEAVTMVCAQVMG 353
                 ************************************9 PP

>> FumaraseC_C  Fumarase C C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.4   0.0   1.8e-25   1.6e-21       1      53 [.     419     471 ..     419     472 .. 0.98

  Alignments for each domain:
  == domain 1  score: 76.4 bits;  conditional E-value: 1.8e-25
                  GGGGGHHHHHHHHHHHHHHHHHHHT--HHHHHHHTT-.-HHHHHHHT-HHHHH CS
  FumaraseC_C   1 LVTaLnphIGYekAakIAkeAlkegktlreavlelgllteeeldelldpekMt 53 
                  LVTaLnp+IGY++Aak+Ak+A++e+++l++a+l+l+ll+ e++d+ ++ e+M 
   EFC38216.1 419 LVTALNPIIGYDNAAKVAKKAYQENISLKQACLDLNLLSGEDFDKHVRAEDMC 471
                  8***************************************************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (480 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       546  (0.0304535); expected 358.6 (0.02)
Passed bias filter:                      505  (0.0281667); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 2812.27
//
Query:       EFC38217.1  [L=563]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-13   50.5   0.1    6.6e-12   45.5   0.0    2.7  2  UPF0020          Putative RNA methylase family UPF0020
    6.4e-09   35.8   0.0    1.5e-08   34.5   0.0    1.6  1  Methyltransf_31  Methyltransferase domain
    2.5e-07   31.3   0.0      7e-07   29.9   0.0    1.8  1  Methyltransf_25  Methyltransferase domain
    5.6e-07   30.1   0.0    1.4e-06   28.8   0.0    1.7  1  Methyltransf_11  Methyltransferase domain
    1.6e-05   24.3   0.0    2.7e-05   23.6   0.0    1.2  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
     0.0017   17.9   0.0     0.0037   16.8   0.0    1.5  1  MTS              Methyltransferase small domain
     0.0018   17.8   0.0     0.0057   16.2   0.0    1.7  2  AviRa            RRNA methyltransferase AviRa
     0.0029   17.7   0.1      0.013   15.6   0.0    2.1  2  THUMP            THUMP domain
  ------ inclusion threshold ------
      0.077   12.8   0.0       0.17   11.7   0.0    1.6  1  Methyltransf_23  Methyltransferase domain


Domain annotation for each model (and alignments):
>> UPF0020  Putative RNA methylase family UPF0020
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.81   1.6e+03      68     123 ..     220     274 ..     202     279 .. 0.78
   2 !   45.5   0.0   3.3e-15   6.6e-12      31     192 ..     399     537 ..     390     541 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.81
                 HHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS--- CS
     UPF0020  68 eaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevd 123
                  ++++++   kly+  ++++ +    +N +++gv ++ ++ + d +++  + +e++
  EFC38217.1 220 AWKQSFELFEKLYCKKFEKQNLYSKDTNFRATGVRKQTSILKHDYKSMD-MAAEYG 274
                 4556666666799999999999999999999999999999999999888.555655 PP

  == domain 2  score: 45.5 bits;  conditional E-value: 3.3e-15
                 -EEETT-TTSHHHHHHHHHHTT--TTTT----SSHHHHHHHHHHHH--EEEEES-HHHHHHHHHHHHHTT-GGGEEEEE--GGG--STTS---EEEE-- CS
     UPF0020  31 pllDPmCGsGtilIEaallganiapgllrefvlelkaeaeeearaelklygsDldrrvvqgareNaekagvgdliefsqadaakLrlkegevdvivtnp 129
                 +++DP+ GsGt+ +    l ++                      ++++ly +D++   v + ++N +k   +  i++ + d + L+ +++++dv+++++
  EFC38217.1 399 TFVDPFAGSGTLSLSLNYLFTDND--------------------PKVQLYNIDFNLDEVSAMKDNCSK---NRNIHILNCDSRFLPFRNESIDVVISDM 474
                 799*********987777777766....................5788**************999665...6788888889999998899********* PP

                 --------HHHHHHHHHHHHHHHHHH-TT..-EEEEEESSHHHHHCC---ESEEEEEEETTEE CS
     UPF0020 130 PYGerlgskkalekLYseflrelkrvlrgggrlvlltsenkalekaleeralrkvkeknvklg 192
                 P+G   g++ ++ k Y+++ ++l+r+++ +g  +llt e   le+ l+ r+   ++ ++v lg
  EFC38217.1 475 PFGVLCGNHSRNSKVYPKIVKQLERIVKPDGVVLLLTIELALLESQLNARNRWTFTTQKVTLG 537
                 ***********************************************9997767777776665 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   0.0   7.7e-12   1.5e-08       4     123 ..     397     522 ..     394     552 .. 0.79

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 7.7e-12
  Methyltransf_31   4 glrvlDlGCGtGeltfelae..elgp.kaevvGiDiseeaielArenaqklgldnveFeqgdieeleklledekfDlilsnevl........na 86 
                       ++++D+ +G+G+l++ l+   + ++ k ++++iD++ + ++ ++ n++  +  n++   +d   l+  +  e++D+++s+ ++          
       EFC38217.1 397 LVTFVDPFAGSGTLSLSLNYlfTDNDpKVQLYNIDFNLDEVSAMKDNCS--KNRNIHILNCDSRFLP--FRNESIDVVISDMPFgvlcgnhsRN 486
                      57889**************87633335999*****************77..55699***********..99**********6666669944444 PP

  Methyltransf_31  87 ladpdkileeiervlkpggilliedprllaelpakve 123
                       +  +ki +++er +kp+g++l+ ++  la l  ++ 
       EFC38217.1 487 SKVYPKIVKQLERIVKPDGVVLLLTIE-LALLESQLN 522
                      444579999***************999.333333333 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.9   0.0   3.5e-10     7e-07       5      97 .]     404     505 ..     400     505 .. 0.85

  Alignments for each domain:
  == domain 1  score: 29.9 bits;  conditional E-value: 3.5e-10
                      T-TTSHHHHHHHCTS....TSSEEEEEESSHHHHHHHHHHHHHTTTTEEEEESBCCGBSSSTTTEEEEEE.....EST.GGGSSHHHHHHHHHH CS
  Methyltransf_25   5 GcGtGrltlalakrl....gkakvtgvDiseemleaareraeeeglnvefvqgdaedlpfedgsfDlvvs.....sga.lhhlsdedlekalke 88 
                       +G+G+l+l l   +    +k +++ +D++ + + a++ ++++++ n++++++d + lpf ++s+D+v+s     + +  h  + + ++k++k+
       EFC38217.1 404 FAGSGTLSLSLNYLFtdndPKVQLYNIDFNLDEVSAMKDNCSKNR-NIHILNCDSRFLPFRNESIDVVISdmpfgVLCgNHSRNSKVYPKIVKQ 496
                      579999999999999875449********************7665.************************6654433323447888899***** PP

                      HHHHEEEEE CS
  Methyltransf_25  89 iarvLkpgG 97 
                      + r++kp+G
       EFC38217.1 497 LERIVKPDG 505
                      *******99 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0     7e-10   1.4e-06       6      95 ..     406     508 ..     402     509 .. 0.79

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 7e-10
                      TTSHHHHHHH....HTT...SEEEEEES-HHHHHHHHHHCCHHT-EEEETTEECCCTSS-TT-EEEEEEES...-CCC-........CCHHHHH CS
  Methyltransf_11   6 GtGrlaeala....krg...arvvgvDlskemlklakekaseeglkvefvvadaeklpfednsfDlvvsse...vlhhv........edpekal 81 
                      G+G l+  l     +      +++++D++   + + k++ s++++ + ++ +d + lpf+++s+D+v+s +   v   +        +   k++
       EFC38217.1 406 GSGTLSLSLNylftD-NdpkVQLYNIDFNLDEVSAMKDNCSKNRN-IHILNCDSRFLPFRNESIDVVISDMpfgV---LcgnhsrnsKVYPKIV 494
                      344444444422342.246799******************99995.99**********************95554...4443557777999*** PP

                      HHHHHHEEEEEEEE CS
  Methyltransf_11  82 keiaRvLkpgGllv 95 
                      k++ R++kp+G+++
       EFC38217.1 495 KQLERIVKPDGVVL 508
                      ***********986 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   0.0   1.3e-08   2.7e-05      34     158 ..     376     516 ..     371     539 .. 0.78

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 1.3e-08
                      HHHHHHHHH--S--TT.......EEEEES-TT-HHHHHHHHHHHHHH.EEEEEES-HHHHHHHHHHHHHHTSSTEEEEE--TTT-TTS-T-EEE CS
  Ubie_methyltran  34 lWkkfveklvavkrga.......kvlDvagGtgDlafklsdsvgekg.kvvvlDinenmLkvgekklkeegkinieflqanaeeLpfeddsfDv 119
                      lWk+ +++ +  +          +++D  +G+g l+++l     ++  kv++ +i+ n+ +v+  k + +   ni+ l+ ++  Lpf ++s Dv
       EFC38217.1 376 LWKTLLMENSILRDKLfqqsqlvTFVDPFAGSGTLSLSLNYLFTDNDpKVQLYNIDFNLDEVSAMKDNCSKNRNIHILNCDSRFLPFRNESIDV 469
                      5666555544433333334556699**************9987665559999999988888888888888888********************9 PP

                      EE..EES-G......GG-S-HHHHHHHHHHHEEEEEEEEEEEE---- CS
  Ubie_methyltran 120 vt..vsfGl......rnvtDklkaLkeayrvlkpGGrlvvlefskve 158
                      v   + fG+      rn   ++k +k++ r++kp G ++ l +    
       EFC38217.1 470 VIsdMPFGVlcgnhsRNSKVYPKIVKQLERIVKPDGVVLLLTIELAL 516
                      8533789987887889*********************9988665444 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   1.9e-06    0.0037      34     139 ..     399     511 ..     381     530 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.9e-06
                 EEEEET-TTSHHHHHHH....HHTTC.EEEEEESBHHHHHHHHHHHHHTTGCEEEEE-ST.TTTSTTS-EEEEEE---STT...TCHCHHHHHHHHHHH CS
         MTS  34 kvlDlGcGaGvlgaala....kespeaevtlvdvdarAlesakenleanklevevvasdv.leeveekkfdlivsNPPfha...gkatelavaeeliae 124
                 + +D  +G G l+++l     ++ p++++  +d +   + + k n+++n+ +++++++d  +  + ++++d+++s  Pf     ++  + +v  +++++
  EFC38217.1 399 TFVDPFAGSGTLSLSLNylftDNDPKVQLYNIDFNLDEVSAMKDNCSKNR-NIHILNCDSrFLPFRNESIDVVISDMPFGVlcgNHSRNSKVYPKIVKQ 496
                 5788889****99998622225678899999999***************9.5788777752567889************75332567788999****** PP

                 HHHHEEEEEEEEEEE CS
         MTS 125 AkeaLkegGeLliVa 139
                  +++ k++G  l+ +
  EFC38217.1 497 LERIVKPDGVVLLLT 511
                 *********987765 PP

>> AviRa  RRNA methyltransferase AviRa
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.55   1.1e+03      52      98 ..     395     443 ..     385     454 .. 0.76
   2 !   16.2   0.0   2.8e-06    0.0057     138     212 ..     439     511 ..     433     527 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.55
       AviRa  52 gapltlyDpCCGgayLltvlgllhgkk..ikkvlasDvdeevlelakkN 98 
                 ++ +t  Dp  G++ L   l +l +++    +++  D++ + ++  k+N
  EFC38217.1 395 SQLVTFVDPFAGSGTLSLSLNYLFTDNdpKVQLYNIDFNLDEVSAMKDN 443
                 4568999*********999999988762234567778777777777666 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 2.8e-06
       AviRa 138 ellakkgeekeievfkaditekeeeaekevdivitDlPYGelvswqgeseepvkqlleslaavldpeesvvavia 212
                 ++ ++++++ +i++ + d     +  ++++d+vi D+P+G l   ++ +++  ++++++l+++++  ++vv + +
  EFC38217.1 439 AMKDNCSKNRNIHILNCDSR-FLPFRNESIDVVISDMPFGVLCGNHSRNSKVYPKIVKQLERIVK-PDGVVLLLT 511
                 55555666666666666655.44555667***********************************5.577776654 PP

>> THUMP  THUMP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.4   2.8e+03      57      86 ..     104     133 ..      71     134 .. 0.77
   2 !   15.6   0.0   6.4e-06     0.013      95     142 ..     261     309 ..     234     311 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.4
                 EEEEESSHHHHHHHHHHHHHHHHHHCT-EE CS
       THUMP  57 cevceadledileaakeivkkkfeeeketF 86 
                 + + ++ ++++++++ +  k+  e  k tF
  EFC38217.1 104 TTIAGKFMKKVENSVPNELKTLSESHKVTF 133
                 467788888888888888888887776666 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 6.4e-06
                 STSSSHHHHHHHHHHHHHHCCTT..-EE-SSS-SEEEEEEEETTEEEEEE CS
       THUMP  95 khfeftsreinrevGkaivektg..lkVdlenPdivvrveiikdkayisi 142
                 kh ++ s++++ e G  i e +    kV+l+++d+ ++++++ d+++i++
  EFC38217.1 261 KH-DYKSMDMAAEYGYGIGETICkdMKVNLKKYDLDILIYLDIDRVFIGM 309
                 56.999999999977777766666677*********************97 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   8.7e-05      0.17      61     133 ..     441     527 ..     369     539 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 8.7e-05
  Methyltransf_23  61 e....kakkaqkdqfdeqeaaepqgkfdlIvlre...vlehvp..d...ppellrqiatllkpgGylllseplasl..kedrllldw 133
                      +    k ++ +  + d+ + ++ ++++d++++ +   vl+  +  +   +p+ ++q+ +++kp+G++ll+++   l  +++++   w
       EFC38217.1 441 KdncsKNRNIHILNCDSRFLPFRNESIDVVISDMpfgVLCGNHsrNskvYPKIVKQLERIVKPDGVVLLLTIELALleSQLNARNRW 527
                      24444333333333334444445555555555331113332221123346899******************8555433233333334 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (563 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       535  (0.0298399); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 3139.37
//
Query:       EFC38218.1  [L=667]
Description: hypothetical protein NAEGRDRAFT_83309 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   8.8e-250  830.0  15.7     1e-249  829.8  15.7    1.0  1  HSP70           Hsp70 protein
    3.1e-18   65.7   0.5    6.6e-15   54.8   0.1    2.3  2  MreB_Mbl        MreB/Mbl protein
     0.0011   18.7   0.0     0.0081   15.9   0.0    2.4  3  FGGY_C          FGGY family of carbohydrate kinases, C-termin
     0.0079   15.5   0.5       0.23   10.7   0.0    2.6  2  Hydantoinase_A  Hydantoinase/oxoprolinase
  ------ inclusion threshold ------
      0.033   14.6   4.1        0.8   10.2   0.4    3.2  3  FtsA            Cell division protein FtsA
        0.6   10.0  12.4       0.22   11.4   2.7    2.6  2  DUF4268         Domain of unknown function (DUF4268)


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  829.8  15.7  3.4e-253    1e-249       1     599 []      39     645 ..      39     645 .. 0.98

  Alignments for each domain:
  == domain 1  score: 829.8 bits;  conditional E-value: 3.4e-253
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXTT.SEEETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHHHTTXSSEEEEETTSBEE CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrttPsvvaFtkk.erlvGeaAkrqavtnpkntvfsvKrliGrkfsdpevqkeikelpykvvkkengkav 98 
                 +iGiDLGtt+s+va+ ++gk+e+i+n++gnr+tPsvvaF+++ erl+GeaAk+qa+ np+ntv+++KrliGrkfsd evqk+   lpyk+v k ngk++
  EFC38218.1  39 IIGIDLGTTYSCVAIYKNGKAEIIVNDQGNRITPSVVAFSEDgERLIGEAAKNQATINPTNTVYDAKRLIGRKFSDVEVQKDAALLPYKIVDK-NGKPY 136
                 69*****************************************************************************************99.***** PP

                 EEEEETTE..EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSSSCEEEEEEEEXS CS
       HSP70  99 veveaage..kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkdkernvlvyDlGg 195
                 ++ve+age   f+pe+isamvL+k+k++ae+ylg+kv+ avitvPaYfndaqRqat+dAg+iAGL v Ri+NepTAaa+aYGldk++k+ nvlv+DlGg
  EFC38218.1 137 IQVEIAGEkkIFAPEEISAMVLQKMKAIAETYLGQKVSRAVITVPAYFNDAQRQATRDAGTIAGLSVERIINEPTAAAIAYGLDKNKKDVNVLVFDLGG 235
                 ******99888**************************************************************************************** PP

                 SXEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSX...XGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTEEEEE CS
       HSP70 196 gtfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegi...dlskdkkalqrlkeaaekaKkeLSsskqteinleietvdedgkdlse 291
                 gtfdvS+l+l++G fev+aT+gDthlGGedfD+++v+++++efk+k+      ++kdkka+q+ k++aekaK+ LSs  q+e+++eie++++ g d+s+
  EFC38218.1 236 GTFDVSLLNLDEGLFEVLATNGDTHLGGEDFDHRVVRFFLDEFKRKNPKvaaSVEKDKKAIQKFKREAEKAKRVLSS--QHEARVEIESLHD-GIDFST 331
                 ********************************************99743244899**********************..9**********99.****** PP

                 EEEHHHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTT.CHHBSSSHTTTHHHHHHHHHHHHHCTCGCSHCCEEEEB CS
       HSP70 292 klsRakfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfg.kepsktvnpDeavaiGAAvqagvlsgeeevkdllllDv 389
                 kl+Rakfe+l++dl+ +tl+pve++l+d+kl+ke+++e+vlvGGstRiPkvq+l+ ++f+ k+p++++npDeava GAA+qag+l g e  +d++l D+
  EFC38218.1 332 KLTRAKFEQLNNDLFVKTLKPVEQVLRDSKLSKEDVQEIVLVGGSTRIPKVQQLLVDFFNgKKPKQGINPDEAVAAGAAIQAGILGG-ELDEDIVLVDI 429
                 ***********************************************************99**************************.7789******* PP

                 ESS-EEEEETTTEEEEEESTTCBSSEEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEEEEETTT CS
       HSP70 390 tpLslgietlggvmtkliernttiptkksqvfstaadnqtaveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvsakdket 488
                  +Lslgiet ggvmtkli+r t ipt+ksq+fst++dnq+ v i+v+qger+++kdn+llg+fel+gippaprGvpqieVtf++da+Gil+vsakd + 
  EFC38218.1 430 ASLSLGIETVGGVMTKLIPRGTKIPTQKSQIFSTYQDNQPGVLIQVYQGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFSVDADGILHVSAKDSKA 528
                 *************************************************************************************************** PP

                 CCEEEEEEECCSS.SBHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..GGGSTHHHH....HHHHHHHHHHHCHTTSSCHHHHH CS
       HSP70 489 gkeeeitieaseg.lseeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleee..aekvseaek....ekvesaieeLkeeleeeekeeie 580
                 ++e++iti++++  +++++ie+mv++a +++eedkk+ke+i+a+n +e ++y+l+++l++e  ++k+++++k    e+ +++i++L+++ +++ kee+e
  EFC38218.1 529 NVENSITITNDKLnMDKDDIERMVNEAAKFEEEDKKQKERIDARNALEGYAYQLKNQLDDEkfKDKLPAEDKkvieEETKKSISWLEQH-QDATKEEFE 626
                 ***********9989********************************************99999*****9997777777888999*999.7999***** PP

                 HHHHHHHHHHHHHHHHHHH CS
       HSP70 581 akteelkkvvekiaeklye 599
                 +++++l++++++i++k y+
  EFC38218.1 627 EERKRLEEQIKPIMTKFYQ 645
                 **************99986 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0    0.0002      0.58       4      48 ..      40      91 ..      38     116 .. 0.73
   2 !   54.8   0.1   2.2e-18   6.6e-15      76     316 ..     155     410 ..     147     415 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0002
                EEEEE-SSEEEE..EETTTE.EEEEE......ES-EEEETTT--EEEESHHHHT CS
    MreB_Mbl  4 lgiDLGtantlv..yvkgkg.ivlne......psvvAikkktkkvlavGeeAkk 48
                +giDLGt+   v  y +gk  i++n+      psvvA++++ +++  +Ge Ak+
  EFC38218.1 40 IGIDLGTTYSCVaiYKNGKAeIIVNDqgnritPSVVAFSEDGERL--IGEAAKN 91
                8******98766448888754666643444458999988887776..4666654 PP

  == domain 2  score: 54.8 bits;  conditional E-value: 2.2e-18
                 HHHHHHHHHHHTSS-S.S--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--TTSSS-E.EEEEE-SS-EEEEEEETTE.....E CS
    MreB_Mbl  76 ellkyfikkvkkkksl.skprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglpveepsgn.mvvdiGggttevavislgg.....i 167
                 +++ + +k ++++    + +r vi+vP   ++ +r+A ++a + aG +   +i+ep aAAi  gl+ ++   n +v d+Gggt +v+++ l +     +
  EFC38218.1 155 AMVLQKMKAIAETYLGqKVSRAVITVPAYFNDAQRQATRDAGTIAGLSVERIINEPTAAAIAYGLDKNKKDVNvLVFDLGGGTFDVSLLNLDEglfevL 253
                 455555555555433326789*********************************************99887763688*************975333324 PP

                 EEEEEES-SHHHHHHHHHHHHHHHHSEE--HHHH..HHHHHHH-BSS--HHHH........EEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHH CS
    MreB_Mbl 168 vtsksvrvaGdeldeaiikyirkkynlliGerta..ekikieigsavkeeeee........kmeikGrdlvtglpkevevsseevrealkepvsaivea 256
                  t    +++G+++d+ ++++   +++   ++  a  ek k++i + + e+e+         + +++   l  g+  +++++ ++ ++  ++ + + ++ 
  EFC38218.1 254 ATNGDTHLGGEDFDHRVVRFFLDEFKRKNPKVAAsvEKDKKAIQKFKREAEKAkrvlssqhEARVEIESLHDGIDFSTKLTRAKFEQLNNDLFVKTLKP 352
                 5667899**************99998877765432277777777766655543334444457788889999**************************** PP

                 HHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS.-EEE-SSTTTHHHHHHH CS
    MreB_Mbl 257 vkevLektppeLaadivdrgivltGGgallkgldkllseetgl.pvkvaedpltcvakGtg 316
                 v++vL++    L+++ v+  ivl+GG++ +  +++ll + ++  + k + +p ++va G++
  EFC38218.1 353 VEQVLRDS--KLSKEDVQ-EIVLVGGSTRIPKVQQLLVDFFNGkKPKQGINPDEAVAAGAA 410
                 *****986..57776554.49999**************99865156788899999999986 PP

>> FGGY_C  FGGY family of carbohydrate kinases, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       3.1   9.4e+03      95     119 ..      23      47 ..      17      52 .. 0.82
   2 !   15.9   0.0   2.7e-06    0.0081     145     196 ..     344     415 ..     304     416 .. 0.81
   3 ?   -1.3   0.0      0.52   1.6e+03     123     140 ..     570     587 ..     555     596 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 3.1
      FGGY_C  95 fsglrapywdpdargtitglssstt 119
                 fs + a+  d+++ g i+g++ +tt
  EFC38218.1  23 FSEENATKTDKKSGGPIIGIDLGTT 47 
                 6889999999999999999999887 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 2.7e-06
      FGGY_C 145 d..................sgkpldrlavdGGgskndllmqllAdilg..vpVerpktaeatalGaAilAav 196
                 d                  s+ ++++++++GG ++ + ++qll d ++  +p +   ++ea+a GaAi A++
  EFC38218.1 344 DlfvktlkpveqvlrdsklSKEDVQEIVLVGGSTRIPKVQQLLVDFFNgkKPKQGINPDEAVAAGAAIQAGI 415
                 45555555555566656668899*************************9999888999***********985 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.52
      FGGY_C 123 iarAaleavalqlraile 140
                  ar ale+ a+ql++ l+
  EFC38218.1 570 DARNALEGYAYQLKNQLD 587
                 5899*********99876 PP

>> Hydantoinase_A  Hydantoinase/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.1     0.032        97      77     105 ..      35      63 ..      19      74 .. 0.81
   2 !   10.7   0.0   7.7e-05      0.23      50      97 ..     198     244 ..     154     260 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.032
  Hydantoinase_A  77 gekkvItfDmGGTstDvslikdgevevsl 105
                        ++I++D+G T   v+ +k+g+ e+  
      EFC38218.1  35 SGGPIIGIDLGTTYSCVAIYKNGKAEIIV 63 
                     33489*******************99865 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 7.7e-05
  Hydantoinase_A  50 arkkpvetilSGPaaGvvgaaatsklagekkvItfDmGGTstDvslik 97 
                     + +  ve i+  P a ++++    k++++ +v++fD+GG ++Dvsl++
      EFC38218.1 198 IAGLSVERIINEPTAAAIAYGL-DKNKKDVNVLVFDLGGGTFDVSLLN 244
                     5566677888889888888887.7888888***************987 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.4   0.00027       0.8       1      36 [.      40      73 ..      40     216 .. 0.73
   2 ?    4.5   0.1     0.016        47      36      89 ..     269     393 ..     229     413 .. 0.56
   3 ?   -2.3   0.0       2.1   6.2e+03      37      41 ..     548     552 ..     474     624 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00027
                EEEEE-SSSEEEEEEETTEEEEEEEES-.-HHHHHHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxx RF
        FtsA  1 alvDiGagktdvavaedgalvhlrvigv.ggngitkd 36
                +++D+G++ ++va++++g   + ++i   +gn it +
  EFC38218.1 40 IGIDLGTTYSCVAIYKNG---KAEIIVNdQGNRITPS 73
                58***************9...5555544577777766 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.016
                 H......................HHHHHT--HHHHHHHHHHH--S--...........EEEEEHHHHH............................... CS
                 x......................xxxxxxxxxxxxxxxxxxxxxxxx...........xxxxxxxxxx............................... RF
        FtsA  36 d......................iakalrtaveeAerikikyGsala...........ekeigrkels............................... 70 
                                         +ka+++   eAe+ k     +l+                    +                               
  EFC38218.1 269 RvvrffldefkrknpkvaasvekDKKAIQKFKREAEKAK----RVLSsqhearveiesL--------Hdgidfstkltrakfeqlnndlfvktlkpveq 355
                 355555555555555544444443456666677777777....3333223233333330........25566666666666667777777777777777 PP

                 ...................GGGGSTTHHHHHHHHHT-. CS
                 ...................xxxxxxxxxxxxxxxxxxx RF
        FtsA  71 ...................ggsalpnleelaeralspk 89 
                                    g++ +p++++l+ + ++ k
  EFC38218.1 356 vlrdsklskedvqeivlvgGSTRIPKVQQLLVDFFNGK 393
                 77777777888889999999999999999999998443 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 2.1
                 HHHHH CS
                 xxxxx RF
        FtsA  37 iakal 41 
                 i++++
  EFC38218.1 548 IERMV 552
                 22222 PP

>> DUF4268  Domain of unknown function (DUF4268)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   2.7   7.5e-05      0.22      42     124 ..     509     594 ..     500     597 .. 0.74
   2 ?    2.4   4.6     0.045   1.3e+02      61      99 ..     584     624 ..     581     643 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 7.5e-05
     DUF4268  42 lklvaskkka.rvelyIskkdeeenke.ifekLkeqkeeieeelgeeleWerleekkasrisriyvlke.dvdikdkedwpeiisw 124
                 ++++++ +++ +v+   sk++ e++   + +kL  +k++ie++++e+ ++e+ ++k++ ri +   l++   ++k++ d +++ + 
  EFC38218.1 509 VTFSVDADGIlHVSAKDSKANVENSITiTNDKLNMDKDDIERMVNEAAKFEEEDKKQKERIDARNALEGyAYQLKNQLDDEKFKDK 594
                 55555544444555555555555544404689*********************9*******9988888888889998888887765 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.045
     DUF4268  61 deeenkeifekL.keqkeeieeelgeeleW.erleekkasr 99 
                 ++ +++++ +kL  e+k+ ieee +++++W e++++ ++ +
  EFC38218.1 584 NQLDDEKFKDKLpAEDKKVIEEETKKSISWlEQHQDATKEE 624
                 5667777777774578**************75555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (667 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2144  (0.119583); expected 358.6 (0.02)
Passed bias filter:                      796  (0.0443973); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.76u 0.30s 00:00:01.06 Elapsed: 00:00:00.49
# Mc/sec: 4088.87
//
Query:       EFC38219.1  [L=539]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-29  103.5   0.3    1.4e-29  103.5   0.3    2.3  3  Peptidase_C48   Ulp1 protease family, C-terminal catalytic do
  ------ inclusion threshold ------
      0.074   13.6   6.3        3.5    8.3   1.6    2.6  2  ATP-cone        ATP cone domain


Domain annotation for each model (and alignments):
>> Peptidase_C48  Ulp1 protease family, C-terminal catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.7      0.31   2.8e+03      53      85 ..     177     205 ..     122     207 .. 0.57
   2 !  103.5   0.3   1.6e-33   1.4e-29       1     187 [.     249     431 ..     249     462 .. 0.85
   3 ?   -2.1   0.1      0.32   2.8e+03     126     168 ..     481     523 ..     472     533 .. 0.54

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.31
                    S.......T.CHCHHHCTTCCCCCS..-GGG-SE CS
  Peptidase_C48  53 kkkfkeskk.kdlyngvrrwtrkvnkedlfdkdi 85 
                    +     +kk k+ + ++++   ++++ed+ d+di
     EFC38219.1 177 P-----TKKiKKVVEKTKQELSSSDSEDISDTDI 205
                    1.....2223444555555555555555555555 PP

  == domain 2  score: 103.5 bits;  conditional E-value: 1.6e-33
                    ---BHHHHHHHHHHHHHHHHH..CCCTCCCEEE--THHHHHHC..........SS.......TCHCHHHCTTCCCCCS..-GGG-SEEEEEEEC.T CS
  Peptidase_C48   1 ewlndtvidfylkllaerles..seskaervhflntffvskLtkavkdfkknkskkkfkeskkkdlyngvrrwtrkvnkedlfdkdiiyiPinedg 94 
                    e+lnd +idfyl+++ e+ +   + + +++ +++nt f+++L+                    kd  ++ +r  ++v   +lf+k+ i+iP+ne +
     EFC38219.1 249 EFLNDNIIDFYLRYIEEQFHGakARQVKNDFYIFNTHFYQLLK--------------------KDSSRAAERIAKNV---TLFEKKLIFIPVNE-N 320
                    68**************999999999******************....................66667888899999...**************.* PP

                    TEEEEEEEETCCC...................EEEEE-TTS-SSH.HHHHHHHHHHHHHHHHHCCCCCSTT-.....GGGEEEEEEE-----SSCC CS
  Peptidase_C48  95 kHWvlliinlpdk...................tililDSlislhtvkkenrpinnlkpyLleealkkkqkql....dltpfeierltkvpqqknsg 167
                    +HW+l++i++p++                      + DSl++  +      + ++++++L+++++  + ++        +f +  + ++p+q+n +
     EFC38219.1 321 VHWSLIVICNPNGtsvkkekldltkkypadarMLMYCDSLGGAIP----TNTTKRVREFLAKRYSFENPNEKpvtfTADNFPVGKA-NLPKQDNHV 411
                    *******************************989999*****999....8999*********965544333335885555555555.77******* PP

                    CHHHHHHHHHHHHHCTHHCH CS
  Peptidase_C48 168 DCGiyvlkfiellaegapqe 187
                    DCG++++++i+lla+++ ++
     EFC38219.1 412 DCGVFMIHYIQLLACTKIEN 431
                    ***************99887 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.32
                    HHHHHHHHHHHHHCCCCCSTT-.GGGEEEEEEE-----SSCCC CS
  Peptidase_C48 126 rpinnlkpyLleealkkkqkqldltpfeierltkvpqqknsgD 168
                    ++i +l    ++ea++ + ++++ ++ e +  ++v   ++++D
     EFC38219.1 481 MAISQLEDSVMKEASAHNEESPNTEKLESDGEKEVKTKETTQD 523
                    5555555566666666555555555554444444444444433 PP

>> ATP-cone  ATP cone domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   1.6   0.00039       3.5      22      64 ..     145     188 ..     116     212 .. 0.82
   2 ?    7.1   0.2   0.00089       7.9      14      70 ..     448     499 ..     444     509 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00039
                 HHHHHHH.-HHHHHHHHHHHHHHHHHHHIIT-BHHHHHHHHHHH CS
    ATP-cone  22 iekAceg.seeeideiaeeveaevrkrlrdgisteeIqdlvekt 64 
                 ie   ++ +++ ++e  +++e++v ++ +++++t++I ++vekt
  EFC38219.1 145 IETISHKkDLKSLKEKKRKIEEKVTDNSPEKPPTKKIKKVVEKT 188
                 555555558888999999************************98 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.00089
                 -HHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHHHIIT-BHHHHHHHHHHHHHHSS- CS
    ATP-cone  14 dvekIkraiekAcegseeeideiaeeveaevrkrlrdgisteeIqdlvektliehpd 70 
                 ++e Ikr ie+ + + + +      +v +   ++ ++ + ++++ d v+k++ +h++
  EFC38219.1 448 KRESIKREIEFELLQ-NPQPT----QVDQSFNSQSDSVMAISQLEDSVMKEASAHNE 499
                 678899999999777.33333....6666669999999**************97765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (539 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2063  (0.115065); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 3082.31
//
Query:       EFC38220.1  [L=304]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00033   20.5   0.1      0.017   15.1   0.0    2.9  3  NHL       NHL repeat
  ------ inclusion threshold ------
       0.11   11.6   0.1        0.2   10.7   0.0    1.4  2  LuxC      Acyl-CoA reductase (LuxC)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.1     1e+04       5      21 ..     150     165 ..     148     167 .. 0.67
   2 !   15.1   0.0   1.9e-06     0.017      12      27 ..     242     257 ..     241     258 .. 0.92
   3 ?    2.1   0.0     0.026   2.4e+02       9      28 .]     283     303 ..     280     303 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.1
                 EEEEEETTTEEEEEECC CS
         NHL   5 hGvavdsnGdiyVaDse 21 
                 +G+ ++ +++++  D++
  EFC38220.1 150 WGLDLM-GNQVFFLDYN 165
                 788887.7777666665 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 1.9e-06
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 +G +y +D+enhr++v
  EFC38220.1 242 SGLVYLSDTENHRIFV 257
                 699***********98 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.026
                 EE.TTTEEEEEECCCTEEEEE CS
         NHL   9 vd.snGdiyVaDsenhrvqvF 28 
                 vd  +G +yV ++++  + +F
  EFC38220.1 283 VDkRTGLLYVINNKSKEISIF 303
                 77789********99999998 PP

>> LuxC  Acyl-CoA reductase (LuxC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   2.2e-05       0.2     129     182 ..      25      75 ..      10     104 .. 0.77
   2 ?   -3.5   0.0      0.46   4.1e+03     279     318 ..     206     241 ..     202     260 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 2.2e-05
        LuxC 129 flaaallksladvdenhtladslsvvyfksgdtkleeeivqnaDvvvawGgeea 182
                 +l+  l+ ++++ + n++l+++l v +f+ +       i++++Dv+++ Gg++ 
  EFC38220.1  25 YLKQSLASKFLQFSLNFKLVRTLNVANFEPS---FDIAISNCFDVIIVVGGSSL 75 
                 56778999******************99543...344577899********864 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 0.46
        LuxC 279 deaakisskraelklkylladekkvvsskdqkwtvllsee 318
                 +++ +i +k+++      +++ + v+ + ++++++ +++e
  EFC38220.1 206 QQSLEIFKKQEN----NWISKRRVVIPKCSTAYSIFYEKE 241
                 555555555555....566666666667777777776666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       617  (0.0344135); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1816.14
//
Query:       EFC38221.1  [L=233]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (233 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       635  (0.0354175); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.24s 00:00:00.69 Elapsed: 00:00:00.41
# Mc/sec: 1686.66
//
Query:       EFC38222.1  [L=585]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.7e-65  220.5  31.1    4.7e-44  151.3   0.3    4.5  4  DUF4246         Protein of unknown function (DUF4246)
  ------ inclusion threshold ------
       0.11   12.9   0.0       0.44   11.0   0.0    2.1  1  2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
       0.28   10.1   9.7      0.011   14.7   3.1    1.9  2  DUF2722         Protein of unknown function (DUF2722)
       0.51   10.5   1.7       0.72   10.0   0.6    1.8  2  DUF1993         Domain of unknown function (DUF1993)
       0.88    8.8  24.1      0.028   13.8  15.0    2.1  2  BUD22           BUD22
        5.1    6.4  12.7       0.13   11.7   5.4    1.9  2  SelP_N          Selenoprotein P, N terminal region


Domain annotation for each model (and alignments):
>> DUF4246  Protein of unknown function (DUF4246)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.5   6.4e-07    0.0019      10      49 ..      54      89 ..      45     111 .. 0.81
   2 ?   -8.9  12.0         6   1.8e+04     220     261 ..     139     189 ..     116     223 .. 0.38
   3 !   71.7   1.2   2.2e-23   6.5e-20      82     221 ..     242     365 ..     228     369 .. 0.85
   4 !  151.3   0.3   1.6e-47   4.7e-44     294     449 ..     369     521 ..     362     525 .. 0.92

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 6.4e-07
     DUF4246 10 klmeaitdkpdWekkvfdeeivakWkkealaaeeeellse 49
                k++ +i dk++W++k+  ++ivakW+ke++++     +se
  EFC38222.1 54 KIVRQILDKDNWQEKIIFNTIVAKWRKETISQG----ISE 89
                7899************************87665....444 PP

  == domain 2  score: -8.9 bits;  conditional E-value: 6
     DUF4246 220 vlaklkeeereprrieeeepeeeeeeeeede...................eeeeereeewe 261
                 +l +           +eeepe+++++ +e+e                   ee e++e+e +
  EFC38222.1 139 TLFES----------TEEEPEKKKKKVQEEEkkkaegnadqkikkkldenEEDEDNEDEMN 189
                 22221..........1111211111111111111122122222222222211111111222 PP

  == domain 3  score: 71.7 bits;  conditional E-value: 2.2e-23
     DUF4246  82 vksDtlvseelkeeLkkavakL.edvpeeekdwhpgsdeqvldlVhpslfplvYgrtrvlkdgvvkledalesagkGevlekkllskkfqwLPcevefs 179
                 ++ ++l++++l+e+Lkk+++++ e++p ++ dwhpgs++qvld++hpsl++   + +    ++            kGev        + qw+P++++++
  EFC38222.1 242 LEKENLIPADLTERLKKQLNEIvENTPVDKLDWHPGSNQQVLDIIHPSLYCYSKELSVLN-EK------------KGEVR---VGVAETQWIPTDFKVD 324
                 466899*************998799*************************9765555433.32............45543...345678********** PP

     DUF4246 180 edgksvkitSYINnLhpkkhkelYsviekliekaiplwnevl 221
                 +d+k v+  SYINn++p  +k+l ++i ++++++i++ n+ +
  EFC38222.1 325 SDNK-VTPLSYINNVNPITQKDLQDTICEVLSHFIEPVNNFV 365
                 9998.*******************************999865 PP

  == domain 4  score: 151.3 bits;  conditional E-value: 1.6e-47
     DUF4246 294 kgLqVivklanieLtPekpeyeggswhveGqlnEhIvAtalyyydseNitesrLsFrqkvdeeeakeeleyeqddhealeevfgien.esslqelGsve 391
                 +++qVivk an+ +tPe+  y+gg+wh+eG + E+IvAt+++yy+++Ni++s L+Frq+++ee+      +eqd+     e fgi++ ++ +  +G+v+
  EFC38222.1 369 DKVQVIVKAANVIVTPEQGFYPGGTWHTEGDT-ENIVATGIFYYECQNIKQSFLEFRQSLREEN---FYYIEQDNVLQAWERFGIHDgDKLCEVIGKVK 463
                 789***************************86.99***********************988854...357888888888899*****44669******* PP

     DUF4246 392 tkegrllaFpNvlqhrvepfeLaDktkpGhrkilaLfLVDPhiriistanVppQqkdw 449
                 t+eg++++FpN+ qhrv++f  +D++k   rkil++f VDP+ +iist+++  Q++d 
  EFC38222.1 464 TTEGKCIIFPNTNQHRVKHFFPEDPKKTATRKILVFFFVDPDAPIISTSHIDNQRRDV 521
                 ********************************************************96 PP

>> 2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00015      0.44      59      91 ..     453     485 ..     395     493 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00015
  2OG-FeII_Oxy_5  59 keenqslvdvkpkeGdlvlFPswlrHevlpneg 91 
                     ++  + +  vk +eG++++FP+  +H+v+ +  
      EFC38222.1 453 DKLCEVIGKVKTTEGKCIIFPNTNQHRVKHFFP 485
                     44555667899*****************98865 PP

>> DUF2722  Protein of unknown function (DUF2722)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   3.1   3.8e-06     0.011     301     440 ..      46     209 ..      42     220 .. 0.62
   2 ?   -2.0   0.1      0.43   1.3e+03     329     412 ..     477     574 ..     471     580 .. 0.49

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 3.8e-06
     DUF2722 301 qvkpipaqplhkqsksavqpsqesmtsfqhiiqfhhwkpeeeseg..............................esssasqtkshkRrkssssfesid 369
                 qv+p  a    +q  + + + qe +  f+ i+    w+ e+ s+g                              +++ +++ + ++R++ +     id
  EFC38222.1  46 QVNPLDAEKIVRQI-LDKDNWQEKII-FNTIVA--KWRKETISQGisessflvamdilndlleistyrkrccgccNANPKKIKNWSDREEKT-----ID 135
                 77777777777774.55556665543.445555..799999999999999999999998888888888887766655555666666666555.....66 PP

     DUF2722 370 lnsas.ei..lkpaikfensaiasqekeddddddddekerkkeeekdkekdsikadddkdlsmdssineegete 440
                  n +  e    +p  k ++ ++ +++k + + d++ +k+ +++ee++ ++d++++++d+ +++d +i+e+ e+e
  EFC38222.1 136 ENETLfESteEEPEKKKKKVQEEEKKKAEGNADQKIKKKLDENEEDEDNEDEMNENEDEVIEDDDEIIEDDEEE 209
                 55543222113444444444444444444444445555555555555666777888888888887776665554 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.43
     DUF2722 329 qhiiqfhhwkpeeeseg...................esssasqtkshkRrkssssfesidlnsas.eilkpaikfensaiasqekeddddddddekerk 407
                 qh ++  h  pe++ ++                   +s+  +q    +R    s++ s    ++    +k +i+f ++   +q +e  +   d+ k + 
  EFC38222.1 477 QHRVK--HFFPEDPKKTatrkilvfffvdpdapiisTSHIDNQ----RRDVIISNSFSLAQKITYpVLVKNVIPFIPQMTEEQANETREILMDHRKYKR 569
                 55555..666666666666666666666444332112222233....3333334444444444443345666777777666666666665544444444 PP

     DUF2722 408 keeek 412
                  ++++
  EFC38222.1 570 DDKNE 574
                 44333 PP

>> DUF1993  Domain of unknown function (DUF1993)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.6   0.00024      0.72      18     120 ..      73     179 ..      70     191 .. 0.80
   2 ?   -3.4   0.0       3.1   9.1e+03      92     133 ..     542     581 ..     538     583 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00024
                 HHHHHHHCCHHHHC..HHH.HHT--SSTTS--HHHHHHHHHHHHHHHHCHH...CT-GS----S.-SSHHHHHHHHHHHHHHHHCS-GGGHCCCCCEEE CS
     DUF1993  18 alLkkaeahaaakkidpee.llearLapDMlpLsfQvqiatdtakkavarl...agkeppsledeektfadlrariaktialLesvdpekldakeekev 112
                 ++ +k +++  +++i++++ l+ + + +D l++s+  + ++   ++  +++   + +e ++++++e+ f++ ++  +k  + +++ +++k ++++++++
  EFC38222.1  73 TIVAKWRKETISQGISESSfLVAMDILNDLLEISTYRKRCCGCCNANPKKIknwSDREEKTIDENETLFESTEEEPEKKKKKVQEEEKKKAEGNADQKI 171
                 566777777788889988878899999999999988877766655555555322778999999************************************ PP

                 E.C.CCCC CS
     DUF1993 113 elklggke 120
                 + kl ++e
  EFC38222.1 172 KKKLDENE 179
                 98885544 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 3.1
                 HHHHHHCS-GGGHCCCCCEEEE.C.CCCCEEEEHHHHHHHTH CS
     DUF1993  92 tialLesvdpekldakeekevelklggkeleftgeeyllefa 133
                 +i ++ ++++e+ +  e++e+ ++ ++ + + + e+y +ef+
  EFC38222.1 542 VIPFIPQMTEEQAN--ETREILMDHRKYKRDDKNEQYEREFS 581
                 55566666666544..45666666677777777777777765 PP

>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   1.7      0.12   3.7e+02     212     241 ..      10      34 ..       2      85 .. 0.57
   2 ?   13.8  15.0   9.4e-06     0.028     140     211 ..     142     210 ..     111     245 .. 0.51

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.12
       BUD22 212 eerelaqydgllasddededeyneetdees 241
                 ee+ ++q  g  +++de+e    ee+++e+
  EFC38222.1  10 EEEPTSQISG--NEEDEEEF---EESSQEE 34 
                 2222222222..11111111...1111111 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 9.4e-06
       BUD22 140 kkkkkeeekkkkkkkkkkkkkkeeee.eeesdkeeesedsed.eekeeseddeeeeeededdedaeedeedeea 211
                 + +++e+ekkkkk ++++kkk+e ++ ++ ++k +e+e++ed e++ ++++de  e++de  ed+ee     e+
  EFC38222.1 142 ESTEEEPEKKKKKVQEEEKKKAEGNAdQKIKKKLDENEEDEDnEDEMNENEDEVIEDDDEIIEDDEE-----EE 210
                 2345555555555444444444433334444444444444441111111111111111111111111.....11 PP

>> SelP_N  Selenoprotein P, N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.7      0.72   2.1e+03     171     196 ..      20      42 ..       2      55 .. 0.37
   2 ?   11.7   5.4   4.3e-05      0.13     143     222 ..     106     187 ..      93     199 .. 0.51

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.72
      SelP_N 171 aeekpaeaeektehehahshkqghkh 196
                 +ee  +e    +e ++++++  +h+h
  EFC38222.1  20 NEEDEEEF---EESSQEEEEFISHRH 42 
                 11111111...111111111122222 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 4.3e-05
      SelP_N 143 atyceekCGnCslesseaeeeckevtkaaeekpaeaeektehehahsh.kqghkhhekhghhHke.keelsesqqeepeeee 222
                  ty ++ CG C+ + ++ ++ +++  k  +e+ +  e+++e+++++++  q  ++++  g+  ++ k++l e++++e++e+e
  EFC38222.1 106 STYRKRCCGCCNANPKKIKNWSDREEKTIDENETLFESTEEEPEKKKKkVQEEEKKKAEGNADQKiKKKLDENEEDEDNEDE 187
                 58***********999777766665553333322222222222222221222233333332222214444444433333222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (585 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2466  (0.137543); expected 358.6 (0.02)
Passed bias filter:                      728  (0.0406046); expected 358.6 (0.02)
Passed Vit filter:                       155  (0.00864521); expected 17.9 (0.001)
Passed Fwd filter:                        29  (0.00161749); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.96u 0.39s 00:00:01.35 Elapsed: 00:00:00.56
# Mc/sec: 3141.34
//
Query:       EFC38223.1  [L=750]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (750 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1272  (0.0709465); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.29s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 4464.22
//
Query:       EFC38224.1  [L=625]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.3e-06   26.0  11.9      9e-06   25.5   0.1    3.2  4  DUF1647   Protein of unknown function (DUF1647)


Domain annotation for each model (and alignments):
>> DUF1647  Protein of unknown function (DUF1647)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.6   0.00013       2.3      13      95 ..      51     123 ..      43     154 .. 0.69
   2 !   25.5   0.1     5e-10     9e-06      90     140 ..     159     209 ..     150     210 .. 0.94
   3 ?   -2.5   0.2      0.21   3.8e+03      55      94 ..     433     472 ..     403     492 .. 0.59
   4 ?   -3.2   0.1      0.35   6.3e+03      72      93 ..     576     597 ..     565     614 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00013
     DUF1647  13 dfCYkdpqnsssiGkkFdCslvetleklklleeeeklvdlselikneedvvFvsatsddhlkeakksiksirkyypkkklily 95 
                 d+CY   +n++  Gk  +       + l++l  +++  +++   +++ +   v+a+s+ +++++++ + si++ y +k  + +
  EFC38224.1  51 DYCYYLHNNNN--GKSLSM-----KQVLEIL--TRNTASMKYPLQQHGNPYIVTAVSSGYFERFENFVGSIHRIYETKEKL-F 123
                 55665554443..444332.....2333333..45667788888999999***********************99876643.3 PP

  == domain 2  score: 25.5 bits;  conditional E-value: 5e-10
     DUF1647  90 kklilysldlseeeieklkkdknlevrkFntskYPeyvknlkeyrfkalil 140
                 + +i+y+l++++e++++ k++kn+ev   +++  P++ +nlk++ +k+l++
  EFC38224.1 159 RPIIVYNLGMTSEQVQRAKTFKNVEVVDIDFKLLPSHFNNLKSFAWKPLVM 209
                 5689*********************************************98 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.21
     DUF1647  55 likneedvvFvsatsddhlkeakksiksirkyypkkklil 94 
                  +++++d  F s ++++  k+++   k+  ky  ++  il
  EFC38224.1 433 YMTHRKDETFESDVNQKTTKYSHCFNKISFKYTETQEAIL 472
                 3444444445555555444444444444444555555444 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 0.35
     DUF1647  72 hlkeakksiksirkyypkkkli 93 
                 h +e+++++k i+     + +i
  EFC38224.1 576 HKNENQEMYKHIKSRIIYHDFI 597
                 3344445555555544444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (625 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       927  (0.0517039); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.35s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 3733.65
//
Query:       EFC38225.1  [L=911]
Description: aconitase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   1.1e-182  608.2   0.0   1.5e-182  607.7   0.0    1.1  1  Aconitase    Aconitase family (aconitate hydratase)
    1.2e-40  138.8   0.0    3.5e-40  137.4   0.0    1.8  1  Aconitase_C  Aconitase C-terminal domain


Domain annotation for each model (and alignments):
>> Aconitase  Aconitase family (aconitate hydratase)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  607.7   0.0  1.7e-186  1.5e-182       1     461 []      64     580 ..      62     580 .. 0.94

  Alignments for each domain:
  == domain 1  score: 607.7 bits;  conditional E-value: 1.7e-186
   Aconitase   1 eki..wdahlveeegiayvpdrvllqdvtgvqalvdlaaareavrrlggtlatidhlvpvdlvidhsv.....gaeealeknledefernkeryefLks 92 
                 eki  w++  +++ +i+++p+rvl+qd+tgv+a+vdlaa r+av+rlgg++a +++lvpvdlvidhsv     g+++al++n+e+ef+rn er++fLk+
  EFC38225.1  64 EKIlnWEESSKKSIEIPFKPARVLMQDFTGVPAVVDLAAIRDAVKRLGGNPANVNPLVPVDLVIDHSVqvddfGSKDALQQNQEKEFNRNYERFKFLKW 162
                 6784455554444339*********************************************************************************** PP

   Aconitase  93 aakaf.girvvppgqGIvHqvnlEy......................glalpgktvvgtDSHTtmigglGvlaiGvGgieaeavllgqplelkipkvvg 168
                 ++kaf ++++vppg+GIvHqvnlEy                       l++p+ ++vgtDSHTtmi+glGvl++GvGgieaea++lgqp  + +p+vvg
  EFC38225.1 163 GSKAFkNLQIVPPGSGIVHQVNLEYlarvvfenneelsstdkennlqALLYPD-SLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPSAMVLPEVVG 260
                 ****************************************999887769****.********************************************* PP

   Aconitase 169 vkltGklkegvtakDlvlavigklrkkgvvgkvvEffGegvesLsledraTiaNMaaEvGAttglfpvdektleYLkatgreeaav.lveaydkaqalf 266
                 +kltGkl   +ta+Dlvl+++++lrk gvvgk+vEf+Gegv++Ls++draTi+NMa+E+GAt+g+fp+d++tl++Lk+++r+e++v lv++y kaq+lf
  EFC38225.1 261 YKLTGKLTGAATATDLVLTLTQNLRKLGVVGKFVEFYGEGVNNLSVADRATISNMAPEYGATMGFFPIDNTTLTFLKQSNRDEKKVaLVAEYLKAQKLF 359
                 *************************************************************************************99************ PP

   Aconitase 267 .elaade.daeydkvleldlstlepsvagpkrPqdavplselvkkefkeele...........keaaekaley.klkegtklkdgkvdiaaigSCTNss 351
                  + ++d+ + +y+  leldl t++ps+agpkrP+d+v+l++   kefke l+           +e+ ek++e+  ++++++l++g+v+i ai+SCTN+s
  EFC38225.1 360 vTSDSDAaNIRYSAKLELDLTTVVPSLAGPKRPHDRVSLTDVH-KEFKEGLTakrgfkgfeipAEDSEKTVEIeYQGKKYNLTHGSVVISAITSCTNTS 457
                 75555543899****************************6555.58999998999********5555555555447889******************** PP

   Aconitase 352 nedvraaaglla.kavekglkvkpgvktsvaPGSevvkayleaeGlleiLekaGfevvgagCstCignsdrle........ege...aivsssNRNFeg 438
                 n++v++aa+lla kave+gl+v+p++kts++PGS+vv++y++++Gl+ +L+k+Gf+vvg+gC+tCigns++l+        + +   a+v+s+NRNFe+
  EFC38225.1 458 NPSVMLAAALLAkKAVEQGLTVNPYIKTSLSPGSGVVSEYMTKSGLQGYLDKLGFNVVGYGCMTCIGNSGELPevvhetivNSNlvsASVLSGNRNFEA 556
                 ************************************************************************988766665333899************ PP

   Aconitase 439 Rqgpntra.yLaSPelvvaaAlaG 461
                 R++p ++a yLaSP+lvva+AlaG
  EFC38225.1 557 RVHPIVQAnYLASPPLVVAYALAG 580
                 ***********************9 PP

>> Aconitase_C  Aconitase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.4   0.0   3.8e-44   3.5e-40       2     130 ..     710     837 ..     709     838 .. 0.98

  Alignments for each domain:
  == domain 1  score: 137.4 bits;  conditional E-value: 3.8e-44
                  CCCCCCTT--CHHHHSTGGGCCGHCCHHHCCCGGTTTCCCCTTTSBBSEEEETTTTEEEEHHHHHHHHHHTT--EEEE--SSBTBS---THHHHHHHH CS
  Aconitase_C   2 ekllklkGlttedeksnvdtdlkipkqfegtianiglgnelveekrankttdlddgekedvvdaaerykkegaklvviagknfGeGSSRehAAkalrl 99 
                  +++l ++G++++d++ +++++++++++++gt+an++l n+++  k  +   ++++ge  +v+da  +y+++g +l+vi+g+++G+GSSR++AAk+++l
   EFC38225.1 710 AQYLLERGVERKDFNTYGARRGNDEVMVRGTFANVRLYNKMIG-KPGPISLHVPSGEAVSVFDASVKYREAGNELIVIGGEQYGSGSSRDWAAKGPYL 806
                  578999************************************9.9999************************************************** PP

                  TTEEEEEES-B-HHHHHHHHHTT-EEEEEST CS
  Aconitase_C 100 lGikaviaeSFerIfennliknglLplefke 130
                  lG+kavia SFerI+++nl ++g++pl+fke
   EFC38225.1 807 LGVKAVIATSFERIHRSNLAGMGIIPLQFKE 837
                  *****************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (911 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       387  (0.0215851); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.30s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 5487.10
//
Query:       EFC38226.1  [L=447]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.7e-10   39.2   0.9    1.3e-09   38.3   0.9    1.5  1  BTB       BTB/POZ domain
  ------ inclusion threshold ------
       0.08   13.1   0.1       0.24   11.6   0.1    1.8  1  Death     Death domain
      0.093   12.7   0.1       0.19   11.7   0.1    1.5  1  DMP12     DNA-mimic protein
       0.96   10.2  14.1       0.11   13.3   8.5    2.2  2  DTHCT     DTHCT (NUC029) region
        3.9    6.3   7.3        6.1    5.7   7.3    1.2  1  DUF2722   Protein of unknown function (DUF2722)


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3   0.9   3.6e-13   1.3e-09       1     107 [.     168     279 ..     168     282 .. 0.84

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 3.6e-13
                 HHHHHHHTTTS-EEEEETT.....TEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHH CS
         BTB   1 lnelresgelcDvtlvvgd.....gkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadll 94 
                 ++el ++++ +D+t++++d     + +++ahk++L+   +yFk+ f + + ++++ +      ++   ++++L+ +Yt +++ +s     ++ ++a ++
  EFC38226.1 168 FEELYKKKKDFDITIKFKDtstgkEGSLPAHKMFLSIFCNYFKKYFDKSP-KKNQIVLGSSLSITEAHVKSFLDLMYTNRCPEQSLIHFYKVAQIATIF 265
                 6789999***************98889**********************4.333333344557778899**************999999********** PP

                 T-HHHH.HHHHHHH CS
         BTB  95 qiprlk.kaceefl 107
                 ++++++  ac e+l
  EFC38226.1 266 ECDAVIfSACNEML 279
                 ***99735565555 PP

>> Death  Death domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   6.8e-05      0.24       6      56 ..     293     341 ..     289     346 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.8e-05
                 HHHCCSTCCSCCHHHHHHHT.TSHHHHHHHHHHSSSTHHHHHHHHHHHHHHH CS
       Death   6 rildhpdplgkdWkelarkL.glseeeidriekennslrsqsyalLqlWedr 56 
                  il++ ++  ++W  l+r L +  + e++++++    l+sq+ ++L +W+ +
  EFC38226.1 293 SILNSIHE-SSSWNLLFRALcERVHKEVEQLRNGG--LKSQICEILSNWKGS 341
                 57777788.89*********766677899999999..************975 PP

>> DMP12  DNA-mimic protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   5.3e-05      0.19      31      92 ..     309     370 ..     282     387 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.3e-05
                 TTEEEE-HHHHHHHHHHTHHHHHHHHHS--TTS--SEEEEE-HHHHHHHHHHHHTSTTTTSH CS
       DMP12  31 etvveitenqiieyqnrglwrlvseitdnwlfgpsegdwlidkesilavkeklqnsdfstep 92 
                  ++ e   +++ + +n gl + + ei  nw    +  +w  dke++   + kl +s +s e 
  EFC38226.1 309 RALCERVHKEVEQLRNGGLKSQICEILSNWKGSDNYIQWSEDKEALSHNHFKLSKSTYSPED 370
                 566677778888899******************************************99875 PP

>> DTHCT  DTHCT (NUC029) region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   8.5     3e-05      0.11      39      84 ..      17      65 ..       1      71 [. 0.69
   2 ?   -1.4   0.3       1.1     4e+03      39      66 ..     362     392 ..     341     413 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3e-05
       DTHCT 39 ktssssedddsdpgkktsk...atakKkkKkaseddddfsvdldseeds 84
                  ss++ed+d +p++ t+    +  +Kk+K a ed++df++d++ e+d+
  EFC38226.1 17 VLSSDDEDEDDQPQQVTKTnneEQEAKKRKIAEEDEEDFDIDSEDEDDA 65
                345666677777777776688888899***999********77755554 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.1
       DTHCT  39 ktssssedddsdpgkktsk...atakKkkKk 66 
                 ++s+ s +d++   k  +    + + K kK+
  EFC38226.1 362 SKSTYSPEDAYTMWKTLKEtvfPLSHKLKKP 392
                 3334445666666655555555555666654 PP

>> DUF2722  Protein of unknown function (DUF2722)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   7.3    0.0017       6.1     379     438 ..       7      65 ..       2      94 .. 0.62

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0017
     DUF2722 379 paikfensaiasqekeddddddddekerkkeeekdkekdsikadddkdlsmdssineege 438
                 p+i+ +++     + ++d+dd+ ++ ++ ++ee++ +k +i ++d++d ++ds+  e+  
  EFC38226.1   7 PVISQKQETLVLSSDDEDEDDQPQQVTKTNNEEQEAKKRKIAEEDEEDFDIDSED-EDDA 65 
                 55554444443333344444444444444555555677899999********997.3333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (447 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1475  (0.0822689); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.51u 0.23s 00:00:00.74 Elapsed: 00:00:00.40
# Mc/sec: 3375.61
//
Query:       EFC38227.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1453  (0.0810419); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1454.57
//
Query:       EFC38228.1  [L=704]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-20   72.1   0.5    8.2e-06   25.6   0.0    7.3  7  NHL            NHL repeat
     0.0012   19.4   0.3      0.003   18.0   0.3    1.8  1  GPS            GPCR proteolysis site, GPS, motif
      0.002   18.4   0.7     0.0053   17.0   0.7    1.7  1  Shisa          Wnt and FGF inhibitory regulator
     0.0028   17.5   0.8       0.01   15.7   0.8    2.0  1  YajC           Preprotein translocase subunit
     0.0067   16.3   3.0      0.019   14.8   3.0    1.7  1  TMEM154        TMEM154 protein family
      0.007   15.3   0.7      0.011   14.6   0.7    1.2  1  Amnionless     Amnionless
     0.0089   16.0   5.4      0.014   15.3   5.4    1.4  1  RIFIN          Rifin
     0.0097   16.8   1.3      0.063   14.2   0.4    2.3  2  EphA2_TM       Ephrin type-A receptor 2 transmembrane domain
  ------ inclusion threshold ------
      0.012   15.1   3.0      0.023   14.1   3.0    1.5  1  DUF5305        Family of unknown function (DUF5305)
      0.013   15.0   2.1      0.029   13.9   2.1    1.5  1  Stevor         Subtelomeric Variable Open Reading frame
      0.022   15.0   1.2      0.057   13.7   1.2    1.6  1  Orf78          Orf78 (ac78)
      0.037   14.0   0.6      0.075   13.0   0.6    1.5  1  Protocadherin  Protocadherin
      0.045   13.2   9.3      0.096   12.1   9.3    1.5  1  SKG6           Transmembrane alpha-helix domain
      0.047   14.0   2.5      0.084   13.2   0.2    2.5  2  Sigma_reg_N    Sigma factor regulator N-terminal
      0.065   13.3   2.8        0.2   11.7   1.1    2.7  3  DUF4577        Domain of unknown function (DUF4577)
      0.066   13.3   5.2       0.13   12.4   1.8    2.5  2  MpPF26         M penetrans paralogue family 26
       0.09   12.1   0.7       0.14   11.6   0.7    1.3  1  DAG1           Dystroglycan (Dystrophin-associated glycoprote
      0.098   12.5   0.5       0.59    9.9   0.3    2.2  2  SP_C-Propep    Surfactant protein C, N terminal propeptide
       0.97    9.5   4.4       0.46   10.6   1.4    2.1  2  DUF3278        Protein of unknown function (DUF3278)
        2.6    8.0   6.6       0.83    9.6   0.5    3.1  3  DUF4006        Family of unknown function (DUF4006)
          3    7.5   6.8       0.36   10.4   1.7    2.1  2  Baculo_11_kDa  Baculovirus 11 kDa family
        4.4    7.3   5.6        0.4   10.6   0.6    1.8  1  DUF3377        Domain of unknown function (DUF3377)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   0.0     9e-05     0.074       3      25 ..      59      81 ..      57      82 .. 0.92
   2 ?    5.0   0.0     0.034        28       1      23 [.     118     141 ..     118     146 .. 0.89
   3 ?    0.7   0.0      0.81   6.6e+02       1      11 [.     176     187 ..     176     204 .. 0.68
   4 !   25.6   0.0     1e-08   8.2e-06       1      27 [.     235     261 ..     235     262 .. 0.95
   5 !   13.6   0.0   6.6e-05     0.053      12      26 ..     303     317 ..     293     319 .. 0.83
   6 ?    3.6   0.0     0.093        76      17      25 ..     358     366 ..     355     367 .. 0.89
   7 ?   -0.9   0.0       2.5     2e+03       9      18 ..     380     389 ..     379     389 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 9e-05
                SEEEEEEETTTEEEEEECCCTEE CS
         NHL  3 yPhGvavdsnGdiyVaDsenhrv 25
                +P+Gv+v++  ++++aD++nh++
  EFC38228.1 59 WPAGVRVSNYSRVLIADTGNHQL 81
                7********************98 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.034
                 BSSEEEEEEE.TTTEEEEEECCCT CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenh 23 
                 +n+P+ ++++ + + +y+a+s+n+
  EFC38228.1 118 LNEPRQITMStTENALYIAESGNN 141
                 789999*****************8 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.81
                 BSSEEEEEEE.T CS
         NHL   1 fnyPhGvavd.s 11 
                 +n P+Gv+ d +
  EFC38228.1 176 LNGPRGVTFDtT 187
                 689999999853 PP

  == domain 4  score: 25.6 bits;  conditional E-value: 1e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n P+ va++snGdiy+aD+ n+r+++
  EFC38228.1 235 LNGPQAVAIMSNGDIYIADTQNNRIRK 261
                 799**********************97 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 6.6e-05
                 TTEEEEEECCCTEEE CS
         NHL  12 nGdiyVaDsenhrvq 26 
                 ++d+y+aDs nhr++
  EFC38228.1 303 QNDLYIADSWNHRLR 317
                 79***********97 PP

  == domain 6  score: 3.6 bits;  conditional E-value: 0.093
                 EEECCCTEE CS
         NHL  17 VaDsenhrv 25 
                 V+D++n+r+
  EFC38228.1 358 VTDTNNQRI 366
                 9*******9 PP

  == domain 7  score: -0.9 bits;  conditional E-value: 2.5
                 EETTTEEEEE CS
         NHL   9 vdsnGdiyVa 18 
                 ++snG ++V+
  EFC38228.1 380 INSNGTLCVT 389
                 79*******7 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.3   3.7e-06     0.003       2      45 .]     564     616 ..     563     616 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 3.7e-06
         GPS   2 sCvfWdeeneetgsWsteGCel............tesdnknetvCsCnHLtsFAvL 45 
                 sC+++   n+ ++ W ++G ++            t+ +   +++C+ +HLtsF v+
  EFC38228.1 564 SCAYY---NTLKNTWESSGLKTtilsflnktidnTNFQVVISVKCETSHLTSFGVI 616
                 8****...56789*******98899****987774444555789*********996 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.7   6.5e-06    0.0053      59     133 ..     627     693 ..     607     704 .] 0.66

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 6.5e-06
       Shisa  59 eslktgreekekqlgsalevpkdiyvpvlivktifivfvivgvvvivcccgclkkkqrekrpgrenlssalaevg 133
                 ++++t++  ++++++sa  v   i+++v +v+ ++i+++i+++v+++ +   l++k ++   +r++l+  l+++ 
  EFC38228.1 627 NKVQTST--YTSSDQSA--VT--IGITVGVVGVVVILLIILIIVIFTTV-LLLRSKRKNA-ENRKKLQAKLQDQL 693
                 2233322..33333333..66..99****************99999987.5556655544.46777777777663 PP

>> YajC  Preprotein translocase subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.8   1.3e-05      0.01       3      38 ..     656     692 ..     653     697 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.3e-05
        YajC   3 llplvlifvif.yfllirpqqkkqkehkemlasLkkG 38 
                 +l+++li+vif  +ll+r+++k ++++k+++a+L+  
  EFC38228.1 656 ILLIILIIVIFtTVLLLRSKRKNAENRKKLQAKLQDQ 692
                 5677888888845999*****************9865 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   3.0   2.4e-05     0.019      19      94 ..     605     682 ..     593     698 .. 0.51

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.4e-05
     TMEM154  19 eesadatsaasteseslk.qeeakeslssaelsnesdqlel.vlmiiiPlvllillllvviiliqk.kkrkrsKddeks 94 
                  e++++ts  +  + s+k +  +++ + s+ +s +++ + + + + ++  v+++l++l+++i+ ++   r ++K+ e+ 
  EFC38228.1 605 CETSHLTSFGVI-DMSVKkTLSENKVQTSTYTSSDQSAVTIgITVGVVGVVVILLIILIIVIFTTVlLLRSKRKNAENR 682
                 567777777776.666662333444455555555555555544444555555444444444444331234444444333 PP

>> Amnionless  Amnionless
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.7   1.3e-05     0.011     314     393 ..     607     685 ..     577     697 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.3e-05
  Amnionless 314 aehgealgilsaeletsgasssdssaagapgesaglvlgivfglvlllllllillllllrrkgvl.rlpqllkspsrreev 393
                  +h+ ++g+ + ++++  ++++ ++++ +++ + ++++gi +g+v ++++lli+l++++ ++++l r ++  k+  +r+++
  EFC38228.1 607 TSHLTSFGVIDMSVKKTLSENKVQTSTYTSSDQSAVTIGITVGVVGVVVILLIILIIVIFTTVLLlRSKR--KNAENRKKL 685
                 5788899999999988888877777667889999999999999977777777777777777777658877..333233333 PP

>> RIFIN  Rifin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   5.4   1.7e-05     0.014     252     318 ..     618     689 ..     434     692 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1.7e-05
       RIFIN 252 eaaaeataeaekaetaaveattaslqtaiiasivaivvIvLimvIIY.....LiLRYrRKkKmkkKlqyikL 318
                  + +++ +e + ++ + +++  + ++  i++ +v +vvI Li++II      L+LR +RK+  ++K    kL
  EFC38228.1 618 MSVKKTLSENKVQTSTYTSSDQSAVTIGITVGVVGVVVILLIILIIVifttvLLLRSKRKNAENRKKLQAKL 689
                 222222222222223333344455566677777777777766666532234488999999877766555565 PP

>> EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0       1.4   1.2e+03       9      33 ..       9      32 ..       3      65 .. 0.54
   2 !   14.2   0.4   7.8e-05     0.063       2      36 ..     651     685 ..     650     702 .. 0.56

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 1.4
    EphA2_TM  9 lvllvilvilvlvlvrrrsknrkqk 33
                 +l +i+ i++++l+++ ++ + q+
  EFC38228.1  9 TILHLIITIITTLLFSQLTQLD-QQ 32
                2333333444444443333333.22 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 7.8e-05
    EphA2_TM   2 iaaavaglvllvilvilvlvlvrrrsknrkqksdl 36 
                 ++++v+ l++l+i++ ++++l+r+++kn +++++l
  EFC38228.1 651 VGVVVILLIILIIVIFTTVLLLRSKRKNAENRKKL 685
                 55666666666666666666666666666666554 PP

>> DUF5305  Family of unknown function (DUF5305)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   3.0   2.8e-05     0.023      61     150 ..     588     684 ..     552     694 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.8e-05
     DUF5305  61 vegeidgesieesktsrlpiplteqtyeikkdetd..eengeitetvtvkespslae....gilliilgllaliglvvlirriiftssk.aekyele 150
                 ++ +id+++++   + +++ ++ +++  i+++ ++  +en+ +t t t +++  ++     g+++++++ll+++++v+++++ +  s+    + +++
  EFC38228.1 588 LNKTIDNTNFQVVISVKCETSHLTSFGVIDMSVKKtlSENKVQTSTYTSSDQSAVTIgitvGVVGVVVILLIILIIVIFTTVLLLRSKRkNAENRKK 684
                 5667888999999999999999999999999999977888888888888888888779999556666666555555555555333332213333333 PP

>> Stevor  Subtelomeric Variable Open Reading frame
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   2.1   3.6e-05     0.029     182     264 ..     592     679 ..     563     686 .. 0.51

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 3.6e-05
      Stevor 182 lsaealkklass.lsilnlfsesslesalkaavsaaaasdlagta.asaassafep...ygiaalvllilavvliiLYiwlyrRRKnS 264
                 + +++++ ++s+ +++ +l s   +  ++k+++s + ++  + t   ++a+++  +    g+++++l+il++v+    + l+ +RKn+
  EFC38228.1 592 IDNTNFQVVISVkCETSHLTSFGVIDMSVKKTLSENKVQTSTYTSsDQSAVTIGITvgvVGVVVILLIILIIVIFTTVLLLRSKRKNA 679
                 3334444333321233344444444445554444443333333332444444444400055555555555555555557888899986 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   1.2     7e-05     0.057      41      99 ..     621     682 ..     615     686 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 7e-05
       Orf78  41 ksaaeknditekesnaaekaqalnillisllavvcvlvllyviyYf...vilrerqkssvke 99 
                 k++ ++n++++++ +++ + +++  + ++++ vv++l+++ +i+ f   ++lr ++k+++++
  EFC38228.1 621 KKTLSENKVQTSTYTSSDQSAVTIGITVGVVGVVVILLIILIIVIFttvLLLRSKRKNAENR 682
                 45566667777676767788888889999999999888887777764334567777766654 PP

>> Protocadherin  Protocadherin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.6   9.2e-05     0.075      13      62 ..     617     664 ..     611     703 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 9.2e-05
  Protocadherin  13 arsletpldqdiagdpdveslskdrlkiliavlaGvvtvilvilivvlvR 62 
                      s++++l+++  +++ ++  s+d++ + i++  Gvv v++++li+ ++ 
     EFC38228.1 617 DMSVKKTLSENKVQTSTYT--SSDQSAVTIGITVGVVGVVVILLIILIIV 664
                    5677777777775666666..78888888888888877765554443332 PP

>> SKG6  Transmembrane alpha-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   9.3   0.00012     0.096       5      33 ..     637     666 ..     635     667 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00012
        SKG6   5 snsntvaIavaVa.VPVaViiivLlailif 33 
                 s  ++v+I++ V+ V+V+Vi++++l+i if
  EFC38228.1 637 SDQSAVTIGITVGvVGVVVILLIILIIVIF 666
                 357899999999626888888888888776 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.2       2.9   2.4e+03      16      26 ..      13      23 ..       4      42 .. 0.57
   2 ?   13.2   0.2    0.0001     0.084      19      61 ..     652     701 ..     643     703 .. 0.66

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 2.9
  Sigma_reg_N 16 vlislivllli 26
                  +i++i++ll+
   EFC38228.1 13 LIITIITTLLF 23
                 22333333333 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 0.0001
  Sigma_reg_N  19 slivlllifvil.vvtllyl......aekegnklrevlelaveitsPNvy 61 
                   ++v+lli++i+ ++t+  l      + ++ +kl  +l++ ++++sP + 
   EFC38228.1 652 GVVVILLIILIIvIFTTVLLlrskrkNAENRKKLQAKLQDQLKVSSPSTS 701
                  33444444444434444444588888888888999************875 PP

>> DUF4577  Domain of unknown function (DUF4577)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       6.3   5.1e+03      16      34 ..     130     149 ..     125     157 .. 0.74
   2 ?   -2.2   0.0       4.8   3.9e+03      12      30 ..     185     203 ..     180     209 .. 0.76
   3 ?   11.7   1.1   0.00025       0.2      62     105 ..     648     691 ..     608     696 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 6.3
     DUF4577  16 drklyvvdsindl.nklnlc 34 
                 ++ ly+ +s n++ +klnl+
  EFC38228.1 130 ENALYIAESGNNIiRKLNLM 149
                 67799999988752568886 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 4.8
     DUF4577  12 dihedrklyvvdsindlnk 30 
                 d+  ++ ly+ d++n + +
  EFC38228.1 185 DTTTQKYLYISDTLNHIVR 203
                 5667889*******98744 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 0.00025
     DUF4577  62 lffvgliivlivslalvsfvifliiqtgskmddvsrrltaegkd 105
                 + +vg++++l++ l +v f ++l++++  k  +  ++l+a  +d
  EFC38228.1 648 VGVVGVVVILLIILIIVIFTTVLLLRSKRKNAENRKKLQAKLQD 691
                 5579**************************99999999998776 PP

>> MpPF26  M penetrans paralogue family 26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1      0.47   3.8e+02      67      93 ..       7      33 ..       3      41 .. 0.67
   2 ?   12.4   1.8   0.00015      0.13      41      95 ..     629     680 ..     590     692 .. 0.64

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.47
      MpPF26 67 lidifyivnfileiiLiiKvselkkkh 93
                +++i+ +++ i++++L+  + +l ++h
  EFC38228.1  7 SMTILHLIITIITTLLFSQLTQLDQQH 33
                456666777777777777666666655 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 0.00015
      MpPF26  41 kllskeyeeesslleaelligvllillidifyivnfileiiLiiKvselkkkhpe 95 
                   +s + +  +s + + + +gv+ +++i +++++++i++++L ++ ++ +    e
  EFC38228.1 629 VQTSTYTSSDQSAVTIGITVGVVGVVVILLIILIIVIFTTVLLLRSKRKNA---E 680
                 233334444455555556666666666666999999999999988653333...3 PP

>> DAG1  Dystroglycan (Dystrophin-associated glycoprotein 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.7   0.00017      0.14      82     208 ..     579     702 ..     519     704 .] 0.59

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00017
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXX.XXXXXXX CS
        DAG1  82 slreafkralePelkltnisvvgssscrhlefiplnqleeiPsevasteapeedaeksseddvylhtvipavv.vaailliagiiamicyr.kkrkGkl 178
                  l+ ++   l+  +  tn+ vv s  c+  +       +   +++ s + +++++  ss +    + +   vv v++illi  ii++       r+ + 
  EFC38228.1 579 GLKTTILSFLNKTIDNTNFQVVISVKCETSHLTSFGVIDMSVKKTLSENKVQTSTYTSSDQSAVTIGITVGVVgVVVILLIILIIVIFTTVlLLRSKRK 677
                 3555566678889999***********986665555555555555666666666666666655555444433326666666655554432223444444 PP

                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        DAG1 179 tledqatfikkGvPiifadelddskPeiss 208
                 + e+++ + +k     ++d+l+ s P  ss
  EFC38228.1 678 NAENRKKLQAK-----LQDQLKVSSPSTSS 702
                 66777777776.....56666666666655 PP

>> SP_C-Propep  Surfactant protein C, N terminal propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.9   1.5e+03       8      29 ..     367     388 ..     360     395 .. 0.76
   2 ?    9.9   0.3   0.00073      0.59       1      52 [.     616     670 ..     616     685 .. 0.63

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.9
  SP_C-Propep   8 ilmesalpppdysaasrgrlri 29 
                  ++me +    +ys  s+g l +
   EFC38228.1 367 LMMEYSCNSTNYSINSNGTLCV 388
                  467889999*********9976 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00073
  SP_C-Propep   1 mdvgskeilmesalpppdysaasrgrlripcc..plnlkrll.ivvvvvvlvvvv 52 
                  +d+  k+ l e+ +    y+++ +  + i      + +  +l i++++v++  v+
   EFC38228.1 616 IDMSVKKTLSENKVQTSTYTSSDQSAVTIGITvgVVGVVVILlIILIIVIFTTVL 670
                  5999***************999999887754300333332220222222222222 PP

>> DUF3278  Protein of unknown function (DUF3278)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       9.2   7.5e+03      39      55 ..      10      26 ..       3      36 .. 0.57
   2 ?   10.6   1.4   0.00056      0.46      49     128 ..     582     659 ..     574     680 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 9.2
     DUF3278 39 illwlyllilslvalll 55
                il +++++i +l+++ l
  EFC38228.1 10 ILHLIITIITTLLFSQL 26
                44455555555554444 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00056
     DUF3278  49 slvalllakktpeselilglvltnlllvvlvsglYiliaskklglatkeveakdyekavkkivlksikfglyfaivlyll 128
                 + + ++l k +++ +   ++v+++   +   ++  ++  s k  l +++v++++y++  + +v  +i +g+++++v++l+
  EFC38228.1 582 TTILSFLNKTIDNTNF--QVVISVKCETSHLTSFGVIDMSVKKTLSENKVQTSTYTSSDQSAVTIGITVGVVGVVVILLI 659
                 5566677777666433..34444444444555555666677889*******************************99875 PP

>> DUF4006  Family of unknown function (DUF4006)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.2       1.5   1.2e+03      19      49 ..      17      48 ..      14      53 .. 0.84
   2 ?   -2.0   0.0       4.3   3.5e+03      46      63 ..     115     132 ..     112     134 .. 0.82
   3 ?    9.6   0.5     0.001      0.83      13      59 ..     649     697 ..     645     703 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.5
     DUF4006 19 iavvLLLsilavLtvlaikvqqaeatnyYk.l 49
                i++ LL s l  L    ++ q      +Yk +
  EFC38228.1 17 IITTLLFSQLTQLDQQHVNGQLTPTATSYKtI 48
                899**********9999999999888888834 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 4.3
     DUF4006  46 yYkledldsvkmiskdna 63 
                 y kl+++ ++ m+ ++na
  EFC38228.1 115 YSKLNEPRQITMSTTENA 132
                 44599********99997 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.001
     DUF4006  13 GitGmliavvLLLsilavLtvlaikvqqaeatnyYk..ledldsvkmis 59 
                 G++G +++  + L i+++ tvl + +++++a+n  k   +  d++k +s
  EFC38228.1 649 GVVGVVVILLIILIIVIFTTVLLLRSKRKNAENRKKlqAKLQDQLKVSS 697
                 99******************************98884444456666655 PP

>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.3       3.7     3e+03      47      60 ..      13      26 ..       5      39 .. 0.42
   2 ?   10.4   1.7   0.00044      0.36      44      75 ..     650     681 ..     644     692 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 3.7
  Baculo_11_kDa 47 vvivlfilLlvvil 60
                   ++i++  +Ll++ l
     EFC38228.1 13 LIITIITTLLFSQL 26
                   22222223333322 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00044
  Baculo_11_kDa  44 vvfvvivlfilLlvvilknaeaeeaekekrek 75 
                    vv vv++l+i+L++vi++++ + + ++++ e+
     EFC38228.1 650 VVGVVVILLIILIIVIFTTVLLLRSKRKNAEN 681
                    67788888888888998888877777776654 PP

>> DUF3377  Domain of unknown function (DUF3377)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.6   0.00049       0.4      26      57 ..     647     679 ..     627     686 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00049
     DUF3377  26 tvnaiaVvv.PlvLllciLvliyailqfrrkgt 57 
                 tv+++ Vvv  l+ l++++++++ +l+ +rk +
  EFC38228.1 647 TVGVVGVVViLLIILIIVIFTTVLLLRSKRKNA 679
                 466776655155555566666666666777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (704 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1249  (0.0696637); expected 358.6 (0.02)
Passed bias filter:                      617  (0.0344135); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              22  [number of targets reported over threshold]
# CPU time: 0.82u 0.32s 00:00:01.13 Elapsed: 00:00:00.51
# Mc/sec: 4174.23
//
Query:       EFC38229.1  [L=1835]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.9e-49  163.9 257.6    1.3e-05   25.4   5.0   17.9 17  EGF_2           EGF-like domain
    3.8e-23   82.0  19.2    7.2e-20   71.2  13.6    2.9  2  REJ             REJ domain
  ------ inclusion threshold ------
      0.015   15.5  15.1       0.16   12.1   0.1    5.2  5  PKD_2           PKD-like family
       0.12   12.6   0.2       0.33   11.2   0.2    1.7  1  Chordopox_A13L  Chordopoxvirus A13L protein


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.5   5.5         4   1.8e+04       5      23 ..      32      48 ..      20      56 .. 0.63
   2 !   21.2   8.0   6.2e-08   0.00028       5      32 .]     241     267 ..     237     267 .. 0.87
   3 !   25.2   9.5   3.6e-09   1.6e-05       5      32 .]     280     306 ..     272     306 .. 0.87
   4 !   20.0   8.8   1.4e-07   0.00065       5      32 .]     319     345 ..     315     345 .. 0.91
   5 !   19.1   7.8   2.7e-07    0.0012       5      32 .]     358     384 ..     355     384 .. 0.92
   6 !   25.4   5.0   2.9e-09   1.3e-05       6      32 .]     398     423 ..     393     423 .. 0.91
   7 !   23.0  11.3   1.7e-08   7.5e-05       5      32 .]     436     462 ..     428     462 .. 0.89
   8 !   16.2   9.5   2.2e-06    0.0099       4      32 .]     474     501 ..     470     501 .. 0.91
   9 !   22.0   6.9   3.4e-08   0.00015       4      32 .]     513     540 ..     509     540 .. 0.91
  10 !   22.2   9.3   2.9e-08   0.00013       5      32 .]     553     579 ..     549     579 .. 0.91
  11 !   22.2   9.3   2.9e-08   0.00013       5      32 .]     592     618 ..     588     618 .. 0.91
  12 ?    1.1  23.7      0.12   5.2e+02       4      32 .]     644     672 ..     627     672 .. 0.74
  13 !   19.1   6.7   2.8e-07    0.0013       4      32 .]     683     716 ..     681     716 .. 0.90
  14 !   10.5  11.7   0.00014      0.62       1      32 []     734     768 ..     734     768 .. 0.79
  15 ?   -3.4   0.1       3.1   1.4e+04      23      32 .]     771     780 ..     770     780 .. 0.89
  16 !   12.9   2.2   2.5e-05      0.11       5      32 .]    1459    1484 ..    1454    1484 .. 0.87
  17 ?    0.7   0.4      0.15   6.9e+02      18      25 ..    1753    1760 ..    1749    1763 .. 0.71

  Alignments for each domain:
  == domain 1  score: -5.5 bits;  conditional E-value: 4
       EGF_2  5 deiCgghGtCvnqcGqCdC 23
                +++Cgg  +C  ++  C C
  EFC38229.1 32 NSTCGG-NICYGEN-SCLC 48
                455654.3565333.5888 PP

  == domain 2  score: 21.2 bits;  conditional E-value: 6.2e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghGtC +    C+C+++y+G++C
  EFC38229.1 241 STVCSGHGTCTAID-TCKCETNYFGADC 267
                 678*******8555.8************ PP

  == domain 3  score: 25.2 bits;  conditional E-value: 3.6e-09
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+ghG+Cv+++ +C+C sgy+G++C
  EFC38229.1 280 HNVCSGHGSCVAPN-NCSCLSGYSGADC 306
                 689********999.8************ PP

  == domain 4  score: 20.0 bits;  conditional E-value: 1.4e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+ghG+C++++ +C+C  gy+G +C
  EFC38229.1 319 ASVCSGHGSCIAPN-NCSCTYGYYGSNC 345
                 568********999.8************ PP

  == domain 5  score: 19.1 bits;  conditional E-value: 2.7e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G+C +++ +C+C++ y+G++C
  EFC38229.1 358 SSVCSSQGICLSPN-NCSCSNDYYGNDC 384
                 578********999.8************ PP

  == domain 6  score: 25.4 bits;  conditional E-value: 2.9e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C++hGtC +++ +C+C +gy+G +C
  EFC38229.1 398 SACSVHGTCLSPN-NCSCLAGYSGSDC 423
                 68********999.8************ PP

  == domain 7  score: 23.0 bits;  conditional E-value: 1.7e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+g+G+C++++ +C+C sgy+G+ C
  EFC38229.1 436 SSACSGNGYCIAPN-NCSCTSGYYGNEC 462
                 789********999.8************ PP

  == domain 8  score: 16.2 bits;  conditional E-value: 2.2e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C ghG C++++ +C+C++ ++G++C
  EFC38229.1 474 SGSVCFGHGDCISPN-NCSCSNEHYGNDC 501
                 4899********999.8************ PP

  == domain 9  score: 22.0 bits;  conditional E-value: 3.4e-08
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C+  G Cv+++ +C+C +gy+G++C
  EFC38229.1 513 SGSVCSSYGRCVSPN-NCSCLAGYYGNDC 540
                 4899********999.8************ PP

  == domain 10  score: 22.2 bits;  conditional E-value: 2.9e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+ghG C++++ +C+C +gy+G++C
  EFC38229.1 553 ASACSGHGGCISPN-NCSCLDGYYGNDC 579
                 678********999.8************ PP

  == domain 11  score: 22.2 bits;  conditional E-value: 2.9e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  ++C+ghG C++++ +C+C +gy+G++C
  EFC38229.1 592 ASACSGHGGCISPN-NCSCLDGYYGNDC 618
                 678********999.8************ PP

  == domain 12  score: 1.1 bits;  conditional E-value: 0.12
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C g G C+ +   C+C+sgy+G +C
  EFC38229.1 644 NnCSSCYGKGRCDFFD-HCSCQSGYYGSHC 672
                 2466677777777555.8************ PP

  == domain 13  score: 19.1 bits;  conditional E-value: 2.8e-07
       EGF_2   4 s.deiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                 + ++ C+ghG+C +++  C+C     +  ++G++C
  EFC38229.1 683 NaSSVCSGHGQCTDLN-ICVCdniagKGYWTGADC 716
                 45789*******9888.****************** PP

  == domain 14  score: 10.5 bits;  conditional E-value: 0.00014
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                 C a +++C+g+G+C++++ qC C     +  + G +C
  EFC38229.1 734 CNA-STTCSGNGYCNELE-QCTCyadnkKGFWKGESC 768
                 777.599***********.****88774455567777 PP

  == domain 15  score: -3.4 bits;  conditional E-value: 3.1
       EGF_2  23 CdsgyqGktC 32 
                 C +g +G  C
  EFC38229.1 771 CADGVYGELC 780
                 9999999999 PP

  == domain 16  score: 12.9 bits;  conditional E-value: 2.5e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +C+ghG+ v  +G+C+C++ y+  +C
  EFC38229.1 1459 KKDCSGHGSLV--NGKCVCEADYTTFDC 1484
                  568********..********9998777 PP

  == domain 17  score: 0.7 bits;  conditional E-value: 0.15
       EGF_2   18 cGqCdCds 25  
                   GqC+C+ 
  EFC38229.1 1753 SGQCECSE 1760
                  48999965 PP

>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.1   1.7e-05     0.077       7      71 ..     917     981 ..     909    1004 .. 0.86
   2 !   71.2  13.6   1.6e-23   7.2e-20     110     428 ..    1116    1417 ..    1020    1434 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.7e-05
         REJ   7 CieaekllynWtvfeltsgngnqentrklnttepqltippsfLpygtyvflltvslsgepsleat 71 
                 + ++++l ++Wtv++++++ ++q++ ++   + ++l+i+ s + +g ++f l v+ +  + + ++
  EFC38229.1 917 SPDRKTLNFKWTVLSSPNKVELQKLLDSTLASPSKLNISYSGMNAGVHQFELAVTSQVYSLVDKI 981
                 678899*********************9999888*********************9877655555 PP

  == domain 2  score: 71.2 bits;  conditional E-value: 1.6e-23
         REJ  110 DpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltvskrsrksasteqtilvvdgepplv. 205 
                  D  ++++++ q +Y+W+c+++         n++   d +++     +    + ++ +s + +  +  ++lt++k+sr  +s++   + ++ e  ++ 
  EFC38229.1 1116 DFTDPESENVQPTYSWTCVDTV-------TNTVCPVDVVNYL---SQGFLEQYKIEKSMFGSAENVRISLTIRKGSRFVQSSVDLNFPQQAEHLIMp 1202
                  444444445889******5555.......3333333333333...455567999**********************866666665555555544443 PP

         REJ  206 .siecisncngkvnpndrlvllas.clncakdlkdvt.feWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkks 299 
                    i+ ++  + kvn+ d ++++ + + n + ++ ++   +W   ++ +  + +++  +   ++++ +  L +++++L++g+s +++l++ dk+ +++
  EFC38229.1 1203 pLISVVQVSSSKVNKGDYVNIQLVvTINGDLNIDQFIsRTW--LLNDKAIDAILT--SPMSISSSLSNSLILDTQYLDEGSSNTISLTILDKRNNQK 1295
                  36899999999999999988888877777666555555889..444444445555..555666666778******************9999998888 PP

         REJ  300 glasisfkvnepPtgGtcsvtPlegvaletaftvrCqgwtDkdqPLgYev.sysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyD 395 
                     s+sf+vn pP  ++c + P++g+al+t ft++C++ +++++  +Y++ + + ++ sg   +l++ +   +   +LP++++  +++++++v+V D
  EFC38229.1 1296 TSYSYSFSVNRPPKACSCAISPTSGIALTTIFTFNCENCQNDKK--TYAFeYGFIDDFSGALITLSKDE---ELYQKLPTPNS--GNNLELYVKVID 1385
                  8***********************************99955554..47773344666677555554444...55899**9999..889********* PP

         REJ  396 nkgarv.svsltitVkppavnnstieellenrtr 428 
                  +  +++   ++++++++p v++   ++++e++t+
  EFC38229.1 1386 TETSATtLSKKSVQITAPYVSKV--KDIKEYMTK 1417
                  ***999788899*********99..888877775 PP

>> PKD_2  PKD-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.063   2.8e+02      35     102 ..     905     981 ..     889     994 .. 0.70
   2 ?    2.6   1.1      0.03   1.4e+02      46     129 ..    1029    1114 ..    1001    1130 .. 0.63
   3 ?    4.7   0.1    0.0072        32      25     124 ..    1213    1320 ..    1198    1330 .. 0.71
   4 ?   12.1   0.1   3.6e-05      0.16      44     114 ..    1335    1406 ..    1314    1411 .. 0.78
   5 ?   -0.4   0.2      0.26   1.2e+03      32      68 ..    1648    1693 ..    1628    1734 .. 0.59

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.063
       PKD_2  35 ikpklttasek...deeeleyeWkiiks.....skslkidtiseeedldvvvd.leakkyslrlsvtdkktgityfa 102
                 ++  l+ ase    d ++l+++W++ +s      ++l   t++  ++l++ ++  +a+ +++ l+vt +   +++  
  EFC38229.1 905 CEDVLIDASESyspDRKTLNFKWTVLSSpnkveLQKLLDSTLASPSKLNISYSgMNAGVHQFELAVTSQVYSLVDKI 981
                 44445555555555678********9888776555566678888889999987367778999999987766665555 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.03
       PKD_2   46 deeeleyeWkiiksskslkidtiseeedldvvv..dleakkyslrlsvtdkktgityfaet.sl.evkkpyskgwmvLsekggkaelg 129 
                   +++++y+W++i+    +   t+   ++l+++   + e+ +y +  s  d+++  ++++ + ++ +v +++s  ++vL ++ + +++g
  EFC38229.1 1029 SAANIDYTWTQISG--PQVEFTVDSFKNLKITNfnTIETRQYVFKVSAFDTSNVNKFSTALvTIdTVAQALSMNMYVLDSTPQYSTIG 1114
                  5789*******775..444445555556665541144555677777777766544444443233234456688999998887777665 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.0072
       PKD_2   25 ysvalgetlkikpklttasek.deeeleyeWkiiks.......skslkidtiseeedldvvvdleakkyslrlsvtdkktgityfaetslevkkpys 113 
                  ++v++g+ ++i+  +t + +   ++ ++ +W  + +       s+     ++s++  ld+++  e ++ ++ l++ dk+++ ++++++s +v+ p +
  EFC38229.1 1213 SKVNKGDYVNIQLVVTINGDLnIDQFISRTWLLNDKaidailtSPMSISSSLSNSLILDTQYLDEGSSNTISLTILDKRNNQKTSYSYSFSVNRPPK 1309
                  55666666666555554444334555677788766677755544455556777778899999999999********************999998877 PP

       PKD_2  114 kgwmvLsekgg 124 
                   +   +s ++g
  EFC38229.1 1310 ACSCAISPTSG 1320
                  77776666655 PP

  == domain 4  score: 12.1 bits;  conditional E-value: 3.6e-05
       PKD_2   44 ekdeeeleyeWkiiksskslkidtiseeedldvvvdleak..kyslrlsvtdkktgityfaetslevkkpysk 114 
                  ++d++++++e  +i    s++  t+s++e+l  ++ +  +  + +l  +v+d++t  t+  ++s+++++py++
  EFC38229.1 1335 QNDKKTYAFEYGFIDD-FSGALITLSKDEELYQKLPTPNSgnNLELYVKVIDTETSATTLSKKSVQITAPYVS 1406
                  3356788888888664.888999999999987777665553378888899*********************54 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.26
       PKD_2   32 tlkikpklttasek..deeeleyeWkiiks.......skslkidti 68  
                  +l++  +++++ +     + ++y W+iik        ++++ ++ti
  EFC38229.1 1648 SLTLPSTVSQRLQSvsLRKPVNYIWMIIKDvsqyvtpQQEGTTNTI 1693
                  4555455555555554567799999998875555533333333333 PP

>> Chordopox_A13L  Chordopoxvirus A13L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.2   7.3e-05      0.33       6      36 ..    1793    1823 ..    1790    1834 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 7.3e-05
  Chordopox_A13L    6 llliiCvaivglivYgiYnrkketqttnpst 36  
                      ++liiC +i+++iv gi+     +  ++  t
      EFC38229.1 1793 AFLIICFIIIAFIVLGIFGYCVVKRMKPETT 1823
                      689**************97666555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1835 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       925  (0.0515924); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.15u 0.38s 00:00:01.52 Elapsed: 00:00:00.57
# Mc/sec: 9754.97
//
Query:       EFC38230.1  [L=141]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-06   27.9  98.8     0.0081   16.1  36.8    3.0  3  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1  36.8   4.5e-07    0.0081      57     111 ..       4      58 ..       1      60 [. 0.50
   2 !    4.6  49.9    0.0017        30      63     106 ..      46      89 ..      33     102 .. 0.27
   3 !   13.1  38.6     4e-06     0.072      59     111 ..      82     134 ..      80     139 .. 0.52

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 4.5e-07
  Trypan_PARP  57 tdpepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  t+++p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC38230.1   4 TQTQPKPKPKPKPKPKPKPGPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 58 
                  4455555555555555555555555555555555555555555555555555544 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0017
  Trypan_PARP  63 pepepepepepepepepetepeeepepepepepepepepepepe 106
                  p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+
   EFC38230.1  46 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPK 89 
                  11111111111111111111111111111111111111111111 PP

  == domain 3  score: 13.1 bits;  conditional E-value: 4e-06
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC38230.1  82 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 134
                  44555555555555555555555555555555555555555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       215  (0.0119917); expected 358.6 (0.02)
Passed bias filter:                       80  (0.00446204); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        33  (0.00184059); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.79u 0.34s 00:00:01.13 Elapsed: 00:00:00.52
# Mc/sec: 822.03
//
Query:       EFC38231.1  [L=636]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.5e-23   80.8   0.0    1.4e-22   80.2   0.0    1.3  1  Pkinase_Tyr      Protein tyrosine kinase
    5.8e-20   71.8   0.0    9.3e-20   71.1   0.0    1.3  1  Pkinase          Protein kinase domain
     0.0088   14.8   0.2      0.015   14.0   0.2    1.3  1  Adeno_E1B_55K    Adenovirus EB1 55K protein / large t-antigen
     0.0092   15.3   0.0      0.013   14.8   0.0    1.2  1  DUF4436          Domain of unknown function (DUF4436)
  ------ inclusion threshold ------
       0.13   11.5   0.0       0.21   10.8   0.0    1.2  1  Fructosamin_kin  Fructosamine kinase
       0.26   11.8   0.1       0.26   11.8   0.1    5.8  7  Chlam_PMP        Chlamydia polymorphic membrane protein (Chla


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.2   0.0   4.8e-26   1.4e-22       2     127 ..     512     636 .]     511     636 .] 0.93

  Alignments for each domain:
  == domain 1  score: 80.2 bits;  conditional E-value: 4.8e-26
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ek 97 
                  e+ k++GeG+ G+V++++++       ++Va+K++k ++ + +++e+ +ea+++++l+hp iv+++gv +++ + ++v+ey+++G+L+  + ++   +
   EFC38231.1 512 EIVKRIGEGSMGTVYMASWN------GITVALKSIKTDSFDISEDEFEHEASLLNSLRHPSIVRFYGVSLSNTNKYMVVEYLENGSLDAIIAQSkcGR 603
                  7889****************......9****************************************************************9995568 PP

                  TTSBHHHHHHHHHHHHHHHHHHHHTT...EEES CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskk...lvHr 127
                  ++l+lk+++++   +A+Gm+yL+s k   l+Hr
   EFC38231.1 604 RTLDLKSKIEILKGIASGMDYLHSLKprsLIHR 636
                  99********************99544448887 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.1   0.0   3.1e-23   9.3e-20       2     122 ..     512     636 .]     511     636 .] 0.90

  Alignments for each domain:
  == domain 1  score: 71.1 bits;  conditional E-value: 3.1e-23
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS-- CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsls 96 
                 e ++++GeGs+G+Vy a   ++g +vA+K ik+++ + ++ +++ +E ++l++l+hp ivr+y+v  ++++ y+v+ey+e+g+l+ ++      +++l+
  EFC38231.1 512 EIVKRIGEGSMGTVYMAS--WNGITVALKSIKTDSFDISE-DEFEHEASLLNSLRHPSIVRFYGVSLSNTNKYMVVEYLENGSLDAIIAqskcGRRTLD 607
                 56899************9..9************9998877.59*********************************************96665556677 PP

                 HHHHHHHHHHHHHHHHHHHHTT...EE-S CS
     Pkinase  97 eeeakkiakqilegleylHskg...iiHr 122
                  +   +i+k i++g++ylHs +   +iHr
  EFC38231.1 608 LKSKIEILKGIASGMDYLHSLKprsLIHR 636
                 77888**************9775667776 PP

>> Adeno_E1B_55K  Adenovirus EB1 55K protein / large t-antigen
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.2   5.1e-06     0.015     113     197 ..      56     138 ..      39     190 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 5.1e-06
  Adeno_E1B_55K 113 slgpgvvgmegvtflnvrFerektangvvflantevllhgcsFlgfsgtcveltagvevrGCsFvacykgivsrsksklkvkkcv 197
                    + +  vvgm+++++ n +F+ ++  + +++  ++  ++ g + ++ + + +e  +  e+ GC+F+ + k+++  ++ k++  +++
     EFC38231.1  56 NTSLNVVGMNSLILDNSIFTTNS--SLSIVGISKVRIFRGNFSYNSNALSMEYVTSIELIGCNFIRNLKPLRVVNRPKVTTGSNI 138
                    56678***************999..6677777777888898889*************************9976655554433333 PP

>> DUF4436  Domain of unknown function (DUF4436)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   4.5e-06     0.013      97     191 ..     361     459 ..     306     467 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.5e-06
     DUF4436  97 diedwPFdrYrtgsltaevvvgagsdaapvpvrveltgrlegwdltvkrseea...dkaaavevtlaRskstlifalvi.vlvlialpvlalivaiqvl 191
                 +i   PFd  + + l++ v   ++  ++ ++++v +++r+  +++ +  ++ +   + ++ ++v   Rs+  +i+a+v  vl+l++   ++l+  ++++
  EFC38231.1 361 NIVTNPFDVNSNTFLNVYVQAPNDRMEHILNASVAFSDRDFTFEFGIRVERCPfdyAFDSSTNVCTFRSHTAIILAVVFgVLILFIFMGVGLVSCVKIT 459
                 67888*****9999******************************9999998888889999999999*********988746666677777777766665 PP

>> Fructosamin_kin  Fructosamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   6.9e-05      0.21      19      98 ..     511     592 ..     495     610 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 6.9e-05
  Fructosamin_kin  19 iteaekveggeineayllseeeqrfFvklne....kealemFeaEaesLealaetqtirvPkvlavGelkdasfLvleyLelk.l 98 
                      i+  ++++ g++ + y+ s +  ++ +k  +      +++ Fe+Ea  L+ l++ + +   + + v+ +++++++v+eyLe + l
       EFC38231.1 511 IEIVKRIGEGSMGTVYMASWNGITVALKSIKtdsfDISEDEFEHEASLLNSLRHPSIV---RFYGVSLSNTNKYMVVEYLENGsL 592
                      5566788889999999999888888877655333556778899999999999665555...68999***************9844 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.8         6   1.8e+04       2       9 ..      72      79 ..      71      82 .. 0.80
   2 ?   -2.6   0.4       3.4     1e+04       4       9 ..      91      96 ..      90     102 .. 0.56
   3 ?   11.8   0.1   8.8e-05      0.26       1      28 []     143     160 ..     143     160 .. 0.92
   4 ?    9.5   0.4    0.0005       1.5      16      27 ..     173     184 ..     161     185 .. 0.77
   5 ?    4.5   0.1     0.019        57      14      27 ..     209     222 ..     187     223 .. 0.75
   6 ?   -0.7   0.2      0.87   2.6e+03       3      23 ..     234     244 ..     232     244 .. 0.78
   7 ?   -1.4   0.0       1.4   4.2e+03       2       9 ..     256     263 ..     255     267 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 6
   Chlam_PMP  2 itFsnNta 9 
                 +F+ N++
  EFC38231.1 72 SIFTTNSS 79
                58999998 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 3.4
   Chlam_PMP  4 FsnNta 9 
                F +N +
  EFC38231.1 91 FRGNFS 96
                555655 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 8.8e-05
   Chlam_PMP   1 sitFsnNtatvsstptpaaggGGAIyae 28 
                 s++F  Nta           +GGAIy+e
  EFC38231.1 143 SCLFVENTA----------QYGGAIYSE 160
                 589******..........*******96 PP

  == domain 4  score: 9.5 bits;  conditional E-value: 0.0005
   Chlam_PMP  16 tpaaggGGAIya 27 
                 +++a++GGAIy 
  EFC38231.1 173 SNKAANGGAIYV 184
                 6677*******6 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.019
   Chlam_PMP  14 tptpaaggGGAIya 27 
                 +  + +g+GGA y+
  EFC38231.1 209 NNPEECGNGGAVYS 222
                 556779******96 PP

  == domain 6  score: -0.7 bits;  conditional E-value: 0.87
   Chlam_PMP   3 tFsnNtatvsstptpaaggGG 23 
                 ++++N+a          ++GG
  EFC38231.1 234 VINGNQA----------VKGG 244
                 689****..........7776 PP

  == domain 7  score: -1.4 bits;  conditional E-value: 1.4
   Chlam_PMP   2 itFsnNta 9  
                 ++ snN a
  EFC38231.1 256 LLMSNNRA 263
                 6679***9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (636 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       775  (0.0432261); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.47
# Mc/sec: 4040.37
//
Query:       EFC38232.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.1e-13   50.3   0.0    3.3e-13   49.6   0.0    1.3  1  Pkinase      Protein kinase domain
    7.1e-12   45.1   0.1    4.7e-05   22.8   0.1    2.1  2  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.6   0.0   3.6e-17   3.3e-13     151     260 ..       7     157 ..       1     159 [. 0.76

  Alignments for each domain:
  == domain 1  score: 49.6 bits;  conditional E-value: 3.6e-17
                 SCSBCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHHTTS........... CS
     Pkinase 151 sskltsfvgtseYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasei........... 233
                 ss++t   gt  Y+APE++ ++ e++++ Dv+s+ +i+yel++++ p+s + +++ ++   +        l+     +++++     i           
  EFC38232.1   7 SSTMTMNLGTIFYMAPEIIgSGYEIGSSLDVYSYSMIMYELFFEEKPYSPTYSTKMTKFSPNS------SLDssrdSQQFAFS----Iplkvlkcerpn 95 
                 445999*************777888************************44443322222222......22211122222222....144446677777 PP

                 ...................................-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 234 ...................................seeakdllkkllkkdpkkRltaeellq 260
                                                     +e ++l+++++++ p++R+ ++e+ q
  EFC38232.1  96 ipwnnsqefegwidefvkpyqsssssggglnhsgvCSEYIELMQQCWDQVPSNRPNFKEIGQ 157
                 77777789***************************99********************99866 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.1   5.2e-09   4.7e-05     163     216 ..      11      64 ..       1      85 [. 0.80
   2 !   20.7   0.0   2.3e-08    0.0002     230     259 .]     130     159 ..     114     159 .. 0.87

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 5.2e-09
                  TSSTSGGGGS-HHHHHHSE.EEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHH CS
  Pkinase_Tyr 163 eeaklpvkWmapEslkekk.ftsksDvWsfGvllwEiftlgespypglkneevle 216
                  + +   + +mapE++ ++  + s+ Dv+s++++++E+f   e+py+   ++++++
   EFC38232.1  11 TMNLGTIFYMAPEIIGSGYeIGSSLDVYSYSMIMYELFF-EEKPYSPTYSTKMTK 64 
                  55566899*******8765489999*************9.799998887777665 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 2.3e-08
                  SBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 230 cpeelyelmkkcweedpeeRptfselvekl 259
                  +++e  elm++cw++ p++Rp+f+e+ ++l
   EFC38232.1 130 VCSEYIELMQQCWDQVPSNRPNFKEIGQQL 159
                  5678889*******************8876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       456  (0.0254337); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.46
# Mc/sec: 1089.70
//
Query:       EFC38233.1  [L=684]
Description: hypothetical protein NAEGRDRAFT_73917 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.4e-32  109.6  30.8    0.00067   20.4   0.1   11.2 11  WD40         WD domain, G-beta repeat
    2.5e-16   59.7   4.8      4e-07   30.3   0.0    7.9  9  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    2.2e-08   33.8   0.0    6.1e-08   32.4   0.0    1.8  1  HELP         HELP motif
    0.00066   19.6   0.0          7    7.2   0.1    4.6  4  Reg_prop     Two component regulator propeller
  ------ inclusion threshold ------
       0.45   11.1   7.3         20    5.8   0.4    4.9  5  PQQ_3        PQQ-like domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.1   1.9e-07   0.00067       3      38 .]      80     118 ..      78     118 .. 0.91
   2 ?    3.1   0.0     0.055     2e+02      12      27 ..     139     155 ..     126     165 .. 0.70
   3 ?    5.4   0.0      0.01        37       1      32 [.     173     204 ..     173     209 .. 0.77
   4 !   10.7   0.0   0.00023      0.81       2      37 ..     218     253 ..     217     254 .. 0.89
   5 !   12.2   0.1   7.2e-05      0.26       9      38 .]     265     293 ..     256     293 .. 0.74
   6 !   19.3   0.3   4.3e-07    0.0016       4      38 .]     347     382 ..     344     382 .. 0.94
   7 ?   -0.5   0.0      0.74   2.7e+03      14      33 ..     400     419 ..     385     422 .. 0.64
   8 !   13.7   0.0   2.6e-05     0.092      13      38 .]     445     470 ..     434     470 .. 0.88
   9 !   16.9   0.1   2.4e-06    0.0084       2      38 .]     476     513 ..     475     513 .. 0.86
  10 ?    4.2   0.5     0.025        90      11      38 .]     552     579 ..     543     579 .. 0.88
  11 !   16.0   0.7   4.6e-06     0.017       6      33 ..     591     619 ..     586     624 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.9e-07
                 EEEEEESS.SSEEEEEEETTSSEEEEE..ETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasG..sdDgtvriWd 38 
                 +++++  H ++v +la +p+g+++asG  ++D  ++iWd
  EFC38233.1  80 TQKVFCKHdDDVVALAKHPNGRYFASGqmGKDDMIYIWD 118
                 6788889*77799**************9999*******9 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.055
                 S.EEEEEEETTSSEEEE CS
        WD40  12 s.vtslafspdgawlas 27 
                 + v  ++fs +g++la+
  EFC38233.1 139 GgVLTCCFSTEGSLLAC 155
                 2586777*******985 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.01
                 TEEEEEEESSSS.EEEEEEETTSSEEEEEETTS CS
        WD40   1 gqclrtltGHss.vtslafspdgawlasGsdDg 32 
                 g+cl   +G +  v++l+fs+d + l  ++ ++
  EFC38233.1 173 GTCLANVKGTNEeVYALCFSKDDNNLYLCG-KN 204
                 5799999999445**********9985355.55 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00023
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 +c+   +G  ++v++++ +++g+ ++ G +Dg+++i+
  EFC38233.1 218 NCVFRPKGSiQNVYCICLDDNGNAVV-GVEDGSIYIF 253
                 677788899889************97.*99****996 PP

  == domain 5  score: 12.2 bits;  conditional E-value: 7.2e-05
                 SS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   9 GH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +H + v+s+  s+  + ++sG++Dg v++W+
  EFC38233.1 265 AHtGAVYSV--SRFRNGFVSGGKDGVVKFWS 293
                 675559999..444444889**********5 PP

  == domain 6  score: 19.3 bits;  conditional E-value: 4.3e-07
                 EEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 l ++  H +  ++la+ ++++++a++sdDg v +Wd
  EFC38233.1 347 LSHFGNHlKELWGLATFKNSSLFATASDDGRVIVWD 382
                 6789999999*************************9 PP

  == domain 7  score: -0.5 bits;  conditional E-value: 0.74
                 EEEEEETTSSEEEEEETTSE CS
        WD40  14 tslafspdgawlasGsdDgt 33 
                 +++a+spd+  +a+ ++ g+
  EFC38233.1 400 RAVAVSPDHFHIATTTKEGS 419
                 45669999999988776666 PP

  == domain 8  score: 13.7 bits;  conditional E-value: 2.6e-05
                 EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  13 vtslafspdgawlasGsdDgtvriWd 38 
                 + +l++s+dg++l++Gs D+ v+++d
  EFC38233.1 445 IAALQYSHDGSLLVAGSHDNYVYVYD 470
                 56788***********99******98 PP

  == domain 9  score: 16.9 bits;  conditional E-value: 2.4e-06
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +++++l+GH s+v +++ s+d++++ s s D  + +Wd
  EFC38233.1 476 NLIGKLKGHsSFVKHIDISKDNQYIRSNSGDYEILLWD 513
                 57889****777************975444*******9 PP

  == domain 10  score: 4.2 bits;  conditional E-value: 0.025
                 SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  11 ssvtslafspdgawlasGsdDgtvriWd 38 
                 s+++s++++ ++++++ G+d++ v +++
  EFC38233.1 552 SDINSVDVDLSKKLVVVGTDNCQVSLYN 579
                 369****************9*9999987 PP

  == domain 11  score: 16.0 bits;  conditional E-value: 4.6e-06
                 EEESS.SSEEEEEEETTSSEEEEEETTSE CS
        WD40   6 tltGH.ssvtslafspdgawlasGsdDgt 33 
                 ++ GH s+vt+++fs +++ l++G+ D t
  EFC38233.1 591 SYIGHcSHVTAVKFSVNNKILSCGGGDLT 619
                 689**999*************99976865 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0     0.074   2.7e+02      25      67 ..      79     119 ..      72     125 .. 0.75
   2 !    5.3   0.0     0.007        25      33      89 ..     133     191 ..     127     194 .. 0.76
   3 ?    1.1   0.0      0.14   4.9e+02      34      75 ..     223     261 ..     189     274 .. 0.67
   4 ?    3.7   0.1     0.021        75      27      75 ..     298     347 ..     290     358 .. 0.77
   5 !    5.8   0.0    0.0048        17      48      81 ..     364     397 ..     349     405 .. 0.85
   6 !   30.3   0.0   1.1e-10     4e-07      10      71 ..     411     475 ..     402     533 .. 0.89
   7 ?   -2.7   0.0       2.1   7.4e+03      35      52 ..     519     536 ..     501     542 .. 0.74
   8 ?    4.1   0.1     0.016        58      25      67 ..     540     580 ..     535     607 .. 0.84
   9 ?   -0.4   0.0       0.4   1.4e+03      38      59 ..     596     617 ..     565     646 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.074
  ANAPC4_WD40  25 ngqrvwtleedkedsevrsLaWkpdgklLavay..sdgevrllda 67 
                  n q+v+     k+d  v +La +p+g+ +a +   +d  + + d+
   EFC38233.1  79 NTQKVFC----KHDDDVVALAKHPNGRYFASGQmgKDDMIYIWDS 119
                  5566664....59999**************986224556666665 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.007
  ANAPC4_WD40  33 eedkedsevrsLaWkpdgklLavaysd...gevrlldaesgkvvhslsvksekavtclgW 89 
                  +++ +++ v   +++ +g+lLa +      + + ++d ++g+++ +++ ++e+ v  l +
   EFC38233.1 133 NTQFKNGGVLTCCFSTEGSLLACVGGSpkmNIILIYDWNKGTCLANVKGTNEE-VYALCF 191
                  556678889999*********98664412278889999*******99988885.776665 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.14
  ANAPC4_WD40  34 edkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhs 75 
                   +++ ++v +++   +g+  +v+++dg++ ++  ++  +vh+
   EFC38233.1 223 PKGSIQNVYCICLDDNGNA-VVGVEDGSIYIFTGNN--IVHA 261
                  4566677888888888887.6899999999986554..4444 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.021
  ANAPC4_WD40  27 qrvwtleedkedsevrsLaWkpdgklLavaysdgev.rlldaesgkvvhs 75 
                  +++ ++++ + +s v+++a +++g +  v+ s+g + r+l+ ++ ++++ 
   EFC38233.1 298 NQITETSSVQVGSAVKNVASNESGDIVFVSKSNGDLeRILNKSTNTLISL 347
                  4566667788999*********************9834666555555544 PP

  == domain 5  score: 5.8 bits;  conditional E-value: 0.0048
  ANAPC4_WD40  48 pdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                  ++ +l+a a +dg+v + d e+ k +++++v+s 
   EFC38233.1 364 KNSSLFATASDDGRVIVWDTETRKHISQVRVTSL 397
                  67899***********************999875 PP

  == domain 6  score: 30.3 bits;  conditional E-value: 1.1e-10
  ANAPC4_WD40  10 iAlatedgellvfRlngqrvwtl...eedkedsevrsLaWkpdgklLavaysdgevrlldaesgk 71 
                  iA  t++g+l v R++ +++++    +++++ +e+ +L++++dg+lL+ + +d+ v ++d+++g 
   EFC38233.1 411 IATTTKEGSLFVLRFSKNKIFEDpivNRKDSIEEIAALQYSHDGSLLVAGSHDNYVYVYDVKKGY 475
                  8999******************98888999999*****************************995 PP

  == domain 7  score: -2.7 bits;  conditional E-value: 2.1
  ANAPC4_WD40  35 dkedsevrsLaWkpdgkl 52 
                  ++ + ++++++W+ ++  
   EFC38233.1 519 QSMNPNIEDIQWQTNNCT 536
                  555667888999888755 PP

  == domain 8  score: 4.1 bits;  conditional E-value: 0.016
  ANAPC4_WD40  25 ngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrllda 67 
                  n + +w+   d ++s ++s+    + kl +v++++ +v+l++ 
   EFC38233.1 540 NVRGIWKS--DMDGSDINSVDVDLSKKLVVVGTDNCQVSLYNY 580
                  56678888..8999**************************985 PP

  == domain 9  score: -0.4 bits;  conditional E-value: 0.4
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysd 59 
                   s+v++++++ ++k+L  +  d
   EFC38233.1 596 CSHVTAVKFSVNNKILSCGGGD 617
                  5679999999999999887766 PP

>> HELP  HELP motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.4   0.0   1.7e-11   6.1e-08      13      74 .]      15      76 ..       8      76 .. 0.87

  Alignments for each domain:
  == domain 1  score: 32.4 bits;  conditional E-value: 1.7e-11
        HELP 13 tlyiPsklenldakkkselPdekLkLewvyGYrgkdcrnnlfll.ptgeivYfvAavvvlynv 74
                t ++P  +++  ++++ e+P  kLk+e+++G+  k c  n+f + +++ +vY +A+ +v++nv
  EFC38233.1 15 TTHPPP-NSSGLMESNPEKPLSKLKIEYIHGCSKKGCYGNVFHVdDEQHLVYPAAGCGVVLNV 76
                556665.4677779999*************************9978999************96 PP

>> Reg_prop  Two component regulator propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.1   3.8e+03       4      18 ..      88     102 ..      86     106 .. 0.83
   2 !    5.5   0.0    0.0074        27       4      24 .]     183     204 ..     180     204 .. 0.82
   3 !    7.2   0.1     0.002         7       5      21 ..     228     244 ..     224     255 .. 0.87
   4 ?    0.1   0.0      0.41   1.5e+03       7      23 ..     445     461 ..     441     462 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.1
                 SSCEEEEEE-TTSCE CS
    Reg_prop   4 snnvtaileDsdGrl 18 
                 +++v a+++ ++Gr 
  EFC38233.1  88 DDDVVALAKHPNGRY 102
                 67899********86 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0074
                 SSCEEEEEE-TTS.CEEEEESS CS
    Reg_prop   4 snnvtaileDsdG.rlWvGteg 24 
                 +++v+a++  +d  +l++++++
  EFC38233.1 183 NEEVYALCFSKDDnNLYLCGKN 204
                 789**9999777779***9975 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.002
                 SCEEEEEE-TTSCEEEE CS
    Reg_prop   5 nnvtaileDsdGrlWvG 21 
                 +nv++i+ D +G+  vG
  EFC38233.1 228 QNVYCICLDDNGNAVVG 244
                 79**********96665 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.41
                 EEEEEE-TTSCEEEEES CS
    Reg_prop   7 vtaileDsdGrlWvGte 23 
                 + a+++ +dG l v+++
  EFC38233.1 445 IAALQYSHDGSLLVAGS 461
                 669999******99986 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1     0.033   1.2e+02      20      35 ..     237     252 ..     226     257 .. 0.88
   2 ?   -1.6   0.0       1.2   4.4e+03      19      32 ..     319     332 ..     292     333 .. 0.59
   3 ?    1.0   0.0      0.18   6.6e+02      26      40 .]     371     385 ..     358     385 .. 0.75
   4 ?    5.8   0.4    0.0057        20      20      38 ..     453     471 ..     446     472 .. 0.91
   5 ?   -0.9   0.0      0.75   2.7e+03       5      30 ..     545     572 ..     527     576 .. 0.61

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.033
       PQQ_3  20 dgglvyvgtgdGtlyA 35 
                 d+g  +vg +dG++y 
  EFC38233.1 237 DNGNAVVGVEDGSIYI 252
                 57999********995 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.2
       PQQ_3  19 vdgglvyvgtgdGt 32 
                  +g++v+v+ ++G 
  EFC38233.1 319 ESGDIVFVSKSNGD 332
                 25999999877775 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.18
       PQQ_3  26 vgtgdGtlyAlDaet 40 
                 ++++dG++   D+et
  EFC38233.1 371 TASDDGRVIVWDTET 385
                 345599999999887 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0057
       PQQ_3  20 dgglvyvgtgdGtlyAlDa 38 
                 dg l+++g++d+ +y +D 
  EFC38233.1 453 DGSLLVAGSHDNYVYVYDV 471
                 7889*************96 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 0.75
       PQQ_3   5 Wsvqlpg.pvnssp..avdgglvyvgtgd 30 
                 W+ + +g ++n s+   ++  lv+vgt++
  EFC38233.1 545 WKSDMDGsDIN-SVdvDLSKKLVVVGTDN 572
                 55555443553.44333446678888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (684 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       466  (0.0259914); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 4181.67
//
Query:       EFC38234.1  [L=638]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.2e-20   71.4  39.7    5.2e-12   46.1  19.5    3.2  2  EamA          EamA-like transporter family
  ------ inclusion threshold ------
       0.37   11.0   5.5          4    7.6   0.9    4.0  3  YtpI          YtpI-like protein
       0.67   10.1   3.2        6.3    6.9   0.0    3.2  3  TssO          Type VI secretion system, TssO
        3.2    7.0  19.8      0.073   12.4   6.7    2.8  3  Peptidase_U4  Sporulation factor SpoIIGA


Domain annotation for each model (and alignments):
>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5  12.2   4.5e-08    0.0002       3     136 ..     224     405 ..     222     406 .. 0.89
   2 !   46.1  19.5   1.2e-15   5.2e-12       2     136 ..     456     592 ..     455     593 .. 0.92

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 4.5e-08
        EamA   3 gillallaalfwaiyfvlskillrkvspltltfvrfliagilllii...........................................allkegkl.. 56 
                 + +l++   ++++  ++ls ++++ + p+ + ++r  i  i ++++                                           +l+ ++++  
  EFC38234.1 224 PHILLISNLVLFGGFYLLSPHAMKIFRPIIFGVFRVGIMIICMFPVmlyfdrsysfrnekklrrrkeeysilvsskrdsllyyyyqanyYLFYANPIvd 322
                 678999999**********************************99999****************************************85555555566 PP

        EamA  57 ....aklslkdwllllllgllgtvlafllffyalkktsasnaslitslePvftlilsvlllgekltlkqllgivlillGvllil 136
                     + +++k+ + l   g + ++l ++ f+++   t+a++ s ++  + v+t ils+ll +e+ ++++l+g++ +++G++ ++
  EFC38234.1 323 yalrKIPKWKQTKTLTWCG-IFIILNQITFLTGYYLTNATVSSSLSPCTSVITCILSMLLGREPKSILKLVGVITSVMGAIAMI 405
                 6666666777777766666.578899*****************************************************99765 PP

  == domain 2  score: 46.1 bits;  conditional E-value: 1.2e-15
        EamA   2 lgillallaalfwaiyfvlskill.rkvspltltfvrfliagilllii.allkegklaklslkdwllllllgllgtvlafllffyalkktsasnaslit 98 
                 lg+l++ll++l+ ++y +++k+ll ++v+p+t+tf++f+ +  +ll++ +++  ++++k +l +   l++ gl  +++ f+++++a + +++++++l++
  EFC38234.1 456 LGLLFLLLSTLVNSLYLLTQKKLLnNNVPPITVTFWSFFYGYGVLLFVgCFFLPINFSKVDLMSAVGLIYAGLPFGAVQFIFQTKASSMSTPTIVGLYS 554
                 699*****************88861567***********8876666664888888889***************************************** PP

        EamA  99 slePvftlilsvlllgekltlkqllgivlillGvllil 136
                 +++P++ li +  +lgek + + +lg ++i++Gv++++
  EFC38234.1 555 TMSPMVGLITGLTFLGEKTSPFVVLGGIFIIMGVIIVI 592
                 ***********************************997 PP

>> YtpI  YtpI-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1      0.12   5.4e+02       2      28 ..     261     288 ..     260     291 .. 0.89
   2 ?    1.2   0.0     0.091   4.1e+02      28      51 ..     330     353 ..     308     366 .. 0.76
   3 ?    7.6   0.9    0.0009         4      38      83 ..     556     601 ..     530     605 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.12
        YtpI   2 ilivlslvlyvyykvka.frtkdplekk 28 
                 i+i++ + +++y+ + + fr +++l+++
  EFC38234.1 261 IMIICMFPVMLYFDRSYsFRNEKKLRRR 288
                 6899999999***999999**9999986 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.091
        YtpI  28 kllsakasialGlflilfginqll 51 
                 k+ ++k   + G+f+il  i +l 
  EFC38234.1 330 KWKQTKTLTWCGIFIILNQITFLT 353
                 799999999999999987666554 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0009
        YtpI  38 lGlflilfginqllllestvalvvgavflvlGlanlfaGiraykhy 83 
                 ++ ++ l+    +l  ++   +v g +f+++G++ ++ +  + +h+
  EFC38234.1 556 MSPMVGLITGLTFLGEKTSPFVVLGGIFIIMGVIIVIVARYKETHI 601
                 5667777777888999999999***********9998876666665 PP

>> TssO  Type VI secretion system, TssO
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.3       1.3   5.7e+03     114     139 ..       6      31 ..       4      38 .. 0.79
   2 ?    2.0   0.1     0.046     2e+02      20      52 ..     261     294 ..     252     302 .. 0.58
   3 ?    6.9   0.0    0.0014       6.3       5      48 ..     571     613 ..     570     631 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.3
        TssO 114 akfykmlledKkelksvseniklfkk 139
                 + +y++  + +++  s+++n ++++k
  EFC38234.1   6 HHHYESNPKKRRRKNSKKKNHQEYNK 31 
                 56777778888888888888888887 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.046
        TssO  20 tvlllflivffffk.ssplqekeillkelerkkk 52 
                 +++++++ v ++f  s+ + ++++l+ + e+++ 
  EFC38234.1 261 IMIICMFPVMLYFDrSYSFRNEKKLRRRKEEYSI 294
                 4555555555555505666666666666666654 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0014
        TssO   5 ErrsgflyflllFlvtvlllflivffffkssplqekeil.lkele 48 
                 E++s f+ + ++F+++ ++++  +  ++k+++++++e+l   + e
  EFC38234.1 571 EKTSPFVVLGGIFIIMGVIIV--IVARYKETHIKKQEELhNTDSE 613
                 89999*******998877777..8999999*******99555544 PP

>> Peptidase_U4  Sporulation factor SpoIIGA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.3    0.0085        38      81     154 ..     217     298 ..     207     305 .. 0.66
   2 ?   -1.2   0.7      0.23     1e+03      22      73 ..     377     405 ..     320     425 .. 0.53
   3 ?   12.4   6.7   1.6e-05     0.073       7     145 ..     460     605 ..     459     611 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.0085
  Peptidase_U4  81 slkeflkalllfylvsfllgGilfalsyll..lkskn........llvlllgalvaylllkllvkii.kkkkkkekeiyeveiel 154
                   s+ + l   +l++   +l+gG++++   ++  +            + +++++++ ++l++ + +++  +kk++++ke y + ++ 
    EFC38234.1 217 SIYKALLPHILLISNLVLFGGFYLLSPHAMkiF---RpiifgvfrVGIMIICMFPVMLYFDRSYSFRnEKKLRRRKEEYSILVSS 298
                   444444445566666788899888777755441...2455666667777777777777777777777678888888888887765 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.23
  Peptidase_U4  22 takllklkikklrlllaAllGalyvvlvlflpklesillsillkilvsllmv 73 
                    + ll++++k +                         l+ +++ ++ +++m+
    EFC38234.1 377 LSMLLGREPKSILK-----------------------LVGVITSVMGAIAMI 405
                   22222222222211.......................122222222222222 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 1.6e-05
  Peptidase_U4   7 lflvNllmdyllLlltakllklkikklrlllaAll...Galyvvlvlflp....klesillsillkilvsllmvliafgpkslkeflkalllfylvs 96 
                   ++l+  l++ l Ll+ +kll+ ++ ++ + +++++   G l+ v ++flp    k   + +  l+++ +++  v + f++k  +    +++ +y + 
    EFC38234.1 460 FLLLSTLVNSLYLLTQKKLLNNNVPPITVTFWSFFygyGVLLFVGCFFLPinfsKVDLMSAVGLIYAGLPFGAVQFIFQTKASSMSTPTIVGLYSTM 556
                   678999****************************94445555555788886554444344444566677777785559****9999*********** PP

  Peptidase_U4  97 fllgGilfalsylllksknllvlllgalvaylllk.llvkiikkkkkkek 145
                     + G++++l + l ++++  v+l g+++++ ++  +++++ ++++kk++
    EFC38234.1 557 SPMVGLITGLTF-LGEKTSPFVVLGGIFIIMGVIIvIVARYKETHIKKQE 605
                   ************.6544444555555555555555155555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (638 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1486  (0.0828825); expected 358.6 (0.02)
Passed bias filter:                      606  (0.0338); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.80u 0.32s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 3621.09
//
Query:       EFC38235.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       783  (0.0436723); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 2261.78
//
Query:       EFC38236.1  [L=381]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.6e-06   28.5   0.0    3.6e-06   27.4   0.0    1.6  2  PhyH            Phytanoyl-CoA dioxygenase (PhyH)
  ------ inclusion threshold ------
      0.025   15.0   0.0      0.067   13.6   0.0    1.7  1  2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase


Domain annotation for each model (and alignments):
>> PhyH  Phytanoyl-CoA dioxygenase (PhyH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.52   4.7e+03       5      26 ..      65      83 ..      61     175 .. 0.59
   2 !   27.4   0.0     4e-10   3.6e-06     129     210 ..     244     331 ..     215     332 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.52
                SEEEETTSS-HHHHHHHHHHHH CS
        PhyH  5 Gylviegflsaeevealraeie 26
                G++v  + l++e++   ++ i 
  EFC38236.1 65 GFVVFNSILNQEQI---NNSIS 83
                66666666666333...22222 PP

  == domain 2  score: 27.4 bits;  conditional E-value: 4e-10
                 EESS-B-TTBT-EEEETTGGGS-CCGTCCHHCSGCCTTS.........CCCTTTGHGSCEEEE.BTTTEEEEEETTSEEEE-TB.SSSXEE CS
        PhyH 129 ialedateenGclrfiPGSHkweegplrrrlpeddteae.........ddeakkedeeeavpvevkaGdavlfhgrllHgsgaNrsdksRr 210
                 i + d  ++ G+  ++P   k   + + ++l++  t a+            ++ke  ++av +++kaGd ++++    Hgs++N sd+ R 
  EFC38236.1 244 INFVDNRAQDGGFIIVPKFNKI--FKEWTQLTRN-TLANkyvdssfvvLSRQEKELFNKAVRIPLKAGDMLIWDICMPHGSAPNESDRYRL 331
                 5666777777777777777777..4333333333.333347777788777888888999****************************9995 PP

>> 2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   7.5e-06     0.067      56      97 ..     291     332 ..     267     334 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 7.5e-06
  2OG-FeII_Oxy_5  56 eeakeenqslvdvkpkeGdlvlFPswlrHevlpnegeeeRis 97 
                      ++ke  +++v +  k+Gd++++   + H+  pne+++ R++
      EFC38236.1 291 RQEKELFNKAVRIPLKAGDMLIWDICMPHGSAPNESDRYRLC 332
                     356678899*******************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       563  (0.0314016); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.22s 00:00:00.74 Elapsed: 00:00:00.41
# Mc/sec: 2815.15
//
Query:       EFC38237.1  [L=813]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1640  (0.0914719); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.81u 0.36s 00:00:01.17 Elapsed: 00:00:00.54
# Mc/sec: 4535.50
//
Query:       EFC38238.1  [L=513]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.6e-68  229.2   0.5    1.9e-67  227.4   0.0    1.9  2  Pkinase      Protein kinase domain
    1.1e-53  182.2   0.0    3.1e-53  180.7   0.0    1.7  2  Pkinase_Tyr  Protein tyrosine kinase
     0.0011   18.3   0.4     0.0026   17.1   0.0    1.8  2  Kinase-like  Kinase-like
  ------ inclusion threshold ------
      0.039   13.9   0.0       0.12   12.3   0.0    1.7  2  APH          Phosphotransferase enzyme family
       0.12   12.2   9.3       0.36   10.7   9.3    1.7  1  Med19        Mediator of RNA pol II transcription subunit 19


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   1.0      0.29   1.1e+03      46      99 ..      86     138 ..      58     184 .. 0.68
   2 !  227.4   0.0   5.4e-71   1.9e-67       3     264 .]     226     483 ..     224     483 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.29
                 HHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHH CS
     Pkinase  46 lrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseee 99 
                  +E  ++k+ + +n v +  v+ee+++++l++e  e++  ++++ ++ ++ eee
  EFC38238.1  86 KKEAGMMKQRQRRNSVDM-PVVEEEEDMVLMNEDEEKNPSEEVIAEQLTFMEEE 138
                 556667777777776665.45566666777777777777777777666655542 PP

  == domain 2  score: 227.4 bits;  conditional E-value: 5.4e-71
                 EEEEEEEESSEEEEEEE....ETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHHHHSS- CS
     Pkinase   3 kleklGeGsfGkVykav....eketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladllerkgsl 95 
                  +e lG G+ GkVyk++     ++t++ vA+Kk++++  + +k k +  E+ ilk+l hp++v+++++ ++   +e+ +vleyv+gg+l+++++++g +
  EFC38238.1 226 LDELLGIGAHGKVYKGFipnyITNTKDPVAIKKLSVKAGRFSK-KFIKLEVDILKQLYHPYLVQYLGCKYSskLKEYSIVLEYVDGGTLEHFIKTSGPM 323
                 6789***********9622224799**********99888776.58999*****************998874467999********************* PP

                 -HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHS CS
     Pkinase  96 seeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltg 193
                 +e++++ +++q+l gleylHsk+iiHrDlKp+NiLi+ kg++KitDFG++++l + +   ts vgt++Y APEv+  ++ys ++D+WslG++++ell+g
  EFC38238.1 324 DERTVSVVVSQVLMGLEYLHSKRIIHRDLKPANILISGKGVVKITDFGVSAQLLNIEAiRTSCVGTPHYSAPEVIMVKPYSFTADIWSLGCVVFELLFG 422
                 ***************************************************99998888999************************************* PP

                 S-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 194 kppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 k p+           e++q+ ++++++++ k  +p+++++s+ ++d+++k+++kd kkR+ta+el  hp++
  EFC38238.1 423 KRPYD----------EFNQVAAMYHMVKDDKPPMPTPNNLSPVCLDFIDKCWTKDWKKRPTARELQTHPFV 483
                 *****..........56666666777777899*************************************96 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1      0.54   1.9e+03      44      78 ..      81     114 ..      72     157 .. 0.62
   2 !  180.7   0.0   8.5e-57   3.1e-53       1     256 [.     224     478 ..     224     480 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.54
                  HHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEE CS
  Pkinase_Tyr  44 ekeelleeakimkklkhpnivkllgvctkeeplli 78 
                   + +  +ea +mk+ + +n v +  v  +ee +++
   EFC38238.1  81 GTIDWKKEAGMMKQRQRRNSVDMPVV-EEEEDMVL 114
                  55667778888888877777776433.33333333 PP

  == domain 2  score: 180.7 bits;  conditional E-value: 8.5e-57
                  EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHH.HHHHHHTS-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelle.eakimkklkhpnivkllgvct..keepllivteyvkgGdLlkfLrkk 95 
                  +el++ lG Ga GkV++g + +  ++++  Va+K+l+ +a + + +++++ e++i+k+l hp +v++lg+ +  k +++ iv+eyv+gG+L++f++++
   EFC38238.1 224 IELDELLGIGAHGKVYKGFIPNYITNTKDPVAIKKLSVKAGRFS-KKFIKlEVDILKQLYHPYLVQYLGCKYssKLKEYSIVLEYVDGGTLEHFIKTS 320
                  578999******************************99999985.555555*******************99666678******************98 PP

                  CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHH CS
  Pkinase_Tyr  96 ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGv 193
                     +++ +++  ++ qv  G+eyL+sk+++Hrdl   N+L+s + vvki+DfG++ ++ + +    ++++    ++ apE+++ k ++  +D+Ws G 
   EFC38238.1 321 --GPMDERTVSVVVSQVLMGLEYLHSKRIIHRDLKPANILISGKGVVKITDFGVSAQLLNIE--AIRTSCVGTPHYSAPEVIMVKPYSFTADIWSLGC 414
                  ..99******************************************************5555..4568889999************************ PP

                  HHHHHHTTSSGTTTTS.HHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 194 llwEiftlgespypgl.kneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRptfselv 256
                  +++E++  g++py ++ + + +++++ +++  +++p++ ++   +++ kcw++d ++Rpt +el+
   EFC38238.1 415 VVFELLF-GKRPYDEFnQVAAMYHMVkDDKPPMPTPNNLSPVCLDFIDKCWTKDWKKRPTARELQ 478
                  *****98.********7778899999444556****************************99987 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.4       1.1   4.1e+03      11      57 ..      96     146 ..      92     167 .. 0.51
   2 !   17.1   0.0   7.3e-07    0.0026     158     253 ..     340     429 ..     319     448 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.1
  Kinase-like  11 ertlvrgellkkgdrsvvfevkdqetgeplav..kvfllps..easkkdle 57 
                  +r   +  ++ ++++ +v+  +d+e++ + +v   + ++ +   + + d +
   EFC38238.1  96 QRRNSVDMPVVEEEEDMVLMNEDEEKNPSEEViaEQLTFMEeeTPTNTDKQ 146
                  444444455555566666667777766444442234443331133333333 PP

  == domain 2  score: 17.1 bits;  conditional E-value: 7.3e-07
  Kinase-like 158 anLqakglvhgkftvdnllldekgglmlggftaLvragtkvvl..seve.kgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwclklPltl 252
                   +L++k ++h ++++ n+l   kg +++++f+   +  +   +  s v    ++ pE++             +++  d W lG v++ +   k P ++
   EFC38238.1 340 EYLHSKRIIHRDLKPANILISGKGVVKITDFGVSAQLLNIEAIrtSCVGtPHYSAPEVIMV---------KPYSFTADIWSLGCVVFELLFGKRPYDE 428
                  69****************************9854444333333116665467899999987.........358999***********99888888776 PP

  Kinase-like 253 a 253
                   
   EFC38238.1 429 F 429
                  5 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       0.7   2.5e+03      60      85 ..     291     318 ..     245     344 .. 0.70
   2 ?   12.3   0.0   3.3e-05      0.12     165     193 ..     344     370 ..     331     373 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.7
                 TBS-EEETTEEEEEEE----EE-SS..H CS
         APH  60 gdtddeeigllfalieyvpgrsllr..k 85 
                 g++    +  ++ ++eyv+g +l++  k
  EFC38238.1 291 GCKYSSKLKEYSIVLEYVDGGTLEHfiK 318
                 3555555555788999999999988661 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 3.3e-05
                 -EEEE-SS-SGGGEEEC..TTEEEEE--- CS
         APH 165 ptvllHgDlhpgNllvdpddgrvtGviDf 193
                 +++++H+Dl+p N+l+  ++g v  + Df
  EFC38238.1 344 SKRIIHRDLKPANILIS-GKGVV-KITDF 370
                 689**************.66665.55555 PP

>> Med19  Mediator of RNA pol II transcription subunit 19
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   9.3    0.0001      0.36      97     168 ..     128     195 ..     124     205 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0001
       Med19  97 lpeqyrllkkqePkkknkekhkkskvkdakseetlsdseteegfekkhkkkkkedDkerkkkkkekkkkkkr 168
                 + eq  +++++ P++  k+k++ ++  ++ ++e    +   ++ +kk+kkk k++D++r +  + ++++++ 
  EFC38238.1 128 IAEQLTFMEEETPTNTDKQKFQFNQLLQHLNSEVEYSD---KT-KKKKKKKHKNKDHDRIQSPRVRENREES 195
                 789*************9*99998888776655544444...23.3333333468888887665555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (513 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2041  (0.113838); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 2997.87
//
Query:       EFC38239.1  [L=784]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-14   52.7   1.9       0.12   12.4   0.0    7.5  7  Arm       Armadillo/beta-catenin-like repeat
    0.00083   19.8   0.0       0.73   10.4   0.0    3.5  3  HEAT_EZ   HEAT-like repeat
     0.0046   17.2   0.6        1.1    9.6   0.0    3.8  4  RICTOR_V  Rapamycin-insensitive companion of mTOR, domain 5
  ------ inclusion threshold ------
      0.035   14.0   0.0       0.19   11.6   0.0    2.4  1  GRAB      GRIP-related Arf-binding domain
       0.15   12.4   0.1         27    5.4   0.0    3.9  3  HEAT      HEAT repeat


Domain annotation for each model (and alignments):
>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0       0.1   3.6e+02       5      22 ..     366     383 ..     363     398 .. 0.82
   2 !    4.6   0.1    0.0096        34      16      40 ..     445     469 ..     433     470 .. 0.88
   3 !    7.5   0.1    0.0012       4.3       4      40 ..     475     520 ..     472     521 .. 0.84
   4 !    6.6   0.0    0.0023       8.3      20      39 ..     541     560 ..     535     561 .. 0.87
   5 !   10.4   0.0   0.00014      0.52      14      41 .]     576     603 ..     563     603 .. 0.86
   6 ?   -0.8   0.0      0.49   1.8e+03       2      30 ..     606     634 ..     605     635 .. 0.85
   7 !   12.4   0.0   3.4e-05      0.12       2      38 ..     649     687 ..     648     687 .. 0.94

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.1
                 HHHHHHTTHHHHHHHHTT CS
         Arm   5 kdavieaGavppLvrLLs 22 
                 +d v e+ +v+ L++ L+
  EFC38239.1 366 IDSVLESDCVQTLISYLD 383
                 7899**********9998 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0096
                 HHHHHTTTSSHHHHHHHHHHHHHHT CS
         Arm  16 pLvrLLssedeevqeeAawALsNLa 40 
                  L+ L++s+ ++++ eA+w  +NLa
  EFC38239.1 445 KLILLINSMCDSIRYEALWICGNLA 469
                 68999**************877776 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0012
                 HHHHHHHTTHHHHHHHHTT.........TSSHHHHHHHHHHHHHHT CS
         Arm   4 nkdavieaGavppLvrLLs.........sedeevqeeAawALsNLa 40 
                 ++d + +++++   v+L++          + +++++ Aaw+ s L+
  EFC38239.1 475 FRDDLLDSNVLNEIVTLITgfsgttdlnEDTTSLLRMAAWCFSKLC 520
                 678888888888888888888888888888999**********999 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0023
                 HTTTSSHHHHHHHHHHHHHH CS
         Arm  20 LLssedeevqeeAawALsNL 39 
                 +Ls ed ++++++++AL+ L
  EFC38239.1 541 FLSFEDSDILKNVCRALGRL 560
                 67899************977 PP

  == domain 5  score: 10.4 bits;  conditional E-value: 0.00014
                 HHHHHHHTTTSSHHHHHHHHHHHHHHTT CS
         Arm  14 vppLvrLLssedeevqeeAawALsNLaa 41 
                 +p  v+LL++ d++v  +A+ A  N++a
  EFC38239.1 576 LPKIVDLLKHVDDNVIGQALVAAVNISA 603
                 899**********************996 PP

  == domain 6  score: -0.8 bits;  conditional E-value: 0.49
                 HHHHHHHHHTTHHHHHHHHTTTSSHHHHH CS
         Arm   2 senkdavieaGavppLvrLLssedeevqe 30 
                 +e +++++ ++a+ +  + L+s + ++ +
  EFC38239.1 606 DEETQELVTLNALNVCYDILKSNKSRTIK 634
                 667899999************99988765 PP

  == domain 7  score: 12.4 bits;  conditional E-value: 3.4e-05
                 HHHHHHHHHTTHHHHHHHHTT..TSSHHHHHHHHHHHHH CS
         Arm   2 senkdavieaGavppLvrLLs..sedeevqeeAawALsN 38 
                 +++ ++ +e+G+++   +L +  +++ ++++eA+w  sN
  EFC38239.1 649 EKQVECAVECGVLELVANLFHnrDTHIDMKKEAVWIFSN 687
                 5799999****************************9998 PP

>> HEAT_EZ  HEAT-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.018        64      30      55 .]     443     468 ..     418     468 .. 0.78
   2 !   10.4   0.0    0.0002      0.73       5      55 .]     510     560 ..     506     560 .. 0.79
   3 ?    0.5   0.0      0.26   9.2e+02      16      54 ..     646     687 ..     637     726 .. 0.65

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.018
     HEAT_EZ  30 lpaLlalLnddsdeVRaaAagaLgnl 55 
                 +  L+ l n+ +d++R+ A++ +gnl
  EFC38239.1 443 ITKLILLINSMCDSIRYEALWICGNL 468
                 78899999****************97 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.0002
     HEAT_EZ   5 raAawaLGr....laggepellqplvpeilpaLlalLnddsdeVRaaAagaLgnl 55 
                 r Aaw+++       +   +    +  + + +L ++L+ +++++ +++++aLg+l
  EFC38239.1 510 RMAAWCFSKlcfgTVFPKER----HMRKEIELLDKFLSFEDSDILKNVCRALGRL 560
                 77999998644444444445....55599************************97 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.26
     HEAT_EZ  16 ggepellqplvpeilpaLlalLnddsd.eV..RaaAagaLgn 54 
                 ++   +++++v+  + +L+a L +  d ++  ++ A++ ++n
  EFC38239.1 646 ACTEKQVECAVECGVLELVANLFHNRDtHIdmKKEAVWIFSN 687
                 555555555555556666666666666555556666666554 PP

>> RICTOR_V  Rapamycin-insensitive companion of mTOR, domain 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.9   6.8e+03      24      43 ..     156     175 ..     150     177 .. 0.78
   2 !    9.6   0.0    0.0003       1.1       6      37 ..     461     493 ..     458     498 .. 0.89
   3 ?   -1.5   0.0      0.88   3.1e+03       6      38 ..     637     670 ..     635     673 .. 0.81
   4 ?    2.8   0.0     0.038   1.4e+02       3      40 ..     678     718 ..     676     725 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.9
    RICTOR_V  24 deydivedivelaeespvls 43 
                 d+ +iv++i +++ es+ + 
  EFC38239.1 156 DSVNIVNSIQKIMDESEPCM 175
                 45699999*99999998665 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0003
    RICTOR_V   6 aLWaiGhigsselGie..lldeydivedivelae 37 
                 aLW++G+ +++++ ++  lld+ +++++iv l++
  EFC38239.1 461 ALWICGNLAKHHHNFRddLLDS-NVLNEIVTLIT 493
                 9**************9988888.9*****99876 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.88
    RICTOR_V   6 aLWaiGhigs.selGielldeydivedivelaee 38 
                 a+  + +i++ +e+ +e   e+ ++e +++l+++
  EFC38239.1 637 AMILVSNIAAcTEKQVECAVECGVLELVANLFHN 670
                 6778889988678888888888999999999887 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.038
    RICTOR_V   3 lKaaLWaiGhigs..selGie.lldeydivedivelaeesp 40 
                 +K a W++ +  s  +e+ +e + ++y+i+  +++++++++
  EFC38239.1 678 KKEAVWIFSNSTSngTEQHLElFTEKYQILVPVAKMVMNCN 718
                 6999******99988899999888899**********9996 PP

>> GRAB  GRIP-related Arf-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   5.3e-05      0.19       1      14 [.       8      21 ..       8      21 .. 0.95

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.3e-05
        GRAB  1 sseenVDKrLISNL 14
                ++ee+ DK+++SNL
  EFC38239.1  8 QPEETFDKQIVSNL 21
                79***********8 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0    0.0077        27       8      31 .]     449     472 ..     444     472 .. 0.85
   2 ?    0.4   0.0       0.3   1.1e+03      19      29 ..     511     521 ..     503     523 .. 0.87
   3 ?    0.6   0.0      0.26   9.3e+02      12      28 ..     545     561 ..     536     562 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0077
                 HHT-SSHHHHHHHHHHHHHHHHCS CS
        HEAT   8 llsDpspeVReaAakaLgalaevl 31 
                 l+++ + ++R+ A++ +g+la+++
  EFC38239.1 449 LINSMCDSIRYEALWICGNLAKHH 472
                 45888999*************985 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.3
                 HHHHHHHHHHH CS
        HEAT  19 aAakaLgalae 29 
                 +Aa+++ +l+ 
  EFC38239.1 511 MAAWCFSKLCF 521
                 79******996 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.26
                 SSHHHHHHHHHHHHHHH CS
        HEAT  12 pspeVReaAakaLgala 28 
                 +++++ +++++aLg+l+
  EFC38239.1 545 EDSDILKNVCRALGRLM 561
                 57778899******996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (784 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1000  (0.0557756); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 4637.30
//
Query:       EFC38240.1  [L=724]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      3e-12   46.6   0.7    7.9e-12   45.3   0.7    1.8  1  Cauli_VI         Caulimovirus viroplasmin
    8.1e-11   41.9   0.2    1.5e-10   41.1   0.2    1.5  1  Myb_DNA-binding  Myb-like DNA-binding domain
    1.8e-06   27.6   8.3    3.5e-06   26.7   8.3    1.5  1  zf-CCCH_4        CCCH-type zinc finger
    0.00026   20.8   5.4    0.00026   20.8   5.4    1.8  2  zf-CCCH          Zinc finger C-x8-C-x5-C-x3-H type (and simil
  ------ inclusion threshold ------
      0.056   13.5   8.3       0.14   12.3   8.3    1.7  1  zf_CCCH_4        Zinc finger domain
       0.13   12.3   0.1       0.27   11.3   0.1    1.5  1  PP1              Phloem filament protein PP1 cystatin-like do
       0.26   11.8   6.8       0.73   10.4   6.8    1.8  1  zf-CCCH_2        RNA-binding, Nab2-type zinc finger
       0.48   11.1   6.8       0.18   12.5   0.8    3.1  2  Torus            Torus domain


Domain annotation for each model (and alignments):
>> Cauli_VI  Caulimovirus viroplasmin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.3   0.7   3.5e-15   7.9e-12       6      38 ..     573     605 ..     573     611 .. 0.93

  Alignments for each domain:
  == domain 1  score: 45.3 bits;  conditional E-value: 3.5e-15
    Cauli_VI   6 akGrepgiYttWdecqkqvkgfpgakyKsFktr 38 
                 +kGr+pg+Y  Wd+c++qv+gf+g +yK+F++ 
  EFC38240.1 573 KKGRNPGVYLKWDDCKEQVQGFSGNCYKKFSSI 605
                 69*****************************97 PP

>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.1   0.2   6.8e-14   1.5e-10       2      46 .]     521     567 ..     520     567 .. 0.96

  Alignments for each domain:
  == domain 1  score: 41.1 bits;  conditional E-value: 6.8e-14
                      SSSBHHHHHHHHHHHHHHT.TCHHHHHHHHT.SS-HHHHHHHHHHHT CS
  Myb_DNA-binding   2 gkWteeEdelLleavkkhG.nrWkkIaerlg.gRtekqcrsrwrnyl 46 
                      g+Wte E+  + +++++ G +rW++Iae +  +Rt+ q+ s+ r+yl
       EFC38240.1 521 GAWTEKEHADFMRGLNECGrGRWREIAENYVlTRTRTQVASHARKYL 567
                      89**************************8888**************7 PP

>> zf-CCCH_4  CCCH-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   8.3   1.6e-09   3.5e-06       1      22 []     680     701 ..     680     701 .. 0.96

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 1.6e-09
   zf-CCCH_4   1 rlCpyfakGsCrfGdnCrFsHd 22 
                 ++C+y ++G+CrfG nCrF+H+
  EFC38240.1 680 PVCRYHLEGNCRFGRNCRFYHP 701
                 69*******************7 PP

>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       3.9   8.8e+03       9      18 ..     531     541 ..     530     541 .. 0.81
   2 !   20.8   5.4   1.2e-07   0.00026       4      27 .]     680     702 ..     679     702 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.9
                 HHHHS..--TTG CS
     zf-CCCH   9 fmrtG..yCkyG 18 
                 fmr G  +C +G
  EFC38240.1 531 FMR-GlnECGRG 541
                 889.88899998 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 1.2e-07
                 HCBCHHHHHS--TTGGG-SSBSCS CS
     zf-CCCH   4 elCrffmrtGyCkyGdrCkFaHgq 27 
                 + Cr++++ G C++G +C+F H++
  EFC38240.1 680 PVCRYHLE-GNCRFGRNCRFYHPP 702
                 68******.*************96 PP

>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   8.3   6.2e-05      0.14       1      17 [.     682     698 ..     682     700 .. 0.96

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.2e-05
   zf_CCCH_4   1 CkfflqGtCkkGdkCrF 17 
                 C++ l+G+C++G +CrF
  EFC38240.1 682 CRYHLEGNCRFGRNCRF 698
                 ****************9 PP

>> PP1  Phloem filament protein PP1 cystatin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   0.00012      0.27      18      54 ..     595     633 ..     587     645 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00012
         PP1  18 sGdsL.kfee.iyeGWylelgqdnlkfRlhvkakDfLgR 54 
                 sG++  kf++ i+  W++e g++  k R+  + kD+++ 
  EFC38240.1 595 SGNCYkKFSSiIFADWFVEEGPKKFKKRIRFHSKDWVSS 633
                 5777625764279***********************975 PP

>> zf-CCCH_2  RNA-binding, Nab2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   6.8   0.00032      0.73       2      18 .]     682     701 ..     682     701 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00032
   zf-CCCH_2   2 Crffpn..C.tnpkCpFaHP 18 
                 Cr+     C ++ +C+F+HP
  EFC38240.1 682 CRYHLEgnCrFGRNCRFYHP 701
                 88888888***********9 PP

>> Torus  Torus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.6      0.89     2e+03      22      60 ..     381     416 ..     359     429 .. 0.41
   2 ?   12.5   0.8   8.1e-05      0.18      57      91 ..     667     700 ..     620     712 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.89
                 SS-----.TTSS----S-THHHHS-----S----HHHH-- CS
       Torus  22 qegeeyN.iWynkwsgeekekkkkskekaktrcnikkdsG 60 
                 + ++ +N i+y+   +++++     +++++   + +k++ 
  EFC38240.1 381 HLNTIFNgIFYEDAENSKRKI----EDASNSSRKKRKNEN 416
                 333455545555333221111....111111112222222 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 8.1e-05
                 HH----HHHHSTT--B-HHHHHT--SSGGG-SSB- CS
       Torus  57 kdsGytkadkekesyfClfFarGlCakGkkCeylH 91 
                 k+ G  +a++ +++ +C ++  G C  G++C+++H
  EFC38240.1 667 KNIGD-EANDCSHAPVCRYHLEGNCRFGRNCRFYH 700
                 44443.455677899******************** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (724 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1615  (0.0900775); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.73u 0.32s 00:00:01.05 Elapsed: 00:00:00.49
# Mc/sec: 4399.72
//
Query:       EFC38241.1  [L=411]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.2e-39  133.5   0.2      1e-38  133.1   0.2    1.1  1  Peptidase_M24  Metallopeptidase family M24


Domain annotation for each model (and alignments):
>> Peptidase_M24  Metallopeptidase family M24
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.1   0.2   5.8e-43     1e-38       3     207 ..     100     397 ..      98     399 .. 0.87

  Alignments for each domain:
  == domain 1  score: 133.1 bits;  conditional E-value: 5.8e-43
                    HHHHHHHHHHHHHHHHHHHHTTCBHHHHHHHHHHHHH....HHTTTCEESSSSEEEEGGGGGSTTTBC...SSSB--TTEEEEEEEEEEETTEEEE CS
  Peptidase_M24   3 irkaariasaaleavleaikpgvterelaaeieattl....krhgarglafppivasgenaavlhytp...ndrvlkegdlvlidagaeydgyasD 91 
                     r aa++++ a++ +++ +kpg++  ++a+  e++++    +++ + glafp   +++ n+ ++hytp   +++v+ ++d++++d+g +++g ++D
     EFC38241.1 100 ARHAAEVHRTARKWFKTIVKPGMKVIDAAETYENKVRelleADKKKSGLAFP--LGCSLNHVAAHYTPnsgDETVIGKDDVIKFDLGTHVNGTIID 193
                    699*************99***************9955333333449999***..**************7766777********************* PP

                    EEEEEECSSGSHHHHHHHHHHHHHHHHHHHC-STTSBHHHHHHHHHHHHHHTTB........CCGBSSCSEEEESS.SSSEE..EEEESSSTTCSS CS
  Peptidase_M24  92 itrTvlvGkftpeqrelyeavleaqeaaikavkpGvtlseidaaarevlesagl........akffphglGHgvGl.evhde..gpsvsresndgr 176
                    +++T++    +++++ l++av++a+++++ka+  +v+l++++aa++ev+es+++        ++ + +++GH+v + +vh +  +p+v+  + +++
     EFC38241.1 194 SAFTMCW---NDQYQPLLDAVKDATNMGVKAAGIDVRLGDVGAAIQEVMESYEVtingkthkVRSIENLCGHSVERyRVHAGksVPIVA--TEENT 284
                    *****99...778999***********************************86666777777788899*******99***774466677..5679* PP

                    B--TTBEEEEEE......EEEEETTT...................................................................... CS
  Peptidase_M24 177 kleeGmvftiEp......giyfapge...................................................................... 196
                    k+ee++ f+iE+      g+ +++g+                                                                      
     EFC38241.1 285 KMEENEFFAIETfgstgkGYINEEGVcshygreytyngdgselrnkdskdllkvinenfgsipfcrryldrigqkkyltalrdlvnngivneyppl 380
                    ************999987666555557777777888888888999999999999999999999999999999999999999999999999999999 PP

                    ......EEEEEBEEEEE CS
  Peptidase_M24 197 ......ggvriedtvlv 207
                          +++++e+t+ +
     EFC38241.1 381 vdvrgcYTAQFEHTIFL 397
                    99999889999999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (411 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1884  (0.105081); expected 358.6 (0.02)
Passed bias filter:                      998  (0.055664); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.47
# Mc/sec: 2649.06
//
Query:       EFC38242.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.9e-09   35.3  13.1     0.0013   18.5   3.1    3.6  3  PAP2_3    PAP2 superfamily
     0.0001   22.1   1.0    0.00021   21.1   1.0    1.6  1  PAP2      PAP2 superfamily


Domain annotation for each model (and alignments):
>> PAP2_3  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.7    0.0014        13       3      62 ..     116     180 ..     114     189 .. 0.69
   2 !   16.2   0.0   7.2e-07    0.0065      60     140 ..     233     334 ..     228     340 .. 0.64
   3 !   18.5   3.1   1.4e-07    0.0013     148     189 ..     362     403 ..     358     404 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0014
      PAP2_3   3 lialdralgldweaalnk.lllahpalavilalaYaslhfqvtllvl.....vllflrrrerlref 62 
                 ++ +d+ l ++    ++  + l hp l+v++a+ Y + hf+++l+v+     ++l+ ++re l+e+
  EFC38242.1 116 IATIDKYLMFGLAMPHELlANLYHPFLDVFFAIPYLA-HFVYPLAVYpvivcIFLWKPNRESLKET 180
                 56788888888888888766778999*******9995.7777665541111155556666666665 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 7.2e-07
      PAP2_3  60 reflttlllatllgllvyalfPaagP.............................rlleeagfvdtvaaaslagalrdgasravllrgtienglaafPS 129
                 + +l++l ++ ++ +++ ++fP+a+P                              +++ea+f ++ +   ++       ++ + ++gt   ++ +f S
  EFC38242.1 233 KCYLLSLGVISIIQVTLCFFFPTAPPwfrdntikyeeyyemigdatldmplpvfpLYAPEARFEMVDRLIGYEL------FAGIYGKGT--IKFGSFYS 323
                 568899********************555555555555555555444444444332224444444444444444......444444444..77888*** PP

      PAP2_3 130 lHvawallval 140
                 lHv+w+ ++++
  EFC38242.1 324 LHVGWTAIITF 334
                 *****999876 PP

  == domain 3  score: 18.5 bits;  conditional E-value: 1.4e-07
      PAP2_3 148 krllrvlalllnvlmivatvatgnHYlvDviaGvalalvaia 189
                 ++++ ++++ + v++++a ++ ++H+++D +++v+la+++ +
  EFC38242.1 362 WTFYQIFMIQYLVWIFLASMYSAHHFMIDGLVAVVLAVIITK 403
                 567889999*****************************9875 PP

>> PAP2  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   1.0   2.3e-08   0.00021       4     131 ..     234     409 ..     231     414 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 2.3e-08
        PAP2   4 alllalalaalltsvlKdlvgrpRPfflaeetkldtqvstletses....................................keakesfPSgHsafafa 66 
                 ++ll+l++  ++++ l  ++    P f ++++k+ +  ++  + +                                     +  + sf S H   ++ 
  EFC38242.1 234 CYLLSLGVISIIQVTLCFFFPTAPPWFRDNTIKYEEYYEMIGD-ATldmplpvfplyapearfemvdrligyelfagiygkgTIKFGSFYSLHVGWTAI 331
                 6778888888888888888888888888888888888444443.44588888888888888888888888888888888888888999*****966666 PP

        PAP2  67 lalllalllrrkrkkig.............lvllalillllavlvalsRlylgvHflsDvlaGlliGialaalayrlv 131
                 + ++  +++ +  ++++              + +  + + ++v++ l+ +y  +Hf  D l++++++++++ l++ + 
  EFC38242.1 332 ITFIELFVVYKQESNVDeesltrseksgksWTFYQIFMIQYLVWIFLASMYSAHHFMIDGLVAVVLAVIITKLSTMII 409
                 66665555555555555789********888888899999******************************99887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       977  (0.0544927); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.45
# Mc/sec: 2800.45
//
Query:       EFC38243.1  [L=1250]
Description: hypothetical protein NAEGRDRAFT_73934 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.031   14.4   0.0      0.079   13.1   0.0    1.6  1  Cas_Csy4  CRISPR-associated protein (Cas_Csy4)


Domain annotation for each model (and alignments):
>> Cas_Csy4  CRISPR-associated protein (Cas_Csy4)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   4.4e-06     0.079      50     118 ..     515     584 ..     493     624 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 4.4e-06
    Cas_Csy4  50 sklRlfg.seeeLeelqakkwlkrlrdyvhiseiraVpekvsgyrvvrRvqekssae..rlarrrlkrqglt 118
                  + ++fg se +L++l  +++ ++++d ++i++ +  p++ +  + v+R +e+++++  + +++++k ++ +
  EFC38243.1 515 GIAKFFGkSEVALKTLILNSRGRDISDNFQIQGYTILPDEYE--KAVKRIEEEKKKAqtQEEEKKAKPNTKS 584
                 57899**9*******************************999..7777777666655235556666655444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1519  (0.0847231); expected 358.6 (0.02)
Passed bias filter:                      521  (0.0290591); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.92u 0.32s 00:00:01.24 Elapsed: 00:00:00.51
# Mc/sec: 7445.13
//
Query:       EFC38244.1  [L=410]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.8e-13   49.7   0.2    4.8e-13   49.7   0.2    3.5  5  CTD_bind   RNA polymerase II-binding domain.
     0.0072   16.5   1.6     0.0072   16.5   1.6    2.9  3  CREPT      Cell-cycle alteration and expression-elevated prot
  ------ inclusion threshold ------
       0.06   13.4   0.4       0.14   12.2   0.4    1.6  1  DUF3763    Protein of unknown function (DUF3763)
       0.68   10.1   5.7        2.2    8.4   4.3    2.6  2  DUF5101    Domain of unknown function (DUF5101)
        2.8    7.2   5.6        3.9    6.7   0.7    2.5  3  BAF250_C   SWI/SNF-like complex subunit BAF250/Osa
        2.9    6.0   8.7          4    5.5   8.7    1.1  1  SSP160     Special lobe-specific silk protein SSP160
        6.4    6.9  12.6        2.6    8.2   1.3    3.0  3  Fib_alpha  Fibrinogen alpha/beta chain family


Domain annotation for each model (and alignments):
>> CTD_bind  RNA polymerase II-binding domain.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.1   2.9e+03      47      58 ..      20      31 ..      18      33 .. 0.85
   2 !   49.7   0.2   1.9e-16   4.8e-13       1      63 []      42     103 ..      42     103 .. 0.93
   3 ?   -1.9   0.2       2.5   6.4e+03       9      24 ..     182     202 ..     181     211 .. 0.53
   4 ?   -2.2   0.1       3.1   7.9e+03      47      60 ..     274     287 ..     252     289 .. 0.68
   5 ?   -2.0   0.0       2.6   6.7e+03       5      18 ..     376     389 ..     374     403 .. 0.64

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.1
    CTD_bind 47 kkklkrllniWe 58
                 kk +++++iW 
  EFC38244.1 20 VKKAQEIVSIWA 31
                5899*******5 PP

  == domain 2  score: 49.7 bits;  conditional E-value: 1.9e-16
    CTD_bind   1 kLnllYLaNdvlqnskrkqkdefapaFapvlpeafadaykkapekikkklkrllniWeernvf 63 
                 kL   YLaNdv+qns+ k+++ f+++F++vlp  ++d ++   ek++k+l+r+ +i eer++f
  EFC38244.1  42 KLCYYYLANDVIQNSR-KKTNAFVEQFQAVLPGSLRDNISLMTEKDRKSLQRIFSILEERKIF 103
                 78999*********75.555********************77899*****************9 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2.5
    CTD_bind   9 Ndvlqnskrkq.....kdefa 24 
                 N+++q  +  q     +d+++
  EFC38244.1 182 NEIVQANRVDQknftdNDKLV 202
                 899995433332344444444 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 3.1
    CTD_bind  47 kkklkrllniWeer 60 
                  +++++l++ W ++
  EFC38244.1 274 FNQYNDLIKEWNDN 287
                 45667788888765 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 2.6
    CTD_bind   5 lYLaNdvlqnskrk 18 
                 l L+N++l     k
  EFC38244.1 376 LNLVNSILSALGNK 389
                 56999999854333 PP

>> CREPT  Cell-cycle alteration and expression-elevated protein in tumour
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1       0.2   5.1e+02      11      64 ..      54     108 ..      49     115 .. 0.80
   2 ?    0.6   0.5      0.23   5.9e+02      42      97 ..     160     215 ..     144     226 .. 0.71
   3 !   16.5   1.6   2.8e-06    0.0072      46     122 ..     228     305 ..     223     306 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.2
       CREPT  11 ens.assdaavReriaklPpevsdvsllekikdkeeaekllkqveealellaeYn 64 
                 +ns   ++a v +  a lP ++ d   l+  kd+++ ++ ++  ee    +a++ 
  EFC38244.1  54 QNSrKKTNAFVEQFQAVLPGSLRDNISLMTEKDRKSLQRIFSILEERKIFTADFS 108
                 5555667888888899999999999999999999999999988888777776665 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.23
       CREPT  42 dkeeaekllkqveealellaeYnkrLeaeleeRkklakmledfleaqkellakaee 97 
                 ++++a +ll + ++ ++ l ++n+  +a+  + k+ + + +  +e+++  l+++e 
  EFC38244.1 160 SSNDALTLLANTNSVVKSLVQFNEIVQANRVDQKNFTDNDKLVQECKQRVLDRHEL 215
                 56677777788888888888888888888777777777766666666666666554 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 2.8e-06
       CREPT  46 aekllkqveealellaeYnkrLeaeleeRkklakmledfleaqkellakaeekleelkek.lekvksvrkelkshiqs 122
                  ++l+  ve  l+  ++Y   L++e ++Rk+ ++ le+ l+ q++l ++ +  ++e ++  l  +++  ++l+ h++s
  EFC38244.1 228 LKQLQGDVEGVLTKCSDYKFALAKENNKRKEYMTALEQELNEQRNLFNQYNDLIKEWNDNyLVDLQKISTSLEIHLNS 305
                 578999999999********************************************9865378999999999999876 PP

>> DUF3763  Protein of unknown function (DUF3763)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.4   5.6e-05      0.14       5      24 ..     257     276 ..     253     277 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.6e-05
                 HHHHHHHHHHHHHHHHHHHT CS
     DUF3763   5 leqleeleqelrkqrslFhq 24 
                 +e +++leqel +qr+lF+q
  EFC38244.1 257 KEYMTALEQELNEQRNLFNQ 276
                 67799*************98 PP

>> DUF5101  Domain of unknown function (DUF5101)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.4   6.1e+03      17      44 ..      82     107 ..      59     109 .. 0.63
   2 ?    8.4   4.3   0.00086       2.2      57      93 ..     248     284 ..     188     289 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.4
     DUF5101  17 kkkkkkklsdkekvleylkevkaktkdy 44 
                 +++k++  +  +++ + l+e k  t d+
  EFC38244.1  82 MTEKDR--KSLQRIFSILEERKIFTADF 107
                 333333..44566666666666666666 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00086
     DUF5101  57 leGkEnqevvelkealeevleEnEklvkekvdLiael 93 
                    kEn++ +e  +ale+ l+E+ +l+++ +dLi e 
  EFC38244.1 248 ALAKENNKRKEYMTALEQELNEQRNLFNQYNDLIKEW 284
                 567******************************9875 PP

>> BAF250_C  SWI/SNF-like complex subunit BAF250/Osa
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.1     0.034        88     199     234 ..     158     193 ..     154     208 .. 0.81
   2 ?    6.7   0.7    0.0015       3.9      42      98 ..     249     302 ..     242     308 .. 0.81
   3 ?   -3.3   0.0       1.7   4.3e+03     153     179 ..     358     386 ..     353     391 .. 0.66

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.034
    BAF250_C 199 aqadeavaraialqkssislLisFiedaeakarava 234
                 +++++ +++++a  +s ++ L++F e  +a+   ++
  EFC38244.1 158 SSSSNDALTLLANTNSVVKSLVQFNEIVQANRVDQK 193
                 6778889999**************999887765554 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0015
    BAF250_C  42 lhhehperkkkaeeydkeeeedeascseeewwvdvlealrenalvllaniagqLdls 98 
                 l+ e+ +rk+ ++ +++e +e+    +  +++ d++++  +n lv l +i+ +L++ 
  EFC38244.1 249 LAKENNKRKEYMTALEQELNEQ---RNLFNQYNDLIKEWNDNYLVDLQKISTSLEIH 302
                 5667777888888888875443...46778999*********************985 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 1.7
    BAF250_C 153 dsNvdlllatppfsrlek..lvdvLvrll 179
                 ++N dl+  t p+s  +   lv+ + + l
  EFC38244.1 358 EDNEDLFTETKPISTTNTlnLVNSILSAL 386
                 78999999999988765411455555555 PP

>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   8.7    0.0016         4      86     161 ..     102     179 ..      86     191 .. 0.72

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0016
      SSP160  86 nliamisanvqaiqsgsgsasssssssatstss.ststtssssttssnsttttsnstsssnstssgltssasvv.sli 161
                  + a  s++ +++  gs   sss +ss +s ss s    ss+s        ++sn++sssn + + l+ + svv sl+
  EFC38244.1 102 IFTADFSSECKSVIDGSLGGSSSNTSSDNSRSSgSGKERSSESNPLKRERPSSSNTSSSSNDALTLLANTNSVVkSLV 179
                 556778888899888986655555555555544166677778888888888899*************99999983444 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1      0.73   1.9e+03      47      73 ..      53      79 ..      22     113 .. 0.64
   2 ?    8.2   1.3     0.001       2.6      42     113 ..     163     237 ..     147     246 .. 0.80
   3 ?    4.7   1.7     0.012        31      25      71 ..     248     294 ..     240     309 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.73
                CCCHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha 47 isnstkeaeelvkeikdslrekqkskk 73
                i+ns k+++  v++ + +l    + + 
  EFC38244.1 53 IQNSRKKTNAFVEQFQAVLPGSLRDNI 79
                556666666666666655555444443 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.001
                 CCCCCCCCHHHHHHHHHH..HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCH.HHHHHHHHHHHH CS
   Fib_alpha  42 neleeisnstkeaeelvk..eikdslrekqkskkdndnvikksskeleeeilrlketidaqe.snirvLqnvles 113
                 + l+ ++n+++ +++lv+  ei +  r +qk+ +dnd+++++ ++++ ++++  ++++ +    ++++Lq+ +e 
  EFC38244.1 163 DALTLLANTNSVVKSLVQfnEIVQANRVDQKNFTDNDKLVQECKQRVLDRHELREDQLAHSTpFTLKQLQGDVEG 237
                 55666777777777776433889999999****************998888888888888888999999987765 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.012
                 CCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  25 lllkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqks 71 
                 +l k +++ k+ ++ le+el+e +n  ++ ++l+ke +d +  + ++
  EFC38244.1 248 ALAKENNKRKEYMTALEQELNEQRNLFNQYNDLIKEWNDNYLVDLQK 294
                 57788888999999999999999999999999999988877666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1771  (0.0987785); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.76u 0.36s 00:00:01.12 Elapsed: 00:00:00.57
# Mc/sec: 2172.44
//
Query:       EFC38245.1  [L=432]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0094   15.4   0.2      0.089   12.2   0.0    2.1  2  Cytomega_gL  Cytomegalovirus glycoprotein L


Domain annotation for each model (and alignments):
>> Cytomega_gL  Cytomegalovirus glycoprotein L
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0     0.015   2.7e+02     166     195 ..     255     284 ..     230     286 .. 0.76
   2 !   12.2   0.0   4.9e-06     0.089      54     138 ..     284     368 ..     279     380 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.015
  Cytomega_gL 166 dglynllkefllktsldldllkhlekyrak 195
                   + yn++k+++ + +ld   +++  k+ ++
   EFC38245.1 255 RSSYNTIKYIMEHYNLDIYEIEKRTKFFSR 284
                  457**************9888777777666 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 4.9e-06
  Cytomega_gL  54 efledlallqnnpdqlralltllrsdeasdWlsflrGyseCdspssavytCvedlCrkydlerlsyvrdlftenvlGlelvppsl 138
                   fl +l+    n++ql+  +  +  +   +W ++   +   ++    ++  v+  C + + e l y r+ ft n+  l+++  sl
   EFC38245.1 284 RFLGSLLRYDINTEQLKSNIETIFPNSPIEWKKLASIHDGINEITERIISLVQTCCERPSGEELLYLRECFTPNIFDLNVMVRSL 368
                  58888888888*********9999999999*99999999999999********************************99877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2509.24
//
Query:       EFC38246.1  [L=561]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.6e-07   30.4   8.0    3.6e-07   30.4   8.0    3.0  3  DUF1011     Protein of unknown function (DUF1011)
  ------ inclusion threshold ------
       0.46   11.0   0.1       0.46   11.0   0.1    3.7  4  DUF4231     Protein of unknown function (DUF4231)
       0.76    9.5   3.9        9.5    6.0   0.0    3.2  3  Spore_YhaL  Sporulation protein YhaL
          1    9.0   5.3        6.2    6.5   0.0    3.3  3  DUF4131     Domain of unknown function (DUF4131)
        4.1    7.6   5.4        1.6    8.9   0.0    2.9  3  UL41A       Herpesvirus UL41A
        5.9    6.8   7.3       0.63   10.0   0.6    2.1  2  MCRS_N      N-terminal region of micro-spherule protein


Domain annotation for each model (and alignments):
>> DUF1011  Protein of unknown function (DUF1011)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.56   1.7e+03      40      62 ..     136     157 ..     129     173 .. 0.77
   2 ?   -2.2   0.3       1.7   5.2e+03      91      91 ..     266     266 ..     227     296 .. 0.54
   3 !   30.4   8.0   1.2e-10   3.6e-07       5      97 ..     328     422 ..     324     425 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.56
     DUF1011  40 lsvtlssianPlacflamflpvr 62 
                 ls++l++i+ P+++f++m++++ 
  EFC38246.1 136 LSLQLANIV-PFMYFVFMIFKKM 157
                 778888885.8999999988764 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.7
     DUF1011  91 p 91 
                 p
  EFC38246.1 266 P 266
                 2 PP

  == domain 3  score: 30.4 bits;  conditional E-value: 1.2e-10
     DUF1011   5 afllvllaivnaltnGvlpsvqsYsclpYGnka..YhlsvtlssianPlacflamflpvrslkvlgvltllglllsaYilalAvlsPtppLvgst 97 
                 + l ++++++++  nGv+ s+ +Y  + Y ++a   ++++t++ i++P+a+ +a+++p +++ + ++  l+ ++ ++++ ++A+  P+ppL+ st
  EFC38246.1 328 VRLIFFQFLISCSENGVVVSIMPYVFAHYKHHAtlLQYAITIGMIISPIASGVAYLVPFYNFFIAMFCHLIWIVGACFLTVIAFNNPNPPLKYST 422
                 66889999*********************9988335678999*************************************************9776 PP

>> DUF4231  Protein of unknown function (DUF4231)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.3       0.2     6e+02      18      75 ..     179     236 ..     168     243 .. 0.85
   2 ?    2.6   0.7     0.064   1.9e+02      26      71 ..     251     298 ..     237     313 .. 0.73
   3 ?   -2.5   0.2       2.5   7.4e+03      12      35 ..     355     378 ..     347     384 .. 0.76
   4 ?   11.0   0.1   0.00016      0.46      15      74 ..     390     449 ..     387     457 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.2
     DUF4231  18 rllrlitivlgallpilvssklgagvsvlkiltallsalvailaaleeffrykerWrr 75 
                  +l+l+ i +gal+ +   +  + +++ +++l+ +  + v+ +++   f+ +  ++++
  EFC38246.1 179 SILSLFVIGIGALIGMSFLWNIPINGRSWPFLIMMFLVGVSDCTSTLLFYPFVLHFKH 236
                 5789999999999999999888899999999999999999999999999988877776 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.064
     DUF4231  26 vlgallpilvs..sklgagvsvlkiltallsalvailaaleeffryke 71 
                 +++ +++i+++   +   +++v+ i++a++ a++ ++  l  f  y +
  EFC38246.1 251 LIASIISIIQNstPTPLFPFWVFCIIIAGITAISLVSYCLLRFLPYSK 298
                 344555555556766777788888888888888888888888877766 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.5
     DUF4231  12 rakrrfrllrlitivlgallpilv 35 
                 ++k  + ll+ ++ ++ +++pi++
  EFC38246.1 355 HYKHHATLLQYAITIGMIISPIAS 378
                 667777778888888888888776 PP

  == domain 4  score: 11.0 bits;  conditional E-value: 0.00016
     DUF4231  15 rrfrllrlitivlgallpilvssklgagvsvlkiltallsalvailaaleeffrykerWr 74 
                  ++++++li iv++ +l++++    +++    +++  +l ++++++ ++++f++ ke  +
  EFC38246.1 390 FIAMFCHLIWIVGACFLTVIAFNNPNPPLKYSTAFGGFLVVVAILTKGFMSFCKTKEFLH 449
                 57899*****************88888888999999999999999*********999655 PP

>> Spore_YhaL  Sporulation protein YhaL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0    0.0032       9.5       1      11 [.     268     278 ..     268     315 .. 0.73
   2 ?   -3.5   0.3       2.9   8.6e+03       6      16 ..     365     375 ..     365     377 .. 0.87
   3 ?    3.5   0.1     0.019        58       6      36 ..     427     456 ..     427     472 .. 0.72

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0032
  Spore_YhaL   1 iPwWvYlviag 11 
                 +P+Wv+ +i++
  EFC38246.1 268 FPFWVFCIIIA 278
                 7*****98764 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.9
  Spore_YhaL   6 YlviagIlfSg 16 
                 Y++ +g+++S 
  EFC38246.1 365 YAITIGMIISP 375
                 9999****996 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.019
  Spore_YhaL   6 YlviagIlfSgymavktakeEreldqefIEk 36 
                 +lv+++Il  g+m+   +ke  +   + IEk
  EFC38246.1 427 FLVVVAILTKGFMSFCKTKEFLH-SHQVIEK 456
                 79***********9987776444.3445665 PP

>> DUF4131  Domain of unknown function (DUF4131)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   1.9      0.33   9.8e+02       9      44 ..     183     218 ..     177     229 .. 0.55
   2 ?    1.8   0.2     0.056   1.7e+02       3      63 ..     268     305 ..     238     341 .. 0.52
   3 ?    6.5   0.0    0.0021       6.2       9     127 ..     397     522 ..     388     525 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.33
     DUF4131   9 llalllllllllllllrrrprrrvllllllllllal 44 
                 l+++++ +l+   +l++   + r + +l++ +l+++
  EFC38246.1 183 LFVIGIGALIGMSFLWNIPINGRSWPFLIMMFLVGV 218
                 333344444444444444555555555555555554 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.056
     DUF4131   3 lplalvllalllllllllllllrrrprrrvllllllllllallgfalrapqpnandlsqll 63 
                  p+++++++++++++                       + ++++++lr +  ++++l + +
  EFC38246.1 268 FPFWVFCIIIAGITA-----------------------ISLVSYCLLRFLPYSKKELRRDV 305
                 344444444444444.......................44444444444433333333333 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0021
     DUF4131   9 llalllllllllllllrr...rprrrvllllllllllallgfalrapqpnandlsqllesgqeviveGvvaslpeltgsgtrfvleverv.....lsag 99 
                 l+ ++++++l+ +++++     +  + ++++l++ ++++ gf     +++  + +q++e++ e i++  +++  ++t++++ ++ + e++      +++
  EFC38246.1 397 LIWIVGACFLTVIAFNNPnppLKYSTAFGGFLVVVAILTKGFMSFCKTKEFLHSHQVIEKQDEMIYKKLLLESRKKTEQTQHVEEKLEQIepistEQQE 495
                 556666667777776655777777777888888888888899999999999999****99999999999999999999999***********9999999 PP

     DUF4131 100 ktkpvsgrvlvtvpkspaeglrpGdrlr 127
                 +t   +g  ++ +p ++ + l  G+rlr
  EFC38246.1 496 ATIVPNGEEIIDLPINQKK-LTFGERLR 522
                 999999********99999.99999987 PP

>> UL41A  Herpesvirus UL41A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.0   0.00052       1.6      13      58 ..     130     178 ..     124     181 .. 0.74
   2 ?   -1.6   0.4         1   3.1e+03      20      40 ..     368     396 ..     358     402 .. 0.58
   3 ?   -1.5   0.1      0.92   2.7e+03      31      58 ..     424     451 ..     421     471 .. 0.66

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00052
       UL41A  13 gyvdmnvcigmigvvcfvfgvfil...ifcstlkafyvrqktyhllgte 58 
                   vdmn+ + +  +v f++ vf++   ++   lk    r+ t+ ++ t 
  EFC38246.1 130 IAVDMNLSLQLANIVPFMYFVFMIfkkMIQRKLKPTTTRKSTFDIVDTV 178
                 569******9999998776666541115677889999999999888775 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1
       UL41A  20 cigmi......gvvcfv..fgvfilifcs 40 
                  igmi      gv  +v  +  fi +fc 
  EFC38246.1 368 TIGMIispiasGVAYLVpfYNFFIAMFCH 396
                 45554333332343333326788888886 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.92
       UL41A  31 fgvfilifcstlkafyvrqktyhllgte 58 
                 fg f+++     k f    kt  +l + 
  EFC38246.1 424 FGGFLVVVAILTKGFMSFCKTKEFLHSH 451
                 7888888877778887777777666544 PP

>> MCRS_N  N-terminal region of micro-spherule protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   1.2      0.27   7.9e+02     129     184 ..      27      82 ..      13      84 .. 0.80
   2 ?   10.0   0.6   0.00021      0.63     147     195 ..     439     487 ..     431     490 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.27
      MCRS_N 129 qLLpdqsvqplqkedkvllsfsdaeeelddselsesedevleaeleladrkqkrei 184
                  ++++++ q+ q + +  +   + +  ++d+++ ++  e+ ++e++ ++r   r+i
  EFC38246.1  27 DVVDNHHQQQYQASAEKAIANGQSDVVVNDAQVLDKMGEITKNEMNQTERFYLRKI 82 
                 45667777788888888788888999999999999999999999999988777766 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00021
      MCRS_N 147 lsfsdaeeelddselsesedevleaeleladrkqkreirqLEnelsrwq 195
                 +sf +++e l+ +++ e++de++ + l l++rk+  + +++E++l++++
  EFC38246.1 439 MSFCKTKEFLHSHQVIEKQDEMIYKKLLLESRKKTEQTQHVEEKLEQIE 487
                 78888899999999*******************************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (561 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1344  (0.0749624); expected 358.6 (0.02)
Passed bias filter:                      605  (0.0337442); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.81u 0.38s 00:00:01.19 Elapsed: 00:00:00.56
# Mc/sec: 3034.17
//
Query:       EFC38247.1  [L=623]
Description: PAP2_haloperoxidase domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-11   43.7   0.0      4e-11   42.8   0.0    1.4  1  PAP2      PAP2 superfamily
     0.0018   18.1   0.0     0.0069   16.2   0.0    2.0  2  VCPO_N    Vanadium chloroperoxidase N-terminal domain


Domain annotation for each model (and alignments):
>> PAP2  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.8   0.0   4.5e-15     4e-11       5     131 ..     485     616 ..     480     620 .. 0.90

  Alignments for each domain:
  == domain 1  score: 42.8 bits;  conditional E-value: 4.5e-15
        PAP2   5 lllalalaalltsvlKdlvgrpRPfflaeetkldtqvstletseskeakesfPSgHsafafalalllalllrrkrkkig........lvllalilllla 95 
                 l+ ++a a++++   K++++ +RP+++ ++   + +++ l +   +++++ ++SgHs+f++a+a +l+lll++  ++++         +++++ l  +a
  EFC38247.1 485 LGCSVADAGIVSWDHKYFYNALRPVTAVNNRNRNLNWFPLLA---TPPFPEYTSGHSTFSGAAARILSLLLGSDDITFDvtsdgykyHTRTFNRLSDAA 580
                 455666667776667****************99999877766...6788999*********************************************** PP

        PAP2  96 vlvalsRlylgvHflsDvlaGlliGialaalayrlv 131
                  + + sR+y g+Hf  +  aG+  G+a+a ++y++ 
  EFC38247.1 581 KEAGKSRIYGGIHFEYANQAGWNSGVAVANAVYNQL 616
                 ******************************999875 PP

>> VCPO_N  Vanadium chloroperoxidase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   7.7e-07    0.0069       5      57 ..     228     274 ..     225     305 .. 0.90
   2 ?   -1.9   0.0      0.27   2.4e+03     139     156 ..     599     616 ..     533     620 .. 0.64

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 7.7e-07
      VCPO_N   5 eepaeyntnyilyWnsvaldlnrlthsvagPqtgPpisaralgilhlaihday 57 
                  e++ +n+++i+ Wn+v l       +v   + +Pp+++ra++i+h a++da 
  EFC38247.1 228 TEKDIFNEDFIIKWNNVLL------ATVRDFKVAPPVASRAMAIVHSAVDDAL 274
                 68889**********9866......67889999******************95 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.27
      VCPO_N 139 sesyrfGvavaeailkll 156
                  + ++ Gvava+a+ + l
  EFC38247.1 599 QAGWNSGVAVANAVYNQL 616
                 345666777777666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (623 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       375  (0.0209158); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 3392.00
//
Query:       EFC38248.1  [L=330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.6e-06   25.9   0.0      1e-05   25.5   0.0    1.2  1  NAD_binding_10   NAD(P)H-binding
    4.9e-05   23.7   0.0    0.00012   22.5   0.0    1.6  1  Semialdhyde_dh   Semialdehyde dehydrogenase, NAD binding doma
    0.00014   21.4   0.0    0.00027   20.5   0.0    1.5  1  Epimerase        NAD dependent epimerase/dehydratase family
  ------ inclusion threshold ------
      0.014   15.0   0.0      0.034   13.7   0.0    1.8  1  NmrA             NmrA-like family
      0.017   15.4   0.0      0.031   14.5   0.0    1.4  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
      0.074   13.2   0.0       0.18   11.9   0.0    1.8  1  DapB_N           Dihydrodipicolinate reductase, N-terminus
       0.12   13.1   0.0       0.33   11.7   0.0    1.8  2  DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomer


Domain annotation for each model (and alignments):
>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.5   0.0   4.1e-09     1e-05       1     158 [.      56     243 ..      56     280 .. 0.68

  Alignments for each domain:
  == domain 1  score: 25.5 bits;  conditional E-value: 4.1e-09
                     TTTSHHHHHHHHHHHHC-...T-EEEEEETTHHHCHHHHCTTTCEEEE--TT-C.CHHHHHHTT-SEEEES---TCC....HHHH.......... CS
  NAD_binding_10   1 GAtGkvGrllvkellarg...ghevtalvRnpeklaeleaeeglevvegdvtdv.edlaealkgadaVvsalggggk....deeg.......... 77 
                     G tG vG+ +v+ l +++     +++a+ R+++   ++e +  +e +++d +d  +++ ++++ +d  +++lg++ k    d++           
      EFC38248.1  56 GSTGLVGKNVVRVLSQQNpqeYAKIVAISRRKDNPFNYETSVPIEHITLDSLDNlDQISDVFNEVDEAYCCLGTTIKrvgnDKQKfrhvdfdypd 150
                     89***************99977889***999998888998888888888887654*****************88777677544446777888889 PP

                     ......HHHHHHHHHH..CT--EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHH.HHHHSSSE....EEEEEE-CEE-ST--SEEEEE CS
  NAD_binding_10  78 ......aknivdaake..agvkRfvlvsaigvgdevpgefgewnkellkaylaakraaee.llrasgld....wTivrpggLtdepttkyrvve 158
                            k+  +aa++  ++ k+f lv++ g++ +++   ++++   +++ +a k+   +   + + l+      i++pg L  e +++ r++e
      EFC38248.1 151 sfanlvYKSFTNAAQNtsENLKQFFLVTSTGADSSSMFFYNQVK-GDIEKSVAQKQLDYQqFTQGKSLNqssyCHIIKPGLLIGERENDERFGE 243
                     98888888889999874478*************76554444443.4455555555544440444444443332468888888766655555543 PP

>> Semialdhyde_dh  Semialdehyde dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0   4.6e-08   0.00012       2      77 ..      52     130 ..      51     135 .. 0.72

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 4.6e-08
                     EEEETTTSHHHHHHHHHHHCTSSEEEEEEEESTTTTTSBHHHHSGGGTTTECEBEEE...GGGGGCTT-SEEEE-SCHH CS
  Semialdhyde_dh   2 vaivGatGyvGqellrlLeehpevelvvllsssrsaGkklaeavkaleegkdlkved...vdeeelkevdivflalpag 77 
                     + +vG tG vG++++r+L+++ + e + +++ sr + ++++   + + e+ +l   d     ++ ++evd + ++l+  
      EFC38248.1  52 AIVVGSTGLVGKNVVRVLSQQNPQEYAKIVAISRRKDNPFNYETSVPIEHITLDSLDnldQISDVFNEVDEAYCCLGTT 130
                     679*****************99999999999999888888877663333333333222323445558888888888765 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   1.1e-07   0.00027       2      71 ..      53     126 ..      52     159 .. 0.74

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.1e-07
                 EEETTTSHHHHHHHHHHHHCT...SE.EEEEES-STTTTCHHCHHCEEEE--TT-HHHHHHHHHHH.T-SEEEE- CS
   Epimerase   2 lVtGatGfiGsalvkallekg...ye.vigldrlssasntarledlelveldltdrsalerlfkee.qpdavihl 71 
                 +V+G tG++G+++v+ l +++   y  +++++r+ ++++++ +  + + ++ l   ++l+++ + + ++d+ + +
  EFC38248.1  53 IVVGSTGLVGKNVVRVLSQQNpqeYAkIVAISRR-KDNPFNYETSVPIEHITLDSLDNLDQISDVFnEVDEAYCC 126
                 8*********************996648888887.6666677777766666666666666555544467776665 PP

>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   1.3e-05     0.034       2      75 ..      53     130 ..      52     175 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.3e-05
                 EESSTTSHHHHHHHHHHHH....HT-EEEEEES-S-SHHHHHHHHSTTEEE.ES-TT-HHHHHHHHTT-SEEEE---GG CS
        NmrA   2 lviGaTGrqGksvvrallk....aghkvralvRdtkselakslkeaGvelv.kgdlddkeslvealkgvdvvfsvtgfy 75 
                 +v+G+TG  Gk vvr+l +    +  k+ a+ R  ++    +  + + e +  ++ld+ + ++ ++++vd +++ +g++
  EFC38248.1  53 IVVGSTGLVGKNVVRVLSQqnpqEYAKIVAISRRKDNPFNYE-TSVPIEHItLDSLDNLDQISDVFNEVDEAYCCLGTT 130
                 59****************977655567888888877776666.567888886788*******************99865 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   1.2e-05     0.031       2      61 ..      53     111 ..      52     123 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.2e-05
                      EEE--.SHHHHHHHHHHHCTCCT-G.EEEEEESSHHHHHHHHCHHTTTCEEEEE--TTTHHH CS
  Sacchrp_dh_NADP   2 liiGa.GsvGqavaellarhfdvda.eitvadrskeklealaakalgvrfeaialdaenyea 61 
                      +++G+ G vG+ v+++l+++++ +  +i+ ++r k++  +     ++v +e i+ld  +  +
       EFC38248.1  53 IVVGStGLVGKNVVRVLSQQNPQEYaKIVAISRRKDNPFNYE---TSVPIEHITLDSLDNLD 111
                      799*******************988**********9954443...66677777766655544 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   7.2e-05      0.18       2      66 ..      51     118 ..      50     165 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 7.2e-05
                 EEEEETTTSHHHHHHHHHHHHS...TTEEEEEEEETTCSTTTTTBHHHHSSSS--S-BEBSSHHHHHH CS
      DapB_N   2 kvavvGasGrmGkevvkaveea...edlelvaavdrkeselegkdagellglgklgvavtddleevle 66 
                 k +vvG +G +Gk+vv++++++   e +++va   rk+++++ +    + +++  ++   d++++v++
  EFC38248.1  51 KAIVVGSTGLVGKNVVRVLSQQnpqEYAKIVAISRRKDNPFNYETSVPIEHITLDSLDNLDQISDVFN 118
                 679*****************983334555666666666555555544444444444444444444444 PP

>> DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00013      0.33       2      34 ..      53      87 ..      52     124 .. 0.82
   2 ?   -2.6   0.0       3.4   8.8e+03      37      51 ..     271     285 ..     259     316 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00013
                     EEESTTSHHHHHHHHHHHHC.TTTE.EEEEEEESS CS
  DXP_reductoisom  2 viLGsTGSIGtqtLdvieen.pdkf.evvalaags 34
                     +++GsTG +G++ + v++++ p+++ ++va++  +
       EFC38248.1 53 IVVGSTGLVGKNVVRVLSQQnPQEYaKIVAISRRK 87
                     699*************9865455553899998755 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 3.4
                      HHHHHHHHHHT-SEE CS
  DXP_reductoisom  37 ellaeqakefkpklv 51 
                      ++++++a++++ + +
       EFC38248.1 271 KAMLQIAATTRQQKL 285
                      334444433333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1010  (0.0563333); expected 358.6 (0.02)
Passed bias filter:                      647  (0.0360868); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.67u 0.35s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 1871.40
//
Query:       EFC38249.1  [L=884]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   4.6e-116  388.4  11.0   5.9e-116  388.1  11.0    1.1  1  Adaptin_N        Adaptin N terminal region
    2.4e-21   76.0   0.0    7.5e-21   74.4   0.0    1.9  1  Alpha_adaptin_C  Alpha adaptin AP2, C-terminal domain
      1e-11   45.1   0.0      3e-11   43.6   0.0    1.8  1  Alpha_adaptinC2  Adaptin C-terminal domain
    2.8e-06   27.6   0.8        1.9    8.9   0.0    4.0  4  HEAT_2           HEAT repeats
    0.00067   19.7   0.3        2.7    8.5   0.1    3.9  3  HEAT             HEAT repeat
     0.0019   18.3   0.1      0.067   13.3   0.0    3.0  3  Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendag
  ------ inclusion threshold ------
      0.038   14.6   0.6       0.47   11.1   0.4    3.0  3  Vac14_Fab1_bd    Vacuolar 14 Fab1-binding region
      0.046   13.8   0.3       0.42   10.7   0.3    2.4  1  B2-adapt-app_C   Beta2-adaptin appendage, C-terminal sub-doma
      0.073   13.5   0.3        9.5    6.7   0.0    3.2  2  RasGEF_N_2       Rapamycin-insensitive companion of mTOR RasG
      0.074   13.2   1.2       0.23   11.6   0.4    2.3  2  RTP1_C1          Required for nuclear transport of RNA pol II


Domain annotation for each model (and alignments):
>> Adaptin_N  Adaptin N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  388.1  11.0  3.3e-119  5.9e-116       2     523 ..      23     587 ..      22     588 .. 0.95

  Alignments for each domain:
  == domain 1  score: 388.1 bits;  conditional E-value: 3.3e-119
                 HHHCCHHHHHHCCSSS.....-SCHHHHHHHHHHHHHHHCT---GHHHHHHHCCCCSS-CHHHHHHHHHHHHHCTTSCCHHCCCCHHHHHHCCSSSHHH CS
   Adaptin_N   2 ekriqqelaeilnsnk.....dddekkkeavkkliylialGedvsflffevvklvaskdfelKrlvYlylellaeesedlalLvtnslqkDlkdpnqli 95 
                 ++ +++ela+i+ ++k     +++ +kk +++kl+y+++lG++++f+++e v+l+as ++++K ++Yl+ +ll++e++++++L+t+++++Dl+++n++ 
  EFC38249.1  23 QSKVEKELAKIRGKFKnggalKGYDRKK-YICKLLYIYMLGYEIEFGHIEAVNLLASPNYSEKHMGYLACSLLLNENHEMVTLITQCMKNDLNSKNPND 120
                 67899*************9966666666.********************************************************************** PP

                 HHHHHHHHCCC--CCCHHHHHHHHHHHHT-SSH..HHHHHHHHHHHHCCCCCHHCCCCC.HHHHHHHCTT-SSHHHHHHHHHHHHHH.HCCCCCCCHHH CS
   Adaptin_N  96 rglALrvLssirvpelaedlapaikkllkdrsp..yvrkkAalailklykkdpdllrkq.lveeikellsdkdpgvvlaAvalleei.kkndrlllkll 190
                 ++lAL+++++i+ +e ae+la++++kll + ++   vrkkAal++l l +k+p+ l+++ + e+++ l++ +d gv++++ +l+  + +kn++++ +++
  EFC38249.1 121 QCLALTAIANIGGKEQAEALAHDVQKLLISNETklTVRKKAALTLLNLHRKYPESLPPDsWSEKVIALINGRDLGVITSVMSLILGLaEKNPEAYQDAV 219
                 ****************************9999989***********************************************************99*** PP

                 HHHHCCHHHHH............HCS-HHHHHHHHHHHCC---SSHHHH..HHHHHHHCGGCG................CSSCHHHHHHHHHCCHCCCC CS
   Adaptin_N 191 pklvrrLcnll............teldpwlqvkiiklltrlarqepeerskkellesllnllq................ssnnaVlletvnlivelapk 261
                 +k +r L +l+            ++  pwlqvk  +ll+ +   e+++   +++++ +++ +q                +++ +Vl+e+ nl+++++++
  EFC38249.1 220 SKTARLLMKLVlnreystsylyyKIAAPWLQVKAFQLLQYYPVPEDKAIY-DSIIQAIEKVIQiakkskettsksvsqiNAAHSVLFEAMNLAIHYDSS 317
                 **************************************988775555554.89********************************************** PP

                 STHHHCCHHCHHHHHHSSCCTCHHHHHCHHHHHHHHX....XTTTT.TTTCCCCSXXTTSXHHHHHHHHHHHCCCXXTTTHHHHHHHHHHHTTSSXXHH CS
   Adaptin_N 262 nelivlavnaLvrllsskdenlryvaLrtllkivkke....pkavq.hldlkifllktdddvsirlkaldlllklvdesNvkeivkeLkkyvkevaded 355
                  +++v a++ L + l+++++nlry+aL+tl++++ ++      +++ ++d+++  lk d+d+sir++aldll+ +++++N+ eiv eL++y+  ++d+ 
  EFC38249.1 318 KTILVTACSMLTKYLKDRETNLRYLALDTLSRMAYSQfdevLATIRkEQDTILLALK-DPDISIRRRALDLLYSMCNRDNAGEIVGELLNYL-PLSDYA 414
                 ************************************97777778889**********.**********************************.****** PP

                 HHHHHHHHHHHHHHHSCCHHHHHHHHHHHHHTTXXHHHHHHHHHHHHHHHHHS.TTTSTTCHHHHCCTCCG.XXSHHHHHHHHHHHHHTTTTXTT.... CS
   Adaptin_N 356 fksklvkaIgrlaekfatdaewvldvllellslsgesvkdeivevirdliqkv.pelheeiiekLaellek.ieseearaaaiWllGeygelvsn.te. 450
                 ++++lv +I++laekf  d +w++dv+l+l+s +g++v+d+i+++++++++++ +el+++++++++ ++++  ++e+ ++   +++Ge+g+l+ +  + 
  EFC38249.1 415 IREELVLKIAILAEKFSVDLTWYVDVVLNLISQAGDFVADDIWHRVIQIVTNKgEELQKYTAQTVFSAVSSpAAHETCVKISGYIFGEFGDLIADnPQt 513
                 *************************************************98874789*************************************97567 PP

                 .HHHHHHCTTTTTTTSXHHHHHHHHHHHHHHHHCXGCC..THXHHHHHHHHHHHXXSHHHHHHHHHHHHHHCCX CS
   Adaptin_N 451 sasdllrslaekfvlesekvklqiltalvKlyltspdke.tqekliqlvlslatssdlevrdRaveylqllssa 523
                 +a ++ +++++kf l+s+++k+ + ++l+Kly++ pd++  ++++++++++ ++s d e+++R+ eyl l++++
  EFC38249.1 514 DAFSQYELILSKFNLCSTTTKCHLFNSLMKLYNLYPDNQgLRDNIKDVFEKHTNSFDAELQQRSAEYLALINTG 587
                 999999****************************997441556***************************9986 PP

>> Alpha_adaptin_C  Alpha adaptin AP2, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.4   0.0   4.2e-24   7.5e-21       8     112 ..     774     875 ..     766     876 .. 0.87

  Alignments for each domain:
  == domain 1  score: 74.4 bits;  conditional E-value: 4.2e-24
  Alpha_adaptin_C   8 ssedFfkrWkqlggapreaqkifklkaaekeideetvrkvl.eGfrlavlenvdpnpenivgagvlhtsesgkvgcLlrlepNkqakmvrltiR 100
                       +e+Ffk+W+ +g +++e+qkif  +      d +   kvl eGfrla+l+++d np+niv+ag +  +  gkv++Llrle N+ ++ +rlt++
       EFC38249.1 774 GAENFFKQWHAIG-KEQEVQKIFPCTPV--YSDVNACAKVLsEGFRLAILTGID-NPSNIVAAGSFFYDPVGKVNVLLRLEYNAPKQAYRLTVK 863
                      4899********7.778*******6644..4556667777779**********9.89************************************* PP

  Alpha_adaptin_C 101 atkeavpktllk 112
                      a+++++++++ +
       EFC38249.1 864 AQDATIAQQVFN 875
                      ********9875 PP

>> Alpha_adaptinC2  Adaptin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.6   0.0   1.7e-14     3e-11       1      96 [.     657     747 ..     657     752 .. 0.92

  Alignments for each domain:
  == domain 1  score: 43.6 bits;  conditional E-value: 1.7e-14
                      SEEEEEEETTEEEEEEEEETTSTTEEEEEEEEEE-SSS-EEEEEEEEEEBTTCEEEEEEES-S-B-TTCEEEEEEEEEEESCTTS-EEEEEEEE CS
  Alpha_adaptinC2   1 pevvlyekddlqIgfkfekperpgqiritlsftNkssqpisnfsfqaavpkslklqlqppsstvlppnpggqitqvllienpskkplrmrlris 94 
                      +e+v+ e+ +lq+ +k e+  ++ ++r+ l ++Nk+++p+++f+  + vpk+l+ q++     + p   ++q++q + +++++++++   l++ 
       EFC38249.1 657 NEGVAIEDEHLQVKIKTEY--HGCKGRLILLYGNKTTNPLTQFKVHILVPKELEAQISKVPPMISP---KTQVQQYVDLVAKGPFSQLTDLDLY 745
                      5799***************..********************************9999999999999...9*********999999888877776 PP

                      EE CS
  Alpha_adaptinC2  95 yk 96 
                      ++
       EFC38249.1 746 FE 747
                      65 PP

>> HEAT_2  HEAT repeats
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0      0.01        18       8      59 ..     113     169 ..     107     178 .. 0.68
   2 !    8.3   0.0    0.0016       2.9      32      71 ..     324     363 ..     307     369 .. 0.82
   3 !    8.9   0.0    0.0011       1.9       6      57 ..     371     425 ..     366     434 .. 0.84
   4 ?   -1.6   0.0       2.1   3.8e+03      10      36 ..     567     595 ..     560     600 .. 0.64

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.01
      HEAT_2   8 lendpdpevrraairaLgrignpea....lpaLvell.ed.edpavRraaaeaLgaig 59 
                 l n+++p+ +  a+ a+++ig +e        + +ll ++ ++  vR+ aa +L  + 
  EFC38249.1 113 L-NSKNPNDQCLALTAIANIGGKEQaealAHDVQKLLiSNeTKLTVRKKAALTLLNLH 169
                 5.78999999999999998876543122255556777755145689999999887664 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0016
      HEAT_2  32 alpaLvellededpavRraaaeaLgaigdpealpaLkell 71 
                 a  +L+++l+d +++ R+ a ++L++++ +++ ++L+ + 
  EFC38249.1 324 ACSMLTKYLKDRETNLRYLALDTLSRMAYSQFDEVLATIR 363
                 6778999999999999999999999999988888887754 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0011
      HEAT_2   6 qalendpdpevrraairaLgrignp....ealpaLvellededpavRraaaeaLga 57 
                  al +dpd  +rr+a++ L ++ n+    e++  L+++l  +d a+R++ +  ++ 
  EFC38249.1 371 LAL-KDPDISIRRRALDLLYSMCNRdnagEIVGELLNYLPLSDYAIREELVLKIAI 425
                 457.9***************88777677799****************999876655 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 2.1
      HEAT_2  10 ndpdpevrraairaLg..rignpealpaL 36 
                 n+ d e++++ ++ L+  + g++++++a+
  EFC38249.1 567 NSFDAELQQRSAEYLAliNTGDEDLIQAV 595
                 56667777777777774444566666655 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.39   7.1e+02      14      27 ..     155     168 ..     144     172 .. 0.75
   2 ?    5.2   0.0     0.017        30       4      28 ..     327     351 ..     325     354 .. 0.91
   3 !    8.5   0.1    0.0015       2.7       5      28 ..     369     392 ..     366     394 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.39
                 HHHHHHHHHHHHHH CS
        HEAT  14 peVReaAakaLgal 27 
                   VR+ Aa++L +l
  EFC38249.1 155 LTVRKKAALTLLNL 168
                 46********9877 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.017
                 HHHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   4 lllkllsDpspeVReaAakaLgala 28 
                 +l k l+D + + R+ A+ +L ++a
  EFC38249.1 327 MLTKYLKDRETNLRYLALDTLSRMA 351
                 68999*****************998 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0015
                 HHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   5 llkllsDpspeVReaAakaLgala 28 
                 +l +l+Dp+ ++R+ A+  L  ++
  EFC38249.1 369 ILLALKDPDISIRRRALDLLYSMC 392
                 66679***************9998 PP

>> Coatomer_g_Cpla  Coatomer subunit gamma-1 C-terminal appendage platform
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1      0.37   6.6e+02      34      71 ..     269     306 ..     264     324 .. 0.87
   2 ?   -0.9   0.0      0.96   1.7e+03      14      67 ..     567     618 ..     556     643 .. 0.63
   3 !   13.3   0.0   3.7e-05     0.067       9     114 ..     775     876 ..     765     877 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.37
                      ---HHHHHHHHHHHHT-EE-TTTT---SS-SEEEEEEE CS
  Coatomer_g_Cpla  34 vksleeavdkliellgmqplegsdkvpenassHtLkla 71 
                      ++s+ +a++k+i++   +    s+ v++ +++H++++ 
       EFC38249.1 269 YDSIIQAIEKVIQIAKKSKETTSKSVSQINAAHSVLFE 306
                      678899999***99999999999999999999998875 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.96
                      HHHHHH-STT-EEEEEEESS---HHHHHHHHHHHHT-EE-TTTT---SS-SEEE CS
  Coatomer_g_Cpla  14 aaWeeleseaeavetfaLssvksleeavdkliellgmqplegsdkvpenassHt 67 
                      +++++  + + ++e  aL + +  e+ ++++++++ m+p   s++ ++  ++  
       EFC38249.1 567 NSFDAELQ-QRSAEYLALIN-TGDEDLIQAVMDNMPMYPERDSQVIKRLMEKEA 618
                      55554444.24555556633.4558899999*******9999997766555555 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 3.7e-05
                      -S-HHHHHHHH-STT-EEEEEEE.SS---HHHHHHHHHHHHT-EE-TTTT---SS-SEEEEEEEEEETTS-..EEEEEEEEEE..SS.EEEEEE CS
  Coatomer_g_Cpla   9 vsnFeaaWeeleseaeavetfaL.ssvksleeavdkliellgmqplegsdkvpenassHtLklaGkfvgge..kvlvrarlalssskgvtlklt 99 
                      ++nF ++W ++++e+e+ + f     ++++++ ++ l e + +  l g d +p+n     +  aG f+ +   kv v +rl +++  + + +lt
       EFC38249.1 775 AENFFKQWHAIGKEQEVQKIFPCtPVYSDVNACAKVLSEGFRLAILTGID-NPSN-----IVAAGSFFYDPvgKVNVLLRLEYNA-PKQAYRLT 861
                      349*******************955567777777778899*********9.6655.....7789999997777**********98.5579**** PP

                      EEESSHHHHHHHHHH CS
  Coatomer_g_Cpla 100 vRsedeevaelvlsa 114
                      v+++d+++a+ v + 
       EFC38249.1 862 VKAQDATIAQQVFNY 876
                      ************986 PP

>> Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       3.3   5.9e+03      47      76 ..     275     304 ..     273     317 .. 0.74
   2 ?   11.1   0.4   0.00026      0.47      12      88 ..     307     384 ..     295     392 .. 0.86
   3 ?   -1.5   0.0       2.2     4e+03      23      80 ..     451     510 ..     440     513 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3.3
  Vac14_Fab1_bd  47 acEslyniakvakgevlkllneifdalvkl 76 
                    a+E +  iak++k++  k +++i  a + l
     EFC38249.1 275 AIEKVIQIAKKSKETTSKSVSQINAAHSVL 304
                    789999999999988877777776555544 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00026
  Vac14_Fab1_bd  12 avaialekk.ikeyleeivkpvlkcfsDkdsrvRyyacEslyniakvakgevlkllneifdalvklvaDsdesvksga 88 
                    a+ +a++ + +k++l +  +++ k+++D+++ +Ry a ++l  +a    +evl ++ +  d++   + D d s+++ a
     EFC38249.1 307 AMNLAIHYDsSKTILVTACSMLTKYLKDRETNLRYLALDTLSRMAYSQFDEVLATIRKEQDTILLALKDPDISIRRRA 384
                    556666666567777888888999*************************************************99754 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 2.2
  Vac14_Fab1_bd  23 eyleeivkpvlkcfsDkdsrvRyyacEslyniak..vakgevlkllneifdalvklvaDs 80 
                     + ++i + v+++++ k +++  y++ +++  +   +a+++++k    if  +  l+aD+
     EFC38249.1 451 FVADDIWHRVIQIVTNKGEELQKYTAQTVFSAVSspAAHETCVKISGYIFGEFGDLIADN 510
                    456889999999999998888877777777654312455566666667777777777775 PP

>> B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.3   0.00024      0.42       9     108 ..     776     877 ..     774     880 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00024
  B2-adapt-app_C   9 eeFlekWkslpesneqsltlsnnvastspdaleekLqanniftiAkrgvegqqekl....YfsakltngilfLvellintsgksvkvsvKsedpe 99 
                     e+F ++W ++ +++e+++ ++ +++  +++a+ + L++     i   g +++ + +    +f+   + ++ +L+ l +n+++++++++vK++d++
      EFC38249.1 776 ENFFKQWHAIGKEQEVQKIFPCTPVYSDVNACAKVLSEGFRLAIL-TGIDNPSNIVaagsFFYD-PVGKVNVLLRLEYNAPKQAYRLTVKAQDAT 868
                     778888888888887777777755336777777777665433333.233333222212214444.567799********88845*********** PP

  B2-adapt-app_C 100 vaplflqll 108
                     +a+++++++
      EFC38249.1 869 IAQQVFNYI 877
                     ****99876 PP

>> RasGEF_N_2  Rapamycin-insensitive companion of mTOR RasGEF_N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.1     0.065   1.2e+02       7      36 ..     325     354 ..     308     371 .. 0.66
   2 ?    6.7   0.0    0.0053       9.5      12      45 ..     371     404 ..     366     432 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.065
  RasGEF_N_2   7 iellvnqLydqsrevvaaaleiLeeacddk 36 
                 +++l++ L+d +++ +  al+ L ++ +++
  EFC38249.1 325 CSMLTKYLKDRETNLRYLALDTLSRMAYSQ 354
                 556666666666666666666666665554 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0053
  RasGEF_N_2  12 nqLydqsrevvaaaleiLeeacddkeslevlvel 45 
                   L+d++ ++++ al++L+++c+ ++  e + el
  EFC38249.1 371 LALKDPDISIRRRALDLLYSMCNRDNAGEIVGEL 404
                 5799*******************99877776664 PP

>> RTP1_C1  Required for nuclear transport of RNA pol II C-terminus 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       8.3   1.5e+04      57      71 ..     269     283 ..     255     297 .. 0.56
   2 ?   11.6   0.4   0.00013      0.23       5      83 ..     329     408 ..     325     429 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 8.3
     RTP1_C1  57 YLnaikgLvaLadvf 71 
                 Y + i+++++++++ 
  EFC38249.1 269 YDSIIQAIEKVIQIA 283
                 444444444433333 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00013
     RTP1_C1   5 lkdlqdpllpvrahglvlLrkliekkskeavldiekilkllleaLkdedsYvYLnaikgLvaLadvfpe.evlklLleey 83 
                  k+l+d +  +r  +l +L++++ ++  e +++i+k  +++l aLkd+d  +   a  +L ++++++++ e++ +Ll++ 
  EFC38249.1 329 TKYLKDRETNLRYLALDTLSRMAYSQFDEVLATIRKEQDTILLALKDPDISIRRRALDLLYSMCNRDNAgEIVGELLNYL 408
                 6899************************************************************9985427777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (884 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       822  (0.0458475); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.85u 0.32s 00:00:01.17 Elapsed: 00:00:00.52
# Mc/sec: 5087.43
//
Query:       EFC38250.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3669  (0.204641); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.83u 0.39s 00:00:01.22 Elapsed: 00:00:00.54
# Mc/sec: 1963.78
//
Query:       EFC38251.1  [L=565]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      2e-34  119.2   2.4      2e-34  119.2   2.4    2.5  2  ELMO_CED12  ELMO/CED-12 family


Domain annotation for each model (and alignments):
>> ELMO_CED12  ELMO/CED-12 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.3      0.58     1e+04     133     151 ..      34      52 ..      19      57 .. 0.43
   2 !  119.2   2.4   1.1e-38     2e-34       4     177 .]     247     535 ..     244     535 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 0.58
  ELMO_CED12 133 lktnntkllssnlnafeel 151
                 +k++++k++s+++n+ ++ 
  EFC38251.1  34 KKSTKKKSSSKTKNQHNRT 52 
                 2223334444444444444 PP

  == domain 2  score: 119.2 bits;  conditional E-value: 1.1e-38
  ELMO_CED12   4 ekkrktpldlenpeherlLkelwsalypdepeinstksrisekWkklGFqgedPatDFrgtGlLgLenLlyfaenheeefqkllsessrrpsee..... 97 
                 +k ++ ++d en +h++lL +l+++++ ++++i       +e+Wk lGFq+++P tDFrg+G+LgL+nLlyf++++++ f++   +++++ s       
  EFC38251.1 247 KKYCSKKFDIENDKHQKLLFSLYKCCT-QKKTIL----TEGEHWKFLGFQNTKPETDFRGAGILGLRNLLYFSKHYKKRFKNYFGKCTNEISVTddgtf 340
                 788999******************999.667776....89*************************************************9995567889 PP

  ELMO_CED12  98 .eypfavasinvtsll..................................lelleiektdeedeeeqkdklkt.......................... 135
                  +ypf++a++nvt+ll                                  l                     +                          
  EFC38251.1 341 tSYPFVIAGLNVTMLLlsflgigfqaskvhnvtakknfielltsgrgkpvL---------------------Eededeeededstpvvtegtllsfddi 418
                 9***************66666666666666666666665555555554440.....................044444444555555666666666666 PP

  ELMO_CED12 136 ...........................................................................nntkllssnlnafeelfsvlfllf 159
                                                                                            ++t++ + nl+ f+e+++v f  +
  EFC38251.1 419 peqkpkkkginilddeispvvwdnnslswdepnsatssknvaagsntkkstagtklvpaspvkisqktekkkkpkAKTETHQFNLDLFNEMYVVGFTCL 517
                 666666666666666666666666666666666666666666666777777777777777777777777777787899999****************** PP

  ELMO_CED12 160 dslWkekkatimdfnkvl 177
                 +++W+++kat+ df++vl
  EFC38251.1 518 HREWHRTKATYFDFGRVL 535
                 ***************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (565 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1224  (0.0682693); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.76u 0.37s 00:00:01.12 Elapsed: 00:00:00.57
# Mc/sec: 3005.04
//
Query:       EFC38252.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.002   18.1   1.5        8.5    6.8   0.0    3.8  3  TPR_2     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.067   13.5   0.2        7.2    7.0   0.0    3.4  4  TPR_12    Tetratricopeptide repeat
       0.71   10.2   7.4         21    5.6   0.0    4.5  5  TPR_8     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.0    0.0063        38       4      27 ..     139     162 ..     137     166 .. 0.88
   2 !    6.8   0.0    0.0014       8.5      10      31 ..     204     225 ..     203     228 .. 0.89
   3 ?    3.0   0.1     0.023   1.4e+02       4      25 ..     262     283 ..     260     285 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0063
       TPR_2   4 lynlGlayyklgdyeeAleafekA 27 
                  +++G++  klg + +A++++e A
  EFC38252.1 139 IFYRGYSSHKLGLFTQAERDLEVA 162
                 599***************999855 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0014
       TPR_2  10 ayyklgdyeeAleafekAleld 31 
                  ++kl+++++ le+f k ++l 
  EFC38252.1 204 NHIKLKQFQQSLEYFIKLISLM 225
                 689************9999986 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.023
       TPR_2   4 lynlGlayyklgdyeeAleafe 25 
                 ++ l++ +yk++dy     +fe
  EFC38252.1 262 YFFLAEFLYKQQDYLSSNILFE 283
                 899***********76666665 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0     0.069   4.1e+02       9      31 ..      88     110 ..      79     117 .. 0.80
   2 ?   -2.1   0.0      0.84     5e+03       8      23 ..     148     163 ..     144     167 .. 0.52
   3 ?    7.0   0.0    0.0012       7.2       8      40 ..     200     230 ..     194     235 .. 0.81
   4 ?   -0.5   0.0      0.26   1.5e+03       9      24 ..     265     280 ..     262     284 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.069
      TPR_12   9 laavlrrlgrydeAlellekale 31 
                 l + +   g+yd+ +++  ++l+
  EFC38252.1  88 LVQSYSISGEYDKTIAYSTECLD 110
                 66778888999999999999987 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.84
      TPR_12   8 nlaavlrrlgrydeAl 23 
                 +l+++ ++  +++ A+
  EFC38252.1 148 KLGLFTQAERDLEVAE 163
                 4555555555555554 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0012
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpd 40 
                  l + + +l++++++le++ k + ++r++  +d
  EFC38252.1 200 TLINNHIKLKQFQQSLEYFIKLISLMRSA--TD 230
                 56777889*****************9988..55 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.26
      TPR_12   9 laavlrrlgrydeAle 24 
                 la++l+++++y  +  
  EFC38252.1 265 LAEFLYKQQDYLSSNI 280
                 89********976655 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1      0.71   4.3e+03       2      11 ..      59      68 ..      58      70 .. 0.56
   2 ?    5.1   0.0    0.0054        32       2      28 ..      83     109 ..      82     110 .. 0.90
   3 ?   -1.7   0.0      0.77   4.6e+03       8      25 ..     143     160 ..     142     165 .. 0.80
   4 ?    5.6   0.0    0.0035        21      11      30 ..     205     224 ..     203     226 .. 0.93
   5 ?   -0.6   0.3      0.35   2.1e+03       4      27 ..     262     285 ..     261     290 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.71
                CHHHHHHHHH CS
       TPR_8  2 eayynlgsiy 11
                +ayy ++  y
  EFC38252.1 59 KAYYGKATSY 68
                4556555555 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0054
                 CHHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekal 28 
                 ++ ++l + y+  g+y++ ++y  ++l
  EFC38252.1  83 QVIFLLVQSYSISGEYDKTIAYSTECL 109
                 5679999***************99998 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.77
                 HHHHHHTT-HHHHHHHHH CS
       TPR_8   8 gsiylklgdyeeAkeyye 25 
                 g+  +klg + +A+  +e
  EFC38252.1 143 GYSSHKLGLFTQAERDLE 160
                 677789999999988776 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.0035
                 HHHTT-HHHHHHHHHHHHHH CS
       TPR_8  11 ylklgdyeeAkeyyekalel 30 
                 ++kl++++++ ey+ k ++l
  EFC38252.1 205 HIKLKQFQQSLEYFIKLISL 224
                 689**************997 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 0.35
                 HHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyeka 27 
                 y+ l+  + k++dy ++   +ek+
  EFC38252.1 262 YFFLAEFLYKQQDYLSSNILFEKY 285
                 899999999999998887777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       970  (0.0541023); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.55
# Mc/sec: 1836.99
//
Query:       EFC38253.1  [L=698]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.3e-09   36.0  10.7    1.6e-08   34.5  10.7    1.9  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
       0.01   16.1   0.1      0.031   14.5   0.1    1.7  2  TPR_12    Tetratricopeptide repeat
      0.012   15.4   2.7      0.044   13.6   1.7    2.3  2  TPR_1     Tetratricopeptide repeat
      0.077   13.1   2.2       0.25   11.6   1.3    2.3  2  TPR_2     Tetratricopeptide repeat
       0.45   10.9   3.1        7.2    7.1   1.6    2.6  2  TPR_8     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5  10.7   4.4e-12   1.6e-08       2      38 ..     123     158 ..     122     161 .. 0.91

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 4.4e-12
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysessk 38 
                 +C++C++++++Cd+  PaCs C k+n+eC+ y+ ++k
  EFC38253.1 123 SCKRCKSRHTRCDRVLPACSYCLKNNFECM-YETPKK 158
                 8*****************************.776665 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.1   8.7e-06     0.031       3      40 ..     284     321 ..     275     330 .. 0.60
   2 ?   -3.3   0.0       3.3   1.2e+04      57      67 ..     362     372 ..     358     374 .. 0.62

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 8.7e-06
      TPR_12   3 atalnnlaavlrrlgrydeAlellekaleiarrllGpd 40 
                 a ++   a++l+  +++ eA+e+++k+++i +   + +
  EFC38253.1 284 ALMYASQALILYFKEEWREAEEYYNKCIQILEDETESN 321
                 33443466666666666666666666666666555555 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 3.3
      TPR_12  57 algryeeAlel 67 
                  +g+++eA+++
  EFC38253.1 362 SMGDLKEAVKF 372
                 56777777654 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   1.7   1.2e-05     0.044       4      31 ..     287     314 ..     284     317 .. 0.88
   2 ?   -0.6   0.0      0.38   1.4e+03      13      23 ..     362     372 ..     357     374 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.2e-05
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   4 lynlGnayfklgkydeAleyyekALeln 31 
                 +   +++++ ++++ eA+eyy+k++++ 
  EFC38253.1 287 YASQALILYFKEEWREAEEYYNKCIQIL 314
                 777899********************96 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.38
                 HTT-HHHHHHH CS
       TPR_1  13 klgkydeAley 23 
                 ++g+++eA+++
  EFC38253.1 362 SMGDLKEAVKF 372
                 79******985 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   1.3   6.9e-05      0.25       6      31 ..     289     314 ..     284     317 .. 0.88
   2 ?   -0.9   0.0      0.66   2.4e+03      13      24 ..     362     373 ..     356     376 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.9e-05
       TPR_2   6 nlGlayyklgdyeeAleafekAleld 31 
                  ++l++y + ++ eA+e+++k++++ 
  EFC38253.1 289 SQALILYFKEEWREAEEYYNKCIQIL 314
                 5799*******************986 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.66
       TPR_2  13 klgdyeeAleaf 24 
                  +gd++eA+++ 
  EFC38253.1 362 SMGDLKEAVKFV 373
                 689*****9975 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   1.6     0.002       7.2       4      30 ..     287     313 ..     284     315 .. 0.85
   2 ?    2.2   0.0     0.077   2.7e+02      12      26 ..     361     375 ..     356     377 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.002
                 HHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekalel 30 
                 y   ++i+  +++  eA+eyy+k++++
  EFC38253.1 287 YASQALILYFKEEWREAEEYYNKCIQI 313
                 777788888888889**********86 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.077
                 HHTT-HHHHHHHHHH CS
       TPR_8  12 lklgdyeeAkeyyek 26 
                 l++gd++eA+++ + 
  EFC38253.1 361 LSMGDLKEAVKFVRL 375
                 689*******99776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (698 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1074  (0.059903); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.81u 0.35s 00:00:01.16 Elapsed: 00:00:00.57
# Mc/sec: 3717.17
//
Query:       EFC38254.1  [L=1609]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.3e-32  110.5   0.4    4.6e-31  107.8   0.1    2.5  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    4.4e-15   55.8   0.2    1.2e-14   54.4   0.2    1.8  1  PAS_9          PAS domain
    3.6e-08   33.4   0.0    1.1e-07   31.9   0.0    1.9  1  PAS            PAS fold
  ------ inclusion threshold ------
      0.052   13.8   0.0      0.096   12.9   0.0    1.4  1  PAS_4          PAS fold
      0.084   12.3   1.3       0.16   11.4   0.0    2.1  2  HNOBA          Heme NO binding associated


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.35   1.2e+03      89     106 ..     592     610 ..     581     618 .. 0.81
   2 !  107.8   0.1   1.3e-34   4.6e-31       3     126 ..    1480    1609 .]    1478    1609 .] 0.96

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.35
  Guanylate_cyc  89 l.eevaveskeglkvrvGi 106
                    + e++++e+ e++ vr+Gi
     EFC38254.1 592 MqENINHEKCESIIVRIGI 610
                    3478888899********9 PP

  == domain 2  score: 107.8 bits;  conditional E-value: 1.3e-34
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp..eekaahaaklaelaLdmlealeevav 94  
                     ae++++v+ +F+d+vgft+ls+  ++ e+v++Lne++  fd+l+d+++++k+ktiGd+y +v gl+  +++ +h ++++++++d ++ l+ ++ 
     EFC38254.1 1480 AEKFNDVSCFFSDMVGFTKLSTGIQASELVQMLNEIVIGFDDLTDKYNLEKIKTIGDSYFCVGGLHglNAQSDHPERILRFSIDTFDVLQRFNS 1573
                     68899**************************************************************99************************9 PP

  Guanylate_cyc   95 es....keglkvrvGihtGpvvagviGakkprydvw 126 
                     +s    +e++++rvGi+tG+v+agviG+kk+ y  +
     EFC38254.1 1574 KSgkqpSEQINIRVGINTGSVIAGVIGRKKFAYVCF 1609
                     9977777************************99765 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.4   0.2   3.4e-18   1.2e-14       7     104 .]    1341    1441 ..    1334    1441 .. 0.93

  Alignments for each domain:
  == domain 1  score: 54.4 bits;  conditional E-value: 3.4e-18
       PAS_9    7 dnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.......kerevevvlirkngetfwvlltaspvkdddgelvgii 96  
                    ++  i+ +N+aa +++Gy+  e +g+s+ +lf  +++++++++++++++         k  + e+++irkn++ f+ ++++++   +++ +v   
  EFC38254.1 1341 SGEKVDIEIFNPAAQKIFGYNQTETIGRSLYQLF--EKNEQSKIKNLIDEMLVnaargdsKGDSIELECIRKNQTSFPSRVNIFATLHNSQSVVT-- 1433
                  555557999*************************..***********************************************************.. PP

       PAS_9   97 vilrDite 104 
                  ++++Dit+
  EFC38254.1 1434 CFIKDITT 1441
                  ******95 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.9   0.0     3e-11   1.1e-07       3     113 .]    1326    1439 ..    1324    1439 .. 0.95

  Alignments for each domain:
  == domain 1  score: 31.9 bits;  conditional E-value: 3e-11
                  HHHHHHHSSSEEEEEE.TTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEEE CS
         PAS    3 lraileslpdpifvvD.edgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevras 94  
                  +r+il+++ d+ ++   e+ +i  +N+aa++++G+++ e +g+sl+ l+  +++++ + l+ + l ++ ++ ++  s++l    ++++ ++ +v+  
  EFC38254.1 1326 VRSILNASVDGAVMCSgEKVDIEIFNPAAQKIFGYNQTETIGRSLYQLFEKNEQSKIKNLIDEMLVNAARGDSKGDSIELecirKNQTSFPSRVNIF 1422
                  78999**9999999999999**********************************************************9999999************ PP

                  EEEETTEEEEEEEEEEEES CS
         PAS   95 pvrdaggeilgflgvlrdi 113 
                   +++ ++    + ++++di
  EFC38254.1 1423 ATLHNSQS--VVTCFIKDI 1439
                  ****9998..89***9998 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   2.7e-05     0.096       1      60 [.    1330    1390 ..    1330    1397 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.7e-05
       PAS_4    1 ldslpdalavl.dpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvl 60  
                  l+++ d+ +++ ++   ++  N+aa+++fg+ + e +G++l++l+ +  +  + + ++++l
  EFC38254.1 1330 LNASVDGAVMCsGEKVDIEIFNPAAQKIFGYNQTETIGRSLYQLFEKNEQSKIKNLIDEML 1390
                  57888888888899999999***************************99999999888877 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.3      0.91   3.3e+03      75     115 ..     656     673 ..     615     734 .. 0.59
   2 ?   11.4   0.0   4.4e-05      0.16     193     221 .]    1444    1472 ..    1428    1472 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.91
       HNOBA  75 kkksikeeeaeknseklqasaeeartdlkekkredrnvkks 115
                 ++++i+ee+++++++++                       +
  EFC38254.1 656 EATTIEEEDSKRMNASS-----------------------K 673
                 11111111111111111.......................1 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 4.4e-05
       HNOBA  193 esmkeleeekkrtdeLLysmiPkevAerL 221 
                  + ++ l eekk ++eLL +++P  vA++L
  EFC38254.1 1444 KHNSLLTEEKKHSEELLLNILPSAVASKL 1472
                  667789********************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1609 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1729  (0.0964359); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.11u 0.32s 00:00:01.43 Elapsed: 00:00:00.56
# Mc/sec: 8585.76
//
Query:       EFC38255.1  [L=110]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-05   24.6   0.0    2.5e-05   24.0   0.0    1.3  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   1.4e-09   2.5e-05     136     182 ..       1      46 [.       1      47 [. 0.95

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 1.4e-09
  Guanylate_cyc 136 mestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182
                    mes++ +g+iq+s++tye   + +f+++er + +vkGkg+ ++y+l+
     EFC38255.1   1 MESNSIPGRIQISRSTYERVYDLGFTFEER-HLNVKGKGECIAYMLH 46 
                    9**************************998.69************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (110 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       432  (0.024095); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.53
# Mc/sec: 628.73
//
Query:       EFC38256.1  [L=209]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.056   13.3   2.4      0.065   13.1   1.1    1.8  2  ODV-E18       Occlusion-derived virus envelope protein ODV-E1
       0.11   12.6   0.1       0.17   12.0   0.1    1.2  1  Thioesterase  Thioesterase domain
       0.17   11.8   0.0        2.3    8.1   0.0    2.2  2  ZFYVE21_C     Zinc finger FYVE domain-containing protein 21 C


Domain annotation for each model (and alignments):
>> ODV-E18  Occlusion-derived virus envelope protein ODV-E18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   1.1   1.1e-05     0.065      25      56 ..       4      34 ..       1      41 [. 0.77
   2 ?   -3.6   0.0       1.8   1.1e+04      56      66 ..      66      76 ..      62      79 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.1e-05
     ODV-E18 25 sllltilvvlviiillvllvqssstGsdssss 56
                 lllt+l+vlv+i+ +v   q s+ Gs s  s
  EFC38256.1  4 GLLLTLLAVLVVIVAVV-HAQQSTCGSLSNNS 34
                589********998766.56666669877665 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.8
     ODV-E18 56 snannartGfv 66
                 ++n   tGfv
  EFC38256.1 66 QGTNRKATGFV 76
                57888888887 PP

>> Thioesterase  Thioesterase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   2.8e-05      0.17     194     217 ..      35      65 ..      18      74 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.8e-05
                   H.......CHCTCESCEEEEEESSHCCHHHS CS
  Thioesterase 194 r.......weqktsgevsvhvlegdhfylle 217
                   r       w++++sg++ ++v++g+hf+ ++
    EFC38256.1  35 RyinlvgsWRETSSGKIWTSVQQGNHFTWTQ 65 
                   13344444********************998 PP

>> ZFYVE21_C  Zinc finger FYVE domain-containing protein 21 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.027   1.6e+02      18      45 ..      15      42 ..       6      78 .. 0.58
   2 ?    8.1   0.0   0.00039       2.3      10      54 ..      55     103 ..      49     109 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.027
                E--SS--S-EEEEEEE-TTSSEEEEESS CS
   ZFYVE21_C 18 vtlgeseksetmvCrLssnqrfllldgd 45
                v +   +  +++   Ls+n r++ l g 
  EFC38256.1 15 VIVAVVHAQQSTCGSLSNNSRYINLVGS 42
                4444444445545589******999433 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00039
                 HHH-EEEEE--SS--S-EE....EEEEE-TTSSEEEEESSSEEEEETTT CS
   ZFYVE21_C  10 LlsGatfsvtlgesekset....mvCrLssnqrfllldgdshaevelsr 54 
                  ++G  f+ t++ +++  t      C++s+   ++ +dg +h +v +s+
  EFC38256.1  55 VQQGNHFTWTQQGTNRKATgfvvAPCQISTAVAYITFDGSTHWKVSISS 103
                 5788888888777777666666678********************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (209 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       788  (0.0439511); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1188.15
//
Query:       EFC38257.1  [L=215]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       397  (0.0221429); expected 358.6 (0.02)
Passed bias filter:                      301  (0.0167884); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.35s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 1224.90
//
Query:       EFC38258.1  [L=127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    8.6e-21   73.9   0.2    1.1e-20   73.5   0.2    1.2  1  Cyt-b5      Cytochrome b5-like Heme/Steroid binding domain
  ------ inclusion threshold ------
      0.015   15.3   0.1      0.034   14.2   0.1    1.5  1  EFP_N       Elongation factor P (EF-P) KOW-like domain
       0.12   11.2   0.1       0.12   11.1   0.1    1.0  1  Amnionless  Amnionless


Domain annotation for each model (and alignments):
>> Cyt-b5  Cytochrome b5-like Heme/Steroid binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.5   0.2   1.9e-24   1.1e-20       1      73 [.       6      78 ..       6      79 .. 0.93

  Alignments for each domain:
  == domain 1  score: 73.5 bits;  conditional E-value: 1.9e-24
                EHHHHTTTE.CTTEEEEEETTEEEECTTTCCCSTTCSHHHHTTTTSBBHHHHHHTTGGCHHHHHHHHGGEEEEE CS
      Cyt-b5  1 tleelskhn.gkndlwvairgkVYDvskflskhpGgesailkyaGkDateafksvvhsekdaekllkkylvGkl 73
                t++el++h+ +++d w+a++gkVY ++++ ++hpGge+++l++aG Da+eaf++v hs++ a++ lk++lvG+l
  EFC38258.1  6 TKKELEEHDeNHKDQWIAVDGKVYTITEYKHEHPGGEDILLEHAGADASEAFENVGHSKD-ARNKLKSLLVGEL 78
                789******5555******************************************99999.7888899****98 PP

>> EFP_N  Elongation factor P (EF-P) KOW-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.1   5.7e-06     0.034       7      30 ..      18      41 ..      15      43 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 5.7e-06
                TT-EEEETTEEEEEEEEEEEEETT CS
       EFP_N  7 kGlvieidgklyvVlefehvkpGk 30
                k + i +dgk+y++ e++h +pG+
  EFC38258.1 18 KDQWIAVDGKVYTITEYKHEHPGG 41
                66889*****************97 PP

>> Amnionless  Amnionless
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   2.1e-05      0.12     284     369 ..      36     122 ..       4     127 .] 0.69

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 2.1e-05
  Amnionless 284 ssdeeiqivildpekgsyaerlaqel..ladiaehgealgilsaeletsgasssdssaag.apgesaglvlgivfglvlllllllilll 369
                 ++++  + ++l+ ++g +a +  +++  ++d+++++++l + + e  +s++++ ++s++  ++++s+++v+ i++gl +++++++ +++
  EFC38258.1  36 HEHPGGEDILLE-HAGADASEAFENVghSKDARNKLKSLLVGELEGYKSSGAKDEVSSSTtTSASSGSSVMPIIVGL-VAVVIAAGVYF 122
                 456666667888.7888888887776335788888888888888888888888887766678888999999999999.44444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       941  (0.0524848); expected 358.6 (0.02)
Passed bias filter:                      668  (0.0372581); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.53u 0.34s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 738.27
//
Query:       EFC38259.1  [L=449]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0077   15.6   3.3     0.0077   15.6   3.3    5.3  6  DUF3450         Protein of unknown function (DUF3450)
  ------ inclusion threshold ------
        1.2    9.3  65.3      0.016   15.4  24.1    4.6  5  ATG16           Autophagy protein 16 (ATG16)
        2.2    6.5  68.4        4.6    5.5  68.3    1.5  1  MAD             Mitotic checkpoint protein


Domain annotation for each model (and alignments):
>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   3.3   1.3e-06    0.0077      15     100 ..      60     145 ..      49     149 .. 0.86
   2 ?   -2.2  12.4      0.33     2e+03      12      77 ..     141     206 ..     137     220 .. 0.75
   3 ?   -0.2   2.2     0.083     5e+02      31      58 ..     228     255 ..     206     290 .. 0.57
   4 ?   -0.7   5.8      0.12   7.4e+02      47      89 ..     279     321 ..     265     324 .. 0.70
   5 !    5.5   2.5    0.0016       9.4      51     105 ..     347     401 ..     338     406 .. 0.72
   6 ?   -1.5   0.1      0.21   1.2e+03      46      79 ..     405     438 ..     399     442 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.3e-06
     DUF3450  15 aatldqalkeaekavaaaaqsqkkidklddekqellaeyralkeeleslevyneqlerlvasqeqeiasleeqieeieeierelvp 100
                  +t + + k++ k   aa  +++k+++++ e+++l+ e  +l++e+++ +++  + e+++++ e++++ ++++ +e + i ++l+ 
  EFC38259.1  60 TSTRKPMSKTSVKDAVAAHVIETKVQEMESERRKLSLECDTLRSENKWYRKKLTETEHSLKTTEEKFETIKKSFDEQQVILSSLEK 145
                 456666777888888899999*****************************************************999988777765 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.33
     DUF3450  12 galaatldqalkeaekavaaaaqsqkkidklddekqellaeyralkeeleslevyneqlerlvasq 77 
                 ++l++tl +++k+++k +++++q     ++ +de  +l +++++ ++++++le++ e+l++++ + 
  EFC38259.1 141 SSLEKTLCDTKKKEKKRQQKQEQKKLLLQQTSDEVITLREKLERKETRAKALEIEAEYLQKQLGEI 206
                 455677778888888888888888888888888888888888888888888888888888887554 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.083
     DUF3450  31 aaaqsqkkidklddekqellaeyralke 58 
                 ++ ++q +++ l++ek++++ e+ +lk 
  EFC38259.1 228 EKDMAQDRVKTLEKEKEKVEHELFELKI 255
                 3334444444444444444444444444 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.12
     DUF3450  47 qellaeyralkeeleslevyneqlerlvasqeqeiasleeqie 89 
                 + l  e  + ke+++ le +  +++r  ++q q+i++l+++++
  EFC38259.1 279 NILTVENSSFKEKISFLEQKLLKYKRNAKQQSQTIEKLQQKQK 321
                 4455555666777777888888888888888888888888776 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.0016
     DUF3450  51 aeyralkeeleslevyneqlerlvasqeqeiasleeqieeieeierelvpllekm 105
                 + +++l++el+sle +n+ql+++++   +  ++  e  ee+ + +++l+ +l +m
  EFC38259.1 347 ETITSLNSELDSLEDKNRQLRAQLEYYASHAHNHSEYNEELLRENQNLKNILSEM 401
                 5567777777777777777777777777777777777777777777777777776 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 0.21
     DUF3450  46 kqellaeyralkeeleslevyneqlerlvasqeq 79 
                 +++ ++++r l++ele  +v+ e+ ++ ++++++
  EFC38259.1 405 RAKDEQRVRMLERELEIRDVEIEKRNKFIRKMNE 438
                 6677899999999999999999999998888775 PP

>> ATG16  Autophagy protein 16 (ATG16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4  24.1   2.7e-06     0.016      58     184 ..      61     199 ..      42     203 .. 0.73
   2 ?    3.5   5.2     0.013        75      77     146 ..     209     278 ..     200     289 .. 0.85
   3 ?   -0.9  11.1      0.28   1.6e+03      93     178 ..     267     367 ..     262     369 .. 0.72
   4 ?    2.4   9.2     0.027   1.6e+02     111     178 ..     342     416 ..     338     418 .. 0.48
   5 ?    5.9   3.5    0.0022        13      72     131 ..     380     439 ..     374     446 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.7e-06
       ATG16  58 akekeasasq............snskqsakiqsleqklaqlreelaelyksrgelaqrllelneelqkleeklkedeerlaeleaeraaletklkdree 144
                 +++k+ s+++            + ++ +++  +l+ ++ +lr+e +   k+ +e++ +l++++e+ ++ +++  e++  l +le++  + ++k k+r++
  EFC38259.1  61 STRKPMSKTSvkdavaahvietKVQEMESERRKLSLECDTLRSENKWYRKKLTETEHSLKTTEEKFETIKKSFDEQQVILSSLEKTLCDTKKKEKKRQQ 159
                 11111111112334433345555556666666777777777777777778888888888888888888888888888889999999999999999**** PP

       ATG16 145 elrekeklvqdlqDElsaLqlqlnqaEeklrklekENkeL 184
                 + ++k+ l+q+  DE+++L+ +l+  E + + le E++ L
  EFC38259.1 160 KQEQKKLLLQQTSDEVITLREKLERKETRAKALEIEAEYL 199
                 *********************************9998755 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.013
       ATG16  77 qsleqklaqlreelaelyksrgelaqrllelneelqkleeklkedeerlaeleaeraaletklkdreeel 146
                 ++l++kl q  ++l +   ++   ++r+++l++e +k e +l e + r+++   + +  +++  d++ ++
  EFC38259.1 209 KNLDDKLRQYESDLYNERLEKDMAQDRVKTLEKEKEKVEHELFELKIRVEKSYGDLEFCKKRETDHNSQI 278
                 78999***********************************999999999988887777777777777666 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.28
       ATG16  93 lyksrgelaqrllelneelqkleeklkedeerlaeleaeraaletklkdreeelrekeklvq..............dlqDE.lsaLqlqlnqaEeklrk 176
                   k+ ++++++++ l+ e +  +ek++  e++l + +++ ++ ++ +++++++ ++    +               + +DE +++L+ +l ++E+k+r+
  EFC38259.1 267 CKKRETDHNSQINILTVENSSFKEKISFLEQKLLKYKRNAKQQSQTIEKLQQKQKDPLSFNAwvqteesfpsfehlKTRDEtITSLNSELDSLEDKNRQ 365
                 567777777777777777777777777777777777777777777777777777776666666667777777777789999345799999999999999 PP

       ATG16 177 le 178
                 l+
  EFC38259.1 366 LR 367
                 87 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.027
       ATG16 111 lqkleeklkedeerlaeleaeraaletklkdreeelrekeklvq.......dlqDElsaLqlqlnqaEeklrkle 178
                 l++++e++++ +++l++le+++++l+ +l+  + + +   + ++       +l+  ls ++    + E++ r le
  EFC38259.1 342 LKTRDETITSLNSELDSLEDKNRQLRAQLEYYASHAHNHSEYNEellrenqNLKNILSEMNRGRAKDEQRVRMLE 416
                 555555555555555555555555555555555555555555550000000555555555555555555555555 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.0022
       ATG16  72 qsakiqsleqklaqlreelaelyksrgelaqrllelneelqkleeklkedeerlaeleae 131
                  s++ ++l  + + l++ l+e+ + r++ +qr++ l+ el+ ++ +++++++ +++++++
  EFC38259.1 380 HSEYNEELLRENQNLKNILSEMNRGRAKDEQRVRMLERELEIRDVEIEKRNKFIRKMNES 439
                 567777788888889999999999999999999999999999999999999999988765 PP

>> MAD  Mitotic checkpoint protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5  68.3   0.00078       4.6      17     352 ..      81     423 ..      66     439 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.00078
         MAD  17 elkqkelehkrarielekkasalkrqleeesdrnqelqkrikllekreeekeealreqiElarlkkknlealnkkekekesklaearevisalknelae 115
                 e k +e+e++r ++ le    +l+ + +  +++  e ++ +k  e++ e+ +++  eq  +  +++k+l  ++kkek +++k+++ + + ++  +e+  
  EFC38259.1  81 ETKVQEMESERRKLSLECD--TLRSENKWYRKKLTETEHSLKTTEEKFETIKKSFDEQQVILSSLEKTLCDTKKKEKKRQQKQEQKKLLLQQTSDEVIT 177
                 4555666666666666665..999999999****************************99*************************************** PP

         MAD 116 lkrqiekqelelsekeseleelqerldllkkk.lse.leqliqqlekkqkelaeaeqrikeLefeiqsqeddslivknskselaripelekelerlree 212
                 l++++e++e   ++ e e e lq++l + + k l + l q  ++l ++  e   a++r+k+Le e ++ e++  ++k   +   +  +le  ++r   +
  EFC38259.1 178 LREKLERKETRAKALEIEAEYLQKQLGEIRDKnLDDkLRQYESDLYNERLEKDMAQDRVKTLEKEKEKVEHELFELKIRVE--KSYGDLEFCKKRETDH 274
                 *************************9776655044313333366777777888899**********999999888876444..6899************ PP

         MAD 213 nkklnelkenkelLkEevedlkkkLereEk.areelvkLelekekle..qeLksWeklaqdtgL..nlrsP....ealsrkieqLqqeeivlkeekssl 302
                 n+++n l  +++  kE++  l++kL ++ + a+++  ++e  ++k +     ++W++++ +      l++       l +++  L +++ +l ++    
  EFC38259.1 275 NSQINILTVENSSFKEKISFLEQKLLKYKRnAKQQSQTIEKLQQKQKdpLSFNAWVQTEESFPSfeHLKTRdetiTSLNSELDSLEDKNRQLRAQLEYY 373
                 *************************8886425556666654444444004579*****9986545655543111157999******************* PP

         MAD 303 esslkqlekaqreleqelaqllkkiedlkkkrkehkelkrRLQrrvlllt 352
                 +s++++  + ++el +e ++l++ + +++ +r + ++ +r L r + +  
  EFC38259.1 374 ASHAHNHSEYNEELLRENQNLKNILSEMNRGRAKDEQRVRMLERELEIRD 423
                 ********************988888899999888888888888776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (449 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3338  (0.186179); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                       123  (0.00686039); expected 17.9 (0.001)
Passed Fwd filter:                        57  (0.00317921); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.39u 0.45s 00:00:01.84 Elapsed: 00:00:00.59
# Mc/sec: 2297.85
//
Query:       EFC38260.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-22   79.5   0.6    4.5e-22   78.2   0.6    1.7  1  Linker_histone  linker histone H1 and H5 family
    0.00082   18.4   5.5    0.00087   18.4   5.5    1.1  1  Radial_spoke    Radial spokehead-like protein
  ------ inclusion threshold ------
      0.024   14.8   7.6      0.037   14.2   7.6    1.3  1  CPSF100_C       Cleavage and polyadenylation factor 2 C-termi
      0.034   14.2   0.1      0.084   13.0   0.1    1.7  1  MerR_1          MerR HTH family regulatory protein
      0.075   12.2   6.0        0.1   11.8   6.0    1.2  1  MMU163          Mitochondrial protein up-regulated during mei
        0.2   11.3   5.2        0.3   10.8   5.2    1.4  1  FAM176          FAM176 family
       0.21    9.8  14.0       0.24    9.7  14.0    1.1  1  CDC45           CDC45-like protein
       0.25   11.8   3.2       0.42   11.1   3.2    1.3  1  GOLD_2          Golgi-dynamics membrane-trafficking
       0.31   10.0   5.7       0.37    9.7   5.7    1.2  1  DUF913          Domain of Unknown Function (DUF913)
       0.47   10.9   7.1       0.65   10.4   7.1    1.4  1  RNA_pol_Rpc4    RNA polymerase III RPC4
        1.2    9.2   6.0        1.3    9.1   6.0    1.2  1  DDHD            DDHD domain
        2.2    8.0   9.9        2.5    7.8   9.9    1.2  1  AAA_11          AAA domain
          3    6.6  10.3        3.4    6.4  10.3    1.1  1  ALMT            Aluminium activated malate transporter
        3.7    6.2   7.4        4.1    6.1   7.4    1.1  1  Presenilin      Presenilin


Domain annotation for each model (and alignments):
>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.2   0.6   3.5e-25   4.5e-22       1      72 [.      17      81 ..      17      83 .. 0.94

  Alignments for each domain:
  == domain 1  score: 78.2 bits;  conditional E-value: 3.5e-25
  Linker_histone  1 hpsykdMikeAIkalkerkGsSrqaIkkyikakykvvdvskfksllkkalkkgvekgelvqpkgkGasGsfK 72
                    hp+y dM++eAI++l +r+G+S++aIkky+++ky++  ++  +++lk a+kk+ve+++lv++k     Gs+K
      EFC38260.1 17 HPKYTDMVLEAIIQLRKRNGASLPAIKKYMEEKYEL--PETYNTHLKLAIKKLVESEKLVKVK-----GSYK 81
                    9**********************************8..78889*******************9.....6666 PP

>> Radial_spoke  Radial spokehead-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   5.5   6.8e-07   0.00087     122     211 ..      52     143 ..       6     160 .. 0.73

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 6.8e-07
  Radial_spoke 122 LsreeifrlalalkkLveekplekvrFwGkilGtkanYyiveaelkegeeeeeeeeeeeeeeeeeeeeeeeeeeeee..elPkskykpppei 211
                   L+++  ++l la+kkLve+++l kv+   k+    +  y  e ++  +++e+++e+e+e++++++++++++ee++e+  ++ k+k++  p+ 
    EFC38260.1  52 LPETYNTHLKLAIKKLVESEKLVKVKGSYKVEADYKKSYMKENKIVLEKKESDDEDEKEDKKDKKSKKSKKEESDESskKKKKIKRRSLPRR 143
                   77788899******************999*99988888999999887777776666655544444444444444333223333333332222 PP

>> CPSF100_C  Cleavage and polyadenylation factor 2 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   7.6   2.9e-05     0.037      16      89 ..      68     142 ..      58     159 .. 0.47

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.9e-05
   CPSF100_C  16 veglevatvtgeleieeeaeeaeeeekeeeeeeeeeeeeeeeaskkqklaeksekeaseeeseekkes.lptldv 89 
                 ve+ ++++v+g+ ++e++ +++  +e++   e++e+++e+e+++kk k+++ks+ke+s+e+s++kk+   + l  
  EFC38260.1  68 VESEKLVKVKGSYKVEADYKKSYMKENKIVLEKKESDDEDEKEDKKDKKSKKSKKEESDESSKKKKKIkRRSLPR 142
                 566889999999998877433333333333333333333333333333322223333332222222220223333 PP

>> MerR_1  MerR HTH family regulatory protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   6.6e-05     0.084      45      68 ..      24      48 ..      22      49 .. 0.94

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 6.6e-05
                HHHHHHHHHH.TT--GGG---XXXX CS
      MerR_1 45 rLklikyLlk.rGltlkgikkllns 68
                +L+ i +L+k +G +l++ikk++++
  EFC38260.1 24 VLEAIIQLRKrNGASLPAIKKYMEE 48
                699********************97 PP

>> MMU163  Mitochondrial protein up-regulated during meiosis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   6.0   7.9e-05       0.1      94     164 ..      67     137 ..      52     158 .. 0.62

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 7.9e-05
      MMU163  94 eilserivragtvleeeekeeedlgdeklvvrWktegkeskkkeeggkaekekveksasskssksekskke 164
                  + se++v+    ++ e++ ++++++e  +v  k e++++++ke++++++++k++k++s++ssk++k+ k+
  EFC38260.1  67 LVESEKLVKVKGSYKVEADYKKSYMKENKIVLEKKESDDEDEKEDKKDKKSKKSKKEESDESSKKKKKIKR 137
                 45699***999999999996677777777776677765555555444444444444444444444443333 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   5.2   0.00023       0.3      52      97 ..      87     130 ..      67     166 .. 0.54

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00023
      FAM176  52 erlkkkkkklkeesekasededeeeeeeeedsseseaeeelsefer 97 
                 +++  k++k     ek+++d+++e+e++++++s+++ +ee +e+++
  EFC38260.1  87 KKSYMKENKIV--LEKKESDDEDEKEDKKDKKSKKSKKEESDESSK 130
                 22222222222..223334444444444444444443444322222 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  14.0   0.00019      0.24     124     191 ..      86     154 ..      55     169 .] 0.36

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00019
       CDC45 124 ealeeeeesdeede...eeeeeddddeeeeeeeeedeedeeedeeeskkkrk..sksdeeeesddddersrkr 191
                 ++ ++++e+    +   e++e+dd+de+e++++++++++++e+++es+kk+k  ++++  ++ ++++ r+ kr
  EFC38260.1  86 YKKSYMKEN----KivlEKKESDDEDEKEDKKDKKSKKSKKEESDESSKKKKkiKRRSLPRRPKRKSPRRMKR 154
                 222222222....133322222222222222222222222222222222222011111111111222222222 PP

>> GOLD_2  Golgi-dynamics membrane-trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   3.2   0.00033      0.42      41      84 ..      90     133 ..      78     152 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00033
      GOLD_2  41 eatskavsvkvsesddeedeeeeeeeekveeedvekgsvkaakp 84 
                  ++ +++ ++  esdde+++e+++++++ ++++ e  + +++k 
  EFC38260.1  90 YMKENKIVLEKKESDDEDEKEDKKDKKSKKSKKEESDESSKKKK 133
                 456788999999**999998888885544444444443333332 PP

>> DUF913  Domain of Unknown Function (DUF913)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   5.7   0.00029      0.37     241     321 ..      41     133 ..      15     146 .. 0.50

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00029
      DUF913 241 avikmlarvvelgkeka..akllved........assasskseasssssssetkeeek......ssededvemedaeeetesesdeseeseeekekn 321
                 a+ k +++  el ++++   kl +++        + + s k ea+ ++s ++++   k      +s+ded e+ed++++++++s+++e++e++k+k+
  EFC38260.1  41 AIKKYMEEKYELPETYNthLKLAIKKlveseklvKVKGSYKVEADYKKSYMKEN---KivlekkESDDED-EKEDKKDKKSKKSKKEESDESSKKKK 133
                 455555555555555556633333334444455533333333333333333333...1455543333333.44444333333333333333334433 PP

>> RNA_pol_Rpc4  RNA polymerase III RPC4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   7.1   0.00051      0.65      25      65 ..     100     140 ..      37     160 .. 0.53

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00051
  RNA_pol_Rpc4  25 eddkseaesqsaekakaeeeskaekasgaeaeekkskkkss 65 
                   +++++++++++++k+k++++sk+e+++++++++kk k+ s 
    EFC38260.1 100 KKESDDEDEKEDKKDKKSKKSKKEESDESSKKKKKIKRRSL 140
                   22222222222222222222222222222222222222222 PP

>> DDHD  DDHD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   6.0     0.001       1.3      77     166 ..      39     134 ..       8     164 .. 0.44

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.001
        DDHD  77 iprykrrkllhlelkesltsigaalkqkvsglvssls................allnrslelaeeesaslaessksherasesskasqeskaaesstas 159
                 +p +k++   + el e++++  +   +k   lv+s +                +         +e++  l+++++++e+++e++k+++++k++++++ +
  EFC38260.1  39 LPAIKKYMEEKYELPETYNTHLKLAIKK---LVESEKlvkvkgsykveadykkS-------YMKENKIVLEKKESDDEDEKEDKKDKKSKKSKKEESDE 127
                 5555555444444444443333333332...33333333233333333222211.......11222222222222222222222222222222222222 PP

        DDHD 160 ssakssk 166
                 ss+k++k
  EFC38260.1 128 SSKKKKK 134
                 2222111 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   9.9     0.002       2.5     100     176 ..      69     137 ..      19     162 .. 0.47

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.002
      AAA_11 100 iseavksvsleekvekrlekeekaqlakeiskeleklakelrafeeeeekeklkkskekskskleqerrklkkerke 176
                  se++ +v+ ++kve+ ++k+   ++ ++i  e+++ ++e ++++++      +k+++ksk++++ e++k kk++k+
  EFC38260.1  69 ESEKLVKVKGSYKVEADYKKS--YMKENKIVLEKKESDDEDEKEDKK------DKKSKKSKKEESDESSKKKKKIKR 137
                 345555666666666666553..222222222222222222222222......222222222222222222222211 PP

>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4  10.3    0.0027       3.4     310     422 ..      39     154 ..       7     166 .. 0.55

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0027
        ALMT 310 lrelaesvkkmkklskveellkevkvaaeeLqsk..l.dskskLlvnsekweaakkkeka..eeveekkeeekeseskkeeaeaveeaeseseksllke 403
                 l  +++ ++++ +l   e    ++k a+++L ++  l ++k    v+++ ++   k++k+  e++e+  e eke++++k+++++++e++ es+k+++k 
  EFC38260.1  39 LPAIKKYMEEKYELP--ETYNTHLKLAIKKLVESekLvKVKGSYKVEADYKKSYMKENKIvlEKKESDDEDEKEDKKDKKSKKSKKEESDESSKKKKKI 135
                 444444444433333..4567788888888854311337777777777765544444443112222333333333333333455555555666666666 PP

        ALMT 404 skrslklskkesapaeesl 422
                 ++rsl +++k+++p ++++
  EFC38260.1 136 KRRSLPRRPKRKSPRRMKR 154
                 6677777777777776643 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   7.4    0.0032       4.1     230     287 ..      98     136 ..      42     165 .. 0.43

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0032
  Presenilin 230 aevaeseeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessae 287
                  e++es++e+e+e+kk+++s++sk+ees+e                   ss+++++ +
  EFC38260.1  98 LEKKESDDEDEKEDKKDKKSKKSKKEESDE-------------------SSKKKKKIK 136
                 111111111111111111111111111111...................111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2891  (0.161247); expected 358.6 (0.02)
Passed bias filter:                      677  (0.0377601); expected 358.6 (0.02)
Passed Vit filter:                       168  (0.00937029); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.61u 0.35s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 1007.80
//
Query:       EFC38261.1  [L=571]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.7e-19   68.0   2.6    1.6e-07   31.5   0.1    4.5  5  TPR_12        Tetratricopeptide repeat
    4.5e-17   60.8   9.9    0.00037   20.5   0.0    6.2  5  TPR_8         Tetratricopeptide repeat
    1.3e-15   56.2   4.5     0.0088   16.0   0.1    6.5  6  TPR_7         Tetratricopeptide repeat
    3.2e-14   52.1   5.2     0.0039   17.0   0.0    5.8  6  TPR_1         Tetratricopeptide repeat
    4.7e-13   48.2   4.4       0.04   14.0   0.0    6.2  6  TPR_2         Tetratricopeptide repeat
    1.5e-06   28.4   3.9       0.29   11.9   0.0    5.0  4  TPR_6         Tetratricopeptide repeat
    9.8e-06   25.3   0.0       0.11   12.4   0.0    4.3  5  TPR_10        Tetratricopeptide repeat
    2.9e-05   24.5   0.0         11    7.2   0.0    4.6  4  TPR_14        Tetratricopeptide repeat
    0.00027   20.4   0.2       0.63    9.4   0.0    2.3  2  TPR_MalT      MalT-like TPR region
     0.0019   17.9   0.4        5.8    6.7   0.1    3.7  3  TPR_11        TPR repeat
      0.002   18.4   0.0        3.1    8.4   0.0    3.5  3  TPR_17        Tetratricopeptide repeat
     0.0064   16.7   5.0        1.3    9.2   0.5    3.8  3  ANAPC3        Anaphase-promoting complex, cyclosome, subunit 
  ------ inclusion threshold ------
      0.021   15.3   0.4        1.3    9.6   0.1    3.6  4  TPR_19        Tetratricopeptide repeat
      0.026   14.2  10.4       0.16   11.7   0.1    4.1  4  RPN7          26S proteasome subunit RPN7
      0.065   13.4   0.0       0.37   11.0   0.0    2.3  2  TPR_9         Tetratricopeptide repeat
      0.074   13.3   2.0         26    5.3   0.0    4.6  4  PPR           PPR repeat
      0.079   12.7   0.9        1.6    8.5   0.1    2.7  3  DSBA          DSBA-like thioredoxin domain
        0.1   13.3   0.0        8.1    7.2   0.0    3.0  2  TPR_16        Tetratricopeptide repeat
       0.15   11.6   1.5        6.9    6.2   0.1    3.0  3  Peripla_BP_2  Periplasmic binding protein


Domain annotation for each model (and alignments):
>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       1.8   1.7e+03      10      48 ..     285     320 ..     280     337 .. 0.68
   2 ?    6.1   0.1     0.015        14       8      40 ..     343     373 ..     335     384 .. 0.81
   3 !   26.1   0.0   8.4e-09   7.9e-06       6      76 ..     388     456 ..     384     457 .. 0.92
   4 !   31.5   0.1   1.6e-10   1.6e-07       8      77 .]     470     537 ..     463     537 .. 0.94
   5 !   18.6   0.0   1.8e-06    0.0017       3      47 ..     507     547 ..     505     555 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.8
      TPR_12  10 aavlrrlgrydeAlellekaleiarrllGpdhpltattl 48 
                 a+ + r+g++++  +++++  + +++    d+ +t  + 
  EFC38261.1 285 AESYKRRGKFEKVYDIFKQIADYFESE--RDY-NTMYYF 320
                 777788888888888887777777655..333.555555 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.015
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpd 40 
                 n + ++ r+g+   A +++e+ + +a ++  +d
  EFC38261.1 343 NAGKMYERMGKVNMAVKYHEAHMSLAHSA--GD 373
                 78999999***********9999999877..44 PP

  == domain 3  score: 26.1 bits;  conditional E-value: 8.4e-09
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaiae 76 
                 + ++++    + +++ A+ ++ek+l  a+ l  +d++  +++l+ Lg +y  l ++e+A+e+ +  + ++e
  EFC38261.1 388 YMKMGEDSENQSDLHNACLFYEKSLKNAKML--KDKEMISNSLFKLGNVYKSLQDFEKAIEYQQMYTTVCE 456
                 556788888899*******************..******************************99988887 PP

  == domain 4  score: 31.5 bits;  conditional E-value: 1.6e-10
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaiaek 77 
                  l++++ +  + d+A+e +++ l  a++++++d+    t+ + Lg+++   g+++e ++++e++ ++a+k
  EFC38261.1 470 ALGELYEQTNEIDKAIETYNQFLSSAEEAQDDDR--IGTACIKLGMALGSKGQHDESIAFFERSFELAKK 537
                 69***************************88888..999****************************986 PP

  == domain 5  score: 18.6 bits;  conditional E-value: 1.8e-06
      TPR_12   3 atalnnlaavlrrlgrydeAlellekaleiarrllGpdhpltatt 47 
                 a++   l+++l   g++de+++++e++ e+a+++  +d++   ++
  EFC38261.1 507 ACIK--LGMALGSKGQHDESIAFFERSFELAKKT--KDNAKIGEA 547
                 5555..9**************************9..776655554 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.1      0.11     1e+02       6      23 ..     343     360 ..     340     368 .. 0.91
   2 ?    2.5   0.1      0.23   2.2e+02      11      29 ..     395     413 ..     386     416 .. 0.76
   3 !   17.6   0.0   3.3e-06    0.0031       3      24 ..     427     448 ..     425     456 .. 0.92
   4 !   17.9   0.1   2.6e-06    0.0024       2      31 ..     466     495 ..     465     497 .. 0.90
   5 !   20.5   0.0   3.9e-07   0.00037       3      33 ..     507     537 ..     505     538 .. 0.94

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.11
                 HHHHHHHHTT-HHHHHHH CS
       TPR_8   6 nlgsiylklgdyeeAkey 23 
                 n g+ y+ +g+ ++A++y
  EFC38261.1 343 NAGKMYERMGKVNMAVKY 360
                 7899************99 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.23
                 HHHTT-HHHHHHHHHHHHH CS
       TPR_8  11 ylklgdyeeAkeyyekale 29 
                  +++ d+++A  +yek l+
  EFC38261.1 395 SENQSDLHNACLFYEKSLK 413
                 5678899*********998 PP

  == domain 3  score: 17.6 bits;  conditional E-value: 3.3e-06
                 HHHHHHHHHHHTT-HHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyy 24 
                 ++++lg++y++l+d+e+A+ey 
  EFC38261.1 427 SLFKLGNVYKSLQDFEKAIEYQ 448
                 79*******************7 PP

  == domain 4  score: 17.9 bits;  conditional E-value: 2.6e-06
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekaleld 31 
                 ++ + lg +y++++++++A+e+y++ l+ +
  EFC38261.1 466 DSFCALGELYEQTNEIDKAIETYNQFLSSA 495
                 67899********************99876 PP

  == domain 5  score: 20.5 bits;  conditional E-value: 3.9e-07
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 a+ +lg+++ ++g+++e+++++e+  el+++
  EFC38261.1 507 ACIKLGMALGSKGQHDESIAFFERSFELAKK 537
                 899*************************987 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.1      0.29   2.7e+02       6      24 ..     285     303 ..     284     315 .. 0.87
   2 !   10.6   0.0   0.00051      0.48       4      33 ..     343     372 ..     342     375 .. 0.86
   3 ?    1.2   0.0      0.52   4.9e+02      10      26 ..     396     412 ..     383     420 .. 0.85
   4 !   14.3   0.0   3.2e-05      0.03       1      21 [.     427     447 ..     427     460 .. 0.94
   5 !   16.0   0.1   9.3e-06    0.0088       1      30 [.     467     497 ..     467     503 .. 0.80
   6 !    6.9   0.0    0.0074         7       2      30 ..     508     536 ..     507     542 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.29
       TPR_7   6 arlysrlGdyeeAielyeq 24 
                 a+ y r+G++e+  ++++q
  EFC38261.1 285 AESYKRRGKFEKVYDIFKQ 303
                 67899********999999 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00051
       TPR_7   4 nLarlysrlGdyeeAielyeqsLaltkdpe 33 
                 n + +y+r+G+   A++++e+++ l+ + +
  EFC38261.1 343 NAGKMYERMGKVNMAVKYHEAHMSLAHSAG 372
                 6799*****************988877655 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.52
       TPR_7  10 srlGdyeeAielyeqsL 26 
                 +++ d  +A  +ye+sL
  EFC38261.1 396 ENQSDLHNACLFYEKSL 412
                 5799999********87 PP

  == domain 4  score: 14.3 bits;  conditional E-value: 3.2e-05
       TPR_7   1 aLlnLarlysrlGdyeeAiel 21 
                 +L+ L+++y +l+d+e+Aie+
  EFC38261.1 427 SLFKLGNVYKSLQDFEKAIEY 447
                 6889****************8 PP

  == domain 5  score: 16.0 bits;  conditional E-value: 9.3e-06
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsL.altk 30 
                 ++++L++ly++ ++ ++Aie y q L   ++
  EFC38261.1 467 SFCALGELYEQTNEIDKAIETYNQFLsSAEE 497
                 579*******************998844433 PP

  == domain 6  score: 6.9 bits;  conditional E-value: 0.0074
       TPR_7   2 LlnLarlysrlGdyeeAielyeqsLaltk 30 
                 +  L+ +  + G+++e i ++e+s +l+k
  EFC38261.1 508 CIKLGMALGSKGQHDESIAFFERSFELAK 536
                 6679999999*************766665 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.56   5.3e+02       7      24 ..     284     301 ..     282     304 .. 0.79
   2 ?    3.8   0.0     0.059        56       8      25 ..     345     362 ..     343     370 .. 0.87
   3 ?   -2.7   0.0       6.7   6.4e+03      11      16 ..     388     393 ..     386     413 .. 0.51
   4 !   17.0   0.0   4.1e-06    0.0039       3      23 ..     427     447 ..     425     447 .. 0.90
   5 !   13.6   0.0   4.8e-05     0.046       2      26 ..     466     490 ..     465     492 .. 0.93
   6 !   13.6   0.0   4.8e-05     0.045       3      31 ..     507     535 ..     506     537 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.56
                 HHHHHHHTT-HHHHHHHH CS
       TPR_1   7 lGnayfklgkydeAleyy 24 
                 ++  y + gk+++  + +
  EFC38261.1 284 KAESYKRRGKFEKVYDIF 301
                 57899999***9976655 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.059
                 HHHHHHTT-HHHHHHHHH CS
       TPR_1   8 GnayfklgkydeAleyye 25 
                 G +y ++gk + A++y e
  EFC38261.1 345 GKMYERMGKVNMAVKYHE 362
                 899************976 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 6.7
                 HHHTT- CS
       TPR_1  11 yfklgk 16 
                 y+k+g+
  EFC38261.1 388 YMKMGE 393
                 555553 PP

  == domain 4  score: 17.0 bits;  conditional E-value: 4.1e-06
                 HHHHHHHHHHHTT-HHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAley 23 
                 +l+ lGn+y +l+++++A+ey
  EFC38261.1 427 SLFKLGNVYKSLQDFEKAIEY 447
                 6889***************98 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 4.8e-05
                 HHHHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyek 26 
                 ++++ lG +y + ++ d+A+e y++
  EFC38261.1 466 DSFCALGELYEQTNEIDKAIETYNQ 490
                 67899******************96 PP

  == domain 6  score: 13.6 bits;  conditional E-value: 4.8e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALeln 31 
                 a+  lG+a+ ++g++de ++++e+  el 
  EFC38261.1 507 ACIKLGMALGSKGQHDESIAFFERSFELA 535
                 6678********************99986 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0       1.1   9.9e+02       8      26 ..     285     303 ..     281     310 .. 0.80
   2 ?    1.0   0.0      0.65   6.1e+02       6      23 ..     343     360 ..     341     360 .. 0.90
   3 ?    2.7   0.0      0.18   1.7e+02       2      29 ..     386     413 ..     385     416 .. 0.89
   4 !   14.0   0.0   4.2e-05      0.04       3      23 ..     427     447 ..     424     449 .. 0.79
   5 !   11.8   0.0   0.00021       0.2       4      29 ..     468     493 ..     465     498 .. 0.88
   6 !   12.9   0.0   9.6e-05     0.091       3      32 ..     507     536 ..     505     538 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 1.1
       TPR_2   8 GlayyklgdyeeAleafek 26 
                 +++y ++g++e+  + f++
  EFC38261.1 285 AESYKRRGKFEKVYDIFKQ 303
                 889*******997666666 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.65
       TPR_2   6 nlGlayyklgdyeeAlea 23 
                 n G+ y+++g+ + A+++
  EFC38261.1 343 NAGKMYERMGKVNMAVKY 360
                 6799**********9987 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.18
       TPR_2   2 ealynlGlayyklgdyeeAleafekAle 29 
                 ++++ +G+  +++ d+  A  ++ek+l+
  EFC38261.1 386 RVYMKMGEDSENQSDLHNACLFYEKSLK 413
                 6789999999****************98 PP

  == domain 4  score: 14.0 bits;  conditional E-value: 4.2e-05
       TPR_2   3 alynlGlayyklgdyeeAlea 23 
                  l+ lG++y  l+d+e+A+e+
  EFC38261.1 427 SLFKLGNVYKSLQDFEKAIEY 447
                 578888888888888888887 PP

  == domain 5  score: 11.8 bits;  conditional E-value: 0.00021
       TPR_2   4 lynlGlayyklgdyeeAleafekAle 29 
                  ++lG++y++ ++ ++A+e +++ l+
  EFC38261.1 468 FCALGELYEQTNEIDKAIETYNQFLS 493
                 679*******************9876 PP

  == domain 6  score: 12.9 bits;  conditional E-value: 9.6e-05
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldP 32 
                 a+  lG+a+  +g+++e +++fe++ el+ 
  EFC38261.1 507 ACIKLGMALGSKGQHDESIAFFERSFELAK 536
                 7899**********************9986 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1         2   1.9e+03       7      29 ..     285     307 ..     281     308 .. 0.83
   2 !    9.0   0.0    0.0025       2.4       2      22 ..     427     447 ..     426     453 .. 0.91
   3 !   11.9   0.0   0.00031      0.29       6      28 ..     471     493 ..     470     495 .. 0.92
   4 ?    3.7   0.0      0.12   1.1e+02       5      25 ..     510     530 ..     507     531 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 2
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   7 alsyrklgdtdkAlealerlike 29 
                 a+sy++ g+ +k  ++++++ + 
  EFC38261.1 285 AESYKRRGKFEKVYDIFKQIADY 307
                 89****88*99999999988775 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0025
                 HHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlea 22 
                 +l+kl+  y++l+d +kA+e+
  EFC38261.1 427 SLFKLGNVYKSLQDFEKAIEY 447
                 69*********77******97 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 0.00031
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAlealerlik 28 
                 l+++y+++++ dkA+e+++++++
  EFC38261.1 471 LGELYEQTNEIDKAIETYNQFLS 493
                 79*****99************97 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.12
                 HHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealer 25 
                 kl++++ + g++d++++ +er
  EFC38261.1 510 KLGMALGSKGQHDESIAFFER 530
                 79*****988*********97 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.36   3.4e+02       7      26 ..     343     362 ..     340     364 .. 0.88
   2 ?   -2.8   0.0       7.1   6.7e+03      11      36 ..     387     412 ..     386     414 .. 0.71
   3 ?    5.2   0.0     0.021        20       8      25 ..     431     448 ..     424     453 .. 0.76
   4 ?   -2.2   0.0       4.4   4.2e+03       8      22 ..     471     485 ..     469     490 .. 0.74
   5 !   12.4   0.0   0.00011      0.11       4      35 ..     507     538 ..     505     541 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.36
      TPR_10   7 NLanalrqrgrydeAealle 26 
                 N + ++ ++g+ + A++++e
  EFC38261.1 343 NAGKMYERMGKVNMAVKYHE 362
                 77899*************77 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 7.1
      TPR_10  11 alrqrgrydeAealleealairrrll 36 
                 ++ ++g+  e   +l+ a   +++ l
  EFC38261.1 387 VYMKMGEDSENQSDLHNACLFYEKSL 412
                 67888888887777777777777765 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.021
      TPR_10   8 LanalrqrgrydeAeall 25 
                 L+n++ +++++++A +++
  EFC38261.1 431 LGNVYKSLQDFEKAIEYQ 448
                 788888888888888775 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 4.4
      TPR_10   8 LanalrqrgrydeAe 22 
                 L+ ++ q+++ d+A 
  EFC38261.1 471 LGELYEQTNEIDKAI 485
                 777888888877775 PP

  == domain 5  score: 12.4 bits;  conditional E-value: 0.00011
      TPR_10   4 slnNLanalrqrgrydeAealleealairrrl 35 
                 ++  L++al + g++de+ a++e++ ++ +++
  EFC38261.1 507 ACIKLGMALGSKGQHDESIAFFERSFELAKKT 538
                 5667***********************99986 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.78   7.4e+02       8      36 ..     285     313 ..     280     319 .. 0.78
   2 ?    4.2   0.0     0.099        94       4      23 ..     428     447 ..     425     451 .. 0.90
   3 ?    7.2   0.0     0.012        11       6      31 ..     470     495 ..     467     504 .. 0.84
   4 ?    5.0   0.0     0.055        52       7      32 ..     511     536 ..     507     553 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.78
      TPR_14   8 aeallalGdpdeAiallrralalaPddae 36 
                 ae + ++G++++  ++++++ + + ++++
  EFC38261.1 285 AESYKRRGKFEKVYDIFKQIADYFESERD 313
                 7889***********99998766665555 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.099
      TPR_14   4 llalaeallalGdpdeAial 23 
                 l +l+ ++  l+d+++Ai++
  EFC38261.1 428 LFKLGNVYKSLQDFEKAIEY 447
                 6789*************986 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.012
      TPR_14   6 alaeallalGdpdeAiallrralala 31 
                 al+e++++  + d+Ai+ +++ l+ a
  EFC38261.1 470 ALGELYEQTNEIDKAIETYNQFLSSA 495
                 79******************988844 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.055
      TPR_14   7 laeallalGdpdeAiallrralalaP 32 
                 l+ al   G++de+ia ++r  +la 
  EFC38261.1 511 LGMALGSKGQHDESIAFFERSFELAK 536
                 56666678************988765 PP

>> TPR_MalT  MalT-like TPR region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.1    0.0019       1.8      58     147 ..     356     450 ..     328     463 .. 0.59
   2 !    9.4   0.0   0.00066      0.63      45     114 ..     470     539 ..     465     547 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0019
    TPR_MalT  58 aAlqalqeaeklarqadslhv......allall.qqaeilvaqGrLheAletyeqalqlateqglqqlplvgfllvlladllyEwndLeeAeqhlqe 147
                  A++ ++++ +la +a+   +       l+ ++ + +e    q +Lh+A   ye++l+ a++ + ++  +    l +l++++    d+e+A ++ q 
  EFC38261.1 356 MAVKYHEAHMSLAHSAGDQVQeerainQLWRVYmKMGEDSENQSDLHNACLFYEKSLKNAKMLKDKE--MISNSLFKLGNVYKSLQDFEKAIEYQQM 450
                 4444444433333222222110110112333323566666777788888888888888777777664..5555556778888888888888776654 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00066
    TPR_MalT  45 vlGeasllqGdleaAlqalqeaeklarqadslhvallallqqaeilvaqGrLheAletyeqalqlateqg 114
                 +lGe +  +++ ++A +++++  + a +a+  ++  +a +++++ l  +G+ +e++  +e++++la++++
  EFC38261.1 470 ALGELYEQTNEIDKAIETYNQFLSSAEEAQDDDRIGTACIKLGMALGSKGQHDESIAFFERSFELAKKTK 539
                 689999999999**************99999999999999***********************9999876 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.0    0.0067       6.3       5      23 ..     429     447 ..     426     453 .. 0.59
   2 !    6.7   0.1    0.0062       5.8       1      19 [.     472     490 ..     468     492 .. 0.91
   3 ?   -0.9   0.0       1.5   1.4e+03       6      15 ..     517     526 ..     512     534 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0067
      TPR_11   5 yeqGkyeeAieaYkkAlkl 23 
                 +++G+  +++++++kA+++
  EFC38261.1 429 FKLGNVYKSLQDFEKAIEY 447
                 5555566666666666655 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0062
      TPR_11   1 GdayyeqGkyeeAieaYkk 19 
                 G +y + +++++Aie Y++
  EFC38261.1 472 GELYEQTNEIDKAIETYNQ 490
                 6678899**********98 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 1.5
      TPR_11   6 eqGkyeeAie 15 
                 ++G+ +e+i+
  EFC38261.1 517 SKGQHDESIA 526
                 89******98 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0    0.0033       3.1      13      34 .]     425     446 ..     407     446 .. 0.78
   2 ?    5.8   0.0     0.023        21      10      34 .]     462     486 ..     458     486 .. 0.86
   3 ?   -1.9   0.0       6.3   5.9e+03      18      33 ..     510     525 ..     509     526 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0033
      TPR_17  13 adaynnLAelllknGdlmtArq 34 
                 +++++ L+++++++ d+++A++
  EFC38261.1 425 SNSLFKLGNVYKSLQDFEKAIE 446
                 89******************86 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.023
      TPR_17  10 PnnadaynnLAelllknGdlmtArq 34 
                 +  +d+++ L+el+++ ++ ++A++
  EFC38261.1 462 KGKSDSFCALGELYEQTNEIDKAIE 486
                 5579****************99986 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 6.3
      TPR_17  18 nLAelllknGdlmtAr 33 
                  L+ +l ++G++++ +
  EFC38261.1 510 KLGMALGSKGQHDESI 525
                 5899999****99865 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0     0.023        22      26      49 ..     281     304 ..     270     320 .. 0.84
   2 !    9.2   0.5    0.0014       1.3       1      44 [.     397     446 ..     397     458 .. 0.64
   3 ?    1.5   0.0      0.38   3.6e+02      20      51 ..     462     493 ..     450     529 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.023
                 HHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  26 ayllAlclylngqykrAyellrka 49 
                  + +A+++ ++g++++ y+++++ 
  EFC38261.1 281 MLVKAESYKRRGKFEKVYDIFKQI 304
                 4568*****************997 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0014
                 HTT-HHHHHHHHHHHH.HHH--HHH.......HHHHHHHHHHTT-HHHHHH CS
      ANAPC3   1 dqnnyknAiflaerllaaetesped.......ayllAlclylngqykrAye 44 
                 +q +++nA +++e+ l +++++++d       ++ l+ ++ +++++++A+e
  EFC38261.1 397 NQSDLHNACLFYEKSL-KNAKMLKDkemisnsLFKLGNVYKSLQDFEKAIE 446
                 578999**********.5555555511111115555666666666666655 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.38
                 H--HHHHHHHHHHHHHTT-HHHHHHHHHCTSH CS
      ANAPC3  20 tespedayllAlclylngqykrAyellrkakl 51 
                 +  +++  +l++ + ++++ ++A+e ++++ +
  EFC38261.1 462 KGKSDSFCALGELYEQTNEIDKAIETYNQFLS 493
                 5566777789999999999****999999833 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       6.5   6.1e+03      23      40 ..     376     393 ..     357     396 .. 0.68
   2 ?    0.0   0.0       1.3   1.2e+03      30      46 ..     430     446 ..     400     452 .. 0.84
   3 ?    9.6   0.1    0.0013       1.3      19      51 ..     459     491 ..     439     504 .. 0.76
   4 ?    0.2   0.0       1.2   1.1e+03       5      24 ..     519     539 ..     517     555 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 6.5
      TPR_19  23 knaearllLAeallalgq 40 
                 + ++a  +L ++++++g+
  EFC38261.1 376 QEERAINQLWRVYMKMGE 393
                 466777789999999998 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 1.3
      TPR_19  30 lLAeallalgqldeAea 46 
                  L +++ +l ++++A++
  EFC38261.1 430 KLGNVYKSLQDFEKAIE 446
                 57999*********987 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.0013
      TPR_19  19 qedpknaearllLAeallalgqldeAealLdal 51 
                 +++ + ++   +L e++ +++++d+A+++ ++ 
  EFC38261.1 459 EDKKGKSDSFCALGELYEQTNEIDKAIETYNQF 491
                 445566777778****************99875 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 1.2
      TPR_19   5 gdyaeAlalleqalqedpk.n 24 
                 g+++e +a++e+ ++ + k  
  EFC38261.1 519 GQHDESIAFFERSFELAKKtK 539
                 99**********998765532 PP

>> RPN7  26S proteasome subunit RPN7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       1.2   1.1e+03      38      68 ..     280     310 ..     261     319 .. 0.78
   2 ?    3.0   0.1     0.078        74      39      64 ..     341     366 ..     334     376 .. 0.83
   3 ?    3.5   0.3     0.053        50      20      59 ..     409     448 ..     394     461 .. 0.83
   4 ?   11.7   0.1   0.00017      0.16      40     128 ..     469     564 ..     456     567 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHCT-HHHHHHHHHTCCCC--S CS
        RPN7  38 akldlaehYlkigdleeAlkaysrireycts 68 
                  +l +ae Y + g++e+    +++i +y  s
  EFC38261.1 280 EMLVKAESYKRRGKFEKVYDIFKQIADYFES 310
                 3677889999999999999999999988765 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.078
                 HHHHHHHHHHCT-HHHHHHHHHTCCC CS
        RPN7  39 kldlaehYlkigdleeAlkaysrire 64 
                 k++ ++ Y ++g+++ A+k+ ++ + 
  EFC38261.1 341 KENAGKMYERMGKVNMAVKYHEAHMS 366
                 68899**************9987655 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.053
                 HHHHHHHHHTT-HHHHHHHHHHHHHHHHHCT-HHHHHHHH CS
        RPN7  20 daelkdakenlgkeeirrakldlaehYlkigdleeAlkay 59 
                 ++ lk+ak    ke i +   +l++ Y +  d+e+A+++ 
  EFC38261.1 409 EKSLKNAKMLKDKEMISNSLFKLGNVYKSLQDFEKAIEYQ 448
                 6789999999999999999999999999999999999864 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 0.00017
                 HHHHHHHHHCT-HHHHHHHHHTCCCC--SHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHCSSS---........HHHHHHHHHHHHHHHHHTT- CS
        RPN7  40 ldlaehYlkigdleeAlkaysrireyctslkhkidmllnlirvaiffndwdlvskylekakellekggd.......werknrlkvyeGlallairk 128
                  +l+e Y ++ ++++A+++y++ +     ++    +  + i+++++++ +++ ++ ++  +++ e +++        e+k rl  ++G a+++ + 
  EFC38261.1 469 CALGELYEQTNEIDKAIETYNQFLSSAEEAQDDDRIGTACIKLGMALGSKGQHDESIAFFERSFELAKKtkdnakiGEAKVRLGFAKGNASMQKHM 564
                 689*********************************************999999999888888887777666777788888898888888887665 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       6.3   5.9e+03      36      59 ..     345     368 ..     343     376 .. 0.74
   2 ?   11.0   0.0   0.00039      0.37       3      68 ..     433     504 ..     431     507 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 6.3
       TPR_9  36 GlllaqlGclsaAladLeaylala 59 
                 G +++++G ++ A++  ea ++la
  EFC38261.1 345 GKMYERMGKVNMAVKYHEAHMSLA 368
                 778999999999988766666555 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00039
       TPR_9   3 aiaireedweralavverllll......aPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaeai 68 
                 +++ + +d+e+a++++++   +      +    +     G l++q + + +A++  +++l+ a++a+d ++i
  EFC38261.1 433 NVYKSLQDFEKAIEYQQMYTTVcediedKKGKSDSFCALGELYEQTNEIDKAIETYNQFLSSAEEAQDDDRI 504
                 677788899999999999999999999888888889999*************************99998876 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0     0.028        26       9      25 ..     287     303 ..     286     306 .. 0.90
   2 ?   -0.4   0.1       1.8   1.7e+03       9      23 ..     347     361 ..     346     362 .. 0.82
   3 ?    0.5   0.0      0.97   9.2e+02       5      26 ..     470     491 ..     466     494 .. 0.76
   4 ?    1.9   0.0      0.35   3.3e+02       9      25 ..     514     530 ..     511     533 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.028
         PPR   9 gycknGkleeAlelfke 25 
                 +y + Gk+e++ ++fk+
  EFC38261.1 287 SYKRRGKFEKVYDIFKQ 303
                 699************98 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.8
         PPR   9 gycknGkleeAlelf 23 
                  y + Gk+ +A++++
  EFC38261.1 347 MYERMGKVNMAVKYH 361
                 58899***9999976 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.97
         PPR   5 slIsgycknGkleeAlelfkeM 26 
                 +l   y + +++++A+e +++ 
  EFC38261.1 470 ALGELYEQTNEIDKAIETYNQF 491
                 555678899999****999875 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.35
         PPR   9 gycknGkleeAlelfke 25 
                 +++++G+++e + +f++
  EFC38261.1 514 ALGSKGQHDESIAFFER 530
                 899************86 PP

>> DSBA  DSBA-like thioredoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.1    0.0017       1.6      88     129 ..     363     404 ..     333     424 .. 0.88
   2 ?    0.5   0.0      0.48   4.5e+02     105     136 ..     483     514 ..     470     526 .. 0.85
   3 ?    0.2   0.0      0.56   5.3e+02      94     137 ..     513     555 ..     507     565 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0017
                 HHHHHHHHHHHHHGHHHHHHHHHHHHHTSSS-TSSHHHHHHH CS
        DSBA  88 raarlllaagaeglaekvvrelfealwsegqaitddqellev 129
                   + l++ ag + + e++ ++l++ +++ g++   +++l  +
  EFC38261.1 363 AHMSLAHSAGDQVQEERAINQLWRVYMKMGEDSENQSDLHNA 404
                 4567899999999*********************99998776 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.48
                 HHHHHHHHHHTSSS-TSSHHHHHHHHHHTTS. CS
        DSBA 105 vvrelfealwsegqaitddqellevaekaGld 136
                 ++ e ++ ++s  ++ +dd+ +  ++ k+G+ 
  EFC38261.1 483 KAIETYNQFLSSAEEAQDDDRIGTACIKLGMA 514
                 5567899***********************95 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.56
                 HHHHHHHGHHHHHHHHHHHHHTSSS-TSSHHHHHHHHHHTTS.H CS
        DSBA  94 laagaeglaekvvrelfealwsegqaitddqellevaekaGlda 137
                 +a+g +g +++ + ++fe+ ++  ++ +d++++ e+  ++G+  
  EFC38261.1 513 MALGSKG-QHDESIAFFERSFELAKKTKDNAKIGEAKVRLGFAK 555
                 5666666.678888899999999999999988888888888744 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.29   2.7e+02      36      58 ..     427     449 ..     423     454 .. 0.85
   2 ?    7.2   0.0    0.0086       8.1       2      59 ..     470     530 ..     469     535 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.29
      TPR_16  36 AllllgdaalrqgrlaeAaalyr 58 
                 +l+ lg+++  ++++++A+++ +
  EFC38261.1 427 SLFKLGNVYKSLQDFEKAIEYQQ 449
                 57899999999999999998866 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0086
      TPR_16   2 alaraalragdyddAaaaleaalkrdpssPd...aaeAllllgdaalrqgrlaeAaalyra 59 
                 al+ ++ + ++ d+A++ ++++l ++ +  d      A   lg a+  +g ++e +a++++
  EFC38261.1 470 ALGELYEQTNEIDKAIETYNQFLSSAEEAQDddrIGTACIKLGMALGSKGQHDESIAFFER 530
                 7899999999999999999999999988777777777777777777777777777777776 PP

>> Peripla_BP_2  Periplasmic binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.17   1.6e+02      94     124 ..     290     324 ..     257     352 .. 0.77
   2 ?    6.2   0.1    0.0073       6.9      98     133 ..     465     500 ..     437     509 .. 0.86
   3 ?    0.9   0.0       0.3   2.8e+02     103     143 ..     510     550 ..     502     566 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.17
                   S....HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
  Peripla_BP_2  94 g....eslkeqiralgellgledeaeklvaeidsk 124
                        e++++ +++++  +++e+ +++++ +++  
    EFC38261.1 290 RrgkfEKVYDIFKQIADYFESERDYNTMYYFYELG 324
                   244449*****************999999888755 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0073
                   HHHHHHHHHHTT-HHHHHHHHHHHHHHHHHHHHTS- CS
  Peripla_BP_2  98 keqiralgellgledeaeklvaeidsklaaaksaid 133
                    +++ algel+++++e +k+++ +++ l +a++a d
    EFC38261.1 465 SDSFCALGELYEQTNEIDKAIETYNQFLSSAEEAQD 500
                   578889**********************99998865 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.3
                   HHHHHTT-HHHHHHHHHHHHHHHHHHHHTS-TT.-EEEEEE CS
  Peripla_BP_2 103 algellgledeaeklvaeidsklaaaksaidsekpkpvlvf 143
                    lg++lg++ + ++ +a++++ ++ ak+  d++k  ++ v 
    EFC38261.1 510 KLGMALGSKGQHDESIAFFERSFELAKKTKDNAKIGEAKVR 550
                   69****************************99965555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (571 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1095  (0.0610742); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.78u 0.27s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 3120.86
//
Query:       EFC38262.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.9e-19   67.7   0.8    6.1e-18   65.1   0.5    1.9  2  Pkinase         Protein kinase domain
    9.4e-07   28.6   0.1    1.2e-06   28.3   0.1    1.2  1  Choline_kinase  Choline/ethanolamine kinase
    3.9e-05   23.1   0.0    5.2e-05   22.7   0.0    1.3  1  Pkinase_Tyr     Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.1   0.5     1e-21   6.1e-18      60     200 ..      68     201 ..      58     222 .. 0.81
   2 ?    1.7   0.0     0.022   1.3e+02     236     264 .]     207     235 ..     198     235 .. 0.87

  Alignments for each domain:
  == domain 1  score: 65.1 bits;  conditional E-value: 1e-21
                 B--EEEEEEE....SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTEEEE-SGTTSEESSSSCS CS
     Pkinase  60 ivrlyevfee....kdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelesssk 153
                 +++ y++ ++    kde++lv+ey +g+ ++         + ++++++++q+l++ +y+ ++ + H  lKp+Ni +d ++ +lKi+D   ++++  +  
  EFC38262.1  68 VIKKYSFEKSydlkKDEITLVMEYKNGTGYTP-------KNFKDIQSYMSQLLNACAYMRHNFVTHHNLKPDNIVYDrNDSVLKIIDVEYCRHVAGRF- 158
                 5555555555677799**********884433.......34579*********************************88888*************976. PP

                 BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTS CS
     Pkinase 154 ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsge 200
                     +g + Y APE  ++  +++++D++s+G+i+ +++  ++ ++++
  EFC38262.1 159 ---NIGNPFYKAPEKENYGTVGPSSDMYSVGIIFRNIVK-SNYYEKT 201
                 ...9******************************99954.4455533 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.022
                 HHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 236 eakdllkkllkkdpkkRltaeellqhpyl 264
                  a  l+ k+l+k ++ R+    +l+h+++
  EFC38262.1 207 LADALILKMLSKYKEVRIDPLRALEHEFF 235
                 57789**********************98 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.1     2e-10   1.2e-06      98     189 ..      70     166 ..       8     181 .. 0.75

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 2e-10
                     HHH......HHCCS.TT..ECHHGGCCHCCCTHHHHHHHHHTHHHHHHCHGG-EEEE-S--SGGGEEE.-CTTEEEE--GTT-EEEEHHHHHHHH CS
  Choline_kinase  98 qkw......llnkeaqtkakkekkkkqlklinledlekelekleklleelespvvfcHnDlqegNillnkeekklvlIDFEYagynyrgfDlanh 186
                     +k+       l+k++ t   + k+ + ++  n++d+++ +++l + + +++++ v  Hn l + Ni+++ +++ l +ID EY+      f+++n 
      EFC38262.1  70 KKYsfeksyDLKKDEITLVMEYKNGTGYTPKNFKDIQSYMSQLLNACAYMRHNFVTHHN-LKPDNIVYDRNDSVLKIIDVEYCRHVAGRFNIGNP 163
                     44433333333333444444555566667778999999999999999999999998777.**********************************9 PP

                     HHH CS
  Choline_kinase 187 fiE 189
                     f  
      EFC38262.1 164 FYK 166
                     965 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   8.7e-09   5.2e-05     101     200 ..     101     194 ..      39     221 .. 0.87

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 8.7e-09
                  BHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETT.EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHH CS
  Pkinase_Tyr 101 tlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenk.vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwE 197
                  ++kd+ s++ q+ ++++y+ ++ + H +l   N++ ++n+ v ki D   +r++       + + +  +  + apE  +++++  +sD++s G++   
   EFC38262.1 101 NFKDIQSYMSQLLNACAYMRHNFVTHHNLKPDNIVYDRNDsVLKIIDVEYCRHV-------AGRFNIGNPFYKAPEKENYGTVGPSSDMYSVGIIFRN 191
                  6789999******************************976588*********99.......555566778899*********************9988 PP

                  HHT CS
  Pkinase_Tyr 198 ift 200
                  i++
   EFC38262.1 192 IVK 194
                  887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       558  (0.0311228); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1370.77
//
Query:       EFC38263.1  [L=546]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-09   38.0   3.0    4.8e-09   36.3   0.5    2.4  2  Myb_DNA-binding  Myb-like DNA-binding domain
    8.9e-09   35.0   8.1    1.9e-08   33.9   8.1    1.6  1  ZZ               Zinc finger, ZZ type
    0.00015   22.0   5.4    0.00034   20.8   0.5    2.8  3  Myb_DNA-bind_6   Myb-like DNA-binding domain
     0.0016   18.7   2.7     0.0081   16.5   0.0    3.1  3  SWIRM            SWIRM domain
  ------ inclusion threshold ------
        2.1    8.8  14.0      0.087   13.2   8.1    1.8  2  C1_2             C1 domain


Domain annotation for each model (and alignments):
>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.3   0.5   1.3e-12   4.8e-09       3      45 ..     114     158 ..     112     159 .. 0.95
   2 ?    1.7   0.1     0.084     3e+02      22      43 ..     347     370 ..     312     371 .. 0.74

  Alignments for each domain:
  == domain 1  score: 36.3 bits;  conditional E-value: 1.3e-12
                      SSBHHHHHHHHHHHHHHT.TCHHHHHHHHT.SS-HHHHHHHHHHH CS
  Myb_DNA-binding   3 kWteeEdelLleavkkhG.nrWkkIaerlg.gRtekqcrsrwrny 45 
                       Wt++E+++Lle++ + G ++W  Iae++g  +++ +c +++ ++
       EFC38263.1 114 TWTADEELQLLEGISQKGlGNWLDIAEHIGkQKSKYECEYHYWTL 158
                      6*****************************99**********875 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.084
                      CHHHHHHHHT..SS-HHHHHHHHH CS
  Myb_DNA-binding  22 rWkkIaerlg..gRtekqcrsrwr 43 
                      +Wk+I+      ++ ek+   r+r
       EFC38263.1 347 DWKRISAVEKkrNKMEKELYQRYR 370
                      6****8877778999999999886 PP

>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   8.1   5.4e-12   1.9e-08       3      44 ..      53      95 ..      51      96 .. 0.94

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 5.4e-12
                S-EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH..H---SS CS
          ZZ  3 kkytCdgCseapligvRyhclrcsdYDLCqsCfst.hkagkhk 44
                + ++Cd C+++ +   R +c+ c+++DLC  Cf+    +++hk
  EFC38263.1 53 DRFHCDYCKKDISSSLRIRCAECDEFDLCADCFFVgVETKEHK 95
                679*******************************999999997 PP

>> Myb_DNA-bind_6  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.5   9.4e-08   0.00034       1      43 [.     115     158 ..     115     178 .. 0.87
   2 ?    2.6   0.3     0.045   1.6e+02       2      40 ..     312     370 ..     312     380 .. 0.73
   3 ?   -3.2   0.0         3   1.1e+04       1      20 [.     511     531 ..     511     531 .. 0.81

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 9.4e-08
  Myb_DNA-bind_6   1 WteeEdeiLlklvekyg.ndWknIaealn.rRtpkqcfdrwknkL 43 
                     Wt++E+  Ll++ ++ g  +W  Iae+++ ++++ +c +++ + L
      EFC38263.1 115 WTADEELQLLEGISQKGlGNWLDIAEHIGkQKSKYECEYHYWT-L 158
                     *****************66*********55********99976.5 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.045
  Myb_DNA-bind_6   2 teeEdeiLlklvekygn..................dWknIaealn..rRtpkqcfdrwk 40 
                     t+eE+e+ l++ + y++                  dWk I+   +  ++  k++ +r++
      EFC38263.1 312 TPEEKEKKLDYLRLYEFrlsererrkkfaverglfDWKRISAVEKkrNKMEKELYQRYR 370
                     67777777777777765566667777777777888*****9988645566677777775 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 3
  Myb_DNA-bind_6   1 WteeEdeiLlklveky.gndW 20 
                     +t+ E++ + k++  + +n+W
      EFC38263.1 511 FTDFEKDVISKIHDFFvSNNW 531
                     799999999999887767788 PP

>> SWIRM  SWIRM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       3.7   1.3e+04      35      57 ..      39      60 ..      33      70 .. 0.60
   2 ?    0.3   0.4      0.26   9.2e+02      35      48 ..     394     409 ..     342     435 .. 0.58
   3 !   16.5   0.0   2.2e-06    0.0081      11      87 ..     467     532 ..     457     532 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.7
       SWIRM 35 kiRnkiialyrenpkeyltvtea 57
                k +n i+++   +   ++  + +
  EFC38263.1 39 KAKNSIFQKDDLETD-RFHCDYC 60
                667777777665533.3555555 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.26
       SWIRM  35 kiRnki..ialyrenp 48 
                 kiRn+i  +++yr n 
  EFC38263.1 394 KIRNRIqqLKEYRANG 409
                 6777773333444443 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 2.2e-06
       SWIRM  11 lhpiEkellselfngkdktpeeYlkiRnkiialyrenpkeyltvteaqkalkrrrltgidvnllsrihefLerwGlI 87 
                 l++ E+  +  l       p++Y+ i++ +i++  +     +++  a+k+++       + +++s+ih+f+ ++++I
  EFC38263.1 467 LSKRERSFCVGLQ----LYPKHYILIKDVLIRESVQ--LGFVSKATACKLFT-----DFEKDVISKIHDFFVSNNWI 532
                 6667777777777....99****************9..67888888867776.....558899*************9 PP

>> C1_2  C1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   8.1   2.4e-05     0.087      11      46 ..      47      84 ..      37      85 .. 0.84
   2 ?   -4.3   0.3         5   1.8e+04      31      36 ..     147     152 ..     144     153 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.4e-05
        C1_2 11 kgedssesfnCsaCgrkidgff.YsCseCd.fslhvrC 46
                k++ + ++f+C+ C+++i+++   +C eCd f l+ +C
  EFC38263.1 47 KDDLETDRFHCDYCKKDISSSLrIRCAECDeFDLCADC 84
                56678899*********666666******77******* PP

  == domain 2  score: -4.3 bits;  conditional E-value: 5
        C1_2  31 ffYsCs 36 
                 ++Y+C+
  EFC38263.1 147 SKYECE 152
                 458884 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (546 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       651  (0.0363099); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 3269.27
//
Query:       EFC38264.1  [L=410]
Description: hypothetical protein NAEGRDRAFT_73977 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.7e-20   71.4   1.6    2.7e-13   49.9   2.5    3.1  2  Cu-oxidase_2  Multicopper oxidase
    6.7e-14   51.9   0.4    6.1e-08   32.7   0.0    3.5  2  Cu-oxidase_3  Multicopper oxidase


Domain annotation for each model (and alignments):
>> Cu-oxidase_2  Multicopper oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   1.2e-06     0.011      30     120 ..     124     221 ..      98     239 .. 0.81
   2 !   49.9   2.5     3e-17   2.7e-13      23     133 ..     304     400 ..     280     404 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.2e-06
                   TSSEEEEEETTEEEEEEEEE-SSS-EEEEESS-EEEEEEEEECCCCCCTCCSSGCCGSSCBSEEEE-TTEEEEEEEES..S-EE..........EEE CS
  Cu-oxidase_2  30 entnvitlpkgevveiviqnntklpHPfHlHGhdfqvlgrgpgndpeedpksynlenpvrrdtvqvppggwvairfka.dnpGv..........wll 115
                      ++i+++ ge ++i ++n  ++p  +H HG++ +  ++g++    ++ k++++ +p++ d v+   g+++ + f++ d +G+          w++
    EFC38264.1 124 IVGPIIRAEVGEQIRILFKNALEFPAGIHPHGVHYDKQSEGAAY--VDNDKDMSFATPGSGDAVAA--GATFEYIFNVpDRAGPldnsplssipWMY 216
                   5567899999***********************99976555555..7788889999******9998..88888888876899999************ PP

                   EESSH CS
  Cu-oxidase_2 116 HCHil 120
                   H+H l
    EFC38264.1 217 HSHAL 221
                   ***87 PP

  == domain 2  score: 49.9 bits;  conditional E-value: 3e-17
                   E...ETCCTTTSSEEEEEETTEEEEEEEEE-SSS.-EEEEESS-EEEEEEEEECCCCCCTCCSSGCCGSSCBSEEEE-TTEEEEEEEES.S-EEEEE CS
  Cu-oxidase_2  23 t...ngeefsentnvitlpkgevveiviqnntkl.pHPfHlHGhdfqvlgrgpgndpeedpksynlenpvrrdtvqvppggwvairfkadnpGvwll 115
                   +   ng +  +n   +++ +ge+v++++   +++  HP+H+HG+    +g + g                  dtv v pg   a+ +++dnpG wl+
    EFC38264.1 304 KdsiNGYMSVNNIGGFDMCQGERVRWYVGTIGNVdLHPVHWHGN----VGLEDGI--------------RLVDTVFVGPGIARALDMDVDNPGNWLF 382
                   2344666555688899999***********999999********....7777776..............347************************* PP

                   EESSHHHHHTT-EEEEEE CS
  Cu-oxidase_2 116 HCHilwHldqGmalqfvv 133
                   HCHi+ H   Gm+  f v
    EFC38264.1 383 HCHIDNHHMDGMVDIFKV 400
                   ************977776 PP

>> Cu-oxidase_3  Multicopper oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   0.0   6.8e-12   6.1e-08      23     117 ..     123     240 ..     101     241 .. 0.76
   2 !   13.8   0.3     5e-06     0.045      51     117 ..     342     403 ..     334     405 .. 0.90

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 6.8e-12
                   SSBS-EEEEETT-EEEEEEEE-SSS-B-EEEET--S-GG.....GSCSGG............G-B-TT-EEEEEEE--S-SEEE..........EEE CS
  Cu-oxidase_3  23 qfpgptievregdtvvvnvtNkldentsihwhGlqqrktswmDGvpgvtq............cpiqpgesftyrftvkqqagtl..........wYh 97 
                    ++gp i+++ g+++++ ++N+l+ +  ih hG++ +k+  + G+++v +            +++++g++f+y f+v ++ag l          +Yh
    EFC38264.1 123 GIVGPIIRAEVGEQIRILFKNALEFPAGIHPHGVHYDKQ--SEGAAYVDNdkdmsfatpgsgDAVAAGATFEYIFNVPDRAGPLdnsplssipwMYH 217
                   689**********************************99..88888775422222222222268***************9996444444445548** PP

                   E--TT...HHHTT-EEEEEEE-H CS
  Cu-oxidase_3  98 shlsl...qqaaGlaGaiiiedk 117
                   sh+     + +aGl G+i+i  k
    EFC38264.1 218 SHALDepaETQAGLIGFIVITRK 240
                   ***99997777********9865 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 5e-06
                   EEEET--S-GG.....GSCSGGG-B-TT-EEEEEEE--S-SEEEEEEE--TTHHHTT-EEEEEEE-H CS
  Cu-oxidase_3  51 ihwhGlqqrktswmDGvpgvtqcpiqpgesftyrftvkqqagtlwYhshlslqqaaGlaGaiiiedk 117
                   +hwhG         DG+  v +  + pg  +   ++v++  g  ++h h+++++++G++ ++ ++ k
    EFC38264.1 342 VHWHGNVG----LEDGIRLVDTVFVGPGIARALDMDVDN-PGNWLFHCHIDNHHMDGMVDIFKVYHK 403
                   89999653....457************************.*******************99999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       414  (0.0230911); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2425.85
//
Query:       EFC38265.1  [L=325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0015   18.4   0.5     0.0039   17.0   0.5    1.7  1  TENA_THI-4  TENA/THI-4/PQQC family
  ------ inclusion threshold ------
       0.06   13.3   0.3       0.18   11.8   0.3    1.9  1  Paz_1       PAZ domain
        1.1    8.5   8.7       0.19   11.0   1.0    2.7  3  6PF2K       6-phosphofructo-2-kinase


Domain annotation for each model (and alignments):
>> TENA_THI-4  TENA/THI-4/PQQC family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.5   6.5e-07    0.0039      10      59 ..     268     320 ..     262     323 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 6.5e-07
                 HHHC.SHHHHHHHTT-S-HH.HHHHHHH.HHHHHHHHHHHHHHHHHHC-SSHH CS
  TENA_THI-4  10 eyin.HpFvkalakGtlpre.qfqayvi.qdylylknfvrvlaiilskssdle 59 
                 +y   H++ +++ +Gt+p++  +q+++  q y++l+++  ++ +i+s+ ++++
  EFC38265.1 268 QYLTaHEYFQQINSGTVPTDeNIQKFLQsQMYHFLTEYYEKFKLIVSSKKTIS 320
                 45556************99537*****6488************9999999875 PP

>> Paz_1  PAZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.3     3e-05      0.18      48      85 ..      78     115 ..      52     124 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3e-05
                 HHH-SSHHHHHHHHHHHHSHHHHHHSEEEEETTS-EEE CS
       Paz_1  48 mersthksskkaweellknrelrekaflvvlekgytyp 85 
                  er   k  +ka+e++ k  elr + +l vl++  ty 
  EFC38265.1  78 EEREKIKYKNKAFEKVEKGSELRSQIMLRVLKQQVTYR 115
                 589999999**************************996 PP

>> 6PF2K  6-phosphofructo-2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.21   1.2e+03      61      98 ..      86     121 ..      71     150 .. 0.62
   2 ?    1.6   0.1     0.025   1.5e+02      57      93 ..     203     239 ..     200     244 .. 0.87
   3 ?   11.0   1.0   3.2e-05      0.19     169     216 ..     255     302 ..     246     308 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.21
                 --GGGGSTT-HHHHHHHHHHHHHHHHHHHHHHHTS--S CS
       6PF2K  61 sdaeffrpdneealklreklalaalkdllaylneeegq 98 
                 ++  f++   e++ +lr+++ l++lk+ ++y +++  +
  EFC38265.1  86 KNKAFEK--VEKGSELRSQIMLRVLKQQVTYRKQKRLK 121
                 4444433..34666777777777777766665555444 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.025
                 HSS---GGGGSTT-HHHHHHHHHHHHHHHHHHHHHHH CS
       6PF2K  57 skalsdaeffrpdneealklreklalaalkdllayln 93 
                 s++ ++++  +++ ++  +++ek+  a+l+ + ++l 
  EFC38265.1 203 SNQVKNVKTKSFTQTKWKQVQEKISSATLQTISRFLR 239
                 5667889999999999999************999997 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 3.2e-05
                 HHHHHTT-----TTTTTTSEEEEEETTTTEEEEE---SHHHHHHHHHH CS
       6PF2K 169 lenyekqyeplddeedeelsyIkvidvgkslvvnnvqgylqsrivyyl 216
                 ++ y+  y+ ld +    ++y ++i+ g+  + +n+q++lqs++ ++l
  EFC38265.1 255 IHYYQMPYKILDGQYLTAHEYFQQINSGTVPTDENIQKFLQSQMYHFL 302
                 6789999************************************99887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1529  (0.0852808); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.36s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 1775.48
//
Query:       EFC38266.1  [L=809]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.8e-52  177.8  21.3    2.8e-52  177.8  21.3    2.1  2  CitMHS         Citrate transporter
    8.1e-16   58.1  39.1    5.6e-11   42.2  15.2    2.7  2  Na_sulph_symp  Sodium:sulfate symporter transmembrane region
    8.3e-10   38.6  30.8    5.3e-06   26.0   6.7    2.1  2  ArsB           Arsenical pump membrane protein


Domain annotation for each model (and alignments):
>> CitMHS  Citrate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  177.8  21.3   4.7e-56   2.8e-52       1     300 []     312     746 ..     312     746 .. 0.67
   2 ?   -0.3   0.7     0.081   4.8e+02     249     276 ..     778     805 ..     747     808 .. 0.54

  Alignments for each domain:
  == domain 1  score: 177.8 bits;  conditional E-value: 4.7e-56
                 xxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxx RF
      CitMHS   1 lvllileklrldvvallvlvll.........vltieealsgiaspiillllgamiigaaleetGlfdrlaakllrlaggkrd.llvllvlltallsafv 89 
                 ++l+i+e ++++v+++l+  ++           t++e+ +++  +++ ll+g+mi++++ + tG+f+++a   ++l++g+ + l v+l+l+ta++saf+
  EFC38266.1 312 YILIIFELVHRTVASMLGSFIVlavmafinqRPTLKEICEWMEYDTLTLLFGMMIMVGIFANTGFFEWIALVAYKLSKGSVWrLTVILCLFTAVVSAFL 410
                 89******99999999888877787787777777777************************************************************** PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx.............................................. RF
      CitMHS  90 sndgvvlimipivlslakrlkklppl.lliplalaaniggaltpiGtpttraa.............................................. 141
                 +n++++l+++p++l+l+  + + +p+  +i  ++++nigg++t +G+p+++ +                                              
  EFC38266.1 411 DNVTTILLVVPVTLRLCSVV-NVSPIpIVISEVIFSNIGGVATAVGDPPIVIIvnhpaikalnigfldisiylapcaviigactilpirllnwnlfktk 508
                 ******************75.555555*********************777667777777777777733333333333333333333333333333333 PP

                 ...................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..... RF
      CitMHS 142 ...................................arpglslpnllllalllvgllplvllfmfgvalalpvnapkvkkqkaiieaiarsllpv..... 200
                                                    +                                                               
  EFC38266.1 509 pdidneklqrekeieiweqtlrktrgngieemkvkE---------------------------------------------------------Slqlhi 550
                 333333333333333333333333333333322221.........................................................022222 PP

                 ...............................................................................xxxxxxx........xxxxx RF
      CitMHS 201 ...............................................................................atillla........ykkve 212
                                                                                                +t+lll         ++kve
  EFC38266.1 551 vnlksqleeyltsrgsnvnngklgakemkelseqyfihnprlfiicsailiiciiffflesfihhyvqtslaevaiigaITMLLLSgiddleevIEKVE 649
                 22222233333333333333333333333333333333333333333333333333333333333333333332332224455444************* PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........x.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxx RF
      CitMHS 213 WsvlllfaGvfllvgaleqtGilealadllga.........g.gplvalalvlgliallsafisnvavaalmapialgmapalgl.lspsplalalavg 300
                 W +ll+f+ +f+l+++l+++G+++ +++++ +         +  ++va+++++++++++safi+n ++a  m+pi+l++a    + l++ p+++ala+g
  EFC38266.1 650 WTTLLFFGSLFILMEGLTKLGLIDFIGTWT-SyvislvpagDlRLFVAITVLVWVSGIVSAFIDNLPYASAMIPIVLKLAEE-PTnLPVRPILWALALG 746
                 ****************************99.448999998537999999999****************************95.33499*********97 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.081
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      CitMHS 249 valalvlgliallsafisnvavaalmap 276
                 v ++   + ++lls++isn+ +++l ++
  EFC38266.1 778 VQFMKYGFPCMLLSLLISNIYLVILHVA 805
                 3223335556679999999988766555 PP

>> Na_sulph_symp  Sodium:sulfate symporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7  15.9     3e-08   0.00018     272     441 ..     306     471 ..     293     501 .. 0.78
   2 !   42.2  15.2   9.4e-15   5.6e-11     273     457 ..     597     794 ..     592     806 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 3e-08
  Na_sulph_symp 272 llilfvlllllWifgeslnidattvaivvlvillllr.......vldWkDivkqktaWntllllgglialakllersgliewlgnklttslsglsp 360
                    l+++fv +l++    +   +     +++vl+++  ++       + +W       + ++tl+ll g++ +  +  ++g++ew++ +  ++++g ++
     EFC38266.1 306 LVLVFVYILIIFELVHRT-VASMLGSFIVLAVMAFINqrptlkeICEW-------MEYDTLTLLFGMMIMVGIFANTGFFEWIALVAYKLSKGSVW 393
                    455555555444433333.66666677888888666655544444444.......578*****9999999**************999999999998 PP

  Na_sulph_symp 361 avaiiiilslfvlvhylfaSatAttaallpillavaqaipgappllvalllalatslagfllpyatgpnpivfgagylkvk 441
                     +   +il lf +v   f  ++ t+  ++p+ l +  ++  + p+ ++++ ++ ++++g+ + ++ +p +i+     +k  
     EFC38266.1 394 RL--TVILCLFTAVVSAFLDNVTTILLVVPVTLRLCSVV-NVSPIPIVISEVIFSNIGGVATAVGDPPIVIIVNHPAIKAL 471
                    76..57899999**************************9.7778888888888899*************999877666655 PP

  == domain 2  score: 42.2 bits;  conditional E-value: 9.4e-15
  Na_sulph_symp 273 lilfvlllllWifgesln....idattvaivvlvillllrvldWkDivkqktaWntllllgglialakllersgliewlgnklttsls.glspava 363
                    ++++++ +++ + +++++     + + vai++ +++lll+ +d  + v +k  W tll++g+l  l ++l+++gli+++g   +   s    + + 
     EFC38266.1 597 SAILIICIIFFFLESFIHhyvqTSLAEVAIIGAITMLLLSGIDDLEEVIEKVEWTTLLFFGSLFILMEGLTKLGLIDFIGTWTSYVISlVPAGDLR 692
                    578889999999999998996678899***********997776668889******************************9877766643444555 PP

  Na_sulph_symp 364 iiiilslfvl...vhylfaSatAttaallpillavaqaipgappllvalllalatslagfllpyatgpnpivfgagylkvkdy.....wrlGfils 451
                    +++ ++++v    +   f  +  + +a++pi+l +a+  +  p   +  +lal t l+g  + +++++n+++ g+  ++ +++      + Gf+  
     EFC38266.1 693 LFVAITVLVWvsgIVSAFIDNLPYASAMIPIVLKLAEEPTNLPVRPILWALALGTCLGGNGTIIGASANVVAAGICENSGHKMgfvqfMKYGFPCM 788
                    55555555441124567999******************99999999999************************99887776651111145555555 PP

  Na_sulph_symp 452 iiglli 457
                    +++lli
     EFC38266.1 789 LLSLLI 794
                    544444 PP

>> ArsB  Arsenical pump membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4  16.2   1.8e-07    0.0011       5     173 ..     307     478 ..     303     507 .. 0.69
   2 !   26.0   6.7   8.9e-10   5.3e-06     216     421 ..     587     801 ..     553     803 .. 0.85

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.8e-07
        ArsB   5 iflltlvlviwqpknlsigwsacggavlaliagvvnfhdvltvtgivwnatlafv.aiilislildnigffewaalhmakaakgygvrmfvyvsllgai 102
                 ++++  +l+i++    ++        vla++a + +   +  +   +   tl+++  ++++  i+ n gffew al   k +kg   r+ v + l+ a+
  EFC38266.1 307 VLVFVYILIIFELVHRTVASMLGSFIVLAVMAFINQRPTLKEICEWMEYDTLTLLfGMMIMVGIFANTGFFEWIALVAYKLSKGSVWRLTVILCLFTAV 405
                 555556666666666666555555566666665544444445555555555554413444456899********************************* PP

        ArsB 103 vaalfandgaaliltpivlamvralhfne.klvfpfiias..gfiadttslpfvvsnlvnivsadyfhitfidy 173
                 v+a++ n  + l++ p+ l +   + +    +v+  +i s  g +a +   p +v  +vn  +   + i f+d 
  EFC38266.1 406 VSAFLDNVTTILLVVPVTLRLCSVVNVSPiPIVISEVIFSniGGVATAVGDPPIV-IIVNHPAIKALNIGFLDI 478
                 *******************999888776414566666655223344444444443.356666666666666665 PP

  == domain 2  score: 26.0 bits;  conditional E-value: 8.9e-10
        ArsB 216 ikdqnmfrlswyilgllligyfaseffsipvsvvagsiaiifliaaqk.spavhtkkvvkeapwaivffsigmyvvvygvrnagltdvl....sdviq. 308
                 i++  +f +   il + +i +f   f+   v      +aii  i+    s     ++v+++  w+ ++f   +++++ g+ + gl d +    s vi  
  EFC38266.1 587 IHNPRLFIICSAILIICIIFFFLESFIHHYVQTSLAEVAIIGAITMLLlSGIDDLEEVIEKVEWTTLLFFGSLFILMEGLTKLGLIDFIgtwtSYVISl 685
                 667778999999*********************99******9998865156667899***********999****************874444667762 PP

        ArsB 309 .aaadqglfagtigmgfiaailssimnnlp..tvmida.laiagtdthgmmrealiyanvigsdlgpkitpigslatllwlhvlshkgmkiswgtyfkt 403
                   a d  lf     + +++ i+s+ ++nlp  + mi   l +a   t   +r  +++a  +g+ lg + t ig+ a ++   +    g k+ +  ++k 
  EFC38266.1 686 vPAGDLRLFVAITVLVWVSGIVSAFIDNLPyaSAMIPIvLKLAEEPTNLPVR-PILWALALGTCLGGNGTIIGASANVVAAGICENSGHKMGFVQFMKY 783
                 25899************************95446887615666666665555.6789****************************************** PP

        ArsB 404 giiltiptllitlvglyi 421
                 g    + +lli+ + l i
  EFC38266.1 784 GFPCMLLSLLISNIYLVI 801
                 *99999999998877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (809 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1545  (0.0861732); expected 358.6 (0.02)
Passed bias filter:                      579  (0.032294); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.84u 0.34s 00:00:01.18 Elapsed: 00:00:00.52
# Mc/sec: 4680.26
//
Query:       EFC38267.1  [L=368]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.039   14.1   1.5      0.039   14.1   1.5    2.2  2  DUF4710   Domain of unknown function (DUF4710)


Domain annotation for each model (and alignments):
>> DUF4710  Domain of unknown function (DUF4710)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   1.5   2.2e-06     0.039      25      72 ..       8      56 ..       4      59 .. 0.81
   2 ?   -3.1   0.1      0.48   8.7e+03      32      41 ..     163     172 ..     144     174 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.2e-06
     DUF4710 25 qkeakeekkkkkkqklKKyrKnvgKalrlswrcLvl..GlqnlaaaYstP 72
                q + ke+kk kkk k+KK +K + K l  s   Lv    + ++ ++Ys+P
  EFC38267.1  8 QPTSKEDKKIKKKVKKKK-QKDLQKSLEASLGNLVSpeEITQFFNLYSSP 56
                456778888888877666.89************99866788999999998 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.48
     DUF4710  32 kkkkkkqklK 41 
                 ++kk ++k K
  EFC38267.1 163 EEKKDQEKIK 172
                 3344444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (368 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1279  (0.0713369); expected 358.6 (0.02)
Passed bias filter:                      612  (0.0341346); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 2395.84
//
Query:       EFC38268.1  [L=574]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.6e-10   37.9   0.0     0.0028   17.7   0.0    3.5  2  TPR_8        Tetratricopeptide repeat
    9.5e-09   34.7   0.2    0.00053   19.9   0.0    3.1  2  TPR_2        Tetratricopeptide repeat
      5e-08   32.4   0.0    0.00029   20.5   0.0    2.9  2  TPR_1        Tetratricopeptide repeat
      3e-05   23.6   0.1     0.0023   17.6   0.0    2.9  2  TPR_11       TPR repeat
    0.00063   20.4   0.0      0.035   14.9   0.0    2.6  2  TPR_14       Tetratricopeptide repeat
    0.00081   19.6   0.0        2.6    8.4   0.0    2.6  2  TPR_12       Tetratricopeptide repeat
     0.0046   16.9   0.0        1.1    9.5   0.1    2.8  2  TPR_7        Tetratricopeptide repeat
     0.0065   17.0   0.0        1.1    9.8   0.0    2.5  2  TPR_19       Tetratricopeptide repeat
  ------ inclusion threshold ------
       0.01   15.9   0.0        5.9    7.1   0.0    2.4  2  TPR_9        Tetratricopeptide repeat
      0.018   15.6   0.1          2    9.2   0.1    3.4  2  TPR_6        Tetratricopeptide repeat
      0.019   15.3   1.1         16    6.2   0.0    3.2  2  TPR_17       Tetratricopeptide repeat
      0.034   13.5   0.3       0.11   11.8   0.3    1.9  1  PhoU_div     Protein of unknown function DUF47
      0.038   14.7   0.0         11    6.7   0.0    2.5  2  TPR_16       Tetratricopeptide repeat
      0.077   13.1   1.3         18    5.5   0.1    3.3  3  Fis1_TPR_C   Fis1 C-terminal tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   2.2e-06    0.0028       7      34 .]     298     325 ..     296     325 .. 0.94
   2 !   16.2   0.1     7e-06    0.0089       4      32 ..     434     462 ..     433     464 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 2.2e-06
                 HHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   7 lgsiylklgdyeeAkeyyekaleldpdn 34 
                  gsiy   g++ eA++++++a+e+dp+n
  EFC38268.1 298 RGSIYVCEGNLREAEKSLNRAIEIDPNN 325
                 6999**********************97 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 7e-06
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekaleldp 32 
                 ++n +++y +l+dy +A+++ e+ l+++ 
  EFC38268.1 434 LFNRARLYYSLEDYTNAVATVEQLLSIKF 462
                 699***********************985 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   4.1e-07   0.00053       7      34 .]     298     325 ..     296     325 .. 0.96
   2 !   11.4   0.1   0.00022      0.28       4      30 ..     434     460 ..     432     462 .. 0.92

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 4.1e-07
       TPR_2   7 lGlayyklgdyeeAleafekAleldPnn 34 
                 +G +y   g++ eA++ +++A+e+dPnn
  EFC38268.1 298 RGSIYVCEGNLREAEKSLNRAIEIDPNN 325
                 7999***********************8 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00022
       TPR_2   4 lynlGlayyklgdyeeAleafekAlel 30 
                 l+n++++yy l dy  A++  e+ l++
  EFC38268.1 434 LFNRARLYYSLEDYTNAVATVEQLLSI 460
                 89*****************99999976 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   2.2e-07   0.00029       7      34 .]     298     325 ..     297     325 .. 0.96
   2 !    8.6   0.0    0.0014       1.7       4      22 ..     434     452 ..     434     461 .. 0.88

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 2.2e-07
                 HHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   7 lGnayfklgkydeAleyyekALelnPnn 34 
                 +G +y   g++ eA++  ++A+e++Pnn
  EFC38268.1 298 RGSIYVCEGNLREAEKSLNRAIEIDPNN 325
                 79999**********************8 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0014
                 HHHHHHHHHHTT-HHHHHH CS
       TPR_1   4 lynlGnayfklgkydeAle 22 
                 l+n++ +y++l++y  A++
  EFC38268.1 434 LFNRARLYYSLEDYTNAVA 452
                 68***************86 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   1.8e-06    0.0023       1      28 [.     299     326 ..     299     329 .. 0.94
   2 ?    2.7   0.1      0.08     1e+02       2      16 ..     439     453 ..     438     461 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.8e-06
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdna 28 
                 G +y+  G++ eA +++++A+++dP+n+
  EFC38268.1 299 GSIYVCEGNLREAEKSLNRAIEIDPNNV 326
                 8899***********************8 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.08
      TPR_11   2 dayyeqGkyeeAiea 16 
                 ++yy++ +y++A++ 
  EFC38268.1 439 RLYYSLEDYTNAVAT 453
                 68**********986 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   2.8e-05     0.035       7      37 ..     298     328 ..     296     334 .. 0.87
   2 ?    2.3   0.0       0.3   3.9e+02       7      29 ..     437     459 ..     434     468 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.8e-05
      TPR_14   7 laeallalGdpdeAiallrralalaPddaea 37 
                 +++++   G+++eA++ l+ra++ +P++  a
  EFC38268.1 298 RGSIYVCEGNLREAEKSLNRAIEIDPNNVHA 328
                 6789999*******************99765 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.3
      TPR_14   7 laeallalGdpdeAiallrrala 29 
                 +a++++ l+d+  A+a  +++l+
  EFC38268.1 437 RARLYYSLEDYTNAVATVEQLLS 459
                 79*****************9997 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0    0.0021       2.6      52      75 ..     299     322 ..     292     334 .. 0.74
   2 !    8.3   0.0    0.0021       2.7      47      74 ..     433     460 ..     418     481 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0021
      TPR_12  52 grlyralgryeeAlelleealaia 75 
                 g +y   g+++eA++ l++a++i+
  EFC38268.1 299 GSIYVCEGNLREAEKSLNRAIEID 322
                 666667777777777777777765 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0021
      TPR_12  47 tlrnLgrlyralgryeeAlelleealai 74 
                  l+n +rly+ l++y  A++  e+ l i
  EFC38268.1 433 NLFNRARLYYSLEDYTNAVATVEQLLSI 460
                 4666666666666666666666666654 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0      0.04        52       6      33 ..     299     324 ..     298     326 .. 0.87
   2 !    9.5   0.1   0.00083       1.1       2      28 ..     434     460 ..     434     469 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.04
       TPR_7   6 arlysrlGdyeeAielyeqsLaltkdpe 33 
                 +++y+ +G+ +eA++ + +  a++ dp+
  EFC38268.1 299 GSIYVCEGNLREAEKSLNR--AIEIDPN 324
                 89*****************..7777776 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00083
       TPR_7   2 LlnLarlysrlGdyeeAielyeqsLal 28 
                 L+n arly +l dy +A+   eq+L +
  EFC38268.1 434 LFNRARLYYSLEDYTNAVATVEQLLSI 460
                 7899*******************7765 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.0    0.0009       1.1       4      31 ..     305     332 ..     302     340 .. 0.75
   2 ?    4.4   0.0     0.042        53      31      52 ..     437     458 ..     428     464 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.0009
      TPR_19   4 egdyaeAlalleqalqedpknaearllL 31 
                 eg++ eA + l +a++ dp+n  a  lL
  EFC38268.1 305 EGNLREAEKSLNRAIEIDPNNVHASGLL 332
                 6888888888888888888888887755 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.042
      TPR_19  31 LAeallalgqldeAealLdalp 52 
                  A+++++l +++ A a++++l+
  EFC38268.1 437 RARLYYSLEDYTNAVATVEQLL 458
                 599**************99987 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0    0.0046       5.9      35      65 ..     298     328 ..     279     334 .. 0.90
   2 ?    6.3   0.0     0.008        10      31      56 ..     433     458 ..     427     473 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0046
       TPR_9  35 RGlllaqlGclsaAladLeaylalapdapda 65 
                 RG +++  G+l++A + L+++++++p++  a
  EFC38268.1 298 RGSIYVCEGNLREAEKSLNRAIEIDPNNVHA 328
                 9*************************87665 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.008
       TPR_9  31 errdRGlllaqlGclsaAladLeayl 56 
                  ++ R++l++ l+++  A+a  e+ l
  EFC38268.1 433 NLFNRARLYYSLEDYTNAVATVEQLL 458
                 5789**************99888766 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0      0.31     4e+02      14      32 ..     306     324 ..     295     325 .. 0.88
   2 ?    9.2   0.1    0.0015         2       3      27 ..     434     458 ..     433     460 .. 0.90

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.31
                 HHHHHHHHHHHHHHHH-TT CS
       TPR_6  14 gdtdkAlealerlikeYPd 32 
                 g+ ++A + l+r i+  P+
  EFC38268.1 306 GNLREAEKSLNRAIEIDPN 324
                 6999************999 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0015
                 HHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   3 lyklalsyrklgdtdkAlealerli 27 
                 l+++a++y++l d+++A+++ e+l+
  EFC38268.1 434 LFNRARLYYSLEDYTNAVATVEQLL 458
                 89********88*******988887 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.0     0.012        16       3      14 ..     316     327 ..     315     330 .. 0.87
   2 ?    6.1   0.4     0.013        17      10      33 ..     428     451 ..     426     452 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.012
      TPR_17   3 lkaleldPnnad 14 
                  +a+e+dPnn+ 
  EFC38268.1 316 NRAIEIDPNNVH 327
                 69********85 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.013
      TPR_17  10 PnnadaynnLAelllknGdlmtAr 33 
                 P n   ++n+A+l++++ d+  A+
  EFC38268.1 428 PYNILNLFNRARLYYSLEDYTNAV 451
                 6788899************98775 PP

>> PhoU_div  Protein of unknown function DUF47
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.3   8.7e-05      0.11     120     168 ..     518     572 ..     513     574 .] 0.79

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8.7e-05
    PhoU_div 120 lkktveaiealaevieelekll...etalskk...diveeieslEdeiDqlqrkl 168
                 ++++ +   al+++iee +kll   +++++++   ++++ i++lE++i q+q k 
  EFC38268.1 518 IEQSKDQTVALHKCIEEYQKLLtplQKSHKENgnkNLIPHISHLEKKIEQIQAKY 572
                 55666777899999999999862225677766999*****************986 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.0    0.0089        11      10      40 ..     305     332 ..     297     334 .. 0.83
   2 ?    5.4   0.1     0.023        30       2      24 ..     436     458 ..     434     460 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0089
      TPR_16  10 agdyddAaaaleaalkrdpssPdaaeAllll 40 
                  g+ ++A++ l++a++ d   P +++A+ ll
  EFC38268.1 305 EGNLREAEKSLNRAIEID---PNNVHASGLL 332
                 699***************...9999887665 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.023
      TPR_16   2 alaraalragdyddAaaaleaal 24 
                 ++ar+++ + dy+ A+a  e++l
  EFC38268.1 436 NRARLYYSLEDYTNAVATVEQLL 458
                 67888888888888888888776 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.028        35      15      40 ..     306     331 ..     305     333 .. 0.90
   2 ?    5.5   0.1     0.014        18      11      30 ..     441     460 ..     434     462 .. 0.87
   3 ?   -2.2   0.0       3.7   4.7e+03      30      46 ..     518     534 ..     517     535 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.028
                 T-HHHHHHHHHHHHHHTTS-HHHHHH CS
  Fis1_TPR_C  15 geYseArryvdalLeiEPenrQaqsL 40 
                 g+ +eA + +++ +ei+P+n  a  L
  EFC38268.1 306 GNLREAEKSLNRAIEIDPNNVHASGL 331
                 7899****************888776 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.014
                 HHHHT-HHHHHHHHHHHHHH CS
  Fis1_TPR_C  11 hyklgeYseArryvdalLei 30 
                 +y l +Y++A   v++lL+i
  EFC38268.1 441 YYSLEDYTNAVATVEQLLSI 460
                 899***************87 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 3.7
                 HTTS-HHHHHHHHHHHH CS
  Fis1_TPR_C  30 iEPenrQaqsLkelied 46 
                 iE +  Q  +L++ ie+
  EFC38268.1 518 IEQSKDQTVALHKCIEE 534
                 56778899*****9995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (574 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1121  (0.0625244); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 3398.42
//
Query:       EFC38269.1  [L=681]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (681 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       975  (0.0543812); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.36s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 3786.09
//
Query:       EFC38270.1  [L=763]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-05   25.4   0.1    4.2e-05   23.7   0.0    1.8  2  NTP_transf_2  Nucleotidyltransferase domain
    0.00059   19.9   0.0     0.0017   18.4   0.0    1.8  1  Polbeta       Polymerase beta, Nucleotidyltransferase
     0.0072   16.5   0.1     0.0072   16.5   0.1    2.7  3  PAP_assoc     Cid1 family poly A polymerase


Domain annotation for each model (and alignments):
>> NTP_transf_2  Nucleotidyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0   7.1e-09   4.2e-05       9      59 ..     197     247 ..     191     290 .. 0.71
   2 ?   -3.5   0.0       2.2   1.3e+04      35      58 ..     705     731 ..     704     741 .. 0.48

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 7.1e-09
                   HHHTTTSEEEEEHHHHCTTSCTTSSEEEEEEESTTCHHH...........HHHEHHHHHHHH CS
  NTP_transf_2   9 kelepvakvvlfGSyarGtalkgSDiDllvvlpeevsre...........kkeegleklaei 59 
                    el  + k +l+GS+a  t+l++ DiDl v++++e + e                      +
    EFC38270.1 197 LELA-NLKTYLYGSVAFKTYLPDGDIDLSVFVSNEEYLElssqnvnnllsH----------Q 247
                   5555.8899**************************8877644333333221..........2 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.2
                   EEEEEESTTCHHH...HHHEHHHHHHH CS
  NTP_transf_2  35 Dllvvlpeevsre...kkeegleklae 58 
                   Dl v+++ +++++   +ke+++ +  +
    EFC38270.1 705 DLTVTYSPSKQKSkknPKENENIDPNK 731
                   666766666554443333333333333 PP

>> Polbeta  Polymerase beta, Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   2.8e-07    0.0017      16      44 ..     204     239 ..     193     287 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 2.8e-07
                 TTEEEEEE-S------EEEEEEEESS-.......-- CS
     Polbeta  16 aylFGSrakgkareeSDiDlavllkek.......ld 44 
                  yl+GS+a +++ ++ DiDl v+++++       ++
  EFC38270.1 204 TYLYGSVAFKTYLPDGDIDLSVFVSNEeylelssQN 239
                 6**************************444332222 PP

>> PAP_assoc  Cid1 family poly A polymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.8       2.2   1.3e+04       2      13 ..     381     392 ..     381     392 .. 0.91
   2 !   16.5   0.1   1.2e-06    0.0072       6      27 ..     401     421 ..     399     435 .. 0.90
   3 ?   -1.4   0.0      0.47   2.8e+03      34      59 ..     460     484 ..     452     487 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.2
                 HHHHHHHHHHHH CS
   PAP_assoc   2 LGeLLigFFeyY 13 
                 L +LL+ +F++Y
  EFC38270.1 381 LTVLLMYMFRLY 392
                 679********9 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 1.2e-06
                 HHHHHHHHHHT--TTTEEEECS CS
   PAP_assoc   6 LigFFeyYgreFdyenvvisir 27 
                 L  F++yY+  Fd++n +isi 
  EFC38270.1 401 LYRFLNYYS-TFDWTNFGISIY 421
                 889******.**********96 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.47
                 HHHHCGCS-SSEECESSSSEBEETTC CS
   PAP_assoc  34 kkekgwesaeskernrfllaIeDPfe 59 
                 k+++g ++ +sk ++ ++l+I DP  
  EFC38270.1 460 KSKYGTVD-SSKTFTIKNLNIVDPLR 484
                 55566665.556788999******75 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (763 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1361  (0.0759105); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.36s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 4390.39
//
Query:       EFC38271.1  [L=528]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.8e-18   66.6   0.0    2.8e-18   66.6   0.0    2.7  3  RNA_lig_T4_1     RNA ligase
  ------ inclusion threshold ------
        1.1    9.6   6.3        2.9    8.3   0.1    2.6  2  Penicillinase_R  Penicillinase repressor
          7    6.7   9.1        4.8    7.3   1.0    3.3  3  DGF-1_C          Dispersed gene family protein 1 of Trypanoso


Domain annotation for each model (and alignments):
>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   3.0      0.22   1.3e+03      69     119 ..      39      87 ..       3     139 .. 0.69
   2 !   66.6   0.0   4.7e-22   2.8e-18       1     220 []     154     351 ..     154     351 .. 0.78
   3 ?   -2.0   0.2      0.44   2.6e+03     148     168 ..     471     490 ..     384     513 .. 0.60

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.22
  RNA_lig_T4_1  69 aSkhsleaeshaevgerllekklekegkteeeLaeelleknlTavfElcdd 119
                    Sk++   ++  +++++ + ++ ++ +++eee ++  ++kn  +v El ++
    EFC38271.1  39 QSKKEE--KKNKQIAKQPVVEEDSEDSNSEEEVQKPTKSKNSRLVTELSKN 87 
                   333333..4555555555555555666667888888888888888887654 PP

  == domain 2  score: 66.6 bits;  conditional E-value: 4.7e-22
  RNA_lig_T4_1   1 eaRGLfteenkeerIvvRgydKFFNinEveetkweeieqktqgpyelteKenGclilisalsdgklvvaSkhsleaeshaevgerllekklekegkt 97 
                   e+RGL++++++++++v+  ++KFFN++E+ + +  +i++k   + +++eK +G+l +++  + g++ + S  ++      + g+  l+++ ++ +k 
    EFC38271.1 154 ECRGLVLDKDNNYKVVCYPFKKFFNYGEKYNASK-DINWK---EARVYEKIDGSLCTLY--YYGDMWWISTTGT------ASGNGYLHNQKRTFDKL 238
                   7**********99***************997765.78777...799*************..6666777777777......56777777777777777 PP

  RNA_lig_T4_1  98 eeeLaee......lleknlTavfElcddsfeehivaypeekagLyLhglnentpefstesseevakfakefg.fiktklitlesleevkkfleevae 187
                   + +L ++        ++n  ++fEl ++  e+ i+   +++++++L+g+++ t+     ++e+   +a++++  +++++  ++s+ +v + + +++ 
    EFC38271.1 239 FWDLWKKlgyqfpDPKENKIYMFELFSN--EHTIIVK-PDRDRIVLLGVRDLTTL----KEEDPVPIAEQMKwECVQSYPLYTSVGMVFDAARNLDP 328
                   77777774444444578999********..6666666.5***********66554....43344455555554468888888888899888887777 PP

  RNA_lig_T4_1 188 tgswegeeiEGfVvrckskkdffFklKfkepyy 220
                   ++       EGfVv++++    f ++K+k+p y
    EFC38271.1 329 SKY------EGFVVCDSN----FNRIKIKSPQY 351
                   776......*******88....889******98 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.44
  RNA_lig_T4_1 148 stesseevakfakefgfiktk 168
                    + ++ee+ k+ k+f++i+++
    EFC38271.1 471 IKVDEEEM-KTSKKFSKIVKQ 490
                   22222333.334444433333 PP

>> Penicillinase_R  Penicillinase repressor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   2.2     0.029   1.7e+02      50     105 ..      40      94 ..      24     101 .. 0.81
   2 ?    8.3   0.1   0.00048       2.9      60     104 ..     428     476 ..     404     483 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.029
                      S-EEEEETTEEEEE----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Penicillinase_R  50 llsrekegrafiYsplvseeeavasavkqlldklfegsvkelvaafveeeklsedd 105
                        ++ek++++++ +p+v ee+  +s +++ ++k  +++ ++lv+++ ++ kl++++
       EFC38271.1  40 SKKEEKKNKQIAKQPVV-EEDSEDSNSEEEVQKPTKSKNSRLVTELSKNVKLDSKE 94 
                      44555666666666666.567899999999********************999988 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00048
                      EEEE----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXX CS
  Penicillinase_R  60 fiYsplvseeeavasavkqlldklfegsvkelvaafveee....klsed 104
                        Y+++ +ee   + a  +++++ +++++++l+ ++++++    k++e+
       EFC38271.1 428 GKYYSNNEEETSNKDAIVNFIQRKCQTDYSKLLISILDKQnpniKVDEE 476
                      57999*********************************99763333333 PP

>> DGF-1_C  Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   1.0    0.0008       4.8      23      48 ..       7      32 ..       3      42 .. 0.91
   2 ?    0.1   0.5      0.13   7.9e+02      25      42 ..      61      78 ..      57      86 .. 0.81
   3 ?    1.9   0.0     0.037   2.2e+02      11      36 ..     346     371 ..     338     382 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0008
     DGF-1_C 23 lrddeesdeelrklhdvtsssyasgt 48
                lr+ e+ dee  k ++  sss +s +
  EFC38271.1  7 LRNKENDDEENTKVKNNNSSSITSSS 32
                9********************99875 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.13
     DGF-1_C 25 ddeesdeelrklhdvtss 42
                +d++s+ee++k+ + + s
  EFC38271.1 61 EDSNSEEEVQKPTKSKNS 78
                68899******9877655 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.037
     DGF-1_C  11 lrePrrggleallrddeesdeelrkl 36 
                 ++ P+  +l  l+  d+e d e++  
  EFC38271.1 346 IKSPQYVALAHLVNKDDEDDSETQDS 371
                 57799999999**9999999999965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (528 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3315  (0.184896); expected 358.6 (0.02)
Passed bias filter:                      697  (0.0388756); expected 358.6 (0.02)
Passed Vit filter:                       130  (0.00725082); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.86u 0.38s 00:00:01.24 Elapsed: 00:00:00.53
# Mc/sec: 3004.98
//
Query:       EFC38272.1  [L=543]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.023   14.5   7.1       0.14   12.0   2.1    2.5  2  Sh_2      Metapneumovirus Small hydrophobic protein
       0.17   11.9   4.4      0.086   12.8   0.8    2.3  2  DUF1910   Domain of unknown function (DUF1910)
       0.84    9.6   6.0      0.085   12.8   0.6    2.1  2  Ninjurin  Ninjurin


Domain annotation for each model (and alignments):
>> Sh_2  Metapneumovirus Small hydrophobic protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   2.1   2.3e-05      0.14      21      83 ..      98     161 ..      92     180 .. 0.72
   2 ?    4.5   0.2    0.0045        27      27      53 ..     322     348 ..     314     378 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.3e-05
        Sh_2  21 kctsclrtlvscavvicailali...flvatiGlsvklavtvkevqickqklselstttaailssv 83 
                 k  +c+ t  sc+  ++ +  l+    l a iGls+   v+ + v++     ++l t ++ + +++
  EFC38272.1  98 KTSTCCSTQFSCISCLSMLALLLniaSLLAIIGLSIASNVSYQSVKVVDV--MSLVTEATNMHTTM 161
                 6789****9999988876655541126889*******9999999988764..44445555555444 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0045
        Sh_2  27 rtlvscavvicailaliflvatiGlsv 53 
                  tl++c v+ica +al+   a + + +
  EFC38272.1 322 STLIACLVLICASIALVIPFAVLIFLI 348
                 577888888888777765444332222 PP

>> DUF1910  Domain of unknown function (DUF1910)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.2      0.29   1.7e+03      93     112 ..     123     142 ..      98     145 .. 0.80
   2 ?   12.8   0.8   1.4e-05     0.086      15      98 ..     425     504 ..     414     523 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.29
     DUF1910  93 qellwllSLaillevedell 112
                  +ll +++L+i  +v+ +++
  EFC38272.1 123 ASLLAIIGLSIASNVSYQSV 142
                 46888999999998886665 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.4e-05
     DUF1910  15 efdkeriaklkekieelsedeeksiqaeikilklsifkykleliiakYSlGesieeleadyeelikeleelwedeagYqellwl 98 
                  +  e i+k +  +  +++++++   +e++ +k++++ + le++ ++Y +G ++++++  y++li + +++ ++e+ Yq +l++
  EFC38272.1 425 LKGGELIEKPN-ALTLKQVNQNEKFLKEVEYMKQQVAFELLECMDMNYDMGINMNQIN--YDDLIHQIDQFNNKEDDYQ-ILDI 504
                 56667778887.66666666666678888***************************95..8999999999988888786.4555 PP

>> Ninjurin  Ninjurin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.6      0.65   3.9e+03      49      66 ..     118     135 ..     100     164 .. 0.52
   2 ?   12.8   0.6   1.4e-05     0.085      37      88 ..     321     369 ..     306     375 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.65
    Ninjurin  49 lSllLqvvvgillilias 66 
                 l l +  +++i+ + ias
  EFC38272.1 118 LLLNIASLLAIIGLSIAS 135
                 333333333333333333 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.4e-05
    Ninjurin  37 skfyiallvLislSllLqvvvgilliliasklnlekekkerrlnklnnaati 88 
                  ++ ia+lvLi++S++L + +++l++li     + + k+e++l k n++ ++
  EFC38272.1 321 RSTLIACLVLICASIALVIPFAVLIFLIG---LISSSKDEKKLFKANTILLF 369
                 55669*******************99963...57777777788888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (543 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       903  (0.0503653); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 3027.63
//
Query:       EFC38273.1  [L=114]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      243  (0.0135535); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.36u 0.21s 00:00:00.56 Elapsed: 00:00:00.37
# Mc/sec: 923.11
//
Query:       EFC38274.1  [L=534]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.034   14.5   0.0      0.065   13.7   0.0    1.4  1  Fer4_23   4Fe-4S iron-sulfur cluster binding domain


Domain annotation for each model (and alignments):
>> Fer4_23  4Fe-4S iron-sulfur cluster binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   3.6e-06     0.065      16      60 ..     165     211 ..     158     225 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.6e-06
     Fer4_23  16 QtGiYavvkkltd...eqaervvealCadsvClkrrlWavekgeklev 60 
                 Q+ ++  v +l++   ++ ++v+e  C ++ C k+ +W+ e+ ek+++
  EFC38274.1 165 QSNMFLTVSNLNRsmnDNMKHVIELAC-PELCYKTGMWDFENCEKFNM 211
                 777888887776422278999999999.9**************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (534 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1797  (0.100229); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.43
# Mc/sec: 3739.54
//
Query:       EFC38275.1  [L=115]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (115 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 744.27
//
Query:       EFC38276.1  [L=669]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.3e-26   92.1  13.7    1.1e-08   35.5   0.1    7.2  6  RCC1       Regulator of chromosome condensation (RCC1) repeat
      1e-22   81.1   0.2    3.1e-22   79.5   0.0    1.9  2  Trypsin    Trypsin
    1.4e-14   53.4  16.3     0.0028   17.4   0.2    6.6  6  RCC1_2     Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.034   15.0   0.0       0.12   13.3   0.0    2.0  2  Trypsin_2  Trypsin-like peptidase domain
       0.17   11.9   0.0       0.39   10.8   0.0    1.5  1  DUF2694    Protein of unknown function (DUF2694)


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.38   1.4e+03       4      13 ..     268     277 ..     266     301 .. 0.89
   2 !   35.5   0.1   3.2e-12   1.1e-08       3      50 .]     328     374 ..     326     374 .. 0.94
   3 !   16.6   1.4   2.6e-06    0.0092      23      50 .]     391     418 ..     377     418 .. 0.83
   4 !   13.2   0.0   2.9e-05       0.1       3      47 ..     424     476 ..     424     477 .. 0.81
   5 !   26.6   0.0   1.9e-09   6.7e-06       1      49 [.     482     528 ..     482     528 .. 0.91
   6 ?    0.2   0.2      0.33   1.2e+03       3      11 ..     533     541 ..     532     544 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.38
                 EEEEE--GGG CS
        RCC1   4 VysWGrndyG 13 
                 +y+WGr d++
  EFC38276.1 268 LYGWGRMDDH 277
                 8****97765 PP

  == domain 2  score: 35.5 bits;  conditional E-value: 3.2e-12
                 EEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtval 50 
                 r+y WGr++++qLG+g++ + l+Pt  ++   +++ +++ G++h++al
  EFC38276.1 328 RLYLWGRGNQYQLGNGKNSDILHPTVHNFVL-ENILDACGGYSHSLAL 374
                 89************************99987.4*************97 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 2.6e-06
                 EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1  23 vlvPtkveglsgnrvvkvacGddhtval 50 
                 + +Pt v +++++++++++cG++h++a+
  EFC38276.1 391 KKTPTVVVFPNNDKIKSISCGHSHNLAV 418
                 357********99************996 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 2.9e-05
                 EEEEEE--GGGTTSS..SS---EEE.....EEE-GGGTTS.-EEEEEEETTEE CS
        RCC1   3 rVysWGrndyGqLGl..gttesvlv.....Ptkveglsgn.rvvkvacGddht 47 
                 r+y WG+n+yG  G+  g   s+++     P +++  +++  ++++++Gd+ +
  EFC38276.1 424 RLYFWGKNQYGEGGNikGACASNPKafierPILISIDNNDfTIISICAGDSTS 476
                 79*************764445554445566****999888*********9865 PP

  == domain 5  score: 26.6 bits;  conditional E-value: 1.9e-09
                 TTEEEEEE--GGGTTSSSS-.--EEEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt.esvlvPtkveglsgnrvvkvacGddhtva 49 
                 +G+VysWG n++  LG+g +  +  +Ptk++     ++  + cGd+ +++
  EFC38276.1 482 KGHVYSWGYNEQSLLGTGISsICIGIPTKISVE---NAERMYCGDQMCFV 528
                 59******************7788******886...899******99885 PP

  == domain 6  score: 0.2 bits;  conditional E-value: 0.33
                 EEEEEE--G CS
        RCC1   3 rVysWGrnd 11 
                 +Vy+WG n 
  EFC38276.1 533 NVYGWGINK 541
                 6*****876 PP

>> Trypsin  Trypsin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5   0.0   8.6e-26   3.1e-22       7     221 .]      29     259 ..      23     259 .. 0.80
   2 ?   -2.3   0.0      0.87   3.1e+03     105     131 ..     467     492 ..     456     524 .. 0.69

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 8.6e-26
                 TTTTSSTTEEEEEETTCEEEEEEEEEETTEEEEEGGGTTTGGGEEE.EESE.SBTTSCTTTEEEEEEEE.EEEETTEBTTTT..TTTEEEEEESSS..S CS
     Trypsin   7 aqkgsfpwqvslsvksgkhlCgGslisenwvlTAaHCvsnasdvkv.vlge.hnlkksegkeqklkvek.vivhpnynpstl..dnDiallklkep..v 98 
                  + ++ p++vsl++ +   lCgGs+++e+++lTAaHC+  a++ +  ++g+ +n+     +++k ++ +  +v p ++++ +    D+ ++ l +   +
  EFC38276.1  29 VN-EHIPFIVSLKIPN--DLCGGSILNERFILTAAHCFWFAKECEDiIVGAgSNILDAPLQQRKTPFHRdQYVPPTFDAKGKclFSDLRIVDLGAGneL 124
                 44.567********99..7*******************9944444446666666655555556666655545559999888567889999999877669 PP

                 TSBSSBHCCBBCSTTHTTSTTTEEEEEESSBSSTSS.BSSBEEEEEEEEEEHHHHHHH.TTTT.......STTTEEEEESTTSSSBCTTTTTTSEEEET CS
     Trypsin  99 klgdtvrpiclpaassslpvgttclvsGwgrtkekg.ksdtlqevevpvvsretcksa.ykgk.......vtenmlcagakeggkdacqGDSGGPlvcs 188
                  +  tv+p+ l ++++  +vg++++ +Gwg  +e++ +s++l +++  + + +tc  +    +        ++ ++ca    ++  +c+GDSG+P++  
  EFC38276.1 125 IFDGTVSPALLDTNGP--TVGASVTFAGWGIRNENSpHSQKLFKTTEIIQDYKTCPITdE--NflhctpnESSGQFCAWN--EKSISCPGDSGSPVFYV 217
                 9************777..*************99999999****9999999999**99750..245555567899999999..7899*********9877 PP

                 TT....EEEEEEEEE.....SSSSCTTSEEEEEEGGGGHHHH CS
     Trypsin 189 dg....elvGivswg.....kgcakgnrpgvytkvssyldwi 221
                  +    +++G+vs+      k c +++  +  t v++ ++wi
  EFC38276.1 218 ANdkskIVTGVVSATtayekKTCLQPGQKDLHTSVAKHTNWI 259
                 77779********66554568899999999999999999998 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.87
                 HCCBBCSTTHTTSTTTEEEEEESSBSS CS
     Trypsin 105 rpiclpaassslpvgttclvsGwgrtk 131
                   ic  + s s +v+++  v  wg+++
  EFC38276.1 467 ISICAGD-STSYEVTSKGHVYSWGYNE 492
                 4555555.3334666666666666643 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.1     0.051   1.8e+02      15      26 ..     263     274 ..     262     277 .. 0.81
   2 !    4.8   0.0    0.0069        25      10      27 ..     319     336 ..     317     339 .. 0.85
   3 !   16.8   0.4   1.2e-06    0.0045       4      24 ..     364     384 ..     361     385 .. 0.85
   4 !   17.1   0.0   9.9e-07    0.0035       1      29 [.     405     434 ..     405     435 .. 0.96
   5 !   17.4   0.2   7.9e-07    0.0028       1      27 [.     466     492 ..     466     494 .. 0.96
   6 ?    1.3   0.1     0.086   3.1e+02      18      28 ..     532     542 ..     525     544 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.051
      RCC1_2  15 tedGeVlcWGsN 26 
                 t+ +++++WG+ 
  EFC38276.1 263 TNQNTLYGWGRM 274
                 68899*****85 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0069
      RCC1_2  10 HscaLtedGeVlcWGsNs 27 
                 ++++++++++++ WG+ +
  EFC38276.1 319 FALGISASNRLYLWGRGN 336
                 799************965 PP

  == domain 3  score: 16.8 bits;  conditional E-value: 1.2e-06
      RCC1_2   4 vsaGdyHscaLtedGeVlcWG 24 
                  + G++Hs+aL++dG+V+ WG
  EFC38276.1 364 ACGGYSHSLALSTDGKVYEWG 384
                 45689*************998 PP

  == domain 4  score: 17.1 bits;  conditional E-value: 9.9e-07
      RCC1_2   1 VksvsaGdyHscaLted.GeVlcWGsNsdG 29 
                 +ks+s+G +H +a++ d  +++ WG N +G
  EFC38276.1 405 IKSISCGHSHNLAVSQDmKRLYFWGKNQYG 434
                 89***************999*********9 PP

  == domain 5  score: 17.4 bits;  conditional E-value: 7.9e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNs 27 
                 ++s++aGd+ s  +t+ G+V++WG N+
  EFC38276.1 466 IISICAGDSTSYEVTSKGHVYSWGYNE 492
                 79***********************96 PP

  == domain 6  score: 1.3 bits;  conditional E-value: 0.086
      RCC1_2  18 GeVlcWGsNsd 28 
                 ++V++WG N +
  EFC38276.1 532 NNVYGWGINKF 542
                 57*****9975 PP

>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   3.4e-05      0.12       3     141 ..      48     215 ..      46     228 .. 0.69
   2 ?   -2.6   0.0       2.7   9.5e+03      79     106 ..     478     507 ..     458     520 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3.4e-05
   Trypsin_2   3 GflvgsdglilTnaHvv...dsadgaav.......kaikkkveeagadgrevpakvvaadpel..DlAllkv....ssderaglpplplgpsealkgge 85 
                 G +++++  ilT+aH++   +++++  v       +a+ ++++ +++ ++ vp +  a+   l  Dl ++++    +   +  + p+ l++  +++g  
  EFC38276.1  48 GSILNERF-ILTAAHCFwfaKECEDIIVgagsnilDAPLQQRKTPFHRDQYVPPTFDAKGKCLfsDLRIVDLgagnELIFDGTVSPALLDTNGPTVGA- 144
                 66788888.********8874444444455555555666777777777777777777777544779******88866666677777778887777777. PP

   Trypsin_2  86 pvyvvGyplggeksgsvssGivsgvve...sesaasgegesfl...............qtdaatspGsSGGplf 141
                 +v+  G + ++e+  s +s ++ +++e   +++  ++++e+fl               + ++++ pG SG+p+f
  EFC38276.1 145 SVTFAGWGIRNEN--SPHSQKLFKTTEiiqDYKTCPITDENFLhctpnessgqfcawnEKSISC-PGDSGSPVF 215
                 *******888888..6666666666666774444555555555555555555456777666666.7******99 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.7
   Trypsin_2  79 ealkggepvyvvGyplggeksg...svssGi 106
                 e +++g  vy +Gy   +  ++   s++ Gi
  EFC38276.1 478 EVTSKG-HVYSWGYNEQSLLGTgisSICIGI 507
                 356667.899999954333333444555555 PP

>> DUF2694  Protein of unknown function (DUF2694)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00011      0.39      20      78 ..     362     418 ..     343     424 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00011
     DUF2694  20 rscrggylhsvalseaameadaerlaeaillaadvsylkallevrneivaaghspsaav 78 
                     ggy hs+als      +  +la+ai  +  v ++    ++++  +++ghs   av
  EFC38276.1 362 LDACGGYSHSLALSTDGKVYEWGTLADAIKKTPTVVVFPNNDKIKS--ISCGHSHNLAV 418
                 34569***************************99999988887765..78888876665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (669 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       514  (0.0286686); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.72u 0.27s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 3964.41
//
Query:       EFC38277.1  [L=504]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      5e-10   39.3   0.4      5e-10   39.3   0.4    3.3  3  DSPc           Dual specificity phosphatase, catalytic domain
    0.00048   19.8   0.6     0.0012   18.5   0.0    2.0  2  Y_phosphatase  Protein-tyrosine phosphatase


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   5.9       1.8   1.6e+04      13      63 ..     144     188 ..     112     192 .. 0.57
   2 !   39.3   0.4   5.5e-14     5e-10      41     115 ..     274     354 ..     236     373 .. 0.65
   3 ?   -3.3   2.7      0.83   7.5e+03      13      45 ..     412     444 ..     403     485 .. 0.51

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 1.8
                 HHHHHTCSEEEEESSSSSECECCTTTTSEEEEECCESSTTSCCGGGHHHHH CS
        DSPc  13 llsklgitlvinvtkevpnanalkkseieklripvedehetkiskyleeav 63 
                  +++++++ ++n     +     ++ ++++l+  +++++++ i++y+++++
  EFC38277.1 144 STNNNNLDNNLNNN--LN----NNNLDNNNLDNNLNNSSQNVIRNYFSNSK 188
                 33333333333322..22....23335555555556666666666666655 PP

  == domain 2  score: 39.3 bits;  conditional E-value: 5.5e-14
                 EEEEECCES....STTSCCGGGHHHHHHHHHHH..HHTT-EEEEEESSSSSHHHHHHHHHHHHHHTS.CHHHHHHHHHHHS.T CS
        DSPc  41 eklripved....ehetkiskyleeavefidka..kqkgkkvlVHCqaGisRSatliiaYlmktknl.slneayeflkerr.p 115
                 ++++  ++d     + + ++++++ +v+ id     +  k +l+HC++G++R++ +i+ Yl+k+k + ++++a+e++k  r  
  EFC38277.1 274 YYMN--IHDlnknLNVKLFTEQMDTIVNDIDLYisNNPTKYILIHCTHGLNRTGFVICYYLLKKKIIeNVEQAIEIFKIHRmT 354
                 2333..34442222333445566666666665544556689************************9999********998842 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 0.83
                 HHHHHTCSEEEEESSSSSECECCTTTTSEEEEE CS
        DSPc  13 llsklgitlvinvtkevpnanalkkseieklri 45 
                 + + ++i   in+ ++++n+ ++ ++++++ r 
  EFC38277.1 412 CFKHYHILKSINLLNKNDNKDDKDDKDRNDNRD 444
                 555566666666666666653323333333222 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.5      0.46   4.2e+03     105     105 ..     132     132 ..      90     190 .. 0.57
   2 !   18.5   0.0   1.3e-07    0.0012     167     214 ..     307     356 ..     257     360 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.46
                    E CS
  Y_phosphatase 105 l 105
                    +
     EFC38277.1 132 N 132
                    2 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 1.3e-07
                    STTSS-EEEECSSSSHHHHHHHHHHHHHHHHHH..HSEEEHHHHHHHHHT CS
  Y_phosphatase 167 eaksgpvvVhCsaGvgRtgtfvaldillqqlea..eeevdvlqivkelrk 214
                    ++ ++ +++hC +G +Rtg +++  +l +++ +  e+ +++++i ++ r+
     EFC38277.1 307 NNPTKYILIHCTHGLNRTGFVICYYLLKKKIIEnvEQAIEIFKIHRMTRT 356
                    5678889******************9999999944444999999888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (504 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2618  (0.14602); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        94  (0.0052429); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.87u 0.33s 00:00:01.20 Elapsed: 00:00:00.50
# Mc/sec: 3033.39
//
Query:       EFC38278.1  [L=506]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-24   86.7   3.4    2.4e-11   43.8   0.0    3.2  3  C2               C2 domain
     0.0011   18.7   0.1         56    3.7   0.0    4.3  4  Biotin_lipoyl_2  Biotin-lipoyl like
  ------ inclusion threshold ------
       0.18   12.1   5.3         12    6.3   0.0    3.3  3  FRD2             Bacteriophage FRD2 protein
       0.54   10.7   5.6        1.2    9.5   5.6    1.6  1  PRP1_N           PRP1 splicing factor, N-terminal
        3.6    6.9   7.4        5.5    6.3   7.4    1.2  1  DUF4820          Domain of unknown function (DUF4820)


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.8   0.0   6.8e-15   2.4e-11       4      90 ..      21     126 ..      18     141 .. 0.72
   2 ?   -1.3   0.3      0.76   2.7e+03      48      74 ..     327     354 ..     280     361 .. 0.74
   3 !   42.1   0.0   2.3e-14   8.3e-11      36      90 ..     387     442 ..     383     457 .. 0.89

  Alignments for each domain:
  == domain 1  score: 43.8 bits;  conditional E-value: 6.8e-15
                 EEEEEEEESSSSSST...........TSSCEEEEEEEE.......ECEEEEEE-SCSSSSSSEEEEEEEEEESC.HTTSEEEEEEEEECSSSTEEEEEE CS
          C2   4 evtvieAknLpnkdk...........kgssdpyvkvsl.......dgkqkakTrviknslnPvWnekftfevae.leeakLeveVfdndrlskddfiGk 83 
                  +++i++++L   d+            +s    v+vs              +T++  ++lnP+Wn +f+fe+ +   +  +++ V+d+drl+kdd +G 
  EFC38278.1  21 VIKIIRGEDLIIADAndfkqrlkdfkLSSFRHLVEVSNekvlpggLVGGFLRTTTQMKTLNPIWNDEFQFEILNeMDNLLIHFYVYDWDRLTKDDPMGD 119
                 56666666665554433344443333223455566666666655544456789989****************998889999****************** PP

                 EEEEGHH CS
          C2  84 veiplst 90 
                 v + l++
  EFC38278.1 120 VIFTLTK 126
                 ***9988 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.76
                 EEEEEEEE.EESCHTTSEEEEEEEEECS CS
          C2  48 vWnekftf.evaeleeakLeveVfdndr 74 
                 ++ +k+ + e++++ +++L +e ++nd 
  EFC38278.1 327 EFIQKYILnEIDDKMKKSLNFEMYNNDF 354
                 4556666656677888888888888875 PP

  == domain 3  score: 42.1 bits;  conditional E-value: 2.3e-14
                 EEE-SCSSSSSSEEEEEEEEEESC.HTTSEEEEEEEEECSSSTEEEEEEEEEEGHH CS
          C2  36 akTrviknslnPvWnekftfevae.leeakLeveVfdndrlskddfiGkveiplst 90 
                  +T++  ++lnP+Wn +f+fe+ +   +  +++ V+d+drl+kdd +G v + l++
  EFC38278.1 387 LRTTTQMKTLNPIWNDEFQFEILNeMDNLLIHFYVYDWDRLTKDDPMGDVIFTLTK 442
                 589999****************998889999*********************9988 PP

>> Biotin_lipoyl_2  Biotin-lipoyl like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.032   1.1e+02      27      38 ..     118     129 ..     117     133 .. 0.92
   2 ?    3.7   0.0     0.016        56      22      33 ..     144     155 ..     144     157 .. 0.92
   3 ?    2.7   0.0     0.032   1.1e+02      27      38 ..     434     445 ..     433     449 .. 0.92
   4 ?    3.7   0.0     0.016        56      22      33 ..     460     471 ..     460     473 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.032
  Biotin_lipoyl_2  27 GdvLaelDsral 38 
                      Gdv+++l +++l
       EFC38278.1 118 GDVIFTLTKEDL 129
                      9*******9987 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.016
  Biotin_lipoyl_2  22 qrVkaGdvLael 33 
                      q V++G++++e+
       EFC38278.1 144 QNVETGNIIFEI 155
                      89*********9 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.032
  Biotin_lipoyl_2  27 GdvLaelDsral 38 
                      Gdv+++l +++l
       EFC38278.1 434 GDVIFTLTKEDL 445
                      9*******9987 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.016
  Biotin_lipoyl_2  22 qrVkaGdvLael 33 
                      q V++G++++e+
       EFC38278.1 460 QNVETGNIIFEI 471
                      89*********9 PP

>> FRD2  Bacteriophage FRD2 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.0    0.0033        12      37      62 ..     111     140 ..      92     150 .. 0.82
   2 ?   -1.0   0.7       0.6   2.2e+03       5      56 ..     274     329 ..     271     353 .. 0.66
   3 ?    6.3   0.0    0.0033        12      37      62 ..     427     456 ..     408     466 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0033
        FRD2  37 iynddgmgddyfelseeefycf....reyk 62 
                 + +dd mgd  f l++e++y +    reyk
  EFC38278.1 111 LTKDDPMGDVIFTLTKEDLYFLvnkpREYK 140
                 668***************997633335555 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.6
        FRD2   5 iiqenggwfevksissldgfdyvteiicangeiyn....ddgmgddyfelseeefy 56 
                 i +en   + +++ +s d  +  t+    n +  n     +   ++ f+  eeef 
  EFC38278.1 274 INNENDNNLTINTTTSNDSNNNDTNNTTNNNDTNNsnnnSNSNSNNTFKKEEEEFI 329
                 56677777777777777777776666666655544110045566778888888884 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0033
        FRD2  37 iynddgmgddyfelseeefycf....reyk 62 
                 + +dd mgd  f l++e++y +    reyk
  EFC38278.1 427 LTKDDPMGDVIFTLTKEDLYFLvnkpREYK 456
                 668***************997633335555 PP

>> PRP1_N  PRP1 splicing factor, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   5.6   0.00033       1.2      39      93 ..     288     343 ..     249     371 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00033
                 ........-------------------.--------------------HHHHHHHH CS
      PRP1_N  39 keeeeeeeedeedlqdeendefegese.glfakaeydedDeeAdriyeeiderlde 93 
                 ++++++++++++ ++++++++ +++s+ +  ++ +++e++     i +eid+++++
  EFC38278.1 288 TSNDSNNNDTNNTTNNNDTNNSNNNSNsNSNNTFKKEEEEFIQKYILNEIDDKMKK 343
                 22222222222222222222222222213333336677777788999*******97 PP

>> DUF4820  Domain of unknown function (DUF4820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   7.4    0.0015       5.5     156     223 ..     265     339 ..     239     346 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0015
     DUF4820 156 p........vsseldnsartlterksekesaesseskkrnkeerdaeseeessedeeeeetvkellekyanensed 223
                 +        +++e dn+  t+++ +s+ +++++++++++n++ ++++++++s+++++ ++  +e ++ky  ++ +d
  EFC38278.1 265 NieqfhhisINNENDNN-LTINTTTSNDSNNNDTNNTTNNNDTNNSNNNSNSNSNNTFKKEEEEFIQKYILNEIDD 339
                 34455554477777774.444445565555555555566665666667777777777788889999***9887655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (506 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2194  (0.122372); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.82u 0.32s 00:00:01.13 Elapsed: 00:00:00.54
# Mc/sec: 2800.68
//
Query:       EFC38279.1  [L=646]
Description: hypothetical protein NAEGRDRAFT_81647 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0014   18.0   0.2       0.56    9.4   0.1    2.3  2  Rcd1      Cell differentiation family, Rcd1-like
  ------ inclusion threshold ------
       0.11   12.7   1.8         27    5.1   0.0    3.8  4  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
       0.15   12.5   0.4          1    9.9   0.2    2.7  2  TPR_17    Tetratricopeptide repeat
       0.21   12.2   8.3        4.1    8.1   3.8    2.6  2  Com_YlbF  Control of competence regulator ComK, YlbF/YmcA
          1    9.3   9.7        6.1    6.8   0.1    4.1  4  TPR_1     Tetratricopeptide repeat
        5.6    7.3  12.1        3.1    8.2   0.1    5.0  7  TPR_2     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Rcd1  Cell differentiation family, Rcd1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.0     0.002         6      87     178 ..     334     421 ..     326     424 .. 0.81
   2 !    9.4   0.1   0.00019      0.56     142     209 ..     558     618 ..     546     643 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.002
        Rcd1  87 lkakiplyLypfLnttsksrefEylRltsLgvigaLvktddkev.ikflldteivplclrimesGselsktvAtfIlqkiLlddeGLeYicqt 178
                 ++++ip+ L  f++  ++  +f+  R +s  ++   +ktd k++ i++l+       cl i+ s+++   +v  +  + i   +++L Y+ +t
  EFC38279.1 334 IETNIPIHLGNFIKALKVAAHFDGDRKQSIDILDECIKTDPKNIyIHYLKA-----SCLDILTSSETDLNVVHNNYSDAIHHLEKALAYLANT 421
                 689************************************999963677765.....4777777777777777666666666666666666655 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00019
        Rcd1 142 lclrimesGselsktvAtfIlqkiLlddeGLeYicqtaerfsavaevLnkmvvslteepssrllkhvi 209
                  cl+ m++  e     A  ++qkiL +d    Y+c++++ + +v + ++++ +s+   ++ +l +  i
  EFC38279.1 558 KCLEAMDFYMEKYDNDARLVFQKILCKD----YLCRSKDELRQVLKEFEQLKESI---QDLKLTNPYI 618
                 6**************************9....************99888887776...4555555555 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       3.7   1.1e+04       6      16 ..     258     268 ..     254     296 .. 0.69
   2 ?    5.1   0.0     0.009        27      37      66 ..     357     387 ..     354     392 .. 0.91
   3 ?    2.9   0.0     0.043   1.3e+02       2      22 ..     401     421 ..     400     431 .. 0.82
   4 ?    0.7   0.0      0.21   6.4e+02      18      46 ..     496     524 ..     484     532 .. 0.55

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.7
                 HHHHHHHHHHH CS
      ANAPC3   6 knAiflaerll 16 
                   A+fl++rl 
  EFC38279.1 258 AAALFLFNRLK 268
                 56888888876 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.009
                 T-HHHHHHHHHCT.SHHHC-HHHHHHHHHHH CS
      ANAPC3  37 gqykrAyellrka.klnskslgcrylfAqcl 66 
                 g+ k+ +++l+++ k+++k++ ++yl+A cl
  EFC38279.1 357 GDRKQSIDILDECiKTDPKNIYIHYLKASCL 387
                 6778899**********************97 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.043
                 TT-HHHHHHHHHHHH.HHH-- CS
      ANAPC3   2 qnnyknAiflaerllaaetes 22 
                 +nny +Ai ++e++la+ ++ 
  EFC38279.1 401 HNNYSDAIHHLEKALAYLANT 421
                 689999999999999876665 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.21
                 HHH--HHHHHHHHHHHHHTT-HHHHHHHH CS
      ANAPC3  18 aetespedayllAlclylngqykrAyell 46 
                 ++++ p+  + ++ c+y    y+ A + +
  EFC38279.1 496 RSPNGPYFYMIKGGCYYACDMYELAVNAY 524
                 44555555555555555555555555444 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       2.1   6.1e+03      13      23 ..     313     323 ..     301     348 .. 0.76
   2 ?    9.9   0.2   0.00033         1       3      24 ..     367     388 ..     365     420 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.1
      TPR_17  13 adaynnLAell 23 
                  +ay +L++++
  EFC38279.1 313 KNAYSYLGKTF 323
                 56777888775 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00033
      TPR_17   3 lkaleldPnnadaynnLAelll 24 
                  ++++ dP+n + ++++A +l 
  EFC38279.1 367 DECIKTDPKNIYIHYLKASCLD 388
                 79*****************997 PP

>> Com_YlbF  Control of competence regulator ComK, YlbF/YmcA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   3.8    0.0014       4.1      52      97 ..      74     119 ..      51     124 .. 0.69
   2 ?    5.6   0.1    0.0079        24      30      57 ..     590     617 ..     583     644 .. 0.66

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0014
                 HHTT----HHHHHHHH.HHHHHHHTSHHHHHHHHHHHHHHHHHHHHH CS
    Com_YlbF  52 qmkgeelkeeekkelq.elkeeldknplvkeyleaeqelnellqevn 97 
                 +m+  +lk++++++++ ++++e ++n+l+k+y+  e+++++l + + 
  EFC38279.1  74 KMFF-DLKKAKQQAAEkAVYSEQEQNELIKNYQVLEDKFKKLTENII 119
                 4444.555666655554788888888888888888888888887765 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0079
                 CSHHHHHHHHHHHHHHHHHHHHHHTT-- CS
    Com_YlbF  30 edeelqklikefkklqkelqekqmkgee 57 
                 + +el++ +kef++l++++q+ + + + 
  EFC38279.1 590 SKDELRQVLKEFEQLKESIQDLKLTNPY 617
                 5689999999999999999998877633 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.3       1.7   5.2e+03      16      27 ..     287     298 ..     286     299 .. 0.87
   2 ?   -1.3   0.0      0.76   2.3e+03      16      34 .]     358     376 ..     356     376 .. 0.82
   3 ?    6.8   0.1     0.002       6.1      15      29 ..     402     416 ..     401     417 .. 0.92
   4 ?    5.8   0.5    0.0044        13       4      25 ..     504     525 ..     501     527 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.7
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 +y+ A  +y  A
  EFC38279.1 287 DYEAAKLAYTTA 298
                 89***9999877 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.76
                 -HHHHHHHHHHHHHHSTTH CS
       TPR_1  16 kydeAleyyekALelnPnn 34 
                 + ++ ++  +++++ +P+n
  EFC38279.1 358 DRKQSIDILDECIKTDPKN 376
                 5567788899*******97 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.002
                 T-HHHHHHHHHHHHH CS
       TPR_1  15 gkydeAleyyekALe 29 
                 ++y +A+ + ekAL 
  EFC38279.1 402 NNYSDAIHHLEKALA 416
                 79***********95 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0044
                 HHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   4 lynlGnayfklgkydeAleyye 25 
                 +  +G +y+   +y+ A+ +y+
  EFC38279.1 504 YMIKGGCYYACDMYELAVNAYS 525
                 777999**************96 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.3       3.5     1e+04      16      27 ..     287     298 ..     287     298 .. 0.85
   2 ?   -1.6   0.0       1.4   4.1e+03      13      22 ..     341     350 ..     340     355 .. 0.85
   3 ?   -0.3   0.0      0.52   1.5e+03      15      34 .]     357     376 ..     352     376 .. 0.90
   4 ?    8.2   0.1     0.001       3.1      15      30 ..     402     417 ..     400     420 .. 0.90
   5 ?    3.2   0.1      0.04   1.2e+02       3      24 ..     503     524 ..     501     527 .. 0.87
   6 ?   -2.1   0.0         2   5.9e+03       4      24 ..     543     563 ..     541     564 .. 0.79
   7 ?   -2.4   0.0       2.4   7.2e+03      11      28 ..     565     582 ..     559     582 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.5
       TPR_2  16 dyeeAleafekA 27 
                 dye A+ a+  A
  EFC38279.1 287 DYEAAKLAYTTA 298
                 799999999876 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.4
       TPR_2  13 klgdyeeAle 22 
                 +lg++ +Al+
  EFC38279.1 341 HLGNFIKALK 350
                 799*****98 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.52
       TPR_2  15 gdyeeAleafekAleldPnn 34 
                 gd ++ ++ ++++++ dP+n
  EFC38279.1 357 GDRKQSIDILDECIKTDPKN 376
                 888999999*********97 PP

  == domain 4  score: 8.2 bits;  conditional E-value: 0.001
       TPR_2  15 gdyeeAleafekAlel 30 
                 ++y +A++++ekAl++
  EFC38279.1 402 NNYSDAIHHLEKALAY 417
                 79************86 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.04
       TPR_2   3 alynlGlayyklgdyeeAleaf 24 
                  ++  G +yy+ + ye A++a+
  EFC38279.1 503 FYMIKGGCYYACDMYELAVNAY 524
                 6777899*************99 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 2
       TPR_2   4 lynlGlayyklgdyeeAleaf 24 
                 l++ ++  ++lg  +++lea+
  EFC38279.1 543 LCYAANGMIALGYSDKCLEAM 563
                 677888889999999998875 PP

  == domain 7  score: -2.4 bits;  conditional E-value: 2.4
       TPR_2  11 yyklgdyeeAleafekAl 28 
                  y  +  ++A+  f+k l
  EFC38279.1 565 FYMEKYDNDARLVFQKIL 582
                 444444499999999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (646 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1377  (0.0768029); expected 358.6 (0.02)
Passed bias filter:                      693  (0.0386525); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.77u 0.34s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 3773.91
//
Query:       EFC38280.1  [L=1578]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-07   31.7   0.1     0.0014   19.2   0.0    4.6  3  Ank_4     Ankyrin repeats (many copies)
    8.7e-05   23.0   0.2       0.22   12.1   0.0    4.4  4  Ank_2     Ankyrin repeats (3 copies)
  ------ inclusion threshold ------
       0.02   15.4   0.0        1.2    9.9   0.0    3.9  3  Ank_3     Ankyrin repeat
       0.13   12.6   0.0          9    6.8   0.0    3.0  2  Ank_5     Ankyrin repeats (many copies)
       0.48   10.4   4.8       0.35   10.8   0.3    3.2  3  DUF1951   Domain of unknown function (DUF1951)


Domain annotation for each model (and alignments):
>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   3.9e-07    0.0014       2      42 ..     269     308 ..     268     317 .. 0.94
   2 ?   -2.6   0.0       2.5   9.1e+03      10      23 ..     511     527 ..     503     530 .. 0.68
   3 ?    4.8   0.0     0.012        43      12      49 ..    1070    1110 ..    1021    1116 .. 0.67

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 3.9e-07
       Ank_4   2 ltaLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiA 42 
                 +++Lh a+ ++++++v++Ll+ ga++  + + + +tal ++
  EFC38280.1 269 MPLLHFAVGKNNMKAVDSLLQLGASPSQR-DTNSNTALFYV 308
                 899**************************.999*****997 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.5
       Ank_4  10 i...sgrlelvrlLlek 23 
                 +   +g+++lv +L+e+
  EFC38280.1 511 QnmrAGNIPLVTFLVET 527
                 34448888999888875 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.012
       Ank_4   12 grlelvrlLlekgad...inaqdnrsGetalhiAakrgnve 49  
                  g+ +l+ +L++  ++   i a +++s et+lh  +++g ve
  EFC38280.1 1070 GCDKLLSSLICEFISmdqILAIKSDSNETPLHSICYGGCVE 1110
                  56666666665544455766667888888888877777555 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   6.1e-05      0.22       1      49 [.     272     325 ..     266     340 .. 0.78
   2 ?   -1.2   0.0      0.91   3.3e+03      25      48 ..     501     528 ..     471     553 .. 0.58
   3 ?   -1.1   0.0      0.81   2.9e+03      56      80 ..    1024    1048 ..     989    1055 .. 0.78
   4 ?    4.7   0.0     0.013        47      18      43 ..    1091    1113 ..    1025    1132 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 6.1e-05
       Ank_2   1 LhlAakngnlelvklLl.egadpn..k.ngktaLhyAakngnleivklLleh....a 49 
                 Lh+A+ ++n ++v+ Ll  ga p+  + n +taL+y ++    e++k L eh    +
  EFC38280.1 272 LHFAVGKNNMKAVDSLLqLGASPSqrDtNSNTALFYVTSL---EMLKKLAEHidieT 325
                 8999998878899999988888875436889999999997...89999999866542 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.91
       Ank_2  25 ngktaLhyAakn...gnleivklLle.h 48 
                   ++aL + ++n   gn+ +v +L+e h
  EFC38280.1 501 SSRSALSTIIQNmraGNIPLVTFLVEtH 528
                 4456666666643335555577777632 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.81
       Ank_2   56 pLhyAarsghleivklLlekgadin 80  
                   L +A++ g+ ++ k L+ +  ++n
  EFC38280.1 1024 LLKNAISVGNVKCTKRLISSFMNKN 1048
                  4667776677777777775544444 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.013
       Ank_2   18 egadpnkngktaLhyAakngnleivk 43  
                   ++d    ++t+Lh  + +g++e  +
  EFC38280.1 1091 IKSD---SNETPLHSICYGGCVESFQ 1113
                  1222...3467777777777665544 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00033       1.2       2      29 ..     268     294 ..     267     296 .. 0.92
   2 ?   -2.4   0.0       3.5   1.2e+04      11      26 ..     514     529 ..     513     532 .. 0.82
   3 ?   -0.1   0.0       0.6   2.2e+03       2      15 ..    1096    1109 ..    1095    1115 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00033
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                 G+ +Lh+A+  +n + v+ Ll+  ga +
  EFC38280.1 268 GMPLLHFAVGKNNMKAVDSLLQ-LGASP 294
                 889*******************.99987 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3.5
       Ank_3  11 rsgnleivkfLlenkg 26 
                 r+gn+++v fL+e ++
  EFC38280.1 514 RAGNIPLVTFLVETHN 529
                 8999********9655 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.6
       Ank_3    2 GetpLhlAarsgnl 15  
                  +etpLh  +  g++
  EFC38280.1 1096 NETPLHSICYGGCV 1109
                  69****99988776 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0    0.0025         9      19      53 ..     271     305 ..     268     308 .. 0.94
   2 ?    2.1   0.0     0.071   2.5e+02      16      36 ..    1096    1116 ..    1086    1122 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0025
       Ank_5  19 pLhvAakygaadvvrlLlargadlnltdsrGltal 53 
                  Lh+A+ +++   v  Ll  ga++ ++d + +tal
  EFC38280.1 271 LLHFAVGKNNMKAVDSLLQLGASPSQRDTNSNTAL 305
                 59***************************99**98 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.071
       Ank_5   16 gntpLhvAakygaadvvrlLl 36  
                   +tpLh  +++g+ + ++l +
  EFC38280.1 1096 NETPLHSICYGGCVESFQLVH 1116
                  34************9998876 PP

>> DUF1951  Domain of unknown function (DUF1951)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0         1   3.7e+03      57     100 ..     234     274 ..     225     285 .. 0.70
   2 ?   10.8   0.3   9.8e-05      0.35      49     119 ..     888     957 ..     866     959 .. 0.79
   3 ?   -3.7   0.1       3.2   1.1e+04      44      69 ..    1535    1560 ..    1531    1569 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1
     DUF1951  57 rnffintellkltaieeikdvlslfkknkevlikfclsyllykf 100
                 +n++  te   + +iee +++ s fk    +    c+   l +f
  EFC38280.1 234 KNLMQHTENALI-SIEENHTIPSDFKG--SIYMNTCMGMPLLHF 274
                 477777887767.89999999999985..466666666666655 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 9.8e-05
     DUF1951  49 neetkhyarnffintellkltaieeikdvlslfkknkevlikfclsyllykfsflfdeskkfklkkileav 119
                 n+++     +++i++e+lk   +       s+f+ +  +l+kf  +y l+k ++  ++  k  l+  +++v
  EFC38280.1 888 NDKDFWMREQVLIEAEILKA-CLGLSTPDFSKFQDHSSILEKFAKYYRLHKKNLSIEQYMKEFLTAEFKNV 957
                 55555445567788888887.4443344689***************************9999999999887 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 3.2
     DUF1951   44 ielikneetkhyarnffintellklt 69  
                  + +++n +++ +  n+  nt  +kl+
  EFC38280.1 1535 LSIVMNAKQQDFHSNINENTLEIKLS 1560
                  57888999999999999998888874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1578 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1926  (0.107424); expected 358.6 (0.02)
Passed bias filter:                      658  (0.0367003); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.15u 0.33s 00:00:01.48 Elapsed: 00:00:00.50
# Mc/sec: 9474.86
//
Query:       EFC38281.1  [L=629]
Description: BRCA1 associated protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      3e-33  114.0   1.8      4e-33  113.6   0.3    2.0  2  BRAP2            BRCA1-associated protein 2
      1e-19   70.6   7.5    3.2e-19   69.0   7.5    1.9  1  zf-UBP           Zn-finger in ubiquitin-hydrolases and other 
    2.3e-08   34.2   7.4    2.3e-08   34.2   7.4    2.4  2  zf-RING_2        Ring finger domain
    8.7e-07   28.7   7.3    2.4e-06   27.3   7.3    1.8  1  zf-C3HC4_2       Zinc finger, C3HC4 type (RING finger)
    1.4e-05   24.8   6.2    5.3e-05   23.0   6.2    2.1  1  zf-C3HC4         Zinc finger, C3HC4 type (RING finger)
    0.00033   20.3   3.9    0.00033   20.3   3.9    2.1  1  zf-RING_11       RING-like zinc finger
    0.00068   19.9  10.5     0.0031   17.8  10.5    2.3  1  zf-rbx1          RING-H2 zinc finger domain
  ------ inclusion threshold ------
      0.013   15.6  27.3      0.013   15.6  27.3    1.9  2  UPF0242          Uncharacterised protein family (UPF0242) N-t
       0.02   14.9   8.4      0.057   13.5   8.4    1.8  1  zf-ANAPC11       Anaphase-promoting complex subunit 11 RING-H
       0.11   12.6   9.6       0.18   11.8   6.5    2.5  2  zf-RING_UBOX     RING-type zinc-finger
       0.22   11.1   6.9       0.36   10.4   6.9    1.3  1  DUF885           Bacterial protein of unknown function (DUF88


Domain annotation for each model (and alignments):
>> BRAP2  BRCA1-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.6   0.3   2.4e-36     4e-33       3      96 ..     162     255 ..     160     258 .. 0.96
   2 ?   -2.9   0.1       5.2   8.5e+03      52      69 ..     457     474 ..     446     478 .. 0.79

  Alignments for each domain:
  == domain 1  score: 113.6 bits;  conditional E-value: 2.4e-36
       BRAP2   3 pvsrstllcilavPsylsladllkFvgsvlekvseiriirdgkenrymvLikfkdqesadeFykefngkkFssleeevChvvfvkevevtesae 96 
                 p++rs+l+ ilavPs +s+ad+++F++ +  +++++ri+rd+++n+ymvL++f++q++ad+F+ ++ng++F+sl++e+C++vfvk+ve+t++ +
  EFC38281.1 162 PEERSRLVSILAVPSFISIADFFEFIACFECNIEKTRILRDESPNKYMVLLQFDEQRNADSFFVQYNGRPFNSLDPEHCKIVFVKSVEFTSRPD 255
                 789**************************************************************************************99766 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 5.2
       BRAP2  52 LikfkdqesadeFykefn 69 
                 L++ + +++ d+F +e+n
  EFC38281.1 457 LLEAQYNSKLDSFLNEYN 474
                 677777888999999999 PP

>> zf-UBP  Zn-finger in ubiquitin-hydrolases and other protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.0   7.5     2e-22   3.2e-19       1      61 [.     370     429 ..     370     431 .. 0.96

  Alignments for each domain:
  == domain 1  score: 69.0 bits;  conditional E-value: 2e-22
                 -TTTH--.SSEEEETTT--EEE-TTTT-HHHHHHHHH---EEEETTT--EEETTTTEEBE- CS
      zf-UBP   1 CseCnsenknlWlCLkCghvgCgrksnghalkHyeetrHplavdlstlsvycyscddeved 61 
                 C eC+ e +nlW+CL+Cg vgCgr+++gha++H+ +t+H++a++ ++++v++y+ d +v++
  EFC38281.1 370 CGECGCE-SNLWICLTCGVVGCGRYEKGHAMEHFLQTNHTYAMEHNSQRVWDYTGDGYVHR 429
                 99***65.9*************************************************985 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.2   7.4   1.4e-11   2.3e-08       2      44 .]     318     359 ..     317     359 .. 0.85
   2 ?    1.2   6.0       0.3   4.9e+02       2      28 ..     354     377 ..     353     390 .. 0.67

  Alignments for each domain:
  == domain 1  score: 34.2 bits;  conditional E-value: 1.4e-11
   zf-RING_2   2 eCpICleelssads.vlllpCgHvfhreClerwlrssstCPlCr 44 
                 +Cp+Cl++l+s+ s ++++ C+H fh++Cl++w   +  CP+Cr
  EFC38281.1 318 TCPVCLDRLDSGASgIITTVCNHQFHCNCLTKWGDGN--CPVCR 359
                 7********99999633335*************8555..****9 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.3
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhre 28 
                 +Cp+C   + +++ ++ l+Cg + +++
  EFC38281.1 354 NCPVCR--Y-TEQITTELKCGECGCES 377
                 6****6..3.44666666788776654 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   7.3   1.5e-09   2.4e-06       2      40 .]     319     358 ..     318     358 .. 0.83

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 1.5e-09
  zf-C3HC4_2   2 CpiCldmlkdp...svvtpCgHvfCqkCilrsLeekneCPlC 40 
                 Cp+Cld+l  +   + +t C+H+f+ +C+ ++     +CP+C
  EFC38281.1 319 CPVCLDRLDSGasgIITTVCNHQFHCNCLTKW--GDGNCPVC 358
                 ********9752226788*************9..5559**** PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   6.2   3.2e-08   5.3e-05       1      41 []     319     358 ..     319     358 .. 0.96

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 3.2e-08
                 -TTT-S--SS-E....E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepn...elleCkHsfCskCirkilksrkkvkCPlC 41 
                 Cp+Cl+ +        ++ C+H+f+++C++k+ +     +CP+C
  EFC38281.1 319 CPVCLDRLDSGAsgiITTVCNHQFHCNCLTKWGD----GNCPVC 358
                 *********9999999******************....67***9 PP

>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   3.9     2e-07   0.00033       2      29 .]     319     347 ..     318     347 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 2e-07
  zf-RING_11   2 CsICLeefkpgq.alfilpCsHtFHfkCI 29 
                 C +CL+ +  g   ++++ C+H FH++C+
  EFC38281.1 319 CPVCLDRLDSGAsGIITTVCNHQFHCNCL 347
                 *********9993556666*********5 PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8  10.5   1.9e-06    0.0031      13      55 .]     318     359 ..     293     359 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.9e-06
     zf-rbx1  13 acieckapgdee.cpvvlGeCgHaFHlhCiskWlktrkvCPlcr 55 
                 +c+ c    d+    +++  C+H+FH +C++kW +   +CP+cr
  EFC38281.1 318 TCPVCLDRLDSGaSGIITTVCNHQFHCNCLTKWGD--GNCPVCR 359
                 56666666666666788889*************86..58****8 PP

>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   1.6       3.3   5.4e+03     123     143 ..      22      60 ..       4      69 .. 0.37
   2 ?   15.6  27.3   8.3e-06     0.013      67     183 ..     471     588 ..     441     593 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 3.3
     UPF0242 123 qekleaiae..................dfeelkleleeq 143
                 + k++++++                  d+++l++  +e+
  EFC38281.1  22 KNKKKEAVQsssasasssssttttqtlDINALSQSTKEE 60 
                 222222222000001111112222222444444444443 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 8.3e-06
     UPF0242  67 kskleekeaklteldeglktkeealeelqeee.eeLkeeldakeeelerlkeenqqLqekleaiaedfeelkleleeqLaekqellqeyqeti.eeqrs 163
                 +++++   ++lt+++  +++k   le+ ++++ e L +el+   ++ ++++++ q+ q+k+e+  ++  e+++el+++L + q++ +   e+  e+ ++
  EFC38281.1 471 NEYNQLLSQQLTSQRVYFENKLAGLEKDKDKQiESLINELQTYRQNTQKMTNKVQKTQKKAEK-EKEETEFLKELNKTLINNQKQYEIKIEKSeENYKK 568
                 344444456677777889999999998776653889999*************99999999998.66778999999999999999998766655056799 PP

     UPF0242 164 vlekrqdqieqLeskVrDln 183
                  lek++++i +Le +V+D++
  EFC38281.1 569 LLEKKDAKIRDLEEQVQDMM 588
                 *******************8 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   8.4   3.5e-05     0.057      34      82 ..     318     363 ..     312     389 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.5e-05
                 --TTCSTTTTT..S-EEEBTTS-EEEHHHHHHHHHHHSTSSB-TTTSSB-- CS
  zf-ANAPC11  34 tcpsckfpGdd..cplvlGkckhnfhlhcilkwletetskglcpmcrqtfk 82 
                 tcp c    d     ++   c+h+fh  c++kw       g+cp+cr t +
  EFC38281.1 318 TCPVCLDRLDSgaSGIITTVCNHQFHCNCLTKWG-----DGNCPVCRYTEQ 363
                 89999766554116799999*************5.....689*****8765 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   6.5   0.00011      0.18       1      32 [.     319     351 ..     319     370 .. 0.71
   2 ?    0.8   1.3      0.32   5.2e+02       1      17 [.     355     371 ..     355     380 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00011
  zf-RING_UBOX   1 CpIClelft.......dPlvlpCGHtFCreCl..welsksl 32 
                   Cp+Cl+ ++       +   + C H F+ +Cl  w     +
    EFC38281.1 319 CPVCLDRLDsgasgiiT---TVCNHQFHCNCLtkW-----G 351
                   ********987654322...35**********443.....2 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.32
  zf-RING_UBOX   1 CpICl..elftdPlvlpCG 17 
                   Cp+C+  e+ t+ l  +CG
    EFC38281.1 355 CPVCRytEQITTEL--KCG 371
                   ****9333444553..576 PP

>> DUF885  Bacterial protein of unknown function (DUF885)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   6.9   0.00022      0.36     168     327 ..     446     610 ..     398     626 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00022
                 ...HHHHHHHHHH.HHHHHHHHHHHHHHHHHCCHHHS-BSS..HHHHHHHHHHHHHS.SSS-HHHHHHHHHHHHHHHHHHHHHHHHHH.HH-....... CS
      DUF885 168 aekealraeleaalaeavkpayaeladfleeellpaarkdapdGeelYarllrsftt.tdltpeeihelglaelariraemeaiakev.gfk......g 258
                 ++ke   +e++++l+++    ++++ +  ++ l+++ + ++   + +++++l+     +d   e +     +el+  r++ ++++++v +++      +
  EFC38281.1 446 NQKE-AMREATELLEAQYNSKLDSFLNEYNQLLSQQLT-SQ---RVYFENKLAGLEKdKDKQIESLI----NELQTYRQNTQKMTNKVqKTQkkaekeK 535
                 3444.445666677888888888888888666666666.66...78999988876655555555554....4444444444444444422222333344 PP

                 HHHHHHHHHC.......H-GGGEEESHHHHHHHHHHHHHHHHHHHCCHHHCCT---TTS-GCCCEEEEEE-SS.-S CS
      DUF885 259 dlaevlaalr.......tdprfyleetdagreellaaaraaiaeldaklpehfgllpkaplevrrvpefiapsasg 327
                 +  e+l++l+       ++ +  +e+++++ ++ll++ +a+i +l+++++++ ++   ++ ++++ pe+ +++  +
  EFC38281.1 536 EETEFLKELNktlinnqKQYEIKIEKSEENYKKLLEKKDAKIRDLEEQVQDMMSHFS-TQDQIEKNPEMKNATIRA 610
                 7789999999999985555566789999**********************8886655.588888888888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (629 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4641  (0.258854); expected 358.6 (0.02)
Passed bias filter:                      797  (0.0444531); expected 358.6 (0.02)
Passed Vit filter:                       145  (0.00808746); expected 17.9 (0.001)
Passed Fwd filter:                        43  (0.00239835); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 1.16u 0.38s 00:00:01.54 Elapsed: 00:00:00.58
# Mc/sec: 3284.84
//
Query:       EFC38282.1  [L=913]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      3e-96  322.7   3.1      4e-96  322.3   3.1    1.2  1  Hepar_II_III_N  Heparinase II/III N-terminus
    1.3e-22   80.6   0.0    2.2e-22   79.9   0.0    1.3  1  Hepar_II_III    Heparinase II/III-like protein
     0.0093   16.3   9.3     0.0093   16.3   9.3    1.9  2  EGF_2           EGF-like domain


Domain annotation for each model (and alignments):
>> Hepar_II_III_N  Heparinase II/III N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  322.3   3.1  6.7e-100     4e-96       1     341 []      73     425 ..      73     425 .. 0.92

  Alignments for each domain:
  == domain 1  score: 322.3 bits;  conditional E-value: 6.7e-100
                     HHCCB-TTSTTTHHHHHHHHCT-HHHHHHHHHHHHH.HHHCCS.........-TT-TTSSS---HHHHHHHHHCCTTEE-BTTCSTB-EEETTCC CS
  Hepar_II_III_N   1 lFealnldypgLekVkaaveagdlekAakaLleYyr.ertnvt.........npdlelanvtiskaeqkiadealehtFyvnkgyqvsyskgkdi 85 
                     +F+aln+++p+L++Vk+av+++d++kA++a+++Y++ er+nv          +       + i+++   +a e l+ + +v +    ++   ++i
      EFC38282.1  73 FFNALNFSIPQLSSVKQAVQDKDYSKAKSAFCTYLKfERNNVPwsfnprkisS-------AGIASSYITKAKETLSGKITVVSI-PYTFADPENI 159
                     69**********************************88888887653333220.......334444455555556555555542.334446679* PP

                     -TT--STT........-CHHHHHHTTTTCHHHHHHH.HHHH--CHHHHH......HHHHHHHHHHHS-HHHHSSS..CCCT-HHHHHHHHHHH.H CS
  Hepar_II_III_N  86 dWeynptk.......adnElrwQlhRhkwweplaka.Yratgdekyake......wveqykdwikknPkeneaekkeksaWrtlevseRlqdq.v 165
                     +W+ynpt+       +d+E++wQl+R+++w++l++a ++a+g++++  +      +++q+++w+ ++P+++ a+++  saWrt+e+++Rl+++ +
      EFC38282.1 160 NWNYNPTAqpgspdpYDAEWTWQLNRMSFWTDLGRAlWYANGTSQMELAqnitnlFAAQLNSWVISQPRPTFANQAGYSAWRTIEAGIRLSTSwA 254
                     ************************************9*******9998888999***************************************9* PP

                     HHHHHHTTSTTS-HHHHHHHHHHHHHHHHHHHCCSTTSCCCHHHHHHHHHHHHHH-TTBTTHHHHHHHHHHHHHHHHHHCB-TTS-BTT--HHHH CS
  Hepar_II_III_N 166 eafelflnsksftpefLstflvsyaehaeyllknYseegNillfeaqalvtaGvlfPEfkeaekWresgisilneeikkqvleDGvqyeldlgYH 260
                     e++++fl++  + +++L+t+++s++e+a yl++ Y+++gN+l++e+++l+taG++fPEfk +++Wr+ +is++++e  +q+l+DG+qyel++gYH
      EFC38282.1 255 EIYHRFLTV--LPCDDLHTLVKSIYEQAIYLHT-YRTTGNWLTMECNGLFTAGAVFPEFKLSSTWRSIAISTMYNESVAQFLSDGAQYELSTGYH 346
                     *******99..**********************.************************************************************* PP

                     HHHHHHHHHHHHHHHCTT-GGGS-CCCCCCHHHHHHHHHHTS-CCC-S--.-SS-----HHHHHHHHHHHHHHSTT-HHHHH CS
  Hepar_II_III_N 261 iaaidnflkllrlakanglenelpasyvetlekaievvlnllyPdytlpa.fnDsksktksvllknlkeylelFPdneelky 341
                     +++idn++ l+ +ak++g+ ne+p +yv++l+ka+e+++++++P+ ++p  +nD+++++   +++++++y+++FPd++ +k+
      EFC38282.1 347 HVSIDNIIGLYLTAKTVGIVNEFPVDYVNRLQKALEFDISIMTPSLYMPGpLNDGWDYQ---VYNYITTYASYFPDSALIKW 425
                     *************************************************99********...******************99 PP

>> Hepar_II_III  Heparinase II/III-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.9   0.0   3.6e-26   2.2e-22       5     174 ..     438     622 ..     434     666 .. 0.81

  Alignments for each domain:
  == domain 1  score: 79.9 bits;  conditional E-value: 3.6e-26
                   SSEEETTTTEEEEES....T-EEEEEEEECTCTTB.CTTS-S-TTEEEEE.ETTEESS---C-SSTTTHHHHHHHTSGGGSSSEEETTBS--HCCC. CS
  Hepar_II_III   5 dskafpdsGyavlra....gatvlvvdagppgpgdlsghaHaDtLsfels.sggqrlivdcGtytyggpewrnaarstaaHNTlvvdgksssrfag. 95 
                   +s +++d G++v+r+     + + ++d +p g    +gh H+D+L++++   g++rl+ d G + y+ + +r++a st++HNT++vdg s+ r+ + 
    EFC38282.1 438 NSTLLKDCGFMVMRSgwssSDNYALMDISPLG----YGHEHQDKLNVIIDpYGRRRLLFDNGGGEYEQSIYRTFATSTESHNTVMVDGFSQKRVNRv 530
                   68899************9767***********....*************7367789************************************55554 PP

                   .HHSCCEEE.........EEEEEEESSSEEEEEEEEEEET.TTTEEEEEEEEEETT......TEEEEEEEEECSEEEE.EEEEEEEESTTECEEEE CS
  Hepar_II_III  96 .kfrlgrra.........evereeeeggvellaaehdgyaapfgvvhrRtllsldg......eslrveDslegsgehe.pfalrfhlhpdvevslg 174
                    ++++g++          +++  + + gv+++a ++  y   f+  h+R++l++++      +  + +D+l+++++ + +++ r+hl    +v+ +
    EFC38282.1 531 aNDLTGYGKketplpvfeTTQLIDYARGVYIDAYRNTSY---FPANHTREFLFVKPthnlgiNMYVAIDTLKSADGNPhHYQARWHL-RTTNVKFD 622
                   455555555667666553333334499999998899999...**********6666556677888999*******999*********.44444444 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.4      0.56   3.3e+03      23      32 .]     770     780 ..     769     780 .. 0.85
   2 !   16.3   9.3   1.6e-06    0.0093       4      32 .]     792     820 ..     790     820 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.56
       EGF_2  23 C.dsgyqGktC 32 
                 C  sgy+G  C
  EFC38282.1 770 CpTSGYSGVEC 780
                 77799***999 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 1.6e-06
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+g+G C ++  qC C +g++G +C
  EFC38282.1 792 NsSSVCSGNGNCTKPD-QCTCLNGFTGLNC 820
                 55789********999.**********999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (913 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       588  (0.032796); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.82u 0.39s 00:00:01.21 Elapsed: 00:00:00.56
# Mc/sec: 4880.15
//
Query:       EFC38283.1  [L=235]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.047   13.7   3.4       0.17   11.8   0.2    2.2  2  DUF4446          Protein of unknown function (DUF4446)
      0.081   13.8   3.9        1.5    9.8   1.3    2.4  2  EphA2_TM         Ephrin type-A receptor 2 transmembrane domai
      0.082   13.1   5.9       0.23   11.7   3.5    2.2  2  Shisa            Wnt and FGF inhibitory regulator
       0.11   13.2   3.9       0.85   10.3   0.2    2.5  2  DUF3139          Protein of unknown function (DUF3139)
        0.2   11.5   4.0        2.9    7.7   1.1    2.2  2  GAPT             GRB2-binding adapter (GAPT)
       0.55   10.9   2.1        7.7    7.2   0.0    2.5  2  OAD_gamma        Oxaloacetate decarboxylase, gamma chain


Domain annotation for each model (and alignments):
>> DUF4446  Protein of unknown function (DUF4446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   5.8e-05      0.17       4      64 ..       4      66 ..       1      73 [. 0.75
   2 ?    2.3   0.3     0.049   1.5e+02       4      27 ..     204     227 ..     199     234 .. 0.45

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.8e-05
     DUF4446  4 lvlavlvvillilli..vllvklkklkkkykklmkgkdgksleellkekleeveelkeeseel 64
                +vl++lv+i+ +l+   ++ ++   l +++k+++ +++++  e+ l+e+++++ e k++ ++l
  EFC38283.1  4 VVLLILVIIVGVLTHlsTQQISSLPLAQSIKQMIDHSHQHYPESDLSEYMKKLSETKQQRSAL 66
                45555555555555400455555567999****************************998775 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.049
     DUF4446   4 lvlavlvvillillivllvklkkl 27 
                 +++++l++ ++i++iv++++ ++ 
  EFC38283.1 204 VLFCLLILCCCICCIVCITRRNSR 227
                 233334444444555555444444 PP

>> EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.025        75      10      29 ..       4      23 ..       1      68 [. 0.50
   2 ?    9.8   1.3    0.0005       1.5       2      30 ..     200     228 ..     195     233 .. 0.51

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.025
    EphA2_TM 10 vllvilvilvlvlvrrrskn 29
                v+l+ilvi+v vl++ ++++
  EFC38283.1  4 VVLLILVIIVGVLTHLSTQQ 23
                34444444444443222222 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.0005
    EphA2_TM   2 iaaavaglvllvilvilvlvlvrrrsknr 30 
                 i+++v+ ++l+++  i+++v++ rr++++
  EFC38283.1 200 IIGVVLFCLLILCCCICCIVCITRRNSRQ 228
                 33334444444444556666665555443 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.09   2.7e+02      99     132 ..       4      40 ..       2      76 .. 0.51
   2 ?   11.7   3.5   7.8e-05      0.23      82     119 ..     195     229 ..     160     235 .] 0.68

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.09
       Shisa  99 vgvvvivcccgclkkkqrekr...pgrenlssalaev 132
                 v+ +++v+ +g+l+ +++++    p  ++++++  ++
  EFC38283.1   4 VVLLILVIIVGVLTHLSTQQIsslPLAQSIKQMIDHS 40 
                 4567777778888888877763334444444444333 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 7.8e-05
       Shisa  82 iyvpvlivktifivfvivgvvvivcccgclkkkqrekr 119
                 +++ ++i++ +f +++++   +++cc+ c++  +++++
  EFC38283.1 195 VTAGLIIGVVLFCLLILC---CCICCIVCITRRNSRQP 229
                 667778888888888777...88888888777776665 PP

>> DUF3139  Protein of unknown function (DUF3139)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.2   0.00029      0.85       6      61 ..       5      57 ..       1      65 [. 0.61
   2 ?    3.6   0.5     0.035   1.1e+02       4      25 ..     201     221 ..     199     232 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00029
     DUF3139  6 iililliillvivkvflglvgskpikkylankkldkyl..qekgykeddIksikpkyd 61
                ++lil+ii+ v  +        ++i +    + +++ +  + ++y+e+d ++  +k +
  EFC38283.1  5 VLLILVIIVGVL-T----HLSTQQISSLPLAQSIKQMIdhSHQHYPESDLSEYMKKLS 57
                333333333333.3....444455544444589999999999********99655554 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.035
     DUF3139   4 iiiililliillvivkvflglv 25 
                 i ++l++l+il+  ++ ++ ++
  EFC38283.1 201 IGVVLFCLLILCCCICCIV-CI 221
                 6789999999999999888.33 PP

>> GAPT  GRB2-binding adapter (GAPT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1    0.0098        29      19      90 ..       5      71 ..       1      75 [. 0.59
   2 ?    7.7   1.1   0.00098       2.9      10      39 ..     197     227 ..     190     233 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0098
        GAPT 19 llllvlcgiGcvwhwkhrestrftLPkflqrrssrkkdvtktlslsaevisakhkisvqtkdkksavkktdi 90
                +ll+++  +G++ h   ++++++ L + +++  ++ ++      ls       +k   +tk+++sa+  +di
  EFC38283.1  5 VLLILVIIVGVLTHLSTQQISSLPLAQSIKQMIDHSHQHYPESDLS-----EYMKKLSETKQQRSALATSDI 71
                3455555689999999999999998888877655544332222222.....223333456666666666665 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00098
        GAPT  10 vavaigvsLll.llvlcgiGcvwhwkhrest 39 
                 +++ igv L+  l++ c i c+    +r+s+
  EFC38283.1 197 AGLIIGVVLFClLILCCCICCIVCITRRNSR 227
                 567899***9834555678888888888776 PP

>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.6     0.075   2.3e+02      13      27 ..       4      18 ..       1      32 [. 0.69
   2 ?    7.2   0.0    0.0026       7.7       7      37 ..     197     227 ..     192     231 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.075
   OAD_gamma 13 vVFvvLilLslvisl 27
                vV+++L++++ v++ 
  EFC38283.1  4 VVLLILVIIVGVLTH 18
                566666666666554 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0026
   OAD_gamma   7 tllGmgvVFvvLilLslvislfskiikkkak 37 
                 + l +gvV+++L++L+ +i ++  i ++ + 
  EFC38283.1 197 AGLIIGVVLFCLLILCCCICCIVCITRRNSR 227
                 55668**************999888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1388  (0.0774165); expected 358.6 (0.02)
Passed bias filter:                      840  (0.0468515); expected 358.6 (0.02)
Passed Vit filter:                        99  (0.00552178); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.36s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 1381.99
//
Query:       EFC38284.1  [L=925]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.2e-39  129.9   2.6    1.4e-05   24.9   0.2   10.2 10  NHL           NHL repeat
    1.3e-10   41.3   1.2     0.0039   16.8   0.0    7.0  7  SGL           SMP-30/Gluconolactonase/LRE-like region
    7.5e-07   29.3  10.8       0.26   11.5   0.0    7.1  9  Arylesterase  Arylesterase
    0.00021   21.7   0.9    0.00039   20.9   0.9    1.5  1  GPS           GPCR proteolysis site, GPS, motif
     0.0077   15.5   0.1         32    3.6   0.0    4.2  4  Lactonase     Lactonase, 7-bladed beta-propeller
  ------ inclusion threshold ------
        1.1    9.4   5.9       0.15   12.3   1.8    1.6  2  Shisa         Wnt and FGF inhibitory regulator
        1.4    9.3   3.4          4    7.9   3.4    1.8  1  TMEM210       TMEM210 family


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   9.7e-06     0.025       4      27 ..      59      83 ..      58      84 .. 0.94
   2 !   15.1   0.0   6.7e-06     0.017       2      27 ..     115     140 ..     115     141 .. 0.92
   3 ?    1.5   0.0      0.14   3.5e+02       3      23 ..     175     196 ..     174     199 .. 0.82
   4 !    9.7   0.1   0.00035      0.89      15      27 ..     297     309 ..     296     310 .. 0.92
   5 !   12.1   0.0   5.9e-05      0.15       3      19 ..     393     409 ..     393     413 .. 0.92
   6 ?   -1.9   0.0       1.7   4.3e+03       9      19 ..     456     465 ..     448     468 .. 0.74
   7 !   16.0   0.0   3.6e-06    0.0092       3      25 ..     488     509 ..     487     512 .. 0.93
   8 !   24.9   0.2   5.3e-09   1.4e-05       5      27 ..     545     567 ..     543     568 .. 0.94
   9 !   10.0   0.0   0.00028      0.71      14      27 ..     611     624 ..     597     625 .. 0.80
  10 !   13.3   0.0   2.6e-05     0.066       3      27 ..     656     681 ..     655     682 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 9.7e-06
                EEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL  4 PhGvavd.snGdiyVaDsenhrvqv 27
                P+ v vd ++G++yV+D+ n+r+++
  EFC38284.1 59 PTKVKVDrKTGNVYVSDRINSRIRK 83
                99*********************87 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 6.7e-06
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n+P  v ++s++diy aD+enhr+++
  EFC38284.1 115 NNPGKVELSSTNDIYFADTENHRIRK 140
                 67999999****************97 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.14
                 SEEEEEEE.TTTEEEEEECCCT CS
         NHL   3 yPhGvavd.snGdiyVaDsenh 23 
                 +P  v ++ +  ++y++D+  h
  EFC38284.1 175 FPKAVKLShDEKQLYITDTAAH 196
                 677888888999******9877 PP

  == domain 4  score: 9.7 bits;  conditional E-value: 0.00035
                 EEEEECCCTEEEE CS
         NHL  15 iyVaDsenhrvqv 27 
                 +y+aD++n+r++v
  EFC38284.1 297 LYIADTNNNRIRV 309
                 8**********98 PP

  == domain 5  score: 12.1 bits;  conditional E-value: 5.9e-05
                 SEEEEEEETTTEEEEEE CS
         NHL   3 yPhGvavdsnGdiyVaD 19 
                 +P+Gvav+++G+++++D
  EFC38284.1 393 QPRGVAVSPSGEVFISD 409
                 7***************9 PP

  == domain 6  score: -1.9 bits;  conditional E-value: 1.7
                 EETTTEEEEEE CS
         NHL   9 vdsnGdiyVaD 19 
                   s+G+++++D
  EFC38284.1 456 F-SSGELFISD 465
                 3.89******9 PP

  == domain 7  score: 16.0 bits;  conditional E-value: 3.6e-06
                 SEEEEEEETTTEEEEEECCCTEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrv 25 
                 +PhG+a++ nG iyVaD ++hrv
  EFC38284.1 488 RPHGIAIF-NGMIYVADPKTHRV 509
                 8*******.************99 PP

  == domain 8  score: 24.9 bits;  conditional E-value: 5.3e-09
                 EEEEEETTTEEEEEECCCTEEEE CS
         NHL   5 hGvavdsnGdiyVaDsenhrvqv 27 
                 +Gv+v++nG++++aD+ nhr+++
  EFC38284.1 545 SGVSVLPNGEVVIADTSNHRIRK 567
                 79*******************97 PP

  == domain 9  score: 10.0 bits;  conditional E-value: 0.00028
                 EEEEEECCCTEEEE CS
         NHL  14 diyVaDsenhrvqv 27 
                 +i++ D++nhr+++
  EFC38284.1 611 EIFIVDTNNHRIRK 624
                 79**********97 PP

  == domain 10  score: 13.3 bits;  conditional E-value: 2.6e-05
                 SEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvqv 27 
                  P+ ++++ ++G+i++aD+en rv++
  EFC38284.1 656 TPTTISISpTTGQIFIADYENRRVRK 681
                 6999*******************987 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   1.5e-06    0.0039      52     165 ..      69     205 ..      59     210 .. 0.67
   2 !    5.1   0.0    0.0058        15     115     154 ..     213     250 ..     204     260 .. 0.82
   3 ?   -0.9   0.0      0.38   9.8e+02     144     160 ..     293     309 ..     288     333 .. 0.86
   4 ?    1.2   0.0      0.09   2.3e+02     165     214 ..     375     422 ..     344     426 .. 0.78
   5 !    4.8   0.0    0.0073        19     187     216 ..     490     518 ..     471     527 .. 0.81
   6 ?    3.9   0.0     0.013        34     195     216 ..     497     518 ..     496     581 .. 0.68
   7 ?    1.7   0.0     0.064   1.6e+02     139     212 ..     603     684 ..     545     685 .. 0.63

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.5e-06
         SGL  52 grlvvasksglall..dlasgeletlade.....ee...dekpllrfNDgvv..dpdGrlwfGtmgdeeakgeev.galyrldpdgk..........le 127
                 g+++v  + + ++   d+++g+ +t+a +            ++ +  N g+v  ++ + ++f + ++++ ++    g+++ + + gk          + 
  EFC38284.1  69 GNVYVSDRINSRIRkiDINTGKATTIAGNgiigySGdgqLATQANINNPGKVelSSTNDIYFADTENHRIRKIFAnGTIITIAGCGKfgfdlnevspVP 167
                 666666655555555577777777777775544311444222333334444411577778888888887777644766666666655566666666688 PP

         SGL 128 rvlddltipNGlawspdgktlYlaDsltrkiwaydvda 165
                     ++++p ++ +s+d+k+lY++D+++++i +y++++
  EFC38284.1 168 ASEAKINFPKAVKLSHDEKQLYITDTAAHMIKSYSFET 205
                 88899*****************************9954 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0058
         SGL 115 galyrldpdgklervlddltipNGlawspdgktlYlaDsl 154
                 g+lyr+  ++++  +  ++  p Gl ++p++k lY++Ds 
  EFC38284.1 213 GSLYRVPVNNET--TTVGVESPMGLSINPETKELYFVDSI 250
                 888888888444..445899999***************97 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.38
         SGL 144 dgktlYlaDsltrkiwa 160
                 +++tlY+aD+ +++i +
  EFC38284.1 293 ETTTLYIADTNNNRIRV 309
                 56899999999999976 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.09
         SGL 165 aeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfdpdG 214
                  + ++l+n ++  + + +  +p G+av  +G+v++  +++++v+r+  dG
  EFC38284.1 375 GQPKYLGNNKLATESQLF--QPRGVAVSPSGEVFISDIAEDTVRRIGSDG 422
                 555666666655444444..499**********************99988 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.0073
         SGL 187 DGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                  G+a+  +G ++vA  ++++v+r+++dG+ 
  EFC38284.1 490 HGIAI-FNGMIYVADPKTHRVIRISQDGSS 518
                 55555.489******************975 PP

  == domain 6  score: 3.9 bits;  conditional E-value: 0.013
         SGL 195 GnvwvAvwgggkvvrfdpdGkl 216
                 G ++vA  ++++v+r+++dG+ 
  EFC38284.1 497 GMIYVADPKTHRVIRISQDGSS 518
                 6677777777777777777653 PP

  == domain 7  score: 1.7 bits;  conditional E-value: 0.064
         SGL 139 lawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge.......gepDGlavDa.eGnvwvAvwgggkvvrfdp 212
                 + +sp ++ ++++D+ +++i +++ d +  ++    v     +g+       ++p  + +   +G++++A +++ +v+++dp
  EFC38284.1 603 VEVSPISSEIFIVDTNNHRIRKINSDGKLVTIAGTGVASLNGDGQistfasiNTPTTISISPtTGQIFIADYENRRVRKLDP 684
                 4556666677777777777777777766666666665544444446666666557777777667777777777777777665 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.13   3.4e+02      53      78 ..      56      81 ..      47      88 .. 0.82
   2 ?   -0.9   0.0      0.77     2e+03      31      61 ..     120     150 ..     117     158 .. 0.74
   3 !    8.2   0.0    0.0011       2.8      51      81 ..     171     201 ..     158     205 .. 0.85
   4 !   11.5   0.0    0.0001      0.26      27      74 ..     203     250 ..     200     256 .. 0.90
   5 ?   -3.7   0.0       5.5   1.4e+04      64      78 ..     293     307 ..     284     310 .. 0.71
   6 ?   -1.1   0.0       0.9   2.3e+03      43      77 ..     381     414 ..     378     418 .. 0.75
   7 ?   -3.8   0.0       6.2   1.6e+04      66      78 ..     497     509 ..     487     512 .. 0.68
   8 ?    3.2   0.0     0.039        99      35      78 ..     579     622 ..     563     629 .. 0.87
   9 ?    4.3   0.0     0.018        45      47      75 ..     648     676 ..     631     683 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.13
  Arylesterase 53 lssanGInidadkkyiyvadilresi 78
                   +s++ +++d +   +yv+d ++  i
    EFC38284.1 56 SISPTKVKVDRKTGNVYVSDRINSRI 81
                  46899***************999888 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.77
  Arylesterase  31 lqlawtavvYyspsevkvvasglssanGIni 61 
                   ++l  t+ +Y+   e++   + +   + I+i
    EFC38284.1 120 VELSSTNDIYFADTENHRIRKIFANGTIITI 150
                   6778899999999999888776666666666 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0011
  Arylesterase  51 sglssanGInidadkkyiyvadilresihvm 81 
                   ++++++  ++++ d+k +y++d  ++ i  +
    EFC38284.1 171 AKINFPKAVKLSHDEKQLYITDTAAHMIKSY 201
                   56899*********************99665 PP

  == domain 4  score: 11.5 bits;  conditional E-value: 0.0001
  Arylesterase  27 lemslqlawtavvYyspsevkvvasglssanGInidadkkyiyvadil 74 
                   +e+ l+ + ++ +Y +p ++++   g++s+ G+ i+++ k +y  d++
    EFC38284.1 203 FETGLVSIIAGSLYRVPVNNETTTVGVESPMGLSINPETKELYFVDSI 250
                   677889999999******************************988876 PP

  == domain 5  score: -3.7 bits;  conditional E-value: 5.5
  Arylesterase  64 dkkyiyvadilresi 78 
                   +   +y+ad  ++ i
    EFC38284.1 293 ETTTLYIADTNNNRI 307
                   456799999988887 PP

  == domain 6  score: -1.1 bits;  conditional E-value: 0.9
  Arylesterase  43 psevkvvasglssanGInidadkkyiyvadilres 77 
                   +++     s+l  + G+ +++    ++++di ++ 
    EFC38284.1 381 GNNKLATESQLFQPRGVAVSPSGE-VFISDIAEDT 414
                   55555566788899******9875.8999987765 PP

  == domain 7  score: -3.8 bits;  conditional E-value: 6.2
  Arylesterase  66 kyiyvadilresi 78 
                    +iyvad   + +
    EFC38284.1 497 GMIYVADPKTHRV 509
                   5799999777665 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.039
  Arylesterase  35 wtavvYyspsevkvvasglssanGInidadkkyiyvadilresi 78 
                    t+v  ys++++    s+l+ +  + +++    i++ d  ++ i
    EFC38284.1 579 GTGVAGYSGENILATNSQLNLPIDVEVSPISSEIFIVDTNNHRI 622
                   467889********************************999988 PP

  == domain 9  score: 4.3 bits;  conditional E-value: 0.018
  Arylesterase  47 kvvasglssanGInidadkkyiyvadilr 75 
                   +   +++++++ I i++    i++ad  +
    EFC38284.1 648 ISTFASINTPTTISISPTTGQIFIADYEN 676
                   556678999****************9765 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.9   1.5e-07   0.00039       2      45 .]     818     865 ..     817     865 .. 0.77

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 1.5e-07
         GPS   2 sCvfWdeeneetgsWsteGCel.......tesdnknetvCsCnHLtsFAvL 45 
                 +C +    n+e+++W ++G e+        +++     +C+ +HLtsF+v+
  EFC38284.1 818 TCMYF---NTEFNEWKNDGVETvlvksnvDSNTLVFTMTCKTSHLTSFSVI 865
                 8****...6789********8888887642222334567**********96 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.013        32     221     276 ..      27      87 ..      18     101 .. 0.73
   2 ?    2.8   0.0     0.022        57     230     273 ..     160     203 ..     149     212 .. 0.79
   3 ?    1.8   0.0     0.045   1.2e+02      31      63 ..     224     261 ..     213     274 .. 0.80
   4 ?    0.4   0.0      0.12   3.2e+02      84     110 ..     653     679 ..     600     685 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.013
                 E-TTTEEEEEEEEESS-T.SS-S-.......--EEEEEE-TTSSEEEEEETSSTEEEEEEE-TT CS
   Lactonase 221 deatgaleelqtvstlpe.gftgk.......nsaaeIrlspdgkflyvSnRgadsiavfavdea 276
                   ++ +l  l ++st+++ gf+++        s+  +++ ++  ++yvS+R ++ i   ++  +
  EFC38284.1  27 A-QQQKLDPLYRISTIAGgGFDDNvnagqvsISPTKVKVDRKTGNVYVSDRINSRIRKIDI--N 87 
                 3.56789999999999995599995555444466666666777899******999987777..3 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.022
                 EEEEESS-TSS-S---EEEEEE-TTSSEEEEEETSSTEEEEEEE CS
   Lactonase 230 lqtvstlpegftgknsaaeIrlspdgkflyvSnRgadsiavfav 273
                 l++vs++p+  ++ n + +++ls+d+k ly+ +  a  i  ++ 
  EFC38284.1 160 LNEVSPVPASEAKINFPKAVKLSHDEKQLYITDTAAHMIKSYSF 203
                 67788888888888899999999999999998887777777766 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.045
                 EEEEESS---SEEE-TTSSEEEEEET.S.....TTTEE CS
   Lactonase  31 elvaelenPsyLalspdgktlYavnetg.....eeggv 63 
                 +++  +e+P  L ++p++k lY v+  g     ++g+v
  EFC38284.1 224 TTTVGVESPMGLSINPETKELYFVDSIGvkkinQNGTV 261
                 557799*******************9988877555554 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.12
                 SSS-EEEEEE-TTSSEEEEEETTTTEE CS
   Lactonase  84 egaspchlsvdedgkllavAnYsggsv 110
                 + + p+ +s++++   +++A+Y + +v
  EFC38284.1 653 SINTPTTISISPTTGQIFIADYENRRV 679
                 5678999**************987666 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.1       4.8   1.2e+04     136     166 ..     717     747 ..     706     767 .. 0.57
   2 ?   12.3   1.8     6e-05      0.15      81     116 ..     878     921 ..     842     924 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 4.8
       Shisa 136 vtettsattvvhsrysepqqssssssypgat 166
                 v e+t++ tv+  ++ ++q ++s+++ p++ 
  EFC38284.1 717 VFEKTDTITVTFPPNFNTQLNNSNQNTPTTD 747
                 4435555555555555555555555555443 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 6e-05
       Shisa  81 d........iyvpvlivktifivfvivgvvvivcccgclkkkqr 116
                 +        i++ v iv++++++ v+  +++ +cc+  lk k+ 
  EFC38284.1 878 SaglsneaiIAIVVSIVGSVLVIGVVSAIIITTCCVLKLKNKGA 921
                 112223466889999********************988887765 PP

>> TMEM210  TMEM210 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   3.4    0.0015         4       6      47 ..     878     921 ..     875     925 .] 0.83

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0015
     TMEM210   6 slGlsrealiallvvlaG..vsascfcalvivavGvlrakgetc 47 
                 s Gls ea+ia++v + G  +     +a++i +  vl+ k++ +
  EFC38284.1 878 SAGLSNEAIIAIVVSIVGsvLVIGVVSAIIITTCCVLKLKNKGA 921
                 88***********99888434567899**********9998866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (925 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.86u 0.38s 00:00:01.24 Elapsed: 00:00:00.55
# Mc/sec: 5059.39
//
Query:       EFC38285.1  [L=848]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-19   69.5  29.3    0.00022   20.9   0.0    9.2  8  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   1.4   0.00011         2       9      42 ..     150     183 ..     141     189 .. 0.88
   2 !    9.3   0.2   5.1e-05      0.91      16      35 ..     298     317 ..     278     329 .. 0.85
   3 !    5.1   0.0     0.001        18      19      37 ..     343     361 ..     334     371 .. 0.83
   4 !    9.8   0.0   3.5e-05      0.63      15      38 ..     497     520 ..     481     541 .. 0.87
   5 !    9.8   0.3   3.7e-05      0.66       1      38 [.     594     631 ..     594     647 .. 0.87
   6 !    7.6   1.0   0.00018       3.2       1      39 [.     670     707 ..     670     726 .. 0.81
   7 !   11.9   0.0   7.9e-06      0.14       1      49 []     727     777 ..     727     777 .. 0.93
   8 !   20.9   0.0   1.2e-08   0.00022       1      36 [.     779     814 ..     779     822 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00011
     DUF4116   9 vkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 ++++ ++l+ ++e+L ++++ +l++v qn ++++
  EFC38285.1 150 CRIHLKNLEDCPESLLKNIDKCLAIVIQNFKVYD 183
                 6667789**********************99886 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 5.1e-05
     DUF4116  16 lkylseeLknDkeivlkAvk 35 
                 +++l+e+Lk++k++v+  ++
  EFC38285.1 298 FQNLPEDLKSNKDFVIFFLN 317
                 789************96665 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.001
     DUF4116  19 lseeLknDkeivlkAvkqn 37 
                 l ++L +Dk+++++A   n
  EFC38285.1 343 LHPSLIQDKDVIMEAFLTN 361
                 578999********97555 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 3.5e-05
     DUF4116  15 alkylseeLknDkeivlkAvkqng 38 
                  +k+l  eL+ D e+++++v +++
  EFC38285.1 497 LYKHLHTELREDTELMKQIVPIYP 520
                 79****************996666 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 3.7e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 + E+++  +k +++ l+ +s+e++ + ei+  +v++ +
  EFC38285.1 594 NLEFAKRTLKAFPYQLQRFSKEIQDNNEICNIIVESGC 631
                 67***************************999998755 PP

  == domain 6  score: 7.6 bits;  conditional E-value: 0.00018
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 + E+ + av++++++l   se++++D+e vl  ++ +++
  EFC38285.1 670 NPELFKIAVRNFPKILVM-SEKFQKDREMVLYTIECCKY 707
                 578889999999997755.************99985544 PP

  == domain 7  score: 11.9 bits;  conditional E-value: 7.9e-06
     DUF4116   1 DrEivleavkkngs..alkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eiv  a+   +    +++l++++k +  ++++ + ++++++ +++++L+
  EFC38285.1 727 DEEIVERAIMETPTfvDINNLPPRFKLNSKLAKATLLKYPNSYVHFPDHLK 777
                 899*****887776699*******************************997 PP

  == domain 8  score: 20.9 bits;  conditional E-value: 1.2e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 D Ei+  av+ n ++l+ l++ Lk+++++ l A+ +
  EFC38285.1 779 DLEIAELAVRANANNLNELPKHLKQNRDFFLLAISR 814
                 89********************************94 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (848 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       941  (0.0524848); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.82u 0.35s 00:00:01.17 Elapsed: 00:00:00.54
# Mc/sec: 4704.92
//
Query:       EFC38286.1  [L=1310]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-16   60.0  17.7    1.9e-05   24.8   1.4    4.1  4  zf-C2H2      Zinc finger, C2H2 type
    6.7e-16   57.9  17.7    2.8e-06   27.5   0.1    4.6  4  zf-H2C2_2    Zinc-finger double domain
    7.9e-06   26.3  28.1     0.0045   17.7   1.2    4.3  4  zf-C2H2_4    C2H2-type zinc finger
    0.00017   21.9   0.1    0.00078   19.8   0.1    2.2  1  zf-C2HE      C2HE / C2H2 / C2HC zinc-binding finger
     0.0011   18.7   8.1        1.2    9.0   0.1    3.7  3  zf-H2C2_5    C2H2-type zinc-finger domain
  ------ inclusion threshold ------
      0.046   13.7   9.3        1.1    9.3   0.4    3.4  3  zf-C2H2_6    C2H2-type zinc finger
      0.067   13.0   2.7        5.7    6.8   0.1    2.9  2  zf-C2H2_11   zinc-finger C2H2-type
      0.071   13.5   3.5        2.3    8.7   0.1    3.6  3  zf-met       Zinc-finger of C2H2 type
        0.3   11.8   6.9      0.096   13.4   1.6    2.2  2  zf-TRAF      TRAF-type zinc finger
        9.5    6.4   6.0        1.2    9.3   0.8    2.2  2  Zn-ribbon_8  Zinc ribbon domain


Domain annotation for each model (and alignments):
>> zf-C2H2  Zinc finger, C2H2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       8.8   1.6e+04       7      14 ..     862     869 ..     862     869 .. 0.88
   2 !   20.9   0.2   1.9e-07   0.00034       1      23 []    1220    1242 ..    1220    1242 .. 0.98
   3 !   24.2   1.4   1.7e-08   3.1e-05       1      23 []    1248    1272 ..    1248    1272 .. 0.98
   4 !   24.8   1.4   1.1e-08   1.9e-05       1      23 []    1278    1303 ..    1278    1303 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 8.8
                 TEEESSHH CS
     zf-C2H2   7 gksFkrks 14 
                 gk+Fkr+s
  EFC38286.1 862 GKVFKRNS 869
                 79****87 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 1.9e-07
                  EEETTTTEEESSHHHHHHHHHCC CS
     zf-C2H2    1 ykCpdCgksFkrksnLkrHirtH 23  
                  y+C+ Cgk F +  nLkrH+r H
  EFC38286.1 1220 YVCDACGKEFAQFANLKRHLRLH 1242
                  99********************9 PP

  == domain 3  score: 24.2 bits;  conditional E-value: 1.7e-08
                  EEET..TTTEEESSHHHHHHHHHCC CS
     zf-C2H2    1 ykCp..dCgksFkrksnLkrHirtH 23  
                  y+C+  +C+k+F r+s+L++H+r+H
  EFC38286.1 1248 YTCTfeGCNKKFVRRSDLQTHMRIH 1272
                  9***********************9 PP

  == domain 4  score: 24.8 bits;  conditional E-value: 1.1e-08
                  EEET..TTTEEESSHHHHHHHHHC.C CS
     zf-C2H2    1 ykCp..dCgksFkrksnLkrHirt.H 23  
                  y+C+  +Cgk+F++ snL+rH r+ H
  EFC38286.1 1278 YVCNveGCGKTFTTCSNLRRHERSvH 1303
                  99*********************999 PP

>> zf-H2C2_2  Zinc-finger double domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.2    0.0052       9.3      12      25 ..    1217    1230 ..    1208    1231 .. 0.82
   2 !   25.7   1.8   5.6e-09     1e-05       1      26 []    1234    1261 ..    1234    1261 .. 0.92
   3 !   27.5   0.1   1.6e-09   2.8e-06       1      26 []    1264    1291 ..    1264    1291 .. 0.93
   4 !    7.2   0.7    0.0042       7.5       1      13 [.    1294    1307 ..    1294    1310 .] 0.83

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0052
   zf-H2C2_2   12 ekpyeCplCdkaFk 25  
                  + +y C++C+k F+
  EFC38286.1 1217 KGEYVCDACGKEFA 1230
                  457**********7 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 5.6e-09
   zf-H2C2_2    1 nLrrHirkHtgekpyeCp..lCdkaFkt 26  
                  nL+rH+r H g kpy+C    C+k+F++
  EFC38286.1 1234 NLKRHLRLHSGNKPYTCTfeGCNKKFVR 1261
                  8*****************755*****85 PP

  == domain 3  score: 27.5 bits;  conditional E-value: 1.6e-09
   zf-H2C2_2    1 nLrrHirkHtgekpyeCp..lCdkaFkt 26  
                  +L+ H+r Htge+py C    C+k+F+t
  EFC38286.1 1264 DLQTHMRIHTGERPYVCNveGCGKTFTT 1291
                  6999**************877*****97 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0042
   zf-H2C2_2    1 nLrrHirk.Htgek 13  
                  nLrrH r+ Ht+++
  EFC38286.1 1294 NLRRHERSvHTNPS 1307
                  8******55**886 PP

>> zf-C2H2_4  C2H2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -8.9   6.9        10   1.8e+04      17      24 .]      23      30 ..      17      30 .. 0.74
   2 !   14.9   0.3     2e-05     0.037       1      23 [.    1220    1242 ..    1220    1243 .. 0.95
   3 !   14.4   0.7   2.8e-05      0.05       1      23 [.    1248    1272 ..    1248    1273 .. 0.95
   4 !   17.7   1.2   2.5e-06    0.0045       1      24 []    1278    1303 ..    1278    1303 .. 0.94

  Alignments for each domain:
  == domain 1  score: -8.9 bits;  conditional E-value: 10
   zf-C2H2_4 17 lrHlkthH 24
                 +H ++hH
  EFC38286.1 23 HHHHNNHH 30
                46889999 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 2e-05
   zf-C2H2_4    1 fkCpiCgksFsskkaLlrHlkth 23  
                  + C+ Cgk F    +L+rHl+ h
  EFC38286.1 1220 YVCDACGKEFAQFANLKRHLRLH 1242
                  89*******************99 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 2.8e-05
   zf-C2H2_4    1 fkCpi..CgksFsskkaLlrHlkth 23  
                  ++C++  C+k F ++++L++H++ h
  EFC38286.1 1248 YTCTFegCNKKFVRRSDLQTHMRIH 1272
                  7899999****************99 PP

  == domain 4  score: 17.7 bits;  conditional E-value: 2.5e-06
   zf-C2H2_4    1 fkCpi..CgksFsskkaLlrHlkthH 24  
                  + C +  Cgk+F+++++L+rH +++H
  EFC38286.1 1278 YVCNVegCGKTFTTCSNLRRHERSVH 1303
                  7799999*****************99 PP

>> zf-C2HE  C2HE / C2H2 / C2HC zinc-binding finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.1   4.3e-07   0.00078      12      61 ..    1190    1242 ..    1178    1245 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 4.3e-07
     zf-C2HE   12 peelekdgei.....eslseeqskelilktpLkCtrCganfgnkfpkLKeHLeee 61  
                  ++el++d++      +   +e++++   k++  C  Cg +++ +f++LK+HL  +
  EFC38286.1 1190 LAELDDDDDDevglsKGVTKENATKN-SKGEYVCDACG-KEFAQFANLKRHLRLH 1242
                  34666666445566633445555556.89*********.*************877 PP

>> zf-H2C2_5  C2H2-type zinc-finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.1   0.00065       1.2      14      26 .]    1233    1244 ..    1230    1244 .. 0.91
   2 !    7.6   0.3    0.0018       3.3      12      26 .]    1261    1274 ..    1260    1274 .. 0.91
   3 ?    5.1   0.5     0.011        19      14      26 .]    1293    1305 ..    1290    1305 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00065
   zf-H2C2_5   14 snLkRHlrrkHtg 26  
                  +nLkRHlr  H+g
  EFC38286.1 1233 ANLKRHLR-LHSG 1244
                  7*******.**98 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0018
   zf-H2C2_5   12 wksnLkRHlrrkHtg 26  
                  ++s+L+ H+r +Htg
  EFC38286.1 1261 RRSDLQTHMR-IHTG 1274
                  689*******.***8 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.011
   zf-H2C2_5   14 snLkRHlrrkHtg 26  
                  snL+RH r +Ht+
  EFC38286.1 1293 SNLRRHERSVHTN 1305
                  9**********95 PP

>> zf-C2H2_6  C2H2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.4   0.00062       1.1       2      24 ..    1220    1242 ..    1220    1244 .. 0.92
   2 ?    1.0   0.1      0.24   4.4e+02       7      24 ..    1255    1272 ..    1254    1275 .. 0.91
   3 ?    6.8   0.8    0.0037       6.7       7      25 ..    1285    1303 ..    1278    1304 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00062
   zf-C2H2_6    2 heCsvCsksFpslqaLggHkksH 24  
                  ++C+ C+k+F  + +L  H++ H
  EFC38286.1 1220 YVCDACGKEFAQFANLKRHLRLH 1242
                  89**************9999877 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.24
   zf-C2H2_6    7 CsksFpslqaLggHkksH 24  
                  C+k F    +L +H++ H
  EFC38286.1 1255 CNKKFVRRSDLQTHMRIH 1272
                  ***************977 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0037
   zf-C2H2_6    7 CsksFpslqaLggHkksHr 25  
                  C+k+F +  +L+ H +s +
  EFC38286.1 1285 CGKTFTTCSNLRRHERSVH 1303
                  **************99965 PP

>> zf-C2H2_11  zinc-finger C2H2-type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.1    0.0032       5.7       7      25 ..    1222    1240 ..    1220    1242 .. 0.93
   2 ?    5.1   0.3     0.011        19      10      28 ..    1285    1303 ..    1283    1303 .. 0.95

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0032
  zf-C2H2_11    7 CleCGlcftSqlsLsRHlf 25  
                  C  CG  f+    L+RHl+
  EFC38286.1 1222 CDACGKEFAQFANLKRHLR 1240
                  999**************98 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.011
  zf-C2H2_11   10 CGlcftSqlsLsRHlfIvH 28  
                  CG  ft    L+RH + vH
  EFC38286.1 1285 CGKTFTTCSNLRRHERSVH 1303
                  **************99999 PP

>> zf-met  Zinc-finger of C2H2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1       0.1   1.8e+02       1      21 [.    1220    1240 ..    1220    1240 .. 0.87
   2 ?    8.7   0.1    0.0013       2.3       6      22 ..    1255    1271 ..    1253    1273 .. 0.92
   3 ?    0.6   0.1      0.48   8.6e+02       6      22 ..    1285    1301 ..    1283    1302 .. 0.93

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.1
      zf-met    1 fyCelCnvtfnsesqlksHlq 21  
                  + C++C + f   ++lk Hl+
  EFC38286.1 1220 YVCDACGKEFAQFANLKRHLR 1240
                  78********98888888886 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0013
      zf-met    6 CnvtfnsesqlksHlqG 22  
                  Cn++f  +s+l++H++ 
  EFC38286.1 1255 CNKKFVRRSDLQTHMRI 1271
                  ***************96 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.48
      zf-met    6 CnvtfnsesqlksHlqG 22  
                  C +tf+  s+l+ H ++
  EFC38286.1 1285 CGKTFTTCSNLRRHERS 1301
                  99************997 PP

>> zf-TRAF  TRAF-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   1.6   5.4e-05     0.096      11      60 .]    1221    1268 ..    1215    1268 .. 0.87
   2 ?    9.2   2.0    0.0011         2      15      60 .]    1254    1298 ..    1253    1298 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 5.4e-05
                  E-TT--S-BEEETTTCCCCCCTTSTTS--XXSSXXXXSXXXXX.HHHHHHT CS
     zf-TRAF   11 pCpnecckkkilRkdlkdHlekdCkkaevkCkfkevGCkekvk.realqkH 60  
                   C + c+k+  +  +lk Hl+    + + +C+f   GC++k+  r++lq H
  EFC38286.1 1221 VC-DACGKEFAQFANLKRHLRLHSGNKPYTCTF--EGCNKKFVrRSDLQTH 1268
                  68.78**999999********************..9**9997516789988 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0011
                  --S-BEEETTTCCCCCCTTSTTS--XXSSXXXXSXXXXXH.HHHHHT CS
     zf-TRAF   15 ecckkkilRkdlkdHlekdCkkaevkCkfkevGCkekvkr.ealqkH 60  
                  +c kk + R dl+ H++    +++  C+    GC +++ + ++l +H
  EFC38286.1 1254 GCNKKFVRRSDLQTHMRIHTGERPYVCNV--EGCGKTFTTcSNLRRH 1298
                  7999***********************99..9**9998753677776 PP

>> Zn-ribbon_8  Zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.8   0.00066       1.2       5      20 ..    1219    1234 ..    1219    1262 .. 0.84
   2 ?   -1.9   0.4       2.2   3.9e+03       6      17 ..    1278    1291 ..    1278    1301 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00066
  Zn-ribbon_8    5 eYrCeeCghefevlqs 20  
                   eY C++Cg+ef +++ 
   EFC38286.1 1219 EYVCDACGKEFAQFAN 1234
                   8**********97654 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 2.2
  Zn-ribbon_8    6 YrCee..Cghefev 17  
                   Y C+   Cg++f+ 
   EFC38286.1 1278 YVCNVegCGKTFTT 1291
                   7777667***9984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2447  (0.136483); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.20u 0.35s 00:00:01.54 Elapsed: 00:00:00.61
# Mc/sec: 6432.25
//
Query:       EFC38287.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.5e-09   36.1   0.0    9.8e-09   35.5   0.0    1.4  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    7.1e-08   32.4   0.1    1.1e-07   31.9   0.1    1.4  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    7.1e-06   26.4   0.0    1.1e-05   25.8   0.0    1.3  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
    8.9e-05   22.6   0.1    0.00014   21.9   0.1    1.6  1  Acetyltransf_9   Acetyltransferase (GNAT) domain
    9.4e-05   22.3   0.0    0.00016   21.5   0.0    1.4  1  FR47             FR47-like protein
  ------ inclusion threshold ------
      0.012   15.7   0.0      0.021   14.9   0.0    1.4  1  Acetyltransf_CG  GCN5-related N-acetyl-transferase
      0.027   14.1   0.0      0.049   13.2   0.0    1.5  1  GNAT_acetyltran  GNAT acetyltransferase
       0.16   11.4   0.3       0.22   10.9   0.3    1.1  1  PNMA             PNMA


Domain annotation for each model (and alignments):
>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.5   0.0   4.4e-12   9.8e-09      44     117 .]     126     192 ..      90     192 .. 0.85

  Alignments for each domain:
  == domain 1  score: 35.5 bits;  conditional E-value: 4.4e-12
                     EEEEEEEEEEETTSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHTTESEEEEEEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  44 liGfisllkipdekggvayieslaVspeyrgkGlGsaLlealeerareegikkivlaveedndaairlYeklGF 117
                     ++++  l +     ++va i+ la +  +r++G ++ L+  +++ a++ g++k+vl   e  +  i+ Yek+GF
      EFC38287.1 126 IVACGKLVMG----KHVASINHLATRDGHRNQGFATILMVSMIDMAKQLGYTKMVL---EATEMGIGIYEKFGF 192
                     4555544444....55*************************************9**...445555********9 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.9   0.1   4.7e-11   1.1e-07      42     109 ..     126     195 ..      84     202 .. 0.86

  Alignments for each domain:
  == domain 1  score: 31.9 bits;  conditional E-value: 4.7e-11
  Acetyltransf_10  42 ivGviel.rdgs..hisllfVdpeyrgqGigkaLleaveeeaekdgikleltvnaspyavpfYeklGFkav 109
                      iv +++l + ++   i +l+ ++ +r qG ++ L+  +++ a++ g+  ++ ++a+   +++Yek+GFk+v
       EFC38287.1 126 IVACGKLvMGKHvaSINHLATRDGHRNQGFATILMVSMIDMAKQLGYT-KMVLEATEMGIGIYEKFGFKPV 195
                      55455443333355899*************************999999.********************97 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.0   4.8e-09   1.1e-05       7      76 .]     127     194 ..     100     194 .. 0.70

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 4.8e-09
                     EEEETTEEEEEEEEEEESTCTEEEEE-GGGTTSSHHHHHHH.H...TT.SEEEEEEEEE.THHHHHHHHHHTTEEE CS
  Acetyltransf_7   7 VaeddgkivGfialslldaeitrlaVdpeyrgkGiGraLle.a...ae.kgiileqlel.naekaikfYeklGFee 76 
                     Va      +G +++  + a+i++la++  +r++G ++ L+  +   a+  g++ +   l ++e  i+ Yek+GF++
      EFC38287.1 127 VA------CGKLVMGKHVASINHLATRDGHRNQGFATILMVsMidmAKqLGYT-K-MVLeATEMGIGIYEKFGFKP 194
                     23......444444444489999*****************7334432245543.2.12222226799*******95 PP

>> Acetyltransf_9  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.1   6.4e-08   0.00014      73     127 ..     138     194 ..      65     195 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 6.4e-08
                     EEEEEEEEE-CCGTTS-HHHHHHHHHHHHHHHTT--EEEE--SSH..HHHHTTT-EE CS
  Acetyltransf_9  73 aagvtgVavapehrgrgvlskLlaraleemreegqplsllfPssi..piYrrfGyei 127
                     +a +   a+   hr++g+++ L+  +++ +++ g++  +l ++++  +iY++fG+++
      EFC38287.1 138 VASINHLATRDGHRNQGFATILMVSMIDMAKQLGYTKMVLEATEMgiGIYEKFGFKP 194
                     6778889***********************************8854499******87 PP

>> FR47  FR47-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.0   7.3e-08   0.00016      19      78 ..     136     193 ..     113     199 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 7.3e-08
                 -TTSSEEEEEE-GGG-SSSHHHHHHHHHHHHHHHS-S-EEEEEETT-HHHHHHHHHHT-E CS
        FR47  19 kdggelgalqvlpehrrrGlgsrlvkalakeiaergktvllvvvasNtpsirlyeklGfe 78 
                 k + ++  l +++ hr++G+++ l  +++    + g+t +++   + +  i +yek Gf+
  EFC38287.1 136 KHVASINHLATRDGHRNQGFATILMVSMIDMAKQLGYTKMVLE--ATEMGIGIYEKFGFK 193
                 5668999*******************************99875..55789*********7 PP

>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   0.0   9.4e-06     0.021      21      58 ..     135     172 ..     116     178 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 9.4e-06
  Acetyltransf_CG  21 kegvldfthTeVpeelrGkGiAkkLvkaalddareegl 58 
                      +++v  ++h  + + +r +G+A  L+ +++d a++ g+
       EFC38287.1 135 GKHVASINHLATRDGHRNQGFATILMVSMIDMAKQLGY 172
                      578999****************************9886 PP

>> GNAT_acetyltran  GNAT acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   2.2e-05     0.049     186     240 ..     144     198 ..     119     201 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.2e-05
  GNAT_acetyltran 186 idTkedyrrkgLAtivaaalileclkrglyPsWDaaneaSvaLaekLGYefekeY 240
                       +T+  +r++g+Ati+  ++i+ + + g++     a+e+ + ++ek+G++ + ++
       EFC38287.1 144 LATRDGHRNQGFATILMVSMIDMAKQLGYTKMVLEATEMGIGIYEKFGFKPVYDF 198
                      68************************999988877899***********987765 PP

>> PNMA  PNMA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.3   9.7e-05      0.22     143     201 ..      20      79 ..       4      82 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 9.7e-05
        PNMA 143 aealgqllgaalqpllealayrkLrvfsgaeipspgEesfesW.leraqemleawavvse 201
                 ++ l++  ++  + ++e+++y  + +fsg++i +++ +sfe   +++ +em++ w   s+
  EFC38287.1  20 IQDLTEYYQEKRRWMVENMEYSSIPIFSGRKICENEKKSFELVeMKSPEEMVQFWTCQSD 79 
                 5566677777777789*************************7438899999999996665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       681  (0.0379832); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.59u 0.36s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1146.86
//
Query:       EFC38288.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       438  (0.0244297); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1425.62
//
Query:       EFC38289.1  [L=326]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.2e-07   29.3   0.2    1.5e-06   28.2   0.2    1.6  1  Myb_DNA-binding  Myb-like DNA-binding domain


Domain annotation for each model (and alignments):
>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   0.2   8.6e-11   1.5e-06       2      30 ..     293     322 ..     292     326 .] 0.89

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 8.6e-11
                      SSSBHHHHHHHHHHHHHHT.TCHHHHHHHH CS
  Myb_DNA-binding   2 gkWteeEdelLleavkkhG.nrWkkIaerl 30 
                      g+Wt +E+e +++++++ G +rW++Iae++
       EFC38289.1 293 GSWTDQEHEDFVRGLNECGkGRWREIAEKY 322
                      89*************************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (326 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2059  (0.114842); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2008.49
//
Query:       EFC38290.1  [L=1763]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.2e-52  176.8   0.0    6.1e-52  175.9   0.0    1.5  1  Guanylate_cyc   Adenylate and Guanylate cyclase catalytic dom
    5.1e-15   55.6   0.2    1.4e-14   54.2   0.2    1.8  1  PAS_9           PAS domain
    4.8e-08   33.0   0.0    1.2e-07   31.7   0.0    1.7  1  PAS             PAS fold
  ------ inclusion threshold ------
      0.055   13.7   0.0       0.11   12.8   0.0    1.4  1  PAS_4           PAS fold
      0.098   13.3   0.2        1.4    9.5   0.0    2.8  2  PAS_10          PAS domain
       0.12   12.6   5.4       0.43   10.8   5.4    1.9  1  DUF3886         Protein of unknown function (DUF3886)
       0.17   11.3   0.0       0.17   11.3   0.0    1.9  2  HNOBA           Heme NO binding associated
        4.7    7.6   8.6         43    4.5   3.0    3.5  3  TSNAXIP1_N      Translin-associated factor X-interacting N-te


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  175.9   0.0   2.7e-55   6.1e-52       3     182 ..    1515    1699 ..    1513    1700 .. 0.97

  Alignments for each domain:
  == domain 1  score: 175.9 bits;  conditional E-value: 2.7e-55
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp..eekaahaaklaelaLdmlealeevav 94  
                     ae++++v+ +F+d+vgft+ls+  ++ e+v++Lne++  fd+l+d+++++k+ktiGd+y +v gl+  +++ +h ++++++++d ++ l+ ++ 
     EFC38290.1 1515 AEKFNDVSCFFSDMVGFTKLSTGIQASELVQMLNEIVIGFDDLTDKYNLEKIKTIGDSYFCVGGLHglNAQSDHPERILRFSIDTFDVLQRFNS 1608
                     68899**************************************************************99***********************99 PP

  Guanylate_cyc   95 es....keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182 
                     +s    +e++++rvGi+tG+v+agviG+kk+ yd+wG+t+n+Asrmes++ +g+iq+s++tye   + +f+++er + +vkGkg+ ++y+l+
     EFC38290.1 1609 KSgkhpSEQINIRVGINTGSVIAGVIGRKKFAYDLWGDTINTASRMESNSIPGRIQISRSTYERVYDLGFTFEER-HLNVKGKGECIAYMLH 1699
                     9977777*****************************************************************998.69************97 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.2   0.2   6.1e-18   1.4e-14       7     104 .]    1376    1476 ..    1369    1476 .. 0.93

  Alignments for each domain:
  == domain 1  score: 54.2 bits;  conditional E-value: 6.1e-18
       PAS_9    7 dnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.......kerevevvlirkngetfwvlltaspvkdddgelvgii 96  
                    ++  i+ +N+aa +++Gy+  e +g+s+ +lf  +++++++++++++++         k  + e+++irkn++ f+ ++++++   +++ +v   
  EFC38290.1 1376 SGEKVDIEIFNPAAQKIFGYNQTETIGRSLYQLF--EKNEQSKIKNLIDEMLVnaargdsKGDSIELECIRKNQTSFPSRVNIFATLHNSQSVVT-- 1468
                  555557999*************************..***********************************************************.. PP

       PAS_9   97 vilrDite 104 
                  ++++Dit+
  EFC38290.1 1469 CFIKDITT 1476
                  ******95 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7   0.0   5.3e-11   1.2e-07       3     113 .]    1361    1474 ..    1359    1474 .. 0.95

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 5.3e-11
                  HHHHHHHSSSEEEEEE.TTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEEE CS
         PAS    3 lraileslpdpifvvD.edgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevras 94  
                  +r+il+++ d+ ++   e+ +i  +N+aa++++G+++ e +g+sl+ l+  +++++ + l+ + l ++ ++ ++  s++l    ++++ ++ +v+  
  EFC38290.1 1361 VRSILNASVDGAVMCSgEKVDIEIFNPAAQKIFGYNQTETIGRSLYQLFEKNEQSKIKNLIDEMLVNAARGDSKGDSIELecirKNQTSFPSRVNIF 1457
                  78999**9999999999999**********************************************************9999999************ PP

                  EEEETTEEEEEEEEEEEES CS
         PAS   95 pvrdaggeilgflgvlrdi 113 
                   +++ ++    + ++++di
  EFC38290.1 1458 ATLHNSQS--VVTCFIKDI 1474
                  ****9998..89***9998 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   4.8e-05      0.11       1      60 [.    1365    1425 ..    1365    1432 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 4.8e-05
       PAS_4    1 ldslpdalavl.dpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvl 60  
                  l+++ d+ +++ ++   ++  N+aa+++fg+ + e +G++l++l+ +  +  + + ++++l
  EFC38290.1 1365 LNASVDGAVMCsGEKVDIEIFNPAAQKIFGYNQTETIGRSLYQLFEKNEQSKIKNLIDEML 1425
                  57888888888899999999***************************99999999888877 PP

>> PAS_10  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.63   1.4e+03       1      25 [.     945     969 ..     945     980 .. 0.91
   2 ?    9.5   0.0   0.00063       1.4       9      65 ..    1370    1427 ..    1363    1449 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.63
      PAS_10   1 lnnlLnstpieltflDdnlqirrFt 25 
                 l+ +L+s p+ l++++++  ++ ++
  EFC38290.1 945 LESFLSSYPFMLLYFNSERMVTAYS 969
                 678*****************99997 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00063
      PAS_10    9 pieltflDdnlqirrFtpaakklfklipad.vGrpladihpkkavknveeviealrtg 65  
                  + +++   ++ +i  F+paa+k+f +++++ +Gr+l ++ +k+++++++++i+++  +
  EFC38290.1 1370 DGAVMCSGEKVDIEIFNPAAQKIFGYNQTEtIGRSLYQLFEKNEQSKIKNLIDEMLVN 1427
                  55556666788999***********9886439**********9999999999887654 PP

>> DUF3886  Protein of unknown function (DUF3886)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   5.4   0.00019      0.43      13      50 ..     666     703 ..     664     711 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00019
     DUF3886  13 nedvlekLkakkkeLkeeeekrkeeekarreeerkare 50 
                 n+d+++ L a +++L+eee kr+++ +++r ++ k ++
  EFC38290.1 666 NKDAAQELYAEASSLEEEETKRNAQLRKKRNQKSKFKN 703
                 89****************************99988665 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.7       2.7   6.1e+03      75     197 ..     676     697 ..     658     711 .. 0.48
   2 ?   11.3   0.0   7.8e-05      0.17     193     221 .]    1479    1507 ..    1463    1507 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.7
       HNOBA  75 kkksikeeeaeknseklqasaeeartdlkekkredrnvkksrslkLkGqmlyikeensllFlcsPvvenleelrkvGlylsDlplhdssrelvlagiqq 173
                 +++s +                                                                                             
  EFC38290.1 676 EASSLE--------------------------------------------------------------------------------------------- 681
                 222222............................................................................................. PP

       HNOBA 174 saelelaldqleeksaeLeesmke 197
                         +++ +++a+L ++ ++
  EFC38290.1 682 --------EEETKRNAQLRKKRNQ 697
                 ........2333333333333222 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 7.8e-05
       HNOBA  193 esmkeleeekkrtdeLLysmiPkevAerL 221 
                  + ++ l eekk ++eLL +++P  vA++L
  EFC38290.1 1479 KHNSLLTEEKKHSEELLLNILPSAVASKL 1507
                  667789********************987 PP

>> TSNAXIP1_N  Translin-associated factor X-interacting N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1       0.6   1.3e+03      53      89 ..     588     624 ..     583     641 .. 0.75
   2 ?    4.5   3.0     0.019        43      51      98 ..     656     703 ..     637     710 .. 0.86
   3 ?    3.5   0.0     0.041        93      30      48 ..     857     875 ..     847     876 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.6
  TSNAXIP1_N  53 lyiahllesqreaqylkakl.ktlsessdkraleleek 89 
                 +++ +l+++q+e+++l+++  k++ ++++ r  ++e  
  EFC38290.1 588 EVMFILERRQNELKALHRMFwKEMLQECVLRD-KIESI 624
                 678899**********9999999999998665.55554 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.019
  TSNAXIP1_N  51 Yelyiahllesqreaqylkaklktlsessdkraleleekreelralek 98 
                 + +yi++++ ++ +aq l a+ ++l+e+++kr  +l++kr++ +++++
  EFC38290.1 656 FAKYIEEFKFNKDAAQELYAEASSLEEEETKRNAQLRKKRNQKSKFKN 703
                 5689***********************************887777666 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.041
  TSNAXIP1_N  30 FedlieefkaYkdlLseIK 48 
                  e+++e++++Y+d+L++++
  EFC38290.1 857 HEEMLEHINTYRDILKSVR 875
                 5899************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1763 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1278  (0.0712812); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.02u 0.28s 00:00:01.30 Elapsed: 00:00:00.49
# Mc/sec: 10792.27
//
Query:       EFC38291.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.015   15.2   0.1      0.018   14.9   0.1    1.3  1  TMV_coat  Virus coat protein (TMV like)
      0.043   13.1   0.2      0.055   12.7   0.2    1.2  1  DUF4849   Putative glycoside hydrolase Family 18, chitinase_1


Domain annotation for each model (and alignments):
>> TMV_coat  Virus coat protein (TMV like)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   0.1     2e-06     0.018     106     153 ..      84     127 ..      28     137 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2e-06
                 S...........SST-SSTTT.HHHHHHHHHHHHHHHHHHHHHHHCCT CS
    TMV_coat 106 aeaegkttrttenqaatataeltleeeqpleDaaLaialalaelelar 153
                    +gk+t+tt++  +  t     +eeq+++  +L+++++++ +  + 
  EFC38291.1  84 T--KGKATKTTTRRNSSHTHV--DREEQKQNARSLHYRNVVQKIRKQH 127
                 3..477777777666666665..489****************994443 PP

>> DUF4849  Putative glycoside hydrolase Family 18, chitinase_18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2   6.2e-06     0.055     174     227 ..     100     157 ..      76     160 .] 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 6.2e-06
     DUF4849 174 kalkewkksntdklLvlqgepqslvdeni....lskfdyiilktasstddadlalkll 227
                  ++   +++++ ++L     +q++ ++++    lskf+y++l++ +st+ + l+  ++
  EFC38291.1 100 THVDREEQKQNARSLHYRNVVQKIRKQHLnmkwLSKFEYLVLSICDSTNSNWLENSVN 157
                 333344677889*************99877799*****************99987776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1466  (0.081767); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 996.07
//
Query:       EFC38292.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1103  (0.0615204); expected 358.6 (0.02)
Passed bias filter:                      533  (0.0297284); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.34s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 884.84
//
Query:       EFC38293.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-14   53.6   8.1    4.2e-14   53.2   8.1    1.1  1  RhoGEF           RhoGEF domain
  ------ inclusion threshold ------
      0.013   15.3   1.9        2.5    8.0   0.1    2.3  2  DUF2202          Uncharacterized protein domain (DUF2202)
      0.037   14.0   0.7       0.11   12.5   0.2    2.0  2  Nitrate_red_del  Nitrate reductase delta subunit
       0.11   12.9   0.0       0.18   12.2   0.0    1.3  1  DUF3486          Protein of unknown function (DUF3486)
       0.39   10.7   6.9       0.11   12.4   1.0    2.6  3  P4Ha_N           Prolyl 4-Hydroxylase alpha-subunit, N-termin
       0.41   11.0   4.6        2.4    8.5   0.1    2.8  2  FCH              Fes/CIP4, and EFC/F-BAR homology domain


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.2   8.1   1.4e-17   4.2e-14       1     179 [.       4     189 ..       4     192 .. 0.82

  Alignments for each domain:
  == domain 1  score: 53.2 bits;  conditional E-value: 1.4e-17
                 HHHHHHHHHHHHHHHHHHHHHHTHCCCHHCT...............CCHHHHHHHHCTTHHHHHHHHHHHHHHHHHHHH.HHHTTSS-S-SHHHHHHHH CS
      RhoGEF   1 vikElleTErsYvrdLkvlvevylkplsele...............vlseeeikiiFsnieeilelhrsflleeLeerlkeseeqkeaqsigdvflkfa 84 
                 +++ l++ E+sY+ +L++l+++yl pl ++e                 +e+ +++i s ++ i +lh +f l++Le+      +++++  +g++f + +
  EFC38293.1   4 IVQTLIQAEKSYIDQLNTLIQKYLLPLADEEssplvhsvchqseehHQEENYLHNISSSLNIITKLH-HFTLTRLEDFS----NKNNYAGFGSLFSTVS 97 
                 6789********************8888888899999999888877777777789************.99999998877....5666788********* PP

                 ST.HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHTSGGGTT--HHHHTTH.HHHHHHHHHHHHHHHHHTS-TTSHHH.HHHHHHHHHHHHHHH CS
      RhoGEF  85 dk.fkkYseYcsnypnalkllkelskknkkfkafleeaeerpecskldLeslLik.PvqRlprYpLLLkellkntpeshpdy.ealkkaleaikevas 179
                 ++ +  Y++Y s  p++l++l++++++n+ +k++l+e       ++ +L +lL+k P   l  Y+  L++   + ++++++    l+   + i+++a+
  EFC38293.1  98 SQlLAPYKQYYSSVPKILSYLEREKQTNDAYKKWLTEN------DESKLVDLLVKsPQDHLNFYVTQLNNYGSSSDDEKQNItTSLDYLTKTIESIAQ 189
                 994446*****************999999998888873......456788888873666777788888888887777777666667777777777765 PP

>> DUF2202  Uncharacterized protein domain (DUF2202)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.1   0.00082       2.5      29      59 ..       3      33 ..       1      62 [. 0.87
   2 ?    7.1   0.2    0.0015       4.4       7      61 ..     116     171 ..     111     201 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00082
     DUF2202 29 qiflniakseqthtdavksllekYeledpvk 59
                +i + + ++e++++d++++l++kY l+ +++
  EFC38293.1  3 EIVQTLIQAEKSYIDQLNTLIQKYLLPLADE 33
                5788999*****************9876555 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0015
     DUF2202   7 ymreeeklarDvYle.lYdrwklqiflniakseqthtdavksllekYeledpvked 61 
                    e ek   D Y + l +  + ++   ++ks q h++   + l++Y+ +  ++++
  EFC38293.1 116 SYLEREKQTNDAYKKwLTENDESKLVDLLVKSPQDHLNFYVTQLNNYGSSSDDEKQ 171
                 55678899999998746778888899999999999999988899999877655554 PP

>> Nitrate_red_del  Nitrate reductase delta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.49   1.5e+03     111     130 ..      10      29 ..       1      33 [. 0.72
   2 ?   12.5   0.2   3.7e-05      0.11      25     117 ..      81     180 ..      57     197 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.49
  Nitrate_red_del 111 eeaealleaqkafleehllp 130
                      +++++++++++++++++llp
       EFC38293.1  10 QAEKSYIDQLNTLIQKYLLP 29 
                      34567999999999999987 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 3.7e-05
  Nitrate_red_del  25 dllelaaeYtrLFlgpgrrsasPyesvYls.ekkgllfgest....levrefyrqagle..vaeefneppDHlaveLeflahLaereaeaeea. 110
                      + ++  a + +LF   + + ++Py  +Y s   k l + e+      + ++++++++ +  v+  ++ p+DHl ++   l +  +++ +++++ 
       EFC38293.1  81 SNKNNYAGFGSLFSTVSSQLLAPYKQYYSSvP-KILSYLEREkqtnDAYKKWLTENDESklVDLLVKSPQDHLNFYVTQLNNYGSSSDDEKQNi 173
                      55556678999***99**************52.334444555011345555555555555555567899***********99999998877777 PP

  Nitrate_red_del 111 .eeaeall 117
                       + + ++l
       EFC38293.1 174 tT-SLDYL 180
                      52.33332 PP

>> DUF3486  Protein of unknown function (DUF3486)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   6.1e-05      0.18      56     141 ..     107     197 ..      77     204 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.1e-05
     DUF3486  56 yaqrleevaeklresreiaealveelgdeedddvtealiellqtllfellmalee.....eeeeeidpkeakeLakalaklerasvaskkr 141
                 y + + +++  l++ ++  +a  + l +++++++ ++l++  q++l+  + +l++     ++e++  + ++  L+k+++++++a+ a+++ 
  EFC38293.1 107 YYSSVPKILSYLEREKQTNDAYKKWLTENDESKLVDLLVKSPQDHLNFYVTQLNNygsssDDEKQNITTSLDYLTKTIESIAQAQHAKHQP 197
                 677788889999999999999999999**************************99****999999999*****************998865 PP

>> P4Ha_N  Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.0   3.8e-05      0.11       5      86 ..       5      88 ..       2     113 .. 0.74
   2 ?    0.5   0.1       0.2   5.8e+02      18      44 ..     113     139 ..      94     165 .. 0.69
   3 ?    0.0   0.1      0.27   7.9e+02      16      46 ..     156     186 ..     148     202 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.8e-05
      P4Ha_N  5 lekLlklErelveeLesyieeeekkleklkr..fleeleeehesakedkeeylsnPlnaFklikRltsdW.eeleklleesesee 86
                +++L+++E+ ++++L++ i++    l++ ++  +++++ +++ ++++++e+yl+n  ++  +i +l++   ++le++ ++++ ++
  EFC38293.1  5 VQTLIQAEKSYIDQLNTLIQKYLLPLADEESspLVHSVCHQS-EEHHQEENYLHNISSSLNIITKLHHFTlTRLEDFSNKNNYAG 88
                57899**********999999855555544433444444443.33556799***************9977688888888777766 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.2
      P4Ha_N  18 eLesyieeeekkleklkrfleeleeeh 44 
                 ++ sy+e+e++  +  k++l+e +e +
  EFC38293.1 113 KILSYLEREKQTNDAYKKWLTENDESK 139
                 566788888888888888777755554 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.27
      P4Ha_N  16 veeLesyieeeekkleklkrfleeleeehes 46 
                 v++L++y +    + +++   l+ l +  es
  EFC38293.1 156 VTQLNNYGSSSDDEKQNITTSLDYLTKTIES 186
                 6677777777766666666666666666544 PP

>> FCH  Fes/CIP4, and EFC/F-BAR homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.1   0.00082       2.4      21      57 ..       3      37 ..       1      76 [. 0.75
   2 ?    3.1   0.9     0.038   1.1e+02      52      75 ..     151     191 ..      94     193 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00082
                HHHHHHHHHHHHHHHHHHHHCT----TT-.....HHH CS
         FCH 21 eflkeRaeiEkeYakkLqkLakkylkrrkkkseestl 57
                e ++   + Ek Y  +L+ L +kyl   ++ +ees++
  EFC38293.1  3 EIVQTLIQAEKSYIDQLNTLIQKYLL--PLADEESSP 37
                566777899***************98..555444443 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.038
                 ....................HHHHHHHHHHHHHHHHHHHHH CS
         FCH  52 s.................eestlvtawtvlleeteklaqsh 75 
                 +                 e++++ t+++ l +++e++aq++
  EFC38293.1 151 HlnfyvtqlnnygsssddEKQNITTSLDYLTKTIESIAQAQ 191
                 04444444444444455577899999999999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1415  (0.0789224); expected 358.6 (0.02)
Passed bias filter:                      565  (0.0315132); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.55
# Mc/sec: 1117.43
//
Query:       EFC38294.1  [L=545]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.3e-32  109.0  28.9    4.3e-17   61.8   5.0    3.3  3  Ion_trans_2  Ion channel
    5.4e-10   38.9  28.1    1.3e-05   24.5  11.7    2.5  2  Ion_trans    Ion transport protein
  ------ inclusion threshold ------
       0.77    9.6   6.6       0.72    9.7   1.6    2.6  2  Lig_chan     Ligand-gated ion channel


Domain annotation for each model (and alignments):
>> Ion_trans_2  Ion channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.3      0.26   1.5e+03      45      76 ..     245     275 ..     243     278 .. 0.57
   2 !   61.8   5.0   7.2e-21   4.3e-17      20      78 ..     314     372 ..     302     373 .. 0.91
   3 !   56.4  10.3   3.6e-19   2.1e-15       3      77 ..     430     501 ..     418     503 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.26
                  STT-----HHHHHHHHHHHHHHHHHHHHHHHH CS
  Ion_trans_2  45 vpetdagrlftivyillGlalfalflavlgkv 76 
                  ++++   + ++++++l+  ++++l++a + ++
   EFC38294.1 245 TCKQFS-KNCCYALLLIVSIFIFLLVASVPIW 275
                  555444.6666666666666666666666555 PP

  == domain 2  score: 61.8 bits;  conditional E-value: 7.2e-21
                  .T---HHHHHHHHHHHHTTS----SSTT-----HHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Ion_trans_2  20 wekwsfldalYfsfvtltTiGYGdivpetdagrlftivyillGlalfalflavlgkvlt 78 
                     w ++++lYfs+vt+tT+GYGd+vp+t ag+lf++++++lGla++++ + vl+k l+
   EFC38294.1 314 IDHWYYTNCLYFSTVTFTTVGYGDVVPQTVAGKLFVVLFGILGLATMGAMTGVLFKKLM 372
                  45789*************************************************99987 PP

  == domain 3  score: 56.4 bits;  conditional E-value: 3.6e-19
                  HHHTCHHHHHHHHT....T---HHHHHHHHHHHHTTS----SSTT-----HHHHHHHHHHHHHHHHHHHHHHHHH CS
  Ion_trans_2   3 lllvlifgaviysleegwekwsfldalYfsfvtltTiGYGdivpetdagrlftivyillGlalfalflavlgkvl 77 
                  + ++ i+ga+i++     e+w f d+lYf+f+tltTiGYGd+  ++ + ++f i++i+ G++l++++la++g v+
   EFC38294.1 430 VATYSIVGALIFMA---FEDWVFGDSLYFVFITLTTIGYGDLKLKNSGSKFFLIFFIICGIGLLGILLALIGGVF 501
                  55667777788888...9***************************9999*********************99876 PP

>> Ion_trans  Ion transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   8.5     7e-08   0.00042     134     234 ..     256     368 ..     244     378 .. 0.62
   2 !   24.5  11.7   2.2e-09   1.3e-05     125     239 ..     418     503 ..     377     507 .. 0.74

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 7e-08
                 HHHHHHHHHHHHHHH...HHHHTTSCCCC..CCSCCSTSSSTTTSSSSSS..................HHHHHHHHHHHHTTSSHHHHHHHHHHHSHHH CS
   Ion_trans 134 lllllvvlfifalig...vqlfkgklrek..necaktwenpnngntnFdn..................fftallwlfrlmttegwgdilyatldekskv 209
                 +lll+v +fif l++   + l +g++  +  n     + ++n+  +n+++                  + ++l++++++ tt+g+gd++++t  +k   
  EFC38294.1 256 ALLLIVSIFIFLLVAsvpIWLIEGTYEAQtlN-----QMTSNFTINNVTTssnetditydlfnidhwyYTNCLYFSTVTFTTVGYGDVVPQTVAGK--- 346
                 33333333444333321144445555533331.....22222333332225556666777777899******************************... PP

                 HHHHHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans 210 aliyfvifiilgsflllNlliavia 234
                    +fv+++ + ++ ++  + +v  
  EFC38294.1 347 ---LFVVLFGILGLATMGAMTGVLF 368
                 ...7777777777766666666655 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 2.2e-09
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSCCCCCCSCCSTSSSTTTSSSSSS..HHHHHHHHHHHHTTSSHHHHHHHHHHHSHHHHHHHHHHHHHHH CS
   Ion_trans 125 rsvkdllnvlllllvvlfifaligvqlfkgklreknecaktwenpnngntnFdn..fftallwlfrlmttegwgdilyatldekskvaliyfvifiilg 221
                 + + +++++    ++++  ++++g  +f                       F++  f+++l+++f ++tt+g+gd+  ++ ++k      +f+if+i++
  EFC38294.1 418 HPLSQIVYF----FFLVATYSIVGALIF---------------------MAFEDwvFGDSLYFVFITLTTIGYGDLKLKNSGSK------FFLIFFIIC 485
                 334444444....444444444454444.....................22333349***************************......********* PP

                 HHHHHHHHHHHHHHHHHH CS
   Ion_trans 222 sflllNlliaviadnfqe 239
                 ++ ll +l+a+i   f +
  EFC38294.1 486 GIGLLGILLALIGGVFKR 503
                 ************988876 PP

>> Lig_chan  Ligand-gated ion channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   1.6   0.00012      0.72       6      83 ..     261     357 ..     255     375 .. 0.84
   2 ?    1.6   0.3     0.038   2.3e+02      13      80 ..     381     484 ..     375     492 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00012
                 XXXXTXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..................XXXHHHHHHHHHHHHHHHHHHH.HXXXXXXXXXXXXXXXXXXXXX CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxx RF
    Lig_chan   6 lsvlvalilvsivlflverfspyewrepeeaaet..................veneftlsnslwfslgalvqqG.cdesprsvsgRivvavWwffvl 83 
                 +s++++l++ s+ ++l+e   + +  ++ +++ t                     ++ + n+l+fs+ +++  G +d  p++v+g++ v+++ ++ l
  EFC38294.1 261 VSIFIFLLVASVPIWLIEGTYEAQTLNQMTSNFTinnvttssnetditydlfNIDHWYYTNCLYFSTVTFTTVGyGDVVPQTVAGKLFVVLFGILGL 357
                 5778888889999999998877777766555555788888999999999999999*******************99***********9999877666 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.038
                 XXXXXXXXXXXXXXXXXXXXXXXXXXX...................................XXXHHHHHHHHHHHHHHHHHHH.HXXXXXXXXXXXXX CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx...................................xxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxx RF
    Lig_chan  13 ilvsivlflverfspyewrepeeaaet...................................veneftlsnslwfslgalvqqG.cdesprsvsgRivv 75 
                 ++  i++f+++    +++++ +++ +                                    + +++ + +sl+f++ +l+  G +d + ++  +++  
  EFC38294.1 381 LISNIIVFFIKLCMSCSFNSTQRKTSRiervvsvivkhplsqivyffflvatysivgalifmAFEDWVFGDSLYFVFITLTTIGyGDLKLKNSGSKFFL 479
                 566677777777777777776544333567777777777777777777777777777777766777888888888888888888777777777777777 PP

                 XXXXX CS
                 xxxxx RF
    Lig_chan  76 avWwf 80 
                 +++++
  EFC38294.1 480 IFFII 484
                 66655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (545 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1079  (0.0601818); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.76u 0.34s 00:00:01.10 Elapsed: 00:00:00.55
# Mc/sec: 2967.23
//
Query:       EFC38295.1  [L=468]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-29  103.5   4.7    1.3e-29  103.5   4.7    1.9  2  G-alpha   G-protein alpha subunit
      8e-05   22.9   6.9     0.0012   19.1   1.7    3.7  3  LRR_4     Leucine Rich repeats (2 copies)
     0.0015   18.4   0.2       0.57   10.1   0.0    3.2  2  F-box     F-box domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.5   4.7   2.2e-33   1.3e-29     138     348 ..       2     209 ..       1     213 [. 0.84
   2 ?    0.3   0.1     0.052   3.1e+02     135     166 ..     343     381 ..     247     451 .. 0.74

  Alignments for each domain:
  == domain 1  score: 103.5 bits;  conditional E-value: 2.2e-33
                 CCSHHHHHHHCCGCCTT......--TTHHHHHCT..HHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECE CS
     G-alpha 138 wndpgiqelyerrnkik......lednaeyFldd..leritspdYlptddDilkarlktvGisetkfevdsklefrivdvgGqrserkkWvpffddvda 228
                  +d g+q+++ ++ +i+      +++ + yF ++  ler +++  +p  +D  +  +ktvGi e ++ +     ++ +d+gGqr er  W+ ++++ ++
  EFC38295.1   2 YHDSGFQKCIHEK-EIEgnciseISETVSYFNQRnvLERYMKQRLIP--KDYARIYMKTVGIVERTV-C----GVTCFDTGGQRCERSRWEDLITSSEC 92 
                 5899999999976.6664443345699999977689***********..889999999*******99.4....478*****************977666 PP

                 .EEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS.-GGGCCTT--H.CCHHHHHHHHHHHHHHCCCCCCES CS
     G-alpha 229 .iiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg.klskyfpsyegrkndlesvlkylrnkFeeihkeksn 325
                    F++sls+ ++++ye +  nr+++s +lF++++++k+ k+   +++++K+++l+eK+++g kls++f++++g+++d ++v +++++kF+++ +    
  EFC38295.1  93 kHCFVISLSQCNELCYELSDLNRFDDSYRLFQSVLERKEIKRL--YVIFTKFEVLREKIRRGyKLSSFFKDFKGNDSDPNEVKDFIIEKFLNLDR---- 185
                 368*************************************876..99**********************************************55.... PP

                 GGSCEEEEEE..-TT-HHHHHHHHH CS
     G-alpha 326 nrrkiythft..satdtkevqkvie 348
                  + ki  hf+  +++  +++ ++++
  EFC38295.1 186 -ESKIAKHFVvdCCFHRESLVGMFN 209
                 .445555544114566665555555 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.052
                 HHHCCSHHHHHH..HCCGCCTT--.TTHHHHHCT....H CS
     G-alpha 135 kaLwndpgiqel..yerrnkikle.dnaeyFldd....l 166
                 + L++d  +++l  ++ +n++ l+ ++ eyF+++     
  EFC38295.1 343 QHLVKDDRFKSLeyLDLSNNYLLKeEDFEYFFENqqfrN 381
                 445566666655324455555553488888888766552 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.3     5e-06      0.03       4      36 ..     328     364 ..     327     371 .. 0.74
   2 !   19.1   1.7   2.1e-07    0.0012       1      40 [.     352     396 ..     352     400 .. 0.78
   3 ?    1.6  11.3     0.068   4.1e+02       1      39 [.     405     446 ..     405     456 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 5e-06
                 -EEE--SS---.E-S-.HH..H.-TT--EEE-.-S--- CS
       LRR_4   4 evLdLsnNqlt.dipl.le..k.lpnLkeLdLsgNnli 36 
                 +++dL+++ lt di   l     +++L++LdLs+N ++
  EFC38295.1 328 KFIDLQSCFLTsDIFQhLVkdDrFKSLEYLDLSNN-YL 364
                 67899999999777777447755*********666.66 PP

  == domain 2  score: 19.1 bits;  conditional E-value: 2.1e-07
                 SS--EEE--SS.---E-S-...HH..H-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnN.qltdipl...le..klpnLkeLdLsgNnlitdld 40 
                 ++Le+LdLsnN  l++ ++   +e  ++ nLk L + ++n+  +l+
  EFC38295.1 352 KSLEYLDLSNNyLLKEEDFeyfFEnqQFRNLKILKMDFCNFS-NLS 396
                 68*********8899999977644756*********888443.554 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.068
                 SS--EEE--..SS.---E-S-HH.H-TT.--EEE-..-S-----G CS
       LRR_4   1 pnLevLdLs..nN.qltdiplle.klpn.LkeLdL.sgNnlitdl 39 
                 p+L++L+L+   N +++d++ l  +l n L+eL++ ++N  + d+
  EFC38295.1 405 PKLQSLSLNgvKNlNISDLSKLVdNLGNtLTELNViHSN--L-DI 446
                 79*******666989******88458889**99984555..4.54 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   9.5e-05      0.57      14      34 ..     281     301 ..     276     305 .. 0.86
   2 !    4.6   0.1    0.0051        31      15      44 ..     324     353 ..     324     357 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 9.5e-05
                 HHHTS-HHHHHHHCTT-HHHH CS
       F-box  14 ILerLplsdllalrrVSkgwr 34 
                 + e+ +l d+l++r+V++ ++
  EFC38295.1 281 VSEFFDLDDILNMRLVCREFN 301
                 668999************886 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0051
                 HHTS-HHHHHHHCTT-HHHHHHHTTHHHHH CS
       F-box  15 LerLplsdllalrrVSkgwrilidsdrlwc 44 
                 ++++ ++dl ++ ++S  +  l+++dr++ 
  EFC38295.1 324 FKYVKFIDLQSCFLTSDIFQHLVKDDRFKS 353
                 799************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.57
# Mc/sec: 2481.68
//
Query:       EFC38296.1  [L=474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-32  112.5   0.3    3.6e-32  111.8   0.3    1.3  1  Pkinase         Protein kinase domain
    8.3e-26   90.8   0.0    1.3e-25   90.2   0.0    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
    3.7e-06   27.4   0.0    1.9e-05   25.1   0.0    2.2  2  Ank_2           Ankyrin repeats (3 copies)
    0.00012   21.0   0.0    0.00021   20.2   0.0    1.3  1  Pkinase_fungal  Fungal protein kinase
     0.0021   18.4   0.2      0.028   14.9   0.0    2.9  3  Ank_3           Ankyrin repeat
  ------ inclusion threshold ------
      0.015   15.9   0.0      0.083   13.5   0.0    2.3  2  Ank_4           Ankyrin repeats (many copies)
      0.019   15.2   0.0       0.15   12.4   0.0    2.4  2  Ank_5           Ankyrin repeats (many copies)
      0.084   12.2   0.0       0.31   10.4   0.0    1.8  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.8   0.3   1.6e-35   3.6e-32       6     259 ..     204     450 ..     200     453 .. 0.80

  Alignments for each domain:
  == domain 1  score: 111.8 bits;  conditional E-value: 1.6e-35
                 EEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHH CS
     Pkinase   6 klGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladllerkgslseeeakki 103
                  lG+G++G Vy+++   ++  vA K+ ++           ++Ei+i++ +  h+ +v+l++ ++++   +l++e ++       +++ ++++  ++ + 
  EFC38296.1 204 YLGNGANGAVYSVL--MNNVPVAEKISNNIG---------TSEIEIMNGICeHDGVVKLLHHYNQDGIEHLFMEKMDDSLSSFSITEPTIIELVQILFS 291
                 699*********99..689999999877653.........469****99888*************************65444445577789999***** PP

                 HHHHHHHHHHHHHTTEE-SS-SGGGEEEET.TTE........EEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH...TTSCB.SHHHHHHHHHHHHH CS
     Pkinase 104 akqilegleylHskgiiHrDlKpeNiLide.kge........lKitDFGlakelesssk.ltsfvgtseYlAPEvl...keney.skkvDvWslGvily 188
                 + ++   ++ylHsk++iH D+Kp+NiL+++ +          +K++DF+++  +++ ++   +  gt +Y+APE+    +++ +  ++ D++s Gv++ 
  EFC38296.1 292 LVKVSDTMKYLHSKNVIHYDIKPNNILVKKmR-IdgveiidnVKLSDFDVSLTVDKPETySCTTAGTLYYMAPELRnkqQDTVFvFRALDIFSFGVTMH 389
                 *****************************642.235577777**************999777999**********9754344446789*********** PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                 +l++g  p +  +        +  + +++++++   +++   +e  +++  l  k+ + dpk+R+t+e++ 
  EFC38296.1 390 TLISGYRPANMAD-------VFGSFISVVQLVER--FNF-LTQEQAQKIHLLGMKCTHIDPKERPTFEDIF 450
                 **********222.......22233333333332..222.23455677888889*************9987 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.2   0.0   5.9e-29   1.3e-25       6     259 .]     204     453 ..     200     453 .. 0.84

  Alignments for each domain:
  == domain 1  score: 90.2 bits;  conditional E-value: 5.9e-29
                  EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBH CS
  Pkinase_Tyr   6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekltl 102
                   lG+Ga G V++  ++      +v Va K+ ++          ++e++im+ + +h+ +vkll  + +++   + +e ++  +L++f  ++  + ++l
   EFC38296.1 204 YLGNGANGAVYSVLMN------NVPVAEKISNNI--------GTSEIEIMNGIcEHDGVVKLLHHYNQDGIEHLFMEKMDD-SLSSFSITE-PTIIEL 285
                  5888888888888887......788888877433........3468*******************************9986.899999888.999*** PP

                  HHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE........TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE....EEHHHHH CS
  Pkinase_Tyr 103 kdllsfalqvAkGmeyLeskklvHrdlaarNvLlse........nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk....ftsksDv 188
                   ++l   ++v++ m+yL+sk+++H d+   N+L+++         + vk+sDf ++ ++ k ++y+ ++     + +mapE  ++++    +  + D+
   EFC38296.1 286 VQILFSLVKVSDTMKYLHSKNVIHYDIKPNNILVKKmridgveiIDNVKLSDFDVSLTVDKPETYSCTT--AGTLYYMAPELRNKQQdtvfVFRALDI 381
                  ************************************99999988889************7777776555..56789******99998888666788** PP

                  HHHHHHHHHHHTTSSGTTTTS.HHHHHHHHHHTTEES-BB.TTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 189 WsfGvllwEiftlgespypgl.kneevleklkegkrlekp.ekcpeelyelmkkcweedpeeRptfselvekl 259
                  +sfGv+++ +++ g +p +      ++++ ++  +r +   ++  ++++ l +kc + dp+eRptf+++ ++l
   EFC38296.1 382 FSFGVTMHTLIS-GYRPANMAdVFGSFISVVQLVERFNFLtQEQAQKIHLLGMKCTHIDPKERPTFEDIFDEL 453
                  ************.9999877744445666666666655430334788899999***************98775 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.0   8.6e-09   1.9e-05      11      78 ..      27      95 ..      18      98 .. 0.75
   2 ?   -3.4   0.0       6.7   1.5e+04       7      18 ..     245     255 ..     240     266 .. 0.60

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 8.6e-09
       Ank_2 11 elvklLlegadpn.kngktaLhyAakngnleivklLleh...ad.ndgrtpLhyAarsghleivklLlekgad 78
                +l++ L+ +++ n    +t L++A+k+g++++vk+Ll+    +d ++g    h+++r+ h   v++Ll +g++
  EFC38296.1 27 SLLDVLIPEKNKNyPPARTLLYIACKYGQVKVVKYLLKSmplVDyKNGG--CHNSCRNHH--DVRILLSSGVE 95
                577788844444542569*******************988987775555..4****8665..88888877765 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 6.7
       Ank_2   7 n.gnlelvklLl.e 18 
                 + g   +vklL+ +
  EFC38296.1 245 HdG---VVKLLHhY 255
                 335...66666532 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   9.6e-08   0.00021     308     387 ..     288     367 ..     279     382 .. 0.80

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 9.6e-08
  Pkinase_fungal 308 llealrDaIkghrsLflkagiLHrDiSenNilitdskke...gerkglLiDLDlakelsddssesgarertGTleFmaievlk 387
                     +l +l  +  + + L+  ++++H Di  nNil+   + +     ++  L+D+D+  +++++++   +++  GTl++ma e+ +
      EFC38296.1 288 ILFSLVKVSDTMKYLH-SKNVIHYDIKPNNILVKKMRIDgveIIDNVKLSDFDVSLTVDKPET--YSCTTAGTLYYMAPELRN 367
                     5555666666778899.9****************66555555678899***********7544..4589*********88765 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   1.2e-05     0.028       3      23 ..      44      64 ..      43      68 .. 0.94
   2 ?   -2.6   0.0       6.6   1.5e+04      10      26 ..      80      93 ..      77      96 .. 0.63
   3 ?   -1.4   0.0       2.5   5.6e+03      14      29 ..     133     147 ..     130     148 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.2e-05
       Ank_3  3 etpLhlAarsgnleivkfLle 23
                +t+L++A+++g +++vk+Ll+
  EFC38296.1 44 RTLLYIACKYGQVKVVKYLLK 64
                7*******************8 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 6.6
       Ank_3 10 arsgnleivkfLlenkg 26
                +r+ + + v+ Ll   g
  EFC38296.1 80 CRNHH-D-VRILLS-SG 93
                55444.4.898887.55 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 2.5
       Ank_3  14 nleivkfLlenkgadv 29 
                 n +i+k++l  + ad+
  EFC38296.1 133 NNSILKYMLA-PQADL 147
                 44579****9.99986 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   3.7e-05     0.083      36      55 .]      44      63 ..      27      63 .. 0.86
   2 ?   -3.4   0.0       7.5   1.7e+04      17      25 ..      86      94 ..      76      96 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.7e-05
       Ank_4 36 etalhiAakrgnveilklLl 55
                +t+l+iA+k g+v+++k+Ll
  EFC38296.1 44 RTLLYIACKYGQVKVVKYLL 63
                69*****************8 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 7.5
       Ank_4 17 vrlLlekga 25
                vr+Ll++g+
  EFC38296.1 86 VRILLSSGV 94
                567777776 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   6.8e-05      0.15      18      43 ..      45      72 ..      29      74 .. 0.82
   2 ?   -1.4   0.0       1.4   3.2e+03      29      44 ..     134     149 ..     133     152 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.8e-05
       Ank_5 18 tpLhvAakygaadvvrlLl..argadln 43
                t L +A+kyg   vv++Ll  ++ +d++
  EFC38296.1 45 TLLYIACKYGQVKVVKYLLksMPLVDYK 72
                99*****************888877765 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.4
       Ank_5  29 advvrlLlargadlnl 44 
                  ++++++la++adl+l
  EFC38296.1 134 NSILKYMLAPQADLML 149
                 57999*******9987 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.79   1.8e+03      88     110 ..     141     164 ..     134     183 .. 0.72
   2 ?   10.4   0.0   0.00014      0.31     125     156 ..     293     324 ..     289     343 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.79
         Kdo  88 leyrAll.lterlegaqdLedlla 110
                 l+ +A+l l ++l+++++L ++  
  EFC38296.1 141 LAPQADLmLNRKLDEFKSLGEYFS 164
                 565676526789******999876 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00014
         Kdo 125 kavgrliaklhragvnHadlyaknillqqeee 156
                  +v  +++ lh+ +v H d+ + nil+++   
  EFC38296.1 293 VKVSDTMKYLHSKNVIHYDIKPNNILVKKMRI 324
                 5789999********************99873 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       592  (0.0330191); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 2604.54
//
Query:       EFC38297.1  [L=434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.058   12.3   0.5       0.35    9.7   0.1    2.2  3  Mfa_like_2  Fimbrillin-like


Domain annotation for each model (and alignments):
>> Mfa_like_2  Fimbrillin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1     2e-05      0.35      71     158 ..     103     191 ..      95     198 .. 0.81
   2 ?   -1.8   0.0     0.061   1.1e+03     256     282 ..     327     353 ..     313     371 .. 0.81
   3 ?   -0.9   0.0     0.033   5.9e+02      91     133 ..     375     417 ..     350     426 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 2e-05
                 EEEEE.EE-TTS-E.EE-----EEE-SEEEEEEEE.ES-----TTSS----SS---EE--TTBTTTS-EEEEE------EEEEE---EE CS
  Mfa_like_2  71 slyPcsevdenGkleidasetPlyleaGtykfkii.sPakavskdgkvtidnGeyllatddrytqtestavtiekndeGvqvvklnPii 158
                 +l P  ++    + e   + +Ply + G y+f +   P   +   +   + nG +   t  r   t    + ++   +G+ vv  n +i
  EFC38297.1 103 TLLPIVQFPSSEEGELVKEISPLYQQEGNYYFTVRrNPKTNMDFILRTSVLNGTHFSFTTSRSYSTIYGMILVKSGRNGIAVVNNNLLI 191
                 566776666555555566779***********99625777778889999*****99999998889999999999999999999888776 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.061
                 EETTEEEEEEEEEECEEE-TTBEEEEE CS
  Mfa_like_2 256 kvngvPtqyttlvvgkqllaghsynyt 282
                 + n  P  y ++++g ++ +++  n  
  EFC38297.1 327 ARNSPPFVYSYSIKGIHISKSYEINLS 353
                 56888999*********9999988865 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.033
                 --EEE-SEEEEEEEEES-----TTSS----SS---EE--TTBT CS
  Mfa_like_2  91 tPlyleaGtykfkiisPakavskdgkvtidnGeyllatddryt 133
                   +  ++G   fk    + +   + k+ i+ G  ++atd r t
  EFC38297.1 375 FAVVCDTGMVIFKTGDSSVSPRVEFKIPINAGTQVFATDRRLT 417
                 5555677777777777777777888999999*******99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       365  (0.0203581); expected 358.6 (0.02)
Passed bias filter:                      274  (0.0152825); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2555.61
//
Query:       EFC38298.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3615  (0.201629); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.84u 0.37s 00:00:01.21 Elapsed: 00:00:00.58
# Mc/sec: 1832.72
//
Query:       EFC38299.1  [L=471]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      8e-07   29.3   0.6    1.9e-06   28.1   0.1    1.8  2  BTB             BTB/POZ domain
     0.0052   17.2   1.2     0.0052   17.2   1.2    2.6  3  LPAM_1          Prokaryotic membrane lipoprotein lipid attach


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.61   5.4e+03      70      94 ..     179     201 ..     165     224 .. 0.51
   2 !   28.1   0.1   2.1e-10   1.9e-06       7     107 ..     329     426 ..     323     429 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.61
                 HHHHSEEEC-CGGGHHHHHHHHHHH CS
         BTB  70 fiYtgeleitseenleelLaaadll 94 
                 ++++  +e+      e+lL+  ++l
  EFC38299.1 179 VMFPTFFENV--FLNEKLLSQLSKL 201
                 5544444333..1122333333333 PP

  == domain 2  score: 28.1 bits;  conditional E-value: 2.1e-10
                 HTTTS-EEEEETT...TEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHS.EEEC-CGGGHHHHHHHHHHHT-HHHHH CS
         BTB   7 sgelcDvtlvvgd...gkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtg.eleitseenleelLaaadllqiprlkk 101
                 +++  D+ +  +d     ++k+hk +L++ S +F+a ++s+    ++  + + +++ p +   ++e+iY + +lei+   nl ++++ a+   +++l++
  EFC38299.1 329 CDSDIDISITSEDgltSFTVKCHKTILMSKSLFFEAFLSSE----NG--TWNSSEIFPYETLFIIEYIYGKeHLEIP-NRNLLNVMKKAHEHGLNDLIE 420
                 55778999999998887899*******************99....33..4677899999999*******75269998.9******************** PP

                 HHHHHH CS
         BTB 102 aceefl 107
                  c+e++
  EFC38299.1 421 YCTEKV 426
                 **9976 PP

>> LPAM_1  Prokaryotic membrane lipoprotein lipid attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   1.2   5.8e-07    0.0052       1      17 [.       1      17 [.       1      17 [. 0.99
   2 ?   -1.7   0.2      0.56   5.1e+03       1       6 [.     254     259 ..     254     259 .. 0.90
   3 ?   -2.2   0.2      0.81   7.3e+03       1       7 [.     356     362 ..     356     362 .. 0.91

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 5.8e-07
      LPAM_1  1 MKKillalgalllLsGC 17
                M K+++al+a+llL++C
  EFC38299.1  1 MNKFIIALVATLLLASC 17
                9**************** PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.56
      LPAM_1   1 MKKill 6  
                 +KKil+
  EFC38299.1 254 WKKILF 259
                 8***98 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.81
      LPAM_1   1 MKKilla 7  
                 M K+l++
  EFC38299.1 356 MSKSLFF 362
                 99***97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (471 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       771  (0.043003); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.37s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 2558.40
//
Query:       EFC38300.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-84  283.1   0.0    1.9e-84  282.8   0.0    1.1  1  Cytochrom_C1     Cytochrome C1 family
     0.0017   19.5   0.0      0.004   18.3   0.0    1.7  1  Cytochrom_C      Cytochrome c
     0.0019   18.5   0.0      0.006   16.9   0.0    1.9  1  Cytochrome_CBB3  Cytochrome C oxidase, cbb3-type, subunit III


Domain annotation for each model (and alignments):
>> Cytochrom_C1  Cytochrome C1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  282.8   0.0   3.1e-88   1.9e-84       1     218 [.      34     250 ..      34     251 .. 0.99

  Alignments for each domain:
  == domain 1  score: 282.8 bits;  conditional E-value: 3.1e-88
  Cytochrom_C1   1 wsfegifgkfDkaqlqRGlqvykevcsaCHslklvafrnLaelglteeevkalaaeyevkdgpddegemfeRpgkpaDklpspyaneeaaraangga 97 
                   w ++++ g+fD a+++RG++vy+e+csaCH+++ +afrnL+ +++t++e+k laa ++v+ +pd +ge ++R++k  D+++spy+ne+aar++ngga
    EFC38300.1  34 WPHKELAGSFDAASIRRGYKVYREICSACHGMNEIAFRNLN-VAFTDAEIKVLAAAVDVEGEPDSQGEPTTRKAKAFDYMQSPYKNEQAARSMNGGA 129
                   99**************************************7.69***************************************************** PP

  Cytochrom_C1  98 lppDLsllvkArkggadYiyslLtgYeeppagvevkegqyyNkyfpggviamakpLsdgqveyedgtpatveqmakDvtaFLaWaaepklearkklg 194
                   lppDLs++vk+r + +dYi+slLtgYe++pagv+++eg+y+N yfpgg+i ma+pLsdg++e++dgtpa+v+qmakDv+++L+++a p +e rkk+g
    EFC38300.1 130 LPPDLSVIVKGRPHNEDYIFSLLTGYEDAPAGVSLREGLYWNAYFPGGAIGMAPPLSDGAIEFDDGTPASVSQMAKDVSTYLTYCAAPDTEPRKKMG 226
                   ************************************************************************************************* PP

  Cytochrom_C1 195 lkvilfllilavllylvkrkiwak 218
                   lkv++ l+++ +l+++ kr +w++
    EFC38300.1 227 LKVLASLSLVIALSWVHKRFKWST 250
                   **********************86 PP

>> Cytochrom_C  Cytochrome c
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   6.6e-07     0.004       2      81 ..      49     122 ..      48     135 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 6.6e-07
                  --HHHHHHTTGGGTB-SSSBSSS....--HHHHHHHTTT-HHHHHHH.HTTSS--SSSHHHHHHHGGGGGGG.TT--HHHH CS
  Cytochrom_C   2 arGkelftanCaaCHgvegggakqgggptlsgaaerasaasigasva.npaavsaprddfekkkltaemparkerlteqei 81 
                   rG++++ + C aCHg+++ +      ++l  a + a  + + a v+ +++ +s++ ++  k+k++  m+ +    +eq++
   EFC38300.1  49 RRGYKVYREICSACHGMNEIAF-----RNLNVAFTDAEIKVLAAAVDvEGEPDSQGEPTTRKAKAFDYMQSP--YKNEQAA 122
                  69*****99**********998.....677777777777766666651455566666666666655555555..5555555 PP

>> Cytochrome_CBB3  Cytochrome C oxidase, cbb3-type, subunit III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0     1e-06     0.006       2      22 ..      47      67 ..      46     114 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 1e-06
  Cytochrome_CBB3  2 aaaaGaalykknCasCHgkgg 22
                      +++G ++y++ C++CHg + 
       EFC38300.1 47 SIRRGYKVYREICSACHGMNE 67
                     689***************443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       479  (0.0267165); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1491.11
//
Query:       EFC38301.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.2e-39  133.4   0.0    8.6e-39  133.1   0.0    1.0  1  polyprenyl_synt  Polyprenyl synthetase


Domain annotation for each model (and alignments):
>> polyprenyl_synt  Polyprenyl synthetase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.1   0.0   4.8e-43   8.6e-39       7     175 ..      21     191 ..      16     201 .. 0.89

  Alignments for each domain:
  == domain 1  score: 133.1 bits;  conditional E-value: 4.8e-43
                      HHHHHHH.SSS--HHHHHHHHHHHHHSCGHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-SEETTEE-HHHCTCHHHHHHHHHHHHHHHHHHHH CS
  polyprenyl_synt   7 aleylve.agGKrlRpllvllaaealkeeeeelekaavlawivellhaasLvhDDimDdsetRRGqpcahrlvGnklAindgdfllarafella 99 
                      +++yl++  +GK +R+ l+ +++e++k +e   +++ v+  i+  lh+asL++DDi D+s++RRG+pcah ++G++++in ++++++ a++ ++
       EFC38301.1  21 PYSYLINnTNGKGFRSKLIDAFNEWFKLSE---DELNVIKSIIDKLHNASLLVDDIEDNSKLRRGKPCAHLIYGTPATINCANYVYFEALKDIQ 111
                      5566665379*****************777...6889********************************************************* PP

                      HHH.....STT.HHHHHHHHHHHHHHHHHHHHHHHHTTTTTCCC.SHHHHHHHHHHHTHHHCHHHHHHHHHHTTHHHHHHHH CS
  polyprenyl_synt 100 klf.....eks.lellelfsevllqtveGqlldleeekdddlskfsleeyleivkyKTaylfalpvalaallagasdeelea 175
                      kl+     ++s  e++ +f ++ll ++eGq++d++++  d+  ++s+++yl +v++KT++lf+l v l+ + +  +d++  +
       EFC38301.1 112 KLNssfsdQQSfSEAITVFMDELLLLHEGQGCDIYWR--DNGICPSEQDYLVMVQNKTGGLFRLGVGLMKASSTQKDSKTYD 191
                      999999975668************************9..677789************************9999976654444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       583  (0.0325172); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1494.26
//
Query:       EFC38302.1  [L=350]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-40  132.9  29.5    0.00036   20.3   0.2   12.3 12  LRR_6     Leucine Rich repeat
    1.8e-28   98.1  36.1    2.5e-09   36.7   0.5    5.9  7  LRR_8     Leucine rich repeat
    1.5e-26   92.0  26.5    0.00043   20.6   0.3    8.3 11  LRR_4     Leucine Rich repeats (2 copies)
    4.9e-12   44.6  13.3        9.1    7.3   0.0   10.5 11  LRR_1     Leucine Rich Repeat
    6.7e-05   22.5   9.4       0.24   10.9   0.2    3.8  5  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
      0.071   13.2   0.0        1.5    9.0   0.0    2.7  3  VirE_N    VirE N-terminal domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.12   3.5e+02       5      18 ..       4      17 ..       3      22 .. 0.89
   2 !   12.2   0.0   4.8e-05      0.14       3      23 ..      26      46 ..      24      47 .. 0.88
   3 !   12.8   0.1   3.1e-05     0.093       4      22 ..      51      69 ..      48      70 .. 0.90
   4 !   17.3   0.1   1.2e-06    0.0035       5      23 ..      76      94 ..      73      94 .. 0.94
   5 !   16.7   0.0   1.8e-06    0.0054       3      24 .]      98     119 ..      96     119 .. 0.92
   6 !    9.9   0.1   0.00027       0.8       3      24 .]     122     143 ..     120     143 .. 0.92
   7 !   15.7   0.1   3.7e-06     0.011       5      24 .]     173     192 ..     169     192 .. 0.89
   8 !   20.3   0.2   1.2e-07   0.00036       3      24 .]     219     240 ..     217     240 .. 0.93
   9 ?    3.2   0.0     0.039   1.2e+02      15      24 .]     255     264 ..     254     264 .. 0.91
  10 !   14.3   0.0     1e-05     0.031       4      24 .]     268     288 ..     265     288 .. 0.93
  11 !   15.4   0.0   4.7e-06     0.014       3      24 .]     291     312 ..     289     312 .. 0.92
  12 ?    4.8   0.1     0.011        34       3      17 ..     315     329 ..     313     330 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.12
       LRR_6  5 LteLdLsgNdIgDe 18
                L++LdL +N I+ e
  EFC38302.1  4 LKKLDLISNVISSE 17
                99*******99876 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 4.8e-05
       LRR_6  3 thLteLdLsgNdIgDeGaeaL 23
                 +LteL++ +NdIg + +e L
  EFC38302.1 26 INLTELSIGYNDIGYKAVEYL 46
                58************9999877 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 3.1e-05
       LRR_6  4 hLteLdLsgNdIgDeGaea 22
                +Lt L++s ++I++ G+e+
  EFC38302.1 51 KLTILNISKCKITNLGIES 69
                7***************986 PP

  == domain 4  score: 17.3 bits;  conditional E-value: 1.2e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+L++s N+I+D+G+++L
  EFC38302.1 76 LTSLEISENGIDDSGVKSL 94
                9****************97 PP

  == domain 5  score: 16.7 bits;  conditional E-value: 1.8e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt+Ld+ +N+I  eG+++++
  EFC38302.1  98 SQLTKLDIDHNEIRTEGCKCIS 119
                 679****************996 PP

  == domain 6  score: 9.9 bits;  conditional E-value: 0.00027
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt L++  N+I+ eG++ ++
  EFC38302.1 122 KNLTDLSVGLNGIDEEGIKFIC 143
                 58****************9987 PP

  == domain 7  score: 15.7 bits;  conditional E-value: 3.7e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +L++ +N IgD+Ga+ ++
  EFC38302.1 173 LISLNIGDNWIGDAGAKVIS 192
                 779*************9875 PP

  == domain 8  score: 20.3 bits;  conditional E-value: 1.2e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 t+Lt Ld+s N++gDeGa+ ++
  EFC38302.1 219 TNLTFLDISANNLGDEGAKLIS 240
                 89*****************985 PP

  == domain 9  score: 3.2 bits;  conditional E-value: 0.039
       LRR_6  15 IgDeGaeaLa 24 
                 Ig+eGae+++
  EFC38302.1 255 IGNEGAESIS 264
                 9******996 PP

  == domain 10  score: 14.3 bits;  conditional E-value: 1e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +LteLd+  N I  eGa++L+
  EFC38302.1 268 KLTELDVHRNSIETEGAKSLS 288
                 8******************96 PP

  == domain 11  score: 15.4 bits;  conditional E-value: 4.7e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  hLt Ld+s N I D+G++ L+
  EFC38302.1 291 KHLTRLDISENFIEDSGVKYLS 312
                 6*****************9885 PP

  == domain 12  score: 4.8 bits;  conditional E-value: 0.011
       LRR_6   3 thLteLdLsgNdIgD 17 
                  +L++L++ +N+I++
  EFC38302.1 315 KKLKHLNVYDNGIDN 329
                 58***********86 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   1.1   1.3e-08   3.9e-05       2      61 .]       3      62 ..       2      62 .. 0.97
   2 !   36.7   0.5   8.5e-13   2.5e-09       2      61 .]      51     110 ..      50     110 .. 0.98
   3 !   12.9   0.4   2.4e-05      0.07       2      38 ..      99     135 ..      98     158 .. 0.72
   4 !   14.3   0.0   8.3e-06     0.025      18      61 .]     164     207 ..     146     207 .. 0.87
   5 !   25.0   0.1     4e-09   1.2e-05       2      61 .]     172     231 ..     171     231 .. 0.97
   6 !   20.0   1.4   1.4e-07   0.00042       2      61 .]     220     279 ..     219     279 .. 0.97
   7 !   31.3   0.4   4.1e-11   1.2e-07       2      61 .]     268     327 ..     267     327 .. 0.97

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 1.3e-08
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +L++LdL +N ++s   ++  +l nL++L++++N +     + +s L++L+ L++s +++
  EFC38302.1  3 QLKKLDLISNVISSEATQSIGNLINLTELSIGYNDIGYKAVEYLSKLEKLTILNISKCKI 62
                79******************************************************9986 PP

  == domain 2  score: 36.7 bits;  conditional E-value: 8.5e-13
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++s+ ++t+l+ e+  g+++L++L++s+N ++    +++  L++L++Ld+++N +
  EFC38302.1  51 KLTILNISKCKITNLGIESMIGMKQLTSLEISENGIDDSGVKSLIELSQLTKLDIDHNEI 110
                 79********************************************************87 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 2.4e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 +Lt+Ld+++N +   + ++ ++++nL+ L+ + N ++
  EFC38302.1  99 QLTKLDIDHNEIRTEGCKCISQMKNLTDLSVGLNGID 135
                 6788888888888888888888888888888877665 PP

  == domain 4  score: 14.3 bits;  conditional E-value: 8.3e-06
                 TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  18 deaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  ++ ++l++L +L++++N +    ++++s +++L+ L++ ++ +
  EFC38302.1 164 VQSITSLKQLISLNIGDNWIGDAGAKVISEMKQLKTLYMHSTLI 207
                 467889*********************************98765 PP

  == domain 5  score: 25.0 bits;  conditional E-value: 4e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L sL++ +N + + + ++ + +++Lk+L++ + l+     +++s +++L++Ld+s N+L
  EFC38302.1 172 QLISLNIGDNWIGDAGAKVISEMKQLKTLYMHSTLIGIDGTKSISEMTNLTFLDISANNL 231
                 5779******************************************************98 PP

  == domain 6  score: 20.0 bits;  conditional E-value: 1.4e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt Ld+s N+l + + +  +gl++L  L +s+ ++    ++++s L++L++Ld+ +N +
  EFC38302.1 220 NLTFLDISANNLGDEGAKLISGLNQLIKLWISEISIGNEGAESISKLEKLTELDVHRNSI 279
                 8999******************************************************86 PP

  == domain 7  score: 31.3 bits;  conditional E-value: 4.1e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+Ld+++N+++  + ++ ++l++L+ Ld+s+N ++    + +s +++L++L++ +N +
  EFC38302.1 268 KLTELDVHRNSIETEGAKSLSKLKHLTRLDISENFIEDSGVKYLSKMKKLKHLNVYDNGI 327
                 79****************************************************999875 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.8   2.4e-05     0.071       2      39 ..       3      38 ..       2      50 .. 0.85
   2 !   20.6   0.3   1.4e-07   0.00043       2      38 ..      51      88 ..      50      98 .. 0.87
   3 !   12.1   0.1   6.9e-05      0.21       2      35 ..      99     133 ..      92     139 .. 0.81
   4 ?    3.5   0.2     0.035   1.1e+02       1      30 [.     122     153 ..     122     170 .. 0.69
   5 !    7.0   0.0    0.0028       8.3       2      38 ..     147     185 ..     146     188 .. 0.67
   6 !   16.0   0.0   4.1e-06     0.012       1      36 [.     171     207 ..     171     214 .. 0.83
   7 !   16.5   0.2   2.8e-06    0.0085       1      36 [.     195     231 ..     195     240 .. 0.83
   8 !   12.4   1.0   5.6e-05      0.17       1      32 [.     219     252 ..     219     266 .. 0.84
   9 !   10.1   0.2    0.0003      0.89       3      39 ..     245     279 ..     243     291 .. 0.75
  10 !   20.1   0.1   2.1e-07   0.00064       2      38 ..     268     305 ..     267     307 .. 0.91
  11 !   20.5   0.2   1.6e-07   0.00048       1      36 [.     291     327 ..     291     335 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.4e-05
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39
                +L++LdL +N +++     +++l nL+eL++  N    d+
  EFC38302.1  3 QLKKLDLISNVISSEATqsIGNLINLTELSIGYN----DI 38
                69*******9***755566668*********888....76 PP

  == domain 2  score: 20.6 bits;  conditional E-value: 1.4e-07
                S--EEE--SS---E-S-HH..H-TT--EEE-.-S----- CS
       LRR_4  2 nLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitd 38
                +L++L++s +++t ++  +  ++++L++L +s+N  i+d
  EFC38302.1 51 KLTILNISKCKITNLGIESmiGMKQLTSLEISEN-GIDD 88
                8****************66667*********999.6644 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 6.9e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 +L++Ld+ +N +++ +   +++++nL+ L++ g n 
  EFC38302.1  99 QLTKLDIDHNEIRTEGCkcISQMKNLTDLSV-GLNG 133
                 79***********755576557********8.6334 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.035
                 SS--EEE--SS---E-S-...HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdL 30 
                 +nL+ L+ + N + + +    +  l++L+ L+ 
  EFC38302.1 122 KNLTDLSVGLNGIDEEGIkfiC-ELKQLTNLSA 153
                 6899999997799977777433.3888888875 PP

  == domain 5  score: 7.0 bits;  conditional E-value: 0.0028
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38 
                 +L++L+ +  q+ ++++   + +l++L +L++ g n i+d
  EFC38302.1 147 QLTNLSAHAIQIVSVDGvqsITSLKQLISLNI-GDNWIGD 185
                 67777777667777777443447888888999.5556655 PP

  == domain 6  score: 16.0 bits;  conditional E-value: 4.1e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L++++N + d +   ++ +++Lk+L++ + +li
  EFC38302.1 171 KQLISLNIGDNWIGDAGAkvISEMKQLKTLYM-HSTLI 207
                 589************99997556*********.54455 PP

  == domain 7  score: 16.5 bits;  conditional E-value: 2.8e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 ++L++L+ +++ +  i++   ++ ++nL+ Ld+s Nn +
  EFC38302.1 195 KQLKTLYMHSTLIG-IDGtksISEMTNLTFLDISANN-L 231
                 589*******7777.999875445*********9994.3 PP

  == domain 8  score: 12.4 bits;  conditional E-value: 5.6e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsg 32 
                 +nL++Ld+s N+l d +   +++l +L +L++s+
  EFC38302.1 219 TNLTFLDISANNLGDEGAklISGLNQLIKLWISE 252
                 7********88****99995446********976 PP

  == domain 9  score: 10.1 bits;  conditional E-value: 0.0003
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 L++L++s   +   +   ++kl +L+eLd+++N    ++
  EFC38302.1 245 LIKLWISEISIGNEGAesISKLEKLTELDVHRN----SI 279
                 888999985666444454558*********999....55 PP

  == domain 10  score: 20.1 bits;  conditional E-value: 2.1e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +L++Ld + N + + +   l+kl++L+ Ld+s+N +i+d
  EFC38302.1 268 KLTELDVHRNSIETEGAksLSKLKHLTRLDISEN-FIED 305
                 8************988899889*********999.8876 PP

  == domain 11  score: 20.5 bits;  conditional E-value: 1.6e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L+ Ld+s N + d +   l+k+++Lk+L++ +N  i
  EFC38302.1 291 KHLTRLDISENFIEDSGVkyLSKMKKLKHLNVYDN-GI 327
                 68*************88899999*********777.44 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.49   1.5e+03       1      12 [.       3      14 ..       3      25 .. 0.73
   2 ?    2.8   0.0     0.092   2.8e+02       1      12 [.      27      38 ..      27      49 .. 0.81
   3 !    6.7   0.0    0.0048        14       1      19 [.      51      69 ..      51      72 .. 0.87
   4 ?    0.9   0.0      0.37   1.1e+03       1      19 [.      75      93 ..      75      97 .. 0.78
   5 ?    4.3   0.1      0.03        89       1      18 [.      99     116 ..      99     135 .. 0.79
   6 ?    2.4   0.0      0.12   3.5e+02       2      14 ..     173     185 ..     172     194 .. 0.81
   7 ?   -2.5   0.0       5.1   1.5e+04       1       8 [.     196     203 ..     196     209 .. 0.79
   8 ?    5.6   0.1     0.011        33       1      22 [.     220     241 ..     220     266 .. 0.87
   9 !    7.3   0.0    0.0031       9.1       1      23 []     268     290 ..     268     290 .. 0.94
  10 !    6.4   0.0    0.0059        18       1      22 [.     292     313 ..     292     314 .. 0.84
  11 ?    4.8   0.0      0.02        60       1      12 [.     316     327 ..     316     337 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.49
       LRR_1  1 nLrhLdLsnnpl 12
                +L++LdL +n +
  EFC38302.1  3 QLKKLDLISNVI 14
                59****966655 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.092
       LRR_1  1 nLrhLdLsnnpl 12
                nL++L +++n +
  EFC38302.1 27 NLTELSIGYNDI 38
                8*********98 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0048
       LRR_1  1 nLrhLdLsnnpllglppns 19
                +L+ L++s + +++l+++s
  EFC38302.1 51 KLTILNISKCKITNLGIES 69
                79*********99887765 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.37
       LRR_1  1 nLrhLdLsnnpllglppns 19
                +L++L +s n +++ +  s
  EFC38302.1 75 QLTSLEISENGIDDSGVKS 93
                599*******997766665 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.03
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++Ld+ +n +   +  
  EFC38302.1  99 QLTKLDIDHNEIRTEGCK 116
                 599*******98544444 PP

  == domain 6  score: 2.4 bits;  conditional E-value: 0.12
       LRR_1   2 LrhLdLsnnpllg 14 
                 L +L++++n +++
  EFC38302.1 173 LISLNIGDNWIGD 185
                 899******9854 PP

  == domain 7  score: -2.5 bits;  conditional E-value: 5.1
       LRR_1   1 nLrhLdLs 8  
                 +L++L++ 
  EFC38302.1 196 QLKTLYMH 203
                 599**984 PP

  == domain 8  score: 5.6 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL+ Ld+s n+l++ ++  +++
  EFC38302.1 220 NLTFLDISANNLGDEGAKLISG 241
                 8**********98777766655 PP

  == domain 9  score: 7.3 bits;  conditional E-value: 0.0031
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++Ld+ +n+++  ++ s+++L
  EFC38302.1 268 KLTELDVHRNSIETEGAKSLSKL 290
                 79**************9999987 PP

  == domain 10  score: 6.4 bits;  conditional E-value: 0.0059
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++Ld+s n++++ +  ++++
  EFC38302.1 292 HLTRLDISENFIEDSGVKYLSK 313
                 69**********9888777765 PP

  == domain 11  score: 4.8 bits;  conditional E-value: 0.02
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+hL++ +n +
  EFC38302.1 316 KLKHLNVYDNGI 327
                 7******99987 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.3    0.0037        11      64     127 ..       2      64 ..       1      67 [. 0.84
   2 !    8.9   0.9   0.00033      0.99      47     126 ..      33     111 ..      18     129 .. 0.82
   3 !    5.9   0.3    0.0027       8.1      34     120 ..      62     153 ..      59     161 .. 0.76
   4 !    4.6   0.0    0.0067        20      58     124 ..     165     230 ..     147     253 .. 0.69
   5 !   10.9   0.2   8.1e-05      0.24      60     140 ..     263     342 ..     241     347 .. 0.89

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0037
       LRR_9  64 krlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                  +lk l l +n i   a +    l nl+el +  n +     ++ l +l+kl++l + k+ +tn
  EFC38302.1   2 DQLKKLDLISNVISSEATQSIGNLINLTELSIGYNDIGYK-AVEYLSKLEKLTILNISKCKITN 64 
                 6789999999999887777777788999999999999865.56999999***999999999887 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00033
       LRR_9  47 idlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 i  +d   + ++ +  l++l +l +++ +i++++ +    + +l++l +++n +++ + ++ l++l++l+ l + +n + 
  EFC38302.1  33 IGYNDIGYKAVEYLSKLEKLTILNISKCKITNLGIESMIGMKQLTSLEISENGIDDSG-VKSLIELSQLTKLDIDHNEIR 111
                 4455556678888888999999999999999888877778899999999999999965.699999999999998888765 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0027
       LRR_9  34 ienlGa....tldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsl 120
                 i+nlG      + q+ ++++s+n i +  + ++  l +l  l ++ n i+  + +    + nl+ l +  n ++e + ++ + +lk+l++ls 
  EFC38302.1  62 ITNLGIesmiGMKQLTSLEISENGIDDsgVKSLIELSQLTKLDIDHNEIRTEGCKCISQMKNLTDLSVGLNGIDEEG-IKFICELKQLTNLSA 153
                 56666422224678899999999887533778888999999999999999999999999999999999999998854.688888888888875 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.0067
       LRR_9  58 dgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                 +++  lk+l +l + +n i   + ++   + +l++l + +  +   ++ + + ++ +l++l +  n 
  EFC38302.1 165 QSITSLKQLISLNIGDNWIGDAGAKVISEMKQLKTLYMHSTLIGIDGT-KSISEMTNLTFLDISANN 230
                 344556677777788888888888888888888888877666554333.666666666666665554 PP

  == domain 5  score: 10.9 bits;  conditional E-value: 8.1e-05
       LRR_9  60 fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklk 140
                 +  l++l  l +  n i   + +    l +l+ l +++n +++ + ++ l ++kkl+ l + +n + n ++y +++  +lk
  EFC38302.1 263 ISKLEKLTELDVHRNSIETEGAKSLSKLKHLTRLDISENFIEDSG-VKYLSKMKKLKHLNVYDNGIDNGNKYLKRMKKQLK 342
                 56788999999999999999988889999************9966.69************************999988777 PP

>> VirE_N  VirE N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.0   0.00049       1.5      20      79 ..      90     149 ..      84     168 .. 0.91
   2 ?    0.9   0.0      0.16   4.7e+02       4      72 ..     195     263 ..     192     294 .. 0.72
   3 ?   -2.1   0.0       1.3     4e+03      23      55 ..     313     345 ..     304     347 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00049
      VirE_N  20 kekklkkynglvvlDidhlaskeeaeelrrllkedpqtllaFvspsgrGvKifvrierpd 79 
                 + k+l ++++l  lDidh + + e  ++  ++k++  + +   ++ ++G+K+++ +++ +
  EFC38302.1  90 GVKSLIELSQLTKLDIDHNEIRTEGCKCISQMKNLTDLSVGLNGIDEEGIKFICELKQLT 149
                 6788999**************99*******************************998765 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.16
      VirE_N   4 kklpavtpaaefsggrkekklkkynglvvlDidhlaskeeaeelrrllkedpqtllaFvspsgrGvKif 72 
                 k+l  +++  +  g  + k++ +++ l  lDi   +  +e ++l   l+++ ++ ++ +s+ ++G   +
  EFC38302.1 195 KQLKTLYMHSTLIGIDGTKSISEMTNLTFLDISANNLGDEGAKLISGLNQLIKLWISEISIGNEGAESI 263
                 567777777777777888899999999999986655556777777777777777777777766666555 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.3
      VirE_N  23 klkkynglvvlDidhlaskeeaeelrrllkedp 55 
                 k+kk+ +l v+D    ++ + +++++++lk+ +
  EFC38302.1 313 KMKKLKHLNVYDNGIDNGNKYLKRMKKQLKKKN 345
                 667777777777544455578888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.55
# Mc/sec: 1928.40
//
Query:       EFC38303.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   2.1e-100  336.1   0.2   2.4e-100  335.8   0.2    1.0  1  DUF4419   Domain of unknown function (DUF4419)
     0.0086   15.4   0.0      0.017   14.4   0.0    1.4  1  YmdB      YmdB-like protein


Domain annotation for each model (and alignments):
>> DUF4419  Domain of unknown function (DUF4419)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  335.8   0.2  2.7e-104  2.4e-100       1     302 []      55     344 ..      55     344 .. 0.96

  Alignments for each domain:
  == domain 1  score: 335.8 bits;  conditional E-value: 2.7e-104
     DUF4419   1 ngfveavleAyaehlhLvlrPDdvWlaIltqlsfyvnanaeelrslfvahegkkelevkaeekle..dweelakelteeiqknvkdpslrdwilpdFsT 97 
                 n+f+++++ Ay+eh++Lv+rPDdvW+aI+tq+++yvn+++eelrs+fv+++gkkel+v   ++l   d+ +l+ ++te+i+kn+kdps+rdwi+pdFsT
  EFC38303.1  55 NSFIHSAILAYSEHHNLVIRPDDVWIAIATQFANYVNSKSEELRSKFVDFDGKKELVVVGGGTLFtaDCADLTLRMTEQIAKNIKDPSVRDWIMPDFST 153
                 8*********************************************************888887799******************************** PP

     DUF4419  98 ttetdkvvaavllmatlkkyfeykvsllCGiPsvtLlGekeDWekllerlekLkefg...eelkewaklLrpildrfvesfdepdseenkeFWnkivke 193
                 tt+ +k+v av+lm+t+k+yf+yk+ l+CG+PsvtLlGekeDW++l er+++L ef+   + +k+w+++L p+l++fv+s++  +++ ++++Wn+i++ 
  EFC38303.1 154 TTNLEKMVGAVVLMSTTKNYFDYKYVLRCGLPSVTLLGEKEDWQNLYERAKRLIEFDtkaKLMKKWSDMLLPVLEQFVKSAS--GNP-DTKWWNRIAHV 249
                 ********************************************************655699********************..556.689******** PP

     DUF4419 194 eseegsgeselsGWitaFcvydkdgkvleeekkeeeeeeseeeealvldgveypeidtddipsglasvpvkldedngkeyelelvaGsvGvkvsseeed 292
                  ++ gsg++++sGWi  F  +++ g + ++ k+ ++ +             e+p +d++di++g++svpv++d dng+ y++el+aG++  + +++++d
  EFC38303.1 250 FGG-GSGPTYISGWIGVFSAFSDAGVWRGDVKSAKDVK------------SEWPIMDMQDISRGYVSVPVTVD-DNGTIYKTELYAGHMCARLHNNSND 334
                 **9.9************************988777554............35********************9.999********************** PP

     DUF4419 293 tlqpvsgWal 302
                  + p ++Wal
  EFC38303.1 335 SIIPRVDWAL 344
                 ********96 PP

>> YmdB  YmdB-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0   1.9e-06     0.017      57     158 ..      47     161 ..      36     171 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.9e-06
        YmdB  57 vdviTlGnhvwdkkeilelieeeerllrP...........aNyp.egapGkglvvvevkgkkvaVinllGrvfmeekldnpFeaadelleklek.ekad 142
                  d++T+Gn ++ ++ il + e+++ ++rP           aNy  ++ +   +++v+ +gkk +V+   G++f  + +d   ++++++ +++++ +  d
  EFC38303.1  47 PDFLTVGNNSFIHSAILAYSEHHNLVIRPddvwiaiatqfANYVnSKSEELRSKFVDFDGKKELVVVGGGTLFTADCADLTLRMTEQIAKNIKDpSVRD 145
                 599**************************6666555555556641345556677788888899999999999999989999********9996656679 PP

        YmdB 143 iiivDfhAeaTsEKia 158
                  i+ Df   +  EK++
  EFC38303.1 146 WIMPDFSTTTNLEKMV 161
                 9999**9999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       425  (0.0237046); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.36s 00:00:00.98 Elapsed: 00:00:00.56
# Mc/sec: 1881.27
//
Query:       EFC38304.1  [L=914]
Description: SET domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.2e-12   46.0   3.5    9.8e-12   45.6   1.2    2.5  2  SET       SET domain
      9e-05   22.5  11.9      9e-05   22.5  11.9    2.3  2  zf-MYND   MYND finger
  ------ inclusion threshold ------
      0.043   14.0   0.0          1    9.7   0.0    2.7  2  TPR_2     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> SET  SET domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.8   1.1e+04      64      88 ..      62      86 ..      21     133 .. 0.60
   2 !   45.6   1.2   1.6e-15   9.8e-12       1     168 [.     288     512 ..     288     513 .. 0.56

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.8
                HHHHHHHHHHHHHHHHHHTHHHHHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxx RF
         SET 64 lqklakdqkqaekedtdaalkassk 88
                 +k+ k+  ++e+e td  lk+  +
  EFC38304.1 62 QSKAMKTMIKEEEETTDLTLKRVNQ 86
                3333334444444444444444333 PP

  == domain 2  score: 45.6 bits;  conditional E-value: 1.6e-15
                 SCEEEESSXBXTTXEEEEEEECCEECHHHHHHHHHH................................HTEEEEEXGGXXGGSXHHHHHHHTTSSHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         SET   1 GrGvfAtedIpkgeficeypeeiiltkdeadksele................................aylfslpeapknlaftkelakasastllqkl 67 
                 GrG++A+ +++ g+++  + e+++l+ + + ++ ++                                                               
  EFC38304.1 288 GRGMYASSELKSGQVV--LSEKPFLCVTLDTENTCNnclnklkkkipcknncgmeyycsmecrseawdK------------------------------ 354
                 9***************..787778888888888877566666666666666666554444433333331.............................. PP

                 HHHHHHHHHHHHHHTHHHHHHHXTTTS...........X.............................................XXHCCCCCHCCCHEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx...........x.............................................xxxxxxxxxxxxxxx RF
         SET  68 akdqkqaekedtdaalkasskaesdln...........a.............................................skpeagafsaiagys 110
                    ++++  +d ++ +k++++   + +           +                                                            
  EFC38304.1 355 --YHRKLCGFDMRNINKMIVSGSTNSAknhlyaikflgMllqivypqgelkqqeiryvqfiekleennssfkcliawpnilndlI-------------- 437
                 ..33444444455555554444333332333333333314444444444444444444444443222222333333333333330.............. PP

                 EE............TEEEEEECCC..........GTTGGGCEEXSSSSEEEEEEEETTSSEEEEEESSXBXTTEEEEEXT CS
                 xx............xxxxxxxxxx..........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         SET 111 id............aralksgnga..........gplarflNHsCdpNcnltvqnvlrgprvavfAtrdIkkGeEltidY 168
                                +++k+g+++             + + NHsC pN++++++    +++  ++A+r+IkkGe+l+i+Y
  EFC38304.1 438 -GklsyhvsldkigNNSFKYGDAMsngvalsstlPKTIVYTNHSCVPNVEYRYE----NGKCSLVALRKIKKGEQLFISY 512
                 .03333322333334444444444555566666655889**********55555....5********************* PP

>> zf-MYND  MYND finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5  11.9   1.5e-08     9e-05       1      38 []     320     360 ..     320     360 .. 0.91
   2 ?   -2.6   1.4         1   6.1e+03       1       6 [.     535     540 ..     533     577 .. 0.54

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 1.5e-08
                 -TTT--.B-SC.E-.TTTS-SEESSHHHHHHCH.HHHCCCH CS
     zf-MYND   1 CavCgkaealk.kC.agCksvfYCskeCqradw.ksHkteC 38 
                 C++C ++ ++k +C  +C   +YCs eC++++w k+H++ C
  EFC38304.1 320 CNNCLNKLKKKiPCkNNCGMEYYCSMECRSEAWdKYHRKLC 360
                 ******55555***668**********************99 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1
                 -TTT-- CS
     zf-MYND   1 CavCgk 6  
                 C++C+k
  EFC38304.1 535 CEKCEK 540
                 444444 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0   0.00017         1       4      30 ..      30      56 ..      28      57 .. 0.93
   2 ?    1.0   0.0       0.1     6e+02       3      21 ..     134     152 ..     133     154 .. 0.90

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00017
       TPR_2  4 lynlGlayyklgdyeeAleafekAlel 30
                 +  G+ ++++g + eA e  ekA+++
  EFC38304.1 30 FFTKGNTLFESGSFPEAYEEIEKAIQI 56
                5889*********************97 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.1
       TPR_2   3 alynlGlayyklgdyeeAl 21 
                 al+++++++++lg ++ Al
  EFC38304.1 134 ALNCRAKILIALGYPAMAL 152
                 799**********999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (914 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1346  (0.0750739); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.80u 0.32s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 5235.85
//
Query:       EFC38305.1  [L=1075]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0046   17.2  19.5     0.0046   17.2  19.5   12.6 13  TMF_TATA_bd   TATA element modulatory factor 1 TATA binding
  ------ inclusion threshold ------
      0.012   14.5 199.5      0.037   12.9  16.3    8.4  9  Spc7          Spc7 kinetochore protein
        1.3    8.5 177.1      0.041   13.4  57.2    4.9  4  Filament      Intermediate filament protein


Domain annotation for each model (and alignments):
>> TMF_TATA_bd  TATA element modulatory factor 1 TATA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   2.7      0.05     3e+02      64     114 ..     169     219 ..     156     220 .. 0.62
   2 !    5.9   7.9    0.0024        14      59     106 ..     240     287 ..     229     296 .. 0.89
   3 ?   -2.6  11.6         1   6.1e+03      16      82 ..     309     376 ..     288     377 .. 0.59
   4 ?    3.6  18.5     0.012        75      15     109 ..     361     456 ..     350     460 .. 0.90
   5 ?    3.8   8.4     0.011        66      25      93 ..     459     528 ..     453     532 .. 0.78
   6 ?    2.1  14.9     0.037   2.2e+02      30     103 ..     514     584 ..     502     596 .. 0.60
   7 ?   -0.4  11.2      0.21   1.3e+03      24      78 ..     578     632 ..     565     634 .. 0.54
   8 !    8.8  23.3    0.0003       1.8      15     115 .]     621     726 ..     612     726 .. 0.85
   9 ?    3.2  10.3     0.017     1e+02      25      93 ..     720     787 ..     719     797 .. 0.86
  10 !   17.2  19.5   7.7e-07    0.0046      26     109 ..     798     881 ..     787     887 .. 0.89
  11 ?    0.6   5.6      0.11   6.6e+02      25      77 ..     891     942 ..     876     947 .. 0.53
  12 !    7.1   9.3     0.001       6.1      20      82 ..     923     985 ..     921     990 .. 0.93
  13 ?    1.2   1.5     0.069   4.1e+02      19      70 ..    1024    1071 ..     998    1075 .] 0.73

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.05
  TMF_TATA_bd  64 keleelekeleelqeryetlLellGeksEeveELraDvaDlKemykeqveq 114
                  k  +  e+ + +l++  e++   l + s e ++L++  +D+++ y eq+++
   EFC38305.1 169 KLKQAYETIIFKLKSNNESVKSKLLKVSKEFKDLKKNQVDIRTEYLEQIQK 219
                  223333334445666666666666677777888888888888888888875 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0024
  TMF_TATA_bd  59 lkelkkeleelekeleelqeryetlLellGeksEeveELraDvaDlKe 106
                   +e +k ++e +++l+e  ++ etl + l   +E+ ++L++D++ l++
   EFC38305.1 240 IEERNKIVTEFKSQLNEKMHQMETLQTSLNVTTEREKQLKQDLENLRD 287
                  577889999************************************997 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1
  TMF_TATA_bd  16 rlsseirrlEgElaslkeelerleaerdeareeivklmke.neelkelkkeleelekeleelqeryet 82 
                  +ls +  +l + ++++ ++l +  ++  ++++ei +l++  n+++ +++k+++++++ ++e +e+ye+
   EFC38305.1 309 QLSISESELKVSIHEISQDLHSEREKSLKLTSEIDRLTNIvNQNQIDMNKSSNDVQQMVKESEEKYEK 376
                  33333333333344444444444444445667777777541444557788888888899999999886 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.012
  TMF_TATA_bd  15 erlsseirrlEgElaslkeelerleaerdeareeivklmkeneelkelkkeleel.ekeleelqeryetlLellGeksEeveELraDvaDlKemyk 109
                  +  ++ +++ E  ++++ ++ ++l++  +e ++ i++l++e ++ +e+ ++l++l e+++ + +++ e+l   l e + + eE  ++++Dl+ ++ 
   EFC38305.1 361 NDVQQMVKESEEKYEKISSQFAELQSTLSERSNTILDLTNELHSENETVANLKKLiESNYMSSEKQIEELKLALNEHKNQLEERIKELEDLRSIIT 456
                  678999**********************************999999999988886478999999999*************************9876 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.011
  TMF_TATA_bd  25 EgElaslkeelerleaerdeareeivklmke.neelkelkkeleelekeleelqeryetlLellGeksEe 93 
                  +  +++  ++++ l+++++++++ + k+ ++ + + ++l  e+++le+e + l++ y+++Le +++ ++e
   EFC38305.1 459 DEVITTKDDQISHLTQKKNNVESLLEKMKHDaSSNHETLVVENNKLEEEKNRLDNNYQQALETIKKIQDE 528
                  5556677789999999999998877777654145667788999*******************99987665 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.037
  TMF_TATA_bd  30 slkeelerleaerdeareeivklmkeneelkelkkeleelekeleelqeryetlLellGeksEeveELraDvaD 103
                  ++++ le++++ +de+r+   ++++   +l++++ke ++l++++++lqe+ e + + l+e +    +L + + D
   EFC38305.1 514 NYQQALETIKKIQDELRNSNETVISLQLQLEAKQKEHSSLNSKFNDLQEKFEDVSKTLQETK---SDLTQQLTD 584
                  34555566666666666666666666677777778888888888888888888888887643...333333333 PP

  == domain 7  score: -0.4 bits;  conditional E-value: 0.21
  TMF_TATA_bd  24 lEgElaslkeelerleaerdeareeivklmkeneelkelkkeleelekeleelqe 78 
                  l  +l+  ++ l++l ++ d++++e+++  ke e++ +l++e+++l+++l+  ++
   EFC38305.1 578 LTQQLTDKESLLKTLLQKTDDMTKELAEYNKEKEAQITLEEESKKLNEKLNTTNQ 632
                  3334444444555556666666666666666666666666666666666655554 PP

  == domain 8  score: 8.8 bits;  conditional E-value: 0.0003
  TMF_TATA_bd  15 erlsseirrlEgElaslkeelerleaerdeareeivklm....keneelkelkkeleelekel.eelqeryetlLellGeksEeveELraDvaDlKem 107
                  ++l+ ++     El++lkeel++ ++ rd++r+e+ + +    + n+++++l +e ++l ++l +e++++ +   +ll   +  + E r +++ lKe+
   EFC38305.1 621 KKLNEKLNTTNQELSKLKEELQNTTQDRDSTRSELENTLkivyNLNNTVNSLTEEKDNLHEQLhTEMENKSQLENTLLSNLDKTTLEQRSEIQKLKEI 718
                  57999999**************************987663334778888888888888877652578888888888888888899************* PP

  TMF_TATA_bd 108 ykeqveql 115
                  y++ +++l
   EFC38305.1 719 YESEIKKL 726
                  ***99976 PP

  == domain 9  score: 3.2 bits;  conditional E-value: 0.017
  TMF_TATA_bd  25 EgElaslkeele.rleaerdeareeivklmkeneelkelkkeleelekeleelqeryetlLellGeksEe 93 
                  E+E+++l+e  + ++ +++++ + ++ +l ++ e+  e+    ++ + e+  ++e  et L +l+eksEe
   EFC38305.1 720 ESEIKKLQEASKtEIINQKEKYEFDLNELKTRYEREMES--VKKSYQDEIGVMKESCETELNILKEKSEE 787
                  8999999998752799*************9999975555..5578899********************97 PP

  == domain 10  score: 17.2 bits;  conditional E-value: 7.7e-07
  TMF_TATA_bd  26 gElaslkeelerleaerdeareeivklmkeneelkelkkeleelekeleelqeryetlLellGeksEeveELraDvaDlKemyk 109
                  ++ +++k+  e l +++d++++ei + ++   el++l+k+ ++leke +e ++ +e++L+ l+ek+ e +E + D  Dl + +k
   EFC38305.1 798 NQSSKIKQLSEDLRKSKDSIEKEISRRSSIEKELHDLQKQHKSLEKESQEKKDTLEKSLKTLKEKEAELKEIKRDAIDLSKKCK 881
                  455677788888999***************************************************************987766 PP

  == domain 11  score: 0.6 bits;  conditional E-value: 0.11
  TMF_TATA_bd  25 EgElaslkeelerleae..rdeareeivklmkeneelkelkkeleelekeleelq 77 
                  + E+ +lk+ele+ +     ++a++e      +ne +k+l+ke e+le++++el+
   EFC38305.1 891 DKEIIKLKKELEKKTIAllEKTAKQEP---AIDNELVKRLQKEKETLEQQVKELT 942
                  444444444444333220022222222...2356777777777777777777765 PP

  == domain 12  score: 7.1 bits;  conditional E-value: 0.001
  TMF_TATA_bd  20 eirrlEgElaslkeelerleaerdeareeivklmkeneelkelkkeleelekeleelqeryet 82 
                   ++rl+ E+++l++++++l++   + +   ++++   +el+  k+e+++l+++l+elq++ ++
   EFC38305.1 923 LVKRLQKEKETLEQQVKELTEAPAASETPSIEVSMMKNELEMGKAEISDLREKLNELQQEKKK 985
                  699*******************************************************98765 PP

  == domain 13  score: 1.2 bits;  conditional E-value: 0.069
  TMF_TATA_bd   19 seirrlEgElaslkeelerleaerdeareeivklmkeneelkelkkeleele 70  
                   ++ + lE El+  k  + ++++++d+++    k +k  e  ke+k+++++l+
   EFC38305.1 1024 KTCKLLEQELELWKCAVPSVKQQKDTVS----KFTKCEEIIKEMKSSIKQLR 1071
                   5667788888888888888888887654....56666666666666666665 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  20.8   0.00013       0.8     135     262 ..     165     294 ..     163     310 .. 0.87
   2 ?   11.5  26.7   1.6e-05     0.097     143     291 ..     302     450 ..     298     463 .. 0.89
   3 ?    3.9   5.0    0.0033        20     198     242 ..     445     489 ..     434     498 .. 0.43
   4 ?    9.0  26.2   9.5e-05      0.57     162     278 ..     480     599 ..     465     604 .. 0.62
   5 ?   -0.8  34.2     0.095   5.7e+02     143     275 ..     598     730 ..     582     738 .. 0.66
   6 ?   -1.5  21.7      0.15   8.7e+02     173     281 ..     739     844 ..     728     845 .. 0.63
   7 ?    4.3  19.6    0.0026        16     156     240 ..     829     912 ..     825     920 .. 0.88
   8 ?   12.9  16.3   6.1e-06     0.037     160     261 ..     914    1016 ..     909    1035 .. 0.79
   9 ?   -2.1   1.8      0.23   1.4e+03     225     253 ..    1043    1070 ..    1011    1075 .] 0.37

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00013
        Spc7 135 qllegLkegleenlegleedkelLekqeeeldellpeleeekaeleee.leklqeaaeelesidkeeLeelreelaelkae.ieekkkelaelqeqlee 231
                 q +e+Lk+ +e ++ +l++ +e ++++  ++++  ++l++++ +++ e le++q+    l s +++e+ ++ + l e  ++ + e+k +l+e+  q+e+
  EFC38305.1 165 QEIEKLKQAYETIIFKLKSNNESVKSKLLKVSKEFKDLKKNQVDIRTEyLEQIQKTGSTLGSFTSTEIGKISSHLIEERNKiVTEFKSQLNEKMHQMET 263
                 7799*****************************************98846888889999999********9998766555516899************* PP

        Spc7 232 leekieelkeqkseleeeiaeaervleeckg 262
                 l+++++ ++e+ ++l++++++ ++  e++k+
  EFC38305.1 264 LQTSLNVTTEREKQLKQDLENLRDQHEKEKN 294
                 ****************999998888777665 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 1.6e-05
        Spc7 143 gleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesid.keeLeelreelaelkaeieekkkelaelqeqleeleekieelk 240
                 g e+++++l   +++L+ + +e+++ l++ +e+  +l++e+++l + +++ ++id +++ + +++ ++e ++++e+ + + aelq+ l e +++i +l+
  EFC38305.1 302 GKESQIQQLSISESELKVSIHEISQDLHSEREKSLKLTSEIDRLTNIVNQ-NQIDmNKSSNDVQQMVKESEEKYEKISSQFAELQSTLSERSNTILDLT 399
                 56777888888888888888888888888888888***********9988.889989999*************************************** PP

        Spc7 241 eqkseleeeiaeaervleeckgwsesevsrlkeevkaleeltgwkivslsg 291
                 ++ ++ +e +a+ ++++e + ++se+++++lk  +++ +++++ +i +l++
  EFC38305.1 400 NELHSENETVANLKKLIESNYMSSEKQIEELKLALNEHKNQLEERIKELED 450
                 *************************************99999999988874 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.0033
        Spc7 198 keeLeelreelaelkaeieekkkelaelqeqleeleekieelkeq 242
                  +eLe lr+ +++ ++ i  k ++++ l+++++++e+ +e++k  
  EFC38305.1 445 IKELEDLRSIITSKDEVITTKDDQISHLTQKKNNVESLLEKMKHD 489
                 234444444444444444444444444444444444444444433 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 9.5e-05
        Spc7 162 eeeldellpeleeekaeleeeleklqeaaeeles...idkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeaervl 257
                 e++l++++++ ++++++l  e +kl+e+++ l++      e ++++++el++ ++++ +++ +l+ +q++  +l++k+++l+e+ +++ + ++e ++ l
  EFC38305.1 480 ESLLEKMKHDASSNHETLVVENNKLEEEKNRLDNnyqQALETIKKIQDELRNSNETVISLQLQLEAKQKEHSSLNSKFNDLQEKFEDVSKTLQETKSDL 578
                 344455555566677778888888888777777732222333445556777777777777777777777777777777777777777777777777777 PP

        Spc7 258 eeckgwsesevsrlkeevkal 278
                  ++   +es +++l ++ +++
  EFC38305.1 579 TQQLTDKESLLKTLLQKTDDM 599
                 766666666666666666555 PP

  == domain 5  score: -0.8 bits;  conditional E-value: 0.095
        Spc7 143 gleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeeles...idkeeLeelreelaelkaeieekkkelaelqeqlee.leekie 237
                  ++++l++ +++ke         +e  ++l+e+ ++ ++el kl+e+ ++ ++   +++ eLe++ + + +l+++++++ +e ++l eql +  e+k +
  EFC38305.1 598 DMTKELAEYNKEKEAQITL----EEESKKLNEKLNTTNQELSKLKEELQNTTQdrdSTRSELENTLKIVYNLNNTVNSLTEEKDNLHEQLHTeMENKSQ 692
                 2333333444444433333....44444444444444445544444333333333378999*************************9999751555666 PP

        Spc7 238 elkeqkseleeeiaeaervleeckgwsesevsrlkeev 275
                   ++  s+l + + e+++ +++ k++ ese+++l+e  
  EFC38305.1 693 LENTLLSNLDKTTLEQRSEIQKLKEIYESEIKKLQEAS 730
                 6667789999999999999**************99865 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 0.15
        Spc7 173 eeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieek.kkelaelqeqleeleekieelkeqkseleeeiaeaervleeckgwsesevsr 270
                 e+++ +l+e  ++ +++ e+++++ ++e+  ++e+ ++  + ++ek ++e+++l++q  ++++ki++l+e  ++ ++ i+++      ++++ e+e+  
  EFC38305.1 739 EKYEFDLNELKTRYEREMESVKKSYQDEIGVMKESCETELNILKEKsEEEISQLNSQTSNQSSKIKQLSEDLRKSKDSIEKEI----SRRSSIEKELHD 833
                 23333333333333334445556778888888888877666665551467888888888888888888888888888888332....245677888888 PP

        Spc7 271 lkeevkaleel 281
                 l++++k+le++
  EFC38305.1 834 LQKQHKSLEKE 844
                 88888888876 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.0026
        Spc7 156 elLekqeeeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelk 240
                 ++L++ +++ ++l +e +e+k++le+ l++l+e+++el++i+++ +  l ++ ++ +++ +ek ke+ +l+++le+++ ++ e +
  EFC38305.1 829 KELHDLQKQHKSLEKESQEKKDTLEKSLKTLKEKEAELKEIKRDAID-LSKKCKSWEVTSQEKDKEIIKLKKELEKKTIALLEKT 912
                 67888899999999*****************************9996.7778999999999**************9998875554 PP

  == domain 8  score: 12.9 bits;  conditional E-value: 6.1e-06
        Spc7  160 kqeeel.dellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekiee..lkeqkseleeeiaea 253 
                  kqe  + +el+++l++ek++le+++++l ea +  ++  + e+  +++el+  kaei+ ++++l+elq+++++ +  i++  +k +k+++ + i+  
  EFC38305.1  914 KQEPAIdNELVKRLQKEKETLEQQVKELTEAPAA-SETPSIEVSMMKNELEMGKAEISDLREKLNELQQEKKKNQI-ISDigVKPSKDKILSHIQTL 1008
                  4555554899********************7775.7779*****************************99876554.44412466777788877766 PP

        Spc7  254 ervleeck 261 
                     +e+ k
  EFC38305.1 1009 IYAIEKAK 1016
                  65555554 PP

  == domain 9  score: -2.1 bits;  conditional E-value: 0.23
        Spc7  225 lqeqleeleekieelkeqkseleeeiaea 253 
                  +++q ++  +k+++ +e ++e+++ i++ 
  EFC38305.1 1043 VKQQ-KDTVSKFTKCEEIIKEMKSSIKQL 1070
                  2222.222233334444444444444444 PP

>> Filament  Intermediate filament protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0  19.8   9.3e-06     0.055     130     274 ..     164     310 ..     158     314 .. 0.92
   2 ?    2.9  54.9     0.011        68      20     285 ..     307     606 ..     306     608 .. 0.62
   3 ?   13.4  57.2   6.9e-06     0.041      21     283 ..     601     857 ..     598     862 .. 0.78
   4 ?   -4.9  26.8       2.7   1.6e+04      74     252 ..     863    1053 ..     857    1075 .] 0.74

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 9.3e-06
                 XXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXX-HHHHHHHHHHH CS
    Filament 130 keelaflkkvheeEvkelqkqvs..eqvlvevdaarkldLteilkeiraqyeelaeknreeaeewykskleelqea.aeknsealrsakeeitelrrqi 225
                 ++e++ lk+ +e+ + +l+++ +  ++ l+ v  ++  dL++   +ir++y e+++k  + + +  ++ + +++++ +e+ ++ + + k++++e  +q+
  EFC38305.1 164 TQEIEKLKQAYETIIFKLKSNNEsvKSKLLKVS-KEFKDLKKNQVDIRTEYLEQIQKTGSTLGSFTSTEIGKISSHlIEERNKIVTEFKSQLNEKMHQM 261
                 589*****************9987667777776.66789*********************************98762788888999************* PP

                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament 226 qsleieleslkkqkasleaqlaeleerleaeleklqeklseleeelaei 274
                 ++l++ l+   + +++l++ l++l +++e+e +++ ++ + +e++++++
  EFC38305.1 262 ETLQTSLNVTTEREKQLKQDLENLRDQHEKEKNDMVKSEEGKESQIQQL 310
                 **********************************************986 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.011
                 XXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..................XXXXXX CS
    Filament  20 VraLEqenkeLeakieeleekksaevsklkelyekeleelrkqldeltkerarlqleldnlreeledlrkkyeke..................lnkree 100
                 +++L  +++eL++ i+e ++  ++e++  +    +e++ l + +++ + + ++   +++++ +e e+  +k++++                  +n+ ++
  EFC38305.1 307 IQQLSISESELKVSIHEISQDLHSERE-KSLKLTSEIDRLTNIVNQNQIDMNKSSNDVQQMVKESEEKYEKISSQfaelqstlsersntildlTNELHS 404
                 577888899999999999999777777.566678999999999999999999999888888888887777777779999***********998666666 PP

                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXX............XXXXXXXXXXXXXXXXX CS
    Filament 101 vEaelkalrkdldeatlarvdLekkvesLkeelaflkkvheeEvkelqkqvs....eqvlvevdaarkld............Lteilkeiraqyeelae 183
                  ++++++l+k ++  +++    ek++e+Lk  l+  k+  ee +kel+   s    ++ ++ +++ +               L+++ ++  +++e+l+ 
  EFC38305.1 405 ENETVANLKKLIESNYMS---SEKQIEELKLALNEHKNQLEERIKELEDLRSiitsKDEVITTKDDQI-ShltqkknnveslLEKMKHDASSNHETLVV 499
                 666677777777777765...47777777777777777777765555443322223222222221111.122222333112244444444456777665 PP

                 XXXX.XXX.XXXXXXXXXXXXXXXXXXXXXXX-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH...HHH CS
    Filament 184 knre.eae.ewykskleelqeaaeknsealrsakeeitelrrqiqsleieleslkkqkasleaqlaeleerleaeleklqeklseleeelaei...ree 277
                 +n++ e e +   + ++++ e+++k +++lr+++e +  l+ q+++++ e +sl ++ + l+++ +++ ++l++  ++l ++l+++e+ l+++    ++
  EFC38305.1 500 ENNKlEEEkNRLDNNYQQALETIKKIQDELRNSNETVISLQLQLEAKQKEHSSLNSKFNDLQEKFEDVSKTLQETKSDLTQQLTDKESLLKTLlqkTDD 598
                 544312221345566666666667777777777777777777777777777777777777777777777777777777777777777655443111456 PP

                 HHHHHHHH CS
    Filament 278 marqlreY 285
                 m ++l eY
  EFC38305.1 599 MTKELAEY 606
                 66677777 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 6.9e-06
                 XXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXX CS
    Filament  21 raLEqenkeLeakieeleekksaevsklkelyekeleelrkqldeltkerarlqleldnlreeledlrkkyekelnkreevEaelkalr...kdldeat 116
                 + L + nke ea+i+  ee   ++ ++  ++ ++el++l+++l+++t++r+ ++ el+n+ + + +l++ +++ +++++++ ++l++      +l+++ 
  EFC38305.1 601 KELAEYNKEKEAQITLEEES--KKLNEKLNTTNQELSKLKEELQNTTQDRDSTRSELENTLKIVYNLNNTVNSLTEEKDNLHEQLHTEMenkSQLENTL 697
                 56778899999999998888..45555578889****************************************99999999999985432327788777 PP

                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.- CS
    Filament 117 larvdLekkvesLkeelaflkkvheeEvkelqkqvseqvlvevdaarkldLteilkeiraqyeelaeknreeaeewykskleelqeaaeknsealrs.a 214
                 l+   L+k   + + e++ lk+++e E+k+lq+   ++ +++ +++ + d    l+e+++ ye+     +e++++ y+  +  ++e+ e++ + l++ +
  EFC38305.1 698 LSN--LDKTTLEQRSEIQKLKEIYESEIKKLQEAS-KTEIINQKEKYEFD----LNELKTRYERE----MESVKKSYQDEIGVMKESCETELNILKEkS 785
                 764..55555666789*****************99.66666666666666....57899999865....556777899999999999999988887526 PP

                 HHHHHHHHHHHHHHHHHHHHH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament 215 keeitelrrqiqsleielesl....kkqkasleaqlaeleerleaeleklqeklseleeelaeireemarqlr 283
                 +eei++l+ q  + ++++++l    +k+k+s+e++++     +e+el++lq++ ++le+e +e ++++++ l+
  EFC38305.1 786 EEEISQLNSQTSNQSSKIKQLsedlRKSKDSIEKEISR-RSSIEKELHDLQKQHKSLEKESQEKKDTLEKSLK 857
                 78899999999999999877611114445555555543.3457889999999999999999999999988775 PP

  == domain 4  score: -4.9 bits;  conditional E-value: 2.7
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXX.X CS
    Filament   74 qleldnlreeledlrkkyekelnkreevEaelkalrkdldeatlarvdLekkve.....sLkeelaflkkvheeEvkelqkqvs..eqvlvevda.a 162 
                  ++el++++ ++ dl kk+++     +e ++e+ +l+k+l+++t+a ++  +k e     +L + l+  k+  e+ vkel++  +  e+ ++ev   +
  EFC38305.1  863 EAELKEIKRDAIDLSKKCKSWEVTSQEKDKEIIKLKKELEKKTIALLEKTAKQEpaidnELVKRLQKEKETLEQQVKELTEAPAasETPSIEVSMmK 959 
                  7899****************9999********************9999988876422234666678889999*******998776777778877625 PP

                  XXXXXXXX.XXXXXXXXXXXXXX.XXXXXXXXXXXX..XXXXXXXXXXXXXXXXX-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament  163 rkldLtei.lkeiraqyeelaek.nreeaeewyksk..leelqeaaeknsealrsakeeitelrrqiqsleieleslkkqkasleaqlaeleer 252 
                  ++l++ ++ ++++r++ +el ++ +++++ +    k   +++ +++++   a+++ak+e   ++++ + le ele  k +  s+++q   + + 
  EFC38305.1  960 NELEMGKAeISDLREKLNELQQEkKKNQIISDIGVKpsKDKILSHIQTLIYAIEKAKQEKYHYKKTCKLLEQELELWKCAVPSVKQQKDTVSKF 1053
                  5688987769******988766504555555555551156677888888899999999999999999999999998888777777665444332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1075 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5227  (0.291539); expected 358.6 (0.02)
Passed bias filter:                      840  (0.0468515); expected 358.6 (0.02)
Passed Vit filter:                       440  (0.0245412); expected 17.9 (0.001)
Passed Fwd filter:                       169  (0.00942607); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 6.35u 0.47s 00:00:06.81 Elapsed: 00:00:01.24
# Mc/sec: 2614.33
//
Query:       EFC38306.1  [L=435]
Description: beta-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.3e-38  132.4   0.1    3.1e-37  128.7   0.1    2.5  1  Tubulin    Tubulin/FtsZ family, GTPase domain
    1.8e-18   66.9   1.3    2.7e-18   66.3   1.3    1.3  1  Tubulin_C  Tubulin C-terminal domain
    0.00031   20.5   0.0     0.0014   18.3   0.0    2.1  2  Tubulin_3  Tubulin domain
     0.0067   16.4   0.7       0.14   12.1   0.0    2.3  2  Sec2p      GDP/GTP exchange factor Sec2p


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.7   0.1   6.8e-41   3.1e-37       2     196 ..       4     200 ..       3     201 .. 0.86

  Alignments for each domain:
  == domain 1  score: 128.7 bits;  conditional E-value: 6.8e-41
                 EEEEEEHHHHHHHHHHHHH...HHHCH.....HHHT.....TTEEEEE......EEESBHHHHHTS-GS......EEEE--CCCCTTC--TT-HHHHHH CS
     Tubulin   2 iivigvGqcGnqignelwellakehgiq.sdgdslesfFsesgkveyi..prsvaidtdpqvlneikagselfnpnklllgkegagnngaggypevgke 97 
                 i+ i +G+cGn+ig+++w+ l++eh+++  +g++++s  s ++  + i    + ++  ++++ + + +  +l++++   +g+ g gn++ +gy++ g+ 
  EFC38306.1   4 IVSICIGGCGNRIGSSFWKHLMREHHLNiFTGEKIDSATSSDQ-LKAIaeEHCNIFLHEKEDGKFVPRV-KLLESKFATFGNCGNGNSFGNGYYTDGSL 100
                 899************************8777766666655544.3333122233333455555555555.88999999********************* PP

                 HHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--..GG.G-HHHHHHHHHHHHHHHHT-SEEEEEEHHHHHC CS
     Tubulin  98 aaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs..efsevvvepynailalkelieesdavividNdaLlk 194
                 ++ +i++++r+++e+cd+l+gf++++s+ GG+GSGlg++il  l+++yp +++ t +vlPs   f    ++ yn++l++++l   s +v+++dN+aL +
  EFC38306.1 101 LEPKIMDQVRRRIEQCDYLDGFQVFHSIIGGSGSGLGSKILTHLSDDYPSKFIGTTSVLPSeeCFGGRSLSYYNSVLSVQSLL-ASTFVTLFDNQALEQ 198
                 *************************************************************977788899************9.899**********99 PP

                 CS CS
     Tubulin 195 il 196
                  +
  EFC38306.1 199 YC 200
                 87 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.3   1.3   6.1e-22   2.7e-18       1     125 [.     250     373 ..     250     374 .. 0.92

  Alignments for each domain:
  == domain 1  score: 66.3 bits;  conditional E-value: 6.1e-22
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEESSS.HHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEE.CE CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirGdve.pkevnkavqrikekkkaqfveWiptgikvalnk.ks 97 
                 PrlhF+ +s + +  + k+   k +++++tr+l++++n +   + ++gkyl+  +++rG ++ ++ +++   +ik ++++qf +Wi ++i+++l++  s
  EFC38306.1 250 PRLHFFSISRSQMEVNVKN-GIKSTLETLTRNLFDSSNNLLTLNSQQGKYLTSNICYRGTISnISMIEECAGKIKIQNESQFSKWIHSSIHTSLCEtIS 347
                 9**********98887665.557789***********************************73578999999***********************8359 PP

                 CT-TTTSSCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C  98 pyvkkqskvsvlmlaNttsiaelfkrll 125
                 p+ k +s  s+ m++N t i ++fkr++
  EFC38306.1 348 PVCKFNS--SASMISNATFITQAFKRIR 373
                 9999999..*****************96 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   3.2e-07    0.0014      59     142 ..     105     182 ..      76     212 .. 0.75
   2 ?   -1.6   0.0       0.4   1.8e+03     154     176 ..     325     347 ..     281     351 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 3.2e-07
   Tubulin_3  59 lldrdlrpfaeecdqlrglqvftgvddaWG.GfaakylerlrdeygkksilvWvlaleeklkkkkkaklerklkklnkarslkel 142
                 ++d  +r  +e+cd l g+qvf ++    G G ++k l +l d+y++k i      +++ l +++     r+l+  n+  s+++l
  EFC38306.1 105 IMD-QVRRRIEQCDYLDGFQVFHSIIGGSGsGLGSKILTHLSDDYPSKFIG-----TTSVLPSEEC-FGGRSLSYYNSVLSVQSL 182
                 555.48899*************9987655549**************99863.....2222222222.223455555666655555 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.4
   Tubulin_3 154 klsdaeseWhtsaLlssalesvt 176
                 + +++ s+W +s++ +s  e+++
  EFC38306.1 325 QNESQFSKWIHSSIHTSLCETIS 347
                 23356788999999999999885 PP

>> Sec2p  GDP/GTP exchange factor Sec2p
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   3.2e-05      0.14      16      42 ..     267     293 ..     257     302 .. 0.79
   2 ?    2.1   0.1     0.043   1.9e+02      31      66 ..     352     387 ..     351     400 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.2e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       Sec2p  16 kkklekEledLtasLFeeANkmVaaar 42 
                 k+ +++ le+Lt++LF+  N++ +  +
  EFC38306.1 267 KNGIKSTLETLTRNLFDSSNNLLTLNS 293
                 6789****************9976555 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.043
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHCHCC CS
       Sec2p  31 FeeANkmVaaarkekealekkneklkeqLkeketll 66 
                 F+   +m+++a   ++a+++  +  k+qLk k  l 
  EFC38306.1 352 FNSSASMISNATFITQAFKRIRDTFKNQLKRKAYLS 387
                 566678************************987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (435 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       598  (0.0333538); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 2941.26
//
Query:       EFC38307.1  [L=667]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-71  240.7   0.0    2.5e-71  240.1   0.0    1.2  1  Pkinase        Protein kinase domain
    2.8e-31  108.7   0.0    8.1e-31  107.2   0.0    1.7  1  Pkinase_Tyr    Protein tyrosine kinase
    8.6e-05   22.0   0.0    0.00022   20.6   0.0    1.6  2  Kinase-like    Kinase-like
    0.00063   18.8  17.5    0.00063   18.8  17.5    2.9  2  Haspin_kinase  Haspin like kinase domain
     0.0022   17.4   1.3     0.0028   17.0   0.3    1.7  2  Kdo            Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
          1    7.8  45.3     0.0046   15.6  16.3    2.1  2  Macoilin       Macoilin family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  240.1   0.0   8.3e-75   2.5e-71       3     264 .]     213     505 ..     211     505 .. 0.91

  Alignments for each domain:
  == domain 1  score: 240.1 bits;  conditional E-value: 8.3e-75
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH..HHHHHHHHHHHHHSCTTB--EEEE.EEESSEEEEEEE--TTEBHHHHHHHHSS--HH CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkke..kkvlrEikilkklkhpnivrlyev.feekdelylvleyveggeladllerkgslsee 98 
                 ++ k+GeG++G+V+kav+k+++  vA+Kki+ + +++k+    + +rEi+ilk+++h+niv+l++v +++k +++lv+eyv+++ la l  +   ++e+
  EFC38307.1 213 DEGKVGEGTYGEVFKAVDKRDNSLVAIKKIRIDPQREKEGfpITSIREIRILKEIEHKNIVKLLDVtWNSKGTFFLVFEYVDHD-LAGLNAKGHRFDED 310
                 5689***************************999998888889**********************8356688999*******77.9999988888**** PP

                 HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHHHHHSS- CS
     Pkinase  99 eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvl.keneyskkvDvWslGvilyelltgkp 195
                 e+++i++q+l++l+ +Hs+ i+HrDlK +N+Li+++g lK++DFGl++ ++++++ +t++v+t++Y++PE+l +++ y+ +vD+Ws+G+il e+l    
  EFC38307.1 311 ELRSIMYQLLNALHCCHSRDIMHRDLKASNVLIKKDGTLKLADFGLSRIAQKNKQeYTNRVVTRWYRPPELLlGATTYDYAVDMWSVGCILGEML---L 406
                 *************************************************9998888****************999*******************6...6 PP

                 STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHHTTS..........................-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 196 pfsgekgkekvekeldqlekilkilg....etkeklpeasei..........................seeakdllkkllkkdpkkRltaeellqhpyl 264
                 pf+gek+ +      d++ ++ ki++    +++e+++e +++                          s++++dll+kll  +p kRlt +e+l+h+++
  EFC38307.1 407 PFAGEKEPKALFPGSDDVNQLEKIFEwcgtPSTEEWAEVENLahwnalkpkeskkrrllerfanlkscSKKVLDLLDKLLVLNPAKRLTTNECLNHDWF 505
                 8888888887766666655555555554477777888888889*******************************************************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.2   0.0   2.7e-34   8.1e-31       6     200 ..     216     406 ..     212     502 .. 0.80

  Alignments for each domain:
  == domain 1  score: 107.2 bits;  conditional E-value: 2.7e-34
                  EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH...HHHHHHHHHHHHTS-BTTB--EEEEEE.SSSSEEEEEE--TTEBHHHHHHHTCTTT CS
  Pkinase_Tyr   6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateee...keelleeakimkklkhpnivkllgvct.keepllivteyvkgGdLlkfLrkkekek 99 
                  k+GeG++G+V+++  k    +++  Va+K+++ + ++e+       ++e++i+k+++h+nivkll v   ++++ ++v+eyv++  L   L++k  ++
   EFC38307.1 216 KVGEGTYGEVFKAVDK----RDNSLVAIKKIRIDPQREKegfPITSIREIRILKEIEHKNIVKLLDVTWnSKGTFFLVFEYVDHD-L-AGLNAK-GHR 306
                  79***********999....88899******76655553233456689********************9677789********95.5.568998.9** PP

                  SBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS.-HHHHHHSE.EEHHHHHHHHHHHH CS
  Pkinase_Tyr 100 ltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWm.apEslkekk.ftsksDvWsfGvll 195
                  ++ ++l s+++q+ ++++  +s++++Hrdl a NvL++++ + k++DfGL+r     ++ +++ ++++  +W+ +pE l   + +  + D+Ws G +l
   EFC38307.1 307 FDEDELRSIMYQLLNALHCCHSRDIMHRDLKASNVLIKKDGTLKLADFGLSRIA---QKNKQEYTNRVVTRWYrPPELLLGATtYDYAVDMWSVGCIL 401
                  ****************************************************98...4444455667788887699998765449************* PP

                  HHHHT CS
  Pkinase_Tyr 196 wEift 200
                   E++ 
   EFC38307.1 402 GEMLL 406
                  **974 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   7.4e-08   0.00022     146     238 ..     313     399 ..     295     414 .. 0.77
   2 ?   -2.5   0.1      0.81   2.4e+03     249     285 ..     437     490 ..     430     493 .. 0.57

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 7.4e-08
  Kinase-like 146 rlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLv...ragtkvvlsevekgfaPpEllgsrggytrknktkmthkldaWqlGl 238
                  r ++  ql++     +++ ++h ++++ n+l +++g l+l +f+  +   + ++++    v + + PpEll  +        t++ +++d W +G 
   EFC38307.1 313 RSIM-YQLLNALHCCHSRDIMHRDLKASNVLIKKDGTLKLADFGLSRiaqKNKQEYTNRVVTRWYRPPELLLGA--------TTYDYAVDMWSVGC 399
                  5555.78888888899**************************9743211133444443445599******9873........56778889999886 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.81
  Kinase-like 249 Pltlateeakeew.................kfklckkipekvkaLlkkfLqlsq 285
                  P t+ + e+++                    f   k  ++kv  Ll k+L l+ 
   EFC38307.1 437 PSTEEWAEVENLAhwnalkpkeskkrrlleRFANLKSCSKKVLDLLDKLLVLNP 490
                  666666555543212555555555555555667777777777777777776665 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8  17.5   2.1e-07   0.00063       9     266 ..      93     368 ..      80     393 .. 0.57
   2 ?  -15.6  15.0         6   1.8e+04      15      40 ..     591     616 ..     576     635 .. 0.44

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 2.1e-07
  Haspin_kinase   9 slksrssqsslkhktshssLqkfsssssessssnkislPvkdq..........................vsrdkikkklrnsesllslnsqeevkd 78 
                    s  s ss+ss  h  s+ s  +    +s+ssssn+ s+ +++                           v                 ln ++++ +
     EFC38307.1  93 SNASSSSNSSYHHHRSNNSTTHH---NSTSSSSNNTSSSTQNGerrpppptttttttkdssshpppppvV-----------------LNGTQKPHP 168
                    44444555555444443333332...22233333333333333222222222222222222222222211.................222222222 PP

  Haspin_kinase  79 fdevils...qilelckikkilneadlasllnd.........................seklssevyqtke..kdkevvlKviplevledvtiske 144
                     d++  +   +  +  +i    ++++     n+                         +e+ ++ev+++ +  +++ v++K+i ++ + + +   +
     EFC38307.1 169 TDNTTTRvqnNNNNTTTI----KPNN-----NNftrpnpprnplaerfqhiekdegkvGEGTYGEVFKAVDkrDNSLVAIKKIRIDPQREKEGFPI 255
                    222221110022222222....1211.....112222234445555666666677788***********9977788899******99999888888 PP

  Haspin_kinase 145 lslkelkslklvkgtypglllllqdkvlkekpdfyseqqlflvlllkdkGtdLeevklk....swkqalsifwqivkiLyvaEtkfeFEHRdLhld 236
                    +s+ e + lk ++ +          +++k   d++ + + +  l++++  +dL+ ++ k    + ++  si++q ++ L+   ++ +  HRdL+  
     EFC38307.1 256 TSIREIRILKEIEHK----------NIVKLL-DVTWNSKGTFFLVFEYVDHDLAGLNAKghrfDEDELRSIMYQLLNALHCCHSR-DIMHRDLKAS 339
                    888887777666555..........333333.4555666789999*********99776222245799*************9887.899******* PP

  Haspin_kinase 237 niLvdknlnvtlidlklsRlessegkvlyt 266
                    n+L++k ++  l d+ lsR+ +++++  yt
     EFC38307.1 340 NVLIKKDGTLKLADFGLSRIAQKNKQE-YT 368
                    ********************9444433.32 PP

  == domain 2  score: -15.6 bits;  conditional E-value: 6
  Haspin_kinase  15 sqsslkhktshssLqkf.....sssssesss 40 
                    s++  +h ++ ss ++      +     s++
     EFC38307.1 591 SSHHSSHHSNTSSSHHNgsshhN-----SHH 616
                    22222333333333333222221.....111 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.3   9.5e-07    0.0028      58     169 ..     257     357 ..     247     375 .. 0.76
   2 ?   -3.4   0.0       1.7   5.1e+03      96     128 ..     439     469 ..     439     471 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 9.5e-07
         Kdo  58 avrEfrllkrLeeagvavpkpvaagavkvgleyrAlllterlegaqdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqeee 156
                 + rE+r+lk+ e++ +  +  v  + +  g   + +l+ e +++  dL+ l ak+++++e   r ++ ++  + +  h+++++H+dl a n+l+++++ 
  EFC38307.1 257 SIREIRILKEIEHKNIVKLLDVTWNSK--G---TFFLVFEYVDH--DLAGLNAKGHRFDEDELRSIMYQLLNALHCCHSRDIMHRDLKASNVLIKKDG- 347
                 556666666666655443333333322..2...34788888885..9**********999999999999****************************9. PP

         Kdo 157 eeaeiwliDldka 169
                    ++ l D+  +
  EFC38307.1 348 ---TLKLADFGLS 357
                 ...7888887554 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.7
         Kdo  96 terlegaqdLedllakwaelaeelkrallkavg 128
                 te+ +++++L+ + a   +++e++kr+ll++ +
  EFC38307.1 439 TEEWAEVENLAHWNAL--KPKESKKRRLLERFA 469
                 5777777788887775..688999999888766 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.6  16.3   1.6e-06    0.0046     254     383 ..      19     150 ..       1     327 [. 0.63
   2 ?   -1.4  21.0      0.22   6.5e+02     247     383 ..     513     646 ..     457     666 .. 0.45

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.6e-06
    Macoilin 254 eyrekkksakssrsdskkkhehn.....esvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskkasagsagssnsssk 347
                 + +++k+s++s+r+ ++     n     ++vd++ ++++   ++ ++ ++s + s++ +    +++  +sk++ssss+sn +s+++s+     sn+s+ 
  EFC38307.1  19 DDHNNKESNHSRRNYHGDY---NdrrsrDDVDNRERRHSGGRSNYNNYNSSANGSTS-SGGNSTNNYHSSKHHSSSSNSNASSSSNSSYHHHRSNNSTT 113
                 2222223333332222222...12233344555555555444444444443332322.23334444455666667777777777777777888888888 PP

    Macoilin 348 khsessksv.tsssssknskkqklpaGkssaalkdaa 383
                 +h+++s+s  ++sss++n +++  p   +++++kd+ 
  EFC38307.1 114 HHNSTSSSSnNTSSSTQNGERRPPPPTTTTTTTKDSS 150
                 8887766541445555555555333333344444443 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.22
    Macoilin 247 slklpeleyrekkksakssrsdskkkh.ehnesvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskkasagsagssns 344
                 ++kl +l +  +++  + ++ d+k +  +h+    + +q+  +  n+s    +++s+++   s+   ++s + +++ +ss+ +++++++s++  + s+ 
  EFC38307.1 513 NIKLKNLPSTATNEFLTRKKGDNKPNApSHQLPGSTSVQQLPHNINQSYGVSSTSSSHPPFGSSNGNRHSYNPSHHHQSSHHSSHHSNTSSSHHNGSSH 611
                 344444444444333333333333322022222334444444444444433333332222222222222222222223333223333333322222222 PP

    Macoilin 345 sskkhsessksvtsssssknskkqklpaGkssaalkdaa 383
                    +h+++s++  ss    +s+  ++++G+s++ ++d+ 
  EFC38307.1 612 HNSHHHHQSSHHHSS----SSHHGSTGSGHSNNYHRDNR 646
                 222222222222222....22233445555555444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (667 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1904  (0.106197); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                       143  (0.0079759); expected 17.9 (0.001)
Passed Fwd filter:                        66  (0.00368119); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.34u 0.39s 00:00:01.73 Elapsed: 00:00:00.57
# Mc/sec: 3493.73
//
Query:       EFC38308.1  [L=813]
Description: hypothetical protein NAEGRDRAFT_59563 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.8e-42  143.3   0.0      2e-40  138.8   0.0    2.2  1  FAD_binding_1  FAD binding domain
    6.7e-25   88.0   0.0    2.2e-20   73.3   0.0    2.4  2  Flavodoxin_1   Flavodoxin
    6.6e-14   52.5   0.0    1.6e-13   51.2   0.0    1.7  1  NAD_binding_1  Oxidoreductase NAD-binding domain
  ------ inclusion threshold ------
      0.042   14.1   0.0        0.1   12.8   0.0    1.6  1  Flavodoxin_5   Flavodoxin domain
      0.058   13.1   0.0        0.2   11.4   0.0    1.9  1  Flavodoxin_3   Flavodoxin domain


Domain annotation for each model (and alignments):
>> FAD_binding_1  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  138.8   0.0   5.4e-44     2e-40       8     222 .]     374     618 ..     370     618 .. 0.90

  Alignments for each domain:
  == domain 1  score: 138.8 bits;  conditional E-value: 5.4e-44
                    -EEEEEEEEEE---.-SS--EEEEEEE-TTB......T----TT-EEEE-----HHHHHHHHHHHT--T..T-EEEEEESSTT............. CS
  FAD_binding_1   8 vflakvlknreLtkpesernvihveldisds......glkYetGdhlgvypsNneelVeellellgldpkadevvelkaldee............. 84 
                    vf a+v   r Lt +es+++v+h+e+di+          kYe+Gd+lgv+ +N++++V++lle l+      +  e+++ ++              
     EFC38308.1 374 VFSAAVHGARYLTTTESSKQVLHLEFDINSApisddaTFKYEPGDSLGVFCENDQDQVDALLEKLKEIG-SLKHYEVPNGKKGiqseplrendlis 468
                    899************************987666666899***********************9998655.34555665555335566777778888 PP

                    ...............S--SSSSSEEHHHHHHHTB--SS---HHHHHHHGGG-SSHHHHHHHHHHHH-HHHHHTTTTT--HHHHHHHHHTT---TTS CS
  FAD_binding_1  85 .............saekeprleptTlrqalkyylditgppskqlleaLaefaseeeekqkLekLssdegakeykelklneartllevleefpsvkl 167
                                 +   +   e + lr+++++ +di++p++  +l+ La++ ++  ek  L kL  d   + y++  ++++  l ++l  +ps k+
     EFC38308.1 469 ikcideskkclfpNHFLAGEDEAIRLRTIFTKRVDIMSPVTIPMLQMLAKYCTNFLEKSALLKLTFD--TNMYNTQIVKQRANLYDILCWYPSCKP 562
                    88888889988887777888899*******************************************9..9999999999***************** PP

                    -HHHHHHHS-B---EEEEB-S-TTTTTTEEEEEEE--EE--.-SSS--EE-HHHHH CS
  FAD_binding_1 168 plefLlevlpqLkpRyYSiSssskvhpdevhltvvVveyet.dgegrirkGvcsny 222
                    pl++Ll+ ++ L+pR+YSiSss+ +hpdevh++  Vv++et  ++  +r G c+++
     EFC38308.1 563 PLNHLLQEMSPLQPRFYSISSSPIKHPDEVHIAFSVVKFETpPPHRTTRVGCCTHW 618
                    *****************************************9999999*******9 PP

>> Flavodoxin_1  Flavodoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.0   4.2e-05      0.15       1      30 [.       8      36 ..       8      53 .. 0.79
   2 !   73.3   0.0   6.2e-24   2.2e-20      16     139 ..      57     173 ..      50     177 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.2e-05
                  EEEETSSSHHHHHHHHHHHHHHHTTTEEEE CS
  Flavodoxin_1  1 ilYgSetGnteklAkqlaeelgehgfnadv 30
                  i YgSetGn++++A ++ +e  +++f  + 
    EFC38308.1  8 ICYGSETGNSKAIATRIFKECVDQQFA-KD 36
                  78*****************99988884.33 PP

  == domain 2  score: 73.3 bits;  conditional E-value: 6.2e-24
                   HHHHHHHHTTTEEEEEEEEGTTSC..GGGGGTHSEEEEEEEEETTTBEEGGGHHHHHHHHHHHCHHGCCSTTTTEEEEEEEEECTTSSSTTHHHHHH CS
  Flavodoxin_1  16 qlaeelgehgfnadvvslsdydes..lseieeealllvvtsTfgnGdppengesffqdllelkgdeledgdlsgvrfavfglGdsayenFcaagkkl 110
                   +l++  +++ ++a    +++   +     ++++a+ ++++sT+gnGd+p+ng  +f+++++lk+++ ++  +s++++ ++glGds+y  Fc+a++ +
    EFC38308.1  57 TLKQSPSSNNLQA----MDNTTTTtnGHILDSKANMIIICSTTGNGDVPQNGD-NFYRFIKLKSTPANF--FSNLSYTILGLGDSNYDMFCNAARNI 146
                   5555555433333....33333334356788999*******************.*********877666..************************** PP

                   HHHHHHTTCEEESSSEEEETTSTHGHHHH CS
  Flavodoxin_1 111 dekleelGaerllkllegdednqegqeea 139
                   d++l+elGa+r+   +e+de    g+e a
    EFC38308.1 147 DKRLTELGADRFSNRGEADEVV--GLEVA 173
                   *******************977..66655 PP

>> NAD_binding_1  Oxidoreductase NAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.2   0.0   4.4e-17   1.6e-13       1     107 [.     657     775 ..     657     777 .. 0.82

  Alignments for each domain:
  == domain 1  score: 51.2 bits;  conditional E-value: 4.4e-17
                    EEEEGGGGHHHHHHHHHHHHHCT...TCSEEEEEEEESSGC.GSTTHHHHHHHHHHCTTEEEEEEEESSCTTT....SSSEESSHHHHHHHHHHH. CS
  NAD_binding_1   1 miagGtGiaPvrsvlraileeak...dktkvvlvyGnrtee.dllyreeleelakklpgrlkvvavvsreeag....weggkgrvqdalleells. 87 
                    mi++GtG+ P+rs+l+++  + +    ++  +l++G+r+ + d+lyr++l+ ++++   +l+++ + sre+++    w +g ++vqd l e++ + 
     EFC38308.1 657 MIGPGTGVVPFRSFLQHRECQLDkkqSDGTNWLFFGCRSIRsDFLYRDDLRDFETESFVNLNLLVACSREANSgggvW-YGGSYVQDYLKEYSSNi 751
                    9****************9887333567899*********988***********9988887777666455444312225.8999******8877778 PP

                    ...HSSTTEEEEEEC.SHHHHHHH CS
  NAD_binding_1  88 ...lkkeethvyvCG.ppgMikav 107
                       +  ++  +yvCG ++gM++ v
     EFC38308.1 752 aeiMIMKKGCLYVCGdAQGMATQV 775
                    889779999*******9***9987 PP

>> Flavodoxin_5  Flavodoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   2.8e-05       0.1       1      34 [.       7      42 ..       7      55 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.8e-05
  Flavodoxin_5  1 lilYsSrdGqTkkiaeriaeelree..gelvdvedv 34
                  li+Y S +G++k ia+ri +e+ ++  ++++++ ++
    EFC38308.1  7 LICYGSETGNSKAIATRIFKECVDQqfAKDTQLLSL 42
                  8********************998867666665555 PP

>> Flavodoxin_3  Flavodoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   5.5e-05       0.2       1      24 [.       7      30 ..       7      50 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 5.5e-05
  Flavodoxin_3  1 lilysSltGNTkkvAeaikealee 24
                  li y S+tGN k++A  i++++ +
    EFC38308.1  7 LICYGSETGNSKAIATRIFKECVD 30
                  599****************99877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (813 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       748  (0.0417201); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.81u 0.40s 00:00:01.21 Elapsed: 00:00:00.55
# Mc/sec: 4442.16
//
Query:       EFC38309.1  [L=557]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.4e-77  256.9   1.4    1.6e-76  256.2   1.4    1.3  1  DUF667    Protein of unknown function (DUF667)
    1.6e-21   76.4   0.1      2e-12   47.4   0.0    2.5  3  Ank_4     Ankyrin repeats (many copies)
    3.3e-15   56.4   0.7    2.5e-14   53.6   0.4    2.2  2  Ank_2     Ankyrin repeats (3 copies)
    8.5e-13   48.3   0.0    1.8e-08   34.5   0.0    2.8  2  Ank_5     Ankyrin repeats (many copies)
    5.3e-11   41.8   0.1    0.00013   22.1   0.0    3.7  3  Ank_3     Ankyrin repeat
    2.4e-09   37.2   0.1     0.0031   17.9   0.0    3.2  3  Ank       Ankyrin repeat
     0.0029   17.4   0.6     0.0062   16.3   0.6    1.5  1  UPF0640   Uncharacterised protein family UPF0640


Domain annotation for each model (and alignments):
>> DUF667  Protein of unknown function (DUF667)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  256.2   1.4   6.1e-80   1.6e-76      28     184 ..     394     550 ..     381     551 .. 0.97

  Alignments for each domain:
  == domain 1  score: 256.2 bits;  conditional E-value: 6.1e-80
      DUF667  28 kvknGhikrvlDeeikskvleiegknvattyitcPadpkesLgiklpfLvllvknlkkyFsfeiqilddkkirrrlrfsnfqkktkvkslivtlPlrln 126
                 +vknGhikr++D++i+s+vle+ g+nv+ttyitcPa +k++LgiklpfLv+++knlkkyF+fe+q+lddk+i+rr+r+sn+q++t+vk++i+t+P+rl+
  EFC38309.1 394 EVKNGHIKRITDQDIQSSVLELIGTNVSTTYITCPASAKKTLGIKLPFLVMVIKNLKKYFTFEVQVLDDKNIKRRFRASNYQSTTRVKPFICTMPMRLD 492
                 79************************************************************************************************* PP

      DUF667 127 egWnqlqlnLaeltrkaygtnyketkrvqihancrlrrvYfsdrlYsedelpkefklf 184
                 egWnq+q+nLa++tr+aygtny et rvqihancr+rr+YfsdrlYse +lp+ef+lf
  EFC38309.1 493 EGWNQIQFNLADFTRRAYGTNYIETLRVQIHANCRIRRIYFSDRLYSESDLPDEFRLF 550
                 ********************************************************98 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.0   3.3e-05     0.086      10      55 .]     132     179 ..     129     179 .. 0.85
   2 !   47.4   0.0   7.7e-16     2e-12       3      55 .]     161     212 ..     159     212 .. 0.96
   3 !   28.1   0.0   8.4e-10   2.2e-06       3      54 ..     194     244 ..     192     244 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.3e-05
       Ank_4  10 isgrlelvrlLle.kgadinaqdnrsGe..talhiAakrgnveilklLl 55 
                 i g+le  + L+e k  +++   +r G   +al++A+ +g++ei+k+L+
  EFC38309.1 132 INGNLEKMKELVEvKFFNVDTI-DRFGYncSALQFAVNGGKLEIVKYLI 179
                 5688888899998667888897.99988446*****************8 PP

  == domain 2  score: 47.4 bits;  conditional E-value: 7.7e-16
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklLl 55 
                 +aL  a++ g+le+v++L++k+a++n   + sGetalh+A+k+gn+e++klLl
  EFC38309.1 161 SALQFAVNGGKLEIVKYLISKNANVNLI-DVSGETALHKACKKGNLEMVKLLL 212
                 57889999*******************8.***********************8 PP

  == domain 3  score: 28.1 bits;  conditional E-value: 8.4e-10
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklL 54 
                 taLh+a+++g+le+v+lLl  g++ +++ n+ G +++ i   +g+ ei ++L
  EFC38309.1 194 TALHKACKKGNLEMVKLLLKAGIQKDYV-NKLGKSPINILTEKGFTEISHYL 244
                 89**********************9999.999*****999999999998887 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.6   0.4   9.7e-18   2.5e-14       4      80 ..     130     219 ..     127     222 .. 0.82
   2 ?    0.3   0.0      0.42   1.1e+03      25      49 ..     224     254 ..     216     282 .. 0.67

  Alignments for each domain:
  == domain 1  score: 53.6 bits;  conditional E-value: 9.7e-18
       Ank_2   4 AakngnlelvklLl..egadpn..k...ngktaLhyAakngnleivklLleh......adndgrtpLhyAarsghleivklLlekgadin 80 
                  a ngnle +k L+  + ++++  +    + +aL++A+ +g+leivk+L+++      +d +g+t+Lh A+++g+le+vklLl+ g++++
  EFC38309.1 130 SAINGNLEKMKELVevKFFNVDtiDrfgYNCSALQFAVNGGKLEIVKYLISKnanvnlIDVSGETALHKACKKGNLEMVKLLLKAGIQKD 219
                 5789999*******75445555543677889*******************976665555599*********************8788765 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.42
       Ank_2  25 ngktaLhyAakngnleivklLleh......a 49 
                  gk+++ + +++g +ei  +L ++      a
  EFC38309.1 224 LGKSPINILTEKGFTEISHYLSNFdylfylA 254
                 6899999999999999999998844455552 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.0   2.4e-07   0.00063       8      52 ..     149     195 ..     146     195 .. 0.95
   2 !   34.5   0.0   6.9e-12   1.8e-08       3      54 ..     180     230 ..     178     232 .. 0.90

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 2.4e-07
       Ank_5   8 dvnrldgggn..tpLhvAakygaadvvrlLlargadlnltdsrGlta 52 
                 +v++ d++g+  ++L +A+++g +++v++L+  +a+ nl d +G+ta
  EFC38309.1 149 NVDTIDRFGYncSALQFAVNGGKLEIVKYLISKNANVNLIDVSGETA 195
                 788999999999*********************************98 PP

  == domain 2  score: 34.5 bits;  conditional E-value: 6.9e-12
       Ank_5   3 ehgpadvnrldgggntpLhvAakygaadvvrlLlargadlnltdsrGltald 54 
                 ++  a+vn  d  g+t+Lh A+k+g++++v+lLl+ g   +  ++ G++++ 
  EFC38309.1 180 SKN-ANVNLIDVSGETALHKACKKGNLEMVKLLLKAGIQKDYVNKLGKSPIN 230
                 555.9********************************999999999999976 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       1.3   3.4e+03      10      30 ..     131     151 ..     130     152 .. 0.83
   2 !   15.0   0.0   1.1e-05     0.027       1      30 [.     158     186 ..     158     187 .. 0.94
   3 !   22.1   0.0     5e-08   0.00013       2      27 ..     192     216 ..     191     219 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.3
       Ank_3  10 arsgnleivkfLlenkgadvn 30 
                 a +gnle +k L+e k  +v+
  EFC38309.1 131 AINGNLEKMKELVEVKFFNVD 151
                 67999999*****98887776 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.1e-05
       Ank_3   1 nGetpLhlAarsgnleivkfLlenkgadvn 30 
                 +++++L +A+  g+leivk+L+  k+a+vn
  EFC38309.1 158 YNCSALQFAVNGGKLEIVKYLIS-KNANVN 186
                 5789*******************.9***99 PP

  == domain 3  score: 22.1 bits;  conditional E-value: 5e-08
       Ank_3   2 GetpLhlAarsgnleivkfLlenkga 27 
                 Get+Lh A++ gnle+vk+Ll+  g+
  EFC38309.1 192 GETALHKACKKGNLEMVKLLLK-AGI 216
                 9********************9.665 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   7.5e-06     0.019       3      31 ..     160     189 ..     158     190 .. 0.89
   2 !   17.9   0.0   1.2e-06    0.0031       2      24 ..     192     215 ..     191     225 .. 0.87
   3 ?   -1.2   0.0       1.3   3.3e+03       5      17 ..     317     335 ..     315     338 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 7.5e-06
                 BBHHHHHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   3 nTPLHlAatngkkriiklLL.hGAnlnald 31 
                 +++L  A+++gk++i+k+L+ + An+n+ d
  EFC38309.1 160 CSALQFAVNGGKLEIVKYLIsKNANVNLID 189
                 789999**99**********768****987 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 1.2e-06
                 SBBHHHHHHHHTTHHHHHHHH.TT CS
         Ank   2 GnTPLHlAatngkkriiklLL.hG 24 
                 G T+LH A+  g+++++klLL  G
  EFC38309.1 192 GETALHKACKKGNLEMVKLLLkAG 215
                 99*******************556 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.3
                 HHHHHH......HHTTHHH CS
         Ank   5 PLHlAa......tngkkri 17 
                 PLHl +      ++gkk+i
  EFC38309.1 317 PLHLVSfvlqkaQIGKKSI 335
                 9**9656666666666665 PP

>> UPF0640  Uncharacterised protein family UPF0640
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.6   2.4e-06    0.0062      24      64 ..     342     377 ..     320     380 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.4e-06
     UPF0640  24 flPlFFvlGaalEfsminvrvgkenFYdvykrkqaerlvee 64 
                  +P+FF +G  +E +m++     + FY+  krk++e l  +
  EFC38309.1 342 IVPFFFGVGFSMEVFMVK-----TGFYEYRKRKESETLTAK 377
                 79**************96.....78***9999999988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (557 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       752  (0.0419432); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.73u 0.36s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 3064.61
//
Query:       EFC38310.1  [L=1166]
Description: RGS domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.7e-11   43.8   1.6    1.6e-10   41.3   1.5    2.4  2  RGS         Regulator of G protein signaling domain
      7e-06   26.3   0.0    1.5e-05   25.2   0.0    1.6  1  HAMP        HAMP domain
     0.0046   17.2   0.0      0.013   15.7   0.0    1.8  1  CHASE4      CHASE4 domain
  ------ inclusion threshold ------
       0.43   11.0   2.8        1.3    9.4   0.1    3.1  3  MitMem_reg  Maintenance of mitochondrial structure and functi
          2    8.6   7.4        3.7    7.7   0.5    3.3  2  Fib_alpha   Fibrinogen alpha/beta chain family


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0         2   7.3e+03      46      75 ..     187     216 ..     171     283 .. 0.77
   2 !   41.3   1.5   4.4e-14   1.6e-10       2     109 ..     733     835 ..     732     839 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2
                 HHHHHHHHHHHHTSTTSTTSSTS-HHHHHH CS
         RGS  46 lkkkakeIyneylapsspkelnidkklree 75 
                 +++ a+++ n++l+    ++ ++ +++   
  EFC38310.1 187 TNSNATVLANQFLNYYLHCQYQLTSRVNFA 216
                 556677788888877777777777766554 PP

  == domain 2  score: 41.3 bits;  conditional E-value: 4.4e-14
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeeaqeevfel 100
                 +e+++ ++ gr++F+     e seen+ F++++  +k+ k+ +++ kk  eI+n+yl ++sp  +ni++k+re+  k++ +   + +lf  +++ v ++
  EFC38310.1 733 FERVMMNSNGREMFK-----ECSEENILFLEDILLYKSIKKTSDRAKKQAEILNKYLCDNSPYAINISQKVREKEVKNIAEGYGQIDLFISIEKVVKSM 826
                 566666777777775.....46789********************************************************9***************** PP

                 HHHHHHHHH CS
         RGS 101 lekdsypkF 109
                 l kd + +F
  EFC38310.1 827 LLKDTFLRF 835
                 ******999 PP

>> HAMP  HAMP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.2   0.0   4.3e-09   1.5e-05       6      52 ..     502     549 ..     501     550 .. 0.94

  Alignments for each domain:
  == domain 1  score: 25.2 bits;  conditional E-value: 4.3e-09
                 THHHHHHHHHHHHHHT.TTBTSSTCCTTSSSHHHHHHHHHHHHHHHHH CS
        HAMP   6 ilrPLrrLaraarria.aGdldtrlpvsgrDEiGeLarafNaMldrLr 52 
                 +l++L +L+ a+r i  + ++++r+p  g DE+G+L + +N+Mld+L 
  EFC38310.1 502 VLKRLLKLTNAVRIITnSTNIKERVPNVGSDELGMLCEDVNNMLDALD 549
                 689*************558***************************96 PP

>> CHASE4  CHASE4 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   3.7e-06     0.013      91     135 ..     302     348 ..     160     350 .. 0.63

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3.7e-06
      CHASE4  91 p...alvaaapIltsegegpsrGtlvfgryldeallsrlseltlldle 135
                 +   +l++a+pI +++  ++  G+++fgry ++++  ++s++++ +l+
  EFC38310.1 302 LlnlLLLSAMPIQDTD-YQKTYGIMIFGRYQTREFFTDMSDRSQYCLT 348
                 14559*******8876.5699***********************9987 PP

>> MitMem_reg  Maintenance of mitochondrial structure and function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0         3   1.1e+04      66      91 ..     399     422 ..     365     425 .. 0.56
   2 ?   -0.7   0.1       0.5   1.8e+03      67      67 ..     585     585 ..     510     634 .. 0.51
   3 ?    9.4   0.1   0.00037       1.3      29      80 ..     638     687 ..     627     724 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3
  MitMem_reg  66 qkllnllPhleteelekefnvetnDv 91 
                 +++   l   +t ++ ++f+v  nD+
  EFC38310.1 399 SSQS--LWSNNTGQFIQQFSVDENDL 422
                 3333..33334556777777777776 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.5
  MitMem_reg  67 k 67 
                 +
  EFC38310.1 585 D 585
                 1 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00037
  MitMem_reg  29 qyyslkilqerldlikdYlkkveegelpvnheilrnlqkllnllP.hleteel 80 
                  y+s++  +   d+i +Yl++ +e +  ++++il nl++ +   P  ++t+++
  EFC38310.1 638 LYNSIENPNHLNDEILKYLENMAETKSRWDTTILSNLGSEI---PvSVSTSKV 687
                 79999999999***************************999...866666443 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.5     0.001       3.7       7      73 ..     529     595 ..     523     647 .. 0.79
   2 ?    2.1   1.9     0.058   2.1e+02      76     120 ..     681     726 ..     628     732 .. 0.54

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.001
                 TCCCCCEEEEE-CCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha   7 ildeefgslCPtgCglqdlllkyekdvkkdlekleneleeisnstkeaeelvkeikdslrekqkskk 73 
                 + ++e+g+lC    ++ d+l+ +++ +++d e +++ le+ s s+++++ ++++i+d + +  ++++
  EFC38310.1 529 VGSDELGMLCEDVNNMLDALDATQTILSEDNELMQRLLEKTSLSEQKSRVIMNSIDDFIFSVDSKTA 595
                 6789***************************************************998766555444 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.058
                 HHHHHHHHHHHHH.CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH CS
   Fib_alpha  76 dnvikksskelee.eilrlketidaqesnirvLqnvlesneqkiqk 120
                 +  ++k+  +l+e +i ++   + +++s+  +L++ ++ +eq++q+
  EFC38310.1 681 SVSTSKVDIMLDEgNIHQVYVIVARNMSEQVELRQAVKVQEQRMQD 726
                 3445555555554244555555555666666667777777776666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1212  (0.0676); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.96u 0.33s 00:00:01.29 Elapsed: 00:00:00.53
# Mc/sec: 6614.55
//
Query:       EFC38311.1  [L=883]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-94  313.2   0.5    6.1e-48  162.6   0.0    3.1  3  AAA              ATPase family associated with various cellul
    1.4e-27   95.2   0.1    1.4e-13   50.4   0.1    3.1  2  AAA_lid_3        AAA+ lid domain
      1e-14   54.6   0.0    4.8e-07   29.7   0.0    2.7  2  RuvB_N           Holliday junction DNA helicase RuvB P-loop d
    1.1e-13   51.6   0.0    2.2e-05   24.6   0.0    3.1  2  AAA_2            AAA domain (Cdc48 subfamily)
    2.2e-13   50.9   0.7    0.00035   21.0   0.0    5.0  3  AAA_16           AAA ATPase domain
    2.9e-11   43.8   4.0     0.0098   16.2   0.0    5.7  5  AAA_22           AAA domain
      3e-11   43.1   0.1    6.8e-06   25.5   0.0    2.6  2  TIP49            TIP49 P-loop domain
    1.9e-10   40.9   2.0    0.00077   19.5   0.0    4.1  2  AAA_5            AAA domain (dynein-related subfamily)
    8.9e-10   38.4   0.1    0.00018   21.4   0.0    3.1  2  Vps4_C           Vps4 C terminal oligomerisation domain
    2.1e-09   37.7   0.0      0.001   19.3   0.0    3.1  2  AAA_33           AAA domain
    3.2e-09   36.9   0.0     0.0016   18.4   0.0    3.3  2  AAA_14           AAA domain
    3.5e-09   37.0   0.0     0.0064   16.9   0.0    3.3  2  RNA_helicase     RNA helicase
    4.1e-08   33.8   0.3     0.0098   16.4   0.0    3.5  3  AAA_18           AAA domain
    5.4e-08   32.5   0.2     0.0072   15.7   0.0    2.5  2  Mg_chelatase     Magnesium chelatase, subunit ChlI
    1.4e-07   31.3   1.5        1.4    8.4   0.0    4.7  4  AAA_25           AAA domain
      6e-07   29.5   0.2      0.015   15.2   0.0    3.5  3  NACHT            NACHT domain
    1.2e-06   28.9   0.0       0.05   13.9   0.0    3.1  2  AAA_28           AAA domain
      2e-06   27.7   0.0      0.077   12.7   0.0    2.6  2  IstB_IS21        IstB-like ATP binding protein
    4.4e-06   26.7   0.0       0.16   11.9   0.0    2.7  2  TsaE             Threonylcarbamoyl adenosine biosynthesis pro
    4.6e-06   27.2   6.7      0.023   15.2   0.0    4.2  2  ABC_tran         ABC transporter
      1e-05   24.9   0.1        0.2   10.9   0.0    2.7  2  Zeta_toxin       Zeta toxin
      2e-05   24.6   0.3       0.38   10.6   0.0    3.6  3  Rad17            Rad17 P-loop domain
      3e-05   23.3   0.1       0.23   10.6   0.0    3.1  3  NB-ARC           NB-ARC domain
    6.8e-05   22.6   0.0       0.23   11.2   0.0    3.4  3  Sigma54_activat  Sigma-54 interaction domain
    0.00011   22.2   7.9       0.79    9.6   0.0    5.0  4  ATPase_2         ATPase domain predominantly from Archaea
    0.00026   20.8   0.0       0.39   10.4   0.0    2.7  2  AAA_24           AAA domain
    0.00029   21.0   0.2       0.04   14.1   0.0    3.0  3  Cytidylate_kin2  Cytidylate kinase-like family
    0.00029   20.7   0.0       0.74    9.7   0.0    2.8  2  AAA_3            ATPase family associated with various cellul
    0.00042   20.1   3.4          1    9.1   0.0    3.4  2  Viral_helicase1  Viral (Superfamily 1) RNA helicase
    0.00045   19.4   0.1       0.94    8.5   0.0    2.5  2  Parvo_NS1        Parvovirus non-structural protein NS1
     0.0009   18.8   0.2        1.6    8.2   0.0    3.1  2  AAA_7            P-loop containing dynein motor region
      0.001   18.5   3.3       0.93    8.8   0.0    3.8  4  ATPase           KaiC
     0.0018   17.0  12.9     0.0018   17.0  12.9    1.9  2  Macoilin         Macoilin family
     0.0061   15.8   0.0          1    8.5   0.0    3.0  2  DUF815           Protein of unknown function (DUF815)
     0.0062   16.3   0.0        5.1    6.8   0.0    2.7  2  PduV-EutP        Ethanolamine utilisation - propanediol utili
     0.0067   16.3   0.0        5.2    6.8   0.0    2.7  2  Bac_DnaA         Bacterial dnaA  protein
     0.0067   16.5   0.0       0.67   10.1   0.0    2.6  2  Sigma54_activ_2  Sigma-54 interaction domain
     0.0069   16.3   0.7         11    5.9   0.0    4.3  4  NTPase_1         NTPase
     0.0076   16.1   0.0       0.57   10.0   0.0    2.5  2  CPT              Chloramphenicol phosphotransferase-like prot
  ------ inclusion threshold ------
      0.011   16.2  12.5       0.29   11.5   0.0    4.6  3  AAA_17           AAA domain
      0.021   13.7   0.0       0.63    8.9   0.0    2.6  2  AFG1_ATPase      AFG1-like ATPase
      0.029   14.0   0.5       0.27   10.9   0.0    2.5  2  Nucleolin_bd     Nucleolin binding domain
      0.032   13.7   0.4         10    5.5   0.0    2.5  2  PhoH             PhoH-like protein
      0.056   13.6   1.8        9.1    6.4   0.0    3.3  3  SKI              Shikimate kinase
      0.065   13.3   0.1         12    6.0   0.0    3.5  3  MMR_HSR1         50S ribosome-binding GTPase
       0.14   12.5   1.1         18    5.7   0.1    2.8  2  AAA_19           AAA domain
       0.63    9.5   3.7        3.7    7.1   0.0    3.0  3  FeoB_N           Ferrous iron transport protein B
        3.7    5.8  14.1          7    4.9  14.1    1.4  1  Menin            Menin
        5.2    7.3  22.8        6.1    7.1   0.0    4.0  3  Hydin_ADK        Hydin Adenylate kinase-like domain


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.2       6.7   2.4e+03      67     100 ..      78     111 ..      70     126 .. 0.76
   2 !  147.2   0.0   9.8e-46   3.6e-43       1     130 [.     262     394 ..     262     396 .. 0.97
   3 !  162.6   0.0   1.7e-50   6.1e-48       1     131 [.     589     719 ..     589     720 .. 0.97

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 6.7
                 GGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSS CS
         AAA  67 idalaksrsgseseeeervvnqLlteldgvkkke 100
                 id+l +++++s+seee+   ++L + +++v k +
  EFC38311.1  78 IDRLLGEDESSSSEEEQISKEELEKRMQKVAKLK 111
                 7888888877777888888888888888877753 PP

  == domain 2  score: 147.2 bits;  conditional E-value: 9.8e-46
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTS CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkk 99 
                 +ll+GppG+GKT+la+a+a el+++fl++s++e++s + gese+kir++f++a ++a psi+fiDEida+ ++r+++++e e+r+v+qL+t ld+++ +
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQIPFLKVSAPEIVSGMSGESEAKIRQIFRDAISNA-PSIIFIDEIDAILSKRDNASKEMEKRIVAQLITCLDDLTLE 359
                 69******************************************************9.**************************************999 PP

                 ...SSTEEEEEEESSGGGSTHHHHS.TTSSEEEET CS
         AAA 100 ...eskvivigatnrpdkldpallr.gRfdrkiei 130
                     ++vi+igatnrpd+ld+al+r gRfdr+i +
  EFC38311.1 360 ktgGKTVIIIGATNRPDSLDDALRRaGRFDREISL 394
                 899677*************************9976 PP

  == domain 3  score: 162.6 bits;  conditional E-value: 1.7e-50
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH.TTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksr.sgseseeeervvnqLlteldgvkk 98 
                 vllyGppG+GKTllaka+ +++g++f++i+g+ell+kyvgese+ +r++f++a +++ p+++f+DE+dal+++r ++s+s+++ervvnqLlt++dg+++
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGANFISIKGPELLNKYVGESERAVRQVFSRAAASS-PCVIFFDEMDALCPKRdNESSSQSSERVVNQLLTAMDGLES 686
                 79***************************************************9998.****************88889******************** PP

                 SSSTEEEEEEESSGGGSTHHHHS.TTSSEEEETT CS
         AAA  99 keskvivigatnrpdkldpallr.gRfdrkieie 131
                 + + v+vi+atnrpd++d+a+lr gR+d+ ++++
  EFC38311.1 687 R-GMVFVIAATNRPDMIDSAMLRpGRLDKLLYVK 719
                 7.66*************************99886 PP

>> AAA_lid_3  AAA+ lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.4   0.0   2.5e-13   9.2e-11       2      35 ..     422     455 ..     421     465 .. 0.92
   2 !   50.4   0.1   3.9e-16   1.4e-13       1      44 [.     742     801 ..     742     802 .. 0.80

  Alignments for each domain:
  == domain 1  score: 41.4 bits;  conditional E-value: 2.5e-13
   AAA_lid_3   2 vdlkeLAerTeGySGADlaalcreAallAlrrgi 35 
                 +d+k +A  T+Gy+GADl+al++eAa++A+ r +
  EFC38311.1 422 FDFKTIAHNTPGYVGADLKALVNEAAIAAIHRIF 455
                 69****************************9965 PP

  == domain 2  score: 50.4 bits;  conditional E-value: 3.9e-16
   AAA_lid_3   1 dvdlkeLAerTeGySGADlaalcreAallAlrr................gikeitmedfe 44 
                 dv+l+e+A+++e++SGADlaal+reAa  +l++                g+  +t e+f+
  EFC38311.1 742 DVNLEEIAKLCENFSGADLAALVREAATSCLKEhllkgrsntntpnkaiGEMIVTREHFK 801
                 9********************************666666666666554444457777775 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.0   1.3e-09   4.8e-07      35     150 ..     261     383 ..     255     393 .. 0.76
   2 !   21.8   0.0   3.3e-07   0.00012      34      70 ..     587     623 ..     549     663 .. 0.81

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 1.3e-09
      RuvB_N  35 hvllyGpPGlGkttlakiiakelgvklkitsgPvl......ekagdlaalltnl..eekdvlfideihrlsraveevlysamedfrldivigkGpsars 125
                  +ll+GpPG Gkt la+ ia el++ +   s+P +      e ++ +  ++ +   ++  ++fidei  + ++ ++   + me   +  +i      + 
  EFC38311.1 261 GILLHGPPGCGKTMLANAIAGELQIPFLKVSAPEIvsgmsgESEAKIRQIFRDAisNAPSIIFIDEIDAILSKRDNA-SKEMEKRIVAQLITCLDDLTL 358
                 58******************************99844333334555666665532244589*******998877665.567888888888888777777 PP

      RuvB_N 126 ikldlpkftlvgattragllssPlr 150
                  k   +   ++gat r   l   lr
  EFC38311.1 359 EKTGGKTVIIIGATNRPDSLDDALR 383
                 8888888888888888888888777 PP

  == domain 2  score: 21.8 bits;  conditional E-value: 3.3e-07
      RuvB_N  34 dhvllyGpPGlGkttlakiiakelgvklkitsgPvle 70 
                   vllyGpPG Gkt lak i+++ g+++ +  gP l 
  EFC38311.1 587 AGVLLYGPPGCGKTLLAKAISNDSGANFISIKGPELL 623
                 569***************************9999864 PP

>> AAA_2  AAA domain (Cdc48 subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.0   1.8e-07   6.7e-05       6     127 ..     262     372 ..     258     407 .. 0.77
   2 !   24.6   0.0     6e-08   2.2e-05       6     105 ..     589     683 ..     586     687 .. 0.82

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.8e-07
                 EEEE--TTSSHHHHHHHHHHHTT-....-EEEEEGGG-------THHHHHHHHHTTT-HHHHTTSEEEEETGGG----.---------HHHHHHHHHHH CS
       AAA_2   6 illlgptgvGktelakalaellfvkkekkliradaselleeeevehlvsrligappgyvgaeegGivllDEidKihpk.essgadvSregVqrdLLqil 103
                 ill gp g+Gkt+la+a+a  l++    ++  + a e+  +   e+  +  ++ ++++ +a    i+++DEid i +k ++++++  ++ ++  L   l
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQI----PFLKVSAPEIVSGMSGESEAKIRQIFRDAISNA--PSIIFIDEIDAILSKrDNASKE-MEKRIVAQLITCL 353
                 8999*******************9....999999999999555555555555555555543..45************84444444.4456777889999 PP

                 H--EE-------EE-TT-EEEEEE CS
       AAA_2 104 eggtltdkqgrkvdtknilfImtg 127
                 ++ tl++  g     k +++I ++
  EFC38311.1 354 DDLTLEKTGG-----KTVIIIGAT 372
                 **99999999.....445555555 PP

  == domain 2  score: 24.6 bits;  conditional E-value: 6e-08
                 EEEE--TTSSHHHHHHHHHHHTT-....-EEEEEGGG-------THHHHHHHHH.TTT-HHHHTTS..EEEEETGGG----.---------HHHHHHHH CS
       AAA_2   6 illlgptgvGktelakalaellfvkkekkliradaselleeeevehlvsrliga.ppgyvgaeegG..ivllDEidKihpk.essgadvSregVqrdLL 100
                 +ll gp g+Gkt+laka+++   +    ++i +   ell      ++v + + a ++   +a+ +   ++++DE+d  +pk +++++  S+e V++ LL
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGA----NFISIKGPELLN-----KYVGESERAvRQVFSRAAASSpcVIFFDEMDALCPKrDNESSSQSSERVVNQLL 678
                 6899*************9998885....************.....55555544404444444444478*************99999999********** PP

                 HHHH- CS
       AAA_2 101 qileg 105
                   ++g
  EFC38311.1 679 TAMDG 683
                 99997 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0       3.1   1.1e+03      60     126 ..      58     128 ..      24     136 .. 0.60
   2 !   20.1   0.1   1.8e-06   0.00065      24     130 ..     259     356 ..     249     379 .. 0.60
   3 !   21.0   0.0   9.5e-07   0.00035      23      88 ..     585     653 ..     576     693 .. 0.55

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 3.1
      AAA_16  60 cdqlesaipysalaqalareellrqlldeaesaeleawrekleeala.......avpelagaeasrllellkrl 126
                  ++  ++ip++ + +++     +  ll e+es++ e+ +   +e+l+         +e+   e+++++++l++ 
  EFC38311.1  58 HEKDYKQIPLLDFKEIC-L-VAIDRLLGEDESSSSEEEQI-SKEELEkrmqkvaKLKEVINNEKTSMNYQLQNV 128
                 44444668888888888.5.67777777766644444443.444444344444444444444447777777765 PP

  == domain 2  score: 20.1 bits;  conditional E-value: 1.8e-06
      AAA_16  24 pelvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysa.laqalareellrqlldeaesaeleawrekleealaavpelagaeasrlle 121
                 p+ +ll+G++G+GK+ l+++++ +l+     fl+  + +  s+  +s      + r +++r+  ++   a    + +++++ l+  ++++ + ++r+ +
  EFC38311.1 259 PRGILLHGPPGCGKTMLANAIAGELQIP---FLKVSAPEIVSG--MSGeSEAKI-R-QIFRDAISN---APSIIFIDEIDAILSKRDNASKEMEKRIVA 347
                 499*******************988877...666666666222..122122222.2.333333333...233444455555555555666666677777 PP

      AAA_16 122 llkrllall 130
                 +l  +l+ l
  EFC38311.1 348 QLITCLDDL 356
                 777777433 PP

  == domain 3  score: 21.0 bits;  conditional E-value: 9.5e-07
      AAA_16  23 rpelvllsGesGvGKsslvrellralekdggiflrgkcdql......esaipysa.laqalareellrqllde 88 
                  p  vll+G++G+GK+ l++++ +   ++   f++ k  +l      es+++  + + +a+ +++ +    de
  EFC38311.1 585 APAGVLLYGPPGCGKTLLAKAISNDSGAN---FISIKGPELlnkyvgESERAVRQvFSRAA-ASSPCVIFFDE 653
                 5678*******************866655...88888877744555444444433344444.33555544444 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   2.7e-05    0.0098       8      42 ..     262     287 ..     257     317 .. 0.72
   2 !    8.2   0.0    0.0076       2.8      74     131 ..     303     372 ..     292     378 .. 0.74
   3 !   11.7   0.0   0.00066      0.24       9      27 ..     590     608 ..     586     623 .. 0.84
   4 ?    4.0   0.0      0.15        56      81     127 ..     633     693 ..     621     700 .. 0.65
   5 ?   -1.7   0.0       8.7   3.2e+03      41      70 ..     714     743 ..     704     777 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 2.7e-05
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaeeerpev 42 
                 ++++G++G+GKT+l++ ++ +l+          ++
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQ---------IPF 287
                 89****************99994.........333 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0076
      AAA_22  74 sseellealeqalraravielliiDEaqh.lr...s......eealeeLrsllnl....srkgvqliLvGtp 131
                 s+  +++ +++a++++    ++ iDE++  l+   +      ++++ +L ++l++    ++ g ++i++G +
  EFC38311.1 303 SEAKIRQIFRDAISNAPS--IIFIDEIDAiLSkrdNaskemeKRIVAQLITCLDDltleKTGGKTVIIIGAT 372
                 555666777777777766..*********6657551566677888888899999899977777778888876 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 0.00066
      AAA_22   9 vvtGesGtGKTtllrrlle 27 
                 +++G++G+GKT+l++ + +
  EFC38311.1 590 LLYGPPGCGKTLLAKAISN 608
                 79************99876 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.15
      AAA_22  81 aleqalrarav..ielliiDEaqhlr.......s....eealeeLrsllnl.srkgvqliL 127
                 a++q ++++a+  + ++  DE++ l        s    e+++++L + ++  ++ g+ +++
  EFC38311.1 633 AVRQVFSRAAAssPCVIFFDEMDALCpkrdnesSsqssERVVNQLLTAMDGlESRGMVFVI 693
                 444444455555679**********776555541455677777776666655555555555 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 8.7
      AAA_22  41 evvfvtlpsstsskdllrellralglelka 70 
                 ++++v+lp++ ++ ++l+ ++r++ l  + 
  EFC38311.1 714 KLLYVKLPNEQERISVLKTIARKTPLASDV 743
                 567999999999999999999988765554 PP

>> TIP49  TIP49 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.5   0.0   1.9e-08   6.8e-06      51     107 ..     260     315 ..     257     350 .. 0.93
   2 !   14.7   0.0   3.7e-05     0.014      51     105 ..     587     640 ..     578     643 .. 0.83

  Alignments for each domain:
  == domain 1  score: 25.5 bits;  conditional E-value: 1.9e-08
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXX CS
       TIP49  51 ravLlaGpsgtGktalaiaiskelgedvpfvalsgsevyslevkktev.ltqalrksi 107
                 r++Ll Gp+g Gkt la ai+ el   +pf ++s+ e+ s     +e+ + q +r +i
  EFC38311.1 260 RGILLHGPPGCGKTMLANAIAGELQ--IPFLKVSAPEIVSGMSGESEAkIRQIFRDAI 315
                 89**********************7..**************99999985778999998 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 3.7e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXX CS
       TIP49  51 ravLlaGpsgtGktalaiaiskelgedvpfvalsgsevyslevkkte.vltqalrk 105
                  +vLl Gp+g Gkt la ais++ g    f++++g e+    v  +e ++ q + +
  EFC38311.1 587 AGVLLYGPPGCGKTLLAKAISNDSG--ANFISIKGPELLNKYVGESErAVRQVFSR 640
                 589*******************988..78********9999988887345566655 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   2.1e-06   0.00077       2     135 ..     262     383 ..     261     385 .. 0.65
   2 !   17.8   0.0   6.9e-06    0.0025       1      79 [.     588     659 ..     588     709 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 2.1e-06
                 EEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--.........--------.G-SEEEEESGGG--HH...HHHHHHHHHHSSEEE. CS
       AAA_5   2 vlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraar.egeilvlDEveraese...vlnsLlslleerrlll 96 
                 +lL GppG+gK++la  +a  l+ +++ v  ++      ++ +++  ++ ++   +++ +a+   ++i+++DE++ + s+   + +++ + +  + +  
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQIPFLKVSAPE------IVSGMS--GESEAKIRQIFRDAISnAPSIIFIDEIDAILSKrdnASKEMEKRIVAQLITC 352
                 89********************99999886665......888888..566677777788777778899*****99765430002333322233333333 PP

                 .-SSSEEE---..........-EEEEEESS--.-TT-TTHHHH CS
       AAA_5  97 eeggelvkaknddller....frviatanpldrslnelspalr 135
                  +  +l+k        +    + +i+++n++d    +l+ alr
  EFC38311.1 353 LDDLTLEK--------TggktVIIIGATNRPD----SLDDALR 383
                 33333333........1444477888888877....6666666 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 6.9e-06
                 EEEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHHH--B--.........--------.G-SEEEEESGGG--H CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnreveyvqltrdtteedlkgrreikngttslvdsplvraar.egeilvlDEveraes 79 
                 +vlL GppG+gK+ la+ ++   ++++  + +++      l+ ++   ++ ++ v +++ raa  +++++++DE + + +
  EFC38311.1 588 GVLLYGPPGCGKTLLAKAISNDSGANFISIKGPE------LLNKYV--GESERAVRQVFSRAAAsSPCVIFFDEMDALCP 659
                 59******************99999999999887......555555..45556678888887777889999999886655 PP

>> Vps4_C  Vps4 C terminal oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   0.00017     0.062      19      45 ..     512     538 ..     502     543 .. 0.85
   2 !   21.4   0.0     5e-07   0.00018      20      55 ..     786     821 ..     780     824 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 0.00017
      Vps4_C  19 ipsdkllePpvtlkDflkalkkarptV 45 
                 +++++l +  vt++Df+ka+kk++p+ 
  EFC38311.1 512 LTEQQLANLYVTFNDFEKAIKKVQPSA 538
                 668899999****************96 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 5e-07
      Vps4_C  20 psdkllePpvtlkDflkalkkarptVskeDLekhee 55 
                 p + + e  vt+++f+ alkk  p+Vs++DL+ +e+
  EFC38311.1 786 PNKAIGEMIVTREHFKIALKKIPPSVSSKDLKIYEK 821
                 667788999***********************9997 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   2.7e-06     0.001       2      80 ..     262     374 ..     262     399 .. 0.60
   2 !   14.9   0.0   6.1e-05     0.022       2      80 ..     589     698 ..     589     732 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 2.7e-06
      AAA_33   2 vllvGlpGsGKstlaerllkklg..avllssdtlrrrlfgtdqqskt................................dytrvldrlyqilnelarka 66 
                 +ll+G+pG+GK+ la  ++ +l+  +  +s +++ + + g+ + +++                                  +r+  +l+ +l +l  ++
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQipFLKVSAPEIVSGMSGESEAKIRqifrdaisnapsiifideidailskrdnaskeMEKRIVAQLITCLDDLTLEK 360
                 689********************8777799999666666644444433333333333333333333333333333222255566666777776666554 PP

      AAA_33  67 lsagrnvildatnl 80 
                    +  +i+ atn+
  EFC38311.1 361 TGGKTVIIIGATNR 374
                 44444455566654 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 6.1e-05
      AAA_33   2 vllvGlpGsGKstlaerllkklg..avllssdt...............................lrrrlfgtdqqskt....dytrvldrlyqilnela 63 
                 vll G+pG+GK+ la+ + +  g  ++ +  ++                               ++++l++      +     +++ ++r+ ++l    
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGanFISIKGPEllnkyvgeseravrqvfsraaasspcviffdEMDALCP------KrdneSSSQSSERVVNQLLTAM 681
                 7899***************9999776667777744444466666555555555555555555555555554......0322233445566666666666 PP

      AAA_33  64 rkalsagrnvildatnl 80 
                 +   s+g  +++ atn+
  EFC38311.1 682 DGLESRGMVFVIAATNR 698
                 66667777777777775 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   4.5e-06    0.0016       5      76 ..     262     330 ..     259     387 .. 0.73
   2 !   14.3   0.0   8.2e-05      0.03       5      77 ..     589     668 ..     586     716 .. 0.73

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 4.5e-06
      AAA_14   5 lvitGaRrvGKTtllkqlikellvkkesilyinldderd..kkladpe.kllelileklkeekktylflDEiqev 76 
                 +++ G+  +GKT+l++ ++ el      i ++++  ++    ++ ++e k+ +++++ +++   +++f+DEi  +
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQ-----IPFLKVSAPEIvsGMSGESEaKIRQIFRDAISN-APSIIFIDEIDAI 330
                 6899***********99998877.....555555555553233333333677888888877.89********988 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 8.2e-05
      AAA_14   5 lvitGaRrvGKTtllkqlikellvkkesilyinldderdkkladpekllelileklkeekktylflDEiqev..........p 77 
                 +++ G+  +GKT l+k + +++     +++ i+  +  +k   ++e+  + +++++ ++   ++f+DE+  +          +
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSG---ANFISIKGPELLNKYVGESERAVRQVFSRAAASSPCVIFFDEMDALcpkrdnesssQ 668
                 6899**********999998888...8899888888888776666655655555544458999*****987766666666553 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.6e-05    0.0094       1      38 [.     262     299 ..     262     364 .. 0.64
   2 !   16.9   0.0   1.7e-05    0.0064       1      94 [.     589     689 ..     589     698 .. 0.61

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.6e-05
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkklklkkkdsvysrn 38 
                   i+l+Gp+g+GK++la+ +a +l+  + + ++++++s+ 
    EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQIPFLKVSAPEIVSGM 299
                   689****************9999766444455555433 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 1.7e-05
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkkl......klkkkdsvys.rnpeddfwdgYtgqevvvidDfgqvk.dee.npsdlaelirlvsstpyplnmas 88 
                   ++lyGp+g+GK++lak ++++   ++      +l +k    s r++++ f     + ++v+++D +     +  n+s  +   r+v+  ++ + m+ 
    EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGANFisikgpELLNKYVGESeRAVRQVFSRAAASSPCVIFFDEMDALcPKRdNESSSQSSERVVN--QLLTAMDG 683
                   689**************9999998777776664444344444456666666666677777776644433133334444444444443..45566666 PP

  RNA_helicase  89 leekgt 94 
                   le+ g+
    EFC38311.1 684 LESRGM 689
                   666654 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.3         6   2.2e+03      47      92 ..      93     134 ..      50     161 .. 0.52
   2 !   16.4   0.0   2.7e-05    0.0098       1      81 [.     262     370 ..     262     405 .. 0.72
   3 !   13.0   0.0    0.0003      0.11       1      30 [.     589     616 ..     589     698 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 6
      AAA_18  47 deskrldedkldklldaleenssaleegknlvidghlaeleseaak 92 
                 ++  +++ +k+++ + +l+e ++    ++   +  +l++ ++e+ +
  EFC38311.1  93 EQISKEELEKRMQKVAKLKEVIN----NEKTSMNYQLQNVYKEQST 134
                 33444444444555555555443....3444555555555555554 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 2.7e-05
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf..................gvnlrdvakenglllevdpe..........aldeskrldedkldklldaleenssal 71 
                 Ill G+pG+GKt la++++ +l++                    ++r+++++  +  +   +            + sk++++  +++l+++l+      
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQIpflkvsapeivsgmsgesEAKIRQIFRDAISNAPSIIFideidailskRDNASKEMEKRIVAQLITCLDDLTLEK 360
                 89****************999888889999999999999999555555555555555555554445666876666788899999999999999988766 PP

      AAA_18  72 eegknlvidg 81 
                 + gk+++i g
  EFC38311.1 361 TGGKTVIIIG 370
                 6666666544 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 0.0003
      AAA_18   1 IlltGtpGvGKttlakeLskrlgfgvnlrd 30 
                 +ll G+pG+GKt lak++s+    g n ++
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDS--GANFIS 616
                 799***************8876..444433 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0     2e-05    0.0072      25      44 ..     262     281 ..     259     315 .. 0.84
   2 !   14.1   0.0   6.2e-05     0.023      25      43 ..     589     607 ..     569     608 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 2e-05
  Mg_chelatase  25 lllvGppGsGKtmlakrlps 44 
                   +ll GppG+GKtmla+++++
    EFC38311.1 262 ILLHGPPGCGKTMLANAIAG 281
                   89**************9976 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 6.2e-05
  Mg_chelatase  25 lllvGppGsGKtmlakrlp 43 
                   +ll+GppG+GKt+lak+++
    EFC38311.1 589 VLLYGPPGCGKTLLAKAIS 607
                   89**************985 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0041       1.5      36      54 ..     262     280 ..     259     284 .. 0.87
   2 ?    6.5   0.1     0.016       5.7     127     175 ..     304     356 ..     284     374 .. 0.75
   3 !    8.4   0.0    0.0039       1.4      35      50 ..     588     603 ..     561     609 .. 0.82
   4 ?    2.9   0.0      0.19        70     128     173 ..     632     678 ..     616     696 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0041
      AAA_25  36 allaGapgtGKttlaldla 54 
                 +ll G+pg+GKt+la  +a
  EFC38311.1 262 ILLHGPPGCGKTMLANAIA 280
                 689***********97665 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.016
      AAA_25 127 tadvdaleaaieevegvrlvviDplsralggdensnsd.....vgalvealeri 175
                 +a+++++ +++ + + +  + iD ++++l+   n++++     v++l+++l+++
  EFC38311.1 304 EAKIRQIFRDAIS-NAPSIIFIDEIDAILSKRDNASKEmekriVAQLITCLDDL 356
                 5789999999999.77***************99999994444335555555555 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0039
      AAA_25  35 lallaGapgtGKttla 50 
                  +ll+G+pg+GKt la
  EFC38311.1 588 GVLLYGPPGCGKTLLA 603
                 579***********98 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.19
      AAA_25 128 advdaleaaieevegvrlvviDplsralgg.densnsdv.galveale 173
                 ++v+++  ++ +   + ++ +D ++++++  d++s+s+  +++v++l 
  EFC38311.1 632 RAVRQVFSRAAA-SSPCVIFFDEMDALCPKrDNESSSQSsERVVNQLL 678
                 567777778888.6799*************988888885577777764 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   4.1e-05     0.015       3      25 ..     262     284 ..     260     291 .. 0.89
   2 !    9.8   0.0     0.002      0.72       3      22 ..     589     608 ..     588     613 .. 0.89
   3 ?   -1.1   0.0       4.3   1.6e+03      60     115 ..     625     680 ..     620     701 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 4.1e-05
                 EEEEC-TTTCHHHHHHHHHHHHC CS
       NACHT   3 vilqGeaGsGKTtLlqklalawa 25 
                 ++l+G++G+GKT+L+  +a +++
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQ 284
                 89****************98775 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.002
                 EEEEC-TTTCHHHHHHHHHH CS
       NACHT   3 vilqGeaGsGKTtLlqklal 22 
                 v+l G++G+GKT L++ +  
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISN 608
                 789*************9975 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 4.3
                 CCCTS--SSS-CCHHHHCCSCCCEEEEEE-STT-SS-TCH..........HHHHHCT CS
       NACHT  60 sqlpepaapvsevwavllelperlLlilDglDelvtdlgq.kekqpvrtlLselirk 115
                 +   e++++v++v+  +++     ++ +D +D l+ + ++ +  q+++++ ++l+++
  EFC38311.1 625 KYVGESERAVRQVF-SRAAASSPCVIFFDEMDALCPKRDNeSSSQSSERVVNQLLTA 680
                 55566677777744.455666777788999999988777766777777777777764 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.0   0.00014      0.05       2      52 ..     262     314 ..     261     332 .. 0.79
   2 !   11.6   0.0   0.00069      0.25       2      35 ..     589     627 ..     588     657 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 0.00014
      AAA_28   2 ivitGgestGKTtlleaLaar.gypvvpEaareileeklakgedalpwv.edl 52 
                 i + G++++GKT l++a+a + ++p ++ +a ei++  + + e ++++  +d+
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGElQIPFLKVSAPEIVSGMSGESEAKIRQIfRDA 314
                 7899***************6659998888888887777766666666655555 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00069
      AAA_28   2 ivitGgestGKTtlleaLaar.gypvv....pEaareil 35 
                 + + G++++GKT l++a++++ g + +    pE   +++
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDsGANFIsikgPELLNKYV 627
                 6799***************87754443224566655555 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.0   0.00021     0.077      48      70 ..     260     282 ..     249     352 .. 0.81
   2 !   12.2   0.0   0.00031      0.11      48      70 ..     587     609 ..     582     626 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 0.00021
   IstB_IS21  48 enivllGpsGvGKshlaialgve 70 
                  +i+l Gp+G GK+ la a++ e
  EFC38311.1 260 RGILLHGPPGCGKTMLANAIAGE 282
                 5799***************9865 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00031
   IstB_IS21  48 enivllGpsGvGKshlaialgve 70 
                 ++++l Gp+G GK+ la a++ +
  EFC38311.1 587 AGVLLYGPPGCGKTLLAKAISND 609
                 6899***************9876 PP

>> TsaE  Threonylcarbamoyl adenosine biosynthesis protein TsaE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.0   0.00045      0.16      21      51 ..     261     293 ..     236     296 .. 0.84
   2 !   11.6   0.0   0.00056      0.21      19      60 ..     586     627 ..     558     637 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00045
                 EEEEEESTTSSHHHHHHHHHHHTT--..----T CS
        TsaE  21 vilLeGdLGaGKTtlvrglakalgve..evkSP 51 
                  ilL+G+ G+GKT+l+ ++a +l++   +v+ P
  EFC38311.1 261 GILLHGPPGCGKTMLANAIAGELQIPflKVSAP 293
                 49*********************9988888877 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00056
                 TEEEEEEESTTSSHHHHHHHHHHHTT--..----TTTTSEEEEE CS
        TsaE  19 gdvilLeGdLGaGKTtlvrglakalgve..evkSPTFtlveeYe 60 
                  + +lL+G+ G+GKT l++++ +  g +  ++k P   l+++Y 
  EFC38311.1 586 PAGVLLYGPPGCGKTLLAKAISNDSGANfiSIKGP--ELLNKYV 627
                 3359*******************999988888888..5667765 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   6.3e-05     0.023       6      37 ..     254     285 ..     252     415 .. 0.77
   2 !   11.6   0.0   0.00084      0.31      13      36 ..     588     611 ..     579     686 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 6.3e-05
                 EEEETTSEEEEEESTTSSHHHHHHHHTTSS-- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   6 lklkegekvaivGenGaGKStLlkllagllkp 37 
                 l +++ + + + G+ G+GK+ L++++ag+l+ 
  EFC38311.1 254 LGVEPPRGILLHGPPGCGKTMLANAIAGELQI 285
                 66777778899*****************9875 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00084
                 EEEEEESTTSSHHHHHHHHTTSS- CS
                 xxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  13 kvaivGenGaGKStLlkllagllk 36 
                  v + G+ G+GK+ L+k++++ + 
  EFC38311.1 588 GVLLYGPPGCGKTLLAKAISNDSG 611
                 57899**************98764 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.9   0.0   0.00054       0.2      14      41 ..     257     284 ..     250     294 .. 0.87
   2 !   10.9   0.0   0.00056      0.21      15      51 ..     585     619 ..     576     627 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00054
  Zeta_toxin  14 erPklillgGqpGAGKselaellkdele 41 
                 e P  ill G pG+GK+ la++++ el+
  EFC38311.1 257 EPPRGILLHGPPGCGKTMLANAIAGELQ 284
                 568889******************9984 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00056
  Zeta_toxin  15 rPklillgGqpGAGKselaellkdelerqgnvvrldp 51 
                  P+ +ll G pG+GK+ la+++ ++   + n++ +++
  EFC38311.1 585 APAGVLLYGPPGCGKTLLAKAISNDS--GANFISIKG 619
                 6999********************98..899998875 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0    0.0028         1      46      77 ..     260     291 ..     251     314 .. 0.80
   2 !   10.6   0.0     0.001      0.38      48      82 ..     589     623 ..     558     657 .. 0.82
   3 ?   -1.6   0.0       6.1   2.2e+03     152     178 ..     634     657 ..     621     704 .. 0.48

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0028
       Rad17  46 riLLisGPsGCgkstvvkvLskelgiklrewl 77 
                 r +L+ GP+GCgk+   + ++ el i + + +
  EFC38311.1 260 RGILLHGPPGCGKTMLANAIAGELQIPFLKVS 291
                 55799*********999999999887666555 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.001
       Rad17  48 LLisGPsGCgkstvvkvLskelgiklrewlnpvsl 82 
                 +L+ GP+GCgk+   k +s   g +++    p +l
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGANFISIKGPELL 623
                 5899****************999999887777665 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 6.1
       Rad17 152 lrevirkylrssealplilviteiesl 178
                 +r+v  ++  ss +   ++   e++ l
  EFC38311.1 634 VRQVFSRAAASSPC---VIFFDEMDAL 657
                 55555554444444...3333333322 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0    0.0023      0.84      23      43 ..     262     282 ..     250     292 .. 0.88
   2 ?   -2.2   0.0       5.2   1.9e+03      42      42 ..     373     373 ..     294     421 .. 0.58
   3 !   10.6   0.0   0.00064      0.23      23      44 ..     589     610 ..     580     616 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0023
                 EEEEESTTSSHHHHHHHHCCS CS
      NB-ARC  23 valvGmgGvGKttlakqilnk 43 
                 + l+G +G+GKt la+ i  +
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGE 282
                 679************999765 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 5.2
                 C CS
      NB-ARC  42 n 42 
                 n
  EFC38311.1 373 N 373
                 3 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00064
                 EEEEESTTSSHHHHHHHHCCSH CS
      NB-ARC  23 valvGmgGvGKttlakqilnks 44 
                 v l+G +G+GKt lak i n+s
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDS 610
                 679***************9994 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.0     0.015       5.4      24      43 ..     261     280 ..     252     298 .. 0.85
   2 ?   -0.9   0.0       3.2   1.2e+03     103     142 ..     339     373 ..     317     388 .. 0.74
   3 !   11.2   0.0   0.00063      0.23      20      51 ..     584     612 ..     568     630 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.015
                      -EEEECSTTSSHHHHHHHHH CS
  Sigma54_activat  24 svlitGesGtGKellaraih 43 
                       +l++G  G+GK++la+ai 
       EFC38311.1 261 GILLHGPPGCGKTMLANAIA 280
                      69***************996 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 3.2
                      GGS-HHHHHHHHHHHHHSEEESBTSSSEEE--EEEEEEES CS
  Sigma54_activat 103 gelplelQekLlrvlqegevervGsskeikvdvriiaatn 142
                      +e++ ++ ++L+++l++ ++e+ G+++       ii atn
       EFC38311.1 339 KEMEKRIVAQLITCLDDLTLEKTGGKTV-----IIIGATN 373
                      4677777888999999999999988754.....4555555 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00063
                      TSSS-EEEECSTTSSHHHHHHHHHHHSTTTTS CS
  Sigma54_activat  20 ktdlsvlitGesGtGKellaraiheaskrkek 51 
                      + ++ vl+ G  G+GK+lla+ai + s    +
       EFC38311.1 584 TAPAGVLLYGPPGCGKTLLAKAISNDSG---A 612
                      45689*****************987665...4 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   2.4       1.4   5.3e+02      33     116 ..     106     148 ..      52     193 .. 0.50
   2 !    8.9   0.1    0.0034       1.2      11      44 ..     250     283 ..     248     369 .. 0.67
   3 !    9.6   0.0    0.0021      0.79      23      43 ..     589     609 ..     584     617 .. 0.83
   4 ?    0.3   0.0       1.5   5.6e+02     119     172 ..     640     703 ..     613     751 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 1.4
    ATPase_2  33 KtaLlkeiienledkdkyviyyialreesiskldefieeeeekkklekalgiavpkaeleeilk..eksklvfkaielllekikkk 116
                 K a lke+i+n +                                           ++++  l+   k +  + ++e+  +++k+k
  EFC38311.1 106 KVAKLKEVINNEK-------------------------------------------TSMNYQLQnvYKEQSTNISLENNENDLKRK 148
                 1122222222221...........................................111111112222222233444444444444 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0034
    ATPase_2  11 leeilerepneiyfiYGpegsGKtaLlkeiienl 44 
                 + + l  ep + +++ Gp g+GKt L + i+ +l
  EFC38311.1 250 IYSTLGVEPPRGILLHGPPGCGKTMLANAIAGEL 283
                 56667778888899**************999877 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.0021
    ATPase_2  23 yfiYGpegsGKtaLlkeiien 43 
                 +++YGp g+GKt L k i + 
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISND 609
                 579*********999887664 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 1.5
    ATPase_2 119 k......iiiiiDelqklidlgln......gaellvkeLlnliesltkekhlcvviclsSeglfie 172
                 +       +i++De+  l     +      ++e +v++Ll++++  ++++ +++vi+++    +i+
  EFC38311.1 640 RaaasspCVIFFDEMDALCPKR-DnesssqSSERVVNQLLTAMDG-LESRGMVFVIAATNRPDMID 703
                 3333455799999999987322.2466666899999999999999.66777888888887666666 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0086       3.2       5      22 ..     262     279 ..     259     346 .. 0.80
   2 !   10.4   0.0    0.0011      0.39       5      22 ..     589     606 ..     585     624 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0086
      AAA_24   5 iliyGpsgiGKTtlakel 22 
                 il+ Gp+g GKT+la+ +
  EFC38311.1 262 ILLHGPPGCGKTMLANAI 279
                 89*************987 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.0011
      AAA_24   5 iliyGpsgiGKTtlakel 22 
                 +l+yGp+g GKT lak +
  EFC38311.1 589 VLLYGPPGCGKTLLAKAI 606
                 89*************987 PP

>> Cytidylate_kin2  Cytidylate kinase-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.2       7.4   2.7e+03      38     155 ..      91     113 ..      75     145 .. 0.57
   2 !   14.1   0.0   0.00011      0.04       8      91 ..     268     355 ..     262     371 .. 0.69
   3 ?    3.3   0.0      0.22        81       8      66 ..     595     653 ..     591     693 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 7.4
  Cytidylate_kin2  38 kelglseeeveevdersrlssflskllaarvagdtldeklddelfeaqervirelaaeesvVivGRgadliLkdrpnvlrvfltapledrvkrv 131
                      +e ++s+ee+                                                                                    
       EFC38311.1  91 EEEQISKEEL------------------------------------------------------------------------------------ 100
                      4444444444.................................................................................... PP

  Cytidylate_kin2 132 aereglseeearekiketDkrrak 155
                                 ++++++  k ++ 
       EFC38311.1 101 -----------EKRMQKVAKLKEV 113
                      ...........3333333333322 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 0.00011
  Cytidylate_kin2   8 yGsgGetigeaLAekLglpfydreiieevakelglseeev.eevde...rsrlssflskllaarvagdtldeklddelfeaqervire 91 
                       G+g++ ++ a+A +L++pf+    +e v+  +g se+++ + + +   ++++  f++++ a   + d+ +++++++++    + + +
       EFC38311.1 268 PGCGKTMLANAIAGELQIPFLKVSAPEIVSGMSGESEAKIrQIFRDaisNAPSIIFIDEIDAILSKRDNASKEMEKRIVAQLITCLDD 355
                      7***************************************766666655444455555555554444444555555555444444444 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.22
  Cytidylate_kin2   8 yGsgGetigeaLAekLglpfydreiieevakelglseeeveevdersrlssflskllaa 66 
                       G+g++ +++a++++ g +f++ + +e + k  g se  v++v  r+++ss    ++++
       EFC38311.1 595 PGCGKTLLAKAISNDSGANFISIKGPELLNKYVGESERAVRQVFSRAAASSPCVIFFDE 653
                      59*********************999999999999999996666655544444333333 PP

>> AAA_3  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   0.0     0.002      0.74       2      31 ..     262     291 ..     261     349 .. 0.81
   2 !    8.1   0.0    0.0063       2.3       2      37 ..     589     623 ..     588     716 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.002
       AAA_3   2 vllegvPGlaktllvkalakaldlefkriq 31 
                 +ll+g PG +kt+l++a+a  l++ f ++ 
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQIPFLKVS 291
                 79********************99998875 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0063
       AAA_3   2 vllegvPGlaktllvkalakaldlefkriqftpdll 37 
                 vll g PG +ktll+ka+++  +++f  i+  p+ll
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGANFISIK-GPELL 623
                 7999****************9999998886.45555 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0    0.0028         1       1      71 [.     262     327 ..     262     330 .. 0.65
   2 !    8.2   0.0    0.0049       1.8       5      71 ..     593     654 ..     589     659 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0028
  Viral_helicase1   1 ivvhGvpGcGKStlirkllrts.liltvnrptaelltegkpklpnlsvrtvdsflmalvkstkgkililDEy 71 
                      i+ hG pGcGK+ l   ++ +    + +++   e+++  + +++++    ++++ +++       i+++DE+
       EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELqIPFLKVSA-PEIVSGMSGESEAKIRQIFRDAISNAP-----SIIFIDEI 327
                      578**********999999885433333333.555555556666666666666666653.....37777775 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0049
  Viral_helicase1   5 GvpGcGKStlirkllrts.liltvnrptaelltegkpklpnlsvrtvdsflmalvkstkgkililDEy 71 
                      G pGcGK+ l + + ++s  ++ +++   ell++ + ++  + vr v s   a ++ +   ++++DE 
       EFC38311.1 593 GPPGCGKTLLAKAISNDSgANFISIKG-PELLNKYVGES-ERAVRQVFSRAAASSP-C---VIFFDEM 654
                      78*************999988888888.89999998444.4446666655555444.3...8888886 PP

>> Parvo_NS1  Parvovirus non-structural protein NS1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0    0.0031       1.2     117     135 ..     262     280 ..     254     285 .. 0.90
   2 !    8.5   0.0    0.0026      0.94     117     136 ..     589     608 ..     587     612 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0031
   Parvo_NS1 117 vwfyGpantGktnlaeaIa 135
                 ++++Gp+ +Gkt+la+aIa
  EFC38311.1 262 ILLHGPPGCGKTMLANAIA 280
                 889***************9 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0026
   Parvo_NS1 117 vwfyGpantGktnlaeaIak 136
                 v++yGp+ +Gkt la+aI +
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISN 608
                 799***************86 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0091       3.3      34      58 ..     260     284 ..     249     334 .. 0.83
   2 !    8.2   0.0    0.0044       1.6      33      58 ..     586     611 ..     576     670 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0091
       AAA_7  34 kpvllvGptGtGKtviikdllkkld 58 
                 + +ll Gp G+GKt++++ +  +l+
  EFC38311.1 260 RGILLHGPPGCGKTMLANAIAGELQ 284
                 679*************999877765 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0044
       AAA_7  33 kkpvllvGptGtGKtviikdllkkld 58 
                    vll+Gp G+GKt+++k + +   
  EFC38311.1 586 PAGVLLYGPPGCGKTLLAKAISNDSG 611
                 5679*************999877655 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.2       7.4   2.7e+03     104     116 ..      97     109 ..      75     150 .. 0.54
   2 !    7.2   0.0    0.0078       2.9       6      37 ..     228     277 ..     225     285 .. 0.76
   3 ?   -0.1   0.1       1.3   4.7e+02     111     153 ..     311     355 ..     287     372 .. 0.69
   4 !    8.8   0.0    0.0025      0.93      10      37 ..     577     604 ..     570     610 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 7.4
      ATPase 104 leelieelaeaik 116
                  eel ++++++ k
  EFC38311.1  97 KEELEKRMQKVAK 109
                 3333333333322 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0078
      ATPase   6 eglDeilk..................gGipegrvvlitGepGtGKtifal 37 
                  g+D+il+                   G+   r +l+ G pG+GKt++a 
  EFC38311.1 228 GGIDNILQdirelieypilhpeiystLGVEPPRGILLHGPPGCGKTMLAN 277
                 5666666556666666666666666678888899*************986 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 1.3
      ATPase 111 laeaikeikakrvviDsitgl.aye..ekeavaReilrqlvrvlkk 153
                 +++ai++   + + iD i+++ +++  +++++ ++i+ ql++ l +
  EFC38311.1 311 FRDAISNA-PSIIFIDEIDAIlSKRdnASKEMEKRIVAQLITCLDD 355
                 44444433.3678899999996443114456778888888888765 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.0025
      ATPase  10 eilkgGipegrvvlitGepGtGKtifal 37 
                 +  k G+   + vl++G pG+GKt++a+
  EFC38311.1 577 HYKKLGLTAPAGVLLYGPPGCGKTLLAK 604
                 555668888899**************96 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0  12.9   4.8e-06    0.0018     258     375 ..      90     200 ..      22     256 .. 0.52
   2 ?   -2.7   2.4       4.4   1.6e+03     303     358 ..     809     869 ..     715     883 .] 0.47

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 4.8e-06
    Macoilin 258 kkksakssrsdskkkhehn....esvdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskkasagsagssnssskkhses 352
                 +++++ s+ ++ +k+ ++     e +++++++++y+ +++ ++++++ + +++e++l+++ +  ++ss++++++ +ns+          +sss++ s+s
  EFC38311.1  90 SEEEQISK-EELEKRMQKVaklkEVINNEKTSMNYQLQNVYKEQSTNISLENNENDLKRKREQPNSSSTTTNTTPSNSQ----------SSSSNNTSAS 177
                 11111111.1111111111233344455555555555555555555555555555555555544444444443333333..........2222222222 PP

    Macoilin 353 sksvtsssssknskkqklpaGks 375
                 s+s t ssss++++ +++p  k+
  EFC38311.1 178 SNSNTASSSSSSKEVKEAPPQKK 200
                 22222222222111111111111 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 4.4
    Macoilin 303 ssgsesellveesvkskssssssssn...knskkasagsagssnsssk..khsessksvts 358
                  s s+++l+  e++ s+  +s ++ n   +n+   +++  +s +s+++  +++  ++s ++
  EFC38311.1 809 PSVSSKDLKIYEKIASSLRTSRNHINmdePNTPIPQSDVEKSESSAPQtkHLKVDTNSGKK 869
                 3344444444444444433333333312111111111111111111110011111111111 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.076        28      52      84 ..     258     290 ..     234     431 .. 0.83
   2 !    8.5   0.0    0.0028         1      54     114 ..     587     652 ..     530     710 .. 0.64

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.076
      DUF815  52 pannvLLwGarGtGKSslvkallneyaeegLrl 84 
                 p + +LL G  G+GK  l  a+  e++   L++
  EFC38311.1 258 PPRGILLHGPPGCGKTMLANAIAGELQIPFLKV 290
                 556799***********9999999998777765 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0028
      DUF815  54 nnvLLwGarGtGKSslvkallneyaeeg..Lrlievekedlkelpklvellr...erperfilfvD 114
                   vLL+G  G+GK  l ka+ n+  ++   ++  e+ ++ + e ++ v+++    +++  +++f D
  EFC38311.1 587 AGVLLYGPPGCGKTLLAKAISNDSGANFisIKGPELLNKYVGESERAVRQVFsraAASSPCVIFFD 652
                 579*****************9998877633333466666666666666655422233345666665 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0     0.014       5.1       4      24 ..     262     282 ..     260     299 .. 0.80
   2 ?    6.4   0.0      0.02       7.2       4      24 ..     589     609 ..     587     614 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.014
   PduV-EutP   4 illiGkvgsGKttLtqalkge 24 
                 ill G+ g+GKt L++a+ ge
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGE 282
                 8999**************985 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.02
   PduV-EutP   4 illiGkvgsGKttLtqalkge 24 
                 +ll G+ g+GKt L++a++++
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISND 609
                 899***************985 PP

>> Bac_DnaA  Bacterial dnaA  protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0     0.014       5.2      37     180 ..     262     414 ..     257     451 .. 0.61
   2 ?    6.5   0.0     0.018       6.5      37      62 ..     589     614 ..     583     749 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.014
                 EEEE-SSSSSHHHHHHHHHHHHHHHSSSS-EEEEEHHHHHHHHHHHHHTT-HHHHHHHHTT-.SEEEEE-GGGGTT-......H...HHHHHHHHHHHH CS
    Bac_DnaA  37 lfiygevGlGktHLlkaignevlenapelrvvYltaeeFlnelvkalrdkkaeefkeklrkv.DvLliDDiqflagk......e...ktqeelfhtfna 125
                 ++++g+ G Gkt L +ai+ e++   p l+   ++a e ++ +    + k  + f++ + ++  ++ iD+i  + +k      e   ++  +l++ ++ 
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQI--PFLK---VSAPEIVSGMSGESEAKIRQIFRDAISNApSIIFIDEIDAILSKrdnaskEmekRIVAQLITCLDD 355
                 799***************988754..3344...467788888777777777777888887552577788888775551111112111222334555555 PP

                 HHTT...T-E.EEEEESS-TTT-SS--HHHHHHHHSSEEEE-----HHHHH.HHHHHHHH CS
    Bac_DnaA 126 llee...gkq.vvlssDrsPkeleeledrlrsrfeaGlvvdieppdletrl.ailkkkie 180
                 l+ e   gk  +++ +   P +l++   r   rf++ ++  i +    +++ +il +k++
  EFC38311.1 356 LTLEktgGKTvIIIGATNRPDSLDDALRR-AGRFDREISLGIPDEKARMKIlNILTRKLK 414
                 43221112331456677777666554333.457777666666444444432245556555 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.018
                 EEEE-SSSSSHHHHHHHHHHHHHHHS CS
    Bac_DnaA  37 lfiygevGlGktHLlkaignevlena 62 
                 +++yg+ G Gkt L kai+n   +n+
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGANF 614
                 79****************99876655 PP

>> Sigma54_activ_2  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0      0.19        68      24      42 ..     262     280 ..     257     335 .. 0.88
   2 !   10.1   0.0    0.0018      0.67      22      47 ..     587     612 ..     579     659 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.19
                      EEEEEETT--HHHHHHCC- CS
  Sigma54_activ_2  24 vfltGekGsgkelvArlLh 42 
                      ++l G++G+gk++ A++++
       EFC38311.1 262 ILLHGPPGCGKTMLANAIA 280
                      799************9986 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.0018
                      S-EEEEEETT--HHHHHHCC--TTS- CS
  Sigma54_activ_2  22 lpvfltGekGsgkelvArlLhknsgp 47 
                      + v+l G++G+gk+l A+++++ sg 
       EFC38311.1 587 AGVLLYGPPGCGKTLLAKAISNDSGA 612
                      679******************99886 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0     0.031        11       2      24 ..     262     284 ..     261     299 .. 0.88
   2 ?   -0.3   0.1       2.4   8.8e+02      85     106 ..     307     329 ..     298     348 .. 0.70
   3 ?    0.9   0.0       1.1   3.9e+02      71     123 ..     517     573 ..     501     578 .. 0.69
   4 ?    3.5   0.0      0.17        61       2      22 ..     589     609 ..     588     624 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.031
                 EEEE--TTSSHHHHHHHHHHHH. CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlellk 24 
                 +++ GppG GKt l + ++ +l+
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQ 284
                 6899**************99986 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 2.4
                 HHHHHHHHH.HHH-EEEE---ST CS
    NTPase_1  85 alealrkal.seadviviDEiGk 106
                 + +++r a+ + + +i iDEi  
  EFC38311.1 307 IRQIFRDAIsNAPSIIFIDEIDA 329
                 45566666645567******965 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 1.1
                 ETTEEE-HHHHHHHHHHHHHHHHHHH-.....EEEE---STTGGG-HHHHHHHHHHHT CS
    NTPase_1  71 vgkyvvdvesfeelalealrkalsead.....viviDEiGkmElkskkfkeaveevLk 123
                 + + +v+ ++fe+  +++++ + ++++      +  D iG +E   ++++ a+ e +k
  EFC38311.1 517 LANLYVTFNDFEKA-IKKVQPSAKREGfatvpNVTWDDIGALEEVREELRMAIMEPIK 573
                 55667777777774.5555555555554443345669999999999999999877665 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.17
                 EEEE--TTSSHHHHHHHHHHH CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlel 22 
                 v++ GppG GKt l k +++ 
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISND 609
                 6788********999988775 PP

>> CPT  Chloramphenicol phosphotransferase-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0    0.0015      0.57       4      43 ..     262     301 ..     260     350 .. 0.88
   2 ?    3.3   0.0      0.17        63       4      37 ..     589     622 ..     587     705 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.0015
                 EEEEE-TTSSHHHHHHHHHHHSSS-EEEEEHHHHHHHS-G CS
         CPT   4 ilLnGgsssGKsslaralqevldepwlhlgvDafvealpp 43 
                 ilL+G +  GK+ la+a+   l+ p+l++   + v  +  
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQIPFLKVSAPEIVSGMSG 301
                 9***************************998777776655 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.17
                 EEEEE-TTSSHHHHHHHHHHHSSS-EEEEEHHHH CS
         CPT   4 ilLnGgsssGKsslaralqevldepwlhlgvDaf 37 
                 +lL G +  GK+ la+a+ + + + ++ ++  ++
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGANFISIKGPEL 622
                 89****************9999999988865555 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   1.3       6.1   2.2e+03      39      81 ..      88     130 ..      79     150 .. 0.70
   2 ?   11.5   0.0    0.0008      0.29       2      26 ..     266     290 ..     265     320 .. 0.88
   3 ?    9.7   0.1     0.003       1.1       1      26 [.     592     617 ..     592     749 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 6.1
                 SHSSHHHHCTSHHHHHHHHHHHHHHHHHHHHHSSEEEEEE-SE CS
      AAA_17  39 lakardemrklpleekkelqkeaaekiaeeakkkgvlvdghpr 81 
                 +++++++++k++le++ +  ++++e i++e+ ++++ +   + 
  EFC38311.1  88 SSSEEEQISKEELEKRMQKVAKLKEVINNEKTSMNYQLQNVYK 130
                 4567788888888888777788888888888888777666654 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.0008
                 E-TTSSHHHHHHHHHHHHTEEEEEH CS
      AAA_17   2 GgPGsGKgtqceklvekygfthlsa 26 
                 G+PG+GK+ +++ ++ ++++++l  
  EFC38311.1 266 GPPGCGKTMLANAIAGELQIPFLKV 290
                 9*******************99864 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.003
                 EE-TTSSHHHHHHHHHHHHTEEEEEH CS
      AAA_17   1 lGgPGsGKgtqceklvekygfthlsa 26 
                 +G+PG+GK+ +++ +  + g  ++s 
  EFC38311.1 592 YGPPGCGKTLLAKAISNDSGANFISI 617
                 7***************9998888775 PP

>> AFG1_ATPase  AFG1-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.0    0.0017      0.63      59      82 ..     256     279 ..     251     369 .. 0.72
   2 ?    1.6   0.0      0.27        99      58      79 ..     582     603 ..     553     608 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0017
  AFG1_ATPase  59 vepvrglYlwGgvGrGKtylmdlf 82 
                  vep+rg+ l+G+ G GKt+l +  
   EFC38311.1 256 VEPPRGILLHGPPGCGKTMLANAI 279
                  589*****************8765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.27
  AFG1_ATPase  58 svepvrglYlwGgvGrGKtylm 79 
                    +++ g+ l+G+ G GKt l 
   EFC38311.1 582 GLTAPAGVLLYGPPGCGKTLLA 603
                  457999*************985 PP

>> Nucleolin_bd  Nucleolin binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00074      0.27       5      55 ..      19      72 ..      15      87 .. 0.74
   2 ?   -0.1   0.5       2.1   7.6e+02       6      44 ..      94     131 ..      90     133 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00074
  Nucleolin_bd  5 gsfsDkrLvqRveqyLesnedseyvDvda..maaeLqrqYr.eYgRrkrnaFri 55
                  + +  + L++R+e+y+es+++  +   +   ++++L++  + +Y+  +  +F+ 
    EFC38311.1 19 PKIDESALLERIEEYMESHDKTSIGEKEIlpLCTYLRKSHEkDYKQIPLLDFKE 72
                  5667789*********777776665544422699******99**9877777765 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 2.1
  Nucleolin_bd   6 sfsDkrLvqRveqyLesnedseyvDvdamaaeLqrqYre 44 
                   ++s + L +R +++  + ++        m  +Lq+ Y+e
    EFC38311.1  94 QISKEELEKRMQKVA-KLKEVINNEKTSMNYQLQNVYKE 131
                   566778888888883.5555444555679999***9997 PP

>> PhoH  PhoH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0     0.027        10      24      40 ..     264     280 ..     259     285 .. 0.86
   2 ?    5.5   0.1     0.028        10      22      39 ..     589     606 ..     579     613 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.027
                 EE--TTSSTTHHHHHHH CS
        PhoH  24 aiGpaGtGKtylavala 40 
                   Gp G+GKt+la a+a
  EFC38311.1 264 LHGPPGCGKTMLANAIA 280
                 67***********9988 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.028
                 EEEE--TTSSTTHHHHHH CS
        PhoH  22 vfaiGpaGtGKtylaval 39 
                 v   Gp G+GKt+la a+
  EFC38311.1 589 VLLYGPPGCGKTLLAKAI 606
                 6789***********876 PP

>> SKI  Shikimate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.8       8.7   3.2e+03     119     145 ..     116     143 ..      79     178 .. 0.62
   2 ?    6.4   0.0     0.025       9.1       1      22 [.     268     289 ..     268     315 .. 0.82
   3 ?    4.7   0.0     0.083        30       1      22 [.     595     616 ..     595     640 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 8.7
                 HHHHHHH.HHHHHHCCSSCEEEECTSSH CS
         SKI 119 elleela.ereplyeeaadvvvdesees 145
                 ++++++  + +++y+e ++ ++ e++e+
  EFC38311.1 116 NEKTSMNyQLQNVYKEQSTNISLENNEN 143
                 2222233344455655555555555554 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.025
                 TTSSHHHHHHHHHHHHTSEEEE CS
         SKI   1 mGaGKstvGkllAkklglefiD 22 
                 +G+GK+ +++++A +l+++f+ 
  EFC38311.1 268 PGCGKTMLANAIAGELQIPFLK 289
                 6******************985 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.083
                 TTSSHHHHHHHHHHHHTSEEEE CS
         SKI   1 mGaGKstvGkllAkklglefiD 22 
                 +G+GK+ ++k++++  g +fi 
  EFC38311.1 595 PGCGKTLLAKAISNDSGANFIS 616
                 6****************99985 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       9.4   3.4e+03      31      58 ..     208     231 ..     178     243 .. 0.67
   2 ?    6.0   0.0     0.032        12       2      22 ..     262     282 ..     261     360 .. 0.74
   3 ?    2.8   0.0      0.33   1.2e+02       2      22 ..     589     609 ..     588     621 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 9.4
                 TSSSSEEEEEEEETTEEEEEEECGGCSS CS
    MMR_HSR1  31 gtTrdinegrvklkgkeielvDtpGlie 58 
                 g  ++++ + v+   ++i++ D+ G i+
  EFC38311.1 208 GSSKKPKII-VE--TPNIRFSDIGG-ID 231
                 444444444.33..57899999999.54 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.032
                 EEEEESTTSSHHHHHHHHHTS CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltge 22 
                 +++ G p  GK+ L na+ ge
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGE 282
                 6789***************95 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.33
                 EEEEESTTSSHHHHHHHHHTS CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltge 22 
                 v+++G p  GK+ L +a++++
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISND 609
                 7899**************986 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.1     0.049        18      12      33 ..     261     282 ..     256     348 .. 0.90
   2 ?    4.5   0.1      0.11        40      13      30 ..     589     606 ..     583     613 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.049
      AAA_19  12 vllvtaGpGtGKTrvlkhival 33 
                  +l+ ++pG+GKT + ++i  +
  EFC38311.1 261 GILLHGPPGCGKTMLANAIAGE 282
                 57999********988877655 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.11
      AAA_19  13 llvtaGpGtGKTrvlkhi 30 
                 +l+ ++pG+GKT + k+i
  EFC38311.1 589 VLLYGPPGCGKTLLAKAI 606
                 7899********887665 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.5       6.1   2.2e+03      62      99 ..      88     127 ..      85     151 .. 0.56
   2 ?    7.1   0.0      0.01       3.7       3      23 ..     262     282 ..     260     285 .. 0.89
   3 ?    2.2   0.0      0.32   1.2e+02       3      22 ..     589     608 ..     587     614 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 6.1
                 SSSHHHHHHHHHHHCTSSSE..EEEEEEGGGHHHHHHHHH CS
      FeoB_N  62 ayseeekvardflleeepdv..vvnvvdatnlernLyLtl 99 
                 + seee+++++ l ++ ++v  + +v++ ++   n +L  
  EFC38311.1  88 SSSEEEQISKEELEKRMQKVakLKEVINNEKTSMNYQLQN 127
                 5789999999998754333211344555555554544444 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.01
                 EEEEESTTSSHHHHHHHHHTT CS
      FeoB_N   3 valvGnpnvGkttlfnaltga 23 
                 + l G p +Gkt+l na++g 
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGE 282
                 6799**************996 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.32
                 EEEEESTTSSHHHHHHHHHT CS
      FeoB_N   3 valvGnpnvGkttlfnaltg 22 
                 v l G p +Gkt l  a+++
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISN 608
                 7899**********999876 PP

>> Menin  Menin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9  14.1     0.019         7     506     621 ..     104     223 ..      77     235 .. 0.40

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.019
       Menin 506 gekilnpdfllqggdqplaeqkqkkageeserre.annnnnsksnsekeadkkasttsnggeass.......tpsseseaavespsehkeakleeksqe 596
                  +k+ +   +++  + ++  q q+   e+s++   +nn+n+ k + e+   +++stt+n++ ++s       t+ s+ +++ +s s+ ke k     q+
  EFC38311.1 104 MQKVAKLKEVINNEKTSMNYQLQNVYKEQSTNISlENNENDLKRKREQ--PNSSSTTTNTTPSNSqssssnnTSASSNSNTASSSSSSKEVKEAPP-QK 199
                 233434444444444444444444445555554433444444443333..2222233332222220000121222222223333334455544333.34 PP

       Menin 597 lasappaavddydefeimlkrPvit 621
                 ++++ p++    ++ +i+++ P i 
  EFC38311.1 200 KTKSDPSSGSS-KKPKIIVETPNIR 223
                 45555553333.4456666666655 PP

>> Hydin_ADK  Hydin Adenylate kinase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1  12.1      0.14        51      27     159 ..      75     187 ..      62     215 .. 0.40
   2 ?    7.1   0.0     0.017       6.1       2      31 ..     262     291 ..     261     317 .. 0.85
   3 ?    1.4   0.0      0.92   3.4e+02       2      30 ..     589     617 ..     588     619 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.14
   Hydin_ADK  27 lltiDsvvleAisdgnssaGlrArelCaeaaieqaekekeeaaeeaekkegqlsvealvkktselssaaeekaas........skiskkkktsvvsgkk 117
                 l++iD ++ e  s+++ +  +   el                                 k+++++++ +e  +++        + + k++ t++  +++
  EFC38311.1  75 LVAIDRLLGEDESSSSEEEQISKEEL--------------------------------EKRMQKVAKLKEVINNEktsmnyqlQNVYKEQSTNISLENN 141
                 33444444444444444444444444................................44443333332222222222233333333334444444444 PP

   Hydin_ADK 118 kaesegaksqkqkekktseta....qissspplaapiarrLsvsas 159
                 +++ + + +q +++++t++t+    q+sss  ++a  +   + s+s
  EFC38311.1 142 ENDLKRKREQPNSSSTTTNTTpsnsQSSSSNNTSASSNSNTASSSS 187
                 4444444444333333333332322222222222222222222222 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.017
   Hydin_ADK   2 iivhGaPlsGKtatavtLakkYeaAlltiD 31 
                 i++hG+P  GKt  a ++a + ++ +l + 
  EFC38311.1 262 ILLHGPPGCGKTMLANAIAGELQIPFLKVS 291
                 889****************99998888775 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.92
   Hydin_ADK   2 iivhGaPlsGKtatavtLakkYeaAllti 30 
                 +++ G+P  GKt  a +++   +a +++i
  EFC38311.1 589 VLLYGPPGCGKTLLAKAISNDSGANFISI 617
                 5789****************999999988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (883 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2369  (0.132132); expected 358.6 (0.02)
Passed bias filter:                      663  (0.0369792); expected 358.6 (0.02)
Passed Vit filter:                       158  (0.00881254); expected 17.9 (0.001)
Passed Fwd filter:                        61  (0.00340231); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              49  [number of targets reported over threshold]
# CPU time: 1.20u 0.33s 00:00:01.53 Elapsed: 00:00:00.53
# Mc/sec: 4985.73
//
Query:       EFC38312.1  [L=285]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-13   50.9   0.2    3.4e-13   49.6   0.1    1.7  2  JAB         JAB1/Mov34/MPN/PAD-1 ubiquitin protease
    0.00061   20.2   4.6    0.00061   20.2   4.6    1.7  2  MitMem_reg  Maintenance of mitochondrial structure and functi
  ------ inclusion threshold ------
       0.45   10.7   4.8       0.14   12.4   1.4    1.9  2  Cnn_1N      Centrosomin N-terminal motif 1
        1.3    9.5   4.7       0.51   10.8   1.4    2.0  2  UPF0449     Uncharacterised protein family UPF0449


Domain annotation for each model (and alignments):
>> JAB  JAB1/Mov34/MPN/PAD-1 ubiquitin protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.6   0.1   7.5e-17   3.4e-13       3      96 ..      19     108 ..      17     124 .. 0.87
   2 ?   -2.3   0.0      0.95   4.3e+03      29      39 ..     164     174 ..     150     219 .. 0.58

  Alignments for each domain:
  == domain 1  score: 49.6 bits;  conditional E-value: 7.5e-17
                 SCEEEEEHHHHHHHHHHHHHHHHHT.S--EEEEEEEESSSEEEEEEEEEEESEEEESSECEEEEEHHHHHHHHHHHHHHHCTTSEEEEEEEESSS CS
         JAB   3 vqavhleslvllkildhalrtekee.eevmGlliGelnddttveitnvfalpfeetekdvdavsldqeylekksellkklrgrervvGWYhshpd 96 
                   +++l++lv+l+ildh++r++ ++   ++G+l Ge+++   +ei n + l+f e+++d     +d +y++k+++l+ ++  +  ++G+Y+    
  EFC38312.1  19 TSTYKLHPLVMLNILDHYQRVAFNSkTDIIGCLFGEFREGGYFEIKNTIPLKFTENTTD-----IDVSYYKKMESLHHRVYSNDTLIGFYTISTS 108
                 5689****************99776589******************************9.....888999**********999*******74333 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.95
                 --EEEEEEEES CS
         JAB  29 evmGlliGeln 39 
                 +v+G+l  +++
  EFC38312.1 164 KVVGTLFEQVR 174
                 55555543333 PP

>> MitMem_reg  Maintenance of mitochondrial structure and function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.5   6.6e+03      52      57 ..     107     112 ..      73     132 .. 0.57
   2 !   20.2   4.6   1.4e-07   0.00061      29     110 ..     202     277 ..     171     279 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.5
  MitMem_reg  52 egelpv 57 
                 + +++v
  EFC38312.1 107 TSKTTV 112
                 223333 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 1.4e-07
  MitMem_reg  29 qyyslkilqerldlikdYlkkveegelpvnheilrnlqkllnllPhleteelekefnvetnDvllvvyLasltrsilalnel 110
                  ++ +++l++ l++i +Yl++  ++    n e+   l + ++ll  +++  ++k + ++ +D+ ++vyL+ l++  l++ne 
  EFC38312.1 202 LQQTIQQLKKDLEEIGKYLQSSNKK----NFELYHFLLSSFQLLKPVDD--FDKTIGQHNKDLQMIVYLSHLLQQNLKINEQ 277
                 5678999*************99933....67999999999999999988..************************9999985 PP

>> Cnn_1N  Centrosomin N-terminal motif 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.4   3.1e-05      0.14      37      72 ..     191     226 ..     173     227 .. 0.85
   2 ?   -1.9   0.1      0.88   3.9e+03      41      54 ..     267     280 ..     248     285 .] 0.60

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.1e-05
      Cnn_1N  37 qkeellkenielkveveslqkelkekkkllreaeka 72 
                 q ++ l++ni l++++++l+k+l+e  k l++++k+
  EFC38312.1 191 QTNKYLQSNIVLQQTIQQLKKDLEEIGKYLQSSNKK 226
                 67788999***********************99986 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.88
      Cnn_1N  41 llkenielkveves 54 
                 ll++n ++ +++ +
  EFC38312.1 267 LLQQNLKINEQLTT 280
                 44445554444444 PP

>> UPF0449  Uncharacterised protein family UPF0449
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   1.4   0.00011      0.51      54      89 ..     182     217 ..     158     226 .. 0.81
   2 ?   -1.3   0.1      0.67     3e+03      65      80 ..     269     284 ..     239     285 .] 0.64

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00011
     UPF0449  54 eaeveelYeqvrtylelnerLeeakeeLkqkceeLk 89 
                 +++ +  Y q+++yl+ n  L+++ ++Lk+ +ee+ 
  EFC38312.1 182 NEKLSMNYLQTNKYLQSNIVLQQTIQQLKKDLEEIG 217
                 4557788**********************9977764 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.67
     UPF0449  65 rtylelnerLeeakee 80 
                 +++l++ne+L  +++e
  EFC38312.1 269 QQNLKINEQLTTTSHE 284
                 5566677777666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1277  (0.0712254); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.44
# Mc/sec: 1937.31
//
Query:       EFC38313.1  [L=193]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00014   21.4   9.0     0.0028   17.2   0.2    2.8  3  GATA            GATA zinc finger
  ------ inclusion threshold ------
      0.099   12.6   6.0       0.03   14.3   3.6    1.4  2  Tir_receptor_C  Translocated intimin receptor (Tir) C-terminu
       0.15   10.0   4.8       0.17    9.8   4.8    1.1  1  Dicty_REP       Dictyostelium (Slime Mold) REP protein
       0.51    9.1   5.2       0.64    8.8   5.2    1.1  1  SWIRM-assoc_2   SWIRM-associated domain at the N-terminal
        2.4    8.3   5.5       0.62   10.2   1.7    2.1  2  Integrin_alpha  Integrin alpha cytoplasmic region


Domain annotation for each model (and alignments):
>> GATA  GATA zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   3.8   8.2e-06     0.029       1      14 [.      18      31 ..      18      42 .. 0.93
   2 !   17.2   0.2   7.8e-07    0.0028      16      34 ..      47      64 ..      45      66 .. 0.82
   3 ?   -5.2   2.1         5   1.8e+04       7       9 ..      97      99 ..      94     110 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 8.2e-06
        GATA  1 CsnCgttkTplWRr 14
                C nC+tt++plWR+
  EFC38313.1 18 CWNCKTTQSPLWRK 31
                99***********7 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 7.8e-07
        GATA 16 pdgnksLCnaCGlyykkkg 34
                p+ ++ LCn CGl++k ++
  EFC38313.1 47 PSTTY-LCNKCGLFFKRNK 64
                66677.**********986 PP

  == domain 3  score: -5.2 bits;  conditional E-value: 5
        GATA  7 tkT 9 
                t+T
  EFC38313.1 97 TTT 99
                333 PP

>> Tir_receptor_C  Translocated intimin receptor (Tir) C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       2.3   8.4e+03      50      76 ..      28      54 ..      25      57 .. 0.68
   2 ?   14.3   3.6   8.4e-06      0.03      58     128 ..      92     162 ..      77     190 .. 0.72

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 2.3
  Tir_receptor_C 50 lhrrnqPveqttttttttvttsttven 76
                    l r+  P+ +t  + t ++ ++t + n
      EFC38313.1 28 LWRKFSPTVETPEACTPSTPSTTYLCN 54
                    678888887777777777766665555 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 8.4e-06
  Tir_receptor_C  58 eqttttttttvttsttvenktan.ntsaqGnadtsgaee.tassrrdsqasvasslsdtsstdtvenPyaevk 128
                      qttttttttv+t+ + ++ t++  ts      ++++ee  + +r   +asv+s  +  s    v+ P +  +
      EFC38313.1  92 SQTTTTTTTTVATQPKRKQSTCElPTSLPSPLPSPKVEEkKKRKRTTTNASVSSLPATLS--ALVDKPSSHNN 162
                     588888999998888877777763577777999999999555666777889888554444..67777765544 PP

>> Dicty_REP  Dictyostelium (Slime Mold) REP protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   4.8   4.8e-05      0.17     248     303 ..      85     143 ..      58     184 .. 0.51

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 4.8e-05
   Dicty_REP 248 qpskeknkttttttttttttsqartrkrkaidddklsenqakekkknskksdddp....q 303
                 +  k+k+++t ttttttt+ +q++++++    + +l +++   k +++kk +  +     
  EFC38313.1  85 SSPKKKKSQT-TTTTTTTVATQPKRKQSTCELPTSLPSPLPSPKVEEKKKRKRTTtnasV 143
                 3333333333.3344445555555555555555555443332222222222222222232 PP

>> SWIRM-assoc_2  SWIRM-associated domain at the N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   5.2   0.00018      0.64     295     377 ..      79     160 ..      59     177 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00018
  SWIRM-assoc_2 295 rsPsPpskkeskkksgrkgaasarrkkkkeeeeeeedltkdmedptpepnieevelpksvnskkdselqpvkggtltDldeqe 377
                     sPs  s++ +kkks+ +++++++   + ++++ + +l   +  p p p++ee +  k ++++    + p + ++l+D   + 
     EFC38313.1  79 SSPSIISSP-KKKKSQTTTTTTTTVATQPKRKQSTCELPTSLPSPLPSPKVEEKKKRKRTTTNASVSSLPATLSALVDKPSSH 160
                    577777777.6777766666555555666778888899999999*******99999999988888888888888888865533 PP

>> Integrin_alpha  Integrin alpha cytoplasmic region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   1.7   0.00017      0.62       1      11 [.      55      66 ..      55      70 .. 0.83
   2 ?   -2.5   0.1         2   7.1e+03       6       9 ..     133     136 ..     133     139 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00017
                    HCC.CHHHCHHH CS
  Integrin_alpha  1 KcG.FFKRnykp 11
                    KcG FFKRn+k+
      EFC38313.1 55 KCGlFFKRNKKQ 66
                    7777******97 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2
                     HHCH CS
  Integrin_alpha   6 KRny 9  
                     KR++
      EFC38313.1 133 KRKR 136
                     8998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (193 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1340  (0.0747392); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.29s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1306.13
//
Query:       EFC38314.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.6    9.0   3.6        0.9    9.8   0.2    2.0  2  VirB3     Type IV secretory pathway, VirB3-like protein


Domain annotation for each model (and alignments):
>> VirB3  Type IV secretory pathway, VirB3-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.4      0.09   1.6e+03      22      47 ..      77     102 ..      73     123 .. 0.59
   2 ?    9.8   0.2     5e-05       0.9      37      67 ..     251     279 ..     241     291 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.09
       VirB3  22 lvllnllvsvilflvglslwillllv 47 
                 l+ll +++ +i f+v +s+ i    v
  EFC38314.1  77 LLLLGMIINIISFIVIGSMTIYSYTV 102
                 44444455555555666666654444 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 5e-05
       VirB3  37 glslwillllvplhlvlrliakrDpqmfrvl 67 
                 g  + +l+++++++l+++l++k+D  m r l
  EFC38314.1 251 G--VCLLIAIPIVVLTFTLMIKKDISMSRKL 279
                 3..44555699***************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1878  (0.104747); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.46
# Mc/sec: 3154.75
//
Query:       EFC38315.1  [L=1279]
Description: hypothetical protein NAEGRDRAFT_73995 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   15.4   0.2         44    5.1   0.0    4.8  4  Ank_3     Ankyrin repeat
      0.065   13.5   0.0       0.25   11.6   0.0    2.0  1  DUF2838   Protein of unknown function (DUF2838)
       0.24   11.6   1.6         20    5.5   0.0    3.3  3  RRM_2     RNA recognition motif 2


Domain annotation for each model (and alignments):
>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.2   7.3e+03      10      29 ..     489     511 ..     480     512 .. 0.70
   2 ?    4.1   0.1     0.016        94       2      31 .]     596     626 ..     595     626 .. 0.76
   3 ?    5.1   0.0    0.0073        44       2      23 ..    1144    1170 ..    1143    1177 .. 0.82
   4 ?   -3.6   0.0         3   1.8e+04       4      18 ..    1190    1204 ..    1189    1210 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.2
       Ank_3  10 arsgnl...e.ivkfLlenkgadv 29 
                 a+++ +   e i+  L++  g+dv
  EFC38315.1 489 ASNNEYtidEnIISSLIK-AGCDV 511
                 556666332146999999.89997 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.016
       Ank_3   2 GetpLhlAarsgnle..ivkfLlenkgadvna 31 
                 ++++Lh  +  ++ +  iv  L++  g+d na
  EFC38315.1 596 NQNLLHKLINLCSKArgIVSKLIQ-LGVDANA 626
                 578889666666665456******.****996 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0073
       Ank_3    2 GetpLhlAarsgnl....e.ivkfLle 23  
                  G t++h+A+   n+    + ivk L++
  EFC38315.1 1144 GKTLIHFACQKPNYypdkDvIVKDLIN 1170
                  89************9976467988887 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 3
       Ank_3    4 tpLhlAarsgnleiv 18  
                  t+ ++A++s +++ +
  EFC38315.1 1190 TAAFYALESRSCDFI 1204
                  788899999998733 PP

>> DUF2838  Protein of unknown function (DUF2838)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   4.2e-05      0.25      47      74 ..    1085    1112 ..    1074    1128 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.2e-05
     DUF2838   47 kkklhyfllDfCYfvnilllllllvlpe 74  
                  +k+ h+ llD+CY+  +++ll+ +vl++
  EFC38315.1 1085 HKHHHFSLLDICYWKGLMYLLFYIVLED 1112
                  5778899*********999999988744 PP

>> RRM_2  RNA recognition motif 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1      0.35   2.1e+03      14      57 ..     566     611 ..     555     625 .. 0.75
   2 ?    5.5   0.0    0.0033        20       6      36 ..     815     845 ..     811     860 .. 0.92
   3 ?    2.9   0.1     0.022   1.3e+02      27      70 ..    1198    1241 ..    1179    1248 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.35
       RRM_2  14 tkkmllaaide..knkgtydflylpidfknkcnvgyafinlvepkk 57 
                  ++ ll++id   k+  +y + + ++ f    n+ + +inl +  +
  EFC38315.1 566 ENNELLTTIDAfgKAYSKYGLSINELKFEKNQNLLHKLINLCSKAR 611
                 55678888887224456788888899999999********998654 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0033
       RRM_2   6 iknipnkytkkmllaaideknkgtydflylp 36 
                 i +ipnk t  +  + i  k++   df yl+
  EFC38315.1 815 IIDIPNKKTDALYYSVISSKSSEALDFSYLK 845
                 568**************************97 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.022
       RRM_2   27 kgtydflylpidfknkcnvgyafinlvepkkivafqkafngkkw 70  
                  + + df++  id+  k n g +  +l++ ++ + + k f+ k+ 
  EFC38315.1 1198 SRSCDFIFEVIDLSLKNNKGETVQDLMSDDNKIQYAKFFEKKET 1241
                  55689******************************999987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1466  (0.081767); expected 358.6 (0.02)
Passed bias filter:                      545  (0.0303977); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.92u 0.30s 00:00:01.22 Elapsed: 00:00:00.51
# Mc/sec: 7564.04
//
Query:       EFC38316.1  [L=176]
Description: acetyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-15   57.2   0.0    2.2e-15   56.9   0.0    1.2  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    3.9e-12   46.4   0.1    5.4e-12   46.0   0.1    1.3  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
      1e-11   44.9   0.0    1.7e-11   44.2   0.0    1.3  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    1.1e-06   29.4   0.0    1.3e-06   29.1   0.0    1.1  1  Acetyltransf_3   Acetyltransferase (GNAT) domain
      7e-06   26.3   0.2      4e-05   23.8   0.2    2.1  1  Acetyltransf_4   Acetyltransferase (GNAT) domain
    3.7e-05   23.8   0.0    7.8e-05   22.7   0.0    1.5  1  Acetyltransf_CG  GCN5-related N-acetyl-transferase
    6.1e-05   22.6   1.7    0.00018   21.0   1.7    1.9  1  Acetyltransf_15  Putative acetyl-transferase
     0.0003   20.7   0.0    0.00058   19.8   0.0    1.5  1  FR47             FR47-like protein
    0.00049   19.8   0.0    0.00085   19.1   0.0    1.4  1  PanZ             Acetyltransferase (GNAT) domain, PanZ
     0.0023   17.9   0.5     0.0036   17.3   0.5    1.3  1  LRR_5            BspA type Leucine rich repeat region (6 copi
     0.0035   17.4   0.3     0.0091   16.1   0.2    1.7  2  Acetyltransf_9   Acetyltransferase (GNAT) domain
  ------ inclusion threshold ------
      0.018   14.7   0.2      0.048   13.3   0.2    1.7  1  zf-P11           P-11 zinc finger
      0.043   14.0   0.7       0.11   12.6   0.2    1.8  2  Mss4             Mss4 protein
      0.045   13.3   0.1      0.085   12.4   0.1    1.4  1  GNAT_acetyltran  GNAT acetyltransferase
      0.058   13.3   0.0      0.091   12.7   0.0    1.3  1  LppA             Lipoprotein confined to pathogenic Mycobacte
      0.068   12.7   0.0      0.094   12.2   0.0    1.3  1  PNKP_ligase      PNKP adenylyltransferase domain, ligase doma


Domain annotation for each model (and alignments):
>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.9   0.0     2e-18   2.2e-15      33     117 .]      63     152 ..      27     152 .. 0.81

  Alignments for each domain:
  == domain 1  score: 56.9 bits;  conditional E-value: 2e-18
                     CEEEE.EEET.......TEEEEEEEEEEEETTSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHTTESEEEEEEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  33 egllv.aeed.......geliGfisllkipdekggvayieslaVspeyrgkGlGsaLlealeerareegikkivlaveedndaairlYeklGF 117
                     +g+l  +e +        ++i+ ++++k  +    +++++ ++ ++eyrgkGlG++Lle ++e+a+e ++k ++l++ +  + a +lYek+GF
      EFC38316.1  63 NGYLEiVELNsnsssieSKIIASCGIYKLSE---SKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYKQMELETASVLVEALALYEKFGF 152
                     3333334444556666688**********99...9******************************************999************9 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.0   0.1   4.8e-15   5.4e-12      12      75 ..      80     153 ..      55     154 .. 0.67

  Alignments for each domain:
  == domain 1  score: 46.0 bits;  conditional E-value: 4.8e-15
                     TEEEEEEEEEEES...TCTEEEEE-GGGTTSSHHHHHHH.HTT....SEEEEE.EEEETHH....HHHHHHHHTTEE CS
  Acetyltransf_7  12 gkivGfialslld...aeitrlaVdpeyrgkGiGraLle.aae....kgiile.qlelnae....kaikfYeklGFe 75 
                      ki+  ++++ l+   +e+ +++ ++eyrgkG+Gr+Lle a+e       + + q el++     +a+++Yek+GF 
      EFC38316.1  80 SKIIASCGIYKLSeskCELRKMYLREEYRGKGLGRKLLErAIEkakeM--N-YkQMELETAsvlvEALALYEKFGFS 153
                     455544444444455488888*****************9652233231..2.223344221235689*********7 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.2   0.0   1.5e-14   1.7e-11      43     109 ..      86     155 ..      75     166 .. 0.85

  Alignments for each domain:
  == domain 1  score: 44.2 bits;  conditional E-value: 1.5e-14
  Acetyltransf_10  43 vGviel.rdgshisllfVdpeyrgqGigkaLleaveeeaekdgikl.eltvnasp.yavpfYeklGFkav 109
                      +G+ +l +++ ++  ++ ++eyrg+G+g++Lle+++e+a+++++k+ el+  +   +a ++Yek+GF +v
       EFC38316.1  86 CGIYKLsESKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYKQmELETASVLvEALALYEKFGFSRV 155
                      377788555559*********************************88888888889***********988 PP

>> Acetyltransf_3  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.1   0.0   1.2e-09   1.3e-06       3     137 ..      13     152 ..      12     153 .. 0.76

  Alignments for each domain:
  == domain 1  score: 29.1 bits;  conditional E-value: 1.2e-09
  Acetyltransf_3   3 lLrplteeDlealfelrsdpevmry.lpe.pltleeaeewlera....waeeseeegygwaivl..kdtg......viGsvglrdleeedeeael 83 
                     ++r +te+D ++++e+++ + +++y l++ + + ++ ++ l ++    ++    ++gy  +++l  +  +      +i s+g+++l+e+   +el
      EFC38316.1  13 TFRAATEQDGPQILEMVT-QILTKYgLKQiQDPSDNIDDDLLNIekyyFT----NNGYLEIVELnsN--SssieskIIASCGIYKLSESK--CEL 98 
                     789999999999999666.5678897444444444445555555333333....4888777766542..22345537**********996..*** PP

  Acetyltransf_3  84 g.ymlapsfwgkGyateavralleyafeelglerlvavidkeNeaSirvleklGf 137
                       ++l+++++gkG+++  ++ ++e a +e+++++++ +++       +++ek Gf
      EFC38316.1  99 RkMYLREEYRGKGLGRKLLERAIEKA-KEMNYKQMELETASVLVEALALYEKFGF 152
                     94556677******************.9999***********************9 PP

>> Acetyltransf_4  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.2   3.6e-08     4e-05      75     137 ..      93     155 ..      14     162 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 3.6e-08
  Acetyltransf_4  75 dwkael.svylaerdnnkeglgrelidaleqvlkeqnienllaeiaspnensiqfhkalGFelv 137
                     + k+el ++yl  +  + +glgr+l++  ++ +ke+n+++++ e+as   ++ ++++++GF+ v
      EFC38316.1  93 ESKCELrKMYLR-EEYRGKGLGRKLLERAIEKAKEMNYKQMELETASVLVEALALYEKFGFSRV 155
                     4666664799*5.89**********************************************976 PP

>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   6.9e-08   7.8e-05      17      59 ..      89     130 ..      74     132 .. 0.87

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 6.9e-08
  Acetyltransf_CG  17 YevrkegvldfthTeVpeelrGkGiAkkLvkaalddareeglk 59 
                      Y+   e + ++ + +  ee+rGkG+++kL ++a+++a+e ++k
       EFC38316.1  89 YK-LSESKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYK 130
                      55.6677999999**************************9986 PP

>> Acetyltransf_15  Putative acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   1.7   1.6e-07   0.00018      32     107 ..      61     131 ..      26     174 .. 0.73

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.6e-07
  Acetyltransf_15  32 knenkydivqykkkeeLvasvfivkkkyyslvssilieknvleiYtlyvsekyrgkGlakklLeeslkelkkn.Ykv 107
                       n+ + +iv+ + +   + s  i  +  y+l++s        e+ ++y  e+yrgkGl +klLe+++++ k + Yk 
       EFC38316.1  61 TNNGYLEIVELNSNSSSIESKIIASCGIYKLSES------KCELRKMYLREEYRGKGLGRKLLERAIEKAKEMnYKQ 131
                      3334557777777777777777777777777763......3477789*******************99987542544 PP

>> FR47  FR47-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.0   5.2e-07   0.00058      21      80 ..      95     155 ..      79     160 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 5.2e-07
                 TSSEEEEEE-GGG-SSSHHHHHHHHHHHHHHH.S-S-EEEEEETT-HHHHHHHHHHT-EEE CS
        FR47  21 ggelgalqvlpehrrrGlgsrlvkalakeiae.rgktvllvvvasNtpsirlyeklGfeki 80 
                   el  +++++e r++Glg++l +  +++  e + k++ l ++    ++ +lyek Gf   
  EFC38316.1  95 KCELRKMYLREEYRGKGLGRKLLERAIEKAKEmNYKQMELETASVLVEALALYEKFGFSRV 155
                 578999*****************999999999667777788888899***********865 PP

>> PanZ  Acetyltransferase (GNAT) domain, PanZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   7.6e-07   0.00085      56     105 ..      90     139 ..      75     157 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 7.6e-07
        PanZ  56 eledkeaelsdlcVRevTRrRGVgsyLleearrqaPevkswvlaeedvke 105
                 +l++++ el+++  Re+ R +G g++Lle+a ++a e++  ++  e+ + 
  EFC38316.1  90 KLSESKCELRKMYLREEYRGKGLGRKLLERAIEKAKEMNYKQMELETASV 139
                 56778899***************************999999988887554 PP

>> LRR_5  BspA type Leucine rich repeat region (6 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.5   3.2e-06    0.0036      63     107 ..      47      91 ..      30     102 .. 0.83

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.2e-06
       LRR_5  63 tipssltsigeyaFsncsslkeitlpsnlttigssaFsncslesi 107
                 +i ++l +i++y F+n+  l+ ++l+sn ++i+s+++++c + ++
  EFC38316.1  47 NIDDDLLNIEKYYFTNNGYLEIVELNSNSSSIESKIIASCGIYKL 91 
                 577788889999999999999999999999999999988887765 PP

>> Acetyltransf_9  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       3.7   4.1e+03       2      18 ..      14      30 ..      13      37 .. 0.82
   2 !   16.1   0.2   8.1e-06    0.0091      83     126 ..     105     153 ..     101     155 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 3.7
                    EEEE-GGGHHHHHHHHH CS
  Acetyltransf_9  2 irelteedldevlellk 18
                    +r +te+d +++le++ 
      EFC38316.1 14 FRAATEQDGPQILEMVT 30
                    68999999999999876 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 8.1e-06
                     CCGTTS-HHHHHHHHHHHHHHHTT--EEEE--SSH.....HHHHTTT-E CS
  Acetyltransf_9  83 pehrgrgvlskLlaraleemreegqplsllfPssi.....piYrrfGye 126
                      e+rg+g+ +kLl+ra+e+++e++++   l  +s+     ++Y++fG++
      EFC38316.1 105 EEYRGKGLGRKLLERAIEKAKEMNYKQMELETASVlvealALYEKFGFS 153
                     69*********************998887777555555569******97 PP

>> zf-P11  P-11 zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.2   4.2e-05     0.048      12      33 ..     152     173 ..     149     174 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 4.2e-05
                 -SSEEE-SSSEEEHHHHHHHHH CS
      zf-P11  12 dksLveCsdHYLClrClqllLs 33 
                 +  ++ C+d  LC rC  ++++
  EFC38316.1 152 FSRVIDCEDKHLCSRCDIIMIK 173
                 6779*************99975 PP

>> Mss4  Mss4 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       1.5   1.7e+03      33      54 ..      51      65 ..      20      96 .. 0.58
   2 ?   12.6   0.2    0.0001      0.11      24      71 ..     122     169 ..     103     172 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.5
        Mss4 33 eselleefllvedvfdFdnvgv 54
                +  ++e++++ ++       g+
  EFC38316.1 51 DLLNIEKYYFTNN-------GY 65
                2233444444443.......33 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 0.0001
        Mss4  24 kksekeeqkeselleefllvedvfdFdnvgvskevesskyLiCAdCek 71 
                 +k ++++ k++el+++ +lve    ++  g+s+ ++  +  +C+ C++
  EFC38316.1 122 EKAKEMNYKQMELETASVLVEALALYEKFGFSRVIDCEDKHLCSRCDI 169
                 23567788899999***********************99999****96 PP

>> GNAT_acetyltran  GNAT acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   7.5e-05     0.085     165     236 ..      79     154 ..      75     157 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 7.5e-05
  GNAT_acetyltran 165 ngeivsgasSysvyekgiei.eidTkedyrrkgLAtivaaalileclkrgly.PsWDaa..neaSvaLaekLGYef 236
                      +++i++ +  y  +e++ e  +   +e+yr+kgL +++ ++ i+++ + ++   +  +a    +++aL+ek+G+ +
       EFC38316.1  79 ESKIIASCGIYKLSESKCELrKMYLREEYRGKGLGRKLLERAIEKAKEMNYKqMELETAsvLVEALALYEKFGFSR 154
                      6789999999999999999844777*********************997754167888877788999999999975 PP

>> LppA  Lipoprotein confined to pathogenic Mycobacterium
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   8.2e-05     0.091      85     120 ..      15      50 ..       6      64 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 8.2e-05
                 S---HHHHHHHHHHHHHHHHTTT--EEE-S-BSSS- CS
        LppA  85 gpipddqWpqaleiVrelAakygatevevfkDepgd 120
                  + ++++ pq+le+V+++  kyg+++++   D+ +d
  EFC38316.1  15 RAATEQDGPQILEMVTQILTKYGLKQIQDPSDNIDD 50 
                 5789***********************998887665 PP

>> PNKP_ligase  PNKP adenylyltransferase domain, ligase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   8.4e-05     0.094      40      71 ..     142     174 ..     126     176 .] 0.91

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 8.4e-05
                  HHHHHHHTTT--EEE.EEEE-SSEEEEEEEESS CS
  PNKP_ligase  40 eafeayrkegveevv.ceekHmGsRavvlvcrd 71 
                  ea++ y+k g ++v+ ce+kH+ sR  +++++d
   EFC38316.1 142 EALALYEKFGFSRVIdCEDKHLCSRCDIIMIKD 174
                  89************99**********9999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       714  (0.0398237); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1053.94
//
Query:       EFC38317.1  [L=163]
Description: hypothetical protein NAEGRDRAFT_74000 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.015   15.1   1.3       0.56   10.1   0.0    3.1  4  HTH_25           Helix-turn-helix domain
      0.015   15.2   0.0      0.027   14.3   0.0    1.4  1  F-box-like       F-box-like
      0.029   13.7   0.5      0.029   13.7   0.5    2.0  2  Put_Phosphatase  Putative Phosphatase
       0.04   13.8   0.9      0.062   13.2   0.1    1.7  2  F-box            F-box domain
      0.055   13.8   0.1      0.055   13.8   0.1    2.7  3  PRANC            PRANC domain
      0.083   11.8   0.1       0.12   11.3   0.1    1.4  1  Glyco_hydro_79n  Glycosyl hydrolase family 79, N-terminal dom
       0.34   10.7   6.6      0.042   13.6   2.1    1.7  2  HD_2             HD containing hydrolase-like enzyme
        2.2    8.3  21.3       0.14   12.1   3.2    2.3  2  CENP-F_leu_zip   Leucine-rich repeats of kinetochore protein 
          9    6.8  12.3       0.84   10.1   2.3    3.1  3  FlaC_arch        Flagella accessory protein C (FlaC)
        9.3    6.1  11.9      4e+02    0.7  11.9    2.1  1  PCRF             PCRF domain


Domain annotation for each model (and alignments):
>> HTH_25  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.5   2.7e+03      10      25 ..      18      33 ..      17      38 .. 0.81
   2 ?   10.1   0.0   0.00031      0.56      38      59 ..      39      60 ..      29      63 .. 0.87
   3 ?    2.0   0.4       0.1   1.8e+02      12      32 ..      65      85 ..      60      90 .. 0.88
   4 ?   -2.2   0.0       2.1   3.8e+03      25      34 ..     102     111 ..      94     113 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.5
                T--HHHHHHHSS--HH CS
      HTH_25 10 glsleevaketkIrkd 25
                +ls++ + + + I k+
  EFC38317.1 18 NLSVKHLKNILSINKS 33
                6899999999999876 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00031
                SS-HHHHHHHHHHHHHHTT--H CS
      HTH_25 38 lpepvylrgylrnYArlLgldp 59
                  ++++ r +++nY +lLg d+
  EFC38317.1 39 VQSETFWRTLIKNYSKLLGSDS 60
                45789**************986 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.1
                -HHHHHHHSS--HHHHHHHHC CS
      HTH_25 12 sleevaketkIrkdylealEe 32
                s++e+ +   I+k+ +e +E 
  EFC38317.1 65 SVQELLEIAEIKKKFIELIEM 85
                8899999999*********96 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 2.1
                 HHHHHHHCT- CS
      HTH_25  25 dylealEedd 34 
                  +l++lE d+
  EFC38317.1 102 YMLRELEMDQ 111
                 4688898876 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   1.5e-05     0.027       3      45 ..       6      48 ..       4      50 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.5e-05
  F-box-like  3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrl 45
                +LP E+ ++IFs L+ + L ++    ++ ++       +Wr+l
  EFC38317.1  6 DLPSELQIEIFSNLSVKHLKNILSINKSTHEQLVQSETFWRTL 48
                8******************997777666665554455777776 PP

>> Put_Phosphatase  Putative Phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.5   1.6e-05     0.029      29      92 ..      34      95 ..      13      99 .. 0.81
   2 ?    0.8   0.2      0.15   2.7e+02      42      71 ..     132     161 ..     101     163 .] 0.79

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.6e-05
  Put_Phosphatase 29 lfeelretlrkglwnelmdrvlkelheqgvseadikkvlrsiplspglvelikslakkkleldl 92
                     + e+l ++  +++w +l+++  k l+++ + e+++++ l+   ++ +++eli++ +++++e+++
       EFC38317.1 34 THEQLVQS--ETFWRTLIKNYSKLLGSDSRVEKSVQELLEIAEIKKKFIELIEMKKRNTEEFQM 95
                     33444443..47*******************************************999999876 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.15
  Put_Phosphatase  42 wnelmdrvlkelheqgvseadikkvlrsip 71 
                       n  m+r+ +e ++ ++++++i++ lr++ 
       EFC38317.1 132 LNIGMERMKQECENVKKEKEEIEEKLRKLI 161
                      566689999999999999999999999875 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.1   3.4e-05     0.062       2      25 ..       3      26 ..       2      36 .. 0.84
   2 ?   -3.0   0.0         4   7.2e+03      33      39 ..      45      51 ..      43      54 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.4e-05
                HHHHS-HHHHHHHHHTS-HHHHHH CS
       F-box  2 tlsrLPsevlrhILerLplsdlla 25
                ++ +LPse+  +I+++L+ ++l +
  EFC38317.1  3 NFVDLPSELQIEIFSNLSVKHLKN 26
                5779**************999755 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4
                HHHHHTT CS
       F-box 33 wrilids 39
                wr li++
  EFC38317.1 45 WRTLIKN 51
                9999986 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   3.1e-05     0.055      72      96 ..       4      28 ..       1      29 [. 0.90
   2 ?    0.6   0.8       0.4   7.1e+02      39      68 ..      60      89 ..      30     111 .. 0.61
   3 ?   -1.6   0.1       1.9   3.5e+03      40      60 ..     138     158 ..     127     161 .. 0.59

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 3.1e-05
       PRANC 72 WnlLPiEIkykIleyLndkdLknll 96
                   LP E++++I+++L+ k+Lkn+l
  EFC38317.1  4 FVDLPSELQIEIFSNLSVKHLKNIL 28
                568********************97 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.4
       PRANC 39 klikkiiksakkrykliekaievlnnicsk 68
                ++++k+++++ +  ++ +k ie ++ + ++
  EFC38317.1 60 SRVEKSVQELLEIAEIKKKFIELIEMKKRN 89
                455666666666666666666666655555 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 1.9
       PRANC  40 likkiiksakkrykliekaie 60 
                 ++k+  +++kk ++ ie+ ++
  EFC38317.1 138 RMKQECENVKKEKEEIEEKLR 158
                 455555666666666655544 PP

>> Glyco_hydro_79n  Glycosyl hydrolase family 79, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   6.7e-05      0.12      55      96 ..     111     152 ..      61     157 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6.7e-05
  Glyco_hydro_79n  55 anaikafsplrirlGGslqdkvvyevgekkkpckefkkkede 96 
                      ++ ++a ++  + lGG++ d++   ++++k++c+++kk+++e
       EFC38317.1 111 QREMQARNESVLLLGGTISDQLNIGMERMKQECENVKKEKEE 152
                      4567788888999*************************9887 PP

>> HD_2  HD containing hydrolase-like enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   2.1   2.3e-05     0.042     102     170 ..      42     111 ..      18     119 .. 0.81
   2 ?   -1.5   0.2      0.99   1.8e+03      83     162 ..     144     156 ..     129     162 .. 0.46

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.3e-05
        HD_2 102 elLpeelreeyeella.deeaeeeekklvkaaDklsalikcleelkagnkeFeeakkeieeklkelelpe 170
                 e+    l ++y++ll+ d++ e+++++l+++a   + +i+ +e +k + +eF+ +  +++  l+ele+++
  EFC38317.1  42 ETFWRTLIKNYSKLLGsDSRVEKSVQELLEIAEIKKKFIELIEMKKRNTEEFQMTSLKLKYMLRELEMDQ 111
                 3556778899*****66999999**********************999999*************998875 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.99
        HD_2  83 peireaykevEeeaeekllelLpeelreeyeelladeeaeeeekklvkaaDklsalikcleelkagnkeFeeakkeieek 162
                 ++++                                                                   + k+eieek
  EFC38317.1 144 ENVK-------------------------------------------------------------------KEKEEIEEK 156
                 2222...................................................................222222222 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2  10.2     0.093   1.7e+02      68     125 ..      62     119 ..      20     125 .. 0.78
   2 ?   12.1   3.2   8.1e-05      0.14      42      73 ..     131     162 ..     122     163 .] 0.89

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.093
  CENP-F_leu_zip  68 lreleldLvalrsekeeLekelqkkqervseLeslnsslenlleekEqekvqmkeesk 125
                      ++  ++L ++ + k++  + ++ k++  +e +++ ++l+ +l+e+E+++++m+ + +
      EFC38317.1  62 VEKSVQELLEIAEIKKKFIELIEMKKRNTEEFQMTSLKLKYMLRELEMDQREMQARNE 119
                     4555677888888888998999999999999999999999999999999999987765 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 8.1e-05
  CENP-F_leu_zip  42 kvileaEtskaevetlkeeieelaeelrelel 73 
                     ++ + +E  k+e+e++k+e+ee++e+lr+l +
      EFC38317.1 131 QLNIGMERMKQECENVKKEKEEIEEKLRKLII 162
                     667789**********************9965 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.3      0.12   2.1e+02      29      45 ..      58      74 ..      33      85 .. 0.70
   2 ?    0.1   0.3      0.61   1.1e+03      15      30 ..     106     121 ..      84     134 .. 0.56
   3 ?   10.1   2.3   0.00047      0.84      12      41 ..     132     161 ..     128     162 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.12
   FlaC_arch 29 sveelkenVkdllsLYE 45
                s  +++++V++ll++ E
  EFC38317.1 58 SDSRVEKSVQELLEIAE 74
                55567778888877654 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.61
   FlaC_arch  15 eletvkkeneelsksv 30 
                 ele+ ++e++  ++sv
  EFC38317.1 106 ELEMDQREMQARNESV 121
                 4444444444444444 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.00047
   FlaC_arch  12 lsteletvkkeneelsksveelkenVkdll 41 
                 l + +e +k+e e+++k+ ee++e+ ++l+
  EFC38317.1 132 LNIGMERMKQECENVKKEKEEIEEKLRKLI 161
                 667888999999999999999999999986 PP

>> PCRF  PCRF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7  11.9      0.22     4e+02      11      90 ..      38     122 ..      28     163 .] 0.45

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.22
                 ST.-GGGTTT.GGGSSSTTHHHHHTHHHHHHHHHHHHHTTTHHH...HT.....-S-..-GG....GTHHHHHHHHHH..HHHHHT CS
        PCRF  11 klsdpevwed.qekakklskelaeleeivealeeleealedleeakelle.edeelaelaee....eleelekeleeleeelkklL 90 
                  ++++++w+   ++++kl  + +++e+ v++l e+ e +++  e+ e+ + + ee++ + +      l+ele + +e++++ +++L
  EFC38317.1  38 LVQSETFWRTlIKNYSKLLGSDSRVEKSVQELLEIAEIKKKFIELIEMKKrNTEEFQ-MTSLklkyMLRELEMDQREMQARNESVL 122
                 455555555434556666666666666666666666666666665555432222222.2111112223333333333333322222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2313  (0.129009); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1009.64
//
Query:       EFC38318.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1990  (0.110993); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 1682.34
//
Query:       EFC38319.1  [L=948]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.1e-22   78.4   0.1    4.1e-22   78.4   0.1    3.2  3  DSPc             Dual specificity phosphatase, catalytic doma
    1.7e-16   60.4   0.0    4.4e-16   59.0   0.0    1.7  1  Lipase_3         Lipase (class 3)
    3.6e-05   23.4   0.0    7.9e-05   22.3   0.0    1.5  1  Y_phosphatase    Protein-tyrosine phosphatase
    0.00062   19.4   0.0     0.0017   17.9   0.0    1.7  1  DUF2974          Protein of unknown function (DUF2974)
  ------ inclusion threshold ------
      0.048   13.3   0.1       0.11   12.1   0.1    1.6  1  CDKN3            Cyclin-dependent kinase inhibitor 3 (CDKN3)
       0.06   13.3   0.2       0.19   11.6   0.2    1.9  1  Pdase_C33_assoc  Peptidase_C33-associated domain
      0.067   13.5   0.1       0.33   11.3   0.0    2.2  2  Init_tRNA_PT     Rit1 DUSP-like domain


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.27   6.8e+02      50      79 ..     376     405 ..     332     413 .. 0.76
   2 ?   -1.2   0.5      0.66   1.7e+03      35      72 ..     681     718 ..     649     725 .. 0.46
   3 !   78.4   0.1   1.6e-25   4.1e-22      17     127 ..     833     945 ..     813     947 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.27
                 STTSCCGGGHHHHHHHHHHHHHTT-EEEEE CS
        DSPc  50 ehetkiskyleeavefidkakqkgkkvlVH 79 
                 e+++ i+k+l +++ f++++k++  k+ + 
  EFC38319.1 376 ENSKMIEKQLGKSTYFVSDMKDRSFKIHIS 405
                 5778899**************999999875 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.66
                 CTTTTSEEEEECCESSTTSCCGGGHHHHHHHHH.HHHHT CS
        DSPc  35 lkkseieklripvedehetkiskyleeavefid.kakqk 72 
                 lk +e++   + +   + ++i+k+l + +  i+  a+++
  EFC38319.1 681 LKANEKNTNAVTMIS-RFNEIRKELTKQKVTIAiHAEND 718
                 223333333333222.44455555555555555444555 PP

  == domain 3  score: 78.4 bits;  conditional E-value: 1.6e-25
                 HTCSEEEEESSSSSECECCTTTTSEEEEECCESSTTSCCGGGHHHHHHHHHHH..HHTT-EEEEEESSSSSHHHHHHHHHHHHHHTSCHHHHHH.HHHH CS
        DSPc  17 lgitlvinvtkevpnanalkkseieklripvedehetkiskyleeavefidka..kqkgkkvlVHCqaGisRSatliiaYlmktknlslneaye.flke 112
                 +++t++  +     + +  k+s+ie+ +i+  d    +i+k+ ++  efid+a   +++++vlVHC  G+sRSa++++aYlm +k+++ +eay+  +k+
  EFC38319.1 833 YKFTHICVCGFGLIK-KHEKTSQIEYYHIKAVDLPVYNITKDVKSCAEFIDNAlnGDENNRVLVHCSRGVSRSASIVTAYLMLKKGMTFEEAYYgNVKK 930
                 566666666555444.44599*********9999*******************777799*********************************86379** PP

                 HSTT-SSTHHHHHHH CS
        DSPc 113 rrpaispnagfirqL 127
                 +r+ ++ n gf +qL
  EFC38319.1 931 KRSIVCLNQGFAEQL 945
                 **************9 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.0   0.0   1.7e-19   4.4e-16       1     134 [.      76     198 ..      76     203 .. 0.91

  Alignments for each domain:
  == domain 1  score: 59.0 bits;  conditional E-value: 1.7e-19
                 EEEE----------------EEE-HHHH-GTT-EEEHHHHHHHHS-HHHHHHHHHHHHHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS---EEE CS
    Lipase_3   1 vvafRGtesakdwltdldfslteakellekeggkvhsgfleayeeslreqvlkelkrllekypeysivvtGHSLGgalAlLaaldlvengenekkkvtv 99 
                 +vaf+G+e+ +d+l++l++ +t+++e     +g+ h+gf   +    ++q+   ++ l + y+   +v++GHS+Gg+lA Laa+ + + ++++k+ v +
  EFC38319.1  76 YVAFKGSETVSDILANLNCFPTSLEES----NGSYHRGFSAKIS---AMQMNFFIDYLDKGYK---VVFCGHSIGGSLAGLAAIRVLHSKPKKKEHVYC 164
                 69************************7....9*******99988...7777777777766665...********************************* PP

                 EEES----B-HHHHHHHHT-TTEEEEEEEETT--G CS
    Lipase_3 100 vtfGqPrvgnkefaklvdsqlnkkvlrvvntnDiv 134
                 v fG+P   ++ +++++++  +k++l + +++D+v
  EFC38319.1 165 VGFGAPLFASSVVKEEISK-YSKQFLWFLYEKDLV 198
                 ******************5.5555*********98 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.0   3.1e-08   7.9e-05     126     196 ..     848     916 ..     821     933 .. 0.83

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 3.1e-08
                    TTTTEEEEEEEEEEESSS-SSSSGSCCHHHHHHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHHHHHHHH CS
  Y_phosphatase 126 kkeeseerevkqlqytnWpdhgvpesaksllklirkvekskeaksgpvvVhCsaGvgRtgtfvaldillqq 196
                    k e++ + e ++++  + p  ++ ++ ks  ++i+++ +    +++ v+VhCs Gv+R++++v++ ++l++
     EFC38319.1 848 KHEKTSQIEYYHIKAVDLPVYNITKDVKSCAEFIDNALNGD--ENNRVLVHCSRGVSRSASIVTAYLMLKK 916
                    333334556677777788889999***********999999..89********************999986 PP

>> DUF2974  Protein of unknown function (DUF2974)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   6.8e-07    0.0017      55     140 ..     100     187 ..      65     211 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 6.8e-07
     DUF2974  55 edfnmafrsevpaqesAlkYlnkileeseg..kiylgGhSkGGnlAvyaamnaeddlqeriskiys..fDgpGfskevveseeykkiksk 140
                 e+ n ++++  +a++sA++  n +++  ++  k++ +GhS GG+lA +aa+++ ++  ++ +++y+  f +p f ++vv++e ++k +++
  EFC38319.1 100 EESNGSYHRGFSAKISAMQM-NFFIDYLDKgyKVVFCGHSIGGSLAGLAAIRVLHSKPKKKEHVYCvgFGAPLFASSVVKEE-ISKYSKQ 187
                 67788999999999999884.3333443333459******************555555566666652267888888888744.4555555 PP

>> CDKN3  Cyclin-dependent kinase inhibitor 3 (CDKN3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.1   4.4e-05      0.11     112     156 ..     870     914 ..     838     923 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.4e-05
                 S---HHHHHHHHHHHHHHHHTT--EEEE-SSSSSHHH.HHHHHHHH CS
       CDKN3 112 gtpdiascleimeelatclknyrktlihcygglgrsc.lvaaclll 156
                  t d+ sc e +++     +n+r  l+hc  g+ rs+ +v+a l+l
  EFC38319.1 870 ITKDVKSCAEFIDNALNGDENNR-VLVHCSRGVSRSAsIVTAYLML 914
                 589*********99888877776.89*********97245555555 PP

>> Pdase_C33_assoc  Peptidase_C33-associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.2   7.6e-05      0.19      68      98 ..      13      43 ..       3      81 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 7.6e-05
  Pdase_C33_assoc 68 dqvclgkiislcqviedcccsqnktnrvtpe 98
                     d    + iis c ++ dcc sq+ ++++   
       EFC38319.1 13 DIHISKEIISTCAILSDCCYSQDPVEHIGNY 43
                     4444567****************99887654 PP

>> Init_tRNA_PT  Rit1 DUSP-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       4.8   1.2e+04      13      47 ..     377     409 ..     371     427 .. 0.68
   2 ?   11.3   0.0   0.00013      0.33      16      61 ..     869     914 ..     848     933 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.8
  Init_tRNA_PT  13 gsknLrtalpkivdfvrkrlsedkkkkilvacetG 47 
                   +sk ++++l k + fv++   ++   ki ++  +G
    EFC38319.1 377 NSKMIEKQLGKSTYFVSDMKDRS--FKIHISDRNG 409
                   57778888888888888874443..4565555555 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00013
  Init_tRNA_PT  16 nLrtalpkivdfvrkrlsedkkkkilvacetGkdlsvgvaLailck 61 
                   n+ + ++++ +f+ + l+ d+++++lv+c  G + s++++ a l+ 
    EFC38319.1 869 NITKDVKSCAEFIDNALNGDENNRVLVHCSRGVSRSASIVTAYLML 914
                   66788999************************99999999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (948 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       794  (0.0442858); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.80u 0.29s 00:00:01.09 Elapsed: 00:00:00.47
# Mc/sec: 6025.11
//
Query:       EFC38320.1  [L=460]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.1e-09   35.2   0.1    1.8e-08   33.9   0.1    1.7  1  HipN            Hsp70-interacting protein N N-terminal domain
    3.9e-08   32.8   2.9       0.14   12.4   0.3    3.6  4  TPR_2           Tetratricopeptide repeat
    4.3e-08   32.6   6.3       0.11   12.3   1.4    3.4  3  TPR_1           Tetratricopeptide repeat
    4.4e-06   26.7   0.4     0.0026   18.0   0.2    2.9  2  TPR_17          Tetratricopeptide repeat
     0.0011   19.1   0.6      0.065   13.3   0.1    3.4  3  HECW1_helix     Helical box domain of E3 ubiquitin-protein li
     0.0036   17.2   0.3      0.016   15.1   0.0    2.3  2  STI1            STI1 domain
     0.0047   16.6   6.3      0.017   14.8   0.6    2.4  2  TPR_11          TPR repeat
     0.0057   17.3   0.1      0.073   13.7   0.1    2.1  2  TPR_16          Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.014   15.6   4.9       0.65   10.4   0.1    3.4  3  TPR_8           Tetratricopeptide repeat
        1.6    8.8  10.3       0.19   11.7   1.8    2.3  2  Neur_chan_memb  Neurotransmitter-gated ion-channel transmembr
          4    7.0  13.6      0.074   12.7   3.3    2.1  2  CCDC84          Coiled coil protein 84


Domain annotation for each model (and alignments):
>> HipN  Hsp70-interacting protein N N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   0.1   1.1e-11   1.8e-08       3      39 ..       9      47 ..       8      48 .. 0.84

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 1.1e-11
        HipN  3 aklseLkqFVklckanPeiLh.ePeLaFFKefl.eslGa 39
                ++l  LkqFVk +k nP +L  ++eLaFFK+fl  + Ga
  EFC38320.1  9 SQLDSLKQFVKYIKYNPRVLDdSEELAFFKDFLiNDCGA 47
                58999***************6479********7245565 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       7.5   1.2e+04      20      32 ..      13      25 ..      12      26 .. 0.83
   2 !   12.4   0.3   8.4e-05      0.14       4      30 ..     205     231 ..     202     234 .. 0.88
   3 !    7.7   0.0    0.0026       4.3       5      33 ..     241     269 ..     237     270 .. 0.90
   4 !   11.1   0.1   0.00021      0.34       2      25 ..     272     295 ..     271     303 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 7.5
       TPR_2 20 AleafekAleldP 32
                 l+ f k ++++P
  EFC38320.1 13 SLKQFVKYIKYNP 25
                5788999999999 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 8.4e-05
       TPR_2   4 lynlGlayyklgdyeeAleafekAlel 30 
                 +   G+ ++k+++y+ A+ ++ kA+e 
  EFC38320.1 205 CTKKGNDLFKKNEYQLAAIYYGKAIEC 231
                 5678*********************85 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0026
       TPR_2   5 ynlGlayyklgdyeeAleafekAleldPn 33 
                   ++++++ ++++   ++++++A++l+P+
  EFC38320.1 241 IKRAECLAMMNKPLSVRRDCDQAIKLNPD 269
                 679999999999999*************8 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00021
       TPR_2   2 ealynlGlayyklgdyeeAleafe 25 
                 +a++ +G+a+++lg+ + A++++e
  EFC38320.1 272 KAYNLRGKALLALGKVDLAKKDLE 295
                 79*******************998 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   1.4     7e-05      0.11       4      29 ..     205     230 ..     202     232 .. 0.90
   2 !    9.3   0.0   0.00064         1       5      33 ..     241     269 ..     237     270 .. 0.87
   3 !   12.2   0.2   7.9e-05      0.13       2      25 ..     272     295 ..     271     303 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 7e-05
                 HHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   4 lynlGnayfklgkydeAleyyekALe 29 
                 +  +Gn +fk+++y+ A  yy kA+e
  EFC38320.1 205 CTKKGNDLFKKNEYQLAAIYYGKAIE 230
                 6779*********************8 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00064
                 HHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   5 ynlGnayfklgkydeAleyyekALelnPn 33 
                   ++ ++  ++k+     ++++A++lnP+
  EFC38320.1 241 IKRAECLAMMNKPLSVRRDCDQAIKLNPD 269
                 568999999999999999**********8 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 7.9e-05
                 HHHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyye 25 
                 ka++ +G a++ lgk d A ++ e
  EFC38320.1 272 KAYNLRGKALLALGKVDLAKKDLE 295
                 79*******************987 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0     0.014        23       1      28 [.     224     252 ..     224     255 .. 0.89
   2 !   18.0   0.2   1.6e-06    0.0026       2      33 ..     260     291 ..     259     292 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.014
      TPR_17   1 lylkalel.dPnnadaynnLAelllknGd 28 
                 +y ka+e+ +  +a  +  +Ae+l++ ++
  EFC38320.1 224 YYGKAIECsNGESAMTFIKRAECLAMMNK 252
                 589*****8899************98876 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 1.6e-06
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlmtAr 33 
                 + +a++l+P+  +ayn+++++ll +G+ + A+
  EFC38320.1 260 CDQAIKLNPDAGKAYNLRGKALLALGKVDLAK 291
                 679************************99987 PP

>> HECW1_helix  Helical box domain of E3 ubiquitin-protein ligase HECW1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.17   2.7e+02       5      27 ..      45      66 ..      41      74 .. 0.79
   2 ?   -1.5   0.0       1.8   2.9e+03      16      31 ..     260     275 ..     234     279 .. 0.71
   3 !   13.3   0.1     4e-05     0.065      27      66 ..     413     451 ..     390     452 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.17
  HECW1_helix  5 spavkfitrPdflsvlhsnqeAl 27
                   a+kf++ P f++ ++s+++  
   EFC38320.1 45 CGATKFVSTP-FVNNVSSPSSST 66
                 6799******.**9999988765 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.8
  HECW1_helix  16 flsvlhsnqeAlrvyn 31 
                    + ++ n +A ++yn
   EFC38320.1 260 CDQAIKLNPDAGKAYN 275
                  4456777777777776 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 4e-05
  HECW1_helix  27 lrvynknsilkhmvskirrdpekferYqhnrdlVallNlF 66 
                  +r  ++n+ l   ++ i  +p++f +Y+h+ ++V++  +F
   EFC38320.1 413 MRG-FQNPRLVNAINEIAMNPSAFLKYNHDIEVVTMFKKF 451
                  444.4678888899**********************9998 PP

>> STI1  STI1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       8.1   1.3e+04      19      28 ..     177     186 ..     176     188 .. 0.74
   2 !   15.1   0.0   9.8e-06     0.016      11      52 ..     409     450 ..     399     452 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 8.1
        STI1  19 sDPefvakle 28 
                 sD++++++++
  EFC38320.1 177 SDSKYMSIMN 186
                 5788888875 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 9.8e-06
        STI1  11 nPetrellsDPefvakleeiqsNPqalqqymsDprimtvlsv 52 
                 +  +++ +++P +v+ ++ei+ NP+a+ +y +D ++ t++ +
  EFC38320.1 409 DEYLMRGFQNPRLVNAINEIAMNPSAFLKYNHDIEVVTMFKK 450
                 555667789*****************************9986 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.6     0.017        28       1      22 [.     209     230 ..     209     233 .. 0.93
   2 !   14.8   0.6     1e-05     0.017      19      42 .]     262     285 ..     261     285 .. 0.96

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.017
      TPR_11   1 GdayyeqGkyeeAieaYkkAlk 22 
                 G+ ++++++y  A   Y kA++
  EFC38320.1 209 GNDLFKKNEYQLAAIYYGKAIE 230
                 99******************98 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 1e-05
      TPR_11  19 kAlkldPdnaeayynLGlayykqG 42 
                 +A+kl+Pd   ay+ +G+a++++G
  EFC38320.1 262 QAIKLNPDAGKAYNLRGKALLALG 285
                 9*******************9998 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.37   6.1e+02       4      59 ..     209     227 ..     206     236 .. 0.55
   2 !   13.7   0.1   4.5e-05     0.073      21      53 ..     261     290 ..     257     294 .. 0.94

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.37
      TPR_16   4 araalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyra 59 
                 ++++++ ++y+ Aa                                      +y +
  EFC38320.1 209 GNDLFKKNEYQLAA-------------------------------------IYYGK 227
                 55555555555555.....................................44433 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 4.5e-05
      TPR_16  21 eaalkrdpssPdaaeAllllgdaalrqgrlaeA 53 
                 ++a+k++   Pda  A++l+g a+l++g +++A
  EFC38320.1 261 DQAIKLN---PDAGKAYNLRGKALLALGKVDLA 290
                 69*****...*******************9988 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.5      0.02        32      11      29 ..     212     230 ..     205     233 .. 0.85
   2 ?   -0.6   0.0       1.3   2.2e+03      24      33 ..     260     269 ..     258     269 .. 0.85
   3 ?   10.4   0.1    0.0004      0.65       2      25 ..     272     295 ..     271     303 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.02
                 HHHTT-HHHHHHHHHHHHH CS
       TPR_8  11 ylklgdyeeAkeyyekale 29 
                 ++k+++y+ A  yy ka+e
  EFC38320.1 212 LFKKNEYQLAAIYYGKAIE 230
                 789**************98 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.3
                 HHHHHHHHHH CS
       TPR_8  24 yekaleldpd 33 
                 + +a++l+pd
  EFC38320.1 260 CDQAIKLNPD 269
                 579*****97 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.0004
                 CHHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyye 25 
                 +ay++ g+++l lg+ + Ak+ +e
  EFC38320.1 272 KAYNLRGKALLALGKVDLAKKDLE 295
                 79*******************997 PP

>> Neur_chan_memb  Neurotransmitter-gated ion-channel transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   1.6      0.14   2.3e+02     141     214 ..      98     182 ..      23     221 .. 0.51
   2 ?   11.7   1.8   0.00012      0.19      98     173 ..     239     379 ..     232     429 .. 0.60

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.14
                     -...........-------------------SS---TTGGG--.....-----TTTTTHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Neur_chan_memb 141 e...........skkaklseeqgsekastckckckegeeaspstqlskeelspelkkavegvkyiadhlraededksvkedwkyv 214
                     +           ++++k ++ +++ek+  +++++ ++++a ++   ++ + sp++  + e ++   + ++ e+e+   + d ky+
      EFC38320.1  98 KslileiddqqvTNDKKENKPPVEEKNVMKEMTNVRESTAINNGYVEETSNSPKIPLISEPTATKEKIIEPEKETVLTNSDSKYM 182
                     0222112112223333333333333444444444344444333333335555555555555544445555444444444444443 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00012
                     HTTHHHHHHC--------------...................................................................---- CS
  Neur_chan_memb  98 vfldklprllfmkrpsevkdnekkl..................................................................ssga 126
                      f+++ + l +m++p +v++++++                                                                   ++ +
      EFC38320.1 239 TFIKRAECLAMMNKPLSVRRDCDQAiklnpdagkaynlrgkallalgkvdlakkdlemfkqlnsdisnmdkvdklidqindirsvekkeenPTTT 333
                     6899999999*****99999999999999999999999999999999999999999999999888888888888888777776555444431111 PP

                     ----------------------------------SS---TTGGG--. CS
  Neur_chan_memb 127 sseaeelilskskseskkaklseeqgsekastckckckegeeaspst 173
                     +s+++ +++s + ++ + ++  ++   +k+st +  +++++ ++p +
      EFC38320.1 334 TSNTATTKQSTPPQQQQSSTTYSQTT-QKSSTTSSSTSSNSSSKPTN 379
                     11222222222222111111111111.11111111111122222222 PP

>> CCDC84  Coiled coil protein 84
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   2.7      0.37     6e+02     117     175 ..      74     163 ..      40     241 .. 0.43
   2 ?   12.7   3.3   4.5e-05     0.074     109     220 ..     286     385 ..     274     423 .. 0.52

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.37
      CCDC84 117 vekfkkkve...............kdl..esteekedefekeeaasiketesnrvevlqslleeeaqises.....lgsl................a 175
                  e+fk++++               k l  e   +++ + +ke+   ++e++  +      +++ ++++  +        +                 
  EFC38320.1  74 QEQFKEELQeeeepegflikevktKSLilEIDDQQVTNDKKENKPPVEEKNVMKE-----MTNVRESTAINngyveE--TsnspkipliseptatkE 163
                 3444444444444444444333332211222222222222222222222222111.....11111111111111110..011222222222222210 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 4.5e-05
      CCDC84 109 kfriseedvekfkkkvekdlesteekedefekeeaasiketesnrvevlqslleeeaqiseslgslaelletrkqqsalleslkesaskkstleestsv 207
                 k+ ++++d+e+fk+ +++d+  +++k+d+ + ++++ i+++e+++ ++  ++ +++++ +++        + ++qqs+++ s+++++s+++++++s+++
  EFC38320.1 286 KVDLAKKDLEMFKQ-LNSDIS-NMDKVDKLI-DQINDIRSVEKKEENPTTTTSNTATTKQST--------PPQQQQSSTTYSQTTQKSSTTSSSTSSNS 373
                 55666777777754.444663.344555554.678999999999998866666664443333........22333333333333222222222222333 PP

      CCDC84 208 lqnpkgshqqags 220
                 +++p++s+  +++
  EFC38320.1 374 SSKPTNSN-SSNN 385
                 33332222.1111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2458  (0.137096); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        95  (0.00529868); expected 17.9 (0.001)
Passed Fwd filter:                        29  (0.00161749); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.85u 0.39s 00:00:01.24 Elapsed: 00:00:00.57
# Mc/sec: 2427.96
//
Query:       EFC38321.1  [L=343]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      8e-26   88.7  11.0      8e-05   22.5   0.1    6.7  6  NHL           NHL repeat
      8e-10   38.7   1.9    2.5e-06   27.3   0.4    3.0  3  SGL           SMP-30/Gluconolactonase/LRE-like region
    0.00096   19.3   0.7       0.29   11.3   0.0    3.9  5  Arylesterase  Arylesterase
     0.0019   18.2   0.1        0.3   11.1   0.0    2.9  2  DUF5074       Domain of unknown function (DUF5074)
     0.0038   16.5   0.0       0.33   10.2   0.0    2.8  3  Lactonase     Lactonase, 7-bladed beta-propeller
     0.0056   16.7   4.7         15    6.2   0.0    6.0  6  Reg_prop      Two component regulator propeller
  ------ inclusion threshold ------
      0.012   15.7   0.0         18    5.5   0.0    3.7  4  Str_synth     Strictosidine synthase
      0.029   14.3   0.0        8.9    6.2   0.0    3.3  3  Phytase-like  Esterase-like activity of phytase
      0.029   14.6   2.9         10    6.5   0.0    3.7  3  TRL           TRL-like protein family
      0.045   13.1  10.5      0.096   12.0   0.1    4.6  5  LVIVD         LVIVD repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   4.1e-06    0.0074      13      27 ..      25      39 ..      21      40 .. 0.90
   2 !    8.7   0.5    0.0011       1.9       2      27 ..      69      95 ..      69      96 .. 0.93
   3 !   22.5   0.1   4.4e-08     8e-05       1      27 [.     125     152 ..     125     153 .. 0.94
   4 !    9.6   0.0   0.00056         1       2      27 ..     188     213 ..     188     214 .. 0.94
   5 !   22.2   0.1   5.3e-08   9.5e-05       1      27 [.     244     270 ..     244     271 .. 0.95
   6 !   11.0   0.0   0.00019      0.34      12      26 ..     297     311 ..     286     311 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.1e-06
                TEEEEEECCCTEEEE CS
         NHL 13 GdiyVaDsenhrvqv 27
                +++y+aD+enh++++
  EFC38321.1 25 DEVYIADTENHCIRK 39
                68***********97 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0011
                SSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL  2 nyPhGvavd.snGdiyVaDsenhrvqv 27
                n P +v v+  nG++y +D +n+r+++
  EFC38321.1 69 NKPVCVIVNhRNGNVYFSDLGNNRIRK 95
                579999*******************87 PP

  == domain 3  score: 22.5 bits;  conditional E-value: 4.4e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P+G++++ +++ +y+aD+ nh +++
  EFC38321.1 125 LNSPRGICLSnDGNYLYIADRDNHAIRK 152
                 799*******99999*********9986 PP

  == domain 4  score: 9.6 bits;  conditional E-value: 0.00056
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n+P G+a+++++++y +++ nh++++
  EFC38321.1 188 NCPYGIAISKDDELYFSEFSNHTIRK 213
                 6899*******************987 PP

  == domain 5  score: 22.2 bits;  conditional E-value: 5.3e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+ ++ d+n+++y+aD+ n+++++
  EFC38321.1 244 LNYPAYICFDNNNNLYIADRDNNSIRK 270
                 79**********************987 PP

  == domain 6  score: 11.0 bits;  conditional E-value: 0.00019
                 TTEEEEEECCCTEEE CS
         NHL  12 nGdiyVaDsenhrvq 26 
                 n+ +y+aD+ nh+++
  EFC38321.1 297 NNILYIADTDNHQIK 311
                 789**********95 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.038        68       9     214 ..      78     100 ..      21     109 .. 0.71
   2 !   27.3   0.4   1.4e-09   2.5e-06      94     218 ..      78     222 ..      75     233 .. 0.81
   3 !    8.8   0.0   0.00059       1.1     145     218 ..     255     321 ..     238     327 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.038
         SGL   9 eeegaLlwvDilgqrihrldpatgketvldtpesvGaiaprkdgrlvvasksglalldlasgeletladeeedekpllrfNDgvvdpdGrlwfGtmgde 107
                  +                                                                                                 
  EFC38321.1  78 HR------------------------------------------------------------------------------------------------- 79 
                 33................................................................................................. PP

         SGL 108 eakgeevgalyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwgggk 206
                                                                                                       +Gnv+   +g+++
  EFC38321.1  80 --------------------------------------------------------------------------------------NGNVYFSDLGNNR 92 
                 ......................................................................................5555555555555 PP

         SGL 207 vvrfdpdG 214
                 ++++d++G
  EFC38321.1  93 IRKIDNNG 100
                 55555555 PP

  == domain 2  score: 27.3 bits;  conditional E-value: 1.4e-09
         SGL  94 dpdGrlwfGtmgdeeakgeev.........galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge 183
                 +++G+++f ++g+++ ++ ++         ++ y l +dg l  + + l+ p G+++s+dg+ lY+aD  ++ i ++++++++ +    + + +++ ge
  EFC38321.1  78 HRNGNVYFSDLGNNRIRKIDNngiistivgCGDYGLVGDGNL-AINSFLNSPRGICLSNDGNYLYIADRDNHAIRKVSLNDDDDNGLIETIVGNGSSGE 175
                 678999999999999999888766655554333444444222.2344478899**************************99999777778787888887 PP

         SGL 184 ............gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                             + p G+a+ ++++++   +++++++++d++Gkl +
  EFC38321.1 176 sengslalnsqiNCPYGIAISKDDELYFSEFSNHTIRKIDKNGKLWK 222
                 999*****998877******************************976 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00059
         SGL 145 gktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 ++ lY+aD  +++i ++d+  ++g l n  v+ +l+     p G +v+ ++ +++A  +++++  +d + ++i+
  EFC38321.1 255 NNNLYIADRDNNSIRKIDL--KTG-LINTAVVKELNS----PLGCFVTINNILYIADTDNHQIKMIDLNNEIIT 321
                 5568888888888888888..566.677777744443....558888888888888888888888888888775 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       2.4   4.4e+03      44      76 ..      59      91 ..      44      97 .. 0.58
   2 !   11.3   0.0   0.00016      0.29      51      78 ..     123     150 ..     114     158 .. 0.83
   3 ?    1.5   0.0      0.19   3.5e+02      51      82 ..     185     215 ..     176     219 .. 0.78
   4 ?   -3.5   0.0         7   1.2e+04      66      78 ..     256     268 ..     247     272 .. 0.70
   5 ?    1.3   0.0      0.22   3.9e+02      48      81 ..     281     313 ..     277     318 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.4
  Arylesterase 44 sevkvvasglssanGInidadkkyiyvadilre 76
                  +++k   + ++ +  + ++  +  +y +d+ ++
    EFC38321.1 59 DNIKATQATINKPVCVIVNHRNGNVYFSDLGNN 91
                  455555555555555555555555555555444 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00016
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   s l+s+ GI ++ d  y+y+ad  ++ i
    EFC38321.1 123 SFLNSPRGICLSNDGNYLYIADRDNHAI 150
                   45789*****************988887 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.19
  Arylesterase  51 sglssanGInidadkkyiyvadilresihvmk 82 
                   s+++ + GI i+ d+  +y ++  ++ i  ++
    EFC38321.1 185 SQINCPYGIAISKDDE-LYFSEFSNHTIRKID 215
                   678899******9986.688888888876655 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 7
  Arylesterase  66 kyiyvadilresi 78 
                     +y+ad  ++si
    EFC38321.1 256 NNLYIADRDNNSI 268
                   4578888777776 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.22
  Arylesterase  48 vvasglssanGInidadkkyiyvadilresihvm 81 
                    v++ l+s+ G  +   + ++y+ad  +++i ++
    EFC38321.1 281 AVVKELNSPLGCFVTI-NNILYIADTDNHQIKMI 313
                   5677788888877765.579******99999665 PP

>> DUF5074  Domain of unknown function (DUF5074)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.0   0.00017       0.3       2      64 ..      76     146 ..      75     166 .. 0.86
   2 ?    4.0   0.1     0.028        50       5      64 ..     216     306 ..     193     332 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00017
     DUF5074   2 vqskDGnvWaa..sgtkLvkinpktlevktvelpe......lsiesswyawtptslcasttenaLYfiggs 64 
                 v  + Gnv+ +   ++++ ki+ + + ++ v + +       + + +++  +p+ +c s   n+LY+++ +
  EFC38321.1  76 VNHRNGNVYFSdlGNNRIRKIDNNGIISTIVGCGDyglvgdGNLAINSFLNSPRGICLSNDGNYLYIADRD 146
                 77889******9999************999999887655456788899999****************9877 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.028
     DUF5074   5 kDGnvWaa..............................sgtkLvkinpktlevktvelpelsiesswyawtptsl.casttenaLYfiggs 64 
                 k G++W +                              ++++L+  +  + ++ +++l+   i+++     ++ l c  t +n+LY+++++
  EFC38321.1 216 KNGKLWKVagidgkngnneydhhafnnllnypayicfdNNNNLYIADRDNNSIRKIDLKTGLINTAVVKELNSPLgCFVTINNILYIADTD 306
                 5566665566666666666666666677777777777777777777777777777777775555555444444333555777888887776 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.48   8.7e+02     143     169 ..      69      95 ..      53     103 .. 0.73
   2 !   10.2   0.0   0.00018      0.33     290     323 ..     125     158 ..     118     176 .. 0.78
   3 ?    2.9   0.0      0.03        54     244     270 ..     245     270 ..     203     323 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.48
                 TTEEEEEE-TTSSEEEEEETTTTEEEE CS
   Lactonase 143 phaHsvvldpdgkfllvpDLGtDrvrv 169
                  ++ +v++   +  +++ DLG  r+r 
  EFC38321.1  69 NKPVCVIVNHRNGNVYFSDLGNNRIRK 95 
                 555567777778888899999888875 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00018
                 SS.--EEEE-TTSSEEEEEETTTTEEEEEEEETT CS
   Lactonase 290 gkfPRdfaldpsgklllvanqksdnvtvferdae 323
                  + PR + l+++g++l++a+++ + +  ++ + +
  EFC38321.1 125 LNSPRGICLSNDGNYLYIADRDNHAIRKVSLNDD 158
                 57899***************99999988887654 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.03
                 --EEEEEE-TTSSEEEEEETSSTEEEE CS
   Lactonase 244 nsaaeIrlspdgkflyvSnRgadsiav 270
                 n +a I    ++++ly+++R ++si  
  EFC38321.1 245 NYPAYICFD-NNNNLYIADRDNNSIRK 270
                 566777776.77889999999999864 PP

>> Reg_prop  Two component regulator propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.47   8.4e+02       7      21 ..      72      86 ..      68      89 .. 0.77
   2 ?   -1.0   0.1       1.9   3.5e+03       2      17 ..      88     101 ..      87     102 .. 0.77
   3 ?    1.4   0.0      0.31   5.6e+02       8      21 ..     129     143 ..     123     146 .. 0.79
   4 ?   -1.7   0.0       3.2   5.8e+03       8      20 ..     191     203 ..     186     206 .. 0.77
   5 ?    3.4   0.1     0.068   1.2e+02      12      19 ..     213     221 ..     202     221 .. 0.74
   6 !    6.2   0.0    0.0084        15       9      22 ..     249     262 ..     242     264 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.47
                EEEEEE-TTSCEEEE CS
    Reg_prop  7 vtaileDsdGrlWvG 21
                v  i+  ++G+++++
  EFC38321.1 72 VCVIVNHRNGNVYFS 86
                55678899*****97 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.9
                 BSSSCEEEEEE-TTSC CS
    Reg_prop   2 lpsnnvtaileDsdGr 17 
                 l +n+++ i  D++G 
  EFC38321.1  88 LGNNRIRKI--DNNGI 101
                 788899888..88986 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.31
                 EEEEE-TTS.CEEEE CS
    Reg_prop   8 taileDsdG.rlWvG 21 
                 + i+  +dG +l+++
  EFC38321.1 129 RGICLSNDGnYLYIA 143
                 5799999**999987 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 3.2
                 EEEEE-TTSCEEE CS
    Reg_prop   8 taileDsdGrlWv 20 
                 + i+  +d  l++
  EFC38321.1 191 YGIAISKDDELYF 203
                 6788888999988 PP

  == domain 5  score: 3.4 bits;  conditional E-value: 0.068
                 E.-TTSCEE CS
    Reg_prop  12 e.DsdGrlW 19 
                 + D++G+lW
  EFC38321.1 213 KiDKNGKLW 221
                 34******* PP

  == domain 6  score: 6.2 bits;  conditional E-value: 0.0084
                 EEEE-TTSCEEEEE CS
    Reg_prop   9 aileDsdGrlWvGt 22 
                  i+ D++++l+++ 
  EFC38321.1 249 YICFDNNNNLYIAD 262
                 5999********85 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       3.9   6.9e+03       6      17 ..      22      32 ..      14      42 .. 0.68
   2 ?    0.2   0.0      0.45   8.1e+02       5      17 ..      76      88 ..      73      95 .. 0.85
   3 ?    5.5   0.0      0.01        18      56      83 ..     125     152 ..     119     158 .. 0.82
   4 ?    4.5   0.0     0.021        37      54      83 ..     185     213 ..     177     218 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3.9
   Str_synth  6 deetgvlyftds 17
                ++  +++y+ d+
  EFC38321.1 22 NQC-DEVYIADT 32
                333.77777775 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.45
   Str_synth  5 vdeetgvlyftds 17
                v++++g +yf+d 
  EFC38321.1 76 VNHRNGNVYFSDL 88
                88999******96 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.01
   Str_synth  56 LyfanGialsedgsfvlvcetamkrisr 83 
                 L  + Gi ls+dg+++ +++   + i +
  EFC38321.1 125 LNSPRGICLSNDGNYLYIADRDNHAIRK 152
                 78899***********999887777666 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.021
   Str_synth  54 dkLyfanGialsedgsfvlvcetamkrisr 83 
                 +++  + Gia+s+d++ + ++e++ + i +
  EFC38321.1 185 SQINCPYGIAISKDDE-LYFSEFSNHTIRK 213
                 5667778888888865.5677777766554 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.046        82      76     101 ..      78     103 ..      74     143 .. 0.78
   2 ?    6.2   0.0     0.005       8.9      72     102 ..     192     222 ..     130     234 .. 0.70
   3 ?    0.9   0.0      0.19   3.5e+02      73     101 ..     250     279 ..     249     289 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.046
  Phytase-like  76 apdgtfwvssEggpfilefdadGkll 101
                    ++g++++s+ g+++i+++d +G + 
    EFC38321.1  78 HRNGNVYFSDLGNNRIRKIDNNGIIS 103
                   789******************99775 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.005
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkllr 102
                   gia+++d+++++s+  ++ i+++d++Gkl +
    EFC38321.1 192 GIAISKDDELYFSEFSNHTIRKIDKNGKLWK 222
                   9***********99999**********9855 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.19
  Phytase-like  73 iavapdgtfwvssEggpfilefdad.Gkll 101
                   i +++++++++++  +++i+++d++ G + 
    EFC38321.1 250 ICFDNNNNLYIADRDNNSIRKIDLKtGLIN 279
                   567889999999999999999999867664 PP

>> TRL  TRL-like protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0      0.02        36      32      54 ..      84     106 ..      78     109 .. 0.85
   2 ?    6.5   0.0    0.0057        10      31      60 ..     201     230 ..     196     233 .. 0.90
   3 ?    0.9   0.2      0.32   5.7e+02      28      54 ..     297     323 ..     294     325 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.02
         TRL  32 glvstGdaSieaaaknggItkia 54 
                 ++  +G++ i+++ +ng I++i 
  EFC38321.1  84 YFSDLGNNRIRKIDNNGIISTIV 106
                 44556***************995 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0057
         TRL  31 LglvstGdaSieaaaknggItkiasvDyet 60 
                 L++  + +  i+++ kng+  k+a +D ++
  EFC38321.1 201 LYFSEFSNHTIRKIDKNGKLWKVAGIDGKN 230
                 789999********************9776 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.32
         TRL  28 ksiLglvstGdaSieaaaknggItkia 54 
                 ++iL++  t +  i+ +  n++I +i+
  EFC38321.1 297 NNILYIADTDNHQIKMIDLNNEIITIT 323
                 689999999999999999999999986 PP

>> LVIVD  LVIVD repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.58     1e+03      14      21 ..      27      34 ..      27      36 .. 0.86
   2 ?   -2.3   0.1       1.6   2.8e+03      11      22 ..     109     118 ..     103     121 .. 0.77
   3 ?   12.0   0.1   5.3e-05     0.096      11      21 ..     137     147 ..     132     149 .. 0.91
   4 ?    2.4   0.2     0.056     1e+02      13      21 ..     257     265 ..     247     267 .. 0.81
   5 ?    1.7   0.0      0.09   1.6e+02      14      21 ..     300     307 ..     296     314 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.58
       LVIVD 14 aYvAdqdn 21
                +Y+Ad +n
  EFC38321.1 27 VYIADTEN 34
                6****988 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.6
       LVIVD  11 GnYaYvAdqdng 22 
                 G+Y  v+d+   
  EFC38321.1 109 GDYGLVGDG--N 118
                 999999976..3 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 5.3e-05
       LVIVD  11 GnYaYvAdqdn 21 
                 GnY+Y+Ad+dn
  EFC38321.1 137 GNYLYIADRDN 147
                 9*********9 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.056
       LVIVD  13 YaYvAdqdn 21 
                  +Y+Ad+dn
  EFC38321.1 257 NLYIADRDN 265
                 579999988 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.09
       LVIVD  14 aYvAdqdn 21 
                 +Y+Ad dn
  EFC38321.1 300 LYIADTDN 307
                 8*****99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 1994.00
//
Query:       EFC38322.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.011   15.2   0.1      0.015   14.7   0.1    1.3  1  DUF1571   Protein of unknown function (DUF1571)
       0.63    8.0   8.8       0.78    7.8   8.8    1.1  1  AF-4      AF-4 proto-oncoprotein


Domain annotation for each model (and alignments):
>> DUF1571  Protein of unknown function (DUF1571)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.1   1.7e-06     0.015     137     207 ..     102     169 ..      65     170 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.7e-06
     DUF1571 137 ehpskeeqvefskaelllDeelklpirveaydwPaaeddseelvEeyeyadlklnvgltdadFdpanpdyk 207
                 +  +++   +++++++l+ ++++l+ + + y   + +++++++v +++y d ++++++t++dF+p+ p y+
  EFC38322.1 102 KNLKNNSLCKAKIVKILMSNQSDLISQTNPY---HITQENQRIVLHIQYIDTSVKEEITNQDFEPQVPTYT 169
                 4444455578999******************...55999999***************************97 PP

>> AF-4  AF-4 proto-oncoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   8.8   8.7e-05      0.78     480     526 ..       3      51 ..       1      75 [. 0.70

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 8.7e-05
        AF-4 480 SSSeSDSesEssssdseanepprtatpepeppa.tnkWqL.dnwlnkvn 526
                 SSS+ +S sEss++ se++  + ++ +   + +  n+ q+ + w++k +
  EFC38322.1   3 SSSDNNSSSESSTTTSEIESSSSSSLSTTTSTTtDNNKQIyRTWIKKQQ 51 
                 6777778888888889888888777665444442555554278999877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1491  (0.0831614); expected 358.6 (0.02)
Passed bias filter:                      591  (0.0329634); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 969.47
//
Query:       EFC38323.1  [L=1385]
Description: DEXH-box helicase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.9e-28   98.6   0.0    7.8e-28   97.2   0.0    1.6  2  SNF2_N      SNF2 family N-terminal domain
    1.4e-14   53.9  29.8    8.9e-11   41.7   4.2    2.9  3  zf-GRF      GRF zinc finger
    1.4e-09   38.3   0.4    2.5e-08   34.2   0.0    2.9  3  Helicase_C  Helicase conserved C-terminal domain
    5.4e-06   26.5   0.0    5.4e-06   26.5   0.0    4.1  3  ResIII      Type III restriction enzyme, res subunit
  ------ inclusion threshold ------
      0.021   14.9   0.4      0.087   12.9   0.0    2.1  2  TetR_C_27   Tetracyclin repressor-like, C-terminal domain


Domain annotation for each model (and alignments):
>> SNF2_N  SNF2 family N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0      0.83     3e+03     136     160 ..     217     241 ..     204     253 .. 0.66
   2 !   97.2   0.0   2.2e-31   7.8e-28      59     320 ..     356     619 ..     343     645 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.83
                 ----------------EEEE-HHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 136 kkkntkvapklladydvvittYdvl 160
                 +k +++++    a+yd+v++t+ +l
  EFC38323.1 217 QKDRHETLVFNNANYDCVLVTFPKL 241
                 2222333444457999**9999876 PP

  == domain 2  score: 97.2 bits;  conditional E-value: 2.2e-31
                 EE---TTS--HHHHHHHHH...HHTTTS---.......S-EEEE--HHHHHHHHHHHHHH-TTS-EEE--SSHHHH-----------------EEEE-H CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N  59 iLaDemGLGKTvqvlalilaqrakeekdkekkrkdtlagptLivvPaslldqWeneierhvsssalrvlvyggqkkmkkkntkvapklladydvvittY 157
                 +L DemG+GKT+q l+ +    + ++++           p Li++P+sl ++W +eie++   s+     ++ + +m+k +     k+  d  + i++Y
  EFC38323.1 356 LLGDEMGVGKTLQGLSTMY---YFKQDW-----------PLLIICPSSLKHNWGKEIEEWFITSER----GHTDITMEKIKIISHGKQIPDNYINIVSY 436
                 89*****************...755555...........59*******************999875....55555688888889999************ PP

                 HHHHHHT.............TTS-S-S-SEEEES-GGGT--T.TSHHHHHHHH---S-EEE.E-S--SSS-HHHHHHHHHHH-TTTT--.HHHHHHHTH CS
                 xxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxx RF
      SNF2_N 158 dvlsreaelq.......kkrsvlkqvewkrvvlDEghtlkns.tskaaeavskLstsnrwi.ltGTPiqnsledlygLlkfLreepfge.kqtfdkllq 246
                  + ++  e q            l+ ++ +++++DE h lkns t++ + +v  L++ +r++ +tGTP      ++y+ l++L  ++f+  +  f  ++ 
  EFC38323.1 437 TMAANMLESQpcnndggGGGAILNGIKFNCIICDESHYLKNSsTKRSSHIVPFLKQAKRLVmITGTPALSRPVEVYPQLNLLLDDKFTFtRSAFTYRYC 535
                 ****999999999999988899********************78888888888**99997538*************************85557777777 PP

                 HHHH......HHHHHHHHHHHTT-ST.TEE---GGGT--S---EEEEEEEEE--HHHHHHHH...................... CS
                 xxxx......xxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxx RF
      SNF2_N 247 rpie......aqaekgrsrLlqllqr.lmlrrakkdveknlPpkteeiiflklskverksYn...rllevlrkkalakllkrse 320
                 +  e       +   ++ +L+ ll+r +m+rr+k+ v  +lP+k+ + ++l+ ++ ++k  +   ++++ +++k+   ++++++
  EFC38323.1 536 DAKEtqfgldDKGSSNVLELNYLLSRtVMIRRRKETVLSELPEKQRQRVLLSVKPSDLKQLEfsaERMKRAIEKMKTAITSEEH 619
                 76668899888888899999999986379********99********9999998876665550003333333333333333222 PP

>> zf-GRF  GRF zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.7   4.2   2.5e-14   8.9e-11       2      44 ..      11      54 ..      10      55 .. 0.90
   2 !   25.9   8.7   2.1e-09   7.6e-06       1      44 [.     124     165 ..     124     166 .. 0.92
   3 ?   -4.0   1.6       4.8   1.7e+04       9      24 ..     998    1013 ..     996    1015 .. 0.83

  Alignments for each domain:
  == domain 1  score: 41.7 bits;  conditional E-value: 2.5e-14
      zf-GRF  2 lCkcgrlavlltvrktgpNkGRkFYkCpkgke..kqCgFFkWade 44
                +Ckcg la+l++  k+g N GR++++C+   +  + C+FFkW d+
  EFC38323.1 11 QCKCGALAQLRVT-KKGDNMGREYWACARNFGdrERCNFFKWSDN 54
                8***********9.5************986655699*******97 PP

  == domain 2  score: 25.9 bits;  conditional E-value: 2.1e-09
      zf-GRF   1 plCk.cgrlavlltvrktgpNkGRkFYkCpkgkekqCgFFkWade 44 
                 plC+ ++  +v++ v k+g NkG+ F++C+   +   ++F+W+ e
  EFC38323.1 124 PLCPkHQITCVQKRVVKEGNNKGKLFWCCNIEHG---CYFEWCKE 165
                 69*98889999999999***************98...8*****76 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 4.8
      zf-GRF    9 avlltvrktgpNkGRk 24  
                  +++ t+++t  N+++k
  EFC38323.1  998 SFRDTNNNTKNNNTKK 1013
                  6778999999999987 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.22     8e+02       5      29 ..     209     233 ..     204     265 .. 0.70
   2 ?   -3.4   0.0       3.5   1.3e+04      46      63 ..     572     589 ..     555     596 .. 0.72
   3 !   34.2   0.0   6.9e-12   2.5e-08      32     111 .]     695     777 ..     645     777 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.22
                 HHHHHHHHTTTTSEEEEEESSHHHH CS
  Helicase_C   5 allellkleeeggkilifvntidrl 29 
                 +l + +k++++++++l+f n   ++
  EFC38323.1 209 ILQQAMKQQKDRHETLVFNNANYDC 233
                 4455567788888888888776655 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 3.5
                 ESTTSTHHHHHHHHHHHH CS
  Helicase_C  46 lhgelpqnereeileqfn 63 
                 + +elp ++r+++l + +
  EFC38323.1 572 VLSELPEKQRQRVLLSVK 589
                 557889999998887765 PP

  == domain 3  score: 34.2 bits;  conditional E-value: 6.9e-12
                 HHHHHHHT..TSTEEEESTTSTHHHHHHHHHHHH.TTSSS.EEEESGGGTSSSTSTTESEEEESSSSSSHHHHHHHHTTSSSTT CS
  Helicase_C  32 vklllekk..gikvavlhgelpqnereeileqfn.kgesd.vLiatdvaerGidipkvnlVinfdlprnvtsyiqriGRtgRag 111
                  k l++ k  g  +++++g++ +n r+  ++ f+ +g+++  +++ ++a+ G +++ +++V + +l ++++++ q+ +R++R+g
  EFC38323.1 695 SKDLQK-KmrGDYYIRIDGSTDSNRRQNLVNTFRtNGHCRvAILSIKAAGVGYTMTPCSTVLFAELYWTPSDLRQAEDRVHRMG 777
                 233322.23688899*******************99****99****************************************86 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.5   0.0   1.5e-09   5.4e-06       4     170 ..     337     504 ..     305     505 .. 0.73
   2 !    5.5   0.6    0.0044        16      10      97 ..     605     712 ..     596     734 .. 0.66
   3 ?   -4.1   6.2       3.8   1.4e+04      73     122 ..     998    1062 ..     979    1097 .. 0.65

  Alignments for each domain:
  == domain 1  score: 26.5 bits;  conditional E-value: 1.5e-09
                 E-HHHHHHHHHHT......TTSEEEEEESTTSTHHHHHHHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG...........GEEEESSS-B- CS
      ResIII   4 lreyQeeaienlleklkskrdkrglikmaTGtGKTlvaaklierllkkgkeekflflvprkslleqtleefkkflseayke.......igkkvsgdkkk 95 
                 lr+ Q++ i   +     kr+ r+l+  + G+GKTl  +++++++++  +    l+++p  sl   + +e+++++ +           + k++s     
  EFC38323.1 337 LRPFQKQGISFAV-----KREGRVLLGDEMGVGKTLQGLSTMYYFKQD-W--PLLIICP-SSLKHNWGKEIEEWFITSERGhtditmeKIKIIS----- 421
                 4444444444443.....8999*********************99996.3..4666666.68*********99999987664344333333344..... PP

                 -.......-SEEEEEHHHHHHTH..............HHHTTT-S......EEEEETGGGTTS...TTTHHHHHT---.SEEEEEESS-S CS
      ResIII  96 akekdstnkkilvttiqsldadseee......eeeseellrdrfd......viiiDEaHrlgak..kswreilekfke.avllglTATpe 170
                  + k++ ++ i ++++ ++ + +e++                  +      +ii+DE+H l+ +  k   +i+  +k+ + l+ +T+Tp 
  EFC38323.1 422 -HGKQIPDNYINIVSYTMAANMLESQpcnndgGGGGAI------LngikfnCIICDESHYLKNSstKRSSHIVPFLKQaKRLVMITGTPA 504
                 .5555569*************99666555444333333......1445555***********9744466667777655266777899995 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0044
                 HHHHHHT.............TTSEEEEEESTTSTHHHHH..HHHHHHH-S.....-EEEEESSHHHHHHHH.......HHGGGGTGG......GEEEES CS
      ResIII  10 eaienlleklks.......krdkrglikmaTGtGKTlva..aklierllkkgkeekflflvprkslleqtl.......eefkkflseayke..igkkvs 90 
                 +aie+++ +++s        +++  ++ m T tGK  +    + i+ + ++ +  kfl+++  k++++  +        +f +++ +++k+   +kk++
  EFC38323.1 605 RAIEKMKTAITSeehnqsnFDKNSEIFRMYTMTGKAKLPavKEYIQDMIENTGDLKFLVFAYHKEVMDGIEecvalelAKFYNLKGQKKKSkdLQKKMR 703
                 45666665555566665545555889*********99873346788888888877****************5555444444444444433344555566 PP

                 SS-B--... CS
      ResIII  91 gdkkka..k 97 
                 gd +++   
  EFC38323.1 704 GDYYIRidG 712
                 655555542 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 3.8
                  HGGGGTGG....GEEEESSS-B--..................-SEEEEEHHHHHHTH.............. CS
      ResIII   73 efkkflseaykeigkkvsgdkkka...........kekdstnkkilvttiqsldadseee..........e 122 
                   f+++ ++++++++kk       +            ++d+++ +i++ t ++ +++++++          +
  EFC38323.1  998 SFRDTNNNTKNNNTKKR------HlddeeeeddmkVNSDDDDDDITFGTPKKNNSSITQKtspffsklksS 1062
                  34444444433322222......122233356777789999**********99999966666666654440 PP

>> TetR_C_27  Tetracyclin repressor-like, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1      0.61   2.2e+03       3      27 ..     246     270 ..     245     272 .. 0.91
   2 ?   12.9   0.0   2.4e-05     0.087      16      51 ..     620     655 ..     606     659 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.61
                 HHHHHHHHHHHHHHHHHHHH-HHHH CS
   TetR_C_27   3 erLrewlaalfeakrrkarddpelF 27 
                 ++L + l++lf+ k +k+ d ++lF
  EFC38323.1 246 DKLLRSLKELFDNKITKLNDLEYLF 270
                 689999**************99999 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 2.4e-05
                 HHHHHHH-HHHHHHHHHHHHH-HHHHHHHHHHHHHH CS
   TetR_C_27  16 krrkarddpelFatyvvlieeelevvekhieeleeq 51 
                  ++++ ++ e+F++y+++++++l +v+++i++++e 
  EFC38323.1 620 NQSNFDKNSEIFRMYTMTGKAKLPAVKEYIQDMIEN 655
                 578899**************************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1755  (0.0978861); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.19u 0.39s 00:00:01.58 Elapsed: 00:00:00.56
# Mc/sec: 7415.93
//
Query:       EFC38324.1  [L=996]
Description: rasGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-46  157.2  10.4    3.3e-45  154.4   2.8    3.5  4  RasGEF    RasGEF domain
    1.9e-14   53.8   0.4    1.9e-14   53.8   0.4    3.9  3  RasGEF_N  RasGEF N-terminal motif
     0.0045   16.4   0.0     0.0084   15.6   0.0    1.3  1  TPALS     TIR- and PNP-associating SLOG family


Domain annotation for each model (and alignments):
>> RasGEF  RasGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.52   3.1e+03      67      88 ..     180     201 ..     142     256 .. 0.77
   2 ?   -2.9   0.0       1.1   6.7e+03      91     104 ..     475     488 ..     439     538 .. 0.53
   3 !    5.9   0.0    0.0023        14     100     157 ..     658     741 ..     623     747 .. 0.69
   4 !  154.4   2.8   5.5e-49   3.3e-45       1     176 [.     749     932 ..     749     933 .. 0.95

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.52
      RasGEF  67 iekfikiakecrklnNfnslma 88 
                 +++ ++   ++++lnN+ns m 
  EFC38324.1 180 FKQALRFKGQLEELNNLNSQMN 201
                 5555566666777777777664 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.1
      RasGEF  91 saLqsspvsrLkkt 104
                  aL++ ++++ +k 
  EFC38324.1 475 YALCKEAIKKSEKL 488
                 33333333333222 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0023
      RasGEF 100 rLkktweavskkslktleelee...lmspennfknyrealkssa........................sskpciPflglyltdlt 157
                 +L+k+ ++++ + ++++++l++   +  ++nn  n+ + +++                           ++p+iP   ++ +dl 
  EFC38324.1 658 KLNKSRKKIN-EIITQMSKLSNintFSFNNNNNNNMNNNMNNNMnmnnsgigmgggggisrnvnssdkIPEPIIPWNKIFASDLC 741
                 5666667776.4444444444422144444455555555555556777778888888888888888889999****999999994 PP

  == domain 4  score: 154.4 bits;  conditional E-value: 5.5e-49
      RasGEF   1 elAeqltlieaelfskikpeellgsawsked...rspnveaviarfnrlsnwvaseilseeslkkRakviekfikiakecrklnNfnslmailsaLqss 96 
                 e+A+ql+l+e++++ +ik+eell++aw k +   rspnv +++++f+++s wvas+i++ ++   R  + + +i +++++rk+nNfn+l ails++++ 
  EFC38324.1 749 EMARQLCLYEFDMYYSIKSEELLNQAWRKPKlkhRSPNVLNMMNFFDNISMWVASLICRGQTTYARKHTYKMLIIVCDQLRKMNNFNTLRAILSGFENG 847
                 79***************************9987666*************************************************************** PP

      RasGEF  97 pvsrLkktweavskkslktleeleelmspennfknyrealkssasskpciPflglyltdltfieegnpdtl......egk.iNfeKr 176
                 +v+rLk t +++ +ks++t + l++lms+enn+k+y+e lk+s  s p+iP+lg++l+dl +iee+++d++        + iN+ Kr
  EFC38324.1 848 AVKRLKDTRSELGQKSKDTENLLKQLMSEENNYKKYKEVLKTS--SFPAIPYLGVHLQDLQYIEENHNDYVkntnrnGVElINWIKR 932
                 ******************************************9..8999*****************999998888874445999886 PP

>> RasGEF_N  RasGEF N-terminal motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -7.6   7.2         3   1.8e+04      90      90 ..     346     346 ..     280     405 .. 0.52
   2 !   53.8   0.4   3.1e-18   1.9e-14       2     105 .]     558     648 ..     557     648 .. 0.88
   3 ?   -1.2   0.2       0.4   2.4e+03      47      64 ..     680     699 ..     668     725 .. 0.66

  Alignments for each domain:
  == domain 1  score: -7.6 bits;  conditional E-value: 3
    RasGEF_N  90 y 90 
                 +
  EFC38324.1 346 K 346
                 1 PP

  == domain 2  score: 53.8 bits;  conditional E-value: 3.1e-18
    RasGEF_N   2 vkagtlekLierLtskrlldddfletFLltyrsFttpaeLlekLieryeinppnnlesdesnswnsksssnirlrvlsvlkewvenhyydfsddkalls 100
                  +ag+l+++ierLt +  +d +f+ +FL+ty    +p+ +l+kL++r++++++ +   +          + i+  v++vl  w+enh+++f+++  +l+
  EFC38324.1 558 FQAGSLNRIIERLTIP-TQDQSFIDVFLHTYMAIASPELVLGKLFQRFKVPSTFTPDVK----------NGIQSAVIRVLLIWIENHFHHFTNN--MLQ 643
                 579*************.77779**************************65555554444..........67***********************..799 PP

    RasGEF_N 101 klekf 105
                 kl+ f
  EFC38324.1 644 KLQSF 648
                 98876 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.4
    RasGEF_N  47 eryeinppnnlesdes..ns 64 
                 +++ +n++nn++ +    n+
  EFC38324.1 680 NTFSFNNNNNNNMNNNmnNN 699
                 55666766666666221222 PP

>> TPALS  TIR- and PNP-associating SLOG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   1.4e-06    0.0084      87     181 ..     653     754 ..     624     771 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.4e-06
       TPALS  87 vshhkteeqipeerreLwdrLraselvkiesieddn..mtgkrieaqarvgdalialGGgkGVsylAnkyhkagkPviPLd....lplgaeseDGe.Ga 178
                 v  h+  ++  ++ +e+++++++   +++ s +++n     ++++  +++ +  i +GGg G+s   n   k  +P+iP +      l+ e+ DGe  a
  EFC38324.1 653 VLIHAKLNKSRKKINEIITQMSKLSNINTFSFNNNNnnNMNNNMNNNMNMNNSGIGMGGGGGISRNVNSSDKIPEPIIPWNkifaSDLCIEDIDGEeMA 751
                 444555566666666777777777777776666655222347889**********************************87332247888888887566 PP

       TPALS 179 rrL 181
                 r+L
  EFC38324.1 752 RQL 754
                 665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (996 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1963  (0.109487); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.80u 0.33s 00:00:01.13 Elapsed: 00:00:00.50
# Mc/sec: 5991.82
//
Query:       EFC38325.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.16   10.5  23.4       0.18   10.3  23.4    1.1  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3  23.4     1e-05      0.18     216     377 ..      18     181 ..       2     294 .. 0.56

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 1e-05
    Macoilin 216 aeeqlaaakelvevdpvalsknnhslnkkdsslklpeleyrekkksakssrsdskkkhehn.......esvdsklqekeymenkskskrlsksessgse 307
                 ++ ++++++ +v    +++ knn  l+k++  ++  + + + ++  + s+ ++       +       +++++ ++ ++  +++ ++k+  ++++++++
  EFC38325.1  18 SSAAASSTTSIVASMNSMMMKNNLLLTKNNLIHHHHQSKASFSSLLNVSHYES-------SspsdnisSNIQTTTTTQKAPSKNCTTKKYIEDTKPSKA 109
                 22222333333322233333333333332222211111111111112222222.......122222223333333333333333444444455566666 PP

    Macoilin 308 sellveesvkskssssssssn..knskkasagsagssnssskkhsessksvtsssssknskkqklpaGkssa 377
                 s+++ +++++ +ss+ssss++   n+k +++ +  + nsss +  ++s+s  +s ++k+ kkqk +  ks +
  EFC38325.1 110 SSTNINGHSSTSSSTSSSSQKivINTKLNTSVKNFIRNSSSSSSASASSSLIQSENDKKIKKQKSTDLKSLS 181
                 666666665555544444443336777777777778999999999999999999999999999987555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2465  (0.137487); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.36s 00:00:01.08 Elapsed: 00:00:00.58
# Mc/sec: 1759.43
//
Query:       EFC38326.1  [L=804]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.7e-16   59.0  19.8      8e-12   45.2   0.3    6.3  7  PPR_2         PPR repeat family
    4.5e-13   48.5  11.1    2.9e-05   24.0   0.0    6.2  6  PPR           PPR repeat
    7.8e-06   25.9  25.5    1.2e-05   25.3   0.3    7.1  8  PPR_3         Pentatricopeptide repeat domain
    7.4e-05   22.4   0.4    7.4e-05   22.4   0.4    5.8  8  PPR_1         PPR repeat
    0.00021   20.7   2.1        0.3   10.4   0.0    3.6  3  PPR_long      Pentacotripeptide-repeat region of PRORP
  ------ inclusion threshold ------
        1.5    9.0   6.2       0.75   10.0   0.3    2.8  3  DAG_kinase_N  Diacylglycerol kinase N-terminus


Domain annotation for each model (and alignments):
>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.1   3.4e+03       6      28 ..     176     198 ..     175     203 .. 0.71
   2 ?   -0.6   0.1      0.53   1.6e+03       5      23 ..     257     275 ..     256     276 .. 0.89
   3 ?   -0.7   0.1      0.57   1.7e+03       4      13 ..     333     342 ..     328     354 .. 0.84
   4 !   45.2   0.3   2.7e-15     8e-12       2      48 ..     369     415 ..     368     416 .. 0.96
   5 !   16.6   0.1   2.3e-06    0.0068       6      45 ..     478     517 ..     476     521 .. 0.90
   6 !    5.7   0.1    0.0058        17      24      48 ..     658     682 ..     653     684 .. 0.87
   7 ?    4.1   0.1     0.018        53       2      46 ..     671     719 ..     670     721 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.1
       PPR_2   6 yNtlIsglckkgkveeAfklfne 28 
                 y +l+  +++ gk + +  lfn 
  EFC38326.1 176 YHCLLVIYAHTGKQDLCENLFNT 198
                 66777778888887777777774 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.53
       PPR_2   5 tyNtlIsglckkgkveeAf 23 
                 +y ++ +++   g++e+A+
  EFC38326.1 257 IYQSMVNAYSIMGNFEKAL 275
                 5889************996 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.57
       PPR_2   4 vtyNtlIsgl 13 
                 +t NtlI+ +
  EFC38326.1 333 ITLNTLINIY 342
                 6889999988 PP

  == domain 4  score: 45.2 bits;  conditional E-value: 2.7e-15
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikgl 48 
                 + +t++t+I +lc + ++++A+++fn Mk+ +++P+ +Ty +l+ g+
  EFC38326.1 369 NAITFTTVIRHLCMNDHFDSALDMFNRMKELNIKPTRVTYKVLLEGM 415
                 889*****************************************996 PP

  == domain 5  score: 16.6 bits;  conditional E-value: 2.3e-06
       PPR_2   6 yNtlIsglckkgkveeAfklfneMkkrglePnsyTysili 45 
                 y +l   +ck ++++ A  l  eM +rg++P+  T++  i
  EFC38326.1 478 YEHLVLFYCKINNFSRARFLIYEMLERGVTPTMRTFTHFI 517
                 6667778*****************************9877 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.0058
       PPR_2  24 klfneMkkrglePnsyTysilikgl 48 
                 +++ eMk+++l  +  +++  + +l
  EFC38326.1 658 QFYLEMKRNNLILDIRSFNLYLEAL 682
                 7899***************988877 PP

  == domain 7  score: 4.1 bits;  conditional E-value: 0.018
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkr....glePnsyTysilik 46 
                 d+ ++N ++ +l++ + +++ +k fn  +      ++ P+  T  ili+
  EFC38326.1 671 DIRSFNLYLEALLNTEGSNSMWKYFNTCQTSteiiKINPDIDTLHILIR 719
                 6779*********************988775323334777777777776 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.4   4.2e+03       3      24 ..     176     197 ..     175     202 .. 0.73
   2 !    9.9   0.2    0.0003      0.89       2      20 ..     257     275 ..     256     277 .. 0.92
   3 !    6.8   0.0    0.0029       8.8       1      26 [.     333     358 ..     333     361 .. 0.84
   4 !   24.0   0.0   9.8e-09   2.9e-05       1      31 []     371     401 ..     371     401 .. 0.95
   5 !    9.1   0.1   0.00057       1.7      10      31 .]     485     506 ..     477     506 .. 0.91
   6 ?    0.4   0.1      0.34     1e+03      18      30 ..     655     667 ..     651     668 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.4
         PPR   3 ynslIsgycknGkleeAlelfk 24 
                 y +l+  y++ Gk + ++ lf+
  EFC38326.1 176 YHCLLVIYAHTGKQDLCENLFN 197
                 7778888888888777777776 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0003
         PPR   2 tynslIsgycknGkleeAl 20 
                 +y s++++y+  G++e+Al
  EFC38326.1 257 IYQSMVNAYSIMGNFEKAL 275
                 699***************8 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0029
         PPR   1 vtynslIsgycknGkleeAlelfkeM 26 
                 +t n+lI+ y+  Gkl  +++ f+ +
  EFC38326.1 333 ITLNTLINIYGLLGKLPYMIKHFQML 358
                 589************99888888766 PP

  == domain 4  score: 24.0 bits;  conditional E-value: 9.8e-09
         PPR   1 vtynslIsgycknGkleeAlelfkeMkekGi 31 
                 +t++++I+ +c n  ++ Al++f++Mke +i
  EFC38326.1 371 ITFTTVIRHLCMNDHFDSALDMFNRMKELNI 401
                 69*************************9876 PP

  == domain 5  score: 9.1 bits;  conditional E-value: 0.00057
         PPR  10 ycknGkleeAlelfkeMkekGi 31 
                 yck ++++ A  l+ eM+e+G+
  EFC38326.1 485 YCKINNFSRARFLIYEMLERGV 506
                 ********************97 PP

  == domain 6  score: 0.4 bits;  conditional E-value: 0.34
         PPR  18 eAlelfkeMkekG 30 
                 e+++++ eMk+++
  EFC38326.1 655 EMKQFYLEMKRNN 667
                 78999******97 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       2.4   7.1e+03      26      43 ..      11      28 ..       7      31 .. 0.83
   2 ?    0.3   0.1      0.25   7.5e+02      18      39 ..     176     197 ..     171     200 .. 0.85
   3 ?   -2.3   0.1       1.6   4.8e+03      19      42 ..     259     282 ..     257     296 .. 0.59
   4 ?    3.7   0.1     0.022        65       9      31 ..     326     348 ..     321     359 .. 0.84
   5 !   25.3   0.3     4e-09   1.2e-05      13      58 ..     368     413 ..     357     416 .. 0.91
   6 ?    0.8   0.1      0.17   5.2e+02       2      41 ..     426     466 ..     425     475 .. 0.71
   7 !    7.0   0.1     0.002       6.1      18      57 ..     478     517 ..     462     520 .. 0.87
   8 ?    1.8   0.1     0.085   2.5e+02       5      32 ..     662     689 ..     660     722 .. 0.73

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2.4
       PPR_3 26 anagnkklalevlermkk 43
                ++a+n +  +++++ +kk
  EFC38326.1 11 VYAKNINNHFNIVKLVKK 28
                678899999999999997 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.25
       PPR_3  18 YthLLtayanagnkklalevle 39 
                 Y  LL  ya +g+++l ++ ++
  EFC38326.1 176 YHCLLVIYAHTGKQDLCENLFN 197
                 7779999********9988775 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.6
       PPR_3  19 thLLtayanagnkklalevlermk 42 
                  ++ +ay   gn + al+   ++k
  EFC38326.1 259 QSMVNAYSIMGNFEKALYYATQVK 282
                 556666666666666665555544 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.022
       PPR_3   9 kgikldvvtYthLLtayanagnk 31 
                   i++d++t ++L++ y + g++
  EFC38326.1 326 HSIQYDGITLNTLINIYGLLGKL 348
                 679************99888876 PP

  == domain 5  score: 25.3 bits;  conditional E-value: 4e-09
       PPR_3  13 ldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailg 58 
                 ++ +t+t+ ++    +   + al  ++rmk+  ikPt+vty ++l+
  EFC38326.1 368 VNAITFTTVIRHLCMNDHFDSALDMFNRMKELNIKPTRVTYKVLLE 413
                 7999********999****************************995 PP

  == domain 6  score: 0.8 bits;  conditional E-value: 0.17
       PPR_3   2 ilremerkgikldvvtYthL.Ltayanagnkklalevlerm 41 
                 i+++m+ ++i +d     ++ L  + +++n++ ++ +l  +
  EFC38326.1 426 IMQNMKYDNISMDDHLVGSIvLYYASRTRNEQQLMDILSVV 466
                 78899999999985444444133336899999999998766 PP

  == domain 7  score: 7.0 bits;  conditional E-value: 0.002
       PPR_3  18 YthLLtayanagnkklalevlermkkkgikPtvvtyNail 57 
                 Y hL   y +  n  +a   + +m + g++Pt+ t+   +
  EFC38326.1 478 YEHLVLFYCKINNFSRARFLIYEMLERGVTPTMRTFTHFI 517
                 99999999999999*********************97665 PP

  == domain 8  score: 1.8 bits;  conditional E-value: 0.085
       PPR_3   5 emerkgikldvvtYthLLtayanagnkk 32 
                 em+r+++ ld+  ++  L+a  n+   +
  EFC38326.1 662 EMKRNNLILDIRSFNLYLEALLNTEGSN 689
                 89*************9999998876555 PP

>> PPR_1  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.4      0.63   1.9e+03      10      16 ..     196     202 ..     195     203 .. 0.90
   2 ?   -3.1   0.0       2.3   6.8e+03      10      26 ..     258     274 ..     257     275 .. 0.83
   3 ?    4.3   0.1     0.011        34       3      22 ..     328     347 ..     326     348 .. 0.78
   4 !   22.4   0.4   2.5e-08   7.4e-05       6      34 .]     369     397 ..     367     397 .. 0.96
   5 ?    4.2   0.0     0.012        35       2      16 ..     400     414 ..     399     415 .. 0.89
   6 ?   -3.3   0.0       2.6   7.9e+03      17      26 ..     485     494 ..     478     498 .. 0.81
   7 ?    0.3   0.0      0.19   5.8e+02       1      14 [.     504     517 ..     504     518 .. 0.89
   8 ?   -3.4   0.1       2.8   8.3e+03       3      15 ..     707     719 ..     707     720 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.63
                 HHHHHHH CS
       PPR_1  10 YNtLIdG 16 
                 +Nt+I++
  EFC38326.1 196 FNTIINS 202
                 9****96 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 2.3
                 HHHHHHHHHHTS-HHHH CS
       PPR_1  10 YNtLIdGlCkaGrvdeA 26 
                 Y ++++++   G+ ++A
  EFC38326.1 258 YQSMVNAYSIMGNFEKA 274
                 88999999888999888 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.011
                 ----HHHHHHHHHHHHHTS- CS
       PPR_1   3 lkPdvvTYNtLIdGlCkaGr 22 
                 ++ d +T NtLI+ +   G+
  EFC38326.1 328 IQYDGITLNTLINIYGLLGK 347
                 567889*******8866665 PP

  == domain 4  score: 22.4 bits;  conditional E-value: 2.5e-08
                 -HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   6 dvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                 +++T++t+I  lC + + d A+++f++M+
  EFC38326.1 369 NAITFTTVIRHLCMNDHFDSALDMFNRMK 397
                 99**************************7 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.012
                 S----HHHHHHHHHH CS
       PPR_1   2 GlkPdvvTYNtLIdG 16 
                 ++kP+ vTY  L+ G
  EFC38326.1 400 NIKPTRVTYKVLLEG 414
                 69**********998 PP

  == domain 6  score: -3.3 bits;  conditional E-value: 2.6
                 HHHTS-HHHH CS
       PPR_1  17 lCkaGrvdeA 26 
                 +Ck ++  +A
  EFC38326.1 485 YCKINNFSRA 494
                 9*99998887 PP

  == domain 7  score: 0.3 bits;  conditional E-value: 0.19
                 SS----HHHHHHHH CS
       PPR_1   1 kGlkPdvvTYNtLI 14 
                 +G+ P+  T++  I
  EFC38326.1 504 RGVTPTMRTFTHFI 517
                 69********9877 PP

  == domain 8  score: -3.4 bits;  conditional E-value: 2.8
                 ----HHHHHHHHH CS
       PPR_1   3 lkPdvvTYNtLId 15 
                 ++Pd+ T  +LI 
  EFC38326.1 707 INPDIDTLHILIR 719
                 589****999996 PP

>> PPR_long  Pentacotripeptide-repeat region of PRORP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.5     0.045   1.3e+02      35     145 ..     162     275 ..     150     321 .. 0.63
   2 !   10.4   0.0    0.0001       0.3      89     133 ..     369     413 ..     350     440 .. 0.87
   3 !    5.2   0.0     0.004        12      97     130 ..     482     515 ..     453     529 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.045
                 HHHHHSSS---HHHHHHHHHHHHHC.HCSTT..THHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHHHH.HH-S---HHH.HH CS
    PPR_long  35 dkavaegvrlaqyhynvllylcskaeaases..kknkalargfevfeamkakgvspnEatvtalarlaaakedgdlafelvkeme.kagvsPrLRs.ya 129
                 +  +++++ l++ +y++ll + +++ +++      n+ ++++   +++m+ ++ + n   +  +  +  + ++ +++ +  ++ + + ++    R+ y+
  EFC38326.1 162 QVLIENQIPLTNDIYHCLLVIYAHTGKQDLCenLFNTIINSSNDNMNDMNDSN-DMNNINLNNINDMNNNMNNMNNSNNSNNSNNnSNNIYDSKRTiYQ 259
                 45567788888899999888888776544321133455777777777776644.344455555555555555555555444444313344443343377 PP

                 HHHHHHHHTT-HHHHH CS
    PPR_long 130 PaLaayckagdadkal 145
                  +  ay+ +g+ +kal
  EFC38326.1 260 SMVNAYSIMGNFEKAL 275
                 7777777777777775 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.0001
                 -HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S---HHHHHHHHH CS
    PPR_long  89 nEatvtalarlaaakedgdlafelvkemekagvsPrLRsyaPaLa 133
                 n  t+t+++r    ++ +d a ++ ++m++ +++P   +y  +L 
  EFC38326.1 369 NAITFTTVIRHLCMNDHFDSALDMFNRMKELNIKPTRVTYKVLLE 413
                 5679*******************************9999988876 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.004
                 HHHHHHTT-HHHHHHHHHHHHHH-S---HHHHHH CS
    PPR_long  97 arlaaakedgdlafelvkemekagvsPrLRsyaP 130
                 +    + +++ +a  l+ em + gv+P +R++  
  EFC38326.1 482 VLFYCKINNFSRARFLIYEMLERGVTPTMRTFTH 515
                 55566778999********************975 PP

>> DAG_kinase_N  Diacylglycerol kinase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.3   0.00025      0.75      65     125 ..     189     248 ..     171     284 .. 0.60
   2 ?   -1.5   0.0      0.87   2.6e+03       4      19 ..     575     590 ..     573     602 .. 0.84
   3 ?    0.6   0.2      0.19   5.6e+02      44      85 ..     663     733 ..     644     798 .. 0.45

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00025
  DAG_kinase_N  65 eelcqrLFlsFqkkesqeespesqkkeasksssseenvlkkseesllkskkkkkekkekkk 125
                   ++lc+ LF    +++++++++ + +++ ++ + ++ n ++++ +++++s++++++++ +++
    EFC38326.1 189 QDLCENLFNTIINSSNDNMNDMNDSNDMNNINLNNINDMNNNMNNMNNSNNSNNSNN-NSN 248
                   79************9998886655555554433333333222222211111111111.111 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.87
  DAG_kinase_N   4 sLsPeeFaqLqkYieY 19 
                    L  ++F+qLq  ie 
    EFC38326.1 575 MLQKVDFTQLQTKIEH 590
                   57889******98875 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.19
  DAG_kinase_N  44 e.....pidyegFklFlktYLevdlpeelcqrLFlsFqkkesqees............................p 85 
                   +      +d+  F l+l++ L      e ++ ++ +F++ ++++e                             +
    EFC38326.1 663 MkrnnlILDIRSFNLYLEALL----NTEGSNSMWKYFNTCQTSTEIikinpdidtlhilirsirdfndmefilsK 733
                   445555566666666555555....45556666777766644433233333333333333333333333333330 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (804 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1750  (0.0976072); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.78u 0.35s 00:00:01.12 Elapsed: 00:00:00.51
# Mc/sec: 4778.76
//
Query:       EFC38327.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-35  123.0   2.9    2.4e-35  122.4   2.9    1.3  1  RNA_lig_T4_1  RNA ligase
  ------ inclusion threshold ------
      0.016   15.1   2.7        0.4   10.5   0.4    2.7  2  HPD           Homeo-prospero domain
        2.6    8.1   5.6        1.5    8.8   0.3    3.0  3  Mistic        Membrane-integrating protein Mistic


Domain annotation for each model (and alignments):
>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  122.4   2.9   3.9e-39   2.4e-35       1     220 []      80     298 ..      80     298 .. 0.84

  Alignments for each domain:
  == domain 1  score: 122.4 bits;  conditional E-value: 3.9e-39
  RNA_lig_T4_1   1 eaRGLfteenkeerIvvRgydKFFNinEveetkweeieqkt........qgpyelteKenGclilisalsdgklvvaSkhsleaeshaevgerllek 89 
                   e RGL +++++  ++v+R+++KFFN++E+ et+ e++e+k          + + ++eK +G++i+++ ++dgk+v+ +k +   ++ ++ ++++++ 
    EFC38327.1  80 EIRGLAFDKDS-GKLVSRCLHKFFNLDENAETNTEYLENKYnpngdcnlLDIFLVLEKLDGSMIMPI-IVDGKIVFRTKRGY-FNQVTNQADKFVA- 172
                   57*********.7***************************999999888888999************.**************.7777777776666. PP

  RNA_lig_T4_1  90 klekegkteeeLaeelleknlTavfElcddsfeehivaypeekagLyLhglnentp.efstesseevakfakefgfiktklitlesle...evkkfl 182
                      +++ ++ e++ +l+++++T++fE+ ++  e+ +v  + +++ L+L++++++++ +++ ++  e++++++ef++  +k+i  ++ +   + k+++
    EFC38327.1 173 ---ESQVKYLEFCTKLMKEGYTPIFEFYSK--ENMVVIEY-DSTFLTLIAIRYTEKgDYVPYN--EMCEMCNEFSIPFVKCIFSNTDQdeqSKKTVI 261
                   ...588889*********************..9**99999.***************9***999..**********5555555444444445333344 PP

  RNA_lig_T4_1 183 eevaetgs..wegeeiEGfVvrcksk.kdffFklKfkepyy 220
                   ++ ++ +s   + + iEG+V+r k++ +    ++Kfk+++y
    EFC38327.1 262 KSFKQLKSkvNTIKGIEGVVIRHKVSgE----MFKFKTNWY 298
                   455555442112347********77655....699****99 PP

>> HPD  Homeo-prospero domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.4   6.7e-05       0.4      68     143 ..     196     271 ..     152     277 .. 0.89
   2 ?    3.7   0.1    0.0083        50     112     143 ..     375     406 ..     355     415 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 6.7e-05
         HPD  68 gvkeaeelkvsrdselfralnlhynknndlevPdeflevveltlreffeaikagkdadpsWkkaiykviakldsei 143
                   ++++ + +  ds ++  + + y  + d+   +e++e+ ++    f++ i ++ d+d+  kk++ k   +l s++
  EFC38327.1 196 FYSKENMVVIEYDSTFLTLIAIRYTEKGDYVPYNEMCEMCNEFSIPFVKCIFSNTDQDEQSKKTVIKSFKQLKSKV 271
                 556788899999***************99988899********************************999998887 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0083
         HPD 112 reffeaikagkdadpsWkkaiykviakldsei 143
                 +e  + i ++  +++ +kk +yk+ +++d++ 
  EFC38327.1 375 KETASYIAQESGHNTIFKKIVYKIKTEIDKKT 406
                 5667778889999999************9975 PP

>> Mistic  Membrane-integrating protein Mistic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.12   7.3e+02      12      43 ..     186     215 ..     181     222 .. 0.85
   2 ?   -4.1   0.1       2.7   1.6e+04      54      62 ..     266     274 ..     259     274 .. 0.81
   3 ?    8.8   0.3   0.00026       1.5      12      46 ..     323     357 ..     322     370 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.12
                 TTHHHHHHHHH--SSS-SS-SS-SHHHHHHHH CS
      Mistic  12 mnegldafieLYNeseedkpliefeeevleai 43 
                 m+eg   + e+Y  s+e+  +ie++   l  i
  EFC38327.1 186 MKEGYTPIFEFY--SKENMVVIEYDSTFLTLI 215
                 899999999999..678999999998777666 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 2.7
                 S-HHHHHHH CS
      Mistic  54 vvnkKiNti 62 
                  +++K+Nti
  EFC38327.1 266 QLKSKVNTI 274
                 567899997 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00026
                 TTHHHHHHHHH--SSS-SS-SS-SHHHHHHHHHHH CS
      Mistic  12 mnegldafieLYNeseedkpliefeeevleaiekA 46 
                 m++ +d +i + N  +e ++l +f++evl+ai   
  EFC38327.1 323 MDDCIDDIIPVLNTEKEKQELRRFNDEVLNAIDDC 357
                 8999***************************9864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       979  (0.0546043); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2538.95
//
Query:       EFC38328.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.8e-28   97.7   0.0    1.8e-27   96.5   0.0    1.6  1  ABC_tran  ABC transporter
    1.9e-07   30.7   0.3    1.8e-05   24.3   0.0    2.1  2  SMC_N     RecF/RecN/SMC N terminal domain
    0.00031   20.6   1.0    0.00091   19.1   0.6    1.8  2  AAA_21    AAA domain, putative AbiEii toxin, Type IV TA syste
    0.00077   19.5   0.0      0.002   18.2   0.0    1.7  1  MMR_HSR1  50S ribosome-binding GTPase
  ------ inclusion threshold ------
      0.043   13.6   0.0      0.096   12.4   0.0    1.5  1  AAA_29    P-loop containing region of AAA domain
      0.082   13.4   1.0       0.16   12.5   1.0    1.5  1  AAA_23    AAA domain


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   96.5   0.0   6.1e-31   1.8e-27       2     137 .]      12     174 ..      11     174 .. 0.94

  Alignments for each domain:
  == domain 1  score: 96.5 bits;  conditional E-value: 6.1e-31
                 EEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--....SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH......HHHTCHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxx RF
    ABC_tran   2 knvslklkegekvaivGenGaGKStLlkllagllkp....teGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren......esdeeiekals 90 
                 +nv++++ +g+k ai+G++ +GKS+L+++l++  +     ++  i l+g+d+++ +l+ lr +i+++pq p lf ++ +ren      +sdeei  a++
  EFC38328.1  12 RNVTFSVAPGSKCAIIGRTASGKSSLFNCLLRFQEIendnNNSGIYLNGTDVRDLSLHALRTSISFIPQSPVLFLGT-LRENldfnnsNSDEEIWSAIE 109
                 79*****************************998875555666789*******************************.**********99********* PP

                 HSTTGG..................TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxx..................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  91 klglke..................lkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                 ++gl+e                  + d  +++++s++S G+kq ++lar++lkk+klll+DE+ta
  EFC38328.1 110 QVGLSEllerkvckesqsmpnikeILDYSISENGSNFSCGEKQLICLARSILKKSKLLLMDEATA 174
                 ********************99998888888999*****************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.8   0.1    0.0054        16      27      44 ..      24      41 ..      11      46 .. 0.83
   2 !   24.3   0.0   6.1e-09   1.8e-05     105     212 ..      50     218 ..      42     225 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0054
                EEEEESTTSSHHHHHHHH CS
                xxxxxxxxxxxxxxxxxx RF
       SMC_N 27 taivGpNGSGKsnlldAi 44
                 ai+G+  SGKs+l++ +
  EFC38328.1 24 CAIIGRTASGKSSLFNCL 41
                58************9876 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 6.1e-09
                 TTSEEEEEETTEEE-HHHHHHHHHCTT-STT................................................................CS-H CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................................................................xxxx RF
       SMC_N 105 rkgeseykingkevtkkevsellesagiske................................................................lLSg 139
                  +++s +++ng++v+   ++ l  s  + ++                                                                ++S 
  EFC38328.1  50 DNNNSGIYLNGTDVRDLSLHALRTSISFIPQspvlflgtlrenldfnnsnsdeeiwsaieqvglsellerkvckesqsmpnikeildysisengsNFSC 148
                 4677999999999999999999999999999999999999999999999999999999***************************************** PP

                 HHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHH.HHCTTSEEEEE-SSHHHCCC-SCEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 140 GektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellk.eksknaQfivislreemlekadklvgvt 212
                 Gek+L+ la        k++ l l+De  a+ D    +++ + l+    +n+ +i i++r e++++ d+++ ++
  EFC38328.1 149 GEKQLICLA----RSILKKSKLLLMDEATANVDSFTDSQIQKTLRgPLFNNCTIITIAHRIETVKDYDRIILMK 218
                 *****9876....55678999************************778999****************9998765 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.6     3e-07   0.00091       3     101 ..      25     119 ..      24     139 .. 0.80
   2 ?   -0.7   0.0      0.33   9.9e+02     237     265 ..     146     171 ..     132     203 .. 0.79

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 3e-07
      AAA_21   3 vliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldlydpeipfefeieeflsqgvryryglrlersqveeklssvetllesgllld 101
                 ++iG+ +sGKS+L+ +l  +   +   ++ +++    +g+++ + +l    ++i+f  + + +++   r +  ++  +s+  e +s+ e++++s ll +
  EFC38328.1  25 AIIGRTASGKSSLFNCLLRF---QEIENDNNNSGIYLNGTDVRDLSLHALRTSISFIPQSPVLFLGTLRENLDFNNSNSDE-EIWSAIEQVGLSELLER 119
                 69***************887...6677777777777777777777777777777777777777777777777777777777.88988888888887766 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.33
      AAA_21 237 lSdGtkrllalltallralkkgsllliDE 265
                 +S G k+l++l+ ++l      +lll DE
  EFC38328.1 146 FSCGEKQLICLARSILKKS---KLLLMDE 171
                 6779999988888888655...9999999 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.0   6.7e-07     0.002       2      23 ..      24      45 ..      23      68 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.7e-07
                EEEEESTTSSHHHHHHHHHTST CS
    MMR_HSR1  2 vaivGrpNvGKStLinaltgek 23
                +ai+Gr+ +GKS+L+n l++ +
  EFC38328.1 24 CAIIGRTASGKSSLFNCLLRFQ 45
                89****************9853 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.2e-05     0.096      15      39 ..      14      38 ..      10      44 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.2e-05
      AAA_29 15 htieidlkgatlltGpsGsGKSTll 39
                 t+++ + + + ++G++ sGKS+l+
  EFC38328.1 14 VTFSVAPGSKCAIIGRTASGKSSLF 38
                67778877799************98 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   1.0   5.3e-05      0.16      23      64 ..      25      64 ..      11     189 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.3e-05
      AAA_23 23 lItGpNGaGKTTildAiklaLygetprlsrksgrgfeksdve 64
                +I+G + +GK+++++++    + e ++ +++sg  ++  dv+
  EFC38328.1 25 AIIGRTASGKSSLFNCLLR--FQEIENDNNNSGIYLNGTDVR 64
                79*************9843..666666666666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       534  (0.0297841); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 1630.64
//
Query:       EFC38329.1  [L=998]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.3e-40  137.5   0.1    1.3e-39  135.9   0.1    1.7  1  SNF2_N         SNF2 family N-terminal domain
    5.2e-16   59.0   0.3    2.2e-15   57.0   0.3    2.2  1  Helicase_C     Helicase conserved C-terminal domain
    4.2e-14   52.9   7.6    7.2e-14   52.2   0.0    3.7  3  ResIII         Type III restriction enzyme, res subunit
    5.3e-07   28.8   0.2    1.3e-06   27.6   0.2    1.6  1  AAA_34         P-loop containing NTP hydrolase pore-1
      2e-06   27.7   0.1      2e-06   27.7   0.1    3.0  3  SWI2_SNF2      SWI2/SNF2 ATPase
    4.6e-06   26.0   1.5    4.6e-06   26.0   1.5    2.9  3  ERCC3_RAD25_C  ERCC3/RAD25/XPB C-terminal helicase
    0.00049   19.4   2.2     0.0022   17.2   2.2    2.1  1  HDA2-3         Class II histone deacetylase complex subunits 
  ------ inclusion threshold ------
       0.39   11.1   6.5        4.3    7.7   0.5    3.1  3  DUF2716        Protein of unknown function (DUF2716)
        6.3    7.4   5.7        2.9    8.5   0.3    3.2  4  Pox_A21        Poxvirus A21 Protein


Domain annotation for each model (and alignments):
>> SNF2_N  SNF2 family N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  135.9   0.1   6.7e-43   1.3e-39      52     349 ..     328     633 ..     309     634 .. 0.76

  Alignments for each domain:
  == domain 1  score: 135.9 bits;  conditional E-value: 6.7e-43
                 HHTT--EEE---TTS--HHHHHHHHH...HHTTTS---.......S-EEEE--HHHHHHHHHHHHHH-TTS-EEE--SSHHHH......---------- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxx RF
      SNF2_N  52 kqsvrGGiLaDemGLGKTvqvlalilaqrakeekdkekkrkdtlagptLivvPaslldqWeneierhvsssalrvlvyggqkk......mkkkntkvap 144
                  +s +GG+LaD+mGLGKT+q+ ++i+ +   ++              +L+++P s++ +W++e+e++  ++   v++ ++  k      +++  +k ++
  EFC38329.1 328 ASSLKGGLLADDMGLGKTIQISSFIHGLFLTQKAS-----------RVLVICPNSVVGNWQKELEKWGGDQIKGVVIFHQVGKasstnrKRQGFVKEFE 415
                 56789*********************555533333...........39*******************99987777777777665666543333344455 PP

                 -------.EEEE-HHHHHHHT......TTS-.S-S-SEEEES-GGGT--TTSHHHHHHHH---S-EEEE-S--SSS-HHHHHHHHHH.H-TTTT--HHH CS
                 xxxxxxx.xxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxx RF
      SNF2_N 145 klladyd.vvittYdvlsreaelqkkrsvlk.qvewkrvvlDEghtlknstskaaeavskLstsnrwiltGTPiqnsledlygLlkf.Lreepfgekqt 240
                 k++++ + v++ tY+++++++e+    + ++ ++  + +++DE+h++kn+++k ++a+++L +  +  ltGTPi n+l++ly++ +   +e+ +g+   
  EFC38329.1 416 KYAKQGGaVMLSTYQTIANHVEYL--SKSFSgDKLLDSIIIDEAHKIKNKDAKCSMALKTLGSASKFGLTGTPIMNKLTELYSIYSWcFGEDLLGSVSE 512
                 66655444999*******999754..34444055589***********************************************99636899******* PP

                 HHHHTHHHHH............HHHHHHHHHHHTT-ST..............TEE---GGGT--S---EEEEEEEEE--HHHHHHHH............ CS
                 xxxxxxxxxx............xxxxxxxxxxxxxxxx..............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 241 fdkllqrpie............aqaekgrsrLlqllqr..............lmlrrakkdveknlPpkteeiiflklskverksYnrllevlrkkala 313
                 f++ +++pi+               +  +  L++l+++               +l ++ +++++++ +k+  i+++kl+++++++Y++   +l  + ++
  EFC38329.1 513 FSSNYSTPINqstrrdanytqkMAGNRAADDLRELVKPyllmrgknavltidKNLYKSSSNTSAKIGQKNDLIVWCKLTDEQQHWYKE---YLSSDDVK 608
                 **********9999999988544445556678999998444455555554444444444444789**********************3...33333333 PP

                 ........HHHHHH-HHH-HHHHHHHHHHHHH---X CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 314 kllkrseaalkssskskekilelllelrqacnhpql 349
                 ++l++            +  l  +  l+q+cnh ++
  EFC38329.1 609 QVLNKT-----------MSALVGIVILKQVCNHAIM 633
                 333332...........2257788888888888766 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.0   0.3   1.1e-18   2.2e-15       6     111 .]     723     833 ..     718     833 .. 0.88

  Alignments for each domain:
  == domain 1  score: 57.0 bits;  conditional E-value: 1.1e-18
                 HHHHH..HHTTTTSEEEEEESSHHHHHHHHHHHHHTTSTEEEESTT.STHHHHHHHHHHHH.TTSSS.EEEESGGGTSSSTSTTESEEEESSSSSSHHH CS
  Helicase_C   6 llell..kleeeggkilifvntidrlekvklllekkgikvavlhge.lpqnereeileqfn.kgesd.vLiatdvaerGidipkvnlVinfdlprnvts 99 
                 l++ l  k +eeg+++lif++++++l+ +  +l++ ++k+ +++g+ + +++r + +++fn +++++ +++++++++ G+++ +++ Vi++d+ +n++ 
  EFC38329.1 723 LVKHLveKCNEEGHRVLIFSQYTRMLDIIGHVLKSMKVKFNRIDGSvTRHQDRTQLVDEFNeNEKIKcFILSSQAGGVGLNLVSASRVIIVDANFNPSI 821
                 3344447889****************98777777779********845678899*******7788999******************************* PP

                 HHHHHTTSSSTT CS
  Helicase_C 100 yiqriGRtgRag 111
                   q+++R++R+g
  EFC38329.1 822 DEQSVDRCYRIG 833
                 **********97 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   2.1      0.35   6.9e+02      96     134 ..     159     202 ..     114     229 .. 0.56
   2 !   52.2   0.0   3.6e-17   7.2e-14       3     170 ..     310     487 ..     308     488 .. 0.88
   3 ?    0.9   0.1       0.2   4.1e+02      63      96 ..     959     990 ..     957     997 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.35
                 -............-SEEEEEHHHHHHTH........HHHTTT-S CS
      ResIII  96 a.....kekdstnkkilvttiqsldadseeeeeeseellrdrfd 134
                       ++k++ +k++++++ ++ +ad+e ee+++e +l++++d
  EFC38329.1 159 VeifksEKKEIIKKEVVLSESEESSADEEAEEQDEELMLDEEED 202
                 22232223333455555555555555554444444444443333 PP

  == domain 2  score: 52.2 bits;  conditional E-value: 3.6e-17
                 EE-HHHHHHHHHHT......TTSEEEEEESTTSTHHHHHHHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG..........GEEEESSS-B- CS
      ResIII   3 elreyQeeaienlleklkskrdkrglikmaTGtGKTlvaaklierllkkgkeekflflvprkslleqtleefkkflseayke......igkkvsgdkkk 95 
                 +l+++Q+  ++ l+e   +   k gl++   G GKT+ + ++i  l+  +k +++l+++p+ s++  +++e++k+  ++ k       +gk  s ++k+
  EFC38329.1 310 KLYSHQQIGVKWLVERHFASSLKGGLLADDMGLGKTIQISSFIHGLFLTQKASRVLVICPN-SVVGNWQKELEKWGGDQIKGvvifhqVGKASSTNRKR 407
                 57889999999988877779999*************************************7.688899999*999999988888888666666666666 PP

                 -.............-SEEEEEHHHHHHTH........HHHTTT-S.EEEEETGGGTTS.T.TTHHHHHT---SEEEEEESS-S CS
      ResIII  96 a......kekdstnkkilvttiqsldadseeeeeeseellrdrfd.viiiDEaHrlgakk.swreilekfkeavllglTATpe 170
                 +      ++++++   ++++t+q++ ++    e+ s++++ d+ +  iiiDEaH+++ k+ +   +l+ + +a ++glT+Tp 
  EFC38329.1 408 QgfvkefEKYAKQGGAVMLSTYQTIANHV---EYLSKSFSGDKLLdSIIIDEAHKIKNKDaKCSMALKTLGSASKFGLTGTPI 487
                 6899999999*******************...88888888877656***********9744888899**************95 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.2
                 SHHHHHHHHHHGGGGTGG....GEEEESSS-B-- CS
      ResIII  63 rkslleqtleefkkflseaykeigkkvsgdkkka 96 
                 r++l ++++e+f+k++ +  ++   +++ d++k+
  EFC38329.1 959 RIELAKKMREAFQKIAGSSSNS--SEIKPDGEKQ 990
                 799**************99854..4455444444 PP

>> AAA_34  P-loop containing NTP hydrolase pore-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   0.2   6.4e-10   1.3e-06      60     210 ..     331     492 ..     293     501 .. 0.69

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 6.4e-10
      AAA_34  60 RaGfllGDgaGvGkgrqiagiilenllqgrkkavwvsvsedLkeDaerDlkdigaseievval.nklkegkkikeseelkeGvl..FvtYstliseskk 155
                  +G ll D++G+Gk+ qi+++i+  +l+++   v v   +  +   +++l+  g ++i+ v++ +++ +    + +++ ++G +  F  Y++  ++   
  EFC38329.1 331 LKGGLLADDMGLGKTIQISSFIHGLFLTQKASRVLVICPNSVVGNWQKELEKWGGDQIKGVVIfHQVGK---ASSTNRKRQGFVkeFEKYAKQGGAVML 426
                 467799*********************99999999999999***************8875444033333...333445555544445555555544444 PP

      AAA_34 156 kkksrleqlveWlgedfdG.....vivfDEchkaknlakse......ekkatktgkavlelqkklp 210
                 ++ + +++ ve+l+++f G      i+ DE+hk+kn +++        ++a+k g +++ +++kl 
  EFC38329.1 427 STYQTIANHVEYLSKSFSGdklldSIIIDEAHKIKNKDAKCsmalktLGSASKFGLTGTPIMNKLT 492
                 44444555555555555555544499**********987654444444555777777777777765 PP

>> SWI2_SNF2  SWI2/SNF2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.1   9.8e-10     2e-06       1     163 [.     314     492 ..     314     505 .. 0.68
   2 ?   -1.7   0.7      0.93   1.8e+03      57     110 ..     678     736 ..     675     785 .. 0.63
   3 ?   -2.1   0.3       1.3   2.6e+03      79     127 ..     875     932 ..     855     974 .. 0.48

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 9.8e-10
   SWI2_SNF2   1 qQyravekavervkegdrkgGviWHtqGSGKsltmvflakklleeelknpkvvvvtD.......RkdLdk....Qlskt..fakageekpkqaesrkeL 86 
                 +Q ++v+ +ver  +++ kgG++    G GK+++   + + l   ++k  +v+v+          k+L+k    Q+++   f+++g+++ ++ ++r+ +
  EFC38329.1 314 HQQIGVKWLVERHFASSLKGGLLADDMGLGKTIQISSFIHGLFL-TQKASRVLVICPnsvvgnwQKELEKwggdQIKGVviFHQVGKAS-STNRKRQGF 410
                 78899999999999999999999999999999998888888887.66666776665312222226788752222555432234444444.466666667 PP

   SWI2_SNF2  87 kell...ekesekiifttiqKfeeeekeklevlsere.niivlvDEaHRsqygelakklr.kalpnaafigFTGTPilkkdk 163
                 ++++   +k+ + ++++t q ++++ +   + +s ++    +++DEaH+ + ++ + ++  k+l  a+ +g+TGTPi++k  
  EFC38329.1 411 VKEFekyAKQGGAVMLSTYQTIANHVEYLSKSFSGDKlLDSIIIDEAHKIKNKDAKCSMAlKTLGSASKFGLTGTPIMNKLT 492
                 7776322256888999999999765332223333333133699**********9999996589**************98754 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.93
   SWI2_SNF2  57 DRkdLdkQlsktfaka....geekpkqaesrkeLkelleke.sekiifttiqKfeeeek 110
                 D +dLd+   k +++     +++  k+  +++ +++l++++ +++++  +++K +ee +
  EFC38329.1 678 DMDDLDDKQRKAMERRlkkiQDDLIKERIRNEPIEQLISSSvKAQLVKHLVEKCNEEGH 736
                 66788877777777652221233333444455677777655588888888888876533 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.3
   SWI2_SNF2  79 qaesrkeLkell..ekesekiifttiqKfeeeek.......eklevlsereniivlvD 127
                 +  s+++L+e++  +k+s++  ++ +++++++++       e++e l++ en++ + D
  EFC38329.1 875 RYLSHADLEEMFtlKKTSHSETCSRMNRIHSKDRrdcdgleEHIESLKQMENVVGISD 932
                 5555666666553234455555555555553322344455444455555555555544 PP

>> ERCC3_RAD25_C  ERCC3/RAD25/XPB C-terminal helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   1.8       2.8   5.6e+03     212     239 ..     163     192 ..     147     216 .. 0.48
   2 !    4.4   0.0    0.0093        19      15      40 ..     586     614 ..     575     619 .. 0.77
   3 !   26.0   1.5   2.3e-09   4.6e-06      41     182 ..     716     857 ..     701     923 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 2.8
  ERCC3_RAD25_C 212 keeqkellqk..vlaakdeeaeeeelekel 239
                    k+e+ke+++k  vl++++e++ +ee+e++ 
     EFC38329.1 163 KSEKKEIIKKevVLSESEESSADEEAEEQD 192
                    333344443311233333333333333322 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0093
  ERCC3_RAD25_C  15 vWcpmtae...fykeylkakskkkkllyv 40 
                    vWc++t e   +ykeyl+++  k+ l  +
     EFC38329.1 586 VWCKLTDEqqhWYKEYLSSDDVKQVLNKT 614
                    9****9644449******99988876555 PP

  == domain 3  score: 26.0 bits;  conditional E-value: 2.3e-09
  ERCC3_RAD25_C  41 mnpnkfracefLikyhekrgDkiivfsDnvfaLkeyakklkkp...y..iyGe.tseaerlkilqkfkknpkvntifls.kvgDtsiDlPeanvli 129
                      + k + +++L++  ++ g ++++fs     L  +++ lk +   +  i G+ t++++r++++++f++n+k+++ +ls + g   ++l +a+ +i
     EFC38329.1 716 SSSVKAQLVKHLVEKCNEEGHRVLIFSQYTRMLDIIGHVLKSMkvkFnrIDGSvTRHQDRTQLVDEFNENEKIKCFILSsQAGGVGLNLVSASRVI 811
                    55679999********************9999988776655431113448998346789****************888538999************ PP

  ERCC3_RAD25_C 130 qisshfgsrrqeaqrlGriLrakkksneeefnaffYsLvskDtkemaystkrq 182
                     ++++f     e q + r  r  +k      n   Y L+s  t e  y  krq
     EFC38329.1 812 IVDANFNPSIDE-QSVDRCYRIGQK-----ENVIVYRLISAGTIEE-YIYKRQ 857
                    ******988766.889999988777.....689999****999884.555666 PP

>> HDA2-3  Class II histone deacetylase complex subunits 2 and 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   2.2   1.1e-06    0.0022      78     251 ..     706     861 ..     702     876 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.1e-06
                 -STTHHHHHHHT-HHHHHHHHHHHHHTTSS....EEEEEEE-STHHHHHHHHHHTTSSSEEEESSS--S--S---S-..................-SEE CS
      HDA2-3  78 llkelpeklaetSgKFkvlndlvnliierkrksslnvlvvakskkeldLiEalllGkklkikrysgeklydekkkkskdtkknsrktkeklkkkihslt 176
                  ++e+ e+l+++S K ++ ++lv+   e+       vl+ ++  + ld+i  +l + k+k++r +g    ++ + +  d+            +++ + +
  EFC38329.1 706 IRNEPIEQLISSSVKAQLVKHLVEKCNEEG----HRVLIFSQYTRMLDIIGHVLKSMKVKFNRIDGSVTRHQDRTQLVDEF-----------NENEKIK 789
                 578999*************99999999998....9*******************************988888777772222...........2334455 PP

                 EEEEESS---TTTS--TT-S-EEEEEE-SST--TTSHHHHHHH---.-------EEEEEETTSHHHHHHHHTS-TT CS
      HDA2-3 177 ihllsttrqltkdksllenikfdliiafDssvdtsspsveslrtqn.rkknklpiirlvpinSieHvkLcfkkded 251
                 + +ls++         l+ + ++ +i +D ++++s ++ +  r  +  +k++++++rl++  +ie + + ++ +++
  EFC38329.1 790 CFILSSQAG----GVGLNLVSASRVIIVDANFNPSIDEQSVDRCYRiGQKENVIVYRLISAGTIEEYIYKRQVSKT 861
                 555554433....345666777778999999999977666666544233455*************99888774433 PP

>> DUF2716  Protein of unknown function (DUF2716)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.5    0.0021       4.3      26      63 ..     135     172 ..     126     228 .. 0.76
   2 ?    5.1   0.3     0.013        27      12      65 ..     650     702 ..     639     713 .. 0.69
   3 ?   -2.0   0.0       2.2   4.3e+03      19      53 ..     816     853 ..     813     903 .. 0.67

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0021
     DUF2716  26 eselpsieepapsvtydlsaledekeeakealdavedk 63 
                 es    +ee++p v++d+s+ ed+ e +k++++++ +k
  EFC38329.1 135 ESSGSEFEESSPQVVFDISSDEDSVEIFKSEKKEIIKK 172
                 4445689********************99988887654 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.013
     DUF2716  12 dkvykrfkfkPstdeselpsieepapsvtydlsaledekeeake.aldavedkil 65 
                 ++ +++f    + +++++    e aps+++d+ +l+d++ +a e +l++++d  +
  EFC38329.1 650 EEAKEDFGA--DSSDEDFIEESEVAPSMSFDMDDLDDKQRKAMErRLKKIQDDLI 702
                 555555555..33356666778899**********99987776557777776554 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 2.2
     DUF2716  19 kfkPstdeselp...sieepapsvtydlsaledekeea 53 
                 +f+Ps+de+ ++    i ++++ ++y l ++ + +e +
  EFC38329.1 816 NFNPSIDEQSVDrcyRIGQKENVIVYRLISAGTIEEYI 853
                 79999998766522257778888888776665555554 PP

>> Pox_A21  Poxvirus A21 Protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       6.2   1.2e+04      88     107 ..     453     472 ..     436     474 .. 0.79
   2 ?   -1.2   0.1       1.5     3e+03      41      90 ..     599     649 ..     581     660 .. 0.73
   3 ?    8.5   0.3    0.0014       2.9      16      99 ..     837     922 ..     829     928 .. 0.77
   4 ?   -2.0   0.0       2.7   5.4e+03      70      89 ..     933     952 ..     924     972 .. 0.69

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 6.2
     Pox_A21  88 sCddnekvkdfresCskAyl 107
                   d+++k+k+   +Cs A++
  EFC38329.1 453 IIDEAHKIKNKDAKCSMALK 472
                 55778889999999999876 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.5
     Pox_A21  41 kkvvCvddrlfsyeftatgikaklavdkkgk.plpCskikeieseklisCd 90 
                 k++   dd   + + t++ +   +++++  +  + Cs  +ei ++k  + +
  EFC38329.1 599 KEYLSSDDVKQVLNKTMSALVGIVILKQVCNhAIMCSGYDEIMKKKKKELE 649
                 566667777777777888888888887776548899999999888766555 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0014
     Pox_A21  16 niivpaileklrlekeafekykkl..kkkvvCvddrlfsyeftatgikaklavdkkgkplpCskikeieseklisCd.dnekvkdfr 99 
                 n+iv++++     e+ ++++  ++   +++  +  + ++y  + + +++ ++++k+++  +Cs+++ i+s+    Cd  +e++++++
  EFC38329.1 837 NVIVYRLISAGTIEEYIYKRQVSKttVSRTATIASNQYRYLSH-ADLEEMFTLKKTSHSETCSRMNRIHSKDRRDCDgLEEHIESLK 922
                 8999999999999999998866551244555555555555444.789999999999*********************6666666555 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 2.7
     Pox_A21  70 gkplpCskikeieseklisC 89 
                  + l C+++++i+s+ +   
  EFC38329.1 933 HDVLFCNQADDIDSDDAEIE 952
                 55788999999999876544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (998 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1752  (0.0977188); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.92u 0.31s 00:00:01.23 Elapsed: 00:00:00.46
# Mc/sec: 6452.99
//
Query:       EFC38330.1  [L=128]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       539  (0.030063); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.28s 00:00:00.71 Elapsed: 00:00:00.44
# Mc/sec: 868.42
//
Query:       EFC38331.1  [L=268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.039   13.3   0.0      0.081   12.3   0.0    1.4  1  Coatomer_E  Coatomer epsilon subunit


Domain annotation for each model (and alignments):
>> Coatomer_E  Coatomer epsilon subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   4.5e-06     0.081      76     133 ..      64     119 ..      51     130 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.5e-06
                 HH-STTHHHHHHHHHHHHHS----S-HHHHHHHHHHHHHTT-HHHHHHHHTT--SHHH CS
  Coatomer_E  76 lnspsrkeeilaelkeeladseiesnevlrllaaivflkegdfddalkllkksenLea 133
                 +++ ++k+ei++  ++e+ +s    n  + l+ +++f++ ++ ++al++lk+s+++++
  EFC38331.1  64 ITTKQTKDEIIDICDDEMVKSPL--NPYIPLMKGVLFNNSESINQALEILKNSKQINI 119
                 566799**************999..889*************************98876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1006  (0.0561102); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1745.57
//
Query:       EFC38332.1  [L=142]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (142 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1219  (0.0679904); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.38u 0.25s 00:00:00.63 Elapsed: 00:00:00.39
# Mc/sec: 1093.44
//
Query:       EFC38333.1  [L=172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.1e-28   93.7  17.0    6.4e-09   34.7   0.5    4.2  4  EF-hand_1        EF hand
    5.1e-26   90.9   7.2      2e-13   50.6   1.9    2.1  2  EF-hand_7        EF-hand domain pair
    2.2e-22   77.0  11.1    4.4e-08   32.4   0.2    4.4  4  EF-hand_6        EF-hand domain
    7.3e-21   73.8  11.8      2e-10   40.3   0.9    4.0  4  EF-hand_8        EF-hand domain pair
    4.7e-13   48.0  14.5    1.4e-06   27.5   0.4    4.6  4  EF-hand_5        EF hand
    1.6e-11   44.3   0.1    2.8e-05   24.4   0.0    2.2  2  EF-hand_9        EF-hand domain
      1e-05   25.4   3.9      0.038   13.8   0.5    2.2  2  SurA_N_3         SurA N-terminal domain
     0.0012   19.0   1.5        6.9    6.9   0.1    3.2  3  Dockerin_1       Dockerin type I domain
     0.0029   17.5   5.8      0.084   12.8   0.2    3.1  3  EF-hand_4        Cytoskeletal-regulatory complex EF hand
     0.0038   17.5   2.7      0.041   14.2   0.9    2.4  2  FlgD             Flagellar hook capping protein - N-terminal 
     0.0082   16.0   4.0       0.73    9.7   0.3    2.8  2  SurA_N_2         SurA N-terminal domain
     0.0089   16.3   1.7        2.6    8.4   0.1    2.5  2  EF-hand_14       EF-hand domain
  ------ inclusion threshold ------
      0.012   15.7   2.8        3.3    7.9   0.4    2.7  3  DUF3911          Protein of unknown function (DUF3911)
      0.027   13.8   0.4      0.043   13.1   0.4    1.3  1  SCF              Stem cell factor
      0.085   13.0   0.4       0.74    9.9   0.1    2.6  3  EFhand_Ca_insen  Ca2+ insensitive EF hand
        0.1   12.5   0.8         15    5.5   0.0    3.1  4  Caleosin         Caleosin related protein
       0.11   13.0   0.9        1.7    9.1   0.1    2.7  3  DUF4093          Domain of unknown function (DUF4093)
       0.57   10.4   0.0       0.57   10.4   0.0    2.5  3  DUF3008          Protein of unknwon function (DUF3008)
        0.9    9.8   4.1        1.7    8.9   0.1    2.9  3  SRI              SRI (Set2 Rpb1 interacting) domain


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.7   0.5   6.7e-12   6.4e-09       1      29 []      33      61 ..      33      61 .. 0.96
   2 !   21.1   0.4   1.5e-07   0.00014       1      28 [.      69      95 ..      69      96 .. 0.94
   3 !   22.8   0.7   4.5e-08   4.2e-05       1      28 [.     105     132 ..     105     133 .. 0.92
   4 !   25.7   0.2   5.1e-09   4.8e-06       1      28 [.     141     168 ..     141     169 .. 0.96

  Alignments for each domain:
  == domain 1  score: 34.7 bits;  conditional E-value: 6.7e-12
                HHHHHHHHHTTTSSSEEEHHHHHHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfkellkkl 29
                e+ke+F++fD Dg+GkId +E+k ++++l
  EFC38333.1 33 EIKEAFDLFDMDGSGKIDAKELKVAMRAL 61
                79************************975 PP

  == domain 2  score: 21.1 bits;  conditional E-value: 1.5e-07
                HHHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfkellkk 28
                e+k++++ +D +g+GkIdf++f++l+++
  EFC38333.1 69 EIKKMISGID-NGSGKIDFNDFLQLMTA 95
                799*******.***************86 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 4.5e-08
                 HHHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellkk 28 
                 e+ ++Fr+fD D +G+I+f  +k++ k+
  EFC38333.1 105 EIMKAFRLFDEDDSGFITFANLKRVAKD 132
                 799*******************999876 PP

  == domain 4  score: 25.7 bits;  conditional E-value: 5.1e-09
                 HHHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellkk 28 
                 el+e+++e+D+ + G+I++e+f++++kk
  EFC38333.1 141 ELREMIEEADRSNQGQISKEDFLRIMKK 168
                 79************************98 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.5   0.3   3.5e-14   3.3e-11       2      70 ..      32      93 ..      31      94 .. 0.95
   2 !   50.6   1.9   2.1e-16     2e-13       3      71 .]     105     167 ..     104     167 .. 0.97

  Alignments for each domain:
  == domain 1  score: 43.5 bits;  conditional E-value: 3.5e-14
   EF-hand_7  2 eklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkly 70
                +++keaF+++D dg+g++d  el+ ++r        g+++ +ee+++++  +D +++G+i+f++Fl+l+
  EFC38333.1 32 QEIKEAFDLFDMDGSGKIDAKELKVAMR------ALGFEPKKEEIKKMISGID-NGSGKIDFNDFLQLM 93
                78**********************9999......9****************99.888**********99 PP

  == domain 2  score: 50.6 bits;  conditional E-value: 2.1e-16
   EF-hand_7   3 klkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlklyr 71 
                 +++ aF+++D d++g+++ + l+r+ +      + g++++deel+++++e D ++ G+is ++Fl++++
  EFC38333.1 105 EIMKAFRLFDEDDSGFITFANLKRVAK------DLGENMTDEELREMIEEADRSNQGQISKEDFLRIMK 167
                 6999***********************......*********************************996 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.4   0.2   4.7e-11   4.4e-08       1      31 []      33      62 ..      33      62 .. 0.96
   2 !   13.0   0.1   7.8e-05     0.074      12      27 ..      79      94 ..      69      99 .. 0.91
   3 !   23.8   0.5   2.8e-08   2.7e-05       1      31 []     105     134 ..     105     134 .. 0.90
   4 !   12.7   0.0   9.7e-05     0.092       1      28 [.     141     168 ..     141     171 .. 0.88

  Alignments for each domain:
  == domain 1  score: 32.4 bits;  conditional E-value: 4.7e-11
   EF-hand_6  1 elreaFklfDkdgdGkidaeElrkalrkalg 31
                e++eaF+lfD dg+Gkida+El+ a+r alg
  EFC38333.1 33 EIKEAFDLFDMDGSGKIDAKELKVAMR-ALG 62
                699************************.887 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 7.8e-05
   EF-hand_6 12 dgdGkidaeElrkalr 27
                +g+Gkid++++ ++++
  EFC38333.1 79 NGSGKIDFNDFLQLMT 94
                8*************98 PP

  == domain 3  score: 23.8 bits;  conditional E-value: 2.8e-08
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalrkalg 31 
                 e+++aF+lfD d++G+i+++ l+++ + +lg
  EFC38333.1 105 EIMKAFRLFDEDDSGFITFANLKRVAK-DLG 134
                 6899*******************9988.665 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 9.7e-05
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalrk 28 
                 elre  ++ D+++ G+i++e++ ++++k
  EFC38333.1 141 ELREMIEEADRSNQGQISKEDFLRIMKK 168
                 577888899*****************95 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.5   3.7e-07   0.00035      26      52 ..      32      58 ..      18      60 .. 0.93
   2 !   32.4   0.2   6.5e-11   6.1e-08       2      53 ..      46      94 ..      46      96 .. 0.96
   3 !    6.3   0.4    0.0093       8.8      32      45 ..     110     123 ..     102     123 .. 0.89
   4 !   40.3   0.9   2.2e-13     2e-10       2      54 ..     118     168 ..     117     169 .. 0.95

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 3.7e-07
   EF-hand_8 26 eevdilfrefDtdgdGkisfeEFcvll 52
                +e+ + f++fD+dg+Gki+ +E  v +
  EFC38333.1 32 QEIKEAFDLFDMDGSGKIDAKELKVAM 58
                799999*****************9998 PP

  == domain 2  score: 32.4 bits;  conditional E-value: 6.5e-11
   EF-hand_8  2 kgkItreelrrilrilglkkglseeevdilfrefDtdgdGkisfeEFcvlle 53
                +gkI+  el+ ++r+lg +    +ee+  +++ +D +g+Gki+f++F++l++
  EFC38333.1 46 SGKIDAKELKVAMRALGFE--PKKEEIKKMISGID-NGSGKIDFNDFLQLMT 94
                59*****************..**************.9*************96 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0093
   EF-hand_8  32 frefDtdgdGkisf 45 
                 fr+fD+d++G i+f
  EFC38333.1 110 FRLFDEDDSGFITF 123
                 9*********9997 PP

  == domain 4  score: 40.3 bits;  conditional E-value: 2.2e-13
   EF-hand_8   2 kgkItreelrrilrilglkkglseeevdilfrefDtdgdGkisfeEFcvller 54 
                 +g It+++l+r ++ lg +  +++ee+++++ e+D+ + G is+e+F+  +++
  EFC38333.1 118 SGFITFANLKRVAKDLGEN--MTDEELREMIEEADRSNQGQISKEDFLRIMKK 168
                 79*********99****99..***************************99886 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.4   1.5e-09   1.4e-06       1      22 [.      34      55 ..      34      58 .. 0.91
   2 !    9.8   0.2   0.00059      0.56      11      25 .]      79      93 ..      78      93 .. 0.92
   3 !   12.2   0.2   0.00011       0.1       3      22 ..     108     127 ..     106     130 .. 0.81
   4 !    6.6   0.2    0.0061       5.8       2      25 .]     143     166 ..     142     167 .. 0.82

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 1.5e-09
                HHHHHHHH-SS-SSCE-HHHHH CS
   EF-hand_5  1 lkdtFqaiDlNgDGkIskeELk 22
                +k++F+ +D++g+GkI++ ELk
  EFC38333.1 34 IKEAFDLFDMDGSGKIDAKELK 55
                6789*****************8 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00059
                S-SSCE-HHHHHHHH CS
   EF-hand_5 11 NgDGkIskeELktlv 25
                Ng+GkI++  + +l+
  EFC38333.1 79 NGSGKIDFNDFLQLM 93
                9**********9986 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 0.00011
                 HHHHHH-SS-SSCE-HHHHH CS
   EF-hand_5   3 dtFqaiDlNgDGkIskeELk 22 
                 ++F+ +D + +G+I++  Lk
  EFC38333.1 108 KAFRLFDEDDSGFITFANLK 127
                 45************987555 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0061
                 HHHHHHH-SS-SSCE-HHHHHHHH CS
   EF-hand_5   2 kdtFqaiDlNgDGkIskeELktlv 25 
                 +++ +++D  + G+Iske + +++
  EFC38333.1 143 REMIEEADRSNQGQISKEDFLRIM 166
                 566788899999********8865 PP

>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   2.7e-06    0.0025       3      63 ..      37      94 ..      35      97 .. 0.92
   2 !   24.4   0.0     3e-08   2.8e-05       3      64 ..     109     168 ..     107     169 .. 0.93

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 2.7e-06
   EF-hand_9  3 vFevcDtqktGrVpvsrlidyLravtaqdpeeseLeelakelDPdgedasvdldtflrvmr 63
                 F+++D++  G++  ++l+  +ra +  +p+  e+ +  + +D  g  +++d+++fl+ m 
  EFC38333.1 37 AFDLFDMDGSGKIDAKELKVAMRALGF-EPKKEEIKKMISGIDN-GS-GKIDFNDFLQLMT 94
                6**************************.***************4.44.69*********97 PP

  == domain 2  score: 24.4 bits;  conditional E-value: 3e-08
   EF-hand_9   3 vFevcDtqktGrVpvsrlidyLravtaqdpeeseLeelakelDPdgedasvdldtflrvmre 64 
                  F+++D +  G ++ ++l+ + +  +++  ++ eL e  +e+D  ++ +++ +++flr+m++
  EFC38333.1 109 AFRLFDEDDSGFITFANLKRVAKDLGEN-MTDEELREMIEEADRSNQ-GQISKEDFLRIMKK 168
                 5**************************5.56779*************.************96 PP

>> SurA_N_3  SurA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.4   6.3e-05     0.059      81     148 ..      38     102 ..       8     114 .. 0.76
   2 !   13.8   0.5     4e-05     0.038      91     142 ..     120     170 ..      97     171 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 6.3e-05
    SurA_N_3  81 lglrqqvldqlidealllqeakklglsvsdeevakeiasipaFqedGkFdkerYkqlLaangltpeef 148
                   l ++  +  id + l+ +++ lg++ ++ee++k+i+ i+  + +Gk d + + ql+ a+ +++++ 
  EFC38333.1  38 FDLFDMDGSGKIDAKELKVAMRALGFEPKKEEIKKMISGID--NGSGKIDFNDFLQLMTAK-MSEKDS 102
                 5555555677899***************************9..678*********998875.444444 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 4e-05
    SurA_N_3  91 lidealllqeakklglsvsdeevakeiasipaFq.edGkFdkerYkqlLaang 142
                  i+ a l+  ak+lg +++dee++++i++ +  + ++G+ +ke + +++++++
  EFC38333.1 120 FITFANLKRVAKDLGENMTDEELREMIEEAD--RsNQGQISKEDFLRIMKKTN 170
                 5677789999*****************9888..5469***********99877 PP

>> Dockerin_1  Dockerin type I domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0     0.009       8.5      24      52 ..      28      56 ..      14      62 .. 0.78
   2 ?    3.4   0.0     0.095        90      40      54 ..      79      93 ..      77     105 .. 0.83
   3 !    6.9   0.1    0.0073       6.9       7      56 ..     118     168 ..     112     170 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.009
                SSEBTTSCCCHGGGSTT-SSCESHHHHHH CS
  Dockerin_1 24 qregqssssngkaaDvNgDGrvnalDall 52
                ++++q+ ++  + +D++g G+++a  + +
  EFC38333.1 28 DEQRQEIKEAFDLFDMDGSGKIDAKELKV 56
                55667777788889*********987765 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.095
                T-SSCESHHHHHHHH CS
  Dockerin_1 40 NgDGrvnalDallvi 54
                Ng G+++  D+l+++
  EFC38333.1 79 NGSGKIDFNDFLQLM 93
                777888888888775 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0073
                 SSC-SHHHHHHHHHHCT.SSEBTTSCCCHGGGSTT-SSCESHHHHHHHHHH CS
  Dockerin_1   7 DgkVnalDalliinyln.qregqssssngkaaDvNgDGrvnalDallviny 56 
                 +g ++   + ++ + l  + ++++  ++ + aD ++ G++++ D+l+++++
  EFC38333.1 118 SGFITFANLKRVAKDLGeNMTDEELREMIEEADRSNQGQISKEDFLRIMKK 168
                 5555555556666666655566777788999***************99875 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.2   8.9e-05     0.084      40      71 ..      29      60 ..       8      74 .. 0.80
   2 ?    2.6   0.1      0.13   1.3e+02      51      69 ..      74      93 ..      64      99 .. 0.77
   3 ?    4.0   0.3     0.052        49       9      70 ..     106     167 ..      97     170 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 8.9e-05
   EF-hand_4 40 leedklekiwdladidedgkldfeefciamrl 71
                 + +++++ +dl d+d  gk+d +e+ +amr 
  EFC38333.1 29 EQRQEIKEAFDLFDMDGSGKIDAKELKVAMRA 60
                456778899*********************95 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.13
   EF-hand_4 51 ladide.dgkldfeefciam 69
                ++ id+  gk+df++f   m
  EFC38333.1 74 ISGIDNgSGKIDFNDFLQLM 93
                577887369*******8777 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.052
   EF-hand_4   9 ikkyweifsglkpednkltgdkvapvlkn..skleedklekiwdladidedgkldfeefciamr 70 
                 i k + +f    +++  +t  ++  v k+   ++++++l ++ + ad  + g++  e+f  +m+
  EFC38333.1 106 IMKAFRLFDE--DDSGFITFANLKRVAKDlgENMTDEELREMIEEADRSNQGQISKEDFLRIMK 167
                 5555555543..33345555555555554225789999*********************99887 PP

>> FlgD  Flagellar hook capping protein - N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.9   4.4e-05     0.041      11      43 ..      14     101 ..       5     103 .. 0.72
   2 ?    2.6   0.0      0.18   1.7e+02      18      35 ..     149     166 ..     132     169 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 4.4e-05
        FlgD  11 aaeasrqt.......................................................sdksegeltqddFLkLLtaqLknQD 43 
                 a+++++q+                                                        d+ +g+++++dFL+L+ta ++  D
  EFC38333.1  14 ATSSNKQKvqieltdeqrqeikeafdlfdmdgsgkidakelkvamralgfepkkeeikkmisgIDNGSGKIDFNDFLQLMTAKMSEKD 101
                 44444444555666666666777777777777777777777777777777777777777777789999****************9877 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.18
        FlgD  18 tsdksegeltqddFLkLL 35 
                  +++++g+++++dFL+++
  EFC38333.1 149 ADRSNQGQISKEDFLRIM 166
                 56778999*******987 PP

>> SurA_N_2  SurA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.6    0.0062       5.8      94     124 ..      49      79 ..      12     100 .. 0.77
   2 !    9.7   0.3   0.00078      0.73      94     142 ..     121     163 ..      83     166 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0062
    SurA_N_2  94 vseklleqeaeklGltvsdeelqdaiqgnpa 124
                 ++ k l+ +++ lG++  +ee++++i+g+ +
  EFC38333.1  49 IDAKELKVAMRALGFEPKKEEIKKMISGIDN 79 
                 7777889999999***********9999555 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00078
    SurA_N_2  94 vseklleqeaeklGltvsdeelqdaiqgnpaikqsFqpetGkFdkeklk 142
                 ++ + l+  a++lG +++deel+++i++          ++G+++ke + 
  EFC38333.1 121 ITFANLKRVAKDLGENMTDEELREMIEEADR------SNQGQISKEDFL 163
                 566678899******************9766......367888877766 PP

>> EF-hand_14  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.1    0.0028       2.6       6      49 ..      38      81 ..      35     109 .. 0.84
   2 !    7.1   0.3    0.0073       6.9       6      53 ..     110     157 ..     103     171 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0028
  EF-hand_14  6 fdlfkdeetdklsvakllkaLaetGirkdDpRLkellkklkkve 49
                fdlf++++++k+  ++l  a+++ G + +   +k++++ + + +
  EFC38333.1 38 FDLFDMDGSGKIDAKELKVAMRALGFEPKKEEIKKMISGIDNGS 81
                9*************************999999999998887755 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0073
  EF-hand_14   6 fdlfkdeetdklsvakllkaLaetGirkdDpRLkellkklkkvekeks 53 
                 f lf++++++ + +a+l ++ ++ G + +D  L+e++++    ++ + 
  EFC38333.1 110 FRLFDEDDSGFITFANLKRVAKDLGENMTDEELREMIEEADRSNQGQI 157
                 899999999***************************998777766654 PP

>> DUF3911  Protein of unknown function (DUF3911)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.4    0.0035       3.3       4      33 ..      22      51 ..      19      94 .. 0.75
   2 ?   -0.6   0.0       1.6   1.5e+03      10      37 ..      67      92 ..      58     104 .. 0.59
   3 ?    7.5   0.1    0.0045       4.3       8      40 ..     101     132 ..      93     154 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0035
     DUF3911  4 vqikGtrkevvemlqlfdlmdtkGfckfkn 33
                vqi+ t ++  e+   fdl d  G  k + 
  EFC38333.1 22 VQIELTDEQRQEIKEAFDLFDMDGSGKIDA 51
                999999888888888888888888877764 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.6
     DUF3911 10 rkevvemlqlfdlmdtkGfckfknyvev 37
                ++e+ +m+   d     G   f++++++
  EFC38333.1 67 KEEIKKMISGIDN--GSGKIDFNDFLQL 92
                5566666655553..4455666666554 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0045
     DUF3911   8 GtrkevvemlqlfdlmdtkGfckfknyvevean 40 
                     e+++ ++lfd  d  Gf  f n   v  +
  EFC38333.1 101 DSHAEIMKAFRLFDE-DDSGFITFANLKRVAKD 132
                 5678**********8.557*****998877654 PP

>> SCF  Stem cell factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.4   4.6e-05     0.043      69     148 ..      89     169 ..      82     171 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 4.6e-05
         SCF  69 wlhlmvpelsk..sltnlldkfseiseslsnysiidklvkiiddlvecleedknknfvkknlklyeeksfipeeffrlfnrs 148
                 +l+lm +++s+  s  ++++ f  + e  s +    +l+++ +dl e +++++ ++++++  +  +++++  e+f+r+++++
  EFC38333.1  89 FLQLMTAKMSEkdSHAEIMKAFRLFDEDDSGFITFANLKRVAKDLGENMTDEELREMIEEA-DRSNQGQISKEDFLRIMKKT 169
                 578899999854488999**************************************77665.55678999*******99876 PP

>> EFhand_Ca_insen  Ca2+ insensitive EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       3.3   3.1e+03      51      59 ..      31      39 ..      23      60 .. 0.71
   2 ?   -0.4   0.0       1.4   1.3e+03      52      67 ..      78      93 ..      65      95 .. 0.76
   3 ?    9.9   0.1   0.00079      0.74       2      29 ..     100     128 ..      99     169 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3.3
                     ..S-TTEEE CS
  EFhand_Ca_insen 51 gdavekayD 59
                      +++++a+D
       EFC38333.1 31 RQEIKEAFD 39
                     445555555 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.4
                     .S-TTEEECCCHTTTT CS
  EFhand_Ca_insen 52 davekayDYvsFleal 67
                     d+ +++ D+++Fl+ +
       EFC38333.1 78 DNGSGKIDFNDFLQLM 93
                     4567889*****9865 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00079
                      -STHHHHHCHHHHH.CTTSSSEEHHHHHH CS
  EFhand_Ca_insen   2 vdsaeqveeaFral.aggKpYvTeedLrr 29 
                       ds  ++++aFr   +++  ++T  +L+r
       EFC38333.1 100 KDSHAEIMKAFRLFdEDDSGFITFANLKR 128
                      68999*********99999****999986 PP

>> Caleosin  Caleosin related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0     0.016        15       6      36 ..      34      64 ..      29      75 .. 0.87
   2 ?   -0.5   0.0       1.1     1e+03     104     133 ..      79     107 ..      64     112 .. 0.72
   3 ?    3.4   0.1     0.071        67       8      37 ..     108     137 ..     101     139 .. 0.82
   4 ?    0.1   0.0      0.68   6.5e+02      92     121 ..     139     168 ..     134     171 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.016
    Caleosin  6 LqqHvaFfDrdkdGiiypldtyrgfralgfn 36
                +++ ++ fD d  G i   +   ++ralgf+
  EFC38333.1 34 IKEAFDLFDMDGSGKIDAKELKVAMRALGFE 64
                5566788**********************97 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.1
    Caleosin 104 kekkdaltlkevlellkgqrealDlfgwla 133
                 +  ++++ ++++l+l+++++  +D  + ++
  EFC38333.1  79 NG-SGKIDFNDFLQLMTAKMSEKDSHAEIM 107
                 33.678899999999999998888777665 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.071
    Caleosin   8 qHvaFfDrdkdGiiypldtyrgfralgfnv 37 
                 + +  fD+d+ G+i++ +  r  ++lg n+
  EFC38333.1 108 KAFRLFDEDDSGFITFANLKRVAKDLGENM 137
                 55678***********99999999998776 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.68
    Caleosin  92 pqkfeeifskyakekkdaltlkevlellkg 121
                  +++ e+ ++ +++++++++ +++l+++k+
  EFC38333.1 139 DEELREMIEEADRSNQGQISKEDFLRIMKK 168
                 567778888888888899998888888876 PP

>> DUF4093  Domain of unknown function (DUF4093)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.48   4.5e+02      58      75 ..      47      64 ..      12      74 .. 0.66
   2 ?    0.1   0.0       1.2   1.1e+03       9      19 ..      67      77 ..      49     120 .. 0.61
   3 ?    9.1   0.1    0.0018       1.7       5      35 ..     135     164 ..     132     166 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.48
     DUF4093 58 gyangkqllkrLnmfkit 75
                g++++k+l+ ++++++++
  EFC38333.1 47 GKIDAKELKVAMRALGFE 64
                566777777777777764 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 1.2
     DUF4093  9 pealreaLaev 19
                +e+++++++ +
  EFC38333.1 67 KEEIKKMISGI 77
                34444444444 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.0018
     DUF4093   5 EhaspealreaLaeveeeekekeitkedLle 35 
                 E++++e+lre+++e+ + +++ +i+ked+l+
  EFC38333.1 135 ENMTDEELREMIEEA-DRSNQGQISKEDFLR 164
                 99*************.4666777*****986 PP

>> DUF3008  Protein of unknwon function (DUF3008)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       2.9   2.8e+03      19      45 ..      47      73 ..      46      79 .. 0.67
   2 ?   -2.0   0.2       4.4   4.2e+03      33      41 ..      93     101 ..      91     104 .. 0.80
   3 ?   10.4   0.0   0.00061      0.57      24      46 ..     124     146 ..     118     155 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 2.9
     DUF3008 19 GetkkseLkgaSksMyesMsekeLeel 45
                G+ +++eLk a + +     ++e++++
  EFC38333.1 47 GKIDAKELKVAMRALGFEPKKEEIKKM 73
                667788888887766555555555555 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 4.4
     DUF3008  33 MyesMseke 41 
                 M   Msek+
  EFC38333.1  93 MTAKMSEKD 101
                 888899986 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00061
     DUF3008  24 seLkgaSksMyesMsekeLeelA 46 
                  +Lk  +k++ e M+++eL+e+ 
  EFC38333.1 124 ANLKRVAKDLGENMTDEELREMI 146
                 589******************96 PP

>> SRI  SRI (Set2 Rpb1 interacting) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.35   3.3e+02      55      70 ..      20      36 ..       2      41 .. 0.69
   2 ?   -2.6   0.1       6.8   6.4e+03      29      33 ..      67      71 ..      48      76 .. 0.51
   3 ?    8.9   0.1    0.0018       1.7      30      53 ..     124     147 ..      94     168 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.35
         SRI 55 dppk.elseekkkkike 70
                ++++ el++e+++ ike
  EFC38333.1 20 QKVQiELTDEQRQEIKE 36
                2222479*****99997 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 6.8
         SRI 29 kedfK 33
                ke++K
  EFC38333.1 67 KEEIK 71
                34444 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0018
         SRI  30 edfKklakeltkklvekElkkdks 53 
                  ++K++ak+l + +++ El++  +
  EFC38333.1 124 ANLKRVAKDLGENMTDEELREMIE 147
                 689*****************9663 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1167  (0.0650901); expected 358.6 (0.02)
Passed bias filter:                      652  (0.0363657); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.57u 0.35s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1014.00
//
Query:       EFC38334.1  [L=154]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00079   19.5   0.0       0.18   12.2   0.0    2.6  2  PPR       PPR repeat
     0.0016   18.5   0.3     0.0035   17.4   0.1    1.7  2  PPR_3     Pentatricopeptide repeat domain
  ------ inclusion threshold ------
      0.012   15.7   0.1       0.89    9.9   0.0    2.7  2  TPR_8     Tetratricopeptide repeat
       0.03   14.5   0.2       0.14   12.4   0.0    2.0  2  PPR_2     PPR repeat family
      0.063   13.8   0.1        0.2   12.2   0.0    1.8  2  TPR_19    Tetratricopeptide repeat
      0.082   13.6   0.2         31    5.5   0.0    2.7  3  TPR_6     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.014        43       7      25 ..      79      97 ..      78     100 .. 0.91
   2 !   12.2   0.0   5.9e-05      0.18       2      26 ..     113     137 ..     112     140 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.014
         PPR  7 IsgycknGkleeAlelfke 25
                I+gy+   k  eA++l+++
  EFC38334.1 79 IRGYALLKKEAEAEQLYNQ 97
                99***************97 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 5.9e-05
         PPR   2 tynslIsgycknGkleeAlelfkeM 26 
                  yn+++++y    + ++A ++f+++
  EFC38334.1 113 HYNAILNVYINTQNTDKASKIFRQI 137
                 7*********************987 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.1   6.2e+03      24      36 ..      81      93 ..      79     103 .. 0.58
   2 !   17.4   0.1   1.2e-06    0.0035      15      41 ..     111     137 ..     105     140 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.1
       PPR_3 24 ayanagnkklale 36
                +ya+ +++  a++
  EFC38334.1 81 GYALLKKEAEAEQ 93
                5566666665555 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 1.2e-06
       PPR_3  15 vvtYthLLtayanagnkklalevlerm 41 
                 ++ Y+++L++y+n++n + a++++ ++
  EFC38334.1 111 IYHYNAILNVYINTQNTDKASKIFRQI 137
                 89**********************876 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1     0.066     2e+02      11      29 ..      82     100 ..      82     104 .. 0.86
   2 ?    9.9   0.0    0.0003      0.89       4      26 ..     114     136 ..     114     140 .. 0.94

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.066
                 HHHTT-HHHHHHHHHHHHH CS
       TPR_8  11 ylklgdyeeAkeyyekale 29 
                 y  l++  eA++ y++ ++
  EFC38334.1  82 YALLKKEAEAEQLYNQFID 100
                 667999*********9876 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0003
                 HHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyek 26 
                 y+ + ++y+++++ ++A + +++
  EFC38334.1 114 YNAILNVYINTQNTDKASKIFRQ 136
                 88999****************97 PP

>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.75   2.2e+03      10      28 ..      79      97 ..      78      99 .. 0.71
   2 ?   12.4   0.0   4.6e-05      0.14       5      28 ..     113     136 ..     111     139 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.75
       PPR_2 10 IsglckkgkveeAfklfne 28
                I g++  +k  eA +l+n+
  EFC38334.1 79 IRGYALLKKEAEAEQLYNQ 97
                5666655566699999986 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 4.6e-05
       PPR_2   5 tyNtlIsglckkgkveeAfklfne 28 
                  yN++++ + +  + ++A k+f +
  EFC38334.1 113 HYNAILNVYINTQNTDKASKIFRQ 136
                 6*********************87 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.45   1.4e+03       4      49 ..      51      96 ..      48     106 .. 0.58
   2 ?   12.2   0.0   6.5e-05       0.2      32      66 ..     118     150 ..      86     151 .. 0.67

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.45
      TPR_19  4 egdyaeAlalleqalqedpk..naearllLAeallalgqldeAealLd 49
                +g+ ae +++  +  q d k  + +a+  +++ +  l+  +eAe+l +
  EFC38334.1 51 QGKSAEVISIINK-DQLDGKitYKNAWR-YIRGYALLKKEAEAEQLYN 96
                5555555555555.44444444555555.5666666666677776655 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 6.5e-05
      TPR_19  32 AeallalgqldeAealLdalpeedpddaryasLlA 66 
                  ++++++ ++d+A ++  ++p+  ++  +   LlA
  EFC38334.1 118 LNVYINTQNTDKASKIFRQIPKIPKK--AFEELLA 150
                 599******************98877..6666666 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1     0.014        42       8      28 ..      82     100 ..      75     105 .. 0.75
   2 ?    5.5   0.0      0.01        31      10      26 ..     121     137 ..     119     140 .. 0.85
   3 ?   -2.8   0.0       4.7   1.4e+04      21      28 ..     143     150 ..     142     151 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.014
                 HHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   8 lsyrklgdtdkAlealerlik 28 
                 +    l++ ++A ++++++i+
  EFC38334.1  82 Y--ALLKKEAEAEQLYNQFID 100
                 3..34568889********97 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.01
                 HHHHHHHHHHHHHHHHH CS
       TPR_6  10 yrklgdtdkAlealerl 26 
                 y+++++tdkA ++++++
  EFC38334.1 121 YINTQNTDKASKIFRQI 137
                 88956**********97 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 4.7
                 HHHHHHHH CS
       TPR_6  21 ealerlik 28 
                 +a+e+l+ 
  EFC38334.1 143 KAFEELLA 150
                 79999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       897  (0.0500307); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 885.94
//
Query:       EFC38335.1  [L=506]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.9e-28   96.2  27.9    2.3e-07   30.9   0.3    6.0  6  FF        FF domain


Domain annotation for each model (and alignments):
>> FF  FF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.1   2.1e-09   3.8e-05       6      51 .]     114     158 ..     109     158 .. 0.96
   2 !   30.9   0.3   1.3e-11   2.3e-07       1      49 [.     176     232 ..     176     234 .. 0.85
   3 !   21.1   2.2   1.5e-08   0.00027       3      39 ..     254     295 ..     252     304 .. 0.86
   4 ?   -2.5   0.2      0.34   6.1e+03      41      51 .]     320     330 ..     313     330 .. 0.83
   5 !   20.3   0.0   2.6e-08   0.00047       6      40 ..     334     371 ..     331     377 .. 0.85
   6 !   16.7   1.0   3.5e-07    0.0063       2      40 ..     414     452 ..     413     462 .. 0.88

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 2.1e-09
                 HHHHHHHCSSS-TTSSHHHHHHHCTTSCCCHHGTSHHHHHHHHHHH CS
          FF   6 FkeLLkehkeitpkstWseikkilenDpRYlalldkseReelFedy 51 
                 Fk++L+++k +  +  Ws ++k+ +nD+R + +    +R+++F +y
  EFC38335.1 114 FKKMLDDCK-VQIDDDWSRAMKRVGNDSRVKIISRIQDRKDIFHQY 158
                 *********.9999*****************************987 PP

  == domain 2  score: 30.9 bits;  conditional E-value: 1.3e-11
                 CCHHHHHHHHHHCS....SS-TTS........SHHHHHHHCTTSCCCHHGTSHHHHHHHHH CS
          FF   1 kareaFkeLLkehk....eitpks........tWseikkilenDpRYlalldkseReelFe 49 
                 k re+F  +L e+k    +    s        t++++++++enD R+l+++++ +R++ F 
  EFC38335.1 176 KLREDFLSMLAELKstpiF----SqpkaylstTYQQVLPKIENDHRFLNVESEDDRLDYFY 232
                 579***********66543....244558888**************************995 PP

  == domain 3  score: 21.1 bits;  conditional E-value: 1.5e-08
                 HHHHHHHHHHCS...SS-TTSSHHHHHHHCTTSCCCHHG..T CS
          FF   3 reaFkeLLkehk...eitpkstWseikkilenDpRYlal..l 39 
                 +  FkeLL  +k    i++++ W+ i+++++++++Y+al  +
  EFC38335.1 254 KIRFKELLIRKKeqgLISYRTLWRHIREKIQSEEEYKALdyC 295
                 556************************************443 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 0.34
                 HHHHHHHHHHH CS
          FF  41 kseReelFedy 51 
                  +eRe+l++++
  EFC38335.1 320 REERERLIKQH 330
                 58999999887 PP

  == domain 5  score: 20.3 bits;  conditional E-value: 2.6e-08
                 HHHHHHHCS...SS-TTSSHHHHHHHCTTSCCCHHGTS CS
          FF   6 FkeLLkehk...eitpkstWseikkilenDpRYlalld 40 
                 +  LL+++    +++  s+W+e+k+i+e ++RY a+ +
  EFC38335.1 334 YWDLLSDLRksgKVNVLSSWKEVKPIIETEDRYQAIAN 371
                 567888888778899999*****************944 PP

  == domain 6  score: 16.7 bits;  conditional E-value: 3.5e-07
                 CHHHHHHHHHHCS.SS-TTSSHHHHHHHCTTSCCCHHGTS CS
          FF   2 areaFkeLLkehk.eitpkstWseikkilenDpRYlalld 40 
                  ++ F++L k++   i+ +s ++e+k+++e+D+R   + +
  EFC38335.1 414 DKKTFRKLIKDLDiVIDDTSNFEEFKSKIEKDDRVSSI-S 452
                 5899*********9********************9988.3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (506 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1929  (0.107591); expected 358.6 (0.02)
Passed bias filter:                      435  (0.0242624); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 2890.31
//
Query:       EFC38336.1  [L=548]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.2e-18   65.7  13.5    0.00066   20.4   0.5    7.8  7  WD40         WD domain, G-beta repeat
    0.00016   21.7   0.0       0.14   12.2   0.0    2.9  2  BBS2_Mid     Ciliary BBSome complex subunit 2, middle region
    0.00018   21.8   0.7       0.11   12.8   0.1    4.5  4  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.5   1.1e-07   0.00066       8      38 .]     109     154 ..      79     154 .. 0.86
   2 !   13.2   0.0   2.1e-05      0.12       3      37 ..     161     198 ..     159     199 .. 0.80
   3 !    6.9   0.2    0.0021        13       2      38 .]     202     240 ..     201     240 .. 0.71
   4 ?    4.4   0.0     0.013        77      13      38 .]     266     292 ..     249     292 .. 0.67
   5 ?    4.1   0.0     0.016        96       6      32 ..     321     345 ..     316     351 .. 0.73
   6 !   15.5   0.1     4e-06     0.024       6      38 .]     360     396 ..     356     396 .. 0.92
   7 ?    2.9   0.0     0.037   2.2e+02       8      36 ..     407     437 ..     400     439 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.1e-07
                 ESS.SSEEEEEEETTSSE..............EEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgaw..............lasGsdDgtvriWd 38 
                  GH ++v+s+ + p  +               l+sGsdD+++ iWd
  EFC38336.1 109 NGHrGCVNSVNWAPAEDVlksncyggvdlnnlLISGSDDCHINIWD 154
                 399888****655555559999999999999889***********9 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 2.1e-05
                 EEEEEESS.SSEEEEEEETTSSE..EEEEETTSEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgaw..lasGsdDgtvriW 37 
                 ++r+ t H +++ ++++ p+ ++  ++s+  Dg++ i+
  EFC38336.1 161 LQRVPTPHtGNIFCVKWFPNTNLstFISSAADGKIGIY 198
                 57788899777************98556656**99776 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0021
                 EEEEEEESSSS.EEEEE..EETTSSEEEEE.ETTSEEEEEE CS
        WD40   2 qclrtltGHss.vtsla..fspdgawlasG.sdDgtvriWd 38 
                 +++++++ H++ v+ ++  + ++  ++  + s Dg+++++d
  EFC38336.1 202 KHTQSIKEHNGmVHRVCieNGSSDIFI--SiSQDGSCKLFD 240
                 67788999*888887776255555554..4488******98 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.013
                 EEEEE..EETTSSEEEEEETTSEEEEEE CS
        WD40  13 vtsla..fspdgawlasGsdDgtvriWd 38 
                 ++s++    + + +++ G+dD+ vr++d
  EFC38336.1 266 INSIDmnPLDVNEFIL-GCDDQYVRLFD 292
                 5666544333345588.999******98 PP

  == domain 5  score: 4.1 bits;  conditional E-value: 0.016
                 EEESSSSEEEEEEETTSSEEEEE.ETTS CS
        WD40   6 tltGHssvtslafspdgawlasG.sdDg 32 
                  + +H  vt+++f+++g+ +++  s   
  EFC38336.1 321 LFPTH--VTGVRFNKHGNEILATyS-GD 345
                 57789..***********9886533.44 PP

  == domain 6  score: 15.5 bits;  conditional E-value: 4e-06
                 EEESSSSEEEEE....EETTSSEEEEEETTSEEEEEE CS
        WD40   6 tltGHssvtsla....fspdgawlasGsdDgtvriWd 38 
                 ++ GH++++ ++    f  d+ +++sGsd g+v +Wd
  EFC38336.1 360 KYNGHCNIRTVKevnfFGEDSEFVISGSDCGNVFVWD 396
                 689**8899999999*********************9 PP

  == domain 7  score: 2.9 bits;  conditional E-value: 0.037
                 ESSSS.EEEEEEETTSSEE.EEEETTSEEEE CS
        WD40   8 tGHss.vtslafspdgawl.asGsdDgtvri 36 
                 +G ++ v++l+ +p+ + + a+++   ++++
  EFC38336.1 407 KGDQHvVNCLSPHPYYPGVlATSGIEYNIKL 437
                 5555546***999999886245665666655 PP

>> BBS2_Mid  Ciliary BBSome complex subunit 2, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   2.4e-05      0.14      12      89 ..     138     222 ..     131     239 .. 0.71
   2 !    6.3   0.0    0.0016       9.9      11      45 ..     275     310 ..     266     322 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.4e-05
    BBS2_Mid  12 eneLvvgsddfeirvfkee..elvaeite..tekvvslarleker...fayaleNGtvgvyekkerlWrvksknevvalaaydin 89 
                 +n L+ gsdd +i +++ +  + ++ + +  t ++ +++   +++   f+ + + G +g+y++ ++  ++k++n +v   +++  
  EFC38336.1 138 NNLLISGSDDCHINIWDANksKCLQRVPTphTGNIFCVKWFPNTNlstFISSAADGKIGIYRNGKHTQSIKEHNGMVHRVCIENG 222
                 4678889********99872234444443114455555555555455599***********************999988877655 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0016
    BBS2_Mid  11 geneLvvgsddfeirvfkeeelva.eitetekvvsl 45 
                 + ne + g dd+ +r+f++ ++++ e ++t  +++l
  EFC38336.1 275 DVNEFILGCDDQYVRLFDRRRILNnEPRNTYCPTNL 310
                 579***************999875145555555555 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.1   1.9e-05      0.11      51      89 ..     139     177 ..      89     180 .. 0.92
   2 ?   -1.4   0.0      0.49   2.9e+03      35      68 ..     208     242 ..     188     255 .. 0.60
   3 ?   -0.8   0.0      0.33     2e+03      40      67 ..     325     352 ..     323     364 .. 0.86
   4 ?   -0.2   0.0      0.21   1.3e+03      41      87 ..     370     416 ..     362     417 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.9e-05
  ANAPC4_WD40  51 klLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                  +lL  + +d ++++ da++ k+++ +++ ++ ++ c++W
   EFC38336.1 139 NLLISGSDDCHINIWDANKSKCLQRVPTPHTGNIFCVKW 177
                  7899999**********************999******* PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.49
  ANAPC4_WD40  35 dkedsevrsLaWkp.dgklLavaysdgevrlldae 68 
                  +++++ v+ ++ ++ +  ++    +dg+++l+d  
   EFC38336.1 208 KEHNGMVHRVCIENgSSDIFISISQDGSCKLFDLR 242
                  45555555555543134455566678888888765 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.33
  ANAPC4_WD40  40 evrsLaWkpdgklLavaysdgevrllda 67 
                  +v+++++++ g+ +   ys  ++ l+d 
   EFC38336.1 325 HVTGVRFNKHGNEILATYSGDNIYLFDK 352
                  699999****999999999988888875 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.21
  ANAPC4_WD40  41 vrsLaWkpdg.klLavaysdgevrlldaesgkvvhslsvksekavtcl 87 
                  v+++++  ++ ++   + + g+v + d ++g +v+ ++ +++  v+cl
   EFC38336.1 370 VKEVNFFGEDsEFVISGSDCGNVFVWDKKTGCIVNIVKGDQH-VVNCL 416
                  5666655544055555555689**********9999998888.58887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (548 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 3351.23
//
Query:       EFC38337.1  [L=387]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.4e-20   72.6   1.4    6.3e-20   71.7   1.4    1.5  1  AAA-ATPase_like  Predicted AAA-ATPase
  ------ inclusion threshold ------
       0.21   11.5   1.9        3.6    7.4   0.8    2.3  2  Coagulin         Coagulin


Domain annotation for each model (and alignments):
>> AAA-ATPase_like  Predicted AAA-ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.7   1.4     7e-24   6.3e-20     111     278 ..       4     169 ..       1     171 [. 0.88

  Alignments for each domain:
  == domain 1  score: 71.7 bits;  conditional E-value: 7e-24
  AAA-ATPase_like 111 kefgkkkeekslakrlkelieraaektgkkvvvLiDEYDkpilealeeeelaeelreflrefykvlkk...adeylkfvfltGvskvtkdsifS 201
                      ++f+k  + +  +++l+ li  ++++ ++kvv+LiDEY++p+l  ++++   +e+ +++   +  lk+     e +++v+  Gv  +  ++  S
       EFC38337.1   4 SQFKKILSGNCDESSLSLLIGLLYRHFNSKVVLLIDEYETPVLAHINST-FSKEVLDLFFGMFIFLKNdefILEKIQTVLFSGVILLKDKGYLS 96 
                      567777778888999999****************************998.9999999999999999995556678899**************** PP

  AAA-ATPase_like 202 glnnlkdislde..kysallGfteeeveellkeeleelalkeatveelieelkewYdgYsFaeeseesvyNpfsvlnll 278
                      g+nnl  +sld+   +s+ +G+te+e+ ++l++  +      ++v   +++lk+wY+gY  + ++ + ++N +s+  ++
       EFC38337.1  97 GMNNLVAYSLDKdnYFSEDFGVTENELCQFLTTLRHG-----EDVSLELTKLKSWYNGYDVN-NTPKFLFNVWSLSCYF 169
                      **********986579***************999333.....35677899**********95.6667*******98887 PP

>> Coagulin  Coagulin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.014   1.2e+02     147     164 ..     100     117 ..      95     126 .. 0.84
   2 ?    7.4   0.8    0.0004       3.6      60     110 ..     333     380 ..     320     384 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.014
    Coagulin 147 rlvtydlekdvflcesvr 164
                  lv+y l+kd ++ e++ 
  EFC38337.1 100 NLVAYSLDKDNYFSEDFG 117
                 69*************986 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0004
    Coagulin  60 kyecrtvrsedsrcynffpfthfklecpvsvrdcepvfgytvanelrvivq 110
                   ec+ v  + s  y f+ +++    c  + ++c+ vf   + +e++ +++
  EFC38337.1 333 ELECKGVDEKYSIKYYFPKLEQ---YCSFTKSACKTVFPTFTNKEFKFVIE 380
                 579*****99999999987665...5999***********9*****99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (387 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 2528.77
//
Query:       EFC38338.1  [L=433]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.8e-19   68.0  15.8    1.9e-05   24.3   0.8    6.3  6  RCC1_2           Regulator of chromosome condensation (RCC1) 
    6.1e-18   65.2   0.3     0.0002   21.9   0.1    6.6  7  RCC1             Regulator of chromosome condensation (RCC1) 
     0.0044   16.8   1.2        4.8    7.1   0.0    3.6  4  Peptidase_C25_C  Peptidase family C25, C terminal ig-like dom


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.2   1.9e-05      0.12       7      27 ..     109     129 ..     103     132 .. 0.87
   2 !   13.9   0.0   5.7e-06     0.034       5      30 .]     164     189 ..     161     189 .. 0.95
   3 !   13.7   0.1   6.8e-06      0.04       6      30 .]     225     249 ..     220     249 .. 0.90
   4 !   24.3   0.8   3.1e-09   1.9e-05       2      30 .]     279     307 ..     278     307 .. 0.95
   5 !    9.0   0.1   0.00021       1.3       1      24 [.     342     365 ..     342     370 .. 0.93
   6 ?    0.7   0.0      0.08   4.8e+02       5      15 ..     393     403 ..     390     404 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.9e-05
      RCC1_2   7 GdyHscaLtedGeVlcWGsNs 27 
                  ++H ++Lt +++++++G+N+
  EFC38338.1 109 SSSHNLFLTYNNDIYGCGHNG 129
                 579*****************7 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 5.7e-06
      RCC1_2   5 saGdyHscaLtedGeVlcWGsNsdGQ 30 
                 s+G ++s+ +t+d+++++ G N +GQ
  EFC38338.1 164 SSGTDFSICITDDNKMFASGVNYSGQ 189
                 79***********************9 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 6.8e-06
      RCC1_2   6 aGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++d+ +++ t++G+++++G+ s+G+
  EFC38338.1 225 SNDNSTIFRTSEGKLYGFGNHSYGC 249
                 78999*******************8 PP

  == domain 4  score: 24.3 bits;  conditional E-value: 3.1e-09
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +s s+G ++ ca+te+++++++G N++ Q
  EFC38338.1 279 ISFSCGMFFVCAITESNHLYAFGYNNCHQ 307
                 7889***********************98 PP

  == domain 5  score: 9.0 bits;  conditional E-value: 0.00021
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWG 24 
                 V sv +G+y ++aL+ d++++ +G
  EFC38338.1 342 VSSVVCGGYSTFALSMDNKIYITG 365
                 789******************999 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.08
      RCC1_2   5 saGdyHscaLt 15 
                 s Gd+Hs +L+
  EFC38338.1 393 SNGDFHSAILV 403
                 559****9986 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.42   2.5e+03      32      43 ..      21      34 ..      15      41 .. 0.73
   2 ?   -1.9   0.0      0.92   5.5e+03      34      50 .]      98     116 ..      90     116 .. 0.79
   3 ?    4.3   0.0     0.011        65       4      50 .]     122     173 ..     119     173 .. 0.76
   4 !    7.5   0.0     0.001       6.1       3      21 ..     178     196 ..     176     212 .. 0.86
   5 !   21.1   0.1   5.8e-08   0.00035       1      50 []     236     291 ..     236     291 .. 0.77
   6 !   21.9   0.1   3.3e-08    0.0002       3      50 .]     296     355 ..     294     355 .. 0.85
   7 ?    0.5   0.0      0.16   9.4e+02      34      50 .]     386     402 ..     381     402 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.42
                GTTS..-EEEEEEE CS
        RCC1 32 lsgn..rvvkvacG 43
                l+++  +v+kv+c 
  EFC38338.1 21 LRRRkiNVTKVVCA 34
                4455789*****95 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.92
                 TS..-EEEEEEETTEEEEE CS
        RCC1  34 gn..rvvkvacGddhtval 50 
                 gn  +v ++ + ++h+++l
  EFC38338.1  98 GNeiPVRDIISSSSHNLFL 116
                 4456999999999**9986 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.011
                 EEEEE--GGGTTSSSS-......--EEEEEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1   4 VysWGrndyGqLGlgtt......esvlvPtkveglsgn..rvvkvacGddhtval 50 
                 +y++G n + q+ + ++      e+v   tk++ +++   +++ +++G d+++++
  EFC38338.1 122 IYGCGHNGRMQMYTNSKksfsdlEEV---TKLSIPNAGnpKFKLASSGTDFSICI 173
                 67777777777777666566666666...88888888789************997 PP

  == domain 4  score: 7.5 bits;  conditional E-value: 0.001
                 EEEEEE--GGGTTSSSS-- CS
        RCC1   3 rVysWGrndyGqLGlgtte 21 
                 + ++ G n  Gq+G+g+++
  EFC38338.1 178 KMFASGVNYSGQCGIGSSK 196
                 67999***********986 PP

  == domain 5  score: 21.1 bits;  conditional E-value: 5.8e-08
                 TTEEEEEE--GGGTTSSSS-...--EEEEEE-.GGGTTS...-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt...esvlvPtkv.eglsgn...rvvkvacGddhtval 50 
                 +G++y++G+++yG+ Glg +   e++ +  +v +g+++    + ++ +cG ++++a+
  EFC38338.1 236 EGKLYGFGNHSYGCFGLGEDierENHEI-CRVgSGSKEFmkeKCISFSCGMFFVCAI 291
                 7*******************97644433.3343333333667***********9997 PP

  == domain 6  score: 21.9 bits;  conditional E-value: 3.3e-08
                 EEEEEE--GGGTTSSSS---EEEEEE-......GGGTTS..........-EEEEEEETTEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesvlvPtkv......eglsgn..........rvvkvacGddhtval 50 
                 ++y++G n+ +qL  ++ ++v +P+k+      +    n           v++v+cG++ t+al
  EFC38338.1 296 HLYAFGYNNCHQLSAKDLHTVYTPVKInltdclS----NnasnipgysgLVSSVVCGGYSTFAL 355
                 69*************************7765552....134557888989999*********97 PP

  == domain 7  score: 0.5 bits;  conditional E-value: 0.16
                 TS-EEEEEEETTEEEEE CS
        RCC1  34 gnrvvkvacGddhtval 50 
                 ++  ++++ Gd+h++ l
  EFC38338.1 386 SKTPIQMSNGDFHSAIL 402
                 556789999*****975 PP

>> Peptidase_C25_C  Peptidase family C25, C terminal ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.53   3.2e+03      32      41 ..     116     125 ..     113     128 .. 0.88
   2 !    5.5   0.0    0.0026        15      30      51 ..     171     192 ..     156     199 .. 0.83
   3 ?   -0.6   0.0      0.21   1.3e+03      17      41 ..     219     242 ..     215     248 .. 0.85
   4 !    7.1   0.0    0.0008       4.8      21      42 ..     345     365 ..     340     381 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.53
                      EEETTEEEEE CS
  Peptidase_C25_C  32 lSannkllGs 41 
                      l++nn+++G 
       EFC38338.1 116 LTYNNDIYGC 125
                      899*****96 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0026
                      EEEEETTEEEEEEE-BTTEEEE CS
  Peptidase_C25_C  30 valSannkllGsaivasGqatl 51 
                      + ++++nk++ s++  sGq  +
       EFC38338.1 171 ICITDDNKMFASGVNYSGQCGI 192
                      579***************9766 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.21
                      SEEEEEESSTT-EEEEEETTEEEEE CS
  Peptidase_C25_C  17 nsievscdvdgalvalSannkllGs 41 
                      + ie++++ d++++  + ++kl+G 
       EFC38338.1 219 EIIEIHSN-DNSTIFRTSEGKLYGF 242
                      56899999.99**999*******95 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0008
                      EEESSTT-EEEEEETTEEEEEE CS
  Peptidase_C25_C  21 vscdvdgalvalSannkllGsa 42 
                      v c+  +++ alS++nk++ ++
       EFC38338.1 345 VVCG-GYSTFALSMDNKIYITG 365
                      7788.9************9665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (433 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       374  (0.0208601); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.26s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 2846.11
//
Query:       EFC38339.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-06   28.1   0.0    3.4e-06   27.2   0.0    1.5  1  Lipase_GDSL    GDSL-like Lipase/Acylhydrolase
    1.9e-06   28.4   0.0      3e-06   27.8   0.0    1.4  1  Lipase_GDSL_2  GDSL-like Lipase/Acylhydrolase family


Domain annotation for each model (and alignments):
>> Lipase_GDSL  GDSL-like Lipase/Acylhydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   0.0   3.8e-10   3.4e-06       2     200 .]     116     320 ..     115     320 .. 0.68

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 3.8e-10
                  EEEESHHHH..........TTTHHHHHHHCCCCEECCCTTC...............GCEEEEEEECTTHHHHHHHCCHECTTTECHHHHHCTTS.... CS
                  xxxxxxxxx..........xxxxxxxxxxxxxxxxxxxxxxx..............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.... RF
  Lipase_GDSL   2 vafGDSltd..........Gdgaatlntiqlktpknlnefdl..............aldrianignkgasdnelqqllnkyplkseqlkalhpd.... 71 
                   ++GDSl++          G++++t +  q  + k  +   l                +++a  + ++ +  + +  +   + +++ +  ++ d    
   EFC38339.1 116 EFLGDSLSCaygnlgkppcGYSVTTQDVHQSFVVKTAQY--LqadeyhvecysgkgVVRNYADPSSTSKDPYPVYYPR--TVANQNISNWNFTDyips 209
                  699******776666666666666666655555443333..2346677777777754444444444444444444444..777777777777778888 PP

                  EEEEE--CTCC-EECSSCTTTCEEHHHHHHHHHHHHHHHH.HHHH..TTEEEEEEE-SSTCHCTCCCCHCCHHHHHHHHHHHHHHHHHHHH....HCT CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxx RF
  Lipase_GDSL  72 lviislGtNDsnlgkkstdaakkeaeeyiknlreaikelk.eega..pkaivvlvsppglgpqeekdakklgekgnefvgeynqrlndlae....kdg 162
                  lv+i lG+ND+        a   + e+y+  + ++++ ++ +++a  p ++vvlv   g+ +              +  + y +r+++ a+    ++ 
   EFC38339.1 210 LVVITLGGNDF------STAPRPSYEQYYGGYINLLNFVYgKYLAkkPDLKVVLVC--GPLE-------------FDCWENYTERVSNQAApqfpQNS 286
                  ***********......778888888888877777776665555500556666663..3333.............234666666666666667779** PP

                  EEEECHHHHHHHTHCCGCHCHTSSSB-HHHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Lipase_GDSL 163 favvDlydelqglsgieqlkaDglHpsekgyeklaell 200
                  + ++ +++ l ++++i++ +    Hp+ +g ek+a+ll
   EFC38339.1 287 LYFLSMHNLLNQNTDIGCAS----HPNVQGDEKMAKLL 320
                  *************9999988....***********986 PP

>> Lipase_GDSL_2  GDSL-like Lipase/Acylhydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.8   0.0   3.3e-10     3e-06       1     129 [.     117     279 ..     117     315 .. 0.59

  Alignments for each domain:
  == domain 1  score: 27.8 bits;  conditional E-value: 3.3e-10
                    EEESHHHHTCTTB.........CCHCHHCCCCCCCHHHTT-EEEEE.EEHCCH-H............HHHHHHHH...........CTGGG-TSEE CS
  Lipase_GDSL_2   1 alGDSiTaGygad.........gggrsypaylarllaarlgldvvnnlgvsGatt..........allrllerlr...........dllrlkpdlv 66 
                    +lGDS+++ yg           ++++  +++   + a+ l++d++ +  +sG  +          + + ++ +++           + +++ p lv
     EFC38339.1 117 FLGDSLSCAYGNLgkppcgysvTTQDVHQSF-VVKTAQYLQADEYHVECYSGKGVvrnyadpsstSKDPYPVYYPrtvanqnisnwNFTDYIPSLV 211
                    79******99999888888888444444444.555555555555555556666553334333333233333333322223333444455666699* PP

                    EEE--CCCCCTT--HHHHHHH..HHHHHH....HHCCC...GEEE.CEEEEE-TTT-TTSTCCHHHHH CS
  Lipase_GDSL_2  67 tiliGtNDlgrgvpaaaaaandnleelid....alraaapgaril.vlgplpptpeaaadarelnavi 129
                    +i++G+ND+ + + ++  + + ++ +l++    +  a++p+ +++ v+gpl     +   +r +n+++
     EFC38339.1 212 VITLGGNDFSTAPRPSYEQYYGGYINLLNfvygKYLAKKPDLKVVlVCGPLEFDCWENYTERVSNQAA 279
                    ********988888887777675666666555788888*******43333333333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2240.21
//
Query:       EFC38340.1  [L=550]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.8e-23   80.6   0.4    1.2e-22   79.5   0.4    1.6  1  RWP-RK    RWP-RK domain


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5   0.4     7e-27   1.2e-22       2      49 .]       5      52 ..       4      52 .. 0.97

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 7e-27
      RWP-RK  2 ltleelqqyFslplkeAAksLgvskttLKricRelgIsRWPyRkiksl 49
                +++e++qqyF+lpl+eAA +Lg+++++LKr cR+lgI+RWPyR++ksl
  EFC38340.1  5 INKEQIQQYFHLPLEEAAIKLGCCSSVLKRTCRQLGIKRWPYRRMKSL 52
                899*******************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (550 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1394  (0.0777511); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.77u 0.38s 00:00:01.14 Elapsed: 00:00:00.57
# Mc/sec: 2892.55
//
Query:       EFC38341.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-11   44.6   0.4    2.2e-11   44.0   0.4    1.4  1  BTB       BTB/POZ domain
     0.0064   16.7   0.2      0.013   15.7   0.2    1.6  1  DUF3342   Domain of unknown function (DUF3342)


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.4   2.5e-15   2.2e-11       3     108 ..      53     160 ..      51     163 .. 0.89

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 2.5e-15
                 HHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST..TTTTCCCEEEEETTSGHH.HHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HH CS
         BTB   3 elresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk..eieessvseielddvepe.afealLefiYtgeleitseenleelLaaadllqipr 98 
                 +l++++   D+ ++vgd+ ++++hk +L + S yF +lf+s   ++ + +v +++++d e+  a + +++++Y  +++i+  + l  +++a ++ +i+ 
  EFC38341.1  53 KLFNHEPSHDLRILVGDQVTYYCHKTILESTSLYFTDLFKSSnwSDFDTDVYKLDVNDEESIiATDYIIRYCYDLQIDIE-PSHLIGVMKASHMHNIKP 150
                 678888999*********************************8866666666787777776438899************7.****************** PP

                 HHHHHHHHHH CS
         BTB  99 lkkaceeflk 108
                 l+++c+++l+
  EFC38341.1 151 LITLCSKKLE 160
                 ******9986 PP

>> DUF3342  Domain of unknown function (DUF3342)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.2   1.5e-06     0.013      14      96 ..      71     155 ..      65     178 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.5e-06
     DUF3342  14 rdfrCaqdlLetemrYfeeiikryiseaqrleeidirvnCdlsif..dWLmkyvkkkkrkltpenvvsillsssfLkmeeLvdea 96 
                  ++ C++ +Le+   Yf+++ k     +  ++  ++ vn + si   d++++y    + +++p+  + ++ +s++ ++++L+  +
  EFC38341.1  71 VTYYCHKTILESTSLYFTDLFKSSNWSDFDTDVYKLDVNDEESIIatDYIIRYCYDLQIDIEPSHLIGVMKASHMHNIKPLITLC 155
                 5899*****************997766666666777777777664339**********************999999999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       489  (0.0272742); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 1342.32
//
Query:       EFC38342.1  [L=938]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-10   41.3   0.8    2.8e-10   40.1   0.8    1.5  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.1   0.8   1.6e-14   2.8e-10       7     160 ..     682     839 ..     679     850 .. 0.89

  Alignments for each domain:
  == domain 1  score: 40.1 bits;  conditional E-value: 1.6e-14
  Guanylate_cyc   7 devtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevaveskeglk 101
                    +++tilF+++vgf +ls   +   ++ l+ ++++ + + ++e+++   ++iGd  ++v+++   + ++h  k+++ aL+++ ++e+++  +  +l+
     EFC38342.1 682 RNMTILFTELVGFSELSHGIHDDFLPCLMTNYFTIVSKAVKEEGGMITQFIGDRAVCVFNVYcLPLENHEIKACRAALKIMMNIENFNRIHLSDLQ 777
                    79******************9999************************************99778999999************************* PP

  Guanylate_cyc 102 vrvGihtG.pvvagviG.akkprydvwGntvnlAsrm..estgkagkiqvseetyellkeeqf 160
                    vr  i +   +++g  G +++++ +v+G +v +A  +      +++ki + e+ty+    e+f
     EFC38342.1 778 VRASITSDeNILCGNTGsQSRMNVTVIGSSVPIAKALlfLNKHVGKKILIHEKTYQKVV-ENF 839
                    *****8762699*****99*************998651155667899999999998766.555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (938 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1002  (0.0558871); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.84u 0.32s 00:00:01.15 Elapsed: 00:00:00.53
# Mc/sec: 5323.02
//
Query:       EFC38343.1  [L=2122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-17   62.3 158.1    2.3e-06   27.9   6.6   12.6 12  EGF_2     EGF-like domain
    6.5e-08   32.6   0.4    2.4e-07   30.8   0.4    2.0  1  Jacalin   Jacalin-like lectin domain
      2e-05   24.8   0.1    4.4e-05   23.7   0.1    1.5  1  Orf78     Orf78 (ac78)
    0.00043   20.2   0.1     0.0016   18.3   0.1    2.0  1  TMEM154   TMEM154 protein family
     0.0095   16.2   6.0     0.0095   16.2   6.0    9.9  9  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   1.7      0.12   4.4e+02      22      32 .]     597     607 ..     579     607 .. 0.90
   2 !   11.2   4.4   0.00011      0.38       5      26 ..     620     640 ..     616     645 .. 0.81
   3 !   19.7  10.8   2.4e-07   0.00084       6      32 .]     664     689 ..     659     689 .. 0.89
   4 !   13.7   9.3   1.7e-05     0.059       7      32 .]     705     729 ..     700     729 .. 0.86
   5 !   27.9   6.6   6.4e-10   2.3e-06       4      32 .]     740     768 ..     737     768 .. 0.91
   6 !   16.9   6.8   1.7e-06    0.0062       6      32 .]     782     807 ..     777     807 .. 0.88
   7 !    6.2  11.1    0.0039        14       6      32 .]     821     847 ..     812     847 .. 0.84
   8 ?    4.7   2.3     0.011        39      22      32 .]     849     859 ..     849     859 .. 0.96
   9 !   15.4   4.5   4.9e-06     0.018       7      32 .]     874     899 ..     869     899 .. 0.91
  10 ?    1.2   0.8      0.14   5.1e+02      22      32 .]     901     911 ..     901     911 .. 0.94
  11 !   15.6   8.0   4.3e-06     0.015       4      32 .]     923     950 ..     920     950 .. 0.87
  12 ?   -4.6   5.9         5   1.8e+04      18      32 .]     962     974 ..     952     974 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.12
       EGF_2  22 dCdsgyqGktC 32 
                 +C +gy+G++C
  EFC38343.1 597 SCANGYSGDDC 607
                 69********* PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00011
       EGF_2   5 deiCgghGtCvnqcGqCdCdsg 26 
                 ++ C+g+G C  ++ +C+C s+
  EFC38343.1 620 KLVCNGNGRCAGPN-NCSCMSS 640
                 789********888.8***554 PP

  == domain 3  score: 19.7 bits;  conditional E-value: 2.4e-07
       EGF_2   6 eiCgghGtC.vnqcGqCdCdsgyqGktC 32 
                  iC+g+G+C    +G C+C+ gy+G+ C
  EFC38343.1 664 AICSGRGSChY--NGTCSCEKGYYGNEC 689
                 58*******65..89************* PP

  == domain 4  score: 13.7 bits;  conditional E-value: 1.7e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +C++hG C +    C+C+ gy+G +C
  EFC38343.1 705 TCSNHGNCLDID-TCECNVGYTGRNC 729
                 7*******6445.8************ PP

  == domain 5  score: 27.9 bits;  conditional E-value: 6.4e-10
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + + iC+ghG+Cv++  +C+C++gy+G++C
  EFC38343.1 740 NtSGICSGHGSCVRPS-VCSCKTGYYGPKC 768
                 45789********899.************* PP

  == domain 6  score: 16.9 bits;  conditional E-value: 1.7e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+  G C++ + +C+C+ gy+G++C
  EFC38343.1 782 SVCSSKGGCIDYN-KCVCKEGYYGPNC 807
                 57*******8555.************* PP

  == domain 7  score: 6.2 bits;  conditional E-value: 0.0039
       EGF_2   6 eiCgghGtCvnqc.GqCdC.dsgyqGktC 32 
                 + C+g+G+C+  + ++C C  +  +G +C
  EFC38343.1 821 NVCSGNGQCI--GvNNCACtTPRSSGQSC 847
                 68********..5458***9888889999 PP

  == domain 8  score: 4.7 bits;  conditional E-value: 0.011
       EGF_2  22 dCdsgyqGktC 32 
                 +Cdsgy+G +C
  EFC38343.1 849 KCDSGYFGSHC 859
                 6********** PP

  == domain 9  score: 15.4 bits;  conditional E-value: 4.9e-06
       EGF_2   7 iCgghGtCvnqcGqCdC.dsgyqGktC 32 
                  C+g+G+C +++  C C +++  Gk C
  EFC38343.1 874 VCSGRGICKSLN-TCICeNDNINGKLC 899
                 6*******9888.9************9 PP

  == domain 10  score: 1.2 bits;  conditional E-value: 0.14
       EGF_2  22 dCdsgyqGktC 32 
                 +C +gy+G +C
  EFC38343.1 901 SCITGYYGEKC 911
                 59********* PP

  == domain 11  score: 15.6 bits;  conditional E-value: 4.3e-06
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++ C+ +G+C + + +C+C+s  +G +C
  EFC38343.1 923 NSSVCNYRGVCSSYN-NCVCNSRSYGTYC 950
                 5789*******9555.8************ PP

  == domain 12  score: -4.6 bits;  conditional E-value: 5
       EGF_2  18 cGqCdCdsgyqGktC 32 
                 cG  +C  +++G+ C
  EFC38343.1 962 CG--SCAGSHYGDEC 974
                 55..89********9 PP

>> Jacalin  Jacalin-like lectin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   0.4   6.7e-11   2.4e-07       8     127 ..     474     586 ..     469     591 .. 0.81

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 6.7e-11
                 S-CEECEEEEEEESSSEEEEEEEEEETTSEE-EEEEEEEETTBSEEEEEETTT--EEEEEEEEEEESSSEEEEEEEEEEETTS-EEEEEC.--SEEEEE CS
     Jacalin   8 eydgvrkvyvgqgedgiayikfeYvkaggkvegdehGkkgllgteefeidypdEyitsVegtydkvsvesevitsLtfkTnkgrtselfgtksgtkfsl 106
                 ++++v ++ +  ++ ++ + kf+Y +++    +     +  +++ +  +d  dEyi++ +  y+++ ++++++  ++fkTnk+ t+++   +++ kf+ 
  EFC38343.1 474 TTQKVSRIDILGDGYVY-CFKFTYTDGAI---KYFNEARCIGRVITAYLD-NDEYIKEMSHDYTTF-GSAQILLCISFKTNKQ-TINFLC-DNKVKFVE 564
                 66677777777777777.88999998433...333344444457788899.79***********86.669*************.888999.89****** PP

                 E-.SSEEEEEEEEEESSSEEEE CS
     Jacalin 107 ee.kgkkivGFhGragnllnal 127
                  + +g +++GF  ++g++++++
  EFC38343.1 565 YVpEGLEVIGFGVKSGYCIDSI 586
                 ********************98 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.1   1.2e-08   4.4e-05      29     101 ..    1992    2059 ..    1976    2061 .. 0.54

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 1.2e-08
       Orf78   29 ddndkaenkkekksaaeknditekesnaaekaqalnillisllavvcvlvllyviyYfvilrerqkssvkeps 101 
                  +++d+++n     ++ ++n+ ++ +sn++++a+a  il+ +ll++vc ++ + +++ f+i+re++k++++ p+
  EFC38343.1 1992 QNSDNNNN----GNNDNNNNNSNGNSNDSSAAAAVVILIPVLLCCVC-FITIPIVVGFIIVREKRKQQQNTPN 2059
                  22222222....22222233333333334455554555555555555.5666777889999**9999988776 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.1   4.5e-07    0.0016      24      93 ..    1988    2056 ..    1968    2063 .. 0.68

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 4.5e-07
     TMEM154   24 atsaasteseslkqeeakeslssaelsnesdqlelvlmiiiPlvllillllvviili.qkkkrkrsKddek 93  
                   ++++++ ++  ++++++++ +s   sn+s+  +  ++i+iP  l  + ++ + i++  +  r+++K++++
  EFC38343.1 1988 KSTTQNS-DNNNNGNNDNNNNNSNGNSNDSSAAAA-VVILIPVLLCCVCFITIPIVVgFIIVREKRKQQQN 2056
                  3455566.666667777777777777777776665.57889999988888877776623445666666543 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.3      0.44   1.6e+03      24      31 ..     598     605 ..     579     606 .. 0.67
   2 ?   -2.7   4.3       2.1   7.7e+03       6      22 ..     623     637 ..     617     638 .. 0.68
   3 !    7.3   7.3    0.0016       5.8       5      31 ..     662     687 ..     655     688 .. 0.83
   4 !   16.2   6.0   2.7e-06    0.0095       5      32 .]     704     728 ..     701     728 .. 0.89
   5 !   13.8   3.6   1.5e-05     0.055       5      31 ..     741     766 ..     738     767 .. 0.87
   6 !    7.8   3.7    0.0012       4.2       6      32 .]     784     806 ..     778     806 .. 0.81
   7 ?   -7.3  13.0         5   1.8e+04       3      30 ..     820     856 ..     818     858 .. 0.55
   8 ?    3.2   2.7     0.032   1.1e+02       5      25 ..     872     890 ..     869     898 .. 0.82
   9 ?   -3.9   2.8         5   1.8e+04       6      24 ..     927     941 ..     920     949 .. 0.64

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.44
                 ECTTEEST CS
         EGF  24 CpeGytGk 31 
                 C++Gy+G+
  EFC38343.1 598 CANGYSGD 605
                 77888776 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.1
                 STTT-EEEEETTTEEEE CS
         EGF   6 CsngGtCvdtgrggytC 22 
                 C+++G+C  ++ +  +C
  EFC38343.1 623 CNGNGRC-AGP-NNCSC 637
                 *******.555.44444 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0016
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                     Cs++G C ++g    tC C  Gy G+
  EFC38343.1 662 SvaiCSGRGSCHYNG----TCSCEKGYYGN 687
                 2556***********....*********97 PP

  == domain 4  score: 16.2 bits;  conditional E-value: 2.7e-06
                 T.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGkr 32 
                   Csn+G C+d      tC+C +GytG++
  EFC38343.1 704 GtCSNHGNCLDID----TCECNVGYTGRN 728
                 44***********....**********86 PP

  == domain 5  score: 13.8 bits;  conditional E-value: 1.5e-05
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                 +   Cs++G Cv+++     C C++Gy G+
  EFC38343.1 741 TsgiCSGHGSCVRPS----VCSCKTGYYGP 766
                 4456***********....*********97 PP

  == domain 6  score: 7.8 bits;  conditional E-value: 0.0012
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs  G C+d+     +C C+eGy G++
  EFC38343.1 784 CSSKGGCIDYN----KCVCKEGYYGPN 806
                 555555*****....**********86 PP

  == domain 7  score: -7.3 bits;  conditional E-value: 5
                 STTSTTT-EE..EEET......TTEEEEE.ECTTEES CS
         EGF   3 pnpCsngGtC..vdtg......rggytCi.CpeGytG 30 
                 pn Cs++G C  v++       + g +C+ C++Gy+G
  EFC38343.1 820 PNVCSGNGQCigVNNCacttprSSGQSCEkCDSGYFG 856
                 455*******554444444444555555335555665 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.032
                 T..STTT-EEEEETTTEEEEEEC CS
         EGF   5 p..CsngGtCvdtgrggytCiCp 25 
                 p  Cs++G+C ++     tCiC 
  EFC38343.1 872 PtvCSGRGICKSLN----TCICE 890
                 445*******8888....99997 PP

  == domain 9  score: -3.9 bits;  conditional E-value: 5
                 STTT-EEEEETTTEEEEEE CS
         EGF   6 CsngGtCvdtgrggytCiC 24 
                 C+ +G C ++     +C C
  EFC38343.1 927 CNYRGVCSSYN----NCVC 941
                 77777775554....5666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1126  (0.0628033); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.13u 0.36s 00:00:01.48 Elapsed: 00:00:00.54
# Mc/sec: 11820.35
//
Query:       EFC38344.1  [L=1089]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-06   26.9   0.1    1.7e-05   24.9   0.1    2.2  1  U-box     U-box domain
  ------ inclusion threshold ------
        2.7    8.3   4.4          8    6.8   0.3    3.3  3  CotJB     CotJB protein


Domain annotation for each model (and alignments):
>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.1   1.9e-09   1.7e-05       5      71 ..     885     951 ..     882     953 .. 0.86

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 1.9e-09
                 GB-TTT-SB-SSEEEETTTEEEEHHHHHHHHTT..SSB-TTT-SB--GGGSEE-HHHHHHHHHHHHHC CS
       U-box   5 fldpitlelmkdPvilpsgvvvdrstiekhlls.rdktdPftrepltqdqlipnlelKekIdefleek 71 
                   +pi++ l+ dPv++++ v+++++  +k+  + ++ ++P+t   +t  + + +  +++k++ +l+++
  EFC38344.1 885 ITCPISMCLFFDPVVAADNVTYEKEVYKKWCVKkNEVVSPVTGRRITT-KFTNDVVIRNKVQIYLQKH 951
                 57***************************987736778****666654.6899999********9998 PP

>> CotJB  CotJB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.3   0.00089         8      34      61 ..     309     336 ..     303     344 .. 0.89
   2 ?   -0.3   0.1      0.15   1.3e+03      14      36 ..     753     775 ..     747     800 .. 0.72
   3 ?    0.1   0.0      0.11   9.5e+02      20      34 ..     811     825 ..     804     828 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.00089
       CotJB  34 fnkyskkrkelkkeYeekygPLtldgvs 61 
                 + +++kk+++l+k Y++ ++ Lt+ +++
  EFC38344.1 309 YTEIKKKYEDLMKLYTKACKELTVAQAE 336
                 899********************98775 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.15
       CotJB  14 vvdlnLYLDthPddkealelfnk 36 
                 ++d++ +LD h d ++  + + k
  EFC38344.1 753 AKDIQEFLDRHSDLSTTKDGLTK 775
                 68999******986555444444 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.11
       CotJB  20 YLDthPddkealelf 34 
                 YLD hP+ k  +e+ 
  EFC38344.1 811 YLDKHPTIKSKYEQV 825
                 9*****988877765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1089 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1519  (0.0847231); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.07u 0.38s 00:00:01.45 Elapsed: 00:00:00.58
# Mc/sec: 5680.73
//
Query:       EFC38345.1  [L=1329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
         10    4.2   7.7         15    3.6   7.7    1.1  1  SSP160    Special lobe-specific silk protein SSP160


Domain annotation for each model (and alignments):
>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   7.7   0.00084        15     669     701 ..     611     643 ..     600     648 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.00084
      SSP160 669 dpgsvpdeattttssttttttttttaapttttt 701
                   g+ p++++t+t+ ttt+ tt t+aap     
  EFC38345.1 611 PQGTTPQQTSTSTTNTTTANTTNTSAAPKRIVK 643
                 46889***********************87665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1840  (0.102627); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.11u 0.36s 00:00:01.47 Elapsed: 00:00:00.56
# Mc/sec: 7113.62
//
Query:       EFC38346.1  [L=736]
Description: adenylate kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.9e-36  124.8   0.0    1.1e-35  123.0   0.0    1.9  2  ADK              Adenylate kinase
    3.6e-23   82.5   0.1    4.5e-22   78.9   0.0    2.6  2  AAA_17           AAA domain
    5.9e-05   23.6   1.9    0.00075   20.0   0.2    3.4  2  AAA_18           AAA domain
    0.00032   20.9   0.9     0.0089   16.2   0.9    2.6  1  AAA_33           AAA domain
    0.00052   20.3   0.1       0.33   11.2   0.0    2.4  2  Hydin_ADK        Hydin Adenylate kinase-like domain
  ------ inclusion threshold ------
       0.02   14.8   0.1      0.069   13.1   0.1    1.9  1  RRF              Ribosome recycling factor
      0.031   13.9   0.2        4.7    6.8   0.0    2.8  2  Thymidylate_kin  Thymidylate kinase
        0.1   13.0   0.5        0.6   10.5   0.1    2.5  2  AAA              ATPase family associated with various cellul
       0.14   12.4   0.1       0.35   11.1   0.1    1.6  1  AAA_28           AAA domain
       0.19   12.0   0.5         25    5.1   0.0    3.1  3  AAA_22           AAA domain


Domain annotation for each model (and alignments):
>> ADK  Adenylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.5   2.6e+03      80     123 ..      64     135 ..      47     176 .. 0.62
   2 !  123.0   0.0   5.9e-39   1.1e-35       1     148 [.     538     713 ..     538     716 .. 0.95

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.5
                 ESB-SSHHHHHHHHHHHHHHTS.EESEEEEEE--HHHHHHHHHT............................G CS
                 xxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxx............................x RF
         ADK  80 DGfPRtveqaealeelleeekv.kldlvleldvpeevlveRltg............................D 123
                 D f + +++  +le+ le  +  +  +v +l+ ++++lv+++ +                             
  EFC38346.1  64 DLFKKGTSERAKLEH-LELVESsTELTVWQLNKEKDALVKKVFKnvqygfidlsrkkpnllrktvfgwddvfV 135
                 456666667777777.444444044467889999999999888766666666666555555555555555550 PP

  == domain 2  score: 123.0 bits;  conditional E-value: 5.9e-39
                 EEESTTSSHHHHHHHHHHHHTSEEEEHHHHHHHHHHCT-HHHHHHHHHHHTTSS--HHHHHHHHHHHHHCHGTT.TEEEEESB-SSHHHHHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK   1 llGaPgaGKGtqaeklvkkyglahlstGdllRaevksgtelGkeakevmdkgelvpdevvvklvkeelekedkk.kgfllDGfPRtveqaealeellee 98 
                 ++G Pg+GKGtq++ +++kygl+h+stGdl+R+ ++++telGk+++++++ g l+pde+++ +  +++ ked+k kg++lDG+PRt+++ e + +    
  EFC38346.1 538 IMGLPGCGKGTQSKLIAEKYGLVHISTGDLVREVISKQTELGKKCEAIINTGGLLPDELINPIFLDRILKEDCKtKGWILDGYPRTTSNLEFVRA---- 632
                 79*****************************************************************9999665289**********99887777.... PP

                 HTSEESEEEEEE--HHHHHHHHHT...............................GSHHHHHHHHHHHHHHHHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxx...............................xxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK  99 ekvkldlvleldvpeevlveRltg...............................DneetvkkRletykkqtkplidyykk 148
                 +  +++ v+ l +++++ +eR  g                               Dnee+ k R+++y++++    d++ +
  EFC38346.1 633 NRLNVTGVIFLTLDDDTAIERQCGritdpltgaiyhskflppteeirerlvkratDNEEKAKIRVKVYHDEMDQAFDWFPE 713
                 999******************9999999*******************************************9999998865 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.9   0.0   2.5e-25   4.5e-22       1     122 [.     539     657 ..     539     662 .. 0.88
   2 ?   -0.2   0.1      0.68   1.2e+03     112     128 ..     675     691 ..     670     722 .. 0.60

  Alignments for each domain:
  == domain 1  score: 78.9 bits;  conditional E-value: 2.5e-25
                 EE-TTSSHHHHHHHHHHHHTEEEEEHHHHHHHHHHTT.TSHSSHHHHC.TSHHHHHHHHHHHHHHHHHHHH.HSSEEEEEE-SEEEETTEEEESSHHHH CS
      AAA_17   1 lGgPGsGKgtqceklvekygfthlsaGdllreeakrg.glakardemr.klpleekkelqkeaaekiaeea.kkkgvlvdghprikeqagfldglpkev 96 
                 +G+PG+GKgtq++ ++ekyg+ h+s+Gdl+re+++++ +l+k+ +++  ++ l +++ +  +  ++i +e+ k+kg+++dg+pr+  + +f        
  EFC38346.1 539 MGLPGCGKGTQSKLIAEKYGLVHISTGDLVREVISKQtELGKKCEAIInTGGLLPDELINPIFLDRILKEDcKTKGWILDGYPRTTSNLEF------VR 631
                 59********************************999678888887774789***************88865999*********9665554......33 PP

                 HHHH..SEEEEEE--HHHHHHHHHHH CS
      AAA_17  97 leelkpdaiilleadpeeilerrlkd 122
                  + l+++ +i+l  d+++ +er   +
  EFC38346.1 632 ANRLNVTGVIFLTLDDDTAIERQCGR 657
                 589*******************9876 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.68
                 HHHHHHHHHHHTTST-T CS
      AAA_17 112 peeilerrlkdrtrgrd 128
                  eei+er+ k+ t + +
  EFC38346.1 675 TEEIRERLVKRATDNEE 691
                 45666666665444333 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.2   4.2e-07   0.00075       1     110 [.     536     654 ..     536     661 .. 0.68
   2 ?   -0.2   0.1      0.76   1.4e+03     102     121 ..     674     693 ..     672     709 .. 0.77

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 4.2e-07
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf.gvnlrdvakenglllevdpe......aldeskrldedkldklldaleenssaleegknlvidghlaeleseaak 92 
                 I+++G pG+GK t +k ++++ g+ ++  +d+++e  +  ++  +       +   +  +  +   l ++l+e ++     k +++dg +      +++
  EFC38346.1 536 IIIMGLPGCGKGTQSKLIAEKYGLvHISTGDLVREVISKQTELGKkceaiiNTGGLLPDELINPIFLDRILKEDCK----TKGWILDGYPRTTSNLEFV 630
                 9********************8779555555555555555555553333442222222222233346677777664....7889999988777777777 PP

      AAA_18  93 dikk......vvLtaspeelleRl 110
                 ++++      ++Lt+++++ +eR 
  EFC38346.1 631 RANRlnvtgvIFLTLDDDTAIERQ 654
                 7777777999*********99995 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.76
      AAA_18 102 speelleRlekRgyeeakik 121
                 ++ee +eRl kR + + +++
  EFC38346.1 674 PTEEIRERLVKRATDNEEKA 693
                 46999*******97766553 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.9     5e-06    0.0089       2     131 ..     536     698 ..     536     709 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 5e-06
      AAA_33   2 vllvGlpGsGKstlaerllkklgavllssdt..................................lrrrlfgtdqqsktdytrvldrlyqilnelarka 66 
                 +++ GlpG+GK t ++ +++k g v++s+ +                                  +++r+ ++d ++k +  +  +r++  l e++r +
  EFC38346.1 536 IIIMGLPGCGKGTQSKLIAEKYGLVHISTGDlvreviskqtelgkkceaiintggllpdelinpiFLDRILKEDCKTKGWILDGYPRTTSNL-EFVRAN 633
                 6889***************************5555555555555555555555555555555555555555555555557777778888777.888877 PP

      AAA_33  67 lsagrnvil....datnlsrrerarflklarrlgvpvrivvvetdeetlkeRlakRaangddrsevpee 131
                 +    +vi+    d t ++r +  r+   +   g ++    + ++ e+++eRl kRa +++++++   +
  EFC38346.1 634 RLNVTGVIFltldDDTAIER-QCGRITDPLT--G-AIYHSKFLPPTEEIRERLVKRATDNEEKAKIRVK 698
                 77777788888866665554.4444555554..4.5666678899999999999999988766655554 PP

>> Hydin_ADK  Hydin Adenylate kinase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.0   0.00019      0.33       2      42 ..     536     576 ..     535     586 .. 0.94
   2 !    6.9   0.0    0.0037       6.7     170     197 ..     591     619 ..     581     620 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00019
   Hydin_ADK   2 iivhGaPlsGKtatavtLakkYeaAlltiDsvvleAisdgn 42 
                 ii+ G P  GK + +  +a kY+   ++  ++v e is+++
  EFC38346.1 536 IIIMGLPGCGKGTQSKLIAEKYGLVHISTGDLVREVISKQT 576
                 9*************************************875 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0037
   Hydin_ADK 170 vLPedllveIlsERlqlndCy.rGvvfDg 197
                 +LP++l+  I  +R+  +dC  +G ++Dg
  EFC38346.1 591 LLPDELINPIFLDRILKEDCKtKGWILDG 619
                 7*******************548999998 PP

>> RRF  Ribosome recycling factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   3.9e-05     0.069      85     120 ..     673     708 ..     666     734 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.9e-05
                 SSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         RRF  85 plTeErrkelvkeakkaaekakvairniRrdankkl 120
                 p+TeE r+ lvk+a +  ekak++++    ++ +++
  EFC38346.1 673 PPTEEIRERLVKRATDNEEKAKIRVKVYHDEMDQAF 708
                 78***********************98888877766 PP

>> Thymidylate_kin  Thymidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0    0.0026       4.7       3      53 ..     540     592 ..     538     610 .. 0.76
   2 ?    4.0   0.1      0.02        36     129     185 .]     676     732 ..     671     732 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0026
                      ESTTSSHHHHHHHHHHHHHHTTE..EEEESS..STTSHHHHHHHHHHHTCS--- CS
  Thymidylate_kin   3 GlDGaGKttqaellkerlkeegik.vvltre..pggteiGekirelllkeeele 53 
                      Gl G GK tq++l++e++   +i+   l re  +++te+G+k  ++++ +  l 
       EFC38346.1 540 GLPGCGKGTQSKLIAEKYGLVHIStGDLVREviSKQTELGKKCEAIIN-TGGLL 592
                      899***************999999855555533688999999999988.55444 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.02
                      HHHHTSCCTTSSTTTSHHHHHHHHHHHHHHHHHHHH.TTSTE.EEEETTS-HHHHHHHH CS
  Thymidylate_kin 129 evalkRlakrdeldeeeeeqldflrkvrerylelak.ederi.liidasksieevheeI 185
                      e+  +Rl kr++  ++ee+ +   + ++  ++++++ ++e+i + ida+ s eev e+I
       EFC38346.1 676 EEIRERLVKRAT--DNEEKAKIRVKVYHDEMDQAFDwFPEEIsHKIDATPSPEEVFEAI 732
                      555689999999..4444444446777788888888888777478**********9987 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.4   2.5e+03      49      69 ..     452     472 ..     435     475 .. 0.83
   2 ?   10.5   0.1   0.00033       0.6       1      41 [.     536     574 ..     536     597 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.4
                 HHHHHHHTSTSEEEEEETGGG CS
         AAA  49 lfkeakekakpsilfiDEida 69 
                 ++k +kekak++ + iDEi++
  EFC38346.1 452 ILKFIKEKAKTKTMTIDEIEN 472
                 67778888867999****986 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00033
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTH CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsellskyvge 41 
                 ++++G pG+GK +  k +a++ g  ++ is  +l+ +++++
  EFC38346.1 536 IIIMGLPGCGKGTQSKLIAEKYG--LVHISTGDLVREVISK 574
                 5789*****************65..5888888888665544 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   0.00019      0.35       1      44 [.     535     581 ..     535     592 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00019
      AAA_28   1 kivitGgestGKTtlleaLaar.gypvv..pEaareileeklakged 44 
                 +i+i+G +++GK t ++ +a++ g +++   + +re+++++++ g++
  EFC38346.1 535 RIIIMGLPGCGKGTQSKLIAEKyGLVHIstGDLVREVISKQTELGKK 581
                 79******************98899988899*******999987664 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         6   1.1e+04      92     112 ..      55      79 ..      45      88 .. 0.64
   2 ?    5.1   0.0     0.014        25      39     103 ..     409     473 ..     385     492 .. 0.83
   3 ?    3.3   0.1      0.05        90       8      29 ..     536     557 ..     534     581 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 6
      AAA_22  92 ielliiDEaqhlr...s.eealeeL 112
                   ++i D ++ +    s  + le+L
  EFC38346.1  55 AICFICDQMDLFKkgtSeRAKLEHL 79 
                 3689999999996654254444444 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.014
      AAA_22  39 rpevvfvtlpsstsskdllrellralglelkaerlsseellealeqalraravielliiDEaqhl 103
                 ++++++v + +  +  ++ r ++ +l      e+ +s+ +++ + + ++++a+++ + iDE+++ 
  EFC38346.1 409 EKDTIEVLPEERRNFNTFVRYMCGQLAIFSAFETPESSIYRDGILKFIKEKAKTKTMTIDEIENA 473
                 56778888888889999999999999987777999999999**********************97 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.05
      AAA_22   8 lvvtGesGtGKTtllrrlleql 29 
                 ++++G +G+GK t  + ++e++
  EFC38346.1 536 IIIMGLPGCGKGTQSKLIAEKY 557
                 79*********99999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (736 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       817  (0.0455686); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.83u 0.33s 00:00:01.15 Elapsed: 00:00:00.54
# Mc/sec: 4082.65
//
Query:       EFC38347.1  [L=524]
Description: [Fe] hydrogenase maturation protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      7e-17   62.3   0.0    1.1e-16   61.7   0.0    1.3  1  Radical_SAM  Radical SAM superfamily
     0.0051   16.9   0.0      0.011   15.8   0.0    1.6  1  BATS         Biotin and Thiamin Synthesis associated domain


Domain annotation for each model (and alignments):
>> Radical_SAM  Radical SAM superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.7   0.0   1.2e-20   1.1e-16       1     164 [.     194     365 ..     194     368 .. 0.91

  Alignments for each domain:
  == domain 1  score: 61.7 bits;  conditional E-value: 1.2e-20
                  EEEESEESS--TTTSCCTTHHHHHHHHHHHHHHHHHHHHHHHHHTTSEEEEEESSTGGGSTTHHHHHHHHHHTC...........CCTEEEEEEECSS CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........xxxxxxxxxxxxx RF
  Radical_SAM   1 vvvtrgCnlrCsfCarpetvrregrgrslsveeileevkelkaekgvkevilgggepllypdfvellerlakla...........vpgiritvetngt 87 
                  +++++ C  +C++C ++++  + ++ +++++eei+e++ ++++++  + ++l +ge +   ++ +l++ +++++           ++g+ i++ + ++
   EFC38347.1 194 IEFSNVCQKDCNYCGIRKH--MQVPRYTMPKEEIIEQAIWAYENH-FGSIMLQSGELNTEGRISMLVDVIREIKkrtggggpgewNKGLGIALGVGEL 288
                  6899**************8..********************7666.***************************9999****99999999999999999 PP

                  CHGHHHHHHHHHTT-SEEEEEEBSSSHH..HHHHHHT..CTSHHHHHHHHHHHHHHTTSETEEEEEEEBTTTSHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Radical_SAM  88 lpdeeklerllelgvdrvslgleaadde..kvlklmn..rghtfeevlealeklreagikrvvdrivglpGendeeleell 164
                     +e  +rl ++g  r+ l +e+ ++e     kl+    +h +ee++++le+l + g    + +++++p+++ ++l + l
   EFC38347.1 289 S--RESYQRLYDAGAHRYLLRIETSNPElyS--KLHPndENHVWEERKKCLETLMDIGYQTGTGVMIMIPNQTVQDLADDL 365
                  9..9************************553..3332448999*********************************98866 PP

>> BATS  Biotin and Thiamin Synthesis associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   1.3e-06     0.011      13      76 ..     389     481 ..     352     489 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.3e-06
                 C...........................HHHHHHHHHHSTTSECCCTCHH-HHHHHH..HHHCCT--EEE-C---TTTGGGSESSTT-TCCCC CS
        BATS  13 l...........................lkiiaalRlllPkagillsgResaefrdq..lllklGansisagsktevggyaflttdgrsleed 76 
                 +                           lk+ a++R+l+P+a+i++++  +a +     ++l  Gan ++   +++ ++ ++++++g+   +d
  EFC38347.1 389 IgkiwmeqyghmneaekkeynrvlfrlaLKMTALARILIPEANISATTALQAINPAGreIALSSGANMVMPIITPTKYRVNYQLYQGKPCIDD 481
                 45555555555555555555666677789**************9999987765543334888*********9987777777999998875444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (524 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.37s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 2934.63
//
Query:       EFC38348.1  [L=2538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.4e-46  158.2   0.2    6.4e-46  156.9   0.2    1.8  1  Pkinase      Protein kinase domain
    2.7e-28   99.1   0.3    2.7e-28   99.1   0.3    2.6  2  DOCK-C2      C2 domain in Dock180 and Zizimin proteins
    3.5e-27   95.3   3.6    1.5e-25   90.0   0.1    2.9  3  Pkinase_Tyr  Protein tyrosine kinase
  ------ inclusion threshold ------
      0.012   15.0   0.0      0.072   12.4   0.0    2.3  1  Kinase-like  Kinase-like
      0.016   15.3   0.5      0.097   12.8   0.5    2.4  1  V-set_2      ICOS V-set domain
       0.06   13.3   0.0        7.8    6.3   0.0    2.5  2  APH          Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  156.9   0.2   2.1e-49   6.4e-46       1     258 [.     592     863 ..     592     868 .. 0.87

  Alignments for each domain:
  == domain 1  score: 156.9 bits;  conditional E-value: 2.1e-49
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE....SSEEEEEEE--TTEBHHHHHH..... CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee....kdelylvleyveggeladlle..... 90 
                 y++l+ lG+G+ ++V++++ek+tg+ vA+K+i+   ++     ++++E +il+ lkh+ i+ +++ +e+    ++ +++ + +  +g+++ +++     
  EFC38348.1 592 YTELKSLGTGGQATVFSGLEKTTGERVALKVINAGGNSA----QLWNEFNILRVLKHSSIIPVWKLYETknifNSMIMITMPVYIHGDMTAFITkfapk 686
                 78999****************************998876....578***********************888777778899999999999999989998 PP

                 .HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEET.....TTE........EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBS CS
     Pkinase  91 .rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLide.....kge........lKitDFGlakelessskltsfvgtseYlAPEvlkeneys 175
                  +   ++++ + +++ qi  +++y HskgiiHrDlKp+Ni+i++     k +        + ++DFGl+k++++s  + s+vgt  +++P  l + ++s
  EFC38348.1 687 yDTNPFTPHCIIDMVLQITDAIQYTHSKGIIHRDLKPDNIFISSleldkK-NrklitsckVTLGDFGLSKNIQQSM-AVSVVGTLGWMSPDHL-NGNFS 782
                 76677**************************************7667651.1556667679*************98.9***************.6679* PP

                 HHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHH CS
     Pkinase 176 kkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeel 258
                  k+D+WslG+i+y l++    + ++++  + ++ +++ +k+++ +  +k+++  +s++ e +  +++kll+k+p++Rl+ +e 
  EFC38348.1 783 LKTDMWSLGCIIYYLISLDAALLNTNDMINENHAAHK-VKMRENM-YKKMNSTLPSKFVELIDIVVTKLLEKNPEERLSSHEF 863
                 *******************999988888777777777.3333333.457778888888888888899************9875 PP

>> DOCK-C2  C2 domain in Dock180 and Zizimin proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   1.2       2.7     8e+03     144     151 ..     343     350 ..     253     382 .. 0.52
   2 !   99.1   0.3   8.9e-32   2.7e-28       5     193 ..    1512    1677 ..    1510    1679 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.7
     DOCK-C2 144 elppsgYl 151
                 + ++ gY 
  EFC38348.1 343 QNHHRGYS 350
                 22334555 PP

  == domain 2  score: 99.1 bits;  conditional E-value: 8.9e-32
     DOCK-C2    5 rNdlYvtlksgefsskgskssakniqvtvevrdsdger...lekaiylgsgeelvsefrsvvlyhnkqptfneeiKialpieltekhHLlFtfrhvs 98  
                   N+lY+++ s  f +++   ++ n+ + v+++++d ++    e++++ +++++  +e +s+v+y++++p+fn+e+K++lp +l ++ HLlFtf +v+
  EFC38348.1 1512 SNNLYIYPLSTAF-KRRLFLKDMNVGIIVKFKRNDRDIsdeGEQVFI-KKNNKTFKEGFSSVSYQSTSPQFNDELKLQLPEQLGSGDHLLFTFVNVD 1606
                  59***********.5677899*************77777788999*9.88899999***************************************** PP

     DOCK-C2   99 ceekkkekdkeeeekpfgyaflpLlkedgraflkdgehelpvykkelppsgYlslpssrtssseeqkgpsekwldnskdtfkvrtklcSTiltqd 193 
                  c        +e++ +++g ++  Ll + +  + + g+  lp+yk  l+p++Yl+++            +++k    +   fkv+++ +ST++t+d
  EFC38348.1 1607 CAG------DEKNVQVVGHSYYMLLGK-HGLLATHGNLILPIYK-RLTPKSYLQAN------------EDTK----KNGEFKVEFQPISTLYTTD 1677
                  *42......335579**********96.6677799********9.68899***532............2344....7899*************99 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.0   0.1   4.9e-29   1.5e-25       4     250 ..     595     858 ..     592     864 .. 0.81
   2 !    5.0   0.0    0.0042        13      51     121 ..     907     983 ..     896     988 .. 0.83
   3 ?   -1.8   0.3       0.5   1.5e+03      33     103 ..    1690    1770 ..    1684    1779 .. 0.63

  Alignments for each domain:
  == domain 1  score: 90.0 bits;  conditional E-value: 4.9e-29
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSS....EEEEEE--TTEBHHHHHHHT.. CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeep....llivteyvkgGdLlkfLrkk.. 95 
                   k+lG G  ++V++g  k    ++ ++Va+K+++++ ++    +l +e +i++ lkh  i+ +  ++  ++     ++i +    +Gd+  f++k   
   EFC38348.1 595 LKSLGTGGQATVFSGLEK----TTGERVALKVINAGGNSA---QLWNEFNILRVLKHSSIIPVWKLYETKNIfnsmIMITMPVYIHGDMTAFITKFap 685
                  589************999....8999*******8777666...9*****************999998843333444899999999********99888 PP

                  ..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE............TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHH CS
  Pkinase_Tyr  96 ..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse............nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslke 179
                    +++++t + +++++lq+ ++++y +sk ++Hrdl   N+++s+            + +v ++DfGL+++i    +++++ +    + Wm+p  l+ 
   EFC38348.1 686 kyDTNPFTPHCIIDMVLQITDAIQYTHSKGIIHRDLKPDNIFISSleldkknrklitSCKVTLGDFGLSKNI----QQSMAVSVVGTLGWMSPDHLN- 778
                  88999***************************************99******99998889999*********....556677788899******996. PP

                  SEEEHHHHHHHHHHHHHHHHTTSSGT..TTTS.HHHHHHHHHHTTEES-B......BTTSBHHHHHHHHHHT-SSGGGS- CS
  Pkinase_Tyr 180 kkftsksDvWsfGvllwEiftlgesp..ypgl.kneevleklkegkrlek......pekcpeelyelmkkcweedpeeRp 250
                  ++f+ k+D+Ws G +++ +++l +     +++ +++++++k+k ++++ k      p+k  e +  +++k +e++peeR 
   EFC38348.1 779 GNFSLKTDMWSLGCIIYYLISLDAALlnTNDMiNENHAAHKVKMRENMYKkmnstlPSKFVELIDIVVTKLLEKNPEERL 858
                  67******************987653225666455555666655555544110000344444444456777777777776 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0042
                  HHHHHHTS.-BTTB--EEEEEE.....SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr  51 eakimkkl.khpnivkllgvct.....keepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLes 121
                  + k++ +l + + i k+lg  t      +++ + ++   +g +L+ +L  ++ + ++l+d+l++ l++A ++e +++
   EFC38348.1 907 QFKTLIQLrDIQYITKVLGYFTtydelTDQEEIYILHKPQGTNLKAYLVPSNPRYVSLHDKLEILLKIATAIEEINR 983
                  567888888889999999999977766444466677778999*********9*******************998876 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.5
                   EEEEST...TSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEESSSSEEEEEE--TT......EBHHHHHHHTCTTTSBHH CS
  Pkinase_Tyr   33 vKtlke...eateeekeelleeakimkkl.khpnivkllgvctkeepllivteyvkg......GdLlkfLrkkekekltlk 103 
                   vK++k+   e+ +e ++++ + +k ++k+ + +n+++++  +++e  l+i ++  ++      G L+++L k +k++ ++k
   EFC38348.1 1690 VKVMKSiygENLAEIQNNISKKLKNLEKVvDFRNLIQYMPQIVDELLLMITLKQFPNvqsgafGLLNSYLDKLKKTERNTK 1770
                   555554111344444888999999999999999999999999976666665544322111111467777776655555555 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   2.4e-05     0.072     149     262 ..     700     826 ..     675     857 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.4e-05
  Kinase-like 149 lTlqlirlaanLqakglvhgkftvdnll.....ldekgglmlggftaLvragtkvvlsevekgfaPpEllgsrggyt.rknktkmthkldaWqlGlvi 240
                  + lq+   +++ ++kg++h ++++dn++     ld+k +  ++  +  v+ g+ +  s++ +      ++g  g     + + +++ k+d W lG  i
   EFC38348.1 700 MVLQITDAIQYTHSKGIIHRDLKPDNIFissleLDKKNRKLITSCK--VTLGDFGL-SKNIQQSMAVSVVGTLGWMSpDHLNGNFSLKTDMWSLGCII 794
                  5577777888888999999999999887444445666655555443..56666666.444444444455555555330345789************** PP

  Kinase-like 241 yriwclklPltlateeakeew..........k 262
                  y++ +l++ l +  + ++e++           
   EFC38348.1 795 YYLISLDAALLNTNDMINENHaahkvkmrenM 826
                  *******9998888888888755555555552 PP

>> V-set_2  ICOS V-set domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.5   3.3e-05     0.097      41     110 ..    1445    1518 ..    1432    1520 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.3e-05
     V-set_2   41 CdLtk.....tkesgnavsiknvklCqaqlsnnsvsffLenldsshasyytCelsifdPPPfikkilseeyLyiy 110 
                  C+Lt+     t  s+ a+s ++++   a l  +s+sf+L+  + ++   y+C++  f P  f  +   ++ Lyiy
  EFC38348.1 1445 CELTRayeatTVSSKAAESLTDLNDQFATLDLKSTSFYLKQTNGNNNGSYMCKMFTFAP-NFRSSLTDSNNLYIY 1518
                  666662222144577778888888888889999***********************986.686666677889998 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.013        39      18      59 ..     613     655 ..     597     669 .. 0.86
   2 ?    6.3   0.0    0.0026       7.8     164     181 ..     712     729 ..     693     741 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.013
                 ETT--EEEEEE-TTS-HHHHHHHHHHHHHHHHTT-.B--B-CT CS
         APH  18 tpagryvlrrnpparaaeeirrevallrlLakagv.pvPevla 59 
                 t++ r++l++++++ + +++ +e+ +lr+L  + + pv++++ 
  EFC38348.1 613 TTGERVALKVINAGGNSAQLWNEFNILRVLKHSSIiPVWKLYE 655
                 23359****************************9*9***9997 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0026
                 S-EEEE-SS-SGGGEEEC CS
         APH 164 lptvllHgDlhpgNllvd 181
                  +++++H+Dl+p+N+ + 
  EFC38348.1 712 HSKGIIHRDLKPDNIFIS 729
                 5789***********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1728  (0.0963802); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.46u 0.34s 00:00:01.80 Elapsed: 00:00:00.56
# Mc/sec: 13557.17
//
Query:       EFC38349.1  [L=158]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      3e-23   81.9   0.8    3.5e-23   81.7   0.8    1.1  1  HSP20       Hsp20/alpha crystallin family
    1.4e-05   24.6   0.0    2.1e-05   24.0   0.0    1.3  1  ArsA_HSP20  HSP20-like domain found in ArsA
     0.0066   15.5   0.5      0.008   15.2   0.5    1.1  1  Vps26       Vacuolar protein sorting-associated protein 26


Domain annotation for each model (and alignments):
>> HSP20  Hsp20/alpha crystallin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.7   0.8   5.9e-27   3.5e-23       2     101 ..      53     157 ..      52     158 .] 0.89

  Alignments for each domain:
  == domain 1  score: 81.7 bits;  conditional E-value: 5.9e-27
                 --SSEEEEEEEEE-TT--CCCEEEEEETTE..EEEEEE--....---TT----SS---EEEEEE--STTB-TTT-EEEEETTEEEEEEEBSS--...-- CS
       HSP20   2 ikeeeeefevkldvpglkkeelkvkvednr..vlvkgehe..eeeedekglikerssrkFsrkftLPenvdadkvkaslkdGvLtvtvpkkepekk.kk 95 
                 + e+++ + vk ++pglkke+++++v+d++  ++ +ge +  + +e+e ++++er ++kFsr+++LP+nvd + +ka++++GvL +++pk e+++k  k
  EFC38349.1  53 VSETDKCICVKSNLPGLKKEDVRIDVDDEKrlLTFSGETKseKTDENEIYHRSERYYGKFSRSMRLPQNVDLNGIKANMNEGVLNISIPKVEQKEKqVK 151
                 6678888999*****************998889999999976667778899****************************************99988567 PP

                 ------ CS
       HSP20  96 erkiqi 101
                  r+i +
  EFC38349.1 152 TRSIGV 157
                 777765 PP

>> ArsA_HSP20  HSP20-like domain found in ArsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   3.6e-09   2.1e-05       3      62 ..      59     139 ..      57     140 .. 0.92

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 3.6e-09
  ArsA_HSP20   3 eyvlkldLPfvdkee..idlsrsgdeLtIkig....................nfrRqitLPsvlarkevtsAkfedgvLeIr 62 
                  + +k +LP+++ke+  id+  +   Lt + +                    +f+R++ LP+ ++   + +A +++gvL+I+
  EFC38349.1  59 CICVKSNLPGLKKEDvrIDVDDEKRLLTFSGEtksektdeneiyhrseryygKFSRSMRLPQNVDLNGI-KANMNEGVLNIS 139
                 5678899******975588888899******************************************99.**********97 PP

>> Vps26  Vacuolar protein sorting-associated protein 26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.5   1.3e-06     0.008       6      79 ..      73     147 ..      69     157 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.3e-06
                 EEEEEETTTTTS-EEEEE-GGG-EEEEEEE-TT--EEEEEEEEESST--EEESEEEEEE.EEEEEETTTGGGEEE CS
       Vps26   6 dieikldneeerktvdvktekgkkeklkvyedgeslsGvvtirlkdskkvehqGikvel.iGqiellydkgnsvd 79 
                 d+ i +d+e+   t   +t+  k++++++y+  e   G+ + +++  ++v+ +Gik ++  G++++   k+++ +
  EFC38349.1  73 DVRIDVDDEKRLLTFSGETKSEKTDENEIYHRSERYYGKFSRSMRLPQNVDLNGIKANMnEGVLNISIPKVEQKE 147
                 89999999999999999999*************************************997355555544444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (158 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       514  (0.0286686); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.35s 00:00:00.91 Elapsed: 00:00:00.54
# Mc/sec: 880.96
//
Query:       EFC38350.1  [L=826]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-08   34.9   0.1      3e-08   33.4   0.1    1.8  1  F-box-like  F-box-like
     0.0031   17.4   0.2       0.01   15.7   0.2    1.9  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.4   0.1   3.3e-12     3e-08       4      36 ..      28      60 ..      26      64 .. 0.94

  Alignments for each domain:
  == domain 1  score: 33.4 bits;  conditional E-value: 3.3e-12
  F-box-like  4 LPdEiLlqIFsyLppsdLlrlalVCrrWrrval 36
                LPd iL+qIFsyL++ d   ++++C  Wrr+++
  EFC38350.1 28 LPDHILSQIFSYLSFHDFREVTRTCMMWRRICF 60
                9******************************96 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.2   1.1e-06      0.01       6      37 ..      28      59 ..      26      64 .. 0.94

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.1e-06
                S-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHH CS
       F-box  6 LPsevlrhILerLplsdllalrrVSkgwrili 37
                LP+++l +I+++L++ d     r++  wr+++
  EFC38350.1 28 LPDHILSQIFSYLSFHDFREVTRTCMMWRRIC 59
                9*****************************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (826 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       567  (0.0316247); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.50
# Mc/sec: 4938.59
//
Query:       EFC38351.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       674  (0.0375927); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 1533.10
//
Query:       EFC38352.1  [L=470]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-45  152.5  16.9    4.6e-15   55.1   0.0    7.2  8  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.041   13.1   1.8         23    4.3   0.0    3.9  4  DUF3666   Ribose-5-phosphate isomerase


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.4   2.1e-07    0.0019       6      46 ..     161     226 ..     158     227 .. 0.90
   2 !   26.4   0.3   4.5e-10   4.1e-06       1      44 [.     233     277 ..     233     281 .. 0.91
   3 !   14.3   1.3   2.8e-06     0.025       1      47 [.     258     305 ..     258     308 .. 0.91
   4 !   31.6   1.0   1.1e-11     1e-07       1      49 []     283     333 ..     283     333 .. 0.91
   5 !   22.5   0.1   7.4e-09   6.6e-05       1      28 [.     310     337 ..     310     351 .. 0.92
   6 ?   -1.3   0.0       0.2   1.8e+03      19      41 ..     355     377 ..     335     384 .. 0.72
   7 !   55.1   0.0   5.2e-19   4.6e-15       1      49 []     385     433 ..     385     433 .. 0.99
   8 !   21.2   0.0   1.9e-08   0.00017       2      31 ..     436     465 ..     435     466 .. 0.94

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.1e-07
     DUF4116   6 leavkkngsalkylseeLkn.........................DkeivlkAvkqngtalsyase 46 
                 ++a++ ++++++y+++ +k+                         D ++v+ + k++ ++l yas+
  EFC38352.1 161 MHAIELDPKCYTYVPDYIKRmkhiakkvfirnpslgrlipkeileDTDFVMDIYKSSQSILFYASP 226
                 899999999999999999998889999999999999999999999999999999999999999997 PP

  == domain 2  score: 26.4 bits;  conditional E-value: 4.5e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsya 44 
                 Dr ++ ea+k++ + ++++see++ D+ei+  ++ ++  +++ y+
  EFC38352.1 233 DRGFMIEALKRDVCLIRNCSEEIRTDREIIDMIIDIDAaSSFQYI 277
                 899***************************999988877777776 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 2.8e-06
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkA.vkqngtalsyasee 47 
                 DrEi+  +++++  s+++y+  ++k D +iv+ A  k+n ++l y+  +
  EFC38352.1 258 DREIIDMIIDIDaASSFQYIG-KFKEDEDIVKTAlFKSNFKILHYINSD 305
                 9***********669******.***********9889999999999766 PP

  == domain 4  score: 31.6 bits;  conditional E-value: 1.1e-11
     DUF4116   1 DrEivlea.vkkngsalkyl.seeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D++iv+ a +k+n ++l+y+ s+ L n++e+vl ++k+ng+ ++ ++e+++
  EFC38352.1 283 DEDIVKTAlFKSNFKILHYInSDFLLNNRELVLTILKSNGKYINEMPESIK 333
                 99******7777778*****66779**********************9986 PP

  == domain 5  score: 22.5 bits;  conditional E-value: 7.4e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDke 28 
                 +rE+vl ++k+ng++++  +e++k+D+e
  EFC38352.1 310 NRELVLTILKSNGKYINEMPESIKKDRE 337
                 8**************************9 PP

  == domain 6  score: -1.3 bits;  conditional E-value: 0.2
     DUF4116  19 lseeLknDkeivlkAvkqngtal 41 
                 l + + +D+e  + +++ n++ l
  EFC38352.1 355 LYKIIESDREDFKSILQFNPDLL 377
                 56667788888888888777766 PP

  == domain 7  score: 55.1 bits;  conditional E-value: 5.2e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+ +ea+++ g++l+++see+k Dke+vl Av +ng+al yas++L+
  EFC38352.1 385 DRELLKEALSHSGYCLRFASEEFKADKELVLTAVTNNGSALMYASPKLK 433
                 9*********************************************997 PP

  == domain 8  score: 21.2 bits;  conditional E-value: 1.9e-08
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivl 31 
                 +E+vl av +ng+a++++s++L+++  i++
  EFC38352.1 436 EEVVLAAVMNNGKAIRFASKRLSSNQKIIK 465
                 7************************99986 PP

>> DUF3666  Ribose-5-phosphate isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0    0.0026        23      14      34 ..     283     303 ..     281     305 .. 0.89
   2 ?   -3.4   0.1      0.65   5.9e+03      29      35 ..     337     343 ..     336     345 .. 0.76
   3 ?    3.6   0.0    0.0041        37      14      23 ..     385     394 ..     375     398 .. 0.88
   4 ?    1.5   0.0     0.019   1.7e+02      14      23 ..     410     419 ..     408     421 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0026
                 -HHHHHHHT-STTHHHHHTTT CS
     DUF3666  14 DqdLvkgAisGerFqeyFFan 34 
                 D+d+vk+A+    F+ + + n
  EFC38352.1 283 DEDIVKTALFKSNFKILHYIN 303
                 99************9988766 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.65
                 HHHTTT- CS
     DUF3666  29 eyFFanc 35 
                 e+FF  +
  EFC38352.1 337 ECFFLAA 343
                 9***665 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.0041
                 -HHHHHHHT- CS
     DUF3666  14 DqdLvkgAis 23 
                 D++L+k+A+s
  EFC38352.1 385 DRELLKEALS 394
                 9*******98 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.019
                 -HHHHHHHT- CS
     DUF3666  14 DqdLvkgAis 23 
                 D++Lv +A++
  EFC38352.1 410 DKELVLTAVT 419
                 9*******97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (470 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       575  (0.0320709); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 3050.49
//
Query:       EFC38353.1  [L=3072]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      1e-40  139.2 155.5    1.5e-21   76.9   8.2   10.7 10  Beta_helix   Right handed beta helix region
    7.7e-20   71.3   0.0    1.6e-19   70.2   0.0    1.5  1  Pkinase_Tyr  Protein tyrosine kinase
    9.4e-17   61.2   0.0    1.9e-16   60.3   0.0    1.5  1  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
      0.096   13.4   0.8        3.9    8.2   0.0    3.0  3  HOCHOB       Homeobox-cysteine loop-homeobox


Domain annotation for each model (and alignments):
>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.5     0.053   2.4e+02      39     127 ..     243     329 ..     229     340 .. 0.64
   2 ?    3.7  10.8     0.011        50      30     138 ..     372     500 ..     342     510 .. 0.57
   3 !   17.8   8.6   5.3e-07    0.0024      39     156 ..     499     635 ..     475     637 .. 0.72
   4 ?  -10.0  13.0         4   1.8e+04      74     133 ..    1053    1121 ..    1032    1145 .. 0.47
   5 !   28.1  12.8   3.4e-10   1.5e-06       9     144 ..    1416    1548 ..    1367    1558 .. 0.55
   6 !   28.6  18.5   2.4e-10   1.1e-06       2     136 ..    1498    1680 ..    1497    1698 .. 0.80
   7 !   76.9   8.2   3.3e-25   1.5e-21       2     158 .]    1915    2119 ..    1914    2120 .. 0.91
   8 ?    0.3   4.7      0.12   5.4e+02      69     136 ..    2102    2168 ..    2095    2172 .. 0.74
   9 !   52.0  15.8   1.5e-17   6.9e-14       9     153 ..    2399    2570 ..    2394    2573 .. 0.93
  10 !   18.5  18.5     3e-07    0.0014      50     156 ..    2509    2640 ..    2504    2660 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.053
                 -EEES.-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT--- CS
  Beta_helix  39 neian.nsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdnggsGiyln.yssnntienNiidnnagsGividdsssnv 127
                 + i++  +g+  +++ ++n+ ++  +i d++   ia+  +  +l+++++++ n++ G +l    sn  + +Ni+ +na   i+id+++  v
  EFC38353.1 243 CQIQHiFQGDYQEMSTTTNFLVESTEIFDSY---IAVASSFLTLFKDCKFIGNDNLGTNLLlKLSNQLVFDNIVMSNAYLLISIDETN-IV 329
                 4445532222223333377777777777777...777778888888888888888887777557777777777777776666666666.33 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.011
                 SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---.........SEEE-TT--S--EEES-EEES-SS-......SEE-TT-S--EEES-EEEST CS
  Beta_helix  30 gssnvvienneiannsgsGiyilgssnntisnntisdnn.........gggialfgasnnlienneitdnggs......GiylnyssnntienNiidnn 113
                  s++++i n+ ++  sgs + i+g++n +i n ++ +n           + i l+  +n l+ n ++++  ++       +y+++  +++i ++++ nn
  EFC38353.1 372 FSDSCTIVNSFFQR-SGSILNIRGVKNLNIANVEFDENVqteavsnaqTSPIELKIIDNLLMINVTVRNQYSNylntayALYIQDVIRLKIDDCYFVNN 469
                 33335566444444.777777777777777777776666666666666777777777777777777777733333333466777777777777777777 PP

                 T......--SEE---TT---EEES-EEES-S CS
  Beta_helix 114 a......gsGividdsssnvtvtnNtitnnk 138
                 +      ++ i+ ++ +++  +t+ +++ nk
  EFC38353.1 470 RigalriHNPIFSESYKYSASITKTRFVANK 500
                 7555555444444444444444555555444 PP

  == domain 3  score: 17.8 bits;  conditional E-value: 5.3e-07
                 -EEES-SS-SEEE-TT-S-EEES-EEE---....SEEE-TT--S--EEES-EEES-.....SS-SEE-TT..-S--EEES-EEESTT...--SEE---T CS
  Beta_helix  39 neiannsgsGiyilgssnntisnntisdnn....gggialfgasnnlienneitdn.....ggsGiylny..ssnntienNiidnna...gsGividds 123
                 n+++   g  ++++   + +is+++++dn     gg+i +++ +++li+++++ +n     gg  i + +   + n ++++++  n+   + Gi+++ +
  EFC38353.1 499 NKCST-AGCAMSLEMIFYLNISECQFNDNDspsdGGAIVATALQRSLISDCTFQNNiaqgnGG-AIAFGGiiVYPNEVSGCVFIRNKakkAGGIYFEKN 595
                 44444.44445555557899*************999********************8886422.4544445566799999999999999999******* PP

                 T.---EEES-EEES-S.SEEEE-TT-SS.......--EEES- CS
  Beta_helix 124 s.snvtvtnNtitnnk.gaGiavvgsss.......nvtvrnN 156
                 + +++  +n++++ n+ +++ a+++ +s       ++ ++nN
  EFC38353.1 596 NlKSI--KNSKFFENSaDYAGAIYSLGSlpqsfvnSCSFSNN 635
                 *7666..99999999984444466655545555555555555 PP

  == domain 4  score: -10.0 bits;  conditional E-value: 4
                  TT--S--EEES-EEES-.....SS-SEE-TT........-S--EEES-EEESTT--SEE---TT.---EEES-E CS
  Beta_helix   74 lfgasnnlienneitdn.....ggsGiylny........ssnntienNiidnnagsGividdss.snvtvtnNt 133 
                  l  ++n+l+e    +d      g++G+++n+              + N+ dn +++    d s+ +n t++n+t
  EFC38353.1 1053 LLSSDNTLVELKIAYDAglsgvGSVGYSFNDtlgsivleI-----KSNTNDNSNNNNNNTDISNpNNSTIFNST 1121
                  4555566666666666633333333555554444333331.....22222222211111222221122333322 PP

  == domain 5  score: 28.1 bits;  conditional E-value: 3.4e-10
                  -E..EEESEEEES-SS-SEEE-SSS-.............EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---......SEEE-TT--S--EEES- CS
  Beta_helix    9 sn.vtiknntisnsggyGiylrgssn............vvienneiannsgsGiyilgs.snntisnntisdnn......gggialfgasnnlienn 85  
                  s+  t++n+++ +  +y+i l++s +            +vien++i++++++ i i +  +n++i+nn+  d +      g++i ++++  + i++n
  EFC38353.1 1416 SSySTLRNVELVGGFDYAIRLESSIDwggnnlkygasnIVIENCKIHGSGYHLIKIDSLcENVNIRNNELFDAGkrvrtgGSAIVCYDTFMTRIQDN 1512
                  3333444444444444444444444444444444444455555555555555555544345555555555544445555555555555555555555 PP

                  EEES-SS-SEE-T.T-S--EEES-EEESTT--SEE---TT---EEES-EEES-SSEEEE- CS
  Beta_helix   86 eitdnggsGiyln.yssnntienNiidnnagsGividdsssnvtvtnNtitnnkgaGiav 144 
                   i+++ g+ ++++ ++ n +ie+N+i+  +g+Gi                         v
  EFC38353.1 1513 YIHHTMGAAVMIKsGARNSIIERNYINKIYGAGIL------------------------V 1548
                  55555555555553355555555555555555554........................3 PP

  == domain 6  score: 28.6 bits;  conditional E-value: 2.4e-10
                  SEEE-SS-E.EEESEEEES-SS-SEEE-SSS-..EEES-EEES-SS-SEEE-TT..................-S-EEES-EEE---SEEE-TT--S- CS
  Beta_helix    2 gisingssnvtiknntisnsggyGiylrgssn.vvienneiannsgsGiyilgs..................snntisnntisdnngggialfgasn 79  
                  +i+++++  + i++n i+++ g++++++++ +  +ie+n+i++ +g Gi +                      n++++nn  +d  g gi l+ a+n
  EFC38353.1 1498 AIVCYDTFMTRIQDNYIHHTMGAAVMIKSGARnSIIERNYINKIYGAGILVGFYetgeyfsdpsqnplyyqaVNTIVRNNILNDISGAGIGLYSAKN 1594
                  78888888899****************9887769999******8888888888888889999999999999999999999999999*********** PP

                  -EEES-EEES-...SS-SEE-TT..............-S--EEES-EEESTT--SEE---TT............---EEES-EEES CS
  Beta_helix   80 nlienneitdn...ggsGiylny..............ssnntienNiidnnagsGividdss............snvtvtnNtitn 136 
                  +li  n+i++    +++Gi +n               ++n+ti nNii   ++  i+i+                n++v+ N+ ++
  EFC38353.1 1595 TLILFNTIWKAakdNQAGILINVvqtwvsnsyspivpCTNVTIMNNIIGTATERIIEIRTLTsyvddsvvggleGNMNVSFNIYYS 1680
                  ***********55544499998679999999*****************99997777666655222222344444455555555543 PP

  == domain 7  score: 76.9 bits;  conditional E-value: 3.3e-25
                  SEEE-SS-E.EEESEEEES-SS-SEEE-SSS-..EEES-EEES................-SS-SEEE-TT-S-EEES-EEE---SEEE-TT.--S-- CS
  Beta_helix    2 gisingssnvtiknntisnsggyGiylrgssn.vvienneian................nsgsGiyilgssnntisnntisdnngggialf.gasnn 80  
                  g++i++s++ ti++++i+++g+++i+l   ++ + i ++ei++                 sg+Gi+  +++++ is+n+i+d +g++i+++ g+ + 
  EFC38353.1 1915 GLMIDSSDV-TIRKVKIHDTGSDCIKLSPFTKrISILQSEIYHcgkrktyqagnpnqdsASGDGIRCVNVDDVFISRNYIHDLTGTAIKTQgGGLRA 2010
                  677777777.**********************7555579999999999999******9999999999999*********************99**** PP

                  EEES-EEES-SS-SEE-T.T........-S-........-EEES-EEESTT--SEE---TT---EEES-EEES-S...............SEEEE-T CS
  Beta_helix   81 lienneitdnggsGiyln.y........ssn........ntienNiidnnagsGividdsssnvtvtnNtitnnk...............gaGiavv 145 
                  +ie+n i + gg Gi+l  y        ++n          ++nNii n++g+G+ +++s+ n +v +Nti++++               +++++++
  EFC38353.1 2011 IIERNLILNIGGLGITLGfYeetsymdpTQNvyyyeaieGLVRNNIIVNVQGCGVGLYASK-NSRVLHNTIVSSAlsmqvpillaasphtINSVEIA 2106
                  ***************999889998888833344455555888*******************.*********************************** PP

                  T-SS--EEES-E. CS
  Beta_helix  146 gsssnvtvrnNti 158 
                  g+s+++ +++N+i
  EFC38353.1 2107 GQSNHNPMVKNNI 2119
                  ****999999986 PP

  == domain 8  score: 0.3 bits;  conditional E-value: 0.12
                  SEEE-TT--S--EEES-EEES-SS-SEE-TT-S--EEES-EEESTT..--SEE---TT---EEES-EEES CS
  Beta_helix   69 gggialfgasnnlienneitdnggsGiylnyssnntienNiidnna..gsGividdsssnvtvtnNtitn 136 
                  +++ia + ++n +++nn +   ++ Gi+ +  + +++++  + +n+   s + i++s+  ++ ++N++ n
  EFC38353.1 2102 SVEIAGQSNHNPMVKNNIVQVSES-GITQT-IYEIRVQDGDALDNSklDSNFNIYYSN-FNNYHGNSLAN 2168
                  578999999999999999999977.99665.556777777776766666777888888.55568887766 PP

  == domain 9  score: 52.0 bits;  conditional E-value: 1.5e-17
                  -E.EEESEEEES-SS-SEEE-SSS-.EEES-EEES......-SS-SEEE-TT-S-EEES-EEE---SEEE-TT.--S--EEES-EEES-SS-SEE-T CS
  Beta_helix    9 snvtiknntisnsggyGiylrgssnvvienneian......nsgsGiyilgssnntisnntisdnngggialf.gasnnlienneitdnggsGiyln 98  
                  +n++++ ++i+ +g+ ++++ +++n +++n+e+++      + g+G++   s n+  ++n+++d ++++i+l+ g+s+ +i +n i++ ++ Gi + 
  EFC38353.1 2399 DNIQVDRSIIHYCGTKCVFALNADNFTLTNSEVYDsgmrdpSEGEGVHAVVSHNFECKDNYVHDITADAIKLEgGSSHAIIAGNAISNADR-GILVG 2494
                  5689*************************************************************************************88.99998 PP

                  T.................-S--EEES-EEESTT--SEE---TT....---EEES-EEES-SSEEEE-TT-SS--EE CS
  Beta_helix   99 y.................ssnntienNiidnnagsGividdss....snvtvtnNtitnnkgaGiavvgsssnvtv 153 
                  +                 ++n ++ nNii+n  g Gi ++  +    + +t+ n +itn  ga+i+++++++ + v
  EFC38353.1 2495 GridnldlfeksnthlyeTYNSSVYNNIISNTFGVGIAMYGAKqceiYFNTILNTCITNTQGAAIHLASTKHRNLV 2570
                  779999999999999999999**********************888888888888888998****99999986654 PP

  == domain 10  score: 18.5 bits;  conditional E-value: 3e-07
                  EE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-.....SS-SEE-TT..........-S--EEES-EEESTT....--SEE---TT... CS
  Beta_helix   50 yilgssnntisnntisdnngggialfgasnnlienneitdn.....ggsGiylny..........ssnntienNiidnna....gsGividdss... 124 
                  +++++ n+ ++nn is+  g+gia++ga++  i+ n+i ++      g+ i+l +           ++++i nNi++n      g+ i id++    
  EFC38353.1 2509 HLYETYNSSVYNNIISNTFGVGIAMYGAKQCEIYFNTILNTcitntQGAAIHLAStkhrnlvitpVDSLVIVNNIVYNSDpsnaGAMIRIDEGLegf 2605
                  677889**********999**********************888776668888866766666666677********999999997777777766776 PP

                  .....---EEES-EEES-SSEEEE-TT-SS--EEES- CS
  Beta_helix  125 .....snvtvtnNtitnnkgaGiavvgsssnvtvrnN 156 
                        +v+++nN  ++nk  +++v g+++ +++++N
  EFC38353.1 2606 sasitGSVVMNNNLYYSNK-SSVFVDGRKA-TKFSGN 2640
                  6667778888888888887.9998999999.999998 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.2   0.0   3.6e-23   1.6e-19       1     135 [.     871    1000 ..     871    1007 .. 0.88

  Alignments for each domain:
  == domain 1  score: 70.2 bits;  conditional E-value: 3.6e-23
                   EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT. CS
  Pkinase_Tyr    1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk. 95  
                   l++++kl+eG  G V+ g++       + +Va+K+lk+++    +e + +e++++ +l+hp i+ ++g+ + +++ +++tey++gG+L+k + ++ 
   EFC38353.1  871 LTIERKLAEGGQGVVYVGNWG------SSTVAIKSLKSDQ----SEGFETEVSLLASLRHPCILTFYGISITNDSKYMITEYLSGGSLEKLIYSSk 956 
                   67899****************......899******6544....466*******************************************998873 PP

                   .CTTTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST-SG.GGEE CS
  Pkinase_Tyr   96 .ekekltlkdllsfalqvAkGmeyLeskk..lvHrdlaa.rNvL 135 
                    ++ +lt+ +++++  ++A Gm+yL++ +  ++Hrdl+   NvL
   EFC38353.1  957 tKTIALTYMEKINILKDIAIGMNYLHTLTppIIHRDLSVlSNVL 1000
                   3455689999****************97666******8526666 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.3   0.0   4.2e-20   1.9e-16       3     130 ..     873    1000 ..     871    1008 .. 0.86

  Alignments for each domain:
  == domain 1  score: 60.3 bits;  conditional E-value: 4.2e-20
                  EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS- CS
     Pkinase    3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsl 95  
                   ++kl eG+ G+Vy +   + + +vA+K +k ++ +      + +E+++l++l+hp i+++y++  ++d+ y+++ey++gg+l++l+     +  +l
  EFC38353.1  873 IERKLAEGGQGVVYVGN--WGSSTVAIKSLKSDQSEG-----FETEVSLLASLRHPCILTFYGISITNDSKYMITEYLSGGSLEKLIYssktKTIAL 962 
                  679999********998..99*********9987766.....447*****************************************99775444447 PP

                  -HHHHHHHHHHHHHHHHHHHHTT..EE-SS-S.GGGEE CS
     Pkinase   96 seeeakkiakqilegleylHskg..iiHrDlK.peNiL 130 
                  +  e  +i+k i+ g++ylH     iiHrDl   +N+L
  EFC38353.1  963 TYMEKINILKDIAIGMNYLHTLTppIIHRDLSvLSNVL 1000
                  7778889*************88778*****95235665 PP

>> HOCHOB  Homeobox-cysteine loop-homeobox
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.1     0.084   3.8e+02      27      64 ..      96     134 ..      79     163 .. 0.67
   2 ?    8.2   0.0   0.00086       3.9      48     118 ..     373     446 ..     368     448 .. 0.87
   3 ?   -2.0   0.0       1.3   5.6e+03       6      27 ..     916     937 ..     912     939 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.084
      HOCHOB  27 YeqvfkRfselRllk.kekCeknDtCekvakyfeskeky 64 
                  +q++ R +   + + ++ C++nD C   +++f+s + +
  EFC38353.1  96 ASQIIVRLMMKNTSNtEAICSENDPCYSFSQLFDSMKLL 134
                 4677777665554441457*********99999876643 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00086
      HOCHOB  48 nDtCekvakyfeskekydglldektlellkeeFeklieagkv..leigyiHl.vvekvelppkvvreqykeWye 118
                  D+C+ v+++f+ + ++ ++   k+l++ + eF++ ++++ v   ++  i l +++++ + + +vr+qy+++++
  EFC38353.1 373 SDSCTIVNSFFQRSGSILNIRGVKNLNIANVEFDENVQTEAVsnAQTSPIELkIIDNLLMINVTVRNQYSNYLN 446
                 69*******************************9887766551156777888899***************9986 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1.3
      HOCHOB   6 eknrHPsiqemikiseetgvkY 27 
                  + rHP i +   is + + kY
  EFC38353.1 916 ASLRHPCILTFYGISITNDSKY 937
                 6679***********9999888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (3072 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       742  (0.0413855); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.43u 0.35s 00:00:01.77 Elapsed: 00:00:00.55
# Mc/sec: 16772.65
//
Query:       EFC38354.1  [L=413]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-15   57.2  25.8    1.3e-15   57.2  25.8    2.0  2  MFS_1            Major Facilitator Superfamily
    8.8e-08   31.4  33.0    1.1e-07   31.1  33.0    1.0  1  Sugar_tr         Sugar (and other) transporter
  ------ inclusion threshold ------
       0.18   12.0   7.9       0.84    9.9   0.4    3.3  3  Bacteriocin_IId  Bacteriocin class IId cyclical uberolysin-li


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.2  25.8   2.2e-19   1.3e-15      37     326 ..       2     337 ..       1     342 [. 0.74
   2 ?    1.7  10.7     0.017     1e+02     215     294 ..     314     401 ..     303     409 .. 0.66

  Alignments for each domain:
  == domain 1  score: 57.2 bits;  conditional E-value: 2.2e-19
       MFS_1  37 lltlyalgaavaslplGrlsdrfGrrrvlllglllfalglllllfa.....sslw.lllvlrvlqGlgagalfpagaaliadwfpkeergraigllsag 129
                 ++ +y+++ + as+ +++l+ +fG r  ++l + l ++g+++ +++      +++ + + + ++++l++ +++ ++  l+  wf ++er+ +  +  ++
  EFC38354.1   2 MTLIYMILNIPASITGSFLTKKFGLRFGMILVAWLNFIGGCIRCLGykkgnETFFwIAFGGQIFCALAQPLALNSATLLAFNWFGEKERTVVSVVSVLM 100
                 6778***********************888888888888566665444556666669**********************************99888888 PP

       MFS_1 130 fslGailgpllggllasslg............Wravfyilaivsllafvlfllllpeepperkrkspkeee............................ 188
                 + +G     ++g+ l+++++            + ++ +++a + ll++v   +++ ++pp+++   +  ++                            
  EFC38354.1 101 AIFGGGASFAIGPSLLTAGStdmsgsefgmltFLGAQVLIATMNLLLVV---VFFKANPPTPPILLKSSKSeetiasinsepamedessrkndetlsli 196
                 8888888888888888888877778888777777777777777777766...67766665555555555555889999999999999999666666666 PP

       MFS_1 189 kgtgpaplvpawkallkdpvlwillialllfffgfsglltllplylqevlgls...glllaglllallalvgailallagrlsdrlgrrrrlllallll 284
                     ++ ++++ k++ +d ++  l +a+ ++  +fs++ + l     +  g++   g     +++++++++g   +++ g l d+++r + + ++ +ll
  EFC38354.1 197 DIGTKQTFFEGVKSIITDIHFINLALAFTFVNSVFSSFASILNQV-IQSKGYTpfdG-SKFNIIMMVCSVIG---SIVMGILFDKTKRYKLIAMMSSLL 290
                 55555555558********99755555555556888888888885.89999999995.44444599999999...99********99977777777777 PP

       MFS_1 285 llaalglallavtssavllllvlvl.....iGfglgfvfpsllalas 326
                 +++ ++++ + ++++ + +l+++ l     iG+++  + p+++ +++
  EFC38354.1 291 ATFGFACFATVMIWNRSDFLFGMGLfshlfIGLFAIPTLPLIAQMIA 337
                 77777777777777777777733331233355555555555555554 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.017
       MFS_1 215 alllfffgfsglltllplylqevlgls.......glllaglllallalvgail.allagrlsdrlgrrrrlllallllllaalglall 294
                 +l++  f+  ++  +lpl++q+  + +       ++ lag++  ++a + +i+  ++  ++s+ +++  +l++ ++ +l+++++l l+
  EFC38354.1 314 GLFSHLFIGLFAIPTLPLIAQMIADVTfpvlpstSAALAGGFGTVCAGIYLIIiNFIQEYVSNETSSIVILWMDVGMMLMCFIMLSLF 401
                 2222233333367777777777777777788888446666666666666666657777777788888888888888888888888776 PP

>> Sugar_tr  Sugar (and other) transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.1  33.0   1.8e-11   1.1e-07      51     434 ..       2     399 ..       1     410 [. 0.76

  Alignments for each domain:
  == domain 1  score: 31.1 bits;  conditional E-value: 1.8e-11
                 HHHTHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHH-TTTT...SS-TGGGGGHHHHHHHHHHHHHHHHHHHHTTS-SCCHHHHHHHHHHH CS
    Sugar_tr  51 ivsiflvGaiiGslfagllgdrfGRkkslliaavlfvigavlqaaakgk...nsvevlivgRvlvGigvGlasvlvPmyisEiApkklRgalvslyqla 146
                 ++ i+++  i  s+++++l+++fG + +++ +a l +ig+++  +  +k   + +++ + g++++ ++  la + +++++     +k R  + ++  l+
  EFC38354.1   2 MTLIYMILNIPASITGSFLTKKFGLRFGMILVAWLNFIGGCIRCLGYKKgneTFFWIAFGGQIFCALAQPLALNSATLLAFNWFGEKERTVVSVVSVLM 100
                 678999999********************************99888877778889******************************************** PP

                 HHHHHHHHHHHHHHHHTSS-......TTHHHHHHHCCHHHHHHHHHHGGGS....---HHHHHHTT-HHHHHHHHHH.HHHC..HHHHHHHHHHHHHHH CS
    Sugar_tr 147 itfGilvaaifglglnktsn......adgwrillglqlvpallllilllfl....PESPrylvekgkeeeakevlak.lrge..edadrelaeekdsle 232
                  +fG   ++ +g  l + ++      + g+  +lg q+++a + l+l++++    P +P  l++  k ee+ +++         ++ +r+ +e  + ++
  EFC38354.1 101 AIFGGGASFAIGPSLLTAGStdmsgsEFGMLTFLGAQVLIATMNLLLVVVFfkanPPTPPILLKSSKSEETIASINSeP--AmeDESSRKNDETLSLID 197
                 ***998888888777655555789889999999**99999977665553322455899999999999999999888833..344778888888888888 PP

                 HHHH.....HTTHHHHSH...HHHHHHHHHHHHHHTTHHHHHHHTTTHHHHSS-THH......HHHHHHHHHHHHHHHHHHHHHHHHS-SHHHHHHHHH CS
    Sugar_tr 233 aeqeeekaswkellssktvrqrlligvvlqifqqltGinaimyysptifenlglsks......llvtiivgvvnfvatfvaiflvdrfGRRtllllGaa 325
                  + +      +++++   v+  ++ +  ++++  +t +n+++    +i++++  sk         ++ii++v  ++ ++v   l d++ R +l  + ++
  EFC38354.1 198 IGTK------QTFFEG--VKSIITDIHFINLALAFTFVNSVFSSFASILNQVIQSKGytpfdgSKFNIIMMVCSVIGSIVMGILFDKTKRYKLIAM-MS 287
                 8843......456666..3355556667777777777777777666666666666666666999***********************877666543.33 PP

                 HHHHHHHHHH...HHHHTTSS...CHHHHHHHHHHHHHHHTTTTHHHHHHHHHHS....HTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHT-HHH CS
    Sugar_tr 326 gmaicfvilg.ivalllvakskaasivaivfialfialfalgwgpvpwvlvsElf....pqsvRskalaiavavnwlanflisllfpiiteaigggyvf 419
                   ++ f + +   +++++ ++    +++  f  lfi lfa+   p+++ +++++     p+   ++a  + +++  +  ++i+++  ++ +  +  ++ 
  EFC38354.1 288 SLLATFGFACfATVMIWNRSD--FLFGMGLFSHLFIGLFAIPTLPLIAQMIADVTfpvlPSTSAALAGGFGTVCAGIYLIIINFIQEYVSNETSSIVIL 384
                 333333444433455555553..7999**************************8622224555555555566666666666666666666666677777 PP

                 HHHHHHHHHHHHHHH CS
    Sugar_tr 420 lvfaglavlfiifvf 434
                 ++ +g++++ +i+  
  EFC38354.1 385 WMDVGMMLMCFIMLS 399
                 777777777666554 PP

>> Bacteriocin_IId  Bacteriocin class IId cyclical uberolysin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.4   0.00014      0.84      23      46 ..      91     114 ..      87     120 .. 0.85
   2 ?   -1.5   0.2      0.51     3e+03      24      34 ..     258     268 ..     252     292 .. 0.68
   3 ?    5.2   0.1    0.0039        23      38      67 .]     356     385 ..     343     385 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00014
  Bacteriocin_IId  23 tvasiisiitailsaGailaigas 46 
                      tv+s++s+++ai ++Ga  aig s
       EFC38354.1  91 TVVSVVSVLMAIFGGGASFAIGPS 114
                      89***************8887765 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.51
  Bacteriocin_IId  24 vasiisiitai 34 
                      ++++ s+i++i
       EFC38354.1 258 IMMVCSVIGSI 268
                      33444444444 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0039
  Bacteriocin_IId  38 GailaigasaviatvkkkikkngkaqAiaW 67 
                      G++ a+   ++i+ +++++++     +i+W
       EFC38354.1 356 GTVCAGIYLIIINFIQEYVSNETSSIVILW 385
                      5577776777************99999999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (413 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1043  (0.0581739); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2438.04
//
Query:       EFC38355.1  [L=618]
Description: TCCD-inducible-PARP-like domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-26   93.6   2.5    1.1e-26   93.6   2.5    3.0  2  PARP           Poly(ADP-ribose) polymerase catalytic domain
    8.1e-15   55.2   0.1    8.1e-15   55.2   0.1    1.9  2  Ank_2          Ankyrin repeats (3 copies)
    2.3e-11   42.9   0.4    6.9e-05   23.0   0.0    3.1  2  Ank_3          Ankyrin repeat
    6.3e-11   42.3   0.2    0.00043   20.5   0.0    2.7  2  Ank_5          Ankyrin repeats (many copies)
    1.1e-10   41.4   0.3    0.00054   20.3   0.0    2.6  2  Ank            Ankyrin repeat
    8.4e-09   35.8   0.0     0.0011   19.5   0.0    2.8  2  Ank_4          Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> PARP  Poly(ADP-ribose) polymerase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   1.3      0.28   8.3e+02     125     164 ..     311     356 ..     303     389 .. 0.50
   2 !   93.6   2.5   3.7e-30   1.1e-26      15     194 ..     448     616 ..     429     617 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.28
                 SS--T.GCCGGTT-SEEEE-EEEEE...GG.EEETT..E--S-EEE CS
        PARP 125 tkady.lekakkgkksvkgkgktep...esivekdg..vPlgkssa 164
                 +++++   k+k++k++ ++k+k+++   ++ ++ ++  +  +k+++
  EFC38355.1 311 SEQSIkNIKKKEKKQFSNSKSKKSEeisKKLQNLKQkeIEIEKMEK 356
                 4455533445555555555555555344222222223344444422 PP

  == domain 2  score: 93.6 bits;  conditional E-value: 3.7e-30
                 S-TTTTEEEEEEEEEEEEET...THHHHCGCCGG.....SS-EEEEEEEE-GGGHHHHHHH-S--S-TTS-GGGSTTSSSEEEBSSHHHHHGGG--BSS CS
        PARP  15 ldsthayklkileifrvqre...geaerfqekkk.....lrnrrlLfHGsrltnvasilsqGLriappeapvtGymfGkGiYfAddaskSanYcktsek 105
                 +++  +y+++i  ++ vq+e   + +++f++ k      ++n+++L+HG++ ++v  i ++G+  + ++a+++G  fG GiYfA+  skS +Yc++ ++
  EFC38355.1 448 MNHLISYQDSINSLQ-VQTEnisKTSKTFEWMKTiglnsNMNEKYLWHGTKPEFVNTIAEHGF--DERVANLNG-LFGAGIYFAEYCSKSDQYCTP-DH 541
                 444444555544332.2333000345567776668887799**********************..*******98.5*******************9.66 PP

                 S-EEEEEEEEEE--SEEEESS--TGCCGGTT-SEEEE-EEEEEGG.EEETT....E--S-EEE-S--SSSEEE-EEEESSGGGEEEEEEEEEE CS
        PARP 106 kgsglllLaeValGdikeltkadylekakkgkksvkgkgktepesivekdg....vPlgkssatkyesseleyneyvvydkeqvrlkYLlevk 194
                 +++  llL++V +G   ++tk+            v  ++++ p    e  g    v   +s+  ++++s+ +y+e++vydk q+++++++++k
  EFC38355.1 542 SNEYTLLLCRVVMGRQIHFTKQ------------VMNNQRRPP----EISGsnnrVY--DSVIGQSNTSTNSYREFIVYDKCQCYPEFIIKYK 616
                 777779*********3333332............222222222....2222210122..2244556666688*******************97 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.2   0.1   2.7e-18   8.1e-15       3      79 ..      10      98 ..       8     101 .. 0.80
   2 ?   -2.7   0.4       3.2   9.6e+03      11      48 ..     234     268 ..     226     276 .. 0.52

  Alignments for each domain:
  == domain 1  score: 55.2 bits;  conditional E-value: 2.7e-18
       Ank_2  3 lAakngnlelvklLlegadpn.k.ngktaLhyAakngnleivklLleh....ad.....ndgrtpLhyAarsghleivklLlek.gadi 79
                +Aa++g+ + ++   ++ d+n +  g t L++A++ng+leivklLl+     ++     ++ +tpL++A+ +ghleivk Ll++ +++i
  EFC38355.1 10 YAAEKGKIDEFNNYFNEQDVNkSqRGVTMLYIACQNGHLEIVKLLLSCktidVNlsttyYTFMTPLYIACHYGHLEIVKELLQHpNIEI 98
                799998665555555899999736**********************95576733445656677*******99**********8756666 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3.2
       Ank_2  11 elvklLl.egadpnkngktaLhyAakngnleivklLleh 48 
                 +l++ L  ++++++    +  h++++n+  + ++++le+
  EFC38355.1 234 NLIEKLTsNNYNIE----NNEHLSTINNLMNNIRTILEF 268
                 45566654444443....223555555544445555554 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.1   2.1e-06    0.0064       2      30 ..      35      63 ..      34      64 .. 0.86
   2 !   23.0   0.0   2.3e-08   6.9e-05       3      30 ..      72      99 ..      71     100 .. 0.94

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 2.1e-06
       Ank_3  2 GetpLhlAarsgnleivkfLlenkgadvn 30
                G t+L++A+ +g+leivk+Ll  k +dvn
  EFC38355.1 35 GVTMLYIACQNGHLEIVKLLLSCKTIDVN 63
                78*******************94467776 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 2.3e-08
       Ank_3  3 etpLhlAarsgnleivkfLlenkgadvn 30
                +tpL++A+++g+leivk Ll++++++++
  EFC38355.1 72 MTPLYIACHYGHLEIVKELLQHPNIEID 99
                69********************999986 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   1.4e-07   0.00043       7      51 ..      26      66 ..      21      71 .. 0.76
   2 !   19.8   0.1   2.5e-07   0.00074      17      38 ..      72      93 ..      60      97 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.4e-07
       Ank_5  7 advnrldgggntpLhvAakygaadvvrlLlargadlnltdsrGlt 51
                ++  ++ ++g+t L +A+ +g++++v+lLl    ++++ d + +t
  EFC38355.1 26 EQDVNKSQRGVTMLYIACQNGHLEIVKLLL----SCKTIDVNLST 66
                555666789*********************....66665555444 PP

  == domain 2  score: 19.8 bits;  conditional E-value: 2.5e-07
       Ank_5 17 ntpLhvAakygaadvvrlLlar 38
                +tpL +A++yg++++v++Ll +
  EFC38355.1 72 MTPLYIACHYGHLEIVKELLQH 93
                5*******************55 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.1   6.2e-07    0.0018       2      29 ..      35      64 ..      34      67 .. 0.84
   2 !   20.3   0.0   1.8e-07   0.00054       3      27 ..      72      96 ..      72     101 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 6.2e-07
                SBBHHHHHHHHTTHHHHHHHH.TT.TSTTC CS
         Ank  2 GnTPLHlAatngkkriiklLL.hG.Anlna 29
                G T L +A++ng+++i+klLL +   ++n+
  EFC38355.1 35 GVTMLYIACQNGHLEIVKLLLsCKtIDVNL 64
                99*******************654467775 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 1.8e-07
                BBHHHHHHHHTTHHHHHHHH.TTTST CS
         Ank  3 nTPLHlAatngkkriiklLL.hGAnl 27
                +TPL +A+++g+++i+k+LL h  n+
  EFC38355.1 72 MTPLYIACHYGHLEIVKELLqHP-NI 96
                7*******************553.54 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   3.6e-07    0.0011      25      55 .]      27      55 ..       9      55 .. 0.81
   2 !   13.1   0.0   3.6e-05      0.11       2      27 ..      72      98 ..      58     109 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 3.6e-07
       Ank_4 25 adinaqdnrsGetalhiAakrgnveilklLl 55
                +d+n++   +G t l+iA+++g++ei+klLl
  EFC38355.1 27 QDVNKS-Q-RGVTMLYIACQNGHLEIVKLLL 55
                577776.4.49*******************8 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 3.6e-05
       Ank_4  2 ltaLhyaaisgrlelvrlLlek.gadi 27
                +t+L  a+++g+le+v+ Ll++ +++i
  EFC38355.1 72 MTPLYIACHYGHLEIVKELLQHpNIEI 98
                566666777777777777776666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (618 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3823  (0.21323); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.88u 0.31s 00:00:01.19 Elapsed: 00:00:00.50
# Mc/sec: 3744.71
//
Query:       EFC38356.1  [L=644]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-08   34.4   3.3    6.5e-08   32.9   3.3    1.8  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.9   3.3   3.6e-12   6.5e-08       2     109 ..     486     628 ..     485     632 .. 0.94

  Alignments for each domain:
  == domain 1  score: 32.9 bits;  conditional E-value: 3.6e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS................. CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke................. 83 
                 l+++l d++  + F  F e++++ enl  w  +e f+++ +++ + k++ +I+++yl ++sp eln++++++++ e+  + +                 
  EFC38356.1 486 LSKILFDKKWNEEFLIFSEKSYCPENLMCWNSIEIFRES-SEKLRRKHIISILETYLLEGSPLELNVQRQIFNNFENITSIVrsikaqeaelkrlaeen 583
                 679999999******************************.99999999**************************999887779999************* PP

                 ....................STTTTTTHHHHHHHHHHHHHHHHHHH CS
         RGS  84 ....................qpsrklfeeaqeevfellekdsypkF 109
                                     q   +lf+ +q+++   ++ d++ +F
  EFC38356.1 584 nkvvgtavvalqrrksmkiiQIPTNLFDSIQKHCEINMA-DCFDRF 628
                 **********************************99997.677777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (644 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1371  (0.0764683); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.48
# Mc/sec: 4017.83
//
Query:       EFC38357.1  [L=559]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.6e-10   39.8   3.1      1e-08   35.4   3.1    2.4  1  RGS         Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.061   13.8   0.9       0.13   12.7   0.9    1.5  1  Arrestin_C  Arrestin (or S-antigen), C-terminal domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.4   3.1   1.1e-12     1e-08      12     101 ..     414     535 ..     404     554 .. 0.77

  Alignments for each domain:
  == domain 1  score: 35.4 bits;  conditional E-value: 1.1e-12
                 HHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS........................... CS
         RGS  12 rslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke........................... 83 
                    F  F e++++ enl  w ave+fk+a +++ + k +k+I+++yl ++sp elni+++++++ e+                                
  EFC38357.1 414 NDEFLLFSEKSYCPENLMCWNAVEQFKRA-PEKLRRKLIKVIMETYLIEGSPLELNIQRNMFNNFEDISAITdsikrqenemkrlvaennivvgtikkr 511
                 5679999**********************.99999999*************************999865444557776766666666666666666666 PP

                 ......STTTTTTHHHHHHHHHHH CS
         RGS  84 ......qpsrklfeeaqeevfell 101
                       + ++++++++q+++   +
  EFC38357.1 512 rsmkmiSIQPNILDRVQKQCEVNM 535
                 666666555556666666555555 PP

>> Arrestin_C  Arrestin (or S-antigen), C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.9   1.5e-05      0.13      24     110 ..     126     229 ..     124     257 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.5e-05
                 EEEEEEE-SSSEEEEEEEEEEEEEEEESS..SEEEEEEEEEE.EEE---.................B-TTEE.EEEEEEE.----B--.---S---EEE CS
  Arrestin_C  24 vtvkidndskkkvkkikvslvqhvdvcafnrsnkkeknvvak.sdsvkv.................tsaakdkletevelqiPeeltp.ssarnvelik 103
                 +++ki n   k++k++++s+   v++ a ++s+   ++ v++ ++s +v                  ++++ +le +v++++P  +t+   + +++++ 
  EFC38357.1 126 LKIKIGNREMKDLKNVELSVMSSVQIDAVSSSTETSESNVSQtNVSFSVesnatgshsgtlesgnqMVNQQVTLEDSVSVNQP-GITKwENF-EKKVLM 222
                 679999***********************995554444444447777776677788888888888888888888888888999.88885333.455444 PP

                 EEEEEEE CS
  Arrestin_C 104 vsYklkv 110
                   Yk+ +
  EFC38357.1 223 KVYKFLI 229
                 4455544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (559 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1335  (0.0744604); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.34s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 3218.12
//
Query:       EFC38358.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-83  280.7   0.0    2.3e-83  280.5   0.0    1.0  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  280.5   0.0   1.3e-87   2.3e-83       6     460 ..      49     501 ..      45     504 .. 0.87

  Alignments for each domain:
  == domain 1  score: 280.5 bits;  conditional E-value: 1.3e-87
                 EHHCCHCHHHHTTTCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGH.HHHHHHHHHHH CS
        p450   6 plplvgnllqlgrkeelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfang.ekwkklRrflt 103
                 ++p++  +l l ++e l +++  +     +++++   ++p v++s+p++ ke +i+kg+ f++   + +++    +f + ++l+a+  ekwkk+ +++ 
  EFC38358.1  49 RIPFLSTHLYLTSDEDLDKACLLYGDAETQTLSIATSTTPLVFISDPKMLKEYFITKGHLFEKP-GYEVVN----FFGEDNILTATNtEKWKKHYKICS 142
                 677777777777777777777777777788999*************************888885.666666....5888888888888*********** PP

                 HHHTSHSTT.THHHHHHHHHHHHHHHHHCCCCHCS.EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHH.HHHHHHHHHHHCHHHHCCCCCHHHT CS
        p450 104 ptltsfgkl.sleelveeeaedlveklrkkagess.elditellskaaldvigsilFgarfdlledeklselv.kaveelssllskssvqllllfpllk 199
                 +++t + +l  + ++ +++ + l e ++++ +e++  +  ++  s+ +ldv+g+ +F++ f+ + ++++ ++  + +e+l+s  +  s+ ++  +p+l 
  EFC38358.1 143 AAFTPK-NLmYVCKVADKSCDLLFEIWNERLKENGsMILDVNEYSNLTLDVLGKAAFNIDFGFYSNNEEGRYFrQSMEKLISPQAVLSFAFFGNIPFL- 239
                 ****99.99899**********************9866667778999****************99998766541445566554444444555555533. PP

                 CCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC....SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHH CS
        p450 200 ylptkllrklkeavkklkdlldklieerretldsa....kksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPe 294
                 + + +    +++a++  +d+ldk+ie+r++ l++     +++  d+l +l+ a    k+e ++++++l+ ++l l +aG++Tt+ tlsw+ y L k+Pe
  EFC38358.1 240 FKLANRVMGVQAATDHCSDYLDKIIEQRKKLLSTGeildTDEGSDLLTLLVGAN--VKEE-TITNNQLKSNTLLLSTAGHETTAKTLSWVSYRLSKHPE 335
                 44555566678899*********************999988999*******996..6666.8************************************* PP

                 HHHHHHHHHHHHCCTTTT-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTS CS
        p450 295 vqeklreEidevlgdkreptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRFldekg 393
                 +q+kl +E+devl++ r+pty+dl +lpy++a+i E+LRl p+v+ +l R +tk+++++ y+ipkGt+v+ +++ +++++++++n++eF peRFld k+
  EFC38358.1 336 IQSKLWKEVDEVLQG-RNPTYADLPSLPYVNAIITESLRLNPPVY-HLGRIATKNLTLGKYDIPKGTMVQAFMSRVQQREDIWENAKEFIPERFLDPKV 432
                 *************88.58***************************.***************************************************** PP

                 .CTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSC.SSEEESSSSE CS
        p450 394 .nskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileks.glllppkpik 460
                  +s +++f + +F+ G R+C+G+++A++e   +l +l q++e++l +++++ p    +  +++p+++ k
  EFC38358.1 433 kDSYQHNFTYAAFSLGNRQCLGKHFAILEAATILCKLAQKYEFKLLNDESVDPVGVFKlPVAKPTSNMK 501
                 87789****************************************999988876655555666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       814  (0.0454013); expected 358.6 (0.02)
Passed bias filter:                      675  (0.0376485); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 2941.43
//
Query:       EFC38359.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.4e-06   26.7   0.0    1.8e-05   24.4   0.0    2.0  1  Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family


Domain annotation for each model (and alignments):
>> Exo_endo_phos  Endonuclease/Exonuclease/phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.0   9.8e-10   1.8e-05      21     206 ..      48     311 ..      35     339 .. 0.67

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 9.8e-10
                    HHHHHHHHC..TTSEEEEEEEBSCTCHHHHHHHHH.........TTCEEEEECCH......................................... CS
                    xxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxx......................................... RF
  Exo_endo_phos  21 rladlltay..daDvlgLQEvdddelsriplllal.........ggflgasstsp......................................... 64 
                    ++++++++   d Dv++LQEv+ ++ s + +  +                    +                                         
     EFC38359.1  48 NVKKIIETIpkDLDVVFLQEVWLQSHSHLIAEELKssypysfhgH---------Kevlneasctddsfhrfalpflhcvrennltlswttlgpcae 134
                    4666665554456************99998888865433333330.........256777777777777788888888888888888888899999 PP

                    ....................................ECSSSTTSSEEEEEECSTEEEEEEEEEEETSSSSGCEEEEEEEEEEEEEEECCCHHGHHH CS
                    ....................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos  65 ....................................tgggggggnggavlsrfpltslfrrtfiefndlvaalrreplaakleqlniashrdhdlv 124
                                                          + ++g ng++vls+ p+ +  +++++                                
     EFC38359.1 135 flsraaygnfkciscvltsivenknmancytpghtgQEFLYDGSNGLMVLSKTPISRANYTSYPS------------------------------- 199
                    9999999999999999999999999999999999999******************8886665555............................... PP

                    HHHHHHHHHHHHHHHHHHTTSEEEE................................................EEE-SSSTSGGGBSCGHHHHHHC CS
                    xxxxxxxxxxxxxxxxxxxxxxxxx................................................xxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 125 rdlqllalllqvealnadrgapviv................................................aGDfNarpsdddsrvlrtrglal 172
                                           ++                                                +GD+N+             g ++
     EFC38359.1 200 -----------------------FLlsrgllemcinglyimeshfpfnfgidlpvmyqpefsrmvimkrpnilVGDLNS-------------GPMT 259
                    .......................44477777777777777888888888888888888888888888888888999999.............2222 PP

                    TTTH.....H.............SSCESCETTTTTTTTTTTEB-BEEEEEEC CS
                    xxxx.....x.............xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Exo_endo_phos 173 apap.....v.............glyllgggptptyvtraggsrlDrilasp 206
                     p+      +               ++l+++       +  +  +D+i++ +
     EFC38359.1 260 QPEGyetlaGygyqsidpnkatfCVNGLNWESGDCSDDPERNTGMDHIMVDK 311
                    2222222221334444555555555555555555555555555557776664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       313  (0.0174578); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 2197.95
//
Query:       EFC38360.1  [L=106]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.074   13.6   0.7       0.27   11.8   0.7    2.0  1  Inhibitor_G39P  Loader and inhibitor of phage G40P


Domain annotation for each model (and alignments):
>> Inhibitor_G39P  Loader and inhibitor of phage G40P
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.7   1.5e-05      0.27      14      56 ..      31      73 ..       8      83 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.5e-05
  Inhibitor_G39P 14 kaaYPrfyngrskkenk....mvvevWadllkdydyklvskalkali 56
                    +  YP +       e +     +v++W  +l++y++ +v  +l  +i
      EFC38360.1 31 STDYPDD----KLSELNffdgGMVKLWIFMLENYSLTMVTIVLPFVI 73
                    4444655....233332111169***************998876555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (106 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       490  (0.02733); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.33s 00:00:00.87 Elapsed: 00:00:00.53
# Mc/sec: 600.58
//
Query:       EFC38361.1  [L=162]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-41  140.5   1.0    1.8e-41  140.1   1.0    1.2  1  GSHPx     Glutathione peroxidase
    2.5e-09   37.1   0.2      4e-09   36.4   0.2    1.5  1  AhpC-TSA  AhpC/TSA family
    2.5e-06   27.3   0.2    6.6e-06   25.9   0.2    1.8  1  Redoxin   Redoxin


Domain annotation for each model (and alignments):
>> GSHPx  Glutathione peroxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  140.1   1.0     3e-45   1.8e-41       1     108 []       6     113 ..       6     113 .. 0.99

  Alignments for each domain:
  == domain 1  score: 140.1 bits;  conditional E-value: 3e-45
                 GGGBEEEBTTSSEEEGGGGTTSEEEEEEEESSSTTHHHHHHHHHHHHHHGGGTEEEEEEEE-TTTT---S-GGGHHHTSSHTTT-SSEEB--BBSSSTT CS
       GSHPx   1 iyelsakdidgekvkleklrgkvvlivnvaskCglteqykeleelqkrykdkglvilgfPCnqfgkqepgsdeeikkfrqgkyevtfellekievnGek 99 
                 +y++ + d +g++vkl+ ++gkvv++vnvas Cg+t+qy  l++l+++ykd+gl il+fPCnqf  qe gs+eei +f+ +ky+vtf+++ k++vnG +
  EFC38361.1   6 FYSFVVPDAQGNDVKLSDYKGKVVMVVNVASSCGKTPQYAGLQKLYEKYKDQGLEILAFPCNQFAFQERGSNEEICTFTRDKYKVTFKMFAKTTVNGGD 104
                 799************************************************************************************************ PP

                 B-HHHHHHH CS
       GSHPx 100 edplykflk 108
                   ply++lk
  EFC38361.1 105 TIPLYQYLK 113
                 *******98 PP

>> AhpC-TSA  AhpC/TSA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.4   0.2   6.7e-13     4e-09       5      88 ..       6      96 ..       3     142 .. 0.75

  Alignments for each domain:
  == domain 1  score: 36.4 bits;  conditional E-value: 6.7e-13
                ----EEESTTCEEEECHHHTTSEEEEEEESTST-CCHHHHHHHHHHCHHHCCCTTEEEEEEESSSCH........HHHHH.HHH-H.SSEEEE CS
    AhpC-TSA  5 apdfelknadgetvslsdykgkpvvlffypkdwcpvCttelpalaklyeefkergvevigvsvdspe........shkkf.iekeslnfplls 88
                + +f +++a+g++v+lsdykgk+v+++ +++ +c  +  +   l+klye++k++g+e+++  +++ +        ++  f  +k++++f++++
  EFC38361.1  6 FYSFVVPDAQGNDVKLSDYKGKVVMVVNVAS-SCGKT-PQYAGLQKLYEKYKDQGLEILAFPCNQFAfqergsneEICTFtRDKYKVTFKMFA 96
                56799************************99.99887.67889*****************998876655555555333330344456666666 PP

>> Redoxin  Redoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.2   1.1e-09   6.6e-06       8      82 ..       8      78 ..       2     160 .. 0.83

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 1.1e-09
                --ECCEETTCEEEEEHHHHTTSEEEEEEESTTT-HHHHHTHHHHHTHHHHHHCSTTTEEEEEESSSHHHHHHHHH CS
     Redoxin  8 dftlplaatdgnsvslsefkgkkvvvnfvpgafcPtCsaehpyleklaellkekgvdvvavvadndafvkefwgk 82
                +f+ p+   +gn+v+ls++kgk+v+v+ v++  c+   + +  l+kl+e++k+ g +++a  +++ af+ +  ++
  EFC38361.1  8 SFVVPD--AQGNDVKLSDYKGKVVMVVNVAS-SCGKTPQYA-GLQKLYEKYKDQGLEILAFPCNQFAFQERGSNE 78
                567767..99*********************.999855555.****************99988888886554444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (162 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       627  (0.0349713); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1019.55
//
Query:       EFC38362.1  [L=971]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.038   14.0   0.2        1.3    9.1   0.1    2.9  2  Mistic    Membrane-integrating protein Mistic


Domain annotation for each model (and alignments):
>> Mistic  Membrane-integrating protein Mistic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0     0.019   3.3e+02      16      33 ..     627     644 ..     622     655 .. 0.77
   2 ?    9.1   0.1     7e-05       1.3      37      68 ..     681     712 ..     674     717 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.019
                 HHHHHHH--SSS-SS-SS CS
      Mistic  16 ldafieLYNeseedkpli 33 
                 +d+fi+LY +se  +   
  EFC38362.1 627 IDQFIDLYTKSEMRNTAF 644
                 699******999876655 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 7e-05
                 HHHHHHHHHHHHHTSSSS-HHHHHHHHHHHHH CS
      Mistic  37 eevleaiekAkekYGeevvnkKiNtivkevLs 68 
                  +vl++i + ++ +G +v+++ +N+iv+++L 
  EFC38362.1 681 LNVLQEIVAVTKHFGIQVLEECLNAIVEDMLV 712
                 57999*************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (971 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       931  (0.051927); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.30s 00:00:01.10 Elapsed: 00:00:00.50
# Mc/sec: 5805.67
//
Query:       EFC38363.1  [L=1349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-44  152.8   0.7    3.5e-44  151.2   0.5    1.9  2  Pkinase       Protein kinase domain
    2.9e-34  118.5   0.5    1.5e-33  116.2   0.4    1.9  2  Pkinase_Tyr   Protein tyrosine kinase
    6.1e-18   63.9   4.2    0.00038   20.4   0.0    8.3  8  NHL           NHL repeat
    3.1e-12   46.7 123.5    8.3e-06   26.1   9.8    8.8  8  EGF_2         EGF-like domain
    0.00033   20.9  95.6      0.011   16.0   7.9    8.7  9  EGF           EGF-like domain
     0.0014   18.3   0.8     0.0042   16.7   0.1    2.3  3  SGL           SMP-30/Gluconolactonase/LRE-like region
     0.0033   16.8   0.0     0.0057   16.0   0.0    1.3  1  Kdo           Lipopolysaccharide kinase (Kdo/WaaP) family
     0.0055   17.3   8.6     0.0055   17.3   8.6   10.8 12  hEGF          Human growth factor-like EGF
     0.0096   15.9   3.6     0.0096   15.9   3.6    7.2  6  EGF_Tenascin  Tenascin EGF domain
  ------ inclusion threshold ------
        0.2   11.7   1.6       0.66   10.1   1.1    2.1  2  Insulin_TMD   Insulin receptor trans-membrane segment


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.55   9.9e+02     135     163 ..     256     288 ..     250     299 .. 0.77
   2 !  151.2   0.5   1.9e-47   3.5e-44       1     261 [.    1071    1343 ..    1071    1346 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.55
                 TEEEE-SGTTSEESSSSCS....BCTTTSCGGG CS
     Pkinase 135 gelKitDFGlakelesssk....ltsfvgtseY 163
                  +l i+D+Gla+ ++ +++     t++v +s +
  EFC38363.1 256 SNLLISDLGLARFIQFNKDqaqpNTNVVLSSSW 288
                 56889*******999877767766666666655 PP

  == domain 2  score: 151.2 bits;  conditional E-value: 1.9e-47
                  EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEE..EEEESSEEEEEEE--TTEBHHHHHHHHSS- CS
     Pkinase    1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlye..vfeekdelylvleyveggeladllerkgsl 95  
                  y+k +klG+G++G+V+   e +++++vAvK+i++ + + ++ k+v++  ++ ++   p+iv +++  ++e+  ++++++ + +++  + ++++k ++
  EFC38363.1 1071 YVKSKKLGSGASGTVFMFDELTNKEQVAVKIIEVLNPNGSEFKEVVNMFELSEEA-NPHIVPILGctMVENGGYICILMPLYKCDLRNWMYSNKETV 1166
                  7889*******************************99998887777766666665.57777776522678899************77777889999* PP

                  -HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE............EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHH CS
     Pkinase   96 seeeakkiakqilegleylHskgiiHrDlKpeNiLidekge............lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDv 180 
                  + e + +i+kqi+++l+ylHsk+++HrDlK++Ni+++++ +            l ++D+G ++  ++ss lt + gt +Y +PE + + e+s+k+Dv
  EFC38363.1 1167 PIEIIVEIVKQIASALQYLHSKNMVHRDLKQSNIFVSKSPDlsknnvnvssfqLCVGDWGSSRYQTRSS-LTAYEGTIQYSSPESIVKAEFSPKSDV 1262
                  *************************************84334444566777779999******999988.*************************** PP

                  HHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTS CS
     Pkinase  181 WslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqh 261 
                  WslG+ily+ll+        + k++  ++  +++ i ++ +  ++ +++ +++ + + dl+ ++l+ +p++R++ +e++q+
  EFC38363.1 1263 WSLGCILYQLLSADYNTCLMRVKQTSMNDQSDVQIIGNVEKFFSKRSDHSHKLYKIICDLMLEMLRFNPEERISTDEIVQK 1343
                  ***********99887777777777777777767777777777888888999999999********************985 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.26   4.6e+02     142     171 ..     258     288 ..     250     292 .. 0.78
   2 !  116.2   0.4   8.6e-37   1.5e-33       4     259 .]    1074    1344 ..    1071    1344 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.26
                  EEE-STTTHEET.TTSSEEEETTSSTSGGGG CS
  Pkinase_Tyr 142 vkisDfGLardi.ekddeyvkkeeaklpvkW 171
                    isD GLar i  ++d+ + +++  l+  W
   EFC38363.1 258 LLISDLGLARFIqFNKDQAQPNTNVVLSSSW 288
                  569*********5567777888887787777 PP

  == domain 2  score: 116.2 bits;  conditional E-value: 8.6e-37
                   EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS..-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr    4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl..khpnivkllgvct..keepllivteyvkgGdLlkfLrkk 95  
                   +kklG+Ga G+V++        +++++VavK+++  +   + +e+ e +++++     +p+iv +lg+ +  +++ ++i++ + k  dL++ + ++
   EFC38363.1 1074 SKKLGSGASGTVFMFDEL----TNKEQVAVKIIEVLN--PNGSEFKEVVNMFELSeeANPHIVPILGCTMveNGGYICILMPLYK-CDLRNWMYSN 1162
                   699**********98877....8999*******5433..334556555544433333789********99866666888888766.69*******9 PP

                   CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.....TTEEEE-STTTHEETTTSSEEEETTS...STSGGGGS-HHHHHHSEEE CS
  Pkinase_Tyr   96 ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.....nkvvkisDfGLardiekddeyvkkee...aklpvkWmapEslkekkft 183 
                    ke++ ++ +++++ q+A++++yL+sk++vHrdl   N+++s+     ++ v +s f L+     +++y+++++    +  +++ +pEs+ + +f+
   EFC38363.1 1163 -KETVPIEIIVEIVKQIASALQYLHSKNMVHRDLKQSNIFVSKspdlsKNNVNVSSFQLCVGDWGSSRYQTRSSltaYEGTIQYSSPESIVKAEFS 1257
                   .*****************************************999999999********9888777777555441115689*************** PP

                   HHHHHHHHHHHHHHHHTTSSGT.........TTTSHHHHHHHHHHT..TEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  184 sksDvWsfGvllwEiftlgesp.........ypglkneevleklke..gkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259 
                    ksDvWs G +l+ +++   ++         +++ ++ +++ ++++  +kr ++ +k  + + +lm + ++ +peeR +  e+v+kl
   EFC38363.1 1258 PKSDVWSLGCILYQLLSADYNTclmrvkqtsMNDQSDVQIIGNVEKffSKRSDHSHKLYKIICDLMLEMLRFNPEERISTDEIVQKL 1344
                   ****************9766667777775556666666677777654457778888888888899******************9987 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       2.5   4.5e+03       2      21 ..      95     115 ..      94     119 .. 0.81
   2 !   13.0   0.0   4.6e-05     0.082       1      22 [.     142     162 ..     142     167 .. 0.89
   3 !   12.1   0.0     9e-05      0.16      10      27 ..     426     443 ..     418     444 .. 0.83
   4 ?    1.4   0.1      0.22     4e+02      18      26 ..     495     503 ..     495     505 .. 0.89
   5 !    8.2   0.0    0.0015       2.7       2      25 ..     525     548 ..     525     551 .. 0.89
   6 !   20.4   0.0   2.1e-07   0.00038       1      24 [.     579     602 ..     579     605 .. 0.89
   7 ?    0.1   0.0      0.54   9.7e+02       3      16 ..     623     636 ..     621     636 .. 0.83
   8 ?   -2.6   0.1       3.9     7e+03       2      11 ..     839     848 ..     838     849 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.5
                 SSEEEEEEE.TTTEEEEEECC CS
         NHL   2 nyPhGvavd.snGdiyVaDse 21 
                 + P+   +d +++ +y+ Ds 
  EFC38363.1  95 YGPTNMYYDaTTDFLYILDSS 115
                 6788888999999******86 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 4.6e-05
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 f++P+G++++ n diyVaD++ 
  EFC38363.1 142 FSQPSGITMF-NKDIYVADTGK 162
                 89********.********986 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 9e-05
                 ETTTEEEEEECCCTEEEE CS
         NHL  10 dsnGdiyVaDsenhrvqv 27 
                 +++Gd++++D++n+r+++
  EFC38363.1 426 LDSGDLIISDTGNNRIRK 443
                 689*************97 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.22
                 EECCCTEEE CS
         NHL  18 aDsenhrvq 26 
                 aD++n+r++
  EFC38363.1 495 ADTNNNRIR 503
                 8*******8 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.0015
                 SSEEEEEEETTTEEEEEECCCTEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrv 25 
                 n P+G+ +++nGd+y+a  +nh +
  EFC38363.1 525 NGPNGIMYTPNGDLYIASQGNHKI 548
                 68***************9999977 PP

  == domain 6  score: 20.4 bits;  conditional E-value: 2.1e-07
                 BSSEEEEEEETTTEEEEEECCCTE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhr 24 
                 +nyP++v+v+s+G++y+aD +n  
  EFC38363.1 579 LNYPADVTVSSTGEVYIADWGNRA 602
                 79*****************99955 PP

  == domain 7  score: 0.1 bits;  conditional E-value: 0.54
                 SEEEEEEETTTEEE CS
         NHL   3 yPhGvavdsnGdiy 16 
                 + +Gv++++nGd++
  EFC38363.1 623 DLNGVTLTPNGDLL 636
                 568********985 PP

  == domain 8  score: -2.6 bits;  conditional E-value: 3.9
                 SSEEEEEEET CS
         NHL   2 nyPhGvavds 11 
                 ++PhG ++++
  EFC38363.1 839 CQPHGQCISN 848
                 9****88754 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   9.8   4.6e-09   8.3e-06       3      30 ..     656     680 ..     653     681 .. 0.89
   2 ?    1.6   2.6      0.21   3.8e+02      20      32 .]     704     716 ..     698     716 .. 0.77
   3 !   17.2   4.8   2.8e-06    0.0049       6      30 ..     730     753 ..     725     754 .. 0.83
   4 ?    0.8   5.7      0.38   6.7e+02      10      32 .]     767     788 ..     756     788 .. 0.72
   5 !   19.6   5.6   4.8e-07   0.00086       6      30 ..     802     825 ..     797     826 .. 0.84
   6 !    8.3  17.7    0.0016       2.9       6      32 .]     837     862 ..     833     862 .. 0.84
   7 !   12.0  13.8   0.00012      0.21       7      32 .]     875     899 ..     867     899 .. 0.87
   8 ?    4.4   8.0     0.028        51       8      32 .]     919     951 ..     914     951 .. 0.81

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 4.6e-09
       EGF_2   3 asdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 + +++C++hG+Cv  +G+C+Cdsg+ G+
  EFC38363.1 656 D-KNTCNNHGSCV--NGKCVCDSGWRGN 680
                 4.689********..**********996 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.21
       EGF_2  20 qCdCdsgyqGktC 32 
                 q +C++g++G +C
  EFC38363.1 704 QFSCQDGWTGLNC 716
                 558*******999 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 2.8e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 + C+ hG+C++ +  C C sg+ G+
  EFC38363.1 730 TVCSSHGKCISNN-TCNCVSGWRGN 753
                 68*******9555.9*******997 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.38
       EGF_2  10 ghGtCvnqcGqCdCdsgyqGktC 32 
                  +++C+ ++   +C++g+ G+ C
  EFC38363.1 767 HGEYCIGPN-TYKCQDGWIGDLC 788
                 367899777.569*********9 PP

  == domain 5  score: 19.6 bits;  conditional E-value: 4.8e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                   C+ hG+C++ +  C C+sg+ G+
  EFC38363.1 802 AVCNSHGQCISNN-TCNCFSGWRGN 825
                 46*******9555.9********97 PP

  == domain 6  score: 8.3 bits;  conditional E-value: 0.0016
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ hG+C++ +  C+C++gy G+ C
  EFC38363.1 837 NNCQPHGQCISNN-TCKCSTGYGGNGC 862
                 68*******9555.9***********9 PP

  == domain 7  score: 12.0 bits;  conditional E-value: 0.00012
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+++G+C n+  +C+C++ y+G +C
  EFC38363.1 875 GCSNNGYCSNTD-KCSCFPLYFGQQC 899
                 4*******8777.************* PP

  == domain 8  score: 4.4 bits;  conditional E-value: 0.028
       EGF_2   8 CgghGtCvnqcG........qCdCdsgyqGktC 32 
                 C+ +G C    +         C+C+ g+ G +C
  EFC38363.1 919 CSSNGNCTVIDNdqtrqnstICKCNEGFDGLYC 951
                 999****65566788776655***********9 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   7.9     6e-06     0.011       3      31 ..     657     680 ..     654     681 .. 0.91
   2 ?   -1.2   0.0       1.5   2.6e+03      24      31 ..     707     714 ..     706     715 .. 0.86
   3 !   10.1   6.9   0.00045      0.81       5      31 ..     728     753 ..     721     754 .. 0.86
   4 ?   -2.1   0.4       2.8     5e+03      19      25 ..     776     780 ..     767     786 .. 0.60
   5 !   10.5   5.2   0.00033       0.6       4      31 ..     800     825 ..     797     826 .. 0.91
   6 ?    3.6  13.6     0.049        87       1      31 [.     833     860 ..     833     861 .. 0.91
   7 !    8.5   5.0    0.0014       2.6       5      30 ..     875     896 ..     870     898 .. 0.86
   8 !   12.7   3.4   6.9e-05      0.12       4      31 ..     916     949 ..     913     950 .. 0.82
   9 ?   -0.6   0.2      0.99   1.8e+03      10      23 ..    1134    1146 ..    1133    1146 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 6e-06
                 STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 +n+C+n+G Cv+++     C C++G+ G+
  EFC38363.1 657 KNTCNNHGSCVNGK-----CVCDSGWRGN 680
                 588***********.....********97 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.5
                 ECTTEEST CS
         EGF  24 CpeGytGk 31 
                 C+ G+tG 
  EFC38363.1 707 CQDGWTGL 714
                 ******96 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.00045
                 T...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p...CsngGtCvdtgrggytCiCpeGytGk 31 
                 +   Cs +G+C+++     tC C +G+ G+
  EFC38363.1 728 TttvCSSHGKCISNN----TCNCVSGWRGN 753
                 3458*******9999....*********97 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 2.8
                 EEEEEEC CS
         EGF  19 gytCiCp 25 
                 +y+C  +
  EFC38363.1 776 TYKC--Q 780
                 5555..4 PP

  == domain 5  score: 10.5 bits;  conditional E-value: 0.00033
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 np  C+ +G C+++     tC C +G+ G+
  EFC38363.1 800 NPavCNSHGQCISNN----TCNCFSGWRGN 825
                 7799*******9999....*********97 PP

  == domain 6  score: 3.6 bits;  conditional E-value: 0.049
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  n+C+ +G C+++     tC+C++Gy G+
  EFC38363.1 833 CDGvNNCQPHGQCISNN----TCKCSTGYGGN 860
                 777799*******9999....********997 PP

  == domain 7  score: 8.5 bits;  conditional E-value: 0.0014
                 TSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 pCsngGtCvdtgrggytCiCpeGytG 30 
                  Csn+G C    +++ +C C + y+G
  EFC38363.1 875 GCSNNGYC----SNTDKCSCFPLYFG 896
                 5*******....5777******9999 PP

  == domain 8  score: 12.7 bits;  conditional E-value: 6.9e-05
                 TT.STTT-EE..EEET...TTEEEEEECTTEEST CS
         EGF   4 np.CsngGtC..vdtg...rggytCiCpeGytGk 31 
                 ++ Cs +G C  +d+     ++ +C+C eG++G 
  EFC38363.1 916 TKgCSSNGNCtvIDNDqtrQNSTICKCNEGFDGL 949
                 456*******9955556778************96 PP

  == domain 9  score: -0.6 bits;  conditional E-value: 0.99
                  -EEEEETTTEEEEE CS
         EGF   10 GtCvdtgrggytCi 23  
                  G C  +++ggy+Ci
  EFC38363.1 1134 G-CTMVENGGYICI 1146
                  4.9888999****6 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       4.4   7.9e+03     145     163 ..     152     170 ..     147     176 .. 0.82
   2 ?   -3.0   0.0       2.5   4.4e+03     130     163 ..     414     446 ..     385     456 .. 0.69
   3 !   16.7   0.1   2.4e-06    0.0042     130     220 ..     521     616 ..     486     639 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 4.4
         SGL 145 gktlYlaDsltrkiwaydv 163
                 +k +Y+aD+ +  +w++++
  EFC38363.1 152 NKDIYVADTGKAVVWKVQI 170
                 5778999999999999876 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.5
         SGL 130 lddltipNGlawspdgktlYlaDsltrkiwaydv 163
                 +  +t pN++ ++ d+  l++ D+ +++i ++d 
  EFC38363.1 414 IALMTRPNTV-LQLDSGDLIISDTGNNRIRKIDS 446
                 5555566654.56666667777777777777664 PP

  == domain 3  score: 16.7 bits;  conditional E-value: 2.4e-06
         SGL 130 lddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklieei 220
                  d+++ pNG++ +p g+ lY+a   ++ki++y+ ++ ++  +n    + ++ g+      ++p  ++v ++G+v++A wg+  v+++  +G++i+ i
  EFC38363.1 521 NDGINGPNGIMYTPNGD-LYIASQGNHKIMKYSNSQLSTVAGNGYAGYSGDGGParnaklNYPADVTVSSTGEVYIADWGNRAVRKVFRNGTIITLI 616
                 58999*********997.78899999********9999988999888999999999999988999**************************999866 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   3.2e-06    0.0057     103     154 ..    1153    1205 ..    1104    1221 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 3.2e-06
         Kdo  103 qdLedllakwae.laeelkrallkavgrliaklhragvnHadlyaknillqqe 154 
                   dL +++ + +e ++ e   +++k+++ + + lh+ ++ H+dl   ni++ + 
  EFC38363.1 1153 CDLRNWMYSNKEtVPIEIIVEIVKQIASALQYLHSKNMVHRDLKQSNIFVSKS 1205
                  58888888877779999999*****************************9876 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   1.2       9.6   1.7e+04       3      16 ..     190     202 ..     189     203 .. 0.60
   2 ?   -4.1   0.0        10   1.8e+04       5       9 ..     652     656 ..     651     658 .. 0.76
   3 !   17.3   8.6   3.1e-06    0.0055       1      22 []     660     677 ..     660     677 .. 0.97
   4 ?   -0.8   0.7       1.5   2.7e+03       6      11 ..     706     711 ..     695     717 .. 0.56
   5 !    8.0   6.2    0.0027       4.8       1      22 []     732     750 ..     732     750 .. 0.89
   6 ?    3.6   0.5     0.062   1.1e+02       3      17 ..     767     780 ..     765     780 .. 0.82
   7 ?    1.0   8.9      0.43   7.8e+02       1      22 []     804     822 ..     804     822 .. 0.84
   8 ?   -4.1   0.7        10   1.8e+04       4      17 ..     825     834 ..     824     834 .. 0.68
   9 !    7.9   7.2    0.0029       5.2       1      22 []     839     857 ..     839     857 .. 0.90
  10 ?    0.8   8.7       0.5     9e+02       1      18 [.     876     890 ..     876     890 .. 0.94
  11 ?    3.8   2.3     0.057     1e+02       2      22 .]     920     946 ..     919     946 .. 0.66
  12 ?    0.6   0.4      0.58     1e+03       3      16 ..    1140    1153 ..    1135    1154 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 9.6
                 TT-EES..-SS.-E CS
        hEGF   3 ngGtCidgvggykC 16 
                 n+  C++ +   +C
  EFC38363.1 190 NNNYCDNVYAT-TC 202
                 55599955444.76 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 10
                 -EES. CS
        hEGF   5 GtCid 9  
                 G+Cid
  EFC38363.1 652 GSCID 656
                 79996 PP

  == domain 3  score: 17.3 bits;  conditional E-value: 3.1e-06
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cnn+G+C+   +g kC+C++G+
  EFC38363.1 660 CNNHGSCV---NG-KCVCDSGW 677
                 ********...88.******** PP

  == domain 4  score: -0.8 bits;  conditional E-value: 1.5
                 EES..- CS
        hEGF   6 tCidgv 11 
                 +C+dg 
  EFC38363.1 706 SCQDGW 711
                 355555 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0027
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+ +G Ci    +++C C +G+
  EFC38363.1 732 CSSHGKCI---SNNTCNCVSGW 750
                 9999****...446******** PP

  == domain 6  score: 3.6 bits;  conditional E-value: 0.062
                 TT-EES..-SS.-EE CS
        hEGF   3 ngGtCidgvggykCi 17 
                 +g  Ci g++ ykC+
  EFC38363.1 767 HGEYCI-GPNTYKCQ 780
                 4448**.99*****7 PP

  == domain 7  score: 1.0 bits;  conditional E-value: 0.43
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn +G+Ci    +++C C +G+
  EFC38363.1 804 CNSHGQCI---SNNTCNCFSGW 822
                 9*******...446****7777 PP

  == domain 8  score: -4.1 bits;  conditional E-value: 10
                 T-EES..-SS.-EE CS
        hEGF   4 gGtCidgvggykCi 17 
                 + +C+     ++C+
  EFC38363.1 825 NSICT----QFTCD 834
                 44898....78885 PP

  == domain 9  score: 7.9 bits;  conditional E-value: 0.0029
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G+Ci    +++C C  Gy
  EFC38363.1 839 CQPHGQCI---SNNTCKCSTGY 857
                 ********...446*****999 PP

  == domain 10  score: 0.8 bits;  conditional E-value: 0.5
                 --TT-EES..-SS.-EE- CS
        hEGF   1 CnngGtCidgvggykCiC 18 
                 C+n+G C    +  kC C
  EFC38363.1 876 CSNNGYCS---NTDKCSC 890
                 ********...778***9 PP

  == domain 11  score: 3.8 bits;  conditional E-value: 0.057
                 -TT-EES..-SS.......-EE--TTX CS
        hEGF   2 nngGtCidgvgg......ykCiCpPGy 22 
                 + +G C+   +       + C C+ G+
  EFC38363.1 920 SSNGNCTVIDNDqtrqnsTICKCNEGF 946
                 555566644444666666********9 PP

  == domain 12  score: 0.6 bits;  conditional E-value: 0.58
                  TT-.EES..-SS.-E CS
        hEGF    3 ngG.tCidgvggykC 16  
                  ngG +Ci +   ykC
  EFC38363.1 1140 NGGyICI-LMPLYKC 1153
                  7777888.6666777 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   3.6   5.4e-06    0.0096       6      25 ..     660     679 ..     658     683 .. 0.90
   2 ?    0.4   7.3       0.4   7.2e+02       6      29 .]     732     757 ..     730     757 .. 0.86
   3 ?   -0.1   2.3      0.59   1.1e+03       5      25 ..     803     824 ..     800     828 .. 0.70
   4 ?   -1.2   3.7       1.2   2.2e+03       6      28 ..     839     862 ..     837     863 .. 0.76
   5 ?    0.8   3.8      0.31   5.5e+02       5      28 ..     875     899 ..     873     900 .. 0.87
   6 ?    1.9   0.2      0.14   2.5e+02       5      12 ..     918     925 ..     916     930 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 5.4e-06
  EGF_Tenascin   6 CssRGvCvDGqCiCDsEYsG 25 
                   C   G Cv+G+C+CDs + G
    EFC38363.1 660 CNNHGSCVNGKCVCDSGWRG 679
                   9999************9887 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.4
  EGF_Tenascin   6 CssRGvCvD.GqCiCDsEYsGD.DCs 29 
                   Css G C+    C C s + G+ DCs
    EFC38363.1 732 CSSHGKCISnNTCNCVSGWRGNsDCS 757
                   *******96267*******9966998 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.59
  EGF_Tenascin   5 GCssRGvCvD.GqCiCDsEYsG 25 
                    C s G C+    C C s + G
    EFC38363.1 803 VCNSHGQCISnNTCNCFSGWRG 824
                   5889998885146888777666 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 1.2
  EGF_Tenascin   6 CssRGvCvD.GqCiCDsEYsGDDC 28 
                   C   G C+    C C   Y G+ C
    EFC38363.1 839 CQPHGQCISnNTCKCSTGYGGNGC 862
                   666777875156999999*99999 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.31
  EGF_Tenascin   5 GCssRGvCvDG.qCiCDsEYsGDDC 28 
                   GCs  G C +  +C C   Y G  C
    EFC38363.1 875 GCSNNGYCSNTdKCSCFPLYFGQQC 899
                   9*******97537***999999999 PP

  == domain 6  score: 1.9 bits;  conditional E-value: 0.14
  EGF_Tenascin   5 GCssRGvC 12 
                   GCss G C
    EFC38363.1 918 GCSSNGNC 925
                   9*****99 PP

>> Insulin_TMD  Insulin receptor trans-membrane segment
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       7.2   1.3e+04      27      44 ..     259     276 ..     258     277 .. 0.84
   2 ?   10.1   1.1   0.00037      0.66      14      42 ..     963     992 ..     955     994 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 7.2
  Insulin_TMD  27 llllvigavfvvvkKrQt 44 
                  l++ ++ a f+ + K Q 
   EFC38363.1 259 LISDLGLARFIQFNKDQA 276
                  777889999******996 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00037
  Insulin_TMD  14 ivkIvigPvici.illllvigavfvvvkKr 42 
                  ++++vi+ + +i  l+++++++ fv  kKr
   EFC38363.1 963 VAAVVIVVLLFIcCLIAFIAVGGFVYYKKR 992
                  6778888777652699*************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1139  (0.0635284); expected 358.6 (0.02)
Passed bias filter:                      636  (0.0354733); expected 358.6 (0.02)
Passed Vit filter:                        86  (0.0047967); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.02u 0.34s 00:00:01.36 Elapsed: 00:00:00.51
# Mc/sec: 7964.74
//
Query:       EFC38364.1  [L=327]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.9e-11   41.6   0.1      0.014   15.4   0.0    4.5  5  NHL           NHL repeat
    2.3e-05   24.5   0.1       0.98    9.7   0.0    4.1  4  Arylesterase  Arylesterase
  ------ inclusion threshold ------
       0.12   11.6   0.0        5.9    6.0   0.0    2.5  3  Lactonase     Lactonase, 7-bladed beta-propeller
       0.29   10.3   9.2      0.089   11.9   0.3    3.0  3  DUF5128       6-bladed beta-propeller


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.0   0.00013      0.57      15      28 .]      51      64 ..      36      64 .. 0.84
   2 ?   -2.5   0.0       1.5   6.8e+03      11      21 ..     100     110 ..      97     111 .. 0.76
   3 ?   -0.3   0.0       0.3   1.4e+03      15      21 ..     166     172 ..     165     177 .. 0.74
   4 !   15.4   0.0   3.1e-06     0.014       1      25 [.     247     272 ..     247     273 .. 0.95
   5 !    9.8   0.0   0.00019      0.85       3      21 ..     300     319 ..     298     326 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00013
                EEEEECCCTEEEEE CS
         NHL 15 iyVaDsenhrvqvF 28
                ++++Ds+n rvq++
  EFC38364.1 51 LLICDSGNKRVQIY 64
                79**********98 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.5
                 TTTEEEEEECC CS
         NHL  11 snGdiyVaDse 21 
                 ++  +y+++s+
  EFC38364.1 100 NSLLLYITCSN 110
                 66789999986 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.3
                 EEEEECC CS
         NHL  15 iyVaDse 21 
                 +yV+Ds 
  EFC38364.1 166 LYVCDST 172
                 7****75 PP

  == domain 4  score: 15.4 bits;  conditional E-value: 3.1e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrv 25 
                 f+yP+G+ +  +++++yV+D  n+r+
  EFC38364.1 247 FSYPRGIFLEeKMNRLYVCDASNNRI 272
                 89**********************98 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.00019
                 SEEEEEEE.TTTEEEEEECC CS
         NHL   3 yPhGvavd.snGdiyVaDse 21 
                  P++v++d s+G ++V+D++
  EFC38364.1 300 TPTSVVIDdSTGTLLVSDNK 319
                 69****************96 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.58   2.6e+03      67      81 ..     165     179 ..     158     182 .. 0.81
   2 !    9.7   0.0   0.00022      0.98      51      81 ..     196     226 ..     191     232 .. 0.85
   3 !    5.9   0.0    0.0033        15      48      79 ..     242     273 ..     228     280 .. 0.84
   4 ?    3.8   0.0     0.014        64      38      81 ..     283     326 ..     274     327 .] 0.88

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.58
  Arylesterase  67 yiyvadilresihvm 81 
                   ++yv d++++ i ++
    EFC38364.1 165 VLYVCDSTKRRIVML 179
                   79*****99999765 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00022
  Arylesterase  51 sglssanGInidadkkyiyvadilresihvm 81 
                   +++ssa  I id++kk i v+++  + + ++
    EFC38364.1 196 EKFSSAVSILIDSKKKWILVSEMAGQRVKIL 226
                   789********************88776554 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0033
  Arylesterase  48 vvasglssanGInidadkkyiyvadilresih 79 
                   +  + +s + GI ++ +   +yv d  ++ i 
    EFC38364.1 242 KELDEFSYPRGIFLEEKMNRLYVCDASNNRIS 273
                   56789********************9999885 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.014
  Arylesterase  38 vvYyspsevkvvasglssanGInidadkkyiyvadilresihvm 81 
                   v Y+ +++ +    +l++++ ++id     + v+d   ++++++
    EFC38364.1 283 VEYFGGKNSNMEQVQLKTPTSVVIDDSTGTLLVSDNKLDQVFIF 326
                   66999999999999**************9999999988888875 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0      0.87   3.9e+03     293     319 ..      39      65 ..      17      66 .. 0.70
   2 ?    6.0   0.0    0.0013       5.9     245     322 ..     200     279 ..     164     305 .. 0.74
   3 ?    2.8   0.0     0.013        57     134     171 ..     290     327 .]     279     327 .] 0.74

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.87
                 --EEEE-TTSSEEEEEETTTTEEEEEE CS
   Lactonase 293 PRdfaldpsgklllvanqksdnvtvfe 319
                 P  +++++  ++ll+++   ++v+++ 
  EFC38364.1  39 PMGLKISKLMNWLLICDSGNKRVQIYD 65 
                 556667777777777777777777776 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0013
                 -EEEEEE-TTSSEEEEEETSSTEEEEEEE..-TTT--EEEEEEEE-SSS.--EEEE-TTSSEEEEEETTTTEEEEEEEET CS
   Lactonase 245 saaeIrlspdgkflyvSnRgadsiavfav..deadgtltlveevstegkfPRdfaldpsgklllvanqksdnvtvferda 322
                 sa  I + ++ k++ vS+     + +++    +   +l + ++   e  +PR + l+++ + l+v++ + ++++++  d+
  EFC38364.1 200 SAVSILIDSKKKWILVSEMAGQRVKILDYktRQLLHSLGKYGKELDEFSYPRGIFLEEKMNRLYVCDASNNRISLIDLDK 279
                 55567788888888888888555555554003333444444455555567999999999999999999999999988875 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.013
                 .SSTTT-SSTTEEEEEE-TTSSEEEEEETTTTEEEEEE CS
   Lactonase 134 gpnperqesphaHsvvldpdgkfllvpDLGtDrvrvyk 171
                  +n e+ + + + svv+d +   llv D  +D+v++++
  EFC38364.1 290 NSNMEQVQLKTPTSVVIDDSTGTLLVSDNKLDQVFIFR 327
                 55566666666778888888888999999999998885 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   1.4     0.018        83      94     176 ..      30     125 ..      18     167 .. 0.71
   2 ?   11.9   0.3     2e-05     0.089      59     135 ..     207     284 ..     152     298 .. 0.84
   3 ?   -0.2   0.1     0.098   4.4e+02      58      78 ..     306     326 ..     291     327 .] 0.71

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.018
     DUF5128  94 GPgEYlq..indfiidksnesIyildfmknkiltYdLegykfieekkldllvsdv..........aqlekdkli.fdssriedekrskfnlvvtde 176
                 G  EYl        i k  + + i d+ ++++ +Yd   +++++ +++  ++  v          +  +++ l+ + +++ +   ++k ++v +++
  EFC38364.1  30 GSSEYLLndPMGLKISKLMNWLLICDSGNKRVQIYDRFNFEYLYSIRMKTQPQYVeieewhdqcgYYADENSLLlYITCSNQVLIKMKVTVVMEEN 125
                 6666664224456678888999999**9999*****99*******999999943333666666566667777766765555533334444444443 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 2e-05
     DUF5128  59 kvvdkrifvlDsaknnlfvFd.kkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknkiltYdLegykfie 135
                    +k i+v ++a +++ + d k+ +  +  g+ G+  +E+ +   ++++++ +++y+ d+ +n+i   dL+ ++f+e
  EFC38364.1 207 DSKKKWILVSEMAGQRVKILDyKTRQLLHSLGKYGKELDEFSYPRGIFLEEKMNRLYVCDASNNRISLIDLDKLEFVE 284
                 334455666666667799999999999999*******************************************99986 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.098
     DUF5128  58 ikvvdkrifvlDsaknnlfvF 78 
                 i ++ + ++v D+   ++f+F
  EFC38364.1 306 IDDSTGTLLVSDNKLDQVFIF 326
                 334558999*99999*****9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (327 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       760  (0.0423894); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 2203.00
//
Query:       EFC38365.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1222  (0.0681577); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.23s 00:00:00.75 Elapsed: 00:00:00.42
# Mc/sec: 1852.44
//
Query:       EFC38366.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.1   0.0       0.28   11.0   0.0    1.6  1  RVP_2     Retroviral aspartyl protease


Domain annotation for each model (and alignments):
>> RVP_2  Retroviral aspartyl protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   1.6e-05      0.28      78     129 ..     164     215 ..     160     222 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.6e-05
       RVP_2  78 keicksveieiqgiefladlilLdlkdlDviLgmdWLsknkanidcaekkvt 129
                 + + k++++ i++++f  d  lL  + +D i+ md  ++   + d a kk++
  EFC38366.1 164 HLVGKKLTVCIASWSFFWDWNLLSESRVDKIITMDTYAARAEQFDSAFKKAV 215
                 5678999*****************************9999999998766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.24s 00:00:00.70 Elapsed: 00:00:00.41
# Mc/sec: 2028.23
//
Query:       EFC38367.1  [L=170]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       345  (0.0192426); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.24s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 1212.85
//
Query:       EFC38368.1  [L=1950]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.2e-54  182.0   0.0    1.7e-53  181.0   0.0    1.6  1  Guanylate_cyc    Adenylate and Guanylate cyclase catalytic do
    2.1e-12   47.2   0.4    8.4e-12   45.3   0.4    2.2  1  PAS_9            PAS domain
    5.7e-09   36.0   0.0    1.5e-08   34.7   0.0    1.7  1  PAS              PAS fold
    1.4e-05   25.7   0.0    5.4e-05   23.8   0.0    2.0  1  Methyltransf_25  Methyltransferase domain
     0.0001   22.1   0.0    0.00026   20.8   0.0    1.6  1  Methyltransf_31  Methyltransferase domain
    0.00015   22.5   0.0    0.00062   20.5   0.0    2.1  1  Methyltransf_12  Methyltransferase domain
    0.00035   20.1   0.4     0.0012   18.4   0.0    2.1  2  Methyltransf_4   Putative methyltransferase
    0.00052   19.9   0.0     0.0011   18.8   0.0    1.5  1  Methyltransf_23  Methyltransferase domain
      0.002   17.7   0.0     0.0046   16.5   0.0    1.6  1  MTS              Methyltransferase small domain
     0.0058   16.9   0.1      0.041   14.2   0.1    2.5  1  Sec3_C_2         Sec3 exocyst complex subunit
  ------ inclusion threshold ------
      0.021   15.5   0.0       0.18   12.5   0.0    2.4  2  Methyltransf_11  Methyltransferase domain
       0.38   10.1   2.1       0.68    9.3   0.2    2.2  2  HNOBA            Heme NO binding associated


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.0   0.0   1.1e-56   1.7e-53       3     182 ..    1728    1909 ..    1726    1910 .. 0.97

  Alignments for each domain:
  == domain 1  score: 181.0 bits;  conditional E-value: 1.1e-56
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevave 95  
                     ae++++v+++F+d+vgftalss ++p +++ lLn++++ fd+l+d+++++k+ktiGday +v glp +++ +h ++ +++a+d ++ ++ +++ 
     EFC38368.1 1728 AERFNDVSVFFSDMVGFTALSSDMNPSDLILLLNNVVNGFDDLTDKYELEKIKTIGDAYFCVGGLPiNPQSDHPERTLRFAMDCFSVIRGFNQA 1821
                     799***************************************************************999*******************999888 PP

  Guanylate_cyc   96 s..keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182 
                     +  ++ +++r+Gi+tG+vvagviG+kk+ yd+wG+t+n+Asrmes++k+g+iq+s++tye   + +fe++er +++vkGkg  ++y+++
     EFC38368.1 1822 TngEKVINIRIGINTGSVVAGVIGKKKFAYDLWGDTINTASRMESNSKPGRIQISRSTYERVYDLGFEFEER-SIDVKGKGVCTCYLMN 1909
                     877899****************************************************************98.69***********986 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.3   0.4   5.6e-15   8.4e-12       2     104 .]    1581    1689 ..    1580    1689 .. 0.90

  Alignments for each domain:
  == domain 1  score: 45.3 bits;  conditional E-value: 5.6e-15
       PAS_9    2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk.........kerevevvlirkngetfwvlltaspvkddd 89  
                  dg ++ n++g+il +N+a  rl+   p ev+g ++  lf  d+ ++++l ++ ++ r+         + +  e+ +irkn +tf+++++++  +d+d
  EFC38368.1 1581 DGAVLSNEKGEILLFNTACQRLFSKIPSEVMGLKFYSLF--DKANESKLIDIARNCRDylvegennkNGEVMELNCIRKNLSTFPAQVNIFVTRDGD 1675
                  6888999***************9666*************..888888888888888888888888*999**************************99 PP

       PAS_9   90 gelvgiivilrDite 104 
                  +++v i+++++Dit+
  EFC38368.1 1676 NKVV-IVCFIKDITT 1689
                  9988.79******95 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.7   0.0   9.7e-12   1.5e-08       4     113 .]    1573    1687 ..    1571    1687 .. 0.93

  Alignments for each domain:
  == domain 1  score: 34.7 bits;  conditional E-value: 9.7e-12
                  HHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHH...HHHHHHHHHHHHTT-ECCCCEEEEC...TTSSEEEEEEEEE CS
         PAS    4 raileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheedda...elaelleqlleqgeesrageisfkl...rdgrpihlevras 94  
                   ++l+s+ d+ ++ +e+g+il++N+a ++l+   ++ev+g +++ l+    ++   + a+  + +l +ge++++ge+ +     ++ ++++++v+  
  EFC38368.1 1573 NNLLHSMVDGAVLSNEKGEILLFNTACQRLFSKIPSEVMGLKFYSLFDKANESkliDIARNCRDYLVEGENNKNGEVMELNcirKNLSTFPAQVNIF 1669
                  579*****************************************99998888899999999999999999999999977768888************ PP

                  EEEETTEEEEEEEEEEEES CS
         PAS   95 pvrdaggeilgflgvlrdi 113 
                   +rd++ ++  ++++++di
  EFC38368.1 1670 VTRDGDNKV-VIVCFIKDI 1687
                  *****9999.********8 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.0   3.6e-08   5.4e-05       2      69 ..     176     257 ..     176     281 .. 0.76

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 3.6e-08
                      EEET-TTSHHHHHHHCTST.SSEEEEEESSHHHHHHHHHHHHH.TTT...TEEEEESBCCG.........BSSSTTTEEEEE CS
  Methyltransf_25   2 LdlGcGtGrltlalakrlg.kakvtgvDiseemleaareraee.egl...nvefvqgdaed.........lpfedgsfDlvv 69 
                      Ld+GcG+G +++++a++++   k +gv+  +e++  ar+ ++   gl   ++++++ d+++         lp+ +g fDlv+
       EFC38368.1 176 LDIGCGNGSVLMMVARNMPlTTKCIGVEARSEAVSLARRSIAFnCGLdstRIQVRNRDFREinsntmmnvLPEGSGFFDLVT 257
                      8****************9779******************9976423366799999999977222222223345666777776 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   1.8e-07   0.00026       6      69 ..     174     240 ..     172     268 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 1.8e-07
  Methyltransf_31   6 rvlDlGCGtGeltfelaeelgpkaevvGiDiseeaielAre.naqklgld..nveFeqgdieelekl 69 
                      ++lD+GCG+G  +   a+++    + +G++   ea++lAr  +a + gld  +++++  d+ e++++
       EFC38368.1 174 NYLDIGCGNGSVLMMVARNMPLTTKCIGVEARSEAVSLARRsIAFNCGLDstRIQVRNRDFREINSN 240
                      78***************988889****************9977777777766888888888887754 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   4.1e-07   0.00062       1      69 [.     176     255 ..     176     259 .. 0.83

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 4.1e-07
  Methyltransf_12   1 LeiGcGtGsllrallekl.pdieytgvDispsaiedakeklakrennnnnnvelealdlldldgg..........ssfDl 69 
                      L+iGcG+Gs+l++++++   +++ +gv+  ++a+  a++ +a++++++ ++++++++d  +  ++          + fDl
       EFC38368.1 176 LDIGCGNGSVLMMVARNMpLTTKCIGVEARSEAVSLARRSIAFNCGLDSTRIQVRNRDFREINSNtmmnvlpegsGFFDL 255
                      8*****************8888888******************************9997655444555555555555555 PP

>> Methyltransf_4  Putative methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   7.9e-07    0.0012       5      68 ..     175     246 ..     173     251 .. 0.77
   2 ?   -4.1   0.1       6.4   9.5e+03      74      87 ..     558     571 ..     556     572 .. 0.86

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 7.9e-07
                     EEEET-TTSHHHHHHHHHST.TSEEEEEES-HHHHHHHHHHHHHC........TTSSEEEEES-CCCHHHHCS CS
  Methyltransf_4   5 vleiGcGkGeflvalAkknP.dknflGiEirvkvvakvlkkieal........elkNlrilrgdalkvllell 68 
                      l+iGcG+G++l+  A + P +++++G+E r++ v  + ++i+ +        +++N    + +  +++ ++l
      EFC38368.1 175 YLDIGCGNGSVLMMVARNMPlTTKCIGVEARSEAVSLARRSIAFNcgldstriQVRNRDFREINS-NTMMNVL 246
                     68******************6678***********999888887777766666666655555554.4444555 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 6.4
                     EEEEEES-----SG CS
  Methyltransf_4  74 ekifilFPDPwfKk 87 
                     + ++++F  P+fK+
      EFC38368.1 558 SIVYLFFGVPFFKR 571
                     5699********96 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   7.5e-07    0.0011      24      87 ..     173     257 ..     127     265 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 7.5e-07
  Methyltransf_23  24 grvLdiGcGtGillevlrengf...svtgvDlspeaveiae...........kakkaqkdqfdeq.......eaaepqgkfdlIv 87 
                      +++LdiGcG G++l   ++n     +++gv++++eav++a+           ++++ ++  f+e+         +e +g fdl++
       EFC38368.1 173 SNYLDIGCGNGSVLMMVARNMPlttKCIGVEARSEAVSLARrsiafncgldsTRIQVRNRDFREInsntmmnVLPEGSGFFDLVT 257
                      49*********999999888544679**************999999999998555555555544433333334555777788776 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   3.1e-06    0.0046      33      89 ..     173     234 ..     165     282 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3.1e-06
                 SEEEEET-TTSHHHHHHHHHTTC.E.EEEEESBHHHHHHHHHHHHHTTGC....EEEEE-ST CS
         MTS  33 gkvlDlGcGaGvlgaalakespeae.vtlvdvdarAlesakenleankle....vevvasdv 89 
                  + lD+GcG+G + +++a++ p ++    v++  +A+ +a++ ++ n       ++v+++d 
  EFC38368.1 173 SNYLDIGCGNGSVLMMVARNMPLTTkCIGVEARSEAVSLARRSIAFNCGLdstrIQVRNRDF 234
                 468*******************87769999************99988533255566665555 PP

>> Sec3_C_2  Sec3 exocyst complex subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.1   2.7e-05     0.041      40      73 ..    1206    1239 ..    1200    1244 .. 0.93

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.7e-05
    Sec3_C_2   40 ekielkevkdilqdsilGCeslfstlnlyslels 73  
                  eki+++e +dil    lGC   fst+ l s+++s
  EFC38368.1 1206 EKIHIQESRDILGQILLGCSVGFSTIILISISIS 1239
                  89******************************99 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   0.00012      0.18       1      41 [.     176     219 ..     176     259 .. 0.72
   2 ?   -0.4   0.0       1.2   1.8e+03       3      64 ..    1832    1897 ..    1830    1911 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00012
                      EEET-TTSHHHHHHHHTT...SEEEEEES-HHHHHHHHHHCCHH CS
  Methyltransf_11   1 LdvGcGtGrlaealakrg...arvvgvDlskemlklakekasee 41 
                      Ld+GcG+G+++  +a++    ++++gv+   e++ la++ +  +
       EFC38368.1 176 LDIGCGNGSVLMMVARNMpltTKCIGVEARSEAVSLARRSIAFN 219
                      8**************888999*************9998776543 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1.2
                       ET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-.EEEETTEECCC.....TSS-TT-EEE CS
  Methyltransf_11    3 vGcGtGrlaealakrgarvvgvDlskemlklakekaseegl.kvefvvadaek.....lpfednsfDl 64  
                       +G  tG++++ +   g++ ++ Dl+  ++++a++  s++++ ++++ +++ e+     + fe+ s+D+
       EFC38368.1 1832 IGINTGSVVAGVI--GKKKFAYDLWGDTINTASRMESNSKPgRIQISRSTYERvydlgFEFEERSIDV 1897
                       7888888888888..899999********999877777777777776666664333224588888886 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.56   8.3e+02     175     202 ..     789     816 ..     762     822 .. 0.75
   2 ?    9.3   0.2   0.00045      0.68     193     220 ..    1692    1719 ..    1686    1720 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.56
       HNOBA 175 aelelaldqleeksaeLeesmkeleeek 202
                  e++  ld+le+k++eL++ ++   +e+
  EFC38368.1 789 LEVKALLDKLEQKQEELKNVHRAFWKEM 816
                 4778889999999999999988766665 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00045
       HNOBA  193 esmkeleeekkrtdeLLysmiPkevAer 220 
                  +++  l eekk +++LL +++P++vA +
  EFC38368.1 1692 KANTLLSEEKKNSEKLLRNILPESVALK 1719
                  677889********************76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1950 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1156  (0.0644765); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 1.13u 0.29s 00:00:01.42 Elapsed: 00:00:00.49
# Mc/sec: 12060.97
//
Query:       EFC38369.1  [L=520]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.1e-22   77.0   2.6      9e-06   25.5   0.1    6.5  6  NHL             NHL repeat
    6.5e-10   39.2  52.7    5.4e-05   23.5   4.0    4.5  4  EGF_2           EGF-like domain
    7.8e-05   22.9  34.2       0.27   11.6   2.2    4.2  3  EGF             EGF-like domain
    0.00044   19.9   0.7       0.13   11.8   0.0    3.8  4  SGL             SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
       0.15   11.3   0.7        4.7    6.4   0.0    2.7  3  SdiA-regulated  SdiA-regulated


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.1    0.0025       9.1       5      17 ..      54      66 ..      54      67 .. 0.92
   2 !   15.2   0.0   4.6e-06     0.017       1      26 [.     107     132 ..     107     134 .. 0.91
   3 !   18.0   0.1     6e-07    0.0021       1      27 [.     164     191 ..     164     192 .. 0.95
   4 ?   -1.1   0.0      0.67   2.4e+03       7      17 ..     227     237 ..     227     237 .. 0.84
   5 !    5.1   0.0    0.0073        26       2      23 ..     279     300 ..     279     304 .. 0.91
   6 !   25.5   0.1   2.5e-09     9e-06       3      27 ..     336     360 ..     335     361 .. 0.94

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0025
                EEEEEETTTEEEE CS
         NHL  5 hGvavdsnGdiyV 17
                +Gvav+s G+++V
  EFC38369.1 54 EGVAVNSKGEVLV 66
                59**********9 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 4.6e-06
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 + yP+G++v++ ++iy  ++++h v+
  EFC38369.1 107 LGYPAGITVNDKDEIYLVEYGTHMVR 132
                 679********************776 PP

  == domain 3  score: 18.0 bits;  conditional E-value: 6e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 fn+P Gv+v+  +Gd+y++D+ n+r+++
  EFC38369.1 164 FNHPYGVSVNpLTGDVYISDFSNNRIRK 191
                 89********99**************86 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 0.67
                 EEEETTTEEEE CS
         NHL   7 vavdsnGdiyV 17 
                 +a  +nGd+y+
  EFC38369.1 227 IATGPNGDLYI 237
                 67789****97 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.0073
                 SSEEEEEEETTTEEEEEECCCT CS
         NHL   2 nyPhGvavdsnGdiyVaDsenh 23 
                 +yP ++a+ + G+i+ +Ds n+
  EFC38369.1 279 RYPKSIAIGKHGEIFFTDSDNQ 300
                 59*****************996 PP

  == domain 6  score: 25.5 bits;  conditional E-value: 2.5e-09
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                  P+G+avdsnG iy +D++n+rv++
  EFC38369.1 336 KPTGIAVDSNGTIYFCDNNNNRVRK 360
                 6**********************97 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.6      0.96   3.5e+03      10      18 ..     371     379 ..     365     382 .. 0.73
   2 !   23.5   4.0   1.5e-08   5.4e-05       5      30 ..     387     411 ..     383     412 .. 0.83
   3 !   18.3  11.4     6e-07    0.0022       6      30 ..     423     446 ..     419     447 .. 0.86
   4 !   14.2  14.4   1.2e-05     0.043       6      32 .]     458     483 ..     449     483 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.96
       EGF_2  10 ghGtCvnqc 18 
                 ++GtC+ +c
  EFC38369.1 371 VNGTCEFSC 379
                 589997455 PP

  == domain 2  score: 23.5 bits;  conditional E-value: 1.5e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGk 30 
                  + C+ghG C +++  C Cdsg+ G+
  EFC38369.1 387 ATVCNGHGNCLATN-SCLCDSGWKGN 411
                 578*******8666.8*******996 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 6e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C+ghG+Cv +++ C+C++g+ G+
  EFC38369.1 423 NNCNGHGSCV-LNNTCQCQDGWKGN 446
                 67*******9.6779********96 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 1.2e-05
       EGF_2   6 eiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                 ++C+g+G Cv  + + C C sgy+Gk C
  EFC38369.1 458 NNCNGRGACV--GvNTCLCVSGYFGKEC 483
                 78********..5458************ PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   2.2   7.5e-05      0.27       5      31 ..     388     411 ..     382     412 .. 0.84
   2 !   11.2   9.8   9.9e-05      0.35       1      31 [.     419     446 ..     419     447 .. 0.91
   3 !   10.7   6.5   0.00014      0.51       1      31 [.     454     481 ..     454     482 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 7.5e-05
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + C+++G C+ t     +C C++G++G+
  EFC38369.1 388 TvCNGHGNCLATN----SCLCDSGWKGN 411
                 26*******8888....*********97 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 9.9e-05
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  n+C+++G Cv +     tC+C+ G++G+
  EFC38369.1 419 CDGlNNCNGHGSCVLNN----TCQCQDGWKGN 446
                 777688*******9999....*********97 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00014
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   n+C+++G Cv +     tC C +Gy+Gk
  EFC38369.1 454 CERvNNCNGRGACVGVN----TCLCVSGYFGK 481
                 888799*******7777....**********8 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0     0.062   2.2e+02     184     218 ..      51      85 ..      39      96 .. 0.84
   2 ?    0.1   0.0      0.13   4.8e+02     182     216 ..     106     140 ..      94     144 .. 0.84
   3 ?    0.2   0.0      0.13   4.6e+02      11      75 ..     176     258 ..     167     275 .. 0.57
   4 !   11.8   0.0   3.6e-05      0.13     148     212 ..     292     363 ..     279     374 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.062
         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 ++  G+av ++G+v v +   g+v+++d++G +++
  EFC38369.1  51 EYTEGVAVNSKGEVLVVQNFYGRVRKVDKNGYVTT 85 
                 456799***********************998876 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.13
         SGL 182 gegepDGlavDaeGnvwvAvwgggkvvrfdpdGkl 216
                 + g+p G++v  +++++   +g++ v+++  +G++
  EFC38369.1 106 MLGYPAGITVNDKDEIYLVEYGTHMVRKILVNGTI 140
                 348999********************999988875 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.13
         SGL  11 egaLlwvDilgqrihrldpatgketv.................ldtpesvGaiaprkdgrlvvasksglall..dlasgeletl 75 
                 +g ++ +D  ++ri ++d+++  +t+                 ++++++  +++  ++g l++ + ++ +++   +++g+++t+
  EFC38369.1 176 TGDVYISDFSNNRIRKVDSSGIISTYvgtgnteygaddilavnANINSPYYIATG-PNGDLYIPLVGSSRICkvSYSTGKITTI 258
                 5667777777777777777766666555555554544443333222223322222.5555555555555555444555555555 PP

  == domain 4  score: 11.8 bits;  conditional E-value: 3.6e-05
         SGL 148 lYlaDsltrkiwaydvdaeggklsnrrvf.adlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdp 212
                 ++++Ds ++ i ++  d   +++     f + ++ g       ++p G+avD++G ++ +  ++++v+++ p
  EFC38369.1 292 IFFTDSDNQVIRRITPDGIITTIAGTGNFgYSGDGGLatsadiSKPTGIAVDSNGTIYFCDNNNNRVRKLVP 363
                 567999999999999999999999999997777777799888877999999999999999999998887655 PP

>> SdiA-regulated  SdiA-regulated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.037   1.3e+02     217     240 ..      45      68 ..      36      71 .. 0.83
   2 ?   -1.0   0.1      0.24   8.5e+02     225     239 ..     110     124 ..      96     126 .. 0.84
   3 ?    6.4   0.0    0.0013       4.7     219     239 ..     331     351 ..     322     357 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.037
  SdiA-regulated 217 gLeedipqaEGvamDeegnlYivs 240
                      ++ +++  EGva++++g++ +v+
      EFC38369.1  45 AVNAKVEYTEGVAVNSKGEVLVVQ 68 
                     56789999***********99997 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.24
  SdiA-regulated 225 aEGvamDeegnlYiv 239
                     + G+++++++++Y+v
      EFC38369.1 110 PAGITVNDKDEIYLV 124
                     67***********99 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0013
  SdiA-regulated 219 eedipqaEGvamDeegnlYiv 239
                     + di ++ G+a+D++g++Y  
      EFC38369.1 331 SADISKPTGIAVDSNGTIYFC 351
                     5789***************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (520 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.46u 0.24s 00:00:00.70 Elapsed: 00:00:00.39
# Mc/sec: 3979.81
//
Query:       EFC38370.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0047   16.7   0.5     0.0047   16.7   0.5    1.7  2  DUF975    Protein of unknown function (DUF975)
  ------ inclusion threshold ------
      0.015   15.8   0.8       0.03   14.8   0.8    1.5  1  DUF1218   Protein of unknown function (DUF1218)


Domain annotation for each model (and alignments):
>> DUF975  Protein of unknown function (DUF975)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.2      0.12     1e+03      24      50 ..       2      28 ..       1      65 [. 0.53
   2 !   16.7   0.5   5.3e-07    0.0047      54     128 ..     118     199 ..      78     203 .] 0.65

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.12
      DUF975 24 LllLlillvevllsflisiietilvss 50
                L++L++l  +v  ++  +++++i +s 
  EFC38370.1  2 LIVLILLTFNVQYTESTESTGVIATSN 28
                334444443334444444444444433 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 5.3e-07
      DUF975  54 l........livlllgtlltlsavfvviklvkrkekvelkeslasfkeknfiklLvllllkelflllwslial.lglliiiisl 128
                 l           ++lg l+ +  + ++ kl +r++k++l +  a  k +   k ++++  ++++ll+w+++++ l +++i+i l
  EFC38370.1 118 LiclgillvEFCCFLGALFYSIGSCCCCKLGERDQKFRLDNYGAWAKDHEKRKRIICA--FRIILLIWVILNIaLLMYVIFINL 199
                 3555555434456888889999999****************99999887777777776..455555555554313334444433 PP

>> DUF1218  Protein of unknown function (DUF1218)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.8   3.3e-06      0.03       9      55 ..     134     195 ..     127     199 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 3.3e-06
     DUF1218   9 qiiasvasgclccrkekspssa................krtlavvlfvlswivfaiAvalllv 55 
                 ++    ++ c+cc+ ++++++                 + ++a  + +l w+++ iA++++++
  EFC38370.1 134 ALF-YSIGSCCCCKLGERDQKFrldnygawakdhekrkRIICAFRIILLIWVILNIALLMYVI 195
                 444.4458999999988888878899*********9755556666666777777777777654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1020  (0.0568911); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.35u 0.20s 00:00:00.55 Elapsed: 00:00:00.34
# Mc/sec: 1778.51
//
Query:       EFC38371.1  [L=143]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.021   14.1   0.2      0.026   13.8   0.2    1.2  1  ATLF         Anthrax toxin lethal factor, N- and C-terminal d
      0.053   13.6   0.4      0.075   13.1   0.4    1.4  1  Baculo_LEF5  Baculoviridae late expression factor 5


Domain annotation for each model (and alignments):
>> ATLF  Anthrax toxin lethal factor, N- and C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.2   2.9e-06     0.026     141     200 ..      53     108 ..      38     126 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.9e-06
                 HHHTCCTSCSCCCHCCHHHHCCSSSSSCTCCCCTHHHHHHHHHHHHHHHHSSSHHHHHHH CS
        ATLF 141 elkdavDsdssDLlFidkfkeegsdlsveflkeneaefqevFakaFayyispdhRlvlql 200
                 +l +++D+d++ ++ + ++ e+++ ++ ++l +n+ e    +a+a++     + R  l++
  EFC38371.1  53 TLINSSDNDQQQVILT-QLGENPKTVDTDYLMQNLIER---YARAWSSKERKQIRANLDR 108
                 4667899999998876.69****************999...9999998888888877765 PP

>> Baculo_LEF5  Baculoviridae late expression factor 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.4   8.4e-06     0.075      50      83 ..      89     123 ..      43     138 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 8.4e-06
  Baculo_LEF5  50 ayvPsssdkerkqirldeekleklaent.kndfkl 83 
                   y  + s kerkqir + +++ kl en   n+   
   EFC38371.1  89 RYARAWSSKERKQIRANLDRMVKLNENVlDNNTES 123
                  57788899****************99862455444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (143 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       886  (0.0494171); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.24s 00:00:00.64 Elapsed: 00:00:00.42
# Mc/sec: 1026.96
//
Query:       EFC38372.1  [L=537]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-92  308.7   2.6    7.8e-92  307.7   2.6    1.4  1  PhoPQ_related  PhoPQ-activated pathogenicity-related protein


Domain annotation for each model (and alignments):
>> PhoPQ_related  PhoPQ-activated pathogenicity-related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  307.7   2.6   4.4e-96   7.8e-92       2     366 .]      36     416 ..      35     416 .. 0.92

  Alignments for each domain:
  == domain 1  score: 307.7 bits;  conditional E-value: 4.4e-96
  PhoPQ_related   2 kdyvekedeelkyeltetkelegvtiyileltSQkWske.klvdpslwkHkltivvPke.kkleetalllisggsnenvkkkskesesetlaeiar 95 
                    +dyv+ ++++++y+l +t++l++  +y+l++   +W ++ +l + s+wkH l+ivvP++ +++ ++++l+i+ggs    +++s+++++++l+++a 
     EFC38372.1  36 DDYVNLSSPAMNYTLLATTTLDVGVMYTLSIRGVDWLTSeELGSSSQWKHYLAIVVPNNlNTNYNESFLYIEGGS----SSTSMPTTNDMLKSLAY 127
                    79**********************************8651567888*************88999***********....6677788999******* PP

  PhoPQ_related  96 etkavvaelsdvPnqpltfeddgk..arkEDdlvAytwrkfle..eekde..........tlplllpmtkaavraMdlvqeflkel.klkiekFvv 176
                    +t++++ +++ vPnqp++f+ d++  ar+ED l+Aytw+ f++  e+k +          +++ +lpm+k  +raMd+vq+f+ +l +++i kF++
     EFC38372.1 128 STNSITSQVYIVPNQPIIFSSDPSktARSEDSLIAYTWNAFMDryENKSSanlpidvktyEWLGHLPMAKTSMRAMDVVQDFIYKLnGVSISKFTI 223
                    ********************99764589**************9753222122222222227999********************999********* PP

  PhoPQ_related 177 sGaSKRGWttwltaivDkrvkaivPvvidilnlekqlkhqlkaYGewslaledYvaegidellktpefkkLlkivDplsYlerl.tipkyiinasg 271
                     G SKRGW++wl++++D+rvka+vP++i++lnl++++ ++ k+  +w++al+dY ++g+ + +++++f++L +++Dp+ Y+er+ +   y+ina g
     EFC38372.1 224 GGGSKRGWAAWLVGAADPRVKALVPLSIQVLNLKESFLQINKSLCAWPIALYDYNSQGVLKRVDSAAFTALQSVEDPFAYRERFsNHSIYMINALG 319
                    ************************************************************************************8999******** PP

  PhoPQ_related 272 DdffvpdstkfyfekLkg..ekalrivPnssHglsnkevveslvafvklvaagkelPeleweieesegtiklkvksseapekvklwtatnesarDf 365
                    D+f  pd +   +  ++   +k+lr++Pn++H+lsn++++es+  f+ + ++g +lP+++++  ++++ +k++v s  +p++v+lw+a+n++arDf
     EFC38372.1 320 DEFMWPDLALKSWPYMNNikKKYLRYIPNTGHSLSNSDAIESVLLFYYMQVKGIDLPQYNFTHIYNDTGVKVTVWSAIKPTNVYLWRANNTNARDF 415
                    *******776666555544489*********************************************9**************************** PP

  PhoPQ_related 366 R 366
                    R
     EFC38372.1 416 R 416
                    9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (537 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       782  (0.0436165); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 3371.89
//
Query:       EFC38373.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.14   12.6   0.0        1.6    9.2   0.0    2.4  2  SHS2_FTSA  SHS2 domain inserted in FTSA


Domain annotation for each model (and alignments):
>> SHS2_FTSA  SHS2 domain inserted in FTSA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.0     9e-05       1.6      40      69 ..      93     122 ..      85     129 .. 0.84
   2 ?    0.2   0.0     0.057     1e+03      35      56 ..     257     278 ..     235     282 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 9e-05
                 TTEEEEEEEEEEEEETTTEEESB-TT-EES CS
   SHS2_FTSA  40 edreilhvipqeyivDgqegikdPvGmsGv 69 
                 e++  +h+    y++D+ +++++Pv + G+
  EFC38373.1  93 EKENNIHINTSAYKLDHDDNVSEPVSWGGD 122
                 566779*******************98776 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.057
                 ...CHTTEEEEEEEEEEEEETT CS
   SHS2_FTSA  35 avaipedreilhvipqeyivDg 56 
                 +v+  ++r  + + p +y++D+
  EFC38373.1 257 KVRNAAKRNSITARPHSYVLDN 278
                 4555678889999999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       698  (0.0389313); expected 358.6 (0.02)
Passed bias filter:                      247  (0.0137766); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.51
# Mc/sec: 2684.77
//
Query:       EFC38374.1  [L=819]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-24   86.9   0.7    2.2e-24   86.2   0.0    1.7  2  Pyr_redox_2    Pyridine nucleotide-disulphide oxidoreductase
    0.00034   19.8   0.0     0.0017   17.5   0.0    1.9  2  FAD_binding_2  FAD binding domain
     0.0012   19.4   0.9       0.37   11.4   0.0    3.6  3  Pyr_redox      Pyridine nucleotide-disulphide oxidoreductase
  ------ inclusion threshold ------
      0.011   15.6   0.3       0.93    9.5   0.0    3.0  2  Rubredoxin_C   Rubredoxin NAD+ reductase C-terminal domain
      0.017   14.3   0.2        3.9    6.5   0.0    2.9  3  K_oxygenase    L-lysine 6-monooxygenase (NADPH-requiring)
        1.3    9.1   3.6        1.5    8.8   0.0    2.6  2  DUF5345        Family of unknown function (DUF5345)


Domain annotation for each model (and alignments):
>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.2   0.0   7.4e-28   2.2e-24       2     294 .]      28     423 ..      27     423 .. 0.81
   2 ?   -3.5   0.1       1.6   4.6e+03      52     225 ..     749     774 ..     713     810 .. 0.47

  Alignments for each domain:
  == domain 1  score: 86.2 bits;  conditional E-value: 7.4e-28
                  SEEEE--SHHHHHHHHHHHH.....HTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHH............HHHHCHHHHCCCCHCCTCEEEEESC CS
                  xxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............xxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaq.....agakvtlvelegtclnggcllskallgvaedaeias............evvkklnqgielllgeevvkidpgk 82 
                   +vviGgG  Gl++ + +++     +++k++l+ +e+ c     +   ++l++ +++                  ++k++ + ++l +++v++i + +
   EFC38374.1  28 TMVVIGGGYSGLSFIQSIREiekqeKQYKIILITREDFCSRPNLFFRFKFLQWHSKHL--DyfggihlngennSFITKYGVD-QVLFNTSVFDINNVE 122
                  579******************99999*******7777666666666555555544442..1235888888877556666666.7777788****9999 PP

                  EEEEETEEECTCEEEEEESEEEE---EEE-BCTCTTC..........................TTBEECCSECHHHHHHCCSS-T............. CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........................xxxxxxxxxxxxxxxxxxxxxxx............. RF
  Pyr_redox_2  83 kkvklekkkegdeekiaydklvlAtGssprdlgipGv.........................aenvgklvrtldsaealklkllp............. 142
                  + +k+++  ++de ++ yd+l l++G++++  + p +                           n+   +r+++++e++++ +++             
   EFC38374.1 123 QVIKYKTVGSDDEISLHYDTLCLCIGGKAHVVNYPTEvsneksviglnreqlivnfgeiqsqISNY-LYIRNIEQVEYIHQLMKQlydyyesnennld 219
                  8888876667**********************999777999******************9964444.4559999999999999999999999999999 PP

                  .SEEEEES-SHHHHHHHHHH....HHHT-............................EEEEEESSSSSS.TTS.-HHHHHHHHHHHHHT.T..EEEEE CS
                  .xxxxxxxxxxxxxxxxxxx....xxxxx............................xxxxxxxxxxxx.xxx.xxxxxxxxxxxxxxx.x..xxxxx RF
  Pyr_redox_2 143 .krivvvGgGyiGvElAaal....aklgk............................evtlveardrll.ral.dkelsaaleealeke.G..vevkl 202
                   +riv++G+G  ++++ +++      + k                            ++t++ ++++l  + l d+++ +++ +  +++ G   +++l
   EFC38374.1 220 hNRIVIIGSGTLSIDIVSHIiegyEAIEKllngeasaqpskqtieevwsikntnilpKITIIGRGKHLGkSLLrDEAACDMILKLAKEKyGkyLDIQL 317
                  ****************99953333333337778888888999999999999999999***********97443244444555555555446669**** PP

                  SCEEEEEEETTE.EEE.EEETTSCEEEESEEEE-S-EEES-HHCSHCCT-EEEETTEEE--TTS......BESSTTEEE-GGGC......TECCSS-- CS
                  xxxxxxxxxxxx.xxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxx......xxxxxxxx RF
  Pyr_redox_2 203 gtsvkeidgnge.kle.vvledgeeidadlvvvavGvrpstelleeklglelderggivvdefl......rtnvpgiyaiGDva......ggkggpel 286
                  +t+v+ i   +  +l   v +++  i+++l+v avGv  +t+l+++ l   l  +ggi+vde+        t vp+iy iGD+a      g+++++++
   EFC38374.1 318 ETQVESILYSDVnNLAhSVKTSNGIIPCSLIVQAVGVNSETSLATKCLDASLGVNGGILVDEHFqihtnnSTIVPNIYCIGDCAeittqeGKTNVWKN 415
                  *****999888883444455555559*****************99889999999**********555443356****************9999***** PP

                  HHHHHHHH CS
                  xxxxxxxx RF
  Pyr_redox_2 287 aqaAvqqG 294
                  ++ A +q+
   EFC38374.1 416 WTSAREQA 423
                  ****9987 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.6
                  HHHHHH...HHHHCHHHHCCCCHCCTCEEEEESCEEEEETEEECTCEEEEEESEEEE---EEE-BCTCTTC.TTBEECCSECHHHHHHCCSS-TSEEE CS
                  xxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2  52 daeias...evvkklnqgielllgeevvkidpgkkkvklekkkegdeekiaydklvlAtGssprdlgipGvaenvgklvrtldsaealklkllpkriv 146
                  + e+ +   e++++l  ++el +g                                                                          
   EFC38374.1 749 RVEEHKkefEKLTELIFSVELETG-------------------------------------------------------------------------- 772
                  332222222222222222222222.......................................................................... PP

                  EES-SHHHHHHHHHHHHHT-EEEEEESSSSSSTTS-HHHHHHHHHHHHHTTEEEEESCEEEEEEETTEEEEEEETTSCE CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 147 vvGgGyiGvElAaalaklgkevtlveardrllraldkelsaaleealekeGvevklgtsvkeidgngeklevvledgee 225
                                                                                               ++
   EFC38374.1 773 -----------------------------------------------------------------------------KV 774
                  .............................................................................22 PP

>> FAD_binding_2  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.17   5.2e+02       2      13 ..      29      40 ..      28      62 .. 0.92
   2 !   17.5   0.0   5.7e-07    0.0017     359     402 ..     358     401 ..     284     409 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.17
                   EEEE--SHHHHH CS
  FAD_binding_2  2 viViGsGlAGLa 13
                    +ViG+G +GL+
     EFC38374.1 29 MVVIGGGYSGLS 40
                   69********97 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 5.7e-07
                    ......EEEEEEEES-EEEBETTSBESTTEEESSBTEEE-STCE CS
  FAD_binding_2 359 pfyavkvvpaqhytmgGvetdengrvldadgqpipGLYAaGeva 402
                    +  a+k   a+++  gG+ +de+++   ++ +++p+ Y++G +a
     EFC38374.1 358 TSLATKCLDASLGVNGGILVDEHFQIHTNNSTIVPNIYCIGDCA 401
                    4567888899999******************************9 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.0   0.00012      0.37       2      24 ..      29      51 ..      28      67 .. 0.77
   2 ?    0.6   0.1      0.28   8.3e+02       1      14 [.     222     235 ..     222     241 .. 0.86
   3 ?    3.2   0.0     0.045   1.3e+02      23      76 ..     276     336 ..     265     341 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00012
                EEEECSSHHHHHHHHHHHHTTSE CS
   Pyr_redox  2 vvvvGgGyiglElAgalaelgkk 24
                +vv+GgGy+gl + + ++e+ k+
  EFC38374.1 29 MVVIGGGYSGLSFIQSIREIEKQ 51
                79***************999853 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.28
                 EEEEECSSHHHHHH CS
   Pyr_redox   1 kvvvvGgGyiglEl 14 
                 ++v++G+G++ ++ 
  EFC38374.1 222 RIVIIGSGTLSIDI 235
                 79******998875 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.045
                 SEEEEEESSSSSS..TTSSHHHHHHHHHHHHHT...TEEEECSEEEEEEEEETTS..EEEE CS
   Pyr_redox  23 kkVtvversdkll..rllDeeaskilqeklekn...gievllntkveeiegsedg..vesv 76 
                  k+t++ r+++l    l De+a +++ +  +++     ++ l+t+ve+i  s+ +    sv
  EFC38374.1 276 PKITIIGRGKHLGksLLRDEAACDMILKLAKEKygkYLDIQLETQVESILYSDVNnlAHSV 336
                 5899******9998555588888888888888898889**********9966654344555 PP

>> Rubredoxin_C  Rubredoxin NAD+ reductase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0      0.04   1.2e+02      24      44 ..      42      62 ..      34      65 .. 0.87
   2 ?    9.5   0.0   0.00031      0.93       6      54 ..     445     499 ..     441     509 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.04
                  SEEEEEE-SS-..EEEEEEET CS
  Rubredoxin_C 24 aeelveedkekgkYkklfikn 44
                  +++++e++k++++Yk ++i +
    EFC38374.1 42 IQSIREIEKQEKQYKIILITR 62
                  5789*************9976 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00031
                   EETTEEEEEES--TT---..SEEEEEE-SS-..EEEEEEE....TTEEEEEEEES CS
  Rubredoxin_C   6 kvsgidlfSvGdieeeek..aeelveedkekgkYkklfik....ngklvGAiliG 54 
                   k++g+ ++ +G+ +  ++   +++ +e+ +k++Y k +++    + +l+GA +iG
    EFC38374.1 445 KFFGLHITCLGEYDSTDSnlQTIVIDEQIQKNIYMKFLFNtigeQYQLIGALIIG 499
                   99***************9955555566667889***9995333267999999998 PP

>> K_oxygenase  L-lysine 6-monooxygenase (NADPH-requiring)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0    0.0057        17     187     226 ..      22      64 ..       2      70 .. 0.69
   2 ?   -2.3   0.0      0.61   1.8e+03     112     165 ..     108     156 ..     105     168 .. 0.69
   3 ?    6.5   0.0    0.0013       3.9     180     216 ..     209     245 ..     191     331 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.0057
  K_oxygenase 187 ellakkriaVvGsGqSaaeifedllrr...qkkvelklvtrse 226
                  ++   k+++V+G+G S+   ++ + +    +k++++ l+tr++
   EFC38374.1  22 SSTPLKTMVVIGGGYSGLSFIQSIREIekqEKQYKIILITRED 64 
                  45666899*********99887765543225569999999876 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.61
  K_oxygenase 112 qvrfgeeveevepdeeeeeelltveskdaegeeeelearnlvlgvGtepkiPev 165
                  qv f+++v +++ +e+   ++ tv     +++e +l+  +l+l +G+++++ + 
   EFC38374.1 108 QVLFNTSVFDINNVEQVI-KYKTVG----SDDEISLHYDTLCLCIGGKAHVVNY 156
                  588999999999888642.222333....4678899999999999999887555 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0013
  K_oxygenase 180 eylerkeellakkriaVvGsGqSaaeifedllrrqkk 216
                  +y e++e++l+++ri+++GsG    +i+ ++++ +++
   EFC38374.1 209 DYYESNENNLDHNRIVIIGSGTLSIDIVSHIIEGYEA 245
                  677888899*********************9998765 PP

>> DUF5345  Family of unknown function (DUF5345)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.0   0.00051       1.5      13      57 ..     604     647 ..     598     654 .. 0.75
   2 ?   -0.9   1.2      0.55   1.6e+03      21      39 ..     800     817 ..     792     819 .] 0.57

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00051
     DUF5345  13 evetPsleeleqllaeekerkrkrlrrElllFlliAllilsllll 57 
                 + ++Ps ++  ++l + + +++    r l++Fl+iA+l+  ll +
  EFC38374.1 604 STSSPSSNDTVHML-NISHKQKMSSLRNLIIFLSIAILVAVLLPS 647
                 44558888888888.66778899999**********987555544 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.55
     DUF5345  21 eleqllaeekerkrkrlrr 39 
                 e ++ ++ee+ +++k+ + 
  EFC38374.1 800 EYKKAVEEEQ-ERKKKKIE 817
                 5556665555.55555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (819 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1716  (0.0957109); expected 358.6 (0.02)
Passed bias filter:                      644  (0.0359195); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.81u 0.29s 00:00:01.10 Elapsed: 00:00:00.47
# Mc/sec: 5226.42
//
Query:       EFC38375.1  [L=130]
Description: autophagy protein 12 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-25   87.8   0.0    6.1e-25   87.5   0.0    1.2  1  APG12     Ubiquitin-like autophagy protein Apg12
  ------ inclusion threshold ------
       0.06   13.6   0.0      0.074   13.3   0.0    1.2  1  Atg8      Autophagy protein Atg8 ubiquitin like


Domain annotation for each model (and alignments):
>> APG12  Ubiquitin-like autophagy protein Apg12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.5   0.0   6.8e-29   6.1e-25       1      87 []      42     130 .]      42     130 .] 0.95

  Alignments for each domain:
  == domain 1  score: 87.5 bits;  conditional E-value: 6.8e-29
                 EEEEEEEEETTS---S--EEEEETTSBHHHHHHHHH.HHCT-.S.SSS-EEEETTTB---TTSBHHHHHHHH-BTTEEEEEEESSS--- CS
       APG12   1 kitirlkaigdvpilkkkklkvnasdtvakvilflk.keLklqa.seslflYvnnsFaPsPdeeveeLyecfgtdkklvlnYcisvAfG 87 
                 k+ i+++a+g++pilkkkk+++ a+ ++++vi fl+ k L+++  ++ lflY  ++F P+Pd+ v++L++ f+t++ lv+nY+ + A+G
  EFC38375.1  42 KVMILFQAVGSAPILKKKKYTIGAASSFNTVIAFLRdKLLRITNpNQTLFLYCGQAFCPNPDDYVGDLFDHFNTNGMLVINYSLKIAWG 130
                 899********************************9567788653788****************************************9 PP

>> Atg8  Autophagy protein Atg8 ubiquitin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   8.2e-06     0.074      29     104 .]      53     130 .]      34     130 .] 0.81

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 8.2e-06
                 S---S-SEEEEETTSBHHHHHHHHHHHT.T.--TTS-EEEEETT.E-SSTTSBHHHHHHHH--TTSSEEEEEESSSTB- CS
        Atg8  29 lpeldkkkylvPedltvgqlvliirkrl.q.lepekalfllvne.tlpstsatmsalyeeekdedgflyvvyssentfG 104
                  p l kkky + +  +   ++  +r +l +  +p+++lfl+  +   p+    +++l++ + + +g+l + ys + ++G
  EFC38375.1  53 APILKKKKYTIGAASSFNTVIAFLRDKLlRiTNPNQTLFLYCGQaFCPNPDDYVGDLFD-HFNTNGMLVINYSLKIAWG 130
                 57899*****************999876232489********99345666788999997.5678899999999877766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       776  (0.0432818); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.27s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 918.97
//
Query:       EFC38376.1  [L=396]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      1e-05   25.6   0.3    4.9e-05   23.4   0.1    2.4  2  UBX            UBX domain
  ------ inclusion threshold ------
       0.24   11.8   2.5       0.61   10.4   0.5    2.3  2  NLRC4_HD       NLRC4 helical domain
        3.2    8.0  18.3        1.4    9.2  12.7    2.1  2  Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
        4.4    8.0   9.3       0.14   12.8   1.4    2.5  3  DnaI_N         Primosomal protein DnaI N-terminus


Domain annotation for each model (and alignments):
>> UBX  UBX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.78   3.5e+03      32      54 ..      32      60 ..      21      80 .. 0.62
   2 !   23.4   0.1   1.1e-08   4.9e-05       5      69 ..     296     370 ..     292     390 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.78
                HHHHHHHHCCCCCTS......EEEEETTT CS
         UBX 32 vyeyVdsklfekeep......FqLltsfP 54
                v+e +++++  ++++      +++++++P
  EFC38376.1 32 VREQIQQQAIAQNNQslqdliVDIISHLP 60
                55556666555555555555555555555 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 1.1e-08
                 SEEEEEEEETTSTEEEEEEESSSBHHHHHHHHHHHCCCCCTS.........EEEEET.TTTEEGGCCCCSBCCCC CS
         UBX   5 datrlqiRlpdGsrlvrrFkksdtlesvyeyVdsklfekeep.........FqLlts.fPrreltksdkktLsdl 69 
                 +  +++++lp+G+  +r+F+ + +  ++  ++     ++ +p         ++L  + fP+r++  +d++tLs +
  EFC38376.1 296 EYKNIKLKLPNGTEVQRKFSLDLSFGDLHRFIHAYPSTEWQPsrysnvetdYELTLNsFPKRPIPFDDSQTLSSI 370
                 56789****************************999999999999******9996544*******99999*9977 PP

>> NLRC4_HD  NLRC4 helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.5   0.00014      0.61      29      96 ..      23      96 ..       4      98 .. 0.74
   2 ?    0.3   0.1       0.2   8.9e+02      64      96 ..     185     217 ..     170     227 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00014
                HCCC--TTCHHHHHHHHHHTTSSSTHHCHCH........T--SGGCCHCHHHHHHH.HHHHHHHH-HHHHHHHHHH CS
    NLRC4_HD 29 YtcgsstkAgpkivshLlalvdekeslenls........endeylkhtpelellkailirslvelspelylssvsk 96
                ++  +s +++++ ++   a++++++sl++l           +e l++++e+  +++ ++ s+ el+p+l+++s+++
  EFC38376.1 23 FAANPSETVVREQIQQ-QAIAQNNQSLQDLIvdiishlpSVEEILTQHNETVNEEH-ITTSIHELIPQLFDKSFKE 96
                3444555555555544.457888899999999999999888889999999988888.***************9987 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.2
                 GGCCHCHHHHHHH.HHHHHHHH-HHHHHHHHHH CS
    NLRC4_HD  64 ylkhtpelellkailirslvelspelylssvsk 96 
                 +lk+ +e++  + ++i+ l++  +e+   + s+
  EFC38376.1 185 ELKNLTEMSNGQTHVIDNLMTQLIEVHERLDSQ 217
                 689999999999999999999999876555444 PP

>> Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.3     0.049   2.2e+02      21      66 ..      45      89 ..      33      98 .. 0.80
   2 ?    9.2  12.7    0.0003       1.4      21     108 ..     197     284 ..     184     303 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.049
  Jnk-SapK_ap_N 21 eevvkgLmPkvVkvLElLeslasrneeeeaeleelreeleqLetey 66
                   ++++++L+  +++ L ++e++++++ +e++++e     + +L  ++
     EFC38376.1 45 NQSLQDLIVDIISHLPSVEEILTQH-NETVNEEHITTSIHELIPQL 89
                   5788999999999999999999998.77788888888888887765 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0003
  Jnk-SapK_ap_N  21 eevvkgLmPkvVkvLElLeslasrneeeeaeleelreeleqLeteyerekelrkraeeeleeiedqweeerkelqekveqleeenrel 108
                    + v+++Lm+++++v E L+s +  +++e+ + e  r+++e+    ye+     +++ee+ + +e + + +  ++ +k+  +e+ ++ +
     EFC38376.1 197 THVIDNLMTQLIEVHERLDSQLVIQRQEKLQREYERRAREEQDRAYEESLRIDREKEEKRLAVERERQAKVDAFMKKLRINESTRNDI 284
                    6799****************************************************************99999999999888776655 PP

>> DnaI_N  Primosomal protein DnaI N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   1.4   3.2e-05      0.14       5      58 ..      33      86 ..      30     107 .. 0.85
   2 ?   -1.4   0.3      0.86   3.9e+03      34      59 ..     204     228 ..     186     255 .. 0.67
   3 ?   -1.9   0.1       1.2   5.6e+03      31      46 ..     264     277 ..     247     305 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.2e-05
                TXSXXXXSXXXHHHHHHHHHHHHHTTX.HHHHHHHHHSTTTC-HHHHHHTHHHHH CS
      DnaI_N  5 geslkkllkkrkfekryeklkeevlsd.peVqaFlqehqeelteeaierslskLy 58
                +e++++     + ++++++l+ +++s+ p+V++ l +h+e+++ee i+ s+ +L 
  EFC38376.1 33 REQIQQ-QAIAQNNQSLQDLIVDIISHlPSVEEILTQHNETVNEEHITTSIHELI 86
                566677.5566777899999999998879*********************99985 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.86
                 HHHHHHHSTTTC-HHHHHHTHHHHHH CS
      DnaI_N  34 VqaFlqehqeelteeaierslskLye 59 
                   ++++ h++ l+++ + ++  kL+ 
  EFC38376.1 204 MTQLIEVHER-LDSQLVIQRQEKLQR 228
                 5566666664.777766666666653 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.2
                 XHHHHHHHHHSTTTC- CS
      DnaI_N  31 dpeVqaFlqehqeelt 46 
                 +++V aF+++ +  ++
  EFC38376.1 264 QAKVDAFMKKLR--IN 277
                 556666666655..22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (396 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1753  (0.0977746); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2375.67
//
Query:       EFC38377.1  [L=406]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-09   37.6   1.4    1.2e-07   32.0   1.4    3.2  1  YqaJ      YqaJ-like viral recombinase domain


Domain annotation for each model (and alignments):
>> YqaJ  YqaJ-like viral recombinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.0   1.4   6.6e-12   1.2e-07       1     147 [.      85     307 ..      85     308 .. 0.72

  Alignments for each domain:
  == domain 1  score: 32.0 bits;  conditional E-value: 6.6e-12
        YqaJ   1 kWldaRrkgisaSdfaaalg.tsrvsd.svrllldkvgtaiaeehef.......................................kenaftawGtelE 58 
                 kWl++R ++i+aS++++alg  s+     ++l ++  ++ ++                                             ++ f+ wG ++E
  EFC38377.1  85 KWLELRSNRITASRLSKALGfFSPAAVkMLDLSKSFLKQDKE----TvgtiyesiltrdelkelgmtdeeidqlkqpsnenpkeeiVKRVFMDWGSNHE 179
                 7*******************7776655455555555555443....24556777899999**************************99*********** PP

        YqaJ  59 .plaraeyelatg..............dkvrd.......sgglfes.....psdkflgaspDgiishasid.alkrrllEikspf..ealyvstklgrq 127
                  + + +  +   +              d++++       +     +     ++ + lgaspDg+   +sid +    ++Eik+p      yv+++    
  EFC38377.1 180 lNCVSTILNSHFDydmfcetgfyiiteDRLNQvftkedlE-----KyelsfEKLPALGASPDGLL--QSIDtNEIHSCVEIKCPTcfVEKYVKKEDR-- 269
                 4456666666666667777777777663333344333331.....144445699***********..444446889********7224455554443.. PP

        YqaJ 128 e...ei...............peeYmcQiqgqlavtga 147
                 e    i               p +Y++Q+  q+  t++
  EFC38377.1 270 EsgrDIpltfsyikkkpheevPVYYIPQMYLQMIATNT 307
                 145733555566777777777************98875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (406 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       974  (0.0543254); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.35s 00:00:01.08 Elapsed: 00:00:00.58
# Mc/sec: 2109.86
//
Query:       EFC38378.1  [L=422]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-25   88.6   0.2    1.3e-24   86.2   0.0    2.3  3  ACP_syn_III_C    3-Oxoacyl-[acyl-carrier-protein (ACP)] synth
    3.4e-14   52.4   0.1    3.4e-13   49.2   0.0    2.5  3  ACP_syn_III      3-Oxoacyl-[acyl-carrier-protein (ACP)] synth
    1.2e-05   24.9   0.1    2.6e-05   23.7   0.0    1.7  2  Chal_sti_synt_N  Chalcone and stilbene synthases, N-terminal 
     0.0013   17.5   0.1      0.012   14.4   0.0    2.1  2  SpoVAD           Stage V sporulation protein AD (SpoVAD)
     0.0025   17.2   0.4      0.033   13.5   0.0    2.3  2  Thiolase_N       Thiolase, N-terminal domain
  ------ inclusion threshold ------
      0.093   12.5   0.0       0.16   11.7   0.0    1.3  1  PCMT             Protein-L-isoaspartate(D-aspartate) O-methyl


Domain annotation for each model (and alignments):
>> ACP_syn_III_C  3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.4   4.1e+03      22      44 ..      97     119 ..      95     120 .. 0.80
   2 ?   -2.2   0.0       1.7     5e+03       1      15 [.     154     168 ..     154     171 .. 0.86
   3 !   86.2   0.0   4.3e-28   1.3e-24      11      85 ..     343     417 ..     337     422 .] 0.95

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.4
                    HHHHHHHHHHT--GGGB--THHH CS
  ACP_syn_III_C  22 riidavakklglpeekvvvnlde 44 
                    r  ++v + l +++ek+++n+d+
     EFC38378.1  97 RWANSVEHVLTVRKEKFAKNVDQ 119
                    5566778889999******9987 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.7
                    HHHTT--GGG-SEEE CS
  ACP_syn_III_C   1 Lekagltpedidalv 15 
                    L++a+l++ed+d++v
     EFC38378.1 154 LKNANLKVEDLDLIV 168
                    67899******9987 PP

  == domain 3  score: 86.2 bits;  conditional E-value: 4.3e-28
                    -SEEEE-SSSHHHHHHHHHHHT--GGGB--THHHH-B-GGGHHHHHHHHHHHTTSS-TT-EEEEEEEETTTEEEE CS
  ACP_syn_III_C  11 idalvphqanlriidavakklglpeekvvvnldeyGntsaasiplaLdeaveegklkpgdlvllvgfGaGltwga 85 
                    +d+ vphqa++  ++a+ + +g+p++++v++l+++Gnt +asip+aL eav++g++k+gd+vll+g+GaGlt g 
     EFC38378.1 343 FDWAVPHQASHAAFHAMSEIFGWPKDRIVKTLEKFGNTISASIPMALYEAVQDGRIKRGDRVLLIGTGAGLTTGL 417
                    79**********************************************************************985 PP

>> ACP_syn_III  3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.38   1.1e+03      24      43 ..     100     119 ..      98     128 .. 0.83
   2 !   49.2   0.0   1.2e-16   3.4e-13       3      74 ..     201     274 ..     199     280 .. 0.87
   3 ?   -2.3   0.0       1.4   4.1e+03      21      34 ..     398     409 ..     384     412 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.38
                  TS-SEEEEEEEEEGGGCS-T CS
  ACP_syn_III  24 gaakrvLvigaetlskilDw 43 
                  +++++vL +  e+++k +D+
   EFC38378.1 100 NSVEHVLTVRKEKFAKNVDQ 119
                  57899***********9997 PP

  == domain 2  score: 49.2 bits;  conditional E-value: 1.2e-16
                  EE-GGGHHHHHHHHHHHHHHTTS-SEEEEEEEEEGGGCS-TTT.HHHHTTB-EEEEEEEEEEE.SSSSCEEEEE CS
  ACP_syn_III   3 lnaaCsgfvyalsvAdaliesgaakrvLvigaetlskilDwkd.rstavlfGDGAgAvvleas.eeegarilds 74 
                  + ++C +f++a ++ ++liesg+++++L++++e+ +  l++++      l GDGA+Avvl++s  e+++r+ ++
   EFC38378.1 201 VHSTCLSFMVAFHMCAGLIESGMYEKILIVSTEISTVGLNFEQnPHAGGLIGDGAAAVVLTKSkPEDKSRLTKY 274
                  5689*************************************86477888**************75555566555 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.4
                  HHTTS-SEEEEEEE CS
  ACP_syn_III  21 iesgaakrvLviga 34 
                  i+ g   rvL+ig+
   EFC38378.1 398 IKRG--DRVLLIGT 409
                  4555..78999987 PP

>> Chal_sti_synt_N  Chalcone and stilbene synthases, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0   8.8e-09   2.6e-05      97     221 ..     140     260 ..      57     265 .. 0.82
   2 ?   -2.9   0.0       1.2   3.7e+03      98     122 ..     346     371 ..     339     391 .. 0.81

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 8.8e-09
  Chal_sti_synt_N  97 aevlklgkeaalkalkewGrPkskithlvfvs.ssevelPGadlklakklGlrpsvkrvmlyflGcygGatvlrlakdiaennkGarvlvvase 189
                        +  +g++aal+alk+    ++++  +v  s + +  +P +  ++ k lGl +s k     +  c +   ++ +   + e     ++l+v++e
       EFC38378.1 140 ITISWMGAQAALEALKNANLKVEDLDLIVNASgTPQRTIPDTSCFIHKELGLGDSGKPSLSVHSTCLSFMVAFHMCAGLIESGMYEKILIVSTE 233
                      346679***********************9983557789******************************************************* PP

  Chal_sti_synt_N 190 itvlgfrgPskdrlddlvGaalfGdGaaavii 221
                      i+ +g+    + +        l GdGaaav++
       EFC38378.1 234 ISTVGLNFEQNPHAG-----GLIGDGAAAVVL 260
                      *****9887777765.....4678*****987 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.2
  Chal_sti_synt_N  98 evlklgkeaalkalke.wGrPkskit 122
                      +v++ + +aa +a+ e +G Pk+ i 
       EFC38378.1 346 AVPHQASHAAFHAMSEiFGWPKDRIV 371
                      78888999999999886799998886 PP

>> SpoVAD  Stage V sporulation protein AD (SpoVAD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0   3.9e-06     0.012      46     143 ..     137     241 ..     114     297 .. 0.76
   2 ?    0.5   0.0     0.065   1.9e+02     277     308 ..     380     413 ..     376     419 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 3.9e-06
                 SHHHHHHHHHHHHHHHHHHHTT--GGG-SEEEEEESSGGGH...HHHHHHHHH--.....-EEEB--GGGHHHHHHHHHHHHHHTTS-SEEEEEEEE-C CS
      SpoVAD  46 sfekaesklleeavkkalkkanlkkedidfllaGDLlnqli...sssfaarelki.....PflglygaCstsaeslalaallvdggfakrvlaatsshf 136
                   e   s +  +a+ +alk+anlk ed+d+++      q +   +s f  +el++     P l++++ C +++ ++ + a l+++g+ +++l + s   
  EFC38378.1 137 DKEITISWMGAQAALEALKNANLKVEDLDLIVNASGTPQRTipdTSCFIHKELGLgdsgkPSLSVHSTCLSFMVAFHMCAGLIESGMYEKILIV-STEI 234
                 556666778899*******************98887777653446788889887666666******************************9865.5556 PP

                 CHHHHHS CS
      SpoVAD 137 aaaekqf 143
                 +++  +f
  EFC38378.1 235 STVGLNF 241
                 6665555 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.065
                 HHHHHHHHHHHHHHHHTTS-S...EEEEEEEEE-- CS
      SpoVAD 277 gcsavvlagyllkklkkgelk...rvllvatGall 308
                 + sa++ ++ l++ ++ g++k   rvll++tGa l
  EFC38378.1 380 TISASIPMA-LYEAVQDGRIKrgdRVLLIGTGAGL 413
                 566776654.899999999984446*******966 PP

>> Thiolase_N  Thiolase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.0   1.1e-05     0.033      19     113 ..     138     233 ..     126     248 .. 0.81
   2 ?    1.1   0.1     0.067     2e+02     247     258 ..     251     262 ..     246     264 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.1e-05
                 TTS-HHHHHHHHHHHHHHHHTS-GGGCCEEEEEHSSCTTSTSCHHHHHHHHTTS-TT.SEEEEEEHGGGHHHHHHHHHHHHHHTTSHSEEEEEEEE CS
  Thiolase_N  19 kdlsaeeLlaealkallekagvdpeevdevivGnvlqagegqniarqaalkagipee.vpavtvnkvcsSglkavalaaqsiaageadvvvagGvE 113
                 k+++++ ++a+a+ ++l++a+++ e++d ++ +    +      +  ++ ++g+ ++  p+  v  +c S + a +++a+ i +g ++ ++++ +E
  EFC38378.1 138 KEITISWMGAQAALEALKNANLKVEDLDLIVNASGTPQRTIPDTSCFIHKELGLGDSgKPSLSVHSTCLSFMVAFHMCAGLIESGMYEKILIVSTE 233
                 67888999********************98865554443333344444555666554279****************************99998777 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.067
                 BEEEEEEEEEEE CS
  Thiolase_N 247 isDGaaavllms 258
                 i DGaaav+l++
  EFC38378.1 251 IGDGAAAVVLTK 262
                 78*******987 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   5.5e-05      0.16      52      92 ..     377     419 ..     369     421 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.5e-05
                 TTEEE--HHHHHHHHHHTT..--TT-EEEEES-TTSHHHHHHH CS
        PCMT  52 ynatiSaphmvalalelle..lkkgarvLevGsGsGyltavla 92 
                 +++tiSa   +al     +  +k+g+rvL +G+G+G  t +l+
  EFC38378.1 377 FGNTISASIPMALYEAVQDgrIKRGDRVLLIGTGAGLTTGLLS 419
                 578999999998764444488****************998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (422 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       937  (0.0522617); expected 358.6 (0.02)
Passed bias filter:                      736  (0.0410508); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.70u 0.37s 00:00:01.06 Elapsed: 00:00:00.52
# Mc/sec: 2423.14
//
Query:       EFC38379.1  [L=370]
Description: hypothetical protein NAEGRDRAFT_73830 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-20   74.1   0.1    2.2e-20   73.1   0.1    1.6  1  PARP             Poly(ADP-ribose) polymerase catalytic domain
    6.1e-14   52.5   4.1      3e-08   34.3   1.3    2.6  2  RicinB_lectin_2  Ricin-type beta-trefoil lectin domain-like


Domain annotation for each model (and alignments):
>> PARP  Poly(ADP-ribose) polymerase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.1   0.1   2.5e-24   2.2e-20      21     131 ..     258     363 ..     217     370 .] 0.77

  Alignments for each domain:
  == domain 1  score: 73.1 bits;  conditional E-value: 2.5e-24
                 EEEEEEEEEEEEETTHHHHCGCCGG.....SS-EEEEEEEE-GGGHHHHHHH-S--S-TTS-GGGSTTSSSEEEBSSHHHHHGGG--BSSS-EEEEEEE CS
        PARP  21 yklkileifrvqregeaerfqekkk.....lrnrrlLfHGsrltnvasilsqGLriappeapvtGymfGkGiYfAddaskSanYcktsekkgsglllLa 114
                 +++k +ei + ++  e+ +     +     ++n+++L+HG++ + v +i ++G   + ++a+++G  fG GiYfA+  skS +Yc++ +++++  +lL+
  EFC38379.1 258 IQVKTEEIPKSSTAFEWMK-----NsglnsDMNEKYLWHGTKPEYVQAITEHGS--DERVASLSG-LFGAGIYFAEYCSKSDQYCTP-DSNNEFTILLC 347
                 4444444444444444444.....4555559***********************..*******88.6*******************9.8888999**** PP

                 EEE--SEEEESS--TGC CS
        PARP 115 eValGdikeltkadyle 131
                 +V lG+ +++++ + ++
  EFC38379.1 348 RVVLGK-QTYFTPNGMT 363
                 ******.4444444443 PP

>> RicinB_lectin_2  Ricin-type beta-trefoil lectin domain-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.2   1.8e-07    0.0016      15      58 ..      11      54 ..       5      61 .. 0.85
   2 !   34.3   1.3   3.4e-12     3e-08      12      88 ..      61     138 ..      47     139 .. 0.87

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 1.8e-07
                     EEEECTSSSEEEECGCCTBCTTEEEEEE-TTT-GGCEEEEECCE CS
  RicinB_lectin_2 15 ytiknvasgkvLdvaggstanganvqqwtcsgaanqqWrledtg 58
                     +tiknv+sgk+L+++++  +nga  q w++ +    q+ l + +
       EFC38379.1 11 VTIKNVNSGKYLNISSDFSNNGAYFQLWENPSVSRSQFVLIKSS 54
                     89***************9999********999999999994333 PP

  == domain 2  score: 34.3 bits;  conditional E-value: 3.4e-12
                      TT.EEEEECTSSSEEEECGCCTBCTTEEEEEE-TTT-GGCEEEEECCESSEEEEEETTTTEEEEECGCS-STTEEEEE CS
  RicinB_lectin_2  12 dg.yytiknvasgkvLdvaggstanganvqqwtcsgaanqqWrledtgdgtyrivnkasgkvLdvaggstanGtnvqq 88 
                      ++  + ik  asgk++ +++g +++g+ + qw++ + +n qW++++ + ++++++n +s+++L v++  ++n +++ q
       EFC38379.1  61 NDlIVLIKCEASGKYVCADNGYMNEGVSIIQWDNPAWKNYQWIVKKCDHNSVSLINLNSQLYLGVKSDEKSNYSSIVQ 138
                      3425889**************************99*******************************777799888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       617  (0.0344135); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.36s 00:00:01.00 Elapsed: 00:00:00.55
# Mc/sec: 2011.76
//
Query:       EFC38380.1  [L=264]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (264 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       959  (0.0534888); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 1549.55
//
Query:       EFC38381.1  [L=1058]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.1e-09   35.8   0.3      3e-08   34.1   0.1    2.1  2  VWA           von Willebrand factor type A domain
    6.9e-07   29.9   0.1    3.2e-06   27.8   0.1    2.2  1  VWA_2         von Willebrand factor type A domain
    0.00091   19.4   0.1      0.004   17.3   0.0    2.1  2  DUF2201       VWA-like domain (DUF2201)
    0.00094   18.6   0.1     0.0018   17.7   0.1    1.4  1  VWA_CoxE      VWA domain containing CoxE-like protein
     0.0024   16.1   1.7      0.076   11.1   0.0    2.3  2  DUF2828       Domain of unknown function (DUF2828)
  ------ inclusion threshold ------
        0.1   12.6   0.1       0.28   11.3   0.1    1.7  1  HJURP_C       Holliday junction regulator protein family C-te
       0.11   11.8   1.6        0.4   10.0   0.4    2.3  2  Beta_protein  Beta protein
       0.13   12.3   2.5       0.31   11.1   0.1    2.7  2  FlxA          FlxA-like protein
        1.7    7.5  10.8       0.21   10.4   2.6    2.3  2  LMBR1         LMBR1-like membrane protein


Domain annotation for each model (and alignments):
>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.1   0.1   1.5e-11     3e-08       2     160 ..      65     219 ..      65     233 .. 0.82
   2 ?   -3.0   0.0       3.8   7.6e+03      53      97 ..     338     385 ..     313     391 .. 0.65

  Alignments for each domain:
  == domain 1  score: 34.1 bits;  conditional E-value: 1.5e-11
                 EEEEEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHGTSS CS
         VWA   2 ivfvlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssagaR 100
                 +v++lD Sgsm+++ + ++k ++++l+ +++   ++ rv ++ + ++++  ++++++s  +e l+++++  ++gggt+  ++  + a++ +  +  g  
  EFC38381.1  65 LVIALDRSGSMSGSAISEAKLALESLLTNID--GHNERVLFIPYDTSAEL-IDMSRMS-LTEKLNQVQR-VHAGGGTD-FACVFD-AIRLFTGALDG-- 154
                 79*****************************..8999*******988765.5888877.5888889999.58888888.999999.66755556666.. PP

                 TTSEEEEEEEESS--CS.SHTHHHHHHHH......GCTEEEEEEEESSSHHHHHHHHHSSSSC.HHCE CS
         VWA 101 enakkviilltdGksnd.gdpkeaaneak......eqgikvfavGvgnadekelLnkiasepg.eghv 160
                    +  i+++tdG++   g+ ++a++ +k      ++  +++++G+++ +++ lL+++   ++ +g++
  EFC38381.1 155 ---QIAIVFFTDGQDGYnGNRETAIDMMKkrltteSESFEFHTIGFSSGHDARLLTDMTRLGSaQGTF 219
                 ...999*********8856999999999999999888***********99999999995444423344 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 3.8
                 EETTSHCHH.HHHHHHHHTG..SGGGGSSC-HHHHHHHHHHHHHHHHG CS
         VWA  53 fslndyssk.eellsalnnl..kysgggttntgkalkyaleklfkssa 97 
                  sl + ++k +++ ++l+++  +++ + ++++  al +++e +f+s a
  EFC38381.1 338 TSLEEIHTKgKTIEEKLESIssDIRKNRDRSVRRALFQLIEPIFDSLA 385
                 566665544477777777776666666666677777777777666665 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.8   0.1   1.6e-09   3.2e-06       1     107 []      65     165 ..      65     165 .. 0.78

  Alignments for each domain:
  == domain 1  score: 27.8 bits;  conditional E-value: 1.6e-09
       VWA_2   1 lvfvlDtSgSmrngdygptrleaakdaveallksl..pgdrvglvtfsdgpevlipltkdkakilnalrnleakgggtnla...aaLqlarkalkkrrk 94 
                 lv+ lD SgSm+++      ++ ak a+e+ll ++  ++ rv  + +++++e++     + ++ ln ++++ a  ggt++a   +a++l + al+ +  
  EFC38381.1  65 LVIALDRSGSMSGS-----AISEAKLALESLLTNIdgHNERVLFIPYDTSAELIDMSRMSLTEKLNQVQRVHAG-GGTDFAcvfDAIRLFTGALDGQ-- 155
                 79***********9.....7***************43355*******999997655567788888889999985.6666652226666666777655.. PP

       VWA_2  95 gekrvivlitDge 107
                      iv++tDg+
  EFC38381.1 156 ---IAIVFFTDGQ 165
                 ...599*****96 PP

>> DUF2201  VWA-like domain (DUF2201)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0     2e-06     0.004       1      88 [.      65     163 ..      65     173 .. 0.74
   2 ?   -2.9   0.0       3.7   7.3e+03      59      90 ..     789     822 ..     758     827 .. 0.70

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 2e-06
     DUF2201   1 lvlavDtSgSikdkelarfaaeiadilrrl..eae.vhvvavde..evqsvqrlepaeklaelq.ltggGGTdlvpvlEava....klrPdaavv.LTD 88 
                 lv+a+D SgS++ +++++ +  ++++l ++  ++e v  +  d+  e+ ++ r++ +ekl+++q ++ gGGTd++ v++a+     +l  ++a+v +TD
  EFC38381.1  65 LVIALDRSGSMSGSAISEAKLALESLLTNIdgHNErVLFIPYDTsaELIDMSRMSLTEKLNQVQrVHAGGGTDFACVFDAIRlftgALDGQIAIVfFTD 163
                 79**************************99742333555556652245567778889999999648999*********998611113444555555666 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.7
     DUF2201  59 qltggGGTdlvpvlEavaklrPdaavv..LTDle 90 
                 + +  G T+   v E+v++++     +  LT l+
  EFC38381.1 789 STESSGTTSTETVKETVNENQDIEDYIlnLTELT 822
                 4556677777777777777766554444566665 PP

>> VWA_CoxE  VWA domain containing CoxE-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.1     9e-07    0.0018      56     168 ..      61     172 ..      34     184 .. 0.68

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 9e-07
    VWA_CoxE  56 kprelvllvDvSgSmaaysaifla..llhAllqqlp....rtevfaFdtr..lvdlTralrerDpaeaLarvsaavedlgGgTrigaalaeflelvtrp 146
                 + + lv+ +D SgSm+  sai  a   l++ll +++    r+ ++ +dt+  l+d++r     +++e L++v+  +   gGgT+ +  + ++++l+t  
  EFC38381.1  61 RGKLLVIALDRSGSMSG-SAISEAklALESLLTNIDghneRVLFIPYDTSaeLIDMSR----MSLTEKLNQVQ--RVHAGGGTDFAC-VFDAIRLFT-G 150
                 33369999*******99.7775431145788888888444555555566522445444....45666666666..4458*****975.667788888.8 PP

    VWA_CoxE 147 aLsrravvvlvsDglergdree 168
                 aL  + ++v ++Dg ++++ ++
  EFC38381.1 151 ALDGQIAIVFFTDGQDGYNGNR 172
                 99************88876654 PP

>> DUF2828  Domain of unknown function (DUF2828)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.0   3.8e-05     0.076     417     500 ..      70     145 ..      19     156 .. 0.83
   2 !    3.6   0.4     0.007        14     138     282 ..     754     907 ..     734     921 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 3.8e-05
     DUF2828 417 dvSgsmsslsfkkkttpmevaiaLsLlvaelskpPfkgkvitFseepelvkiegektLaekvekveeaewgmntdfqaVFedli 500
                 d Sgsm   s   ++   e+ +aL  l++++     +  +i ++++ el  +++  +L+ek+++v+++++g  tdf  VF d i
  EFC38381.1  70 DRSGSM---S---GSAISEAKLALESLLTNIDGHNERVLFIPYDTSAELIDMSR-MSLTEKLNQVQRVHAGGGTDFACVF-DAI 145
                 778888...3...455677778999999999888888899*************9.*************************.655 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.007
     DUF2828 138 kkekkkeekkkkkkkkkkekkkerk...........keekekkeeekeeakekrkekeaeraeklleklesdkkyraLhltvarlFaeqLkkDlelles 225
                 kkek +e  +++++++++  +   +             ++e++ ++++e+ ++  +++++ ++ +l+  e  +k   L+++ +++F ++++k l ++++
  EFC38381.1 754 KKEKYREMINNSSSQETHYGE---TirsmlgisntpVVSTESSGTTSTETVKETVNENQDIEDYILNLTELTPKAEELYTKLSEVFQKRIQKYLVKINN 849
                 333333322222222222222...13346677776655666666667777778889999999*******************************999998 PP

     DUF2828 226 akkkakk...kisLaaKWaPsless.hDkhtllaeaiaellfprelsselkeelsreeylk 282
                    ++++   +i  +aK +  ++++ h k+++  eai +  + + +ss+    ++r++yl+
  EFC38381.1 850 WMGQQNEivlDIDNSAKICLLIQTInHQKNANRREAIQRNEYISPFSSTQ---EERTNYLR 907
                 77666556778888999998877643888888888888777766655443...34444444 PP

>> HJURP_C  Holliday junction regulator protein family C-terminal repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   0.00014      0.28      14      41 ..     819     846 ..     813     856 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00014
     HJURP_C  14 feltprtenkYreIkeeFDkLhqkycls 41 
                 +eltp++e+ Y+++ e F+k +qky  +
  EFC38381.1 819 TELTPKAEELYTKLSEVFQKRIQKYLVK 846
                 789**********************866 PP

>> Beta_protein  Beta protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.34   6.8e+02     113     148 ..       6      43 ..       2      52 .. 0.67
   2 ?   10.0   0.4    0.0002       0.4      20     124 ..     809     920 ..     805     947 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.34
  Beta_protein 113 avkkqierrdkfrgvavRldqddf.sae..iteeierll 148
                   ++ +q e +++++gv++R++++++ + e  +++ i +++
    EFC38381.1   6 KMSHQEE-QTTSSGVVFRIEKQKMvQVEspLDSSIMNII 43 
                   5555655.66669******99998644434466666655 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.0002
  Beta_protein  20 ddvksrilPlfelppkketpkkklekhldka....ldrikeawkrrravflDllddadqltedgrevleellellsee.gld..iiPviqldrddsa 109
                   +d+ + il l el+pk e+  +kl++ ++k+    l +i++ ++++++++lD+ d++++++   + ++ +  + ++e+ +++  i P  ++++++++
    EFC38381.1 809 QDIEDYILNLTELTPKAEELYTKLSEVFQKRiqkyLVKINNWMGQQNEIVLDI-DNSAKICLLIQTINHQKNANRREAiQRNeyISPFSSTQEERTN 904
                   6888999999*****777777777777777755558899**************.666666555566666666666666566699************* PP

  Beta_protein 110 rlravkkqier.rdkf 124
                   +lr+++ +  + ++++
    EFC38381.1 905 YLRKIVLEHVQnKRNG 920
                   ****987655535554 PP

>> FlxA  FlxA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   0.00015      0.31      12      67 ..     305     363 ..     295     370 .. 0.89
   2 ?   -0.9   0.4      0.81   1.6e+03       8      60 ..     790     842 ..     784     856 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00015
        FlxA  12 ssgsasqiasLqkQiknlqkqLkelses...deltkeekkkqqqliqaQIqqlqaQIaq 67 
                 + +  s i++L  Qik+++  L e + +   ++++ ee  ++ ++i+++++++ + I++
  EFC38381.1 305 ERSEPSSIEKLSLQIKSIERFLIEAAGTissETTSLEEIHTKGKTIEEKLESISSDIRK 363
                 5677799***************999877777999***********************97 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.81
        FlxA   8 ssssssgsasqiasLqkQiknlqkqLkelsesdeltkeekkkqqqliqaQIqq 60 
                 + ss+++s++ +++  ++ +++++ + +l+e + + +e   k  +  q+ Iq+
  EFC38381.1 790 TESSGTTSTETVKETVNENQDIEDYILNLTELTPKAEELYTKLSEVFQKRIQK 842
                 55666666666666666667777777777766555555444666777777775 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   2.6   0.00011      0.21     199     313 ..     330     447 ..     296     471 .. 0.70
   2 ?    1.7   1.3     0.046        92     223     265 ..     801     875 ..     588     948 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00011
       LMBR1 199 deelkklyfeaaklntekeeaereledllkevkklrksisesdplrkyleeilk...kvPeeiaeklksnenk.teeslakle..kqlikalqkrerte 291
                   ++++  +++++++t+ +  e++le++ ++++k+r++  + + l + +e i +   ++++++ae +  + ++ +  +l++l   + ++++lqk+ +++
  EFC38381.1 330 AGTISSETTSLEEIHTKGKTIEEKLESISSDIRKNRDRSVRRA-LFQLIEPIFDslaNFNKVLAESMVGTLSNeKIANLNSLAyrSITKRSLQKKLDQR 427
                 5567777888899999999999*************99998888.5555555555444777777777666443335556666652234445555555555 PP

       LMBR1 292 kqwkrllekalelediiknkss 313
                 +q  +++e + + e+iikn+ +
  EFC38381.1 428 AQ--NNVELFEKAEEIIKNSVD 447
                 54..666666566999999765 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.046
       LMBR1 223 ledllkevkklrksisesdplrkyleeilkkvPeeiaeklks................................n 265
                 ++++++e + +++ i +  +l +  ee+ +k  e++++++++                                n
  EFC38381.1 801 VKETVNENQDIEDYILNLTELTPKAEELYTKLSEVFQKRIQKylvkinnwmgqqneivldidnsakiclliqtiN 875
                 111111111111111111112222222222222222222222222222222222222333333333333332221 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1058 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1406  (0.0784204); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 1.04u 0.31s 00:00:01.35 Elapsed: 00:00:00.56
# Mc/sec: 5688.67
//
Query:       EFC38382.1  [L=751]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   15.1   0.1      0.066   13.3   0.1    1.9  1  DUF2607   Protein of unknown function (DUF2607)
      0.037   14.1   0.2      0.037   14.1   0.2    2.2  3  PgaD      PgaD-like protein
       0.29   11.3   2.5        1.1    9.5   0.1    2.7  2  S1FA      DNA binding protein S1FA


Domain annotation for each model (and alignments):
>> DUF2607  Protein of unknown function (DUF2607)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   1.1e-05     0.066       5      72 ..      46     115 ..      42     127 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.1e-05
     DUF2607   5 slvklklrvvallavvLllllnvasieHqlDlnpeHHaqHhCqLFaaaqh..glakalpalPvlseeeaq 72 
                 s++++  ++v++l+++ + ++ v+++  +l  n  H + H+ +LF  +++   + ++   +P l++e+++
  EFC38382.1  46 SSMNVFCKIVTILLMIYMTIIMVLVLMDTLYSNNVHTSGHDVKLFHDNNYlnNVDESEFDVPTLEDEQIS 115
                 55556678999999999999999999999999*************98875227999******99988765 PP

>> PgaD  PgaD-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.5     9e+03      21      81 ..      56      65 ..      39      90 .. 0.49
   2 ?   14.1   0.2   6.2e-06     0.037       9      94 ..     489     569 ..     483     576 .. 0.83
   3 ?   -3.1   0.4       1.2   7.4e+03      19      53 ..     601     632 ..     587     658 .. 0.45

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.5
        PgaD 21 TllaWagwiyLfvpllvllawllglelfeaeillglfseasasevegslseletlrlYali 81
                T+l+ ++                                                  Y++i
  EFC38382.1 56 TILL-MI--------------------------------------------------YMTI 65
                3332.11..................................................1111 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 6.2e-06
        PgaD   9 lpwskrlldsilTlla.WagwiyLfvpllvllawllglelfeaeillglfseasasevegslseletlrlYalilvviavlLilWak 94 
                   +s+r++++++ + +  +g+ y f pl++       ++  +++i l + ++a +s ++++ls++  l++Y +i +++++++il a 
  EFC38382.1 489 DDKSSRFVKTLISIAMdTIGFDYVFIPLVIK------WNQTYQKIKLYTKQNADLSRKKTYLSSIIMLIFYYTITIGCGLVIILSAI 569
                 55567888888887762579*******9999......57788888888999*****************************9998665 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.2
        PgaD  19 ilTllaWagwiyLfvpllvllawllglelfeaeil 53 
                 i+Tl+++++   L  + l        +  ++++ l
  EFC38382.1 601 IITLMGFFVLSVLIQRKLKQ---ASDVSFVSTNYL 632
                 33333333333333332222...222333333333 PP

>> S1FA  DNA binding protein S1FA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.3      0.16   9.4e+02      12      30 ..     426     445 ..     417     455 .. 0.69
   2 ?    9.5   0.1   0.00018       1.1      10      40 ..     587     619 ..     581     625 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.16
        S1FA  12 ivllvvggllllf.lvgnyv 30 
                 ivl +v +++l++ lv ++v
  EFC38382.1 426 IVLFIVITFVLVLpLVRDFV 445
                 77777777766643776665 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00018
        S1FA  10 Gliv..llvvggllllflvgnyvlyvyaqktlP 40 
                 Gliv  l+++++ +++ l+g +vl v  q++l 
  EFC38382.1 587 GLIVmiLVLIATPIIITLMGFFVLSVLIQRKLK 619
                 67762256789******************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (751 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1412  (0.0787551); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.85u 0.31s 00:00:01.15 Elapsed: 00:00:00.54
# Mc/sec: 4215.67
//
Query:       EFC38383.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.41   10.5   1.8       0.91    9.4   1.8    1.6  1  Pedibin   Pedibin/Hym-346 family


Domain annotation for each model (and alignments):
>> Pedibin  Pedibin/Hym-346 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   1.8   5.1e-05      0.91      24      32 ..       2      10 ..       1      12 [. 0.92

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 5.1e-05
     Pedibin 24 EqKekeLkn 32
                EqK+keL+n
  EFC38383.1  2 EQKCKELSN 10
                ********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       730  (0.0407162); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2045.13
//
Query:       EFC38384.1  [L=746]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   12.8  15.6       0.94   10.0   0.9    5.8  7  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.1     0.018   3.3e+02      22      40 ..      59      77 ..      51      90 .. 0.57
   2 ?    2.6   0.1     0.011   1.9e+02       1      37 [.      60      97 ..      60     107 .. 0.79
   3 ?    1.1   0.2     0.033     6e+02      18      30 ..     111     123 ..      98     133 .. 0.61
   4 ?    5.9   2.6     0.001        19       2      30 ..     117     148 ..     111     156 .. 0.69
   5 ?   10.0   0.9   5.3e-05      0.94       1      33 [.     141     173 ..     141     188 .. 0.84
   6 ?    3.6   0.0    0.0053        95       2      42 ..     188     228 ..     187     239 .. 0.75
   7 ?   -3.5   0.0      0.91   1.6e+04      18      28 ..     357     366 ..     351     368 .. 0.55

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.018
                -TT--EEE-.-S-----GG CS
       LRR_4 22 lpnLkeLdLsgNnlitdld 40
                 p+L++L++ g   ++ ++
  EFC38384.1 59 TPQLEKLYIEGSISVKYIS 77
                6777777775542222222 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.011
                SS--EEE--.SS---E-S-HHH-TT--EEE.-.-S---- CS
       LRR_4  1 pnLevLdLs.nNqltdiplleklpnLkeLd.LsgNnlit 37
                p+Le+L++  +  ++ i+++++ + Lk++  + +N +i+
  EFC38384.1 60 PQLEKLYIEgSISVKYISNINNWKELKTFKtC-FNDYIW 97
                68999999966788899999989999998854.776665 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.033
                 -HHH-TT--EEE- CS
       LRR_4  18 lleklpnLkeLdL 30 
                 +l+k+ nL++L  
  EFC38384.1 111 SLSKCNNLTSLAF 123
                 3556777777755 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.001
                 S--EEE--SS---E-S-...HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdL 30 
                 nL++L + n  ++++++   ++klpnL+eL L
  EFC38384.1 117 NLTSLAFENEDISSWEFkelFNKLPNLTELQL 148
                 44444445325777777777779*******88 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 5.3e-05
                 SS--EEE--SS---.E-S-HH...H-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqlt.diplle...klpnLkeLdLsgN 33 
                 pnL++L L +  +  d++ ++   +++nLk L++  N
  EFC38384.1 141 PNLTELQLVQ--IEtDLSMFQtigSFTNLKNLSC--N 173
                 8********9..9999999888857*********..3 PP

  == domain 6  score: 3.6 bits;  conditional E-value: 0.0053
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----GGGG CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdldeL 42 
                 +Le L ++   +td +  +   lp  keL + g + +td+  L
  EFC38384.1 188 KLERLQIAE--VTDSNVsFICeLPRIKELEILGSPELTDVGAL 228
                 677777887..88544454433999999999899999998765 PP

  == domain 7  score: -3.5 bits;  conditional E-value: 0.91
                 -HHH-TT--EE CS
       LRR_4  18 lleklpnLkeL 28 
                 ++e l+ L++L
  EFC38384.1 357 FPE-LTFLEHL 366
                 344.5555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (746 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.45
# Mc/sec: 4996.21
//
Query:       EFC38385.1  [L=448]
Description: beta-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.5e-72  241.7   0.1    3.2e-71  239.6   0.0    1.9  2  Tubulin          Tubulin/FtsZ family, GTPase domain
    1.9e-36  125.0   0.1    2.9e-36  124.4   0.1    1.3  1  Tubulin_C        Tubulin C-terminal domain
    3.1e-07   30.7   0.0    6.4e-07   29.7   0.0    1.5  1  Misat_Tub_SegII  Misato Segment II tubulin-like domain
  ------ inclusion threshold ------
       0.14   12.1   0.6       0.29   11.1   0.6    1.5  1  cEGF             Complement Clr-like EGF-like


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  239.6   0.0   7.1e-75   3.2e-71       1     196 [.       3     211 ..       3     212 .. 0.99
   2 ?   -0.7   0.0       0.3   1.3e+03      61     111 ..     286     332 ..     273     341 .. 0.74

  Alignments for each domain:
  == domain 1  score: 239.6 bits;  conditional E-value: 7.1e-75
                 EEEEEEEHHHHHHHHHHHHH...HHHCH..............HHHT.....TTEEEEE....EEESBHHHHHTS-GS........EEEE--CCCCTTC- CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiqsdg..........dslesfFsesgkveyiprsvaidtdpqvlneikags..elfnpnklllgkegagnng 87 
                 ei+ i vGqcGnqig+++we++ +ehg++ dg          ++l ++Fses+ ++y+prsv++d++++vl+ +k+++  +lf+p++++ ++ +agnn+
  EFC38385.1   3 EIVSISVGQCGNQIGQHFWETIRNEHGLNADGefvetnpilkENLGVYFSESQGNRYVPRSVLVDLESSVLDTVKSSKsgTLFRPDNFIASEGSAGNNW 101
                 79***************************9999****************************************************************** PP

                 -TT-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--.GG.G-HHHHHHHHHHHHHHHHT-SEEE CS
     Tubulin  88 aggypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs.efsevvvepynailalkelieesdavi 185
                 a+g+++ g+e+a++i++ +rkeve+c++lqgf++t+slgGGTGSGlg+++l++lke++p++++ +++vlPs ++se vvepyna l+l++lie++d v+
  EFC38385.1 102 AKGHYTEGAELADQIMDVLRKEVEHCECLQGFQLTHSLGGGTGSGLGTLLLSKLKEDFPDRMLAAFSVLPSpKMSETVVEPYNATLSLHQLIESADEVF 200
                 *************************************************************************************************** PP

                 EEEHHHHHCCS CS
     Tubulin 186 vidNdaLlkil 196
                 ++dN+aL++i+
  EFC38385.1 201 CLDNEALFDIC 211
                 **********9 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.3
                 HHTS-GS......EEEE--CCCCTTC--TT-HHHHHHHHHHTHHHHHHHHT CS
     Tubulin  61 lneikagselfnpnklllgkegagnngaggypevgkeaaeeileeirkeve 111
                 ++e+++  ++fn+++++   + + +++  +  +   +  + + +ei++++ 
  EFC38385.1 286 IAELTS--QMFNKKNMMAACDPSMGKYLAASATF--RGLNLSTNEIDEQML 332
                 444444..59999999999999999998888885..667777778877765 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  124.4   0.1   6.4e-40   2.9e-36       1     124 [.     261     382 ..     261     384 .. 0.98

  Alignments for each domain:
  == domain 1  score: 124.4 bits;  conditional E-value: 6.4e-40
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEE.SSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEECEC CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirG.dvepkevnkavqrikekkkaqfveWiptgikvalnkksp 98 
                 PrlhF++++ aPl + ++++++ +s++++t++++++kn+m+++dp+ gkyla+++++rG + +++e+++++  ++ k + +fveWip++ik ++++++p
  EFC38385.1 261 PRLHFFVVGSAPLAATSSQQYSALSIAELTSQMFNKKNMMAACDPSMGKYLAASATFRGlNLSTNEIDEQMLGMQRKYSQNFVEWIPNNIKSSVCDVPP 359
                 9************************************************************************************************** PP

                 T-TTTSSCEEEEEEEEGGGHHHHHHH CS
   Tubulin_C  99 yvkkqskvsvlmlaNttsiaelfkrl 124
                 +++k s   +++++N+t+i+e+fkr+
  EFC38385.1 360 VGQKVS---GTFIGNSTAIQEVFKRI 382
                 *99877...***************98 PP

>> Misat_Tub_SegII  Misato Segment II tubulin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.0   1.4e-10   6.4e-07       1      79 [.       2      82 ..       2     115 .. 0.74

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 1.4e-10
  Misat_Tub_SegII  1 rEivtlqlGnyaNyvgtHfWNtQesyftydeeeeesevdhdvlfreget....kqgqvtytPRllivDlkgslgslrkegely 79
                     rEiv++++G+  N +g HfW t  +    + + e   v+++   +e+ +    +++   y+PR ++vDl++s+  + k++++ 
       EFC38385.1  2 REIVSISVGQCGNQIGQHFWETIRNEHGLNADGE--FVETNPILKENLGvyfsESQGNRYVPRSVLVDLESSVLDTVKSSKSG 82
                     8********************9777554444433..56666666666655564678899***********9988877766654 PP

>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.6   6.4e-05      0.29       3      13 ..     126     136 ..     126     145 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 6.4e-05
                 EEE-STTEEE. CS
        cEGF   3 rCsCppGYklt 13 
                 +C+C +G++lt
  EFC38385.1 126 HCECLQGFQLT 136
                 8********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (448 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.26s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 3132.34
//
Query:       EFC38386.1  [L=1104]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.5   0.0       0.27   11.4   0.0    1.5  1  Fn3-like  Fibronectin type III-like domain


Domain annotation for each model (and alignments):
>> Fn3-like  Fibronectin type III-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   1.5e-05      0.27      26      59 ..     579     611 ..     578     616 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 1.5e-05
                 EEEE-TT-EEEEEEEEEC.GGG-EEETTTTEEE-- CS
    Fn3-like  26 kveLapGesktvtftldr.kdlsvwdeekqkwvve 59 
                  veL  Ges+t+tf++++ +d s++ ++  +w +e
  EFC38386.1 579 EVELDVGESQTITFDISVsRDASFFVDK--CWKLE 611
                 599**************86888888777..78765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1104 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.88u 0.36s 00:00:01.24 Elapsed: 00:00:00.55
# Mc/sec: 6004.49
//
Query:       EFC38387.1  [L=816]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (816 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1923  (0.107256); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 4646.16
//
Query:       EFC38388.1  [L=605]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.9e-05   24.2   9.6    0.00011   22.4   9.6    2.0  1  zf-4CXXC_R1    Zinc-finger domain of monoamine-oxidase A repr


Domain annotation for each model (and alignments):
>> zf-4CXXC_R1  Zinc-finger domain of monoamine-oxidase A repressor R1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   9.6   5.9e-09   0.00011       8      79 ..     318     412 ..     312     423 .. 0.78

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 5.9e-09
  zf-4CXXC_R1   8 tChqCrqktletktsCkakeCk........................saklkfCekClknRygeeveevaakkeWvCPkCrgiCncslcrkkkglap 79 
                   Ch+Cr k+ ++   C  ++ +                           ++ C++C++++   + ++   +  WvC +Cr  C++ lc kk+g++ 
   EFC38388.1 318 YCHFCRTKQGCRM-ICDISKISnkrefyekhniskpdpnfqftqrlPCMVTTCKDCFEKKELGDFDHYLYNGGWVCTHCRYSCDSPLCTKKSGISL 412
                  6*****9987765.5655433344555555556666666666665556699****************************************99765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (605 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2540  (0.14167); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                        33  (0.00184059); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.98u 0.35s 00:00:01.33 Elapsed: 00:00:00.50
# Mc/sec: 3606.01
//
Query:       EFC38389.1  [L=803]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.025   14.7   0.4       0.11   12.7   0.4    2.2  1  EZH2_WD-Binding  WD repeat binding protein EZH2
      0.053   13.9   5.5      0.073   13.5   1.5    2.9  3  HycH             Formate hydrogenlyase maturation protein Hyc
       0.07   12.7   6.0        4.1    6.9   0.2    4.0  4  DUF1281          Protein of unknown function (DUF1281)
        2.7    7.6   7.2        7.1    6.3   4.9    2.6  2  FAM176           FAM176 family


Domain annotation for each model (and alignments):
>> EZH2_WD-Binding  WD repeat binding protein EZH2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.4   2.3e-05      0.11       6      21 ..     585     600 ..     584     600 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2.3e-05
  EZH2_WD-Binding   6 sNrqKiqekteiLNee 21 
                       N +Kiq +t++LN+e
       EFC38389.1 585 VNIRKIQFRTNLLNTE 600
                      699***********98 PP

>> HycH  Formate hydrogenlyase maturation protein HycH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   1.5   1.6e-05     0.073      50     127 ..     171     246 ..     162     248 .. 0.80
   2 ?    0.2   0.0       0.2   9.1e+02      65      97 ..     394     425 ..     385     460 .. 0.70
   3 ?   -2.6   0.0       1.5   6.7e+03      51      65 ..     481     495 ..     477     498 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.6e-05
        HycH  50 leeyeklvalleegearrKlegllkfgEiei.dkehvellaaaldellkelesekeewskellelLeeiekepaiylmv 127
                  e+++++ + le+g++++Kle ++k  Eie+ + +h+ ++++++++ +   e++k+++ +++le+L++ +++ +i  ++
  EFC38389.1 171 DETFTNWNDYLENGKTNEKLETVKK-SEIELlQLTHCIIMMEEIEKKK--VENNKQKMVRSVLEYLKKEKRDDCINFVK 246
                 589*******************988.7888625678888877777644..46667889*********999999997766 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.2
        HycH  65 arrKlegllkfgEieidkehvellaaaldellk 97 
                  ++K   + ++gE e++k+h +++   +++ ++
  EFC38389.1 394 CKNKKIDISEWGEDELNKSHPNVIK-RFKNQKE 425
                 567778899**********987664.3444444 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.5
        HycH  51 eeyeklvalleegea 65 
                 ++y+k+v+ +e++e 
  EFC38389.1 481 DVYKKWVKNFEQEEE 495
                 68********99874 PP

>> DUF1281  Protein of unknown function (DUF1281)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0     0.047   2.1e+02     104     133 ..      73     102 ..      67     122 .. 0.84
   2 ?    2.7   0.4     0.018        82      51     161 ..     173     289 ..     166     298 .. 0.66
   3 ?    6.9   0.2    0.0009       4.1      57     122 ..     433     499 ..     424     514 .. 0.88
   4 ?    0.7   0.0     0.074   3.3e+02      48      78 ..     763     793 ..     744     800 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.047
     DUF1281 104 rksaDWlglvtledesdvetlWeklkelle 133
                 + ++DW   v+ e + ++ t+W++ ++ ++
  EFC38389.1  73 ELYVDWKKHVKKECKNKTSTAWKESEKSRK 102
                 5689******************99887665 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.018
     DUF1281  51 AFeqWlelL...kedveLteeaieeierlye...qsglaavkWeslteakrealaall....erksaDWlglvtledesdvetlWeklkelleeavPld 139
                  F++W + L   k++ +L++ + +eie l        +++++ +++ + k++++ ++l    ++k+ D +++v+    +   +  ++ ++ +++ + + 
  EFC38389.1 173 TFTNWNDYLengKTNEKLETVKKSEIELLQLthcIIMMEEIEKKKVENNKQKMVRSVLeylkKEKRDDCINFVK----KYCIYSMDDTSKHQSRLLICL 267
                 79999888822245778888888888766552232334555556666666666655552221567777788777....444555566777777888888 PP

     DUF1281 140 lllllptrLaaEinGfnggllk 161
                 +  +l   L+ E+n  + +ll+
  EFC38389.1 268 FHFILGKLLKMEVNNKEMRLLN 289
                 9999999999999986666665 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0009
     DUF1281  57 elLkedveLteeaieeierlyeqsgla.avkWeslteakrealaallerksaDWlglvtledesdve 122
                 + L e+ +L+e+ + +i+++y ++  + +++ e+  ++k+++  ++  + +  W+  ++ e+e d +
  EFC38389.1 433 HFLDEGLKLDESLVLNIDNIYMDEAYKiYMNLEEKNTTKKARTNSIYPDVYKKWVKNFEQEEEEDSD 499
                 679999****************99887478999**************************99998876 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.074
     DUF1281  48 enlAFeqWlelLkedveLteeaieeierlye 78 
                 +n  Fe+ l+l +e+  ++e+++ +ie++++
  EFC38389.1 763 KNETFEEKLKLYREKFGVDESNCPSIEEIHT 793
                 7999**********************99876 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.17   7.8e+02      31      68 ..      61      99 ..      53     103 .. 0.77
   2 ?    6.3   4.9    0.0016       7.1      63     102 ..     492     531 ..     462     544 .. 0.44

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.17
      FAM176 31 cvG.LlltLcllviriscrkdlerlkkkkkklkeeseka 68
                c+G L l + ll + + ++k+++++ k+k++++ +++++
  EFC38389.1 61 CFGsLELPIQLLELYVDWKKHVKKECKNKTSTAWKESEK 99
                888566999999999*******98888888777665544 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0016
      FAM176  63 eesekasededeeeeeeeedsseseaeeelsefertlsvn 102
                 +e+e++s++e++ ++eee+ +s+++ ++   +++++ +++
  EFC38389.1 492 QEEEEDSDEEEDSSDEEEKVESKKRKSTPKLRIKKKTKIE 531
                 1111111111222222222222222222222333333444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (803 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2373  (0.132355); expected 358.6 (0.02)
Passed bias filter:                      604  (0.0336884); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.77u 0.30s 00:00:01.07 Elapsed: 00:00:00.46
# Mc/sec: 5217.80
//
Query:       EFC38390.1  [L=2122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-12   47.2 155.5    2.5e-05   24.5   6.6   12.8 13  EGF_2     EGF-like domain
     0.0019   18.5   3.8     0.0019   18.5   3.8    9.9  9  EGF       EGF-like domain
  ------ inclusion threshold ------
      0.017   15.0   0.6       0.93    9.4   0.1    2.9  2  BpuSI_N   BpuSI N-terminal domain
        0.1   13.2   0.0        0.1   13.2   0.0    2.7  3  ANAPC1    Anaphase-promoting complex subunit 1
        7.4    6.7   9.6        5.4    7.2   0.7    4.0  4  DUF3244   Domain of unknown function (DUF3244)


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   1.1     0.094   3.4e+02      22      32 .]     595     605 ..     595     605 .. 0.94
   2 !    6.8   8.8    0.0025         9       6      28 ..     619     640 ..     615     647 .. 0.85
   3 ?   -1.3   0.1      0.83     3e+03      11      22 ..     644     654 ..     641     661 .. 0.79
   4 !   16.0  12.0   3.3e-06     0.012       5      32 .]     661     687 ..     653     687 .. 0.86
   5 !   16.8   8.1   1.8e-06    0.0063       7      32 .]     703     727 ..     698     727 .. 0.87
   6 !   24.5   6.6   6.9e-09   2.5e-05       6      32 .]     741     766 ..     736     766 .. 0.87
   7 !   13.8   9.1   1.6e-05     0.056       7      32 .]     781     805 ..     777     805 .. 0.90
   8 !   11.0   4.4   0.00012      0.42       6      32 .]     819     845 ..     816     845 .. 0.90
   9 ?    4.0   1.5     0.019        67      23      32 .]     848     857 ..     846     857 .. 0.96
  10 !    9.8   3.5   0.00028         1       7      32 .]     872     897 ..     867     897 .. 0.81
  11 ?    1.7   1.2     0.096   3.5e+02      22      32 .]     899     909 ..     899     909 .. 0.95
  12 !   10.6  10.1   0.00016      0.59       4      32 .]     920     948 ..     914     948 .. 0.83
  13 ?   -4.7   4.3         5   1.8e+04      23      32 .]     951     960 ..     950     972 .. 0.48

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.094
       EGF_2  22 dCdsgyqGktC 32 
                 +C sgy+G++C
  EFC38390.1 595 SCASGYTGASC 605
                 5********** PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0025
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyq 28 
                 + C+g G+C  ++  C+C+++ +
  EFC38390.1 619 NVCNGKGKCTGPN-TCSCSASIS 640
                 68********888.9***99876 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.83
       EGF_2  11 hGtCvnqcGqCd 22 
                  GtCv + G C+
  EFC38390.1 644 SGTCV-PYGFCE 654
                 69999.778774 PP

  == domain 4  score: 16.0 bits;  conditional E-value: 3.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g+GtC  ++  C Cd++y+G+ C
  EFC38390.1 661 SGSCHGRGTCF-FNSTCACDRSYYGDAC 687
                 567*******6.5778************ PP

  == domain 5  score: 16.8 bits;  conditional E-value: 1.8e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C++hG+C +    C+C++gy Gk+C
  EFC38390.1 703 VCSNHGKCTDID-LCECSTGYAGKNC 727
                 7*******7445.8************ PP

  == domain 6  score: 24.5 bits;  conditional E-value: 6.9e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+GtCv + G C+C++gy+G  C
  EFC38390.1 741 DVCSGQGTCV-KPGICSCKTGYYGSMC 766
                 68*******9.456**********999 PP

  == domain 7  score: 13.8 bits;  conditional E-value: 1.6e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+  GtCv+ + +C C +gy+G +C
  EFC38390.1 781 VCSSKGTCVDYN-NCNCTDGYFGENC 805
                 5*******9666.8************ PP

  == domain 8  score: 11.0 bits;  conditional E-value: 0.00012
       EGF_2   6 eiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 + C+g+G+C ++   C+C  ++  G +C
  EFC38390.1 819 NVCNGNGICTALD-TCSCtRPKSIGSNC 845
                 67*******9999.9***9999999999 PP

  == domain 9  score: 4.0 bits;  conditional E-value: 0.019
       EGF_2  23 CdsgyqGktC 32 
                 C++gy+G +C
  EFC38390.1 848 CEDGYYGTHC 857
                 ********** PP

  == domain 10  score: 9.8 bits;  conditional E-value: 0.00028
       EGF_2   7 iCgghGtCvnqcGqCdC.dsgyqGktC 32 
                  C+ +G+C + +  C+C +    G+tC
  EFC38390.1 872 VCSARGHCKSVN-ICVCeSETIKGDTC 897
                 6*******9666.9***6666669999 PP

  == domain 11  score: 1.7 bits;  conditional E-value: 0.096
       EGF_2  22 dCdsgyqGktC 32 
                 dC +gy+G +C
  EFC38390.1 899 DCITGYYGSKC 909
                 6********** PP

  == domain 12  score: 10.6 bits;  conditional E-value: 0.00016
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s ++ C+ +GtC +  ++C+C++   G +C
  EFC38390.1 920 SeESVCNYRGTCTS-YNVCKCNTRSNGTYC 948
                 25789*******84.459************ PP

  == domain 13  score: -4.7 bits;  conditional E-value: 5
       EGF_2  23 CdsgyqGktC 32 
                 C + y+G +C
  EFC38390.1 951 CLDYYTGQSC 960
                 4455555554 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.37   1.3e+03      24      31 ..     596     603 ..     593     604 .. 0.90
   2 ?   -2.6   6.0       2.1   7.4e+03       4      24 ..     617     635 ..     614     637 .. 0.71
   3 !    5.7   5.1    0.0051        18       4      31 ..     659     685 ..     653     686 .. 0.85
   4 !   18.5   3.8   5.2e-07    0.0019       3      32 .]     700     726 ..     699     726 .. 0.91
   5 !   14.8   4.5   7.6e-06     0.027       5      30 ..     741     763 ..     737     764 .. 0.88
   6 !   12.5   4.7   3.9e-05      0.14       3      32 .]     777     804 ..     775     804 .. 0.92
   7 ?   -2.7   9.4       2.1   7.7e+03       3      25 ..     818     836 ..     816     856 .. 0.84
   8 ?   -0.5   1.4      0.46   1.7e+03       4      25 ..     869     888 ..     867     896 .. 0.80
   9 ?   -7.0   9.3         5   1.8e+04       6      26 ..     925     941 ..     914     957 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.37
                 ECTTEEST CS
         EGF  24 CpeGytGk 31 
                 C++GytG+
  EFC38390.1 596 CASGYTGA 603
                 ******96 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.1
                 TT..STTT-EEEEETTTEEEEEE CS
         EGF   4 np..CsngGtCvdtgrggytCiC 24 
                 np  C++ G+C +++    tC C
  EFC38390.1 617 NPnvCNGKGKC-TGP---NTCSC 635
                 5666*******.555...45555 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0051
                 TT...STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np...CsngGtCvdtgrggytCiCpeGytGk 31 
                 ++   C+++GtC+ ++    tC C+  y G+
  EFC38390.1 659 YNsgsCHGRGTCFFNS----TCACDRSYYGD 685
                 55667***********....****9999885 PP

  == domain 4  score: 18.5 bits;  conditional E-value: 5.2e-07
                 STT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   3 pnp.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 ++  Csn+G+C d       C+C++Gy+Gk+
  EFC38390.1 700 SYGvCSNHGKCTDID----LCECSTGYAGKN 726
                 5667***********....**********97 PP

  == domain 5  score: 14.8 bits;  conditional E-value: 7.6e-06
                 T.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytG 30 
                   Cs++GtCv +g    +C C++Gy G
  EFC38390.1 741 DvCSGQGTCVKPG----ICSCKTGYYG 763
                 35***********....********99 PP

  == domain 6  score: 12.5 bits;  conditional E-value: 3.9e-05
                 STT..STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   3 pnp..CsngGtCvdtgrggytCiCpeGytGkr 32 
                 ++p  Cs  GtCvd+     +C C+ Gy+G++
  EFC38390.1 777 SQPrvCSSKGTCVDYN----NCNCTDGYFGEN 804
                 57889***********....**********96 PP

  == domain 7  score: -2.7 bits;  conditional E-value: 2.1
                 STTSTTT-EEEEETTTEEEEEEC CS
         EGF   3 pnpCsngGtCvdtgrggytCiCp 25 
                 pn C+++G+C  +     tC C+
  EFC38390.1 818 PNVCNGNGICTALD----TCSCT 836
                 456*******7777....99996 PP

  == domain 8  score: -0.5 bits;  conditional E-value: 0.46
                 TT..STTT-EEEEETTTEEEEEEC CS
         EGF   4 np..CsngGtCvdtgrggytCiCp 25 
                  p  Cs +G C ++     +C C 
  EFC38390.1 869 SPavCSARGHCKSVN----ICVCE 888
                 4667*******8888....88886 PP

  == domain 9  score: -7.0 bits;  conditional E-value: 5
                 STTT-EEEEETTTEEEEEECT CS
         EGF   6 CsngGtCvdtgrggytCiCpe 26 
                 C+ +GtC ++      C+C +
  EFC38390.1 925 CNYRGTCTSYN----VCKCNT 941
                 99999996665....577754 PP

>> BpuSI_N  BpuSI N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1   0.00026      0.93      52     101 ..    1034    1083 ..    1027    1092 .. 0.81
   2 ?    2.4   0.1     0.037   1.3e+02      99     145 ..    1693    1739 ..    1678    1757 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00026
     BpuSI_N   52 rrkssnry..llvvevkrtkddvystryqlqaksyvesnqalysptekkyfi 101 
                  + kss  y  l+ v   r ++d++s ry +  k+yv    a++sp e+  f 
  EFC38390.1 1034 VTKSSTSYpmLCYVTENRLNSDLHSYRYTI--KAYVSQSDAIFSPREPIMFN 1083
                  34555555338889999********99987..56*************98886 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.037
     BpuSI_N   99 yfiisnleklilfainadkpsveqrlknGleeigdfardmsemhkqq 145 
                    +is++ k+i +a+na   s+ ++l   l + +  + dms+  +q 
  EFC38390.1 1693 NSVISEISKIIPLALNATATSLSTQLDTNLAQNSVTSEDMSNYMNQV 1739
                  5689**************************99999999999876664 PP

>> ANAPC1  Anaphase-promoting complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.6       4.2   1.5e+04      60      72 ..    1691    1703 ..    1653    1749 .. 0.44
   2 ?   -4.0   0.4         5   1.8e+04      73      95 ..    1839    1860 ..    1822    1881 .. 0.50
   3 ?   13.2   0.0   2.8e-05       0.1      30      95 ..    2030    2091 ..    2011    2107 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.2
      ANAPC1   60 ppnsfldssspll 72  
                   +ns+++  s+++
  EFC38390.1 1691 QNNSVISEISKII 1703
                  2333332222222 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 5
      ANAPC1   73 tsssqtssqkttfstesrgspkr 95  
                  ts s  +s++++fs+ s +s  +
  EFC38390.1 1839 TSISALNSNSFSFSN-SNSSLVS 1860
                  333333333333332.2222223 PP

  == domain 3  score: 13.2 bits;  conditional E-value: 2.8e-05
      ANAPC1   30 svfplpkGlllqRkpe.edqapprslrnpsappnsfldsssplltsssqtssqkttfstesrgspkr 95  
                   ++p+  G+++ R+ + +d+a + ++++p+ p+ + + +ss       q++s++++f +e r s+++
  EFC38390.1 2030 IAIPITVGCIIVREKRkRDNAKETNKEAPPNPQYERVVTSST-----LQSNSSQNAFRFEHRDSTTP 2091
                  3556666*********99999999999999999888855555.....35566666666666555544 PP

>> DUF3244  Domain of unknown function (DUF3244)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       4.5   1.6e+04      45      85 ..      72     111 ..      62     113 .. 0.72
   2 ?    7.2   0.7    0.0015       5.4      12      94 ..     366     447 ..     359     452 .. 0.85
   3 ?   -2.5   0.1       1.6   5.6e+03      36      67 ..    1537    1570 ..    1533    1580 .. 0.62
   4 ?    2.7   0.4     0.036   1.3e+02      42      79 ..    1675    1711 ..    1671    1714 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 4.5
                 EEEEEEETTT--EEEEEEE-GGGTTEEEEE-TTS-SEEEEE CS
     DUF3244  45 vtitikdeetgevvyestivnasgstisidlsgeesgeYkl 85 
                 +++ ikd+  g  ++ ++i+   +s+  i l+g+  ++Y +
  EFC38390.1  72 LEVNIKDDCGGAQLEGESITFL-NSKADILLTGYFVAQYPV 111
                 6788888866666666666655.788888888888888866 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0015
                 -.----------SEEEEEETTEEEEEESS--SEEEEEEEETTT--EEEEEEE-GGGTTEEEEE-TTS-SEEEEEEEEESS-EE CS
     DUF3244  12 teekdaRSipeiPitasiegnilsiefesplsdvtitikdeetgevvyestivnasgstisidlsgeesgeYkleltskggyl 94 
                 t +++++S+ +     ++eg+i+ +++ s+  d+t +   ++   +v ++++v +++  i+i lsg++++   l ++s+g+yl
  EFC38390.1 366 TMQAQSKSVYQF-RFRHLEGKIIQVQQLSTEYDITDSFIVSTSSPIVNSNNYVGEQKPIIYIRLSGTSKELKALSFSSNGYYL 447
                 447888888543.44567****************8887777789**************************9999999998887 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 1.6
                  EEESS--SEEE..EEEEETTT--EEEEEEE-GGG CS
     DUF3244   36 iefesplsdvt..itikdeetgevvyestivnas 67  
                  +  +s+++dvt  +t++d+  +++  +++++++s
  EFC38390.1 1537 LMGTSDVTDVTvpVTVQDSLSDQIKLKDCTITPS 1570
                  5556677777611577777777777777776665 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.036
                  -SEEEEEEEETTT--EEEEEEE-GGGTTEEEEE-TTS- CS
     DUF3244   42 lsdvtitikdeetgevvyestivnasgstisidlsgee 79  
                   +d+ i+i ++  g+v+++++++++ ++ i + l+ ++
  EFC38390.1 1675 SNDLVISIVSN-IGTVAQNNSVISEISKIIPLALNATA 1711
                  67999****99.9*****************99999776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1017  (0.0567237); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.03u 0.32s 00:00:01.35 Elapsed: 00:00:00.51
# Mc/sec: 12440.46
//
Query:       EFC38391.1  [L=310]
Description: Hypothetical protein NAEGRDRAFT_73857 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.023   14.6   0.0      0.049   13.5   0.0    1.5  1  F-box-like  F-box-like
      0.035   14.0   0.0      0.078   12.9   0.0    1.6  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   5.4e-06     0.049       2      45 ..      50      95 ..      49      97 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.4e-06
  F-box-like  2 srLPdEiLlqIFsyLppsdLlrla..lVCrrWrrvaldtplLWrrl 45
                ++LPdE +  I+s+L+  ++l+l   l  ++W  +++++ + Wr l
  EFC38391.1 50 NNLPDEMIGMILSFLDRFEILSLGnlLFFKKWSKFIFHHDEYWRAL 95
                68*************9888999755599999999999999999976 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   8.7e-06     0.078       3      26 ..      49      72 ..      47      73 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 8.7e-06
                HHHS-HHHHHHHHHTS-HHHHHHH CS
       F-box  3 lsrLPsevlrhILerLplsdllal 26
                l +LP+e +  IL++L+  ++l+l
  EFC38391.1 49 LNNLPDEMIGMILSFLDRFEILSL 72
                789******************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       801  (0.0446762); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1907.04
//
Query:       EFC38392.1  [L=575]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (575 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2516  (0.140331); expected 358.6 (0.02)
Passed bias filter:                      313  (0.0174578); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.74u 0.29s 00:00:01.03 Elapsed: 00:00:00.49
# Mc/sec: 3509.31
//
Query:       EFC38393.1  [L=210]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      5e-18   64.7   1.4      5e-18   64.7   1.4    1.8  2  Homeobox_KN  Homeobox KN domain
    7.6e-08   32.1   0.6    1.8e-07   30.9   0.6    1.6  1  Homeodomain  Homeodomain
  ------ inclusion threshold ------
        7.2    6.3   9.3         13    5.4   9.3    1.4  1  FAM176       FAM176 family


Domain annotation for each model (and alignments):
>> Homeobox_KN  Homeobox KN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1      0.91   5.4e+03      12      23 ..       2      13 ..       2      17 .. 0.80
   2 !   64.7   1.4   8.3e-22     5e-18       1      40 []      20      59 ..      20      59 .. 1.00

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.91
  Homeobox_KN 12 seedKeeLlkeT 23
                 se++K++L ke+
   EFC38393.1  2 SEAQKRTLPKEA 13
                 688999998775 PP

  == domain 2  score: 64.7 bits;  conditional E-value: 8.3e-22
  Homeobox_KN  1 WflahlhnPYPseedKeeLlkeTglsvkqitnWFINaRrR 40
                 W+++hl +PYPs+++K++L  +T l +k i+nWFINaRrR
   EFC38393.1 20 WLYDHLFHPYPSDAQKNQLSNQTSLEMKSINNWFINARRR 59
                 ***************************************9 PP

>> Homeodomain  Homeodomain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   0.6     3e-11   1.8e-07       6      54 ..       8      59 ..       4      61 .. 0.80

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 3e-11
                 SS-HHHHHHHHH.HHHH..SSS-SHHHHHHHHHHHTS-HHHHHHHHHHHHHH CS
  Homeodomain  6 tftkeqleeLek.lFee..nrypsaeereeLAkklgLeerqVkvWFqNrRak 54
                 t+ ke +e+L++ l+    ++yps +++ +L++++ Le + + +WF N R +
   EFC38393.1  8 TLPKEAVEQLKEwLYDHlfHPYPSDAQKNQLSNQTSLEMKSINNWFINARRR 59
                 44556677776635664569*****************************977 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   9.3    0.0022        13      53     107 ..     130     184 ..     122     201 .. 0.55

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0022
      FAM176  53 rlkkkkkklkeesekasededeeeeeeeedsseseaeeelsefertlsvnvftsa 107
                 r++++++++k + e++se+ede e+e++ed+ + +++e++s+++ + s   ++++
  EFC38393.1 130 RPRRTRQTRKVNVESDSESEDEVETEDDEDEYKMDVDEDTSTTNDEQSDMSYSES 184
                 4555555555555555555555555555555555656666555555433333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (210 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1905  (0.106252); expected 358.6 (0.02)
Passed bias filter:                      683  (0.0380947); expected 358.6 (0.02)
Passed Vit filter:                        91  (0.00507558); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1283.75
//
Query:       EFC38394.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-24   86.6   0.2    2.6e-24   85.7   0.2    1.5  1  ADH_zinc_N     Zinc-binding dehydrogenase
    3.1e-20   73.6   0.0    5.4e-20   72.8   0.0    1.4  1  ADH_zinc_N_2   Zinc-binding dehydrogenase
    5.6e-09   35.9   0.0    1.8e-08   34.2   0.0    1.9  1  ADH_N          Alcohol dehydrogenase GroES-like domain
     0.0047   16.2   0.0     0.0086   15.4   0.0    1.4  1  AlaDh_PNT_C    Alanine dehydrogenase/PNT, C-terminal domain
  ------ inclusion threshold ------
      0.039   14.4   0.0      0.064   13.7   0.0    1.3  1  NAD_binding_7  Putative NAD(P)-binding


Domain annotation for each model (and alignments):
>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.7   0.2   7.1e-28   2.6e-24       1     126 [.     181     308 ..     181     312 .. 0.91

  Alignments for each domain:
  == domain 1  score: 85.7 bits;  conditional E-value: 7.1e-28
                 HHHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTTESEEEETTTC.HHHHHHHHHTTTSSEEEEEESSCSHHHHHHHHHCEEEEEEEEECSC.TSSEEEE CS
  ADH_zinc_N   1 gvGlaavqlAkalGaeviavdsseeklelakklGadevinykea.dlverikeltggegvdvvfecvGsgatleaalkllkpgGrlvvvGg.gkgeeef 97 
                 gv l+++q+A  +G++v++ +ss+ekl+la++lGa ++inyk+  d++ +++e+t+g+gvd v+e+ G + tl+++l++++ gG + ++G+  k   ++
  EFC38394.1 181 GVSLFGLQFAVRAGCQVMVLSSSDEKLKLAQSLGASFLINYKKHpDWEIKVREITNGKGVDHVLEVGG-EGTLNRSLDAVRLGGHVHIIGVlAKSAGTC 278
                 899*****************************************************************.**********************84444445 PP

                 EHHH..HHHTT-EEEEE-SSCHHHHHHHHHH CS
  ADH_zinc_N  98 dlrn..lllkeksilGsllgslreefkeald 126
                 + +   +l+ +++++G+  gs r  f+++++
  EFC38394.1 279 SGFGekVLYSSVQMRGIYIGS-RGVFERMNK 308
                 55444599*************.888887776 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.8   0.0   1.5e-23   5.4e-20       1     133 []     213     346 ..     213     346 .. 0.80

  Alignments for each domain:
  == domain 1  score: 72.8 bits;  conditional E-value: 1.5e-23
                   TT-SEEEETT.STTHH....HHH-TT-EEEEEES-HHHHH.HHHHHHEEEEEEEEE----.S-EEE-CHHHCTTT-EEEE--GGG...-.....-HH CS
  ADH_zinc_N_2   1 lGAdevidyr.tedfe....aatggegvDvvldtvggealleaslkvlpggGrlvsiggpplsaallkpakkrkgrsvkyeflfsmkas....aqad 88 
                   lGA   i+y+  +d+e    + t+g+gvD+vl+  gge +l +sl++++ gG++  ig   l++  +  +    g +v y+ +  m  +      + 
    EFC38394.1 213 LGASFLINYKkHPDWEikvrEITNGKGVDHVLEV-GGEGTLNRSLDAVRLGGHVHIIGV--LAKSAGTCS--GFGEKVLYSSVQ-M--RgiyiGSRG 301
                   8********************************6.666666*******88788866653..122222222..334444444444.3..334775667 PP

                   HHHHHHHHHHHHH----EEEEEEGGGHHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  89 ileelaalieeGklrpvvdrvfpleeaaeAhrylesgrarGKiVl 133
                   ++e++ + ie ++++pvvdrvf++e+++eA++yl+sg+++GK+V+
    EFC38394.1 302 VFERMNKSIEINEIKPVVDRVFDFENVKEAFEYLASGKHFGKVVI 346
                   7*******************************************7 PP

>> ADH_N  Alcohol dehydrogenase GroES-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.2   0.0   5.1e-12   1.8e-08       2     108 ..      36     137 ..      35     138 .. 0.90

  Alignments for each domain:
  == domain 1  score: 34.2 bits;  conditional E-value: 5.1e-12
                 TEEEEEEEEEEE-HHHHHHHTTS.TTTTSSSSEE---EEEEEEEEESTT-CS--TT-EEEE-SEEE-SSSHHHHTT-GGG-TTBEETTTSS-SSSBSEE CS
       ADH_N   2 gevlikvkaagiCgsDlhilkgg.kelevklplilGHEivGeveevgpevkklkvGdrVvvepliscgeCaaCkegeenlCeeakllgvsldGgfaeyv 99 
                 ++vl++++aa+++  D+ i +g+  +++ +++li+  + +G+v+++g+ev+++++GdrV+  ++      +++++g  +  +  + lg++++G +a+y 
  EFC38394.1  36 KQVLVRLHAASLNFRDILISRGQfGSFSFPPGLIPLSDGAGQVVALGDEVTSFQIGDRVCGTFF------ETWQDGPITPDNVSRALGATVPGVLAQYR 128
                 79********************8888889999***************************99666......56888888888889999999999999999 PP

                 EECGGGEEE CS
       ADH_N 100 vvpekklvk 108
                 v++e+ l+k
  EFC38394.1 129 VFEESALIK 137
                 999998886 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   2.4e-06    0.0086      29      77 ..     172     220 ..     155     236 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 2.4e-06
                  -EEEEESTSHHHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTTTCECEE CS
  AlaDh_PNT_C  29 akvlviGgGvaGlqAiatakglgakVtvlDvrparleqleslgakfvev 77 
                   +vl+iG G + l  ++ a++ g +V+vl  + ++l+  +slga+f+  
   EFC38394.1 172 ETVLIIGTGGVSLFGLQFAVRAGCQVMVLSSSDEKLKLAQSLGASFLIN 220
                  379*****************************************98754 PP

>> NAD_binding_7  Putative NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   1.8e-05     0.064       7      42 ..     171     205 ..     170     258 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.8e-05
  NAD_binding_7   7 gkkvlvvGgGevAarkvrklleagakvtvvapevke 42 
                    g++vl++G G v +  ++  ++ag++v v++    e
     EFC38394.1 171 GETVLIIGTGGVSLFGLQFAVRAGCQVMVLSSS-DE 205
                    689***************************998.22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       280  (0.0156172); expected 358.6 (0.02)
Passed bias filter:                      269  (0.0150036); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2349.27
//
Query:       EFC38395.1  [L=563]
Description: [Fe]-hydrogenase maturation protein HydG [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.2e-24   84.0   0.0    1.4e-23   82.8   0.0    1.7  1  BATS         Biotin and Thiamin Synthesis associated domain
    1.4e-06   28.8   0.3    4.8e-06   27.1   0.0    2.1  2  Radical_SAM  Radical SAM superfamily
  ------ inclusion threshold ------
      0.049   13.2   1.5        9.1    5.9   0.0    2.7  2  Sigma70_r4   Sigma-70, region 4
        0.7   10.0   4.3        1.1    9.4   0.1    2.8  2  MYO10_CC     Unconventional myosin-X coiled coil domain


Domain annotation for each model (and alignments):
>> BATS  Biotin and Thiamin Synthesis associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.8   0.0   3.2e-27   1.4e-23       1      85 [.     363     472 ..     363     473 .. 0.97

  Alignments for each domain:
  == domain 1  score: 82.8 bits;  conditional E-value: 3.2e-27
                 E--B----.............TCCCCHHHHHHHHHHSTTSECCCTCHH-HHHHHHHHHCCT--EEE-C---TTTGGG.............SESSTT-TC CS
        BATS   1 siprlrpi.............kdtpllkiiaalRlllPkagillsgResaefrdqlllklGansisagsktevggya.............flttdgrsl 73 
                 s+prl+p+             +d +++k++a+lR+ +P++g++ls+Re++++r++ll  lG++++sags+t+vggy+             f ++d+r+ 
  EFC38395.1 363 SVPRLKPAsgsevsvhvpnlvSDAQFKKLVAVLRCSVPYTGMILSTRENPDMRRELL-SLGISQMSAGSNTAVGGYEkkederddysmgqFSLGDHRNT 460
                 89******999999999999999999*******************************.***************************************** PP

                 CCCHHHHHHTT- CS
        BATS  74 eedvkmleelGl 85 
                  e+++ l e G+
  EFC38395.1 461 GEVIRELLETGY 472
                 *********998 PP

>> Radical_SAM  Radical SAM superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       1.4   6.4e+03     122     140 ..      80      99 ..      63     104 .. 0.65
   2 !   27.1   0.0   1.1e-09   4.8e-06       3     144 ..     179     325 ..     177     346 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.4
                  T.CTSHHHHHHHHHHHHHHT CS
                  x.xxxxxxxxxxxxxxxxxx RF
  Radical_SAM 122 n.rghtfeevlealeklrea 140
                  + + ++ e+v + l+++r+ 
   EFC38395.1  80 KeKAKDHEHVRQILKRARDQ 99 
                  35566778888888888876 PP

  == domain 2  score: 27.1 bits;  conditional E-value: 1.1e-09
                  EESEESS--TTTSCCTTHHHHHHHHHHHHHHHHHHHHHHHHHTTSEEEEEESSTGGGSTTHHHHHHHHHHTC.......CCTEEEEEEECSSCHGHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxxxxx RF
  Radical_SAM   3 vtrgCnlrCsfCarpetvrregrgrslsveeileevkelkaekgvkevilgggepllypdfvellerlakla.......vpgiritvetngtlpdeek 93 
                  +++ C + C +C  + +  +e +   ls ee+++ev++l +++g k ++++ ge   y  f++++++l   a        + +ri ve++ + +    
   EFC38395.1 179 TSNYCVGSCLYCGYRGS-NKEMPRSALSDEEVIREVEAL-QKQGHKRILMLCGESPKYT-FEDFMRQLQVAAdvktephGDVRRINVEIPQLSV--SD 271
                  5789***********97.999******************.9***555555555554444.66666666666667799*999***********95..89 PP

                  HHHHHHTT.-SEEEEEEBSSSHHHHHHHHT...CTSHHHHHHHHHHHHHHTTSET CS
                  xxxxxxxx.xxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxx RF
  Radical_SAM  94 lerllelg.vdrvslgleaaddekvlklmn...rghtfeevlealeklreagikr 144
                   +rl+  + v ++ l  e+++   ++k m+    ++ + ++l++++k+   g+++
   EFC38395.1 272 FRRLKATNkVGTYILFQETYHRQ-THKEMHpfgTKGQYYDRLQTMDKAFVTGLDD 325
                  99999999777777777888887.9999985555555566666666666666665 PP

>> Sigma70_r4  Sigma-70, region 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.3     0.003        13      35      46 ..      87      98 ..      86      99 .. 0.90
   2 ?    5.9   0.0     0.002       9.1      17      35 ..     129     147 ..     126     149 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.003
                HHHHHHHHHHHH CS
  Sigma70_r4 35 erVrqiekrAlr 46
                e+Vrqi+krA++
  EFC38395.1 87 EHVRQILKRARD 98
                8*********86 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.002
                 HTTT--HHHHHHHHTS-HH CS
  Sigma70_r4  17 fgeglTleEIgerlgiSre 35 
                 + +gl+le+++  l+i++e
  EFC38395.1 129 YIQGLSLEDTATLLNIPEE 147
                 789**************98 PP

>> MYO10_CC  Unconventional myosin-X coiled coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   1.1      0.19   8.4e+02      31      47 ..      86     102 ..      69     104 .. 0.65
   2 ?    9.4   0.1   0.00024       1.1      14      34 ..     211     231 ..     207     235 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.19
    MYO10_CC  31 ceesrqelqrlRdeelk 47 
                  e+ rq l+r Rd+ l 
  EFC38395.1  86 HEHVRQILKRARDQALL 102
                 5788999******9886 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00024
    MYO10_CC  14 rEIerLqrqkedqvsslcees 34 
                 rE+e+Lq+q  +++++lc es
  EFC38395.1 211 REVEALQKQGHKRILMLCGES 231
                 8*****************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (563 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       878  (0.0489709); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.46
# Mc/sec: 3715.04
//
Query:       EFC38396.1  [L=354]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.7e-78  262.1   0.1    6.4e-78  261.9   0.1    1.0  1  Aldo_ket_red  Aldo/keto reductase family
  ------ inclusion threshold ------
       0.02   14.0   0.0      0.031   13.4   0.0    1.2  1  HpuA          Haemoglobin-haptoglobin utilisation, porphyrin 


Domain annotation for each model (and alignments):
>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  261.9   0.1   7.1e-82   6.4e-78       2     291 ..      16     340 ..      15     343 .. 0.95

  Alignments for each domain:
  == domain 1  score: 261.9 bits;  conditional E-value: 7.1e-82
                   EEEE-SSS-ST.....TS-HHHHHHHHHHHHHTT--EEE--TT-TTTHHHHHHHHHHHH-TTTGGG-EEEEEE...............--SSSTTSS CS
  Aldo_ket_red   2 lglGtwqlgsk....eeiskeealellrraleaGinffDtAevYgkgqseellGealkksrkkreeviiatKv...............dlrdaeiks 79 
                   l+lG +++gs     ++ ++ee+l +l++a + GinffDtA++Y +g+se++lG+++k+ + +ree+++atKv               +   +++  
    EFC38396.1  16 LCLGCMSFGSSkwlpWVLEEEESLTILKKAWDLGINFFDTANIYSNGESERILGKFIKEFNIPREEIVVATKVcapldrsgeqklimvGSQAKPNTM 112
                   9***************************************************************************************9******** PP

                   SS-HHHHHHHHHHHHHHHT-S-EEEEEE-S--TTS-.HHHHHHHHHHHHHTTSEEEEEEES--HHHHHHH....HHTTT--EEEEE-B-BTT-HHHH CS
  Aldo_ket_red  80 glskeniresleeslkrLgtdyvDllllHrpdpslpsieevldaleelvkeGkiraiGvSnfsveqleka....kkkkkvkivavqveynllrelee 172
                   gls+++i++++e+sl+rLg+dy+Dl+ +Hr+d ++p iee++dal++lvk+Gk+r+iG S   ++q  ka    +kk+ +k+++ q+ ynl  ++ee
    EFC38396.1 113 GLSRKHIMHAVEDSLQRLGLDYIDLYIIHRWDEQTP-IEETMDALHDLVKSGKVRYIGASTMFAWQFAKAqhyaEKKGLTKFISMQNLYNLIYREEE 208
                   ************************************.***********************98888888888999*********************** PP

                   TTHHHHHHHTT-EEEEBSTTGGGTTGTTTSS---SSSCCC-------.............TS-HHHHHHHHHHHHHHHHTT--HHHHHHHHHTTSTT CS
  Aldo_ket_red 173 egllelckkkgvpliaysplggGlltgkyqseedkedkeprkdlkrd.............ertsknldaaeelselakehgvslaqlalryalsqpa 256
                   +++ +lc ++gv l +++pl++G+l +  +  +  e+ ++  +++++             + t++  ++++++se+ak+++vs+aq+al+++ls+p+
    EFC38396.1 209 REMNPLCVDQGVSLTPWGPLSNGMLARAHEFVNAEEKATETTENGSKrqstdfvqslfkdKLTEGDKETLRKVSEIAKNRNVSPAQIALAWLLSKPG 305
                   **************************988776666665555555555678999******************************************** PP

                   -SEEEE--SSHHHHHHHHGGGG----HHHHHHHHH CS
  Aldo_ket_red 257 vgivipgasnieqlednldalelklseeevaelde 291
                   v+++++ga+++  +e n++ale++l+eee + l+ 
    EFC38396.1 306 VVSPVIGATKAINVELNVQALEIQLTEEEKKSLEG 340
                   ****************************9988875 PP

>> HpuA  Haemoglobin-haptoglobin utilisation, porphyrin transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   3.5e-06     0.031     230     306 ..      43     119 ..      38     121 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.5e-06
        HpuA 230 kdvgidgldfsgtae..sdgktgklegkffgkfnsyrdsevsiggkvtfdddksldtvfggveyekdrnettdtsldhl 306
                 k +   g++f  ta+  s+g + ++ gkf+ +fn     e+ +  kv    d+s +  +  v  + ++n t  +s +h+
  EFC38396.1  43 KKAWDLGINFFDTANiySNGESERILGKFIKEFNIP-REEIVVATKVCAPLDRSGEQKLIMVGSQAKPN-TMGLSRKHI 119
                 555666999999996669****************98.67999****************999*99****9.988888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       614  (0.0342462); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 2348.00
//
Query:       EFC38397.1  [L=144]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0043   16.9   0.0     0.0059   16.5   0.0    1.2  1  AhpC-TSA  AhpC/TSA family


Domain annotation for each model (and alignments):
>> AhpC-TSA  AhpC/TSA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   3.3e-07    0.0059      18      85 ..      46     114 ..      36     130 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3.3e-07
                 EECHHH.TTSEEEEEEESTST-CCHHHHHHHHHHCHHHCCCTTEEEEEEESSSCHHHHHHHHH-H.SSE CS
    AhpC-TSA  18 vslsdy.kgkpvvlffypkdwcpvCttelpalaklyeefkergvevigvsvdspeshkkfiekeslnfp 85 
                 vs++d+ k+++v+l+f +   c +C++ + ++ + +  + ++++  + v  +s+++  +f  + +++ p
  EFC38397.1  46 VSVADLsKKHVVLLVFLRYFGCVFCQRSIVDIVNSLSSLIKLNCIPVFVHQESEQEADEFFSRAGMPKP 114
                 8999**666889999999999***********************************9999988886655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (144 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       577  (0.0321825); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 948.70
//
Query:       EFC38398.1  [L=382]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.029   14.4   0.5      0.087   12.9   0.5    1.8  1  RAP       RAP domain


Domain annotation for each model (and alignments):
>> RAP  RAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.5   4.9e-06     0.087       9      56 ..      29      76 ..      23      78 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.9e-06
         RAP  9 yykns.knltgktklKkriLsklGykvinIpyfeWnqlknkedkveylk 56
                +  n+ +  t++  l++ +Ls    + ++Ip +++ q  + +  ++yl 
  EFC38398.1 29 FNANNtQSTTPNLNLQQQHLSISQQNTVTIPSHQFSQP-TSHLAENYLH 76
                6666636666*************************996.8888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (382 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1672  (0.0932567); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 2100.92
//
Query:       EFC38399.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.41   10.4   0.1       0.41   10.4   0.1    2.2  2  DUF3989         Protein of unknown function (DUF3989)
        0.8    9.3  31.1      0.014   15.0   8.5    2.9  2  Virul_fac_BrkB  Virulence factor BrkB


Domain annotation for each model (and alignments):
>> DUF3989  Protein of unknown function (DUF3989)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   1.0      0.75   6.7e+03      34      45 ..     179     190 ..     169     193 .. 0.71
   2 ?   10.4   0.1   4.6e-05      0.41      28      75 ..     211     257 ..     203     263 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 0.75
     DUF3989  34 llllfallslYm 45 
                 ++++ +++sl+ 
  EFC38399.1 179 MFIIVSVVSLFH 190
                 777777777765 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 4.6e-05
     DUF3989  28 livvllllllfallslYmtvssiydigredgerlqieHirrlelpvqi 75 
                  +vv  +l++ a++ l+  +  i  i+r+  +rl i Hi++l+ + ++
  EFC38399.1 211 FAVVSCMLVFKAVFTLWSGIVVIKAIKRN-THRLSIAHIEPLQQKGFV 257
                 578999********************997.689*********976655 PP

>> Virul_fac_BrkB  Virulence factor BrkB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0  17.1      0.48   4.3e+03     108     199 ..     119     215 ..      29     221 .. 0.74
   2 ?   15.0   8.5   1.6e-06     0.014      74     184 ..     218     328 ..     193     337 .. 0.73

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.48
  Virul_fac_BrkB 108 flrkrllsllllllllvllllslvlsvflqslllasa......pllglglelsellllqllrwlvallllvlafallYrvlpnvkvrlraalpGa 196
                     +l++ ++++lll  + +++++s v ++fl+s+ +a a      + l  gl + +  l+++  ++++ ++ ++ f+ l  +lp++  +++  ++ a
      EFC38399.1 119 LLSTASDYVLLLSFVTLFVIISYVQTIFLNSSYRAKAlsaklaNNLKKGLYVITG-LFSFSMFIIVSVVSLFHFLHLMDILPQTPITISNSVIFA 212
                     6777889999999999999999999999999888888665444333434333333.566666656666666667777777888777777776666 PP

  Virul_fac_BrkB 197 lla 199
                     +++
      EFC38399.1 213 VVS 215
                     655 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.6e-06
  Virul_fac_BrkB  74 gllglavllwsasggvsalrralnk..iygv..eesrsflrkrllsllllllllvllllslvlsvflqslllasapllglglelsellllqllrw 164
                      ++  +++lws++ +++a++r   +  i ++   ++++f+++++  +l+++ll+ +++ls++l ++++ +++    + g +++++++ ++q+ + 
      EFC38399.1 218 LVFKAVFTLWSGIVVIKAIKRNTHRlsIAHIepLQQKGFVKRQVNPFLITILLISAMVLSVFLHIVAGGVAT---LVGGSENTVVKI-VWQVSTS 308
                     456667777**************995555665434678*********9999999888888888888877444...367777777777.7999999 PP

  Virul_fac_BrkB 165 lvallllvlafallYrvlpn 184
                     + +l++  l +++ Y ++ +
      EFC38399.1 309 FSVLVCSSLSMSMFYPMFIH 328
                     87777777777777766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1403  (0.0782531); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2510.81
//
Query:       EFC38400.1  [L=297]
Description: Hypothetical protein NAEGRDRAFT_73878 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00045   20.1   0.1    0.00084   19.2   0.1    1.4  1  F-box-like  F-box-like
     0.0038   17.3   0.2     0.0078   16.3   0.1    1.6  2  SPRY        SPRY domain
  ------ inclusion threshold ------
      0.019   14.9   0.0      0.039   13.8   0.0    1.5  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.1   1.4e-07   0.00084       2      35 ..      15      55 ..      14      60 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 1.4e-07
  F-box-like  2 srLPdEiLlqIFsyL.pps.d.....LlrlalVCrrWrrva 35
                + +PdE+ ++IF+++ pp+ +     +++l  VC+r++ v 
  EFC38400.1 15 LEIPDELWVEIFRWIkPPNnEewlffMINLPMVCKRFYHVL 55
                689************7777537999999999*******996 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.6   9.8e+03      79      85 ..      97     103 ..      91     115 .. 0.79
   2 !   16.3   0.1   1.3e-06    0.0078       3      83 ..     152     233 ..     150     265 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.6
                 EEEEEET CS
        SPRY  79 elsFtkn 85 
                 e++F+ n
  EFC38400.1  97 EINFYRN 103
                 8999988 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 1.3e-06
                 EEEEEET..CCTSSEEEEEEEETTSSSSSTSSSTSSTTEEEEETETTEEE..EETESCEEEESSSSTTSEEEEEEETTTTEEEEE CS
        SPRY   3 yfevkiq..saeggsisvGlateqtdlsdksgegddrgswglcgdngtrt..saeqskaygkqparegdviGvalDleegelsFt 83 
                 yfe       +   ++ +G++ e+ +  ++ + g+d+ s+g+   +g ++   +++++ yg  ++ ++ v G ++D+++ +l + 
  EFC38400.1 152 YFECVFMdkIDSTDNVLFGIVLENQS--NEGYIGSDKNSVGYYFSDGAIYygGKSVKSGYGI-KMYKQLVLGLLIDTDNLTLEYV 233
                 666544445458899999*****999..888999******************9*********.9999***********9888774 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   6.5e-06     0.039       2      39 ..      13      57 ..      12      64 .. 0.93

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 6.5e-06
                HHHHS-HHHHHHHHHTS-HHH.......HHHHCTT-HHHHHHHTT CS
       F-box  2 tlsrLPsevlrhILerLplsd.......llalrrVSkgwrilids 39
                ++++ P+e++ +I+++  +          ++l  V+k+++ ++++
  EFC38400.1 13 HILEIPDELWVEIFRWIKPPNneewlffMINLPMVCKRFYHVLRM 57
                799*************************************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       463  (0.0258241); expected 358.6 (0.02)
Passed bias filter:                      265  (0.0147805); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.42u 0.22s 00:00:00.64 Elapsed: 00:00:00.39
# Mc/sec: 2274.13
//
Query:       EFC38401.1  [L=1030]
Description: TCCD-inducible-PARP-like domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-26   92.6   2.3    2.3e-26   92.6   2.3    2.9  2  PARP      Poly(ADP-ribose) polymerase catalytic domain
    1.1e-25   90.0   0.6    6.7e-14   52.2   0.1    2.8  2  Ank_2     Ankyrin repeats (3 copies)
    4.6e-14   51.1   0.9    0.00089   19.5   0.0    4.0  3  Ank_3     Ankyrin repeat
    5.4e-12   46.0   0.2    9.9e-05   22.8   0.0    3.7  4  Ank_4     Ankyrin repeats (many copies)
    5.8e-12   45.6   0.1     0.0082   16.4   0.0    3.9  3  Ank_5     Ankyrin repeats (many copies)
    4.8e-11   42.6   3.7      0.022   15.2   0.1    4.0  4  Ank       Ankyrin repeat
  ------ inclusion threshold ------
          2    8.1  41.3       0.12   12.2   9.1    3.3  3  ERM       Ezrin/radixin/moesin family
        6.8    5.5  71.7     0.0076   15.2  20.0    4.2  4  Spc7      Spc7 kinetochore protein


Domain annotation for each model (and alignments):
>> PARP  Poly(ADP-ribose) polymerase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   2.5      0.71   1.6e+03       9      48 ..     711     746 ..     700     795 .. 0.60
   2 !   92.6   2.3     1e-29   2.3e-26      19     194 ..     864    1028 ..     847    1029 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.71
                 HHHHHTS-TTTT.EEEEEEEEEEEEETTHHHHCGCCGGSS- CS
        PARP   9 kylkktldstha.yklkileifrvqregeaerfqekkklrn 48 
                 ++++ ++++ h+  k++il++++     e+++f+++k+++ 
  EFC38401.1 711 NEFELKMKKNHEnLKIEILNLEK-----EKKQFSNSKSKKS 746
                 44444444444333444444443.....4555555544332 PP

  == domain 2  score: 92.6 bits;  conditional E-value: 1e-29
                  TTEEEEEEEEEEEEET...THHHHCGCCGG.....SS-EEEEEEEE-GGGHHHHHHH-S--S-TTS-GGGSTTSSSEEEBSSHHHHHGGG--BSSS- CS
        PARP   19 hayklkileifrvqre...geaerfqekkk.....lrnrrlLfHGsrltnvasilsqGLriappeapvtGymfGkGiYfAddaskSanYcktsekkg 107 
                   +y+++i  ++ vq+e   + +++f++ k      ++n+++L+HG++ ++v  i ++G+  + ++a+++G  fG GiYfA+  skS +Yc++ ++++
  EFC38401.1  864 ISYQDSINSLQ-VQTEnisKTSKSFEWMKTiglnsNMNEKYLWHGTKPEFVNTIAEHGF--DERVANLNG-LFGAGIYFAEYCSKSDQYCTP-DHSN 955 
                  44444444332.233300034556777666888779***********************..*******98.5*******************9.6677 PP

                  EEEEEEEEEE--SEEEESS--TGCCGGTT-SEEEE-EEEEEGG.EEETT....E--S-EEE-S--SSSEEE-EEEESSGGGEEEEEEEEEE CS
        PARP  108 sglllLaeValGdikeltkadylekakkgkksvkgkgktepesivekdg....vPlgkssatkyesseleyneyvvydkeqvrlkYLlevk 194 
                  +  llL++V +G   ++tk+            v  ++++ p    e  g    v   +s+  ++++s+ +y+e++vydk q+++++++++k
  EFC38401.1  956 EYTLLLCRVVMGRQIHFTKQ------------VMNNQRRPP----EISGsnnrVY--DSVIGQSNTSTNSYREFIVYDKCQCYPEFIIKYK 1028
                  7779*********3333332............222222222....2222210122..2244556666688*******************97 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.2   0.1     3e-17   6.7e-14       4      81 ..      12     103 ..      10     105 .. 0.78
   2 !   45.4   0.0   4.2e-15   9.4e-12      22      80 ..      74     134 ..      65     137 .. 0.80

  Alignments for each domain:
  == domain 1  score: 52.2 bits;  conditional E-value: 3e-17
       Ank_2   4 AakngnlelvklLlegadpn.k.ngktaLhyAakngnleivklLleh...........adndgrtpLhyAarsghleivklLl.ekgadinl 81 
                 Aa++g+ + ++   ++ d+n k +g t L++A+++g+leivklLl+            +d d  tpL+ A+++g+leivklLl +k +d+nl
  EFC38401.1  12 AARDGKIDEFNNYFNEQDVNnKsEGCTMLIIACQKGHLEIVKLLLSCktidvnlgfdvFDVDFDTPLYTACQNGYLEIVKLLLsCKTIDVNL 103
                 56666444444444778998646**********************9446665666555447788*******************555999986 PP

  == domain 2  score: 45.4 bits;  conditional E-value: 4.2e-15
       Ank_2  22 pnkngktaLhyAakngnleivklLleh..ad.ndgr..tpLhyAarsghleivklLlek.gadin 80 
                 +     t+L++A++ng+leivklLl+   +d n gr   pL+ A+++ghleivk Ll++ +++in
  EFC38401.1  74 F----DTPLYTACQNGYLEIVKLLLSCktIDvNLGRkfPPLYTACQNGHLEIVKQLLQHpNININ 134
                 3....4*******************96686665555337******************87566666 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.1   1.4e-05     0.032       1      30 [.      35      64 ..      35      65 .. 0.87
   2 !   12.8   0.0   6.3e-05      0.14       4      30 ..      76     102 ..      73     103 .. 0.87
   3 !   19.5   0.0     4e-07   0.00089       5      30 ..     109     134 ..     106     134 .. 0.95

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.4e-05
       Ank_3  1 nGetpLhlAarsgnleivkfLlenkgadvn 30
                +G+t+L +A+  g+leivk+Ll  k +dvn
  EFC38401.1 35 EGCTMLIIACQKGHLEIVKLLLSCKTIDVN 64
                599*******************94467776 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 6.3e-05
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadvn 30 
                 tpL++A+ +g leivk+Ll  k +dvn
  EFC38401.1  76 TPLYTACQNGYLEIVKLLLSCKTIDVN 102
                 9******************94467776 PP

  == domain 3  score: 19.5 bits;  conditional E-value: 4e-07
       Ank_3   5 pLhlAarsgnleivkfLlenkgadvn 30 
                 pL++A+ +g+leivk Ll+++++++n
  EFC38401.1 109 PLYTACQNGHLEIVKQLLQHPNININ 134
                 9**********************998 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   2.2e-06     0.005      25      55 .]      28      56 ..      21      56 .. 0.88
   2 !   14.1   0.0   2.3e-05     0.052      24      55 .]      66      94 ..      63      94 .. 0.84
   3 !   22.8   0.0   4.4e-08   9.9e-05       3      54 ..      76     125 ..      75     126 .. 0.90
   4 !    8.7   0.0    0.0012       2.7       4      30 ..     109     136 ..     106     142 .. 0.73

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 2.2e-06
       Ank_4 25 adinaqdnrsGetalhiAakrgnveilklLl 55
                +d+n    ++G t l+iA+++g++ei+klLl
  EFC38401.1 28 QDVNNK--SEGCTMLIIACQKGHLEIVKLLL 56
                577776..67********************8 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 2.3e-05
       Ank_4 24 gadinaqdnrsGetalhiAakrgnveilklLl 55
                g d+  +   + +t+l+ A+++g++ei+klLl
  EFC38401.1 66 GFDVFDV---DFDTPLYTACQNGYLEIVKLLL 94
                5565555...789******************8 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 4.4e-08
       Ank_4   3 taLhyaaisgrlelvrlLl.ekgadinaqdnrsGetalhiAakrgnveilklL 54 
                 t+L  a++ g le+v+lLl +k +d+n    ++ +++l+ A+++g++ei+k L
  EFC38401.1  76 TPLYTACQNGYLEIVKLLLsCKTIDVNL---GRKFPPLYTACQNGHLEIVKQL 125
                 8999***************558899988...689****************966 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.0012
       Ank_4   4 aLhyaaisgrlelvrlLlek.gadinaq 30 
                 +L  a++ g+le+v+ Ll++ +++in++
  EFC38401.1 109 PLYTACQNGHLEIVKQLLQHpNININYT 136
                 5666777777777777777777777776 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   3.7e-06    0.0082       9      43 ..      31      59 ..      22      73 .. 0.80
   2 !   14.6   0.0   1.4e-05     0.031       8      43 ..      68      97 ..      63     104 .. 0.81
   3 !   13.4   0.0   3.2e-05     0.071       1      38 [.      93     129 ..      93     136 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 3.7e-06
       Ank_5  9 vnrldgggntpLhvAakygaadvvrlLlargadln 43
                +n ++g+  t L++A+ +g++++v+lLl    +++
  EFC38401.1 31 NNKSEGC--TMLIIACQKGHLEIVKLLL----SCK 59
                4556666..*******************....444 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 1.4e-05
       Ank_5  8 dvnrldgggntpLhvAakygaadvvrlLlargadln 43
                dv + d +  tpL +A+ +g++++v+lLl    +++
  EFC38401.1 68 DVFDVDFD--TPLYTACQNGYLEIVKLLL----SCK 97
                66677777..*******************....554 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 3.2e-05
       Ank_5   1 LlehgpadvnrldgggntpLhvAakygaadvvrlLl.ar 38 
                 Ll++  +dvn  +++   pL +A+ +g++++v+ Ll  +
  EFC38401.1  93 LLSCKTIDVNLGRKF--PPLYTACQNGHLEIVKQLLqHP 129
                 7888899****9999..******************9433 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.1   9.8e-06     0.022       2      28 ..      36      64 ..      35      66 .. 0.84
   2 !   14.9   0.0   1.3e-05     0.028       3      28 ..      75     102 ..      73     104 .. 0.83
   3 !   11.2   0.0   0.00018      0.39       5      29 ..     109     133 ..     107     136 .. 0.84
   4 ?   -4.2   0.1         8   1.8e+04      16      29 ..     504     515 ..     503     515 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 9.8e-06
                SBBHHHHHHHHTTHHHHHHHH.TT.TSTT CS
         Ank  2 GnTPLHlAatngkkriiklLL.hG.Anln 28
                G+T L +A++ g+++i+klLL +   ++n
  EFC38401.1 36 GCTMLIIACQKGHLEIVKLLLsCKtIDVN 64
                9********************65345666 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 1.3e-05
                 BBHHHHHHHHTTHHHHHHHH.TT.TSTT CS
         Ank   3 nTPLHlAatngkkriiklLL.hG.Anln 28 
                 +TPL  A++ng ++i+klLL +   ++n
  EFC38401.1  75 DTPLYTACQNGYLEIVKLLLsCKtIDVN 102
                 6*******************65345666 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00018
                 HHHHHHHHTTHHHHHHHH.TTTSTTC CS
         Ank   5 PLHlAatngkkriiklLL.hGAnlna 29 
                 PL  A++ng+++i+k LL h  n+n+
  EFC38401.1 109 PLYTACQNGHLEIVKQLLqHP-NINI 133
                 9999**************663.6664 PP

  == domain 4  score: -4.2 bits;  conditional E-value: 8
                 HHHHHHHTTTSTTC CS
         Ank  16 riiklLLhGAnlna 29 
                 +++++LL + nln+
  EFC38401.1 504 NMASDLL-S-NLNI 515
                 4789999.6.8885 PP

>> ERM  Ezrin/radixin/moesin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9  19.8     0.018        40      15     209 ..     145     451 ..     142     455 .. 0.67
   2 ?   -0.6   0.3      0.44   9.8e+02      87     133 ..     452     498 ..     448     577 .. 0.70
   3 ?   12.2   9.1   5.3e-05      0.12      19     118 ..     691     776 ..     685     884 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.018
         ERM  15 kqlqeeaekaqeaLreseetaelLaekarraeeea.elLeqkaaeaeeeiqr..lkesaekeeeekeklerklreaeleaarleeeserkeeeaerLke 110
                 + +++++ek q+ L+e+ e+ +  + +++r+e+e+ ++Le ++ e e+  ++  lk+++e++e ek++    + e  +++  l +++++  +++e+  e
  EFC38401.1 145 QTIKSDMEKEQQLLKEQSEQLKFNQLEMERLERERiKKLEMERIEKERIEKEclLKIERERKELEKKQSFIITSETFSKLCSLNQQVDNNRRKVEKQFE 243
                 566777777777777777776666666666666654456666665555554422555666666666665555555555555555555555555555555 PP

         ERM 111 eleeareaeeeakekllealstpsks...........eseenveeseteeeeensee.......................................... 156
                  ++    + + +ke   e l+  ++            +++ n e++         e+                                          
  EFC38401.1 244 SIQSFSSSIQIKKEFQDEYLTICNNLnnccnlierltSNNYNIENN---------EHlltinnlmnnirtilefinnqkylfklqsylevlseklelfn 333
                 5555555555555444444444433333344443332112222222.........22566677777999****************************** PP

         ERM 157 ...............................................................esaeletde...veklsleieeeRvtylekskrlqe 189
                                                                                e++e+ ++    +++ s+ +e+   t  +++ r+  
  EFC38401.1 334 efnsqfikqelfdsiemseqsikninilisdndqmnilelynyyqkqelncklliqetipyiiEKYEMLQNIiniMNNYSNLSEQ-FKTIQRQKTRITR 431
                 ****************************************999998887777666666666665555554436644444444444.458888889**** PP

         ERM 190 qLkeLkseleqlkdeekqte 209
                  L++L+ ++e lkde k  +
  EFC38401.1 432 NLNMLNLDIEGLKDELKHVN 451
                 ***************98765 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.44
         ERM  87 aeleaarleeeserkeeeaerLkeeleeareaeeeakekllealstp 133
                  e e++++++e + ke +  +Lk++l+e  ++++e k k l++++  
  EFC38401.1 452 NEDEMNDIKDEIQIKEFNLIELKSNLKENIQKLNEIKMKFLQLTTIG 498
                 56677788888888888888888888888888888888888887766 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 5.3e-05
         ERM  19 eeaekaqeaLreseetaelLaekarraeeeaelLeqkaaeaeeeiqrlkesaekeeeekeklerklreaeleaarleeeserkeeeaerLkeeleeare 117
                 + ++ ++++ +e ++  ++L+e   +++++ e+L+ +  ++e+e++++  s++k+ ee +k  ++l+++e e++++e+e              ++e + 
  EFC38401.1 691 KHVQLMENQSKELKDYQNQLNEFELKMKKNHENLKIEILNLEKEKKQFSNSKSKKSEEISKKLQNLKQKEIEIEKMEKE--------------IKESKS 775
                 3333333333333333333444444444444555555555555555555555555555555555555555555555544..............444443 PP

         ERM 118 a 118
                 +
  EFC38401.1 776 K 776
                 3 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6  22.0      0.42   9.4e+02     144     259 ..     144     261 ..     132     268 .. 0.90
   2 ?   -0.8   0.4      0.25   5.6e+02     166     193 ..     312     339 ..     275     369 .. 0.55
   3 ?    7.8   7.4   0.00061       1.4     146     238 ..     410     493 ..     398     508 .. 0.53
   4 ?   15.2  20.0   3.4e-06    0.0076     143     228 ..     688     776 ..     682     784 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.42
        Spc7 144 leenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaei..eekkkelaelqeqleeleekieelk 240
                 ++ + +++e++++lL++q e+l+    e+e+ + e  ++le+++ ++e +e+    ++e  r+el++ ++ i  +e   +l +l++q+++ + k+e+  
  EFC38401.1 144 IQTIKSDMEKEQQLLKEQSEQLKFNQLEMERLERERIKKLEMERIEKERIEKECLLKIERERKELEKKQSFIitSETFSKLCSLNQQVDNNRRKVEKQF 242
                 577899*****************999999999999999999999999*****99************99988733455579999**************** PP

        Spc7 241 eqkseleeeiaeaervlee 259
                 e+++++ + i+ ++++++e
  EFC38401.1 243 ESIQSFSSSIQIKKEFQDE 261
                 ***********99988876 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.25
        Spc7 166 dellpeleeekaeleeeleklqeaaeel 193
                 +++l +l+++ + l+e+le  +e++ ++
  EFC38401.1 312 QKYLFKLQSYLEVLSEKLELFNEFNSQF 339
                 3344444444444444444444444333 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.00061
        Spc7 146 enlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekiee 238
                 +n+++l e+ +++++q+  +++ l+ l+   + l++el++ ++         ++e++ +++e++  + ++ e+k +l+e  ++l+e++ k+ +
  EFC38401.1 410 NNYSNLSEQFKTIQRQKTRITRNLNMLNLDIEGLKDELKHVNN---------EDEMNDIKDEIQIKEFNLIELKSNLKENIQKLNEIKMKFLQ 493
                 3445555555555555555555555555555555555555544.........55556666666666666666666666666655555555444 PP

  == domain 4  score: 15.2 bits;  conditional E-value: 3.4e-06
        Spc7 143 gleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesid...keeLeelreelaelkaeieekkkelaelqeq 228
                 +++++++ +e+++++L++ +++l+e+  ++++++++l+ e+ +l+++++++++++   +ee+ +  ++l++ + eie+ +ke++e +++
  EFC38401.1 688 KIQKHVQLMENQSKELKDYQNQLNEFELKMKKNHENLKIEILNLEKEKKQFSNSKskkSEEISKKLQNLKQKEIEIEKMEKEIKESKSK 776
                 579*************************************************9772124555555555566666677777777666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1030 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3524  (0.196553); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.10u 0.31s 00:00:01.41 Elapsed: 00:00:00.52
# Mc/sec: 5921.30
//
Query:       EFC38402.1  [L=364]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
   3.5e-118  394.8   7.5   4.3e-118  394.5   7.5    1.0  1  G-alpha    G-protein alpha subunit
    2.7e-16   59.5   1.7    2.9e-11   43.1   0.3    2.5  2  Arf        ADP-ribosylation factor family
    7.3e-06   25.5   0.9      0.039   13.3   0.2    2.3  2  Gtr1_RagA  Gtr1/RagA G protein conserved region
     0.0064   16.7   4.2        2.3    8.4   0.1    3.4  3  Roc        Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.012   15.7   0.0       0.95    9.6   0.0    2.5  2  MMR_HSR1   50S ribosome-binding GTPase
       0.12   12.1   0.0       0.28   10.9   0.0    1.6  1  AAA_29     P-loop containing region of AAA domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  394.5   7.5  1.5e-121  4.3e-118       2     354 .]      12     353 ..      11     353 .. 0.96

  Alignments for each domain:
  == domain 1  score: 394.5 bits;  conditional E-value: 1.5e-121
                 XXXXXXXXXXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCC CS
     G-alpha   2 rtssaidkslkaerkarkkkrevkllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldp 100
                 +++++i+++l ++++++k+  e+kllllG++eSGKsTi+kq+k+++ kg++ ee+  +++vi+ n+++si+ ++ea+++l++++  sf+++++ er+++
  EFC38402.1  12 TKNKEINAKLTRDNQKQKS--ELKLLLLGAGESGKSTIFKQMKIIHHKGYTPEECIRFKDVIYGNTLQSIRVLIEAMQTLNPQI--SFSNSSNIERAEK 106
                 57999********999999..***************************************************************..99*********** PP

                 CS-HCHHHH..........HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCGCCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT CS
     G-alpha 101 lkkveasliaklssateeeqeiefnpraevgedikaLwndpgiqelyerrnkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevd 199
                 +  + ++ i         +  + ++p  e+g+dik Lw+d giqe y+rr++++l+d+aey+l+d+er+ts++Y+pt++D+l++r+ktvGi e +f+++
  EFC38402.1 107 FTRIPEQQII-------LNAGSIISP--ELGKDIKLLWSDAGIQEAYRRRSEYQLNDSAEYYLRDIERLTSNNYQPTQQDVLRSRVKTVGIVEADFSIE 196
                 *999988653.......238889999..**********************************************************************9 PP

                 -TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGGCCTT- CS
     G-alpha 200 sklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgklskyfpsy 298
                  +++f+++dvgGqr+er+kW+++fddv+aiiF+++lse+dqvl+ed+ +nr+ esl+lF+eic+++++k+tp+i+f+nK D++eeK+k ++l k+fp+y
  EFC38402.1 197 -GYKFKMIDVGGQRNERRKWIHCFDDVTAIIFVAALSEYDQVLFEDKDMNRMIESLTLFTEICQSRYFKTTPLIIFFNKNDLFEEKIKVKDLDKCFPEY 294
                 .************************************************************************************************** PP

                 -H.CCHHHHHHHHHHHHHHCC....CCCCESGGSCEEEEEE-TT-HHHHHHHHHHHHHHH CS
     G-alpha 299 egrkndlesvlkylrnkFeei....hkeksnnrrkiythftsatdtkevqkviesvrdti 354
                 +g ++d+ ++ +y+ ++F++      +++s++ r++y h+t+atdt +++kv+++v+++i
  EFC38402.1 295 TG-GRDVGKARTYIMDQFISRagaaKSQSSKTGRQLYHHITCATDTGTMKKVLDDVKNSI 353
                 *9.****************98555455666999***********************9986 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.1   4.3e-06     0.013       8      57 ..      25      74 ..      18      79 .. 0.82
   2 !   43.1   0.3   9.8e-15   2.9e-11      38     130 ..     178     280 ..     170     295 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 4.3e-06
                GTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETT CS
         Arf  8 lklkkkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleikn 57
                 +++k el++lllG  ++GK+Ti k++k  + +  +P      +++ + n
  EFC38402.1 25 NQKQKSELKLLLLGAGESGKSTIFKQMKIIHHKGYTPEECIRFKDVIYGN 74
                455589**********************9999888888777777777665 PP

  == domain 2  score: 43.1 bits;  conditional E-value: 9.8e-15
                 SCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEE..........ETT-CTTHHHHHHHHHHHCTSGCCTTSEEEEEEE-TT CS
         Arf  38 elvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvv..........DsadreRleeakeeLkalleeeelkevallvlaNKqD 126
                  l + v T+g    + +i+++kf++ DvGGq++ R+ W + f++++a+ifv           +  d +R+ e+ + ++++ +++  k+ +l+++ NK D
  EFC38402.1 178 VLRSRVKTVGIVEADFSIEGYKFKMIDVGGQRNERRKWIHCFDDVTAIIFVAalseydqvlfEDKDMNRMIESLTLFTEICQSRYFKTTPLIIFFNKND 276
                 5556778999999999**********************************972222211111234677999999999999999**************** PP

                 STTS CS
         Arf 127 lpea 130
                 l e 
  EFC38402.1 277 LFEE 280
                 9654 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.6   0.0   8.8e-05      0.26       1      35 [.      33      71 ..      33     104 .. 0.80
   2 !   13.3   0.2   1.3e-05     0.039      33     131 ..     184     285 ..     163     300 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 8.8e-05
   Gtr1_RagA  1 kvLLmGksgsGKtsm...rsiiFd.nylardtlrlgati 35
                k+LL+G ++sGK+++    +ii++  y++++++r +  i
  EFC38402.1 33 KLLLLGAGESGKSTIfkqMKIIHHkGYTPEECIRFKDVI 71
                89************9444467865269999999987655 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 1.3e-05
   Gtr1_RagA  33 atidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDve........sreleedletlkeileal.rqyspeakvfvlihKmD 122
                  t+ + + ++   +  +++++D+gGq++   +       + f +v ++i+V   +        ++++++++e+l+   e   ++y +   + ++ +K D
  EFC38402.1 184 KTVGIVEADF-SIEGYKFKMIDVGGQRNERRK-----WIHCFDDVTAIIFVAALSeydqvlfeDKDMNRMIESLTLFTEICqSRYFKTTPLIIFFNKND 276
                 4666666667.456679*********987666.....589***********99988888888766788888777766665414688999999******* PP

   Gtr1_RagA 123 liqederee 131
                 l +e+ + +
  EFC38402.1 277 LFEEKIKVK 285
                 *99987755 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0    0.0013       3.9       1      19 [.      33      51 ..      33      71 .. 0.90
   2 !    8.4   0.1   0.00078       2.3      17      89 ..     164     240 ..     159     277 .. 0.52
   3 ?   -0.3   0.1      0.39   1.2e+03       6      40 ..     296     333 ..     294     351 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0013
                EEEEESSTTSSHHHHHHCH CS
         Roc  1 KvvlvGdsgvGKtsllkrf 19
                K++l+G +++GK++++k++
  EFC38402.1 33 KLLLLGAGESGKSTIFKQM 51
                89*************9986 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00078
                 HCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTT.T-HHHHCTSCEEEEEEE.........G CS
         Roc  17 krfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrs.lhplylreaalailvyd.........s 89 
                 +r+++++++++++  +   +     +++  ve d +++ +k+++ D++Gq + r    +++     ++i+v           +
  EFC38402.1 164 ERLTSNNYQPTQQDVLRSRV-----KTVGIVEADFSIEGYKFKMIDVGGQRNERRkWIHCFDDV-TAIIFVAAlseydqvlfE 240
                 55666666666555555555.....45555677888999***********87765155565554.455544332122133331 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.39
                 SSTTSSH..HHHHHCHCT-CCC.-EEETTTTEEEEEEE CS
         Roc   6 GdsgvGK..tsllkrfvedkfs.ekekstigvdfltke 40 
                 G   vGK  t ++++f+++    ++++s +g +++++ 
  EFC38402.1 296 GGRDVGKarTYIMDQFISRAGAaKSQSSKTGRQLYHHI 333
                 66778886688999999987651456667777776653 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0     0.021        62       3      19 ..      35      51 ..      33      89 .. 0.88
   2 ?    9.6   0.0   0.00032      0.95      31     114 .]     183     274 ..     163     274 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.021
                EEEESTTSSHHHHHHHH CS
    MMR_HSR1  3 aivGrpNvGKStLinal 19
                +++G   +GKSt+++++
  EFC38402.1 35 LLLGAGESGKSTIFKQM 51
                6899999*******987 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00032
                 TSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETTTTCSHH...HHHHHHHHHHH.............TTSEEEEEE CS
    MMR_HSR1  31 gtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdaseeklkp...ldeeleellee.............akkplilvl 112
                  +T  i+e+ ++++g +++++D+ G         ++++++    + + +i++v  +s e +++   +d+++++++e+             ++ pli+ +
  EFC38402.1 183 VKTVGIVEADFSIEGYKFKMIDVGG-QR------NERRKWIHCFDdVTAIIFVAALS-E-YDQvlfEDKDMNRMIESltlfteicqsryfKTTPLIIFF 272
                 567778888888999**********.33......44555554333388899999877.4.555222678888887657777777777777777777777 PP

                 ES CS
    MMR_HSR1 113 nk 114
                 nk
  EFC38402.1 273 NK 274
                 76 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   9.4e-05      0.28      23      39 ..      31      48 ..      19      55 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 9.4e-05
      AAA_29 23 g.atlltGpsGsGKSTll 39
                +   ll G+ +sGKST++
  EFC38402.1 31 ElKLLLLGAGESGKSTIF 48
                34689***********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (364 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       739  (0.0412181); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2227.51
//
Query:       EFC38403.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      3e-05   24.0   4.0      3e-05   24.0   4.0    2.3  2  Wtap             WTAP/Mum2p family
    3.3e-05   23.8   0.5    9.9e-05   22.3   0.5    1.9  1  SNARE            SNARE domain
    0.00013   21.8   0.0    0.00064   19.5   0.0    1.8  1  DUF885           Bacterial protein of unknown function (DUF88
    0.00029   21.3  20.0     0.0054   17.3   6.0    2.5  2  APG6_N           Apg6 coiled-coil region
     0.0045   15.8   0.3     0.0045   15.8   0.3    2.1  1  DUF2207          Predicted membrane protein (DUF2207)
     0.0055   16.7   4.9       0.17   11.8   0.1    3.3  3  TarH             Tar ligand binding domain homologue
  ------ inclusion threshold ------
      0.012   15.4  13.4       0.63    9.8   0.2    3.3  3  SKA2             Spindle and kinetochore-associated protein 2
      0.035   14.8   3.4        1.9    9.2   0.3    2.9  2  Sulfatase_C      C-terminal region of aryl-sulfatase
      0.052   13.6  17.8       0.21   11.6   3.0    3.6  3  DUF1664          Protein of unknown function (DUF1664)
      0.053   13.4   0.2      0.053   13.4   0.2    4.0  4  Sec20            Sec20
      0.075   11.9   0.2      0.075   11.9   0.2    1.7  2  DUF1729          Domain of unknown function (DUF1729)
      0.088   12.8   2.4         11    6.0   0.1    2.9  3  CYTL1            Cytokine-like protein 1
      0.096   12.6   0.8       0.48   10.3   0.1    2.3  2  DUF2721          Protein of unknown function (DUF2721)
       0.12   11.6  16.1      0.069   12.4   5.0    2.6  2  TMPIT            TMPIT-like protein
       0.19   12.1   4.9      0.097   13.0   2.1    2.0  1  V-SNARE_C        Snare region anchored in the vesicle membran
       0.25   11.6   5.7         15    5.9   0.7    3.8  3  DUF948           Bacterial protein of unknown function (DUF94
       0.25   11.2   6.7       0.14   12.0   0.5    2.5  2  DUF1465          Protein of unknown function (DUF1465)
       0.48   10.8  13.7       0.25   11.6   0.9    3.7  3  BLOC1_2          Biogenesis of lysosome-related organelles co
        0.5    9.8  12.7       0.61    9.6   3.8    2.6  3  FAP206           Domain of unknown function
        0.6   10.0   4.2       0.31   10.9   0.3    2.4  2  Hypoth_Ymh       Protein of unknown function (Hypoth_ymh)
       0.74   10.3  14.7        0.9   10.0   3.9    3.4  3  Snapin_Pallidin  Snapin/Pallidin
       0.81    9.7  13.5       0.19   11.7   2.1    3.1  2  Laminin_II       Laminin Domain II
       0.87    8.4  26.1          1    8.2   8.9    2.5  2  Spc7             Spc7 kinetochore protein
       0.92    9.4  21.9       0.22   11.4   3.6    3.5  3  Sec34            Sec34-like family
        1.3    9.3  14.3        1.3    9.3   3.6    3.2  3  KxDL             Uncharacterized conserved protein
        1.9    6.7   5.6       0.44    8.8   2.1    1.6  2  SpecificRecomb   Site-specific recombinase
        2.2    9.0  13.2        1.4    9.7   1.2    3.2  4  DUF2203          Uncharacterized conserved protein (DUF2203)
        2.7    8.7   8.3        7.6    7.2   0.0    3.4  2  SlyX             SlyX
        3.3    8.1  20.4        4.6    7.7   4.4    3.4  3  CENP-H           Centromere protein H (CENP-H)
        5.4    7.2  22.8       0.11   12.7   5.4    2.9  2  Jnk-SapK_ap_N    JNK_SAPK-associated protein-1
          6    7.2   8.0        3.7    7.9   1.7    2.7  2  DUF2935          Domain of unknown function (DUF2935)
        6.1    7.6  11.5        1.9    9.2   0.7    3.4  3  Plk4_PB2         Polo-like Kinase 4 Polo Box 2
          8    6.8  16.0        4.2    7.8   0.5    3.4  3  YlqD             YlqD protein
        8.2    6.9  25.5       0.19   12.1   7.6    3.5  3  Syntaxin_2       Syntaxin-like protein
        9.9    6.7  17.0        5.6    7.5   0.2    4.0  4  Spectrin         Spectrin repeat


Domain annotation for each model (and alignments):
>> Wtap  WTAP/Mum2p family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   4.0   5.9e-08     3e-05      55     144 ..       7     108 ..       4     119 .. 0.89
   2 ?   -0.6   0.7       2.3   1.2e+03     129     129 ..     250     250 ..     185     285 .. 0.62

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 5.9e-08
        Wtap  55 fsrlrkeleeaenkleeaqeeLqalkftpds.............qtGkrLmakcrvLeqENeELgkvleegrvakLeselalqkkfveelkkaleelee 140
                 +s+ ++ele++e+k+ee+  +L++l+ t +s             +t  +L++kcr+L+++ ++L + ++     +++  ++++k+++++l+ + ++++ 
  EFC38403.1   7 LSTYTHELESVESKIEENITTLRRLNITNQSdpnfissqistlsETIEELLEKCRKLYNKINNL-TKNDPSVENQVSDTKKKHKEIIAKLRASYKQSKT 104
                 567799************************66666666666666********************.7788888899***********************9 PP

        Wtap 141 llee 144
                 ++e 
  EFC38403.1 105 FIET 108
                 9985 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 2.3
        Wtap 129 e 129
                 +
  EFC38403.1 250 D 250
                 1 PP

>> SNARE  SNARE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.5   1.9e-07   9.9e-05       2      49 ..     251     298 ..     250     302 .. 0.95

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 1.9e-07
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTXXXXXXXXXXXXXXXX CS
       SNARE   2 mvDrIdtnVenaqsnveraqkeLkkavkyqksnRklkciillilviil 49 
                 ++ rId +++   snv+raqke+  ++++ +    + +++ll+++ il
  EFC38403.1 251 QLRRIDEEMDALGSNVKRAQKEITSFMRRIQTDKCCAVLCLLVALAIL 298
                 789****************************************99998 PP

>> DUF885  Bacterial protein of unknown function (DUF885)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.0   1.2e-06   0.00064     143     304 ..      51     281 ..       2     288 .. 0.43

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 1.2e-06
                 HHHHHHHGTSSHHCCCHH.CCCCCC..........HHHHHHHHHH.HHHHHHHHHHHHHHHHHCC.................................. CS
      DUF885 143 eqlrgllagaaaeasalvaplaele......aek.ealraeleaalaeavkpayaeladfleeel.................................. 200
                 e +++ll    ++  +l++++++l+      +++ ++ +++++++  +++++ y++   f+e++                                   
  EFC38403.1  51 ETIEELL----EKCRKLYNKINNLTkndpsvENQvSDTKKKHKEI-IAKLRASYKQSKTFIETKAkglndgkssnnsalestnsnltsnssssatnsgg 144
                 2222222....2233344444444444444433323444444444.55555555555555555555555555555555555555555555555555555 PP

                 ...............................HHHS-BSS..HHHHHHHHHHHHHSSSS-HHHHHHHHHHHHHHHHHHHHHHHHHH.HH.-.HHHHHHHH CS
      DUF885 201 ...............................lpaarkdapdGeelYarllrsftttdltpeeihelglaelariraemeaiakev.gf.kgdlaevlaa 266
                                                 +++  da d +  Y+  ++ + ++    +ei +   +e+ ++++e   i++++ ++ ++++a + ++
  EFC38403.1 145 vrkkegfftfanklnegknssnaieeddvveVKRNS-DA-DVTNMYKGNANLTQEQRQRHDEIEKELFSEVFSTQKECLDIIDRLnKKsEETIALATDS 241
                 555555555555555555555555544443211111.22.45555555555555555555555555555555555555555555522222333333333 PP

                 HC..H-GGGEEESHHHHHHHHHHHHHHHHHHHCCHHHCCT CS
      DUF885 267 lr..tdprfyleetdagreellaaaraaiaeldaklpehf 304
                  +  +++r +l+  d+  ++l + +++a++e+  ++++ +
  EFC38403.1 242 ADllRQQRDQLRRIDEEMDALGSNVKRAQKEITSFMRRIQ 281
                 3333333333344444444444444444444444444332 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   6.0     1e-05    0.0054      11     127 ..       7     125 ..       5     131 .. 0.82
   2 !    9.6   6.0    0.0024       1.2      25     130 ..     148     270 ..     144     281 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1e-05
      APG6_N  11 leeldkqleqaekerdaYeeflkklkkekkeeek.qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreynel 108
                 l++++++le++e+++++  + l++l+ +++++ +   +++  l e +e+l ++ ++l +++++l k++ ++e+++++ +++++++ ++ ++  ++ + +
  EFC38403.1   7 LSTYTHELESVESKIEENITTLRRLNITNQSDPNfISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQSKTF 105
                 56789999999************999765554337899***********************************************99999999999996 PP

      APG6_N 109 qlelleleeeldsl.eaqye 127
                   ++++  ++ +s  ++++e
  EFC38403.1 106 IETKAKGLNDGKSSnNSALE 125
                 66555555555544044455 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0024
      APG6_N  25 rdaYeeflkklkkekkeeek....................qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwr 103
                 ++ + +f +kl++ k+++++                     + + + ++e+ ++ ++ e+el++e   ++ke  ++ + l++ +ee+ al  + +  +r
  EFC38403.1 148 KEGFFTFANKLNEGKNSSNAieeddvvevkrnsdadvtnmYKGNANLTQEQRQRHDEIEKELFSEVFSTQKECLDIIDRLNKKSEETIALATDSADLLR 246
                 56667788888888777766888888888888888888866666666677777788889***************************************9 PP

      APG6_N 104 eynelqlelleleeeldsleaqyehaq 130
                 ++++   +l + +ee+d+l ++++ aq
  EFC38403.1 247 QQRD---QLRRIDEEMDALGSNVKRAQ 270
                 9887...55566666666666666665 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.3   8.8e-06    0.0045     303     406 ..     183     308 ..     156     325 .. 0.65

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 8.8e-06
     DUF2207 303 d.......tltilkkndeeldpyEkalldlLfdkseeg.ks....lkeikkyakkskk..............kakkfkkalkkwksavkk...kergyf 372
                 d       +  +++++ +  d++Ek+l++  f++++e+ +          k+++++ +                +++ ++++++ s+vk+   +   ++
  EFC38403.1 183 DvtnmykgNANLTQEQRQRHDEIEKELFSEVFSTQKEClDIidrlN----KKSEETIAlatdsadllrqqrdQLRRIDEEMDALGSNVKRaqkEITSFM 277
                 03444444446777777777************99999988855552....4444443355557787777777889999999999999999554444444 PP

     DUF2207 373 dkkgkkklkklsalglgliilglilillallllv 406
                 +   + ++ k +a++ +l+ l++++++++++++ 
  EFC38403.1 278 R---RIQTDKCCAVLCLLVALAILGGCIFAIVMK 308
                 4...445555566666666666666555555554 PP

>> TarH  Tar ligand binding domain homologue
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.1   0.00033      0.17      51     134 ..      11      97 ..       2     105 .. 0.87
   2 ?    3.6   0.3      0.11        56      50      95 ..     234     274 ..     210     279 .. 0.76
   3 ?    1.3   0.0      0.54   2.8e+02      14      46 ..     288     325 ..     286     335 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00033
                 HHHHHHHHHHHHHHHHHHHHHHHHHTTTSSSSS......SHHHHHHHHHHHHHHHHHHHHHTS---GGGHH.HHHHHHHHHHHHHHHHHH CS
        TarH  51 qaaLaearvsllqaRltLnragiaaladeaeda......kellaraeeslaqseeawkaYlalprtaeeeealaaelkakykalqdglap 134
                 +++L +++++  ++ +tL r     + +++++       ++l +++ee+l++  + +++  +l+++++  e+  +++k+k k++ + l++
  EFC38403.1  11 THELESVESKIEENITTLRR---LNITNQSDPNfissqiSTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRA 97 
                 688999999999********...6666666666667999*******************************************98888876 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.11
                 HHHHHHHHHHHHHHHHHHHHHHHHHHTTTSSSSSSHHHHHHHHHHH CS
        TarH  50 qqaaLaearvsllqaRltLnragiaaladeaedakellaraeesla 95 
                  +a  +++ + l q+R++L r     ++ e++   ++++ra++ ++
  EFC38403.1 234 TIALATDSADLLRQQRDQLRR-----IDEEMDALGSNVKRAQKEIT 274
                 4445568999999********.....66666666999999998875 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.54
                 XXXXXXXXXXXXXSSSSSSHH.....HHHHHCHHHHHH CS
        TarH  14 vlallgvLllvsgglglsgls.....rsndalrevytn 46 
                 vl ll++L ++ g ++ + ++     ++n++ ++ ++n
  EFC38403.1 288 VLCLLVALAILGGCIFAIVMKfvplpNNNNNNNNNNNN 325
                 77888888888888887777533333333333333333 PP

>> SKA2  Spindle and kinetochore-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.2    0.0012      0.63      11      66 ..       7      65 ..       2      70 .. 0.89
   2 ?    7.4   0.3    0.0073       3.7      41      87 ..      61     107 ..      59     128 .. 0.89
   3 ?    8.0   3.0    0.0045       2.3      12      93 ..     188     273 ..     181     287 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.0012
        SKA2 11 FqkaesdLdyvqhrLekefqqsypdna...eNpvkLlerlkkvkeelqaLkeqceella 66
                + + +++L+ v+++ e+ + +  + n     +p  + ++++ + e +++L e+c++l++
  EFC38403.1  7 LSTYTHELESVESKIEENITTLRRLNItnqSDPNFISSQISTLSETIEELLEKCRKLYN 65
                667789*************9999888888899***********************9986 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0073
        SKA2  41 vkLlerlkkvkeelqaLkeqceellaekkelidkirttlvanrellq 87 
                 +kL ++++++++  +++++q+ +  ++ ke+i k+r++  + +++++
  EFC38403.1  61 RKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQSKTFIE 107
                 6899*********************************9988877765 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0045
        SKA2  12 qkaesdLdyvqhrLekefqqsypdna....eNpvkLlerlkkvkeelqaLkeqceellaekkelidkirttlvanrellqqLqasa 93 
                 +k ++ L+  q++  +e+++++  +     ++ + ++ rl+k  ee  aL ++  +ll ++++  ++i   + a  + +++ q+++
  EFC38403.1 188 YKGNANLTQEQRQRHDEIEKELFSEVfstqKECLDIIDRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEI 273
                 56677777777777777777777776777789************************************999998888888888776 PP

>> Sulfatase_C  C-terminal region of aryl-sulfatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.3    0.0037       1.9      60     113 ..      72     125 ..      33     136 .. 0.90
   2 ?    5.4   0.1     0.058        30      64     117 ..     232     287 ..     223     292 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0037
                  TT-TT--S-TTSTTCCHHHHHHHHHHHHHHHCCC------TCCHHCHS.-GGGS CS
  Sulfatase_C  60 erDpsEkyplsaespeykevlkeikkaveehkktlkpvpnqlakgellpkpwlq 113
                  ++Dps ++++s +++++ke+++++++ +++ k  ++   + l+ g+++++ +l+
   EFC38403.1  72 KNDPSVENQVSDTKKKHKEIIAKLRASYKQSKTFIETKAKGLNDGKSSNNSALE 125
                  58*********999*********************9999999999777666554 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.058
                  T--S-TTSTT....CCHHHHHHHHHHHHHHHCCC------TCCHHCHS.-GGGS--ST CS
  Sulfatase_C  64 sEkyplsaes....peykevlkeikkaveehkktlkpvpnqlakgellpkpwlqpcce 117
                  +E+  l+++s    ++ ++ l++i ++++++ +++k ++++++++  + +  + +cc 
   EFC38403.1 232 EETIALATDSadllRQQRDQLRRIDEEMDALGSNVKRAQKEITSF--MRRIQTDKCCA 287
                  566666666666778899999*********************999..77999999993 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.3      0.03        15      67     121 ..       3      57 ..       1      60 [. 0.88
   2 ?    5.7   0.9     0.028        14      37      87 ..      61     111 ..      58     133 .. 0.85
   3 ?   11.6   3.0   0.00042      0.21      36     119 ..     191     275 ..     180     280 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.03
     DUF1664  67 ridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveglesklerie 121
                  ++++ +   e + + ++i+e++t++r+   + ++d + +++ +++l +++e++ 
  EFC38403.1   3 SLEKLSTYTHELESVESKIEENITTLRRLNITNQSDPNFISSQISTLSETIEELL 57 
                 6778888889999999***********999999999************9999985 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.028
     DUF1664  37 rslsdavesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeike 87 
                 r l + +++++k+  +v +++++tk++ ++ i+++ ++ +++k  ++  ++
  EFC38403.1  61 RKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQSKTFIETKAK 111
                 678899999****9*********************9999999888776555 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 0.00042
     DUF1664  36 krslsdavesvskqle.qvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeavegleskler 119
                 + +l++   +   ++e ++ +++ +t+++  + idr++kk +e+++++++ ++ + + r++l++i+e+++++ + v+  ++++++
  EFC38403.1 191 NANLTQEQRQRHDEIEkELFSEVFSTQKECLDIIDRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEITS 275
                 5555555555556665246789999999999******************************************999998888876 PP

>> Sec20  Sec20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1       2.1   1.1e+03      28      53 ..       4      29 ..       2      36 .. 0.79
   2 ?    1.7   1.0      0.47   2.4e+02      17      70 ..      49     103 ..      37     109 .. 0.62
   3 ?   -1.3   0.1         4   2.1e+03      40      66 ..     146     172 ..     111     177 .. 0.62
   4 ?   13.4   0.2    0.0001     0.053      16      90 ..     230     308 ..     215     310 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 2.1
       Sec20 28 leeldastkslekleeeykqvedvls 53
                le+l++ t++le++e++  +  ++l+
  EFC38403.1  4 LEKLSTYTHELESVESKIEENITTLR 29
                78999999999999998877666665 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.47
       Sec20  17 lsqevqqSeenleeldastkslekleeey.kqvedvlsrskklvkklerrdktdk 70 
                 ls+++++  e   +l ++ ++l+k +     qv+d+ ++ k+++ kl  + k+ k
  EFC38403.1  49 LSETIEELLEKCRKLYNKINNLTKNDPSVeNQVSDTKKKHKEIIAKLRASYKQSK 103
                 5555555555566666666666666554424667777777777777776666655 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 4
       Sec20  40 kleeeykqvedvlsrskklvkklerrd 66 
                 + +e+++ +++ l+ +k+  + +e+ d
  EFC38403.1 146 RKKEGFFTFANKLNEGKNSSNAIEEDD 172
                 345777777777777777666665555 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 0.0001
       Sec20  16 llsqevqqSeenleeldastkslekleeeykqvedvlsrskklvkklerrdktdkll....vflalglflacvvyvvkk 90 
                    +++   +  ++ l+++  +l +++ee   + + ++r++k ++++ rr +tdk      +++al+++  c++ +v+k
  EFC38403.1 230 KSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEITSFMRRIQTDKCCavlcLLVALAILGGCIFAIVMK 308
                 556778888889999***************************************9751111556777777788777776 PP

>> DUF1729  Domain of unknown function (DUF1729)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.2   0.00015     0.075     119     177 ..      44     102 ..      33     117 .. 0.86
   2 ?   -1.7   0.1         2     1e+03     117     173 ..     173     230 ..     162     266 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00015
     DUF1729 119 svrSelgepihkianraaklwkeldetifsleavekrkaalekkrdeiierlnkdyakp 177
                 s  S l e i ++  ++ kl++++++   + ++ve+++   +kk++eii++l + y++ 
  EFC38403.1  44 SQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQS 102
                 67899*************************************************99754 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 2
     DUF1729 117 vvsvrSelgepihkianraaklwkeldetifsleavekrkaalekkrd..eiierlnkd 173
                 vv v+ +  +++ ++    a+l +e  ++  ++ ++e  + +++++++   ii+rlnk 
  EFC38403.1 173 VVEVKRNSDADVTNMYKGNANLTQEQRQRHDEI-EKELFSEVFSTQKEclDIIDRLNKK 230
                 555555555566666666666666655555555.3444444444444422467777765 PP

>> CYTL1  Cytokine-like protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0      0.03        16      70     104 ..      40      74 ..      26      98 .. 0.89
   2 ?   -1.4   0.0       4.1   2.1e+03      22      44 ..     210     232 ..     206     239 .. 0.77
   3 ?    6.0   0.1     0.021        11      28      81 ..     269     319 ..     261     335 .. 0.72

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.03
       CYTL1  70 dflaspkcrkvarvealkekvrklytiinkvcrrd 104
                 +f++s+  +    +e+l ek rkly+ in++ + d
  EFC38403.1  40 NFISSQISTLSETIEELLEKCRKLYNKINNLTKND 74 
                 577888888888999*************9998877 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 4.1
       CYTL1  22 ysrvlslskeitesleklqkser 44 
                 +s v+s  ke  + +++l+k ++
  EFC38403.1 210 FSEVFSTQKECLDIIDRLNKKSE 232
                 68888888999999888887655 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.021
       CYTL1  28 lskeitesleklqksertescvevlPkl.yldihnscvlaklrdflaspkcrkva 81 
                   keit+ ++++q+    ++c  vl  l  l i   c+ a +  f++ p+ ++  
  EFC38403.1 269 AQKEITSFMRRIQT----DKCCAVLCLLvALAILGGCIFAIVMKFVPLPNNNNNN 319
                 56888888888775....5666677655279***************877655544 PP

>> DUF2721  Protein of unknown function (DUF2721)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       2.1   1.1e+03      14      54 ..      45      82 ..      41      98 .. 0.66
   2 ?   10.3   0.1   0.00094      0.48      27      86 ..     250     307 ..     220     316 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 2.1
     DUF2721 14 lllvltnRlariadrirqLedeleelaeeeeedeelakeik 54
                 +++l+  +  + ++ r+L +++++l++++    +++++++
  EFC38403.1 45 QISTLSETIEELLEKCRKLYNKINNLTKND---PSVENQVS 82
                556666666777778888888888777774...34555554 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00094
     DUF2721  27 drirqLedeleelaeeeeedeelakeiknlrrRarlirrailllv.lsallvvlvvlllfl 86 
                 d++r++ +e+++l ++    ++ +kei ++ rR++  + + +l+  ++++++  +++++++
  EFC38403.1 250 DQLRRIDEEMDALGSN---VKRAQKEITSFMRRIQTDKCCAVLCLlVALAILGGCIFAIVM 307
                 5556666666655555...346788899999999988876655551556666677777776 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   5.0   0.00013     0.069       3      93 ..      45     135 ..      43     144 .. 0.93
   2 ?    4.6   2.7     0.032        16       6      70 ..     212     275 ..     189     288 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00013
       TMPIT   3 eweelekefkeleetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelkerkkvlkevesllpkkn 93 
                 ++++l++ ++el e+ +++ +k+++l+k   ++ ++++  kk+ ke+ ++l+   k++k+  e++++ l++  ++ ++ l++++s l++++
  EFC38403.1  45 QISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQSKTFIETKAKGLNDGKSSNNSALESTNSNLTSNS 135
                 67899************************************************9999999999999*****99999999999999999874 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.032
       TMPIT   6 elekefkeleetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeevee 70 
                 e+ + +ke+ +  +++++k+ee+ +l ++ +  +++q+ +l++++++++ l ++vk+ ++ e+++
  EFC38403.1 212 EVFSTQKECLDIIDRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQK-EITS 275
                 344445555556666666777777777777777777777777777777777666653333.3333 PP

>> V-SNARE_C  Snare region anchored in the vesicle membrane C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   2.1   0.00019     0.097      18      65 ..     232     279 ..     222     280 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 0.00019
   V-SNARE_C  18 detisiGaailedLhsQretLkrarsklhnvanrlgksnsiLrsikrR 65 
                 +eti+ ++   + L++Qr++L+r+ + +  ++++++++++ ++s +rR
  EFC38403.1 232 EETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEITSFMRR 279
                 7999999999999******************************99999 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.7      0.03        15      40      75 ..      44      72 ..       4     115 .. 0.61
   2 ?    5.0   0.3     0.056        28      43      84 ..     225     266 ..     191     276 .. 0.53
   3 ?    0.0   0.0         2     1e+03       4      20 ..     291     307 ..     287     332 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.03
      DUF948 40 kqvdpilkevedllakvnelledvneklekvdplte 75
                +q+  +++ +e+ll+k ++l + +n       +lt+
  EFC38403.1 44 SQISTLSETIEELLEKCRKLYNKIN-------NLTK 72
                3333333333333333333333333.......2222 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.056
      DUF948  43 dpilkevedllakvnelledvneklekvdplteavadlgesv 84 
                 d + k++e+++a + + ++ ++++ +++ ++ e++  lg +v
  EFC38403.1 225 DRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNV 266
                 333333333333333333333333333333333333333333 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 2
      DUF948   4 lIaAiAFvvLviflivv 20 
                 l++A+A++  +if iv+
  EFC38403.1 291 LLVALAILGGCIFAIVM 307
                 67888888888888876 PP

>> DUF1465  Protein of unknown function (DUF1465)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.5   0.00027      0.14      90     151 ..      33      96 ..      15     101 .. 0.72
   2 ?    1.9   1.1      0.35   1.8e+02     105     151 ..     231     281 ..     185     283 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00027
                 ---....-----------HHHHHHHHHHHHHHHHHHHHHHHHHT-SSXXXX.XXXXXXXXXXXX CS
     DUF1465  90 laaae..asdaeavaeLpeelqeLierserLyervrrLdrelreeaeaaeaaenpvaeqlerLe 151
                  ++++  +  ++++++L e+++eL+e+ ++Ly+++ +L ++    +++ + ++++ +e +++L+
  EFC38403.1  33 ITNQSdpNFISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLR 96 
                 44433235567899************************88766655555555555555565555 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.35
                 -HHHHHHHHHHHHH....HHHHHHHHHHHHT-SSXXXX.XXXXXXXXXXXX CS
     DUF1465 105 peelqeLierserL....yervrrLdrelreeaeaaeaaenpvaeqlerLe 151
                  ee+ +L + s +L     +++rr+d+e+ +  ++ ++a++++++ ++r++
  EFC38403.1 231 SEETIALATDSADLlrqqRDQLRRIDEEMDALGSNVKRAQKEITSFMRRIQ 281
                 344445555555552222357899999999999998888999999888887 PP

>> BLOC1_2  Biogenesis of lysosome-related organelles complex-1 subunit 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   1.6      0.16        81      69      95 ..      41      67 ..       1      70 [. 0.51
   2 ?    4.3   1.1     0.096        49       6      26 ..      48      68 ..      37     108 .. 0.47
   3 ?   11.6   0.9    0.0005      0.25      17      79 ..     216     278 ..     203     282 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.16
     BLOC1_2 69 qiekqvteLeeavseLDeyskeLEakf 95
                 i  q+++L e+++eL e +++L +k+
  EFC38403.1 41 FISSQISTLSETIEELLEKCRKLYNKI 67
                245566666666666655555555554 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.096
     BLOC1_2  6 kvskyleaeleatvedyklLe 26
                ++s+ +e+ le  ++ y+ ++
  EFC38403.1 48 TLSETIEELLEKCRKLYNKIN 68
                222222222222222222222 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 0.0005
     BLOC1_2  17 atvedyklLeklNeaasekykklkdvaaslekkleklnekyeelqpylqqidqiekqvteLee 79 
                   +e ++++ +lN++++e ++  +d+a+ l+++ ++l++ +ee++ + +++++ +k++t++  
  EFC38403.1 216 TQKECLDIIDRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEITSFMR 278
                 455668999*************************************************99865 PP

>> FAP206  Domain of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   1.6      0.04        20       4      38 ..      44      80 ..       4     110 .. 0.62
   2 ?    5.3   1.0     0.024        12       4      66 ..      44     108 ..      41     133 .. 0.68
   3 ?    9.6   3.8    0.0012      0.61       2      93 ..     194     281 ..     193     283 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.04
      FAP206  4 eaipatreaiekeleeaqelasrytallekl..vees 38
                 +i++++e+ie+ le++++l ++ + l ++   ve++
  EFC38403.1 44 SQISTLSETIEELLEKCRKLYNKINNLTKNDpsVENQ 80
                3455555555555555555555555555444443333 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.024
      FAP206   4 eaipatreaiekeleeaqelasrytallekl..veeseaevaeeqlerlkqalinvrqyeaylri 66 
                  +i++++e+ie+ le++++l ++ + l ++   ve++ +++++++ e + +  + + q + ++++
  EFC38403.1  44 SQISTLSETIEELLEKCRKLYNKINNLTKNDpsVENQVSDTKKKHKEIIAKLRASYKQSKTFIET 108
                 56778888888888888888888877777766655555566666666666666666666666665 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.0012
      FAP206   2 Leeaipatreaiekeleeaqelasrytalleklveeseaevaeeqlerlkqalinvrqyeaylrilledveksaeeveellkrfeaeleklk 93 
                 L +++++  ++iekel    e+ s++++ l+ +  ++ ++++ee +++ ++    +rq+  +lr + e+++ + ++v++ +k+  + ++ ++
  EFC38403.1 194 LTQEQRQRHDEIEKELF--SEVFSTQKECLDII--DRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEITSFMRRIQ 281
                 55677888888999887..89999999999999..9999*********************************************99999887 PP

>> Hypoth_Ymh  Protein of unknown function (Hypoth_ymh)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.4       1.8   9.3e+02       7      17 ..      91     101 ..      47     156 .. 0.64
   2 ?   10.9   0.3    0.0006      0.31      27      71 ..     187     233 ..     175     262 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 1.8
  Hypoth_Ymh   7 ilkaarkella 17 
                 i+++ r+ +++
  EFC38403.1  91 IIAKLRASYKQ 101
                 33333333332 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.0006
  Hypoth_Ymh  27 Aikaledrvreksgltkd.gkeLmqeafsakkplla.indlstetek 71 
                   k+ ++ ++e  +++++ +keL++e+fs++k+ l+ i +l++++e+
  EFC38403.1 187 MYKGNANLTQEQRQRHDEiEKELFSEVFSTQKECLDiIDRLNKKSEE 233
                 5666677788888888559*************999956888877776 PP

>> Snapin_Pallidin  Snapin/Pallidin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1       1.8   9.3e+02      62      80 ..       4      22 ..       1      38 [. 0.67
   2 ?    5.6   0.6      0.04        21      20      63 ..      44      89 ..      39     110 .. 0.60
   3 ?   10.0   3.9    0.0018       0.9      22      87 ..     210     274 ..     192     277 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 1.8
  Snapin_Pallidin 62 akKLvnikkrmsslnerlq 80
                     ++KL++  ++++s++++++
       EFC38403.1  4 LEKLSTYTHELESVESKIE 22
                     4666777777777666654 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.04
  Snapin_Pallidin 20 eklkelrqsQeeLleqldrlnekLkeleeaqe..aevlpdlkeyak 63
                     ++++ l ++ eeLle++++l +k+++l ++++  +++++d+k+ +k
       EFC38403.1 44 SQISTLSETIEELLEKCRKLYNKINNLTKNDPsvENQVSDTKKKHK 89
                     4566666666666666666666666666666633333334333333 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.0018
  Snapin_Pallidin  22 lkelrqsQeeLleqldrlnekLkeleeaqeaevlpdlkeyakKLvnikkrmsslnerlqklkkRae 87 
                      ++e+  +Q+e l+ +drln+k +e+  ++  ++   l++ ++ L++i  +m +l + +++++k ++
       EFC38403.1 210 FSEVFSTQKECLDIIDRLNKKSEETIALAT-DSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEIT 274
                      578999*****************9999998.899****************************9876 PP

>> Laminin_II  Laminin Domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   2.1   0.00038      0.19      20      77 ..      40      97 ..      31     105 .. 0.90
   2 ?    4.3   1.4     0.076        39      31      77 ..     222     268 ..     189     282 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00038
                XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHH CS
  Laminin_II 20 aplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklke 77
                + +s +++ ++e ++e+ ++ ++  +k+++++k   +++++v++ +k+  ++++kl+ 
  EFC38403.1 40 NFISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRA 97
                56899**************************************************986 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.076
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHH CS
  Laminin_II  31 eklseinrsveetnekvkdankairdArrsvkkLeklapqLldklke 77 
                 + + ++n++ eet +++ d+   +r+ r++ + ++++++ L + +k+
  EFC38403.1 222 DIIDRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKR 268
                 33455555555555555555555555555555555555555444333 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   8.9     0.002         1     162     261 ..       4     103 ..       1     138 [. 0.55
   2 ?    6.0   8.6    0.0089       4.5     140     237 ..     176     281 ..     170     285 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.002
        Spc7 162 eeeldellpeleeekaeleeeleklqe...aaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeaervl 257
                  e+l+++ +ele+ ++++ee++++l++    +++  +  + ++ +l e+++el ++ +++ +++++l+++  ++e++++++k++ +e+ ++++++ +  
  EFC38403.1   4 LEKLSTYTHELESVESKIEENITTLRRlniTNQSDPNFISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYK-- 100
                 5666666677777777777777777663322222222335566666666666666666666666666666666666666665554444444443333.. PP

        Spc7 258 eeck 261
                  + k
  EFC38403.1 101 -QSK 103
                 .222 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0089
        Spc7 140 LkegleenlegleedkelLekqeeel.dellpeleeekaeleeeleklqeaaeeles......id.keeLeelreelaelkaeieekkkelaelqeqle 230
                 +k + +  ++++ + +++L++++ +  de+ +el +e  + ++e  ++ ++ ++ ++       d  + L++ r++l+++++e++++  ++++ q++++
  EFC38403.1 176 VKRNSDADVTNMYKGNANLTQEQRQRhDEIEKELFSEVFSTQKECLDIIDRLNKKSEetialaTDsADLLRQQRDQLRRIDEEMDALGSNVKRAQKEIT 274
                 5666677778888888888765544437788888777777777755544432222222333554449999**************************999 PP

        Spc7 231 eleekie 237
                 +   +i+
  EFC38403.1 275 SFMRRIQ 281
                 8877776 PP

>> Sec34  Sec34-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   3.6   0.00044      0.22       2      66 ..       4      72 ..       3      74 .. 0.85
   2 ?    2.4   1.9      0.25   1.3e+02      15      49 ..      77     111 ..      64     161 .. 0.56
   3 ?    6.4   2.7     0.015       7.6       4      62 ..     198     257 ..     195     282 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00044
       Sec34  2 ldqLeskeeecdelleqtdealeqLeel....eekfksvsektsslheaceqlleeqkrleelaeeiee 66
                l++L++++ e++++ ++++e  ++L+ l    +++ +++s++ s+l+e+ e+lle+ ++l +  +++++
  EFC38403.1  4 LEKLSTYTHELESVESKIEENITTLRRLnitnQSDPNFISSQISTLSETIEELLEKCRKLYNKINNLTK 72
                68999**************9999999882222355689*********************9998887765 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.25
       Sec34  15 lleqtdealeqLeeleekfksvsektsslheaceq 49 
                 + +q+++++++ +e+  k ++  ++++++ e+  +
  EFC38403.1  77 VENQVSDTKKKHKEIIAKLRASYKQSKTFIETKAK 111
                 33455555555555555555555555555443332 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.015
       Sec34   4 qLeskeeecdelleqtdealeqLeeleekfksvsektsslheaceqlleeqk.rleelae 62 
                 q +++ e  +el++++ +++++  ++ ++ ++ se+t +l +++ +ll++q+ +l+++ e
  EFC38403.1 198 QRQRHDEIEKELFSEVFSTQKECLDIIDRLNKKSEETIALATDSADLLRQQRdQLRRIDE 257
                 66778888899*************************************998724555554 PP

>> KxDL  Uncharacterized conserved protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       6.1   3.1e+03      41      54 ..      12      25 ..       3      32 .. 0.46
   2 ?    4.6   2.1     0.076        39      30      82 ..      47      99 ..      26     102 .. 0.89
   3 ?    9.3   3.6    0.0026       1.3       7      80 ..     206     282 ..     202     284 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 6.1
        KxDL 41 erlaklrarfkqgt 54
                ++l+++++++++++
  EFC38403.1 12 HELESVESKIEENI 25
                33344444444444 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.076
        KxDL 30 reLlelnalsqerlaklrarfkqgtkllkevkkdLesifkkirslkaklakky 82
                 +L+e ++++ e+  kl +++++ tk   +v ++   ++kk + + akl++ y
  EFC38403.1 47 STLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASY 99
                57999999999999999999999999999999999999999999999999988 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.0026
        KxDL   7 dsedldeilalQaqts...grlnkknreLlelnalsqerlaklrarfkqgtkllkevkkdLesifkkirslkaklak 80 
                 ++e ++e+ ++Q++++   +rlnkk++e  +l + s   l + r+++++  + +  + ++ +  +k i+s+ +++++
  EFC38403.1 206 EKELFSEVFSTQKECLdiiDRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEITSFMRRIQT 282
                 6677999999**997733369*************************************************9998876 PP

>> SpecificRecomb  Site-specific recombinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       1.5   7.7e+02     184     227 ..      50      69 ..      11     108 .. 0.57
   2 ?    8.8   2.1   0.00087      0.44     188     278 ..     192     280 ..     163     287 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.5
  SpecificRecomb 184 qrelealleayeaaledeeeaeedlkhlrvlldqcreavdrvrk 227
                     ++++e                         ll++cr+  +++ +
      EFC38403.1  50 SETIE------------------------ELLEKCRKLYNKINN 69 
                     33333........................333333333333322 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00087
  SpecificRecomb 188 ealleayeaaledeeeaeedlkhlrvlldqcreavdrvrkhleen.GvsvslvfllerlrqrleRleeLldllleeeeeeraralveLlkel 278
                     ++l++++++  +++e ++e  +++ +  ++c +++dr+ k+ ee+     + + ll++ r +l+R++e +d+l  ++ ++++++++++++++
      EFC38403.1 192 ANLTQEQRQ--RHDEIEKELFSEVFSTQKECLDIIDRLNKKSEETiALATDSADLLRQQRDQLRRIDEEMDALG-SNVKRAQKEITSFMRRI 280
                     444444444..666666777788889999**********99988769999999********************7.88899999999988876 PP

>> DUF2203  Uncharacterized conserved protein (DUF2203)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.3      0.13        67      12      71 ..       4      69 ..       2      83 .. 0.65
   2 ?    6.0   0.8     0.037        19      14      68 ..      48     101 ..      41     130 .. 0.60
   3 ?   -0.9   0.1         5   2.6e+03      39      39 ..     183     183 ..     109     213 .. 0.62
   4 ?    9.7   1.2    0.0027       1.4      17      93 ..     208     283 ..     203     291 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.13
     DUF2203 12 Lpllkelleelralrkeleeleeeleeakaeaekse......aaeleaeleeleaeieelveeiee 71
                L +l+  ++el ++++++ee  + l++ + +++++        ++l +++eel ++ ++l ++i++
  EFC38403.1  4 LEKLSTYTHELESVESKIEENITTLRRLNITNQSDPnfissqISTLSETIEELLEKCRKLYNKINN 69
                566777777888888888887777777776654443555555555555555555555555555554 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.037
     DUF2203  14 llkelleelralrkeleeleeeleeakaeaekseaaeleaeleeleaeieelvee 68 
                 +l+e++eel ++ ++l ++ ++l+++  + e+ + +  +++++e+ a++++  ++
  EFC38403.1  48 TLSETIEELLEKCRKLYNKINNLTKNDPSVEN-QVSDTKKKHKEIIAKLRASYKQ 101
                 45555555555555555555555555555433.3555555555555555544433 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 5
     DUF2203  39 a 39 
                  
  EFC38403.1 183 D 183
                 1 PP

  == domain 4  score: 9.7 bits;  conditional E-value: 0.0027
     DUF2203  17 elleelralrkeleeleeeleeakaeaekseaaeleaeleeleaeieelveeieelGvevkdleaglvDFpakldge 93 
                 el++e+ +++ke  ++ ++l+++++e+ +  a+  +  l++ +++++++ ee+++lG +vk +++ +  F  +++ +
  EFC38403.1 208 ELFSEVFSTQKECLDIIDRLNKKSEETIAL-ATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQKEITSFMRRIQTD 283
                 677888888889999999998888886443.7888889999999999999999999999999999999998777655 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0     0.015       7.6      25      56 ..      45      76 ..      40      87 .. 0.81
   2 ?    4.1   1.3      0.14        73      25      53 ..     244     272 ..     232     281 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.015
                HHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXX CS
        SlyX 25 vvaeqqqqidrlqrqlrllaerlkeleessga 56
                ++    ++i++l +++r+l++++++l +++++
  EFC38403.1 45 QISTLSETIEELLEKCRKLYNKINNLTKNDPS 76
                66777889***************999988774 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.14
                 HHHHHHHHHHHHHHHHHHHHHT-XXXXXX CS
        SlyX  25 vvaeqqqqidrlqrqlrllaerlkelees 53 
                  + +q++q+ r+ +++++l  ++k ++++
  EFC38403.1 244 LLRQQRDQLRRIDEEMDALGSNVKRAQKE 272
                 56788888999999999998888777655 PP

>> CENP-H  Centromere protein H (CENP-H)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   6.3     0.019       9.8      19      84 ..      36     104 ..       1     113 [. 0.81
   2 ?    7.7   4.4     0.009       4.6      34      84 ..      51     104 ..      42     143 .. 0.48
   3 ?    6.5   4.5     0.021        11       9      83 ..     207     281 ..     191     291 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.019
      CENP-H  19 sqelrelqeeltevekenlrlkrknrelaaellelakekesek...eklkeelekleaelkksrqrwrv 84 
                 +++ + + ++++++ + + +l +k+r+l +++  l+k++ s +   +++k++ +++ a+l++s +++++
  EFC38403.1  36 QSDPNFISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVEnqvSDTKKKHKEIIAKLRASYKQSKT 104
                 556667788999999999999999999999999999998888888866777777777777777777665 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.009
      CENP-H  34 kenlrlkrknrelaaellelakekesek...eklkeelekleaelkksrqrwrv 84 
                 + + +l +k+r+l +++  l+k++ s +   +++k++ +++ a+l++s +++++
  EFC38403.1  51 ETIEELLEKCRKLYNKINNLTKNDPSVEnqvSDTKKKHKEIIAKLRASYKQSKT 104
                 444444444444444444444444444444433333333333333333333332 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.021
      CENP-H   9 delssellklsqelrelqeeltevekenlrlkrknrelaael.lelakekesekeklkeelekleaelkksrqrwr 83 
                  el se+  +++e+ ++ ++l++  +e+++l + ++ l+++   +l++ +e+ +  l + ++++++e+    +r++
  EFC38403.1 207 KELFSEVFSTQKECLDIIDRLNKKSEETIALATDSADLLRQQrDQLRRIDEEMD-ALGSNVKRAQKEITSFMRRIQ 281
                 5788899999999**********************9999999446666666666.567777777777766666655 PP

>> Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   5.4   0.00022      0.11      78     154 ..      26     102 ..       2     104 .. 0.79
   2 ?    1.2   7.7      0.73   3.7e+02      43     146 ..     175     279 ..     165     283 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 0.00022
  Jnk-SapK_ap_N  78 eeleeiedqweeerkelqekveqleeenrelelkaknaadqlsrleekeaelkkeysklheretellkklkelverq 154
                     +l ++  + +++ + ++++++ l e ++el  k++++ +++++l +++ +++++ s ++++++e++ kl+   ++ 
     EFC38403.1  26 TTLRRLNITNQSDPNFISSQISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTKKKHKEIIAKLRASYKQS 102
                    566677778888888999***************************************************98876665 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.73
  Jnk-SapK_ap_N  43 srneeeeaeleelreeleqLeteyerekelrkrae.eeleeiedqweeerkelqekveqleeenrelelkaknaadqlsrleekeaelkkeysklh 137
                    + +++ +a++ ++ + + +L++e+ +++ + +++   e+  + +++ +    l++k e++          ++++ dql r+ e+ + l ++ ++++
     EFC38403.1 175 EVKRNSDADVTNMYKGNANLTQEQRQRHDEIEKELfSEVFSTQKECLDIIDRLNKKSEETIALATDSADLLRQQRDQLRRIDEEMDALGSNVKRAQ 270
                    555667777777778888887755444433333224333333333333333333333333333333334446888999999999999999999999 PP

  Jnk-SapK_ap_N 138 eretellkk 146
                    ++ t  +++
     EFC38403.1 271 KEITSFMRR 279
                    999988887 PP

>> DUF2935  Domain of unknown function (DUF2935)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   1.7    0.0073       3.7      24      96 ..      48     119 ..       4     132 .. 0.85
   2 ?    2.5   0.5      0.34   1.7e+02      28      91 ..     216     282 ..     154     295 .. 0.68

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0073
     DUF2935  24 lldpkekdlikeakefkkeFekllaeavelseglvrasseleeavakLneealkltreliqFkkellekvlsc 96 
                  l+++ ++l+++ +++ ++ ++l+++  ++++ + + ++++++++ +  + ++k+++ +i+ k++ l++ +s 
  EFC38403.1  48 TLSETIEELLEKCRKLYNKINNLTKNDPSVENQV-SDTKKKHKEIIAKLRASYKQSKTFIETKAKGLNDGKSS 119
                 5677778999999999999999999999999999.66666666665566899**************9998774 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.34
     DUF2935  28 kekdlikeakefkkeFekllaeavelseglv...rasseleeavakLneealkltreliqFkkelle 91 
                 ++k+++++ ++++k+ e++ a a + ++ l     +     e++ +L +++ ++ +e+++F +++++
  EFC38403.1 216 TQKECLDIIDRLNKKSEETIALATDSADLLRqqrDQLRRIDEEMDALGSNVKRAQKEITSFMRRIQT 282
                 3444444444444444444444444444442332222334556667777777777777777777665 PP

>> Plk4_PB2  Polo-like Kinase 4 Polo Box 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.7    0.0038       1.9      45      95 ..      21      73 ..       5      82 .. 0.77
   2 ?   -1.2   0.0       6.2   3.2e+03      62      84 ..      82     104 ..      75     140 .. 0.57
   3 ?    3.0   1.9      0.31   1.6e+02      37      94 ..     178     232 ..     159     288 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0038
    Plk4_PB2 45 iieksg..ksltleseeeleslsselkkllehaeeclkqclklesalssleke 95
                i e+ +  + l+++++++ + +ss+++ l e++ee l++c+kl + +++l+k+
  EFC38403.1 21 IEENITtlRRLNITNQSDPNFISSQISTLSETIEELLEKCRKLYNKINNLTKN 73
                4443333467788888999999*********************9999998876 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 6.2
    Plk4_PB2  62 eslsselkkllehaeeclkqclk 84 
                 +++++++k+++ +++ ++kq   
  EFC38403.1  82 SDTKKKHKEIIAKLRASYKQSKT 104
                 44445555555555555544433 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.31
    Plk4_PB2  37 kssgekvkiieksgksltleseeeleslsselkkllehaeeclkqclklesalsslek 94 
                 ++s+   ++++  + + +l++e + ++ ++  k+l++ + +++k+cl++   l++ ++
  EFC38403.1 178 RNSD--ADVTNMYKGNANLTQE-QRQRHDEIEKELFSEVFSTQKECLDIIDRLNKKSE 232
                 3333..4444444444445444.44455555566777777777788887777766554 PP

>> YlqD  YlqD protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   1.9     0.012       6.4      25      87 ..      42     103 ..      21     108 .. 0.89
   2 ?    0.3   0.6       1.7   8.7e+02      36      79 ..     184     227 ..     170     242 .. 0.45
   3 ?    7.8   0.5    0.0081       4.2      20      52 ..     243     275 ..     235     285 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.012
        YlqD  25 lqaqieqldkelqqLefqakrlikeikkqsaqqieeiqeqvekekserlekkkqllqqleqvq 87 
                 +++qi++l + +++L  + ++l ++i++  +++  ++++qv+  k++ +e +++l++ ++q +
  EFC38403.1  42 ISSQISTLSETIEELLEKCRKLYNKINN-LTKNDPSVENQVSDTKKKHKEIIAKLRASYKQSK 103
                 5789999999999999999999999977.556999********************99999865 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 1.7
        YlqD  36 lqqLefqakrlikeikkqsaqqieeiqeqvekekserlekkkql 79 
                 + ++      l +e+++ + +  +e+ ++v   ++e l+ +++l
  EFC38403.1 184 VTNMYKGNANLTQEQRQRHDEIEKELFSEVFSTQKECLDIIDRL 227
                 33333333333333333333333333333333344444444444 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0081
        YlqD  20 elqqqlqaqieqldkelqqLefqakrlikeikk 52 
                 +l++q ++q++++d+e++ L  + kr+ kei +
  EFC38403.1 243 DLLRQQRDQLRRIDEEMDALGSNVKRAQKEITS 275
                 789999***********************9965 PP

>> Syntaxin_2  Syntaxin-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.3      0.56   2.9e+02      33      65 ..       5      37 ..       3      49 .. 0.78
   2 ?   12.1   7.6   0.00038      0.19       7      82 ..      20     102 ..      19     108 .. 0.80
   3 ?    4.0   4.1      0.12        62      23     100 ..     215     280 ..     185     281 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.56
  Syntaxin_2 33 eklhelieeinelikktnellkklsqldnsssd 65
                ekl + ++e+  + +k++e++  l +l  ++++
  EFC38403.1  5 EKLSTYTHELESVESKIEENITTLRRLNITNQS 37
                688889999999999999999999988776654 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 0.00038
  Syntaxin_2   7 kinsnvstleklvkqLgtkkd.....teelreklhelieeinelikktnellkklsqldnsssds..qqklqkekLkkdfkea 82 
                 ki +n++tl++l  + +++ +        l e ++el e++++l +k+n+l k+  +++n+ sd   ++k + +kL+ ++k++
  EFC38403.1  20 KIEENITTLRRLNITNQSDPNfissqISTLSETIEELLEKCRKLYNKINNLTKNDPSVENQVSDTkkKHKEIIAKLRASYKQS 102
                 78888999998888877774444444888999**********************99999999998666666778888887765 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.12
  Syntaxin_2  23 gtkkdteelreklhelieeinelikktnellkklsqldnsssds..qqklqkekLkkdfkealqeFqkiqrqyaekekqi 100
                 +t+k++ ++ ++l++  ee+  l+++  +                 qq+ q  ++ +++ ++ ++ +++q+++++ +++i
  EFC38403.1 215 STQKECLDIIDRLNKKSEETIALATDSAD--------------LlrQQRDQLRRIDEEMDALGSNVKRAQKEITSFMRRI 280
                 34444444444444444444444444444..............2556666888888888888888888888888777765 PP

>> Spectrin  Spectrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.2     0.011       5.6      40      97 ..       4      61 ..       1      69 [. 0.89
   2 ?    4.1   0.7      0.12        63      29      86 ..      75     132 ..      62     135 .. 0.70
   3 ?    0.8   3.9       1.3   6.8e+02      36      94 ..     195     254 ..     171     262 .. 0.77
   4 ?    4.2   0.7      0.12        62      34      78 ..     243     273 ..     211     283 .. 0.55

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.011
                HHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHTTHTTHHHHHHHHHHHHHHHHHHHHHHH CS
    Spectrin 40 lkkhkaleaelaaqqervkalnelaekl.ldeghsaseeieerleelnerWeeLkelaa 97
                l+k+ ++ +el++ + ++++  ++ ++l +++ +s++  i+++++ l e  eeL+e++ 
  EFC38403.1  4 LEKLSTYTHELESVESKIEENITTLRRLnITN-QSDPNFISSQISTLSETIEELLEKCR 61
                8899999*********************6666.7********************99875 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.12
                 CSSSHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHTTHTTHHHHHHHHHHHH CS
    Spectrin  29 lgkdleevqallkkhkaleaelaa.qqervkalnelaeklldeghsaseeieerleeln 86 
                   +  ++v +  kkhk++ a l+a ++   + +++ a+ l d + s + ++e++ ++l+
  EFC38403.1  75 P-SVENQVSDTKKKHKEIIAKLRAsYKQSKTFIETKAKGLNDGKSSNNSALESTNSNLT 132
                 4.455566777779999999999966666666667788888888888888888877776 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 1.3
                 HHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHTTHTTHHHHHHHHHHHHHHHHHHHH CS
    Spectrin  36 vqallkkhkaleaelaa.qqervkalnelaeklldeghsaseeieerleelnerWeeLke 94 
                 +q++ ++h+++e+el +      k++ ++ ++l ++++++ +  +++ + l+++ ++L++
  EFC38403.1 195 TQEQRQRHDEIEKELFSeVFSTQKECLDIIDRLNKKSEETIALATDSADLLRQQRDQLRR 254
                 688888999999999775667777777888888777778888888888888888888876 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.12
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHTTHHHH CS
    Spectrin  34 eevqallkkhkaleaelaaqqervkalnelaeklldeghsaseei 78 
                 + ++++ ++++++ +e++a   +vk+ +              +ei
  EFC38403.1 243 DLLRQQRDQLRRIDEEMDALGSNVKRAQ--------------KEI 273
                 4444444466666666666666666555..............444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3302  (0.184171); expected 358.6 (0.02)
Passed bias filter:                      946  (0.0527637); expected 358.6 (0.02)
Passed Vit filter:                       137  (0.00764125); expected 17.9 (0.001)
Passed Fwd filter:                        67  (0.00373696); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              35  [number of targets reported over threshold]
# CPU time: 1.20u 0.40s 00:00:01.60 Elapsed: 00:00:00.57
# Mc/sec: 1786.14
//
Query:       EFC38404.1  [L=1671]
Description: hypothetical protein NAEGRDRAFT_73885 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.7e-28   97.5   1.7      8e-28   97.0   0.1    2.1  2  G8            G8 domain
    1.5e-07   31.1   0.2      3e-07   30.1   0.2    1.5  1  RGM_C         Repulsive guidance molecule (RGM) C-terminus
    0.00014   22.2   0.4    0.00062   20.1   0.4    2.1  1  fn3           Fibronectin type III domain
    0.00072   19.9  66.4    0.00079   19.7   9.1    4.7  5  EGF_2         EGF-like domain
      0.005   16.9   9.6      0.005   16.9   9.6    4.5  4  EGF_Tenascin  Tenascin EGF domain
  ------ inclusion threshold ------
        4.5    7.2   8.2        8.2    6.4   0.0    3.2  3  DUF4950       Domain of unknown function (DUF4950)
        6.3    7.0  10.7         17    5.5  10.7    1.7  1  Insulin_TMD   Insulin receptor trans-membrane segment


Domain annotation for each model (and alignments):
>> G8  G8 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.0   0.1   3.1e-31     8e-28      10     122 ..     327     440 ..     319     441 .. 0.93
   2 ?   -4.1   0.1       6.2   1.6e+04      12      45 ..    1272    1305 ..    1266    1312 .. 0.57

  Alignments for each domain:
  == domain 1  score: 97.0 bits;  conditional E-value: 3.1e-31
          G8  10 egdnvvIpagktvlldvsspklrsllveGtLifsddk.....sdielnaeyilvqggGkleiGteeepfkgkatItLyGteewsstelpdlgaKvlavs 103
                 +++ v+Ip++kt++ldvs+pkl++++v+G Lif++++      d++l+++ ++v+  G+l+iG+e+ p+++katItLyG  e ++ +   +g+K +av+
  EFC38404.1 327 SASFVTIPSDKTIILDVSPPKLDTVMVYGCLIFDNNDygnetLDLQLQMNSMVVT--GSLQIGNESTPYQHKATITLYG--EKTPLSDKGVGNKNIAVM 421
                 6788*****************************66669*999999**********..9*********************..777778899********* PP

          G8 104 ngGtlelhGqprkktwtkL 122
                 +gG l+lhG+++++twt L
  EFC38404.1 422 SGGVLSLHGKRHEVTWTLL 440
                 *****************98 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 6.2
          G8   12 dnvvIpagktvlldvsspklrsllveGtLifsdd 45  
                  d vv  +g+ v l ++  +++ +  + tL++++d
  EFC38404.1 1272 DVVVYVNGQVVDLKETVVNVQAVENNATLEIPKD 1305
                  4444445555555544444444444488888666 PP

>> RGM_C  Repulsive guidance molecule (RGM) C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.2   1.2e-10     3e-07     115     165 ..    1481    1530 ..    1463    1538 .. 0.85

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 1.2e-10
       RGM_C  115 aeskkaltleeaeekCreklevedvYfdsCvFDllttGdanftlaaksale 165 
                  a+s++++  e a++ C +   ++ +++++C+FD+++tGd++f +a+ +a++
  EFC38404.1 1481 ATSENQTLNELAKKICTNL-GLTGTFYQTCLFDVISTGDTSFAMASANAVA 1530
                  45667778899*****999.*************************998864 PP

>> fn3  Fibronectin type III domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.4   2.4e-07   0.00062      13      77 ..      87     151 ..      77     155 .. 0.86

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 2.4e-07
                 SSEEEEEEE-CSSSSSTEEEEEEEEEETTSTS.TEEEEEECSTSSEEEEESSSTTEEEEEEEEEEE CS
         fn3  13 stsltvsWeppkdgggpitgYeveyrekgsee.ewneftvprtttsvtltgLkpgteYevrVqavn 77 
                   s+ ++W+ ++d    i +Y+++ ++ +s + +++ +     + ++t  +L  + +Y++rV  +n
  EFC38404.1  87 YFSIELRWKLSNDTTNVICYYQIQMSTLNSLGyVTVMYKTHQAE-TYTRFNLDQNVTYSFRVLPYN 151
                 55899***************************766666777777.*****************8666 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.2       5.9   1.5e+04      23      32 .]     313     322 ..     312     322 .. 0.83
   2 ?   -7.2   5.4         7   1.8e+04       8      22 ..     824     835 ..     821     838 .. 0.74
   3 !   13.5  11.7   2.8e-05     0.071       1      32 []    1147    1178 ..    1147    1178 .. 0.90
   4 !   19.7   9.1   3.1e-07   0.00079       1      32 []    1183    1212 ..    1183    1212 .. 0.88
   5 !   15.5  10.7   6.5e-06     0.017       1      32 []    1546    1572 ..    1541    1572 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 5.9
       EGF_2  23 CdsgyqGktC 32 
                 C+++y   tC
  EFC38404.1 313 CKTSYKNTTC 322
                 8999988888 PP

  == domain 2  score: -7.2 bits;  conditional E-value: 7
       EGF_2   8 CgghGtCvnqcGqCd 22 
                  g+ G+C    G C+
  EFC38404.1 824 KGNTGSCA--YG-CY 835
                 578999*9..77.64 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 2.8e-05
       EGF_2    1 CsasdeiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  C +  ++Cgg  +G+Cv ++  C+C  g+ G++C
  EFC38404.1 1147 CANY-SNCGGakRGKCVGLN-DCVCRWGWMGDDC 1178
                  7775.77**********777.9************ PP

  == domain 4  score: 19.7 bits;  conditional E-value: 3.1e-07
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C + ++ C+ hGtCv ++  C+C++g+ G++C
  EFC38404.1 1183 CAH-KDWCSEHGTCVGPN-ICSCFPGFAGAKC 1212
                  555.567********888.9************ PP

  == domain 5  score: 15.5 bits;  conditional E-value: 6.5e-06
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C+++   C+ +G+C    G+C+C sg+ G +C
  EFC38404.1 1546 CPNH---CSLNGICL--DGVCQCLSGFLGSDC 1572
                  8877...*******9..9************** PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.7         5   1.3e+04      18      29 .]     255     266 ..     254     266 .. 0.90
   2 !    5.6   6.9    0.0067        17       4      29 .]    1153    1179 ..    1150    1179 .. 0.86
   3 ?    0.2   1.6      0.33   8.5e+02       6      28 ..    1189    1212 ..    1188    1213 .. 0.70
   4 !   16.9   9.6   1.9e-06     0.005       2      29 .]    1546    1573 ..    1545    1573 .. 0.98

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 5
  EGF_Tenascin  18 iCDsEYsGDDCs 29 
                   iC+   sG +Cs
    EFC38404.1 255 ICNFTDSGTNCS 266
                   899999*****8 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0067
  EGF_Tenascin    4 LGCssRGvCvD.GqCiCDsEYsGDDCs 29  
                     G + RG Cv    C+C   + GDDCs
    EFC38404.1 1153 CGGAKRGKCVGlNDCVCRWGWMGDDCS 1179
                    57789*****7468************9 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.33
  EGF_Tenascin    6 CssRGvCvDGq.CiCDsEYsGDDC 28  
                    Cs  G Cv    C C   ++G  C
    EFC38404.1 1189 CSEHGTCVGPNiCSCFPGFAGAKC 1212
                    ********6433666666666666 PP

  == domain 4  score: 16.9 bits;  conditional E-value: 1.9e-06
  EGF_Tenascin    2 CPLGCssRGvCvDGqCiCDsEYsGDDCs 29  
                    CP  Cs  G+C DG C C s + G DCs
    EFC38404.1 1546 CPNHCSLNGICLDGVCQCLSGFLGSDCS 1573
                    ***************************9 PP

>> DUF4950  Domain of unknown function (DUF4950)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   1.2       2.7     7e+03      22      52 ..     200     230 ..     197     233 .. 0.76
   2 ?    4.2   0.5     0.015        38     102     170 ..    1254    1330 ..    1240    1338 .. 0.78
   3 ?    6.4   0.0    0.0032       8.2      58      82 ..    1448    1472 ..    1440    1499 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.7
     DUF4950  22 eetkknesnvisktsqvvssssvkktlmevs 52 
                 + t +n+s v+ +t +  s+  + +     s
  EFC38404.1 200 NSTYSNYSTVSNETVKCPSTQQIVECESSYS 230
                 5688999999999999888877777666555 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.015
     DUF4950  102 mssllnntprtlikesdGt....ltvdGelytylgnitleqllersnk......kqkvykqsetqaPensdsieditns 170 
                  +s++ +    t+   sdGt    + v+G++      ++  q +e +         q+ y+q   q   +++ i +i+ +
  EFC38404.1 1254 ISFQSG--TDTVEVSSDGTndvvVYVNGQVVDLKETVVNVQAVENNATleipkdLQNFYDQIKYQRDPDTNEIPQIQQT 1330
                  555555..668888888884433568****8888888889999998889999888999999988877789999999975 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0032
     DUF4950   58 GGwGiPqsdnlffinedGtlssitv 82  
                    w +Pqs+  f   +d t+ si+ 
  EFC38404.1 1448 ESWRVPQSESYFIYTADETYNSINI 1472
                  57*******************9974 PP

>> Insulin_TMD  Insulin receptor trans-membrane segment
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5  10.7    0.0067        17      13      39 ..    1580    1607 ..    1574    1608 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0067
  Insulin_TMD   13 nivkIvigPviciillllvi.gavfvvv 39  
                   + + I+ig vi ++++l++i +a+fv++
   EFC38404.1 1580 QFASIIIGAVISVVVVLVIIlVAIFVLF 1607
                   7899********9998877638999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1671 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1253  (0.0698868); expected 358.6 (0.02)
Passed bias filter:                      670  (0.0373696); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.18u 0.37s 00:00:01.54 Elapsed: 00:00:00.56
# Mc/sec: 8933.94
//
Query:       EFC38405.1  [L=1272]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-29  102.9   0.0    4.1e-29  101.5   0.0    1.7  1  Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransf


Domain annotation for each model (and alignments):
>> Glyco_transf_10  Glycosyltransferase family 10 (fucosyltransferase) C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.5   0.0   2.3e-33   4.1e-29       5     143 ..     360     498 ..     357     523 .. 0.86

  Alignments for each domain:
  == domain 1  score: 101.5 bits;  conditional E-value: 2.3e-33
  Glyco_transf_10   5 vawvvsncktkskRekyvkeLkkhlevdvyGkcgklkveelsekeveelikkykFYLafEnsickDYiTeKlwnale.....agavPvvlGpar 93 
                      ++ ++snc ++  R+++vke+++ l+v  yG cg++   +++  +v el++++kFYLafEns+ +DYiTeK+++ ++      + v +  G++ 
       EFC38405.1 360 ICAFISNCVKE--RMDVVKEISNVLPVRQYGGCGRNA--HEQGGKVAELARSCKFYLAFENSMLDDYITEKFFEGFTplglgGKLVSIYRGAP- 448
                      78999***876..********************9888..89999****************************965332223378999999999. PP

  Glyco_transf_10  94 enyerfvppdsfihvddFkspkelaeyLkkldkneeeYleYfeWrkkykv 143
                      +  e   p+dsfi+++dFksp+e+a+++k   +++++++eYf+ r + ++
       EFC38405.1 449 NINEYGFPKDSFISIHDFKSPTEMAQHIKPYCDDDQKFNEYFKQRMSDET 498
                      4445669***********************************98877655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1609  (0.0897429); expected 358.6 (0.02)
Passed bias filter:                      739  (0.0412181); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.04u 0.31s 00:00:01.35 Elapsed: 00:00:00.52
# Mc/sec: 7306.47
//
Query:       EFC38406.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    8.7e-11   41.7   0.2    1.6e-10   40.8   0.1    1.4  2  SBP_bac_3  Bacterial extracellular solute-binding proteins, f
  ------ inclusion threshold ------
       0.11   13.0   0.7        2.1    8.9   0.1    2.4  2  WAK        Wall-associated kinase


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0      0.68   6.1e+03     198     214 ..      39      55 ..      34      57 .. 0.78
   2 !   40.8   0.1   1.8e-14   1.6e-10      40     181 ..     130     273 ..     114     287 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 0.68
                 HHHHHHHHHHHHHHTTH CS
                 xxxxxxxxxxxxxxxxx RF
   SBP_bac_3 198 Lrkainkalaelkadgt 214
                   +ai++a +e+++d t
  EFC38406.1  39 YSDAIDAATQEMITDTT 55 
                 56789999999998876 PP

  == domain 2  score: 40.8 bits;  conditional E-value: 1.8e-14
                 EEEEE...-.SGGGHHHHHHTTSSSEEESSEB--HHHHTTEEEESESEEEEEEEEEEE.TTSHGTCCHSSCGCGTTS..EEEEETTSHHHHHHHHHHHC CS
                 xxxxx...x.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3  40 vefvp...v.swdelipalksgkvDiaiaaititpeReekvdFsqpyfsagqvllvrk.kdaskissiksladLkgk..kvgvqagstaeellkeelkk 131
                 v++v+      +d++ +a++sg +D++  ++  +++R++ v F  p+ +++ ++l  + + + + s++k   +L++    v++ ag+t+e  +k +l+ 
  EFC38406.1 130 VKYVNttaLgFFDTMKNAVNSGICDVISVNVEQNDARRKAVHFQCPWGTTSKAFLRTElDPQLELSTYK---SLNQSnvIVATYAGTTYEIDVKTNLP- 224
                 555555554589********************************************9977665555555...775542279999******99**9887. PP

                 TSEEEEESSHHHHHHHHHTTSSSEEEEEHHHHHHHHHHCCGCCEEEEECG CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 132 gaeivefdtleealqaLkngrvdavvadspvlaylvkknpdkkvvlveep 181
                  a+ ++f t e   +++ +++v avv++ ++   +++ n ++ +   +++
  EFC38406.1 225 AAQYISFGTPETQWKLILDKKVHAVVYNAVTFLSWLDSNRANCKNC-SVV 273
                 99**********************************9999887766.444 PP

>> WAK  Wall-associated kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.031   2.8e+02      16      39 ..     150     174 ..     142     214 .. 0.66
   2 ?    8.9   0.1   0.00023       2.1      30      75 ..     261     310 ..     244     312 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.031
         WAK  16 aerqqvigveiesseentttk.egC 39 
                 ++   vi+v++e+++++++    +C
  EFC38406.1 150 SGICDVISVNVEQNDARRKAVhFQC 174
                 566789******9998655432444 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00023
         WAK  30 eentttkegCkvaFltd....ekyslsnvtepeklhakgyatveLgWvld 75 
                 ++n+ + ++C v F+ +    ++++++n+t  +   ++g ++v++ W+++
  EFC38406.1 261 DSNRANCKNCSVVFINQpyafSTFTTMNITARNDASTTGMSVVNIYWIFA 310
                 566666789******9844334677899*******************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       872  (0.0486363); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.55
# Mc/sec: 1736.52
//
Query:       EFC38407.1  [L=1090]
Description: hypothetical protein NAEGRDRAFT_81644 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-45  155.4  39.3      2e-45  155.4  39.3    2.6  3  Choline_transpo  Plasma-membrane choline transporter
     0.0066   16.8   1.7      0.021   15.2   1.7    1.8  1  EPL1             Enhancer of polycomb-like
  ------ inclusion threshold ------
      0.017   15.5   0.1       0.14   12.6   0.1    2.6  1  Ycf70            Uncharacterized Ycf70-like
       0.58   10.8   5.4         23    5.6   0.0    2.6  2  Pex14_N          Peroxisomal membrane anchor protein (Pex14p)


Domain annotation for each model (and alignments):
>> Choline_transpo  Plasma-membrane choline transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1      0.68     3e+03      50      62 ..     129     141 ..     124     178 .. 0.54
   2 ?   -0.9   7.6      0.16   7.3e+02      11      71 ..     524     581 ..     518     615 .. 0.62
   3 !  155.4  39.3   4.4e-49     2e-45       4     326 .]     622    1047 ..     619    1047 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.68
  Choline_transpo  50 lllllvsafwivv 62 
                      ++++l+++ +i++
       EFC38407.1 129 IVFILFCIGMIAI 141
                      2222222222222 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.16
  Choline_transpo  11 llllivlrkrirlaiallkvaskaiksnpslllvplltllllllvsafwivvavalylass 71 
                      + +l+  +k i +++ +  ++s +   ++ +l+ pl+   ++ll++a+++++++ l+    
       EFC38407.1 524 VTMLYNSWKIILISVTITAAVSFITVVLLRVLAKPLIYGTVALLILAWFSLSIMLLV---E 581
                      556666777666666666555555555668888888888888888888888774443...2 PP

  == domain 3  score: 155.4 bits;  conditional E-value: 4.4e-49
  Choline_transpo    4 livavllllllivlrk.rirlaiallkvaskaiksnpslll.vplltllllllvsafwivvavalylassgestdkv............... 78  
                       l+  +l+ ++++ ++k  +  +++++k+++ +i+ +p++++ +p+++++  ++++++w++v++ l+ +   +    +               
       EFC38407.1  622 LFTNLLFTFIFWNYWKkTLSRSVSIIKESAMIITTVPQMFTvLPIAIFIGGIIFCVWWFCVVALLL-TNELTA---Agitdasslagkvtsn 709 
                       4455566666666665278******************7765279999999********99995553.222222...1234566899999999 PP

  Choline_transpo   79 ...............nsgsesglaavefessskvkalllyllfgllWtleflralqqvtvagavasWYfs..kkkdlp.....skfpvl... 145 
                                      n +s+          s  +k+ ++y+l+g++W+++fl  +++++va + +++Yf+  +   ++          +   
       EFC38407.1  710 iatgntltekmqslsNPTSF-----ILTLQSHLLKGWFAYYLLGFFWITQFLLSFVTIVVARVTSTFYFKfgN---VSgtitaA----Rrge 789 
                       ********987543322222.....222345678999*********************************541...22122230....1334 PP

  Choline_transpo  146 .....................kslkraltyhlGSialgSlilaivqllrliley........lekklkkk...................... 186 
                                            ++   ++ y+ GSial+Sl++++v+ l l+++                +                      
       EFC38407.1  790 sssaifdsyektlmclklpvlQASLFVMYYNAGSIALASLFVGLVKYLILVIKTslslmgyqS------Ekstveqavesqffivrfinnfr 875 
                       444444555555555556666********************************8555433321......03345567888899999999998 PP

  Choline_transpo  187 enavakcllcclkcclwclekflkflnrnayimvaiyGksFcesakdafellkrnglrvavldsvvdfvlflgkllialltgliaylllkat 278 
                       +n +++++  +l ++l ++ekf++f+ rn++i++ai G+ F++s+ ++++l+++n++ +avl++++d+++f  k+l+a++++ +ay++++a+
       EFC38407.1  876 NNFLTRFIHRILFVILKYIEKFMEFFARNSLIHCAIFGTTFFHSSLSSTKLMRKNITFIAVLEWITDWIMFCMKMLVAIISVAVAYIIIHAQ 967 
                       888899********************************************************************************999988 PP

  Choline_transpo  279 ltnpe................................elnsplvpllvvfiiayliasiflsvyesavdtifvcfaeDpe 326 
                       +++ e                                ++n+ +++l++vf ++ l++s+f++++++++dt+++c+++D e
       EFC38407.1  968 DKSLEeftsvvgkitnayneqgnyglfeivfsgkewlDVNHSFMLLVIVFAMSVLVSSLFITIFQTVIDTVLQCYLIDLE 1047
                       8888899999999999999999********************************************************86 PP

>> EPL1  Enhancer of polycomb-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   1.7   4.6e-06     0.021      40      89 ..      33      86 ..       4     174 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 4.6e-06
        EPL1 40 nsqqavetgvdkkeenekh.q.viaaakkkesssasskeslkkeelkLpkP..s 89
                +++++++++++ +++n+++ +  +++a+++++ s++++++  + ++++pkP   
  EFC38407.1 33 TKINQTNQQQQTSTNNNHTtNkTTNSANNNNNTSSHNNNNGGRPSATIPKPslD 86
                223334444444444555556677777777777777777889999******552 PP

>> Ycf70  Uncharacterized Ycf70-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   3.2e-05      0.14      26      57 ..     608     639 ..     589     650 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.2e-05
       Ycf70  26 yweellvmvsglyalfcvflvlfiffdsfkqe 57 
                  we+ l + sgl+ lf  +l  fif++ +k+ 
  EFC38407.1 608 TWENSLYLGSGLFLLFTNLLFTFIFWNYWKKT 639
                 5*************************999875 PP

>> Pex14_N  Peroxisomal membrane anchor protein (Pex14p) conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   3.3     0.011        49      57     101 ..      35      71 ..      16     118 .. 0.49
   2 ?    5.6   0.0     0.005        23     125     157 .]     528     560 ..     435     560 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.011
     Pex14_N  57 vaassaseqaqeesasssatpqpqaasqtsqsspspsppaqqqqq 101
                 ++++++++q+        +t+++ ++++t++s+++++++++++++
  EFC38407.1  35 INQTNQQQQT--------STNNNHTTNKTTNSANNNNNTSSHNNN 71 
                 1221111111........111111111111111222211222222 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.005
     Pex14_N 125 lrtwrdllitatalaglgaglyglskryiaPmi 157
                 + +w+ +li +t++a+++++++ l + + +P+i
  EFC38407.1 528 YNSWKIILISVTITAAVSFITVVLLRVLAKPLI 560
                 349*************************99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1090 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2082  (0.116125); expected 358.6 (0.02)
Passed bias filter:                      616  (0.0343577); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.96u 0.36s 00:00:01.31 Elapsed: 00:00:00.54
# Mc/sec: 6080.11
//
Query:       EFC38408.1  [L=1060]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-08   34.8   0.0    2.5e-08   34.8   0.0    2.8  2  CAP       Cysteine-rich secretory protein family
    6.5e-08   32.8  73.2    0.00036   20.8  13.8    4.5  4  EGF_2     EGF-like domain
  ------ inclusion threshold ------
        0.6   10.8  53.4       0.26   12.0   9.1    5.2  4  hEGF      Human growth factor-like EGF
        2.7    7.8   5.4        0.7    9.7   0.9    2.5  3  DUF2922   Protein of unknown function (DUF2922)


Domain annotation for each model (and alignments):
>> CAP  Cysteine-rich secretory protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.8   0.0   5.6e-12   2.5e-08       9     126 .]     135     246 ..     108     246 .. 0.83
   2 ?   -3.9   4.9         4   1.8e+04     101     124 ..     482     502 ..     450     506 .. 0.80

  Alignments for each domain:
  == domain 1  score: 34.8 bits;  conditional E-value: 5.6e-12
                 HHTT----EE-HHHHHHHHHHHHHHHHH.T---S-GGG--HHHHHHTT-T......EEEEEES--CCCHHHHHHTSHH.............HHHHHT-S CS
         CAP   9 aaaglppLkwdatLekaAqdhardcaashsdsssspeggdllkyaenagk......eniaaaseaaedavdsWysepgtynkgketegsighftnllwp 101
                   +glppL    +L  + + h++d+a+  +++++s++g+ ++++++ ++       eniaa++ ++ ++  +W+++ g             h++n+l +
  EFC38408.1 135 ETTGLPPLFEHFNLVESGRFHSKDMATVPCFQHNSCDGTLTFTRVATFYTkpaamaENIAAGQTSPLSVTMAWINSDG-------------HRANILGS 220
                 66788888888888888999*****8888*************************999*********************.............******** PP

                 S--EEEEEEEEBTTS-E...EEEEEE CS
         CAP 102 kstkvGcavatcgngsf.tfivvcny 126
                 ++t +G++++   + +    ++++n+
  EFC38408.1 221 SYTLLGVGHYPKVAATGfSDYWTQNF 246
                 *********87766655677899987 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 4
                 SS--EEEEEEEEBTTS-E..EEEE CS
         CAP 101 pkstkvGcavatcgngsftfivvc 124
                 ++s+k Gc++ +c+  +   i++c
  EFC38408.1 482 DCSSKGGCGFGQCTGPN---ICTC 502
                 8999*********8663...5777 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9  11.7   5.5e-06     0.025       1      32 []     381     410 ..     381     410 .. 0.85
   2 !   16.5  11.8   1.8e-06     0.008       6      32 .]     419     444 ..     415     444 .. 0.90
   3 !   20.8  13.8   8.1e-08   0.00036       6      32 .]     453     478 ..     449     478 .. 0.90
   4 ?   -0.9  11.9      0.52   2.3e+03       1      27 [.     483     506 ..     482     511 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 5.5e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C    ++C+g+G C +  + C C++gy G tC
  EFC38408.1 381 CAGV-NNCNGNGDCLA-INTCLCKAGYKGSTC 410
                 5554.78*******84.569************ PP

  == domain 2  score: 16.5 bits;  conditional E-value: 1.8e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C ++G+C  ++ +C C+sgy+G++C
  EFC38408.1 419 SNCMNRGQCTGPN-VCTCQSGYTGASC 444
                 57********888.************* PP

  == domain 3  score: 20.8 bits;  conditional E-value: 8.1e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+g+GtC +++ +C C+sgy+G +C
  EFC38408.1 453 NNCNGNGTCTSPN-VCTCKSGYTGSDC 478
                 68********999.************* PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.52
       EGF_2   1 Csas.deiCgghGtCvnqcGqCdCdsgy 27 
                 Cs+  +  Cg  G+C  ++  C C+++y
  EFC38408.1 483 CSSKgG--CG-FGQCTGPN-ICTCPANY 506
                 665434..75.89999777.9****998 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   4.5   0.00039       1.7       1      22 []     387     405 ..     387     405 .. 0.88
   2 ?    8.7   8.4   0.00065       2.9       1      22 []     421     439 ..     421     439 .. 0.95
   3 ?   12.0   9.1   5.8e-05      0.26       1      22 []     455     473 ..     455     473 .. 0.93
   4 ?   -2.0   7.5       1.4   6.4e+03       3      19 ..     491     503 ..     489     504 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00039
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G C   ++  +C C+ Gy
  EFC38408.1 387 CNGNGDCL-AIN--TCLCKAGY 405
                 ********.444..6******9 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00065
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C n G+C+   g ++C C +Gy
  EFC38408.1 421 CMNRGQCT---GPNVCTCQSGY 439
                 ********...779*******9 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 5.8e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++GtC+     ++C C++Gy
  EFC38408.1 455 CNGNGTCT---SPNVCTCKSGY 473
                 ********...558*******9 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.4
                 TT-EES..-SS.-EE-- CS
        hEGF   3 ngGtCidgvggykCiCp 19 
                   G+C+   g + C Cp
  EFC38408.1 491 F-GQCT---GPNICTCP 503
                 4.5***...779****9 PP

>> DUF2922  Protein of unknown function (DUF2922)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.9   0.00016       0.7       7      64 ..     711     766 ..     710     769 .. 0.74
   2 ?   -3.2   0.0       1.6   7.3e+03      22      37 ..     854     869 ..     852     871 .. 0.82
   3 ?   -2.9   0.0       1.3   5.8e+03      21      45 ..     935     959 ..     924     965 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00016
     DUF2922   7 FkteegktvtlsipnpkedlteaeVkaaMdlIiakniFttkggdlvekksAkivettt 64 
                 F+t e kt  l+i++p     ++eV ++ + +i++  ++ +     ++   k+++t++
  EFC38408.1 711 FTTVE-KTKVLTIQDPTTTMSAQEVSSLVNSLISSTSLS-SLEIANSLLNSKLTTTEK 766
                 55555.8999***********************987775.333455555555555555 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.6
     DUF2922  22 pkedlteaeVkaaMdl 37 
                  k  +++ +V aaM l
  EFC38408.1 854 LKKVIDASQVGAAMSL 869
                 57789999******86 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 1.3
     DUF2922  21 npkedlteaeVkaaMdlIiakniFt 45 
                  + +++ +    ++   Ii+ ni++
  EFC38408.1 935 IISQNIYSHIKTDLVSSIISINILS 959
                 4444444443344555666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1060 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1265  (0.0705561); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.83u 0.31s 00:00:01.13 Elapsed: 00:00:00.54
# Mc/sec: 5891.33
//
Query:       EFC38409.1  [L=516]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-73  248.6   1.1    1.4e-73  248.2   1.1    1.0  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  248.2   1.1   7.9e-78   1.4e-73       8     449 ..      58     489 ..      52     503 .. 0.85

  Alignments for each domain:
  == domain 1  score: 248.2 bits;  conditional E-value: 7.9e-78
                 HCCHCHHHHTTTCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHH CS
        p450   8 plvgnllqlgrkeelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltptl 106
                 pl+     +g+ +e+ +v++++++   ++ r+     p+v++s+p+++ke +i k+ + + +   + ++ +  +f ++ v   n e+wk++ +++ p++
  EFC38409.1  58 PLLSPYYYFGSVKEIENVVDSYSNDETKTARIVTKDAPIVLISDPKLFKEFFILKA-NCYEK---PDFK-FITMFGENIVSAVNNERWKRHFKVCSPAF 151
                 55555555555566778889999999999**************************5.55555...4444.233788888888888************** PP

                 TSHSTT.THHHHHHHHHHHHHHHHHCCCCHCSEEETHHHHHHHHHHHHHHHHHSSHHHTTTSSH.HHHHHHHHHHHHHHHHCHHHHCCCCCHHHTCCSC CS
        p450 107 tsfgkl.sleelveeeaedlveklrkkagesselditellskaaldvigsilFgarfdlledek.lselvkaveelssllskssvqllllfpllkylpt 203
                   + +l  + ++ +++ae l e++ k+ +    +   +++s+++ldv+g+  F+  f++  +++  + +++  ++ +s+ +    +l+   + l+ +++
  EFC38409.1 152 SPQ-NLiYVCQVACQSAELLFERWSKDESGV--MLSNDDFSDITLDVLGKAGFNLDFGIFSSNQeGKAFKTSLQQTFSMKALAIRRLFGNGK-LQTIMS 246
                 *99.9999*****************999888..999**********************5554442345566666666655444445555555.888999 PP

                 HHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC..SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHH CS
        p450 204 kllrklkeavkklkdlldklieerretldsa..kksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklr 300
                 k+   + +  ++ ++ ld++i+ r++ l+++   ++ +d l +l++a     + + ++d+el+ +   + faG+dTts+ l+w+ +e+ knP++q++l+
  EFC38409.1 247 KIVGIHGHL-ETCSKSLDEMIQSRKKLLEDKplINDMNDILTLLVKAN--MTE-KLITDDELKSNSVIMSFAGHDTTSTLLQWTTFEISKNPTIQQELY 341
                 999999966.*********************87556777777777774..333.379****************************************** PP

                 HHHHHHCCTTTT-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTS.CTESS CS
        p450 301 eEidevlgdkreptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRFldekg.nskrk 398
                 +Ei +++g++  pt+dd+ +l++++ v+ E++Rlhp+v   l+R++ k++++++++ipkGt+v +  ++l+++p+v+++P eF  +RF d +  +s+ +
  EFC38409.1 342 NEISKTIGRR-DPTIDDFPNLHLVNSVLMESFRLHPAVQ-ILSRVAVKNTTLGNFSIPKGTHVATLFGYLMKRPDVWEKPTEFIADRFVDPQFrESSFH 438
                 *********5.6***************************.999************************************************9887779* PP

                 CTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESS CS
        p450 399 sfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppilek 449
                 +f f+PF++G R+C+G+++  +e  ++l++++q+Fe+el ++ ++ pi   
  EFC38409.1 439 NFTFVPFSMGNRACLGKKFSLLESCMILTKMIQRFEFELLNDLEKDPIVAI 489
                 ***************************************988877777654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (516 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       743  (0.0414412); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 3032.56
//
Query:       EFC38410.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-22   76.2  23.3      4e-06   26.5   0.1    7.2  7  LRR_6     Leucine Rich repeat
    1.7e-19   69.3  23.3    8.7e-07   28.6   8.9    3.8  4  LRR_8     Leucine rich repeat
    9.5e-14   51.3  31.2    5.7e-06   26.6   3.0    5.0  5  LRR_4     Leucine Rich repeats (2 copies)
    5.7e-05   23.1  15.7        1.7    9.5   0.2    6.6  6  LRR_1     Leucine Rich Repeat
    0.00098   18.7   5.6       0.19   11.2   1.8    2.4  2  LRR_9     Leucine-rich repeat
     0.0047   17.1   4.1       0.18   11.9   1.0    2.3  2  NKWYS     Putative capsular polysaccharide synthesis protein
  ------ inclusion threshold ------
      0.079   13.3   0.6       0.31   11.3   0.0    2.1  2  DUF5471   Family of unknown function (DUF5471)
       0.28   11.5   3.4        2.8    8.3   0.1    3.5  3  DUF424    Protein of unknown function (DUF424)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.0   0.1   7.5e-05      0.17       4      24 .]      24      44 ..      21      44 .. 0.91
   2 !    6.0   0.2    0.0065        15       3      15 ..      47      59 ..      45      59 .. 0.87
   3 !   10.4   1.0   0.00025      0.56       3      17 ..      70      84 ..      68      84 .. 0.91
   4 !   26.5   0.1   1.8e-09     4e-06       3      24 .]      95     116 ..      93     116 .. 0.93
   5 !   20.2   0.1   1.7e-07   0.00039       3      23 ..     119     139 ..     117     140 .. 0.89
   6 !   11.3   0.0   0.00013      0.28       3      24 .]     143     164 ..     141     164 .. 0.91
   7 ?    2.1   0.0      0.11   2.5e+02       4      23 ..     168     188 ..     165     189 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 7.5e-05
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                ++t+L L++N+Ig +Ga++++
  EFC38410.1 24 NVTKLTLNHNNIGIQGAKSIS 44
                799***************996 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0065
       LRR_6  3 thLteLdLsgNdI 15
                 hLt+L++s N+I
  EFC38410.1 47 EHLTSLNISINGI 59
                59*******9887 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00025
       LRR_6  3 thLteLdLsgNdIgD 17
                 +LteLd+s N +gD
  EFC38410.1 70 KNLTELDISNNLLGD 84
                58***********99 PP

  == domain 4  score: 26.5 bits;  conditional E-value: 1.8e-09
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt L++s+N I+DeGa++L+
  EFC38410.1  95 QKLTILNISCNRINDEGAKSLS 116
                 89******************96 PP

  == domain 5  score: 20.2 bits;  conditional E-value: 1.7e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 + Lt L+++ N+IgDeGa+ +
  EFC38410.1 119 NQLTNLNIRLNEIGDEGAKFI 139
                 579***************976 PP

  == domain 6  score: 11.3 bits;  conditional E-value: 0.00013
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt L + +N+I+ +Ga+ L+
  EFC38410.1 143 QNLTLLTIDHNQIQTQGAKYLS 164
                 799***************9885 PP

  == domain 7  score: 2.1 bits;  conditional E-value: 0.11
       LRR_6   4 hLteLdLsgNd.IgDeGaeaL 23 
                 +L++L + gN+ I  eG +a+
  EFC38410.1 168 NLKTLYIHGNEnIEREGSKAI 188
                 89*********9999998887 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.8   4.5e-08    0.0001      20      61 .]      18      59 ..      16      59 .. 0.92
   2 !   12.1   0.3   5.6e-05      0.13      20      41 ..      65      86 ..      62      90 .. 0.81
   3 !   28.6   8.9   3.9e-10   8.7e-07       2      61 .]      71     131 ..      70     131 .. 0.91
   4 !   27.0   0.5   1.2e-09   2.8e-06       2      58 ..     144     201 ..     139     204 .. 0.95

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 4.5e-08
                SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8 20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                + ++++n++ L L++N++    ++++s+L++L+sL++s N +
  EFC38410.1 18 SLRKMKNVTKLTLNHNNIGIQGAKSISQLEHLTSLNISINGI 59
                67889********************************98865 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 5.6e-05
                SSTT-TT--EEE--SS---GGG CS
       LRR_8 20 aFkglsnLkvLdLsnNllttls 41
                +  +l+nL++Ld+snNll  ++
  EFC38410.1 65 FIGQLKNLTELDISNNLLGDFE 86
                56679***********997765 PP

  == domain 3  score: 28.6 bits;  conditional E-value: 3.9e-10
                 T-SEEE-TTS--SEE-TT.SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltsldde.aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+Ld+snN l + + e + ++l++L++L++s+N+++   ++++s+L++L+ L+++ N +
  EFC38410.1  71 NLTELDISNNLLGDFEGEkSISQLQKLTILNISCNRINDEGAKSLSQLNQLTNLNIRLNEI 131
                 9*************997625666********************************998865 PP

  == domain 4  score: 27.0 bits;  conditional E-value: 1.2e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsg 58 
                 nLt L +++N+++  + +  ++l nLk+L++  N ++++   +a+s ++ Lrs  L++
  EFC38410.1 144 NLTLLTIDHNQIQTQGAKYLSNLVNLKTLYIHGNeNIEREGSKAISEMKELRSVKLDH 201
                 9****************************************************99998 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   2.1   3.5e-06    0.0077       1      33 [.      23      57 ..      23      61 .. 0.81
   2 !   19.9   2.9   3.2e-07   0.00072       2      40 ..      48      86 ..      48      93 .. 0.87
   3 !   26.6   3.0   2.5e-09   5.7e-06       1      38 [.      70     109 ..      70     112 .. 0.86
   4 !   12.8   4.7   5.6e-05      0.12       1      36 [.      95     131 ..      95     139 .. 0.86
   5 !   18.9   2.7   6.8e-07    0.0015       1      36 [.     143     180 ..     143     206 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 3.5e-06
                SS--EEE--SS---E-S-...HHH-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgN 33
                +n ++L L++N++  i++   +++l +L++L++s N
  EFC38410.1 23 KNVTKLTLNHNNIG-IQGaksISQLEHLTSLNISIN 57
                699*********99.777565557********9655 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 3.2e-07
                S--EEE--SS---.E-S-HHH-TT--EEE-.-S-----GG CS
       LRR_4  2 nLevLdLsnNqlt.diplleklpnLkeLdLsgNnlitdld 40
                +L++L++s N +    +++++l+nL+eLd+ +Nnl++d++
  EFC38410.1 48 HLTSLNISINGIYqGAEFIGQLKNLTELDI-SNNLLGDFE 86
                599999997799988888999*********.666**9986 PP

  == domain 3  score: 26.6 bits;  conditional E-value: 2.5e-09
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlitd 38 
                 +nL++Ld+snN l d+++   +++l +L+ L++ ++n+i+d
  EFC38410.1  70 KNLTELDISNNLLGDFEGeksISQLQKLTILNI-SCNRIND 109
                 79****************765447*********.6668865 PP

  == domain 4  score: 12.8 bits;  conditional E-value: 5.6e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L++s N++ d +   l++l +L+ L++ + n i
  EFC38410.1  95 QKLTILNISCNRINDEGAksLSQLNQLTNLNI-RLNEI 131
                 69*******99****99998889********9.64455 PP

  == domain 5  score: 18.9 bits;  conditional E-value: 6.8e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +nL+ L + +Nq+++ +   l++l nLk+L+++gN +i
  EFC38410.1 143 QNLTLLTIDHNQIQTQGAkyLSNLVNLKTLYIHGNENI 180
                 69*************99999889*********999555 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.6      0.24   5.5e+02       3      15 ..      26      38 ..      24      62 .. 0.63
   2 !    9.5   0.2   0.00076       1.7       1      15 [.      71      85 ..      71      94 .. 0.85
   3 !    7.4   0.2    0.0036       8.1       1      22 [.      96     117 ..      96     118 .. 0.88
   4 ?    0.1   0.0       0.9     2e+03       2      18 ..     121     137 ..     120     142 .. 0.74
   5 ?    2.0   0.1      0.22   4.9e+02       1      22 [.     144     165 ..     144     166 .. 0.78
   6 !    6.5   0.0    0.0071        16       1      17 [.     168     185 ..     168     191 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.24
       LRR_1  3 rhLdLsnnpllgl 15
                ++L L++n+++  
  EFC38410.1 26 TKLTLNHNNIGIQ 38
                6777888887322 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00076
       LRR_1  1 nLrhLdLsnnpllgl 15
                nL++Ld+snn l+++
  EFC38410.1 71 NLTELDISNNLLGDF 85
                8*********99554 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0036
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L+ L++s n++ + ++ s++ 
  EFC38410.1  96 KLTILNISCNRINDEGAKSLSQ 117
                 79**********9999999876 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.9
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L+ L+++ n +++ ++ 
  EFC38410.1 121 LTNLNIRLNEIGDEGAK 137
                 889***99998776655 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.22
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL+ L + +n++   ++ +++n
  EFC38410.1 144 NLTLLTIDHNQIQTQGAKYLSN 165
                 8999******997666666665 PP

  == domain 6  score: 6.5 bits;  conditional E-value: 0.0071
       LRR_1   1 nLrhLdLsnnpl.lglpp 17 
                 nL++L++ +n + ++ ++
  EFC38410.1 168 NLKTLYIHGNENiEREGS 185
                 8******99997455555 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   1.8   8.6e-05      0.19      53     127 ..      36     109 ..      25     126 .. 0.80
   2 !    9.1   0.9   0.00037      0.84      62     131 ..     114     185 ..     101     209 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.6e-05
       LRR_9  53 dirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                  i+   ++  l+ l +l ++ n i + ae +++ l nl+el ++nn l ++   + + +l+kl++l +  n + +
  EFC38410.1  36 GIQGAKSISQLEHLTSLNISINGIYQGAEFIGQ-LKNLTELDISNNLLGDFEGEKSISQLQKLTILNISCNRIND 109
                 4566778889999*************9999987.79***********9999998999999999999887777655 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00037
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleel...vltnnelqeladldPlaslkklellsllknpvtnkkey 131
                  l +l+ l   n r+  i+++ ++++ ++++l    + +n++q  +  + l +l +l++l +  n  ++++  
  EFC38410.1 114 SLSQLNQLTNLNIRLNEIGDEGAKFIGKMQNLtllTIDHNQIQTQGA-KYLSNLVNLKTLYIHGNENIEREGS 185
                 45556666666666666666666666555554100445677777666.7788888888887777766655543 PP

>> NKWYS  Putative capsular polysaccharide synthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.3   0.00065       1.5       9      97 ..      35     127 ..      27     131 .. 0.77
   2 !   11.9   1.0   7.9e-05      0.18      41     129 ..     118     206 ..     115     211 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00065
       NKWYS   9 lkidmertyqlLeeiFekyinkn..lpaeWFDnElkknlgiDvfnkdfdkdegfv.ifnnkkfsllliksekldel.dkeikdfLnidnvklk 97 
                 + i+  +++  Le++   +i+ n  +    F   lk+++ +D+ n+ + + eg + i + +k  +l i ++++++   k++ ++  + n++++
  EFC38410.1  35 IGIQGAKSISQLEHLTSLNISINgiYQGAEFIGQLKNLTELDISNNLLGDFEGEKsISQLQKLTILNISCNRINDEgAKSLSQLNQLTNLNIR 127
                 5556677788888877666554422777789999************9999998761556699**********999878888888777888775 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 7.9e-05
       NKWYS  41 lkknlgiDvfnkdfdkdegfvifnnkkfsllliksekldel.dkeikdfLnidnvklkksneaknKwYseiysefkdkydfskelleeml 129
                 l++++ +++  +++ ++   +i + ++  ll i +++++ +  k++ +++n++ + + + ne  ++  s+ +se+k+  +++ + ++ ++
  EFC38410.1 118 LNQLTNLNIRLNEIGDEGAKFIGKMQNLTLLTIDHNQIQTQgAKYLSNLVNLKTLYI-HGNENIEREGSKAISEMKELRSVKLDHIHILY 206
                 889999999999999999999999**************9999**********99887.67888899999999999999988888887666 PP

>> DUF5471  Family of unknown function (DUF5471)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.2      0.82   1.8e+03       6      25 ..      13      32 ..      10      35 .. 0.83
   2 ?   11.3   0.0   0.00014      0.31      13      48 ..      97     135 ..      85     144 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.82
     DUF5471  6 kklGqllvrmynveakrlnd 25
                kkl   l +m nv    ln 
  EFC38410.1 13 KKLVESLRKMKNVTKLTLNH 32
                89999999999998888875 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00014
     DUF5471  13 vrmynveakrlndearkeatqs...ralairsneladsa 48 
                 + + n+   r+nde  k  +q      l ir ne+ d  
  EFC38410.1  97 LTILNISCNRINDEGAKSLSQLnqlTNLNIRLNEIGDEG 135
                 3578************9887651115789******9965 PP

>> DUF424  Protein of unknown function (DUF424)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1      0.28   6.3e+02      29      58 ..      28      54 ..      12      63 .. 0.76
   2 ?    8.3   0.1    0.0012       2.8      27      58 ..      73     102 ..      69     109 .. 0.89
   3 ?    0.8   0.1      0.27     6e+02      54      58 ..     122     126 ..     104     205 .. 0.61

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.28
                EE--HHHH--EEE-HHHHHHHHHHHEEEEE CS
      DUF424 29 lnvsegfyggelaseeeaikeLekatiaNi 58
                l+++   +g + a   ++i++Le +t  Ni
  EFC38410.1 28 LTLNHNNIGIQGA---KSISQLEHLTSLNI 54
                5555555555555...89999999999998 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0012
                 EEEE--HHHH--EEE-HHHHHHHHHHHEEEEE CS
      DUF424  27 lllnvsegfyggelaseeeaikeLekatiaNi 58 
                 ++l +s+ + g      e++i++L+k+ti Ni
  EFC38410.1  73 TELDISNNLLGDFEG--EKSISQLQKLTILNI 102
                 678899999999999..**************9 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.27
                 EEEEE CS
      DUF424  54 tiaNi 58 
                 t+ Ni
  EFC38410.1 122 TNLNI 126
                 55554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       555  (0.0309554); expected 358.6 (0.02)
Passed bias filter:                      254  (0.014167); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1260.04
//
Query:       EFC38411.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.076   13.2   3.0       0.17   12.1   3.0    1.7  1  HALZ      Homeobox associated leucine zipper


Domain annotation for each model (and alignments):
>> HALZ  Homeobox associated leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   3.0   9.7e-06      0.17      19      41 ..     371     393 .]     368     393 .] 0.89

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.7e-06
        HALZ  19 sdydsLkkenekLkaelqeLkek 41 
                 ++ ++L+kene+Lk e+++Lk+k
  EFC38411.1 371 MQTQQLLKENEELKREIERLKKK 393
                 56789****************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1701  (0.0948742); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2321.43
//
Query:       EFC38412.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       516  (0.0287802); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.33s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1118.57
//
Query:       EFC38413.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-06   28.2   0.8      1e-05   25.7   0.1    2.3  2  BTB       BTB/POZ domain
  ------ inclusion threshold ------
      0.025   14.3   4.5      0.037   13.8   0.1    2.6  2  DUF2247   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1     0.096   8.6e+02      48      98 ..      82     130 ..      47     133 .. 0.57
   2 !   25.7   0.1   1.2e-09     1e-05       1      49 [.     249     295 ..     249     304 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.096
                 TCCCEEEEE.TTSGHHHHHHHHH.HHHHSEEEC-CGGGHHHHHHHHHHHT-HH CS
         BTB  48 essvseiel.ddvepeafealLe.fiYtgeleitseenleelLaaadllqipr 98 
                 e++   + + ++   e+++ l++  iY ++ +   + n  + L++   l + +
  EFC38413.1  82 EHN---LSImEEEYLEIVQHLVDqLIYKEHADKY-WRNYYSALQILYVLGLSA 130
                 222...2330333347788888624588888884.888888888877777655 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 1.2e-09
                 HHHHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTSTTTTTC CS
         BTB   1 lnelresgelcDvtlvvgdgkefkahkavLaarSpyFkalftskeiees 49 
                 l++l ++++ +Dv + +g + ++ +hk vLa++S+ F+  f+++   +s
  EFC38413.1 249 LKKLYNQESTSDVKIILGSKLSLNCHKTVLASSSSHFRIWFEKN--FDS 295
                 68999*************************************99..333 PP

>> DUF2247  Uncharacterized protein conserved in bacteria (DUF2247)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   1.3     0.039   3.5e+02      82     108 ..     154     180 ..      52     201 .. 0.67
   2 ?   13.8   0.1   4.1e-06     0.037      16      79 ..     201     263 ..     198     266 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.039
     DUF2247  82 rkwlyvvLkelkelskdfeepLeevee 108
                  k l+v+ ++++ l+++f e++++v+ 
  EFC38413.1 154 VKNLVVMFEKIDGLQQNFIENFNKVNY 180
                 344566667777777777777777775 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 4.1e-06
     DUF2247  16 yvGleknlisadevieyaekllekgeaseelileLafleekeeeelknllkklaseekkideel 79 
                 +vG++k+l++   +i    k++ k +  + + ++L  ++ k   ++ + lkkl+++e+++d ++
  EFC38413.1 201 KVGCSKKLLDSPIIIRNYAKIMAKVNLTKPTQIKL-TCNDKLPSSILQALKKLYNQESTSDVKI 263
                 69*************99999***************.88888889999999******99999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1014  (0.0565564); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2007.75
//
Query:       EFC38414.1  [L=175]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.9e-09   35.8  80.0    2.9e-05   24.0  34.6    2.9  3  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2  37.4   8.9e-07     0.016      59     113 ..       4      58 ..       1      63 [. 0.55
   2 !   10.0  24.5   3.6e-05      0.64      59     111 ..      42     100 ..      39     102 .. 0.45
   3 !   24.0  34.6   1.6e-09   2.9e-05      49     111 ..      72     134 ..      62     162 .. 0.43

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 8.9e-07
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepepga 113
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p +
   EFC38414.1   4 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKT 58 
                  4455555555555555555555566666666666666666666666666666655 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 3.6e-05
  Trypan_PARP  59 pepepepepepepepepepep......etepeeepepepepepepepepepepepepep 111
                  p+p+p+p+p+p+p+p+++ +       +t+ + +++ +++p+p+p+p+p+p+p+p+p+p
   EFC38414.1  42 PKPKPKPKPKPKPKPKTQTQTqtqtqtQTQTQTQTQTQTQPKPKPKPKPKPKPKPKPKP 100
                  33444444444444443333355565434444444555555555555555555555555 PP

  == domain 3  score: 24.0 bits;  conditional E-value: 1.6e-09
  Trypan_PARP  49 vsdddtngtdpepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                   + +    t+p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC38414.1  72 TQTQTQTQTQPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 134
                  333333444444444444444444444444433333333332222222222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1285  (0.0716716); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                       108  (0.00602376); expected 17.9 (0.001)
Passed Fwd filter:                        53  (0.0029561); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.08u 0.38s 00:00:01.46 Elapsed: 00:00:00.62
# Mc/sec: 853.32
//
Query:       EFC38415.1  [L=183]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0023   16.9   0.0     0.0046   15.9   0.0    1.4  2  Aminotran_5     Aminotransferase class-V
  ------ inclusion threshold ------
       0.11   11.2   0.2       0.12   11.1   0.2    1.2  1  Folate_carrier  Reduced folate carrier
       0.13   12.3   1.0         12    5.9   0.3    2.1  2  SPOUT_MTase     Predicted SPOUT methyltransferase
       0.16   11.7   6.0        0.2   11.3   6.0    1.1  1  GET2            GET complex subunit GET2


Domain annotation for each model (and alignments):
>> Aminotran_5  Aminotransferase class-V
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0      0.68     3e+03       2      11 ..      55      64 ..      28      83 .. 0.60
   2 !   15.9   0.0     1e-06    0.0046     183     221 ..     125     164 ..     120     181 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.68
                 EEBTTTS--- CS
  Aminotran_5  2 yldsaAttqk 11
                  ld a++t +
   EFC38415.1 55 HLDHAGSTLT 64
                 3444444444 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 1e-06
                  S---HHHHTESEEEEETTTTTS.STT-EEEEEEHHHHHTS CS
  Aminotran_5 183 ipidvkklgvDflafsghKllg.PtGiGvlyvrkellekl 221
                    id++k++ Df+++s  K +g PtG+G+l +rk  + k+
   EFC38415.1 125 VSIDLSKYKPDFIVASLYKWFGyPTGLGILLIRKIRISKI 164
                  579****************6666**********9666665 PP

>> Folate_carrier  Reduced folate carrier
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   2.6e-05      0.12     167     228 ..      55     115 ..       7     155 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 2.6e-05
  Folate_carrier 167 slasvvvalllslfLprpkkslffkkkeaaskkdekseeeseeseeeenekeeeeekssees 228
                      l     +l+ s +L+++ ++lff +++ + ++de++e++  + ++  n++++++++++ + 
      EFC38415.1  55 HLDHAGSTLTSSKCLKKAFEQLFFPNNNDNNNEDETNETND-NDDTLINNNNNNNNTMKYDH 115
                     555666689999************99944444444433333.33322222222222222222 PP

>> SPOUT_MTase  Predicted SPOUT methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0    0.0034        15      45      84 ..      28      68 ..       5      78 .. 0.75
   2 ?    5.9   0.3    0.0026        12      41      91 ..      82     132 ..      67     141 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0034
                 -S-HHHHHHHHHHT--.....TT-EEEEE-TTSEE--HHHH CS
  SPOUT_MTase 45 ekeeekakekegeril.kklkkkayvillderGkelsSeel 84
                 ++ ++++ + e er+  + +++++ ++ ld  G++l+S + 
   EFC38415.1 28 TTATTRTYDVEMERMRrDYFNHDESIVHLDHAGSTLTSSKC 68
                 5566677778888888557789999***********99875 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0026
                  ..---S-HHHHHHHHHHT--....TT-EEEEE-TTSEE--HHHHHHHHHHH CS
  SPOUT_MTase  41 ekksekeeekakekegerilkklkkkayvillderGkelsSeelakklekl 91 
                  +++++++e++  +++ ++++++ ++++ ++  d + +++sS++ +  l+k 
   EFC38415.1  82 NDNNNEDETNETNDNDDTLINNNNNNNNTMKYDHNTSKYSSTNVSIDLSKY 132
                  23335666666666677888899999****************999888775 PP

>> GET2  GET complex subunit GET2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   6.0   4.5e-05       0.2      41     172 ..      11     131 ..       2     145 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 4.5e-05
        GET2  41 sttsvLdepaaekttpasttasssssasehddpeiediseiavkpkktasskkksplseesepeapqldqllkqllqqqqqgnsensqdaesstPdlfs 139
                 ++   L +++++    +stt+++++++    d e+e + +  +++   +s  + +++ + ++++ + l++ ++ql+ ++  +n++n++d+++ t d ++
  EFC38415.1  11 EE-QSLGSSSSS---ITSTTTTTATTR--TYDVEMERMRRDYFNHD--ESIVHLDHAGSTLTSS-KCLKKAFEQLFFPN--NNDNNNEDETNETNDNDD 98 
                 22.334422222...222223333333..36888877776666553..3344455556655555.48999******995..55556666777889**** PP

        GET2 140 qllkmmkqgeggsakseeetssspeeaeyqqql 172
                  l+++ +++++++++++++++ s+ + +++ + 
  EFC38415.1  99 TLINNNNNNNNTMKYDHNTSKYSSTNVSIDLSK 131
                 ********9999777777666666655555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1709  (0.0953204); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.56
# Mc/sec: 992.33
//
Query:       EFC38416.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-21   75.2   0.0    6.8e-21   74.6   0.0    1.2  1  MOSC      MOSC domain


Domain annotation for each model (and alignments):
>> MOSC  MOSC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.6   0.0   3.8e-25   6.8e-21       8     118 ..     110     218 ..     106     228 .. 0.92

  Alignments for each domain:
  == domain 1  score: 74.6 bits;  conditional E-value: 3.8e-25
                 GGGSEEEEETHHHHHHHHHS..GGG..GG-STTTT--SEEES-.......-TTT-BTT-E.EEETT................EE----THHHHHTTHHH CS
        MOSC   8 dekavllisresldalneelkegrs..veldpgrfreNivvggaaafeEdtwkelrigdrrfrlggacsRcqmvnvdqetgarprepcktlakfrrvdk 104
                 ++  +l+ +++sl +ln++l+ ++    e+ + r+r+Niv++g +++eEd+ k++ i++  f++ ++csRc+m++++++t  + +ep++tl ++rr+  
  EFC38416.1 110 NKGLFLVLNKSSLIDLNKRLGLNDItnIEWLIDRMRPNIVIEGLEEYEEDEIKSIYINNIPFQINSQCSRCTMICINPNTLIQEEEPLRTLYSYRRFG- 207
                 666789**************5554499899999********998****************************************************98. PP

                 HHHHHT---EEEEE CS
        MOSC 105 rvkgkgrfGvylrv 118
                    + ++fGvy+++
  EFC38416.1 208 ---NGVLFGVYASP 218
                 ...99******986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       940  (0.052429); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.27s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1693.12
//
Query:       EFC38417.1  [L=239]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.064   13.4   0.2       0.12   12.5   0.2    1.5  1  Dicer_dimer  Dicer dimerisation domain
        3.1    7.4  19.8      0.028   14.1  10.9    1.8  2  BSP_II       Bone sialoprotein II (BSP-II)


Domain annotation for each model (and alignments):
>> Dicer_dimer  Dicer dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.2   1.4e-05      0.12      32      87 ..     153     215 ..     123     220 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.4e-05
  Dicer_dimer  32 k.....ergkfqaevtLPsnspl.rkiegepmst.kklAkrsaAfeackeLhkaglLddhLlP 87 
                  k     +++k   +   P++     +i+++p s+   +Akrs  + +  +L +++lLd+h  P
   EFC38417.1 153 KlivlaNNNKHNSQSSTPMSFMKsSSIYSKPTSNaTSRAKRSSSLSTPTQLNNHQLLDKHSPP 215
                  13444478888889999999996699***666651678*********************9776 PP

>> BSP_II  Bone sialoprotein II (BSP-II)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1  10.9   3.1e-06     0.028     140     216 ..      26      98 ..      16     113 .. 0.64
   2 ?   -1.7   1.5       0.2   1.8e+03     182     225 ..     159     202 ..     137     239 .] 0.41

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 3.1e-06
      BSP_II 140 eeeeeeeeneeeeaevdeneqgvngtstnsteaengngssggdngeeeeeesvteaeaegteveeeeeagsaettts 216
                 e++++e+e+ee  ++ d n+++    + ns   e+ n+s+ gd+  eeeee + e+  e+ +++++  ags +t+t+
  EFC38417.1  26 ENDDNEREEEE-FNNLDRNDNTYLNVDENSII-ESCNASTCGDEYKEEEEETIVEE--EEIQSDDDDGAGSPTTSTK 98 
                 33333233333.3589********9***9997.66889999899555566665553..3444444444444444443 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.2
      BSP_II 182 dngeeeeeesvteaeaegteveeeeeagsaetttspnglfeatt 225
                 +n+  + + s   +  + ++  ++ ++++++ +  +++l ++t 
  EFC38417.1 159 NNNKHNSQSSTPMSFMKSSSIYSKPTSNATSRAKRSSSLSTPTQ 202
                 33333333333333333444444444444444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1230  (0.0686039); expected 358.6 (0.02)
Passed bias filter:                      272  (0.015171); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.33s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1369.88
//
Query:       EFC38418.1  [L=488]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.2e-19   70.8   3.6    1.6e-19   70.4   0.1    2.3  2  DUF5578       Family of unknown function (DUF5578)
     0.0089   15.6   0.3     0.0089   15.6   0.3    2.1  2  Peptidase_M1  Peptidase family M1 domain
  ------ inclusion threshold ------
      0.056   12.1  14.7      0.073   11.7  14.7    1.1  1  Hamartin      Hamartin protein


Domain annotation for each model (and alignments):
>> DUF5578  Family of unknown function (DUF5578)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.4   0.1   2.7e-23   1.6e-19      76     204 ..       4     132 ..       1     170 [. 0.84
   2 ?    0.9   0.5     0.042   2.5e+02     217     259 ..     326     368 ..     298     374 .. 0.73

  Alignments for each domain:
  == domain 1  score: 70.4 bits;  conditional E-value: 2.7e-23
     DUF5578  76 lekqlkaigiflsaasgkrylieFlEiGGvltlleilglkqlk..eedkaealkllqlvanaGrkyKEliCEsygvravaeclakskseetqeeaqkll 172
                 l+ q+k ig+f+    g + l+eF+EiGG  +lle+lg +  k  +edk+eal ll+ +an GrkyKE+iC   g+  + + +    s   +  a++++
  EFC38418.1   4 LAIQIKCIGLFIQ---GYKPLLEFIEIGGTQILLEVLGFHYYKneNEDKKEALLLLTNIANNGRKYKEVICFDNGLDLLRNSIIYIPSIDINLIAKNFI 99 
                 7789999999985...7899*****************98865521689*************************************************** PP

     DUF5578 173 eslaegnPkyqkqvykgliallacs.spkaqql 204
                  s+ +gnPk+++ + + l  +   + sp+  + 
  EFC38418.1 100 VSIYQGNPKHSNDILELLFDIFRNHsSPNNWKT 132
                 ***************999998876635555444 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.042
     DUF5578 217 keakpsivepllelLkslhlevqyeaielikelmstevraall 259
                 +  ++ + + +   L+  ++ v  e++e++k  m++  ++++ 
  EFC38418.1 326 QMRETRVLDIIFMNLSDEDIRVVRESVEMVKIAMQYPDENEIF 368
                 33447789999999*****************999997666665 PP

>> Peptidase_M1  Peptidase family M1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.6      0.14   8.4e+02      98     153 ..     243     297 ..     242     330 .. 0.60
   2 !   15.6   0.3   1.5e-06    0.0089     109     199 ..     317     413 ..     307     421 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.14
                   HHHHHHHHHHHHHSCCCHCHHHHHHHCHHHHHHHHTSTTHHHSSGG-GSHHHHHHT CS
  Peptidase_M1  98 fatyleylildklepewevseqllleeveealsedaldeshpitqevekpseidev 153
                   f+++   ++++ + ++    e++  ++   ++ ++ +++s++ +++ ++++++++ 
    EFC38418.1 243 FTKFTFLNVVETARNQLASAEEF-RKSFDPSNTNNNMNNSNNTNTNNTNNTNTNDN 297
                   67777777777777777766666.55555566666666666555433333333332 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 1.5e-06
                   HHSCCCH...CHHHHHHHCHHHHHHHHTSTT.HHHSS..GG-GSHHHHHHTSSHHHHHHHHHHHHHHHHHCTHHHHHHHHHHHHHHCTTEEE-HHHH CS
  Peptidase_M1 109 klepewe...vseqllleeveealsedalde.shpit..qevekpseidevFdsiaYeKGasllrmlekllgeevFqkglksYlkefkyknaetedl 199
                   +++++ +   ++e+ +l+ + ++ls++ ++  +++++  +   +  + +e+F+++  +++++ l+m+  +lg+  F++ lk+++k+ +y n ++e++
    EFC38418.1 317 EISKSIKieqMRETRVLDIIFMNLSDEDIRVvRESVEmvKIAMQYPDENEIFSEMLIHRSIQGLSMIVIVLGKRRFKTILKQFFKNSNYLNNSKEEI 413
                   4444333334666667777777777766666344555323333456889*************************************99998887765 PP

>> Hamartin  Hamartin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7  14.7   1.2e-05     0.073     283     457 ..     131     317 ..     104     369 .. 0.52

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.2e-05
    Hamartin 283 dlqsstgsststpistkrlql.sslsgtspavlsvessrskddeislWSPssvcgmttppsspgivpttelelsssasllsskvsstpeaagkatpe.t 379
                 ++ s++ ss+ tp   +  +l  + s++++++++ e++  ++  + + SP ++    ++p +p ++  t++   +s+   s++v++ p++++  +p  t
  EFC38418.1 131 KTISAHLSSNNTPRRNSTINLlDNNSQQQQQTQQQEMNAFSSPRSIFNSPRVFGNFLMSPRTPNVAHITNT-TTNSTTATSKNVIQSPSSSISFQPGlT 228
                 33455555555554444444403333333333333333333333467999999999999999987777663.455555555666777777799999889 PP

    Hamartin 380 TPakssrklppslsesavv......valpassrksspprkdeksesskpdlskqeevenekeleeslk.skssvtlse.....Lsdvike 457
                 TP +     ++sl+  +        +a ++ + ++   rk+  +++++ +++ +++++++++ + +++ + +s++ls      + ++ike
  EFC38418.1 229 TPKNEATPKQQSLPFTKFTflnvveTARNQLA-SAEEFRKSFDPSNTNNNMNNSNNTNTNNTNNTNTNdNANSIELSTqsillIYSMIKE 317
                 99887764433333333333332211111111.222233333334444445555555333333222222444444443344432233332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1854  (0.103408); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 3229.11
//
Query:       EFC38419.1  [L=1296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2313  (0.129009); expected 358.6 (0.02)
Passed bias filter:                      368  (0.0205254); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        29  (0.00161749); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.50u 0.38s 00:00:01.88 Elapsed: 00:00:00.62
# Mc/sec: 6292.73
//
Query:       EFC38420.1  [L=114]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      1e-08   34.9   0.3    1.7e-08   34.2   0.3    1.4  1  LRR_9            Leucine-rich repeat
    0.00015   22.1   3.3     0.0016   18.8   0.5    2.7  3  LRR_4            Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
       0.14   11.9   1.7        2.7    7.8   0.9    2.7  2  LRR_8            Leucine rich repeat
       0.16   11.9   0.0       0.19   11.7   0.0    1.1  1  Glyco_tran_WecB  Glycosyl transferase WecB/TagA/CpsF family


Domain annotation for each model (and alignments):
>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.2   0.3   3.8e-12   1.7e-08      85     164 ..       3      94 ..       1     105 [. 0.80

  Alignments for each domain:
  == domain 1  score: 34.2 bits;  conditional E-value: 3.8e-12
       LRR_9  85 evlPnleelvltnnelqeladldPlasl..kklellsllknpvtnk..........keyrlyviyklkqlrlldfrkvklkereeaeklfks 164
                 + lPnle l +++n++++l+ +   +++  ++l+++s++ n  + +          ++yr++vi +l++l++ld + v  +er++a + +  
  EFC38420.1   3 KPLPNLELLWVNSNNITNLSAFIERVKVvcPNLQYFSMMANKACPNffvggtpelyQDYRHFVISRLPKLKVLDQNNVTDEERQQALQHYAN 94 
                 679****************986544443239*********988753333333334489****************************998866 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.5   3.6e-07    0.0016       1      33 [.       6      43 ..       6      48 .. 0.86
   2 ?    2.8   0.1     0.038   1.7e+02      22      29 ..      69      76 ..      59      82 .. 0.75
   3 ?    0.5   0.1      0.21   9.3e+02       6      15 ..      75      82 ..      70      96 .. 0.60

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 3.6e-07
                SS--EEE--SS---E-S-HH.....H-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnNqltdiplle.....klpnLkeLdLsgN 33
                pnLe L+ ++N++t ++ +       +pnL+++++  N
  EFC38420.1  6 PNLELLWVNSNNITNLSAFIervkvVCPNLQYFSMMAN 43
                8*****************66688866*******99445 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.038
                -TT--EEE CS
       LRR_4 22 lpnLkeLd 29
                lp+Lk+Ld
  EFC38420.1 69 LPKLKVLD 76
                99999997 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.21
                EE--SS---E CS
       LRR_4  6 LdLsnNqltd 15
                Ld  +N++td
  EFC38420.1 75 LD--QNNVTD 82
                32..344555 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.9   0.00059       2.7      24      44 ..       5      23 ..       2      44 .. 0.78
   2 ?    2.2   0.0     0.034   1.5e+02      21      31 ..      66      76 ..      59      97 .. 0.69

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00059
                -TT--EEE--SS---GGGGGG CS
       LRR_8 24 lsnLkvLdLsnNllttlspga 44
                l+nL+ L  ++N++t ls  a
  EFC38420.1  5 LPNLELLWVNSNNITNLS--A 23
                889999999999999987..4 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.034
                STT-TT--EEE CS
       LRR_8 21 FkglsnLkvLd 31
                 ++l++LkvLd
  EFC38420.1 66 ISRLPKLKVLD 76
                56778888876 PP

>> Glyco_tran_WecB  Glycosyl transferase WecB/TagA/CpsF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   4.2e-05      0.19      35      94 ..      36      94 ..      10     101 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.2e-05
  Glyco_tran_WecB 35 elleraeeeglrvfllGgkpevlekaaerlrekypglriagthdgykeeeeeaiieaina 94
                     + ++ ++++  + f++Gg+pe  +  ++ + +++p+l++   ++   +ee ++ +++ ++
       EFC38420.1 36 QYFSMMANKACPNFFVGGTPELYQDYRHFVISRLPKLKVLDQNNVT-DEERQQALQHYAN 94
                     3444445556999**************************9987775.6777777776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       650  (0.0362541); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.44u 0.28s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 772.36
//
Query:       EFC38421.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.014   14.4   0.5      0.019   14.0   0.5    1.1  1  MT          Microtubule-binding stalk of dynein motor
      0.089   13.1   3.2        0.4   11.0   3.6    1.9  2  DUF4061     Domain of unknown function (DUF4061)
       0.14   12.8   0.5       0.62   10.7   0.3    2.1  2  DUF883      Bacterial protein of unknown function (DUF883)
       0.17    9.8   2.7       0.23    9.4   2.7    1.1  1  Prominin    Prominin
       0.21   12.2   5.2       0.52   11.0   3.0    2.2  2  YabA        Initiation control protein YabA
       0.32   10.4   6.4       0.64    9.4   6.4    1.4  1  DUF3552     Domain of unknown function (DUF3552)
        2.8    5.8   7.9        1.3    6.9   5.4    1.5  1  V_ATPase_I  V-type ATPase 116kDa subunit family
        5.5    6.2  10.6        8.8    5.6  10.6    1.4  1  FAM76       FAM76 protein


Domain annotation for each model (and alignments):
>> MT  Microtubule-binding stalk of dynein motor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.5   8.5e-06     0.019      13      74 ..     220     285 ..     211     306 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 8.5e-06
          MT  13 taaqvddl...kaklaaqevelkqknedadkliqvvgvetekvskek.aiadeeekkvavinkevk 74 
                 + ++ d+l     k+  q   lkqk+e+  kl q + vet++v ke   i  ++ kkv+ i + + 
  EFC38421.1 220 SRTNSDNLsigEDKMKNQLDYLKQKQEQLYKLNQQLNVETKQVLKETdDIVKQQSKKVESISSRIP 285
                 455555552224588899999************************963799********9998775 PP

>> DUF4061  Domain of unknown function (DUF4061)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       2.3   5.2e+03      34      74 ..     185     225 ..     169     228 .. 0.64
   2 ?   11.0   3.6   0.00018       0.4      24      76 ..     228     280 ..     223     286 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.3
     DUF4061  34 leeiReqQekLarlhfeldaeeeelaekeedalresdenlk 74 
                 l++  eq + + r +++l+a ++ +++++  +l++s++n +
  EFC38421.1 185 LHDSPEQNNVVPRPKLSLGAVSRYTDDDDVRSLTSSRTNSD 225
                 55555677777777888888888888777777776666544 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00018
     DUF4061  24 afGkdcsleqleeiReqQekLarlhfeldaeeeelaekeedalresdenlkkL 76 
                 ++G+d   +ql+ ++++Qe+L +l+ +l++e+++  ++++d +++++++++++
  EFC38421.1 228 SIGEDKMKNQLDYLKQKQEQLYKLNQQLNVETKQVLKETDDIVKQQSKKVESI 280
                 57999999*************************99999999998888877765 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.3   0.00028      0.62      37      72 ..     238     273 ..     212     282 .. 0.85
   2 ?   -0.2   0.0       0.7   1.6e+03      12      49 ..     275     312 ..     271     320 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00028
      DUF883  37 eerlerarerlrdaeeavaerakeaaeaaddyVren 72 
                  ++l++ +e+l ++++++  ++k++ +++dd+V+++
  EFC38421.1 238 LDYLKQKQEQLYKLNQQLNVETKQVLKETDDIVKQQ 273
                 4799*****************************987 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.7
      DUF883  12 adleellkeaadeageeaeelRerleerlerarerlrd 49 
                 +++e++ ++  ++  ++a+++R++  ++ +r+  +++ 
  EFC38421.1 275 KKVESISSRIPSRPTSSASTVRSNTPSSTHRSNVSTAT 312
                 78888999999999999999999999998887766655 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   2.7    0.0001      0.23     334     403 ..     236     305 ..     205     319 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0001
    Prominin 334 nlssivkeglarlneipekvknqtaevvpdlkkalakgreqikklakkiprealdavisdle.ntersskt 403
                 n     k++ ++l +++++++ +t++v+++    ++++++++++++++ip++ +++ +  +  nt +s+++
  EFC38421.1 236 NQLDYLKQKQEQLYKLNQQLNVETKQVLKETDDIVKQQSKKVESISSRIPSRPTSSAST-VRsNTPSSTHR 305
                 44456789999**************************************9666665544.44488777776 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.38   8.5e+02      23      65 ..     130     172 ..     125     181 .. 0.75
   2 ?   11.0   3.0   0.00023      0.52      18      66 ..     232     280 ..     220     286 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.38
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXXXXXXXXXXXX CS
        YabA  23 eleelkeelaelleenaeLeleneklrerleeeekkekekkke 65 
                  l++lk ++++++ + + ++   ek+ +  +++++ +++++++
  EFC38421.1 130 ALQQLKPSIQTVIRRKSPMKNTEEKVTHSPQSNSRPSSNSSNK 172
                 6889999999999999999988888888776665555555554 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00023
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXXXXXXXXXXXXX CS
        YabA  18 eelleeleelkeelaelleenaeLeleneklrerleeeekkekekkkel 66 
                 ++++++l+ lk++ ++l++ n++L++e +++ ++ ++  k++++k +++
  EFC38421.1 232 DKMKNQLDYLKQKQEQLYKLNQQLNVETKQVLKETDDIVKQQSKKVESI 280
                 68999***********************999998866666666555544 PP

>> DUF3552  Domain of unknown function (DUF3552)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.4   0.00028      0.64      91     144 ..     231     281 ..     214     284 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00028
     DUF3552  91 eetLdrkeeslekkeesleekekelkqkeqsleekeeeleelveeqrqeLeris 144
                 e++++++ + l++k+e+l + +++l+ +++++    +e +++v++q +++e+is
  EFC38421.1 231 EDKMKNQLDYLKQKQEQLYKLNQQLNVETKQV---LKETDDIVKQQSKKVESIS 281
                 55666666666666666666666655544443...4556666777777777776 PP

>> V_ATPase_I  V-type ATPase 116kDa subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   5.4   0.00056       1.3      66     139 ..     219     294 ..     198     325 .. 0.64

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00056
  V_ATPase_I  66 peekeldeleeelekleeelkelnenleklkkelnel.velkavlekakefleeeeeeeeeeeseeeeee.keeee 139
                 +++++ d+l+   +k++++l  l++++e+l k  ++l ve+k+vl+++++++++++++ e+ +s+  ++  +++++
  EFC38421.1 219 SSRTNSDNLSIGEDKMKNQLDYLKQKQEQLYKLNQQLnVETKQVLKETDDIVKQQSKKVESISSRIPSRPtSSAST 294
                 5566677777788899999999999999998866665389************987443333222222222122221 PP

>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6  10.6    0.0039       8.8     146     259 ..     145     279 ..     130     312 .. 0.56

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0039
       FAM76 146 rskskkkkskskkskkske........kskekkaskkkskkhkkrss..........rlevskle......eek...laeekesnetskksldsnssdh 217
                 +s +k++++k ++s++s++        k +++ ++++    h++ ++                        +++     +++ +n+++ +  + ++ ++
  EFC38421.1 145 KSPMKNTEEKVTHSPQSNSrpssnssnKIRATPTKTTAPVLHDSPEQnnvvprpklsL------GavsrytDDDdvrSLTSSRTNSDNLSIGEDKMKNQ 237
                 3333333333333333333000000003323333333333232222233444442321......02223332223333333444444445778899999 PP

       FAM76 218 lvavtqLkeeiaslkkqleqkdqellekdkkitelkaellek 259
                 l  ++q +e++ +l++ql+   +++l+    i + +++++e+
  EFC38421.1 238 LDYLKQKQEQLYKLNQQLNVETKQVLKETDDIVKQQSKKVES 279
                 999****************99999999999998888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2451  (0.136706); expected 358.6 (0.02)
Passed bias filter:                      714  (0.0398237); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 2135.02
//
Query:       EFC38422.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.8e-25   85.2  14.8    1.1e-07   30.9   0.0    4.9  5  EF-hand_1     EF hand
    6.3e-21   72.9  14.5    6.2e-08   31.8   0.1    4.8  5  EF-hand_5     EF hand
    1.3e-20   71.5  10.3      1e-05   25.0   0.1    4.8  5  EF-hand_6     EF-hand domain
    5.6e-18   65.2  10.8      2e-13   50.6   0.4    3.5  3  EF-hand_7     EF-hand domain pair
    1.1e-14   54.0  13.3      1e-08   34.9   0.1    3.8  4  EF-hand_8     EF-hand domain pair
    1.3e-05   25.4   1.7     0.0031   17.8   0.1    3.0  2  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
    0.00017   21.5   6.5        0.7    9.9   0.0    4.1  4  EF-hand_4     Cytoskeletal-regulatory complex EF hand
     0.0038   17.5   0.2        2.9    8.3   0.0    2.5  2  EF-hand_9     EF-hand domain


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       2.1   4.7e+03       2       9 ..      27      34 ..      24      34 .. 0.67
   2 !   10.1   0.1   0.00022      0.49      14      26 ..      47      59 ..      44      61 .. 0.91
   3 !   27.1   0.9   8.1e-10   1.8e-06       2      26 ..      67      91 ..      66      94 .. 0.91
   4 !   24.7   0.2   4.5e-09     1e-05       2      27 ..     104     129 ..     103     131 .. 0.90
   5 !   30.9   0.0   4.8e-11   1.1e-07       2      28 ..     148     174 ..     147     175 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.1
                HHHHHHHH CS
   EF-hand_1  2 lkeiFref 9 
                ++ei++++
  EFC38422.1 27 MDEIMKLY 34
                57777765 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00022
                SSEEEHHHHHHHH CS
   EF-hand_1 14 dGkIdfeEfkell 26
                dG Id++Efke+l
  EFC38422.1 47 DGVIDKNEFKEAL 59
                9**********97 PP

  == domain 3  score: 27.1 bits;  conditional E-value: 8.1e-10
                HHHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1  2 lkeiFrefDkDgdGkIdfeEfkell 26
                ++++F++fD D+dG+Id  Ef+  l
  EFC38422.1 67 VDRMFSLFDGDNDGTIDVREFICGL 91
                79*******************9776 PP

  == domain 4  score: 24.7 bits;  conditional E-value: 4.5e-09
                 HHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellk 27 
                 lk  Fr++D D+dG I++eE+ +ll+
  EFC38422.1 104 LKFSFRIYDFDKDGCISKEELYKLLE 129
                 7889*****************99986 PP

  == domain 5  score: 30.9 bits;  conditional E-value: 4.8e-11
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 ++  F+e+D+DgdGkI+feE++ l++k
  EFC38422.1 148 VDATFAEADTDGDGKISFEEYRVLVTK 174
                 6889******************99987 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.6   3.6e+03      18      25 .]      13      20 ..      13      20 .. 0.81
   2 !    8.8   0.1   0.00053       1.2      13      23 ..      47      57 ..      46      59 .. 0.90
   3 !   18.8   1.5   3.4e-07   0.00077       2      21 ..      67      87 ..      66      88 .. 0.90
   4 !   20.2   0.1   1.3e-07    0.0003       5      25 .]     108     128 ..     104     128 .. 0.92
   5 !   31.8   0.1   2.8e-11   6.2e-08       2      25 .]     148     172 ..     147     172 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.6
                HHHHHHHH CS
   EF-hand_5 18 keELktlv 25
                k ELk+lv
  EFC38422.1 13 KNELKKLV 20
                57***986 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00053
                SSCE-HHHHHH CS
   EF-hand_5 13 DGkIskeELkt 23
                DG I+k E+k+
  EFC38422.1 47 DGVIDKNEFKE 57
                9********97 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 3.4e-07
                HH.HHHHH-SS-SSCE-HHHH CS
   EF-hand_5  2 kd.tFqaiDlNgDGkIskeEL 21
                +d +F+ +D ++DG+I++ E+
  EFC38422.1 67 VDrMFSLFDGDNDGTIDVREF 87
                5669****************9 PP

  == domain 4  score: 20.2 bits;  conditional E-value: 1.3e-07
                 HHHH-SS-SSCE-HHHHHHHH CS
   EF-hand_5   5 FqaiDlNgDGkIskeELktlv 25 
                 F+  D ++DG IskeEL++l+
  EFC38422.1 108 FRIYDFDKDGCISKEELYKLL 128
                 9*****************985 PP

  == domain 5  score: 31.8 bits;  conditional E-value: 2.8e-11
                 HH.HHHHH-SS-SSCE-HHHHHHHH CS
   EF-hand_5   2 kd.tFqaiDlNgDGkIskeELktlv 25 
                 +d tF ++D++gDGkIs+eE + lv
  EFC38422.1 148 VDaTFAEADTDGDGKISFEEYRVLV 172
                 455*****************99775 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       2.4   5.4e+03      18      27 ..      26      35 ..      24      41 .. 0.74
   2 !   10.4   0.1   0.00023      0.51      12      27 ..      45      60 ..      43      63 .. 0.88
   3 !   23.1   0.4   1.9e-08   4.3e-05       3      27 ..      68      92 ..      66     101 .. 0.91
   4 !   25.0   0.1   4.6e-09     1e-05       2      27 ..     104     129 ..     103     138 .. 0.87
   5 !   16.6   0.0   2.4e-06    0.0053       4      23 ..     150     169 ..     147     180 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.4
   EF-hand_6 18 daeElrkalr 27
                d++E++k++ 
  EFC38422.1 26 DMDEIMKLYE 35
                6788888775 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00023
   EF-hand_6 12 dgdGkidaeElrkalr 27
                ++dG id++E++ al 
  EFC38422.1 45 EDDGVIDKNEFKEALG 60
                68***********996 PP

  == domain 3  score: 23.1 bits;  conditional E-value: 1.9e-08
   EF-hand_6  3 reaFklfDkdgdGkidaeElrkalr 27
                ++ F lfD d+dG+id  E++  l+
  EFC38422.1 68 DRMFSLFDGDNDGTIDVREFICGLS 92
                579*****************99887 PP

  == domain 4  score: 25.0 bits;  conditional E-value: 4.6e-09
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalr 27 
                 l+  F+++D+d+dG+i++eEl k+l 
  EFC38422.1 104 LKFSFRIYDFDKDGCISKEELYKLLE 129
                 5667*******************997 PP

  == domain 5  score: 16.6 bits;  conditional E-value: 2.4e-06
   EF-hand_6   4 eaFklfDkdgdGkidaeElr 23 
                 + F + D+dgdGki++eE r
  EFC38422.1 150 ATFAEADTDGDGKISFEEYR 169
                 6799*************976 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.6    0.0077        17      42      69 ..      26      58 ..      12      60 .. 0.63
   2 !   13.7   0.2   2.8e-05     0.062       6      25 ..      69      88 ..      66      98 .. 0.82
   3 !   50.6   0.4     9e-17     2e-13       1      69 [.     101     171 ..     101     173 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0077
   EF-hand_7 42 sdeelellfkef.....DtdkdGvisfdEFlkl 69
                + +e+ +l + f        +dGvi+ +EF+++
  EFC38422.1 26 DMDEIMKLYEQFisissSREDDGVIDKNEFKEA 58
                444555555555566655667899999999886 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2.8e-05
   EF-hand_7  6 eaFkelDtdgdgyldkeell 25
                ++F ++D d+dg +d++e+ 
  EFC38422.1 69 RMFSLFDGDNDGTIDVREFI 88
                67999999999999999964 PP

  == domain 3  score: 50.6 bits;  conditional E-value: 9e-17
   EF-hand_7   1 eeklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdee.....lellfkefDtdkdGvisfdEFlkl 69 
                 +eklk  F+ +D d+dg ++keel +ll++    ++ g +   +e     +++ f e Dtd+dG+isf+E++ l
  EFC38422.1 101 DEKLKFSFRIYDFDKDGCISKEELYKLLEASLVENSLGIP---QEqlsslVDATFAEADTDGDGKISFEEYRVL 171
                 589********************99988864322244444...2224577*********************876 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1         3   6.6e+03      32      38 ..      22      28 ..      20      29 .. 0.79
   2 !   22.9   3.1   2.5e-08   5.6e-05       2      49 ..      47      88 ..      46      91 .. 0.90
   3 !   12.6   0.1   4.2e-05     0.095      32      53 ..     108     129 ..      97     131 .. 0.88
   4 !   34.9   0.1   4.4e-12     1e-08       2      54 ..     116     174 ..     115     175 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3
   EF-hand_8 32 frefDtd 38
                + +fD+d
  EFC38422.1 22 ITHFDMD 28
                6799999 PP

  == domain 2  score: 22.9 bits;  conditional E-value: 2.5e-08
   EF-hand_8  2 kgkItreelrrilrilglkkglseee.vdilfrefDtdgdGkisfeEFc 49
                +g+I++ e++++l   glk    ++  vd +f++fD d+dG+i+  EF+
  EFC38422.1 47 DGVIDKNEFKEAL---GLK----DSLfVDRMFSLFDGDNDGTIDVREFI 88
                8**********88...855....6666*********************7 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 4.2e-05
   EF-hand_8  32 frefDtdgdGkisfeEFcvlle 53 
                 fr  D+d+dG is+eE + lle
  EFC38422.1 108 FRIYDFDKDGCISKEELYKLLE 129
                 8899**************9997 PP

  == domain 4  score: 34.9 bits;  conditional E-value: 4.4e-12
   EF-hand_8   2 kgkItreelrril.rilglkk.glseeevdilfr....efDtdgdGkisfeEFcvller 54 
                 +g+I++eel++ l ++l+ +  g+  e++ +l++    e+DtdgdGkisfeE+ vl+++
  EFC38422.1 116 DGCISKEELYKLLeASLVENSlGIPQEQLSSLVDatfaEADTDGDGKISFEEYRVLVTK 174
                 8***************97666888888888886633337****************9875 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.2    0.0099        22      67     111 ..      46      88 ..       4      89 .. 0.71
   2 !   17.8   0.1   1.4e-06    0.0031      52     110 ..     100     168 ..      95     170 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0099
  SPARC_Ca_bdg  67 sdkvlsksELaplraplvklehCikpflescDadkdkkislkEwc 111
                    d+v++k+E ++      k    ++++++  D d+d++i+ +E++
    EFC38422.1  46 DDGVIDKNEFKEALG--LKDSLFVDRMFSLFDGDNDGTIDVREFI 88 
                   677888888877666..5667778899999999999999999985 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 1.4e-06
  SPARC_Ca_bdg  52 ckepvawkFsklDtnsdkvlsksELapl.raplvkl......e...hCikpflescDadkdkkislkEw 110
                   + e++++ F   D ++d+ +sk+EL +l +a+lv++      e   + +++ + ++D+d d+kis +E+
    EFC38422.1 100 IDEKLKFSFRIYDFDKDGCISKEELYKLlEASLVENslgipqEqlsSLVDATFAEADTDGDGKISFEEY 168
                   56899********************87536777654111111311145678899*************98 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.067   1.5e+02      36      67 ..       7      38 ..       6      44 .. 0.83
   2 !    8.4   0.8   0.00088         2      45      69 ..      67      91 ..      29      96 .. 0.78
   3 ?    1.1   0.0      0.17   3.8e+02      42      65 ..     101     124 ..      91     128 .. 0.81
   4 !    9.9   0.0   0.00031       0.7      40      69 ..     139     172 ..     126     187 .. 0.71

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.067
   EF-hand_4 36 knskleedklekiwdladidedgkldfeefci 67
                kn + ++++l+k+ +++  d d+ + + e  i
  EFC38422.1  7 KNKQYRKNELKKLVEITHFDMDEIMKLYEQFI 38
                6889999**************99988655444 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00088
   EF-hand_4 45 lekiwdladidedgkldfeefciam 69
                ++++++l d d+dg++d  ef+  +
  EFC38422.1 67 VDRMFSLFDGDNDGTIDVREFICGL 91
                57899****************8765 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.17
   EF-hand_4  42 edklekiwdladidedgkldfeef 65 
                 ++kl+  + + d d+dg++  ee+
  EFC38422.1 101 DEKLKFSFRIYDFDKDGCISKEEL 124
                 67888889999*******998885 PP

  == domain 4  score: 9.9 bits;  conditional E-value: 0.00031
   EF-hand_4  40 leedkleki....wdladidedgkldfeefciam 69 
                 +++++l+++    +  ad d dgk+ fee+ + +
  EFC38422.1 139 IPQEQLSSLvdatFAEADTDGDGKISFEEYRVLV 172
                 56666666511114569************98865 PP

>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0028       6.3       1      32 [.      68      99 ..      68     106 .. 0.79
   2 !    8.3   0.0    0.0013       2.9       3      61 ..     107     171 ..     105     175 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0028
   EF-hand_9  1 etvFevcDtqktGrVpvsrlidyLravtaqdp 32
                +++F+++D +  G++ v + i  L    ++ +
  EFC38422.1 68 DRMFSLFDGDNDGTIDVREFICGLSVFCEKGT 99
                689**************999877766665555 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0013
   EF-hand_9   3 vFevcDtqktGrVpvsrlidyLravtaq....dpees...eLeelakelDPdgedasvdldtflrv 61 
                  F+++D +k G +   +l ++L+a   +     p+e     ++   +e+D dg  +++ ++ + + 
  EFC38422.1 107 SFRIYDFDKDGCISKEELYKLLEASLVEnslgIPQEQlssLVDATFAEADTDGD-GKISFEEYRVL 171
                 59*********************9765545557898877677888899999998.99999999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       667  (0.0372023); expected 358.6 (0.02)
Passed bias filter:                      501  (0.0279436); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1116.28
//
Query:       EFC38423.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.011   15.3   0.0      0.015   14.9   0.0    1.2  1  Sec23_trunk  Sec23/Sec24 trunk domain
      0.077   12.6   0.0        2.9    7.4   0.0    2.1  2  SGL          SMP-30/Gluconolactonase/LRE-like region


Domain annotation for each model (and alignments):
>> Sec23_trunk  Sec23/Sec24 trunk domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   0.0   1.7e-06     0.015      46     148 ..     101     210 ..      95     241 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.7e-06
                  EEEESSSEEEEETSTTSSSSE...EEEECHTTSCCSSTSSSSSEETTTTH....HHHHHHHHHHHHHSTT-TTC-----HHHHHHHHHHHHCHCTS-E CS
  Sec23_trunk  46 litfdsvvhffelkselrqpk...elvvsdlqdvflpladrlLvplsese....avledlLeelpemfavtagkrperalgpalkaavellkavetgg 136
                  +i +ds + +f+lks l++++    l  + ++ vf+p ++ +++  ++ +    ++  +  e++++  +++   r +r++g+  +   +l+  ++ gg
   EFC38423.1 101 VIDYDSKIFVFDLKSGLEKTEitvGLEDEMVDMVFTPEEEMIVCGSNQWHilkfNENSSCWEKIKSYSNENGPVRINRCFGVWYERKTKLIYLTDNGG 198
                  799************99555411134445577778888888888777765222123357899************************************ PP

                  EEEEEESS---S CS
  Sec23_trunk 137 kiivfvgslptv 148
                  ki++f   l  v
   EFC38423.1 199 KIFIFDRELNLV 210
                  *****9888665 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.0   0.00033       2.9      12      89 ..      97     177 ..      89     179 .. 0.81
   2 ?    3.1   0.0    0.0067        60       6      61 ..     182     237 ..     181     243 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00033
         SGL  12 gaLlwvDilgqrihrldpatgketvldtpe....svGaiaprkdgrlvvasksglall..dlasgeletladeeedekpllrfN 89 
                  +L+ +D   ++i+ +d+++g e++  t +    +v +++  ++++++v+ +++ ++l  + +s+ +e++ ++ +++   +r+N
  EFC38423.1  97 TELYVIDY-DSKIFVFDLKSGLEKTEITVGledeMVDMVFT-PEEEMIVCGSNQWHILkfNENSSCWEKIKSYSNEN-GPVRIN 177
                 67899997.899999***99999995555555579999999.***************97766777899999996554.777777 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.0067
         SGL   6 vwdeeegaLlwvDilgqrihrldpatgketvldtpesvGaiaprkdgrlvvasksg 61 
                 vw e++ +L++    g++i+ +d + +  + +++++   ++++ ++g++ v+ k++
  EFC38423.1 182 VWYERKTKLIYLTDNGGKIFIFDRELNLVKEIKVSGLYEIVINEQNGEMFVCDKDK 237
                 688888888888888****************************888******9976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.31s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1602.79
//
Query:       EFC38424.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.9e-12   45.4   0.3    8.1e-11   42.0   0.3    2.0  1  Methyltransf_16  Lysine methyltransferase
  ------ inclusion threshold ------
      0.093   12.6   0.1       0.23   11.3   0.1    1.7  1  DUF3721          Protein of unknown function


Domain annotation for each model (and alignments):
>> Methyltransf_16  Lysine methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.0   0.3     9e-15   8.1e-11      69     173 ..       3     122 ..       1     123 [. 0.83

  Alignments for each domain:
  == domain 1  score: 42.0 bits;  conditional E-value: 9e-15
  Methyltransf_16  69 peakviltDleellellkknielnkn................alkskvkvevLdWgeeleedllekeevDlilaaDcvYle.dslelLvkvLke 145
                      ++a v  tD++ l++l++kni+ln +                 l+++ k  +  Wge  +++++e++e+D+++  Dc+Y   d+  +L k L+e
       EFC38424.1   3 KGATVHFTDRQVLIPLIEKNIDLNCKiveqeqedndidekapILANQFKCFEYLWGE--PNEIVENTEYDFVIGCDCIYESkDMWMPLSKALHE 94 
                      57899******************9767777766665555444455555666667999..6699****************85268899******* PP

  Methyltransf_16 146 llkkeskvlvaykkrreaekkFfkllek 173
                       l+ ++++++a++ r++++ +F  ++++
       EFC38424.1  95 QLARSKNIILAHELRSQKDFSFWPHIQE 122
                      *********************9988875 PP

>> DUF3721  Protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1   2.6e-05      0.23      14      28 ..      73      87 ..      71      90 .. 0.93

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.6e-05
     DUF3721 14 lGCkGaHkmgdkWMP 28
                +GC  +++ +d+WMP
  EFC38424.1 73 IGCDCIYESKDMWMP 87
                8*************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       476  (0.0265492); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.30s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1002.64
//
Query:       EFC38425.1  [L=599]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.2e-85  287.1   5.9    2.6e-85  286.9   5.9    1.0  1  Cpn60_TCP1  TCP-1/cpn60 chaperonin family
  ------ inclusion threshold ------
      0.077   13.5   0.7       0.57   10.7   0.2    2.7  2  HTH_40      Helix-turn-helix domain


Domain annotation for each model (and alignments):
>> Cpn60_TCP1  TCP-1/cpn60 chaperonin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  286.9   5.9   2.9e-89   2.6e-85       5     486 ..      53     589 ..      49     594 .. 0.88

  Alignments for each domain:
  == domain 1  score: 286.9 bits;  conditional E-value: 2.9e-89
                 HHCCSSTTXXEEEEEE.TTSEEEEEXSHHHHHHCSXXXSHHHHHHHHHHHHCCCCCTTCHHHHHHHHHHHHHHHHHHHHCTXXHHHHHHHHHHHHHHHH CS
  Cpn60_TCP1   5 vkttlGPkGmdKmlvn.kggkvvvTnDGatilkeleiehPaakllveaaesqdeevGDGTttvviLageLleeaekliaagvhpttiiegyekalekal 102
                 +k+ lGPk +  ++v+ + g++++TnDGat ++ +++++P+a+l +e+++s d+++GDGTt+vv+La+++le++ kli++gvhp +i++ y    + + 
  EFC38425.1  53 LKSLLGPKALENLIVDrESGEIIITNDGATAIEYMKFNNPLAQLFIELSQSVDDQIGDGTTSVVVLASSMLEQSLKLIREGVHPMKIVKYYSIFNDIIE 151
                 7899************9*****************************************************************************99999 PP

                 HHH...HHHXEEBXSCSTT.HHHHHHHHHHCTTSSXXSTHHHHHHHHHHHHHCHCCCS...EECSCCC.EECCCCEECECTTSEEE.SEEEESS--SST CS
  Cpn60_TCP1 103 eaL...keiaveisseekdreeLlkvartslsskltskeaeelsklvvdAvklieene...keldlgr.ikvvkieggsledselv.eGlvldkgvlsp 193
                 ++L   ++ + e+++ e +++ + ++++t+l+sk++s++  +ls+++vd++++++ ++   k ++ g+  + ++  g+s ++++++ + ++++ +++++
  EFC38425.1 152 KHLteyQALKLELNN-ESSKSYITQLVKTTLNSKFSSTSIPNLSHIAVDSMYITKGERrfiKIIKSGKaENSITFRGSSTNETKIIsNEIIVNTNFIHE 249
                 99*544444334443.57999******************************998888889988888888899**************999999******* PP

                 TSSCEE..ECEEEEEESS-BS--HHCCHHHCCCC..SCCHHHHHHHHHHHHHHHHHHHHHHTTECEEEESS-B........-HHHHHHHHHCT-EEE-S CS
  Cpn60_TCP1 194 dmpkkl..enakvllldvsLeiektetkttvvls..daeeleklekaeekqleellekiiksgvnvvvcqkgi........ddlalhflakngilalrr 280
                 +m++ +  +n k++l+ ++L+ +k + +   +++  d +++++l k+ee ++++++ +++k+gv ++ +q+          +d+a+ +l+k++i ++  
  EFC38425.1 250 NMKENVnlKNQKLALVLFELDKPKAHKSRLDDINsiDNSQIDRLIKEEESYIKKIVVQLKKLGVGLICVQENLsagfhagvSDTAKFWLQKSKINCMIP 348
                 **999888***************99665544444227899**************************999986655556666****************** PP

                 --HHHHHHHHHHHT--EBSCGGGGGCGC...........-EEEEEEEECCETTCCEEEEECE....SSSSXEEEEEEESTCCCHHHHHHHHHHHHHHHH CS
  Cpn60_TCP1 281 vkkkdlerlakatGatavssledltpee...........lGtakkveeekigsekttiieev....ksgkiatillrgatdtvldeieraiedAlnvvk 364
                 ++k++++ +a a   +a+ss+++l++             + +++ v++ +ig ++++ + ++    ++  +ati+l ++t++ +de+era++dAl+vv+
  EFC38425.1 349 ISKDEMNLIADAFQLHAISSIDQLSNLVesgtteekgkfVQSIEYVKHLSIGRQSFISFGQTaeqyQNYPCATIVLSAPTQVAVDEVERALHDALRVVE 447
                 *********************9988743356666666664444555555788888888875455559999***************************** PP

                 HHHHHHEEEETTTCHHHHHHHHHH.......CCCCTSXCCHHHHHHHHHHHHTHHHHHHHHHCTS.XHHHHHHHHHH......HHHTTXTTEEEETTTT CS
  Cpn60_TCP1 365 naiedekvvpGGGatelelakklk.......eyaksvsgeeqlaieafakALevipktLaeNaGl.dpievlaklra......ahnkgekelgidvesg 449
                   ++++ +vpGGGa e++l+++++       +++++ s  e+l++  f++A+e++p +L + +    p ++l++lr+       hn+   ++gi + ++
  EFC38425.1 448 VCFKHPSLVPGGGACEMSLSAYIHcnflnstTNSNKCSPLEKLIMASFSNAIEEVPHILSQGCQNhVPSALLNELRHiytesiYHNQPSPNVGIYLSNQ 546
                 ***********************9877776667777999**********************99542568888888885544444599999******999 PP

                 C......EEECCCCTXEEEHHHHHHHHHHHHHHHHHHHCEEEE CS
  Cpn60_TCP1 450 e......iidlveagvvDplkvkrqalksAteaastiLridei 486
                 +      i+d++e++v++ l+ k + +k+A ++++ iL+i ++
  EFC38425.1 547 QeetlhpIQDMKERKVFELLHSKISQMKMALQTVQRILKIRKV 589
                 9***************************************987 PP

>> HTH_40  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.2   6.4e-05      0.57       3      57 ..     124     176 ..     122     197 .. 0.78
   2 ?   -1.8   0.0      0.49   4.4e+03      49      72 ..     349     372 ..     334     388 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 6.4e-05
      HTH_40   3 eetlelleeglsieeIAkerglkesTIegHLaelieegeeidlerlvseeeekeI 57 
                 e++l+l++eg  + +I k  ++    Ie+HL+e+   +  ++l++  s++ + ++
  EFC38425.1 124 EQSLKLIREGVHPMKIVKYYSIFNDIIEKHLTEYQALK--LELNNESSKSYITQL 176
                 89*******************************99984..555554455444444 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.49
      HTH_40  49 vseeeekeIeeaiekvgseklkpi 72 
                 +s++e + I++a++ +  +++ ++
  EFC38425.1 349 ISKDEMNLIADAFQLHAISSIDQL 372
                 578888888888887765554443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (599 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       883  (0.0492498); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.25s 00:00:00.79 Elapsed: 00:00:00.41
# Mc/sec: 4339.46
//
Query:       EFC38426.1  [L=481]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1010  (0.0563333); expected 358.6 (0.02)
Passed bias filter:                      501  (0.0279436); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 2991.01
//
Query:       EFC38427.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.9e-07   30.0  12.1    5.2e-07   29.6  12.1    1.2  1  Prefoldin_2  Prefoldin subunit
  ------ inclusion threshold ------
       0.32   10.8   2.0       0.46   10.3   0.1    1.9  2  RVT_3        Reverse transcriptase-like
        1.2    9.5   7.7       0.67   10.3   0.8    2.1  1  Ly49         Ly49-like protein, N-terminal region


Domain annotation for each model (and alignments):
>> Prefoldin_2  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6  12.1   8.7e-11   5.2e-07       3      93 ..      11     102 ..       6     114 .. 0.85

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 8.7e-11
                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS-TT--EE.EEETTEEEEE-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Prefoldin_2   3 linkfqqlqqqlqqlaqqikqletqlkelelvleelelldedtkvy.klvGdvlvkqdkeevkeeLeerketlekeiktlekqleklekele 93 
                  ++ + q++ q +   ++qi+ql+t+ k + l++  +++l++d+kv+ + +G+ ++++d +e++e+  e+k+ ++ e +++++q+e+ +k l+
   EFC38427.1  11 EQSQIQEIIQNILIDQEQINQLRTKQKQATLAESSIDKLKDDEKVWsCGIGGFFIQVDAKEMREMIREEKKVCKSEQSQISNQIEESQKLLT 102
                  34445555555555589*************************9998579*************************************999776 PP

>> RVT_3  Reverse transcriptase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.4      0.13   7.9e+02      73      96 ..       6      28 ..       3      45 .. 0.68
   2 ?   10.3   0.1   7.6e-05      0.46      54     104 ..      54     104 ..      53     111 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.13
       RVT_3 73 vqllngrekvksselanlldeirk 96
                 q++ ++++  ++ ++n+l +  +
  EFC38427.1  6 EQQIEEQSQ-IQEIIQNILIDQEQ 28
                577777777.77777777665444 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 7.6e-05
       RVT_3  54 lalklgirrlvvegDsktvvqllngrekvksselanlldeirkllksfesv 104
                 +++++gi    +++D k+  + +++++kv++se +++ ++i + +k ++s+
  EFC38427.1  54 KVWSCGIGGFFIQVDAKEMREMIREEKKVCKSEQSQISNQIEESQKLLTSI 104
                 6899************************98888888888877776665554 PP

>> Ly49  Ly49-like protein, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.8   0.00011      0.67      70     111 ..      16      58 ..       3      65 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00011
                 XX..HH.HHHHHHHHHHHHHHHHHTTTSXSXXXXXX-SCCEEE CS
        Ly49  70 csilkd.lleslkreqkrlysktktvlkslqntGklvekhwfC 111
                  +i+++ l+++ + +q r  +k+ t+ +s+ ++ k  ek w+C
  EFC38427.1  16 QEIIQNiLIDQEQINQLRTKQKQATLAESSIDKLKDDEKVWSC 58 
                 333344488999999***************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2536  (0.141447); expected 358.6 (0.02)
Passed bias filter:                      625  (0.0348597); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 709.88
//
Query:       EFC38428.1  [L=302]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.2e-51  173.9   1.7    5.6e-51  173.4   1.7    1.2  1  Translin       Translin family
  ------ inclusion threshold ------
      0.039   14.6   3.8      0.067   13.8   3.8    1.3  1  FXMRP1_C_core  Fragile X-related 1 protein core C terminal
      0.059   12.4   0.7       0.12   11.4   0.7    1.5  1  Ric8           Guanine nucleotide exchange factor synembryn
      0.068   13.6   1.1       0.14   12.6   1.1    1.5  1  PRP1_N         PRP1 splicing factor, N-terminal
          4    8.4   5.7         25    5.8   0.3    3.2  3  SCVP           Secreted clade V proteins


Domain annotation for each model (and alignments):
>> Translin  Translin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  173.4   1.7   1.6e-54   5.6e-51       2     204 ..      96     291 ..      95     292 .. 0.94

  Alignments for each domain:
  == domain 1  score: 173.4 bits;  conditional E-value: 1.6e-54
                 HHHHHHHHHHHHHHHHHHHHHHHHTTGSSTTTHHHHHHH.HHHHHHHHHHHTTSS..............GHHHHGGGTH.HHHHHHHHHHHHHHHHHSS CS
    Translin   2 rreriikasrditaaskkiifllhrvrsekteaqdkkakikkeakeklkeiakll.asvaeelqgs...nayrYqrqisgglqeliealsfahYletqt 96 
                 r+eri+ka rd+t+++k+iif lhr +     +q +k++i keakek+++i + + + v++e++++    +++Y+r++s glqeliea+sf++Y+++++
  EFC38428.1  96 RKERIYKATRDVTIEAKQIIFNLHRYD----PKQGNKEEILKEAKEKIDSIVNEHlSIVKKEIDEKfseYFWKYARSYSFGLQELIEAISFYYYIKDGS 190
                 99***********************99....346799999**********99888689999999888889***************************** PP

                 ---HHHHHHHTT.---SSSSSS---HHHHHHHHHHHHHHHHHHHHHHHCTT--S.HHHHHHHHHHHHHHHHHTS----HH........HHHHHTTHHHH CS
    Translin  97 LitleevqkilealkeneedafhltpedYllGlfdLtgELmRfainsvalgdkeekplqilkflrelragfellnlknds.....akdlrkKldvlkqs 190
                 L+t+e+++k  +         f+++  dYllG++dLtgELmRfa+n+++ +     p ++ +f++el+++f+ l ++ ++     +kdl++K++ +++s
  EFC38428.1 191 LVTCENIEKDTN---------FPVSRLDYLLGISDLTGELMRFATNHFTVET---IPPSVKDFMSELFSHFQNLLVTCKGlspyeEKDLKNKIEIMETS 277
                 ********9987.........9***************************998...589******************99889999888************ PP

                 HHHHHHHHHHHHHH CS
    Translin 191 vkKvEdvvYdlsvR 204
                 ++KvE+++Y+++++
  EFC38428.1 278 LSKVEKLCYNITLQ 291
                 ***********986 PP

>> FXMRP1_C_core  Fragile X-related 1 protein core C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   3.8   1.9e-05     0.067      44     122 ..      28     105 ..      10     117 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.9e-05
  FXMRP1_C_core  44 stDeesgessssslggsr.sysgRGrGr.RGagatsgkygtnseasnaseteseakdel.sdwslageeeegekesevrsrr 122
                    +tD es +s  +s+gg r +y++RG G  RG+g + g  g++s++ ++ ++ ++a ++l +d s + ++++  ke+ ++ +r
     EFC38428.1  28 MTD-ESPRS-TTSEGGYReNYNNRGGGGyRGRGRGGG--GYRSNQPKKPRQYKHAVEKLfDDYSNSLDDSNNRKERIYKATR 105
                    455.33333.445555551568888888899888866..5555555555555544444416677777777766777766666 PP

>> Ric8  Guanine nucleotide exchange factor synembryn
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.7   3.4e-05      0.12     128     228 ..      75     256 ..      65     299 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3.4e-05
        Ric8 128 laealeqilkrkakevsssdeaasslskeesealselLKllFnltlhypksvldeeeaeelsek................................... 191
                   +a+e+ ++  +++++ s+++++++ k  +++++e+  ++Fnl  + pk+ ++ee  +e +ek                                   
  EFC38428.1  75 YKHAVEKLFDDYSNSLDDSNNRKERIYKATRDVTIEAKQIIFNLHRYDPKQGNKEEILKEAKEKidsivnehlsivkkeidekfseyfwkyarsysfgl 173
                 4578899999999999999******************************99988754433344455556666666666666667777777777777777 PP

        Ric8 192 ...........................................larllppllrlllllpipspd...pLkpplthlinaLlnl 228
                                                            l++ l+   +  +++++  p+    ++++++h+ n+L++ 
  EFC38428.1 174 qelieaisfyyyikdgslvtceniekdtnfpvsrldyllgisdLTGELMRFATNHFTVETIPPSvkdFMSELFSHFQNLLVTC 256
                 77777777777777777777777777777777777777777775555555544333333333333555566777777777664 PP

>> PRP1_N  PRP1 splicing factor, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   1.1   3.8e-05      0.14       8     104 ..      56     152 ..      52     170 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.8e-05
                 HHHHT------............................---------------------------------------HHHHHHHHHHHHHHTT--- CS
      PRP1_N   8 GlGRGAtGfttrsdigpareaeaseeekkkkkeeeeeeeedeedlqdeendefegeseglfakaeydedDeeAdriyeeiderlderrkkrreakek 104
                 G GRG  G+ +++  +p + ++a e+  ++ +++ +++++++e++ +++ d + + ++ +f+ ++yd    + ++i +e  e++d+  +++ +  +k
  EFC38428.1  56 GRGRGGGGYRSNQPKKPRQYKHAVEKLFDDYSNSLDDSNNRKERIYKATRDVTIEAKQIIFNLHRYDPKQGNKEEILKEAKEKIDSIVNEHLSIVKK 152
                 99**********99999555555555566666677888999999999999999999999********************999999876666555555 PP

>> SCVP  Secreted clade V proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.3     0.007        25      13      43 ..      69     100 ..      64     110 .. 0.72
   2 ?    3.8   0.3     0.029     1e+02       5      60 ..     115     171 ..     111     199 .. 0.71
   3 ?   -1.3   0.0       1.2   4.3e+03      80      91 ..     247     258 ..     229     290 .. 0.69

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.007
        SCVP  13 psknksyldefekklkeyakslgisydk.dls 43 
                 p+k  +y++ +ek++++y++sl+ s ++ +++
  EFC38428.1  69 PKKPRQYKHAVEKLFDDYSNSLDDSNNRkERI 100
                 4444558999*************777664544 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.029
        SCVP   5 lvtnepydpsk..nksyldefekklkeyakslgisydkdlsdekvtnvnGkfavtytl 60 
                 ++  + ydp++  +++ l+e+++k++  ++++  s  k+++dek  ++  k+a +y +
  EFC38428.1 115 IFNLHRYDPKQgnKEEILKEAKEKIDSIVNEHL-SIVKKEIDEKFSEYFWKYARSYSF 171
                 666788888888455558888888888887666.334467777666666666666665 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 1.2
        SCVP  80 sfitnatvkCgs 91 
                 s+++n  v+C++
  EFC38428.1 247 SHFQNLLVTCKG 258
                 455555566654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1250  (0.0697194); expected 358.6 (0.02)
Passed bias filter:                      566  (0.031569); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 1973.21
//
Query:       EFC38429.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-10   41.4   0.0    1.6e-10   40.9   0.0    1.3  1  PrmA             Ribosomal protein L11 methyltransferase (Prm
    4.5e-09   36.1   0.2    1.3e-05   24.8   0.2    2.2  2  MTS              Methyltransferase small domain
    1.1e-08   35.0   0.1    1.8e-06   27.7   0.1    2.2  1  Cons_hypoth95    Conserved hypothetical protein 95
    3.6e-06   27.6   0.2      1e-05   26.1   0.2    1.9  1  Methyltransf_25  Methyltransferase domain
    5.1e-06   26.3   1.3    9.7e-06   25.5   1.1    1.6  1  Methyltransf_31  Methyltransferase domain
    0.00012   21.9   0.0    0.00024   21.0   0.0    1.5  1  Methyltransf_23  Methyltransferase domain
    0.00063   19.5   0.8     0.0011   18.7   0.2    1.7  2  Methyltransf_16  Lysine methyltransferase
     0.0017   18.1   0.2        0.1   12.3   0.2    2.3  1  UPF0020          Putative RNA methylase family UPF0020
      0.003   17.2   0.7     0.0054   16.3   0.7    1.4  1  MetW             Methionine biosynthesis protein MetW
  ------ inclusion threshold ------
      0.014   16.1   0.0      0.029   15.0   0.0    1.7  1  Methyltransf_11  Methyltransferase domain
      0.017   15.3   0.0      0.024   14.8   0.0    1.3  1  FtsJ             FtsJ-like methyltransferase
      0.028   15.2   0.3       0.13   13.1   0.3    2.1  2  Methyltransf_12  Methyltransferase domain
      0.034   14.1   0.1      0.071   13.1   0.1    1.7  1  Methyltransf_32  Methyltransferase domain
      0.069   13.5   0.3       0.13   12.6   0.3    1.4  1  zf-C4H2          Zinc finger-containing protein
      0.092   12.5   0.0       0.12   12.1   0.0    1.3  1  PCMT             Protein-L-isoaspartate(D-aspartate) O-methyl
        0.1   12.5   0.0        0.2   11.5   0.0    1.6  1  OAM_alpha        D-ornithine 4,5-aminomutase alpha-subunit


Domain annotation for each model (and alignments):
>> PrmA  Ribosomal protein L11 methyltransferase (PrmA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.9   0.0   1.5e-13   1.6e-10     161     206 ..      49      94 ..      39     138 .. 0.85

  Alignments for each domain:
  == domain 1  score: 40.9 bits;  conditional E-value: 1.5e-13
        PrmA 161 egeevlDvGtGSGiLaiaaakLgakkvvavDiDevAvkvakeNael 206
                 eg+evlD+G G+G+L ++a +L+ak+v++vDiDe A+++ +eN++ 
  EFC38429.1  49 EGKEVLDLGIGTGMLGLGACLLEAKHVTGVDIDEDALNICRENVKS 94 
                 6899***************************************985 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   0.2   1.1e-08   1.3e-05      31      77 ..      49      94 ..      41     127 .. 0.85
   2 !    9.0   0.0   0.00085      0.96      90     132 ..     136     184 ..     124     207 .. 0.67

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 1.1e-08
                TCSEEEEET-TTSHHHHHHHHHTTC.EEEEEESBHHHHHHHHHHHHH CS
         MTS 31 lsgkvlDlGcGaGvlgaalakespeaevtlvdvdarAlesakenlea 77
                + ++vlDlG G+G+lg+ +   + + +vt vd+d  Al++++en+++
  EFC38429.1 49 EGKEVLDLGIGTGMLGLGACLLEAK-HVTGVDIDEDALNICRENVKS 94
                6789*************99887777.8*****************986 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00085
                 TTTSTT..S-EEEEEE---STTTCH....CHHHHHHHHHHHHHHHEEEE CS
         MTS  90 leevee..kkfdlivsNPPfhagka....telavaeeliaeAkeaLkeg 132
                 ++++e+  + fd+++ NPPf +  +    + l+va el ++A   L+++
  EFC38429.1 136 YKKIEDgyRLFDTVLLNPPFGTRIKgadmMFLKVASELTRNAVYSLHKT 184
                 55555411469*********87665111133466777777777776665 PP

>> Cons_hypoth95  Conserved hypothetical protein 95
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.1   1.6e-09   1.8e-06      39     155 ..      47     186 ..      36     203 .. 0.76

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 1.6e-09
                    CHCC-EEEETT-TTSHHHHHHHHTT-SEEEEEES-HHHHHHHHHHHCCCT--T....................TTEEEEES-HHHHCTS--SS-E. CS
  Cons_hypoth95  39 eiegarvLDlfaGsGalglEAlSRgakkavlvekdkeavkilkenleelklee....................etaelkedaleallklakkkee. 113
                    +ieg++vLDl  G+G lgl A   +ak+++ v+ d+ a++i++en++++  +                     +++ ++++++++l+ + kk e  
     EFC38429.1  47 DIEGKEVLDLGIGTGMLGLGACLLEAKHVTGVDIDEDALNICRENVKSIIDDVdeemaqhftyrldliqsdvlQFERMIKNRAQKLKDKYKKIEDg 142
                    499*******************************************99753224456677788888888888777777777777777665554323 PP

                    ...EEEEEE--SSSTTCH.HHHHHHHHHTT-EEEEEEEEEEEECC CS
  Cons_hypoth95 114 ...fdivflDPPyakellieevlelleekkllkenalvvveteke 155
                       fd v l+PP+ +     + +  l+  + l++na+  + + ++
     EFC38429.1 143 yrlFDTVLLNPPFGTRIK-GADMMFLKVASELTRNAVYSLHKTST 186
                    334999999999999865.67777777777788877776665554 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   0.2   9.3e-09     1e-05       1      44 [.      53      97 ..      53     132 .. 0.76

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 9.3e-09
                     EEEET-TTSHHHHHHHCTSTSSEEEEEESSHHHHHHHHHHHHH..T CS
  Methyltransf_25  1 vLdlGcGtGrltlalakrlgkakvtgvDiseemleaareraee..e 44
                     vLdlG GtG l l +    ++++vtgvDi+e++l+++re++++  +
       EFC38429.1 53 VLDLGIGTGMLGLGACLL-EAKHVTGVDIDEDALNICRENVKSiiD 97
                     9********998877755.67*******************976552 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.5   1.1   8.6e-09   9.7e-06       4      81 ..      50     117 ..      47     174 .. 0.76

  Alignments for each domain:
  == domain 1  score: 25.5 bits;  conditional E-value: 8.6e-09
  Methyltransf_31   4 glrvlDlGCGtGeltfelaeelgpkaevvGiDiseeaielArenaqklgldnveFeqgdiee.leklledekfDlilsn 81 
                      g++vlDlG GtG l++ +   l + ++v+G+Di+e+a++ +re        nv+  + d+ e + ++++  + Dli s+
       EFC38429.1  50 GKEVLDLGIGTGMLGLGAC--LLEAKHVTGVDIDEDALNICRE--------NVKSIIDDVDEeMAQHFT-YRLDLIQSD 117
                      789****************..67899*****************........566666666665554444.456665553 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   2.1e-07   0.00024      20     161 ..      47     200 ..      32     205 .. 0.64

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 2.1e-07
  Methyltransf_23  20 lraggrvLdiGcGtGil.levlrengfsvtgvDlspeaveiaekakkaqkdqfdeqeaaepqgkfdlIvlrevlehvpdppellrqiatllk.. 110
                      + +g++vLd+G GtG l l  +  + ++vtgvD+++ a +i ++  k++ d +de+ a+    + dlI +++vl   +      +++++  k  
       EFC38429.1  47 DIEGKEVLDLGIGTGMLgLGACLLEAKHVTGVDIDEDALNICRENVKSIIDDVDEEMAQHFTYRLDLI-QSDVLQFERMIKNRAQKLKDKYKki 139
                      67899**********542444466778****************8888888888888888877777776.4455544444444444444444433 PP

  Methyltransf_23 111 pgGylllseplasl.......kedrllldwlylvpag...rhisffsarslkelleeaGle 161
                      ++Gy l+ ++l +         +d+++l+++ + +++    + +  +++ + + + ++G+e
       EFC38429.1 140 EDGYRLFDTVLLNPpfgtrikGADMMFLKVASELTRNavySLHKTSTRDYVTQKAAKWGFE 200
                      4566666664433345665544666666666666666333333444555555556666665 PP

>> Methyltransf_16  Lysine methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.2   9.9e-07    0.0011      39      91 ..      42      94 ..      21     134 .. 0.82
   2 ?   -2.6   0.0       3.5   3.9e+03      93     122 ..     183     210 ..     167     211 .. 0.65

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 9.9e-07
  Methyltransf_16 39 elganelsklsvlELGsGtGlvGlavaellpeakviltDlee.llellkkniel 91
                     ++  ++ ++++vl+LG GtG+ Gl + +l +  +v+  D++e +l++ ++n++ 
       EFC38429.1 42 QFSFDDIEGKEVLDLGIGTGMLGLGACLL-EAKHVTGVDIDEdALNICRENVKS 94
                     3778899*****************99988.8889999999887999*9**9986 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 3.5
  Methyltransf_16  93 knalkskvkvevLdWgeeleedllekeevD 122
                      k  +++ v+ ++ +Wg e+  +++++ ++D
       EFC38429.1 183 KTSTRDYVTQKAAKWGFEV--KVVAELNYD 210
                      3467788888888998877..555555666 PP

>> UPF0020  Putative RNA methylase family UPF0020
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.2   9.2e-05       0.1     114     168 ..     138     193 ..      59     198 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 9.2e-05
                 G--STTS---EEEE----------HHHH.HHHHHHHHHHHHHH-TT..-EEEEEES CS
     UPF0020 114 kLrlkegevdvivtnpPYGerlgskkal.ekLYseflrelkrvlrgggrlvlltse 168
                 k++     +d+++ npP+G r++ + ++  k  se+ r +   l++ +   ++t++
  EFC38429.1 138 KIEDGYRLFDTVLLNPPFGTRIKGADMMfLKVASELTRNAVYSLHKTSTRDYVTQK 193
                 333333469*************9999888999999999999999988777777765 PP

>> MetW  Methionine biosynthesis protein MetW
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.7   4.8e-06    0.0054      14      89 ..      50     123 ..      47     142 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.8e-06
        MetW  14 gsrvldlGcGdGel..lellkeekqvdgrGleldeegvaecvakGlsviqgdldkdlenfedksfdyvvlsqtlqatr 89 
                 g +vldlG G G l     l e k+v+g  +++de++++ c    ++ i +d+d++++++   ++d+ + s  lq  r
  EFC38429.1  50 GKEVLDLGIGTGMLglGACLLEAKHVTG--VDIDEDALNICR-ENVKSIIDDVDEEMAQHFTYRLDL-IQSDVLQFER 123
                 678*********9742467889999986..556666666665.45777789********99999997.5677777544 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.0   2.6e-05     0.029       1      41 [.      54      95 ..      54     137 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 2.6e-05
                     EEET-TTSHHHHHHH.HTTSEEEEEES-HHHHHHHHHHCCHH CS
  Methyltransf_11  1 LdvGcGtGrlaeala.krgarvvgvDlskemlklakekasee 41
                     Ld+G GtG l        +++v+gvD+++ +l++++e+++  
       EFC38429.1 54 LDLGIGTGMLGLGAClLEAKHVTGVDIDEDALNICRENVKSI 95
                     79999988765555524469****************998764 PP

>> FtsJ  FtsJ-like methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0   2.1e-05     0.024      15      97 ..      42     120 ..      34     183 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.1e-05
                 HHT-S-..TT-EEEECT-TTSHHHHHHCCT.T.-SEEEEEESSSSHHH...TTEEEECS-CCCSSHHHHHCHCHHHSSEEEEEE--S- CS
        FtsJ  15 kfklfk..pgktvvDlgaaPGgwsqvllqrlgakgkvvavDlqpmapl...pgvttiqgditdpetiekikealserkvdlvvsDgap 97 
                 +f+ f+  +gk v+Dlg ++G     ++   +a ++v +vD+ + a+    ++v++i  d+ ++ ++          + dl+ sD+  
  EFC38429.1  42 QFS-FDdiEGKEVLDLGIGTGMLGLGACLL-EA-KHVTGVDIDEDALNicrENVKSIIDDVDEEMAQHFTY------RLDLIQSDVLQ 120
                 666.655799***********765555544.44.78******999544456**********7776666444......47888888764 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.3   0.00011      0.13       1      46 [.      54      98 ..      54     152 .. 0.86
   2 ?   -0.6   0.0       2.1   2.3e+03      30      59 ..     122     151 ..     120     191 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 0.00011
  Methyltransf_12  1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrenn 46
                     L++G GtG l    +   + +++tgvDi+++a++  +e  ++++++
       EFC38429.1 54 LDLGIGTGMLGLGACLL-EAKHVTGVDIDEDALNICRENVKSIIDD 98
                     78899999887665555.67*************9999999988865 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 2.1
  Methyltransf_12  30 psaiedakeklakrennnnnnvelealdll 59 
                      +++i+++++kl+++ ++  + ++l+++ ll
       EFC38429.1 122 ERMIKNRAQKLKDKYKKIEDGYRLFDTVLL 151
                      567878888888777766666666655554 PP

>> Methyltransf_32  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   6.3e-05     0.071      25      86 ..      49     107 ..      32     182 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 6.3e-05
  Methyltransf_32  25 galtvvDvGaGkgYLsfvlalkekeyklkvvgidakeelvekaekraeklgkkfnkrlsfae 86 
                      + ++v+D+G G g L+    l       +v+g+d+ e+  + +++  + +  ++++++ ++ 
       EFC38429.1  49 EGKEVLDLGIGTGMLGLGACL---LEAKHVTGVDIDEDALNICRENVKSIIDDVDEEMAQHF 107
                      5689*************9999...7789*************999999999999988887654 PP

>> zf-C4H2  Zinc finger-containing protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.3   0.00011      0.13      31      86 ..      87     143 ..      74     151 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00011
     zf-C4H2  31 kcleeykkelelLeqEkmaHve.eLrlIhaDinalEsvikeaeeekekslekakkly 86 
                  c e++k+ ++ +++E  +H    L lI++D+ + E++ik+  ++ + + +k++  y
  EFC38429.1  87 ICRENVKSIIDDVDEEMAQHFTyRLDLIQSDVLQFERMIKNRAQKLKDKYKKIEDGY 143
                 4667899999**********8648*****************9999999999888765 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   0.00011      0.12      47     119 ..      20      93 ..       1     117 [. 0.68

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00011
                 -EEEETTEEE--HHHHHHHHHHTT..--..TT-EEEEES-TTSHHH..HHHHHHHCTTCEEEEEESBHHHHHHHHHHHH CS
        PCMT  47 plsigynatiSaphmvalalelle..lk..kgarvLevGsGsGylt..avlarlvgekgrvvsierikelveeakrnlk 119
                 p +i  +++i  ph+ + +l   +  ++  +g++vL++G G+G l   a+l +    k  v +++  ++  +  ++n+k
  EFC38429.1  20 P-KIKLEQYITTPHLASHTLYTAQfsFDdiEGKEVLDLGIGTGMLGlgACLLEA---KH-VTGVDIDEDALNICRENVK 93 
                 3.48999*******9888776666444433799**********97522555433...33.5566666666666666665 PP

>> OAM_alpha  D-ornithine 4,5-aminomutase alpha-subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00018       0.2      22     107 ..       7      92 ..       1     103 [. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00018
                 HHHHHHHHHHHHHHHHHHHHHEE-HHHHHHHHH..HTT--HHHHHHHHHHHHHTTGGGG-HHHHHHHHHHHTT--HHHHHHHHHTTTS CS
   OAM_alpha  22 eerfWelaekivdPlielarkhtspsiersvLL..rmGlssleakaivekvlekgllgkGaGhvvyrlakeknidireagealaegkl 107
                 e+   + +++  +P i+l +  t+p +    L   +  ++ +e k++++  + +g+lg Ga  ++++  + +++di e + +++++++
  EFC38429.1   7 ESFLQDHIQNFQKPKIKLEQYITTPHLASHTLYtaQFSFDDIEGKEVLDLGIGTGMLGLGA--CLLEAKHVTGVDIDEDALNICRENV 92 
                 5555556778889**************9999973357899*****************8877..7888888999999999999888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1014  (0.0565564); expected 358.6 (0.02)
Passed bias filter:                      539  (0.030063); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 1488.07
//
Query:       EFC38430.1  [L=610]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-44  152.8   0.3    1.7e-44  152.2   0.3    1.3  1  Pkinase         Protein kinase domain
    4.5e-26   91.7   0.1    6.4e-26   91.2   0.1    1.1  1  Pkinase_Tyr     Protein tyrosine kinase
      0.008   15.6   0.0      0.012   14.9   0.0    1.2  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.018   13.9   0.0      0.029   13.2   0.0    1.2  1  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  152.2   0.3   3.7e-48   1.7e-44       1     259 [.     347     602 ..     347     605 .. 0.83

  Alignments for each domain:
  == domain 1  score: 152.2 bits;  conditional E-value: 3.7e-48
                 EEEEEEEEEESSEEEEEEEET.TTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHH.HHSS- CS
     Pkinase   1 yekleklGeGsfGkVykavek.etgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlle.rkgsl 95 
                 y+ +ek+G+GsfG ++ + ++ ++++ vA+K i+ e+++++   k+++E++  ++++h++iv++ye+f +   + ++lv+ y +g+ l++ +    +++
  EFC38430.1 347 YKPIEKIGNGSFGICFLCQDTkRNNQLVAIKGINLESNDQE---KIISELSKSATIQHQRIVEVYEFFVSkqMNAFCLVMKYYSGD-LERCVLkYGKIM 441
                 67789*************985157889*********98874...59**********************984456789*******77.666555267779 PP

                 -HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTE......EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHH CS
     Pkinase  96 seeeakkiakqilegleylH.skgiiHrDlKpeNiLidekge......lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvil 187
                 +e  + +++kq+ eg++ylH  k+++HrD+Kp Ni++++ +e      + i+D+G +kel  ++  +++ gt  Y+APEv    +y+ ++D++slGv l
  EFC38430.1 442 PEIVVIQLLKQLGEGFDYLHrVKQVVHRDVKPRNIFVNNFDElnnqisVVIGDLGESKELFVQE--NTMRGTVLYMAPEVF-IGKYGFPADIFSLGVSL 537
                 999*****************6678**************7333455678************9988..9*************9.678************** PP

                 HHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS.....-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 188 yelltgkppfsgekgkekvekeldqlekilkilgetkeklpeasei.....seeakdllkkllkkdpkkRltaeell 259
                 y ++ g   ++   g++  ++  ++             +++ ++e+     s+++ d++ ++++++p++R+tae+++
  EFC38430.1 538 YHVMVGMKNLNVPIGQQMLASSEQE------------ISSRMREEMlklgySDKLVDFVISMIRVNPNDRPTAEQVK 602
                 *******999966665522222222............22233333334466***********************986 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.2   0.1   1.4e-29   6.4e-26       4     256 ..     350     602 ..     347     604 .. 0.83

  Alignments for each domain:
  == domain 1  score: 91.2 bits;  conditional E-value: 1.4e-29
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHTCTTT CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct..keepllivteyvkgGdLlkfLrkkekek 99 
                   +k+G+G+fG  + ++ +   +++++ Va+K ++ e+++  +e++++e++   +++h++iv+++ + +  + +  ++v++y  +GdL+  + k   + 
   EFC38430.1 350 IEKIGNGSFGICFLCQDT---KRNNQLVAIKGINLESND--QEKIISELSKSATIQHQRIVEVYEFFVskQMNAFCLVMKYY-SGDLERCVLKY-GKI 440
                  589**********99988...888999******655555..59**********************9996555569*****98.69*****9998.999 PP

                  SBHHHHHHHHHHHHHHHHHHHH.TTEEEST-SGGGEEEEE......TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHH CS
  Pkinase_Tyr 100 ltlkdllsfalqvAkGmeyLes.kklvHrdlaarNvLlse......nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWs 190
                  +    ++++  q+ +G +yL++ k++vHrd+  rN+++++      +  v i+D G ++++      v++++ +  v +mapE++  +k+   +D++s
   EFC38430.1 441 MPEIVVIQLLKQLGEGFDYLHRvKQVVHRDVKPRNIFVNNfdelnnQISVVIGDLGESKEL-----FVQENTMRGTVLYMAPEVFI-GKYGFPADIFS 532
                  99999****************94569*************999997666899*****99999.....888999999********875.789******** PP

                  HHHHHHHHHTTSSGT....TTTSHHHHHHHHHHTTEES-B.BTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 191 fGvllwEiftlgesp....ypglkneevleklkegkrlek.pekcpeelyelmkkcweedpeeRptfselv 256
                   Gv l+ ++  g +     + + + ++  + ++++ r e+     +++l +++ +  + +p++Rpt +++ 
   EFC38430.1 533 LGVSLYHVMV-GMKNlnvpIGQQMLASSEQEISSRMREEMlKLGYSDKLVDFVISMIRVNPNDRPTAEQVK 602
                  ********98.555411114444444445555444443331446899*******************99875 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   2.7e-06     0.012     104     162 ..     429     491 ..     391     506 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.7e-06
         Kdo 104 dLedllakwae.laeelkrallkavgrliaklhra.gvnHadlyaknillqqee..eeeaeiw 162
                 dLe ++ k+ + ++e +  +llk++g  +  lhr+ +v H+d+ ++ni++++ +  ++++ ++
  EFC38430.1 429 DLERCVLKYGKiMPEIVVIQLLKQLGEGFDYLHRVkQVVHRDVKPRNIFVNNFDelNNQISVV 491
                 8999999988888999999***************74789***********9988334444444 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   6.4e-06     0.029     317     386 ..     455     520 ..     439     530 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 6.4e-06
  Pkinase_fungal 317 kghrsLflkagiLHrDiSenNilitdskke.gerkglLiDLDlakelsddssesgarertGTleFmaievl 386
                     +g+  L++ ++++HrD+   Ni +++ ++  ++ + ++ DL   kel       ++++  GT+ +ma ev 
      EFC38430.1 455 EGFDYLHRVKQVVHRDVKPRNIFVNNFDELnNQISVVIGDLGESKELFV-----QENTMRGTVLYMAPEVF 520
                     68889********************98665256666677********96.....334578******98886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (610 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       642  (0.0358079); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.27s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 3520.68
//
Query:       EFC38431.1  [L=106]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (106 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       610  (0.0340231); expected 358.6 (0.02)
Passed bias filter:                      245  (0.013665); expected 358.6 (0.02)
Passed Vit filter:                         8  (0.000446204); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.32s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 634.85
//
Query:       EFC38432.1  [L=343]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (343 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1179  (0.0657594); expected 358.6 (0.02)
Passed bias filter:                      199  (0.0110993); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 1992.03
//
Query:       EFC38433.1  [L=929]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-10   40.4  12.8    1.8e-10   40.4  12.8    2.3  2  Ion_trans    Ion transport protein
    4.8e-10   38.7  13.3    4.8e-10   38.7  13.3    1.7  2  PKD_channel  Polycystin cation channel
  ------ inclusion threshold ------
       0.02   14.6   0.9       0.05   13.3   0.2    2.1  2  DUF3989      Protein of unknown function (DUF3989)
        1.4    8.9  10.6          3    7.8   0.3    3.4  3  Reticulon    Reticulon


Domain annotation for each model (and alignments):
>> Ion_trans  Ion transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.3     0.011        51      63     110 ..     371     407 ..     341     429 .. 0.60
   2 !   40.4  12.8   4.1e-14   1.8e-10      62     242 ..     565     741 ..     546     743 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.011
                 HHHCHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.GGGGGGHHH CS
   Ion_trans  63 krYlrdpwnilDflvvlpsllslvlseesllllsvlrlf.rvlrllkli 110
                  + l++p  ++ +l+++++l+sl+             +f  ++r +++i
  EFC38433.1 371 ANVLSSPLTWISILIIVFALFSLF------------LIFrAIYRSFRFI 407
                 445555555555555555555443............3332233333333 PP

  == domain 2  score: 40.4 bits;  conditional E-value: 4.1e-14
                 HHHHCHSHHHHHHHHHHHHHHHHH....HHHH.........HHHHHHHHHHHHGGGGGGHHHCHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans  62 kkrYlrdpwnilDflvvlpsllsl....vlse.........esllllsvlrlfrvlrllklisrleglrtlvtalirsvkdllnvlllllvvlfifali 147
                 k++++ +pw +l +++ l+ ++s     +  +          +++ll +  +f ++ +++++s+++++ +l+++l + +++++++++ ++ +l+ +al+
  EFC38433.1 565 KLKFF-NPWHVLGIISNLFCIVSScmvfT--NvtyqyfsldATNILLGLSAIFMWANIVQYLSHSPKFYVLIKSLRKGLPNIGRFIIGAAPLLIGYALC 660
                 55555.45888888888888886644331..1344556666566777777777789******************************************* PP

                 HHHHHTTSCCCCCCSCCSTSSSTTTSSSSSSHHHHHHHHHHHHTTSSHHHHHHHHHHHS...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Ion_trans 148 gvqlfkgklreknecaktwenpnngntnFdnfftallwlfrlmttegwgdilyatldek...skvaliyfvifiilgsflllNlliaviadnfqelte 242
                 g+ lf g+                 + +F+ f ++l++lf  + ++ + d ++   +++     ++ iy+v+f++l+++ ++N++i ++ d++ +++e
  EFC38433.1 661 GMVLF-GS----------------YTESFQGFQNSLITLFSAANGDALIDTFNSLFGQNsviAYFSRIYLVTFVCLFTYSVINIFILIMEDAYFSVKE 741
                 *****.22................2257*******************************888888889*************************99887 PP

>> PKD_channel  Polycystin cation channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.5   0.4       1.4   6.1e+03     344     355 ..     382     393 ..     369     412 .. 0.49
   2 !   38.7  13.3   1.1e-13   4.8e-10     284     425 ..     591     738 ..     577     739 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.5 bits;  conditional E-value: 1.4
                  HHHHHHHHHHHH CS
  PKD_channel 344 vilflayaqlgv 355
                  +il++++a + +
   EFC38433.1 382 SILIIVFALFSL 393
                  333333333222 PP

  == domain 2  score: 38.7 bits;  conditional E-value: 1.1e-13
                  ----HHHHHHHHHHHHHHHHHHHHHHHGGGGG------------------------HHHHHHHHHHHHHHHHHHSSSS-STTSSHHHHHHHHHHHHTT CS
  PKD_channel 284 fldFrevaqldqllriilavlvflttlkllkvlrfnktlslltktlaralkdvlgfalvivilflayaqlgvllfGtqasnfsnlvksiltlfrlilg 381
                  f++     ++  +++i+l++  ++++  ++++l+ ++++++l k l + l+++  f +  + l++ ya  g++lfG++++ f+ +++s++tlf+   g
   EFC38433.1 591 FTNVTYQYFSLDATNILLGLSAIFMWANIVQYLSHSPKFYVLIKSLRKGLPNIGRFIIGAAPLLIGYALCGMVLFGSYTESFQGFQNSLITLFSAANG 688
                  555555556667899********************************************************************************999 PP

                  --...-HHHHHHH-TT...HHHHHHHHHHHHHHHHHHHHHHHHHHT-XXX CS
  PKD_channel 382 df...qytelesgnrv...LGpllllalvflvifillnlflaiindsyee 425
                  d     ++ l+  n v   ++ ++l+++v l  + ++n+f+ i+ d+y +
   EFC38433.1 689 DAlidTFNSLFGQNSViayFSRIYLVTFVCLFTYSVINIFILIMEDAYFS 738
                  97444688898888773336889************************965 PP

>> DUF3989  Protein of unknown function (DUF3989)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       1.4   6.5e+03      53      77 ..     186     210 ..     185     214 .. 0.76
   2 ?   13.3   0.2   1.1e-05      0.05      31      56 ..     381     406 ..     377     439 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.4
     DUF3989  53 igredgerlqieHirrlelpvqiek 77 
                 ig +d+++lq    ++l l++  ek
  EFC38433.1 186 IGPSDKQQLQNSIKKQLYLQEIFEK 210
                 8999999999885578888866655 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 1.1e-05
     DUF3989  31 vllllllfallslYmtvssiydigre 56 
                 + +l+++fal+sl++++++iy+  r 
  EFC38433.1 381 ISILIIVFALFSLFLIFRAIYRSFRF 406
                 66899****************94443 PP

>> Reticulon  Reticulon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.18   8.3e+02      33      53 ..     382     402 ..     370     445 .. 0.59
   2 ?    5.1   1.3    0.0044        20      17      62 ..     581     626 ..     578     643 .. 0.85
   3 ?    7.8   0.3   0.00068         3      27      83 ..     699     756 ..     690     762 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.18
   Reticulon  33 sllslvsklllllllvlflwa 53 
                 s+l +v+ l+ l+l++ ++++
  EFC38433.1 382 SILIIVFALFSLFLIFRAIYR 402
                 333344444444444444433 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0044
   Reticulon  17 lgglllllllfellgysllslvsklllllllvlflwaeyagllnks 62 
                 l +++ + ++f  ++y+ +sl +  +ll l + f+wa++++ l+ s
  EFC38433.1 581 LFCIVSSCMVFTNVTYQYFSLDATNILLGLSAIFMWANIVQYLSHS 626
                 567788888999999***********************99999874 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.00068
   Reticulon  27 fellgysllslvsklllllllvlflwaeyagllnkskp...pepelelseesvreladsl 83 
                 f +   s++ ++s++ l+++++lf+++++  ++   +    +++e ++++e+++ +a+++
  EFC38433.1 699 FGQN--SVIAYFSRIYLVTFVCLFTYSVINIFILIMEDayfSVKEANIKKEAAEAAAQAI 756
                 4444..9******************99876666664334456688888888888777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (929 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1183  (0.0659825); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.91u 0.37s 00:00:01.28 Elapsed: 00:00:00.55
# Mc/sec: 5094.87
//
Query:       EFC38434.1  [L=300]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3628  (0.202354); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                       280  (0.0156172); expected 17.9 (0.001)
Passed Fwd filter:                       130  (0.00725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.81u 0.41s 00:00:02.22 Elapsed: 00:00:00.60
# Mc/sec: 1509.83
//
Query:       EFC38435.1  [L=1016]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.6e-22   76.9  12.1    0.00031   21.5   0.1    6.8  7  WD40         WD domain, G-beta repeat
    3.3e-10   40.1   0.4       0.14   12.5   0.0    5.9  6  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    0.00027   20.9   0.1        2.8    7.8   0.0    3.5  3  eIF2A        Eukaryotic translation initiation factor eIF2A
     0.0008   19.4   0.3       0.47   10.5   0.0    3.4  4  BBS2_Mid     Ciliary BBSome complex subunit 2, middle region
     0.0019   17.2   0.0       0.97    8.3   0.0    2.9  3  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
  ------ inclusion threshold ------
       0.14   12.2   0.0        2.1    8.4   0.0    2.9  3  PQQ          PQQ enzyme repeat
        0.2   11.0   6.7        7.8    5.7   0.1    3.6  3  WD40_like    WD40-like domain
        0.3   10.8   1.1         19    4.9   0.0    2.8  3  Hira         TUP1-like enhancer of split


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.2    0.0032       7.2       9      32 ..     603     628 ..     594     629 .. 0.68
   2 !   21.3   0.3   1.6e-07   0.00035       4      38 .]     643     678 ..     640     678 .. 0.83
   3 !   16.0   0.0   7.2e-06     0.016       3      38 .]     693     729 ..     691     729 .. 0.87
   4 !   21.5   0.1   1.4e-07   0.00031       3      38 .]     735     771 ..     733     771 .. 0.90
   5 ?   -2.3   0.0       4.6     1e+04      12      20 ..     801     810 ..     788     814 .. 0.60
   6 !   11.8   0.0   0.00016      0.36      12      38 .]     845     874 ..     834     874 .. 0.82
   7 ?   -0.1   0.0      0.89     2e+03      11      32 ..     893     914 ..     883     915 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0032
                 SSSSEEEEEEETTSSEEEEE..ETTS CS
        WD40   9 GHssvtslafspdgawlasG..sdDg 32 
                 G ++  ++ fs++g++la+G  s Dg
  EFC38435.1 603 GDKGCLCMEFSKSGQYLACGchSTDG 628
                 445566888*********99543576 PP

  == domain 2  score: 21.3 bits;  conditional E-value: 1.6e-07
                 EEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 + +l +H   ++s++++ d + l+++s Dgtv++W+
  EFC38435.1 643 MDVLNAHvELIYSIDWNNDDSELITASSDGTVKVWN 678
                 56788995559****9999999998877*******8 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 7.2e-06
                 EEEEEESS.SSEEEEEEETTSSEEE.EEETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawla.sGsdDgtvriWd 38 
                 +l t+  H s+v++ +f+p  + l+ +Gs+D+ +r+++
  EFC38435.1 693 LLATF-QHpSFVYCAKFHPTCKKLIiTGSYDKRIRVFN 729
                 67788.49899************855**********97 PP

  == domain 4  score: 21.5 bits;  conditional E-value: 1.4e-07
                 EEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                  +++l+GH s ++s++f+  g+ + s+s Dg ++iW+
  EFC38435.1 735 IVKELEGHtSRISSVSFDVAGTRMYSASGDGVIKIWS 771
                 6899****777*************99977*******5 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 4.6
                 S.EEEEEEET CS
        WD40  12 s.vtslafsp 20 
                 s vt+++ +p
  EFC38435.1 801 SaVTCIRSDP 810
                 359**98777 PP

  == domain 6  score: 11.8 bits;  conditional E-value: 0.00016
                 S.EEEEE..EETTSSEEEEEETTSEEEEEE CS
        WD40  12 s.vtsla..fspdgawlasGsdDgtvriWd 38 
                 + ++s++   spdg++l+sGsd g+v++W+
  EFC38435.1 845 CfINSQKsnISPDGKYLISGSDIGKVYLWN 874
                 248888899************999999997 PP

  == domain 7  score: -0.1 bits;  conditional E-value: 0.89
                 SSEEEEEEETTSSEEEEEETTS CS
        WD40  11 ssvtslafspdgawlasGsdDg 32 
                 s+v+++a+s+  + +a +s Dg
  EFC38435.1 893 SPVYDIAWSSKEHVIALCSFDG 914
                 569***9999999987445487 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       6.7   1.5e+04      61      81 ..     357     377 ..     352     382 .. 0.81
   2 !   12.5   0.0   6.3e-05      0.14      35      91 ..     601     660 ..     568     661 .. 0.78
   3 !    9.7   0.1   0.00045         1      39      71 ..     651     683 ..     647     692 .. 0.87
   4 !    9.0   0.0   0.00073       1.6       8      67 ..     714     772 ..     704     795 .. 0.84
   5 ?    3.6   0.0     0.036        81      47      74 ..     855     882 ..     850     889 .. 0.92
   6 ?    3.2   0.0      0.05   1.1e+02      37      61 ..     891     915 ..     885     937 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 6.7
  ANAPC4_WD40  61 evrlldaesgkvvhslsvkse 81 
                  +v+++d+ +g+ +++ + +++
   EFC38435.1 357 KVSVCDITTGQYLRTATLNDK 377
                  789999****99999888776 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 6.3e-05
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysd....gevrlldaesgkvvhslsvksekavtclgWge 91 
                  d+ d+   +++++++g+ La +++     g ++++d+++g ++  l+++ e  + +++W++
   EFC38435.1 601 DSGDKGCLCMEFSKSGQYLACGCHStdgiGILKIFDIYEGSIMDVLNAHVEL-IYSIDWNN 660
                  6677778899************9863333589*****************996.******85 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00045
  ANAPC4_WD40  39 sevrsLaWkpdgklLavaysdgevrlldaesgk 71 
                  + + s+ W++d++ L  a sdg+v++ ++e  k
   EFC38435.1 651 ELIYSIDWNNDDSELITASSDGTVKVWNVEYDK 683
                  56889***********************99766 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00073
  ANAPC4_WD40   8 DLiAlatedgellvfRlngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrllda 67 
                   Li  ++ d++++vf  + +++++   +++ s+++s+++   g+ +  a  dg +++ + 
   EFC38435.1 714 KLIITGSYDKRIRVFNRETNKIVKE-LEGHTSRISSVSFDVAGTRMYSASGDGVIKIWSC 772
                  5777888899999999999999887.6889999999999999999999999999999775 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.036
  ANAPC4_WD40  47 kpdgklLavaysdgevrlldaesgkvvh 74 
                  +pdgk L  + + g+v l ++e+++++ 
   EFC38435.1 855 SPDGKYLISGSDIGKVYLWNVETEELIF 882
                  69**********************9986 PP

  == domain 6  score: 3.2 bits;  conditional E-value: 0.05
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdge 61 
                  e+s v ++aW+ +++++a    dg+
   EFC38435.1 891 EESPVYDIAWSSKEHVIALCSFDGN 915
                  678999************9998886 PP

>> eIF2A  Eukaryotic translation initiation factor eIF2A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0027       6.1     105     171 ..     609     678 ..     590     682 .. 0.75
   2 ?    1.9   0.0     0.079   1.8e+02      61      98 ..     702     738 ..     686     778 .. 0.79
   3 !    7.8   0.0    0.0013       2.8      58      97 ..     891     932 ..     855     939 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0027
                 EEEE-TTSSEEEEE-TTSSS..-EEEEEETT..TTEEEEEEE-TT--EEEE-TTSSEEEEEE-TTT-SSS- CS
       eIF2A 105 tiffspkgklvllaGfgnla..Geleiwdvk..kkkkiakaeaanatlvewspdgryvlTattaprlrvdn 171
                 ++ fs++g++++ +   ++   G l+i+d    ++  + +a+ +   +++w++d++ ++Ta++   ++v n
  EFC38435.1 609 CMEFSKSGQYLACGCH-STDgiGILKIFDIYegSIMDVLNAHVELIYSIDWNNDDSELITASSDGTVKVWN 678
                 4679999999876554.4442489*****9956667777888889999**************987777655 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.079
                 .EEEEEE-TTSS-EEEEESSSSCEEEEEECSCEEEEEE CS
       eIF2A  61 pihdvaWspkskefaviyGkmpakvslfdlkvkviskl 98 
                  +++++  p+ k+ ++i G  ++++ +f+ + ++i+k 
  EFC38435.1 702 FVYCAKFHPTCKK-LIITGSYDKRIRVFNRETNKIVKE 738
                 5777777777777.5789***********998877653 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0013
                 SSS.EEEEEE-TTSS-EEEE..ESSSSCEEEEEECSCEEEEE CS
       eIF2A  58 kegpihdvaWspkskefavi..yGkmpakvslfdlkvkvisk 97 
                 +e p++d+aWs+k++ +a++   G++p +v+ f++ v++ ++
  EFC38435.1 891 EESPVYDIAWSSKEHVIALCsfDGNQPIRVYCFEKPVDQSAE 932
                 5779***********9999844599999**999998877665 PP

>> BBS2_Mid  Ciliary BBSome complex subunit 2, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.1       3.6   8.1e+03      19      40 ..     555     576 ..     546     592 .. 0.48
   2 !    5.5   0.0    0.0076        17       6      55 ..     657     704 ..     652     709 .. 0.78
   3 !   10.5   0.0   0.00021      0.47      11      70 ..     712     775 ..     703     808 .. 0.76
   4 ?   -3.6   0.0       5.2   1.2e+04      75      89 ..     901     915 ..     900     917 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.6
    BBS2_Mid  19 sddfeirvfkeeelvaeitete 40 
                  ++  + + + ee++ + +e++
  EFC38435.1 555 NNEEVVNIVQSEEIKEKKKEQS 576
                 3333344444444433333332 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0076
    BBS2_Mid   6 dvdgdgeneLvvgsddfeirvfkeeelvaeitetekvvslarlekerfay 55 
                 d ++d ++eL+ +s d +++v++  e  ++ + + k+  la+ ++ +f+y
  EFC38435.1 657 DWNND-DSELITASSDGTVKVWNV-EYDKKKSSARKPKLLATFQHPSFVY 704
                 55555.89*************975.5566667788888899888888887 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.00021
    BBS2_Mid  11 geneLvvgsddfeirvfkee..elvaeitet.ekvvsl.arlekerfayaleNGtvgvyekker 70 
                  ++ ++ gs d +irvf++e  ++v+e++ + +++ s+  ++ ++r+  a   G +++++ + r
  EFC38435.1 712 CKKLIITGSYDKRIRVFNREtnKIVKELEGHtSRISSVsFDVAGTRMYSASGDGVIKIWSCRLR 775
                 5678999**********99866899999865155655524789999999999999999887665 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 5.2
    BBS2_Mid  75 ksknevvalaaydin 89 
                 +sk++v+al+++d n
  EFC38435.1 901 SSKEHVIALCSFDGN 915
                 689999999999976 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.0    0.0032       7.2     185     221 ..     647     684 ..     601     699 .. 0.78
   2 !    8.3   0.0   0.00043      0.97     171     221 ..     726     777 ..     712     792 .. 0.81
   3 ?   -2.7   0.0      0.96   2.2e+03     192     218 ..     851     877 ..     836     880 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0032
    Ge1_WD40 185 eehs.liveaafspdGtalatasedGevkffqvylede 221
                 + h  li +  +  d   l tas+dG+vk + v   ++
  EFC38435.1 647 NAHVeLIYSIDWNNDDSELITASSDGTVKVWNVEYDKK 684
                 44543566777889999***************976654 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00043
    Ge1_WD40 171 elsveeieegllkieehs.liveaafspdGtalatasedGevkffqvylede 221
                  + + e+++ + ++e h+  i++ +f   Gt +  as dG++k +   l ++
  EFC38435.1 726 RVFNRETNKIVKELEGHTsRISSVSFDVAGTRMYSASGDGVIKIWSCRLRED 777
                 45555666677788888659*************************9988876 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 0.96
    Ge1_WD40 192 eaafspdGtalatasedGevkffqvyl 218
                 ++ +spdG  l   s  G+v ++ v  
  EFC38435.1 851 KSNISPDGKYLISGSDIGKVYLWNVET 877
                 56799****999999999999998865 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.91     2e+03       9      24 ..      47      62 ..      45      64 .. 0.86
   2 ?    8.4   0.0   0.00094       2.1       3      24 ..     716     737 ..     714     740 .. 0.86
   3 ?   -2.7   0.0       3.2   7.2e+03       3      16 ..     817     830 ..     816     831 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.91
                TSEEEEEETTTCCEEE CS
         PQQ  9 dGylyAlDadTGkvlW 24
                +G l+ ++ +TG+ + 
  EFC38435.1 47 NGELRYYNPNTGEDVT 62
                899999******9986 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00094
                 EEEEETTSEEEEEETTTCCEEE CS
         PQQ   3 vylgsadGylyAlDadTGkvlW 24 
                 ++ gs+d +++ ++++T+k++ 
  EFC38435.1 716 IITGSYDKRIRVFNRETNKIVK 737
                 5667***************985 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3.2
                 EEEEETTSEEEEEE CS
         PQQ   3 vylgsadGylyAlD 16 
                 ++++s d+ l+ lD
  EFC38435.1 817 IFVHSQDNMLRRLD 830
                 89*****9998666 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.3      0.73   1.6e+03     168     197 ..     555     584 ..     546     588 .. 0.86
   2 ?    5.7   0.1    0.0035       7.8      13      93 ..     714     795 ..     701     815 .. 0.83
   3 ?    4.2   0.0      0.01        23       7      88 ..     853     939 ..     850     956 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.73
   WD40_like 168 enkdilligtegeililkknvilqkidveg 197
                 +n++++ i +++ei+  kk++ lq+++v+ 
  EFC38435.1 555 NNEEVVNIVQSEEIKEKKKEQSLQRLKVKR 584
                 699999*****************9999875 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0035
   WD40_like  13 slilyGgkddkctvlkleslesvsivesfedSvifvkl.ldddlilvvtlDGtillslleneeevenekieedistvkvidd 93 
                 +li+ G+ d++++v++ e++++v  +e+ +  +  v + + +  +  ++ DG i     ++ e  + e+i +  +++++i+d
  EFC38435.1 714 KLIITGSYDKRIRVFNRETNKIVKELEGHTSRISSVSFdVAGTRMYSASGDGVIKIWSCRLREDSSVEDITNSFACMRTIQD 795
                 6899999999999999999999999999999999988867788999999999988766666666677888888888888776 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.01
   WD40_like   7 diskkgslilyGgkddkctvlkleslesvsive...sfedSvifvkll..dddlilvvtlDGtillslleneeevenekieedistv 88 
                 +is++g++++ G++  k+ + ++e++e++  +    +fe+S ++      ++++i  ++ DG+    +   e+ v++   +e+ s v
  EFC38435.1 853 NISPDGKYLISGSDIGKVYLWNVETEELIFKEGkdyGFEESPVYDIAWssKEHVIALCSFDGNQPIRVYCFEKPVDQSAEKENHSQV 939
                 799*************************998752237****9996554115679999*****9877887788888887777777666 PP

>> Hira  TUP1-like enhancer of split
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.8       2.6   5.9e+03     125     177 ..      32      84 ..      20      89 .. 0.46
   2 ?    3.5   0.0     0.023        52      22      47 ..     663     690 ..     649     718 .. 0.74
   3 ?    4.9   0.0    0.0084        19      12      46 ..     849     883 ..     844     889 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.6
        Hira 125 ssassasgilsalerktneevlrkgrakllqrlaktllekegfenleesvtla 177
                  ++++++ +++ + ++++ ++ + + ++ + + + +  +k++++  e++v+++
  EFC38435.1  32 RTKMKKQKVVKKMDENGELRYYNPNTGEDVTEKVLRQKKKKKTSTAENVVETE 84 
                 22233334555555555555555544444444444444445555555555544 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.023
        Hira  22 syLlavtsvgllyvWnv..kkkkvllpp 47 
                 s L+  +s+g++ vWnv  +kkk+  ++
  EFC38435.1 663 SELITASSDGTVKVWNVeyDKKKSSARK 690
                 56788899*********66444444433 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.0084
        Hira  12 spasfLessgsyLlavtsvgllyvWnvkkkkvllp 46 
                 s+ s ++  g+yL+  + +g +y Wnv++++++++
  EFC38435.1 849 SQKSNISPDGKYLISGSDIGKVYLWNVETEELIFK 883
                 555566667899999999*************9996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1016 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1304  (0.0727313); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.91u 0.34s 00:00:01.25 Elapsed: 00:00:00.55
# Mc/sec: 5603.35
//
Query:       EFC38436.1  [L=204]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (204 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1028  (0.0573373); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1213.59
//
Query:       EFC38437.1  [L=262]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (262 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      426  (0.0237604); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1598.86
//
Query:       EFC38438.1  [L=267]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.083   12.4   0.3       0.16   11.5   0.3    1.4  1  PsaF      Family of unknown function


Domain annotation for each model (and alignments):
>> PsaF  Family of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.3   8.7e-06      0.16      11      48 ..       5      44 ..       2      62 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 8.7e-06
        PsaF 11 itvmfflfl..iysfndlffysevkygdihehldlrmqgi 48
                i+v+f+lfl    sfn+l+  + +   ++h+++dl m  i
  EFC38438.1  5 ISVFFILFLccTSSFNQLVHANTIDLNNLHKQFDLVMTSI 44
                55666666521679***********************988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.35s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 1486.21
//
Query:       EFC38439.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.5    6.8   9.2        3.4    6.4   9.2    1.2  1  ALMT      Aluminium activated malate transporter


Domain annotation for each model (and alignments):
>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   9.2   0.00019       3.4     330     454 ..      20     151 ..       3     158 .. 0.63

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.00019
        ALMT 330 lkevkvaaeeLqsk..ldskskLlvnsekweaakkkekaeeveekkeeekeseskkeea......eaveeaeseseksllkeskrslklskkesapaee 420
                 l++   ++++  ++  ++s+s+ + n +++e ++++ + + +e+++e+ ++ +++++++      +++++++   +++++ e+ +++k  +++ +p+++
  EFC38439.1  20 LQNYYYGIKSFSTNcvIKSSSE-QANNNNDEVNNNNINLKIEENNSEQFNDVNNNNNSKrtigekQNRNMSKLFRKRDQTLETAKKFKDLNRKFTPSNV 117
                 5555555555544411455554.5555555555555555554444444444444444334555544445555556667777788888888899999999 PP

        ALMT 421 sleekqlskeeelkelelaealslatfaslLiel 454
                 ++ +k++++   +k+++l++ + +   as  i++
  EFC38439.1 118 EEPKKKKASPDLKKAIKLLKFMDVMEKASQGIDF 151
                 8888888888999999999999999888887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2159  (0.120419); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 1283.83
//
Query:       EFC38440.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       585  (0.0326287); expected 358.6 (0.02)
Passed bias filter:                      299  (0.0166769); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 1811.11
//
Query:       EFC38441.1  [L=441]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.1e-06   26.3   0.1      0.037   13.3   0.1    2.9  2  FAD_binding_3  FAD binding domain
     0.0033   16.7   0.0      0.009   15.3   0.0    1.7  2  Thi4           Thi4 family
  ------ inclusion threshold ------
      0.043   12.4   0.0       0.06   11.9   0.0    1.2  1  Mqo            Malate:quinone oxidoreductase (Mqo)
      0.052   12.8   0.1       0.11   11.8   0.1    1.6  1  Pyr_redox_3    Pyridine nucleotide-disulphide oxidoreductase
      0.052   13.1   0.0      0.078   12.5   0.0    1.4  1  DAO            FAD dependent oxidoreductase
       0.14   11.4   0.0       0.22   10.7   0.0    1.3  1  Pyr_redox_2    Pyridine nucleotide-disulphide oxidoreductase


Domain annotation for each model (and alignments):
>> FAD_binding_3  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.0   0.00014      0.41       2      51 ..      21      71 ..      20     124 .. 0.80
   2 !   13.3   0.1   1.2e-05     0.037     154     172 ..     130     148 ..     117     314 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00014
                   EEEEEE--SHHHHHHH...HHHHHTTHHEEEEESSSSSCCSSS--EEEHHHHH CS
  FAD_binding_3  2 tdVlIVGaGpaGlmla...llLseaGvrvvlvekrsttvvlpradglnqrtme 51
                   +d+++VGaGp+Gl ++   +lL  +  + +++ek+++ ++ +   +l+ +++e
     EFC38441.1 21 IDIVVVGAGPVGLWTScqiKLLNPK-LNIRILEKHEE-YKRSHVVVLHHKSLE 71
                   6899**********99554577777.89999999975.455566666666665 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 1.2e-05
                    EEEEEEE--GTT-HHHHHH CS
  FAD_binding_3 154 rakYlvGaDGgrStvrktl 172
                    +a++++GaDG +Stvr ++
     EFC38441.1 130 NARFIIGADGSHSTVRGAV 148
                    59**************886 PP

>> Thi4  Thi4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0     3e-06     0.009      15      50 ..      18      54 ..       6      57 .. 0.81
   2 ?   -3.4   0.0       1.5   4.6e+03     104     124 ..     101     121 ..      83     129 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 3e-06
                HTEEEEEEE--SHHHHHHHHHHHHC.TTS-EEEEESS CS
        Thi4 15 yaesDvvivGaGssGLtaayylakk.pdlkvailers 50
                    D+v+vGaG+ GL ++  +    p+l++ ile++
  EFC38441.1 18 NSTIDIVVVGAGPVGLWTSCQIKLLnPKLNIRILEKH 54
                4568************8888887655*********86 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.5
                 HHHHHTSTTEEEEESEEEEEE CS
        Thi4 104 lskvlqlanvkllnavaveDl 124
                 ls++++  n+ +++   v+D+
  EFC38441.1 101 LSNLCKELNIEIFKNFNVNDM 121
                 455666666777776666665 PP

>> Mqo  Malate:quinone oxidoreductase (Mqo)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0     2e-05      0.06       2      73 ..      20      92 ..      19     143 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2e-05
         Mqo  2 kvdvvliGaGimsatlgvllkelepelsievlerldkvaeessna.wnnaGtGHsalcElnYtpekedgsidi 73
                ++d+v++GaG +    +  +k l+p+l+i++le+ ++  +       + +  GH a   ln   ++  ++ +i
  EFC38441.1 20 TIDIVVVGAGPVGLWTSCQIKLLNPKLNIRILEKHEEYKRSHVVVlHHKSLEGHVAHPTLNNFRKEVTENTKI 92
                57*********************************99877665541456678999988888766655544444 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   3.6e-05      0.11       1     114 [.      24     128 ..      24     168 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.6e-05
  Pyr_redox_3   1 iIiGaGPaGlaaaielkkagl.edylilEkgnignsiyrypkemtfispsftsekleipdlnaiseetspafslkeeklsrkealeYlrevaksfelp 97 
                  +++GaGP Gl + +++k ++   ++ ilEk++  +  +    + + +       ++  p ln++ +e       +++k++++ + + l++++k+ +++
   EFC38441.1  24 VVVGAGPVGLWTSCQIKLLNPkLNIRILEKHEEYKRSHVVVLHHKSLE-----GHVAHPTLNNFRKEVT-----ENTKIRTNRIEQTLSNLCKELNIE 111
                  79********8777766654323899****975544444444444444.....2355566666665554.....467788888888888888888888 PP

  Pyr_redox_3  98 iklfeeVesvkkedegf 114
                  i ++ +V+++k+ ++ f
   EFC38441.1 112 IFKNFNVNDMKSIESMF 128
                  88888888887766555 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   2.6e-05     0.078       1      31 [.      22      56 ..      22     127 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.6e-05
                EEEEECTSHHHHHHHHHHHHT.T...EEEEESSSS CS
         DAO  1 dvviiGGGiiGlstAyeLarr.g...Vtllekgdi 31
                d+v++G+G +Gl+t  +     +   + +lek+++
  EFC38441.1 22 DIVVVGAGPVGLWTSCQIKLLnPklnIRILEKHEE 56
                9*****************64434799999999965 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   7.3e-05      0.22       2      58 ..      22      92 ..       7     156 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 7.3e-05
                 SEEEE--SHHHHHHHHHHHH..HTS-EEEEE..TTHCHHHCSHHHHCHHHHHHHHHHHHH..........H CS
                 xxxxxxxxxxxxxxxxxxxx..xxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxx..........x RF
  Pyr_redox_2  2 dvvviGgGpAGlaaaltlaq..agakvtlve..legtclnggcllskallgvaedaeias..........e 58
                 d+vv+G+Gp Gl+++ +++    ++++ ++e  +e    ++ +l +k l+g  +++               
   EFC38441.1 22 DIVVVGAGPVGLWTSCQIKLlnPKLNIRILEkhEEYKRSHVVVLHHKSLEGHVAHPTLNNfrkevtentkI 92
                 67777777777765554444325777777765544444444455566666666666544466655544441 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       676  (0.0377043); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2562.12
//
Query:       EFC38442.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0052   16.5   7.7     0.0052   16.5   7.7    3.3  3  Ephrin_rec_like  Putative ephrin-receptor like
  ------ inclusion threshold ------
       0.51   10.6   3.4        1.1    9.5   3.4    1.6  1  DIM              DIM protein
        1.2    9.6  10.9        0.8   10.2   1.6    2.9  3  TNFR_c6          TNFR/NGFR cysteine-rich region


Domain annotation for each model (and alignments):
>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   6.8     0.031   1.8e+02      10      37 ..      21      44 ..      15      50 .. 0.69
   2 !   16.5   7.7   8.7e-07    0.0052      12      41 ..      50      79 ..      43      83 .. 0.88
   3 ?    2.1   1.1     0.028   1.7e+02       5      23 ..      76      91 ..      73      98 .. 0.61

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.031
  Ephrin_rec_like 10 tCipCprgtYqneegqlsClaCPlgttt 37
                     tC +Cp g Y   + +++C++C +g++ 
       EFC38442.1 21 TC-ACPPGMY---IANSQCKPCSPGNYC 44
                     55.5888888...456788888888765 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 8.7e-07
  Ephrin_rec_like 12 ipCprgtYqneegqlsClaCPlgtttkkpg 41
                      pCp gt +  +gq++C+aCP +  t +++
       EFC38442.1 50 KPCPAGTINTDVGQTTCQACPKNYITNQQH 79
                     59*******************999998876 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.028
  Ephrin_rec_like  5 ntgletCipCprgtYqnee 23
                     n+++  CipC    Y+ +e
       EFC38442.1 76 NQQHTACIPCH---YRTNE 91
                     56777888884...55555 PP

>> DIM  DIM protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   3.4   0.00019       1.1       4      36 .]       6      39 ..       1      39 [. 0.89

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00019
         DIM  4 LsLlaflllllalaaanal.pGkViINGkCkdCN 36
                + L af+l + + ++++a  pG  i N +Ck C+
  EFC38442.1  6 IALIAFILSCQLALVTCACpPGMYIANSQCKPCS 39
                5678*****88********9*************7 PP

>> TNFR_c6  TNFR/NGFR cysteine-rich region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   1.6   0.00013       0.8       1      31 [.      24      52 ..      24      60 .. 0.68
   2 ?    0.1   2.2      0.18   1.1e+03       1      23 [.      52      71 ..      52      82 .. 0.55
   3 ?    4.4   1.0    0.0084        50       1      19 [.      69      86 ..      69      89 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00013
                --TTEECCCTCTCSEEEEE-...BGCTEEECC-- CS
     TNFR_c6  1 CpegtYtdnenskeClpCtr...CppgqvvlrpC 31
                Cp+g Y  n  s+ C+pC++   C     +++pC
  EFC38442.1 24 CPPGMYIAN--SQ-CKPCSPgnyC--LNDESKPC 52
                ******665..46.9999765556..44444555 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.18
                --TTEE.CCCTCTCSEEEEE-BGC CS
     TNFR_c6  1 CpegtY.tdnenskeClpCtrCpp 23
                Cp gt  td   +  C   + Cp+
  EFC38442.1 52 CPAGTInTDVGQTT-C---QACPK 71
                56666434444444.5...55555 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.0084
                --TTEECCCTCTCSEEEEE CS
     TNFR_c6  1 CpegtYtdnenskeClpCt 19
                Cp+++ t+++++  C pC+
  EFC38442.1 69 CPKNYITNQQHTA-CIPCH 86
                8999558888888.****5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       758  (0.0422779); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.57
# Mc/sec: 1751.89
//
Query:       EFC38443.1  [L=164]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       878  (0.0489709); expected 358.6 (0.02)
Passed bias filter:                      645  (0.0359752); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 982.25
//
Query:       EFC38444.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-34  117.8   0.0    9.5e-34  116.6   0.0    1.6  1  Cupin_5   Cupin superfamily (DUF985)


Domain annotation for each model (and alignments):
>> Cupin_5  Cupin superfamily (DUF985)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  116.6   0.0   5.3e-38   9.5e-34       1     139 [.      15     192 ..      15     194 .. 0.82

  Alignments for each domain:
  == domain 1  score: 116.6 bits;  conditional E-value: 5.3e-38
                 HHHHHHTT-EEBTTSSEEEEEEE.SSEEE.CSS................STC.CES-EEEEEEEETTBEEEEEEESSEEEEEEEEES-.EEEEEESTT. CS
     Cupin_5   1 qeliaklnLephpegGyfretdrseltvpsskl...............edgkeRsasTaIyylltsgevsalhrvksdevwhyhaGrp.Lrlvllhad. 82 
                 q++++k++L ph+egGy++e++r++l+v+ +++               + +++Rs+sT+I+yll  g++s++h +ks e why++G++ L +++l+++ 
  EFC38444.1  15 QYFVKKYKLLPHVEGGYYSEIFRNPLSVNIQNSstssdstissassenSVENQRSLSTSIFYLLGGGDFSCFHSIKSFEQWHYYTGSCnLIIHVLDPQt 113
                 678*********************99999888889**********99978889*********************************9867778887734 PP

                 SCEEEEEESS-TTTTE......................BSEEEE-TTSEEEEEESSSSTSSEEEEEEEESSC--GGGEE CS
     Cupin_5  83 grvetvvlGpdvaage......................klqlvVpagkwkaaellgddeeeylLvsctvaPGFefedfe 139
                 +r+ ++vl ++ + ++                      +l++++p+++w+aael++++ e+y++ +ctv+ GF+f+df 
  EFC38444.1 114 KRYGKFVLNNRPNVESdlslqqedlltphwgsekveltNLSCFIPENWWFAAELEDKSPENYVMAGCTVSFGFDFRDFA 192
                 55555555444333223333334444444444445555888***************999******************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       592  (0.0330191); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.34s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1272.04
//
Query:       EFC38445.1  [L=882]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-17   62.0   5.8    1.2e-09   38.4   0.8    4.5  3  BTB       BTB/POZ domain
    3.8e-10   39.6   0.2    2.4e-06   27.4   0.0    3.0  2  Kelch_4   Galactose oxidase, central domain
    3.2e-09   36.5   0.2    7.7e-05   22.6   0.0    2.8  2  Kelch_5   Kelch motif
      4e-05   23.7   0.1       0.12   12.7   0.0    3.1  3  Kelch_6   Kelch motif
    4.6e-05   23.6   0.0     0.0089   16.3   0.0    2.7  2  Kelch_3   Galactose oxidase, central domain
    5.5e-05   23.0   0.9     0.0027   17.6   0.2    2.7  2  Kelch_2   Kelch motif


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.63   1.9e+03      32      47 ..     155     170 ..     141     182 .. 0.74
   2 !   21.1   0.1   9.6e-08   0.00029       3      95 ..     544     656 ..     542     680 .. 0.84
   3 !   38.4   0.8   4.1e-13   1.2e-09      22     100 ..     731     807 ..     690     850 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.63
                 HH-HHHHHHHTSTTTT CS
         BTB  32 arSpyFkalftskeie 47 
                 arS++Fk+ f++ +++
  EFC38445.1 155 ARSKIFKEPFKNFTEA 170
                 89*********99433 PP

  == domain 2  score: 21.1 bits;  conditional E-value: 9.6e-08
                 HHHHHTTTS-EEEEETT.....TEEEEE-HHHHHHH-HHHHHHHTST............TTTTCCCE......EEEETTSGHH...HHHHHHHHHHHSE CS
         BTB   3 elresgelcDvtlvvgd.....gkefkahkavLaarSpyFkalftsk............eieessvs......eielddvepe...afealLefiYtge 75 
                 e r++  ++D++++++d        + ahk+v  ar p +++ ++++                          +i+l  v p    +f+  L+f+Y+ge
  EFC38445.1 544 EKRNEYYMVDMAFKLEDslndlSDYILAHKCVILARCPGLYKYIEETnqelekeefigvI------FpnddkaTIPLVRVLPGyepVFKTYLDFLYCGE 636
                 56777789999999999999998999*********************7766655555552......04444448888888884445************* PP

                 EEC-CGGGHHHHHHHHHHHT CS
         BTB  76 leitseenleelLaaadllq 95 
                 + +t+ +n++ lL +a++l 
  EFC38445.1 637 IIVTEAKNVPLLLDLARILS 656
                 ****99**********9985 PP

  == domain 3  score: 38.4 bits;  conditional E-value: 4.1e-13
                 EEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHH CS
         BTB  22 efkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlk 100
                  + +h+++L+ rSpy+++ f   +++e+ ++++++++ +++af++++ef Yt++++++  +n  ++L   +l+++++l 
  EFC38445.1 731 ALNVHRLFLS-RSPYLSRVFVTSRMSEAMSNVVYMEEYSYDAFKKMVEFFYTDKIQLD-GQNCLATLIYSSLFECEDLL 807
                 5789****96.9***********99999999**************************7.9**************99975 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0   0.00049       1.5       2      33 ..     350     381 ..     349     388 .. 0.88
   2 !   27.4   0.0   8.1e-10   2.4e-06       1      45 [.     405     448 ..     405     456 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00049
     Kelch_4   2 RaghsatsipdgtiylfGGrgedgtllndlyl 33 
                 R ++s+ s+++  iy+fGG   +g+l+n l+ 
  EFC38445.1 350 RSDYSVNSTNGSFIYVFGGVEKNGKLSNALFM 381
                 8899*****999********999999887765 PP

  == domain 2  score: 27.4 bits;  conditional E-value: 8.1e-10
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtllndlylldlstntWrrl..g 45 
                 pR  hs++ i   +++++GG+ge+g++lndly+  +++++W ++   
  EFC38445.1 405 PRYKHSSCMII-SDLFIYGGIGENGKVLNDLYR--FKDGKWVEIivD 448
                 78888888883.57999****************..******776562 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.9   0.0   0.00012      0.35      12      38 ..     358     383 ..     346     388 .. 0.77
   2 !   22.6   0.0   2.6e-08   7.7e-05       2      36 ..     403     436 ..     402     438 .. 0.96

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00012
     Kelch_5  12 tvsekiYvyGGkvgrdgsvsddvyvLd 38 
                 t ++ iYv+GG+   +g++s+ ++ L+
  EFC38445.1 358 TNGSFIYVFGGVE-KNGKLSNALFMLT 383
                 33467********.5*******99985 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 2.6e-08
     Kelch_5   2 PppRaghcavtvsekiYvyGGkvgrdgsvsddvyv 36 
                 P+pR+ h++++  + +++yGG++ ++g+v +d+y+
  EFC38445.1 403 PCPRYKHSSCMIISDLFIYGGIG-ENGKVLNDLYR 436
                 ***********************.8*********8 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.7   8.2e+03       9      22 ..     271     284 ..     266     292 .. 0.74
   2 !    7.5   0.0    0.0018       5.4       2      28 ..     350     377 ..     349     382 .. 0.72
   3 !   12.7   0.0   4.1e-05      0.12       1      42 [.     405     444 ..     405     454 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.7
     Kelch_6   9 svggkiYifGGytd 22 
                    + i if+G   
  EFC38445.1 271 KFADNILIFCGDHS 284
                 566889*****865 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0018
     Kelch_6   2 raghslvsvgg.kiYifGGytdsspyln 28 
                 r  +s+ s +g +iY+fGG    ++ +n
  EFC38445.1 350 RSDYSVNSTNGsFIYVFGGVEKNGKLSN 377
                 5667887877659******876555555 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 4.1e-05
     Kelch_6   1 praghslvsvggkiYifGGytdsspylnkvwvydpetksWeq 42 
                 pr+ hs++ + + ++i+GG +  ++ ln+++++  ++++W +
  EFC38445.1 405 PRYKHSSCMIISDLFIYGGIGENGKVLNDLYRF--KDGKWVE 444
                 6899****************999******9888..8899987 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.016        47       1      29 [.     360     387 ..     360     413 .. 0.75
   2 !   16.3   0.0     3e-06    0.0089       4      37 ..     418     450 ..     416     462 .. 0.75

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.016
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtn 29 
                 g ++y+fGG    +++ +n+++++  +t+
  EFC38445.1 360 GSFIYVFGGVE-KNGKLSNALFMLTRSTT 387
                 5689*****99.89********9988876 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 3e-06
     Kelch_3   4 lyifGGlgddgqdrlndvyvydldtntWaei..asl 37 
                 l+i+GG g  ++++lnd+y++  +  +W ei  +sl
  EFC38445.1 418 LFIYGGIG-ENGKVLNDLYRFKDG--KWVEIivDSL 450
                 9*******.79**********999..6666666443 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.037   1.1e+02      12      27 ..     361     375 ..     353     393 .. 0.76
   2 !   17.6   0.2   9.1e-07    0.0027       1      41 [.     405     443 ..     405     443 .. 0.97

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.037
     Kelch_2  12 gkiyvvGGahtdnpnl 27 
                 + iyv+GG+ + n+ l
  EFC38445.1 361 SFIYVFGGV-EKNGKL 375
                 559******.444433 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 9.1e-07
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhv 41 
                 +r+ hss+++ + ++++GG+  ++++ + +d++ + ++k+v
  EFC38445.1 405 PRYKHSSCMIISDLFIYGGI--GENGKVLNDLYRFKDGKWV 443
                 79******************..****************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (882 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1319  (0.073568); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.79u 0.33s 00:00:01.12 Elapsed: 00:00:00.52
# Mc/sec: 5083.84
//
Query:       EFC38446.1  [L=453]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.6e-21   76.5   0.0    2.9e-21   75.6   0.0    1.5  1  Yippee-Mis18  Yippee zinc-binding/DNA-binding /Mis18, centrom
  ------ inclusion threshold ------
      0.042   14.3   2.3      0.071   13.6   2.3    1.3  1  Fez1          Fez1
      0.056   13.7   0.0       0.12   12.7   0.0    1.5  1  RIG-I_C-RD    C-terminal domain of RIG-I
       0.16   12.5   2.6       0.28   11.7   1.8    1.7  1  Spectrin      Spectrin repeat
       0.31   10.9   0.1       0.31   10.9   0.1    1.7  2  TFIIS_C       Transcription factor S-II (TFIIS)


Domain annotation for each model (and alignments):
>> Yippee-Mis18  Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.6   0.0   8.1e-25   2.9e-21       1     103 [.     190     296 ..     190     298 .. 0.94

  Alignments for each domain:
  == domain 1  score: 75.6 bits;  conditional E-value: 8.1e-25
                   EEEEETTTS-EEEECCCEEEEECCCEEEES---CCCEEEECEEEETTSTT....EEEEEEEETTT--EEEEEEEECSCC.CCCCCTCEEEEGGGEEE CS
  Yippee-Mis18   1 lvfqCkkCktilgdslqlvsegralnivvlkkvtrnvvvgkelvtdeegk....ctystlsCkgCnsvlGwkYksteee.lkykrglfiletkaits 92 
                   lvf+Ck+C+ti+ ds++l+ +g+++ i+++ kv+ +v v++++++  +++    ++y++l+Ck+C++ +G+kY +  ++ + +++g+++l+++a++ 
    EFC38446.1 190 LVFSCKHCRTIFIDSNALFFNGEEHGIITFLKVH-KVEVRENVQIAPNDRfdagSNYYPLFCKQCQTLVGRKYLMSDKSpIVDIIGYYTLDIDALSL 285
                   59*******************************6.9**********5544589******************************************** PP

                   EESSSSXXXXX CS
  Yippee-Mis18  93 yslgekeeeke 103
                   y+++++e+e+ 
    EFC38446.1 286 YEMWTAEQETG 296
                   ******99875 PP

>> Fez1  Fez1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   2.3     2e-05     0.071      11      96 ..     318     402 ..     316     449 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2e-05
        Fez1  11 EislLKqQLkdsqaevtqklseivalkaqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeel 96 
                 Ei lLK+ L   q +++++++ei  lk ++  +  k + + ++i el +++   ++el+  ++e ++ ++ +  l+++v+++++e+
  EFC38446.1 318 EITLLKNALLMLQHNQSSQGKEIHLLKQEINGTVDKND-SVKKIPELIQKMARIEKELNISQEEQKKISHINRRLNNEVGHIKKET 402
                 9**************************99887777644.45789999999999999999999999999999999999999988875 PP

>> RIG-I_C-RD  C-terminal domain of RIG-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   3.2e-05      0.12       3      74 ..     192     264 ..     190     291 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.2e-05
  RIG-I_C-RD   3 llCkkCkkevcsssdirvienshhvvvnpefkelvkvkekkk..kekkfedfekkgkikCkkCkkdwGimmkyk 74 
                 ++Ck+C++ + +s+ +    + h +++  ++ ++v+v+e+++   +++f+  +    ++Ck+C++ +G  + + 
  EFC38446.1 192 FSCKHCRTIFIDSNALFFNGEEHGIITFLKV-HKVEVRENVQiaPNDRFDAGSNYYPLFCKQCQTLVGRKYLMS 264
                 79**************986666655555554.5555554544115677788889999***********988775 PP

>> Spectrin  Spectrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   1.8   7.9e-05      0.28      26      76 ..     350     400 ..     334     406 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7.9e-05
                 CSSCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTHTTHH CS
    Spectrin  26 sedlgkdleevqallkkhkaleaelaaqqervkalnelaeklldeghsase 76 
                 + d+  ++ ++ +l++k+ ++e+el+  qe+ k++ ++ ++l +e ++ ++
  EFC38446.1 350 TVDKNDSVKKIPELIQKMARIEKELNISQEEQKKISHINRRLNNEVGHIKK 400
                 45778899999*******************************776655444 PP

>> TFIIS_C  Transcription factor S-II (TFIIS)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   8.6e-05      0.31      11      36 ..     175     199 ..     171     201 .. 0.78
   2 ?   -3.6   0.7       3.1   1.1e+04      31      35 ..     250     254 ..     249     255 .. 0.54

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8.6e-05
     TFIIS_C  11 ayffqlQtRsaDEpmtvfykCtkCgh 36 
                 a+  +  tR++DEp+ vf  C+ C  
  EFC38446.1 175 ATIEEPRTRASDEPQLVF-SCKHCRT 199
                 5566667********997.7999976 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 3.1
     TFIIS_C  31 CtkCg 35 
                 C++C+
  EFC38446.1 250 CKQCQ 254
                 55554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (453 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1272  (0.0709465); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 2582.38
//
Query:       EFC38447.1  [L=229]
Description: enoyl-CoA hydratase-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-40  138.5   0.0    2.9e-38  131.6   0.0    2.0  1  ECH_1     Enoyl-CoA hydratase/isomerase
    2.9e-21   76.4   0.0    9.8e-17   61.4   0.0    2.1  2  ECH_2     Enoyl-CoA hydratase/isomerase


Domain annotation for each model (and alignments):
>> ECH_1  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.6   0.0   3.3e-42   2.9e-38      27     250 ..       4     228 ..       1     229 [] 0.92

  Alignments for each domain:
  == domain 1  score: 131.6 bits;  conditional E-value: 3.3e-42
                 HHHHHHHHHH...HSTTECEEEEEE.BTSEEEEEB-HHHHHHHHCHHHHHHHCCHHHHHHHHHHSSSEEEEEE-SEEETHHHHHHHHSSEEEEETTTE. CS
       ECH_1  27 Eliqalekle...ddksvravvLtG.gdkaFaaGadlkemaeeekakqallkeevlelwtklytvpkpviaavnGaaigGGlelalacDiviaadnas. 120
                 El+  le ++   +++ +r  ++ +   + F+aGadlke+ +  + +  ++  ++ +l++ + ++p+p+iaa+nG+++gGG+el lacD+++  +n   
  EFC38447.1   4 ELLSCLEFIKfnhTEQGIRCLIINSaVKGTFCAGADLKERSQMTQTQTSQFVTKLRNLMNDIENLPIPTIAAINGYCLGGGMELSLACDFRVGVQNKDv 102
                 555555544322267789************************99999999******************************************9999877 PP

                 ........EE-GGGGGTS--CTTCHHHHHHHHHHHHHHHHHHHT-EEEHHHH.HHCTSSSEEESGGGHHHHHHHHHHHHHHSCHHHHHHHHHHHHHHHH CS
       ECH_1 121 ........fglnelklGlipgaggtqilarkvGkskAeeilllgkkisaqea.lkvGlvdkvvpeeqlleealelaeklaekspaalrqlkealnakle 210
                         +gl e+ l +ipgaggtq+l+r +G  kA+e+++++kki++qea +k G+ +                + + +++p a++++k+++++ ++
  EFC38447.1 103 eleklpgyYGLVETALAIIPGAGGTQRLPRLIGVPKAKELIYTAKKINVQEAyEKYGILND-------------YGKPISQNGPIAVKMAKQSIQQGIQ 188
                 88889999********************************************5578*9985.............5788999****************** PP

                 HHHHHHHHHHHHHHHHHCTSHHHHHHHHHHHTCSH----- CS
       ECH_1 211 dalaeqleaeaklfestfskddikeGlqaflEkrkpefed 250
                   la++++ e   + +++ ++d+ eGl+af Ekrkp +++
  EFC38447.1 189 LDLANAMKTEELCYAQVIPTKDRIEGLTAFREKRKPVYKG 228
                 *************************************996 PP

>> ECH_2  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.4   0.0   1.1e-20   9.8e-17      20     163 ..       2     155 ..       1     166 [. 0.82
   2 !   13.3   0.0   4.9e-06     0.044     254     307 ..     166     218 ..     155     228 .. 0.87

  Alignments for each domain:
  == domain 1  score: 61.4 bits;  conditional E-value: 1.1e-20
                 HHHHHHHHHHH...CC-TT-SEEEEEESSSSECE--B--HHHHHHHHCS-THHHHHHHHHHHHHHHHHC-SS-EEEEE-BEEETHHHHHHTTSSEEEE- CS
       ECH_2  20 vralkealkew...ekddevklvvlkgagekafCAGgDvralyeaakegkkeeeeffreeYklnyliatypkpvvalmdGivmGgGvGlsvhgsfrvvt 115
                 v++l ++l+ +   ++++ ++++++++a +  fCAG D+++  +  +++++   +f+++  +l + i+++p p++a ++G+++GgG+ ls+ + frv  
  EFC38447.1   2 VNELLSCLEFIkfnHTEQGIRCLIINSAVKGTFCAGADLKERSQMTQTQTS---QFVTKLRNLMNDIENLPIPTIAAINGYCLGGGMELSLACDFRVGV 97 
                 5555555544322267899**********************9998888553...5******************************************99 PP

                 TT-.........EEE--GGGGT----TTHHHHHHCSST.THHHHHHHH---B-HHHHH CS
       ECH_2 116 ert.........vfAmPEtaIGlfPDvGgsyfLsrlpg.elGlylalTGarlkgadal 163
                 ++               Eta+ ++P  Gg+  L+rl g   ++ l  T+++++ ++a+
  EFC38447.1  98 QNKdveleklpgYYGLVETALAIIPGAGGTQRLPRLIGvPKAKELIYTAKKINVQEAY 155
                 88733333333335678******************98767889999999999998887 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 4.9e-06
                 HHHHHS-HHHHHHHHHHHHHHTTT--HHHHHHHHHHHHHHHHHHSSHHHHHHHH CS
       ECH_2 254 etlkkrsPtslkvtleqlrrgrklsslaevlrmElrlalrllaekDfveGvral 307
                 + ++++ P+++k++ +++++g +l +la+++++E    ++++ +kD +eG +a 
  EFC38447.1 166 KPISQNGPIAVKMAKQSIQQGIQL-DLANAMKTEELCYAQVIPTKDRIEGLTAF 218
                 678999******************.5************************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       559  (0.0311785); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1416.26
//
Query:       EFC38448.1  [L=718]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.89    9.7   0.0       0.89    9.7   0.0    3.5  4  PknG_rubred  Protein kinase G rubredoxin domain


Domain annotation for each model (and alignments):
>> PknG_rubred  Protein kinase G rubredoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.3      0.18   3.2e+03       8      13 ..      50      55 ..      14     106 .. 0.55
   2 ?   -3.3   1.0      0.51   9.1e+03      37      45 ..     167     175 ..     132     208 .. 0.43
   3 ?   -2.1   3.8      0.22   3.9e+03       7      56 ..     256     303 ..     247     316 .. 0.46
   4 ?    9.7   0.0   4.9e-05      0.89      83     112 ..     569     598 ..     567     608 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.18
                 XXXXXX CS
  PknG_rubred  8 dlesas 13
                  +++as
   EFC38448.1 50 HQQEAS 55
                 112222 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.51
                  XXXXX.XXX CS
  PknG_rubred  37 aslealste 45 
                  ++++++++ 
   EFC38448.1 167 QPAHSSDHV 175
                  222222221 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.22
                  .XXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXX.XXXXXXXXXXXXXX CS
  PknG_rubred   7 edlesasaatarpvstqavfRpev...dddedsaslealsteastrsasatrs 56 
                  +d++ +s++t  + s++   + e    dd+++++s+e+ ++  st +     +
   EFC38448.1 256 KDVAGESSSTLNSNSSEDAKKTETmltDDKTNNQSNETNANVISTSR-----N 303
                  36666666666666554444444313344444444433333332222.....2 PP

  == domain 4  score: 9.7 bits;  conditional E-value: 4.9e-05
                  -CSS---GGG-B-TTT--B-S---SS---- CS
  PknG_rubred  83 ltnpvvpEskRfCwrCGrpvGRsekerkga 112
                  l+ p + EskR C++C ++  R+++++k++
   EFC38448.1 569 LKTPLLGESKRICANCYHKKYRNSRKKKAD 598
                  678999***********9999999988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (718 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1812  (0.101065); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.98u 0.37s 00:00:01.35 Elapsed: 00:00:00.58
# Mc/sec: 3709.99
//
Query:       EFC38449.1  [L=643]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.032   14.4   0.8      0.094   12.9   0.8    1.7  1  Cnn_1N           Centrosomin N-terminal motif 1
       0.14   12.2   3.8       0.43   10.6   3.8    1.8  1  TMF_DNA_bd       TATA element modulatory factor 1 DNA binding
        2.3    8.5  10.6          4    7.7   0.8    3.4  2  Ribosomal_L31    Ribosomal protein L31


Domain annotation for each model (and alignments):
>> Cnn_1N  Centrosomin N-terminal motif 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.8   1.6e-05     0.094      25      63 ..     309     349 ..     306     360 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.6e-05
      Cnn_1N  25 fLeerleklse..eqkeellkenielkveveslqkelkekk 63 
                 f+ee ++kl+     ++ l+keni lk e+ s  ++++++ 
  EFC38449.1 309 FMEELQQKLRHqdAIIKRLEKENIRLKNELDSFNRSINQYS 349
                 66666666666545678888888888888888888887775 PP

>> TMF_DNA_bd  TATA element modulatory factor 1 DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   3.8   7.2e-05      0.43      22      64 ..     311     353 ..     310     361 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 7.2e-05
  TMF_DNA_bd  22 ekLskkelklnntikkLrkknkelekeikelkkkleklekele 64 
                 e+L+ k +++ ++ik+L k+n  l +e+++ ++ +++++++ +
  EFC38449.1 311 EELQQKLRHQDAIIKRLEKENIRLKNELDSFNRSINQYSSSGN 353
                 8999********************************9998765 PP

>> Ribosomal_L31  Ribosomal protein L31
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.8   0.00067         4      28      56 ..     117     152 ..      90     155 .. 0.70
   2 ?    3.2   3.2     0.018   1.1e+02      22      51 ..     210     235 ..     179     240 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00067
  Ribosomal_L31  28 l.......kekpeikvdvcsksHPfYtGkqklvdta 56 
                             + ++++  v s++HP Yt ++++ ++a
     EFC38449.1 117 SdsyhgsnYQTSLYSSAVQSNNHPSYTSNATVSNAA 152
                    04444443556779999**********999887765 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.018
  Ribosomal_L31  22 fltrStlkekpeikvdvcsksHPfYtGkqk 51 
                     + +St    p+++v ++s+ H ++   q+
     EFC38449.1 210 TNLQST----PSVTVATSSSVHSMWSSAQQ 235
                    334455....***************98775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (643 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2258  (0.125941); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.12u 0.42s 00:00:01.54 Elapsed: 00:00:00.63
# Mc/sec: 3086.00
//
Query:       EFC38450.1  [L=732]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.5e-10   38.6   1.0    8.5e-10   38.6   1.0    2.8  3  PX             PX domain
  ------ inclusion threshold ------
      0.024   14.8   0.2       0.11   12.7   0.2    2.2  1  DUF2543        Protein of unknown function (DUF2543)
       0.07   13.2   2.1      0.081   13.0   0.2    2.1  2  DUF2603        Protein of unknown function (DUF2603)
       0.27   10.7   1.9        0.3   10.5   0.1    1.9  2  Peptidase_M75  Imelysin
       0.34   11.4   5.5       0.15   12.5   0.4    3.1  4  DASH_Dad2      DASH complex subunit Dad2


Domain annotation for each model (and alignments):
>> PX  PX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.6   1.0   2.4e-13   8.5e-10      24     111 ..      31     139 ..      12     141 .. 0.85
   2 ?   -2.8   0.0       1.7   6.2e+03      85     106 ..     393     414 ..     382     415 .. 0.75
   3 ?   -2.6   0.0       1.5   5.4e+03      70      97 ..     547     574 ..     517     587 .. 0.58

  Alignments for each domain:
  == domain 1  score: 38.6 bits;  conditional E-value: 2.4e-13
                 EEEEETTS......SSEEEEEEEHHHHHHHHHHHHHHHT..............TSTSTSSSTSGSSSSSCTTSHHHHHHHHHHHHHHHHHHHTSCHHHH CS
          PX  24 yevelktg......akewtvkRrYsdFeeLhskLlrkfp..............rvkiPplPkkvlfgsvrkkdeefiekrrkgLeeyLqrllnhpelrn 102
                 +++++k +      +++ tv +rYs++ eLh+k+l++                  +  ++P+k lfg+   +++e i kr+ +L++y+ ++ ++p++++
  EFC38450.1  31 IRCSYKAKtsslsnEQSYTVIKRYSEILELHKKILKQLGkrltsnnekksnsnIEEGLKFPGKLLFGN---FKDENIMKRKDELQKYFDQITSMPMITQ 126
                 4444444456677799**********************************775556789********8...***************************9 PP

                 ....SHHHHHHHH CS
          PX 103 ....sevlteFLe 111
                     +++++ F+ 
  EFC38450.1 127 dplaCQIIYAFFR 139
                 7777888888875 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.7
                 HHHHHHHHHHHTSCHHHHSHHH CS
          PX  85 kgLeeyLqrllnhpelrnsevl 106
                 + L++y+ +l++++ +++ e++
  EFC38450.1 393 SLLKKYFSELASNNPITQREEF 414
                 6688999999999888876665 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.5
                 SSSCTTSHHHHHHHHHHHHHHHHHHHTS CS
          PX  70 gsvrkkdeefiekrrkgLeeyLqrllnh 97 
                 +++  +d+++  + r++ e+++++ + h
  EFC38450.1 547 SQKSENDNNVDIQMRQYAEKFFTEKMPH 574
                 3323444555555566666666665555 PP

>> DUF2543  Protein of unknown function (DUF2543)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2   3.1e-05      0.11       3      50 ..     554     600 ..     552     603 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.1e-05
     DUF2543   3 neiplkyydiadeyatesaePvseeerdalahyfqllitrltnneeis 50 
                 n++ ++    a+++ te + P s+e r+ala+ fq  +  l+nn+ ++
  EFC38450.1 554 NNVDIQMRQYAEKFFTE-KMPHSDETREALARAFQSELQSLSNNDIVN 600
                 56666666778888888.57************************8765 PP

>> DUF2603  Protein of unknown function (DUF2603)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   2.3e-05     0.081      57     113 ..     422     475 ..     401     487 .. 0.87
   2 ?   -3.8   0.2       3.4   1.2e+04      13      30 ..     542     559 ..     536     566 .. 0.50

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.3e-05
     DUF2603  57 eellsklvellkkakeerlelkLEkdilqqiPiDFeDvweValdeikklkkedknlp 113
                 +e+l+ l+e++kk+++++++l   ++il+ + + FeD+ +  ++  k++++++++++
  EFC38450.1 422 NEILTILIEQVKKGHQKNVTL---RQILKTMFVVFEDIATSRMKLFKQSQTSQTSNS 475
                 578999************999...79********************99999987665 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 3.4
     DUF2603  13 nrallkliesedneklLe 30 
                  +a++ +++++dn+  ++
  EFC38450.1 542 IKAIISQKSENDNNVDIQ 559
                 444444444444443333 PP

>> Peptidase_M75  Imelysin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.1   8.4e-05       0.3     109     196 ..     350     476 ..     348     488 .. 0.70
   2 ?   -1.9   0.3      0.49   1.8e+03     239     283 ..     545     592 ..     537     595 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 8.4e-05
                    HCCTTSH...TTTS..HHHHHHHHHHHHHHHHHHHHHHHT........CHHHHHCCH................................SHHHHHH CS
  Peptidase_M75 109 Lfgqdlgagtrpvtdyleylkavaallvsdlqelaaawqpet.....egnyraalta................................sekeale 167
                    Lf++d +++ r+ ++  +++k + + l++++ ++a   ++ +      ++y ++l +                                +++ +l+
     EFC38450.1 350 LFEDD-KKNPRTTEQ-GKAAKNCLSALAQNCVDMAVTFEEISesfslLKKYFSELASnnpitqreefictlgylneiltilieqvkkghQKNVTLR 443
                    89999.555565555.88888888888888888888887665555554445555543566666677777777778888888888888888888*** PP

                    HHHCCHHHHHHHHHHCTTHHHH....TSCHHCH CS
  Peptidase_M75 168 eilngmgslldelaserikvpl....sapdped 196
                    +il++m  +++ +a++r+k       s+ +++ 
     EFC38450.1 444 QILKTMFVVFEDIATSRMKLFKqsqtSQTSNSS 476
                    *******************55566663333333 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.49
                    HHHHHHHHHHHHHHHHHCSSSSGGGGC...T-HHHHHHHHHHHHHHHH CS
  Peptidase_M75 239 laeqldaalaaleaalaaiaapfdqai...gdaegraliqaaidaLse 283
                    + +q  ++ ++++ +++++a++f ++    +d++++al+ a + +L++
     EFC38450.1 545 IISQKSENDNNVDIQMRQYAEKFFTEKmphSDETREALARAFQSELQS 592
                    556666777889999999988888555574455555555555566655 PP

>> DASH_Dad2  DASH complex subunit Dad2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0         3   1.1e+04      49      75 ..      51      77 ..      38      94 .. 0.50
   2 ?   -2.5   0.1         2     7e+03      14      45 ..     159     190 ..     157     198 .. 0.80
   3 ?   -3.5   0.0         4   1.4e+04      47      62 ..     305     320 ..     302     337 .. 0.75
   4 ?   12.5   0.4   4.2e-05      0.15      24      87 ..     421     484 ..     417     498 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3
   DASH_Dad2 49 lanWqnvlraismaslkllqkaeeeae 75
                ++ + ++l+  +    +l ++ ++++e
  EFC38450.1 51 IKRYSEILELHKKILKQLGKRLTSNNE 77
                555555554333333333322222222 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2
   DASH_Dad2  14 LkqlrdlsdslakqleeLeeklstladgteav 45 
                 L++++++s +  + l+ ++   s+ ++gt+ v
  EFC38450.1 159 LEKVKKMSVTSDEDLNMFNSVTSQASKGTSDV 190
                 77888888888888888888888888888765 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 4
   DASH_Dad2  47 sVlanWqnvlraisma 62 
                 +V++n+++ ++  +m+
  EFC38450.1 305 QVMNNYNKAIQYPRMM 320
                 7999999888776665 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 4.2e-05
   DASH_Dad2  24 lakqleeLeeklstladgteavasVlanWqnvlraismaslkllqkaeeeaeeeeedeeeeeee 87 
                 l++ l+ L e++++ ++   +  ++l+    v++ i   ++kl ++++++++++++dee+++++
  EFC38450.1 421 LNEILTILIEQVKKGHQKNVTLRQILKTMFVVFEDIATSRMKLFKQSQTSQTSNSSDEESKSKT 484
                 667788999***********************************99888666666665555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (732 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1648  (0.0919181); expected 358.6 (0.02)
Passed bias filter:                      514  (0.0286686); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.76u 0.32s 00:00:01.08 Elapsed: 00:00:00.50
# Mc/sec: 4441.07
//
Query:       EFC38451.1  [L=272]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       821  (0.0457917); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.55
# Mc/sec: 1500.86
//
Query:       EFC38452.1  [L=626]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.5e-07   29.2   1.0    1.6e-06   28.4   0.1    1.9  2  VWD       von Willebrand factor type D domain
  ------ inclusion threshold ------
        3.2    8.2   8.5       0.68   10.3   1.1    3.7  3  DUF1805   Domain of unknown function (DUF1805)


Domain annotation for each model (and alignments):
>> VWD  von Willebrand factor type D domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.1   1.8e-10   1.6e-06       1     125 [.      51     175 ..      51     182 .. 0.72
   2 ?   -3.7   0.1       1.4   1.3e+04      76      94 ..     279     299 ..     262     319 .. 0.57

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 1.8e-10
         VWD   1 CsvsgdphitTFDgakytfpgnctYvvlaqdcseqpdefsvnvtvkkedagqenvsclksvkvrvg...dveieltrrnkkvlvngqdvsl....plvn 92 
                 C   gdph+ +F g++++  g  +Yv laq++++q   f+v+v   + ++g+ ++ + ++v vr+g   d++ e + +++   + g + sl    +++ 
  EFC38452.1  51 CESVGDPHYLSFTGQRFDHMGLGDYV-LAQSSDNQ---FTVHVR--TSKWGGAAA-VNSNVAVRLGkgeDDTFEYDVEQDVFYLSGVKASLgvnqKVSL 142
                 8889**********************.****9999...566666..555555544.5578888888779555555555533344444444433337788 PP

         VWD  93 agkeveilksgfvvvdvppgveltvdgdgsssl 125
                  ++ v++++ ++ vv+ + g+++t+++  + + 
  EFC38452.1 143 GTGDVQRINTNTAVVSGSNGIKMTMSWYRHAAW 175
                 888999999998888889999999999886555 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.4
         VWD  76 n..kkvlvngqdvslplvnag 94 
                 +  kkv+v +++v  + ++++
  EFC38452.1 279 QniKKVKVAEKKVLKKEIKKK 299
                 334555555555555333332 PP

>> DUF1805  Domain of unknown function (DUF1805)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.63   5.6e+03      38      57 ..     263     282 ..     260     284 .. 0.72
   2 ?   -0.7   0.3      0.21   1.9e+03      32      48 ..     412     428 ..     395     443 .. 0.77
   3 ?   10.3   1.1   7.6e-05      0.68       7      55 ..     568     620 ..     567     622 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.63
                 -SEE-HHHHHTT--TT-BHH CS
     DUF1805  38 vesvteaAeelGikeGmtgk 57 
                 v+++ ++ +++G+k G++ k
  EFC38452.1 263 VKDAIQSGSKIGLKIGQNIK 282
                 66777777888888888766 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.21
                 HHHHSB-SEE-HHHHHT CS
     DUF1805  32 dllaapvesvteaAeel 48 
                 +  ++ +++++++A+++
  EFC38452.1 412 QAAKKAIKEASRKARKI 428
                 55678999999999986 PP

  == domain 3  score: 10.3 bits;  conditional E-value: 7.6e-05
                 HHHHHHTT--EEE-.....-S--SHHHHHHSB-SEE-HHHHHT...T--TT-B CS
     DUF1805   7 vealeklgdlaarvivag.sGVrtledllaapvesvteaAeel...GikeGmt 55 
                 +e++++l+++a++    + + V+ +e+l ++ +++v ++A++l   G+ +G t
  EFC38452.1 568 IEIADRLRKAAEKAAEEAaKRVKMVEELKKKALKDVEKQARKLlngGVSKGKT 620
                 578999999999994444899********************987778888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (626 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4765  (0.265771); expected 358.6 (0.02)
Passed bias filter:                      885  (0.0493614); expected 358.6 (0.02)
Passed Vit filter:                       381  (0.0212505); expected 17.9 (0.001)
Passed Fwd filter:                       141  (0.00786435); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 2.74u 0.42s 00:00:03.16 Elapsed: 00:00:00.72
# Mc/sec: 2634.47
//
Query:       EFC38453.1  [L=100]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0074   16.1   7.8      0.024   14.5   7.8    1.8  1  zf-RING_6      zf-RING of BARD1-type protein
  ------ inclusion threshold ------
      0.014   15.6   9.0      0.034   14.3   8.5    1.9  2  zf-C3HC4_4     zinc finger of C3HC4-type, RING
      0.016   15.1  11.1      0.025   14.4  11.1    1.3  1  zf-C3HC4_2     Zinc finger, C3HC4 type (RING finger)
      0.016   14.4   0.2      0.019   14.2   0.2    1.1  1  Malectin_like  Malectin-like domain
      0.026   14.5   6.3      0.047   13.7   6.1    1.6  1  zf-RING_UBOX   RING-type zinc-finger
      0.095   12.9   8.2       0.16   12.1   8.2    1.4  1  zf-RING_10     zinc RING finger of MSL2
       0.23   11.3  11.8        0.4   10.6  11.8    1.4  1  zf-C3HC4       Zinc finger, C3HC4 type (RING finger)
        0.4   10.7  10.9        1.1    9.3  11.1    1.6  2  zf-RING_5      zinc-RING finger domain
          6    6.6  14.8         15    5.4  14.8    1.7  1  zf-P11         P-11 zinc finger


Domain annotation for each model (and alignments):
>> zf-RING_6  zf-RING of BARD1-type protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   7.8   1.2e-05     0.024       8      36 ..      57      86 ..      53      98 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.2e-05
   zf-RING_6  8 lrcsrctdilrepvclg.gcehifcsncis 36
                ++c  c dil+ep+ l   c h  c+ ci 
  EFC38453.1 57 FKCCWCMDILKEPIQLSsTCSHYGCARCIN 86
                68*************9637*********96 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.8     0.018        36      25      42 .]      45      62 ..      44      62 .. 0.90
   2 ?   14.3   8.5   1.7e-05     0.034       1      29 [.      59      89 ..      59      99 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.018
  zf-C3HC4_4 25 isslqkepdgeqllCplC 42
                i+ + +e +++++ C+ C
  EFC38453.1 45 INMSKNETKSTSFKCCWC 62
                78888999999*****99 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1.7e-05
  zf-C3HC4_4  1 CPiCldYLekPvsle..CGhsfClsCisslq 29
                C  C+d L++P+ l+  C h  C +Ci+ l 
  EFC38453.1 59 CCWCMDILKEPIQLSstCSHYGCARCINLLL 89
                899*********99555**********9775 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4  11.1   1.2e-05     0.025       1      35 [.      58      93 ..      58      98 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.2e-05
  zf-C3HC4_2  1 kCpiCldmlkdpsvvt.pCgHvfCqkCilrsLeekn 35
                kC  C+d lk+p+ +   C H  C+ Ci   L+ ++
  EFC38453.1 58 KCCWCMDILKEPIQLSsTCSHYGCARCINLLLNFEK 93
                6999********998889**********98776544 PP

>> Malectin_like  Malectin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.2   9.3e-06     0.019     212     250 ..      13      53 ..       2      65 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 9.3e-06
  Malectin_like 212 d.sssnnkyepPskvmqtAatpanaseslnltwel.edpta 250
                    + s + ++  pP++++++A++p n+s++ ++t+++ ++ t+
     EFC38453.1  13 NhSRNPSPMVPPTSILKKAVIPPNNSAQNSVTINMsKNETK 53 
                    2355667899****************999999999544444 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   6.1   2.4e-05     0.047       1      30 [.      59      89 ..      59      98 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.4e-05
  zf-RING_UBOX  1 CpIClelftdP.lvl.pCGHtFCreClwelsk 30
                  C  C++ +++P  +  +C+H  C +C+ +l  
    EFC38453.1 59 CCWCMDILKEPiQLSsTCSHYGCARCI-NLLL 89
                  889********733336**********.3333 PP

>> zf-RING_10  zinc RING finger of MSL2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   8.2   7.9e-05      0.16       2      32 ..      58      87 ..      57     100 .] 0.78

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.9e-05
  zf-RING_10  2 sCvvCckLLvdPlepkekeCqHyvCrlCvgk 32
                 C+ C  +L++P++  +++C Hy C +C+  
  EFC38453.1 58 KCCWCMDILKEPIQL-SSTCSHYGCARCINL 87
                69***********97.899*********974 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6  11.8    0.0002       0.4       1      38 [.      59      97 ..      59     100 .] 0.86

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.0002
                -TTT-S--SS-E..E-TTS--B-CHHHHHHHHCTSSB-- CS
    zf-C3HC4  1 CpiCleeakepn.elleCkHsfCskCirkilksrkkvkC 38
                C  C++ +kep   +++C H  C  Ci  +l+++k + C
  EFC38453.1 59 CCWCMDILKEPIqLSSTCSHYGCARCINLLLNFEKLKRC 97
                999*******997899***************98544444 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.9      0.52     1e+03      35      42 ..      55      62 ..      47      64 .. 0.73
   2 ?    9.3  11.1   0.00055       1.1       2      40 ..      59      98 ..      58      99 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.52
   zf-RING_5 35 keavCpiC 42
                 +++C+ C
  EFC38453.1 55 TSFKCCWC 62
                57899999 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00055
   zf-RING_5  2 CnkCfeklskeekfyltsCgHifCekClkkll..ekeavCp 40
                C  C++ l ke      +C+H+ C +C++ ll  ek ++C+
  EFC38453.1 59 CCWCMDIL-KEPIQLSSTCSHYGCARCINLLLnfEKLKRCC 98
                77788888.777778899************99995555554 PP

>> zf-P11  P-11 zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4  14.8    0.0074        15       4      41 ..      56      98 ..      54     100 .] 0.70

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0074
                SBTTTSS--..S...SEEE-SSSEEEHHHHHHHHHHSSBETTT CS
      zf-P11  4 sCksCWfkd..k...sLveCsdHYLClrClqllLsvserCpiC 41
                s k+CW  d  k   +L     HY C rC +llL   ++   C
  EFC38453.1 56 SFKCCWCMDilKepiQLSSTCSHYGCARCINLLLNFEKLKRCC 98
                569***8764441224555567************987665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (100 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       908  (0.0506442); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.53
# Mc/sec: 569.39
//
Query:       EFC38454.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.9e-11   43.9  23.2    1.4e-08   34.7   5.5    2.4  2  zf-B_box    B-box zinc finger
  ------ inclusion threshold ------
        8.1    6.3  10.2    3.5e+02    1.1  10.2    2.8  1  zf-C2H2_11  zinc-finger C2H2-type


Domain annotation for each model (and alignments):
>> zf-B_box  B-box zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   9.8   2.5e-06     0.022       5      37 ..       1      38 [.       1      43 [. 0.86
   2 !   34.7   5.5   1.6e-12   1.4e-08       3      42 .]      52      91 ..      50      91 .. 0.95

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.5e-06
    zf-B_box  5 kCpeHknkpatlfCedCqqplCeeCstgeHr.....gH 37
                +C ++++  at  Ce+C+  lC eC  ++H       H
  EFC38454.1  1 MCANCETTLATCQCETCKFILCGECFASIHDqkllsSH 38
                5************************9999976666556 PP

  == domain 2  score: 34.7 bits;  conditional E-value: 1.6e-12
    zf-B_box  3 etkCpeHknkpatlfCedCqqplCeeC.stgeHrgHevvpl 42
                + kC++H+ k + lfC ++++ +C+ C  +++H++H+++p+
  EFC38454.1 52 NEKCMKHG-KDLDLFCMNDNEKVCSLCaISETHKNHQCIPV 91
                579*****.*****************************996 PP

>> zf-C2H2_11  zinc-finger C2H2-type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1  10.2     0.039   3.5e+02       3      17 ..      10      29 ..       8      31 .. 0.69

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.039
  zf-C2H2_11  3 stcqC.....leCGlcftSq 17
                +tcqC      +CG cf+S 
  EFC38454.1 10 ATCQCetckfILCGECFASI 29
                68888333335678899995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1500  (0.0836633); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.36s 00:00:01.00 Elapsed: 00:00:00.57
# Mc/sec: 1693.01
//
Query:       EFC38455.1  [L=1089]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-43  148.9   1.2    1.1e-43  148.9   1.2    2.2  2  E1-E2_ATPase  E1-E2 ATPase
    6.8e-42  144.1   0.6    1.1e-41  143.4   0.6    1.4  1  Hydrolase     haloacid dehalogenase-like hydrolase
      7e-09   36.0   0.4    6.5e-08   32.9   0.1    2.4  2  HMA           Heavy-metal-associated domain
    6.1e-05   23.5   0.0    0.00019   21.9   0.0    1.8  1  HAD           haloacid dehalogenase-like hydrolase
      0.001   18.8  13.4      0.014   15.1   0.1    3.9  4  Hydrolase_3   haloacid dehalogenase-like hydrolase
  ------ inclusion threshold ------
      0.014   15.5   0.1      0.014   15.5   0.1    2.6  3  HAD_2         Haloacid dehalogenase-like hydrolase
        9.6    4.6  20.1         15    4.0  20.1    1.2  1  Macoilin      Macoilin family


Domain annotation for each model (and alignments):
>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.5      0.51   1.3e+03     114     156 ..     471     513 ..     459     517 .. 0.72
   2 !  148.9   1.2   4.3e-47   1.1e-43      14     177 ..     570     742 ..     557     745 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.51
                   HHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHH CS
  E1-E2_ATPase 114 kldklgkvlvpvvlliallvflialllgkslaeallralallv 156
                   ++d l+   ++++ + +l+  +ia++++   aea++++ all+
    EFC38455.1 471 NMDTLVMLSTTTAYVYSLVSTIIAMFVETYKAEAFFETSALLL 513
                   5677777777777777777778887877777777777766665 PP

  == domain 2  score: 148.9 bits;  conditional E-value: 4.3e-47
                   S-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-SEEE-TTTS---S-EE-G-TTEE-TT-EEEE-EEEEEEEE-TTTSTTTTTSTTS--------H CS
  E1-E2_ATPase  14 teeeidakelvpGDivllkagdrvpaDgrivegsaevdesaLTGEslpvekekgdmvfsGtvvvsgeakavVtatgedtelgkiarlveeakskktp 110
                   +eeeid++ ++ GDi+++ +g+++p+Dg+++ g++++des++ GEs pv k+ gd v+++t++  g++ ++Vt+t ++++l+ i +l+ e++++k p
    EFC38455.1 570 EEEEIDTDLVQRGDILKCLPGSKIPTDGVVFYGTTSIDESMISGESIPVNKDVGDFVYGSTINQFGTIYIRVTKTSSENTLSSIDKLIHESQNAKVP 666
                   7899********************************************************************************************* PP

                   HHHHHHHHHHHHHHHHHHHHHHHHHS-ST......TTSSTT.......HHHHHHHHHHHHHS-TTHHHHHHHHHHHHHHH CS
  E1-E2_ATPase 111 lqkkldklgkvlvpvvlliallvfliall......lgksla.......eallralallvaaiPcaLplavplalalgarr 177
                   +q+++d++++v+vpv++ i+ll+f+i+++      l            +al ++la+lv+++Pca+ la+p+a+++g+++
    EFC38455.1 667 IQRIADNVSAVFVPVIIGISLLAFIIWISlcyagvL----EtdlhpitFALQFSLAILVISCPCAISLAAPTAVMVGIAK 742
                   ****************************96655542....14555777*****************************987 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.4   0.6   4.5e-45   1.1e-41       1     210 []     762     986 ..     762     986 .. 0.93

  Alignments for each domain:
  == domain 1  score: 143.4 bits;  conditional E-value: 4.5e-45
                 SSEEEEESBTTTBCHHHHHHHHHHHH..CHHHHHHHHHH......HHCHHHHHHHHHHHHHHHHH...HHHHHETTTE........HHHHTHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxx...xxxxxxxxxx........xxxxxxxxxxxxx RF
   Hydrolase   1 iktvvfDkdGTLttgepsvedvivsa..alalaaaletg......sehpigkalvaaakarsgal...tgfatfigrg........ayaigkpewltal 80 
                 ++tv+fDk+GTLt+g+p+v+dv+     +l+  +a+         seh igka+    +++++a+    ++++++g+g        ++  g+  w++++
  EFC38455.1 762 VNTVIFDKTGTLTNGKPVVTDVLLFEgdDLKQFKAI--IgsaelgSEHVIGKAISTHVEKEGIAIeqpVDYQAVPGKGlkctvygkQVIAGNCTWMKDN 858
                 69********************99996633333333..3336788*********999999977776679****************************** PP

                 ..HCHHHHHHHHHHHHHHCHHHHHH..TTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHHTTGGGESEEEEHHCES.STTT CS
                 ..xxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx RF
   Hydrolase  81 ..dippdlgaaigsaqsqgrtvall..qaralavftiadplkvkpeaaeavasLkaagievvlltgdnpetaeraanqlGddyfdaviasdiet.vakp 174
                   +i++  +++i +++ qg+t + +  ++ ++++++++d+  +k e + ++ +Lk++++e+++++gdn+ t + +anqlG           ie   a +
  EFC38455.1 859 siEISETQQEQILTLENQGKTIVHVaiDGSLHGIVALSDT--LKVESKRVIDELKKKNVEIWVVSGDNQVTTRYIANQLG-----------IENvMANV 944
                 *************************99*************..**************************************...........7777**** PP

                 SHHHHHHHHHHHT......STGGGEEEEESSHHHHHHHHHTT CS
                 xxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 175 spegkvaaireLq......gkpeevamVGDgvnDaaalaaAg 210
                 +p  k++++ eLq      gk++ vam+GDg+nD++ la+A+
  EFC38455.1 945 LPAYKREKVLELQqgktsnGKKRVVAMIGDGINDSPSLAQAD 986
                 ************999999999********************8 PP

>> HMA  Heavy-metal-associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.9   0.1   2.6e-11   6.5e-08       3      61 ..     229     287 ..     227     288 .. 0.93
   2 ?    0.4   0.0      0.37   9.4e+02      18      57 ..     325     364 ..     320     367 .. 0.85

  Alignments for each domain:
  == domain 1  score: 32.9 bits;  conditional E-value: 2.6e-11
         HMA   3 rvsgmhCagCaakvekvLselpgVesvkvdlatktvtVegdaestklrkiieaiekagy 61 
                  v ++hCa Ca+ ve vL + +g+ ++ v+  t+++ V++d+  +    i+++i+++g+
  EFC38455.1 229 TVRNLHCADCANMVEGVLIKKNGILNARVNSMTDSAHVVYDELIIQETLIVKSIQDLGF 287
                 799****************************************966566******9998 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.37
         HMA  18 kvLselpgVesvkvdlatktvtVegdaestklrkiieaie 57 
                 k++++ +g+     d  +  ++V ++++ t  r+i++ ie
  EFC38455.1 325 KSIEKGDGIIHTAYDTSSCLLQVAYNPDITGTRDIKKMIE 364
                 567777888888888888899999****9999***99998 PP

>> HAD  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.0   7.3e-08   0.00019      89     187 ..     902     982 ..     890     983 .. 0.83

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 7.3e-08
         HAD  89 galellaahraaGdrvvvvSgglrplvepllaelgadevlatelevddrltgelglegkpvrgegkvaalrewlaaegegidleevvayGDspsDlpll 187
                 + ++++++ ++++++++vvSg ++  ++ ++++lg+++v+a+      +          p ++++kv +l++  +++++g ++  v  +GD+++D p l
  EFC38455.1 902 ESKRVIDELKKKNVEIWVVSGDNQVTTRYIANQLGIENVMAN------V---------LPAYKREKVLELQQ--GKTSNGKKRV-VAMIGDGINDSPSL 982
                 5567888899*************************8888888......2.........44568889999999..9999888763.5666******8865 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   1.8      0.31   7.9e+02      81     131 ..      92     141 ..      52     189 .. 0.56
   2 ?   -2.9   0.2       1.7   4.4e+03      84      92 ..     359     367 ..     298     400 .. 0.48
   3 !   10.2   0.0   0.00018      0.45      14      58 ..     897     941 ..     883     945 .. 0.85
   4 !   15.1   0.1   5.5e-06     0.014     200     245 ..     963    1008 ..     946    1017 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.31
                  HHHHHHHHHHHHHTTCEEEEEESSEEEESTT.THHHHHHHHHCHCTCEEEE CS
  Hydrolase_3  81 kedvkeiikllkennveillytedkvyvlnkeksekkkkeeektkkkkeei 131
                  +++v++ +k+ k    + l+y+++k+ +++  ++ +k+++e++++++ ++ 
   EFC38455.1  92 HSAVNSTHKHSKRGTKSKLMYGKKKIKISQL-QHLTKQHDEHHHEEETTSE 141
                  3444444444444445555555555555555.2222211111111111111 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.7
                  HHHHHHHHH CS
  Hydrolase_3  84 vkeiikllk 92 
                  +k++i+++ 
   EFC38455.1 359 IKKMIETID 367
                  222222222 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00018
                  S---HHHHHHHHHHHHTTSEEEEE-SS-HHHHHHHHHHCCCCSEE CS
  Hydrolase_3  14 kkisektkeaikklkekgikvviATGRslravlpvleelgldlpv 58 
                   +++ ++k++i +lk+k++++ + +G + +++++++++lg+++ +
   EFC38455.1 897 DTLKVESKRVIDELKKKNVEIWVVSGDNQVTTRYIANQLGIENVM 941
                  5577799**********************************9665 PP

  == domain 4  score: 15.1 bits;  conditional E-value: 5.5e-06
                   T--GGGEEEEESSGGGHHHHHHSSEEEEETTS-HHHHHHSSEEE-- CS
  Hydrolase_3  200 nisleeviafGDgeNDieMLeaaglgvAmgnaseevkkaAdyvtks 245 
                   n ++  v+ +GDg ND + L +a++g+A+g +s+ + + Ad +  +
   EFC38455.1  963 NGKKRVVAMIGDGINDSPSLAQADVGFAIGCGSDIALETADIILVK 1008
                   556667899********************************98765 PP

>> HAD_2  Haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.5   1.1         7   1.8e+04      40      77 ..     103     137 ..      86     145 .. 0.55
   2 ?   -0.6   0.2      0.46   1.2e+03      76     118 ..     351     392 ..     272     396 .. 0.73
   3 ?   15.5   0.1   5.3e-06     0.014      83     173 ..     902     987 ..     895     991 .. 0.84

  Alignments for each domain:
  == domain 1  score: -4.5 bits;  conditional E-value: 7
       HAD_2  40 liglslrellrklgeseeeeekieellrkyneekkkke 77 
                 + g +++ ++ k +++      ++ l +++ e+++++e
  EFC38455.1 103 KRGTKSKLMYGKKKIKIS---QLQHLTKQHDEHHHEEE 137
                 444444444444333322...67777777777777744 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.46
       HAD_2  76 kevkpydgvkelLeeLkeagyklgivTsksreaveekleqlgi 118
                   ++   ++k+++e++ +  +   i++ +++++++++ ++++i
  EFC38455.1 351 PDITGTRDIKKMIETI-DSSHMFTIMSGSKANEITDQNNKNEI 392
                 4566778999999999.88889999999988888888777766 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 5.3e-06
       HAD_2  83 gvkelLeeLkeagyklgivTsksreaveekleqlgiesyFdvivtsedvekkKPdpeviekaleklklkkeeviyvGDsptDieaakkagi 173
                 + k +++eLk++++++ +v+  ++ +++   +qlgie+++  ++ + + ek      + ++  +  + kk  v ++GD ++D  +  +a +
  EFC38455.1 902 ESKRVIDELKKKNVEIWVVSGDNQVTTRYIANQLGIENVMANVLPAYKREKV-----LELQQGKTSNGKKRVVAMIGDGINDSPSLAQADV 987
                 57899**************************************999876666.....4445556668899999999**9999877666655 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0  20.1    0.0058        15     235     389 ..      53     222 ..       8     324 .. 0.49

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.0058
    Macoilin 235 sknnhslnkkdsslklpeleyrekkksakssrsdskkkhehn....esvdsklqekeym.enkskskrlsksessgsesellveesvkskssssssssn 328
                 +k+++ + ++ +++  ++   +++++s++   s+++++heh+    +   +k+++   + +    +k+++ s  + ++ + +++e+ +++++ +s+++n
  EFC38455.1  53 EKKENITVDRMETKACSKACCSSSSSSKAGC-SEEEEQHEHSavnsT---HKHSKRGTKsKLMYGKKKIKIS--QLQHLTKQHDEHHHEEET-TSETTN 144
                 2222222222333333333333333333333.334444444433221...2222221110112222222222..222222222222222221.222222 PP

    Macoilin 329 knskkasagsagssnssskkhsessksvtsss..ssknskkq...............klpaGkssaalkdaaenslpn 389
                   +k++s++  + ++ s +k++e ++ + s    s + skk                +  +  ++++++ + +n lpn
  EFC38455.1 145 ICEKSSSSNCCSYGSCSKEKQKEPNNAIVSDCcsSGSCSKKSnvpvekkstctsgccQSVSTSTESRTELKLDNLLPN 222
                 333333444444444444444444444333321233333444111111111111111221223333444445555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1089 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1560  (0.0870099); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.89u 0.33s 00:00:01.22 Elapsed: 00:00:00.51
# Mc/sec: 6445.42
//
Query:       EFC38456.1  [L=389]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.1e-67  225.2  21.4    8.9e-67  224.9  21.4    1.1  1  Form_Nir_trans  Formate/nitrite transporter


Domain annotation for each model (and alignments):
>> Form_Nir_trans  Formate/nitrite transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  224.9  21.4     5e-71   8.9e-67       2     236 .]      88     341 ..      87     341 .. 0.95

  Alignments for each domain:
  == domain 1  score: 224.9 bits;  conditional E-value: 5e-71
                     HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHCCT...TCHHHHHHHHHCCCHHHHHHHHHT---CCCCCCHHHHHHCTTS. CS
  Form_Nir_trans   2 ivekvvaagvkkaklsldklfllgilAGafigfgvllalvvaaalaes...npglakllgglvFpvGlilvvllgaeLfTgntllltlavlkkk. 92 
                     ++e++   g +k kl++d++++l+++AG+fig+++++a+++++++++    npgl+kll+g+vFp+Glil+ ++g+eLfTgn+l+l++a++++k 
      EFC38456.1  88 VLERMKVDGIRKSKLTVDQIIILSLFAGLFIGLACAMAILIGGNVPDLeekNPGLQKLLSGAVFPIGLILIAMTGSELFTGNVLVLLVALFSRKw 182
                     57899999*************************************88899*****************************************9886 PP

                     ......SSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTG.....GHHHHHHHHHCCCSS-HHHHHHHHHHHHHHHHHHHHHHCC-SSHHHHHHH CS
  Form_Nir_trans  93 ......vslkkllknwlvvllgNliGsllvalllvvlsgl.....laekllsiaeaklslsfleaflrGilCNwlVclavwlalaakdvigkila 176
                           ++++++ kn++v++l+N++G++l+a+++v+l +      + +++ +++ ak++++f++++l +i+CN+lV++ v+++ aa+++ gk+l+
      EFC38456.1 183 rakkflLQYTQFSKNLFVSYLFNCLGAFLFAYFFVYLPQPccsayWIKYIQNMSVAKTTKTFGNLVLLAIICNMLVTVSVFCCNAATTLGGKFLG 277
                     7777777889999**********************99888655545************************************************* PP

                     HHHHHHHHHHCT---HHHHHHHHHHHHHH....SHHHHHHHCHHHHHHHHHHHHHCCHHHHHHH CS
  Form_Nir_trans 177 iflpifafvasgfeHsvanmfliplglll....tvadfilknlipvtlGNivGGallvgllyly 236
                     i++p+++fv++gfeHs+an f+iplg+l+    t +df++ nl+pvt+GNi+GGa++ g+l++y
      EFC38456.1 278 IWFPLMTFVCLGFEHSIANAFYIPLGMLYganvTGYDFLIGNLLPVTIGNIIGGAIINGCLLYY 341
                     ***************************99998899*************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1398  (0.0779742); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.36s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 2123.18
//
Query:       EFC38457.1  [L=506]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-11   44.8   0.0    3.6e-11   43.8   0.0    1.5  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
    2.1e-05   23.8   0.0    5.7e-05   22.4   0.0    1.7  1  Pox_C4_C10      Poxvirus C4/C10 protein
     0.0071   16.7   1.7      0.024   15.0   1.2    2.1  1  PRANC           PRANC domain
  ------ inclusion threshold ------
       0.01   15.7   0.8      0.021   14.7   0.8    1.6  1  F-box           F-box domain
      0.015   15.2   0.3      0.044   13.7   0.3    1.9  1  F-box-like      F-box-like
      0.074   12.9   0.0       0.14   12.0   0.0    1.5  1  F-box_4         F-box


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.8   0.0   1.2e-14   3.6e-11       2      91 ..     179     273 ..     178     277 .. 0.89

  Alignments for each domain:
  == domain 1  score: 43.8 bits;  conditional E-value: 1.2e-14
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--EEE....................---TT-EEEEE-..B-TEEE--B.-SS CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekeseeGGelelyekdk..........eavkikpkkgrlvlFesdellpHevlpvtkgg 86 
                      +++y++g+++kpH+D    ++++++ ++t+++yLn  + + GGe +++++ +          +  +i+pk g++ +F+ d    H+++ vt+g 
      EFC38457.1 179 RLSKYEPGNYFKPHTDGQFVRNDDERSIYTLIIYLN--DGFVGGETKFMRRVDplaenemkfkNLCEISPKMGSASVFNHDLY--HQGCLVTEG- 268
                     6899************9888888899*********8..67*****999777778999999998899999***********877..******875. PP

                     -EEEE CS
  2OG-FeII_Oxy_3  87 eRlsl 91 
                      +++l
      EFC38457.1 269 VKYIL 273
                     99987 PP

>> Pox_C4_C10  Poxvirus C4/C10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.0   1.9e-08   5.7e-05      62     167 ..     159     290 ..      97     304 .. 0.73

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 1.9e-08
  Pox_C4_C10  62 s...........evevenkvtlvkyekgdyfkrtrn.lstklskntveyylvlyLekpeeGGetkiy..ikptgs..........i..ksseDilfdks 134
                 +            ++v++ + l kye+g+yfk +++ + +++ ++   y+l++yL+    GGetk++  ++p  +          i  k+ +  +f+  
  EFC38457.1 159 KpygldsegywiPISVNECMRLSKYEPGNYFKPHTDgQFVRNDDERSIYTLIIYLNDGFVGGETKFMrrVDPLAEnemkfknlceIspKMGSASVFNHD 257
                 055555555555689999999***************988888889999*****************9855565544454555554432234567899999 PP

  Pox_C4_C10 135 lefeskvVesgrklvAlldvllkekdvittiey 167
                 l+++   V +g+k++   ++++k  d+  ++  
  EFC38457.1 258 LYHQGCLVTEGVKYILRTEIMFKRIDSAEQLVT 290
                 999999999999999999999986555555444 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   1.2     8e-06     0.024      62      96 ..     353     388 ..     329     389 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 8e-06
       PRANC  62 lnnicsk.kslWnlLPiEIkykIleyLndkdLknll 96 
                 ln    + ks++++LP EI  +I+++Lnd ++++l+
  EFC38457.1 353 LNAENYSmKSSISRLPDEIISHICKFLNDWEICKLI 388
                 333333458************************997 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.8     7e-06     0.021       2      26 ..     363     387 ..     362     389 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 7e-06
                 HHHHS-HHHHHHHHHTS-HHHHHHH CS
       F-box   2 tlsrLPsevlrhILerLplsdllal 26 
                 ++srLP+e++ hI ++L+  +++ l
  EFC38457.1 363 SISRLPDEIISHICKFLNDWEICKL 387
                 89****************9999976 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.3   1.5e-05     0.044       1      42 [.     364     405 ..     364     411 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.5e-05
  F-box-like   1 isrLPdEiLlqIFsyLppsdLlrl.alVCrrWrrvaldtplLW 42 
                 isrLPdEi+++I  +L++ +++ l     r+++++ ++   LW
  EFC38457.1 364 ISRLPDEIISHICKFLNDWEICKLiLPLDRYFNDIGRNS-PLW 405
                 689*************99999986355556666665555.555 PP

>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   4.7e-05      0.14       3      30 ..     362     389 ..     360     424 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.7e-05
     F-box_4   3 dsLssLPlevlqhiaslLDsfsLsqLsl 30 
                 +s+s+LP e++ hi+++L +  +++L l
  EFC38457.1 362 SSISRLPDEIISHICKFLNDWEICKLIL 389
                 6799********************9965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (506 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       833  (0.046461); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 3143.50
//
Query:       EFC38458.1  [L=735]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0032   17.7   0.1      0.012   15.8   0.1    1.9  2  Kelch_6     Kelch motif
  ------ inclusion threshold ------
        2.1    8.5   5.6        4.5    7.4   0.6    2.4  2  Mut7-C      Mut7-C RNAse domain


Domain annotation for each model (and alignments):
>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.1   1.4e-06     0.012      12      41 ..     551     573 ..     538     582 .. 0.80
   2 ?   -3.3   0.0       1.5   1.3e+04      11      22 ..     689     700 ..     688     709 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.4e-06
     Kelch_6  12 gkiYifGGytdsspylnkvwvydpetksWe 41 
                  +iY++GG+++       +w++d++tk+W 
  EFC38458.1 551 QFIYLLGGSGN-------LWKFDLKTKTWA 573
                 59*******76.......9**********6 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.5
     Kelch_6  11 ggkiYifGGytd 22 
                 +++i ++G +  
  EFC38458.1 689 NNTIIVIGSSEL 700
                 789999998865 PP

>> Mut7-C  Mut7-C RNAse domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.6    0.0005       4.5      32      75 ..      37      80 ..      23      94 .. 0.80
   2 ?    3.0   0.5     0.011        99      30      87 ..     259     317 ..     220     323 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0005
      Mut7-C 32 eellalaakekrillTrdreLlkraklkkgvlltsrdveeqlre 75
                +e  +   +e+ i+l  d +Ll+++++++++  ++++ ee l++
  EFC38458.1 37 AEQSSSEDEEEEIMLAEDDDLLTQQNNHHQHHPNEEEEEEDLNN 80
                444455568899********************999999998876 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.011
      Mut7-C  30 edeellalaakekrillTrdreLlkraklkkg.vlltsrdveeqlreviarlglklslk 87 
                 e+++ +++a ++  +l+  d +++ ++++ ++  l+++++++ + +++i+ ++l+ +l+
  EFC38458.1 259 ENRQTISIADEQMNVLVMEDDQIVVNQEVIEKpSLIQQQETQPNNTDIISSINLDEDLD 317
                 7889999****************999999888899999999999999999999988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (735 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1688  (0.0941491); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.84u 0.37s 00:00:01.21 Elapsed: 00:00:00.54
# Mc/sec: 4084.74
//
Query:       EFC38459.1  [L=127]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (127 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       681  (0.0379832); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 765.08
//
Query:       EFC38460.1  [L=396]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.4e-21   76.3   1.9    6.8e-21   75.7   1.9    1.3  1  Metallophos    Calcineurin-like phosphoesterase
    4.8e-05   23.6   0.1    0.00049   20.3   0.1    2.1  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d
     0.0011   18.1   1.9       0.42    9.6   0.3    2.2  2  PhoD           PhoD-like phosphatase


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.7   1.9   1.1e-24   6.8e-21       2     203 ..     104     318 ..     103     319 .. 0.71

  Alignments for each domain:
  == domain 1  score: 75.7 bits;  conditional E-value: 1.1e-24
                  EEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSS........HHHHHHHHHHHHHHHHTSEEEEEC-TTSCHHHHHHHHHHHHHHH CS
  Metallophos   2 rilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrg........dlekellellaalvkypipvylllGNHegfeeellnkygylgif 91 
                  ++lvigD +  + ++q   ++ + + ++++ ++d+v+ +GD+++ +        ++ +++++ ++++  ++  +y++lGNH+ ++++++ +   ++  
   EFC38460.1 104 HFLVIGDFG-RENDAQRKVANSMGEYCKENDGCDFVVGVGDNIYQSgvesiydeQFKTKFEDIYNHKALEDLDFYMILGNHD-YRNDVKAQIL-YTQL 198
                  79******9.333333333333335558889******99**999995666665555665666666666669999********.6666666644.4556 PP

                  HHHHEHHHCEEETSEEEEEETTE.EEEEEEESECEEE...THHHHHHHHHHHSCHHHHCC...HHHHHH..HHHHTTCSEEEEEESSESSCSSSCSCC CS
  Metallophos  92 sepwrsdaevfnnlplaslgsgs.lkvlllhGgspel...lvsldklgslnleleapepg...dewlkd..lekrekadwvivlgHsplyrgsgylfg 180
                  s+ w++  ++f  ++  s  +g+ l++l+ + ++ ++   l+ l++ + +n +           ewlk    + +++++w+iv gHsp+y +++++++
   EFC38460.1 199 SKRWKML-DFFYEINKKSRLGGFdLNLLFTDTNPFHFlffLDPLTNKTVINEQAKR---IpeqMEWLKSklRKPKGDDQWTIVAGHSPVY-SASQHYD 291
                  9999997.555566666666666777777777766664554444444444444433...3555*******9999999*************.6666666 PP

                  HHHHH....HHHHHTTESEEEEESSSS CS
  Metallophos 181 deale....dllkkygvdlvisGHtHv 203
                  ++ l     +l+++y+v l+++GH+H+
   EFC38460.1 292 SQPLIqnfePLFREYRVPLYLCGHDHQ 318
                  666666999*****************7 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.1   8.3e-08   0.00049       3     149 ..     105     345 ..     103     353 .. 0.68

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 8.3e-08
  Metallophos_2   3 laiiSDlHsnldaleav.......lealkevgvdaiihaGD..............leeeepevleellela..pvlaVrGNnD............. 62 
                    +++i D+ ++ da+++v        ++ +++  d ++ +GD              + ++++e +++ ++l+  +++++ GN+D             
     EFC38460.1 105 FLVIGDFGRENDAQRKVansmgeyCKENDGC--DFVVGVGDniyqsgvesiydeqF-KTKFEDIYNHKALEdlDFYMILGNHDyrndvkaqilytq 197
                    7889999988888888866665544444555..********776666665432221.3333444444444477*********************** PP

  Metallophos_2  63 .............................................eev.veedvlreaaelgtdlpeeaelelagekvlliHgdpl.......... 102
                                                                 +   v+++ +++  e ++ l+++ +   ++++  ++ g+ +          
     EFC38460.1 198 lskrwkmldffyeinkksrlggfdlnllftdtnpfhflffldpltN-KtVINEQAKRIPEQMEWLKSKLRKPKGDDQWTIVAGHSPvysasqhyds 292
                    ******9999999999999999999999999999999999887752.2344444444444445554333333333333333333333466555556 PP

  Metallophos_2 103 .gvkdalaellkeaeegsdvvvcGHtHvpeveke.......ggvlvvnPGsvgep 149
                      + +++++l++e  +++ +++cGH H+ ++ +        +++ ++  G++g+ 
     EFC38460.1 293 qPLIQNFEPLFRE--YRVPLYLCGHDHQLGWMANreiinsrEQTQYIISGAAGGS 345
                    6888899999998..9999**********77666223333346677777777665 PP

>> PhoD  PhoD-like phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.6   0.3     7e-05      0.42      17      67 ..     125     177 ..     116     201 .. 0.59
   2 !    7.8   0.1   0.00024       1.4     197     250 ..     256     325 ..     243     339 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 7e-05
        PhoD  17 yrelaeee.dlDlvlhlGDyiYeygpgeyase.aaelgreveppkeivtladY 67 
                 + e ++e+   D+v+ +GD iY+ g +++  e  +++ ++  ++k++++l+ Y
  EFC38460.1 125 MGEYCKENdGCDFVVGVGDNIYQSGVESIYDEqFKTKFEDIYNHKALEDLDFY 177
                 5556665449**************95444433133333333333333333333 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00024
        PhoD 197 eQeqwLkaeLkasrar..Wkvlaqqvlmskvdld..aelaega................lpvnlDawdGypaeR 250
                 eQ++wLk++L++ +    W ++a + ++ + + +  ++                          D   G  a+R
  EFC38460.1 256 EQMEWLKSKLRKPKGDdqWTIVAGHSPVYSASQHydSQ----PliqnfeplfreyrvplYLCGHDHQLGWMANR 325
                 8**********9887777*****999887776221122....12333555555555555445555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (396 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       729  (0.0406604); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2285.75
//
Query:       EFC38461.1  [L=757]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-06   27.5   2.4      0.016   15.0   0.1    2.8  2  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.025   14.8   0.5         30    4.9   0.0    3.8  3  DUF3870   Domain of unknown function (DUF3870)
       0.38   11.4   1.0         39    5.0   0.0    3.5  3  RCC1      Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.2   2.8e-05      0.17       9      23 ..     111     125 ..     110     125 .. 0.97
   2 !   15.0   0.1   2.7e-06     0.016       1      30 []     253     282 ..     253     282 .. 0.97

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.8e-05
      RCC1_2   9 yHscaLtedGeVlcW 23 
                 +H+++Lt++G+V++W
  EFC38461.1 111 SHALFLTREGHVYSW 125
                 6************** PP

  == domain 2  score: 15.0 bits;  conditional E-value: 2.7e-06
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++s+ ++H ++ t+ +++l+ G+N +GQ
  EFC38461.1 253 IVDMSCSNNHMIIATNQNRLLAMGHNISGQ 282
                 799***********************9998 PP

>> DUF3870  Domain of unknown function (DUF3870)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0     0.052   3.1e+02      25      59 ..     245     279 ..     233     329 .. 0.77
   2 ?    3.6   0.0     0.014        81      49      90 ..     444     485 ..     430     489 .. 0.85
   3 ?    4.9   0.0    0.0051        30       8      42 ..     535     569 ..     532     573 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.052
     DUF3870  25 lvvdkktgeivdadctltlelteeFvrsll.vgksl 59 
                 + v ++ ++ivd++c++   ++    ++ll +g+++
  EFC38461.1 245 FNV-SNGEKIVDMSCSNNHMIIATNQNRLLaMGHNI 279
                 444.34578999999886666554444444246665 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.014
     DUF3870  49 FvrsllvgkslledieeieeeikerYfgssqka.liaalkdal 90 
                 Fv+++   +++l+  e+i + ++ +++ +s+++ l++a+k + 
  EFC38461.1 444 FVEQI-SLENVLDSLEQISKYLSMKVLTNSKTSvLMVAVKACF 485
                 77777.66788888*****************983578999886 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.0051
     DUF3870   8 lpsenaitelYktffislvvdkktgeivdadctlt 42 
                 +ps + i++lY+   +s++vd   ++iv++ ++ +
  EFC38461.1 535 TPSAEVINNLYNKGELSFIVDHLGERIVKVHKSII 569
                 789999***********************998866 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.43   2.6e+03       1       7 [.     119     125 ..     119     125 .. 0.94
   2 ?    2.5   0.1     0.039   2.3e+02      32      47 ..     248     263 ..     243     265 .. 0.80
   3 ?    5.0   0.0    0.0066        39       3      20 ..     271     288 ..     269     304 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.43
                 TTEEEEE CS
        RCC1   1 dGrVysW 7  
                 +G+VysW
  EFC38461.1 119 EGHVYSW 125
                 7****** PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.039
                 GTTS-EEEEEEETTEE CS
        RCC1  32 lsgnrvvkvacGddht 47 
                 ++g+++v+++c ++h 
  EFC38461.1 248 SNGEKIVDMSCSNNHM 263
                 5666***********5 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0066
                 EEEEEE--GGGTTSSSS- CS
        RCC1   3 rVysWGrndyGqLGlgtt 20 
                 r+++ G n  GqLG ++ 
  EFC38461.1 271 RLLAMGHNISGQLGAKHF 288
                 899***********9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (757 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       754  (0.0420548); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.71u 0.28s 00:00:00.99 Elapsed: 00:00:00.48
# Mc/sec: 4760.15
//
Query:       EFC38462.1  [L=1069]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   1.4e-106  356.9   0.1   3.7e-106  355.5   0.1    1.7  1  RNA_pol_Rpb2_6  RNA polymerase Rpb2, domain 6
    9.4e-23   80.2   0.1    2.1e-22   79.1   0.1    1.6  1  RNA_pol_Rpb2_3  RNA polymerase Rpb2, domain 3
    7.5e-21   74.3   0.1      2e-20   72.9   0.1    1.8  1  RNA_pol_Rpb2_7  RNA polymerase Rpb2, domain 7
    3.8e-13   49.4   0.0    4.7e-13   49.1   0.0    1.3  1  RNA_pol_Rpb2_1  RNA polymerase beta subunit
    3.5e-12   46.1   0.0    8.6e-12   44.9   0.0    1.7  1  RNA_pol_Rpa2_4  RNA polymerase I, Rpa2 specific domain
    0.00033   20.3   0.1     0.0036   17.0   0.1    2.5  2  RNA_pol_Rpb2_2  RNA polymerase Rpb2, domain 2
     0.0024   18.1   0.0      0.007   16.6   0.0    1.8  1  RNA_pol_Rpb2_4  RNA polymerase Rpb2, domain 4
  ------ inclusion threshold ------
       0.18   12.7   0.0        0.8   10.6   0.0    2.1  2  Ribosomal_L17   Ribosomal protein L17


Domain annotation for each model (and alignments):
>> RNA_pol_Rpb2_6  RNA polymerase Rpb2, domain 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  355.5   0.1  1.7e-109  3.7e-106       3     390 .]     587     950 ..     585     950 .. 0.90

  Alignments for each domain:
  == domain 1  score: 355.5 bits;  conditional E-value: 1.7e-109
                     HT-SS-TTB-HHHHHHHHHHGGGB-S---TTTTT---SSEEEESS----SSB-S.TTTTTS........GGGS-SEEEEEBBBS--TTTTTTT-E CS
  RNA_pol_Rpb2_6   3 klapvvehvqspriiiqaamekqalgiyslnkfkrsnqktyllcinqkPlvktgdkveagqvldgpatekgelalGqnavVAvmsyeGYniEDai 97 
                     +l+p+++ +qspr i+q++m+kq++  + ++  +r+++k++ + ++qkPl +t+ + + +         ++e+ +G navVAv+sy+GY++EDa+
      EFC38462.1 587 NLTPFCNFNQSPRCIYQCQMAKQSMAAVFHSVDHRVDTKLFDMKLPQKPLTRTK-HQTDL--------PFDEFNNGCNAVVAVISYTGYDMEDAM 672
                     689***************************************************.44444........49************************* PP

                     EEBCHHHHTTTT-EEEEEE..EEE--SSSS-.--.-S--..-...-SS-GGGS-TTSB--SS-EEETT-EEE---..B-----...--------- CS
  RNA_pol_Rpb2_6  98 ilnerlvdrdvftsihikeyeveardtklge.eeitrdipnv...seealkkLdedGivrvgaevkegdilvgkvtkgeteltpeekllraifge 188
                     i+n+ +++r++++ +++k+ +++  + +    ++++ + + +   + ++ ++Ld dG+++vg  + eg+i+ +++                   e
      EFC38462.1 673 IMNKTSYERGMMHGTVFKTEDIDLTEGTAFLtNRVFDKTEMDsdyQAKEFEDLDYDGLPEVGLPLDEGSIFANYY-----------------DPE 750
                     *******************888885444333244444433335668999*************************7.................223 PP

                     --..-B---EE--TT-EEEEEEEEE.......EE-TT--EEEEEEEEEEE---TT-BEEETTS---BBEEEB-TTTSEEETTS---SEEE-GGGC CS
  RNA_pol_Rpb2_6 189 karevkdtslrvksgeegvVdkvkvfsrekgdelkagvnklvkvyvaqkRklqvGDKfasrhGqKGvvslilpqeDmPfledGivvDivlNPlgv 283
                     k    k   ++ k+  +++V +vkv+    +d ++ ++ k + ++++ +R++ +GDKf+srhGqKGv+s+++pqeDmPf++ Giv+Div+NP+++
      EFC38462.1 751 K---QKFMPMKWKDVDSATVHSVKVI---ATDPSDYKKVKHASITFRLNRNPIIGDKFSSRHGQKGVLSILWPQEDMPFTDGGIVPDIVINPHAF 839
                     3...467889999999999*****95...556666788999****************************************************** PP

                     HHH-BTTHHHHHHHHHCCCSSSS--B--TT-......-.HHHHHHHHHTTS-TT-EE-EEETTTS-B-SS-EEB-EEEEEEBS--CCCS----SS CS
  RNA_pol_Rpb2_6 284 PSRmtigqllEtllgkaaalegkkvdatvFdgak...e.eeikelLeeagleasGkevlydGrtGekleaeifvGviYylkLkhlvedKihaRst 374
                     PSRmtig+l+E++ +ka+al+g + dat+F+ ++     +++ e+L++ag++++G+ev+y+G  G +l+a+i++Gv+Yy++L+h+v+dK++ R  
      EFC38462.1 840 PSRMTIGMLVESMSSKAGALHGYFPDATPFSFSEentAvDHFGEQLKKAGYNYHGNEVMYSGALGTTLKADIYMGVVYYQRLRHMVSDKYQCRVG 934
                     ******************************98775553699****************************************************** PP

                     --B-TTT--B-SCGGG CS
  RNA_pol_Rpb2_6 375 GpyslltqQPlgGkaq 390
                     Gp++++t+QP++G+++
      EFC38462.1 935 GPTNAITHQPVKGRKK 950
                     **************86 PP

>> RNA_pol_Rpb2_3  RNA polymerase Rpb2, domain 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.1   0.1   9.3e-26   2.1e-22       3      68 .]     366     429 ..     364     429 .. 0.97

  Alignments for each domain:
  == domain 1  score: 79.1 bits;  conditional E-value: 9.3e-26
  RNA_pol_Rpb2_3   3 ldrlnplselshlrrvsslrgglskerkttevRdlhpshwGriCpveTPEGencGlvksLallarv 68 
                     l+r+n+l+ +sh+r+ +  rg ++ ++++t++R+l ps wG+iCpv++P+G+ cGlv++L++++++
      EFC38462.1 366 LERINFLRVISHFRATH--RGIAFLDSNSTRMRRLTPSFWGFICPVHSPDGHLCGLVNHLSQTTEI 429
                     89***************..*******************************************9987 PP

>> RNA_pol_Rpb2_7  RNA polymerase Rpb2, domain 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.9   0.1   9.1e-24     2e-20       1      85 [.     952    1060 ..     952    1062 .. 0.97

  Alignments for each domain:
  == domain 1  score: 72.9 bits;  conditional E-value: 9.1e-24
                      BBEEEEHHHHHHHHHHTBHHHHHHHHTTTTTEEEEEEESSSSSCCCEE........................EBTTTTCSSSEEEEEEEHHHH CS
  RNA_pol_Rpb2_7    1 GGlrfGEMErdaliayGaaalLkerltikSDavevdvcgrckllaaan........................eCkivkseekiekveipeafk 69  
                      GG+r+GEMErdal+ayGaaa++k+r+++  D++++ vc+ c+ ++++                          C ++k+++++++++ip++ k
      EFC38462.1  952 GGVRMGEMERDALVAYGAAAVVKDRFFDCTDSSTAIVCTCCNQMNTIVkpdmgtgsgpivsgsgiganldelLCCVCKTNQHLRTIYIPYTTK 1044
                      9*******************************************99779***********************9******************** PP

                      HHHHHHHHTTBEEEEE CS
  RNA_pol_Rpb2_7   70 lLlqeLqslgialkll 85  
                       L  eL ++g++lk+ 
      EFC38462.1 1045 YLHSELAAMGVNLKIC 1060
                      ************9985 PP

>> RNA_pol_Rpb2_1  RNA polymerase beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.1   0.0   2.1e-16   4.7e-13      65     156 ..       1     312 [.       1     634 [. 0.77

  Alignments for each domain:
  == domain 1  score: 49.1 bits;  conditional E-value: 2.1e-16
                     S.HHHHHHCTSBXEEEEEEEEEEEECCCCTCCEEEEEEEEEEEEEXBTTSTTSSSTTS.HHHHHHTTS.TTS..SSEEETTCEEEEXEEEE.... CS
                     xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.... RF
  RNA_pol_Rpb2_1  65 iyPkearlrnltYsaplyvklklvvyekdnkeeikeeevyiGelPlMlrskacvlseaseeelvelkEcpldqGGyFiinGtekvivaqek.... 155
                     +yPk+ar+ ++ Y + l   + l+  e+    e  ++   + + P+M++s++c+l ++s+++ +  +E++++ GGyF+++G+e v + + +    
      EFC38462.1   1 MYPKDARIAGVNYGGSLKATILLKN-EETGAIERIPDIQLMEDFPVMINSSFCNLPKLSPKQKMLQGEEEHESGGYFVVRGSEVVYRLLTQqran 94 
                     79*******************9998.4556677777777899*******************99999*****************998777777788 PP

                     ............................................................................................... CS
                     ............................................................................................... RF
  RNA_pol_Rpb2_1 156 ............................................................................................... 155
                                                                                                                    
      EFC38462.1  95 fpfaitrpswmgykedftdkgilvrcrhpktlitrlvnihyrrdgvvfmragnpvpfyinivlalkalrecsdrdlfllltagtknkvtldrvve 189
                     99999888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888 PP

                     ............................................................................................... CS
                     ............................................................................................... RF
  RNA_pol_Rpb2_1 156 ............................................................................................... 155
                                                                                                                    
      EFC38462.1 190 llgdfrktfptvqtredaiialgtiydphglrrleepvdknkliksgyekfdflvycvqklykfvdgeiaeenlddfdnhelltvgevlsnvipl 284
                     88888888888888888888888888888888888888888888888888888888888888887777777777777777777555555555555 PP

                     ...........................X CS
                     ...........................x RF
  RNA_pol_Rpb2_1 156 ...........................l 156
                                                +
      EFC38462.1 285 iiynkiqlahgtcakllmksattmqpdM 312
                     5555555555555555555555555550 PP

>> RNA_pol_Rpa2_4  RNA polymerase I, Rpa2 specific domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.9   0.0   3.9e-15   8.6e-12       1      58 []     477     537 ..     477     537 .. 0.93

  Alignments for each domain:
  == domain 1  score: 44.9 bits;  conditional E-value: 3.9e-15
  RNA_pol_Rpa2_4   1 iGyvspkeakavaktLRrlKvegekkvpltlEIglvppsk...ggqYpGLYlftspaRmmR 58 
                     iG+vs+++++++a++LR++Kv+g++++p+ +EI++ p+ +       p L +ft+ aR +R
      EFC38462.1 477 IGKVSHDKLQNLADQLRYCKVSGKYGLPKFMEIACQPKYSamdIPYLPQLNIFTDIARAVR 537
                     8**************************************65745555***********999 PP

>> RNA_pol_Rpb2_2  RNA polymerase Rpb2, domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.1   1.6e-06    0.0036      48     189 ..     149     271 ..     128     272 .. 0.84
   2 ?   -0.8   0.0      0.44   9.8e+02      60      81 ..     902     923 ..     897     933 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.6e-06
                     SSSEEEHHHHHHHTT--STTHHHHHHTS....SSTTHHHHHHHHHHHHHHCTSSSCHHHHHHHHHCSSTTSSSCCCCCHHHHHHHCHHHHHHHTT CS
  RNA_pol_Rpb2_2  48 kkrkipivivlkAlglvsdreIlericy....dsedsqlleelleeleekeeiqtqeealdyigkvvalrrgeearlqsareilqkrydlgeigr 138
                     +  +i+iv+ lkAl   sdr+ +  ++     + + +++ e+l +  +    +qt+e+a+  +g        ++  l++ +e          +++
      EFC38462.1 149 VPFYINIVLALKALRECSDRDLFLLLTAgtknKVTLDRVVELLGDFRKTFPTVQTREDAIIALGT-----IYDPHGLRRLEEP---------VDK 229
                     56689*********************966776777788899999999999**************7.....7888889888855.........799 PP

                     TTSSTTTTTSSSTCHH..HHHHHHHHHHHHHHHHTTSSSS--TTSGGGEEE CS
  RNA_pol_Rpb2_2 139 eklnkhlglseslenkrlkaqdilymidrLlslklgrrevDDiDhlgnkRv 189
                     +kl     +s     +  k+ +++y +++L++   g++ +++ D++ n ++
      EFC38462.1 230 NKLI----KSGY---E--KFDFLVYCVQKLYKFVDGEIAEENLDDFDNHEL 271
                     9999....3333...3..89**************************99886 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.44
                     HTT--STTHHHHHHTSSSTTHH CS
  RNA_pol_Rpb2_2  60 AlglvsdreIlericydsedsq 81 
                     Alg + + +I+ +++y +   +
      EFC38462.1 902 ALGTTLKADIYMGVVYYQRLRH 923
                     9**************9333222 PP

>> RNA_pol_Rpb2_4  RNA polymerase Rpb2, domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   3.1e-06     0.007       1      58 [.     470     539 ..     470     540 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 3.1e-06
                     EECTT-BEEE..-S-HCCHHHHHHHHCCTTS..S-TT-EEEE-TT........T--EEEE-SSEEB-EEE CS
  RNA_pol_Rpb2_4   1 VfvNGrllGv..trdpkklvetlRelRRkgk..iseevsivlnek........qkevkiatDgGRvcRPl 58 
                     V ++G ++G   +++ ++l+++lR ++ +gk  ++++++i+++ k          +++i+tD  R++RP+
      EFC38462.1 470 VMLDGAIIGKvsHDKLQNLADQLRYCKVSGKygLPKFMEIACQPKysamdipyLPQLNIFTDIARAVRPV 539
                     889******84455669************997889**********88888888788*************7 PP

>> Ribosomal_L17  Ribosomal protein L17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00036       0.8       5      38 ..     419     452 ..     416     522 .. 0.77
   2 ?   -2.1   0.1       3.3   7.4e+03      53      81 ..     917     945 ..     887     951 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00036
                    HHHHHHHHSEEEEEHHHHHHHHHHHHHHHHHHHH CS
  Ribosomal_L17   5 lvtsLleherIetTlakAkelrklaeklitlakk 38 
                    lv++L ++ +I+t +ak kelr+++e +++l+  
     EFC38462.1 419 LVNHLSQTTEIVTHQAKPKELRSVVEMCLKLGML 452
                    7899999***********************9974 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 3.3
                    HHHHHHHTHHHHTSS--S--EEEEEEEE- CS
  Ribosomal_L17  53 lvkkLfeelapryadrngGYtRilklgpr 81 
                    + ++L + +  +y+ r gG t  +  +p 
     EFC38462.1 917 YYQRLRHMVSDKYQCRVGGPTNAITHQPV 945
                    57889999999******998887766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1069 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.83u 0.31s 00:00:01.13 Elapsed: 00:00:00.48
# Mc/sec: 6682.40
//
Query:       EFC38463.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.4e-35  120.9   0.0      8e-35  120.6   0.0    1.1  1  G-alpha     G-protein alpha subunit
  ------ inclusion threshold ------
      0.011   15.6   0.1      0.014   15.3   0.1    1.1  1  AAA_21      AAA domain, putative AbiEii toxin, Type IV TA sys
      0.016   14.9   0.0      0.019   14.7   0.0    1.2  1  AAA_15      AAA ATPase domain
      0.031   14.8   0.2      0.043   14.3   0.3    1.5  1  ABC_tran    ABC transporter
      0.045   13.6   0.1       0.23   11.4   0.0    1.9  2  Luteo_coat  Luteovirus coat protein
      0.048   13.4   0.1      0.091   12.5   0.1    1.4  1  AAA_29      P-loop containing region of AAA domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  120.6   0.0   2.7e-38     8e-35      19     203 ..      25     196 ..      12     215 .. 0.85

  Alignments for each domain:
  == domain 1  score: 120.6 bits;  conditional E-value: 2.7e-38
                 XE..EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH........ CS
     G-alpha  19 kkkrevkllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliaklssate 117
                 kk++  +lll+G+++SGKsTi+kqlk+l+ +gf  +el+++r++i  n+ r++ +++ a ++l++++     +qe+ er d +  + a+  a+      
  EFC38463.1  25 KKSNGKRLLLVGAGDSGKSTIFKQLKRLFSQGFAPDELQNLRPYILDNVSRNMINLCYATQQLNIPI-----DQENIERRDLFAGMYADTRAS------ 112
                 4445669************************************************************.....555555555554444443222...... PP

                 ..HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCG.CCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEE CS
     G-alpha 118 eeqeiefnpraevgedikaLwndpgiqelyerr.nkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdskle 203
                   +   +n   ++++d+k Lw+d gi+  ++++   +++ed+a y++d++e++++p+++p ++Dil++r+ktvG  e +f v+ +++
  EFC38463.1 113 MANAKKWNA--NTANDFKLLWKDNGIKTAFRQYrGTYQIEDGAPYYFDKIEELANPEWVPLEEDILRTRIKTVGLVEQQFVVK-EMN 196
                 126666666..78******************8878999******************************************996.443 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.3   0.1   4.5e-06     0.014       3     153 ..      33     169 ..      32     185 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 4.5e-06
      AAA_21   3 vliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldlydpeipfefeieeflsqgvryryglrlersqveeklssvetllesgllld 101
                 +l+G+  sGKS++++ l+ l++ ++ + ++  +l+++    + ++ ++l++ ++  ++ i++ +++  +   g+  + ++              +   +
  EFC38463.1  33 LLVGAGDSGKSTIFKQLKRLFS-QGFAPDELQNLRPYILDNVSRNMINLCYATQQLNIPIDQENIERRDLFAGMYADTRAS-------------MANAK 117
                 69*******************9.**************99999999999999999999999955555555555444444444.............66666 PP

      AAA_21 102 krsleeedvfnpeargirggvsvfslkelsvsepndlqfgkaltditsraws 153
                 k++++  ++f   ++++ +    ++ +    +e+ +++ ++ + ++ ++ w 
  EFC38463.1 118 KWNANTANDFKLLWKDNGIKTAFRQYRGTYQIEDGAPYYFDKIEELANPEWV 169
                 6666666666666666666555555555555555555555555555555555 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.0   6.3e-06     0.019      27      83 ..      33      95 ..      25     189 .. 0.62

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 6.3e-06
      AAA_15 27 vliGkNnsGKSsilealdlFlnnkekkn..........kkvikiekedleifeniseskdikIdvef 83
                +l+G+ +sGKS+i + l+ ++++    +          +  +++  + ++ + +     +i Id e 
  EFC38463.1 33 LLVGAGDSGKSTIFKQLKRLFSQG---FapdelqnlrpYILDNVSRNMINLC-YATQQLNIPIDQEN 95
                89********************77...3344455565533334444444444.33333333333333 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.3   1.5e-05     0.043       6      37 ..      24      55 ..      20     199 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.5e-05
                EEEETTSEEEEEESTTSSHHHHHHHHTTSS-- CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  6 lklkegekvaivGenGaGKStLlkllagllkp 37
                +k ++g+++ +vG   +GKSt++k l +l ++
  EFC38463.1 24 VKKSNGKRLLLVGAGDSGKSTIFKQLKRLFSQ 55
                56689*********************999875 PP

>> Luteo_coat  Luteovirus coat protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   7.7e-05      0.23      92     131 ..     109     147 ..      88     154 .. 0.79
   2 ?   -0.1   0.0      0.26   7.7e+02      46      81 ..     186     222 ..     171     230 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 7.7e-05
  Luteo_coat  92 fraeiingkefqesskdqffllykgnGkstdvaGsfriti 131
                  ra + n k+++  + + f ll+k nG  t    ++r t 
  EFC38463.1 109 TRASMANAKKWNANTANDFKLLWKDNGIKTA-FRQYRGTY 147
                 578999*********************6653.34555544 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.26
  Luteo_coat  46 ikvefkseasatdaGaiayeldtackks.alvsyvnk 81 
                 +  +f+ +    ++G++ +++ t+   s   +s++n+
  EFC38463.1 186 VEQQFVVKEMNVKSGCVTLRMSTQLYMSvVYQSLINR 222
                 4567888888899999999999995554156788875 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   3.1e-05     0.091      22      39 ..      28      46 ..      19      55 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.1e-05
      AAA_29 22 kg.atlltGpsGsGKSTll 39
                +g   ll+G+  sGKST++
  EFC38463.1 28 NGkRLLLVGAGDSGKSTIF 46
                45589************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.46u 0.33s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1513.46
//
Query:       EFC38464.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       717  (0.0399911); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.55
# Mc/sec: 1625.84
//
Query:       EFC38465.1  [L=449]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (449 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       721  (0.0402142); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 2477.77
//
Query:       EFC38466.1  [L=513]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (513 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       850  (0.0474092); expected 358.6 (0.02)
Passed bias filter:                      525  (0.0292822); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.54
# Mc/sec: 2876.18
//
Query:       EFC38467.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.8e-62  211.8   0.0      2e-62  211.6   0.0    1.0  1  Amidohydro_2  Amidohydrolase


Domain annotation for each model (and alignments):
>> Amidohydro_2  Amidohydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  211.6   0.0   1.1e-66     2e-62       1     290 [.       8     338 ..       8     339 .. 0.98

  Alignments for each domain:
  == domain 1  score: 211.6 bits;  conditional E-value: 1.1e-66
                   EEEEEEE..SHHH.................................CCCCCCGGCTSCCCHHHHHCHHTSSECCCEHCHHHHHHHHTSHHCHHHHHH CS
  Amidohydro_2   1 iDvHaHllppeaa.................................irddgepngfdpeerlafmkragvdpqlaspeallvlnaaagiaravivaa 64 
                   iD+H+H+lp   +                                  ++++e n++ pe rl++mk+ gv+ q +s++++++ +    +a++++  +
    EFC38467.1   8 IDMHVHILPSTVPdwkeefgyggfisieqettsdnkvkanmmkdgqFFRAVEENCWNPEARLEDMKKTGVTAQVLSTVPVMFNY----WAKPNDALK 100
                   9*******99999***********************************************************************....********* PP

                   HHHHHHHHHHHHHHHHCTTCBECEEECTSSHCHHHHHHHHHHHHTTECEEEEESSTTTCCTTTCGGHHHHHHHHHHHT-EEEEE............. CS
  Amidohydro_2  65 lcrgannrvlaeaakrpdrfvggaavvpldpedaaaeleraveelgfkGvrlnphvggddllgdrldrpifealeelglpvdihtGps......... 152
                   +  ++n++++  + k+ d f+g+++v+++ p+ a +e++r++eel + G+++++h ++  l+++ l+ pife ++el++p++ih  p+         
    EFC38467.1 101 TSMFLNDDIANTCNKYEDYFLGLGTVPMQAPDLACKEIRRCMEELHLSGIQIGSHINNYCLDDPSLF-PIFETAAELDCPIMIH--PWqmigsdlmk 194
                   *******************************************************************.****************..99********* PP

                   ...CHHHCHHHHHHHHHHHHHHHCCHHHHCTTSEEEESGGGTTTTCHHHHHHHHHHHHHCCEEECCGHHH.........SSEEECCHHCHHHHHHHH CS
  Amidohydro_2 153 ...pewlfggpqettraiqplllsgvarkfPnlkivlaHgGgpserlraalellarrpnvyvklsglyte.........llyfdspladppalarli 237
                       +wl+g+p+ett ai++l+++gv++k+Pnlk++++HgGg    ++ ++ +++++ nv+ +l+ +  +         + + d+  +d  al++l+
    EFC38467.1 195 kywLPWLVGMPAETTLAICSLIFGGVLEKLPNLKVCFSHGGGS---FPYTIGRIEHGYNVRPDLCQVD-CkvnprdfcgKIWADTITHDDDALKLLV 287
                   *******************************************...********************64.36************************** PP

                   HHH-GGGEEEE--BTSTTSTSCTTHHHHCHHHHHSSHHHHHHHHTHHHHHHCT CS
  Amidohydro_2 238 eavgpdrilfGsDyPhptleaepealalldlvallsdeerekilggNAarlyg 290
                   +++g dr++ GsDyP+p +e++p+ l++    +  s+e+++k+l+ N  ++++
    EFC38467.1 288 KVFGDDRVMLGSDYPFPLGEHHPGKLVEDSTSF--SQEQKDKLLYYNTKEFLN 338
                   ***************************999888..************999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       300  (0.0167327); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 1905.06
//
Query:       EFC38468.1  [L=257]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.8e-13   50.0   0.0    5.1e-13   49.6   0.0    1.3  1  4HBT_2       Thioesterase-like superfamily
    7.6e-05   22.1   0.9    0.00023   20.5   0.4    1.9  2  Acyl-ACP_TE  Acyl-ACP thioesterase
  ------ inclusion threshold ------
      0.027   14.8   0.0      0.048   14.0   0.0    1.3  1  4HBT         Thioesterase superfamily


Domain annotation for each model (and alignments):
>> 4HBT_2  Thioesterase-like superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.6   0.0   8.5e-17   5.1e-13       1     111 [.      70     177 ..      70     240 .. 0.88

  Alignments for each domain:
  == domain 1  score: 49.6 bits;  conditional E-value: 8.5e-17
      4HBT_2   1 vrpndvDlnghlnnarylryleearvkflertglksrsiarrgiglilssahvryrrplkfpdrltvefrvididaktliiehrflsnadgkk.aarve 98 
                 v+p d+D n h+nna+yl  +e +rv ++  tgl +  ++++++ + l     ++r+ +  ++ ++ e++vi +d+k +++e+ + +    ++   r++
  EFC38468.1  70 VTPFDLDWNLHMNNAQYLTAMELGRVSYFLTTGL-QTRARKLKVNPLLMGVSFQFRKDVGCFTNIKLETQVISYDDKFMYFEQTLST--GKHQhIGRGI 165
                 7889**********************99999***.8888899*******************************************77..7777789*** PP

      4HBT_2  99 erivvmdygkrsk 111
                  r+++ ++gk+ +
  EFC38468.1 166 ARVGFAQRGKG-L 177
                 *****999996.3 PP

>> Acyl-ACP_TE  Acyl-ACP thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.4   3.9e-08   0.00023     133     181 ..      40      90 ..      18     101 .. 0.75
   2 ?   -1.3   0.0      0.18   1.1e+03      74     105 ..     132     163 ..     123     166 .. 0.83

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 3.9e-08
  Acyl-ACP_TE 133 eeseeklkkkpktkvleak..eeseekelkvrysDlDlnqHvNNvkYlewi 181
                  +++ee++ ++  + v++++   +++++++ v  +DlD n H+NN++Yl  +
   EFC38468.1  40 KKQEEQVSHHHAEDVYHEIvpSHKHVTHYLVTPFDLDWNLHMNNAQYLTAM 90 
                  455566666666666666511566778999*****************9865 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.18
  Acyl-ACP_TE  74 kveietwaesenklfcyrdfkvrdekgekiie 105
                   ++ et++ s+   f+y + ++   k ++i++
   EFC38468.1 132 NIKLETQVISYDDKFMYFEQTLSTGKHQHIGR 163
                  58999******999999998888877777765 PP

>> 4HBT  Thioesterase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0     8e-06     0.048       3      74 ..      80     157 ..      79     161 .. 0.95

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 8e-06
                 SB-HHHHHHHHHHHHHHHHHHTTST......TEEEEEEEEEEEESS-BBTTCEEEEEEEEEEEESSEEEEEEEEEETT CS
        4HBT   3 vvhgGvylallDeaagaalrslggr......gilvvvvelsidflrpvrlgdeltvearvlrlgrtsavvevevrded 74 
                 ++++++yl++++ ++  ++ + g+       +  +     s +f++ v +   + +e++v+    + +++e+++ +++
  EFC38468.1  80 HMNNAQYLTAMELGRVSYFLTTGLQtrarklKVNPLLMGVSFQFRKDVGCFTNIKLETQVISYDDKFMYFEQTLSTGK 157
                 89*****************************9999999*********************************9998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1508  (0.0841095); expected 358.6 (0.02)
Passed bias filter:                      641  (0.0357521); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1647.43
//
Query:       EFC38469.1  [L=834]
Description: rasGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.7e-31  107.5   5.4    2.2e-30  106.1   5.1    1.9  2  RasGEF           RasGEF domain
  ------ inclusion threshold ------
       0.16   10.4   0.0       0.23    9.8   0.0    1.1  1  Gag_spuma        Spumavirus gag protein
       0.18   10.5   3.0       0.33    9.7   3.0    1.3  1  Tim54            Inner membrane protein import complex subuni
       0.59   10.6  11.7        1.5    9.3  11.7    1.6  1  CENP-B_dimeris   Centromere protein B dimerisation domain
       0.69    9.3  10.4        1.4    8.2  10.4    1.4  1  CobT             Cobalamin biosynthesis protein CobT
        1.3    8.2   9.9        2.3    7.4   9.9    1.3  1  TRAP_alpha       Translocon-associated protein (TRAP), alpha 
        1.4    9.2   8.7        1.7    8.9   4.7    2.5  2  MPM1             Mitochondrial peculiar membrane protein 1
        1.6    8.1   5.0        3.2    7.1   5.0    1.5  1  DUF4820          Domain of unknown function (DUF4820)
        1.6    6.8  15.9          3    5.9  15.9    1.3  1  Nop14            Nop14-like family


Domain annotation for each model (and alignments):
>> RasGEF  RasGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       6.6   1.3e+04      36      52 ..     402     417 ..     380     424 .. 0.69
   2 !  106.1   5.1   1.1e-33   2.2e-30       1     168 [.     487     698 ..     487     708 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 6.6
      RasGEF  36 veaviarfnrlsnwvas 52 
                 v+ v ++fn+ls ++ s
  EFC38469.1 402 VD-VSEMFNKLSSFILS 417
                 44.67889999888765 PP

  == domain 2  score: 106.1 bits;  conditional E-value: 1.1e-33
      RasGEF   1 elAeqltliea.elfskikpeellgsawskedrspnveaviarfnrlsnwvaseilseeslkkRakviekfikiakecrklnNfnslmailsaLqsspv 98 
                 e+A+qlt +e+ + f+++k ++++++   + ++++n++++i+rfn +s w++++il++esl++R+k+i +f++++    +l+N++ +m+i+sa+++s++
  EFC38469.1 487 EIAKQLTNYEFtNHFEQCKTHDFFSTGALS-NNQSNLDQMIDRFNWMSLWIVYTILRQESLENRVKIIGYFVQVMFFTLSLQNYQNTMCIISAFHNSCI 584
                 79*********99************65222.24589*************************************************************** PP

      RasGEF  99 srLkktweavskkslktle.........eleelmspennfknyrealkssa.................sskpciPflglyltdltfieegnpdtl.... 167
                 s+L  +w++vs+  +++ +          ++ l+s +++f ++       +                 ++ +ciP++g++l ++  ie+ ++d++    
  EFC38469.1 585 SKLATAWKEVSEL-RDQTNaftyhqfleGVNDLLSLQKKFFKL-------KyhiiqnietslenneegTQFSCIPYVGVWLGEISSIETYYNDFVsppt 675
                 ***********33.22222343444444444455555555555.......1333333467777777998888************999999888886666 PP

      RasGEF 168 ......................e 168
                                       +
  EFC38469.1 676 hlkqhhshisnsnttlhthqypH 698
                 66555555555555555555554 PP

>> Gag_spuma  Spumavirus gag protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00012      0.23     409     469 ..     562     622 ..     540     637 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00012
   Gag_spuma 409 mmlsgqnyqlvsgiirgylpgqavvtamqqrldqeiddqtraetfiqhlnavyeilglnar 469
                 + ls qnyq    ii  +        a   +   e+ dqt a t+ q l+ v ++l l+ +
  EFC38469.1 562 FTLSLQNYQNTMCIISAFHNSCISKLATAWKEVSELRDQTNAFTYHQFLEGVNDLLSLQKK 622
                 45899**************99999999999999***********************99866 PP

>> Tim54  Inner membrane protein import complex subunit Tim54
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   3.0   0.00017      0.33     204     276 ..     365     434 ..     346     455 .. 0.41

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00017
       Tim54 204 eeeeeeeekeeeeeeeeeeeeekeeekeeekeeeeeeeekekkkkvpkpyispedYasae..l.ppeiPellqpvl 276
                 eeee++ee+++e++      ee+e ++ ee+ e+e+eee+e++  v + +++ +++  ++  l ++eiPe++ +  
  EFC38469.1 365 EEEENAEEETQEAD------EEEEYTQVEEEGEDEDEEEEEEEVDVSEMFNKLSSFILSQhdLqATEIPEVFANQE 434
                 11111111222222......22222222222222222222333444444555444432220021333555554333 PP

>> CENP-B_dimeris  Centromere protein B dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3  11.7   0.00074       1.5       7      63 ..     368     424 ..     362     442 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00074
  CENP-B_dimeris   7 eagedsesesdeeeeeeeedeededeeddedddevpvpsfgeamayfamvkryltsf 63 
                     e+ e+   e+deeee  + +ee ede+++e+++ev v  + + ++ f + +  l + 
      EFC38469.1 368 ENAEEETQEADEEEEYTQVEEEGEDEDEEEEEEEVDVSEMFNKLSSFILSQHDLQAT 424
                     56677788999999999999******************9999999998887776655 PP

>> CobT  Cobalamin biosynthesis protein CobT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2  10.4   0.00071       1.4     205     247 ..     358     401 ..     320     419 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00071
        CobT 205 eesaeepeeedeeeeedeeeeeeeseee.eeegedddkeeqeea 247
                 +e++ ++eee+++eee++e +eee+ ++ eeeged+d+ee+ee+
  EFC38469.1 358 KELGLDEEEEENAEEETQEADEEEEYTQvEEEGEDEDEEEEEEE 401
                 55666666666666666666666666655555555555544443 PP

>> TRAP_alpha  Translocon-associated protein (TRAP), alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   9.9    0.0011       2.3      29     100 ..     357     429 ..     341     435 .. 0.68

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0011
  TRAP_alpha  29 aeedevddelvdveaedeeveeeeeeeeeeeeeeeedeeelkaspdadttilFtkpv..ekaeeelpageivef 100
                 ++e  +d+e ++ +ae+e++e +eeee ++ eee ede+e +++ ++d   +F k      ++++l+a ei e+
  EFC38469.1 357 RKELGLDEEEEE-NAEEETQEADEEEEYTQVEEEGEDEDEEEEEEEVDVSEMFNKLSsfILSQHDLQATEIPEV 429
                 444456666333.4455555555555566677777777778888889999999987766788999999998775 PP

>> MPM1  Mitochondrial peculiar membrane protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.21   4.1e+02     120     164 ..      34      81 ..      11      88 .. 0.70
   2 ?    8.9   4.7   0.00086       1.7      65     128 ..     342     404 ..     308     436 .. 0.68

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.21
        MPM1 120 sekds...kkkvvssssktsvntteegneeklkevktyfddgtvkvkk 164
                 s+ ++   + + +s+ss+ sv++++e+ + +l e+ +yf  g +  ++
  EFC38469.1  34 SKLEEsqvHLSEISTSSSPSVHQQPENPNSSLFELSNYFGIGHLLDET 81 
                 2222222256789**************99********99888766555 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00086
        MPM1  65 yGlFFkeftdyLnWksemkelikekreeeikkkkeeekkkkesektkedlmlkkssekdskkkv 128
                   l F+++++yL+ k+++  l +e++e+++++ +e +++++ ++  +e+ + ++++e++++ +v
  EFC38469.1 342 FPLSFNDWSEYLSNKRKELGLDEEEEENAEEETQEADEEEEYTQ-VEEEGEDEDEEEEEEEVDV 404
                 4567*************999999998888888887777666655.4455554444444333333 PP

>> DUF4820  Domain of unknown function (DUF4820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   5.0    0.0016       3.2     170     217 ..     365     412 ..     311     420 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0016
     DUF4820 170 erksekesaesseskkrnkeerdaeseeessedeeeeetvkellekya 217
                 e++++ e+++++++++++  + ++e e+e +e+eeee  v+e+ +k+ 
  EFC38469.1 365 EEEENAEEETQEADEEEEYTQVEEEGEDEDEEEEEEEVDVSEMFNKLS 412
                 333444445555555556666777788888888899999******986 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  15.9    0.0015         3     313     388 ..     324     404 ..     306     444 .. 0.52

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0015
       Nop14 313 e.......asaDdldddfvleeeeeeeefglgkglkataeee.eeededdfeedddlveseseeee..eeeeedeeeeedeeeeee 388
                 e       +s+D+l++  +  + ++ +e+      +++++e+  +e+e+++ e+++++++e+ee +  eee+ede+eee+eee + 
  EFC38469.1 324 ElsgvlklISEDSLNQHAFPLSFNDWSEYL-----SNKRKELgLDEEEEENAEEETQEADEEEEYTqvEEEGEDEDEEEEEEEVDV 404
                 234455557888888888888887777665.....223445533333333333333333333322222333333333333333321 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (834 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2106  (0.117463); expected 358.6 (0.02)
Passed bias filter:                      788  (0.0439511); expected 358.6 (0.02)
Passed Vit filter:                       116  (0.00646996); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.99u 0.39s 00:00:01.38 Elapsed: 00:00:00.59
# Mc/sec: 4252.75
//
Query:       EFC38470.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.6e-07   29.4   0.0    1.1e-06   28.7   0.0    1.4  1  MMR_HSR1        50S ribosome-binding GTPase
    6.7e-07   29.4   0.4     0.0091   15.9   0.1    2.3  2  RsgA_GTPase     RsgA GTPase
    1.2e-05   25.0   0.6     0.0016   18.0   0.1    2.2  2  GTP_EFTU        Elongation factor Tu GTP binding domain
    0.00014   22.2   0.1    0.00047   20.5   0.1    2.1  1  RNA_helicase    RNA helicase
    0.00048   19.5   0.1    0.00099   18.5   0.0    1.6  1  Septin          Septin
     0.0021   18.3   0.1      0.033   14.4   0.0    2.2  2  AAA_22          AAA domain
     0.0047   17.3   0.0     0.0069   16.8   0.0    1.4  1  AAA_16          AAA ATPase domain
  ------ inclusion threshold ------
       0.01   15.8   0.0      0.019   14.9   0.0    1.4  1  AAA_5           AAA domain (dynein-related subfamily)
      0.039   13.1   0.0      0.095   11.9   0.0    1.6  1  NB-ARC          NB-ARC domain
      0.057   14.0   0.0       0.13   12.8   0.0    1.8  1  AAA_18          AAA domain
      0.061   13.7   0.1       0.26   11.7   0.0    2.1  2  AAA             ATPase family associated with various cellula
      0.063   12.8   0.3       0.13   11.8   0.1    1.6  2  AAA_7           P-loop containing dynein motor region
      0.084   12.6   0.0        0.2   11.3   0.0    1.6  1  IstB_IS21       IstB-like ATP binding protein
       0.12   12.1   0.0       0.28   10.9   0.0    1.6  1  AAA_24          AAA domain
       0.12   12.2   0.0       0.21   11.5   0.0    1.4  1  Ploopntkinase3  P-loop Nucleotide Kinase3
       0.13   12.4   0.4        1.1    9.5   0.0    2.2  2  Roc             Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.7   0.0     1e-09   1.1e-06       2     113 ..      80     230 ..      79     231 .. 0.59

  Alignments for each domain:
  == domain 1  score: 28.7 bits;  conditional E-value: 1e-09
                 EEEEESTTSSHHHHHHHHHT........S.TEEE..SSSTTSSSSEEEEEEE......ETT.EEEEEEECGGC.................SSHHHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltg........e.kaiv..sdkpgtTrdinegrvk......lkg.keielvDtpGl.................iegaseekg 65 
                 + ++G+p vGKS L n+l++        e +ai   s    +T+d +++ +         +  ++++vD  G                  ++++s++k+
  EFC38470.1  80 IWLFGQPGVGKSKLTNSLFKslhgvfdkEtVAISggSTNSHVTQDLKYIPLYspilsgG-KpGNVRVVDAWGNdgsnydptlfesilkgkVSNNSQQKS 177
                 789****************8666565432334443355557777777777666765442.2367********555565666555543333336666665 PP

                 HHHHHHH..HHCTSEEEEEEETTTTCSHHHHHHHHHHHHH....TTSEEEEEEE CS
    MMR_HSR1  66 lgkafla..leeadlillvvdaseeklkpldeeleellee....akkplilvln 113
                 l+ + ++   +++++i++vv as+ + +++ + ++++  +    ++   ilv++
  EFC38470.1 178 LKPSAKEdkSRQVHAIVFVVTASSCSSDQDCKMIAQYS-KiamqNNLYPILVIT 230
                 5555555224559*******988443344444444443.233333333455555 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.1   8.1e-06    0.0091      88     133 ..      66     115 ..      42     138 .. 0.69
   2 !   11.6   0.1   0.00017      0.19      21      65 ..     197     241 ..     179     275 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 8.1e-06
                  TTHHHHHHHCTTSEEEEECSTTSSHHHHHHHHCTT-....----S----- CS
  RsgA_GTPase  88 egleelkellkdktsvlvGqSGvGKStLinallpel....elktgevsek 133
                  + + + + ++++  + l Gq GvGKS L n+l  +l    + +t ++s  
   EFC38470.1  66 KRFFKESLNIEQTNIWLFGQPGVGKSKLTNSLFKSLhgvfDKETVAISGG 115
                  44444445566777889*************99887422225666666654 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00017
                  EEEESTTTT--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHHHH CS
  RsgA_GTPase  21 ivvslkepelslnlldrfLvlaeekgiepvivlnKiDlleeeeel 65 
                  +  s  + + + +++ ++  +a ++++ p++v++K+D+l+ee ++
   EFC38470.1 197 VTASSCSSDQDCKMIAQYSKIAMQNNLYPILVITKVDCLNEEFKT 241
                  22333347788899999999********************98733 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0     0.011        12       4      37 ..      78     111 ..      76     126 .. 0.82
   2 !   18.0   0.1   1.5e-06    0.0016      91     150 ..     187     250 ..     181     319 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.011
                 EEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH CS
    GTP_EFTU   4 rnigiighvDhGKtTLtdrLlyktgaiskkgeka 37 
                  ni + g    GK+ Lt +L ++++ + +k+++a
  EFC38470.1  78 TNIWLFGQPGVGKSKLTNSLFKSLHGVFDKETVA 111
                 5889999999*************99999988877 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 1.5e-06
                 HHT-SEEEEEEETT....TBSTHHHHHHHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHH CS
    GTP_EFTU  91 lrvlDgavlvvdav....eGvepqteevlrlalkegvpiivfiNKmDrlkaelkeiveevkqkl 150
                  r+++  v+vv a+    +  +    +  ++a ++++ +i++i+K+D l++e+k  +e++ ++ 
  EFC38470.1 187 SRQVHAIVFVVTASscssDQDCKMIAQYSKIAMQNNLYPILVITKVDCLNEEFKTHPEKIDSDP 250
                 68899999999998444344677778888899999999********************998766 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   4.2e-07   0.00047       1      43 [.      80     120 ..      80     201 .. 0.67

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 4.2e-07
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkkl............klkkkdsvysrnpeddf 43 
                   iwl+G++g+GKS l+++L k+l + +            +              ++
    EFC38470.1  80 IWLFGQPGVGKSKLTNSLFKSLHGVFdketvaisggstN--------------SH 120
                   8*********************98883333444443333..............33 PP

>> Septin  Septin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   8.8e-07   0.00099       5     179 ..      78     261 ..      74     287 .. 0.66

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 8.8e-07
                 EEEEEEEBTTSSCCCCCCTTSSSS..----..--------..------S-EEEEEEEEETTCEEEEEEEE---BSSSSSHHCCCHHHHHHHHHHHHHHH CS
      Septin   5 ftlmvvGesglGkttlintlfetd..liee..ekleease..kkkktveikkkkvvieedgvklnltviDtpgfGdavdnskswepiveyideqfeeyl 97 
                  ++ + G+ g+Gk+ l n+lf++   + ++    ++  s   + +++++     + i   g   n+ v+D  g   +    + +e i++   +  ++  
  EFC38470.1  78 TNIWLFGQPGVGKSKLTNSLFKSLhgVFDKetVAISGGSTnsHVTQDLKYIPLYSPILSGGKPGNVRVVDAWGNDGSNYDPTLFESILKGKVS--NNSQ 174
                 588999***************985113444332233333311344444444567788889999*******87653332234567777664333..2333 PP

                 HHCTSS--SS-----EEEEEEEE-TTSSSS-HHHHHHH...HHHTTTS-EEE..EESSGGGS-HHHHHHHHHHHHHH..HHHTT----- CS
      Septin  98 reesklkRkkivDkRvHaclyfisPtghglkpldvelm...kklsekvnliP..viaKaDtltkeElkefKkkiree..leeeeikiyk 179
                 ++  k + k+ + + vHa+++ ++ ++    + d +++    k++ + nl P  vi+K D+l  eE k+  +ki ++  +++  +++++
  EFC38470.1 175 QKSLKPSAKEDKSRQVHAIVFVVTASSCSS-DQDCKMIaqySKIAMQNNLYPilVITKVDCLN-EEFKTHPEKIDSDpaVKKAVMDVCQ 261
                 556677778888889******999877654.44655551116788899**985569*****95.6777777777664224444455555 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0     3e-05     0.033       5      35 ..      77     107 ..      75     143 .. 0.81
   2 ?    1.3   0.0      0.34   3.8e+02      37      62 ..     180     213 ..     159     222 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 3e-05
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeaka 35 
                 ++ + ++G++G+GK+ l + l+++l+ + + 
  EFC38470.1  77 QTNIWLFGQPGVGKSKLTNSLFKSLHGVFDK 107
                 677899******************9876544 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.34
      AAA_22  37 e.......erpevv.fvtlpsstsskdllrellr 62 
                         ++++ + fv  +ss+ss++ ++++++
  EFC38470.1 180 PsakedksRQVHAIvFVVTASSCSSDQDCKMIAQ 213
                 1344444545555569999999999999999986 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   6.2e-06    0.0069      25      69 ..      78     127 ..      66     194 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 6.2e-06
      AAA_16  25 elvllsGesGvGKsslvrellralekd...ggiflrgkcdql..esaipy 69 
                  ++ l G++GvGKs+l ++l+++l +    + ++++g  + +  ++++ y
  EFC38470.1  78 TNIWLFGQPGVGKSKLTNSLFKSLHGVfdkETVAISGGSTNShvTQDLKY 127
                 68999*****************9986555444445555444434445555 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   0.0   1.7e-05     0.019       2      47 ..      80     127 ..      79     150 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.7e-05
                 EEEE--SSSSHHHHHHHGGGGB..S--EEEEE--TT--HHHHH--B-- CS
       AAA_5   2 vlLvGppGtgKselaerlaaal..nreveyvqltrdtteedlkgrrei 47 
                 + L G+pG+gKs+l+ +l + l      e+v+++ + t +++++ +++
  EFC38470.1  80 IWLFGQPGVGKSKLTNSLFKSLhgVFDKETVAISGGSTNSHVTQDLKY 127
                 5699******************998999**************999876 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   8.4e-05     0.095      14      71 ..      71     124 ..      59     127 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 8.4e-05
                 CTTTSCSEEEEEEESTTSSHHHHHHHHCCSHCCCCCCBTEEEEEEEESXXHHHHHHHX CS
      NB-ARC  14 ekdelqslvvalvGmgGvGKttlakqilnksdevegrFdsvawvvvsktdkseeilet 71 
                 e+ ++++  + l G +GvGK+ l ++ +++   ++g Fd    v +s  ++ ++++++
  EFC38470.1  71 ESLNIEQTNIWLFGQPGVGKSKLTNSLFKS---LHGVFDKE-TVAISGGSTNSHVTQD 124
                 46677888899*****************99...99999975.4788888888888876 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   0.00012      0.13       1      25 [.      80     115 ..      80     192 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 0.00012
      AAA_18   1 IlltGtpGvGKttlakeLskrl.gf..........g 25 
                 I+l G pGvGK+ l++ L k+l g+          g
  EFC38470.1  80 IWLFGQPGVGKSKLTNSLFKSLhGVfdketvaisgG 115
                 89****************888756656555555542 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00023      0.26       2      35 ..      81     118 ..      80     149 .. 0.82
   2 ?   -1.2   0.0       2.2   2.5e+03      42      72 ..     207     237 ..     164     259 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00023
                 EEESSTTSSHHHHHHHHHHHHT....HEEEEEETTTCS CS
         AAA   2 llyGppGtGKTllakavakelg....vefleisgsell 35 
                  l+G pG+GK+ l +++ k+l+     e + isg +  
  EFC38470.1  81 WLFGQPGVGKSKLTNSLFKSLHgvfdKETVAISGGSTN 118
                 699*****************954444778888887766 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 2.2
                 HHHHHHHHHHHHHHTSTS.EEEEEETGGGHHH CS
         AAA  42 sekkirelfkeakekakp.silfiDEidalak 72 
                   k i+++ k a +++    il+i  +d l++
  EFC38470.1 207 DCKMIAQYSKIAMQNN-LyPILVITKVDCLNE 237
                 4445555555555555.447777777776654 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       2.7   3.1e+03      46      83 ..      15      51 ..      15      69 .. 0.61
   2 ?   11.8   0.1   0.00011      0.13      23      79 ..      67     123 ..      50     126 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.7
       AAA_7 46 Ktviikdllkkldkekylsltinfsaqtsanqlqdiie 83
                K++ i++ ++k++ ++++++  +  ++  ++ql ++i+
  EFC38470.1 15 KSSNIRKKMQKFE-SSFNFKASTPVSSSPSSQLSSLIQ 51
                6777777777777.555554444444455555555555 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 0.00011
       AAA_7  23 syllelllknkkpvllvGptGtGKtviikdllkkldkekylsltinfsa.qtsanqlq 79 
                 +++ e l  ++ ++ l G+ G+GK+ ++++l+k+l+   +   t+ +s  +t+++ +q
  EFC38470.1  67 RFFKESLNIEQTNIWLFGQPGVGKSKLTNSLFKSLH-GVFDKETVAISGgSTNSHVTQ 123
                 4566677778999*********************99.888888887775244555555 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00018       0.2      46      67 ..      76      97 ..      48     104 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00018
   IstB_IS21 46 kkenivllGpsGvGKshlaial 67
                ++ ni l+G++GvGKs l+ +l
  EFC38470.1 76 EQTNIWLFGQPGVGKSKLTNSL 97
                678***************9987 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00025      0.28       3      22 ..      78      97 ..      76     124 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00025
      AAA_24  3 lkiliyGpsgiGKTtlakel 22
                 +i+++G++g+GK+ l ++l
  EFC38470.1 78 TNIWLFGQPGVGKSKLTNSL 97
                68**************9998 PP

>> Ploopntkinase3  P-loop Nucleotide Kinase3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00019      0.21       5      28 ..      79     102 ..      75     122 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00019
  Ploopntkinase3   5 liylvGqPGaGkstlmaeltkgfd 28 
                      i+l GqPG Gks+l  +l k+++
      EFC38470.1  79 NIWLFGQPGVGKSKLTNSLFKSLH 102
                     59**************99998875 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00098       1.1       2      39 ..      80     117 ..      79     129 .. 0.70
   2 ?    0.5   0.1      0.61   6.8e+02      79     119 ..     189     233 ..     181     234 .. 0.60

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00098
                 EEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEE CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfsekekstigvdfltk 39 
                 + l G+ gvGK++l +++ ++      k+t++++  ++
  EFC38470.1  80 IWLFGQPGVGKSKLTNSLFKSLHGVFDKETVAISGGST 117
                 6799*************998665555555555554443 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.61
                 TSCEEEEEEE.GH.HHHCHHHHHHHHHHHCSSS-E..EEEEE-TT CS
         Roc  79 eaalailvyd.sr.ssenlkeWlkelkkvagkspv..ilvgnkiD 119
                 + +++++v++ s+ ss++  + + + +k a ++++  ilv++k+D
  EFC38470.1 189 QVHAIVFVVTaSScSSDQDCKMIAQYSKIAMQNNLypILVITKVD 233
                 556666666633323333345666666666555432489999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1071  (0.0597356); expected 358.6 (0.02)
Passed bias filter:                      613  (0.0341904); expected 358.6 (0.02)
Passed Vit filter:                       112  (0.00624686); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.56
# Mc/sec: 1825.54
//
Query:       EFC38471.1  [L=1847]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.2e-18   64.4  35.5      4e-09   34.3   0.0    5.2  5  GREB1           Gene regulated by oestrogen in breast cancer
  ------ inclusion threshold ------
      0.039   14.1   8.3        1.4    9.0   7.9    2.9  2  DDHD            DDHD domain
        1.1    9.8   5.0        1.1    9.8   1.8    2.8  2  SF3A3           Pre-mRNA-splicing factor SF3A3, of SF3a compl
        1.8    7.3  15.3        3.2    6.4  15.3    1.3  1  Presenilin      Presenilin
        3.3    7.7  10.0        3.3    7.7   0.2    2.6  2  TEX19           Testis-expressed protein 19
        3.7    6.1  15.9        6.4    5.3  15.9    1.2  1  SWI-SNF_Ssr4    Fungal domain of unknown function (DUF1750)


Domain annotation for each model (and alignments):
>> GREB1  Gene regulated by oestrogen in breast cancer
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.1  19.3    0.0068        20    1146    1271 ..      67     193 ..      10     215 .. 0.60
   2 !   21.5   0.7   9.5e-09   2.8e-05     696     835 ..     485     603 ..     422     633 .. 0.81
   3 ?    1.3   0.2     0.012        36     835     892 ..     796     855 ..     780     877 .. 0.76
   4 !   34.3   0.0   1.3e-12     4e-09     935    1100 ..     997    1184 ..     988    1319 .. 0.85
   5 !   12.7   0.0   4.2e-06     0.012    1515    1607 ..    1413    1500 ..    1400    1504 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.0068
       GREB1 1146 kvekseskdave.sglsskasakselseasaaaasaseeakspkasvtseeeeseeskekekeslsketesqlsleaseqkealdakasskssssss 1241
                  + ++s+  +av+ s++s +as+++++s++ aa+ ++++e+k+pk++ ++e++++e++++k+k++ ++++e++ ++e+ e++++ ++  + +s +s+ 
  EFC38471.1   67 NDQSSTPLSAVStSSISLQASSTPTSSSPPAAKPATKNETKKPKEKDKKEKDKKEKKETKDKKEKKEKKEKKEKKEKEEKDKKRKKVPEKSSEKSKK 163 
                  3444444444441556778888888777667777777777788776555555555544444444444444444333333333333333333334444 PP

       GREB1 1242 ssssassPssscslakavkrPpivllskav 1271
                   +s as+P+ ++ +  ++++ p+v  ++ v
  EFC38471.1  164 KKSDASTPTINTTSITSSSATPTVPSPQKV 193 
                  556677776555544444444444333333 PP

  == domain 2  score: 21.5 bits;  conditional E-value: 9.5e-09
       GREB1 696 GsfekvdflilvPpsevlyqqtvlrlrqsGvlvdlglekesvakqkaekyvvkldseaqaklesllkkakqnpytlfvlvhdhahvdltsavssslsss 794
                   ++++ fl++ P  + l++qt++rl +s +l           + k  +  +k  ++  + +e++  +  ++  tlf+++ d++h+ +t          
  EFC38471.1 485 SLYNHLCFLVCTPDQNTLWHQTMERLERSNILPP---------NTKLSHVSIKYRKDHVQMFEKFRDRIANEKETLFIIIVDECHYAIT---------- 564
                 4488999*************************43.........334445556777778889***************************9.......... PP

       GREB1 795 esslGlvdrllncrevkdapnllvlhvtsfPyalqtqktri 835
                   + G  d+++n +   +  n ++l v++ Py +    + i
  EFC38471.1 565 --KEGAHDKIVNDELALQHNNFFILLVSATPYNVLSVDSNI 603
                 ..67999*************************987777666 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.012
       GREB1 835 ispyneihWpsalsn....dvdlyheekkyfGlseylestksgsslPllrydesfekmvtal 892
                    yn + W + +++     +++ ++ kkyf  ++y++s+k+    Pl+  d  fe++ + +
  EFC38471.1 796 YEEYNVVSWSEVQKRttleRTEQDNQTKKYFSKQDYINSLKQ--EEPLVFKDLEFERVLKKI 855
                 4568889998887651111456777889***********986..5799*******9987655 PP

  == domain 4  score: 34.3 bits;  conditional E-value: 1.3e-12
       GREB1  935 leivqdlinapq....qcpsghGhmvllrvPslalaalakerleevreklglee..rfeiilgnpnseltiek.hfverlkaWrkied......... 1015
                    +++ li++ +    ++ + +G+m +lr+ ++++a   ++ l +  +k++     + +i++ + ++ lt+++ +f++r+k  +k            
  EFC38471.1  997 KTLINTLIESGKipndNSVTLRGKMKILRITTTDFANTVFKLLRSSISKVAASGyiSPDILIDTGENPLTLDQlSFISRMKLAEKVLStedyevfqr 1093
                  4566666666432211344579**********************999999987512569************9868******9988765556999999 PP

       GREB1 1016 ......adWvPrtyleleglPCililsGkdPlGeslPrslkycdlrlidssyltrtaleqelglaaylvskevvreksvgsdllesdaekl 1100
                        ++     y++l  +PCilil  k  +G+++P s+   d+r    s  + +++ qe g  +++v    ++  ++++d + +d  k 
  EFC38471.1 1094 kpsrlsKEKKSLEYINLHNFPCILILVAKGRQGDTFPNSFDCLDMRAKGDSLPNYSSFTQEFGRLCRYVDDSDKKPIALVTDSIYKDLSKC 1184
                  9998888888899*********************************************************999999999999998887665 PP

  == domain 5  score: 12.7 bits;  conditional E-value: 4.2e-06
       GREB1 1515 iPkskekhfvfsqqGkqleslrlPlvsdkspdliksPiftPttgrhehGllnlyhamdGashlhilvvkeyemalykkyW.PnhillvlPsvfn 1607
                  iP sk ++fv s + +++  + lP     +p+ ++s if P+  r   Gl+ l  +m    +  ++vv++ e   y+     + +++ lP ++n
  EFC38471.1 1413 IPSSKMNWFVISSDQQHVTRFLLP----DDPNGVRSWIFVPSWNRSASGLFYL-KSMK-VPYRQVIVVRHSEFKCYRNVLgGDFVIMSLPDIVN 1500
                  9******************99999....589********************88.5676.567899************986257899999*9999 PP

>> DDHD  DDHD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   7.9   0.00047       1.4      70     170 ..      48     163 ..      39     269 .. 0.53
   2 ?    1.8   0.0     0.076   2.3e+02     183     203 ..    1718    1743 ..    1597    1747 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00047
        DDHD  70 sklkPvsiprykrrkllhlelkesltsigaalkqkvsglvssls...........allnrslelaeeesaslaessksherasesskasqeskaaesst 157
                  +l+P  +p+     ++ ++ +++ ++  +a++++  +l +s +           a      + +e+++++++++++++++++++ k+++e+k++++++
  EFC38471.1  48 VDLPPLVVPTNSI--ITPSTPNDQSSTPLSAVSTSSISLQASSTptsssppaakpA------TKNETKKPKEKDKKEKDKKEKKETKDKKEKKEKKEKK 138
                 5677777776655..44566666666666666666666666655555444432221......2222222222222222222222222222222222222 PP

        DDHD 158 asssaksskaee............k 170
                 ++++++++++++            k
  EFC38471.1 139 EKKEKEEKDKKRkkvpekssekskK 163
                 2222221111112223233332220 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.076
        DDHD  183 g..RiDYaLq.egalea..eylsava 203 
                  +  RiDY+L+ + ++e+  e++++++
  EFC38471.1 1718 NplRIDYVLPvPTMYEIeeEIFNTIS 1743
                  235***********999888888875 PP

>> SF3A3  Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   1.8   0.00037       1.1      11      73 ..     900     981 ..     891     983 .. 0.80
   2 ?   -3.2   0.1       4.2   1.3e+04      47      72 ..    1293    1317 ..    1249    1319 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00037
       SF3A3  11 ylDLnelyeeylnlkeikldYlqYLesfdkf.....................seip.kkqkkskeYkeYlkeLleYLesfikrtq 73 
                  lD++  ++ y+++ +  l Yl+YL    ++                     +e + + +kk+++ ++ +++LleYL++ +k ++
  EFC38471.1 900 ALDIEPKHKIYVEICK--LIYLAYLCAK-HLkmddvlenqefddedddydilDETKkTVKKKKEDLEKKIQHLLEYLKNKFKPKN 981
                 699**********996..99*****543.33446668999999999999888555535566688999***********9988665 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 4.2
       SF3A3   47 kqkkskeYkeYlkeLleYLesfikrt 72  
                     k ++ ++++++  +Y ++f+++ 
  EFC38471.1 1293 V-HKLSRIESFMTSSNHYWSKFMEKL 1317
                  3.333566778888888888888775 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4  15.3    0.0011       3.2     234     300 ..     104     167 ..      71     243 .. 0.48

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0011
  Presenilin 234 eseeeeeaekkkeeasesskeeeseees.seksaqsseseeeseeesseaessaeesseekeseesse 300
                 +++++ ++++kke++++++ke+++++e+ ++k++++++++ee+++++++++++++e+s++k    +s+
  EFC38471.1 104 NETKKPKEKDKKEKDKKEKKETKDKKEKkEKKEKKEKKEKEEKDKKRKKVPEKSSEKSKKK----KSD 167
                 1111111111111111111111111111011111111111111111111111111111111....111 PP

>> TEX19  Testis-expressed protein 19
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   4.7     0.054   1.6e+02      51     130 ..     112     194 ..     101     203 .. 0.59
   2 ?    7.7   0.2    0.0011       3.3      36      76 ..     920     960 ..     906     980 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.054
       TEX19  51 ledWede.dwdaelmelseagseqeaspg.velswgqgslqvaqgvsea.lgsgalasapeeseevgldshfvPtelePqeav 130
                  ++ e++ ++ +e+ ++ e++ ++e++ + ++++  + + +v++++se+   + + as+p+   +   +s + Pt  +Pq++v
  EFC38471.1 112 KDKKEKDkKEKKETKDKKEKKEKKEKKEKkEKEEKDKKRKKVPEKSSEKsKKKKSDASTPTINTTSITSSSATPTVPSPQKVV 194
                 44444330334455555555444444443233334555555555555541445566888877666667889999999999987 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0011
       TEX19  36 acfkaafldlkelleledWededwdaelmelseagseqeas 76 
                 a   a  l++ ++le ++++ded d +++++++++ +++++
  EFC38471.1 920 AYLCAKHLKMDDVLENQEFDDEDDDYDILDETKKTVKKKKE 960
                 33446689999*******************98876655443 PP

>> SWI-SNF_Ssr4  Fungal domain of unknown function (DUF1750)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3  15.9    0.0021       6.4     513     653 ..      64     193 ..      33     232 .. 0.50

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0021
  SWI-SNF_Ssr4 513 stglsststpvnnfptpqeqlsaaqsaaatpasanvaspapaqata...qeaqsaesededvemggtee..keketetapdaatesgdwVvvpkggk 604
                   st   + stp++ ++t++ +l+a  s+++t +s  +a+pa++++t+   ++ +++++++e  e ++ +e  ++ke++++++++++ +    vp++ +
    EFC38471.1  64 STPNDQSSTPLSAVSTSSISLQA--SSTPTSSSPPAAKPATKNETKkpkEKDKKEKDKKEKKETKDKKEkkEKKEKKEKKEKEEKDKKRKKVPEKSS 158
                   56677889999999999777777..777777666666676666655222111111111222222222221112222222222222222233333222 PP

  SWI-SNF_Ssr4 605 spseaaakaaaeasaeagaaaaekaakesaakateaagkeattpaakaa 653
                   ++s++++ + a++++ +             +++ + ++++ t p++++ 
    EFC38471.1 159 EKSKKKK-SDASTPTIN-------------TTSITSSSATPTVPSPQKV 193
                   2222111.111122111.............2222222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1847 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2931  (0.163478); expected 358.6 (0.02)
Passed bias filter:                      713  (0.039768); expected 358.6 (0.02)
Passed Vit filter:                       304  (0.0169558); expected 17.9 (0.001)
Passed Fwd filter:                        60  (0.00334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.76u 0.40s 00:00:02.16 Elapsed: 00:00:00.58
# Mc/sec: 9578.51
//
Query:       EFC38472.1  [L=483]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.027   14.4   0.7      0.027   14.4   0.7    2.3  2  LcrG            LcrG protein


Domain annotation for each model (and alignments):
>> LcrG  LcrG protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1      0.55   9.8e+03      59      71 ..     153     165 ..     141     172 .. 0.61
   2 ?   14.4   0.7   1.5e-06     0.027       8      67 ..     286     345 ..     278     353 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.55
        LcrG  59 LleevkRrRsrqp 71 
                  l+e+k+++++ +
  EFC38472.1 153 QLKELKKQKKQIK 165
                 4566666665544 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.5e-06
        LcrG   8 tlkaaelairdsdeRakllqelleglGlapeageklfggleaelvkaaeqeLleevkRrR 67 
                  lk+ el i++s +  +l++e  + l l+pe+ + ++ g+++  ++ a + +l e+k r+
  EFC38472.1 286 KLKEKELKIEQSKDDVQLFEENGQALVLKPEIKKIFIDGNNMFFMNRAMRHILLELKNRK 345
                 58999**************************************************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3421  (0.190808); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.82u 0.37s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 2764.30
//
Query:       EFC38473.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       902  (0.0503096); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1639.35
//
Query:       EFC38474.1  [L=1232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.68    9.8   4.8        1.6    8.7   4.8    1.6  1  LPAM_2       Prokaryotic lipoprotein-attachment site


Domain annotation for each model (and alignments):
>> LPAM_2  Prokaryotic lipoprotein-attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   4.8   8.7e-05       1.6       1      16 [.       7      22 ..       7      23 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 8.7e-05
      LPAM_2  1 lllllallllLaGCGq 16
                ll l++lll+LaGCG 
  EFC38474.1  7 LLILVVLLLALAGCGN 22
                799************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       621  (0.0346366); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.37s 00:00:01.17 Elapsed: 00:00:00.53
# Mc/sec: 7008.47
//
Query:       EFC38475.1  [L=559]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.8e-16   58.4  16.8    2.9e-15   56.3  16.8    2.0  1  CytochromB561_N  Cytochrome B561, N terminal


Domain annotation for each model (and alignments):
>> CytochromB561_N  Cytochrome B561, N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.3  16.8   1.6e-19   2.9e-15     212     569 ..      63     556 ..      28     557 .. 0.73

  Alignments for each domain:
  == domain 1  score: 56.3 bits;  conditional E-value: 1.6e-19
  CytochromB561_N 212 vqsSeeidsaksspwsrkraksakeirtekqLerflaevdekitesafgkaspsnvagslnrSgsarstplrsvrmspgs..qkkttppkkgeg 303
                      +  S+++ +++++ ++++ +++++  ++ +++   +++  + +++   + +s s+++  +n S +++++  +s +++p +  ++++  p  g +
       EFC38475.1  63 MDESNNM-NMNTNMNINN-MNINNMNMNTNMMGGVYNNNMMMMNNMMYDPSSISTSSYLYNSSLQEQQQEQQSLQLQPTQvaLQFNINPSIGLS 154
                      3333322.2233333333.344444444455555555555434444444444455555788888888888888888888777788888888888 PP

  CytochromB561_N 304 dlPskmsmeeaieafeelgiYp........................................qieqwrdrLRqWissvlLnpLvekietshkqv 357
                       + s +   e   a  + +i +                                         +++w +++R+W+   +L p  ++i++++ q+
       EFC38475.1 155 VFDSNSGKLEYRRA-PSNQINEdfilnheqlnqqlnqqysgnalllgeqasqalemlnlttfTVNNWSENMRKWMIYGVLIPTIKEIDSINLQM 247
                      88777777776333.233333357777888888999999999999999999999999999999******************************* PP

  CytochromB561_N 358 kqa.aak..........................pdlqlgedgllrlkraalvqaldtslqspqlplLiPflqe..................... 403
                      +++  ++                          p+ +  ++  l+  +a+lv ++d ++qs +l+  i  +                       
       EFC38475.1 248 HKTiQFNcdfkgydsfnpldispeyqhsipnsiPHTEDTSKFTLKYVLATLVTQIDQQQQSNNLNGGIGGVGGgfnsgfgfsngfnqsqpqtnq 341
                      987345699*********************9996666666666778999999999998888888888877777999999999999999999999 PP

  CytochromB561_N 404 .................................svnqdYlVqRIkeLaegtclknYe..ynsggevtdkknkkW.deeLPtDsalllyLFcayL 461
                                                           +Y++ RI+ +++g++ k      + ++e     +  + +e  PtD  ++  LFc ++
       EFC38475.1 342 qknvefgnllrrrlrlerylsipnlnlfdstdkIACRKYVIDRIRSMSKGQFEKPNSrpMLNNSE-----QFLYeQEIYPTDEEIIVNLFCKFM 430
                      9999999999999999************988876778***************9853311333444.....333304557*************** PP

  CytochromB561_N 462 dsqL.....hPkwknplflGvlppkerFpekYvvvvskkp............................avkhpgacilavgkqspPkfalvwdk 522
                      d  L       ++ n  +   + +k+                                          +v  +  ++l  +k s  +++   d 
       EFC38475.1 431 DFTLdshghSSQFSNKYYCDQNIEKK-------------EnphnlfrnrnmlapgvanamkkkrgldkQVPVKKGLYLCKSKVSISHYNVEDDG 511
                      *8886633212333333333332222.............1233333333333345556777779998888888899****************** PP

  CytochromB561_N 523 klqnslqgrtnLfdsillllhrikteygGvvrginLGsSglnilpvl 569
                      +l+ +  gr+n+f++++++lh i+t+y+G+++ + L+   ln+ +v+
       EFC38475.1 512 NLYECQPGRNNVFYALVIFLHLINTKYDGYIDTVALSD--LNLSQVI 556
                      *********************************99965..6666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (559 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1327  (0.0740142); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.74u 0.35s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 3062.78
//
Query:       EFC38476.1  [L=994]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.017   15.7   3.0      0.017   15.7   3.0    5.3  4  Secretin_N_2  Secretin N-terminal domain


Domain annotation for each model (and alignments):
>> Secretin_N_2  Secretin N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -17.1  27.6         1   1.8e+04      23      62 ..     319     359 ..     270     371 .. 0.56
   2 ?    9.2   8.2   9.7e-05       1.7      31      62 ..     506     544 ..     494     558 .. 0.53
   3 ?   15.7   3.0   9.4e-07     0.017      20      58 ..     608     642 ..     593     670 .. 0.56
   4 ?    2.8  13.6    0.0097   1.7e+02      32      55 ..     921     944 ..     909     961 .. 0.40

  Alignments for each domain:
  == domain 1  score: -17.1 bits;  conditional E-value: 1
  Secretin_N_2  23 sGsvsssgssssssssssss.sgsssssssssnsssgtkie 62 
                   s++ +  +ss+s ++s+ +  + + s++++++n++++ +++
    EFC38476.1 319 SSTPTPLNSSNSPGGSAANItNTNTSTTTTNTNTNNTNNTT 359
                   33333333333333333322233333333333333333333 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 9.7e-05
  Secretin_N_2  31 ssssssssssss.sgsssssssssnss......sgtkie 62 
                   +ss++++++s + ++ss+s++s++n++       +++i 
    EFC38476.1 506 NSSNNNNNTSINnNNSSNSNNSNNNENylkmnlGTAFID 544
                   222222222222144444444444444555555555554 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 9.4e-07
  Secretin_N_2  20 svtsGsvsssgsssssssssssssgsssssssssnsssg 58 
                   +v+s+s s +++++++++  +++   ++ ++ ++n+++g
    EFC38476.1 608 KVSSSSSSYNDNNNNNNNEYNNN---NEYNN-NNNNNNG 642
                   44444444444444444443322...21122.2222222 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.0097
  Secretin_N_2  32 ssssssssssssgsssssssssns 55 
                   +s++ ++++++s+s++s++++++s
    EFC38476.1 921 NSNNINNNNNNSNSNNSNNNNNTS 944
                   222222211111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (994 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1628  (0.0908026); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.88u 0.32s 00:00:01.20 Elapsed: 00:00:00.52
# Mc/sec: 5774.72
//
Query:       EFC38477.1  [L=782]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (782 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1471  (0.0820458); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.80u 0.35s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 4280.83
//
Query:       EFC38478.1  [L=1097]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.8e-07   31.2  13.6     0.0081   16.3   0.2    6.9  7  ASH           Abnormal spindle-like microcephaly-assoc'd, ASP
    0.00012   22.1   0.2       0.33   11.1   0.1    3.4  4  PapD-like     Flagellar-associated PapD-like
     0.0077   16.5   4.4      0.026   14.8   4.4    1.9  1  ABC_tran_CTD  ABC transporter C-terminal domain
  ------ inclusion threshold ------
       0.09   12.1   3.8      0.057   12.8   1.2    1.9  2  IMD           IRSp53/MIM homology domain
        0.1   12.8   0.0        0.1   12.8   0.0    5.9  7  TMEM131_like  Transmembrane protein 131-like
       0.58   10.5   3.5        2.5    8.5   3.5    2.1  1  CLZ           C-terminal leucine zipper domain of cyclic nucl


Domain annotation for each model (and alignments):
>> ASH  Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.2   2.7e-06    0.0081      12      91 ..     157     234 ..     152     241 .. 0.88
   2 !    5.2   0.5    0.0081        24      12      59 ..     274     322 ..     265     327 .. 0.84
   3 ?    4.1   0.0     0.018        54      42      89 ..     594     640 ..     586     647 .. 0.81
   4 ?    1.1   0.0      0.16   4.7e+02      39      70 ..     700     731 ..     674     735 .. 0.77
   5 !    6.8   0.0    0.0025       7.6      11      89 ..     736     824 ..     731     827 .. 0.80
   6 ?   -2.1   0.1       1.5   4.6e+03       8      37 ..     847     878 ..     845     899 .. 0.76
   7 ?   -2.7   0.0       2.4   7.3e+03      38      73 ..     986    1015 ..     968    1019 .. 0.50

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.7e-06
                 EEEEE-----EEEEEEE-EEESS-SS--EEEEEEEE--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXX CS
         ASH  12 pfvsFgdvkvGssaerlLtveNpseepaevkvskvpaaekgfsveetelevqpgesvtltvtwtPteega.vrevLqflvn 91 
                  +++Fgd ++G ++ +++t+ N s+ ++++ v+ ++   k +++++++  ++p++ + +t+ ++P    +  r+ ++++++
  EFC38478.1 157 SNIKFGDSTIGDIKFASVTIYNRSDLATRISVQFTS---KVITCKTKSAIISPHKFIRITFRLSPRRVNPnYRKQITIVNE 234
                 689**********************99888887766...9*************************9987768888888754 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0081
                 EEEEE-----EEEEEEE-EEESS-SS-.-EEEEEEEE--XXXXXXXXXX CS
         ASH  12 pfvsFgdvkvGssaerlLtveNpseep.aevkvskvpaaekgfsveete 59 
                  +++Fg v+++ +   + +++N s+ep +  + s +p++   f+v+ t+
  EFC38478.1 274 KSINFGVVALNGISLSKFQISNISDEPiTLKFKSSSPNEISTFKVKRTT 322
                 579************************7777777888888899998776 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.018
                 EEEEEE--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
         ASH  42 kvskvpaaekgfsveetelevqpgesvtltvtwtPteegavrevLqfl 89 
                 k+s ++ ++ +f ++ +++ + p +s+ + +t+ P+++ ++   +++ 
  EFC38478.1 594 KLSNSI-DDLKFLIPCDTISIGPTSSTEIYITYRPKSTNSKFTSINLN 640
                 667777.788999999********************998776666665 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.16
                 -EEEEEEEE--XXXXXXXXXXXXXXXXXXXXX CS
         ASH  39 aevkvskvpaaekgfsveetelevqpgesvtl 70 
                 +e++  +++++++ f+++++el++q + ++++
  EFC38478.1 700 IELIDYDTNNEQTDFTLPPRELTIQSKICQSM 731
                 66777778889**************9977766 PP

  == domain 5  score: 6.8 bits;  conditional E-value: 0.0025
                 -EEEEE-----EEEEEEE-EEESS-SS-..-EEEEEEEE--XXXXXXXXXX.........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
         ASH  11 kpfvsFgdvkvGssaerlLtveNpseep..aevkvskvpaaekgfsveete.........levqpgesvtltvtwtPteegavrevLqfl 89 
                 + +++Fg+++  + +++++t++N+se p   ++k s ++ a++ +++  +            v p +s  +++ ++P+  g  +e+L+f 
  EFC38478.1 736 QKNINFGSITNVEDRKKTITISNGSEVPllFRIKRSGSI-ASNDIKILDMLddslnlswcGLVRPYGSRDIQLYFKPSLPGVFNETLTFE 824
                 57899**999999**************977789999999.55555543322244556667889999999999999999999999999995 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 1.5
                 TB--.EEEEE-----EEEE.EEE-EEESS-SS CS
         ASH   8 fsrk.pfvsFgdvkvGssa.erlLtveNpsee 37 
                 f+ k + ++Fg++ ++++  +++++v+N s+ 
  EFC38478.1 847 FTLKsNDINFGNILLNQFSlSKKIVVTNMSKN 878
                 55555889999999999874677999988775 PP

  == domain 7  score: -2.7 bits;  conditional E-value: 2.4
                  -.-EEEEEEEE--XXXXXXXXXXXXXXXXXXXXXXXX CS
         ASH   38 p.aevkvskvpaaekgfsveetelevqpgesvtltvt 73  
                     + k +k+ +   +       + ++p  s++++++
  EFC38478.1  986 GkKQRKFKKIEENGIR-------FSIPPRMSQVINLK 1015
                  4444444444444444.......55555555555555 PP

>> PapD-like  Flagellar-associated PapD-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.1   0.00011      0.33       4      93 ..     152     238 ..     149     247 .. 0.88
   2 ?   -4.0   0.0       5.6   1.7e+04      11      36 ..     276     301 ..     274     315 .. 0.76
   3 !    6.7   0.0    0.0027       8.1       4      44 ..     732     772 ..     730     781 .. 0.89
   4 ?   -1.5   0.0      0.95   2.8e+03       4      34 ..     847     878 ..     846     900 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00011
   PapD-like   4 levsPakveFGkvlpgnryvltvellnvstvpcRyrvrlpavvkkllsveYkrqFvaPGltvklkvelsgaqplGemdselsvvheggiv 93 
                 +evsP++++FG  + g    ++v++ n s   +R  v++++   k+++ + k   ++P   +++   ls  +   + + ++++v e + +
  EFC38478.1 152 IEVSPSNIKFGDSTIGDIKFASVTIYNRSDLATRISVQFTS---KVITCKTKSAIISPHKFIRITFRLSPRRVNPNYRKQITIVNESNKL 238
                 79***********************************9988...8999999999999999999999999888888899999999887655 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 5.6
   PapD-like  11 veFGkvlpgnryvltvellnvstvpc 36 
                 ++FG v  +   +   ++ n+s  p 
  EFC38478.1 276 INFGVVALNGISLSKFQISNISDEPI 301
                 78999988888888888999988775 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0027
   PapD-like   4 levsPakveFGkvlpgnryvltvellnvstvpcRyrvrlpa 44 
                 +e+  ++++FG +++ +   +t+++ n s vp  +r++ + 
  EFC38478.1 732 MEIAQKNINFGSITNVEDRKKTITISNGSEVPLLFRIKRSG 772
                 6888899*****************************98765 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 0.95
   PapD-like   4 levsPakveFGkvlpgn.ryvltvellnvstv 34 
                 + ++ + ++FG++l ++    + ++++n+s  
  EFC38478.1 847 FTLKSNDINFGNILLNQfSLSKKIVVTNMSKN 878
                 56677889999987554156677888888865 PP

>> ABC_tran_CTD  ABC transporter C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   4.4   8.6e-06     0.026       9      58 ..     901     952 ..     895     953 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 8.6e-06
  ABC_tran_CTD   9 elee..leaeIeaLEeeiaeleaeladpelysdpeklaelsaeleeleaeLe 58 
                   ele+     eIe+LE+e+++le +       +++ k+++l+++++e+++eL+
    EFC38478.1 901 ELEQvsQSTEIEKLEAELEKLEHKYRICVRKNKSSKIKKLTERINEIKKELN 952
                   5665223458*************77766433566****************95 PP

>> IMD  IRSp53/MIM homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1      0.64   1.9e+03      79     111 ..     457     489 ..     454     494 .. 0.85
   2 ?   12.8   1.2   1.9e-05     0.057     106     158 ..     899     952 ..     874     958 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.64
                 HHHHHTTHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         IMD  79 kalhdsLlnpleekveedkkvlnqldkdyakEy 111
                 k l+d+  n l++ +  d k+++ql+   ++Ey
  EFC38478.1 457 KKLKDESSNTLKRSTSMDDKFISQLNDPTNLEY 489
                 56778888999999***********99999998 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.9e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHTTHCC.CS-CHHHHHHHHHHHHHHHHHHHH CS
         IMD 106 dyakEykkkraelkKkssellklqkKakk.gkddlkvqldelledvndkyllle 158
                 +y++E+ ++  e++K ++el kl++K +   ++++  ++++l e +n+ + +l+
  EFC38478.1 899 EYELEQVSQSTEIEKLEAELEKLEHKYRIcVRKNKSSKIKKLTERINEIKKELN 952
                 89************************998567888889999******9988874 PP

>> TMEM131_like  Transmembrane protein 131-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   3.5e-05       0.1       2      66 ..     153     214 ..     152     224 .. 0.71
   2 ?    1.0   0.5      0.17   5.2e+02      21      52 ..     227     258 ..     219     266 .. 0.82
   3 ?   -1.8   0.0       1.3   3.9e+03       4      26 ..     483     505 ..     483     508 .. 0.89
   4 ?   -3.3   0.0       3.7   1.1e+04      20      41 ..     631     652 ..     625     657 .. 0.76
   5 ?   -1.9   0.0       1.3     4e+03      56      82 ..     797     823 ..     776     824 .. 0.84
   6 ?    0.4   0.1      0.27   8.1e+02      20      39 ..     867     886 ..     848     903 .. 0.69
   7 ?   -2.7   0.2       2.5   7.5e+03      26      48 ..    1041    1064 ..    1036    1068 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.5e-05
  TMEM131_like   2 eisPpeLdFgesslgkaasrtvtvvNkhkkeklkllsvtsdsiefqssffeevvlpPggntslkv 66 
                   e+sP++++Fg s++g+ +++ vt++N++   +l     ++ + +   +  +++ + P++ +++++
    EFC38478.1 153 EVSPSNIKFGDSTIGDIKFASVTIYNRS---DLATRISVQFTSKVITCKTKSAIISPHKFIRITF 214
                   789***********************44...3333333333344556677777777777766665 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.17
  TMEM131_like  21 rtvtvvNkhkkeklkllsvtsdsiefqssffe 52 
                   +++t+vN+++k + ++ +v s++i+ +  +f+
    EFC38478.1 227 KQITIVNESNKLNEQIIEVESNNIDRNMLNFH 258
                   689********999999999999986655554 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.3
  TMEM131_like   4 sPpeLdFgesslgkaasrtvtvv 26 
                   +P++L++ +s + +++ +++ ++
    EFC38478.1 483 DPTNLEYLQSIMTQPNVSKLNIH 505
                   599************99998875 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 3.7
  TMEM131_like  20 srtvtvvNkhkkeklkllsvts 41 
                   +++ t +N ++++ l l+s +s
    EFC38478.1 631 NSKFTSINLNNSSPLSLYSDFS 652
                   5667778999999999998665 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 1.3
  TMEM131_like  56 lpPggntslkvvFLPrelGaseaslkl 82 
                   ++P g++ +++ F P+  G+++ +l++
    EFC38478.1 797 VRPYGSRDIQLYFKPSLPGVFNETLTF 823
                   899************999999888865 PP

  == domain 6  score: 0.4 bits;  conditional E-value: 0.27
  TMEM131_like  20 srtvtvvNkhkkeklkllsv 39 
                   s++++v N++k++ ++ +++
    EFC38478.1 867 SKKIVVTNMSKNRRIFETQI 886
                   6899********99876555 PP

  == domain 7  score: -2.7 bits;  conditional E-value: 2.5
  TMEM131_like   26 vNkhkkeklkllsvtsdsie.fqs 48  
                    +N+++++ ++l s++  +i+ fq+
    EFC38478.1 1041 RNTDEQKMVTLSSIVHFDIKsFQN 1064
                    599999999999998755543664 PP

>> CLZ  C-terminal leucine zipper domain of cyclic nucleotide-gated channels
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   3.5   0.00083       2.5      25      70 ..     903     949 ..     897     950 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00083
         CLZ  25 eqkeleekverLessLeaLqtrlarLlaeyessq.rkLkqRitkLEk 70 
                 eq +  + +e+Le++Le L+ +++  +++ +ss+ +kL++Ri+++ k
  EFC38478.1 903 EQVSQSTEIEKLEAELEKLEHKYRICVRKNKSSKiKKLTERINEIKK 949
                 78888999*****************999998887589*****99865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1097 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2094  (0.116794); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.99u 0.35s 00:00:01.34 Elapsed: 00:00:00.57
# Mc/sec: 5842.61
//
Query:       EFC38479.1  [L=139]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0044   17.2   1.9        1.3    9.3   0.0    2.4  2  TMEM131_like  Transmembrane protein 131-like
  ------ inclusion threshold ------
       0.12   12.9  14.1       0.26   11.9  14.1    1.6  1  Secretin_N_2  Secretin N-terminal domain


Domain annotation for each model (and alignments):
>> TMEM131_like  Transmembrane protein 131-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0   0.00015       1.3      59      82 ..       8      31 ..       2      33 .. 0.84
   2 !    7.0   0.7    0.0008       7.2       7      42 ..      79     115 ..      76     130 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00015
  TMEM131_like 59 ggntslkvvFLPrelGaseaslkl 82
                  + +++++v+F+P+ +G+++ ++ l
    EFC38479.1  8 HSSMRVNVIFIPKIIGEINLNVNL 31
                  67889***********99887766 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0008
  TMEM131_like   7 eLdFgesslgkaasrtvtvvNkhkkeklkll.svtsd 42 
                   +LdFge   g+ +++ +t++N++ + ++ +   +ts+
    EFC38479.1  79 KLDFGEFFKGQTSFKLITLRNQSSTDTFDVFfGLTSN 115
                   79**********************9999885133333 PP

>> Secretin_N_2  Secretin N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9  14.1   2.8e-05      0.26       8      50 ..      96     137 ..      90     139 .] 0.69

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.8e-05
  Secretin_N_2   8 ylamkrsGlsntsvtsGsvsssgsssssssssssssgssssss 50 
                    l  ++s + + +v +G +s+s++s++++s++++ss+ss++++
    EFC38479.1  96 TLRNQSS-TDTFDVFFGLTSNSNNSNNNNSNNNNSSNSSNNNN 137
                   4444443.4556999******9999999999996666666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (139 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       878  (0.0489709); expected 358.6 (0.02)
Passed bias filter:                      232  (0.0129399); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.51
# Mc/sec: 821.30
//
Query:       EFC38480.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.6e-30  105.2   0.0      4e-30  104.6   0.0    1.2  1  CRAL_TRIO    CRAL/TRIO domain
  ------ inclusion threshold ------
      0.067   13.4   0.2        0.3   11.3   0.0    2.2  2  CRAL_TRIO_N  CRAL/TRIO, N-terminal domain


Domain annotation for each model (and alignments):
>> CRAL_TRIO  CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.6   0.0   4.5e-34     4e-30      10     159 .]     105     254 ..     101     254 .. 0.94

  Alignments for each domain:
  == domain 1  score: 104.6 bits;  conditional E-value: 4.5e-34
   CRAL_TRIO  10 gihgrDkegrpvlylrlgrfdpkkls.leelvralvlvlerllkelee..dgqvegvtvviDlkglslskmlwkpisllkkilkilqdnyperlgkili 105
                 ++ g Dkeg p+l l +++f p +l+  e + +++ +vle++++el    +g+ e+++vviD+kg+sls ++   ++l k+il + q+++perl+ + +
  EFC38480.1 105 CFMGSDKEGCPCLCLAISNFVPGTLQpYELIEELVGFVLEVAFHELRLqtGGKLEKFVVVIDYKGWSLSCVD---TKLDKSILGTCQNYFPERLKLATL 200
                 67899******************99945556667779******98877889*********************...99********************** PP

   CRAL_TRIO 106 vnaPklfkfafklvkpfldektreKikfvspsnteatlekyidpeqlpkelGGt 159
                  +aP+lf++a+ ++k fldekt+eKi+fv +s++ ++l+k +d + + k++GG+
  EFC38480.1 201 MRAPWLFSTAWAVAKLFLDEKTTEKISFVYESDMLSELRKNFDDSTILKKFGGQ 254
                 *****************************************************6 PP

>> CRAL_TRIO_N  CRAL/TRIO, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   3.4e-05       0.3      27      50 ..      48      71 ..      14      75 .. 0.83
   2 ?   -1.3   0.2      0.28   2.5e+03       1       1 [.     257     257 ..     220     280 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3.4e-05
  CRAL_TRIO_N 27 edhddaclLRfLRArkwdvekAik 50
                 e +dd++ +R LRA+  +v+k+i 
   EFC38480.1 48 EVNDDVFYVRWLRAYSGNVDKTIS 71
                 468999***************996 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.28
  CRAL_TRIO_N   1 a 1  
                  +
   EFC38480.1 257 K 257
                  1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       555  (0.0309554); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 1870.52
//
Query:       EFC38481.1  [L=355]
Description: guanine nucleotide-binding protein G(i) alpha-1 subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.9e-94  315.7  12.4    4.7e-94  315.4  12.4    1.0  1  G-alpha         G-protein alpha subunit
    5.3e-16   58.6   0.4    1.4e-10   40.9   0.2    3.1  2  Arf             ADP-ribosylation factor family
    8.4e-06   26.0   0.1      0.059   13.6   0.1    2.7  2  Roc             Ras of Complex, Roc, domain of DAPkinase
    4.7e-05   23.0   1.3     0.0097   15.5   0.3    2.5  2  Ras             Ras family
     0.0025   17.9   0.1          3    8.0   0.1    2.6  2  MMR_HSR1        50S ribosome-binding GTPase
     0.0065   15.9   4.4       0.17   11.2   0.2    2.7  2  Gtr1_RagA       Gtr1/RagA G protein conserved region
     0.0092   15.7   0.7      0.087   12.5   0.1    2.3  2  DNA_pol_A_exo1  3'-5' exonuclease
  ------ inclusion threshold ------
       0.04   13.7   2.7        1.5    8.5   2.7    2.6  1  ATP_bind_1      Conserved hypothetical ATP binding protein
       0.11   12.0   0.1        1.5    8.3   0.0    2.3  2  FeoB_N          Ferrous iron transport protein B


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  315.4  12.4   2.4e-97   4.7e-94       8     352 ..      22     346 ..       5     348 .. 0.89

  Alignments for each domain:
  == domain 1  score: 315.4 bits;  conditional E-value: 2.4e-97
                 XXXXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCH CS
     G-alpha   8 dkslkaerkarkkkrevkllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkvea 106
                 d +++++ + ++ + +vkllllG++eSGKsT++kq++         +e++  ++ +++n+v+s+  ++++l++l+ e+    +++el++ +++++++++
  EFC38481.1  22 D-EMNENADPNSGNYDVKLLLLGSGESGKSTFFKQVQ---------NERRRVKNTVHFNVVSSMAVMCQKLKELNLEF----SSEELSKCAERVLQLSK 106
                 2.23333333344789*********************.........346889*********************98888....67777777777777777 PP

                 HHH............HHCCHHC-HCHHHHHHHHCCSHHHHHHHC.CGCCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TE CS
     G-alpha 107 sliaklssateee..qeiefnpraevgedikaLwndpgiqelye.rrnkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdskl 202
                 +  a+++s+t+ +  + ++ ++  e+++di +Lw+d +iq++++ +rn++++ d+aeyF+++l+ i ++dY+p+++D+l++r+kt+Gi e++f+ + +l
  EFC38481.1 107 NR-AFMTSTTSVKggDRNFYTD--EIANDIYQLWKDSTIQKVFQnNRNDVHVFDGAEYFFERLDIIRKNDYIPSEEDLLYCRQKTIGIVEVSFDHE-SL 201
                 64.4556666666789999999..********************666************************************************9.** PP

                 EEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGGCCTT--H. CS
     G-alpha 203 efrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgklskyfpsyegr 301
                 +f ++dvgGqrserkkWv++f++v+a++++ sl+++d  +yed++ nr+++sl++F+ +cn  ++k+tpii++lnK+Di+++Kl+   ++++f++y+g 
  EFC38481.1 202 KFSLFDVGGQRSERKKWVNCFEGVSAVVYVSSLADYDLKMYEDDSLNRMDDSLTVFEGLCN-GFFKETPIIIVLNKTDIFKKKLEVHGIEQCFKDYNG- 298
                 ************************************************************9.6**********************************9. PP

                 CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHHHH CS
     G-alpha 302 kndlesvlkylrnkFeeihkeksnnrrkiythftsatdtkevqkviesvrd 352
                 ++d+++ ++++rnkF++++k    ++++i +h  +at t++v+kv+e++++
  EFC38481.1 299 SQDYDESVQFIRNKFLSLNK---FDEQRIWIHECCATSTDDVRKVFEQIKH 346
                 9*****************76...45558********************976 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.0   1.6e-05     0.032      12      52 ..      34      73 ..      27      89 .. 0.83
   2 !   40.9   0.2     7e-14   1.4e-10      45     174 ..     188     347 ..     178     348 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.6e-05
                TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEE CS
         Arf 12 kkelrilllGLDnaGKtTilkklkleelvttvPTigfnvee 52
                + ++++lllG  ++GK+T  k++++e+  +++ T++fnv +
  EFC38481.1 34 NYDVKLLLLGSGESGKSTFFKQVQNER-RRVKNTVHFNVVS 73
                5689*****************998876.56889*****854 PP

  == domain 2  score: 40.9 bits;  conditional E-value: 7e-14
                 SSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT..........THHHHHHHHHHHCTSGCCTTSEEEEEEE-TTS.TTSS- CS
         Arf  45 TigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre..........RleeakeeLkalleeeelkevallvlaNKqDl.peals 132
                 Tig    +  ++ lkf+++DvGGq++ R+ W n fe + av++v   ad +          R++++ + ++ l +    ke +++++ NK D+ ++ l+
  EFC38481.1 188 TIGIVEVSFDHESLKFSLFDVGGQRSERKKWVNCFEGVSAVVYVSSLADYDlkmyeddslnRMDDSLTVFEGLCN-GFFKETPIIIVLNKTDIfKKKLE 285
                 777777788899********************************8777755322333333366666665555554.45789***********8355677 PP

                 HHHHHHHTTGGG................SS....SSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 133 eeelrellglee................lk....gkrkleiqkcsavkgeglkeglewlses 174
                  + +++  + ++                l+     ++++ i +c+a++ +++ + +e++ ++
  EFC38481.1 286 VHGIEQCFKDYNgsqdydesvqfirnkfLSlnkfDEQRIWIHECCATSTDDVRKVFEQIKHQ 347
                 88898888888888889999888666662255777889999999999999999999988765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.1     3e-05     0.059       1      42 [.      38      77 ..      38      93 .. 0.73
   2 !    9.6   0.0   0.00052         1      47     119 ..     192     278 ..     172     279 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3e-05
                EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECG CS
         Roc  1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevt 42
                K++l+G +++GK++++k++++++ + k  +t+  +++++ ++
  EFC38481.1 38 KLLLLGSGESGKSTFFKQVQNERRRVK--NTVHFNVVSSMAV 77
                89******************9888655..5666666665443 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00052
                 CTTBTTTTCEEEEEEEE-SGGCTTT.T-HHHHCTSCEEEEE....EE.....GHHHHCHHHHHHHHHHHCS....SS-EEEEEE-TT CS
         Roc  47 vendkkvkkvklniWDtaGqerfrs.lhplylreaalailv....yd.....srssenlkeWlkelkkvag....kspvilvgnkiD 119
                 ve + + +++k++++D++Gq   r+   +++   +a++ +     yd     ++s +++++ l+ ++  ++    ++p+i+v nk+D
  EFC38481.1 192 VEVSFDHESLKFSLFDVGGQRSERKkWVNCFEGVSAVVYVSsladYDlkmyeDDSLNRMDDSLTVFEGLCNgffkETPIIIVLNKTD 278
                 34444567899*********9887637788877666554422323556554322334556666666655433332889*******99 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   0.0     0.004         8       1      42 [.      38      77 ..      38      89 .. 0.72
   2 !   15.5   0.3   4.9e-06    0.0097      39     161 ..     192     349 ..     183     350 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.004
                EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEE CS
         Ras  1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeie 42
                Kl+l+G++  GK+++  +  ++  +++ ++T++++  ++   
  EFC38481.1 38 KLLLLGSGESGKSTFFKQVQNE--RRRVKNTVHFNVVSSMAV 77
                89************99886555..456778887776655544 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 4.9e-06
                 EEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEE.....EETT..BHHHHHTHHHHHHHHHHHST...TTSEEEEEEETTTGGG......... CS
         Ras  39 keievdgkevkleiwDTAGqeefkslrelyyrdaegillv.....ydit..sresfenvkkwveeikrvae...envpivLvGnKvDlee......... 118
                  e+++d++++k++++D  Gq   ++   ++++++++++ v     yd++  + +s++++++ ++ ++  ++   +++pi++v nK+D+ +         
  EFC38481.1 192 VEVSFDHESLKFSLFDVGGQRSERKKWVNCFEGVSAVVYVssladYDLKmyEDDSLNRMDDSLTVFEGLCNgffKETPIIIVLNKTDIFKkklevhgie 290
                 5788999*************99999999999999999887444446654336789999999999999999999999************9999******* PP

                 ............G-SS-HHHHHHHH....HHHTSEEEEEBTTTTCTHHHHHHHHHHHHH CS
         Ras 119 ............kravsteegeela....kelglkfletSAktnenveeafeellreil 161
                             ++ v++ + + l+    +e+ +   e+ A +  +v+++fe++ +++ 
  EFC38481.1 291 qcfkdyngsqdyDESVQFIRNKFLSlnkfDEQRIWIHECCATSTDDVRKVFEQIKHQVA 349
                 ******9999997777766666554545477789999****************998875 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.1    0.0015         3       3      29 ..      40      66 ..      38      76 .. 0.89
   2 !    7.2   0.0    0.0025       5.1      32     114 .]     187     276 ..     180     276 .. 0.65

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0015
                EEEESTTSSHHHHHHHHHTSTEEESSS CS
    MMR_HSR1  3 aivGrpNvGKStLinaltgekaivsdk 29
                +++G   +GKSt++++  +e+ +v+++
  EFC38481.1 40 LLLGSGESGKSTFFKQVQNERRRVKNT 66
                6899999*************9999886 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0025
                 SSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETTTTCSHHHHHHHHHHHHH............TTSEEEEEEES CS
    MMR_HSR1  32 tTrdinegrvklkgkeielvDtpGliegaseekglgkaflaleeadlillvvdaseeklkpldeeleellee............akkplilvlnk 114
                 +T+ i+e  ++++  ++ l D+ G     se+k+  + f+ +  +  +  + d   + +  +d +l+++ ++            ++ p+i+vlnk
  EFC38481.1 187 KTIGIVEVSFDHESLKFSLFDVGG-Q--RSERKKWVNCFEGVSAVVYVSSLADYDLKMY--EDDSLNRMDDSltvfeglcngffKETPIIIVLNK 276
                 6888888888888899********.3..3455555666666544444444444443323..3344444433355566778899999999999998 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.3    0.0042       8.3       1      31 [.      38      63 ..      38      89 .. 0.69
   2 !   11.2   0.2   8.5e-05      0.17      45     135 ..     198     291 ..     172     333 .. 0.72

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0042
   Gtr1_RagA  1 kvLLmGksgsGKtsmrsiiFdnylardtlrl 31
                k+LL+G ++sGK++  + +      ++ +r+
  EFC38481.1 38 KLLLLGSGESGKSTFFKQV-----QNERRRV 63
                89**********9865443.....3444444 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 8.5e-05
   Gtr1_RagA  45 lgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDve.......sreleedletlkeileal.rqyspeakvfvlihKmDliqedereeifee 135
                 ++ l+++l+D+gGq++  ++       + f+ v++++yV           +++  + +++  +++e l   + +e  + + ++K+D  +++ + + +e+
  EFC38481.1 198 HESLKFSLFDVGGQRSERKKW-----VNCFEGVSAVVYVSSLAdydlkmyEDDSLNRMDDSLTVFEGLcNGFFKETPIIIVLNKTDIFKKKLEVHGIEQ 291
                 5789**********9988775.....689**********766633344442222333333333344331457788999999999999998877666655 PP

>> DNA_pol_A_exo1  3'-5' exonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.21   4.2e+02     101     138 ..      49      93 ..      32     106 .. 0.64
   2 !   12.5   0.1   4.4e-05     0.087      68      94 ..     132     158 ..     121     171 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.21
                     SSEEEHHHHHHHTTHSTT......SSHHHHHHHHHS.B---GHCC CS
  DNA_pol_A_exo1 101 enlfdtmlaayvldyers......hsLdsLaekylg.dleldkee 138
                     ++ f  +++++    + +       s++++++k+ + +le++ ee
      EFC38481.1  49 KSTFFKQVQNERRRVKNTvhfnvvSSMAVMCQKLKElNLEFSSEE 93 
                     55555555555555555566777799*******999555554444 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 4.4e-05
                     HHHHHHT-TTSEEEESSHHHHHHHHHH CS
  DNA_pol_A_exo1  68 alkrlledenitkvghnakfDlevlar 94 
                      + +l++d++i+kv++n ++D++v++ 
      EFC38481.1 132 DIYQLWKDSTIQKVFQNNRNDVHVFDG 158
                     56689*******************986 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   2.7   0.00077       1.5     133     191 ..     248     304 ..      41     350 .. 0.50

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00077
  ATP_bind_1 133 qrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek.....lekeleffedvealsllle 191
                 +r++d+ + ++g    l   +  e+P ++vlnk+D++k+k          + f+d +  +   e
  EFC38481.1 248 NRMDDSLTVFEG----LCNGFFKETPIIIVLNKTDIFKKKlevhgI---EQCFKDYNGSQDYDE 304
                 344445555555....333344699*************88642222...233333333333222 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.0   0.00076       1.5       2      35 ..      38      71 ..      37      88 .. 0.79
   2 ?    1.3   0.0      0.11   2.1e+02     105     121 ..     267     283 ..     188     291 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00076
                EEEEEESTTSSHHHHHHHHHTTSEEEEESTTSSS CS
      FeoB_N  2 tvalvGnpnvGkttlfnaltgakqkvgNwpGvtv 35
                ++ l+G   +Gk+t+f ++ + + +v N     v
  EFC38481.1 38 KLLLLGSGESGKSTFFKQVQNERRRVKNTVHFNV 71
                56899*********************99665555 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.11
                 TSSEEEEEETHHHHHHT CS
      FeoB_N 105 gvpvvlalnmideaekk 121
                 ++p++++ln++d  +kk
  EFC38481.1 267 ETPIIIVLNKTDIFKKK 283
                 5799********99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       785  (0.0437838); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 2245.24
//
Query:       EFC38482.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.9e-78  260.6   0.2    9.2e-78  260.2   0.2    1.2  1  eIF-6     eIF-6 family


Domain annotation for each model (and alignments):
>> eIF-6  eIF-6 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  260.2   0.2   5.1e-82   9.2e-78       1     196 [.       4     203 ..       4     204 .. 0.98

  Alignments for each domain:
  == domain 1  score: 260.2 bits;  conditional E-value: 5.1e-82
                 .E-BTTB--HHHH-EE-SSEEEE-TTS-HHHHHHHHHHHT..-EEEE--BTTBS-HHHH-EE-SSEEEEETT--HHHHHHHHHHHH---..EEE--SS- CS
       eIF-6   1 rlsiegsseiGvfarltnkyalvpegveeefvkaieeeLk..vevvettiagsrlvGslvvgNsngllvpstvtdeeleklkeslklev..erleeklt 95 
                 r+++++ss+iGvf++ltn yalv++g++++f++ +e+eL   ++v  +tiag+r++G+l++gN++gl+vpst+td+el +l+++l+++v  +r+e++l+
  EFC38482.1   4 RTQFQSSSDIGVFSVLTNGYALVAQGTSANFYSSFETELIdhIPVNYATIAGCRIIGTLCAGNKKGLVVPSTTTDQELMHLRNCLPESVklTRVEDRLS 102
                 789************************************888********************************************888779******* PP

                 -HHHHEEE-SSEEEE-GGGGG.GHHHHHHHHTSEEEE--BTTBS-TTTSEEE-SSEEEE-TT--HHHHHHHHHHHT-SEEE--BTTTBS-GGGTEEE-S CS
       eIF-6  96 AlGNvilaNDkvAlvhpdlsketveiiadvLgvevvrgtiagiktvGsaavvtnkgllvhpkateeeleeleellkveveagTvNrGsklvgsglvaNd 194
                 AlGN+i++ND+vAl+h+d++k+t+eii+d+Lgve++r+ti+g+++vGs++v++n+g++vhpk++ +e+++l++ll+v++ agT+NrGs+ +g+glv+Nd
  EFC38482.1 103 ALGNCIACNDYVALIHKDMDKNTEEIIQDTLGVETFRTTINGNPLVGSYCVFSNQGGIVHPKTSVKEQDKLSQLLQVPIVAGTINRGSESIGAGLVVND 201
                 *************************************************************************************************** PP

                 S- CS
       eIF-6 195 kg 196
                 ++
  EFC38482.1 202 WA 203
                 97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       407  (0.0227007); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1660.12
//
Query:       EFC38483.1  [L=533]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        8.7    6.7  13.2        4.5    7.7   0.5    3.4  3  DUF3232   Protein of unknown function (DUF3232)


Domain annotation for each model (and alignments):
>> DUF3232  Protein of unknown function (DUF3232)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   1.3     0.016   2.8e+02      48     123 ..       4      80 ..       1      85 [. 0.61
   2 ?    7.7   0.5   0.00025       4.5       2      40 ..      98     136 ..      97     140 .. 0.91
   3 ?    4.2   0.3    0.0029        53      36      72 ..     420     457 ..     398     465 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.016
                 HHHHHHHCCTS-HHHHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHTT-T-HHHHHHHHHHHHHHHH CS
     DUF3232  48 earlasarfrleaeelkelveelDrsRrlahnslisslk.iinrllvkeeveelseagledRieiaefakellseiy 123
                 e+ l++ ++ l  e l    +   + +r++h  li+s   i+ + l +++v++ +  ++ dR+   e   e+  + y
  EFC38483.1   4 ETTLNIEQLELKNEKLFGKSKLKIENKRIEHVKLIKSNDmILSKNLLQKHVNSEKLKEISDRLITCELELEVKLQYY 80 
                 55555666666666655444433455778888888776525567777777776666777788777776666655555 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00025
                 XXX-TTSHHHHHHHHHHHHTTSHHHHHHHHHHHHHHHHH CS
     DUF3232   2 lqkkeeevterlkkvaeiiksDevalelledlidaatrY 40 
                 +qk++e ++e+ ++v +ii+ D+ + ++l+  ida  + 
  EFC38483.1  98 YQKESESLIEYEEQVQKIIQIDDTICKMLNHDIDAFREL 136
                 6899******************************98765 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.0029
                 HHHHHHHHHHHHHH.HHHHHCCTS-HHHHHHHHHHHHH CS
     DUF3232  36 aatrYvkkvvemea.rlasarfrleaeelkelveelDr 72 
                 ++++Y+    ++++ r  ++++++e e++++ + +l +
  EFC38483.1 420 NYSNYFDLPSNVDElRTMIIKLQFEKEDMRNEISKLKQ 457
                 67889988888765156689***********9999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (533 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2757  (0.153773); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.50
# Mc/sec: 3232.63
//
Query:       EFC38484.1  [L=170]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.17   12.5   0.9        1.6    9.4   0.1    2.4  2  QIL1      MICOS complex subunit MIC13, QIL1


Domain annotation for each model (and alignments):
>> QIL1  MICOS complex subunit MIC13, QIL1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.2     0.025   4.5e+02      32      73 ..      86     121 ..      64     124 .. 0.67
   2 ?    9.4   0.1   8.8e-05       1.6      45      70 ..     133     159 ..     111     164 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.025
        QIL1  32 kkklclevpklpsveevkfslveyWNkgVkkvfsflselPty 73 
                 k+++c e    ps    ++ ++++ N g++ + sf ++l t+
  EFC38484.1  86 KQQICAE--CSPS----NQQFISTSNYGINVCKSFCEKLNTE 121
                 3444433..2222....2367888888888888888877665 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 8.8e-05
        QIL1  45 veevkf.slveyWNkgVkkvfsflsel 70 
                 +++++  +  +++N+gV + +s+l+++
  EFC38484.1 133 QPDCSTyPTTNCYNSGVINQVSALAMF 159
                 4555555999**************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       941  (0.0524848); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1104.51
//
Query:       EFC38485.1  [L=568]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-72  245.2   1.8    5.2e-63  213.4   0.3    2.1  2  p450      Cytochrome P450
  ------ inclusion threshold ------
      0.044   13.6   2.9       0.11   12.3   2.2    2.0  2  AAA_11    AAA domain
       0.25   11.7   4.9        9.6    6.6   0.4    2.7  2  FtsH_ext  FtsH Extracellular


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2   0.1   1.6e-11   9.4e-08       6     142 ..      58     189 ..      55     200 .. 0.82
   2 !  213.4   0.3   8.7e-67   5.2e-63     190     461 ..     273     562 ..     238     564 .. 0.88

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 1.6e-11
                 EHHCCHCHHHHTTTCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHH CS
        p450   6 plplvgnllqlgrkeelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltp 104
                  +pl+ n  ++ + +++ e  +++  + g+ifrl + +++++ l + +++k+v i+k++ f    +++ ++++ + + ++ +   n+e wkk++r++ p
  EFC38485.1  58 HIPLIANYCNFTTADKVRELSFQFGGE-GKIFRLSMCNQNMIWLLDRDLIKQVNITKANTFD---KPNYVYQAFRIYGENLLSAPNHEIWKKHHRIVSP 152
                 578889999999888888888888888.9****************************63333...5677777666677777777777************ PP

                 HHTSHSTT.THHHHHHHHHHHHHHHHHCCCCHCSEEETH CS
        p450 105 tltsfgkl.sleelveeeaedlveklrkkagesseldit 142
                 ++  + +l  + ++ ++ +++l+e++ k  + + +++i 
  EFC38485.1 153 AFSAK-NLeLVCQISNQASDMLIERWIKLLNNN-TISIN 189
                 *****.776688999999999***999988888.56665 PP

  == domain 2  score: 213.4 bits;  conditional E-value: 8.7e-67
                 HCCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC......................SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHH CS
        p450 190 qllllfpllkylptkllrklkeavkklkdlldklieerretldsa......................kksrrdfldalllakkekkgesklsdeelaat 266
                 ++ ll++ l+  +t+ ++ l+ + + +++++d+ i+e +++ +++                       ++r+d+l++l+ a    ++ s l++ el+ +
  EFC38485.1 273 EYPLLYK-LLLNLTSVGKALDYIGQSIDNMIDERINEIKQSSNNNsnninsnndsnsvstfnsneidWDERKDLLSLLVRAN--LQD-SVLTRGELKSN 367
                 2455555.446899*****************************99*******************9995589**********6..555.59********* PP

                 HHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCCTTTT-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETT.EEE-TT-EEE CS
        p450 267 vlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlgdkreptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirg.ylipkGtevi 364
                 +l++ +aG+dT+s+ l+w +yeL k+ ++q+++++Eid+ lg++ e+ty+d+ k +y + v+ E LR+hp+v   + + v k  +i g y ipkGt++ 
  EFC38485.1 368 ALVFSLAGYDTSSTSLQWLMYELSKHVNIQKECQHEIDTLLGNN-EFTYNDFDKFEYITSVVMECLRIHPPVF-EVDKIVAKKNTIIGeYEIPKGTQIN 464
                 *****************************************997.6***************************.****99997777777********** PP

                 EEHHHHHT-TTTSSSTTS--GGGGB-TTS.CTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSCSSEEESSSSEE CS
        p450 365 vnlyalhrdpevfpnPeeFdpeRFldekg.nskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileksglllppkpikl 461
                 +nl  ++rd+++++nP+eF+p RF  +++ ++ +++++++PF+ G R CiG ++A+me+  ++++lLq++++ l +++ + pi  +++l+ +p ++k+
  EFC38485.1 465 INLIDVNRDEKLWENPQEFNPNRFKTQQEkEFVQNNHQWIPFSSGNRRCIGYKFAQMEITSVIIRLLQKCNFILLNDEIKDPIGIETSLTSKPTNLKI 562
                 *************************999988889****************************************987777777777677777777665 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   2.2   1.8e-05      0.11      48     122 ..     151     295 ..     121     369 .. 0.59
   2 ?   -2.5   0.0      0.59   3.5e+03     234     246 ..     502     514 ..     440     514 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.8e-05
      AAA_11  48 eeeksakpriLvCapSNaAvDellerllrglldsegekykpkivRvgnee...eriseavksvsleekvekrlekee...................... 121
                 + + sak+  LvC  SN A D l+er ++ ll+++  +++ +i + gn++   +   e+ +++++   +     +++                      
  EFC38485.1 151 SPAFSAKNLELVCQISNQASDMLIERWIK-LLNNNTISINSNISKNGNNQqlvQINIEDFSELTMTVLLAGGFGMKTvptfldsdskknqlytnemnkg 248
                 4566788889*******************.9**************999995542223444444555555555555444444444444444444444444 PP

      AAA_11 122 ..............................................k 122
                                                                
  EFC38485.1 249 nefvsnmeivwrralvlrrfvqqdeypllyklllnltsvgkaldyiG 295
                 44444455555555555555555555554444444333333333332 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.59
      AAA_11 234 tliPlrlgakkvv 246
                  +iP+++g ++++
  EFC38485.1 502 QWIPFSSGNRRCI 514
                 4777777777776 PP

>> FtsH_ext  FtsH Extracellular
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.4    0.0016       9.6       2      32 ..      14      79 ..      13     130 .. 0.63
   2 ?    6.3   0.4     0.002        12      27      98 ..     242     350 ..     212     361 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0016
    FtsH_ext  2 llwlllallllllllslfg...................................gsgtgstkeisy 32
                + +ll+a+l++l+++ ++                                    ++++ + +e+s+
  EFC38485.1 14 INTLLIAILVILIFYIFNIlyrvyknvklvkhipgywqiiytpfhiplianycnFTTADKVRELSF 79
                567899999999999998777776666666666665555555555555555555444446666666 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.002
    FtsH_ext  27 tkeisy.seFledleqgnvekvvvqestis......................................alirrptgdgvsttkkgnstttystptlgsv 86 
                 t+e++  +eF+ + e++ ++  v+++  ++                                      ++ ++++ +  ++++++ns +t+++      
  EFC38485.1 242 TNEMNKgNEFVSNMEIVWRRALVLRRFVQQdeypllyklllnltsvgkaldyigqsidnmiderineiKQSSNNNSNNINSNNDSNSVSTFNSNE---I 337
                 677777799999999999999999977777888999999999999999999999999999999**9*9999*******************99999...7 PP

    FtsH_ext  87 esleek.Leealk 98 
                 +++e+k L ++l+
  EFC38485.1 338 DWDERKdLLSLLV 350
                 7777776555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (568 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1182  (0.0659267); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 3452.85
//
Query:       EFC38486.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.063   13.2   0.0       0.16   12.0   0.0    1.6  1  RL        RL domain


Domain annotation for each model (and alignments):
>> RL  RL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   8.7e-06      0.16      12      42 ..     105     134 ..      95     141 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 8.7e-06
          RL  12 QAersvLiscpskisekkllkylsqhGkink 42 
                 Q  rs++i++ sk++  +l++yl +hG+++ 
  EFC38486.1 105 QPCRSIIIELISKVNP-QLYNYLIKHGHVKD 134
                 778***********96.6**********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1063  (0.0592894); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1383.02
//
Query:       EFC38487.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-08   35.5  23.2    2.1e-08   35.0  23.2    1.4  1  PLAC8     PLAC8 family
  ------ inclusion threshold ------
       0.29   11.6   5.7       0.49   10.8   5.7    1.4  1  GP67      Gene product 67


Domain annotation for each model (and alignments):
>> PLAC8  PLAC8 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.0  23.2   2.4e-12   2.1e-08       8      99 .]     121     211 ..      45     211 .. 0.74

  Alignments for each domain:
  == domain 1  score: 35.0 bits;  conditional E-value: 2.4e-12
       PLAC8   8 c....fsdlevcllalfc.pcvllgqnaerldsgnlscllllvlllallvllglgllatlllRskiRekynie.gssceDclaslcCacCalaQeare 99 
                 c      d++  +++++c pc + + +++++++++ s ++++++      ++++  ++++++R+  R+ y+i+ g+ c+Dc++ ++C+cC+ aQ  re
  EFC38487.1 121 CkiypARDFNETCYTCCClPC-ANADALKYVKNNQSSWWCTCCI------SCCFPTIMSTIVRNITRKLYGIQqGNACTDCCVGTFCSCCSSAQVLRE 211
                 255655678878889999999.5566666666665554432222......2334556899************9999******************9887 PP

>> GP67  Gene product 67
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   5.7   5.4e-05      0.49      40      75 ..      65     101 ..      36     107 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 5.4e-05
        GP67  40 arnfliege.epededededdedsddkddkkdedsde 75 
                 ++ f+i+ + e +ded++e + +  d dd +d dsd+
  EFC38487.1  65 TKYFVIQNNvEYDDEDDEESQHQNVDYDDSQDSDSDN 101
                 566777654378888888889999999*******997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1380  (0.0769703); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.41
# Mc/sec: 1624.87
//
Query:       EFC38488.1  [L=895]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.1e-34  115.5   9.8     0.0099   16.7   0.0   12.5 12  WD40             WD domain, G-beta repeat
     0.0014   18.8   1.0     0.0091   16.1   0.3    2.7  2  VirDNA-topo-I_N  Viral DNA topoisomerase I, N-terminal
     0.0032   17.5   2.9        5.8    7.0   0.2    4.9  5  BBS2_Mid         Ciliary BBSome complex subunit 2, middle reg
     0.0047   17.2   4.0         17    5.8   0.0    6.2  6  ANAPC4_WD40      Anaphase-promoting complex subunit 4 WD40 do
  ------ inclusion threshold ------
      0.059   13.0   0.1       0.14   11.8   0.1    1.7  1  SMRP1            Spermatid-specific manchette-related protein


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0013       4.5       4      38 .]      91     134 ..      88     134 .. 0.85
   2 !    6.0   0.0    0.0068        24       8      37 ..     153     179 ..     145     180 .. 0.81
   3 !    6.0   0.0    0.0068        24       2      37 ..     187     224 ..     186     224 .. 0.81
   4 !   16.7   0.0   2.8e-06    0.0099       3      38 .]     231     271 ..     229     271 .. 0.74
   5 !   15.3   0.1   7.6e-06     0.027       7      38 .]     319     353 ..     313     353 .. 0.85
   6 !   11.2   0.0   0.00015      0.55       1      35 [.     415     452 ..     415     455 .. 0.80
   7 ?    4.0   0.0     0.029   1.1e+02      13      35 ..     494     515 ..     486     516 .. 0.81
   8 !    8.0   0.0    0.0016       5.8       4      38 .]     629     669 ..     626     669 .. 0.74
   9 !   12.7   0.0   5.1e-05      0.18       3      37 ..     676     711 ..     674     712 .. 0.84
  10 !   10.7   0.0   0.00022      0.78       9      37 ..     730     759 ..     720     760 .. 0.85
  11 ?    3.2   0.0     0.052   1.9e+02      24      38 .]     819     833 ..     789     833 .. 0.74
  12 ?    4.7   0.0     0.017        63      13      37 ..     860     891 ..     848     892 .. 0.68

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0013
                 EEEEESS.SSEEEEE.........EETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtsla.........fspdgawlasGsdDgtvriWd 38 
                 l tl+GH   v++++         f+ +  +++s +  + v iW+
  EFC38488.1  91 LCTLKGHtERVNAVSfmiysnsqeFDNNTIYITSVG-GKEVIIWK 134
                 7799***66699999999999999999999998878.99999995 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0068
                 ESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 ++H + vtsl    ++++++ ++ Dg+v ++
  EFC38488.1 153 KTHlTKVTSL----EQRYIVVADSDGHVFVY 179
                 589888****....99**999955****987 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0068
                 EEEEEEESSSSEEEEE..EETTSSEEEEEETTSEEEEE CS
        WD40   2 qclrtltGHssvtsla..fspdgawlasGsdDgtvriW 37 
                 ++++t++ H+ + +++     d+ ++a+G+ D +++++
  EFC38488.1 187 ELIQTFKHHKAIEAVSmiKLFDHYMVACGGVDFNIHLY 224
                 57899**9999999977655566669999****99986 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 2.8e-06
                 EEEEEESS.SSEEEEE....EETTSSEEEEEETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtsla....fspdgawlasGsdDgtvriWd 38 
                  + +l+GH +++++l+      ++  +las+s D+ +r+W+
  EFC38488.1 231 SVLVLKGHeDWIRALSfkfiPIDNCVYLASASQDNRIRLWK 271
                 56789***888988865544333333599***********6 PP

  == domain 5  score: 15.3 bits;  conditional E-value: 7.6e-06
                 EESS.SSEEEEEEETTSSE..EEEEETTSEEEEEE CS
        WD40   7 ltGH.ssvtslafspdgaw..lasGsdDgtvriWd 38 
                 ltGH ++v+sl ++p  ++  l+s s+D+t  iW+
  EFC38488.1 319 LTGHeDWVHSLNWHPIPNMlqLVSTSMDRTMTIWS 353
                 79**888****8888888877688899*******5 PP

  == domain 6  score: 11.2 bits;  conditional E-value: 0.00015
                 TEEEEEEESS.SSEEEEE..EETTSSEEEEEETTSEEE CS
        WD40   1 gqclrtltGH.ssvtsla..fspdgawlasGsdDgtvr 35 
                 ++++ +++GH +sv +l+   s+dg ++++ s D+t r
  EFC38488.1 415 WKPMVSISGHfNSVMDLDvePSKDGLYFMTTSSDQTTR 452
                 5788899***999*888877999999987655599977 PP

  == domain 7  score: 4.0 bits;  conditional E-value: 0.029
                 EEEEEEETTSSEEEEEETTSEEE CS
        WD40  13 vtslafspdgawlasGsdDgtvr 35 
                  ++laf ++ ++ asG+d + +r
  EFC38488.1 494 MNCLAFTDYYSF-ASGGDEKVIR 515
                 69**********.79**777776 PP

  == domain 8  score: 8.0 bits;  conditional E-value: 0.0016
                 EEEEESS.SSEEEEEEETTSSEEEEE.ET....TSEEEEEE CS
        WD40   4 lrtltGH.ssvtslafspdgawlasG.sd....DgtvriWd 38 
                 +++l GH + + +++ + +++ la++ s        +r+Wd
  EFC38488.1 629 QQKLYGHaNEIICVSSNNSKTILATAcSAkqanAAQIRLWD 669
                 67889**99988**999999999965253345577777776 PP

  == domain 9  score: 12.7 bits;  conditional E-value: 5.1e-05
                 EEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 ++ ++ GH   v+ +afs +  w++s s+D+ + ++
  EFC38488.1 676 PIDVIPGHnLTVSRIAFSNNDEWMCSVSRDRCLILY 711
                 667889**444*************988****98776 PP

  == domain 10  score: 10.7 bits;  conditional E-value: 0.00022
                 SSSS.EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   9 GHss.vtslafspdgawlasGsdDgtvriW 37 
                  H   +++ +f  d +++a+Gs+D  ++i+
  EFC38488.1 730 CHERiIWDASFTYDDKYVATGSRDEVIKIF 759
                 574447**********************97 PP

  == domain 11  score: 3.2 bits;  conditional E-value: 0.052
                 EEEEEETTSEEEEEE CS
        WD40  24 wlasGsdDgtvriWd 38 
                 +la G++Dg++ i+d
  EFC38488.1 819 LLAIGMEDGSIQIYD 833
                 2778*********98 PP

  == domain 12  score: 4.7 bits;  conditional E-value: 0.017
                 EEEEE.....EETTSSE..EEEEETTSEEEEE CS
        WD40  13 vtsla.....fspdgaw..lasGsdDgtvriW 37 
                 v+ ++      +p+g    l+s+s D +vr++
  EFC38488.1 860 VRRVKwrvdaSNPNGIRleLLSCSLDYSVRLY 891
                 5666444335566666677689********98 PP

>> VirDNA-topo-I_N  Viral DNA topoisomerase I, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.3   2.5e-06    0.0091      18      47 ..     137     166 ..     133     178 .. 0.91
   2 ?   -1.1   0.0      0.61   2.2e+03      19      33 ..     180     194 ..     169     204 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 2.5e-06
                      --TT-THHHHHHH----TT-EEEEEE---H CS
  VirDNA-topo-I_N  18 VsddNptYeilkkvkiPkhLtdvvvyeqtl 47 
                      ++++  tYei++ +k  +hLt v  +eq +
       EFC38488.1 137 INQSEITYEIVQTIKSKTHLTKVTSLEQRY 166
                      778999**********************98 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.61
                      -TT-THHHHHHH--- CS
  VirDNA-topo-I_N  19 sddNptYeilkkvki 33 
                      ++ N+ Ye ++  k 
       EFC38488.1 180 EKKNQVYELIQTFKH 194
                      568999999998885 PP

>> BBS2_Mid  Ciliary BBSome complex subunit 2, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.2    0.0016       5.8      31      73 ..     145     187 ..     125     211 .. 0.84
   2 ?    1.4   0.0     0.088   3.1e+02      10      40 ..     253     283 ..     244     298 .. 0.78
   3 ?    0.6   0.0      0.16   5.6e+02      12      40 ..     744     774 ..     738     789 .. 0.70
   4 ?    3.4   0.0     0.022        78      45      68 ..     812     835 ..     800     858 .. 0.79
   5 ?   -3.3   0.0       2.5     9e+03      14      27 ..     878     891 ..     874     892 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0016
    BBS2_Mid  31 elvaeitetekvvslarlekerfayaleNGtvgvyekkerlWr 73 
                 e+v++i+ + + + +++le++ +++a + G v vyekk+++++
  EFC38488.1 145 EIVQTIKSKTHLTKVTSLEQRYIVVADSDGHVFVYEKKNQVYE 187
                 7889999999999999999999999999999999999998765 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.088
    BBS2_Mid  10 dgeneLvvgsddfeirvfkeeelvaeitete 40 
                 d+  +L  +s+d++ir++k  +++ +  +++
  EFC38488.1 253 DNCVYLASASQDNRIRLWKITKVTEQDANHS 283
                 445788999*********9998887766555 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.16
    BBS2_Mid  12 eneLvvgsddfeirvfk..eeelvaeitete 40 
                 ++++  gs d  i++fk   ee+ + i+e++
  EFC38488.1 744 DKYVATGSRDEVIKIFKlpSEEAANAIRESN 774
                 678899**********844455555555544 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.022
    BBS2_Mid  45 larlekerfayaleNGtvgvyekk 68 
                  ++l++  +a+++e G++ +y++ 
  EFC38488.1 812 SKNLSPYLLAIGMEDGSIQIYDNV 835
                 56778888999**********974 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 2.5
    BBS2_Mid  14 eLvvgsddfeirvf 27 
                 eL+ +s d+++r++
  EFC38488.1 878 ELLSCSLDYSVRLY 891
                 8999********98 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1     0.056     2e+02      35      81 ..     153     197 ..     126     209 .. 0.68
   2 ?    0.7   0.0      0.19   6.8e+02      38      69 ..     239     274 ..     208     289 .. 0.66
   3 ?   -1.9   0.0       1.2   4.2e+03      37      54 ..     322     339 ..     310     353 .. 0.75
   4 ?    0.4   0.0      0.22   8.1e+02      35      68 ..     681     714 ..     642     727 .. 0.78
   5 ?    1.2   0.0      0.13   4.6e+02      44      82 ..     738     776 ..     725     798 .. 0.79
   6 !    5.8   0.0    0.0048        17      52      76 ..     819     844 ..     814     869 .. 0.65

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.056
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysdgevrlldaesg..kvvhslsvkse 81 
                  +++  +v+sL    + + ++va sdg+v +++ +++  +++++++ ++ 
   EFC38488.1 153 KTHLTKVTSL----EQRYIVVADSDGHVFVYEKKNQvyELIQTFKHHKA 197
                  4455555555....46899**********99988763355666555544 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.19
  ANAPC4_WD40  38 dsevrsLaWk..p..dgklLavaysdgevrlldaes 69 
                  +  +r+L++k  p  +   La a +d+++rl ++ +
   EFC38488.1 239 EDWIRALSFKfiPidNCVYLASASQDNRIRLWKITK 274
                  455555555532221344699999999999987765 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.2
  ANAPC4_WD40  37 edsevrsLaWkpdgklLa 54 
                  ++  v+sL+W+p  ++L 
   EFC38488.1 322 HEDWVHSLNWHPIPNMLQ 339
                  455688899998777775 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.22
  ANAPC4_WD40  35 dkedsevrsLaWkpdgklLavaysdgevrlldae 68 
                  ++++ +v+ +a++++++ ++ +  d  + l++ +
   EFC38488.1 681 PGHNLTVSRIAFSNNDEWMCSVSRDRCLILYQKK 714
                  5678899999999999999999888776666544 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.13
  ANAPC4_WD40  44 LaWkpdgklLavaysdgevrlldaesgkvvhslsvksek 82 
                   ++  d+k  a +  d  +++++  s++  ++++ ++ek
   EFC38488.1 738 ASFTYDDKYVATGSRDEVIKIFKLPSEEAANAIRESNEK 776
                  56888999**************99999999988877765 PP

  == domain 6  score: 5.8 bits;  conditional E-value: 0.0048
  ANAPC4_WD40  52 lLavaysdgevrlldaes.gkvvhsl 76 
                  lLa++++dg+++++d  s  + v ++
   EFC38488.1 819 LLAIGMEDGSIQIYDNVStDENVIKM 844
                  7999*********9854404444444 PP

>> SMRP1  Spermatid-specific manchette-related protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   3.8e-05      0.14      16      93 ..      53     141 ..      37     161 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.8e-05
       SMRP1  16 tdsyraptsikevykdpplwaweankfv...tpgltk...tmerhvdp.ealekmvkcavedys....ykssvsghpylpekywlseee 93 
                 t+  r  ++ike+y+   l+a+ an+fv   +p  ++   t++ h+++ +a+  m+  +++++     y +sv g+  +  k  + + e
  EFC38488.1  53 TNCIRVDAAIKEKYRHLDLFAYSANQFVaiySPYYNRilcTLKGHTERvNAVSFMIYSNSQEFDnntiYITSVGGKEVIIWKLNINQSE 141
                 677899*********************94444666552226799998647999999999999852233667888888887777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (895 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       718  (0.0400469); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.47
# Mc/sec: 5723.85
//
Query:       EFC38489.1  [L=189]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-11   44.8   0.0    2.4e-11   44.0   0.0    1.4  1  Ribosomal_L11    Ribosomal protein L11, RNA binding domain
     0.0039   17.0   0.0     0.0073   16.1   0.0    1.4  1  Ribosomal_L11_N  Ribosomal protein L11, N-terminal domain


Domain annotation for each model (and alignments):
>> Ribosomal_L11  Ribosomal protein L11, RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.0   2.7e-15   2.4e-11      10      70 .]     104     163 ..      99     163 .. 0.81

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 2.7e-15
                    HHHHTXSSXXSSTTTSXX..EEEEHHHHHHHHHHHGGGHTXS.SHHHHHHHHHHHHCTTTEEE CS
  Ribosomal_L11  10 kkaagiekgsgkpgketv..GtvslkqvyeIAkiKksdlnaalsleaavksilgtArsmGikV 70 
                    ++ +g+ + +++    +v  G+++++q+++IA++Kks+++a+ +l a vk++lgt+ s+G+kV
     EFC38489.1 104 ISNLGEAPSDKQ--YHVVhdGNLTFDQLIHIAQTKKSSKTAR-TLTAKVKEVLGTCVSIGCKV 163
                    556666553333..333467****************998888.*******************9 PP

>> Ribosomal_L11_N  Ribosomal protein L11, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   8.2e-07    0.0073      12      59 ..      37      85 ..      32      90 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 8.2e-07
  Ribosomal_L11_N 12 vpaGkAtpaPplGpaLGplGlnikkfckefnkaTkd..kkglripVkitv 59
                     v +++ +p  +l+p +GplG+++k + + +++  +   +    i+V+  v
       EFC38489.1 37 VRSQQPNP-GKLAPVFGPLGISPKVISQRITELVQAlnWSAKHITVRFIV 85
                     66677788.59*********************998556999999999988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       522  (0.0291148); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1174.01
//
Query:       EFC38490.1  [L=363]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-33  114.5   0.2    1.1e-32  113.9   0.2    1.3  1  DUF2817   Protein of unknown function (DUF2817)


Domain annotation for each model (and alignments):
>> DUF2817  Protein of unknown function (DUF2817)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.9   0.2   5.9e-37   1.1e-32      45     335 ..       2     310 ..       1     314 [. 0.80

  Alignments for each domain:
  == domain 1  score: 113.9 bits;  conditional E-value: 5.9e-37
     DUF2817  45 lgpadakklLvltsGthGveGfaGSavqvalLrea..lakllaegvavLlvhalNPyGfahlrrvnedNVDLnRNfl.....dfskplpenkaYeelhe 136
                 l+++ ++++ +  sG+hG eGf+GS +q+a+++++  ++ +l++++  + +h lNPyG ++  + ne+NVD+  N       +   ++++n   e++  
  EFC38490.1   2 LKNKAESNVFLTFSGVHGQEGFVGSPIQIAMIKNDtkYQFNLPDNTYPVHIHMLNPYGASYATKENENNVDMLKNLNehyidAPGWEISKNVLLEQFID 100
                 56788999**************************98889999*****************************9999884433333445677888888888 PP

     DUF2817 137 lllpkewppsav.aealaallkyiekhGlkalqqalsrGQyehpdGlfyGGtepewsnrtlreilkehlaaa.......ervaviDlHTGlGprgkgei 227
                  ++ ++++ ++v a+a + +  +++k Gl a+ q+   GQ +   G+ y Gt++ew  ++++ il++ l+++       ++v +iDlH+ +G++g+  +
  EFC38490.1 101 GMNISHLHLDTVqAQAVNYFYTLLAKVGLPAFTQSSVIGQIHRQIGIAYAGTTEEWTAKQVKIILNQLLKGYsseytksRKVLYIDLHSAVGEYGNVYA 199
                 8888888877775667778889999*************************************9999988777677778799****************** PP

     DUF2817 228 ivsseedkealerarkwwgkevtskaegssssaeltglliealaeelp.eaeltai..tleFgtlpllkvlralraenwlhqhae..ads.eqaaaike 320
                 +++ e  + a +   k   +e ++++     s ++ g++i+  a + + ea+lt++  + e gt p  +  ++      ++++++  ++s +    +++
  EFC38490.1 200 MFDPEWIPFAKQYLLK---NEYIHDNLFPFPSGKYFGHFIKDHALMSGsEANLTIVptAWEIGTFPQDAYQNYFLMQLNCRFYQNlpDRSaQFCPFVNS 295
                 9998555544444433...4667776668888888999988755555404556555215677**999988888777777776666523341445566** PP

     DUF2817 321 elrdaFypdeeewke 335
                 ++ + Fyp++++wk+
  EFC38490.1 296 KVGEYFYPQDDSWKT 310
                 *************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (363 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       582  (0.0324614); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 2436.05
//
Query:       EFC38491.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   13.1   0.1       0.21   12.2   0.1    1.4  1  FOXP-CC   FOXP coiled-coil domain
       0.14   12.0   0.1        0.2   11.5   0.1    1.3  1  DUF2313   Uncharacterised protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> FOXP-CC  FOXP coiled-coil domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   2.3e-05      0.21       5      35 ..      95     125 ..      93     141 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.3e-05
     FOXP-CC   5 gvCkWPgCekvledveeflkhlnseHalddk 35 
                 + Ck P+C++++ ++++++ h++++ + ++ 
  EFC38491.1  95 QFCKDPDCKEAFMELKKMILHIKHDPSSTQS 125
                 68********************988666554 PP

>> DUF2313  Uncharacterised protein conserved in bacteria (DUF2313)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   2.2e-05       0.2      41      80 ..      37      74 ..      21      93 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.2e-05
     DUF2313 41 elfpetatelLkdWEkvlglpdnssetleeRRaavlakln 80
                 + ++    lL dWE++l+lp++ +   ++RR+ + ak n
  EFC38491.1 37 LQKVNPNMILLIDWESILSLPEDLK--WKARREELSAKEN 74
                5555666679***********9887..9999999999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       440  (0.0245412); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1148.41
//
Query:       EFC38492.1  [L=334]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.8e-24   84.5   0.1    1.1e-23   83.7   0.1    1.4  1  Ras              Ras family
    1.3e-10   41.5   0.0    2.7e-10   40.5   0.0    1.5  1  Roc              Ras of Complex, Roc, domain of DAPkinase
    3.8e-10   39.6   0.1    5.5e-10   39.1   0.1    1.3  1  GTP_EFTU         Elongation factor Tu GTP binding domain
    5.3e-09   35.8   0.1    9.2e-09   35.0   0.1    1.3  1  Arf              ADP-ribosylation factor family
    1.7e-05   24.3   1.2    2.6e-05   23.7   0.2    1.8  2  Gtr1_RagA        Gtr1/RagA G protein conserved region
     0.0001   22.3   0.3       0.62   10.0   0.2    2.5  2  RsgA_GTPase      RsgA GTPase
     0.0028   17.7   1.8     0.0077   16.2   1.6    1.9  1  MMR_HSR1_Xtn     C-terminal region of MMR_HSR1 domain
     0.0093   16.0   0.2      0.021   14.9   0.0    1.7  2  MMR_HSR1         50S ribosome-binding GTPase
  ------ inclusion threshold ------
      0.011   15.6   0.3      0.045   13.7   0.1    1.9  2  DUF494           Protein of unknown function (DUF494)
      0.043   14.1   0.1      0.091   13.0   0.1    1.7  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
      0.071   13.0   0.0        0.2   11.6   0.0    1.8  1  F-box            F-box domain
        0.1   13.0   0.2        0.3   11.5   0.2    1.8  1  CM_1             Chorismate mutase type I
       0.12   13.1   0.6       0.92   10.2   0.0    2.5  3  PglD_N           PglD N-terminal domain
        1.7    8.7   4.4          6    6.9   0.2    2.4  2  CbiA             CobQ/CobB/MinD/ParA nucleotide binding domai


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.7   0.1   8.3e-27   1.1e-23       1     159 [.     123     292 ..     123     294 .. 0.86

  Alignments for each domain:
  == domain 1  score: 83.7 bits;  conditional E-value: 8.3e-27
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K+v++G ++vGK+s++++  +++F e y++T   + y+k ++vd+  v +++ D AG e+++++++ y+r+++ ++ v d+ ++++ e+ ++ ve++ +
  EFC38492.1 123 KIVMIGAGGVGKSSITINCFHGHFIEFYDPTT-DEPYRKLLQVDNLPVMIDVIDPAGIEDYSAMTDYYMRSGDTFINVCDVVDEKTVEQSERVVEQVIK 220
                 9*******************************.99*************************************************************988 PP

                 HST...TTSEEEEEEETTTGGG....G-SS-HHHHHHHH......HHHTSEEEEEBTTTTCTHHHHHHHHHHH CS
         Ras 100 vae...envpivLvGnKvDlee....kravsteegeela......kelglkfletSAktnenveeafeellre 159
                  +    + +p++   nKvDl +    +++++ +  + +       + ++++ +  SAkt en + +fee++r+
  EFC38492.1 221 LKCreiNYFPVIFALNKVDLLNdsnrEQVIE-KYTNLINsiiernQLKNTAIFTSSAKTGENTKLLFEECVRR 292
                 7665888899**********98887533333.33322223443323344778899**************9985 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.5   0.0   2.1e-13   2.7e-10       1     119 [.     123     239 ..     123     240 .. 0.79

  Alignments for each domain:
  == domain 1  score: 40.5 bits;  conditional E-value: 2.1e-13
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K+v++G +gvGK+s+  +  +++f e +++t+   + +  + ++++      +  v +++ D aG e++++++++y+r+ + +i v+d   +++ e+ +
  EFC38492.1 123 KIVMIGAGGVGKSSITINCFHGHFIEFYDPTTDEPYRK--LLQVDN------L-PVMIDVIDPAGIEDYSAMTDYYMRSGDTFINVCDvvdEKTVEQSE 212
                 9******************************9988743..334443......2.589***************************998866556666666 PP

                 HHHHHHHHH.CSSS...-EEEEEE-TT CS
         Roc  97 eWlkelkkv.agks...pvilvgnkiD 119
                 + ++++ k  ++++   pvi+  nk+D
  EFC38492.1 213 RVVEQVIKLkCREInyfPVIFALNKVD 239
                 66665544314443345899999**99 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1   0.1   4.3e-13   5.5e-10      70     190 ..     169     291 ..     133     312 .. 0.83

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 4.3e-13
                 EEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB.STHHHHHHHHHHHHTTTE......EEEEEESCGSTHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  70 ylinliDtPGHvdFskevirglrvlDgavlvvdaveG.vepqteevlrlalkegvp......iivfiNKmDrlkaelkeiveevkqklsrkeeklekyg 161
                   i +iD  G +d+s  +   +r  D  + v+d+v+    +q+e+v+++++k++++      +i+++NK+D l+++ +e+v e +++l      ++++ 
  EFC38492.1 169 VMIDVIDPAGIEDYSAMTDYYMRSGDTFINVCDVVDEkTVEQSERVVEQVIKLKCReinyfpVIFALNKVDLLNDSNREQVIEKYTNL------INSII 261
                 5789******************************98846789**********9988777888999********888888888888888......66665 PP

                 HTTT.TTEEEEEEBTTTTBTHHHHHHHHHH CS
    GTP_EFTU 162 ekge.kevpvvfgSalkgegvktllealve 190
                 e+++ k++ ++  Sa++ge+ k l+e +v+
  EFC38492.1 262 ERNQlKNTAIFTSSAKTGENTKLLFEECVR 291
                 55544678999999******9977776654 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.0   0.1   7.2e-12   9.2e-09       9     167 ..     116     285 ..     109     292 .. 0.79

  Alignments for each domain:
  == domain 1  score: 35.0 bits;  conditional E-value: 7.2e-12
                 TT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEE.EEETT..EEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHH CS
         Arf   9 klkkkelrilllGLDnaGKtTilkklkleelvt.tvPTigfnvee.leikn..lkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakee 103
                 ++k  e++i+++G  + GK+ i  +  ++++ +   PT+    ++ l++ n  + + v D  G e    + + Y+++ d+ i v D++d++ +e++++ 
  EFC38492.1 116 WNKVEETKIVMIGAGGVGKSSITINCFHGHFIEfYDPTTDEPYRKlLQVDNlpVMIDVIDPAGIEDYSAMTDYYMRSGDTFINVCDVVDEKTVEQSERV 214
                 556789****************88877777776488*998665551577773357899***************************************** PP

                 HHHHCT..SGCCTTSEEEEEEE-TTSTTSS-HHHH.HHHTTGGG..SS..SSSSEEEEEEBTTTTBTHHHH CS
         Arf 104 Lkalle..eeelkevallvlaNKqDlpealseeel.rellglee..lk..gkrkleiqkcsavkgeglkeg 167
                 ++++++   +e++  +++   NK Dl ++ ++e++ ++  +l +  ++  + ++  i+++sa +ge+ k  
  EFC38492.1 215 VEQVIKlkCREINYFPVIFALNKVDLLNDSNREQViEKYTNLINsiIErnQLKNTAIFTSSAKTGENTKLL 285
                 ***97611568899999999*****9998887776155556655554444556889999999999987655 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.7   2.2e+03     136     184 ..      32      83 ..      17      96 .. 0.49
   2 !   23.7   0.2     2e-08   2.6e-05       1     158 [.     123     275 ..     123     278 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.7
   Gtr1_RagA 136 rkeeireeie.klekeeiqffaTSiwdesly..kAfssivqklipnldvlee 184
                 r++ei+ +i+  l++++++   +S+ + ++y  k + ++ ++ i   ++le+
  EFC38492.1  32 RSQEIKIHIKfILNFQSLNRKISSMPEMTIYfdKFWWKVWETCIGYNPLLEN 83 
                 4444444444323333444444444444444333344444444444444444 PP

  == domain 2  score: 23.7 bits;  conditional E-value: 2e-08
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnl..tlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedlet 97 
                 k++++G +g GK+s+    F+      + +   t+d    ++  ++nl  +++++D  G e++ + +     ++ +r+ +  i V Dv +++  e+ e+
  EFC38492.1 123 KIVMIGAGGVGKSSITINCFHGHF---IEFYDPTTDEPYRKLLQVDNLpvMIDVIDPAGIEDYSAMT-----DYYMRSGDTFINVCDVVDEKTVEQSER 213
                 7999***********999999866...4567788888888887888876689********9998875.....899999999999***998875555555 PP

   Gtr1_RagA  98 l.keilealrqyspeakvfvlihKmDliqedereeifeerkeeireeieklekeeiqffaTS 158
                   +++++   +  +   v   ++K+Dl+++++re+++e+ ++ i++ ie+ + +++ +f++S
  EFC38492.1 214 VvEQVIKLKCREINYFPVIFALNKVDLLNDSNREQVIEKYTNLINSIIERNQLKNTAIFTSS 275
                 5055555444444556677779***************************9998888888887 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.9   0.0   0.00051      0.65      96     117 ..     118     140 ..     107     151 .. 0.83
   2 !   10.0   0.2   0.00048      0.62      44      85 ..     226     266 ..     194     291 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00051
                  HCTTSEEEEECSTTSSHHHH.HH CS
  RsgA_GTPase  96 llkdktsvlvGqSGvGKStL.in 117
                  ++++  +v++G  GvGKS++ in
   EFC38492.1 118 KVEETKIVMIGAGGVGKSSItIN 140
                  5677889************8445 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00048
                  HTT-EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TT CS
  RsgA_GTPase  44 ekgiepvivlnKiDlleeeeeleelkeelealgyevllvsak 85 
                   +  +++ +lnK+Dll++++  e++ e++++l  +++  ++ 
   EFC38492.1 226 INYFPVIFALNKVDLLNDSN-REQVIEKYTNLINSIIERNQL 266
                  344578889**********9.888888887775555544443 PP

>> MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   1.6     6e-06    0.0077      29      88 ..     197     261 ..     192     289 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 6e-06
  MMR_HSR1_Xtn  29 ihnaevliredvt.....vDdlidviegnrvYipclyvlNKiDlisleeldelarepnsvviSae 88 
                   i+ ++v+ ++ v+     v+++i     + +Y p++++lNK+Dl+++++ +++ ++   ++ S  
    EFC38492.1 197 INVCDVVDEKTVEqservVEQVIKLKCREINYFPVIFALNKVDLLNDSNREQVIEKYTNLINSII 261
                   566777666666655555788888888899*****************999999888655555544 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   1.6e-05     0.021       1     114 []     123     237 ..     123     237 .. 0.69
   2 ?   -3.7   0.2       9.5   1.2e+04      15      30 ..     256     270 ..     254     283 .. 0.54

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.6e-05
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETT..EEEEEEECGGCSSHHHHHH.HHHHHHHHHHCTSEEEEEEETT.TTCSHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkg..keielvDtpGliegaseek.glgkaflaleeadlillvvdas.eeklkplde 95 
                 +++ +G   vGKS++    +     ++ +  tT ++ ++ +++++    i ++D +G ie    +   +++ + +  + d ++ v+d+  e+++++ ++
  EFC38492.1 123 KIVMIGAGGVGKSSITINCFHG-HFIEFYDPTTDEPYRKLLQVDNlpVMIDVIDPAG-IE----DYsAMTDYYMR--SGDTFINVCDVVdEKTVEQSER 213
                 5899**********97666664.35678999*****999999887556689******.98....55255555554..4478888888775345666666 PP

                 HHHHHHHH.....TTSEEEEEEES CS
    MMR_HSR1  96 eleellee.....akkplilvlnk 114
                  +e++++      +  p+i++lnk
  EFC38492.1 214 VVEQVIKLkcreiNYFPVIFALNK 237
                 666664324434455556777766 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 9.5
                 HHHHHHTSTEEESSST CS
    MMR_HSR1  15 Linaltgekaivsdkp 30 
                 Lin++++++ + ++++
  EFC38492.1 256 LINSIIERN-QLKNTA 270
                 788888742.223333 PP

>> DUF494  Protein of unknown function (DUF494)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.78   9.9e+02      96     115 ..     208     227 ..     195     229 .. 0.78
   2 ?   13.7   0.1   3.5e-05     0.045      84     144 ..     231     291 ..     217     297 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.78
      DUF494  96 aetrElvidramaldeeels 115
                  e+ E v++++++l+ +e++
  EFC38492.1 208 VEQSERVVEQVIKLKCREIN 227
                 467899*******9998875 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 3.5e-05
      DUF494  84 fllfLeqagvldaetrElvidramaldeeelsledlkwvvlmvlwnqgeekaalileelll 144
                  +  L+++++l+ ++rE vi++  +l ++ ++ ++lk + + +   +  e+  l++ee++ 
  EFC38492.1 231 VIFALNKVDLLNDSNREQVIEKYTNLINSIIERNQLKNTAIFTSSAKTGENTKLLFEECVR 291
                 57889**********************************9999999977777888888776 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   7.1e-05     0.091       1      81 [.     124     210 ..     124     271 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 7.1e-05
                      EEEE--SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHHTTTCEEEEE--T...TTHHHHHHHHHTTSSEEEE-SSGG......G CS
  Sacchrp_dh_NADP   1 vliiGaGsvGqavaellarhfdvdaeitvadrskeklealaakalgvrfeaialda...enyeavLaallkegdlvvnlsppi......s 81 
                      +++iGaG+vG++ +     h+++   i   d++ ++  + + ++ +  + +  +d+   e+y+a+++ ++++gd ++n+   +      +
       EFC38492.1 124 IVMIGAGGVGKSSITINCFHGHF---IEFYDPTTDEPYRKLLQVDNLPVMIDVIDPagiEDYSAMTDYYMRSGDTFINVCDVVdektveQ 210
                      89**************9999999...***********9*999**9999999999963337999999999*********987664444555 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00015       0.2       3      17 ..       8      22 ..       6      23 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00015
                HHHS-HHHHHHHHHT CS
       F-box  3 lsrLPsevlrhILer 17
                +++LPse+l hILe+
  EFC38492.1  8 FLSLPSEILQHILEF 22
                89***********96 PP

>> CM_1  Chorismate mutase type I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.2   0.00023       0.3      12      62 ..     243     293 ..     240     309 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00023
                 SSSHHHHHHHHHHHHHHHHHHTT--GGGEEEEEEEE-TT--SS-CCHHHHH CS
        CM_1  12 enteeeileavkeLleelleeNelkeedivsviftvTkDldaafPaaaaRe 62 
                 + ++e++ e+ ++L+++++e+N+lk++ i +    + ++ +  f   + R+
  EFC38492.1 243 DSNREQVIEKYTNLINSIIERNQLKNTAIFTSSAKTGENTKLLFEECVRRN 293
                 5678999*******************9998776666666666665555555 PP

>> PglD_N  PglD N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   0.00072      0.92       1      34 [.     123     154 ..     123     183 .. 0.76
   2 ?    0.1   0.1         1   1.3e+03      31      58 ..     243     268 ..     213     283 .. 0.66
   3 ?   -1.6   0.0       3.3   4.3e+03      14      36 ..     257     279 ..     252     310 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00072
      PglD_N   1 kivIiGaGGhgkvvadiieangeyeiigflDdnk 34 
                 kiv+iGaGG gk  + i+   g  + i f+D + 
  EFC38492.1 123 KIVMIGAGGVGKSSITINCFHG--HFIEFYDPTT 154
                 79**********9999988777..6677777654 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 1
      PglD_N  31 Ddnkktevegypvlgkaiellkslseee 58 
                 D+n ++ +e+y  l ++i + ++l+  +
  EFC38492.1 243 DSNREQVIEKYTNLINSIIERNQLK--N 268
                 4445556667777777776677763..3 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 3.3
      PglD_N  14 vadiieangeyeiigflDdnkkt 36 
                 +  iie+n+  + ++f+ ++k++
  EFC38492.1 257 INSIIERNQLKNTAIFTSSAKTG 279
                 66788888866666666665543 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.2    0.0047         6       3      18 ..     125     140 ..     123     143 .. 0.86
   2 ?    3.0   0.5     0.076        97      56     126 ..     250     322 ..     170     324 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0047
                 EEESSTTSSHHHHHHH CS
                 xxxxxxxxxxxxxxxx RF
        CbiA   3 iastkGGvGKTtlaan 18 
                 ++ + GGvGK+++++n
  EFC38492.1 125 VMIGAGGVGKSSITIN 140
                 67799*********98 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.076
                 CHCCCHHHHHHCHCHHHH..EEEEEEEEESS...-TTCHHHHHHHHHHC....TS-EEE.EEE--CCHCCCCHHTS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxx.xxxxxxxxxxxxxxxx RF
        CbiA  56 lkrllellealgkkkalllkiagvvlnrvdgeneetllkealeelkqry....gvpvlg.viprdeavaeaparge 126
                 ++++ +l++++ ++++  lk   +     +  ++++ll e + +++ ry    ++ +l+ ++++d++++e+ ++++
  EFC38492.1 250 IEKYTNLINSIIERNQ--LKNTAIFTSSAKTGENTKLLFEECVRRN-RYgsndNLTLLKeIVKYDSKFIEISKKQM 322
                 5666666666666644..4555555555555555777888877777.56688888888899999999999998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1223  (0.0682135); expected 358.6 (0.02)
Passed bias filter:                      553  (0.0308439); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.47
# Mc/sec: 2138.94
//
Query:       EFC38493.1  [L=731]
Description: hypothetical protein NAEGRDRAFT_59498 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-07   31.3   0.1    3.3e-07   29.9   0.1    1.8  1  WH2       WH2 motif
     0.0075   15.8   3.4     0.0075   15.8   3.4    5.5  4  CAP_N     Adenylate cyclase associated (CAP) N terminal


Domain annotation for each model (and alignments):
>> WH2  WH2 motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.9   0.1   3.7e-11   3.3e-07       1      27 [.      25      49 ..      25      52 .. 0.90

  Alignments for each domain:
  == domain 1  score: 29.9 bits;  conditional E-value: 3.7e-11
                X-TCCHHHHHHHHHH..HTTBSS--XE CS
         WH2  1 ggggRgALLadIraGskaqLKKveetn 27
                +++gR++LL+dI++G  a+LKKv+e+ 
  EFC38493.1 25 PSAGRANLLSDINKG--ARLKKVPESE 49
                689************..99*****986 PP

>> CAP_N  Adenylate cyclase associated (CAP) N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   3.4   8.4e-07    0.0075     248     301 ..       3      50 ..       1      58 [. 0.72
   2 ?  -40.8  45.9         2   1.8e+04     235     264 ..     207     241 ..     107     272 .. 0.71
   3 ?  -22.6  25.2         2   1.8e+04     237     257 ..     273     297 ..     253     372 .. 0.66
   4 ?   -4.3  10.8       1.1   9.8e+03     234     268 ..     381     415 ..     358     431 .. 0.44

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 8.4e-07
                 ...XX....XXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
       CAP_N 248 ppPpP....pPppasvfeeesaaasasaaaggmsavFaeLnkGeaiTkgLkkVdksqk 301
                  pPpP    pPpp+       ++ + +a+++g++++++++nkG+    +LkkV +s+k
  EFC38493.1   3 VPPPPvgvsPPPPPT------STVQVKAPSAGRANLLSDINKGA----RLKKVPESEK 50 
                 455666664444442......234568899*************5....8999999998 PP

  == domain 2  score: -40.8 bits;  conditional E-value: 2
                 SSC--XXXXXXX.....XX....XXXXXX.....X CS
       CAP_N 235 aaaaasaaaagg.pppPpP....pPppasvfeees 264
                  ++++s ++ g+ p  PpP    pP p+  ++++s
  EFC38493.1 207 PQPPPSLPSFGSkPSVPPPkgnaPPIPSRGMNNNS 241
                 33333333333322225554432221333333333 PP

  == domain 3  score: -22.6 bits;  conditional E-value: 2
                 C--XXXXXXX....XX.XX...XXX CS
       CAP_N 237 aaasaaaaggpppPpP.pP...ppa 257
                 +a++ +++ g ppP P +P    p+
  EFC38493.1 273 NAPPIPSSRGVPPPIPgKPqstSPP 297
                 2333333333333322122222111 PP

  == domain 4  score: -4.3 bits;  conditional E-value: 1.1
                 .SSC--XXXXXXX....XXXXXXXX.....XXXXX CS
       CAP_N 234 aaaaaasaaaaggpppPpPpPppasvfeeesaaas 268
                 ++++++s +++ + + PpPp  p+ + ++e++a++
  EFC38493.1 381 KSTPPPSIPTKPSMNTPPPPNKPSRTYSQEDEADE 415
                 22333333333332223333333333333322222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (731 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      238  (0.0132746); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.83u 0.25s 00:00:01.08 Elapsed: 00:00:00.49
# Mc/sec: 4466.55
//
Query:       EFC38494.1  [L=784]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-07   31.9   0.8    0.00017   21.8   0.0    2.9  2  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.3    0.0003       5.4       4      55 ..      64     115 ..      62     165 .. 0.70
   2 !   21.8   0.0   9.8e-09   0.00017      44     117 ..     283     381 ..     271     382 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0003
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyn 55 
                 + ++++  rslFr+    e see ++F++ ++e+ ++ ++    k+++++++
  EFC38494.1  64 EAIKNPEFRSLFRKVQSGECSEEPFEFLKMTDEYVASYQSMHSRKEFQAVFS 115
                 5678999*****************************9444444444555443 PP

  == domain 2  score: 21.8 bits;  conditional E-value: 9.8e-09
                 HHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS..........................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS  44 eelkkkakeIyneylapsspkelnidkklreelekrleke..........................qpsrklfeeaqeevfellekdsypkFlkselyl 116
                  +lk  a +Iy+++l+p+s+ +ln+  +  + l++  e                                +lf ++ e+v+  l+ d++p+F++s+  +
  EFC38494.1 283 TKLKHSAGAIYDHFLKPNSSYQLNLGWNKAKILANW-ESIhkqfenligkseevedlqalsdlitrLHPVNLFRDVIEKVHLDLKMDQFPRFVRSNACK 380
                 578889*******************98877666543.3334568999******************978899************************9877 PP

                 H CS
         RGS 117 r 117
                 +
  EFC38494.1 381 T 381
                 6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (784 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1873  (0.104468); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.82u 0.35s 00:00:01.17 Elapsed: 00:00:00.51
# Mc/sec: 4617.75
//
Query:       EFC38495.1  [L=614]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.14   11.7   0.0       0.26   10.8   0.0    1.4  1  DUF900    Alpha/beta hydrolase of unknown function (DUF900)


Domain annotation for each model (and alignments):
>> DUF900  Alpha/beta hydrolase of unknown function (DUF900)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   1.5e-05      0.26      90     143 ..     420     474 ..     406     508 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 1.5e-05
      DUF900  90 kksakkihllaHSmGtwlvlealrqlaieade.paveakikeviLaAPDidvdvf 143
                 ++ +++  ++aHSmG+ +v+ a++   ie d  +  +  i   iL +P  d  v 
  EFC38495.1 420 TNTVRNTIIFAHSMGNLMVAAAISRGLIEIDVkSTSWYNIMGPILGSPLADFGVR 474
                 345778889*************988666666514444477777787776666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (614 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.26s 00:00:00.89 Elapsed: 00:00:00.44
# Mc/sec: 4151.24
//
Query:       EFC38496.1  [L=431]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-90  304.1   1.3    1.3e-90  303.9   1.3    1.0  1  Glyco_hydro_30   Glycosyl hydrolase family 30 TIM-barrel doma
    8.5e-11   41.9   0.0    2.1e-10   40.7   0.0    1.7  1  Glyco_hydro_30C  Glycosyl hydrolase family 30 beta sandwich d


Domain annotation for each model (and alignments):
>> Glyco_hydro_30  Glycosyl hydrolase family 30 TIM-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  303.9   1.3   1.5e-94   1.3e-90       1     348 []      17     357 ..      17     357 .. 0.94

  Alignments for each domain:
  == domain 1  score: 303.9 bits;  conditional E-value: 1.5e-94
                     --EEEEE--HHHHHHHHTS-HHHHHHHHHHHHSTTTT---EEEEEES--SSSSS---ST-STT-TT-TT----HHHHTTHHHHHHH....HHHH- CS
  Glyco_hydro_30   1 ikGfGstlsdasganlkslsdkladlllkqyfsdeGlnlqigrvpiastdfssrvytyddtaddyslanfsltkedtklkipyikr....aqkyn 91 
                     i GfG ++++as+  + +++++++  +l  y+s +Gln+ +gr+p+ s+dfs  +y+ dd+  dy+l+ f++++ d  +k p++ r    ++ +n
      EFC38496.1  17 IIGFGCAMTEASSFVFSTMNEDVKRQILDLYWSPKGLNYTVGRIPMNSCDFSLGTYSCDDVNGDYDLKYFNINR-DKLFKYPLVSRvvnnTRTFN 110
                     569*********************************************************************98.56789998765111166788 PP

                     SS.-EEEEEES---GGGBTTSSSSSS-BBSS-TTS.HHHHHHHHHHHHHHHHHHHTT--ESEEESSSSGGGGGSTT-SSS--B--HHHHHHHHHH CS
  Glyco_hydro_30  92 qd.lkllaapwaapgwlkttkavkGkGalkGkagd.iyhkayakyfvkfleeyaksklsfwglsteneptaGsdkktklqslgftaetqrdfikr 184
                      + lkl+ +pw+ p+w+k +++++G  +  G  ++    +++a y+ k++ +y++ ++ fwgl+ +nep        + ++  +tae+qrdfikr
      EFC38496.1 111 GKpLKLFLSPWSPPAWMKINNDMNGSSTPIGLINEtRILDSWALYYSKYITAYKNLGVPFWGLTVQNEPEFA----APYEACVYTAEFQRDFIKR 201
                     888************************9999765515789*****************************875....6888999************ PP

                     THHHHHHTSTT.TTSEEEEEEEEGGGTTHHHHHHHTSHHHHTTEEEEEEEETTTS-HHHHHHHHHHHSTTSEEEEEEEESS-STTS-SS-TT-HH CS
  Glyco_hydro_30 185 dlGpalaassagknvkllilddnrgnlpkwadvvlndkdaakyvsGiavhayqdaeadkhldethkkfpnvlllgteaseGskskdqsvdyGsfd 279
                      lGp +++     +v++li d nr  +  wa+++ +dk+a+kyv+G a h+y +++  +hl+ +h   p+ +llgtea++G      +v +G++ 
      EFC38496.1 202 HLGPRIKQDHP--EVNILIYDHNRDHVHLWAEIIYADKEASKYVAGTAFHWYVNGQY-EHLTMAHDIAPEKILLGTEATQGP-----RVAFGDWG 288
                     ******99877..9***************************************9875.79********************96.....4899**** PP

                     HHHHHHHHHHHHHHTTEEEEEEEESEB-TTS---TT---B--SEEEEGGGTEEEE-HHHHHHHHHHTTS CS
  Glyco_hydro_30 280 raadyasdildnlnnwvvGwternlvldaeGGpswvsdfvdapviafialaqfykqpmfyalahfskfi 348
                     r++ y  di+++l+n+  Gwt++n +ld+ GGp+ +++++da ++a+   + +y qpm+y ++hfsk++
      EFC38496.1 289 RGESYGFDIINDLENYAQGWTDWNCILDPIGGPTHMQNWCDAAIVANNKTQSIYLQPMYYYMGHFSKYL 357
                     *******************************************************************96 PP

>> Glyco_hydro_30C  Glycosyl hydrolase family 30 beta sandwich domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.7   0.0   2.3e-14   2.1e-10       1      65 []     360     424 ..     360     424 .. 0.85

  Alignments for each domain:
  == domain 1  score: 40.7 bits;  conditional E-value: 2.3e-14
  Glyco_hydro_30C   1 GavRigtsgspsvssnvetvAFlnpDGsivvvilNrsessvtitvsdssk...skgslsvparSivTv 65 
                      G+vRi+++ + ++   + +++F++p++++vv+++N+ ++s+ +++ d s     +++  +p++Si T+
       EFC38496.1 360 GSVRIAHENTLDT---LLVTSFITPENKMVVIVMNQEQTSQIFKLIDMSIgidYAAEMVIPPHSIRTL 424
                      9******998776...*********************9******9987655433345555******96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (431 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       342  (0.0190752); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.24s 00:00:00.74 Elapsed: 00:00:00.41
# Mc/sec: 3187.28
//
Query:       EFC38497.1  [L=493]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-36  126.4   0.6    2.5e-36  125.8   0.6    1.3  1  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  125.8   0.6   1.4e-40   2.5e-36       2     208 ..     208     452 ..     207     453 .. 0.85

  Alignments for each domain:
  == domain 1  score: 125.8 bits;  conditional E-value: 1.4e-40
      DUF563   2 nygHwlvdvlprlllleqlvlddd..drilvpalaspqpfqrell.kllgi.rpekrikveldepvhveklivpvppr...............ssggfq 81 
                  + H + d+ + +l+le++  +++  +++l+++  + + f++ l+   l + rp  + ++ +++pv++e+++++++++               + +++q
  EFC38497.1 208 LF-HAISDFYAGYLILEMFQTKNQklQVVLMDE--HYEGFVDFLWnHTLSVsRPVVKASHFKGRPVRFENALFASSGYatplfsslkdfainqHTCHSQ 303
                 45.*********************666666777..9999999888888***777777777788***************999999999999987777777 PP

      DUF563  82 gallpklrdrlrerlnlekr.kkp....trvlyisR...lkag........sRrilNeeevl....kllpkrgfe..vvdpeslsfeeqiklfssakvi 158
                   l++ ++d++++ ln++kr   +    +++l+isR   +  +         R+i+Ne++v+    k+ ++ +fe   vd+ ++s++eqi+l+++++++
  EFC38497.1 304 VELIRSFADMILSGLNIKKRrA-QqgdlIKILFISRkpyQ--KdgvdhqymARQITNEDDVVnaikKHSRSKEFEvkKVDFVHYSLKEQIELVHNSDFL 399
                 88888**************861.34679********6553..155788888**********9777633333335433899******************* PP

      DUF563 159 vgphGsgltnliFmppg.ttvielvppnrldns..fenlaallglkyayvlge 208
                 +g hG+glt+++F+p+g ++++e+++++rl+ +  fe++++++g+ y++++++
  EFC38497.1 400 IGFHGAGLTHTFFLPEGtSALLEIWNSPRLESWrcFEQITRWKGNAYHLWTNQ 452
                 **************99659*******************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (493 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       582  (0.0324614); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.24s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 3442.91
//
Query:       EFC38498.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-23   82.9   0.2    1.5e-23   82.9   0.2    1.4  2  BolA             BolA-like protein
  ------ inclusion threshold ------
      0.066   13.2   0.5      0.098   12.7   0.5    1.2  1  Frankia_peptide  Ribosomally synthesized peptide prototyped b


Domain annotation for each model (and alignments):
>> BolA  BolA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.9   0.2   1.6e-27   1.5e-23       1      76 []      13      95 ..      13      95 .. 0.94
   2 ?   -3.6   0.0       1.6   1.4e+04      45      55 ..      99     109 ..      97     116 .. 0.62

  Alignments for each domain:
  == domain 1  score: 82.9 bits;  conditional E-value: 1.6e-27
        BolA  1 LtealkpehlevedeShkhagha.......eaggetHFkvvivseaFegkslvarhRlvyalLkeelakgiHALslktktpee 76
                Lt++++p +l++++ S+  ++         +agge+H++++ivs++Feg+++v+rhR++++++++e+++g+HAL++++kt+ e
  EFC38498.1 13 LTNQFSPIKLSIKNISKPYENDGahndifkQAGGESHLRITIVSDNFEGQTMVKRHRMIHKAISDEFRDGLHALTIHAKTQYE 95
                799*************98877667789999999***********************************************876 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.6
        BolA  45 lvarhRlvyal 55 
                 +++r R + + 
  EFC38498.1  99 SLERMRKIRED 109
                 56777777654 PP

>> Frankia_peptide  Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.5   1.1e-05     0.098       4      60 ..      69     124 ..      67     126 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.1e-05
  Frankia_peptide   4 rlIgrAvtDeaFRqrLladpeeavkeagYdltpeElqalekadadsleavalglder 60 
                      r+I +A++D +FR  L a    a  +++Y+ + e +++++++  d+ +     +de+
       EFC38498.1  69 RMIHKAISD-EFRDGLHALTIHAKTQYEYNQSLERMRKIREDREDEINEDEDIMDED 124
                      89******9.5*****************************99999988766666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1064  (0.0593452); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.26s 00:00:00.66 Elapsed: 00:00:00.41
# Mc/sec: 954.90
//
Query:       EFC38499.1  [L=309]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.011   16.6   0.2        2.6    8.9   0.1    2.5  2  Corona_NSP4_C  Coronavirus nonstructural protein 4 C-terminus


Domain annotation for each model (and alignments):
>> Corona_NSP4_C  Coronavirus nonstructural protein 4 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.1   0.00014       2.6      16      62 ..      88     135 ..      74     140 .. 0.81
   2 ?    5.1   0.0    0.0022        40      28      63 ..     251     288 ..     224     304 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00014
                    HS-EEE-HHHHHHHHTTT-HHHHHHHHHTHHHH.HS-EEE--HHHHHH CS
  Corona_NSP4_C  16 lstfvidkesyvkLkneisldklkrylslynky.kyysGkldeadyre 62 
                    +s f   ++ +  Lk++ s+  + ++ + y ky k + G++de +y+ 
     EFC38499.1  88 KSKFSSIHKAHFALKKSFSKLTILSHENIYKKYsKLFVGEVDECSYKD 135
                    4555555566778999999999**********9889**********85 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0022
                    HHHTTT-..HHHHHHHHHTHHHHHS-EEE--HHHHHHH CS
  Corona_NSP4_C  28 kLkneis..ldklkrylslynkykyysGkldeadyrea 63 
                    +L n+i   +++  +yl+ y k + y G+ de++ +e+
     EFC38499.1 251 RLSNSICgyPEHSLTYLNKYIKIHVYLGERDENNLLES 288
                    577776522466678****************9988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       662  (0.0369234); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1900.60
//
Query:       EFC38500.1  [L=299]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.9e-19   67.2   0.0    1.6e-18   66.3   0.0    1.5  1  Alba       Alba
    7.2e-05   22.8   2.3    7.2e-05   22.8   2.3    3.4  3  Rpp20      Rpp20 subunit of nuclear RNase MRP and P
  ------ inclusion threshold ------
      0.049   11.6   8.3      0.076   11.0   8.3    1.2  1  Dicty_REP  Dictyostelium (Slime Mold) REP protein


Domain annotation for each model (and alignments):
>> Alba  Alba
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.3   0.0   2.6e-22   1.6e-18       1      65 [.      34     111 ..      34     113 .. 0.96

  Alignments for each domain:
  == domain 1  score: 66.3 bits;  conditional E-value: 2.6e-22
                 CEEEE-STS-HHHHHHHHHHHH..............THTTESEEEEEEETTHHHHHHHHHHHHHHHTCTT.EEEEEEEE CS
        Alba   1 neiyVsskspimsyvkralklL..............snkkeeeVvlkatGraIskAvsvaeilkrrfgkglyqvnvlts 65 
                 nei+++   + ++y+++a+ lL               ++ +++Vvlka+G+aI+kAv++ae+lkrr+ +gl+q++ + s
  EFC38500.1  34 NEIRITAQGRSRNYISYAVGLLdptllqkeekdvqtPSEPFDTVVLKAMGKAIQKAVTIAEVLKRRV-AGLHQITSIES 111
                 89******************************99997799***************************.7******9987 PP

>> Rpp20  Rpp20 subunit of nuclear RNase MRP and P
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.1      0.13   7.5e+02      44      72 ..      16      44 ..       3      48 .. 0.70
   2 !   22.8   2.3   1.2e-08   7.2e-05      55     136 ..      68     139 ..      58     140 .. 0.73
   3 ?   -3.3   3.8       1.4   8.2e+03      37      37 ..     214     214 ..     180     255 .. 0.51

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.13
       Rpp20 44 eekkklealekkeeelkkeeVfvkatGrA 72
                +  +    ++++++e +k+e+ + a Gr+
  EFC38500.1 16 SATGGSGVSNNNNNEIQKNEIRITAQGRS 44
                44444555667777889999999999986 PP

  == domain 2  score: 22.8 bits;  conditional E-value: 1.2e-08
       Rpp20  55 keeelkkeeVfvkatGrAiekalsvgrwfqeke.eykvrvetgsVevvDdivedeeekankaaededeeepetrtRwvsmvev 136
                 ++ ++  + V++ka+G+Ai+ka+ +++ ++++  +++   + +s e+ D ++ +           e++ +  t++R+vs++ +
  EFC38500.1  68 QTPSEPFDTVVLKAMGKAIQKAVTIAEVLKRRVaGLHQITSIESQEIEDQYEPK-----------EEGMDVVTKKRTVSSIVI 139
                 445567899********************8774455555555555555555555...........488899999999999876 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 1.4
       Rpp20  37 a 37 
                 +
  EFC38500.1 214 T 214
                 1 PP

>> Dicty_REP  Dictyostelium (Slime Mold) REP protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   8.3   1.3e-05     0.076     241     301 ..     195     252 ..     182     277 .. 0.55

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.3e-05
   Dicty_REP 241 ntqrensqpskeknkttttttttttttsqartrkrkaidddklsenqakekkknskksddd 301
                  t+++++q+++   +ttttt+ttttt   a+tr+ ++ ++++ +++q+   + +++++ + 
  EFC38500.1 195 ATRKQQQQQQTGGEATTTTTATTTTT---ATTRQPRQRNPETAQQQQQTGGTAQTSGAAQT 252
                 33444444444433333333333333...33444444467777776666666555555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1548  (0.0863406); expected 358.6 (0.02)
Passed bias filter:                      543  (0.0302861); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.43
# Mc/sec: 2070.72
//
Query:       EFC38501.1  [L=466]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-37  128.9   7.0    3.7e-37  128.5   7.0    1.1  1  Serpin    Serpin (serine protease inhibitor)


Domain annotation for each model (and alignments):
>> Serpin  Serpin (serine protease inhibitor)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.5   7.0   2.1e-41   3.7e-37       9     368 ..      58     463 ..      50     465 .. 0.79

  Alignments for each domain:
  == domain 1  score: 128.5 bits;  conditional E-value: 2.1e-41
                 HHHHHHHHHS...TTSSEEE-HHHHHHHHHHHHHTB-HH..HHHHHHHHH.TGCCHCHHHHHHHHHHHHHHHCS...SGGTSEEEEEEEEEEEETTSEB CS
      Serpin   9 dlfkalskek...pskNiifSPlsistaLallllGakge..taeellevL.glnesdeeelhealekllsrlne...seekdkelkianglfvekglkl 98 
                 +++++l  ++     +N++fSP+s+  +L+++l+  +++   + el ++L +    +  el+++++++++  +e    ++++ +l +  +lf ++++  
  EFC38501.1  58 KIMRNLITNSimdHFQNVMFSPISLGYSLSVILEACEKDdpKRGELTTLLsK---FNLGELKNSMQSIVEFSHEtdmLNDEKARLILTPALFASEEFLA 153
                 5555555555555689****************99998772245566676633...4444544555555444444444556899**************** PP

                 -HHHHHHHHHHHS-EEEEE-TTTHHH...HHHHHHHHHHHHTTTSSSSSSSTTSS-TTECEEEEEEEEEEEEBSS--BGGGEEEEEEE...SSS...SE CS
      Serpin  99 keeflklakklykaevesvdfkddee...arkkINswvekqTngkIkdllsegsidsdtrlvlvNaiyFkGkWeepFqpeatreekFy...vne...ge 188
                 k  f+k+   + +  ++s +f++de+   +rk +N+ ++++ n+  + ++  g i++ t+++ +++  F GkWe+pF+ ++t+ e F+     +    e
  EFC38501.1 154 KTGFKKDNLYMKNLLIQSCNFTTDEAaneSRKMMNRIISEKNNETTTAFIGTGFITNATQAIYADTGLFVGKWEKPFDLNDTSIELFRvisSADedvVE 252
                 *********************9876433689*********************************************************55422222233 PP

                 EEEEEEE.EEEEEEEEEEETTTTEEEEEEEBGG.SEEEEEEEESSTTT.HHHHHHHHSHHHHHH.....HHHHGEEEEEEE..EEEEE-EEEEEEEEHH CS
      Serpin 189 kvkvpmM.sqegkfkyaedeelnakvlelpYkg.nlsmlillPdeekg.leelekkltaerlee.....wlsklkmkkeke..evslPkfkieesidlk 277
                  ++++mM ++++ f+++e++  n++ ++l+Yk+  +sml+++P++  +   + e+++++  +++      +s   ++kek   ++s+Pkf++e++ ++ 
  EFC38501.1 253 YIEIEMMnQHNSSFEHGEQK--NFQWIKLKYKDaPYSMLFIVPKDALSlYGDSEERFNR-FVNRqldsgCISCSFPTKEKFfkKISIPKFRVESKSKIS 348
                 4489***6667888877755..*********99899*******6565657788888873.333333334334344444554689*************** PP

                 HHHHH..TTHCGGGSTTTB.BTTTB....................SSSSEEEEEEEEEEEEEESSSEEEEEEEEEE..CCTTCS-SSCEEEEECSEEEE CS
      Serpin 278 evLqk..lGlkdlFseneadlsgis....................kkeplfvsevlhkafievnEeGteaaaatav..atllskksspvefkvdrPFlf 352
                  +L++  +   +lF + e + +++                      +e  +++e++hk++ie +E Gt   + t +  +   ++++++ +f++drPF f
  EFC38501.1 349 GLLRAktFSAPSLFPKVEPKKKKVNstqtnetapvevpptqtettVPEFWRLNEFFHKTVIEFSELGTVEGEITPEnaKLVEEREQDDSNFVLDRPFAF 447
                 ***871145568999888888888899*************9986544889************************94435566778899*********** PP

                 EEEETTTTEEEEEEEE CS
      Serpin 353 lireektgliLFlGkv 368
                 ++++e+t++ + +Gk+
  EFC38501.1 448 ILHHEPTNSAVLVGKI 463
                 **************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (466 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       630  (0.0351386); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2899.92
//
Query:       EFC38502.1  [L=199]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.6e-12   46.3   0.6    3.6e-12   46.3   0.6    1.8  2  B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domai
  ------ inclusion threshold ------
      0.015   15.8   4.0      0.024   15.2   4.0    1.2  1  ArdA            Antirestriction protein (ArdA)
      0.052   13.2   3.8      0.078   12.6   3.8    1.4  1  RabGAP-TBC      Rab-GTPase-TBC domain


Domain annotation for each model (and alignments):
>> B2-adapt-app_C  Beta2-adaptin appendage, C-terminal sub-domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.23   1.4e+03       4      26 ..      33      55 ..      30      74 .. 0.76
   2 !   46.3   0.6   6.1e-16   3.6e-12       8     110 ..      86     189 ..      82     190 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.23
  B2-adapt-app_C  4 gkldreeFlekWkslpesneqsl 26
                     ++d +eF e  ++l  +n+q++
      EFC38502.1 33 DEIDTDEFMESSQALYYTNQQKH 55
                    57888999999999888877765 PP

  == domain 2  score: 46.3 bits;  conditional E-value: 6.1e-16
  B2-adapt-app_C   8 reeFlekWkslpesn.eqsltlsnnv.as.tspdaleekLqanniftiAkrgvegqqeklYfsakltngilfLvellintsgksvkvsvKsedpe 99 
                      ee++++Wk++ + +   ++++ ++   + +  ++l + L++ +i+t+A +gv+ +  ++Y +++ tn+i++L+e +in++ + +kv +K +++e
      EFC38502.1  86 TEEYKTLWKQFGDMHvTLEYSVLDKSaENdQIKSDLDNLLESFHIYTLA-SGVNVNSITFYNYCESTNNITYLIETTINETRT-AKVRIKYSSNE 178
                     689*********655256777777663445667899*************.***999***********************7776.*********** PP

  B2-adapt-app_C 100 vaplflqlles 110
                      ++ f++++e+
      EFC38502.1 179 GLNNFVNYFEN 189
                     ********997 PP

>> ArdA  Antirestriction protein (ArdA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   4.0     4e-06     0.024       8     140 ..      48     186 ..      45     190 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 4e-06
        ArdA   8 kYnnGelhGeWldlpadaeelqealkaisaeeedeEwaihDyeglpeaslge......yesidelnelaklleeleehgeafaawvehfg.dleeleda 99 
                 +Y+n + hGe ++ + d+e+  e +++i ++++ +E+   +y +l  +++g       y+ +d+ +e  +++++l++  e f +++   g +++++   
  EFC38502.1  48 YYTNQQKHGESFHHSEDEEKSIELISQIRMNQNVKEYSTEEYKTLW-KQFGDmhvtleYSVLDKSAENDQIKSDLDNLLESFHIYTLASGvNVNSIT-- 143
                 69*************************97779999********663.44554455567999999999998888888877888888877765655554.. PP

        ArdA 100 feeeylgeydsledyAeelveelgllk...eeeipeslenYfDy 140
                   ++y+++ ++++ + e+ ++e+  +k   ++  +e l+n+++y
  EFC38502.1 144 -FYNYCESTNNITYLIETTINETRTAKvriKYSSNEGLNNFVNY 186
                 .489********************99998657778888888777 PP

>> RabGAP-TBC  Rab-GTPase-TBC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   3.8   1.3e-05     0.078      19     108 ..      64     165 ..      41     198 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.3e-05
  RabGAP-TBC  19 krlkksekkqeksekeksklekseeske.lsqIkkDvprtfpes...esfknkqgqnqLeriLkaysiynpevg..........YcqGmndivaplllv 103
                 +++k+ e  ++ +++++ k+++ ee k+ ++q   D++ t+  s   +s +n+q++++L ++L  ++iy  + g          Yc   n i  ++  +
  EFC38502.1  64 DEEKSIELISQIRMNQNVKEYSTEEYKTlWKQF-GDMHVTLEYSvldKSAENDQIKSDLDNLLESFHIYTLASGvnvnsitfynYCESTNNITYLIE-T 160
                 556677778888899999999999999955555.79*****933466999999******************98888888888888888888765544.4 PP

  RabGAP-TBC 104 sldee 108
                 + +e+
  EFC38502.1 161 TINET 165
                 44444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (199 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1428  (0.0796475); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1314.80
//
Query:       EFC38503.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       633  (0.0353059); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.40u 0.28s 00:00:00.68 Elapsed: 00:00:00.43
# Mc/sec: 1260.00
//
Query:       EFC38504.1  [L=1031]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      2e-47  162.1  23.2      2e-47  162.1  23.2    2.3  2  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t
    3.8e-14   53.5   0.0    1.6e-07   31.9   0.0    3.2  2  Hydrolase        haloacid dehalogenase-like hydrolase
    2.3e-10   40.3   2.8    2.6e-10   40.1   0.0    2.4  2  E1-E2_ATPase     E1-E2 ATPase
    4.9e-06   26.5   0.0    3.3e-05   23.9   0.0    2.2  2  Cation_ATPase    Cation transport ATPase (P-type)
     0.0033   17.2   0.6      0.017   14.9   0.0    2.4  3  Hydrolase_3      haloacid dehalogenase-like hydrolase


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   2.8      0.11   3.8e+02     168     235 ..     201     270 ..     192     290 .. 0.67
   2 !  162.1  23.2   5.5e-51     2e-47       2     203 ..     772     975 ..     771    1027 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.11
  PhoLip_ATPase_C 168 kvaletktwtliliililg.sillyflflllyssllps...ssefygvleelfsspsfwlvlllvvvvallp 235
                      k+ l  k  ++ ++ +++g  +++ + f+ +++s++ +   +  ++g+ e+++s+ sf ++ +l+ ++++  
       EFC38504.1 201 KFSLVNKMLNI-MVGIMFGiQMICCLSFT-AVKSYYEFrerTEFYLGNRERTISDGSFVVLAFLSHIIMFAH 270
                      55555555554.44444442666666666.555656666866666778999999999999988887777543 PP

  == domain 2  score: 162.1 bits;  conditional E-value: 5.5e-51
  PhoLip_ATPase_C   2 raSDyaiaqFrfLkrLLlvhGrwsyrRisklilyffyKnvvftlvqfwfqfyngfsgqslyeswlltlynllftslpvivlgifdqdvsaelll 95 
                      ++SD+ai++Fr+LkrLL+vhGr+sy+Ri+ +i y +y n+ ++++q++++f+ +fsgqsl e+++ +l  l+f  l+++ +gif++d+s+++l+
       EFC38504.1 772 MSSDFAIPKFRMLKRLLVVHGRYSYKRIADFIHYYIYINLGIVFIQIIYAFFVQFSGQSLNEDFVTILSTLFFMQLNPLSFGIFEKDISEKYLE 865
                      89*****************************************************************************************998 PP

  PhoLip_ATPase_C  96 ky...PelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvaletktwtliliililg 186
                      +    P lYkl++k+++fnl tf++wi  g+++ +iiffl+++++d+  f++gk+++++   +lv+++++lvv lk +le++++  ++++++l 
       EFC38504.1 866 DAkhgPILYKLLRKENIFNLYTFVKWIGGGMLHMTIIFFLCMYSTDSCLFTNGKDDGFWVKVVLVTSCSFLVVHLKSFLEFQFVR-LHHFTFLQ 958
                      87777***************************************************************************99664.33333333 PP

  PhoLip_ATPase_C 187 sillyflflllyssllp 203
                       ++++ l++  + ++l 
       EFC38504.1 959 FLFVWALSMDSIGYMLV 975
                      23333333322222111 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.9   0.0     0.002         7       1      24 [.     329     352 ..     329     382 .. 0.81
   2 !   31.9   0.0   4.3e-11   1.6e-07      73     210 .]     559     757 ..     518     757 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.002
                 SSEEEEESBTTTBCHHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase   1 iktvvfDkdGTLttgepsvedviv 24 
                 i+ ++ Dk+GTLt+ ++  +++ +
  EFC38504.1 329 IDMIFSDKTGTLTENSMIFKKCCA 352
                 68899*********9998777655 PP

  == domain 2  score: 31.9 bits;  conditional E-value: 4.3e-11
                 HHHHHHHH.....HCHHHHHHHHHHHHHHCHHHHHHTTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHHHHHHHTT.....GGGE. CS
                 xxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxx. RF
   Hydrolase  73 kpewltal.....dippdlgaaigsaqsqgrtvallqaralavftiadplkvkpeaaeavasLkaagievvlltgdnpetaeraanqlG.....ddyf. 160
                    wlt        i++  ++ai+ ++sq +     + ++++  +++d+  + + + e++  L +agi v++ltgd +eta ++a  +G      + f 
  EFC38504.1 559 AINWLTNYnsvqsFISKSRKEAIENCESQLEK----DLEIVGCTAVEDT--LQDQVPETISFLIEAGIHVWMLTGDKRETAFKIAGIAGlihehSQVFt 651
                 45577777666666777777777777777766....3477*********..**************************************9966633332 PP

                 .SEEEEHHCES.STTT.....................................................SHHHHHHHHHHHTST.GGGEEEEESSHHHH CS
                 .xxxxxxxxxx.xxxx.....................................................xxxxxxxxxxxxxxx.xxxxxxxxxxxxxx RF
   Hydrolase 161 .daviasdiet.vakp.....................................................spegkvaaireLqgk.peevamVGDgvnDa 203
                  d+ ++s+++   + +                                                      p++k +++   ++k +++++ +GDg+nD+
  EFC38504.1 652 lDGDLGSITSNeEGDVkvceiltliqslssenqkeivlvldghaftfcsssrnfeslvskcktvvfcrsTPKQKSQLVHFAKIKlGKRILSIGDGINDV 750
                 44444444444744446688899999999999999999999999999999999999999999999999999999999999998889999********** PP

                 HHHHHTT CS
                 xxxxxxx RF
   Hydrolase 204 aalaaAg 210
                 +++++A+
  EFC38504.1 751 PMIQQAN 757
                 *999996 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.1   0.0   7.2e-14   2.6e-10       3     168 ..      47     281 ..      45     289 .. 0.81
   2 ?   -2.0   0.7       0.6   2.1e+03     117     155 ..     801     842 ..     796     845 .. 0.60

  Alignments for each domain:
  == domain 1  score: 40.1 bits;  conditional E-value: 7.2e-14
                   S--EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.....EEE-TTTS---S-EE-.............................. CS
  E1-E2_ATPase   3 lpptakvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa.....evdesaLTGEslpvek.............................. 64 
                   +++ + v+r+++ ++i++ ++++GDiv++ +g++ paD +++ +s+     ++++s L GE    ++                              
    EFC38504.1  47 NQANTLVLREEQFVKIETGKVRVGDIVQVDQGQIFPADLILIGSSQedsccKIETSNLDGETSLKSRfpptlsklfnnvaslkglggiikcqepnes 143
                   67788999**********************************9776666799**************9****************************** PP

                   ..................G-TTEE-TT-EEEE-EEEEEEEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSS CS
  E1-E2_ATPase  65 ..................ekgdmvfsGtvvvsgeakavVtatgedtelgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgks 143
                                       ++ +  G+      a ++V+ tg+dt+     + ++++ s k++l++k+ +++  +++ + +i++l f +  ++ ++
    EFC38504.1 144 lnkfigsitvdgheqvplFHQNLLLKGCKLSTEIAYGIVIYTGKDTKS---LKNMNRT-SVKFSLVNKMLNIMVGIMFGIQMICCLSFTAVKSYYEF 236
                   ************998888799************************975...4555555.66788888888877777776666666666555443333 PP

                   TT....................HHHHHHHHHHHHHS-TTHHHHHH CS
  E1-E2_ATPase 144 la....................eallralallvaaiPcaLplavp 168
                                          a+l+ + ++   iP  L + + 
    EFC38504.1 237 RErtefylgnrertisdgsfvvLAFLSHIIMFAHLIPVSLLVSFE 281
                   333456666666666777766666777777777777777766655 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.6
                   HHHHHHHHHHHHHHHHHHHS-STTTSSTT...HHHHHHHHHH CS
  E1-E2_ATPase 117 klgkvlvpvvlliallvflialllgksla...eallralall 155
                    ++ +++ + l i+++ +++a++++ s +   e ++ +l++l
    EFC38504.1 801 DFIHYYIYINLGIVFIQIIYAFFVQFSGQslnEDFVTILSTL 842
                   566677776666666666666665554443337777777665 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.0   9.1e-09   3.3e-05       2      82 ..     395     514 ..     394     519 .. 0.80
   2 ?   -1.0   0.0      0.53   1.9e+03      15      29 ..     621     635 ..     613     641 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 9.1e-09
  Cation_ATPase   2 lcNsaaf...sensekdevkllGnktEsALlvlaeklgldteelree............tkkvqeipFnssrKrmsvvlkle.............. 68 
                    lc++ ++   ++++e++++    + +E+AL+  a + + + + + e+            +++++eipF+ +rKrms+++kl+              
     EFC38504.1 395 LCHNVSLrkiRKDNEDEVFYEGESIDEVALVLGAMNNQFELKYFSEKktilsifgkeysFERIAEIPFSPKRKRMSTLFKLSleflndfpiyyhia 490
                    677777666556666666666677899***99999997888888777888888888888**********************999999999999999 PP

  Cation_ATPase  69 ..........pekkvrlyvKGApe 82 
                              + + v+++ KGA  
     EFC38504.1 491 tekygiapdeSGQLVICFSKGADS 514
                    999999987666667788888865 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.53
  Cation_ATPase  15 devkllGnktEsALl 29 
                    +++ l+G+k E+A  
     EFC38504.1 621 HVWMLTGDKRETAFK 635
                    7899********975 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1      0.51   1.8e+03     144     184 ..     546     586 ..     476     613 .. 0.63
   2 ?   -2.3   0.0      0.85     3e+03      15      42 ..     603     630 ..     598     643 .. 0.76
   3 !   14.9   0.0   4.8e-06     0.017     204     227 ..     738     761 ..     724     779 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.51
                  EEEEES-HHHHHHHHHHHHHHCTTTEEEEEESTTEEEEEET CS
  Hydrolase_3 144 kililkdkekldelekelksklnklltitssskgyleimpk 184
                   +l++++  +++e++++l++ ++ +  i++s k  +e  + 
   EFC38504.1 546 TLLFCFKFVDSNEAINWLTNYNSVQSFISKSRKEAIENCES 586
                  44455555555555555555554444555555555443333 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.85
                  ---HHHHHHHHHHHHTTSEEEEE-SS-H CS
  Hydrolase_3  15 kisektkeaikklkekgikvviATGRsl 42 
                  +++++  e+i  l+e+gi+v   TG + 
   EFC38504.1 603 TLQDQVPETISFLIEAGIHVWMLTGDKR 630
                  5677778888888889998888888655 PP

  == domain 3  score: 14.9 bits;  conditional E-value: 4.8e-06
                  GGEEEEESSGGGHHHHHHSSEEEE CS
  Hydrolase_3 204 eeviafGDgeNDieMLeaaglgvA 227
                  ++++++GDg ND++M+++a++gv 
   EFC38504.1 738 KRILSIGDGINDVPMIQQANVGVG 761
                  6799***************99985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1031 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       813  (0.0453455); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.76u 0.26s 00:00:01.02 Elapsed: 00:00:00.44
# Mc/sec: 7008.29
//
Query:       EFC38505.1  [L=751]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0014   18.2   0.3     0.0026   17.3   0.3    1.4  1  Sgf11         Sgf11 (transcriptional regulation protein)
  ------ inclusion threshold ------
        7.7    6.5   7.7         11    6.0   3.7    3.2  2  ResIII        Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> Sgf11  Sgf11 (transcriptional regulation protein)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.3   2.9e-07    0.0026       3      26 ..     148     171 ..     146     177 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 2.9e-07
                 -EEE-TTTSSEEEGGGHHHHHHHH CS
       Sgf11   3 eyvtCpnCgRqiaasRFApHLekC 26 
                 +yv+C+ C + +++  +  HL+kC
  EFC38505.1 148 KYVNCDECHKLVSGPKYTRHLNKC 171
                 79********************** PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   3.7    0.0012        11      97     157 ..     108     171 ..       7     180 .. 0.60
   2 ?   -1.1   0.1      0.19   1.7e+03      78     118 ..     230     267 ..     192     286 .. 0.61

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0012
                 .......-SEEEEEHHHHHHTH.............HHHTTT-SEEEEETGGGTTS.TTTHHHHHT- CS
      ResIII  97 kekdstnkkilvttiqsldadseee.....eeeseellrdrfdviiiDEaHrlgakkswreilekf 157
                  +k + +++i+++ ++  ++++  +     e +++++ + + +++ +DE+H+l +  ++++ l+k+
  EFC38505.1 108 GRKIKYENSICLECEENNHKSQ--GgiwcyELDHHKNNKRAPKYVNCDECHKLVSGPKYTRHLNKC 171
                 2223334555555555544444..2579855555666666666************99999866665 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.19
                 TGG....GEEEESSS-B--.......-SEEEEEHHHHHHTH CS
      ResIII  78 lseaykeigkkvsgdkkkakekdstnkkilvttiqsldads 118
                   ++++  +++++ +++  +++++++ ++++ + +++++++
  EFC38505.1 230 NRNDTQ-SNGSITINNQ--QNNQQSKPRVILGNPSQFNQNN 267
                 222211.1111111111..2234566666666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (751 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1401  (0.0781416); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.31s 00:00:01.05 Elapsed: 00:00:00.50
# Mc/sec: 4486.79
//
Query:       EFC38506.1  [L=441]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0028   17.0   1.7     0.0028   17.0   1.7    2.6  3  FAM76      FAM76 protein
     0.0055   14.7   0.6       0.66    7.9   0.2    2.2  2  Prominin   Prominin
     0.0097   15.0   0.2      0.015   14.4   0.2    1.3  1  TMEM192    TMEM192 family
  ------ inclusion threshold ------
      0.042   14.2   1.7       0.38   11.1   0.4    2.6  2  DUF2183    Uncharacterized conserved protein (DUF2183)
      0.049   14.2   0.6        0.1   13.1   0.6    1.6  1  APG6_N     Apg6 coiled-coil region
      0.049   14.1   0.1       0.14   12.7   0.1    1.7  1  DUF16      Protein of unknown function DUF16
       0.18   12.3   2.3       0.51   10.8   2.3    1.8  1  FlaC_arch  Flagella accessory protein C (FlaC)


Domain annotation for each model (and alignments):
>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1       0.7   1.8e+03     201     247 ..      44      92 ..       4      98 .. 0.45
   2 !   17.0   1.7   1.1e-06    0.0028     147     277 ..     123     265 ..     104     273 .. 0.55
   3 ?   -2.2   4.7      0.82   2.1e+03     145     217 ..     298     342 ..     272     357 .. 0.36

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.7
       FAM76 201 esnetskksldsnssdhlvavtqLkeeiaslkkqle..qkdqellekdk 247
                     +s k  +sn+s++l+a t+    +++  +q++  ++d+++ + ++
  EFC38506.1  44 LPPPASFKYFNSNTSNQLLATTNSDMMMNRAAHQMDgfSQDSNMFSNNR 92 
                 2223334466777777777776666666555555542245555555555 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 1.1e-06
       FAM76 147 skskkkkskskkskkskekskekkaskkkskkhkkrssrlevskleeek.............laeekesnetskksldsnssdhlva...vtqLkeeia 229
                 +++++++ + + ++++++ s+++ ++ ++++k ++ s+   vs  +  +             +++++++n+++ +  ++  +  +va   ++ L e+i 
  EFC38506.1 123 TQNNTATPHVSMHSNQRQVSDDNVSHISSQRKYETYSN--TVSYPC--RtavdspngffaclQSSTNSRNNSRPQYQHAPHTPTIVAdqnLSPLFERIS 217
                 12222222222222222222222222222222222222..222222..02233444566654333333334444444555555666522267788**** PP

       FAM76 230 slkkqleqkdqellekdkkitelkaellekekelreklkelekeakek 277
                 +l+kqle++ +++++ +++  +l+ +  e+ek+l++ +++++  +++ 
  EFC38506.1 218 QLEKQLERQSVMIIDLERENNSLRYQINESEKRLNSAVSNSHVLHSNA 265
                 ***********************************9999988777665 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.82
       FAM76 145 krskskkkkskskkskkskekskekkaskkkskkhkkrssrlevskleeeklaeekesnetskksldsnssdh 217
                  +s  ++ +s +k sk+sk +sk                            +++ ++sn+ts + +d +  dh
  EFC38506.1 298 VSSPVSNGSSYEKPSKSSKLSSK----------------------------QTSVSSSNGTSFSIVDESEKDH 342
                 11111222222222222222221............................2222333333333333333333 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.3   0.0    0.0016         4     704     779 ..     106     181 ..      25     184 .. 0.71
   2 !    7.9   0.2   0.00026      0.66     240     300 ..     208     270 ..     200     289 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0016
    Prominin 704 aenflkkngseiin.neskklldrileqfeeYidwvieevtenvgkCkPlayildsgvvllCerlvdPlNaFWfgll 779
                 +++fl++  s++ + + +++ +++ +  +++  + v ++   ++ + +  ++ + ++v + C+  vd+ N+F  +l 
  EFC38506.1 106 LKEFLQETYSSYPShTNTQNNTATPHVSMHSNQRQVSDDNVSHISS-QRKYETYSNTVSYPCRTAVDSPNGFFACLQ 181
                 5666666666664413345555555555666666666666666655.555789*********************986 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00026
    Prominin 240 elerllenlkeakeqLeqvnklekeLrksgsqLrdglrgvkrdlnqalsn..lCqseeCskil 300
                 +l  l+e +++ ++qLe  + +  +L  + + Lr  +++  ++ln+a+sn  + +s+ C ++ 
  EFC38506.1 208 NLSPLFERISQLEKQLERQSVMIIDLERENNSLRYQINESEKRLNSAVSNshVLHSNACADLP 270
                 577899*******************************************97344469998865 PP

>> TMEM192  TMEM192 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.2     6e-06     0.015     201     233 ..     213     245 ..     194     247 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 6e-06
     TMEM192 201 frdgssleellekQadlIryLkqhnakLsrril 233
                 f+  s+le++le+Q+ +I  L ++n++L+ +i 
  EFC38506.1 213 FERISQLEKQLERQSVMIIDLERENNSLRYQIN 245
                 67789***********************99886 PP

>> DUF2183  Uncharacterized conserved protein (DUF2183)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.4   0.00015      0.38       4      60 ..      95     151 ..      93     158 .. 0.77
   2 ?    1.1   0.0       0.2     5e+02      18      52 ..     383     418 ..     370     428 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00015
     DUF2183   4 vSaspwnlyplleeFleenglPkgslllrdlsltlksllkek.staehKraeiekile 60 
                 +Sasp+++ p l+eFl+e+ + + + +++  + t++  ++ + ++++   +++++i +
  EFC38506.1  95 LSASPVSVLPNLKEFLQET-YSSYPSHTNTQNNTATPHVSMHsNQRQVSDDNVSHISS 151
                 8*****************9.99999999998855555555333667777777776655 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.2
     DUF2183  18 FleenglPkgslllrdlsltlksllkek..staehKr 52 
                  + +n++P+ s++l  ++ + k l+ke+  ++++ K+
  EFC38506.1 383 LF-QNKYPEKSCKLVLCNEDYKALFKENfnRSNSEKK 418
                 33.566********99999999999966553333333 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.6   4.1e-05       0.1      44      92 ..     189     252 ..     111     260 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 4.1e-05
      APG6_N  44 k...............qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeele 92 
                 +                d++l  l e++++lek+ e+    + +le+e+ +l+ ++++ e+ l+
  EFC38506.1 189 NsrpqyqhaphtptivADQNLSPLFERISQLEKQLERQSVMIIDLERENNSLRYQINESEKRLN 252
                 2455777778888888899999999*********************************999875 PP

>> DUF16  Protein of unknown function DUF16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1   5.3e-05      0.14      40      89 ..     206     255 ..     191     262 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.3e-05
                 HHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......HHHHHH CS
       DUF16  40 eakvdklgeqinkleqkvekqgekikelkveqkaqgeelnkvdetlelil 89 
                 +++++ l+e+i++le++ e+q   i +l+ e +  + ++n+ ++ l++ +
  EFC38506.1 206 DQNLSPLFERISQLEKQLERQSVMIIDLERENNSLRYQINESEKRLNSAV 255
                 56777899********************************9999998755 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   2.3    0.0002      0.51       1      36 [.     215     250 ..     215     256 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0002
   FlaC_arch   1 ridelEnklsklsteletvkkeneelsksveelken 36 
                 ri +lE++l++ s+++  +++en++l+ +++e +++
  EFC38506.1 215 RISQLEKQLERQSVMIIDLERENNSLRYQINESEKR 250
                 899**************************9986665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1289  (0.0718947); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 2907.17
//
Query:       EFC38507.1  [L=665]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.6e-58  196.2  14.6    1.2e-57  195.7  14.6    1.1  1  ABC_membrane  ABC transporter transmembrane region
      6e-35  120.7   0.0    1.3e-34  119.6   0.0    1.6  1  ABC_tran      ABC transporter
    1.2e-06   28.2   0.1    0.00075   19.0   0.0    2.4  2  SMC_N         RecF/RecN/SMC N terminal domain
    0.00074   19.2   0.0     0.0017   18.1   0.0    1.5  1  AAA_29        P-loop containing region of AAA domain
    0.00077   19.7   0.0     0.0021   18.3   0.0    1.7  1  AAA_22        AAA domain
     0.0019   18.6   0.2      0.012   16.0   0.5    2.2  2  AAA_16        AAA ATPase domain
     0.0021   17.8   3.8      0.011   15.5   0.0    2.1  2  AAA_15        AAA ATPase domain
     0.0027   17.5   0.0      0.016   15.0   0.0    2.2  1  AAA_30        AAA domain
  ------ inclusion threshold ------
      0.012   16.4   4.7      0.025   15.5   4.7    1.4  1  DUF1764       Eukaryotic protein of unknown function (DUF1764
      0.016   15.1   0.0      0.044   13.7   0.0    1.7  1  RsgA_GTPase   RsgA GTPase
      0.069   13.2   0.0       0.25   11.3   0.0    1.9  2  AAA_5         AAA domain (dynein-related subfamily)
       0.11   11.3   0.1       0.29    9.9   0.0    1.7  2  ABC_ATPase    Predicted ATPase of the ABC class
       0.12   12.6   2.7        1.5    9.1   0.5    2.7  2  DUF3382       Domain of unknown function (DUF3382)
       0.14   12.4   0.3       0.84    9.9   0.3    2.2  1  SbcCD_C       Putative exonuclease SbcCD, C subunit
       0.91    9.3   5.5        1.2    8.9   0.1    2.8  3  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
        1.1    9.8   0.0        1.1    9.8   0.0    2.3  2  AAA_23        AAA domain


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  195.7  14.6   1.1e-60   1.2e-57       2     271 ..      82     357 ..      81     360 .. 0.96

  Alignments for each domain:
  == domain 1  score: 195.7 bits;  conditional E-value: 1.1e-60
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHH........HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHH CS
  ABC_membrane   2 iliillailagvlsplfplvlgrildtlldkgdpet........ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpms 90 
                   +l+ + a+ +gv+ + f +v+g ++++++++  + +        +++ vy+ +++++++a +i++++++++ln+++er+ +++r+ +f+++  q+m+
    EFC38507.1  82 FLGSIGAMGTGVIPISFQFVMGDLINVFSPTRADGStvtpeqqkAEIGVYASYFAIIAAAACIANFMSQFFLNWASERIGVAIRSAYFDSLTVQEMG 178
                   677788999**********************555555889********************************************************* PP

                   HHHHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane  91 ffdtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEsl 187
                   ffd ++vG l+  l++d+ +++++++ k+ +++q+l++f++g+i+++++gw+++lv+++++pl+il  ++++ i++kl+   +ka++ + s+a+E++
    EFC38507.1 179 FFDIKKVGALTITLSEDITRIQEIYSVKMATLLQNLAQFLIGVILALTSGWQMALVMMSTTPLMILGVVFLGGIIRKLTLAINKANDHSASIATEVM 275
                   ************************************************************************************************* PP

                   HTHHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHH CS
  ABC_membrane 188 sgirtVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailf 271
                    ++rtV+++++ee+++ +++k l++++ agi ka+a+g ++gi+  +    +ala+w+G+ lv +g++++g+  +++++  +lf
    EFC38507.1 276 GAMRTVRSMAGEEKERVRYKKDLTKMYLAGIGKAVAQGSTFGILVGILWGTTALAFWYGGGLVVEGTMNIGS--MLKVFGLTLF 357
                   ************************************************************************..8888776666 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  119.6   0.0   1.2e-37   1.3e-34       1     137 []     425     576 ..     425     576 .. 0.89

  Alignments for each domain:
  == domain 1  score: 119.6 bits;  conditional E-value: 1.2e-37
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH..................HH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren..................es 81 
                 lk+ sl++k+g+ va+vG++G+GKSt++ ll + ++p++G++ ldg d+ e++  +l+k+ig+++qep lf ++ +++n                  ++
  EFC38507.1 425 LKEFSLDIKAGQAVALVGPSGSGKSTIVGLLERFYDPAKGKVYLDGVDIAEIDPMWLHKNIGIVTQEPVLFATS-IYKNiayaigeenttmekvieaAK 522
                 7899*********************************************************************9.99999*****66666655555555 PP

                 HTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  82 deeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                 +++++ ++  l +    +t +++++ sLSgGqkqrv++arall++pkllllDE+t+
  EFC38507.1 523 SANCHSFIMDLPDG--YNTLLGERGVSLSGGQKQRVCIARALLQDPKLLLLDEATS 576
                 55555555555555..599999999*****************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0038       4.2      25      41 ..     436     452 ..     423     458 .. 0.82
   2 !   19.0   0.0   6.7e-07   0.00075     110     210 ..     504     617 ..     463     625 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0038
                 SEEEEEESTTSSHHHHH CS
                 xxxxxxxxxxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnll 41 
                 +  a+vGp GSGKs ++
  EFC38507.1 436 QAVALVGPSGSGKSTIV 452
                 45789*********997 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 6.7e-07
                 EEEETTEEE-HHHHHHHHHCTT-STT.................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx.................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 110 eykingkevtkkevsellesagiske.................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQ 191
                  y+i +++ t ++v e  +sa+ ++                  +LSgG+k+ v +a        +   l llDe  +aLD +  + v   l+   k   
  EFC38507.1 504 AYAIGEENTTMEKVIEAAKSANCHSFimdlpdgyntllgergvSLSGGQKQRVCIAR----ALLQDPKLLLLDEATSALDTESEALVQAALDLLMKGRT 598
                 46666666666666666666666555777888888888888889******9777654....345666799***************************** PP

                 EEEE-SSHHHCCC-SCEEE CS
                 xxxxxxxxxxxxxxxxxxx RF
       SMC_N 192 fivislreemlekadklvg 210
                  i+i++r  +++++dk++ 
  EFC38507.1 599 TICIAHRLSTVRNSDKICV 617
                 **************99875 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   1.5e-06    0.0017      17      39 ..     430     452 ..     422     463 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.5e-06
      AAA_29  17 ieidlkgatlltGpsGsGKSTll 39 
                 ++i+  +a+ l+GpsGsGKST++
  EFC38507.1 430 LDIKAGQAVALVGPSGSGKSTIV 452
                 567644499************98 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   1.9e-06    0.0021       5     109 ..     435     586 ..     431     604 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 1.9e-06
      AAA_22   5 agilvvtGesGtGKTtllrrlleqldeeakaee.................erpevvfvtlpsstsskdllrellralglelka................ 70 
                  + ++++G+sG+GK+t +  l + +d ++                     ++   +  + p++   ++++++++ a+g+e+ +                
  EFC38507.1 435 GQAVALVGPSGSGKSTIVGLLERFYDPAK---GkvyldgvdiaeidpmwlHKNIGIVTQEPVLF-ATSIYKNIAYAIGEENTTmekvieaaksanchsf 529
                 57889*******************98554...14569************988888999999999.999**********999999999999999999999 PP

      AAA_22  71 ...........erlsseell.ealeqalrarav...ielliiDEaqh.lr..seeal 109
                             + +   l   + ++ + ara    ++ll++DEa   l+  se+++
  EFC38507.1 530 imdlpdgyntlLGERGVSLSgGQKQRVCIARALlqdPKLLLLDEATSaLDteSEALV 586
                 99999999998666666666688888888888899999*******998876444444 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       7.5   8.4e+03      75     120 ..     247     293 ..     228     298 .. 0.64
   2 !   16.0   0.5     1e-05     0.012      24      52 ..     435     463 ..     424     602 .. 0.67

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 7.5
      AAA_16  75 alareellrqlldeaesaeleawrekleeala....avpelagaeasrll 120
                 ++   +++r+l  +   ++++++++ + +++      v+++ag+e++r++
  EFC38507.1 247 VFLG-GIIRKLTLA--INKANDHSASIATEVMgamrTVRSMAGEEKERVR 293
                 4534.666777666..3345555555555555566688888888887765 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 1e-05
      AAA_16  24 pelvllsGesGvGKsslvrellralekdg 52 
                 +++v l+G+sG+GKs++v  l r +  ++
  EFC38507.1 435 GQAVALVGPSGSGKSTIVGLLERFYDPAK 463
                 3789**************88776555552 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   2.6       0.2   2.2e+02     108     168 ..      14      69 ..       2      81 .. 0.49
   2 !   15.5   0.0   9.8e-06     0.011      14      75 ..     425     483 ..     424     535 .. 0.73

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.2
      AAA_15 108 lkkkesdlkktikdkklklkknelsdekisvekkkskkelpkekeeklekekeelkid.ked 168
                 +k  ++++k+ +k+ +++ k+ +  + k+      +  e +k +ee  ++++++l ++  ++
  EFC38507.1  14 VKAQQQEIKEDKKQPQTERKSRNPFKRKK------KQEEEKKDSEEIPDEREPNLTFKdGFT 69 
                 45555566666666666644222222222......222233334444444444444443444 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 9.8e-06
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnkekknkkvikiekedleifenisesk 75 
                 lk++++d++      l+G+ +sGKS+i+ +l+ F +      k +++++  d+ + +     k
  EFC38507.1 425 LKEFSLDIKAGqAVALVGPSGSGKSTIVGLLERFYDPA----KGKVYLDGVDIAEIDPMWLHK 483
                 68899999988899*********************988....566666666666555544444 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   1.4e-05     0.016      19     112 ..     436     589 ..     430     598 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.4e-05
      AAA_30  19 rvavltGpAGtGKttalkalreaweaa.g..........................grviglApt..gkaAkvLaeelgieastiakllkrlk....... 81 
                 + ++l+Gp G+GK+t+++ l++ ++ a g                          +  +++A +  ++ A +++ee      t++k++++ k       
  EFC38507.1 436 QAVALVGPSGSGKSTIVGLLERFYDPAkGkvyldgvdiaeidpmwlhknigivtqE-PVLFATSiyKNIAYAIGEE----NTTMEKVIEAAKsanchsf 529
                 47899********************9945777777777777777777777776642.2222222113344444433....3333333333333334444 PP

      AAA_30  82 .............................grarlepgtllivDEagmvdtkqlaallkaa 112
                                              +ra l++ +ll+ DEa  +  ++ +al++aa
  EFC38507.1 530 imdlpdgyntllgergvslsggqkqrvciARALLQDPKLLLLDEATSALDTESEALVQAA 589
                 444558888888888888888888888887677778888899998888777778887776 PP

>> DUF1764  Eukaryotic protein of unknown function (DUF1764)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.5   4.7   2.3e-05     0.025      14      75 ..      14      72 ..       2      76 .. 0.52

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 2.3e-05
     DUF1764 14 ifseskkkkkekekeeeeeekekkkkskkkkkkkkkkeeekkfedseskkrrktedGlpvYt 75
                + +++++ k++k++ +  +e++ ++  k+kkk++++k++++++ d++ +++ + +dG+++Y+
  EFC38507.1 14 VKAQQQEIKEDKKQPQ--TERKSRNPFKRKKKQEEEKKDSEEIPDER-EPNLTFKDGFTIYK 72
                2222222222222222..23333334444444444444455555555.8999*********8 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   3.9e-05     0.044      78     120 ..     413     456 ..     393     467 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.9e-05
                  EEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  78 evllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinall 120
                  ++++ s  + + l+e +  +k  + ++lvG+SG GKSt++  l 
   EFC38507.1 413 DFIYPSRPNVTVLKEFSLDIKAgQAVALVGPSGSGKSTIVGLLE 456
                  5555555666666777777776699**************98875 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00022      0.25       2      23 ..     438     459 ..     437     469 .. 0.83
   2 ?   -2.4   0.0         4   4.5e+03      40      77 ..     539     577 ..     513     601 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00022
                 EEEE--SSSSHHHHHHHGGGGB CS
       AAA_5   2 vlLvGppGtgKselaerlaaal 23 
                 v LvGp+G+gKs+++  l +++
  EFC38507.1 438 VALVGPSGSGKSTIVGLLERFY 459
                 67***************99987 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 4
                 HHH--B--.........--------.G-SEEEEESGGG- CS
       AAA_5  40 dlkgrreikngttslvdsplvraar.egeilvlDEvera 77 
                 +l+g+r ++ ++ + +  ++ ra    +++l+lDE + a
  EFC38507.1 539 TLLGERGVSLSGGQKQRVCIARALLqDPKLLLLDEATSA 577
                 566666666333333344444444337888888887765 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.4   2.7e+03     242     265 ..     432     456 ..     430     460 .. 0.80
   2 ?    9.9   0.0   0.00026      0.29     299     352 ..     523     577 ..     515     601 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.4
                 E-SS.EEEEEE-TTSSHHHHHHHHH CS
  ABC_ATPase 242 ipkG.vtlIvGggfhGKsTLLeAle 265
                 i+ G  +++vG+   GKsT++  le
  EFC38507.1 432 IKAGqAVALVGPSGSGKSTIVGLLE 456
                 7777777899*********987665 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00026
                 EE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS- CS
  ABC_ATPase 299 gvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsA 352
                 +++  +Fi +LP g +t         SG   q + i++al  + kllL+DE tsA
  EFC38507.1 523 SANCHSFIMDLPDGYNTLlGERGVSLSGGQKQRVCIARALLQDPKLLLLDEATSA 577
                 678899***********955566678****************************9 PP

>> DUF3382  Domain of unknown function (DUF3382)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1      0.16   1.8e+02      41      63 ..     139     161 ..     122     180 .. 0.81
   2 ?    9.1   0.5    0.0014       1.5       4      80 ..     206     279 ..     203     300 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.16
     DUF3382  41 vaiavavvfvgqLlrplllqalk 63 
                  a+a+++ f+ q+++++ +++++
  EFC38507.1 139 AAAACIANFMSQFFLNWASERIG 161
                 47889999*******99988776 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0014
     DUF3382   4 knAliaallalvlfvpilGlqleldgtrlvleprwglvaiavavvfvgqLlrplllqalkarkklkkveskadgvlv 80 
                 k A++   la  l+++il+l   ++g ++ l    ++ +++ +vvf+g ++r+l+l   ka+ ++++++++++g+  
  EFC38507.1 206 KMATLLQNLAQFLIGVILAL---TSGWQMALVMMSTTPLMILGVVFLGGIIRKLTLAINKANDHSASIATEVMGAMR 279
                 55555566777788888888...6666666666668999999***********************999999988765 PP

>> SbcCD_C  Putative exonuclease SbcCD, C subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.3   0.00075      0.84      28      83 ..     543     585 ..     520     592 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00075
     SbcCD_C  28 rssgtlSGGekqflaylalaaalaalyssaegrepalrlvfLDEAFsklDeesiat 83 
                 ++  +lSGG+kq    +++a   +al+++       ++l++LDEA s lD es a 
  EFC38507.1 543 ERGVSLSGGQKQ---RVCIA---RALLQD-------PKLLLLDEATSALDTESEAL 585
                 555667777773...45666...344444.......89************998665 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   1.3      0.55   6.2e+02      80     133 ..      16      72 ..       9      77 .. 0.80
   2 ?    8.9   0.1    0.0011       1.2       3      22 ..     439     458 ..     438     478 .. 0.85
   3 ?   -0.4   0.0       0.7   7.9e+02     236     271 ..     547     579 ..     508     597 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.55
      AAA_21  80 rsqv...eeklssvetllesgllldkrsleeedvfnpeargirggvsvfslkelsvs 133
                  +q    e+k++ + +++++ ++++k+  eee++++ e  ++r+    f++ + +++
  EFC38507.1  16 AQQQeikEDKKQPQTERKSRNPFKRKKKQEEEKKDSEEIPDEREPNLTFKDGFTIYK 72 
                 344445999999999999999**********99999999999998888887776665 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0011
      AAA_21   3 vliGpNgsGKSnLLdaldll 22 
                 +l+Gp gsGKS++  +l+ +
  EFC38507.1 439 ALVGPSGSGKSTIVGLLERF 458
                 79***********9998776 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.7
      AAA_21 236 elSdGtkrllalltallralkkgsllliDEpEngLH 271
                 +lS G+k+  +++ all+++   +lll+DE  + L+
  EFC38507.1 547 SLSGGQKQRVCIARALLQDP---KLLLLDEATSALD 579
                 46999999989999999999...99*****777666 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   7.6       9.2     1e+04     150     187 ..      16      53 ..       3      62 .. 0.46
   2 ?    9.8   0.0   0.00094       1.1      20      36 ..     436     452 ..     411     456 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 9.2
      AAA_23 150 dkkerleelekeleeledekkllekleqekekekelee 187
                 +++++++e +k+ +++ + ++ ++++++++e++k  ee
  EFC38507.1  16 AQQQEIKEDKKQPQTERKSRNPFKRKKKQEEEKKDSEE 53 
                 33333333333333333333333333333344443333 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00094
      AAA_23  20 gltlItGpNGaGKTTil 36 
                   ++++Gp G+GK+Ti+
  EFC38507.1 436 QAVALVGPSGSGKSTIV 452
                 46789***********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1896  (0.10575); expected 358.6 (0.02)
Passed bias filter:                     1093  (0.0609627); expected 358.6 (0.02)
Passed Vit filter:                       143  (0.0079759); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.91u 0.34s 00:00:01.25 Elapsed: 00:00:00.49
# Mc/sec: 4058.22
//
Query:       EFC38508.1  [L=361]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0051   16.6   0.0      0.025   14.4   0.0    2.1  2  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0   1.4e-06     0.025       4      30 .]     203     229 ..     200     229 .. 0.88
   2 ?   -1.5   0.0      0.14   2.5e+03      14      24 ..     267     277 ..     266     278 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.4e-06
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 v  G+yH +  t +++++c+G ++  Q
  EFC38508.1 203 VKGGYYHVILRTKENKIFCCGYDNMHQ 229
                 677******************999766 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.14
      RCC1_2  14 LtedGeVlcWG 24 
                 L + ++V+c G
  EFC38508.1 267 LNSKNDVFCIG 277
                 77899****87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (361 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.25s 00:00:00.72 Elapsed: 00:00:00.41
# Mc/sec: 2620.77
//
Query:       EFC38509.1  [L=512]
Description: TPR domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.6e-17   61.5  11.7      5e-06   26.2   0.0    5.4  5  TPR_2           Tetratricopeptide repeat
    5.3e-16   57.7  11.2    3.2e-07   29.9   0.1    5.3  5  TPR_1           Tetratricopeptide repeat
    2.2e-13   50.3   3.7    3.3e-06   27.3   0.3    2.7  2  TPR_12          Tetratricopeptide repeat
    3.7e-07   29.8  13.1     0.0039   17.3   0.1    5.9  7  TPR_8           Tetratricopeptide repeat
    1.5e-05   25.6   0.1       0.39   11.4   0.0    3.2  3  TPR_16          Tetratricopeptide repeat
    0.00039   20.9   2.2        2.5    8.9   0.0    4.3  4  TPR_6           Tetratricopeptide repeat
     0.0045   17.5   0.1       0.12   12.9   0.0    2.6  2  TPR_19          Tetratricopeptide repeat
     0.0046   16.9   3.8        1.4    9.1   0.1    3.8  3  TPR_7           Tetratricopeptide repeat
     0.0069   16.6   4.0        0.4   10.9   0.2    2.6  2  ANAPC3          Anaphase-promoting complex, cyclosome, subuni
     0.0094   16.1   0.1      0.099   12.8   0.0    2.5  3  TPR_9           Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.048   13.5   3.2       0.14   12.0   0.4    2.6  2  Chordopox_A30L  Chordopoxvirus A30L protein
      0.073   13.0   0.0       0.16   11.9   0.0    1.5  1  F-box           F-box domain


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0     0.006       8.9       3      30 ..      91     118 ..      89     120 .. 0.85
   2 !   19.9   0.5   3.5e-07   0.00053       5      29 ..     134     158 ..     131     160 .. 0.93
   3 ?   -1.5   0.0       2.6   3.9e+03      18      30 ..     218     230 ..     215     231 .. 0.80
   4 !   12.1   0.4   0.00011      0.17       3      30 ..     250     277 ..     248     281 .. 0.92
   5 !   26.2   0.0   3.4e-09     5e-06       4      32 ..     290     318 ..     288     320 .. 0.95

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.006
       TPR_2   3 alynlGlayyklgdyeeAleafekAlel 30 
                 +l ++  a ++ +d++ A+e++ +Al+l
  EFC38509.1  91 LLVQRCVARLEGNDFDLAKEDLHEALSL 118
                 5677888889999*************98 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 3.5e-07
       TPR_2   5 ynlGlayyklgdyeeAleafekAle 29 
                 y lG ++y +g+y+eA+++f+k++ 
  EFC38509.1 134 YLLGICCYGNGEYKEAANYFQKSID 158
                 89********************986 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 2.6
       TPR_2  18 eeAleafekAlel 30 
                 ++A+++++ +l l
  EFC38509.1 218 NQAKNYYNHSLML 230
                 5799999988865 PP

  == domain 4  score: 12.1 bits;  conditional E-value: 0.00011
       TPR_2   3 alynlGlayyklgdyeeAleafekAlel 30 
                 ++ + G ayy    y +A+ +f++A+el
  EFC38509.1 250 LYIRAGVAYYSGTYYLDAIPYFNQAIEL 277
                 68999**********************9 PP

  == domain 5  score: 26.2 bits;  conditional E-value: 3.4e-09
       TPR_2   4 lynlGlayyklgdyeeAleafekAleldP 32 
                 +yn+Gl+yy+lg+++ A+++f k+++l P
  EFC38509.1 290 YYNRGLCYYYLGELQLAINDFTKSISLMP 318
                 9**************************99 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.0      0.01        15       6      30 ..      94     118 ..      89     118 .. 0.82
   2 !   18.2   1.3     1e-06    0.0016       5      29 ..     134     158 ..     131     160 .. 0.93
   3 !    6.7   0.1    0.0045       6.7      19      30 ..     266     277 ..     264     281 .. 0.85
   4 !   29.9   0.1   2.1e-10   3.2e-07       3      31 ..     289     317 ..     288     318 .. 0.94
   5 ?   -3.6   0.0       8.1   1.2e+04       4      15 ..     327     338 ..     326     338 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.01
                 HHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyyekALel 30 
                 ++ +a ++ +++d A e+  +AL+l
  EFC38509.1  94 QRCVARLEGNDFDLAKEDLHEALSL 118
                 5666777779*************87 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 1e-06
                 HHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekALe 29 
                 y lG +++ +g+y+eA  y++k + 
  EFC38509.1 134 YLLGICCYGNGEYKEAANYFQKSID 158
                 89********************997 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0045
                 HHHHHHHHHHHH CS
       TPR_1  19 eAleyyekALel 30 
                 +A+ y+++A+el
  EFC38509.1 266 DAIPYFNQAIEL 277
                 7**********9 PP

  == domain 4  score: 29.9 bits;  conditional E-value: 2.1e-10
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALeln 31 
                 ++yn+G++y++lg+++ A+ ++ k ++l 
  EFC38509.1 289 SYYNRGLCYYYLGELQLAINDFTKSISLM 317
                 6*************************985 PP

  == domain 5  score: -3.6 bits;  conditional E-value: 8.1
                 HHHHHHHHHHTT CS
       TPR_1   4 lynlGnayfklg 15 
                 +  +++ y +lg
  EFC38509.1 327 YTMRAVSYGRLG 338
                 777888888876 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.1   3.7e-08   5.6e-05       3      75 ..      89     160 ..      87     162 .. 0.85
   2 !   27.3   0.3   2.2e-09   3.3e-06       8      74 ..     252     316 ..     246     318 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 3.7e-08
      TPR_12   3 atalnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaia 75 
                 at+l+++ ++ ++  ++d A e l++al +++ + ++d+  +    + Lg++++  g+y+eA ++++++++ +
  EFC38509.1  89 ATLLVQRCVARLEGNDFDLAKEDLHEALSLMNVVNNGDSKFY-LLEYLLGICCYGNGEYKEAANYFQKSIDHR 160
                 5666666667777778******************99999555.68899*********************9976 PP

  == domain 2  score: 27.3 bits;  conditional E-value: 2.2e-09
      TPR_12   8 nlaavlrrlgr.ydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                  +a v ++ g  y +A+ ++++a+e+ ++++   ++++ ++++n g +y++lg+++ A++ +++++ +
  EFC38509.1 252 IRAGVAYYSGTyYLDAIPYFNQAIELGESYH---SEYVESSYYNRGLCYYYLGELQLAINDFTKSISL 316
                 46777777777799*************9995...45699*************************9876 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0         7     1e+04      21      31 ..      29      39 ..      26      40 .. 0.69
   2 ?    1.0   0.0      0.43   6.5e+02      15      30 ..     103     118 ..      98     118 .. 0.89
   3 !    7.7   0.4     0.003       4.5       5      28 ..     134     157 ..     134     158 .. 0.91
   4 ?   -0.2   0.0         1   1.5e+03      18      29 ..     218     229 ..     217     230 .. 0.82
   5 !    6.7   0.2    0.0063       9.4       4      30 ..     251     277 ..     249     280 .. 0.92
   6 !   17.3   0.1   2.6e-06    0.0039       3      30 ..     289     316 ..     287     318 .. 0.94
   7 ?   -2.1   0.0       4.3   6.5e+03       6      16 ..     329     339 ..     326     351 .. 0.53

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 7
                HHHHHHHHHHH CS
       TPR_8 21 keyyekaleld 31
                ++++ +a++++
  EFC38509.1 29 IKAMDEAIKAN 39
                67777777765 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.43
                 T-HHHHHHHHHHHHHH CS
       TPR_8  15 gdyeeAkeyyekalel 30 
                 +d++ Ake + +al+l
  EFC38509.1 103 NDFDLAKEDLHEALSL 118
                 799*******999987 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.003
                 HHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekal 28 
                 y+lg ++   g+y+eA  y++k +
  EFC38509.1 134 YLLGICCYGNGEYKEAANYFQKSI 157
                 789999999*************98 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 1
                 HHHHHHHHHHHH CS
       TPR_8  18 eeAkeyyekale 29 
                 ++Ak yy++ l 
  EFC38509.1 218 NQAKNYYNHSLM 229
                 68*****99875 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.0063
                 HHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekalel 30 
                 y + g +y +   y  A+ y+++a+el
  EFC38509.1 251 YIRAGVAYYSGTYYLDAIPYFNQAIEL 277
                 8889999999999************98 PP

  == domain 6  score: 17.3 bits;  conditional E-value: 2.6e-06
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekalel 30 
                 +yyn g++y  lg+++ A+  + k ++l
  EFC38509.1 289 SYYNRGLCYYYLGELQLAINDFTKSISL 316
                 8*************************98 PP

  == domain 7  score: -2.1 bits;  conditional E-value: 4.3
                 HHHHHHHHTT- CS
       TPR_8   6 nlgsiylklgd 16 
                 + +  y  lg 
  EFC38509.1 329 MRAVSYGRLGL 339
                 55555555553 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       1.5   2.3e+03       7      24 ..      99     116 ..      98     119 .. 0.86
   2 !    9.7   0.0   0.00088       1.3      38      63 ..     134     159 ..     123     162 .. 0.90
   3 !   11.4   0.0   0.00026      0.39       5      56 ..     255     310 ..     253     314 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.5
      TPR_16   7 alragdyddAaaaleaal 24 
                 +l+ +d+d A + l++al
  EFC38509.1  99 RLEGNDFDLAKEDLHEAL 116
                 67889*********9998 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00088
      TPR_16  38 lllgdaalrqgrlaeAaalyraalra 63 
                 +llg +++ +g+++eAa ++++ +++
  EFC38509.1 134 YLLGICCYGNGEYKEAANYFQKSIDH 159
                 89***************999987765 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 0.00026
      TPR_16   5 raalragd.yddAaaaleaalkrdpssPd...aaeAllllgdaalrqgrlaeAa.al 56 
                   a+++g  y dA++++++a++++ +s        +++++g++++ +g+l++A+ ++
  EFC38509.1 255 GVAYYSGTyYLDAIPYFNQAIELG-ESYHseyVESSYYNRGLCYYYLGELQLAInDF 310
                 556666666899**********99.44447888889*****************9776 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       4.4   6.5e+03       9      25 ..      98     114 ..      97     117 .. 0.77
   2 !    7.7   0.0    0.0041       6.1       4      25 ..     134     155 ..     131     159 .. 0.90
   3 ?   -0.4   0.1       1.5   2.3e+03       5      28 ..     253     276 ..     250     277 .. 0.80
   4 !    8.9   0.0    0.0016       2.5       2      25 ..     289     312 ..     288     316 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 4.4
                 HHHHHHHHHHHHHHHHH CS
       TPR_6   9 syrklgdtdkAlealer 25 
                 ++++++d d A+e l +
  EFC38509.1  98 ARLEGNDFDLAKEDLHE 114
                 567889*****998765 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0041
                 HHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   4 yklalsyrklgdtdkAlealer 25 
                 y+l+ + +  g++ +A  ++++
  EFC38509.1 134 YLLGICCYGNGEYKEAANYFQK 155
                 99******988**********8 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 1.5
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealerlik 28 
                 +++ +y++++ + +A+ ++++ i+
  EFC38509.1 253 RAGVAYYSGTYYLDAIPYFNQAIE 276
                 678999998888899999998886 PP

  == domain 4  score: 8.9 bits;  conditional E-value: 0.0016
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealer 25 
                 ++y+++l+y+ lg+ + A+  + +
  EFC38509.1 289 SYYNRGLCYYYLGELQLAINDFTK 312
                 68*********99***99987765 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.0   7.9e-05      0.12       2      48 ..     107     153 ..     100     159 .. 0.87
   2 ?    1.5   0.0      0.28   4.2e+02      10      45 ..     267     314 ..     264     323 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 7.9e-05
      TPR_19   2 laegdyaeAlalleqalqedpknaearllLAeallalgqldeAealL 48 
                 la +d+ eAl+l+  +   d k   + +lL ++++ +g+++eA +  
  EFC38509.1 107 LAKEDLHEALSLMNVVNNGDSKFYLLEYLLGICCYGNGEYKEAANYF 153
                 6778888999999998888999*********************8765 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.28
      TPR_19  10 Alalleqalqe............dpknaearllLAeallalgqldeAe 45 
                 A++++ qa++             + + +   ++L e++la +++++ +
  EFC38509.1 267 AIPYFNQAIELgesyhseyvessYYNRGLCYYYLGELQLAINDFTKSI 314
                 666666665444444333343334445555668899999999988765 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.1   0.00096       1.4       5      26 ..     136     157 ..     132     173 .. 0.80
   2 ?    0.9   0.1      0.39   5.8e+02       6      28 ..     255     277 ..     250     284 .. 0.74
   3 ?    5.3   0.1     0.016        24       1      21 [.     296     316 ..     289     320 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00096
       TPR_7   5 LarlysrlGdyeeAielyeqsL 26 
                 L+ ++   G+y+eA+ ++++s+
  EFC38509.1 136 LGICCYGNGEYKEAANYFQKSI 157
                 77777779************43 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.39
       TPR_7   6 arlysrlGdyeeAielyeqsLal 28 
                 +++y +  +y +Ai ++ q+++l
  EFC38509.1 255 GVAYYSGTYYLDAIPYFNQAIEL 277
                 677777777889*******6655 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.016
       TPR_7   1 aLlnLarlysrlGdyeeAiel 21 
                 ++++L++l+ + +d+ + i+l
  EFC38509.1 296 CYYYLGELQLAINDFTKSISL 316
                 566666666666666666654 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.9   0.2   0.00027       0.4      38      81 ..     111     155 ..     107     161 .. 0.67
   2 !    6.1   0.5    0.0088        13       6      49 ..     272     313 ..     262     323 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00027
                 -HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3  38 qykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaLek 81 
                 + ++A+ l +   + +sk     yl++ c++  ++y+eA + ++k
  EFC38509.1 111 DLHEALSLMNVVnNGDSKFYLLEYLLGICCYGNGEYKEAANYFQK 155
                 566777777777444444446677888888888888888777765 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0088
                 HHHHHHHHHHH.HHH--HHHHHHH.HHHHHHTT-HHHHHHHHHCT CS
      ANAPC3   6 knAiflaerllaaetespedayll.AlclylngqykrAyellrka 49 
                 + Ai l+e ++   +e  e++y+  +lc+y +g+ + A++ + k+
  EFC38509.1 272 NQAIELGESYH---SEYVESSYYNrGLCYYYLGELQLAINDFTKS 313
                 56777777777...66666666655**********9999877665 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       4.3   6.4e+03      34      57 ..      94     117 ..      89     119 .. 0.76
   2 ?   -0.9   0.0       1.3   1.9e+03      36      58 ..     137     159 ..     134     165 .. 0.86
   3 !   12.8   0.0   6.7e-05     0.099      32      70 ..     290     331 ..     288     332 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 4.3
       TPR_9  34 dRGlllaqlGclsaAladLeayla 57 
                  R +++ + +++  A +dL  +l+
  EFC38509.1  94 QRCVARLEGNDFDLAKEDLHEALS 117
                 667778888899999999988775 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.3
       TPR_9  36 GlllaqlGclsaAladLeaylal 58 
                 G++ +  G +++A++ ++  +++
  EFC38509.1 137 GICCYGNGEYKEAANYFQKSIDH 159
                 7788889**********988876 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 6.7e-05
       TPR_9  32 rrdRGlllaqlGclsaAladLeaylalap...dapdaeaira 70 
                 ++ RGl+++ lG l+ A++d+   ++l p   +++ ++++ra
  EFC38509.1 290 YYNRGLCYYYLGELQLAINDFTKSISLMPllkQRDIVYTMRA 331
                 689********************9999998888888877776 PP

>> Chordopox_A30L  Chordopoxvirus A30L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.4   9.3e-05      0.14      23      67 ..      23      66 ..      17      69 .. 0.87
   2 ?    0.6   0.1      0.34   5.1e+02       4      19 ..     368     383 ..     367     385 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 9.3e-05
  Chordopox_A30L 23 sefaatlsvikElisqINlkvleinKKsKKnsraieslnyvskRE 67
                    +e+++ + ++ E i++ Nlk++++ K+ K  + +   +n+v+kR 
      EFC38509.1 23 QEIGSGIKAMDEAIKANNLKMFDLFKRKKQQIDQAA-SNQVEKRS 66
                    588999*******************99888887776.99999995 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.34
  Chordopox_A30L   4 inEsnflHLLsnLsnn 19 
                     +nE+ ++H++s L ++
      EFC38509.1 368 LNEDALSHIMSFLQTK 383
                     7*********999875 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00011      0.16       2      38 ..     364     400 ..     363     402 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
                 HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHT CS
       F-box   2 tlsrLPsevlrhILerLplsdllalrrVSkgwrilid 38 
                 +l  L ++ l hI+++L ++ ll  ++  k  r +i+
  EFC38509.1 364 HLRLLNEDALSHIMSFLQTKQLLVVSSLNKYTRMFIK 400
                 5667999**********************99999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (512 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1215  (0.0677673); expected 358.6 (0.02)
Passed bias filter:                      563  (0.0314016); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.64u 0.27s 00:00:00.91 Elapsed: 00:00:00.45
# Mc/sec: 3424.81
//
Query:       EFC38510.1  [L=380]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0011   18.4   6.2     0.0018   17.7   6.2    1.3  1  FAM76     FAM76 protein
  ------ inclusion threshold ------
        2.5    8.3  11.4         33    4.7  11.3    2.5  1  Cnn_1N    Centrosomin N-terminal motif 1


Domain annotation for each model (and alignments):
>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   6.2   2.1e-07    0.0018     182     290 ..     151     260 ..     101     268 .. 0.68

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 2.1e-07
       FAM76 182 rss..rlevskleeeklaeekesnetskksldsnssdhlvavtqLkeeiaslkkqleqkdqellekdkkitelkae.llekekelreklkelekeakek 277
                 +++  ++++s   ++ l+++++ n++++++++++ s++   ++qL+e+i+ l+++le++ +++ e +++  elk+  + ++++el+++ + ++k+a++k
  EFC38510.1 151 QTKdfNSSTS-SPTNILSTNSPYNHHIQHEVHAADSQQ-HLINQLRERIHLLERELETQHKTITELQRENYELKTApNKRENSELQNQNEPRKKKAQKK 247
                 2221122222.223445566666666666665555444.3589******************************97625666778999999999999998 PP

       FAM76 278 ieklekkirellk 290
                  ++    +++l  
  EFC38510.1 248 RKTSPVSNEQLSN 260
                 8887777777765 PP

>> Cnn_1N  Centrosomin N-terminal motif 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7  11.3    0.0037        33      19      69 ..     193     247 ..     190     258 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0037
      Cnn_1N  19 LKLriyfLeerleklseeqkeellkenielkv.....eveslqkelkekkkllrea 69 
                 L+ ri+ Le +le  ++ +++el +en elk+     e+ +lq++++ +kk+ ++ 
  EFC38510.1 193 LRERIHLLERELETQHK-TITELQRENYELKTapnkrENSELQNQNEPRKKKAQKK 247
                 6669***********99.99*********987444447778888888888777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (380 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2191  (0.122204); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.44
# Mc/sec: 2599.32
//
Query:       EFC38511.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.012   15.8   6.2      0.017   15.2   6.2    1.3  1  UPF0242        Uncharacterised protein family (UPF0242) N-ter
      0.094   12.3   1.2       0.11   12.0   1.2    1.1  1  Exonuc_VII_L   Exonuclease VII, large subunit
       0.13   12.8   1.0       0.96   10.0   0.2    2.3  2  MFMR           G-box binding protein MFMR
       0.17   12.6   9.0         12    6.6   6.8    3.2  2  DUF573         Protein of unknown function, DUF573
       0.98    9.9   8.0       0.57   10.6   4.1    2.4  2  FlaC_arch      Flagella accessory protein C (FlaC)
        1.6    9.3  12.4       0.51   10.8   7.2    2.3  2  DUF16          Protein of unknown function DUF16
        1.8    8.7  15.8       0.19   11.9  11.2    1.7  2  Tropomyosin_1  Tropomyosin like


Domain annotation for each model (and alignments):
>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   6.2   6.7e-06     0.017      82     183 ..     113     212 ..      71     220 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 6.7e-06
     UPF0242  82 eglktkeealeelqeeeeeLkeeldakeeelerlkeenqqLqekleaiaedfeelkleleeqLaekqe..llqeyqetieeqrsvlekrqdqieqLesk 178
                 e  +t +  +e+l e+ ++L+  ++++++++  l++enq+++ek+ +     +e +++ +e+L+  ++  +  ++   i e  ++ +k ++q+++Le  
  EFC38511.1 113 EMGRTMDGLIEKLYERIQKLESDVKKQDSTISILENENQKMKEKKRK----HDEILKKRDETLDFTETkrKDRKLFLVIDEFEKSQQKANNQVKNLENY 207
                 4555666689********************************98887....788888889988755550045567789999999999999999999987 PP

     UPF0242 179 VrDln 183
                   D n
  EFC38511.1 208 TVDWN 212
                 66665 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   1.2   4.4e-05      0.11     152     261 ..     110     241 ..      68     251 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.4e-05
  Exonuc_VII_L 152 lerrlekaikrlleekkqrleklasrlkspeellerkrqrldeleerleralkkqlkkkrerleelkerlk........ekleekkerlkklkerle 240
                   +++++ + ++ l+e+  +r++kl+s++k++++ ++  +++ ++++e+ ++ +++ lkk+ e+l+ ++++ k        +++e+ +++ +++ ++le
    EFC38511.1 110 IRDEMGRTMDGLIEKLYERIQKLESDVKKQDSTISILENENQKMKEKKRK-HDEILKKRDETLDFTETKRKdrklflviDEFEKSQQKANNQVKNLE 205
                   56677778888888888999999999976666555555555555555554.5666777777777777444234555566444444444433333333 PP

  Exonuc_VII_L 241 ...............lleekkerleeleeklealsp 261
                                   +++k++ ++ +    ++ +p
    EFC38511.1 206 nytvdwngeqfvlidAFSNKSDIVNYYYPLYQSNNP 241
                   333455555555444455555555555555555555 PP

>> MFMR  G-box binding protein MFMR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.2   0.00037      0.96      14      62 ..      54     101 ..      44     108 .. 0.76
   2 ?    0.6   0.0      0.33   8.4e+02      14      38 ..     192     215 ..     185     242 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00037
        MFMR  14 kasspaksseqsavavvypdWsalqayygsgvlppgffasavasspaph 62 
                 k+ ++ +++ +s +  ++  W +   y+ ++ + +++f+s+v++sp+ h
  EFC38511.1  54 KPFESRDETCNS-TRKSTFTWGNSFEYWEKKQMSQPYFTSSVSTSPKGH 101
                 555555533333.4445889*9777899*****************9977 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.33
        MFMR  14 kasspaksseqsavavvypdWsalq 38 
                 k++++a +++ ++ + ++ dW + q
  EFC38511.1 192 KSQQKA-NNQVKNLENYTVDWNGEQ 215
                 333333.356677788889999766 PP

>> DUF573  Protein of unknown function, DUF573
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.043   1.1e+02       6      51 ..      32      84 ..      27      89 .. 0.75
   2 ?    6.6   6.8    0.0047        12      37      87 ..     134     184 ..      86     189 .. 0.72

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.043
      DUF573  6 seeDEielLqglldfksktgts.pksdldafyeavksslss......dvsksq 51
                 eeDE++ L ++ +f ++t  s p ++ d+ +++ ++s+ +       ++k+q
  EFC38511.1 32 GEEDEVAALPNFNEFLRDTFVSkPFESRDETCNSTRKSTFTwgnsfeYWEKKQ 84
                69*************99998853779999999999998866455554444455 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0047
      DUF573  37 eavksslssdvsk....sqlseKlrrLkkkyrnavskikkgkdpsfkkphdrklf 87 
                   vk++ s    +    ++  +K+++ k+k++++++k +++ d++ +k +drklf
  EFC38511.1 134 SDVKKQDS----TisilENENQKMKEKKRKHDEILKKRDETLDFTETKRKDRKLF 184
                 22222222....1233466789***************99**************99 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   4.1   0.00022      0.57       1      29 [.     128     156 ..     128     166 .. 0.90
   2 ?   -0.2   0.1      0.53   1.4e+03       3      34 ..     188     205 ..     182     209 .. 0.56

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00022
   FlaC_arch   1 ridelEnklsklsteletvkkeneelsks 29 
                 ri++lE++++k +++++ +++en++++++
  EFC38511.1 128 RIQKLESDVKKQDSTISILENENQKMKEK 156
                 89************************987 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.53
   FlaC_arch   3 delEnklsklsteletvkkeneelsksveelk 34 
                 de+              +k++++ +++v++l+
  EFC38511.1 188 DEF--------------EKSQQKANNQVKNLE 205
                 444..............444444444444443 PP

>> DUF16  Protein of unknown function DUF16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   7.2    0.0002      0.51      31      94 ..      93     173 ..      64     182 .. 0.70
   2 ?    0.9   2.1      0.25   6.4e+02      31      77 ..     168     215 ..     158     226 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0002
                 ..................BHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......HHHHHHHHHHH CS
       DUF16  31 s.................nkqrLkkieakvdklgeqinkleqkvekqgekikelkveqkaqgeelnkvdetleliletLqk 94 
                 s                  ++  + ++  ++kl e+i+kle  v+kq+  i+ l++e ++ +e+  k de l+   etL+ 
  EFC38511.1  93 SvstspkghdkipfhsaiRDEMGRTMDGLIEKLYERIQKLESDVKKQDSTISILENENQKMKEKKRKHDEILKKRDETLDF 173
                 355555555555554444444445566678899999**************9999999999999888888888777777654 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.25
                 .BHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHH.HHHHHHH. CS
       DUF16  31 snkqrLkkieakvdklgeqinkleqkvekqgekikelkv.eqkaqgee 77 
                 +   ++++ + k +kl+  i++ e+  +k ++++k+l++ +++  ge+
  EFC38511.1 168 DETLDFTETKRKDRKLFLVIDEFEKSQQKANNQVKNLENyTVDWNGEQ 215
                 344455555555557778888888888888888888865245555555 PP

>> Tropomyosin_1  Tropomyosin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9  11.2   7.5e-05      0.19      34     128 ..     119     212 ..     111     216 .. 0.81
   2 ?   -2.8   0.1       2.5   6.4e+03      98     117 ..     252     271 ..     245     272 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 7.5e-05
  Tropomyosin_1  34 eqeiksLtkknqqleeevekleeklkeakekae.esekkktnnealtrkiqlLE.eeleesdkkLkettekLretdvkaeelERkvkaLeqerdew 127
                    +  i++L +++q+le++v k +++++  +++++  +ekk+++ e l+++ + L   e  + d+kL   ++  ++++ ka+    +vk+Le+   +w
     EFC38511.1 119 DGLIEKLYERIQKLESDVKKQDSTISILENENQkMKEKKRKHDEILKKRDETLDfTETKRKDRKLFLVIDEFEKSQQKAN---NQVKNLENYTVDW 211
                    667999*******************98876655157788888999****9999856888899999888888877777776...5899999988888 PP

  Tropomyosin_1 128 e 128
                    +
     EFC38511.1 212 N 212
                    5 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.5
  Tropomyosin_1  98 ettekLretdvkaeelERkv 117
                    e  +kL  t+ +  e+ERk+
     EFC38511.1 252 EEYKKLFSTNPHVKESERKR 271
                    55667777777777788775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2223  (0.123989); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.58
# Mc/sec: 1519.28
//
Query:       EFC38512.1  [L=255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00038   19.9   3.8     0.0006   19.3   3.8    1.3  1  FAM76          FAM76 protein
     0.0028   18.1   4.2     0.0061   17.0   4.2    1.6  1  GPS2_interact  G-protein pathway suppressor 2-interacting dom
  ------ inclusion threshold ------
      0.056   13.5   3.7      0.057   13.5   0.8    2.4  2  V-set_2        ICOS V-set domain
       0.13   12.9   3.7       0.42   11.3   1.4    2.5  2  YabA           Initiation control protein YabA
        0.2   11.8   2.6        2.4    8.4   1.2    2.4  2  Baculo_LEF-10  Baculovirus late expression factor 10 (LEF-10)


Domain annotation for each model (and alignments):
>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   3.8   1.7e-07    0.0006     172     279 ..      48     153 ..       4     169 .. 0.67

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 1.7e-07
       FAM76 172 skkkskkhkkrssrlevskleeeklaeekesnetskksldsnssdhlvavtqLkeeiaslkkqleqkdqellekdkkitelkaellekekelreklkel 270
                 ++  + k + +++  +v + + e ++++++s +   +++d++ +d  ++v+ L ++i+++++++ ++ q++++  k+  +lk+ ++ k +  r+kl+++
  EFC38512.1  48 QEFCQVKFEGQQT-HQVDNPRFEAISQSSSSLSCDGQHVDLQ-NDSSIQVSSLIQKIEEMERRIYEQSQVISNLLKENQSLKTRKIGKPTACRKKLTNQ 144
                 1111222222222.2233333223444444444455588887.9******************************************************* PP

       FAM76 271 ekeakekie 279
                  k+++  +e
  EFC38512.1 145 SKQMTLVQE 153
                 999876554 PP

>> GPS2_interact  G-protein pathway suppressor 2-interacting domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   4.2   1.7e-06    0.0061       2      88 ..      65     152 ..      64     153 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.7e-06
  GPS2_interact   2 tpkvEaiSptlps.eaeqeqelvpsrls..KdeLlqnidkvDREiakveqqiskLkkkqkeleeeaa.kpkeeekpvepssseskhrsiaq 88 
                    +p+ EaiS  ++s  ++ ++  +++ +s     L+q+i+ + R i    q is+L k ++ l++++  kp+  +k+ +++   sk+  ++q
     EFC38512.1  65 NPRFEAISQSSSSlSCDGQHVDLQNDSSiqVSSLIQKIEEMERRIYEQSQVISNLLKENQSLKTRKIgKPTACRKKLTNQ---SKQMTLVQ 152
                    68899**99998877665554444444411568*****************************998764888888888888...77777776 PP

>> V-set_2  ICOS V-set domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.38   1.4e+03      54      66 ..      44      56 ..      27      80 .. 0.66
   2 ?   13.5   0.8   1.6e-05     0.057      23      74 ..      99     150 ..      79     166 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.38
     V-set_2 54 siknvklCqaqls 66
                  +n+++Cq+++ 
  EFC38512.1 44 NFNNQEFCQVKFE 56
                4567777776654 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 1.6e-05
     V-set_2  23 petvqqfkmqLlkgkevlCdLtktkesgnavsiknvklCqaqlsnnsvsffL 74 
                  +++++++ +++ + +v+ +L k ++s ++ +i +++ C+ +l+n+s  + L
  EFC38512.1  99 IQKIEEMERRIYEQSQVISNLLKENQSLKTRKIGKPTACRKKLTNQSKQMTL 150
                 456889999*************************************987665 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.4   0.00012      0.42       9      56 ..      94     145 ..      86     167 .. 0.64
   2 ?    1.0   0.0      0.19   6.8e+02      35      52 ..     214     231 ..     198     239 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00012
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH....HHHHHHHHXXXX CS
        YabA   9 kleeleeqleelleeleelkeelaelleenaeLele....neklrerleeee 56 
                 ++++l +++ee+ +++ e  + +++ll+en++L++      +  r++l++++
  EFC38512.1  94 QVSSLIQKIEEMERRIYEQSQVISNLLKENQSLKTRkigkPTACRKKLTNQS 145
                 6777888888888888888888888888888887763333344444443222 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.19
                 HHHHHHHHHHHHHHHHHH CS
        YabA  35 leenaeLeleneklrerl 52 
                 ++e ++L  en+++++  
  EFC38512.1 214 CDEYKKLFKENQHIKTSE 231
                 455666666666666544 PP

>> Baculo_LEF-10  Baculovirus late expression factor 10 (LEF-10)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.044   1.6e+02      21      65 ..     110     153 ..      96     162 .. 0.77
   2 ?    8.4   1.2   0.00066       2.4      12      38 ..     163     191 ..     156     197 .. 0.76

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.044
  Baculo_LEF-10  21 vdnkYlilnvldqetdelRrlClGeidalltdaaaqaeamldass 65 
                     +   +i n l +e++ l+   +G+  a+  +   q+  m    +
     EFC38512.1 110 YEQSQVISNLL-KENQSLKTRKIGKPTACRKKLTNQSKQMTLVQE 153
                    56667899999.9***************99988888888865444 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00066
  Baculo_LEF-10  12 giLkDnlfLvd...nkYlilnvldqetdel 38 
                    g+   n +Lv+   n+Y+i+nv+ ++ de+
     EFC38512.1 163 GVGDLNQYLVNwrgNQYVIINVF-KNRDEI 191
                    555568889987779********.777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1758  (0.0980534); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.56
# Mc/sec: 1380.17
//
Query:       EFC38513.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.004   17.7   1.2     0.0075   16.9   1.2    1.4  1  SlyX      SlyX
     0.0076   16.4   0.3      0.011   15.9   0.3    1.3  1  RP-C_C    Replication protein C C-terminal region
  ------ inclusion threshold ------
      0.024   14.7   0.5      0.036   14.2   0.5    1.3  1  UPF0242   Uncharacterised protein family (UPF0242) N-terminus
      0.051   13.7   2.6      0.082   13.0   2.6    1.3  1  ADIP      Afadin- and alpha -actinin-Binding
      0.069   12.9   1.1       0.12   12.1   1.1    1.4  1  DivIC     Septum formation initiator


Domain annotation for each model (and alignments):
>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   1.2   2.1e-06    0.0075      20      64 ..      86     131 ..      82     133 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 2.1e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXXX.XXXXX CS
        SlyX  20 eeLndvvaeqqqqidrlqrqlrllaerlkeleessgasea.eeepP 64 
                 ++Ln+++ +qq +i+rl ++  ll+++ ++++++s++++  + + P
  EFC38513.1  86 NRLNAEIERQQSEISRLVQENVLLKRKKRKVDTQSNSTQPtNSPQP 131
                 78********************************998777344446 PP

>> RP-C_C  Replication protein C C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.3     3e-06     0.011       7      80 ..      67     142 ..      63     207 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 3e-06
      RP-C_C   7 qrfralverlprkatlaeleelleelealreevenal..esalkaenssanesqnerhiqnsnpdsssesepasek 80 
                 + + ++ ++l+r++ ++e+++l +e+e  + e+++++  +  lk+++++  ++ n  + +ns + s++ s  +s+ 
  EFC38513.1  67 TSVGQMKQSLKRTSPVDEFNRLNAEIERQQSEISRLVqeNVLLKRKKRKVDTQSNSTQPTNSPQPSHTSSRASSSP 142
                 6678999******************************654456788888888888888888888655555433333 PP

>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.5     1e-05     0.036      76     132 ..      62     119 ..      19     129 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1e-05
     UPF0242  76 klteldeglktkeealeelq..eeeeeLkeeldakeeelerlkeenqqLqekleaiaed 132
                  +te+  ++ + +++l+     +e ++L+ e++ +++e+ rl +en  L+ k+ ++  +
  EFC38513.1  62 SVTEQT-SVGQMKQSLKRTSpvDEFNRLNAEIERQQSEISRLVQENVLLKRKKRKVDTQ 119
                 566666.8899999999875448999************************998876554 PP

>> ADIP  Afadin- and alpha -actinin-Binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   2.6   2.3e-05     0.082      55     103 ..      78     126 ..      70     138 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.3e-05
        ADIP  55 reslnetirkleaeierlqskierlktqleqlerelalvqakerqlekk 103
                 r+s  ++ ++l+aeier+qs+i+rl +++  l+r+   v  + ++++ +
  EFC38513.1  78 RTSPVDEFNRLNAEIERQQSEISRLVQENVLLKRKKRKVDTQSNSTQPT 126
                 6666678899******************999999998888888877755 PP

>> DivIC  Septum formation initiator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.1   3.5e-05      0.12      19      50 ..      85     116 ..      79     121 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.5e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC- CS
       DivIC  19 ykqlkqeiaalqaelaklkaeneeLeaevkdL 50 
                 + +l++ei+++q e+ +l +en  L+++ ++ 
  EFC38513.1  85 FNRLNAEIERQQSEISRLVQENVLLKRKKRKV 116
                 6789*********************9998877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1571  (0.0876234); expected 358.6 (0.02)
Passed bias filter:                      623  (0.0347482); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.55
# Mc/sec: 1410.65
//
Query:       EFC38514.1  [L=523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.7e-10   40.1   0.4    1.1e-09   38.2   0.4    2.1  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2   0.4     6e-14   1.1e-09       3     120 ..     390     507 ..     388     508 .. 0.91

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 6e-14
                  HHHHHHCTTT..SSEEEEEEECTT.TEEEEEESS-HHHHHHHHHHTTT-EEEEEEEEEECCSECCEEEEEEEEE--TTS-HHHHHHHHHHHHHHHHHC CS
  Cofilin_ADF   3 eafkelksgk.ktkyilfkidddk.eeivveeegetyeelreelpeseprYavydveyehddeskrsklvfIswvPdsapikqkmlyasskdalkkel 98 
                  +a++el++++ +++y+++++d+++ + +++ ++g++++e ++ l  +++  ++++v   + d+ krsk++ I++++d+++  ++ ++a++ + + + +
   EFC38514.1 390 AAYNELRDEQsDISYAIIEYDEKDkKLLKLFKKGTSFDECCSLLLPDKAYHILLRVIACELDNVKRSKYLCITFMGDEVKAITRGKVAANINVVADHF 487
                  69******99***********98768899**********999997779********7666677*********************************99 PP

                  TTSEEEEEE-CGGCCSHHHHHH CS
  Cofilin_ADF  99 kgisveieatdldelteeelke 120
                    ++  +++ d++ ++ee +++
   EFC38514.1 488 -ALNP-LHIKDKSKIKEEVIEK 507
                  .6765.9**********99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3178  (0.177255); expected 358.6 (0.02)
Passed bias filter:                      794  (0.0442858); expected 358.6 (0.02)
Passed Vit filter:                       164  (0.00914719); expected 17.9 (0.001)
Passed Fwd filter:                        53  (0.0029561); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.49u 0.41s 00:00:01.90 Elapsed: 00:00:00.56
# Mc/sec: 2816.14
//
Query:       EFC38515.1  [L=382]
Description: small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-19   69.6   0.0    3.4e-19   69.0   0.0    1.3  1  Ras       Ras family
    9.3e-06   25.2   0.0    1.5e-05   24.6   0.0    1.4  1  Arf       ADP-ribosylation factor family
    1.3e-05   25.4   0.0    2.5e-05   24.5   0.0    1.5  1  Roc       Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.027   14.4   1.2      0.027   14.4   1.2    2.5  3  F-box     F-box domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.0   0.0   7.6e-23   3.4e-19       4     158 ..     196     361 ..     193     365 .. 0.94

  Alignments for each domain:
  == domain 1  score: 69.0 bits;  conditional E-value: 7.6e-23
                 EEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHHHHS CS
         Ras   4 lvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeikrva 101
                 ++G  + G+ts+++    ++F+e y++ +  ++++   ++++k+v le+wD      f++lr+  y+ ++   +++++ s+es+e +   ++ ei+ ++
  EFC38515.1 196 MLGLPGSGRTSMIFTLGYGEFPE-YIPGV-YENFELFYQLEKKKVCLELWDLGCHPGFERLRPHGYTISHLSCVCFSVCSKESLEMAIsCYIPEIRLHK 292
                 79999****************96.89***.9*****************************************************986549********* PP

                 TTTSEEEEEEETTTGGG...........G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHH CS
         Ras 102 eenvpivLvGnKvDlee...........kravsteegeelakelg.lkfletSAktnenveeafeellr 158
                   ++pi+L+G K+D +e           k  +s+eege++a+++g ++++etS  ++ ++e+ +  +++
  EFC38515.1 293 GFSTPIILIGCKIDDRElkfskeslkslKTPISFEEGEAIARNTGcITYIETSSLKKIGLEDFMPVCVK 361
                 *99******************************************9*************9998766665 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.0   3.2e-09   1.5e-05       8      76 ..     186     256 ..     178     356 .. 0.75

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 3.2e-09
                 GTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEE...EEEETTEEEEEEEE-SSGGGGGGGG CS
         Arf   8 lklkkkelrilllGLDnaGKtTilkklkleelvttvPTigfnve...eleiknlkftvwDvGGqeklRplWk 76 
                 + + + ++ + +lGL ++G+t ++  l  +e+ + +P +  n e   +le k++ +++wD+G +    +l  
  EFC38515.1 186 ISK-DLKFNCTMLGLPGSGRTSMIFTLGYGEFPEYIPGVYENFElfyQLEKKKVCLELWDLGCHPGFERLRP 256
                 332.556779*******************************9986667899***********7754444333 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.5   0.0   5.6e-09   2.5e-05       4     119 ..     196     306 ..     193     307 .. 0.78

  Alignments for each domain:
  == domain 1  score: 24.5 bits;  conditional E-value: 5.6e-09
                 EESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHH.HHCHHHH CS
         Roc   4 lvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srs.senlkeW 98 
                 ++G  g+G ts++  +  ++f +++ + +  +f    + +   +    ++kkv l++WD++ +  f+ l+p+ ++ ++l ++++    ++s +  ++ +
  EFC38515.1 196 MLGLPGSGRTSMIFTLGYGEF-PEYIPGVYENFEL--FYQ---L----EKKKVCLELWDLGCHPGFERLRPHGYTISHLSCVCFSvcsKESlEMAISCY 284
                 799999999999999999999.5566655555532..222...2....236799***********************999999986532231356789* PP

                 HHHHHHHCS.SS-EEEEEE-TT CS
         Roc  99 lkelkkvag.kspvilvgnkiD 119
                 + e++ + g ++p+il+g kiD
  EFC38515.1 285 IPEIRLHKGfSTPIILIGCKID 306
                 *****9998577*********9 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   1.2   5.9e-06     0.027       1      43 [.       9      55 ..       9      59 .. 0.73
   2 ?   -1.4   0.0      0.52   2.3e+03      32      45 ..     182     195 ..     181     197 .. 0.87
   3 ?   -3.0   0.8       1.6   7.2e+03      23      30 ..     261     268 ..     259     273 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 5.9e-06
                -HHHHS-HHHHHHHHHTS-HHH....HHHHCTT-HHHHHHHTTHHHH CS
       F-box  1 ftlsrLPsevlrhILerLplsd....llalrrVSkgwrilidsdrlw 43
                +++  L ++ +r+I+++L+  +    ll  + ++   r l+ +d lw
  EFC38515.1  9 MPFCLLNDDMWREIFRFLDIYSlgnlLLTSMNTCPFSRYLLLEDDLW 55
                7999******************5555555555555555555555555 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.52
                 HHHHHHTTHHHHHH CS
       F-box  32 gwrilidsdrlwck 45 
                 +++++ ++++++c+
  EFC38515.1 182 KLKNISKDLKFNCT 195
                 6899*******996 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 1.6
                 HHHHCTT- CS
       F-box  23 llalrrVS 30 
                 +  l++V+
  EFC38515.1 261 ISHLSCVC 268
                 56799999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (382 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       641  (0.0357521); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2140.56
//
Query:       EFC38516.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-49  160.3  38.3    1.4e-05   24.8   0.0   15.5 17  LRR_6     Leucine Rich repeat
    1.1e-31  108.4  37.9    6.1e-09   35.5   0.1    6.8  7  LRR_8     Leucine rich repeat
    1.9e-24   85.3  42.8    0.00031   21.1   0.3    9.4 12  LRR_4     Leucine Rich repeats (2 copies)
    3.4e-08   33.2  13.7      0.035   13.6   0.4    4.0  5  LRR_9     Leucine-rich repeat
    4.1e-08   32.7  25.8         30    5.7   0.0   12.6 13  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
      0.092   13.0   1.0       0.85   10.0   0.0    3.1  5  DUF5471   Family of unknown function (DUF5471)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0         2     6e+03       4      11 ..       3      10 ..       2      10 .. 0.85
   2 ?   -1.7   0.0       1.4   4.1e+03      15      24 .]      23      32 ..      14      32 .. 0.68
   3 ?    3.3   0.0     0.036   1.1e+02       5      23 ..      37      55 ..      34      56 .. 0.87
   4 !   14.8   0.2   7.1e-06     0.021       5      23 ..      61      79 ..      59      80 .. 0.90
   5 !   16.3   0.0   2.4e-06    0.0073       4      24 .]      84     104 ..      81     104 .. 0.90
   6 !   11.5   0.0   8.1e-05      0.24       5      23 ..     109     127 ..     107     128 .. 0.94
   7 !   24.8   0.0   4.6e-09   1.4e-05       3      24 .]     131     152 ..     129     152 .. 0.90
   8 ?    2.7   0.3     0.057   1.7e+02       3      15 ..     155     167 ..     153     169 .. 0.89
   9 !   10.8   0.0   0.00014      0.42       5      24 .]     181     200 ..     177     200 .. 0.90
  10 !   15.1   0.0     6e-06     0.018       3      24 .]     203     224 ..     201     224 .. 0.90
  11 !   19.7   0.2     2e-07    0.0006       4      24 .]     228     248 ..     227     248 .. 0.96
  12 !   11.1   0.0   0.00011      0.34       4      23 ..     252     271 ..     249     271 .. 0.89
  13 !    9.7   0.0   0.00031      0.93       5      21 ..     277     293 ..     273     295 .. 0.88
  14 !   15.9   0.0   3.2e-06    0.0097       4      24 .]     300     320 ..     297     320 .. 0.91
  15 !   16.5   0.0   2.1e-06    0.0062       3      23 ..     323     343 ..     321     344 .. 0.92
  16 ?    2.5   0.0     0.062   1.9e+02       5      13 ..     349     357 ..     346     361 .. 0.88
  17 ?   -1.4   0.2       1.2   3.5e+03       3      11 ..     369     377 ..     367     378 .] 0.81

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2
       LRR_6  4 hLteLdLs 11
                +L++Ld s
  EFC38516.1  3 NLQSLDFS 10
                799**987 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.4
       LRR_6 15 IgDeGaeaLa 24
                I   G++a+a
  EFC38516.1 23 IVTNGLKAIA 32
                5567999987 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.036
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                L++ +   N+Ig  G++ +
  EFC38516.1 37 LKKINFHRNQIGQNGLQTI 55
                89999999*******9987 PP

  == domain 4  score: 14.8 bits;  conditional E-value: 7.1e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                L  Ld+s+N+Ig eGa+a 
  EFC38516.1 61 LLCLDISCNGIGIEGAKAV 79
                889**************96 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 2.4e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  L+eLd++ NdIgD Ga+ ++
  EFC38516.1  84 QLKELDITANDIGDIGAKYIS 104
                 69***************9875 PP

  == domain 6  score: 11.5 bits;  conditional E-value: 8.1e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L +++NdI+ +Ga+++
  EFC38516.1 109 LTKLYVRYNDINSQGASSI 127
                 99***************98 PP

  == domain 7  score: 24.8 bits;  conditional E-value: 4.6e-09
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt+L++s+N+IgDeG++ ++
  EFC38516.1 131 HQLTKLNISYNNIGDEGMKVIS 152
                 579***************9875 PP

  == domain 8  score: 2.7 bits;  conditional E-value: 0.057
       LRR_6   3 thLteLdLsgNdI 15 
                  hLt+L++  N+I
  EFC38516.1 155 KHLTKLSVHNNHI 167
                 69*********99 PP

  == domain 9  score: 10.8 bits;  conditional E-value: 0.00014
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L++s N+Ig eG+e ++
  EFC38516.1 181 LTNLSISENHIGIEGVETIS 200
                 9***************9885 PP

  == domain 10  score: 15.1 bits;  conditional E-value: 6e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt L +s+N+Ig  Ga+ ++
  EFC38516.1 203 SQLTRLKISSNQIGARGAILIS 224
                 679***************9885 PP

  == domain 11  score: 19.7 bits;  conditional E-value: 2e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L++ +N I+DeG+++L+
  EFC38516.1 228 KLTKLSIGSNRINDEGLKSLC 248
                 69******************8 PP

  == domain 12  score: 11.1 bits;  conditional E-value: 0.00011
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 hLt+L   +N+Ig+eG++++
  EFC38516.1 252 HLTKLKADFNQIGNEGVKSI 271
                 89999999*********987 PP

  == domain 13  score: 9.7 bits;  conditional E-value: 0.00031
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt Ld+ gN+I+ +Ga+
  EFC38516.1 277 LTFLDIGGNNISHKGAQ 293
                 99**********99997 PP

  == domain 14  score: 15.9 bits;  conditional E-value: 3.2e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  L++L +s N+Ig++Ga+ ++
  EFC38516.1 300 QLRTLYISENQIGNKGAKLIS 320
                 59***************9985 PP

  == domain 15  score: 16.5 bits;  conditional E-value: 2.1e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 t L+ L+++ N+++DeG++++
  EFC38516.1 323 TQLRILHIRKNELSDEGVKSI 343
                 679****************98 PP

  == domain 16  score: 2.5 bits;  conditional E-value: 0.062
       LRR_6   5 LteLdLsgN 13 
                 LteLdL+ N
  EFC38516.1 349 LTELDLREN 357
                 9*****988 PP

  == domain 17  score: -1.4 bits;  conditional E-value: 1.2
       LRR_6   3 thLteLdLs 11 
                 ++L++L ++
  EFC38516.1 369 STLKSLKIT 377
                 89***9886 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1      0.82   2.5e+03      24      33 ..       1      10 [.       1      20 [. 0.74
   2 !   10.5   1.3   0.00013      0.39       6      61 .]      16      71 ..      11      71 .. 0.89
   3 !   35.5   0.1     2e-12   6.1e-09       2      61 .]      84     143 ..      83     143 .. 0.98
   4 !   31.0   3.2   5.4e-11   1.6e-07       2      61 .]     156     215 ..     155     215 .. 0.97
   5 !   25.6   2.3   2.5e-09   7.5e-06       1      61 []     203     263 ..     203     263 .. 0.98
   6 !   29.8   1.4   1.3e-10   3.8e-07       2      61 .]     276     335 ..     275     335 .. 0.97
   7 !   15.0   1.0   5.1e-06     0.015       2      52 ..     324     375 ..     323     376 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.82
                -TT--EEE-- CS
       LRR_8 24 lsnLkvLdLs 33
                ++nL++Ld s
  EFC38516.1  1 MKNLQSLDFS 10
                5778888776 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00013
                EE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  6 LdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                L+ ++N++   + +a   l++Lk ++  +N++     +++s++++L  Ld+s N +
  EFC38516.1 16 LSYNHNYIVTNGLKAIAELKQLKKINFHRNQIGQNGLQTISQFNQLLCLDISCNGI 71
                555788899999999999****************************9999998865 PP

  == domain 3  score: 35.5 bits;  conditional E-value: 2e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L++Ld++ N + +++ +  ++++ L+ L+ ++N +++  + ++  L++L++L++s+N++
  EFC38516.1  84 QLKELDITANDIGDIGAKYISQMKELTKLYVRYNDINSQGASSIGELHQLTKLNISYNNI 143
                 79********************************************************97 PP

  == domain 4  score: 31.0 bits;  conditional E-value: 5.4e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+++nN++++ + ++ +++++L+ L++s+N +     +++s+L++L+ L +s+N++
  EFC38516.1 156 HLTKLSVHNNHINVGSSQFISQMKQLTNLSISENHIGIEGVETISQLSQLTRLKISSNQI 215
                 8*************************************999*****************98 PP

  == domain 5  score: 25.6 bits;  conditional E-value: 2.5e-09
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++Lt+L +s+N++ + +    ++l +L+ L++++N+++    +++  L++L++L  + N++
  EFC38516.1 203 SQLTRLKISSNQIGARGAILISKLDKLTKLSIGSNRINDEGLKSLCRLKHLTKLKADFNQI 263
                 58*********************************************************97 PP

  == domain 6  score: 29.8 bits;  conditional E-value: 1.3e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt Ld+  N++++ + ++ ++l++L++L++s+N++    ++ +s L++Lr L+++ N L
  EFC38516.1 276 QLTFLDIGGNNISHKGAQFINQLKQLRTLYISENQIGNKGAKLISELTQLRILHIRKNEL 335
                 7999*****************************************************987 PP

  == domain 7  score: 15.0 bits;  conditional E-value: 5.1e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-. CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLr 52 
                 +L++L++++N l++ + ++   +++L++LdL++N  +t+  ++ +s L+sL+
  EFC38516.1 324 QLRILHIRKNELSDEGVKSILLMKQLTELDLRENyDITVRMENQLSTLKSLK 375
                 89********************************999997789999888885 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.5       0.1     3e+02      22      32 ..       1      11 [.       1      23 [. 0.71
   2 !    7.6   0.5    0.0017       5.2       1      36 [.      35      71 ..      35      75 .. 0.78
   3 !   10.4   0.1   0.00024      0.72       4      41 ..      62      97 ..      59     101 .. 0.75
   4 !   12.6   0.0   4.7e-05      0.14       2      39 ..      84     119 ..      83     128 .. 0.88
   5 !   15.9   0.2   4.5e-06     0.014       2      36 ..     108     143 ..     107     148 .. 0.84
   6 !   21.0   0.6   1.1e-07   0.00033       2      36 ..     132     167 ..     131     177 .. 0.88
   7 !   18.3   0.8   7.8e-07    0.0023       1      36 [.     155     191 ..     155     196 .. 0.80
   8 !   15.7   0.5     5e-06     0.015       1      36 [.     179     215 ..     179     218 .. 0.83
   9 !   13.5   0.6   2.5e-05     0.075       2      37 ..     228     264 ..     227     270 .. 0.72
  10 !   13.0   0.2   3.6e-05      0.11       1      34 [.     251     286 ..     251     290 .. 0.82
  11 !   21.1   0.3     1e-07   0.00031       1      37 [.     275     312 ..     275     316 .. 0.84
  12 !   15.7   1.0     5e-06     0.015       1      41 [.     323     373 ..     323     375 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.1
                -TT--EEE-.- CS
       LRR_4 22 lpnLkeLdLsg 32
                ++nL++Ld s 
  EFC38516.1  1 MKNLQSLDFST 11
                78999999854 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0017
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++++++ Nq+   +l  ++++ +L  Ld+ ++n i
  EFC38516.1 35 KQLKKINFHRNQIGQNGLqtISQFNQLLCLDI-SCNGI 71
                579******99*99766655447*********.55465 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00024
                -EEE--SS---E-S-...HHH.-TT--EEE-.-S-----GGG CS
       LRR_4  4 evLdLsnNqltdipl...lek.lpnLkeLdLsgNnlitdlde 41
                  Ld+s N +  i++     + l +LkeLd++ N    d+ +
  EFC38516.1 62 LCLDISCNGIG-IEGakaV-SeLNQLKELDITAN----DIGD 97
                56999999999.7775532.44*********889....6654 PP

  == domain 4  score: 12.6 bits;  conditional E-value: 4.7e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +L++Ld+  N + di+   +++++ L++L++  N    d+
  EFC38516.1  84 QLKELDITANDIGDIGAkyISQMKELTKLYVRYN----DI 119
                 69******88*******87668*********778....77 PP

  == domain 5  score: 15.9 bits;  conditional E-value: 4.5e-06
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnli 36 
                  L++L+ + N + + +   + + l +L++L++s N +i
  EFC38516.1 108 ELTKLYVRYNDINSQGAssI-GeLHQLTKLNISYN-NI 143
                 7*************999643.44*********999.44 PP

  == domain 6  score: 21.0 bits;  conditional E-value: 1.1e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L++s N++ d +   ++++++L++L++ +Nn i
  EFC38516.1 132 QLTKLNISYNNIGDEGMkvISGMKHLTKLSV-HNNHI 167
                 7*************88898778*********.88888 PP

  == domain 7  score: 18.3 bits;  conditional E-value: 7.8e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+ +nN++   ++  ++++++L+ L++s+N  i
  EFC38516.1 155 KHLTKLSVHNNHINVGSSqfISQMKQLTNLSISEN-HI 191
                 68**********99444453446*********999.44 PP

  == domain 8  score: 15.7 bits;  conditional E-value: 5e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 ++L++L++s N++  i++   +++l +L+ L +s+N +i
  EFC38516.1 179 KQLTNLSISENHIG-IEGvetISQLSQLTRLKISSN-QI 215
                 58*******99*88.666455558*********999.77 PP

  == domain 9  score: 13.5 bits;  conditional E-value: 2.5e-05
                 S--EEE--SS---E-S-HHH-TT--EEE.-..-S---- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLd.L.sgNnlit 37 
                 +L++L++++N++ d +l ++l  Lk+L+ L  ++n+i+
  EFC38516.1 228 KLTKLSIGSNRINDEGL-KSLCRLKHLTkLkADFNQIG 264
                 8************9666.43666666655443566775 PP

  == domain 10  score: 13.0 bits;  conditional E-value: 3.6e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++L    Nq+   +   + +l++L+ Ld+ gNn
  EFC38516.1 251 KHLTKLKADFNQIGNEGVksIIQLKQLTFLDIGGNN 286
                 589******99***777776447*********9994 PP

  == domain 11  score: 21.1 bits;  conditional E-value: 1e-07
                 SS--EEE--SS---.E-S-.HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqlt.dipl.leklpnLkeLdLsgNnlit 37 
                 ++L++Ld+++N+++ +    +++l++L++L++s+N +i+
  EFC38516.1 275 KQLTFLDIGGNNIShKGAQfINQLKQLRTLYISEN-QIG 312
                 58************875554556*********999.775 PP

  == domain 12  score: 15.7 bits;  conditional E-value: 5e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S........-----GGG CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgN........nlitdlde 41 
                 ++L++L+++ N l+d +    l  +++L+eLdL +N        n++++l +
  EFC38516.1 323 TQLRILHIRKNELSDEGVksiLL-MKQLTELDLRENyditvrmeNQLSTLKS 373
                 68*************99998777.*********7786666776777766655 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   0.7     5e-05      0.15      39     128 ..      32     122 ..      12     138 .. 0.85
   2 !   12.5   0.2   2.6e-05     0.079      41     128 ..     130     218 ..     123     230 .. 0.81
   3 !   13.6   0.4   1.2e-05     0.035      42     146 ..     179     281 ..     167     283 .. 0.77
   4 !    7.4   0.2   0.00093       2.8      63     143 ..     226     302 ..     222     302 .. 0.64
   5 !   12.0   1.3   3.6e-05      0.11      42     123 ..     275     357 ..     272     375 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5e-05
       LRR_9  39 atldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 a l q+  i++  n+i +  l+ +  +++l +l ++ n i   + +    l +l+el +t n + +++  + + ++k+l+ l +  n + ++
  EFC38516.1  32 AELKQLKKINFHRNQIGQngLQTISQFNQLLCLDISCNGIGIEGAKAVSELNQLKELDITANDIGDIGA-KYISQMKELTKLYVRYNDINSQ 122
                 6799***********96544999*****************9999999999*****************99.999999**99999888877665 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 2.6e-05
       LRR_9  41 ldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 l q+  +++s n+i +  +  +  +k l  l++ nn i   + ++   + +l++l +++n++  +  ++ + +l++l+ l + +n + ++
  EFC38516.1 130 LHQLTKLNISYNNIGDegMKVISGMKHLTKLSVHNNHINVGSSQFISQMKQLTNLSISENHIG-IEGVETISQLSQLTRLKISSNQIGAR 218
                 667788888888885423677778999999********99999999999************96.56678899999999998888887665 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 1.2e-05
       LRR_9  42 dqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyk 138
                  q+  + +s+n i    ++ +  l +l  l +++n+i   +  l   l +l++l + +n++++      l sl +l+ l+ lk+   +  +     i +
  EFC38516.1 179 KQLTNLSISENHIgiEGVETISQLSQLTRLKISSNQIGARGAILISKLDKLTKLSIGSNRINDE----GLKSLCRLKHLTKLKADFNQIGNEGVKSIIQ 273
                 6777788899975327899999*************************************99874....4455555555555566666666666667777 PP

       LRR_9 139 lkqlrlld 146
                 lkql+ ld
  EFC38516.1 274 LKQLTFLD 281
                 88888777 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.00093
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqelad..ldPlaslkklellsllknpvtnkkeyrlyviyklkqlr 143
                 l +l  l++ +nri    egl+ +l +l++l   +  ++++++  ++ +++lk+l++l +  n +++k       i++lkqlr
  EFC38516.1 226 LDKLTKLSIGSNRIND--EGLK-SLCRLKHLTKLKADFNQIGNegVKSIIQLKQLTFLDIGGNNISHK---GAQFINQLKQLR 302
                 6789999999999864..5554.556666666666666666551246666667666666666666555...556777777776 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 3.6e-05
       LRR_9  42 dqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                  q+  +d+  n+i +   + +  lk+l+tl++++n+i + + +l   l +l+ l + +nel + + ++ +  +k+l+ l l +n
  EFC38516.1 275 KQLTFLDIGGNNISHkgAQFINQLKQLRTLYISENQIGNKGAKLISELTQLRILHIRKNELSDEG-VKSILLMKQLTELDLREN 357
                 56666677777775411233467889999999999999999999999999999999999998865.477778888888877665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.27   8.1e+02       1      12 [.       3      21 ..       3      32 .. 0.71
   2 ?    0.8   0.5      0.42   1.3e+03       2      19 ..      37      54 ..      36      76 .. 0.65
   3 ?    4.7   0.0     0.021        63       1      20 [.      84     103 ..      84     106 .. 0.85
   4 ?    2.1   0.0      0.15   4.6e+02       2      21 ..     109     128 ..     108     130 .. 0.79
   5 ?    5.6   0.0     0.011        32       1      14 [.     132     145 ..     132     154 .. 0.83
   6 ?    1.2   0.4      0.31   9.1e+02       1      13 [.     156     172 ..     156     191 .. 0.70
   7 ?   -1.1   0.0       1.8   5.3e+03       2      13 ..     181     192 ..     180     202 .. 0.73
   8 ?    0.9   0.0      0.38   1.1e+03       2      12 ..     205     215 ..     204     226 .. 0.79
   9 ?    3.9   0.4      0.04   1.2e+02       1      22 [.     228     249 ..     228     260 .. 0.86
  10 !    5.7   0.0    0.0099        30       2      18 ..     277     293 ..     276     298 .. 0.82
  11 ?    5.2   0.0     0.015        44       1      20 [.     300     319 ..     300     322 .. 0.79
  12 ?    3.8   0.1     0.043   1.3e+02       1      20 [.     324     343 ..     324     345 .. 0.85
  13 ?    1.2   0.0       0.3     9e+02       1      11 [.     348     358 ..     348     369 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.27
       LRR_1  1 nLrhLd.......Lsnnpl 12
                nL++Ld       Ls+n++
  EFC38516.1  3 NLQSLDfstttneLSYNHN 21
                89***95555555677765 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.42
       LRR_1  2 LrhLdLsnnpllglppns 19
                L++++  +n++++ + ++
  EFC38516.1 37 LKKINFHRNQIGQNGLQT 54
                778887777764443333 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.021
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++Ld++ n ++++++ ++
  EFC38516.1  84 QLKELDITANDIGDIGAKYI 103
                 59*********999988776 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.15
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L++L++++n + + +++s+ 
  EFC38516.1 109 LTKLYVRYNDINSQGASSIG 128
                 899*******9777777665 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++L++s+n++++
  EFC38516.1 132 QLTKLNISYNNIGD 145
                 599*******9965 PP

  == domain 6  score: 1.2 bits;  conditional E-value: 0.31
       LRR_1   1 nLrhLdLsnnpl....l 13 
                 +L++L + nn++    +
  EFC38516.1 156 HLTKLSVHNNHInvgsS 172
                 58999999999844332 PP

  == domain 7  score: -1.1 bits;  conditional E-value: 1.8
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L +s n+++
  EFC38516.1 181 LTNLSISENHIG 192
                 888999999983 PP

  == domain 8  score: 0.9 bits;  conditional E-value: 0.38
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L +s+n++
  EFC38516.1 205 LTRLKISSNQI 215
                 99*******98 PP

  == domain 9  score: 3.9 bits;  conditional E-value: 0.04
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L +++n++ + +  s++ 
  EFC38516.1 228 KLTKLSIGSNRINDEGLKSLCR 249
                 79*********98877777765 PP

  == domain 10  score: 5.7 bits;  conditional E-value: 0.0099
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L+ Ld+++n++++++++
  EFC38516.1 277 LTFLDIGGNNISHKGAQ 293
                 999*******9888766 PP

  == domain 11  score: 5.2 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr+L++s n+++++++  +
  EFC38516.1 300 QLRTLYISENQIGNKGAKLI 319
                 59*********988777665 PP

  == domain 12  score: 3.8 bits;  conditional E-value: 0.043
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr L+++ n l++ +  s+
  EFC38516.1 324 QLRILHIRKNELSDEGVKSI 343
                 59**********88877765 PP

  == domain 13  score: 1.2 bits;  conditional E-value: 0.3
       LRR_1   1 nLrhLdLsnnp 11 
                 +L++LdL+ n 
  EFC38516.1 348 QLTELDLRENY 358
                 599****9886 PP

>> DUF5471  Family of unknown function (DUF5471)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       3.6   1.1e+04      37      67 ..       9      39 ..       4      40 .. 0.69
   2 ?   -2.9   0.0       2.9   8.6e+03      30      47 ..      81      98 ..      77     113 .. 0.70
   3 ?   -3.0   0.0       3.1   9.2e+03       5      18 ..     106     119 ..     100     125 .. 0.74
   4 ?   -1.4   0.0         1     3e+03      17      29 ..     233     245 ..     222     254 .. 0.68
   5 ?   10.0   0.0   0.00028      0.85      14      47 ..     303     338 ..     292     344 .. 0.73

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.6
     DUF5471 37 lairsneladsastkvteaarvanqaqqlsk 67
                ++  +nel+      vt+  +     +ql k
  EFC38516.1  9 FSTTTNELSYNHNYIVTNGLKAIAELKQLKK 39
                5566788888888888887777777777766 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.9
     DUF5471 30 eatqsralairsnelads 47
                e  q + l i +n++ d 
  EFC38516.1 81 ELNQLKELDITANDIGDI 98
                666777788888887775 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 3.1
     DUF5471   5 ikklGqllvrmynv 18 
                 +k l +l vr  ++
  EFC38516.1 106 MKELTKLYVRYNDI 119
                 57888888886555 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 1
     DUF5471  17 nveakrlndeark 29 
                  + + r+nde  k
  EFC38516.1 233 SIGSNRINDEGLK 245
                 5667899999776 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00028
     DUF5471  14 rmynveakrlndear..keatqsralairsnelads 47 
                  +y  e +  n  a+   e tq r l ir nel+d 
  EFC38516.1 303 TLYISENQIGNKGAKliSELTQLRILHIRKNELSDE 338
                 46666766667777644699**************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       609  (0.0339673); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2207.91
//
Query:       EFC38517.1  [L=460]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      1e-75  255.3   0.2    1.1e-75  255.2   0.2    1.0  1  p450           Cytochrome P450
  ------ inclusion threshold ------
      0.068   12.7   0.6        0.1   12.1   0.6    1.2  1  Lipoprotein_2  Borrelia lipoprotein


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  255.2   0.2   1.2e-79   1.1e-75      29     462 ..       5     452 ..       1     453 [. 0.87

  Alignments for each domain:
  == domain 1  score: 255.2 bits;  conditional E-value: 1.2e-79
                 HHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHHTSHSTT.THHHHHHHHHHHHH CS
        p450  29 lqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltptltsfgkl.sleelveeeaedlv 126
                 +  k   i+r+ + ++++v++s+ +++ke+l +k ++f+++  ++ ++   k f  + + + + ++wk ++r++ p++ s+ +l  ++++++e+ +++v
  EFC38517.1   5 FGDKKTGIVRMSMLGRNIVIVSHKDHIKELLLTKEKFFKKY--PPSYEA-FKIFGDNILSMLEADTWKPHHRICSPAFSSN-NLkFVTKVTCESFDEMV 99 
                 55566679**************************9999885..555555.55899999999999*****************.8878999*****99998 PP

                 H.HHHCCCCHCS.EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHH...HHHCHHHHCCCCCHHHTCCSCHHHH..HHHHHHHHHHH CS
        p450 127 e.klrkkagess.elditellskaaldvigsilFgarfdlledeklselvkaveelss...llskssvqllllfpllkylptkllr..klkeavkklkd 218
                 + +++k  ++++  + + ++ s+ +l v+g+ +Fg  f+ l ++++++ +  +++ ++        ++++l   p+lkyl         +++a + ++ 
  EFC38517.1 100 AhRWEKLPDANGsFILPIDDYSDLTLQVLGRSIFGLDFG-LFSDDPTKNESNFRKSLEillTKGILFKRFLSETPILKYLYPYVMSyfGVDKALELVST 197
                 537999999999888999*********************.666665555555555555221223345566666667777766554411457899***** PP

                 HHHHHHHHHHHCHCHC...SCSSCSHHHHHHHHC.........TTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHH CS
        p450 219 lldklieerretldsa...kksrrdfldalllak.........kekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEide 305
                  ldk+i+e++e  +++     +++d+l  ++++          ++k+++  l+++e++ + + + +aG dT+ss ++wa y Lak+P++q+kl+ +i++
  EFC38517.1 198 KLDKIIQEKKEIYENDkleGTEHNDLLTMMIETNssltesqldNTKSEHGGLTKDEIKSNSFIFSLAGNDTSSSLSQWASYVLAKRPDIQQKLYDNIQN 296
                 ***************999966899999999999999999888644444479************************************************ PP

                 HCCTTTT-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTS.CTESSCTT-- CS
        p450 306 vlgdkreptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRFldekg.nskrksfafl 403
                 vlgd rept+dd +kl+y++a+i EtLR h +v  ++ ++++kdv++++++ipk+t ++++l    ++++ ++nP eF+p+RF d++     ++sf+++
  EFC38517.1 297 VLGD-REPTFDDYEKLTYVNAFIMETLRVHGPVG-GIIKVAKKDVELGEFKIPKNTSILLSLAQACNSDKNWENPTEFNPDRFPDAETqLRYQHSFSWM 393
                 ****.68***************************.**************************************************99985669****** PP

                 TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSCSSEEESSSSEEE CS
        p450 404 PFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileksglllppkpiklk 462
                 PF++  R CiG ++A  el+ ++++l++++++el +++++ pi +  +++++p ++k+k
  EFC38517.1 394 PFSMANRKCIGYKFALIELNAIFTKLVRKYKLELLNDESVDPIGKAVAVTIRPTNLKIK 452
                 ************************************99999999988888888888776 PP

>> Lipoprotein_2  Borrelia lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.6   1.2e-05       0.1      34      92 ..     188     252 ..     182     272 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.2e-05
  Lipoprotein_2  34 vgetvesvktkLnkivaelke.ekkknaegteks.veklvegkldkive....gakkaseaalge 92 
                    v +++e v+tkL+ki +e ke +++ + egte + + +++ ++++ + e    ++k  + + +++
     EFC38517.1 188 VDKALELVSTKLDKIIQEKKEiYENDKLEGTEHNdLLTMMIETNSSLTEsqldNTKSEHGGLTKD 252
                    8999***********999865389**********************9997666555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.34s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 2561.59
//
Query:       EFC38518.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.03   14.6   8.9      0.048   13.9   6.6    2.1  2  Shisa     Wnt and FGF inhibitory regulator


Domain annotation for each model (and alignments):
>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0     0.029   5.2e+02     128     161 ..      58      95 ..      18     128 .. 0.51
   2 ?   13.9   6.6   2.7e-06     0.048      81     114 ..     212     249 ..     185     251 .] 0.58

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.029
       Shisa 128 alaev..gpivte..ttsattvvhsrysepqqssssss 161
                  ++++  ++ +t+  +++ ++ ++  +s++ +++ ss+
  EFC38518.1  58 TKLNSfiQTAKTRysQEARQNFINQLESNNKHTRQSST 95 
                 22222222222222222223333333333333333333 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 2.7e-06
       Shisa  81 d.......iyvpvlivktifivfvivgvvvivcccgclkkk 114
                 +       i + v++++ ++  f+i++ v++++cc+   k+
  EFC38518.1 212 SpgsassgIVAGVVVGGAMILGFIILILVCCCVCCC---KM 249
                 122233348899999999999999997666555544...44 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1675  (0.0934241); expected 358.6 (0.02)
Passed bias filter:                      882  (0.049194); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.35s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 1414.80
//
Query:       EFC38519.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.011   15.9   8.4      0.011   15.9   8.4    1.7  3  Shisa     Wnt and FGF inhibitory regulator
       0.12   12.4   2.4       0.42   10.7   2.4    1.9  1  ETRAMP    Malarial early transcribed membrane protein (ETRAMP
       0.78    7.6   8.7        1.2    7.0   8.7    1.2  1  Prominin  Prominin
       0.82    9.5   6.6        1.6    8.6   2.1    2.1  2  RIFIN     Rifin
        2.3    9.2   5.1       0.63   11.0   1.4    1.9  2  EphA2_TM  Ephrin type-A receptor 2 transmembrane domain


Domain annotation for each model (and alignments):
>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       1.5   5.4e+03      57     171 ..      27      41 ..       7      62 .. 0.49
   2 ?   -3.2   0.0       2.4   8.7e+03     122     150 ..      59      86 ..      43     116 .. 0.53
   3 ?   15.9   8.4   3.2e-06     0.011      89     117 ..     206     237 ..     174     242 .. 0.56

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.5
       Shisa  57 teeslktgreekekqlgsalevpkdiyvpvlivktifivfvivgvvvivcccgclkkkqrekrpgrenlssalaevgpivtettsattvvhsrysepqq 155
                  +++ + g+                                                                                          
  EFC38519.1  27 IKQWSSYGSS----------------------------------------------------------------------------------------- 36 
                 2222222222......................................................................................... PP

       Shisa 156 ssssssypgatnqgyq 171
                            +++yq
  EFC38519.1  37 -----------ENNYQ 41 
                 ...........33333 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 2.4
       Shisa 122 renlssalaevgpivtettsattvvhsry 150
                 r   ss+la    i+ +  ++t+ v s y
  EFC38519.1  59 RVDFSSQLARES-IKRKALDTTLLVGSWY 86 
                 444444444442.2232345555555555 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 3.2e-06
       Shisa  89 vktifivfvivg...vvvivcccgclkkkqre 117
                 ++ ++iv+v+v+   + ++vccc+c+   ++e
  EFC38519.1 206 IAGVVIVIVLVIvfcIACCVCCCCCMAEEEEE 237
                 33444444444400044555556665555444 PP

>> ETRAMP  Malarial early transcribed membrane protein (ETRAMP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   2.4   0.00012      0.42       6      30 ..     213     237 ..     209     241 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00012
      ETRAMP   6 vllffafLlavnlltpeslcdevnk 30 
                 ++l+++f++a+++++++++++e+++
  EFC38519.1 213 IVLVIVFCIACCVCCCCCMAEEEEE 237
                 4899999999999999999998875 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   8.7   0.00033       1.2      92     125 ..     199     232 ..     168     240 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00033
    Prominin  92 GllvcvvilllliilmPliGlcfccCRCcrrCgg 125
                 G +  + i+ ++i+++ +i +c +cC Cc  C  
  EFC38519.1 199 GTITSASIAGVVIVIVLVIVFCIACCVCCCCCMA 232
                 6666777777777777777666666666666654 PP

>> RIFIN  Rifin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.2     0.019        68     169     210 ..      21      65 ..       2      96 .. 0.66
   2 ?    8.6   2.1   0.00043       1.6     268     300 ..     190     221 ..     176     222 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.019
       RIFIN 169 sel..kekklesl.itatnyknvtslvkaikeeyeescllklkks 210
                 +++  + k+++s+  +++ny+  ++l+k  ke y+e + ++++++
  EFC38519.1  21 QTVnnRIKQWSSYgSSENNYQAIEELIKKSKEMYSEEMRVDFSSQ 65 
                 222223377888855889999999999999999887766633333 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00043
       RIFIN 268 aveattaslqtaiiasivaivvIvLimvIIYLi 300
                 av+  t+++  +i+ + +a vvIv+++vI++ i
  EFC38519.1 190 AVTI-TYNSPGTITSASIAGVVIVIVLVIVFCI 221
                 4444.44455567777788899********987 PP

>> EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1         5   1.8e+04       3      13 ..     121     131 ..     117     138 .. 0.53
   2 ?   11.0   1.4   0.00017      0.63       4      32 ..     204     232 ..     201     241 .. 0.43

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 5
    EphA2_TM   3 aaavaglvllv 13 
                 +++v+g+ ll 
  EFC38519.1 121 TVSVVGVSLLT 131
                 34444444443 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00017
    EphA2_TM   4 aavaglvllvilvilvlvlvrrrsknrkq 32 
                 a++ag+v++++lvi++ + +  ++++  +
  EFC38519.1 204 ASIAGVVIVIVLVIVFCIACCVCCCCCMA 232
                 55555555555444443333333333222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1711  (0.095432); expected 358.6 (0.02)
Passed bias filter:                      792  (0.0441742); expected 358.6 (0.02)
Passed Vit filter:                        87  (0.00485247); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 1361.63
//
Query:       EFC38520.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       373  (0.0208043); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.33s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1120.13
//
Query:       EFC38521.1  [L=301]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.9e-79  265.3   0.6    5.2e-79  264.9   0.6    1.2  1  Gtr1_RagA  Gtr1/RagA G protein conserved region
    1.7e-10   40.6   0.4    3.6e-10   39.6   0.0    1.7  2  Arf        ADP-ribosylation factor family
    7.7e-08   32.6   0.0    2.4e-07   31.0   0.0    1.9  1  Roc        Ras of Complex, Roc, domain of DAPkinase
    4.9e-06   26.2   0.2    1.1e-05   25.0   0.0    1.7  2  Ras        Ras family
    2.7e-05   23.7   0.1    5.4e-05   22.7   0.1    1.5  1  SRPRB      Signal recognition particle receptor beta subunit
  ------ inclusion threshold ------
      0.019   15.5   0.9      0.053   14.0   0.9    2.1  1  ABC_tran   ABC transporter
       0.15   11.5   0.0       0.39   10.1   0.0    1.7  1  SMC_N      RecF/RecN/SMC N terminal domain
       0.24   10.5   9.6       0.63    9.1   3.3    2.8  2  G-alpha    G-protein alpha subunit


Domain annotation for each model (and alignments):
>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  264.9   0.6   2.3e-82   5.2e-79       1     231 [.       2     228 ..       2     229 .. 0.97

  Alignments for each domain:
  == domain 1  score: 264.9 bits;  conditional E-value: 2.3e-82
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletlk 99 
                 k+LLmGk+gsGKtsmrsi+F+ +++ ++++l+ tidve   +++++n+++nlwDcgGq++++ +y+++ +e+if++v++l+yVfDv+++  ee l++++
  EFC38521.1   2 KLLLMGKNGSGKTSMRSILFAMTSPMECRKLAPTIDVEYIPIKLMENMKVNLWDCGGQQNMMLNYFKNRRESIFSQVNALVYVFDVSTDGDEEVLRDFH 100
                 89*************************************************************************************9989******** PP

   Gtr1_RagA 100 eilealrqyspeakvfvlihKmDliqedereeifeerkeeireeieklekeeiqffaTSiwdeslykAfssivqklipnldvleelLkklaeaieaeev 198
                 e+l+al ++s + kvf+l+hK+D +  +ere+i++++++ei+  +e ++   +++f+TSiwdesly+A+ si ++lip+++ ++++L+++a+++ aeev
  EFC38521.1 101 ESLQALGENSSNTKVFCLLHKTDVLIPSEREKILQRKEKEIMAVAELTD---LTCFRTSIWDESLYRAWGSILNTLIPQINEIKSKLEEFAKICGAEEV 196
                 ******************************************9988877...*********************************************** PP

   Gtr1_RagA 199 lLferstflviatvsskeaeekdasrfekvsei 231
                 +Lferstfl+i+++s+++++ +d +rfek+++i
  EFC38521.1 197 VLFERSTFLLISQWSNEKVT-QDDHRFEKIANI 228
                 ***************66665.889*******98 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.6   0.0   1.6e-13   3.6e-10      15     136 ..       1     133 [.       1     167 [. 0.72
   2 ?   -2.2   0.0       1.1   2.5e+03      97     136 ..     246     285 ..     240     293 .. 0.73

  Alignments for each domain:
  == domain 1  score: 39.6 bits;  conditional E-value: 1.6e-13
                 EEEEEEESTTSSHHH...HH.HHHHHSSCEECSSSSSEEEEEEEE.TTEEEEEEEE-SSGGGG.GGGGG....GCTTESEEEEEEETT...-CTTHHHH CS
         Arf  15 lrilllGLDnaGKtT...il.kklkleelvttvPTigfnveelei.knlkftvwDvGGqeklR.plWkn....YfektdavifvvDsa...dreRleea 100
                 +++ll+G  ++GKt    il  + +  e+ +  PTi  +   ++  +n+k+++wD GGq+++  +++kn     f++++a+++v D++   d+e l++ 
  EFC38521.1   1 MKLLLMGKNGSGKTSmrsILfAMTSPMECRKLAPTIDVEYIPIKLmENMKVNLWDCGGQQNMMlNYFKNrresIFSQVNALVYVFDVStdgDEEVLRDF 99 
                 799***********73334514556789999*****99999888559************9864255554222279***********9755567899999 PP

                 HHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHH CS
         Arf 101 keeLkalleeeelkevallvlaNKqDlpealseeel 136
                 +e L+al e++ + +v  l    K D+    ++e++
  EFC38521.1 100 HESLQALGENSSNTKVFCL--LHKTDVLIPSEREKI 133
                 9****99888887776655..567776544444444 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.1
                 HHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHH CS
         Arf  97 leeakeeLkalleeeelkevallvlaNKqDlpealseeel 136
                 +e  k++++a++ee ++++ ++++++    l++ + + ++
  EFC38521.1 246 MELVKSDFSAFFEEFTMNTFIMVIVSAESKLESEMVKMNI 285
                 6677888888888888888888888877777777666655 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.0   1.1e-10   2.4e-07       1     119 [.       2     123 ..       2     124 .. 0.68

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 1.1e-10
                 EEEEESSTTSSHHHHHHCHCT-CC...C-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGC.....TTTT-HHHHCTSCEEEEEEEGHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkf...sekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqer.....frslhplylreaalailvydsrs 91 
                 K++l+G++g+GKts+ + +   +     +k  +ti v+++  ++     +      +++k+n+WD +Gq++     f++ +++ +++ +++++v+d ++
  EFC38521.1   2 KLLLMGKNGSGKTSMRSILFAMTSpmeCRKLAPTIDVEYIPIKL-----M------ENMKVNLWDCGGQQNmmlnyFKNRRESIFSQVNALVYVFDVST 89 
                 89***********9977766544411146677888888876544.....2......35789********863333367889999999********9444 PP

                 H...HCH...HHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  92 s...enl...keWlkelkkvagkspvilvgnkiD 119
                 +   e l   +e l+ l +++++++v+++  k+D
  EFC38521.1  90 DgdeEVLrdfHESLQALGENSSNTKVFCLLHKTD 123
                 3222344111555555555566678888888887 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.0   5.1e-09   1.1e-05       1     117 [.       2     125 ..       2     161 .. 0.74
   2 ?   -1.9   0.1      0.97   2.2e+03      88     102 ..     223     237 ..     200     284 .. 0.62

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 5.1e-09
                 EEEEEESTTSSHHHH...HHHHHHSSCSSSCTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGG.....GHHHHHHHHTTESEEEEEEETTBHHHHHTH CS
         Ras   1 KlvlvGdsavGKtsl...llrfvkdkFkeeyesTigvdfytkeievd.gkevkleiwDTAGqee.....fkslrelyyrdaegillvyditsresfenv 90 
                 Kl+l+G+++ GKts+   l+  ++    ++  +Ti v+       ++  +++k+++wD  Gq++     fk+ re+ ++++++++ v+d++     e +
  EFC38521.1   2 KLLLMGKNGSGKTSMrsiLFAMTSPMECRKLAPTIDVEYIP----IKlMENMKVNLWDCGGQQNmmlnyFKNRRESIFSQVNALVYVFDVSTDGDEEVL 96 
                 89***********8722145555555567889999555443....33357899*********86555559999*****************999888888 PP

                 HHHHHHHHHHST..TTSEEEEEEETTTGG CS
         Ras  91 kkwveeikrvae..envpivLvGnKvDle 117
                 ++++e ++   e  +n+++  +  K+D+ 
  EFC38521.1  97 RDFHESLQALGEnsSNTKVFCLLHKTDVL 125
                 89998888877766678888888888875 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.97
                 HTHHHHHHHHHHHST CS
         Ras  88 envkkwveeikrvae 102
                 e+++++++++k  ++
  EFC38521.1 223 EKIANITKQFKLSCS 237
                 444444444443333 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.1   2.4e-08   5.4e-05       6     146 ..       3     146 ..       1     152 [. 0.80

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 2.4e-08
                 EEEE-STTSSHHHHHHHHHHSS---B---SS-EEETTG......GGTT-SEEEETT-GCCSHHHHHHHHHH..GGEEEEEEEEETTS-HHH..HHHHHH CS
       SRPRB   6 vllvGlsdsGKTslftrLttdsvkktvtSqessaalkv...ksekgskltliDfPGheklrqklleklkak..sslkglvfvvDStidpke..vkevAE 97 
                 +ll+G   sGKTs+   L   +       +++++  ++   k  ++ k++l D  G++++  + +++ +++  s++ +lv+v D + d  e  +++  E
  EFC38521.1   3 LLLMGKNGSGKTSMRSILFAMTSPMECRKLAPTIDVEYipiKLMENMKVNLWDCGGQQNMMLNYFKNRRESifSQVNALVYVFDVSTDGDEevLRDFHE 101
                 799**********9999988877777777788887777777889******************9999977764467*********888754322677777 PP

                 HHHHHHHHHHHHTT---EEEEEE-TTSTT---HHHHHHHHHHHHHHHHH CS
       SRPRB  98 llyeilliteklkdavdiliACnKqelflakspklikdaLEkElnkiie 146
                  l  +  ++     + +++   +K ++ +  + ++i +  EkE+  + e
  EFC38521.1 102 SLQALGENS----SNTKVFCLLHKTDVLIPSEREKILQRKEKEIMAVAE 146
                 765544333....345555566**********************98865 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.9   2.3e-05     0.053      14      40 ..       3      29 ..       1     299 [. 0.90

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.3e-05
                EEEEESTTSSHHHHHHHHTTSS--SEE CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran 14 vaivGenGaGKStLlkllagllkpteG 40
                + ++G+nG+GK+++ ++l  +++p e 
  EFC38521.1  3 LLLMGKNGSGKTSMRSILFAMTSPMEC 29
                679****************99999664 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   0.00018      0.39      29      49 ..       5      24 ..       2      36 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00018
                EEESTTSSHHHHHHHHHHHCT CS
                xxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 29 ivGpNGSGKsnlldAilFvLG 49
                ++G+NGSGK+++  +ilF + 
  EFC38521.1  5 LMGKNGSGKTSM-RSILFAMT 24
                79********96.68889886 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.5    0.0081        18      24      39 ..       1      16 [.       1      24 [. 0.90
   2 ?    9.1   3.3   0.00028      0.63     186     281 ..      33     124 ..      23     286 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0081
                EEEEEEESTTSSHHHH CS
     G-alpha 24 vkllllGqseSGKsTi 39
                +klll+G+++SGK+++
  EFC38521.1  1 MKLLLMGKNGSGKTSM 16
                69***********986 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00028
                 ----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTC.....CCTTTECEEEEEEEGGGTT-B-SS-TT.SBHHHHHHHHHHCCCC-GGGTTSEEEEEEE- CS
     G-alpha 186 lktvGisetkfevdsklefrivdvgGqrserkkWv.....pffddvdaiiFlvslsefdqvlyedek.vnrleeslklFkeicnnkllkntpiiLflnK 278
                  +t+ ++ + +++ ++++++++d+gGq++   ++      ++f++v+a++++  +s        de+    ++esl+   e  +     nt+++ +l K
  EFC38521.1  33 APTIDVEYIPIKLMENMKVNLWDCGGQQNMMLNYFknrreSIFSQVNALVYVFDVS-----TDGDEEvLRDFHESLQALGENSS-----NTKVFCLLHK 121
                 468889999999999**************97666655555899*********6554.....33343313335666655555444.....4555555555 PP

                 HHH CS
     G-alpha 279 lDi 281
                 +D+
  EFC38521.1 122 TDV 124
                 555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       846  (0.0471861); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 1719.76
//
Query:       EFC38522.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0098   15.9   0.1      0.017   15.1   0.1    1.4  1  DUF4711   Domain of unknown function (DUF4711)
  ------ inclusion threshold ------
       0.06   13.5   0.8       0.19   11.8   0.0    2.1  2  CRA       Circumsporozoite-related antigen (CRA)
       0.11   12.2   0.1       0.11   12.2   0.1    2.5  3  DUF4448   Protein of unknown function (DUF4448)
          1    9.1   6.1        1.8    8.2   0.0    2.9  3  CbtA      Probable cobalt transporter subunit (CbtA)
        2.8    7.3   6.1         12    5.2   0.2    3.3  4  DUF5305   Family of unknown function (DUF5305)


Domain annotation for each model (and alignments):
>> DUF4711  Domain of unknown function (DUF4711)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.1   4.8e-06     0.017     146     219 ..     244     316 ..     227     318 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 4.8e-06
     DUF4711 146 eassetlsttttsitpkekeeekttstddfssedtD..edlkkrqkwsivvKalIavtLLlsgvaiivFvIfEvpc 219
                 ++  ++++ +t+s+t++e+ e+ +  t+ + +++t+  +++ +  k+ ++ K    + L+l+ +a ivF++fEv+ 
  EFC38522.1 244 NTREKRMEDETVSRTEGEHMEKTINWTE-VVKKETErqKNVSRTLKMRVLFKY--YIGLFLGALAGIVFFLFEVAF 316
                 4555678889999999988655555555.444444400444444444555554..567999*************86 PP

>> CRA  Circumsporozoite-related antigen (CRA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   5.3e-05      0.19      44      96 ..     246     296 ..     238     325 .. 0.66
   2 ?   -1.2   0.2      0.56     2e+03       7      22 ..     365     381 ..     363     383 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.3e-05
         CRA  44 kykk.nekevekaeekedeneedridvlkLikelekKeeeliivnKkkkkYksa 96 
                 + k+ ++++v ++e   +e+ e+ i+ ++++k++ +++ ++++  K++ ++k  
  EFC38522.1 246 REKRmEDETVSRTE---GEHMEKTINWTEVVKKETERQKNVSRTLKMRVLFKYY 296
                 22220333444443...7******************************998853 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.56
         CRA   7 lfviilllvv.ycdevk 22 
                 ++++ +++++ y+ ++k
  EFC38522.1 365 FVFMGCFVLLlYNRTIK 381
                 79999****99998876 PP

>> DUF4448  Protein of unknown function (DUF4448)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   3.1e-05      0.11     124     186 ..     184     246 ..     100     249 .. 0.77
   2 ?   -1.1   0.1      0.39   1.4e+03     156     184 ..     351     379 ..     304     383 .. 0.71
   3 ?   -4.0   0.3       3.1   1.1e+04     159     178 ..     468     487 ..     465     489 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 3.1e-05
     DUF4448 124 eveikkGpkVsltkkedlkkledkeseegkkaekyalaialPvvvvvlvlgligfvlwnrkkr 186
                  +++  G  V  ++  ++  + ++ +   +++++++  +alP +v+ ++++ +g++++ +++r
  EFC38522.1 184 MTYWVAGKDVDYENGANSSIYAYPLQYIFTNSKGIVFCVALPFIVFGVLFLCLGYFFVEKNTR 246
                 5556666666666665555444444455578999**************************998 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.39
     DUF4448 156 ekyalaialPvvvvvlvlgligfvlwnrk 184
                 +  ++ i+ P+   ++++g ++++l+nr 
  EFC38522.1 351 RVFIIGISFPISYPFVFMGCFVLLLYNRT 379
                 45567788899999999999999999985 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 3.1
     DUF4448 159 alaialPvvvvvlvlgligf 178
                 ++ ia+   ++++++gli +
  EFC38522.1 468 KILIAISYLLIFIAIGLISY 487
                 57899999999999998865 PP

>> CbtA  Probable cobalt transporter subunit (CbtA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.3     0.019        67      77     128 ..      42      97 ..      28     101 .. 0.68
   2 ?   -3.8   0.6       2.5     9e+03     226     236 ..     145     155 ..     138     182 .. 0.62
   3 ?    8.2   0.0   0.00051       1.8      15     102 ..     229     318 ..     216     328 .. 0.59

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.019
        CbtA  77 anvltgvalglllaavfallegrlgkls....aralalllalagflavvlvPflkl 128
                 +  ++ +a+g+++ ++f++  + ++kl      ++    + + +f+ +v++P ++l
  EFC38522.1  42 GLGVLCAAFGGIFSILFLVPTPVFTKLIhrktLWRFENSWLISMFFGLVFWPLVGL 97 
                 55667777888888888877666655541111455556688888888888888876 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 2.5
        CbtA 226 tqavlWavlGl 236
                 +  v+W+v G+
  EFC38522.1 145 VAHVVWVVFGF 155
                 33344444443 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00051
        CbtA  15 AGllaflvqrlvvePlilaAeayEeaaaaaeaaeaaaeHeh........aeaeepelvsrgvqrtlgtvlanvltgvalglllaavfallegrlgk 102
                  G+l+ ++ +++ve    +    +e  + +e+++ ++            +e+e ++ vsr+++     vl+   +g+ lg+l ++vf l+e ++ +
  EFC38522.1 229 FGVLFLCLGYFFVEKNTREKRMEDETVSRTEGEHMEK---TinwtevvkKETERQKNVSRTLKMR---VLFKYYIGLFLGALAGIVFFLFEVAFLA 318
                 5777777777777777665443333333333333333...1334444434455555666666655...8888888888888888888888766644 PP

>> DUF5305  Family of unknown function (DUF5305)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1      0.02        73      87     135 ..      12      60 ..      10      74 .. 0.87
   2 ?    3.4   0.0     0.012        43      87     160 ..     186     264 ..     184     279 .. 0.55
   3 ?    5.2   0.2    0.0034        12      62     137 ..     242     317 ..     238     335 .. 0.71
   4 ?   -1.8   0.2      0.46   1.6e+03     114     140 ..     466     492 ..     461     497 .. 0.71

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.02
     DUF5305  87 yeikkdetdeengeitetvtvkespslaegilliilgllaliglvvlir 135
                 y++ +++t+  n++it+++++++  s  +++l+++++ ++ i+ +++ +
  EFC38522.1  12 YQLLDNTTSLVNDTITNSTSTSDIISAQNAGLGVLCAAFGGIFSILFLV 60 
                 77788888899999***********999999999999999999888765 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.012
     DUF5305  87 yeikkdetd...eengeitetvtvkespslae..gilliilgllaliglvvlirriiftssk...aekyelelekilkeYde 160
                 y++ ++  d     n++i+++   +      +  gi++++++ ++++g+ +l + ++f  ++   + +++ + +++  e+ e
  EFC38522.1 186 YWVAGKDVDyenGANSSIYAYPLQYIFT---NskGIVFCVALPFIVFGVLFLCLGYFFVEKNtreKRMEDETVSRTEGEHME 264
                 5665555552223344444443333333...344577777777777777777777777766633355666666666666655 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0034
     DUF5305  62 egeidgesieesktsrlpiplteqtyeikkdetdeengeitetvtvkespslaegilliilgllaliglvvlirri 137
                 e ++ ++++e++++sr++ ++ e+t++ ++  ++e++++ +++ t k    +++ i+l++ +l++++++ + + + 
  EFC38522.1 242 EKNTREKRMEDETVSRTEGEHMEKTINWTEVVKKETERQKNVSRTLKMRVLFKYYIGLFLGALAGIVFFLFEVAFL 317
                 5556678899999999999999999999999999999999999999999988885555555555555554444332 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 0.46
     DUF5305 114 aegilliilgllaliglvvlirriift 140
                 ae il++i +ll+ i++ ++ ++ + t
  EFC38522.1 466 AEKILIAISYLLIFIAIGLISYSAFPT 492
                 456788888888888888887776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1172  (0.065369); expected 358.6 (0.02)
Passed bias filter:                      574  (0.0320152); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.82u 0.35s 00:00:01.17 Elapsed: 00:00:00.54
# Mc/sec: 2800.95
//
Query:       EFC38523.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0094   16.4   0.1     0.0094   16.4   0.1    2.1  3  CYYR1     Cysteine and tyrosine-rich protein 1
  ------ inclusion threshold ------
      0.018   14.9   5.1        0.2   11.5   1.5    2.2  2  DarT      ssDNA thymidine ADP-ribosyltransferase, DarT


Domain annotation for each model (and alignments):
>> CYYR1  Cysteine and tyrosine-rich protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.5      0.52   4.6e+03      58      78 ..      17      36 ..       6      76 .. 0.61
   2 ?   -3.7   0.0       1.6   1.4e+04      25      37 ..     145     157 ..     143     172 .. 0.73
   3 !   16.4   0.1     1e-06    0.0094      33      81 ..     214     261 ..     176     263 .] 0.75

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.52
       CYYR1 58 givfgvvflmgvvagialcvc 78
                g +   +fl+ ++   ++c+ 
  EFC38523.1 17 GFIGMALFLISTIV-TFVCIN 36
                43333345544443.344443 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.6
       CYYR1  25 cedckeyccdgsp 37 
                 c+  +ey  +g++
  EFC38523.1 145 CRAMVEYVVNGTN 157
                 7778888888875 PP

  == domain 3  score: 16.4 bits;  conditional E-value: 1e-06
       CYYR1  33 cdgsppfccsyyayvgdvlsgtaiagivfgvvflmgvvagialcvcmcv 81 
                  +g + f    y+y+ + l g   a ivf v+f++  ++gi++   mc 
  EFC38523.1 214 SNGETLF-SNRYSYLYKNLLGWGAASIVFSVLFFFAFLTGIIIIAVMCN 261
                 3455555.467899999999****************************5 PP

>> DarT  ssDNA thymidine ADP-ribosyltransferase, DarT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   1.5   2.2e-05       0.2      60     124 ..     116     175 ..      82     187 .. 0.71
   2 ?    5.1   0.1     0.002        18      46      75 ..     194     223 ..     176     241 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2.2e-05
        DarT  60 vpfYfaprspmlyriergnhaeykgedivvLvidleilasgercvftdgnaaasg.tefrngledl 124
                 +pfYf+p+++ ly++++++ +        +L ++++ +  ++ +  t++  ++s+ +  + +l+++
  EFC38523.1 116 APFYFNPNNVSLYEYYSEDYP-----RNLWLDFNCRAM-VEYVVNGTNSELTNSFtSSNYPNLASF 175
                 7***************99954.....566777887777.556666666666666666666666655 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.002
        DarT  46 kevpippggtlgdYvpfYfaprspmlyrie 75 
                 ++v++ ++ ++gdY + Y +++  +l++++
  EFC38523.1 194 DKVQVSKQEQVGDYMNCYTNSNGETLFSNR 223
                 34555669**************99999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1428  (0.0796475); expected 358.6 (0.02)
Passed bias filter:                      597  (0.033298); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 1495.63
//
Query:       EFC38524.1  [L=196]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.5e-17   62.1   3.1    8.3e-17   61.9   3.1    1.0  1  Glyco_hydro_25  Glycosyl hydrolases family 25


Domain annotation for each model (and alignments):
>> Glyco_hydro_25  Glycosyl hydrolases family 25
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.9   3.1   4.6e-21   8.3e-17       2     155 ..      29     185 ..      28     196 .] 0.80

  Alignments for each domain:
  == domain 1  score: 61.9 bits;  conditional E-value: 4.6e-21
  Glyco_hydro_25   2 Dvssyqgdid...wqkvkasGvsfviiKaTeGtsyvdptfkeqvanaraaglk.vgaYhFarpvnsstakaeadyFlsnvq..kldastlplvlD 90 
                     D+s +qgd++   w+ +k+sG +f+ii+a  +t +v+p++++ +++a+aag+k v +Y+F +    ++a+a+ ++ ++ ++  +++ +++   lD
      EFC38524.1  29 DLSYFQGDVSqssWNCLKQSGREFAIIQAQLSTGRVNPYVANDINRAKAAGIKyVDIYIFPNIN--EDAAAQVQNTVNFIKsnGATFGQI--WLD 119
                     99*******9999**************************************99568******96..888888888888886324444444..6** PP

  Glyco_hydro_25  91 vE..ktssaekaaateeikkfldevkkqtGkkpviYtsksflknnllesqliaeyplWiaeyakkep 155
                     +E  +  +++ +++++ i++ ++   ++tG+ + iY+s s ++  +  s+++++ +lW a y+++ +
      EFC38524.1 120 IEgpQYWTNNCQTNVNFISRMVNAG-RATGYPVHIYSSHSQWQPITCGSTAFSNLQLWWAYYDNNAS 185
                     **74444555555666666666666.899**********9999985555555999*******98865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       602  (0.0335769); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.35s 00:00:00.91 Elapsed: 00:00:00.52
# Mc/sec: 1123.84
//
Query:       EFC38525.1  [L=316]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.035   13.6   0.3      0.035   13.6   0.3    1.5  2  Stevor           Subtelomeric Variable Open Reading frame
       0.14   12.0   0.7       0.25   11.2   0.7    1.3  1  Amastin          Amastin surface glycoprotein
       0.22   11.6   1.8       0.39   10.8   1.8    1.3  1  Phage_holin_3_6  Putative Actinobacterial Holin-X, holin supe
       0.22   11.4   1.7       0.32   10.9   1.7    1.2  1  DctQ             Tripartite ATP-independent periplasmic trans
        1.7    9.1   4.6       0.77   10.3   0.6    2.1  2  TraL             TraL protein


Domain annotation for each model (and alignments):
>> Stevor  Subtelomeric Variable Open Reading frame
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.3   9.9e-06     0.035     197     262 ..      82     149 ..      63     154 .. 0.80
   2 ?   -3.2   0.1       1.3   4.7e+03     107     136 ..     230     257 ..     226     266 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 9.9e-06
      Stevor 197 lnlfsesslesalk.aavsaaaasdlagtaasaassafepygiaalvllilavvliiLYiwly.rRRK 262
                 ++l+  + l ++l    ++a+++++ ++    +  s++ p g +a +ll++ v++i+L i +  +RRK
  EFC38525.1  82 FSLIAIAELIACLVlGVLMATCVKQPKQDNCPVYDSIMIPLGASAGILLVMGVLFILLSIRMIiQRRK 149
                 5555556666666656778888999999999999**************************87526777 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.3
      Stevor 107 gmytnddekssdskscectdinnakLaktk 136
                 ++    +++s+   s ++ + n+++La t 
  EFC38525.1 230 NIVAGTNNTSD--ASLQYYNHNESELAMTN 257
                 55555555665..77888888888888775 PP

>> Amastin  Amastin surface glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.7   6.9e-05      0.25      64     114 ..      78     143 ..      70     163 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6.9e-05
     Amastin  64 aaqafsiisilvlaaalllsvllllcc...............sslkwvclllnivsvvtllivwal 114
                 ++ +fs+i+i+ l+a l+l+vl++ c+                 l     +l +++v++ l +  +
  EFC38525.1  78 LGGVFSLIAIAELIACLVLGVLMATCVkqpkqdncpvydsimIPLGASAGILLVMGVLFILLSIRM 143
                 6889**********************9777777777777776455555555555555555555544 PP

>> Phage_holin_3_6  Putative Actinobacterial Holin-X, holin superfamily III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   1.8   0.00011      0.39      40      94 ..      76     153 ..      72     159 .. 0.53

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00011
  Phage_holin_3_6  40 lgaagvlallalllllvala......................lalaa....lwlaalivaavllvlagvlalvglkklkka 94 
                      l+++gv+ l+a++ l+++l+                      +   +    + ++ l+v++vl++l  + +++ ++k++++
       EFC38525.1  76 LILGGVFSLIAIAELIACLVlgvlmatcvkqpkqdncpvydsI---MiplgASAGILLVMGVLFILLSIRMIIQRRKMAAM 153
                      4455555555555555555411111122255555555555542...12334566667777777777777777777777664 PP

>> DctQ  Tripartite ATP-independent periplasmic transporters, DctQ component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   1.7   9.1e-05      0.32      67     129 ..      86     147 ..      75     150 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 9.1e-05
        DctQ  67 liadllallfaavliwagwlevaaalfeettpvlglplwwvylvlpigaallalvalarllrl 129
                 +ia l+a+l+++vl+ +++ ++ ++++  + +++ +pl+    +l+++++l++l +++ ++++
  EFC38525.1  86 AIAELIACLVLGVLMATCV-KQPKQDNCPVYDSIMIPLGASAGILLVMGVLFILLSIRMIIQR 147
                 678889999999*******.999999999*****************************99987 PP

>> TraL  TraL protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.6   0.00021      0.77      22      58 ..      75     111 ..      73     120 .. 0.89
   2 ?   -0.1   0.3      0.38   1.3e+03      26      48 ..     122     144 ..     113     156 .. 0.54

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00021
        TraL  22 lvillllvvgillgqfviglvlglllvlllrklkkgr 58 
                 l il++++  i++++++++lvlg+l+++++++ k+++
  EFC38525.1  75 LLILGGVFSLIAIAELIACLVLGVLMATCVKQPKQDN 111
                 568899999***********************99986 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.38
        TraL  26 lllvvgillgqfviglvlglllv 48 
                 l++  gill   v++++l++ ++
  EFC38525.1 122 LGASAGILLVMGVLFILLSIRMI 144
                 44445555555555555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1064  (0.0593452); expected 358.6 (0.02)
Passed bias filter:                      545  (0.0303977); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 1948.16
//
Query:       EFC38526.1  [L=1095]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.4e-67  219.8  12.6    2.6e-06   27.2   0.2   13.1 12  NHL           NHL repeat
    2.9e-12   46.7   4.6    2.8e-05   23.9   0.5    6.1  5  SGL           SMP-30/Gluconolactonase/LRE-like region
    2.2e-10   40.7  94.6    4.7e-05   23.7   7.5    6.7  7  EGF_2         EGF-like domain
      9e-09   35.2  31.2      0.064   13.3   3.2    8.3  7  SBBP          Beta-propeller repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   5.2e-07    0.0023       4      27 ..      57      80 ..      54      81 .. 0.84
   2 !   15.5   0.0   2.9e-06     0.013       2      27 ..     111     136 ..     110     137 .. 0.93
   3 !    7.6   0.0   0.00095       4.3       2      27 ..     167     192 ..     167     193 .. 0.94
   4 !   21.6   0.3   3.4e-08   0.00015       6      27 ..     227     248 ..     227     249 .. 0.96
   5 !    6.4   0.0    0.0022       9.9       3      22 ..     280     299 ..     279     301 .. 0.88
   6 !   10.8   0.0   8.9e-05       0.4      14      27 ..     345     358 ..     342     359 .. 0.91
   7 !   26.5   0.0   9.4e-10   4.2e-06       1      27 [.     387     413 ..     387     414 .. 0.93
   8 !   23.7   0.0   7.2e-09   3.2e-05       2      27 ..     445     470 ..     444     471 .. 0.94
   9 !   27.2   0.2   5.8e-10   2.6e-06       1      26 [.     500     525 ..     500     525 .. 0.96
  10 !   21.6   0.0   3.5e-08   0.00016       1      27 [.     555     581 ..     555     582 .. 0.96
  11 !   21.9   0.0   2.8e-08   0.00013       1      26 [.     611     635 ..     611     636 .. 0.92
  12 !   12.6   0.1   2.5e-05      0.11       3      27 ..     668     692 ..     667     693 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 5.2e-07
                EEEEEEETTTEEEEEECCCTEEEE CS
         NHL  4 PhGvavdsnGdiyVaDsenhrvqv 27
                P++ a+ ++G +++aDs+nhr+++
  EFC38526.1 57 PASSALGPDGSLFIADSNNHRIRQ 80
                5666889***************85 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 2.9e-06
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                  +P +v+v+s+G+++ +D++n+r+++
  EFC38526.1 111 KNPVSVVVNSMGEVLFSDNGNNRIRK 136
                 68**********************97 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.00095
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 nyP G++++s  +++ +D +n+r+++
  EFC38526.1 167 NYPYGLTLNSKEELLFTDVNNNRIRQ 192
                 6899********************85 PP

  == domain 4  score: 21.6 bits;  conditional E-value: 3.4e-08
                 EEEEETTTEEEEEECCCTEEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvqv 27 
                 Gvavd+ ++iy+aD++n+r+++
  EFC38526.1 227 GVAVDTKDNIYIADTNNNRIRK 248
                 9*******************86 PP

  == domain 5  score: 6.4 bits;  conditional E-value: 0.0022
                 SEEEEEEETTTEEEEEECCC CS
         NHL   3 yPhGvavdsnGdiyVaDsen 22 
                 +P Gvav+s G++y +Ds++
  EFC38526.1 280 SPYGVAVSSLGEVYFSDSNR 299
                 688***********999886 PP

  == domain 6  score: 10.8 bits;  conditional E-value: 8.9e-05
                 EEEEEECCCTEEEE CS
         NHL  14 diyVaDsenhrvqv 27 
                 d+y+aD +nhr+++
  EFC38526.1 345 DLYIADKGNHRIRK 358
                 79**********97 PP

  == domain 7  score: 26.5 bits;  conditional E-value: 9.4e-10
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 ++ P G a+ds G+iy+aD+ nhrv++
  EFC38526.1 387 LSKPKGAALDSLGNIYIADTSNHRVRK 413
                 678**********************97 PP

  == domain 8  score: 23.7 bits;  conditional E-value: 7.2e-09
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n P+G+a ds G+iy+aDs+n+r+++
  EFC38526.1 445 NKPTGIAFDSIGNIYIADSGNNRIRK 470
                 68**********************97 PP

  == domain 9  score: 27.2 bits;  conditional E-value: 5.8e-10
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P +v+vdsn+ +y++D++nhr++
  EFC38526.1 500 LNSPVSVTVDSNDLVYITDTYNHRIR 525
                 799*********************96 PP

  == domain 10  score: 21.6 bits;  conditional E-value: 3.5e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+++a ds+++ y+aD++n+r+++
  EFC38526.1 555 LNYPQSIAFDSSNNMYIADTYNNRIRK 581
                 79***********************86 PP

  == domain 11  score: 21.9 bits;  conditional E-value: 2.8e-08
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 + yP+G+a+ +++++++aDs+n+r++
  EFC38526.1 611 LKYPQGIAI-DGDELLIADSYNNRIR 635
                 569******.6*************97 PP

  == domain 12  score: 12.6 bits;  conditional E-value: 2.5e-05
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                 +P+Gv +  nG+i+V Ds n+r++v
  EFC38526.1 668 NPSGVILRRNGEIIVIDSDNSRLRV 692
                 788887779**************98 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.15   6.8e+02     186     218 ..      57      89 ..      45      98 .. 0.79
   2 !   23.9   0.5   6.1e-09   2.8e-05      10     216 ..     176     421 ..     169     428 .. 0.78
   3 !    7.5   0.0   0.00059       2.7     184     218 ..     445     479 ..     431     484 .. 0.85
   4 !    3.7   0.0    0.0085        38     147     218 ..     513     590 ..     506     597 .. 0.69
   5 !    5.2   0.0     0.003        13       4      77 ..     616     695 ..     613     711 .. 0.65

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.15
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 p ++a+  +G +++A  ++++++++ p+G++++
  EFC38526.1  57 PASSALGPDGSLFIADSNNHRIRQVFPNGTITT 89 
                 556778888899999999999999888888765 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 6.1e-09
         SGL  10 eegaLlwvDilgqrihrldpatgketv............ldtpe.....svGaiaprkdgrlvvasksglall.dlasgeletladeee.......... 80 
                  +++Ll++D+ ++ri ++ ++++  tv            +++ +     s G++++ +++++++a +++ ++   l +g++ t+a              
  EFC38526.1 176 SKEELLFTDVNNNRIRQVFNNGTIITVagsnsqgyngdnMKATSatlflSFGVAVD-TKDNIYIADTNNNRIRkVLLNGTIVTIAGTGTgdyygdggla 273
                 5789***********************77777777776633333567667777777.556666666555544433445556555555224555556444 PP

         SGL  81 dekpllrfNDgvvdpdGrlwfGtmgdeeakgeev.......galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsn 172
                    + +++  ++v++ G+++f + +  ++ ++++       ++ly ++ +  +++ l  l+ p  +++ + ++ lY+aD  +++i +++    ++  ++
  EFC38526.1 274 TLAKINSPYGVAVSSLGEVYFSDSNRIRKVSTNGtittfagTSLYGFTDN--TTVNLATLASPELMNFAKNTSDLYIADKGNHRIRKISNGFITTIAGQ 370
                 34456666689************998887777667888876666666666..7777889*******************************999999999 PP

         SGL 173 rrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpd.Gkl 216
                   + +++++ +      ++p G+a+D+ Gn+++A  ++++v++++   G++
  EFC38526.1 371 GSPSYCGENVDsrlsalSKPKGAALDSLGNIYIADTSNHRVRKISYLdGTI 421
                 9999999999999999977************************98654655 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.00059
         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                 ++p G+a D+ Gn+++A  g+++++++ ++G++++
  EFC38526.1 445 NKPTGIAFDSIGNIYIADSGNNRIRKILTNGTILT 479
                 4589***************************9876 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.0085
         SGL 147 tlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge......gepDGlavDaeGnvwvAvwgggkvvrfdpdGklie 218
                  +Y++D+ +++i  +  + + +++    v ++++         ++p ++a D+++n+++A   +++++++ ++G++i+
  EFC38526.1 513 LVYITDTYNHRIRLILPSGNISTVIGGSVGFNGDYLLpnntklNYPQSIAFDSSNNMYIADTYNNRIRKMFTNGTIIT 590
                 566666666666666555555555555544443333355556678999999999999999999999999999998876 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.003
         SGL   4 GpvwdeeegaLlwvDilgqrihrldpatgketv..............ldtpesvGaiaprkd.grlvvasksglalldlasgeletlad 77 
                 G+  d  +++Ll  D +++ri r+ ++++ +t               +       ++ + ++  ++++  +++++++d ++++l+++ +
  EFC38526.1 616 GIAID--GDELLIADSYNNRIRRVLSNGNITTItgtgdlgysedgttA-------SASKINNpSGVILRRNGEIIVIDSDNSRLRVIST 695
                 55555..799***************99999999666666643333331.......3333333456666666666666666655555554 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.9   2.6         4   1.8e+04      10      19 ..      40      47 ..      40      47 .. 0.73
   2 !    7.4   5.2    0.0013       5.8       6      32 .]     708     733 ..     703     733 .. 0.88
   3 !   23.7   7.5     1e-08   4.7e-05       5      32 .]     746     772 ..     742     772 .. 0.91
   4 !   19.6   9.7   1.9e-07   0.00086       5      32 .]     785     811 ..     781     811 .. 0.88
   5 !   18.4  11.1   4.6e-07    0.0021       4      32 .]     822     850 ..     816     850 .. 0.86
   6 !   16.7   6.3   1.6e-06    0.0072       5      32 .]     998    1029 ..     992    1029 .. 0.91
   7 ?   -4.7   4.6         4   1.8e+04      23      32 .]    1032    1041 ..    1031    1048 .. 0.78

  Alignments for each domain:
  == domain 1  score: -5.9 bits;  conditional E-value: 4
       EGF_2 10 ghGtCvnqcG 19
                g+G+C+  +G
  EFC38526.1 40 GGGVCD--GG 47
                679998..55 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0013
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g G+C ++  +CdC + y G  C
  EFC38526.1 708 NVCNGLGVCFAPD-VCDCGDLYGGQFC 733
                 78********999.****999999998 PP

  == domain 3  score: 23.7 bits;  conditional E-value: 1e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ +G+C++++  C C++g++G++C
  EFC38526.1 746 SKVCSSRGVCNSPN-TCICNPGFYGNNC 772
                 678********999.9************ PP

  == domain 4  score: 19.6 bits;  conditional E-value: 1.9e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C ++   C+C++g++G +C
  EFC38526.1 785 SSVCSGNGNCTATD-SCQCFNGWFGFDC 811
                 689*******9777.7************ PP

  == domain 5  score: 18.4 bits;  conditional E-value: 4.6e-07
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+g+G C +  ++CdC++g+ G +C
  EFC38526.1 822 NdSSVCSGNGNCSTV-NKCDCQFGWKGLDC 850
                 35889*******944.5************9 PP

  == domain 6  score: 16.7 bits;  conditional E-value: 1.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdC.....dsgyqGktC 32  
                  +  CgghG C++q+  C+C     d  ++G +C
  EFC38526.1  998 SAVCGGHGLCISQN-ICQCkansaDGYWTGSNC 1029
                  678********999.*****9999999****99 PP

  == domain 7  score: -4.7 bits;  conditional E-value: 4
       EGF_2   23 CdsgyqGktC 32  
                  C+++y G+ C
  EFC38526.1 1032 CQANYCGDGC 1041
                  7888888877 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   1.4   0.00093       4.2      17      29 ..     227     239 ..     225     246 .. 0.88
   2 ?    1.4   0.4     0.074   3.3e+02       8      27 ..     273     293 ..     258     294 .. 0.83
   3 !   10.3   0.0   0.00012      0.54      14      34 ..     389     409 ..     382     410 .. 0.81
   4 !   13.3   3.2   1.4e-05     0.064       8      29 ..     439     461 ..     423     468 .. 0.85
   5 ?    2.2   0.5     0.041   1.8e+02      10      29 ..     497     517 ..     485     517 .. 0.81
   6 !    9.5   0.0   0.00021      0.95      13      29 ..     555     572 ..     548     572 .. 0.85
   7 !    4.3   0.1    0.0091        41       8      22 ..     606     621 ..     597     623 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00093
        SBBP  17 gIavDsnGNiYvt 29 
                 g+avD+  NiY++
  EFC38526.1 227 GVAVDTKDNIYIA 239
                 89*********97 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.074
        SBBP   8 gpgast.ygngIavDsnGNiY 27 
                 ++ a++ +++g+av s+G +Y
  EFC38526.1 273 ATLAKInSPYGVAVSSLGEVY 293
                 66777889**********988 PP

  == domain 3  score: 10.3 bits;  conditional E-value: 0.00012
        SBBP  14 ygngIavDsnGNiYvtGsTng 34 
                 +++g a Ds+GNiY++ ++n+
  EFC38526.1 389 KPKGAALDSLGNIYIADTSNH 409
                 5777799********988876 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 1.4e-05
        SBBP   8 gpgast.ygngIavDsnGNiYvt 29 
                 +++a++ +++gIa+Ds GNiY++
  EFC38526.1 439 ATSAQVnKPTGIAFDSIGNIYIA 461
                 67888989**************8 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.041
        SBBP  10 gast.ygngIavDsnGNiYvt 29 
                 +a++ ++ +++vDsn  +Y+t
  EFC38526.1 497 NAKLnSPVSVTVDSNDLVYIT 517
                 56666789*******999998 PP

  == domain 6  score: 9.5 bits;  conditional E-value: 0.00021
        SBBP  13 t.ygngIavDsnGNiYvt 29 
                 + y+++Ia+Ds+ N Y++
  EFC38526.1 555 LnYPQSIAFDSSNNMYIA 572
                 449*************97 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.0091
        SBBP   8 gpgast.ygngIavDs 22 
                 +++a++ y++gIa+D 
  EFC38526.1 606 ATNAQLkYPQGIAIDG 621
                 7888999********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1095 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1563  (0.0871772); expected 358.6 (0.02)
Passed bias filter:                      257  (0.0143343); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.95u 0.36s 00:00:01.31 Elapsed: 00:00:00.51
# Mc/sec: 6397.79
//
Query:       EFC38527.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.057   13.5   0.0      0.099   12.7   0.0    1.4  1  RcsF      RcsF lipoprotein


Domain annotation for each model (and alignments):
>> RcsF  RcsF lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   5.5e-06     0.099      78     109 ..      83     114 ..      68     115 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.5e-06
        RcsF  78 kanavLlhqCeivsgvagCyqqaiCeGsalkv 109
                 +++  L   C+i s  +g  + ++C+Gs l+v
  EFC38527.1  83 QGDVLLSNLCAIKSEFRGGDKVVVCKGSSLNV 114
                 566677788*********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       268  (0.0149478); expected 358.6 (0.02)
Passed bias filter:                      221  (0.0123264); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.26s 00:00:00.71 Elapsed: 00:00:00.44
# Mc/sec: 1159.57
//
Query:       EFC38528.1  [L=587]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.7    6.2   9.3        4.1    5.7   9.3    1.1  1  Menin     Menin


Domain annotation for each model (and alignments):
>> Menin  Menin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   9.3   0.00023       4.1     536     600 ..      62     124 ..      53     140 .. 0.66

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.00023
       Menin 536 erreannnnnsksnsekeadkkasttsnggeasstpsseseaavespsehkeakleeksqelasa 600
                  +++a nnnn+k n++++ ++k+ +  + +++ss  ++  +++v++  + k+a++e+++q   s+
  EFC38528.1  62 ASSKALNNNNIKINNNNNNNTKSKALKRNNSSSS--NNVNNKNVNTTMNAKDARKEKRRQLFKSK 124
                 4455667777777777777776666665555555..44455667777778888888877555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (587 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1670  (0.0931452); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.28s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 3592.59
//
Query:       EFC38529.1  [L=1255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-12   47.3  40.2     0.0001   22.6   8.6    3.5  3  EGF_2     EGF-like domain
    4.6e-07   29.8   1.2    2.9e-06   27.2   0.1    2.8  4  UPF0669   Putative cytokine, C6ORF120


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   8.8   7.6e-07    0.0068       5      32 .]     892     918 ..     889     918 .. 0.87
   2 !   22.6   8.6   1.1e-08    0.0001       5      32 .]     931     957 ..     923     957 .. 0.90
   3 !   19.9   6.8   7.8e-08    0.0007       6      32 .]     971     996 ..     966     996 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 7.6e-07
       EGF_2   5 deiCgghGtCvnqc.GqCdCdsgyqGktC 32 
                 ++ C+g G C+  + ++C+C  gy G+ C
  EFC38529.1 892 NNVCSGKGNCI--GyNECECLEGYEGDEC 918
                 799********..6348************ PP

  == domain 2  score: 22.6 bits;  conditional E-value: 1.1e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G Cv+++ +C+C+ gy+G++C
  EFC38529.1 931 KTVCSSRGNCVSPN-KCECSGGYFGDSC 957
                 788********999.************* PP

  == domain 3  score: 19.9 bits;  conditional E-value: 7.8e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g+G C ++  +C+C+ gy+G+ C
  EFC38529.1 971 RVCSGNGFCSSLD-KCQCKYGYFGAEC 996
                 57********999.************* PP

>> UPF0669  Putative cytokine, C6ORF120
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   0.1   3.3e-10   2.9e-06      42     115 ..     157     236 ..     149     247 .. 0.82
   2 ?   -3.4   0.0      0.79   7.1e+03      33      76 ..     355     403 ..     346     413 .. 0.57
   3 ?   -3.8   0.0       1.1   9.4e+03      59      87 ..     493     521 ..     479     526 .. 0.81
   4 ?   -1.6   0.0      0.22     2e+03      65     132 ..     711     777 ..     697     791 .. 0.71

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 3.3e-10
     UPF0669  42 qigagnysylrlnheg....kiilrlqslkgdadlyvsdstlkpsfdeyelqsvtcgadvvsipahfrrp..vgigiygh 115
                 q+    ysy+++   g    k+ + + +  gd+dlyvs  +  p+  +y+  s + g d v+ip + + p    ig+yg+
  EFC38529.1 157 QVERNGYSYFKVKVTGqlptKLYISIGTQEGDSDLYVSGISQFPTSTDYDYASRSYGPDSVTIPVEENSPreYWIGVYGY 236
                 566678999999999922223456778899*********************************98876552278****97 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.79
     UPF0669  33 wvllh...vvqgqigagnysylrlnheg..kiilrlqslkgdadlyvsd 76 
                 +vll     v+g + a +  y + n++   k  l l  + g   l++s 
  EFC38529.1 355 YVLLQedvAVNGTVAANQLNYYQHNKKDmlKSSLTLTVFFGSVKLFLSF 403
                 4444323247788888877777777655112345555555555555555 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 1.1
     UPF0669  59 iilrlqslkgdadlyvsdstlkpsfdeye 87 
                 i++ + +  g  +lyv  +   ps  +y+
  EFC38529.1 493 IMFFISTSVGSVELYVNTKNTFPSPRDYN 521
                 5556666779999***9999999988887 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 0.22
     UPF0669  65 slkgdadlyvsdstlkps..fdeyelqsvtcgadvvsipahfrrpvgigiyghpshlesefelkvyydrt 132
                  + g + +yvs+     +    +++++  t   +v++++++      ig+yg    + s f+l  + d +
  EFC38529.1 711 NITGSTIMYVSNDCQPANetHYNWKVDPETQYGQVLMLSNQQVGCYYIGVYGL---VASTFKLSAFLDDA 777
                 66788889999876544400445566777777778888888888888999996...45777777777755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       713  (0.039768); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.90u 0.29s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 7187.13
//
Query:       EFC38530.1  [L=541]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.43   11.1   6.4        2.6    8.6   0.2    3.2  2  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   1.5    0.0067   1.2e+02      20      43 ..     305     326 ..     283     331 .. 0.62
   2 ?    8.6   0.2   0.00015       2.6      18      33 ..     407     422 ..     398     431 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.0067
                 H.H-TT--EEE-.-S-----GGGGX CS
       LRR_4  20 e.klpnLkeLdLsgNnlitdldeLk 43 
                 + +l  L  L+L+++   t ld+L+
  EFC38530.1 305 AfSLHELILLNLNNF---TELDTLS 326
                 245888888888444...3444443 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00015
                 -HHH-TT--EEE-.-S CS
       LRR_4  18 lleklpnLkeLdLsgN 33 
                  l++lpnL++L +s N
  EFC38530.1 407 YLKQLPNLETLEISKN 422
                 4778*********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (541 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 3236.33
//
Query:       EFC38531.1  [L=275]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.6e-21   76.4   4.2    4.2e-21   76.1   4.2    1.1  1  DUF262    Protein of unknown function DUF262


Domain annotation for each model (and alignments):
>> DUF262  Protein of unknown function DUF262
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.1   4.2   2.4e-25   4.2e-21      11     221 .]      18     263 ..       8     263 .. 0.70

  Alignments for each domain:
  == domain 1  score: 76.1 bits;  conditional E-value: 2.4e-25
      DUF262  11 g....lriPdfQRpyvWeeeqveeLiedlla...lkgyplGsivlwskaadsageleviDGQQRltTltlllaa....t.....keesekriknleaei 93 
                 g    ++iP++QR+y W+ + v++L++dl+    + g+ +G +++    +++      iDGQQRltTl + ++a    +     +   ek ++++   i
  EFC38531.1  18 GkssqIQIPIYQRKYCWNSKIVKQLYNDLVFngtSFGHHIGKLFF----QKKLASRVCIDGQQRLTTLLIGICAlrdaAlelvdS---EKILDEIHSYI 109
                 344449***********************889*99**********....77789999*****************76651553343...33333333333 PP

      DUF262  94 ek.......ekeeededrlkrreresdkellqkllrseklsleekeelaelnsltkkdlakeekrneeknlikayevieeilksa.............l 172
                 +         +ee+ +++ k+ +  +  + +++l+ s +++ ++ e l  +++ + + l   +++n  ++ +  y++++++l ++              
  EFC38531.1 110 FVksvdlkkLQEEYLSSEDKYAKASEIAKNVSRLIPSHDDRVSNIEILIGFKGDQTNLL---QNSNMHNTRQIFYKIFKSQLVKQqvnslaivkssliP 205
                 33344555566667777777777778888888888888888888777777777666666...3355555555555555555555589888887776442 PP

      DUF262 173 lsalktklslieielese.........ddedqayeiFerlNsrGvpLtasellkalll 221
                 + ++  k+ +ie+e +++          d  + ++i   + + G  L+ s+l+k++ll
  EFC38531.1 206 ILTINGKFVIIEYEESEInaqecfgerYDVGKSNQILFYIKTPGIDLSYSDLIKNHLL 263
                 222225555555555544666677777777778999999****************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       586  (0.0326845); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1552.70
//
Query:       EFC38532.1  [L=798]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.066   13.3   0.0        1.9    8.6   0.0    2.8  3  G8        G8 domain


Domain annotation for each model (and alignments):
>> G8  G8 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0     0.033   5.9e+02      24      48 ..     202     226 ..     197     241 .. 0.81
   2 ?   -1.7   0.0      0.17     3e+03      78     117 ..     282     327 ..     268     330 .. 0.77
   3 ?    8.6   0.0    0.0001       1.9      11      74 ..     567     634 ..     559     680 .. 0.65

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.033
          G8  24 ldvsspklrsllveGtLifsddksd 48 
                 l++s+ + + l+v+G+Li +++k+ 
  EFC38532.1 202 LNKSPSNTQFLTVDGSLITPNKKKH 226
                 567889999*********9777533 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.17
          G8  78 tItLyG......teewsstelpdlgaKvlavsngGtlelhGqprkk 117
                 +++++       tee +++e++ ++ Kvl+  n+ +++  G + ++
  EFC38532.1 282 ELSFHSssnerhTEEGNPAENCLINDKVLGRENRSQIDQEGDKNNQ 327
                 5666666666667888999999999****99999999988877665 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0001
          G8  11 gdnvvIpagktvlldvsspk......lrsllve..GtLifsddksdielnaeyilvqggGkleiGteeepfk 74 
                 +++vvIp++k+v++d s+        ++ l+v+   +L f  + s+++++ + i  +++ ++++  e++ f 
  EFC38532.1 567 QQKVVIPKKKNVVYDPSNYFyllvagVNFLVVQtiRSLFF--E-SKTDFECKSIKFNKE-EFKVKVESCSFM 634
                 789***********95444334444445555554444555..2.677777777777765.777777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (798 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1055  (0.0588432); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.74u 0.29s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 4622.69
//
Query:       EFC38533.1  [L=387]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-41  142.1   0.0    2.1e-41  141.6   0.0    1.2  1  RimK             RimK-like ATP-grasp domain
    9.9e-14   51.2   2.6    6.5e-06   25.6   0.1    3.4  4  ATPgrasp_ST      Sugar-transfer associated ATP-grasp
    1.5e-10   40.7   0.0    2.5e-10   40.0   0.0    1.3  1  GSH-S_ATP        Prokaryotic glutathione synthetase, ATP-gras
    1.4e-08   34.3   0.2    0.00017   20.9   0.2    3.0  1  ATPgrasp_YheCD   YheC/D like ATP-grasp
    2.6e-07   30.1   0.1    0.00079   18.6   0.1    2.3  2  TTL              Tubulin-tyrosine ligase family
    3.9e-07   30.3   0.1    7.7e-07   29.3   0.1    1.5  1  ATP-grasp_3      ATP-grasp domain
      6e-07   29.8   0.0    1.4e-06   28.6   0.0    1.7  1  Rimk_N           RimK PreATP-grasp domain
    1.3e-05   24.8   0.0      2e-05   24.2   0.0    1.2  1  Synapsin_C       Synapsin, ATP binding domain
    0.00035   20.2   0.0    0.00054   19.6   0.0    1.3  1  ATP-grasp        ATP-grasp domain
  ------ inclusion threshold ------
      0.012   15.2   0.0      0.064   12.8   0.0    2.0  1  Dala_Dala_lig_C  D-ala D-ala ligase C-terminus


Domain annotation for each model (and alignments):
>> RimK  RimK-like ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  141.6   0.0   1.2e-44   2.1e-41       2     184 ..     185     372 ..     184     376 .. 0.92

  Alignments for each domain:
  == domain 1  score: 141.6 bits;  conditional E-value: 1.2e-44
                 H-HHHHHHHHHHTT-----EEEESS-S-HHHHHHTT-.-SSEEEEE-TTTT--EEEEE-SHHHHHHHHHH..GGG--EEEEE--SS-SEEEEEEEETTE CS
        RimK   2 rdKlkslklLakakikvpntalardeedaekliekiklrfPvvvKsvegsqGikvvlakkeqklkqvlea..lkeailvqeyieeaenediRvlvvdde 98 
                 +dKl +++ La+++i +p+t  a  +    + ie+   + P v+K+ +gsqG +++l k++++l+++ e   + ++ ++qe+i ++ ++d+R++v++d 
  EFC38533.1 185 KDKLVTMQTLARKRISIPKTIAATFPLTRFEWIEQKLGGYPKVLKKTNGSQGKGIILIKDRNQLQDLNEIisTSNNWILQEFISNSSGKDLRIIVMGDM 283
                 79********************************98779**********************999988665668888899******************** PP

                 EEEEEEEE--SSS----TTTT-EEEE----HHHHHHHHHHHHHCT-SEEEEE.EEEETTEEEEEEEESS--SHHHHHHH..T--HHHHH CS
        RimK  99 vvaalrrvskeGdFRsnlhrGgvaeklqlseeekelAikaakamelvvaGvD.llrakrgllvlEvnsspglekiektl..gidiakkl 184
                 vv+++ r+s +G+F++n h+G+  ek+ ++ee+++lA   +k  +l++ GvD ll+ ++ + ++E+nsspg e++e+    +i+i  + 
  EFC38533.1 284 VVGSMMRKSTNGNFKANFHQGALCEKFPMNEELERLARLTTKECHLDISGVDiLLDHENVYKICEINSSPGCEGFEQAHcgEINIGRET 372
                 ****************************************************7788888899*************98752246666655 PP

>> ATPgrasp_ST  Sugar-transfer associated ATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       2.4   4.2e+03     107     132 ..     114     139 ..     110     144 .. 0.77
   2 !   25.6   0.1   3.6e-09   6.5e-06       9      84 ..     174     247 ..     167     259 .. 0.89
   3 !   16.7   0.2   1.8e-06    0.0033     137     183 ..     268     307 ..     251     314 .. 0.81
   4 !    7.2   0.0    0.0014       2.6     233     273 ..     320     360 ..     309     366 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.4
  ATPgrasp_ST 107 ilagLyslggkpdvalveelikqdpe 132
                    +gL+s+   +++ l ++ ++ d +
   EFC38533.1 114 KVTGLFSVCADSETDLLQNQVEYDGK 139
                  56799999999999999998887755 PP

  == domain 2  score: 25.6 bits;  conditional E-value: 3.6e-09
  ATPgrasp_ST   9 kyNpraefplvddKlkfkelalraglkvpkllgvikeqaeiseleafvkeleegvviKpakgsgGkGilvitered 84 
                   +N+ + +++ +dKl++ + + r+ +++pk+++       ++ +e+ + ++++  v+K ++gs GkGi+ i++r++
   EFC38533.1 174 VLNSSKGMEISKDKLVTMQTLARKRISIPKTIAATFPLTRFEWIEQKLGGYPK--VLKKTNGSQGKGIILIKDRNQ 247
                  57999999*************************99999*************77..9999************88665 PP

  == domain 3  score: 16.7 bits;  conditional E-value: 1.8e-06
  ATPgrasp_ST 137 spesvntiRvitflkdkkvevmlamlRlgtkaskvDgkaNlhqGgvg 183
                  s +s  ++R+i++    +  v+  m+R +t+++    kaN+hqG+++
   EFC38533.1 268 SNSSGKDLRIIVM----GDMVVGSMMRKSTNGN---FKANFHQGALC 307
                  456669*******....5556669*********...689******97 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0014
  ATPgrasp_ST 233 akaaeklpglgylGwDivldeekgplllElNarpglaivqi 273
                  a++ +k + l + G+Di ld+e+   + E+N  pg + ++ 
   EFC38533.1 320 ARLTTKECHLDISGVDILLDHENVYKICEINSSPGCEGFEQ 360
                  3455558999*************999********9988765 PP

>> GSH-S_ATP  Prokaryotic glutathione synthetase, ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.0   0.0   1.4e-13   2.5e-10      35     165 ..     227     354 ..     195     358 .. 0.79

  Alignments for each domain:
  == domain 1  score: 40.0 bits;  conditional E-value: 1.4e-13
                 EEEESS--TTTT-EEE-TT-TTHHHHHHHHTTTTTS-EEEEE--GGGGG-EEEEEEETTEE-SEEEEEE--SS-S---GGGTSCEEEEE--HHHHHHHH CS
   GSH-S_ATP  35 ilKPldgkgGegvfrvkksdpnlksilellteegkepviaqrylpeikeGDkRillvdGepigyalaRvpaegevRsnlaaggraeatelterdreiae 133
                 +lK  +g+ G+g++ +k+ +++l+ + e+++++++  +i+q+++ + +  D Ri+++    +g ++ R +++g++++n++ g+  e+ +++e+ +++a+
  EFC38533.1 227 VLKKTNGSQGKGIILIKD-RNQLQDLNEIISTSNN--WILQEFISNSSGKDLRIIVMGDMVVG-SMMRKSTNGNFKANFHQGALCEKFPMNEELERLAR 321
                 79999*********9987.7789999999988766..9******************9999999.****************************9999998 PP

                 HHHHHHHHTT--EEEEEEETT.....EEEEEE-SS-- CS
   GSH-S_ATP 134 elapkLkekGllfvGlDvigd.....kltEinvtsPt 165
                   ++   e  l + G+D++ d     k+ Ein  sP+
  EFC38533.1 322 LTTK---ECHLDISGVDILLDhenvyKICEIN-SSPG 354
                 6554...4456677888875523333466666.4555 PP

>> ATPgrasp_YheCD  YheC/D like ATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.2   9.5e-08   0.00017      11     237 ..     186     362 ..     182     377 .. 0.76

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 9.5e-08
  ATPgrasp_YheCD  11 nKwevyelLskdp.elrpyLPetellesledleemlekyksvylKpanGskGkgilriekeekellllsrekkkkkkkrlaslselesllkkllk 104
                     +K  ++++L++++ ++ + + +t +l+++e +e+ l  y++v lK +nGs+Gkgi+ i+                 +++   l++l+++++    
      EFC38533.1 186 DKLVTMQTLARKRiSIPKTIAATFPLTRFEWIEQKLGGYPKV-LKKTNGSQGKGIILIKD----------------RNQ---LQDLNEIIS---T 257
                     7888888888776367788999999****************8.7999************9................233...444555554...3 PP

  ATPgrasp_YheCD 105 kkrylvQqgidlatidgrpfDfRvlvqKngkgkWevtgiaaRiagkgsittnlsrGGtalpleellkkafgeekaekileeleelalelaealee 199
                     +++ ++Q+ i+ ++      D+R++v  +      v+g ++R + +g++ +n+++G+   +                ++eele+la  + +    
      EFC38533.1 258 SNNWILQEFISNSS----GKDLRIIVMGD-----MVVGSMMRKSTNGNFKANFHQGALCEK--------------FPMNEELERLARLTTKECH- 328
                     44688999998766....55999999854.....478888999999999999999864433..............3466778887766655544. PP

  ATPgrasp_YheCD 200 sfgrlgElGlDlgidkegkvWllEvNskpgrsifkeag 237
                         l   G+D+ +d+e+ + + E+Ns pg++ f++a+
      EFC38533.1 329 ----LDISGVDILLDHENVYKICEINSSPGCEGFEQAH 362
                     ....5666999999999999999999999999999875 PP

>> TTL  Tubulin-tyrosine ligase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.1   4.4e-07   0.00079      69     111 ..     226     269 ..     170     270 .. 0.80
   2 !    9.1   0.0   0.00035      0.62     237     264 ..     329     356 ..     306     365 .. 0.86

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 4.4e-07
                 ---SS---XX------BSSTHHHHHH.HH..SSS-EEEEB--SS CS
         TTL  69 wIvKpsasarGkgirvfnkledikki.vsqsqkeplvvqkYier 111
                  ++K++++++Gkgi+++++ ++++++ + +s++++++ q++i++
  EFC38533.1 226 KVLKKTNGSQGKGIILIKDRNQLQDLnEIISTSNNWILQEFISN 269
                 489**********************966678999********86 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00035
                 XXXXXXXXXXXXXXXXXXXXXXXXX..X CS
         TTL 237 felyGvDilidenlkpwLlEvNasPdlk 264
                  ++ GvDil+d +   ++ E+N+sP ++
  EFC38533.1 329 LDISGVDILLDHENVYKICEINSSPGCE 356
                 5788*********************875 PP

>> ATP-grasp_3  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.1   4.3e-10   7.7e-07       2     156 ..     185     351 ..     184     355 .. 0.79

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 4.3e-10
                  TSHHHHHHHHTTT.S---.............-EESS--SSSEEEEESS-------B--SS--TTE............EEEE---...SEEEEEEEEE. CS
  ATP-grasp_3   2 sdKlktykkLkeagvkvP.........tkleaeeleeeekklvvKprdGaggesvrvveekeeaeaaieeve.....lvqefie...GkplSvsllsd 82 
                  +dKl t++ L ++ + +P         t+ e  e +   ++ v+K+ +G+ g+++ +++++++++   e ++     ++qefi+   Gk+l + +++ 
   EFC38533.1 185 KDKLVTMQTLARKRISIPktiaatfplTRFEWIEQKLGGYPKVLKKTNGSQGKGIILIKDRNQLQDLNEIIStsnnwILQEFISnssGKDLRIIVMG- 281
                  69****************77777665555555555555***********************9988444433367789******73335555555555. PP

                  SSSEEEEEEEEEEEET....TEEEEEEES----HHHHHHHHHHHHHTTSTT--EEEEEEEEESS.SEE.EEEEES CS
  ATP-grasp_3  83 gekvlvlavnrqliekaekefvyaGnvtpietelkeevvelaeevvekleglaGyvGvDlvlkdeepy.viEvNP 156
                    +++v ++ r+  + + k +  +G + +    ++ee+++la+ ++++    + + GvD++l  e+ y + E+N+
   EFC38533.1 282 --DMVVGSMMRKSTNGNFKANFHQGALCEKF-PMNEELERLARLTTKEC--HLDISGVDILLDHENVYkICEINS 351
                  ..56777788888877777799999998765.89*************99..6789********98877588**97 PP

>> Rimk_N  RimK PreATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.6   0.0   7.9e-10   1.4e-06       1      93 [.      82     180 ..      82     181 .. 0.83

  Alignments for each domain:
  == domain 1  score: 28.6 bits;  conditional E-value: 7.9e-10
      Rimk_N   1 mkiaiLsrnpel.ystrrLveaaekrghevevldplrcylkieae....kpevyykgekleefdavipRigasitfygtavlrqFemm.gvfvlneseA 93 
                 ++++i+s+n+el y+ rr++e++ ++g+ v    +  +++  ++e    +++v y+g+ +e  +++i R ga+it+  +a+lr +e+  ++ vln+s++
  EFC38533.1  82 LRVWIISTNQELnYTRRRIIEEGWRAGVLVSSKVTGLFSVCADSEtdllQNQVEYDGKIVELPNVIINRCGAKITYCEMALLRFLESFeQCLVLNSSKG 180
                 699********98999***********9887666666655554442233789**********************************9725678888875 PP

>> Synapsin_C  Synapsin, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   0.0   1.1e-08     2e-05      49     156 ..     222     336 ..     198     352 .. 0.80

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 1.1e-08
  Synapsin_C  49 ptfpvvvklghahagmgkvkvenqydyqdiasvvalaktyataeafid.skydirvqkigsny.kaymrtsisgnwkantg.samleqvamsery.... 140
                   +p v+k      g g + ++++ + qd+  +++ ++ +   e + + s  d+r+  +g+    + mr s  gn+kan    a+ e+  m+e      
  EFC38533.1 222 GGYPKVLKKTNGSQGKGIILIKDRNQLQDLNEIISTSNNWILQEFISNsSGKDLRIIVMGDMVvGSMMRKSTNGNFKANFHqGALCEKFPMNEELerla 320
                 57999***********************************998876652568********97626799***********7526899***9998642112 PP

  Synapsin_C 141 klwvdscsemfggldi 156
                 +l    c   + g+di
  EFC38533.1 321 RLTTKECHLDISGVDI 336
                 4555555555555555 PP

>> ATP-grasp  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0     3e-07   0.00054      23      73 ..     217     268 ..     195     321 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 3e-07
                 HHHHH.-SCEEEEESSS-CTTTTEEEECTCCGHHCHHHHC.GTTCEEEEE--- CS
   ATP-grasp  23 aaeel.glpvvvKarrlgydGkGqsvvrseedleqaleal.keekvivEefvp 73 
                 + ++l g+p v+K ++ g+ GkG  +++++++l+++ e + +++++i+ ef++
  EFC38533.1 217 IEQKLgGYPKVLK-KTNGSQGKGIILIKDRNQLQDLNEIIsTSNNWILQEFIS 268
                 45666589*****.9***********************9988999******97 PP

>> Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   3.6e-05     0.064      30     177 ..     216     354 ..     203     359 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.6e-05
                      HHHHHC.-SSEEEEESSSSTTTTEEEESSGGGHHHHHHHHHTT-SCEEEEE--...ESEEEEEEEEETSSCEEEEEEEEE-SSSSS-HHHHHC. CS
  Dala_Dala_lig_C  30 kveeel.gypvfVKpareGSSvGvskveseeelkeaieeafkydekvlvEeai...egreievavlgneklevsevgeivvkkgfydyeakysd 119
                       +e++l gyp + K  +     G+  ++ +++l++  e     ++ +l E +i   +g+++ + v+g  ++ v ++ +  +++   +++a + +
       EFC38533.1 216 WIEQKLgGYPKVLKKTNGSQGKGIILIKDRNQLQDLNEIISTSNNWILQE-FIsnsSGKDLRIIVMG--DMVVGSMMRKSTNG---NFKANFHQ 303
                      5666663699999999988899***********99665555555555555.55466899******99..66666666655555...56888976 PP

                      TT-EEESS----HHHHHHHHHHHHHHHHHTT--SEEEEEEEEETTTEEEEEEEESS-- CS
  Dala_Dala_lig_C 120 dkaqlevpaklekeveekiqelalkaykaldlrGlaRvDfflteegeivlnEvNtlPG 177
                       +   ++p + e    e++  l  k    ld   ++ vD++l++e+   + E+N  PG
       EFC38533.1 304 GALCEKFPMNEEL---ERLARLTTKEC-HLD---ISGVDILLDHENVYKICEINSSPG 354
                      6655566654333...33333333332.244...5559*******************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (387 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.44
# Mc/sec: 2639.71
//
Query:       EFC38534.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00015   21.3   1.5    0.00021   20.8   0.3    1.6  2  SBP_bac_3  Bacterial extracellular solute-binding proteins, f


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.05     9e+02     148     163 ..      32      47 ..      13      70 .. 0.59
   2 !   20.8   0.3   1.1e-08   0.00021      99     181 ..     109     188 ..      53     194 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.05
                 HHTTSSSEEEEEHHHH CS
                 xxxxxxxxxxxxxxxx RF
   SBP_bac_3 148 Lkngrvdavvadspvl 163
                   ++  da+v d ++ 
  EFC38534.1  32 AVSDALDAAVQDLTTD 47 
                 2333334444333332 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 1.1e-08
                 TCCHSSCGCG..TTSEEEEETTSHHHHHHHHHHHCTSEEEEESSHHHHHHHHHTTSSSEEEEEHHHHHHHHHHCCGCCEEEEECG CS
                 xxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3  99 issiksladL..kgkkvgvqagstaeellkeelkkgaeivefdtleealqaLkngrvdavvadspvlaylvkknpdkkvvlveep 181
                 +++i    +L   g kvg+  g+++++++k el   a+ v ++  +  ++++kn+ v a+v+d ++  ++++++ ++ +++ ++p
  EFC38534.1 109 FNDIY---QLnqTGIKVGAYDGTNYATFIKTELT-AATYVKYAAVNLQYTDVKNNAVHAIVGDAIAYFDWANRQMNAAIIM-AAP 188
                 33444...55224559**************9876.899999********************************99999988.555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       794  (0.0442858); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1256.80
//
Query:       EFC38535.1  [L=1109]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.2e-31  109.1   3.8    2.7e-07   31.1   0.1    6.5  6  RCC1          Regulator of chromosome condensation (RCC1) rep
    7.3e-20   70.3  21.4      5e-06   26.2   0.4    6.6  6  RCC1_2        Regulator of chromosome condensation (RCC1) rep
    4.5e-10   39.3   5.7    0.00017   21.4   0.4    4.9  4  Kelch_5       Kelch motif
    0.00019   21.3   0.0    0.00047   20.0   0.0    1.6  1  Fibrinogen_C  Fibrinogen beta and gamma chains, C-terminal gl
  ------ inclusion threshold ------
      0.048   14.0  11.8       0.29   11.5   0.0    5.2  6  Kelch_6       Kelch motif
       0.13   12.4   0.1       0.22   11.7   0.1    1.3  1  RloB          RloB-like protein
       0.17   11.8   1.1       0.29   11.2   0.0    1.9  2  Ribosomal_S5  Ribosomal protein S5, N-terminal domain


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.9   0.0   1.6e-07   0.00042       4      50 .]     244     287 ..     243     287 .. 0.92
   2 !   31.1   0.1     1e-10   2.7e-07       4      50 .]     292     337 ..     291     337 .. 0.89
   3 !   16.2   0.1   4.6e-06     0.012       6      47 ..     345     384 ..     341     387 .. 0.93
   4 !    7.3   0.0    0.0028       7.1       3      49 ..     392     453 ..     390     454 .. 0.75
   5 !   21.8   0.0   8.8e-08   0.00022       1      41 [.     457     500 ..     457     509 .. 0.77
   6 !    6.6   0.0    0.0046        12       3      26 ..     514     538 ..     512     551 .. 0.81

  Alignments for each domain:
  == domain 1  score: 20.9 bits;  conditional E-value: 1.6e-07
                 EEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtval 50 
                 +ysWG n+   LG+ +  ++ +P+ +++ls++ + + acG++h ++l
  EFC38535.1 244 LYSWGLNT---LGRSNPTTNEYPVSLTLLSDEYIRQLACGASHALVL 287
                 7****775...99*99999999*********************9986 PP

  == domain 2  score: 31.1 bits;  conditional E-value: 1e-10
                 EEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtval 50 
                 +y+WG+n+yGqLG+g++++ ++Pt+v + s   v+ + +G + +v++
  EFC38535.1 292 IYGWGSNSYGQLGIGSKVDISLPTLVLSHS-GAVSYINAGPYTSVLI 337
                 8*************************5544.49999****9999876 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 4.6e-06
                 EEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEE CS
        RCC1   6 sWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddht 47 
                 sWGrn+++ LG g   ++++Pt ++     +++k++ G +h 
  EFC38535.1 345 SWGRNTEYNLGVGVWGDKTTPTIISATL--KFSKICFGMHHA 384
                 8***********************8877..*********997 PP

  == domain 4  score: 7.3 bits;  conditional E-value: 0.0028
                 EEEEEE--GGGTTSS...SS-...--EEEEEE-GGGTTS.........-EEEEEEETTEEEE CS
        RCC1   3 rVysWGrndyGqLGl...gtt...esvlvPtkveglsgn.........rvvkvacGddhtva 49 
                   y WGr  ++   +   +tt   ++++vP+ v++++            +v+  cGd+ t++
  EFC38535.1 392 TFYYWGRRGNNGVDRyviPTTtcfVNNNVPVNVTTPTTFptsfyptntAIVDFHCGDYSTIL 453
                 557777777776777776333467888999999777766777799999**********9987 PP

  == domain 5  score: 21.8 bits;  conditional E-value: 8.8e-08
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS...-EEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgn...rvvkva 41 
                 +G V+s+G n +G LG+g+++s+++P+ ++        +++k+a
  EFC38535.1 457 NGGVLSFGYNGNGALGTGDSVSSTTPVTIRKAVIGsyrKIIKIA 500
                 69************************999432222356888877 PP

  == domain 6  score: 6.6 bits;  conditional E-value: 0.0046
                 EEEEEE--GGGTTSSSS-.--EEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt.esvlvP 26 
                 r++ WG n+  q+ +g++  +++ P
  EFC38535.1 514 RLFVWGANNICQCATGKEcSTQWEP 538
                 89**************995555555 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   0.0   2.5e-05     0.065       5      29 ..     228     253 ..     225     254 .. 0.90
   2 !   26.2   0.4   1.9e-09     5e-06       1      30 []     274     302 ..     274     302 .. 0.93
   3 !   13.5   0.2   1.8e-05     0.046       4      27 ..     327     350 ..     317     352 .. 0.92
   4 ?    2.1   0.4     0.067   1.7e+02       3      27 ..     376     401 ..     374     403 .. 0.81
   5 !   15.6   1.5   4.1e-06      0.01       6      29 ..     446     469 ..     441     470 .. 0.93
   6 !    9.6   0.0   0.00032      0.82      11      27 ..     506     522 ..     487     526 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.5e-05
      RCC1_2   5 saGdyHscaLt.edGeVlcWGsNsdG 29 
                 + Gdy+ + L+ ++ ++++WG N+ G
  EFC38535.1 228 CTGDYFGLYLDpNTRILYSWGLNTLG 253
                 68*********88899*******988 PP

  == domain 2  score: 26.2 bits;  conditional E-value: 1.9e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++++G++H+++Lt+   +++WGsNs+GQ
  EFC38535.1 274 IRQLACGASHALVLTNKA-IYGWGSNSYGQ 302
                 689*********999875.**********9 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 1.8e-05
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNs 27 
                 + aG y s+ ++++G  ++WG+N+
  EFC38535.1 327 INAGPYTSVLIDNNGYARSWGRNT 350
                 789********************8 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.067
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGs.Ns 27 
                 ++++G  H+++++ +G+ + WG+  +
  EFC38535.1 376 KICFGMHHAIGVSQSGTFYYWGRrGN 401
                 6788889***************6344 PP

  == domain 5  score: 15.6 bits;  conditional E-value: 4.1e-06
      RCC1_2   6 aGdyHscaLtedGeVlcWGsNsdG 29 
                 +Gdy ++ L+++G Vl++G N++G
  EFC38535.1 446 CGDYSTILLLSNGGVLSFGYNGNG 469
                 9*********************99 PP

  == domain 6  score: 9.6 bits;  conditional E-value: 0.00032
      RCC1_2  11 scaLtedGeVlcWGsNs 27 
                 ++aL++d +++ WG N+
  EFC38535.1 506 TLALSDDRRLFVWGANN 522
                 9*************986 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.34   8.7e+02      18      32 ..     677     689 ..     675     692 .. 0.87
   2 !   14.2   0.0   1.2e-05     0.032       1      30 [.     707     737 ..     707     749 .. 0.83
   3 !   21.4   0.4   6.8e-08   0.00017       1      39 [.     762     800 ..     762     802 .. 0.96
   4 ?    1.3   0.0      0.14   3.6e+02       3      24 ..     814     835 ..     812     845 .. 0.72

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.34
     Kelch_5  18 YvyGGkvgrdgsvsd 32 
                 +++GG+v  ++ +sd
  EFC38535.1 677 FYFGGFV--NNTLSD 689
                 68*****..999888 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 1.2e-05
     Kelch_5   1 iPppRaghcavtvsekiYvyGGkvg.rdgsv 30 
                 +P p a++ ++ v+e +Y++GG +  rd++v
  EFC38535.1 707 LPYPVASGMVALVDEFLYIFGGLTLdRDEIV 737
                 699*********************9877776 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 6.8e-08
     Kelch_5   1 iPppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdl 39 
                 iP p++++ + ++++++Y+ GG+ ++++++++++y+ ++
  EFC38535.1 762 IPFPIYNGVVYVLDDSLYLLGGRAYPSNQPTSEIYIASI 800
                 7***********************************985 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.14
     Kelch_5   3 ppRaghcavtvsekiYvyGGkv 24 
                  p++    +++++ iY++GG+ 
  EFC38535.1 814 YPLSETNLIMDPDGIYLIGGFR 835
                 55555556677788******95 PP

>> Fibrinogen_C  Fibrinogen beta and gamma chains, C-terminal globular domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.0   1.8e-07   0.00047       3      51 ..     937     986 ..     936    1002 .. 0.88

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1.8e-07
                   SSHHHHH.HTT--S-EEEEE-SSTTS--EEEEEE-SCCCS-EEEEEEESS CS
  Fibrinogen_C   3 rdCedaa.kkGaktsglytitpdkakkafevyCdmetdggGWtvlqkrld 51 
                   + C++ + +  ++ sg y i pd++  +f vyC+    +gGWt++  r +
    EFC38535.1 937 KSCSEYLaRYPNQGSGFYWIWPDENSLNFVVYCEQSIADGGWTLVSSRSN 986
                   56777651456789*******************************99976 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.2       2.7   6.8e+03       2      21 ..     280     299 ..     279     304 .. 0.85
   2 ?   -2.2   0.3       2.3     6e+03       7      28 ..     385     402 ..     380     407 .. 0.74
   3 ?   -2.2   0.0       2.3     6e+03      15      30 ..     677     691 ..     664     699 .. 0.77
   4 ?   11.5   0.0   0.00011      0.29       5      24 ..     713     736 ..     709     755 .. 0.71
   5 ?    6.6   0.1     0.004        10       7      32 ..     770     797 ..     764     814 .. 0.80
   6 ?   -1.5   0.0       1.4   3.6e+03      11      20 ..     825     834 ..     821     837 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.7
     Kelch_6   2 raghslvsvggkiYifGGyt 21 
                  a+h+lv+ +  iY +G ++
  EFC38535.1 280 GASHALVLTNKAIYGWGSNS 299
                 57899*********999876 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2.3
     Kelch_6   7 l.vsvggkiYifGGytdsspyln 28 
                 + vs  g++Y++G +++     n
  EFC38535.1 385 IgVSQSGTFYYWGRRGN-----N 402
                 4488899******9988.....4 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 2.3
     Kelch_6  15 YifGGytdsspylnkv 30 
                 ++fGG ++ ++ ++++
  EFC38535.1 677 FYFGGFVN-NTLSDRI 691
                 789***99.6666665 PP

  == domain 4  score: 11.5 bits;  conditional E-value: 0.00011
     Kelch_6   5 hslvs.vggkiYifGGytds...s 24 
                   +v+ v++++YifGG+t +    
  EFC38535.1 713 SGMVAlVDEFLYIFGGLTLDrdeI 736
                 566555***********9876553 PP

  == domain 5  score: 6.6 bits;  conditional E-value: 0.004
     Kelch_6   7 lvs.vggkiYifGGytds.spylnkvwv 32 
                 +v   ++++Y++GG+  + +++++ +++
  EFC38535.1 770 VVYvLDDSLYLLGGRAYPsNQPTSEIYI 797
                 544489*********9999999998887 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 1.4
     Kelch_6  11 ggkiYifGGy 20 
                  + iY++GG 
  EFC38535.1 825 PDGIYLIGGF 834
                 589******6 PP

>> RloB  RloB-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   8.6e-05      0.22       4      55 ..      71     127 ..      69     173 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 8.6e-05
        RloB   4 vcEGekTEpiYFkalkelrrerkinagsntrsesekkksnpkklvekaiel...........k 55 
                 v+EG+kT +iY+++l ++++       +++++++++++ n  k v++ ++l           +
  EFC38535.1  71 VVEGQKTSEIYINELIQRKEL------RTMIIQKDEQWGNYTKQVDYQKKLvstqrraiamsR 127
                 89*************988888......5677899999*9999999999988666665555550 PP

>> Ribosomal_S5  Ribosomal protein S5, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.3       3.6   9.1e+03       5      22 ..      61      78 ..      60      78 .. 0.87
   2 ?   11.2   0.0   0.00011      0.29      31      64 ..     466     499 ..     461     500 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.6
                  EEEEEEEEEEETTEEEEE CS
  Ribosomal_S5  5 vlkikrvqkvtkgGrrts 22
                  ++++++ + ++  G++ts
    EFC38535.1 61 MVNMNKLSTMVVEGQKTS 78
                  588999999**9999986 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00011
                   ETTTEEEEEEEEESSHHHHHHHHHHHHHHTEEE- CS
  Ribosomal_S5  31 dgnGlvGlGvgkakevatAirkAiekAkknlvpv 64 
                   +gnG +G G   +++ ++ irkA++   ++++++
    EFC38535.1 466 NGNGALGTGDSVSSTTPVTIRKAVIGSYRKIIKI 499
                   9******************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1109 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       455  (0.0253779); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 6842.66
//
Query:       EFC38536.1  [L=311]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.9e-23   81.8  14.2    3.9e-23   81.8  14.2    2.8  3  PAP2_C        PAP2 superfamily C-terminal
    3.4e-08   33.3   8.0    3.4e-08   33.3   8.0    2.5  2  PAP2          PAP2 superfamily
  ------ inclusion threshold ------
      0.011   15.5   3.4      0.027   14.3   0.4    3.0  2  CoxIIa        Cytochrome c oxidase subunit IIa family
       0.04   13.6  18.4       0.02   14.6  15.0    2.2  1  PAP2_3        PAP2 superfamily
       0.28   10.1  17.9      0.053   12.4   4.5    2.1  2  MFS_1         Major Facilitator Superfamily
       0.61   10.3  15.4       0.06   13.6   2.6    2.7  2  DUF1516       Protein of unknown function (DUF1516)
          5    6.9  11.7       0.47   10.2   1.8    2.5  2  DUF2157       Predicted membrane protein (DUF2157)


Domain annotation for each model (and alignments):
>> PAP2_C  PAP2 superfamily C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.97   2.5e+03      16      31 ..      54      68 ..      36      82 .. 0.59
   2 ?   -0.5   0.5      0.72   1.8e+03      15      28 ..     116     129 ..      97     158 .. 0.56
   3 !   81.8  14.2   1.5e-26   3.9e-23       1      74 []     191     270 ..     191     270 .. 0.99

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.97
      PAP2_C 16 lavlfileyspkklai 31
                 ++lfi+++ +  l i
  EFC38536.1 54 RLFLFIMYFIATAL-I 68
                33444444444443.3 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.72
      PAP2_C  15 tlavlfileyspkk 28 
                 ++++++++   ++k
  EFC38536.1 116 VMMLMVAFFRKRNK 129
                 23333333333333 PP

  == domain 3  score: 81.8 bits;  conditional E-value: 1.5e-26
      PAP2_C   1 tCgDlifSGHtvvltlavlfileyspkkla......ilkvillllallglfliiasrkHYtvDVllglyittlvfllyhl 74 
                 tCgD++fSGH+++l+l+++f+++ys++  +      i+++il++++++g+flii++++HYtvDV+lg++i++++++lyh+
  EFC38536.1 191 TCGDYVFSGHATALILVFWFVWYYSHSDRWskavrmIFNTILFTVTFVGCFLIIVAKEHYTVDVILGVVISVMFCALYHM 270
                 7****************************9************************************************96 PP

>> PAP2  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   1.9      0.44   1.1e+03      54      54 ..     102     102 ..      44     158 .. 0.56
   2 !   33.3   8.0   1.3e-11   3.4e-08      50     132 ..     190     273 ..     152     276 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.44
        PAP2  54 e 54 
                  
  EFC38536.1 102 T 102
                 1 PP

  == domain 2  score: 33.3 bits;  conditional E-value: 1.3e-11
        PAP2  50 keakesfPSgHsafafalalllalllrrkrkkig.lvllalillllavlvalsRlylgvHflsDvlaGlliGialaalayrlvq 132
                 +++++   SgH+++  +++ +++++ ++ r+ +  + ++ +il++++++ ++  +++  H++ Dv+ G++i++++ al++ l +
  EFC38536.1 190 DTCGDYVFSGHATALILVFWFVWYYSHSDRWSKAvRMIFNTILFTVTFVGCFLIIVAKEHYTVDVILGVVISVMFCALYHMLLE 273
                 55566669***********************9888888888999999999999************************9997765 PP

>> CoxIIa  Cytochrome c oxidase subunit IIa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.4   1.1e-05     0.027      15      27 ..     202     214 ..     200     219 .. 0.92
   2 ?   -0.3   0.2      0.38   9.8e+02      15      23 ..     289     297 ..     289     299 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.1e-05
                 HHHHHHHHHHHHH CS
      CoxIIa  15 tatILvFWfgvFy 27 
                 ta ILvFWf+ +y
  EFC38536.1 202 TALILVFWFVWYY 214
                 899*******999 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.38
                 HHHHHHHHH CS
      CoxIIa  15 tatILvFWf 23 
                 ++ IL +Wf
  EFC38536.1 289 VISILHYWF 297
                 689*****9 PP

>> PAP2_3  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6  15.0   7.8e-06      0.02      14     187 ..      85     264 ..      79     267 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 7.8e-06
      PAP2_3  14 weaalnklllahpalavilalaYaslhfqvtllvlvllflrrrerlreflttlll.atll...gllvyalfPaagPrlleeagfvdtvaaaslagalrd 108
                 +e+a   +l++ p+++  + ++ ++l ++ ++++l+++f+r+r +l  f + l++ atll   +l +++   + +     ++   +  +  +l+ a+r+
  EFC38536.1  85 MEPARDVFLENLPHASQTAFTISEILALVGIVMMLMVAFFRKRNKLAIFHRYLFIhATLLnirTLCISVTTFSIPT----SEYKENCIRLQNLSLAERL 179
                 5666666788888888888888888888999999999998888888888776665144443334444444444444....2333444445555557788 PP

      PAP2_3 109 gasravllrgtienglaafPSlHvawallvalalwrlrrkr.llrvlalllnvlmivat.......vatgnHYlvDviaGvalalva 187
                 g++ +++  g   + ++   S H++  +lv +++w+++++  + +++ +++n +++++t       ++  +HY vDvi Gv++ ++ 
  EFC38536.1 180 GKALNITNFGDTCGDYVF--SGHATALILVFWFVWYYSHSDrWSKAVRMIFNTILFTVTfvgcfliIVAKEHYTVDVILGVVISVMF 264
                 888888777776666664..***************99877656677777777766655422223337889************98875 PP

>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   5.8     0.012        31     200     271 ..      49     133 ..      12     163 .. 0.56
   2 ?   12.4   4.5   2.1e-05     0.053     252     322 ..     201     268 ..     170     279 .. 0.74

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.012
       MFS_1 200 wkallkdpvlwillialllfffgfsglltllplylqevlgls..........glllaglllallalvgailallagrlsdr.....l 271
                  k+ll+   + +++ia +l++  f++l++ +p    + +  +          +  +a +++ +lalvg++++l+++++ +r     +
  EFC38536.1  49 GKSLLRLFLFIMYFIATALIT-KFTLLFFVIPRV-STNMEPArdvflenlphASQTAFTISEILALVGIVMMLMVAFFRKRnklaiF 133
                 233333332212222222222.333377777774.4444444555555566633888888999999999999999999888443331 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 2.1e-05
       MFS_1 252 llalvgailallagrlsdrlgrrrrlllallllllaalglallavt..ssavllllvlvliGfglgfvfpsll 322
                 ++al+ ++ +++    sdr+++  r++++ +l++++++g++l+ v+  + +v      v++G+  +++f++l 
  EFC38536.1 201 ATALILVFWFVWYYSHSDRWSKAVRMIFNTILFTVTFVGCFLIIVAkeHYTVD-----VILGVVISVMFCALY 268
                 56667777766666666*****************************5433333.....455555555555544 PP

>> DUF1516  Protein of unknown function (DUF1516)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   5.2      0.14   3.7e+02      46     103 ..      68     144 ..      30     148 .. 0.69
   2 ?   13.6   2.6   2.3e-05      0.06      10      88 ..     202     279 ..     197     294 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.14
     DUF1516  46 vtglvllirtfk...................nspllyilKvllgllvIglmEmalarkkkkksssgllilfivvlvl 103
                 +t ++ll+ ++                     s++ +++  +l+l+ I++m m+   +k++k +    +lfi +++l
  EFC38536.1  68 ITKFTLLFFVIPrvstnmepardvflenlphASQTAFTISEILALVGIVMMLMVAFFRKRNKLAIFHRYLFIHATLL 144
                 555555555444555555555555556666678889999999**********9999999999998888888877776 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 2.3e-05
     DUF1516  10 lliilfivalllyskgkskaakilhmilRlfyllilvtglvllirtfknspllyilKvllgllvIglmEmalarkkkkk 88 
                  ++il+++ +  ys+ +++ +k + mi   ++  +   g  l+i + ++ ++ +il v++ ++  +l  m+l r  ++k
  EFC38536.1 202 TALILVFWFVWYYSH-SDRWSKAVRMIFNTILFTVTFVGCFLIIVAKEHYTVDVILGVVISVMFCALYHMLLERHVQDK 279
                 567777777777777.7799*******988888877788888888888************************9998866 PP

>> DUF2157  Predicted membrane protein (DUF2157)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   2.7     0.097   2.5e+02      72      85 ..     109     123 ..      45     164 .. 0.58
   2 ?   10.2   1.8   0.00018      0.47      48     112 ..     202     270 ..     176     274 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.097
     DUF2157  72 vllllslllg.avlw 85 
                 +l+l+ ++++ +v+ 
  EFC38536.1 109 ILALVGIVMMlMVAF 123
                 222222222222222 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00018
     DUF2157  48 lGlilfvAanW.....qglsrlvkfllllvllllslllgavlwrdrrvpprlgeallllaalllgaaial 112
                 ++lil++  +W     +++s++v+++   +l+ +++++ +++    +++ ++  +l+++ +++++a++ +
  EFC38536.1 202 TALILVFWFVWyyshsDRWSKAVRMIFNTILFTVTFVGCFLIIVA-KEHYTVDVILGVVISVMFCALYHM 270
                 5667777777777777***********************666664.677788888999999999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1173  (0.0654247); expected 358.6 (0.02)
Passed bias filter:                      437  (0.0243739); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 1909.70
//
Query:       EFC38537.1  [L=130]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.8e-05   23.1  95.4      0.025   14.5  37.7    3.0  2  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -22.6  79.4         1   1.8e+04      60     101 ..      30      70 ..       1     103 [. 0.45
   2 !   14.5  37.7   1.4e-06     0.025      60     113 ..      69     122 ..      68     129 .. 0.54

  Alignments for each domain:
  == domain 1  score: -22.6 bits;  conditional E-value: 1
  Trypan_PARP  60 epepepepepepepepepep.etepeeepepepepepepepep 101
                  +p+p+p+p+p+p+p+p+p+p +  p+++p+p+p+p+p+p+p+p
   EFC38537.1  30 NPNPNPNPNPNPNPNPNPNPpK--PKPKPKPKPKPKPKPKPKP 70 
                  2222222222222222222221..1111111111111111111 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 1.4e-06
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepepepga 113
                  +p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p  
   EFC38537.1  69 KPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPTP 122
                  455555555555555555555555555555555555566666666666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       305  (0.0170115); expected 358.6 (0.02)
Passed bias filter:                       93  (0.00518713); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.42
# Mc/sec: 924.99
//
Query:       EFC38538.1  [L=432]
Description: Hypothetical protein NAEGRDRAFT_73574 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       433  (0.0241508); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.24s 00:00:00.69 Elapsed: 00:00:00.39
# Mc/sec: 3282.35
//
Query:       EFC38539.1  [L=208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.021   15.2   0.1      0.033   14.5   0.1    1.3  1  Ly49           Ly49-like protein, N-terminal region
        0.5   10.5   8.7      0.081   13.0   4.6    1.7  2  Podoplanin     Podoplanin
       0.71    8.5   5.2       0.96    8.1   5.2    1.1  1  TctA           Tripartite tricarboxylate transporter TctA fam
       0.75   10.0   3.7       0.86    9.9   2.6    1.7  1  Glycophorin_A  Glycophorin A


Domain annotation for each model (and alignments):
>> Ly49  Ly49-like protein, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.1   7.4e-06     0.033       6      74 ..     116     184 ..     112     207 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 7.4e-06
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..H CS
        Ly49   6 livvalgILclllLvtvavLvtkifqysqekheleetlnlsqnysimqndinlkeelLrnkslecsilk 74 
                 +i +++g+L+ + Lv+v+v+ +k+   ++  ++ +   n  q  +  + +++lkee+ r++s  +s+  
  EFC38539.1 116 IIGIIFGVLIGIGLVVVIVILLKVPSLIRRFKNRNSSNNNLQLIQDENLQVQLKEEISRERSGIISNDA 184
                 5889********************99999988888887777777777788999**99999874443322 PP

>> Podoplanin  Podoplanin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   4.6   1.8e-05     0.081     127     151 ..     112     136 ..      79     145 .. 0.82
   2 ?   -1.7   0.1      0.62   2.8e+03      72      93 ..     176     197 ..     160     205 .. 0.56

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.8e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXX CS
  Podoplanin 127 atvtLvgiivGvllaigfiggiiiv 151
                 +  +++gii Gvl++ig++  i+i+
  EFC38539.1 112 THGSIIGIIFGVLIGIGLVVVIVIL 136
                 55789**************877775 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.62
                 XXX-----GGG-XXXXXXXXXX CS
  Podoplanin  72 tesvtdlrledlptaestvkak 93 
                 +  + ++ ++d+ t +st+ ++
  EFC38539.1 176 RSGIISNDANDQNTFQSTTYNR 197
                 4444455555555555555443 PP

>> TctA  Tripartite tricarboxylate transporter TctA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   5.2   0.00021      0.96       3      31 ..     110     138 ..     109     145 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00021
        TctA   3 lvllGvllGtliGllPGlhatlavalllp 31 
                 ++  G ++G+++G+l+G++ ++++++ll 
  EFC38539.1 110 VITHGSIIGIIFGVLIGIGLVVVIVILLK 138
                 5778*********************9986 PP

>> Glycophorin_A  Glycophorin A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   2.6   0.00019      0.86      57      92 ..     113     153 ..     107     170 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00019
                    -TTHHHHHHHHHHHH.....HHHHHHHHHHHHTHSXXXXXX CS
  Glycophorin_A  57 elvitliifgvmAgv.....igtillisYlirRliKKssvd 92 
                    +  i++iifgv+ g+     i ++l +  lirR++ + s++
     EFC38539.1 113 HGSIIGIIFGVLIGIglvvvIVILLKVPSLIRRFKNRNSSN 153
                    6789*******987432221444444778999998887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1380  (0.0769703); expected 358.6 (0.02)
Passed bias filter:                      682  (0.0380389); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1184.51
//
Query:       EFC38540.1  [L=687]
Description: hypothetical protein NAEGRDRAFT_81535 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.9e-20   72.9  13.5    2.9e-20   72.9  13.5    2.2  2  FA_hydroxylase  Fatty acid hydroxylase superfamily
  ------ inclusion threshold ------
      0.038   13.7   0.0      0.088   12.6   0.0    1.5  1  PTEN_C2         C2 domain of PTEN tumour-suppressor protein


Domain annotation for each model (and alignments):
>> FA_hydroxylase  Fatty acid hydroxylase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.9  13.5   3.3e-24   2.9e-20       3     133 .]     144     276 ..     142     276 .. 0.91
   2 ?   -2.0   0.0      0.49   4.3e+03      50      71 ..     389     411 ..     377     448 .. 0.57

  Alignments for each domain:
  == domain 1  score: 72.9 bits;  conditional E-value: 3.3e-24
  FA_hydroxylase   3 lallledfveYwvHrllHrvkllwrrlHkvHHsseaptalaalrahplealllallllllllllg.plsalllvlvlaallelliHsglhvslgw 96 
                     ++l+++d  +Yw Hr  H+ ++ w+  H vHHsse+ + ++alr+   + +++  l++++++++g ++  + ++  ++ + +++ H+   ++l+ 
      EFC38540.1 144 MVLIFYDHQYYWSHRYAHEWNIGWA-GHNVHHSSEEYNLTSALRQGAYQDCTTF-LFYIPMAIAGiHPYFFSIHSNINLVGQFWFHTRAIRKLPS 236
                     67999*************9555999.*******************998887765.66678888888**********************8899999 PP

  FA_hydroxylase  97 llerllatpraHrlHHskneeg...nfgvllslwDrlfgT 133
                      le++l+tp++Hr+HH +ne +   n+g +l ++Dr++gT
      EFC38540.1 237 PLEWILNTPSHHRVHHGRNEYCldkNYGGVLIIFDRIYGT 276
                     99******************55888**************9 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.49
  FA_hydroxylase  50 lealllallllllllllg.plsa 71 
                     +e  l+++ +++ ++l+  ++++
      EFC38540.1 389 FEKHLATIHFAITFVLYLlHMET 411
                     55555543333333333223333 PP

>> PTEN_C2  C2 domain of PTEN tumour-suppressor protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   9.8e-06     0.088      85     127 ..     219     504 ..     204     507 .. 0.97

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 9.8e-06
                 EEEEEEEEEGGGS-T.................................................................................... CS
     PTEN_C2  85 ekmfrvwfnTsfiek.................................................................................... 99 
                 + ++++wf+T  i+k                                                                                    
  EFC38540.1 219 NLVGQFWFHTRAIRKlpsplewilntpshhrvhhgrneycldknyggvliifdriygtfepeqemetedpirkeksnvvyglttplttfdpiqtqnhli 317
                 5689*********************************************************************************************** PP

                 ................................................................................................... CS
     PTEN_C2 100 ................................................................................................... 99 
                                                                                                                    
  EFC38540.1 318 vsilqtcmeissksthsvfkgksqlfiwwnrlqvifrgpgwncftqgwyecpkvltppsknqmydpqtnppfekhlatihfaitfvlyllhmetnfdsl 416
                 *************************************************************************************************** PP

                 ............................................................T--EEEEEGGG-BS---G...GGS-TT- CS
     PTEN_C2 100 ............................................................nqnvltltkneLDkalkdkadkkfsknf 127
                                                                             ++++++++k ++D+++ + ++ +f++n 
  EFC38540.1 417 inqlsqllfiylslssissiyedssskklhelirlsfsnlfllfkyygdnnwigrmlpgsQTTIIKMQKANMDNTDSESTSGNFNNNN 504
                 ***********************************************************9999***************9999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (687 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       879  (0.0490267); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 3920.56
//
Query:       EFC38541.1  [L=1181]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.2e-06   25.6   0.9      7e-05   22.6   0.1    2.7  2  LisH      LisH
  ------ inclusion threshold ------
        1.9    9.5   4.1        6.7    7.8   0.0    3.6  4  WD40      WD domain, G-beta repeat


Domain annotation for each model (and alignments):
>> LisH  LisH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.1   7.8e-09     7e-05       1      27 []     669     695 ..     669     695 .. 0.97
   2 ?    0.4   0.1     0.082   7.3e+02       2      12 ..     715     725 ..     714     727 .. 0.88

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 7.8e-09
                 HHHHHHHHHHHHHCT-HHHHHHHHHHT CS
        LisH   1 eeLNrLIydYLvkeGyeetAeaFekEa 27 
                 +eL +LI++YL ++G++e+A+ ++kEa
  EFC38541.1 669 DELLQLIHEYLDNKGLVESAKCLMKEA 695
                 69************************8 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.082
                 HHHHHHHHHHH CS
        LisH   2 eLNrLIydYLv 12 
                 +L+r++ +YL+
  EFC38541.1 715 LLDRIVVNYLR 725
                 79********7 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0   0.00075       6.7       9      38 .]     802     832 ..     795     832 .. 0.83
   2 ?    0.2   0.0      0.19   1.7e+03      17      33 ..     891     911 ..     871     911 .. 0.71
   3 ?   -2.7   0.0       1.5   1.3e+04      17      27 ..     937     947 ..     918     953 .. 0.74
   4 ?   -1.3   0.1      0.55     5e+03       5      25 ..    1051    1070 ..    1048    1078 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00075
                 SSSS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   9 GHss.vtslafspdgawlasGsdDgtvriWd 38 
                 G s  ++s+af pd++ + ++sd g + i+d
  EFC38541.1 802 GESEiISSIAFAPDSSKIYCSSDEGDLFIYD 832
                 5534479************99*9**999998 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.19
                 E....EETTSSEEEEEETTSE CS
        WD40  17 a....fspdgawlasGsdDgt 33 
                 +    fs  ++++a++s D t
  EFC38541.1 891 CfsatFSNGNDLVAASSFDTT 911
                 044559*******99988876 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.5
                 EEETTSSEEEE CS
        WD40  17 afspdgawlas 27 
                 +fsp+ +++++
  EFC38541.1 937 CFSPYDDLVLA 947
                 48999999763 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.55
                  EEEESSSSEEEEEEETTSSEE CS
        WD40    5 rtltGHssvtslafspdgawl 25  
                  +t++ H  +++++ +p  +++
  EFC38541.1 1051 HTFERH-EIHDISIDPVYNYV 1070
                  788888.8****999988885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1168  (0.0651459); expected 358.6 (0.02)
Passed bias filter:                      602  (0.0335769); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.01u 0.38s 00:00:01.39 Elapsed: 00:00:00.58
# Mc/sec: 6163.90
//
Query:       EFC38542.1  [L=798]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.057   12.7   0.0        0.1   11.8   0.0    1.4  1  Pyr_redox_3    Pyridine nucleotide-disulphide oxidoreductase
      0.064   12.5   0.0        5.3    6.2   0.0    2.4  2  FAD_binding_3  FAD binding domain


Domain annotation for each model (and alignments):
>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   1.2e-05       0.1       1      30 [.     197     225 ..     197     244 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.2e-05
  Pyr_redox_3   1 iIiGaGPaGlaaaielkkagledylilEkg 30 
                  i+iG GP+Gl +aie+  +   ++ i+Ek 
   EFC38542.1 197 IVIGSGPIGLLSAIEASLLLP-KLYIIEKR 225
                  89**************99987.688***97 PP

>> FAD_binding_3  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0    0.0035        32       5      34 ..     197     226 ..     194     232 .. 0.73
   2 ?    6.2   0.0    0.0006       5.3     152     197 ..     393     435 ..     364     465 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0035
                    EEE--SHHHHHHHHHHHHTTHHEEEEESSS CS
  FAD_binding_3   5 lIVGaGpaGlmlallLseaGvrvvlvekrs 34 
                    +++G+Gp Gl++a + s    +  ++ekr+
     EFC38542.1 197 IVIGSGPIGLLSAIEASLLLPKLYIIEKRT 226
                    79*********9987655544566666665 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0006
                    EEEEEEEEE--GTT-HHHHHHTGGEEEEEEEEEEEEEEEEEEC-SC CS
  FAD_binding_3 152 tvrakYlvGaDGgrStvrktlgiefegeetvyeagvldvlfdadls 197
                    ++  + l+G DG  Stvr++l i+   ++++  ++v ++l ++ ls
     EFC38542.1 393 RIPFDILIGSDGLYSTVRSSLNIT---TRDIHSFDVSNTLYAQTLS 435
                    5556679***************98...5555556666666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (798 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       766  (0.0427241); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.53
# Mc/sec: 4522.33
//
Query:       EFC38543.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-55  187.1  13.4      4e-55  187.0  13.4    1.0  1  Rtf2           Rtf2 RING-finger
     0.0055   16.8   0.2      0.017   15.2   0.0    1.9  2  zf-NOSIP       Zinc-finger of nitric oxide synthase-interacti
  ------ inclusion threshold ------
      0.085   12.6   0.2       0.14   12.0   0.2    1.4  1  Flag1_repress  Repressor of phase-1 flagellin
       0.12   12.3   3.7       0.39   10.7   3.7    1.9  1  zf-RING_5      zinc-RING finger domain
       0.21   11.4   0.0       0.21   11.4   0.0    3.0  3  zf-Nse         Zinc-finger of the MIZ type in Nse subunit
        3.8    8.0   7.1        1.7    9.1   0.5    2.7  2  Vps39_2        Vacuolar sorting protein 39 domain 2


Domain annotation for each model (and alignments):
>> Rtf2  Rtf2 RING-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  187.0  13.4   1.3e-58     4e-55       1     212 [.       1     221 [.       1     229 [] 0.87

  Alignments for each domain:
  == domain 1  score: 187.0 bits;  conditional E-value: 1.3e-58
        Rtf2   1 mGnDGGsi.pkRdelvkekkkkekvdkeeekearwklCaLsqepLkkPivadrlGkLYnkdavleaLldkskekslskaashikglkdvvelkltknpa 98 
                 mG+DGG++ ++Rd  vk+kk+ +k dke+++ + w+lC L++epL+ Piv+d++G LYnk ++le L+dk+k+k+ ++ + hi +l d+ ++ l+knp+
  EFC38543.1   1 MGADGGTLcDRRDIIVKTKKQDKKPDKEAVNFTIWNLCRLTKEPLHDPIVMDKVGFLYNKTSLLECLIDKKKKKKHKEIIGHIGKLSDINDVILEKNPD 99 
                 9*******78888899*******************************************************99************************** PP

        Rtf2  99 feeskk......datkdtkeapfiCpltglemngktkfvalrkCGcVfsekalkevk.sevClvCgkeykeedviplnptke.elellkarleeekakk 189
                 f+e++k       a +  ++++fiCp+ + e+ g++    + +CG+V+seka+  +k +  C+ C+k+++e+d+i +np+    +e++++ + e++ +k
  EFC38543.1 100 FSEEDKaetmdkTAVSLIRKSRFICPVLREEIRGQFSVYCISSCGHVMSEKAIGLAKkDGCCMLCEKPFQESDIIKVNPESTaAKEIIEQIISEKSNEK 198
                 **9999877766666777899*********************************998567799****************99956666777777777777 PP

        Rtf2 190 kkkkkakkkkkakakgskaeaea 212
                 k kk +k+++++k+k+s+  +e+
  EFC38543.1 199 KRKKTTKEETNKKSKTSSIANEE 221
                 77776666666655555544444 PP

>> zf-NOSIP  Zinc-finger of nitric oxide synthase-interacting protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   5.7e-06     0.017      40      75 .]      35      71 ..      18      71 .. 0.81
   2 ?   -2.3   0.0       1.7   5.1e+03      41      50 ..     159     168 ..     150     189 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 5.7e-06
    zf-NOSIP 40 fdccslslqacrdpvlted.gylyekeaileyilhqk 75
                ++ c l+ ++ +dp++ +  g+ly+k ++le ++ +k
  EFC38543.1 35 WNLCRLTKEPLHDPIVMDKvGFLYNKTSLLECLIDKK 71
                799***********987544**********9988765 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.7
    zf-NOSIP  41 dccslslqac 50 
                  cc l  ++ 
  EFC38543.1 159 GCCMLCEKPF 168
                 5888766655 PP

>> Flag1_repress  Repressor of phase-1 flagellin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.2   4.6e-05      0.14      32      98 ..     137     206 ..     126     229 .] 0.75

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.6e-05
  Flag1_repress  32 vrlvsedarvitgyvaklnskenkvdlsdkpfdkekrielklerla...ilesgvteliandatnlslvh 98 
                    v  +s  ++v++    +l  k+    l++kpf++ + i+++ e+ a   i+e  ++e + +   ++++ +
     EFC38543.1 137 VYCISSCGHVMSEKAIGLAKKDGCCMLCEKPFQESDIIKVNPESTAakeIIEQIISEKSNEKKRKKTTKE 206
                    66677888999999999**************************998444677777777766666555544 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   3.7   0.00013      0.39      14      44 .]     137     166 ..     123     166 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00013
   zf-RING_5  14 kfyltsCgHifCekClkkllekeavCpiCrk 44 
                  +++ sCgH++ ek +  ++ k+ +C +C+k
  EFC38543.1 137 VYCISSCGHVMSEKAIGLAK-KDGCCMLCEK 166
                 49******************.9999999*86 PP

>> zf-Nse  Zinc-finger of the MIZ type in Nse subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0     7e-05      0.21      13      44 ..      37      72 ..      29      81 .. 0.83
   2 ?    0.6   0.6      0.17     5e+02      29      39 ..     142     152 ..     111     176 .. 0.69
   3 ?   -3.2   0.1       2.5   7.5e+03      36      44 ..     184     196 ..     181     205 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 7e-05
                B-TTTSSB-SSEEEESSS--EEEHHHHHHHC....T CS
      zf-Nse 13 kCPltlqpfeePvtskkCpHvFEreaIleli....k 44
                 C lt++p+++P+   k    ++++++le +    k
  EFC38543.1 37 LCRLTKEPLHDPIVMDKVGFLYNKTSLLECLidkkK 72
                5***************************99965421 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.17
                 SS--EEEHHHH CS
      zf-Nse  29 kCpHvFEreaI 39 
                  C Hv  ++aI
  EFC38543.1 142 SCGHVMSEKAI 152
                 57777666666 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.5
                 HHHHHHHC....T CS
      zf-Nse  36 reaIleli....k 44 
                 +e I+++i    +
  EFC38543.1 184 KEIIEQIIseksN 196
                 5677777755441 PP

>> Vps39_2  Vacuolar sorting protein 39 domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.5   0.00058       1.7      77     101 ..     157     182 ..     111     189 .. 0.87
   2 ?    1.4   1.4      0.14   4.2e+02      53      82 ..     196     225 ..     182     228 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00058
     Vps39_2  77 eekvCavCkkrlge.svfvvyPngsv 101
                 ++  C++C+k ++e  ++ v P+++ 
  EFC38543.1 157 KDGCCMLCEKPFQEsDIIKVNPESTA 182
                 56689*********889999999875 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.14
     Vps39_2  53 lrkaeklsveeellklrskkvvvteekvCa 82 
                  +k++k+ ++ee  k+++++ + +ee++C+
  EFC38543.1 196 NEKKRKKTTKEETNKKSKTSSIANEEHICK 225
                 456677788888888888888899999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2445  (0.136371); expected 358.6 (0.02)
Passed bias filter:                      612  (0.0341346); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.35s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 1274.00
//
Query:       EFC38544.1  [L=105]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0028   17.5   0.0     0.0031   17.3   0.0    1.2  1  RIF5_SNase_2  TbRIF5 SNase domain 2


Domain annotation for each model (and alignments):
>> RIF5_SNase_2  TbRIF5 SNase domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   1.8e-07    0.0031      27      76 ..      39      88 ..       8     102 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.8e-07
  RIF5_SNase_2 27 lpeliiLDavvCdeestekGyaalRwaqksllhkelevlvhsliPSdkdv 76
                    ++ iLD++v    s ++ y+a  w q +l  +    +++ ++P +++ 
    EFC38544.1 39 QYNIAILDSIVQSIASNSNMYQAYDWNQLYLYLSYKIHHIRQIYPNNQEN 88
                  56789*****************************9999*******99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       981  (0.0547158); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 607.33
//
Query:       EFC38545.1  [L=320]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.3e-34  118.9   0.6    3.5e-34  118.3   0.1    1.5  2  Ribosomal_L27A  Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27
  ------ inclusion threshold ------
      0.031   14.4   0.0        0.4   10.8   0.0    2.4  2  Mrr_N           Mrr N-terminal domain


Domain annotation for each model (and alignments):
>> Ribosomal_L27A  Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       1.2   1.1e+04      92     106 ..      62      77 ..      35      91 .. 0.52
   2 !  118.3   0.1   3.9e-38   3.5e-34       1     126 [.     110     238 ..     110     240 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.2
                     EEEE--S---.-.-EE CS
  Ribosomal_L27A  92 vKvlgkgeltkk.lkv 106
                     +K l k+e  k+ ++v
      EFC38545.1  62 IKPLKKKEAYKQfIEV 77 
                     3333333333333333 PP

  == domain 2  score: 118.3 bits;  conditional E-value: 3.9e-38
                     GGGGTSSTTTTTTTTT-S--......S--.........---GGG..---EEEEHHHHHHTTTTGTTS------EEEGGGTTTTSSS......SEE CS
  Ribosomal_L27A   1 kGktgGrGhkGqkkrsgvkkkpgfeGGqmplyrrlpkrGfknskfkkeykvvnlkdLdelideerleladeaeeidleelaeaglikk..kdgvK 93 
                     +Gkt+GrG+ G  +r+g++   gfeGGq+pl rr+pk Gf+n kfk +y++vnl++++ lid++r++   + ++i++++l+eaglik+    g+K
      EFC38545.1 110 RGKTCGRGRGGLYSRNGINLPVGFEGGQTPLWRRVPKYGFRNGKFKLNYQEVNLEQIQFLIDSGRIDIS-QGATITMRTLKEAGLIKNpkYPGIK 203
                     59***************999**********************************************864.79****************978899* PP

                     EE--S..---.--EEEESEE-HHHHHHHHHTT-EE CS
  Ribosomal_L27A  94 vlgkg..eltkklkvkaskfSkkAkekIeaaGGkv 126
                     +l+kg   l++k+++++ ++Sk+A+++Ie++GG+v
      EFC38545.1 204 LLAKGkeFLRSKIDIEVPRASKEAIKAIESVGGSV 238
                     ****97446889*********************98 PP

>> Mrr_N  Mrr N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0     0.063   5.6e+02      25      60 ..       3      38 ..       1      54 [. 0.85
   2 ?   10.8   0.0   4.5e-05       0.4      57      86 ..     184     213 ..     155     214 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.063
       Mrr_N 25 ervaerfglseeeraellpsgkqtrfknrvgWarty 60
                + +++++ + +  ++++ +sg  + + +r++++ t 
  EFC38545.1  3 RVIQNYLAVAPSTLKKVQTSGVASSLLQRMSFCTTS 38
                556677799999999999999999999999999885 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 4.5e-05
       Mrr_N  57 artyLkkagllespkrgvwkiTekGrevlk 86 
                  + +Lk+agl+++pk   +k+  kG+e+l+
  EFC38545.1 184 TMRTLKEAGLIKNPKYPGIKLLAKGKEFLR 213
                 5679************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       860  (0.047967); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1843.18
//
Query:       EFC38546.1  [L=547]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.9e-30  105.1  23.4    1.9e-20   73.6   0.1    3.3  4  Peptidase_M48_N  CAAX prenyl protease N-terminal, five membra
    1.4e-29  103.3   0.0    2.3e-29  102.6   0.0    1.3  1  Peptidase_M48    Peptidase family M48
  ------ inclusion threshold ------
       0.03   13.9   0.4      0.077   12.6   0.1    1.7  2  DUF2268          Predicted Zn-dependent protease (DUF2268)
      0.033   14.5   0.0      0.077   13.3   0.0    1.6  1  Yop-YscD_cpl     Inner membrane component of T3SS, cytoplasmi
       0.04   14.1   0.4       0.26   11.5   0.0    2.5  3  DUF872           Eukaryotic protein of unknown function (DUF8
       0.11   12.6   0.1       0.33   11.1   0.1    1.8  1  DUF2371          Uncharacterised conserved protein (DUF2371)


Domain annotation for each model (and alignments):
>> Peptidase_M48_N  CAAX prenyl protease N-terminal, five membrane helices
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.6   0.1   6.2e-24   1.9e-20       2     115 ..      47     163 ..      46     168 .. 0.93
   2 !   41.4   8.7   4.5e-14   1.3e-10     118     181 ..     255     318 ..     251     319 .. 0.96
   3 ?   -1.5   0.7      0.64   1.9e+03      70     105 ..     402     433 ..     386     449 .. 0.55
   4 ?   -2.2   0.0       1.1   3.3e+03      39      95 ..     450     506 ..     445     515 .. 0.69

  Alignments for each domain:
  == domain 1  score: 73.6 bits;  conditional E-value: 6.2e-24
  Peptidase_M48_N   2 lrklketkkvPeeladaitkekfdksraYgldksrfglvsslyslilllallllgllpflwklsgkl....lgldaeseilqslvfllllslis 91 
                       ++lk + ++P++l+++++k++fd +r+Y++ ++ f+ ++++y++i ++++ll g+l ++ +ls k+    ++l +e  i++++ fl+l+sl+s
       EFC38546.1  47 SKLLKTS-NIPSKLQKYLDKDEFDDMRNYSILRLGFSRLENAYGFITEVVILLSGVLTWIFDLSLKInillFSLGEEYAITRGVTFLFLVSLLS 139
                      5556655.6**********************************************************998777799****************** PP

  Peptidase_M48_N  92 tlislPfslYstFviEekhGfnkq 115
                      tl+  Pf++Y+ Fvi+ k+   kq
       EFC38546.1 140 TLVRAPFEVYRIFVIDGKFFETKQ 163
                      *****************9966666 PP

  == domain 2  score: 41.4 bits;  conditional E-value: 4.5e-14
  Peptidase_M48_N 118 klfikdklkslllalviglpllaallwiiewggeyfylylwlfllvfslllmtiyPtlIaPLFn 181
                      + +i+d++k+ ++++vig+pll+++lw+++ g +  ++y+w+  +++ + +  +yP++ aP+Fn
       EFC38546.1 255 RNWIMDQIKMGIISVVIGTPLLFLILWLLTTGSPIHWVYMWVGSVALAVGIYELYPIILAPMFN 318
                      67*************************************************************9 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.64
  Peptidase_M48_N  70 gldaeseilqslvfllllslistlislPfslYstFv 105
                      +++++ +il+s vf l ++l    + l f++Y+++ 
       EFC38546.1 402 KMNHSIKILTSQVFSLGIFL----FILSFTIYNEYF 433
                      44444444444444433333....334455554444 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 1.1
  Peptidase_M48_N  39 lvsslyslilllallllgllpflwklsgkllgldaeseilqslvfllllslistlis 95 
                      l+s l++ + ++a+++l+ ++  ++ s++ ++++   +i   l+ + ++ +++ +++
       EFC38546.1 450 LFSYLFQPLGNFAMVILNHIQRKYEYSSDEYSMSLGYNIEEPLIKMHVNNVYNLIVD 506
                      567777777777888888888777777776667777777777777777777777775 PP

>> Peptidase_M48  Peptidase family M48
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  102.6   0.0   7.6e-33   2.3e-29       3     195 ..     324     529 ..     322     530 .. 0.89

  Alignments for each domain:
  == domain 1  score: 102.6 bits;  conditional E-value: 7.6e-33
                    -SSHHHHHHHHHHHHTT-..-EEEEEEE-GGGT....-EEEEESSS-EEEEEEHHHH...-SSB-HHHHHHHHHHHHHHHHTTHHHHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M48   3 reaelkevveelakeaglpkpltkvyvvnspkr....NAFalgggknkrivltdgLl...kqllseeelaaVlGHElGHikhrhsvvslivsllas 91 
                    +e+ l++ +eel  ++g+  p ++++ v+++kr    NAF++g g+nk+ivl+d L+     +l+++e++a+l+HE+ H+k++hs++ l  ++ + 
     EFC38546.1 324 PEGPLRKSIEELTIKVGI--PVKDIVYVDGSKRhenaNAFMIGSGENKKIVLYDNLIskdGLNLTNDEILAILAHEIHHYKMNHSIKILTSQVFSL 417
                    57789999**********..99*******99999***********************7666799*********************88865555555 PP

                    HHHHHHHHHHTT-SHHHHHTT--S---HHHHHHHHHHTT...........HHHHHHHHHHHHHHHHTTT.HHHHHHHHHHHHHHTT--S---HHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M48  92 illllglallisraeedaagafldalavliglliillfl...........alSRkrEyqADeagvellkrakdlvraliklakdlerqdvsaslrs 176
                     ++l+ l+++i ++   ++++f+++ + + + l   lf+            ++Rk Ey++De++++l++   +  + lik++ ++  +   + l+s
     EFC38546.1 418 GIFLFILSFTIYNEYFYNSFGFTEIDPSVGLCLFSYLFQplgnfamvilnHIQRKYEYSSDEYSMSLGY---NIEEPLIKMHVNNVYNLIVDRLYS 510
                    566666778999999999***99998887665544444478****************************...8889******************** PP

                    HHS-SS--HHHHHHHHHH- CS
                    xxxxxxxxxxxxxxxxxxx RF
  Peptidase_M48 177 ellstHPplleRiqalkel 195
                     ++ +HP+lleR+ +lk++
     EFC38546.1 511 SYYNAHPSLLERVDNLKKW 529
                    *****************98 PP

>> DUF2268  Predicted Zn-dependent protease (DUF2268)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0         1   3.1e+03     106     135 ..     201     229 ..     183     240 .. 0.64
   2 ?   12.6   0.1   2.6e-05     0.077      20      83 ..     340     408 ..     323     417 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1
     DUF2268 106 telvgeeklapwtskldeetleellkkvik 135
                 ++ +g+e+ +    k dee+  ++++++ +
  EFC38546.1 201 KMFFGDEQ-GDNSVKSDEEETTSQYNEISN 229
                 44555555.555566666666666666655 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 2.6e-05
     DUF2268  20 dvdvf.ilpvneenrklieekgykgglaipdkiflflleneyske.......rlaallaHEyhHvvrlkqle 83 
                  ++v  i+ v+ ++r   + ++   g + ++ki+l+  +n  sk+       ++ a+laHE+hH    ++++
  EFC38546.1 340 GIPVKdIVYVDGSKRH-ENANAFMIGSGENKKIVLY--DNLISKDglnltndEILAILAHEIHHYKMNHSIK 408
                 5555566666666644.4444555666777788887..33333334447778************98777665 PP

>> Yop-YscD_cpl  Inner membrane component of T3SS, cytoplasmic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   2.6e-05     0.077      14      88 ..     356     424 ..     349     426 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.6e-05
                   ETTEEEEEES-TT-SEE---TTS-TT-EEEEEETTEEEEEE-CESS--EETTEE-SECC--TTSEEEETTEEEEE CS
  Yop-YscD_cpl  14 LeegevviGsdedcDivLsDkevsrkhlkLeveeesvrledlgsrngllvngerveelelrpgdvlelGttelal 88 
                    + ++++iGs+e+  ivL D+ +s+  l L+ +e    l       ++ + ++++ + ++ + +v++lG++++ l
    EFC38546.1 356 ENANAFMIGSGENKKIVLYDNLISKDGLNLTNDEILAILA-----HEIHHYKMNH-SIKILTSQVFSLGIFLFIL 424
                   57899*********************99998766544444.....4455555555.3556677777777777665 PP

>> DUF872  Eukaryotic protein of unknown function (DUF872)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   8.7e-05      0.26      45     100 ..     261     314 ..     210     325 .. 0.77
   2 ?   -1.2   0.0      0.75   2.2e+03      38      67 ..     402     429 ..     384     434 .. 0.66
   3 ?   -3.3   0.0       3.4     1e+04      18      44 ..     472     498 ..     466     503 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 8.7e-05
      DUF872  45 vvlaallLlllGlvLlllgvvilvepseGvssavflvlGlllfiPGvYhvvyiyla 100
                  + + ++ +++G+ Ll+l +++l++ s+   ++v++ +G +++  G+Y+ + i la
  EFC38546.1 261 QIKMGIISVVIGTPLLFLILWLLTTGSP--IHWVYMWVGSVALAVGIYELYPIILA 314
                 577788999*********9999987654..79*****************9998876 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.75
      DUF872  38 kvkknrkvvlaallLlllGlvLlllgvvil 67 
                 k+++ +k +     +  lG+ L +l+++i 
  EFC38546.1 402 KMNHSIKILT--SQVFSLGIFLFILSFTIY 429
                 4444444333..334578888888888875 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 3.4
      DUF872  18 qysfsslssvtqrsywlkhPkvkknrk 44 
                 +y++ss + + ++ y +++P++k    
  EFC38546.1 472 KYEYSSDEYSMSLGYNIEEPLIKMHVN 498
                 577777777788888999999987655 PP

>> DUF2371  Uncharacterised conserved protein (DUF2371)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   0.00011      0.33      81     128 ..     384     431 ..     335     433 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00011
     DUF2371  81 aessseklgllarfleqylysdklkvlGPlimGiGiflfiCanavLhe 128
                 + ++ e l++la+ +++y   + +k+l   +  +Giflfi + ++  e
  EFC38546.1 384 NLTNDEILAILAHEIHHYKMNHSIKILTSQVFSLGIFLFILSFTIYNE 431
                 445566678999999*************************99988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (547 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       843  (0.0470188); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.67u 0.35s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 3156.17
//
Query:       EFC38547.1  [L=666]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-30  104.8  11.3      1e-07   31.7   0.2    6.5  6  RRM_1         RNA recognition motif. (a.k.a. RRM, RBD, or RNP
    6.6e-05   22.9   5.1       0.27   11.3   0.0    4.3  4  RRM_3         RNA binding motif
     0.0062   15.5   1.6      0.015   14.2   0.3    2.4  2  tRNA-synt_1c  tRNA synthetases class I (E and Q), catalytic d
  ------ inclusion threshold ------
      0.014   15.4   1.3         10    6.2   0.0    4.4  4  Nup35_RRM_2   Nup53/35/40-type RNA recognition motif
      0.023   14.3   0.7        9.6    5.9   0.3    2.9  2  SET_assoc     Histone lysine methyltransferase SET associated


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.013        48       2      22 ..      92     112 ..      91     123 .. 0.91
   2 !   25.4   0.0   2.6e-09   9.3e-06      30      69 ..     195     234 ..     189     235 .. 0.88
   3 !    9.5   0.0   0.00023      0.82       3      21 ..     266     284 ..     264     310 .. 0.86
   4 !   10.8   0.1   9.3e-05      0.33      33      69 ..     312     348 ..     303     349 .. 0.87
   5 !   25.9   0.1   1.7e-09   6.2e-06       3      60 ..     398     456 ..     396     461 .. 0.90
   6 !   31.7   0.2   2.8e-11     1e-07       3      69 ..     589     657 ..     587     658 .. 0.94

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.013
                 EEESETTTSSHHHHHHHHHTT CS
       RRM_1   2 fVgnLppdvteeeLkelFskf 22 
                  +++Lp++ t +++ e+Fs+f
  EFC38547.1  92 RLRGLPWTSTVQDIAEFFSEF 112
                 5789***************98 PP

  == domain 2  score: 25.4 bits;  conditional E-value: 2.6e-09
                 EEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEE CS
       RRM_1  30 lvrdetgkskgfafVeFeskedAekAlealngkklggrel 69 
                 l+ +  gks+g a+V+Fes+e+ ekA +++++k+lg+r +
  EFC38547.1 195 LMLNYFGKSTGEAYVRFESEEELEKARKTMDKKNLGSRYI 234
                 4555789******************************987 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00023
                 EESETTTSSHHHHHHHHHT CS
       RRM_1   3 VgnLppdvteeeLkelFsk 21 
                 ++n+p+++te+e++++Fs+
  EFC38547.1 266 MRNVPFSATEDEIETFFSG 284
                 79***************97 PP

  == domain 4  score: 10.8 bits;  conditional E-value: 9.3e-05
                 E.TTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEE CS
       RRM_1  33 d.etgkskgfafVeFeskedAekAlealngkklggrel 69 
                 +  +gk +g  fVeF+ ++++ +A +  n++k+++r +
  EFC38547.1 312 NpMNGKRTGEVFVEFTCHDQMLQAAK-RNKEKIRNRYI 348
                 4467999*****************99.9*******987 PP

  == domain 5  score: 25.9 bits;  conditional E-value: 1.7e-09
                 EESETTTSSHHHHHHHHHTTSCE.EEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHT CS
       RRM_1   3 VgnLppdvteeeLkelFskfGpi.ksiklvrdetgkskgfafVeFeskedAekAlealn 60 
                 +++Lp++  e+e+ elF++       i l+  e++ s+g afVeF ++e+ +kAle+ +
  EFC38547.1 398 IEGLPTSFEENEIAELFNGLSLSeAGIHLIFGEDECSTGEAFVEFVNEESFAKALEQND 456
                 89*****************8877589999999***********************9544 PP

  == domain 6  score: 31.7 bits;  conditional E-value: 2.8e-11
                 EESETTTSSHHHHHHHHHTTSCE.EEEEEEEE.TTTSEEEEEEEEESSHHHHHHHHHHHTTEEETTEEE CS
       RRM_1   3 VgnLppdvteeeLkelFskfGpi.ksiklvrd.etgkskgfafVeFeskedAekAlealngkklggrel 69 
                 +++Lp++ te+e+ e+F ++     si+   d ++++ +g+++++F +k +Ae+A ++ n+ ++g+r +
  EFC38547.1 589 MRGLPFSSTEKEIAEFFAGYDFEeDSIRFKMDfKRNRQTGICYIRFRTKTEAERAANERNRCNIGDRYI 657
                 789*****************9996799**********************************99999987 PP

>> RRM_3  RNA binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.37   1.3e+03       2      25 ..      89     112 ..      88     116 .. 0.91
   2 !    7.0   0.1    0.0017       6.1      36      77 ..     203     254 ..     186     273 .. 0.68
   3 ?    2.9   0.4     0.031   1.1e+02       3      74 ..     395     476 ..     394     501 .. 0.64
   4 !   11.3   0.0   7.5e-05      0.27       4      60 ..     587     650 ..     585     660 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.37
                 -EEEEEE-SSS--HHHHHHHCHCC CS
       RRM_3   2 vilklsGlnkelsredikellskl 25 
                 +++ l Gl   ++++di e++s++
  EFC38547.1  89 CVVRLRGLPWTSTVQDIAEFFSEF 112
                 78999****************997 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0017
                 TSSEEEEEESSHHHHHHHHHHHHHC..........-B-CCTSSEEEEE--HH CS
       RRM_3  36 gdkegevrFkedeeakkalekatea..........klkikdaevtlelLeGe 77 
                    e++vrF+++ee +ka + + ++          k +i++ e + ++Le +
  EFC38547.1 203 STGEAYVRFESEEELEKARKTMDKKnlgsryieifKSTIEEMEHSRRVLERN 254
                 55689********977776666555333555555666666666666666544 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.031
                 EEEEEE-SSS--HHHHHHHCHCCS......-ECEEEE-TTSSEEEEEESSHHHHHHHHHHHHHC....-B-CCTSSEEEEE- CS
       RRM_3   3 ilklsGlnkelsredikellsklg......evayvdyekgdkegevrFkedeeakkalekatea....klkikdaevtlelL 74 
                 i+k++Gl      ++i el++ l+      ++ + + e    e+ v F ++e+  kale+   +    + ++ +++ t++++
  EFC38547.1 395 IVKIEGLPTSFEENEIAELFNGLSlseagiHLIFGEDECSTGEAFVEFVNEESFAKALEQNDTTissvDENNVEQQNTIKVI 476
                 8999999999999999999999998666333333334444456679999999955555554444254433333444444444 PP

  == domain 4  score: 11.3 bits;  conditional E-value: 7.5e-05
                 EEEEE-SSS--HHHHHHHCHCCS....-ECE.EEE-TTSSEE..EEEESSHHHHHHHHHHHHHC CS
       RRM_3   4 lklsGlnkelsredikellsklg....evay.vdyekgdkeg..evrFkedeeakkalekatea 60 
                 lk+ Gl   ++ ++i e+++ ++    ++++ +d++++ ++g  ++rF ++ ea++a +++   
  EFC38547.1 587 LKMRGLPFSSTEKEIAEFFAGYDfeedSIRFkMDFKRNRQTGicYIRFRTKTEAERAANERNRC 650
                 78999999999***********999999**989****99996448************9987765 PP

>> tRNA-synt_1c  tRNA synthetases class I (E and Q), catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.3   4.3e-06     0.015      90     137 ..     203     247 ..     162     257 .. 0.84
   2 ?   -2.5   0.0      0.52   1.9e+03     255     294 ..     365     404 ..     319     413 .. 0.55

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 4.3e-06
                   HTTSEEEE-STHHHHHHHHCCSSHSS-TTTTS-HHHHHHHHHHHHHTT CS
  tRNA-synt_1c  90 kkGkAYvcectkeeleeereeqeklgskerdrydeenlklfeeemkkg 137
                   + G AYv ++++eele+ r++  k++    +ry+e + +   eem++ 
    EFC38547.1 203 STGEAYVRFESEEELEKARKTMDKKN--LGSRYIEIFKSTI-EEMEHS 247
                   579****************9966666..899*****99999.888865 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.52
                   TTSSSSTT-TTSCBHHHHHHCTB-HHHHHHHHHHHCCCSS CS
  tRNA-synt_1c 255 ekqvkewddlreallnflrrlGwtpekerelftreeliks 294
                   ++q +++++ +   ++  r  G++  k + +++ e+l +s
    EFC38547.1 365 IQQQQQQNYFPYQHITRPRISGVQNRKSNFIVKIEGLPTS 404
                   4444555555555555555555555555555555555555 PP

>> Nup35_RRM_2  Nup53/35/40-type RNA recognition motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.0    0.0029        10      30      52 ..     198     220 ..     194     220 .. 0.91
   2 ?   -0.5   0.0      0.35   1.2e+03      38      53 .]     437     452 ..     432     452 .. 0.89
   3 ?   -2.1   0.0       1.1   4.1e+03      15      41 ..     545     571 ..     539     572 .. 0.76
   4 ?    3.9   0.1     0.015        55      34      52 ..     625     643 ..     585     644 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0029
  Nup35_RRM_2  30 hyvpkevsvmyvkfesekdaekA 52 
                   y++k++  +yv+fese + ekA
   EFC38547.1 198 NYFGKSTGEAYVRFESEEELEKA 220
                  5999999************9998 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.35
  Nup35_RRM_2  38 vmyvkfesekdaekAL 53 
                   ++v+f +e + +kAL
   EFC38547.1 437 EAFVEFVNEESFAKAL 452
                  589************8 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.1
  Nup35_RRM_2  15 elVlehFasfGeIvkhyvpkevsvmyv 41 
                  ++V ++F++ G+  + + ++++ + +v
   EFC38547.1 545 YYVNPYFQQQGQSFRNNLDPNTDSTIV 571
                  78999***9998777777777666665 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.015
  Nup35_RRM_2  34 kevsvmyvkfesekdaekA 52 
                  +++ + y++f+++ +ae+A
   EFC38547.1 625 RQTGICYIRFRTKTEAERA 643
                  567789***********99 PP

>> SET_assoc  Histone lysine methyltransferase SET associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0    0.0036        13      37      59 ..     208     230 ..     204     236 .. 0.91
   2 ?    5.9   0.3    0.0027       9.6      33      55 ..     626     649 ..     616     657 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0036
   SET_assoc  37 YivFndskeAerCfraedgtklf 59 
                 Y+ F++ +e e++ +++d++ l 
  EFC38547.1 208 YVRFESEEELEKARKTMDKKNLG 230
                 9******************9876 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0027
   SET_assoc  33 ktGy.YivFndskeAerCfraedg 55 
                 +tG+ Yi F+++ eAer+ ++ ++
  EFC38547.1 626 QTGIcYIRFRTKTEAERAANERNR 649
                 56655*************998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (666 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1872  (0.104412); expected 358.6 (0.02)
Passed bias filter:                      607  (0.0338558); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.76u 0.32s 00:00:01.08 Elapsed: 00:00:00.51
# Mc/sec: 3954.71
//
Query:       EFC38548.1  [L=189]
Description: hypothetical protein NAEGRDRAFT_56340 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-61  205.8   2.6    4.2e-61  205.6   2.6    1.0  1  GMP_PDE_delta  GMP-PDE, delta subunit


Domain annotation for each model (and alignments):
>> GMP_PDE_delta  GMP-PDE, delta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  205.6   2.6   2.3e-65   4.2e-61       2     157 .]      27     183 ..      26     183 .. 0.99

  Alignments for each domain:
  == domain 1  score: 205.6 bits;  conditional E-value: 2.3e-65
  GMP_PDE_delta   2 aniygieftrfkirdlesgkvlfeiakessseeeeeeeeeeeenagrevryqftpkflklktvgatveFsvgekpvknfrlierhyfkdkllksfd 97 
                    an+ gi+f +fkir+++sg+vlf+++ e++++e  ++ ++ +e++ r ++y+f++++l+ k +g+t++F+vg kpvknfr+ierhyfk+kllk fd
     EFC38548.1  27 ANTVGIQFLEFKIRNCDSGEVLFHTSAEETAKELLKQGTTIDEDSLRSINYKFDKAMLRSKGIGTTLTFKVGPKPVKNFRMIERHYFKEKLLKGFD 122
                    899********************************************************************************************* PP

  GMP_PDE_delta  98 FefgFciPnskNtwehiyeapelseelveemiaspfetksdsfyfv.dnklvmhnkaeyaY 157
                    F+f FciPns+Ntwe iy++pel+ee + e+ +sp+++ksdsfyfv d++++mhnka yaY
     EFC38548.1 123 FNFKFCIPNSQNTWECIYSMPELTEEEIIEIENSPYQVKSDSFYFVnDDEMIMHNKAAYAY 183
                    **********************************************8899**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       522  (0.0291148); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 1120.20
//
Query:       EFC38549.1  [L=1167]
Description: hypothetical protein NAEGRDRAFT_73596 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.8e-33  115.7   6.1    8.8e-33  114.1   0.2    3.3  3  DUF4821      Domain of unknown function (DUF4821)
    0.00096   18.5   0.0       0.18   11.0   0.0    2.5  3  Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase


Domain annotation for each model (and alignments):
>> DUF4821  Domain of unknown function (DUF4821)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  114.1   0.2   9.8e-37   8.8e-33       2     251 ..      14     260 ..      13     265 .. 0.84
   2 ?    1.4   0.4     0.022     2e+02      82     148 ..     283     350 ..     268     380 .. 0.74
   3 ?    1.0   0.0     0.029   2.6e+02     228     257 ..     428     457 ..     416     462 .. 0.88

  Alignments for each domain:
  == domain 1  score: 114.1 bits;  conditional E-value: 9.8e-37
     DUF4821   2 vRraeldDaeeieklissstek...lFgrvnvlklleksrLavtllnekeeilafavfsdyPnielldeaeWeawleekfdldkpitplntLFlnffva 97 
                 +Rra++d+a++i+k is+++      Fg+ n+ +++e+ ++++++  ++++  +fa+f   P+   ld +++ ++l        p+++ nt+++ ++ +
  EFC38549.1  14 IRRAKSDEAPNIQKYISENSFLltkRFGNYNLKTIIETGYISIVAEGDQGQYQGFASFEFEPSDT-LDVEKYFSYL--------PLNVRNTIWIRLVHF 103
                 8*****************7644444*************************************855.5666665555........66666********** PP

     DUF4821  98 kseyaeaalkeilrevFaalpelefillvl.ppdvelepaleelFekleklgtskypkefslaknnkqevyickreal...lpklhiRkArvEDhDDlv 192
                 +  + e+ l e+l+++F +++e+++i++   +++v+    + + F+     +++   +++ ++++ ++++++c+r++l   +++l+iR+A+vED+DD++
  EFC38549.1 104 EPLFGETVLIEMLNSIFITFSEVDNICFQPvRSNVQSGIDFFSQFSFF---KQEIG-SDVLVKSDTEKCIFVCHRDNLgrgVKRLSIRQAVVEDNDDII 198
                 ***************************986345555555555555544...44433.44455677999********9655589**************** PP

     DUF4821 193 eiferqseelreef.GdyflaelieaqdeenkaiVaeve..gkavGllslstdvdvklLqen 251
                 +++ + +++ + +  G+yfla+l+ +q++++k++ a+++  g +vG++ ++t++d++   + 
  EFC38549.1 199 PLLSSCENVTSYKTeGEYFLANLLFEQNDSKKILLATDTesGDIVGVMYITTELDIRQILSD 260
                 *****9999986655**************999998888889***************976655 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.022
     DUF4821  82 kpitplntLFlnffvakseyaeaalkeilrevFaalpelefillvl..ppdvelepaleelFekleklg 148
                 + +   n++ +++f +++ey+ +    +lr++F+a++e +++++ +  + +++ e  l + F  +e ++
  EFC38549.1 283 NMVYHSNAFEIKLFYIQEEYKFR-SIDLLRAAFKAFQESKYCIVGIkfEDHSKSEHPLLKQFIYIEPTQ 350
                 556667778889999999**999.899**************9997755566667777777777664443 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.029
     DUF4821 228 evegkavGllslstdvdvklLqenFeLepf 257
                 e +++++G+ ++ t+v+  lL+++F++ ++
  EFC38549.1 428 EGRNEIIGIAVVDTQVNEFLLRRHFDFTEY 457
                 4557899*******************9998 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.0    0.0017        15     133     235 ..     580     695 ..     547     726 .. 0.68
   2 !   11.0   0.0     2e-05      0.18     181     279 ..     797     914 ..     742     929 .. 0.82
   3 ?   -3.4   0.1      0.49   4.4e+03      44      93 ..    1086    1133 ..    1072    1140 .. 0.63

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0017
                  HHHHCCSS-T..SEEEEES-SHHHHHHHHHHHHHT-.............EEEEEESSSSSS.TTS-HHHHHHHHHHHHHT.TEEEEESCEEEEEEETT CS
                  xxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxx.............xxxxxxxxxxxx.xxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 133 aealklkllp..krivvvGgGyiGvElAaalaklgk.............evtlveardrll.raldkelsaaleealeke.Gvevklgtsvkeidgng 213
                   ++l++++++   rivv+Gg+ +++ +  +l+   +             +vt     ++++   +d+e+ ++    +    ++ ++ + + ++i++ +
   EFC38549.1 580 RRYLSEEKTEifSRIVVIGGSKTALSFIKELSANSSlffnniivvspegDVT---KSPEFYaDDTDEEFNNRELLNMISLpNIYFV-KDKLEDIERVN 673
                  4556666666999************999887554444555444455544444...6666666666666666666655555566666.66666666666 PP

                  EEEEEEETTSCEEEESEEEE-S CS
                  xxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 214 eklevvledgeeidadlvvvav 235
                  +++ + +++ + i +d +++++
   EFC38549.1 674 KSVLLYENQSSFITYDILLLCT 695
                  5333333333336666666665 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 2e-05
                  S-HHHHHHHHHHHHHTTEEEEESCEEEEEEETTE..EEE..EEETTSCE..........EEESEEEE-S-EEES-HHCS..HCCT-EEEETTEEE--T CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxx..xxxxxxxx..........xxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 181 ldkelsaaleealekeGvevklgtsvkeidgnge..kle..vvledgee..........idadlvvvavGvrpstelle..eklglelderggivvde 262
                   ++e++++l + le  G +   + + +++ +++e   ++  +  ++++e          id++l + +     ++ +l   +++ l    +g++ vd 
   EFC38549.1 797 ENEEIEDRLDHILEVAGLKYFSQYTLEDFASDEEgnLVRiyLSPNEEKEekkkhakmveIDCSLFINCHSKDVDDGILStvNRQSLVF--DGRLIVDT 892
                  5689999999999999999999999999999999984445444444444567899999999999****99999999998877777777..******** PP

                  TSBESSTTEEE-GGGC.....T CS
                  xxxxxxxxxxxxxxxx.....x RF
  Pyr_redox_2 263 flrtnvpgiyaiGDva.....g 279
                  + rt++++iy +G +a      
   EFC38549.1 893 QFRTTDTSIYSAGPMAkfsrrF 914
                  *************999665553 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 0.49
                   CHHHHHHHHHHHHHHHHHCHHHHCCCCHCCTCEEEEESCEEEEETEEECT CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2   44 kallgvaedaeiasevvkklnqgielllgeevvkidpgkkkvklekkkeg 93  
                   k+ll+ +++   + ev++++  +++l  ++e++++dp k ++k+ek+++ 
   EFC38549.1 1086 KKLLNEEDNIGNINEVCNEIA-ELILHGESEIFTVDPTK-TIKVEKEVTR 1133
                   444444444444445555554.34445556799999999.9999887764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1167 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.31s 00:00:01.08 Elapsed: 00:00:00.50
# Mc/sec: 7044.38
//
Query:       EFC38550.1  [L=135]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (135 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       547  (0.0305092); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 848.55
//
Query:       EFC38551.1  [L=538]
Description: hypothetical protein NAEGRDRAFT_81548 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.048   14.3   0.2      0.048   14.3   0.2    6.5  5  SlyX           SlyX
      0.056   12.3  66.4      0.082   11.8   6.5    3.3  3  Spc7           Spc7 kinetochore protein
        1.3    9.5   8.7        1.6    9.2   0.0    4.6  5  LPP            Lipoprotein leucine-zipper
        4.4    7.8  70.7      0.081   13.4  11.9    4.6  3  APG6_N         Apg6 coiled-coil region
        7.4    6.3   5.4        1.1    8.9   0.1    2.4  2  DUF2937        Protein of unknown function (DUF2937)


Domain annotation for each model (and alignments):
>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0    0.0055        20      25      56 ..      48      79 ..      39      84 .. 0.86
   2 ?   14.3   0.2   1.4e-05     0.048      17      55 ..      87     125 ..      83     132 .. 0.88
   3 ?   -0.5   0.3      0.54   1.9e+03      16      16 ..     173     173 ..     141     218 .. 0.58
   4 ?   -2.0  11.7       1.7   5.9e+03      17      58 ..     220     261 ..     212     277 .. 0.79
   5 ?    3.5   0.3     0.031   1.1e+02      10      55 ..     327     372 ..     318     380 .. 0.67

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0055
                HHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXX CS
        SlyX 25 vvaeqqqqidrlqrqlrllaerlkeleessga 56
                ++ +q+ +id++++  +ll+e +++l  + ++
  EFC38551.1 48 ALSKQRFTIDKIKKDNDLLRETIANLTRNVNT 79
                6889*******************999887665 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1.4e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXX CS
        SlyX  17 dtieeLndvvaeqqqqidrlqrqlrllaerlkeleessg 55 
                 + i++Lndv+++   +i++ +r+++ l+e++k+ +++ +
  EFC38551.1  87 KKINKLNDVIYNITLKIQEEKRKVENLEEHFKDTSNRIE 125
                 5799***************************99988755 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.54
                 H CS
        SlyX  16 e 16 
                  
  EFC38551.1 173 R 173
                 1 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.7
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXX CS
        SlyX  17 dtieeLndvvaeqqqqidrlqrqlrllaerlkeleessgase 58 
                 +++ee  +v  e+q++i++++++ ++l + lke+e+ +++ +
  EFC38551.1 220 QALEEQKQVKDEHQKEIEKIEEEREQLDRLLKEAEKVTEKLQ 261
                 568888899999999999999999999999888887766544 PP

  == domain 5  score: 3.5 bits;  conditional E-value: 0.031
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXX CS
        SlyX  10 iklafqedtieeLndvvaeqqqqidrlqrqlrllaerlkeleessg 55 
                 ++ +  ed+  +L   v e + +i++l++ + +++e++k+ + +  
  EFC38551.1 327 EHFSQSEDQNFSLFTYVNELNSEIEKLEENIVEIEEEIKKFKGEGV 372
                 5555556666666667778888888888888888888877766655 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8  12.9   4.6e-05      0.16     139     269 ..      26     156 ..      23     164 .. 0.84
   2 ?    1.0  31.8     0.043   1.5e+02     150     290 ..     171     315 ..     157     323 .. 0.71
   3 ?   11.8   6.5   2.3e-05     0.082     142     239 ..     323     420 ..     322     425 .. 0.94

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 4.6e-05
        Spc7 139 gLkegleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesid.keeLeelreelaelkaeieekkkelaelqeqleeleeki 236
                 +Lk++ ++n++++++ k++ +   ++     +++++  + l+e++++l + ++  es+   +++++l + + ++  +i+e k+++++l+e  ++ +++i
  EFC38551.1  26 SLKKTQKKNVNTVKKVKNMSDGALSKQRFTIDKIKKDNDLLRETIANLTRNVNTSESVAlGKKINKLNDVIYNITLKIQEEKRKVENLEEHFKDTSNRI 124
                 56677777777777766666666666667778899999*********************99************************************** PP

        Spc7 237 eelkeqkseleeeiaeaervleeckgwsesevs 269
                 ee++ ++s ++   +e++r++e++ ++ e+ ++
  EFC38551.1 125 EEARIERSGVNVS-KESNRLVEKQIKVLENRLD 156
                 *****99999876.5588888888777666665 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.043
        Spc7 150 gleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqk.sele 247
                  l+++ e+L k++  +d++++++e+e +e ++e++k+ e +++  +   + Lee ++  +e+++eie+ ++e ++l + l+e e+  e+l+++  ++ e
  EFC38551.1 171 VLRDQIENLRKERVVFDSIYKKMEKELQEKKKEMAKIIELSNSAYEERGQALEEQKQVKDEHQKEIEKIEEEREQLDRLLKEAEKVTEKLQQRElERRE 269
                 466777889999999999999999999999999999999888888888888988888888888888776666666655555555555554443202233 PP

        Spc7 248 eeiaea...ervleeckgwsesevsrlkeevkaleeltgwkivsls 290
                  ei+ea   +r ++ + +ws+s v++  + +++  ++++ ++ +++
  EFC38551.1 270 REIQEAadlDRKRMLKSSWSNSGVKARATDMNEKRKQYEERFSKIE 315
                 4455541116777788899999999988888887777777777766 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 2.3e-05
        Spc7 142 egleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieel 239
                 ++l e++++ e+++  L    +el++  ++lee+  e+eee++k + +  + es  k+ L  ++e+++e +++ +  ++++++  + le ++  ie++
  EFC38551.1 323 DELIEHFSQSEDQNFSLFTYVNELNSEIEKLEENIVEIEEEIKKFKGEGVNSESQRKKVLSDIQEKINETNSKTDLYQRKYENSLKTLEIISRGIETI 420
                 578999*********************************************9*******************************999999999988876 PP

>> LPP  Lipoprotein leucine-zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.67   2.4e+03       2      27 ..      56      81 ..      55      84 .. 0.82
   2 ?    2.0   0.1     0.077   2.8e+02       5      33 ..      99     127 ..      84     131 .. 0.73
   3 ?   -1.6   0.1       1.1   3.8e+03      12      36 ..     172     203 ..     170     206 .. 0.64
   4 ?   -2.8   0.3       2.4   8.7e+03       7      11 ..     244     248 ..     224     264 .. 0.52
   5 ?    9.2   0.0   0.00045       1.6       9      36 ..     343     370 ..     338     372 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.67
         LPP  2 ldeLssqVsqLkskvdqlssdvnsak 27
                +d++ ++   L + +++l+ +vn ++
  EFC38551.1 56 IDKIKKDNDLLRETIANLTRNVNTSE 81
                68888888889999999999999765 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.077
         LPP   5 LssqVsqLkskvdqlssdvnsakaaaqaa 33 
                 ++  +++ k+kv++l++  +++++ +++a
  EFC38551.1  99 ITLKIQEEKRKVENLEEHFKDTSNRIEEA 127
                 55567777888888888888877777776 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 1.1
         LPP  12 Lkskvdqlssd.......vnsakaaaqaakeE 36 
                 L +++++l ++        +++++++q+ k+E
  EFC38551.1 172 LRDQIENLRKErvvfdsiYKKMEKELQEKKKE 203
                 56666666666555555577777777777666 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 2.4
         LPP   7 sqVsq 11 
                 +q+ +
  EFC38551.1 244 EQLDR 248
                 23333 PP

  == domain 5  score: 9.2 bits;  conditional E-value: 0.00045
         LPP   9 VsqLkskvdqlssdvnsakaaaqaakeE 36 
                 V++L+s++++l++++ ++++++++ k E
  EFC38551.1 343 VNELNSEIEKLEENIVEIEEEIKKFKGE 370
                 8889999999999999999888888876 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2  13.8      0.38   1.4e+03      21      91 ..     103     183 ..       7     188 .. 0.86
   2 ?    4.2  29.1     0.017        60      28     106 ..     190     272 ..     187     291 .. 0.81
   3 ?   13.4  11.9   2.3e-05     0.081      14     123 ..     293     396 ..     290     410 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.38
      APG6_N  21 aekerdaYeeflkklkkekkeeek..........qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeel 91 
                  ++e+++ e+ ++++k++++  e+          ++e+ +  e++++ le+  +++l + +e  +e++ l++++++l++e 
  EFC38551.1 103 IQEEKRKVENLEEHFKDTSNRIEEariersgvnvSKESNRLVEKQIKVLENRLDKALVKFNESLTENKVLRDQIENLRKER 183
                 344555555555555555555544677999999999999999999******************************999985 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.017
      APG6_N  28 Yeeflkklkkekkeeek....qdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreyn 106
                 Y++ +k+l+++kke  k    +++  ee  + le+ ++ ++e ++e++++e+ere+l++ l+++e+ +e+l++ e +  ++  
  EFC38551.1 190 YKKMEKELQEKKKEMAKiielSNSAYEERGQALEEQKQVKDEHQKEIEKIEEEREQLDRLLKEAEKVTEKLQQRELERREREI 272
                 99999****9988877698887888888888899999999999*****************************99977654443 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 2.3e-05
      APG6_N  14 ldkqleqaekerdaYeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreynelqlel 112
                 ++ +  +++++r++Yee  +k+++ + +      +++el e +++ e++  +l++  +el +e e+le+ + ++eee ++ + e  +  +++++   + 
  EFC38551.1 293 VKARATDMNEKRKQYEERFSKIEEATGK------NIDELIEHFSQSEDQNFSLFTYVNELNSEIEKLEENIVEIEEEIKKFKGEGVNSESQRKKVLSDI 385
                 677889999**************99544......899********************************************998777766666666666 PP

      APG6_N 113 leleeeldsle 123
                 +e+ +e +s +
  EFC38551.1 386 QEKINETNSKT 396
                 66666655543 PP

>> DUF2937  Protein of unknown function (DUF2937)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   2.2       1.7   6.1e+03      52      94 ..     214     254 ..     190     290 .. 0.55
   2 ?    8.9   0.1   0.00031       1.1      43      73 ..     309     338 ..     293     370 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.7
     DUF2937  52 ffkgdlealiahyrqsedpvvradaesiqalverlerLeqelq 94 
                   + ++ ++++  +q +d+  +++ e+i++  e+l+rL +e +
  EFC38551.1 214 AYE-ERGQALEEQKQVKDE-HQKEIEKIEEEREQLDRLLKEAE 254
                 444.455555555555543.23344444444444444433333 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00031
     DUF2937  43 agfqatAkrffkgdlealiahyrqsedpvvr 73 
                 + f++  ++++k ++++li+h++qsed+ ++
  EFC38551.1 309 ERFSKIEEATGK-NIDELIEHFSQSEDQNFS 338
                 568888889999.**************9885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4252  (0.237158); expected 358.6 (0.02)
Passed bias filter:                      689  (0.0384294); expected 358.6 (0.02)
Passed Vit filter:                       186  (0.0103743); expected 17.9 (0.001)
Passed Fwd filter:                        79  (0.00440627); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.75u 0.35s 00:00:02.10 Elapsed: 00:00:00.61
# Mc/sec: 2657.39
//
Query:       EFC38552.1  [L=454]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.8e-73  245.3   0.7    5.8e-73  244.7   0.7    1.3  1  SRP54         SRP54-type protein, GTPase domain
    1.3e-28   99.5   3.2    1.3e-28   99.5   3.2    2.3  3  SRP_SPB       Signal peptide binding domain
    1.1e-13   51.1   1.5    3.4e-13   49.6   0.2    2.4  2  SRP54_N       SRP54-type protein, helical bundle domain
    2.6e-05   24.7   0.1    6.9e-05   23.3   0.1    1.7  1  AAA_17        AAA domain
    8.6e-05   22.2   0.6    0.00072   19.2   0.6    2.3  1  cobW          CobW/HypB/UreG, nucleotide-binding domain
     0.0006   19.6   0.0      0.001   18.8   0.0    1.4  1  AAA_30        AAA domain
    0.00072   19.6   0.0     0.0023   18.0   0.0    1.9  1  CbiA          CobQ/CobB/MinD/ParA nucleotide binding domain
     0.0071   16.6   0.0      0.026   14.8   0.0    2.0  1  AAA_22        AAA domain
  ------ inclusion threshold ------
      0.019   13.8   0.0       0.04   12.7   0.0    1.5  1  Fe-ADH        Iron-containing alcohol dehydrogenase
      0.027   14.5   0.1       0.06   13.4   0.1    1.6  1  ResIII        Type III restriction enzyme, res subunit
      0.045   13.9   0.0      0.089   13.0   0.0    1.5  1  AAA_33        AAA domain
       0.05   13.7   0.3       0.15   12.1   0.3    1.9  1  MMR_HSR1      50S ribosome-binding GTPase
      0.055   11.2   0.1      0.082   10.6   0.1    1.2  1  CobN-Mg_chel  CobN/Magnesium Chelatase
      0.062   12.7   1.0        0.1   12.0   1.0    1.2  1  DUF373        Domain of unknown function (DUF373)
       0.18   11.2   0.7        1.3    8.3   0.7    2.2  1  Herpes_V23    Herpesvirus VP23 like capsid protein


Domain annotation for each model (and alignments):
>> SRP54  SRP54-type protein, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  244.7   0.7   4.8e-76   5.8e-73       7     196 .]      87     276 ..      81     276 .. 0.99

  Alignments for each domain:
  == domain 1  score: 244.7 bits;  conditional E-value: 4.8e-76
                 EESTTSSHHHHHHHHHHHHHHTTS-EEEEEESTSSTTHHHHHHHHHHHTTEEEEESSTTSCHHHHHHHHHHHHHHTTSSEEEEEE--SSTTHHHHHHHH CS
       SRP54   7 vGlqGaGKTttlaKLaallkkegkkvllvaaDtfRaaAveQLktlaeklgvpvikkkeeadpaavakeavekakeekidvvlvDTaGrlqndkelmeel 105
                 +GlqGaGKTtt++K a++++k+g + +lv+aDtfRa+A+eQL+++a k+++ +++ + e++p+++ak++ve++k+ek++v++vDT+Gr+ ++++l+ee+
  EFC38552.1  87 IGLQGAGKTTTCTKYARYYQKKGFRSALVCADTFRAGALEQLRQNAAKVQIAFYGDEYETNPVKIAKDGVEQFKNEKYEVIIVDTSGRHMQEESLFEEM 185
                 7************************************************************************************************** PP

                 HHHHHHHSSSEEEEEEETTBHTHHHHHHHHHHHHSSCSEEEEESTTSSSSTTHHHHHHHHHTS-EEEEE-SSSTTGEEE--HHHHHHHHHT CS
       SRP54 106 kkikkvvkpdevllvldattgqeavkqakaFkeavgitgviltklDgdakgGaalsiaaelklPikfigvGekiedleefdperlvsrllg 196
                 ++++++v+pdev++v+d+++gq++ +qa aFk++v++++vi+tklDg+akgG+als++a++k+Pi fig+Ge  +++++f++e++vsrllg
  EFC38552.1 186 EQVSQAVNPDEVIFVMDSSIGQSVKEQAAAFKSRVSVGSVIVTKLDGHAKGGGALSAVAATKSPITFIGTGEDFDNFQQFNAESFVSRLLG 276
                 *****************************************************************************************95 PP

>> SRP_SPB  Signal peptide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       7.7   9.2e+03      78      97 ..     172     190 ..     156     219 .. 0.67
   2 !   99.5   3.2   1.1e-31   1.3e-28       2      99 .]     308     411 ..     307     411 .. 0.94
   3 ?   -1.9   0.1       4.5   5.4e+03      11      30 ..     419     438 ..     417     446 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 7.7
                 TTS-HHHHHHHHHHHHHHHH CS
     SRP_SPB  78 sGtsvqevnellkqfeqmkk 97 
                 sG+++qe + l++++eq+++
  EFC38552.1 172 SGRHMQE-ESLFEEMEQVSQ 190
                 4444444.344444444443 PP

  == domain 2  score: 99.5 bits;  conditional E-value: 1.1e-31
                 SCTHHHHHHHHHHHCCCCCCHHHHCCC........H...CCCCCHHHHHHHHHTTSBHHHHHSGCG-......HHHHHHHHHHTTS-HHHHHHHHHHHH CS
     SRP_SPB   2 ftlrdlleqlqqikkmGplskllsmiPgmsae...akaeeeaekklkrieaiidSMTkeErdspekllk....esRkrRiArGsGtsvqevnellkqfe 93 
                 +t+rd++e++++i+kmGpls+++smiPg+s++   +++e+e++ +lk++ +i+dSM + E+d ++ + k    +sR++RiArGsG++ ++v+ell+qf+
  EFC38552.1 308 YTIRDMREHFTSIMKMGPLSQVMSMIPGFSEQllpKGSEQESNARLKKYLTIMDSMNDTEMDCTD-ITKlpnmQSRIMRIARGSGRTPKDVQELLEQFK 405
                 79**************************9999*998888999***********************.66556556************************* PP

                 HHHHHT CS
     SRP_SPB  94 qmkkmm 99 
                  +++m+
  EFC38552.1 406 VFQSMI 411
                 ***995 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 4.5
                 HHHHHCCCCCCHHHHCCC.. CS
     SRP_SPB  11 lqqikkmGplskllsmiPgm 30 
                 l+++k+  +l+kl +++P +
  EFC38552.1 419 LANMKSPKDLQKLSKNLPNT 438
                 67889999999999999975 PP

>> SRP54_N  SRP54-type protein, helical bundle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.6   0.2   2.8e-16   3.4e-13       1      75 []       6      83 ..       6      83 .. 0.95
   2 ?   -0.6   0.1       1.3   1.5e+03      41      70 ..     404     431 ..     393     434 .. 0.81

  Alignments for each domain:
  == domain 1  score: 49.6 bits;  conditional E-value: 2.8e-16
                HHHHHHHHHHHHCCSSCGHHHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHCTTS....S-HHHHHHHHHHHHH CS
     SRP54_N  1 LgkklnsalkklsgkskideedleealkeleeaLleaDVgvkvvkklienvkkkavgekk....lkpkqqvkkivkdeL 75
                Lg+++++al+ ++++ +id++++ e+lke+ ++L+ aDV+++ v +l++ +k   +  +k    ++++ ++k +v++eL
  EFC38552.1  6 LGSRITTALRTINSQAVIDDAAISELLKEIGNSLMAADVNIQQVIQLRNGIKA-GLDFEKlpkgINRRNHIKAVVYQEL 83
                89*************************************************77.7777778999*************98 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.3
                 HHHHHHHHHHHHHHHHCTTSS-HHHHHHHH CS
     SRP54_N  41 vkvvkklienvkkkavgekklkpkqqvkki 70 
                 +kv +++i +vk+  ++  ++k++++++k+
  EFC38552.1 404 FKVFQSMIGRVKD--LNLANMKSPKDLQKL 431
                 6788889999955..555789999999986 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.1   5.8e-08   6.9e-05       1     110 [.      87     202 ..      87     219 .. 0.72

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 5.8e-08
                 EE-TTSSHHHHHHHHHHHH...TEE.EEEHHHHHHHHHHTTTSHSSHHHHC.....TSHHHHHHHHHHHHHHHHHHHHHSSEEEEEE-SEEEETTEEEE CS
      AAA_17   1 lGgPGsGKgtqceklveky...gft.hlsaGdllreeakrgglakardemr.....klpleekkelqkeaaekiaeeakkkgvlvdghprikeqagfld 90 
                 +G+ G+GK+t c k ++ y   gf   l   d +r+ a ++   ++  +++     ++++    ++ k   e+ ++e k + ++vd+  r  +++ +++
  EFC38552.1  87 IGLQGAGKTTTCTKYARYYqkkGFRsALVCADTFRAGALEQLR-QNAAKVQiafygDEYETNPVKIAKDGVEQFKNE-KYEVIIVDTSGRHMQEESLFE 183
                 599*************988555665246778888877655533.333333333444555555666666666666665.56789*******999999999 PP

                 SSHHHHHHHH..SEEEEEE- CS
      AAA_17  91 glpkevleelkpdaiillea 110
                 ++++ v + ++pd +i++ +
  EFC38552.1 184 EMEQ-VSQAVNPDEVIFVMD 202
                 9995.9********999765 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.6     6e-07   0.00072       7     152 ..      88     232 ..      86     248 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 6e-07
                 ESTTCCHHHHHHHHH..CT--SS-EEEEESS-SSCHCCCCCCHCCCT.EEEETTTTECCH.CTT-HHHHHHHHHHHHTT-SEEEEEECTTTTHHHHHTT CS
        cobW   7 GflGsGKTtLlnhll..enraglklavivNefgevsiDaellretgveivelenGciCct.lredllkelealeereerldviliEttGlaePapvaft 102
                 G  G+GKTt  +++    +++g + a++  +    +  ++l +++++  + +  G    t   + +   +e++++++  ++vi++ t+G     +++f+
  EFC38552.1  88 GLQGAGKTTTCTKYAryYQKKGFRSALVCADTFRAGALEQLRQNAAKVQIAF-YGDEYETnPVKIAKDGVEQFKNEK--YEVIIVDTSGRHMQEESLFE 183
                 6679999999999998878899999999999886666555554443323333.343333324555566667776666..9*********6666666577 PP

                 .SHHHHHCCCECEEEEEEETTTH.CCHCCHHHHHHHHHHTSSEEEEE-HHH CS
        cobW 103 .eeelksdltldavvavvDaknleaeeekieekaedqlaaadllvlnKtDl 152
                   e+++++++ d v++v+D+  + ++ ++++  +++ + + +++ ++K D 
  EFC38552.1 184 eMEQVSQAVNPDEVIFVMDS-SIGQSVKEQAAAFKSRVSVGSVI-VTKLDG 232
                 699*****************.56688899999999999998765.678886 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   8.7e-07     0.001      20     133 ..      83     211 ..      72     231 .. 0.68

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 8.7e-07
      AAA_30  20 vavltGpAGtGKttalkalreaweaaggrvi.glAptgkaAkvLaeelgieastiakllkrlk.............grarlepgtllivDEagmv.... 100
                 + +  G  G+GKtt+ +++++ ++++g+r + ++A t + A +L+ +l  +a+ ++   +  +             ++ + e+ +++ivD +g      
  EFC38552.1  83 LFFEIGLQGAGKTTTCTKYARYYQKKGFRSAlVCADTFR-AGALE-QLRQNAAKVQIAFYGDEyetnpvkiakdgvEQFKNEKYEVIIVDTSGRHmqee 179
                 55667999******************9666615555555.56666.45556666666665555668888899997755566666******999553333 PP

      AAA_30 101 .dtkqlaallkaaekagakvilvGDerQlasVea 133
                   +++++++ +a++    +vi+v D    +sV++
  EFC38552.1 180 sLFEEMEQVSQAVNP--DEVIFVMDSSIGQSVKE 211
                 223344444444433..78888888777777765 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   1.9e-06    0.0023       9      87 ..      91     233 ..      86     323 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.9e-06
                 TSSHHHHHHHHHHHHHHTT--EEEEEEEESSCCCCHHTTEB-HHHH..................................................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................................................... RF
        CbiA   9 GvGKTtlaanLaralarrglrVllvDaDpqannlaileglendiep..................................................... 54 
                 G+GKTt++++ ar+ +++g+r +lv aD+ +          +++++                                                     
  EFC38552.1  91 GAGKTTTCTKYARYYQKKGFRSALVCADTFRAG------ALEQLRQnaakvqiafygdeyetnpvkiakdgveqfknekyeviivdtsgrhmqeeslfe 183
                 99************************9998443......333333334447777777777777788888888888888888888888888877777777 PP

                 .....................CCHCCCHHHHHHCHCHHHH..EEEEEEEEESS. CS
                 .....................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        CbiA  55 .....................dlkrllellealgkkkalllkiagvvlnrvdge 87 
                                           ++++++    ++  + + +v++++ dg 
  EFC38552.1 184 emeqvsqavnpdevifvmdssI----GQSVKEQAAAFKSRVSVGSVIVTKLDGH 233
                 7777777777777777764431....3333333333333355555555555554 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   2.1e-05     0.026      11      91 ..      87     194 ..      80     204 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.1e-05
      AAA_22  11 tGesGtGKTtllrrlleqldeeakaee...................erpevvfvtlpsstsskdllrellralglelka........erlsseelleal 82 
                 +G  G+GKTt++ ++++ +++  +                      ++++++f+    +t++ +++++ ++++++e+ +        +  ++e l+e +
  EFC38552.1  87 IGLQGAGKTTTCTKYARYYQKKGFRSAlvcadtfragaleqlrqnaAKVQIAFYGDEYETNPVKIAKDGVEQFKNEKYEviivdtsgRHMQEESLFEEM 185
                 7999**************987666666999999999999999988777777788888888999999999999999999999999999899999999999 PP

      AAA_22  83 eqalrarav 91 
                 eq ++a   
  EFC38552.1 186 EQVSQAVNP 194
                 999888766 PP

>> Fe-ADH  Iron-containing alcohol dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   3.4e-05      0.04      13      86 ..     100     168 ..      89     169 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.4e-05
                 GHHHHHTTT-..EEEEEEEHHHH.HH.THHHHHHHHHCTT-EEEE.EEE-S---HHHHHHHHTTS-TT.--EEE CS
      Fe-ADH  13 elgellkklgakralivtdkgslkksglldkvlesleeagievtvfdgvepnptleeveeaaalareegadvvi 86 
                 + +++ +k g+++al+ +d + +   g+l+++++    a+++++ +++  +  +++  +++++++++e+++v+i
  EFC38552.1 100 KYARYYQKKGFRSALVCADTFRA---GALEQLRQNA--AKVQIAFYGDEYETNPVKIAKDGVEQFKNEKYEVII 168
                 445566778999********965...*********9..889999887777777789****************98 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1     5e-05      0.06      33     110 ..      90     184 ..      70     226 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 5e-05
                 TTSTHHHHHHHHHHHH-S.....-EEEEESSH..HHHHHHHHHGGGGTGG........GEEEESSS-B--...................-SEEEEE CS
      ResIII  33 TGtGKTlvaaklierllkkgkeekflflvprk..slleqtleefkkflseayke....igkkvsgdkkka............kekdstnkkilvtt 110
                  G+GKT +++k +++++kkg  + +l+ +++     leq++++ +k++   y +    +  k+ +d+ ++            ++++  + + l+++
  EFC38552.1  90 QGAGKTTTCTKYARYYQKKGF-RSALVCADTFraGALEQLRQNAAKVQIAFYGDeyetNPVKIAKDGVEQfknekyeviivdTSGRHMQEESLFEE 184
                 6***************99966.59999999763367899998885555444433333333333333333311112222233322222222333333 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   7.4e-05     0.089       3      81 ..      85     174 ..      83     206 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 7.4e-05
      AAA_33   3 llvGlpGsGKstlaerl...lkklg..avllssdtlrr.rlfgtdqqsktdytrvldrlyq.....ilnelarkalsagrnvildatnls 81 
                 + +Gl+G+GK+t  +++   ++k g    l+  dt+r  +l+   q+  + ++ +  + y+     i ++ +++   +++ vi+  t  +
  EFC38552.1  85 FEIGLQGAGKTTTCTKYaryYQKKGfrSALVCADTFRAgALEQLRQNAAKVQIAFYGDEYEtnpvkIAKDGVEQFKNEKYEVIIVDTSGR 174
                 669*********988773336666699999*****9997777766666664444333333322222777777777888888777777433 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.3   0.00013      0.15      41      98 ..     159     214 ..      87     229 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00013
                 EEETTEEEEEEECGGCSSHHHHHH.HHHHHHHHHHCTSEEEEEEETT..TTCSHHHHHHHH CS
    MMR_HSR1  41 vklkgkeielvDtpGliegaseek.glgkaflaleeadlillvvdas..eeklkpldeele 98 
                 +k ++ e+++vDt G  ++++e+  ++ +++ +  + d +++v+d+s  +     ++e+ +
  EFC38552.1 159 FKNEKYEVIIVDTSG-RHMQEESLfEEMEQVSQAVNPDEVIFVMDSSigQ----SVKEQAA 214
                 2334578********.553333335444455555556********77432....3333333 PP

>> CobN-Mg_chel  CobN/Magnesium Chelatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   6.8e-05     0.082      62     151 ..     115     214 ..      63     231 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 6.8e-05
                   x..........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  CobN-Mg_chel  62 k..........kakkekaptvgilfyrahllagntavidaliraleerglnvlpvfvssldseaqealeelftkegeekvdalinttsfalvkgpae 148
                              ++ +++a +v i fy  ++ ++  ++ ++ ++++++++++v+ v +s+ + ++++ +ee+ + ++++++d +i ++  ++ ++ +e
    EFC38552.1 115 VcadtfragalEQLRQNAAKVQIAFYGDEYETNPVKIAKDGVEQFKNEKYEVIIVDTSGRHMQEESLFEEMEQVSQAVNPDEVIFVMDSSIGQSVKE 211
                   0344444566688899***************************************999954555556666666777899999999988888766654 PP

                   xxx RF
  CobN-Mg_chel 149 eee 151
                   +++
    EFC38552.1 212 QAA 214
                   444 PP

>> DUF373  Domain of unknown function (DUF373)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   1.0   8.4e-05       0.1      62     113 ..     160     209 ..     147     229 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 8.4e-05
      DUF373  62 egedvevavvtGdekvgveadrkiaeqldevlskleadsaivVsDGaeDesv 113
                 ++e+ ev++v  + ++    ++++ e++++v +++++d++i+V+D++  +sv
  EFC38552.1 160 KNEKYEVIIVDTSGRH--MQEESLFEEMEQVSQAVNPDEVIFVMDSSIGQSV 209
                 4566666666444443..25899**********************9866655 PP

>> Herpes_V23  Herpesvirus VP23 like capsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.7    0.0011       1.3     197     260 ..     313     382 ..     291     450 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0011
  Herpes_V23 197 lktlvlsl......lillaLiPrllarylnaLlrhdgsrllnvfeelvpkdldalsvk.ddltrlsslltm 260
                 +++ ++s+      ++++ +iP    ++l +   ++++ +l+++ ++ ++ +++++++  d+t+l  + + 
  EFC38552.1 313 MREHFTSImkmgplSQVMSMIPGFSEQLLPKGSEQESNARLKKYLTI-MDSMNDTEMDcTDITKLPNMQSR 382
                 555555555667779*******************************9.88888877764688888766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (454 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       799  (0.0445647); expected 358.6 (0.02)
Passed bias filter:                      619  (0.0345251); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.72u 0.38s 00:00:01.10 Elapsed: 00:00:00.55
# Mc/sec: 2501.89
//
Query:       EFC38553.1  [L=985]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      1e-27   97.6  27.6      1e-27   97.6  27.6    2.1  2  eIF3_subunit     Translation initiation factor eIF3 subunit
    2.1e-17   62.8   0.0      6e-17   61.4   0.0    1.7  1  MaoC_dehydratas  MaoC like domain
    2.8e-07   30.6   1.8    9.7e-07   28.9   0.1    2.7  3  PPR_2            PPR repeat family
    1.3e-06   28.3   0.8    0.00033   20.7   0.2    3.3  2  PPR_3            Pentatricopeptide repeat domain
    0.00021   20.7   0.6    0.00068   19.1   0.6    1.9  1  PPR_long         Pentacotripeptide-repeat region of PRORP
    0.00053   20.1   0.0     0.0027   17.9   0.0    2.2  2  MaoC_dehydrat_N  N-terminal half of MaoC dehydratase
  ------ inclusion threshold ------
      0.021   15.0   0.7         28    5.3   0.2    3.9  3  PPR              PPR repeat
       0.65   10.0   2.6        2.3    8.3   0.1    3.1  3  DUF768           Protein of unknown function (DUF768)
        4.3    7.3   7.4       0.17   11.8   0.4    2.3  2  Nas2_N           Nas2 N_terminal domain


Domain annotation for each model (and alignments):
>> eIF3_subunit  Translation initiation factor eIF3 subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.7   2.9         9   1.8e+04     205     206 ..      78      79 ..      40     119 .. 0.49
   2 !   97.6  27.6   5.1e-31     1e-27      19     242 .]     746     985 .]     734     985 .] 0.82

  Alignments for each domain:
  == domain 1  score: -5.7 bits;  conditional E-value: 9
  eIF3_subunit 205 eK 206
                   e 
    EFC38553.1  78 EH 79 
                   11 PP

  == domain 2  score: 97.6 bits;  conditional E-value: 5.1e-31
  eIF3_subunit  19 avaa.kWddEd.ededvk........dswdaeeeeeeekekakkaaeakak.aakakkkkskkqkiaekeerrkaeeeeaeeeeeleeedeaarker 104
                     a+ +W+d + +d++          d+w++ + + +ek+++++ ++++++ a++ +++k kkq+ +e++  +k++e++++++ ++ + d++ + + 
    EFC38553.1 746 LLANlSWEDAEiDDKPFSstqttagdDDWEDFDLDAVEKKQQEELKKKQEQlAEAERQEKLKKQQQKEQK-SNKKAETRTTSSGNAPTGDKKVEGMY 841
                   3333699996635556658888899999999999999888887777777778999999999999999998.78888889999*************** PP

  eIF3_subunit 105 lrkaeeesDlknaadlFGgvattketdlssldlfnpktkedFeelrkalaekltklekksphYssfleelirdlakslssedikkvassltvlaneK 201
                   l  +e++  ++ a+ l+Gg+   +e +  ++dl+ pkt+++F+e+  ++a+kl ++e++ + Y ++++ ++ + +++++s++++++++++t+++n +
    EFC38553.1 842 LDYMEKKTSYDEAEALIGGA--GSEFAKPKIDLLSPKTEKEFNEFGVLVADKLLEFEDS-KFYLDLVKRIVEEATINWDSAQLRELTKHVTNVSNKR 935
                   ******************87..4899*******************************55.5************************************ PP

  eIF3_subunit 202 qkeeKaaekggKkkkkakakts.lkadteaydddd.........ddyDDFM 242
                   + eeK++++ggKkkkk+ + +  l+a  + + +d           d DDFM
    EFC38553.1 936 MEEEKERKAGGKKKKKTVNIERdLSASADPF-SDLgdgtggrtkYDDDDFM 985
                   *******999999998777666322222222.2224445666555558**9 PP

>> MaoC_dehydratas  MaoC like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.4   0.0     3e-20     6e-17      16     110 ..     631     725 ..     620     737 .. 0.85

  Alignments for each domain:
  == domain 1  score: 61.4 bits;  conditional E-value: 3e-20
                      EEEEHHHHHHHHHHHT---GGGT-HHHHHHTT.TSSSB--HHHHHHHHHHHHHHHHSTTEGGGEEEEEEEE-S--BTTCEEEEEEEEEEEEEEE CS
  MaoC_dehydratas  16 itvteadialyalvsgDlnpiHvdpefAkkag.fggpIahGmltlaivaklveeelgdnvvarvgeikvrFtkpVlpgdtlkvelevvgkrdvr 108
                      ++ + +d+  +a +sgD+np+H+d++fAk  g f+ +I+hG l++++++ l  + l+    + + +++++F kpV+++++++v+++ ++  + +
       EFC38553.1 631 RSFNSQDVSDFAKLSGDYNPLHFDADFAKIHGmFKDRIVHGVLVSSLISNLAGTVLPG-AGSIYMSQELKFLKPVYIDQEITVSVQIKEALSTK 723
                      5566899**********************754399***************99999988.7788***********************99955544 PP

                      EE CS
  MaoC_dehydratas 109 kt 110
                      k+
       EFC38553.1 724 KS 725
                      44 PP

>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   0.1   4.9e-10   9.7e-07       2      48 ..     129     176 ..     128     178 .. 0.92
   2 !   10.3   0.1   0.00032      0.63       2      29 ..     165     192 ..     164     193 .. 0.97
   3 ?   -1.1   0.0       1.1   2.3e+03       9      31 ..     213     235 ..     207     238 .. 0.86

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 4.9e-10
       PPR_2   2 dvvtyNtlIsglck.kgkveeAfklfneMkkrglePnsyTysilikgl 48 
                 d+ +y ++I+ + + ++++ +Af+++n+Mkk g + n+ T++ l++ +
  EFC38553.1 129 DIRVYSAIIKSMENdANHIGDAFQVYNDMKKGGKKGNVATFTHLLNVC 176
                 6778********987999***************************976 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00032
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneM 29 
                 +v t+++l++ + +++++  A+ +++eM
  EFC38553.1 165 NVATFTHLLNVCITANHLTRALYVMKEM 192
                 89************************** PP

  == domain 3  score: -1.1 bits;  conditional E-value: 1.1
       PPR_2   9 lIsglckkgkveeAfklfneMkk 31 
                 lI  ++ ++++  A+ +++ M++
  EFC38553.1 213 LIRLCYINNEPGRAVAVYDCMRN 235
                 88889999***********9986 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.2   1.7e-07   0.00033       2      41 ..     153     192 ..     128     193 .. 0.96
   2 ?    4.3   0.0     0.021        43       1      22 [.     590     611 ..     590     616 .. 0.93

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 1.7e-07
       PPR_3   2 ilremerkgikldvvtYthLLtayanagnkklalevlerm 41 
                 + ++m++ g k +v t+thLL++++ a  + +al+v+++m
  EFC38553.1 153 VYNDMKKGGKKGNVATFTHLLNVCITANHLTRALYVMKEM 192
                 6789***********************************9 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.021
       PPR_3   1 silremerkgikldvvtYthLL 22 
                 si++e ++k ik + ++Y+hL 
  EFC38553.1 590 SIKDEEVKKQIKEEFYDYIHLV 611
                 699*****************96 PP

>> PPR_long  Pentacotripeptide-repeat region of PRORP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.6   3.4e-07   0.00068      17     119 ..     104     195 ..      88     249 .. 0.60

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 3.4e-07
                 HHHHHHHHT-HHHHHHHHHHHHHSSS---HHHHHHHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHH CS
    PPR_long  17 qldkCskekDaaaAlelydkavaegvrlaqyhynvllylcskaeaaseskknkalargfevfeamkakgvspnEatvtalarlaaakedgdlafelvke 115
                 ++   +k++  +aA+e+y +   +g  l    y++++  +        +++ + + ++f+v+++mk+ g + n at+t l  ++  ++   +a  ++ke
  EFC38553.1 104 EIYAAAKQHNPKAAIEAYHRCS-HG--LDIRVYSAIIKSM--------ENDANHIGDAFQVYNDMKKGGKKGNVATFTHLLNVCITANHLTRALYVMKE 191
                 5555555555555555554432.22..2233444444322........222234778888888888888888888888888888888888888888888 PP

                 HHHH CS
    PPR_long 116 meka 119
                 m  +
  EFC38553.1 192 MMLY 195
                 8643 PP

>> MaoC_dehydrat_N  N-terminal half of MaoC dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       5.7   1.1e+04      17      44 ..      74     112 ..      68     124 .. 0.59
   2 !   17.9   0.0   1.3e-06    0.0027      14     117 ..     633     733 ..     624     747 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 5.7
  MaoC_dehydrat_N  17 eavrefakavge...........tnpayldeeaaraagy 44 
                      ++++e+   v++            n  y+de +a+a  +
       EFC38553.1  74 KEIQEHNAKVNApgtkkeqvvstRNKQYIDEIYAAAKQH 112
                      555555555544444444444436677888888766665 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 1.3e-06
  MaoC_dehydrat_N  14 vereavrefakavgetnpayldeeaaraagyrsliaPptflivlatkapellealgidlsrllhgeqefeyhepiraGDelttesriadvyd.k 106
                       + ++v +fak  g++np+++d + a+  g+ +  +   +l+   ++    l    +++++ +  +qe+++ +p++ + e+t++ +i++    k
       EFC38553.1 633 FNSQDVSDFAKLSGDYNPLHFDADFAKIHGMFKDRIVHGVLVSSLISN---LAGTVLPGAGSIYMSQELKFLKPVYIDQEITVSVQIKEALStK 723
                      67899*********************9886544444444444333444...466779999***************************9765449 PP

  MaoC_dehydrat_N 107 kgvGalefivv 117
                      k+ G  ++i  
       EFC38553.1 724 KS-GNKKVIFI 733
                      87.66665543 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0      0.15   2.9e+02      16      30 ..     147     161 ..     144     161 .. 0.83
   2 ?    5.3   0.2     0.014        28       2      27 ..     168     193 ..     167     195 .. 0.95
   3 ?    3.1   0.0     0.068   1.4e+02       6      28 ..     213     235 ..     209     237 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.15
         PPR  16 leeAlelfkeMkekG 30 
                 + +A++++++Mk+ G
  EFC38553.1 147 IGDAFQVYNDMKKGG 161
                 568*********966 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.014
         PPR   2 tynslIsgycknGkleeAlelfkeMk 27 
                 t++ l++++  ++ l  Al ++keM 
  EFC38553.1 168 TFTHLLNVCITANHLTRALYVMKEMM 193
                 9************************6 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.068
         PPR   6 lIsgycknGkleeAlelfkeMke 28 
                 lI+ +  n+++  A+ +++ M+ 
  EFC38553.1 213 LIRLCYINNEPGRAVAVYDCMRN 235
                 899******************86 PP

>> DUF768  Protein of unknown function (DUF768)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       3.9   7.8e+03      47      55 ..     327     335 ..     315     339 .. 0.74
   2 ?   -0.7   0.0      0.72   1.4e+03      40      58 ..     423     441 ..     404     446 .. 0.79
   3 ?    8.3   0.1    0.0012       2.3      22      54 ..     566     597 ..     561     605 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.9
      DUF768  47 eeieeeves 55 
                 +e++eev++
  EFC38553.1 327 TEVDEEVSR 335
                 79****987 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.72
      DUF768  40 kaagikseeieeevesvye 58 
                 k  g++++ei+ ev+s  +
  EFC38553.1 423 KNNGLSEKEIKLEVDSFKA 441
                 7899**********99765 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0012
      DUF768  22 ksDvvsiaeLteklfadAkaagikseeieeeve 54 
                  +D++si+e t + +  Ak a i s + +eev 
  EFC38553.1 566 SEDIISIDEVTTETIERAKQAYIDSIK-DEEVK 597
                 79******************9998844.55555 PP

>> Nas2_N  Nas2 N_terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.4   8.4e-05      0.17       6      72 ..     311     378 ..     310     382 .. 0.93
   2 ?   -5.0   1.6         9   1.8e+04       5      24 ..     780     799 ..     778     808 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8.4e-05
      Nas2_N   6 kkkdeiekeieelsevLe.sqnvgmdgplvDeegFPrsDidvvavrtaRnriiclqNDlkelmkeiee 72 
                 ++++  e+e+++l    e +++v  +++ +D + +  s  d+++ r++  +  +l ND  ++ +++ +
  EFC38553.1 311 EQRATFEAELRKLKRLTEvDEEVSRENKALDFDEYGLSTRDHLELRSITLNTPMLANDQSDVDQSLRQ 378
                 68999********97777********************************************999877 PP

  == domain 2  score: -5.0 bits;  conditional E-value: 9
      Nas2_N   5 ekkkdeiekeieelsevLes 24 
                 ++  ++ ++e+++ +e+L +
  EFC38553.1 780 DAVEKKQQEELKKKQEQLAE 799
                 55556667777777777764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (985 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2864  (0.159741); expected 358.6 (0.02)
Passed bias filter:                      792  (0.0441742); expected 358.6 (0.02)
Passed Vit filter:                       111  (0.00619109); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 1.05u 0.35s 00:00:01.40 Elapsed: 00:00:00.53
# Mc/sec: 5643.58
//
Query:       EFC38554.1  [L=1033]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-26   91.6   1.5    7.7e-22   77.5   0.1    2.5  2  SNF2_N    SNF2 family N-terminal domain
    2.7e-19   69.4   0.0      8e-19   67.9   0.0    1.8  1  DUF1086   Domain of Unknown Function (DUF1086)
    5.3e-06   26.2   1.5    0.00023   21.0   0.0    3.0  2  Chromo    Chromo (CHRromatin Organisation MOdifier) domain
    1.3e-05   25.5   1.1     0.0001   22.6   0.1    2.9  2  CHDCT2    CHDCT2 (NUC038) domain
    0.00093   19.2   0.0    0.00093   19.2   0.0    3.8  4  ResIII    Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> SNF2_N  SNF2 family N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.5   0.1   2.1e-25   7.7e-22      29     208 ..     195     356 ..      83     362 .. 0.87
   2 !   13.1   0.3     8e-06     0.029     249     349 ..     367     462 ..     358     463 .. 0.82

  Alignments for each domain:
  == domain 1  score: 77.5 bits;  conditional E-value: 2.1e-25
                 ....................HHHHHTT--EEE---TTS--HHHHHHHHH...HHTTTS---.......S-EEEE--HHHHHHHHHHHHHH-TTS-EEE- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N  29 tldgekiyvnpatgevveesaeakqsvrGGiLaDemGLGKTvqvlalilaqrakeekdkekkrkdtlagptLivvPaslldqWeneierhvsssalrvl 127
                 tl   +  +  ++ + ve  ++  +++ +++L+De+GLGKTvq+++++             + k+ l+gp+Liv P + l  W +++e ++++  +  +
  EFC38554.1 195 TLTNPHTELMSYQKQAVEWLISSWKKHDNCVLSDEPGLGKTVQTISFLS------------IMKRYLSGPFLIVTPPQRLPFWNSQLEVWAPELVTATF 281
                 5566666677777778888889999************************............678899******************************** PP

                 -SSHHHH-----------------EEEE-HHHHHHHT......TTS-S-S-SEEEES-GGGT--TTSHHHHHHHH---S-E CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 128 vyggqkkmkkkntkvapklladydvvittYdvlsreaelqkkrsvlkqvewkrvvlDEghtlknstskaaeavskLstsnr 208
                 ++++q k++ k++ +++k     +v++tt+d +  +       s +k  +w  +vlD +h+++ns++k    +++L+ +  
  EFC38554.1 282 IGSNQDKQMIKRHLIQDKNNFYSNVILTTFDSMILDE------SWFKLHNWPIIVLDQAHKIRNSKTKSFSLMKRLQYNFL 356
                 ***9999999999999999999************888......999************************99999986655 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 8e-06
                 HHHHHHHHHHHHHTT-STTEE---GGGT--S---EEEEEEEEE--HHHHHHHH....................HHHHHH-HHH-HHHHHHHHHHHHH-- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 249 ieaqaekgrsrLlqllqrlmlrrakkdveknlPpkteeiiflklskverksYnrllevlrkkalakllkrseaalkssskskekilelllelrqacnhp 347
                  ++ ++k +  L+ +  + +lrr k++++  + pk+  ii ++ls+ ++++  ++  +      +++ +++  + ++++     ++   ++l +acnhp
  EFC38554.1 367 TTHDEYKEILDLARISPNSILRREKNNLKDVFKPKSDLIIEIPLSPLQKNYLAKIFRQNSSVLCQVFDEKNYSKENKDR-----LIRAYQQLSNACNHP 460
                 55666777777888888899********999******************999977777777777777777766666666.....99************9 PP

                 -X CS
                 xx RF
      SNF2_N 348 ql 349
                 +l
  EFC38554.1 461 YL 462
                 86 PP

>> DUF1086  Domain of Unknown Function (DUF1086)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.9   0.0   2.2e-22     8e-19      29     133 ..     811     924 ..     790     928 .. 0.89

  Alignments for each domain:
  == domain 1  score: 67.9 bits;  conditional E-value: 2.2e-22
     DUF1086  29 kslevLGFnerqRkaflnalmRyGv.....gdfdskelv....relkqktedeikaYgslFlrHlaeegadnsetfaDGvPkeGlsrqdvlvriavlsL 118
                  ++ v GF +++R +f +++ RyG+     +d +++++      +l+ k+ +eik++g+  l Hl e+ ++n + ++DG P + ++  ++l ri+ + L
  EFC38554.1 811 TNVLVKGFTRKERLVFYQTILRYGLgigstQDGKWQQFYsiinPKLRGKSIQEIKEFGAFILDHLSEQVDQNYSHYSDGTPTDSINGTKILQRIGSMFL 909
                 468899******************99999989999998633335899**************************************************** PP

     DUF1086 119 vkkkvkeleeipgkp 133
                 v+  v+++++ p ++
  EFC38554.1 910 VHSIVEKYSQFPIET 924
                 ******999988766 PP

>> Chromo  Chromo (CHRromatin Organisation MOdifier) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.3     0.033   1.2e+02      12      43 ..      64      92 ..      56     100 .. 0.80
   2 !   21.0   0.0   6.4e-08   0.00023      19      43 ..     131     155 ..     120     169 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.033
                ETTEECEEEEEEETTSTGGGTEEEEGGGCSSH CS
      Chromo 12 dkdgleleYlVKWkglpysentWEpeenlekc 43
                +++g    +lVK ++ +y +  W ++e+l ++
  EFC38554.1 64 REKG---NFLVKVRSKSYWDTVWMSREELNRK 92
                3444...5********************9987 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 6.4e-08
                 EEEEEETTSTGGGTEEEEGGGCSSH CS
      Chromo  19 eYlVKWkglpysentWEpeenlekc 43 
                 +YlVKW+glp se+t E+++ + + 
  EFC38554.1 131 QYLVKWRGLPISESTLETKSKIISN 155
                 8*****************9977655 PP

>> CHDCT2  CHDCT2 (NUC038) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.38   1.4e+03      37      83 ..      48      97 ..      14     127 .. 0.70
   2 !   22.6   0.1   2.8e-08    0.0001       5      66 ..     954    1016 ..     951    1031 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.38
      CHDCT2 37 inepFkseaekgn.fleiknkflar.rfklleqalvi.eeqlrraallnl 83
                ine F++++e  n  +  k  fl + r k   +++ + +e+l+r a+ +l
  EFC38554.1 48 INENFNDTNEVDNiIKREKGNFLVKvRSKSYWDTVWMsREELNRKATFKL 97
                78888888888664677788887653667666666653577888877765 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 2.8e-08
      CHDCT2    5 WhRrHDyWllagvvlhGyaRwqDiqndprfaiinepFkseaek..gnfleiknkflarrf.klle 66  
                  W+  HD  +l g  ++G+aRw  i +d+ f       k+ +++  +n +++k  fl++r+ klle
  EFC38554.1  954 WKLVHDLIVLRGCTKYGFARWDQILQDDTFEFTTL--KTIISSlfQNSKKMKIDFLNNRLiKLLE 1016
                  999*************************9976543..3333222245689*******99868887 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   2.6e-07   0.00093       3     160 ..     202     354 ..     200     360 .. 0.66
   2 ?    1.7   0.2     0.063   2.3e+02      46     118 ..     349     457 ..     342     480 .. 0.54
   3 ?   -2.1   0.1      0.91   3.2e+03      45      84 ..     492     535 ..     486     565 .. 0.59
   4 ?   -2.6   0.2       1.4   4.9e+03     102     118 ..     747     763 ..     716     804 .. 0.52

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 2.6e-07
                 EE-HHHHHHHHHHT......TTSEEEEEESTTSTHHHHH...HHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--.. CS
      ResIII   3 elreyQeeaienlleklkskrdkrglikmaTGtGKTlva...aklierllkkgkeekflflvprkslleqtleefkkflseaykeigkkvsgdkkka.. 96 
                 el +yQ++a+e l++++k  ++ + ++  + G GKT+     +++++r+l+      fl++ p + l   + ++++ +++e ++++    ++dk+++  
  EFC38554.1 202 ELMSYQKQAVEWLISSWK--KHDNCVLSDEPGLGKTVQTisfLSIMKRYLSG----PFLIVTPPQRLP-FWNSQLEVWAPELVTATFIGSNQDKQMIkr 293
                 7899*************6..999999**********8551256777777774....9******99885.344444444444443311112222222223 PP

                 ..........-SEEEEEHHHHHHTH........HHHTTT-SEEEEETGGGTTS.T..TTHHHHHT---S CS
      ResIII  97 ...kekdstnkkilvttiqsldadseeeeeeseellrdrfdviiiDEaHrlgakk..swreilekfkea 160
                    + k++  +++++tt +s+  d+         ++ ++ ++i+ D aH+++ +k  s+ ++++ ++ +
  EFC38554.1 294 hliQDKNNFYSNVILTTFDSMILDE-------SWFKLHNWPIIVLDQAHKIRNSKtkSF-SLMKRLQYN 354
                 3333344447889999999988888.......789999999*********999532222.234444554 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.063
                 HHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--................................................ CS
      ResIII  46 erllkkgkeekflflvprkslleqtleefkkflseaykeigkkvsgdkkka.........................................kekdstn 103
                 +rl+      +fl+lv +++ +  t +e+k++l+ a+ + + +++ +k++                                          k+++++n
  EFC38554.1 349 KRLQY-----NFLLLVSENIYTGTTHDEYKEILDLARISPNSILRREKNNLkdvfkpksdliieiplsplqknylakifrqnssvlcqvfdeKNYSKEN 442
                 33333.....89999998888888889996666666544333333333322222222233333333333333334444444444445555555555566 PP

                 -SEEEEEHHHHHHTH CS
      ResIII 104 kkilvttiqsldads 118
                 k+ l+  +q+l+++ 
  EFC38554.1 443 KDRLIRAYQQLSNAC 457
                 666666666666554 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.91
                 HHHH-S.....-EEEEESSHHHHHHHH....HHGGGGTGG.... CS
      ResIII  45 ierllkkgkeekflflvprkslleqtl....eefkkflseayke 84 
                  erll+k+++++++++     ++e +l    ++++ ++se++++
  EFC38554.1 492 LERLLEKFSQQNVIIFSSFPCIIEEMLiqqkKNYSIITSENVNN 535
                 45666666666666666666555555443335555555554444 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 1.4
                 ..-SEEEEEHHHHHHTH CS
      ResIII 102 tnkkilvttiqsldads 118
                 ++ + lv+ ++ +++++
  EFC38554.1 747 NTVESLVVDVENIKKAL 763
                 22333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1033 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1736  (0.0968264); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.90u 0.35s 00:00:01.25 Elapsed: 00:00:00.54
# Mc/sec: 5787.11
//
Query:       EFC38555.1  [L=202]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-35  120.8   0.0    4.8e-35  120.6   0.0    1.1  1  Ras       Ras family
    3.1e-13   50.0   0.0    6.4e-13   49.0   0.0    1.5  1  Roc       Ras of Complex, Roc, domain of DAPkinase
    0.00015   21.3   0.0    0.00039   19.9   0.0    1.6  1  Arf       ADP-ribosylation factor family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  120.6   0.0     8e-39   4.8e-35       1     160 [.       9     174 ..       9     176 .. 0.98

  Alignments for each domain:
  == domain 1  score: 120.6 bits;  conditional E-value: 8e-39
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 K+v+vGd+avGKt+l+  +v++kF+e y +T+ ++++    e++g +v+l iwDT      ++lr+l+y +a+ i+l+ +i   + f+n++ kw+ e++
  EFC38555.1   9 KCVVVGDGAVGKTCLVKVYVDNKFPEGYVPTV-FENTYLIKEYRGLRVNLGIWDT------DRLRPLSYPGANIIVLCLSIVGIKPFDNINyKWLPEVR 100
                 89******************************.**********************......89************************************ PP

                 HHSTTTSEEEEEEETTTGGG............G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee............kravsteegeelakelg.lkfletSAktnenveeafeellrei 160
                 ++++ n+p v+ ++K+Dl+e             + v+te+++e+++e++ + + e+S + n++v+e+fe +++++
  EFC38555.1 101 HHCP-NIPYVIAATKSDLREdpqslkelsnkgLQPVTTEQVKEFSDEIKaFGYQECSSRLNKGVNELFELVMKAV 174
                 ****.7************************9999***************99*******************99987 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.0   0.0   1.1e-16   6.4e-13       1     119 [.       9     116 ..       9     117 .. 0.85

  Alignments for each domain:
  == domain 1  score: 49.0 bits;  conditional E-value: 1.1e-16
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K v+vGd++vGKt+l+k +v++kf e + +t+  +++    ++ +g        +v+l iWDt      + l+pl + +a++++l++     + ++n++
  EFC38555.1   9 KCVVVGDGAVGKTCLVKVYVDNKFPEGYVPTVFENTYLI--KEYRG-------LRVNLGIWDT------DRLRPLSYPGANIIVLCLSivgIKPFDNIN 92 
                 789****************************97766542..23334.......3699*****9......68899999*******998866677888886 PP

                 .HHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  97 .eWlkelkkvagkspvilvgnkiD 119
                  +Wl e++++++++p ++ ++k D
  EFC38555.1  93 yKWLPEVRHHCPNIPYVIAATKSD 116
                 26********************99 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   6.6e-08   0.00039      11     172 ..       4     171 ..       1     174 [. 0.77

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 6.6e-08
                 .TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEEEE.E..TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHH CS
         Arf  11 kkkelrilllGLDnaGKtTilkklkleelvt.tvPTigfnveele.i..knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLk 105
                 ++ e++++++G  + GKt ++k + ++++ +  vPT+  n+  ++ +    +++ +wD    ++lRpl    ++  + ++ ++  +  + +++ + +  
  EFC38555.1   4 NETEIKCVVVGDGAVGKTCLVKVYVDNKFPEgYVPTVFENTYLIKeYrgLRVNLGIWD---TDRLRPL---SYPGANIIVLCLSIVGIKPFDNINYKWL 96 
                 6789*******9999*************98879****999877752422457788999...5899*98...589999******9999999999876543 PP

                 HHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSS.........SSSSEEEEEEBTTTTBTHHHHHHHHH CS
         Arf 106 alleeeelkevallvlaNKqDlpealseeelrellgleelk.........gkrkleiqkcsavkgeglkeglewls 172
                   + +++  +++ ++ a K Dl+e+ ++ +  ++ gl+ ++           + +  q+cs   ++g++e +e ++
  EFC38555.1  97 PEV-RHHCPNIPYVIAATKSDLREDPQSLKELSNKGLQPVTteqvkefsdEIKAFGYQECSSRLNKGVNELFELVM 171
                 333.4467799***********999877776677777776644444655555566777888888888888887766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (202 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.35s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1145.42
//
Query:       EFC38556.1  [L=503]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
        0.2   11.9   1.5         25    5.2   0.1    3.1  2  DUF5388         Family of unknown function (DUF5388)


Domain annotation for each model (and alignments):
>> DUF5388  Family of unknown function (DUF5388)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1    0.0021        37      38      59 ..     298     319 ..     279     322 .. 0.90
   2 ?    5.2   0.1    0.0014        25      34      57 ..     451     474 ..     424     478 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0021
     DUF5388  38 vkklveslidsLsesdkkrfkk 59 
                 ++k +e+l+ +Ls++d+k+f++
  EFC38556.1 298 IQKKQEYLLSKLSPDDRKQFEN 319
                 677789**************86 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0014
     DUF5388  34 qkeavkklveslidsLsesdkkrf 57 
                 q++ + kl+e++ d L+e+dk+rf
  EFC38556.1 451 QSTQLAKLLEKYPDVLNEEDKQRF 474
                 889999*****************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2403  (0.134029); expected 358.6 (0.02)
Passed bias filter:                      632  (0.0352502); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.54
# Mc/sec: 2821.60
//
Query:       EFC38557.1  [L=620]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (620 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1134  (0.0632495); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.53
# Mc/sec: 3505.16
//
Query:       EFC38558.1  [L=481]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.7e-33  115.9   3.4    3.8e-33  115.3   3.4    1.2  1  Bac_surface_Ag  Surface antigen


Domain annotation for each model (and alignments):
>> Bac_surface_Ag  Surface antigen
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.3   3.4   2.1e-37   3.8e-33       1     309 [.     126     458 ..     126     476 .. 0.81

  Alignments for each domain:
  == domain 1  score: 115.3 bits;  conditional E-value: 2.1e-37
                     STSSSS-EEEEEEEESSSEEEEEEEEEESTSSTTS-EEEEEEEEEE...GGGTBS.S-EEEEEEEEEEEEEEESSSEEEEEEEEEEEEEEES--- CS
  Bac_surface_Ag   1 NllGtGqslslsaslgsyeqslnlsftePyflgdrvslglslfare...sdsdesdsyrtksvgfsvslgrpltenyslslglsvqknkilkdss 92 
                     NllG++++  ++a++     + +l+++ + fl +  +  + l+ +       +       ++   +vs+ ++++ ++s+s+++++++n+   d +
      EFC38558.1 126 NLLGQADRWDVDANID----KTGLTLVGRTFLPQSFNNDGALYVSGflnG--GRVLTNLLQEKSNGVSVRAEINDRHSISYDFEMRRNE---DVG 211
                     8888888888888886....444555555555554444444444433222..222233345555567777889999****999999998...333 PP

                     BHHHHHHHH................................SCS--EEEEEEEEEEEEEEEEEESSSSS-SSEEEEEEEEEEE-..TTSSS-EEE CS
  Bac_surface_Ag  93 sennrnvss................................asklqtgksltsslslslsydtrddalfPtrGvllklrleftgpllggdvsylk 155
                     s  + + ss                                ++ + + +s +ssls+++ +dtr++++ P++G ++kl   ++g  lggdv+++ 
      EFC38558.1 212 SMFKKASSSgsfsrffsrfynaktqdsepvldkddsvvksqVWTEVKEQSVKSSLSHTYRFDTRNSSFAPSSGAFFKLVHRLAG--LGGDVKHYS 304
                     333333334567899999************999999876544******************************************..********* PP

                     EEEEEEEEEESSTTSSSEEEEEEEEEEEEESS..SS-.--GGG-B-BSSTTSSTEE.-TT-BS-EEEEEEE--BSEEEEEEEEEEEE-SSS-.GG CS
  Bac_surface_Ag 156 ldakasyyvpltkekdlvlaarvalgyisgyg..tkdelpfyerFyaGGsnsvRGf.esgglgprdesgdalGGdsyavaslElrfplpflk.kq 246
                     +d++++ +vpl  +++lv+a+++++g i ++   ++  + +++rF     + vRGf + g++ pr+  ++  GG+++ava+  l fp+p  +  q
      EFC38558.1 305 VDMNGEVFVPLI-SDSLVAALKLNVGTIIPLDrqNDTFISLNDRFI----EKVRGFpAVGTVHPRS--EEVYGGNIKAVATGRLVFPFPVSFiHQ 392
                     ************.78************9988766666689999996....8*****779******7..5********************999855 PP

                     TT.EEEEEEEEEEEEE-TT--TTTTTTS--TT..TS-EEEEEEEEEEEETTEEEEEEEEEEEE-ST CS
  Bac_surface_Ag 247 ns.vrlalFfDaGnvwdkegqspsssrsasst..aeirasvGvgLrwqsPlGPlrfdyAiplkked 309
                        +  ++F D+Gnv + +  s ++ ++++++  +++ +s+G gL +++ +G+++f++A+p +  +
      EFC38558.1 393 LLgLHCQAFCDIGNVSNINDYSENGVQQFREKfcKGLHTSYGFGLAMMLSFGRIEFNFAKPSTLFN 458
                     5449999********************99999****************************974443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.34s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 2731.61
//
Query:       EFC38559.1  [L=154]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       890  (0.0496402); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 954.05
//
Query:       EFC38560.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-21   77.1  16.9    1.4e-21   77.1  16.9    2.0  2  TRAM_LAG1_CLN8  TLC domain


Domain annotation for each model (and alignments):
>> TRAM_LAG1_CLN8  TLC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   1.3     0.027   4.8e+02     100     124 ..      39      63 ..      26      66 .. 0.70
   2 !   77.1  16.9   8.1e-26   1.4e-21       1     164 [.      65     222 ..      65     227 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.027
  TRAM_LAG1_CLN8 100 lvvlllhelsdpflnlrkilsylkk 124
                     +++++ + ls++++++ k+l++ kk
      EFC38560.1  39 VLFFVFYALSSVIFSTFKTLDFSKK 63 
                     4566677789999999999998865 PP

  == domain 2  score: 77.1 bits;  conditional E-value: 8.1e-26
  TRAM_LAG1_CLN8   1 kfdervvslvqyllstvfglivlssspelwegyperilgathfllkayyllalgYfiydllvlllyekkrkdfvemliHhiitlvllvlsyvrnl 95 
                     ++  r+vs +++++s++ +l+ + + p ++ +++ +  + ++   ++ + + +gYf ydll++l ++kk +  ++m++Hh++++++  l++ ++ 
      EFC38560.1  65 DWVSRLVSNFHAIVSFCGALYAILTYP-CYLTWN-FSCY-DNGIGELTMRYTIGYFCYDLLLILAFYKKLG-SIGMVLHHVFGILGWGLILSYGS 155
                     5889**********************9.555565.3333.45666669***********888888888877.5********************** PP

  TRAM_LAG1_CLN8  96 grvglvvlllhelsdpflnlrkilsylkkkskssklvlfngllfllsFfvcRlvllpylillsildvak 164
                     + ++++++ l e+++pf+n r++l+ + k+ k + l++  g+l+ l + ++R+ l+p++ ++ +l+++ 
      EFC38560.1 156 FSFVALMFTLTEATTPFVNQRWFLYEC-KM-KETSLYAAFGFLLWLAWSIVRVPLVPLCGYYLYLNYEG 222
                     ***************************.77.454444444******************99999988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       701  (0.0390987); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.23s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 1749.30
//
Query:       EFC38561.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.5e-52  176.1   0.0    9.8e-52  175.9   0.0    1.0  1  Pkinase         Protein kinase domain
    8.1e-33  113.8   0.0      1e-32  113.5   0.0    1.0  1  Pkinase_Tyr     Protein tyrosine kinase
    4.3e-08   32.3   0.0    5.8e-08   31.9   0.0    1.1  1  Pkinase_fungal  Fungal protein kinase
    3.8e-05   23.2   0.0    5.9e-05   22.5   0.0    1.2  1  Kinase-like     Kinase-like
  ------ inclusion threshold ------
      0.013   14.6   0.0      0.017   14.2   0.0    1.1  1  Seadorna_VP7    Seadornavirus VP7
      0.016   14.1   0.2      0.021   13.8   0.2    1.1  1  Haspin_kinase   Haspin like kinase domain
      0.028   13.8   0.1      0.067   12.5   0.1    1.6  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
      0.052   13.5   0.0       0.21   11.5   0.0    1.8  2  CTP_transf_3    Cytidylyltransferase
       0.11   12.0   0.1       0.19   11.2   0.1    1.3  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  175.9   0.0   4.9e-55   9.8e-52      65     264 .]       2     191 ..       1     191 [. 0.94

  Alignments for each domain:
  == domain 1  score: 175.9 bits;  conditional E-value: 4.9e-55
                 EEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGG CS
     Pkinase  65 evfeekdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtse 162
                 ++++++++l++ +e++++g+l+dl+  k++l e+e+  +++++l++l+ylH+++ +HrD+K++NiL+++kge+K++DFG++ el+++++  +s vgt+ 
  EFC38561.1   2 GAYQHNSHLWISMELMDCGKLTDLIY-KTILREDEIAYVLRETLKALKYLHDNNKMHRDIKSDNILVNSKGEIKLADFGFCVELSTKKEkHKSTVGTPF 99 
                 68999********************5.899******************************************************99988799******* PP

                 GS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTS CS
     Pkinase 163 YlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqh 261
                 ++APEv+++ ey+++vD+WslG++ +e+  g+pp+           el  l +++ i ++   +l+e+++ s ++ d+l+++l kdp++R + +ell+h
  EFC38561.1 100 WMAPEVIRAIEYGPNVDIWSLGIMALEMAEGEPPLI----------ELPVLRALFIIATQGPPTLKEPHKWSANFSDFLSRCLVKDPMERASSSELLEH 188
                 ************************************..........33444456667777789999********************************* PP

                 GGG CS
     Pkinase 262 pyl 264
                 p+l
  EFC38561.1 189 PFL 191
                 *97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.5   0.0   5.2e-36     1e-32      67     257 ..       1     187 [.       1     188 [. 0.92

  Alignments for each domain:
  == domain 1  score: 113.5 bits;  conditional E-value: 5.2e-36
                  EEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTS CS
  Pkinase_Tyr  67 lgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkee 164
                  +g++ ++++l+i +e+++ G+L + + k+    l+ +++  +  +  k+++yL++++ +Hrd+ + N+L++++  +k++DfG + ++  + + +k+++
   EFC38561.1   1 MGAYQHNSHLWISMELMDCGKLTDLIYKT---ILREDEIAYVLRETLKALKYLHDNNKMHRDIKSDNILVNSKGEIKLADFGFCVEL--STKKEKHKS 93 
                  58899999******************998...99*****************************************************..555566777 PP

                  STSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHH.HTT.EES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 165 aklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypglkneevlekl.keg.krlekpekcpeelyelmkkcweedpeeRptfselve 257
                  +     WmapE++++ ++  + D+Ws G++  E+++ ge p+ +l   ++l  + ++g   l++p+k+++++ +++++c+ +dp eR++ sel+e
   EFC38561.1  94 TVGTPFWMAPEVIRAIEYGPNVDIWSLGIMALEMAE-GEPPLIELPVLRALFIIaTQGpPTLKEPHKWSANFSDFLSRCLVKDPMERASSSELLE 187
                  888889****************************99.********99988888843331469***************************999876 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.9   0.0   2.9e-11   5.8e-08     308     396 ..      36     116 ..      26     120 .. 0.86

  Alignments for each domain:
  == domain 1  score: 31.9 bits;  conditional E-value: 2.9e-11
  Pkinase_fungal 308 llealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhD 396
                     +  +lr+ +k+++ L+ + + +HrDi  +Nil++     ++ +  L+D+ + +els+  ++++++  +GT+ +ma ev++++e  +  D
      EFC38561.1  36 IAYVLRETLKALKYLH-DNNKMHRDIKSDNILVN-----SKGEIKLADFGFCVELST--KKEKHKSTVGTPFWMAPEVIRAIEYGPNVD 116
                     55699***********.*****************.....677889***********5..5666689*************9887665555 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0     3e-08   5.9e-05     122     244 ..      17     128 ..       6     138 .. 0.79

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 3e-08
  Kinase-like 122 vdleilnkvlqkrsethkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggft...aLvragtkvvlsevekgf.aPpEllgs 215
                  +d + l ++++k   ++ + +++ r  l         +L+++  +h ++++dn+l + kg ++l +f+   +L ++++k + s+v   f   pE++ +
   EFC38561.1  17 MDCGKLTDLIYKTILREDEIAYVLRETLK-----ALKYLHDNNKMHRDIKSDNILVNSKGEIKLADFGfcvELSTKKEKHK-STVGTPFwMAPEVIRA 108
                  56688888888888888888888888884.....489******************************83334666666666.7777554256777655 PP

  Kinase-like 216 rggytrknktkmthkldaWqlGlviyriw 244
                            ++  ++d W lG+ ++ ++
   EFC38561.1 109 ---------IEYGPNVDIWSLGIMALEMA 128
                  .........667779*********99997 PP

>> Seadorna_VP7  Seadornavirus VP7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   8.5e-06     0.017     150     189 ..      43      80 ..      29      92 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 8.5e-06
  Seadorna_VP7 150 glkdLmdfhsestnllhGDcnpenlmcDknGylklvDPvs 189
                    lk+L+ +h  ++n +h D++ +n++ ++ G +kl D + 
    EFC38561.1  43 TLKALKYLH--DNNKMHRDIKSDNILVNSKGEIKLADFGF 80 
                   699******..8899*********************9765 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.2     1e-05     0.021     230     254 ..      57      81 ..       4      94 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1e-05
  Haspin_kinase 230 HRdLhldniLvdknlnvtlidlkls 254
                    HRd++ dniLv++++++ l d+  +
     EFC38561.1  57 HRDIKSDNILVNSKGEIKLADFGFC 81 
                    *********************9766 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   3.3e-05     0.067     128     173 ..      44      85 ..      13      94 .. 0.81
   2 ?   -1.7   0.0      0.77   1.5e+03     167     207 .]     169     207 ..     163     207 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.3e-05
         Kdo 128 grliaklhragvnHadlyaknillqqeeeeeaeiwliDldkarlrl 173
                  ++ + lh+ + +H+d+   nil++ ++    ei l D+  + + +
  EFC38561.1  44 LKALKYLHDNNKMHRDIKSDNILVNSKG----EIKLADFGFCVELS 85 
                 567789*********************9....99999998887665 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.77
         Kdo 167 dkarlrlradrwrekdLarLkrsflkielteadweallraY 207
                  ++  + + +r+++ +L  L+  flki+   + +++l++ Y
  EFC38561.1 169 SRCLVKDPMERASSSEL--LEHPFLKIACEPQKMADLMKKY 207
                 67888888888888887..7777789999999999999988 PP

>> CTP_transf_3  Cytidylyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.56   1.1e+03      64     105 ..      30      69 ..      15      75 .. 0.74
   2 ?   11.5   0.0   0.00011      0.21      17      61 ..     163     209 ..     162     212 .] 0.93

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.56
                   EE--TTCSSHHHHHHHHHHHHTTT.TTSEEEEE-TT-TT--H CS
  CTP_transf_3  64 lvtrsslesdterflevvkaflmseneeiivnlqGdnPllqe 105
                   ++++ ++  +++ +l+++k ++ +  +++  ++ +dn l+++
    EFC38561.1  30 ILREDEIAYVLRETLKALKYLHDN--NKMHRDIKSDNILVNS 69 
                   667777888888888888766555..7777777777777665 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.00011
                   GGSEETTEEHHHHHHHHHHHTTTTSE..EEEEES-HHHHHHHHHTTS CS
  CTP_transf_3  17 nlldlggkpliayvleaalkskafek..vivaTDseeiknvakefga 61 
                   n  d+++++l++ ++e+a +s+++e+  + +a+  +++++++k+++ 
    EFC38561.1 163 NFSDFLSRCLVKDPMERASSSELLEHpfLKIACEPQKMADLMKKYHL 209
                   6679**********************9999**************986 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   9.4e-05      0.19     112     157 ..      28      72 ..      15      80 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 9.4e-05
  YrbL-PhoP_reg 112 edlvkkeeltaelkeaLdefleelldnhivtndlsakNivvkknse 157
                    +++++++e++  l+e L+++ ++l dn+ + +d+++ Ni+v+ + e
     EFC38561.1  28 KTILREDEIAYVLRETLKAL-KYLHDNNKMHRDIKSDNILVNSKGE 72 
                    45669************997.69******************98776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       525  (0.0292822); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1390.45
//
Query:       EFC38562.1  [L=921]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-40  136.6   4.1      2e-09   37.2   0.1    6.7  6  Kelch_5       Kelch motif
    1.2e-38  130.9   3.6    1.8e-06   27.9   0.0    7.0  6  Kelch_4       Galactose oxidase, central domain
    3.5e-28   96.9   2.0    0.00011   21.8   0.0    6.5  6  Kelch_1       Kelch motif
    1.2e-27   95.6   8.6    3.2e-09   36.9   0.1    7.4  8  Kelch_3       Galactose oxidase, central domain
    2.5e-25   87.8   5.0    0.00023   21.3   0.0    6.4  6  Kelch_6       Kelch motif
    5.8e-17   60.9   8.5    0.00065   19.6   0.2    6.6  6  Kelch_2       Kelch motif
    1.5e-16   60.6   0.0    2.9e-16   59.6   0.0    1.5  1  SAM_1         SAM domain (Sterile alpha motif)
    1.2e-12   47.7   0.0    2.5e-12   46.7   0.0    1.5  1  SAM_2         SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
       0.12   11.4   0.0         14    4.6   0.0    2.4  2  DUF2048       Abhydrolase domain containing 18
       0.18   12.5   0.9        3.4    8.5   0.0    2.5  2  Occludin_ELL  Occludin homology domain


Domain annotation for each model (and alignments):
>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.1   5.1e-06    0.0092       2      38 ..      41      83 ..      40      87 .. 0.78
   2 !   13.3   0.0   3.4e-05     0.061       1      34 [.      99     133 ..      99     138 .. 0.83
   3 !   28.8   0.0   4.9e-10   8.9e-07       1      39 [.     261     299 ..     261     301 .. 0.89
   4 !   37.2   0.1   1.1e-12     2e-09       2      42 .]     314     352 ..     314     352 .. 0.98
   5 !   23.3   0.0   2.6e-08   4.6e-05       1      42 []     365     405 ..     365     405 .. 0.92
   6 !   13.1   0.0     4e-05     0.071       3      39 ..     416     451 ..     414     453 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5.1e-06
     Kelch_5  2 PppRaghcavtv...sek......iYvyGGkvgrdgsvsddvyvLd 38
                P++R+ghc+v +   +        + ++GG++g  ++  +d++ +d
  EFC38562.1 41 PSARWGHCSVLLhhhN-InsfhptLMIFGGFDG--SNMLNDIHLFD 83
                99********764442.0344566********6..99999999876 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 3.4e-05
     Kelch_5   1 iPppRaghcavtv...sekiYvyGGkvgrdgsvsddv 34 
                 iP++R+gh++  +   ++ki+++GG +g   ++  d+
  EFC38562.1  99 IPSARSGHSTTLLtkeKGKILLIGGGNG--VHYLADL 133
                 7**********776557**********6..8777776 PP

  == domain 3  score: 28.8 bits;  conditional E-value: 4.9e-10
     Kelch_5   1 iPppRaghcavtvs..ekiYvyGGkvgrdgsvsddvyvLdl 39 
                 +P+pR++h av+ +  +k++v+GG +   + ++ddv+v+ +
  EFC38562.1 261 YPAPRSRHTAVATEdgSKVIVFGGGG--KNRIFDDVWVFHV 299
                 6**********76335**********..9*********865 PP

  == domain 4  score: 37.2 bits;  conditional E-value: 1.1e-12
     Kelch_5   2 PppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdlpsf 42 
                 P+pR+gh+a+++s+k++vyGG+    +s  +d+y Ldl++f
  EFC38562.1 314 PCPRWGHSACIHSGKMFVYGGVF--KSSMLNDLYSLDLNTF 352
                 9**********************..9*************99 PP

  == domain 5  score: 23.3 bits;  conditional E-value: 2.6e-08
     Kelch_5   1 iPppRaghcavtv..sekiYvyGGkvgrdgsvsddvyvLdlpsf 42 
                 iP+pRa h a  v   + ++++GG +   +++ dd+y++dl+++
  EFC38562.1 365 IPSPRAAHTANLVlgRYLLILWGGDD---MKYLDDIYIFDLKTN 405
                 7*********98775599999*****...************997 PP

  == domain 6  score: 13.1 bits;  conditional E-value: 4e-05
     Kelch_5   3 ppRaghcavtv.sekiYvyGGkvgrdgsvsddvyvLdl 39 
                  +R  h ++ v +++++v+GG ++  ++ + ++y +d+
  EFC38562.1 416 KARCAHTSCLVdDNYLFVFGGGGS--HQRFKELYLFDI 451
                 5677788987626**********6..888888887776 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.1   1.7e-08     3e-05       2      43 ..      44      91 ..      43     101 .. 0.74
   2 !    9.2   0.0   0.00065       1.2       1      36 [.     102     138 ..     102     152 .. 0.81
   3 !   27.9   0.0   9.9e-10   1.8e-06       1      43 [.     264     306 ..     264     315 .. 0.88
   4 !   22.0   0.0   6.7e-08   0.00012       1      45 [.     316     362 ..     316     367 .. 0.88
   5 !   16.1   0.0   4.8e-06    0.0085       1      44 [.     368     410 ..     368     416 .. 0.83
   6 !   26.0   0.1   3.7e-09   6.6e-06       1      37 [.     417     452 ..     417     453 .. 0.96

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1.7e-08
     Kelch_4  2 Raghsatsi....pdg....tiylfGGrgedgtllndlylldlstntWrr 43
                R+gh+++ +      +    t+ +fGG  +    lnd++l+d  tntW++
  EFC38562.1 44 RWGHCSVLLhhhnI-NsfhpTLMIFGGFDGS-NMLNDIHLFDSVTNTWSQ 91
                66666666654320.1344599********9.7***************75 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00065
     Kelch_4   1 pRaghsatsi..pdgtiylfGGrgedgtllndlylldl 36 
                 +R ghs+t +   +g+i l+GG ++    l+dl ll +
  EFC38562.1 102 ARSGHSTTLLtkEKGKILLIGGGNGV-HYLADLVLLEV 138
                 7*********8777********8887.78888888866 PP

  == domain 3  score: 27.9 bits;  conditional E-value: 9.9e-10
     Kelch_4   1 pRaghsatsipdg.tiylfGGrgedgtllndlylldlstntWrr 43 
                 pR  h+a+++ dg ++++fGG g +  +++d++++ ++  +W++
  EFC38562.1 264 PRSRHTAVATEDGsKVIVFGGGGKN-RIFDDVWVFHVQEMEWSQ 306
                 8*********7755**********9.9***************76 PP

  == domain 4  score: 22.0 bits;  conditional E-value: 6.7e-08
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtllndlylldlstntWrrl....g 45 
                 pR+ghsa+   +g+ +++GG     + lndly ldl t  W+++    +
  EFC38562.1 316 PRWGHSACIH-SGKMFVYGGVFKS-SMLNDLYSLDLNTFVWTKIelptS 362
                 9*********.7***********9.8************99999977442 PP

  == domain 5  score: 16.1 bits;  conditional E-value: 4.8e-06
     Kelch_4   1 pRaghsatsi.pdgtiylfGGrgedgtllndlylldlstntWrrl 44 
                 pRa h+a  + ++  ++l+GG  +d++ l+d+y++dl+tn+ +r+
  EFC38562.1 368 PRAAHTANLVlGRYLLILWGG--DDMKYLDDIYIFDLKTNSGKRI 410
                 899999999977779999998..5668*************86666 PP

  == domain 6  score: 26.0 bits;  conditional E-value: 3.7e-09
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtllndlylldls 37 
                 +R+ h+++ ++d+++++fGG g+  +++++lyl+d++
  EFC38562.1 417 ARCAHTSCLVDDNYLFVFGGGGSH-QRFKELYLFDIK 452
                 7999*******************9.9*********97 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.0   5.9e-08   0.00011       8      41 ..      58      91 ..      52      94 .. 0.86
   2 ?    4.0   0.0      0.02        36      12      27 ..     116     131 ..     115     147 .. 0.85
   3 !   16.6   0.0   2.4e-06    0.0042       2      41 ..     267     306 ..     265     309 .. 0.90
   4 !   19.0   0.1   4.3e-07   0.00077       4      42 ..     319     357 ..     316     358 .. 0.95
   5 !    8.8   0.0   0.00067       1.2       5      37 ..     373     405 ..     369     406 .. 0.75
   6 !   19.8   0.0   2.5e-07   0.00045       1      35 [.     418     452 ..     418     454 .. 0.94

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 5.9e-08
                EEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEE CS
     Kelch_1  8 vvvggkiYviGGsdggnalssvevyDpetntWre 41
                 ++   + ++GG+dg+n l+++  +D++tntW++
  EFC38562.1 58 NSFHPTLMIFGGFDGSNMLNDIHLFDSVTNTWSQ 91
                566677899***********************97 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.02
                 TEEEEEEEBCSSSBEE CS
     Kelch_1  12 gkiYviGGsdggnals 27 
                 gki  iGG++g  +l 
  EFC38562.1 116 GKILLIGGGNGVHYLA 131
                 9*********966655 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 2.4e-06
                 BBSEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEE CS
     Kelch_1   2 ragagavvvggkiYviGGsdggnalssvevyDpetntWre 41 
                 r+ a+a+  g k+ v+GG+  ++  ++v+v+ + + +W++
  EFC38562.1 267 RHTAVATEDGSKVIVFGGGGKNRIFDDVWVFHVQEMEWSQ 306
                 6777888899***********************9999986 PP

  == domain 4  score: 19.0 bits;  conditional E-value: 4.3e-07
                 SEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEEE CS
     Kelch_1   4 gagavvvggkiYviGGsdggnalssvevyDpetntWrel 42 
                 g++a+ + gk++v GG + ++ l++++ +D+ t  W+++
  EFC38562.1 319 GHSACIHSGKMFVYGGVFKSSMLNDLYSLDLNTFVWTKI 357
                 89**********************************985 PP

  == domain 5  score: 8.8 bits;  conditional E-value: 0.00067
                 EEEEEETTEEEEEEEBCSSSBEEEEEEEETTTT CS
     Kelch_1   5 agavvvggkiYviGGsdggnalssvevyDpetn 37 
                  +  v+g ++ ++ G+d+ ++l++++++D++tn
  EFC38562.1 373 TANLVLGRYLLILWGGDDMKYLDDIYIFDLKTN 405
                 5556666666666677777*************9 PP

  == domain 6  score: 19.8 bits;  conditional E-value: 2.5e-07
                 BBBSEEEEEETTEEEEEEEBCSSSBEEEEEEEETT CS
     Kelch_1   1 aragagavvvggkiYviGGsdggnalssvevyDpe 35 
                 ++a+ ++ v +++++v+GG+ ++++ + ++ +D +
  EFC38562.1 418 RCAHTSCLVDDNYLFVFGGGGSHQRFKELYLFDIK 452
                 699****************************9976 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.2       1.6   2.9e+03      31      47 ..      30      50 ..      19      52 .. 0.73
   2 !   36.9   0.1   1.8e-12   3.2e-09       4      48 ..      64     110 ..      62     111 .. 0.94
   3 ?    0.4   0.0      0.49   8.8e+02       2      32 ..     116     147 ..     115     155 .. 0.81
   4 ?   -1.3   0.0       1.7     3e+03      26      48 ..     250     272 ..     249     272 .. 0.81
   5 !   18.9   0.0   7.3e-07    0.0013       1      48 [.     276     324 ..     276     325 .. 0.86
   6 !   21.3   0.0   1.4e-07   0.00024       2      47 ..     327     375 ..     326     377 .. 0.91
   7 ?    0.8   0.0      0.36   6.4e+02      15      48 ..     391     425 ..     380     426 .. 0.77
   8 !   13.8   0.0     3e-05     0.054       1      27 [.     428     452 ..     428     457 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.6
     Kelch_3 31 Wa....eiaslppaRaghaat 47
                Wa    +++ +p+aR gh+++
  EFC38562.1 30 WAipspSLGISPSARWGHCSV 50
                66433334788*******976 PP

  == domain 2  score: 36.9 bits;  conditional E-value: 1.8e-12
     Kelch_3   4 lyifGGlgddgqdrlndvyvydldtntWaei....aslppaRaghaata 48 
                 l ifGG++  g + lnd +++d +tntW +     ++ p+aR+gh++t+
  EFC38562.1  64 LMIFGGFD--GSNMLNDIHLFDSVTNTWSQPsktfGTIPSARSGHSTTL 110
                 669*****..*******************99999************995 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.49
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtn...tWa 32 
                 ++++++GG +  g  +l d+ ++ ++++   +W+
  EFC38562.1 116 GKILLIGGGN--GVHYLADLVLLEVVSEedeEWK 147
                 579999**99..9999999999988777667776 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 1.7
     Kelch_3  26 ldtntWaeiaslppaRaghaata 48 
                 ld+ ++++    p +R+ h+a+a
  EFC38562.1 250 LDSLNFTMKEIYPAPRSRHTAVA 272
                 677778888889********985 PP

  == domain 5  score: 18.9 bits;  conditional E-value: 7.3e-07
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaei...aslppaRaghaata 48 
                 g ++ +fGG g   +    dv+v+ ++  +W +     + p +R gh+a+ 
  EFC38562.1 276 GSKVIVFGGGG--KNRIFDDVWVFHVQEMEWSQPqdsTNKPCPRWGHSACI 324
                 56899******..9******************9974444566*******95 PP

  == domain 6  score: 21.3 bits;  conditional E-value: 1.4e-07
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWaei.....aslppaRaghaat 47 
                 ++++++GG        lnd+y++dl+t  W++i     ++ p++Ra h+a 
  EFC38562.1 327 GKMFVYGGVF--KSSMLNDLYSLDLNTFVWTKIelptsDPIPSPRAAHTAN 375
                 579*******..99*****************8888887889********86 PP

  == domain 7  score: 0.8 bits;  conditional E-value: 0.36
     Kelch_3  15 qdrlndvyvydldtntWaei.aslppaRaghaata 48 
                  ++l d y +dl tn+ ++i   +p aR+ h++++
  EFC38562.1 391 MKYLDDIYIFDLKTNSGKRIsFKSPKARCAHTSCL 425
                 67788999999999998888444666999999985 PP

  == domain 8  score: 13.8 bits;  conditional E-value: 3e-05
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydld 27 
                 +++l++fGG g  + +r +++y++d+ 
  EFC38562.1 428 DNYLFVFGGGG--SHQRFKELYLFDIK 452
                 69*********..************86 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   2.2e-05     0.039      13      42 ..      63      91 ..      52     100 .. 0.88
   2 ?    1.0   0.0      0.34     6e+02       2      22 ..     103     126 ..     102     148 .. 0.75
   3 !   18.0   0.0   1.4e-06    0.0025       1      42 [.     264     306 ..     264     312 .. 0.89
   4 !   20.2   0.1   2.8e-07   0.00051       1      50 []     316     369 ..     316     369 .. 0.89
   5 !    9.4   0.0   0.00073       1.3       1      39 [.     368     406 ..     368     411 .. 0.77
   6 !   21.3   0.0   1.3e-07   0.00023       1      36 [.     417     452 ..     417     454 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.2e-05
     Kelch_6 13 kiYifGGytdsspylnkvwvydpetksWeq 42
                +++ifGG ++ s+ ln+++++d  t++W+q
  EFC38562.1 63 TLMIFGGFDG-SNMLNDIHLFDSVTNTWSQ 91
                79********.8999*************97 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.34
     Kelch_6   2 raghslvsvg...gkiYifGGytd 22 
                 r ghs+++     gki ++GG ++
  EFC38562.1 103 RSGHSTTLLTkekGKILLIGGGNG 126
                 677888775545589******998 PP

  == domain 3  score: 18.0 bits;  conditional E-value: 1.4e-06
     Kelch_6   1 praghslvs..vggkiYifGGytdsspylnkvwvydpetksWeq 42 
                 pr  h++v+   g+k+ +fGG +  +  +++vwv++++ + W+q
  EFC38562.1 264 PRSRHTAVAteDGSKVIVFGGGGK-NRIFDDVWVFHVQEMEWSQ 306
                 57889997756677********99.9****************97 PP

  == domain 4  score: 20.2 bits;  conditional E-value: 2.8e-07
     Kelch_6   1 praghslvsvggkiYifGGytdsspylnkvwvydpetksWeqlp.....plpvpr 50 
                 pr+ghs++++ gk +++GG    s+ ln+++ +d+ t +W++++     p+p pr
  EFC38562.1 316 PRWGHSACIHSGKMFVYGGVFK-SSMLNDLYSLDLNTFVWTKIElptsdPIPSPR 369
                 79******************99.8899***************9766766677776 PP

  == domain 5  score: 9.4 bits;  conditional E-value: 0.00073
     Kelch_6   1 praghsl..vsvggkiYifGGytdsspylnkvwvydpetks 39 
                 pra+h++  v+    + ++GG +   +yl++++++d++t+s
  EFC38562.1 368 PRAAHTAnlVLGRYLLILWGGDDM--KYLDDIYIFDLKTNS 406
                 577888852334445677799998..9************97 PP

  == domain 6  score: 21.3 bits;  conditional E-value: 1.3e-07
     Kelch_6   1 praghslvsvgg.kiYifGGytdsspylnkvwvydpe 36 
                 +r++h++++v++ ++++fGG +  +++++ ++++d++
  EFC38562.1 417 ARCAHTSCLVDDnYLFVFGGGGS-HQRFKELYLFDIK 452
                 69*****997755********99.***********96 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.1   0.00081       1.5      16      44 ..      66      91 ..      64      94 .. 0.92
   2 !    6.3   0.0    0.0058        10       1      33 [.     102     134 ..     102     152 .. 0.80
   3 !   17.9   0.0   1.2e-06    0.0021       1      44 [.     264     306 ..     264     310 .. 0.87
   4 !   19.6   0.2   3.7e-07   0.00065       1      45 [.     316     357 ..     316     360 .. 0.92
   5 ?    0.2   0.0      0.48   8.6e+02      24      41 ..     389     406 ..     376     406 .. 0.77
   6 !    6.3   0.0    0.0057        10       2      25 ..     418     439 ..     417     454 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00081
     Kelch_2 16 vvGGahtdnpnlsssdvhvldlekhvWee 44
                ++GG+   +++   +d+h +d  +++W+ 
  EFC38562.1 66 IFGGF---DGSNMLNDIHLFDSVTNTWSQ 91
                89***...*******************85 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0058
     Kelch_2   1 rrgghsssvp...ggkiyvvGGahtdnpnlsssdvh 33 
                 +r+ghs++ +    gki+++GG    n++++  d+ 
  EFC38562.1 102 ARSGHSTTLLtkeKGKILLIGGG---NGVHYLADLV 134
                 5899999999999*********9...8887777765 PP

  == domain 3  score: 17.9 bits;  conditional E-value: 1.2e-06
     Kelch_2   1 rrgghsssvp..ggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44 
                 +r++h+++    g+k++v+GG    ++n+ ++dv+v+  ++ +W+ 
  EFC38562.1 264 PRSRHTAVATedGSKVIVFGGG---GKNRIFDDVWVFHVQEMEWSQ 306
                 5777777755589*********...*******************86 PP

  == domain 4  score: 19.6 bits;  conditional E-value: 3.7e-07
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 +r ghs++   gk++v+GG+    +++  +d++ ldl++ vW++ 
  EFC38562.1 316 PRWGHSACIHSGKMFVYGGV---FKSSMLNDLYSLDLNTFVWTKI 357
                 5779****************...*******************985 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.48
     Kelch_2  24 npnlsssdvhvldlekhv 41 
                 ++  + +d++++dl++++
  EFC38562.1 389 DDMKYLDDIYIFDLKTNS 406
                 4778899*******9985 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.0057
     Kelch_2   2 rgghsssvp.ggkiyvvGGahtdnp 25 
                 r+ h+s+ + ++ ++v+GG    ++
  EFC38562.1 418 RCAHTSCLVdDNYLFVFGGG---GS 439
                 7888888777*********6...44 PP

>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.6   0.0   1.6e-19   2.9e-16       4      62 ..     575     633 ..     572     635 .. 0.94

  Alignments for each domain:
  == domain 1  score: 59.6 bits;  conditional E-value: 1.6e-19
                 THSSHHHHHHHTTSGGGHHHHHTTTSSHHHHTTSCHHHHHHCTTTSHHHHHHHHHHHHH CS
       SAM_1   4 svedVgeWLesiglgqYadlFrageidgdaLlllteddLeklgvtllGHrkkIlyaIqr 62 
                 + ++V++WL  +glg+Ya+ F ++eid++++ llt+ dL klg++++G+rkkIl a ++
  EFC38562.1 575 DIKEVTNWLVNLGLGRYANMFVQEEIDLECIPLLTDTDLFKLGISKFGPRKKILDAAKK 633
                 5689**************************************************99876 PP

>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.7   0.0   1.4e-15   2.5e-12       3      64 ..     573     633 ..     571     634 .. 0.95

  Alignments for each domain:
  == domain 1  score: 46.7 bits;  conditional E-value: 1.4e-15
                 GHHHHHHHHHHHHTTTGGGHHHHHHTTCSHHHHHTTSCHHHHHHTTHHHHHHHHHHHHHHHH CS
       SAM_2   3 swsledvaeWLrsiglkqytdnFrdagitgaelllrlteedLkrlGitsvghrkkilkkiqe 64 
                 s++ ++v++WL ++gl++y+++F + +i+  e ++ lt  dL +lGi+++g+rkkil ++++
  EFC38562.1 573 SKDIKEVTNWLVNLGLGRYANMFVQEEIDL-ECIPLLTDTDLFKLGISKFGPRKKILDAAKK 633
                 78999*************************.**************************99885 PP

>> DUF2048  Abhydrolase domain containing 18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.012        22     257     322 ..     137     202 ..     128     205 .. 0.88
   2 ?    4.6   0.0    0.0079        14     125     140 ..     697     712 ..     683     725 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.012
     DUF2048 257 kldeakerkaekealrfmrllmdelthlknfsvpkdtsliivvaAkdDayvpresvaslqeiwpgs 322
                 ++ ++++++++ke+    + +  +++++ ++s pk  s + v   +dD  +++e+ ++lqe   +s
  EFC38562.1 137 EVVSEEDEEWKKESQLLGNNSGIKCMNMFRWSRPKVSSRVRVYISDDDIILTEEQFQKLQEEINNS 202
                 56677888999999999999****************************999******999876665 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0079
     DUF2048 125 siilenpfYglrkPke 140
                 ++il npfYg r+P+ 
  EFC38562.1 697 TLILSNPFYGFRHPTA 712
                 78************86 PP

>> Occludin_ELL  Occludin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.2      0.23   4.1e+02      34      57 ..     188     211 ..     182     236 .. 0.67
   2 ?    8.5   0.0    0.0019       3.4       9      48 ..     468     507 ..     465     527 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.23
  Occludin_ELL  34 vskkfseLerelkelkegskeykk 57 
                   ++++f++L++e++++k++ +e+++
    EFC38562.1 188 TEEQFQKLQEEINNSKNNPSEISE 211
                   57899******9999999884433 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0019
  Occludin_ELL   9 qrerYkaeFnkeYkeYkelhaeleevskkfseLerelkel 48 
                     ++++++F+++++ Y  l + l+++s+ f e+++++k  
    EFC38562.1 468 SDDEFEENFSTDFSDYLCLSQYLDKASQSFLEVRSDIKVE 507
                   567899**************************99887744 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (921 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       911  (0.0508115); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.80u 0.28s 00:00:01.08 Elapsed: 00:00:00.49
# Mc/sec: 5605.43
//
Query:       EFC38563.1  [L=484]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.7e-24   83.9   5.1    6.5e-05   23.5   0.1    7.1  6  RCC1      Regulator of chromosome condensation (RCC1) repeat
    1.9e-16   59.4  27.1    8.1e-05   22.3   1.6    7.5  8  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.027   2.4e+02       6      47 ..      15      72 ..      10      74 .. 0.54
   2 !   11.8   0.0   3.2e-05      0.29       3      44 ..      81     126 ..      80     132 .. 0.76
   3 !   15.9   0.1   1.7e-06     0.015       3      49 ..     225     276 ..     224     277 .. 0.84
   4 !   14.9   0.0   3.3e-06      0.03       5      50 .]     284     331 ..     281     331 .. 0.80
   5 !   23.5   0.1   7.3e-09   6.5e-05       4      49 ..     337     395 ..     335     396 .. 0.75
   6 !   10.5   0.1   8.3e-05      0.74       3      48 ..     401     445 ..     399     447 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.027
                EEE--GGGTTSSSS---E........EEE..........EE-GGGTTS-EEEEEEETTEE CS
        RCC1  6 sWGrndyGqLGlgttesv........lvP..........tkveglsgnrvvkvacGddht 47
                + G n+ GqL   + +++        + P          +k++ +    ++ ++cG+ h 
  EFC38563.1 15 TAGHNHAGQLVSEDFVDHyqlhkvklPFPdwletgnaltRKIKKPI--TIKRASCGAAHM 72
                5566666666665553333322222222344444444444454444..889999999995 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 3.2e-05
                 EEEEEE--GGGTTSSSS---EEEEEE-...GGGTTS.-EEEEEEET CS
        RCC1   3 rVysWGrndyGqLGlgttesvlvPtkv...eglsgn.rvvkvacGd 44 
                 ++y  G+n++ qLGl +++ v   tk+   ++l +n ++++v++G 
  EFC38563.1  81 DLYVVGKNSEFQLGLSNNKPVKELTKIdtnKFLLKNeKITDVFAGT 126
                 58*************9995553336776665555558******996 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 1.7e-06
                 EEEEEE--GGGTTSS...SS---EEEEEE-GGGTTS..-EEEEEEETTEEEE CS
        RCC1   3 rVysWGrndyGqLGl...gttesvlvPtkveglsgn..rvvkvacGddhtva 49 
                 ++++ G+n y+q G+   g++ ++l+  k++g +++  +v+ vacG++h+v 
  EFC38563.1 225 QIFGRGSNAYHQYGRnfdGQNFERLTEIKLKGYEKQppNVKLVACGGFHSVI 276
                 57889**********988777666666777888877*9************97 PP

  == domain 4  score: 14.9 bits;  conditional E-value: 3.3e-06
                 EEEE--GGGTTSSSS---E...EEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   5 ysWGrndyGqLGlgttesv...lvPtkveglsgnrvvkvacGddhtval 50 
                 y+ G n +GqLG   ++++     P  +++ +g++++ va G +htv++
  EFC38563.1 284 YCSGLNCHGQLGYDVEKTQydfIEPPNLPF-KGKEITNVALGLYHTVVV 331
                 7779*********88855544333878855.789************986 PP

  == domain 5  score: 23.5 bits;  conditional E-value: 7.3e-09
                 EEEEE--GGGTTSSSS---E......EE.....EEE-GGGTTS..-EEEEEEETTEEEE CS
        RCC1   4 VysWGrndyGqLGlgttesv......lv.....Ptkveglsgn..rvvkvacGddhtva 49 
                 +y +G + yGqLG+g ++s       l+     P+  ++ +     ++ v+cG  htv 
  EFC38563.1 337 IYVCGDGRYGQLGNGENKSInpvfsrLKleavsPVTGNFIRHMntFIIGVSCGLTHTVI 395
                 8****************6654334332244556777777765599************97 PP

  == domain 6  score: 10.5 bits;  conditional E-value: 8.3e-05
                 EEEEEE--GGGTTSSSS-..--EEEEEE-GGGTTS-EEEEEEETTEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt..esvlvPtkveglsgnrvvkvacGddhtv 48 
                 +V+ +G nd+Gq  l+++   ++     v++ ++ ++ +v+cG+ +t+
  EFC38563.1 401 KVWRCGGNDFGQIFLKNElqTCS---FSVTFEPRCEINQVSCGGKFTA 445
                 58999**********99995444...677888877***********98 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1     0.019   1.7e+02      15      30 .]       5      23 ..       4      23 .. 0.83
   2 !    6.2   0.0     0.001       9.3       1      28 [.      62      90 ..      62      92 .. 0.89
   3 ?    1.3   0.1     0.036   3.3e+02       6      30 .]     212     236 ..     210     236 .. 0.82
   4 ?   -1.4   0.2      0.25   2.3e+03      23      30 .]     237     244 ..     237     244 .. 0.92
   5 !   22.3   1.6     9e-09   8.1e-05       1      30 []     264     293 ..     264     293 .. 0.96
   6 !   17.7   0.2   2.4e-07    0.0022       2      30 .]     319     347 ..     318     347 .. 0.94
   7 !   22.0   0.9   1.1e-08    0.0001       1      30 []     383     412 ..     383     412 .. 0.95
   8 ?    0.4   0.0     0.066   5.9e+02       3      11 ..     436     444 ..     434     450 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.019
      RCC1_2 15 tedGe...VlcWGsNsdGQ 30
                t++G    +l+ G+N  GQ
  EFC38563.1  5 TSSGQnttLLTAGHNHAGQ 23
                566777779*********9 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.001
      RCC1_2  1 VksvsaGdyHscaLted.GeVlcWGsNsd 28
                +k  s+G+ H +  t+  ++++  G Ns 
  EFC38563.1 62 IKRASCGAAHMILRTNRlNDLYVVGKNSE 90
                56789***********99*********96 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.036
      RCC1_2   6 aGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +Gd+H +++   + +++ GsN + Q
  EFC38563.1 212 IGDDHCIVVNQYNQIFGRGSNAYHQ 236
                 79****9998888888888887766 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 0.25
      RCC1_2  23 WGsNsdGQ 30 
                 +G+N dGQ
  EFC38563.1 237 YGRNFDGQ 244
                 69*****9 PP

  == domain 5  score: 22.3 bits;  conditional E-value: 9e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 Vk v++G++Hs++++ ++e +c G N +GQ
  EFC38563.1 264 VKLVACGGFHSVIVLQNNEFYCSGLNCHGQ 293
                 6779*************************9 PP

  == domain 6  score: 17.7 bits;  conditional E-value: 2.4e-07
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 + v+ G yH+++++e  +++ +G+  +GQ
  EFC38563.1 319 TNVALGLYHTVVVVEHSTIYVCGDGRYGQ 347
                 56999***********************9 PP

  == domain 7  score: 22.0 bits;  conditional E-value: 1.1e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++ vs+G  H++++t+d +V+ +G N++GQ
  EFC38563.1 383 IIGVSCGLTHTVIVTSDRKVWRCGGNDFGQ 412
                 5679*************************9 PP

  == domain 8  score: 0.4 bits;  conditional E-value: 0.066
      RCC1_2   3 svsaGdyHs 11 
                 +vs+G+ ++
  EFC38563.1 436 QVSCGGKFT 444
                 8****9554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (484 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.28s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 3147.40
//
Query:       EFC38564.1  [L=538]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.2e-79  265.9   0.0    2.2e-78  264.3   0.0    1.7  1  Amidase   Amidase


Domain annotation for each model (and alignments):
>> Amidase  Amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  264.3   0.0   1.2e-82   2.2e-78       5     451 .]      75     514 ..      71     514 .. 0.90

  Alignments for each domain:
  == domain 1  score: 264.3 bits;  conditional E-value: 1.2e-82
                 HHHHHHHHHHHHH--EEEEEHCCCCHHHHT---TTT......TTTT-EEEEETTB--TTSB--TTSGGGTT-....B-SS--HHHHHHHHTT-EEEEEE CS
     Amidase   5 aflkrieavneklnalvtvfieealaqAakldkkrargkekgpLhGvPisvKDnidvkgvpttaGskaleny....paekDatvverLkkaGavilgkT 99 
                 + +k i++ n++l+a++  + +  l+qA++++k++++gke +++ GvP+++KD +d +g+ +t G+k+ e+     + ++++ v + L++ G++++gk+
  EFC38564.1  75 KAIKEIDEQNPSLKAVIKYDESLLLKQAEESTKRYEEGKEISVFDGVPVTIKDELDLAGFTSTKGMKVTEYTehviTEDEESNVSKSLRALGVMFVGKA 173
                 6788999************************************************************98864222245568****************** PP

                 --SGGG-SSSSTT-TT---BBTTCTCCB--SSSHHHHHHHHTTSSSCEEEEESSSTTHHHHHHCTSEEEE--TTSC--TTB-.-SSTTT-EEEEEESSH CS
     Amidase 100 nmdefamgsstensvfgptrNPwdksrtpGGSSGGsAAavAaglvplaiGtDtGGSiRiPAsfcglvGlKPtygrvSragvv.alessldvvGplarsv 197
                 n  e +  + + n  fg +rNP++++   GGSS+Gs+A v++gl pl+iGtD+GGS+RiP+s+cg++GlKPt+ r+S +    +++ s  v+Gp++ s+
  EFC38564.1 174 NQNEIGICARGINVNFGSARNPYNLQCDTGGSSSGSGAGVGSGLIPLSIGTDGGGSVRIPSSLCGVYGLKPTHYRISTKQKSaPVAFSTCVAGPMTGSA 272
                 *****************************************************************************999888**************** PP

                 HHHHHHHHHHBS--TT-TTS----.....HHHHHHHHCTT---TT-EEEEEGGGCSS---CCHHHHHHHHHHHH..HCTT-EEEEEE-CCGGGHHHHHH CS
     Amidase 198 edlalllrvilgedpkdstssvip.....eesedlaeelkkslkglriGvvkedgvasldpevqravekalkaL..eeaGhevvevelpsleealslyy 289
                  dl l + +++g+ ++d +s+  p     + +  l  + + +l++ +iG+ ++++ +  d+ + ++ +++++++  +  ++++ +  +  l e  +++ 
  EFC38564.1 273 IDLTLSFAAVAGRRSNDLKSLTQPrdlrlN-EIRLMDPDYYNLNERKIGIHNDYFNDVKDNRIPKLCRDFIEKVfcKIYNAQIDDSIVIPLLEPSRVSH 370
                 **********************99999854.567888888899*************9999999999999999862144456676655555555555555 PP

                 HHHHHHHHHHTTT-SSSSS---SS-SCCCCCCCHHHHCCS-HHHHHHHHHHHHHCSCCCCCCCHHHHHHHHHHHHHHHHHHCCCBSEEEEESSSSS--B CS
     Amidase 290 lilvaeassnlarylgvryerlsetkvlsellpksraellgeevkrrielgnyalsaeasskyylkaqkvrrllrrefakafeelDvllsPtaptpapr 388
                 l+  a  + n +    +         +   +++   +++l +e++ ++  ++ya s++     y++aq+vr+  ++efak+fe++Dv+++Pt+ + ap+
  EFC38564.1 371 LVTIAGEMRNGM----K---------D-YGYYEYDKRSKLCPETRMSLLSQKYASSSD-----YITAQRVRSHQMDEFAKLFEKVDVIALPTVGCVAPE 450
                 555544444433....3.........3.57899999999*****************99.....9*********************************** PP

                 CCCCCHHH.....CSHHHHHGCCTTT...HHHHHTT--EEEEECCCCT.TECEEEEEEESTT-HHHHH CS
     Amidase 389 lgekdkti.....dsytvlynlldftavvvpvnlaglpalsvpagksedglPvGvqvigkafqeetlL 451
                  +e + +       +y vl  +++f+   +  n+ g p++s+p+g+ + + PvG+q+++k ++e tlL
  EFC38564.1 451 FDESQVKKgglgvSDYDVLSSIMKFI---FTSNFCGFPSVSIPIGFID-NKPVGLQLMAKWWDEVTLL 514
                 ***99877899999************...*****************96.9****************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1017  (0.0567237); expected 358.6 (0.02)
Passed bias filter:                      695  (0.038764); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.34s 00:00:01.05 Elapsed: 00:00:00.51
# Mc/sec: 3162.66
//
Query:       EFC38565.1  [L=739]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      6e-60  202.8   0.8    2.5e-58  197.5   0.0    3.0  3  Pkinase      Protein kinase domain
    1.8e-33  115.9   0.2    9.8e-32  110.2   0.0    2.8  3  Pkinase_Tyr  Protein tyrosine kinase
    2.3e-06   27.2   0.0    6.3e-06   25.7   0.0    1.7  1  Kinase-like  Kinase-like
  ------ inclusion threshold ------
      0.075   13.0   0.0        2.4    8.0   0.0    2.2  2  APH          Phosphotransferase enzyme family
       0.13   11.6   0.0       0.24   10.7   0.0    1.4  1  Kdo          Lipopolysaccharide kinase (Kdo/WaaP) family
       0.27   11.5   0.9        2.3    8.5   0.0    2.8  3  XRN1_D2_D3   Exoribonuclease Xrn1 D2/D3 domain
        1.1    9.1   9.4      0.094   12.6   3.2    2.4  2  Sec34        Sec34-like family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.1     0.039     1e+02     208     259 ..      19      86 ..       1      89 [. 0.62
   2 ?   -1.3   0.2      0.44   1.1e+03      52      96 ..     288     337 ..     266     350 .. 0.66
   3 !  197.5   0.0   9.6e-62   2.5e-58       6     264 .]     388     693 ..     384     693 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.039
                 HHHHTHHHHHHHCT.SHH...HHHTTS.................-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 208 keldqlekilkilg.etkeklpeasei.................seeakdllkkllkkdpkkRltaeell 259
                 ++l+q  +++ +++  t+++  +as++                 s + +dl+k+ll+ +p+  +  ++l 
  EFC38565.1  19 QQLQQ--QLIPTFNmSTNNQPTHASSLtpslnnievvgndnipsSGTNIDLIKQLLNSNPQLQMYLHQLA 86 
                 33333..12222221233333333333667777788999999989999************9877766665 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.44
                 HHHHSCTTB--EEEEEEE...SSEEEEEEE--TTEBHHHHHH..HHSS-- CS
     Pkinase  52 lkklkhpnivrlyevfee...kdelylvleyveggeladlle..rkgsls 96 
                 l+  +h+ iv+l+++ ++   +++ ++++    +++++  ++   + sl+
  EFC38565.1 288 LQLHQHQPIVNLLYSTSTtinQNNHHMIQPQTTNTQFNMEISpsPSLSLQ 337
                 45566999999998888777778888888888888888777744334444 PP

  == domain 3  score: 197.5 bits;  conditional E-value: 9.6e-62
                 EEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE......SSEEEEEEE--TTEB...HHHHHHHHSS CS
     Pkinase   6 klGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee......kdelylvleyvegge...ladllerkgs 94 
                  lG+G++G V+ a ++++g +vA+Kk+++  +k   +  +lrE+ki+++l+ hpniv+l+++f         ++ly+v e+++g+    +++l ++k++
  EFC38565.1 388 FLGRGAYGHVIAANDTQSGTTVAIKKVQNVFDKAAYR--MLREVKIMRHLRgHPNIVTLIDIFIPgntlneFKDLYIVSECMNGDLgrvMTNLCNQKQC 484
                 69****************************9998775..************************998999999***********8866656666669999 PP

                 --HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS....BCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHH CS
     Pkinase  95 lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk....ltsfvgtseYlAPEvl.keneyskkvDvWslGvily 188
                 ls +++++i+ q+l+++ yl s+g++HrD+Kp+NiL+++k ++K++DFG++++  ++++     +  v+t+ Y++PEv+ +++  ++++D Ws+G+i++
  EFC38565.1 485 LSIDNIRDIMGQLLSAMYYLQSAGVLHRDMKPSNILLSHKFQVKLSDFGMSRNEATNQQvtnpQSFAVVTEIYRPPEVVlNYEIQTSAIDSWSVGCIFA 583
                 ****************************************************99998887885666799**********556666************** PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS...............................................-HHHHHH CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilgetkeklpeasei...............................................seeakdl 240
                 ell+  pp s+++       +l++          ++   p+++e                                                ++ea+dl
  EFC38565.1 584 ELLYMLPPSSKRRP---LFVILKD----------SEIRAPNHYEHlnlmasllgkpktnelkgnpqyvqellellenfpsqgydfslifpaaPPEAIDL 669
                 ****9999993322...2222222..........111111111112222333444444455566666799***************************** PP

                 HHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 241 lkkllkkdpkkRltaeellqhpyl 264
                 +k+ l+++p++R+++ee+l+hp++
  EFC38565.1 670 MKRFLTWNPESRISFEEALNHPFI 693
                 **********************97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1      0.66   1.7e+03      42      76 ..     146     180 ..     102     198 .. 0.72
   2 !  110.2   0.0   3.8e-35   9.8e-32       7     200 ..     389     587 ..     385     620 .. 0.84
   3 ?    2.2   0.0     0.035        90     229     255 ..     661     687 ..     632     690 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.66
                  HHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSE CS
  Pkinase_Tyr  42 eeekeelleeakimkklkhpnivkllgvctkeepl 76 
                  + ++++++++a+ m++ + ++i++l+    + ++l
   EFC38565.1 146 QLQEHNITSNAQPMMHGDSQHILSLYLSSEEVQQL 180
                  44456667777777777777777776555544443 PP

  == domain 2  score: 110.2 bits;  conditional E-value: 3.8e-35
                  EEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE......SSSSEEEEEE--TTEBHHHHHHHT.. CS
  Pkinase_Tyr   7 lGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvct......keepllivteyvkgGdLlkfLrkk.. 95 
                  lG+Ga+G+V+ ++ +    ++ ++Va+K++++  ++    ++l+e+kim++l  hpniv l+ + +      + + l+iv e ++ GdL   +++   
   EFC38565.1 389 LGRGAYGHVIAANDT----QSGTTVAIKKVQNVFDKA-AYRMLREVKIMRHLrGHPNIVTLIDIFIpgntlnEFKDLYIVSECMN-GDLGRVMTNLcn 480
                  9*********99988....999********8888777.899***********99**********995544433344999999775.555555554322 PP

                  CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEE.TTSSTSGGGGS-HHHHHHSE.EEHHHHHHHH CS
  Pkinase_Tyr  96 ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvk.keeaklpvkWmapEslkekk.ftsksDvWsf 191
                  +k+ l+++++ +++ q+ ++m yL+s  ++Hrd+   N+Lls++ +vk+sDfG++r+  ++++ ++ ++ a +   + +pE++ + +  ts+ D Ws 
   EFC38565.1 481 QKQCLSIDNIRDIMGQLLSAMYYLQSAGVLHRDMKPSNILLSHKFQVKLSDFGMSRNEATNQQVTNpQSFAVVTEIYRPPEVVLNYEiQTSAIDSWSV 578
                  49*******************************************************966666655044455666799***988777367788***** PP

                  HHHHHHHHT CS
  Pkinase_Tyr 192 GvllwEift 200
                  G +  E++ 
   EFC38565.1 579 GCIFAELLY 587
                  ******986 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.035
                  TSBHHHHHHHHHHT-SSGGGS--HHHH CS
  Pkinase_Tyr 229 kcpeelyelmkkcweedpeeRptfsel 255
                   +p+e  +lmk+ ++ +pe+R +f+e 
   EFC38565.1 661 AAPPEAIDLMKRFLTWNPESRISFEEA 687
                  4789999*****************986 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   0.0   2.5e-09   6.3e-06     152     238 ..     496     580 ..     460     607 .. 0.82

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 2.5e-09
  Kinase-like 152 qlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvl.seve.....kgfaPpEllgsrggytrknktkmthkldaWqlGl 238
                  ql+    +Lq+ g++h ++++ n+ll +k++++l +f+  +   t+ ++ +        + + PpE++ +   y+       t ++d W +G 
   EFC38565.1 496 QLLSAMYYLQSAGVLHRDMKPSNILLSHKFQVKLSDFGMSRNEATNQQVtNPQSfavvtEIYRPPEVVLN---YEI-----QTSAIDSWSVGC 580
                  66777789******************************999999988874544477777899*****988...555.....678899999996 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.022        57       3     103 ..     387     499 ..     385     504 .. 0.67
   2 ?    8.0   0.0   0.00094       2.4     162     187 ..     500     527 ..     481     537 .. 0.74

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.022
                 EEE--.SSCEEEEEEETT.-.-EEEEEE-TT..S-HHHHHHHHHHHHHHHHTT-B--B-C....TTBS-EEETTE..EEEEEE----EE-SS...HHHH CS
         APH   3 relsggasnrtylvttpa.g.ryvlrrnppa..raaeeirrevallrlLakagvpvPevl....agdtddeeigl..lfalieyvpgrsllr...klsa 88 
                  +l+ ga+ ++   ++++ g +++ + +     +aa ++ rev+++r+L++++  +  ++     g t +e++ l  +++ + +  gr++++   + ++
  EFC38565.1 387 VFLGRGAYGHVIAANDTQsGtTVAIKKVQNVfdKAAYRMLREVKIMRHLRGHPN-IVTLIdifiPGNTLNEFKDLyiVSECMNGDLGRVMTNlcnQKQC 484
                 578888888888888888764555666555556699999*************54.55555222334444444444557777777777777777776666 PP

                 HHHHHHHHHHHHHHC CS
         APH  89 aqlpellealgefla 103
                   ++++ + +g++l 
  EFC38565.1 485 LSIDNIRDIMGQLLS 499
                 666666666666665 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00094
                 S...SS-EEEE-SS-SGGGEEEC..TTEE CS
         APH 162 g...elptvllHgDlhpgNllvdpddgrv 187
                 +    +++++lH+D +p N+l+  ++ +v
  EFC38565.1 500 AmyyLQSAGVLHRDMKPSNILLS-HKFQV 527
                 35557899*************99.66665 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   9.2e-05      0.24      58     176 ..     425     542 ..     406     548 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 9.2e-05
         Kdo  58 avrEfrllkrLeea.gvavpkpvaagavkvgleyrAlllterlega..qdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqq 153
                 + rE+++++ L+    + ++  ++   +  + +    +++e ++g   + +++l+++ + l+    r ++ ++  ++  l +agv H+d+ + nill  
  EFC38565.1 425 MLREVKIMRHLRGHpNIVTLIDIFIPGNTLNEFKDLYIVSECMNGDlgRVMTNLCNQKQCLSIDNIRDIMGQLLSAMYYLQSAGVLHRDMKPSNILLSH 523
                 556666666665432455555555555555555666666666665211334445554333666666666666667777889*****************9 PP

         Kdo 154 eeeeeaeiwliDldkarlrlrad 176
                 +     ++ l D+  +r+ ++++
  EFC38565.1 524 KF----QVKLSDFGMSRNEATNQ 542
                 98....99999998888777654 PP

>> XRN1_D2_D3  Exoribonuclease Xrn1 D2/D3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       1.4   3.5e+03      24      49 ..     106     131 ..     101     135 .. 0.83
   2 ?    8.5   0.0   0.00091       2.3       8      40 ..     382     413 ..     380     433 .. 0.74
   3 ?   -1.1   0.0      0.86   2.2e+03      26      72 ..     509     555 ..     498     562 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.4
                 EEEEEESSSEEEEEEEBS-SS---SH CS
  XRN1_D2_D3  24 aevtghsekklsvvlaklksekepef 49 
                 a++++ ++++++ +l+ +++++e + 
  EFC38565.1 106 ATISDQTNSTIDNILSLFNQSNESNN 131
                 7899999999*999999999877765 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00091
                 TT-EEEE-SCTCTTEEEEEEEESSSEEEEEEEB CS
  XRN1_D2_D3   8 egskvffLGeyaYGrpaevtghsekklsvvlak 40 
                 +gs+v+fLG  aYG+ +  +++++++ +v ++k
  EFC38565.1 382 RGSQVVFLGRGAYGHVIAANDTQSGT-TVAIKK 413
                 599***********988887775443.344444 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.86
                 EEEESSSEEEEEEEBS-SS---SHHHHHHHHHHHHS-EE------EE CS
  XRN1_D2_D3  26 vtghsekklsvvlaklksekepefgkkrikeaeksnrYlpsfavakk 72 
                 v   + k  +++l+   + k  +fg +r +++++++    sfav  +
  EFC38565.1 509 VLHRDMKPSNILLSHKFQVKLSDFGMSRNEATNQQVTNPQSFAVVTE 555
                 55555666778888888889999999999999999999999999765 PP

>> Sec34  Sec34-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   3.2   3.7e-05     0.094      14      87 ..      66     139 ..      60     148 .. 0.93
   2 ?   -2.4   0.4       1.6   4.1e+03      11      64 ..     275     328 ..     239     330 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.7e-05
       Sec34  14 elleqtdealeqLeeleekfksvsektsslheaceqlleeqkrleelaeeieekLkyFeeldpitrkLnspgss 87 
                 +l++q+ + + qL+   ++  + +e+++s+ +++++ ++  +  ++++ +i++ L+ F++ ++ +++L++pg  
  EFC38565.1  66 DLIKQLLNSNPQLQMYLHQLANQTENSNSMLTTSNNNVKVATISDQTNSTIDNILSLFNQSNESNNMLQHPGNY 139
                 68999999999************************************************************987 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.6
       Sec34  11 ecdelleqtdealeqLeeleekfksvsektsslheaceqlleeqkrleelaeei 64 
                 ++ +++++ +    qL++ +  ++   + +++++++  ++++ q+  ++++ ei
  EFC38565.1 275 NTANIVRKHSIPDLQLHQHQPIVNLLYSTSTTINQNNHHMIQPQTTNTQFNMEI 328
                 344444444444455555555555566666666666666666666666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (739 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       955  (0.0532657); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 4578.79
//
Query:       EFC38566.1  [L=1668]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1668 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3020  (0.168442); expected 358.6 (0.02)
Passed bias filter:                      505  (0.0281667); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.47u 0.37s 00:00:01.84 Elapsed: 00:00:00.67
# Mc/sec: 7514.60
//
Query:       EFC38567.1  [L=4231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (4231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       877  (0.0489152); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.73u 0.35s 00:00:02.08 Elapsed: 00:00:00.61
# Mc/sec: 20971.29
//
Query:       EFC38568.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-93  313.5   3.7    3.8e-92  308.9   3.7    2.1  1  tRNA-synt_1d     tRNA synthetases class I (R)
    5.2e-06   26.6   1.3    0.00029   21.0   0.1    2.6  2  DALR_1           DALR anticodon binding domain
     0.0042   17.6   0.0      0.023   15.3   0.0    2.3  2  Arg_tRNA_synt_N  Arginyl tRNA synthetase N terminal domain
  ------ inclusion threshold ------
      0.056   12.8   0.0       0.13   11.6   0.0    1.7  1  tRNA-synt_1e     tRNA synthetases class I (C) catalytic domai
      0.093   12.3   0.0       0.16   11.6   0.0    1.3  1  Circo_capsid     Circovirus capsid protein
        0.1   12.9   0.2        4.5    7.7   0.1    2.6  2  DUF5601          Domain of unknown function (DUF5601)


Domain annotation for each model (and alignments):
>> tRNA-synt_1d  tRNA synthetases class I (R)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  308.9   3.7   1.3e-95   3.8e-92      15     349 .]      63     436 ..      52     436 .. 0.85

  Alignments for each domain:
  == domain 1  score: 308.9 bits;  conditional E-value: 1.3e-95
                   --SST-EEEEE----BTTS--BHHHHHHHHHHHHHHHHHHHCT.-EEEEEE--B-SSTCHHHHHHHHHHHTT..TTTTS---...--SCCCHHHHHH CS
  tRNA-synt_1d  15 ksrekkkvvvdfssPniakemhvGhLrstiiGdavsrlleflG.ydvirlnhvGDWGtqfGlLiaylekkqd..ekllqeqe...lqdLeafykeak 105
                   + ++k +v+vdfssPn+ak mhvGhLrstiiGd + r+le+ G ++v r+nhvGD+GtqfG+L+a++e++    ekl ++++   l+ +e++yk++k
    EFC38568.1  63 NVKDKIRVIVDFSSPNMAKRMHVGHLRSTIIGDCICRILEYDGrFEVERINHVGDFGTQFGMLLAFIERNSIdlEKLQTQNPpeqLETVEKYYKDSK 159
                   5788999***********************************989***********************986412555544442337777899***** PP

                   HHCCCSHCCCHHHHHHHHHHHCT-HH.HHHHHHHHHHHHHHHHHHHHHHCT---EC--CCCCCCCHHHHHHHHHCTT-EEECTTCEEEEECCC.... CS
  tRNA-synt_1d 106 kdydeeeifaerarnyvvkLqsgded.irklwkllvditrtelqklydrldvtlierGeslykeslneivkelkkkglvkesdGalvvfldef.... 197
                   k +d +  f++ a++ v+ Lq+g+++ i+k+wk l + +r e++ +y+rldv l+e+Ges y++ +++ +++l  + l++es+Ga+ +f ++     
    EFC38568.1 160 KLFDSDPLFKDLAHQKVIALQQGNDEsIHKIWKYLLECSRYEFDSIYERLDVRLVEKGESYYRDFIPKTLEIL--NPLIQESNGAKCIFTEKEqeti 254
                   ********************9886544*********************************************9..57************98776778 PP

                   ...TSSCCEECC-TTS-B-HHHHHHHHHHHHHHTT--SEEEEEEECCCHHHHHHHHHHHHCTTS.ST...........TT.......SEEEEEEE-- CS
  tRNA-synt_1d 198 ...gkrlgvvvqksDGgylytttDiaaakerkeelkadkvlyvidsrqslhlqqiflilkkigy.vp...........es.......kdlehanfGm 272
                       k+ +++vqk DGgy+y+ttD+a+  +r++  k   ++yv d +q  h++++f +  ++ + +p           ++       ++++h +fG+
    EFC38568.1 255 tedQKEPPLMVQKADGGYTYDTTDLATLWYRLFVSKGKWLIYVTDFGQASHFNKVFKVGEMMKWiDPlensrdlvwseNAtsltsskVRIDHVGFGV 351
                   877778899**************************************************99996244443333333331222222225689****** PP

                   EE-TTSSBSBCSSSTC-BHHHHHHHHHHHHHHHHCCCCCCTS-CCCCHC........HHHHHHHHHHHHCCCCTS-TTS-EE--H CS
  tRNA-synt_1d 273 vlgkdkkkfktrkGetvkLadlLdealeralqlikeknkdkvlqadele........kvaeavgvgaikyaDlsknrindyifdw 349
                   vl ++kkkf+tr+G+tvkL+dlLdea++r+ + ik kn ++  +++e          ++ + vg+ga+kyaDl+ nr+++y f++
    EFC38568.1 352 VLDEEKKKFRTRSGDTVKLHDLLDEAIKRSYEIIKLKNDERCKENEEISsltdeqimAASKIVGYGAVKYADLRTNRTTNYTFSF 436
                   **********************************9999888777776541111111145678*********************97 PP

>> DALR_1  DALR anticodon binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1     0.021        61      35      82 ..     164     212 ..     140     222 .. 0.78
   2 !   21.0   0.1   9.6e-08   0.00029       1      50 [.     450     509 ..     450     514 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.021
                 HHHHHHHHHTHHHHHHHHHHHT-THHHHHHHHHHHH.HHHHHHHHCTST CS
      DALR_1  35 ekeLlkalaqfpevleeaaeelephklaeylyeLaa.tfhkfYnkervl 82 
                    L+k la  + +  +  ++ ++hk+ +yl e +  +f + Y++  v 
  EFC38568.1 164 SDPLFKDLAHQKVIALQQGNDESIHKIWKYLLECSRyEFDSIYERLDVR 212
                 5568999999999999999**************9864899999977664 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 9.6e-08
                 HHHHHHHHHHHHHHTTCTTCCCCHCCHCC..........S-SHHHHHHHHHHHTHHHHHH CS
      DALR_1   1 vqyahaRiksilrkaeeegekleeealal..........leeeeekeLlkalaqfpevle 50 
                 ++ya+aRi+si +k++e +  +e++++             ++e+e++L+ ++ +f++v +
  EFC38568.1 450 LLYAYARISSIIEKSGERELMKEYKDQVAkgdlslftnlKQSESEWRLALKIIEFKDVYS 509
                 58***************9999999998889999*****66667*************9976 PP

>> Arg_tRNA_synt_N  Arginyl tRNA synthetase N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   7.6e-06     0.023      43      83 ..       1      42 [.       1      44 [. 0.88
   2 ?   -1.8   0.0       1.7     5e+03      30      46 ..     111     127 ..      92     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 7.6e-06
                     GG--TT-..-HHHHHHHHHHT---TTT.EEEEEEETT.EEEE CS
  Arg_tRNA_synt_N 43 mqlakklkknPreiAeeiaekleksei.iekvevagpGFiNf 83
                     mql ++lk++P ++A+ + e + ++ + +ek+++  +G i +
       EFC38568.1  1 MQLGNQLKQSPIDVAKSLGESILNNSEiVEKIDIINNGVISL 42
                     89999***************88877666*******9997765 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.7
                      SSGGG-SEEEEGGGG-- CS
  Arg_tRNA_synt_N  30 knpkfGDyatnvamqla 46 
                      + +  GD+ t   m la
       EFC38568.1 111 RINHVGDFGTQFGMLLA 127
                      56778999999888887 PP

>> tRNA-synt_1e  tRNA synthetases class I (C) catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   4.3e-05      0.13      18      59 ..      78     120 ..      63     242 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.3e-05
                   BTTS--BHHHHHHHHHHHHHHHHHHH.TT-EEEEEEEBB--SH CS
  tRNA-synt_1e  18 tvydashlGhaRslvafDilrrilqa.lgYdvqfvqnvtDidD 59 
                    +   +h+Gh Rs+++ D + ril++   ++v+ ++ v D   
    EFC38568.1  78 NMAKRMHVGHLRSTIIGDCICRILEYdGRFEVERINHVGDFGT 120
                   566789********************6669**99999999765 PP

>> Circo_capsid  Circovirus capsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   5.2e-05      0.16     147     213 ..     276     356 ..     233     367 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.2e-05
  Circo_capsid 147 kwdlsrgfkRlfrPkPql..titdldtanktaalwlnskrtlWi.Pl...........qgkpnssgdkVkhyGlafsfrqp 213
                   + dl   + Rlf+ k +    +td+++a++ ++ +  ++   Wi Pl            ++ +ss+ +++h+G+++ + + 
    EFC38568.1 276 TTDLATLWYRLFVSKGKWliYVTDFGQASHFNKVFKVGEMMKWIdPLensrdlvwsenATSLTSSKVRIDHVGFGVVLDEE 356
                   345667889***9988743499**********************888********987556679999********999887 PP

>> DUF5601  Domain of unknown function (DUF5601)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.073   2.2e+02       7      37 ..      53      85 ..      48     102 .. 0.79
   2 ?    7.7   0.1    0.0015       4.5      14      49 ..     141     176 ..     125     190 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.073
     DUF5601  7 vrki.sqrsisieelSemVqdFyq.nlaerlnk 37
                +++i  q+ +++ ++  ++ dF   n+a+r++ 
  EFC38568.1 53 ISEIfNQQPLNVKDKIRVIVDFSSpNMAKRMHV 85
                34441477**************86699999975 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0015
     DUF5601  14 sisieelSemVqdFyqnlaerlnktplyktvsseav 49 
                 + ++ e+ e V+ +y+  ++ ++++pl+k++++++v
  EFC38568.1 141 TQNPPEQLETVEKYYKDSKKLFDSDPLFKDLAHQKV 176
                 667889************************999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       793  (0.04423); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 2874.34
//
Query:       EFC38569.1  [L=487]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.2e-14   54.3   0.6      3e-14   53.1   0.6    1.7  1  FHA           FHA domain
    8.3e-10   38.9  13.2    1.8e-09   37.8  13.2    1.6  1  zf-RING_2     Ring finger domain
    8.6e-10   38.3   9.5    1.5e-09   37.5   9.5    1.4  1  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
      8e-09   35.2  12.8      8e-09   35.2  12.8    1.8  1  zf-C3HC4_2    Zinc finger, C3HC4 type (RING finger)
    4.1e-08   32.9  13.6      1e-07   31.7  13.6    1.7  1  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
    6.2e-08   32.5  11.4    1.5e-07   31.3  11.4    1.7  1  zf-RING_UBOX  RING-type zinc-finger
    1.4e-07   31.5  14.3    3.2e-07   30.4  14.3    1.7  1  zf-C3HC4_4    zinc finger of C3HC4-type, RING
    2.9e-06   27.0   9.3    6.5e-06   25.9   9.3    1.6  1  Prok-RING_4   Prokaryotic RING finger family 4
    2.1e-05   24.8   0.0    5.7e-05   23.4   0.0    1.7  1  Yop-YscD_cpl  Inner membrane component of T3SS, cytoplasmic d
    4.3e-05   23.4  14.0    0.00014   21.8  14.0    2.0  1  zf-RING_5     zinc-RING finger domain
    4.6e-05   23.6  12.9    0.00026   21.2  12.9    2.3  1  zf-rbx1       RING-H2 zinc finger domain
    0.00061   19.9   0.0     0.0034   17.5   0.0    2.1  2  U-box         U-box domain
     0.0032   17.6  11.0     0.0075   16.4  11.0    1.6  1  zf-RING_10    zinc RING finger of MSL2
     0.0038   17.2   3.6      0.012   15.6   3.6    1.9  1  zf-ANAPC11    Anaphase-promoting complex subunit 11 RING-H2 f
  ------ inclusion threshold ------
      0.032   14.3   0.5      0.032   14.3   0.5    2.1  2  DUF1640       Protein of unknown function (DUF1640)
        4.5    7.1  15.2      0.038   13.8   5.9    2.2  2  zf-RING_4     RING/Ubox like zinc-binding domain
        9.9    6.4  11.3        5.1    7.3   5.1    2.8  2  zf-UDP        Zinc-binding RING-finger


Domain annotation for each model (and alignments):
>> FHA  FHA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.1   0.6   2.9e-17     3e-14       2      68 ..      98     164 ..      97     165 .. 0.93

  Alignments for each domain:
  == domain 1  score: 53.1 bits;  conditional E-value: 2.9e-17
                 EEESSTTSSEETT....STTSTTTEEEEEEETTCEEEEEEEESSSSSEEETTEEESTTSEEEE-TTEEEEE CS
         FHA   2 tiGRssdcdivld....dpsiSrkHalikfdkgsgkvyleDlgSknGtfvNgqrigkgepveLksgdviel 68 
                  iGR +++++++     ++ +Sr+Ha+ik  +   ++++eD gS nGt vNg++i++    +Lk+gd i +
  EFC38569.1  98 NIGRMQTNNVRIFskqqSKFVSRNHAQIKKINA-FTFEIEDKGSMNGTLVNGKKIQT---SKLKHGDLIII 164
                 69*********987776789************9.**********************9...*******9965 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.8  13.2   1.7e-12   1.8e-09       2      44 .]     285     324 ..     284     324 .. 0.87

  Alignments for each domain:
  == domain 1  score: 37.8 bits;  conditional E-value: 1.7e-12
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreClerwlrssstCPlCr 44 
                 +C+IC++ +   + ++l +CgH f++ Cl +wl+++++CPlCr
  EFC38569.1 285 TCCICYNLFV--EPTVL-ECGHNFCKRCLYEWLAKNHSCPLCR 324
                 7****98886..34444.5***********************9 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.5   9.5   1.5e-12   1.5e-09       2      48 ..     283     328 ..     282     330 .. 0.95

  Alignments for each domain:
  == domain 1  score: 37.5 bits;  conditional E-value: 1.5e-12
                 GSB-TTTSSSBS-EEETTEEEEEE-HHHHHHHHHTT-B-TTT--B-- CS
  zf-C3HC4_3   2 deeCviClerprnvvllpCgHlvlCeeCaekllkrkkkCpiCrrpie 48 
                 + +C+iC++   + ++l+CgH  +C++C+ ++l+++++Cp+Cr++ +
  EFC38569.1 283 ELTCCICYNLFVEPTVLECGHN-FCKRCLYEWLAKNHSCPLCRKKLS 328
                 679*******************.********************9976 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2  12.8   7.5e-12     8e-09       2      40 .]     286     323 ..     285     323 .. 0.98

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 7.5e-12
  zf-C3HC4_2   2 CpiCldmlkdpsvvtpCgHvfCqkCilrsLeekneCPlC 40 
                 C iC++ + +p +v +CgH fC+ C+ ++L ++ +CPlC
  EFC38569.1 286 CCICYNLFVEP-TVLECGHNFCKRCLYEWLAKNHSCPLC 323
                 ***********.9************************** PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7  13.6   9.8e-11     1e-07       1      41 []     286     323 ..     286     323 .. 0.98

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 9.8e-11
                 -TTT-S--SS-E.E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepnelleCkHsfCskCirkilksrkkvkCPlC 41 
                 C iC + ++ep+ +leC+H+fC+ C+ ++l   k+ +CPlC
  EFC38569.1 286 CCICYNLFVEPT-VLECGHNFCKRCLYEWLA--KNHSCPLC 323
                 ************.******************..9999**** PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.3  11.4   1.5e-10   1.5e-07       1      39 []     286     321 ..     286     329 .. 0.93

  Alignments for each domain:
  == domain 1  score: 31.3 bits;  conditional E-value: 1.5e-10
  zf-RING_UBOX   1 CpIClelftdPlvlpCGHtFCreClwelskslegafkCP 39 
                   C IC++lf +P+vl+CGH+FC++Cl    ++l ++ +CP
    EFC38569.1 286 CCICYNLFVEPTVLECGHNFCKRCL---YEWLAKNHSCP 321
                   ***********668***********...78899999998 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.4  14.3     3e-10   3.2e-07       1      42 []     286     323 ..     286     323 .. 0.96

  Alignments for each domain:
  == domain 1  score: 30.4 bits;  conditional E-value: 3e-10
  zf-C3HC4_4   1 CPiCldYLekPvsleCGhsfClsCisslqkepdgeqllCplC 42 
                 C iC +++ +P+ leCGh+fC +C++++  ++    ++CplC
  EFC38569.1 286 CCICYNLFVEPTVLECGHNFCKRCLYEWLAKN----HSCPLC 323
                 99****************************99....66***9 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   9.3   6.2e-09   6.5e-06       1      43 [.     286     330 ..     286     333 .. 0.90

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 6.2e-09
  Prok-RING_4   1 CvlCgeqekkailepCgHlvCkeCfdsk..dlssCPlCqrrisks 43 
                  C +C +   ++ +  CgH +Ck+C+ ++  ++ sCPlC++++sk 
   EFC38569.1 286 CCICYNLFVEPTVLECGHNFCKRCLYEWlaKNHSCPLCRKKLSKG 330
                  9999999999*****************9866669*******9875 PP

>> Yop-YscD_cpl  Inner membrane component of T3SS, cytoplasmic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.0   5.4e-08   5.7e-05      10      79 ..      88     162 ..      84     169 .. 0.84

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 5.4e-08
                   -EEEETTEEEEEES-TT-SEE-....--TTS-TT-EEEE.EETTEEEEEE-CESS--EETTEE-SECC--TTSEE CS
  Yop-YscD_cpl  10 aeveLeegevviGsdedcDivL....sDkevsrkhlkLe.veeesvrledlgsrngllvngerveelelrpgdvl 79 
                   +e+ L+e+ + iG+ +++++ +    + k vsr+h++++ +++    +ed+gs ng+lvng+++++++l++gd +
    EFC38569.1  88 KEFFLSEDVINIGRMQTNNVRIfskqQSKFVSRNHAQIKkINAFTFEIEDKGSMNGTLVNGKKIQTSKLKHGDLI 162
                   688899999999999999987733323367********82568899**************************976 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8  14.0   1.3e-07   0.00014       2      44 .]     286     325 ..     278     325 .. 0.96

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 1.3e-07
   zf-RING_5   2 CnkCfeklskeekfyltsCgHifCekClkkllekeavCpiCrk 44 
                 C +C++ +    ++ +++CgH fC++Cl + l+k++ Cp+Crk
  EFC38569.1 286 CCICYNLF---VEPTVLECGHNFCKRCLYEWLAKNHSCPLCRK 325
                 89999999...99****************************97 PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2  12.9   2.5e-07   0.00026      26      55 .]     296     324 ..     276     324 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 2.5e-07
     zf-rbx1  26 pvvlGeCgHaFHlhCiskWlktrkvCPlcr 55 
                 p vl eCgH+F + C+ +Wl ++++CPlcr
  EFC38569.1 296 PTVL-ECGHNFCKRCLYEWLAKNHSCPLCR 324
                 3444.9***********************8 PP

>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       2.2   2.3e+03      26      49 ..     211     233 ..     209     247 .. 0.77
   2 !   17.5   0.0   3.2e-06    0.0034       4      68 ..     283     345 ..     281     349 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 2.2
                 EEHHHHHHHHTT.SSB-TTT-SB- CS
       U-box  26 vdrstiekhllsrdktdPftrepl 49 
                 +d+++i k l s   ++P+ ++  
  EFC38569.1 211 LDQNAIMKSLSS-VISEPVSKQEE 233
                 69999***9999.99999986654 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 3.2e-06
                 GGB-TTT-SB-SSEEEETTTEEEEHHHHHHHHTT.SSB-TTT-SB--GGGSEE-HHHHHHHHHHH CS
       U-box   4 efldpitlelmkdPvilpsgvvvdrstiekhllsrdktdPftrepltqdqlipnlelKekIdefl 68 
                 e+ + i + l+ +P++l  g+++ +  + ++l + ++++P+ r++l++    pn+++    ++++
  EFC38569.1 283 ELTCCICYNLFVEPTVLECGHNFCKRCLYEWLAK-NHSCPLCRKKLSKG-SYPNRSIETILNSYV 345
                 899*******************************.**********9865.467777777666666 PP

>> zf-RING_10  zinc RING finger of MSL2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4  11.0   7.1e-06    0.0075       1      62 [.     284     344 ..     284     351 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 7.1e-06
  zf-RING_10   1 lsCvvCckLLvdPlepkekeCqHyvCrlCvgkkkklkpsCsqCk..dyekyeenkqlrlllqCY 62 
                 l+C++C +L v+P      eC+H+ C++C+ +    + sC+ C+    +    n++++ +l+ Y
  EFC38569.1 284 LTCCICYNLFVEPT---VLECGHNFCKRCLYEWLAKNHSCPLCRkkLSKGSYPNRSIETILNSY 344
                 79********9985...569***********************964223344688888888888 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   3.6   1.2e-05     0.012      51      81 ..     300     327 ..     276     330 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.2e-05
                 TTS-EEEHHHHHHHHHHHSTSSB-TTTSSB- CS
  zf-ANAPC11  51 kckhnfhlhcilkwletetskglcpmcrqtf 81 
                 +c hnf + c+++wl++++s   cp+cr+++
  EFC38569.1 300 ECGHNFCKRCLYEWLAKNHS---CPLCRKKL 327
                 7**************99865...*****976 PP

>> DUF1640  Protein of unknown function (DUF1640)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1       1.2   1.2e+03      21      51 ..     214     244 ..     195     256 .. 0.70
   2 ?   14.3   0.5     3e-05     0.032     117     156 ..     350     389 ..     338     392 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.2
     DUF1640  21 eaimsaltevlneslekvakslvskseleks 51 
                 +aim+ l++v+ e ++k +++ v+    ++s
  EFC38569.1 214 NAIMKSLSSVISEPVSKQEEKSVENISRDIS 244
                 4677777777777777777777765555544 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 3e-05
     DUF1640 117 ireelakleakiqelnnkidrevsalrteiEsvKldviky 156
                  ++e++  e++i+ +++k+d+++++l  +iE++K + ik 
  EFC38569.1 350 CTDEQKLREDRIKLIQQKFDEDLAKLHGMIENAKAKKIKF 389
                 579********************************99996 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   1.5       2.8   2.9e+03      24      31 ..     285     292 ..     262     299 .. 0.74
   2 ?   13.8   5.9   3.6e-05     0.038      19      46 ..     300     326 ..     294     328 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.8
   zf-RING_4  24 iClfCyhr 31 
                  C+ Cy+ 
  EFC38569.1 285 TCCICYNL 292
                 38899985 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 3.6e-05
   zf-RING_4  19 eCgyqiClfCyhrileeeegrCPaCree 46 
                 eCg+++C  C+ + l+ ++  CP Cr++
  EFC38569.1 300 ECGHNFCKRCLYEWLA-KNHSCPLCRKK 326
                 8**************6.79*******96 PP

>> zf-UDP  Zinc-binding RING-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   5.1    0.0048       5.1      16      62 ..     282     329 ..     258     335 .. 0.79
   2 ?    1.5   0.4      0.31   3.3e+02      18      45 ..     430     457 ..     413     471 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0048
      zf-UDP  16 ddvgltedgelFv..acnecafpvcrpcyeyerkdgnqsCPqCktrykr 62 
                  ++ +    +lFv   + ec+   c+ c+ ye    n+sCP C+ + ++
  EFC38569.1 282 SELTCCICYNLFVepTVLECGHNFCKRCL-YEWLAKNHSCPLCRKKLSK 329
                 5555555567888445889******9995.55556677*****998876 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.31
      zf-UDP  18 vgltedgelFvacnecafpvcrpcyeye 45 
                 v+  ++ el +ac++   pv   +   e
  EFC38569.1 430 VNNCTNEELIIACDNLEIPVAYMIVGQE 457
                 7777899***********9987766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (487 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1372  (0.0765241); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.69u 0.37s 00:00:01.06 Elapsed: 00:00:00.55
# Mc/sec: 2650.37
//
Query:       EFC38570.1  [L=526]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.8    8.7   8.7       0.27   12.0   0.7    3.4  4  PMC2NT    PMC2NT (NUC016) domain


Domain annotation for each model (and alignments):
>> PMC2NT  PMC2NT (NUC016) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       0.6   1.1e+04      29      60 ..      49      80 ..      40      96 .. 0.58
   2 ?   -0.8   0.0      0.15   2.6e+03      14      30 ..     280     295 ..     248     346 .. 0.67
   3 ?   -1.5   0.1      0.23   4.1e+03      51      51 ..     404     404 ..     371     448 .. 0.54
   4 ?   12.0   0.7   1.5e-05      0.27      19      64 ..     449     493 ..     438     508 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.6
      PMC2NT 29 ldeqserllslinsllklaaskseisasskle 60
                +++++   l+ +n l +  +s+s+  +ss++e
  EFC38570.1 49 INQEKTSSLNGLNYLYDTDDSESDSGSSSDSE 80
                55555666666666666666666664432222 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.15
      PMC2NT  14 Dldfyrsldpefaksld 30 
                 D++  +sl ++++k +d
  EFC38570.1 280 DYALEKSL-ESLKKTID 295
                 33333444.33333333 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.23
      PMC2NT  51 s 51 
                 +
  EFC38570.1 404 K 404
                 1 PP

  == domain 4  score: 12.0 bits;  conditional E-value: 1.5e-05
      PMC2NT  19 rsldpefaksldeqserllslinsllklaaskseisassklededd 64 
                 r+ d +f+ +++++s+ + + insll+++++ks ++++  l ++++
  EFC38570.1 449 RNQDISFSPRINNNSKSIHRNINSLLSWHKEKSMKHEK-LLLKKQE 493
                 566779**************************999776.3333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (526 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2282  (0.12728); expected 358.6 (0.02)
Passed bias filter:                      501  (0.0279436); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.37s 00:00:01.17 Elapsed: 00:00:00.56
# Mc/sec: 2831.70
//
Query:       EFC38571.1  [L=457]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.6e-41  140.2   0.5    2.1e-40  138.4   0.2    1.9  2  GTP_EFTU     Elongation factor Tu GTP binding domain
    2.3e-22   79.4   0.3    1.3e-21   77.0   0.2    2.3  3  GTP_EFTU_D3  Elongation factor Tu C-terminal domain
    5.7e-06   26.4   0.2    3.7e-05   23.8   0.2    2.2  1  MMR_HSR1     50S ribosome-binding GTPase
    0.00055   20.3   2.7    0.00076   19.8   1.0    2.3  2  GTP_EFTU_D2  Elongation factor Tu domain 2
  ------ inclusion threshold ------
      0.015   15.3   0.1      0.063   13.3   0.0    2.0  2  bMG3         Bacterial alpha-2-macroglobulin MG3 domain
        0.1   12.5   0.7        0.5   10.3   0.4    2.2  2  GTP_EFTU_D4  Elongation factor Tu domain 4


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  138.4   0.2     7e-44   2.1e-40       4     189 ..      29     243 ..      26     303 .. 0.90
   2 ?   -0.4   0.0      0.23   6.8e+02     113     148 ..     374     409 ..     367     439 .. 0.76

  Alignments for each domain:
  == domain 1  score: 138.4 bits;  conditional E-value: 7e-44
                 EEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH...HHHST............HCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHHH CS
    GTP_EFTU   4 rnigiighvDhGKtTLtdrLlyktgaiskkgeka...eeerv............lDtlkeErergiTiksaaisleketkkylinliDtPGHvdFskev 87 
                 +n++++ghvD+GK+TL++r+l +tg+i+++  ++   e  +             +D  ++E+++g Ti++  +++e  t+k++++++D+PGH+ ++ ++
  EFC38571.1  29 LNVIFLGHVDAGKSTLSGRILLDTGMIDDRVIEKfkmE--AKennreswyiayiMDCSEDEKAKGKTIEVGRAHFE--TQKKRYTILDAPGHKAYVPNM 123
                 79***************************999996431..3356789*****************************..********************* PP

                 HHHHHT-SEEEEEEETTTB.......STHHHHHHHHHHHHTTTE.EEEEEESCGST.....HHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEE CS
    GTP_EFTU  88 irglrvlDgavlvvdaveG.......vepqteevlrlalkegvp.iivfiNKmDrl.....kaelkeiveevkqklsrkeeklekygekgekevpvvfg 173
                 i ++ ++D+ +lv++a++G          qt e+  l +++gv  +iv++NK+D +     k +++eiv++v+ +l       + +g + +++v+++++
  EFC38571.1 124 ISATTQADVGILVISARKGefeagleKGGQTMEHTVLSKTLGVDqLIVVVNKIDDPsvakdKVRYDEIVTKVSATL-------KGVGWNLKTQVQFIPI 215
                 ************************9999****************************99998889999999999888.......5555555579****** PP

                 BTTTTBTHH............HHHHHHH CS
    GTP_EFTU 174 Salkgegvk............tllealv 189
                  al+g++++            +l+eal+
  EFC38571.1 216 DALTGQNISsrnlnvpwysgpSLIEALD 243
                 ******9987777777777775555555 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.23
                 HHHHHHHHTTTEEEEEEESCGST.HHHHHHHHHHHHH CS
    GTP_EFTU 113 evlrlalkegvpiivfiNKmDrl.kaelkeiveevkq 148
                  +++ a  e + +  +i KmD+  ++ l ++++ v++
  EFC38571.1 374 MHIHTAM-ETITLTKLISKMDKKtGKPLAQVPKFVQN 409
                 5555444.67889999*****9866777777666665 PP

>> GTP_EFTU_D3  Elongation factor Tu C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       2.9   8.7e+03      27      45 ..     119     137 ..     113     168 .. 0.60
   2 ?   -2.0   0.0       1.4   4.3e+03      97     109 ..     266     278 ..     260     279 .. 0.90
   3 !   77.0   0.2   4.2e-25   1.3e-21       3     111 ..     345     453 ..     344     454 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.9
                  -EEEEESSS-EEEEEEEEE CS
  GTP_EFTU_D3  27 YrpvlyirtadvtgkvveL 45 
                  Y p +   t++  + +  +
   EFC38571.1 119 YVPNMISATTQADVGILVI 137
                  5566665555555533333 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.4
                  ECTTCEEEEEEEE CS
  GTP_EFTU_D3  97 ReggrTvaaGvvt 109
                  R++g Tv  G+v 
   EFC38571.1 266 RDKGCTVVLGKVL 278
                  9*********996 PP

  == domain 3  score: 77.0 bits;  conditional E-value: 4.2e-25
                  EEECCEEEEEEESSS...SS-BSTT-EEEEESSS-EEEEEEEEEEECCSSTTSB-BSS-SSCCSTT-CEEEEEEECCEEEE--TTTHCCCCEEEEECT CS
  GTP_EFTU_D3   3 kphtkfeAqvyileke.rhtpitagYrpvlyirtadvtgkvveLlskldkktekvsekkpefvkpGdnvivevelikpialekgseypqlGrFaiReg 99 
                  +p+++f  +  il       +i +g++  ++i+ta +t + ++L+sk+dkkt+k   + p+fv++ d+++   +l+kpi++ek++  + +GrF +R  
   EFC38571.1 345 EPVQEFIGSFHILDSSeHVDIISSGFSTNMHIHTAMETITLTKLISKMDKKTGKPLAQVPKFVQNKDTAEGVFRLEKPICIEKFESLNAMGRFVLRS- 441
                  57899********99845678899************************************************************************7. PP

                  TCEEEEEEEEEE CS
  GTP_EFTU_D3 100 grTvaaGvvtei 111
                   rT+a+G v+++
   EFC38571.1 442 DRTIAVGRVKKV 453
                  68********99 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.2   1.2e-08   3.7e-05       1     114 []      30     175 ..      30     175 .. 0.67

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 1.2e-08
                 EEEEEESTTSSHHHHHHHHH..................T.............STEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinalt..................g.............ekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgk 68 
                 +v+++G+  +GKStL  +++                  +             + ++ ++ +g+T+++ ++++++++k+++++D pG  +    +  + +
  EFC38571.1  30 NVIFLGHVDAGKSTLSGRILldtgmiddrviekfkmeaKennreswyiayimDCSEDEKAKGKTIEVGRAHFETQKKRYTILDAPG--H----KAYVPN 122
                 5899***************9777777666666665555055566666655434678889999999999999999999*********..5....345777 PP

                 HHHHHHCTSEEEEEEETT........TTCSHHHHHHHHHHHHH...TTSEEEEEEES CS
    MMR_HSR1  69 aflaleeadlillvvdas........eeklkpldeeleellee...akkplilvlnk 114
                  + a  +ad+ +lv++a+        e    +  +++e +  +     ++li+v+nk
  EFC38571.1 123 MISATTQADVGILVISARkgefeaglE----KGGQTMEHTVLSktlGVDQLIVVVNK 175
                 77777779*******999555533321....22222222221122233446777776 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       2.3     7e+03      27      39 ..     187     199 ..     165     203 .. 0.71
   2 !   19.8   1.0   2.5e-07   0.00076       2      73 ..     271     337 ..     270     338 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.3
                  TSEEEEEEEEEEE CS
  GTP_EFTU_D2  27 skkeivtrissle 39 
                    +eivt++s+++
   EFC38571.1 187 RYDEIVTKVSATL 199
                  2345888888876 PP

  == domain 2  score: 19.8 bits;  conditional E-value: 2.5e-07
                  EEEEEEEEESEEETTEEEEEECTCTTSEEEEEEEEEEEEETEEESEEETTSEEEEEEEESSCCSGSSTTCEE CS
  GTP_EFTU_D2   2 tvalgrvysGtlkkGdevrilgndtskkeivtrissletfhededeavaganaGvivaikgledaiivGdtl 73 
                  tv+lg+v sG++k G++v++++n     + v+++ +l  ++ +    v+ a   v + +kg +d i  G t+
   EFC38571.1 271 TVVLGKVLSGQIKIGQKVVVMPN-----KCVCEVIALKSHEINIHGGVVSAGENVELYLKGDDDNIASGHTV 337
                  89******************775.....45788888888866666665555555555566666666666666 PP

>> bMG3  Bacterial alpha-2-macroglobulin MG3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   2.1e-05     0.063      35      86 ..      80     138 ..      78     146 .. 0.91
   2 ?   -2.6   0.0       1.9   5.8e+03       8      25 ..     162     179 ..     160     184 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.1e-05
        bMG3  35 lldkkgevlaegtTDaqGvarfaallar.......gkegaapylvsArkdedlaflkld 86 
                 ++d+++++ a+g+T + G+a+f+++++r       g+++  p ++sA++++d+ +l ++
  EFC38571.1  80 IMDCSEDEKAKGKTIEVGRAHFETQKKRytildapGHKAYVPNMISATTQADVGILVIS 138
                 5799999******************999*******9*****************999875 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.9
        bMG3   8 aklgrdkllvwvtsLdsg 25 
                   lg d+l v+v+++d+ 
  EFC38571.1 162 KTLGVDQLIVVVNKIDDP 179
                 567889999***999985 PP

>> GTP_EFTU_D4  Elongation factor Tu domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.84   2.5e+03       2      27 ..     114     138 ..     113     149 .. 0.74
   2 ?   10.3   0.4   0.00017       0.5      18      73 ..     271     327 ..     259     338 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.84
                  -CEEEEEEEEEEETCCCEEEEEEEEE CS
  GTP_EFTU_D4   2 PgkikilpgvvfrrsdpaivGvevlg 27 
                  Pg++ ++p+++     +a vG+ v++
   EFC38571.1 114 PGHKAYVPNMISAT-TQADVGILVIS 138
                  89999999999765.45667777764 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00017
                  CEEEEEEEEEEEEETT-EEEETTE.EEEEEEEEEETTEEES..EEETT-EEEEEEESS CS
  GTP_EFTU_D4  18 paivGvevlgGvikpgvklikedGrevGeilqiqdkgkkle..eakaGqevaisiegk 73 
                   ++ G +vl+G+ik g k++    + v e+ ++++++ +++  +++aG++v + ++g+
   EFC38571.1 271 TVVLG-KVLSGQIKIGQKVVVMPNKCVCEVIALKSHEINIHggVVSAGENVELYLKGD 327
                  58899.*********************************9755789999999888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (457 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       457  (0.0254894); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.42
# Mc/sec: 3301.54
//
Query:       EFC38572.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-41  142.4  19.7    1.6e-41  142.1  19.7    1.1  1  ABC2_membrane    ABC-2 type transporter
    5.5e-15   56.1   0.2    2.6e-14   53.9   0.1    2.0  2  ABC_tran         ABC transporter
    2.9e-07   29.9   9.6    3.9e-07   29.5   9.6    1.2  1  ABC2_membrane_3  ABC-2 family transporter protein
    7.4e-05   22.7   0.1     0.0002   21.3   0.1    1.7  1  RsgA_GTPase      RsgA GTPase
    0.00017   20.6   0.1       0.03   13.2   0.0    2.7  3  AAA_35           AAA-like domain
     0.0011   19.4   0.1      0.003   17.9   0.1    1.8  1  AAA_16           AAA ATPase domain
     0.0094   15.7   0.0       0.02   14.7   0.0    1.5  1  AAA_30           AAA domain
  ------ inclusion threshold ------
      0.022   14.9   0.1      0.071   13.3   0.1    1.9  1  AAA_33           AAA domain
       0.03   14.6   0.0       0.11   12.8   0.0    2.0  2  AAA_22           AAA domain
      0.039   14.5   0.1        0.1   13.1   0.0    1.9  2  AAA_18           AAA domain
       0.04   13.7   0.0      0.081   12.7   0.0    1.5  1  AAA_21           AAA domain, putative AbiEii toxin, Type IV T
      0.076   13.1   0.2       0.18   11.9   0.2    1.6  1  MMR_HSR1         50S ribosome-binding GTPase
      0.079   12.8   0.1       0.17   11.7   0.1    1.5  1  BCDHK_Adom3      Mitochondrial branched-chain alpha-ketoacid 
       0.11   13.0   0.1       0.47   10.9   0.0    1.9  2  AAA_23           AAA domain
       0.11   12.4   0.0       0.24   11.3   0.0    1.5  1  Rad17            Rad17 P-loop domain
       0.14   12.4   0.1       0.27   11.5   0.1    1.4  1  AAA_28           AAA domain
       0.15   11.8   0.1        0.4   10.4   0.1    1.7  1  IstB_IS21        IstB-like ATP binding protein
       0.16   11.5   0.0       0.27   10.8   0.0    1.3  1  cobW             CobW/HypB/UreG, nucleotide-binding domain
       0.16   11.6   0.3       0.77    9.4   0.1    2.2  3  AAA_24           AAA domain
       0.17   11.4   0.2       0.42   10.1   0.1    1.7  2  AAA_25           AAA domain
       0.18   11.1   0.0       0.34   10.2   0.0    1.4  1  Zeta_toxin       Zeta toxin


Domain annotation for each model (and alignments):
>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.1  19.7   1.8e-44   1.6e-41       2     194 ..     257     451 .]     256     451 .] 0.98

  Alignments for each domain:
  == domain 1  score: 142.1 bits;  conditional E-value: 1.8e-44
  ABC2_membrane   2 qikallkreflqrwrdpslgllwrliqplllalvfgtvfgnlg.nsedglnrpgllffsvlflafsaltsvapvferergvlerelvsplyslsay 96 
                    q++++l+r+fl+ +r+++ + ++rl+q + +a+++g+++ +l+ +++++++r+g+lffsv +++f +l+s+ +v   +++v++re+ ++ly++s+ 
     EFC38572.1 257 QFFVVLMRSFLNTIRNKAVT-MARLFQQVSTAFLLGLIYLRLKnDQTGVQDRLGVLFFSVSNMFFGSLSSSLNVLLGDKPVFNRERGAKLYRVSSW 351
                    9*******************.99********************667777799******************************************** PP

  ABC2_membrane  97 vlakvlvelpvsllqalifllivyflvgldls..rfflflllllltalaasslgllisalapsfedasqlaslvllpllllsGffipidsmpkwlq 190
                    ++akv++++p  l++ l+f +i yf++gl+ s  rf++fll+  +++l++ +lg++i++++p++ +a  +++++ ++l+l++Gf+ ++d++p+++ 
     EFC38572.1 352 YVAKVIADIPSVLFFPLLFGCILYFWIGLNGSidRFLMFLLIQAILGLTGQGLGIAIASISPNASVAFSIMPVISTILMLFGGFYLNLDNVPVYFV 447
                    ************************************************************************************************ PP

  ABC2_membrane 191 wiay 194
                    wi++
     EFC38572.1 448 WIYW 451
                    ***8 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.9   0.1     3e-17   2.6e-14       8     103 ..       5     111 ..       1     122 [. 0.89
   2 ?   -0.8   0.0       2.3   1.9e+03      67      96 ..     199     228 ..     185     268 .. 0.64

  Alignments for each domain:
  == domain 1  score: 53.9 bits;  conditional E-value: 3e-17
                 EETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH...............HHHTCHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...............xxxxxxxxxxxx RF
    ABC_tran   8 lkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren...............esdeeiekalsk 91 
                 +k+ge++ai+G++GaGK++Ll++l++ +k   Geil +g+++ +     +++ +++++q++ l  +ltvre+               e+ ++++ ++++
  EFC38572.1   5 VKPGEVLAIMGPSGAGKTSLLNILSQRVKASGGEILANGQHVGK----AFKSISAFVQQDDVLLGNLTVRETlrytamlrlgnvsmkERMKRVDSLIQE 99 
                 89*************************************99998....999999999999************************88877788999999* PP

                 STTGGTTCBGES CS
                 xxxxxxxxxxxx RF
    ABC_tran  92 lglkelkdtvvk 103
                 lgl+ ++dt  +
  EFC38572.1 100 LGLSRVADTLPT 111
                 *99998887664 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 2.3
                 S--S-TTSBHHHH.....HHHTCHHHHHHHSTTGG CS
                 xxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxx RF
    ABC_tran  67 epqlfpeltvren.....esdeeiekalsklglke 96 
                 +p l +e           e++++ie++ls+++ + 
  EFC38572.1 199 NPALVEE-----GkttkvEQNQRIETILSNYSENF 228
                 3333333.....14444477777888877776655 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.5   9.6   4.5e-10   3.9e-07     114     300 ..     264     449 ..     187     451 .] 0.74

  Alignments for each domain:
  == domain 1  score: 29.5 bits;  conditional E-value: 4.5e-10
  ABC2_membrane_3 114 kailnalns.llqqlnasalvlqseatstsaninvestqleeelsnvasflvgliliil.ifitasfiavsi......veEkesrikelqlvsg 199
                       ++ln++ +   ++        + ++ st++ +++  + l++++++v++ l +l++ ++ +f+++++ + ++      v+ +e+++k   ++s 
       EFC38572.1 264 RSFLNTIRNkAVTMAR------LFQQVSTAFLLGLIYLRLKNDQTGVQDRLGVLFFSVSnMFFGSLSSSLNVllgdkpVFNRERGAKLYRVSS- 350
                      4555555553333322......345678889999999999*************88888878888888888888888889********877666. PP

  ABC2_membrane_3 200 vsplqywlskilgdflvyllqlllilll...afglgipfg..nlglllllfllfglayialgyllsslfknsetaqilifivilllsgffgglf 288
                            +++k+++d    l++ ll+  +   ++g  ++ +   ++ +ll   + gl+   lg ++ s++ n++ a++++++++ +l++ fgg++
       EFC38572.1 351 -----WYVAKVIADIPSVLFFPLLFGCIlyfWIG--LNGSidRFLMFLLIQAILGLTGQGLGIAIASISPNASVAFSIMPVISTILML-FGGFY 436
                      .....**********9999998877654234777..444453888888*****************************88888885555.55555 PP

  ABC2_membrane_3 289 p.ledlpsalkwi 300
                      + l+++p ++ wi
       EFC38572.1 437 LnLDNVPVYFVWI 449
                      55***99999998 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.1   2.3e-07    0.0002     100     139 ..       9      45 ..       4      58 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 2.3e-07
                  SEEEEECSTTSSHHHHHHHHCTT-----S----------- CS
  RsgA_GTPase 100 ktsvlvGqSGvGKStLinallpelelktgevseklgrGkh 139
                  ++ +++G+SG+GK++L+n l ++ +++ ge+ +   +G+h
   EFC38572.1   9 EVLAIMGPSGAGKTSLLNILSQRVKASGGEILA---NGQH 45 
                  7899*******************9999999865...3555 PP

>> AAA_35  AAA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.0   3.5e-05      0.03      28      61 ..       5      38 ..       1      59 [. 0.79
   2 ?    4.3   0.0     0.017        15      44      82 ..     117     155 ..     111     162 .. 0.89
   3 ?   -2.6   0.0       2.2   1.9e+03     225     256 ..     192     223 ..     183     229 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.5e-05
      AAA_35 28 ekpGalirikapkkmGKtSLlarilakakqqgyk 61
                 kpG+++ i +p+  GKtSLl+ + +++k++g +
  EFC38572.1  5 VKPGEVLAIMGPSGAGKTSLLNILSQRVKASGGE 38
                69*******************9988888777654 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.017
      AAA_35  44 KtSLlarilakakqqgyktvsldlqladkeilsdldkfl 82 
                 KtSL      ++ +q+ +tv+l +++  ++i++++d++l
  EFC38572.1 117 KTSLSVINTINKLAQNGRTVVLTIHQPRSDIFQSFDRLL 155
                 99998877778888999*******************997 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 2.2
      AAA_35 225 LmslvgGhPylvrlalyhlaqeeltleellee 256
                 +m+lv  +P+lv+    + ++++  +e++l++
  EFC38572.1 192 FMDLVTENPALVEEGKTTKVEQNQRIETILSN 223
                 79999999999999999999999999999987 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.1   3.6e-06     0.003      25      63 ..       9      46 ..       3     159 .. 0.67

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 3.6e-06
      AAA_16 25 elvllsGesGvGKsslvrellralekdggiflrgkcdql 63
                e++ + G+sG GK+sl++ l ++++++g   + ++ ++ 
  EFC38572.1  9 EVLAIMGPSGAGKTSLLNILSQRVKASG-GEILANGQHV 46
                7899******************999994.4444444444 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   2.3e-05      0.02      18      50 ..       8      40 ..       2      98 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2.3e-05
      AAA_30 18 drvavltGpAGtGKttalkalreaweaaggrvi 50
                  v ++ Gp G+GKt +l+ l + ++a+gg+++
  EFC38572.1  8 GEVLAIMGPSGAGKTSLLNILSQRVKASGGEIL 40
                45899***********************86664 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   8.4e-05     0.071       2      98 ..      11     103 ..      10     120 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 8.4e-05
      AAA_33   2 vllvGlpGsGKstlaerl...lkklgavllssdtlrrrlfgtdqqsktdytrvldrlyqilnelarkalsagrnvildatnlsrrer.arflklarrlg 96 
                 + + G++G+GK+ l+  l   +k+ g+++l+  +   + f    +s++   +  d l     + ++ + + +++++l+ +n+s +er +r+++l ++lg
  EFC38572.1  11 LAIMGPSGAGKTSLLNILsqrVKASGGEILANGQHVGKAF----KSISAFVQQDDVLL----GNLTVRETLRYTAMLRLGNVSMKERmKRVDSLIQELG 101
                 6789**********99994445666699998776555555....67766555554444....5557788999***********866647*******999 PP

      AAA_33  97 vp 98 
                   
  EFC38572.1 102 LS 103
                 65 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   0.00013      0.11       6      29 ..       9      32 ..       5     140 .. 0.84
   2 ?   -1.3   0.0       2.9   2.5e+03      44      63 ..     179     198 ..     156     236 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 0.00013
      AAA_22  6 gilvvtGesGtGKTtllrrlleql 29
                 +l+++G+sG+GKT ll+ l ++ 
  EFC38572.1  9 EVLAIMGPSGAGKTSLLNILSQRV 32
                6799************99887775 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 2.9
      AAA_22  44 fvtlpsstsskdllrellra 63 
                  +++p+  +++d++ +l+ +
  EFC38572.1 179 GYDCPEAFNPADFFMDLVTE 198
                 68999999999998888765 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   0.00012       0.1       2      27 ..      12      45 ..      11     142 .. 0.74
   2 ?   -2.1   0.0         6   5.2e+03      24      42 ..     233     255 ..     193     286 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 0.00012
      AAA_18  2 lltGtpGvGKttlakeLskrl.gf.......gvn 27
                +++G++G+GKt+l + Ls+r  ++       g++
  EFC38572.1 12 AIMGPSGAGKTSLLNILSQRVkASggeilanGQH 45
                599***************9973336666666333 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 6
      AAA_18  24 f....gvnlrdvakenglllevd 42 
                 +    gvn  ++ ++n +  +++
  EFC38572.1 233 SakrdGVNMEHLTRKNKYTSGWF 255
                 02223455555555555444444 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   9.5e-05     0.081       3      80 ..      12      83 ..      10     104 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 9.5e-05
      AAA_21  3 vliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldlydpeipfefeieeflsqgvryryglrler 80
                ++ Gp g+GK++LL +l       + v+ ++ e   +g+  + ++++ +    +++++  ++++ +  ry+  lrl++
  EFC38572.1 12 AIMGPSGAGKTSLLNIL------SQRVKASGGEILANGQHVGKAFKSISAFVQQDDVLLGNLTVRETLRYTAMLRLGN 83
                789**************......7788888888888888888888888888888888888878878777777777776 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.2   0.00021      0.18       2      24 ..      11      34 ..      10      52 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00021
                EEEEESTTSSHHHHHHHHHTS.TE CS
    MMR_HSR1  2 vaivGrpNvGKStLinaltge.ka 24
                 ai+G + +GK++L+n l+++ ka
  EFC38572.1 11 LAIMGPSGAGKTSLLNILSQRvKA 34
                58****************987444 PP

>> BCDHK_Adom3  Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1    0.0002      0.17      47     108 ..     210     285 ..     205     308 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.0002
  BCDHK_Adom3  47 glvenpsvkkvkdwYaqsfeellelpkp..elee............nekftelLekikkrHddvvttlaqGvlelk 108
                  ++ +n+ ++++ ++Y + feel + ++   ++e+            ++ f+ l+++++++ ++   t+a+ +++++
   EFC38572.1 210 KVEQNQRIETILSNYSENFEELASAKRDgvNMEHltrknkytsgwfSQFFVVLMRSFLNTIRNKAVTMARLFQQVS 285
                  6899*********************997433444888999999999999999999999999999999999999887 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00055      0.47      22      39 ..      11      28 ..       6      31 .. 0.88
   2 ?   -1.5   0.0       3.5   2.9e+03      88     107 ..     215     234 ..     194     299 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00055
      AAA_23 22 tlItGpNGaGKTTildAi 39
                 +I Gp GaGKT++l+ +
  EFC38572.1 11 LAIMGPSGAGKTSLLNIL 28
                579************976 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 3.5
      AAA_23  88 rsiererelskkkgkttkka 107
                 ++ie   ++++++ ++   a
  EFC38572.1 215 QRIETILSNYSENFEELASA 234
                 12222222222222222222 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00028      0.24      45      71 ..       8      34 ..       4      80 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00028
       Rad17 45 kriLLisGPsGCgkstvvkvLskelgi 71
                 ++L i GPsG gk+  +++Ls+    
  EFC38572.1  8 GEVLAIMGPSGAGKTSLLNILSQRVKA 34
                56899*****************87655 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   0.00032      0.27       3      22 ..      12      31 ..      10      47 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00032
      AAA_28  3 vitGgestGKTtlleaLaar 22
                +i+G++++GKT+ll+ L++r
  EFC38572.1 12 AIMGPSGAGKTSLLNILSQR 31
                79****************88 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.1   0.00047       0.4      43      71 ..       4      32 ..       1      45 [. 0.83

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00047
   IstB_IS21 43 fiekkenivllGpsGvGKshlaialgvea 71
                f++  e ++++GpsG+GK+ l   l+++ 
  EFC38572.1  4 FVKPGEVLAIMGPSGAGKTSLLNILSQRV 32
                89999**************9987777665 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00032      0.27       2      28 ..      10      36 ..       9      60 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00032
                EEEEEESTTCCHHHHHHHHHCT--SS- CS
        cobW  2 vtvltGflGsGKTtLlnhllenraglk 28
                v+ + G+ G+GKT+Lln l ++ +   
  EFC38572.1 10 VLAIMGPSGAGKTSLLNILSQRVKASG 36
                67899***********98886655555 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1    0.0009      0.77       5      22 ..      11      28 ..       8      38 .. 0.86
   2 ?   -3.6   0.0       8.7   7.4e+03     178     195 ..     101     118 ..      86     120 .. 0.76
   3 ?   -1.8   0.0       2.5   2.1e+03     111     131 ..     122     142 ..     116     149 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0009
      AAA_24  5 iliyGpsgiGKTtlakel 22
                ++i+Gpsg+GKT+l++ l
  EFC38572.1 11 LAIMGPSGAGKTSLLNIL 28
                79***********99876 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 8.7
      AAA_24 178 vgervlktsksesidaKn 195
                 +  rv +t ++++ daK+
  EFC38572.1 101 GLSRVADTLPTTGLDAKT 118
                 567999999999999997 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 2.5
      AAA_24 111 frrllkklqelrknvifiahe 131
                 ++++++kl + + +v+++ h+
  EFC38572.1 122 VINTINKLAQNGRTVVLTIHQ 142
                 5667777777777****9997 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.1    0.0005      0.42      27      51 ..       2      26 ..       1      48 [. 0.85
   2 ?   -3.0   0.0       5.4   4.6e+03     167     189 ..     121     143 ..     115     145 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.0005
      AAA_25 27 kgllpagelallaGapgtGKttlal 51
                 g++  ge+ +++G++g+GKt l+ 
  EFC38572.1  2 SGFVKPGEVLAIMGPSGAGKTSLLN 26
                689999***************9985 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 5.4
      AAA_25 167 alvealeriarrtgaavllvhHv 189
                 ++++ ++++a++ +  vl +h++
  EFC38572.1 121 SVINTINKLAQNGRTVVLTIHQP 143
                 57889999987777777777765 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   0.00039      0.34      21      88 ..      13      80 ..       6      89 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00039
  Zeta_toxin 21 lgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPeyeeilkadpkkaseltqkdaselvekll 88
                + G +GAGK++l++ l +++++ g+ +  ++ ++ + +   ++  ++d+    +lt +++ + +++l+
  EFC38572.1 13 IMGPSGAGKTSLLNILSQRVKASGGEILANGQHVGKAFKSISAFVQQDDVLLGNLTVRETLRYTAMLR 80
                55889****************99999999999999999999999999999999999999888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       744  (0.041497); expected 358.6 (0.02)
Passed bias filter:                      545  (0.0303977); expected 358.6 (0.02)
Passed Vit filter:                       104  (0.00580066); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              21  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 2618.47
//
Query:       EFC38573.1  [L=739]
Description: hypothetical protein NAEGRDRAFT_59473 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.7e-13   48.3   1.4    2.3e-12   47.1   0.2    2.4  2  DRMBL        DNA repair metallo-beta-lactamase
     0.0028   17.7   3.1       0.45   10.5   1.9    2.3  2  Lactamase_B  Metallo-beta-lactamase superfamily
     0.0097   15.8   0.0      0.033   14.1   0.0    1.9  1  RMMBL        Zn-dependent metallo-hydrolase RNA specificity d


Domain annotation for each model (and alignments):
>> DRMBL  DNA repair metallo-beta-lactamase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.1   0.2   3.8e-16   2.3e-12       6     107 ..     280     366 ..     277     369 .. 0.77
   2 ?   -3.5   0.1       1.9   1.1e+04       7      32 ..     690     716 ..     687     725 .. 0.63

  Alignments for each domain:
  == domain 1  score: 47.1 bits;  conditional E-value: 3.8e-16
       DRMBL   6 llttdpseaqihlvslkklekeklekylkalkekfdsvlafrPtGWtkkekkkkdlekikessksrekisiyrvpYSeHSSfrELkefvkslkpkkiip 104
                 l+t dp++ +i + s k+++ +++ ++   +     + ++++P+GW+  + k+ +++             iyrvpYS HSS++E+ efv+ lkpk++++
  EFC38573.1 280 LFTCDPKQGRIFVKSKKEVNMRSIIEHKRIFG---ATTVGIIPSGWSSAQLKDPTSQ------------LIYRVPYSLHSSYSEIIEFVSTLKPKNVYS 363
                 56777777777776666665555555554444...7899********9997433333............6***************************** PP

       DRMBL 105 tVn 107
                 t +
  EFC38573.1 364 TSK 366
                 965 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.9
       DRMBL   7 lttdpseaqihlvslkkle.kekleky 32 
                 +  d+s   ++l++++k +  ++l+k 
  EFC38573.1 690 ISWDDSDEDVKLIPHQKNKtSQTLHKT 716
                 666778888888888877634444443 PP

>> Lactamase_B  Metallo-beta-lactamase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   1.9   7.5e-05      0.45      49      61 ..      24      36 ..      24      41 .. 0.93
   2 !    5.9   0.0    0.0019        11     131     162 ..     159     190 ..     155     251 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 7.5e-05
                 E-SBSSHHHHTTG CS
  Lactamase_B 49 ilTHlHlDHiGgl 61
                 +lTHlH+DH+Ggl
   EFC38573.1 24 LLTHLHTDHTGGL 36
                 69**********8 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0019
                  TSCCEEEEEETTCCEEEECTTTSSHHCCCCCC CS
  Lactamase_B 131 hghghgvveygggkvlftGDallagetgridl 162
                  +g++ + +e   g+vlftGD+ + + ++  ++
   EFC38573.1 159 PGSIMFLLEGYFGNVLFTGDFRYDARILQAPC 190
                  899999999999***********999888887 PP

>> RMMBL  Zn-dependent metallo-hydrolase RNA specificity domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.0   5.5e-06     0.033       8      35 ..     335     362 ..     332     364 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 5.5e-06
       RMMBL   8 ieeidfSgHadknellelirklkprnvi 35 
                 i+ + +S H+ ++e++e++++lkp+nv+
  EFC38573.1 335 IYRVPYSLHSSYSEIIEFVSTLKPKNVY 362
                 788999********************85 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (739 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       753  (0.041999); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.28s 00:00:00.92 Elapsed: 00:00:00.46
# Mc/sec: 4822.37
//
Query:       EFC38574.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       930  (0.0518713); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 2015.53
//
Query:       EFC38575.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.042   14.0   0.1        3.4    7.8   0.0    2.7  2  DNA_ligase_IV  DNA ligase IV


Domain annotation for each model (and alignments):
>> DNA_ligase_IV  DNA ligase IV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0    0.0049        87      20      30 ..     162     172 ..     159     176 .. 0.77
   2 ?    7.8   0.0   0.00019       3.4      22      33 ..     183     194 ..     182     195 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.0049
  DNA_ligase_IV  20 tdeeqLKevFn 30 
                    +  +qLK+vF 
     EFC38575.1 162 VKSHQLKDVFP 172
                    5678******6 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00019
  DNA_ligase_IV  22 eeqLKevFnrId 33 
                     ++LKe+F++Id
     EFC38575.1 183 SDSLKEIFSKID 194
                    579********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       857  (0.0477997); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.26s 00:00:00.72 Elapsed: 00:00:00.41
# Mc/sec: 2344.36
//
Query:       EFC38576.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.5e-43  147.9   0.1    5.8e-43  147.2   0.1    1.3  1  Pyr_redox_2    Pyridine nucleotide-disulphide oxidoreductase
    1.7e-26   92.6   0.0    3.1e-26   91.8   0.0    1.5  1  Pyr_redox_dim  Pyridine nucleotide-disulphide oxidoreductase,
    1.5e-10   41.4   0.1    1.5e-10   41.4   0.1    1.9  2  Pyr_redox      Pyridine nucleotide-disulphide oxidoreductase
    1.3e-06   27.9   0.1    1.3e-06   27.9   0.1    1.5  2  Pyr_redox_3    Pyridine nucleotide-disulphide oxidoreductase
  ------ inclusion threshold ------
      0.011   15.6   0.0      0.025   14.5   0.0    1.6  1  3HCDH_N        3-hydroxyacyl-CoA dehydrogenase, NAD binding d
      0.054   12.5   0.0        8.1    5.3   0.0    2.8  3  Glucokinase    Glucokinase
      0.085   11.9   0.0        2.9    6.9   0.0    2.3  2  GIDA           Glucose inhibited division protein A


Domain annotation for each model (and alignments):
>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  147.2   0.1   2.3e-46   5.8e-43       1     283 [.      14     340 ..      14     358 .. 0.89

  Alignments for each domain:
  == domain 1  score: 147.2 bits;  conditional E-value: 2.3e-46
                  CSEEEE--SHHHHHHHHHHHHHTS-EEEEE...TTHCHHHCSHHHHCHHHHHHHHHHHHH................................HHHHCH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxx................................xxxxxx RF
  Pyr_redox_2   1 kdvvviGgGpAGlaaaltlaqagakvtlve...legtclnggcllskallgvaedaeias................................evvkkl 63 
                  +d++viG+G++  ++ + + ++g+ v+l+e   l+gtcln+gc++sk l + ae a+ ++                                + +++ 
   EFC38576.1  14 YDIIVIGAGAGLGKLGRPATEYGYSVALCEndkLGGTCLNRGCIPSKMLIHPAEVANNIEeahrfeidvkkkensddldydirfsemvsrvcKTIDEE 111
                  69*******999999999999********9999**********************999999****************************999777777 PP

                  HHH.CCCCHCCTCEEEEESC.EEEEETEEEC....TCEEEEEESEEEE---EEE-BC..TCTTC.TTBEECCSECHHHHHHCCSS-TSEEEEES-SHH CS
                  xxx.xxxxxxxxxxxxxxxx.xxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2  64 nqg.ielllgeevvkidpgk.kkvklekkke....gdeekiaydklvlAtGssprdl..gipGvaenvgklvrtldsaealklkllpkrivvvGgGyi 153
                  + + i ++ ++++++   g+ ++++ e +++    +d+  i++d++++A G+++ dl   i+G+ +++     +++  eal+ +++ k+++v+G+Gyi
   EFC38576.1 112 SDSiIPRVEANQKLDWFVGQtGRFVGERTVQvgspEDNVVITADRVFVACGARALDLskEIEGL-DKT----PYMTYREALRNQKRFKSLIVIGAGYI 204
                  888344444455999999999999999888899998999******************99999**.444....678999999999999*********** PP

                  HHHHHHHHHHHT-EEEEEESSSSSSTTS-HHHHHHHHHHHHHT.TEEEEESCEEEEEEETTE..EEE.EEETTSCE....EEESEEEE-S-EEES-HH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxx..xxx.xxxxxxxx....xxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 154 GvElAaalaklgkevtlveardrllraldkelsaaleealeke.Gvevklgtsvkeidgnge..kle.vvledgee....idadlvvvavGvrpstel 243
                  ++ElA ++a+ g ++ +   r+ +l+  d+e++++  +++ k+ +++v  g ++ +++ +++   l+    +d+++    + a+ ++va+Gv p+t++
   EFC38576.1 205 ATELAHFFASTGTKTNI-FVRSGFLKHEDEEVQKEFDRVFSKKkNINVIKGMKILKARYENDefVLTySNPSDESSgtieVRAEGLLVAAGVVPNTDI 301
                  **************995.556899999*************9999**************999977666434444444788999**************** PP

                  CS.HCCT-EEEETTEEE--TTSBE.SSTTEEE-GGGCTECCS CS
                  xx.xxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 244 le.eklglelderggivvdeflrt.nvpgiyaiGDvaggkgg 283
                  l+ +k+g+++ ++g+i vd+fl++ n p+++a GDva   g+
   EFC38576.1 302 LQcDKAGIQTSKDGFIIVDKFLKSvNAPNVWAFGDVA---GN 340
                  **********************7538***********...33 PP

>> Pyr_redox_dim  Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.8   0.0   1.2e-29   3.1e-26       1     109 [.     373     483 ..     373     484 .. 0.93

  Alignments for each domain:
  == domain 1  score: 91.8 bits;  conditional E-value: 1.2e-29
                    BEEEEESSSEEEEEES-HHHHHHHHSGEEEEEEEEECGHHHCHTTHTEEEEEEEEETTTTBEEEEEEECTTHHHHHHHHHHHHHTTS..BHHHHHT CS
  Pyr_redox_dim   1 iptvvftdpevasvGlteeeAkaagieikvgkfpfkangralayaetkgfvKlvadaktgkvlGahivGpgageliqelavaikagl..tvedlad 94 
                    +p +vf++p++a vGlte+e +++g++++ +k +++a++  +a   ++gfvK++++++t+k+lG+hivG++a+ li+++ v+ +     + +dl +
     EFC38576.1 373 MPHAVFSQPQIAGVGLTEQECRKQGLKYVSVKNNYSASAMGMALLSQEGFVKIIVERETRKILGCHIVGHEASTLIHQVIVLFRLPGgpKLDDLLN 468
                    699*****************************************9*************************************99866335568*** PP

                    SBSSSSSTGGGGHCH CS
  Pyr_redox_dim  95 tihihPtlsealkea 109
                    +i ihP lse +++a
     EFC38576.1 469 CIYIHPALSEIVRNA 483
                    *********999876 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.1   1.2         7   1.8e+04       2       8 ..      16      22 ..      16      25 .. 0.87
   2 !   41.4   0.1     6e-14   1.5e-10       2      72 ..     196     266 ..     195     273 .. 0.91

  Alignments for each domain:
  == domain 1  score: -5.1 bits;  conditional E-value: 7
                EEEECSS CS
   Pyr_redox  2 vvvvGgG 8 
                ++v+G+G
  EFC38576.1 16 IIVIGAG 22
                68****9 PP

  == domain 2  score: 41.4 bits;  conditional E-value: 6e-14
                 EEEECSSHHHHHHHHHHHHTTSEEEEEESSSSSSTTSSHHHHHHHHHHHHHT.TEEEECSEEEEEEEEETTS CS
   Pyr_redox   2 vvvvGgGyiglElAgalaelgkkVtvversdkllrllDeeaskilqeklekn.gievllntkveeiegsedg 72 
                 ++v+G+Gyi+ ElA ++a  g k+ +++rs  l   +Dee++k++ + ++k+ +i+v+ + k+ + + ++d+
  EFC38576.1 196 LIVIGAGYIATELAHFFASTGTKTNIFVRSGFLK-HEDEEVQKEFDRVFSKKkNINVIKGMKILKARYENDE 266
                 79***************************97666.**************7777***********99998887 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.7   0.2       4.2   1.1e+04       1       9 [.      17      24 ..      17      44 .. 0.82
   2 !   27.9   0.1     5e-10   1.3e-06     122     305 .]     151     335 ..     138     335 .. 0.82

  Alignments for each domain:
  == domain 1  score: -4.7 bits;  conditional E-value: 4.2
  Pyr_redox_3  1 iIiGaGPaG 9 
                 i+iGaG+ G
   EFC38576.1 17 IVIGAGA-G 24
                 8999996.4 PP

  == domain 2  score: 27.9 bits;  conditional E-value: 5e-10
  Pyr_redox_3 122 tyeAkkviiAtGefdkPnklnipGeeklvkhyskvkefhkyagqkvvViGgknSavDaAlelvrkgaeVtvvtrgseiekeesdpsyslkpdienrle 219
                  +++A++v++A G        +i+G +k++  ++     ++ + + ++ViG++  a + A  ++++g + ++++r+  +++e+++        ++++++
   EFC38576.1 151 VITADRVFVACGARALDLSKEIEGLDKTPYMTYREALRNQKRFKSLIVIGAGYIATELAHFFASTGTKTNIFVRSGFLKHEDEE--------VQKEFD 240
                  799***********************87777766666778899********************************999988744........456777 PP

  Pyr_redox_3 220 elvke.ekikvlfnaevkeikekeeeykvk.....tedgkkvev.kddvvlatGykpdlsflkk..slfeldedgrpvlteeteetnvpglflaG 305
                  ++ ++ ++i+v++  ++ + + ++ e+ ++      e+  ++ev  +  ++a G  p++++l+   +++++++dg++ +++  ++ n p+++  G
   EFC38576.1 241 RVFSKkKNINVIKGMKILKARYENDEFVLTysnpsDESSGTIEVrAEGLLVAAGVVPNTDILQCdkAGIQTSKDGFIIVDKFLKSVNAPNVWAFG 335
                  7776656799999999999999999998883332222223445545566777*********997779***********************99876 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   9.6e-06     0.025       3      54 ..     197     247 ..     195     268 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 9.6e-06
                 EEE--SCCHHHHHHHHHHTT-EEEEE-S-HHHHHHHHHHHHHHHHCCTTTTS CS
     3HCDH_N   3 aviGaGtmGagiaavfasagleVvlvdiseealekalekieksleklvekgk 54 
                  viGaG + +++a+ fas+g +++++ +++ +l++  e+++k+++++ +k+k
  EFC38576.1 197 IVIGAGYIATELAHFFASTGTKTNIF-VRSGFLKHEDEEVQKEFDRVFSKKK 247
                 59*********************998.66789***********999988876 PP

>> Glucokinase  Glucokinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0      0.01        26     127     146 ..      13      32 ..       2      46 .. 0.73
   2 ?   -1.8   0.0      0.49   1.2e+03     229     254 ..     120     145 ..     115     151 .. 0.87
   3 ?    5.3   0.0    0.0031       8.1      86     123 ..     392     429 ..     388     441 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.01
  Glucokinase 127 eapiavlGaGTGLGvallip 146
                  +  i+v+GaG GLG+ +   
   EFC38576.1  13 HYDIIVIGAGAGLGKLGRPA 32 
                  56789*********866555 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.49
  Glucokinase 229 larealelFlailGsvagdlaLklla 254
                   a++ l++F+   G+++g+  +++++
   EFC38576.1 120 EANQKLDWFVGQTGRFVGERTVQVGS 145
                  68899*************99888775 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.0031
  Glucokinase  86 lakelgleaveliNDfeavayaiplleaedlvqlgggk 123
                   +++ gl+ v++ N ++a a++++ll++e +v++  ++
   EFC38576.1 392 ECRKQGLKYVSVKNNYSASAMGMALLSQEGFVKIIVER 429
                  567899***********************999986554 PP

>> GIDA  Glucose inhibited division protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.0    0.0011       2.9       1      59 [.      15      75 ..      15     163 .. 0.88
   2 ?    2.9   0.0     0.018        47       2      29 ..     196     223 ..     195     291 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.0011
                CEEEE-SSHHHHHHHHHHHHTT--EEEE..ES-GGGTT--SSSSEEE-TTHHHHHHHHHHH CS
        GIDA  1 dviViGgGhAGceAAlaaarlGakvlLi..thkldtiaelsCnpsiggiakgllvrEidal 59
                d+iViG+G         a + G++v+L+   +  +t+++ +C ps   i  +++ + i++ 
  EFC38576.1 15 DIIVIGAGAGLGKLGRPATEYGYSVALCenDKLGGTCLNRGCIPSKMLIHPAEVANNIEEA 75
                79******77678899999*********8777789***********999888888777765 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.018
                 EEEE-SSHHHHHHHHHHHHTT--EEEEE CS
        GIDA   2 viViGgGhAGceAAlaaarlGakvlLit 29 
                 +iViG+G   +e A   a  G k+ +++
  EFC38576.1 196 LIVIGAGYIATELAHFFASTGTKTNIFV 223
                 69**********************9983 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       679  (0.0378716); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 3204.48
//
Query:       EFC38577.1  [L=863]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   2.4e-104  347.3   0.2   4.2e-104  346.5   0.2    1.4  1  MCM              MCM P-loop domain
    3.7e-36  123.8   0.4      7e-36  122.9   0.4    1.4  1  MCM_OB           MCM OB domain
    1.2e-24   86.5   0.2      3e-24   85.2   0.2    1.8  1  MCM_lid          MCM AAA-lid domain
    3.2e-11   43.0   0.1    6.3e-09   35.5   0.0    2.9  3  Mg_chelatase     Magnesium chelatase, subunit ChlI
    1.4e-07   31.6   0.0      1e-06   28.8   0.0    2.5  2  AAA_5            AAA domain (dynein-related subfamily)
    5.6e-07   30.1   3.5      1e-06   29.3   0.2    2.9  3  MCM_N            MCM N-terminal domain
    7.9e-06   26.2  24.9    7.9e-06   26.2  24.9    3.6  3  MCM2_N           Mini-chromosome maintenance protein 2
    1.6e-05   24.8   0.1    0.00048   20.0   0.0    2.5  2  AAA_3            ATPase family associated with various cellul
     0.0019   18.6   1.3      0.014   15.8   0.0    3.1  3  AAA              ATPase family associated with various cellul
      0.002   17.9   0.1      0.017   14.9   0.1    2.2  1  Sigma54_activat  Sigma-54 interaction domain
  ------ inclusion threshold ------
      0.031   15.1   0.2      0.031   15.1   0.2    3.0  3  Colicin-DNase    DNase/tRNase domain of colicin-like bacterio
      0.066   13.6   1.0       0.45   10.9   0.1    2.7  3  AAA_16           AAA ATPase domain
       0.13   12.0   2.0       0.17   11.6   0.2    2.1  3  AAA_30           AAA domain
       0.13   12.3   0.0       0.48   10.5   0.0    1.9  1  Sigma54_activ_2  Sigma-54 interaction domain


Domain annotation for each model (and alignments):
>> MCM  MCM P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  346.5   0.2  3.3e-107  4.2e-104       2     224 .]     412     633 ..     411     633 .. 0.98

  Alignments for each domain:
  == domain 1  score: 346.5 bits;  conditional E-value: 3.3e-107
                 HHHHHHHHTSSTHHHHHHHHSSTTSSS-HHHHHHHHHHHH---EBBBSSSSBBCSS-EEEEEESSTSTHHHHHHHHHHHSSSEEEEESSSSSSSHSSSE CS
         MCM   2 veeikelakekdiieklvksiapsiyghedvkkaillqlfggvkkkledktklrgdinvllvgdpgtaKsqlLkyveklapravytsgkgssaagLtaa 100
                 +++i++lak+++i ek++ksiapsi+ghed+kk+i+l+lfggv++ +e+ +++rgdinvll+gdpgtaKsq+Lky+ek+a rav+t+gkgssa+gLta+
  EFC38577.1 412 ERKIQQLAKNPHIQEKIIKSIAPSIFGHEDIKKGIALSLFGGVRRVSEE-HTTRGDINVLLLGDPGTAKSQILKYIEKTATRAVFTTGKGSSAVGLTAS 509
                 789*****************************************87766.999********************************************** PP

                 EEEESSSSSEEEEETHHHHTTTSEEEEESGGGSTCHHHHHHHHHHHHSEEEEESSSCEEEEE--EEEEEEE--SSSSCCTTS-HHHHSSSSHHHHHHSS CS
         MCM 101 vvrdeetgefvleaGalvladkGvcciDefdkmkeedrsalhEamEqqtisiaKaGivatLnartsvlaAanpkagrydkkksvaeninlsaalLsrFD 199
                 v++d+ +ge++le+Galvlad+Gvc+iDefdkm+++dr+++hEamEqq+isi+KaGiv+tL+ar++v+aAanp+ gryd++k++++n++ls+++LsrFD
  EFC38577.1 510 VKKDPINGEWTLEGGALVLADEGVCMIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCAVIAAANPIRGRYDPSKTFHQNVELSEPILSRFD 608
                 *************************************************************************************************** PP

                 EEEEE-SSTTHHHHHHHHHHHHHHH CS
         MCM 200 lifvllDkvdeekDeelaehivslh 224
                 ++f+++D+vde+ De+la+++v++h
  EFC38577.1 609 ILFIVRDTVDEKIDENLAKFVVNSH 633
                 **********************987 PP

>> MCM_OB  MCM OB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  122.9   0.4   5.5e-39     7e-36       1     124 [.     244     372 ..     244     374 .. 0.95

  Alignments for each domain:
  == domain 1  score: 122.9 bits;  conditional E-value: 5.5e-39
                 XXGG--GGGTTSEEEEEEEEEEE---EEEEEEEEEEETTT-.-EE.E......S----SB-..TTT-HHH-EEE-GGGSEEEEEEEEEEE--------- CS
      MCM_OB   1 slRdlrsehigklvkveGivtrasevkpklkkavfeckkcgktve.v......eleePrkCeekeCeskdpfkletekskfvdfqklklQEspeevpaG 92 
                 s+Rdlr++++++l++v+G+vtr++ ++p+lk ++++c kcg++++ +      ++++P++C  + C  k+ f ++  k+ + ++qk+++QE p++vpaG
  EFC38577.1 244 SIRDLRHSSLNQLISVRGVVTRRTAMFPQLKFVKYDCVKCGESLSpIivrnasDVSKPSSC--PGCAGKNCFIINEAKTIYSNYQKITIQEPPGTVPAG 340
                 58****************************************999777887777777****..99********************************** PP

                 ----EEEEEEEGGGTT---TT-EEEEEEEEEE CS
      MCM_OB  93 elPrslevileddlvdkvkPGdrvevtGiyra 124
                 ++Prs++vil ddl+d+ +PG++v vtG+y+ 
  EFC38577.1 341 RIPRSKDVILVDDLIDCTRPGEEVIVTGVYKQ 372
                 ******************************86 PP

>> MCM_lid  MCM AAA-lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.2   0.2   2.4e-27     3e-24       2      87 .]     679     761 ..     678     761 .. 0.95

  Alignments for each domain:
  == domain 1  score: 85.2 bits;  conditional E-value: 2.4e-27
                 HHHHHHHHHHHTT--BETCHHHHHHHHHHHHHHHHHTSSTSSSST--HHHHHHHHHHHHHHHHHHTSSSE-HHHHHHHHHHHHHHH CS
     MCM_lid   2 llrkYiayarekikPklseeakeklseaYvelRkeeedskrksipitvRqLesliRLseAlAklrlsevvteedveeairllkesl 87 
                 +++kY+ +a+ +i+P ls   ke l+++Y elRk++e  + + ++it+R+Les+iR+seA+Ak++l+++v+++dv+ ai+++ es+
  EFC38577.1 679 MFKKYLMMAK-RIRPNLSGINKERLTKFYSELRKHSE--EGSGLTITARHLESIIRMSEASAKMHLRSTVNDSDVNTAISVMLESF 761
                 79********.***********************995..4799***************************************9986 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.021        27      20      43 ..     464     487 ..     455     499 .. 0.86
   2 !   35.5   0.0   4.9e-12   6.3e-09      93     202 ..     517     616 ..     503     621 .. 0.85
   3 ?   -2.6   0.0       2.3   2.9e+03      31      54 ..     715     738 ..     713     754 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.021
  Mg_chelatase  20 aGgHnlllvGppGsGKtmlakrlp 43 
                    G  n+ll+G pG+ K+ + k ++
    EFC38577.1 464 RGDINVLLLGDPGTAKSQILKYIE 487
                   6889*************9988775 PP

  == domain 2  score: 35.5 bits;  conditional E-value: 4.9e-12
  Mg_chelatase  93 ggskpkpGeislahnGvLfLDElpefkrkvlevLRePledgevtisrakakvefparfqlvaamNpcpcgklkdkekectcsekeierYlsklsgpl 189
                   g  + + G++ la +Gv ++DE+ +++ +   ++ e +e+++++is+a   ++  ar+ ++aa+Np +  +++ ++        ++ +    ls+p+
    EFC38577.1 517 GEWTLEGGALVLADEGVCMIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCAVIAAANPIRG-RYD-PS--------KTFHQNVELSEPI 603
                   6667889***********************************************************985.444.32........23333457999** PP

  Mg_chelatase 190 ldRidlqvevkkl 202
                   l R+d+ + v+ +
    EFC38577.1 604 LSRFDILFIVRDT 616
                   ****999888655 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 2.3
  Mg_chelatase  31 pGsGKtmlakrlpsllpplseeea 54 
                    GsG t+ a+ l+s++   + +  
    EFC38577.1 715 EGSGLTITARHLESIIRMSEASAK 738
                   599**********99866555444 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       1.7   2.1e+03      99     136 ..      63      90 ..      42      90 .. 0.65
   2 !   28.8   0.0   8.1e-10     1e-06       1     138 []     468     607 ..     468     607 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.7
                 SSSEEE---......-EEEEEESS--..-TT-TTHHHHT CS
       AAA_5  99 ggelvkaknddllerfrviatanpld.rslnelspalrs 136
                  + +           ++v  ++n++d  ++ e+++a+r+
  EFC38577.1  63 YHDR-----------LNVENLMNSRDeEEEDEIDQAIRR 90 
                 3333...........344447888888888888888875 PP

  == domain 2  score: 28.8 bits;  conditional E-value: 8.1e-10
                 EEEEE--SSSSHHHHHHHGGGGB.......S--EEEEE--TT--HHHHH--B--.........--------G-SEEEEESGGG--HHHHHHHHHHHHSS CS
       AAA_5   1 dvlLvGppGtgKselaerlaaal.......nreveyvqltrdtteedlkgrreikngttslvdsplvraaregeilvlDEveraesevlnsLlslleer 92 
                 +vlL+G+pGt+Ks++ +++ +         ++    v lt++ +++ + g++        l+ ++lv       ++++DE+++++++   s +  +e++
  EFC38577.1 468 NVLLLGDPGTAKSQILKYIEKTAtravfttGKGSSAVGLTASVKKDPINGEWT-------LEGGALV--LADEGVCMIDEFDKMNDQDRTSIHEAMEQQ 557
                 69*****************9988555555566666677777777777777777.......5899999..66778************************* PP

                 EEE..-SSSEEE---......-EEEEEESS--..........-TT-TTHHHHTT- CS
       AAA_5  93 rllleeggelvkaknddllerfrviatanpld.........rslnelspalrsRf 138
                  +++ + g ++  ++        via+anp +         ++  els++++sRf
  EFC38577.1 558 SISISKAGIVTTLQAR-----CAVIAAANPIRgrydpsktfHQNVELSEPILSRF 607
                 ***9999988888775.....9********9977666666666666666666666 PP

>> MCM_N  MCM N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.2   7.9e-10     1e-06       4     104 .]     157     238 ..     154     255 .. 0.89
   2 ?   -3.0   0.0       8.7   1.1e+04      22      47 ..     703     727 ..     677     729 .. 0.59
   3 ?   -0.5   0.1       1.5   1.9e+03      65      94 ..     788     812 ..     774     829 .. 0.46

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 7.9e-10
       MCM_N   4 FedFLeefkddsededgekkYrdqlqemaerekttLevdlddLaafdeeLaeailenpkeylplleealkevvkklepsykddakefpaeltrrfqvrf 102
                 F++F+ e         ++ +Y++ +++   ++k+++ v+++dL ++ ++L   +++ p   ++l+eea++++v+  +p+y  d          +f++r+
  EFC38577.1 157 FRRFFTEE--------KREVYMEAIKHAVANNKKSIVVNFTDL-SVAPHLLLLLTDLPDATIELMEEAVNRIVELQYPNYVGD----------DFHIRI 236
                 67777766........79*************************.78899************************9999999877..........666665 PP

       MCM_N 103 kn 104
                 kn
  EFC38577.1 237 KN 238
                 54 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 8.7
       MCM_N  22 kkYrdqlqemaerekttLevdlddLa 47 
                 +k+ ++l++   +e + L++  ++L+
  EFC38577.1 703 TKFYSELRK-HSEEGSGLTITARHLE 727
                 566666777.4556678888888887 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 1.5
       MCM_N  65 lplleealkevvkklepsykddakefpael 94 
                 ++ll   l+e+vk+   s +d+     +e+
  EFC38577.1 788 HQLLLHILNEMVKTKISSMADE-----DEE 812
                 3344444444444433333333.....333 PP

>> MCM2_N  Mini-chromosome maintenance protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2  24.9   6.2e-09   7.9e-06      14     111 ..      12     113 ..       3     149 .. 0.68
   2 ?   -2.3   0.1       3.7   4.8e+03      57      76 ..     538     557 ..     536     565 .. 0.78
   3 ?    1.5   0.1      0.26   3.4e+02      87     148 ..     774     835 ..     764     837 .. 0.61

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 6.2e-09
      MCM2_N  14 dldev.aaeeeedgeDLfndn.ledDyrene.eqDrYdlddidDendldeldaaeRraieaeLdrRDrelk...araarrsk.laafLqdddded.eld 104
                 +++e+  +eeee+geDLf+d+ le+Dy + + e+D Yd  +  D++ +  ++  +R ++e+ ++ RD+e++   ++a rrs    + L + dd   +l 
  EFC38577.1  12 YEEEIpFDEEEEEGEDLFADDvLEEDYTKGPtEEDFYDE-QYIDNTTYHPMSYHDRLNVENLMNSRDEEEEdeiDQAIRRSEnKRKSLPSSDDAIlHLL 109
                 333444568**********99789***998637788885.5556679**********************998874444444446678888887544322 PP

      MCM2_N 105 delglpi 111
                 ++   + 
  EFC38577.1 110 GD---DN 113
                 22...22 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 3.7
      MCM2_N  57 dldeldaaeRraieaeLdrR 76 
                 ++d+++ ++R  i ++++++
  EFC38577.1 538 EFDKMNDQDRTSIHEAMEQQ 557
                 68899999999999888875 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.26
      MCM2_N  87 rsklaafLqddddedelddelglpiqkrRrRreydedededldead..ideleeelsleslaDv 148
                 ++k +++Lq+  d+ +l  ++  ++ k +   + ++dede+ +e    i+e+++e+  + ++D+
  EFC38577.1 774 KRKFKRYLQSPTDDHQLLLHILNEMVKTKIS-S-MADEDEEEEELSisIKEFKNEVAKNRIFDI 835
                 5678889999887665444444433332222.2.345555555543348899999988888887 PP

>> AAA_3  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.16     2e+02      40      92 ..     363     416 ..     350     432 .. 0.76
   2 !   20.0   0.0   3.7e-07   0.00048       2     114 ..     469     584 ..     468     593 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.16
       AAA_3  40 dilGtevfeekekef.efkkG.pvfanllladeinrappktqsalleameerqvt 92 
                 +++ t v++++   f ++k+G pvfa ++ a+ +++   k   a+ +  +er++ 
  EFC38577.1 363 EVIVTGVYKQNYDAFlNVKQGfPVFATIIEANYVEKIFDKRSEAITK-EDERKIQ 416
                 5777889999886653788988**********999998887777654.4555555 PP

  == domain 2  score: 20.0 bits;  conditional E-value: 3.7e-07
       AAA_3   2 vllegvPGlaktllvkalakaldlefkriqftpdllPsdilGtevfeeke..kefefkkGpvf.an..llladeinrappktqsalleameerqvtveg 95 
                 vll g PG+ak ++ k     ++ + +r  ft+    s +  t  ++++    e++++ G+++ a+  + + de ++ + + ++++ eame++ +++++
  EFC38577.1 469 VLLLGDPGTAKSQILKY----IEKTATRAVFTTGKGSSAVGLTASVKKDPinGEWTLEGGALVlADegVCMIDEFDKMNDQDRTSIHEAMEQQSISISK 563
                 799999*****988876....566678999999876666544444444335599******976332449************************999876 PP

       AAA_3  96 e..thklpepflvlatqnPie 114
                 +   ++l+    v+a+ nPi 
  EFC38577.1 564 AgiVTTLQARCAVIAAANPIR 584
                 522689*************95 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       7.1   9.1e+03      65      74 ..      82      91 ..      79     109 .. 0.66
   2 !   15.8   0.0   1.1e-05     0.014       1     111 [.     469     582 ..     469     611 .. 0.78
   3 ?   -0.8   0.0       1.5   1.9e+03      52      97 ..     708     765 ..     683     784 .. 0.66

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 7.1
                ETGGGHHHHH CS
         AAA 65 DEidalaksr 74
                DEid+ ++++
  EFC38577.1 82 DEIDQAIRRS 91
                6777776666 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 1.1e-05
                 EEEESSTTSSHHHHHHHHHHHHT.HEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTS....TSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHH CS
         AAA   1 vllyGppGtGKTllakavakelg.vefleisgsellskyvgesekkirelfkeakeka....kpsilfiDEidalaksrsgseseeeervvnqLlteld 94 
                 vll G pGt K+ + k + k++  + f + +gs+ +  + + +++ i++ ++  +  a    +  + +iDE+d+++ ++ +++  e+++ ++  +++  
  EFC38577.1 469 VLLLGDPGTAKSQILKYIEKTATrAVFTTGKGSSAVGLTASVKKDPINGEWTL-EGGAlvlaDEGVCMIDEFDKMNDQD-RTSIHEAMEQQSISISKAG 565
                 79*******************97244677799999988888888888887765.4455678666***********8888.4555555555555556666 PP

                 HTTTSSSTEEEEEEESS CS
         AAA  95 gvkkkeskvivigatnr 111
                  v++ ++++ vi+a+n 
  EFC38577.1 566 IVTTLQARCAVIAAANP 582
                 66666999999999996 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 1.5
                 HHHHTS...........TS.EEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTT CS
         AAA  52 eakeka...........kp.silfiDEidalaksrsgseseeeervvnqLlteldgvk 97 
                 e+++++           +  si+ + E+ a +  rs+ ++++ +++++++l+ +   +
  EFC38577.1 708 ELRKHSeegsgltitarHLeSIIRMSEASAKMHLRSTVNDSDVNTAISVMLESFISTQ 765
                 3333333333333444322389999999998888888888888888888887665555 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1   1.3e-05     0.017      18     142 ..     462     581 ..     453     597 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.3e-05
                      HCTSSS-EEEECSTTSSHHHHHHHHHHHSTTTTS-EEEEETTTS-TTCHHHHHHEBSSSSSTTTSS-BEHHHHHTTTSEEEEETGGGS-HHHHH CS
  Sigma54_activat  18 vaktdlsvlitGesGtGKellaraiheaskrkekpfvavncaaipeelleseLFGhekGaFtGAekekkGlfekadgGtlfLDeigelplelQe 111
                      +++ d++vl++G+ Gt K+ + + i ++ +r    + +   ++ +  l +s    ++k    G  + + G++  ad+G+ ++De  +++ +  +
       EFC38577.1 462 TTRGDINVLLLGDPGTAKSQILKYIEKTATR---AVFTTGKGSSAVGLTAS----VKKDPINGEWTLEGGALVLADEGVCMIDEFDKMNDQDRT 548
                      4566799***********9999999876664...45566777888888888....79999999999999************************* PP

                      HHHHHHHHSE..EESBTSSSEEE--EEEEEEES CS
  Sigma54_activat 112 kLlrvlqege..vervGsskeikvdvriiaatn 142
                       + +++++++  +++ G  ++ ++ + +iaa+n
       EFC38577.1 549 SIHEAMEQQSisISKAGIVTTLQARCAVIAAAN 581
                      ******9997225799***************98 PP

>> Colicin-DNase  DNase/tRNase domain of colicin-like bacteriocin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.2   2.4e-05     0.031       5      55 ..     381     430 ..     378     444 .. 0.85
   2 ?   -2.1   0.3       5.8   7.4e+03      39      55 ..     642     658 ..     615     683 .. 0.47
   3 ?   -2.3   0.2       6.3   8.1e+03      27      52 ..     811     836 ..     795     853 .. 0.57

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.4e-05
  Colicin-DNase   5 keGfPvFdsaakvkleeellkksrevqfksankklkeelakdpklankftk 55 
                    k+GfPvF  +++++   e+++++r+  +++ +++ +++lak+p  ++k+ k
     EFC38577.1 381 KQGFPVFATIIEANY-VEKIFDKRSEAITKEDERKIQQLAKNPHIQEKIIK 430
                    79*********9976.6667778999999999************9999544 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 5.8
  Colicin-DNase  39 lkeelakdpklankftk 55 
                    l++++++ ++ ++++ +
     EFC38577.1 642 LLRKVQEQEAARRELLE 658
                    22333333333333222 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 6.3
  Colicin-DNase  27 srevqfksankklkeelakdpklank 52 
                     +e + +   k++k+e+ak++  +  
     EFC38577.1 811 EEEEELSISIKEFKNEVAKNRIFDIS 836
                    55566666667777777777666555 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       9.7   1.2e+04      71     105 ..     386     419 ..     366     435 .. 0.63
   2 ?   10.9   0.1   0.00035      0.45      25      63 ..     467     503 ..     454     555 .. 0.85
   3 ?   -1.1   0.0       1.6   2.1e+03      82     154 ..     643     739 ..     591     756 .. 0.57

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 9.7
      AAA_16  71 alaqalareellrqlldeaesaeleawrekleeal 105
                 ++a+++++  +++++ d+ ++a   ++ +k+++ +
  EFC38577.1 386 VFATIIEA-NYVEKIFDKRSEAITKEDERKIQQLA 419
                 27777755.88888888866655555555555544 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00035
      AAA_16  25 elvllsGesGvGKsslvrellralekdggiflrgkcdql 63 
                  +vll G++G+ Ks +++ + + ++++  +f++gk  + 
  EFC38577.1 467 INVLLLGDPGTAKSQILKYIEKTATRA--VFTTGKGSSA 503
                 489******************988876..8888887665 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 1.6
      AAA_16  82 lrqlldeaesaeleawrekleeala...........................avpelagaeasrllellkrllallsrderplvlvlDdlq...wadea 150
                 lr++ ++ e+a +e   ek     +                           + p+l+g  ++rl    ++l + +++ ++ l ++  +l+   +  ea
  EFC38577.1 643 LRKVQEQ-EAARRELLEEKN----EateedflfnkegipqdmfkkylmmakrIRPNLSGINKERLTKFYSELRKHSEE-GSGLTITARHLEsiiRMSEA 735
                 2222222.111111111111....122234444444455677778888777777777777777777666666655555.33366665555555555555 PP

      AAA_16 151 slql 154
                 s+++
  EFC38577.1 736 SAKM 739
                 5555 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       4.1   5.3e+03      34      59 ..     153     178 ..     135     183 .. 0.54
   2 ?   11.6   0.2   0.00013      0.17      11     119 ..     459     561 ..     454     566 .. 0.80
   3 ?   -3.8   0.0       6.8   8.7e+03     147     176 ..     722     752 ..     720     757 .. 0.66

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.1
      AAA_30  34 alkalreaweaaggrviglAptgkaA 59 
                 +lk+ r+ +++++++v + A ++++A
  EFC38577.1 153 ILKGFRRFFTEEKREVYMEAIKHAVA 178
                 34445555555555555555544444 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00013
      AAA_30  11 ealltsgdrvavltGpAGtGKttalkalreaweaaggrviglAptgkaAkvLaeelgieastiakllkrlkgrarlepgtllivDEagmvdtkqlaall 109
                 e+ +t gd  ++l G +Gt K+ +lk +++++++a    +  + +g  A  L++   ++ + i+  ++  +g+  l+++ + ++DE   ++ ++ +++ 
  EFC38577.1 459 EEHTTRGDINVLLLGDPGTAKSQILKYIEKTATRA----VFTTGKGSSAVGLTA--SVKKDPINGEWTLEGGALVLADEGVCMIDEFDKMNDQDRTSIH 551
                 667888898999****************9999966....456666666666775..57788888888667777888899999****9999999999999 PP

      AAA_30 110 kaaekagakv 119
                 +a+e++++++
  EFC38577.1 552 EAMEQQSISI 561
                 9999877665 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 6.8
      AAA_30 147 gtaeLtevvRqke.seeraaalalregdaee 176
                 ++ +L++++R++e s+  ++   +++ d+++
  EFC38577.1 722 TARHLESIIRMSEaSAKMHLRSTVNDSDVNT 752
                 5678999999987566666666666666555 PP

>> Sigma54_activ_2  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00038      0.48      19      97 ..     464     558 ..     459     583 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00038
                      T-SS-EEEEEETT--HHHHHHCC--TTS-EE--SSTTHHHH-H.............HHHHHH.........TTTSEEEEEE-TT--HHHHHHHH CS
  Sigma54_activ_2  19 qsklpvfltGekGsgkelvArlLhknsgpwleifvverlaklp.............ldlleq.........akggtLylkdiadlskaeqkeLl 90 
                      +   +v+l+G++G+ k+ + +++ k +++  ++f+  +++++                             a++g+ ++ ++++++ ++ + + 
       EFC38577.1 464 RGDINVLLLGDPGTAKSQILKYIEKTATR--AVFTTGKGSSAVgltasvkkdpingE----WtleggalvlADEGVCMIDEFDKMNDQDRTSIH 551
                      66789************************..77777777764444455555555542....03334766668*******************999 PP

                      HHHHHHT CS
  Sigma54_activ_2  91 ellakae 97 
                      e+++++ 
       EFC38577.1 552 EAMEQQS 558
                      9999864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (863 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1084  (0.0604607); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.80u 0.29s 00:00:01.09 Elapsed: 00:00:00.47
# Mc/sec: 5500.86
//
Query:       EFC38578.1  [L=663]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-55  184.3  18.2      6e-09   36.3   0.0   11.4 11  Sel1      Sel1 repeat
    5.9e-09   35.3   4.2       0.43   10.7   0.0    6.7  7  TPR_7     Tetratricopeptide repeat
    1.7e-07   30.9  13.9     0.0037   17.1   0.8    6.1  6  TPR_10    Tetratricopeptide repeat
    1.1e-05   25.6  11.2     0.0022   18.3   1.3    5.2  4  TPR_12    Tetratricopeptide repeat
      2e-05   24.2  28.4    0.00065   19.4   1.0    8.4 10  TPR_1     Tetratricopeptide repeat
    4.6e-05   23.2  23.2     0.0073   16.3   0.9    8.4 10  TPR_2     Tetratricopeptide repeat
     0.0026   18.3   7.9         22    5.9   0.3    6.3  6  TPR_6     Tetratricopeptide repeat
     0.0028   17.8   1.9       0.22   11.8   0.5    3.0  2  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
     0.0047   17.0  18.0        1.6    9.1   0.4    7.4  6  TPR_8     Tetratricopeptide repeat
     0.0076   15.8   0.7      0.021   14.3   0.1    2.0  2  DUF5112   Domain of unknown function (DUF5112)
  ------ inclusion threshold ------
      0.024   15.0  17.9         18    6.0   3.8    7.3  7  TPR_17    Tetratricopeptide repeat
      0.087   12.8   0.6        1.7    8.7   0.6    3.1  2  TPR_3     Tetratricopeptide repeat
       0.38   11.4   0.1       0.38   11.4   0.1    4.4  6  TPR_16    Tetratricopeptide repeat
        5.2    7.7   7.4          2    9.0   0.2    3.7  4  TPR_19    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   0.1    0.0011       1.4      13      37 ..     269     293 ..     261     294 .. 0.87
   2 !   18.3   0.0   2.1e-06    0.0027       1      38 []     295     330 ..     295     330 .. 0.93
   3 !   13.5   0.0     7e-05     0.089       1      36 [.     331     364 ..     331     366 .. 0.88
   4 !   20.3   0.1   5.2e-07   0.00066       3      37 ..     369     401 ..     367     402 .. 0.90
   5 !   28.5   0.0   1.3e-09   1.7e-06       1      38 []     403     438 ..     403     438 .. 0.94
   6 !   21.4   0.1   2.4e-07    0.0003       2      38 .]     440     474 ..     439     474 .. 0.95
   7 !    8.6   0.1    0.0025       3.2       4      38 .]     478     506 ..     476     506 .. 0.75
   8 !   18.8   0.0   1.5e-06     0.002       2      38 .]     508     542 ..     507     542 .. 0.95
   9 !    8.6   0.1    0.0025       3.2       3      38 .]     545     580 ..     543     580 .. 0.80
  10 !   36.3   0.0   4.7e-12     6e-09       1      38 []     581     617 ..     581     617 .. 0.93
  11 ?    2.2   0.0      0.25   3.2e+02       4      38 .]     621     649 ..     619     649 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0011
        Sel1  13 ylnGlgvpkDpekAiewyekAAeqG 37 
                 ++ G gv ++ e A+++y  AA++G
  EFC38578.1 269 FYIGHGVTQNFEMAFRLYLHAARLG 293
                 45799******************99 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 2.1e-06
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a ++y +G+++   +G gv+kD +++++w  k+A+q++
  EFC38578.1 295 ARSQYVVGTML--IEGVGVEKDTRQGVKWTLKSAAQDY 330
                 579*****888..***********************85 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 7e-05
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeq 36 
                 +++++++G fy  ++G  v+ +p  A ++y +A  +
  EFC38578.1 331 PDSLNQMGIFY--EKGFVVEENPTFAAKFYLRATHM 364
                 57899***777..****9***************766 PP

  == domain 4  score: 20.3 bits;  conditional E-value: 5.2e-07
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                  m +++   l+l+G gv+k+++kA  +++kA+e++
  EFC38578.1 369 GMTNYA--SLLLHGNGVEKNEQKAAWLLRKACERN 401
                 68999*..777*********************987 PP

  == domain 5  score: 28.5 bits;  conditional E-value: 1.3e-09
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a A++ LG   ++++Glg++ +p+kA+e++ ++A++G+
  EFC38578.1 403 AKAQNELG--VMFYKGLGIEENPDKAVELFTLSADRGN 438
                 68******..7778**********************97 PP

  == domain 6  score: 21.4 bits;  conditional E-value: 2.4e-07
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +A+++LG   +y++G+gv +D+ kA  +yek+ ++G+
  EFC38578.1 440 YALNNLG--IAYEEGKGVVRDYAKATLCYEKSSKLGN 474
                 799****..888***********************97 PP

  == domain 7  score: 8.6 bits;  conditional E-value: 0.0025
        Sel1   4 myrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +++LG  y   + l   k +++A+e++++AA++G+
  EFC38578.1 478 LNNLG--Y--IKLL--QKQYDEALELLHQAADRGS 506
                 56666..5..4443..5669*************96 PP

  == domain 8  score: 18.8 bits;  conditional E-value: 1.5e-06
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +Amy+ G +y    Glgv + p++ ++++ +AA++G+
  EFC38578.1 508 DAMYNIGNVY--RIGLGVNAEPSLSLKFLYRAANLGH 542
                 7******777..************************9 PP

  == domain 9  score: 8.6 bits;  conditional E-value: 0.0025
        Sel1   3 AmyrLGmfylylnGlg..vpkDpekAiewyekAAeqGd 38 
                 A+  +G   +++ G g  +p ++++A  +y kAA +Gd
  EFC38578.1 545 AQKLVG--DILYSGVGeaIPSNRKEAASFYYKAALNGD 580
                 666788..4457777665888*************9997 PP

  == domain 10  score: 36.3 bits;  conditional E-value: 4.7e-12
        Sel1   1 aeAmyrLGmfylylnGl.gvpkDpekAiewyekAAeqGd 38 
                 a+A+++LG   +y++G  gv+kD+ekA+ w++kA ++G+
  EFC38578.1 581 ADACNNLG--IMYEDGSsGVEKDEEKAVLWFRKASNLGS 617
                 68******..777****99******************96 PP

  == domain 11  score: 2.2 bits;  conditional E-value: 0.25
        Sel1   4 myrLGmfylylnGlgvpkD.pekAiewyekAAeqGd 38 
                 m++L+ +y  + +     + +e+A  +++kA ++G+
  EFC38578.1 621 MFNLAAIY--ERR-----NkKEEATTLLRKASMLGN 649
                 66777333..555.....437889999999999997 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       1.5   1.9e+03       1      29 [.     333     363 ..     333     370 .. 0.80
   2 ?   -0.6   0.0       1.4   1.8e+03      14      24 ..     422     432 ..     408     436 .. 0.84
   3 !   10.7   0.0   0.00034      0.43       1      25 [.     441     469 ..     441     474 .. 0.94
   4 !    8.7   0.3    0.0015       1.9       1      28 [.     477     502 ..     477     518 .. 0.91
   5 ?   -2.6   0.0       6.2     8e+03      14      22 ..     564     572 ..     563     579 .. 0.76
   6 ?    0.1   0.0      0.82     1e+03       1      11 [.     583     593 ..     583     612 .. 0.87
   7 !    8.7   0.0    0.0015       1.9       3      27 ..     622     644 ..     621     651 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.5
       TPR_7   1 aLlnLarlysr....lGdyeeAielyeqsLalt 29 
                 +L++++  y++    + +   A+++y +  a++
  EFC38578.1 333 SLNQMGIFYEKgfvvEENPTFAAKFYLR--ATH 363
                 6888888888888888888889999999..766 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.4
       TPR_7  14 dyeeAielyeq 24 
                 + ++A+el++ 
  EFC38578.1 422 NPDKAVELFTL 432
                 779*****986 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00034
       TPR_7   1 aLlnLarlysr....lGdyeeAielyeqs 25 
                 aL+nL+ +y++    ++dy++A  +ye+s
  EFC38578.1 441 ALNNLGIAYEEgkgvVRDYAKATLCYEKS 469
                 89*************************95 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.0015
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLal 28 
                 aL+nL+ +   + +y+eA+el+ q  a 
  EFC38578.1 477 ALNNLGYIKLLQKQYDEALELLHQ--AA 502
                 89*********************9..55 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 6.2
       TPR_7  14 dyeeAiely 22 
                 +++eA+++y
  EFC38578.1 564 NRKEAASFY 572
                 678999988 PP

  == domain 6  score: 0.1 bits;  conditional E-value: 0.82
       TPR_7   1 aLlnLarlysr 11 
                 a++nL+ +y++
  EFC38578.1 583 ACNNLGIMYED 593
                 79******987 PP

  == domain 7  score: 8.7 bits;  conditional E-value: 0.0015
       TPR_7   3 lnLarlysrlGdyeeAielyeqsLa 27 
                 +nLa +y+r+++ eeA +l+++  a
  EFC38578.1 622 FNLAAIYERRNKKEEATTLLRK--A 644
                 69*****************999..4 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       6.9   8.9e+03       2      11 ..     403     412 ..     403     414 .. 0.82
   2 ?    3.9   0.0     0.041        53       4      12 ..     441     449 ..     439     453 .. 0.89
   3 !   17.1   0.8   2.9e-06    0.0037       3      30 ..     476     503 ..     475     505 .. 0.93
   4 ?   -0.7   0.0       1.1   1.4e+03       3      13 ..     508     518 ..     507     519 .. 0.88
   5 ?    3.8   0.0     0.043        55       2      12 ..     581     591 ..     581     593 .. 0.90
   6 !    9.8   0.3   0.00058      0.74       7      28 ..     623     644 ..     623     644 .. 0.98

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 6.9
      TPR_10   2 AsslnNLana 11 
                 A ++n L+++
  EFC38578.1 403 AKAQNELGVM 412
                 6799****87 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.041
      TPR_10   4 slnNLanal 12 
                 +lnNL++a+
  EFC38578.1 441 ALNNLGIAY 449
                 8*******9 PP

  == domain 3  score: 17.1 bits;  conditional E-value: 2.9e-06
      TPR_10   3 sslnNLanalrqrgrydeAealleeala 30 
                 ++lnNL+ +   +++ydeA++ll++a +
  EFC38578.1 476 NALNNLGYIKLLQKQYDEALELLHQAAD 503
                 79***********************975 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 1.1
      TPR_10   3 sslnNLanalr 13 
                  ++ N++n++r
  EFC38578.1 508 DAMYNIGNVYR 518
                 5899******7 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.043
      TPR_10   2 AsslnNLanal 12 
                 A ++nNL++++
  EFC38578.1 581 ADACNNLGIMY 591
                 789*******9 PP

  == domain 6  score: 9.8 bits;  conditional E-value: 0.00058
      TPR_10   7 NLanalrqrgrydeAealleea 28 
                 NLa+++ +r++ +eA  ll++a
  EFC38578.1 623 NLAAIYERRNKKEEATTLLRKA 644
                 9*******************98 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       2.7   3.4e+03      17      33 ..     277     293 ..     276     299 .. 0.70
   2 ?    1.7   0.1      0.26   3.3e+02      28      57 ..     425     451 ..     419     472 .. 0.72
   3 !   18.3   1.3   1.7e-06    0.0022       4      32 ..     476     504 ..     473     520 .. 0.85
   4 !    7.9   0.0    0.0028       3.6      48      71 ..     621     644 ..     600     647 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2.7
      TPR_12  17 grydeAlellekaleia 33 
                 ++++ A++l+ +a ++ 
  EFC38578.1 277 QNFEMAFRLYLHAARLG 293
                 57788888888887664 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.26
      TPR_12  28 kaleiarrllGpdhpltattlrnLgrlyra 57 
                 ka+e+++  l  d+ + + +l+nLg++y++
  EFC38578.1 425 KAVELFT--LSADR-GNVYALNNLGIAYEE 451
                 6677774..33666.677899999999964 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 1.7e-06
      TPR_12   4 talnnlaavlrrlgrydeAlellekalei 32 
                 +alnnl+ + + +++ydeAlell++a ++
  EFC38578.1 476 NALNNLGYIKLLQKQYDEALELLHQAADR 504
                 7899**********************664 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0028
      TPR_12  48 lrnLgrlyralgryeeAlelleea 71 
                 ++nL+ +y+++++ eeA  ll++a
  EFC38578.1 621 MFNLAAIYERRNKKEEATTLLRKA 644
                 89*******************998 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       2.4   3.1e+03       1      13 [.     403     415 ..     403     415 .. 0.91
   2 ?   -2.2   0.0       3.4   4.4e+03      15      24 ..     421     430 ..     419     431 .. 0.81
   3 ?    4.0   0.1     0.039        50       2      12 ..     440     450 ..     439     453 .. 0.88
   4 ?    1.1   0.1      0.31     4e+02      16      27 ..     458     469 ..     456     472 .. 0.86
   5 !   19.4   1.0   5.1e-07   0.00065       2      27 ..     476     501 ..     475     504 .. 0.93
   6 ?    3.1   0.0     0.072        92       2      12 ..     508     518 ..     507     519 .. 0.88
   7 ?   -2.5   0.5       4.4   5.6e+03      17      28 ..     566     577 ..     564     577 .. 0.65
   8 ?    3.2   0.0     0.065        84       1      12 [.     581     592 ..     581     593 .. 0.91
   9 ?   -3.4   0.0       8.1     1e+04      18      27 ..     603     612 ..     600     612 .. 0.80
  10 !    7.4   0.1    0.0032       4.1       5      27 ..     622     644 ..     619     645 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.4
                 HHHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayfk 13 
                 aka + lG++++k
  EFC38578.1 403 AKAQNELGVMFYK 415
                 7999*****9997 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 3.4
                 T-HHHHHHHH CS
       TPR_1  15 gkydeAleyy 24 
                 +++d+A+e +
  EFC38578.1 421 ENPDKAVELF 430
                 6899999987 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.039
                 HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayf 12 
                 +al+nlG ay 
  EFC38578.1 440 YALNNLGIAYE 450
                 79********7 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.31
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 +y +A  +yek 
  EFC38578.1 458 DYAKATLCYEKS 469
                 8*********96 PP

  == domain 5  score: 19.4 bits;  conditional E-value: 5.1e-07
                 HHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekA 27 
                 +al+nlG++ + +++ydeAle   +A
  EFC38578.1 476 NALNNLGYIKLLQKQYDEALELLHQA 501
                 69*******************99998 PP

  == domain 6  score: 3.1 bits;  conditional E-value: 0.072
                 HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayf 12 
                 +a yn+Gn+y+
  EFC38578.1 508 DAMYNIGNVYR 518
                 799*******6 PP

  == domain 7  score: -2.5 bits;  conditional E-value: 4.4
                 HHHHHHHHHHHH CS
       TPR_1  17 ydeAleyyekAL 28 
                  + A  yy+ AL
  EFC38578.1 566 KEAASFYYKAAL 577
                 566777777776 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.065
                 HHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayf 12 
                 a+a++nlG +y 
  EFC38578.1 581 ADACNNLGIMYE 592
                 89********96 PP

  == domain 9  score: -3.4 bits;  conditional E-value: 8.1
                 HHHHHHHHHH CS
       TPR_1  18 deAleyyekA 27 
                 ++A+  ++kA
  EFC38578.1 603 EKAVLWFRKA 612
                 8999999998 PP

  == domain 10  score: 7.4 bits;  conditional E-value: 0.0032
                 HHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyyekA 27 
                 +nl+++y + +k +eA    +kA
  EFC38578.1 622 FNLAAIYERRNKKEEATTLLRKA 644
                 8***************9988887 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       2.1   2.7e+03      15      30 ..     277     292 ..     275     295 .. 0.87
   2 ?   -2.4   0.0       5.6   7.2e+03      16      25 ..     422     431 ..     420     433 .. 0.82
   3 ?    0.8   0.1      0.54   6.9e+02       2      12 ..     440     450 ..     439     453 .. 0.86
   4 ?    1.9   0.0      0.24     3e+02      16      29 ..     458     471 ..     455     473 .. 0.86
   5 !   16.3   0.9   5.7e-06    0.0073       3      28 ..     477     502 ..     475     504 .. 0.93
   6 ?   -0.7   0.0       1.7   2.1e+03       2      12 ..     508     518 ..     507     519 .. 0.87
   7 ?   -1.2   0.3       2.3     3e+03      15      28 ..     564     577 ..     563     578 .. 0.84
   8 ?   -0.8   0.0       1.8   2.3e+03       1      12 [.     581     592 ..     581     593 .. 0.88
   9 ?   -0.5   0.0       1.4   1.7e+03      16      30 ..     601     615 ..     599     619 .. 0.79
  10 !   11.0   0.1   0.00029      0.37       4      27 ..     621     644 ..     618     647 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 2.1
       TPR_2  15 gdyeeAleafekAlel 30 
                 +++e A +++  A +l
  EFC38578.1 277 QNFEMAFRLYLHAARL 292
                 79999*****999987 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 5.6
       TPR_2  16 dyeeAleafe 25 
                 ++++A+e+f 
  EFC38578.1 422 NPDKAVELFT 431
                 8899999985 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.54
       TPR_2   2 ealynlGlayy 12 
                 +al+nlG ay+
  EFC38578.1 440 YALNNLGIAYE 450
                 79********7 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.24
       TPR_2  16 dyeeAleafekAle 29 
                 dy++A  ++ek+ +
  EFC38578.1 458 DYAKATLCYEKSSK 471
                 9*********9866 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 5.7e-06
       TPR_2   3 alynlGlayyklgdyeeAleafekAl 28 
                 al+nlG++ + +++y+eAle++ +A 
  EFC38578.1 477 ALNNLGYIKLLQKQYDEALELLHQAA 502
                 89**********************96 PP

  == domain 6  score: -0.7 bits;  conditional E-value: 1.7
       TPR_2   2 ealynlGlayy 12 
                 +a yn+G++y+
  EFC38578.1 508 DAMYNIGNVYR 518
                 689******96 PP

  == domain 7  score: -1.2 bits;  conditional E-value: 2.3
       TPR_2  15 gdyeeAleafekAl 28 
                 ++ e A  ++++Al
  EFC38578.1 564 NRKEAASFYYKAAL 577
                 67899999999998 PP

  == domain 8  score: -0.8 bits;  conditional E-value: 1.8
       TPR_2   1 aealynlGlayy 12 
                 a+a++nlG  y+
  EFC38578.1 581 ADACNNLGIMYE 592
                 789*****9996 PP

  == domain 9  score: -0.5 bits;  conditional E-value: 1.4
       TPR_2  16 dyeeAleafekAlel 30 
                 d e+A+ +f+kA  l
  EFC38578.1 601 DEEKAVLWFRKASNL 615
                 6799*******9665 PP

  == domain 10  score: 11.0 bits;  conditional E-value: 0.00029
       TPR_2   4 lynlGlayyklgdyeeAleafekA 27 
                  +nl+ +y+++++ eeA  +++kA
  EFC38578.1 621 MFNLAAIYERRNKKEEATTLLRKA 644
                 79*********************9 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.064        81       7      33 .]     295     333 ..     289     333 .. 0.75
   2 ?   -0.1   0.0       1.4   1.8e+03       7      23 ..     410     430 ..     389     432 .. 0.67
   3 ?   -0.9   0.1       2.7   3.5e+03       5      19 ..     444     462 ..     440     468 .. 0.71
   4 ?    5.9   0.3     0.017        22       5      28 ..     480     503 ..     477     504 .. 0.86
   5 ?    0.9   0.0      0.71     9e+02       1      11 [.     508     518 ..     508     525 .. 0.91
   6 ?    4.5   0.1      0.05        63       3      25 ..     621     643 ..     619     644 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.064
                 HHHHHH.H..........HHHHHHHH.HHHHHHHH-TT- CS
       TPR_6   7 alsyrk.l..........gdtdkAle.alerlikeYPdS 33 
                 a+s++  +          +dt++ ++ +l++  ++YPdS
  EFC38578.1 295 ARSQYVvGtmliegvgveKDTRQGVKwTLKSAAQDYPDS 333
                 55555444666666777789999999************9 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 1.4
                 HHHHHHH....HHHHHHHHHH CS
       TPR_6   7 alsyrkl....gdtdkAleal 23 
                 +  ++k+     ++dkA+e++
  EFC38578.1 410 GVMFYKGlgieENPDKAVELF 430
                 444444346656888888887 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 2.7
                 HHHHHHHHH....HHHHHH CS
       TPR_6   5 klalsyrkl....gdtdkA 19 
                 +l+ +y+++     d++kA
  EFC38578.1 444 NLGIAYEEGkgvvRDYAKA 462
                 7999999976777777776 PP

  == domain 4  score: 5.9 bits;  conditional E-value: 0.017
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealerlik 28 
                 +l++  + ++++d+Ale+l +  +
  EFC38578.1 480 NLGYIKLLQKQYDEALELLHQAAD 503
                 5888899999*********99876 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.71
                 HHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyr 11 
                 dA+y+++  yr
  EFC38578.1 508 DAMYNIGNVYR 518
                 8******9997 PP

  == domain 6  score: 4.5 bits;  conditional E-value: 0.05
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   3 lyklalsyrklgdtdkAlealer 25 
                 +++la  y++ +++++A ++l++
  EFC38578.1 621 MFNLAAIYERRNKKEEATTLLRK 643
                 9*********98*****999987 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.5   0.00017      0.22       4      59 ..     458     510 ..     456     517 .. 0.86
   2 ?    3.9   0.0     0.048        61       6      49 ..     603     644 ..     599     654 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00017
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCTSHHHC-HHHH CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclylngqykrAyellrkaklnskslgcr 59 
                 +y +A +++e+    +  + +++  l++  +l++qy++A+ell++a  +  s+ + 
  EFC38578.1 458 DYAKATLCYEKSS--KLGNINALNNLGYIKLLQKQYDEALELLHQA-ADRGSIDAM 510
                 7999999999999..8899**************************9.555666555 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.048
                 HHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3   6 knAiflaerllaaetespedayllAlclylngqykrAyellrka 49 
                 ++A++++ ++   +  s++  + lA  + ++++ ++A +llrka
  EFC38578.1 603 EKAVLWFRKAS--NLGSDNGMFNLAAIYERRNKKEEATTLLRKA 644
                 67888888888..7777888888999999999999999999998 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.5         1   1.3e+03      16      30 ..     458     472 ..     440     472 .. 0.78
   2 !    9.1   0.4    0.0013       1.6       2      27 ..     476     501 ..     475     504 .. 0.88
   3 ?    0.8   0.0      0.57   7.3e+02       2      12 ..     508     518 ..     507     522 .. 0.80
   4 ?    1.8   0.1      0.28   3.6e+02      15      28 ..     564     577 ..     561     578 .. 0.88
   5 ?    1.9   0.0      0.26   3.3e+02      15      28 ..     600     613 ..     581     617 .. 0.76
   6 !    8.4   0.1    0.0022       2.8       4      28 ..     621     645 ..     618     647 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 1
                 -HHHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekalel 30 
                 dy +A  +yek  +l
  EFC38578.1 458 DYAKATLCYEKSSKL 472
                 899999999998775 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0013
                 CHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyeka 27 
                  a++nlg+i l +++y+eA e + +a
  EFC38578.1 476 NALNNLGYIKLLQKQYDEALELLHQA 501
                 589****************9987666 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.57
                 CHHHHHHHHHH CS
       TPR_8   2 eayynlgsiyl 12 
                 +a+yn+g++y+
  EFC38578.1 508 DAMYNIGNVYR 518
                 799*******4 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.28
                 T-HHHHHHHHHHHH CS
       TPR_8  15 gdyeeAkeyyekal 28 
                 +++e+A  yy+ al
  EFC38578.1 564 NRKEAASFYYKAAL 577
                 789********998 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.26
                 T-HHHHHHHHHHHH CS
       TPR_8  15 gdyeeAkeyyekal 28 
                 +d e+A+ +++ka 
  EFC38578.1 600 KDEEKAVLWFRKAS 613
                 78899999999986 PP

  == domain 6  score: 8.4 bits;  conditional E-value: 0.0022
                 HHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekal 28 
                 ++nl+ iy+  +++eeA   ++ka 
  EFC38578.1 621 MFNLAAIYERRNKKEEATTLLRKAS 645
                 69*********************96 PP

>> DUF5112  Domain of unknown function (DUF5112)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.1   1.7e-05     0.021      21      67 ..     458     504 ..     441     516 .. 0.87
   2 ?   -2.0   0.1       1.6     2e+03      34      46 ..     577     589 ..     566     594 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.7e-05
     DUF5112  21 laAekalklaegysagkaeAlNnlaFvaiarmdyeeaekllkeveek 67 
                  +A+ +l   ++ + g+ +AlNnl+++++++ +y+ea +ll++++++
  EFC38578.1 458 DYAKATLCYEKSSKLGNINALNNLGYIKLLQKQYDEALELLHQAADR 504
                 6788888888899999*************************998876 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.6
     DUF5112  34 sagkaeAlNnlaF 46 
                  +g a+A+Nnl+ 
  EFC38578.1 577 LNGDADACNNLGI 589
                 5789******986 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       1.8   2.3e+03      11      24 ..     329     342 ..     326     344 .. 0.87
   2 ?   -0.9   0.1       2.2   2.9e+03      16      25 ..     370     385 ..     366     391 .. 0.68
   3 ?   -0.6   0.0       1.8   2.4e+03       8      24 ..     398     414 ..     397     428 .. 0.64
   4 ?    6.0   3.8     0.014        18      12      34 .]     474     496 ..     431     496 .. 0.91
   5 ?    0.6   0.0      0.73   9.3e+02      12      24 ..     506     518 ..     501     545 .. 0.84
   6 ?   -2.6   0.1       7.5   9.6e+03      12      23 ..     580     591 ..     572     595 .. 0.73
   7 ?    5.2   0.0     0.025        32      16      32 ..     621     637 ..     616     638 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.8
      TPR_17  11 nnadaynnLAelll 24 
                 +++d++n+++ +++
  EFC38578.1 329 DYPDSLNQMGIFYE 342
                 789*******9997 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 2.2
      TPR_17  16 ynnLAelll......k 25 
                 ++n+A lll      k
  EFC38578.1 370 MTNYASLLLhgngveK 385
                 89*****995555533 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 1.8
      TPR_17   8 ldPnnadaynnLAelll 24 
                 ++ n+a+a n+L++ ++
  EFC38578.1 398 CERNYAKAQNELGVMFY 414
                 66789999999998543 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.014
      TPR_17  12 nadaynnLAelllknGdlmtArq 34 
                 n +a+nnL+++ l ++++++A++
  EFC38578.1 474 NINALNNLGYIKLLQKQYDEALE 496
                 68999**************9975 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.73
      TPR_17  12 nadaynnLAelll 24 
                 + da++n +++++
  EFC38578.1 506 SIDAMYNIGNVYR 518
                 5699*******97 PP

  == domain 6  score: -2.6 bits;  conditional E-value: 7.5
      TPR_17  12 nadaynnLAell 23 
                 +ada nnL+  +
  EFC38578.1 580 DADACNNLGIMY 591
                 677778888766 PP

  == domain 7  score: 5.2 bits;  conditional E-value: 0.025
      TPR_17  16 ynnLAelllknGdlmtA 32 
                 ++nLA ++++++++++A
  EFC38578.1 621 MFNLAAIYERRNKKEEA 637
                 8************9998 PP

>> TPR_3  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       1.3   1.7e+03      18      30 ..     424     434 ..     421     434 .. 0.81
   2 ?    8.7   0.6    0.0014       1.7      13      30 ..     487     502 ..     481     502 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.3
                 HHHHHH..HHHHH CS
       TPR_3  18 qeArelfsYalla 30 
                 ++A+el  + l+a
  EFC38578.1 424 DKAVEL--FTLSA 434
                 89****..55885 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0014
                 HTT-HHHHHHH..HHHHH CS
       TPR_3  13 nkkkyqeArelfsYalla 30 
                 ++k+y+eA+el++  ++a
  EFC38578.1 487 LQKQYDEALELLH--QAA 502
                 69*********99..875 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       6.3   8.1e+03      43      56 ..     285     299 ..     280     302 .. 0.66
   2 ?    0.9   0.1      0.58   7.4e+02      15      61 ..     389     434 ..     385     441 .. 0.78
   3 ?    0.8   0.0      0.63   8.1e+02      12      47 ..     422     452 ..     420     462 .. 0.75
   4 ?   11.4   0.1    0.0003      0.38       3      44 ..     481     517 ..     479     522 .. 0.85
   5 ?   -1.8   0.3         4   5.1e+03      32      61 ..     541     576 ..     535     583 .. 0.67
   6 ?   -1.2   0.0       2.7   3.4e+03      38      59 ..     622     643 ..     620     644 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 6.3
      TPR_16  43 aalrqgrlaeAa.al 56 
                 ++l++ rl eA+ ++
  EFC38578.1 285 LYLHAARLGEARsQY 299
                 566667777777444 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.58
      TPR_16  15 dAaaaleaalkrdpssPdaaeAllllgdaalrq....grlaeAaalyraal 61 
                 +Aa +l+ a +r+      a A+++lg+++++      + ++A++l+   +
  EFC38578.1 389 KAAWLLRKACERN-----YAKAQNELGVMFYKGlgieENPDKAVELFTLSA 434
                 5666677777777.....899*******99998888888888888887655 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.63
      TPR_16  12 dyddAaaaleaalkrdpssPdaaeAllllgdaalrq 47 
                 ++d+A+++++   +r      ++ Al++lg a+ + 
  EFC38578.1 422 NPDKAVELFTLSADR-----GNVYALNNLGIAYEEG 452
                 789999999444444.....499*******999875 PP

  == domain 4  score: 11.4 bits;  conditional E-value: 0.0003
      TPR_16   3 laraalragdyddAaaaleaalkrdpssPdaaeAllllgdaa 44 
                 l+++ l +++yd+A+++l++a +r+       +A+++ g+++
  EFC38578.1 481 LGYIKLLQKQYDEALELLHQAADRG-----SIDAMYNIGNVY 517
                 666677799****************.....559999999987 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 4
      TPR_16  32 daaeAllllgdaalrq......grlaeAaalyraal 61 
                  ++ A+ l gd+++        ++ +eAa +y +a+
  EFC38578.1 541 GHHKAQKLVGDILYSGvgeaipSNRKEAASFYYKAA 576
                 577777888888887777777777788886666654 PP

  == domain 6  score: -1.2 bits;  conditional E-value: 2.7
      TPR_16  38 lllgdaalrqgrlaeAaalyra 59 
                 ++l+ ++ r++  +eA  l+r+
  EFC38578.1 622 FNLAAIYERRNKKEEATTLLRK 643
                 6788888888777777666665 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       9.8   1.2e+04      14      24 ..     323     333 ..     322     335 .. 0.80
   2 ?   -0.9   0.0       1.9   2.4e+03       4      35 ..     420     449 ..     419     453 .. 0.78
   3 ?    9.0   0.2    0.0016         2       2      21 ..     486     503 ..     457     517 .. 0.62
   4 ?   -0.5   0.0       1.4   1.8e+03      29      50 ..     622     643 ..     604     646 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 9.8
      TPR_19  14 leqalqedpkn 24 
                 l++a q++p++
  EFC38578.1 323 LKSAAQDYPDS 333
                 78999999986 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.9
      TPR_19   4 egdyaeAlalleqalqedpknaearllLAeal 35 
                 e++++ A++l++   ++d +n +a+ +L +a+
  EFC38578.1 420 EENPDKAVELFTL--SADRGNVYALNNLGIAY 449
                 5677888888876..57889999999999988 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.0016
      TPR_19   2 laegdyaeAlalleqalqed 21 
                 l +++y+eAl+ll qa  +d
  EFC38578.1 486 LLQKQYDEALELLHQA--AD 503
                 3355555555555555..33 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 1.4
      TPR_19  29 llLAeallalgqldeAealLda 50 
                  +LA ++   +  +eA  lL +
  EFC38578.1 622 FNLAAIYERRNKKEEATTLLRK 643
                 56899999********999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (663 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       893  (0.0498076); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.47
# Mc/sec: 4270.95
//
Query:       EFC38579.1  [L=527]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.2e-18   67.4   8.6    3.6e-18   65.8   3.8    3.6  4  TAFII55_N  TAFII55 protein conserved region
     0.0019   18.0   0.3     0.0044   16.8   0.3    1.5  1  Arc        Arc-like DNA binding domain
  ------ inclusion threshold ------
      0.021   14.8   0.3      0.075   13.0   0.3    1.9  1  RHH_1      Ribbon-helix-helix protein, copG family


Domain annotation for each model (and alignments):
>> TAFII55_N  TAFII55 protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.7   4.2         3   1.8e+04      96     105 ..      21      30 ..       5      51 .. 0.43
   2 !   12.4   0.2   1.6e-05     0.093       2      28 ..      58      92 ..      57     111 .. 0.78
   3 !   65.8   3.8   6.1e-22   3.6e-18      28     156 ..     134     283 ..     111     287 .. 0.75
   4 ?   -3.0   0.1      0.88   5.3e+03      28      66 ..     472     511 ..     455     513 .. 0.64

  Alignments for each domain:
  == domain 1  score: -4.7 bits;  conditional E-value: 3
   TAFII55_N  96 eleeekskkk 105
                 ++e+++++++
  EFC38579.1  21 KKESKDKSES 30 
                 1111111111 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 1.6e-05
   TAFII55_N  2 EeqfiLRlppeeaeklreaiesgdvn........k 28
                E+qf+LR+p++ aek+re i++++ +         
  EFC38579.1 58 EKQFVLRVPEDIAEKIRERIRKESKSssekaqrvG 92
                89*******************99976666544333 PP

  == domain 3  score: 65.8 bits;  conditional E-value: 6.1e-22
   TAFII55_N  28 kdklsiklekderravvkidgklyaaklvDLPtiiEslKtiDkknlyKtaDisqmllvkeeeeakkeeeleeeks....................kkkk 106
                  ++++  + +++rr+ +++++k++  +lvD+Pt +E++K+iD +++yK+ D+sqm+lv+++++ ++  ++++  +                    +kk+
  EFC38579.1 134 LSDIEYGI-DKNRRGRFQFGDKILPCVLVDMPTHVEAYKSIDCQTYYKCGDVSQMILVQKPSDLEADIQKSRV-KrnkcyqknsnnkthhhhhhdSKKR 230
                 56677777.889**********************************************555555444332222.1346677788888999998865555 PP

   TAFII55_N 107 kekkkekkfqyphGitpPlknvrkrRFrkr..lkkkeiea.vekevkrLlraD 156
                 k+k+  +++ +++G+t P++ v ++   ++  +++k i++  ek ++ L ++D
  EFC38579.1 231 KTKDLLTSYLFEDGLTSPMERVLRHWNSQKleITRKDIKKlKEKYIQMLEEED 283
                 55778999**************6654444311556777777888888777777 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 0.88
   TAFII55_N  28 kdklsikl.ekderravvkidgklyaaklvDLPtiiEslK 66 
                 +++ +ikl +++  +a   i+++  +a +  L  i+  +K
  EFC38579.1 472 ENESKIKLvQTNIGKAKNDIQKQRANAAIASLGDIVQDHK 511
                 4455566555666677777777777777777777766665 PP

>> Arc  Arc-like DNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.3   7.4e-07    0.0044       5      38 ..      59      91 ..      56      95 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 7.4e-07
                EEEEEECEHHHHHHHHHHHHHTTS-HHHHHHHHH CS
         Arc  5 pkFnlRlPeevrekvkevAeengRSmNSEilqrv 38
                 +F+lR Pe++ ek++e+ ++   S  SE  qrv
  EFC38579.1 59 KQFVLRVPEDIAEKIRERIRKESKS-SSEKAQRV 91
                69******************99998.47777776 PP

>> RHH_1  Ribbon-helix-helix protein, copG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.3   1.2e-05     0.075       4      27 ..      63      86 ..      61      86 .. 0.95

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
                EEEEHHHHHHHHHHHHHHTSSHHH CS
       RHH_1  4 irldeellerLdelarrrgrSrSe 27
                +r++e+++e+++e++r++ +S Se
  EFC38579.1 63 LRVPEDIAEKIRERIRKESKSSSE 86
                59********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (527 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3144  (0.175358); expected 358.6 (0.02)
Passed bias filter:                      708  (0.0394891); expected 358.6 (0.02)
Passed Vit filter:                        98  (0.005466); expected 17.9 (0.001)
Passed Fwd filter:                        33  (0.00184059); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.96u 0.39s 00:00:01.35 Elapsed: 00:00:00.59
# Mc/sec: 2699.18
//
Query:       EFC38580.1  [L=598]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.3e-31  108.1   0.0    6.2e-31  107.6   0.0    1.2  1  ATP_bind_3  PP-loop family


Domain annotation for each model (and alignments):
>> ATP_bind_3  PP-loop family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.6   0.0   3.5e-35   6.2e-31       2     181 ..     122     312 ..     121     313 .. 0.91

  Alignments for each domain:
  == domain 1  score: 107.6 bits;  conditional E-value: 3.5e-35
                 EEEE--SCHHHHHHHHHHHHHCTTTTT......EEEEEEEE-SSSTCHHHHHHHHHHHHHHTT..-EEEEEE--HHHCTTSTCCCHHHHHHHHHHHHCH CS
  ATP_bind_3   2 vlvAvSgGlDSmaLllllaklkkklgi......klvaihvdhglreeskeeaelvkelckkln..ikleiekvdvakkkgknleeaARelRYevlkeal 92 
                 v vAvSgG DSm    l++k+++ l+       ++va+ vdh++rees++e+ +v+e+ +k     +++  ++ +   ++k+ +  AR +R  ++++ +
  EFC38580.1 122 VGVAVSGGGDSMGTAILVKKWADYLKQkkgidmEVVALIVDHQIREESEHEMLYVHEVLTKTVgyKNVFCFQCLWPD-NQKKQQRIARLKRQLIMSSEC 219
                 789*****************9988777888899***********************998776433556667777765.478999*************** PP

                 HCCT.CEEE---BHHHHHHHHHHHHCCT--CCHHH-S-SEEEE....TTCCEE-CCCT--HHHHHHHHHHTT---B--CGGGCTTSHHHHHHH CS
  ATP_bind_3  93 kkegievlllAhhadDqaEtfllrlargsglaglagikeasei....asirlvRPlLkvskeeleeylkekkikwveDesNadekyeRnriRk 181
                  +++i++l+ +hh++D +Et+++r+a +sg++gl gi+   ++    a+i l RP L +  +el++++ + +ikwveD+ N+de+  R +iR 
  EFC38580.1 220 VSQKIDLLISGHHKQDNIETMIHRVAFSSGINGLNGIPLIYSYcvadATIMLARPGLVFDCNELKAVCTQYNIKWVEDPKNSDEREFRSIIRS 312
                 *************************************998877788788*******************************************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (598 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       616  (0.0343577); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.28s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 3704.26
//
Query:       EFC38581.1  [L=728]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   12.6   0.2       0.13   12.6   0.2    2.4  2  AAA       ATPase family associated with various cellular acti


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.8      0.11   2.1e+03      44      98 ..     112     166 ..      82     189 .. 0.65
   2 ?   12.6   0.2   7.5e-06      0.13       3     111 ..     480     573 ..     478     589 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.11
                 HHHHHHHHHHHHTSTS.EEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  44 kkirelfkeakekakp.silfiDEidalaksrsgseseeeervvnqLlteldgvkk 98 
                 kk  e +k+ +++ ++  ++ +DE + + ++  ++++e   +v++ +lt+ ++++k
  EFC38581.1 112 KKKTESVKRKRTNDNCeEVVDVDESHFISTKG-KQTDEIIGSVASIFLTKEQRQRK 166
                 33333344434444344899999999998887.55555666666666665555544 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 7.5e-06
                 EESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTS..TS.EEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA   3 lyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakeka..kp.silfiDEidalaksrsgseseeeervvnqLlteldgvkk 98 
                 lyG    GK++   a+a++lg+e++e++ +  +      s+k+i el ++ ++k   +  +i++++++d  ++++            + L++++++++k
  EFC38581.1 480 LYGST-SGKSSSLCAIATQLGFEIMEVNSACDR------SSKSIMELKETTQSKGinSMgKIIVFEDADLKFQEE----------SYPSLISAIEKLEK 561
                 55543.7*********************99999......5555555555544444543459999****9999888..........78999999999999 PP

                 SSSTEEEEEEESS CS
         AAA  99 keskvivigatnr 111
                 +++   +i+++ +
  EFC38581.1 562 STK-RPIILISDN 573
                 755.555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (728 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2270  (0.126611); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.82u 0.34s 00:00:01.15 Elapsed: 00:00:00.54
# Mc/sec: 4045.52
//
Query:       EFC38582.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
   8.4e-145  483.1   8.2   9.5e-145  483.0   8.2    1.0  1  Cpn60_TCP1  TCP-1/cpn60 chaperonin family
  ------ inclusion threshold ------
      0.045   14.0   0.2        0.5   10.7   0.1    2.3  2  DUF356      Protein of unknown function (DUF356)
       0.11   12.5   0.8       0.75    9.8   0.0    2.4  2  DUF892      Domain of unknown function (DUF892)


Domain annotation for each model (and alignments):
>> Cpn60_TCP1  TCP-1/cpn60 chaperonin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  483.0   8.2  1.6e-148  9.5e-145       1     490 [.      42     532 ..      42     533 .. 0.98

  Alignments for each domain:
  == domain 1  score: 483.0 bits;  conditional E-value: 1.6e-148
                 HHHHHHCCSSTTXXEEEEEETTSEEEEEXSHHHHHHCSXXXSHHHHHHHHHHHHCCCCCTTCHHHHHHHHHHHHHHHHHHHHCTXXHHHHHHHHHHHHH CS
  Cpn60_TCP1   1 ladivkttlGPkGmdKmlvnkggkvvvTnDGatilkeleiehPaakllveaaesqdeevGDGTttvviLageLleeaekliaagvhpttiiegyekale 99 
                 l++iv+t++GP+Gm+K++vn+ +k+++++D ati+kele+ hPaak++v a ++q++e+GDGT++v+ ++geLl ++e+li++g+h+ +i  gy+ka +
  EFC38582.1  42 LSKIVRTSMGPNGMNKIVVNHLEKLFISKDTATIMKELEVIHPAAKIIVLATQAQEQEAGDGTNFVCCFTGELLAQSETLIRMGLHIPDILLGYKKAGA 140
                 799************************************************************************************************ PP

                 HHHHHHHHHXEEBXSCSTT.HHHHHHHHHHCTTSSXXSTHHHHHHHHHHHH.HCHCCCSEECSCCCEECCCCEECECTTSEEESEEEESS--SSTTSSC CS
  Cpn60_TCP1 100 kaleaLkeiaveisseekdreeLlkvartslsskltskeaeelsklvvdAv.klieenekeldlgrikvvkieggsledselveGlvldkgvlspdmpk 197
                 kal+ L+   v+  s+ ++ +e+ k +  +++sk+   e ++l+ l+++A+ ++++++++++++++i++ ki ggs+ ds++++G+++ ++  ++   k
  EFC38582.1 141 KALQVLETLGVKEVSDIRNLDEVTKSIGATIGSKVLGME-DFLAPLIAEACiSVCPKTASRFNIDNIRTAKIPGGSVYDSKVLKGFAFVRDSEGS--IK 236
                 ******99988888889999******************9.***************************************************9999..9* PP

                 EEECEEEEEESS-BS--HHCCHHHCCCCSCCHHHHHHHHHHHHHHHHHHHHHHTTECEEEESS-B-HHHHHHHHHCT-EEE-S--HHHHHHHHHHHT-- CS
  Cpn60_TCP1 198 klenakvllldvsLeiektetkttvvlsdaeeleklekaeekqleellekiiksgvnvvvcqkgiddlalhflakngilalrrvkkkdlerlakatGat 296
                 +++n+kv+++++ ++ ++tetk +vv+++ eel ++  +eek +ee +++i++sgv+v+v+q+g+ ++alhf +++g++a++  +k++++rl++a+Ga+
  EFC38582.1 237 HVKNCKVAVYTCNIDQTSTETKNSVVIRSSEELLNYNLSEEKAMEEEIKAIADSGVKVIVSQGGFGEMALHFIEQHGMMAIKCPSKFQVQRLCQAIGAR 335
                 *************************************************************************************************** PP

                 EBSCGGGGGCGC-EEEEEEEECCETTCCEEEEE...CESSSSXEEEEEEESTCCCHHHHHHHHHHHHHHHHHHHHHHEEEETTTCHHHHHHHHHHCCCC CS
  Cpn60_TCP1 297 avssledltpeelGtakkveeekigsekttiie...evksgkiatillrgatdtvldeieraiedAlnvvknaiedekvvpGGGatelelakklkeyak 392
                 ++ +l  +tp+++Gta+ v  ++ig++k+ +++   +v+ ++iati++rgat +v+de+era++d++n++k++ +d ++++G+Ga+e++l+++l++ya+
  EFC38582.1 336 MLVKLVPPTPDDMGTASAVDITEIGDKKVALFQqaeDVDVSGIATIIIRGATANVMDEVERAVDDGVNAFKSLAKDARLLAGAGAVEVALYNELSKYAD 434
                 *********************************66666899********************************************************** PP

                 TSXCCHHHHHHHHHHHHTHHHHHHHHHCTSXHHHHHHHHHHHHHTTXTTEEEETTTTCEEECCCCTXEEEHHHHHHHHHHHHHHHHHHHCEEEEEXXX CS
  Cpn60_TCP1 393 svsgeeqlaieafakALevipktLaeNaGldpievlaklraahnkgekelgidvesgeiidlveagvvDplkvkrqalksAteaastiLrideiikak 490
                 +++g eq+ai++fa+A++v+p+tLae aGld+   +++l+aah++g++++gid+ + +  d++e++++D l++k +++k++t+aa  iL++d+ii+a+
  EFC38582.1 435 ETPGLEQYAIRKFAEAFLVVPRTLAESAGLDSSIAISNLTAAHAEGKTTWGIDISDISGLDAKENNIFDLLSTKYWGVKLCTDAAINILSVDQIIMAR 532
                 ************************************************************************************************97 PP

>> DUF356  Protein of unknown function (DUF356)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   8.4e-05       0.5      62      91 ..      67      96 ..      31     100 .. 0.79
   2 ?    0.4   0.0      0.13     8e+02      14      33 ..     304     323 ..     302     364 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 8.4e-05
      DUF356 62 eveedatkaisklrkiHPPaHvvvvseeyd 91
                 +++d+++++++l+ iHP a ++v++ + +
  EFC38582.1 67 FISKDTATIMKELEVIHPAAKIIVLATQAQ 96
                47899999999*************998765 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.13
      DUF356  14 nalaDlerygklkiegkPri 33 
                 +al+ +e++g + i+   + 
  EFC38582.1 304 MALHFIEQHGMMAIKCPSKF 323
                 69999*******99876554 PP

>> DUF892  Domain of unknown function (DUF892)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00013      0.75     127     155 ..     265     293 ..     232     296 .. 0.81
   2 ?   -0.0   0.1      0.13   7.9e+02      75     122 ..     389     435 ..     375     446 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00013
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      DUF892 127 eaaklLeqtleeekatdekltelaeslvn 155
                 +  +lL+++l eeka++e ++++a+s+v+
  EFC38582.1 265 SSEELLNYNLSEEKAMEEEIKAIADSGVK 293
                 5689********************99886 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.13
                 HTTT-----------..THHHHHHH...HHHHHHHHHHHHHHHHHHHHHC CS
      DUF892  75 gliaegqelieeaae..deslkdaaliaaaqavehyEiAsYgtLialAeq 122
                 +++ e++ ++++ ++  ++ +kda l+a a av   E+A Y+ L ++A++
  EFC38582.1 389 NVMDEVERAVDDGVNafKSLAKDARLLAGAGAV---EVALYNELSKYADE 435
                 455555555544433114568999988888887...68999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       520  (0.0290033); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 3323.18
//
Query:       EFC38583.1  [L=486]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-46  158.7   0.0    1.7e-46  158.2   0.0    1.2  1  RimK             RimK-like ATP-grasp domain
    2.3e-14   53.2   0.1    3.8e-14   52.5   0.1    1.2  1  GSH-S_ATP        Prokaryotic glutathione synthetase, ATP-gras
    7.6e-14   51.9   0.0    1.6e-13   50.9   0.0    1.5  1  Rimk_N           RimK PreATP-grasp domain
    3.3e-10   40.2   0.0    7.4e-10   39.1   0.0    1.6  1  ATP-grasp_3      ATP-grasp domain
    2.5e-09   36.8   0.6     0.0014   17.9   0.6    3.2  2  ATPgrasp_ST      Sugar-transfer associated ATP-grasp
    4.6e-06   26.3   0.1      2e-05   24.3   0.0    2.0  2  ATP-grasp        ATP-grasp domain
    1.5e-05   24.4   1.2      0.022   14.0   1.2    3.2  1  ATPgrasp_YheCD   YheC/D like ATP-grasp
    8.3e-05   21.8   2.0     0.0096   15.1   0.1    2.8  3  TTL              Tubulin-tyrosine ligase family
    0.00011   21.8   0.1     0.0017   17.9   0.1    2.3  1  Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
  ------ inclusion threshold ------
      0.026   14.0   0.0      0.046   13.2   0.0    1.4  1  CPSase_L_D2      Carbamoyl-phosphate synthase L chain, ATP bi
       0.13   11.8   0.0       0.21   11.1   0.0    1.3  1  Synapsin_C       Synapsin, ATP binding domain


Domain annotation for each model (and alignments):
>> RimK  RimK-like ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.2   0.0     1e-49   1.7e-46       1     186 [.     247     431 ..     247     433 .. 0.95

  Alignments for each domain:
  == domain 1  score: 158.2 bits;  conditional E-value: 1e-49
                 HH-HHHHHHHHHHTT-----EEEESS-S-HHHHHHTT-.-SSEEEEE-TTTT--EEEEE-SHHHHHHHHHH..GGG--EEEEE--SS-SEEEEEEEETT CS
        RimK   1 ardKlkslklLakakikvpntalardeedaekliekiklrfPvvvKsvegsqGikvvlakkeqklkqvlea..lkeailvqeyieeaenediRvlvvdd 97 
                 +rdKl++l+ Lak++i++p+t +ar + +++ +i +  +  P+++K++ gsqG +v+l + e+++k + +   + +++++qe+i+ ++++diRv+vv++
  EFC38583.1 247 TRDKLQTLQQLAKDQIPIPKTMIARFPLETS-IISRH-FTYPIILKKSSGSQGKGVMLIESENQIKGLDDMldVSKSMIIQEFIQASKGRDIRVIVVGG 343
                 69*************************9886.45554.79**************************9966577899*********************** PP

                 EEEEEEEEE--SSS----TTTT-EEEE----HHHHHHHHHHHHHCT-SEEEEEEEEETTEEEEEEEESS--SHHHHHHHT--HHHHHHH CS
        RimK  98 evvaalrrvskeGdFRsnlhrGgvaeklqlseeekelAikaakamelvvaGvDllrakrgllvlEvnsspglekiektlgidiakklie 186
                 + ++a+ rv+k   F+sn h+Gg +++++ls  ++ lAi+aa+ ++l++aGvD+l  k+ + ++E+nsspg e++e  +g+++ +++++
  EFC38583.1 344 KAIGAMMRVAKS-GFKSNFHQGGWVKPVKLSSSLEWLAITAAQSVDLDFAGVDILIDKDTYKICEINSSPGFEGFELATGLNVPEQFLN 431
                 *********999.6*********************************************************************999876 PP

>> GSH-S_ATP  Prokaryotic glutathione synthetase, ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.5   0.1   2.4e-17   3.8e-14      12     160 ..     264     409 ..     250     415 .. 0.84

  Alignments for each domain:
  == domain 1  score: 52.5 bits;  conditional E-value: 2.4e-17
                 S--EEEES-HHHHHHHHHHHSS.EEEEESS--TTTT-EEE-TT-TTHHHHHHHHTTTTTS-EEEEE--GGGGG-EEEEEEETTEE-SEEEEEE--SS-S CS
   GSH-S_ATP  12 ipktlvskdkeeirafleeqgd.vilKPldgkgGegvfrvkksdpnlksilellteegkepviaqrylpeikeGDkRillvdGepigyalaRvpaegev 109
                 ipkt++++   e + + ++    +ilK  +g+ G+gv+ +++ ++++k + ++l  +++  +i+q+++++ k  D R+++v G+ ig a+ Rv+++g +
  EFC38583.1 264 IPKTMIARFPLETSIISRHFTYpIILKKSSGSQGKGVMLIES-ENQIKGLDDMLDVSKS--MIIQEFIQASKGRDIRVIVVGGKAIG-AMMRVAKSG-F 357
                 68888888887777777766656***************9987.6789999888876655..9*************************.*****8765.9 PP

                 ---GGGTSCEEEEE--HHHHHHHHHHHHHHHHTT--EEEEEEETT....EEEEEE CS
   GSH-S_ATP 110 RsnlaaggraeatelterdreiaeelapkLkekGllfvGlDvigd....kltEin 160
                 +sn++ gg ++ ++l+++ +++a + a+++    l f+G+D++ d    k+ Ein
  EFC38583.1 358 KSNFHQGGWVKPVKLSSSLEWLAITAAQSVD---LDFAGVDILIDkdtyKICEIN 409
                 ***********************99888765...77*****98662333477777 PP

>> Rimk_N  RimK PreATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.9   0.0   9.5e-17   1.6e-13      12      90 ..     158     240 ..     142     244 .. 0.89

  Alignments for each domain:
  == domain 1  score: 50.9 bits;  conditional E-value: 9.5e-17
      Rimk_N  12 lystrrLveaaekrghevevldplrcylkiea.ekpevyykgeklee...fdavipRigasitfygtavlrqFemmgvfvlne 90 
                  ys rr+ e a +r+++ve++++++++l +++ ++++++y+ge +++    d+v+pR+ga i + g+av+rqFe+m+v vln 
  EFC38583.1 158 TYSARRFFETAWRRNIQVELMEIQKFDLLVSHdGSNSLIYDGEVVPRdefPDVVLPRLGAHIDYWGLAVVRQFEKMDVLVLNG 240
                 5**************************9998626789*****777554448******************************96 PP

>> ATP-grasp_3  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.1   0.0   4.5e-13   7.4e-10       2     156 ..     248     410 ..     247     413 .. 0.75

  Alignments for each domain:
  == domain 1  score: 39.1 bits;  conditional E-value: 4.5e-13
                  TSHHHHHHHHTTT.S---..........-EESS--.......SSSEEEEESS-------B--SS--TTE............EEEE---...SEEEEEE CS
  ATP-grasp_3   2 sdKlktykkLkeagvkvP......tkleaeeleee.......ekklvvKprdGaggesvrvveekeeaeaaieeve.....lvqefie...GkplSvs 78 
                   dKl+t ++L + ++++P        le               +++++K+++G+ g++v+++e +++ +   +++      ++qefi+   G+++ v 
   EFC38583.1 248 RDKLQTLQQLAKDQIPIPktmiarFPLE------TsiisrhfTYPIILKKSSGSQGKGVMLIESENQIKGLDDMLDvsksmIIQEFIQaskGRDIRVI 339
                  69****************5444333333......245556689********************998876443333356778******64337888888 PP

                  EEE.SSSEEEEEEEEEEEET....TEEEEEEES----HHHHHHHHHHHHHTTSTT--EEEEEEEEESS.SEEEEEEES CS
  ATP-grasp_3  79 llsdgekvlvlavnrqliekaekefvyaGnvtpietelkeevvelaeevvekleglaGyvGvDlvlkdeepyviEvNP 156
                  +++ +    ++ v +   +    +f   G v p++  l+++++ la  + +++ +l  ++GvD+++ ++   + E+N+
   EFC38583.1 340 VVGGKAIGAMMRVAKSGFKS---NFHQGGWVKPVK--LSSSLEWLAITAAQSV-DL-DFAGVDILIDKDTYKICEINS 410
                  88866555666666666543...355555555555..8889999999999999.55.69*********999******7 PP

>> ATPgrasp_ST  Sugar-transfer associated ATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.6   8.6e-07    0.0014      16     183 ..     244     367 ..     236     376 .. 0.70
   2 !   10.3   0.0   0.00018       0.3     231     279 ..     379     425 ..     374     433 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 8.6e-07
  ATPgrasp_ST  16 fplvddKlkfkelalraglkvpkllgvikeqaeiseleafvkeleeg.vviKpakgsgGkGilviteredqdylkssgksalldelerhvsnilagLy 112
                  +++  dKl++ + + ++ +++pk+++       +    ++++++ +  +++K   gs GkG++ i + e        ++   ld++  +v        
   EFC38583.1 244 LEMTRDKLQTLQQLAKDQIPIPKTMIA-----RFPLETSIISRHFTYpIILKKSSGSQGKGVMLIES-E--------NQIKGLDDML-DV-------- 318
                  56778***999999*********5443.....22222333333333359****************55.2........2222233333.12........ PP

  ATPgrasp_ST 113 slggkpdvalveelikqdpeleklspesvntiRvitflkdkkvevmlamlRlgtkaskvDgkaNlhqGgvg 183
                       ++ ++++e+i+ ++        +  +iRvi++    +  +  am+R++ ++     k N+hqGg +
   EFC38583.1 319 -----SKSMIIQEFIQASK--------G-RDIRVIVV---GGKAI-GAMMRVAKSGF----KSNFHQGGWV 367
                  .....2579******9864........5.8*******...55555.5******9998....679****965 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00018
  ATPgrasp_ST 231 laakaaeklpglgylGwDivldeekgplllElNarpglaivqiangegl 279
                  la  aa+  + l   G+Di +d++    + E+N  pg + +++a g  +
   EFC38583.1 379 LAITAAQ-SVDLDFAGVDILIDKDT-YKICEINSSPGFEGFELATGLNV 425
                  6777888.899**************.9***************9988665 PP

>> ATP-grasp  ATP-grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.97   1.6e+03      86     121 ..      22      58 ..      17      71 .. 0.60
   2 !   24.3   0.0   1.2e-08     2e-05       3      84 ..     259     342 ..     257     393 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.97
                 TTC-EEE--EEEEEEE.TTEEEEEEECEE-SCHHHHH CS
   ATP-grasp  86 aeGetafypvvetvqe.dgilrlsvapaevsekaqkk 121
                 +eG +++ p++++ +e dg   +  a+ +v+e++ ++
  EFC38583.1  22 QEGLVSTTPPTHHDEEnDGETTTITASVTVKEEDSNQ 58 
                 5787888888877654156666666666666664333 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 1.2e-08
                 TTT--B-EEEEECCHHHHHHHHHHH-SCEEEEESSS-CTTTTEEEECTCCGHHCHHHHC.GTTCEEEEE----S..EEEEEEEEE CS
   ATP-grasp   3 klglpvprflaveskeeleeaaeelglpvvvKarrlgydGkGqsvvrseedleqaleal.keekvivEefvpfe..kElsvlvvr 84 
                 k ++p+p+ ++++   e++ + +++ +p+++K +  g+ GkG ++++se++++ + ++l  ++++i+ ef++ +  + + v+vv 
  EFC38583.1 259 KDQIPIPKTMIARFPLETSIISRHFTYPIILK-KSSGSQGKGVMLIESENQIKGLDDMLdVSKSMIIQEFIQASkgRDIRVIVVG 342
                 67899999999999999999************.999*********************9977899*******87622467777665 PP

>> ATPgrasp_YheCD  YheC/D like ATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   1.2   1.4e-05     0.022      12     233 ..     250     417 ..     245     432 .. 0.64

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.4e-05
  ATPgrasp_YheCD  12 KwevyelLskdpelrpyLPetellesledleemlekyks..vylKpanGskGkgilriekeekellllsrekkkkkkkrlaslselesllkkllk 104
                     K ++ + L+kd+     +P+t    ++    ++++++ +  ++lK ++Gs+Gkg++ ie+                +++++    l  +l+  + 
      EFC38583.1 250 KLQTLQQLAKDQ---IPIPKTMIA-RFPLETSIISRHFTypIILKKSSGSQGKGVMLIES----------------ENQIK---GLDDMLD--V- 318
                     555555555554...557777776.55555556666655569******************................23333...3444444..2. PP

  ATPgrasp_YheCD 105 kkrylvQqgidlatidgrpfDfRvlvqKngkgkWevtgiaaRiagkgsittnlsrGGtalpleellkkafgeekaekileeleelalelaealee 199
                     +k++++Q+ i+ ++      D+Rv+v        + +g+++R+a++g + +n+++GG ++p++              + ++le la+++a+ ++ 
      EFC38583.1 319 SKSMIIQEFIQASK----GRDIRVIVVGG-----KAIGAMMRVAKSG-FKSNFHQGGWVKPVK--------------LSSSLEWLAITAAQSVDL 389
                     33578888888776....44888888833.....3578888888665.888888888777764..............344556666666666665 PP

  ATPgrasp_YheCD 200 sfgrlgElGlDlgidkegkvWllEvNskpgrsif 233
                      f      G+D+ idk+  + + E+Ns pg + f
      EFC38583.1 390 DFA-----GVDILIDKD-TYKICEINSSPGFEGF 417
                     555.....666666665.3556666666666665 PP

>> TTL  Tubulin-tyrosine ligase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.2      0.71   1.2e+03      67      94 ..      81     109 ..      38     139 .. 0.63
   2 !   15.1   0.1   5.9e-06    0.0096      68     110 ..     286     329 ..     234     341 .. 0.84
   3 !    5.3   0.0    0.0058       9.4     240     263 ..     392     414 ..     383     420 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.71
                 B----SS---X.X------BSSTHHHHHH CS
         TTL  67 ntwIvKpsasa.rGkgirvfnkledikki 94 
                 ++   Kp++++ r ++i++ ++ e+ + +
  EFC38583.1  81 QVTTGKPKNKSkRTIQITIPKDYEKYQLK 109
                 45555777654256677777777777644 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 5.9e-06
                 ----SS---XX------BSSTHHHHHH.HH..SSS-EEEEB--S CS
         TTL  68 twIvKpsasarGkgirvfnkledikki.vsqsqkeplvvqkYie 110
                   I+K+s++++Gkg++++++ ++ik + +    ++++++q++i+
  EFC38583.1 286 PIILKKSSGSQGKGVMLIESENQIKGLdDMLDVSKSMIIQEFIQ 329
                 579**********************99655567899*******7 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.0058
                 XXXXXXXXXXXXXXXXXXXXXX.. CS
         TTL 240 yGvDilidenlkpwLlEvNasPdl 263
                  GvDilid+++  ++ E+N+sP +
  EFC38583.1 392 AGVDILIDKDTY-KICEINSSPGF 414
                 69********87.899******87 PP

>> Dala_Dala_lig_C  D-ala D-ala ligase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.1     1e-06    0.0017      31     179 ..     279     415 ..     270     422 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 1e-06
                      HHHHC-SSEEEEESSSSTTTTEEEESSGGGHHHHHHHHHTT-SCEEEEE--...ESEEEEEEEEETSSCEEEEEEEEE-SSSSS-HHHHHC.TT CS
  Dala_Dala_lig_C  31 veeelgypvfVKpareGSSvGvskveseeelkeaieeafkydekvlvEeai...egreievavlgneklevsevgeivvkkgfydyeakysddk 121
                      +  +++yp++ K +      Gv  +ese+++k  +++ +   +++++ e+i   +gr+i v v+g    ++  +  +v+k+gf   +  +  ++
       EFC38583.1 279 ISRHFTYPIILKKSSGSQGKGVMLIESENQIK-GLDDMLDVSKSMIIQEFIqasKGRDIRVIVVG---GKAIGAMMRVAKSGF---KSNF--HQ 363
                      56789********9988899**********97.589*************9976678*********...667777777777765...6667..45 PP

                      -EEESS----HHHHHHHHHHHHHHHHHTT--SEEEEEEEEETTTEEEEEEEESS---S CS
  Dala_Dala_lig_C 122 aqlevpaklekeveekiqelalkaykaldlrGlaRvDfflteegeivlnEvNtlPGfT 179
                         + p+kl+    ++++ la+ a + +dl ++a vD++++ +++  + E+N  PGf 
       EFC38583.1 364 GGWVKPVKLS----SSLEWLAITAAQSVDL-DFAGVDILID-KDTYKICEINSSPGFE 415
                      6666777665....5678999999999*98.7999*****9.78999*********95 PP

>> CPSase_L_D2  Carbamoyl-phosphate synthase L chain, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   2.8e-05     0.046       1      66 [.     249     312 ..     249     349 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.8e-05
                  SHHHHHHHHHHTT-BBSSEECSSBSSHHHHHHHHHHH-SSEEEEETTCCTTTTEEEESSHHHHHHH CS
  CPSase_L_D2   1 DkesakealkkinvpvvpssaapvetleealaiakeigyPviikaafglGGkGmrvarneeelael 66 
                  Dk +  ++l+k ++p+ + ++a  +   e+  i++++ yP+i+k + g  GkG  ++++e++++ l
   EFC38583.1 249 DKLQTLQQLAKDQIPIPKTMIA--RFPLETSIISRHFTYPIILKKSSGSQGKGVMLIESENQIKGL 312
                  6666677777788888888877..5566777899***********************999988654 PP

>> Synapsin_C  Synapsin, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00013      0.21      40     125 ..     273     360 ..     249     409 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00013
  Synapsin_C  40 pnhkemlt.lptfpvvvklghahagmgkvkvenqydyqdiasvvalaktyataeafidsk.ydirvqkig.snykaymrtsisgnwkan 125
                 p    +++   t+p+++k      g g + +e + + + +  ++ ++k+    e +  sk  dirv  +g +   a mr + sg  k+n
  EFC38583.1 273 PLETSIISrHFTYPIILKKSSGSQGKGVMLIESENQIKGLDDMLDVSKSMIIQEFIQASKgRDIRVIVVGgKAIGAMMRVAKSGF-KSN 360
                 5555554414589*************************************999977778856****9997256789999999984.444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1402  (0.0781973); expected 358.6 (0.02)
Passed bias filter:                      685  (0.0382063); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 2893.69
//
Query:       EFC38584.1  [L=888]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.17   11.8   0.0         30    4.6   0.0    2.5  2  DUF302    Domain of unknown function DUF302


Domain annotation for each model (and alignments):
>> DUF302  Domain of unknown function DUF302
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0    0.0022        40      34      51 ..     602     619 ..     593     629 .. 0.84
   2 ?    4.6   0.0    0.0016        30      22      34 ..     678     690 ..     674     711 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.0022
                 CC-GGGGGG-SEEEEEEE CS
      DUF302  34 qadpeiglllPcrvvVye 51 
                 q +++ ++ lP +v+V+e
  EFC38584.1 602 QSQQKRAAVLPFKVLVTE 619
                 5568899**********9 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0016
                 EEE-HHHHHHHHC CS
      DUF302  22 gaCnPklatealq 34 
                 ++CnPk+a+e+ +
  EFC38584.1 678 IVCNPKIANELSN 690
                 79*******9866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (888 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       637  (0.035529); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.27s 00:00:01.02 Elapsed: 00:00:00.49
# Mc/sec: 5458.00
//
Query:       EFC38585.1  [L=181]
Description: hypothetical protein NAEGRDRAFT_60926 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-36  125.5   0.1    1.7e-36  125.3   0.1    1.0  1  Ras              Ras family
    6.4e-34  116.7   0.0      9e-34  116.3   0.0    1.2  1  Roc              Ras of Complex, Roc, domain of DAPkinase
    9.6e-11   41.4   0.0    1.2e-10   41.2   0.0    1.2  1  Arf              ADP-ribosylation factor family
    4.1e-06   26.9   0.0    5.9e-06   26.3   0.0    1.2  1  MMR_HSR1         50S ribosome-binding GTPase
    3.4e-05   23.5   0.0    0.00033   20.3   0.0    2.2  1  GTP_EFTU         Elongation factor Tu GTP binding domain
    4.9e-05   22.8   0.0      6e-05   22.5   0.0    1.1  1  Gtr1_RagA        Gtr1/RagA G protein conserved region
    0.00023   21.0   0.0      0.013   15.3   0.0    2.0  2  ATP_bind_1       Conserved hypothetical ATP binding protein
    0.00057   19.4   0.0    0.00093   18.7   0.0    1.4  1  SRPRB            Signal recognition particle receptor beta su
     0.0025   17.7   0.1        2.2    8.1   0.0    2.1  2  RsgA_GTPase      RsgA GTPase
     0.0096   15.2   0.0      0.014   14.6   0.0    1.2  1  Beta_elim_lyase  Beta-eliminating lyase
  ------ inclusion threshold ------
      0.016   14.6   0.0      0.036   13.5   0.0    1.5  1  TniB             Bacterial TniB protein
      0.069   13.5   0.0       0.16   12.4   0.0    1.9  1  AAA_16           AAA ATPase domain
       0.11   13.1   0.2       0.26   11.8   0.2    1.6  1  RusA             Endodeoxyribonuclease RusA


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  125.3   0.1   1.2e-39   1.7e-36       1     160 [.       7     161 ..       7     163 .. 0.95

  Alignments for each domain:
  == domain 1  score: 125.3 bits;  conditional E-value: 1.2e-39
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++l+GdsavGK+ l+ rf+ d F+e+++sT  v+ +  + ++dg+++ +e wDTAGqe+f++++++yy  a++++ v+d +++ +++n++kw++e+++
  EFC38585.1   7 KVILLGDSAVGKSKLVERFMIDGFREQQQSTFAVNIFPYKAKIDGEDCDVEFWDTAGQERFNNVHPSYYDRAHACIFVFD-DRQITYKNLEKWYNELQT 104
                 99******************************************************************************.8999************** PP

                 HSTTTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras 100 vaeenvpivLvGnKvDleekravsteegeelakelglkfletSAktnenveeafeellrei 160
                 + +  +p +++ nK+Dl+ +    t++  ++a++ +l+ + +SA + +nv +af+++l+ +
  EFC38585.1 105 YRK-GIPSIVICNKIDLNME---ATKTTFNFASKRELPLYYASAADGTNVVKAFTDALKLA 161
                 999.7************963...4666778*************************999865 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  116.3   0.0   6.5e-37     9e-34       1     120 []       7     120 ..       7     120 .. 0.94

  Alignments for each domain:
  == domain 1  score: 116.3 bits;  conditional E-value: 6.5e-37
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGH..HHHCHHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsr..ssenlke 97 
                 Kv+l+Gds+vGK++l++rf+ d f+e+++st++v+++  ++ ki+g       +++ +++WDtaGqerf+++hp+y+ +a+++i+v+d+r  +++nl++
  EFC38585.1   7 KVILLGDSAVGKSKLVERFMIDGFREQQQSTFAVNIFPYKA-KIDG-------EDCDVEFWDTAGQERFNNVHPSYYDRAHACIFVFDDRqiTYKNLEK 97 
                 9************************************9986.5665.......5799*******************************7734679**** PP

                 HHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  98 WlkelkkvagkspvilvgnkiDl 120
                 W++el+++++ +p i+++nkiDl
  EFC38585.1  98 WYNELQTYRKGIPSIVICNKIDL 120
                 *********************95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.2   0.0   8.5e-14   1.2e-10      12     134 ..       3     127 ..       1     155 [. 0.80

  Alignments for each domain:
  == domain 1  score: 41.2 bits;  conditional E-value: 8.5e-14
                 TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEE....EEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT..THHHHHHH CS
         Arf  12 kkelrilllGLDnaGKtTilkklkleelvt.tvPTigfnv....eeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre..Rleeakee 103
                 +k ++++llG  + GK+ ++++++ + + + ++ T   n+     ++  ++ ++++wD  Gqe+  ++  +Y+++ +a ifv D  + +   le+  +e
  EFC38585.1   3 NKVIKVILLGDSAVGKSKLVERFMIDGFREqQQSTFAVNIfpykAKIDGEDCDVEFWDTAGQERFNNVHPSYYDRAHACIFVFDDRQITykNLEKWYNE 101
                 7999******99************99987637789888874333566779*********************************9654321144444455 PP

                 HHHHCTSGCCTTSEEEEEEE-TTSTTSS-HH CS
         Arf 104 LkalleeeelkevallvlaNKqDlpealsee 134
                 L++       k ++ +v++NK+Dl+  ++++
  EFC38585.1 102 LQT-----YRKGIPSIVICNKIDLNMEATKT 127
                 443.....35699***********8776655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.0   4.3e-09   5.9e-06       1     114 []       7     117 ..       7     117 .. 0.72

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 4.3e-09
                 EEEEEESTTSSHHHHHHHHHTS..TEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETTTTCSHHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltge..kaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflaleeadlillvvdaseeklkpldeel 97 
                 +v+++G + vGKS L+ + + +  + + +++  + + + +++++ ++ ++e++Dt+G  e   + +++  ++ +  +a++ ++v+d ++ ++k+l++  
  EFC38585.1   7 KVILLGDSAVGKSKLVERFMIDgfREQQQSTFAVNIFPYKAKIDGEDCDVEFWDTAG-QE---RFNNVHPSYYD--RAHACIFVFDDRQITYKNLEKWY 99 
                 589***************9876445566666666667777777766689********.54...33367777774..79********6655565555444 PP

                 HHHHHH.TTSEEEEEEES CS
    MMR_HSR1  98 eellee.akkplilvlnk 114
                 +el++  +++p i+++nk
  EFC38585.1 100 NELQTYrKGIPSIVICNK 117
                 444322579999999998 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.0   2.4e-07   0.00033      41     142 ..      25     128 ..       6     170 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 2.4e-07
                 STHCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTBSTHHHHHHHHHHH..HTTTEEEEEEESCGSTHH CS
    GTP_EFTU  41 rvlDtlkeErergiTiksaaisleketkkylinliDtPGHvdFskevirglrvlDgavlvvdaveGvepqteevlrlal..kegvpiivfiNKmDrlka 137
                  ++D   e ++  + +++   + + +++++ + + Dt G + F++     +  ++ +++v+d ++    + e+  + ++  ++g+p iv++NK+D   +
  EFC38585.1  25 FMIDGFREQQQSTFAVNIFPYKAKIDGEDCDVEFWDTAGQERFNNVHPSYYDRAHACIFVFDDRQITYKNLEKWYNELQtyRKGIPSIVICNKIDLNME 123
                 34777777888888888777777778*****************9988888**************9999999998876550156788*********9866 PP

                 HHHHH CS
    GTP_EFTU 138 elkei 142
                   k +
  EFC38585.1 124 ATKTT 128
                 55544 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0   4.4e-08     6e-05       1     138 [.       7     135 ..       7     155 .. 0.85

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 4.4e-08
   Gtr1_RagA   1 kvLLmGksgsGKtsm.rsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletl 98 
                 kv+L+G s  GK+ + ++ + d +  ++  + ++ i   k ++   +  +++ wD  Gqe+f +        + + +  + i+VfD +    + + ++l
  EFC38585.1   7 KVILLGDSAVGKSKLvERFMIDGFREQQQSTFAVNIFPYKAKID-GEDCDVEFWDTAGQERFNNVH-----PSYYDRAHACIFVFDDR----QITYKNL 95 
                 89***********9725568899999999999999999999995.7889***********998774.....67788999*******88....6667788 PP

   Gtr1_RagA  99 keilealrqyspeakvfvlihKmDliqedereeifeerke 138
                 ++  ++l++y + +   v+ +K+Dl  e ++++   + k+
  EFC38585.1  96 EKWYNELQTYRKGIPSIVICNKIDLNMEATKTTFNFASKR 135
                 8889999999999999********9988887766555554 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.031        42       2      49 ..      11      53 ..      10      54 .. 0.76
   2 !   15.3   0.0   9.6e-06     0.013      96     181 ..      59     133 ..      51     163 .. 0.77

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.031
  ATP_bind_1  2 vGpaGsGKttfvga.lseilelrgrsvavvNLDPAaeelpYeaavdire 49
                +G   +GK+ +v++ +++ ++++++s   vN      ++pY+a++d ++
  EFC38585.1 11 LGDSAVGKSKLVERfMIDGFREQQQSTFAVN------IFPYKAKIDGED 53
                588899*****99834577777777777777......599999999776 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 9.6e-06
  ATP_bind_1  96 fDtPGQielfthseslakiveeLesefalvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkeklekeleffe 181
                  Dt GQ ++ ++++s          + a  +++++D + +t   k +++  +    ++r ++P +v++nk+Dl  e ++  ++f +
  EFC38585.1  59 WDTAGQERFNNVHPSYY--------DRAHACIFVFDDRQITY--KNLEK-WYNELQTYRKGIPSIVICNKIDLNMEATKTTFNFAS 133
                 6999***********99........88888999999998887..55555.5555899****************7766666665554 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.0   6.7e-07   0.00093       5     133 ..       7     129 ..       3     166 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 6.7e-07
                 EEEEE-STTSSHHHHHHHHHHSS---B---S..S-EEETTG....GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEET.TS-HHHHHHHHHHH CS
       SRPRB   5 avllvGlsdsGKTslftrLttdsvkktvtSq..essaalkv.ksekgskltliDfPGheklrqklleklkaksslkglvfvvDS.tidpkevkevAEll 99 
                 +v+l+G s  GK  l +r + d +++ + S    + + +k   + ++  +++ D  G+e++ +       + +++++ +fv D   i  k++++     
  EFC38585.1   7 KVILLGDSAVGKSKLVERFMIDGFREQQQSTfaVNIFPYKAkIDGEDCDVEFWDTAGQERFNNVHPS---YYDRAHACIFVFDDrQITYKNLEK----W 98 
                 79********************999999998756677777733568999***********9865444...578899*****9852566666644....4 PP

                 HHHHHHHHHHTT---EEEEEE-TTSTT---HHHH CS
       SRPRB 100 yeilliteklkdavdiliACnKqelflakspkli 133
                 y+ l   ++ +++++ ++ CnK +l +  +++  
  EFC38585.1  99 YNEL---QTYRKGIPSIVICNKIDLNMEATKTTF 129
                 5433...444678888889*****9997776665 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.1   0.0    0.0016       2.2     102     120 ..       8      26 ..       2      41 .. 0.80
   2 !    7.7   0.0    0.0022         3      27      89 ..      87     149 ..      74     162 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0016
                  EEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase 102 svlvGqSGvGKStLinall 120
                  ++l+G S vGKS L+++++
   EFC38585.1   8 VILLGDSAVGKSKLVERFM 26 
                  689************9865 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0022
                  TTT--HHHHHHHHHH..HHHTT-EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTTHTT CS
  RsgA_GTPase  27 epelslnlldrfLvl..aeekgiepvivlnKiDlleeeeeleelkeelealgyevllvsaktkeg 89 
                  + +++ + l++   +    +kgi+ +++ nKiDl  e++  +++ +  ++ ++++++ sa ++++
   EFC38585.1  87 DRQITYKNLEKWYNElqTYRKGIPSIVICNKIDLNMEAT--KTTFNFASKRELPLYYASAADGTN 149
                  55556666666554400456899***********99998..667777777777888888776654 PP

>> Beta_elim_lyase  Beta-eliminating lyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0     1e-05     0.014      63     166 ..      37     141 ..      17     165 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1e-05
                      HHHHH--TTEEEEEETT-HHHHSSTTHHHHCC--EEEEE-EBTT.......TBE-HHHHHHHS--S-TTS-EEEEEEEESSBTTTTTB---HHH CS
  Beta_elim_lyase  63 llkillqrgeevivtepahihfdetgaiaelagvklrdlknkea.......GkmdlekleaaikevgaheekiklisltvTnntagGqvvslee 149
                       +++ + +++++i +e++ ++f+ t + + ++ v++   + ++a        +++ ++le+  +e + +++ i+ i++ + +       + +e 
       EFC38585.1  37 TFAVNIFPYKAKIDGEDCDVEFWDTAGQERFNNVHPSYYDRAHAcifvfddRQITYKNLEKWYNELQTYRKGIPSIVICNKID------LNMEA 124
                      56777789999***************************************99*************888**********99999......6**** PP

                      HHHHHHHHHHCT-EEEE CS
  Beta_elim_lyase 150 lrevaaiakkygiplhl 166
                       + + ++a k+++pl +
       EFC38585.1 125 TKTTFNFASKRELPLYY 141
                      *************9975 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   2.6e-05     0.036      37      67 ..       7      37 ..       2      51 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.6e-05
        TniB 37 nlllvGdsnnGKtmivekFarlhppekdeda 67
                +++l+Gds++GK+++ve+F+ +  +e+++++
  EFC38585.1  7 KVILLGDSAVGKSKLVERFMIDGFREQQQST 37
                6899***************988766655544 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   0.00011      0.16      27      45 ..       8      26 ..       7     163 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00011
      AAA_16 27 vllsGesGvGKsslvrell 45
                v+l G+s+vGKs+lv++++
  EFC38585.1  8 VILLGDSAVGKSKLVERFM 26
                789************9997 PP

>> RusA  Endodeoxyribonuclease RusA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   0.00019      0.26      17      94 ..      80     159 ..      61     167 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00019
                 S.SEEE-HHHHHHHHHHHHHHHHTT-..TT-B-S-EEEEEEEE-SS.................SS---HHHHHHHHHHHHH CS
        RusA  17 g.rtytpkktkayeeevkaylekqyekdkeplegplkvevtlyfpipksl..skkkkqealektkkpDiDNlaKavlDaln 94 
                    ++ +++  +y++  k+y e q   +k   +  +  +++l ++++k++    +k++  l  ++  D  N++Ka  Dal+
  EFC38585.1  80 AcIFVFDDRQITYKNLEKWYNELQTY-RKGIPSIVICNKIDLNMEATKTTfnFASKRELPLYYASAADGTNVVKAFTDALK 159
                 25667777788999999998888884.555555566689999999999885434444455555****************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (181 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       588  (0.032796); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1044.76
//
Query:       EFC38586.1  [L=523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-20   73.2   0.0    2.7e-09   37.0   0.0    2.6  2  DEAD            DEAD/DEAH box helicase
    5.7e-05   23.4   0.1    0.00035   20.9   0.1    2.4  2  Helicase_C      Helicase conserved C-terminal domain
  ------ inclusion threshold ------
       0.12   11.1   0.0       0.34    9.6   0.0    1.7  2  Oxidored_nitro  Nitrogenase component 1 type Oxidoreductase


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.5   0.0   5.4e-12   3.2e-08       3      74 ..      55     134 ..      53     169 .. 0.84
   2 !   37.0   0.0   4.6e-13   2.7e-09      72     155 ..     183     265 ..     162     277 .. 0.84

  Alignments for each domain:
  == domain 1  score: 33.5 bits;  conditional E-value: 5.4e-12
                 HHHHHHHHHH..TTCEEEEEESTTSSHHHHHHHHHHHHHHHS......TTSTS-EEEEEESSHHHHHHHHHHHHHHTTTS CS
                 xxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   3 iQaeaiplil..gggdvlvaaeTGsGKTlaflipvlqivyet......kgktgpkalivePtreLaeqtlnnlkkfkkyi 74 
                  Q+++++ +   + +dv+++a+  sGKTla+l+p ++ v++        +++g +aliv+Ptre a  +  ++ k+++ +
  EFC38586.1  55 LQSKTLEVVSkdNSKDVFIEAPIFSGKTLAYLVPTFELVSQAikserwAERPGFRALIVVPTREAAIAVGFQIDKYISSL 134
                 688899999865669*********************99988899999989**************9999988888888764 PP

  == domain 2  score: 37.0 bits;  conditional E-value: 4.6e-13
                 TTSTSEEEEEETTSSHHHHHHHHHTT.CSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  72 kyidlrvlliiggvaardqlskldng.vdivvgtpgrlddllstgklnlsqvrflVlDEadrlldqgfsdfinrilnqlpqitcd 155
                 + ++l++ +i gg++ +++++ ld++ ++i+v+tpgrl+d++++    +++++++V+D ++ +  +  +  ++++++++pq+t++
  EFC38586.1 183 NVYGLSYAVICGGKSMEQEITMLDASePEIIVATPGRLLDHMKNSD-YFRNCKIVVVDDCQLFKGD-VEGVMDKVFENIPQTTQR 265
                 335699999**************9555*************995444.4**************9998.9***********988765 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.42   2.5e+03      55      55 ..     139     139 ..      95     216 .. 0.58
   2 !   20.9   0.1   5.8e-08   0.00035       3     108 ..     312     413 ..     310     416 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.42
                 H CS
  Helicase_C  55 r 55 
                 r
  EFC38586.1 139 R 139
                 2 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 5.8e-08
                 HHHHHHHHHHTTTTSEEEEEESSHHHHHHHHHHHHHTTSTEEEESTTSTHHHHHHHHHHHHTTSSSEEEESGGGTSSSTSTTESEEEESSSSSSHHHHH CS
  Helicase_C   3 leallellkleeeggkilifvntidrlekvklllekkgikvavlhgelpqnereeileqfnkgesdvLiatdvaerGidipkvnlVinfdlprnvtsyi 101
                 l+ l ++l ++++++k+ +f ++ + ++ +++l  ++gi ++ + +++  +  + ++++fn+++  +  ++++a +    p+v+lVi++++p++ ++y 
  EFC38586.1 312 LKVLHQIL-SQNKHKKVAVFGENSQIIH-THYLMAENGIFSLLIASKIAPSRSLTSFSNFNQQQNGIAFCSNIACQ--MTPDVDLVIHLGAPETQEKYE 406
                 56788888.899*************885.89999999***********************999988*******988..579****************** PP

                 HHHTTSS CS
  Helicase_C 102 qriGRtg 108
                  r  Rt+
  EFC38586.1 407 SRLSRTY 413
                 *****96 PP

>> Oxidored_nitro  Nitrogenase component 1 type Oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.19   1.1e+03     242     278 ..     204     238 ..     191     242 .. 0.75
   2 ?    9.6   0.0   5.6e-05      0.34     249     306 ..     299     358 ..     282     430 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.19
                     HHTCHHHHHHHHHHHHHHHHHHHHHHHHHTT-EEEEE CS
  Oxidored_nitro 242 llgkevaperiaeerarlldaladyheylagkrvaiy 278
                     +l++++ pe i +  +rlld++++  +y+++ +++++
      EFC38586.1 204 MLDASE-PEIIVATPGRLLDHMKN-SDYFRNCKIVVV 238
                     455555.66677767999999999.889999998886 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 5.6e-05
                     HHHHHHHH..HHHHHHHHHHHHHHTT-EEEEECSSHHHHHHHHHHHHHT-EEEEEEESSS CS
  Oxidored_nitro 249 periaeer..arlldaladyheylagkrvaiygdpdrvvalarllkelGmevvaagteta 306
                     +++i++ +  a+ l+ l ++ ++ + k+va++g+ ++ ++   l++e G+   +++++ a
      EFC38586.1 299 KQSIIKTQntAESLKVLHQILSQNKHKKVAVFGENSQIIHTHYLMAENGIFSLLIASKIA 358
                     55555533246666777777788889***********************98877777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1089  (0.0607396); expected 358.6 (0.02)
Passed bias filter:                      640  (0.0356964); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 2970.40
//
Query:       EFC38587.1  [L=416]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     8e-109  363.6   5.3   1.1e-108  363.2   5.3    1.1  1  tRNA-synt_1e  tRNA synthetases class I (C) catalytic domain
    5.7e-20   71.4   2.7    5.5e-12   45.1   0.9    2.1  2  tRNA-synt_1g  tRNA synthetases class I (M)
     0.0015   16.9   0.0     0.0056   15.0   0.0    1.9  2  tRNA-synt_1   tRNA synthetases class I (I, L, M and V)
  ------ inclusion threshold ------
      0.063   13.7   0.1        0.3   11.6   0.1    2.1  1  Terminase_4   Phage terminase, small subunit


Domain annotation for each model (and alignments):
>> tRNA-synt_1e  tRNA synthetases class I (C) catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  363.2   5.3  2.5e-112  1.1e-108      10     299 ..      78     385 ..      70     387 .. 0.93

  Alignments for each domain:
  == domain 1  score: 363.2 bits;  conditional E-value: 2.5e-112
                   EEEEEEEEBTTS--BHHHHHHHHHHHHHHHHHHH.TT-EEEEEEEBB--SHHHHHHHHHTTS-HHHHHHHHHHHHHHHHHHTT----SB--BGGGGH CS
  tRNA-synt_1e  10 vtlYvCGptvydashlGhaRslvafDilrrilqa.lgYdvqfvqnvtDidDkiikrareeeksvkelaekfieefkkdleaLnvlkptleprvsekv 105
                   +++Y+CGptvyd++hlGhaR++v++Di+ ril + ++Y v +v  +tD+dDki+kra+e +k+ +e++ k++ +f +d+++Lnv +p + +rv+e++
    EFC38587.1  78 INWYSCGPTVYDDTHLGHARNYVCLDIIYRILAHyFNYPVLHVMGITDVDDKILKRAAELGKQPSEISRKYEFDFIEDMKKLNVIQPYVYTRVTEHI 174
                   89******************************988************************************************************** PP

                   HHHHHHHHHHHHTTSEEE-TTS-EEE-GGG-....TTTTTTTT--HHHHHHT----S--S-SSTT-EEEEEE--TTS--B--TTSSEEE-SSHHHHH CS
  tRNA-synt_1e 106 deiielvekliekgyaYavsdgdvyfdvskk....eeYgklskqnleelelgaegevseekkdkkDfaLWkaskegepswdsPwgkGRPGWhieCsv 198
                   +ei ++ve++ ++g+ Y++ +g vyfd +k+    + Ygkls++n +e  +++++e  eekkd++DfaLWk +  +   w+s wg GRPGWhieCs+
    EFC38587.1 175 EEIKQFVEEMEKNGFTYTTANGGVYFDSKKFeqndHYYGKLSPNNAQESIQQEHIEHREEKKDPRDFALWKFTSRDYLGWESKWGYGRPGWHIECSA 271
                   **************************98765111167********9999999999999*************************************** PP

                   HHHHHH-.....SSEEEEEEEGGGTTTHHHHHHHHHHHHS........SS--EEEEEEE--EEETTBE--TTTT---BHHHHHTTS-HHHHHHHHHS CS
  tRNA-synt_1e 199 maskllg.....seidihsGGiDLafPhhenelaqseaaf........dkqlvkyflhnghlkiegekmsksLknfitikdvlkkfdprqlRlllls 282
                   m++++++      +idihsGGiDLafPhh+ne+aqsea+         ++++ +yf+h ghl+i+g kmsksLknfitikd+lk+++p q+R++ l 
    EFC38587.1 272 MIDHIFNnksgaATIDIHSGGIDLAFPHHNNEIAQSEAKNhahfccsrETNWCNYFIHVGHLHIKGLKMSKSLKNFITIKDFLKRYSPDQFRIFCLL 368
                   *****986666678**********************9764222222225789********************************************* PP

                   S-TTS-EEE-HHHHHHH CS
  tRNA-synt_1e 283 ahyrsqldfkeelleea 299
                   ++y+++ld++e+++ ea
    EFC38587.1 369 HQYNQTLDYNEDAIGEA 385
                   ************99876 PP

>> tRNA-synt_1g  tRNA synthetases class I (M)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.1   0.9   1.2e-15   5.5e-12      12     163 ..      89     240 ..      82     245 .. 0.92
   2 !   26.0   0.0   8.1e-10   3.7e-06     315     369 ..     327     380 ..     312     401 .. 0.74

  Alignments for each domain:
  == domain 1  score: 45.1 bits;  conditional E-value: 1.2e-15
                   S---HHHHHHHHHHHHHHHHHHHT.T-EEEEEEEE---SHHHHHHHHHTTS-HHHHHHHHHHHHHHHHHHTT---SEEEETTSHHHHHHHHHHHHHH CS
  tRNA-synt_1g  12 gklHlGhllevisaDifaRykrlr.geevlfvcgtDehGtpielkAekegvtpeelvekvheeikelfkklnisfdkygrttseehkelvqeifkkl 107
                   +++HlGh+++++  Di++R      ++ vl+v g      +i  +A++ g +p+e+ +k++  + e++kkln+    y  t  +eh e  +++++++
    EFC38587.1  89 DDTHLGHARNYVCLDIIYRILAHYfNYPVLHVMGITDVDDKILKRAAELGKQPSEISRKYEFDFIEDMKKLNVI-QPYVYTRVTEHIEEIKQFVEEM 184
                   679****************976554999******99999*********************************96.579999999************* PP

                   HHTT-EEEEEEEEEEETTTTEEE-GGG-EE........-TTS-EE-TTSSB-E... CS
  tRNA-synt_1g 108 kekgliyekeieqlycpkderflpdryvegtCPkckseeargdqceecgkklepte 163
                   +++g+ y+++  ++y  +++   +d y     P+  +e+ + +++e+  +k +p +
    EFC38587.1 185 EKNGFTYTTANGGVYFDSKKFEQNDHYYGKLSPNNAQESIQQEHIEHREEKKDPRD 240
                   ***************************99999*99999999999999999888877 PP

  == domain 2  score: 26.0 bits;  conditional E-value: 8.1e-10
                   EEEE--EEE--------------HHHHHHHH-HHHHHHHHHH.HS-TTS-EEE-HH CS
  tRNA-synt_1g 315 vvaheyltvegkKlSkSrgvvvkakealerldadllRYylaa.eapekkDldfswe 369
                    +  ++l ++g K+SkS ++++++k++l+r+++d++R + +  + +++  ld++++
    EFC38587.1 327 FIHVGHLHIKGLKMSKSLKNFITIKDFLKRYSPDQFRIFCLLhQYNQT--LDYNED 380
                   56679********************************77665244444..444444 PP

>> tRNA-synt_1  tRNA synthetases class I (I, L, M and V)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.11   4.9e+02      32      55 ..      85     108 ..      79     125 .. 0.81
   2 !   15.0   0.0   1.2e-06    0.0056     559     597 ..     335     373 ..     285     378 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.11
  tRNA-synt_1  32 PyvtGslHiGhalaktlkdiviry 55 
                  P v    H+Gha + +  di+ r+
   EFC38587.1  85 PTVYDDTHLGHARNYVCLDIIYRI 108
                  6777789**************996 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.2e-06
  tRNA-synt_1 559 eeGrKmSKslgNvidpldvikkygadalRltlilsdvgr 597
                   +G KmSKsl+N i  +d +k+y+ d  R + +l ++ +
   EFC38587.1 335 IKGLKMSKSLKNFITIKDFLKRYSPDQFRIFCLLHQYNQ 373
                  5899*************************9988777765 PP

>> Terminase_4  Phage terminase, small subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   6.6e-05       0.3      13      58 ..     154     205 ..     115     230 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 6.6e-05
  Terminase_4  13 delgilseldseaLaayceayaryreaekkiekeGvtittaegeg......a 58 
                  ++++ l+ +  ++  +  e +++++++ +++ek+G+t+tta+g         
   EFC38587.1 154 EDMKKLNVIQPYVYTRVTEHIEEIKQFVEEMEKNGFTYTTANGGVyfdskkF 205
                  55666777888888999999*********************99546665543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1016  (0.056668); expected 358.6 (0.02)
Passed bias filter:                      655  (0.036533); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.37s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 2332.43
//
Query:       EFC38588.1  [L=507]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-73  247.7   1.1    1.3e-73  247.7   1.1    1.8  2  IF-2B       Initiation factor 2 subunit family
     0.0042   15.9   0.1      0.008   14.9   0.1    1.4  1  CdhD        CO dehydrogenase/acetyl-CoA synthase delta subuni
  ------ inclusion threshold ------
       0.36   10.9   7.0       0.79    9.8   6.1    1.9  2  DUF3759     Protein of unknown function (DUF3759)
       0.88    8.9  18.4        1.5    8.1  18.4    1.3  1  FAM76       FAM76 protein


Domain annotation for each model (and alignments):
>> IF-2B  Initiation factor 2 subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.3      0.86   3.9e+03      63      95 ..      88     120 ..      49     129 .. 0.69
   2 !  247.7   1.1   2.9e-77   1.3e-73       1     282 []     169     493 ..     169     493 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.86
                 HHCCTTTSSHHHHHHHHHHHHHHHHHHHHHHHH CS
       IF-2B  63 iselksssdvkeakksliekikelikeieeade 95 
                  ++ + s+++++ +++l e+ ++l ke ++ d+
  EFC38588.1  88 STNPTTSQQTNASDQRLREENERLKKELLQRDK 120
                 344556666777777777777777777766665 PP

  == domain 2  score: 247.7 bits;  conditional E-value: 2.9e-77
                 SS-SHHHHHHHHHHHHHHHHHHCCCSTHHHH....HHHHHHHHHHHHTSSTS-HHHHHHHHHHHH...HHHCCTTTSSHHHHHHHHHHHHHHHHHH.HH CS
       IF-2B   1 kvrGspaiaiaalevllevikdaktskvaeL....keelrkaidlLkkarPtavslgnairrllk...eiselksssdvkeakksliekikelike.ie 91 
                 ++ G +a+ +a+  vl++ ++d + ++ +++       +++ id Lk++rP++v + na+rr++    +i + +   + ++ k++l e+++++i+e i 
  EFC38588.1 169 QITGCNARTLAMFTVLKQLVNDTEIPEDKQFsrclDPLVSSVIDHLKQCRPMSVGMKNALRRFKYclhQIDKESYIRTHQQRKEALSEYVDRYIEErIS 267
                 67899**************************8888888999***********************966566666666788899999***********999 PP

                 HHHHHHHHHHHTTC-TTEEEEEES--SHHHHHHHHHHHTTEEEEEEEEEXTTTTHHHTHHHHHHHTTXEEEEEEGGGHHHHHHCTESEEEEEXSEEETT CS
       IF-2B  92 eadekigdiaaelikdgdtilTicnsktvlevlraaakekkkfkVivvEsrPrlqGrltakeLvqagipvtlitdsavayvmseevdkvivGAdrilen 190
                   ++ i++ + + ikdgdtilT++ s+++ +++++aa+ +kk++Vivv+srP+++G++++k L++ag+ + +++ +av yvm+  v+kv++GA++il+n
  EFC38588.1 268 VPEKEIVKKGVNGIKDGDTILTYALSEVLEKMIIEAAQ-SKKISVIVVDSRPKNEGKELVKRLTRAGVKCSIVLVNAVTYVMKD-VSKVFLGANSILSN 364
                 99*********************************998.579******************************************.************** PP

                 SEEEEETTHHHHHHHHHHTTXEEEEEXXGGGBESTSSSGGGSSXXBEXTHHHHEETTEESSTT.................................... CS
       IF-2B 191 GaiankiGTsslAvlAkefnipvlvvaeslkfservqldedifieerdpeellnitgeriaee.................................... 253
                 G +++++GT+ +A+ Ak+fnipv v++e++kfs   qld+ + +e++dp +l+  + +  +++                                    
  EFC38588.1 365 GNVYSRVGTAVVAMTAKAFNIPVVVCCETYKFSAHSQLDSITTNELGDPYDLVDLSTTPQRHHtvnylssneigqlevegvtkfddketvynmenfesi 463
                 ******************************************************9998876669*********************************** PP

                 .TEEEEEBSEEEEEGGGXSEEEETTEEEXC CS
       IF-2B 254 .elkvvnpafDvtPpelItliITevGvlpp 282
                  +l++vn+++D+tP ++++++++e+G++pp
  EFC38588.1 464 pNLHIVNLTYDLTPCHYVDMVLCEFGAIPP 493
                 ****************************98 PP

>> CdhD  CO dehydrogenase/acetyl-CoA synthase delta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1   1.8e-06     0.008     107     175 ..     270     340 ..     255     355 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.8e-06
                 SHHHHHHHHTTTCCC--EEEEE-TTTHHH.HHHHHHHTT--EEEE-.SSHHHHHHHHHHHHCTT-.--EEE CS
        CdhD 107 dpevlkaalevvederpllyaAtkddyke.iaelaleykvpvvllsindleelkelarkllkagv.kdivl 175
                 + e++k++++ ++d   +l  A  + +++ i+e+a + k  v+++ +   +e kel+++l++agv  +ivl
  EFC38588.1 270 EKEIVKKGVNGIKDGDTILTYALSEVLEKmIIEAAQSKKISVIVVDSRPKNEGKELVKRLTRAGVkCSIVL 340
                 57999********99999988888877661579********************************668887 PP

>> DUF3759  Protein of unknown function (DUF3759)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   6.1   0.00018      0.79      31      83 ..      21      74 ..      17      81 .. 0.86
   2 ?   -1.9   0.0      0.79   3.5e+03      43      55 ..     245     257 ..     232     267 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00018
     DUF3759 31 ayedhqrkeGkpvshafaKellAgfagaevdklvetkgldeid.rekakreAke 83
                a e+++++e k+++ ++aKe   g+  +e  kl+et   ++ + r kak+eA++
  EFC38588.1 21 ADEKKKQREAKKMEKKQAKEQKGGLSKEERKKLFETNENNKRQeRLKAKEEAEN 74
                568999******************************988765538899999986 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.79
     DUF3759  43 vshafaKellAgf 55 
                  +h++ Ke+l+ +
  EFC38588.1 245 RTHQQRKEALSEY 257
                 4678888877654 PP

>> FAM76  FAM76 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1  18.4   0.00034       1.5     136     253 ..      23     133 ..      10     157 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00034
       FAM76 136 akakeeeeekrskskkkkskskkskkskekskekkaskkkskkhkkrssrlevskleeeklaeekes.netskksldsnssdhlvavtqLkeeiaslkk 233
                 +k+k++e++k +k++ k++k   sk++++k  e+++++k++++ k +++  +++  +   + ++ ++ +++ ++s ++n sd     ++L+ee ++lkk
  EFC38588.1  23 EKKKQREAKKMEKKQAKEQKGGLSKEERKKLFETNENNKRQERLKAKEEAENITTPT---MPSNVTNnSTNPTTSQQTNASD-----QRLREENERLKK 113
                 333333333333333333333334444444333333333333333333333333333...2122111012222244444444.....58********** PP

       FAM76 234 qleqkdqellekdkkitelk 253
                 +l q+d+  l+ +kk  e +
  EFC38588.1 114 ELLQRDKLYLDLKKKYQENR 133
                 **********9999987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2663  (0.14853); expected 358.6 (0.02)
Passed bias filter:                      748  (0.0417201); expected 358.6 (0.02)
Passed Vit filter:                       116  (0.00646996); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.78u 0.33s 00:00:01.11 Elapsed: 00:00:00.50
# Mc/sec: 3024.93
//
Query:       EFC38589.1  [L=385]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       723  (0.0403257); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.24s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 2840.89
//
Query:       EFC38590.1  [L=1061]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0002   21.4  14.0     0.0002   21.4  14.0    3.2  3  Ax_dynein_light  Axonemal dynein light chain
  ------ inclusion threshold ------
       0.49   10.5   2.6          1    9.4   0.7    2.6  2  Tubulin-binding  Tau and MAP protein, tubulin-binding repeat
        1.3    8.4   6.2          3    7.1   6.2    1.6  1  DUF4407          Domain of unknown function (DUF4407)
        6.8    7.4  12.8       0.37   11.5   4.1    3.3  3  DUF2203          Uncharacterized conserved protein (DUF2203)


Domain annotation for each model (and alignments):
>> Ax_dynein_light  Axonemal dynein light chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   1.7      0.38   1.7e+03     144     180 ..     238     274 ..     224     322 .. 0.70
   2 !   21.4  14.0   4.5e-08    0.0002      23     179 ..     434     593 ..     419     599 .. 0.82
   3 ?   -2.8   0.1       1.1     5e+03     150     180 ..     837     870 ..     805     873 .. 0.62

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.38
  Ax_dynein_light 144 elkaklealekrekerrqeeekkheeeieflkksnqq 180
                      e+k+ +e++ k  k+ +++  +  +++++f+k++++ 
       EFC38590.1 238 ETKQIMEEEIKTMKNMKKKVPSIATQQLDFFKRKSRD 274
                      4444555555555555555555566666666655544 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 4.5e-08
  Ax_dynein_light  23 qvssepatredviklqekldeklqqrqar.etGiCpiReel..ysqcfdEliRQvtincaerGllLlrvrdelrmtiaayktlyessvaFgmrk 113
                        s++p++r +v++l   ++++l++ + + +    ++ ee+  +  +  E+ RQ++ +caerG+lL ++  +++  +++  ++ +++   ++  
       EFC38590.1 434 FPSNKPTSRIEVVQLARTFEQMLSELKEKkKDEASEVNEEItiLDVIASEISRQISGQCAERGILLDKLVSRFKRLTSKSTKISKEAA-SKLED 526
                      5699*******************97655505567999998621455666**************************9999999888666.56666 PP

  Ax_dynein_light 114 alqaeqgkselekkikeL.eeekeelekqvaelkaklealekrekerrqeeekkheeeieflkksnq 179
                         +e++ + + +  ++L ++++++l k+ +e+ + l+++e+ +++ rq+++  h+   e++++  +
       EFC38590.1 527 IQAREKQVNSMVDFYTDLaKSKEDQLAKKEEEIIELLDQIERLKSQLRQTKKGIHAMTSEYFQERIR 593
                      6678888888888889994667779*******************************99999987655 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 1.1
  Ax_dynein_light 150 ealekrek...errqeeekkheeeieflkksnqq 180
                      e ++kr     + + e ++ +++ i+flk + + 
       EFC38590.1 837 EVIKKRIDsnvNSQPESRNSKRDSIDFLKYKMKL 870
                      3344433300033444556667778888877665 PP

>> Tubulin-binding  Tau and MAP protein, tubulin-binding repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.63   2.8e+03       3      15 ..     260     272 ..     259     273 .. 0.77
   2 ?    9.4   0.7   0.00023         1       6      20 ..     286     300 ..     285     304 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.63
  Tubulin-binding   3 IeskKldfskvqS 15 
                      I ++ ldf k +S
       EFC38590.1 260 IATQQLDFFKRKS 272
                      99*****766666 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00023
  Tubulin-binding   6 kKldfskvqSKvGSl 20 
                      kK ++s+v+SKv+S+
       EFC38590.1 286 KKKNYSQVKSKVNSM 300
                      799***********8 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   6.2   0.00066         3     127     239 ..     448     579 ..     414     598 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00066
     DUF4407 127 laaaltaelaeleaqiaalqaeidaaearldalraeaqkeldgtk.................gtgttgvaGkgpaakekkaqldaaqaelaelkakld. 207
                 la ++++ l+el+++ ++  +e+++  + ld    e  ++++g++                 +          ++ ke+ ++l+++qa+ +++++ +d 
  EFC38590.1 448 LARTFEQMLSELKEKKKDEASEVNEEITILDVIASEISRQISGQCaergilldklvsrfkrlT------SKSTKISKEAASKLEDIQAREKQVNSMVDf 540
                 444577777777777777777777777777777777777777777777777766665543222......233456666777777777777777777777 PP

     DUF4407 208 .......atarlaalraelaeleaerakeraasqaaaaa 239
                        ++++la++++e+ el +++++ +++ ++++++
  EFC38590.1 541 ytdlaksKEDQLAKKEEEIIELLDQIERLKSQLRQTKKG 579
                 778888878888888888888888888888777776554 PP

>> DUF2203  Uncharacterized conserved protein (DUF2203)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       1.4   6.2e+03      60      86 ..     241     267 ..     225     300 .. 0.66
   2 ?   -0.7   0.2      0.49   2.2e+03      22      64 ..     445     483 ..     438     498 .. 0.57
   3 ?   11.5   4.1   8.3e-05      0.37      10      90 ..     501     587 ..     493     593 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.4
     DUF2203  60 aeieelveeieelGvevkdleaglvDF 86 
                 + +ee ++++++++ +v +++   +DF
  EFC38590.1 241 QIMEEEIKTMKNMKKKVPSIATQQLDF 267
                 334455555555555555555555555 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.49
     DUF2203  22 lralrkeleeleeeleeakaeaekseaaeleaeleeleaeiee 64 
                 +++l++ +e++ +el+e+k+++    a+e ++e++ l+  ++e
  EFC38590.1 445 VVQLARTFEQMLSELKEKKKDE----ASEVNEEITILDVIASE 483
                 5566666666666666666654....33444444333333333 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 8.3e-05
     DUF2203  10 alLpllkelleelralrkeleeleeeleeakaeaekse......aaeleaeleeleaeieelveeieelGvevkdleaglvDFpakl 90 
                 +l+ + k+l+++  +  ke++++ e++++ +++ ++        a+++e +l++ e+ei el+++ie+l+ ++++ ++g+    +++
  EFC38590.1 501 KLVSRFKRLTSKSTKISKEAASKLEDIQAREKQVNSMVdfytdlAKSKEDQLAKKEEEIIELLDQIERLKSQLRQTKKGIHAMTSEY 587
                 566677777777777888888877777777777665549999*999*****************************999987766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1061 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2384  (0.132969); expected 358.6 (0.02)
Passed bias filter:                      559  (0.0311785); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.04u 0.34s 00:00:01.38 Elapsed: 00:00:00.58
# Mc/sec: 5494.20
//
Query:       EFC38591.1  [L=679]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.098   13.1   3.3          1    9.8   0.1    3.3  3  IATP      Mitochondrial ATPase inhibitor, IATP
        3.8    5.3   8.7       0.15   10.0   1.6    2.0  2  Prominin  Prominin


Domain annotation for each model (and alignments):
>> IATP  Mitochondrial ATPase inhibitor, IATP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.14   1.2e+03      35      46 ..     192     203 ..     167     216 .. 0.69
   2 ?    1.3   0.1      0.05   4.5e+02      59      91 ..     376     408 ..     348     414 .. 0.80
   3 ?    9.8   0.1   0.00012         1      62      97 ..     629     664 ..     564     665 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.14
        IATP  35 apkgtGggGsir 46 
                 ++ gtGggG ir
  EFC38591.1 192 SGGGTGGGGKIR 203
                 455677777875 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.05
        IATP  59 sEeeyirqrekekLaeLkeklaeqkeHleelee 91 
                 +Ee+ ir     + ++Lk kl++ ++  + +++
  EFC38591.1 376 EEEQHIRSISVTHSLSLKSKLNKLQKEVQTVSQ 408
                 689999999999999999999999888887765 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00012
        IATP  62 eyirqrekekLaeLkeklaeqkeHleeleeHieait 97 
                   ++q +k++L++Lkek + +++  e+l e + +i+
  EFC38591.1 629 LTLKQLKKQRLQQLKEKKETEERMMESLMEEQSEIN 664
                 5789*****************999999999888885 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   1.6   1.6e-05      0.15     633     694 ..     338     417 ..     282     443 .. 0.75
   2 ?   -1.4   0.9     0.045   4.1e+02     653     698 ..     626     671 ..     586     674 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 1.6e-05
    Prominin 633 leelanelsngk..................knlkqslkneaqdlraiqqelvlplessvkklkksvkkldeensdlqesi 694
                   +l +++++ +                  ++l+q++ +e q++r+i  +  l l+s+++kl+k+v+++++ n++++e  
  EFC38591.1 338 SVDLRTSQKSDTvrsstgkriplskrygtvTDLNQAIMEEEQHIRSISVTHSLSLKSKLNKLQKEVQTVSQLNHSMNEDA 417
                 33333333333333344667788888888899***************************************999988754 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.045
    Prominin 653 neaqdlraiqqelvlplessvkklkksvkkldeensdlqesikkll 698
                 ++  +l+++++++ ++l+++ ++ ++ +++l ee+s++++ +k + 
  EFC38591.1 626 KAPLTLKQLKKQRLQQLKEKKETEERMMESLMEEQSEINNYLKAIY 671
                 4556788888888888888888888888888888888888777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (679 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2046  (0.114117); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.81u 0.39s 00:00:01.20 Elapsed: 00:00:00.57
# Mc/sec: 3567.58
//
Query:       EFC38592.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       661  (0.0368676); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.35s 00:00:00.96 Elapsed: 00:00:00.56
# Mc/sec: 1685.81
//
Query:       EFC38593.1  [L=412]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-77  259.5   2.1    7.3e-47  160.1   0.1    3.2  2  GCD14            tRNA methyltransferase complex GCD14 subunit
    3.4e-06   27.0   0.0    5.3e-06   26.3   0.0    1.3  1  PCMT             Protein-L-isoaspartate(D-aspartate) O-methyl
    7.5e-06   25.8   0.0    1.7e-05   24.6   0.0    1.6  1  Methyltransf_31  Methyltransferase domain
     0.0087   15.5   0.3      0.031   13.7   0.0    2.1  3  Methyltransf_4   Putative methyltransferase
  ------ inclusion threshold ------
      0.017   15.8   0.0      0.072   13.8   0.0    2.1  2  Methyltransf_25  Methyltransferase domain
      0.024   14.5   0.0      0.047   13.5   0.0    1.5  1  GCD14_N          tRNA methyltransferase complex GCD14 subunit
       0.11   12.2   0.0        3.3    7.3   0.0    2.6  3  Methyltr_RsmB-F  16S rRNA methyltransferase RsmB/F


Domain annotation for each model (and alignments):
>> GCD14  tRNA methyltransferase complex GCD14 subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  160.1   0.1   2.8e-50   7.3e-47       2     108 ..     159     264 ..     158     277 .. 0.95
   2 !   92.9   0.4   9.5e-30   2.4e-26     109     247 .]     290     407 ..     284     407 .. 0.83

  Alignments for each domain:
  == domain 1  score: 160.1 bits;  conditional E-value: 2.8e-50
       GCD14   2 fvyvlaptPeLWtlaLphrtqilytaDisliimkLelkpGsvvvesGtGsgslshaiartvaPtGhlftfefheqraekareefrehelsqlvtvthrD 100
                 fvyvl+ptP LWtl+L+hrtqily aDisli ++++l+pGsvv+e+GtGsgsls++i+r++ P Ghlftfe+h++r+ +a++ef++++l  ++t+t+ D
  EFC38593.1 159 FVYVLKPTPHLWTLVLKHRTQILYHADISLILTHFKLRPGSVVIEAGTGSGSLSTSISRAIMPNGHLFTFEYHKERYLHAMNEFKNNGLY-NITITNGD 256
                 9***************************************************************************************96.699***** PP

       GCD14 101 vckeGfde 108
                 vc++Gf+ 
  EFC38593.1 257 VCQNGFTP 264
                 ******54 PP

  == domain 2  score: 92.9 bits;  conditional E-value: 9.5e-30
       GCD14 109 evsgkvDavfLDlPaPweaiphaakalkkeggrlCsfsPCieqvqrtceaLrelgfteietlevllrtyevrkskleeidlaekrleenerkriekakr 207
                 + sg+vD vfLDlP+Pw  ip++++ l + gg++C fsPCieq+q+t++aLr+ +f+ei+ +e l+++y   +++++++d   k+ +++ ++       
  EFC38593.1 290 DKSGTVDGVFLDLPKPWLCIPNVFRLL-RVGGKFCGFSPCIEQIQETANALRQFDFVEIKCVECLVKEYMSNNVEVSTVDHYFKKSDTTTQQ------- 380
                 55789**********************.89***********************************************999877766665333....... PP

       GCD14 208 rkaskdakvedkssksstevllkPvselkghtgyLtfatk 247
                            +s++  ++ l   v e+kghtgyL+fatk
  EFC38593.1 381 -----------TSTT--EKRLFSAVPEMKGHTGYLIFATK 407
                 ...........1111..12222334499999999999985 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.0   2.1e-09   5.3e-06      63     139 ..     187     264 ..     139     276 .. 0.86

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 2.1e-09
                 HHHHHHTT--TT-EEEEES-TTSHHHHHHHHHHCTTCEEEEEESBHHHHHHHHHHHHHCTTCSEEEEES-G.GGTTGG CS
        PCMT  63 alalellelkkgarvLevGsGsGyltavlarlvgekgrvvsierikelveeakrnlkkldlenvivvvgDG.rkGyee 139
                 +l+l + +l++g+ v+e G+GsG l+  ++r + ++g++ + e+ ke + +a ++ k+++l n++++ gD  ++G+ +
  EFC38593.1 187 SLILTHFKLRPGSVVIEAGTGSGSLSTSISRAIMPNGHLFTFEYHKERYLHAMNEFKNNGLYNITITNGDVcQNGFTP 264
                 45677788**************************************************************51457765 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.0   6.8e-09   1.7e-05       4     130 ..     198     348 ..     195     383 .. 0.80

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 6.8e-09
  Methyltransf_31   4 glrvlDlGCGtGeltfelaeelgpkaevvGiDiseeaielArenaqklgldnveFeqgdieeleklled..ekfDlilsn.............. 81 
                      g +v+++G+G+G l+  + + + p+++++ +++ +e   +A ++ +++gl n++   gd+ +    +++   +  +ils+              
       EFC38593.1 198 GSVVIEAGTGSGSLSTSISRAIMPNGHLFTFEYHKERYLHAMNEFKNNGLYNITITNGDVCQNG--FTPntTTTPIILSDtlrpkyepsqilge 289
                      6789****************9***************************************9955..5543366777888888888888877777 PP

  Methyltransf_31  82 .......evlnaladpdkileeiervlkpggilliedprllaelpakveeeskay........e 130
                             +v+ +l+ p  ++ +++r+l+ gg ++  +p+     +++++e+ +a+        +
       EFC38593.1 290 dksgtvdGVFLDLPKPWLCIPNVFRLLRVGGKFCGFSPC-----IEQIQETANALrqfdfveiK 348
                      777666666699999999999******************.....78888887766555555552 PP

>> Methyltransf_4  Putative methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.0   1.2e-05     0.031       3      60 ..     199     257 ..     197     270 .. 0.90
   2 ?   -2.6   0.0       1.2   3.2e+03      71      84 ..     293     306 ..     291     307 .. 0.88
   3 ?   -2.9   0.1       1.6   4.1e+03     112     143 ..     344     378 ..     330     389 .. 0.51

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.2e-05
                     EEEEEET-TTSHHHHHHHHH.STTSEEEEEES-HHHHHHHHHHHHHCTTSSEEEEES-C CS
  Methyltransf_4   3 pvvleiGcGkGeflvalAkk.nPdknflGiEirvkvvakvlkkiealelkNlrilrgda 60 
                     +vv+e G+G+G++   ++ +  P+  ++  E ++++  +++++ ++++l N+ i++gd 
      EFC38593.1 199 SVVIEAGTGSGSLSTSISRAiMPNGHLFTFEYHKERYLHAMNEFKNNGLYNITITNGDV 257
                     689**************98648***********************************96 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.2
                     TSEEEEEEES---- CS
  Methyltransf_4  71 gslekifilFPDPw 84 
                     g+++++f+  P Pw
      EFC38593.1 293 GTVDGVFLDLPKPW 306
                     7899********** PP

  == domain 3  score: -2.9 bits;  conditional E-value: 1.6
                     EEEEEES...HHHHHHHHHHHHHCSTTEEESSCCC CS
  Methyltransf_4 112 vlelaTD...veeyaeemlkvleeeplferlskee 143
                     ++e++     v+ey+ + ++v      f++ + ++
      EFC38593.1 344 FVEIKCVeclVKEYMSNNVEVSTVDHYFKKSDTTT 378
                     44444433445555555555555555555444444 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   2.8e-05     0.072       1      64 [.     201     266 ..     201     286 .. 0.88
   2 ?   -3.2   0.0       5.7   1.5e+04      62      70 ..     339     347 ..     325     374 .. 0.56

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.8e-05
                      EEEET-TTSHHHHHHHCTS.TSSEEEEEESSHHHHHHHHHHHHHTTT.TEEEEESBCCGBSSSTTT CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrl.gkakvtgvDiseemleaareraeeegl.nvefvqgdaedlpfedgs 64 
                      v+++G+G+G l+  +++++ +++++  +++ +e   +a ++++++gl n+++ +gd+ +  f  ++
       EFC38593.1 201 VIEAGTGSGSLSTSISRAImPNGHLFTFEYHKERYLHAMNEFKNNGLyNITITNGDVCQNGFTPNT 266
                      789***************9879***********************************987776554 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 5.7
                      TTTEEEEEE CS
  Methyltransf_25  62 dgsfDlvvs 70 
                       ++fD+v +
       EFC38593.1 339 LRQFDFVEI 347
                      334444433 PP

>> GCD14_N  tRNA methyltransferase complex GCD14 subunit N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   1.8e-05     0.047       5      49 ..      87     131 ..      83     133 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.8e-05
     GCD14_N   5 raGdrVqLtDaKgrkhtitLepGgefhthrGaieHDdlIGrpeGs 49 
                 r+Gd V +  +   +   + ++G +f +  G++ H+++IG+p Gs
  EFC38593.1  87 REGDLVVFFINHDIMKAEVIKKGHTFDCRFGSFLHENIIGKPFGS 131
                 677777777777777788999********************9886 PP

>> Methyltr_RsmB-F  16S rRNA methyltransferase RsmB/F
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0         2   5.1e+03     104     126 ..      39      61 ..      21      69 .. 0.57
   2 ?    7.3   0.0    0.0013       3.3       5      70 ..     194     259 ..     190     275 .. 0.90
   3 ?    1.7   0.0     0.065   1.7e+02     103     138 ..     371     406 ..     359     410 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 2
                      H--HHHHHHHHHHHHHHHHHHCC CS
  Methyltr_RsmB-F 104 rrkekdiaqlaklqkellsaaid 126
                      r   +    l + +k ll ++++
       EFC38593.1  39 RNALQKTEDLEQIRKTLLLSLVP 61 
                      33333444455555555555555 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0013
                      ---TT-EEEESS-TTSHHHHHHHHHTTTTSEEEEEESSCCCHHHHHHHHHHTT--SEEEEES-CTC CS
  Methyltr_RsmB-F   5 apqeeetilDlcaaPGgKTthiaelmknkgtvvAvdankeRlkrvaenlkrLgvtntivleaDark 70 
                      +++++  ++++ ++ G+  t i+  + ++g+++  + +keR  + ++  k  g+ n++++++D+ +
       EFC38593.1 194 KLRPGSVVIEAGTGSGSLSTSISRAIMPNGHLFTFEYHKERYLHAMNEFKNNGLYNITITNGDVCQ 259
                      567778899999999**********9*************************************987 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.065
                      HH--HHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEE CS
  Methyltr_RsmB-F 103 lrrkekdiaqlaklqkellsaaidllkkgGvlvYsT 138
                      +++++++ +q ++ +k+l+sa+ ++  + G+l+++T
       EFC38593.1 371 FKKSDTTTQQTSTTEKRLFSAVPEMKGHTGYLIFAT 406
                      5788999999***********999999*******99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (412 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       916  (0.0510904); expected 358.6 (0.02)
Passed bias filter:                      622  (0.0346924); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.64u 0.34s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 2377.65
//
Query:       EFC38594.1  [L=347]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00014   21.8   0.8    0.00014   21.8   0.8    3.3  3  SNARE           SNARE domain
  ------ inclusion threshold ------
      0.037   13.1   2.7      0.053   12.6   2.7    1.1  1  Latrophilin     Latrophilin Cytoplasmic C-terminal region
      0.039   13.7   5.6       0.76    9.6   0.0    3.7  3  Synaptonemal_3  Synaptonemal complex central element protein 
       0.77    9.3  21.2       0.22   11.0   3.2    2.3  2  MscS_porin      Mechanosensitive ion channel porin domain
       0.97    8.6  19.1       0.11   11.7   1.7    2.4  2  TMPIT           TMPIT-like protein
        1.3    8.7   4.0        3.1    7.5   4.0    1.6  1  DUF3149         Protein of unknown function (DUF3149)
        1.7    6.5  21.8      0.023   12.7   3.5    2.1  2  Prominin        Prominin
        6.7    6.6  11.9         15    5.4   0.1    2.3  2  PDDEXK_6        PDDEXK-like family of unknown function


Domain annotation for each model (and alignments):
>> SNARE  SNARE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.3      0.14     3e+02       5      26 ..     131     152 ..     130     161 .. 0.87
   2 ?   -1.9   0.1       1.5   3.4e+03      16      31 ..     234     249 ..     232     250 .. 0.84
   3 !   21.8   0.8   6.1e-08   0.00014       2      50 ..     280     328 ..     279     330 .. 0.96

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.14
                 HHHHHHHHHHHHHHHHHHHHHH CS
       SNARE   5 rIdtnVenaqsnveraqkeLkk 26 
                 r+ +++  a s++++ +keL+k
  EFC38594.1 131 RLNNDINKAISKMDKEMKELDK 152
                 6788999999**********99 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.5
                 HHHHHHHHHHHHHHHH CS
       SNARE  16 nveraqkeLkkavkyq 31 
                 +++++ +++ +a ++q
  EFC38594.1 234 DISEGLEQIEQAKRQQ 249
                 6788999999999998 PP

  == domain 3  score: 21.8 bits;  conditional E-value: 6.1e-08
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTXXXXXXXXXXXXXXXXX CS
       SNARE   2 mvDrIdtnVenaqsnveraqkeLkkavkyqksnRklkciillilviill 50 
                 ++D + ++V+  +  +++ +k+++ a +++  + +l++i+++++vi+ l
  EFC38594.1 280 LLDKMSSDVDKYNKQLDDTNKRMVEAIEKAGGATRLLIILIILIVIVAL 328
                 79********************************************987 PP

>> Latrophilin  Latrophilin Cytoplasmic C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   2.7   2.3e-05     0.053     169     318 ..      74     245 ..      70     267 .. 0.53

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.3e-05
                  XXXXXXXXXX.........................XXXXXXX....XXXXXXXX.............XXXXXXXXXXXX...XXXXXXXXXXXXXXXX CS
  Latrophilin 169 ElvhNnlrgrlnaker..ekerelerklpkq..tvsggargs....gsgeeddaivadae....akkeegkeeelelEl...lreeleaPLlpqRaqs 251
                  E+v Nn+  + + + +  +k+ ++  k ++q  +v+++++++       ++ +   +da+     +k  +k ++   El   ++e+l++ Ll +  q 
   EFC38594.1  74 EVVDNNMDKQKQIEMQefQKKLKKLDKFERQkvMVKQAIDQAesllQ--QKKKQSGTDARlnndINKAISKMDKEMKELdkiHQEALNKKLLWKEIQM 169
                  78888888775555553422222222222220022222222233331..2222223333332222222222233333446679999*****9999887 PP

                  XXXXX.....XXXXXXXXXXXXXXXXXXXX.........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Latrophilin 252 llyqsqkrlldqeesesftaelteeteeee.........ssPnrDSLYtSmpnLrdspypdsspeeleelsssaqs 318
                  + +  ++r++d ++ +++ +  ++e+++           + P+rD  + S+ nL+    +  + + +e l++ +q+
   EFC38594.1 170 PVELRKQRESDIKNFRDYIKFVKAEHKKLLtgmmdddddDIPRRDVKFESIDNLQKAKNEVPTVDISEGLEQIEQA 245
                  77777667766666666666555555444455556666699*************9877443333333333333332 PP

>> Synaptonemal_3  Synaptonemal complex central element protein 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00034      0.76      49      82 ..      52      85 ..      46      96 .. 0.85
   2 ?    2.3   0.6     0.062   1.4e+02      16      34 ..     131     149 ..     112     171 .. 0.69
   3 ?    1.8   0.2     0.092   2.1e+02       6      32 ..     276     302 ..     270     315 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00034
  Synaptonemal_3 49 lrtnPdlaeslrrledeflkCkavlcsladeqek 82
                    +rt+P +a+ +rrl +  ++C  v+ +  d+q++
      EFC38594.1 52 FRTSPGMADLFRRLYQIRIDCGEVVDNNMDKQKQ 85
                    7***********************9999998764 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.062
  Synaptonemal_3  16 keslqlnkdleklteqmed 34 
                     +   ++nk + k+  +m +
      EFC38594.1 131 RLNNDINKAISKMDKEMKE 149
                     4445666666666666654 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.092
  Synaptonemal_3   6 seerqyedfskeslqlnkdleklteqm 32 
                      + ++ + +s+   + nk+l+    +m
      EFC38594.1 276 KQAQLLDKMSSDVDKYNKQLDDTNKRM 302
                     556777888888888888886544443 PP

>> MscS_porin  Mechanosensitive ion channel porin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7  10.1     0.017        38       5      66 ..      95     156 ..      85     167 .. 0.85
   2 ?   11.0   3.2   9.9e-05      0.22      59     140 ..     219     299 ..     217     311 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.017
  MscS_porin   5 lekakldeaeqkallqdLeqalnlLdkidkskkkaeelqkaiddaPkelrelqqelealqkk 66 
                 l+k ++ e ++  ++q++ qa +lL++++k+    + l+  i++a  ++++  +el++  ++
  EFC38594.1  95 LKKLDKFERQKVMVKQAIDQAESLLQQKKKQSGTDARLNNDINKAISKMDKEMKELDKIHQE 156
                 45555556899999*******************************************99333 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 9.9e-05
  MscS_porin  59 elealqkkkeeaskeilaklsleeLeqrllqtssqlqelqeqlaqlnsqlvelqtrperaqqqltearqrlqeirnrLnsta 140
                 ++++l +k+++++++ + +  le++eq   q++++   l +q++++   ++++++ +++  q l +++   ++ +++L++t 
  EFC38594.1 219 SIDNL-QKAKNEVPTVDISEGLEQIEQAKRQQEEKIDILLNQIQKIGGIANSISDELDKQAQLLDKMSSDVDKYNKQLDDTN 299
                 78999.778888888888899*********************************************************9883 PP

>> TMPIT  TMPIT-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   9.9     0.041        92       5      78 ..      89     160 ..      74     230 .. 0.54
   2 ?   11.7   1.7     5e-05      0.11       4      73 ..     239     308 ..     236     317 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.041
       TMPIT   5 eelekefkeleeta...keykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelkeelker 78 
                 +e++k++k+l + +     +kq +++ ++l ++ +k+  +  +  ++++++++k++k++k     e++++++e  ++
  EFC38594.1  89 QEFQKKLKKLDKFErqkVMVKQAIDQAESLLQQKKKQSGTDARLNNDINKAISKMDKEMK-----ELDKIHQEALNK 160
                 333443333333220002233333333333333333333333333333333333333333.....222222222222 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 5e-05
       TMPIT   4 weelekefkeleetakeykqkleelsklqskcskeikkqkkrlkelksslkklkksvkeeeeeeveelke 73 
                 +e++e+  ++ ee+ + + ++++++    +++s e++kq + l +++s+++k++k++++ +++ ve +++
  EFC38594.1 239 LEQIEQAKRQQEEKIDILLNQIQKIGGIANSISDELDKQAQLLDKMSSDVDKYNKQLDDTNKRMVEAIEK 308
                 678999999999999******************************************9999999999887 PP

>> DUF3149  Protein of unknown function (DUF3149)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   4.0    0.0014       3.1       9      31 ..     317     339 ..     316     342 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0014
     DUF3149   9 vGLlSliVIvftigmgaffiryF 31 
                 ++L++liVIv+ +g+g   + +F
  EFC38594.1 317 IILIILIVIVALLGIGWLLLELF 339
                 6899***********98888777 PP

>> Prominin  Prominin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4  11.9      0.18     4e+02     616     692 ..      78     160 ..      68     203 .. 0.63
   2 ?   12.7   3.5     1e-05     0.023     314     435 ..     205     329 ..     173     335 .. 0.61

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.18
    Prominin 616 qlckkltkvnletlaekleelanelsngk.....knlkqslkneaqdlraiqqelvlplessvkklkksvkklde.ensdlqe 692
                 +  +k  +++++++++kl++l +   ++       +  +sl +++++ +  ++ l+  ++++++k+ k++k+ld+ +++ l++
  EFC38594.1  78 NNMDKQKQIEMQEFQKKLKKLDKFERQKVmvkqaIDQAESLLQQKKKQSGTDARLNNDINKAISKMDKEMKELDKiHQEALNK 160
                 33344488999999999999877665543555555555566666666666777777778888888888888888863333332 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 1e-05
    Prominin 314 l..dqlpnvdevlealeevletnlssivkeglarlneipekvknqtaevvpdlkkalakgreqikklakkip..realdavisdlenterssk.tfddv 407
                    d +p  d   e+++++ +++ +    +  + l++i++ +k+q +e +  l ++++k++   ++++ ++    + ld+++sd+++ +++++ t+++ 
  EFC38594.1 205 DddDDIPRRDVKFESIDNLQKAKNEVPTVDISEGLEQIEQ-AKRQQEEKIDILLNQIQKIGGIANSISDELDkqAQLLDKMSSDVDKYNKQLDdTNKRM 302
                 2348899999999999999888877666666666777765.4445555556666666666655555555553326778888888887777765144455 PP

    Prominin 408 vekyekyrwliglivcsllllivvilil 435
                 ve  ek   +  l+++ l++liv++ +l
  EFC38594.1 303 VEAIEKAGGATRLLII-LIILIVIVALL 329
                 5555555555544443.33344444444 PP

>> PDDEXK_6  PDDEXK-like family of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   7.2     0.027        60       6      92 ..      78     160 ..      73     169 .. 0.58
   2 ?    5.4   0.1    0.0068        15      32      78 ..     263     309 ..     198     324 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.027
    PDDEXK_6   6 sFleeeeeeseekeeeeerenefeee..seedsdeekd...sseeaaellkellesassaerklladvseavekakkevkkkeeekrsclrr 92 
                 + ++++++ +          +ef+++  + ++ +++k    ++ ++ae+l + ++++s + ++l +d+++a++k+ ke+k+ ++ ++++l++
  EFC38594.1  78 NNMDKQKQIEM---------QEFQKKlkKLDKFERQKVmvkQAIDQAESLLQQKKKQSGTDARLNNDINKAISKMDKEMKELDKIHQEALNK 160
                 34444333222.........233333212222222222333666777888888999999***************999988655544444443 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0068
    PDDEXK_6  32 seedsdeekdsseeaaellkellesassaerklladvseavekakke 78 
                      ++ +d+ +++a+ll++++++ ++++++l ++ +++ve+ +k+
  EFC38594.1 263 IGGIANSISDELDKQAQLLDKMSSDVDKYNKQLDDTNKRMVEAIEKA 309
                 23333444558889999999999999***999999999999997665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3011  (0.16794); expected 358.6 (0.02)
Passed bias filter:                      731  (0.0407719); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.79u 0.35s 00:00:01.14 Elapsed: 00:00:00.52
# Mc/sec: 1999.73
//
Query:       EFC38595.1  [L=444]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0069   16.3   0.9        1.4    8.9   0.2    3.3  3  UME       UME (NUC010) domain


Domain annotation for each model (and alignments):
>> UME  UME (NUC010) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       0.1   1.8e+03      36      56 ..      32      53 ..      26      97 .. 0.60
   2 !    8.9   0.2   7.8e-05       1.4      27      62 ..     164     199 ..     131     225 .. 0.80
   3 !    3.7   0.0    0.0032        57      27      79 ..     279     344 ..     264     351 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.1
         UME 36 leeliklagssissalp.qima 56
                +++li l ++  s+++  qi +
  EFC38595.1 32 MSFLITLKKGVHSTVVSqQIQS 53
                5555555555433333313322 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 7.8e-05
         UME  27 aekkraikaleeliklagssissalpqimacLqsal 62 
                  e++ +i a+e++ +  ++ +s +lpq+ ++L +  
  EFC38595.1 164 YERESCIIAIEQICSTSKHFASQILPQLETLLSDIK 199
                 699************************999887655 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.0032
         UME  27 aekkraikaleeliklagssissalp.............qimacLqsaleidelrsaalsvWatll 79 
                 + k+ ai+ +  l k ++   +   p             qi+ +L++ l++  + s+ l v + l+
  EFC38595.1 279 KVKISAINNITNLSKTLSDTYTFEFPfkvritiifieflQILKILHDSLNNSPFDSVKLAVLRLLA 344
                 347777777777777777775555557777777788888************999999999887775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (444 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       601  (0.0335211); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 2919.68
//
Query:       EFC38596.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.038   13.3   2.1        0.5    9.7   0.1    2.6  2  Herpes_UL69  Herpesvirus transcriptional regulator family
      0.054   13.9   0.1       0.15   12.5   0.1    1.8  1  hSH3         Helically-extended SH3 domain


Domain annotation for each model (and alignments):
>> Herpes_UL69  Herpesvirus transcriptional regulator family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.1   5.6e-05       0.5      14      68 ..     135     188 ..     123     196 .. 0.89
   2 ?    2.0   0.2     0.013   1.1e+02      58     103 ..     207     252 ..     194     269 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 5.6e-05
  Herpes_UL69  14 krkeLrdfltkeenkslavdlrkevianasLitllafadEtltwlklhllhnlpl 68 
                  + k+L + l+++en+    d+ ++ i ++ L +   ++dEtl++lk   ++n+ +
   EFC38596.1 135 YLKSL-RLLSESENSLNTEDKFQKEISSSALEKCKNTLDETLMFLKASGVNNCGF 188
                  55778.8999*************************************99999865 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.013
  Herpes_UL69  58 lklhllhnlplnpkDlilstagallealvtKLkpllsClldnrked 103
                  +  +++hn p + +D i++  + l   l  K++++++ ++d  +++
   EFC38596.1 207 IHHMANHNKPTSLNDTIFHHQAQLFIVLNDKFNDMINSFFDIDHNS 252
                  566789***************************9999999877766 PP

>> hSH3  Helically-extended SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   1.7e-05      0.15      40      77 ..     426     463 ..     380     468 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.7e-05
        hSH3  40 ildviqktddkkvlcr.neeGkygyvlrsalleedgeiY 77 
                 i+ vi+++ +kk +c  n+eG+y+ v +++++ ++++ Y
  EFC38596.1 426 IVPVIEQSFQKKCICHfNTEGRYQLVIKTQMI-DENDCY 463
                 678************769********998885.444554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1020  (0.0568911); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2954.77
//
Query:       EFC38597.1  [L=620]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-40  138.9   0.7      6e-39  133.6   0.0    2.9  3  DEAD        DEAD/DEAH box helicase
    5.7e-20   71.7   0.5      2e-19   70.0   0.0    2.2  2  Helicase_C  Helicase conserved C-terminal domain
    2.2e-12   47.0   0.1    4.8e-12   45.9   0.1    1.6  1  DUF4217     Domain of unknown function (DUF4217)
     0.0054   16.7   0.0     0.0054   16.7   0.0    2.8  2  ResIII      Type III restriction enzyme, res subunit
  ------ inclusion threshold ------
      0.032   13.6   0.1      0.032   13.6   0.1    3.2  3  CMS1        U3-containing 90S pre-ribosomal complex subunit
      0.089   12.5   2.9        6.2    6.6   0.0    3.6  4  DUF4116     Domain of unknown function (DUF4116)
        1.6    8.8   5.3        2.3    8.3   3.4    2.4  1  GvpG        Gas vesicle protein G
        3.9    8.0  10.5        1.3    9.5   0.4    2.8  2  Pox_H7      Late protein H7


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  133.6   0.0   2.7e-42     6e-39       2     175 ..       3     198 ..       2     199 .. 0.89
   2 ?   -1.7   0.0      0.95   2.1e+03     135     165 ..     306     333 ..     302     335 .. 0.75
   3 ?    2.1   0.1     0.067   1.5e+02      48     121 ..     466     540 ..     410     545 .. 0.68

  Alignments for each domain:
  == domain 1  score: 133.6 bits;  conditional E-value: 2.7e-42
                 HHHHHHHHHHHTTCEEEEEESTTSSHHHHHHHHHHHHHHHS.............TTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   2 diQaeaiplilgggdvlvaaeTGsGKTlaflipvlqivyet.............kgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaa 87 
                 ++Q+++ipl+l+++dv+v+a TGsGKTlaf+ip++q ++ +              ++++   +++ PtreLa+q+++ + kf  +++l+v+l+igg+++
  EFC38597.1   3 PVQENTIPLLLNNKDVVVQALTGSGKTLAFIIPIFQYIIARqfegkipsmeemmPRRKNVYSIVLLPTRELARQVYDVACKFAPKTNLNVKLFIGGEER 101
                 89***********************************99989999999999999788889***********************************9666 PP

                 HHHHHHH.............HTT....CSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTTSTTTSEEEEEESSB CS
                 xxxxxxx.............xxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  88 rdqlskl.............dng....vdivvgtpgrlddllstgklnlsqvrflVlDEadrlldqgfsdfinrilnqlpqitcdgklqrqvivlSATl 169
                 +  + +              + +    ++i +gtpgr++d l+++ l+++ +++l++DEad +l++gf++++++il++l       ++qr++ ++SAT 
  EFC38597.1 102 ETLQPATgfdsseksglnasE-NlfldCNIAIGTPGRILDYLNSKLLKVRCLEILIIDEADIILNMGFRQQVDQILSHL-------PKQRRTGLFSATQ 192
                 555544466666655555432.25778****************9***********************************.......78999*******9 PP

                 SHHHHH CS
                 xxxxxx RF
        DEAD 170 pkdvkk 175
                 ++++++
  EFC38597.1 193 TSELDD 198
                 988776 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.95
                 HTTTHHHHHHHHHHSHHHCTTSTTTSEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD 135 dqgfsdfinrilnqlpqitcdgklqrqvivl 165
                  q+f++ +++i++ql+q   ++k    v+++
  EFC38597.1 306 HQSFKEACENIAKQLDQSVVSKK---AVLFC 333
                 579999*********77766544...36666 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.067
                 -EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHHTT.CSEEEEEHHHHHHHHHCTSSHCTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  48 pkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskldng.vdivvgtpgrlddllstgklnlsq 121
                   +++  Pt   ++q+++ +k  ++ id++        +++  +++l+++  +  +   +rl+++ ++++ + s+
  EFC38597.1 466 AYCILTKPTIREIKQQMESIKLPFEDIDINSIPYKDARREKARKERLKKQeENEKIWEEKRLQKIAEKKEEKKSS 540
                 6899999999999********999988855543334444445555554334666666777777777544434455 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.0   0.0   8.8e-23     2e-19       2     111 .]     240     372 ..     239     372 .. 0.81
   2 ?   -3.0   0.1       4.2   9.5e+03      24      62 ..     473     515 ..     460     521 .. 0.65

  Alignments for each domain:
  == domain 1  score: 70.0 bits;  conditional E-value: 8.8e-23
                 HHHHHHHHH...HHTTTTSEEEEEESSHHHHHH.HHHH.....HHHT..TSTEEEESTTSTHHHHHHHHHHHHTTS.............SS.EEEESGG CS
  Helicase_C   2 kleallell...kleeeggkilifvntidrlek.vkll.....lekk..gikvavlhgelpqnereeileqfnkge.............sd.vLiatdv 75 
                 kl++l++l+   +   +g+ ++++  t+  ++   kll     +  +   i+   lhg++ q+ r++  ++f++                + vL +tdv
  EFC38597.1 240 KLNYLIHLIkndDPIPSGNSVIVYFLTCAAVDFfSKLLkevlgK--NeeTIQLFSLHGQMVQKRRNAEHQSFKEACeniakqldqsvvsKKaVLFCTDV 336
                 67777777755444457888899999999887764444444333..2458****************99999986556888889999998555******* PP

                 GTSSSTSTTESEEEESSSSSSHHHHHHHHTTSSSTT CS
  Helicase_C  76 aerGidipkvnlVinfdlprnvtsyiqriGRtgRag 111
                 a+rG+d+p++ ++++fd+p+n++++++r+GRt+R+g
  EFC38597.1 337 AARGLDFPNIATIVQFDAPTNPDQFVHRVGRTARMG 372
                 **********************************86 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.2
                 SSHHHHHH.HHHHHHHT...TSTEEEESTTSTHHHHHHHHHHH CS
  Helicase_C  24 ntidrlek.vklllekk...gikvavlhgelpqnereeileqf 62 
                 +ti+++++ ++ ++  +   +i+++++      + r+e l++ 
  EFC38597.1 473 PTIREIKQqMESIKLPFediDINSIPYKDARREKARKERLKKQ 515
                 5666665554444333344478888888888888888877765 PP

>> DUF4217  Domain of unknown function (DUF4217)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.9   0.1   2.1e-15   4.8e-12       5      61 .]     419     475 ..     416     475 .. 0.94

  Alignments for each domain:
  == domain 1  score: 45.9 bits;  conditional E-value: 2.1e-15
     DUF4217   5 leslcakdrdlkelAqkAfvsyvraYsvhlakeiFrvkkLdlealAksfGLleaPki 61 
                 l++++++drd++e++ +A +s+vr+Y++h++++iF++ kL +++l ++++ l  P i
  EFC38597.1 419 LKKIIKSDRDVFEKGEEALKSFVRSYKEHQCSYIFKFAKLRFDQLLEAYCILTKPTI 475
                 89*******************************************999999988875 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.4e-06    0.0054      23     146 ..      14     165 ..       4     193 .. 0.68
   2 ?   -5.5   6.5         8   1.8e+04      82     136 ..     515     570 ..     476     582 .. 0.47

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.4e-06
                 TTSEEEEEESTTSTHHHHHHHHHHHH-S.....................-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--......... CS
      ResIII  23 rdkrglikmaTGtGKTlvaaklierllkkgkee................kflflvprkslleqtleefkkflseaykeigkkvsgdkkka......... 96 
                 ++k +++++ TG+GKTl  +  i ++  +++ e                  ++l p+++l  q ++   kf+++++ +++ ++ g++++          
  EFC38597.1  14 NNKDVVVQALTGSGKTLAFIIPIFQYIIARQFEgkipsmeemmprrknvYSIVLLPTRELARQVYDVACKFAPKTNLNVKLFIGGEERETlqpatgfds 112
                 678999*************9999999999888899************87779999********************999888888888887666555555 PP

                 ...............-SEEEEEHHHHHHTH........HHHTTT-SEEEEETGGGTTS CS
      ResIII  97 ........kekdstnkkilvttiqsldadseeeeeeseellrdrfdviiiDEaHrlga 146
                         +e+   +++i + t  ++   +     +s+ l+    +++iiDEa  +  
  EFC38597.1 113 seksglnaSENLFLDCNIAIGTPGRILDYL-----NSKLLKVRCLEILIIDEADIILN 165
                 543332222222223333333333333333.....33333333334777777655555 PP

  == domain 2  score: -5.5 bits;  conditional E-value: 8
                 ...GEEEESSS-B--.........-SEEEEEHHHHHHTH........HHHTTT-SEE CS
      ResIII  82 ykeigkkvsgdkkka..kekdstnkkilvttiqsldadseeeeeeseellrdrfdvi 136
                 ++e++k++++++ ++  + k++++k+ +    +++ ++s+  + e+++l ++ ++  
  EFC38597.1 515 QEENEKIWEEKRLQKiaE-KKEEKKSSVNYLKDKVRNRSDISTHEKKRLYNQLENQQ 570
                 222444444444444431.22222222222222222222222222222222222233 PP

>> CMS1  U3-containing 90S pre-ribosomal complex subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1   1.4e-05     0.032     179     209 ..     129     159 ..     127     163 .. 0.93
   2 ?   -0.3   0.0      0.25   5.6e+02     104     165 ..     235     296 ..     222     303 .. 0.63
   3 ?   -5.2   9.1       7.5   1.7e+04       5      54 ..     510     558 ..     499     576 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.4e-05
        CMS1 179 giavGtpgRildLleeeslsvdeLkrivlDa 209
                  ia+GtpgRild l+ + l+v  L+ +++D 
  EFC38597.1 129 NIAIGTPGRILDYLNSKLLKVRCLEILIIDE 159
                 69***************************96 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.25
        CMS1 104 pdyleelsefakklvksaksngsPe...lLvltlaalRaaD.laralkklqtkdskvakLFakhik 165
                  dy ++l  +  +l+k+     s +   + +lt aa+   D  ++ lk++  k+++  +LF+ h +
  EFC38597.1 235 CDYRQKLNYLI-HLIKNDDPIPSGNsviVYFLTCAAV---DfFSKLLKEVLGKNEETIQLFSLHGQ 296
                 55555665554.5555544333333000345555554...5258999**************99965 PP

  == domain 3  score: -5.2 bits;  conditional E-value: 7.5
        CMS1   5 erkrkaenkekgkkkksekkRskkkerkkgklketqDvkaglteavalqd 54 
                 er +k+e++ek   +k+ +k   kke+kk+ ++ ++D k     ++   +
  EFC38597.1 510 ERLKKQEENEKIWEEKRLQKIAEKKEEKKSSVNYLKD-KVRNRSDISTHE 558
                 4555555666666666666667777777777777776.323333444444 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.0    0.0028       6.2      22      47 ..      11      36 ..       7      38 .. 0.87
   2 ?   -3.1   0.0         3   6.8e+03      11      24 ..     134     147 ..     130     154 .. 0.70
   3 ?   -3.5   0.1       4.1   9.1e+03      16      28 ..     241     253 ..     240     254 .. 0.79
   4 ?    3.8   0.5     0.021        46      26      42 ..     415     431 ..     394     457 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0028
     DUF4116 22 eLknDkeivlkAvkqngtalsyasee 47
                 L n+k++v +A+  +g+ l ++ + 
  EFC38597.1 11 LLLNNKDVVVQALTGSGKTLAFIIPI 36
                699***********999999998765 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3
     DUF4116  11 kngsalkylseeLk 24 
                 + g +l yl+++L 
  EFC38597.1 134 TPGRILDYLNSKLL 147
                 55667778877774 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 4.1
     DUF4116  16 lkylseeLknDke 28 
                 l+yl + +knD  
  EFC38597.1 241 LNYLIHLIKNDDP 253
                 6788899999976 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.021
     DUF4116  26 DkeivlkAvkqngtals 42 
                 +k++++k++k++ ++++
  EFC38597.1 415 NKDVLKKIIKSDRDVFE 431
                 89999999999998774 PP

>> GvpG  Gas vesicle protein G
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   3.4     0.001       2.3      12      69 ..     541     612 ..     538     619 .. 0.66

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.001
        GvpG  12 viWiaeqvqeraeeqlddqenlrkeL........aaLqqeLdaGeIdeeeFdr......rEeelLdrLeale 69 
                 v  + ++v +r +   ++++ l  +L        a L ++L++G+I+eee++r       E e++ +L + +
  EFC38597.1 541 VNYLKDKVRNRSDISTHEKKRLYNQLenqqfndeALLLKRLKRGKISEEEYERlsgeskLEGEIMKKLSERK 612
                 5566778888888888888888888833333332347789************83332223666777776555 PP

>> Pox_H7  Late protein H7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.4    0.0006       1.3      65     121 ..     398     453 ..     385     464 .. 0.78
   2 ?    1.5   4.0      0.18     4e+02      98     134 ..     499     535 ..     469     547 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.0006
                 --EE--HHHHHHTHHHHHHHHHHHHHHHH-HHHHHHH-HHHHHHHHHHT--XXXXXX CS
      Pox_H7  65 klkkltpdeyaahsaaiakeltaadiilediedyikeskklkrvikvyktkkrkkik 121
                 ++++l p +  + ++ + k +    ii+ d + + k  + lk +++ yk ++   i 
  EFC38597.1 398 SMHELEPTDEMKKTNYVNKDVL-KKIIKSDRDVFEKGEEALKSFVRSYKEHQCSYIF 453
                 4567778888888888887765.5799*********************887766655 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.18
                 HHHH-HHHHHHHHHHT--XXXXXXXXXXXXXXXXXXX CS
      Pox_H7  98 yikeskklkrvikvyktkkrkkikeakkklkiAlkkg 134
                 y  ++ +  r  ++ k+++++ki e k+ +kiA+kk+
  EFC38597.1 499 YKDARREKARKERLKKQEENEKIWEEKRLQKIAEKKE 535
                 44444444445577778****************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (620 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2100  (0.117129); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.81u 0.35s 00:00:01.16 Elapsed: 00:00:00.56
# Mc/sec: 3327.00
//
Query:       EFC38598.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.26   10.9  22.8        0.6    9.7  11.8    2.2  2  SR-25     Nuclear RNA-splicing-associated protein
        1.9    8.6   5.7       0.23   11.5   1.4    1.7  2  DUF4337   Domain of unknown function (DUF4337)


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  11.8   6.7e-05       0.6      36      84 ..      40      88 ..       5     103 .. 0.71
   2 ?    7.0   3.1   0.00045       4.1      87     121 ..     134     169 ..     118     203 .. 0.53

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 6.7e-05
       SR-25 36 sqsrkassasekeeerskekkkkkrrrssssssssssssssssssssss 84
                + +rk s++ +++ e+s +++ +  r+ ssss++ss ss  ssss+ s+
  EFC38598.1 40 DDRRKISTSRRSDWEKSPHRESNDYRQYSSSSNRSSNSSFRSSSSTHST 88
                4455666555556699******999999999999999998877766443 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.00045
       SR-25  87 ddrkkrgkkkdkkkkkkkkk.kkkkkekkkakekak 121
                 d++k+r+k+ d k+k+++ k k+k+++ +k+++ ++
  EFC38598.1 134 DENKNRKKEDDYKNKNRQFKnKEKRMSAQKSQQMKD 169
                 345555555555555555542233333333333222 PP

>> DUF4337  Domain of unknown function (DUF4337)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.2      0.41   3.6e+03      36      50 ..      60      74 ..      12     102 .. 0.64
   2 ?   11.5   1.4   2.6e-05      0.23      60     118 ..     130     188 ..     119     192 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.41
     DUF4337 36 asdqWafYQAksike 50
                +s+ +  Y + s+++
  EFC38598.1 60 ESNDYRQYSSSSNRS 74
                344444444444444 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 2.6e-05
     DUF4337  60 lelllkakaeelaaavdkkiakykkkiarykkekkeikkkAkeleaerdeaneasdkfd 118
                 l l  ++k++++++++++k++++k+k +r +++k++ +k+ +++e++r  ++ ++ +fd
  EFC38598.1 130 LYLGDENKNRKKEDDYKNKNRQFKNKEKRMSAQKSQQMKDNDAWERNRLLLTGNARTFD 188
                 55555666899999********************************9988888888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1794  (0.100061); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 1626.39
//
Query:       EFC38599.1  [L=916]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.4e-89  300.1  19.8    3.4e-89  300.1  19.8    1.5  2  Cullin        Cullin family
    1.4e-22   79.4   1.9    1.4e-22   79.4   1.9    2.4  2  Cullin_Nedd8  Cullin protein neddylation domain
  ------ inclusion threshold ------
      0.064   13.1   1.1       0.39   10.6   0.3    2.5  2  YmgB          Biofilm development protein YmgB/AriR
       0.11   12.6   3.4         14    5.9   0.0    3.8  5  Spo0A_C       Sporulation initiation factor Spo0A C terminal


Domain annotation for each model (and alignments):
>> Cullin  Cullin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  300.1  19.8   7.5e-93   3.4e-89       4     618 .]      34     809 ..      31     809 .. 0.87
   2 ?   -3.0   0.2      0.43   1.9e+03     114     154 ..     818     859 ..     812     904 .. 0.57

  Alignments for each domain:
  == domain 1  score: 300.1 bits;  conditional E-value: 7.5e-93
      Cullin   4 leeaiqeilk...knvsklsfeelYravynlvlsk......................ekkqgekLydklkelieehlkellkellkeesdeelLkalkk 77 
                 le  + ++l+   + + k++ e+l + vy+l + +                       + q   Ly  lk+li++hlk   ++l ++ ++  lLk++ +
  EFC38599.1  34 LEYDLAQVLTdplNATLKNDTEKLHNIVYKLSTGQcfnlpdgsilsqnphspsipqdGDIQPYTLYFMLKRLISNHLKLFISKL-NNLTGIPLLKQYFT 131
                 5556666665333344566678888888888887788888888888888888888884567899*****************987.8888888******* PP

      Cullin  78 eWedhktsmkmirdifmyldr.............................vyvk..klpsvydlglelfrdhvfr........................ 121
                  W+++ +++++i ++f+yl++                             ++++  ++ +++ ++l l+r+ +f+                        
  EFC38599.1 132 LWNNYLIACDFIMKVFHYLNSdwiteqeikrkskanqpekytersanqivHFSEsnHVCNTKLTCLLLWREWFFErcenlskplgyqeadsplieekev 230
                 ***************************9999999999999888888877633334466688889**********66*****************999887 PP

      Cullin 122 ..iklkdrlieallkliekeReg...........evid.rsllksviemlvelgedse..................................dkk.... 168
                      k  + + ++k ie++R+            e  +  ++lksvi +l  l+ dse                                  + +    
  EFC38599.1 231 tfD--KFGFYDVIMKIIEMDRNYnnpylknsfcvE--EfYPILKSVIGSLLYLSLDSEedfyfsvkykyypsmnlfeslnvhiedyyskildQ-Tmtwk 324
                 432..4669************88899887765432..2459**********999999999*****9999999999999999999888888751.24555 PP

      Cullin 169 ...vYeeeFekafleateefYraeaeella.......ensvaseYlkkaeerleeEeervek.yldsstkkkllevleeelikkhleelleee.....l 251
                    +Y  +Fe+ fle+++++Y ae ++ll        +++++++Y++++++rl++E+++    yl + t++++++++ + +i+   e++ + +     +
  EFC38599.1 325 ypiFYLYDFERIFLETSKRYYCAEIDSLLItylsgenHHDSVRKYIQHVSARLDQETNKNILhYLPQITRDNIQKIMCDLFIEGIKENMSSLNfilsdI 423
                 777999*******************999886666766588999*************9976655**************9999997776666665555559 PP

      Cullin 252 kkllede..kledLkrlykllsrv..d.gleeLrkaleeyikeeg.kaivkdakekektedakkyveklLelkdkfdklvkeafnndkefekaldeafe 344
                 ++++++    +++L++lyk++ +   +  l+eL +++++ i     +++ k +  +++t d++++++ +++ ++ f++++++ f+n+ e++ + d+ f+
  EFC38599.1 424 EAWINEPevYKDNLELLYKVITKSnrKiALNELGTRIRNRILFSLnSDMRKVKMISQDTYDPIQFIDVIIDNYNIFSSIIRQYFSNNYELNICKDKTFK 522
                 99996336799************9765889***********999989999999999******************************************* PP

      Cullin 345 efvnknkv.....nsksaellakYiDelLkkglkgl.....seeeleekldkvlvlfryiedKDvFekyYkkhLakRLllgksas....ddaEksmisk 429
                 ef+n+  +     n k+ae+l++Yi +lLk +++       ++ ++e+++d ++ l r ++d DvF +yYk  LakRLl  k +     ++ E  mi+k
  EFC38599.1 523 EFFNNAPIftsdpNMKCAEYLSRYINHLLKGSSRPTlncysDNLDIESRMDYAVYLCRLLNDVDVFIQYYKVLLAKRLLIFKYEGeatqEELEYTMITK 621
                 ****6666**********************98777778887899***********************************877654444499******** PP

      Cullin 430 LkeecGseftskLegMfkDiklskdlnkefkeyleeekkkkkkvdlsvkVLtagaWpterskese....vsvklpeeledlieeFeefYkskhsgrkLt 524
                 Lk+ c +  + k++ M++D++ +k l + f ++ e+ +++   +++++kVLt+g+Wp ++s+       + + +p+ +++ +++F+e+Y++ ++gr Lt
  EFC38599.1 622 LKKVCTFGHIYKIQTMLNDLNNAKSLAERFTKWNENGEAR---IQFTAKVLTKGYWPLNNSS--LitpsNAFCIPTTISERMNSFTEYYSKLYNGRHLT 715
                 *********************************9855555...**************87764..255889***************************** PP

      Cullin 525 Wlhslgsaelkatfpkk...kyelqvstfqmvvLllFndeeeklsyeeiqeatglpekeLkrtLqsLavakkarvLlkepks.kdveptdefsvNaeF 618
                 Wl  l+++ ++ +f+++    y+++vs++q  ++l+Fn+ e++ ++++++ a+g+p +eL +tL +++   + ++ + ++     + +++ +++N++F
  EFC38599.1 716 WLNILSKGVVRGHFTNSsmpYYDITVSLIQLSIFLQFNNGENSKTIQDLSLAVGIPIEELIQTLVPII---NFKIFTSSS-AiTSLDQSSIITINDSF 809
                 ****************777677****************97689************************9...788**9988.44899999999999998 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.43
      Cullin 114 lfrdhvfr...iklkdrlieallkliekeReg..evidrsllksvi 154
                 lf++++ +   +  ++  ++++l++i+++R+   +    +++ +++
  EFC38599.1 818 LFQHSIKQyyeEGKSNPANQKILAQIKEDRKYtlQ----AAIVRIL 859
                 55555554454222355677778888888855320....2222222 PP

>> Cullin_Nedd8  Cullin protein neddylation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.93   4.2e+03      14      33 ..     445     464 ..     444     483 .. 0.75
   2 !   79.4   1.9   3.2e-26   1.4e-22       1      62 [.     846     907 ..     846     908 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.93
  Cullin_Nedd8  14 MKsrktlshneLvsevieql 33 
                    Ks+++++ neL +++ + +
    EFC38599.1 445 TKSNRKIALNELGTRIRNRI 464
                   59999******998887665 PP

  == domain 2  score: 79.4 bits;  conditional E-value: 3.2e-26
  Cullin_Nedd8   1 dRklaiqaaIVRiMKsrktlshneLvsevieqlskrftpsiadikkrIesLiekeYleRden 62 
                   dRk+ +qaaIVRi+K+rk+++h++Lv+  ++qls++f+p+++dik+ I+sL+++eY++R  +
    EFC38599.1 846 DRKYTLQAAIVRILKTRKQIEHKQLVNLLLAQLSSNFKPTNSDIKRAIDSLLQQEYIKRVSE 907
                   8**********************************************************876 PP

>> YmgB  Biofilm development protein YmgB/AriR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.23     1e+03      10      29 ..     370     389 ..     364     392 .. 0.83
   2 ?   10.6   0.3   8.8e-05      0.39       5      46 ..     850     891 ..     846     897 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.23
                 HHHHHHTT---SHHHHHHHH CS
        YmgB  10 ireilasggkvtnKaIIlkL 29 
                 i+ ++a+ ++ tnK+I ++L
  EFC38599.1 370 IQHVSARLDQETNKNILHYL 389
                 778888888999****9987 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 8.8e-05
                 HHHHHHHHHHHTT---SHHHHHHHHHHHHHT---HHHHHHHH CS
        YmgB   5 vLgaiireilasggkvtnKaIIlkLiekLEsesdvvqldvyR 46 
                  L+a+i  il++ +++ +K++++ L+++L+s    ++ d+ R
  EFC38599.1 850 TLQAAIVRILKTRKQIEHKQLVNLLLAQLSSNFKPTNSDIKR 891
                 5899***************************99999999888 PP

>> Spo0A_C  Sporulation initiation factor Spo0A C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0       3.9   1.7e+04      59      81 ..     365     387 ..     362     390 .. 0.64
   2 ?    5.9   0.0     0.003        14       9      64 ..     408     464 ..     397     492 .. 0.81
   3 ?   -3.9   0.0       3.2   1.5e+04      12      30 ..     535     553 ..     534     558 .. 0.78
   4 ?   -0.1   0.1      0.22   9.8e+02      68     100 ..     811     843 ..     773     846 .. 0.78
   5 ?    4.3   0.1    0.0091        41      20      68 ..     851     901 ..     847     914 .. 0.78

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 3.9
     Spo0A_C  59 aIrhaIevaWekgnkekleelfg 81 
                 ++r+ I+++  + ++e+ +++++
  EFC38599.1 365 SVRKYIQHVSARLDQETNKNILH 387
                 45666777666666666666655 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.003
     Spo0A_C   9 GipaklkGykylreaielvledpellesitkelypevAkkykttp.srVeraIrhaI 64 
                 Gi+++++  +++ + ie  +++pe+ +   + ly+ + k   + + ++    Ir+ I
  EFC38599.1 408 GIKENMSSLNFILSDIEAWINEPEVYKDNLELLYKVITKSNRKIAlNELGTRIRNRI 464
                 99************************************9987643145555566555 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 3.2
     Spo0A_C  12 aklkGykylreaielvled 30 
                 +++k+ +yl++ i  +l+ 
  EFC38599.1 535 PNMKCAEYLSRYINHLLKG 553
                 6889999999999887765 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.22
     Spo0A_C  68 WekgnkekleelfgysinsekgkPtnsefiall 100
                 +++++++ +++ +++ +++ k++P n++++a +
  EFC38599.1 811 YQRNKISLFQHSIKQYYEEGKSNPANQKILAQI 843
                 566777788888888888889999999888876 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.0091
     Spo0A_C  20 lreaielvledpe..llesitkelypevAkkykttpsrVeraIrhaIevaW 68 
                 l+ ai  +l+ ++    +++ + l  +++ ++k t+s ++raI    ++ +
  EFC38599.1 851 LQAAIVRILKTRKqiEHKQLVNLLLAQLSSNFKPTNSDIKRAIDSLLQQEY 901
                 6677777777777344578899999******************98877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (916 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       896  (0.0499749); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.76u 0.31s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 5424.64
//
Query:       EFC38600.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-15   56.9   0.0    3.3e-15   56.1   0.0    1.4  1  KH_6      KH domain
     0.0021   18.0   0.4     0.0053   16.7   0.0    1.9  2  Rrp40_N   Exosome complex exonuclease Rrp40 N-terminal domain
  ------ inclusion threshold ------
       0.11   12.3   0.0         15    5.5   0.0    2.4  2  ECR1_N    Exosome complex exonuclease RRP4 N-terminal region


Domain annotation for each model (and alignments):
>> KH_6  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.1   0.0   5.6e-19   3.3e-15       1      45 [.     170     217 ..     170     218 .. 0.97

  Alignments for each domain:
  == domain 1  score: 56.1 bits;  conditional E-value: 5.6e-19
        KH_6   1 GmlfeVslslvrRll...nhvLeeLgkagpfeiavGlNGriWvksesp 45 
                 G++ e+sl+++r+ll   + +L+ L+++++feia+GlNGr+W++se+p
  EFC38600.1 170 GYVTECSLGMARKLLdpnCYLLKLLSEHVSFEIAIGLNGRVWINSEAP 217
                 99*******************************************987 PP

>> Rrp40_N  Exosome complex exonuclease Rrp40 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   8.9e-07    0.0053       4      48 .]      31      72 ..      29      72 .. 0.84
   2 ?   -3.6   0.2       1.9   1.1e+04      10      13 ..     123     126 ..     122     126 .. 0.90

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 8.9e-07
     Rrp40_N  4 sssklkLGPGLrhtPplstliatraGiLhtkpkkqalwiEsnskR 48
                +ss +k+G GL+++   s++iat+aG L   p + + ++E+n++R
  EFC38600.1 31 QSSIVKIGHGLLQLE--SNIIATKAGLLRFIPPN-RYFVENNQHR 72
                5566*******9998..69**********88875.5599999998 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.9
     Rrp40_N  10 LGPG 13 
                 LGPG
  EFC38600.1 123 LGPG 126
                 9**9 PP

>> ECR1_N  Exosome complex exonuclease RRP4 N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0    0.0025        15       2      12 ..      12      22 ..      12      27 .. 0.76
   2 ?    4.3   0.0    0.0057        34      15      35 ..      36      56 ..      28      58 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0025
                E-TT-EEEETT CS
      ECR1_N  2 VtPGevlttde 12
                V+PG+v+++ +
  EFC38600.1 12 VLPGDVIGSLD 22
                99*****9643 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.0057
                EE-TTEEEETTEEEESSSEEE CS
      ECR1_N 15 mrGhGTYvrggtiyAsvaGtv 35
                + GhG    +++i+A+ aG +
  EFC38600.1 36 KIGHGLLQLESNIIATKAGLL 56
                679****9***********76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       506  (0.0282224); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.29s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 1701.08
//
Query:       EFC38601.1  [L=377]
Description: hypothetical protein NAEGRDRAFT_56335 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   5.3e-149  496.3   0.0   2.1e-148  494.3   0.0    1.7  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  494.3   0.0  1.2e-152  2.1e-148       2     407 .]       5     377 .]       4     377 .] 0.98

  Alignments for each domain:
  == domain 1  score: 494.3 bits;  conditional E-value: 1.2e-152
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 ++v+a+V+DnGs++++aG+ag+daP+av+ps++g+p++++ +      + yvgdea++kr+ l++++p+e+G+v++wd++e++w+h++++el+v peeh
  EFC38601.1   5 EDVQALVVDNGSGMCKAGFAGDDAPRAVFPSIIGRPKQKSIMVgmgnkDAYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEH 103
                 689************************************998899**9*************************************************** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvev 194
                 p+llte+plnp+++rek+++i+fE+f vpa+y+a +avls++asg++tg+v+DsG++v++ vp+++Gy+L +ai r+dl+G++Lt++l+++l ++    
  EFC38601.1 104 PVLLTEAPLNPKANREKMTQIMFETFSVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILMER---- 198
                 **********************************************************************************************8.... PP

       Actin 195 tprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligs 291
                                           ++s++t++e+e++++iKe++c+++ d+e+  + +++sss eksYeLPDg++i++g+eRf++pE+LF+p+ ig+
  EFC38601.1 199 --------------------------GYSFNTTAEREIVRDIKEKLCYIALDFEAemKVAAESSSVEKSYELPDGNVITVGNERFRCPEVLFQPNFIGM 271
                 ..........................9**************************996666677799********************************** PP

       Actin 292 esaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvs 390
                 e a         g++e ++++i +cd+d+r++L+ n+v++GG+++++g+ eR+ kel+++a++++k+k++ap+ erkys+WiGGSiLAsl+tfqq+w++
  EFC38601.1 272 EAA---------GVHETTFNSIGKCDIDIRKDLYGNVVLSGGTTMFEGIAERMTKELTAMAPASMKIKVVAPP-ERKYSVWIGGSILASLSTFQQMWIT 360
                 *99.........*************************************************************.************************* PP

       Actin 391 kqEYeEqGssvverkck 407
                 k+EYe+ G+ +v+rkc+
  EFC38601.1 361 KEEYEDAGPGIVHRKCF 377
                 ****************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (377 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       349  (0.0194657); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 2652.94
//
Query:       EFC38602.1  [L=441]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.0  24.1      0.016   14.8  12.0    2.9  3  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.8    0.0012        22      64     114 ..      14      64 ..       5      92 .. 0.57
   2 ?   -0.7   0.1     0.048   8.7e+02      68      93 ..     134     157 ..     104     172 .. 0.46
   3 ?   14.8  12.0   9.1e-07     0.016      23     117 ..     292     403 ..     272     427 .. 0.48

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0012
       SR-25  64 sssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekk 114
                 +s+  s ss   +s ss  + ++ ++  + k+++k  k+ k  k+ + +k+
  EFC38602.1  14 NSTPGSTSSNQFNSDSSKFNFVDMTKDVEFKTRNKGDKSLKVNKQFRYNKR 64 
                 344444444444555555555555555555555555555444444444443 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.048
       SR-25  68 sssssssssssssssssssddrkkrg 93 
                 s+s      + ss  s+++++ + rg
  EFC38602.1 134 STST--NPLTESSNNSTTNNQYRVRG 157
                 2222..22222222223333322222 PP

  == domain 3  score: 14.8 bits;  conditional E-value: 9.1e-07
       SR-25  23 sskdssrsssasksqsrkassasekee.........erskekkkkkrrrs...sssssssssssssssssssssssdd...............rkkrgk 94 
                 ss++ +r++sa +   +k + +s +ee         + +   +kk++r+s   +sssssssss  sss ss ++s+++                     
  EFC38602.1 292 SSNTVNRAMSAPTIVFEKVTDQSPNEEdtaiwledkTLKPTINKKRQRKSflfNSSSSSSSSSGVSSSESSVQNSNSNspntlnnngdnllavV----- 385
                 5555666666666666666555555555556663322222223333332212234444444554555555555554445566543333332221..... PP

       SR-25  95 kkdkkkkkkkkkkkkkkekkkak 117
                      +++ kkk ++ + kkk+ 
  EFC38602.1 386 -----TNEVKKKSSSPQYKKKNI 403
                 .....222222222222233322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1476  (0.0823247); expected 358.6 (0.02)
Passed bias filter:                      253  (0.0141112); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2828.09
//
Query:       EFC38603.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.4e-96  323.8  11.5    1.7e-96  323.5  11.5    1.0  1  G-alpha    G-protein alpha subunit
    9.6e-12   44.7   1.0    1.4e-08   34.4   0.2    2.7  2  Arf        ADP-ribosylation factor family
    2.4e-05   23.8   5.4     0.0011   18.3   0.2    2.8  2  Gtr1_RagA  Gtr1/RagA G protein conserved region
     0.0029   17.3   0.1      0.011   15.4   0.0    2.0  2  AAA_29     P-loop containing region of AAA domain
  ------ inclusion threshold ------
      0.015   15.4   1.2        5.1    7.2   0.0    3.1  3  MMR_HSR1   50S ribosome-binding GTPase
      0.041   14.2   0.1       0.12   12.7   0.1    1.8  1  AAA_22     AAA domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  323.5  11.5  5.8e-100   1.7e-96      19     354 .]      11     345 ..       2     345 .. 0.89

  Alignments for each domain:
  == domain 1  score: 323.5 bits;  conditional E-value: 5.8e-100
                 XE..EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH........ CS
     G-alpha  19 kkkrevkllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliaklssate 117
                   +++v+llllG seSGKsT++kq+k+l+++g+s+eel +++  iq+n+v  +  +++a ++l+  + + + +q  +       + +++l++++ +  +
  EFC38603.1  11 AVDNTVNLLLLGISESGKSTLFKQVKILHQNGYSKEELMSFKITIQNNLVLGMAALIDAAQQLNFISPQTITQQGSTTTTTTTTTEDSALYEHIATILK 109
                 33679*********************************************************8766666665555555555555555555544433333 PP

                 .....HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCG.CCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEEEEEE-SS CS
     G-alpha 118 ee...qeiefnpraevgedikaLwndpgiqelyerr.nkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdsklefrivdvgGq 212
                  +   ++  f +      +i+ +w+++ iq+ y +r + +++ dn++yFlddl+ri s +Y+pt dDil++rl+t+G++etkfe++ +l +r+vdvgGq
  EFC38603.1 110 RSssaDTLAFDS--TKLVSIQYVWKHEKIQQAYHQRhSTYQIIDNLNYFLDDLDRIGSSQYVPTIDDILHCRLRTTGVHETKFEFG-GLGMRLVDVGGQ 205
                 333337777777..67779***************8879999*********************************************.************ PP

                 HHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGG.CCTT--H.CCHHHHHHH CS
     G-alpha 213 rserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgklsk.yfpsyegrkndlesvlk 310
                 r++rkkW+++fd+v+a+iF+vsl e++qvl+ed+++ r++es+ lF+e++n++ + ++p++LflnK+D ++e +kk+++s+ +f++y+g+kn++ +++k
  EFC38603.1 206 RNQRKKWIHVFDNVTALIFVVSLVEYNQVLEEDPSTIRMNESMLLFEELVNCSVFYDKPVMLFLNKVDSFNELIKKVDISEtCFKDYSGKKNSAPDAIK 304
                 *****************************************************************************88888***************** PP

                 HHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHHHHHH CS
     G-alpha 311 ylrnkFeeihkeksnnrrkiythftsatdtkevqkviesvrdti 354
                 ++++kF+++ +   n++  ++t +t+a+dt++++kv+e+++ +i
  EFC38603.1 305 FIEQKFKSLRE---NKDADVFTEVTCAIDTNNIRKVLENLKTII 345
                 *********43...67779*********************9886 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0   0.00046       1.4      10      35 ..      11      36 ..       3      56 .. 0.85
   2 !   34.4   0.2   4.8e-12   1.4e-08      45     131 ..     182     278 ..     171     345 .. 0.83

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00046
                T.TTEEEEEEEESTTSSHHHHHHHHH CS
         Arf 10 lkkkelrilllGLDnaGKtTilkklk 35
                 +++ + +lllG+ ++GK+T+ k++k
  EFC38603.1 11 AVDNTVNLLLLGISESGKSTLFKQVK 36
                4578899**************99987 PP

  == domain 2  score: 34.4 bits;  conditional E-value: 4.8e-12
                 SSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT..........THHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS CS
         Arf  45 TigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre..........RleeakeeLkalleeeelkevallvlaNKqDlpeal 131
                 T+g    + e+ +l +++ DvGGq++ R+ W + f++++a+ifvv  ++ +          R++e+   +++l++ +   + +++++ NK D  + l
  EFC38603.1 182 TTGVHETKFEFGGLGMRLVDVGGQRNQRKKWIHVFDNVTALIFVVSLVEYNqvleedpstiRMNESMLLFEELVNCSVFYDKPVMLFLNKVDSFNEL 278
                 7888888999999********************************8776543344455566999999999999999999999**********86654 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.2    0.0013       3.8       2      36 ..      18      56 ..      17      61 .. 0.77
   2 !   18.3   0.2   3.7e-07    0.0011      34     129 ..     182     280 ..     170     310 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0013
   Gtr1_RagA  2 vLLmGksgsGKtsmr...siiFdn.ylardtlrlgatid 36
                +LL+G s+sGK+++    +i+++n y+ ++ ++ ++ti+
  EFC38603.1 18 LLLLGISESGKSTLFkqvKILHQNgYSKEELMSFKITIQ 56
                8************96222577766478888999999987 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 3.7e-07
   Gtr1_RagA  34 tidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDve..........sr.eleedletlkeilealrqyspeakvfvlihKm 121
                 t+ v+++++  +g l + l+D+gGq++  ++       ++f nv +li+V+             s+  ++e++  ++e+++  + y+    v  +++K+
  EFC38603.1 182 TTGVHETKF-EFGGLGMRLVDVGGQRNQRKKW-----IHVFDNVTALIFVVSLVeynqvleedpSTiRMNESMLLFEELVNCSVFYD--KPVMLFLNKV 272
                 445566666.468899*********9987775.....89***********9987566776665533356666666666666655554..4688899999 PP

   Gtr1_RagA 122 Dliqeder 129
                 D  +e  +
  EFC38603.1 273 DSFNELIK 280
                 99876544 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   3.7e-06     0.011      13      39 ..       6      32 ..       2      44 .. 0.78
   2 ?   -2.3   0.0       1.3   3.7e+03      36      45 ..      64      73 ..      53      80 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3.7e-06
      AAA_29 13 dghtieidlkgatlltGpsGsGKSTll 39
                +++t+ +d   + ll G s+sGKSTl+
  EFC38603.1  6 HQNTLAVDNTVNLLLLGISESGKSTLF 32
                446666664449*************97 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.3
      AAA_29 36 STllDAiqal 45
                 +l+DA q l
  EFC38603.1 64 AALIDAAQQL 73
                5789998865 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0    0.0039        12       3      18 ..      19      34 ..      17      59 .. 0.88
   2 ?    7.2   0.0    0.0017       5.1      33     114 .]     182     271 ..      79     271 .. 0.73
   3 ?   -1.6   0.0      0.95   2.9e+03      67      97 ..     307     341 ..     280     349 .. 0.54

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0039
                EEEESTTSSHHHHHHH CS
    MMR_HSR1  3 aivGrpNvGKStLina 18
                +++G + +GKStL+++
  EFC38603.1 19 LLLGISESGKSTLFKQ 34
                789**********986 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0017
                 SSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT......TTCSHHHHHHHHHHHHH.............TTSEEEEE CS
    MMR_HSR1  33 TrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas......eeklkpldeeleellee.............akkplilv 111
                 T+ + e +++++g  ++lvD+ G         + +k++  + + + ++++vv++       e     +d +  +++e+              +kp++l 
  EFC38603.1 182 TTGVHETKFEFGGLGMRLVDVGG-QR------NQRKKWIHVFDnVTALIFVVSLVeynqvlE-----EDPSTIRMNESmllfeelvncsvfYDKPVMLF 268
                 5566666677777889*******.43......233333333332678888888773322221.....22222222222333444566666677777777 PP

                 EES CS
    MMR_HSR1 112 lnk 114
                 lnk
  EFC38603.1 269 LNK 271
                 766 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.95
                 HHHHHHHHC...TSEEEEEEETT..TTCSHHHHHHH CS
    MMR_HSR1  67 gkaflalee...adlillvvdas..eeklkpldeel 97 
                 +++f++l+e   ad++  v   +  +++++++ e+l
  EFC38603.1 307 EQKFKSLREnkdADVFTEVTC-AidTNNIRKVLENL 341
                 444554333323666555543.21222344444444 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1     4e-05      0.12       8     103 ..      18     157 ..      13     186 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4e-05
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaee................................erpevv......fvtlpsstsskdllrellralglel 68 
                 l++ G s +GK+tl ++++  +++ ++ ee                                     +      + t +  t+ + l+++++ +l+++ 
  EFC38603.1  18 LLLLGISESGKSTLFKQVKILHQNGYSKEElmsfkitiqnnlvlgmaalidaaqqlnfispqT----ItqqgstTTTTTTTTEDSALYEHIATILKRSS 112
                 78999******************9999999***********************9999955440....34455425555555577899*********999 PP

      AAA_22  69 ka........erlsseell..ealeqalraravielliiDEaqh.l 103
                 +a        +  s + ++  e+++qa ++r+     iiD+  + l
  EFC38603.1 113 SAdtlafdstKLVSIQYVWkhEKIQQAYHQRHS-TYQIIDNLNYfL 157
                 999999999988888888875566777777777.888888888733 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       922  (0.0514251); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2037.18
//
Query:       EFC38604.1  [L=626]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (626 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       582  (0.0324614); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 3731.01
//
Query:       EFC38605.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.3e-47  158.6   0.9    1.4e-46  158.0   0.9    1.3  1  Ribosomal_S8e  Ribosomal protein S8e


Domain annotation for each model (and alignments):
>> Ribosomal_S8e  Ribosomal protein S8e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.0   0.9     8e-51   1.4e-46      11     137 .]       3     224 ..       1     224 [. 0.98

  Alignments for each domain:
  == domain 1  score: 158.0 bits;  conditional E-value: 8e-51
                    EESSTEEXXXSSXXX....................................................CCSBXXXXXXXEE...........SSHEE CS
  Ribosomal_S8e  11 rkltGgkakllrkkr....................................................kielgrkekatkl...........gaerv 43 
                     kl+G+kakl++kkr                                                    +++++rkeka+k+           ++e++
     EFC38605.1   3 TKLRGIKAKLFSKKRhaekvqmqkqireheqknkeertpsedivhggavpsylmdregvshakilsnTLKQKRKEKAGKWavpvpkvralnEDEMF 98 
                    689*****************************************************************************999999987755**** PP

                    EEEEETTCEEEE..............................EEESESEEEEEETTTTEEEEEEEEEEECSSSTCHHHHTTC--TTEEEEEESHHH CS
  Ribosomal_S8e  44 kvvrvrgGkrkk..............................ralrlkkanvthpeekvtkklkIlgVkknpsnneyvrlgvltKgaiievdvseL 109
                    k v  r+Gkrk+                              +alr++kanvthpe+k+t++l+IlgVkknp++ +y++lgv+tKg+++ev+vs+L
     EFC38605.1  99 KIV--RSGKRKRqmykrminkvsyvgedftrkppkferfirpMALRFTKANVTHPELKATFQLPILGVKKNPQSYMYTTLGVITKGTVLEVNVSDL 192
                    ***..******************************************************************************************* PP

                    HHHHHTTEEE....EEEESEHHHHSSEEEEEE CS
  Ribosomal_S8e 110 gevtqsgkvv....AqvtsrPgqdGcvnavlL 137
                    g+v ++gkvv    Aqvt++P++dGc+navlL
     EFC38605.1 193 GLVAPNGKVVwgkyAQVTNNPENDGCINAVLL 224
                    *******************************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1127  (0.0628591); expected 358.6 (0.02)
Passed bias filter:                      593  (0.0330749); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 1456.78
//
Query:       EFC38606.1  [L=261]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.8e-24   84.3   5.7    1.7e-13   50.5   1.3    2.5  2  Myb_DNA-binding  Myb-like DNA-binding domain
    2.9e-20   72.3   9.1    9.9e-14   51.3   3.8    2.4  2  Myb_DNA-bind_6   Myb-like DNA-binding domain
     0.0025   17.8   0.4     0.0054   16.7   0.4    1.6  1  PhaP_Bmeg        Polyhydroxyalkanoic acid inclusion protein (
  ------ inclusion threshold ------
       0.15   12.3   0.2       0.15   12.3   0.2    2.0  3  DUF722           Protein of unknown function (DUF722)


Domain annotation for each model (and alignments):
>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.5   1.3   3.9e-17   1.7e-13       2      46 .]       9      54 ..       8      54 .. 0.97
   2 !   35.7   0.2   1.6e-12   7.1e-09       2      45 ..      61     103 ..      60     104 .. 0.93

  Alignments for each domain:
  == domain 1  score: 50.5 bits;  conditional E-value: 3.9e-17
                     SSSBHHHHHHHHHHHHHHT.TCHHHHHHHHTSS-HHHHHHHHHHHT CS
  Myb_DNA-binding  2 gkWteeEdelLleavkkhG.nrWkkIaerlggRtekqcrsrwrnyl 46
                     g+W   Ede+L  av k+G n+W+++a+ l+ +++kqc+ rw+ +l
       EFC38606.1  9 GPWKNSEDEILKAAVMKYGkNQWARVASLLNRKSAKQCKARWYEWL 54
                     89*****************999*********************997 PP

  == domain 2  score: 35.7 bits;  conditional E-value: 1.6e-12
                      SSSBHHHHHHHHHHHHHHTTCHHHHHHHHTSS-HHHHHHHHHHH CS
  Myb_DNA-binding   2 gkWteeEdelLleavkkhGnrWkkIaerlggRtekqcrsrwrny 45 
                       +Wt eE+e+Ll + k + ++Wk+Ia  + gRt+ qc +++ ++
       EFC38606.1  61 TEWTREEEEKLLHLAKIMPSQWKSIAPIV-GRTASQCLEHYEQM 103
                      68***************************.6*********9876 PP

>> Myb_DNA-bind_6  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.3   3.8   2.2e-17   9.9e-14       1      60 []      11      71 ..      11      71 .. 0.96
   2 !   31.2   0.2   4.2e-11   1.9e-07       1      46 [.      63     107 ..      63     121 .. 0.92

  Alignments for each domain:
  == domain 1  score: 51.3 bits;  conditional E-value: 2.2e-17
  Myb_DNA-bind_6  1 WteeEdeiLlklvekyg.ndWknIaealnrRtpkqcfdrwknkLrpkisrkkwskeedirL 60
                    W   EdeiL   v+kyg n+W  +a+ lnr+++kqc+ rw + L+p+i++++w++ee+++L
      EFC38606.1 11 WKNSEDEILKAAVMKYGkNQWARVASLLNRKSAKQCKARWYEWLDPSIKKTEWTREEEEKL 71
                    9999************9569**************************************997 PP

  == domain 2  score: 31.2 bits;  conditional E-value: 4.2e-11
  Myb_DNA-bind_6   1 WteeEdeiLlklvekygndWknIaealnrRtpkqcfdrwknkLrpk 46 
                     Wt eE+e+Ll l + + ++Wk+Ia + + Rt++qc ++++++L+ +
      EFC38606.1  63 WTREEEEKLLHLAKIMPSQWKSIAPIVG-RTASQCLEHYEQMLDEE 107
                     ****************************.************99755 PP

>> PhaP_Bmeg  Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.4   1.2e-06    0.0054      91     143 ..      61     113 ..      32     120 .. 0.92

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.2e-06
   PhaP_Bmeg  91 eEwtdkleevsakleklalspsKssldllkkaeeqleetvkslieqqkkrRee 143
                  Ewt   ee + +l k+  s+ Ks   ++ ++ +q  e  ++++++++++ e+
  EFC38606.1  61 TEWTREEEEKLLHLAKIMPSQWKSIAPIVGRTASQCLEHYEQMLDEEQRKQEG 113
                 6*******************************************998877664 PP

>> DUF722  Protein of unknown function (DUF722)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.2   3.3e-05      0.15      84     122 ..      13      52 ..       9      60 .. 0.90
   2 ?   -2.9   0.0       1.6   7.4e+03     111     121 ..      91     101 ..      66     111 .. 0.56
   3 ?   -2.1   0.1      0.96   4.3e+03      47      57 ..     169     179 ..     142     212 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 3.3e-05
      DUF722  84 eeekeiiklrykgrrglsWyrvaiel.eisekkakkiyis 122
                 ++e ei+k+   ++++  W rva  l  +s k++k  +++
  EFC38606.1  13 NSEDEILKAAVMKYGKNQWARVASLLnRKSAKQCKARWYE 52 
                 6799**********************88999****98876 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.6
      DUF722 111 isekkakkiyi 121
                    +++ ++y 
  EFC38606.1  91 RTASQCLEHYE 101
                 44444433333 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.96
      DUF722  47 kesrvldkell 57 
                 k++r l +++l
  EFC38606.1 169 KAKRHLREKQL 179
                 33333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1331  (0.0742373); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1646.62
//
Query:       EFC38607.1  [L=664]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-31  109.1   2.3    2.2e-09   37.6   0.1    4.5  4  CBS       CBS domain
  ------ inclusion threshold ------
       0.11   12.8   1.2        6.5    6.9   0.1    2.4  2  Imm5      Immunity protein Imm5


Domain annotation for each model (and alignments):
>> CBS  CBS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   2.2e-05       0.2       8      56 ..     368     417 ..     361     418 .. 0.83
   2 !   31.9   0.0   1.5e-11   1.3e-07       8      56 ..     449     497 ..     436     498 .. 0.91
   3 !   23.9   0.0   4.7e-09   4.2e-05       7      55 ..     520     568 ..     513     570 .. 0.93
   4 !   37.6   0.1   2.4e-13   2.2e-09       7      56 ..     589     638 ..     579     639 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 2.2e-05
                 SCEEEETTSBHHHHHHHHHHHTSSEEEEEETTTB.EEEEEEHHHHHHHHH CS
         CBS   8 dvvtvppdttleealelmrekgvsrlPVVdedgk.lvGivtlrDllrall 56 
                 +v++++ d +++ea++  +++++s     d+++  lvG++t +Dl++ ll
  EFC38607.1 368 KVIVFDIDLPVREAFQVAANNDISFASLWDSEKScLVGMLTVTDLIDILL 417
                 68999************97777*55569986665788*********9875 PP

  == domain 2  score: 31.9 bits;  conditional E-value: 1.5e-11
                 SCEEEETTSBHHHHHHHHHHHTSSEEEEEETTTBEEEEEEHHHHHHHHH CS
         CBS   8 dvvtvppdttleealelmrekgvsrlPVVdedgklvGivtlrDllrall 56 
                 ++++v+p++tl  a+ ++ ++ ++rlPV+   g l++i+t ++ll +l+
  EFC38607.1 449 KLIFVTPEDTLLTAIHTLSKYSIHRLPVLSPKGALLHIITHSHLLAYLV 497
                 789***************8888*******77999************986 PP

  == domain 3  score: 23.9 bits;  conditional E-value: 4.7e-09
                 SSCEEEETTSBHHHHHHHHHHHTSSEEEEEETTTBEEEEEEHHHHHHHH CS
         CBS   7 rdvvtvppdttleealelmrekgvsrlPVVdedgklvGivtlrDllral 55 
                 ++vvt++ ++ l  a+ ++++++vs++PVV+edg +v ++++ D++ ++
  EFC38607.1 520 TNVVTAKMEMQLFAAVCMFAKYKVSAIPVVNEDGCVVDVFSRYDIVYFV 568
                 699****************9999***********888********9775 PP

  == domain 4  score: 37.6 bits;  conditional E-value: 2.4e-13
                 SSCEEEETTSBHHHHHHHHHHHTSSEEEE.EETTTBEEEEEEHHHHHHHHH CS
         CBS   7 rdvvtvppdttleealelmrekgvsrlPV.VdedgklvGivtlrDllrall 56 
                  +v+t++  ++ e++l+ +  ++++rl V Vde+ ++vGiv+ +D++++l+
  EFC38607.1 589 IPVFTCTKAESFEKVLRHLSTTRIHRL-VcVDEYSRVVGIVSISDIFSFLM 638
                 3899***************7777****.989******************97 PP

>> Imm5  Immunity protein Imm5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.1    0.0049        44      49      83 ..      81     115 ..      75     135 .. 0.76
   2 ?    6.9   0.1   0.00073       6.5      53     141 ..     207     298 ..     172     308 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.0049
        Imm5  49 weevfaedqsplrlLekaedylyektdkeeiekea 83 
                 ++  ++++q++ r+L+k+ + l++k+d++++ k+ 
  EFC38607.1  81 NNIFIKKNQKLRRILSKVHNLLFKKQDEKQLFKQL 115
                 5667899*****************88888776654 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.00073
        Imm5  53 faedqsplrlLe..kaedylyektdkeeiekeadklsndlendsgeeaeetvalaglaAlkvivtliysietdaesilee.ddyldedd..fDp 141
                 f+++++ +++ +  k ++  +  t   ++ +++ +l+n ++++s+++++++ +++g +  + i + i +i++  ++i+++  + ++edd  +D 
  EFC38607.1 207 FPNSNKQMGCTNfqKKQKKYFTPTRSLSLPSITRSLDNNIKDHSYNNKNNNLSVIGKSETSSIQQKINNIKS--STIMNIpKKNTSEDDfsMDE 298
                 5666666655431133344444667777888999999*****99***********************88877..66775414455566534444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (664 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1206  (0.0672653); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 3763.27
//
Query:       EFC38608.1  [L=575]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   2.4e-104  349.9  44.9     3e-104  349.6  44.9    1.0  1  Rft-1            Rft protein


Domain annotation for each model (and alignments):
>> Rft-1  Rft protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  349.6  44.9  1.7e-108    3e-104       4     508 ..      43     558 ..      40     560 .. 0.93

  Alignments for each domain:
  == domain 1  score: 349.6 bits;  conditional E-value: 1.7e-108
       Rft-1   4 kgatflillQlisrlitFllNqllvrflsprilGitvrLelllstiLFlSREairlavlriksk.kkkseslqkvvnlalipvligivlsivli.lwqy 100
                 kg+++l+ l ++s+++tF+ N++++r+l+p   G   + el+ +t++FlS E +r+a+lr++ + +++++++qk+  ++l++++ g++  i++  +w  
  EFC38608.1  43 KGLSYLLSLSFLSKIVTFVANTYIIRQLDPGTKGFIFKSELFATTVIFLSSECFRRACLRTNLNeSNNENQYQKIRTISLLSIPYGLLTMIFCYfIWG- 140
                 89**********************************************************99995677899***************999999886666. PP

       Rft-1 101 slsneellqlpyfklsvllvalsiiiellseplyvvaqaelnvklrskleslavlvrclvtfaiivlfekeakegiailaFalgqlaysltllllyyvd 199
                    + +l +++     +l++ ++++ie++++p+y+++ a+l +++r+++e+ a++++ + +f+i+ +++ e+     +l F ++q+ yslt+++ y+++
  EFC38608.1 141 ---TFYLPKVDSTISPLLIYSFATFIEIFAQPMYILSLAQLAFGVRVTIEASALFIKIISSFFIVNICKTEN----VLLYFGYSQICYSLTIFIGYLIY 232
                 ...6667777777777999*************************************************9998....59*******************99 PP

       Rft-1 200 flknlkkkkkfslkltkiklkeekksyyfdkdllelfkkvffqlilKhlLteGdkliisllctveeQGiYalvsnyGSLvaRlvfaPiEEslrlffakl 298
                  +k ++ +k     l+k        ++ +d +l+el+ ++ +q+++K++LteG+k i+ l+ t ++QG+Y++v n+GSL+aRl+f+ +EE++  + +kl
  EFC38608.1 233 NFKWNNGNKL----LEKF-------TISWDWNLFELSQSFLYQSVIKYILTEGEKHILILFRTQYDQGVYDIVFNLGSLAARLIFQYLEETSFSIWSKL 320
                 9666554433....3333.......35799********************************************************************* PP

       Rft-1 299 l..........sskkskknlkesvevLlnllklylylsllivifGpsyssflLqlliGskwsst.svldllrvYclyipllalNGilEaFvqsvassaq 386
                            s+++ ++++ +s +vL++ lk+ ++++++  +fGp+ys++l+ ll+G +w+++ +++++l++Yc+yi ++alNGi+EaF+++  + ++
  EFC38608.1 321 SnivncterkpSNDEITESVTTSATVLILFLKASILIGCVFAFFGPAYSHTLIYLLYGDQWANNtEAPQILSIYCFYIFFMALNGISEAFIHALSDRKE 419
                 9999**99999899999********************************************98758999****************************** PP

       Rft-1 387 llkqsylmvvfSvvfllasyllievlklgaeGlilaNivNmllRiiyslrfikkfykklkle......kslrellpsalvvalllvsliigyv...... 473
                 + k +y+m++fS+v++ +++ ++  ++lg + +i+aN++Nml+Ri ys++fi  f+kk+k +      + l++++ps++v+++l+ +l+i+        
  EFC38608.1 420 IIKLNYIMILFSIVYMSVCITCLWLFNLGTKSMIIANCFNMLMRISYSTYFIVLFFKKHKNNlrmkpsEILQQIIPSKVVLIVLSSCLVITKAtelyfd 518
                 ************************************************************999**9988999************9999999989****9 PP

       Rft-1 474 .....velsknllqlligillalllllaillkerellkel 508
                       +    ++++++g l+++l+++ ++  e+ +++++
  EFC38608.1 519 isktkLFCIVRFVHIGVGSLFLMLFIVCLYKFEKPFIRQF 558
                 9988766778999999999999999999999999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (575 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       841  (0.0469072); expected 358.6 (0.02)
Passed bias filter:                      259  (0.0144459); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 3326.83
//
Query:       EFC38609.1  [L=489]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.5e-41  142.0   0.0    5.5e-41  140.8   0.0    1.5  1  tRNA-synt_His   Histidyl-tRNA synthetase
    3.3e-08   33.7   0.0    8.7e-08   32.3   0.0    1.6  1  tRNA-synt_2b    tRNA synthetase class II core domain (G, H, P
    7.1e-06   26.1   0.2    2.2e-05   24.5   0.0    1.9  2  HGTP_anticodon  Anticodon binding domain
  ------ inclusion threshold ------
      0.011   15.2   0.0      0.028   13.9   0.0    1.7  1  tRNA-synt_2d    tRNA synthetases class II core domain (F)


Domain annotation for each model (and alignments):
>> tRNA-synt_His  Histidyl-tRNA synthetase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  140.8   0.0   1.2e-44   5.5e-41       1     304 [.      46     375 ..      46     377 .. 0.82

  Alignments for each domain:
  == domain 1  score: 140.8 bits;  conditional E-value: 1.2e-44
                    T---EETCHHHHHHHHHHHHHHHHHHTT-EEEE--SEEEHHHHCTTSTCCHH.HS-EEE-TTSSEEEE-SSSHHHHHHHHHHHHH.TSS-EEEEEE CS
  tRNA-synt_His   1 glrdllpeeaekieelrrrlldlfeswGYelVspPllEyldslltgagedld.qtfklvDqsgrllglRaDiTpqvaRiaahrln.rerplRlcYa 94 
                    g+rd+lpee++++e+l ++++++ +  G+e+   P+lE+++ + +++ge+   q++ ++D+s+ +++lR+++Tp+ aR+  ++ +  + pl+++++
     EFC38609.1  46 GTRDFLPEEMREREWLFSKFHETSKLFGFEPYDAPILEMEELYKRKGGEEIVqQMYNFIDKSELNVALRPEMTPSLARLILKNKKtLKFPLKWYSI 141
                    78**********************************************996549*****************************999********** PP

                    EEEEESS-SSTT--CCEEEEEEEEESS-SHHHHHHHHHHHHHHHHHHCTS..SSEEEEEEETCHHHHHHH...HTT--HHHHHHHHHHHHCT-... CS
  tRNA-synt_His  95 GsvlrtrpdglgrsreplQvGaEliGaegleadlEvlslllealeaaagv..kelrldlghvglvralle...aaglsesleeallaalarkd... 182
                     +++r +++  gr+re +Q  + + G++++  + E+   +++ ++ ++++  +++++ +++ ++++ l++    ++ls+++ ++   ++++ d   
     EFC38609.1 142 PQCWRYETTTRGRKREHYQWNCDIWGVQDVTGECELFATIVNFFK-LVSLssEKVTIRFSSRKIIEDLIKlefGLNLSDDKFKETCIIIDKMDkme 236
                    ********************************************7.8664449***************9874567788888888776666666111 PP

                    HHHHHHHHHCCTTH............HHCCHCC......HCCHCCCHHHHCHCCHCTHHHHHH..HHHHHHHHHHHHHHHHH.H-TTEEE-TT--T CS
  tRNA-synt_His 183 laelkelaaeaglk............ealrellkal...elygdaevleealealaaapalqa..aldeleelaallealak.pevrvtlDlaelr 260
                    ++++k+++ + +++               +++ k+l   e y++ ++le+  + + +++a+++  + +e+ee+ a++ + ++  e  + +D++ +r
     EFC38609.1 237 AEDVKKILVD-KVPeisdevalkiikL--MNF-KKLnpnEDYSGSKALEAF-KGMLTNQAFKDstVFKEVEEIFAMVGKNGYdIEDWIEFDPSIVR 327
                    5555555554.3447777776665331..222.222243445555666665.445555555442378999*******9999888999********* PP

                    TTTT--SEEEEEEETT..-SS-SEEEEEECTTTGGG..T---EEEEEE CS
  tRNA-synt_His 261 gyeYytGlvFaayaeg..vgqaiarGGrYdelgaaf..grarpAtGfs 304
                    g++YytG+vF+a+a     ++ai +GGrYd++++ +  + + pA+Gf 
     EFC38609.1 328 GLSYYTGVVFEAFATVgdIQRAICGGGRYDKILGTYgaKDQIPACGFG 375
                    *************97322667***************544699*****6 PP

>> tRNA-synt_2b  tRNA synthetase class II core domain (G, H, P, S and T)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.3   0.0   1.9e-11   8.7e-08       1     110 [.     101     272 ..     101     349 .. 0.70

  Alignments for each domain:
  == domain 1  score: 32.3 bits;  conditional E-value: 1.9e-11
                   EEEEETTSEEEEE-SSSHHHHHHHHHHHEEEBGGSSEEEEEEEEEEBTTTSTBCTTTB-SEEEEEEEEEEESGGGHHHHHHHHHHHHHHHHHHTT.S CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  tRNA-synt_2b   1 YkledrndreyiLkPtneetfvelirdevlrskrLPlklyqiqtkyRdEksdsrGLlRvreFhqkdgyvfhaeaslddslrdlikaisriferlgle 97 
                   Y + d+ + + +L+P+ ++ +++li ++  +  + Plk y i  ++R+E+  +rG  R re  q ++ + + ++       +l+ +i ++f+ + l+
    EFC38609.1 101 YNFIDKSELNVALRPEMTPSLARLILKN-KKTLKFPLKWYSIPQCWRYETT-TRG--RKREHYQWNCDIWGVQD--VTGECELFATIVNFFKLVSLS 191
                   889999999*****************99.66666*****************.***..**************998..455567888888888888775 PP

                   C.EEEEEEGTTSC....................................................................B CS
                   x.xxxxxxxxxxx....................................................................x RF
  tRNA-synt_2b  98 f.raiielmsaks....................................................................a 110
                     +++i+  s+ +                                                                     
    EFC38609.1 192 SeKVTIRFSSR-KiiedliklefglnlsddkfketciiidkmdkmeaedvkkilvdkvpeisdevalkiiklmnfkklnpnE 272
                   52333333322.2233444455566666666666666655555555555555555555555555555555555555555551 PP

>> HGTP_anticodon  Anticodon binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1         1   4.6e+03      49      83 ..     207     241 ..     202     248 .. 0.76
   2 !   24.5   0.0   4.9e-09   2.2e-05       3      86 ..     403     488 ..     402     489 .] 0.86

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1
                     HHTT-SEEEEE-HHHHHHTEEEEEETTTCEEEEEE CS
  HGTP_anticodon  49 dllgipfavvvGekelekgtvtvrdrdtreqervs 83 
                     dl++  f + + ++ +++  + + ++d++e e v+
      EFC38609.1 207 DLIKLEFGLNLSDDKFKETCIIIDKMDKMEAEDVK 241
                     67777777888888887777778888888887765 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 4.9e-09
                     EEEESSSSHHHHHHHHHHHHHHHHTTTSEEEEES.SSSTHHHHHHHHHHTT-SEEEEE-HHHHHHTEEEEEET...TTCEE..EEEETTH CS
  HGTP_anticodon   3 vviplnekaeeleeyakklaeeLraagirveldd.snesigkkireadllgipfavvvGekelekgtvtvrdr...dtreq..ervslde 86 
                     +vip+      l + a k+ + Lr++g  ++l+  + +++g  +++ad++g   a++v + e ++g+v+++ +   d  e+   +v++++
      EFC38609.1 403 FVIPFDL---SLRPQAAKIVSILRKKGRVADLYLkNPKKVGACFEYADKIGATRAIFVAPAEWNNGQVKIKMLreeDP-EKkeFTVKIED 488
                     5889998...899**************99*****999**********************************9965422.33124777776 PP

>> tRNA-synt_2d  tRNA synthetases class II core domain (F)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   6.2e-06     0.028      76     150 ..      96     186 ..      54     204 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 6.2e-06
                   -..........ECESEEE-SSTHHHHHHHH....TTS-SSEEEEEEEEEEBSST-SSSB-SEEEEEEE..EEEETT--HHHHHHHHHHHHH CS
  tRNA-synt_2d  76 a..........veekllLRthttavqirtl....ekkkppikiisigrvfRrdavDathlaeFhqveg..lvvdenvsladlkgvleellk 150
                   +           e ++ LR  +t+  +r +    ++ k p+k  si +++R +++ + ++ e +q ++  + v++     +l +++ +++k
    EFC38609.1  96 IvqqmynfidkSELNVALRPEMTPSLARLIlknkKTLKFPLKWYSIPQCWRYETTTRGRKREHYQWNCdiWGVQDVTGECELFATIVNFFK 186
                   34444444444567899***********99876666679****************999999999977621334444445567777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 2910.15
//
Query:       EFC38610.1  [L=387]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0018   19.1   0.1        3.8    8.4   0.0    2.5  2  EF-hand_11  EF-hand domain
     0.0019   17.6   0.4      0.036   13.6   0.3    2.8  2  EF-hand_1   EF hand
     0.0064   16.9   0.3      0.017   15.6   0.3    1.8  1  DUF5582     Family of unknown function (DUF5582)
     0.0086   15.9   0.4      0.063   13.1   0.0    2.7  3  EF-hand_8   EF-hand domain pair
  ------ inclusion threshold ------
      0.012   16.1   0.4       0.32   11.5   0.1    2.7  2  EF-hand_7   EF-hand domain pair
      0.019   14.1   0.7      0.029   13.5   0.7    1.2  1  DUF5586     Family of unknown function (DUF5586)
      0.071   13.1   0.5       0.46   10.5   0.1    2.6  3  EF-hand_6   EF-hand domain


Domain annotation for each model (and alignments):
>> EF-hand_11  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0    0.0018       4.6      49      86 ..     309     346 ..     298     360 .. 0.82
   2 !    8.4   0.0    0.0015       3.8      33      56 ..     361     384 ..     353     387 .] 0.89

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0018
                 HT----HHHHHHHHHTS-B-TTS-EEHHHHHHHHCS-. CS
  EF-hand_11  49 rvqiltdeqfdrlwselpvnakgrlkyqdflsklsier 86 
                  ++ilt  +f+ +++ + +n kg + y++ l  +   +
  EFC38610.1 309 SLKILTPTDFETMFTMIDINNKGFVTYEQTLKTMVNLK 346
                 589*************************9998776554 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0015
                 -SSEE-HHHHHHHHHHHT----HH CS
  EF-hand_11  33 ksntvsreefraictrrvqiltde 56 
                 k+  +s+e+f  i+tr+++il+d 
  EFC38610.1 361 KAARISKEQFVKIVTRHLDILSDT 384
                 7789*****************997 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.3   1.4e-05     0.036       1      20 [.     317     336 ..     317     337 .. 0.92
   2 ?    0.4   0.0      0.23   5.8e+02      16      28 ..     364     376 ..     360     377 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.4e-05
                 HHHHHHHHHTTTSSSEEEHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfe 20 
                 +++ +F ++D ++ G++++e
  EFC38610.1 317 DFETMFTMIDINNKGFVTYE 336
                 5889**************98 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.23
                 EEEHHHHHHHHHH CS
   EF-hand_1  16 kIdfeEfkellkk 28 
                 +I++e+f++++++
  EFC38610.1 364 RISKEQFVKIVTR 376
                 59*******9986 PP

>> DUF5582  Family of unknown function (DUF5582)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.3   6.6e-06     0.017     107     144 ..     262     299 ..     230     303 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 6.6e-06
     DUF5582 107 yqvsLrymekhhiLqifqqitenLvyekPedPLsfmLs 144
                  q +  ym kh+i +++q + ++   ++PedP +f+++
  EFC38610.1 262 KQTARDYMKKHKISELLQYLLQQTLINMPEDPRKFLIE 299
                 477889*****************************976 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       2.7   6.9e+03       8      18 ..     238     249 ..     237     255 .. 0.69
   2 !   13.1   0.0   2.5e-05     0.063      19      49 ..     311     339 ..     298     345 .. 0.77
   3 ?   -1.9   0.0       1.2   3.2e+03       4      15 ..     364     376 ..     362     380 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.7
   EF-hand_8   8 eelrrilril.g 18 
                 ++lrr++++l g
  EFC38610.1 238 ADLRRMINSLeG 249
                 799998876633 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 2.5e-05
   EF-hand_8  19 lkkglseeevdilfrefDtdgdGkisfeEFc 49 
                 +   l++ +++++f  +D++++G +++e ++
  EFC38610.1 311 KI--LTPTDFETMFTMIDINNKGFVTYEQTL 339
                 33..9*********************98665 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.2
   EF-hand_8   4 kItreelrril.r 15 
                  I++e +++i+ r
  EFC38610.1 364 RISKEQFVKIVtR 376
                 6999999999855 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   0.00013      0.32      35      67 ..     305     339 ..     235     343 .. 0.76
   2 ?   10.6   0.0   0.00023      0.59       4      30 ..     318     344 ..     315     381 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00013
   EF-hand_7  35 a..gegsklsdeelellfkefDtdkdGvisfdEFl 67 
                 +  +  + l+++  e++f ++D ++ G ++++  l
  EFC38610.1 305 KkkSSLKILTPTDFETMFTMIDINNKGFVTYEQTL 339
                 14455566677888999999999999999988655 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00023
   EF-hand_7   4 lkeaFkelDtdgdgyldkeellrllrk 30 
                  +++F ++D ++ g++++e+ l+ + +
  EFC38610.1 318 FETMFTMIDINNKGFVTYEQTLKTMVN 344
                 578999999999999999996655444 PP

>> DUF5586  Family of unknown function (DUF5586)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.7   1.1e-05     0.029       5      46 ..     266     308 ..     262     315 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.1e-05
     DUF5586   5 qsyleknkigplfeelmtklitetpdhpipflidhlqt.kqes 46 
                 + y++k+ki+ l++ l+ + + + p++p  fli+ lq  k++s
  EFC38610.1 266 RDYMKKHKISELLQYLLQQTLINMPEDPRKFLIENLQQiKKKS 308
                 5799********************************8624444 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       6.1   1.6e+04      19      27 ..      81      89 ..      79      91 .. 0.71
   2 ?   10.5   0.1   0.00018      0.46       2      24 ..     318     340 ..     317     345 .. 0.85
   3 ?   -2.0   0.0       1.8   4.7e+03      17      27 ..     365     375 ..     364     379 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 6.1
   EF-hand_6 19 aeElrkalr 27
                 +E+ + +r
  EFC38610.1 81 GNEFLDQFR 89
                678888777 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00018
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrk 24 
                 ++  F ++D ++ G++++e+  k
  EFC38610.1 318 FETMFTMIDINNKGFVTYEQTLK 340
                 7889*************998655 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1.8
   EF-hand_6  17 idaeElrkalr 27 
                 i++e+++k+ +
  EFC38610.1 365 ISKEQFVKIVT 375
                 999***99977 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (387 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1022  (0.0570026); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.36s 00:00:01.01 Elapsed: 00:00:00.57
# Mc/sec: 2055.59
//
Query:       EFC38611.1  [L=249]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.9e-19   67.8   0.0    4.7e-18   65.4   0.0    2.0  1  Macro     Macro domain
  ------ inclusion threshold ------
      0.061   13.7   0.2        0.1   13.0   0.2    1.4  1  FRB_dom   FKBP12-rapamycin binding domain


Domain annotation for each model (and alignments):
>> Macro  Macro domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.4   0.0   5.2e-22   4.7e-18       1     117 [.     107     243 ..     107     244 .. 0.83

  Alignments for each domain:
  == domain 1  score: 65.4 bits;  conditional E-value: 5.2e-22
                 EEEEETTSS-CSHHHHHHHHHHHHHHHHHH.HHHHH.HHHS.........--TTSEEEEE-TTSS....SSEEEEEESE-TTTS.TSTTHHHHHHHHHH CS
       Macro   1 VnAaNsrllggggvagaihraagkalkeec.kelek.kqgg.........cllGeavvtpaynlp....akyvihtvgplftss.kskeeeellakayk 83 
                 Vn+ N+ l  ggg a +i + +g    e++  + ++ k+++         c++Ge++vt++++++    ++y+iht gp+ +++ ++ ++  lla++y+
  EFC38611.1 107 VNPSNEALVIGGGLASVIFQCCGRCEMENSlADPSQwKYKSfevnekeihCPVGEILVTSSFKMQesngFNYIIHTSGPRGSQKyGDATNSLLLANCYR 205
                 9*********************9544443323322202222555566777*******************************9987888888899***** PP

                 HHHHH....HHHTT-SEEEEE-TTSSTTSBTHHHHHHH CS
       Macro  84 nalel....aeekgiksvafPaistGifgvpweeaarv 117
                 n+l+     a++ ++ ++ +P+istG fg+p+ ea  +
  EFC38611.1 206 NSLRFfidnARNTKASTLILPCISTGKFGYPKIEASAI 243
                 ***9988889999999****************999876 PP

>> FRB_dom  FKBP12-rapamycin binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   1.2e-05       0.1      10      89 ..       2      83 ..       1      93 [. 0.80

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
     FRB_dom 10 hElwhegLeeAsrlyfgeknveamlklleplhellekgpetlreasFaqafgreLkeae.....ewlkkykkteneedlnqawdi 89
                 E w++ L +  + + ++k+  ++lk+++p + + +   e + +++F++++g++L+e       +++k+y+ t  + + n++w++
  EFC38611.1  2 DESWYQDLMQ-LESWSDRKKLVQVLKTIQPQMYNSRL--EIAFDSNFTSEHGSSLEELLsslnlDYCKQYSTTIGNINWNDLWSC 83
                5999999955.55688888889999999997666555..99**************997522223789999999999999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (249 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       602  (0.0335769); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.38
# Mc/sec: 1955.43
//
Query:       EFC38612.1  [L=552]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-13   50.3   0.2    1.7e-05   25.2   0.0    2.8  2  AAA              ATPase family associated with various cellul
      7e-11   42.8   0.5     0.0003   21.2   0.0    3.0  3  AAA_16           AAA ATPase domain
    7.8e-07   29.7   1.2      0.011   16.3   0.0    3.0  2  AAA_18           AAA domain
    7.9e-07   29.4   2.7      0.058   13.7   0.1    3.5  3  AAA_22           AAA domain
      2e-05   23.9   0.2     0.0043   16.2   0.0    2.8  3  DUF815           Protein of unknown function (DUF815)
    2.5e-05   24.3   1.2      0.078   13.0   0.1    3.1  2  AAA_5            AAA domain (dynein-related subfamily)
    5.1e-05   23.8   0.4       0.21   12.1   0.0    2.6  2  ABC_tran         ABC transporter
    5.7e-05   23.4   0.9       0.22   11.9   0.1    3.3  2  RNA_helicase     RNA helicase
    0.00015   21.6   0.7          1    9.1   0.1    3.2  2  IstB_IS21        IstB-like ATP binding protein
    0.00017   21.2   0.2       0.57    9.7   0.1    2.5  2  AAA_7            P-loop containing dynein motor region
    0.00023   21.1   2.4       0.24   11.3   0.2    3.3  3  NACHT            NACHT domain
    0.00029   21.0   0.3       0.24   11.5   0.1    2.4  2  AAA_33           AAA domain
    0.00034   20.6   0.0       0.41   10.6   0.0    3.0  3  TsaE             Threonylcarbamoyl adenosine biosynthesis pro
     0.0007   19.4   0.4        1.1    8.9   0.0    2.4  2  AAA_24           AAA domain
     0.0017   18.1   0.1       0.99    9.2   0.0    2.5  2  AAA_29           P-loop containing region of AAA domain
     0.0021   17.8   0.1          4    7.1   0.0    3.1  3  Sigma54_activat  Sigma-54 interaction domain
     0.0022   18.1   0.0      0.013   15.6   0.0    2.1  2  Sigma54_activ_2  Sigma-54 interaction domain
     0.0023   17.2   0.1      0.012   14.9   0.0    2.1  2  Zeta_toxin       Zeta toxin
     0.0034   17.3   0.7       0.92    9.4   0.3    2.5  2  RsgA_GTPase      RsgA GTPase
     0.0034   16.3   0.2        4.5    6.1   0.0    3.1  3  AFG1_ATPase      AFG1-like ATPase
     0.0085   16.1   2.6       0.95    9.5   0.0    2.9  2  AAA_14           AAA domain
  ------ inclusion threshold ------
      0.012   15.5   0.1      0.074   12.9   0.0    2.1  2  APS_kinase       Adenylylsulphate kinase
      0.013   15.1   0.2        2.2    7.8   0.0    2.3  2  SRP54            SRP54-type protein, GTPase domain
      0.014   15.2   0.0        1.9    8.2   0.0    2.3  2  AAA_30           AAA domain
      0.014   15.3   1.0        7.4    6.5   0.4    2.9  3  Rad17            Rad17 P-loop domain
       0.02   14.6   0.0        7.8    6.2   0.0    2.5  2  RuvB_N           Holliday junction DNA helicase RuvB P-loop d
      0.025   14.8   0.7          3    8.1   0.1    2.3  2  AAA_28           AAA domain
      0.033   14.1   0.8        8.5    6.3   0.0    2.8  3  NTPase_1         NTPase
      0.043   14.2   0.3        3.9    7.8   0.0    3.1  2  AAA_19           AAA domain
      0.048   12.8   0.7        4.9    6.3   0.1    2.7  3  NB-ARC           NB-ARC domain
      0.061   12.9   0.6        8.7    5.9   0.2    2.3  2  AAA_25           AAA domain
       0.15   11.5   0.0         12    5.3   0.0    2.4  2  TniB             Bacterial TniB protein
       0.19   11.9   1.0         11    6.3   0.1    2.9  2  Roc              Ras of Complex, Roc, domain of DAPkinase
       0.25   11.1   0.2         16    5.1   0.0    3.0  3  Cytidylate_kin   Cytidylate kinase
       0.34   10.5   2.1         47    3.5   0.2    3.3  3  cobW             CobW/HypB/UreG, nucleotide-binding domain
       0.77    9.1   1.8        2.4    7.5   0.4    2.1  2  Mg_chelatase     Magnesium chelatase, subunit ChlI
        1.4    9.4   8.4        4.5    7.7   0.1    3.6  3  AAA_23           AAA domain


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.2   0.0   3.6e-08   1.7e-05       1     131 [.     265     376 ..     265     377 .. 0.87
   2 !   22.3   0.1   2.9e-07   0.00014       1      30 [.     522     551 ..     522     552 .] 0.94

  Alignments for each domain:
  == domain 1  score: 25.2 bits;  conditional E-value: 3.6e-08
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTS CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkk 99 
                 +ll+G  GtGK+++ + + ke     +e  g  ++   +g++++   ++f ++   +  + + +D++++l+k+               L+++l++    
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKE-----FERRGVVVR---FGNGSSFSMDMFHNLNLTK-GTLICLDDMENLGKNI------------GNLFSALQNIVFT 342
                 69*******************.....556666666...7888888899998876554.69**********6655............8899999998888 PP

                 SSTEEEEEEESS.GGGSTHHHHS.TTSSEEEETT CS
         AAA 100 eskvivigatnr.pdkldpallr.gRfdrkieie 131
                 ++k+ vi+++n+ ++++d+ ++  g f+r ++i+
  EFC38612.1 343 SGKCAVIAVSNKnVEEMDESIRQsGHFERDFYIP 376
                 899*******************99*******997 PP

  == domain 2  score: 22.3 bits;  conditional E-value: 2.9e-07
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEE CS
         AAA   1 vllyGppGtGKTllakavakelgvefleis 30 
                 +ll+Gp G+GKTll+k++a+  ++++++i+
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMGKMNYISIK 551
                 69*******************999999986 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   6.2e-07    0.0003      14      64 ..     249     302 ..     235     323 .. 0.79
   2 ?   -0.8   0.0       3.7   1.8e+03     135     160 ..     313     338 ..     303     349 .. 0.72
   3 !   18.2   0.1   5.4e-06    0.0026      25      45 ..     520     540 ..     512     549 .. 0.87

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 6.2e-07
      AAA_16  14 salervrsgrp...elvllsGesGvGKsslvrellralekdggiflrgkcdqle 64 
                 +++ r++++ +     +ll G +G+GKs+++r + +++e++g+++  g+  +++
  EFC38612.1 249 TLFFRASENYThlpKTILLWGLQGTGKSTILRYIGKEFERRGVVVRFGNGSSFS 302
                 4444566665566699*************************9888888887774 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 3.7
      AAA_16 135 rplvlvlDdlqwadeaslqllaaLlr 160
                 + ++++lDd++ +     +l++aL  
  EFC38612.1 313 KGTLICLDDMENLGKNIGNLFSALQN 338
                 45899*****9888777777777655 PP

  == domain 3  score: 18.2 bits;  conditional E-value: 5.4e-06
      AAA_16  25 elvllsGesGvGKsslvrell 45 
                 + +ll+G+sGvGK+ lv++l+
  EFC38612.1 520 CGILLHGPSGVGKTLLVKSLA 540
                 789***************998 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.2e-05     0.011       1      38 [.     265     312 ..     265     368 .. 0.73
   2 !   11.2   0.1   0.00082       0.4       1      24 [.     522     545 ..     522     552 .] 0.84

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.2e-05
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf..........gvnlrdvakengll 38 
                 Ill G +G+GK+t+ +++ k+ +           +  ++d++ + +l 
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKEFERrgvvvrfgngSSFSMDMFHNLNLT 312
                 899***************999644666667676766666666666665 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00082
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf 24 
                 Ill G++GvGKt l k L++++++
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMGKM 545
                 89****************999743 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.1    0.0014      0.67       7      31 ..     264     288 ..     260     307 .. 0.83
   2 ?    3.7   0.0      0.15        72      88     126 ..     312     349 ..     296     359 .. 0.71
   3 !   13.7   0.1   0.00012     0.058       8      27 ..     522     541 ..     520     548 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.0014
      AAA_22   7 ilvvtGesGtGKTtllrrlleqlde 31 
                  ++++G  GtGK+t lr + +++++
  EFC38612.1 264 TILLWGLQGTGKSTILRYIGKEFER 288
                 5899***************999963 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.15
      AAA_22  88 aravielliiDEaqhlrseealeeLrsllnl..srkgvqli 126
                 +++   l+ +D++++l  +++ + ++ l+n+   + ++++i
  EFC38612.1 312 TKG--TLICLDDMENL-GKNIGNLFSALQNIvfTSGKCAVI 349
                 444..49*********.888888889899987755555555 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 0.00012
      AAA_22   8 lvvtGesGtGKTtllrrlle 27 
                 ++++G+sG+GKT+l++ l++
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLAS 541
                 789*************9986 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   8.9e-06    0.0043      26      82 ..     229     291 ..     207     304 .. 0.67
   2 ?   -3.4   0.0         9   4.4e+03      36      54 ..     403     421 ..     391     423 .. 0.78
   3 ?    4.6   0.0     0.033        16      55      75 ..     521     541 ..     514     550 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 8.9e-06
      DUF815  26 klddLvgidkqkealve..nteqfleglp....annvLLwGarGtGKSslvkallneyaeegL 82 
                 + ++L g+++q e +++  +t  f + ++     + +LLwG +GtGKS++++ + +e++++g+
  EFC38612.1 229 SNNTLGGLNDQLEGILTilDTLFFRASENythlPKTILLWGLQGTGKSTILRYIGKEFERRGV 291
                 5555555555555544322344444333311113579********************999885 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 9
      DUF815  36 qkealventeqfleglpan 54 
                 +++++++n ++f++g+  +
  EFC38612.1 403 KRREFLSNLQRFVSGYVGR 421
                 4667889999**9998766 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.033
      DUF815  55 nvLLwGarGtGKSslvkalln 75 
                  +LL G  G+GK  lvk+l +
  EFC38612.1 521 GILLHGPSGVGKTLLVKSLAS 541
                 69***************9976 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.1    0.0034       1.6       2      47 ..     265     311 ..     264     346 .. 0.78
   2 !   13.0   0.1   0.00016     0.078       2      22 ..     522     542 ..     521     550 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0034
                 EEEE--SSSSHHHHHHHGGGGB.S--EEEEE--TT--HHHHH--B-- CS
       AAA_5   2 vlLvGppGtgKselaerlaaal.nreveyvqltrdtteedlkgrrei 47 
                 +lL G +GtgKs++ +++ + + +r v++  ++ +  + d++  +++
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKEFeRRGVVVRFGNGSSFSMDMFHNLNL 311
                 799***************99995555555555555555566666665 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 0.00016
                 EEEE--SSSSHHHHHHHGGGG CS
       AAA_5   2 vlLvGppGtgKselaerlaaa 22 
                 +lL Gp+G+gK+ l+++la++
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASM 542
                 89****************987 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   0.00043      0.21      12      66 ..     263     334 ..     259     387 .. 0.70
   2 !    9.1   0.1    0.0035       1.7      14      34 ..     522     542 ..     513     550 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00043
                 SEEEEEESTTSSHHHHHHHHTTSS--SEEEE............EETTCEGGG.............B-HHHCCHCEEEE-S CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............xxxxxxxxx.............xxxxxxxxxxxxxxx RF
    ABC_tran  12 ekvaivGenGaGKStLlkllagllkpteGei............lldgkdlke.............qeleslrkeigvlpq 66 
                 +++ + G  G+GKSt+l+ + ++ +   G +                                  +++e l k+ig l+ 
  EFC38612.1 263 KTILLWGLQGTGKSTILRYIGKEFE-RRGVVvrfgngssfsmdM-------FhnlnltkgtliclDDMENLGKNIGNLFS 334
                 578899**************99987.466654444444443331.......02233333444455666666666666665 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0035
                 EEEEESTTSSHHHHHHHHTTS CS
                 xxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  14 vaivGenGaGKStLlkllagl 34 
                 + + G++G GK+ L+k la +
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASM 542
                 6799*************9875 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0     0.005       2.4       1      26 [.     265     290 ..     265     357 .. 0.76
   2 !   11.9   0.1   0.00046      0.22       1      20 [.     522     541 ..     522     550 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.005
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkkl 26 
                   i+l+G +g+GKSt+ +++ k+++++ 
    EFC38612.1 265 ILLWGLQGTGKSTILRYIGKEFERRG 290
                   689**************999998654 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00046
  RNA_helicase   1 iwlyGpsgeGKStlakeLak 20 
                   i+l+Gpsg+GK++l+k+La+
    EFC38612.1 522 ILLHGPSGVGKTLLVKSLAS 541
                   689**************986 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.0    0.0022       1.1      40      92 ..     255     311 ..     245     367 .. 0.82
   2 !    9.1   0.1    0.0021         1      50      74 ..     522     546 ..     519     552 .] 0.80

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0022
   IstB_IS21  40 tlsfiekkenivllGpsGvGKshlaialgveavraglsvlfvr....vedLveelkr 92 
                 + ++++  + i+l G  G+GKs +   +g+e  r+g+ v+f        d++++l++
  EFC38612.1 255 SENYTHLPKTILLWGLQGTGKSTILRYIGKEFERRGVVVRFGNgssfSMDMFHNLNL 311
                 5667777889******************************96511113456666555 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0021
   IstB_IS21  50 ivllGpsGvGKshlaialgveavra 74 
                 i+l GpsGvGK+ l  +l+  +  +
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMGKMN 546
                 899*************999876555 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.0    0.0023       1.1      32      66 ..     261     295 ..     247     306 .. 0.82
   2 !    9.7   0.1    0.0012      0.57      36      62 ..     522     547 ..     519     551 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0023
       AAA_7  32 nkkpvllvGptGtGKtviikdllkkldkekylslt 66 
                   k +ll G +GtGK++i++ + k+++++ +++ +
  EFC38612.1 261 LPKTILLWGLQGTGKSTILRYIGKEFERRGVVVRF 295
                 56889**************9999999877776665 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0012
       AAA_7  36 vllvGptGtGKtviikdllkkldkeky 62 
                 +ll Gp+G+GKt+++k+l +  +  +y
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMGK-MNY 547
                 79**************9765433.555 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.2     0.078        38       2      24 ..     264     286 ..     263     293 .. 0.84
   2 ?    3.7   0.0      0.11        52      79     142 ..     311     366 ..     302     391 .. 0.84
   3 !   11.3   0.2    0.0005      0.24       3      22 ..     522     541 ..     521     548 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.078
                 CEEEEC-TTTCHHHHHHHHHHHH CS
       NACHT   2 lvilqGeaGsGKTtLlqklalaw 24 
                 +++l G +G GK+t l+ +  + 
  EFC38612.1 264 TILLWGLQGTGKSTILRYIGKEF 286
                 79999***********9886665 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.11
                 SCCCEEEEEE-STT-SS-TCH.........HHHHHCTTTTT--EEEEEEECCCHHHHCTTSSCE CS
       NACHT  79 lperlLlilDglDelvtdlgqkekqpvrtlLselirkkllpeasllltvrpralrdleeqleea 142
                 l + +L+ lD+++ l +  g+        l+s l +    ++ + +++v++++++++ e+++++
  EFC38612.1 311 LTKGTLICLDDMENLGKNIGN--------LFSALQNIVFTSGKCAVIAVSNKNVEEMDESIRQS 366
                 556689999999999999999........7777777777789999**************99998 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 0.0005
                 EEEEC-TTTCHHHHHHHHHH CS
       NACHT   3 vilqGeaGsGKTtLlqklal 22 
                 ++l+G++G+GKT L+++la+
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLAS 541
                 689**************997 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0     0.012         6       2      22 ..     265     285 ..     265     329 .. 0.85
   2 !   11.5   0.1    0.0005      0.24       2      22 ..     522     542 ..     522     550 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.012
      AAA_33   2 vllvGlpGsGKstlaerllkk 22 
                 +ll Gl+G+GKst ++ + k+
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKE 285
                 5789*********99876555 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.0005
      AAA_33   2 vllvGlpGsGKstlaerllkk 22 
                 +ll+G++G+GK+ l+++l+  
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASM 542
                 689**************9865 PP

>> TsaE  Threonylcarbamoyl adenosine biosynthesis protein TsaE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0         4   1.9e+03      53      77 ..     200     227 ..     196     250 .. 0.70
   2 ?    6.1   0.0     0.021        10      18      45 ..     261     288 ..     237     294 .. 0.81
   3 !   10.6   0.0   0.00085      0.41      22      44 ..     522     544 ..     490     551 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 4
                 TTSEEEEEE..SS...EEEEE-TT-SST CS
        TsaE  53 FtlveeYelekeg...lyHfDlYRlede 77 
                 F++ e ++++k +     H+D + + +e
  EFC38612.1 200 FSITEDFKNSKPTtrsTNHIDTFNFIEE 227
                 888889987766688899***9997433 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.021
                 HTEEEEEEESTTSSHHHHHHHHHHHTT- CS
        TsaE  18 lgdvilLeGdLGaGKTtlvrglakalgv 45 
                 l ++ilL G  G+GK+t+ r + k+++ 
  EFC38612.1 261 LPKTILLWGLQGTGKSTILRYIGKEFER 288
                 3567******************998865 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00085
                 EEEEESTTSSHHHHHHHHHHHTT CS
        TsaE  22 ilLeGdLGaGKTtlvrglakalg 44 
                 ilL+G+ G+GKT lv++la+  +
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMGK 544
                 99***************998655 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0    0.0023       1.1       3      35 ..     263     299 ..     261     347 .. 0.80
   2 !    8.3   0.1    0.0037       1.8       5      22 ..     522     539 ..     520     549 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0023
      AAA_24   3 lkiliyGpsgiGKTtlakel....gpkplfidtekGl 35 
                 + il++G +g+GK+t+++ +    + + +++ + +G+
  EFC38612.1 263 KTILLWGLQGTGKSTILRYIgkefERRGVVVRFGNGS 299
                 789*************999866666666666666655 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0037
      AAA_24   5 iliyGpsgiGKTtlakel 22 
                 il+ Gpsg+GKT l+k+l
  EFC38612.1 522 ILLHGPSGVGKTLLVKSL 539
                 799************998 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0     0.002      0.99      24      39 ..     264     279 ..     251     280 .. 0.81
   2 ?    6.1   0.0     0.018       8.9      25      39 ..     522     536 ..     512     542 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.002
      AAA_29  24 atlltGpsGsGKSTll 39 
                 ++ll G +G+GKST+l
  EFC38612.1 264 TILLWGLQGTGKSTIL 279
                 589***********97 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.018
      AAA_29  25 tlltGpsGsGKSTll 39 
                 +ll GpsG+GK+ l+
  EFC38612.1 522 ILLHGPSGVGKTLLV 536
                 79*********9887 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.0    0.0083         4      16      49 ..     256     289 ..     248     308 .. 0.81
   2 ?   -0.1   0.0       1.4   6.6e+02      93     160 ..     313     375 ..     307     380 .. 0.53
   3 ?    6.2   0.0     0.016       7.7      25      44 ..     522     541 ..     515     549 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0083
                      HHHCTSSS-EEEECSTTSSHHHHHHHHHHHSTTT CS
  Sigma54_activat  16 kkvaktdlsvlitGesGtGKellaraiheaskrk 49 
                      +++++ + ++l+ G +GtGK+++ r i ++ +r+
       EFC38612.1 256 ENYTHLPKTILLWGLQGTGKSTILRYIGKEFERR 289
                      566778899**************99998877765 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 1.4
                      TTSEEEEETGGGS-HHHHHHHHHHHHHSEEESBTSSSEEE--EEEEEEESS-HHHH....HHTTSS-HHHHH CS
  Sigma54_activat  93 dgGtlfLDeigelplelQekLlrvlqegevervGsskeikvdvriiaatnedleea....veegkfredLyy 160
                      +g  + LD++++l  ++  +L+ +lq+  ++  G+         +ia +n+++ee+     ++g+f +d+y 
       EFC38612.1 313 KGTLICLDDMENLGKNI-GNLFSALQNIVFTS-GKC-------AVIAVSNKNVEEMdesiRQSGHFERDFYI 375
                      55556667776666655.35666666655543.443.......44444444444331111245677777775 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.016
                      EEEECSTTSSHHHHHHHHHH CS
  Sigma54_activat  25 vlitGesGtGKellaraihe 44 
                      +l++G sG+GK+ll +++ +
       EFC38612.1 522 ILLHGPSGVGKTLLVKSLAS 541
                      89***********9998765 PP

>> Sigma54_activ_2  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   2.7e-05     0.013      23     117 ..     264     362 ..     251     373 .. 0.82
   2 ?   -0.7   0.0         3   1.5e+03      24      44 ..     522     542 ..     520     548 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.7e-05
                      -EEEEEETT--HHHHHHCC--TTS-EE--SSTTHHHH-HHHHHHH...TTTSEEEEEE-TT--HHHHHHHHHHHHHHT..TTT-EEEEEEEE-T CS
  Sigma54_activ_2  23 pvfltGekGsgkelvArlLhknsgpwleifvverlaklpldlleq...akggtLylkdiadlskaeqkeLlellakae..ksslrlVstsskdl 111
                       ++l G +G+gk+++ r++ k+ ++   ++++ ++++  +d++ +    kg ++ l d+++l+k+   +L  +l++      ++ ++++s k++
       EFC38612.1 264 TILLWGLQGTGKSTILRYIGKEFERRGVVVRFGNGSSFSMDMFHNlnlTKGTLICLDDMENLGKNI-GNLFSALQNIVftSGKCAVIAVSNKNV 356
                      5899**************************************99955347777789*******975.456666666322257999*******99 PP

                      TT..-- CS
  Sigma54_activ_2 112 eqllea 117
                      e++ e+
       EFC38612.1 357 EEMDES 362
                      986554 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 3
                      EEEEEETT--HHHHHHCC--T CS
  Sigma54_activ_2  24 vfltGekGsgkelvArlLhkn 44 
                      ++l G+ G gk+l  + L++ 
       EFC38612.1 522 ILLHGPSGVGKTLLVKSLASM 542
                      678899999999888888765 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0   2.5e-05     0.012      14      49 ..     260     295 ..     249     299 .. 0.88
   2 ?   -1.6   0.1       2.8   1.3e+03      19      47 ..     522     548 ..     521     551 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2.5e-05
  Zeta_toxin  14 erPklillgGqpGAGKselaellkdelerqgnvvrl 49 
                   Pk ill G +G GKs++++++ +e+er+g vvr+
  EFC38612.1 260 HLPKTILLWGLQGTGKSTILRYIGKEFERRGVVVRF 295
                 569************************999999987 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 2.8
  Zeta_toxin  19 illgGqpGAGKselaellkdelerqgnvv 47 
                 ill G +G GK+ l + l+     + n++
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMG--KMNYI 548
                 78999*******9998877654..55555 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0     0.027        13     100     122 ..     263     285 ..     253     299 .. 0.83
   2 !    9.4   0.3    0.0019      0.92     103     124 ..     523     544 ..     520     551 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.027
                  SEEEEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase 100 ktsvlvGqSGvGKStLinallpe 122
                  kt++l G  G GKSt++  +  e
   EFC38612.1 263 KTILLWGLQGTGKSTILRYIGKE 285
                  8999*************988766 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0019
                  EEECSTTSSHHHHHHHHCTT-- CS
  RsgA_GTPase 103 vlvGqSGvGKStLinallpele 124
                  +l G+SGvGK+ L+++l++  +
   EFC38612.1 523 LLHGPSGVGKTLLVKSLASMGK 544
                  689**************98655 PP

>> AFG1_ATPase  AFG1-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0       0.2        96      49      79 ..     248     279 ..     223     289 .. 0.80
   2 !    6.1   0.0    0.0092       4.5     127     220 ..     313     412 ..     293     434 .. 0.78
   3 ?    4.5   0.0     0.027        13      61      81 ..     518     538 ..     511     542 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.2
  AFG1_ATPase  49 gklfgrkr.ksvepvrglYlwGgvGrGKtylm 79 
                    lf+r   + ++ ++ + lwG  G GK+ ++
   EFC38612.1 248 DTLFFRASeNYTHLPKTILLWGLQGTGKSTIL 279
                  566766653566789**************987 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0092
  AFG1_ATPase 127 earvlCfDEfevsDiadamllsrLleaLfarg.vtlvaTSNiaPedLyk.....dglqrqrFLpaIdlleshlevlevdggvDYRlrklrqaevylap 218
                  + +++C+D++e        l s L +  f  g  +++a SN   e++ +     + ++r+ ++p  + l+s+ evl+v+ ++ + l +l++ + +l+ 
   EFC38612.1 313 KGTLICLDDMENLGKNIGNLFSALQNIVFTSGkCAVIAVSNKNVEEMDEsirqsGHFERDFYIPIPSSLKSKREVLSVHFNRYFPLLSLEKRREFLSN 410
                  45589999887655444557788888888876489*******99998652223368999999*******************99999999999888877 PP

  AFG1_ATPase 219 ld 220
                  l+
   EFC38612.1 411 LQ 412
                  65 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.027
  AFG1_ATPase  61 pvrglYlwGgvGrGKtylmdl 81 
                  p  g+ l+G+ G+GKt l+ +
   EFC38612.1 518 PCCGILLHGPSGVGKTLLVKS 538
                  667999***********9865 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0     0.002      0.95       3      95 ..     263     348 ..     262     368 .. 0.72
   2 ?    5.7   0.1      0.03        14       5      25 ..     522     542 ..     521     551 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.002
      AAA_14   3 kilvitGaRrvGKTtllkqlikellvkkesilyinldderdkkladpekllelileklkeekktylflDEiqev....pewekalkslvdegknldv 95 
                 k +++ G+  +GK+t+l+ + ke     ++ + + + + +  ++       +++ ++  + k t+++lD + ++     ++++al+++v ++ ++ v
  EFC38612.1 263 KTILLWGLQGTGKSTILRYIGKEFE---RRGVVVRFGNGSSFSM-------DMFHNLNLT-KGTLICLDDMENLgkniGNLFSALQNIVFTSGKCAV 348
                 678999***********99998877...8889999998766543.......455555333.678999999987755556677777776665545444 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.03
      AAA_14   5 lvitGaRrvGKTtllkqlike 25 
                 +++ G+  vGKT l+k l++ 
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASM 542
                 5799************99854 PP

>> APS_kinase  Adenylylsulphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   0.00015     0.074       3      53 ..     263     313 ..     261     387 .. 0.81
   2 ?   -0.1   0.0       1.5   7.5e+02       3      23 ..     520     540 ..     518     549 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 0.00015
                 EEEEEESSTTSSHHHHHHHHHHHHHHTT--EEEEEHHHHTTTTTTT--SSH CS
  APS_kinase   3 vvvwltGlsgsGKstianalekkLvekgisvylLdGdnvRhgLnkdLgfse 53 
                  +++l Gl g+GKsti + + k+ +++g+ v   +G +  +++ ++L  ++
  EFC38612.1 263 KTILLWGLQGTGKSTILRYIGKEFERRGVVVRFGNGSSFSMDMFHNLNLTK 313
                 699**********************************99999999998876 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 1.5
                 EEEEEESSTTSSHHHHHHHHH CS
  APS_kinase   3 vvvwltGlsgsGKstianale 23 
                 + ++l G sg GK+ + + l+
  EFC38612.1 520 CGILLHGPSGVGKTLLVKSLA 540
                 6699*********99887775 PP

>> SRP54  SRP54-type protein, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0    0.0046       2.2       1      29 [.     262     290 ..     262     306 .. 0.83
   2 ?    5.1   0.1     0.032        15       4      26 ..     522     544 ..     519     550 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0046
                 SEEEEEEESTTSSHHHHHHHHHHHHHHTT CS
       SRP54   1 pnvillvGlqGaGKTttlaKLaallkkeg 29 
                 p+ ill GlqG+GK t l  + + ++++g
  EFC38612.1 262 PKTILLWGLQGTGKSTILRYIGKEFERRG 290
                 5789************9988887777766 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.032
                 EEEEESTTSSHHHHHHHHHHHHH CS
       SRP54   4 illvGlqGaGKTttlaKLaallk 26 
                 ill G+ G+GKT  +  La + k
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMGK 544
                 89****************98765 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.0    0.0039       1.9      20      48 ..     264     292 ..     253     311 .. 0.84
   2 ?    4.4   0.1     0.054        26      22      41 ..     523     542 ..     521     548 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0039
      AAA_30  20 vavltGpAGtGKttalkalreaweaaggr 48 
                 + +l G  GtGK+t+l+ + + +e++g  
  EFC38612.1 264 TILLWGLQGTGKSTILRYIGKEFERRGVV 292
                 5678899************9999888854 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.054
      AAA_30  22 vltGpAGtGKttalkalrea 41 
                 +l+Gp G GKt ++k+l+ +
  EFC38612.1 523 LLHGPSGVGKTLLVKSLASM 542
                 689************99865 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0     0.021        10      46      71 ..     261     288 ..     237     326 .. 0.70
   2 ?   -2.3   0.0       7.5   3.7e+03     131     177 ..     312     356 ..     299     364 .. 0.60
   3 ?    6.5   0.4     0.015       7.4      48      71 ..     522     545 ..     519     551 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.021
       Rad17  46 r..iLLisGPsGCgkstvvkvLskelgi 71 
                     +L+ G  G gkst+++ + ke+  
  EFC38612.1 261 LpkTILLWGLQGTGKSTILRYIGKEFER 288
                 14467889****************9865 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 7.5
       Rad17 131 tdkklilvedlPnkfyrdsdalrevirkylrssealplilviteies 177
                 t+  li ++d+ n  +   + +  +   + +s+++   ++ +++ + 
  EFC38612.1 312 TKGTLICLDDMENLGKNIGNLFSALQNIVFTSGKC--AVIAVSNKNV 356
                 66778888888876555555555555555677777..4444554444 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.015
       Rad17  48 LLisGPsGCgkstvvkvLskelgi 71 
                 +L+ GPsG gk+  vk L+    +
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMGKM 545
                 5899**************976555 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.0     0.016       7.8      21     108 ..     250     336 ..     240     348 .. 0.73
   2 ?    5.6   0.1     0.025        12      36      55 ..     522     541 ..     518     549 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.016
      RuvB_N  21 ifieaakkreealdhvllyGpPGlGkttlakiiakelg...vklkitsgPvlekagdlaalltnleekdvlfideihrlsraveevlysam 108
                 +f +a+++ ++    +ll G  G Gk+t+ + i ke++   v ++   g     + d+   l nl+++ ++ +d++  l +++ + l+sa+
  EFC38612.1 250 LFFRASENYTHLPKTILLWGLQGTGKSTILRYIGKEFErrgVVVRFGNGSS--FSMDMFHNL-NLTKGTLICLDDMENLGKNIGN-LFSAL 336
                 567778888888889********************9862114455555544..455666555.6777888888888888777765.45555 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.025
      RuvB_N  36 vllyGpPGlGkttlakiiak 55 
                 +ll+Gp G+Gkt l k +a+
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLAS 541
                 89***********9988875 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.1     0.052        25       2      22 ..     265     285 ..     264     299 .. 0.76
   2 ?    8.1   0.1    0.0062         3       2      23 ..     522     543 ..     521     550 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.052
      AAA_28   2 ivitGgestGKTtlleaLaar 22 
                 i + G ++tGK+t+l+ + ++
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKE 285
                 788999*********887743 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0062
      AAA_28   2 ivitGgestGKTtlleaLaarg 23 
                 i + G+++ GKT l++ La++g
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASMG 543
                 7899***************884 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.0     0.018       8.5       2      30 ..     265     293 ..     264     296 .. 0.90
   2 ?   -2.5   0.0       8.5   4.1e+03     101     146 ..     319     365 ..     305     370 .. 0.63
   3 ?    5.5   0.1      0.03        15       2      22 ..     522     542 ..     521     551 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.018
                 EEEE--TTSSHHHHHHHHHHHH...GGGE CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlellkssgvkv 30 
                 +++ G +G+GK+T+++ + ++ +++gv v
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKEFERRGVVV 293
                 678899*****************999987 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 8.5
                 E---STTGGG-HHHHHHHHHHHT.TTSEEEEE--SS--SHHHHHHHT CS
    NTPase_1 101 iDEiGkmElkskkfkeaveevLk.sekpvlavihrrkdlalveeire 146
                 +D   ++  ++ ++ +a+++++  s+k  ++ + +++ +++ e+ir+
  EFC38612.1 319 LDDMENLGKNIGNLFSALQNIVFtSGKCAVIAVSNKNVEEMDESIRQ 365
                 55555555555556666666655577777777777766666666666 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.03
                 EEEE--TTSSHHHHHHHHHHH CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlel 22 
                 +++ Gp+GvGKt lvk ++++
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLASM 542
                 6899***********998876 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0     0.008       3.9       8      40 ..     260     292 ..     253     369 .. 0.65
   2 ?    1.9   0.1      0.55   2.6e+02      13      30 ..     522     539 ..     519     548 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.008
      AAA_19   8 lkekvllvtaGpGtGKTrvlkhivallvelggv 40 
                 +  k++l+ +  GtGK+++l+ i ++++++g v
  EFC38612.1 260 HLPKTILLWGLQGTGKSTILRYIGKEFERRGVV 292
                 5678999999*************9999998866 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.55
      AAA_19  13 llvtaGpGtGKTrvlkhi 30 
                 +l+ ++ G GKT ++k  
  EFC38612.1 522 ILLHGPSGVGKTLLVKSL 539
                 6789999*****998865 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.058        28      23      45 ..     265     287 ..     258     296 .. 0.87
   2 ?    1.2   0.1      0.36   1.7e+02      65     112 ..     275     322 ..     271     355 .. 0.70
   3 ?    6.3   0.1      0.01       4.9      23      42 ..     522     541 ..     518     552 .] 0.84

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.058
                 EEEEESTTSSHHHHHHHHCCSHC CS
      NB-ARC  23 valvGmgGvGKttlakqilnksd 45 
                 + l G  G GK+t+++ i ++++
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKEFE 287
                 7799************9998865 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.36
                 HHHHHHXXHHHHHCCCTTSSSS-STTSHHHHHHHHCCCTTEEEEEEEE CS
      NB-ARC  65 seeiletilkeLslseddleekeeveslkrklvrlLltkrfllvlDDV 112
                 +++il+ i ke++++       + +    ++ ++l ltk +l+ lDD 
  EFC38612.1 275 KSTILRYIGKEFERRGVVVRFGNGSSFSMDMFHNLNLTKGTLICLDDM 322
                 456777777777666555544444444677777887888888888886 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.01
                 EEEEESTTSSHHHHHHHHCC CS
      NB-ARC  23 valvGmgGvGKttlakqiln 42 
                 + l+G  GvGKt l+k+  +
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLAS 541
                 679***********998765 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0     0.033        16      34      50 ..     263     279 ..     256     283 .. 0.87
   2 ?    5.9   0.2     0.018       8.7      36      54 ..     522     540 ..     519     542 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.033
      AAA_25  34 elallaGapgtGKttla 50 
                 +++ll+G +gtGK+t++
  EFC38612.1 263 KTILLWGLQGTGKSTIL 279
                 679************86 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.018
      AAA_25  36 allaGapgtGKttlaldla 54 
                 +ll G++g+GKt l+ +la
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLA 540
                 689***********99988 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.086        42      33      54 ..     260     281 ..     237     289 .. 0.68
   2 ?    5.3   0.0     0.024        12      37      58 ..     521     542 ..     493     547 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.086
        TniB  33 krmpnlllvGdsnnGKtmivek 54 
                 + ++ +ll+G + +GK++i++ 
  EFC38612.1 260 HLPKTILLWGLQGTGKSTILRY 281
                 345789*************975 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.024
        TniB  37 nlllvGdsnnGKtmivekFarl 58 
                  +ll+G+s +GKt +v++ a++
  EFC38612.1 521 GILLHGPSGVGKTLLVKSLASM 542
                 479*************998765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1      0.19        94       2      26 ..     265     288 ..     264     365 .. 0.85
   2 ?    6.3   0.1     0.023        11       2      20 ..     522     540 ..     521     547 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.19
                 EEEESSTTSSHHHHHHCHCT-CCC- CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfse 26 
                 ++l G +g+GK+++l r++ ++f++
  EFC38612.1 265 ILLWGLQGTGKSTIL-RYIGKEFER 288
                 6788999****9987.677777765 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.023
                 EEEESSTTSSHHHHHHCHC CS
         Roc   2 vvlvGdsgvGKtsllkrfv 20 
                 ++l G sgvGKt l+k++ 
  EFC38612.1 522 ILLHGPSGVGKTLLVKSLA 540
                 6788***********9986 PP

>> Cytidylate_kin  Cytidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.71   3.4e+02      41      85 ..     111     155 ..      72     161 .. 0.78
   2 ?    0.7   0.0      0.74   3.6e+02       5      23 ..     269     287 ..     265     291 .. 0.84
   3 ?    5.1   0.0     0.033        16       2      27 ..     523     548 ..     522     550 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.71
                     HHTT--TT-HHHHHHHHHT--EEEEEEEEEETTEE-TTG.GGSHHH CS
  Cytidylate_kin  41 lrrkvdlldeaalvelakevelsfeaekvllngedveee.lrsdev 85 
                     ++ +++++d +++++++ +++l fe+++++ ++e+  ++ ++s+ +
      EFC38612.1 111 INVQIKFIDSDDVLKFIDRIKL-FESKSIFKKKENFFSHlIKSKLI 155
                     344999***************9.88888888888764442666655 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.74
                     -STTSSHHHHHHHHHHHHT CS
  Cytidylate_kin   5 GPagsGKssvaralaeklg 23 
                     G  g+GKs++ r ++++++
      EFC38612.1 269 GLQGTGKSTILRYIGKEFE 287
                     6679*********999875 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.033
                     EEE-STTSSHHHHHHHHHHHHT-EEE CS
  Cytidylate_kin   2 aiDGPagsGKssvaralaeklglkyl 27 
                      + GP+g GK  + + la+  +++y+
      EFC38612.1 523 LLHGPSGVGKTLLVKSLASMGKMNYI 548
                     578****************9999887 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.37   1.8e+02      81      99 ..     160     178 ..     122     205 .. 0.76
   2 ?    2.8   0.1      0.16        79       3      27 ..     265     289 ..     263     319 .. 0.81
   3 ?    3.5   0.2     0.097        47       4      22 ..     523     541 ..     521     550 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.37
                 TT-SEEEEEECTTTTHHHH CS
        cobW  81 erldviliEttGlaePapv 99 
                  + ++iliE+ G+  P  +
  EFC38612.1 160 MNGERILIECMGVQYPILL 178
                 5789**********99988 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.16
                 EEEEESTTCCHHHHHHHHHCT--SS CS
        cobW   3 tvltGflGsGKTtLlnhllenragl 27 
                 ++l G  G+GK+t+l+ + ++ + +
  EFC38612.1 265 ILLWGLQGTGKSTILRYIGKEFERR 289
                 6788999********9987655444 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.097
                 EEEESTTCCHHHHHHHHHC CS
        cobW   4 vltGflGsGKTtLlnhlle 22 
                 +l G+ G GKT L+++l +
  EFC38612.1 523 LLHGPSGVGKTLLVKSLAS 541
                 689***********99875 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.88   4.3e+02      24      40 ..     264     280 ..     262     284 .. 0.85
   2 ?    7.5   0.4     0.005       2.4      25      44 ..     522     541 ..     520     546 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.88
  Mg_chelatase  24 nlllvGppGsGKtmlak 40 
                    +ll G  G+GK+ + +
    EFC38612.1 264 TILLWGLQGTGKSTILR 280
                   589**********9876 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.005
  Mg_chelatase  25 lllvGppGsGKtmlakrlps 44 
                   +ll Gp+G GKt+l k l+s
    EFC38612.1 522 ILLHGPSGVGKTLLVKSLAS 541
                   79**************9986 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   2.7       2.3   1.1e+03      86     124 ..     174     228 ..      78     259 .. 0.46
   2 ?    7.7   0.1    0.0092       4.5      20      39 ..     263     282 ..     250     283 .. 0.89
   3 ?    2.7   0.0      0.32   1.5e+02      23      37 ..     523     537 ..     513     541 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 2.3
      AAA_23  86 y................trsiererelskkkgkttkkaklelleideleqfisel 124
                 y                ++++++e++ s ++  + +k +++++++ ++ +fi+el
  EFC38612.1 174 YpillnieetvgneksvYYRVTNEFNFSITEDFKNSKPTTRSTNHIDTFNFIEEL 228
                 1333333333333333444444455544444444444444444444444444443 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0092
      AAA_23  20 gltlItGpNGaGKTTildAi 39 
                 +  l++G  G+GK+Til+ i
  EFC38612.1 263 KTILLWGLQGTGKSTILRYI 282
                 56899***********9865 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.32
      AAA_23  23 lItGpNGaGKTTild 37 
                 l++Gp G GKT ++ 
  EFC38612.1 523 LLHGPSGVGKTLLVK 537
                 89*********8876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (552 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        37  (0.0020637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              37  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.44
# Mc/sec: 3741.01
//
Query:       EFC38613.1  [L=381]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00072   18.8   0.0     0.0025   17.0   0.0    1.9  3  LCAT           Lecithin:cholesterol acyltransferase
    0.00073   19.1   0.0      0.063   12.8   0.0    2.3  2  DUF900         Alpha/beta hydrolase of unknown function (DUF9
  ------ inclusion threshold ------
      0.097   11.9   0.0       0.39   10.0   0.0    1.9  2  Hydrolase_4    Serine aminopeptidase, S33
       0.15   11.7   0.0       0.32   10.6   0.0    1.5  1  Abhydrolase_8  Alpha/beta hydrolase


Domain annotation for each model (and alignments):
>> LCAT  Lecithin:cholesterol acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0      0.67     3e+03     114     132 ..      92     110 ..      82     112 .. 0.78
   2 !   17.0   0.0   5.6e-07    0.0025     117     174 ..     181     235 ..     165     289 .. 0.81
   3 ?   -3.5   0.0         1   4.5e+03     150     170 ..     355     375 ..     340     378 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.67
        LCAT 114 ealklsgkkvvliaHSmGn 132
                 ++ ++++kk++l+ H  G 
  EFC38613.1  92 QVEQSEEKKICLFVHGCGE 110
                 45568999*******9886 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 5.6e-07
        LCAT 117 klsgkkvvliaHSmGnllvlyflkwveaeaWvdqhikafislgapllGsvkavkalls 174
                 ++  ++v+++aHSmGnl++   lk++  ++  d+   ++ +l +p+ G  kav +l+ 
  EFC38613.1 181 DNTVRNVIVFAHSMGNLIIAGALKNNLCKI--DKETVSWYNLMGPMKGT-KAVSVLKE 235
                 456679*******************88888..99999999*****9995.77777765 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 1
        LCAT 150 qhikafislgapllGsvkavk 170
                 +h +a    g ++ Gsvk+  
  EFC38613.1 355 NHADATCRFGDAWFGSVKPCS 375
                 677888889999999999876 PP

>> DUF900  Alpha/beta hydrolase of unknown function (DUF900)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.9   0.0    0.0071        32       8      27 ..      88     107 ..      84     111 .. 0.85
   2 !   12.8   0.0   1.4e-05     0.063      88     114 ..     179     205 ..     167     236 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.0071
      DUF900   8 alakelkksaakeilvfvhG 27 
                 + ++++++s++k+i +fvhG
  EFC38613.1  88 KCQQQVEQSEEKKICLFVHG 107
                 66789999***********9 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 1.4e-05
      DUF900  88 atkksakkihllaHSmGtwlvlealrq 114
                 at++ ++++ ++aHSmG+ +++ al++
  EFC38613.1 179 ATDNTVRNVIVFAHSMGNLIIAGALKN 205
                 4567799***************99985 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.19   8.5e+02       2      15 ..      97     110 ..      96     114 .. 0.85
   2 ?   10.0   0.0   8.6e-05      0.39      71     102 ..     180     211 ..     165     272 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.19
  Hydrolase_4   2 epkavvvlvHGlae 15 
                  e+k+++++vHG +e
   EFC38613.1  97 EEKKICLFVHGCGE 110
                  6899*******998 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 8.6e-05
  Hydrolase_4  71 eehpelplfllGhSmGGliallyllrypdkva 102
                  +++  +++++++hSmG li + +l+++  k++
   EFC38613.1 180 TDNTVRNVIVFAHSMGNLIIAGALKNNLCKID 211
                  3444459**************99977766555 PP

>> Abhydrolase_8  Alpha/beta hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   7.2e-05      0.32      96     130 ..     172     206 ..     167     223 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 7.2e-05
  Abhydrolase_8  96 allrdlratsvpgqhlallgHSYGSlvaslAldda 130
                    ++ ++l+at ++ +++ +++HS G l+ + Al++ 
     EFC38613.1 172 KYANQLNATDNTVRNVIVFAHSMGNLIIAGALKNN 206
                    7999****************************984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       667  (0.0372023); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.24s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 2537.58
//
Query:       EFC38614.1  [L=335]
Description: hypothetical protein NAEGRDRAFT_52938 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.3e-13   49.3   1.0    9.9e-13   48.2   0.1    2.0  2  FOP_dimer  FOP N terminal dimerisation domain
    1.2e-06   27.4   0.1      2e-06   26.7   0.1    1.4  1  LisH_2     LisH
  ------ inclusion threshold ------
      0.043   14.6   1.4       0.95   10.3   0.2    2.5  2  DUF3349    Protein of unknown function (DUF3349)
       0.11   12.8   1.4        2.1    8.7   0.3    2.4  2  EnY2       Transcription factor e(y)2
        0.6   10.5  10.2        2.2    8.6   3.1    3.1  2  Muted      Organelle biogenesis, Muted-like protein


Domain annotation for each model (and alignments):
>> FOP_dimer  FOP N terminal dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.2   0.1   2.8e-16   9.9e-13      19      81 .]      62     129 ..      45     129 .. 0.85
   2 ?   -2.1   0.1       1.3   4.7e+03      50      76 ..     135     162 ..     132     163 .. 0.67

  Alignments for each domain:
  == domain 1  score: 48.2 bits;  conditional E-value: 2.8e-16
   FOP_dimer  19 rlvaeLirefLeffeldytlsvfspEanlseelddRealskeLnise.....sdsaknkPLLlevvkr 81 
                  l++eL  e+Le++++dyt svf  E n+++e  d+ +l++eLni +     ++ + ++PLL+ +++r
  EFC38614.1  62 FLINELFIEYLEYNNMDYTKSVFLKECNQPQERLDKRFLAHELNIRKtydemDEDGDSVPLLYSIIHR 129
                 589******************************************753333367799********975 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1.3
   FOP_dimer  50 elddRealskeLnisesdsa.knkPLLl 76 
                 + + R+ +++e +++ + s   +kP+L+
  EFC38614.1 135 VRERRKDMANERKLQSDTSDiYQKPILH 162
                 4566788888888777665425788887 PP

>> LisH_2  LisH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.1   5.6e-10     2e-06       1      27 [.      64      90 ..      64      91 .. 0.94

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 5.6e-10
      LisH_2  1 lnsLvaeYLqsqgYnYTLSVFlPEsGl 27
                +n L  eYL++++++YT SVFl E++ 
  EFC38614.1 64 INELFIEYLEYNNMDYTKSVFLKECNQ 90
                6999*********************95 PP

>> DUF3349  Protein of unknown function (DUF3349)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1     0.071   2.5e+02      30      83 ..      10      64 ..       4      70 .. 0.76
   2 ?   10.3   0.2   0.00027      0.95      11      84 ..     107     177 ..     101     183 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.071
                HCTT--HHHH.HHHHHHHHHH--.SSS.BSHHHCHHHHHHHCTS---HHHHHHHH CS
     DUF3349 30 LrrrLsdeev.kevaeelvaeaaeadeavdeedieelitkvteeepseedvarVa 83
                L+ +L ++ v +++ ++l ae  ++ e+ d+++  e+  k  +++p+++d++ + 
  EFC38614.1 10 LKDNLEKRGVlNKIRANLRAEIFKTFEEQDHDETTEYWLKKQSSKPKPSDIQFLI 64
                6666666655356777777777777788899999999999999*******98665 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00027
                 HHH-TT-B-HHHHHHHHHHHCTT--HHHHHHHHHHHHHH--.SSS.BSHHHCHHHHHHHCTS---HHHHHHHHH CS
     DUF3349  11 ragYPegvPeqdyvpLlalLrrrLsdeevkevaeelvaeaaeadeavdeedieelitkvteeepseedvarVaa 84 
                 r+ Y e   + d vpLl+ + +rL +e+v+e  +++++e++    + d++di +     +e +  +++++r+++
  EFC38614.1 107 RKTYDEMDEDGDSVPLLYSIIHRLRNENVRERRKDMANERK---LQSDTSDIYQKPILHMEPNKAQDEIDRIQK 177
                 66777777788***************************993...344555665444344444445567888876 PP

>> EnY2  Transcription factor e(y)2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.3    0.0006       2.1      15      49 ..       4      38 ..       2      57 .. 0.84
   2 ?    2.6   0.0      0.05   1.8e+02       6      44 ..     111     149 ..     107     200 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0006
                HHHHHHHHHHHHHTTHHHHHHHHHHHHHHH..HTS CS
        EnY2 15 erlkelLrerLeesGWrdevkelckeiirekglee 49
                e++k+ L+ +Le+ G   ++++  + +i ++ +e+
  EFC38614.1  4 EEIKDILKDNLEKRGVLNKIRANLRAEIFKTFEEQ 38
                89**************************9865554 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.05
                 HHHHHTTHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHH CS
        EnY2   6 qkLvesGererlkelLrerLeesGWrdevkelckeiire 44 
                 +++ e G+   l   + +rL +++ r++ k++++e   +
  EFC38614.1 111 DEMDEDGDSVPLLYSIIHRLRNENVRERRKDMANERKLQ 149
                 567888999999999999999999999999999987654 PP

>> Muted  Organelle biogenesis, Muted-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   3.1    0.0006       2.2     107     145 ..      78     116 ..       4     116 .. 0.92
   2 ?    5.2   0.2    0.0069        25       9     119 ..     184     293 ..     176     296 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0006
       Muted 107 kaeweeflkelqekkeevDeefeekveelkekYselekk 145
                    ++ flke ++ +e++D+ f   + ++++ Y+e++++
  EFC38614.1  78 DYTKSVFLKECNQPQERLDKRFLAHELNIRKTYDEMDED 116
                 556789******************************975 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0069
       Muted   9 sRLlDhRpviqgEikyfvkeFEekRgdrevelLenikklvnelkeqllpkcles...mkenLselnkkleaalekverllqkeleeekrkseqlqekee 104
                 +RL+  +p ++  +k   + +++k+ d +++++++ ++  +  + +  +  l +    +++Ls l+kk    ++  + l+++ +e    ks+++ + ++
  EFC38614.1 184 QRLFPSQPNVNRHVKQTFQTIDSKKIDLNSSSISSSSSSPRRSDGDEVDYALSKliqQNSKLSRLQKK-TSPTHPGTGLERMIQEP---KSSRMFNINR 278
                 68888888888888888888888888888888888887777666665555555444458899999999.78888888888884443...4688888888 PP

       Muted 105 erkaeweeflkelqe 119
                 er++++++f +++++
  EFC38614.1 279 ERHNHEDSFCDDQST 293
                 99999999*999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1132  (0.0631379); expected 358.6 (0.02)
Passed bias filter:                      508  (0.028334); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.51u 0.26s 00:00:00.77 Elapsed: 00:00:00.42
# Mc/sec: 2389.96
//
Query:       EFC38615.1  [L=494]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.3e-13   47.7  13.4    5.5e-09   35.4   4.5    2.7  2  Hexapep    Bacterial transferase hexapeptide (six repeats)
    0.00013   21.6   5.9    0.00013   21.6   5.9    3.7  4  Hexapep_2  Hexapeptide repeat of succinyl-transferase
     0.0044   17.4   0.0      0.014   15.8   0.0    1.8  2  SATase_N   Serine acetyltransferase, N-terminal


Domain annotation for each model (and alignments):
>> Hexapep  Bacterial transferase hexapeptide (six repeats)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   1.5   6.1e-07    0.0036       2      36 .]     199     235 ..     193     235 .. 0.93
   2 !   35.4   4.5   9.2e-13   5.5e-09       1      34 [.     244     277 ..     244     279 .. 0.94

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 6.1e-07
                 EEEETTEEE-T..TEEEETTEEE-TTEEEETTEEEES CS
     Hexapep   2 tvIGsnvlIgp..faviggnVkIGdnvkIgagvvigg 36 
                 ++IG++ +I++  ++vig+ +++G+++++  gv++gg
  EFC38615.1 199 ARIGKGFFIDHgcGVVIGETAILGNYCTLYQGVTLGG 235
                 78999999999***********************997 PP

  == domain 2  score: 35.4 bits;  conditional E-value: 9.2e-13
                 TEEEETTEEE-TTEEEETTEEE-TTEEEETTEEE CS
     Hexapep   1 stvIGsnvlIgpfaviggnVkIGdnvkIgagvvi 34 
                 ++++G+nvl+g++++++gn++IG+nvkIgag+v+
  EFC38615.1 244 HPTLGDNVLVGAGSKVLGNIIIGSNVKIGAGSVV 277
                 5789*****************************9 PP

>> Hexapep_2  Hexapeptide repeat of succinyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.21   1.2e+03      13      33 ..     188     208 ..     184     209 .. 0.79
   2 !    4.1   1.5    0.0066        40      13      32 ..     210     233 ..     198     234 .. 0.54
   3 !   21.6   5.9   2.2e-08   0.00013       4      32 ..     247     277 ..     246     279 .. 0.93
   4 ?   -1.6   0.1      0.39   2.3e+03       9      26 ..     309     330 ..     306     331 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.21
                 T-EESEEE-TT-EE-TT-EE- CS
   Hexapep_2  13 nagiGvslGdncvvgaGvvit 33 
                 ++ +G+++  ++ +g G +i+
  EFC38615.1 188 RSWTGIEIHPGARIGKGFFID 208
                 566799999999999888875 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.0066
                 T-E..ES..EEE-TT-EE-TT-EE CS
   Hexapep_2  13 nag..iG..vslGdncvvgaGvvi 32 
                  +g  iG   +lG+ c+++ Gv++
  EFC38615.1 210 GCGvvIGetAILGNYCTLYQGVTL 233
                 555333555666666666666654 PP

  == domain 3  score: 21.6 bits;  conditional E-value: 2.2e-08
                 E-TT-EE-TT-EE.S.EEE-TT-EE-TT-EE CS
   Hexapep_2   4 IGdnCliGanagi.G.vslGdncvvgaGvvi 32 
                  Gdn+l+Ga + + G +++G n+++gaG+v+
  EFC38615.1 247 LGDNVLVGAGSKVlGnIIIGSNVKIGAGSVV 277
                 59**********8899**************9 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 0.39
                 EE-TT-E.E...SEEE-TT-EE CS
   Hexapep_2   9 liGanag.i...GvslGdncvv 26 
                 + Ga+++ i   G++l dn +v
  EFC38615.1 309 NTGASSEaIadnGTKLIDNNIV 330
                 5599999778999999888665 PP

>> SATase_N  Serine acetyltransferase, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   2.3e-06     0.014      43      96 ..      87     140 ..      77     146 .. 0.91
   2 ?   -3.3   0.0       2.1   1.2e+04      61      87 ..     449     475 ..     441     479 .. 0.65

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.3e-06
                 HHH-BSSS-HHHHHHHHHHHHHH-THHHHHHHHHHHHHHHH-TT---THHHHHH CS
    SATase_N  43 nklasstlsaeqlrelfeealeadpeiveaaraDlkAvlerDpAcksyleplly 96 
                 +kl++++ + ++++e  e+++  ++ i +++++D+  +++ DpA ++yle +ly
  EFC38615.1  87 SKLSTTKQKPHTIEEHTESVCVCSEPIWSQLKSDVSVIIDNDPAFDNYLELILY 140
                 58999999999***********9999*************************998 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.1
                 HHHHH-THHHHHHHHHHHHHHHH-TT- CS
    SATase_N  61 ealeadpeiveaaraDlkAvlerDpAc 87 
                 +a +++++ +e+  + ++A ++ D  c
  EFC38615.1 449 KATTTQQTKQETYTEEITAGVDNDEEC 475
                 455556666667777777777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (494 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1351  (0.0753528); expected 358.6 (0.02)
Passed bias filter:                      620  (0.0345808); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2912.76
//
Query:       EFC38616.1  [L=268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.6e-15   55.4   7.4    0.00043   19.6   0.0    4.0  4  EF-hand_1   EF hand
    3.8e-15   54.5   4.2    0.00011   21.9   0.3    3.8  3  EF-hand_6   EF-hand domain
      3e-11   43.6   6.7    8.9e-09   35.7   1.4    2.6  2  EF-hand_7   EF-hand domain pair
    2.3e-09   36.3   4.9      0.031   13.8   0.4    3.7  3  EF-hand_5   EF hand
    5.6e-06   26.2   4.2       0.23   11.4   0.1    3.5  4  EF-hand_4   Cytoskeletal-regulatory complex EF hand
    0.00019   21.2  12.6       0.25   11.2   0.4    3.8  4  EF-hand_8   EF-hand domain pair
  ------ inclusion threshold ------
      0.091   13.0   0.1         11    6.3   0.0    2.9  3  Dockerin_1  Dockerin type I domain
       0.58    8.5   1.8       0.46    8.9   0.1    1.6  2  TMEM214     TMEM214, C-terminal, caspase 4 activator


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.4   3.2e+03      17      25 ..      94     102 ..      93     104 .. 0.78
   2 !   19.6   0.0   1.9e-07   0.00043       2      28 ..     135     161 ..     134     162 .. 0.89
   3 !   18.0   0.7   6.4e-07    0.0014       2      28 ..     171     197 ..     170     198 .. 0.93
   4 !   19.6   0.1     2e-07   0.00044       4      26 ..     224     246 ..     221     248 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.4
                 EEHHHHHHH CS
   EF-hand_1  17 IdfeEfkel 25 
                 I +eEf+++
  EFC38616.1  94 ILLEEFRNA 102
                 6689**986 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 1.9e-07
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 + +i + fD Dg+G Idf E+ + l++
  EFC38616.1 135 FHRIYEAFDLDGNGAIDFVELATGLST 161
                 678999***************999876 PP

  == domain 3  score: 18.0 bits;  conditional E-value: 6.4e-07
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 l+ +F ++D++gdG +  eE++++++k
  EFC38616.1 171 LRFVFGLIDVNGDGSVQQEEMIDFFRK 197
                 7889*********************98 PP

  == domain 4  score: 19.6 bits;  conditional E-value: 2e-07
                 HHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1   4 eiFrefDkDgdGkIdfeEfkell 26 
                 + F   D D++G+I+f+Ef++++
  EFC38616.1 224 RTFTSTDLDQNGTIEFDEFVQAV 246
                 678889**************987 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   1.2e-06    0.0027       2      28 ..     135     161 ..     134     165 .. 0.89
   2 !   21.9   0.3   4.7e-08   0.00011       2      28 ..     171     197 ..     171     207 .. 0.89
   3 !   14.2   0.1   1.4e-05     0.032       4      26 ..     224     246 ..     221     255 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.2e-06
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalrk 28 
                 +++++++fD dg+G id+ El   l++
  EFC38616.1 135 FHRIYEAFDLDGNGAIDFVELATGLST 161
                 78999****************999985 PP

  == domain 2  score: 21.9 bits;  conditional E-value: 4.7e-08
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalrk 28 
                 lr +F l+D++gdG++ +eE+++++rk
  EFC38616.1 171 LRFVFGLIDVNGDGSVQQEEMIDFFRK 197
                 6889**********************6 PP

  == domain 3  score: 14.2 bits;  conditional E-value: 1.4e-05
   EF-hand_6   4 eaFklfDkdgdGkidaeElrkal 26 
                 + F   D d +G+i ++E+++a 
  EFC38616.1 224 RTFTSTDLDQNGTIEFDEFVQAV 246
                 568999**************996 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.3   0.00032      0.72      14      67 ..     104     156 ..      95     160 .. 0.73
   2 !   35.7   1.4     4e-12   8.9e-09       4      70 ..     171     246 ..     168     247 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00032
   EF-hand_7  14 dgdgyldkeellrllrkifqga.gegsklsdeelellfkefDtdkdGvisfdEFl 67 
                 +  g l+k+ + +++++  +++ + +++++     ++ + fD+d++G i+f E+ 
  EFC38616.1 104 NEEGLLEKDNFFDVIKNTLSQKfDIQNSMPA--FHRIYEAFDLDGNGAIDFVELA 156
                 5678888888555666644333355555544..88999************99976 PP

  == domain 2  score: 35.7 bits;  conditional E-value: 4e-12
   EF-hand_7   4 lkeaFkelDtdgdgyldkeellrllrkifqga..gegsklsdee.......lellfkefDtdkdGvisfdEFlkly 70 
                 l+ +F ++D++gdg++ +ee+ +++rk+f g     g kl+++        l + f   D+d++G+i fdEF++++
  EFC38616.1 171 LRFVFGLIDVNGDGSVQQEEMIDFFRKFFVGQakMNGYKLTSQRwktledyLSRTFTSTDLDQNGTIEFDEFVQAV 246
                 6788****************888******999996666666633444222266666666**************985 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.1   3.2e-05     0.072       6      23 ..     140     157 ..     140     160 .. 0.88
   2 !   13.8   0.4   1.4e-05     0.031       4      21 ..     174     191 ..     171     198 .. 0.88
   3 !    9.9   0.0   0.00024      0.54       9      22 ..     230     243 ..     223     246 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.2e-05
                 HHH-SS-SSCE-HHHHHH CS
   EF-hand_5   6 qaiDlNgDGkIskeELkt 23 
                 +a+Dl+g G I++ EL t
  EFC38616.1 140 EAFDLDGNGAIDFVELAT 157
                 59***********99977 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 1.4e-05
                 HHHHH-SS-SSCE-HHHH CS
   EF-hand_5   4 tFqaiDlNgDGkIskeEL 21 
                 +F  iD+NgDG +  eE 
  EFC38616.1 174 VFGLIDVNGDGSVQQEEM 191
                 6899************97 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00024
                 -SS-SSCE-HHHHH CS
   EF-hand_5   9 DlNgDGkIskeELk 22 
                 Dl++ G+I ++E+ 
  EFC38616.1 230 DLDQNGTIEFDEFV 243
                 *************5 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.2   7.1e+03      73      84 ..      34      45 ..      18      60 .. 0.59
   2 !   11.4   0.1    0.0001      0.23       3      67 ..      86     157 ..      84     164 .. 0.79
   3 ?    3.4   0.1     0.031        70      42      69 ..     168     195 ..     160     206 .. 0.85
   4 !   11.1   0.1   0.00013       0.3      41      68 ..     218     245 ..     201     247 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.2
   EF-hand_4 73 fdlvngeikdvP 84
                 dl+n + ++ P
  EFC38616.1 34 ADLMNSKRRAKP 45
                344444444333 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.0001
   EF-hand_4   3 kleeleikkyweifsglkpednkltgdkvapvlknsklee...d....klekiwdladidedgkldfeefci 67 
                 k+ e e+k   e f+  ++e+  l +d+   v+kn+  ++   +     +++i++  d+d +g +df e++ 
  EFC38616.1  86 KMGEIELKILLEEFRNASNEEGLLEKDNFFDVIKNTLSQKfdiQnsmpAFHRIYEAFDLDGNGAIDFVELAT 157
                 677899999999**********************964332111111225789***************99875 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.031
   EF-hand_4  42 edklekiwdladidedgkldfeefciam 69 
                 +d l  ++ l d++ dg++  ee++   
  EFC38616.1 168 KDILRFVFGLIDVNGDGSVQQEEMIDFF 195
                 6789999*************99987555 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00013
   EF-hand_4  41 eedklekiwdladidedgkldfeefcia 68 
                  ed l++ ++ +d+d++g+++f+ef+ a
  EFC38616.1 218 LEDYLSRTFTSTDLDQNGTIEFDEFVQA 245
                 47899********************965 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.7   3.7e+03      23      35 ..      87      99 ..      74     117 .. 0.63
   2 !    8.5   0.2    0.0008       1.8      34      48 ..     141     155 ..     138     162 .. 0.88
   3 !    8.5   0.4   0.00078       1.8      28      53 ..     171     196 ..     158     197 .. 0.85
   4 !   11.2   0.4   0.00011      0.25      36      52 ..     230     246 ..     226     248 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.7
   EF-hand_8 23 lseeevdilfref 35
                ++e e+ il+ ef
  EFC38616.1 87 MGEIELKILLEEF 99
                5555555554443 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0008
   EF-hand_8  34 efDtdgdGkisfeEF 48 
                 +fD+dg+G+i+f E 
  EFC38616.1 141 AFDLDGNGAIDFVEL 155
                 79**********886 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00078
   EF-hand_8  28 vdilfrefDtdgdGkisfeEFcvlle 53 
                 ++ +f ++D +gdG + +eE ++++ 
  EFC38616.1 171 LRFVFGLIDVNGDGSVQQEEMIDFFR 196
                 7889999*************999986 PP

  == domain 4  score: 11.2 bits;  conditional E-value: 0.00011
   EF-hand_8  36 DtdgdGkisfeEFcvll 52 
                 D+d++G+i f+EF++ +
  EFC38616.1 230 DLDQNGTIEFDEFVQAV 246
                 9************9987 PP

>> Dockerin_1  Dockerin type I domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.049   1.1e+02      18      46 ..     118     151 ..     115     157 .. 0.74
   2 ?    6.3   0.0    0.0049        11       3      11 ..     179     187 ..     177     191 .. 0.66
   3 ?   -1.8   0.0       1.7   3.8e+03      36      45 ..     228     237 ..     222     239 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.049
                 HHHHCT.....SSEBTTSCCCHGGGSTT-SSCES CS
  Dockerin_1  18 iinyln.....qregqssssngkaaDvNgDGrvn 46 
                 i+n l      q++ +  +   +a+D++g+G ++
  EFC38616.1 118 IKNTLSqkfdiQNSMPAFHRIYEAFDLDGNGAID 151
                 6666667777777777777778899999999998 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0049
                 ETTSSSC-S CS
  Dockerin_1   3 DVNgDgkVn 11 
                 DVNgDg+V+
  EFC38616.1 179 DVNGDGSVQ 187
                 666666664 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.7
                 GGSTT-SSCE CS
  Dockerin_1  36 aaDvNgDGrv 45 
                  +D++++G++
  EFC38616.1 228 STDLDQNGTI 237
                 5777777776 PP

>> TMEM214  TMEM214, C-terminal, caspase 4 activator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.2      0.51   1.1e+03     403     459 ..      28      84 ..      25      88 .. 0.73
   2 ?    8.9   0.1    0.0002      0.46     291     329 ..      94     132 ..      89     147 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.51
     TMEM214 403 qSsLLLkailksweslskklkskslketvqslkvtneelkkskksedldeckkvcqs 459
                  S +LL  + +s +  ++kl + +  +t+ +   t  e+ ++ + ++ + +k + +s
  EFC38616.1  28 SSEMLLADLMNSKRRAKPKLSTLQATNTLDDSGDTMSECGSTCSASTTSLTKDLTKS 84 
                 688999999999999999999888888888887777777776666555555555555 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.0002
     TMEM214 291 rllllhanltkgfgllnpkeffplldaafmpknnlsksl 329
                  ll +  n ++++gll++++ff++++++ ++k+++++s+
  EFC38616.1  94 ILLEEFRNASNEEGLLEKDNFFDVIKNTLSQKFDIQNSM 132
                 5788889999***********************988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       725  (0.0404373); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1845.05
//
Query:       EFC38617.1  [L=1510]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      9e-39  129.1  51.5    6.2e-07   28.9   0.4   10.3 10  MORN      MORN repeat


Domain annotation for each model (and alignments):
>> MORN  MORN repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.2   6.9e-05       1.2       1      20 [.    1246    1266 ..    1246    1268 .. 0.93
   2 !   25.0   1.0   6.2e-10   1.1e-05       1      23 []    1269    1291 ..    1269    1291 .. 0.97
   3 !    8.2   0.2   0.00013       2.4       1      21 [.    1292    1312 ..    1292    1314 .. 0.89
   4 !    4.3   0.1    0.0024        42       2      16 ..    1315    1329 ..    1314    1333 .. 0.82
   5 !   25.6   0.1     4e-10   7.2e-06       1      23 []    1338    1360 ..    1338    1360 .. 0.97
   6 !   17.5   1.4   1.5e-07    0.0026       1      21 [.    1361    1381 ..    1361    1383 .. 0.96
   7 !    7.7   0.0   0.00019       3.5       1      18 [.    1385    1402 ..    1385    1404 .. 0.90
   8 !   28.9   0.4   3.5e-11   6.2e-07       1      22 [.    1407    1428 ..    1407    1429 .. 0.97
   9 !   18.1   1.9   9.8e-08    0.0018       1      18 [.    1430    1447 ..    1430    1449 .. 0.93
  10 !   15.9   0.5   4.7e-07    0.0085       1      17 [.    1456    1472 ..    1456    1476 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 6.9e-05
        MORN    1 YeGeW.knGkrhGkGvytwpd 20  
                  Y+Ge  ++G+++GkG y  +d
  EFC38617.1 1246 YSGELdRKGQPNGKGFYKGSD 1266
                  999999***********9887 PP

  == domain 2  score: 25.0 bits;  conditional E-value: 6.2e-10
        MORN    1 YeGeWknGkrhGkGvytwpdGdr 23  
                  Y+G W+nGk+ G+G+  +pdG++
  EFC38617.1 1269 YDGSWVNGKKSGYGRIEYPDGSV 1291
                  9********************85 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00013
        MORN    1 YeGeWknGkrhGkGvytwpdG 21  
                  Y Ge  ++ rhG+G y  p+ 
  EFC38617.1 1292 YTGELLDDNRHGQGYYFTPNY 1312
                  99************9987775 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.0024
        MORN    2 eGeWknGkrhGkGvy 16  
                   G+W ++k++G+ + 
  EFC38617.1 1315 VGDWEKDKKNGQAII 1329
                  69*********9765 PP

  == domain 5  score: 25.6 bits;  conditional E-value: 4e-10
        MORN    1 YeGeWknGkrhGkGvytwpdGdr 23  
                  YeG++++++++GkG++t+ dG++
  EFC38617.1 1338 YEGNFVDNFPDGKGTFTFRDGSV 1360
                  *********************85 PP

  == domain 6  score: 17.5 bits;  conditional E-value: 1.5e-07
        MORN    1 YeGeWknGkrhGkGvytwpdG 21  
                  Y+Ge+ +G rhG G++t+ dG
  EFC38617.1 1361 YCGEFEKGCRHGEGTLTYGDG 1381
                  9*******************9 PP

  == domain 7  score: 7.7 bits;  conditional E-value: 0.00019
        MORN    1 YeGeWknGkrhGkGvytw 18  
                  YeGeW ++k  Gk + t+
  EFC38617.1 1385 YEGEWAKDKQTGKAIITY 1402
                  ************987766 PP

  == domain 8  score: 28.9 bits;  conditional E-value: 3.5e-11
        MORN    1 YeGeWknGkrhGkGvytwpdGd 22  
                  YeGe ++Gkr+G+G++t+++Gd
  EFC38617.1 1407 YEGEVVDGKRQGHGTFTYANGD 1428
                  *********************8 PP

  == domain 9  score: 18.1 bits;  conditional E-value: 9.8e-08
        MORN    1 YeGeWknGkrhGkGvytw 18  
                  Y+GeW+n++++GkG+y +
  EFC38617.1 1430 YDGEWVNDQKQGKGIYFF 1447
                  9***************66 PP

  == domain 10  score: 15.9 bits;  conditional E-value: 4.7e-07
        MORN    1 YeGeWknGkrhGkGvyt 17  
                  Y GeW +Gk+hG G++ 
  EFC38617.1 1456 YRGEWFKGKKHGVGILE 1472
                  99************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1510 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2083  (0.11618); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.43u 0.39s 00:00:01.81 Elapsed: 00:00:00.64
# Mc/sec: 7064.09
//
Query:       EFC38618.1  [L=846]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.4e-63  213.0   0.3    3.4e-63  213.0   0.3    2.5  2  DNA_ligase_A_M   ATP dependent DNA ligase domain
    1.5e-38  132.8   0.5    3.6e-38  131.6   0.5    1.7  1  DNA_ligase_A_N   DNA ligase N terminus
    3.4e-24   85.3   0.0    1.2e-23   83.5   0.0    2.0  1  DNA_ligase_A_C   ATP dependent DNA ligase C terminal region
    9.2e-06   26.1   0.1      2e-05   25.0   0.1    1.6  1  RNA_ligase       RNA ligase
  ------ inclusion threshold ------
      0.043   13.4   0.2      0.093   12.3   0.0    1.7  2  IU_nuc_hydro     Inosine-uridine preferring nucleoside hydrol
       0.09   12.8   0.4         13    5.9   0.0    2.6  2  DNA_ligase_OB_2  DNA ligase OB-like domain
        0.1   11.3   3.3       0.15   10.8   3.3    1.2  1  Presenilin       Presenilin
       0.23   10.9   7.8       0.52    9.8   7.8    1.6  1  Sec62            Translocation protein Sec62
        1.7    6.6  17.8        2.5    6.1  17.8    1.1  1  DUF5401          Family of unknown function (DUF5401)
        2.3    7.5  21.7          4    6.7  21.7    1.3  1  BUD22            BUD22


Domain annotation for each model (and alignments):
>> DNA_ligase_A_M  ATP dependent DNA ligase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.5      0.29   5.2e+02     102     157 ..      28      85 ..      20     113 .. 0.67
   2 !  213.0   0.3   1.9e-66   3.4e-63       1     204 []     474     678 ..     474     678 .. 0.99

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.29
                     CHCCTHHHHHHSEEEEEEEEEEEE.TTEEH.TT.SCHHHHHHHHHHHB--BTTTEEE-- CS
  DNA_ligase_A_M 102 kkkkveeklkeaelclfvFDiLyl.dgesl.td.eplkeRrklLeeilkesedrvelae 157
                     k+++v  k++ +    ++FD+L   +++++ t+  +  +R+klL +i  ++e+r  +++
      EFC38618.1  28 KNVHVTMKMNVSAFWDLLFDCLNQvNNVTVsTRiNETTSRQKLLLKIK-KNEKRTIFLD 85 
                     556677777777777789***953355554333245677888888887.5555555544 PP

  == domain 2  score: 213.0 bits;  conditional E-value: 1.9e-66
                     -EEEEEESCHHHHHHHTTTSEEEEEEEESSEEEEEEE.ETTEEEEEETTS-B-GGGCHHHHHHHHHHBSTTESEEEEEEEEEEEETTTTCBEHHH CS
  DNA_ligase_A_M   1 pmLAeslksiekalkkleekafivEiKyDGeRaqvhk.egdkvklfSRrlkditaakpelvkalkeafkkdeksvilDGElvavdketgeilpfq 94 
                     pmLA+s+k +++++++++ek+f++E KyDGeRaq+h+  ++++k+fSR++++ t+++p+l+++l +  k+++ks+i+D+E+va+d+ +++i pfq
      EFC38618.1 474 PMLAKSAKGVQELFDRFGEKEFTCEFKYDGERAQIHMlPDKSIKIFSRNMENHTSKYPDLIQMLPQVTKEHVKSFIIDCEVVAFDPIEKKIKPFQ 568
                     9***********************************999******************************************************** PP

                     HHCHHHHCHCCTHHHHHHSEEEEEEEEEEEETTEEHTTSCHHHHHHHHHHHB--BTTTEEE--EEEESSHHHHHHHHHHHHHTTECEEEEEE..T CS
  DNA_ligase_A_M  95 klasrkkkkkkveeklkeaelclfvFDiLyldgesltdeplkeRrklLeeilkesedrvelaeslevkdveeleelleeaiseglEGlvvKn..p 187
                     +l++r +k+ +++++  ++++clf+FDiLy++ges ++++lkeRr +L++ +  s+d++ +a +++++d+++++ +le +i+ ++EGl+vK+  +
      EFC38618.1 569 VLSTRGRKNININDI--KVQVCLFAFDILYINGESCLKKNLKERRGILHDSFATSDDKFMFASHRDTNDLNDIQVFLEDSIKGNCEGLMVKTleV 661
                     ***************..***************************************************************************999 PP

                     T-CC-TTCEEEEEEEEE CS
  DNA_ligase_A_M 188 dskYepgkrsknwlKvK 204
                     d++Yep+krs nwlK+K
      EFC38618.1 662 DATYEPSKRSFNWLKLK 678
                     ***************99 PP

>> DNA_ligase_A_N  DNA ligase N terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.6   0.5     2e-41   3.6e-38       1     172 [.     234     409 ..     234     410 .. 0.97

  Alignments for each domain:
  == domain 1  score: 131.6 bits;  conditional E-value: 2e-41
                     BCHHHHHHHHHHCC.---HHHHHHHHHHHHHTS-..SHHHHHHHHHH....SS-CCCS------HHHHHHHHHHHHT--HHHHHHHHHHHS-HHH CS
  DNA_ligase_A_N   1 pFaelaelfekieestkkrlekrailanffrkvesagpedlypalrL....llPdydgreygigesllakalaealglskkkikdalakvgDlge 91 
                     p+  la+++++i++   + ++k+++l+n+fr++++++p+dl+  ++L    l+P++ g+e+g+gesl++kalaea+g + kkik+ + k gDlg 
      EFC38618.1 234 PYLFLAKTLDEISK-IGSSIKKTELLCNCFRSIIATSPSDLLYSVYLsinkLAPSHFGIELGVGESLIMKALAEATGKTLKKIKELSVKEGDLGL 327
                     577899********.777899**********************************************************999****9999***** PP

                     HHHHHHCCHHHH------BHHHHHHHHHHHHH-.STTHHHHHHHHHHHHHHHS-HHHHHHHHHHHCT---SS--HHHHHHHH CS
  DNA_ligase_A_N  92 vaeevlskrstlakkspltieevnelLdklaaa.gkgsedekkkilkkllkraspeEakyliriilkdlriglsektvldal 172
                     va  ++s+++t++k+++lt++ v+++++ +a++ gk+s+++k++ +k ll ++   E +++ir ++++lrigl+e+tvl al
      EFC38618.1 328 VANVARSTQKTMFKPKSLTLKSVYDSFKFIATTeGKKSMNTKVEKIKLLLVSSVDVEPMFIIRSLQGKLRIGLGEETVLIAL 409
                     *******************************999*******************99************************998 PP

>> DNA_ligase_A_C  ATP dependent DNA ligase C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.5   0.0   6.7e-27   1.2e-23       1      99 []     703     814 ..     703     814 .. 0.95

  Alignments for each domain:
  == domain 1  score: 83.5 bits;  conditional E-value: 6.7e-27
                     GGGSEEEEEEEEEE..TTEEEEEEEE-SS--HHHHHHHHHHHGGGEECTTCESS---HHHHTTEEE-TT-EEEEEESEEECTSSSTT........ CS
  DNA_ligase_A_C   1 rgglvgslllgvyd..dgkleyvgkvgtGfsdaeleelrkklkelerkkppfaekvpeeekrdvWvePelvveVkfaeitasgkyka........ 85 
                     r+g++g +ll++ d  ++++++++k+gtGfsd++l+e ++k++e+  + p+   +  e++++dvW++ ++v+e+k+a++t s+++ a        
      EFC38618.1 703 RTGVYGGFLLACFDpeSDQYQSICKIGTGFSDEMLKECADKMNEHIISAPKSYFSFRESQRPDVWFDANVVWEIKAADLTISPAHMAaiglvdes 797
                     6899***********9999***********************988888888778888888999***********************9******** PP

                     ...EECT-EEEEE-TTS CS
  DNA_ligase_A_C  86 ...slRfPrfkrlReDk 99 
                        +lRfPrf+r ReDk
      EFC38618.1 798 kgiALRFPRFVRTREDK 814
                     ****************8 PP

>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.1   1.1e-08     2e-05       2     160 ..     494     677 ..     493     678 .. 0.61

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 1.1e-08
                 EEEEEEE-SSEEEEEEEETT..EEEEETTCEBCTTTHHHHHHTHHHHHHHHHHHHH....ECCEEEEEEEES......SS...TTSS............ CS
  RNA_ligase   2 evvvtEKlDGtnfriylvke..vgvasRsqilpfgeekfkefkrwaaalrkklkekla..neelilyGElig.....hsi.kygglpk........... 79 
                 e+ ++ K DG++++i++ ++  ++++sR+ + +         + ++ +l + l++  +  ++++i+ +E++      ++i +                 
  EFC38618.1 494 EFTCEFKYDGERAQIHMLPDksIKIFSRNMENH---------TSKYPDLIQMLPQVTKehVKSFIIDCEVVAfdpieKKIkP-----Fqvlstrgrkni 578
                 889999************7678*******9993.........344555556666665578889*********9444422241.....234444566678 PP

                 .........EEEEEEEEEEECTT.............BECE--HHHHHHHHHCCTB..EEEEE.SSHHHHHCCC..........H.HHHTC--EEEEEES CS
  RNA_ligase  80 .........efyvFdifdirdke.............eqrylspdevealakglgtvpvlyegkflaaeellel.........ll.skgnkrEGlVikpe 146
                           +++Fdi+ i+++              ++ + + d            +++ +       +++++         l+ s ++++EGl +k+ 
  EFC38618.1 579 nindikvqvCLFAFDILYINGESclkknlkerrgilHDSFATSD-----------DKFMFA-------SHRDTndlndiqvfLEdSIKGNCEGLMVKTL 659
                 88888888899*******99333333334433333311111111...........122222.......2222223344465322455669*****9987 PP

                 ..SSSBE.TTE.BSEEEE CS
  RNA_ligase 147 ..selyk.nkg.raifKv 160
                   +++y+  k+  +++K+
  EFC38618.1 660 evDATYEpSKRsFNWLKL 677
                 556666666666777776 PP

>> IU_nuc_hydro  Inosine-uridine preferring nucleoside hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   5.2e-05     0.093     264     305 .]       1      43 [.       1      43 [. 0.96
   2 ?   -4.0   0.0       4.8   8.5e+03     167     196 ..     769     794 ..     764     834 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.2e-05
                   EEEEEESSSSTTTTEEEEETSTT.TTS--EEEEEEE-HHHHHH CS
  IU_nuc_hydro 264 lavdveleggltrGrtvvdlrrl.kkaknvkvatevdverfle 305
                   ++vd+e++++ + Grtv+d  +  + +knv+v ++++v +f++
    EFC38618.1   1 MRVDIECNSRFCDGRTVCDIYHMtNLPKNVHVTMKMNVSAFWD 43 
                   589******************999*****************96 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 4.8
                   -HHHHHSHHHHHHHHHTS-E.EEEE-HHHH CS
  IU_nuc_hydro 167 EfNifvDPeAAkiVlesapvkitlvpldvt 196
                   ++N+++  +AA+ ++   p    ++ + + 
    EFC38618.1 769 DANVVWEIKAADLTI--SPA--HMAAIGLV 794
                   789999999999998..355..44444433 PP

>> DNA_ligase_OB_2  DNA ligase OB-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0    0.0073        13       2      35 ..     699     738 ..     698     752 .. 0.69
   2 ?    4.4   0.1     0.022        39      53      66 .]     797     811 ..     794     811 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0073
                      ...EEEEEEEEEEEEE...TTEE....EEE-SS--HHHHH CS
  DNA_ligase_OB_2   2 GkGkykgmlGallvetk..kgkr....fkiGsGlsdaqRe 35 
                      G+Gk  g+ G +l      + ++     kiG+G+sd+  +
       EFC38618.1 699 GRGKRTGVYGGFLLACFdpESDQyqsiCKIGTGFSDEMLK 738
                      8999999999888766412322223459********9755 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.022
                      SSSS.-EEEEEEEE- CS
  DNA_ligase_OB_2  53 skgv.pRfPsflrvR 66 
                      skg+ +RfP+f+r R
       EFC38618.1 797 SKGIaLRFPRFVRTR 811
                      566669*******98 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   3.3   8.3e-05      0.15     236     309 ..     109     182 ..      68     297 .. 0.49

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 8.3e-05
  Presenilin 236 eeeeeaekkkeeasesskeeeseeesseksaqsse.......seeeseeesseaessaeesseekeseessesseeeeeee 309
                 ++++e++k+++e+++++ e+++e+++        +       +e+ +eee++++++  +++s ++++ee+++++e eee++
  EFC38618.1 109 SQQTEKRKRNDEERKEKVEQSDETKKR-------KiiddeidDETIEEEEEEKTSTLMDTTSYSSDEEEEEDHDEIEEEND 182
                 111111111111111111111111111.......01111122111111111111111112221111112222211111111 PP

>> Sec62  Translocation protein Sec62
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   7.8   0.00029      0.52       8     122 ..     112     226 ..      92     234 .. 0.52

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00029
       Sec62   8 akkvvralksekekkkskkkkeklkevkkkekaekvfkelkksqlalrveklkekekkkkkeekkkkkkkkkkvkleieeeqefvddnevYvW.iYepk 105
                 ++k +r+ +++kek +++++++k k ++++ + +++ +e++++++++ +++++ +++++++e++++ +++ + v+ +++++ +  ++   Y +  Y+p+
  EFC38618.1 112 TEKRKRNDEERKEKVEQSDETKKRKIIDDEID-DETIEEEEEEKTSTLMDTTSYSSDEEEEEDHDEIEEENDSVSCKVSTSVKKNSKAPNYEYnSYDPI 209
                 33334444444444444444433444444333.33344444444444444444444444444445555555555555544444433444444317**** PP

       Sec62 106 qlktlligllvvvaila 122
                    t+ +g   v+++l+
  EFC38618.1 210 ASATWKTGNRFVFTTLI 226
                 ***99999988887766 PP

>> DUF5401  Family of unknown function (DUF5401)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1  17.8    0.0014       2.5     463     551 ..      90     181 ..      54     202 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0014
     DUF5401 463 rlrqqeeerkrkkl...elekekrekkeaeeerrkilekeleerkqalieeerkrkllekemeerqkaiyeeeerrkaeeerrkqkeleerr 551
                  l q  + rk++ +   +  ++ +++k+ +eer+  +e+  e +k+++i++e     +e e ee+ +++++       eee   + e+ee +
  EFC38618.1  90 NLEQSHNYRKNRSFfgsKNSQQTEKRKRNDEERKEKVEQSDETKKRKIIDDEIDDETIEEEEEEKTSTLMDTTSYSSDEEEEEDHDEIEEEN 181
                 456666666665542213345567788999999999****************************************************9865 PP

>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7  21.7    0.0023         4     117     253 ..      54     193 ..      49     216 .. 0.41

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0023
       BUD22 117 sktvkevveeivesvkkllgiekkkkkkeeekkkkkkkkkkkkkkeeee....eeesdkeeesedsedeekeeseddeeeeeededdedaeedeedeea 211
                 + tv+++++e  +  k ll+i+k ++k++   + + ++ +++ + ++++     ++s++ e+++ +++e ke+ e+++e+++ +  d++ ++ e  ee+
  EFC38618.1  54 NVTVSTRINETTSRQKLLLKIKK-NEKRTIFLDVSFTNLEQSHNYRKNRsffgSKNSQQTEKRKRNDEERKEKVEQSDETKKRKIIDDEIDD-ETIEEE 150
                 55666666666666666666666.22222222222222222222222223554222222222222222234444444444444444444443.344445 PP

       BUD22 212 eerelaqydg.llasddededeyneetdeesseesdssdsses 253
                 ee++++ + +    s+de+e+e+++e +ee+++ s + ++s +
  EFC38618.1 151 EEEKTSTLMDtTSYSSDEEEEEDHDEIEEENDSVSCKVSTSVK 193
                 5555555555233466666662222222222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (846 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2253  (0.125662); expected 358.6 (0.02)
Passed bias filter:                      675  (0.0376485); expected 358.6 (0.02)
Passed Vit filter:                        91  (0.00507558); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.94u 0.31s 00:00:01.25 Elapsed: 00:00:00.50
# Mc/sec: 5136.64
//
Query:       EFC38619.1  [L=1130]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-52  179.4   8.8    1.7e-52  179.1   7.1    2.1  2  rRNA_proc-arch  rRNA-processing arch domain
    1.5e-48  164.6   0.7    4.6e-48  163.0   0.7    1.9  1  DSHCT           DSHCT (NUC185) domain
    6.8e-19   68.3   0.0    2.2e-18   66.7   0.0    1.9  1  DEAD            DEAD/DEAH box helicase
    1.1e-07   32.1   0.0    1.7e-06   28.3   0.0    2.7  1  Helicase_C      Helicase conserved C-terminal domain
    7.4e-05   22.8   0.0    0.00025   21.1   0.0    2.0  1  ResIII          Type III restriction enzyme, res subunit
  ------ inclusion threshold ------
      0.025   14.8   0.0       0.11   12.7   0.0    2.1  2  AAA_22          AAA domain
      0.033   14.1   1.3        0.3   11.0   0.0    2.9  3  ATPase_2        ATPase domain predominantly from Archaea
       0.13   11.3   0.6       0.44    9.6   0.0    2.0  2  T2SSE           Type II/IV secretion system protein


Domain annotation for each model (and alignments):
>> rRNA_proc-arch  rRNA-processing arch domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.5   3.4e+03      86     133 ..     429     483 ..     420     503 .. 0.60
   2 !  179.1   7.1   7.4e-56   1.7e-52       1     269 [.     629     923 ..     629     924 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.5
                     TEEEEEEEEEEEEE-...SSS....T.TB-..--TCTT.EEEEEEEEEEETTS-GGG- CS
  rRNA_proc-arch  86 dldfgwGivlnfkkr...nkn....skeee..asdees.yvVdvllvlsenskrkded 133
                     + +f+  iv +f+++     +    s + +  +++ee+ +v +v+ +  ++ +++d++
      EFC38619.1 429 KRNFQPVIVFSFSRKeceT-RavslS-K-SnfNDEEEMsLVAEVFNNAIDSLSDEDRK 483
                     4567777888887333431.134322.2.23567777778888887777666554444 PP

  == domain 2  score: 179.1 bits;  conditional E-value: 7.4e-56
                     HHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHTC--TTHHHHHHHHHHHHHHHHHHHHHHHHHCSHHHHGGG--TTEEEEEEETTTEEEEEEEEE CS
  rRNA_proc-arch   1 EyMlerSFsqfqnqkslpelekklkeleeelksitiedeedieeyyklrqqleelreeirkiltkpknilpfLqpGRlvrvksnddldfgwGivl 95 
                     Ey++erSF+q+q++k+  + e+ l+e+  +++s++ie+e ++++yy+++++le+  +++rk++t+pk+++p+L++GRl+r++  +   fgwGi++
      EFC38619.1 629 EYIMERSFFQYQSEKKRLAFEQTLNETIVKRDSMKIENEPQLSSYYNMKKELENEYNNLRKLITTPKYSIPVLSAGRLLRIN--G---FGWGILI 718
                     9********************************************************************************7..5...******* PP

                     EEEE-SSST.TB-...--TCTT.EEEEEEEEEEETTS-GGG--TT--S--TT--B-TT..S-EEEEEEEEEGGGEEEEEEEEE---SSTTST... CS
  rRNA_proc-arch  96 nfkkrnknskeee...asdees.yvVdvllvlsenskrkdedgekseesaeelkPkagdrekgevevvpvplkcieaiSsvrlklpkdlrks... 183
                     +f+k+ k+  +e+   +++++s y++d+ll+ +++++++  +    +e++++l+P        ++ + +++++ ie+ Ssv+++l k+++++   
      EFC38619.1 719 KFTKK-KH--AEKlqiNQTKSSdYLIDILLPSHPDKPNEPYPV---KEYKKSLEP--------KPIIKTLSVDLIECYSSVKVYLSKEMKSRpda 799
                     **733.33..3333588888889************87754444...677888888........469**********************6533345 PP

                     ...THHHHHHHHHHHHHH......................HSS---B--TTTTS----HHHHHHHHHHHHHHHHHHTSGG.G.S........... CS
  rRNA_proc-arch 184 ...eareevakavqelkr......................rfpgiplldpikdmkikdeefkkllkkiealesrlaknpllh.s........... 241
                        ea++++ k +++++r                      ++  +p ld +++m+i   ++k++++ i++lesrl+ +p+++             
      EFC38619.1 800 nsgEAKSTILKLLETISRfksqpttettdgmmsidklsvyKYGDVPRLDLVEEMGIARAQVKNVVDTIQQLESRLSYSPFYQyElnasngnaskd 894
                     566999999999999999*****************999864459************************************986267878888765 PP

                     .SSHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  rRNA_proc-arch 242 .pnleelyalyekkvalqeeikelkkeis 269
                       n ++++al+e k ++++ei++lkk+i+
      EFC38619.1 895 dINYKNQIALFESKLEIENEIEALKKQIK 923
                     555************************98 PP

>> DSHCT  DSHCT (NUC185) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  163.0   0.7     2e-51   4.6e-48       1     164 []     950    1125 ..     950    1125 .. 0.94

  Alignments for each domain:
  == domain 1  score: 163.0 bits;  conditional E-value: 2e-51
       DSHCT    1 entvtlkGrvaaeirsedeLlltellfsgvlddlepeelaAllsalvfeekredeeeke.pklseeleealeelkeiaeriakvs............ 84  
                  +n++t+kGrva+e++s+d L++te++ +g+++dl+pe+++A+ls+++ e  ++++ +++ ++l +el++++eel+++a+r+a+vs            
  EFC38619.1  950 DNVITAKGRVACELSSADSLVITEMIYNGAFSDLTPEQCIAVLSCFASEVTSSQNRQDDkDALVDELKKPYEELEKAARRVAEVSieskleldtdky 1046
                  589**********************************************99888777664566999*******************999999998885 PP

       DSHCT   85 vesrldlglvevvyaWakgasfaellektdldeGdiVRllrrleellrqlakaakvigneeLkkkaeeaielikRdiVfa 164 
                  ++  +  +++++ +aW++ga+f +++++t+++eG+iVR++rr+ee++rq+  aak+ig+e+++kk+    e+++RdiVf+
  EFC38619.1 1047 LQ-SFPCNMMNLTFAWCNGAKFVDICKMTEIFEGSIVRSMRRCEEIVRQMCAAAKAIGEETIEKKLLIGLEKMRRDIVFS 1125
                  55.48899**********************************************************************95 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.7   0.0   9.6e-22   2.2e-18       3     171 ..     178     323 ..     176     327 .. 0.90

  Alignments for each domain:
  == domain 1  score: 66.7 bits;  conditional E-value: 9.6e-22
                 HHHHHHHHHHTTCEEEEEESTTSSHHHHHHHHHHHHHHHSTTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHHTTCSEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   3 iQaeaiplilgggdvlvaaeTGsGKTlaflipvlqivyetkgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskldngvdiv 101
                  Q++a+ +i   ++vlv+a+T +GKT+++  ++ +++     k+g ++++ +P ++L +q +++l++ +      v l++g+v+ + + s       ++
  EFC38619.1 178 FQRQAVRAIELSQSVLVSAHTSAGKTAVAEYAIAKSL-----KDGSRVIYTSPIKALSNQKFRELQEEFTD----VGLMTGDVTINPNSS-------CI 260
                 79********9***********************999.....89**********************99995....446788887755554.......56 PP

                 EEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTTSTTTSEEEEEESSBSH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD 102 vgtpgrlddllstgklnlsqvrflVlDEadrlldqgfsdfinrilnqlpqitcdgklqrqvivlSATlpk 171
                 v+t++ l ++l +g+  l++v+++++DE++ + d++++  +++ l  l       +++ + ++lSAT+p+
  EFC38619.1 261 VMTTEILRSMLYRGSEILNEVQWVIFDEVHYMRDKERGVVWEETLILL-------PNSVKYVFLSATMPN 323
                 ***********999988**************************99999.......56677********94 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.0   7.6e-10   1.7e-06      21     111 .]     469     574 ..     418     574 .. 0.80

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 7.6e-10
                 EEESSHHHHHH.......HHHHHHHTTSTEEEESTTSTHHHHHHHHHHHHTTSSSEEEESGGGTSSSTSTTESEEEESSSS.........SSHHHHHHH CS
  Helicase_C  21 ifvntidrlek.......vklllekkgikvavlhgelpqnereeileqfnkgesdvLiatdvaerGidipkvnlVinfdlp.........rnvtsyiqr 103
                 +f n id+l++       v+ +l   +  + v+h+ l    +e i   f++g ++vL at   ++G+++p +++V + ++           +  +yiq+
  EFC38619.1 469 VFNNAIDSLSDedrklpqVETMLPLLQKGIGVHHSGLLPIMKEVIEILFQEGLIKVLFATETFAMGLNMP-AKTVLFTGIEkydgqitrrLTSGEYIQM 566
                 7888888665554444443333222256677799999999999**************************9.99999999987665555433359***** PP

                 HTTSSSTT CS
  Helicase_C 104 iGRtgRag 111
                 +GR+gR g
  EFC38619.1 567 SGRAGRRG 574
                 ******75 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   1.1e-07   0.00025       4     169 ..     175     321 ..     172     323 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 1.1e-07
                 E-HHHHHHHHHHT......TTSEEEEEESTTSTHHHHH.HHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--..... CS
      ResIII   4 lreyQeeaienlleklkskrdkrglikmaTGtGKTlva.aklierllkkgkeekflflvprkslleqtleefkkflseaykeigkkvsgdkkkakekds 101
                 l   Q +a+++++        + +l+ + T +GKT va ++++++l+  g+  +++   p k+l +q  +e+++ + +      + ++gd  ++     
  EFC38619.1 175 LDAFQRQAVRAIEL------SQSVLVSAHTSAGKTAVAeYAIAKSLKD-GS--RVIYTSPIKALSNQKFRELQEEFTDV-----GLMTGDVTIN----- 254
                 56678888888863......4679**************6666666665.45..9*************999999988864.....7899999998..... PP

                 ..-SEEEEEHHHHHHTH........HHHTTT-SEEEEETGGGTTS.T...TTHHHHHT-.--SEEEEEESS- CS
      ResIII 102 tnkkilvttiqsldadseeeeeeseellrdrfdviiiDEaHrlgakk...swreilekf.keavllglTATp 169
                  n++ +v+t++ l + +     ++ +   ++ + +i+DE+H +++k+    w+e l  + ++ + + l+AT+
  EFC38619.1 255 PNSSCIVMTTEILRSML-----YRGSEILNEVQWVIFDEVHYMRDKErgvVWEETLILLpNSVKYVFLSATM 321
                 899999********999.....89999999999************757889999543331557778889987 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   5.1e-05      0.11       6     128 ..     190     319 ..     186     327 .. 0.74
   2 ?   -2.6   0.0       2.8   6.2e+03      80     117 ..     569     607 ..     544     616 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.1e-05
      AAA_22   6 gilvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdllrellralglelka...........erlsseellealeqalraravie 93 
                 ++++v +++ +GKT +++    +  ++      +++v++  + +  s +++++   ++++++l +              ++e l+++l++ ++    ++
  EFC38619.1 190 QSVLVSAHTSAGKTAVAEYAIAKSLKD------GSRVIYTSPIKALSNQKFRELQEEFTDVGLMTgdvtinpnsscIVMTTEILRSMLYRGSEILNEVQ 282
                 5788999999*********99998765......8888877777777888887777777777777799999666666566666666666666666666** PP

      AAA_22  94 lliiDEaqhlr...s.eealeeLrsllnlsrkgvqliLv 128
                  +i DE++++r   +     e+L  l n  + +  ++ +
  EFC38619.1 283 WVIFDEVHYMRdkeRgVVWEETLILLPN--SVKYVFLSA 319
                 **********886425777777788888..655555555 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.8
      AAA_22  80 ealeqalraravielliiDEaqhlrs...eealeeLrslln 117
                 +a ++ l++++  ++li D+ +   +   +++++ + ++ln
  EFC38619.1 569 RAGRRGLDDKGI-VILIMDDPDLR-EedaKQLMNGIADCLN 607
                 344444555555.99999998876.2244777777777777 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00013       0.3      30      74 ..     199     243 ..     189     303 .. 0.67
   2 ?    0.2   0.0      0.26   5.9e+02      82     124 ..     388     438 ..     351     481 .. 0.71
   3 ?   -3.2   0.1       2.9   6.6e+03     101     118 ..     910     927 ..     867     944 .. 0.54

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00013
    ATPase_2  30 gsGKtaLlkeiienledkdkyviyyialreesiskldefieeeee 74 
                 + GKta+   +i ++++ + +viy ++++  s++k++e  ee  +
  EFC38619.1 199 SAGKTAVAEYAIAKSLKDGSRVIYTSPIKALSNQKFRELQEEFTD 243
                 67***********************************99333332 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.26
    ATPase_2  82 l.........giavpkaeleeilk.eksklvfkaielllekikkkgkkiiiii 124
                           +   + ++  +++  +++k v+ ++ +l + i k+  +++i++
  EFC38619.1 388 SknvtsggsgS--GNVNSSGKVSGgDRKKRVDTSLVKLVNMIMKRNFQPVIVF 438
                 13445554321..222333455557889999999999********99999987 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.9
    ATPase_2 101 lvfkaielllekikkkgk 118
                 ++++ ie+l+++ik +g+
  EFC38619.1 910 EIENEIEALKKQIKTTGQ 927
                 224444444444444433 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00019      0.44      96     160 ..     155     221 ..     134     224 .. 0.71
   2 ?   -1.6   0.1      0.48   1.1e+03     154     197 ..     897     939 ..     889     941 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00019
       T2SSE  96 Rkksakeltlddlgaeealk.ekiaevlrkavrerglilvsGgTgsGKttll.yallkeinksderi 160
                  +k++ el l++ ++e  ++ +++++   +a++  +++lvs  T+ GKt ++ ya+ k +++ ++ i
  EFC38619.1 155 EQKTQVELGLKQAAKEYPFTlDAFQRQAVRAIELSQSVLVSAHTSAGKTAVAeYAIAKSLKDGSRVI 221
                 455566666665555433323666666666778899*************999788888888774444 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.48
       T2SSE 154 nksderivtvEDpvEiqle.ganqvqlnakkakvtfadllraaLR 197
                 n + ++i + E   Ei+ e +a + q+++  ++v +++ l++++R
  EFC38619.1 897 NYK-NQIALFESKLEIENEiEALKKQIKTT-GQVVMKEELKNMMR 939
                 544.88999999999988624455677777.99***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       919  (0.0512577); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.88u 0.33s 00:00:01.21 Elapsed: 00:00:00.54
# Mc/sec: 6348.45
//
Query:       EFC38620.1  [L=884]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.4e-97  325.7  26.3    1.6e-96  324.8  24.5    2.0  1  Cnd2      Condensin complex subunit 2
     0.0003   21.0   0.0     0.0018   18.4   0.0    2.4  1  CNDH2_N   Condensin II complex subunit CAP-H2 or CNDH2, N-ter
  ------ inclusion threshold ------
      0.077   13.2   0.1      0.077   13.2   0.1    4.0  5  CTU2      Cytoplasmic tRNA 2-thiolation protein 2


Domain annotation for each model (and alignments):
>> Cnd2  Condensin complex subunit 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  324.8  24.5  2.6e-100   1.6e-96      13     765 ..      58     866 ..      40     867 .. 0.65

  Alignments for each domain:
  == domain 1  score: 324.8 bits;  conditional E-value: 2.6e-100
        Cnd2  13 k.....iplNDDeaEkakrrksrqalheaqinqikaaatparrrksaaveeaassssprtPktpmkrvpilanfeewmklatdNKInakNsWnlaLIDy 106
                       ++ N+D++Ek ++r++r+    a+ + ++ a+   +r++   v++ +++s + +P        + + f +++kl+t+NKI++kN+W+l+L Dy
  EFC38620.1  58 FaptanLDINNDDEEKMNNRRKRKSVVPASSKFLAGAT---SRKS--GVHRPSTTSRHVSP------SELEELFMNCIKLSTENKITTKNAWELNLLDY 145
                 14455599****************96666655555433...3333..33443344455555......224555************************** PP

        Cnd2 107 fhdmsLLkegds.vNFqkAsctLDgcvKIYtsRVDSvatetgkllsgLadstekkkkdneeeedeeegdeeeeeeegedgeekkkkkkKkqrsseatla 204
                 + ++  L  + +   Fq AsctLD++vKIY++RVDS++ et+k+l+  a+ +ek k          ++ e+++e +++d + ++k+kkK+ r   +tl+
  EFC38620.1 146 IGEV--LGSNLGgGTFQTASCTLDAGVKIYSTRVDSIHSETYKVLGSFARTQEKGKA---------DETENNQEGKDSDKS-EEKTKKKRVRYGVNTLE 232
                 ****..7666655*************************************9842222.........222222222223333.46789999********* PP

        Cnd2 205 ksfeslqlkklelefavDPLFkka...sAdfDeggakglLLNhLsidsegrivfDssddaedaa................sqteeeeeeeeeeedveid 284
                 ++++++++kkl+l+ ++ PL+      s +fD g+a +lLLN+L     ++++ Ds+    + +                +    eee ee+ +++ +d
  EFC38620.1 233 TNVNNITVKKLDLNYMIEPLYHNStgsSNNFDVGSAHSLLLNNLGLGLGCEVIIDSKSWDYKYSkiienipqqsvqpipfQ---VEEEVEEHANNITLD 328
                 *********************986222678**************************885554448*********9886541...444555555666666 PP

        Cnd2 285 lasLaa...........................rffpdlerleeldicps.lknfdlgdapsgsldipflkape....dwrqdkddleaed.elgdasg 350
                  +++++                            ++ + ++l++l+i p  + +++lg  ++g  di+++  +e    +     +++  ++ ++g +++
  EFC38620.1 329 KSTIKSfnnssmmedeeevnheqppplqseektSLVGESDQLQQLEINPNqHFDIELGGLETGIDDIQSMVPDEiaglN----MTQEIPHKiSIGCEGA 423
                 66666667777777777777777777777877778888999********624566699988888898888766643321....2222222223333333 PP

        Cnd2 351 illdd...........dnaagfdddddgllnafdlggdagfgeggeawareaalepq.dede.gevedndey..avslsrkqkkekveelrdilsyfdq 434
                  l++              +++ +dddd   + fd+   a+ + ++ +  ++ +  +  + +e +++++nd++   + + +k++++ + +  d  +yfd 
  EFC38620.1 424 ALINAvhevgglapdhFENVDHEDDDDDEGGLFDTD-FANPEPIETQTSDSGE--EIvTIEEkQKESENDKQlsFLDMLQKDPESLTVD--DDYAYFDV 517
                 343332212222221223333334444444555554.2233333222222211..1122222122222232212344444333322233..5566**** PP

        Cnd2 435 alqknWagPehWrirrikdvnkseeaakkkrkekepfeidFeapldesvaealftqassnsaislpkkqlkkksrnlLPddkhfnskqLlklflkPkar 533
                 +    W g +hW+   +   ++++++++kkr +ke+f+ dF ++ d+    + f+ +s+ ++ ++  k ++ ++ +lLP+d+h++  +Llk f  P + 
  EFC38620.1 518 TKIRHWSGIDHWKPTVKST-THTNKKTTKKRTQKEAFKFDFLTDCDKIDFATDFKISSKPEKNQMAEKSINAQKTTLLPEDFHYDLATLLKPFKLPPIF 615
                 *************776644.44455889999***************9999999999999999*******************************999998 PP

        Cnd2 534 lsrrkeeveegemdeafwakqkaeeeaa........kedeeapqGdyD.......anffadddglpfpqdlgggddddDddle.fada........... 605
                 ++r  ++v+ +e++ + +  +k+++           +      +G +        ++  +d+++ p++     ++  +D+dl+ f+             
  EFC38620.1 616 TNRSLKAVSINELGSQRFNFEKSKQPVVidtskrqkT-----TEGGMKvihssqlYDESDDENDQPMT-----EIGGFDMDLGgFDMItddltqpniep 704
                 8877455788999777666655555444655433320.....24555555422222223322222332.....22222222222111111123333333 PP

        Cnd2 606 .....rehfsp....................aag.aagatgltaelagleatagaeaklnetlafgstlvtqprrvrkeyvqYArvAKkvDvrrLKeel 678
                      +    +                    + + +++a+ l++++  ++++ +++ + + ++  g++l+++p++v k +++Y  +AK+vDvr LKe+l
  EFC38620.1 705 tieptT----EiimqdpnltyqtqqdtfqydTIKlNDSASLLDEKE--IQVA-TQNLNSTANTVGGEKLIEAPKKVSKLNIKYESKAKQVDVRALKEHL 796
                 444441....144445555555443333323222223333333333..2222.333445667889********************************** PP

        Cnd2 679 WklieeellesaaeeeesseeaakskekeekgalkFtevmnnLkkvypkq.....mmediStslaFiclLHLANEkgLklekqedledlkIr 765
                 Wk i  +  +                      +l+F++v++++++  pk+       ++ S++++Fic+LH  NE++L+le + d++d+ + 
  EFC38620.1 797 WKEIRSSDDK----------------------KLDFSSVVSTVNTTKPKEgerkpDFSEASIPFCFICMLHICNEQNLELEGRSDFSDFSVV 866
                 **99877664......................47888888888888887622222456899****************************996 PP

>> CNDH2_N  Condensin II complex subunit CAP-H2 or CNDH2, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   3.1e-07    0.0018      43     104 ..     159     220 ..     140     226 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.1e-07
     CNDH2_N  43 FaeAaLliqgsavvYsrKveyLyslvyqtlellskkkkkkqkesesekgededaeaaeaeee 104
                 F  A+  +   +++Ys +v+ ++s +y++l   +++++k +++++++++e +d++++e++++
  EFC38620.1 159 FQTASCTLDAGVKIYSTRVDSIHSETYKVLGSFARTQEKGKADETENNQEGKDSDKSEEKTK 220
                 88999999***********************9988888555555554444444333333332 PP

>> CTU2  Cytoplasmic tRNA 2-thiolation protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.6       1.4   8.5e+03      60      79 ..      31      50 ..       7      82 .. 0.58
   2 ?   -0.0   0.2      0.17     1e+03      78     100 ..     198     218 ..     161     238 .. 0.55
   3 ?   -3.5   0.4         2   1.2e+04      63      80 ..     329     346 ..     314     369 .. 0.47
   4 ?   -2.6   0.1       1.1   6.6e+03      65      80 ..     532     547 ..     524     562 .. 0.52
   5 ?   13.2   0.1   1.3e-05     0.077      16      80 ..     809     872 ..     804     884 .] 0.72

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.4
        CTU2 60 kewkrtitiselseteseee 79
                +++  +iti++ ++  ++++
  EFC38620.1 31 RNSTGSITIESPAPVRQNQS 50
                33444455555444444444 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.17
        CTU2  78 eekeelekakeeeeeeaeeeela 100
                  + +e+e+++e ++++  ++e++
  EFC38620.1 198 GKADETENNQEGKDSD--KSEEK 218
                 1111111111111111..11111 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 2
        CTU2  63 krtitiselseteseeek 80 
                 k+ti+  ++s++ ++ee+
  EFC38620.1 329 KSTIKSFNNSSMMEDEEE 346
                 333333333333333221 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 1.1
        CTU2  65 titiselseteseeek 80 
                 t++ +++ ++++++++
  EFC38620.1 532 TVKSTTHTNKKTTKKR 547
                 4444433333333332 PP

  == domain 5  score: 13.2 bits;  conditional E-value: 1.3e-05
        CTU2  16 dfpstvstvvrTgeKLvknksseeaeletsekCalCglpl.ddkakewkrtitiselseteseeek 80 
                 df+s+vstv+ T  K +++k +   +  +   C +C+l + ++++ e + +   s+ s  ++++++
  EFC38620.1 809 DFSSVVSTVNTTKPKEGERKPDF--SEASIPFCFICMLHIcNEQNLELEGRSDFSDFSVVKPKSNR 872
                 8***************9999875..4589***********65565566666666666655555553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (884 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1139  (0.0635284); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.50
# Mc/sec: 5274.42
//
Query:       EFC38621.1  [L=455]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.036   14.1   0.2       0.06   13.4   0.2    1.2  1  ORF6C     ORF6C domain


Domain annotation for each model (and alignments):
>> ORF6C  ORF6C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.2   3.3e-06      0.06      13      76 ..     358     419 ..     347     424 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.3e-06
       ORF6C  13 dekieeidervkkLeenmpldesekeeiqkkvkkkvvellggkkspaykdkslrkkvfsdiyrd 76 
                 +++ +  ++++++L++   + +s+  +i++  ++++  + +++++++ ++ +   +vfs +y++
  EFC38621.1 358 NQNFSSFEKQMEDLQQGDGIRSSQSDRIKRRKSRRINGVSEEENMSLIQEYN--GNVFSRLYHK 419
                 7888999*******************************************77..******9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (455 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       792  (0.0441742); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2803.90
//
Query:       EFC38622.1  [L=821]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-74  251.5  13.7    1.6e-74  251.5  13.7    2.3  2  RRN3      RNA polymerase I specific transcription initiation 
  ------ inclusion threshold ------
        9.2    5.2   9.7        1.3    8.1   0.8    2.2  2  AIP3      Actin interacting protein 3


Domain annotation for each model (and alignments):
>> RRN3  RNA polymerase I specific transcription initiation factor RRN3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  251.5  13.7   1.7e-78   1.6e-74       6     554 ..      16     618 ..      11     621 .. 0.77
   2 ?   -4.6   5.8      0.66   5.9e+03     217     256 ..     704     742 ..     669     759 .. 0.58

  Alignments for each domain:
  == domain 1  score: 251.5 bits;  conditional E-value: 1.7e-78
        RRN3   6 kmlkefVrnALeek.ekgdseqydeLleqfsekkeeseapslaelkqllkalssvvsrL.e...rshssLveailslkWlerdea.............. 85 
                 +++k+   +AL+e  e++d  +y +++++f++ +  +   + + l+ + + + +   +L +   +++++L++ails++   + ++              
  EFC38622.1  16 NVIKQAFSTALRELfENNDPRKYVSVVQKFHQLSPLQLVLTFKALSRITNEIVHS-RSLnNsqySNCKDLIHAILSTSTKVMCSNnkdlqisfdtlcla 113
                 5677888899999988999999999999999977666666666666655555554.3442322257999******995555555546877777777555 PP

        RRN3  86 ......fvkayieFlgeLvsaq......pkylsevlsklvqnfteqsess.aalpe..........ssevtrrevyerlHelLkkllsliPtla...sv 158
                                ++L+++        +  ++++s lv++f + ++ + ++++e            e  +r+  +++H+lL k+ +     +   + 
  EFC38622.1 114 lyttssS------TNSTLITTTnnnttaTSIHEMIISCLVEHFLPIPDFElKRIEEnngglkltaeLIETLERTRKQNVHNLLYKIQKKATNQHlfiTQ 206
                 4322111......22333333200000033344556666666666663333444446667777877444445556668999999999887765411166 PP

        RRN3 159 lqpllakkfPhkreskkaqvtYirnllklteycpelsedileliverlikiDVeiqveledlddeedeeleeeleededdedddeddeesdlddlssd. 256
                 l++ +++  Ph ++s + + ++++n l+l  y+p+l++ +++ +v+ li++D+++   ++  +d   +++++++ + +++         sd ++l++  
  EFC38622.1 207 LKDRIRQVYPHASHSLSIHRAFVDNALSLDRYIPSLTSFCFSSVVQSLIEMDAQLV-AMNSQNDTFSSQTNKHIGNMNNE--------ASDVKHLENAv 296
                 77889*************************************************95.68888888877777666553222........22333332220 PP

        RRN3 257 eeaeedeekdeeeeslkkikelvekLDailtllfehlek....................kfssestkeeeeeeeglelfntLlslFkstiLptyksrhv 335
                  + e de  +++e   +    ++ekLD+i+t+lfe++++                     ++s +++ + ++e  +++f++++ lF+s++L+ y+ +++
  EFC38622.1 297 FDFEFDE--SNAE---EMRIYCAEKLDSIVTILFEYINEranappsspvhlhpprqnnkYLESGNSEIKGKNEFLDSIFHSMMVLFRSFVLNQYQLHSI 390
                 1122222..1122...4456799****************9999999999988887777656666666666666777*********************** PP

        RRN3 336 qFllFhfssldpeladkflglLidialsknepaetRvaAaaYlaSfvaRAkfvskeqvrkvvslLvewlekyvdereeevqgpdlkrhkvFYavaQAll 434
                 qFl+F+++s++ +++++f+++L+  +++++ + e+R+  aaYl+  ++RAk+v+++ v +++  L++w eky+ ++e++ q  d+++h++FY+++Q ++
  EFC38622.1 391 QFLMFYVCSFHVNYMERFISFLLGNIFNSQLHVEVRKCCAAYLSGLLSRAKYVTNTIVLRTLGQLLAWSEKYIITFEQSLQYLDVETHSLFYSICQGVF 489
                 *************************************************************************************************** PP

        RRN3 435 YifCFRwrdLlkeeee...............kekdrkwlqelkvlqrviiskLnPLkvcspnVveeFakiaqalqllycysilesnkrerlsgieskst 518
                 Y++CF+ ++Llk e+                  + r++ ++  +++r+i+sk+nPLk++++ V+ee  +   +  l+ ++++le+n++  +   ++   
  EFC38622.1 490 YVLCFKIQQLLKPEDGeggetspirkdvkqlMAEGRQFFSQS-PIKRIIYSKFNPLKIVASDVAEEVVNAFSRFYLFDFHHVLEENQNIVV-PLRGGY- 585
                 ***********9887458999***999998744566666665.9********************************************844.444332. PP

        RRN3 519 akkkqeaaeLdsyFPFDPykLprskrfieelYveWs 554
                    + ++   + +FPFDPy L++s+++i ++Y +W+
  EFC38622.1 586 ---GGVNYLENNFFPFDPYLLRKSEKYILPIYQKWE 618
                 ...345555579***********************7 PP

  == domain 2  score: -4.6 bits;  conditional E-value: 0.66
        RRN3 217 ledlddeedeeleeelee.deddedddeddeesdlddlssd 256
                  e  d++e  ++++ + + +ed++++ +dd  s+ld+ +++
  EFC38622.1 704 PESYDEDEMMDDDNGIFDlSEDEQEEYNDD--SSLDSGDEE 742
                 455555555555555444222222222222..222222222 PP

>> AIP3  Actin interacting protein 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   2.5     0.016   1.5e+02      89     179 ..      12     102 ..       2     137 .. 0.66
   2 ?    8.1   0.8   0.00014       1.3      74     180 ..     175     297 ..     155     328 .. 0.62

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.016
                 XXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXX...........................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
        AIP3  89 skelkelkssiesqkaslqevserqeeaakekasesla..................kkelkaqlkevqslrrdLavlrqlysefkseikeslselreka 169
                 +++++ +k+++++  ++l                   +                    +l   +k ++++ +++   r l++++ s++k+ ++++ ++ 
  EFC38622.1  12 EQQINVIKQAFSTALRELF------------------EnndprkyvsvvqkfhqlsPLQLVLTFKALSRITNEIVHSRSLNNSQYSNCKDLIHAILSTS 92 
                 3444444444444333333..................033333333333333333367788899**********************************9 PP

                 XXXXXXXX.X CS
        AIP3 170 kkvkeaslas 179
                 +kv  ++ ++
  EFC38622.1  93 TKVMCSNNKD 102
                 9998444433 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00014
                 XXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXX.............................XXXXXXXXXXXXXXXXX CS
        AIP3  74 ldevkkhideslaslskelkelkssiesqkaslqevserqeeaakekasesla....................kkelkaqlkevqslrrdLavlrqlys 152
                 ++++++  ++++++l+ +++   ++ ++q+  ++++++r ++   ++++ sl+                    +   ++ ++++ ++  +L ++   ++
  EFC38622.1 175 IETLERTRKQNVHNLLYKIQ---KKATNQHLFITQLKDRIRQVYPHASH-SLSihrafvdnalsldryipsltSFCFSSVVQSLIEMDAQLVAMNSQND 269
                 44444444444444433333...33344444444444443333333332.22245667777777777887776666788899999************** PP

                 XXXXXXXXXXXXXXXXXXXXXXXXX.XX CS
        AIP3 153 efkseikeslselrekakkvkeaslast 180
                 +f+s++++ + +++++a++vk+++ a  
  EFC38622.1 270 TFSSQTNKHIGNMNNEASDVKHLENAVF 297
                 *********************4444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (821 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1277  (0.0712254); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.87u 0.32s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 4623.42
//
Query:       EFC38623.1  [L=390]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.1e-13   49.2   0.2    3.6e-12   46.4   0.2    2.2  1  PI31_Prot_N  PI31 proteasome regulator N-terminal
    1.6e-08   35.6  12.1    1.6e-08   35.6  12.1    2.7  3  PI31_Prot_C  PI31 proteasome regulator
  ------ inclusion threshold ------
       0.08   12.8   1.5       0.17   11.8   1.5    1.4  1  AAA_31       AAA domain


Domain annotation for each model (and alignments):
>> PI31_Prot_N  PI31 proteasome regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.4   0.2     6e-16   3.6e-12       7     159 ..      51     215 ..      46     218 .. 0.78

  Alignments for each domain:
  == domain 1  score: 46.4 bits;  conditional E-value: 6e-16
  PI31_Prot_N   7 ssydalallvHacmtalgFrlvglgedkkieesesksecqslapr.Lp.aeWnassdsysFrYaheqssmefvlkvdrlgnk.lvirgla...lgddk 98 
                  +++  l+l++H++m+++gFr+vgl+e ++        e  ++  + Lp +++ ++ + +s++Y+h+q   +f lkv  +g++ l++  +     + d 
   EFC38623.1  51 KPQTWLVLVLHFLMLKHGFRCVGLNETDQCV------ELPEG--QiLPpNNFDSNVEMFSLKYKHTQRTFNFTLKVLMMGQTkLLVFSTIllfPNIDI 140
                  677789********************98874......33222..1365156888**************************861555544456556667 PP

  PI31_Prot_N  99 iasfelavrdyvsssalPvrit..................g.edrsdlaeklkdvfiseerladLisllkvsivqklvpg 159
                    + +l+++ y ++++     +                  + ++  ++++ + d+  + ++l+dL  ++k++i +klvp+
   EFC38623.1 141 NENSNLNMSQYAKQQE-----EeqvyqlefnnlfefidreKfNEVINQSNDNIDFISVFKNLQDLEYQFKTQIQNKLVPK 215
                  7777888888887777.....1346778899******9983444444556789999**********************97 PP

>> PI31_Prot_C  PI31 proteasome regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       2.3   1.4e+04      14      18 ..     265     269 ..     244     285 .. 0.57
   2 !   35.6  12.1   2.6e-12   1.6e-08       1      78 []     290     353 ..     290     353 .. 0.74
   3 ?    1.1   0.5      0.15   9.2e+02      29      45 ..     358     374 ..     354     386 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.3
  PI31_Prot_C  14 hdPLr 18 
                  +dPLr
   EFC38623.1 265 FDPLR 269
                  26666 PP

  == domain 2  score: 35.6 bits;  conditional E-value: 2.6e-12
  PI31_Prot_C   1 iGdsDLyPpglgphdPLrgpgglpspgggdggggGmhvgpdhPlfkrsengpggrggpdgfelppavpPGARfDPvgp 78 
                  iGd+DLyP     ++P++g       g+g + ggG++vgp++Plf      pg++++      +p+++PGARfDP++p
   EFC38623.1 290 IGDEDLYPGLGHLPQPFGG---R---GSGFPFGGGSQVGPNNPLF----F-PGSNNNR-R--PNPGFIPGARFDPIYP 353
                  8*****9977777799663...2...2334679************....3.3344442.2..357***********98 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.15
  PI31_Prot_C  29 gdggggGmhvgpdhPlf 45 
                  g++g+gG ++ pdh   
   EFC38623.1 358 GGQGRGGGQPNPDHHRV 374
                  456899*******9655 PP

>> AAA_31  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.5   2.8e-05      0.17      36     114 ..     138     221 ..     119     224 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.8e-05
      AAA_31  36 vDlDpQanattglgiekneiektlyev.......lieeknikeaiiktkvenldlipssidLaeaeielvelekkeeilkellekv 114
                 +D+   +n+ ++ ++ k++ e+++y++       +i++++ +e+i+ ++++n+d+i    +L+++e ++ +  +++ + ke +e++
  EFC38623.1 138 IDINENSNLNMS-QYAKQQEEEQVYQLefnnlfeFIDREKFNEVIN-QSNDNIDFISVFKNLQDLEYQFKTQIQNKLVPKEGFETI 221
                 444444444443.346788888999985555443379*******99.667999*****************9999998888877766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (390 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1004  (0.0559987); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2257.77
//
Query:       EFC38624.1  [L=1228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-09   37.0   2.6      8e-09   35.9   2.6    1.6  1  GPS       GPCR proteolysis site, GPS, motif


Domain annotation for each model (and alignments):
>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9   2.6   4.5e-13     8e-09       3      45 .]     992    1050 ..     991    1050 .. 0.91

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 4.5e-13
         GPS    3 CvfWdeeneetgsWsteGCel....................tesdnknetvCsCnHLtsFAvL 45  
                  C fW   ne+t++Ws eGC++                     ++   n++ CsCnH+t FAvL
  EFC38624.1  992 CHFW---NETTEEWSKEGCTTvasysflgnskpkdslitddSNP-GLNRIYCSCNHTTLFAVL 1050
                  99**...7899********999****************885444.6799*************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       797  (0.0444531); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.93u 0.31s 00:00:01.24 Elapsed: 00:00:00.56
# Mc/sec: 6598.92
//
Query:       EFC38625.1  [L=661]
Description: phosphatidylinositol-4-phosphate 5-kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-33  115.9   1.7    2.6e-33  115.0   1.7    1.4  1  RhoGAP      RhoGAP domain
    1.3e-28   97.2  41.3    1.2e-06   28.1   1.3    8.5  8  MORN        MORN repeat
  ------ inclusion threshold ------
       0.28   10.3   2.6       0.73    8.9   2.6    1.7  1  MMU163      Mitochondrial protein up-regulated during meiosis
       0.57    9.6   2.5       0.75    9.2   0.3    2.1  2  LVIVD       LVIVD repeat
        1.7    8.5   6.0       0.65    9.9   1.5    2.1  2  Folliculin  Vesicle coat protein involved in Golgi to plasma 
          2    8.8   6.4         51    4.3   0.1    3.8  3  DUF3048_C   Protein of unknown function (DUF3048) C-terminal 


Domain annotation for each model (and alignments):
>> RhoGAP  RhoGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.0   1.7   8.7e-37   2.6e-33       1     148 [.     128     303 ..     128     307 .. 0.84

  Alignments for each domain:
  == domain 1  score: 115.0 bits;  conditional E-value: 8.7e-37
                 BHHHHHHHHHHHHHTTTSTTTTTS-S-HHHHHHHHHHHHHTGGGCT.......TTTTSCHHHHHHHHHHHHHHSSSTTTTGGHHHHHHHHHTS...... CS
      RhoGAP   1 PiivekcvefiekrgldtegiyRvsgskarvkelreafdkgkavds.......dleeedvhavaslLKrfLrelpepLltkelyeelieaaks...... 86 
                 P ++ + ++++ek+gl+t+gi+R s sk+r +++ +++d+  ++           e+ dvh  asl+K +Lr+l epLlt++lye+++++ k+      
  EFC38625.1 128 PQFLFHAMDYLEKHGLETQGIFRHSTSKSREEKVMKEIDELFKSGGakmatvdFNEYADVHLAASLIKVYLRKLREPLLTNKLYESFLATSKMinttsi 226
                 88999*********************998876666666665555445556998999********************************75555566666 PP

                 .....SSHHHH..............HHHHHHHHTTS-HHHHHHHHHHHHHHHHHHHTHHHH---HHHHHHHHHHHHHT-TS CS
      RhoGAP  87 .....edeeer..............lealkellekLPkenrdtLryLlehLkrvaenskenkMtaknLaivfaPtLlrpks 148
                      +    +               + l++++  LP++n+ +L+ L+ +L++v++++++n M+++n+aiv++P++l  k+
  EFC38625.1 227 snndtN----NlspseleeletsrkCQLLQQICGLLPRANYVLLKKLCLFLNTVSKKQQVNLMSPENIAIVIQPNILYLKD 303
                 654440....15566666666666699*************************************************98765 PP

>> MORN  MORN repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.8   2.1e-05     0.063       7      23 .]     446     462 ..     445     462 .. 0.93
   2 !   18.3   0.1     5e-07    0.0015       1      22 [.     463     484 ..     463     485 .. 0.97
   3 !   19.1   0.1   2.9e-07   0.00086       1      23 []     486     508 ..     486     508 .. 0.97
   4 !   10.4   0.0   0.00016      0.48       1      19 [.     509     527 ..     509     530 .. 0.95
   5 !   28.1   1.3   3.9e-10   1.2e-06       1      23 []     533     555 ..     533     555 .. 0.97
   6 !   13.5   1.1   1.7e-05     0.051       1      18 [.     556     573 ..     556     577 .. 0.91
   7 !   12.9   1.4   2.7e-05     0.081       1      17 [.     578     594 ..     578     595 .. 0.94
   8 !    6.5   0.3    0.0029       8.7       2      20 ..     603     621 ..     603     622 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.1e-05
        MORN   7 nGkrhGkGvytwpdGdr 23 
                 nG++hG+G++ + dG++
  EFC38625.1 446 NGQKHGFGILMYNDGGV 462
                 9**************85 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 5e-07
        MORN   1 YeGeWknGkrhGkGvytwpdGd 22 
                 YeG + +++r+G G++++ dG+
  EFC38625.1 463 YEGYFIDDMRDGAGKMVFTDGS 484
                 *********************8 PP

  == domain 3  score: 19.1 bits;  conditional E-value: 2.9e-07
        MORN   1 YeGeWknGkrhGkGvytwpdGdr 23 
                 YeGe++++   GkG+y +++Gd+
  EFC38625.1 486 YEGEFSKDSITGKGIYKYASGDV 508
                 *********************96 PP

  == domain 4  score: 10.4 bits;  conditional E-value: 0.00016
        MORN   1 YeGeWknGkrhGkGvytwp 19 
                 YeG++ n  + G G++ ++
  EFC38625.1 509 YEGHFINSIKSGRGKMKFA 527
                 ****************997 PP

  == domain 5  score: 28.1 bits;  conditional E-value: 3.9e-10
        MORN   1 YeGeWknGkrhGkGvytwpdGdr 23 
                 Y+GeW n+kr+G+G+  +p+Gd+
  EFC38625.1 533 YDGEWNNDKREGFGKQSYPNGDV 555
                 9********************96 PP

  == domain 6  score: 13.5 bits;  conditional E-value: 1.7e-05
        MORN   1 YeGeWknGkrhGkGvytw 18 
                 YeGeW +++ +G+G++  
  EFC38625.1 556 YEGEWLGDFSDGYGTFSS 573
                 ***************975 PP

  == domain 7  score: 12.9 bits;  conditional E-value: 2.7e-05
        MORN   1 YeGeWknGkrhGkGvyt 17 
                 Y G Wk+Gk++G G+++
  EFC38625.1 578 YVGYWKRGKFDGRGRFV 594
                 99************985 PP

  == domain 8  score: 6.5 bits;  conditional E-value: 0.0029
        MORN   2 eGeWknGkrhGkGvytwpd 20 
                 eG W++G+ +G  +yt + 
  EFC38625.1 603 EGYWVDGQIEGETHYTDAQ 621
                 8**********98777665 PP

>> MMU163  Mitochondrial protein up-regulated during meiosis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   2.6   0.00025      0.73     134     189 ..      56     113 ..      32     163 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00025
      MMU163 134 kkkeeggka.ekekveks.asskssksekskkeesksalssskegvnkglsvllggda 189
                 +++++g+++ +++k +k+ + s+s++s+++  +  ++++ ss++g+n gls++l  d+
  EFC38625.1  56 SSNNNGSTTtTRSKRKKNsTRSSSTSSSSQILNGGENSKGSSSTGINGGLSKILNQDT 113
                 23333333323333333303333344444455666788889999*********98876 PP

>> LVIVD  LVIVD repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   0.3   0.00025      0.75      12      40 ..     297     325 ..     291     327 .. 0.82
   2 ?   -0.6   0.1      0.29   8.6e+02      12      20 ..     575     583 ..     573     585 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00025
       LVIVD  12 nYaYvAdqdngLvIvDISNpSsptlkgsy 40 
                 n +Y  dqd  L+I DISN ++ + + ++
  EFC38625.1 297 NILYLKDQDPMLTIRDISNATNVIKSLIV 325
                 678999***************98877666 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.29
       LVIVD  12 nYaYvAdqd 20 
                 +Y+Yv+ ++
  EFC38625.1 575 GYTYVGYWK 583
                 8*****886 PP

>> Folliculin  Vesicle coat protein involved in Golgi to plasma membrane transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   1.5   0.00022      0.65      87     171 ..      29     115 ..      17     117 .. 0.62
   2 ?    0.0   0.2      0.22   6.7e+02      91     126 ..     330     371 ..     312     410 .. 0.58

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00022
  Folliculin  87 fiveafeklaaeiqalaeaelereskeeeassaassssa..lkadgsglsrregssfslsk.ekylrrsksklkarsLaelvgdediF 171
                  + ++++ +++e  ++++++ + es+ +++++ ++++ +  +++++s++s++++ss+++ + ++ ++ s+s+  + +L ++++++ i+
  EFC38625.1  29 ALYDQLQGMINEHDKQQQQHDDDESSCSSNNNGSTTT-TrsKRKKNSTRSSSTSSSSQILNgGENSKGSSSTGINGGLSKILNQDTIW 115
                 5667788888887777777777776644433333333.24444444444444444444444255566666666699999999999986 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.22
  Folliculin  91 afeklaaeiqalaeaelereskeeeassaassssa......l 126
                  fe+ +++iq+  e+++ +++ +++++ ++ +s        +
  EFC38625.1 330 IFEDGVSDIQTNDENTATSQTCNDQTEDEDLNSIGasttptV 371
                 588889999999999997777655544333332222333321 PP

>> DUF3048_C  Protein of unknown function (DUF3048) C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.1     0.017        51      69      99 ..     476     506 ..     454     511 .. 0.79
   2 ?    1.6   0.2      0.12   3.4e+02      65      90 ..     519     544 ..     500     559 .. 0.78
   3 ?    3.8   0.5     0.024        73      62     101 ..     585     624 ..     547     627 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.017
                 EEEEEETTEEEEEEEEE..ETTEEEEE.ETT CS
   DUF3048_C  69 egyvftnGkaieitWskesedgptkyydedG 99 
                   +vft+G  +e+++sk+s +g+  y +++G
  EFC38625.1 476 GKMVFTDGSKYEGEFSKDSITGKGIYKYASG 506
                 3589***************999988888777 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.12
                 SS-EEEEEEETTEEEEEEEEE..ETT CS
   DUF3048_C  65 tgsgegyvftnGkaieitWskesedg 90 
                  g g++ ++ n   ++++W++++++g
  EFC38625.1 519 SGRGKMKFAANQSHYDGEWNNDKREG 544
                 48999****************99875 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.024
                 EE-SS-EEEEEEETTEEEEEEEEE..ETTEEEEE.ETTEE CS
   DUF3048_C  62 idltgsgegyvftnGkaieitWskesedgptkyydedGke 101
                  ++ g g+ +++   +  e+ W   + +g t+y+d++G +
  EFC38625.1 585 GKFDGRGRFVLLDSKESLEGYWVDGQIEGETHYTDAQGRK 624
                 4555788888888888889999999999999999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (661 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1693  (0.094428); expected 358.6 (0.02)
Passed bias filter:                      752  (0.0419432); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.79u 0.35s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 3783.24
//
Query:       EFC38626.1  [L=264]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (264 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1047  (0.058397); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1527.90
//
Query:       EFC38627.1  [L=511]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.1e-17   61.7   3.7       0.11   13.4   0.1    6.7  6  WD40         WD domain, G-beta repeat
    1.2e-07   31.9   0.4        5.3    7.4   0.0    5.1  5  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    0.00015   21.7   2.2       0.26   11.3   0.1    4.6  5  BBS2_Mid     Ciliary BBSome complex subunit 2, middle region
     0.0028   17.4   0.2     0.0046   16.6   0.2    1.3  1  Hairpins     HrpZ
  ------ inclusion threshold ------
      0.037   14.0   0.3         35    4.6   0.0    3.8  4  PQQ          PQQ enzyme repeat


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0    0.0011       3.9      21      37 ..     146     162 ..     105     163 .. 0.67
   2 !   13.4   0.1     3e-05      0.11       2      29 ..     166     194 ..     165     203 .. 0.85
   3 !    9.9   0.0   0.00041       1.5      13      38 .]     228     254 ..     216     254 .. 0.73
   4 !    8.6   0.0   0.00099       3.5       3      38 .]     271     307 ..     269     307 .. 0.83
   5 !   12.8   0.0   4.9e-05      0.18       4      37 ..     327     363 ..     324     364 .. 0.82
   6 ?    3.3   0.0     0.049   1.8e+02       1      16 [.     368     383 ..     368     400 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0011
                 TSSEEEEEETTSEEEEE CS
        WD40  21 dgawlasGsdDgtvriW 37 
                 d  ++ ++s D+t+++W
  EFC38627.1 146 DDEFFYTSSLDKTIKVW 162
                 4555899999******* PP

  == domain 2  score: 13.4 bits;  conditional E-value: 3e-05
                 EEEEEEESS.SSEEEEEEETTSSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGs 29 
                 ++++tl+ H +++++l++s d++ l+sG+
  EFC38627.1 166 NNIQTLKDHkDWIRCLDTSCDNSTLLSGC 194
                 7899*****666***************97 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00041
                 EEEEE.EETTSSEEEEEETTSEEEEEE CS
        WD40  13 vtsla.fspdgawlasGsdDgtvriWd 38 
                 ++s+  ++++ +++ +Gs+Dg +r++d
  EFC38627.1 228 INSILcTNHSPSMFYTGSRDGYIRLYD 254
                 5555446777777889*********98 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.00099
                 EEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 ++ ++++H +  + l+  +d + l+s+++D  +r++d
  EFC38627.1 271 PIFKIKAHeGKMNQLQITKDDHHLLSSGRDSVIRLFD 307
                 56677899666899999999999999999******98 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 4.9e-05
                 EEEEESS..SS..EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   4 lrtltGH..ss..vtslafspdgawlasGsdDgtvriW 37 
                 ++++  H  +s  v+s+ f ++ +++++Gs+D++v+i+
  EFC38627.1 327 IQKYQDHkcKSynVSSC-FFDNEKYVLTGSEDNKVYIY 363
                 56788896544899777.99999**9**********98 PP

  == domain 6  score: 3.3 bits;  conditional E-value: 0.049
                 TEEEEEEESSSSEEEE CS
        WD40   1 gqclrtltGHssvtsl 16 
                 g++lrtl GH +v +l
  EFC38627.1 368 GKLLRTLNGHEGVVHL 383
                 689*******887777 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0015       5.3      43      92 .]      79     127 ..      48     129 .. 0.67
   2 ?    4.1   0.0     0.016        57      28      78 ..     160     216 ..     153     237 .. 0.79
   3 ?    0.1   0.0      0.28     1e+03      48      69 ..     236     257 ..     224     270 .. 0.78
   4 !    6.2   0.0    0.0036        13      28      69 ..     271     310 ..     259     327 .. 0.89
   5 !    7.0   0.0     0.002       7.2      45      81 ..     343     379 ..     325     390 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0015
  ANAPC4_WD40  43 sLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgWgen 92 
                  s++ ++  +++ava  ++e+ ll+ e+g+  +++++++ + vt +++++n
   EFC38627.1  79 SVSMNERKNVIAVANGKSELLLLN-EDGQKTKQFKTQHREIVTQIHFMDN 127
                  555566666777776666666665.7788888899888888999998765 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.016
  ANAPC4_WD40  28 rvwtl.....eedkedsevrsLaWkpdgklLavaysdgevrlldaesgk.vvhslsv 78 
                  +vw++     + ++++  +r+L  + d++ L  ++  g++  +d+++++ ++ +++ 
   EFC38627.1 160 KVWHGenniqTLKDHKDWIRCLDTSCDNSTLLSGCISGRIFGYDINKEHqILFQIQN 216
                  677776666656788899**************************9987515555554 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.28
  ANAPC4_WD40  48 pdgklLavaysdgevrlldaes 69 
                  ++ +++  +  dg +rl+d+ +
   EFC38627.1 236 HSPSMFYTGSRDGYIRLYDSRN 257
                  55567888999*******9976 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0036
  ANAPC4_WD40  28 rvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaes 69 
                   ++++  ++++++ ++L+  +d++ L  +  d+ +rl+d+ +
   EFC38627.1 271 PIFKI--KAHEGKMNQLQITKDDHHLLSSGRDSVIRLFDVRK 310
                  57777..89999***************************976 PP

  == domain 5  score: 7.0 bits;  conditional E-value: 0.002
  ANAPC4_WD40  45 aWkpdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                  ++  ++k    + +d++v +++  sgk++++l+ ++ 
   EFC38627.1 343 CFFDNEKYVLTGSEDNKVYIYEKDSGKLLRTLNGHEG 379
                  45678899999*******************9988776 PP

>> BBS2_Mid  Ciliary BBSome complex subunit 2, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.28     1e+03      48      90 ..      82     129 ..      74     135 .. 0.51
   2 ?    1.2   0.1       0.1   3.6e+02      48     104 ..     145     198 ..      89     202 .. 0.61
   3 ?    3.5   0.0     0.019        69      15      42 ..     241     268 ..     230     279 .. 0.75
   4 ?   -0.2   0.0      0.28     1e+03       6      31 ..     286     310 ..     281     320 .. 0.80
   5 !   11.3   0.1   7.3e-05      0.26      10      54 ..     346     393 ..     339     424 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.28
    BBS2_Mid  48 lekerfayaleNGtvgvy...ekkerlWrvkskne..vvalaayding 90 
                 +++++ ++a++NG   +    e  ++  + k++++  v++++++d n+
  EFC38627.1  82 MNERKNVIAVANGKSELLllnEDGQKTKQFKTQHReiVTQIHFMDNNK 129
                 555555566666653322111333444444444443355666666654 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.1
    BBS2_Mid  48 lekerfayaleNGtvgvyekkerlWrvksknevvalaaydingdgtkelivgwsnGk 104
                 +++e f ++    t++v+++++ +   k ++  +   + d++ ++++ l+ g+ +G+
  EFC38627.1 145 IDDEFFYTSSLDKTIKVWHGENNIQTLKDHKDWI--RCLDTS-CDNSTLLSGCISGR 198
                 3344444455556677777777666666666533..233333.33445666666665 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.019
    BBS2_Mid  15 Lvvgsddfeirvfkeeelvaeitetekv 42 
                    gs d  ir+++  +lv++ ++ ++ 
  EFC38627.1 241 FYTGSRDGYIRLYDSRNLVFNSNTGSNT 268
                 5579999999999999999988876654 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.28
    BBS2_Mid   6 dvdgdgeneLvvgsddfeirvfkeee 31 
                 ++++d +++L+ +  d  ir+f+  +
  EFC38627.1 286 QITKD-DHHLLSSGRDSVIRLFDVRK 310
                 56666.789999*********98665 PP

  == domain 5  score: 11.3 bits;  conditional E-value: 7.3e-05
    BBS2_Mid  10 dgeneLvvgsddfeirvfkee..elvaeitetekvvsla.rlekerfa 54 
                 d+e++++ gs+d+++ +++++  +l+++++ +e vv l+ +++++r++
  EFC38627.1 346 DNEKYVLTGSEDNKVYIYEKDsgKLLRTLNGHEGVVHLIlNINDNRLL 393
                 5679***************99778999999999998875378877754 PP

>> Hairpins  HrpZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.2   1.3e-06    0.0046      76     204 ..      28     155 ..       4     187 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.3e-06
    Hairpins  76 tegkqgaykkdvtdALdklige.kLgdnfgasaegglgsglGgkGlqelsggadqqdLgnqvltGlgksaLndlltesdssgrsFskdDrpllkeiaqF 173
                 ++ ++ ++++ v++++ + i++  L d++  ++  ++g+g G +G+ +   ++  ++  n +    gks L  ll e  +++++F+ + r ++++i +F
  EFC38627.1  28 SSSRNRGSTNSVQQSMRERIKKvALIDKLETAQVATIGKGNGNGGGEDCCFSVSMNERKNVIAVANGKSELL-LLNEDGQKTKQFKTQHREIVTQI-HF 124
                 5566667788888888776654378999999999899***********************9999999*9996.5555889999*************.7* PP

    Hairpins 174 mDdnpeqfgkpDsksWakeLkeDdgldgaet 204
                 mD+n+  +++   k+ +    +D+++   + 
  EFC38627.1 125 MDNNKHRLENDNRKTSTSHAIDDEFFYTSSL 155
                 ********99977776666667777665555 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.86   3.1e+03      12      30 ..      98     115 ..      87     116 .. 0.77
   2 ?    0.5   0.0      0.19   6.6e+02       6      18 ..     193     205 ..     189     205 .. 0.84
   3 ?    4.6   0.0    0.0097        35       4      18 ..     241     256 ..     238     257 .. 0.79
   4 ?    3.6   0.0      0.02        72       5      23 ..     352     371 ..     349     371 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.86
                 EEEEETTTCCEEEEEESSS CS
         PQQ  12 lyAlDadTGkvlWrfktgg 30 
                 l+ l+ ++G++  +fkt++
  EFC38627.1  98 LLLLN-EDGQKTKQFKTQH 115
                 56678.99999999*9997 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.19
                 EETTSEEEEEETT CS
         PQQ   6 gsadGylyAlDad 18 
                 g+  G+++ +D++
  EFC38627.1 193 GCISGRIFGYDIN 205
                 7999*******85 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.0097
                 EEE.ETTSEEEEEETT CS
         PQQ   4 ylg.sadGylyAlDad 18 
                 +++ s+dGy++ +D +
  EFC38627.1 241 FYTgSRDGYIRLYDSR 256
                 5555*********986 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.02
                 EE.ETTSEEEEEETTTCCEE CS
         PQQ   5 lg.sadGylyAlDadTGkvl 23 
                 l+ s d+++y +  d+Gk+l
  EFC38627.1 352 LTgSEDNKVYIYEKDSGKLL 371
                 45599*************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (511 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       972  (0.0542138); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 3095.39
//
Query:       EFC38628.1  [L=1328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.5e-14   53.9  59.9      9e-05   22.8   2.2    7.8  8  LRR_4           Leucine Rich repeats (2 copies)
    2.9e-10   39.8  45.6    3.2e-05   23.6   8.6    5.8  6  LRR_8           Leucine rich repeat
    9.3e-10   37.4   9.9    0.00055   19.5   0.1    3.6  3  IQ              IQ calmodulin-binding motif
    4.8e-08   32.7  24.2    9.8e-05   21.9   4.6    4.5  3  LRR_9           Leucine-rich repeat
  ------ inclusion threshold ------
       0.19   11.5   1.4       0.38   10.5   1.4    1.5  1  Adeno_E3_CR2    Adenovirus E3 region protein CR2
       0.77    9.9   6.1        2.1    8.5   6.1    1.7  1  Arch_flagellin  Archaebacterial flagellin
        1.1    8.7   5.5        2.2    7.8   5.5    1.4  1  SKG6            Transmembrane alpha-helix domain


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   5.6    0.0011       2.7       2      39 ..     382     418 ..     381     423 .. 0.88
   2 !   22.8   2.2   3.5e-08     9e-05       2      44 .]     427     468 ..     426     468 .. 0.94
   3 !   20.2   1.0   2.2e-07   0.00057       2      39 ..     471     507 ..     470     512 .. 0.86
   4 !   12.4   0.7   6.3e-05      0.16       3      39 ..     517     551 ..     516     554 .. 0.87
   5 !   14.4   7.3   1.5e-05     0.039       3      44 .]     538     579 ..     536     579 .. 0.88
   6 !   15.3   0.9   7.9e-06      0.02       2      36 ..     582     618 ..     581     621 .. 0.85
   7 ?   -3.1   0.1         5   1.3e+04      21      29 ..     630     639 ..     626     648 .. 0.70
   8 ?   -2.2   1.3       2.5   6.4e+03      11      28 ..    1006    1022 ..     996    1031 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0011
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdl 39 
                 nL+ L L  N l++++ l++l +L+ L+L++N ++t++
  EFC38628.1 382 NLRALFLDTNVLQSLGTLKNLNQLECLSLNDN-RLTSI 418
                 89999999669******************666.99988 PP

  == domain 2  score: 22.8 bits;  conditional E-value: 3.5e-08
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S-----GGGGXX CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdldeLkn 44 
                 +L++L+  +N++t++++l++  +L+ +++  Nn+i+dl++L+n
  EFC38628.1 427 KLKELYAIGNNITSLGSLRNTCQLRGINM-CNNKIQDLSGLQN 468
                 8******************9999******.788*******986 PP

  == domain 3  score: 20.2 bits;  conditional E-value: 2.2e-07
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlitdl 39 
                 nL++L    Nq++d+  l ++ nL++Ld+  N  +++l
  EFC38628.1 471 NLQYLRVDINQISDLRVLDGFSNLQYLDCGYN-ELESL 507
                 99******88*******************556.77666 PP

  == domain 4  score: 12.4 bits;  conditional E-value: 6.3e-05
                 --EEE--SS---E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdiplleklpnLkeLdLsgNnlitdl 39 
                 Le L L +N++  +p++     Lk+L+L + n+i +l
  EFC38628.1 517 LEDLILYQNKIMQVPSFH-QVLLKSLYL-NTNQIVQL 551
                 899*************99.9********.55598766 PP

  == domain 5  score: 14.4 bits;  conditional E-value: 1.5e-05
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGGXX CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeLkn 44 
                 L++L+L+ Nq+  +p+  l   p L++L+L +Nn+i+ +++L+n
  EFC38628.1 538 LKSLYLNTNQIVQLPNqfLF-SPLLQYLNL-SNNKIEHISPLSN 579
                 99*****66*******9644.8********.666*******987 PP

  == domain 6  score: 15.3 bits;  conditional E-value: 7.9e-06
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                  L++++Ls N++++i+    l+ + n +e+ +++N +i
  EFC38628.1 582 MLRNVNLSFNNIQSIDEilhLKYCRNIEEVKINDN-PI 618
                 59***************854446*********777.55 PP

  == domain 7  score: -3.1 bits;  conditional E-value: 5
                 H.-TT--EEE CS
       LRR_4  21 k.lpnLkeLd 29 
                 + lpnL  Ld
  EFC38628.1 630 GiLPNLNNLD 639
                 5589998887 PP

  == domain 8  score: -2.2 bits;  conditional E-value: 2.5
                  S---E-S-HHH-TT--EE CS
       LRR_4   11 NqltdiplleklpnLkeL 28  
                  N ++d ++   +pnL+ L
  EFC38628.1 1006 NSISDSQNGT-NPNLEAL 1022
                  5677655544.8999866 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   2.5     7e-08   0.00018       6      61 .]     362     415 ..     358     415 .. 0.95
   2 !    9.5   2.9   0.00032      0.81       3      61 .]     428     482 ..     426     482 .. 0.84
   3 !    9.8   4.2   0.00025      0.65       1      61 []     470     527 ..     470     527 .. 0.84
   4 !   23.6   8.6   1.2e-08   3.2e-05       3      61 .]     538     593 ..     537     593 .. 0.94
   5 !    5.2   0.5     0.007        18       3      34 ..     583     615 ..     581     620 .. 0.72
   6 ?   -3.3   0.2       3.2   8.1e+03       7      30 ..     997    1022 ..     995    1026 .. 0.64

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 7e-08
                 EE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   6 LdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++++   ++s++  +F+ + nL+ L L  N l++l  g++ +L++L+ L L++NrL
  EFC38628.1 362 INIRGEEISSIKERVFEPFYNLRALFLDTNVLQSL--GTLKNLNQLECLSLNDNRL 415
                 6888899****************************..7****************98 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00032
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L++L+   N++tsl  ++ ++  +L+ +++ nN+++ ls   +++ ++L++L ++ N++
  EFC38628.1 428 LKELYAIGNNITSL--GSLRNTCQLRGINMCNNKIQDLS--GLQNNRNLQYLRVDINQI 482
                 66666666777777..46788889**************9..*************99987 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00025
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nL++L ++ N++++l+  +  g+snL++Ld ++N+l++l++    +L  L+ L L +N++
  EFC38628.1 470 RNLQYLRVDINQISDLR--VLDGFSNLQYLDCGYNELESLHNFLRYNL-LLEDLILYQNKI 527
                 699***********998..689999***************96555555.888888877775 PP

  == domain 4  score: 23.6 bits;  conditional E-value: 1.2e-08
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L+sL+L+ N++  l+ ++ ++ + L++L+LsnN+++++s   +s++  Lr  +Ls N++
  EFC38628.1 538 LKSLYLNTNQIVQLPNQFLFS-PLLQYLNLSNNKIEHIS--PLSNCIMLRNVNLSFNNI 593
                 99***************9995.****************9..7888889*********97 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.007
                 -SEEE-TTS--SEE-TTSSTT.-TT--EEE--S CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg.lsnLkvLdLsn 34 
                 L++++Ls+N+++s+d     + ++n ++ ++++
  EFC38628.1 583 LRNVNLSFNNIQSIDEILHLKyCRNIEEVKIND 615
                 8999*********99865444455555555555 PP

  == domain 6  score: -3.3 bits;  conditional E-value: 3.2
                  E-TTS-..-SEE-TTSSTT-TT--EE CS
       LRR_8    7 dLsnNr..ltslddeaFkglsnLkvL 30  
                   +s+N+   +s++d++  +++nL+ L
  EFC38628.1  997 RISSNSilKNSISDSQNGTNPNLEAL 1022
                  56677632246777777777888776 PP

>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   1.3      0.03        76       3      16 ..     811     824 ..     809     827 .. 0.79
   2 !   19.5   0.1   2.2e-07   0.00055       2      19 ..     836     853 ..     835     853 .. 0.94
   3 !   18.6   0.2   4.1e-07    0.0011       3      18 ..     868     883 ..     866     886 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.03
                 HHHHHHHHHHHHHH CS
          IQ   3 aaikIQaawRGyla 16 
                 ++++IQ+++R +++
  EFC38628.1 811 SVCLIQRWFRFWRV 824
                 7899******6665 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 2.2e-07
                 HHHHHHHHHHHHHHHHHH CS
          IQ   2 kaaikIQaawRGylaRkr 19 
                 +aa+kIQ++w+Gy  Rk+
  EFC38628.1 836 EAAVKIQKVWKGYISRKK 853
                 79**************96 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 4.1e-07
                 HHHHHHHHHHHHHHHH CS
          IQ   3 aaikIQaawRGylaRk 18 
                 aa+kIQ++w+Gy++R 
  EFC38628.1 868 AATKIQSVWKGYRVRT 883
                 9**************6 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   1.9   3.8e-06    0.0097      59     142 ..     349     431 ..     338     436 .. 0.80
   2 !    4.4   3.3    0.0092        24      27     131 ..     434     533 ..     425     541 .. 0.66
   3 !   21.9   4.6   3.8e-08   9.8e-05      48     155 ..     542     648 ..     537     654 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3.8e-06
       LRR_9  59 gfPllkrlktlllnnnr...ivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkql 142
                 ++P+ k  +t++l n r   i  i+e + e   nl++l l  n lq+l++   l +l++le+lsl +n +t+ +  r+ +  klk+l
  EFC38628.1 349 NMPFEKDDNTVVLINIRgeeISSIKERVFEPFYNLRALFLDTNVLQSLGT---LKNLNQLECLSLNDNRLTSIQMNRE-IASKLKEL 431
                 57777777776666655444999999***********************9...778899************9998887.56777766 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0092
       LRR_9  27 rgykipvienlGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                  g+ i+ +  l  t  q+  i++ +n+i++l g+   + l+ l ++ n+i  +   + +   nl+ l    nel++l ++        le l l +n +
  EFC38628.1 434 IGNNITSLGSLRNT-CQLRGINMCNNKIQDLSGLQNNRNLQYLRVDINQISDLR--VLDGFSNLQYLDCGYNELESLHNFLRY--NLLLEDLILYQNKI 527
                 55555555555544.4899999999******99999999999999999997553..444556777777777777777664333..23356666666666 PP

       LRR_9 126 tnkkey 131
                 ++ + +
  EFC38628.1 528 MQVPSF 533
                 665555 PP

  == domain 3  score: 21.9 bits;  conditional E-value: 3.8e-08
       LRR_9  48 dlsdndirkldg.fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrll 145
                  l+ n+i +l + f +   l+ l l+nn+i +i++ l++++  l+++ l+ n++q++ ++  l   +++e + + +np+++   yr+ +i  l++l  l
  EFC38628.1 542 YLNTNQIVQLPNqFLFSPLLQYLNLSNNKIEHISP-LSNCI-MLRNVNLSFNNIQSIDEILHLKYCRNIEEVKINDNPICKGVLYRELLIGILPNLNNL 638
                 58899***9976366777899************98.56655.699****************************************************99 PP

       LRR_9 146 dfrkvklker 155
                 d + v ++ r
  EFC38628.1 639 DGEPVSMNSR 648
                 9888877766 PP

>> Adeno_E3_CR2  Adenovirus E3 region protein CR2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   1.4   0.00015      0.38       6      36 ..    1250    1282 ..    1247    1284 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00015
  Adeno_E3_CR2    6 iaIivaVvvGla..iIiicmlyYaCcYrkhraq 36  
                    i+Iiv+VvvG++  i i+  l Y    +k  aq
    EFC38628.1 1250 IGIIVGVVVGVVggIAILAALFYLYVLKKQGAQ 1282
                    889999999987666666667776666666655 PP

>> Arch_flagellin  Archaebacterial flagellin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   6.1    0.0008       2.1      41     158 ..    1090    1230 ..    1082    1235 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0008
                      HHHHHHHHT--EEEEEEEEEE-SSSSSEEEEEEE--TTS--EEGGG-EEEEEESS--EE--E............................... CS
  Arch_flagellin   41 eesteqvssgleitgdvgdsatngtineitiyvklnaGsspidlnkttisvtddgqetlltad.......................efgivvi 110 
                       + t+q++s++++ ++   s+++g++ +i+ + k+  Gs+++ +++ +  +++ +   +++ d                       ++ +v++
      EFC38628.1 1090 VTHTAQIESDMDLRSISSRSTDSGKLRKINQVDKVMEGSTRVTMTNPSKKYLVYT--ISTSEDktveieikptnsdkqglftvtvtSSILVSV 1180
                      5789************************************999998888777777..223333446778*********999999988888999 PP

                      ..............T-EE-TT-EEEEEEE--TTT---TT-EEEEEEE-SSS- CS
  Arch_flagellin  111 sdtdgsltng....devlekgekvelevnvneddgitagdevsvevvpenGa 158 
                      sd++g++++     +++l+ ++ ++l +    + +  +g+++  e+ p++G 
      EFC38628.1 1181 SDENGGSKEValdqKQYLDTDKSMKLSIPI--KASTSNGKTIDFEINPPDGI 1230
                      99999888889999***************9..5999**************97 PP

>> SKG6  Transmembrane alpha-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   5.5   0.00085       2.2      12      33 ..    1252    1273 ..    1242    1275 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00085
        SKG6   12 IavaVaVPVaViiivLlailif 33  
                  I v+V+V+V+  i++L+a++++
  EFC38628.1 1252 IIVGVVVGVVGGIAILAALFYL 1273
                  559*****************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4150  (0.231469); expected 358.6 (0.02)
Passed bias filter:                      770  (0.0429472); expected 358.6 (0.02)
Passed Vit filter:                       378  (0.0210832); expected 17.9 (0.001)
Passed Fwd filter:                        60  (0.00334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.95u 0.44s 00:00:02.39 Elapsed: 00:00:00.67
# Mc/sec: 5953.10
//
Query:       EFC38629.1  [L=934]
Description: rhoGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.2e-20   72.0   4.5    7.2e-20   72.0   4.5    2.2  2  RhoGEF    RhoGEF domain
    1.9e-19   69.2  19.9      6e-10   38.7   1.7    3.7  4  LRR_8     Leucine rich repeat
    4.5e-10   39.6  19.2    0.00022   21.5   7.0    4.0  3  LRR_4     Leucine Rich repeats (2 copies)
  ------ inclusion threshold ------
      0.065   13.7   3.2        1.4    9.4   0.1    3.3  3  PH        PH domain
       0.26   12.0  18.9          2    9.3   0.2    6.5  7  LRR_1     Leucine Rich Repeat
        0.3   11.2  11.9        4.7    7.5   0.0    4.2  4  LRR_6     Leucine Rich repeat


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.4       3.9   1.2e+04     100     121 ..      84     105 ..      78     132 .. 0.53
   2 !   72.0   4.5   2.4e-23   7.2e-20       4     179 ..     497     684 ..     494     687 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3.9
                 HHHHHHHHHHHHHHHHHHHHHH CS
      RhoGEF 100 alkllkelskknkkfkafleea 121
                 alk +k+++k++kk + ++++ 
  EFC38629.1  84 ALKQYKTNKKEQKKQRMYINKN 105
                 5555555444444444444332 PP

  == domain 2  score: 72.0 bits;  conditional E-value: 2.4e-23
                 HHHHHHHHHHHHHHHHHHHTHCCCHHCT......CCHHHHHH........HHCTTHHHHH.HHHHHHHHHHHHHHH......HHHTTSS-S-SHHHHHH CS
      RhoGEF   4 ElleTErsYvrdLkvlvevylkplsele......vlseeeik........iiFsnieeil.elhrsflleeLeerl.....keseeqkeaqsigdvflk 82 
                  ll++E +Y+++++v  ++  +pl +        ++s++e++         i +n + ++ +         L+++l      +s ++++  +i++vf++
  EFC38629.1 497 QLLNSETEYISHMNVFNDILFEPLLDICknrnefNISNSERDcvlpsvilDIIGNARGLYiD---------LKSKLlpltqARSMKNEDSIEISKVFET 586
                 699**************999988776667788997777777732222222455555555534.........444444433224556666789******* PP

                 HHSTHHH.HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHTSGGGTT--HHHHTTHHHHHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHH CS
      RhoGEF  83 fadkfkk.YseYcsnypnalkllkelskknkkfkafleeaeerpecskldLeslLikPvqRlprYpLLLkellkntpeshpdyealkkaleaikevas 179
                  +++f++ Y++Y s y+na ++l++l+k+n++f ++++ +++ p cs+   + +L+ Pv Rl  Y  +L+++l++tp+shpd+++l+ ++ +++ +++
  EFC38629.1 587 RLEEFRQlYVKYPSVYENAAAVLNKLRKTNEEFDKYIKLRKRLPICSGHIYDAYLLLPVTRLFIYLKFLQKILRYTPDSHPDFKNLRIVVRELRHIVQ 684
                 ******99***********************************************************************************9999986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.1   1.4e-07   0.00041       9      61 .]     280     332 ..     273     332 .. 0.77
   2 !   38.7   1.7     2e-13     6e-10       2      61 .]     297     355 ..     296     355 .. 0.96
   3 !   35.1   2.2   2.7e-12     8e-09       2      61 .]     321     378 ..     320     378 .. 0.96
   4 !   11.9   0.1   4.8e-05      0.14      26      61 .]     391     425 ..     385     425 .. 0.89

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1.4e-07
                 TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGT.T--S-.EEE--SS-- CS
       LRR_8   9 snNrltslddeaFkglsnLkvLdLsnNllttlspgafs.gLpsLrsLdLsgNrL 61 
                 + N l+ ++ ++     n + Ld+snN ++++ p +f+  L+sL++L L +N L
  EFC38629.1 280 RYNILSQVPIQSLVEGGNITLLDISNNYISSI-PTWFAtTLKSLTYLFLPYNYL 332
                 56777888888888888888899999999999.788863589999999888876 PP

  == domain 2  score: 38.7 bits;  conditional E-value: 2e-13
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 n t Ld+snN+++s++  + ++l++L++L L +N l  l p+ f  +++L++LdLs+N++
  EFC38629.1 297 NITLLDISNNYISSIPTWFATTLKSLTYLFLPYNYLYEL-PENFCEMKKLKELDLSNNNF 355
                 6788************999999*****************.9*****************85 PP

  == domain 3  score: 35.1 bits;  conditional E-value: 2.7e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L L  N+l +l+  + + +++Lk+LdLsnN+ + + pg++  Lp++  LdLsgN L
  EFC38629.1 321 SLTYLFLPYNYLYELPENFCE-MKKLKELDLSNNNFEYV-PGCILKLPNILTLDLSGNSL 378
                 79*************999999.*****************.9*****************87 PP

  == domain 4  score: 11.9 bits;  conditional E-value: 4.8e-05
                 T--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  26 nLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  L+ L++s N+l+ + p+ +++L++L++   ++N+L
  EFC38629.1 391 TLTDLNISGNELREV-PDDIRQLKKLKYFKYNDNDL 425
                 5999***********.9*********9988888876 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.5   5.1e-06     0.015       2      36 ..     297     332 ..     297     338 .. 0.81
   2 !   21.5   7.0   7.3e-08   0.00022       1      40 [.     343     386 ..     343     390 .. 0.81
   3 !    8.8   0.2   0.00073       2.2       3      28 ..     392     418 ..     391     426 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 5.1e-06
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 n + Ld+snN +++ip  ++  l++L++L L   n++
  EFC38629.1 297 NITLLDISNNYISSIPTwFATtLKSLTYLFL-PYNYL 332
                 6788**************8866********9.33355 PP

  == domain 2  score: 21.5 bits;  conditional E-value: 7.3e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---...--GG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli...tdld 40 
                 ++L++LdLsnN+   +p+  l klpn  +LdLsgN+l+   +d++
  EFC38629.1 343 KKLKELDLSNNNFEYVPGciL-KLPNILTLDLSGNSLLifpNDIS 386
                 69****************633.6************6664446665 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00073
                 --EEE--SS---E-S-.HHH-TT--EE CS
       LRR_4   3 LevLdLsnNqltdipl.leklpnLkeL 28 
                 L+ L++s+N l+++p  +++l++Lk++
  EFC38629.1 392 LTDLNISGNELREVPDdIRQLKKLKYF 418
                 899*************8889****986 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       2.1   6.2e+03      34      60 ..      89     114 ..      68     131 .. 0.70
   2 ?    3.2   0.0     0.042   1.3e+02       4      37 ..     398     443 ..     395     502 .. 0.74
   3 ?    9.4   0.1   0.00047       1.4      59     104 ..     850     900 ..     831     901 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.1
                 SSTTCTTESSEEEEEESTTEEEEEEEC CS
          PH  34 kndksekdkepkgsislsncevvevva 60 
                 k   ++++k+ ++ i+ ++ +++++++
  EFC38629.1  89 KTN-KKEQKKQRMYINKNKYDITDTKE 114
                 334.56677777777777777777655 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.042
                 EEEEEEETSSSSCSEEE.EEEEEETTEEEEESST...........T CS
          PH   4 eGwLlkkgsgkkkswkk.rwfvLkdsellyyknd...........k 37 
                 +G+ l+  +++  + kk ++f  +d++l+yy  +            
  EFC38629.1 398 SGNELREVPDDIRQLKKlKYFKYNDNDLFYYTTSlilsklnteedL 443
                 555344444433388888**************99776644333331 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00047
                 EC.....TTSSSSTSEEEEEESTSSSTEEEEEEESSHHHHHHHHHHHHHHH CS
          PH  59 va.....tedpkrkfcfelriverngsrtyllqasseeerkeWikaiqsai 104
                 ++     +++ k + +f l+i++ ++   + + ++++ee+ +W k i++a+
  EFC38629.1 850 EKekwsiNDKYKGERQFTLIINTPSKRIPLGFICETKEECLDWFKEIEKAL 900
                 33567765677777788887775566699*******************997 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0         3   8.9e+03       6      20 ..     278     292 ..     275     293 .. 0.84
   2 ?    3.5   0.0     0.052   1.6e+02       1      16 [.     297     312 ..     297     319 .. 0.77
   3 ?   -2.9   0.1         6   1.8e+04       1      18 [.     321     337 ..     321     341 .. 0.68
   4 ?    9.3   0.2   0.00066         2       1      20 [.     344     362 ..     344     366 .. 0.74
   5 ?    4.6   1.1     0.023        69       4      20 ..     370     385 ..     367     392 .. 0.71
   6 ?    2.9   0.0     0.081   2.4e+02       2      20 ..     392     409 ..     391     415 .. 0.78
   7 ?   -2.4   0.3       4.7   1.4e+04       5      18 ..     521     534 ..     520     543 .. 0.65

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 3
       LRR_1   6 dLsnnpllglppnsf 20 
                 + ++n+l++ p++s+
  EFC38629.1 278 YFRYNILSQVPIQSL 292
                 6799****9999886 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.052
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 n + Ld+snn ++++p
  EFC38629.1 297 NITLLDISNNYISSIP 312
                 5678*******96554 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 6
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L L +n l   +p+
  EFC38629.1 321 SLTYLFLPYNYL-YELPE 337
                 599999999998.34444 PP

  == domain 4  score: 9.3 bits;  conditional E-value: 0.00066
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++LdLsnn++    p ++
  EFC38629.1 344 KLKELDLSNNNF-EYVPGCI 362
                 7**********9.3444444 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.023
       LRR_1   4 hLdLsnnpllglppnsf 20 
                 +LdLs+n+ll + pn++
  EFC38629.1 370 TLDLSGNSLL-IFPNDI 385
                 8********4.555554 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.081
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ L++s+n l +  p+++
  EFC38629.1 392 LTDLNISGNEL-REVPDDI 409
                 888*******9.6666655 PP

  == domain 7  score: -2.4 bits;  conditional E-value: 4.7
       LRR_1   5 LdLsnnpllglppn 18 
                 Ld++ n+++  ++n
  EFC38629.1 521 LDICKNRNEFNISN 534
                 78877777444444 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.2       2.6   7.7e+03       5      13 ..     298     306 ..     297     309 .. 0.76
   2 ?    7.5   0.0    0.0016       4.7       4      15 ..     344     355 ..     341     358 .. 0.88
   3 ?    3.3   0.2     0.035     1e+02       3      14 ..     366     377 ..     364     378 .. 0.84
   4 ?    6.1   0.5    0.0044        13       3      15 ..     390     402 ..     388     403 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.6
       LRR_6   5 LteLdLsgN 13 
                 +t Ld+s N
  EFC38629.1 298 ITLLDISNN 306
                 5679**999 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0016
       LRR_6   4 hLteLdLsgNdI 15 
                 +L+eLdLs N++
  EFC38629.1 344 KLKELDLSNNNF 355
                 8*********97 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.035
       LRR_6   3 thLteLdLsgNd 14 
                 +++ +LdLsgN 
  EFC38629.1 366 PNILTLDLSGNS 377
                 6889*******6 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0044
       LRR_6   3 thLteLdLsgNdI 15 
                 ++Lt L++sgN++
  EFC38629.1 390 NTLTDLNISGNEL 402
                 79*********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (934 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1400  (0.0780858); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.78u 0.36s 00:00:01.14 Elapsed: 00:00:00.54
# Mc/sec: 5242.43
//
Query:       EFC38630.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.4e-11   42.8   0.4    6.4e-11   42.8   0.4    3.6  3  OTU             OTU-like cysteine protease
    1.5e-06   27.9   8.5      9e-05   22.0   0.1    3.2  3  Peptidase_C65   Peptidase C65 Otubain
  ------ inclusion threshold ------
       0.94    7.5   9.8        1.3    7.0   9.8    1.1  1  Sporozoite_P67  Sporozoite P67 surface antigen
        2.9    6.9   8.0        0.3   10.1   2.5    2.0  2  FUSC-like       FUSC-like inner membrane protein yccS


Domain annotation for each model (and alignments):
>> OTU  OTU-like cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   1.3     0.062   2.8e+02      21      65 ..       9      56 ..       1      69 [. 0.72
   2 ?   -0.4   0.4      0.34   1.5e+03      12      43 ..      79     113 ..      75     143 .. 0.62
   3 !   42.8   0.4   1.4e-14   6.4e-11       2     127 .]     153     307 ..     152     307 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.062
                HCCHHHHHHHHHCHHHHHH...TSSHHCCHHHHCCHHHHHHHTTSTTH CS
         OTU 21 elrkakvseLreklaeylr...ehseelelfleeeeegylkeiektaa 65
                 l +++ ++L e+ a++++   +    ++  +e+++++ lke+e+ ++
  EFC38630.1  9 ALHEQELQNLAEEKAKEFEkiaNSGAATKKKFENKWKEKLKEVEQRHE 56
                456667788888888777766666666777777777777999999985 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.34
                 HHCCCSS.S.HCCHHHHHHHHHCH..HHHHHTSSH CS
         OTU  12 sqqlwgvsd.elrkakvseLrekl..aeylrehse 43 
                  +q++ + + e++ka++++L+++   +++++++ +
  EFC38630.1  79 PKQTISKDGeEKKKAEQRKLKNAKkkQKKVQKQTD 113
                 56666444466777777888887733333443333 PP

  == domain 3  score: 42.8 bits;  conditional E-value: 1.4e-14
                 -SS-HHHHHHHHCCCSS.S.....HCCHHHHHHHHHCHHHHHH.......................TSSHHCCHHHHCCHHH...HHHHTTSTTHHHHH CS
         OTU   2 gDGnCLlravsqqlwgvsd.....elrkakvseLreklaeylr.......................ehseelelfleeeeeg...ylkeiektaawgge 69 
                 +DG+CL+r+ ++ql  + +     +l +   seL ek +++l+                        +s+e+ +f+ +  e+   y + +e+ ++wgg+
  EFC38630.1 153 SDGHCLYRSLADQLNTNLNnsftkQLLERANSELSEKNKRELKslttsnglftylhlrslianqlrRKSDEYFPFVMDVCETmdeYANIVESSSEWGGQ 251
                 8*************98777888874555556677777777777777777777888888888888878888888888877666788************** PP

                 HHHHHHHHHCTS-EEE.ETTSSSSEEEE-TT-EEE--TTS-GGGS-SS-EEEEEETTEE CS
         OTU  70 leifalahiLrrpIiV.lksesgeelvglkfegvylplekdkslclkypihlyylgeHy 127
                 +ei+a  ++  ++ i+ + ++sg  l+g +      p    + l+++y++  y+lgeHy
  EFC38630.1 252 VEIQAFLDLCGKQFILkIVQDSGIVLMGDNS---MTPHPSSSILFVSYHKRYYALGEHY 307
                 **********999999777888888888444...4699********************9 PP

>> Peptidase_C65  Peptidase C65 Otubain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.4      0.17   7.4e+02      75     118 ..      17      58 ..       3      79 .. 0.48
   2 !    9.7   0.1   0.00011      0.51      26      57 ..     132     163 ..      98     173 .. 0.84
   3 !   22.0   0.1     2e-08     9e-05     104     195 ..     175     262 ..     164     290 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.17
                    HHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHHTTSS-H CS
  Peptidase_C65  75 rikerveklkealeslgfdeevvedfleaflellkkiekktees 118
                    ++ e+ +k  e+++       + ++f ++ +e lk++e+  e++
     EFC38630.1  17 NLAEEKAKEFEKIA--NSGAATKKKFENKWKEKLKEVEQRHETE 58 
                    33333333333333..2222333444455555555555444444 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00011
                    HHHHHHHHHHHTTEEEEE-B--SSTHHHHHHH CS
  Peptidase_C65  26 aailkkikllsekYssiRrvrgDGnCfyRafl 57 
                    ++  ++ik+  e  +si +++ DG+C+yR+++
     EFC38630.1 132 DVEIERIKQYLEPNQSIFEIDSDGHCLYRSLA 163
                    556677888888889999************86 PP

  == domain 3  score: 22.0 bits;  conditional E-value: 2e-08
                    HHHHHHHHHTTSS-HH....HHHHHHTSHHHHHHHHHHHHHHHHHHHHHTHHHHGGGS-TT.--HHHHHHHHTSSTT--B-HHHHHHHHHHTT CS
  Peptidase_C65 104 flellkkiekkteeseekaeellkafneqeesdyivvflRlltsaelkthadeyepFldel.stveeFceqevepvnkEaDnvqitaLaealg 195
                    +++ll++ +++ +e++   +  lk +++++   +   +lR l+ ++l++++dey pF+++  +t++e+  + ve+ ++   +v+i+a+ +  g
     EFC38630.1 175 TKQLLERANSELSEKN---KRELKSLTTSNG-LFTYLHLRSLIANQLRRKSDEYFPFVMDVcETMDEYA-NIVESSSEWGGQVEIQAFLDLCG 262
                    4566666665555554...466777777776.56778899********************99******6.568***************99874 PP

>> Sporozoite_P67  Sporozoite P67 surface antigen
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   9.8   0.00029       1.3      96     180 ..      50     134 ..      29     140 .. 0.73

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00029
  Sporozoite_P67  96 eselqsdteineddkGskedseedddeeeeednkstsskdgkgskka.qpgvssssgsttsqtdlstklsqtglg..asGshaqqdpa 180
                     e+e +++te+ e +  s  d+eed   e+e   k t skdg + kka q  ++++  +    ++++ + +q+      sG  +q+d  
      EFC38630.1  50 EVEQRHETELWEAKMSSTVDDEED---EKESTPKQTISKDGEEKKKAeQRKLKNAKKKQKKVQKQTDARQQAHQEfmDSGGVTQRDVE 134
                     445555666666655555554443...4577889*************99999999988888888877777765444488888888865 PP

>> FUSC-like  FUSC-like inner membrane protein yccS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.3      0.13   5.8e+02     212     269 ..      16      50 ..       8      70 .. 0.54
   2 ?   10.1   2.5   6.8e-05       0.3     127     222 ..      89     186 ..      86     215 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.13
   FUSC-like 212 qrllelqakaceeiaqaillnkpyqhserleraleeleqslellakqnnekekellaa 269
                 q+l+e  ak+ e+ia+                       s + ++k+ ++k+ke l++
  EFC38630.1  16 QNLAEEKAKEFEKIAN-----------------------SGAATKKKFENKWKEKLKE 50 
                 4445555555555554.......................4444444444444444433 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 6.8e-05
   FUSC-like 127 reddleakrlaLaqqnakvvealnaareillsrlk..skrgqpetksrrllrlyfvaqDihErassshydYeelreafknsdvlfrfqrllelqakac 222
                 ++++ e+++l+ a++ +k v++++ ar++ ++++   ++ +q++ + +r+ ++    q i E  s  h  Y +l+++++ +    + ++lle+  +++
  EFC38630.1  89 EKKKAEQRKLKNAKKKQKKVQKQTDARQQAHQEFMdsGGVTQRDVEIERIKQYLEPNQSIFEIDSDGHCLYRSLADQLNTNLNNSFTKQLLERANSEL 186
                 567889999999******************99998777889999999999999999***********************9999999999988876665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3674  (0.204919); expected 358.6 (0.02)
Passed bias filter:                      760  (0.0423894); expected 358.6 (0.02)
Passed Vit filter:                       138  (0.00769703); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.88u 0.38s 00:00:01.26 Elapsed: 00:00:00.54
# Mc/sec: 1742.05
//
Query:       EFC38631.1  [L=955]
Description: structural maintenance of chromosome 2 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.8e-62  210.0  29.6      3e-61  206.7  29.6    3.0  1  SMC_N           RecF/RecN/SMC N terminal domain
    1.1e-18   67.6   2.0    1.4e-18   67.3   0.4    2.0  2  SMC_hinge       SMC proteins Flexible Hinge Domain
    2.1e-16   60.6  15.2    2.1e-16   60.6  15.2    3.2  3  AAA_15          AAA ATPase domain
    3.8e-15   56.5   6.2    4.3e-08   33.3   0.0    3.4  3  AAA_21          AAA domain, putative AbiEii toxin, Type IV TA
    1.1e-11   45.6  28.8    1.1e-11   45.6  28.8    5.5  4  AAA_23          AAA domain
    2.7e-05   23.8   0.1    7.8e-05   22.3   0.1    1.7  1  AAA_29          P-loop containing region of AAA domain
     0.0059   17.1   0.1       0.14   12.7   0.0    5.5  4  ABC_tran        ABC transporter
  ------ inclusion threshold ------
       0.13   12.5   0.3        0.7   10.2   0.1    2.4  2  MHB             Haemophore, haem-binding
       0.93    9.3   5.9         18    5.1   1.6    3.1  2  SNCAIP_SNCA_bd  Synphilin-1 alpha-Synuclein-binding domain


Domain annotation for each model (and alignments):
>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  206.7  29.6   1.5e-64     3e-61       1     215 [.       2     904 ..       2     908 .. 0.99

  Alignments for each domain:
  == domain 1  score: 206.7 bits;  conditional E-value: 1.5e-64
                 EEEEEEEESETTEECEEEEEETTSSEEEEEESTTSSHHHHHHHHHHHCTT.TTTTTTCHCCCCCC--BTTCSSTTEEEEEEEEEETTEE....SSSSSS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxx RF
       SMC_N   1 vlkrleienFksyagktvilpfsksftaivGpNGSGKsnlldAilFvLGersakklrseklsdlihkskekasvkkaeveitfdnedkk....lkieke 95 
                 ++k++ i++Fksya +tv   f+ksf+ai+G NGSGKsn+ldAi+FvLG ++ +++r+++l++li+k + +a ++ka+v+++fdn+d++      ++++
  EFC38631.1   2 YIKEVYIDGFKSYASRTVLNGFDKSFNAITGLNGSGKSNILDAICFVLGISNLSQVRANNLTELIYK-QGQAGITKASVSVVFDNSDSAnspvGYEDQS 99 
                 79****************************************************************9.9******************998887788999 PP

                 CEEEEEEEETTSEEEEEETTEEE-HHHHHHHHHCTT-STT........................................................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........................................................... RF
       SMC_N  96 evsisrrvkrkgeseykingkevtkkevsellesagiske........................................................... 135
                  ++++r+++ +g+++y+ing++++ + v++l++s++++ +                                                           
  EFC38631.1 100 TITVQRQIMIGGKNKYMINGRNAQLNRVQNLFHSVQLNVNnphflimqgritkvlnmkpieilgmieeasgtrmfelkkssaqktiikkdkkleeieri 198
                 9************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC38631.1 199 lseeitpkleklkserakclqhetalvqlknleryytayeyyshknqlkklekeektlkdkiegvreqiekyiteedeiqkkidsmknqkqnrmkqdln 297
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC38631.1 298 tlhnslssinkdlskrkpeleskikelnreneklnelekqleeetasrevlskkhaeakikseelkkkmedctnrmenlkkqqeavsagiavnvndgng 396
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC38631.1 397 ktlteqimdcekqitslkvkinqntvtltylkkgleektsllktqsnedtnikqhlqqlnesleeikkkledlnfneiiykqteeeieqietkiqekkn 495
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC38631.1 496 eivklkselshiyidynkkhisgevmgiianlfrakekkhicalevcasaklgqlvvdnqqtakdvikkgdlnrrvttvplntisysrkfekseilala 594
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC38631.1 595 ekrgaqlalnlisydkkvenamkycfgntlvaenmetakqvafdqhilaktvtwdgdvfepagtltgethssemkklltankwikkeeesfneegsefh 693
                 *************************************************************************************************** PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC38631.1 694 fskdketlpackqrlaemkescenlsktinkkamalyektedeytelvkkkdiveadkkkigevieeldekkkktiedtwkkvdeyfrsifsmllvgas 792
                 *************************************************************************************************** PP

                 ................................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHC CS
                 ................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 ................................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreeml 202
                                                 +LSgG+++L+al+L++++ ++kpap+y+lDeidaaLD ++++++ ++lk++ +n+Qfiv+sl+e+m+
  EFC38631.1 793 akleppsdavngpldglevkvafngawkesltELSGGQRSLLALSLILSLLRFKPAPVYILDEIDAALDPSHTQNIGRMLKQHFTNSQFIVVSLKEGMF 891
                 *************************************************************************************************** PP

                 CC-SCEEEEEEEE CS
                 xxxxxxxxxxxxx RF
       SMC_N 203 ekadklvgvtkve 215
                 ++a+ l+++++v+
  EFC38631.1 892 QNANVLFKTKFVN 904
                 *******999854 PP

>> SMC_hinge  SMC proteins Flexible Hinge Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.3   0.4   6.9e-22   1.4e-18       4     117 .]     520     636 ..     517     636 .. 0.92
   2 ?   -3.6   0.1       6.8   1.3e+04      78      99 ..     736     760 ..     719     761 .. 0.65

  Alignments for each domain:
  == domain 1  score: 67.3 bits;  conditional E-value: 6.9e-22
   SMC_hinge   4 vlGrladlievd.egyekAveaalgnrlqalvvedeetakkiieflkkknagratflpldrikqknkadgandkns....gavplidlvevddelrkal 97 
                 v+G +a+l++ + ++   A+e+ + ++l  lvv++++tak  i+    +   r+t +pl++i+ ++k+++ +        ga+ +++l+++d+++++a+
  EFC38631.1 520 VMGIIANLFRAKeKKHICALEVCASAKLGQLVVDNQQTAKDVIKKGDLN--RRVTTVPLNTISYSRKFEKSEILALaekrGAQLALNLISYDKKVENAM 616
                 89**********88888***********************999777777..89***********988888765544999******************** PP

   SMC_hinge  98 ryllgdtlvvdsldeAeela 117
                 +y +g+tlv++++++A+++a
  EFC38631.1 617 KYCFGNTLVAENMETAKQVA 636
                 *****************985 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 6.8
   SMC_hinge  78 s..gavplidlvevdde.lrkalry 99 
                 +    v+  d+ve d++ + +++++
  EFC38631.1 736 EytELVKKKDIVEADKKkIGEVIEE 760
                 3446666778899998888888876 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.6  15.2   1.1e-19   2.1e-16       1     267 [.       1     365 [.       1     383 [. 0.77
   2 ?   -3.7  26.0       3.8   7.6e+03     151     261 ..     351     502 ..     343     523 .. 0.58
   3 !   11.6   8.4   8.1e-05      0.16     164     360 ..     669     882 ..     520     885 .. 0.65

  Alignments for each domain:
  == domain 1  score: 60.6 bits;  conditional E-value: 1.1e-19
      AAA_15   1 MkIkkikikNFRslkd.veid.lseeltvliGkNnsGKSsilealdlFlnnkekkn.........................kkvikiekedleifenis 72 
                 M+Ik++ i  F+s+ + + ++ ++++++ + G N+sGKS+il+a+ + l  +   n                         ++v+++++++ +    ++
  EFC38631.1   1 MYIKEVYIDGFKSYASrTVLNgFDKSFNAITGLNGSGKSNILDAICFVLGIS---NlsqvrannlteliykqgqagitkasVSVVFDNSDSANSPVGYE 96 
                 ***************97666569999*******************9999988...334788999****************9888888888888888888 PP

      AAA_15  73 eskdikIdvef....................................................................aek.ekakeyektlkskekk 102
                    +i ++ +                                                                       k ++a++ +  +++k ++
  EFC38631.1  97 DQSTITVQRQImiggknkymingrnaqlnrvqnlfhsvqlnvnnphflimqgritkvlnmkpieilgmieeasgtrmfeL-KkSSAQKTIIKKDKKLEE 194
                 88888888888999999999999999999999999999999999************************987777775531.245566666666666666 PP

      AAA_15 103 kadlllkkkesdlkktikdkklklkknelsdekisvekkkskkelpkekeeklekekeelkidkedlkklikkleeslkkeeelknvlksaiiklllis 201
                  + +l +++  +l k++ ++   l+++   ++ +++e    ++e ++  ++ l+k ++e k+ k++++ + +++e+++++e+e++          + i 
  EFC38631.1 195 IERILSEEITPKLEKLKSERAKCLQHETALVQLKNLERYYTAYEYYSH-KNQLKKLEKEEKTLKDKIEGVREQIEKYITEEDEIQ----------KKID 282
                 666667777777777777776666666666666666666556666655.445555666667889999***********9999333..........3466 PP

      AAA_15 202 akRnvsdedsekkssllgklkekileealqekl.eeelteklkeiqeklkeidkklaeelk................kilkkk 267
                 + +n ++++ ++  ++l + +++i+++ ++ k   e+++++l++ +ekl+e++k+l+ee++                ++lkkk
  EFC38631.1 283 SMKNQKQNRMKQDLNTLHNSLSSINKDLSKRKPeLESKIKELNRENEKLNELEKQLEEETAsrevlskkhaeakiksEELKKK 365
                 77777888888888888888888888855544477788999***************999998866666444444443333333 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 3.8
      AAA_15 151 keeklekekeelkidkedlkklikkleeslkkee............................................elknvlksaiiklllisakRn 205
                 k+ +++ ++eelk++ ed+++  +   + +k++e                                             lk+ l+++  +l++ s++ +
  EFC38631.1 351 KHAEAKIKSEELKKKMEDCTNRME---NLKKQQEavsagiavnvndgngktlteqimdcekqitslkvkinqntvtltYLKKGLEEKTSLLKTQSNEDT 446
                 333333333333333333333333...333333355566666666666665555555555555555555555555555677888888888888888888 PP

      AAA_15 206 vsdedsekkssllgklkekileealqekleeelteklkeiqeklkeidkklaeelk 261
                 + ++  ++ +++l+++k+k+ + + +e   ++++e++++i++k++e+++++ + ++
  EFC38631.1 447 NIKQHLQQLNESLEEIKKKLEDLNFNEIIYKQTEEEIEQIETKIQEKKNEIVKLKS 502
                 88888888888888888888777766666888888888888888888887733222 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 8.1e-05
      AAA_15 164 idkedlkklikkleeslkkee...elknvlksaiiklllisakRnvsdedsekkssllgklkekileealqekleeelteklkeiqeklkeidkklaee 259
                 ++  +++k ikk ees+++e     +++  + +  + +   + +++ +++s+ +++  ++l+ek+ +e+ +     +++++ +  ++k+ e +++l+e+
  EFC38631.1 669 KKLLTANKWIKKEEESFNEEGsefHFSKDKETLPACKQRLAEMKESCENLSKTINKKAMALYEKTEDEYTE---LVKKKDIVEADKKKIGEVIEELDEK 764
                 23467788888899999988888999999999999999999999999999999999999999999888543...5556666667777788888888888 PP

      AAA_15 260 lkkilkkkidkikkfnykgkkneeieik................................ddeelplnknGsGvqrllllillileaekkdekeeknvi 326
                 +kk++++ ++k+        ++ ++ i+                                   + +l++ + G+++ll l+l +  ++ k     +  +
  EFC38631.1 765 KKKTIEDTWKKV--------DEYFRSIFsmllvgasakleppsdavngpldglevkvafnGAWKESLTELSGGQRSLLALSLILSLLRFK-----PAPV 850
                 888888888885........5555555577777777888888888899999999998888777778889999999999999999999999.....9999 PP

      AAA_15 327 lliEEPEahLHpqaqkvlikllkelandnktQvi 360
                 ++++E++a L p++ + + + lk    ++  Q i
  EFC38631.1 851 YILDEIDAALDPSHTQNIGRMLKQHFTNS--QFI 882
                 99999999998888877776666655555..555 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.4   1.4e-08   2.8e-05       1      26 [.      27      56 ..      27      99 .. 0.76
   2 ?    0.1   0.3      0.29   5.7e+02     175     238 ..     236     304 ..     181     375 .. 0.77
   3 !   33.3   0.0   2.2e-11   4.3e-08     220     296 ..     809     885 ..     668     885 .. 0.72

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.4e-08
      AAA_21  1 lnvliGpNgsGKSnLLdaldllarl....d 26
                +n+++G NgsGKSn+Lda+ ++ ++    +
  EFC38631.1 27 FNAITGLNGSGKSNILDAICFVLGIsnlsQ 56
                8******************88877665331 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.29
      AAA_21 175 yfgfakekrllqrlvrslklveielsdlgegeeliasvderlrer.....gvvflengdgqelparelS 238
                  + ++++k++l++l+++ k+  ++++  +e++e++ ++ + ++ +     ++ ++ ++++ ++  ++lS
  EFC38631.1 236 AYEYYSHKNQLKKLEKEEKTLKDKIEGVREQIEKYITEEDEIQKKidsmkNQKQNRMKQDLNTLHNSLS 304
                 456677777777777777777777777777777777777776666666665555555555555444444 PP

  == domain 3  score: 33.3 bits;  conditional E-value: 2.2e-11
      AAA_21 220 gvvflengdgqelparelSdGtkrll..alltallralkkgsllliDEpEngLHPkllrrllellkelsrngaQviltT 296
                   v +  ++  + +++elS G+++ll   l+++llr  +  +++++DE+++ L+P+ +  + ++lk++ + ++Q+i+++
  EFC38631.1 809 LEVKVAFNGAWKESLTELSGGQRSLLalSLILSLLRFKPA-PVYILDEIDAALDPSHTQNIGRMLKQHFT-NSQFIVVS 885
                 44444455555667899********878999999999999.************************77766.7****986 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.6  28.8   5.6e-15   1.1e-11       2     199 ..       6     310 ..       5     318 .. 0.69
   2 ?   -1.0  23.7       1.1   2.1e+03     116     195 ..     291     376 ..     288     384 .. 0.72
   3 ?   -2.3  27.0       2.7   5.5e+03      76     194 ..     388     506 ..     374     512 .. 0.51
   4 ?   -4.8  15.8         9   1.8e+04      99     197 ..     679     778 ..     549     781 .. 0.68

  Alignments for each domain:
  == domain 1  score: 45.6 bits;  conditional E-value: 5.6e-15
      AAA_23   2 Lkienfrsfrdqe.i.dFskgltlItGpNGaGKTTildAiklaLygetprlsrksgrgfeksdveiesegkvkayveltfenkdgry............ 86 
                 + i +f+s+   + +  F+k +++ItG NG+GK+ ildAi+++L+   ++ls  + +++ +  ++ ++ g +ka+v++ f n d  +            
  EFC38631.1   6 VYIDGFKSYASRTvLnGFDKSFNAITGLNGSGKSNILDAICFVLGI--SNLSQVRANNLTELIYKQGQAGITKASVSVVFDNSDSANspvgyedqstit 102
                 689******655525689**************************97..456665555555555555555667777888887777777778888877777 PP

      AAA_23  87 ..............................................................trsiererelskkkgkttkkaklelleideleqfise 123
                                                                                    +e + ++  + +++ a++ ++++d++ ++i++
  EFC38631.1 103 vqrqimiggknkymingrnaqlnrvqnlfhsvqlnvnnphflimqgritkvlnmkpieilgmI----EEASGTRMFELKKSSAQKTIIKKDKKLEEIER 197
                 8888888888899999999*********************************99999965551....44444444444555555555555444444443 PP

      AAA_23 124 ....llgskki..ilnlilflgqer.........................feefelkdkkerleelekeleeledekkllekl......eqekekekel 185
                     +++ k +   +++  +l+ e                          + e+e+k+ k+++e +++++e+  +e+++++k+      ++++  ++ l
  EFC38631.1 198 ilseEITPKLEklKSERAKCLQHETalvqlknleryytayeyyshknqlkKLEKEEKTLKDKIEGVREQIEKYITEEDEIQKKidsmknQKQNRMKQDL 296
                 111133333333323444444444455555555557777777776666655555568888899999999999999999999997777643344455577 PP

      AAA_23 186 eeleeeleeilkel 199
                 ++l + l +i+k+l
  EFC38631.1 297 NTLHNSLSSINKDL 310
                 77777777777766 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.1
      AAA_23 116 eleqfisellgskkiil.nlilflgqerfeefelkdkkerleelekeleeledekkllekl.....eqekekekeleeleeeleei 195
                   +q +++l +s  +i+ +l+  +++ + + +el++++e+l+elek+lee+++ ++ l k+     ++ +e +k+ e+  +++e++
  EFC38631.1 291 RMKQDLNTLHNSLSSINkDLSKRKPELESKIKELNRENEKLNELEKQLEEETASREVLSKKhaeakIKSEELKKKMEDCTNRMENL 376
                 5678889888888777757778899999999999**************************97555533333444333333333333 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 2.7
      AAA_23  76 eltfenkdgrytrsier...erelskkkgkttkkaklellei..deleqfisellgskkiilnlilflgqerfeefelkdkkerleelekeleeledek 169
                  +++++ +g+   ++++   ++e++ ++ k + ++++  l+   + le+++s l +++++  n+ + l+q ++   +l++ k++le+l+      ++++
  EFC38631.1 388 AVNVNDGNGK---TLTEqimDCEKQITSLKVKINQNTVTLTYlkKGLEEKTSLLKTQSNEDTNIKQHLQQLNE---SLEEIKKKLEDLNFNEIIYKQTE 480
                 4445555553...233311133333332222222222222223455666666555566666666666666665...66667777777766655555555 PP

      AAA_23 170 kllekle.qekekekeleeleeelee 194
                 +++e+ e +++ek++e+ +l++el  
  EFC38631.1 481 EEIEQIEtKIQEKKNEIVKLKSELSH 506
                 55555533667777778787777765 PP

  == domain 4  score: -4.8 bits;  conditional E-value: 9
      AAA_23  99 kkgkttkkaklelleideleqfisellgskkiilnlilflgqer............feefelkdkkerleelekeleeledekkllekleqekekekel 185
                 kk+++  +++++++  ++ +++++   ++  +           +            +++ + ++++++  el k+++  e++kk++ ++++e+  ek+ 
  EFC38631.1 679 KKEEESFNEEGSEFHFSKDKETLPACKQRLAEM----------KescenlsktinkKAMALYEKTEDEYTELVKKKDIVEADKKKIGEVIEEL-DEKKK 766
                 233333333444444444444444444433333..........03333333333434444448888899999999999999999999998664.45667 PP

      AAA_23 186 eeleeeleeilk 197
                 +++e++++++++
  EFC38631.1 767 KTIEDTWKKVDE 778
                 777877777665 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.1   3.9e-08   7.8e-05      24      48 ..      27      51 ..      14      62 .. 0.81

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 3.9e-08
      AAA_29 24 atlltGpsGsGKSTllDAiqalLvp 48
                +  +tG +GsGKS +lDAi ++L  
  EFC38631.1 27 FNAITGLNGSGKSNILDAICFVLGI 51
                679******************9965 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   0.0   0.00016      0.31      15      35 ..      29      49 ..      23     144 .. 0.72
   2 ?  -12.0  16.7         9   1.8e+04      37      51 ..     272     286 ..     177     392 .. 0.55
   3 ?   -4.4   8.0         9   1.8e+04      21     102 ..     394     498 ..     387     518 .. 0.56
   4 !   12.7   0.0     7e-05      0.14      47     134 ..     744     855 ..     717     858 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00016
                EEEESTTSSHHHHHHHHTTSS CS
                xxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran 15 aivGenGaGKStLlkllagll 35
                ai+G nG+GKS +l +++  l
  EFC38631.1 29 AITGLNGSGKSNILDAICFVL 49
                8***************98654 PP

  == domain 2  score: -12.0 bits;  conditional E-value: 9
                 -SEEEEEETTCEGGG CS
                 xxxxxxxxxxxxxxx RF
    ABC_tran  37 pteGeilldgkdlke 51 
                  +e+ei+ + +++k+
  EFC38631.1 272 TEEDEIQKKIDSMKN 286
                 222222111111111 PP

  == domain 3  score: -4.4 bits;  conditional E-value: 9
                 TSSHHHHHHHHTTSS--SEEEEEETTCEGGG.B-HHHCCHCEEEE-SS--S-TTSBHHHH..........................HHHTCHHHHHHHS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx..........................xxxxxxxxxxxxx RF
    ABC_tran  21 GaGKStLlkllagllkpteGeilldgkdlke.qeleslrkeigvlpqepqlfpeltvren..........................esdeeiekalskl 92 
                 G GK+   +++  + + t+ +++++++ ++    ++ l+++ + l+ +++ + ++  +++                          + +eeie++ +k+
  EFC38631.1 394 GNGKTLTEQIMDCEKQITSLKVKINQNTVTLtYLKKGLEEKTSLLKTQSNEDTNI--KQHlqqlnesleeikkkledlnfneiiykQTEEEIEQIETKI 490
                 7788877777777777788888888666665433444444555544443332222..222332333344444445555566666555555566666655 PP

                 TTGGTTCBGE CS
                 xxxxxxxxxx RF
    ABC_tran  93 glkelkdtvv 102
                 + k+  +++v
  EFC38631.1 491 QEKK--NEIV 498
                 5444..4443 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 7e-05
                 CEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH........................HHHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  47 kdlkeqeleslrkeigvlpqepqlfpeltvren........................esdeeiekalsklglkelkdtvvksspssLSgGqkqrvalar 121
                 k    +  e  +k+ig + +e   ++++t++++                          ++ ++  l+ l+ k   +  +k+s ++LSgGq++ +al  
  EFC38631.1 744 K----DIVEADKKKIGEVIEELDEKKKKTIEDTwkkvdeyfrsifsmllvgasaklePPSDAVNGPLDGLEVKVAFNGAWKESLTELSGGQRSLLALSL 838
                 3....4456788888888888888888888888777777777777777776666555444446666777776667777777777*********999877 PP

                 HH....HHTSSEEEEES CS
                 xx....xxxxxxxxxxx RF
    ABC_tran 122 al....lkkpkllllDE 134
                 +l    +k +++++lDE
  EFC38631.1 839 ILsllrFKPAPVYILDE 855
                 66333367889999999 PP

>> MHB  Haemophore, haem-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.1   0.00035       0.7      11      63 ..     259     311 ..     252     316 .. 0.89
   2 ?   -3.1   0.0         5   9.9e+03      58      72 ..     448     462 ..     422     469 .. 0.54

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00035
         MHB  11 vvsgVaastsaYLdthPdvnqaltslkgqprdqaraavkaYfdanPqvaadLr 63 
                  + gV ++ ++Y+++  ++++ + s+k+q+++++++++++  ++    ++dL 
  EFC38631.1 259 KIEGVREQIEKYITEEDEIQKKIDSMKNQKQNRMKQDLNTLHNSLSSINKDLS 311
                 5679**********************************999888888888886 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 5
         MHB  58 vaadLrgIrqPltdl 72 
                  ++ L+++++ l+++
  EFC38631.1 448 IKQHLQQLNESLEEI 462
                 333333333333333 PP

>> SNCAIP_SNCA_bd  Synphilin-1 alpha-Synuclein-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.015        29      14      28 ..     334     348 ..     331     353 .. 0.84
   2 ?    5.1   1.6    0.0092        18      17      38 ..     437     458 ..     433     461 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.015
  SNCAIP_SNCA_bd  14 LTKQLkEQTaeRInl 28 
                     L KQL+E Ta R  l
      EFC38631.1 334 LEKQLEEETASREVL 348
                     78*********9655 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0092
  SNCAIP_SNCA_bd  17 QLkEQTaeRInlQkhlQrLlea 38 
                      Lk Q  e  n+ +hlQ+L e+
      EFC38631.1 437 LLKTQSNEDTNIKQHLQQLNES 458
                     6999***************876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (955 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3879  (0.216353); expected 358.6 (0.02)
Passed bias filter:                      636  (0.0354733); expected 358.6 (0.02)
Passed Vit filter:                       231  (0.0128842); expected 17.9 (0.001)
Passed Fwd filter:                       122  (0.00680462); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 2.36u 0.44s 00:00:02.80 Elapsed: 00:00:00.66
# Mc/sec: 4372.45
//
Query:       EFC38632.1  [L=328]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    6.8e-52  176.7   0.0    1.3e-50  172.4   0.0    2.0  1  PhzC-PhzF  Phenazine biosynthesis-like protein
  ------ inclusion threshold ------
      0.078   12.8   0.0       0.19   11.6   0.0    1.7  1  UBA_3      Fungal ubiquitin-associated domain


Domain annotation for each model (and alignments):
>> PhzC-PhzF  Phenazine biosynthesis-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  172.4   0.0   1.5e-54   1.3e-50       1     283 []      11     324 ..      11     324 .. 0.84

  Alignments for each domain:
  == domain 1  score: 172.4 bits;  conditional E-value: 1.5e-54
                 EEET-SSTTSSEEEEEEESTT.............CS-HHHHHHHHHHHTSSEEEEEE--SSTTSSEEEEEE-SSSEES--HHHHHHHHHHHHHHCT-S- CS
   PhzC-PhzF   1 vdaFtespfkGNpaaVvldad.............elddeelqsiAaelnlseTaFllkpsdekarfrlRyFTPvaEvdlcGHatlasahalaekglvas 86 
                 vdaFt+spf GNpa+V++++d             e  d+  + iA+e+nlseT+Fl +  +   r++lR+FTP+ Ev lcGHatla   +l+ ++   s
  EFC38632.1  11 VDAFTKSPFSGNPAGVCILEDseiksidqrfpseEEKDNFYKLIAREMNLSETCFLWRVGSSFDRYKLRWFTPTVEVSLCGHATLACSNILFGRLE--S 107
                 8********************************99999999***************************************************9995..7 PP

                 SCEEEEEETTEEEEE.EEEEETCEECCEEEEE-SEEEEEE-HHHHHHHHHHCCTSGG............-TTS-BEEEES.SSEEEEEEBSTCCHHHH- CS
   PhzC-PhzF  87 aetveletkaGilpvkslkekddgeellielkfPvikteevssedlallakllklaa............qkalpiavkst.glekvivplsseeavael 172
                  +++++etk+G+l+v       ++ +  ++++fP+ +++ v ++  +l++  +  +              +++++++  +  ++k+++ +++ + v  +
  EFC38632.1 108 VDKLFFETKSGELTV-------EKDNGILKMNFPQGDPQLVHQNGSSLFETSTLVELlkninitcenetINDIVSEILLCrKTRKLLIIVKDFHLVLCA 199
                 9**************.......45666778888888887777777777766666666556677887777455555555552467888888888888888 PP

                 ---H.........................HHHHHHCT-EEEEEEEETTTSSCCEEEEEEEEGGGTEEEESS-HHHHHHHHHHHHHCC-SSSEEEEEEEE CS
   PhzC-PhzF 173 spdl.........................aeeikkcpkkgvivtaaaeagskkdfhsRmFaPklGivEDpvtGsAsgaLaaylseklnleesakikieq 246
                 +p+                           +e+++ +kk  ++    ++ ++ d+  R+F+P  Gi+EDpv Gs + ++a y s+kln+      k+  
  EFC38632.1 200 EPNEqallsmdfknddlnanirgisvsmsVNEMSEENKKT-FTKMTTSDVNEIDYVTRYFSPWNGIKEDPVNGSSQTSMALYYSSKLNK-----KKLIC 292
                 88888999999999***99999999965434444433333.455667788899************************************.....89999 PP

                 -GGGT--EEEEEEEE.E-TTCEEEEEEEE-EEEEEEE CS
   PhzC-PhzF 247 gqalgrsgtlevevevkvdkekervkvtGkAvtvmeg 283
                 +qa++r+g l ve  ++      rv + G+A+t+m+g
  EFC38632.1 293 FQASKRTGILFVEP-IEG----GRVSIGGNATTIMQG 324
                 ***********554.444....6************97 PP

>> UBA_3  Fungal ubiquitin-associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   2.1e-05      0.19       9      54 ..     137     178 ..     136     179 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.1e-05
                 SHHHHHHHHHHT--HHHHHHHHHHS--SS--SS--HHHHHHHHHHT CS
       UBA_3   9 drdlVdefvsqGFekdkvievLkrLgiksldpednetankileELL 54 
                 d+ lV +  s  Fe+   +e Lk ++i      +net n i+ E+L
  EFC38632.1 137 DPQLVHQNGSSLFETSTLVELLKNINITC----ENETINDIVSEIL 178
                 678899999999***************98....79*********87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       777  (0.0433376); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.33s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 1966.43
//
Query:       EFC38633.1  [L=431]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.4e-06   26.9   1.5         49    4.3   0.0    3.6  2  TPR_12     Tetratricopeptide repeat
    0.00018   21.3   0.3        1.6    8.7   0.1    3.8  3  TPR_10     Tetratricopeptide repeat
    0.00022   20.9   3.6        2.7    7.9   0.0    4.5  4  TPR_1      Tetratricopeptide repeat
    0.00022   21.1   3.5        1.9    8.8   0.0    4.7  4  TPR_2      Tetratricopeptide repeat
    0.00082   19.0   0.6      0.002   17.7   0.6    1.7  1  IQ         IQ calmodulin-binding motif
     0.0041   17.2   5.8         25    5.4   0.1    5.2  5  TPR_8      Tetratricopeptide repeat
  ------ inclusion threshold ------
        1.1    9.2   4.3         27    4.7   0.1    3.9  4  DASH_Dam1  DASH complex subunit Dam1


Domain annotation for each model (and alignments):
>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.019        49      44      71 ..      86     113 ..      81     117 .. 0.86
   2 ?    4.3   0.0      0.02        51       6      44 ..     176     214 ..     171     221 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.019
      TPR_12  44 tattlrnLgrlyralgryeeAlelleea 71 
                 +++tl+n + +y + g++e  le l+ea
  EFC38633.1  86 LVSTLNNCSVYYKECGDLESSLESLQEA 113
                 6789999999999999999999999998 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.02
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhplt 44 
                  +n+a+ + +l +   A +++ k   +  ++lG dhp t
  EFC38633.1 176 FYNVAVEYEHLSQTLAAMDYYSKGFSLSLETLGADHPTT 214
                 568888899999************************987 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.0      0.01        26       3      28 ..      88     113 ..      86     113 .. 0.92
   2 !    8.7   0.1   0.00061       1.6      11      29 ..     131     149 ..     130     150 .. 0.89
   3 ?    3.1   0.0     0.035        90      21      41 ..     192     212 ..     177     213 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.01
      TPR_10   3 sslnNLanalrqrgrydeAealleea 28 
                 s+lnN ++++ + g+++ +++ l+ea
  EFC38633.1  88 STLNNCSVYYKECGDLESSLESLQEA 113
                 89*****************9999987 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00061
      TPR_10  11 alrqrgrydeAealleeal 29 
                 +l+q+gr++eA+++  eal
  EFC38633.1 131 VLSQMGRHEEALEHGTEAL 149
                 79***********988887 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.035
      TPR_10  21 AealleealairrrllGpdHP 41 
                 A++++ +  ++  ++lG+dHP
  EFC38633.1 192 AMDYYSKGFSLSLETLGADHP 212
                 77777788888889******9 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.1      0.35   8.9e+02      11      27 ..      47      63 ..      45      66 .. 0.88
   2 ?    2.9   0.1     0.041     1e+02      11      32 ..      97     118 ..      95     120 .. 0.87
   3 !    6.8   0.0    0.0024       6.1      10      23 ..     131     144 ..     129     151 .. 0.82
   4 !    7.9   0.0    0.0011       2.7       3      27 ..     175     199 ..     173     203 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.35
                HHHTT-HHHHHHHHHHH CS
       TPR_1 11 yfklgkydeAleyyekA 27
                + k+++ + +  + +kA
  EFC38633.1 47 LTKQKNKQSCKNCLQKA 63
                78999999999****99 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.041
                 HHHTT-HHHHHHHHHHHHHHST CS
       TPR_1  11 yfklgkydeAleyyekALelnP 32 
                 y + g+++  le  ++A +++ 
  EFC38633.1  97 YKECGDLESSLESLQEAQKHEK 118
                 8999*************99865 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0024
                 HHHHTT-HHHHHHH CS
       TPR_1  10 ayfklgkydeAley 23 
                 ++ ++g+++eAle+
  EFC38633.1 131 VLSQMGRHEEALEH 144
                 6889*********8 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0011
                 HHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekA 27 
                 a+yn ++ y +l +   A +yy+k 
  EFC38633.1 175 AFYNVAVEYEHLSQTLAAMDYYSKG 199
                 89********************996 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.12     3e+02      11      27 ..      47      63 ..      45      66 .. 0.87
   2 !    5.9   0.0    0.0061        16       4      31 ..      90     117 ..      87     120 .. 0.88
   3 !    8.8   0.0   0.00075       1.9      11      29 ..     132     150 ..     129     153 .. 0.89
   4 ?    1.0   0.0      0.23   5.9e+02       3      28 ..     175     200 ..     174     203 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.12
       TPR_2 11 yyklgdyeeAleafekA 27
                + k+++ + ++++++kA
  EFC38633.1 47 LTKQKNKQSCKNCLQKA 63
                6799************9 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0061
       TPR_2   4 lynlGlayyklgdyeeAleafekAleld 31 
                 l+n    y + gd+e  le +++A +++
  EFC38633.1  90 LNNCSVYYKECGDLESSLESLQEAQKHE 117
                 7888899*****************9876 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00075
       TPR_2  11 yyklgdyeeAleafekAle 29 
                 + ++g++eeAle+  +Al+
  EFC38633.1 132 LSQMGRHEEALEHGTEALR 150
                 7799*************98 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.23
       TPR_2   3 alynlGlayyklgdyeeAleafekAl 28 
                 a yn +  y++l +   A +++ k  
  EFC38633.1 175 AFYNVAVEYEHLSQTLAAMDYYSKGF 200
                 67999999999999999999999865 PP

>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.6   7.9e-07     0.002       2      21 .]     347     366 ..     346     366 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 7.9e-07
                 HHHHHHHHHHHHHHHHHHHH CS
          IQ   2 kaaikIQaawRGylaRkryk 21 
                   a+ IQ+++RGy +Rk+ +
  EFC38633.1 347 HKATEIQRVFRGYITRKKIR 366
                 57999************975 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1      0.07   1.8e+02      10      28 ..      46      64 ..      40      67 .. 0.88
   2 !    5.4   0.1    0.0096        25       8      28 ..      94     114 ..      87     118 .. 0.85
   3 ?    2.4   0.0     0.088   2.3e+02      11      22 ..     132     143 ..     131     151 .. 0.84
   4 ?   -1.0   0.0       1.1   2.9e+03       9      24 ..     153     168 ..     149     172 .. 0.78
   5 ?    4.8   0.0     0.016        40       3      31 ..     175     203 ..     173     206 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.07
                HHHHTT-HHHHHHHHHHHH CS
       TPR_8 10 iylklgdyeeAkeyyekal 28
                ++ k++++++ k +++ka 
  EFC38633.1 46 LLTKQKNKQSCKNCLQKAK 64
                78899************96 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0096
                 HHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   8 gsiylklgdyeeAkeyyekal 28 
                 +  y++ gd+e++ e++++a 
  EFC38633.1  94 SVYYKECGDLESSLESLQEAQ 114
                 5679**************996 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.088
                 HHHTT-HHHHHH CS
       TPR_8  11 ylklgdyeeAke 22 
                 ++++g++eeA e
  EFC38633.1 132 LSQMGRHEEALE 143
                 689*******87 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.1
                 HHHHHTT-HHHHHHHH CS
       TPR_8   9 siylklgdyeeAkeyy 24 
                  iy+kl+ +++ ++++
  EFC38633.1 153 EIYKKLNHIKNNIATC 168
                 69****9998876665 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.016
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleld 31 
                 a yn +  y+ l +  +A+ yy k  +l+
  EFC38633.1 175 AFYNVAVEYEHLSQTLAAMDYYSKGFSLS 203
                 67999*******************99886 PP

>> DASH_Dam1  DASH complex subunit Dam1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.1     0.032        81      12      36 ..     100     124 ..      97     125 .. 0.90
   2 ?    4.7   0.1      0.01        27      19      36 ..     155     172 ..     139     181 .. 0.81
   3 ?   -2.1   0.0       1.4   3.5e+03      32      38 ..     230     236 ..     214     236 .. 0.74
   4 ?   -1.5   0.0      0.85   2.2e+03       7      24 ..     337     354 ..     333     356 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.032
   DASH_Dam1  12 letLdknledLqqihesLsdfNeSF 36 
                   +L++ le Lq+ +++ ++fN S+
  EFC38633.1 100 CGDLESSLESLQEAQKHEKHFNASL 124
                 579*******************996 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.01
   DASH_Dam1  19 ledLqqihesLsdfNeSF 36 
                 +++L++i++++++ Ne +
  EFC38633.1 155 YKKLNHIKNNIATCNETL 172
                 689*************87 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.4
   DASH_Dam1  32 fNeSFas 38 
                 +N+SF+s
  EFC38633.1 230 MNKSFSS 236
                 6888887 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 0.85
   DASH_Dam1   7 eLaDsletLdknledLqq 24 
                 e++ +l++L+++ +++q+
  EFC38633.1 337 EIHNKLNELHHKATEIQR 354
                 566777777777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (431 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1536  (0.0856713); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.49u 0.23s 00:00:00.72 Elapsed: 00:00:00.37
# Mc/sec: 3532.74
//
Query:       EFC38634.1  [L=272]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-24   86.6   0.0    2.8e-24   86.0   0.0    1.3  1  PseudoU_synth_2  RNA pseudouridylate synthase


Domain annotation for each model (and alignments):
>> PseudoU_synth_2  RNA pseudouridylate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.0   0.0   1.6e-28   2.8e-24       1     159 [.      21     213 ..      21     214 .. 0.73

  Alignments for each domain:
  == domain 1  score: 86.0 bits;  conditional E-value: 1.6e-28
  PseudoU_synth_2   1 dlvvvnKPagvpvqpeak.........dgsekekettatssrae..eekkelklvhRLDkatsGllllAksseaanklakafeerkvrKkYlal 83 
                      d++v++KP++++ +++ +         +++e e+ +++ + ++   +  ++lk++h+LD+atsG+l+lA+++e ++k +  f++r+ +K+Yla+
       EFC38634.1  21 DVLVIDKPNDLHIDGDYEltveklinnYYPEMENPLEEIQHKPGhtPSRRKLKFCHQLDYATSGILCLAFTRESCAKITYPFQQRTAQKQYLAV 114
                      589***********************9888888888888888875567789******************************************* PP

  PseudoU_synth_2  84 vfgapeeeegaikkkiskdtekqegarrkaeeldgkkavtylkvlksgs.........................seksakvslveleletGrkh 152
                      ++g+   +  +i + i +d  ++ ++r+  ++l+ +k+       +                            ++   +v++v l+++tGr+h
       EFC38634.1 115 LRGHVLINDFEILTFIGEDPSDERKFRMRNFYLGREKTLLSELNTE--EeiqeakksresltfgsvlcrgfyhkDNDTIPVTKVLLRPKTGRRH 206
                      **55555555555555555333333333333332222221111111..112333333333344444445558888999**************** PP

  PseudoU_synth_2 153 QiRvhla 159
                      Q+R h +
       EFC38634.1 207 QLRLHTQ 213
                      *****86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       307  (0.0171231); expected 358.6 (0.02)
Passed bias filter:                      286  (0.0159518); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1696.29
//
Query:       EFC38635.1  [L=1333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-10   40.0  11.7    5.1e-10   38.8  11.7    1.7  1  Zn_ribbon_17    Zinc-ribbon, C4HC2 type
      3e-08   34.2  29.3    0.00076   20.2   0.2    7.1  8  WD40            WD domain, G-beta repeat
      3e-08   33.9   8.0    1.8e-07   31.4   8.0    2.4  1  zinc_ribbon_16  Zinc-ribbon like family
     0.0048   17.2   0.4     0.0048   17.2   0.4    2.6  2  RWD             RWD domain
  ------ inclusion threshold ------
      0.015   14.9   0.2      0.074   12.6   0.2    2.2  1  ZirS_C          Zinc-regulated secreted antivirulence protein
      0.047   14.0   7.4       0.17   12.3   7.4    2.0  1  zf-RING_2       Ring finger domain
      0.052   14.3   3.1       0.22   12.3   3.1    2.2  1  zinc_ribbon_15  zinc-ribbon family


Domain annotation for each model (and alignments):
>> Zn_ribbon_17  Zinc-ribbon, C4HC2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.8  11.7     2e-13   5.1e-10       5      56 ..    1214    1263 ..    1210    1265 .. 0.93

  Alignments for each domain:
  == domain 1  score: 38.8 bits;  conditional E-value: 2e-13
  Zn_ribbon_17    5 ksCayCelavkgrvvlcgvCeHvlHasCarewfenddlaeCpsGCGckclek 56  
                     +C++C  +v+g+v +c++C+H  H + +++wf+n     Cp+GC ckc e 
    EFC38635.1 1214 IHCSLCRSPVRGVVSYCPNCNHGGHVEHLQNWFQNHS--TCPAGCDCKCSEF 1263
                    57*********************************99..**********875 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1         4     1e+04      10      21 ..      99     114 ..      95     114 .. 0.72
   2 !   17.4   1.2   2.4e-06    0.0062       5      38 .]     183     220 ..     180     220 .. 0.92
   3 ?   -2.9   0.3       5.9   1.5e+04      25      38 .]     253     265 ..     243     265 .. 0.62
   4 !   20.2   0.2     3e-07   0.00076       7      38 .]     283     317 ..     276     317 .. 0.83
   5 ?   -1.4   0.0         2   5.2e+03      13      38 .]     333     359 ..     326     359 .. 0.68
   6 !   11.1   0.1   0.00023      0.58       3      38 .]     387     426 ..     385     426 .. 0.74
   7 ?    2.7   0.0      0.11   2.7e+02       6      25 ..     743     761 ..     740     766 .. 0.90
   8 ?   -4.0   0.8         7   1.8e+04       9      24 ..    1237    1251 ..    1232    1260 .. 0.52

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 4
                 SSS....EEEEEEETT CS
        WD40  10 Hss....vtslafspd 21 
                 H+s    v++++fs+d
  EFC38635.1  99 HKSkkneVSCVQFSHD 114
                 5333456****99987 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 2.4e-06
                 EEEESS.SSEEEEEEETTSSE...EEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgaw...lasGsdDgtvriWd 38 
                 r++ +H  s++s+++sp+      +a++s Dg v iWd
  EFC38635.1 183 RSFQAHqRSINSISWSPHDLTnskIATCSGDGFVNIWD 220
                 7899**777*********999***999988*******9 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 5.9
                 EEEEETTSEEEEEE CS
        WD40  25 lasGsdDgtvriWd 38 
                 +as++ +  +riWd
  EFC38635.1 253 IASAH-NVDLRIWD 265
                 44545.55689998 PP

  == domain 4  score: 20.2 bits;  conditional E-value: 3e-07
                 EESSSS.EEEEEEETTSSE..EEEEETTSEEEEEE CS
        WD40   7 ltGHss.vtslafspdgaw..lasGsdDgtvriWd 38 
                 +++H + ++s+++sp +a   +++Gs+D+ v+iWd
  EFC38635.1 283 ISAHHPlISSMDWSPTNAHeiVTAGSMDKLVKIWD 317
                 46884589************77799*********9 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 2
                 EEEEEEETTSSEEEEEE.TTSEEEEEE CS
        WD40  13 vtslafspdgawlasGs.dDgtvriWd 38 
                 v+ +++ p g+ l+s s + + vr+W+
  EFC38635.1 333 VSKIRYTPFGKGLVSISkKEHQVRVWK 359
                 5556666667777632536999****6 PP

  == domain 6  score: 11.1 bits;  conditional E-value: 0.00023
                 EEEEEESS.SSEEEEE...EETTSSEEEEE.ETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtsla...fspdgawlasG.sdDgtvriWd 38 
                 ++  ++GH + +++l+   ++  g+ l+   s+D ++r+W+
  EFC38635.1 387 NISLFSGHtDEIRCLDfrvTDNIGNQLL-TwSKDMSIRFWN 426
                 566799**666****8555555555588.4599*******8 PP

  == domain 7  score: 2.7 bits;  conditional E-value: 0.11
                 EEESSSSEEEEEEETTSSEE CS
        WD40   6 tltGHssvtslafspdgawl 25 
                 ++ +H ++++ +fsp+g+++
  EFC38635.1 743 SFIAH-PISGARFSPSGDLI 761
                 7899*.************97 PP

  == domain 8  score: -4.0 bits;  conditional E-value: 7
                  SSSSEEEEE.EETTSSE CS
        WD40    9 GHssvtsla.fspdgaw 24  
                  GH  v +l+ + ++++ 
  EFC38635.1 1237 GH--VEHLQnWFQNHST 1251
                  66..9999554444444 PP

>> zinc_ribbon_16  Zinc-ribbon like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.4   8.0   6.9e-11   1.8e-07      56     124 ..    1200    1262 ..    1152    1263 .. 0.66

  Alignments for each domain:
  == domain 1  score: 31.4 bits;  conditional E-value: 6.9e-11
  zinc_ribbon_16   56 lslGtsdvtnkdskrksvvkevssskkrfekwlsfclscghgahashakewfsthsicpvadcncecke 124 
                      lsl ++    +++ +k++++  s  ++ +   +s+c +c+hg h +h ++wf++hs cp a c+c+c e
      EFC38635.1 1200 LSLQQH----QQQLPKKYIH-CSLCRSPVRGVVSYCPNCNHGGHVEHLQNWFQNHSTCP-AGCDCKCSE 1262
                      333322....3356777774.78889999999***************************.78*****75 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.4   1.9e-06    0.0048       4     100 ..     520     642 ..     518     660 .. 0.75
   2 ?   -3.8   1.5         6   1.5e+04      32      32 ..     818     818 ..     761     890 .. 0.59

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.9e-06
                 HHHHHHHHHHSTTTC..CCCH....T--EE--S-EEEEEEECECCCC....................TT-CEEEEEEEEE-SSTT.SS--EEEEEECC. CS
                 xxxxxxxxxxxxxxx..xxxx....xxxxxxxxxxxxxxxxxxxxxxxx................xxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxx. RF
         RWD   4 eqEleaLesIypdef..evie....nenysikleikikldededeedse................feekkkpslkleiklpeeYP.eeaPiislsste. 78 
                 + E+e LesI  +    ++++    +++ + ++e+k+++++  ++e+                   +  + ++lkl+i++p+ YP   +P +++  ++ 
  EFC38635.1 520 DSEVEKLESILNNLKfcTRVKtgatEKPENNECELKLNIEKIDKREQARscilniiliiksvsvpNTPPTINELKLKITFPKLYPvGAPPSFEFIQSRs 618
                 579********98887855556776555555566777777776666655************999988999999************77788998777776 PP

                 SS-HHHHHHHHHHHHHHHHHT..T CS
                 xxxxxxxxxxxxxxxxxxxxx..x RF
         RWD  79 nlpkeqvksleekleelaeen..l 100
                  ++ +++k +++ l + a e+  +
  EFC38635.1 619 FISVNDLKIIKQALTSAAHEDvlK 642
                 778888888888888877776652 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 6
                 E CS
                 x RF
         RWD  32 i 32 
                  
  EFC38635.1 818 K 818
                 0 PP

>> ZirS_C  Zinc-regulated secreted antivirulence protein C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.2   2.9e-05     0.074      14     102 ..     226     321 ..     224     328 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.9e-05
                 ----------------------SSSS-----B-GGG-EEE-----B-TT-EEEEEE.......E-BBTTS-B------B--EE-S-SSSEEEE--- CS
      ZirS_C  14 netdiasasgytpvpsvsefqyietetisntpspdltlisidkavlspgesatitt.......lvkdvdgnpvnevminkavarenlkglwdigpl 102
                 n+  +as   yt  ps+   + i+++ i+ +   dl + +i ++  s   s   tt       l+  +d  p n   i  a + ++l  +wd+   
  EFC38635.1 226 NQCKVASFISYTDFPSIVCWNPIDSNIIASAHNVDLRIWDIRNCSSSSTPSNKFTTfisahhpLISSMDWSPTNAHEIVTAGSMDKLVKIWDYTEQ 321
                 678899999*************************************9999999998333333345789************************9765 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   7.4   6.5e-05      0.17       2      42 ..    1215    1254 ..    1214    1257 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.5e-05
   zf-RING_2    2 eCpICleelssadsvlllpCgHvfhreClerwlrssstCPl 42  
                   C++C +++    s++   C+H  h e l++w++++stCP+
  EFC38635.1 1215 HCSLCRSPVRGVVSYCP-NCNHGGHVEHLQNWFQNHSTCPA 1254
                  6*****99965455444.4*********************7 PP

>> zinc_ribbon_15  zinc-ribbon family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   3.1   8.7e-05      0.22      35      85 ..    1174    1233 ..    1144    1234 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 8.7e-05
  zinc_ribbon_15   35 kpylacskCkslleaskelgkeiekkesse.........kkeCknCgkeveeefkyCpkC 85  
                      + +  +s+C+  +e+   l+++ +++ s +         + +C+ C++ v   ++yCp+C
      EFC38635.1 1174 RFMNGTSECSIDIESVPILNEQYRRNLSLQqhqqqlpkkYIHCSLCRSPVRGVVSYCPNC 1233
                      45555667777776666666666555555566778888899******************* PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2408  (0.134308); expected 358.6 (0.02)
Passed bias filter:                      559  (0.0311785); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.05u 0.33s 00:00:01.38 Elapsed: 00:00:00.50
# Mc/sec: 8000.35
//
Query:       EFC38636.1  [L=615]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-07   30.7  14.7    3.9e-07   30.1  14.7    1.3  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
        0.3   11.1   1.6       0.59   10.2   1.6    1.5  1  AT_hook   AT hook motif


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1  14.7   4.4e-11   3.9e-07       1      38 [.     453     489 ..     453     491 .. 0.94

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 4.4e-11
                 SS-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus   1 haCdnCrkkKvKCdakkPaCsnCkklnleCtfysessk 38 
                 ++C +Cr+ + +C++++P C +C++l+++C++ +e+++
  EFC38636.1 453 RSCSECRRVHKRCSKERP-CLRCVRLGKKCVDLPEKKR 489
                 59****************.************9999987 PP

>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   1.6   6.6e-05      0.59       2      10 ..     487     495 ..     486     497 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 6.6e-05
     AT_hook   2 RkRGRPrKa 10 
                 +kRGRP+K 
  EFC38636.1 487 KKRGRPKKI 495
                 9******95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (615 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       876  (0.0488594); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 3902.45
//
Query:       EFC38637.1  [L=486]
Description: hypothetical protein NAEGRDRAFT_73664 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0022   18.0  13.8     0.0078   16.3   6.8    5.8  5  APC_N_CC        Coiled-coil N-terminus of APC, dimerisation d
     0.0025   17.4  20.5     0.0025   17.4  20.5    4.1  4  CENP-K          Centromere-associated protein K
  ------ inclusion threshold ------
      0.019   15.2  12.1      0.019   15.2  12.1    5.6  5  ATG16           Autophagy protein 16 (ATG16)
      0.083   12.9  89.9        1.2    9.1  17.1    4.9  4  CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein C
        3.9    7.3   6.4        3.8    7.4   0.3    3.6  3  Lipoprotein_19  YnbE-like lipoprotein
        5.1    7.3  23.1       0.67   10.1   0.8    5.3  5  MbeD_MobD       MbeD/MobD like


Domain annotation for each model (and alignments):
>> APC_N_CC  Coiled-coil N-terminus of APC, dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.49   1.5e+03      23      41 ..      52      70 ..      41      73 .. 0.83
   2 !   16.3   6.8   2.6e-06    0.0078       6      47 ..      75     116 ..      71     123 .. 0.86
   3 !   14.3   0.6   1.1e-05     0.033       3      33 ..     187     217 ..     185     226 .. 0.83
   4 ?   -2.0   1.6       1.3     4e+03       6      36 ..     345     375 ..     344     385 .. 0.67
   5 ?   -1.4   2.8      0.83   2.5e+03      11      25 ..     427     441 ..     391     462 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.49
    APC_N_CC 23 ELedNSshLskLEtetsgm 41
                EL   S  + + E+et+++
  EFC38637.1 52 ELVKRSLDIAREEKETLNL 70
                777888999999****998 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 2.6e-06
    APC_N_CC   6 LvrQvEaLkkenthlrrELedNSshLskLEtetsgmKevlkq 47 
                 L +QvE Lk +   l +E+e+NS++ sk E + + + + lk+
  EFC38637.1  75 LKQQVELLKNDKMYLTKEIENNSNKSSKNEDDILRLENKLKE 116
                 779***************************999876555554 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 1.1e-05
    APC_N_CC   3 YdQLvrQvEaLkkenthlrrELedNSshLsk 33 
                  + L rQvE+Lk +nt+   E +   s L k
  EFC38637.1 187 VEKLKRQVEDLKETNTNVMMEFRTLQSTLEK 217
                 57899************99998876666655 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.3
    APC_N_CC   6 LvrQvEaLkkenthlrrELedNSshLskLEt 36 
                 L+r v +L k+ t+ r   +   s +s L  
  EFC38637.1 345 LARKVSDLEKQLTEKREKEKKDQSTISMLTE 375
                 7899999999999877444444556676654 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 0.83
    APC_N_CC  11 EaLkkenthlrrELe 25 
                   Lk++n +l + Le
  EFC38637.1 427 DKLKRTNIKLEQDLE 441
                 457777777777776 PP

>> CENP-K  Centromere-associated protein K
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7  20.5    0.0064        19      77     172 ..      33     128 ..       1     135 [. 0.77
   2 ?   -3.7  17.8       2.4   7.1e+03      82     163 ..     141     224 ..     126     236 .. 0.54
   3 !   17.4  20.5   8.5e-07    0.0025      34     167 ..     239     411 ..     223     415 .. 0.89
   4 ?   -0.7   9.5      0.29   8.7e+02      81     148 ..     405     471 ..     397     484 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0064
      CENP-K  77 eevllalgkeelqklksqLelvlsiiqsknkklkedLkrEqewleeqqeilesLke.ktkelkkqvvafsektrksaelkekirkikeykeeLltaL 172
                  ++   + +ee +k +s+Lelv   ++  +++ ke L+ E + l++q e+l+  k   tke++++  + s+++  +  l++k +++++ k+ L  +L
  EFC38637.1  33 VKLKASNYEEEARKCQSELELVKRSLDIAREE-KETLNLELTNLKQQVELLKNDKMyLTKEIENNSNKSSKNEDDILRLENKLKEMRKEKKTLYDKL 128
                 2334557799******************9887.99**************99887652689999999999999889*************9*9999887 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 2.4
      CENP-K  82 algkeelqklksqLelvlsiiqsknkklkedLkrEqewleeqqe....ilesLkektkelkkqvvafsektrk.saelkekirkike 163
                  + +ee+qklk++ +  l ii   +++ +e+ +rE ++l+e ++     +e Lk++ ++lk++++++  + r+  + l+++i +i++
  EFC38637.1 141 RSLQEEIQKLKEKTQKDLDII---KQNSQENYERENRMLKESKDgaeaQVEKLKRQVEDLKETNTNVMMEFRTlQSTLEKQISEIRT 224
                 244566666644433333333...445566666776666666541111445567777777777776666666634455555555555 PP

  == domain 3  score: 17.4 bits;  conditional E-value: 8.5e-07
      CENP-K  34 s.llgtetlvesdaqlslliarvklLtaeleqwekktpeiislneevllalgke..elqklksqLelvlsiiqsk........................ 105
                 s +  +e+l++s++++++++ ++ +L+ e+  ++++t + i+  e  l a++ke  + + l+++L+ v+++                            
  EFC38637.1 239 SlMEHAENLKQSKIESEIMKKKLDVLKTEYYSLQNSTGKKITELETTLSAVTKElnQYRDLERDLDKVIETYSPDyqekdgherilseltalvptnmgr 337
                 323458******************************************9999964478899**********98777888******************** PP

      CENP-K 106 ...........nkklkedLkrEqewleeqqeilesLkektkelkkqvvafsektrk.saelkekirkikeykee 167
                              +l+++L++ +e  ++ q+ ++ L+e+ +++kkq ++ s+     ++ l++k r+++ +++e
  EFC38637.1 338 rvkyslylarkVSDLEKQLTEKREKEKKDQSTISMLTERLNKMKKQFETSSKPYNYlVTSLEDKDREVELMRKE 411
                 *********99899*********************************999998665799999999998877665 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 0.29
      CENP-K  81 lalgkeelqklksqLelvlsiiqsknkklkedLkrEqewleeqqeilesLkektkelkkqvvafsekt 148
                 ++l ++e++ ++++L+ + +  + k k+ + +L+++ e l eq+++++ L     ++k+++++f+ + 
  EFC38637.1 405 VELMRKEFKVIEKDLKHFKKE-NDKLKRTNIKLEQDLEKLLEQKSVTSKLRDLLVNMKQDQENFNPSA 471
                 678889999999999988764.34566666679999999999*********99999999999998765 PP

>> ATG16  Autophagy protein 16 (ATG16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4  11.6    0.0015       4.6     114     181 ..      19      86 ..       2      93 .. 0.89
   2 ?   -8.4  36.5         6   1.8e+04      14     169 ..      66     217 ..      62     226 .. 0.55
   3 ?   -5.2  20.9         6   1.8e+04      32     164 ..     141     272 ..     137     276 .. 0.47
   4 ?   -4.3  14.1       5.9   1.8e+04      33     155 ..     189     309 ..     186     317 .. 0.53
   5 ?   15.2  12.1   6.3e-06     0.019     100     184 ..     345     429 ..     339     448 .. 0.93

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0015
       ATG16 114 leeklkedeerlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnqaEeklrklekEN 181
                   e++k+++e  ++++ + ++ e++ ++ + el+  ++ +++ ++E ++L+l+l+ + ++ + l+++ 
  EFC38637.1  19 MVEEIKTKSEMFDAVKLKASNYEEEARKCQSELELVKRSLDIAREEKETLNLELTNLKQQVELLKNDK 86 
                 56899********************************************************9999885 PP

  == domain 2  score: -8.4 bits;  conditional E-value: 6
       ATG16  14 ekafaeliqaynrLldrtsaleaenaklekaaasakssksskksakekeasasqsnskqsakiqsleqklaqlreel.aelyksrgelaqrllelnee. 110
                 e+++ el    ++L +++++l+  +  l k+++++++++s+++++  +++++    ++ +++ ++l +kl+++ree  +e  +s +e  q+l+e++++ 
  EFC38637.1  66 ETLNLEL----TNLKQQVELLKNDKMYLTKEIENNSNKSSKNEDDILRLENKL---KEMRKEKKTLYDKLLSTREESkTEYERSLQEEIQKLKEKTQKd 157
                 5555555....678888888888888887777766663333333333333333...3566666777777777777751455555555555555554431 PP

       ATG16 111 lqk.leeklkedeerlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnq 169
                 l+  ++++ ++ e++ + l++++   e ++++++ +++++++++ ++  E  +Lq +l++
  EFC38637.1 158 LDIiKQNSQENYERENRMLKESKDGAEAQVEKLKRQVEDLKETNTNVMMEFRTLQSTLEK 217
                 333122333333455555666666666666666666666666666666666666665554 PP

  == domain 3  score: -5.2 bits;  conditional E-value: 6
       ATG16  32 saleaenaklekaaasaks..sksskksakekeasasqsnskqsakiqsleqklaqlreelaelyksrgelaqrllelneelqkleeklkedee....r 124
                 ++l++e +kl++++++     +++s+  ++ ++     +n   +++    e+++ +l+ ++++l  +++      ++l+++l+k+ ++++++++     
  EFC38637.1 141 RSLQEEIQKLKEKTQKDLDiiKQNSQ--ENYER-----ENRMLKESKDGAEAQVEKLKRQVEDLKETNTNVMMEFRTLQSTLEKQISEIRTQANlkifD 232
                 45666666665554444443222222..11111.....2333455555566666666666666666666666666666666666666666554321112 PP

       ATG16 125 laeleaeraaletklkdreeelrekeklvqdlqDElsaLq 164
                  ++l+ +  +  ++lk+ + e +  +k ++ l+ E+ +Lq
  EFC38637.1 233 NERLQVSLMEHAENLKQSKIESEIMKKKLDVLKTEYYSLQ 272
                 2233333333334444444444445555566666666665 PP

  == domain 4  score: -4.3 bits;  conditional E-value: 5.9
       ATG16  33 aleaenaklekaaasaks..sksskksakekeasasqsnskqsakiqsleqklaqlreelaelyksrgelaqrllelneelqkleeklkedeerlaele 129
                 +l+++ + l++  +++    ++ +++ +k+ ++ ++q     + ki + e + ++l e  ++l +s+ e++ + ++l     +  +  ++  +++ ele
  EFC38637.1 189 KLKRQVEDLKETNTNVMMefRTLQSTLEKQISEIRTQ----ANLKIFDNERLQVSLMEHAENLKQSKIESEIMKKKLDVLKTEYYSLQNSTGKKITELE 283
                 4444444443322222223322222222333222222....4445555555555555555555555555554444444444444445556678899999 PP

       ATG16 130 aeraaletklkdreeelrekeklvqd 155
                 ++ +a++++l++ ++  r+++k++++
  EFC38637.1 284 TTLSAVTKELNQYRDLERDLDKVIET 309
                 99999999999999999999999886 PP

  == domain 5  score: 15.2 bits;  conditional E-value: 6.3e-06
       ATG16 100 laqrllelneelqkleeklkedeerlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnqaEeklrklekENkeL 184
                 la ++ +l+++l +++ek k+d++++  l+++ ++++++ +   +  + + + ++d   E++ ++ +++ +E+ l+  +kEN +L
  EFC38637.1 345 LARKVSDLEKQLTEKREKEKKDQSTISMLTERLNKMKKQFETSSKPYNYLVTSLEDKDREVELMRKEFKVIEKDLKHFKKENDKL 429
                 688999**********************************999999999999999999999999999999999999999999988 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3  31.6     0.013        38       7     140 .]      18     152 ..      11     152 .. 0.91
   2 ?    9.1  17.1    0.0004       1.2       2      81 ..     140     221 ..     139     242 .. 0.83
   3 ?    7.1   4.7    0.0017       5.1       8      68 ..     243     303 ..     238     318 .. 0.82
   4 ?    8.4  18.6   0.00068         2       2     102 ..     353     449 ..     349     474 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.013
  CENP-F_leu_zip   7 hvlekLKeserkadsLkdkvenLerelemseenqekvileaEtskaevetlkeeieelaeelreleldLvalrsekeeLekelqkkqervseLes 101
                      + e+ K   +  d +k k+ n e e    ++++e v++  + +++e etl+ e+ +l+++ + l+ d   l++e e+  ++  k+ + +  Le+
      EFC38637.1  18 VMVEEIKTKSEMFDAVKLKASNYEEEARKCQSELELVKRSLDIAREEKETLNLELTNLKQQVELLKNDKMYLTKEIENNSNKSSKNEDDILRLEN 112
                     5789999999999*****************************************99999999999999999999999999999999999999999 PP

  CENP-F_leu_zip 102 lnsslenlleekEqekvqmkeeskaave.eLqtqlkelne 140
                        ++++  + + ++    +eesk++ e +Lq ++++l+e
      EFC38637.1 113 KLKEMRKEKKTLYDKLLSTREESKTEYErSLQEEIQKLKE 152
                     99999999999999999999****9998469999999987 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0004
  CENP-F_leu_zip   2 ekkklhvlekLKeserk.adsLkd.kvenLerelemseenqekvileaEtskaevetlkeeieelaeelreleldLvalrse 81 
                     e+  ++  +kLKe  +k  d +k+   en ere  m++e+++ ++ ++E+ k +ve lke   +   e r l++ L++  se
      EFC38637.1 140 ERSLQEEIQKLKEKTQKdLDIIKQnSQENYERENRMLKESKDGAEAQVEKLKRQVEDLKETNTNVMMEFRTLQSTLEKQISE 221
                     566788899***9765516888761579*********************************999999999999998876665 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0017
  CENP-F_leu_zip   8 vlekLKeserkadsLkdkvenLerelemseenqekvileaEtskaevetlkeeieelaeel 68 
                      +e+LK+s+ +++ +k k + L+ e   ++++  k i+e Et   +v +  ++ + l++ l
      EFC38637.1 243 HAENLKQSKIESEIMKKKLDVLKTEYYSLQNSTGKKITELETTLSAVTKELNQYRDLERDL 303
                     6799999999999999999999999999999999999999999888776555555555544 PP

  == domain 4  score: 8.4 bits;  conditional E-value: 0.00068
  CENP-F_leu_zip   2 ekkklhvlekLKeserkadsLkdkvenLerelemseenqekvileaEtskaevetlkeeieelaeelreleldLvalrsekeeLekelqkkqerv 96 
                     ek+  + +ek K+ ++  + L ++ ++++++ e+s +  + +++  E++  eve +++e + +++ l++++ + ++l++ + +Le++l+k     
      EFC38637.1 353 EKQLTEKREKEKKDQSTISMLTERLNKMKKQFETSSKPYNYLVTSLEDKDREVELMRKEFKVIEKDLKHFKKENDKLKRTNIKLEQDLEKLL--- 444
                     4555677899999**********************************************999999999999999999999999999988732... PP

  CENP-F_leu_zip  97 seLesl 102
                      e +s+
      EFC38637.1 445 -EQKSV 449
                     .22333 PP

>> Lipoprotein_19  YnbE-like lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.2         1     3e+03      20      33 ..     189     202 ..     189     203 .. 0.86
   2 ?    1.0   0.1      0.12   3.6e+02      21      31 ..     299     309 ..     298     311 .. 0.89
   3 ?    7.4   0.3    0.0013       3.8      19      33 ..     434     448 ..     433     448 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1
  Lipoprotein_19  20 kvdkdvddlieenp 33 
                     k+ ++v+dl e+n 
      EFC38637.1 189 KLKRQVEDLKETNT 202
                     899*****998886 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.12
  Lipoprotein_19  21 vdkdvddliee 31 
                     +++d+d++ie+
      EFC38637.1 299 LERDLDKVIET 309
                     79*******97 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0013
  Lipoprotein_19  19 vkvdkdvddlieenp 33 
                     +k+++d+++l+e+++
      EFC38637.1 434 IKLEQDLEKLLEQKS 448
                     8***********986 PP

>> MbeD_MobD  MbeD/MobD like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.8   0.00022      0.67      17      63 ..      38      84 ..      24      91 .. 0.86
   2 ?    5.8   5.1    0.0048        14      16      63 ..     155     199 ..     122     206 .. 0.47
   3 ?   -0.7   0.1      0.53   1.6e+03      47      57 ..     345     355 ..     279     365 .. 0.62
   4 ?   -0.4   0.1      0.44   1.3e+03      42      59 ..     365     385 ..     344     392 .. 0.54
   5 ?   -0.6   0.1      0.51   1.5e+03      37      64 ..     419     446 ..     408     452 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00022
   MbeD_MobD 17 qdYeqrlqeWesafaelqrmfeltqrenaaLseqvtgLsqQVesLse 63
                 +Ye    + +s  +  +r  ++ + e+  L+   t+L qQVe L +
  EFC38637.1 38 SNYEEEARKCQSELELVKRSLDIAREEKETLNLELTNLKQQVELLKN 84
                6899999999999999***************************9976 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0048
   MbeD_MobD  16 QqdYeqrlqeWesafaelqrmfeltqrenaaLseqvtgLsqQVesLse 63 
                 Q+d    +q+ ++ ++   rm +  +      ++qv++L +QVe+L e
  EFC38637.1 155 QKDLDIIKQNSQENYERENRMLKESKD---GAEAQVEKLKRQVEDLKE 199
                 222222233333333333333322211...235566666666666655 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.53
   MbeD_MobD  47 LseqvtgLsqQ 57 
                 L  +v +L +Q
  EFC38637.1 345 LARKVSDLEKQ 355
                 33344444444 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.44
   MbeD_MobD  42 rena...aLseqvtgLsqQVe 59 
                 ++++   +L e+ +++ +Q e
  EFC38637.1 365 KDQStisMLTERLNKMKKQFE 385
                 222233366666666666655 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 0.51
   MbeD_MobD  37 feltqrenaaLseqvtgLsqQVesLseq 64 
                  ++ ++en +L+    +L q  e+L eq
  EFC38637.1 419 LKHFKKENDKLKRTNIKLEQDLEKLLEQ 446
                 5677889999999999999999998877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4046  (0.225668); expected 358.6 (0.02)
Passed bias filter:                      583  (0.0325172); expected 358.6 (0.02)
Passed Vit filter:                       201  (0.0112109); expected 17.9 (0.001)
Passed Fwd filter:                       105  (0.00585643); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 2.09u 0.45s 00:00:02.54 Elapsed: 00:00:00.71
# Mc/sec: 2059.02
//
Query:       EFC38638.1  [L=135]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (135 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1477  (0.0823805); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.51
# Mc/sec: 796.38
//
Query:       EFC38639.1  [L=630]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.016   14.7   0.6      0.028   13.9   0.6    1.3  1  RPN1_RPN2_N    RPN1/RPN2 N-terminal domain
      0.099   12.9   0.0        0.2   11.9   0.0    1.4  1  Ribosomal_L22  Ribosomal protein L22p/L17e


Domain annotation for each model (and alignments):
>> RPN1_RPN2_N  RPN1/RPN2 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.6   3.1e-06     0.028     170     286 ..      75     199 ..      45     204 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 3.1e-06
  RPN1_RPN2_N 170 eklvklvdeenyqrvclYLlscakylaepddvellrvafeiy....rklkkyseaLrvalrlndkelvkevfkaae.dklvkkQlayllarqqvklel 262
                   +l ++++  ++++ ++YL +c k++ + +  +++r ++ +y    +  ++  +a+++   ++++ l ++  k    d l  + l+ +++r+ v  + 
   EFC38639.1  75 RRLIRFIQGGDFEKAINYLNQCKKFIRDAEFNTVMRRILYAYfpclMLKGETARAMKLITDMENMGLYDQEAKLKYgDLLKFEKLSNVISREMVISKC 172
                  568899************************87666555444412226678999***************9999876549999999*******9999999 PP

  RPN1_RPN2_N 263 eeledededlnei.....lsneklsehfk 286
                  +e    ++dl++i      +n+++ ++++
   EFC38639.1 173 AEV--VTKDLENIedhygAENQDIPTKYE 199
                  965..444444441112234555555555 PP

>> Ribosomal_L22  Ribosomal protein L22p/L17e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   2.3e-05       0.2      12      66 ..      73     208 ..      64     222 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.3e-05
                    HHHHHHHHHTTSBHHHHHHHHHT-SST..................................................................... CS
  Ribosomal_L22  12 klrevarlIrgmkveeAlkyLkfskkk..................................................................... 38 
                    + r+++r I+g + e+A++yL++ kk                                                                      
     EFC38639.1  73 NKRRLIRFIQGGDFEKAINYLNQCKKFirdaefntvmrrilyayfpclmlkgetaramklitdmenmglydqeaklkygdllkfeklsnvisremv 168
                    66899******************9988999****************************************************************** PP

                    ...THHHHHHHHHHHHHHHH..HT.........-GGGEEE CS
  Ribosomal_L22  39 ...aakfvlklLknaeanaelkgl.........dvdslvI 66 
                        a+ v k L+n+e++   +++         d++sl+ 
     EFC38639.1 169 iskCAEVVTKDLENIEDHYGAENQdiptkyeklDPTSLIL 208
                    **999**********9998777776677777777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (630 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       664  (0.037035); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.47
# Mc/sec: 3998.48
//
Query:       EFC38640.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-40  138.8   0.4    3.6e-40  137.9   0.4    1.5  1  DNA_primase_S  DNA primase small subunit
  ------ inclusion threshold ------
       0.04   13.7   0.1         10    5.9   0.1    2.4  2  DUF1810        Protein of unknown function (DUF1810)


Domain annotation for each model (and alignments):
>> DNA_primase_S  DNA primase small subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.9   0.4     4e-44   3.6e-40       1     176 [.      74     307 ..      74     308 .. 0.77

  Alignments for each domain:
  == domain 1  score: 137.9 bits;  conditional E-value: 4e-44
                    EEEEEETTT-......TT--HHHHHHHHHHHHHHHHHHHH-----GGGEEEEE--SEEEEEEE--TTEEES-HHHHHHHHHH.............. CS
  DNA_primase_S   1 FDiDmddydd.....cseatvcekcwkfvsvavkvldellredfgfkdilwvfsgrrGfHcwvsdkdarpltdeeraaivnylnly.......... 81 
                    +DiD +dydd     c +  +c+ cw+ ++ a+++ld ll + fg k+++wv+sgrrG+Hcw sd+  + +++e r++i +++++y          
     EFC38640.1  74 IDIDISDYDDvrfcgCTGGKYCKQCWRLMNCAMEILDHLLVDVFGTKHLIWVYSGRRGIHCWASDELLKKMNNEGRSSISRFIHIYqsssiagekq 169
                    6*********************************************************************************************99 PP

                    ...........................................................HCHHHHCT--------..................... CS
  DNA_primase_S  82 .......rplhpflsrs..mlkivkpvveeiileeqdpf....................eikkllrllpdkslre.......kkkw.......eak 134
                           ++ hp+++ +   +  +++++ ei + + ++f                    e+k + + + ++ +         ++k+         +
     EFC38640.1 170 srrvnltGNAHPSFDIDsiVFTTCEKYFIEIFINDMGIFddelimqqsipyllnliyisEVKTMIQEILESGKSGtdiysqiRDKLlrdkknkHFL 265
                    999999955666665443555666666666666666666666666664444444443332222222222222222333333322224444444478 PP

                    ...........-----------------....---------. CS
  DNA_primase_S 135 edivlvllyprldeqvtkgikhllkapfcihgktgnvcvpld 176
                     +iv+++ yprld++v+kg++hllk+pfc+h+ tgn cvp++
     EFC38640.1 266 WEIVYSFVYPRLDVNVSKGFNHLLKSPFCVHPDTGNICVPIK 307
                    89**************************************95 PP

>> DUF1810  Protein of unknown function (DUF1810)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0    0.0017        16      13      40 ..     246     278 ..     234     287 .. 0.86
   2 ?    5.9   0.1    0.0011        10      83     121 ..     318     357 ..     309     358 .] 0.82

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0017
                 TTHHHHHHHHHTT---SS-HH.....HHS--BT CS
     DUF1810  13 kvyetalaelkaGrkrshwmW.....fvFPqlk 40 
                 + y+++ + l + +k+ h++W     fv+P+l+
  EFC38640.1 246 DIYSQIRDKLLRDKKNKHFLWeivysFVYPRLD 278
                 579******************999888999886 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0011
                 -S--HHHHS-TTHHHHHHHHHHHHHH.H-S--HHHHHHHH CS
     DUF1810  83 eeksaeeilGsidalKlrssmtLFae.vaedekvfkevld 121
                 ++ + +++l + d+ K+  s+ +F+e v++ +k fk+ ld
  EFC38640.1 318 HGARLHDLLSNNDKNKFSDSVKIFKEhVQSLSKSFKSSLD 357
                 5678899*****************9835555688888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       664  (0.037035); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 2016.66
//
Query:       EFC38641.1  [L=926]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.8e-12   46.8   3.5      6e-05   23.4   0.0    3.5  3  VWD        von Willebrand factor type D domain
  ------ inclusion threshold ------
      0.042   13.6   0.3         15    5.4   0.0    2.7  2  DUF3553    Protein of unknown function (DUF3553)
        0.5    9.9   2.1         40    3.8   0.1    3.4  2  DUF3343    Protein of unknown function (DUF3343)
       0.61   10.0   8.5        0.4   10.6   0.4    3.9  3  Ferritin   Ferritin-like domain


Domain annotation for each model (and alignments):
>> VWD  von Willebrand factor type D domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.1   3.6e-08   0.00016       1      88 [.      65     145 ..      65     219 .. 0.70
   2 !   23.4   0.0   1.3e-08     6e-05       1     121 [.     320     437 ..     320     449 .. 0.68
   3 ?   -0.5   0.3      0.29   1.3e+03      45      87 ..     815     856 ..     793     872 .. 0.77

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 3.6e-08
         VWD   1 CsvsgdphitTFDgakytfpgnctYvvlaqdcseqpdefsvnvtvkkedagqenvsclksvkvrvg.dveieltrrnkkvlvngqdvsl 88 
                 C+ +gdph tTF g++y+  g+ +Y+ la + + +     ++++++++++g  +v    ++ vrv+  ++ie + + +k  ++g++++ 
  EFC38641.1  65 CKSEGDPHLTTFGGVYYDHYGKGDYI-LASTEDGN-----FIAHSRTGQWGRVSV--NTAIAVRVNnMNTIEYNVEDDKFYLDGKEMNI 145
                 9999**********************.98886666.....777777777777555..56666666655555555555555555555554 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 1.3e-08
         VWD   1 CsvsgdphitTFDgakytfpgnctYvvlaqdcseqpdefsvnvtvkkedagqenvsclksvkvrvgdveieltrrn.kkvlvngqdvsl...plvnagk 95 
                 C+ +gdph++ F g+ y+f g+ +Yv la +++ +     ++++++++++g+ +v    +v v+++++ i  +  + +k  v+g++      ++ + g+
  EFC38641.1 320 CKSEGDPHYVDFRGRAYDFYGKGDYV-LAATKDGK-----FVAHSRTGRWGAVSV--NTAVAVKLNNDRIVEYNVEdDKFYVDGKEAVVevgKVNDLGN 410
                 9999**********************.88885555.....899999999999766..678888888666666655555666666554332233333333 PP

         VWD  96 ..eveilksgfvvvdvppgveltvdgdg 121
                   + ++  s++++++   +v+lt ++  
  EFC38641.1 411 gaSFKRV-SQTSMIVSLNDVHLTATWYR 437
                 4233333.56677777777777777766 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.29
         VWD  45 vkkedagqenvsclksvkvrvgdveieltrrnkkvlvngqdvs 87 
                 ++k  ++++++++++++k +  +++i ++r+   v+v+++ v+
  EFC38641.1 815 ANKAAKKAQKKTLKRALKPTPRRLTIAIKRA-SAVVVKKKTVK 856
                 4556666777778889998888********9.89999988876 PP

>> DUF3553  Protein of unknown function (DUF3553)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0    0.0032        15       2      28 ..      95     121 ..      94     124 .. 0.93
   2 ?    5.3   0.1    0.0035        16       3      28 ..     351     376 ..     350     378 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0032
     DUF3553   2 epGdlVrhPkqpdWGlGqVqSaiagrv 28 
                 e G+++ h     WG  +V+ aia rv
  EFC38641.1  95 EDGNFIAHSRTGQWGRVSVNTAIAVRV 121
                 679********************9998 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0035
     DUF3553   3 pGdlVrhPkqpdWGlGqVqSaiagrv 28 
                  G++V h     WG  +V+ a+a ++
  EFC38641.1 351 DGKFVAHSRTGRWGAVSVNTAVAVKL 376
                 59*******************99886 PP

>> DUF3343  Protein of unknown function (DUF3343)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1     0.009        40      14      31 ..     506     523 ..     499     524 .. 0.86
   2 ?    3.6   0.2      0.01        46      11      57 ..     814     862 ..     808     865 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.009
     DUF3343  14 aaekalkeggiearlipl 31 
                 +a k +k++gi+arl pl
  EFC38641.1 506 KATKTCKKAGISARLHPL 523
                 7899***********997 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.01
     DUF3343  11 hAiaaekalkeggiearliplPreis..agCGlalrvneedieeasrll 57 
                  A +a k ++++ ++  l p+Pr ++       a+ v+++ +++++r+l
  EFC38641.1 814 SANKAAKKAQKKTLKRALKPTPRRLTiaIKRASAVVVKKKTVKRIKRML 862
                 6789999999*************98854455555555666666666666 PP

>> Ferritin  Ferritin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.26   1.2e+03      97     116 ..     287     306 ..     256     334 .. 0.54
   2 ?    1.3   0.2     0.065   2.9e+02      80     128 ..     524     572 ..     480     585 .. 0.66
   3 ?   10.6   0.4   8.8e-05       0.4      30     108 ..     739     813 ..     736     829 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.26
                 HHHHHHHHHHHHTT-HHHHH CS
    Ferritin  97 eslrelielaeeegDpatad 116
                 e++ ++i+ +e++ D +   
  EFC38641.1 287 ETIAKVIKKVEKAADKKQKK 306
                 33333333333333333222 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.065
                 SHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
    Ferritin  80 sveevleaalehekkvteslrelielaeeegDpatadfledfleeqeeh 128
                   ++++++ ++  +k+ +++ ++i+  e+ +D +t    +++ + + + 
  EFC38641.1 524 AFRACVADQVQTGDKIGKKIAKVIAKLEKLHDKKTKKWTKKIKKAEKKA 572
                 4556666666677788888888888888888888888877777776554 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 8.8e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHTTS....SHHHHHHC-SSSSCSSHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Ferritin  30 leglaeffdeqaeeerehadklaerilalGgtpvltraeleeieapkefgsveevleaalehekkvteslrelielaee 108
                 l+++a  +++qa   r+  +kl+ r  + G + +++  +l++ +a      ++ + + a ++ +k  +++++l++ a++
  EFC38641.1 739 LRRIARRLKKQARKARKLVKKLLRRAEKTGKKSDIRAYKLAKKNA----RRARRAAKRACNRVNKKAKKINKLVKKAKK 813
                 78999**************************88888888887322....244444444444444444444444444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (926 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4565  (0.254615); expected 358.6 (0.02)
Passed bias filter:                      855  (0.0476881); expected 358.6 (0.02)
Passed Vit filter:                       434  (0.0242066); expected 17.9 (0.001)
Passed Fwd filter:                       138  (0.00769703); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 2.90u 0.41s 00:00:03.31 Elapsed: 00:00:00.67
# Mc/sec: 4148.89
//
Query:       EFC38642.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   4.8e-121  403.5   1.4     6e-121  403.2   1.4    1.1  1  Ribonuc_red_sm   Ribonucleotide reductase, small chain
  ------ inclusion threshold ------
      0.069   12.9   0.1       0.12   12.1   0.1    1.4  1  Haem_oxygenas_2  Iron-containing redox enzyme


Domain annotation for each model (and alignments):
>> Ribonuc_red_sm  Ribonucleotide reductase, small chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  403.2   1.4  6.6e-125    6e-121       1     279 []      28     295 ..      28     295 .. 0.99

  Alignments for each domain:
  == domain 1  score: 403.2 bits;  conditional E-value: 6.6e-125
                     TT-TTS-SSHHHHHHHHHHHCT---GGGS-GHHHHHHHHSTS-HHHHHHHHHHHHHHHHHHHHHHHCHHHCHHCCBSSHHHHHHHHHHHHHHHHH CS
  Ribonuc_red_sm   1 rfvlfpikypeiwelykkleanfWtpeevdlskDlkdwkekLsedekefikkvlaflalldtivnenlverllsevqipearafygfqaamEniH 95 
                     rfvlfp++yp+iwe+ykk++a+fWt+eevdl+ D+ +w  +L+++e++fik+vlaf+a++d+ivnenl ++++ evqipear+fygfq+a+EniH
      EFC38642.1  28 RFVLFPLEYPKIWEMYKKAMASFWTAEEVDLHTDITQWT-TLTPNEQHFIKSVLAFFAASDGIVNENLCQQFMAEVQIPEARCFYGFQIAIENIH 121
                     79************************************9.5****************************************************** PP

                     HHHHHHHHHHHT.-HHHHHHHHCHHHH-HHHHHHHHHHHHHHCTTTSCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHTTSSHHHHHHHHHHHHH CS
  Ribonuc_red_sm  96 aesYsllletlvkdekekdelfnaieenpalqkkaewikkwyeskkdeekfaerlvafallegilfysgFaailwlkkrgllpglaeiielilrD 190
                     ae+Ys+l+etl+kd+ e+++lfnai+++p++qkka+w++kw+++++    faerl+afa++egi+f+++F++i+wlkkrgl+pgla+++eli+rD
      EFC38642.1 122 AEMYSTLIETLIKDQRERHRLFNAIDTVPSVQKKARWAMKWINNENL---FAERLLAFACVEGIFFSGSFCSIFWLKKRGLMPGLAFSNELISRD 213
                     *******************************************9998...********************************************* PP

                     HHHHHHHHHHHHHHHHHCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTT.BTTCHHHHHHHHHHHHHHHHHHCTT---SS-TT---C CS
  Ribonuc_red_sm 191 eglHtdfagllfkelkeenelenkeleeeveelikeavelEkefitdalpvellglnkedvkqYieyvadrllmnlgyeklYnveeenP 279
                     eglHtdfa+ll+++l  +   ++k  ++ v++l+ eave+Ekefi+++lpv+l+g+n+++++qYie vadrll++lgy+k+Yn+   nP
      EFC38642.1 214 EGLHTDFACLLYSTL--K---FTKLPQQVVHSLVSEAVEIEKEFICESLPVDLIGMNSRLMQQYIEMVADRLLVSLGYDKIYNS--PNP 295
                     ***************..7...89************************************************************9..777 PP

>> Haem_oxygenas_2  Iron-containing redox enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.1   1.4e-05      0.12      82     167 ..      63     143 ..      41     151 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.4e-05
  Haem_oxygenas_2  82 inlfeavalsrrllgallGallalEllvsletlklaeelrelgldeeapeyfdlHvtiDnaHaamaleaviellateepeeqedvl 167
                       ++ +    +++++ ++l++++a  + v      + + + e++++ ea+ ++   + i+n Ha+m   ++ie l +++ +e+++++
       EFC38642.1  63 TQWTTLTPNEQHFIKSVLAFFAASDGIV--NENLCQQFMAEVQIP-EARCFYGFQIAIENIHAEMYS-TLIETLIKDQ-RERHRLF 143
                      45555556677888999**********9..33345555666****.899*****************8.9999999998.6666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       637  (0.035529); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 2161.11
//
Query:       EFC38643.1  [L=102]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.036   13.9   0.1      0.055   13.3   0.1    1.4  1  COX14     Cytochrome oxidase c assembly
      0.055   14.0   0.0      0.076   13.5   0.0    1.2  1  DUF2418   Protein of unknown function (DUF2418)
       0.11   12.8   0.0       0.16   12.2   0.0    1.3  1  Mac       Maltose acetyltransferase


Domain annotation for each model (and alignments):
>> COX14  Cytochrome oxidase c assembly
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.1   9.1e-06     0.055       8      55 ..       6      53 ..       1      61 [. 0.80

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 9.1e-06
       COX14  8 rlaDkaHrltVltLiGvTlyaggllvyt....vysygkynrkqkaelierek 55
                ++++++ ++  ++++G+T+ +    ++     +    ++ +k+k+    re+
  EFC38643.1  6 KVFNAIWKTATTAMVGFTVACFAAVGWEtknfIQNFSTWSEKRKQ----REA 53
                8999*******************9999989954455577777777....554 PP

>> DUF2418  Protein of unknown function (DUF2418)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   1.3e-05     0.076      45      79 ..      27      64 ..       6      68 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.3e-05
     DUF2418 45 vvllslql.ylli..skfeqqikDkkiiqkevleEYne 79
                 +++ + + ++++  s ++++ k ++ i+ke+++EYne
  EFC38643.1 27 FAAVGWETkNFIQnfSTWSEKRKQREAIAKEIMSEYNE 64
                2233333323333346678899***************8 PP

>> Mac  Maltose acetyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   2.7e-05      0.16      19      50 ..      50      77 ..      41      80 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 2.7e-05
                HH.HHHHHHHHHHHTSTTT-HHHHHHHHHHHSS CS
         Mac 19 eR.lrarelcrryNqtrpsdkdeRrelLrellG 50
                +R   a+e++ +yN     ++d+R + L+ ++G
  EFC38643.1 50 QReAIAKEIMSEYN-----EEDQRDRDLERIIG 77
                444789********.....99999998888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (102 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1477  (0.0823805); expected 358.6 (0.02)
Passed bias filter:                      788  (0.0439511); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 678.99
//
Query:       EFC38644.1  [L=558]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.1e-23   82.2  20.7    2.6e-05   24.9   0.2    7.4  7  WD40         WD domain, G-beta repeat
    1.6e-16   60.6   0.2    3.8e-16   59.3   0.2    1.7  1  NLE          NLE (NUC135) domain
    6.2e-09   36.0   2.5       0.03   14.6   0.0    4.4  4  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    6.4e-05   21.8   6.2      0.039   12.6   0.4    4.0  4  Nup160       Nucleoporin Nup120/160


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.5   1.5e-05     0.068      10      38 .]     169     211 ..     161     211 .. 0.79
   2 ?    1.1   0.1      0.19   8.6e+02      13      31 ..     228     261 ..     215     268 .. 0.55
   3 !   24.1   0.0     1e-08   4.6e-05       7      37 ..     282     313 ..     277     314 .. 0.91
   4 !   24.9   0.2   5.7e-09   2.6e-05       8      38 .]     373     403 ..     359     403 .. 0.77
   5 ?    4.0   0.1     0.024   1.1e+02       6      38 .]     412     446 ..     407     446 .. 0.68
   6 !   18.9   1.0   4.7e-07    0.0021       7      38 .]     458     489 ..     452     489 .. 0.89
   7 ?    3.3   0.0      0.04   1.8e+02      22      35 ..     537     551 ..     513     551 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.5e-05
                 S.SSEEEEE.............EETTSSEEEEEETTSEEEEEE CS
        WD40  10 H.ssvtsla.............fspdgawlasGsdDgtvriWd 38 
                 H ++v++l+             +s+d+++l+sG++Dg vr+ d
  EFC38644.1 169 HdDWVSALSlvthpsgadilssNSKDNQYLVSGCYDGVVRVID 211
                 75557777788888888888889*****************965 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.19
                 EEEEE..............EETTSSEEEEE.ETT CS
        WD40  13 vtsla..............fspdgawlasG.sdD 31 
                 +tsla              + ++g+ +++G ++D
  EFC38644.1 228 ITSLAtcyvtsqhlsdsdkTYSSGDIIIAGgGKD 261
                 6666666666666745555444444455553566 PP

  == domain 3  score: 24.1 bits;  conditional E-value: 1e-08
                 EESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   7 ltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 l GH ++v++++ +p g++++++s+D+++++W
  EFC38644.1 282 LNGHtDNVNDICLHPRGTMICTASEDRSLKLW 313
                 67**766************************* PP

  == domain 4  score: 24.9 bits;  conditional E-value: 5.7e-09
                 ESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                  GH  +++++++   g+ + sGs D+t+r+Wd
  EFC38644.1 373 NGHlLGINCVSWIEGGRIV-SGSSDHTIRVWD 403
                 389888****777777775.8988*******9 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.024
                 EEESSSSEEEEE..EETTSSEEEEEETTSEEEEEE CS
        WD40   6 tltGHssvtsla..fspdgawlasGsdDgtvriWd 38 
                 tl G + vts++    ++++ ++s++ D  +r+Wd
  EFC38644.1 412 TLNGSKVVTSISvrEKSESTTVLSSHPDFLIRMWD 446
                 555654467776554455555778999*******9 PP

  == domain 6  score: 18.9 bits;  conditional E-value: 4.7e-07
                 EESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   7 ltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 ++ H ++v+ +++ +d +++ sG+dD+ v++Wd
  EFC38644.1 458 FRSHrGWVRKVKWVSDFQFI-SGGDDNVVKLWD 489
                 789*999****999999997.7**********9 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.04
                 SSE.EEEEETTSEEE CS
        WD40  22 gaw.lasGsdDgtvr 35 
                 +++ l+sGs D+tv+
  EFC38644.1 537 SKYhLFSGSTDCTVK 551
                 3444679******98 PP

>> NLE  NLE (NUC135) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.3   0.2   8.6e-20   3.8e-16       3      64 ..      70     138 ..      68     139 .. 0.91

  Alignments for each domain:
  == domain 1  score: 59.3 bits;  conditional E-value: 8.6e-20
         NLE   3 vrFvtkdedeslavpgtplsvPasltrkqLselvnkLlk...ee.kpvpFdFlid....gel.lrtsLeeh 64 
                 v+F+t++    ++v+++ ++vP+++tr +Lse++n+L++   +e k+vpF+Fli+    +++ lrtsL+++
  EFC38644.1  70 VKFTTEQYP--IKVSENAFKVPSNFTRFGLSEVINQLIAqenDEhKHVPFEFLIEykpgKKIfLRTSLAKF 138
                 9*****877..****************************97633799***********96777*****997 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   6.6e-06      0.03      48      87 ..     193     231 ..     188     235 .. 0.88
   2 !    7.2   0.0    0.0014       6.1      36      80 ..     284     328 ..     263     337 .. 0.85
   3 !    5.1   0.1    0.0062        28      39      77 ..     377     414 ..     355     427 .. 0.77
   4 !    5.8   0.0    0.0039        17      37      78 ..     461     501 ..     443     516 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 6.6e-06
  ANAPC4_WD40  48 pdgklLavaysdgevrlldaesgkvvhslsvksekavtcl 87 
                  +d++ L+ ++ dg vr++d + gk+vh+ + ++   +t+l
   EFC38644.1 193 KDNQYLVSGCYDGVVRVIDTSLGKIVHQTKQSKVP-ITSL 231
                  6899*************************998874.7665 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0014
  ANAPC4_WD40  36 kedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvks 80 
                  ++  +v++++ +p g++++ a +d +++l ++  +++ ++l +++
   EFC38644.1 284 GHTDNVNDICLHPRGTMICTASEDRSLKLWEVDLARTRENLFYEN 328
                  57789**************************99999888876665 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0062
  ANAPC4_WD40  39 sevrsLaWkpdgklLavaysdgevrlldaesgkvvhsls 77 
                    +++++W + g+ ++ + sd ++r+ d+ +g+   +l+
   EFC38644.1 377 LGINCVSWIEGGR-IVSGSSDHTIRVWDVTTGTNSITLN 414
                  5689999987776.689**************98666554 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0039
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsv 78 
                  + + vr+++W  d +++  + +d+ v+l d+ sg  +hs + 
   EFC38644.1 461 HRGWVRKVKWVSDFQFI-SGGDDNVVKLWDIRSGIPIHSTPH 501
                  566799****9999987.6889***************99865 PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.1     0.016        70     223     259 ..     189     224 ..     173     278 .. 0.73
   2 !    4.3   0.0    0.0029        13     230     255 ..     298     323 ..     287     361 .. 0.72
   3 !   12.6   0.4   8.7e-06     0.039     176     277 ..     335     437 ..     329     461 .. 0.62
   4 !    4.1   0.0    0.0034        15     239     295 ..     482     542 ..     481     555 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.016
                 T.....TTTEEEEEETT-EEEEEETTTTEEEEEEE-- CS
      Nup160 223 vavveigqtylfalsrdgkLrvWnlltgkclatidll 259
                 ++ ++ +++yl++ + dg++rv +++ gk++ +   +
  EFC38644.1 189 SSNSK-DNQYLVSGCYDGVVRVIDTSLGKIVHQTKQS 224
                 44444.9*******************99999984444 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.0029
                 TTEEEEEETT-EEEEEETTTTEEEEE CS
      Nup160 230 qtylfalsrdgkLrvWnlltgkclat 255
                  t+++++s d+ L++W ++ +++ + 
  EFC38644.1 298 GTMICTASEDRSLKLWEVDLARTREN 323
                 59**************9986555444 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 8.7e-06
                 ETTEEEEEEEEE-------B--TTTT.TSS--SS---TT-ECEEEEET......TTTEEEEEETT-EEEEEETTTTEEEEEEE--....-SSSTT.S-- CS
      Nup160 176 dedggawkesvfepksfllslsgllglladpsrrksgasvalsldvavavvei.gqtylfalsrdgkLrvWnlltgkclatidll...rdeeaqd.ess 269
                 d+d++++ke +++ k++++ ++++      + +r ++ ++   l  ++ +v+  +   +++ s+d+++rvW+++tg+   t + +   +  ++   +s+
  EFC38644.1 335 DDDNEDYKEPSKKKKKMPSQIQQYAC--IGTLERNENENQNGHLLGIN-CVSWiEGGRIVSGSSDHTIRVWDVTTGTNSITLNGSkvvT-SISVReKSE 429
                 78889999999999999999999987..44445666666444444444.4433477778999*************97655544444532.222220233 PP

                 SSEESEEE CS
      Nup160 270 skstldpa 277
                 s + l+  
  EFC38644.1 430 STTVLSSH 437
                 33333334 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.0034
                 T-EEEEEETTTTEEEEEEE--.....-SSSTTS--SSEESEEESSSSEEEE.......... CS
      Nup160 239 dgkLrvWnlltgkclatidll....rdeeaqdessskstldpaesslirvsdggqsylvvt 295
                 d+++++W++++g ++ +   +    r+++++d++ s     p+e ++   s++gqs + ++
  EFC38644.1 482 DNVVKLWDIRSGIPIHSTPHSvnpeRKTISTDKVLSIEGFTPSEGQIKEQSQNGQSKYHLF 542
                 89*************99766667**99**********999*******99999999998885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (558 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.53
# Mc/sec: 3190.35
//
Query:       EFC38645.1  [L=432]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.2e-97  323.6   0.0    1.2e-96  323.2   0.0    1.1  1  E1_dh           Dehydrogenase E1 component
     0.0083   15.4   0.0      0.018   14.3   0.0    1.5  1  DXP_synthase_N  1-deoxy-D-xylulose-5-phosphate synthase
  ------ inclusion threshold ------
      0.039   14.1   0.0      0.078   13.2   0.0    1.5  1  YpM             Yersinia pseudo-tuberculosis mitogen


Domain annotation for each model (and alignments):
>> E1_dh  Dehydrogenase E1 component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  323.2   0.0    2e-100   1.2e-96       1     299 [.      97     396 ..      97     397 .. 0.99

  Alignments for each domain:
  == domain 1  score: 323.2 bits;  conditional E-value: 2e-100
                 HHHHHHHHHHHHHHHHHHTTSS-S-----TT-HHHHHHHHHTS-TTSEEEESS--HHHHHHTT--HHHHHHHHTT-TTTSSGTT-..-E..BTT..BEE CS
       E1_dh   1 eklvllrrvedaldalykrkkrigfyhlsagqealkvgiaaalekeDliiteYReagvllarglsleeilaeltgkvkgkggsrh.elmyaekesrilg 98 
                 +k+++  +++d++ ++++r++r++fy++++g+eal++g+a al ++D i+ +YReagvl+ rg +l+++l ++ +  ++ g++r+ +++y++ke ++ +
  EFC38645.1  97 YKTMIRLETMDDILYNAQRQGRVSFYMTNYGEEALQIGSASALSRDDTIFAQYREAGVLMHRGFTLDNFLNQCFSTIEDFGKGRQmPVHYGSKELNFQT 195
                 57899999******************************************************************************************* PP

                 E-SSTTTHHHHHHHHHHHHHHHTS---EEEEEEGGGTT-HHHHHHHHHHHHTT--EEEEEEEESEETTEEHHHH-S---GGG..TTTTS-EEEEETTSH CS
       E1_dh  99 gngivgaqvplvaGialaakiegkkevailliGDgAanqGdvyealnlaalwklpvifvveNNkygisTeaekasaskeladrargvgipglrVdgnDp 197
                 +++++++q p++aG+ +  +i+gk++v+++++G+gAa++Gd+++aln+a++ ++++if+++NN+y+isT+++ +++ + +++r+ g+gip++rVdgnD 
  EFC38645.1 196 ISSPLATQIPQAAGAGYVYRIQGKENVCVCYFGEGAASEGDFHAALNFASTLNCQTIFICRNNGYAISTPTRDQYHGDGIVARGIGYGIPSIRVDGNDL 294
                 *************************************************************************************************** PP

                 HHHHHHHHHHHHHHHTTT--EEEEEEE--SS-SSTTSHSHSSSHHHHHHHHHHHH-HHHHHHHHHHHTTSS-HHHHHHHHHHHHHHHHHHHHHHHHS-- CS
       E1_dh 198 lavyeAvkfAaeraregkgpllielvtYRyggHsesDdpstyrtreeveevrkkkdpiqrlkelLvkkgvvseeelkeiekevrkeveeavkkaeskke 296
                 +a y A+k A++   e kgp+lie++tYR+g+Hs+sDd+s+yr+ ee++++r++++pi r++++L k+ +++ee +k+ ++  rk v   ++k+e++++
  EFC38645.1 295 FASYLATKKARQLSIESKGPVLIEFMTYRAGHHSTSDDASRYRSNEELSKWRNEQNPIIRFRKYLEKNQLWNEEMEKTERDTNRKTVLSLLAKVEHAPK 393
                 **************************************************************************************************9 PP

                 --G CS
       E1_dh 297 lep 299
                 +++
  EFC38645.1 394 PHL 396
                 985 PP

>> DXP_synthase_N  1-deoxy-D-xylulose-5-phosphate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0     3e-06     0.018     114     178 ..     201     265 ..     188     268 .. 0.93

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3e-06
  DXP_synthase_N 114 stsisaalGlavardlkgekkkvvaviGDgaltgGmafealnnigelkkkllvilNdNemsiskn 178
                     +t i +a G     +++g+++ +v+  G+ga + G  + aln +++l+ + + i  +N  +is++
      EFC38645.1 201 ATQIPQAAGAGYVYRIQGKENVCVCYFGEGAASEGDFHAALNFASTLNCQTIFICRNNGYAISTP 265
                     5889999999999**********************************************999875 PP

>> YpM  Yersinia pseudo-tuberculosis mitogen
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   1.3e-05     0.078       5      54 ..     210     259 ..     204     265 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.3e-05
         YpM   5 atytgtiqgkgevciignkegktrggelyavlystnvnadmtlillrnvg 54 
                 a y   iqgk +vc+    eg +  g+++a l  +      t+ + rn g
  EFC38645.1 210 AGYVYRIQGKENVCVCYFGEGAASEGDFHAALNFASTLNCQTIFICRNNG 259
                 679999***********************999766655556777778866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       545  (0.0303977); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 2412.70
//
Query:       EFC38646.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.4    9.1   7.6        3.6    7.7   0.8    2.9  2  DUF3461   Protein of unknown function (DUF3461)


Domain annotation for each model (and alignments):
>> DUF3461  Protein of unknown function (DUF3461)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   1.0    0.0034        61      58     103 ..     199     246 ..     189     251 .. 0.82
   2 ?    7.7   0.8    0.0002       3.6      37      88 ..     502     553 ..     470     555 .] 0.79

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.0034
     DUF3461  58 lvdsgseeykevseis..avlrkvleeLdkltekkkeekdikekllkd 103
                 l    +e +k ++ei+  + l++ ++ +dk+  +++e+ d+  ++l++
  EFC38646.1 199 LITPTNEIFKALTEIEyeQALKQSMKGMDKVNLNDEEQLDLVAEILSE 246
                 55556778999998853378***********************99986 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0002
     DUF3461  37 ekgellaksvkfkfprqrkkvlvdsgseeykevseisavlrkvleeLdklte 88 
                 +k++  + s+ f fp   kk+++d + ++ ++++  ++ ++++++e+++l+e
  EFC38646.1 502 SKRSDRKSSLSFLFPGLYKKIQTDLKLKRLESTDPYKKPMNNIIQEMKSLVE 553
                 33444455788*************************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1794  (0.100061); expected 358.6 (0.02)
Passed bias filter:                      293  (0.0163422); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 3322.19
//
Query:       EFC38647.1  [L=723]
Description: kinesin-14 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.2e-43  147.2  16.2      1e-30  106.8   4.4    2.9  2  Kinesin       Kinesin motor domain
    6.3e-13   48.9   7.5    6.3e-13   48.9   7.5    3.3  2  Microtub_bd   Microtubule binding
    0.00012   21.3   0.1     0.0002   20.5   0.1    1.4  1  T2SSE         Type II/IV secretion system protein
     0.0012   19.2   0.6     0.0074   16.7   0.1    2.6  2  RNA_helicase  RNA helicase
     0.0077   16.6   0.0       0.18   12.2   0.0    2.6  2  AAA_16        AAA ATPase domain
     0.0091   16.4   0.1       0.17   12.3   0.0    2.6  2  AAA           ATPase family associated with various cellular 
  ------ inclusion threshold ------
      0.027   14.5   1.4      0.083   12.9   0.1    2.5  3  ResIII        Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.3   3.9   2.1e-15   5.3e-12      22     146 ..     408     542 ..     369     548 .. 0.72
   2 !  106.8   4.4     4e-34     1e-30     173     331 ..     547     713 ..     542     715 .. 0.85

  Alignments for each domain:
  == domain 1  score: 45.3 bits;  conditional E-value: 2.1e-15
                 C....................TCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHTT...SEEEEEEEESTTSSHHHHHTBCTT CS
     Kinesin  22 e....................ekkeeekkskkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvleG...ynatifaYGqtgsGKTyTmegkee 97 
                                       +k  +++ +   ++ ++ +f+Fdkvf+ +++++ev +++ ++++++v+     +  t++aYG+tgsGKTyT++    
  EFC38647.1 408 LegqiqdesnsvvatdetritIRKYLKNSVSGMGSKMSKYEFHFDKVFGYNTDNDEVTDSL-SNFIDRVVYDepqQRLTVLAYGATGSGKTYTINA--- 502
                 055555555555555555554666666777777889999*********************6.9999999975233689****************97... PP

                 TSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEEEEEETTEEEETTSTT CS
     Kinesin  98 eeeGiipraleelFesikkekeekekefsvkvsylEiYneeiyDLLesk 146
                     ++  + + lF+  k++         v  + +EiYne+   L++++
  EFC38647.1 503 ----VMNYVQNMLFSPEKSRIV-----RGVYFNCFEIYNEQTQLLISKD 542
                 ....688889999988766554.....4899999******998777765 PP

  == domain 2  score: 106.8 bits;  conditional E-value: 4e-34
                 EEESSHHHHHHHHHHHHHHHTSTTSSCTSHHCCSEEEEEEEEEEEETTTTTCEEEEEEEEEEEEEEECCCHHHHSS.............TCHHHHHHHH CS
     Kinesin 173 vevksaeevlellekgeknrkvaetklneeSSRSHavftitleqknlkeeteekvkisklnLvDLAGsErasktga.............aegerlkEaa 258
                 ++v+s++++ +l+ k++++rk+aet++n++SSRSH++++ ++   +++++         ln +DLAGsE++s+++               ++ r  E+ 
  EFC38647.1 547 IRVDSVQDLERLIIKSQNKRKCAETEYNKKSSRSHCIYRFKVCFDQQDDQ-----YYNVLNVIDLAGSEKLSSDEFiqnqtkdtsdfrdLKKMRNSETV 640
                 5799***************************************9997743.....4578***********98765333323334444443567889*** PP

                 HHHHHHHHHHHHHHHHHHTCCTSTSCGGGSHHHHHTGGGHSSSSEEEEEEEE-TBGG.....GHHHHHHHHHHHHHHC CS
     Kinesin 259 niNkSLlaLgrvisaLaekkkskhipYRdSkLTrlLqdsLgGnsktlmivtvspsse.....nleetlstlkfaerak 331
                 niNkSL++L++vi+ La+   sk+i YRdS LT++L++ L   s++++iv+++p ++     ++e+ +++l+fa++a+
  EFC38647.1 641 NINKSLSVLSQVIKGLAQG--SKFINYRDSVLTKILKNDL---SQVALIVNIKPPTQskdkiEIEKIVNSLTFAKKAN 713
                 *******************..*****************99...689******997664555578999********997 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.9   7.5   2.4e-16   6.3e-13       4     145 ..     345     535 ..     342     539 .. 0.77
   2 ?    0.7   0.3      0.18   4.5e+02      31      64 ..     563     596 ..     546     651 .. 0.83

  Alignments for each domain:
  == domain 1  score: 48.9 bits;  conditional E-value: 2.4e-16
                  HHHHHHHCHHHHH.HHCTB-EEEEEEECCCS-T...........EEEETTT............................................... CS
  Microtub_bd   4 eetlRrkleNtiq.elkGniRvfarvrpelesek..........akikfpe............................................... 43 
                  ++++R++l N i  e    i  ++rvr+ +++e                 +                                               
   EFC38647.1 345 DTSTRKTLRNVISfENSKFIKLYCRVRNYTQDELenvqknqtnlS-----Slithseanlsfesssqmlegqiqdesnsvvatdetritirkylknsv 437
                  5689********8566677***********998755555444440.....14444455556666778888889999999999999************* PP

                  ......TTTEEEE-SEEEECTTHCCCCCCCCHHHHHHHH.T..T--EEEEEEES................ST-HCHHHHHHHHHHCCTSCCCCEEEEE CS
  Microtub_bd  44 ...eekkkkkefsFdrvfeseseqeevfeeisqlvqsal.d..gynvcifaygqTGsGKtyTmegeeeeagmipraveeifetiselkekgwkyeiel 135
                       k +k+ef+Fd+vf  ++ ++ev++ +s +++ ++ d  +   +++ayg TGsGKtyT+++      +++ + +++f+  ++     +   +++
   EFC38647.1 438 sgmGSKMSKYEFHFDKVFGYNTDNDEVTDSLSNFIDRVVyDepQQRLTVLAYGATGSGKTYTINA------VMNYVQNMLFSPEKS----RIVRGVYF 525
                  **98899********************************862246799***************98......333333333333333....35666777 PP

                  EEEEEESS-E CS
  Microtub_bd 136 qfveiynekv 145
                  ++ eiyne+ 
   EFC38647.1 526 NCFEIYNEQT 535
                  7777777765 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.18
                  CCS-T.EEEETTT...TTTEEEE-SEEEECTTHC CS
  Microtub_bd  31 elesekakikfpeeekkkkkefsFdrvfeseseq 64 
                  +++++ a+ +++++ ++++  ++F  +f+++  q
   EFC38647.1 563 QNKRKCAETEYNKKSSRSHCIYRFKVCFDQQDDQ 596
                  3333447788888999999999**9999999865 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   7.9e-08    0.0002      28     156 ..     367     510 ..     348     550 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 7.9e-08
       T2SSE  28 rervdgielreveelekaalerlisria.alakldiseerplqdarlpekgvrlrvvllPvvagealviR...kksakeltlddlgaeealk....... 115
                   rv +  ++e+e+++k++++ l s i  + a+l+ ++++ +++++++ ++ +       ++ +++++iR   k+s++ +  +   +e +++       
  EFC38647.1 367 YCRVRNYTQDELENVQKNQTN-LSSLIThSEANLSFESSSQMLEGQIQ-DESNSV----VATDETRITIRkylKNSVSGMGSKMSKYEFHFDkvfgynt 459
                 456666556666666665554.44444404567788888888888888.322222....2345677777755444444442222222222224566777 PP

       T2SSE 116 ..........ekiaevlrkavrerglilvsGgTgsGKttllyallkeinks 156
                           + i++v+    ++r ++l  G+TgsGKt +++a+++++++ 
  EFC38647.1 460 dndevtdslsNFIDRVVYDEPQQRLTVLAYGATGSGKTYTINAVMNYVQNM 510
                 77888855555556666555599***********************99865 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.1   2.9e-06    0.0074       2     101 ..     487     583 ..     486     586 .. 0.75
   2 ?   -1.4   0.0       1.2   3.1e+03      53      85 ..     612     643 ..     605     646 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.9e-06
  RNA_helicase   2 wlyGpsgeGKStlakeLakallkklklkkkdsvysrnpeddfwdgYtgqevvvi.dDfgqvkdeenpsdlaelirlvsstpyplnmasleekgtlft 97 
                   + yG++g GK+++++ +++ +++ l +++k+++ +r++  + ++ Y++q+ ++i  D+ +       + +++l rl+   + + ++a+ e  +++ +
    EFC38647.1 487 LAYGATGSGKTYTINAVMNYVQNMLFSPEKSRI-VRGVYFNCFEIYNEQTQLLIsKDVDEFIRV---DSVQDLERLIIKSQNKRKCAETEYNKKSSR 579
                   68********************99966665555.89***********77665541555554433...567777777777777777777777777777 PP

  RNA_helicase  98 Skvv 101
                   S ++
    EFC38647.1 580 SHCI 583
                   7665 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.2
  RNA_helicase  53 vvidDfgqvkdeenpsdlaelirlvsstpypln 85 
                   +  d+f q++++ + sd+ +l ++ +s ++++n
    EFC38647.1 612 LSSDEFIQNQTK-DTSDFRDLKKMRNSETVNIN 643
                   567999999977.67799999999999888776 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.12   3.2e+02     114     151 ..     297     335 ..     213     358 .. 0.68
   2 !   12.2   0.0   7.1e-05      0.18      10      52 ..     466     518 ..     462     663 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.12
      AAA_16 114 aea...srllellkrllallsrderplvlvlDdlqwadeas 151
                 +++   +rl+e+  ++ +ll+++++  +l+lD  + + ++s
  EFC38647.1 297 EIEelkRRLFEQEEKFNDLLKEHQK--YLTLDRCDTLSDTS 335
                 2223559999999999999999777..******99666544 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 7.1e-05
      AAA_16  10 eqLlsalervrsgrp...elvllsGesGvGKsslvrellralekd.......g 52 
                 + L + ++rv  ++p     vl +G+ G+GK+  +++++++++         +
  EFC38647.1 466 DSLSNFIDRVVYDEPqqrLTVLAYGATGSGKTYTINAVMNYVQNMlfspeksR 518
                 6677888888888888889999*****************75554355555431 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.1      0.21   5.3e+02      41      98 ..     307     361 ..     286     389 .. 0.78
   2 !   12.3   0.0   6.7e-05      0.17       1      35 [.     486     520 ..     486     567 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.21
                 HHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH..TTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  41 esekkirelfkeakekakpsilfiDEidalaksr..sgseseeeervvnqLlteldgvkk 98 
                 e+e+k+++l+ke   +  ++ l +D  d l  ++  s++++++++++ ++L ++++ +++
  EFC38647.1 307 EQEEKFNDLLKE---H--QKYLTLDRCDTLSDTStlSTGSNQSDTSTRKTLRNVISFENS 361
                 455555555543...3..37799*******999999899999999999999999875555 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 6.7e-05
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCS CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsell 35 
                 vl yG  G GKT++++av++ ++  +++ + s+++
  EFC38647.1 486 VLAYGATGSGKTYTINAVMNYVQNMLFSPEKSRIV 520
                 689******************97666666655555 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       2.5   6.4e+03      96     119 ..     119     148 ..      64     175 .. 0.58
   2 ?   -2.0   0.1       1.2   3.1e+03      85     140 ..     369     424 ..     342     434 .. 0.48
   3 ?   12.9   0.1   3.2e-05     0.083      21      50 ..     474     509 ..     426     584 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.5
                 -.............-SEEEEEHHHHHHTH. CS
      ResIII  96 a......kekdstnkkilvttiqsldadse 119
                 +      +++ + +k+++++ ++s+   s 
  EFC38647.1 119 ScyqtpvQQSTAYKKRMIFSDYSSIGPCSV 148
                 044445556667778888888888877764 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.2
                 GEEEESSS-B--.......-SEEEEEHHHHHHTH.........HHHTTT-SEEEEET CS
      ResIII  85 igkkvsgdkkkakekdstnkkilvttiqsldadseee.eeeseellrdrfdviiiDE 140
                    ++++d+ ++  ++++++   ++t ++++ + e+  +  + + +++++ v+  DE
  EFC38647.1 369 RVRNYTQDELEN-VQKNQTNLSSLITHSEANLSFESSsQMLEGQIQDESNSVVATDE 424
                 344455555555.33333333334444444444433313333333333333665665 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 3.2e-05
                 ........TTSEEEEEESTTSTHHHHHHHHHHHH-S CS
      ResIII  21 s......krdkrglikmaTGtGKTlvaaklierllk 50 
                        +++  +l   aTG+GKT+++ +++ ++++
  EFC38647.1 474 RvvydepQQRLTVLAYGATGSGKTYTINAVMNYVQN 509
                 15555544555888999**********999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (723 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1213  (0.0676558); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.84u 0.38s 00:00:01.22 Elapsed: 00:00:00.58
# Mc/sec: 3759.93
//
Query:       EFC38648.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.4e-29  101.7   0.1    4.1e-29  101.4   0.1    1.1  1  CSN8_PSD8_EIF3K  CSN8/PSMD8/EIF3K family
     0.0015   18.0   0.0     0.0016   17.9   0.0    1.1  1  SAC3_GANP        SAC3/GANP family
     0.0082   16.6   0.0      0.013   16.0   0.0    1.4  1  PCI              PCI domain


Domain annotation for each model (and alignments):
>> CSN8_PSD8_EIF3K  CSN8/PSMD8/EIF3K family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.4   0.1   6.8e-33   4.1e-29       3     136 ..      38     171 ..      36     179 .. 0.93

  Alignments for each domain:
  == domain 1  score: 101.4 bits;  conditional E-value: 6.8e-33
  CSN8_PSD8_EIF3K   3 kaelytniLlkaLtqndladfrlllkrlpaaiqqsdeeiqklltLetlLeeanyakfwstlksddl.sadltadvagleelvReeiaklvgkaY 95 
                      ++++y+ +Ll +L+++dl++ r+l+kr+p++ +++   ++ ++++++ L+++ny+  ++++ + ++ s++l++ +  + ++ R++++ l++kaY
       EFC38648.1  38 STLFYGSFLLGYLINDDLNNCRFLWKRMPNDAKKD-DDLKGIWEVAKQLWNRNYEGAYQAISQLSPaSPQLKELINYFVDQLRQRTLLLISKAY 130
                      6789******************************8.*************************99866266************************* PP

  CSN8_PSD8_EIF3K  96 esIsadvlaelLglssdeelekfvkevgWeldaatvivpfn 136
                       +I++++l++ Lg+++ + l ++v   +W++d+at++++ +
       EFC38648.1 131 ANINTNDLMKCLGINDVNVLNQIVSPLNWTFDSATNVYIPQ 171
                      ***************999999999999*********99944 PP

>> SAC3_GANP  SAC3/GANP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   2.6e-07    0.0016     186     291 ..      59     161 ..       8     163 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.6e-07
                 HHHHHHCTS-HHHHTSHHHHHHHHHHHHH--TTHHHHHHHHT...TS-HHHHHHHGGGHHHHHHHHHHHHHHHS-TT---EEHHHHHHHTT-SSHHHHH CS
   SAC3_GANP 186 dilrevqelpseilkspevqlalklvaalqennyvrffklvk...evsylqacllerhfnevRrkalkalsraykskskkvpleeLaelLlfddeeeae 281
                 ++l   +++p++  k+++++   ++++ l ++ny    + ++    +s     l++ +++++R++ l  +s+ay     ++++++L++ L+++d + ++
  EFC38648.1  59 RFL--WKRMPNDAKKDDDLKGIWEVAKQLWNRNYEGAYQAISqlsPASPQLKELINYFVDQLRQRTLLLISKAY----ANINTNDLMKCLGINDVNVLN 151
                 333..4589************************99888888844433444566788999***************....789***************999 PP

                 HHHHHTT--E CS
   SAC3_GANP 282 efceayglev 291
                 ++++ ++ ++
  EFC38648.1 152 QIVSPLNWTF 161
                 9998887766 PP

>> PCI  PCI domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   2.1e-06     0.013       8      78 ..      83     150 ..      62     158 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 2.1e-06
                 HHHHHTSHHHHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHHHHCESEEEHHHHHHHHTSSHHHHH CS
         PCI   8 kalrsgnlsgfseelkdleeelladdglaqllesLekkvrerllrqvskiyssislerlaklldlsvdevE 78 
                 k+l ++n++g+ ++  +l   + a ++l +l++++++++r+r+l  +sk y +i   +l k l++++ +v 
  EFC38648.1  83 KQLWNRNYEGAYQAISQL---SPASPQLKELINYFVDQLRQRTLLLISKAYANINTNDLMKCLGINDVNVL 150
                 556667777777777777...677899*************************************9985554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       619  (0.0345251); expected 358.6 (0.02)
Passed bias filter:                      536  (0.0298957); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 1094.54
//
Query:       EFC38649.1  [L=332]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-31  110.2   0.0    1.4e-31  109.9   0.0    1.1  1  Pkinase         Protein kinase domain
    2.9e-15   56.3   0.0    3.4e-15   56.0   0.0    1.1  1  Pkinase_Tyr     Protein tyrosine kinase
    8.8e-08   31.3   0.0    1.1e-07   31.0   0.0    1.2  1  Pkinase_fungal  Fungal protein kinase
     0.0013   18.7   0.0       0.01   15.8   0.0    2.2  2  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
       0.13   11.6   0.0       0.21   10.9   0.0    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.9   0.0   3.9e-35   1.4e-31       3     245 ..      25     282 ..      23     289 .. 0.83

  Alignments for each domain:
  == domain 1  score: 109.9 bits;  conditional E-value: 3.9e-35
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH..HHSS--HH CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfeekdelylvleyveggeladlle..rkgslsee 98 
                  + klG+G+fG+ y av+ ++g+ vA+K+ k +++k      +  E+  lkk++ +p++vr++++ +++d+ +lv+e +  ++ladl +   +g++s++
  EFC38649.1  25 IQGKLGQGAFGETYAAVDLHSGEDVAIKVEKLDNKKIV----LKLEVIALKKVQaCPYVVRYIHSGRQDDYNFLVMERLG-ESLADLRKrtPRGAFSMS 118
                 6789************************9888876654....558*********************************98.67999999777899**** PP

                 HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE...EEE-SGTTSEESSSSCS.......BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHH CS
     Pkinase  99 eakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDFGlakelesssk.......ltsfvgtseYlAPEvlkeneyskkvDvWslGvi 186
                 ++ ++  q++e+le +H+ g iHrD+Kp+N+ +  +k +     ++DFGla++++  s           f gt +Y +    +++e ++  D+Ws+  +
  EFC38649.1 119 TTLRLGIQMIESLEGVHKLGYIHRDVKPSNFVMGrSKPKrgrTYLIDFGLARKYKLPSGeirpprrNAGFRGTARYASINSHHSKELGRRDDLWSVFYV 217
                 *******************************998443336669************998899***99999***********99***************** PP

                 HHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHHTTS...-HHHHHHHHHHT CS
     Pkinase 187 lyelltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasei...seeakdllkkll 245
                 l+e+  g+ p+++ k+ke +  el++ ++ +++++    e+++ +++ +++   +e   d+lk+ll
  EFC38649.1 218 LVEFALGSLPWRKIKDKE-HIGELKERFTNAELVKdlpnEYQLFMEHLQKLgyaDEPDYDFLKSLL 282
                 ************777766.55555554444444332333333333333333666666666666665 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.0   0.0   9.6e-19   3.4e-15       3     240 ..      25     263 ..      23     282 .. 0.83

  Alignments for each domain:
  == domain 1  score: 56.0 bits;  conditional E-value: 9.6e-19
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTT CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvctkeepllivteyvkgGdLlkfLrkkekek 99 
                  ++ klG+GafG+ + +       ++ ++Va+K+ k ++++     l  e+  +kk+   p +v+++    +++  ++v+e + + +L +  +++ + +
   EFC38649.1  25 IQGKLGQGAFGETYAAVDL----HSGEDVAIKVEKLDNKK---IVLKLEVIALKKVqACPYVVRYIHSGRQDDYNFLVMERLGE-SLADLRKRTPRGA 114
                  6789**********99887....78999****98655444...46777********999*********************8754.677766666789* PP

                  SBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEE....EETTSSTSGGGGS-HHHHHHSEEEHHHHHH CS
  Pkinase_Tyr 100 ltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddey....vkkeeaklpvkWmapEslkekkftsksDvW 189
                  ++++++l++ +q+ + +e +++  ++Hrd+   N ++ +    +    + DfGLar+ +  +      +++ + +   ++ ++ s ++k++  + D W
   EFC38649.1 115 FSMSTTLRLGIQMIESLEGVHKLGYIHRDVKPSNFVMGRskpkRGRTYLIDFGLARKYKLPSGEirppRRNAGFRGTARYASINSHHSKELGRRDDLW 212
                  ************************************9986665668999********96555444666788888999********************* PP

                  HHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEE.S-BBTTSBHHHHHHHHH CS
  Pkinase_Tyr 190 sfGvllwEiftlgespypglkneevleklkegkr.lekpekcpeelyelmkk 240
                  s   +l E + lg+ p++++k++e +  lke+    e  ++ p+e + +m++
   EFC38649.1 213 SVFYVLVEFA-LGSLPWRKIKDKEHIGELKERFTnAELVKDLPNEYQLFMEH 263
                  ********66.5********99999999966544155566666666666655 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.0   3.2e-11   1.1e-07     313     405 ..     125     219 ..      64     222 .. 0.85

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 3.2e-11
  Pkinase_fungal 313 rDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesga....rertGTleFmaievlkgeeHsyrhDLESffyv 403
                     ++ I+ ++  + k g++HrD+   N ++    k ++ +  LiD+ la +++ +s e  +        GT+ + +i+  + +e   r+DL S+fyv
      EFC38649.1 125 IQMIESLEGVH-KLGYIHRDVKPSNFVMG-RSKPKRGRTYLIDFGLARKYKLPSGEIRPprrnAGFRGTARYASINSHHSKELGRRDDLWSVFYV 217
                     56788888888.*****************.556678899************9998886554446678**********9999999*********** PP

  Pkinase_fungal 404 ll 405
                     l+
      EFC38649.1 218 LV 219
                     97 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   2.9e-06      0.01     125     197 ..      79     170 ..      74     172 .. 0.77
   2 ?   -2.3   0.0      0.96   3.4e+03      70      94 ..     215     240 ..     199     298 .. 0.66

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.9e-06
                 HHHHHHCHHHCCCGCCTCCHHHHHHHHHHHHHHHH--S....................SS-EEEE-SS-SGGGEEEC.....TTEEEEE---TT-E CS
         APH 125 llrqlesatarllaselldlleeleeqvlaalaallpg....................elptvllHgDlhpgNllvd...pddgrvtGviDfedag 197
                 + r+++s   r+++ ++l   e+l e +++ ++++ +g                      + + +H+D +p N+++    p  gr t++iDf++a+
  EFC38649.1  79 VVRYIHSG--RQDDYNFLV-MERLGESLADLRKRTPRGafsmsttlrlgiqmieslegVHKLGYIHRDVKPSNFVMGrskPKRGR-TYLIDFGLAR 170
                 55666666..666666666.7777775555555555558888888888888888888778899***************9988899.7******996 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.96
                 EEEEEE----EE-SS.HHHHHHHHHH CS
         APH  70 lfalieyvpgrsllr.klsaaqlpel 94 
                  ++l+e+  g  ++r   + ++++el
  EFC38649.1 215 FYVLVEFALGSLPWRkIKDKEHIGEL 240
                 56667777777777753333333333 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   5.9e-05      0.21      93     169 ..      93     169 ..      64     177 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 5.9e-05
         Kdo  93 lllterlegaqdLedllakwae..laeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldka 169
                 +l++erl   ++L+dl ++  +  ++ + + +l  +     +  h++g  H+d+ + n+ +   + +  + +liD+  a
  EFC38649.1  93 FLVMERLG--ESLADLRKRTPRgaFSMSTTLRLGIQMIESLEGVHKLGYIHRDVKPSNFVMGRSKPKRGRTYLIDFGLA 169
                 78888884..3444444431112233333333333333455667********************9999********765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (332 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       535  (0.0298399); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.30s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 1890.87
//
Query:       EFC38650.1  [L=304]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-56  190.8   3.9    4.7e-56  190.4   3.9    1.1  1  DUF410    Protein of unknown function (DUF410)
  ------ inclusion threshold ------
      0.014   15.3   0.3      0.058   13.3   0.0    2.1  3  DUF5076   Domain of unknown function (DUF5076)
      0.031   14.4   0.5      0.069   13.3   0.5    1.6  1  Skp1_POZ  Skp1 family, tetramerisation domain


Domain annotation for each model (and alignments):
>> DUF410  Protein of unknown function (DUF410)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  190.4   3.9   7.9e-60   4.7e-56       1     255 []      32     298 ..      32     298 .. 0.92

  Alignments for each domain:
  == domain 1  score: 190.4 bits;  conditional E-value: 7.9e-60
      DUF410   1 qkkydeAidllyqgalellkakqygsgaDLalllvevyekaevevdee...skdrl..iellskf...........paeep.erkkfikaaikwSakkg 82 
                 q+kyd+++++l +g++++ + kq++  +DLa +++  ++k +++++++     d++  i+l++++           p+e+  ++ +f++++++wSa+++
  EFC38650.1  32 QEKYDKCAQILLSGLNKMHQFKQVALLIDLAKYMLSLFTKLNASTTHTftiKEDKItaIDLIRHIvesyhqleditPKEDIqRMISFLDKVVTWSAEHQ 130
                 689******************************************9997764466666777775555555556555444437999************** PP

      DUF410  83 e....kkaGdpeLhhllaklllkegeleeAerhlllgtddsaeelakllvewaeegeeseadlfiaRavLqylllgnvkaAnklldeflkkleskessl 177
                      +++G+p +h  l+kl +k g  ee+++++l +  +s++e+a+++ ew ++ge++e+dlfi+RavLq+l l+++++A+++++ + +k+e+ +s  
  EFC38650.1 131 VpkisDSHGEPFIHMELGKLHFKLGANEESNKNFLKS--NSPDEFAEMISEWIKKGEDGEHDLFITRAVLQLLQLKKLEMAKRVFELLQQKTEKLSS-- 225
                 66788********************************..8888*************************************************99998.. PP

      DUF410 178 ltervfplpllnFlqlllltiqrkskelFkkLkekYkpslkr.dpslke.ylekIgelyFgikpprqqsnglqdmmssLl 255
                        +pll+F+++l+++i++++ el+++++++Y+++l+r d+s+k+ yl+kIg++yFg++++++q++gl++m++sL+
  EFC38650.1 226 -------TPLLHFVKFLIISIEKGNLELYHHINQSYATELTRrDASFKDvYLDKIGSIYFGLQKSKPQNQGLGSMINSLF 298
                 .......8******************************999989999998*****************************9 PP

>> DUF5076  Domain of unknown function (DUF5076)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.99   5.9e+03      44      52 ..      56      64 ..      47      79 .. 0.77
   2 ?   13.3   0.0   9.7e-06     0.058      47      77 ..      90     120 ..      87     125 .. 0.90
   3 ?   -3.2   0.0       1.4   8.1e+03      49      60 ..     246     257 ..     244     263 .. 0.68

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.99
                HHHHHHHHH CS
     DUF5076 44 ilLadlarh 52
                +lL+dla+ 
  EFC38650.1 56 ALLIDLAKY 64
                589999875 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 9.7e-06
                 HHHHHHHHHHHHHTSSS-HHHHHHHHHHHHH CS
     DUF5076  47 adlarhiaralaeedelseeealerilegfe 77 
                 +dl+rhi++++++ ++++++e+++r++  ++
  EFC38650.1  90 IDLIRHIVESYHQLEDITPKEDIQRMISFLD 120
                 7************************997665 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHT CS
     DUF5076  49 larhiaralaee 60 
                 l +hi +++a e
  EFC38650.1 246 LYHHINQSYATE 257
                 677888887765 PP

>> Skp1_POZ  Skp1 family, tetramerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.5   1.2e-05     0.069       4      62 ..      71     130 ..      69     131 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.2e-05
                 EEEETTSCEEEEEHHHHTTSHHHHHHHHCTCCCGTTCEEETTS-HHH..HHHHHHHHHHCH CS
    Skp1_POZ   4 vLqSsDgesfeveeavakkSktikhmiedlgdddkpriplpnvtski..LekvieYckhhk 62 
                 +L  s  + f + e+ +    +i h++e   + ++ + p++ ++  i  L kv+++ + h+
  EFC38650.1  71 KLNASTTHTFTIKEDKITAIDLIRHIVESYHQLED-ITPKEDIQRMIsfLDKVVTWSAEHQ 130
                 78888899*************************88.99******99998*******99997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       902  (0.0503096); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2075.86
//
Query:       EFC38651.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.029   14.0   0.0      0.041   13.4   0.0    1.5  1  FAM221    Protein FAM221A/B


Domain annotation for each model (and alignments):
>> FAM221  Protein FAM221A/B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   2.3e-06     0.041       1      35 [.      20      54 ..      20     123 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.3e-06
      FAM221  1 ykrivgdddggklfteeeyeeykkkvlplrlknRl 35
                y+ ivgd dgg l+ e eye+++k+ + +r +  l
  EFC38651.1 20 YRMIVGDRDGGVLLPEAEYEKLRKEFYAKREEHNL 54
                789**********************9988765544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       936  (0.0522059); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1329.67
//
Query:       EFC38652.1  [L=217]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.017   15.3   1.4      0.017   15.3   1.4    3.1  3  JIP_LZII        JNK-interacting protein  leucine zipper II
      0.048   14.1   4.2      0.048   14.1   4.2    3.7  3  ZapB            Cell division protein ZapB
        2.9    7.9  14.1        4.4    7.4   1.0    3.2  3  Ribosomal_L29   Ribosomal L29 protein
        5.2    7.3   7.3         23    5.2   0.4    2.5  2  CobA_CobO_BtuR  ATP:corrinoid adenosyltransferase BtuR/CobO/C


Domain annotation for each model (and alignments):
>> JIP_LZII  JNK-interacting protein  leucine zipper II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   2.5       0.3   1.4e+03      37      62 ..      17      42 ..       6      51 .. 0.73
   2 ?   -3.4   7.2       2.6   1.2e+04      23      61 ..      21      66 ..      16      79 .. 0.46
   3 ?   15.3   1.4   3.8e-06     0.017       3      42 ..     167     206 ..     165     216 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.3
    JIP_LZII 37 eLtsereiLreEleslqkakerlesr 62
                eL++  +iL++E  + ++++erl + 
  EFC38652.1 17 ELKKKLKILKKEYLKQKAELERLAQI 42
                67788888888888888888887664 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.6
    JIP_LZII 23 aLnvvkddLIarvdeLt.......sereiLreEleslqkakerles 61
                +L + k++ +++  eL        +++e L++   +++k k+++e+
  EFC38652.1 21 KLKILKKEYLKQKAELErlaqialCQQEELKQKDYQIKKYKQQCEE 66
                4444444444443333211111124555555555556666665555 PP

  == domain 3  score: 15.3 bits;  conditional E-value: 3.8e-06
    JIP_LZII   3 mgkevenLikENteLletknaLnvvkddLIarvdeLtser 42 
                 +++e+  L +EN  L+e k +Ln+ k +L + v +L++++
  EFC38652.1 167 LKQEIAALREENFTLREEKHKLNIEKVHLYELVHDLNQNY 206
                 6789**************************9999998765 PP

>> ZapB  Cell division protein ZapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   2.6      0.27   1.2e+03      39      64 ..      13      38 ..       4      43 .. 0.48
   2 ?   -3.8  16.9         4   1.8e+04       8      59 ..      35      86 ..      32     124 .. 0.89
   3 ?   14.1   4.2   1.1e-05     0.048      18      46 ..     162     193 ..     159     215 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.27
        ZapB 39 eenreleeeneqlkeereawqerlkk 64
                +   el+++++ lk+e  ++++ l+ 
  EFC38652.1 13 QYDPELKKKLKILKKEYLKQKAELER 38
                44444444444444444444444433 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 4
        ZapB  8 qLEskiqkaidtitlLqmeieeLkeeneelkeenreleeeneqlkeereawq 59
                +LE   q a+ + ++L+++ ++ k+ +++ +e+  +l+e  +ql+ ere  +
  EFC38652.1 35 ELERLAQIALCQQEELKQKDYQIKKYKQQCEEQSIKLSEYESQLQIERELCE 86
                677777888889999******************************9998665 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 1.1e-05
        ZapB  18 dtitlLqmeieeLkeeneelkeenrele...e 46 
                 +ti++L++ei++L+een +l ee+ +l+    
  EFC38652.1 162 ETISSLKQEIAALREENFTLREEKHKLNiekV 193
                 79*********************999985440 PP

>> Ribosomal_L29  Ribosomal L29 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   2.8    0.0011       4.9       8      26 ..      15      33 ..      12      44 .. 0.88
   2 ?   -1.8   0.1       0.7   3.2e+03       9      19 ..      48      61 ..      40      78 .. 0.68
   3 ?    7.4   1.0   0.00098       4.4       9      36 ..     165     192 ..     160     199 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0011
                   HHHHHHHHHHHHHHHHHHH CS
  Ribosomal_L29  8 deeLkeklkelkkeLfnLr 26
                   d eLk+klk lkke+++ +
     EFC38652.1 15 DPELKKKLKILKKEYLKQK 33
                   68*************9977 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.7
                   HHHHH...HHHHHH CS
  Ribosomal_L29  9 eeLke...klkelk 19
                   eeLk+   ++k+ k
     EFC38652.1 48 EELKQkdyQIKKYK 61
                   56666444444444 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.00098
                    HHHHHHHHHHHHHHHHHHHHHHHTSSS- CS
  Ribosomal_L29   9 eeLkeklkelkkeLfnLrfqkatgqlen 36 
                      Lk++++ l++e f+Lr  k    +e+
     EFC38652.1 165 SSLKQEIAALREENFTLREEKHKLNIEK 192
                    679***************8887555555 PP

>> CobA_CobO_BtuR  ATP:corrinoid adenosyltransferase BtuR/CobO/CobP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   1.7    0.0063        28      40     107 ..      58     132 ..      18     146 .. 0.65
   2 ?    5.2   0.4    0.0052        23      37      77 ..     150     189 ..     145     209 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0063
  CobA_CobO_BtuR  40 KgekesgElaalkkl....eielerlgkegfvkmeeeekeedaa...aakealekakealaseeydlvvlDEiny 107
                     K+ k+  E++++k      ++++er   eg ++m+++++ ++++   + ++  ek ++ l++++++l++lDE ++
      EFC38652.1  58 KKYKQQCEEQSIKLSeyesQLQIERELCEGAIRMKKSQQGTATNvavNNNQEKEKSNQPLSDNDLSLLLLDEGLT 132
                     442345555555544444433443333345554444333333330003344555666668889999*****9765 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0052
  CobA_CobO_BtuR  37 qFlKgekesgElaalkkleielerlgkegfvkmeeeekeed 77 
                      F+ +++e+ E++++++l+ e+  l++e+f+  +ee+++ +
      EFC38652.1 150 TFMLNTDEYQEEETISSLKQEIAALREENFT-LREEKHKLN 189
                     68888789***********************.555444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2441  (0.136148); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 1429.04
//
Query:       EFC38653.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.1e-20   74.3   1.3    1.5e-20   73.9   1.3    1.2  1  Laminin_G_3  Concanavalin A-like lectin/glucanases superfamil
    5.8e-07   30.1   0.0      1e-06   29.3   0.0    1.4  1  Laminin_G_2  Laminin G domain
  ------ inclusion threshold ------
      0.038   14.2   0.0      0.071   13.3   0.0    1.4  1  Laminin_G_1  Laminin G domain


Domain annotation for each model (and alignments):
>> Laminin_G_3  Concanavalin A-like lectin/glucanases superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.9   1.3   2.6e-24   1.5e-20       7     152 .]      96     245 ..      89     245 .. 0.81

  Alignments for each domain:
  == domain 1  score: 73.9 bits;  conditional E-value: 2.6e-24
  Laminin_G_3   7 vtlpdasl.p.tssfTvsaWvkpdslpsaaqiiis.sssdg..rgfelg.ldgsgrlrfsvnagngaeesvtsgasvpageWtHvavtydggtlrlYv 98 
                   +++++++ +  ++ ++s+W++  +++++  ++ +  s+    ++ +   l++s++l+f+++++ + + ++ s++++ ++eW+H+av+  ++ + +Y+
   EFC38653.1  96 FNTNSPTWvTfGTGKSLSLWLRKLTNTDSGVVWSFlMSQPPlfQHMGSNgLASSDNLEFYWKTSSTLPIRFYSSSKLLDNEWHHLAVVCKATGVDIYI 193
                  4555544435567789***********9988888765655555333333468888*********99999***************************** PP

  Laminin_G_3  99 NGvevgsatltggllsatsgplviGrdp.ggddpfdGlidevriynralsaaeIa 152
                  +Gv+++s++ t ++   ts+ + +G+ +  ++ +f G +de+r++n +l+aa+I+
   EFC38653.1 194 DGVLDNSSSSTFDPV--TSN-IKFGGLQgINSAFFSGHMDEIRMFNVELTAAQIQ 245
                  ********9888866..455.55666662479*********************97 PP

>> Laminin_G_2  Laminin G domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.0   1.7e-10     1e-06      29     123 ..     151     234 ..     133     237 .. 0.89

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 1.7e-10
                  EEEEEEESSS-EEEEE-SSSS-ESSSSEEEEEEECTTEEEEEECTS--CCCE-CSS.......S.EEES--TTHHHHCCTTTS-B-CEEEEEEEE CS
  Laminin_G_2  29 klvltynlgsgdtellssgkklndgewHsveverkgknltlsvDggetseanepgesqgldleeslylGGlepeepetaspvtegFvGcirdlrl 123
                  +l++ ++++s+    ++s++kl d+ewH++ v  k + + + +Dg   +++ ++++      ++++ +GGl       +  +++ F G+++++r+
   EFC38653.1 151 NLEFYWKTSSTLPIRFYSSSKLLDNEWHHLAVVCKATGVDIYIDGVLDNSSSSTFDPV----TSNIKFGGL-------QGINSAFFSGHMDEIRM 234
                  577777777777777888*****************************99999998876....6********.......9**************97 PP

>> Laminin_G_1  Laminin G domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.2e-05     0.071      30     100 ..     151     217 ..     149     232 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.2e-05
                  EEEEEEESSS-.EEEEEEEEETTSSS-EEEEEEEETTEEEEEETTSC-EEEES-TT-SSSEEECSEEEESSS CS
  Laminin_G_1  30 rlevsldlgsg.aavvvsgqklndGkwhkvevernkrsgtlsvdgeervtgesplgatttlnvnkklyvGGl 100
                  +le+ ++++s+ ++   s++kl d++wh++ v+ + + + + +dg  + + +s  ++ t      ++ +GGl
   EFC38653.1 151 NLEFYWKTSSTlPIRFYSSSKLLDNEWHHLAVVCKATGVDIYIDGVLDNSSSSTFDPVT-----SNIKFGGL 217
                  68999******9999999999************************99944444433333.....22444554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       498  (0.0277762); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1585.89
//
Query:       EFC38654.1  [L=434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.4   0.5       0.99    9.4   0.2    2.3  2  DUF5348   Domain of unknown function (DUF5348)
        2.2    8.6   5.8        5.2    7.4   5.8    1.6  1  PET117    PET assembly of cytochrome c oxidase, mitochondrial


Domain annotation for each model (and alignments):
>> DUF5348  Domain of unknown function (DUF5348)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.2   0.00011      0.99       2      51 ..      94     144 ..      93     157 .. 0.86
   2 ?    0.3   0.0     0.073   6.6e+02      35      54 ..     191     212 ..     170     222 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00011
     DUF5348   2 tLvydsegrryvvrfgdgeey.gL.hcGeslevlvedeWvptriEmdngewY 51 
                 +L ydse+++   + + ++++ +L ++Ge+l ++ + +  +t+++++  ew 
  EFC38654.1  94 ILIYDSESGKLLRTIKLRHYLfDLdSSGECLYIYSDRRMRKTKLDLSS-EWK 144
                 6999*****998877999999999568******************984.886 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.073
     DUF5348  35 edeWvptriEmdnge..wYlvg 54 
                 +++W +t+i +d++e   Yl g
  EFC38654.1 191 SKKWRCTKISYDEKEgkIYLSG 212
                 34999****9996554466655 PP

>> PET117  PET assembly of cytochrome c oxidase, mitochondrial
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   5.8   0.00058       5.2      28      68 ..     353     390 ..     350     392 .. 0.91

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00058
      PET117  28 realrqGvirDaerqaeKerkrkenkaeleeqkelrkkyek 68 
                 + +l+  +++D+ + + +   ++e  a+ +eq+++++++e+
  EFC38654.1 353 KSKLHSDPLKDDFKERLR---MEEELAKKKEQEKKKEELER 390
                 679***************...9999999999***9999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1387  (0.0773607); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.26s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 2709.62
//
Query:       EFC38655.1  [L=490]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (490 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1928  (0.107535); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 2975.43
//
Query:       EFC38656.1  [L=304]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.5e-17   61.9   0.3    1.1e-16   61.0   0.3    1.5  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.0   0.3     6e-21   1.1e-16       3      98 ..      11     112 ..       9     118 .. 0.87

  Alignments for each domain:
  == domain 1  score: 61.0 bits;  conditional E-value: 6e-21
                 EEEEEEEEESSSSSSTTSSCEEEEEEEE..ECEEEEEE-SCSSSSSSEEEEEEEEEESC..HTTSEEEEEEEEECSSSTEEEEEEEEEEGHH..HHTTH CS
          C2   3 levtvieAknLpnkdkkgssdpyvkvsl..dgkqkakTrviknslnPvWnekftfevae..leeakLeveVfdndrlskddfiGkveiplst..llsge 95 
                 +++tv+++++L   d +g sdpyv +     +++ +kT v +++lnP+Wn +f    +e  +++ kL++eV+d+d  ++ddf+G +ei+l+   l+ ++
  EFC38656.1  11 IKFTVVRGEKLMVGDSNGLSDPYVLIIDqsTKQTLHKTVVDRKTLNPRWNSTFWKRYTEetPKNLKLKIEVYDWDDDKDDDFLGWFEIELDPnvLNPDQ 109
                 6799*******************988777788888999988**************99999****************89999*********997655555 PP

                 HHH CS
          C2  96 eae 98 
                  +e
  EFC38656.1 110 TYE 112
                 444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       581  (0.0324056); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1722.00
//
Query:       EFC38657.1  [L=459]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0025   17.9   2.3     0.0052   16.9   2.3    1.5  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   2.3   2.9e-07    0.0052      16      39 ..       9      31 ..       6      32 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 2.9e-07
                SSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus 16 kkPaCsnCkklnleCtfysesskr 39
                + P+Cs+C++++ +C+ y+ ++kr
  EFC38657.1  9 QLPTCSRCATKGITCE-YKTPKKR 31
                78**************.7777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (459 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       782  (0.0436165); expected 358.6 (0.02)
Passed bias filter:                      435  (0.0242624); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 2888.84
//
Query:       EFC38658.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.4e-28   98.0   0.0    1.1e-27   96.7   0.0    1.6  2  CRAL_TRIO    CRAL/TRIO domain
    6.1e-07   29.5   0.8    6.1e-07   29.5   0.8    2.1  2  CRAL_TRIO_N  CRAL/TRIO, N-terminal domain
  ------ inclusion threshold ------
       0.05   13.8   0.0       0.18   12.0   0.0    1.9  2  CRAL_TRIO_2  Divergent CRAL/TRIO domain


Domain annotation for each model (and alignments):
>> CRAL_TRIO  CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.73   4.4e+03      77      94 ..      44      61 ..      27      63 .. 0.77
   2 !   96.7   0.0   1.8e-31   1.1e-27       7     159 .]     127     276 ..     122     276 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.73
   CRAL_TRIO 77 mlwkpisllkkilkilqd 94
                + +k++++lkk+ ++++d
  EFC38658.1 44 LTDKQLEILKKFTQMFED 61
                445669999999999986 PP

  == domain 2  score: 96.7 bits;  conditional E-value: 1.8e-31
   CRAL_TRIO   7 gkvgihgrDkegrpvlylrlgrfdpkklsleelvralvlvlerllkeleedgqvegvtvviDlkglslskmlwkpisllkkilkilqdnyperlgkili 105
                  k++i g Dk grp++yl++gr  +++   ++ v +lv+ l ++   + +  +  ++t ++D++ ++ +  +  p+ ++k+ ++il+ ++perlg +l+
  EFC38658.1 127 AKTYIKGHDKAGRPIIYLHAGRDFTNDP--ATGVSLLVYNLIAASYRMGP--NGSQMTWICDFSSYTTKSAP--PLAVCKQAVEILSSHFPERLGLCLM 219
                 689******************7666643..47999999999999988888..8899***********66555..6************************ PP

   CRAL_TRIO 106 vnaPklfkfafklvkpfldektreKikfvspsntea...tlekyidpeqlpkelGGt 159
                 v aPk+f ++fkl++p+++++t++Ki+f+++++ ++    +e ++d +ql+k++GG+
  EFC38658.1 220 VFAPKVFYWFFKLISPLIPPVTKQKIQFCKGTKQKDmraFFEPFVDMSQLEKKYGGD 276
                 *****************************988775577689999************6 PP

>> CRAL_TRIO_N  CRAL/TRIO, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.5   0.8     1e-10   6.1e-07       2      53 ..      52     100 ..      51     101 .. 0.81
   2 ?   -1.3   0.7      0.45   2.7e+03      18      27 ..     282     292 ..     263     335 .. 0.71

  Alignments for each domain:
  == domain 1  score: 29.5 bits;  conditional E-value: 1e-10
  CRAL_TRIO_N   2 ydellahlqeseyklteeekfWltredhddaclLRfLRArkwdvekAikrLe 53 
                  ++++ + +++   klt+ ++ +     hd+ c++R+L+Ar+wd+ +A k L+
   EFC38658.1  52 LKKFTQMFEDDRSKLTQLQQYYC---FHDRFCFVRYLKARDWDIPNATKLLK 100
                  67888899988888666655552...55579******************997 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.45
  CRAL_TRIO_N  18 eeekfW.ltre 27 
                   ++++W +  e
   EFC38658.1 282 NHKEMWaHEIE 292
                  46777766555 PP

>> CRAL_TRIO_2  Divergent CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.38   2.3e+03      55      84 ..      48      79 ..      21     118 .. 0.66
   2 ?   12.0   0.0     3e-05      0.18      30     113 ..     170     252 ..     138     289 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.38
  CRAL_TRIO_2 55 slswlkkvystlprrykk..nlkklyivhpst 84
                 +l  lkk+ ++++    k  +l+  y +h  +
   EFC38658.1 48 QLEILKKFTQMFEDDRSKltQLQQYYCFHDRF 79
                 55666666666654433311466777766664 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 3e-05
  CRAL_TRIO_2  30 ladkivgkeyvlVyfhtglssenkpslswlkkvystlprrykknlkklyivhpstfvktllktvlsafvsskfrkkveyvsrle 113
                    +   g++++ +++ +  + ++ p l ++k++ ++l+ +++++l    +v +   +  ++  + s++  +  ++k+ ++   +
   EFC38658.1 170 YRMGPNGSQMTWICDFSSYTTKSAPPLAVCKQAVEILSSHFPERLGLCLMVFAPKVFYWFF-KLISPLIPPVTKQKIQFCKGTK 252
                  3333678899************************************999988886666666.3444444455567777776544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       692  (0.0385967); expected 358.6 (0.02)
Passed bias filter:                      560  (0.0312343); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1925.57
//
Query:       EFC38659.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-11   44.1  14.2      5e-08   32.1   0.5    2.2  2  Aa_trans    Transmembrane amino acid transporter protein
  ------ inclusion threshold ------
       0.23   11.2   0.2       0.36   10.6   0.2    1.2  1  DUF1955     Domain of unknown function (DUF1955)


Domain annotation for each model (and alignments):
>> Aa_trans  Transmembrane amino acid transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.5   5.6e-12     5e-08       9      72 ..      71     139 ..      63     146 .. 0.79
   2 !   16.5   7.4     3e-07    0.0027     120     289 ..     274     466 ..     203     515 .. 0.72

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 5.6e-12
    Aa_trans   9 vlnlikaivGaGvLaLPyAfkqlGlivGlillllvallslytlllLvkcs.ktla....sgkrnksYgd 72 
                    +++ i G GvL++PyAf+++Gl++G+i ll+v+ll  + l+ +++++ ++++    +++++k+Y+ 
  EFC38659.1  71 YCYCVNYILGVGVLGIPYAFQKGGLLMGPIFLLIVTLLAGMVLVWILETLcRSVPffkeKEEQKKDYKM 139
                 567899****************************99999887776666541445577677777777765 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 3e-07
    Aa_trans 120 lllsnvyfilisaliiipLsli..pnlskLsyl.Sllalvsslyy..ivilvlvvaelvklelkgvseetv.......kkasklkglflaigiivFAft 206
                 ++    ++i ++al++ip++ +  ++ + ++++  ++  v+++++   ++++++v  +  +e++ +  ++        ++  ++ g+++ +++ ++A  
  EFC38659.1 274 CDALYKIYIGVFALFVIPMTCLnlTEQKIVQIFlTIFRYVALTLMvvTTLVSIFVDPYSRYEHNPHIAMERhgpytspTSLVSVLGFSTLLPVCIYAQI 372
                 5555667888999999998855113444444331233333333333356666666677777777666666589999988999999************** PP

    Aa_trans 207 ghavlleiqnelkdpskfkkmtkvlllsiilatvlyilvGlvGYltFGnevkgnillnlpkss..............ilivivnlllvlhlilsfpl 289
                  h+ ++ + + +++ ++ +   k+   ++i+++++y l+G v    +G++++    ln+  +               ++i ++ l+ ++ +i +fpl
  EFC38659.1 373 LHHSVPGLCEPVRNKKHLP---KIFTSTFITTFFIYSLLGIVLSIYYGDNIQPACSLNYVWYRggkpfgmrqpwwshVIIWTIALFPAVDVISAFPL 466
                 **************99988...9********************************999965545555666666544444555555556666666665 PP

>> DUF1955  Domain of unknown function (DUF1955)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.2     4e-05      0.36      35      81 ..     257     308 ..     245     325 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 4e-05
                 HHHTHHHHHHHH..H--HHHHHHHHHHHGGGS-G.GG-S-T..HHHHHHHHH CS
     DUF1955  35 keanWvicniid..aidcdylvevldsiGkifdl.skcqnl..krviecyvk 81 
                 +++nW+ cn+    + +cd+l+++   +   f +  +c nl  +++++ +++
  EFC38659.1 257 NNYNWFTCNVYTdgSSNCDALYKIYIGVFALFVIpMTCLNLteQKIVQIFLT 308
                 689*******8434789*******9999999998447999843456666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1318  (0.0735122); expected 358.6 (0.02)
Passed bias filter:                      671  (0.0374254); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.50
# Mc/sec: 3138.64
//
Query:       EFC38660.1  [L=201]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0014   18.0   0.0     0.0027   17.1   0.0    1.5  2  YmdB      YmdB-like protein
  ------ inclusion threshold ------
       0.57   10.6   3.8        2.5    8.6   3.8    2.1  1  FUN14     FUN14 family


Domain annotation for each model (and alignments):
>> YmdB  YmdB-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.0     3e-07    0.0027      45      92 ..      18      66 ..       4      94 .. 0.77
   2 ?   -3.4   0.0      0.54   4.8e+03      47      59 ..     145     157 ..     133     167 .. 0.71

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3e-07
        YmdB 45 tkkeaeellkagvdviTlGnhvwdkkeilelieeeerllrPa.Nypega 92
                   +++ +l+ag+d i l nhv  ++e+ ++ +++++++ P  N +  +
  EFC38660.1 18 AGGNYDAILDAGIDSIDLSNHVHLNRELEKASDDQKEIVYPTlNSEIAT 66
                556899**********************************952555444 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.54
        YmdB  47 keaeellkagvdv 59 
                 +++e l k+g+d+
  EFC38660.1 145 EQYEMLAKIGIDA 157
                 4566666666664 PP

>> FUN14  FUN14 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   3.8   0.00028       2.5       1      89 [.      88     198 ..      88     200 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00028
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...................xxxxxxxxxxxxxxxx.......... RF
       FUN14   1 igiGaviGlvtGfalkkvgKlaaiavGggllllqilasqgyikvnwdkiekdve...................elldrnkdgklgtede.......... 70 
                 ig+G++ G+++G +++  +++++ a++  lll  +  s    +   +  ++++                    +                         
  EFC38660.1  88 IGVGGMGGYMSGNVIRIGSRVVFGAIAAVLLLGTTFTSVSRTSLRKKTSTNKMVndleqyemlakigidaankQ--------------Lqninfreiiv 172
                 7899******************9999999999998888887777655555444434446655555544444331..............03344444555 PP

                 .......xxxxxxxxxxxxxxxxxxx RF
       FUN14  71 .......klltenlpfsagFlaGfll 89 
                        +++++n  ++ +Fl+Gf++
  EFC38660.1 173 hkwdqlkEYTKDNYALTSSFLLGFII 198
                 55656678888899999999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (201 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1038  (0.057895); expected 358.6 (0.02)
Passed bias filter:                      553  (0.0308439); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1165.63
//
Query:       EFC38661.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.1e-15   54.9   0.0    7.8e-15   54.5   0.0    1.4  1  RdRP      RNA dependent RNA polymerase


Domain annotation for each model (and alignments):
>> RdRP  RNA dependent RNA polymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.5   0.0   4.4e-19   7.8e-15     405     470 ..       2      67 ..       1     213 [. 0.73

  Alignments for each domain:
  == domain 1  score: 54.5 bits;  conditional E-value: 4.4e-19
        RdRP 405 qvvkavdvpelrhlkdviVFstkGdrslaselsGGDlDGDkywViwdpe.le.fapakpsneepadye 470
                 + ++av+   l hlkdv+VFs+ G+  ++s +sG DlDGD ++++wd e +e ++   ++ +ep++  
  EFC38661.1   2 RLFQAVKKDCLTHLKDVVVFSSLGPEFVPSLISGADLDGDHFYIFWDSElVEnIQCV-DE-KEPSSIL 67 
                 7899**889****************************************77766433.22.3444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       404  (0.0225333); expected 358.6 (0.02)
Passed bias filter:                      273  (0.0152267); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.54
# Mc/sec: 1577.93
//
Query:       EFC38662.1  [L=404]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-24   86.6   1.7    1.7e-22   80.0   1.7    2.3  1  ThrE         Putative threonine/serine exporter
     0.0028   17.8   5.0     0.0042   17.2   5.0    1.3  1  ECF_trnsprt  ECF transporter, substrate-specific component
  ------ inclusion threshold ------
        0.4   10.8   2.2       0.88    9.7   0.0    2.7  2  ETRAMP       Malarial early transcribed membrane protein (ETR
       0.68    9.3   7.8        1.1    8.6   7.8    1.3  1  TssN         Type VI secretion system, TssN


Domain annotation for each model (and alignments):
>> ThrE  Putative threonine/serine exporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.0   1.7   3.8e-26   1.7e-22       6     232 ..     122     398 ..     118     402 .. 0.77

  Alignments for each domain:
  == domain 1  score: 80.0 bits;  conditional E-value: 3.8e-26
        ThrE   6 lGeiLlesGaetyrvedtmkriaralgleevevfvtptsiivsvd........eeees...........ittvrr...............vrsrgvnle 70 
                 l  +L  +G +++r+e ++k++   + le++e+ +tp+s+ + ++        +   +                +                   +++l 
  EFC38662.1 122 LSYALGIYGVPSHRLEMHLKTLFDCFPLEKCEFRYTPSSLWFCFTpnfnlnrnD---EyeegdgivthnS----NaylskskfyvvkldeYDLEDMDLV 213
                 66688889**********************************995478774431...2344555533330....2566667778766665778889999 PP

        ThrE  71 klsevnelsreiaag...........eisleeaeerLdeIerskpryprwlvvlaaglaaaafallf.ggdwidflvaflagllggllrlllakrglns 157
                 kl+e+++l+ ei +               +++++ r+++I ++ +  +  +++++a l++a++ ++   g+w+++l+ +++g+ +g+l  + +k+  ++
  EFC38662.1 214 KLCELDQLASEIPELmavtennpeslSNLIDDLRGRIRTIISRYSFVRSAIRLFIANLISASMWVMYyDGSWMEMLCGLIVGIATGILVVIAEKYPSFN 312
                 *********9997754333233221112235558999999999999999**************99999************************9987666 PP

        ThrE 158 fvleavaaflasllallavsl...........glglnpdaiiigsillLvPGlpltnavrDllsgdlvsGlaRlveailialaiaf 232
                  v+ +++a++a+++a+l+  +           ++  ++  ++++++  L+P +++tn++ +l++++lvsG+ R+++a++++l ++f
  EFC38662.1 313 RVNPFISAIVAGTVASLTKVIfskmlteedrgKYPFSVFLVTLCALFGLLPHVSFTNGISELATKNLVSGSMRVFYAFVLILQVCF 398
                 666666666666666544443333355554433333479*******************************************9997 PP

>> ECF_trnsprt  ECF transporter, substrate-specific component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   5.0   9.3e-07    0.0042      50     123 ..     260     334 ..     255     398 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 9.3e-07
                  HHHHHHHHHHHHCHT-SSTTHHHH......HHHHHHHHCHHHHHHHHHHCCCHTTHHHHHHHHHHHHCCCCCHHHHHHHC CS
  ECF_trnsprt  50 ilgiitsvlkailtggtgalssfv......piaflsriligliagllykkgkkknlkeivvsfilagvlgtivatllvll 123
                  + ++i  +++ ++     + s+ v      ++ +l+++++g+++g+l  +  k+  ++ v +fi+a+v+gt++ +  v++
   EFC38662.1 260 VRSAIRLFIANLI-----SASMWVmyydgsWMEMLCGLIVGIATGILVVIAEKYPSFNRVNPFISAIVAGTVASLTKVIF 334
                  3344444445555.....3333333469*****************88888888888888************998876655 PP

>> ETRAMP  Malarial early transcribed membrane protein (ETRAMP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0    0.0002      0.88      32      78 ..      58     129 ..       9     134 .. 0.77
   2 ?   -1.8   1.0      0.74   3.3e+03       4      18 ..     384     398 ..     383     401 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0002
      ETRAMP  32 k.........................ekakkaikkiddkiekkkkkkKliiistiatalallvasalGlgiy 78 
                 +                           +k+++kk +d ++k++  kK++ is+   +  l + + ++lgiy
  EFC38662.1  58 TifselssfkppegehnlnpirsdfaIMKKQSFKKEEDYFTKQNEEKKPVQISLQEKVHGLFIDLSYALGIY 129
                 267777777777777777777777778899***********************9988888888888888877 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.74
      ETRAMP   4 tkvllffafLlavnl 18 
                 ++v++ f+++l v++
  EFC38662.1 384 MRVFYAFVLILQVCF 398
                 688999999998887 PP

>> TssN  Type VI secretion system, TssN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   7.8   0.00024       1.1      21     148 ..     272     402 ..     259     404 .] 0.72

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00024
        TssN  21 iakknkllkkkkliiyiLlaglvlalpgllgflknefvpygyillqilylllGilhly..lllkkffkelkekkilfeilltlivillglvlfvlvfnl 117
                 i++ + +++     + +L+ ++v   +g+l  +  ++   + +   i +++ G++     +++ k+  e +  k+ f+++l+ +++l+gl+++v   n 
  EFC38662.1 272 ISASMWVMYYDGSWMEMLCGLIVGIATGILVVIAEKYPSFNRVNPFISAIVAGTVASLtkVIFSKMLTEEDRGKYPFSVFLVTLCALFGLLPHVSFTNG 370
                 555555555555556667777777778888888888888888888888888888875411244444444455559************************ PP

        TssN 118 lselqygvwaatsllvf.iipllflktykall 148
                 +sel  + ++++s+ vf  ++l++  +++++ 
  EFC38662.1 371 ISELATKNLVSGSMRVFyAFVLILQVCFNSFA 402
                 *****777777777555167777888898886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (404 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       984  (0.0548832); expected 358.6 (0.02)
Passed bias filter:                      639  (0.0356406); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 2461.34
//
Query:       EFC38663.1  [L=442]
Description: histone deacetylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.7e-71  239.3   0.7    7.3e-70  235.9   0.0    2.1  2  Hist_deacetyl  Histone deacetylase domain
  ------ inclusion threshold ------
      0.041   13.3   0.0       0.12   11.8   0.0    1.7  1  DUF1256        Protein of unknown function (DUF1256)


Domain annotation for each model (and alignments):
>> Hist_deacetyl  Histone deacetylase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.1     0.016   1.5e+02      37      62 ..       9      34 ..       2      49 .. 0.79
   2 !  235.9   0.0   8.1e-74   7.3e-70       5     303 ..      52     373 ..      48     377 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.016
                   HHHTTTS-HHHHHHHHCHHHHCHHT. CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 37 eellkvHskeYlelleslsnelkkke 62
                   + ++ vHs++Yl++ ++l  + +++e
     EFC38663.1  9 HTIKYVHSERYLNACSKLPAYNRHSE 34
                   56889*********999988776665 PP

  == domain 2  score: 235.9 bits;  conditional E-value: 8.1e-74
                    THHHHHHHHHHHHT.THHHHCCE.EE-----HHHHTTTS-HHHHHHHHCHHHHCHHT.TTHCCHHHCCTS.........................T CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........................x RF
  Hist_deacetyl   5 pkRlsaileslaesvglldelelliqpseatkeellkvHskeYlelleslsnelkkkeeakekeleeias.........................k 75 
                    p+R++ +++sl+e+ g+l+++e  i+p++a  ++l+ +HskeY+++l +++++lk+ +++ +ke+  +++                          
     EFC38663.1  52 PSRSE-LVHSLIEAFGILEKVES-IEPEKALMKDLQIYHSKEYVHALYKIDKSLKARSSLGDKEEDMSDEevssdessnsdnddatdieelkkqfG 145
                    67777.99******9***99886.********************************999999987655559999*****99999999988876542 PP

                    SSSSSTHCTTTCCHHHHHHHHHHHHHHHHHH...TTSS..SEEEETT.SS--TT-BTTB-BTTBSS-HHHHHHHHHHHCC-SS-EEEEE-SSS--H CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxx..xxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl  76 lldddtpvspktlkaallavgavleavdavl...sgsv..kaafvlv.rPpgHHakaseasGFClvNnvaiaikylqakhelkrvailDvDvHhGn 165
                     l dd   +++++++al+  g++ + +++v    ++s+  ++  +l+ ++++HHa++s+a GFC+vN+v++    +++    ++++ +D+D+HhG+
     EFC38663.1 146 -LVDDAHDFKGMFNYALYIGGSCNAIAKEVNhflKSSSseERLTILNfEGGRHHARKSRAAGFCYVNDVVMLSLLIKR----RKILCIDIDIHHGD 236
                    .45668889999999987766666666655544455443344455557**********************99987766....8************* PP

                    HHHHHCTT-TTEEEEEEEE-CCTSTTSS--TT---SGGGTTSEEEEEE-TT-BHHHHHHHHHHCHHHHHCCH--SEEEEEE-STTBTTSTT-S-BB CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 166 GteeafysdpdvltlSiHryegifyPgtgaledlgegkgkgfnlnvpleegtgdeeylkvfeeilrpvleefkPdlilvsaGfDalkgdplgelnl 261
                    Gteeaf s+++v+t+S+H++++++yPgtg++++ g+g+gk +nlnvpl+eg +d+++ ++f++++ + +e+f+P+++++ +G+D l+gdplg +nl
     EFC38663.1 237 GTEEAFFSSERVFTVSFHQFGPGLYPGTGTTDNNGTGRGKYHNLNVPLKEGLSDKNFERIFTSVIAKSFEKFEPEVVILVMGADNLNGDPLGTWNL 332
                    ************************************************************************************************ PP

                    -HHHHHHHHHHHCCCHGS-G.EEEEE-S---HHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 262 svegykeltkklaeladkvkkvvllleGGYnlealaravtav 303
                    s e ++++t+ +++ +++   ++++++GGYn  ++a a++ v
     EFC38663.1 333 SLESFEYVTNFVKNELKSK-VTIIVGGGGYNYIHTAIAYATV 373
                    **************99954.78*********97777666655 PP

>> DUF1256  Protein of unknown function (DUF1256)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   1.4e-05      0.12       6      44 ..     290     328 ..     286     333 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.4e-05
     DUF1256   6 dknaleelsellsseikkvkeeivivciGtdrstgdsLg 44 
                 dkn    +++++ ++++k + e+vi+++G d++ gd Lg
  EFC38663.1 290 DKNFERIFTSVIAKSFEKFEPEVVILVMGADNLNGDPLG 328
                 6777778899999999999******************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (442 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       741  (0.0413297); expected 358.6 (0.02)
Passed bias filter:                      435  (0.0242624); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2666.91
//
Query:       EFC38664.1  [L=1375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0046   16.5   4.5      0.017   14.7   4.2    2.1  2  BID       BH3 interacting domain (BID)
  ------ inclusion threshold ------
       0.48   10.1  11.4        3.7    7.3   4.1    2.4  2  DUF842    Eukaryotic protein of unknown function (DUF842)
        1.9    8.6   5.7        7.4    6.8   5.1    2.4  2  Uds1      Up-regulated During Septation
        4.8    7.7   9.3       0.85   10.1   2.1    2.7  2  DUF4208   Domain of unknown function (DUF4208)


Domain annotation for each model (and alignments):
>> BID  BH3 interacting domain (BID)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.3   5.8e+03      51      66 ..     208     223 ..     186     228 .. 0.70
   2 !   14.7   4.2   3.7e-06     0.017      28     153 ..    1114    1238 ..    1109    1259 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.3
                 XS.XSSXXX-S-S--- CS
         BID  51 dkddeLqtDGnrashl 66 
                  ++ e+ tDGn ++ +
  EFC38664.1 208 LSNVEMDTDGNVSGII 223
                 34579******88765 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 3.7e-06
                  XSSSHHHHHHHGGGXXXXXSXSSXS.XSSXXX-S-S---TTT-STTS-HCHHHHHHHHHHHHHHHHHHHHCCSSTTSHHHHHHHHHCHCCCCCCCCH CS
         BID   28 dseFheeLeaLgkelpvkaeleedkddeLqtDGnrashlqagrleadsesqeevirniarqLaqiGDeldksiqpklvneLaaqfvneslseedrrk 124 
                  +s+ ++ L+ ++ +l +++el++  + eL t    +s + +++l +  ++  ++ +nia+   ++ ++l + i+ +++n+ + +f +++   e+  +
  EFC38664.1 1114 ESTLRKCLAFIKDKLHAEVELKKA-QKELNTAKRNYSNSIKKELSKMGNEILNITNNIAETGKDVYERLGNIIEKNVLNKCIDEFNKKQENYEECIH 1209
                  667788899999999999999755.59*****9999999999888888888889999999999999******************************* PP

                  HHHHHHHHHHCTS--SSHCHHHHHHHHHH CS
         BID  125 kLaaaleqvmqtipkDlekekamLvltml 153 
                   + +a+e+  + + +D  k   +L+  m 
  EFC38664.1 1210 DIQKAIENFKNILLNDYCKKNNQLMKSMN 1238
                  ************************99885 PP

>> DUF842  Eukaryotic protein of unknown function (DUF842)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.7    0.0011       5.1      59     127 ..    1101    1169 ..    1082    1173 .. 0.81
   2 ?    7.3   4.1   0.00082       3.7      33      89 ..    1191    1246 ..    1185    1264 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0011
      DUF842   59 kaqkvvqqEleqfqerLqrcvmvCqdkakdklgpnssekqtakaekelekCvakCvddhiklLpkikkr 127 
                  + ++ +++E+e+ ++ L +c+   +dk++ +++ ++ +k+ ++a+++ ++ ++k   +  + + +i+++
  EFC38664.1 1101 SSNEQIEKEIEKEESTLRKCLAFIKDKLHAEVELKKAQKELNTAKRNYSNSIKKELSKMGNEILNITNN 1169
                  567889**************************8899999998888888877777666666666666555 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.00082
      DUF842   33 akCcddrkasresveqCvekCseplqkaqkvvqqEleqfqerLqrcvmvCqdkakdk 89  
                   kC d+ ++++e+ e+C+ + ++ ++++++++ ++  + +++L +++++  ++++++
  EFC38664.1 1191 NKCIDEFNKKQENYEECIHDIQKAIENFKNILLNDYCKKNNQLMKSMNTI-EEIRKS 1246
                  69*****************************************9998876.334433 PP

>> Uds1  Up-regulated During Septation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.3   5.8e+03      84     112 ..     374     402 ..     367     406 .. 0.83
   2 ?    6.8   5.1    0.0016       7.4      25     116 ..    1109    1212 ..    1099    1251 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.3
        Uds1  84 lakaeeelaeserkvdelaselekleera 112
                 l++ ee+++++ +k +  +++l+kl+++ 
  EFC38664.1 374 LNQDEESINALMQKLNLPSTDLFKLKKES 402
                 67889999999999999999999998875 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0016
        Uds1   25 elkkelkaLeerlealrkkLaletklrdaarsLsrlyssskksak.............................ssaarsnskssreslakaeeela 92  
                  e+ ke ++L + l  ++ kL  e  l++a ++L+++++++++s k                             +                   e +
  EFC38664.1 1109 EIEKEESTLRKCLAFIKDKLHAEVELKKAQKELNTAKRNYSNSIKkelskmgneilnitnniaetgkdvyerlgN-----------------IIEKN 1188
                  789**********************************99999977888888888877665444444444444442.................33344 PP

        Uds1   93 eserkvdelaselekleeraaevr 116 
                   +++ +de++++ e+ ee  ++++
  EFC38664.1 1189 VLNKCIDEFNKKQENYEECIHDIQ 1212
                  444444444444444444433333 PP

>> DUF4208  Domain of unknown function (DUF4208)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   2.1   0.00019      0.85       6      66 ..    1112    1175 ..    1107    1182 .. 0.78
   2 ?    0.6   0.8      0.18     8e+02      11      65 ..    1204    1258 ..    1195    1267 .. 0.55

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00019
     DUF4208    6 mdeeeckellrpvkksLk...rLkkltkekl.lskkerakilkkeLlkiGdfIdellkekkeekk 66  
                  ++e++++++l  +k++L+   +Lkk++ke l   k++  + +kkeL k G++I +++++  e+ k
  EFC38664.1 1112 KEESTLRKCLAFIKDKLHaevELKKAQKE-LnTAKRNYSNSIKKELSKMGNEILNITNNIAETGK 1175
                  45556999999999999844469999888.5478888899***************9998866444 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.18
     DUF4208   11 ckellrpvkksLkrLkkltkekllskkerakilkkeLlkiGdfIdellkekkeek 65  
                   +e++++++k+ +++k+   +++ +k++++ +  +++ +i + +++ l + +++ 
  EFC38664.1 1204 YEECIHDIQKAIENFKNILLNDYCKKNNQLMKSMNTIEEIRKSVSKKLSTLSHQT 1258
                  6677777777777777766665555555555555555555555555554443333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1424  (0.0794244); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.02u 0.32s 00:00:01.34 Elapsed: 00:00:00.54
# Mc/sec: 7620.83
//
Query:       EFC38665.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   9.6e-103  343.7   0.7   1.1e-102  343.5   0.7    1.0  1  DUF4419   Domain of unknown function (DUF4419)


Domain annotation for each model (and alignments):
>> DUF4419  Domain of unknown function (DUF4419)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  343.5   0.7  6.2e-107  1.1e-102       1     302 []      47     339 ..      47     339 .. 0.95

  Alignments for each domain:
  == domain 1  score: 343.5 bits;  conditional E-value: 6.2e-107
     DUF4419   1 ngfveavleAyaehlhLvlrPDdvWlaIltqlsfyvnanaeelrslfvahegkkelevkaeekle..dweelakelteeiqknvkdpslrdwilpdFsT 97 
                 n+fv +++ Ay++h++ v++PDdvWlaI+tq+s+yvn ++eelr++fv++egkk+l v   ++l   d+ +l  ++t++i+kn+kdps+r+wi+pdF+T
  EFC38665.1  47 NSFVMSAAIAYSSHHNWVIKPDDVWLAICTQFSNYVNGRSEELRDKFVDFEGKKQLIVYGGGTLMtaDYASLSLDMTTQIAKNIKDPSVREWIMPDFTT 145
                 8*********************************************************777777789******************************** PP

     DUF4419  98 ttetdkvvaavllmatlkkyfeykvsllCGiPsvtLlGekeDWekllerlekLkefg...eelkewaklLrpildrfvesfdepdseenkeFWnkivke 193
                 ttetd+++ av+lma++k+yf+y +sl+C +P+vtLlGe eDW++++er+++L ef+   + +k+w+klL p+ld+fves++  +++ +ke+Wn+++++
  EFC38665.1 146 TTETDRMIGAVVLMAAMKNYFDYMFSLCCNLPNVTLLGEVEDWVSIRERANRLLEFDtkeNCMKKWSKLLFPVLDKFVESIK--GNP-DKEWWNRVAHH 241
                 ********************************************************555599********************..656.799******99 PP

     DUF4419 194 eseegsgeselsGWitaFcvydkdgkvleeekkeeeeeeseeeealvldgveypeidtddipsglasvpvkldedngkeyelelvaGsvGvkvsseeed 292
                  ++ gsg+s+lsGWit+Fcv++++g++ +++k+ +   e++         +e+p id+d ip+g++svp+ +d dng+ y++e++aG+++++  +++ +
  EFC38665.1 242 CGG-GSGPSYLSGWITSFCVFSDKGHWVGDQKSVNIWGETT--------TMEWPIIDQDVIPRGYVSVPIVVD-DNGTIYDTEMFAGHMSTELLEDG-K 329
                 998.9************************999888776543........468********************9.999*******************9.8 PP

     DUF4419 293 tlqpvsgWal 302
                 tl+p ++Wal
  EFC38665.1 330 TLKPRADWAL 339
                 ********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       377  (0.0210274); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.55
# Mc/sec: 1878.77
//
Query:       EFC38666.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1629.18
//
Query:       EFC38667.1  [L=419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.3    9.6  12.3        1.6    9.3   0.9    3.3  3  PRESAN    Plasmodium RESA N-terminal


Domain annotation for each model (and alignments):
>> PRESAN  Plasmodium RESA N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.6    0.0032        57      63     109 ..      57     102 ..      42     105 .. 0.86
   2 ?    9.3   0.9   9.1e-05       1.6      59     118 ..     159     219 ..     126     225 .. 0.89
   3 ?    2.6   0.2     0.011   1.9e+02       3      34 ..     384     415 ..     382     418 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0032
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS-SEEEHHHHHHHHHH CS
      PRESAN  63 kkklwkeckneitkelkklekeynknfynllkkkklsidefkefins 109
                 k+ + + + n +   ++++e+++ k++  ++ +++ +++e+ke i +
  EFC38667.1  57 KTTISQSIRNCLSTIISNKEDSSRKRLDRIFSNEE-TREEIKETIFN 102
                 45566778888999999**************9999.9*****99976 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 9.1e-05
                 -HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS-SEE.EHHHHHHHHHHHHHHHHHHH CS
      PRESAN  59 peeykkklwkeckneitkelkklekeynknfynllkkkkl.sidefkefinsyrklwkkll 118
                  ++y+ +lw++  ++i+k +k +  ey  ++  l +++k+ si++ k f +  +k +++  
  EFC38667.1 159 FKNYRGQLWNHLRKNIKKQQKGIVFEYFMHLLILEESEKYgSIRDCKLFAGLPKKEFENYS 219
                 57899**************************9999*************9998888887765 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.011
                 -HHHHHHHHT-S-SEEEHHHHHHHHHHHHHHH CS
      PRESAN   3 teeelnklinslneviskkdmyiiwnyvmkne 34 
                 t++el++ i+   ++    dm+ iw y+ +n+
  EFC38667.1 384 TRNELDNCIEGWFDKGYHSDMVYIWDYFKSNH 415
                 6778888888887777788*********9886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       926  (0.0516482); expected 358.6 (0.02)
Passed bias filter:                      622  (0.0346924); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.60
# Mc/sec: 2097.19
//
Query:       EFC38668.1  [L=165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.3e-05   22.3   0.0     0.0002   21.1   0.0    1.6  1  Biotin_lipoyl_2  Biotin-lipoyl like
    0.00065   19.0   0.1    0.00076   18.8   0.1    1.2  1  HlyD_D23         Barrel-sandwich domain of CusB or HlyD membr
     0.0062   16.4   0.0     0.0095   15.7   0.0    1.4  1  Biotin_lipoyl    Biotin-requiring enzyme


Domain annotation for each model (and alignments):
>> Biotin_lipoyl_2  Biotin-lipoyl like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   3.3e-08    0.0002       7      35 ..      91     119 ..      85     127 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 3.3e-08
  Biotin_lipoyl_2   7 apvsGrVaqlnVkdGqrVkaGdvLaelDs 35 
                      ++ +G V++l+ k+Gq+Vk G+  +el+ 
       EFC38668.1  91 SQHNGIVVRLLHKEGQVVKSGQPFYELEL 119
                      6669*******************999975 PP

>> HlyD_D23  Barrel-sandwich domain of CusB or HlyD membrane-fusion
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   1.3e-07   0.00076      78     139 ..      54     117 ..       6     121 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 1.3e-07
                 XXXXXXXXXXXXXX.XXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    HlyD_D23  78 lleaarerLrllgv.seeqia.elektgkvqktvtvkapisGvVteknvreGqyvqpgdtlfti 139
                 +++ a+  +  ++v ++eq++ + +++ k  ++v++k++ +G+V+++   eGq+v+ g++ +++
  EFC38668.1  54 EFRLAKLHISEMDViKKEQLNaSFKSSSKQATVVDWKSQHNGIVVRLLHKEGQVVKSGQPFYEL 117
                 3333333444443224455541567788888999*************************99986 PP

>> Biotin_lipoyl  Biotin-requiring enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   1.6e-06    0.0095      44      72 ..      88     116 ..      43     117 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.6e-06
                    EEEBSSSEEEEEESSTTTEEE-TTCEEEE CS
  Biotin_lipoyl  44 eieapkaGvvkeilvkeGdtvevgdllak 72 
                    + +++++G+v+ +l+keG+ v++g++  +
     EFC38668.1  88 DWKSQHNGIVVRLLHKEGQVVKSGQPFYE 116
                    45799********************9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1047  (0.058397); expected 358.6 (0.02)
Passed bias filter:                      593  (0.0330749); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1056.47
//
Query:       EFC38669.1  [L=388]
Description: small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      8e-20   71.1   0.0    1.3e-19   70.4   0.0    1.3  1  Ras         Ras family
    6.6e-19   68.3   0.0    1.4e-18   67.2   0.0    1.5  1  Roc         Ras of Complex, Roc, domain of DAPkinase
    0.00014   21.3   0.0    0.00024   20.6   0.0    1.3  1  Gtr1_RagA   Gtr1/RagA G protein conserved region
    0.00016   21.1   0.0    0.00026   20.5   0.0    1.3  1  Arf         ADP-ribosylation factor family
     0.0004   20.2   0.2    0.00089   19.1   0.2    1.6  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.036   14.4   0.0       0.22   11.9   0.0    2.1  2  AAA_16      AAA ATPase domain
      0.053   13.3   0.0       0.11   12.2   0.0    1.5  1  AAA_29      P-loop containing region of AAA domain
       0.16   11.9   0.0       0.38   10.7   0.0    1.8  1  NACHT       NACHT domain
       0.19   11.7   2.9       0.14   12.2   1.1    1.7  2  DUF2076     Uncharacterized protein conserved in bacteria (DU


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.4   0.0   6.5e-23   1.3e-19       1     133 [.     214     351 ..     214     372 .. 0.87

  Alignments for each domain:
  == domain 1  score: 70.4 bits;  conditional E-value: 6.5e-23
                 EEEEEESTTSSHHHHHHHHHHSSCSSS...CTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHH..HTHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkee...yesTigvdfytkeievd.gkevkleiwDTAGqeefkslrelyyrdaegillvyditsresf..envkkw 93 
                 K++l Gds+ GKtsll+  +++   e+   y + igvdf +k +++   ++vkl++wD  G e+++s+  ++yr+a  +ll+ d +s + +  +++++ 
  EFC38669.1 214 KVLLDGDSGSGKTSLLNCSMNGLVVEQngaYYPSIGVDFAIKMFHFGdTTRVKLQLWDQCGPERYRSISMSFYRGAATVLLLLDPNSYKEYaiKSLEER 312
                 78899****************9776654449************99863789********************************9988776632678899 PP

                 HHHHHHHSTTTSEEEEEEETTTGGGG-SS-HHHHHHHHHH CS
         Ras  94 veeikrvaeenvpivLvGnKvDleekravsteegeelake 133
                 ++ ik++a++  +i+ + +K D +++r++s+e++ ++a +
  EFC38669.1 313 LKSIKKHAPK-AEIIFITTKKDKNHERCMSNEQADQFAFD 351
                 9999999995.*************************9944 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.2   0.0   7.1e-22   1.4e-18       1     120 []     214     334 ..     214     334 .. 0.84

  Alignments for each domain:
  == domain 1  score: 67.2 bits;  conditional E-value: 7.1e-22
                 EEEEESSTTSSHHHHHHCHCT-CCC-E...EETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHH.... CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsek...ekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrss.... 92 
                 Kv+l Gdsg+GKtsll+  +++ + e+   + + igvdf+ k ++ +       ++++vkl++WD +G er+rs+  +++r+aa ++l++d +s+    
  EFC38669.1 214 KVLLDGDSGSGKTSLLNCSMNGLVVEQngaYYPSIGVDFAIKMFH-FG------DTTRVKLQLWDQCGPERYRSISMSFYRGAATVLLLLDPNSYkeya 305
                 89999****************9875542227899*****998763.22......345799*******************************55432233 PP

                 .HCHHHHHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  93 .enlkeWlkelkkvagkspvilvgnkiDl 120
                  ++l+e lk++kk+a+k+ +i++ +k D+
  EFC38669.1 306 iKSLEERLKSIKKHAPKAEIIFITTKKDK 334
                 46899*********************995 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   1.2e-07   0.00024       1     130 [.     214     341 ..     214     351 .. 0.80

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.2e-07
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgati....dveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedl 95 
                 kvLL G sgsGKts+ +   + ++ ++      +i     ++  ++  +  ++l+lwD  G e++   +      + +r  + ++ ++D + +  e ++
  EFC38669.1 214 KVLLDGDSGSGKTSLLNCSMNGLVVEQNGAYYPSIgvdfAIKMFHFGDTTRVKLQLWDQCGPERYRSIS-----MSFYRGAATVLLLLDPN-SYKEYAI 306
                 8****************99999999887766666522114445555557789*********99987765.....5677888899999****.346779* PP

   Gtr1_RagA  96 etlkeilealrqyspeakvfvlihKmDliqedere 130
                 ++l+e l+ ++++ p+a++  +  K D+ +e+  +
  EFC38669.1 307 KSLEERLKSIKKHAPKAEIIFITTKKDKNHERCMS 341
                 *********************99****98876554 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   1.3e-07   0.00026      15     135 ..     213     344 ..     207     366 .. 0.75

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.3e-07
                 EEEEEEESTTSSHHHHHHHHHHSSCEE....CSSSSS..EEEEEEEE...TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEE..TT-CTTHHHHHH CS
         Arf  15 lrilllGLDnaGKtTilkklkleelvt....tvPTig..fnveelei...knlkftvwDvGGqeklRplWknYfektdavifvvD..sadreRleeake 102
                 +++ll G  ++GKt +l+  +++ +v+      P ig  f ++  ++     +k+++wD  G e+ R++  ++++   +v+ ++D  s+++  +++ +e
  EFC38669.1 213 TKVLLDGDSGSGKTSLLNCSMNGLVVEqngaYYPSIGvdFAIKMFHFgdtTRVKLQLWDQCGPERYRSISMSFYRGAATVLLLLDpnSYKEYAIKSLEE 311
                 5788888899******9876655555434448999984456777766555789********************************44455668999999 PP

                 HHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHH CS
         Arf 103 eLkalleeeelkevallvlaNKqDlpealseee 135
                  Lk++ ++   +e++++     +  + ++s+e+
  EFC38669.1 312 RLKSIKKHAPKAEIIFITTKKDKNHERCMSNEQ 344
                 999998877766666555444444455565554 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.2   4.5e-07   0.00089       4      44 ..      10      50 ..       7      52 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 4.5e-07
  F-box-like  4 LPdEiLlqIFs.yL.ppsdLlrlalVCrrWrrvaldtplLWrr 44
                LP+E++ +I   ++ + + + +l+ VCr+Wr ++  + l+W +
  EFC38669.1 10 LPNELIGEIICgHIhHVELIFSLRNVCRYWRGIC--HELIWDH 50
                9***999999646734556788***********9..6699965 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00011      0.22      27      46 ..     215     234 ..     205     273 .. 0.84
   2 ?   -0.6   0.0      0.74   1.5e+03      42      64 ..     314     336 ..     308     369 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00011
      AAA_16  27 vllsGesGvGKsslvrellr 46 
                 vll G+sG+GK+sl+++ ++
  EFC38669.1 215 VLLDGDSGSGKTSLLNCSMN 234
                 8999***********99775 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.74
      AAA_16  42 rellralekdggiflrgkcdqle 64 
                 +++++++ k+++if+++k d+++
  EFC38669.1 314 KSIKKHAPKAEIIFITTKKDKNH 336
                 67788899999******999993 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   5.7e-05      0.11      24      48 ..     214     238 ..     200     245 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.7e-05
      AAA_29  24 atlltGpsGsGKSTllDAiqalLvp 48 
                  +ll G+sGsGK++ll   +  Lv 
  EFC38669.1 214 KVLLDGDSGSGKTSLLNCSMNGLVV 238
                 479************9876666555 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00019      0.38       3      21 ..     215     233 ..     213     349 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00019
                 EEEEC-TTTCHHHHHHHHH CS
       NACHT   3 vilqGeaGsGKTtLlqkla 21 
                 v+l G++GsGKT Ll   +
  EFC38669.1 215 VLLDGDSGSGKTSLLNCSM 233
                 899***********97544 PP

>> DUF2076  Uncharacterized protein conserved in bacteria (DUF2076)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   1.1   7.2e-05      0.14      80     136 ..     145     203 ..     123     234 .. 0.50
   2 ?   -1.9   0.0       1.4   2.8e+03      54      71 ..     303     320 ..     301     351 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 7.2e-05
     DUF2076  80 eaqaqpssggFLsg.......lFGggkkerpqpspqarpaapagqalgqeeqyaaqpgyaqqqa 136
                 + q+qpss gF++g       +F ++ ++++q+++q++++ ++++   ++  ++a p     q+
  EFC38669.1 145 KPQQQPSSKGFFGGalsfigsFFSSNTQSNSQSNSQSNAQSNSQS-ITSNVVNSATPT----QN 203
                 557788999998887763333444444443333333333333332.222222222222....22 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.4
     DUF2076  54 eaaLkqanariqeLeaql 71 
                 e a+k++++r++ +++ +
  EFC38669.1 303 EYAIKSLEERLKSIKKHA 320
                 788888888888888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (388 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1302  (0.0726198); expected 358.6 (0.02)
Passed bias filter:                      817  (0.0455686); expected 358.6 (0.02)
Passed Vit filter:                       116  (0.00646996); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.72u 0.36s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 2166.58
//
Query:       EFC38670.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.9e-05   23.6   0.1      5e-05   22.9   0.1    1.3  1  DUF553          Transglutaminase-like domain
    0.00048   20.6   0.0     0.0033   17.8   0.0    2.0  1  Transglut_core  Transglutaminase-like superfamily
  ------ inclusion threshold ------
      0.054   13.7   0.0       0.43   10.8   0.0    2.0  2  Muraidase       N-acetylmuramidase


Domain annotation for each model (and alignments):
>> DUF553  Transglutaminase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.1   8.4e-09     5e-05      13     100 ..      62     148 ..      48     154 .. 0.77

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 8.4e-09
      DUF553  13 ensketiinvlewvdenikYdyekaevvetllvlWatfftlskvdskilklietpkeilktkkgiCrDYaiLTaalLlnlniskvylv 100
                 ++ +e++  +  w+ en+ Yd e   + + ++++ +++ +   +d k++    +   +  +kkg+C+ Ya L   +  +++i+kv  v
  EFC38670.1  62 SSIEEKARSIFVWICENVVYDAESFLSNQHAVYVPSEHDKFFSEDEKKMYCPTSR-LTFIQKKGVCSGYARLFKNMCIQSGIQKVSCV 148
                 345678999**************99999999999888876666666665544444.4555799******************9998765 PP

>> Transglut_core  Transglutaminase-like superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   5.6e-07    0.0033       3     102 ..      53     177 ..      51     186 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 5.6e-07
  Transglut_core   3 laeeltagakdplekakaiyewvrknveys........aprrtpgsrd............aeavle..tgkGncedfaslfvallRalGi.paRv 74 
                     l+  lt+  ++ +eka+ i  w+++nv y+        ++ + p+++d            +++ l+  ++kG+c ++a lf  ++  +Gi +  +
      EFC38670.1  53 LVTYLTKPFSSIEEKARSIFVWICENVVYDaesflsnqHAVYVPSEHDkffsedekkmycPTSRLTfiQKKGVCSGYARLFKNMCIQSGIqKVSC 147
                     5566667777888*****************999999985666666666677777778888666666679*********************77889 PP

  Transglut_core  75 vtgylsgeeekeq....svasedaHawvevyl 102
                     v+g+ +    +++       +e +H w+ v l
      EFC38670.1 148 VVGFAKL--VGFNplnpVDIKESNHEWNAVEL 177
                     9999883..23333343333444588877766 PP

>> Muraidase  N-acetylmuramidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   7.2e-05      0.43      82     132 ..       7      58 ..       3      71 .. 0.87
   2 ?    0.4   0.0      0.11   6.4e+02      64     100 ..     122     158 ..      77     170 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 7.2e-05
   Muraidase  82 eeaAlksaswGlfQimGfnykelg.yksvedfvekmseseaeqleafvrfik 132
                 ++    s+s G fQ  G++yk l  y+++++ +++  +se + l+ +v++++
  EFC38670.1   7 QQLSTLSISTGPFQSDGEHYKLLKnYEQIDAHAKSIPSSETSTLTQLVTYLT 58 
                 5566789**************9866***********************9984 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.11
   Muraidase  64 ykggaaeyerLekAaaldeeaAlksaswGlfQimGfn 100
                 +kg  + y+rL k + +++     s+  G  + +Gfn
  EFC38670.1 122 KKGVCSGYARLFKNMCIQSGIQKVSCVVGFAKLVGFN 158
                 3445788999999999*999999************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       437  (0.0243739); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2412.94
//
Query:       EFC38671.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1868  (0.104189); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 1854.18
//
Query:       EFC38672.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.9e-17   62.3   0.1    8.5e-17   61.5   0.1    1.4  1  NmrA             NmrA-like family
    1.8e-09   37.8   0.0    2.8e-09   37.1   0.0    1.3  1  NAD_binding_10   NAD(P)H-binding
    4.1e-05   23.2   0.0    0.00026   20.5   0.0    2.1  2  Epimerase        NAD dependent epimerase/dehydratase family
     0.0002   20.6   0.0    0.00032   19.9   0.0    1.4  1  NAD_binding_4    Male sterility protein
     0.0002   20.4   0.1    0.00065   18.8   0.0    1.7  2  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
    0.00095   18.7   0.1     0.0052   16.2   0.0    2.0  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
     0.0017   17.8   0.0     0.0027   17.2   0.0    1.4  1  adh_short        short chain dehydrogenase
      0.009   15.2   0.8      0.031   13.4   0.1    1.9  2  Polysacc_synt_2  Polysaccharide biosynthesis protein
     0.0098   16.2   0.0       0.03   14.6   0.0    1.9  2  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
  ------ inclusion threshold ------
      0.015   15.2   0.0      0.049   13.5   0.0    2.0  2  KR               KR domain
      0.015   15.7   0.0      0.044   14.2   0.0    1.8  2  Semialdhyde_dh   Semialdehyde dehydrogenase, NAD binding doma
      0.025   14.7   0.0      0.062   13.4   0.0    1.7  1  DapB_N           Dihydrodipicolinate reductase, N-terminus
      0.028   14.7   0.0      0.053   13.8   0.0    1.5  1  TrkA_N           TrkA-N domain
      0.059   13.5   0.0       0.16   12.1   0.0    1.7  1  AcylCoA_dehyd_C  Acyl-CoA dehydrogenase C terminal
      0.086   11.9   0.1       0.61    9.1   0.0    2.0  2  RmlD_sub_bind    RmlD substrate binding domain
       0.11   13.4   0.0       0.22   12.4   0.0    1.6  1  GFO_IDH_MocA     Oxidoreductase family, NAD-binding Rossmann 


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.5   0.1   7.6e-20   8.5e-17       1     232 [.      14     256 ..      14     257 .. 0.83

  Alignments for each domain:
  == domain 1  score: 61.5 bits;  conditional E-value: 7.6e-20
                 EEESSTTSHHHHHHHHHHHH...HT-EEEEEES-S...-SHHHHHHHHSTTEEEES-TT-HHHH.HHHHTT-SEEEE---GGS-HHHHHHHHHHHHHHH CS
        NmrA   1 IlviGaTGrqGksvvrallk...aghkvralvRdt...kselakslkeaGvelvkgdlddkesl.vealkgvdvvfsvtgfyskeiedgkklvdAakea 92 
                 Il++GaTG +Gk++ + l +    g +v++lvR+    k+ela+ +++  ve ++gdl++ e++ ++++++ + vf+ t +  ++ +   +l++ + e 
  EFC38672.1  14 ILITGATGTIGKHLLKSLSEqksFGQSVKVLVRNIekaKQELANYVNNLDVEYIQGDLNQFELIpSSIFEKIERVFVLTVSEPNQPKVEEQLINKILEY 112
                 89**************9999777799********999999********************999846799***********9988888888888888774 PP

                 S...-SEEE.EEE---GG.GT.SSS---TTTHHHHHHHHHHHHC..TS-EEEEEE-EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE....- CS
        NmrA  93 G...vkhfi.ySslgddndrsnaeepavphfdsKaeieeyvral..gipytfvyagffmenflsllaqlkvgdtappedkvtllgpgnpkavll....d 181
                      k++i  S+lg+   + + + + ++h ds + i + + +   ++ y ++++++fm+nfl+       ++ +++    ++ +p n ++ +     +
  EFC38672.1 113 SkddLKQVIrLSGLGASTTI-ESNSLFRYHGDSEVVIGNLLSNKapSVSYVILRPNLFMQNFLRDDI----HSIKNSS---QFFKPRNDHGIPYhishV 203
                 33458998846888887755.5677799***********99887779999999***********433....3444443...566666655666566789 PP

                 HHHHHHHHHHHHHHHHHHH.TTEEEEE-S.EEE-HHHHHHHHHHHHTS-EEEE CS
        NmrA 182 aeeDiGafvikilkdprkl.kgkriklag.ntlsgneivelfekkigktvkYt 232
                 +++Di+ + ++il +  ++  g++++++g + l +++++e+++k+ig+++++t
  EFC38672.1 204 DVRDIADMAAQILIENPNIhGGQVYNITGpQSLNYDQVAEIISKVIGRQITWT 256
                 ************98855554888888876478*****************9986 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   0.0   2.5e-12   2.8e-09       1     160 [.      18     184 ..      18     219 .. 0.68

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 2.5e-12
                     TTTSHHHHHHHHHHHHC-..T-EEEEEETTHHHCH.HHH...CTTTCEEEE--TT-CCHHHH.HHTT-SEEEES---TCC....HHHHHHHHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellarg..ghevtalvRnpekla.ele...aeeglevvegdvtdvedlae.alkgadaVvsalggggk....deegaknivda 84 
                     GAtG +G++l+k l +++  g +v++lvRn ek++ el+   ++  +e ++gd+++ e + +  ++ ++ V++ + ++ +    +e+  ++i++ 
      EFC38672.1  18 GATGTIGKHLLKSLSEQKsfGQSVKVLVRNIEKAKqELAnyvNNLDVEYIQGDLNQFELIPSsIFEKIERVFVLTVSEPNqpkvEEQLINKILEY 112
                     9*******************99********9998633333437789999*******998865156999***999977777466455556666665 PP

                     HHHCT--EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHH.HHHHHHHH..SSSEEEEEEE-CEE-ST.--SEEEEETT CS
  NAD_binding_10  85 akeagvkRfvlvsaigvgdevpgefgewnkellkaylaakr.aaeellra..sgldwTivrpggLtdep.ttkyrvvekg 160
                       + + k+++ +s++g+         ++ ++ l +y+ + +    +ll +    + ++i+rp  ++++  + +++ ++++
      EFC38672.1 113 S-KDDLKQVIRLSGLGAST-------TIESNSLFRYHGDSEvVIGNLLSNkaPSVSYVILRPNLFMQNFlRDDIHSIKNS 184
                     5.679************95.......33445566666554415667776633589999*999998876445555555443 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   2.3e-07   0.00026       1      57 [.      14      78 ..      14     112 .. 0.78
   2 ?    0.3   0.0      0.35   3.9e+02     212     240 ..     202     230 ..     168     274 .. 0.83

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 2.3e-07
                EEEETTTSHHHHHHHHHHHHCT...SEEEEEES-STTTTCHHCHHC.....EEEE--TT-HHHHH CS
   Epimerase  1 ilVtGatGfiGsalvkallekg...yevigldrlssasntarledl.....elveldltdrsale 57
                il+tGatG iG++l+k l e++   + v +l r+ ++ ++++ + +     e +++dl + + + 
  EFC38672.1 14 ILITGATGTIGKHLLKSLSEQKsfgQSVKVLVRNIEKAKQELANYVnnldvEYIQGDLNQFELIP 78
                8********************99977788888887777777777667888888888887766554 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.35
                 EEEHHHHHHHHHHHHHHHTT-STTEEEEE CS
   Epimerase 212 flyveDvaeaillvlehvdagdkgeiyni 240
                 +++v+D+a++   +l +  +   g++yni
  EFC38672.1 202 HVDVRDIADMAAQILIENPNIHGGQVYNI 230
                 56777777777777766666666777776 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   2.9e-07   0.00032       1      42 [.      16      56 ..      16      89 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 2.9e-07
                   EE-TTSHHHHHHHHHHHHHS-.T.EEEEEE-SSSHHHHHHHHH CS
  NAD_binding_4  1 lTGaTGFLGkvLlekLLrttpev.kiyllvRaksgesaeeRle 42
                   +TGaTG +Gk+Ll+ L ++++    + +lvR+ ++  a++ l 
     EFC38672.1 16 ITGATGTIGKHLLKSLSEQKSFGqSVKVLVRNIEK--AKQELA 56
                   8****************9999779*******8855..555554 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   5.8e-07   0.00065       1      73 [.      15      91 ..      15     110 .. 0.75
   2 ?   -1.3   0.0      0.79   8.8e+02     227     269 ..     211     250 ..     177     255 .. 0.71

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 5.8e-07
   3Beta_HSD  1 vvtGgaGFlGralvkeLvrlee.lkevrvlDlrespelleelskvnvkk..viegDvtdkdkleeal.egvdvvihl 73
                ++tG++G +G++l k+L + ++  + v+vl  ++++ ++e ++ vn+ +  +i+gD+++ + +   + e+++ v++l
  EFC38672.1 15 LITGATGTIGKHLLKSLSEQKSfGQSVKVLVRNIEKAKQELANYVNNLDveYIQGDLNQFELIPSSIfEKIERVFVL 91
                69*******************988999999877776666666666666666*******9998865441555555554 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.79
   3Beta_HSD 227 lAaralqdpkkkssvagqayfisddsPvesyddfnltllkelg 269
                 +Aa+ l ++   +   gq+y i+  +  + yd+ +  ++k +g
  EFC38672.1 211 MAAQILIEN--PNIHGGQVYNITGPQSLN-YDQVAEIISKVIG 250
                 467777776..344456788888777777.8888777777666 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   4.7e-06    0.0052       1      67 [.      15      77 ..      15      91 .. 0.73
   2 ?   -0.1   0.0      0.42   4.7e+02     226     275 ..     205     258 ..     191     272 .. 0.62

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 4.7e-06
                   EEETTTSHHHHHHHHHHHHC...T-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHH CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlek...gyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDsssl 67
                   LiTG +G iG +l++ L e+   g+ v ++vr+ ++ + +++++  +      + +++ ++gDl+  + +
     EFC38672.1 15 LITGATGTIGKHLLKSLSEQksfGQSVKVLVRNIEKAK-QELANYVN------NLDVEYIQGDLNQFELI 77
                   9*****************99666778888777666644.55555432......23678899999876666 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.42
                    HHHHHHHHHHHHHCSS-....--EEE-TT-EEECHHCHHCCHHCCCHHHHHH.. CS
  GDP_Man_Dehyd 226 vkDyveamwlmlqqdkp....edyviatgethsvrefvelaflelgktiewegk 275
                    v+D++++  ++l ++ +    + y+i   ++ + ++++e+  + +g++i+w++ 
     EFC38672.1 205 VRDIADMAAQILIENPNihggQVYNITGPQSLNYDQVAEIISKVIGRQITWTKI 258
                    566666666655432211111456666667777777777777777777777643 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   2.4e-06    0.0027       3      64 ..      14      77 ..      12     129 .. 0.83

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 2.4e-06
                EEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHH CS
   adh_short  3 vlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreev 64
                +l+tGa++ IG+ + k l ++      v+   +++e++++el +   + ++ +iq+D+++ e +
  EFC38672.1 14 ILITGATGTIGKHLLKSLSEQKSFGQSVKVLVRNIEKAKQELANYvnNLDVEYIQGDLNQFELI 77
                89******************987777777777778888888888777789*******9976544 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.1   2.7e-05     0.031       1      40 [.      14      56 ..      14      79 .. 0.69
   2 ?   -0.3   0.0      0.42   4.7e+02      14      47 ..      76     109 ..      69     124 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.7e-05
                     EEEETTTSHHHHHHHHHHHHH...B-SEEEEEES-HHHHHHHH CS
  Polysacc_synt_2  1 vlvtGagGsiGselvrqilkk...kpkkiillerdElklyeie 40
                     +l+tGa+G+iG++l++ + ++     +  +l+ + E++ +e++
       EFC38672.1 14 ILITGATGTIGKHLLKSLSEQksfGQSVKVLVRNIEKAKQELA 56
                     89***************99984332222334444455555554 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.42
                      HHHHHHHHB-SEEEEEES-HHHHHHHHHH..... CS
  Polysacc_synt_2  14 lvrqilkkkpkkiillerdElklyeiekeleeel 47 
                      l+   + +k++++++l  +E ++ ++e++l +++
       EFC38672.1  76 LIPSSIFEKIERVFVLTVSEPNQPKVEEQLINKI 109
                      55566667899999*********99999965544 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   2.7e-05      0.03       1      58 [.      14      73 ..      14     100 .. 0.85
   2 ?   -3.2   0.0       8.7   9.7e+03      46      69 ..     293     315 ..     285     317 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.7e-05
                     EEEE--.SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHH.TTTCEEEEE--TTT CS
  Sacchrp_dh_NADP  1 vliiGa.GsvGqavaellarhfdvdaeitvadrskeklealaaka.lgvrfeaialdaen 58
                     +li Ga G +G+ +++ l++++++ + + v  r+ ek+++++a+  ++ ++e i+ d ++
       EFC38672.1 14 ILITGAtGTIGKHLLKSLSEQKSFGQSVKVLVRNIEKAKQELANYvNNLDVEYIQGDLNQ 73
                     7999********************99************9999987777777666666555 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 8.7
                      TTCEEEEE--TTTHHHHHHHHHTT CS
  Sacchrp_dh_NADP  46 gvrfeaialdaenyeavLaallke 69 
                      +v ++++ ++ +++++ L++ ++e
       EFC38672.1 293 NVHADFEIVTGKKPRS-LEQFIQE 315
                      5677788888888888.9988887 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   4.4e-05     0.049       2      66 ..      13      75 ..      12     122 .. 0.81
   2 ?   -2.0   0.0       2.6     3e+03      42      71 ..     185     214 ..     178     224 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 4.4e-05
                EEEEETTTSHHHHHHHHHHHHHH..S-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HH CS
          KR  2 tylitGGlGgLGlelarwlaekg..arhlvllsRsaaadedskaliaelealgaevevvaaDvsdkd 66
                + litG++G +G++l + l e+    +++ +l R+   ++++++l + ++  + +ve+++ D+ + +
  EFC38672.1 13 SILITGATGTIGKHLLKSLSEQKsfGQSVKVLVRN--IEKAKQELANYVN--NLDVEYIQGDLNQFE 75
                679*****************977678999999999..4455554444433..567888888887655 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.6
                 HHHHHHHHHTT-EEEE----TT-HHHHHHH CS
          KR  42 kaliaelealgaevevvaaDvsdkdaveal 71 
                 +++++  +++g+  ++ ++Dv d ++++a 
  EFC38672.1 185 SQFFKPRNDHGIPYHISHVDVRDIADMAAQ 214
                 456666677888889999999998888754 PP

>> Semialdhyde_dh  Semialdehyde dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   3.9e-05     0.044       2      47 ..      14      65 ..      13     113 .. 0.67
   2 ?   -2.3   0.0       5.2   5.9e+03      83     115 ..     170     205 ..     168     211 .. 0.66

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 3.9e-05
                    EEEETTTSHHHHHHHHHHHC..TSSEEEEEEEESTTTTTSBHHHHSG....G CS
  Semialdhyde_dh  2 vaivGatGyvGqellrlLee..hpevelvvllsssrsaGkklaeavk....a 47
                    + i GatG +G+ ll+ L+e  ++  ++ vl+ + ++a ++la++v+    +
      EFC38672.1 14 ILITGATGTIGKHLLKSLSEqkSFGQSVKVLVRNIEKAKQELANYVNnldvE 65
                    5689****************44444455566666668999999988855432 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 5.2
                     HHHHHHTTSEEEESSSTTTTST....TSEBE-HHHHG CS
  Semialdhyde_dh  83 apklaeagvkviDlssdfRlkd....davyvlpevnr 115
                     +++++  +++ i +ss+f +k+     ++y ++ v  
      EFC38672.1 170 MQNFLRDDIHSIKNSSQF-FKPrndhGIPYHISHVDV 205
                     567788888889999998.555444467776666655 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   5.5e-05     0.062       2      45 ..      13      56 ..      12      76 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 5.5e-05
                EEEEETTTSHHHHHHHHHHHHSTTEEE.EEEEETTCSTTTTTBHH CS
      DapB_N  2 kvavvGasGrmGkevvkaveeaedlel.vaavdrkeselegkdag 45
                +++++Ga+G++Gk+++k ++e++++   v+++ r+  e  ++++ 
  EFC38672.1 13 SILITGATGTIGKHLLKSLSEQKSFGQsVKVLVRNI-EKAKQELA 56
                599******************999965044455543.33333333 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   4.7e-05     0.053       2      70 ..      15      92 ..      14     114 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.7e-05
                EEES.-SHHHHHHHHHHHHTT...EEEEEEESSHHHHHHHHHTT.....SEEEES-TTSHHHHHHTTGGGESEEEE-S CS
      TrkA_N  2 iiiG.lGrvGrslaeeLsegg...kdvvvidkdeerveelreeg.....levvvgdatdeevLeeagiekadaviaat 70
                +i G  G++G++l++ Lse++   ++v v  ++ e++++  ++      +e+++gd  + e++ +   ek++ v ++t
  EFC38672.1 15 LITGaTGTIGKHLLKSLSEQKsfgQSVKVLVRNIEKAKQELANYvnnldVEYIQGDLNQFELIPSSIFEKIERVFVLT 92
                5666469************666**667777777777666555552232477******999999998888888777776 PP

>> AcylCoA_dehyd_C  Acyl-CoA dehydrogenase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   0.00014      0.16      68     109 ..      24      65 ..      14      67 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00014
                      HHHHHHHHHH-GGGHHHHHHHHHHHHHHHHHHHHHHHH--GG CS
  AcylCoA_dehyd_C  68 syLLledatraelFakSaevYvkyaeaevekhaefiknfkae 109
                      +  Ll+  +++++F +S++v v+  e+  ++ a++++n+++e
       EFC38672.1  24 GKHLLKSLSEQKSFGQSVKVLVRNIEKAKQELANYVNNLDVE 65 
                      44467889999***************************9987 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.0   0.00054      0.61       3      25 ..      14      36 ..      12      67 .. 0.77
   2 ?    0.4   0.0      0.26   2.9e+02     186     234 ..     205     252 ..     198     270 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00054
                   EEEESTTSHHHHHHHHHCTTTSE CS
  RmlD_sub_bind  3 ilvtGanGqlGseLakqlaeegl 25
                   il+tGa+G +G++L k+l+e++ 
     EFC38672.1 14 ILITGATGTIGKHLLKSLSEQKS 36
                   9*****************99864 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.26
                    HHHHHHHHHHHHHHCHH.GGG-EEEE---BS-EEHHHHHHHHHHHHCHT CS
  RmlD_sub_bind 186 ardlAevllqllekaaeekelagvyHlanegetswlefArailkeagad 234
                    +rd+A++ +q+l +  +  +  +vy +++ ++++  ++A+ i k +g +
     EFC38672.1 205 VRDIADMAAQILIENPN-IHGGQVYNITGPQSLNYDQVAEIISKVIGRQ 252
                    78999999999888775.5558999999999999999999998887765 PP

>> GFO_IDH_MocA  Oxidoreductase family, NAD-binding Rossmann fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   0.00019      0.22       3      86 ..      14     113 ..      12     121 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00019
                   EEEETT.SHHHHHHHHHHHHTTTTEEEEEEECSSHHHHHHH....HHHTTHEEESS........HHHHHTCT..TESEEEE-S-G.....GGHHHHH CS
  GFO_IDH_MocA   3 vaiiGa.Gkigskhlrplnesqrleevvalldpdaeraeav....aesfgveaysd........leelladp..eidavivatpn.....gtheela 79 
                   ++i Ga G ig++ l++l e++++ + v +l ++ e+a++      ++++ve  +          +        +i+ v+v t +     +  e+l+
    EFC38672.1  14 ILITGAtGTIGKHLLKSLSEQKSFGQSVKVLVRNIEKAKQElanyVNNLDVEYIQGdlnqfeliPSS----IfeKIERVFVLTVSepnqpKVEEQLI 106
                   7899*99*******************************99877777777777444355553333333....35588888888877544433366777 PP

                   HHHHHTT CS
  GFO_IDH_MocA  80 kaaleag 86 
                    ++le  
    EFC38672.1 107 NKILEYS 113
                   7777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       913  (0.0509231); expected 358.6 (0.02)
Passed bias filter:                      657  (0.0366445); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 1882.55
//
Query:       EFC38673.1  [L=522]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2851  (0.159016); expected 358.6 (0.02)
Passed bias filter:                      824  (0.0459591); expected 358.6 (0.02)
Passed Vit filter:                       104  (0.00580066); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.79u 0.34s 00:00:01.13 Elapsed: 00:00:00.52
# Mc/sec: 2995.30
//
Query:       EFC38674.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.6e-23   80.7   3.9    1.4e-22   80.0   2.7    2.0  3  Ribosomal_S3_C  Ribosomal protein S3, C-terminal domain
    8.7e-14   51.1   0.7    1.9e-13   50.0   0.7    1.6  1  KH_2            KH domain
  ------ inclusion threshold ------
       0.13   12.8   0.0       0.25   11.8   0.0    1.5  1  UN_NPL4         Nuclear pore localisation protein NPL4


Domain annotation for each model (and alignments):
>> Ribosomal_S3_C  Ribosomal protein S3, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.8   1.1e+04      25      32 ..      34      41 ..      23      50 .. 0.64
   2 ?   -2.2   0.0         1   6.2e+03      43      60 ..      75      94 ..      71     105 .. 0.67
   3 !   80.0   2.7   2.3e-26   1.4e-22       1      83 []     107     190 ..     107     190 .. 0.98

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.8
                    CC-SEEEE CS
  Ribosomal_S3_C 25 agakGiki 32
                     g  G+++
      EFC38674.1 34 DGYSGVEV 41
                    44444444 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1
                    T--EEEEEEC----..TCHH CS
  Ribosomal_S3_C 43 iarsekykeGrvpl..htlr 60
                    i ++  ++eG++ l  + ++
      EFC38674.1 75 IQKRFGFEEGKIELyaENVK 94
                    56777888999888555554 PP

  == domain 3  score: 80.0 bits;  conditional E-value: 2.3e-26
                     HHHHHHTT--HHHHHHHHHHHHHHCC-SEEEEEEEC-SS.TTT--EEEEEEC----..TCHHHH-EEEEEEEEETTEEEEEEEEE CS
  Ribosomal_S3_C   1 iaeqlekrvsfRramkkairramkagakGikiqvsGrLggaeiarsekykeGrvpl..htlradidyavaeaktkyGiiGvkVwI 83 
                     ++++l ++v++R+a++ ++r +m++gakG  ++vsG+L+ a++a+s+k++eG+++   +++++++d av+++ +k+G++G+kV++
      EFC38674.1 107 LKQKLMEGVAVRKACYGVLRFVMDSGAKGGAVIVSGKLR-AQRAKSMKFAEGYMIRtgQPVKDYVDIAVRHVYMKQGVLGIKVKV 190
                     5799***********************************.*******************************************97 PP

>> KH_2  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.0   0.7   3.1e-17   1.9e-13       1      76 [.      22      96 ..      22      98 .. 0.96

  Alignments for each domain:
  == domain 1  score: 50.0 bits;  conditional E-value: 3.1e-17
                HHHHHHHHHTECETEEEEEEECCSCEEEEEEEESCHHHHHTGGGHHHHHHHHHHHHHHHHHHTTCEEEEEEEETTT CS
        KH_2  1 eipeslaveikkagvskveIertanrviiviresqpgivIGkgGsnikkigkelrkdieklegkkVklnivkVkkp 76
                e++e+l++e+++ g+s+ve++ t  r++i+ir+ +p+ v+G +G+++k++++ ++k+++ +e++k++l+ ++Vk++
  EFC38674.1 22 ELNEFLKRELAEDGYSGVEVRATVARTEIIIRATRPQTVVGDNGRRMKELTSVIQKRFG-FEEGKIELYAENVKNK 96
                6899****************8888**********************************8.*************986 PP

>> UN_NPL4  Nuclear pore localisation protein NPL4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   4.2e-05      0.25      25      59 ..      67     101 ..      49     117 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.2e-05
                 BHHHHHHHHHHHSS-STTT-EEESSTTCGCCCSSS CS
     UN_NPL4  25 tlktllekvaeelkfsengfslylernkttelvss 59 
                  +k+l + ++++++f+e + +ly e  k++ l + 
  EFC38674.1  67 RMKELTSVIQKRFGFEEGKIELYAENVKNKGLSAI 101
                 5799*************************999653 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       441  (0.024597); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.34s 00:00:00.92 Elapsed: 00:00:00.55
# Mc/sec: 1240.21
//
Query:       EFC38675.1  [L=478]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.2e-81  273.0   2.0    1.1e-80  271.6   2.0    1.6  1  Ins_P5_2-kin  Inositol-pentakisphosphate 2-kinase
     0.0041   16.8   0.2        1.1    8.9   0.1    2.7  2  DUF603        Protein of unknown function, DUF603
  ------ inclusion threshold ------
      0.016   15.7   0.4        4.5    7.8   0.1    3.2  3  SPG48         AP-5 complex subunit, vesicle trafficking
      0.017   15.2   0.1        1.1    9.4   0.0    2.7  2  Trans_coact   Phage late-transcription coactivator
       0.62   10.3   4.7        6.7    6.9   0.0    2.8  3  zf-piccolo    Piccolo Zn-finger


Domain annotation for each model (and alignments):
>> Ins_P5_2-kin  Inositol-pentakisphosphate 2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  271.6   2.0   3.1e-84   1.1e-80       1     331 [.      14     466 ..      14     467 .. 0.86

  Alignments for each domain:
  == domain 1  score: 271.6 bits;  conditional E-value: 3.1e-84
                   EEEE-SSEEEEEE-SS-TTTTTEEEEEEEEES............TSHHHHT-SSHHHHHHHHHHHTTHHHHT......STSB---EEEEE-HHHHHH CS
  Ins_P5_2-kin   1 YlgEGaaniVfsytgsspsalgkvLRlrKapk............sekdseskaeseeeslsfvrkvispllg......seylvdqelvrldreflee 79 
                   Y+ EG  n+++ y+g++p+++g+vLR+rK+p+            + ++se   ++e+    +vr+vi +l++      s +++++e+++l+refl+e
    EFC38675.1  14 YKCEGLGNVILGYCGNNPRFVGRVLRVRKCPRseltsnkstmdeMYSKSEGIISREDYLTIYVRDVIGSLFStcypnnSGLVDAGETISLSREFLRE 110
                   99****************************************999999999*************************99999999************* PP

                   HHHHHGGGS-HHHHHHE.EE-TT-SEEEEEE-TTSSSSS.....T.S-EEEEEE-----S..---STTS-GGGGGGGTS-HHHHHHHHHHHTTSSSS CS
  Ins_P5_2-kin  80 lnekleaerpaaRrrka.evdvakecallleDltllpgs.....k.sktitvEiKPKwGflqspsaplsaetkeikkrvcrfcahqalklkegkiee 169
                   +++k++  rp++  + + + d++++c++l++D+t+ +++     + + t++vE+KPKwG+++ ++   ++e+k++k+++crfc+ q++klk+g i++
    EFC38675.1 111 MKSKIDLVRPTQMLEYKlDFDINADCGMLMRDFTYNRKHtqktnSdDATFCVEFKPKWGMICRSEF-IKDENKPLKYETCRFCCQQLTKLKQGLITS 206
                   ***********77666568899999******************95689************888888.8999************************** PP

                   --S--HHHHTSS-HHHHHHHHHHHHHS-TTTEEEEETTEE..............................HHHHHHHHHHHHHTHHHHHHHHHTT-S CS
  Ins_P5_2-kin 170 iskycPldLfsgdearvrraleallktpqNnlkvflngkl..............................kfvellleaLlessvLerLlqlQkldr 236
                   ++k+cP +Lfs++earvr+a+e+l+++pqNn+k++ ng+l                               f++ l+ ++l+s+++e+++++Q+ldr
    EFC38675.1 207 FTKFCPTNLFSSEEARVRKAIEDLIQNPQNNMKIYINGELnwfddnnipnrdfkeelistltkyhidnldTFIKRLIFCILDSNIMECVQRMQMLDR 303
                   ***************************************************99999999999999999988999999999999************** PP

                   SHHHHHHHHHH.....................................................................HHHH.....HHHTS-HH CS
  Ins_P5_2-kin 237 lDiegllklyk....................................................................keeekkeessleesesle 265
                   +Die ++k+ +                                                                                      
    EFC38675.1 304 FDIEFVAKYVYpplkdkyksdeviqaklfdwktipewieplkaelssmdnkckefictlsgfskdvsltlenelqahhpY----------------- 383
                   ********999998877666666666666666666665555555555555555555555555555555555555555550................. PP

                   HHHHHHHHH...............................HHHHHHHH-EEEEEESS--SEEEEETTTTEEEEEEEEEE------TTHHHHHHHHHH CS
  Ins_P5_2-kin 266 ealelldky...............................llaatlkDCSimirlsssaesrelsqsrgrafsyevkviDLDpKsakklekwvkldr 331
                                                           l+a+ +kDCS+mi++      ++   +++ +++y++ v+DLDpK ++k++++  +d+
    EFC38675.1 384 --------TnikphlksldefvkectieneeflwhilrmyLIAHGIKDCSVMITF------NVTRGENQLDHDYDIGVVDLDPKLVSKVTSYLVQDQ 466
                   ........05555555555555555555555555555555***************......9999999*************************9998 PP

>> DUF603  Protein of unknown function, DUF603
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.0    0.0044        16      89     143 ..     197     249 ..     192     270 .. 0.88
   2 !    8.9   0.1   0.00031       1.1     144     175 ..     390     421 ..     337     426 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0044
      DUF603  89 anlelgfirafkqyssvelfsmrtkienlraeidalnkasskknkqvvngeinsl 143
                 ++l+ g+i +f ++   +lfs +     +r  i+ l +   ++ k  +nge+n +
  EFC38675.1 197 TKLKQGLITSFTKFCPTNLFSSEE--ARVRKAIEDLIQNPQNNMKIYINGELNWF 249
                 67999***************9765..578999*****9999999*******9965 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00031
      DUF603 144 kseldeyikecsiremelyyecmkklatanea 175
                    lde++kec+i + e+ +  ++    a+++
  EFC38675.1 390 LKSLDEFVKECTIENEEFLWHILRMYLIAHGI 421
                 3469*************999988877777665 PP

>> SPG48  AP-5 complex subunit, vesicle trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.8   6.4e+03      72     108 ..      82     117 ..      72     119 .. 0.64
   2 ?    7.8   0.1    0.0013       4.5      86     115 ..     183     213 ..     171     216 .. 0.88
   3 ?    4.3   0.0     0.015        54       4      32 ..     289     318 ..     286     330 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.8
       SPG48  72 tlftsvlseefadpvlafetvqflrenlekLlkstsl 108
                 +lf+++  ++ +  v a et+++ re+l++++++ +l
  EFC38675.1  82 SLFSTCYPNN-SGLVDAGETISLSREFLREMKSKIDL 117
                 4444444444.33455889999999999888887655 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0013
       SPG48  86 vlafetvqflrenlekLlks.tsllkqyfPn 115
                  l +et++f+ ++l+kL++   + +++++P+
  EFC38675.1 183 PLKYETCRFCCQQLTKLKQGlITSFTKFCPT 213
                 5778****************99********6 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.015
       SPG48   4 aclveavklLdllcrldsslvar.vlptik 32 
                 + ++e+v+ +++l r d ++va+ v+p +k
  EFC38675.1 289 SNIMECVQRMQMLDRFDIEFVAKyVYPPLK 318
                 6799*****************984566666 PP

>> Trans_coact  Phage late-transcription coactivator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.039   1.4e+02       7      39 ..     226     261 ..     220     269 .. 0.74
   2 ?    9.4   0.0   0.00031       1.1      31      52 ..     303     324 ..     288     332 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.039
  Trans_coact   7 eIEelvaeeg...lsYlEAvlewceendieeeqvpk 39 
                   IE l ++ +     Y+   l w ++n+i+  +++ 
   EFC38675.1 226 AIEDLIQNPQnnmKIYINGELNWFDDNNIPNRDFKE 261
                  57777777432434599999**********999875 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00031
  Trans_coact  31 dieeeqvpklIskpLkeKikaE 52 
                   +++e v+k++++pLk+K k++
   EFC38675.1 303 RFDIEFVAKYVYPPLKDKYKSD 324
                  579999************9864 PP

>> zf-piccolo  Piccolo Zn-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       3.2   1.1e+04      23      38 ..      16      31 ..       9      32 .. 0.70
   2 ?    4.1   0.6     0.014        52       5      30 ..     171     196 ..     167     199 .. 0.88
   3 ?    6.9   0.0    0.0019       6.7      25      46 ..     354     375 ..     348     379 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.2
  zf-piccolo 23 CteCkkqvCnlCGFnp 38
                C    +++   CG np
  EFC38675.1 16 CEGLGNVILGYCGNNP 31
                5555567777899887 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.014
  zf-piccolo   5 lCktelnvgskeppnyntCteCkkqv 30 
                 +C+ e     ++p  y+tC  C +q+
  EFC38675.1 171 ICRSEFIKDENKPLKYETCRFCCQQL 196
                 89*99999999**********98875 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0019
  zf-piccolo  25 eCkkqvCnlCGFnptphltekk 46 
                 +Ck+ +C l GF+   +lt ++
  EFC38675.1 354 KCKEFICTLSGFSKDVSLTLEN 375
                 8************987777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (478 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       680  (0.0379274); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 2744.12
//
Query:       EFC38676.1  [L=192]
Description: Hypothetical protein NAEGRDRAFT_73487 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.2e-07   30.1   0.1    7.4e-07   28.9   0.1    1.7  1  F-box       F-box domain
    5.6e-06   26.1   0.1    1.2e-05   25.1   0.1    1.6  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   0.1   8.2e-11   7.4e-07       3      38 ..      64     100 ..      62     107 .. 0.92

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 8.2e-11
                 HHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHT CS
       F-box   3 lsrLPsevlrhILerLplsd.llalrrVSkgwrilid 38 
                 +s+LP+e+l++I+++L+++  +++lrr  k w+ +  
  EFC38676.1  64 FSCLPDELLMEIFSYLSPIPnYIRLRRLNKDWKVYFE 100
                 9*******************************98765 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.1   1.3e-09   1.2e-05       2      32 ..      65      96 ..      64     110 .. 0.87

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 1.3e-09
  F-box-like  2 srLPdEiLlqIFsyL.ppsdLlrlalVCrrWr 32
                s LPdE+L++IFsyL p   ++rl++  ++W+
  EFC38676.1 65 SCLPDELLMEIFSYLsPIPNYIRLRRLNKDWK 96
                68*************6666************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.34s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1086.46
//
Query:       EFC38677.1  [L=658]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.3e-05   22.2   0.1    0.00018   21.1   0.1    1.6  1  HPS3_N          Hermansky-Pudlak syndrome 3
  ------ inclusion threshold ------
      0.043   13.2   1.5      0.065   12.6   1.5    1.2  1  DUF3295         Protein of unknown function (DUF3295)
      0.074   12.2   4.8       0.12   11.5   4.8    1.2  1  Astro_capsid_p  Turkey astrovirus capsid protein
      0.085   13.2   0.3          6    7.2   0.0    3.1  3  ANAPC4_WD40     Anaphase-promoting complex subunit 4 WD40 dom
        6.5    4.7  11.0         10    4.1  11.0    1.2  1  DNA_pol_phi     DNA polymerase phi


Domain annotation for each model (and alignments):
>> HPS3_N  Hermansky-Pudlak syndrome 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.1   4.9e-08   0.00018      12      81 ..      66     134 ..      54     177 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 4.9e-08
      HPS3_N  12 evvsveqeptavcaagdkLlvatesgcvevydleeeeckvlcrfstvdkvlk.iaysesGdyvatlEeknk 81 
                 ++ s++   +a+c  + +L+va++++++ vyd+e+ e k   ++st d + + ++  + G++++ + +  k
  EFC38677.1  66 DCSSIRATCVATCQKKKELFVACTDCKIRVYDVESRELKR--TISTFDYIPTrMVVGDEGEFIVFVTNSRK 134
                 566677777888888877******999*****98777775..99999999766999999999997755444 PP

>> DUF3295  Protein of unknown function (DUF3295)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   1.5   1.8e-05     0.065     237     302 ..     381     445 ..     354     447 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.8e-05
     DUF3295 237 slsdalkkksslseaqkkqtsfkdevatrtikessaededaiesdd.deidESAIedddddssdWED 302
                  lsdal     ++ +  k+ +f+ +v+t + +e+++ de++   dd +e + S + d+dd++++ ED
  EFC38677.1 381 ILSDALAYF--MNIQFPKNVMFRFNVSTPSETENTEGDENHEMEDDeEESSKSQVKDEDDEEEEEED 445
                 566666333..455678999********777765665655554555477*******99998877666 PP

>> Astro_capsid_p  Turkey astrovirus capsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   4.8   3.3e-05      0.12     182     259 ..     376     445 ..     366     447 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 3.3e-05
                     TT--B---TTTTTSSS.---TT-EEEEEEESS--XXXX....XXXX......XXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Astro_capsid_p 182 ndkayladqvllhlit.pppqavqllfemkttvpqeralaegederktgaeeeisdpsdeedeevsdeetdtevesdeD 259
                      +++y+  ++l+++++  +p++v  +f+ +++ p+e++ +eg+++++++ +ee s +s+        +++d e e++eD
      EFC38677.1 376 YNNEYILSDALAYFMNiQFPKNV--MFRFNVSTPSETENTEGDENHEMEDDEEESSKSQV-------KDEDDEEEEEED 445
                     57889988888887752789999..77777777777775555555543333332222222.......333333333333 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0    0.0017         6      48      77 ..      79     108 ..      63     118 .. 0.83
   2 ?    1.7   0.1     0.093   3.3e+02      31      91 ..     152     211 ..     117     212 .. 0.66
   3 ?   -0.6   0.0      0.46   1.6e+03      14      53 ..     284     325 ..     274     363 .. 0.56

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0017
  ANAPC4_WD40  48 pdgklLavaysdgevrlldaesgkvvhsls 77 
                  ++ k L va+ d ++r++d+es ++ +++s
   EFC38677.1  79 QKKKELFVACTDCKIRVYDVESRELKRTIS 108
                  567889****************99877665 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.093
  ANAPC4_WD40  31 tleedkedsevrsLaW.kpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgWge 91 
                  ++  +k++s+  +L + k   ++++  ++  ++ +lda sg +  ++  +++k+v++l + e
   EFC38677.1 152 EV--CKDNSSKCELIYrKATSEIFVANWKAHKILVLDAISGSLKYEIANENTKSVQSLYYDE 211
                  33..3444333444440456677777888899**************9999999999998865 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.46
  ANAPC4_WD40  14 tedgellvfRlngqrvwtl..eedkedsevrsLaWkpdgklL 53 
                  ++++ +++f  n +++++   + +++++ v   +++p+++ L
   EFC38677.1 284 SQQSLVYLFDRNSKKLVSKinTVHENSRDVLRYSYNPSNNEL 325
                  555556666555555554444445556666666666655444 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1  11.0    0.0029        10     642     681 ..     411     444 ..     399     470 .. 0.52

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0029
  DNA_pol_phi 642 dedeeddeeeeeeddeededseedddeeesdedeededde 681
                  ++ e d+++e+e+d+ee+++s+       +ded+e+e++e
   EFC38677.1 411 ENTEGDENHEMEDDEEESSKSQ------VKDEDDEEEEEE 444
                  1222222222222222222222......111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (658 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1480  (0.0825478); expected 358.6 (0.02)
Passed bias filter:                      712  (0.0397122); expected 358.6 (0.02)
Passed Vit filter:                       109  (0.00607954); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.82u 0.31s 00:00:01.12 Elapsed: 00:00:00.49
# Mc/sec: 4041.59
//
Query:       EFC38678.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.035   14.0   0.0      0.073   13.0   0.0    1.4  1  DHOase    Dihydro-orotase-like


Domain annotation for each model (and alignments):
>> DHOase  Dihydro-orotase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   4.1e-06     0.073      69     117 ..     123     173 ..     118     181 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 4.1e-06
      DHOase  69 feglkkaeLdqalkaiaeDDevtnqsavqdfelarfyGvqLkG..vCeaek 117
                  +g+ +aeL++ +    ++++ tnq +  + elarf  +q+k   +Ce+ +
  EFC38678.1 123 IDGFLRAELQTHINCLNNNEKCTNQQSNPSIELARFIISQIKSvfNCEQSN 173
                 68999**************************************999*9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1023  (0.0570584); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2420.90
//
Query:       EFC38679.1  [L=103]
Description: histone H4 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.7e-10   40.3   0.1    3.3e-10   40.0   0.1    1.1  1  CENP-T_C        Centromere kinetochore component CENP-T histo
    2.3e-05   24.8   0.1    2.6e-05   24.6   0.1    1.2  1  Histone         Core histone H2A/H2B/H3/H4
    7.3e-05   22.9   0.1     0.0001   22.4   0.1    1.3  1  TAF             TATA box binding protein associated factor (T
    0.00012   22.3   0.0    0.00017   21.8   0.0    1.3  1  CBFD_NFYB_HMF   Histone-like transcription factor (CBF/NF-Y) 
    0.00014   22.1   0.2    0.00017   21.9   0.2    1.3  1  CENP-S          CENP-S protein
    0.00054   20.0   0.0    0.00066   19.7   0.0    1.1  1  TFIID-31kDa     Transcription initiation factor IID, 31kD sub
      0.007   16.3   0.1     0.0099   15.9   0.1    1.2  1  Bromo_TP        Bromodomain associated
  ------ inclusion threshold ------
      0.029   14.3   0.2      0.035   14.0   0.2    1.2  1  Ribosomal_S17e  Ribosomal S17


Domain annotation for each model (and alignments):
>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.0   0.1   1.5e-13   3.3e-10      13      79 ..      30      96 ..      20      99 .. 0.87

  Alignments for each domain:
  == domain 1  score: 40.0 bits;  conditional E-value: 1.5e-13
    CENP-T_C 13 vkklakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilLmkrqrk 79
                + k a r   ++g  ++++ + ++   +++++f+e v +D  +y++Ha+RKt+ + Dv+  +krq++
  EFC38679.1 30 ITKPAIRRLARRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALKRQGR 96
                45555555555677889************************************************86 PP

>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.1   1.1e-08   2.6e-05      77     129 ..      40      92 ..      16      94 .. 0.88

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 1.1e-08
                 TTSSSXEEXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXSEEXHHHHHHHHH CS
     Histone  77 sekedlrisaeavlalqealEallvelfeeAnllakhaKRvTitpkDiqlArr 129
                 +++  +ris++  +   ++l+++l+ +  +A  +++ha+R+T+t+ D+  A++
  EFC38679.1  40 RRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALK 92 
                 467788999999999999******************************99987 PP

>> TAF  TATA box binding protein associated factor (TAF)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.1   4.5e-08    0.0001       5      66 .]      31      92 ..      27      92 .. 0.85

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 4.5e-08
                -HHHHHHHHHHTT---B-HHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-SSB-HHHHHHHH- CS
         TAF  5 pkesvkviAeslGitnLsdeaaalLaedveyrlkeivqeaakfmrhskRqkLtvaDvdsALr 66
                +k +++ +A   G++ +s     +    ++  l +++++a+ +++h++R++ t+ Dv +AL+
  EFC38679.1 31 TKPAIRRLARRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALK 92
                66677888888888888877777777777888999*************************98 PP

>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.0   7.5e-08   0.00017       7      65 .]      34      91 ..      28      91 .. 0.91

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 7.5e-08
                   HHHHHHHCCTTXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF  7 rvkkImksdpdarkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65
                   +++++ +   ++++i+ +  +    +++ f+e + + A+ ++++++rKt++  ++  A+
     EFC38679.1 34 AIRRLARRG-GVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYAL 91
                   578888888.999999999999999*****************************98876 PP

>> CENP-S  CENP-S protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.2   7.7e-08   0.00017      40      73 ..      61      94 ..      23      97 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 7.7e-08
      CENP-S 40 kqlenlakDLeaFakHAkRstittdDvlLlaRrn 73
                + len+ +D  ++ +HA+R+t+t  Dv+  ++r+
  EFC38679.1 61 NFLENVIRDAVTYTEHARRKTVTSMDVVYALKRQ 94
                56899**********************9998885 PP

>> TFIID-31kDa  Transcription initiation factor IID, 31kD subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.0     3e-07   0.00066      11      70 ..      35      94 ..      31     101 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 3e-07
  TFIID-31kDa 11 ihliLaslgvteyeerVvlqLldfayrytssvLedAkvlaehakkkevslddvrlAiqsr 70
                 i+ + +  gv+ ++ ++++    +  ++  +v++dA ++ eha++k+v+  dv  A++ +
   EFC38679.1 35 IRRLARRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALKRQ 94
                 566667789999999999999999******************************999865 PP

>> Bromo_TP  Bromodomain associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.1   4.4e-06    0.0099      35      70 ..      58      93 ..      46      97 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 4.4e-06
                HHHHHHHHHHHHHHHHHTTSS-SS--HHHHHHHHHH CS
    Bromo_TP 35 iaqkYirelgeqaksfaehagRseptlkDvvltLqe 70
                +++++++++ ++a  + eha+R ++t  Dvv +L++
  EFC38679.1 58 VLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALKR 93
                78899999**************************97 PP

>> Ribosomal_S17e  Ribosomal S17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.2   1.5e-05     0.035      43      86 ..      20      64 ..      14      93 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.5e-05
                    -SHHHHHHHHHHHHHHHH.TTSS--SS---HHHHHHHHHHH---- CS
  Ribosomal_S17e 43 skklrnkiaGyvthlmkr.iqkgpvrgislklqeeererrdnyvp 86
                     k lr +iaG ++  ++r  ++g v+ is ++ +e r   +n+  
      EFC38679.1 20 KKVLRDNIAGITKPAIRRlARRGGVKRISGQIYDETRTVLKNFLE 64
                    5789**************6689***********999987777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       722  (0.04027); expected 358.6 (0.02)
Passed bias filter:                      587  (0.0327403); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.45u 0.27s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 700.62
//
Query:       EFC38680.1  [L=486]
Description: Hypothetical protein NAEGRDRAFT_73501 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00065   19.5   0.6     0.0017   18.1   0.6    1.7  1  F-box     F-box domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.6   9.7e-08    0.0017       3      38 ..       6      42 ..       5      45 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 9.7e-08
                HHHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHT CS
       F-box  3 lsrLPsevlrhILerLplsd.llalrrVSkgwrilid 38
                +s L+s+ + +I ++L+ sd +++ r+V++  +++i+
  EFC38680.1  6 FSVLSSDSVFDICKFLSASDiVFNVRSVCRATYQCIN 42
                899********************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       481  (0.026828); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.23s 00:00:00.73 Elapsed: 00:00:00.40
# Mc/sec: 3644.88
//
Query:       EFC38681.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-32  113.1   0.3    1.4e-32  112.8   0.3    1.1  1  adh_short       short chain dehydrogenase
    1.3e-25   90.4   0.0    1.5e-25   90.1   0.0    1.0  1  adh_short_C2    Enoyl-(Acyl carrier protein) reductase
    6.6e-08   32.7   0.1    8.5e-08   32.3   0.1    1.1  1  KR              KR domain
     0.0059   16.1   0.0      0.009   15.6   0.0    1.2  1  Terminase_3     Phage terminase large subunit
  ------ inclusion threshold ------
      0.011   15.7   0.0      0.016   15.1   0.0    1.4  1  NAD_binding_10  NAD(P)H-binding
      0.012   15.1   0.0      0.018   14.4   0.0    1.3  1  GDP_Man_Dehyd   GDP-mannose 4,6 dehydratase
       0.02   14.1   0.7        0.1   11.7   0.1    2.1  2  NAD_binding_4   Male sterility protein
      0.038   14.1   0.1      0.063   13.4   0.1    1.3  1  DUF2120         Uncharacterized protein conserved in archaea 
      0.086   12.4   0.0       0.12   11.9   0.0    1.3  1  NmrA            NmrA-like family


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  112.8   0.3   6.9e-36   1.4e-32       2     189 ..       7     199 ..       6     204 .. 0.88

  Alignments for each domain:
  == domain 1  score: 112.8 bits;  conditional E-value: 6.9e-36
                 EEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT.TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---S...S--SSGGGC CS
   adh_short   2 vvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee.gakalaiqvDvtdreevealvekavkklgkldvLvnNAGi...tgsgpfsel 96 
                 +vl tGas+GIG+ + k+l+  G +v+++ r ++++ + +++lkee ++k+++ +++v+d+e++++lvek +++  + +vL+nNAGi    ++++  + 
  EFC38681.1   7 TVLLTGASRGIGLHLTKHLLLGGKTVYATCRDPSNA-KSLQQLKEEySEKLIIEALTVNDEESIKTLVEKLRNNNRTFNVLINNAGIystMQKETLLNS 104
                 69**************************99999988.8899999999****************************************864444444555 PP

                 SHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGG....TSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHHHHH CS
   adh_short  97 seeewervievNltgvflltravlpamlkqssGrIvnvsSvag....kvpvagvaaYsAsKaavagltrslakelaptgirvnavaPGlvdTdmake 189
                 +++ +  ++evN ++++l+t+++++a l ++++ Ivn+sS+ g      + + +++Y++sKaa++++t+ ++ el +  +  ++v+PG v Tdm  e
  EFC38681.1 105 TKSSMLGTFEVNCVAPMLITQHLYNAKLLEKNALIVNISSIMGsiqgTTQAKRGVSYCCSKAALNMFTKMVSIELPN--VCSISVHPGWVITDMGGE 199
                 55558888******************778**********98872221455667889******************986..9999***********876 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.1   0.0   7.7e-29   1.5e-25       1     180 [.      12     198 ..      12     213 .. 0.91

  Alignments for each domain:
  == domain 1  score: 90.1 bits;  conditional E-value: 7.7e-29
                   TTTTSHHHHHHHHHHHTT-EEEEEESSGGHHHHHHHHHHHTTSE.E.EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EG.CSS-GGGH-HHH CS
  adh_short_C2   1 GaasgIGraiAkalaeeGaevvltdlneeakkrveelaeelgae.v.lecDVtdeeqvealveevvekfgklDilvnnagiapk.lkgpfletsree 94 
                   Ga +gIG ++ k+l   G +v +t ++ +++k++++l+ee++++ +  ++ V+dee++++lve+++++  ++++l+nnagi  +  k+ +l+ ++++
    EFC38681.1  12 GASRGIGLHLTKHLLLGGKTVYATCRDPSNAKSLQQLKEEYSEKlIiEALTVNDEESIKTLVEKLRNNNRTFNVLINNAGIYSTmQKETLLNSTKSS 108
                   999*****************************************745899**********************************9999999****** PP

                   HHHHHHHHTHHHHHHHHHHHH..HCTSCCEEEEEEEGGGT.SBSTTTT...HHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTGGG CS
  adh_short_C2  95 fdraldvnlyslfllakaalp..lmkeggsivnlssvgae.rvvpnyn...aygaaKaalealtrylAvelgpkgiRvNavspgpikTlaas 180
                   +  +++vn+ + +l+++++ +  l+++++ ivn+ss+ ++ +++++ +    y+ +Kaal+ +t+ +  el +  +   +v+pg++ T++  
    EFC38681.1 109 MLGTFEVNCVAPMLITQHLYNakLLEKNALIVNISSIMGSiQGTTQAKrgvSYCCSKAALNMFTKMVSIELPN--VCSISVHPGWVITDMGG 198
                   *******************99999**********999655155555547899*******************87..8888999******9964 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.3   0.1   4.3e-11   8.5e-08       2     148 ..       7     156 ..       6     189 .. 0.76

  Alignments for each domain:
  == domain 1  score: 32.3 bits;  conditional E-value: 4.3e-11
                 EEEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHT.T-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE----...----- CS
          KR   2 tylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaeleal.gaevevvaaDvsdkdavealleeikaeeppikGvihaAgv...lrdkl 96 
                 t+l+tG+  g+Gl+l+++l+  g +++  + R+ +++++    +++l++    +  + a+ v d++++++l+e++++++++ +  i+ Ag+   +++++
  EFC38681.1   7 TVLLTGASRGIGLHLTKHLLL-GGKTVYATCRD-PSNAK---SLQQLKEEySEKLIIEALTVNDEESIKTLVEKLRNNNRTFNVLINNAGIystMQKET 100
                 689****************96.6688999****.44444...4566655536688888899*****************************833356899 PP

                 TTT--HHHHHHHHTTTTHHHHHHHHHTTT....S--SEEEEEEEHHHHH--TT-HH CS
          KR  97 leemtaedleqvlapKvkGawnLhelled....esldffvlfSSiagllgsagqan 148
                 l + t++++   ++  + +   + + l +    e+  ++v +SSi g +  ++qa+
  EFC38681.1 101 LLNSTKSSMLGTFEVNCVAPMLITQHLYNakllEKNALIVNISSIMGSIQGTTQAK 156
                 99****99999999888887666666655444477788999999999888888874 PP

>> Terminase_3  Phage terminase large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   4.5e-06     0.009      75     136 ..      24      88 ..      18     113 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 4.5e-06
  Terminase_3  75 elengskflFkglddpaklkSiknlsdlwlE....Easevseed.idelvetlrapeqekqiilsfN 136
                  +l  g k ++  ++dp + kS+++l+  + E    Ea +v+ e+ i++lve+lr  +++++  +  N
   EFC38681.1  24 HLLLGGKTVYATCRDPSNAKSLQQLKEEYSEkliiEALTVNDEEsIKTLVEKLR--NNNRTFNVLIN 88 
                  56678999***************6655443333338888988777*********..55555555555 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.0   8.2e-06     0.016       1      58 [.      12      73 ..      12     107 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 8.2e-06
                    TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHH...CT..TTCEEEE--TT-CCHHHHHH CS
  NAD_binding_10  1 GAtGkvGrllvkellargghevtalvRnpeklaele...ae..eglevvegdvtdvedlaeal 58
                    GA+ ++G +l+k+ll  g  +v a  R+p+ +++l+   +e  e+l +  + v+d+e+++  +
      EFC38681.1 12 GASRGIGLHLTKHLLLGG-KTVYATCRDPSNAKSLQqlkEEysEKLIIEALTVNDEESIKTLV 73
                    9***************95.9*********9998776332222134434446777777777666 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.0   9.3e-06     0.018       1      75 [.       9      77 ..       9      81 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 9.3e-06
                   EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevq 75
                   L TG +  iG +l+++Ll  g +v+ ++r+ s+  ++++++l++    e++e+l +    ++D++s++ l+++ +
     EFC38681.1  9 LLTGASRGIGLHLTKHLLLGGKTVYATCRDPSN--AKSLQQLKE----EYSEKLIIEALTVNDEESIKTLVEKLR 77
                   67888888********************99886..679999975....45789*****************99875 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   5.2e-05       0.1       1      57 [.      10      64 ..      10     116 .. 0.89
   2 ?    0.4   0.0      0.15   2.9e+02     205     240 ..     139     174 ..     117     184 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.2e-05
                   EE-TTSHHHHHHHHHHHHHS-.TEEEEEE-SSSHHHHHHHHHHHT-SS-HHHHHHHH CS
  NAD_binding_4  1 lTGaTGFLGkvLlekLLrttpevkiyllvRaksgesaeeRleeelekkelfsallke 57
                   lTGa+  +G +L + LL   +  ++y+ +R  s+++ ++ l+ee  +k + +al+ +
     EFC38681.1 10 LTGASRGIGLHLTKHLLLGGK--TVYATCRDPSNAKSLQQLKEEYSEKLIIEALTVN 64
                   8****************9998..9********************9999998888544 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.15
                    EEE--SSST---TTSHHHHHHHHHHHH-EEES-SB- CS
  NAD_binding_4 205 iitgesktGwingsdlgirgllgliakgvlpeilgd 240
                    i+  +s  G+i+g+    rg+ +++ k +l  ++++
     EFC38681.1 139 IVNISSIMGSIQGTTQAKRGVSYCCSKAALNMFTKM 174
                    334477777777777777788888888888777666 PP

>> DUF2120  Uncharacterized protein conserved in archaea (DUF2120)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   3.1e-05     0.063      28      81 ..      32      86 ..      23     112 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.1e-05
     DUF2120 28 vrgvsrkkeeleeleskleellekldaeevdlese.eakkliekldesireveei 81
                v +++r+  ++  l++ +ee  ekl  e + +++e  +k+l+ekl ++ r+ + +
  EFC38681.1 32 VYATCRDPSNAKSLQQLKEEYSEKLIIEALTVNDEeSIKTLVEKLRNNNRTFNVL 86
                6689*****************************99789*******9988875444 PP

>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0     6e-05      0.12       1      64 [.       8      75 ..       8      98 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 6e-05
                EEESSTTSHHHHHHHHHHHHHT-EEEEEES-S.-SHHHHHHHHSTTE.EE..ES-TT-HHHHHHHHTT CS
        NmrA  1 IlviGaTGrqGksvvrallkaghkvralvRdt.kselakslkeaGve.lv..kgdlddkeslvealkg 64
                +l +Ga+  +G +++++ll  g +v a  Rd+ + + +++lke+  e l+  +  ++d+es+++++++
  EFC38681.1  8 VLLTGASRGIGLHLTKHLLLGGKTVYATCRDPsNAKSLQQLKEEYSEkLIieALTVNDEESIKTLVEK 75
                688999*9************************778899****987653444555699******99986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       944  (0.0526521); expected 358.6 (0.02)
Passed bias filter:                      631  (0.0351944); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 1553.63
//
Query:       EFC38682.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.7e-15   56.8   0.0    4.8e-15   56.0   0.0    1.4  1  PseudoU_synth_2  RNA pseudouridylate synthase


Domain annotation for each model (and alignments):
>> PseudoU_synth_2  RNA pseudouridylate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.0   0.0   2.7e-19   4.8e-15       3     160 .]      68     207 ..      66     207 .. 0.83

  Alignments for each domain:
  == domain 1  score: 56.0 bits;  conditional E-value: 2.7e-19
  PseudoU_synth_2   3 vvvnKPagvpvqpeakdgsekekettatssrae.eekkelklvhRLDkatsGllllAksseaanklakafeerkvrKkYlalvfgapeeeegai 95 
                      +++nKP+ + ++ +   +s+++k   +  +++  + +  l+ v+RLD ++ Gll+++++++++++         v+K+Yl+  +  p+e+    
       EFC38682.1  68 IALNKPESYLCSTQR--ESSNHKIIYDLLPPEFlNRNPTLGNVGRLDLDSCGLLIMTQDGDLHHRILS----ADVEKTYLVEFV-PPIESDV-- 152
                      899************..555555555554444458999****************************88....56*******986.4444333.. PP

  PseudoU_synth_2  96 kkkiskdtekqegarrkaeeldgkkavtylkvlksgsseksakvslveleletGrkhQiRvhlaa 160
                          +     q +  + + +l+ +++++ lk++ ++   +  + s + +++++G+ hQ+R+++aa
       EFC38682.1 153 ----EL---NQMKELFFSGDLQLRSEDSTLKPITNF---EYINPSTISISIVEGKYHQVRRMFAA 207
                      ....33...344446889999***************...999*********************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       446  (0.0248759); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.24s 00:00:00.74 Elapsed: 00:00:00.43
# Mc/sec: 1714.73
//
Query:       EFC38683.1  [L=1000]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   1.6e-122  399.1  48.5      2e-17   62.6   0.1    9.9 12  DUF4116          Domain of unknown function (DUF4116)
    2.5e-26   92.6   4.9    2.5e-26   92.6   4.9    2.8  2  Pkinase          Protein kinase domain
    2.1e-09   37.1   0.2    4.7e-09   35.9   0.2    1.6  1  Pkinase_Tyr      Protein tyrosine kinase
      4e-05   23.9   3.7       0.11   13.0   0.1    5.0  5  CBM60            Ca-dependent carbohydrate-binding module xyl
     0.0015   18.2   1.2       0.21   11.2   0.1    2.9  2  FTA2             Kinetochore Sim4 complex subunit FTA2
     0.0024   17.2   0.0     0.0069   15.7   0.0    1.7  2  Kinase-like      Kinase-like
      0.003   17.5   0.0         31    4.6   0.0    5.2  6  CPT_N            Carnitine O-palmitoyltransferase N-terminus
     0.0092   14.6  13.9      0.011   14.4  11.7    2.3  2  FapA             Flagellar Assembly Protein A
  ------ inclusion threshold ------
       0.05   13.9   1.2        2.5    8.4   0.1    3.6  2  RNA_pol_Rpb2_45  RNA polymerase beta subunit external 1 domai
      0.086   12.8  10.7       0.25   11.4  10.7    1.7  1  FlxA             FlxA-like protein
       0.22   11.5  18.9        0.1   12.5  11.4    2.6  2  JAKMIP_CC3       JAKMIP CC3 domain
       0.23   10.7   8.1       0.46    9.8   8.1    1.4  1  DUF3450          Protein of unknown function (DUF3450)
       0.52   10.5  17.2        1.5    9.0   6.4    4.2  4  NYD-SP28_assoc   Sperm tail C-terminal domain
        1.8    9.1  14.6         17    5.9  14.6    2.8  1  APG6_N           Apg6 coiled-coil region
        1.9    8.6  19.3        1.7    8.8  15.1    3.0  2  Tropomyosin_1    Tropomyosin like
        2.3    7.7   9.9        6.7    6.2   8.6    2.5  2  HAUS6_N          HAUS augmin-like complex subunit 6 N-terminu
        2.5    7.9  11.5        3.4    7.5   0.1    3.2  2  TRAF_BIRC3_bd    TNF receptor-associated factor BIRC3 binding
        3.3    7.4   6.6         12    5.5   6.6    1.9  1  AAA_11           AAA domain
        3.5    7.8  14.6       0.88    9.7   6.6    3.2  2  Swi5             Swi5
        7.3    7.3   8.7         50    4.6   1.2    3.0  1  SlyX             SlyX


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.2   4.7e-06    0.0042       9      37 ..       2      31 ..       1      32 [. 0.87
   2 !   56.0   0.2   2.7e-18   2.4e-15       1      48 [.      20      67 ..      20      68 .. 0.97
   3 !   48.7   0.1   4.9e-16   4.4e-13       1      49 []      70     118 ..      70     118 .. 0.97
   4 !   31.1   0.1   1.5e-10   1.4e-07       6      49 .]     100     143 ..     100     143 .. 0.97
   5 !   51.2   0.0   8.4e-17   7.6e-14       1      49 []     120     168 ..     120     168 .. 0.97
   6 !   36.6   0.1     3e-12   2.7e-09       1      36 [.     145     180 ..     145     201 .. 0.87
   7 !   29.1   0.7   6.7e-10     6e-07      15      48 ..     205     236 ..     170     237 .. 0.69
   8 !   58.7   0.1   3.7e-19   3.3e-16       1      49 []     214     262 ..     214     262 .. 0.98
   9 !   62.6   0.1   2.3e-20     2e-17       1      48 [.     239     286 ..     239     287 .. 0.96
  10 !   61.3   0.1   5.9e-20   5.3e-17       1      49 []     264     312 ..     264     312 .. 0.98
  11 !   47.0   0.3   1.7e-15   1.5e-12       1      45 [.     289     333 ..     289     337 .. 0.95
  12 !   24.1   0.3   2.3e-08   2.1e-05       1      44 [.     314     357 ..     314     360 .. 0.95

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 4.7e-06
     DUF4116  9 vkkn.gsalkylseeLknDkeivlkAvkqn 37
                +kk+ ++al++++e +knD++ +l Avk n
  EFC38683.1  2 IKKYsSNALYFANETFKNDRDAILTAVKEN 31
                5666368*********************87 PP

  == domain 2  score: 56.0 bits;  conditional E-value: 2.7e-18
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48
                Dr+ +l avk n ++l+y++e LknD+e++l+Avk+ng++l ya e +
  EFC38683.1 20 DRDAILTAVKENEFVLQYANETLKNDREFILEAVKINGKVLQYAKEIF 67
                9*******************************************9876 PP

  == domain 3  score: 48.7 bits;  conditional E-value: 4.9e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivleavk +g+al+y++e Lk+D+ei l+Avk n  a+ y+ + L+
  EFC38683.1  70 DREIVLEAVKDDGLALEYANEILKHDREIGLEAVKENAEAFLYVNNTLK 118
                 9*******************************************98886 PP

  == domain 4  score: 31.1 bits;  conditional E-value: 1.5e-10
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 leavk n +a+ y+++ Lk+D+ +vlk vkqng+ l ya e L+
  EFC38683.1 100 LEAVKENAEAFLYVNNTLKKDRGLVLKVVKQNGILLQYANELLK 143
                 89*************************************99886 PP

  == domain 5  score: 51.2 bits;  conditional E-value: 8.4e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr +vl++vk+ng  l+y++e Lk+D+eivl+Avk +g al+ya e L+
  EFC38683.1 120 DRGLVLKVVKQNGILLQYANELLKKDREIVLEAVKDDGLALEYANETLK 168
                 8899*****************************************9986 PP

  == domain 6  score: 36.6 bits;  conditional E-value: 3e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq 36 
                 DrEivleavk +g+al+y++e Lk+D+ei l+A kq
  EFC38683.1 145 DREIVLEAVKDDGLALEYANETLKQDREISLEASKQ 180
                 9****************************9999776 PP

  == domain 7  score: 29.1 bits;  conditional E-value: 6.7e-10
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 ++++  ++L+nD+ ++l+Avkqng al+ya e +
  EFC38683.1 205 YIEF--KNLRNDRKFILEAVKQNGLALEYANEIM 236
                 4555..78**********************9865 PP

  == domain 8  score: 58.7 bits;  conditional E-value: 3.7e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr ++leavk+ng+al+y++e +k+D+eivlkA++ ng al+ya e L+
  EFC38683.1 214 DRKFILEAVKQNGLALEYANEIMKRDREIVLKAIQENGLALEYANETLK 262
                 9********************************************9986 PP

  == domain 9  score: 62.6 bits;  conditional E-value: 2.3e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrEivl+a++ ng+al+y++e Lk+D+eivlkAvkqng al+y+ e +
  EFC38683.1 239 DREIVLKAIQENGLALEYANETLKKDREIVLKAVKQNGLALEYVNEIM 286
                 9*******************************************9865 PP

  == domain 10  score: 61.3 bits;  conditional E-value: 5.9e-20
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivl+avk+ng+al+y++e +k+D+eivlk vk+ng+++ ya + L+
  EFC38683.1 264 DREIVLKAVKQNGLALEYVNEIMKKDREIVLKSVKKNGKPFQYAKDTLK 312
                 9*******************************************99986 PP

  == domain 11  score: 47.0 bits;  conditional E-value: 1.7e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 DrEivl+ vkkng+ ++y+ + LknD+ ++l+Av+ n +++ y+ 
  EFC38683.1 289 DREIVLKSVKKNGKPFQYAKDTLKNDRKFILEAVQHNRDIFLYVN 333
                 9*****************************************985 PP

  == domain 12  score: 24.1 bits;  conditional E-value: 2.3e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 Dr ++leav++n  ++ y++  Lk D+ ++l+ +k+n ++l+ a
  EFC38683.1 314 DRKFILEAVQHNRDIFLYVNAILKMDRGFILQVIKKNRDVLECA 357
                 9**************************************99876 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.6   4.9   2.8e-29   2.5e-26       1     200 [.     586     809 ..     586     892 .. 0.74
   2 ?   -2.3   0.8       2.5   2.2e+03     200     222 ..     951     973 ..     897     997 .. 0.55

  Alignments for each domain:
  == domain 1  score: 92.6 bits;  conditional E-value: 2.8e-29
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHH.HHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH.......H CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrE.ikilkklkhpnivrlyevfeekdelylvleyveggeladlle.......r 91 
                 y  ++ lG+G+ G V+k++++e++  +A+K   + +++++++    +E i++lk+++    ++++++   +++ly v+e+ e ++l d+++       +
  EFC38683.1 586 YDFISILGNGAEGAVFKVLHRESRTLMAIKFKYEVEDSEEST----NEiINLLKRTDMCGKIKCFDCGMIERHLYSVMELGE-ESLSDYIQanievyrN 679
                 567789************************988777776554....4526899****9999********************9.66*****988888742 PP

                 HSS.--HH...HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH..............TT. CS
     Pkinase  92 kgs.lsee...eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl..............ke. 171
                  +s +++e   e+ +i+ qile+++ +H+++i+H Dl p+Ni     ++ K++DF  +k ++++++ t   g   Y++PEv               ++ 
  EFC38683.1 680 -SSmMTKEkliEILRIFMQILESVQSIHDHNILHGDLDPQNIVKV-GDQYKLIDFETSKVIKTGNSITIARGKFAYMSPEVShdnytddmfkrnndSKl 776
                 .332444456677799**************************999.888*********************************99888888876655115 PP

                 ....SCBSHHHHHHHHHHHHHHHHHSS-STTTS CS
     Pkinase 172 ....neyskkvDvWslGvilyelltgkppfsge 200
                      +++ ++D++slG+il++llt +p+  +e
  EFC38683.1 777 ahniGNITISCDIFSLGCILLKLLTHCPLQLDE 809
                 544467899****************99875532 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2.5
                 SSHHHHHHHHHHTHHHHHHHCTS CS
     Pkinase 200 ekgkekvekeldqlekilkilge 222
                 e++++k ++e+++l++  +il e
  EFC38683.1 951 EDENNKLNQEINKLHQRNDILME 973
                 33444445555555555555544 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9   0.2   5.2e-12   4.7e-09       4     203 ..     589     804 ..     586     823 .. 0.84

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 5.2e-12
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT...... CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk...... 95 
                   + lG+Ga G V++   +    ++++  a+K   e  ++e  e+  e ++++k+++    +k+  + + e++l+ v+e+ ++ +L+++++++      
   EFC38683.1 589 ISILGNGAEGAVFKVLHR----ESRTLMAIKFKYEVEDSE--ESTNEIINLLKRTDMCGKIKCFDCGMIERHLYSVMELGEE-SLSDYIQANievyrn 679
                  678***********9999....889999***985555544..6666778999999999999999999999********9765.9************96 PP

                  ..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.......... CS
  Pkinase_Tyr  96 ..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.......... 181
                      +k +l ++l++ +q+ + ++ +++++++H dl  +N+ ++ +++ k+ Df  ++ i   ++ ++ + a+  + +m+pE+ +++           
   EFC38683.1 680 ssMMTKEKLIEILRIFMQILESVQSIHDHNILHGDLDPQNI-VKVGDQYKLIDFETSKVI---KTGNSITIARGKFAYMSPEVSHDNYtddmfkrnnd 773
                  6544555566778899************************9.67799*************...44455567788899******999988889899999 PP

                  .........EEHHHHHHHHHHHHHHHHTTSS CS
  Pkinase_Tyr 182 .........ftsksDvWsfGvllwEiftlge 203
                           +t + D++s G +l  ++t++ 
   EFC38683.1 774 sklahnignITISCDIFSLGCILLKLLTHCP 804
                  9999999999999999999999988888765 PP

>> CBM60  Ca-dependent carbohydrate-binding module xylan-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.1   0.00012      0.11      41      89 ..      16      66 ..       5      70 .. 0.78
   2 ?   -2.2   0.0       6.2   5.6e+03      62      80 ..     112     132 ..     111     141 .. 0.72
   3 ?   -0.3   0.0       1.6   1.4e+03      50      80 ..     130     157 ..     122     170 .. 0.80
   4 ?    1.7   0.0       0.4   3.6e+02      49      82 ..     223     253 ..     212     264 .. 0.82
   5 ?    4.7   0.0     0.044        39      49      86 ..     273     307 ..     260     314 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 0.00012
       CBM60 41 tftadlt.....agahklqirylNDlyvgagqDRnLevdsitvngktvepeaas 89
                tf+ d +     +++++   +y+N + ++   DR + ++++++ngk+ +  ++ 
  EFC38683.1 16 TFKNDRDailtaVKENEFVLQYANETLKN---DREFILEAVKINGKVLQYAKEI 66
                4544444444445689999********99...***************9987765 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 6.2
       CBM60  62 yvga..gqDRnLevdsitvng 80 
                 yv++  ++DR L+++ ++ ng
  EFC38683.1 112 YVNNtlKKDRGLVLKVVKQNG 132
                 34444567****999888776 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 1.6
       CBM60  50 ahklqirylNDlyvgagqDRnLevdsitvng 80 
                 ++ +  +y+N l ++   DR +++++++ +g
  EFC38683.1 130 QNGILLQYANELLKK---DREIVLEAVKDDG 157
                 677888999999998...9999999887666 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.4
       CBM60  49 gahklqirylNDlyvgagqDRnLevdsitvngkt 82 
                 +++ l  +y+N  +++   DR +++++i+ ng +
  EFC38683.1 223 KQNGLALEYANEIMKR---DREIVLKAIQENGLA 253
                 47889999****9998...*******99988865 PP

  == domain 5  score: 4.7 bits;  conditional E-value: 0.044
       CBM60  49 gahklqirylNDlyvgagqDRnLevdsitvngktvepe 86 
                 +++ l  +y+N  +++   DR ++++s++ ngk  +  
  EFC38683.1 273 KQNGLALEYVNEIMKK---DREIVLKSVKKNGKPFQYA 307
                 4788999*****9998...************9988765 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.1   0.00023      0.21      18      59 ..     580     623 ..     574     647 .. 0.74
   2 ?    4.5   0.2     0.025        23     175     213 ..     692     734 ..     670     736 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00023
        FTA2  18 fsaekdiefleyLgkglhsiVlkvkirgk..eYALKlFrfleae 59 
                 +  +k+++f+++Lg+g+++ V+kv  r++    A+K+ +++e++
  EFC38683.1 580 KYFNKNYDFISILGNGAEGAVFKVLHRESrtLMAIKFKYEVEDS 623
                 5556899******************99987789***43333332 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.025
        FTA2 175 vsqlpkllrdlkklhklgIvvrDlkeenyi....dgkLvDlsa 213
                  +++ ++l+ ++++h + I++ Dl ++n++    + kL+D+ +
  EFC38683.1 692 LRIFMQILESVQSIHDHNILHGDLDPQNIVkvgdQYKLIDFET 734
                 578899**********************994444457888865 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       6.6   5.9e+03      18      59 ..     590     633 ..     584     639 .. 0.75
   2 !   15.7   0.0   7.7e-06    0.0069     133     249 ..     678     798 ..     652     826 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 6.6
  Kinase-like  18 ellkkgdrsvvfevkdqetgeplavkvfllps..easkkdlerl 59 
                  ++l++g +++vf+v   e    +a+k  +  +  e s +++ +l
   EFC38683.1 590 SILGNGAEGAVFKVLHRESRTLMAIKFKYEVEdsEESTNEIINL 633
                  68999999999999999988888888776655346677776554 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 7.7e-06
  Kinase-like 133 krsethkkletiarlllTlqlirlaanLqakglvhgkftvdnll.ldekgglmlggftaLvragtkvvlsevekgfaPpEllgsrgg...ytrknktk 226
                   +s+   k++ i  l + +q++  +++++++ ++hg++ ++n++    + +l+  ++++ ++ g++  ++  + ++  pE+     +   ++r+n  k
   EFC38683.1 678 RNSSMMTKEKLIEILRIFMQILESVQSIHDHNILHGDLDPQNIVkVGDQYKLIDFETSKVIKTGNSITIARGKFAYMSPEVSHDNYTddmFKRNNDSK 775
                  444444444444444555699*********************982344555555556789**********************99888899******** PP

  Kinase-like 227 mthkldaWqlGlviyriwclklP 249
                   +h++   ++   i+++ c+ l 
   EFC38683.1 776 LAHNIGNITISCDIFSLGCILLK 798
                  ******9999999*999998774 PP

>> CPT_N  Carnitine O-palmitoyltransferase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.035        31      13      41 ..      77     105 ..      76     110 .. 0.85
   2 ?    1.0   0.0      0.48   4.3e+02      14      30 ..     128     144 ..     127     155 .. 0.80
   3 ?    2.0   0.0      0.24   2.1e+02      13      30 ..     152     169 ..     149     184 .. 0.84
   4 ?   -2.4   0.0       5.6     5e+03      14      29 ..     222     237 ..     221     239 .. 0.88
   5 ?   -0.6   0.0       1.6   1.4e+03      14      40 ..     247     273 ..     244     275 .. 0.78
   6 ?    1.9   0.0      0.25   2.2e+02      13      45 ..     271     303 ..     269     305 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.035
       CPT_N  13 tvtpdGidvqlsqeaLkeiylsgvrSwkk 41 
                 +v +dG+ +++ +e+Lk+  + g+ ++k 
  EFC38683.1  77 AVKDDGLALEYANEILKHDREIGLEAVKE 105
                 5899*************988888888876 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.48
       CPT_N  14 vtpdGidvqlsqeaLke 30 
                 v ++Gi +q+ +e+Lk+
  EFC38683.1 128 VKQNGILLQYANELLKK 144
                 6789***********96 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.24
       CPT_N  13 tvtpdGidvqlsqeaLke 30 
                 +v +dG+ +++ +e Lk+
  EFC38683.1 152 AVKDDGLALEYANETLKQ 169
                 6899************97 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 5.6
       CPT_N  14 vtpdGidvqlsqeaLk 29 
                 v ++G+ +++ +e++k
  EFC38683.1 222 VKQNGLALEYANEIMK 237
                 8899********9987 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 1.6
       CPT_N  14 vtpdGidvqlsqeaLkeiylsgvrSwk 40 
                 + ++G+ +++ +e Lk+  + +++++k
  EFC38683.1 247 IQENGLALEYANETLKKDREIVLKAVK 273
                 7789***********976665555555 PP

  == domain 6  score: 1.9 bits;  conditional E-value: 0.25
       CPT_N  13 tvtpdGidvqlsqeaLkeiylsgvrSwkkrlir 45 
                 +v ++G+ +++ +e++k+  + +++S+kk  + 
  EFC38683.1 271 AVKQNGLALEYVNEIMKKDREIVLKSVKKNGKP 303
                 5889************************98665 PP

>> FapA  Flagellar Assembly Protein A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.6   1.4e+03      34      68 ..     715     749 ..     669     774 .. 0.62
   2 !   14.4  11.7   1.2e-05     0.011     331     411 ..     915     998 ..     850     999 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.6
        FapA  34 LkkagivfgidkealekilksakegeekevliAkG 68 
                 L  ++iv+  d+ +l ++ +s+  ++  +++iA+G
  EFC38683.1 715 LDPQNIVKVGDQYKLIDFETSKVIKTGNSITIARG 749
                 33333444444444444333222223444455554 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.2e-05
        FapA 331 depelkekl...keleeeleeleeeleklkkkikklpklkaekqlesekkeqlkklletkeklkeeleeleeelkelkeelesk 411
                 ++ + +++l   ++l ee+++++++ + l++kik+l++++++ ++e +k+ q + +l + +kl++e +el+e++k l+e++++ 
  EFC38683.1 915 KQYKEIKSLmsySRLLEEINKVNQRNDFLNEKIKHLEDENNKLNQEINKLHQRNDILMENNKLNQENTELQEKIKILEEQIRKL 998
                 3333333334669*************************999999************************************9875 PP

>> RNA_pol_Rpb2_45  RNA polymerase beta subunit external 1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.1    0.0028       2.5      15      45 ..      25      55 ..      16      74 .. 0.88
   2 ?    1.8   0.1      0.33     3e+02      15      43 ..     244     272 ..     233     283 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0028
                     EEHHHHTTSEEE-SSS-BETTSCBSSSEEEE CS
  RNA_pol_Rpb2_45 15 LtAdeEekyviAqAnapldeegrfveerVla 45
                     LtA +E+++v   An++l+++ +f+ e V+ 
       EFC38683.1 25 LTAVKENEFVLQYANETLKNDREFILEAVKI 55
                     9************************999875 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.33
                      EEHHHHTTSEEE-SSS-BETTSCBSSSEE CS
  RNA_pol_Rpb2_45  15 LtAdeEekyviAqAnapldeegrfveerV 43 
                      L A +E++     An++l+++ ++v + V
       EFC38683.1 244 LKAIQENGLALEYANETLKKDREIVLKAV 272
                      89*********************998777 PP

>> FlxA  FlxA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4  10.7   0.00027      0.25      15      68 ..     943     998 ..     935     999 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00027
        FlxA  15 sasqiasLqkQiknlqkqLkelses.deltkeekk.kqqqliqaQIqqlqaQIaql 68 
                  +++i+ L+ + ++l++++++l +  d l +++k  +   ++q++I++l+ QI++l
  EFC38683.1 943 LNEKIKHLEDENNKLNQEINKLHQRnDILMENNKLnQENTELQEKIKILEEQIRKL 998
                 5789********************9544444444458889*************986 PP

>> JAKMIP_CC3  JAKMIP CC3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5  11.4   0.00011       0.1     136     182 ..     925     971 ..     894     980 .. 0.81
   2 ?    1.0   3.3      0.38   3.4e+02     144     168 ..     974     998 ..     971     999 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00011
  JAKMIP_CC3 136 qdskwveekQalikrnqeLvekikkleeeeskLkqeiqdlrdqnelL 182
                 + s+ +ee  ++ +rn  L ekik+le e++kL+qei+ l + n++L
  EFC38683.1 925 SYSRLLEEINKVNQRNDFLNEKIKHLEDENNKLNQEINKLHQRNDIL 971
                 557888998888899999**************************965 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.38
  JAKMIP_CC3 144 kQalikrnqeLvekikkleeeeskL 168
                   +l ++n eL ekik+lee+  kL
  EFC38683.1 974 NNKLNQENTELQEKIKILEEQIRKL 998
                 4457788888999999999887776 PP

>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   8.1   0.00051      0.46      20      90 ..     928     997 ..     923     999 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00051
     DUF3450  20 qalkeaekavaaaaqsqkkidklddekqellaeyralkeeleslevyneqlerlvasqeqeiasleeqiee 90 
                  +l+e +k ++     ++ki++l+de ++l +e+++l+++++   ++n++l++  ++++++i+ leeqi +
  EFC38683.1 928 RLLEEINKVNQRNDFLNEKIKHLEDENNKLNQEINKLHQRNDI-LMENNKLNQENTELQEKIKILEEQIRK 997
                 577888999999999**********************988765.589999******************987 PP

>> NYD-SP28_assoc  Sperm tail C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0       1.4   1.3e+03      17      34 ..     543     560 ..     541     571 .. 0.87
   2 ?   -2.9   0.0       8.4   7.6e+03      22      30 ..     572     580 ..     562     582 .. 0.87
   3 ?    4.9   1.9     0.031        27      23      52 ..     921     957 ..     917     963 .. 0.74
   4 ?    9.0   6.4    0.0016       1.5      30      57 ..     962     989 ..     954     991 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 1.4
  NYD-SP28_assoc  17 lWdalekaLekYhevLte 34 
                     +W+  +k++++Y ++L +
      EFC38683.1 543 TWTESDKSFTDYRRILSR 560
                     79999**********975 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 8.4
  NYD-SP28_assoc  22 ekaLekYhe 30 
                      kaL++Y++
      EFC38683.1 572 FKALNRYYK 580
                     799****97 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.031
  NYD-SP28_assoc  23 kaLekYhevLteRaklieet.......esLekqNeeL 52 
                     k+L  Y ++L+e  k+ +++       ++Le +N++L
      EFC38683.1 921 KSLMSYSRLLEEINKVNQRNdflnekiKHLEDENNKL 957
                     78999**********9999955555555566666665 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.0016
  NYD-SP28_assoc  30 evLteRaklieetesLekqNeeLrnlLk 57 
                     + L++R  +++e+ +L ++N+eL++ +k
      EFC38683.1 962 NKLHQRNDILMENNKLNQENTELQEKIK 989
                     569********************98775 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  14.6     0.019        17      28     130 ..     926     992 ..     891     999 .. 0.50

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.019
      APG6_N  28 YeeflkklkkekkeeekqdeeleeleeeleklekeeeelleeLkelekereeleaelaaleeelealeeeeerfwreynelqlelleleeeldsleaqy 126
                 Y                                   ++llee++++ + ++ l+++++ le e ++l++e  ++++++n+  +e ++l++e   l+ ++
  EFC38683.1 926 Y-----------------------------------SRLLEEINKVNQRNDFLNEKIKHLEDENNKLNQE-INKLHQRNDILMENNKLNQENTELQEKI 988
                 2...................................3444444444444444444444444444444443.3344444444444444444444444443 PP

      APG6_N 127 ehaq 130
                 +  +
  EFC38683.1 989 KILE 992
                 3332 PP

>> Tropomyosin_1  Tropomyosin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       5.6     5e+03      64     106 ..     617     637 ..     606     640 .. 0.50
   2 ?    8.8  15.1     0.002       1.7       8      68 ..     932     994 ..     925     998 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 5.6
  Tropomyosin_1  64 kaeesekkktnnealtrkiqlLEeeleesdkkLkettekLret 106
                    k e +++++++ne                       ++ L+ t
     EFC38683.1 617 KYEVEDSEESTNE----------------------IINLLKRT 637
                    4444444444444......................44444444 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.002
  Tropomyosin_1   8 eaeeaqekaeeleekvKeleqenlekeqeiksLtkknqql..eeevekleeklkeakekaees 68 
                    e ++  ++ + l+ek+K+le+en + +qei++L+++n+ l  ++++++ +++l+e  + +ee+
     EFC38683.1 932 EINKVNQRNDFLNEKIKHLEDENNKLNQEINKLHQRNDILmeNNKLNQENTELQEKIKILEEQ 994
                    666777788888888888888888888888888888887632345777777777776666664 PP

>> HAUS6_N  HAUS augmin-like complex subunit 6 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.9   1.7e+03      37      54 ..     375     392 ..     373     394 .. 0.86
   2 ?    6.2   8.6    0.0075       6.7     151     223 ..     921     990 ..     904     999 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.9
     HAUS6_N  37 eivlyfLFnklDpeeakk 54 
                 + vl +L++k++pe ++k
  EFC38683.1 375 DTVLVYLLSKHNPELSRK 392
                 579**********99875 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0075
     HAUS6_N 151 ahrvslrrflrekaaadrarqkyqenaqllekkerelraeleelqaelkaekeaakkekkeasedaeeekikk 223
                 +  +s++r+l+e+++  + +  ++e+ ++le++  +l++e+ +l+++ ++     +++k+++++ +++ekik 
  EFC38683.1 921 KSLMSYSRLLEEINKVNQRNDFLNEKIKHLEDENNKLNQEINKLHQRNDILM---ENNKLNQENTELQEKIKI 990
                 66789999****999999999999*******************999888653...334444444444444443 PP

>> TRAF_BIRC3_bd  TNF receptor-associated factor BIRC3 binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.1    0.0038       3.4      14      35 ..     892     913 ..     889     921 .. 0.89
   2 ?    0.7   7.5      0.52   4.7e+02       3      59 ..     937     999 ..     935    1000 .] 0.68

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0038
  TRAF_BIRC3_bd  14 atFEnIVsVLnrEverssttie 35 
                    +t En++  Ln E+e s+++++
     EFC38683.1 892 TTLENVIKFLNGEIEISNIEMD 913
                    699**************99985 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.52
  TRAF_BIRC3_bd   3 ekklsaLetkvatFEnIVsVLnrEversstt....iea..verqrrldqekieaLekKvrqLe 59 
                    +++ + L++k++  E     Ln+E+++        +e+  +++ + + qeki+ Le+ +r+L+
     EFC38683.1 937 NQRNDFLNEKIKHLEDENNKLNQEINKLHQRndilMENnkLNQENTELQEKIKILEEQIRKLH 999
                    677777888888888888889999998875512214441134444555889999999999986 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   6.6     0.014        12      64     190 ..     862     997 ..     856     999 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.014
      AAA_11  64 NaAvDellerllrglldsegekykp.........kivRvgnee...eriseavksvsleekvekrlekeekaqlakeiskeleklakelrafeeeeeke 150
                 N  v+++l r +  +++ + +k+           ++++  n+e   ++i+ ++k+++   ++++ ++ ++  +  ++++++++ l+++++  e+e++k 
  EFC38683.1 862 NYGVNNILIRCIITMIQRDSSKRLFcysykttleNVIKFLNGEieiSNIEMDIKQYK---EIKSLMSYSRLLEEINKVNQRNDFLNEKIKHLEDENNKL 957
                 666677777744423333333333334444444488888888854444444444444...777777777788899999999999999999999999999 PP

      AAA_11 151 klkkskekskskleqerrklkkerkelskeleeaeeslee 190
                 +++ +k +++++   e++kl++e +el+++++  ee++++
  EFC38683.1 958 NQEINKLHQRNDILMENNKLNQENTELQEKIKILEEQIRK 997
                 9999999999999999999999999999999999998865 PP

>> Swi5  Swi5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   6.6   0.00098      0.88       6      49 ..     927     970 ..     914     971 .. 0.92
   2 ?    1.3   1.0      0.42   3.7e+02      22      44 ..     977     999 ..     972    1000 .] 0.47

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00098
                 HHHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHH CS
        Swi5   6 keleeqleelekelaelkeelkekkdpeetvkrhIklLheYNEi 49 
                 ++l e+++++++  + l+e+ k+ +d ++ +++ I++Lh++N+i
  EFC38683.1 927 SRLLEEINKVNQRNDFLNEKIKHLEDENNKLNQEINKLHQRNDI 970
                 66779**************************************8 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.42
                 HHHHHHHHH.HHHHHHHHHHHHH CS
        Swi5  22 lkeelkekkdpeetvkrhIklLh 44 
                 l++e  e +++ ++++++I++Lh
  EFC38683.1 977 LNQENTELQEKIKILEEQIRKLH 999
                 33333333334456666666665 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   1.2     0.056        50      21      43 ..     976     998 ..     974     999 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.056
                 HHHHHHHHHHHHHHHHHHHHHHH CS
        SlyX  21 eLndvvaeqqqqidrlqrqlrll 43 
                 +Ln++ +e q++i+ l++q+r+l
  EFC38683.1 976 KLNQENTELQEKIKILEEQIRKL 998
                 79999999999999999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1000 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2050  (0.11434); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                        91  (0.00507558); expected 17.9 (0.001)
Passed Fwd filter:                        35  (0.00195214); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 1.05u 0.30s 00:00:01.35 Elapsed: 00:00:00.48
# Mc/sec: 6247.57
//
Query:       EFC38684.1  [L=512]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0044   17.4   0.4      0.075   13.5   0.1    2.6  2  AHSP      Alpha-haemoglobin stabilising protein


Domain annotation for each model (and alignments):
>> AHSP  Alpha-haemoglobin stabilising protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0     0.036   6.5e+02      30      58 ..     322     350 ..     294     380 .. 0.75
   2 !   13.5   0.1   4.2e-06     0.075      35      62 ..     445     472 ..     437     483 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.036
        AHSP  30 eedmvvvvdDWvnlYinyykkkltGeqqe 58 
                 +e m   +d  + +Y +y+++ l  e + 
  EFC38684.1 322 KEIMIQQIDKNMAIYTKYFENDLCREINP 350
                 5667778899999******9988776655 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 4.2e-06
        AHSP  35 vvvdDWvnlYinyykkkltGeqqeqdra 62 
                 ++++DW n++iny+ k+ + +  ++ + 
  EFC38684.1 445 TLLEDWFNFFINYFGKQEMINAFQKSKH 472
                 789***********99866655555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (512 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       668  (0.0372581); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.26s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 3344.13
//
Query:       EFC38685.1  [L=525]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.2e-34  117.6   2.2    4.4e-32  111.6   2.2    2.7  1  CorA        CorA-like Mg2+ transporter protein
  ------ inclusion threshold ------
      0.012   14.9   0.2       0.02   14.2   0.2    1.3  1  MIS13       Mis12-Mtw1 protein family
      0.012   15.4   0.0      0.037   13.8   0.0    1.7  2  Ligase_CoA  CoA-ligase
      0.035   13.9   0.0       0.16   11.7   0.0    2.0  2  MotA_ExbB   MotA/TolQ/ExbB proton channel family
       0.12   12.4   1.5       0.23   11.5   0.1    2.3  2  JTB         Jumping translocation breakpoint protein (JTB)


Domain annotation for each model (and alignments):
>> CorA  CorA-like Mg2+ transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.6   2.2   1.2e-35   4.4e-32       6     292 .]     168     522 ..     163     522 .. 0.84

  Alignments for each domain:
  == domain 1  score: 111.6 bits;  conditional E-value: 1.2e-35
        CorA   6 WldlsspteeeleeLaeelgldelaledlldsee..rprvedyddylll....vlpsveldkseeeeeev..........................pls 72 
                 Wld++   +e+ ++L+  + + + ++e++  ++   + + e++d+y+++     +++v+++ ++e++                              ls
  EFC38685.1 168 WLDCQLSPNEDVDKLRSYFKFEPTTAENCYCDHFevSEKWEYFDNYFFCatsvRVKEVKQQSNNEKS--ApsikkyfwqqepeiirkpkpnlfphiYLS 264
                 7777777777777777777777777555544433113345577777775221123333333333333..34477777777777777777777777799* PP

        CorA  73 illgdnflitvrrepleal...........................devikrlkdeggkpkspgellyrlldeivdrlfellekleeeldeledel... 141
                 ill +n +it++++p   +                            ++ ++ + e +   sp+ +++ l+d+iv++l+++++ + +  d +++     
  EFC38685.1 265 ILLFENCIITFHEKPFIGFdialahlerkyarmtgrvkyvrsqdnlSAISSASSLEYSLAASPSFVFHNLMDSIVEKLIPTVDGITKSCDMIDEFAlsf 363
                 ***************88889999************99999998776555555556778999*********************************999** PP

        CorA 142 .edstkkeilrelaqlrrrlvklrralapnrevlkrllakaddkllddedkey.lrdlldelerllemlealrerleslqdtyssllser.......lN 231
                  ++++ ++ ++++a+l+r++v lr+ + p+++++  l+++ ++  + +ed +  +rd+ld+l+ + ++le   + l+  + +y + l+ +       + 
  EFC38685.1 364 sSSYQGNSVVEDIADLKRKIVVLRKLIVPKQRMFVYLVSHYLTASYFAEDVRIyMRDVLDHLTYSCDKLEMAVDALSESHTNYLTKLQIEmaqassiTD 462
                 **********************************99999999999999987755******************9*999999999999999999999*9** PP

        CorA 232 rvmkvLTvltaiflPlTlitGiyGmNfkglPelewsygypfvlllglmallailllfwfkr 292
                 ++m++L+++++i  PlTli++++GmN +  P++++   y+f +++g+m+ll++++++++++
  EFC38685.1 463 KFMNRLSSMAMIYAPLTLIGTVWGMNCQ-VPGQNEDSLYWFFGICGFMVLLVVVIVILLRK 522
                 ****************************.*****************************997 PP

>> MIS13  Mis12-Mtw1 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.2   5.6e-06      0.02     228     275 ..     412     459 ..     402     471 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 5.6e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTSTTTSSXXX CS
       MIS13 228 anveskletkvDeLqdsvhkLdsaskalnelstqklqklsrllakrsk 275
                 ++v  ++ +++D+L +s  kL++a+ al+e  t++l kl++++a+ s+
  EFC38685.1 412 EDVRIYMRDVLDHLTYSCDKLEMAVDALSESHTNYLTKLQIEMAQASS 459
                 67888999*********************************9998765 PP

>> Ligase_CoA  CoA-ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0     1e-05     0.037      29      56 ..      23      50 ..      11      58 .. 0.89
   2 ?   -2.8   0.0       1.4   5.1e+03       3      22 ..     106     125 ..     105     138 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1e-05
                ....T--BSEEEE-TSS--......... CS
  Ligase_CoA 29 knvlgseqheiidlGddaftkGrpHPmi 56
                 +++++++ e+id G+d  t+G  HPm+
  EFC38685.1 23 YYTNTTDEEEMIDHGNDISTVGTHHPMV 50
                5678999********************8 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.4
                 SSHHHHHHHHHHHHHT.... CS
  Ligase_CoA   3 nGGtLayeamdlikealgdv 22 
                 +G+tL+    d+i++ +g+ 
  EFC38685.1 106 SGATLSRKESDVISQVSGTR 125
                 68899999889988886554 PP

>> MotA_ExbB  MotA/TolQ/ExbB proton channel family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.51   1.8e+03     103     122 ..     324     343 ..     322     349 .. 0.76
   2 ?   11.7   0.0   4.5e-05      0.16      28      68 ..     447     487 ..     423     489 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.51
                 HHHHHHHHHHHHHHHHHHHH CS
   MotA_ExbB 103 vAipavlaynklkrkverlv 122
                 +A p+ +++n++ + ve+l+
  EFC38685.1 324 AASPSFVFHNLMDSIVEKLI 343
                 67888899999988888876 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 4.5e-05
                 HHHHHHHHHHHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHH CS
   MotA_ExbB  28 rraleealsreeerlekglsilatigslaPllGLlGTVlGl 68 
                    l+ +++++ +  +k ++ l++++ +   l L+GTV+G+
  EFC38685.1 447 LTKLQIEMAQASSITDKFMNRLSSMAMIYAPLTLIGTVWGM 487
                 455788888888999999999**9999988899*******9 PP

>> JTB  Jumping translocation breakpoint protein (JTB)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.3      0.84     3e+03      23      34 ..     195     205 ..     175     246 .. 0.62
   2 ?   11.5   0.1   6.4e-05      0.23      61      98 ..     488     525 .]     428     525 .] 0.93

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.84
         JTB  23 eCkpCsefeika 34 
                 +C  C +fe+  
  EFC38685.1 195 NCY-CDHFEVSE 205
                 443.44444443 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 6.4e-05
         JTB  61 sCdrvalleerefwkFeilmlvlavlsavlvvlRkrvL 98 
                  C+   ++e+  +w F i+ +++ ++ +++++lRk++L
  EFC38685.1 488 NCQVPGQNEDSLYWFFGICGFMVLLVVVIVILLRKKIL 525
                 5999999****************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (525 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       969  (0.0540465); expected 358.6 (0.02)
Passed bias filter:                      662  (0.0369234); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.42
# Mc/sec: 3716.73
//
Query:       EFC38686.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.04   14.0   0.2       0.79    9.9   0.1    2.4  2  HECW1_helix  Helical box domain of E3 ubiquitin-protein ligas
      0.063   13.3   4.6       0.39   10.7   0.4    3.1  2  DUF2116      Uncharacterized protein containing a Zn-ribbon (
      0.069   12.4  23.3      0.092   12.0   8.3    2.8  3  MASE4        Membrane-associated sensor, integral membrane do
       0.18   11.7   1.2        4.5    7.2   0.5    2.8  2  SLATT_1      SMODS and SLOG-associating 2TM effector domain 1
        1.4    7.5  20.3        2.1    6.9  20.3    1.3  1  EMP70        Endomembrane protein 70


Domain annotation for each model (and alignments):
>> HECW1_helix  Helical box domain of E3 ubiquitin-protein ligase HECW1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.1   0.00022      0.79      39      64 ..     256     281 ..     245     282 .. 0.93
   2 ?    1.4   0.0       0.1   3.6e+02       9      25 ..     315     332 ..     307     336 .] 0.74

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00022
  HECW1_helix  39 mvskirrdpekferYqhnrdlVallN 64 
                  +v  ir+++ ++ + qh+  lVa++N
   EFC38686.1 256 LVYVIRKNSLNTSQVQHKNSLVAFMN 281
                  6888*********************9 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.1
  HECW1_helix   9 kfitrPdfl.svlhsnqe 25 
                  k++t+Pd+  svl++n+e
   EFC38686.1 315 KLVTSPDNSqSVLSNNNE 332
                  799****65167777765 PP

>> DUF2116  Uncharacterized protein containing a Zn-ribbon (DUF2116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.4   0.00011      0.39      28      52 ..      80     104 ..      76     111 .. 0.83
   2 ?    2.6   0.3     0.037   1.3e+02      36      58 ..     183     205 ..     176     206 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00011
     DUF2116  28 yekkrkkvarsqqilfgililllav 52 
                 + k++ k++r q+ilfg+++ ++  
  EFC38686.1  80 LVKAKDKMMRNQKILFGVMLSFVFT 104
                 568999*************998764 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.037
     DUF2116  36 arsqqilfgililllavvlvlkf 58 
                 +++   lf i++++ a+ ++l++
  EFC38686.1 183 RKTSTALFWIVMVITAIAMFLAI 205
                 56777789999999999999975 PP

>> MASE4  Membrane-associated sensor, integral membrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   4.0   0.00038       1.4      86     174 ..      66     149 ..      38     153 .. 0.83
   2 ?   12.0   8.3   2.6e-05     0.092      86     164 ..     161     240 ..     147     258 .. 0.79
   3 ?   -1.2   1.4      0.27   9.8e+02     111     172 ..     245     305 ..     230     316 .. 0.61

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00038
       MASE4  86 sfavlillalllykkrksklesrknkilllliillfllallllahllSshseeltldiidnktenfsalwssgilllLialwlvallll 174
                 +++ +i++a+ ++   k k +  +n+++l+ ++l+f+++  ++a ++   ++++ l++  n    +s++ +++++  L ++w++a+l  
  EFC38686.1  66 LIIYSIITAITVHFLVKAKDKMMRNQKILFGVMLSFVFTH-AIALFFRLIYNSTGLHVNLN----YSNIDKETVIGNLKLMWATAFLEN 149
                 4567788888888888888878889999999888888887.77888899999999999887....999999999999999999998765 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 2.6e-05
       MASE4  86 sfavlillalllykkrksklesrknkilllliillfllallllahllSshseeltldiidnk.tenfsalwssgilllLi 164
                  f+++++l ++l++ +k  +  rk+ + l++i+++++++ ++la  lS  + +++l ++ ++   + ++++ s  +l+L 
  EFC38686.1 161 CFLMSFILTIFLQTVEKAGAMGRKTSTALFWIVMVITAIAMFLAIALSVSNGTVNLLLKIQEiRFDVTPIYLSLFVLYLS 240
                 6999***************************************************9997663134555555555444444 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.27
       MASE4 111 killlliillfllal.lllahllSshseeltldiidnktenfsalwssgilllLialwlvall 172
                 +i+++l + + l+ +    + ++S+ +++ +l   +n  + ++ ++  ++++lL+ l++v+ +
  EFC38686.1 245 EIVIFLASGIRLVYViRKNSLNTSQVQHKNSLVAFMN--RPYTKIVGLITGILLCQLFAVLSI 305
                 4555555555555553344555555555555555555..667777777777777777666655 PP

>> SLATT_1  SMODS and SLOG-associating 2TM effector domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0     0.075   2.7e+02      41      77 ..      22      58 ..      18      62 .. 0.87
   2 ?    7.2   0.5    0.0013       4.5      21      52 ..     183     214 ..     176     221 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.075
     SLATT_1 41 laalrafgelsvdlvgvlaavaaallaWlelkqyeel 77
                la +  f+ l++d++ +++a ++a+  + +l q ++ 
  EFC38686.1 22 LASFDFFSPLEIDFTNLTVAEITAGSRFPQLVQNSTS 58
                688889999******************9999887765 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0013
     SLATT_1  21 eraakrwrlllillellalllaalrafgelsv 52 
                 +++++++++++++++++a++la++  +++ +v
  EFC38686.1 183 RKTSTALFWIVMVITAIAMFLAIALSVSNGTV 214
                 678899****************9987777666 PP

>> EMP70  Endomembrane protein 70
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9  20.3   0.00058       2.1     276     443 ..      65     261 ..      42     306 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00058
       EMP70 276 lmalvtllla.llgfls.....psnrgslltvalllyvllgliaGYvsarl......................yktfggekwkkntlltalllpgllfl 346
                 ++++ ++++a +++fl        +++++l  ++l +v++  ia ++   +                       k +  +    n++ +  ++p+ +fl
  EFC38686.1  65 FLIIYSIITAiTVHFLVkakdkMMRNQKILFGVMLSFVFTHAIALFFRLIYnstglhvnlnysnidketvignLKLMWATAFLENVISFLQMIPFSCFL 163
                 4444444433144555422222334445555566667777777776666556666666666666665555555444444566666************** PP

       EMP70 347 vffllnlilwakessgalpfgtlvlllllwflisvPlvliGsllgfkkkaiehpvrtnqiprqipkqpwylkpl...lsvllgGilpFgaifielyfil 442
                 + f+l ++l + e+ ga+  +t ++l+ + ++i+   +++   l+  + +++   ++++i  ++   p+yl+ +   ls++ + i+ F a  i l++++
  EFC38686.1 164 MSFILTIFLQTVEKAGAMGRKTSTALFWIVMVITAIAMFLAIALSVSNGTVNLLLKIQEIRFDVT--PIYLSLFvlyLSIIATEIVIFLASGIRLVYVI 260
                 ***********************************************8788********998888..57777654447889999******999999997 PP

       EMP70 443 s 443
                 +
  EFC38686.1 261 R 261
                 5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1375  (0.0766914); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 1992.21
//
Query:       EFC38687.1  [L=389]
Description: leucine rich repeat protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.3e-47  154.6  20.2    6.7e-06   25.7   0.0   11.7 12  LRR_6         Leucine Rich repeat
    4.3e-29  100.1   9.4    1.6e-07   31.0   0.5    4.8  4  LRR_8         Leucine rich repeat
    2.5e-24   84.9  14.2    0.00015   22.1   0.1    7.8 11  LRR_4         Leucine Rich repeats (2 copies)
    2.1e-15   54.9   9.5       0.57   10.9   0.0   10.9 11  LRR_1         Leucine Rich Repeat
    8.1e-09   35.2   0.1    0.00012   21.7   0.0    3.6  3  LRR_9         Leucine-rich repeat
    8.7e-08   31.9   0.0    1.9e-07   30.9   0.0    1.5  1  F-box-like    F-box-like
    2.3e-05   24.1   0.2    6.9e-05   22.6   0.2    1.8  1  F-box         F-box domain
  ------ inclusion threshold ------
       0.14   11.8   0.2       0.31   10.7   0.2    1.5  1  DUF5537       Family of unknown function (DUF5537)
       0.71    9.9   2.0         29    4.8   0.1    3.4  4  RelB_leu_zip  RelB leucine zipper


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.34   6.8e+02       5      17 ..      99     111 ..      98     112 .. 0.89
   2 !    8.8   0.1   0.00091       1.8       5      23 ..     121     139 ..     118     140 .. 0.91
   3 !   14.2   0.2   1.7e-05     0.033       3      23 ..     143     163 ..     141     164 .. 0.90
   4 ?   -1.1   0.0       1.4   2.8e+03       5      21 ..     169     185 ..     167     188 .. 0.74
   5 !   18.3   0.0   8.3e-07    0.0016       3      23 ..     191     211 ..     189     212 .. 0.92
   6 !   13.0   0.0   4.2e-05     0.083       4      24 .]     216     236 ..     214     236 .. 0.91
   7 !   17.7   0.0   1.3e-06    0.0025       4      24 .]     240     260 ..     237     260 .. 0.92
   8 !   11.5   0.1   0.00012      0.24       2      23 ..     262     283 ..     261     284 .. 0.88
   9 !    9.8   0.0   0.00043      0.85       4      23 ..     288     307 ..     285     308 .. 0.88
  10 !   25.7   0.0   3.4e-09   6.7e-06       3      24 .]     311     332 ..     309     332 .. 0.93
  11 !   17.6   0.0   1.4e-06    0.0028       3      24 .]     335     356 ..     333     356 .. 0.93
  12 !   20.0   0.0   2.4e-07   0.00048       4      23 ..     360     379 ..     357     379 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.34
       LRR_6   5 LteLdLsgNdIgD 17 
                 L+++d+ ++ Ig+
  EFC38687.1  99 LRSVDIGYCYIGN 111
                 99*******9987 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00091
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+Ld+  N+++ +G++ +
  EFC38687.1 121 LTSLDIDNNCVDEQGVKLI 139
                 9***************987 PP

  == domain 3  score: 14.2 bits;  conditional E-value: 1.7e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt L++ +N Ig eG +++
  EFC38687.1 143 HNLTRLNIGCNRIGLEGFKSI 163
                 79***************8887 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 1.4
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 ++ L++s+ + g eGa+
  EFC38687.1 169 MRDLNVSSSGAGVEGAK 185
                 57899998777777776 PP

  == domain 5  score: 18.3 bits;  conditional E-value: 8.3e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  hLt+ ++sgN+Ig eGa+++
  EFC38687.1 191 KHLTKFNISGNEIGEEGAKSI 211
                 6******************98 PP

  == domain 6  score: 13.0 bits;  conditional E-value: 4.2e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt Ld+ +N+Ig eGa++++
  EFC38687.1 216 WLTMLDICSNQIGAEGAKSIS 236
                 6899**************996 PP

  == domain 7  score: 17.7 bits;  conditional E-value: 1.3e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt+L +sgN+Ig eGa++++
  EFC38687.1 240 RLTKLYISGNGIGPEGAQSIS 260
                 59****************996 PP

  == domain 8  score: 11.5 bits;  conditional E-value: 0.00012
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                  +hLt+L + gN+Ig +G +++
  EFC38687.1 262 LSHLTTLFIGGNQIGSKGSKSI 283
                 58***************97766 PP

  == domain 9  score: 9.8 bits;  conditional E-value: 0.00043
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L + +N+Ig eGa ++
  EFC38687.1 288 RLTILYIDSNEIGSEGANSI 307
                 69**************9776 PP

  == domain 10  score: 25.7 bits;  conditional E-value: 3.4e-09
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L+eL +s+N+IgDeGa++++
  EFC38687.1 311 SNLKELYISDNQIGDEGAKSIS 332
                 89*****************996 PP

  == domain 11  score: 17.6 bits;  conditional E-value: 1.4e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  hLt+L++  N+IgD+Ga++++
  EFC38687.1 335 KHLTTLEILRNEIGDQGAKSIS 356
                 6******************996 PP

  == domain 12  score: 20.0 bits;  conditional E-value: 2.4e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L++s+N IgD+Ga+ L
  EFC38687.1 360 QLTRLHISCNRIGDQGAKLL 379
                 59***************976 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.1   9.7e-08   0.00019       2      58 ..     120     176 ..     113     178 .. 0.96
   2 !   27.6   0.0     9e-10   1.8e-06       2      61 .]     192     251 ..     187     251 .. 0.98
   3 !   22.7   0.1     3e-08   5.9e-05      20      61 .]     258     299 ..     255     299 .. 0.94
   4 !   31.0   0.5   8.2e-11   1.6e-07       1      61 []     311     371 ..     311     371 .. 0.98

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 9.7e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +LtsLd++nN   + + +    l+nL+ L++++N++     +++sg+++ r L++s+
  EFC38687.1 120 QLTSLDIDNNCVDEQGVKLIGELHNLTRLNIGCNRIGLEGFKSISGMKQMRDLNVSS 176
                 7**********************************9998889************986 PP

  == domain 2  score: 27.6 bits;  conditional E-value: 9e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+ ++s N + + + ++   l+ L++Ld+ +N++    ++++s+L++L++L++sgN +
  EFC38687.1 192 HLTKFNISGNEIGEEGAKSIGELKWLTMLDICSNQIGAEGAKSISQLERLTKLYISGNGI 251
                 8*********************************************************86 PP

  == domain 3  score: 22.7 bits;  conditional E-value: 3e-08
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + ++ls+L++L ++ N++ +   +++s+L++L+ L++++N +
  EFC38687.1 258 SISQLSHLTTLFIGGNQIGSKGSKSISQLKRLTILYIDSNEI 299
                 6789************************************87 PP

  == domain 4  score: 31.0 bits;  conditional E-value: 8.2e-11
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nL++L++s+N++ + + ++ ++l++L++L++ +N++    ++++s+L++L+ L++s Nr+
  EFC38687.1 311 SNLKELYISDNQIGDEGAKSISQLKHLTTLEILRNEIGDQGAKSISQLKQLTRLHISCNRI 371
                 69*******************************************************9997 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       1.3   2.5e+03      21      36 ..      95     109 ..      67     117 .. 0.68
   2 !   11.0   0.0   0.00024      0.47       2      36 ..      98     131 ..      97     137 .. 0.81
   3 !   20.1   0.9   3.1e-07   0.00061       1      40 [.     119     158 ..     119     162 .. 0.86
   4 !   10.7   0.1   0.00028      0.56       2      32 ..     144     176 ..     143     178 .. 0.84
   5 ?    5.4   0.0     0.013        26      21      36 ..     189     203 ..     181     216 .. 0.81
   6 !   12.0   0.0   0.00011      0.21       1      36 [.     191     227 ..     191     239 .. 0.85
   7 !   14.3   0.0   2.1e-05     0.042       3      36 ..     217     251 ..     215     263 .. 0.86
   8 !   15.5   0.0   8.6e-06     0.017       2      37 ..     240     276 ..     239     282 .. 0.82
   9 !   15.5   0.1   8.5e-06     0.017       2      36 ..     264     299 ..     263     310 .. 0.83
  10 !   22.1   0.1   7.6e-08   0.00015       2      36 ..     312     347 ..     311     352 .. 0.87
  11 !   13.4   0.2   3.9e-05     0.078       1      38 [.     335     373 ..     335     379 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.3
                 H-TT--EEE-.-S--- CS
       LRR_4  21 klpnLkeLdLsgNnli 36 
                 + ++L+++d+  + +i
  EFC38687.1  95 SYDQLRSVDIGYC-YI 109
                 4566888888555.55 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00024
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnli 36 
                 +L+++d++ + +   + ++ +++L++Ld+ +Nn +
  EFC38687.1  98 QLRSVDIGYCYIGNSQTISEMKQLTSLDI-DNNCV 131
                 68999999999997777666*********.66655 PP

  == domain 3  score: 20.1 bits;  conditional E-value: 3.1e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdld 40 
                 ++L++Ld+ nN++ + +  l + l nL+ L++ g+n+i  l+
  EFC38687.1 119 KQLTSLDIDNNCVDEQGVkLIGeLHNLTRLNI-GCNRI-GLE 158
                 58************999997766*********.99999.555 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00028
                 S--EEE--SS---E-S-HH...H-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdiplle...klpnLkeLdLsg 32 
                 nL+ L+++ N++  +++++   ++++++ L++s+
  EFC38687.1 144 NLTRLNIGCNRIG-LEGFKsisGMKQMRDLNVSS 176
                 9*******99*99.888666647********975 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.013
                 H-TT--EEE-.-S--- CS
       LRR_4  21 klpnLkeLdLsgNnli 36 
                 +l++L+++++sgN  i
  EFC38687.1 189 QLKHLTKFNISGN-EI 203
                 4999999999999.43 PP

  == domain 6  score: 12.0 bits;  conditional E-value: 0.00011
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++ ++s+N + + +   ++ l+ L+ Ld+ +N +i
  EFC38687.1 191 KHLTKFNISGNEIGEEGAksIGELKWLTMLDICSN-QI 227
                 68************988885446********9777.77 PP

  == domain 7  score: 14.3 bits;  conditional E-value: 2.1e-05
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 L+ Ld+ +Nq+   +   +++l  L++L++sgN  i
  EFC38687.1 217 LTMLDICSNQIGAEGAksISQLERLTKLYISGN-GI 251
                 99**********877786667***********9.44 PP

  == domain 8  score: 15.5 bits;  conditional E-value: 8.6e-06
                 S--EEE--SS---.E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqlt.dipl..leklpnLkeLdLsgNnlit 37 
                 +L++L++s+N +  + +   +++l +L++L + gN +i+
  EFC38687.1 240 RLTKLYISGNGIGpE-GAqsISQLSHLTTLFIGGN-QIG 276
                 7************44.4455557*********778.885 PP

  == domain 9  score: 15.5 bits;  conditional E-value: 8.5e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L +++Nq+ + ++  +++l+ L+ L++ +N  i
  EFC38687.1 264 HLTTLFIGGNQIGSKGSksISQLKRLTILYIDSN-EI 299
                 7************866676557*********777.55 PP

  == domain 10  score: 22.1 bits;  conditional E-value: 7.6e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 nL++L++s+Nq+ d +   +++l++L++L + +N  i
  EFC38687.1 312 NLKELYISDNQIGDEGAksISQLKHLTTLEILRN-EI 347
                 9*************99987667********9899.54 PP

  == domain 11  score: 13.4 bits;  conditional E-value: 3.9e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L +  N + d +   +++l++L+ L++ ++n+i+d
  EFC38687.1 335 KHLTTLEILRNEIGDQGAksISQLKQLTRLHI-SCNRIGD 373
                 589******9*****99987667*********.7669876 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0      0.13   2.5e+02       1      13 [.      98     110 ..      98     117 .. 0.81
   2 ?    4.8   0.0     0.029        58       1      12 [.     120     131 ..     120     142 .. 0.82
   3 ?    4.9   0.1     0.028        56       1      15 [.     144     158 ..     144     166 .. 0.75
   4 ?    4.2   0.0     0.046        92       3      21 ..     191     212 ..     189     214 .. 0.71
   5 ?    1.5   0.0      0.35     7e+02       2      21 ..     217     236 ..     216     238 .. 0.77
   6 ?    4.7   0.0     0.032        64       1      20 [.     240     259 ..     240     262 .. 0.76
   7 ?    5.1   0.0     0.024        48       1      23 []     264     286 ..     264     286 .. 0.90
   8 ?    6.2   0.0      0.01        20       1      23 []     288     310 ..     288     310 .. 0.91
   9 !   10.9   0.0   0.00028      0.57       1      22 [.     312     333 ..     312     337 .. 0.90
  10 ?   -0.6   0.0       1.8   3.5e+03       1      21 [.     336     356 ..     333     358 .. 0.68
  11 ?    2.2   0.1      0.21   4.1e+02       1      14 [.     360     373 ..     360     382 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.13
       LRR_1   1 nLrhLdLsnnpll 13 
                 +Lr+ d++++ ++
  EFC38687.1  98 QLRSVDIGYCYIG 110
                 59********983 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.029
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++Ld+ nn+ 
  EFC38687.1 120 QLTSLDIDNNCV 131
                 599*******95 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.028
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL++L+++ n+++  
  EFC38687.1 144 NLTRLNIGCNRIGLE 158
                 8******99998444 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.046
       LRR_1   3 rhL...dLsnnpllglppnsfq 21 
                 +hL   ++s+n ++  ++ s+ 
  EFC38687.1 191 KHLtkfNISGNEIGEEGAKSIG 212
                 555555******9887777775 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.35
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ Ld+++n+++  ++ s++
  EFC38687.1 217 LTMLDICSNQIGAEGAKSIS 236
                 6779*****99777777765 PP

  == domain 6  score: 4.7 bits;  conditional E-value: 0.032
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++s+n ++  +++s+
  EFC38687.1 240 RLTKLYISGNGIGPEGAQSI 259
                 699*******9966666655 PP

  == domain 7  score: 5.1 bits;  conditional E-value: 0.024
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++L +++n+++++++ s++ L
  EFC38687.1 264 HLTTLFIGGNQIGSKGSKSISQL 286
                 699**************999865 PP

  == domain 8  score: 6.2 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L+ L++ +n +++ ++ns++ L
  EFC38687.1 288 RLTILYIDSNEIGSEGANSISQL 310
                 699****************9865 PP

  == domain 9  score: 10.9 bits;  conditional E-value: 0.00028
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++L++s+n++++ ++ s++ 
  EFC38687.1 312 NLKELYISDNQIGDEGAKSISQ 333
                 8***********9999999875 PP

  == domain 10  score: -0.6 bits;  conditional E-value: 1.8
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L + +n +++ ++ s++
  EFC38687.1 336 HLTTLEILRNEIGDQGAKSIS 356
                 477778877777677777665 PP

  == domain 11  score: 2.2 bits;  conditional E-value: 0.21
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++L++s n++++
  EFC38687.1 360 QLTRLHISCNRIGD 373
                 599*******9855 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.1     0.004       7.9      36     113 ..      91     170 ..      68     179 .. 0.77
   2 ?    2.1   0.0     0.062   1.2e+02      59     101 ..     234     276 ..     214     281 .. 0.76
   3 !   21.7   0.0   5.9e-08   0.00012      61     129 ..     284     351 ..     278     374 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.004
       LRR_9  36 nlGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelq..eladldPlaslk 113
                 ++  + dq+ ++d+    i + + +  +k+l +l ++nn +   + +l   l nl+ l +  n++    +  +  + +++
  EFC38687.1  91 EILKSYDQLRSVDIGYCYIGNSQTISEMKQLTSLDIDNNCVDEQGVKLIGELHNLTRLNIGCNRIGleGFKSISGMKQMR 170
                 55568899999***********************************************9999986400344444444444 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.062
       LRR_9  59 gfPllkrlktlllnnnrivriaegleevlPnleelvltnnelq 101
                 ++  l+rl  l+++ n i   + +    l +l++l + +n++ 
  EFC38687.1 234 SISQLERLTKLYISGNGIGPEGAQSISQLSHLTTLFIGGNQIG 276
                 5667899999999999998888877788888899988888876 PP

  == domain 3  score: 21.7 bits;  conditional E-value: 5.9e-08
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                   lkrl +l++++n i   + +    l nl+el +++n++ + +  + + +lk+l++l +l+n + ++ 
  EFC38687.1 284 SQLKRLTILYIDSNEIGSEGANSISQLSNLKELYISDNQIGDEGA-KSISQLKHLTTLEILRNEIGDQG 351
                 579****************9999999****************998.99***************998765 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   0.0   9.4e-11   1.9e-07       3      37 ..       7      42 ..       6      44 .. 0.92

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 9.4e-11
  F-box-like  3 rLPdEiLlqIFsyLppsdLlr.lalVCrrWrrvald 37
                +LP+EiL++IF++L+ s  ++ ++l +++W+ ++++
  EFC38687.1  7 SLPNEILIEIFQFLESSFVVNsCMLISKKWYKIIFN 42
                8*************99988888***********975 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.2   3.5e-08   6.9e-05       5      39 ..       7      42 ..       6      50 .. 0.92

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 3.5e-08
                HS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTT CS
       F-box  5 rLPsevlrhILerLplsd.llalrrVSkgwrilids 39
                +LP+e+l +I+++L+ s  + ++++ Sk+w+++i +
  EFC38687.1  7 SLPNEILIEIFQFLESSFvVNSCMLISKKWYKIIFN 42
                69******************************9965 PP

>> DUF5537  Family of unknown function (DUF5537)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.2   0.00016      0.31       5      83 ..       9      89 ..       6     101 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00016
     DUF5537  5 speikfetskvtrssl..dscllfesswkkavletqkikkeyttafgleelkeclkmpylpelqscskslsssplevpkrl 83
                  ei +e  ++  ss+  +sc+l+   w k +++  k      t    e++   +k p+l ++  ++       le  k l
  EFC38687.1  9 PNEILIEIFQFLESSFvvNSCMLISKKWYKIIFNQVKTLSCELTFHDQEKIDRLVKSPWLHNISKIKLRACDDYLESIKGL 89
                579999999**999975589**************999988788888999999********999777666666666666655 PP

>> RelB_leu_zip  RelB leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0         3     6e+03      43      58 ..     152     167 ..     149     187 .. 0.74
   2 ?    4.8   0.1     0.014        29      31      55 ..     236     260 ..     229     278 .. 0.75
   3 ?    0.7   0.1      0.27   5.5e+02      30      54 ..     283     307 ..     266     316 .. 0.74
   4 ?    2.2   0.1     0.092   1.8e+02      29      55 ..     306     332 ..     293     357 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 3
  RelB_leu_zip  43 engfgLeGaqaglgeg 58 
                    n  gLeG ++ +g +
    EFC38687.1 152 CNRIGLEGFKSISGMK 167
                   5778888888877754 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.014
  RelB_leu_zip  31 sRtteiideYikengfgLeGaqagl 55 
                   s   ++ + Yi  ng g eGaq+ +
    EFC38687.1 236 SQLERLTKLYISGNGIGPEGAQSIS 260
                   555667788*************965 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.27
  RelB_leu_zip  30 vsRtteiideYikengfgLeGaqag 54 
                   +s   ++   Yi+ n  g eGa++ 
    EFC38687.1 283 ISQLKRLTILYIDSNEIGSEGANSI 307
                   55555555569999*9999999985 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.092
  RelB_leu_zip  29 avsRtteiideYikengfgLeGaqagl 55 
                   ++s  +++ + Yi +n  g eGa++ +
    EFC38687.1 306 SISQLSNLKELYISDNQIGDEGAKSIS 332
                   567777777789999999999998754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       456  (0.0254337); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2437.22
//
Query:       EFC38688.1  [L=539]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (539 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       810  (0.0451782); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.26s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 3528.80
//
Query:       EFC38689.1  [L=376]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.7e-51  175.5   5.1    2.4e-51  175.0   5.1    1.2  1  G-alpha    G-protein alpha subunit
    3.1e-10   39.8   0.0    6.1e-06   25.8   0.0    2.5  2  Arf        ADP-ribosylation factor family
    0.00061   19.5   0.0     0.0017   18.1   0.0    1.6  2  AAA_29     P-loop containing region of AAA domain
    0.00063   19.2   0.0      0.021   14.3   0.0    2.3  2  SRPRB      Signal recognition particle receptor beta subunit
     0.0015   19.1   0.0     0.0053   17.3   0.0    1.8  1  AAA_23     AAA domain
     0.0034   17.4   0.0          1    9.5   0.0    2.5  2  MMR_HSR1   50S ribosome-binding GTPase
     0.0035   17.9   0.1     0.0083   16.6   0.1    1.9  1  ABC_tran   ABC transporter
  ------ inclusion threshold ------
      0.011   15.7   0.1      0.038   13.9   0.0    2.0  3  ATPase_2   ATPase domain predominantly from Archaea
      0.095   12.9   0.0          2    8.6   0.0    2.6  2  Roc        Ras of Complex, Roc, domain of DAPkinase
       0.15   11.4   2.1         20    4.5   0.1    3.3  4  Gtr1_RagA  Gtr1/RagA G protein conserved region


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  175.0   5.1   1.4e-54   2.4e-51       8     350 ..       6     325 ..       2     328 .. 0.79

  Alignments for each domain:
  == domain 1  score: 175.0 bits;  conditional E-value: 1.4e-54
                 XXXXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS----HH.HHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HC CS
     G-alpha   8 dkslkaerkarkkkrevkllllGqseSGKsTilkqlkllykkgfsee.elatwraviqlnivrsiktilealesleselsesfelqelkerldplkkve 105
                 ++++++ ++++++    k+l+lG s+SGKsT++  lkl+  + ++ + + ++   ++ + +   i+ i ea+ ++e ++     l++l  +l  +++  
  EFC38689.1   6 NNNIQQASTRKRE----KVLILGPSDSGKSTLFHMLKLITSG-HDVDaKFENNLRIVSSWV---IERIWEAMGEQERNH-----LKDLIPELRSVFENT 91 
                 4555566666666....********************88855.444402344334444444...568999999954444.....455555555554444 PP

                 HHHH..........HHCCHHC-HCHHHHHHHHCCSHHHHHHHC...CGCCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-T CS
     G-alpha 106 asliaklssateeeqeiefnpraevgedikaLwndpgiqelye...rrnkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdsk 201
                 ++           +  +e+++r + +e +++Lw+ p+++e+ye   +r+ i++ +n++ + +++e   ++++ p    ++++r  t+Gi  ++  ++++
  EFC38689.1  92 EDA----------NLATELQNRDDCCEILVTLWKIPFFREFYEsvwSRDGISMFENVKELVSRIE--HKKSFSP--YSLVHCR--TTGILSYET-MGKN 173
                 443..........3677777788********************8887778888899999977777..5669999..999***9..********9.888* PP

                 EEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS.-GGG.....C CS
     G-alpha 202 lefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg.klsk.....y 294
                 +e++++dvgG+r+erkkW+++f+d+ ++i++vslsef+q+l+ed+++ r++esl+l +e++n++++   + i+++ K+Dil +Kl++g k        +
  EFC38689.1 174 TEIEVIDVGGRRNERKKWIHCFEDTHTLIYMVSLSEFNQTLIEDNSTRRMDESLSLISEVMNSRWFVGLRKIILFVKPDILCKKLENGvKYGGelnpnI 272
                 *************************************************************************************88876655422345 PP

                 CTT--.H.CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHH CS
     G-alpha 295 fpsye.grkndlesvlkylrnkFeeihkeksnnrrkiythftsatdtkevqkviesv 350
                  p+ +   ++ l+ v++ ++ +F + + + +       +h+++ t ++++++v e +
  EFC38689.1 273 LPELDrIADHYLKLVINSIITEFFKKIDRTT----IDSYHIVNNTSEDDIKSVCEMI 325
                 6666653456689999999988877765432....346899***********99877 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.0   8.7e-05      0.16       9      36 ..      12      39 ..       5      74 .. 0.86
   2 !   25.8   0.0   3.4e-09   6.1e-06      45      95 ..     161     211 ..     148     270 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 8.7e-05
                TT.TTEEEEEEEESTTSSHHHHHHHHHH CS
         Arf  9 klkkkelrilllGLDnaGKtTilkklkl 36
                 +++k  ++l+lG   +GK+T+ ++lkl
  EFC38689.1 12 ASTRKREKVLILGPSDSGKSTLFHMLKL 39
                4458999*******************96 PP

  == domain 2  score: 25.8 bits;  conditional E-value: 3.4e-09
                 SSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT CS
         Arf  45 TigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre 95 
                 T+g  + e + kn +++v DvGG+++ R+ W + fe+t+++i++v  ++ +
  EFC38689.1 161 TTGILSYETMGKNTEIEVIDVGGRRNERKKWIHCFEDTHTLIYMVSLSEFN 211
                 67777778888*********************************9876543 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   9.3e-07    0.0017      15      40 ..      10      35 ..       5      51 .. 0.75
   2 ?   -4.0   0.0       7.2   1.3e+04      26      39 ..     324     337 ..     317     337 .. 0.78

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 9.3e-07
      AAA_29 15 htieidlkgatlltGpsGsGKSTllD 40
                ++++ + ++ +l+ Gps sGKSTl+ 
  EFC38689.1 10 QQASTRKREKVLILGPSDSGKSTLFH 35
                5666676778**************84 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 7.2
      AAA_29  26 lltGpsGsGKSTll 39 
                 ++ G+  + K+T++
  EFC38689.1 324 MIFGERSAQKTTFI 337
                 78899999999986 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   1.2e-05     0.021       2      25 ..      16      39 ..      15      58 .. 0.83
   2 ?    2.5   0.0     0.047        85      45      88 ..     170     210 ..     146     218 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.2e-05
                ---EEEEE-STTSSHHHHHHHHHH CS
       SRPRB  2 skpavllvGlsdsGKTslftrLtt 25
                ++++vl++G+sdsGK +lf+ L  
  EFC38689.1 16 KREKVLILGPSDSGKSTLFHMLKL 39
                5789****************9865 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.047
                 ..GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS- CS
       SRPRB  45 sekgskltliDfPGheklrqklleklkaksslkglvfvvDStid 88 
                   k++++++iD+ G  + r+k ++     +  ++l+++v  + +
  EFC38689.1 170 MGKNTEIEVIDVGGRRNERKKWIHC---FEDTHTLIYMVSLSEF 210
                 56999**************999988...4556788999875555 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0     3e-06    0.0053      22      54 ..      20      52 ..      16     105 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3e-06
      AAA_23 22 tlItGpNGaGKTTildAiklaLygetprlsrks 54
                +lI Gp  +GK+T++  +kl++ g+  + + ++
  EFC38689.1 20 VLILGPSDSGKSTLFHMLKLITSGHDVDAKFEN 52
                69********************99765555444 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0   0.00057         1       1      19 [.      19      37 ..      19      61 .. 0.85
   2 ?    5.4   0.0      0.01        19      33      87 ..     161     212 ..     141     244 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00057
                EEEEEESTTSSHHHHHHHH CS
    MMR_HSR1  1 evaivGrpNvGKStLinal 19
                +v+i+G + +GKStL+  l
  EFC38689.1 19 KVLILGPSDSGKSTLFHML 37
                689*************877 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.01
                 SSSE.EEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT...T CS
    MMR_HSR1  33 Trdi.negrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas...e 87 
                 T+ i  ++++  k++eie++D+ G         +++k++    e ++ ++++v++s   +
  EFC38689.1 161 TTGIlSYETMG-KNTEIEVIDVGG-RR------NERKKWIHCFEdTHTLIYMVSLSefnQ 212
                 44441444444.6689********.33......334444432222788999998774431 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.1   4.7e-06    0.0083       9      37 ..      15      43 ..       8     235 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 4.7e-06
                ETTSEEEEEESTTSSHHHHHHHHTTSS-- CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  9 kegekvaivGenGaGKStLlkllagllkp 37
                ++ ekv i+G++ +GKStL+ +l   ++ 
  EFC38689.1 15 RKREKVLILGPSDSGKSTLFHMLKLITSG 43
                6789****************999766654 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   2.1e-05     0.038      17     116 ..      14     148 ..       7     152 .. 0.78
   2 ?   -3.1   0.0       3.4   6.1e+03     140     161 ..     290     309 ..     272     332 .. 0.58
   3 ?   -2.7   0.0       2.4   4.3e+03      24      41 ..     324     341 ..     308     362 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.1e-05
    ATPase_2  17 repneiyfiYGpegsGKtaLlkeiienledkdkyviyyialreesiskldefie..eeeekkklekal............................... 82 
                 + ++e ++i Gp  sGK++L+  +    + +d +  + ++lr +s+  +++  e   e+e++ l++ +                               
  EFC38689.1  14 TRKREKVLILGPSDSGKSTLFHMLKLITSGHDVDAKFENNLRIVSSWVIERIWEamGEQERNHLKDLIpelrsvfentedanlatelqnrddcceilvt 112
                 55677889************988777778888999***************9999987888888888888877777777777777777777777777777 PP

    ATPase_2  83 ..giavpkaeleeilkeksklvfkaielllekikkk 116
                   +i++ +   e + ++    +f+++++l   i+ k
  EFC38689.1 113 lwKIPFFREFYESVWSRDGISMFENVKELVSRIEHK 148
                 777777777777777766666677777777777665 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.4
    ATPase_2 140 llvkeLlnliesltkekhlcvv 161
                 + + e+++ i++ t   +  ++
  EFC38689.1 290 SIITEFFKKIDRTT--IDSYHI 309
                 44445555444432..233344 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 2.4
    ATPase_2  24 fiYGpegsGKtaLlkeii 41 
                 +i+G ++  Kt+++   i
  EFC38689.1 324 MIFGERSAQKTTFISPCI 341
                 689999999999887766 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.0    0.0011         2       1      19 [.      19      37 ..      19      79 .. 0.84
   2 ?    1.4   0.0      0.19   3.5e+02      48      87 ..     166     206 ..     138     234 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0011
                EEEEESSTTSSHHHHHHCH CS
         Roc  1 KvvlvGdsgvGKtsllkrf 19
                Kv+++G s +GK++l++ +
  EFC38689.1 19 KVLILGPSDSGKSTLFHML 37
                99*************9866 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.19
                 TTBTTTTCEEEEEEEE-SGGCTTT.T-HHHHCTSCEEEEEE CS
         Roc  48 endkkvkkvklniWDtaGqerfrs.lhplylreaalailvy 87 
                 + ++  k+ ++++ D++G  + r+   +++   + l+ +v 
  EFC38689.1 166 SYETMGKNTEIEVIDVGGRRNERKkWIHCFEDTHTLIYMVS 206
                 34455678899999***987766525566655555544443 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.011        20       1      16 [.      19      34 ..      19      49 .. 0.88
   2 ?    2.2   0.0     0.053        94      48      81 ..     109     142 ..      87     162 .. 0.88
   3 ?    2.1   0.0     0.057     1e+02      44      87 ..     170     208 ..     154     239 .. 0.73
   4 ?   -2.9   0.0         2   3.5e+03      14      32 ..     320     338 ..     282     357 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.011
   Gtr1_RagA  1 kvLLmGksgsGKtsmr 16
                kvL++G+s sGK+++ 
  EFC38689.1 19 KVLILGPSDSGKSTLF 34
                8************975 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.053
   Gtr1_RagA  48 ltlnlwDcgGqeafveeylssqkeeifrnvgvli 81 
                 + + lw ++  ++f e+ +s++  ++f+nv+ l+
  EFC38689.1 109 ILVTLWKIPFFREFYESVWSRDGISMFENVKELV 142
                 67899*************************9987 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.057
   Gtr1_RagA  44 flgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDve 87 
                 + +n +++++D+gG+++  ++       + f++   liy++  +
  EFC38689.1 170 MGKNTEIEVIDVGGRRNERKKW-----IHCFEDTHTLIYMVSLS 208
                 45788999******99887775.....78899999999988777 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 2
   Gtr1_RagA  14 smrsiiFdnylardtlrlg 32 
                 s++++iF + +a+ t+++ 
  EFC38689.1 320 SVCEMIFGERSAQKTTFIS 338
                 4555555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       703  (0.0392102); expected 358.6 (0.02)
Passed bias filter:                      501  (0.0279436); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 2161.06
//
Query:       EFC38690.1  [L=255]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0048   16.6   0.3      0.017   14.9   0.3    1.9  1  LpxD          UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyl
  ------ inclusion threshold ------
      0.068   12.5  38.0      0.084   12.3  38.0    1.2  1  CDC27         DNA polymerase subunit Cdc27
       0.31    9.7  17.1       0.32    9.6  17.1    1.0  1  Hamartin      Hamartin protein
        7.1    6.2  33.0        9.7    5.7  33.0    1.2  1  DUF4045       Domain of unknown function (DUF4045)
        7.8    6.0  19.3         10    5.6  19.3    1.1  1  VIR_N         Virilizer, N-terminal


Domain annotation for each model (and alignments):
>> LpxD  UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.3   4.6e-06     0.017      28      61 ..      98     131 ..      94     132 .. 0.91

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 4.6e-06
                 GGCCC---SEEEEEHHHHCCHTTSCS.EESS-HH CS
        LpxD  28 kqlattkAgavivppdlaealpanaalivvenPy 61 
                 k+ ++tk +av+v ++ ++++++++ ++vve+P+
  EFC38690.1  98 KKKEETKSSAVVVEKSSKKQKKETKPAVVVEEPK 131
                 55689*******************999******7 PP

>> CDC27  DNA polymerase subunit Cdc27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3  38.0   2.3e-05     0.084     106     279 ..       4     167 ..       1     213 [. 0.41

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.3e-05
       CDC27 106 nkkndskdslirgaqagpivnkevkraeelgrpplaapaseakektangkkpkaakekaaketssakseskkksaekskdaskettkekaekaasskaa 204
                 nkkn++k s+i    ag  +++  k+ ++                             +a++++++  e  +++ ek+++++++ +k++++ka++ k+ 
  EFC38690.1   4 NKKNNKKTSAIASEVAGSSSKPSSKKTTT-----------------------------TAPPAAPVATEVVVEKVEKATPTTTTIEKKQTKKATTTKTT 73 
                 34444444444444444444444444443.............................33333333333333333333333333333333333333333 PP

       CDC27 205 slkkkasaksnimksffkakpaekkkkte..................akeqkveeeseeekekedkeleddsaaeeeeeeekstkkekr.rqkk 279
                 ++kk++  +++ + ++ +     +kkk+e                   k++ v ee +ee+e e +++++++++++++++e  t+ e + r+  
  EFC38690.1  74 QEKKNPDVAADKKRKLDQVVEEPAKKKEEtkssavvveksskkqkkeTKPAVVVEEPKEEEETEVVVEDEKEEKKKNKRKEAKTDIEVTlRKED 167
                 3333333333333333332222222222200000000000000000033334444444444444444444444444444444444433322222 PP

>> Hamartin  Hamartin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6  17.1   8.9e-05      0.32     333     512 ..      17     190 ..       1     242 [. 0.51

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 8.9e-05
    Hamartin 333 svcgmttppsspgivpttelelsssasllsskvsstpea......agkatpetTPakssrklppslsesavvvalpassrksspprkdeks.esskpdl 424
                  v+g + +pss++++                  + +p+a      ++++  ++TP +++ + ++++   ++  +++++ ++  + +k++k  + ++ + 
  EFC38690.1  17 EVAGSSSKPSSKKTTT-----------------TAPPAApvatevVVEKVEKATPTTTTIEKKQTKKA-TTTKTTQEKKNPDVAADKKRKLdQVVEEPA 97 
                 2344444444444443.................22222211111122222334444444332222222.222233333334445555555545566666 PP

    Hamartin 425 skqeevenekeleeslkskssvtlse...Lsdvikel...leaesedsvekeeeeaaisqelseiteekketlvsrggldspfsrtleslaksq 512
                 +k+ee++++  + e+ ++k+  +++    +++ ++e+   + +e e+ ++k++++++++ +  e+t +k++ ++s+ +++  f   ++   +s+
  EFC38690.1  98 KKKEETKSSAVVVEKSSKKQKKETKPavvVEEPKEEEeteVVVEDEKEEKKKNKRKEAKTD-IEVTLRKEDITMSEEEFKKCFHDAVKIYRGSK 190
                 6666666666666655544444433323222222222332222222333333333333333.57777887889999999998888777666665 PP

>> DUF4045  Domain of unknown function (DUF4045)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7  33.0    0.0027       9.7     211     368 ..      16     179 ..       1     183 [. 0.48

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0027
     DUF4045 211 seapgshskkssvsgas..............aeaskakeeaseeaekestekeespapasseeskesekeeekeseeekapskkaeaseekkeeeeese 295
                 se  gs sk+ss ++++              ++++ka++++++ ++k++++ + + +++++++++ + ++++k  +  ++p kk+e+  +k+ +   ++
  EFC38690.1  16 SEVAGSSSKPSSKKTTTtappaapvatevvvEKVEKATPTTTTIEKKQTKKATTTKTTQEKKNPDVAADKKRKLDQVVEEPAKKKEE--TKSSAVVVEK 112
                 222222222222222222234444443222222222333222222222222222222222333333335555555555666663333..3333333333 PP

     DUF4045 296 peeeeerkeapsllsptskaesdkplskserdsllkkpkpqspvkkDFRanLkkrevakekskkeepefknvF 368
                 ++++++++++p+++ +++k+e +  ++ ++ +++ kk k +++ + D   +L+k +++       e efk+ F
  EFC38690.1 113 SSKKQKKETKPAVVVEEPKEEEETEVVVEDEKEEKKKNKRKEAKT-DIEVTLRKEDITMS-----EEEFKKCF 179
                 444444579999999999999998877887777878888777777.*******9887664.....44566555 PP

>> VIR_N  Virilizer, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6  19.3    0.0028        10     121     241 ..      20     157 ..      11     177 .. 0.46

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0028
       VIR_N 121 GtvervlsedrvsipPppPapPvk..................elekedqynaspvrpeprePrtpelipaytgnvastpPpdddeeedaavpetveeek 201
                 G+  ++ s++++    +pPa+Pv                   e ++ ++     + +e+++P ++       ++v + p  +++ee++    + ++++k
  EFC38690.1  20 GSSSKPSSKKTT--TTAPPAAPVAtevvvekvekatpttttiEKKQTKKATTTKTTQEKKNPDVAADKKRKLDQVVEEPA-KKKEETKSSAVVVEKSSK 115
                 555555444444..456677776666677777777777664333333333344444555666666544555555554433.444444222222222233 PP

       VIR_N 202 eensekredyleeesP..eertslkaeekdseaereer.esse 241
                 ++++e++  ++ e +P  ee+t++++e+++ e+++++r e++ 
  EFC38690.1 116 KQKKETKPAVVVE-EPkeEEETEVVVEDEKEEKKKNKRkEAKT 157
                 3333333333322.23235666666666666655554422222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (255 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3762  (0.209828); expected 358.6 (0.02)
Passed bias filter:                      689  (0.0384294); expected 358.6 (0.02)
Passed Vit filter:                       165  (0.00920297); expected 17.9 (0.001)
Passed Fwd filter:                        51  (0.00284455); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.02u 0.41s 00:00:01.43 Elapsed: 00:00:00.57
# Mc/sec: 1341.32
//
Query:       EFC38691.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.2e-12   47.0   0.4    7.4e-12   46.2   0.4    1.4  1  Metallophos    Calcineurin-like phosphoesterase
    1.2e-08   35.3   0.1    8.9e-07   29.2   0.1    2.1  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d
  ------ inclusion threshold ------
       0.21   11.9   1.2       0.59   10.4   0.0    2.3  3  DUF3642        Bacterial lipoprotein


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.2   0.4   1.2e-15   7.4e-12       1     203 [.       1     248 [.       1     249 [. 0.59

  Alignments for each domain:
  == domain 1  score: 46.2 bits;  conditional E-value: 1.2e-15
                  EEEEEEESBTBTTCCTHHHHHHHHH.HHH......HHHTTESEEEEEST..SSSSSHHHHHHHHHHHHHHHHTSEEEEEC-TTSCHHH.HHHHHHHHH CS
  Metallophos   1 lrilvigDlHlalgggqlddllkll.ddl......lreekpdlvllaGD..lvdrgdlekellellaalvkypipvylllGNHegfee.ellnkygyl 88 
                  ++i +++DlH  +++ +l+++++++ +         +++++++++laGD  +v   +++++l++  +al++   +v+++ GNHe f+  e+++  +  
   EFC38691.1   1 MKIHLLSDLH-IEHFPDLAQFQDMYkE-RygnellENNNQANVLVLAGDigNVKKVGYQQFLVKA-SALYE---HVIIVGGNHE-FYGnEYFECMA-- 89 
                  7999******.5555556666666640.2444444555899********5555555999955555.99999...9*********.55444444433.. PP

                  HHHHHHHEHHHCEEETSEEEEEETTE......EEEEEEESE.....CEEE....THHHHHHHHHHHSCHHHHCC................HHHHHH.. CS
  Metallophos  89 gifsepwrsdaevfnnlplaslgsgs......lkvlllhGg.....spel....lvsldklgslnleleapepg................dewlkd.. 153
                      + ++ ++ev++n+   +  +         +v++  G       pe+     +s ++  +l +++e+  +                  e +k+  
   EFC38691.1  90 ----KMKEICKEVGENVHFLDKSKVEivdsetKEVYVFVGAilwsnIPEEsqlyVESAMNDYRLIKIKESGADSatllrtkhtvqmfkeeSEYIKQei 183
                  ....3344455555555555522222222233233333333445542222544423333333333333333333555555666334444444455599 PP

                  HHHHTTCSEEEEEESSESS.................CSSSCSCCHHHHHHHHHHTTESEEEEESSSS CS
  Metallophos 154 lekrekadwvivlgHsply.................rgsgylfgdealedllkkygvdlvisGHtHv 203
                   +++ + + viv++H  +                  r+  y f+ +       +  v ++++GHtH 
   EFC38691.1 184 EKAKINQQKVIVVSHNAPLnrgvsapqfetvdngstRSLNYAFATDLSS--IMDDHVIAWLFGHTHY 248
                  6666666677777776666699999999999988887788888887777..778889*********5 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.2   0.1   1.5e-10   8.9e-07       1     140 [.       1     259 [.       1     278 [. 0.79

  Alignments for each domain:
  == domain 1  score: 29.2 bits;  conditional E-value: 1.5e-10
  Metallophos_2   1 MklaiiSDlH.............snldaleavlealkevgvdaiihaGDl...eeeep....evleellela.pvlaVrGNnD............. 62 
                    Mk+ ++SDlH              + ++ +++le  +++  + +++aGD+   +        ++l ++ +l+  v++V GN++             
     EFC38691.1   1 MKIHLLSDLHiehfpdlaqfqdmYKERYGNELLENNNQA--NVLVLAGDIgnvK---KvgyqQFLVKASALYeHVIIVGGNHEfygneyfecmakm 91 
                    9*********97777777776665556666679998888..********95331...2233346777777778*********************** PP

  Metallophos_2  63 .........................................................................eevveedvlreaaelgtdlpeea 85 
                                                                                              ++ ++++ +e++ +++++ e+a
     EFC38691.1  92 keickevgenvhfldkskveivdsetkevyvfvgailwsnipeesqlyvesamndyrlikikesgadsatllrTKHTVQMFKEESEYIKQEI-EKA 186
                    ***************************************99999999999999988877777777765444422224444444444444444.444 PP

  Metallophos_2  86 elelagek.vlliHgdpl..................gvkdalaellkeaeegsd.vvvcGHtHvpevekeggvlv 140
                    +  ++++k + + H  pl                  ++++a+a +l++ ++++    ++GHtH  +++k ++++v
     EFC38691.1 187 K--INQQKvIVVSHNAPLnrgvsapqfetvdngstrSLNYAFATDLSSIMDDHViAWLFGHTHYSSLQKFNNTIV 259
                    4..444554888888877***************999999999999999888888899*******99999887766 PP

>> DUF3642  Bacterial lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.38   2.3e+03      49      62 ..      68      81 ..      33      87 .. 0.78
   2 ?   10.4   0.0   9.9e-05      0.59      15      57 ..     156     199 ..     139     216 .. 0.83
   3 ?   -3.6   0.1       2.3   1.4e+04      51      71 ..     257     280 ..     252     287 .. 0.60

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.38
     DUF3642 49 nklilvGddvktyk 62
                +++i+vG + + y 
  EFC38691.1 68 EHVIIVGGNHEFYG 81
                68899999987774 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 9.9e-05
     DUF3642  15 n.dqlTlkkegetglieleesdg.dkpidpvtldadnklilvGdd 57 
                 + d+ Tl  +++t ++ +ees++ +++i++++++ ++k+i+v  +
  EFC38691.1 156 GaDSATLLRTKHTVQMFKEESEYiKQEIEKAKIN-QQKVIVVSHN 199
                 2599***99999999999999975789*******.9999999766 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 2.3
     DUF3642  51 lilvGdd...vktyklvgnqltvd 71 
                 +i+  +    ++ + +++n  +vd
  EFC38691.1 257 TIVASNQlgyLRGFSKEENSYKVD 280
                 444444455566677777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1399  (0.07803); expected 358.6 (0.02)
Passed bias filter:                      660  (0.0368119); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 1898.46
//
Query:       EFC38692.1  [L=514]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1812  (0.101065); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.53
# Mc/sec: 2927.66
//
Query:       EFC38693.1  [L=559]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-39  132.1  49.8    1.3e-07   31.2   0.4   11.0 11  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2   0.4   7.5e-12   1.3e-07       6      42 ..      81     117 ..      79     128 .. 0.92
   2 !   13.5   0.0   2.5e-06     0.045      25      48 ..     168     191 ..     153     192 .. 0.81
   3 !   22.4   0.2   4.1e-09   7.3e-05       1      45 [.     169     213 ..     169     218 .. 0.94
   4 !    8.2   0.1   0.00011       2.1       1      35 [.     194     228 ..     194     237 .. 0.82
   5 !    9.6   0.6   4.2e-05      0.75       1      41 [.     252     292 ..     252     298 .. 0.89
   6 !   20.1   0.5   2.2e-08   0.00039       2      47 ..     306     352 ..     306     366 .. 0.82
   7 !    9.4   0.1   4.6e-05      0.83      13      32 ..     369     388 ..     366     391 .. 0.90
   8 !   28.2   0.2   6.5e-11   1.2e-06      10      49 .]     397     437 ..     393     437 .. 0.83
   9 !   19.0   0.9   4.7e-08   0.00084       1      38 [.     439     474 ..     439     489 .. 0.87
  10 !    3.6   0.1    0.0031        56      20      45 ..     485     510 ..     479     515 .. 0.66
  11 !   16.0   2.9   4.2e-07    0.0076       3      41 ..     519     557 ..     518     559 .] 0.91

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 7.5e-12
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 l++++++ +a+k+++ +LknD+++vlk+++ ng  ++
  EFC38693.1  81 LNILETFKEAFKFVPQSLKNDRNFVLKCLEVNGELFK 117
                 7899*****************************9876 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 2.5e-06
     DUF4116  25 nDkeivlkAvkqngtalsyaseeL 48 
                 +++e+ +kAv +n+t++s a+  L
  EFC38693.1 168 SNREFFMKAVSINPTIFSCACRTL 191
                 5****************9988666 PP

  == domain 3  score: 22.4 bits;  conditional E-value: 4.1e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 +rE+ ++av++n+ ++  +   Lk D e++ +Avk n   l++as
  EFC38693.1 169 NREFFMKAVSINPTIFSCACRTLKADDELLFEAVKYNRQHLKFAS 213
                 8******************************************99 PP

  == domain 4  score: 8.2 bits;  conditional E-value: 0.00011
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 D E+  eavk n  +lk++s +   +++++ +A++
  EFC38693.1 194 DDELLFEAVKYNRQHLKFASLKQLENRNLIFRACE 228
                 55888999999999999999766669999999887 PP

  == domain 5  score: 9.6 bits;  conditional E-value: 4.2e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 + E++le+v+k+ ++   + + +kn+  i++k +++ ++ +
  EFC38693.1 252 NPELALEIVEKDHESVACAIKHFKNHEKIIMKVIEIAPYLI 292
                 68**********9999999999************9988754 PP

  == domain 6  score: 20.1 bits;  conditional E-value: 2.2e-08
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkA..vkqngtalsyasee 47 
                 +Ei+l a+kk+++++kyl  +++ D++i + A  +   ++++ y+s+e
  EFC38693.1 306 KEICLLALKKDPLIYKYLG-RFRYDRDIFKFAsdCGHISISYLYLSPE 352
                 7******************.********87764444444456666655 PP

  == domain 7  score: 9.4 bits;  conditional E-value: 4.6e-05
     DUF4116  13 gsalkylseeLknDkeivlk 32 
                 +++++ l+e+Lk+D++++l+
  EFC38693.1 369 PLYFERLDENLKRDRDVILA 388
                 789999************97 PP

  == domain 8  score: 28.2 bits;  conditional E-value: 6.5e-11
     DUF4116  10 kkngsalkylseeLknDkeivlkAvk..qng.talsyaseeLr 49 
                 ++  +  kyl+ +L nDke++l+Av+  +ng ++ls+as+eL+
  EFC38693.1 397 QQ-EFKEKYLP-NLENDKEFLLEAVRrkRNGfSILSFASDELK 437
                 44.677899**.**************65577779*******97 PP

  == domain 9  score: 19.0 bits;  conditional E-value: 4.7e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 DrE++l  ++k+ ++l+ ++  L++D+eiv   +k n 
  EFC38693.1 439 DRELILSDIRKC-NNLNLVPIHLRSDREIVETFIK-NV 474
                 9**********7.66*****************999.44 PP

  == domain 10  score: 3.6 bits;  conditional E-value: 0.0031
     DUF4116  20 seeLknDkeivlkAvkqngtalsyas 45 
                 +++L  D e+v + +   ++ ++ ++
  EFC38693.1 485 PDSLLEDSEFVWRMIDLRPNLIKKFP 510
                 67777777777666666666555555 PP

  == domain 11  score: 16.0 bits;  conditional E-value: 4.2e-07
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                  i+l+ ++kn ++ + +s+eL+ D++i l+ +k+  +++
  EFC38693.1 519 KIILKMISKNILCNEIISNELREDRDIKLALIKIGNYPF 557
                 69*******************************987776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (559 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       559  (0.0311785); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.26s 00:00:00.92 Elapsed: 00:00:00.48
# Mc/sec: 3512.69
//
Query:       EFC38694.1  [L=499]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (499 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1087  (0.060628); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 2840.01
//
Query:       EFC38695.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.2e-31  107.3  21.4    6.2e-31  107.3  21.4    2.0  2  Snf7            Snf7
     0.0015   18.8   7.2     0.0015   18.8   7.2    2.3  3  DUF5082         Domain of unknown function (DUF5082)
     0.0086   15.7  18.3      0.019   14.5  16.9    2.0  1  PspA_IM30       PspA/IM30 family
  ------ inclusion threshold ------
      0.014   15.7   0.2      0.092   13.1   0.2    2.4  1  DUF3243         Protein of unknown function (DUF3243)
      0.032   14.5   4.0        2.8    8.3   0.8    2.8  2  WXG100          Proteins of 100 residues with WXG
      0.052   12.4   3.3      0.068   12.0   3.3    1.1  1  DUF3573         Protein of unknown function (DUF3573)
      0.067   11.8   1.7       0.09   11.4   1.7    1.1  1  DUF3138         Protein of unknown function (DUF3138)
      0.082   13.0   0.8       0.22   11.6   0.1    2.0  2  DUF3791         Protein of unknown function (DUF3791)
       0.25   11.2   0.1       0.25   11.2   0.1    2.7  2  Synaptobrevin   Synaptobrevin
        5.5    6.3   8.0        8.3    5.7   8.0    1.2  1  RNA_pol_Rpb1_5  RNA polymerase Rpb1, domain 5
        9.6    6.5   9.1    2.8e+02    1.9   9.0    2.8  1  DUF948          Bacterial protein of unknown function (DUF948


Domain annotation for each model (and alignments):
>> Snf7  Snf7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.3  21.4   3.8e-34   6.2e-31       2     160 ..      30     197 ..      29     210 .. 0.93
   2 ?    0.9   1.6      0.19   3.1e+02     137     150 ..     212     225 ..     198     226 .] 0.84

  Alignments for each domain:
  == domain 1  score: 107.3 bits;  conditional E-value: 3.8e-34
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTT-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
        Snf7   2 airsLrkaerkldkkqeslekkikkleaelkklakkgnkdralllLKqkkryekqldqldnqlanleqvslaienlksnkevlnamkqgakamkamnkk 100
                 +i ++ +++  l+k++  l kk +++ea+++k+ +++n+ +a ++ K+kk+y  q+++l++q++nle+ +l++e   +n e+l+a kq+  a+k++++ 
  EFC38695.1  30 SINNIHETIGTLEKREMALLKKSEEEEAKARKFLQENNRTAAANCIKKKKQYQTQIQRLQGQKQNLETTLLTLEDSVTNVETLKAQKQASDAIKKVYNG 128
                 688999********************************************************************************************* PP

                 TCCHHHHHHHHHHHHHHHHHTCHHHHHHHHHTT-GGTTHHHHHHHHHHHHHHHHHCSH............H CS
        Snf7 101 vdidkidklmdeiedqmekaeeisEalsrslddadeedEeeleaeLdaLeqelgdeell...........d 160
                 ++ ++i+++md+i+d m+  ++i +al++++  ++ +dE el +eL++Le++  +ee++           d
  EFC38695.1 129 MKTEDIEDIMDDIRDTMDDVNQIGDALAQNV--GPVFDEGELLDELEQLESDAHEEEMAkiklpkekvtkD 197
                 *******************************..58*****************9999986666555444444 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.19
                 TTHHHHHHHHHHHH CS
        Snf7 137 edEeeleaeLdaLe 150
                  +E+ele+eL+aL 
  EFC38695.1 212 PEEAELEKELEALM 225
                 579********995 PP

>> DUF5082  Domain of unknown function (DUF5082)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.93   1.5e+03      74      90 ..      26      42 ..      11      63 .. 0.55
   2 !   18.8   7.2     9e-07    0.0015       6      93 ..      65     155 ..      61     161 .. 0.76
   3 ?   -3.1   0.1       5.6   9.1e+03      96     107 ..     171     182 ..     164     196 .. 0.60

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.93
     DUF5082 74 nlessyqtyvdkldeli 90
                +  +s++++++ + +l+
  EFC38695.1 26 EHNKSINNIHETIGTLE 42
                44444444444443333 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 9e-07
     DUF5082   6 sklqaqiaelrseiaaleekIerLkeaktklsdekeslkqkkkklekplnsse.......sWkGkeennydgirsnlessyqtyvdkldelidai 93 
                 ++++ ++a + ++ ++++ +I+rL+  k+ l+++  +l+++ +++e+  ++++        ++G ++++ ++i  ++ + ++    ++ ++ da+
  EFC38695.1  65 ENNRTAAANCIKKKKQYQTQIQRLQGQKQNLETTLLTLEDSVTNVETLKAQKQasdaikkVYNGMKTEDIEDIMDDIRDTMD----DVNQIGDAL 155
                 6889999****************************************99998766555555555555555555555544444....444444444 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 5.6
     DUF5082  96 EIerLenqisea 107
                 E e+Le++  e 
  EFC38695.1 171 ELEQLESDAHEE 182
                 445555444433 PP

>> PspA_IM30  PspA/IM30 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5  16.9   1.2e-05     0.019      57     207 ..      28     181 ..      15     197 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.2e-05
   PspA_IM30  57 erkleeqkeqakklekkAkaALtkg..eeeLArealaeikslekqaealetqlaqqrsaveqlrkqlealetkieelkakkellkarekaakaqeavqk 153
                  + +++  e +  lek+  a+L+k   ee+ Ar++l+e  +    a++  ++ +q +++++ l++q ++let +  l++ ++ +   +++ +a  a++k
  EFC38695.1  28 NKSINNIHETIGTLEKREMALLKKSeeEEAKARKFLQENNR--TAAANCIKKKKQYQTQIQRLQGQKQNLETTLLTLEDSVTNVETLKAQKQASDAIKK 124
                 55677777888888888777777775555567777776554..45666666677777778888888888888888888888888888888888889999 PP

   PspA_IM30 154 slgklstesatdslerieeKieerearadaaaelae...saqdldakleaagiqkev 207
                  + +++te+  d ++ i++  ++  +  da a+  +   ++  l  +le+++ ++  
  EFC38695.1 125 VYNGMKTEDIEDIMDDIRDTMDDVNQIGDALAQNVGpvfDEGELLDELEQLESDAHE 181
                 999999999999999999999999988888888888664333466666666655544 PP

>> DUF3243  Protein of unknown function (DUF3243)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.2   5.6e-05     0.092      34      72 ..     148     186 ..     113     189 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 5.6e-05
                 HHHHHHHHHT-----SHHHHHHHHHHHC--HHHHHHHHH CS
     DUF3243  34 AyevGdyLaekvdpknkeerlLkeLWkvadeeerkalAs 72 
                   ++Gd La++v p  +e +lL eL +  ++   + +A+
  EFC38695.1 148 VNQIGDALAQNVGPVFDEGELLDELEQLESDAHEEEMAK 186
                 479**********************98877777777775 PP

>> WXG100  Proteins of 100 residues with WXG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.8    0.0017       2.8      10      39 ..      68      97 ..      65     101 .. 0.91
   2 ?    5.6   0.1     0.011        18      30      73 ..     115     158 ..     103     162 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0017
                HHHHHHHHHHHHHHHHHHHHHHHHHHHCGC CS
      WXG100 10 rqaaarfqkqaeeledelqrlkaevdalqs 39
                r+aaa+  k++++ ++++qrl+++ ++l+ 
  EFC38695.1 68 RTAAANCIKKKKQYQTQIQRLQGQKQNLET 97
                789***********************9965 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.011
                 HHHHHHHCGCGCTHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      WXG100  30 lkaevdalqsgWsGaaadafqaefeewkqaaqklvdaLeeisea 73 
                  k+  da++  ++G   +  ++ ++ ++ +++++++  + ++++
  EFC38695.1 115 QKQASDAIKKVYNGMKTEDIEDIMDDIRDTMDDVNQIGDALAQN 158
                 45555666667777777777777777777777777777666665 PP

>> DUF3573  Protein of unknown function (DUF3573)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   3.3   4.2e-05     0.068      27     133 ..      62     165 ..      37     171 .. 0.53

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.2e-05
     DUF3573  27 yaesneqtsksnlidkelilklqkqikelqaeinhlketknsnesaqfttysskvedsklprslldn.keskdlsqv......qktsvdiltnidaess 118
                 + + n++t+ +n i k+   + q qi++lq++ ++l+ t  +            v + +  +++++  +  k++++       ++   di + +d  + 
  EFC38695.1  62 FLQENNRTAAANCIKKKK--QYQTQIQRLQGQKQNLETTLLT--------LEDSVTNVETLKAQKQAsDAIKKVYNGmktediEDIMDDIRDTMDDVNQ 150
                 444455555555555543..5566666666666666655554........4444444333333222202233333332211113333444444455677 PP

     DUF3573 119 iinlaskplGgifnq 133
                 i +   +++G +f++
  EFC38695.1 151 IGDALAQNVGPVFDE 165
                 888888899999986 PP

>> DUF3138  Protein of unknown function (DUF3138)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   1.7   5.5e-05      0.09      19     108 ..      70     161 ..      61     164 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 5.5e-05
     DUF3138  19 aaaatadrikalkaqltalqrqvkelraalaaakaaaGgkissqkaaaaaaaa.aeaaaalteddvaqlkeqianaelkvdalqea..attGp 108
                 aaa+  ++ k+ ++q+++lq q ++l+++l++ + +    + + ka   a++a  +  + +  +d++++ + i ++   v+++ +a   + Gp
  EFC38695.1  70 AAANCIKKKKQYQTQIQRLQGQKQNLETTLLTLEDSVTN-VETLKAQKQASDAiKKVYNGMKTEDIEDIMDDIRDTMDDVNQIGDAlaQNVGP 161
                 455667788999********************9999877.88888888777773456678888999999999998888888887762145566 PP

>> DUF3791  Protein of unknown function (DUF3791)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.6   2.5e+03      36      53 ..      21      38 ..      20      43 .. 0.83
   2 ?   11.6   0.1   0.00013      0.22      28      57 ..     116     145 ..     109     147 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.6
     DUF3791 36 dcYevlHtqSkeyivedi 53
                d +e +H  S+++i e i
  EFC38695.1 21 DTHEPEHNKSINNIHETI 38
                568999999999999988 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00013
     DUF3791  28 sgvldylidcYevlHtqSkeyivedideyl 57 
                  ++ d +++ Y+++ t+++e+i++di + +
  EFC38695.1 116 KQASDAIKKVYNGMKTEDIEDIMDDIRDTM 145
                 556688999*****************9877 PP

>> Synaptobrevin  Synaptobrevin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   2.3       0.2   3.2e+02      22      69 ..      33      81 ..      27      98 .. 0.80
   2 ?   11.2   0.1   0.00015      0.25       3      38 ..     139     174 ..     137     183 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.2
                   HHHHCHCCCCCHHH.HCCCCHHHHHHHHHHHHHHHHHHHHHHHHTXXXX CS
  Synaptobrevin 22 Nidkvlergeklde.LvdktenLqssaqqFkkqarklkrkmwwknmkli 69
                   Ni++ +   ek ++ L +k+e+ +++a++F ++ ++ + + ++k+ k +
     EFC38695.1 33 NIHETIGTLEKREMaLLKKSEEEEAKARKFLQENNRTAAANCIKKKKQY 81
                   5555555555555338899*************99999999999998866 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00015
                    XHHHHHHHHHHCCCCHHCCHHHHCHCCCCCHHHHCC CS
  Synaptobrevin   3 dklakikaevdevkdimkeNidkvlergekldeLvd 38 
                    d ++ + ++v+++ d + +N+  v + ge ldeL++
     EFC38695.1 139 DDIRDTMDDVNQIGDALAQNVGPVFDEGELLDELEQ 174
                    679999****************************87 PP

>> RNA_pol_Rpb1_5  RNA polymerase Rpb1, domain 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   8.0    0.0051       8.3     121     226 ..      41     145 ..      13     151 .. 0.63

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0051
                     -SS-EEEEEB-SSSSSCHHHCHHHHHHHSECBTTEEEEEEEEEEEEEEET....EEEEEEECS--HHHHTTSTTTBETTTEEESSHHHHHHHHCH CS
                     xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  RNA_pol_Rpb1_5 121 iksksltvllvdeeakelekakkvkkaiekgikkikrilvkeaekgkeee....kelvletegvnlsevlkveevvdageilsndiaeileilgi 211
                     ++++  ++ l+++ ++e +ka+k+ +++++      +++ k+++++++ +    ++  let  + l++ +++ e+++a+++ s+ i+++++ +  
      EFC38695.1  41 LEKR--EMALLKKSEEEEAKARKFLQENNR--TAAANCIKKKKQYQTQIQrlqgQKQNLETTLLTLEDSVTNVETLKAQKQASDAIKKVYNGMKT 131
                     2333..333444443344444444333333..3344444444444444445555566799999****99999999***************99999 PP

                     HHHHHHHHHHHHHHH CS
                     xxxxxxxxxxxxxxx RF
  RNA_pol_Rpb1_5 212 eaarkallkeiqevy 226
                     e  +  ++++i++++
      EFC38695.1 132 EDIED-IMDDIRDTM 145
                     98765.667777776 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   9.0      0.17   2.8e+02      25      83 ..     116     154 ..      22     182 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.17
      DUF948  25 kktldeaaatieele.kqvdpilkevedllakvnelledvneklekvdplteavadlges 83 
                 k+  d++++  ++++ ++++ i+++++d+++ vn+                     +g++
  EFC38695.1 116 KQASDAIKKVYNGMKtEDIEDIMDDIRDTMDDVNQ---------------------IGDA 154
                 22222222222222223333333333333333333.....................3333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2858  (0.159407); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 1345.99
//
Query:       EFC38696.1  [L=1494]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-38  129.3  11.9    0.00027   20.8   0.0   14.5 14  NHL           NHL repeat
    1.2e-16   60.7  54.8    0.00018   21.8   6.5    4.8  4  EGF_2         EGF-like domain
    9.9e-10   38.4  10.8     0.0033   17.0   0.2    6.5  6  SGL           SMP-30/Gluconolactonase/LRE-like region
    5.8e-05   23.5   0.0    5.8e-05   23.5   0.0    2.5  1  GPS           GPCR proteolysis site, GPS, motif
     0.0035   17.3   0.4          9    6.1   0.0    4.6  3  Phytase-like  Esterase-like activity of phytase
     0.0075   15.7   4.1      0.017   14.5   4.1    1.6  1  DAG1          Dystroglycan (Dystrophin-associated glycoprotei
  ------ inclusion threshold ------
      0.024   14.0   0.0      0.068   12.5   0.0    1.9  1  GSDH          Glucose / Sorbosone dehydrogenase
        0.1   12.8   6.8        5.9    7.2   0.1    5.5  5  Arylesterase  Arylesterase
        0.1   12.9  44.5      0.052   13.9   2.0    5.3  4  EGF           EGF-like domain
       0.21   11.4   6.1       0.36   10.7   6.1    1.4  1  RIFIN         Rifin
       0.38   10.7   3.0        1.3    9.0   3.0    2.0  1  Syndecan      Syndecan domain


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1      0.45   7.3e+02       6      25 ..      60      80 ..      59      83 .. 0.74
   2 !    9.5   0.0   0.00062         1       3      27 ..     116     140 ..     114     141 .. 0.89
   3 !   14.0   0.0   2.3e-05     0.038       2      20 ..     174     192 ..     173     199 .. 0.84
   4 ?   -0.1   0.0      0.71   1.2e+03       3      17 ..     270     284 ..     269     285 .. 0.88
   5 !    7.4   0.0    0.0031         5       2      27 ..     325     349 ..     324     350 .. 0.86
   6 !   19.9   0.1   3.2e-07   0.00053       1      22 [.     496     517 ..     496     518 .. 0.94
   7 !   20.8   0.0   1.7e-07   0.00027       1      28 []     549     576 ..     549     576 .. 0.95
   8 !    8.5   0.0    0.0013       2.1       2      27 ..     607     633 ..     607     634 .. 0.87
   9 ?    1.8   0.0      0.18     3e+02       9      19 ..     724     734 ..     722     738 .. 0.82
  10 !    5.8   0.0    0.0096        16       1      16 [.     772     787 ..     772     787 .. 0.90
  11 ?    3.3   0.0     0.061        99      11      27 ..     835     851 ..     830     852 .. 0.82
  12 ?    2.5   0.1      0.11   1.8e+02       5      26 ..     885     905 ..     882     906 .. 0.87
  13 !   11.7   0.0   0.00013       0.2       1      23 [.     939     961 ..     939     965 .. 0.91
  14 !   12.1   0.0   9.8e-05      0.16       1      26 [.     996    1021 ..     996    1021 .. 0.95

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.45
                EEEEE.TTTEEEEEECCCTEE CS
         NHL  6 Gvavd.snGdiyVaDsenhrv 25
                G+++d  nG+iy aD  n++v
  EFC38696.1 60 GLVADnRNGNIYYADGLNSQV 80
                788888888888888777776 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00062
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                  P G a++s Gd+++ Ds  +rv++
  EFC38696.1 116 LPYGAALNSKGDVFIVDSSQNRVKK 140
                 57799*****************986 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 2.3e-05
                 SSEEEEEEETTTEEEEEEC CS
         NHL   2 nyPhGvavdsnGdiyVaDs 20 
                   P+++av++++++yV+D 
  EFC38696.1 174 TAPRCIAVSPDDEVYVCDA 192
                 56****************4 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.71
                 SEEEEEEETTTEEEE CS
         NHL   3 yPhGvavdsnGdiyV 17 
                 +P+ ++ +snGd yV
  EFC38696.1 270 SPRTIVFNSNGDMYV 284
                 6999********998 PP

  == domain 5  score: 7.4 bits;  conditional E-value: 0.0031
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 ++P G+a+  n+ +y++Ds n r+++
  EFC38696.1 325 SFPFGLAI-YNNSLYISDSSNYRIRK 349
                 67778999.5**************87 PP

  == domain 6  score: 19.9 bits;  conditional E-value: 3.2e-07
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 +n P+Gva+++nG++y++Ds n
  EFC38696.1 496 LNGPTGVAISPNGEVYISDSSN 517
                 799****************887 PP

  == domain 7  score: 20.8 bits;  conditional E-value: 1.7e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 +++P G+a ++nGd++++D +n+r+++F
  EFC38696.1 549 LANPMGIAFLPNGDLIISDAKNNRIRKF 576
                 57899*********************99 PP

  == domain 8  score: 8.5 bits;  conditional E-value: 0.0013
                 SSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvqv 27 
                 nyP+G++v+ sn +i+ aD+ n r+++
  EFC38696.1 607 NYPTGICVNsSNSEIFFADTFNYRIRK 633
                 79*******999999999988888875 PP

  == domain 9  score: 1.8 bits;  conditional E-value: 0.18
                 EETTTEEEEEE CS
         NHL   9 vdsnGdiyVaD 19 
                  ++nGdiyV++
  EFC38696.1 724 FSPNGDIYVSC 734
                 569******86 PP

  == domain 10  score: 5.8 bits;  conditional E-value: 0.0096
                 BSSEEEEEEETTTEEE CS
         NHL   1 fnyPhGvavdsnGdiy 16 
                 +++P G+av++nG+++
  EFC38696.1 772 LSNPGGLAVNTNGELI 787
                 689**********986 PP

  == domain 11  score: 3.3 bits;  conditional E-value: 0.061
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                 ++ diy +D +n+r+++
  EFC38696.1 835 TDTDIYLSDQGNNRIRK 851
                 5669***********87 PP

  == domain 12  score: 2.5 bits;  conditional E-value: 0.11
                 EEEEEETTTEEEEEECCCTEEE CS
         NHL   5 hGvavdsnGdiyVaDsenhrvq 26 
                 ++v++ s+G+i+ +Ds+++ ++
  EFC38696.1 885 NDVRI-STGEIVFTDSGHNKIR 905
                 57888.8************997 PP

  == domain 13  score: 11.7 bits;  conditional E-value: 0.00013
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +n+P ++ ++s+G+++++D++n+
  EFC38696.1 939 LNNPGSIGYLSTGELIITDTGNN 961
                 799*******************8 PP

  == domain 14  score: 12.1 bits;  conditional E-value: 9.8e-05
                  BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenhrvq 26  
                  +++P G++++++G+i+  Ds+n+rv+
  EFC38696.1  996 LSNPKGLSILNDGRIVFVDSGNFRVR 1021
                  689*********************96 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   8.3   6.8e-06     0.011       5      32 .]    1055    1081 ..    1051    1081 .. 0.89
   2 !   19.9   6.7   4.5e-07   0.00073       7      32 .]    1096    1120 ..    1090    1120 .. 0.91
   3 !   20.8   9.4   2.2e-07   0.00036       4      32 .]    1141    1168 ..    1139    1168 .. 0.91
   4 !   21.8   6.5   1.1e-07   0.00018       5      32 .]    1196    1222 ..    1192    1222 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 6.8e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+g+G+C ++   C C++gy+G +C
  EFC38696.1 1055 SKVCSGNGVCQSLD-SCLCSNGYSGVNC 1081
                  778********999.7**********99 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 4.5e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G+C +++ +C+C+ gy+G +C
  EFC38696.1 1096 VCSGRGVCQSLN-NCSCSMGYYGVNC 1120
                  6********899.8**********99 PP

  == domain 3  score: 20.8 bits;  conditional E-value: 2.2e-07
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C+g+G+C +++ +C+C++gy+G +C
  EFC38696.1 1141 NSNVCSGRGICQSLN-NCSCFTGYSGLNC 1168
                  4789********899.8*********999 PP

  == domain 4  score: 21.8 bits;  conditional E-value: 1.1e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C  + ++C+C+sgy+G +C
  EFC38696.1 1196 STVCSGRGICQLL-NNCSCFSGYSGLNC 1222
                  578*******945.59*********999 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.17   2.7e+02     188     214 ..      60      87 ..      38      91 .. 0.81
   2 ?   -1.3   0.0      0.82   1.3e+03     130     166 ..     111     146 ..      97     202 .. 0.67
   3 ?    3.3   0.0     0.032        52       5      78 ..     234     306 ..     230     317 .. 0.87
   4 !   17.0   0.2     2e-06    0.0033      11     216 ..     334     583 ..     329     590 .. 0.75
   5 !   12.3   0.1   5.6e-05     0.092      95     169 ..     559     642 ..     555     714 .. 0.63
   6 !    5.7   0.4    0.0059       9.7      39     169 ..     772     915 ..     759     970 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.17
         SGL 188 GlavDa.eGnvwvAvwgggkvvrfdpdG 214
                 Gl+ D+ +Gn++ A   +++v+ fd++G
  EFC38696.1  60 GLVADNrNGNIYYADGLNSQVRYFDTNG 87 
                 5788988999999999999999999988 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.82
         SGL 130 lddltipNGlawspdgktlYlaDsltrkiwaydvdae 166
                  d+l+ p G a+++ g+ ++ +Ds ++++ ++ ++++
  EFC38696.1 111 NDSLSLPYGAALNSKGDVFI-VDSSQNRVKKVFYNST 146
                 56777888888888888777.7888888888777544 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.032
         SGL   5 pvwdeeegaLlwvDilgqrihrldpatgketvldtpesvGaiaprkdgrlvvasksglalldlasgeletlade 78 
                 +  ++ +++L+++D l++ i  +  ++  +t++++ ++ +++++  +g ++v  ++   ++++ +g  +++a +
  EFC38696.1 234 IAFHPITKELFYSDLLANVIRYIARNGSVYTYASITSPRTIVFN-SNGDMYVSISTANQIIKVVNGIATVIANS 306
                 56778899**********99999999999999************.99*****9999999998888888888876 PP

  == domain 4  score: 17.0 bits;  conditional E-value: 2e-06
         SGL  11 egaLlwvDilgqrihrldpatgketv...................ldtpesvGaiaprkdgrlvvasksglall....dlasgeletlade....ee.. 80 
                 +++L+ +D  + ri ++d+ ++  ++                   +++ ++++ +++ + ++l++  ++++++l    +++++ +e +a +    ++  
  EFC38696.1 334 NNSLYISDSSNYRIRKIDLTSNIISTvagdgskqysarypgyildVPLASPLSTFYNSQTDELLMVDNNRVLRLnsltNYKNSLIESIAGNgvlaVDvd 432
                 678999999999999999999998888999999999777777755555559999999777999999999999995443344444444444443331144 PP

         SGL  81 .dekpllrfNDg....vvdpdGrlwfGtmgdeeakgeev.......galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdae. 166
                  +   ++++N +    + ++ G +++Gt g   + ++++       g++ ++++d   + ++ +l+ p G+a+sp g+ +Y+ Ds ++ i ++d +   
  EFC38696.1 433 gKLGNQTSLNSAcsvfQSEATGDIYIGTVGSVLKLSKSNqlvstiaGTISKYTGD-GSSAIQAQLNGPTGVAISPNGE-VYISDSSNDVIRKIDTNGAi 529
                 43346677777522124578899*******9999888888899999999999999.67788999***********885.899***********998651 PP

         SGL 167 ggklsnrrvfadlkkge...gepDGlavDaeGnvwvAvwgggkvvrfdpd.Gkl 216
                 ++ +++   f+d +       +p G+a   +G +++   +++++++f+   G++
  EFC38696.1 530 STVVGSSSGFLDASARRaqlANPMGIAFLPNGDLIISDAKNNRIRKFSISsGNV 583
                 344666777788777776676699999999999999999999999988776665 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 5.6e-05
         SGL  95 pdGrlwfGtmgdeeakgeev..........galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggk 169
                 p+G l++ + ++++ ++ +           ++l  ++++  l+ v+++++ p G+++++ ++ +++aD+ + +i ++d   +  +
  EFC38696.1 559 PNGDLIISDAKNNRIRKFSIssgnvttiagTGLTTYNGE-GLVGVATNINYPTGICVNSSNSEIFFADTFNYRIRKIDSTGTIRT 642
                 566666666666666655556633333333344444444.59999*******************************998655444 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.0059
         SGL  39 tpesvGaiaprkdgrlvvasksglall....dlasgeletladeeedekpllrfNDgvvdp....dGrlwfGtmgdeeakgeev.........galyrl 120
                 ++++ G++++ ++g+l++a++sgl  +    +l+ g + t+a    d    +r N g+v++    d  ++  + g+++ ++ +          ga y  
  EFC38696.1 772 LSNPGGLAVN-TNGELIFAASSGLSNYdgikKLSGGMVATIAGGIGDGGLAIRANIGKVSAisvtDTDIYLSDQGNNRIRKISLstgiissvvGAFYST 869
                 5567788888.9999999999999888444447778888888887777788888888887533336667777777777777665888888888888888 PP

         SGL 121 dpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggk 169
                 d +  l   +++++  N + +s     + ++Ds ++ki + d++  g+ 
  EFC38696.1 870 DNGDNLAN-QTNINLVNDVRISTG--EIVFTDSGHNKIRKTDLSGRGKV 915
                 88855544.456777787777764..46678888888888888877664 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   3.5e-08   5.8e-05       2      45 .]    1371    1423 ..    1370    1423 .. 0.87

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 3.5e-08
         GPS    2 sCvfWdeeneetgsWsteGCel............tesdnknetvCsCnHLtsFAvL 45  
                  sCv++   +e+ ++W ++G e+             + + + ++ C  nHLtsF+v+
  EFC38696.1 1371 SCVYY---EENSKEWKSDGMETeiknleihnladGNITLTLSILCNTNHLTSFSVI 1423
                  8****...55689*******99999*******994444678899**********96 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.0    0.0055         9      72     117 ..     501     546 ..     464     554 .. 0.83
   2 ?    3.1   0.0     0.046        75      72     100 ..     554     583 ..     547     589 .. 0.90
   3 ?    0.5   0.1      0.28   4.6e+02      78     104 ..     836     862 ..     825     976 .. 0.54

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0055
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkllrelplpaellpaaspd 117
                   g+a++p+g++++s+  +  i+++d +G + + +    ++l a++++
    EFC38696.1 501 GVAISPNGEVYISDSSNDVIRKIDTNGAISTVVGSSSGFLDASARR 546
                   8999*************************99998888887666544 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.046
  Phytase-like  72 giavapdgtfwvssEggpfilefdad.Gkl 100
                   gia+ p+g++++s+  +++i++f+ + G++
    EFC38696.1 554 GIAFLPNGDLIISDAKNNRIRKFSISsGNV 583
                   89**********************887887 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.28
  Phytase-like  78 dgtfwvssEggpfilefdad.Gkllrel 104
                   d ++++s+ g+++i++++++ G +++++
    EFC38696.1 836 DTDIYLSDQGNNRIRKISLStG-IISSV 862
                   4445555555555555554422.22222 PP

>> DAG1  Dystroglycan (Dystrophin-associated glycoprotein 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   4.1   1.1e-05     0.017      36     175 ..    1338    1489 ..    1276    1493 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 1.1e-05
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXX.XXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXX CS
        DAG1   36 nsstitlksitkgsiiveftnntlklepcpkeqvaglskkildedgsl..reafkrale.Pelkltnisvvgssscrh.....lefiplnqleeiPs 124 
                  +s +it++++  + i + f n tl +++    ++  +  +   ++ +    e+  + le  +l   ni+++ s  c+      ++ i+ n ++   +
  EFC38696.1 1338 SSEKITVQNLE-QPISLSFENVTLTVSSIDTLNISCVYYEENSKEWKSdgMETEIKNLEiHNLADGNITLTLSILCNTnhltsFSVIDQNYKKAATK 1433
                  46678898885.578899*********999999987754443333332112222233332578889*****99999754565566788777666655 PP

                  XXXXXXX...XXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXX CS
        DAG1  125 evastea...peedaeksseddvylhtvipav..vvaailliagiiamicyrkkrk 175 
                  ++++++    p +dae    + v + +++ av  v +++++i+ ii+++c+ +krk
  EFC38696.1 1434 PTPQPAQsnqPTKDAEILQDNTVLIGAIVGAVggVCVIAVVISIIIIVVCLLRKRK 1489
                  55555440014444555555556666777787666777788899999****99998 PP

>> GSDH  Glucose / Sorbosone dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   4.2e-05     0.068       1      65 [.     549     613 ..     549     704 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.2e-05
                 -S-EEEEEE-TTS-EEEEE.TTTEEEEEE..TTEE.EEEEE-.----STT-SEEEEEE-TTTTTS-E CS
        GSDH   1 lehPwslaflpdgrlLvte.rsGrlrlvk.adgklkepiagvpevvakgqgGlldvalhpdfaenrl 65 
                 l +P+++aflp+g+l+++  ++ r+r ++ ++g++ ++iag+  + + +  Gl++va++ ++++   
  EFC38696.1 549 LANPMGIAFLPNGDLIISDaKNNRIRKFSiSSGNV-TTIAGTG-LTTYNGEGLVGVATNINYPTGIC 613
                 579************99863799***999677888.******6.55555679*********987554 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       3.2   5.2e+03      52      74 ..     172     193 ..     168     199 .. 0.82
   2 ?   -0.8   0.2       1.1   1.8e+03      53      78 ..     228     253 ..     223     295 .. 0.73
   3 ?    2.7   0.1     0.091   1.5e+02      32      76 ..     475     518 ..     467     525 .. 0.79
   4 ?    7.2   0.1    0.0036       5.9      36      78 ..     589     631 ..     577     636 .. 0.87
   5 ?    0.4   0.0      0.48   7.8e+02      46      72 ..     989    1015 ..     974    1017 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.2
  Arylesterase  52 glssanGInidadkkyiyvadil 74 
                    ++++  I +++d+  +yv d  
    EFC38696.1 172 TFTAPRCIAVSPDDE-VYVCDAF 193
                   689999******986.8998865 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.1
  Arylesterase  53 lssanGInidadkkyiyvadilresi 78 
                   +ss+  I + +  k ++ +d+l++ i
    EFC38696.1 228 ISSPSSIAFHPITKELFYSDLLANVI 253
                   56677777777777777777776655 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.091
  Arylesterase  32 qlawtavvYyspsevkvvasglssanGInidadkkyiyvadilre 76 
                    ++ +++  y ++  +   ++l+ ++G+ i+++   +y++d+ ++
    EFC38696.1 475 STIAGTISKYTGDGSSAIQAQLNGPTGVAISPNGE-VYISDSSND 518
                   566666777888888888899***********985.899998665 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0036
  Arylesterase  36 tavvYyspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   t+   y+++ +  va  ++ ++GI +++ +  i+ ad  +  i
    EFC38696.1 589 TGLTTYNGEGLVGVATNINYPTGICVNSSNSEIFFADTFNYRI 631
                   5566799999999***********************9887665 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.48
  Arylesterase   46 vkvvasglssanGInidadkkyiyvad 72  
                     +   s ls + G+ i  d ++++v +
    EFC38696.1  989 SNAKSSLLSNPKGLSILNDGRIVFVDS 1015
                    4455667899**************965 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   2.0   3.2e-05     0.052       5      31 ..    1056    1079 ..    1051    1080 .. 0.83
   2 ?    7.3   3.5    0.0035       5.7       6      31 ..    1097    1118 ..    1092    1119 .. 0.85
   3 ?    8.0   5.3    0.0022       3.5       3      31 ..    1142    1166 ..    1140    1167 .. 0.86
   4 ?    7.2   3.2    0.0039       6.3       5      31 ..    1197    1220 ..    1194    1221 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 3.2e-05
                  T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    5 p.CsngGtCvdtgrggytCiCpeGytGk 31  
                  + Cs++G C ++     +C C++Gy+G 
  EFC38696.1 1056 KvCSGNGVCQSLD----SCLCSNGYSGV 1079
                  36*******7777....*********95 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0035
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs++G C ++     +C C++Gy G 
  EFC38696.1 1097 CSGRGVCQSLN----NCSCSMGYYGV 1118
                  *******7777....********995 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0022
                  STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGk 31  
                  +n Cs++G+C ++     +C C +Gy+G 
  EFC38696.1 1142 SNVCSGRGICQSLN----NCSCFTGYSGL 1166
                  566*******7777....*********96 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0039
                  T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    5 p.CsngGtCvdtgrggytCiCpeGytGk 31  
                  + Cs++G+C  +     +C C +Gy+G 
  EFC38696.1 1197 TvCSGRGICQLLN----NCSCFSGYSGL 1220
                  34*******7666....9********96 PP

>> RIFIN  Rifin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   6.1   0.00022      0.36     134     307 ..    1301    1491 ..    1244    1494 .] 0.60

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00022
       RIFIN  134 wkkaalaaaieaaie...ageaagikaviel.lkkllklselkekkleslitatnyknvtslvkaikeeyeescll...........klkkskaalt 215 
                  +k+  ++ + + a++   +++aa i+ +++l l k  + ++++ ++le+ i + +++nvt  v++i +  + sc++            ++++ ++l+
  EFC38696.1 1301 LKNDSVQVVSSIAESknsNSDAAVISSIVSLvLLKSSSSEKITVQNLEQPI-SLSFENVTLTVSSIDTL-NISCVYyeenskewksdGMETEIKNLE 1395
                  556666666666655212222444444433213333334444556666666.789***********999.667777777777766653333333333 PP

       RIFIN  216 sakekekkeasskekikkkvekive.kaekkaaaaaaeaaaeataeaekaetaaveattaslqtaiiasivaivvIvLimvIIYLi...LRYrRKk 307 
                  + +    + + + +  +++ + +    + ++ ++aa++ + + +++ + ++ a++ +  + l  ai+ ++  + vI +++ II ++   LR r+K 
  EFC38696.1 1396 IHNLADGNITLTLSILCNTNHLTSFsVIDQNYKKAATKPTPQPAQSNQPTKDAEILQDNTVLIGAIVGAVGGVCVIAVVISIIIIVvclLRKRKKE 1491
                  333334444444444444433333324445555555566666666667777777888888888888877766666655544444440115555554 PP

>> Syndecan  Syndecan domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   3.0   0.00081       1.3       7      39 ..    1455    1492 ..    1449    1493 .. 0.61

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00081
    Syndecan    7 evlaavigg.....vvvgllfaillvlflvYRmrKKDE 39  
                   vl + i+g     +v+++++ i++++ ++ R rKK E
  EFC38696.1 1455 TVLIGAIVGavggvCVIAVVISIIIIVVCLLRKRKKEE 1492
                  45544443311111456677788899999999999988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1494 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       914  (0.0509789); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.99u 0.33s 00:00:01.32 Elapsed: 00:00:00.52
# Mc/sec: 8684.28
//
Query:       EFC38697.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-28   96.8   0.3    3.5e-11   42.6   0.0    5.4  5  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.6   0.0    0.0015        26      18      42 ..      56      80 ..      51      85 .. 0.90
   2 !   18.8   0.0   5.6e-08     0.001       1      41 [.      86     126 ..      86     132 .. 0.90
   3 !    3.0   0.1    0.0046        82      18      37 ..     190     207 ..     171     212 .. 0.77
   4 !   42.6   0.0     2e-15   3.5e-11       1      46 [.     224     269 ..     224     271 .. 0.97
   5 !   20.4   0.1   1.7e-08   0.00031       1      43 [.     274     316 ..     274     321 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0015
     DUF4116 18 ylseeLknDkeivlkAvkqngtals 42
                +++e+L +D e++ + v++ gtal+
  EFC38697.1 56 KIDERLVRDLEFAFRVVQIEGTALR 80
                58999*****************997 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 5.6e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 +r ++l av++ng+a+ y+   +++D e v+ A   +g+++
  EFC38697.1  86 NRRVALAAVQQNGNAYSYIKGPFQRDLECVMSAALTCGNNI 126
                 67899***************************999999865 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.0046
     DUF4116  18 ylseeLknDkeivlkAvkqn 37 
                 ++s  +++D++ +l+ ++++
  EFC38697.1 190 FAS--FCSDRDALLQLLRNC 207
                 555..9**********9987 PP

  == domain 4  score: 42.6 bits;  conditional E-value: 2e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 D+E+vle v+++g ++++++ +L+ D++i+l Avk++g al +a++
  EFC38697.1 224 DKELVLEMVSRDGISIEHIPRNLQADRDIILTAVKNDGRALMFAHP 269
                 9******************************************985 PP

  == domain 5  score: 20.4 bits;  conditional E-value: 1.7e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 D Eiv+eavk+n   + y+++eLk+ k ++  +++ n   +sy
  EFC38697.1 274 DFEIVTEAVKSNARGFFYVDNELKSSKKFIDMCMRENQEGFSY 316
                 88*********************************88766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       719  (0.0401026); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1931.49
//
Query:       EFC38698.1  [L=152]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.062   12.9   0.3      0.097   12.3   0.3    1.3  1  SipA      SipA N-terminal domain


Domain annotation for each model (and alignments):
>> SipA  SipA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.3   5.4e-06     0.097      32      70 ..       6      45 ..       1      50 [. 0.81

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.4e-06
                HH---HHHHHHHHHHHHHHHHHHHHCTT.-HHHHHHHHHH CS
        SipA 32 snsnnayakkeiiefakvlssllrqtdl.dpeaeklLqkv 70
                +ns+ +y+k  iiefa   ssl++++   +  +  +L+++
  EFC38698.1  6 ENSKKKYSKFSIIEFASSTSSLKKENHKvSNTNSSTLEHL 45
                79********************998864166677777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (152 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1431  (0.0798148); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 923.94
//
Query:       EFC38699.1  [L=541]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.01   15.7   0.1        2.6    8.0   0.0    2.9  2  HNH_5           HNH endonuclease
        2.6    8.0  27.7      0.037   14.1   4.0    2.5  2  Neur_chan_memb  Neurotransmitter-gated ion-channel transmembr
        4.2    7.4   9.0        1.1    9.3   0.0    3.2  3  ADK_lid         Adenylate kinase, active site lid


Domain annotation for each model (and alignments):
>> HNH_5  HNH endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.0   0.00043       2.6      29      51 ..     209     231 ..     202     236 .. 0.81
   2 ?    4.5   0.0    0.0052        31      34      51 ..     323     340 ..     316     344 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00043
       HNH_5  29 isnlvtlCkkCNqkkgqkvdaal 51 
                 ++++ ++C+kCN+ + ++++++ 
  EFC38699.1 209 THSFLMVCSKCNNLFATFIPPKQ 231
                 5666789******9999988775 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0052
       HNH_5  34 tlCkkCNqkkgqkvdaal 51 
                   CkkC  k g+ ++++l
  EFC38699.1 323 LFCKKCGTKVGSILKEPL 340
                 48*********9888876 PP

>> Neur_chan_memb  Neurotransmitter-gated ion-channel transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   4.0   6.1e-06     0.037      64     200 ..      27     183 ..      25     213 .. 0.60
   2 ?   -0.6  15.8      0.19   1.2e+03      91     177 ..     443     525 ..     407     540 .. 0.48

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 6.1e-06
                     HHHHHHHHHHHHHHHHHHHHH-S-S---HHHHHHHTTHHHHHHC--------------.................-------------------- CS
  Neur_chan_memb  64 tmvfvtlsivetvfVlnvhhrsprthtmpawvrkvfldklprllfmkrpsevkdnekkl................ssgasseaeelilskskses 142
                      ++f ++s++   f+ n+ +++ +++tm ++++++    +++    + ++e  ++e+++                s++ ++e++ l  s s+s s
      EFC38699.1  27 LLIFLMMSLIFALFIFNYKKKKTMNNTMIQQIETLDYSSVEEQINDEDDEELINDEDDEveqelskdeellakvsSTQFAKEEDTLNYSISESSS 121
                     579*******************************9999999887777777666666655666677777777666422222222222222222223 PP

                     ------------------SS---TTGGG--.........-----TTTTTHHHHHHHHHHHHH CS
  Neur_chan_memb 143 kkaklseeqgsekastckckckegeeaspstqlsk....eelspelkkavegvkyiadhlra 200
                      ++  +eeq+   + +++ ++++++++s++t+ ++    ++   +++ a+++ +   ++l++
      EFC38699.1 122 DEEIAQEEQPTITEFKQESTTRRTSRNSTNTDEEAhaisSSTTTNIEAAINHNRLLLQQLQN 183
                     33333333333333333333333333333333333333344444455555544444444444 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.19
                     -HHHHHHHTTHHHHHHC--------------.--------------------------------------SS---TTGGG--..... CS
  Neur_chan_memb  91 mpawvrkvfldklprllfmkrpsevkdnekklssgasseaeelilskskseskkaklseeqgsekastckckckegeeaspstqlsk 177
                     + +  ++ f +  p+    +rp+++++++    +++++++ + +++++ + +++++ ++++g++k+++++ ++++++++s++ +++k
      EFC38699.1 443 RGRFPQRKFNNNQPHRRNNQRPKSSNPQQ----QQQQKQQSSQKVQSPPQRTQESTTTNKEGGGKSKKKRSQKRKKKNNSNEPENKK 525
                     33333344444444444444443333222....233333333444444444444454455554444444444444444444444433 PP

>> ADK_lid  Adenylate kinase, active site lid
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.0   0.00019       1.1       2      21 ..     214     232 ..     214     234 .. 0.92
   2 ?    3.0   0.2     0.017     1e+02       1       9 [.     322     330 ..     322     331 .. 0.88
   3 ?   -3.8   1.2       2.2   1.3e+04       4      12 ..     426     434 ..     425     442 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00019
                 EE-TTT--EEETTTB--SST CS
     ADK_lid   2 rvCpkCGrsYhvvfnpPkve 21 
                 +vC+kC+  +  +f+pPk++
  EFC38699.1 214 MVCSKCNNLFA-TFIPPKQD 232
                 59*********.******87 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.017
                 EEE-TTT-- CS
     ADK_lid   1 RrvCpkCGr 9  
                 R+ C+kCG+
  EFC38699.1 322 RLFCKKCGT 330
                 899****95 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 2.2
                 -TTT--EEE CS
     ADK_lid   4 CpkCGrsYh 12 
                 + + +r Yh
  EFC38699.1 426 HHNRNRNYH 434
                 6666899*9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (541 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2919  (0.162809); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                       143  (0.0079759); expected 17.9 (0.001)
Passed Fwd filter:                        34  (0.00189637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.07u 0.31s 00:00:01.38 Elapsed: 00:00:00.51
# Mc/sec: 3191.27
//
Query:       EFC38700.1  [L=625]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0043   17.6   0.0      0.011   16.3   0.0    1.7  1  Ank_2       Ankyrin repeats (3 copies)
     0.0056   17.2   0.0       0.12   13.0   0.0    2.6  2  Ank_4       Ankyrin repeats (many copies)
  ------ inclusion threshold ------
      0.031   14.8   0.1       0.36   11.5   0.0    2.8  2  Ank_3       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   1.8e-06     0.011      27      64 ..     399     444 ..     366     473 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.8e-06
       Ank_2  27 ktaLhyAakngnleivklLleh........adndgrtpLhyAarsg 64 
                  t+LhyA++  n+e+v+lL ++        ++++  +pL +A+r++
  EFC38700.1 399 FTILHYAVSMCNVEMVELLTNKylanpvfeTTYHAVSPLSLAIRNS 444
                 69*******9999*******9778555544448899*******974 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.14   8.3e+02      33      53 ..     336     356 ..     312     356 .. 0.79
   2 !   13.0   0.0     2e-05      0.12      37      54 ..     400     417 ..     394     425 .. 0.72

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.14
       Ank_4  33 rsGetalhiAakrgnveilkl 53 
                 ++G+ + h+A+++ ++  l++
  EFC38700.1 336 SDGFYLQHFAVWIKSIPLLEW 356
                 467777799999999999998 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 2e-05
       Ank_4  37 talhiAakrgnveilklL 54 
                 t lh+A+++ nve+++lL
  EFC38700.1 400 TILHYAVSMCNVEMVELL 417
                 666666666666666665 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0     6e-05      0.36       4      25 ..     400     421 ..     398     426 .. 0.86
   2 ?   -1.9   0.0       1.4   8.5e+03       4      13 ..     435     444 ..     434     446 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 6e-05
       Ank_3   4 tpLhlAarsgnleivkfLlenk 25 
                 t+Lh+A++ +n+e+v++L +++
  EFC38700.1 400 TILHYAVSMCNVEMVELLTNKY 421
                 99**************998755 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.4
       Ank_3   4 tpLhlAarsg 13 
                 +pL lA+r+ 
  EFC38700.1 435 SPLSLAIRNS 444
                 79*****996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (625 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1075  (0.0599587); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.37s 00:00:01.08 Elapsed: 00:00:00.51
# Mc/sec: 3655.62
//
Query:       EFC38701.1  [L=705]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.2e-07   31.2   0.0    2.2e-07   31.2   0.0    2.7  4  Alpha_kinase  Alpha-kinase family
  ------ inclusion threshold ------
       0.14   12.1   0.0         18    5.4   0.1    2.7  2  OmdA          Bacteriocin-protection, YdeI or OmpD-Associated
        1.3    9.1   5.3        1.1    9.3   3.1    2.0  2  DUF1451       Zinc-ribbon containing domain
        9.8    6.5  14.5       0.07   13.4   0.7    3.5  4  PIN_4         PIN domain


Domain annotation for each model (and alignments):
>> Alpha_kinase  Alpha-kinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2   0.0   4.9e-11   2.2e-07     148     184 .]       1      36 [.       1      36 [. 0.98
   2 ?   -2.6   0.1       1.1   5.1e+03      59      79 ..     308     328 ..     266     391 .. 0.67
   3 ?   -3.2   1.7       1.7   7.7e+03      88      88 ..     430     430 ..     339     498 .. 0.61
   4 ?   -3.5   0.1       2.2   9.8e+03      51      80 ..     568     596 ..     557     641 .. 0.45

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 4.9e-11
                   EES-EEE-TT--SS-TT--HHHHHHHHHHHBB--HHH CS
  Alpha_kinase 148 LTDpaIhtkdkkrfgdtnlgeegiakFfetHkCnkic 184
                   +TDpaI +  +  +g+t+ geeg+++Ffe H Cn++c
    EFC38701.1   1 MTDPAISSVGQ-LYGETDTGEEGFKDFFEAHYCNELC 36 
                   6**********.************************9 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.1
                   ......HT--SS--EE---EE CS
  Alpha_kinase  59 akarakekkppkkieflealv 79 
                   ++++ +e+++  +++f ++ +
    EFC38701.1 308 IQDKYYEENKFANFTFSDPSI 328
                   444444444444444444444 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 1.7
                   C CS
  Alpha_kinase  88 k 88 
                   +
    EFC38701.1 430 S 430
                   2 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 2.2
                   HHHHHHHH......HT--SS--EE---EEE CS
  Alpha_kinase  51 kelakeFnakarakekkppkkieflealvl 80 
                   + l++eF+ + +++  ++++++++ +  v 
    EFC38701.1 568 QNLVDEFK-EINVQVPDESNNLTLRTLKVT 596
                   55555565.222222222222332222222 PP

>> OmdA  Bacteriocin-protection, YdeI or OmpD-Associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.1    0.0041        18       6      24 ..     164     182 ..     162     183 .. 0.92
   2 ?    3.7   0.0     0.014        63       1      27 [.     229     255 ..     229     266 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0041
        OmdA   6 edlaaaLdadpaakaaFea 24 
                 e+ + +Ld+dp++k+ Fe+
  EFC38701.1 164 EEMQNQLDKDPDLKKQFEK 182
                 7899*************96 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.014
        OmdA   1 elevPedlaaaLdadpaakaaFealtp 27 
                 elevP  +  +++ +p a +a++ l  
  EFC38701.1 229 ELEVPSTFSIEFENEPIALEAYQILGS 255
                 68********************98754 PP

>> DUF1451  Zinc-ribbon containing domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   3.1   0.00024       1.1     103     130 ..      79     106 ..      73     114 .. 0.88
   2 ?   -3.2   0.0       1.7   7.7e+03      59      80 ..     616     637 ..     610     639 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00024
     DUF1451 103 vyqsGevvglGtlvCekCgkelalkkte 130
                 +y+ Ge +  Gtl C+kC+++ ++++ +
  EFC38701.1  79 EYKIGEKTPDGTLFCNKCNQRNSITEKK 106
                 79*******************9998766 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.7
     DUF1451  59 eeleewlsldlelieeslleal 80 
                 e  ++ +++ l++i++s++++l
  EFC38701.1 616 ELKANADKFRLNVINSSAMNQL 637
                 4345688999999999999887 PP

>> PIN_4  PIN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       0.7   3.1e+03      30      68 ..     142     192 ..     141     213 .. 0.56
   2 ?   -0.4   1.4       0.3   1.3e+03      31     100 ..     395     476 ..     392     513 .. 0.62
   3 ?   -0.3   0.1      0.27   1.2e+03       1      34 [.     523     560 ..     523     573 .. 0.81
   4 ?   13.4   0.7   1.6e-05      0.07      88     125 ..     589     626 ..     557     631 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.7
       PIN_4  30 VleELdklKkgsse............relarlarqanrlldellekesgrl 68 
                 + +EL+  Kk++ +            ++l++     +++ ++++++++++l
  EFC38701.1 142 IASELRDWKKNKTLpngalftqeemqNQLDKDPDLKKQFEKSIIQEKKPDL 192
                 567888888888767666555544443444444444444444444444444 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.3
       PIN_4  31 leELdklKkgsserelarlarqanrlldellekesgrlkvqtsaeelpeee............seseknDnrIlavalelke 100
                 l+E+d lK  ++ +  +++ ++a+++++ ++++e++   + ++  +lp+ +            + ++ n++r+ + a + ke
  EFC38701.1 395 LQEIDLLKLLNQSDIFKKKFNSAKSFMQITFKSEQSAALLIKNGLKLPNFKftinfkkiqeneRSNDCNEKRVQSEAKSKKE 476
                 7888888888887777888888888888887777555444444333332211222222222111234555555555544444 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.27
       PIN_4   1 fVlDTnvlLhdpealksf....keehdvviPitVleEL 34 
                 fV+D n+lL+  ++ + +    +++++ ++P + l+E+
  EFC38701.1 523 FVFDINTLLKIGNLRNLLgqflENHIQFCVPDIKLDEM 560
                 79*******98877665577777777899998888886 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 1.6e-05
       PIN_4  88 DnrIlavalelkeekpdrkvvLvskDinlrikAkalgi 125
                   r l+v+ +++ ++p+r+v+Lv++D++l+  A+   +
  EFC38701.1 589 TLRTLKVTKKVSDNYPNRNVMLVTDDKELKANADKFRL 626
                 456799999***********************998766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (705 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1511  (0.0842769); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 4008.74
//
Query:       EFC38702.1  [L=502]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-17   64.4   0.3    2.3e-17   63.4   0.3    1.5  1  Peptidase_M20  Peptidase family M20/M25/M40
    3.6e-06   26.9   0.0    7.8e-06   25.8   0.0    1.6  1  M20_dimer      Peptidase dimerisation domain


Domain annotation for each model (and alignments):
>> Peptidase_M20  Peptidase family M20/M25/M40
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.4   0.3   2.6e-21   2.3e-17       1     206 [.      78     496 ..      78     497 .. 0.86

  Alignments for each domain:
  == domain 1  score: 63.4 bits;  conditional E-value: 2.6e-21
                    EEEEES-BSS.TTCG..GGSSS.TTSEE..ETTT.EEESTTTTTTHHHHHHHHHHHHHHHHHTTT-SSEEEEEEESTTSSTTTHHHHHHH...... CS
                    xxxxxxxxxx.xxxx..xxxxx.xxxxx..xxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...... RF
  Peptidase_M20   1 llgsHlDvVp.eeet..dgwtt.pfslt..eedG.klyGrGaddmkggvlaalealralkdegikpkgtivllfqpdEEggrgGakalle...... 83 
                    ++++H+D+V+ +++t   +++t p +l   ++ G  +++ G++ +    +++   l+   d+ +   g+i+ll++ dEE+g++G  al        
     EFC38702.1  78 AIQGHIDMVCeKNKTtqHDFDTdPITLIrsQD-GdWIHADGTTLGSDNGIGVCCGLALATDKDVV-HGPIELLLTIDEETGMSGVMALKPefctak 171
                    589*******7444423336667777779555.55*******************99777777655.7************88888866665665577 PP

                    .HHH.TTTCESEEE.EEEEESSSBTCHSTETEEEE............................................................. CS
                    .xxx.xxxxxxxxx.xxxxxxxxxxxxxxxxxxxx............................................................. RF
  Peptidase_M20  84 .gle.erekvdavf.elhieepgileagklaigvv............................................................. 115
                      l  ++e++ a++ ++  ++ +  +     + +v                                                             
     EFC38702.1 172 yLLNlDAEELGAFYvGCAGGQDTTAS-----FDIVeeelvdsssfeqvsimvsglkgghsgidihtgrgnaikllartlkhvldevpsdnlkvfyi 262
                    63344477788777344444444444.....44555566699999999999999999999999999999999999999999999999999999999 PP

                    ................................................................................................ CS
                    ................................................................................................ RF
  Peptidase_M20 116 ................................................................................................ 115
                                                                                                                    
     EFC38702.1 263 eagskrnaipreawvnayvkkdkleavkervaafeklavsefsvpepnlkisvgpvesattstkvfaseflsklisvifavphgvfqmspvieglv 358
                    999999999999999999999999999999999999999999999999999999****************************************** PP

                    ............................................EEEEEEEEEESHEEEC.CHHHHHHHHHHHHHHHTSCEEEEEESSSBHTHHHH CS
                    ............................................xxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M20 116 ............................................kvevelleggapvtln.dsplvkalaeaaeelfgekvelivsgpggtdarff 166
                                                                 ++v++  g+  +  + +spl k+++++++e ++ ++e ++ + +g +++ +
     EFC38702.1 359 etstnlaivntrdgkiefctsqrssvnsaknyaahsvasvfalsGADVKHSDGYVGWQPDmNSPLLKLCKDVYTEKYKATPEIKAIH-AGLECGLL 453
                    *******************************************66****8899999**99***************776557777888.******** PP

                    TTT.EEE.EE.EESSGGCTTSTTTEEEHHHHHHHHHHHHHHHH CS
                    xxx.xxx.xx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_M20 167 agi.ptv.mi.fgpgsglaHspnEyvdledlekgikvlarlle 206
                    +++ p++ mi +gp   +aHsp+E+v+++d++  +++  ++le
     EFC38702.1 454 LETyPNMhMIaYGPTIVGAHSPDEKVRIADVAHTYELTSAILE 496
                    6666*888888**99999**************99998887775 PP

>> M20_dimer  Peptidase dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.8   0.0   8.7e-10   7.8e-06       4     101 ..     219     300 ..     216     305 .. 0.92

  Alignments for each domain:
  == domain 1  score: 25.8 bits;  conditional E-value: 8.7e-10
                 -EEEEEEEEEE-B-EEGG-TTTTB-HHHHHHHHHHCSCTTEEC.....TCCTCCCCCEECCE-CCCCEESSEEEEEEEEEHHHHHHHHHHHHHHHHHH CS
   M20_dimer   4 kGlaggkitvkgkagHsgapgagaNAieklarllaeledeegdiaeerslprttlnvtgiegGsaknvipdeaeakidiRllpgedpeevleeieeil 101
                  Gl gg+++++++ g+++       Ai++lar l +  de         +p  +l v  ie+Gs++n+ip+ea ++  +   + e ++e  +++e+++
  EFC38702.1 219 SGLKGGHSGIDIHTGRGN-------AIKLLARTLKHVLDE---------VPSDNLKVFYIEAGSKRNAIPREAWVNAYVKKDKLEAVKERVAAFEKLA 300
                 588999999999999999.......***************.........999****************************999999999999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       493  (0.0274974); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 3183.12
//
Query:       EFC38703.1  [L=1616]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.6e-42  143.9  16.6    7.7e-42  143.2  16.6    1.3  1  Peptidase_M50B  Peptidase M50B-like
    1.5e-32  112.8  11.1    5.2e-19   68.3   2.1    3.5  4  HPS3_Mid        Hermansky-Pudlak syndrome 3, middle region
    0.00011   21.8   2.3       0.16   11.5   1.5    2.9  2  HPS3_N          Hermansky-Pudlak syndrome 3
  ------ inclusion threshold ------
      0.065   13.3   0.0       0.22   11.6   0.0    1.9  1  RNase_P_pop3    RNase P subunit Pop3


Domain annotation for each model (and alignments):
>> Peptidase_M50B  Peptidase M50B-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.2  16.6   1.7e-45   7.7e-42       2     199 ..    1390    1602 ..    1388    1603 .. 0.91

  Alignments for each domain:
  == domain 1  score: 143.2 bits;  conditional E-value: 1.7e-45
  Peptidase_M50B    2 laivlalvvlwnk....pllrpfkllvvffHElGHalaalLtGgrvkgielhsdesGvtvtrg..pgglgqiltllaGYlgpallGlllills 88  
                      ++iv++l++ +++    ++ +pf+++ +f+HE+GHa+ alL+G+++k i ++s++sG+tv++   +++++++++++ G+lgp+++G+l+i+ls
      EFC38703.1 1390 ASIVTVLIWQLPSdvgrYIAYPFTIFGTFWHEMGHATSALLCGNSLKYIIIESNGSGLTVYADyaDSRICNAIISVNGPLGPTFFGCLIICLS 1482
                      567788888888899999*********************************************9999************************99 PP

  Peptidase_M50B   89 ..asgka...rlllv..llvllllvllllvrnlfglvlllllgallllvlllaedelleflllflgvflllgsvrdiddlirrkapesDasql 174 
                        + ++    r+ll+  +++++++++ll++++lfg+++l +l+++ll+++++a+ ++l+f l+f+gv+++++++++i++l+++++ +sD+  +
      EFC38703.1 1483 vlFVKHEifsRILLGliSVIVFVCTVLLVRKSLFGIIFLPCLAVILLVMSVKANGKILTFSLQFIGVQMAISMYQNILYLFSKMDGKSDTGSV 1575
                      775555557889998545556677778888*************************************************************** PP

  Peptidase_M50B  175 akltg..vpallwvvlwllvslaflal 199 
                      + l++  vp+++ ++++++v+++++++
      EFC38703.1 1576 EVLFNglVPYWMVAIFIIIVNVILILV 1602
                      *****8888888889999999998876 PP

>> HPS3_Mid  Hermansky-Pudlak syndrome 3, middle region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.2   3.2e-10   1.4e-06      77     145 ..     441     509 ..     420     514 .. 0.91
   2 !   21.9   0.0   1.4e-08   6.1e-05     172     206 ..     514     548 ..     510     589 .. 0.73
   3 !   68.3   2.1   1.2e-22   5.2e-19     215     389 .]     596     780 ..     577     780 .. 0.88
   4 ?   -4.1   0.0       1.1   5.1e+03     181     202 ..    1546    1568 ..    1543    1572 .. 0.82

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 3.2e-10
    HPS3_Mid  77 ksvlesekkeelkslfCFfslpqegYLYslkdavellstYqYpekvkqvvltdqfLhviTrngLecftv 145
                 ++  +++++++ +++ C +s+ + gY Y l++ ++ll  ++Y+ +    +++  fL++iT  gLe ++v
  EFC38703.1 441 QNIAQKRDFNQNTGMKCILSTSTCGYVYGLSSPQQLLCEFEYTGECLMSAVNSLFLYAITPVGLEIWSV 509
                 577888999999*****************************************************9988 PP

  == domain 2  score: 21.9 bits;  conditional E-value: 1.4e-08
    HPS3_Mid 172 dvcalrlqlFiglkalchfknhviLlskadseaee 206
                 + c+lr ++Figlk+++ +++hviLlsk  s+++ 
  EFC38703.1 514 NGCLLRFHPFIGLKNVSATDKHVILLSKMSSNENV 548
                 56**************************9864443 PP

  == domain 3  score: 68.3 bits;  conditional E-value: 1.2e-22
    HPS3_Mid 215 srkktsskskeksesesgwnLYvvntvsilqlykemveyskryknespqsyihlLseahlLlraalldqslekseeke................eLkea 297
                  +k++ +++ ++  +e ++n+Y++n v++ ++y++m+e +  yk++ +  y++lL+e h Ll+++ ++  +++++  +                +   +
  EFC38703.1 596 RKKEEPKSTAQPVVEEFSYNIYALNSVELCEIYEDMLEHAIMYKTQDNAKYMKLLKESHSLLQSKYFELLAKEKKLDRpetdpviilktrvdlqNYTTL 694
                 4566667888999999*************************************************99866666666558899*********9999999* PP

    HPS3_Mid 298 fkescalLgdcysrldekdshlalpYYkmSglsvteiikrikalkesakdsyerGllfylkhaLl....eeteeelsketadkvleifsqaepeqL 389
                 +k s +l+gd+y+++   +++ a+  Y+ S   + ++ +      ++        ll +l+h+L+    ++ e+  s+e++dk+l+i+ q  p+ L
  EFC38703.1 695 LKRSFGLIGDTYVSAG--QIDKAAYAYSNSDRPIDNVFEN--LSVREE------SLLLFLDHVLFdndiSNMEKVCSEELGDKILSIYRQRTPHRL 780
                 ************5555..799999999**********998..333444......49*********9999999******************999876 PP

  == domain 4  score: -4.1 bits;  conditional E-value: 1.1
    HPS3_Mid  181 Figlk.alchfknhviLlskads 202 
                  Fig++ a+++++n + L+sk d 
  EFC38703.1 1546 FIGVQmAISMYQNILYLFSKMDG 1568
                  8998746999**********995 PP

>> HPS3_N  Hermansky-Pudlak syndrome 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0   0.00045         2       7      79 ..       8      84 ..       3      93 .. 0.81
   2 !   11.5   1.5   3.6e-05      0.16     134     210 ..     184     250 ..     179     251 .. 0.91

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00045
      HPS3_N  7 nFksqevvsveqeptavcaag.dkLlvatesgcvevydlee..eeckvlcrf.stvdkvlkiaysesGdyvatlEek 79
                 F+sq+++  +   +  c a  d+L+ ++ +g+v  y+ ++  +e++ l++f +  ++v +i y      v+t+E++
  EFC38703.1  8 VFQSQDILCPHDLGQPYCSAAsDSLFWVAYNGIVKGYSTQTtqKEFHCLYEFqPLWNQVDAIHYLPDIRRVITVERR 84
                69*****99986555556555799**99999*******6654589999999944679*******9999999999987 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 3.6e-05
      HPS3_N 134 ptciacCqvtgnllvgvkkklslfrlkvktqdiselkllDfeelllllelkfvpkqvaicedyvAvmselevkvlkl 210
                   +i+ C  + +ll  vk+++sl+++            +D    +l+l++++++k +++ ++++++ + ++v+v++l
  EFC38703.1 184 ELLISVCTYSNQLLTCVKDVISLWKFTN----------HDTSVCVLKLHTSWNVKCISVFNQFIGYGTTKDVRVVEL 250
                 5689**********************99..........466778899****************************98 PP

>> RNase_P_pop3  RNase P subunit Pop3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   4.9e-05      0.22      43     118 ..    1074    1148 ..    1061    1158 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.9e-05
  RNase_P_pop3   43 vrlles.keneeseltvglneivelLecsesddvvllvcnkDtPsvLlsqlpllvavanltvklvqlpksaqaklde 118 
                     + ++s  + + + l   +n+++ +Le    +d+ l+ +++ +P +L+ +  ll   + l +  vql     + ++e
    EFC38703.1 1074 EKNRDSfGNVNSKTLSEKYNDVNSILESISMADATLFSLTENDPFLLMIH--LLYSAQGLICFFVQLLSGNGDLFQE 1148
                    566675356677788999*********8888888888877777****977..5777778889999998888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1616 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1192  (0.0664845); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.05u 0.29s 00:00:01.34 Elapsed: 00:00:00.49
# Mc/sec: 10018.94
//
Query:       EFC38704.1  [L=719]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-30  104.9   0.3    7.8e-30  103.5   0.3    1.8  1  ABC1      ABC1 family
    0.00062   19.4   0.7     0.0012   18.5   0.1    1.7  2  RIO1      RIO1 family
     0.0014   18.1   0.3     0.0042   16.5   0.3    1.8  1  Pkinase   Protein kinase domain


Domain annotation for each model (and alignments):
>> ABC1  ABC1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.5   0.3   1.3e-33   7.8e-30       2     119 .]     301     427 ..     300     427 .. 0.81

  Alignments for each domain:
  == domain 1  score: 103.5 bits;  conditional E-value: 1.3e-33
        ABC1   2 elgkkleeiFaefdeePiAaASiaqVhrAklksgeeVavKvqrpgvkkriksDlellkllakllkkflkelr..ldleelv.......defskslleEl 91 
                 ++gk+lee+F ef++ePiA+ASiaqVhrA++k+g  VavK+q+p v++ + +D+e+  ++ k   ++   ++  +++++lv       +e+++ l+ El
  EFC38704.1 301 DFGKPLEELFIEFEKEPIASASIAQVHRARTKDGTLVAVKIQYPYVRRFFFNDMETNDIANKFSINVYYLQDdaENIDALValnnkfnEELKDGLYTEL 399
                 79****************************************************9877666654333322223345555442222222577788899** PP

        ABC1  92 dferEAknaekfrenfaklkevkvPkvy 119
                 +f++EA+na k++ n++k k++++Pkvy
  EFC38704.1 400 NFLHEANNATKAAANMKKRKDIYIPKVY 427
                 ***************************8 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0      0.98   5.8e+03       2      22 ..     326     346 ..     325     363 .. 0.74
   2 !   18.5   0.1     2e-07    0.0012      55     142 ..     408     495 ..     387     514 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 0.98
                 EEEEEETTTEEEEEEEE-S-- CS
        RIO1   2 VyhavsedgkevaiKiyktst 22 
                 V  a+++dg+ va+Ki    +
  EFC38704.1 326 VHRARTKDGTLVAVKIQYPYV 346
                 788999999999999975444 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 2e-07
                 HHHHHHHHHHHHHTT--S--EEE..EETTEEEEE--EETTEEGGBHHHCG.-HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETT CS
        RIO1  55 aekEfrnLkrleeagvpvPkpie..lkrhvlvmefigedgvaapklkdve.eeeeaeelyeevleemrklykeaglvHaDLSeyNvlvded 142
                 a+k  +n+k+   +++ +Pk++     + vl mefi+ + v+a +++ ++ +    +++ + +l++    +  +gl H+D    N+lv ++
  EFC38704.1 408 ATKAAANMKKR--KDIYIPKVYSdlTSSRVLTMEFIE-NAVKADNVEAIRkMGFSESDISKRILKSFSEQIMVHGLFHCDPHPSNILVRQN 495
                 45555555543..4579***995447899********.9**********955788899*******9999999***************9987 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.3   7.1e-07    0.0042      64     151 ..     424     518 ..     369     532 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 7.1e-07
                 EEEEEE.SSEEEEEEE--TTEBHHHHHH..HHSS--HHHHHHHHHHHHHHH.HHHHHTTEE-SS-SGGGEEEETTTE......EEE-SGTTSEESSSS CS
     Pkinase  64 yevfee.kdelylvleyveggeladlle..rkgslseeeakkiakqilegl.eylHskgiiHrDlKpeNiLidekge......lKitDFGlakeless 151
                  +v+++ +++++l +e++e+   ad +e  rk+ +se++++k   +il+++ e +  +g++H+D  p+NiL+ ++ +      + i D Gl ke++ +
  EFC38704.1 424 PKVYSDlTSSRVLTMEFIENAVKADNVEaiRKMGFSESDISK---RILKSFsEQIMVHGLFHCDPHPSNILVRQNPKnpsepqIVILDHGLYKEIDDD 518
                 344444678999*******99989988888889999988764...4444442577889***************7555677888********9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (719 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1244  (0.0693848); expected 358.6 (0.02)
Passed bias filter:                      435  (0.0242624); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.29s 00:00:01.04 Elapsed: 00:00:00.48
# Mc/sec: 4459.31
//
Query:       EFC38705.1  [L=232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       569  (0.0317363); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1444.52
//
Query:       EFC38706.1  [L=121]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00048   20.2   0.0    0.00068   19.7   0.0    1.3  1  SAM_2            SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
       0.11   12.9   0.0       0.59   10.6   0.0    1.9  2  Acylphosphatase  Acylphosphatase


Domain annotation for each model (and alignments):
>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.0   7.6e-08   0.00068       2      52 ..      21      71 ..      20      85 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 7.6e-08
                GGHHHHHHHHHHHHTTT.GGGHHHHHHTTCSHHHHHTTSCHHHHHHTTHHHH CS
       SAM_2  2 eswsledvaeWLrsigl.kqytdnFrdagitgaelllrlteedLkrlGitsv 52
                 +w++++ aeWL + ++ k + ++ ++ag++g  +l ++  +dL + ++  +
  EFC38706.1 21 NTWTVNNFAEWLTRERYnKTVIQAITKAGFDG-GALMNFHIDDLVDSKVPEP 71
                58******************************.8888*******87777655 PP

>> Acylphosphatase  Acylphosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.12   1.1e+03      46      69 ..      21      45 ..      15      60 .. 0.70
   2 ?   10.6   0.0   6.5e-05      0.59      23      47 ..      88     113 ..      81     118 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.12
  Acylphosphatase 46 eeekvekfleelksgppk.arvdev 69
                     ++ +v+ f e+l+++  +   ++ +
       EFC38706.1 21 NTWTVNNFAEWLTRERYNkTVIQAI 45
                     5567899999999865554666555 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 6.5e-05
  Acylphosphatase  23 kelg.lkGyvrNlsdgsVeivaegee 47 
                       ++g l+Gyv N+  + V +vae ++
       EFC38706.1  88 SQMGiLHGYVANDGSDMVVVVAETTT 113
                      566669***************99865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (121 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       562  (0.0313459); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.40u 0.24s 00:00:00.64 Elapsed: 00:00:00.39
# Mc/sec: 937.21
//
Query:       EFC38707.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.7e-82  275.5   0.1    5.4e-82  275.3   0.1    1.0  1  Aldo_ket_red  Aldo/keto reductase family


Domain annotation for each model (and alignments):
>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  275.3   0.1     3e-86   5.4e-82       1     292 [.      15     342 ..      15     344 .. 0.94

  Alignments for each domain:
  == domain 1  score: 275.3 bits;  conditional E-value: 3e-86
                   .EEEE-SSS-ST.....TS-HHHHHHHHHHHHHTT--EEE--TT-TTTHHHHHHHHHHHH-TTTGGG-EEEEEE...............--SSSTTS CS
  Aldo_ket_red   1 elglGtwqlgsk....eeiskeealellrraleaGinffDtAevYgkgqseellGealkksrkkreeviiatKv...............dlrdaeik 78 
                   +++lG +++gs+    ++ +++e+  +l++a e GinffDtA++Y +g+se++lG+++ +++ +reev+iatKv                ++++ + 
    EFC38707.1  15 KICLGCMSFGSPkwfdWVLEESESMIILKKAWELGINFFDTANIYSNGESERILGKFIRENNIPREEVVIATKVfgpvdksgeqrllllSDDKKVNT 111
                   69*********************************************************************************************** PP

                   SSS-HHHHHHHHHHHHHHHT-S-EEEEEE-S--TTS-.HHHHHHHHHHHHHTTSEEEEEEES--HHHHHHH....HHTTT--EEEEE-B-BTT-HHH CS
  Aldo_ket_red  79 sglskeniresleeslkrLgtdyvDllllHrpdpslpsieevldaleelvkeGkiraiGvSnfsveqleka....kkkkkvkivavqveynllrele 171
                    gls+++i++++eesl+rLgtdy+Dl+ +Hr+dp++p iee++++l++lvk+Gk+r+iG S+  ++q  ka     kk+ +k+++ q+ y+ll ++e
    EFC38707.1 112 HGLSRKHIMHAVEESLERLGTDYIDLYIIHRWDPDTP-IEETMETLHDLVKSGKVRYIGASSMFAWQFAKAqhyaDKKGLTKFISMQNLYHLLYREE 207
                   *************************************.***********************999999999999999********************* PP

                   HTTHHHHHHHTT-EEEEBSTTGGGTTGTTTSS---SSSCCC-------..............TS-HHHHHHHHHHHHHHHHTT--HHHHHHHHHTTS CS
  Aldo_ket_red 172 eegllelckkkgvpliaysplggGlltgkyqseedkedkeprkdlkrd..............ertsknldaaeelselakehgvslaqlalryalsq 254
                   e+ ++++c +++v l +yspl++G+l +  +  ++ ++ + ++d +++                t++  + ++++sela++++vs+aq+a++++l++
    EFC38707.1 208 ERDMIPMCLDQKVSLTPYSPLAKGILARAHEFVNSEKTSNDEDDDEKSkransdfiqkqfkeTMTEGDKENLRRVSELANKKNVSPAQIAIAWLLKK 304
                   **************************98765443333333333222224458899******999999****************************** PP

                   TT-SEEEE--SSHHHHHHHHGGGG----HHHHHHHHHH CS
  Aldo_ket_red 255 pavgivipgasnieqlednldalelklseeevaeldel 292
                   p+v+++i+ga++++ +e +++al+++l++eev++lde 
    EFC38707.1 305 PGVTSPIVGATKVSNIESSIAALDIELTPEEVKYLDES 342
                   ***********************************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       872  (0.0486363); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.24s 00:00:00.81 Elapsed: 00:00:00.42
# Mc/sec: 2512.58
//
Query:       EFC38708.1  [L=189]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-06   26.5   0.1    8.3e-05   22.5   0.0    2.4  2  Thioredoxin  Thioredoxin
  ------ inclusion threshold ------
      0.095   12.8   1.0       0.18   11.9   1.0    1.4  1  TssO         Type VI secretion system, TssO
        2.3    8.5   6.0          7    7.0   6.0    1.9  1  Wzz          Chain length determinant protein


Domain annotation for each model (and alignments):
>> Thioredoxin  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.1     0.068   4.1e+02      63      88 ..      96     121 ..      90     129 .. 0.81
   2 !   22.5   0.0   1.4e-08   8.3e-05       3      47 ..     132     175 ..     130     186 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.068
                  HHHHHTT-SSSSEEEEEETTEEEEEE CS
  Thioredoxin  63 dlakkyevegiPtlklfkngkevkky 88 
                    a++ +ve  Pt  + k+++e +++
   EFC38708.1  96 PAAANKQVEEKPTTTIQKEEEEHEDL 121
                  5677889*******999999988776 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 1.4e-08
                  EESSHHHHHHHHTTTSSEEEEEEE-TTSHHHHCHHHHHHHHHHHC CS
  Thioredoxin   3 lvltkenFeeevakekklvlveFyApwCghCkalaPeleklaeel 47 
                  + l+ e++++ +++ + + lv  ++p C hC ++aP++ekl  el
   EFC38708.1 132 QDLSGETYDDFIKS-SPNALVYVFSPSCSHCIQFAPTFEKLVVEL 175
                  6788999*****99.9************************98776 PP

>> TssO  Type VI secretion system, TssO
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   1.0   2.9e-05      0.18       8      60 ..      14      67 ..       8      72 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.9e-05
        TssO  8 sgflyflllFlvtvlllflivffffkssplqekeil.lkelerkkkfeekqkel 60
                s f  +++l +v+++l++l+  f+ +s+p++ +++     le++++ +++q+e 
  EFC38708.1 14 SLFKRLVILTIVVSVLIYLAFTFSLFSVPTKFQKQAlSTTLEANSAKQQQQQEA 67
                55778999999*******************988888799999999999888875 PP

>> Wzz  Chain length determinant protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   6.0    0.0012         7      11      54 ..      14      58 ..      12     150 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0012
                XXXXXXXXXXXXXXXXXXXXXXXX.XXXXX-EEEEEEEES--CHH CS
         Wzz 11 vLwkrkklIilvtllfallaviya.flatpkYtataqilvpekkq 54
                 L+kr +++ +v+ + + la++++ f ++ k++ +a+ +  e ++
  EFC38708.1 14 SLFKRLVILTIVVSVLIYLAFTFSlFSVPTKFQKQALSTTLEANS 58
                79**********************999******988766555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (189 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1752  (0.0977188); expected 358.6 (0.02)
Passed bias filter:                      934  (0.0520944); expected 358.6 (0.02)
Passed Vit filter:                        86  (0.0047967); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1243.46
//
Query:       EFC38709.1  [L=763]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (763 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1532  (0.0854482); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.90u 0.31s 00:00:01.21 Elapsed: 00:00:00.50
# Mc/sec: 4611.40
//
Query:       EFC38710.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0033   17.3   0.0      0.048   13.5   0.0    2.2  2  DUF5408   Family of unknown function (DUF5408)
  ------ inclusion threshold ------
      0.061   12.2   0.1      0.095   11.5   0.1    1.2  1  TRI5      Trichodiene synthase (TRI5)


Domain annotation for each model (and alignments):
>> DUF5408  Family of unknown function (DUF5408)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.04   3.6e+02      22      49 ..       7      34 ..       3      40 .. 0.88
   2 !   13.5   0.0   5.4e-06     0.048      13      32 ..     104     123 ..      95     131 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.04
     DUF5408 22 itlllallslyvLlnqvsAtAalskeik 49
                + l +++l   + l+q+  t a+ ke +
  EFC38710.1  7 ASLFFSILGGLMTLDQIRRTLAIRKEWR 34
                5788999999999**********99976 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 5.4e-06
     DUF5408  13 vkiALvCvvitlllallsly 32 
                  + AL+C + tl+la +sl 
  EFC38710.1 104 FRYALFCSFSTLILASISLA 123
                 578**************995 PP

>> TRI5  Trichodiene synthase (TRI5)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   1.1e-05     0.095     115     172 ..      81     147 ..      64     154 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1.1e-05
        TRI5 115 likGreqkhpfwallnehlpnllrhygsfcaln..i...lrstldffe....GcwieqynfgGfpGs 172
                 li  ++ +h +w l n+   +    y  fc+++  i   +  ++ +f+    G  ie+ n++G pG 
  EFC38710.1  81 LIWTQPLAHNYWCLRNTAKGRSTFRYALFCSFStlIlasISLAMGYFQvggfGVGIENDNLEGVPGN 147
                 67778899*************9999*****996322111344799**98777789**********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       573  (0.0319594); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.45
# Mc/sec: 1685.78
//
Query:       EFC38711.1  [L=578]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (578 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2415  (0.134698); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.90u 0.38s 00:00:01.28 Elapsed: 00:00:00.54
# Mc/sec: 3247.81
//
Query:       EFC38712.1  [L=413]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (413 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       837  (0.0466841); expected 358.6 (0.02)
Passed bias filter:                      520  (0.0290033); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.35s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2408.49
//
Query:       EFC38713.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.8e-17   62.4   0.1    6.5e-17   61.3   0.1    1.5  1  PUB           PUB domain
    0.00033   20.2   4.6    0.00033   20.2   4.6    1.6  2  LRRFIP        LRRFIP family
     0.0018   17.9  13.2     0.0026   17.4  13.2    1.2  1  SR-25         Nuclear RNA-splicing-associated protein
      0.009   15.9   0.8      0.016   15.1   0.8    1.4  1  Folliculin    Vesicle coat protein involved in Golgi to plasm
  ------ inclusion threshold ------
      0.028   14.0   0.2      0.036   13.6   0.2    1.1  1  Pro_dh        Proline dehydrogenase
      0.088   11.6   5.4       0.15   10.9   5.4    1.3  1  Med12-LCEWAV  Eukaryotic Mediator 12 subunit domain


Domain annotation for each model (and alignments):
>> PUB  PUB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.3   0.1   2.2e-20   6.5e-17       8      73 ..      47     110 ..      45     118 .. 0.91

  Alignments for each domain:
  == domain 1  score: 61.3 bits;  conditional E-value: 2.2e-20
         PUB   8 lktLrkylnNilehpteekyrrIrleNkafkekvlplegavelLealGFeekneeeeeflvleees 73 
                 l+++  +++Ni++hp+eek+r+I+++N++f + v  +egav+lL ++GFe+   ++ e+++l++e+
  EFC38713.1  47 LQLISSICTNIVTHPNEEKFRKIKIANPKFNDFVMGVEGAVNLLMLCGFEID--DSGEYIILKKEN 110
                 678999********************************************96..788899998876 PP

>> LRRFIP  LRRFIP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       0.5   1.5e+03      95     105 ..      63      73 ..      59      77 .. 0.85
   2 !   20.2   4.6   1.1e-07   0.00033     184     284 ..     127     220 ..     104     227 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.5
      LRRFIP  95 eEkyrKAmvsn 105
                 eEk+rK  ++n
  EFC38713.1  63 EEKFRKIKIAN 73 
                 9*****99988 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 1.1e-07
      LRRFIP 184 eeeatdgekeeesssssksalvskeaaellesagegtldvrLkklaeekeeLleeveklkqqleeekskksssasseelegeeeendleiqreanklis 282
                 ++++  + ++ +ssss++s +v   + +  +s++++  ++r kk++eek++++ e+ k+kqql + k+++++      + +++     + +  ++k++ 
  EFC38713.1 127 TKNNLTTPQKPSSSSSASSSVVK-PTGS-SSSVSDAEIEERKKKMMEEKKKIQAEKDKIKQQLLADKEERKHLPTGVCSRKTT-----KPNSTSKKTFR 218
                 33444444444444444444444.4333.578899*****************************9998776655444333333.....23344444444 PP

      LRRFIP 283 dy 284
                 d+
  EFC38713.1 219 DI 220
                 44 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4  13.2   8.6e-07    0.0026      61     127 ..     134     194 ..     110     219 .. 0.46

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 8.6e-07
       SR-25  61 rrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkakekakaeaaaa 127
                   ++ sssss+sss   +++ssss+sd + ++ kkk+  +kkk +  +k k k++      a++++ 
  EFC38713.1 134 P-QKPSSSSSASSSVVKPTGSSSSVSDAEIEERKKKMMEEKKKIQ-AEKDKIKQQ----LLADKEER 194
                 2.2223333333333333444444444433333333333333332.111122221....22222222 PP

>> Folliculin  Vesicle coat protein involved in Golgi to plasma membrane transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.8   5.3e-06     0.016      78     162 ..     102     189 ..      89     197 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 5.3e-06
  Folliculin  78 erlllkawsfiveafeklaaeiqalaeaelereskeeeassaassssa.....lkadgsglsrregssfslskekylrrsksklkarsLa 162
                 e ++lk+ +f+++ +++l+a i  + +++l + +k +++ssa+ss  +     +  + s ++ +e+++  ++++k  +++k+k+k++ La
  EFC38713.1 102 EYIILKKENFVASDLKDLIAAIDIKTKNNLTTPQKPSSSSSASSSVVKptgssS--SVSDAEIEERKKKMMEEKKKIQAEKDKIKQQLLA 189
                 678999************************998886665555555544776442..3333333333444556677778888888777776 PP

>> Pro_dh  Proline dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.2   1.2e-05     0.036      36     110 ..     115     201 ..      92     222 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.2e-05
                 HHHHHHHHHHHHHC...CS-T.......TCC-SEEE-GGG..TT-SGGGHHHHHHHHHHHHHHHHHHHHHTT-EEEE----GGGHH..H CS
                 xxxxxxxxxxxxxx...xxxx.......xxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..x RF
      Pro_dh  36 ayleaiksiekask...alkv.......leapgvsvklsa..prletaeeeevmeelverlrtlakeakelgvrlliDaEeaklqe..l 110
                 +++++i++i+ ++k   +  +        +a + +vk+++  ++++ ae ee+ ++++e+ +++ +e  + + +ll D Ee k ++  +
  EFC38713.1 115 DLKDLIAAIDIKTKnnlT--TpqkpsssSSASSSVVKPTGssSSVSDAEIEERKKKMMEEKKKIQAEKDKIKQQLLADKEERKHLPtgV 201
                 445555555333321122..122344434444488999998889999999*********************************999443 PP

>> Med12-LCEWAV  Eukaryotic Mediator 12 subunit domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   5.4   5.1e-05      0.15     348     439 ..     119     209 ..     115     221 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 5.1e-05
  Med12-LCEWAV 348 LiSRGdlasessatlnkpakspaeeseeeveekeeelvseidlkakkleekeelddskidddldkllqhikeeqqnsldaPdspkaeakaet 439
                   Li   d++++++ t++++ +s++++++++v + + + +s  d + +++++k+  +++ki+ + dk+ q++  +++++ + P  + +++++++
    EFC38713.1 119 LIAAIDIKTKNNLTTPQK-PSSSSSASSSVVKPTGSSSSVSDAEIEERKKKMMEEKKKIQAEKDKIKQQLLADKEERKHLPTGVCSRKTTKP 209
                   777778999999876555.567777777788888888888899999999999999**********************999998884444332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2247  (0.125328); expected 358.6 (0.02)
Passed bias filter:                      827  (0.0461264); expected 358.6 (0.02)
Passed Vit filter:                       101  (0.00563333); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.53u 0.34s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 1532.40
//
Query:       EFC38714.1  [L=1325]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.6e-10   39.3   8.8    1.1e-09   38.6   6.6    2.5  3  RGS              Regulator of G protein signaling domain
      3e-06   27.7   4.8    6.3e-06   26.6   4.8    1.6  1  GPS              GPCR proteolysis site, GPS, motif
  ------ inclusion threshold ------
       0.59   10.4   2.5        5.7    7.2   0.2    2.6  2  Bac_DNA_binding  Bacterial DNA-binding protein


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.49   2.9e+03      28      56 ..     632     659 ..     629     699 .. 0.65
   2 ?   -3.1   0.0       1.5   9.2e+03      24      38 ..     911     925 ..     892     971 .. 0.77
   3 !   38.6   6.6   1.9e-13   1.1e-09       2     116 ..    1183    1306 ..    1182    1308 .. 0.95

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.49
                 HHHHHHHHHHHTSSHHHHHHHHHHHHHHH CS
         RGS  28 lsFwlaveefkkakeqeelkkkakeIyne 56 
                 ls w++v++fk++ + + +k   ++I++ 
  EFC38714.1 632 LSSWMKVSQFKSK-TASLVKMLSTSIVDS 659
                 6679*******99.555555445555543 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.5
                 CTHHHHHHHHHHHHH CS
         RGS  24 seenlsFwlaveefk 38 
                 ++ n+sF+l++ ++ 
  EFC38714.1 911 NSTNISFYLNTITYC 925
                 678999999876665 PP

  == domain 3  score: 38.6 bits;  conditional E-value: 1.9e-13
                  HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.....SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.....STTTT CS
         RGS    2 leslledqpgrslFreFlesefseenlsFwlaveefkka.....keqeelkkkakeIyneylapsspkelnidkklreelekrleke.....qpsrk 88  
                  l+++l+d    slF++F  +efs+enl  +   +e++ +     k+ e+ +k+ +eI+++yl + s+ e+ni++++r++l + ++ +     ++ +k
  EFC38714.1 1183 LQEILNDGLAYSLFEKFTVKEFSKENLLCYNSLQELEDEkqfyqKDLENQVKMLEEIIEKYLTQTSSFEVNIPSNTRKNLINLIKSKegltkENVKK 1279
                  799***********************************999998888889999*******************************9999***9***** PP

                  TTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS   89 lfeeaqeevfellekdsypkFlkselyl 116 
                   +e +++ ++  l +d +++F +s+ y+
  EFC38714.1 1280 SLESLKSDILVNL-TDTFSRFTTSQSYE 1306
                  ************9.699********996 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.6   4.8   1.1e-09   6.3e-06       2      43 ..     780     821 ..     779     823 .. 0.76

  Alignments for each domain:
  == domain 1  score: 26.6 bits;  conditional E-value: 1.1e-09
         GPS   2 sCvfWdeeneetgsWsteGCel....tesdnknetv.CsCnHLtsFA 43 
                  C +W   ne+ ++W ++GC+     t    + ++v CsC+H+t FA
  EFC38714.1 780 VCKYW---NETVSDWLSNGCTRtallTY--GDYYVVeCSCDHTTQFA 821
                 6****...6788********55454333..4555555*********9 PP

>> Bac_DNA_binding  Bacterial DNA-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.2     0.033     2e+02       8      43 ..    1216    1251 ..    1215    1255 .. 0.88
   2 ?    7.2   0.2   0.00096       5.7       2      36 ..    1258    1292 ..    1257    1318 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.033
                       HHHHTT----HHHHHHHHHHHHHHHHHHHHTT-EEE CS
  Bac_DNA_binding    8 eeiaektgltkkdakrvveafldtikeaLkkgekve 43  
                       +e+ ++ ++ +kd ++ v++++++i++ L +  ++e
       EFC38714.1 1216 QELEDEKQFYQKDLENQVKMLEEIIEKYLTQTSSFE 1251
                       688889999********************9988766 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.00096
                       EHHHHHHHHHTT----HHHHHHHHHHHHHHHHHHH CS
  Bac_DNA_binding    2 tkkeLieeiaektgltkkdakrvveafldtikeaL 36  
                       t+k Li+ i  k gltk+++k+ +e++ + i  +L
       EFC38714.1 1258 TRKNLINLIKSKEGLTKENVKKSLESLKSDILVNL 1292
                       89***********************9988776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1325 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1577  (0.0879581); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.95u 0.32s 00:00:01.27 Elapsed: 00:00:00.49
# Mc/sec: 8052.90
//
Query:       EFC38715.1  [L=674]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-08   33.7   0.1      0.004   16.6   0.0    2.3  2  Fringe    Fringe-like
     0.0088   15.6   0.1      0.016   14.7   0.1    1.3  1  CAP_N     Adenylate cyclase associated (CAP) N terminal


Domain annotation for each model (and alignments):
>> Fringe  Fringe-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   4.5e-07     0.004      35     163 ..     109     235 ..     106     282 .. 0.66
   2 !   14.7   0.0   1.7e-06     0.015      72     128 ..     480     537 ..     451     547 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 4.5e-07
      Fringe  35 keqtfiftdvedeelrke..........agknvvvtncsashsrkalsikmsae.ydafleskkkWfchvDDDnylnveaLlklLskynhtqdvylGkp 122
                 ke+tf+ftd+e++  + +          +g +v    +++       si +  e + +  +++ +Wf++ DDD +  + +L++ L+ky+ + +   G+ 
  EFC38715.1 109 KENTFFFTDIEPSPSHVSffsritlmasKGGKVGYDGAQRRFL---ESIFTMLElKKERNDKRVRWFMLSDDDHMSIPANLMRTLAKYELKLE--RGEL 202
                 6778888888876655554443433222233333333332222...233333330334455666************************98765..69** PP

      Fringe 123 sldrpieaterteenkkkkvkfwfatGGaGfclsralalkl 163
                 s+d+p+ +         ++ +  ++ GGaG++++ + ++ l
  EFC38715.1 203 SVDEPLIIG--------RTPECRAVSGGAGVIFNEKAIEVL 235
                 ****99993........345667899999999998888777 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.7e-06
      Fringe  72 sikmsaeydafleskkkWfchvDDDnylnveaLlklLskynhtqdvylG.kpsldrpi 128
                 +i   ae  +  ++++kW ++v   + +n ++Ll+ L++++++ ++y+G  +s +++i
  EFC38715.1 480 KISLYAECLKKSSTSSKWTLVVSESTRINSDSLLQYLKTFSNSAKLYIGgMRSAQELI 537
                 3333344444556667********************************8245666555 PP

>> CAP_N  Adenylate cyclase associated (CAP) N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.1   1.8e-06     0.016     217     258 ..      24      69 ..      21      90 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.8e-06
                 TS----TTSBE...........SSC--XXXXXXX....XXXXXXXX CS
       CAP_N 217 tGltWnkkGkdaeealk....aaaaaasaaaaggpppPpPpPppas 258
                  Gl  ++kG d++e ++    a  +  s++++++p+pPpPpPpp+ 
  EFC38715.1  24 FGLFSKRKGNDISESITtgrvALDKIDSKSSTSKPAPPPPPPPPTY 69 
                 5777789999999999988763344444555555666666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (674 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       813  (0.0453455); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.74u 0.32s 00:00:01.06 Elapsed: 00:00:00.49
# Mc/sec: 4097.75
//
Query:       EFC38716.1  [L=249]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (249 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3619  (0.201852); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.50
# Mc/sec: 1510.46
//
Query:       EFC38717.1  [L=114]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.41   10.6   5.2         16    5.5   3.9    2.3  2  HU-CCDC81_bac_2  CCDC81-like prokaryotic HU domain 2


Domain annotation for each model (and alignments):
>> HU-CCDC81_bac_2  CCDC81-like prokaryotic HU domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0    0.0019        34      28      46 ..      32      50 ..      14      63 .. 0.85
   2 ?    5.5   3.9   0.00086        16       7      40 ..      68     101 ..      66     113 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.0019
  HU-CCDC81_bac_2 28 elkqeLeeegrveleniGe 46
                     + ++++++e  ve+++iG+
       EFC38717.1 32 NNNSKIKKERIVEIPSIGT 50
                     668999************8 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.00086
  HU-CCDC81_bac_2   7 iaeaegisyeeAlqkiekeveelkqeLeeegrve 40 
                      iae e+   ee + ki+k++ee k++L++ ++++
       EFC38717.1  68 IAENEKRKAEEEVLKIKKQIEEEKSKLKQVQQIK 101
                      8999999999999999999999999999998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3508  (0.195661); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.28s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 768.10
//
Query:       EFC38718.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0021   18.0   0.4     0.0073   16.2   0.0    1.8  2  DUF3137   Protein of unknown function (DUF3137)
  ------ inclusion threshold ------
          1    9.4   6.2          2    8.5   1.5    2.3  2  CCD       WisP family C-Terminal Region


Domain annotation for each model (and alignments):
>> DUF3137  Protein of unknown function (DUF3137)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.1      0.11   9.8e+02      28      79 ..      69     123 ..      39     155 .. 0.66
   2 !   16.2   0.0   8.2e-07    0.0073      55     109 ..     156     213 ..     153     232 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.11
     DUF3137  28 keskkkkekklekvkledpeFekkFeVysnd...qvearyiLtpalmerllelre 79 
                 ++ + k ++++e+++le  +   k ++  ++   q++   iL+++l  + ++l  
  EFC38718.1  69 NNVNTKVNSSEERLRLEAKNLITKWTTREQQdnlQIKDNLILNTSLNMSSNNLSS 123
                 4555666667777777777777777777443344777777777776655555544 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 8.2e-07
     DUF3137  55 ysndqvearyiLtpalmerllelrekfkg...kikasfkdnklyiaietrknlFepsl 109
                  s+dqv a ++L++ lm+++++ r +      k+++s++ +k +++++  +  Fe+++
  EFC38718.1 156 LSDDQVSANQLLNTPLMDKIKDKRPSELTrweKLRLSMERKKNVVVLNVLEPTFESKI 213
                 69********************96433333689**************99999999444 PP

>> CCD  WisP family C-Terminal Region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   1.5   0.00022         2      58      89 ..      16      47 ..       8      80 .. 0.78
   2 ?    3.3   0.2    0.0089        80      63      97 ..     114     149 ..     106     169 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00022
         CCD 58 apssttnatgntsgktrvkrdtpttppehplk 89
                 p+ ++ +t nt+  + ++ +  ttp +hpl 
  EFC38718.1 16 IPAQSSTTTNNTTTSSNMRGNRSTTPQQHPLL 47
                455555566677777777777789******85 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.0089
         CCD  63 tnatgntsgktrvkrdtpttppehpl.ksvndqitk 97 
                  n + n    + +kr t +   e pl ks n   tk
  EFC38718.1 114 LNMSSNNLSSSSIKRTTSSIRNENPLlKSTNPITTK 149
                 567777788899************964788877666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1104  (0.0615762); expected 358.6 (0.02)
Passed bias filter:                      228  (0.0127168); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.51
# Mc/sec: 1405.18
//
Query:       EFC38719.1  [L=411]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0014   18.8   1.4     0.0044   17.2   1.4    1.9  1  USP8_dimer  USP8 dimerisation domain
  ------ inclusion threshold ------
      0.025   14.4   3.1       0.02   14.8   1.8    1.4  2  DUF445      Protein of unknown function (DUF445)
       0.03   15.3   2.0       0.03   15.3   2.0    4.8  4  AIM3        Altered inheritance of mitochondria protein 3


Domain annotation for each model (and alignments):
>> USP8_dimer  USP8 dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   1.4   7.4e-07    0.0044      21      79 ..      14      74 ..       7     109 .. 0.70

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 7.4e-07
  USP8_dimer 21 klkkdkknksikrllrsaeklfkkAeeyrlegdeEkAYvlymkylnll.elIr.kksdyke 79
                k+   + n+s++ +++ + + +k+A +y++ +d E+ Y+++  y  l+   ++ ++  +++
  EFC38719.1 14 KIGLIDSNRSLSEYFKDGANYLKQAGQYKRINDYENCYIYLQAYELLVcHRLPsEHAQFND 74
                55677899********************************999987776554414555544 PP

>> DUF445  Protein of unknown function (DUF445)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       1.2   7.2e+03      86     103 ..      92     109 ..      77     145 .. 0.66
   2 ?   14.8   1.8   3.3e-06      0.02     148     265 ..     251     362 ..     231     401 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 1.2
      DUF445  86 aaiveellkeiledldde 103
                 +++++++l+ei +++ +e
  EFC38719.1  92 QEEKRQILEEIFKKYPEE 109
                 444444555554444443 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 3.3e-06
      DUF445 148 driknllkdeevkekikelidelieeesgklvlesivsmflreltsilekvksdpdhllreeedkkvreliadllndpelaakveklkkkklsdlevqe 246
                   + +++++++v+ek+ + + +++++e+   v e+++s + ++  s  ++ ++ + + ++++ d+k   l++ +++++++++ v +   k++ + e q+
  EFC38719.1 251 SGVGKVVHNDQVQEKVGQGVANFANNEK---VQERVGSAVSNA--SNNREYQKSVGNMISKNTDNK---LVSGFAQNEQVQQTVGTAISKTVGNKEFQQ 341
                 5677788889999999999999988883...356666666666..455677778888889999988...999999999999999999999999999888 PP

      DUF445 247 yeea..lwealkdlllkdlne 265
                 ++ +    +a ++ ++k++++
  EFC38719.1 342 KAGTaiANAATNKEVQKKVAS 362
                 888874445555566666655 PP

>> AIM3  Altered inheritance of mitochondria protein 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   4.0      0.69   4.1e+03      59      79 ..     106     133 ..      76     145 .. 0.67
   2 ?   -1.2   7.6       0.7   4.2e+03      58      84 ..     143     170 ..     135     174 .. 0.65
   3 ?   -1.3   3.9      0.72   4.3e+03      23      60 ..     172     221 ..     168     314 .. 0.73
   4 ?   15.3   2.0   4.9e-06      0.03       3      49 ..     359     405 ..     357     411 .] 0.89

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.69
        AIM3  59 dydtstsleslrdprsFppP.......P 79 
                   ++++s++++ +  ++ppP       P
  EFC38719.1 106 YPEERSSVNNVVNSGQLPPPsfkkvppP 133
                 345888999999999***9955555542 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.7
        AIM3  58 edydtstsleslrdp.rsFppPPlkpgq 84 
                 + +++st+++  + p +s+ppPP++ + 
  EFC38719.1 143 QTQKSSTPPPFIPKPqSSLPPPPVNNNV 170
                 4444555555556652689*****9875 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.72
        AIM3  23 aKsGyqagKkhykkskekreerdgk..................ddsdeereededy 60 
                   + y+ + + + +++ ++++r+g+                  +      ++ +++
  EFC38719.1 172 NNYNYNNSNTVVSQQQPQQQSRSGSilssfsnlslggsssnsgN------NSHSSS 221
                 56678888888888888888888887766666666553322221......111111 PP

  == domain 4  score: 15.3 bits;  conditional E-value: 4.9e-06
        AIM3   3 siksGlktagKygykGtksvaKsGyqagKkhykkskekreerdgkdd 49 
                 +++sG+ t +K ++kG k+ +  + q gK   +++k++++ +d++dd
  EFC38719.1 359 KVASGFMTLAKGAVKGGKAASSLAVQGGKAYLENQKNQQNDHDSDDD 405
                 789************************************99977654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (411 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1618  (0.0902449); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 2471.60
//
Query:       EFC38720.1  [L=195]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.015   15.9   4.9      0.015   15.9   4.9    2.8  2  FlgN             FlgN protein
      0.049   13.9   0.3        0.1   12.8   0.3    1.5  1  DUF4279          Domain of unknown function (DUF4279)
       0.21   12.0   1.8        1.1    9.8   0.2    2.5  2  Mvb12            ESCRT-I subunit Mvb12
       0.45    9.8   6.7       0.43    9.9   5.6    1.6  2  DUF4407          Domain of unknown function (DUF4407)
        1.1    9.4   6.5        3.8    7.6   1.9    2.0  2  Cob_adeno_trans  Cobalamin adenosyltransferase
        1.9    8.6   7.5          2    8.6   0.1    3.2  4  RapH_N           response regulator aspartate phosphatase H, 
        2.3    7.1  17.7      0.082   11.9  11.1    1.7  2  IFT57            Intra-flagellar transport protein 57
        6.6    6.2  13.5         14    5.1  13.5    1.6  1  Exonuc_VII_L     Exonuclease VII, large subunit


Domain annotation for each model (and alignments):
>> FlgN  FlgN protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.9   4.9   6.5e-06     0.015      48     134 ..       2      95 ..       1     101 [. 0.79
   2 ?    2.2   3.0       0.1   2.3e+02      45     107 ..      93     154 ..      87     191 .. 0.59

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 6.5e-06
                 HHHHHHHHHHHHHHHHHHHHTT--....SCHHHHHHHHCT...TCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHXXXX CS
        FlgN  48 qellekleqleqkrakllaelgls....aeeatlsellak...eedeelkelwqelkelleelkelnelNgrlieqslefnqrllnllqgaank 134
                 ++ll++ +qle+k+++ l   ++     ++e+  ++++++   ++++  +++ +e+++ll+el+e+n++ +++i++  ++   + +++ +  ++
  EFC38720.1   2 NQLLKQATQLENKIEQKLITYQNLatkiEDELFQEPIVSNnisTSEQLFEAITEEIDHLLKELREVNDRMKEFIKDENNHSILSSSIVYQYEQH 95 
                 689**************99999997776666666666666**6666666777778*******************99888776666666666665 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.1
                 HHHHHHHHHHHHHHHHHHHHHHHTT--.............SCHHHHHHHHCTTCCHHHHHHHHHHHHHHHHHHHHH CS
        FlgN  45 eekqellekleqleqkrakllaelgls.............aeeatlsellakeedeelkelwqelkelleelkeln 107
                 e+ ++  ++++q+ + r++ la+ +++              e+++l    +++e +              +l+++n
  EFC38720.1  93 EQHETFFNRIKQEFKSRRQRLANKKNRndllyisdeedvnNENDSLLGSSRESEIQ--------------RLRDTN 154
                 67788889999999999999999999844444433333222222222222213333..............333333 PP

>> DUF4279  Domain of unknown function (DUF4279)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.3   4.5e-05       0.1      50      98 ..      51     101 ..      35     116 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 4.5e-05
     DUF4279  50 ldleeqldklldrlepkaekikelakkygleiylqvviyiedgeqpel..h 98 
                 + + e +d+ll++l    ++ ke+ k+ + +  l++ i ++++++++   +
  EFC38720.1  51 EAITEEIDHLLKELREVNDRMKEFIKDENNHSILSSSIVYQYEQHETFfnR 101
                 678899************************99****9*9999986533333 PP

>> Mvb12  ESCRT-I subunit Mvb12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.2   0.00048       1.1      27      63 ..      38      74 ..       7      86 .. 0.83
   2 ?    1.1   0.0      0.25   5.6e+02      24      65 ..     142     183 ..     118     189 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00048
                ------HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHH CS
       Mvb12 27 lkleelqptkemlepwykecdelvealekhdksgeeF 63
                +  +++ ++++++e+  +e d+l ++l++ +++ +eF
  EFC38720.1 38 IVSNNISTSEQLFEAITEEIDHLLKELREVNDRMKEF 74
                55677788899**********************9999 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.25
                 ---------HHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHH CS
       Mvb12  24 vpelkleelqptkemlepwykecdelvealekhdksgeeFdk 65 
                   e ++++l++t+  ++  +++    ++ale++ +  ++Fd+
  EFC38720.1 142 SRESEIQRLRDTNIRMQNLITQGHTSKAALEEQMEIFRNFDR 183
                 456678888888888888888888888888888888888886 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   5.6   0.00019      0.43     135     227 ..       1     121 [.       1     162 [. 0.77
   2 ?   -1.2   1.6      0.47   1.1e+03     130     160 ..     131     172 ..     102     180 .. 0.55

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00019
     DUF4407 135 laeleaqiaalqaeidaaearldalraeaqkeldgtk..gtgttgvaGkgpaakekkaqldaaqaelaelkakld........................ 207
                 +++l +q ++l+++i+++  ++++l ++ ++el++++  ++    +   ++ +++ ++++d + +el e++++++                        
  EFC38720.1   1 MNQLLKQATQLENKIEQKLITYQNLATKIEDELFQEPivSNN---ISTSEQLFEAITEEIDHLLKELREVNDRMKefikdennhsilsssivyqyeqhe 96 
                 57899*******************************987655...5568999999999***********9999999999*******9999777777766 PP

     DUF4407 208 .....atarlaalraelaeleaera 227
                       +++++++r++la  +++ +
  EFC38720.1  97 tffnrIKQEFKSRRQRLANKKNRND 121
                 6666644555555555444433333 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.47
     DUF4407 130 a...........ltaelaeleaqiaalqaeidaaearldalr 160
                              ++e+++l++ + ++q+ i++ ++  +al+
  EFC38720.1 131 VnnendsllgssRESEIQRLRDTNIRMQNLITQGHTSKAALE 172
                 133334444444666777777777777766666665555555 PP

>> Cob_adeno_trans  Cobalamin adenosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   1.9    0.0017       3.8      46     112 ..       8      78 ..       1      89 [. 0.64
   2 ?    5.0   0.3     0.011        24      49     128 ..      91     179 ..      77     192 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0017
                      CTTTTHHHHHHHHHHHHHHHHHHHHHHT.....-BTCCG-S--HHHHHHHHHHHHHHHHHS--EESEEES- CS
  Cob_adeno_trans  46 laeeeeelkeaLeeiqneLfdlgaelatp....ekkkekkkiteeeveelekeideleaelpplksfilpg 112
                      +++ e++++++L   qn   ++  el  +    ++ ++++++ e+ +ee+++ ++el++  +++k+fi  +
       EFC38720.1   8 ATQLENKIEQKLITYQNLATKIEDELFQEpivsNNISTSEQLFEAITEEIDHLLKELREVNDRMKEFIKDE 78 
                      34457899999999***********9766565433333334444434445555555555555688888665 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.011
                      TTHHHHHHHHHHHHHHHHHHHHHHT.-BTCCG-S--.HHHH.........HHHHHHHHHHHHHS--EESEEES-SSHHHHHHHHHHHHHH CS
  Cob_adeno_trans  49 eeeelkeaLeeiqneLfdlgaelatpekkkekkkit.eeev.........eelekeideleaelpplksfilpggspaaaalhvaRtvcR 128
                      + e+ ++ +++i++e  +  + la+++++++   i+ ee+v         +  e+ei++l+++  ++++ i +g   + aal+    + R
       EFC38720.1  91 QYEQHETFFNRIKQEFKSRRQRLANKKNRNDLLYISdEEDVnnendsllgSSRESEIQRLRDTNIRMQNLITQGH-TSKAALEEQMEIFR 179
                      356788899999999999999999997777777777566666666666777899999999988888888888775.45555555555555 PP

>> RapH_N  response regulator aspartate phosphatase H, N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.4     0.027        60      21      37 ..       3      19 ..       1      24 [. 0.85
   2 ?    8.6   0.1   0.00088         2       4      40 ..      22      60 ..      19      67 .. 0.79
   3 ?   -2.8   0.0       3.1   6.9e+03      22      38 ..      91     107 ..      89     108 .. 0.75
   4 ?   -2.4   0.0       2.4   5.4e+03      20      39 ..     163     183 ..     158     189 .. 0.47

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.027
                T-HHHHHHHHHHHHHHH CS
      RapH_N 21 rsvekAeelkeeikqel 37
                + +++A++l ++i+q+l
  EFC38720.1  3 QLLKQATQLENKIEQKL 19
                5679***********98 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00088
                HHHHHHHHHH..HHHHHHTT-HHHHHHHHHHHHHHHCTS CS
      RapH_N  4 seeVgnklne..WYsaIkkrsvekAeelkeeikqeleem 40
                +++ ++k+++  + + I +++++ +e+l e i +e++++
  EFC38720.1 22 YQNLATKIEDelFQEPIVSNNISTSEQLFEAITEEIDHL 60
                56666666554466779*******************986 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 3.1
                 -HHHHHHHHHHHHHHHC CS
      RapH_N  22 svekAeelkeeikqele 38 
                 ++e+ e   + ikqe++
  EFC38720.1  91 QYEQHETFFNRIKQEFK 107
                 56777788888888876 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 2.4
                 TT-HHHHH.HHHHHHHHHHCT CS
      RapH_N  20 krsvekAe.elkeeikqelee 39 
                 + +++kA+ e + ei +++++
  EFC38720.1 163 QGHTSKAAlEEQMEIFRNFDR 183
                 445554431233455555554 PP

>> IFT57  Intra-flagellar transport protein 57
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9  11.1   3.6e-05     0.082     226     332 ..       5     117 ..       2     123 .. 0.90
   2 ?   -1.0   0.5       0.3   6.7e+02     268     318 ..     139     189 ..     124     192 .. 0.62

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3.6e-05
       IFT57 226 leqmkkhkksieeslpetksqlkklhedisk...tlekiesrEky...lnsqleellqeyreaqeelsevkekykqlsegvseltrelaeiseelekvk 318
                 l+q  +++++ie++l ++++  +k+++++ +   + ++i++ E+    +++++++ll+e+re++++++e+ ++ ++ s   s+   ++++ ++ ++++k
  EFC38720.1   5 LKQATQLENKIEQKLITYQNLATKIEDELFQepiVSNNISTSEQLfeaITEEIDHLLKELREVNDRMKEFIKDENNHSILSSSIVYQYEQHETFFNRIK 103
                 78999***********************9773334799*****96333799************************************************ PP

       IFT57 319 qemeergssmtDgs 332
                 qe ++r +++++ +
  EFC38720.1 104 QEFKSRRQRLANKK 117
                 ********999876 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.3
       IFT57 268 lnsqleellqeyreaqeelsevkekykqlsegvseltrelaeiseelekvk 318
                 l s+ e+++q +r+++ +++++  + ++ ++ ++e+ + +++ +  l+++k
  EFC38720.1 139 LGSSRESEIQRLRDTNIRMQNLITQGHTSKAALEEQMEIFRNFDRVLNNMK 189
                 455556666777777777666666666666666666665555555555555 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1  13.5    0.0063        14     135     259 ..      50     188 ..       1     194 [. 0.56

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0063
  Exonuc_VII_L 135 Aelvvpdkaeleeqleelerrlekaikrlleekkqrleklasrlkspeellerkrqrldeleerleralkkq...lkkkrerleelkerl.keklee 227
                    e++++++++l+++l+e+++r+++ ik   +++    +++  ++++ e+ ++r +q++++ ++rl ++ +++   + + +e++++ +++l  ++ e+
    EFC38720.1  50 FEAITEEIDHLLKELREVNDRMKEFIKDENNHS-ILSSSIVYQYEQHETFFNRIKQEFKSRRQRLANKKNRNdllYISDEEDVNNENDSLlGSSRES 145
                   567788888888888888888888887654322.222333444455555666666666666666666544445553333444444444443322233 PP

  Exonuc_VII_L 228 kkerlkklkerle...........lleekkerleeleekleal 259
                   + +rl++++ r++            lee+ e +++  + l+++
    EFC38720.1 146 EIQRLRDTNIRMQnlitqghtskaALEEQMEIFRNFDRVLNNM 188
                   3333333322333322222233334555555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (195 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2399  (0.133806); expected 358.6 (0.02)
Passed bias filter:                      579  (0.032294); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 1262.85
//
Query:       EFC38721.1  [L=539]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.9e-86  287.5   0.0    1.1e-85  287.1   0.0    1.2  1  Malic_M       Malic enzyme, NAD binding domain
    2.2e-46  157.9   0.3    4.6e-46  156.9   0.1    1.6  2  malic         Malic enzyme, N-terminal domain
  ------ inclusion threshold ------
       0.17   12.0   0.5        0.6   10.2   0.1    2.1  2  Shikimate_DH  Shikimate / quinate 5-dehydrogenase


Domain annotation for each model (and alignments):
>> Malic_M  Malic enzyme, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  287.1   0.0   1.8e-89   1.1e-85       1     258 []     227     497 ..     227     497 .. 0.97

  Alignments for each domain:
  == domain 1  score: 287.1 bits;  conditional E-value: 1.8e-89
                 THHHHHHHHHHHHHHHHHH-S-...GGG--EEEEC-SHHHHHHHHHHHHHHHTTTS-HHHHHTTEEEEETTEE-BTT-.S---TTTGGGSBS--SS--S CS
     Malic_M   1 iqgTaavalagllaalkitgkk...lseqkivvlGaGsagiGiaeqivealvkeGlseeeakkkiylvDrkGLltedr.ekleeekkpfakkkeelkea 95 
                 iqgT++v ++g+l++l++ g+k   +++qki+++G+Gsag+G+++ + ea+v+eGl +eea+k++y+vD++GLlt++r e+ +e+  +f+++++ ++e+
  EFC38721.1 227 IQGTGSVIVSGILNSLRAIGQKfedIKDQKIMIVGSGSAGLGVTNSLKEAMVREGLDDEEARKNFYIVDKDGLLTSRRiEEGDEKGIHFTSSQRYYAEV 325
                 9*******************9966679**************************************************9788899999999999999888 PP

                 ........SHHHHHHHH--SEEEE-SSSSS-S-HHHHHHHHHHSS....S-EEEE--SSGGGSSS-HHHHHHHTTT-SEEEESS----EEE.TSEEE-- CS
     Malic_M  96 k....dkltLeevvkkvkptvliGlsgvagafteeivremakste....rPiilplSNPtskaEataedvlkwtdgkalvasGsPfkpvel.ngktyei 185
                 +    + l+++e +++vkp++l+Glsg++g+fte+i++em+++++    +Pii+plSNPtsk+Ea ae v+k+t+gk ++asGsPf+ v+l ng+ +++
  EFC38721.1 326 RddlpEGLSILETIRTVKPDILLGLSGIGGLFTEDILKEMSNQCKqrgkEPIIFPLSNPTSKSEASAELVFKCTEGKGVFASGSPFDLVTLpNGQVIRP 424
                 8888899***********************************99988889************************************************* PP

                 EE--GGGTHHHHHHHHHHTT-SS--HHHHHHHHHHHHTT--HHHHHTT-SS--GGGHHHHHHHHHHHHHHHHH CS
     Malic_M 186 gQaNNayifPglglgvivarakritdemllaaaealaelvseeelkegsllPelseirevslkvavavakaav 258
                  QaNN++ifP+lgl   ++++++itd+ml+aa++ala +vs+e + +++++P++++irevs+kva+ v+++a+
  EFC38721.1 425 PQANNMFIFPALGLMSQISGCNTITDNMLYAASKALAATVSDEAILRKEVYPKVEDIREVSKKVAIGVIRQAY 497
                 **********************************************************************996 PP

>> malic  Malic enzyme, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  156.9   0.1   7.7e-50   4.6e-46      55     182 .]      91     217 ..      79     217 .. 0.93
   2 ?   -3.0   0.0      0.92   5.5e+03      59      76 ..     249     264 ..     238     271 .. 0.50

  Alignments for each domain:
  == domain 1  score: 156.9 bits;  conditional E-value: 7.7e-50
                 HHHHHTTSS.SS..EEEEE-SSSBTTTBS-GHHHHHHHHHHHHHHHHHHS-EGGGEEEEEECS-BS.HHHHC.TT..S.SSB...SHHHHHHHHHHHHH CS
       malic  55 ikeilknlpeedvkvivvtdgeriLGlGdlGvagvgimvGKlaLytalagidPekvlpvvldvgtnneelledplYlGlrkkRvkgeeydefvdefvea 153
                 i+e  ++l+++  k+   tdg riLGlGdlG++g gi++GKlaLy+a++gi+P +vlpv+ldvgtnne+ll+dplYlG++kkR++g+ey ++vdef+ea
  EFC38721.1  91 ITERYNSLQTDIDKYQFLTDGGRILGLGDLGANGDGIPIGKLALYVAAGGINPGRVLPVMLDVGTNNEKLLNDPLYLGIKKKRLTGQEYFDVVDEFMEA 189
                 555555555555678899********************************************************************************* PP

                 HHHHHGCTSEEEE-S--CCHHHHHHHHHC CS
       malic 154 vkelfppkaliqfEDfkaknafeileryr 182
                 +++++ p++liqfEDf +++a  +l++yr
  EFC38721.1 190 ITTRW-PNVLIQFEDFTSDKAEVVLKKYR 217
                 *****.**********************8 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.92
                 HTTSS.SS..EEEEE-SS CS
       malic  59 lknlpeedvkvivvtdge 76 
                 +++++  d k+++v  g+
  EFC38721.1 249 FEDIK--DQKIMIVGSGS 264
                 22222..23445555555 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.1    0.0001       0.6       5      37 ..     247     279 ..     243     281 .. 0.89
   2 ?   -1.8   0.0      0.49   2.9e+03      79     104 ..     459     485 ..     449     492 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.0001
                   HHHS..TT-EEEEES-SHHHHHHHHHHHCCT-C CS
  Shikimate_DH   5 kkleslkekkvlliGaGemaelvakhLlakgvk 37 
                   +k+e++k++k++++G G  +  v++ L ++ v+
    EFC38721.1 247 QKFEDIKDQKIMIVGSGSAGLGVTNSLKEAMVR 279
                   799********************9999987765 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.49
                   EEE-SSSSS-SB-HHHHHCCHHH.S.. CS
  Shikimate_DH  79 visataseepilekeeveealkkrk.k 104
                    ++at s e+il+ke   ++ + r+ +
    EFC38721.1 459 ALAATVSDEAILRKEVYPKVEDIREvS 485
                   578999999999999887777766654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (539 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       625  (0.0348597); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.32s 00:00:01.05 Elapsed: 00:00:00.53
# Mc/sec: 3035.97
//
Query:       EFC38722.1  [L=554]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.029   13.5   1.5      0.094   11.8   1.5    1.8  1  NAD_synthase  NAD synthase


Domain annotation for each model (and alignments):
>> NAD_synthase  NAD synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   1.5   5.3e-06     0.094     167     231 ..     161     228 ..     139     233 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.3e-06
                   T--HHHHCS--B--SSTT-BHH...HHHSS-HHHHHHHHTHSSSS...HHHHHTTT--HHHHHHHHHH CS
  NAD_synthase 167 nvPervlkkpPsAdLkpgqtDe...eeLgikYdelDeiLklvekkkspeeiikekelpaevvekiekl 231
                    vP  v +k+ + +   + +D+    +++ +Y +lD++  + + +  +eei ++ e+++++v+ i + 
    EFC38722.1 161 SVPSTVEEKQVTESFESNESDQlenVNFEKQYRTLDDYDDYSDDEAAQEEINDSEEIEQSQVNSINNN 228
                   4899999*****999777777522267899*********************************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (554 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1886  (0.105193); expected 358.6 (0.02)
Passed bias filter:                      252  (0.0140554); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 3244.34
//
Query:       EFC38723.1  [L=635]
Description: rho GTPase activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-22   79.7   1.9    4.1e-07   29.9   0.0    7.5  7  Kelch_4   Galactose oxidase, central domain
    1.1e-18   67.5   1.0      2e-18   66.7   1.0    1.4  1  RhoGAP    RhoGAP domain
    1.3e-18   66.8   4.8     0.0053   17.0   0.4    7.4  7  Kelch_3   Galactose oxidase, central domain
    5.4e-12   45.1   4.8    6.1e-07   28.9   0.0    5.6  6  Kelch_1   Kelch motif
    7.4e-11   41.9  15.5     0.0021   18.3   1.7    7.5  6  Kelch_6   Kelch motif
    1.7e-10   40.7  10.6      0.016   15.2   0.1    6.4  7  Kelch_5   Kelch motif
    4.4e-06   26.5   8.4       0.18   11.9   0.1    5.8  6  Kelch_2   Kelch motif
  ------ inclusion threshold ------
      0.071   12.1   0.0       0.22   10.5   0.0    1.8  2  RAG2      Recombination activating protein 2


Domain annotation for each model (and alignments):
>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.038        84       5      22 ..      16      37 ..      15      57 .. 0.69
   2 !   13.3   0.0   2.8e-05     0.064       1      22 [.      79     100 ..      79     115 .. 0.92
   3 ?    2.4   0.0     0.073   1.6e+02      30      46 ..     131     150 ..     117     154 .. 0.81
   4 !   29.9   0.0   1.8e-10   4.1e-07       1      47 [.     158     226 ..     158     229 .. 0.96
   5 !   16.6   0.0   2.7e-06     0.006       1      43 [.     230     277 ..     230     286 .. 0.90
   6 ?    2.2   0.0      0.08   1.8e+02      12      36 ..     302     335 ..     298     337 .. 0.80
   7 ?    2.4   0.0     0.072   1.6e+02      12      31 ..     361     380 ..     352     387 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.038
     Kelch_4  5 hsatsi....pdgtiylfGGrg 22
                ++a+ i    + +++y++GG +
  EFC38723.1 16 FAAVHIkghkDPNRFYVHGGKT 37
                5666665554559*******87 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 2.8e-05
     Kelch_4   1 pRaghsatsipdgtiylfGGrg 22 
                 pRa+h++ +i+ +++ l+GG+ 
  EFC38723.1  79 PRAHHTVNQIYENRLLLYGGQI 100
                 9*******************96 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.073
     Kelch_4  30 dlyll..dlstntWrrl.gs 46 
                 d y++  dls+nt +r+ ++
  EFC38723.1 131 DPYIYdiDLSQNTIQRIrTP 150
                 889984466*****999544 PP

  == domain 4  score: 29.9 bits;  conditional E-value: 1.8e-10
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedg.......................tllndlylldlstntWrrlgsl 47 
                 pR++hsa+s  +g++y++GG+g +                        ++lnd + +d++ n W++l+s+
  EFC38723.1 158 PRRYHSACSF-KGNLYVYGGEGFNYsinqqpkglgyylslqnlkraipEPLNDFWMFDTKLNVWKQLKSP 226
                 9*********.8************99*****************************************655 PP

  == domain 5  score: 16.6 bits;  conditional E-value: 2.7e-06
     Kelch_4   1 pRaghsatsipd.gtiylfGGrgedg....tllndlylldlstntWrr 43 
                 +R gh+++ + +  ++y++GG+g+       +++++  +d++++ W+ 
  EFC38723.1 230 GRYGHMMVLCEKrEKFYVVGGCGTSErgedVPFKEILEYDIASGNWQI 277
                 599*******5537**********9899******************75 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.08
     Kelch_4  12 dgtiylfGGrgedg.........tllndlylldl 36 
                 d+ i+++GG+  d           +l+d+ ++++
  EFC38723.1 302 DDFIFIVGGELLDRprslltmrePILDDVLIYNI 335
                 6999*****9887778888888888888888887 PP

  == domain 7  score: 2.4 bits;  conditional E-value: 0.072
     Kelch_4  12 dgtiylfGGrgedgtllndl 31 
                 ++++++ GGr++   +++ +
  EFC38723.1 361 NNRLIVLGGRSGSSYAYSSM 380
                 699********998888776 PP

>> RhoGAP  RhoGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   66.7   1.0   8.7e-22     2e-18       3     146 ..     403     555 ..     402     560 .. 0.87

  Alignments for each domain:
  == domain 1  score: 66.7 bits;  conditional E-value: 8.7e-22
                 HHHHHHHHHHH.HTTTSTTTTTS-S-HHHHHHHH..HHHHHTGGGCT....TTTTSCHHHHHHHHHHHHHHSSSTTTTGGHHHHHHH..HHTSSSHHHH CS
      RhoGAP   3 ivekcvefiek.rgldtegiyRvsgskarvkelr..eafdkgkavds....dleeedvhavaslLKrfLrelpepLltkelyeelie..aaksedeeer 92 
                 +++ cv++++k  +l+   ++  + + + + +lr   +fd+g+  d+    +++++++++vasl+  fL++lpep+lt ++y ++i+   a + + ee+
  EFC38723.1 403 MIDICVSYLKKsAALEFPKLFSTNYDMQDTLMLRlmLNFDHGHIHDEqdllSDHDTSPYSVASLICYFLESLPEPILTSQYYRKMIDlcNATNLTFEEK 501
                 5788******9555*******998776665555511677777777779999999********************************84566668889** PP

                 HHHHHHHHTTS-HHHHHHHHHHHHHHHHHHHTHHHH---HHHHHHHHHHHHHT- CS
      RhoGAP  93 lealkellekLPkenrdtLryLlehLkrvaenskenkMtaknLaivfaPtLlrp 146
                 + alke +++LPk n ++L+ ++e+L+ v++    ++ ++k L+++f+  Ll++
  EFC38723.1 502 IVALKEFIKTLPKDNVHILYRVCEFLCMVSDAYTTTEQNIKDLSMIFSHLLLST 555
                 ************************************************999986 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   2.4e-05     0.054       2      49 .]      28      88 ..      28      88 .. 0.78
   2 ?   -0.8   0.1       0.9     2e+03       1      10 [.      90      99 ..      90     116 .. 0.76
   3 !   11.9   0.0   9.7e-05      0.22      15      49 .]     128     167 ..     117     167 .. 0.77
   4 !   17.0   0.4   2.4e-06    0.0053       1      46 [.     169     236 ..     168     239 .. 0.77
   5 !   14.3   0.0   1.7e-05     0.037       2      33 ..     243     280 ..     242     301 .. 0.69
   6 ?    1.2   0.0      0.21   4.7e+02       1      14 [.     302     315 ..     302     330 .. 0.86
   7 ?   -0.8   0.1      0.94   2.1e+03       1      15 [.     361     375 ..     361     386 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.4e-05
     Kelch_3  2 drlyifGGlgddg.qdrlndvyvydldtntWa....ei.........aslpp.aRaghaatai 49
                +r+y++GG++  + +++ n +++y +++  W+    ++         a+  + +Ra+h++ +i
  EFC38723.1 28 NRFYVHGGKT--RfNQFQNPLHLYYVEKLDWKfvklQLakeedpniiAEFEQrPRAHHTVNQI 88
                79********..889*********99999999887733555444445665556******9876 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.9
     Kelch_3  1 gdrlyifGGl 10
                ++rl+++GG 
  EFC38723.1 90 ENRLLLYGGQ 99
                589*****96 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 9.7e-05
     Kelch_3  15 qdrlndvyvydldtntWaeiasl.....ppaRaghaatai 49 
                 ++++   y +dl+ nt+++i ++     p +R++h+a+++
  EFC38723.1 128 TQYDPYIYDIDLSQNTIQRIRTPldlpiPKPRRYHSACSF 167
                 5666777889**********6653544477********75 PP

  == domain 4  score: 17.0 bits;  conditional E-value: 2.4e-06
     Kelch_3   1 gdrlyifGGlgd.....dgqdrl...................ndvyvydldtntWaei.aslppaRaghaa 46 
                 g+ ly++GG+g+     +  ++                    nd++++d+  n W+++ ++  p+R+gh +
  EFC38723.1 169 GN-LYVYGGEGFnysinQ--QPKglgyylslqnlkraipeplNDFWMFDTKLNVWKQLkSPARPGRYGHMM 236
                 45.999999999999551..3334455777777777788888****************6667889999955 PP

  == domain 5  score: 14.3 bits;  conditional E-value: 1.7e-05
     Kelch_3   2 drlyifGGlgd.dgqdrl..ndvyvydldtntWa...e 33 
                 +++y++GG+g+  +++ +  ++ ++yd+++++W+    
  EFC38723.1 243 EKFYVVGGCGTsERGEDVpfKEILEYDIASGNWQisgL 280
                 589*******8755544468*************95541 PP

  == domain 6  score: 1.2 bits;  conditional E-value: 0.21
     Kelch_3   1 gdrlyifGGlgddg 14 
                 +d+++i+GG+  d+
  EFC38723.1 302 DDFIFIVGGELLDR 315
                 589******99865 PP

  == domain 7  score: -0.8 bits;  conditional E-value: 0.94
     Kelch_3   1 gdrlyifGGlgddgq 15 
                 ++rl + GG+ +++ 
  EFC38723.1 361 NNRLIVLGGRSGSSY 375
                 699******996544 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0         1   2.3e+03      12      23 ..      28      45 ..      27      55 .. 0.67
   2 ?    2.2   0.0     0.059   1.3e+02      11      27 ..      90     106 ..      79     109 .. 0.82
   3 !   28.9   0.0   2.7e-10   6.1e-07       1      44 [.     158     225 ..     158     227 .. 0.98
   4 ?    4.6   0.0     0.011        25      12      39 ..     243     275 ..     236     277 .. 0.76
   5 ?   -3.4   0.0       3.5   7.9e+03      25      35 ..     326     336 ..     322     337 .. 0.83
   6 !    6.0   0.1     0.004       8.9       9      28 ..     359     380 ..     353     384 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1
                TEEEEEEEBCS......S CS
     Kelch_1 12 gkiYviGGsdg......g 23
                ++ Yv GG  +      +
  EFC38723.1 28 NRFYVHGGKTRfnqfqnP 45
                6789***98888666444 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.059
                 TTEEEEEEEBCSSSBEE CS
     Kelch_1  11 ggkiYviGGsdggnals 27 
                  +++   GG+ g+n++s
  EFC38723.1  90 ENRLLLYGGQIGYNPSS 106
                 69999********9998 PP

  == domain 3  score: 28.9 bits;  conditional E-value: 2.7e-10
                 BBBSEEEEEETTEEEEEEEBCS........................SSBEEEEEEEETTTTEEEEECC CS
     Kelch_1   1 aragagavvvggkiYviGGsdg........................gnalssvevyDpetntWrelps 44 
                 +r++++a+++ g +Yv GG  +                        +++l++++++D++ n W +l s
  EFC38723.1 158 PRRYHSACSFKGNLYVYGGEGFnysinqqpkglgyylslqnlkraiPEPLNDFWMFDTKLNVWKQLKS 225
                 79***************************************************************988 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.011
                 TEEEEEEEBCS.....SSBEEEEEEEETTTTEE CS
     Kelch_1  12 gkiYviGGsdg.....gnalssvevyDpetntW 39 
                 +k Yv+GG+         + + +  yD  ++ W
  EFC38723.1 243 EKFYVVGGCGTsergeDVPFKEILEYDIASGNW 275
                 688******987777777777777777776666 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 3.5
                 BEEEEEEEETT CS
     Kelch_1  25 alssvevyDpe 35 
                  l++v +y+ +
  EFC38723.1 326 ILDDVLIYNIR 336
                 699*****987 PP

  == domain 6  score: 6.0 bits;  conditional E-value: 0.004
                 EETTEEEEEEEBCS..SSBEEE CS
     Kelch_1   9 vvggkiYviGGsdg..gnalss 28 
                  +++++ v+GG++g  + ++s 
  EFC38723.1 359 IFNNRLIVLGGRSGssYAYSSM 380
                 689***********76555554 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.25   5.6e+02      11      42 ..      27      58 ..      17      60 .. 0.86
   2 ?    1.2   0.3      0.23   5.2e+02       4      23 ..      82     102 ..      79     157 .. 0.58
   3 !   18.3   1.7   9.2e-07    0.0021       1      46 [.     158     226 ..     158     231 .. 0.93
   4 ?    5.4   0.0     0.011        24       7      41 ..     236     276 ..     230     283 .. 0.84
   5 !    8.8   0.0   0.00088         2       6      37 ..     297     337 ..     296     347 .. 0.90
   6 !    7.7   0.2     0.002       4.4       6      34 ..     356     384 ..     353     389 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.25
     Kelch_6 11 ggkiYifGGytdsspylnkvwvydpetksWeq 42
                 +++Y+ GG t  ++++n +++y +e   W++
  EFC38723.1 27 PNRFYVHGGKTRFNQFQNPLHLYYVEKLDWKF 58
                4899*******999999999999888888876 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.23
     Kelch_6   4 ghslvs.vggkiYifGGytds 23 
                 +h++   + +++ ++GG+ ++
  EFC38723.1  82 HHTVNQiYENRLLLYGGQIGY 102
                 555544566777777776553 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 9.2e-07
     Kelch_6   1 praghslvsvggkiYifGGytds.......................spylnkvwvydpetksWeqlppl 46 
                 pr +hs++s  g +Y++GG +                          ++ln++w +d + ++W+ql ++
  EFC38723.1 158 PRRYHSACSFKGNLYVYGGEGFNysinqqpkglgyylslqnlkraiPEPLNDFWMFDTKLNVWKQLKSP 226
                 699*****************77789****************************************9665 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.011
     Kelch_6   7 lvsvg..gkiYifGGytds....spylnkvwvydpetksWe 41 
                 +v++   +k+Y++GG + s    + +++ ++ yd+ +++W+
  EFC38723.1 236 MVLCEkrEKFYVVGGCGTSergeDVPFKEILEYDIASGNWQ 276
                 566553379****99999999*******************7 PP

  == domain 5  score: 8.8 bits;  conditional E-value: 0.00088
     Kelch_6   6 slvsvggkiYifGGytds.........spylnkvwvydpet 37 
                 s+ + +++i+i+GG   +         +p l++v++y++++
  EFC38723.1 297 SADIFDDFIFIVGGELLDrprslltmrEPILDDVLIYNIRN 337
                 78899**********99999******************987 PP

  == domain 6  score: 7.7 bits;  conditional E-value: 0.002
     Kelch_6   6 slvsvggkiYifGGytdsspylnkvwvyd 34 
                 ++ + ++++ ++GG+++ss ++++++ ++
  EFC38723.1 356 QTLIFNNRLIVLGGRSGSSYAYSSMIYLN 384
                 67789************977777666665 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.16   3.6e+02       3      29 ..      11      41 ..       9      49 .. 0.63
   2 !    8.8   0.0   0.00071       1.6       4      29 ..      79     107 ..      78     115 .. 0.80
   3 !   15.2   0.1   7.1e-06     0.016       1      23 [.     155     177 ..     155     187 .. 0.91
   4 ?   -2.3   0.0       2.1   4.8e+03      30      39 ..     206     215 ..     205     216 .. 0.84
   5 !   14.9   0.0   9.1e-06      0.02       3      41 ..     229     272 ..     229     273 .. 0.93
   6 ?   -0.5   0.1      0.57   1.3e+03      30      40 ..     326     336 ..     296     338 .. 0.71
   7 ?    0.2   0.1      0.34   7.7e+02      10      30 ..     357     377 ..     350     384 .. 0.65

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.16
     Kelch_5  3 ppRaghcav.....tvsekiYvyGGkvgrdgs 29
                 p  g++av     ++++  Yv+GGk+ r ++
  EFC38723.1 11 FPSEGFAAVhikghKDPNRFYVHGGKT-RFNQ 41
                55566777733322334668******9.5555 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00071
     Kelch_5   4 pRaghcav.tvsekiYvyGGkvg..rdgs 29 
                 pRa+h +  ++++ +++yGG +g  +++ 
  EFC38723.1  79 PRAHHTVNqIYENRLLLYGGQIGynPSSV 107
                 8999999669************8664444 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 7.1e-06
     Kelch_5   1 iPppRaghcavtvsekiYvyGGk 23 
                 iP pR++h+a+  ++++YvyGG 
  EFC38723.1 155 IPKPRRYHSACSFKGNLYVYGGE 177
                 799*******************5 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 2.1
     Kelch_5  30 vsddvyvLdl 39 
                 + +d++ +d+
  EFC38723.1 206 PLNDFWMFDT 215
                 68*****997 PP

  == domain 5  score: 14.9 bits;  conditional E-value: 9.1e-06
     Kelch_5   3 ppRaghcavtvs..ekiYvyGGkvg...rdgsvsddvyvLdlps 41 
                 p+R+gh +v ++  ek Yv GG ++    ++ ++ +++ +d+ s
  EFC38723.1 229 PGRYGHMMVLCEkrEKFYVVGGCGTserGEDVPFKEILEYDIAS 272
                 68*********878**********99*999999********988 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 0.57
     Kelch_5  30 vsddvyvLdlp 40 
                 + ddv++++++
  EFC38723.1 326 ILDDVLIYNIR 336
                 46899999876 PP

  == domain 7  score: 0.2 bits;  conditional E-value: 0.34
     Kelch_5  10 avtvsekiYvyGGkvgrdgsv 30 
                 + + ++ ++v GG++g++  +
  EFC38723.1 357 TLIFNNRLIVLGGRSGSSYAY 377
                 455678899999999733333 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.49   1.1e+03       3      21 ..      81     106 ..      79     128 .. 0.61
   2 !   11.9   0.1     8e-05      0.18       1      25 [.     158     179 ..     158     189 .. 0.85
   3 ?    1.8   0.2      0.12   2.7e+02      30      47 ..     208     225 ..     205     227 .. 0.89
   4 !   10.9   0.0   0.00016      0.35       1      31 [.     230     259 ..     230     275 .. 0.85
   5 ?   -0.8   0.0      0.78   1.8e+03      14      27 ..     305     314 ..     297     328 .. 0.69
   6 ?   -0.2   0.0      0.51   1.1e+03      11      21 ..     361     375 ..     347     387 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.49
     Kelch_2   3 gghsss.vpggkiyvvGGa......h 21 
                 ++h++    +++++++GG        
  EFC38723.1  81 AHHTVNqIYENRLLLYGGQigynpsS 106
                 5555553458999****974434440 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 8e-05
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnp 25 
                 +r  hs+++  g +yv+GG    ++
  EFC38723.1 158 PRRYHSACSFKGNLYVYGGE---GF 179
                 6899***************8...44 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.12
     Kelch_2  30 sdvhvldlekhvWeevtp 47 
                 +d++ +d++ +vW+ ++ 
  EFC38723.1 208 NDFWMFDTKLNVWKQLKS 225
                 89************9876 PP

  == domain 4  score: 10.9 bits;  conditional E-value: 0.00016
     Kelch_2   1 rrgghsssvp..ggkiyvvGGahtdnpnlsssd 31 
                 +r+gh+++ +  + k yvvGG    ++++  +d
  EFC38723.1 230 GRYGHMMVLCekREKFYVVGGC---GTSERGED 259
                 69******999***********...55555555 PP

  == domain 5  score: -0.8 bits;  conditional E-value: 0.78
     Kelch_2  14 iyvvGGahtdnpnl 27 
                 i++vGG      ++
  EFC38723.1 305 IFIVGGE----LLD 314
                 9*****8....444 PP

  == domain 6  score: -0.2 bits;  conditional E-value: 0.51
     Kelch_2  11 ggkiyvvGGa....h 21 
                 +++++v GG+    +
  EFC38723.1 361 NNRLIVLGGRsgssY 375
                 899******944442 PP

>> RAG2  Recombination activating protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   9.6e-05      0.22      32     110 ..      21     100 ..       8     177 .. 0.80
   2 ?   -2.2   0.0       0.7   1.6e+03      78     104 ..     222     248 ..     219     254 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 9.6e-05
                 S-S.SS--EEEEEEEEETTTEEEEEEEEEEEEEE-SS-EEEEEEEE...--BSS---.S-BS-EEEEEEETTEEEEEEE--EE CS
        RAG2  32 asdesekeqylihGGktpnnelsdklyilslvskankkvtlrctek...elvgdvpe.aryGhtlsvvysrGksavvlfGGrs 110
                  + +++++++ +hGGkt  n++ + l++  ++    k v l+  +    +++++  + +r  ht++ +y    ++ +l+GG+ 
  EFC38723.1  21 IKGHKDPNRFYVHGGKTRFNQFQNPLHLYYVEKLDWKFVKLQLAKEedpNIIAEFEQrPRAHHTVNQIYE---NRLLLYGGQI 100
                 344558999***************99998888877776766654331125788876438999****9996...5778888874 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.7
                 --BSS---S-BS-EEEEEEETTEEEEE CS
        RAG2  78 elvgdvpearyGhtlsvvysrGksavv 104
                 +l++     ryGh + +   r k  vv
  EFC38723.1 222 QLKSPARPGRYGHMMVLCEKREKFYVV 248
                 5666666689***99988888876554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (635 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 3539.87
//
Query:       EFC38724.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.7e-50  168.9   4.8    7.1e-16   57.9   0.0    3.4  3  Mito_carr  Mitochondrial carrier protein
  ------ inclusion threshold ------
      0.069   13.0   0.2        9.5    6.0   0.0    2.6  3  DUF637     Possible hemagglutinin (DUF637)


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.2   0.7   2.3e-18   2.1e-14       4      95 ..      54     134 ..      52     136 .. 0.91
   2 !   57.8   0.0   8.8e-20   7.9e-16       7      96 ..     145     230 ..     140     231 .. 0.94
   3 !   57.9   0.0   7.9e-20   7.1e-16       4      94 ..     253     338 ..     250     341 .. 0.89

  Alignments for each domain:
  == domain 1  score: 53.2 bits;  conditional E-value: 2.3e-18
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCT CS
   Mito_carr   4 svlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllk 95 
                 ++++++ aG++ag+v++ v++P+d++Kt +q++++         i++ +k+i    G+r +y+Gl++ l +  p++a +f++ye +k++l+ 
  EFC38724.1  54 NPMQYMTAGAMAGLVEHAVMYPIDTIKTYVQSSNQG--------IFKSIKSI---GGIRNFYSGLTVVLYGALPSHAFYFTTYEAVKNILQG 134
                 578999*************************99988........66666666...7********************************9975 PP

  == domain 2  score: 57.8 bits;  conditional E-value: 8.8e-20
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCTT CS
   Mito_carr   7 kellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllkk 96 
                  + laG +a ++   ++tP+dv+K  +q++++ ++++    ++++ ++iy + Glr+++  l  ++l+++p+++  fv+ye++k+ l+++
  EFC38724.1 145 VSALAGIAATIAHDGIATPTDVIKQHMQLKGHVQNYN----LMSATREIYATRGLRAFFVSLPTTILMNIPYTSFHFVTYEYMKKKLFDH 230
                 5789*****************************9885....9*******************************************99876 PP

  == domain 3  score: 57.9 bits;  conditional E-value: 7.9e-20
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHH..HHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
   Mito_carr   4 svlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeG..lrglyrGllpnllrvapasalkfvlyetlkrlll 94 
                 + +k+++aGg+agav++lv +P+dvvKt lq+ +  + k       ++++ + keeG  l+ l+rG +p+++  +p++a+++++ye++k ++ 
  EFC38724.1 253 KHVKHFMAGGAAGAVGGLVSNPFDVVKTLLQVGQADTVK-------EAISLLRKEEGglLKNLFRGSIPRVVYFTPSAAVTWTTYEYIKYVFR 338
                 5689****************************9999766.......6888888988854489***************************9886 PP

>> DUF637  Possible hemagglutinin (DUF637)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0    0.0011       9.5      29      80 ..      43      94 ..      39     108 .. 0.82
   2 ?   -2.1   0.0      0.33     3e+03      45      59 ..     147     161 ..     125     179 .. 0.63
   3 ?    4.1   0.0    0.0042        38       6      41 ..     259     294 ..     255     319 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0011
      DUF637 29 kdlgssdalkslataavtAGllsgiddaslatsqdvaknavpqadastvsgv 80
                ++++ +d lk+  ++ +tAG+++g+ ++++    d+ k+ v++++++ ++++
  EFC38724.1 43 EEMEDNDELKGNPMQYMTAGAMAGLVEHAVMYPIDTIKTYVQSSNQGIFKSI 94
                67888999*****************988888777777777777777666655 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.33
      DUF637  45 vtAGllsgiddasla 59 
                 + AG+++ i+ + +a
  EFC38724.1 147 ALAGIAATIAHDGIA 161
                 234444444444444 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.0042
      DUF637   6 laslasqAavslinNkGdlsktlkdlgssdalksla 41 
                 +a+ a+ A+  l+ N  d+ ktl ++g+ d++k ++
  EFC38724.1 259 MAGGAAGAVGGLVSNPFDVVKTLLQVGQADTVKEAI 294
                 77889999999**********************876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 2035.50
//
Query:       EFC38725.1  [L=275]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
        4.6    5.7   4.4        6.6    5.1   4.4    1.1  1  MmgE_PrpD  MmgE/PrpD family


Domain annotation for each model (and alignments):
>> MmgE_PrpD  MmgE/PrpD family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   4.4   0.00037       6.6     340     420 ..      28     109 ..      21     115 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.00037
                 CCSCCCCTSCHHCCHHCCEEEEE-HHHHHHHTTT---EEEEETTS-B---EEESS-TTS.GGHHHHHHHHHHHHHHHHHCCS CS
   MmgE_PrpD 340 dfederladpevqaLrekvevvedpeltadypekrsivvvvlkdggrtleerveypkGh.prnplsreeleeKfrrlaegvl 420
                   e+++l+ p + ++++  e ++ ++ +a+  +++ ++++ lk+++++ +++ e +k    +++l++ e++eK ++++e+  
  EFC38725.1  28 PSEKSKLNAPFLEEFMKQFEEEKRKKTSANKSNTKDFLTMLLKQQEKISKKEEEEAKKLeKEKELTKIEILEKKQKNLEKLR 109
                 567888*************************999999**********9999888888777*****************99865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (275 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3288  (0.18339); expected 358.6 (0.02)
Passed bias filter:                      480  (0.0267723); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.36s 00:00:01.04 Elapsed: 00:00:00.56
# Mc/sec: 1481.78
//
Query:       EFC38726.1  [L=495]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-11   44.6   4.1     0.0047   17.2   0.0    6.0  6  Kelch_3   Galactose oxidase, central domain
    1.4e-05   25.2  12.4       0.77   10.1   0.1    5.7  6  Kelch_6   Kelch motif
    3.5e-05   23.7  11.4       0.49   10.4   0.1    5.7  6  Kelch_4   Galactose oxidase, central domain
  ------ inclusion threshold ------
      0.012   15.6   9.5        7.7    6.7   0.1    5.1  6  Kelch_2   Kelch motif
      0.052   13.6  14.8        2.4    8.3   0.1    5.4  6  Kelch_5   Kelch motif
       0.16   11.6   9.1        0.9    9.2   0.0    4.6  5  Kelch_1   Kelch motif


Domain annotation for each model (and alignments):
>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.14   4.3e+02       1      11 [.      62      72 ..      62      83 .. 0.87
   2 !   17.2   0.0   1.6e-06    0.0047       3      46 ..     132     176 ..     131     178 .. 0.94
   3 ?    1.4   0.7      0.14   4.2e+02       5      24 ..     185     203 ..     181     216 .. 0.78
   4 !    7.6   0.0    0.0016       4.8       2      34 ..     244     278 ..     244     290 .. 0.82
   5 !   10.0   0.0   0.00028      0.84       4      37 ..     326     362 ..     325     368 .. 0.87
   6 ?    1.0   0.0      0.19   5.7e+02       2       9 ..     432     439 ..     431     445 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.14
     Kelch_3  1 gdrlyifGGlg 11
                +d+lyif G +
  EFC38726.1 62 DDYLYIFMGSN 72
                69*******76 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 1.6e-06
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydldtntWaei..aslppaRaghaa 46 
                 +++++GGl  +g++ +n++y +d  t  W++   +++ p+  gh++
  EFC38726.1 132 EVFLYGGLK-QGRTLSNEFYGIDMKTFIWRRYisSQWLPGLEGHTI 176
                 589******.9*********************9999********98 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.14
     Kelch_3   5 yifGGlgddgqdrl.ndvyvy 24 
                 y++GG g  g+ +  n++y++
  EFC38726.1 185 YVYGGHG--GNLVFtNSFYRV 203
                 9******..766666999976 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.0016
     Kelch_3   2 drlyifGGlgd..dgqdrlndvyvydldtntWaei 34 
                 d +++fGG+ +   + + +nd + + + tntW ++
  EFC38726.1 244 DAMVVFGGKLRsgENAPMSNDSLIFYFKTNTWIKV 278
                 579********766699999999999999999765 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00028
     Kelch_3   4 lyifGGlgd...dgqdrlndvyvydldtntWaeiasl 37 
                 l+ fGG +    + qd++ dv+ +d++  tW+ +++l
  EFC38726.1 326 LLSFGGTCHtrdQPQDFTRDVLIFDVEELTWQVCDTL 362
                 7789****977677******************99876 PP

  == domain 6  score: 1.0 bits;  conditional E-value: 0.19
     Kelch_3   2 drlyifGG 9  
                 +++yifGG
  EFC38726.1 432 NSVYIFGG 439
                 789***** PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.1     0.021        64       9      27 ..      60      81 ..      55      89 .. 0.77
   2 ?    2.6   0.1      0.06   1.8e+02       7      40 ..     123     159 ..     120     167 .. 0.75
   3 ?   -3.4   0.3       4.9   1.5e+04      15      22 ..     185     192 ..     185     202 .. 0.69
   4 ?    3.0   0.0     0.047   1.4e+02      13      49 ..     245     284 ..     232     285 .. 0.73
   5 !    9.3   0.0   0.00049       1.5      12      43 ..     324     359 ..     313     365 .. 0.85
   6 !   10.1   0.1   0.00026      0.77       8      31 ..     426     451 ..     420     461 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.021
     Kelch_6  9 svggkiYifGGytds...spyl 27
                ++++++Yif G++     ++ +
  EFC38726.1 60 ICDDYLYIFMGSNIWhsfNSVV 81
                689******9998865555555 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.06
     Kelch_6   7 lvsvggk...iYifGGytdsspylnkvwvydpetksW 40 
                 ++ +++    ++++GG++++ + +n ++ +d++t  W
  EFC38726.1 123 ACYYDDDlkeVFLYGGLKQGRTLSNEFYGIDMKTFIW 159
                 56666532349********999999988888887666 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 4.9
     Kelch_6  15 YifGGytd 22 
                 Y++GG ++
  EFC38726.1 185 YVYGGHGG 192
                 99999876 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.047
     Kelch_6  13 kiYifGGytds....spylnkvwvydpetksWeqlpplpvp 49 
                   ++fGG   s     ++ +++++y ++t++W ++++  +p
  EFC38726.1 245 AMVVFGGKLRSgenaPMSNDSLIFY-FKTNTWIKVESTAIP 284
                 5689999999999977777776666.9*****999887666 PP

  == domain 5  score: 9.3 bits;  conditional E-value: 0.00049
     Kelch_6  12 gkiYifGGytds....spylnkvwvydpetksWeql 43 
                  k+  fGG ++       ++++v+++d+e  +W+ +
  EFC38726.1 324 TKLLSFGGTCHTrdqpQDFTRDVLIFDVEELTWQVC 359
                 58999***********999**************987 PP

  == domain 6  score: 10.1 bits;  conditional E-value: 0.00026
     Kelch_6   8 vs.vg.gkiYifGGytdsspylnkvw 31 
                  + ++ +++YifGG+++s + +++++
  EFC38726.1 426 SLdYNrNSVYIFGGSVCSVNGTRRWE 451
                 44444489*********955555554 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   0.1         6   1.8e+04      12      18 ..      62      68 ..      60      70 .. 0.82
   2 ?    3.4   0.1     0.026        76       7      43 ..     124     161 ..     116     166 .. 0.75
   3 ?    0.6   0.3      0.19   5.7e+02       4      24 ..     173     193 ..     173     202 .. 0.85
   4 !    8.1   0.0    0.0009       2.7       5      44 ..     235     278 ..     233     290 .. 0.70
   5 ?    3.9   0.0     0.018        53       8      45 ..     319     360 ..     314     367 .. 0.69
   6 !   10.4   0.1   0.00017      0.49       1      20 [.     419     439 ..     419     441 .. 0.87

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 6
     Kelch_4 12 dgtiylf 18
                d+++y+f
  EFC38726.1 62 DDYLYIF 68
                6999998 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.026
     Kelch_4   7 atsipd.gtiylfGGrgedgtllndlylldlstntWrr 43 
                 + +++d  +++l+GG     tl+n+ y +d +t  Wrr
  EFC38726.1 124 CYYDDDlKEVFLYGGLKQGRTLSNEFYGIDMKTFIWRR 161
                 456666679******99965788877777777777765 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.19
     Kelch_4   4 ghsatsipdgtiylfGGrged 24 
                 gh+++  ++g+ y++GG g++
  EFC38726.1 173 GHTIVKRRNGEYYVYGGHGGN 193
                 699999999********8876 PP

  == domain 4  score: 8.1 bits;  conditional E-value: 0.0009
     Kelch_4   5 hsatsipd.gtiylfGGrgedg...tllndlylldlstntWrrl 44 
                 h++ + ++ +  ++fGG    g     +nd  ++ ++tntW ++
  EFC38726.1 235 HQSLYFDKiDAMVVFGGKLRSGenaPMSNDSLIFYFKTNTWIKV 278
                 555555555666778886555555589**************666 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.018
     Kelch_4   8 tsipdgtiylfGGrgedg....tllndlylldlstntWrrlg 45 
                 + i   ++  fGG          +  d+ ++d++  tW+ + 
  EFC38726.1 319 VKISPTKLLSFGGTCHTRdqpqDFTRDVLIFDVEELTWQVCD 360
                 55555666666666653245557889999*********9764 PP

  == domain 6  score: 10.4 bits;  conditional E-value: 0.00017
     Kelch_4   1 pRaghsatsipd.gtiylfGG 20 
                 +R ++s+  +++ +++y+fGG
  EFC38726.1 419 GRNYFSMSLDYNrNSVYIFGG 439
                 599*******5559******* PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       4.2   1.2e+04      11      26 ..      62      72 ..      60      83 .. 0.63
   2 ?   -2.3   0.0       1.7   5.1e+03      14      21 ..     133     142 ..     132     162 .. 0.62
   3 ?    2.0   0.2     0.077   2.3e+02      12      29 ..     182     196 ..     173     201 .. 0.81
   4 ?    2.1   0.0     0.072   2.2e+02      15      45 ..     247     278 ..     244     281 .. 0.81
   5 ?    6.5   0.0    0.0029       8.8      13      42 ..     325     356 ..     314     360 .. 0.93
   6 ?    6.7   0.1    0.0026       7.7       5      20 ..     425     440 ..     423     459 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.2
     Kelch_2 11 ggkiyvvGGahtdnpn 26
                ++ +y++ G+     n
  EFC38726.1 62 DDYLYIFMGS-----N 72
                7788888777.....3 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.7
     Kelch_2  14 iyvvGGa..h 21 
                 ++++GG   +
  EFC38726.1 133 VFLYGGLkqG 142
                 6889998331 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.077
     Kelch_2  12 gkiyvvGGahtdnpnlss 29 
                 g  yv+GG+   ++nl++
  EFC38726.1 182 GEYYVYGGH---GGNLVF 196
                 566******...888776 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.072
     Kelch_2  15 yvvGGa.htdnpnlsssdvhvldlekhvWeev 45 
                 +v+GG   ++++   s+d  ++ +++++W +v
  EFC38726.1 247 VVFGGKlRSGENAPMSNDSLIFYFKTNTWIKV 278
                 566776667788888999999********887 PP

  == domain 5  score: 6.5 bits;  conditional E-value: 0.0029
     Kelch_2  13 kiyvvGGa..htdnpnlsssdvhvldlekhvW 42 
                 k++++GG    +d p ++++dv ++d e+ +W
  EFC38726.1 325 KLLSFGGTchTRDQPQDFTRDVLIFDVEELTW 356
                 99*******999*****************999 PP

  == domain 6  score: 6.7 bits;  conditional E-value: 0.0026
     Kelch_2   5 hsssvpggkiyvvGGa 20 
                 +s  + ++ +y++GG+
  EFC38726.1 425 MSLDYNRNSVYIFGGS 440
                 567899********** PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.1       0.4   1.2e+03      12      20 ..      60      68 ..      55      83 .. 0.78
   2 ?    8.3   0.1    0.0008       2.4      10      35 ..     123     150 ..     115     157 .. 0.77
   3 ?    3.8   0.2      0.02        60       6      35 ..     172     201 ..     169     206 .. 0.76
   4 ?    1.0   0.0      0.15   4.6e+02       6      25 ..     233     254 ..     227     273 .. 0.64
   5 ?   -3.1   0.0       2.9   8.6e+03      29      39 ..     341     351 ..     315     352 .. 0.49
   6 ?    6.3   0.3    0.0032       9.6       4      24 ..     419     441 ..     418     449 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.4
     Kelch_5 12 tvsekiYvy 20
                ++++++Y++
  EFC38726.1 60 ICDDYLYIF 68
                699*****9 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0008
     Kelch_5  10 avtvs...ekiYvyGGkvgrdgsvsddvy 35 
                 a++++    ++++yGG ++ +  +s+++y
  EFC38726.1 123 ACYYDddlKEVFLYGGLKQ-GRTLSNEFY 150
                 6665546789********7.999999999 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.02
     Kelch_5   6 aghcavtv.sekiYvyGGkvgrdgsvsddvy 35 
                  gh +v+  +++ YvyGG +g +  +++ +y
  EFC38726.1 172 EGHTIVKRrNGEYYVYGGHGG-NLVFTNSFY 201
                 5788887547888*****997.777788888 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.15
     Kelch_5   6 aghcavtvs..ekiYvyGGkvg 25 
                 a+h + + +  + + v+GGk  
  EFC38726.1 233 AYHQSLYFDkiDAMVVFGGKLR 254
                 4566666556777999***983 PP

  == domain 5  score: -3.1 bits;  conditional E-value: 2.9
     Kelch_5  29 svsddvyvLdl 39 
                 +++ dv+++d+
  EFC38726.1 341 DFTRDVLIFDV 351
                 33456666665 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.0032
     Kelch_5   4 pRaghcavtv..sekiYvyGGkv 24 
                 +R ++++  +   +++Y++GG v
  EFC38726.1 419 GRNYFSMSLDynRNSVYIFGGSV 441
                 689999999764599******76 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   1.5     0.083   2.5e+02      15      31 ..     185     202 ..     181     203 .. 0.86
   2 ?   -3.3   0.0       2.4   7.2e+03       7      13 ..     246     252 ..     245     253 .. 0.67
   3 ?   -0.4   0.0       0.3     9e+02      34      42 ..     270     278 ..     266     280 .. 0.78
   4 ?    9.2   0.0    0.0003       0.9      13      42 ..     325     359 ..     321     363 .. 0.88
   5 ?    1.2   0.1     0.091   2.7e+02      12      20 ..     432     440 ..     429     441 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.083
                 EEEEEBCS.SSBEEEEEE CS
     Kelch_1  15 YviGGsdg.gnalssvev 31 
                 Yv GG+ g   +++s+++
  EFC38726.1 185 YVYGGHGGnLVFTNSFYR 202
                 ********9888888876 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.4
                 EEEETTE CS
     Kelch_1   7 avvvggk 13 
                 +vv+ggk
  EFC38726.1 246 MVVFGGK 252
                 6777777 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 0.3
                 TTTTEEEEE CS
     Kelch_1  34 petntWrel 42 
                 ++tntW ++
  EFC38726.1 270 FKTNTWIKV 278
                 79****987 PP

  == domain 4  score: 9.2 bits;  conditional E-value: 0.0003
                 EEEEEEEBCS.....SSBEEEEEEEETTTTEEEEE CS
     Kelch_1  13 kiYviGGsdg.....gnalssvevyDpetntWrel 42 
                 k+  +GG ++     + ++++v ++D+e+ tW  +
  EFC38726.1 325 KLLSFGGTCHtrdqpQDFTRDVLIFDVEELTWQVC 359
                 67779***************************887 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.091
                 TEEEEEEEB CS
     Kelch_1  12 gkiYviGGs 20 
                 + +Y++GGs
  EFC38726.1 432 NSVYIFGGS 440
                 88******7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (495 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       436  (0.0243181); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.65u 0.36s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 2718.89
//
Query:       EFC38727.1  [L=131]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.1e-19   68.3   0.0    5.5e-19   68.2   0.0    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.2   0.0   3.1e-23   5.5e-19      12     121 .]       5     125 ..       1     125 [. 0.89

  Alignments for each domain:
  == domain 1  score: 68.2 bits;  conditional E-value: 3.1e-23
                  T.....SSEEEEEEECTTTEEEEEESS-...HHHHHHHHHHTTT-EEEEEEEEEECCS......ECCEEEEEEEEE--TTS-HHHHHHHHHHHHHHHH CS
  Cofilin_ADF  12 k....ktkyilfkidddkeeivveeege...tyeelreelpeseprYavydveyehdd......eskrsklvfIswvPdsapikqkmlyasskdalkk 96 
                  k    + k++++k++d+   i++++e +   t++el+ +lp ++ r+++y +++e +       e+ rsk++f++w+Pd++++ +k l+ +  + +kk
   EFC38727.1   5 KgvykDVKFLVLKMQDNF--IQIDAELTnlaTLDELIPKLPPKNTRFICYLLSFEMPTentqlrEGIRSKIMFLTWCPDETNVWEKFLFTAATNLVKK 100
                  44455899*******985..77777555679*********************9999888899999999***********99***************** PP

                  HCTTSEEEEEE-CGGCCSHHHHHHH CS
  Cofilin_ADF  97 elkgisveieatdldelteeelkek 121
                  ++kg++ +i+++  +e++e+ + ek
   EFC38727.1 101 KFKGMTGTIQCSHGSEIDESLMIEK 125
                  ******99***********987775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       513  (0.0286129); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 791.19
//
Query:       EFC38728.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-45  154.7   0.0    2.7e-45  154.4   0.0    1.1  1  ParBc_2         Putative ParB-like nuclease
  ------ inclusion threshold ------
      0.027   14.9   0.5      0.054   13.9   0.5    1.5  1  SUKH_6          SMI1-KNR4 cell-wall
      0.065   13.3   0.0        0.1   12.6   0.0    1.4  1  Staphostatin_B  Staphostatin B


Domain annotation for each model (and alignments):
>> ParBc_2  Putative ParB-like nuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  154.4   0.0   4.5e-49   2.7e-45       3     163 ..      58     236 ..      56     237 .. 0.94

  Alignments for each domain:
  == domain 1  score: 154.4 bits;  conditional E-value: 4.5e-49
                 EEGGGCB-SBSEE-HHHHHHHHHHHHT------.---TT-BEEEEEE-S.........TT-EEE-S-HHHHHHHHH..........TT-....-EEEEE CS
     ParBc_2   3 veiadLrPTQlavGldeveyklgeleelkekkkldkflekklvpvVigp.........dgelYliDhHHllralle..........sgvggaekkvlvk 82 
                 ++i d  PTQl +G+ + ++k+++leel+e+ ++ k lekk+vpvVigp         + +lY++DhHHl++a+++          s  + +e+ v+ +
  EFC38728.1  58 MKIVDAFPTQLPIGYVAAACKRDKLEELAENGDFFKQLEKKPVPVVIGPysnhqhthsNSSLYITDHHHLIYAIFMmrgsylppkyS--DITERYVYAT 154
                 789999***************************************************8889*************9966666665333..679******* PP

                 EEEE-TTS-HHHHHHHHHHTT--B-B-TTS-B--..GGGS-SSGGG-EE-HHHHHHHHHHHTTSS---.SSTTHHHHHHHHHH CS
     ParBc_2  83 vvadlsalskeeFwekmeeekwvhlydekgepls..veelPkslgeleddpyRsLaafvrdaggfkkekatpfaeFlWadflr 163
                 +++d+s+lsk++Fw+++ +++ +++yde g+pl+  +++lP+s++ l++dp+RsLa+f r++gg+ k  +++f+eF+Wa++lr
  EFC38728.1 155 IQRDYSTLSKTNFWNTLIKNNLTYTYDEFGKPLHnfPDSLPSSVMYLKNDPFRSLAYFDRRQGGYGKI-DQEFQEFSWANYLR 236
                 *********************************9999*****************************98.9************9 PP

>> SUKH_6  SMI1-KNR4 cell-wall
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.5   9.1e-06     0.054      15     117 ..     139     240 ..     135     242 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 9.1e-06
      SUKH_6  15 LPedYkeflkeynggefggnefigsseesivndaleilldegkeeeksefdeeedrlpenllpiaedgggdlicldyeendepkvvfwdseedgevekv 113
                 LP  Y +  + y   +++ ++ + s+ + +++   ++l++ ++e  k+ + + +d lp++++ + +d++  l ++d+++ + +k+    +e+++  ++ 
  EFC38728.1 139 LPPKYSDITERYVYATIQRDYSTLSKTNFWNTLIKNNLTYTYDEFGKPLH-NFPDSLPSSVMYLKNDPFRSLAYFDRRQGGYGKIDQEFQEFSWANYLR 236
                 67777777777777777777776555555555555555555555555444.88********************************99889999999999 PP

      SUKH_6 114 adsF 117
                 a+sF
  EFC38728.1 237 ANSF 240
                 9998 PP

>> Staphostatin_B  Staphostatin B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.7e-05       0.1      15      74 ..      93     152 ..      53     167 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.7e-05
                     -HHHHHHHHTT-EEEEETTTTEEEEEEE--TT-SSEEEEEEEETTTTEEEEEETTEEEEE CS
  Staphostatin_B  15 thleqtninlfignwsnhqlqksicirhgddtshnqyhilfidtahqrikfssidneeii 74 
                      +le+  + ++ig +snhq  +s    +  d  h  y i+++  ++   k+s i +  + 
      EFC38728.1  93 KQLEKKPVPVVIGPYSNHQHTHSNSSLYITDHHHLIYAIFMMRGSYLPPKYSDITERYVY 152
                     67999999*************************************999999999765543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       410  (0.022868); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1709.86
//
Query:       EFC38729.1  [L=249]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      0.002   18.2   0.0      0.003   17.7   0.0    1.2  1  F5_F8_type_C  F5/8 type C domain
     0.0028   17.7   0.0     0.0042   17.1   0.0    1.3  1  Sad1_UNC      Sad1 / UNC-like C-terminal


Domain annotation for each model (and alignments):
>> F5_F8_type_C  F5/8 type C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   3.3e-07     0.003      24     114 ..      56     145 ..      31     158 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 3.3e-07
                   S.SEEESSSSTTEEEEEEEEEEEEEEEEEEEECSSTTSSEEEEEEEEEESSSS..SEEEEEEECE.EESSSSSSSEEEEEEEEEEEEEEEEEEEE CS
  F5_F8_type_C  24 t.aWsssssddkqwlqvdLgkpkkidgvvtqgrqdggnayvksykiqvsddge..tWttvkdekv.pgnsdnstpvtntfdppvkaryvrltpts 114
                   + +W+ ++  ++++l ++L  + ++++++++  +   n  +k+  i++s d +  +++++      +++ ++++p +++f++pv+ +y++++ + 
    EFC38729.1  56 SlSWNNDDVVNQKTLLLELYLACNVRKIILDLDK---NSVPKEINISFSIDEKkiNFKKLTR--LrSTDLKRTRPFVISFSKPVQLKYLKFQFKL 145
                   357777777777999999**************97...889*********9954369999998..66778889*******************9875 PP

>> Sad1_UNC  Sad1 / UNC-like C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.0   4.7e-07    0.0042      55     131 ..      85     164 ..      66     165 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 4.7e-07
                 G...-TTSB-EEEEEEESSTT----EEEEEEE--TTS-SEEEEE--TT----EEEEEEEE--BS.S-SSEEEESEEEEEEE CS
    Sad1_UNC  55 p...isSapKdfevsgskrypekkwvllgefsydedgknaqtFeleeskdilvkyvkleilsny.GneeytclyrlrVyGt 131
                      +S pK++++s s ++++ + ++l++ + + d k++  F +  sk   +ky+k++++    +++  + l  l+VyGt
  EFC38729.1  85 LdldKNSVPKEINISFSIDEKKINFKKLTRLR-STDLKRTRPFVISFSKPVQLKYLKFQFKLLDeEQNGKCKLNSLKVYGT 164
                 234458**************************.99**************99*********986658999***********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (249 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       586  (0.0326845); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1403.63
//
Query:       EFC38730.1  [L=536]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-06   28.2   0.7    2.3e-06   27.5   0.7    1.4  1  MAPEG     MAPEG family


Domain annotation for each model (and alignments):
>> MAPEG  MAPEG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.7   1.3e-10   2.3e-06      37     126 ..     416     507 ..     308     511 .. 0.83

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 1.3e-10
                 ...........SH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.T-..HHHHHHHHHHHHHHHHHHHHHHHH-..SGGGHHHHHHHHHHHHHHHH CS
       MAPEG  37 a......pralddklppklqrairahgNflEyvplfllavllaeltgae..tglaallaaafvvaRvlhalgyiaggpppgRslgflltllvllvlsl 126
                 +      +++++     ++   +r+ +N++E++++    +l+++   +     +++ + ++f+++R+++ +gy+ +  + +R+lg+l+   ++++++ 
  EFC38730.1 416 PlltnliNKEHQL----RITIHQRVLQNSIEQFIMHSMGCLILGYYVSRenLRIIVFASITFLLCRIFFWIGYTIH--HSLRTLGMLTNACTTIAMLC 507
                 3443333455555....78889*****************99999974435589999999**************999..99**********99999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (536 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1947  (0.108595); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.32s 00:00:01.05 Elapsed: 00:00:00.51
# Mc/sec: 3132.24
//
Query:       EFC38731.1  [L=295]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      2e-54  181.5   4.2    3.4e-18   65.3   0.0    3.1  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.0   0.3   3.6e-20   6.5e-16       3      95 ..      10      94 ..       8      96 .. 0.93
   2 !   58.6   0.1   2.3e-20   4.2e-16       4      96 ..     105     192 ..     102     193 .. 0.95
   3 !   65.3   0.0   1.9e-22   3.4e-18       7      93 ..     201     293 ..     196     295 .] 0.88

  Alignments for each domain:
  == domain 1  score: 58.0 bits;  conditional E-value: 3.6e-20
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCT CS
   Mito_carr  3 lsvlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllk 95
                l+ ++ +  Ggl+g++at+v++P+d++Ktr+q+q++s         + ++++++k+eG++  y+Gl + +lr+  ++  ++++++ l+++l++
  EFC38731.1 10 LTSAQGFYFGGLSGMMATCVVQPVDLIKTRMQLQGGS--------PVTIVSNLIKQEGILRIYKGLDAGILRQLTYTTTRLGVFNALQDYLTT 94
                66788899*****************************........56689*************************************999875 PP

  == domain 2  score: 58.6 bits;  conditional E-value: 2.3e-20
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCTT CS
   Mito_carr   4 svlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllkk 96 
                 +++ ++++G++ag ++++v +P +v  +r+ + k ++++     + ++l +i k+eG+++l+rG +p+++r ++ +a+++++y + k++l k+
  EFC38731.1 105 NFAMKIVSGMVAGGIGAVVGNPAEVCLIRMTSGKFNYSH-----VGQALVRIAKDEGIKSLWRGTSPTVTRAVILNAAQLSFYSQAKEVLIKY 192
                 678899*************************99999988.....99********************************************997 PP

  == domain 3  score: 65.3 bits;  conditional E-value: 1.9e-22
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS......HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   7 kellaGglagavatlvttPldvvKtrlqtqkksskksksaa......ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrll 93 
                  ++++++++g ++t v  P+d++Ktrlq+ k+     + +        ldv+ k +k+eG+++l+rG++p +lr  p + l+fv+ e+++ ++
  EFC38731.1 201 CHCVSSLISGFASTAVSIPVDLAKTRLQSMKTVLDPVTGQMvpeykgPLDVITKAIKNEGILSLWRGFTPYFLRLGPHTLLTFVFLEQFRFMY 293
                 6899*************************777755555444666666*****************************************98665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       411  (0.0229238); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 1715.49
//
Query:       EFC38732.1  [L=925]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.8e-73  245.9  32.8    1.1e-72  245.4  32.1    1.5  1  Patched         Patched family
      3e-49  166.8  10.8      3e-49  166.8  10.8    2.7  3  Sterol-sensing  Sterol-sensing domain of SREBP cleavage-activ
      2e-06   27.0  34.5    0.00012   21.2   5.7    3.1  3  MMPL            MMPL family
  ------ inclusion threshold ------
       0.16   12.4   0.0        8.8    6.9   0.0    2.8  3  Pep1_7          Elicitor peptide 1-7


Domain annotation for each model (and alignments):
>> Patched  Patched family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  245.4  32.1   2.4e-76   1.1e-72      29     807 ..      80     878 ..      73     881 .. 0.81

  Alignments for each domain:
  == domain 1  score: 245.4 bits;  conditional E-value: 2.4e-76
     Patched  29 plkeekffpgkseekary..liitakdresknileesllnevvkindyisenveikedd..kitktfkdlCsry.....cdlncpvnkhvsm....... 111
                 ++k++++f ++  +  r   +ii  k+ +  n ++ ++++e+ +i+ +i + ++i + +    ++t  dlC +      c +++p++ +++m       
  EFC38732.1  80 TVKQKNYFDDQFSPFFRIeqMIIFPKNTSITNAINVDMMEELFQIQREIDS-IKIYDGNcsTAPITLDDLCYKPipskgCMIQSPLQ-FYQMnyntfet 176
                 56777888887777655543445555555589999***********99976.46666665678888999996531111155555543.44446776653 PP

     Patched 112 ..ellkrrhe......srlkltyPivkvlgtkiylgallggvkveeeegtlksakaivlqyflkldeeeveelskeyerelekllkdkyasehievsil 202
                       + ++      +r++l     +  g ++y ++++g v     ++  + a+a+++++ l+ +++++ e +  +e+e  k  ++  +    ++++ 
  EFC38732.1 177 gkN---QLVNhvylctQRISLSPICLSDIGIPLYDKQMFGKVSYNA-TTSYATAQALIVTILLN-NDNVTAERALLWEKEFLKVAQKPRTYS--TIYVS 268
                 321...2223566777888988666788999***********9999.99999999999999999.8889999999*****999998888877..77888 PP

     Patched 203 hsqiledelqrnaktllpflvvtiaiLlvfsiivsvvlssdalkidwvrskpilailgvlspvlAivsslGlllwlGfrfns.ivtvtPFLvLaiGvDd 300
                  +++++del +     +  + ++ a+++v+++i+    +        ++s++i+ ++gv+  v++iv s G+ ++ G++    i+ v+PFL+LaiGvD+
  EFC38732.1 269 AERSVQDELADETSGDISTVLISYAVMFVYVAISLGQIHP-------IKSRIIMGLAGVIIVVMSIVISAGICCLAGVPATLiIMEVMPFLILAIGVDN 360
                 999******************************9999888.......********************************8761678************* PP

     Patched 301 mflmvaawkrteakls....vkkrigealseagvaitiTslTdvlsFgiGaittlpaiqlFciytavailfdfiYqitffaavlaiaakaeaegrhsll 395
                 mf+m++  +++ +++     v + i+e+++ +g+++t+ s+ + l+F +G +t++pa+q Fci+ +vai+ +f+ q+t f+a+l++  ++  ++r  l 
  EFC38732.1 361 MFIMANHLDQVVKRKGskltVAEAIAETMATVGSSMTLASISEFLAFMLGSLTKMPAVQAFCIFSGVAIIANFVLQVTCFSALLSLDLRRRLSNRLELE 459
                 ******998877665556779***********************************************************************9997776 PP

     Patched 396 liiekeespsklqeiesessekdddkskeaee.lkskffreiyapfllnksvrlvvlllfvvylaiaiyGcvnikegLepkklvledsplvevlkliek 493
                 +++           i ++  ++  d    ++    + ++++i+ap ++   v +++l++f+     +iy  + + +gL+   ++   s+l e++ +  +
  EFC38732.1 460 PTVV----------ITNKYFTR--D--WISIAgGARFIMKKIIAPIVTFLPVSFFILIVFLGLCGASIYASMFLSQGLDQITALPTGSYLGEYFLKQ-R 543
                 6633..........55555555..2..22223235678999****************************************************9865.8 PP

     Patched 494 eiwkeglqvevvvnNppdltikesrdrleelveefentpyalgkkstkfwlreyekflkqseleveeledeee...............ewskeele.sf 576
                 e +  g  v  v +N  d t ++ +d++ ++++  ++t+y l + s  f+  +++k+  +   e + +++  +               + + e+ + +f
  EFC38732.1 544 EYVDLGPPVYYVTKNL-DYTSHAVQDQMSRMMNIVAETEY-LDRGSILFFYTDFKKWVLS--NECSHKNVSAShvppehyvewlkeflQ-QEECCKiNF 637
                 88999*9999877775.99****************99988.688999*********9855..444444544445677566644443211.111111133 PP

     Patched 577 lkaaensl.wkkdlvwdnesdeettelkkfrftlalkdlseptdrtkllke......lRsiadkese......lnvtvfdedaafadqlltilpstiqn 662
                 + ++   + +k+d+++      ++ ++ + r+ +  k l++ +d  +++k+        s  +k+s+      l+   +  ++ +  q+l +      n
  EFC38732.1 638 QVVPLCGFqFKQDVKFS----ADGKSIDAARLMTQTKTLVTQEDFINSMKSsyftstYLSNPQKYSPtsgfgpLETYPYSIYYIYFAQYLYLPEISAMN 732
                 34433333345555554....77788888888888888877777666665522100034444555547787779999***************99999** PP

     Patched 663 ivlallcmfvvallfipelitvlvitlsivsidigviGflslWgvdLDpismitiimsiGfsvdlsaHiayafvrsekddakeRvvealealgwPvvqg 761
                 i++a   +f+  l+++ ++++++++ + i  i   ++G++++Wg+   ++s+++++msiG sv++  Hi+ af+++++ + k+Rv++a+ ++g  v+ g
  EFC38732.1 733 IMIASGAVFLTTLILLGSPVASIYVLICISMILTNLLGIMAVWGIYVNALSVVNLVMSIGISVEFCVHITRAFMKARG-THKDRVKKAMIEMGSSVLSG 830
                 ******************************************************************************.******************** PP

     Patched 762 alST.ilgvlvLlfvdsymvqvFfktvvLvvvi.gllHgLlilPills 807
                  + T ++gv+vL+f  s + +++   + L++v+ g+lHgLl+lP ll 
  EFC38732.1 831 ITFTkFIGVIVLAFSHSELFRIYYFRMYLSIVVsGALHGLLFLPSLLL 878
                 9887689***************9877877765439*********9986 PP

>> Sterol-sensing  Sterol-sensing domain of SREBP cleavage-activation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.5       2.2     1e+04      32     127 ..      36      50 ..      29      62 .. 0.51
   2 !  166.8  10.8   6.7e-53     3e-49       2     147 ..     309     458 ..     308     464 .. 0.93
   3 ?    1.8   8.8     0.042   1.9e+02      11     131 ..     756     874 ..     751     881 .. 0.64

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.2
                     HHHHHHHHHHHHHHHHHHCHHCCHHCHHHHHHHHTTTCHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH CS
  Sterol-sensing  32 ltltliilevlPflvlavgvdnifvlvkavqrtsrsldeseriaealgevgpsilltsltellalllgaltdvpavqeFclfaavavlvdFllqi 126
                     + + ++++    f+v+a                                                                              
      EFC38732.1  36 YATATVPI---LFIVIA------------------------------------------------------------------------------ 49 
                     44444444...344444.............................................................................. PP

                     T CS
  Sterol-sensing 127 t 127
                     +
      EFC38732.1  50 V 50 
                     4 PP

  == domain 2  score: 166.8 bits;  conditional E-value: 6.7e-53
                     HHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHCCHHCHHHHHHHHTTTCH....HHHHHHHHHHHCCCCHHCCCHH CS
  Sterol-sensing   2 vkskfgLglagviivllsvasslgllaylgltltliilevlPflvlavgvdnifvlvkavqrtsrslde....seriaealgevgpsilltslte 92 
                     +ks++++glagviiv++s++ s g++ + g+++tlii+ev+Pfl+la+gvdn+f++ + ++++ +++       e iae++ +vg s++l s++e
      EFC38732.1 309 IKSRIIMGLAGVIIVVMSIVISAGICCLAGVPATLIIMEVMPFLILAIGVDNMFIMANHLDQVVKRKGSkltvAEAIAETMATVGSSMTLASISE 403
                     79*******************************************************9877666555444455********************** PP

                     HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHHHHHHHHHCTXXTT CS
  Sterol-sensing  93 llalllgaltdvpavqeFclfaavavlvdFllqitfFvavLsldirreeserldv 147
                     +la++lg+lt++pavq+Fc+f+ va++ +F+lq+t+F+a+Lsld+rr++s+rl++
      EFC38732.1 404 FLAFMLGSLTKMPAVQAFCIFSGVAIIANFVLQVTCFSALLSLDLRRRLSNRLEL 458
                     ***************************************************9986 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.042
                     HHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHCCHHCHHHHHHHHTTTCHHHHHHHHHHHHCCCCHH.CCCHHHHHHHHHHHCCH CS
  Sterol-sensing  11 agviivllsvasslgllaylgltltliilevlPflvlavgvdnifvlvkavqrtsrsldeseriaealgevgpsill.tsltellalllgaltdv 104
                       +i++ + ++  lg++a+ g+ ++ +++ v   + + ++v+    +++a+ +   ++  ++r+++a+ e+g s+l+  ++t+++  ++ a+++ 
      EFC38732.1 756 YVLICISMILTNLLGIMAVWGIYVNALSV-VNLVMSIGISVEFCVHITRAFMKARGTH--KDRVKKAMIEMGSSVLSgITFTKFIGVIVLAFSHS 847
                     45566777777779************999.6655666666676667777776665555..58888888888888765223344443333334444 PP

                     HHHHHHHHHHHHHHHHHHHHHHTHHHH CS
  Sterol-sensing 105 pavqeFclfaavavlvdFllqitfFva 131
                        + + +   ++++v+ +l+ ++F+ 
      EFC38732.1 848 ELFRIYYFRMYLSIVVSGALHGLLFLP 874
                     444444444445667777777777765 PP

>> MMPL  MMPL family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   1.1      0.12   5.2e+02     168     194 ..      37      63 ..      30      68 .. 0.79
   2 !   17.1  12.7   4.6e-07    0.0021     115     305 ..     254     450 ..     216     476 .. 0.76
   3 !   21.2   5.7   2.6e-08   0.00012     149     310 ..     733     889 ..     725     905 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.12
        MMPL 168 vaallplltvvvsllaalglvlilall 194
                 ++a++p+l +v+ ++ + g+ + ++++
  EFC38732.1  37 ATATVPILFIVIAVIFTAGIGVGIKNI 63 
                 7999***************95555555 PP

  == domain 2  score: 17.1 bits;  conditional E-value: 4.6e-07
        MMPL 115 eear.pleglkvevtGpaatladlrdasdrdlklievvtlvvilviLliv......yrSlvaa.llplltvvvsllaalglvlilalllglelstfvlg 205
                 + a+ p +  +++v+    + ++l+d ++ d+ ++ + + +v +v  +i        +S +++ l  ++ vv+s++++ g+      l+g+  +  ++ 
  EFC38732.1 254 KVAQkPRTYSTIYVSAERSVQDELADETSGDISTVLI-SYAVMFVYVAISlgqihpIKSRIIMgLAGVIIVVMSIVISAGI----CCLAGVPATLIIME 347
                 4444567788999999999999999998888876654.4444444444440111223454444044589999999999999....5578899999999* PP

        MMPL 206 llvvlliavGtDYallLvsRyreelaagedr....eeaviravastgkvvtaaGltvaiamlgLvvarlpvlaqvGvaialGvlvdvlivlTllPAllv 300
                  +  l++a+G+D ++++++ + +++ + + +    +ea+++++a++g+  t a +   +a++  +++++p+++++ +  +++++  + + +T   All+
  EFC38732.1 348 VMPFLILAIGVD-NMFIMANHLDQVVKRKGSkltvAEAIAETMATVGSSMTLASISEFLAFMLGSLTKMPAVQAFCIFSGVAIIANFVLQVTCFSALLS 445
                 ************.99*999999988665443112278******************988888888*********************************99 PP

        MMPL 301 llGra 305
                 l  r+
  EFC38732.1 446 LDLRR 450
                 85554 PP

  == domain 3  score: 21.2 bits;  conditional E-value: 2.6e-08
        MMPL 149 evvtlvvilviLlivyrSlvaallplltvvvsllaalglvlilalllglelstfvlgllvvlliavGtDYallLvsRyreelaagedreeaviravast 247
                 ++++   +++  li+++S+va +++l+ + + l   lg+++++        + +v++l  v+ i++++ +++ ++  +  +++ ++dr   v +a+  +
  EFC38732.1 733 IMIASGAVFLTTLILLGSPVASIYVLICISMILTNLLGIMAVWGIY---VNALSVVNL--VMSIGISVEFCVHITRAFMKARGTHKDR---VKKAMIEM 823
                 567777899999***************************8888654...233455555..45677788*****9999***********...******** PP

        MMPL 248 gkvvtaaGltva..iamlgLvvarlpvlaqvGvaialGvlvdvliv.lTllPAllvllGraa.lakp 310
                 g+ v+ +G+t+   i ++ L+++  + ++   + + l+++v+ ++  l +lP+ll ++G  + ++++
  EFC38732.1 824 GSSVL-SGITFTkfIGVIVLAFSHSELFRIYYFRMYLSIVVSGALHgLLFLPSLLLIAGPQQdPVAK 889
                 ***96.8988853378888********************999766515556********99766544 PP

>> Pep1_7  Elicitor peptide 1-7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.0     0.002       8.8       7      37 ..       8      38 ..       3      42 .. 0.84
   2 ?   -2.7   0.0       1.9   8.4e+03      19      36 ..     795     812 ..     791     819 .. 0.80
   3 ?    1.9   0.0     0.068     3e+02      34      64 ..     881     911 ..     871     917 .. 0.66

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.002
      Pep1_7  7 redeksyylwipfsfihqilraflkclGLes 37
                ++ + syyl +p + +++i+r+++  +G+ +
  EFC38732.1  8 NQKGLSYYLSLPSYYLDKIFRTIFYYIGYAT 38
                455789******************9888765 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.9
      Pep1_7  19 fsfihqilraflkclGLe 36 
                  +f+  i raf+k  G +
  EFC38732.1 795 VEFCVHITRAFMKARGTH 812
                 67999999****998865 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.068
      Pep1_7  34 GLesssskspsssseeeeeetetvevtsrgl 64 
                 G + ++  +   ++e+eeee+ +v+++ r  
  EFC38732.1 881 GPQQDPVAKIKGEEEDEEEEQADVNIEGRTG 911
                 5555566666667777788888888887755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (925 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       993  (0.0553851); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.80u 0.34s 00:00:01.14 Elapsed: 00:00:00.51
# Mc/sec: 5412.14
//
Query:       EFC38733.1  [L=897]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.9e-14   51.9   0.4    1.3e-13   50.6   0.4    1.7  1  Bac_rhamnosid_C  Bacterial alpha-L-rhamnosidase C-terminal do
    1.7e-13   50.6   0.7    3.9e-10   39.5   0.1    2.9  2  Bac_rhamnosid6H  Bacterial alpha-L-rhamnosidase 6 hairpin gly
  ------ inclusion threshold ------
      0.014   15.5   1.9       0.02   15.1   0.1    2.3  2  Laminin_G_3      Concanavalin A-like lectin/glucanases superf


Domain annotation for each model (and alignments):
>> Bac_rhamnosid_C  Bacterial alpha-L-rhamnosidase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.6   0.4   2.1e-17   1.3e-13       1      65 [.     743     806 ..     743     816 .. 0.95

  Alignments for each domain:
  == domain 1  score: 50.6 bits;  conditional E-value: 2.1e-17
                      --EECCGGGTEEEE----BTTB-EEEEEEEETTEEEEEEEEEETTEEEEEEEE-TT-EEEEEEE- CS
  Bac_rhamnosid_C   1 GirpsepGfkkiviaPkpggdlksvkasfeslyGkikvdWkredgkftlnvsvPanttaeVvLpg 65 
                      Girp+++G+ ++v++P+ g+ l+++k++++++ Gk++v W+ +++ f+++v+vP+ ++ +VvL +
       EFC38733.1 743 GIRPTSTGYSEWVVKPQTGS-LTWAKGAVQTPNGKLSVYWSNSNNLFSITVEVPPKSKGTVVLQQ 806
                      9*****************99.*****************************************976 PP

>> Bac_rhamnosid6H  Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.1   0.00022       1.3       3      29 ..     188     214 ..     186     218 .. 0.92
   2 !   39.5   0.1   6.4e-14   3.9e-10      27     340 .]     404     741 ..     396     741 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00022
                      -EEEEES-HHHHHHHHHHHHHHHHTBS CS
  Bac_rhamnosid6H   3 tgsfecsdpllnrlhenvlwsvrsnfl 29 
                       g f+cs++++n+++++ +++ + n++
       EFC38733.1 188 NGAFSCSNEVYNKMWNMGVRTLQLNMV 214
                      699********************9996 PP

  == domain 2  score: 39.5 bits;  conditional E-value: 6.4e-14
                      TBSSSB-S-SSSS----BHHHHHHHHHHHHHHB--HHHHHHHHHHHHHH--TTS--BSBSS--T............T--B--TTTTTHHHHHHH CS
  Bac_rhamnosid6H  27 nflgvptDCPqrdErlgWtgdaqlfaptasylydveaflekwlrdladeqrengavptvaPevl............galsetaeWadaivivpw 108
                      n + v  D+ +r  r+ W gd  +  p  +y y ++++++ +l    + q ++g v   + + +             ++  + +   a +++ +
       EFC38733.1 404 NPVAVILDGAKR-DRNVWSGDLLVAGPLLYYSYYANEYASGTLGICTSYQLKSGFVSSRIGTGFpyqtidpsddfvTPIFYSYTYFLASLSAIE 496
                      66778899****.9***************************************8554443333333336666557777788888889999999* PP

                      HHHHHH--HHHHHHHHHHHHHHHHHHHHTSBT..TB..--S-S--STT.....-SS----HHHH.HHHHHHHHHHHHHHHHHHTTS..--HHHH CS
  Bac_rhamnosid6H 109 elyetygDkeilkkqYesmkryldylkqrsdd.gle.elskfqlgDWldpeardgaaktekalv.ataylvrslklvakiaellgkeedakkya 199
                      e+y ++gD +++k+q++ +k  ++  ++ + + gl  + + +   D++     ++     ++++  ++ ++++++ ++ +a+++g+++ a++y 
       EFC38733.1 497 EYYLYSGDLSFVKEQWTRLKLLINAFDSLKGSdGLLqGVNPNWTYDFY-----PSLGMLLGRFTkLNIQYAMAMESASVLAKAVGETNLAETYL 585
                      ***********************9999877664555355555556888.....5555555555534778888899999999************* PP

                      HHHHHHHHHHHHHHB.-TTS-BTT--......HHHHHHHHHTT-S-GGGH.....HHHHHHHHHHHHHTTS-----TTTHHHHHHHHHH..... CS
  Bac_rhamnosid6H 200 alaeelkaafnkkyldsetgsvandt......qtanalpLafglvpeaera....akvaerlvkkveenknhlstGfvGtpillrvLse..... 278
                       +a+  k+  n+k++d+++g++  +       q  na+++  g+   + r     ++  +++ +++++  n l++  +G+++  + +s      
       EFC38733.1 586 IRANSTKQLVNEKLFDTNSGTYIISDqksgiaQDTNAFAILSGIA--SLRGknfsSTLLDTMKDQLKSGSNYLTFKNAGASFTSPYISYfhaaa 677
                      ********************5543332345557788888888888..44440000555555666666777888888888776655443211111 PP

                      ...TT-HHHHHHHHH--SSSSSHHHHHTT-SS--SSTTSB-...--TTS--S--SGGGGGHHHHHHHT CS
  Bac_rhamnosid6H 279 ...ngeedlayalllqeeypswgymvknGaTtiwErWdsml...npkemnSfnHyalgavaewlyenv 340
                         +++ed a++++++     w  m  +G   +  +W+s+     ++++nSf H++ g v+ +l ++v
       EFC38733.1 678 afeSNREDHAFDIINS----VWTPMTVEGPYFTNAFWESIEigaTQSASNSFAHAWSGGVSPLLSKYV 741
                      1226666666666654....6888999998777777777666669999************99988775 PP

>> Laminin_G_3  Concanavalin A-like lectin/glucanases superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   0.1   3.3e-06      0.02      67     116 ..     303     352 ..     245     381 .. 0.72
   2 ?   -3.1   0.2       1.3   7.9e+03      56      74 ..     751     769 ..     705     794 .. 0.50

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 3.3e-06
  Laminin_G_3  67 aeesvtsgasvpageWtHvavtydggtlrlYvNGvevgsatltggllsat 116
                  + ++ ts  ++ +++W+ v + ++   +++Y++G+++   +l+++++++ 
   EFC38733.1 303 TLYYNTSLPNLVENQWYDVFASVNQLVFKVYIDGALIFDINLPQSTNPYI 352
                  3457789999**************************99998888766554 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.3
  Laminin_G_3  56 rlrfsvnagngaeesvtsg 74 
                  + ++ v+ ++g+ +++ ++
   EFC38733.1 751 YSEWVVKPQTGSLTWAKGA 769
                  3333333333333333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (897 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       376  (0.0209716); expected 358.6 (0.02)
Passed bias filter:                      273  (0.0152267); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 5254.85
//
Query:       EFC38734.1  [L=324]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-19   70.1   0.0    3.7e-19   68.8   0.0    1.7  2  GST_N_2   Glutathione S-transferase, N-terminal domain
    1.2e-09   38.0   0.0    5.2e-09   36.0   0.0    2.1  3  GST_C_2   Glutathione S-transferase, C-terminal domain
    1.6e-06   28.2   0.0    2.6e-06   27.5   0.0    1.4  1  GST_C     Glutathione S-transferase, C-terminal domain
     0.0038   17.6   0.1      0.091   13.2   0.1    2.3  1  GST_N_3   Glutathione S-transferase, N-terminal domain


Domain annotation for each model (and alignments):
>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.8   0.0   8.3e-23   3.7e-19       1      69 [.      53     148 ..      53     149 .. 0.86
   2 ?   -2.6   0.0       1.5   6.9e+03      35      47 ..     291     307 ..     256     308 .. 0.67

  Alignments for each domain:
  == domain 1  score: 68.8 bits;  conditional E-value: 8.3e-23
                 S-HHHHHHHHHHHHCT--EEEEEE.H...-TTSHHHHH.........................HHHCTTTSSSEEE-CTTE..EEESHHHHHHHHHH CS
     GST_N_2   1 aCPwahRvlialalkglediisvv.vlepkgfekseef.........................prlnprgtVPvLwdkdgq..vineSseIlrylet 69 
                 aCPw+hR+ +++ lkgle ii vv v+++ g+e ++ f                         p++ ++ tVPvL dk++   v+neSseI+r++++
  EFC38734.1  53 ACPWCHRTDLVRTLKGLEKIIPVVfVDNFLGEE-GWRFghegdqdtisgldakflreiylqsnPNYEGKITVPVLYDKKQHliVNNESSEIIRMMND 148
                 7**********************8855555544.444555669999999999999999999989999999*******98889*************98 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.5
                 HHH....HHHCTTTSSS CS
     GST_N_2  35 eef....prlnprgtVP 47 
                  ++     r+n++g VP
  EFC38734.1 291 KHYfgshRRINGFGIVP 307
                 33334447888888888 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0         1   4.6e+03      42      50 ..      55      63 ..      45      74 .. 0.71
   2 ?   -3.4   0.0       2.2     1e+04      54      67 ..     165     178 ..     154     178 .. 0.74
   3 !   36.0   0.0   1.2e-12   5.2e-09       1      68 [.     195     270 ..     195     271 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1
                HHHHHHHHH CS
     GST_C_2 42 pflvrlraa 50
                p+++r++ +
  EFC38734.1 55 PWCHRTDLV 63
                788887765 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.2
                 ----TT-HHHHHHH CS
     GST_C_2  54 fdireaypnlraWl 67 
                  ++r++  ++++W+
  EFC38734.1 165 SELRSEIDKVNEWV 178
                 47888899999996 PP

  == domain 3  score: 36.0 bits;  conditional E-value: 1.2e-12
                 HHHHCHHHHHCCHCHHHCTTT---SS.CTTC..S--HHHHHHHHHHHHHHHHHHS-......---TT-HHHHHHHH CS
     GST_C_2   1 eaaveraleqldaaldaleahLadspflfGd..qptlaDialapflvrlraagpgf......direaypnlraWle 68 
                 ++a+e+a  +l+++ld+le++L  ++f+  +  + t aD +l p+l r++ +++ +       +r++ypn+  +++
  EFC38734.1 195 QQAYEEAFHALFKTLDELENILSSQRFIVKGskHVTEADLRLLPTLLRFDIVYYTHfkcnlkSLRHGYPNIYNYMK 270
                 5789999999****************999999********************99888**999999*********97 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.0   5.8e-10   2.6e-06      18      92 ..     192     275 ..     146     276 .. 0.84

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 5.8e-10
                 HHHHHHHHHHHHHHHHHHHHHHHHHHTSSSSS..TTSSCHHHHHHHHHHH.....HHHHHTTTTT..TTTSHHHHHHHHHHHTS CS
       GST_C  18 ekkeelvdealekvaevlsaleeelkkqdylv..GdkltlADialvpiln.....wlqrlglafg..qekfpnlkawlerimar 92 
                 ++k+++++ea+ ++++ l+ le+ l+ q ++v    ++t AD+ l+p l+     ++ +++ +++  + ++pn++ ++++++++
  EFC38734.1 192 AQKQQAYEEAFHALFKTLDELENILSSQRFIVkgSKHVTEADLRLLPTLLrfdivYYTHFKCNLKslRHGYPNIYNYMKEVYQL 275
                 56999**************************953457***********9988855555555555599*************9886 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.1     2e-05     0.091       4      71 ..      51     150 ..      48     155 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2e-05
                 -TTSHHHHHHHHHHHHHT--....EEEE---...........................TTTTHHHHHHH-TT--SSEEETTS-...EEESHHHHHHHHH CS
     GST_N_3   4 fpaSpyarrvrlaLnekglp....vevvevt...........................pgehdeellaknplgkvPvLeddge...altdSlaIidyLe 68 
                 ++a+p++ r  l+ ++kgl+    v +v  +                            +   ++ +++ ++ +vPvL+d  +   +  +S++Ii+   
  EFC38734.1  51 AYACPWCHRTDLVRTLKGLEkiipVVFV--DnflgeegwrfghegdqdtisgldakflREIYLQSNPNYEGKITVPVLYDKKQhliVNNESSEIIRMMN 147
                 7899999999999999999545334444..2346777778888887878877665333333355555555889******9977666667******9887 PP

                 HHH CS
     GST_N_3  69 ely 71 
                 +++
  EFC38734.1 148 DQF 150
                 776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (324 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       808  (0.0450667); expected 358.6 (0.02)
Passed bias filter:                      678  (0.0378158); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1843.08
//
Query:       EFC38735.1  [L=584]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-45  155.1  41.7    5.6e-25   87.9  12.9    2.9  3  MatE             MatE
      0.009   16.1  14.0      0.009   16.1  14.0    4.0  4  Polysacc_synt_C  Polysaccharide biosynthesis C-terminal domai
  ------ inclusion threshold ------
      0.012   14.5   0.6      0.012   14.5   0.6    3.2  4  MscS_TM          Mechanosensitive ion channel inner membrane 
      0.088   13.0   0.1      0.088   13.0   0.1    1.9  2  MAP17            Membrane-associated protein 117 kDa, PDZK1-i
       0.22   11.3   1.4       0.77    9.6   1.4    1.9  1  Vpu              Vpu protein
       0.71    9.9   7.2       0.23   11.5   2.1    2.6  3  AlaE             L-alanine exporter
       0.82    9.9   6.2         13    6.1   0.7    3.0  2  Adeno_E3B        Adenovirus E3B protein


Domain annotation for each model (and alignments):
>> MatE  MatE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.1  12.4   5.5e-26   1.4e-22       1     161 []     113     273 ..     113     273 .. 0.99
   2 !   87.9  12.9   2.2e-28   5.6e-25       3     159 ..     345     502 ..     343     504 .. 0.98
   3 ?   -2.3   1.2       1.2     3e+03      76      98 ..     516     537 ..     513     544 .. 0.62

  Alignments for each domain:
  == domain 1  score: 80.1 bits;  conditional E-value: 5.5e-26
        MatE   1 Pialenllesllslidtllvgrl.gskalAavsialsilsllfvfllglstalttlvgqalGaknfkrakealrqglilllllsliiallvllfseqil 98 
                 Pi+l+n+   +l++ d +++g+l  s+ +A+ ++++ i++ l ++++g+ ++ +t+v+qa+Gakn+  +++ +++++i+l+l+ l+++++ l+f e il
  EFC38735.1 113 PIILMNVSNKMLGIEDLMFIGHLgNSQYMAGSALGNAIFFSLSFIAVGIISGQDTFVAQAFGAKNKPLVGVWMMRSFITLILFLLPVMVV-LFFLESIL 210
                 9**********************9999***************************************************************.******** PP

        MatE  99 slftqdeevlelakrylrililgipalalqlvlsgilrgagktkvplyislislllniplnyl 161
                  l++ de  ++l+ +++r+l++g++++a++  ++++l ++ +  + + i ++++++n+ ln+l
  EFC38735.1 211 NLVGMDEVTSHLSGQFVRYLLPGLIPFAFSRSTARFLTSVNIRLPNTLIPIAAVIVNFGLNWL 273
                 *************************************************************96 PP

  == domain 2  score: 87.9 bits;  conditional E-value: 2.2e-28
        MatE   3 alenllesllslidtllvgrlgskalAavsialsilsllfvfllglstalttlvgqalGaknfkrakealrqglilllllsliiallvllfseqilslf 101
                  + +++e++ + ++t++++ ++++ +Aa+si+++i+sl f+++l+ls+a  ++vgq lG++++ +ak a++ +++ +++++ +   ++ ++s++i  l+
  EFC38735.1 345 TIGVCAEVWAFEFTTIVASFISAVQVAAHSIVFNIASLSFMLPLALSNASCVMVGQKLGSNDPSGAKYAAYLCIFSSVVCMSVSGTIIGICSRWIPLLY 443
                 5789*********************************************************************************************** PP

        MatE 102 tqdeevlelakrylrililgipalalqlvlsgilrgagktkvplyislisl.llnipln 159
                 t+de v ++a+ +l+i+ ++++++++q +++g+lrga+ + ++++++li++ l+ +p++
  EFC38735.1 444 TTDESVRSVASSILPIISVFAIVDGIQRTSTGVLRGASSQFLTMILNLIAYyLFSLPVS 502
                 *****************************************************999986 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.2
        MatE  76 lilllllsliiallvllfseqil 98 
                 l+l+l  + +++++ ++++ +i+
  EFC38735.1 516 LWLGLTSCMVLMAV-IVLIYIIF 537
                 66666666666666.55555554 PP

>> Polysacc_synt_C  Polysaccharide biosynthesis C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   3.7       1.8   4.7e+03      57     114 ..     143     199 ..     125     215 .. 0.43
   2 !   16.1  14.0   3.5e-06     0.009       3      77 ..     228     307 ..     226     384 .. 0.82
   3 ?   -2.1   1.1       1.4   3.6e+03      94      94 ..     388     388 ..     344     441 .. 0.51
   4 !    7.2   9.1     0.002       5.1       1      81 [.     456     539 ..     456     549 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.8
  Polysacc_synt_C  57 Gaaiatvlallvvavlnlyalrrllgiklellrrllkpllaalvmgivvylllllllg 114
                      G a++ ++ + ++++   ++  + + +    +    kpl+ + +m   ++l+l ll+ 
       EFC38735.1 143 GSALGNAIFFSLSFIAVGIISGQDTFVAQ-AFGAKNKPLVGVWMMRSFITLILFLLPV 199
                      44444444444444443333333333333.2222235665555555553322222222 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 3.5e-06
  Polysacc_synt_C   3 ailalsiiflslstvlssiLqglgrqkialkalvigalvklilnllliplfgi.....vGaaiatvlallvvavlnlyal 77 
                      ++l +++i++++s+ ++  L++++     +++ +++++v+++ln+l++  +g      +Gaaiat+l+ l++++  +y l
       EFC38735.1 228 RYLLPGLIPFAFSRSTARFLTSVNIRLPNTLIPIAAVIVNFGLNWLFVFGIGFkgigfLGAAIATTLTRLFIIFSYIYVL 307
                      7899********************************************5443366666*********9988887766554 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.4
  Polysacc_synt_C  94 p 94 
                      +
       EFC38735.1 388 L 388
                      1 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.002
  Polysacc_synt_C   1 vLailalsiiflslstvlssiLqglgrqkialkalvigal.vklilnllli..plfgivGaaiatvlallvvavlnlyalrrll 81 
                      +L i+++ +i+ +++++++++L g   q ++++ ++i+   + l ++ ll    ++ ++G  ++ + +++++av+ l+++  ++
       EFC38735.1 456 ILPIISVFAIVDGIQRTSTGVLRGASSQFLTMILNLIAYYlFSLPVSSLLAfvAKLELLGLWLGLTSCMVLMAVIVLIYIIFRI 539
                      6889***************************998888864488999888886689999******************99987665 PP

>> MscS_TM  Mechanosensitive ion channel inner membrane domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   1.1    0.0073        19      45     100 ..     187     242 ..     128     246 .. 0.71
   2 ?   -4.3   0.7       2.5   6.4e+03      55     102 ..     342     389 ..     341     395 .. 0.64
   3 ?   -1.1   0.1      0.26   6.7e+02      25      64 ..     469     508 ..     448     515 .. 0.62
   4 ?   14.5   0.6   4.8e-06     0.012     230     293 ..     520     578 ..     507     583 .. 0.71

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.0073
     MscS_TM  45 rallltlllalPlplllaaiglllqeaaqaepfaaalgaallaaalvllvfellra 100
                 r ++  +l  lP+ ++l+++  +l+  +  e +++  g+++  + + l++f++ r+
  EFC38735.1 187 RSFITLILFLLPVMVVLFFLESILNLVGMDEVTSHLSGQFVRYLLPGLIPFAFSRS 242
                 34444455555777777777777777777777777777777777777777777766 PP

  == domain 2  score: -4.3 bits;  conditional E-value: 2.5
     MscS_TM  55 lPlplllaaiglllqeaaqaepfaaalgaallaaalvllvfellrall 102
                 +P+++ + a  ++++  +   +f +a+  a +++++ +  +++++ l+
  EFC38735.1 342 IPGTIGVCAEVWAFEFTTIVASFISAVQVAAHSIVFNIASLSFMLPLA 389
                 566666666667777777777777777777777777776666666555 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.26
     MscS_TM  25 leklaervgkvkqDsflhTlrallltlllalPlplllaai 64 
                 ++++++ v + ++++fl  +++l++  l +lP+  lla++
  EFC38735.1 469 IQRTSTGVLRGASSQFLTMILNLIAYYLFSLPVSSLLAFV 508
                 4455555555555555555666777777777777766665 PP

  == domain 4  score: 14.5 bits;  conditional E-value: 4.8e-06
     MscS_TM 230 ilslllllllllvyalalRwllvarRRlayerakekRaaalaqrakeeeeeeekkesaeveepe 293
                 ++s+++l++++++ +++ R   v++ R+a era     ++  +++k+e+e++++++++ +ee+e
  EFC38735.1 520 LTSCMVLMAVIVLIYIIFRIDWVKEARIAHERAN----KIIVKTEKSEQETNSNTSNT-QEEEE 578
                 589*******************************....33333344444444333322.34444 PP

>> MAP17  Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   1.1       6.2   1.6e+04      31      46 ..     184     200 ..     167     204 .. 0.46
   2 ?   13.0   0.1   3.4e-05     0.088      31      92 ..     517     578 ..     487     583 .. 0.73

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 6.2
       MAP17  31 Wl.vGliAvvgFLflvf 46 
                 W+ +  i +  FL+ v+
  EFC38735.1 184 WMmRSFITLILFLLPVM 200
                 32133444444554444 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 3.4e-05
       MAP17  31 WlvGliAvvgFLflvfvlllvnrv.Wcskaraedeeeetfrmeankeedvslskeekkeeeke 92 
                 Wl Gl+   + + ++++++++ r+ W ++ar  +e +++  ++++k+e+ ++s++++++ee+e
  EFC38735.1 517 WL-GLTSCMVLMAVIVLIYIIFRIdWVKEARIAHERANKIIVKTEKSEQETNSNTSNTQEEEE 578
                 65.7888777777777777777777***********999988888888777777776653333 PP

>> Vpu  Vpu protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   1.4    0.0003      0.77       9      62 ..     518     571 ..     509     580 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.0003
         Vpu   9 lialivaliiaivvWtivyreykkikkqkeierlikrireraedSgnESdGeee 62 
                 l++    +++a++v  +++ +    k+ +  ++++++i+ + e+S++E + ++ 
  EFC38735.1 518 LGLTSCMVLMAVIVLIYIIFRIDWVKEARIAHERANKIIVKTEKSEQETNSNTS 571
                 344444455566666666666666778888899*************99887654 PP

>> AlaE  L-alanine exporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       4.1     1e+04      80      99 ..     185     204 ..     165     211 .. 0.62
   2 ?   -0.4   0.0      0.43   1.1e+03      19      40 ..     308     328 ..     291     330 .. 0.71
   3 ?   11.5   2.1   8.9e-05      0.23      70     135 ..     477     543 ..     415     546 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.1
        AlaE  80 nlaDllayvsfqsPvYaail 99 
                 ++   ++++ f  Pv ++++
  EFC38735.1 185 MMRSFITLILFLLPVMVVLF 204
                 45556677777777766554 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.43
        AlaE  19 fcfivgmlieilisGmsfeqsl 40 
                 f      + eili  m ++++ 
  EFC38735.1 308 F-HHRENIREILIGAMKWDEVF 328
                 3.3456789*********9985 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 8.9e-05
        AlaE  70 rlspskrlaknlaDllayvsfqsPvYaaillavGasleqivtavasnavvslvlgvayGlf.leyvR 135
                   ++s+++ +++ +l+ay  f  Pv +++ +++  +l ++  + +s +v++ v+  +y +f +++v+
  EFC38735.1 477 LRGASSQFLTMILNLIAYYLFSLPVSSLLAFVAKLELLGLWLGLTSCMVLMAVIVLIYIIFrIDWVK 543
                 4466677999************************************************998677776 PP

>> Adeno_E3B  Adenovirus E3B protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.7    0.0052        13      10      40 ..     179     209 ..     175     215 .. 0.87
   2 ?    5.3   0.5    0.0093        24      24      51 ..     523     551 ..     507     555 .. 0.71

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0052
   Adeno_E3B  10 ppftvyllygfvtlilicslvtvviafiqfi 40 
                 p   v+++  f+tlil    v vv+ f++ i
  EFC38735.1 179 PLVGVWMMRSFITLILFLLPVMVVLFFLESI 209
                 556799******************9998765 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0093
   Adeno_E3B  24 ilicslvtvviafiqfidwvc.vriaylr 51 
                  ++   v v+i +i  idwv   ria+ r
  EFC38735.1 523 CMVLMAVIVLIYIIFRIDWVKeARIAHER 551
                 3444456677777778***9647888766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (584 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1209  (0.0674327); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.53
# Mc/sec: 3327.58
//
Query:       EFC38736.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-15   56.9  13.7    8.6e-08   32.6   0.8    6.2  7  Sel1      Sel1 repeat
  ------ inclusion threshold ------
      0.038   13.8   1.6       0.39   10.5   0.2    2.8  2  LRR_8     Leucine rich repeat
       0.16   12.3   5.4         11    6.6   0.0    5.0  4  TPR_8     Tetratricopeptide repeat
       0.19   12.2   4.5        0.2   12.1   0.4    2.9  2  LRR_4     Leucine Rich repeats (2 copies)
       0.31   10.8   4.6        3.6    7.4   0.3    4.0  4  TPR_11    TPR repeat
        0.8    9.6   5.1         15    5.6   0.2    4.0  3  TPR_1     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.6      0.93   2.8e+03       1      11 [.     253     263 ..     253     267 .. 0.76
   2 ?    1.6   0.0      0.17   5.2e+02      26      38 .]     290     302 ..     283     302 .. 0.86
   3 !   32.6   0.8   2.9e-11   8.6e-08       3      37 ..     305     337 ..     303     338 .. 0.89
   4 !   21.8   0.0   7.3e-08   0.00022       1      38 []     339     374 ..     339     374 .. 0.96
   5 ?   -4.0   0.0         6   1.8e+04       7      17 ..     381     389 ..     378     396 .. 0.70
   6 ?    3.7   0.1     0.037   1.1e+02       6      38 .]     425     456 ..     423     456 .. 0.76
   7 ?    0.1   0.0       0.5   1.5e+03      21      38 .]     471     488 ..     463     488 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.93
        Sel1   1 aeAmyrLGmfy 11 
                 +eA+y  Gm+ 
  EFC38736.1 253 PEAYYFAGMLF 263
                 79******654 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.17
        Sel1  26 AiewyekAAeqGd 38 
                 A+ w+e+ Ae+++
  EFC38736.1 290 ARVWFELGAEKNN 302
                 888*******986 PP

  == domain 3  score: 32.6 bits;  conditional E-value: 2.9e-11
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 +myrLG  ++y++G+  +k  ekA+ewy kAA+++
  EFC38736.1 305 CMYRLG--EFYEYGKSFEKSDEKALEWYNKAADLN 337
                 7*****..666****98999*************97 PP

  == domain 4  score: 21.8 bits;  conditional E-value: 7.3e-08
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 ++A++r++  ++++ G  +p D  k++e+++kAA++G+
  EFC38736.1 339 PDALMRVA--EFHFLGIATPVDDLKGLEYLKKAADNGN 374
                 689*****..999****9******************97 PP

  == domain 5  score: -4.0 bits;  conditional E-value: 6
        Sel1   7 LGmfylylnGl 17 
                 L+ fy  ++G+
  EFC38736.1 381 LAGFY--EDGK 389
                 66566..8886 PP

  == domain 6  score: 3.7 bits;  conditional E-value: 0.037
        Sel1   6 rLGmfylylnGl.gvpkDpekAiewyekAAeqGd 38 
                 r G  +l+++ +  + +D e A+ +++++ ++G+
  EFC38736.1 425 RAG--CLHMFEQeWEQADMEYAFSCLQRSSKLGN 456
                 666..445555534788***************97 PP

  == domain 7  score: 0.1 bits;  conditional E-value: 0.5
        Sel1  21 kDpekAiewyekAAeqGd 38 
                 ++ e+A+ ++  A +qG+
  EFC38736.1 471 QNGELAYSFFLIAKKQGH 488
                 68899************8 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.11   3.4e+02      19      39 ..      71      93 ..      68     113 .. 0.64
   2 ?   10.5   0.2   0.00013      0.39      24      59 ..     127     165 ..     123     165 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.11
                TSSTT-TT--EE..E--SS---G CS
       LRR_8 19 eaFkglsnLkvL..dLsnNlltt 39
                + Fkgl+ L++L  +L + + + 
  EFC38736.1 71 SNFKGLKILQILggNLDESSVRK 93
                68999999999966666666666 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00013
                 -TT--EEE--SS---G.GGGGGG..TT--S-.EEE--SS CS
       LRR_8  24 lsnLkvLdLsnNlltt.lspgaf..sgLpsLrsLdLsgN 59 
                 +++Lk Ld+s+N++t    ++++  + LpsL++L ++ N
  EFC38736.1 127 WNQLKLLDISRNKITKkALENCMkeMKLPSLEYLFVDEN 165
                 789************942245553336899999988876 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       1.1   3.1e+03       3      20 ..     203     220 ..     201     224 .. 0.81
   2 ?   -2.3   0.0       2.4   7.2e+03       2      11 ..     254     263 ..     253     266 .. 0.79
   3 ?    3.6   0.5     0.033        97      16      31 ..     322     337 ..     305     340 .. 0.85
   4 ?    6.6   0.0    0.0036        11      16      34 .]     401     419 ..     401     419 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.1
                 HHHHHHHHHHHTT-HHHH CS
       TPR_8   3 ayynlgsiylklgdyeeA 20 
                 ++++++++y+k +  e++
  EFC38736.1 203 LLLKKALVYSKEKTPEKS 220
                 678999***999988876 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2.4
                 CHHHHHHHHH CS
       TPR_8   2 eayynlgsiy 11 
                 eayy  g++ 
  EFC38736.1 254 EAYYFAGMLF 263
                 89***99886 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.033
                 -HHHHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekaleld 31 
                   e+A e+y+ka +l+
  EFC38736.1 322 SDEKALEWYNKAADLN 337
                 568999*****99987 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0036
                 -HHHHHHHHHHHHHHHHH. CS
       TPR_8  16 dyeeAkeyyekaleldpdn 34 
                 +++ A ++y k+l++dp+n
  EFC38736.1 401 NLDLADQTYSKYLSIDPNN 419
                 5799*************97 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.2      0.43   1.3e+03       4      33 ..      50      85 ..      49     107 .. 0.69
   2 ?   12.1   0.4   6.7e-05       0.2       2      33 ..     129     165 ..     128     172 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.43
                -EEE--SS---E-S-...HH..H-TT--EEE-..-S CS
       LRR_4  4 evLdLsnNqltdipl...le..klpnLkeLdL.sgN 33
                + + L n+++ + +    +e  +++ Lk L +  gN
  EFC38736.1 50 KRIFLLNTKVGSEEVdaiCEnsNFKGLKILQIlGGN 85
                556666677776666444224459999999873445 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 6.7e-05
                 S--EEE--SS---E-S-HH......H-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdiplle......klpnLkeLdLsgN 33 
                 +L+ Ld+s N++t+   le      klp+L++L + +N
  EFC38736.1 129 QLKLLDISRNKITKK-ALEncmkemKLPSLEYLFVDEN 165
                 5999*********63.4556999988*******99777 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.7     5e+03       4      19 ..      29      44 ..      28      44 .. 0.87
   2 ?   -0.4   0.2      0.32   9.5e+02      27      40 ..     252     265 ..     250     266 .. 0.88
   3 ?    7.4   0.3    0.0012       3.6      11      24 ..     324     337 ..     321     342 .. 0.88
   4 ?    1.6   0.0     0.073   2.2e+02      13      35 ..     405     427 ..     401     431 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.7
      TPR_11  4 yyeqGkyeeAieaYkk 19
                ++e+G+   A e+++k
  EFC38736.1 29 LFELGESSTASEELQK 44
                7999999999999986 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.32
      TPR_11  27 naeayynLGlayyk 40 
                 ++eayy  G ++yk
  EFC38736.1 252 YPEAYYFAGMLFYK 265
                 8*****99988887 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0012
      TPR_11  11 eeAieaYkkAlkld 24 
                 e+A+e+Y+kA +l+
  EFC38736.1 324 EKALEWYNKAADLN 337
                 99********9997 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.073
      TPR_11  13 AieaYkkAlkldPdnaeayynLG 35 
                 A + Y+k l +dP+n  +++  G
  EFC38736.1 405 ADQTYSKYLSIDPNNSGILFRAG 427
                 55789999*******88877666 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1       3.4     1e+04       5      18 ..     307     320 ..     306     322 .. 0.71
   2 ?    5.6   0.2    0.0049        15      18      31 ..     324     337 ..     323     337 .. 0.92
   3 ?    3.7   0.1      0.02        60      17      34 .]     402     419 ..     401     419 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 3.4
                 HHHHHHHHHTT-HH CS
       TPR_1   5 ynlGnayfklgkyd 18 
                 y+lG  y + + ++
  EFC38736.1 307 YRLGEFYEYGKSFE 320
                 88888887766665 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0049
                 HHHHHHHHHHHHHS CS
       TPR_1  18 deAleyyekALeln 31 
                 ++Ale y+kA  ln
  EFC38736.1 324 EKALEWYNKAADLN 337
                 79********9987 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.02
                 HHHHHHHHHHHHHHSTTH CS
       TPR_1  17 ydeAleyyekALelnPnn 34 
                 +d A + y+k L+++Pnn
  EFC38736.1 402 LDLADQTYSKYLSIDPNN 419
                 6788899**********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       578  (0.0322383); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.28s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 3056.85
//
Query:       EFC38737.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-08   35.2   0.0    4.7e-08   33.6   0.0    1.8  1  SET              SET domain
    4.9e-07   30.5   0.2    9.2e-07   29.6   0.2    1.5  1  Rubis-subs-bind  Rubisco LSMT substrate-binding
  ------ inclusion threshold ------
       0.23   11.9   2.5       0.35   11.3   0.0    2.4  3  Staphylokinase   Staphylokinase/Streptokinase family


Domain annotation for each model (and alignments):
>> SET  SET domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.6   0.0   7.9e-12   4.7e-08       1     169 []      70     306 ..      70     306 .. 0.69

  Alignments for each domain:
  == domain 1  score: 33.6 bits;  conditional E-value: 7.9e-12
                 SCEEEESSXBXTTXEEEEEEECCEECHHHHHHHHHH....................................................HTEEEEEXGGX CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....................................................xxxxxxxxxxx RF
         SET   1 GrGvfAtedIpkgeficeypeeiiltkdeadksele....................................................aylfslpeapk 47 
                 G  ++At+dI+++++++++ +e++l + +  ++  +                                                    +y+ slp+ + 
  EFC38737.1  70 GKALVATKDIKQNTILFKLKQETLLDSKFIFEKLFKhenaksldtlkrlqegdlsifnamvlmivylfnlaqssnpemkfdadavkftPYIGSLPRPFR 168
                 6679*************988555555555555555555556688899******************9999999999999999999999999999998844 PP

                 X....GGSX...HHHHHHHTTSSHHHHHHHHHHHH...HHHHHHTHHHHHHHXTTTSXXXHCCCCC...HCCCHEEEETEEEEEECCC........... CS
                 x....xxxx...xxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxx........... RF
         SET  48 n....laft...kelakasastllqklakdqkqae...kedtdaalkasskaesdlnaskpeagaf...saiagysidaralksgnga........... 122
                 +    +af    +el+ +++stll ++  + +      ++  +  l++  + e  +n+s  + g f      +++            +           
  EFC38737.1 169 DegpkVAFLfggEELTLLKGSTLLPSALTRRQSIAnsfQKIVNPLLNDLTVLEPIRNTSSITLGLFehfVSLSWSR-----------Ihsiydyriktd 256
                 455775554579***********99987665443300033333344444444444443333333331212222222...........133333334556 PP

                 ....GTTGGGCEEXS.SSSEEEEEEEETTSSEEEEEESSXBXTTEEEEEXTT CS
                 ....xxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         SET 123 ....gplarflNHsC.dpNcnltvqnvlrgprvavfAtrdIkkGeEltidYg 169
                     +pl++++N s    N+  +++  ++ +++++ +++++k+G +l++ Yg
  EFC38737.1 257 rscfVPLGDIINFSKtGANVISYTD--KKTNELIFKTSKRVKAGNQLFVKYG 306
                 66779*******9852346644444..59**********************8 PP

>> Rubis-subs-bind  Rubisco LSMT substrate-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6   0.2   1.5e-10   9.2e-07       6     129 .]     358     501 ..     341     501 .. 0.81

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 1.5e-10
  Rubis-subs-bind   6 aeeKlqlLerhgl......pstqefplkle................egipeeLlaylrvllasekdakeleelaskeedsg........lasep 69 
                       +++ +lL+   l      +         +                e  +++ +a +r+l+++  + k+l  +a++    +           +p
       EFC38737.1 358 NNQRVRLLSMTSLdeyhltQ---------TlyynddsfnlvehtlsEIFDPNIIAIMRILSCDSVEIKALSDIANSLAPLDqkrdmiakILINP 442
                      56677777744444443330.........23333445555555777999*************9999999999999966655889****9888** PP

  Rubis-subs-bind  70 lsddnEaaalrllldrckalLsaypttleeDeellkdadaavtnrerlavqlrvgEkrIL 129
                      +sd+nE+ +++++  ++k++L++    ++e e +l +  + vt  ++ av++  +Ek+IL
       EFC38737.1 443 ISDRNEKIVIETIRGLIKQRLDNIIEMIQENESILGKRLP-VTMSQKCAVRYIQSEKKIL 501
                      ******************************8888877655.6789**************9 PP

>> Staphylokinase  Staphylokinase/Streptokinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       1.6   9.7e+03      31      47 ..      79      95 ..      59     114 .. 0.60
   2 ?   -1.1   0.0       0.4   2.4e+03      81      99 ..     276     294 ..     263     320 .. 0.55
   3 ?   11.3   0.0   5.9e-05      0.35      32      77 ..     349     394 ..     321     397 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.6
  Staphylokinase 31 ikngkigekltseeLlk 47
                    ik+++i  kl+ e Ll+
      EFC38737.1 79 IKQNTILFKLKQETLLD 95
                    44455555555555553 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.4
  Staphylokinase  81 eftyhdknrkvvfakdpKr 99 
                      ++y dk    ++ k  Kr
      EFC38737.1 276 VISYTDKKTNELIFKTSKR 294
                     3344444444443322222 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 5.9e-05
  Staphylokinase  32 kngkigekltseeLlkaieeqLdardpaytiyqnddsfeivdfdsd 77 
                        ++  kl+ +  +  +   Ld+ +  +t+y nddsf++v+++++
      EFC38737.1 349 RMSTVDKKLNNQRVRLLSMTSLDEYHLTQTLYYNDDSFNLVEHTLS 394
                     55678899999********************************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       962  (0.0536561); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 3017.56
//
Query:       EFC38738.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.6e-21   75.2  16.8    6.8e-05   22.7   0.4    6.1  6  NHL           NHL repeat
    1.6e-15   57.1  13.3    3.9e-08   32.8   0.6    3.4  4  DUF5128       6-bladed beta-propeller
    4.7e-05   23.5   0.1        1.7    8.9   0.0    3.6  4  Arylesterase  Arylesterase
      7e-05   22.2   0.3      0.051   12.8   0.0    2.8  3  TolB_like     TolB-like 6-blade propeller-like
    0.00026   20.8   0.8     0.0092   15.9   0.1    3.0  3  DUF4934       Domain of unknown function (DUF4934)
     0.0036   16.9   0.2        8.7    5.8   0.0    3.5  4  SGL           SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
        0.1   12.7   0.0       0.19   11.8   0.0    1.4  1  DUF87         Helicase HerA, central domain
       0.15   12.2   0.0        3.5    7.8   0.0    2.6  3  SH3_7         SH3 domain of SH3b2 type


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.4   3.1e-08   6.8e-05       1      28 []      59      87 ..      59      87 .. 0.96
   2 !    8.9   0.1   0.00074       1.6       1      27 [.     143     172 ..     143     173 .. 0.81
   3 ?    4.0   0.1     0.025        56      11      23 ..     166     178 ..     164     183 .. 0.77
   4 !   20.4   0.7   1.6e-07   0.00036       7      27 ..     199     219 ..     198     220 .. 0.94
   5 !   15.5   0.1   5.6e-06     0.013       1      28 []     240     268 ..     240     268 .. 0.96
   6 !   14.8   0.0   9.5e-06     0.021       3      27 ..     283     308 ..     282     309 .. 0.94

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 3.1e-08
                BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL  1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28
                f++P + +vd ++  i+V+Ds+n+ +qvF
  EFC38738.1 59 FSNPYDMCVDnNQELIFVCDSGNNAIQVF 87
                78999***********************9 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00074
                 BSSEEEEEEE.TT..TEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.sn..GdiyVaDsenhrvqv 27 
                 fn P+G+a+d ++   +iy +D  n+r+ v
  EFC38738.1 143 FNLPSGIAIDfNSkeRNIYLCDQANNRILV 172
                 88999999977752278**********987 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.025
                 TTTEEEEEECCCT CS
         NHL  11 snGdiyVaDsenh 23 
                  n++i+V Ds+ +
  EFC38738.1 166 ANNRILVLDSNGN 178
                 589******7755 PP

  == domain 4  score: 20.4 bits;  conditional E-value: 1.6e-07
                 EEEETTTEEEEEECCCTEEEE CS
         NHL   7 vavdsnGdiyVaDsenhrvqv 27 
                 ++  ++++++++D++nhrvq+
  EFC38738.1 199 ICFGNDDNLIITDRYNHRVQI 219
                 7999****************8 PP

  == domain 5  score: 15.5 bits;  conditional E-value: 5.6e-06
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 fn+P +v+v   +G+iyV+Ds n r+q+F
  EFC38738.1 240 FNEPCSVCVEkRTGNIYVSDSFNDRIQIF 268
                 899999**********************9 PP

  == domain 6  score: 14.8 bits;  conditional E-value: 9.5e-06
                 SEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavd.snGdiyVaDsenhrvqv 27 
                 yP G++++  nGd++V++ ++ rv++
  EFC38738.1 283 YPLGISLNdRNGDLLVTEWRSGRVVI 308
                 9**********************987 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1       2.4   5.4e+03     155     181 ..      12      38 ..       9      47 .. 0.67
   2 !   12.3   0.4   3.1e-05      0.07     101     141 ..      62     102 ..      58     131 .. 0.83
   3 !   21.4   0.1   5.2e-08   0.00012      63     104 ..     158     199 ..     138     205 .. 0.90
   4 !   32.8   0.6   1.7e-11   3.9e-08      57     136 ..     198     277 ..     195     289 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.4
     DUF5128 155 ifdssriedekrskfnlvvtdeegnei 181
                 ++d +++++e++ + + vv++e+g+e+
  EFC38738.1  12 FYDDDDLQEEEELDWQTVVEEEDGKEV 38 
                 567777777777777777777776655 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 3.1e-05
     DUF5128 101 indfiidksnesIyildfmknkiltYdLegykfieekkldl 141
                   d  +d+++e I++ d+ +n i +++L++y+++++++  +
  EFC38738.1  62 PYDMCVDNNQELIFVCDSGNNAIQVFELNTYEWKYKIDCGA 102
                 56899***************************999887654 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 5.2e-08
     DUF5128  63 krifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindf 104
                   i++ D+a+n+++v d +G++vr+ g+ G+G  E++q  ++
  EFC38738.1 158 RNIYLCDQANNRILVLDSNGNYVREFGKHGSGNLEFIQSRNI 199
                 579**********************************98776 PP

  == domain 4  score: 32.8 bits;  conditional E-value: 1.7e-11
     DUF5128  57 kikvvd.krifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknkiltYdLegykfiee 136
                 +i++ + + ++++D+++ ++ + +k+Gkf++  g++G   gE+ +  +  ++k   +Iy+ d+++++i ++  eg +++e 
  EFC38738.1 198 NICFGNdDNLIITDRYNHRVQIISKEGKFIKSFGKRGRENGEFNEPCSVCVEKRTGNIYVSDSFNDRIQIFTSEG-EYLES 277
                 677766599**************************************************************9998.99875 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0   0.00076       1.7      34      82 ..      40      88 ..      35      91 .. 0.90
   2 !    8.9   0.0   0.00076       1.7      49      82 ..     139     174 ..     121     178 .. 0.80
   3 ?   -0.3   0.0      0.55   1.2e+03      55      81 ..     242     268 ..     237     273 .. 0.76
   4 ?    0.1   0.0      0.43   9.7e+02      39      74 ..     267     302 ..     262     312 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00076
  Arylesterase 34 awtavvYyspsevkvvasglssanGInidadkkyiyvadilresihvmk 82
                  + t+ v y  +++  v  ++s +  + +d ++  i+v d+ ++ i v++
    EFC38738.1 40 INTNNVRYCYKKILGVNRRFSNPYDMCVDNNQELIFVCDSGNNAIQVFE 88
                  678888899999*******************************999887 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00076
  Arylesterase  49 vasglssanGInid..adkkyiyvadilresihvmk 82 
                      g++ + GI id  ++++ iy+ d  ++ i v++
    EFC38738.1 139 TTGGFNLPSGIAIDfnSKERNIYLCDQANNRILVLD 174
                   56789******9984467889**********99886 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.55
  Arylesterase  55 sanGInidadkkyiyvadilresihvm 81 
                    +  + ++     iyv+d+ ++ i ++
    EFC38738.1 242 EPCSVCVEKRTGNIYVSDSFNDRIQIF 268
                   5666677777788*****999988665 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.43
  Arylesterase  39 vYyspsevkvvasglssanGInidadkkyiyvadil 74 
                   ++ s +e  + + g++ + GI ++  +  + v++  
    EFC38738.1 267 IFTSEGEYLESVTGVDYPLGISLNDRNGDLLVTEWR 302
                   5667788889999********999888777777765 PP

>> TolB_like  TolB-like 6-blade propeller-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.2   2.6e+03     264     273 ..      80      89 ..      56     100 .. 0.55
   2 !    9.2   0.0   0.00028      0.63      51      93 ..     178     221 ..     156     225 .. 0.84
   3 !   12.8   0.0   2.3e-05     0.051      28      96 ..     204     272 ..     203     330 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.2
   TolB_like 264 lgkeiyVFdl 273
                 +++ i+VF+l
  EFC38738.1  80 GNNAIQVFEL 89 
                 2333444444 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00028
   TolB_like  51 qfvssfakrGrgpeemlsaeefri.skdslwvldkskltaakii 93 
                 ++v++f+k+G g  e++   ++++ ++d+l + d+ + +++ i 
  EFC38738.1 178 NYVREFGKHGSGNLEFIQSRNICFgNDDNLIITDRYNHRVQIIS 221
                 79********************7636777788899877766655 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 2.3e-05
   TolB_like  28 ddilvilDlhgddffyaysypelqfvssfakrGrgpeemlsaeefriskd..slwvldkskltaakiifnk 96 
                 dd l+i D  + + +   s +e +f++sf+krGr  +e+ ++ +++++k   +++v d+ + +++ + ++ 
  EFC38738.1 204 DDNLIITDRYNHR-VQIIS-KEGKFIKSFGKRGRENGEFNEPCSVCVEKRtgNIYVSDSFNDRIQIFTSEG 272
                 6666777666655.44444.6889*********************99985337999999977777776655 PP

>> DUF4934  Domain of unknown function (DUF4934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.17   3.8e+02      75     100 ..     110     135 ..      99     137 .. 0.85
   2 ?   -0.5   0.0      0.52   1.2e+03      78     101 ..     156     180 ..     147     188 .. 0.64
   3 !   15.9   0.1   4.1e-06    0.0092      28     101 ..     198     275 ..     192     276 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.17
     DUF4934  75 lndatgllyfsrkpdklvkydakGef 100
                 +n+++ ++ f  ++++l ky + G++
  EFC38738.1 110 FNPEDSTILFGSNDNTLYKYSVFGKL 135
                 588999999999********998875 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.52
     DUF4934  78 atgllyfs.rkpdklvkydakGefl 101
                 ++  +y+  ++++++ + d +G+++
  EFC38738.1 156 KERNIYLCdQANNRILVLDSNGNYV 180
                 4455554414566777777777775 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 4.1e-06
     DUF4934  28 kikll.kdkivvss..kkqCllfdketGkflasvGhiGedPegysev.agwlndatgllyfsrk.pdklvkydakGefl 101
                 +i++  +d+++++   +++ ++ +k +Gkf++s G +G +   ++e  +  ++++tg +y s + +d+++++  +Ge+l
  EFC38738.1 198 NICFGnDDNLIITDryNHRVQIISK-EGKFIKSFGKRGRENGEFNEPcSVCVEKRTGNIYVSDSfNDRIQIFTSEGEYL 275
                 5665415667777664556666665.6***********99999999835678999*****987537899*******996 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0     0.089     2e+02     189     213 ..      65      90 ..      31     119 .. 0.69
   2 !    5.8   0.0    0.0039       8.7     132     212 ..     142     222 ..     109     231 .. 0.54
   3 !    5.1   0.0    0.0065        15     184     221 ..     241     279 ..     230     299 .. 0.87
   4 ?   -1.3   0.0       0.6   1.3e+03     191     208 ..     290     307 ..     256     312 .. 0.59

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.089
         SGL 189 lavDa.eGnvwvAvwgggkvvrfdpd 213
                 ++vD+ +  ++v+  g++ +++f+ +
  EFC38738.1  65 MCVDNnQELIFVCDSGNNAIQVFELN 90 
                 66666555566666666666666554 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0039
         SGL 132 dltipNGla..wspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge...gepDGlavDaeGnvwvAvwgggkvvrfdp 212
                 +++ p G+a  +++ ++ +Yl+D ++++i + d +  g+     r f +   g+    +   ++  +++n++++   +++v+ +++
  EFC38738.1 142 GFNLPSGIAidFNSKERNIYLCDQANNRILVLDSN--GN---YVREFGKHGSGNlefIQSRNICFGNDDNLIITDRYNHRVQIISK 222
                 55555554422677777777777777777776653..22...22333222333323311223444444444444444445555554 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.0065
         SGL 184 gepDGlavDa.eGnvwvAvwgggkvvrfdpdGklieeik 221
                 +ep +++v++ +Gn++v    +++++ f+ +G+ +e ++
  EFC38738.1 241 NEPCSVCVEKrTGNIYVSDSFNDRIQIFTSEGEYLESVT 279
                 45888999999**********************999875 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.6
         SGL 191 vDaeGnvwvAvwgggkvv 208
                  D +G + v+ w++g+vv
  EFC38738.1 290 NDRNGDLLVTEWRSGRVV 307
                 255777777777777776 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   8.7e-05      0.19      50      92 ..     165     209 ..     158     219 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8.7e-05
       DUF87  50 kkgatililDpHGEYgkalekllsekvkvitpspsa..kdkelki 92 
                 + + +il+lD +G Y++ + k++s++++ i+ ++ +  +d +l i
  EFC38738.1 165 QANNRILVLDSNGNYVREFGKHGSGNLEFIQSRNICfgNDDNLII 209
                 66789*************************998777776665554 PP

>> SH3_7  SH3 domain of SH3b2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       7.5   1.7e+04      24      32 ..     172     180 ..     168     180 .. 0.79
   2 ?    1.0   0.0      0.22   4.9e+02      19      33 ..     262     276 ..     262     278 .. 0.89
   3 ?    7.8   0.0    0.0016       3.5       5      24 ..     298     315 ..     297     321 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 7.5
                 EE-TTS-EE CS
       SH3_7  24 lyDatgqyl 32 
                 + D++g y+
  EFC38738.1 172 VLDSNGNYV 180
                 679999996 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.22
                 STTEEEE-TTS-EEE CS
       SH3_7  19 rdnvplyDatgqylf 33 
                 +d++++++++g+yl 
  EFC38738.1 262 NDRIQIFTSEGEYLE 276
                 699**********85 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0016
                 HHHHHSS.-EEEE-STTEEE CS
       SH3_7   5 vttwrsaqrfaviirdnvpl 24 
                 vt+wrs+  ++vi++dn ++
  EFC38738.1 298 VTEWRSG--RVVILKDNFFI 315
                 89*****..********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       520  (0.0290033); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2037.83
//
Query:       EFC38739.1  [L=489]
Description: catalase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   2.3e-196  652.4   0.3   2.8e-196  652.1   0.3    1.1  1  Catalase      Catalase
    8.3e-22   77.2   0.1    1.9e-21   76.0   0.1    1.6  1  Catalase-rel  Catalase-related immune-responsive


Domain annotation for each model (and alignments):
>> Catalase  Catalase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  652.1   0.3  3.1e-200  2.8e-196       1     382 [.      14     396 ..      14     397 .. 0.98

  Alignments for each domain:
  == domain 1  score: 652.1 bits;  conditional E-value: 3.1e-200
                 B-TTS-B-S-SSS-EEESTTS-BBTT-HHHHHHHHHHHT------SS--SEEEEEEEEEESS--TTT---GGGSSTT-EEEEEEEEE-SS--TT--SSS CS
    Catalase   1 ttseGapvsdnqnsltagerGplllqdvhlieklahfdreripeRvvhAkGagahgeFevtkdisdltkakllskvgkktpvlvRfStvagekgsadta 99 
                 t + G+pv+dn+nsltag++Gp+llqd++li klahfdreripeRvvhAkGagahg+Fevt+di+++tka++l++vgk+tpv++RfStv+gekgsad+ 
  EFC38739.1  14 TDEFGHPVADNNNSLTAGNNGPILLQDTYLISKLAHFDRERIPERVVHAKGAGAHGYFEVTHDITKFTKAAFLNRVGKRTPVFARFSTVGGEKGSADSD 112
                 6788*********************************************************************************************** PP

                 SS--EEEEEEEETTEEEEEEEESSSS-S-S-GGGHHHHHHHHSB-TTT-SB-HHHHHHHHHT-GGGHHHHHHHHSGGGSBS-GGGS-EE--S-EEEE-T CS
    Catalase 100 RdvrGfavkfyTeeGnwDlvgnntpvFfirDpikfpdlihsqkrepqtnlkdaamfwdflslnpeslhqvlilfsdrgipksyrhmngygvhtfklvnk 198
                 Rd+rGfavkfyTeeGn+D+vgnntpvFfirD+ikfpd+ih+qkr+pq+nlkd+++fwdflsl+pes+hq+++lfsdrg+p syrhmngy++htfklvn+
  EFC38739.1 113 RDPRGFAVKFYTEEGNYDFVGNNTPVFFIRDTIKFPDFIHTQKRNPQSNLKDPDAFWDFLSLTPESVHQLTVLFSDRGTPFSYRHMNGYSGHTFKLVNS 211
                 *************************************************************************************************** PP

                 T--EEEEEEEEEETT---B--HHHHHHHHHH-TTHHHHHHHHHHHTT---EEEEEEEEEEHHHHTTTHHHHT-TT----TTTS--EEEEEEEEEE--S- CS
    Catalase 199 egevvyvkfhfktkqgvknltaeeaeklagedpdyatrdLyeaiekgeypewelyvqvmteeeaeklrfnilDlTkvwpekevplrevGkltLnrnpen 297
                 +ge+++ k+hfkt+qg+knlt eea++lagedpd+atrdL+++i++g+ p w++y q+m+ ++a k++++++D+Tkvw +k++pl++vG+++Lnrnp+n
  EFC38739.1 212 QGEAFWAKIHFKTEQGIKNLTVEEATRLAGEDPDHATRDLFNSIKQGSSPAWKVYFQIMPVDDAAKYKVDVFDITKVWAHKDYPLIPVGRMVLNRNPNN 310
                 *************************************************************************************************** PP

                 HHHHTTT----TT---TTEE--S-HHHHHHHHHHHHHHHHHT-TTGGGSGGG--.-..---S----TT-.....S-S---SS-S-T CS
    Catalase 298 yFaevEqvafspsnlvpGiepseDklLqgRlfsYadtqryRlGvnyqqlpvNrp.kakvanyqrdGamrveankgkepnYepnsle 382
                 yFae+Eq afspsnlvpGieps Dk+LqgRlfsY+dt+r+RlG+ny q+p+N+p kak++ + rdG+m+v+ n g++pnYepn+++
  EFC38739.1 311 YFAETEQSAFSPSNLVPGIEPSLDKMLQGRLFSYPDTHRHRLGANYAQIPINAPlKAKLNCQFRDGSMTVNGNGGSAPNYEPNTFG 396
                 ******************************************************766777555********************985 PP

>> Catalase-rel  Catalase-related immune-responsive
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.0   0.1   2.1e-25   1.9e-21       4      65 .]     423     484 ..     420     484 .. 0.96

  Alignments for each domain:
  == domain 1  score: 76.0 bits;  conditional E-value: 2.1e-25
                   G--SSHHHHHHHH.HS-HHHHHHHHHHHHHHHTTSS-HHHHHHHHHHHHHH-HHHHHHHHHHH CS
  Catalase-rel   4 fddhfsQagllyr.smseeekerlvnniafelskvedeeiqerqlehfakvDpdlgqrVaeal 65 
                    +d++ Qag+lyr +m+e ++ rlv+nia +l++++ +eiq rql++f+k+D+d+g+r+ae l
    EFC38739.1 423 PNDDYVQAGTLYReVMTEYDRSRLVHNIALHLKNAK-KEIQLRQLQIFYKADKDYGRRIAELL 484
                   58*********************************9.***********************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       385  (0.0214736); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 2802.00
//
Query:       EFC38740.1  [L=330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-06   28.0   4.2     0.0016   18.3   0.1    2.5  2  PHD       PHD-finger
  ------ inclusion threshold ------
       0.13   12.5   0.3       0.39   11.0   0.3    1.8  1  E7        E7 protein, Early protein
        1.1    7.9   7.9          2    7.1   7.9    1.4  1  Raftlin   Raftlin
        4.2    7.1   5.5         23    4.7   0.1    2.7  3  zf_UBZ    Ubiquitin-Binding Zinc Finger


Domain annotation for each model (and alignments):
>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.7    0.0001      0.47       1      24 [.     225     246 ..     225     249 .. 0.90
   2 !   18.3   0.1   3.5e-07    0.0016      22      51 ..     260     288 ..     260     289 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.0001
                 SBTTTTSTTSTTSCEEEETTTSCE CS
         PHD   1 rCavCkkksdeeeelvqCdgCkrw 24 
                 +C  C++     + ++ Cd+C++ 
  EFC38740.1 225 YC-KCNR-PASYGWMIACDRCDKY 246
                 68.99*9.999**********986 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 3.5e-07
                 SCEEETTTSSSTHSHHSHHSSTBSSTTTHT CS
         PHD  22 krwfHqkClkppleseekpegewlCekCke 51 
                 +rwfH  Cl++++ +++   g ++C+ C++
  EFC38740.1 260 NRWFHGRCLGLKKYQANSI-GTYICPDCET 288
                 58**********9977776.5*******86 PP

>> E7  E7 protein, Early protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.3   8.6e-05      0.39      22      68 ..     206     251 ..     194     254 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 8.6e-05
                 ------XXXXXXXXXXXXXXXXXXXXEE.EEEEEEXTTTXXEEEEEE CS
          E7  22 ceeelesedeeeeeedeptlkdktprrpgYavevaCprCeqklrlvv 68 
                 + e +++++++  eed +tl  k +r  +Y    aC rC++ + +++
  EFC38740.1 206 SGEDSDDSENDSSEED-ETLYCKCNRPASYGWMIACDRCDKYVFFTI 251
                 5666666665555555.468889999999************998887 PP

>> Raftlin  Raftlin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   7.9   0.00045         2     173     285 ..     129     233 ..     113     250 .. 0.51

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00045
     Raftlin 173 nsssltsgaaeseeardekkkrsssedkvslenekpgalsgksseaga.eeeaeseegkkgegpaaeqlqlssaeeegsespskskkgeeelsktedkl 270
                 ns s   ++++++++ +++ ++ss+ed+ s+++e   ++s++ss++++   +++ +     ++ + ++ q  ++ ++++e +  s +ge+++ + +d++
  EFC38740.1 129 NSPS---NESTTTTTSSSTCNSSSPEDSGSNRKE--PTTSSSSSNTNSsTSSITDS----PNSSNKKRRQFINRANKKKEDKGDSDSGEDSDDSENDSS 218
                 2222...222222334555666667777776666..22222222222202222222....222223333333333334444444556666667777888 PP

     Raftlin 271 skklelfalFnkpks 285
                 +++  l++  n+p s
  EFC38740.1 219 EEDETLYCKCNRPAS 233
                 888888888887765 PP

>> zf_UBZ  Ubiquitin-Binding Zinc Finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       1.9   8.7e+03       7      14 ..     144     151 ..     143     152 .. 0.78
   2 ?    4.7   0.1    0.0051        23       3      12 ..     238     247 ..     237     248 .. 0.85
   3 ?    4.4   0.3    0.0064        29       2      10 ..     280     288 ..     279     289 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 1.9
      zf_UBZ   7 rCgkeipe 14 
                  C+++ pe
  EFC38740.1 144 TCNSSSPE 151
                 69999887 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0051
      zf_UBZ   3 ylCerCgkei 12 
                 + C+rC+k++
  EFC38740.1 238 IACDRCDKYV 247
                 67*****986 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.0064
      zf_UBZ   2 tylCerCgk 10 
                 ty+C++C +
  EFC38740.1 280 TYICPDCET 288
                 9******75 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2033  (0.113392); expected 358.6 (0.02)
Passed bias filter:                      668  (0.0372581); expected 358.6 (0.02)
Passed Vit filter:                       140  (0.00780858); expected 17.9 (0.001)
Passed Fwd filter:                        33  (0.00184059); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.87u 0.37s 00:00:01.24 Elapsed: 00:00:00.56
# Mc/sec: 1782.30
//
Query:       EFC38741.1  [L=357]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-14   53.9   2.1    2.8e-14   53.9   2.1    2.8  3  PRKCSH    Glucosidase II beta subunit-like protein
  ------ inclusion threshold ------
      0.012   16.1   1.1       0.08   13.4   1.1    2.4  1  CttA_N    Cellulose-binding protein CttA N-terminal domain
       0.14   12.3   0.3       0.14   12.3   0.3    1.9  2  DUF2845   Protein of unknown function (DUF2845)


Domain annotation for each model (and alignments):
>> PRKCSH  Glucosidase II beta subunit-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       2.7   1.6e+04      50      50 ..      76      76 ..      56      96 .. 0.53
   2 !   53.9   2.1   4.7e-18   2.8e-14       1      81 []     106     182 ..     106     182 .. 0.93
   3 ?   -2.8   3.9       2.3   1.4e+04      38      39 ..     302     303 ..     227     344 .. 0.58

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.7
                E CS
      PRKCSH 50 a 50
                 
  EFC38741.1 76 S 76
                1 PP

  == domain 2  score: 53.9 bits;  conditional E-value: 4.7e-18
                 X-EEEEEETTEEEEEETTTEEEEE-EETTEE-S--EEEEEE..EEEEEEE-------.....---S--EEEEEEEEE-SB- CS
      PRKCSH   1 gkCvsskegwwtYelCygkkvrQfhepekekgksevvLGrfnkeehsewaekneaksystedeekqsnryislkyenGtkC 81 
                 ++C+ ++ gww Ye+C++k vrQfh+ e++  ++e++LG     ++++ ++kn++  + + +e++  + yis  +e+Gt+C
  EFC38741.1 106 SNCYFRIAGWWLYEFCFNKFVRQFHQ-EQHTVTNEYFLGYS---KEQSPTNKNVKYFDINFNEQTPEESYISIPFEKGTPC 182
                 58************************.************55...8888888888888999********************* PP

  == domain 3  score: -2.8 bits;  conditional E-value: 2.3
                 EE CS
      PRKCSH  38 LG 39 
                 +G
  EFC38741.1 302 IG 303
                 33 PP

>> CttA_N  Cellulose-binding protein CttA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   1.1   1.3e-05      0.08       4      54 ..     120     171 ..     118     189 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.3e-05
      CttA_N   4 fYfseddreFnkaqlikviliidttkketeierkdv.ladinFngaTPkstY 54 
                 f f++  r+F+++q  ++      + ke+   +k+v   dinFn +TP++ Y
  EFC38741.1 120 FCFNKFVRQFHQEQHTVTNEYFLGYSKEQSPTNKNVkYFDINFNEQTPEESY 171
                 67777778899999555555555555555555699999************99 PP

>> DUF2845  Protein of unknown function (DUF2845)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.3   2.3e-05      0.14      21      78 ..      62     137 ..      54     138 .. 0.74
   2 ?   -2.3   0.1      0.82   4.9e+03      35      44 ..     311     320 ..     295     332 .. 0.53

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.3e-05
     DUF2845  21 lakCGePlskrkeesesrkkketseqaklqevevee...................WtynfGpnrfvyevrfengklv 78 
                 l++C  P++k++++se++  k+++ ++k+++++ e                    W y+f  n+fv++ + e+  ++
  EFC38741.1  62 LHRCHIPVKKNNSQSEET-VKKETLEEKTERIKKEIvenifpkfisncyfriagwWLYEFCFNKFVRQFHQEQHTVT 137
                 799*******44444444.33444444444444443556****************************9998887775 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.82
     DUF2845  35 sesrkkkets 44 
                 ++++++++++
  EFC38741.1 311 NQQSENNDEN 320
                 2222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (357 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1702  (0.09493); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 2367.43
//
Query:       EFC38742.1  [L=549]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   4.6e-183  609.4   0.5   5.4e-183  609.1   0.5    1.0  1  Carboxyl_trans  Carboxyl transferase domain
  ------ inclusion threshold ------
      0.029   13.9   0.2       0.22   11.0   0.0    2.1  2  MdcE            Malonate decarboxylase gamma subunit (MdcE)


Domain annotation for each model (and alignments):
>> Carboxyl_trans  Carboxyl transferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  609.1   0.5    6e-187  5.4e-183       1     493 [.      65     546 ..      65     547 .. 0.97

  Alignments for each domain:
  == domain 1  score: 609.1 bits;  conditional E-value: 6e-187
                     SSCTTCEEEEEEEEHTTSGGGEBEHHHHHHHHHHHHHHH.HHT..EEEEEEEESBETTEEHHHHTTEEEEESSTTSGGGCEEECHHHHHHHHHTE CS
  Carboxyl_trans   1 kehprGkltareridllldpgsFgeledlffhrvtelgr.kkklprdgvvtgsGaviGravevvaqdktvlggslgpakgekllkaqeeaikage 94 
                     k+h++Gkltareridll+d+gsF+e++++++hr+t++g+ k++ ++dgvvtg G+++Gr v+v++qd+tv+ggsl++++++k++k++++a++ g+
      EFC38742.1  65 KQHQKGKLTARERIDLLVDEGSFREYDAFVRHRATDFGMeKDRPAGDGVVTGHGTINGRLVFVFSQDFTVFGGSLSETHAQKICKIMDKAMEVGA 159
                     69*************************************989999************************************************** PP

                     EEEEEEEE-ESSSGHHSSHHHHHHHHHHHHHHHHHHHCS-EEEEESSEEETHHHHHHHHTSEEEEETTEEEEESSTHHHHHHHHSSCC-SSCHHH CS
  Carboxyl_trans  95 pligindsgGaegriqegveslrgsGkifgenskasgeIpqislvtgrcaGggaYlpalgdrvimveetskifltGpdvikkvlgreevtseelg 189
                     p+igindsgGa  riqegv sl+g++++f++n++asg++pqisl+ g+caGg++Y+pa++d+++mv++ts++f+tGpdv+ +v+  e+vtse+lg
      EFC38742.1 160 PVIGINDSGGA--RIQEGVASLAGYAEVFQRNVNASGVVPQISLICGPCAGGAVYSPAMTDFIFMVRNTSYMFVTGPDVVHSVTR-ETVTSEQLG 251
                     ***********..***********************************************************************9.********* PP

                     HSHHHHTTTTSSSEEESSHHHHHHHHHHHHTTS-SSTTSGGSS----ECSSGSSSH.....HCS-CTTTS---H.HHHHHCEECTTC-EEESTTS CS
  Carboxyl_trans 190 GatqhmtksGvahltaeddeealelirkllsylPkkasnnresaPivetadepdrd...lieivPdnakkpyDv.reviarlvdegeFlEikegy 280
                     Ga++h++ sGvah ++++d e ++ +r+++sylP ++ +n  ++ +++t+d++dr+   l+  vP+++++py++  ++i+ +vd+  F+Ei+++y
      EFC38742.1 252 GAQTHTQVSGVAHRAFDNDIELIKYTREFISYLPSSNRENA-ESRLLATNDPVDRKdmsLDFAVPSDTNAPYNMlSSIIKPIVDDHAFFEIMPDY 345
                     **********************************7777755.55677889*****99877899**********95689***************** PP

                     STTEEEEEEEETTEEEEEEEE--SEEETTEE-HHHHHHHHHHHHHHHHTT--EEEEE-BSEE--SHHHHHTTHHHHHHHHHHHHHT--S-EEEEE CS
  Carboxyl_trans 281 AktvVvGfArlgGipvGvvAnetrveaGqvlfidsavKaarfirlcdaenlPlviladvrGflvGqrqeyggilkhGaklvdalaeakvPkitvi 375
                     Ak++++GfAr++G +v ++An++   aG vl+i+s+ Kaarf+r+ +a+n+P+++++dv+Gfl+G++qeyggi++hGakl+ a+aea+vPkitvi
      EFC38742.1 346 AKNIITGFARMNGETVAIIANQPCELAG-VLDINSSIKAARFVRFANAFNIPILTFVDVPGFLPGTAQEYGGIIRHGAKLLFAYAEATVPKITVI 439
                     ****************************.****************************************************************** PP

                     -TEEEHHHHHTTTGGGSTTTTEEETTT-EEESS-HHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSHHHHHH CS
  Carboxyl_trans 376 lrkayGGayvvmdskingadlvaawptariaVlgpegaveilfrkekaaaemerkdlaaerkkklkeyeeellnpyvaaargfaDavidpsetra 470
                     +rkayGGay vm+sk+++ d+++aw ta iaV+gpegav+i+   e +++           k++++ y++++++p  aa+rgf D+vi+p etr+
      EFC38742.1 440 TRKAYGGAYDVMSSKHLRGDYNYAWSTATIAVMGPEGAVKIIKGIEGETQ-----------KDREETYRNKFATPLLAAERGFLDDVIKPHETRQ 523
                     ******************************************88875544...........577899**************************** PP

                     TTSSSEEEHGGGHHHHHHHHHHH CS
  Carboxyl_trans 471 klvialelewkkarklparkrrn 493
                     +++ +le++ +k++++p++k  n
      EFC38742.1 524 RIIEDLEILRTKKKENPTKKLSN 546
                     **************999998766 PP

>> MdcE  Malonate decarboxylase gamma subunit (MdcE)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1     0.044   3.9e+02      90     125 ..     178     215 ..     102     255 .. 0.70
   2 ?   11.0   0.0   2.5e-05      0.22      20     152 ..     350     482 ..     342     494 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.044
                 HHHHHHHHHHHH.HHHT.--EEEEEEEEEEHHHHHHTT CS
        MdcE  90 alahlakalarA.rlaG.hpvigllvGkavsGaflahg 125
                  la+ a++++r  ++ G  p i+l+ G  + Ga  + +
  EFC38742.1 178 SLAGYAEVFQRNvNASGvVPQISLICGPCAGGAVYSPA 215
                 57888888877425667348899999999999987765 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 2.5e-05
                 EEEEETTEEEEEEEE---TT...SS-B-HHHHHHHHHHHHHHHTSSS--EEEEEEEE--B--SHHHHHHTHHHHHHHHHHHHHHHHHHT--EEEEEEEE CS
        MdcE  20 ldgsltlesvrfvaVigdan...kgevGvdealaLaaaVleaieraekrpilvlvDvasQrlgrrdEllGihealahlakalarArlaGhpvigllvGk 115
                 ++g +   ++ +va+i++      g + ++ +++ a  V     +a + pil  vDv++   g  +E  Gi    a l  a+a A +   p i+++  k
  EFC38742.1 350 ITGFARM-NGETVAIIANQPcelAGVLDINSSIKAARFVRF--ANAFNIPILTFVDVPGFLPGTAQEYGGIIRHGAKLLFAYAEATV---PKITVITRK 442
                 5555555.666777776666222333333344555555543..357789*********************************99986...99******* PP

                 EEHHHH...HHTTTT-SEEEEEET-EEESS-HHHHHHHHT CS
        MdcE 116 avsGaf...lahglqanrlialpgvqvavmdkasaArvTk 152
                 a  Ga+    +  l  +   a   +++avm+   a ++ k
  EFC38742.1 443 AYGGAYdvmSSKHLRGDYNYAWSTATIAVMGPEGAVKIIK 482
                 ****9743245678889999999*******9999988865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (549 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       336  (0.0187406); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 3293.62
//
Query:       EFC38743.1  [L=159]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.6e-12   47.2   0.0    3.1e-12   47.0   0.0    1.0  1  Polyketide_cyc2  Polyketide cyclase / dehydrase and lipid tra
  ------ inclusion threshold ------
       0.03   14.5   0.0      0.034   14.3   0.0    1.3  1  Polyketide_cyc   Polyketide cyclase / dehydrase and lipid tra


Domain annotation for each model (and alignments):
>> Polyketide_cyc2  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.0   0.0   3.4e-16   3.1e-12       2     136 ..       8     151 ..       7     156 .. 0.76

  Alignments for each domain:
  == domain 1  score: 47.0 bits;  conditional E-value: 3.4e-16
                      EEEEEEEEES.S-HHHHHHHHTTTTGGGGT-TTEEEEECSE.STSSS.TTTEEEEE.CCCSSEEEEEEEEEETTTTEEEEEEE.....SSS-TS CS
  Polyketide_cyc2   2 vkvtvsvvia.appekVwalvsdfenwprWhpevarveleg.gggpa.rgvegtvr.vggrgtvreelvevdpegrllsyriv....kpvpvan 87 
                      v+v vs vi+ +++ +Vw+l+++f+++p+W+  va++e++  + +++ +g+ ++++ ++g    re+l++ d ++ +++y +v         ++
       EFC38743.1   8 VNVYVSGVIPnVSASTVWSLIGSFNGLPTWYDTVASSEMDNnQSDNTvGGI-RKLTmKNG-IVQRERLIAMDLRNSSYTYSLVdgipWEGYNND 99 
                      56777878888*****************************84344433555.66663555.568********66********556553344478 PP

                      EEEEEEEEECCET.......EEEEEEEEEEEE--TT--HHHHHHHHHHHHHHHHHH CS
  Polyketide_cyc2  88 yvatwtvtpdggg.......trvtwtgefdagplggpfekpaaakavkgdleagLe 136
                      y at++v+   ++       t ++w++ef +      +e+  +  a++g++e g++
       EFC38743.1 100 YFATISVKSITTNgtdkldnTLLEWKAEFTC----PHGEGKKWQQAIEGIFEYGIK 151
                      9999999996632245676699********8....555566678888888887766 PP

>> Polyketide_cyc  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   3.8e-06     0.034       2      43 ..      18      54 ..      17     128 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3.8e-06
                    SS-HHHHHHHHTTTGGCCSCCCCEEEEEE.SSSEE...EEEE CS
  Polyketide_cyc  2 papadqvyalvadvesypeflphcssvevleeaesglsadle 43
                    +++a++v++l+  ++ +p++   + s+e+ ++  +     ++
      EFC38743.1 18 NVSASTVWSLIGSFNGLPTWYDTVASSEMDNNQSD-----NT 54
                    5799************************9998885.....22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1028.25
//
Query:       EFC38744.1  [L=1030]
Description: hypothetical protein NAEGRDRAFT_73484 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-07   31.2   0.1    3.2e-07   30.2   0.1    1.6  1  F-box-like       F-box-like
     0.0033   17.1   0.1        3.2    7.5   0.0    2.9  2  TPR_11           TPR repeat
     0.0052   16.6   0.0      0.012   15.5   0.0    1.6  1  F-box            F-box domain
  ------ inclusion threshold ------
      0.013   15.1  17.4      0.034   13.7  17.4    1.7  1  VIR_N            Virilizer, N-terminal
       0.26   11.8  14.1       0.67   10.5   3.0    4.5  3  Euplotes_phero   Euplotes octocarinatus mating pheromone prot
       0.29   11.6   6.0        7.7    7.2   0.3    4.9  5  TPR_17           Tetratricopeptide repeat
       0.39   11.1   6.3         23    5.5   0.1    4.4  4  TPR_8            Tetratricopeptide repeat
       0.65   10.3   4.4      1e+02    3.4   0.0    4.5  5  TPR_2            Tetratricopeptide repeat
        1.2    9.4   6.9       0.25   11.6   2.0    2.5  2  DUF1477          Protein of unknown function (DUF1477)
          6    7.6  22.1       0.02   15.6  10.9    2.6  3  NAM-associated   No apical meristem-associated C-terminal dom


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.2   0.1   1.8e-10   3.2e-07       7      46 ..     327     365 ..     326     367 .. 0.95

  Alignments for each domain:
  == domain 1  score: 30.2 bits;  conditional E-value: 1.8e-10
  F-box-like   7 EiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrlv 46 
                 E+Ll+IF+yL+ + L+ ++l++r+++++ + + +LW +l+
  EFC38744.1 327 ELLLKIFEYLDEKALADVSLTSRKFNELSNYD-FLWFNLY 365
                 9****************************999.***9998 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0043       7.7       8      35 ..     773     800 ..     770     801 .. 0.92
   2 !    7.5   0.0    0.0018       3.2      10      28 ..     878     896 ..     877     909 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0043
      TPR_11   8 GkyeeAieaYkkAlkldPdnaeayynLG 35 
                 G ++e+ + Y k l+++P++  a++n G
  EFC38744.1 773 GYLDESSKLYDKCLNIKPEYFHALNNKG 800
                 5589*********************998 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0018
      TPR_11  10 yeeAieaYkkAlkldPdna 28 
                 +e++i++Y++A  l P+n 
  EFC38744.1 878 LEQSIAQYEQAMILEPNND 896
                 79***************96 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   6.6e-06     0.012       9      45 ..     327     363 ..     315     366 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 6.6e-06
                 HHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHH CS
       F-box   9 evlrhILerLplsdllalrrVSkgwrilidsdrlwck 45 
                 e+l++I+e+L+ + l   +++S++++ l + d lw+ 
  EFC38744.1 327 ELLLKIFEYLDEKALADVSLTSRKFNELSNYDFLWFN 363
                 69****************************9999986 PP

>> VIR_N  Virilizer, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7  17.4   1.9e-05     0.034     124     244 ..     416     529 ..     402     546 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.9e-05
       VIR_N 124 ervlsedrvsipPppPapPvkelekedqynaspvrpeprePrtpelipaytgnvastpPpdddeeedaavpetveeekeensekredyleeesP..eer 220
                 +r++ e++  +pP+pP +P    +     n  p+ p+p + +t++ ++   +  a  pPp +++++ ++ ++  +  ++e++ ++++ +e ++P  ee 
  EFC38744.1 416 KRIIYEKTFLPPPTPPEQP--SNSATPTTNTAPTAPPPTDQTTTNAATPSSSSTAAVPPPTQNDNQ-KQDQSNLS--QKESQATNNEQTEIKPPtkEEI 509
                 6777788888889999999..557888999***********9999998888888887777766666.34444444..4556666677777777732222 PP

       VIR_N 221 tslkaeekdseaereeresseeie 244
                  +l++ee+++ +++ee+    +i+
  EFC38744.1 510 EKLQKEEDERKKKEEEE----KIK 529
                 33333333333222222....222 PP

>> Euplotes_phero  Euplotes octocarinatus mating pheromone protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   3.0   0.00037      0.67      75     108 ..     549     581 ..     474     594 .. 0.81
   2 ?    5.0   0.4     0.019        35      76     109 ..     599     633 ..     581     652 .. 0.78
   3 ?    0.5   0.2      0.46   8.2e+02      25      82 ..     924     986 ..     914    1002 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00037
  Euplotes_phero  75 gqnvidvlfetwmvCfndyesCveeadtayaiys 108
                      +nv+ +    wm+C+++ye+C+++ d++++   
      EFC38744.1 549 ANNVYKK-RMLWMLCMDNYETCLMYNDKNWTAAR 581
                     4566666.568******************98655 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.019
  Euplotes_phero  76 qnvidvlfetwmv..CfndyesCveeadtayaiyss 109
                      n +++ +  +m+  C+++++ C+++a +++++ + 
      EFC38744.1 599 TNEAQL-YLAFMLnqCMEKFDVCMKNAPKNDEVLTL 633
                     555555.88999889**************9998775 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.46
  Euplotes_phero  25 lastfqtssklkdacdpysq...yltgC..stndacyessdcsatgndeekcnavgqnvidvl 82 
                     ++st++t  ++  + +   +       C  +t+   y+     a  n++e+c++    +id++
      EFC38744.1 924 VTSTIGTPEQVNSNLEYLYErakVGFKClkNTSLSHYNLACLNAIFNKKEECKNELMACIDIV 986
                     677777777777776543222223345754444444555555677777788877766666654 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       6.1   1.1e+04       5      17 ..     620     632 ..     617     633 .. 0.83
   2 ?    7.2   0.3    0.0043       7.7       1      20 [.     781     800 ..     781     805 .. 0.95
   3 ?    0.2   0.0      0.71   1.3e+03      11      24 ..     850     863 ..     841     877 .. 0.72
   4 ?    0.2   0.0      0.73   1.3e+03       2      21 ..     885     911 ..     884     923 .. 0.71
   5 ?    1.6   0.1      0.26   4.6e+02      13      32 ..     956     975 ..     950     977 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 6.1
      TPR_17   5 aleldPnnadayn 17 
                 ++++ P+n ++++
  EFC38744.1 620 CMKNAPKNDEVLT 632
                 8999****99875 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0043
      TPR_17   1 lylkaleldPnnadaynnLA 20 
                 ly k+l + P ++ a+nn++
  EFC38744.1 781 LYDKCLNIKPEYFHALNNKG 800
                 7*****************98 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.71
      TPR_17  11 nnadaynnLAelll 24 
                 + + a nn+++ ll
  EFC38744.1 850 DFVIARNNYGNMLL 863
                 67889999999887 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.73
      TPR_17   2 ylkaleldPnn.......adaynnLAe 21 
                 y++a+ l+Pnn       a a+ ++Ae
  EFC38744.1 885 YEQAMILEPNNdgcicrcAIAFLMKAE 911
                 99********97766666666666655 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.26
      TPR_17  13 adaynnLAelllknGdlmtA 32 
                 + +++nLA l +  ++++++
  EFC38744.1 956 SLSHYNLACLNAIFNKKEEC 975
                 789*******9988888877 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.1     0.013        23      15      33 ..     773     791 ..     771     792 .. 0.92
   2 ?   -2.5   0.0       4.7   8.4e+03      20      31 ..     838     849 ..     836     850 .. 0.82
   3 ?   -0.6   0.0       1.2   2.2e+03      17      34 .]     878     895 ..     877     895 .. 0.83
   4 ?    5.1   0.3     0.018        31       3      30 ..     958     985 ..     957     985 .. 0.94

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.013
                 T-HHHHHHHHHHHHHHHHH CS
       TPR_8  15 gdyeeAkeyyekaleldpd 33 
                 g ++e+ + y k+l ++p+
  EFC38744.1 773 GYLDESSKLYDKCLNIKPE 791
                 789***************7 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 4.7
                 HHHHHHHHHHHH CS
       TPR_8  20 Akeyyekaleld 31 
                 A   +++++e++
  EFC38744.1 838 ACDLFRRCIEIK 849
                 56679*****96 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHHHHHHH. CS
       TPR_8  17 yeeAkeyyekaleldpdn 34 
                 +e++++ ye+a  l+p+n
  EFC38744.1 878 LEQSIAQYEQAMILEPNN 895
                 589999****98888875 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.018
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekalel 30 
                 ++ynl+++    +++ee k  ++ ++++
  EFC38744.1 958 SHYNLACLNAIFNKKEECKNELMACIDI 985
                 579**********************986 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.12   2.2e+02      18      30 ..     656     668 ..     652     671 .. 0.85
   2 ?    2.3   0.0      0.13   2.3e+02      15      33 ..     773     791 ..     772     792 .. 0.89
   3 ?   -3.3   0.0       8.2   1.5e+04      20      30 ..     838     848 ..     835     849 .. 0.85
   4 ?    3.4   0.0     0.057     1e+02      18      34 .]     879     895 ..     876     895 .. 0.91
   5 ?   -3.2   0.0       7.6   1.4e+04       4      21 ..     959     976 ..     957     984 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.12
       TPR_2  18 eeAleafekAlel 30 
                   A+e fe+Al++
  EFC38744.1 656 RMAHEKFEEALKI 668
                 5699*******98 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.13
       TPR_2  15 gdyeeAleafekAleldPn 33 
                 g ++e  ++++k+l + P+
  EFC38744.1 773 GYLDESSKLYDKCLNIKPE 791
                 6789************997 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 8.2
       TPR_2  20 AleafekAlel 30 
                 A ++f++++e+
  EFC38744.1 838 ACDLFRRCIEI 848
                 8899****997 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.057
       TPR_2  18 eeAleafekAleldPnn 34 
                 e+ ++ +e+A  l+Pnn
  EFC38744.1 879 EQSIAQYEQAMILEPNN 895
                 7899***********98 PP

  == domain 5  score: -3.2 bits;  conditional E-value: 7.6
       TPR_2   4 lynlGlayyklgdyeeAl 21 
                 +ynl+++ +  ++ ee++
  EFC38744.1 959 HYNLACLNAIFNKKEECK 976
                 899999877777777766 PP

>> DUF1477  Protein of unknown function (DUF1477)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.2       7.4   1.3e+04      15      37 ..     156     178 ..     148     183 .. 0.49
   2 ?   11.6   2.0   0.00014      0.25       4      80 ..     519     596 ..     517     623 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 7.4
     DUF1477  15 naaaqqlksivtlsnlvdtskrn 37 
                 n+ +qq + + +ls++ +t+++ 
  EFC38744.1 156 NQVEQQQQLLQSLSDISNTNQAI 178
                 33333323333566666655554 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00014
     DUF1477   4 sskkrtrnsltnaaaqqlksivtlsnlvd.tskrngrklfyelcisfvkklltknslaletlknlfdtiielEralFn 80 
                 ++kk+++++++n+ +q l++  +l n++d +++  ++++   lc+   +++l+ n  ++++++n    +i lE+++ n
  EFC38744.1 519 RKKKEEEEKIKNKSTQFLRKANNLFNAADkANNVYKKRMLWMLCMDNYETCLMYNDKNWTAARNWCVSLIRLEKLVHN 596
                 567888999999999**9***********8889999**********99999999*********************998 PP

>> NAM-associated  No apical meristem-associated C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1       1.8   3.3e+03      66      88 ..      77      99 ..      40     166 .. 0.63
   2 ?   -4.2   0.6        10   1.8e+04      37      48 ..     249     260 ..     226     282 .. 0.47
   3 ?   15.6  10.9   1.1e-05      0.02      35     127 ..     430     541 ..     410     574 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.8
  NAM-associated 66 dsestsssrlkRPiGkkkaKekr 88
                    + es+++ ++++P   +k K k 
      EFC38744.1 77 SVESPQDLNQTKPLEMRKKKMKT 99
                    33334444444444444444332 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 10
  NAM-associated  37 sspatsssestd 48 
                     s p++++s s+ 
      EFC38744.1 249 SPPTDGTSRSEN 260
                     222222221111 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 1.1e-05
  NAM-associated  35 assspatsssestdeedssesssesseesaadsestsssrlkRPiGkkkaKekrke...................askdeealeklasaqkkiak 110
                     + ++p+ s +++t ++ ++ ++++ ++++aa+++s+s+   + P+ +++ K+++++                   ++++ e+l+k ++++kk+++
      EFC38744.1 430 PPEQPSNSATPTTNTAPTAPPPTDQTTTNAATPSSSSTAAVPPPTQNDNQKQDQSNlsqkesqatnneqteikppTKEEIEKLQKEEDERKKKEE 524
                     444444444434443355667777788899999999999************99998888888888888877777766667777777777777777 PP

  NAM-associated 111 kskekkeeae.leekkld 127
                     ++k k+++ + l +k ++
      EFC38744.1 525 EEKIKNKSTQfL-RKANN 541
                     777777665432.33333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1030 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2879  (0.160578); expected 358.6 (0.02)
Passed bias filter:                      619  (0.0345251); expected 358.6 (0.02)
Passed Vit filter:                       102  (0.00568911); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.07u 0.33s 00:00:01.40 Elapsed: 00:00:00.52
# Mc/sec: 5926.37
//
Query:       EFC38745.1  [L=223]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.2e-14   54.4   0.0    2.5e-14   53.4   0.0    1.5  1  GST_N_3       Glutathione S-transferase, N-terminal domain
    1.6e-11   44.3   0.0    3.3e-11   43.3   0.0    1.6  1  GST_N_2       Glutathione S-transferase, N-terminal domain
    5.9e-10   39.3   0.0    1.1e-09   38.5   0.0    1.5  1  GST_N         Glutathione S-transferase, N-terminal domain
  ------ inclusion threshold ------
      0.011   16.4   0.0      0.021   15.6   0.0    1.4  1  GST_N_4       Glutathione S-transferase N-terminal domain
      0.015   15.5   0.0       0.39   11.0   0.0    2.4  2  Glutaredoxin  Glutaredoxin
      0.076   13.1   0.0       0.18   11.8   0.0    1.6  1  GST_C_2       Glutathione S-transferase, C-terminal domain
       0.14   12.4   0.0       0.27   11.5   0.0    1.5  1  GST_C         Glutathione S-transferase, C-terminal domain


Domain annotation for each model (and alignments):
>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.4   0.0   9.8e-18   2.5e-14       1      73 [.      10      87 ..      10      89 .. 0.87

  Alignments for each domain:
  == domain 1  score: 53.4 bits;  conditional E-value: 9.8e-18
                EES-TTSHHHHHHHHHHHHHT-..-...EEEE---TTTTHHHHHHH-TT--SSEEETTS-EEESHHHHHHHHHHHH-G CS
     GST_N_3  1 LygfpaSpyarrvrlaLnekgl..p...vevvevtpgehdeellaknplgkvPvLeddgealtdSlaIidyLeelypg 73
                L++f+ S  ++rvr aL++k+l  +   +ev  +++++ +ee++++np g+vP Le++g+ lt S  Ii+yL+ ++p+
  EFC38745.1 10 LHSFKPSSSSWRVRAALHHKQLweKttiHEVSLLEKDNEKEEYRKVNPMGQVPCLEINGQTLTQSIPIIEYLDVEFPQ 87
                89999*****************55344344455557778**********************************99986 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.3   0.0   1.3e-14   3.3e-11       4      68 ..      18      82 ..      15      84 .. 0.87

  Alignments for each domain:
  == domain 1  score: 43.3 bits;  conditional E-value: 1.3e-14
                HHHHHHHHHHHCT-..-EEEEEEH...-TTSHHHHHHHHCTTTSSSEEE-CTTEEEESHHHHHHHHH CS
     GST_N_2  4 wahRvlialalkgl..ediisvvvlepkgfekseefprlnprgtVPvLwdkdgqvineSseIlryle 68
                 ++Rv+ al++k+l    +i++v+l +k+ ek ee+ ++np g+VP+L + +gq ++ S  I++yl+
  EFC38745.1 18 SSWRVRAALHHKQLweKTTIHEVSLLEKDNEK-EEYRKVNPMGQVPCLEI-NGQTLTQSIPIIEYLD 82
                68************544447778787888886.7***************9.9**************8 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.5   0.0   4.2e-13   1.1e-09       3      75 ..       8      82 ..       6      83 .. 0.85

  Alignments for each domain:
  == domain 1  score: 38.5 bits;  conditional E-value: 4.2e-13
                EEEESSSTSHTHHHHHHHHHHTT-EEEE..EEECSTTTCGGCHHHHHHCTTS-SSEEEETTEEEESHHHHHHHHH CS
       GST_N  3 ltlysirgsprahrirlllaakgveyev..vpldfeageekspellklnplgkvPaLedngkkltESraIleYia 75
                +tl s+ +s+ ++r+r++l +k +  ++   ++ + ++ ++++e+ k+np g+vP Le+ng++lt+S  I eY++
  EFC38745.1  8 ITLHSFKPSSSSWRVRAALHHKQLWEKTtiHEVSLLEKDNEKEEYRKVNPMGQVPCLEINGQTLTQSIPIIEYLD 82
                57888888999*********9988555433677776666666*******************************97 PP

>> GST_N_4  Glutathione S-transferase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.6   0.0   8.2e-06     0.021      28      66 ..      55      92 ..      43     109 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 8.2e-06
     GST_N_4 28 aspkgklPfielngelliadsefiieflkekgvdldael 66
                  p g++P++e+ng+ ++  s +iie+l  ++++   +l
  EFC38745.1 55 VNPMGQVPCLEINGQ-TLTQSIPIIEYLDVEFPQEGGDL 92
                4799***********.************99995544555 PP

>> Glutaredoxin  Glutaredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00015      0.39      13      58 ..      20      69 ..      18      71 .. 0.84
   2 ?    1.9   0.0       0.1   2.6e+02      46      56 ..     177     187 ..     160     190 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00015
                  HHHHHHHHHTTGG....EEEEEGCCSHHHHHHHHHHHTSSSSSEEEETTE CS
  Glutaredoxin 13 kkakrlLkelgvk....feeidvdkdeeireelkelsgvrtvPqvfidgk 58
                   +++++L+ + +     ++e+ +++ ++++ee +++++  +vP++ i+g+
    EFC38745.1 20 WRVRAALHHKQLWekttIHEVSLLEKDNEKEEYRKVNPMGQVPCLEINGQ 69
                  588999988884444458899999999**********************8 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.1
                   TSSSSSEEEET CS
  Glutaredoxin  46 gvrtvPqvfid 56 
                   ++  vPqvf+ 
    EFC38745.1 177 DICLVPQVFVA 187
                   5667*****95 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   7.1e-05      0.18      12      51 ..     140     191 ..     138     211 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 7.1e-05
                 CHCHHHCTTT--.........-SS...CTTC..S--HHHHHHHHHHHHHHHHH CS
     GST_C_2  12 daaldaleahLa.........dsp..flfGd..qptlaDialapflvrlraag 51 
                 ++ l ++e++La         d    f      +++laDi+l p+++ +++++
  EFC38745.1 140 RNGLTVIEKILAenyptqlndD-EykFCVPQygKLSLADICLVPQVFVAKTRT 191
                 6778888888886666555541.1445555566**************999885 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00011      0.27      52      91 ..     172     211 ..     170     213 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00011
                 SSCHHHHHHHHHHHHHHHH.TTTTTTTTSHHHHHHHHHHHT CS
       GST_C  52 kltlADialvpilnwlqrl.glafgqekfpnlkawlerima 91 
                 kl+lADi+lvp + ++ ++  ++++ ++fp   + ++++++
  EFC38745.1 172 KLSLADICLVPQVFVAKTRtSIKVD-TEFPITNKVYSNLIQ 211
                 8************987655055555.****99999888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (223 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       377  (0.0210274); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.42u 0.24s 00:00:00.65 Elapsed: 00:00:00.39
# Mc/sec: 1713.23
//
Query:       EFC38746.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.3e-12   47.3   0.0    3.4e-12   46.7   0.0    1.3  1  Ependymin  Ependymin


Domain annotation for each model (and alignments):
>> Ependymin  Ependymin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.7   0.0   1.9e-16   3.4e-12       6     127 .]      70     187 ..      65     187 .. 0.93

  Alignments for each domain:
  == domain 1  score: 46.7 bits;  conditional E-value: 1.9e-16
   Ependymin   6 qldvlllfkekveYeidlktksCkkkklkepfrplevpdnatflgqvvlGsssapgegvlvnswsgkleeekgkytttvteegCipvsesfsteksgvv 104
                 ++++ + +  ++ Ye+d  t +Ck  +++ +++p+++ +na + g+v++G+s      ++ ++w++ l + + ++++    +  +pv+   ++ ++g+ 
  EFC38746.1  70 SISLYFRHDLQTGYEYDKLTGTCKSFPINGQLQPFCLAQNAVLNGTVTIGGS------LKCSVWNEALRGFNIRLVIAPNPNFGVPVNVITKGGRIGTA 162
                 555666788899***************************************8......***************************************** PP

   Ependymin 105 ttsffdvtl..gisdpnvFipPseC 127
                 +++ff+++    ++d +vF++P  C
  EFC38746.1 163 FQEFFNFQAysTLQDQSVFNVPTSC 187
                 ******9854489***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       651  (0.0363099); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1315.01
//
Query:       EFC38747.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-32  113.6   4.4    8.8e-22   78.4   0.1    2.1  2  DUF778         Protein of unknown function (DUF778)
    0.00099   18.8   0.2     0.0016   18.1   0.2    1.2  1  DUF4796        Domain of unknown function (DUF4796)
     0.0057   16.5   1.9     0.0087   15.9   1.9    1.3  1  Peptidase_C97  PPPDE putative peptidase domain


Domain annotation for each model (and alignments):
>> DUF778  Protein of unknown function (DUF778)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.4   0.1   1.5e-25   8.8e-22       1      53 [.      48     100 ..      48     109 .. 0.94
   2 !   37.0   1.0   7.2e-13   4.3e-09     127     189 .]     110     163 ..     100     163 .. 0.89

  Alignments for each domain:
  == domain 1  score: 78.4 bits;  conditional E-value: 1.5e-25
      DUF778   1 iPvvswlfPfiGHvgicnseGvildFagsyyvaveklafGaparywqlkpllm 53 
                 iP+++w++Pf+GH+gi+ns+G i+dFag+yy++v+++afG+p+ry+++k+ l 
  EFC38747.1  48 IPLITWFLPFVGHMGIANSKGIIHDFAGPYYISVDDFAFGKPTRYLNIKNQLS 100
                 8***********************************************99665 PP

  == domain 2  score: 37.0 bits;  conditional E-value: 7.2e-13
      DUF778 127 adgirsaPdlsssseefqgeeynLltanchsfvalaLnklryedeedwgvvklailvlvkgkw 189
                          ++s ++ f+ + yn++++nch +  ++Ln+++++ + + g+v++ +l++++gk+
  EFC38747.1 110 N--------IKSGAKCFRSKMYNFFCQNCHHYTVHCLNQMKFK-NRNIGIVEIGFLMFFYGKY 163
                 4........78888999**************************.678**************98 PP

>> DUF4796  Domain of unknown function (DUF4796)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.2   2.7e-07    0.0016      75     158 ..      60     146 ..      58     155 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 2.7e-07
     DUF4796  75 HigitdskgkvveydkkG.vqkdeekWeqcv....lvekvseslleqwdevLeqvsseekwskerYeeeshnCydfvLeflkalklael 158
                 H+gi++skg + ++     ++ d+    +      + ++ s++ le++d+ +++   ++ +++++Y+   +nC++++++ l+++k+++ 
  EFC38747.1  60 HMGIANSKGIIHDFAGPYyISVDDFAFGKPTrylnIKNQLSQEQLENYDSNIKS--GAKCFRSKMYNFFCQNCHHYTVHCLNQMKFKNR 146
                 99************9765155666655555532233344455555666666554..5778*************************9875 PP

>> Peptidase_C97  PPPDE putative peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   1.9   1.5e-06    0.0087      80     122 ..      97     142 ..      78     152 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.5e-06
                    E---HHHHHHHHHHHHTT...--GGG-BTTTB-HHHHHHHHHHHHH CS
  Peptidase_C97  80 Tevteeevraileelsse...ytgdkYnLiskNCnhFtdelvdfLt 122
                     ++++e+ +++ ++++s    ++++ Yn++ +NC h+t + ++++ 
     EFC38747.1  97 NQLSQEQLENYDSNIKSGakcFRSKMYNFFCQNCHHYTVHCLNQMK 142
                    578899999999999994467*****************99888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1260  (0.0702772); expected 358.6 (0.02)
Passed bias filter:                      678  (0.0378158); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1307.18
//
Query:       EFC38748.1  [L=366]
Description: hypothetical protein NAEGRDRAFT_73491 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-98  330.5   0.0    1.5e-97  326.8   0.0    1.9  1  Actin     Actin
     0.0088   16.4   0.0       0.24   11.8   0.0    2.4  2  FtsA      Cell division protein FtsA


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  326.8   0.0  1.6e-101   1.5e-97       6     401 ..       9     362 ..       5     364 .. 0.97

  Alignments for each domain:
  == domain 1  score: 326.8 bits;  conditional E-value: 1.6e-101
       Actin   6 avVlDnGssttraGyagedaPkavipslvgkprgrkvea.klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeehpllltepp 103
                  +V+D Gs++t++G++g+daP++++p+++g+ ++ +v +   yvg++al+kr+ l++++p ++G +++ d+ ++++ h +k+el+vdp +hpll++++p
  EFC38748.1   9 GLVFDIGSGHTKCGFSGDDAPRVDLPTCLGQFKKMNVLQlGEYVGSDALSKRGILNISHPFQRGSITNFDHLQKIFAHCFKNELRVDPMDHPLLIADSP 107
                 68*****************************999987666899******************************************************** PP

       Actin 104 lnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtprylikk 202
                  n+ + rek++Ei+fE+f+vpaly++ + v+++ +sg  +g v+DsG++ t + p+++G ++++a+++ ++gG +Lt++l +ll ++            
  EFC38748.1 108 VNTVEGREKIMEILFESFGVPALYFSVQGVMAMQSSGIVSGTVLDSGKELTYALPIYEGKPIRNALQTIPFGGGDLTRSLYSLLLES------------ 194
                 ************************************************************************************996............ PP

       Actin 203 kkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleeeksk 301
                                   +++  t +e+e+  ++K +vc+v+++ e   ++ +++ +++YeLPDg+ +++++ R k++E++F+p+l+  +         
  EFC38748.1 195 ------------------GYQSYTAAEREIAGDAKRKVCYVAQNYE---KELTEPKTEEYELPDGTIMNVSTLRIKATELMFQPQLMDLDFV------- 265
                 ..................77777899***************99998...56778899****************************9988755....... PP

       Actin 302 llgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGss 400
                   g++el+  +i  +d+d+r++L++nivv+GGn+++pg+ eR ++e ++l++++v+ k+  ++  rkys+WiGGSi++s++tf+++w+ ++EYe+ G++
  EFC38748.1 266 --GVHELVNSSIRSSDIDMRKDLFKNIVVCGGNTMFPGFIERFNREFSNLIPSSVECKVSEKP-TRKYSSWIGGSIFSSMSTFREVWLDRHEYEDFGKN 361
                 ..*************************************************************.*********************************98 PP

       Actin 401 v 401
                 v
  EFC38748.1 362 V 362
                 6 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0     0.031   2.8e+02       2      22 ..      11      31 ..      10      70 .. 0.71
   2 !   11.8   0.0   2.7e-05      0.24       2      87 ..     150     314 ..     149     335 .. 0.71

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.031
                EEEE-SSSEEEEEEETTEEEE CS
                xxxxxxxxxxxxxxxxxxxxx RF
        FtsA  2 lvDiGagktdvavaedgalvh 22
                + DiG+g+t++    d+a++ 
  EFC38748.1 11 VFDIGSGHTKCGFSGDDAPRV 31
                56*********9888777665 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 2.7e-05
                 EEEE-SSSEEEEEEETTEEEE..EEEES--HHHHHHH....HHHHHT--HHHHHHHHHHH--S--............EEEEEHHHHH............ CS
                 xxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxx............xxxxxxxxxx............ RF
        FtsA   2 lvDiGagktdvavaedgalvh..lrvigvggngitkd....iakalrtaveeAerikikyGsala............ekeigrkels............ 70 
                 ++D G + t ++ + +g+++   l++i++gg  +t++    + ++  ++  +Aer     G a +                     +            
  EFC38748.1 150 VLDSGKELTYALPIYEGKPIRnaLQTIPFGGGDLTRSlyslLLESGYQSYTAAEREI--AGDAKRkvcyvaqnyekeL--------Tepkteeyelpdg 238
                 78999999988877777766669**************88885555566677776654..4666666777755554440........2344446666667 PP

                 ........................................................GGGGSTTHHHHHHHHH...T CS
                 ........................................................xxxxxxxxxxxxxxxx...x RF
        FtsA  71 ........................................................ggsalpnleelaeral...s 87 
                                                                         g ++ p+++e ++r +    
  EFC38748.1 239 timnvstlrikatelmfqpqlmdldfvgvhelvnssirssdidmrkdlfknivvcgGNTMFPGFIERFNREFsnlI 314
                 7777777777788888888888888999999999999999999999999999999999999999999999974442 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       321  (0.017904); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2346.62
//
Query:       EFC38749.1  [L=400]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-10   40.1   2.0    1.5e-05   24.7   0.0    4.6  4  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
       0.17   11.9   0.0       0.62   10.1   0.0    1.9  2  FR47      FR47-like protein


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.6   0.2    0.0069        61       9      21 ..     162     174 ..     161     175 .. 0.90
   2 !    3.6   0.0    0.0065        58      12      28 ..     201     217 ..     198     218 .. 0.91
   3 !   24.7   0.0   1.6e-09   1.5e-05       1      27 [.     243     269 ..     243     272 .. 0.94
   4 !    3.9   0.0    0.0055        49       4      24 ..     301     321 ..     299     322 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0069
      RCC1_2   9 yHscaLtedGeVl 21 
                 +H ++Lt+d +V+
  EFC38749.1 162 SHHVVLTNDRRVF 174
                 8**********97 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.0065
      RCC1_2  12 caLtedGeVlcWGsNsd 28 
                 ++L +d ++++ G+N++
  EFC38749.1 201 VVLASDKHLYARGDNTF 217
                 7999***********96 PP

  == domain 3  score: 24.7 bits;  conditional E-value: 1.6e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNs 27 
                 +k+v +G +H+++L+e++ ++++G N+
  EFC38749.1 243 IKDVKCGFFHTIVLLENNQIFGCGYNT 269
                 79************************8 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.0055
      RCC1_2   4 vsaGdyHscaLtedGeVlcWG 24 
                 +++ ++ ++++ ++G+V+  G
  EFC38749.1 301 IACSSRGTVVINTNGDVFMAG 321
                 8999999**********9766 PP

>> FR47  FR47-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0      0.74   6.7e+03      19      34 ..     127     142 ..     124     146 .. 0.82
   2 ?   10.1   0.0   6.9e-05      0.62      39      78 ..     198     238 ..     196     245 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.74
                 -TTSSEEEEEE-GGG- CS
        FR47  19 kdggelgalqvlpehr 34 
                   +g++  ++++p+++
  EFC38749.1 127 TRIGIIDYIETDPKFK 142
                 56799999*****998 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 6.9e-05
                 HHHHHHHHHHHHHHS-S-EE.EEEETT-HHHHHHHHHHT-E CS
        FR47  39 gsrlvkalakeiaergktvl.lvvvasNtpsirlyeklGfe 78 
                 gs +v a  k++ +rg++ + + +  +N+ s++++ek+ fe
  EFC38749.1 198 GSGVVLASDKHLYARGDNTFnVFTSVNNDFSSSFFEKIPFE 238
                 67788888999999998776377889999*********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (400 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       449  (0.0250432); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.46
# Mc/sec: 2616.36
//
Query:       EFC38750.1  [L=720]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00024   21.3   0.0    0.00063   19.9   0.0    1.8  1  RNase_H       RNase H


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   3.5e-08   0.00063      50     142 ..       2      79 ..       1      80 [. 0.74

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 3.5e-08
                 HHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSBHTTHHHHHHHHHCHCSSEEEEEE-SCCSSSTHHHHHHHHHHHHHH CS
     RNase_H  50 AvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkpvknkdlaellkelakkkkvqlkwvkgHaGvpkgNemaDrlAkeaa 142
                 A+ +a+k l  +++ n+ tDS+ +++ +++  +     + +++  q+     + + ++    k+ +++l +vkgH+    +N  +D+lAke+a
  EFC38750.1   2 AFLTAIKMLPNHSNANVPTDSQVAIE-VLKKSY-----RGDFQGFQE-----EFFGTI--KDKHLNIHLVKVKGHEDP--ENIIVDKLAKEGA 79 
                 8999**********************.555122.....222333332.....444444..234678*********976..9**********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (720 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       861  (0.0480228); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.30s 00:00:00.98 Elapsed: 00:00:00.48
# Mc/sec: 4472.53
//
Query:       EFC38751.1  [L=405]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-05   24.5   3.3    3.5e-05   24.0   2.8    1.5  1  Tim44     Tim44-like domain
  ------ inclusion threshold ------
        1.2    8.1   8.1        2.8    6.9   8.1    1.6  1  Atg14     Vacuolar sorting 38 and autophagy-related subunit 1


Domain annotation for each model (and alignments):
>> Tim44  Tim44-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   2.8   3.9e-09   3.5e-05      12     125 ..      99     213 ..      96     226 .. 0.89

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 3.9e-09
                 -TT--HHHHHHHHHHTHHHHHHHHHHT-HHHHHHHB-HHHHHHHHHHHHHH.HHTT-EE--EEEEEEEEEEEEEEEE.TTEEEEEEEEEEEEE-EE-TT CS
       Tim44  12 dpsFdkeeFleeakeayepileayakgDletLrkllteevyeefkaeiker.akqgltldaellgirevdlkeakie.gdtavltvrfrtqqisvtdda 108
                 d++F+++eF+e+akea+++i e ++ +D  +L++++t+ +ye fk+  k   +++  +   +l ++ e+++ +++++ +++ ++ vr   + +  ++++
  EFC38751.1  99 DADFNEKEFIEGAKEAFKTIRELLV-EDPTQLEPMFTQSAYEGFKEWYKFItEEKHCKIVGSLENLGETEILNIRVDaDGETIINVRAFDKSKEQIEEE 196
                 99******************99877.69*********************99999999********************9999999999877766667777 PP

                 S.-EEEE-TT--EEEEE CS
       Tim44 109 tGevveGdedkvvevre 125
                 + e +e ++++ ++ re
  EFC38751.1 197 QKEYIEKNKEEFEKARE 213
                 77888888888888777 PP

>> Atg14  Vacuolar sorting 38 and autophagy-related subunit 14
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   8.1   0.00031       2.8      87     157 ..     190     261 ..     167     287 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00031
       Atg14  87 kdkl.sqlkkeieekkkklaklsdklkkRrsdleslqneleerrkkqiaklqdaikrieqklsslssktles 157
                 k+++ +++k+ ie+ k++++k ++++ kR +dle lq   +++  +  +++++++k+ e+k+++l+++  ++
  EFC38751.1 190 KEQIeEEQKEYIEKNKEEFEKAREQTLKREKDLEHLQGVRRKYLFQRKQRYYESLKEEEEKKAQLEREKKQA 261
                 45551467888*********************************************9999999988876553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2351  (0.131128); expected 358.6 (0.02)
Passed bias filter:                      594  (0.0331307); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.27s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 2501.49
//
Query:       EFC38752.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       779  (0.0434492); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.24s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 2335.79
//
Query:       EFC38753.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1782  (0.099392); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.45
# Mc/sec: 2168.81
//
Query:       EFC38754.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       987  (0.0550505); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1551.74
//
Query:       EFC38755.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.7e-16   58.5   0.7    1.9e-15   57.3   0.7    1.7  1  PH              PH domain
  ------ inclusion threshold ------
      0.037   14.4   0.3      0.095   13.0   0.3    1.7  1  Ribosomal_L34e  Ribosomal protein L34e
      0.084   13.3   0.1       0.24   11.8   0.1    1.7  1  NAPRTase_C      Nicotinate phosphoribosyltransferase C-termin
       0.39   11.2   9.0      0.093   13.2   3.9    2.6  3  PH_11           Pleckstrin homology domain


Domain annotation for each model (and alignments):
>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.3   0.7   4.2e-19   1.9e-15       3     104 ..      33     139 ..      31     140 .. 0.93

  Alignments for each domain:
  == domain 1  score: 57.3 bits;  conditional E-value: 4.2e-19
                 EEEEEEEETSSSSCSEEEEEEEEETTEEEEESST.TCTTESSEEEEEESTTEEEEEEEC.....TTSSSSTSEEEEEESTSSSTEEEEEEESSHHHHHH CS
          PH   3 keGwLlkkgsgkkkswkkrwfvLkdsellyyknd.ksekdkepkgsislsncevvevva.....tedpkrkfcfelriverngsrtyllqasseeerke 95 
                 k+G ++k+g + k ++k r+f+L ++++ y+k   k+e++k+p+g+isl+++++  + +     ++  k+  +f +++  +++sr+y+l ++++ee  e
  EFC38755.1  33 KSGVMTKQGAKVK-NYKSRYFFLYSNKITYHKMNkKKEPNKTPQGEISLKGVQSLNIYEmktiePKAQKEGLQFGFIVEDQERSRNYFLFTETKEETLE 130
                 89**********9.*******************99*******************998889999777888889999999988889*************** PP

                 HHHHHHHHH CS
          PH  96 Wikaiqsai 104
                 Wi+ai++++
  EFC38755.1 131 WIEAIRQVV 139
                 ******986 PP

>> Ribosomal_L34e  Ribosomal protein L34e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.3   2.1e-05     0.095      21      66 ..      50      95 ..      35     106 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.1e-05
  Ribosomal_L34e 21 rvvktpggklvyqykkkkgkapkCgdckkkLqGipalrpkelsrls 66
                    r+    ++k++y++ +kk++ +k+ + +  L+G++ l   e+++++
      EFC38755.1 50 RYFFLYSNKITYHKMNKKKEPNKTPQGEISLKGVQSLNIYEMKTIE 95
                    55555689********************************999885 PP

>> NAPRTase_C  Nicotinate phosphoribosyltransferase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   5.5e-05      0.24      19     101 ..     327     412 ..     324     417 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.5e-05
  NAPRTase_C  19 ialadeke..pkegkeilclhpfdekkrveitpsrvekLlkkvfkdGklv...yelpsleeireyvkeqlaelrpehkRllnPtpYkV 101
                 i l+dek+  p+e+  ++ +h+f+++ + +i+ ++++++ ++ +  G+++    e++++++  e++++ ++++r  +  + + t  +V
  EFC38755.1 327 IFLKDEKQrtPQEQAYVIAMHHFRRQMQDHIRRYSCKPVYNLAV--GTVIfciPEEERTADEEEFYQDLMEQFRGNVEMYKQATSIYV 412
                 7789995555999999*************************999..666633346777899999999999999998887777776666 PP

>> PH_11  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   3.9   2.1e-05     0.093       2     104 ..      34     137 ..      33     138 .. 0.63
   2 ?   -3.0   0.1       2.1   9.6e+03      56      74 ..     235     253 ..     222     268 .. 0.47
   3 ?   -3.2   0.0       2.6   1.2e+04      38      48 ..     355     365 ..     328     384 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.1e-05
       PH_11   2 kGylkkkgsk..aWkrrwfavlkdgvLeyYksekkkvvkhviklSngseaklkadlisaalfkidsirssksddllleistetki...fflkgdsneet 95 
                  G++ k+g+k   +k r+f  l   ++ y k +kkk      k  +g+    +++  ++  +k  + +++k+   +  i  ++++   +fl ++++eet
  EFC38755.1  34 SGVMTKQGAKvkNYKSRYF-FLYSNKITYHKMNKKKE---PNKTPQGEISLKGVQSLNIYEMKTIEPKAQKEGLQFGFIVEDQERsrnYFLFTETKEET 128
                 6899999999999******.99999******888887...23444433333333333333333333333333333333333333334489********* PP

       PH_11  96 eeWvealke 104
                  eW+ea+++
  EFC38755.1 129 LEWIEAIRQ 137
                 ******987 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.1
       PH_11  56 isaalfkidsirssksddl 74 
                  s a++++  +++s++++l
  EFC38755.1 235 FSTANTTVLLQKNSHESEL 253
                 3344444444444444333 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.6
       PH_11  38 khviklSngse 48 
                  h+++ S+  +
  EFC38755.1 355 DHIRRYSCKPV 365
                 47777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1021  (0.0569468); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.58
# Mc/sec: 2185.57
//
Query:       EFC38756.1  [L=764]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      1e-64  218.9  15.6    2.1e-64  217.9  15.6    1.5  1  Peptidase_S9_N  Prolyl oligopeptidase, N-terminal beta-propel
      3e-55  187.0   0.0      5e-55  186.3   0.0    1.4  1  Peptidase_S9    Prolyl oligopeptidase family
  ------ inclusion threshold ------
      0.077   12.6   0.1       0.21   11.1   0.0    1.8  2  Peptidase_S15   X-Pro dipeptidyl-peptidase (S15 family)


Domain annotation for each model (and alignments):
>> Peptidase_S9_N  Prolyl oligopeptidase, N-terminal beta-propeller domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  217.9  15.6   3.5e-68   2.1e-64       5     413 ..      58     475 ..      55     476 .. 0.85

  Alignments for each domain:
  == domain 1  score: 217.9 bits;  conditional E-value: 3.5e-68
                     --TT.EEEETTEEEE-TTGGGGSTTSHHHHHHHHHHHHHHHHHHCTST.CHHHHHHHHHHHT-S-EE---EEETTEEEEEEE-SS-SS-EEEEEC CS
  Peptidase_S9_N   5 rdesvvdelhgdkvsDpYrWLeDddspetkayleaenkyteevlaqlkelrekikeeitklikeddisapfrkgkyyyysrneggknqsvlyrqd 99 
                     rde+v ++++  + sDpY+W +++  +++++y++ en y +  ++ lk+l++ki++ei++ i+++++s+p+  ++yyyysr +++k++++++r++
      EFC38756.1  58 RDEKVENSIQVLEHSDPYFWFREK--EKVMDYIKSENTYQKTKMKPLKKLQDKIFNEIKNKIQQNNASVPYIWKDYYYYSRIQEDKQYKIYCRKS 150
                     77777778888889*******975..78******************************************************************9 PP

                     STS-TTS-EEEEE-GGGGST..TS-.EEEEEEEE-TTSSEEEEEEEETTSSEEEEEEEETTTTEEEEEEEEE..EESEEEEECTTSSEEEEEESS CS
  Peptidase_S9_N 100 alskegeeeevlLDpNtlse..dgtfvalgefavsedgkllAyslsksGsdwytirvkdietgedlpdeled..vkfsgivWaadekgffYtryd 190
                     a  k++ +ee+lLD N++++  + ++++lg +++s+d++++Ays++  G++ y++ +kd+++g+ +++ +++  +  ++++   d++++++++ d
      EFC38756.1 151 AMEKDA-KEEILLDLNQIAQefETEYLDLGFYDISPDQNIMAYSIDVDGDEYYEMYFKDLKSGKIIAEYISRdeCLDTSFEFGTDSRTIIFVTCD 244
                     999999.*************88899******************************************99986224456699************** PP

                     -SSS-TSTSB-S-BEEEEEETTS-GGG-..............EEEES-TTGTTBEEEEEE-TTSSEEEEEEESSSS--EEEEEEGGGTSS.--EE CS
  Peptidase_S9_N 191 kedersdtdtnlnqkvyrhkLGtaqseD..............elvfeeeeepkwllgaersedgkylfissasgtdtnelyvldlekesk.kvlk 270
                      e  r++       kvyr +L  +++ D              e+v+  + ++k+ ++a+++  ++++fi+s+s+  t e ++l++++  + +++ 
      EFC38756.1 245 -EAHRPY-------KVYRKTLNVEEQVDniedckrislenecEMVYC-DMNEKFNVAAYKTLTDEFIFIESISNN-TCEYRYLRVDELPSgEFKL 329
                     .889999.......555555544433331111221111111156777.999999999******************.**********988845555 PP

                     EEESSSSS..-EEEEEEETTEEEEEE-.TT-TT-EEEEEETTSSSGGGEEEEE--.SSCEEEEEEECTTEEEEEEEETTEEEEEEEETTTS-... CS
  Peptidase_S9_N 271 lvdnrfda..eysvehnegdrfliltn.dgapnfrlvsvdlndpspsewkelvperekvvleeitvfknylvvsyrkdvlsrvqvvdlkngkv.. 360
                     + +++++   e ++ h+ +d+f++ +n +g++nf+l+++++++p   +  e++p + + ++e+   f+n+l+  +r+++ +++ + d  ng++  
      EFC38756.1 330 FANRERKEgiELYITHH-KDHFYFWHNdEGFVNFKLFKTTVENPDLDNAPEFLPYNPDFYIESLVAFENHLAMFGRSEGVPKLVILD-PNGEKqp 422
                     55554444467777777.7*****99999**********************************************************.7777757 PP

                     ..EEEEEB-SSSSEEEEEE--TT-SEEEEEEEETTCEEEEEEEETTTTCEEEEEE CS
  Peptidase_S9_N 361 ..llfevplpgvgsvssasgekedselfysfsSfltPstiykldlatgelellke 413
                       + f +p +++g ++++   +e++ +++ +sSfltP+t+y+++++t e ++lk+
      EFC38756.1 423 keVEFPEPSYDLGESENY--IYESNLIRLTYSSFLTPETTYEYNMDTHEFKILKQ 475
                     555555555555555544..499**************************999987 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  186.3   0.0   8.3e-59     5e-55       2     209 ..     541     763 ..     540     764 .] 0.94

  Alignments for each domain:
  == domain 1  score: 186.3 bits;  conditional E-value: 8.3e-59
                   ---.HHHHHHHCCT-EEEEE--TTSSTTHCHHHHTTSGGGGHHHHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHHHHHHHHH-GGG-SEEEEESE CS
  Peptidase_S9   2 sfs.selqlladrGyvvvvanirGsggyGeafhdagkrklgqnefdDfiaaaealakegyvdserlaitGgSyGGyltgaalnqrpdlFkaavaevp 97 
                   sfs s ++ll drG++++v  +rG+++ G++++ +gk  +++n+f Dfi+ ae+l+++g++++ +lai+GgS+GG+l+g +l +rp++F+aa+ evp
    EFC38756.1 541 SFSySIFSLL-DRGVIYAVSSVRGGSELGRDWYLQGKLLNKKNTFYDFIDSAEYLIQQGWTNPGKLAIEGGSAGGLLIGSVLCMRPEIFRAAILEVP 636
                   6885666777.************************************************************************************** PP

                   ---CCCHHCSTTS..THHHCCCC--TTTCHHHHHHHHHH-CGGG--.......---EEEEEEETT-SSS-THHHHHHHHHHH....--S-S..EEEE CS
  Peptidase_S9  98 vvdvlrydsdtdl..lteeymewgnpeeneegykelspyspldnvk.......aypplLlihGlaDdrvppaealklvaaLq....kkgkn..vlll 179
                   +vd+++++ d+++    +ey+ewgnp   ++ y+++ +ysp+dn+          p++L+ h+l+D+rv+++e+lk+va+L+     + k+  +l +
    EFC38756.1 637 FVDLISSMMDPSMplCCTEYDEWGNP-TIKKFYDYMIQYSPYDNIDceenvnkPFPSILVDHALNDSRVQYWEGLKFVARLRhfqkTHSKPglILCK 732
                   **************64448*******.99999*************9**998777789***************************984455557999* PP

                   EETTS-SSTTSSHHHH.HHHHHHHHHHHHHC CS
  Peptidase_S9 180 ifpdegHgvgkprakv.eelarllaFlkeal 209
                   +++++gHg++ +r++  +ela  +aF+++++
    EFC38756.1 733 TNMKQGHGGAAQRYEGyKELAFRFAFILSQI 763
                   **************************99876 PP

>> Peptidase_S15  X-Pro dipeptidyl-peptidase (S15 family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.2      0.48   2.9e+03     175     213 ..      85     121 ..      72     148 .. 0.66
   2 ?   11.1   0.0   3.6e-05      0.21      52     143 ..     524     645 ..     457     709 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.48
                    THHHHHHHHHHCHCCCCCCTTHHHTHHHHCCCC--SSSH CS
  Peptidase_S15 175 gdalkaaaryeaasdellaeldrqtpveselletgdyda 213
                     d++k +  y++ + ++l++l+++  +++e+ ++ ++++
     EFC38756.1  85 MDYIKSENTYQKTKMKPLKKLQDK--IFNEIKNKIQQNN 121
                    566677777899999999999998..5555555544443 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 3.6e-05
                    H........................HHHTT-EEEEEE-TTSTTS-S---TT.....TTTHHHHHHHHHHHHHHC.TTEEEEEEEEEECHHHHHHHH CS
  Peptidase_S15  52 v........................fvarGYavVvqdvrGtggSeGeftvg.....dsdeaedgadvidWlakq.pwsnGkVgmtGiSYlGttqll 117
                                             +++rG +  v++vrG  +   ++  +     +++   d+ d  + l +q +   Gk +  G S +G +   
     EFC38756.1 524 HplllygygaysicndasfsysifsLLDRGVIYAVSSVRGGSELGRDWYLQgkllnKKNTFYDFIDSAEYLIQQgWTNPGKLAIEGGSAGGLLIGS 619
                    1455555555555566666666666999***********98888878877778777999999999999******66777***************** PP

                    HCTT--TTEEEEEEECE-S-TCCCCS CS
  Peptidase_S15 118 aaatgvpalkaivpeaaisdlyddyy 143
                    +++ +++  +a++ e++ +dl   ++
     EFC38756.1 620 VLCMRPEIFRAAILEVPFVDLISSMM 645
                    *******************9988544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (764 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       952  (0.0530983); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.53
# Mc/sec: 4352.48
//
Query:       EFC38757.1  [L=753]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-18   65.4  33.4      0.026   14.8   8.0    8.3  8  Bactofilin      Polymer-forming cytoskeletal
  ------ inclusion threshold ------
      0.012   15.8   7.5         60    3.9   0.0    6.7  8  RRM_DME         RRM in Demeter
      0.014   15.4  11.4         20    5.3   0.0    6.6  9  ADAM_spacer1    ADAM-TS Spacer 1
      0.054   13.3   3.9         11    6.0   0.1    3.9  4  DUF1495         Winged helix DNA-binding domain (DUF1495)
       0.17   11.9   1.3       0.49   10.4   1.3    1.8  1  DUF3927         Protein of unknown function (DUF3927)
        0.5   10.0   2.9         34    4.0   0.1    3.6  4  tRNA_anti-like  tRNA_anti-like


Domain annotation for each model (and alignments):
>> Bactofilin  Polymer-forming cytoskeletal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   2.3   0.00022      0.66      17      96 ..      89     176 ..      74     178 .. 0.74
   2 !    7.3   0.3     0.002       5.9      47      95 ..     217     271 ..     165     274 .. 0.44
   3 !   14.8   0.4   8.9e-06     0.027      14      96 ..     242     328 ..     226     349 .. 0.62
   4 !   13.3   1.0   2.6e-05     0.079       3      81 ..     301     401 ..     263     406 .. 0.62
   5 !   14.4   0.0   1.2e-05     0.035       6      97 ..     381     483 ..     378     484 .. 0.81
   6 ?    4.5   0.0     0.014        43       6      28 ..     484     506 ..     482     517 .. 0.90
   7 !   13.8   0.1   1.8e-05     0.053      15      93 ..     525     610 ..     511     617 .. 0.65
   8 !   14.8   8.0   8.6e-06     0.026       1      90 [.     622     716 ..     610     727 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00022
  Bactofilin  17 gdlridGkv..eGdi..eakgklvvgeg.gkvegnikaeevvvaGtvk..Gnveaee.kvelkktakveGdikaksleieegavfeGk 96 
                 ++  ++G++  +G+   +++++l+v+ + ++ +g++++++++++G ++  G v + + ++++++++ ++++i ++ ++++     +G+
  EFC38757.1  89 NSSILNGTLvtNGNFtlNSTHSLHVNGSiAHTDGSMTVGNLTIEGVFNasGIVAMINdSLIVNGSSFINASIDHGLMQVNGSIASNGS 176
                 44455664334666655777888886544888999**********98866888777669****************9999999888887 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.002
  Bactofilin  47 ika.eevvvaGt..vkGnveaeekvelkktakveGdika...ksleieegavfeG 95 
                 + + +++  +G+  ++Gn++  +  e+++t +v+G++++   + l+i+  +v++G
  EFC38757.1 217 VYSnNSLNTNGSltIQGNLTLPSMDEFNGTLQVNGTVNSsisGDLSINGSMVMNG 271
                 3332335555553344555555555555555555555543334455555555555 PP

  == domain 3  score: 14.8 bits;  conditional E-value: 8.9e-06
  Bactofilin  14 evegdlridGkveGdieakgklvvgeggkvegnikaee..vvvaGt..vkGnveaee.kvelkktakveGdika.ksleieegavfeGk 96 
                 e++g+l+++G+v+ +i  +g+l ++ + + +g+ + +e    ++G+   +G+   ++ +v+l+++ + +G+++  ++ +i+   +++G+
  EFC38757.1 242 EFNGTLQVNGTVNSSI--SGDLSINGSMVMNGSFNGNEtdFNMNGSlvHNGSFFQDNeTVHLNGSMNFDGNMSLpSNTSINGTISVNGT 328
                 5677777777777777..44677777777777777744236666774333555555556666666666666666333445555555554 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 2.6e-05
  Bactofilin   3 igegtkikGelevegdlridGkv..eGdi..eakgklvvgeggkvegnika...eevvvaGtvk...............GnveaeekvelkktakveGd 79 
                 ++ +++++G+++  ++  i+G++  +G+    + g l v+ +  ++g+ +    ++++++Gt+                G+++++++++l ++ +++G+
  EFC38757.1 301 LNGSMNFDGNMSLPSNTSINGTIsvNGTFksMSMGVLSVNGSMLINGSFSTnqtNSLELNGTLAnngsfvhdnssmssnGSITIDGNMTLPSNNSINGT 399
                 455677777777777777777443377774444667777777777777665322347777775545444444444444455555555555555555555 PP

  Bactofilin  80 ik 81 
                 i+
  EFC38757.1 400 IS 401
                 44 PP

  == domain 5  score: 14.4 bits;  conditional E-value: 1.2e-05
  Bactofilin   6 gtkikGelevegdlridGkv..eGdi..eakgklvvgeggkvegnika...eevvvaGtvk..Gnveaee.kvelkktakveGdikaksle.ieegavf 93 
                 +++i+G+++  ++  i+G++  +G++  +a ++l ++ +  ++g+ ++   ++++++Gt+   G+ + ++ +++ +++  +eG+++ +sl+ i+   ++
  EFC38757.1 381 SITIDGNMTLPSNNSINGTIsvNGTLrsTAFRTLSINGSMLINGSFSSnytNSLELNGTLAnnGSFYHDNsSMSSNGSLAMEGNMTLPSLDsINGTLQI 479
                 67999****99999****6545999*766678*************99855456******55348998886677777777888********867778899 PP

  Bactofilin  94 eGkl 97 
                 +G++
  EFC38757.1 480 NGSI 483
                 9976 PP

  == domain 6  score: 4.5 bits;  conditional E-value: 0.014
  Bactofilin   6 gtkikGelevegdlridGkveGd 28 
                 +++++G+l+++g++ i+G+++G+
  EFC38757.1 484 NSTMDGQLSINGSMLINGSFDGN 506
                 57899****************98 PP

  == domain 7  score: 13.8 bits;  conditional E-value: 1.8e-05
  Bactofilin  15 vegdlridG..kveGdieakgklvvgeggkvegnikaee...vvvaGt..vkGnveaeekvelkktakveGdikaksleieegavf 93 
                  +++++++G  +++G+++  ++  ++ + +v+g+ k+ +   ++v+G+  ++G++  +e++el+++   +G+ ++++ +i +++++
  EFC38757.1 525 DNETVHLNGsmNFDGNMSLPSNTSINGTISVNGTFKSMSmgvLSVNGSmlINGSLLGNETLELNGSLAQNGSFEMDNSSIASNGSL 610
                 45777777744457777777777777777777776663323367777766677777777777777777777777777666665543 PP

  == domain 8  score: 14.8 bits;  conditional E-value: 8.6e-06
  Bactofilin   1 tligegtkikGeleve..gdlridG..kveGdieakgklvvgeggkvegnikaeevvvaGtvk.GnveaeekvelkktakveGdikaksleieeg 90 
                 tli+ +++++G+l+++  + l ++G  +v+G+++ ++ l +  + +++g+++ ++   a  v+ G+ ++ + + +++ta+v+G+ ++ks ++e+ 
  EFC38757.1 622 TLINGNLTVNGTLNSTvgSILTVNGetHVNGNLTLNHALLITGNLTINGTVHLNHSNAAIIVQgGDFTSIGGIVVNGTAVVSGTFSVKSTDVESS 716
                 67999999999988665366788886677999999999999999999999999765554455536999999****************99999985 PP

>> RRM_DME  RRM in Demeter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.92   2.8e+03      11      38 ..      99     127 ..      93     150 .. 0.76
   2 ?    3.8   0.1     0.021        63      11      28 ..     282     299 ..     268     311 .. 0.87
   3 ?   -0.3   0.0      0.42   1.2e+03       3      21 ..     311     329 ..     309     343 .. 0.85
   4 ?   -1.3   0.0      0.83   2.5e+03      13      37 ..     355     378 ..     341     417 .. 0.55
   5 ?   -3.5   0.0       4.2   1.2e+04      16      34 ..     435     453 ..     429     468 .. 0.62
   6 ?    3.7   0.1     0.023        69      11      28 ..     512     529 ..     507     538 .. 0.85
   7 ?   -0.4   0.0      0.44   1.3e+03       3      21 ..     541     559 ..     539     570 .. 0.86
   8 ?    3.9   0.0      0.02        60       1      21 [.     614     634 ..     614     681 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.92
     RRM_DME  11 mrGsfPlnGty.fqvnevfadhesslnpi 38 
                 ++G+f ln t+ + vn   a  + s++  
  EFC38757.1  99 TNGNFTLNSTHsLHVNGSIAHTDGSMTVG 127
                 6899****997467888888777776655 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.021
     RRM_DME  11 mrGsfPlnGtyfqvnevf 28 
                 m+Gs+  nG++fq ne  
  EFC38757.1 282 MNGSLVHNGSFFQDNETV 299
                 899999*********964 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.42
     RRM_DME   3 iliPcrtamrGsfPlnGty 21 
                 + +P  t+ +G+  +nGt+
  EFC38757.1 311 MSLPSNTSINGTISVNGTF 329
                 668999************8 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.83
     RRM_DME  13 GsfPlnGtyfqvnevfadhesslnp 37 
                  s+ lnGt    n  f+ ++ss+++
  EFC38757.1 355 NSLELNGTLAN-NGSFVHDNSSMSS 378
                 55667777544.4444444444332 PP

  == domain 5  score: -3.5 bits;  conditional E-value: 4.2
     RRM_DME  16 PlnGtyfqvnevfadhess 34 
                  lnGt       + d++s 
  EFC38757.1 435 ELNGTLANNGSFYHDNSSM 453
                 5777765554444444443 PP

  == domain 6  score: 3.7 bits;  conditional E-value: 0.023
     RRM_DME  11 mrGsfPlnGtyfqvnevf 28 
                 m+Gs+  nG++fq ne  
  EFC38757.1 512 MNGSLVHNGSFFQDNETV 529
                 89*************964 PP

  == domain 7  score: -0.4 bits;  conditional E-value: 0.44
     RRM_DME   3 iliPcrtamrGsfPlnGty 21 
                 + +P  t+ +G+  +nGt+
  EFC38757.1 541 MSLPSNTSINGTISVNGTF 559
                 668999************8 PP

  == domain 8  score: 3.9 bits;  conditional E-value: 0.02
     RRM_DME   1 GtiliPcrtamrGsfPlnGty 21 
                 G i +Pc t  +G++ +nGt 
  EFC38757.1 614 GNISLPCSTLINGNLTVNGTL 634
                 67889**************96 PP

>> ADAM_spacer1  ADAM-TS Spacer 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.013        40      47      98 ..      94     144 ..      87     149 .. 0.87
   2 ?    3.4   0.0     0.025        74      46      88 ..     186     228 ..     166     238 .. 0.79
   3 ?   -2.8   0.0       2.1   6.2e+03      48      71 ..     245     268 ..     235     285 .. 0.71
   4 ?    5.3   0.0    0.0067        20      43      87 ..     336     380 ..     320     390 .. 0.76
   5 ?    3.0   0.1     0.033        99      46      87 ..     416     457 ..     397     466 .. 0.76
   6 ?   -0.6   0.0      0.44   1.3e+03      44      71 ..     471     498 ..     460     516 .. 0.80
   7 ?   -1.8   0.0       1.1   3.2e+03      47      84 ..     494     530 ..     485     537 .. 0.63
   8 ?   -2.5   0.0       1.7   5.1e+03      45      55 ..     568     578 ..     547     611 .. 0.55
   9 ?   -2.1   0.1       1.3   3.9e+03      47      70 ..     645     672 ..     624     685 .. 0.61

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.013
  ADAM_spacer1  47 dgeylLngeltisaseklelagtvleysrsdeakesleatgplkesltvqvl 98 
                   +g+ + ng++t++  ++l+++g + + ++s++   +l+ +g  ++s +v ++
    EFC38757.1  94 NGTLVTNGNFTLNSTHSLHVNGSIAHTDGSMT-VGNLTIEGVFNASGIVAMI 144
                   577889***********************988.8999999988887777766 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.025
  ADAM_spacer1  46 sdgeylLngeltisaseklelagtvleysrsdeakesleatgp 88 
                   s+g+  +ng +  ++ +++el+gt  +       ++sl+++g 
    EFC38757.1 186 SNGSLFINGSFDADEVNAFELNGTLGHNGSFVYSNNSLNTNGS 228
                   57999*******************8766554445566666554 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 2.1
  ADAM_spacer1  48 geylLngeltisaseklelagtvl 71 
                   g+  +ng ++ s s++l ++g ++
    EFC38757.1 245 GTLQVNGTVNSSISGDLSINGSMV 268
                   555667777777777777777654 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.0067
  ADAM_spacer1  43 lknsdgeylLngeltisaseklelagtvleysrsdeakesleatg 87 
                   + + +g++l+ng ++ ++ ++lel+gt  +     + + s++++g
    EFC38757.1 336 VLSVNGSMLINGSFSTNQTNSLELNGTLANNGSFVHDNSSMSSNG 380
                   445789********************9987665555555555555 PP

  == domain 5  score: 3.0 bits;  conditional E-value: 0.033
  ADAM_spacer1  46 sdgeylLngeltisaseklelagtvleysrsdeakesleatg 87 
                    +g++l+ng ++ +  ++lel+gt  +     + + s++++g
    EFC38757.1 416 INGSMLINGSFSSNYTNSLELNGTLANNGSFYHDNSSMSSNG 457
                   4699********************987666655556666555 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.44
  ADAM_spacer1  44 knsdgeylLngeltisaseklelagtvl 71 
                    + +g+  +ng ++ ++ ++l ++g +l
    EFC38757.1 471 DSINGTLQINGSINSTMDGQLSINGSML 498
                   5567888899999999999999998875 PP

  == domain 7  score: -1.8 bits;  conditional E-value: 1.1
  ADAM_spacer1  47 dgeylLngeltisaseklelagtvleysrsdeakesle 84 
                   +g++l+ng +  ++  +++++g  ++     + +e+++
    EFC38757.1 494 NGSMLINGSFDGNE-TDFNMNGSLVHNGSFFQDNETVH 530
                   56777777776543.34777777777666555555555 PP

  == domain 8  score: -2.5 bits;  conditional E-value: 1.7
  ADAM_spacer1  45 nsdgeylLnge 55 
                   + +g++l+ng 
    EFC38757.1 568 SVNGSMLINGS 578
                   23344444443 PP

  == domain 9  score: -2.1 bits;  conditional E-value: 1.3
  ADAM_spacer1  47 dgeylLngeltisas....eklelagtv 70 
                   +ge  +ng+lt++++    ++l+++gtv
    EFC38757.1 645 NGETHVNGNLTLNHAllitGNLTINGTV 672
                   4566666666655431211445555555 PP

>> DUF1495  Winged helix DNA-binding domain (DUF1495)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.26   7.7e+02      29      67 ..      62     100 ..      57     121 .. 0.82
   2 ?    6.0   0.1    0.0036        11      42      63 ..     269     290 ..     250     301 .. 0.84
   3 ?   -3.1   0.1       2.5   7.4e+03      41      63 ..     435     457 ..     428     464 .. 0.74
   4 ?    5.3   0.0    0.0056        17      42      63 ..     499     520 ..     493     531 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.26
     DUF1495  29 qeisrrvrskpsnvkGaleGmgkrynsessLielGLvee 67 
                 q+ s+ +  + sn    ++G+ +  +s+ss+++  Lv++
  EFC38757.1  62 QNASETTIFSDSNGNATMKGFYTTTSSNSSILNGTLVTN 100
                 666777788888999999999999999999999888864 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0036
     DUF1495  42 vkGaleGmgkrynsessLielG 63 
                 + G+ +G+++ +n + sL++ G
  EFC38757.1 269 MNGSFNGNETDFNMNGSLVHNG 290
                 57******************99 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.5
     DUF1495  41 nvkGaleGmgkrynsessLielG 63 
                 ++ G l+ +g  y+ +ss+ + G
  EFC38757.1 435 ELNGTLANNGSFYHDNSSMSSNG 457
                 67889999999999988887777 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.0056
     DUF1495  42 vkGaleGmgkrynsessLielG 63 
                 + G+  G+++ +n + sL++ G
  EFC38757.1 499 INGSFDGNETDFNMNGSLVHNG 520
                 68******************99 PP

>> DUF3927  Protein of unknown function (DUF3927)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   1.3   0.00016      0.49      12      42 ..     706     734 ..     699     741 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00016
     DUF3927  12 FlvlsvlvdfsSrIlSVLsDGvLVAvvVvlv 42 
                 F v s   d  S I+SV +DG+L A  V+ +
  EFC38757.1 706 FSVKST--DVESSIVSVSADGALRADNVITA 734
                 555566..999************99988765 PP

>> tRNA_anti-like  tRNA_anti-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       2.1   6.2e+03      93     127 ..     139     175 ..     137     188 .. 0.75
   2 ?    4.0   0.1     0.011        34     113     158 ..     295     340 ..     289     343 .. 0.85
   3 ?   -4.1   0.0       3.4     1e+04     135     154 ..     471     490 ..     459     494 .. 0.76
   4 ?    4.0   0.1     0.011        34     113     158 ..     525     570 ..     518     573 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.1
                     EEEEEEEE..-STT-EEEEEE-TT-S-S--EEEEEEG CS
  tRNA_anti-like  93 Gvvsdikk..ieassvvvlardddgltnVrclledea 127
                     G+v  i++  i + s+++ a+ d+gl++V+  + ++ 
      EFC38757.1 139 GIVAMINDslIVNGSSFINASIDHGLMQVNGSIASNG 175
                     8888884447778888999999999999998777665 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.011
                     TT-S-S--EEEEEEGGHHHHHH--TTSEEEEEEE-----SS-EEEE CS
  tRNA_anti-like 113 ddgltnVrclledeateasaakiskGqkvtivGqvngvsidnvllr 158
                     d+++++ +  ++++ + +   + s++ ++ + G+++ +s+++  ++
      EFC38757.1 295 DNETVHLNGSMNFDGNMSLPSNTSINGTISVNGTFKSMSMGVLSVN 340
                     57778888889988877777899******************98887 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 3.4
                     --TTSEEEEEEE-----SS- CS
  tRNA_anti-like 135 iskGqkvtivGqvngvsidn 154
                     +s++ +++i G +n   +++
      EFC38757.1 471 DSINGTLQINGSINSTMDGQ 490
                     67889999999999887765 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.011
                     TT-S-S--EEEEEEGGHHHHHH--TTSEEEEEEE-----SS-EEEE CS
  tRNA_anti-like 113 ddgltnVrclledeateasaakiskGqkvtivGqvngvsidnvllr 158
                     d+++++ +  ++++ + +   + s++ ++ + G+++ +s+++  ++
      EFC38757.1 525 DNETVHLNGSMNFDGNMSLPSNTSINGTISVNGTFKSMSMGVLSVN 570
                     57778888889998877777899******************98887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (753 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      205  (0.011434); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.88u 0.32s 00:00:01.20 Elapsed: 00:00:00.52
# Mc/sec: 4376.25
//
Query:       EFC38758.1  [L=576]
Description: glucocorticoid receptor DNA binding factor [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-40  138.2   0.1    4.1e-40  137.1   0.1    1.5  1  RhoGAP    RhoGAP domain
    2.8e-20   72.5   0.0    5.5e-20   71.6   0.0    1.5  1  C2        C2 domain
    2.7e-06   27.8   1.3    6.5e-06   26.6   0.3    2.3  3  PH        PH domain
     0.0089   15.8   1.7       0.76    9.6   1.3    2.3  2  PH_13     Pleckstrin homology domain


Domain annotation for each model (and alignments):
>> RhoGAP  RhoGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.1   0.1   9.2e-44   4.1e-40       1     149 [.     338     487 ..     338     490 .. 0.97

  Alignments for each domain:
  == domain 1  score: 137.1 bits;  conditional E-value: 9.2e-44
                 BHHHHHHHHHHHHHTTTSTTTTTS-S-HHHHHHHHHHHHHTGGGCT.TTTTSCHHHHHHHHHHHHHHSSSTTTTGGHHHHHHHHHTSSSHHHHHHHHHH CS
      RhoGAP   1 PiivekcvefiekrgldtegiyRvsgskarvkelreafdkgkavds.dleeedvhavaslLKrfLrelpepLltkelyeelieaaksedeeerlealke 98 
                 P i +kc++ ++++ l+teg++Rv+g+k+r+++ + +fd+++++d   +e ed h++ +lLK+fLrelpep +++ ly++++++ k+ d++e++++l+e
  EFC38758.1 338 PDICYKCISRLYQNNLTTEGLFRVPGNKNRMRAYEIQFDQNPDQDIqFSEGEDEHTIGGLLKLFLRELPEPPIPHALYSSVLQLDKISDKNEKIDHLRE 436
                 77899***************************************9999999************************************************ PP

                 HHTTS-HHHHHHHHHHHHHHHHHHHTHHHH---HHHHHHHHHHHHHT-TSS CS
      RhoGAP  99 llekLPkenrdtLryLlehLkrvaenskenkMtaknLaivfaPtLlrpkse 149
                 +++kLP++n+ +L++++ +L+r+++ s+ n+M+  nLaivf+P +  p+s+
  EFC38758.1 437 IMHKLPEHNYFLLQCMCCLLHRITRFSHINMMKETNLAIVFGPVFAYPPSS 487
                 ********************************************9998875 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.6   0.0   1.2e-23   5.5e-20       2     103 .]     188     290 ..     187     290 .. 0.96

  Alignments for each domain:
  == domain 1  score: 71.6 bits;  conditional E-value: 1.2e-23
                 EEEEEEEEEESSSSSST...TSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHHH CS
          C2   2 klevtvieAknLpnkdk...kgssdpyvkvsldgkqkakTrviknslnPvWnekftfevaeleeakLeveVfdndrlskddfiGkveiplstllsgeea 97 
                 k+ v++ eAk+L++ d    +g  dpy ++++ ++++  T+v +n+l+P+W e+f+fe++      L+v  fd+dr+ +dd++G+v +++++   g+ +
  EFC38758.1 188 KVYVKIREAKDLEKHDTalmGGLADPYLVLNM-EHKVEHTKVEQNTLEPKWREEFQFEISR-LPCDLHVIMFDKDRFHSDDIMGQVVVKIESARAGADK 284
                 5789********9999999999**********.********99******************.8899********************************* PP

                 HEEEEH CS
          C2  98 egwypl 103
                 e+w+pl
  EFC38758.1 285 EDWFPL 290
                 ****97 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.6   0.3   1.4e-09   6.5e-06       2     104 ..      20     123 ..      19     124 .. 0.79
   2 ?   -3.7   0.0       3.8   1.7e+04      67      90 ..     356     378 ..     343     381 .. 0.63
   3 ?   -2.7   0.0       1.9   8.6e+03      28      48 ..     525     541 ..     520     566 .. 0.66

  Alignments for each domain:
  == domain 1  score: 26.6 bits;  conditional E-value: 1.4e-09
                 EEEEEEEEETSSSSC......SEEEEEEEEETTEEEEESSTTCTTESSEEEEEESTTEEEEEEECTTSSSSTSEEEEEESTSSSTEEEEEEESSHHHHH CS
          PH   2 vkeGwLlkkgsgkkk......swkkrwfvLkdsellyykndksekdkepkgsislsncevvevvatedpkrkfcfelriverngsrtyllqasseeerk 94 
                 v++G+L++k+ +  +      sw+  w++++++ +++++++   + +  + +  + ++e +    +e+++ + ++++++  ++  + y++ + s +e+ 
  EFC38758.1  20 VRQGYLYRKTIKSQGrnllrpSWRINWVIVTTQGIFFFDPH---RVEATQAKAYILTTEPRLKFIDESKNDEKKYQITLE-SD-ISHYVIVFQSWDEKD 113
                 79*****888777778899************999*******...777777777777777665554456666666666444.22.499************ PP

                 HHHHHHHHHH CS
          PH  95 eWikaiqsai 104
                  W++a+++a+
  EFC38758.1 114 LWLRALKQAM 123
                 *******997 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 3.8
                 TSEEEEEESTSSSTEEEEEEESSH CS
          PH  67 kfcfelriverngsrtyllqasse 90 
                 +  f++  ++++  r y +q++ +
  EFC38758.1 356 EGLFRVPGNKNR-MRAYEIQFDQN 378
                 555666444444.49999998865 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.9
                 TEEEEESSTTCTTESSEEEEE CS
          PH  28 sellyykndksekdkepkgsi 48 
                 ++l+y++n       + k si
  EFC38758.1 525 DCLVYCENN----WTKFKQSI 541
                 589999999....44444444 PP

>> PH_13  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.6   1.3   0.00017      0.76      94     153 ..      82     145 ..      50     149 .. 0.72
   2 !    4.2   0.0    0.0077        35      38      91 ..     205     259 ..     197     286 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00017
                 SS-.----EEEE...EESSEEEEEEESSHHHHHHHHHHHHHHHHHHHHH..HTTXXXXXXXXXXX CS
       PH_13  94 dksdssekvlkl...sdidkvitlkaesanersaWvkkikeAsekyiet..ekkkrekayraksq 153
                 d+s+++ek +++   sdi++ +++  +s  e+++W++ +k+A e+  et  +k++ +k+ r + q
  EFC38758.1  82 DESKNDEKKYQItleSDISH-YVIVFQSWDEKDLWLRALKQAMEQARETilKKTTSKKNVRNEDQ 145
                 55555555555533355555.8888899*****************99993334444455554444 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0077
                 EEEEEEESSEEEEEEEE----.-------S-SS..--EEEEE-SS-EETTSEEEE- CS
       PH_13  38 ElvgFLfNDFlLltqpvkklsvssaqeklfesk..snaqfklYkkpiflnevlvkk 91 
                  l+g L   +l+l     k+  +++++ ++e k  ++ qf + + p+ l+ ++  k
  EFC38758.1 205 ALMGGLADPYLVLNMEH-KVEHTKVEQNTLEPKwrEEFQFEISRLPCDLHVIMFDK 259
                 67888888888887775.78889********9987899***********9998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1250  (0.0697194); expected 358.6 (0.02)
Passed bias filter:                      604  (0.0336884); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 3332.47
//
Query:       EFC38759.1  [L=156]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.7e-40  131.7  20.6    1.9e-11   42.7   0.2    4.1  4  EF-hand_1        EF hand
    7.2e-34  116.1   8.7    1.6e-16   60.5   0.5    2.1  2  EF-hand_7        EF-hand domain pair
    1.4e-31  105.6  12.6      2e-09   36.6   0.1    4.3  4  EF-hand_6        EF-hand domain
    6.7e-29   99.5  17.0    4.1e-12   45.8   0.7    4.1  4  EF-hand_8        EF-hand domain pair
    2.1e-28   96.5  19.0    1.8e-08   33.5   0.1    4.5  4  EF-hand_5        EF hand
    4.2e-14   52.6   0.1    3.9e-06   27.1   0.0    2.2  2  EF-hand_9        EF-hand domain
    1.8e-08   34.7   0.7     0.0025   18.1   0.1    2.3  2  SPARC_Ca_bdg     Secreted protein acidic and rich in cysteine
    1.7e-06   27.9   8.5     0.0042   17.0   0.5    3.1  3  EF-hand_4        Cytoskeletal-regulatory complex EF hand
      6e-05   23.0   3.0       0.26   11.2   0.2    3.6  3  Caleosin         Caleosin related protein
     0.0005   20.0   0.1      0.012   15.6   0.1    2.5  2  UPF0154          Uncharacterised protein family (UPF0154)
     0.0011   19.3   0.7        1.3    9.4   0.1    2.6  2  EF-hand_14       EF-hand domain
     0.0051   17.7   0.2        1.3    9.9   0.1    2.1  2  EF-hand_11       EF-hand domain
  ------ inclusion threshold ------
      0.028   14.6   0.2        3.5    7.8   0.1    2.2  2  DUF2666          Protein of unknown function (DUF2666)
      0.045   13.9   0.5       0.73   10.0   0.2    2.8  3  p25-alpha        p25-alpha
      0.048   13.5   0.7      0.083   12.7   0.5    1.6  1  SurA_N_2         SurA N-terminal domain
      0.056   13.6   0.9       0.09   12.9   0.2    1.9  2  EFhand_Ca_insen  Ca2+ insensitive EF hand
      0.075   13.0   0.1       0.93    9.4   0.0    2.3  3  TerB             Tellurite resistance protein TerB
       0.11   12.9   0.0         14    6.2   0.0    2.2  2  DUF4497          Protein of unknown function (DUF4497)
       0.12   12.2   1.3       0.36   10.7   0.2    2.2  2  SUB1_ProdP9      SUB1 protease Prodomain ProdP9
       0.14   11.1   0.0       0.26   10.2   0.0    1.4  1  Glyco_hydro_56   Hyaluronidase
       0.29   11.0   7.6          2    8.4   0.4    3.4  3  EF-hand_10       EF hand
        1.1    9.4   5.2        1.6    8.9   0.2    3.3  4  Mst1_SARAH       C terminal SARAH domain of Mst1
        2.1    9.4   7.6        2.1    9.4   3.6    2.5  2  DUF4834          Domain of unknown function (DUF4834)


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   0.3   1.4e-12   1.1e-09       1      29 []      13      41 ..      13      41 .. 0.96
   2 !   31.9   1.6   6.8e-11   5.3e-08       1      27 [.      49      75 ..      49      77 .. 0.94
   3 !   42.7   0.2   2.4e-14   1.9e-11       1      29 []      86     114 ..      86     114 .. 0.96
   4 !   32.7   1.4   3.8e-11   2.9e-08       1      28 [.     122     149 ..     122     150 .. 0.95

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 1.4e-12
                HHHHHHHHHTTTSSSEEEHHHHHHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfkellkkl 29
                elk++F++fD+DgdGkI++eE+ ++lkkl
  EFC38759.1 13 ELKDAFSLFDQDGDGKISIEELGAVLKKL 41
                79************************996 PP

  == domain 2  score: 31.9 bits;  conditional E-value: 6.8e-11
                HHHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfkellk 27
                el+ +F+++D+D++G+I+feEf+++++
  EFC38759.1 49 ELQLMFSDVDQDNNGTIEFEEFMKMME 75
                6889*********************96 PP

  == domain 3  score: 42.7 bits;  conditional E-value: 2.4e-14
                 HHHHHHHHHTTTSSSEEEHHHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellkkl 29 
                 e++e+Fr+fDk++dG+I++eE+k+++++l
  EFC38759.1  86 EIREAFRVFDKNNDGFISYEELKSMMSSL 114
                 79************************985 PP

  == domain 4  score: 32.7 bits;  conditional E-value: 3.8e-11
                 HHHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellkk 28 
                 el+e++r +D+Dg+G +dfeEfk++++k
  EFC38759.1 122 ELNEMIRQADRDGNGVVDFEEFKSIFMK 149
                 799**********************986 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.5   0.5     2e-19   1.6e-16       3      71 .]      13      75 ..      11      75 .. 0.96
   2 !   59.7   2.4   3.5e-19   2.8e-16       2      70 ..      85     147 ..      84     148 .. 0.96

  Alignments for each domain:
  == domain 1  score: 60.5 bits;  conditional E-value: 2e-19
   EF-hand_7  3 klkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlklyr 71
                +lk+aF ++D+dgdg+++ eel  +l+        g  +s eel+l+f ++D+d++G+i f+EF+k+++
  EFC38759.1 13 ELKDAFSLFDQDGDGKISIEELGAVLK------KLGQCPSAEELQLMFSDVDQDNNGTIEFEEFMKMME 75
                79*********************9999......899999***************************995 PP

  == domain 2  score: 59.7 bits;  conditional E-value: 3.5e-19
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkly 70 
                 ++++eaF+ +D+++dg++++eel++++       + g+ l+d+el ++++  D d++Gv++f+EF+ ++
  EFC38759.1  85 DEIREAFRVFDKNNDGFISYEELKSMMS------SLGETLTDKELNEMIRQADRDGNGVVDFEEFKSIF 147
                 789************************9......*******************************9876 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.1   0.3   3.8e-12     3e-09       1      31 []      13      42 ..      13      42 .. 0.95
   2 !   20.2   0.3   4.8e-07   0.00038       2      27 ..      50      75 ..      49      77 .. 0.89
   3 !   36.6   0.1   2.6e-12     2e-09       1      31 []      86     115 ..      86     115 .. 0.96
   4 !   19.4   0.2   8.5e-07   0.00066       1      27 [.     122     148 ..     118     154 .. 0.88

  Alignments for each domain:
  == domain 1  score: 36.1 bits;  conditional E-value: 3.8e-12
   EF-hand_6  1 elreaFklfDkdgdGkidaeElrkalrkalg 31
                el++aF lfD+dgdGki++eEl ++l+ +lg
  EFC38759.1 13 ELKDAFSLFDQDGDGKISIEELGAVLK-KLG 42
                699************************.777 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 4.8e-07
   EF-hand_6  2 lreaFklfDkdgdGkidaeElrkalr 27
                l+  F   D+d++G+i +eE++k++ 
  EFC38759.1 50 LQLMFSDVDQDNNGTIEFEEFMKMME 75
                6668999*****************97 PP

  == domain 3  score: 36.6 bits;  conditional E-value: 2.6e-12
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalrkalg 31 
                 e+reaF+ fDk++dG+i++eEl+++++ +lg
  EFC38759.1  86 EIREAFRVFDKNNDGFISYEELKSMMS-SLG 115
                 79*************************.887 PP

  == domain 4  score: 19.4 bits;  conditional E-value: 8.5e-07
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalr 27 
                 el+e  ++ D+dg+G +d+eE+++++ 
  EFC38759.1 122 ELNEMIRQADRDGNGVVDFEEFKSIFM 148
                 577888999***************886 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.3   2.6e-06     0.002      27      52 ..      13      38 ..      11      41 .. 0.82
   2 !   35.2   1.0   1.1e-11   8.2e-09      13      53 ..      37      75 ..      32      76 .. 0.88
   3 !   23.5   0.5   4.7e-08   3.7e-05      24      52 ..      83     111 ..      83     112 .. 0.96
   4 !   45.8   0.7   5.3e-15   4.1e-12       3      50 ..     100     145 ..     100     149 .. 0.95

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.6e-06
   EF-hand_8 27 evdilfrefDtdgdGkisfeEFcvll 52
                e+ + f++fD+dgdGkis eE  ++l
  EFC38759.1 13 ELKDAFSLFDQDGDGKISIEELGAVL 38
                67788**************9976555 PP

  == domain 2  score: 35.2 bits;  conditional E-value: 1.1e-11
   EF-hand_8 13 ilrilglkkglseeevdilfrefDtdgdGkisfeEFcvlle 53
                 l++lg+    s+ee++ +f+ +D+d++G+i feEF+ ++e
  EFC38759.1 37 VLKKLGQC--PSAEELQLMFSDVDQDNNGTIEFEEFMKMME 75
                45778877..9****************************97 PP

  == domain 3  score: 23.5 bits;  conditional E-value: 4.7e-08
   EF-hand_8  24 seeevdilfrefDtdgdGkisfeEFcvll 52 
                 +e+e+++ fr fD ++dG is+eE   ++
  EFC38759.1  83 TEDEIREAFRVFDKNNDGFISYEELKSMM 111
                 69***********************9998 PP

  == domain 4  score: 45.8 bits;  conditional E-value: 5.3e-15
   EF-hand_8   3 gkItreelrrilrilglkkglseeevdilfrefDtdgdGkisfeEFcv 50 
                 g I+ eel++++++lg    l+++e+ +++r +D+dg+G+++feEF  
  EFC38759.1 100 GFISYEELKSMMSSLGET--LTDKELNEMIRQADRDGNGVVDFEEFKS 145
                 789*********999*99..**************************86 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.8   0.5   3.9e-11     3e-08       1      24 [.      14      37 ..      14      39 .. 0.93
   2 !   18.8   0.9     1e-06    0.0008       2      25 .]      51      74 ..      50      74 .. 0.90
   3 !   33.5   0.1   2.3e-11   1.8e-08       1      25 []      87     111 ..      87     111 .. 0.92
   4 !   23.1   0.4   4.5e-08   3.5e-05       1      24 [.     123     147 ..     123     148 .. 0.90

  Alignments for each domain:
  == domain 1  score: 32.8 bits;  conditional E-value: 3.9e-11
                HHHHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5  1 lkdtFqaiDlNgDGkIskeELktl 24
                lkd+F+ +D +gDGkIs+eEL ++
  EFC38759.1 14 LKDAFSLFDQDGDGKISIEELGAV 37
                799******************986 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 1e-06
                HHHHHHH-SS-SSCE-HHHHHHHH CS
   EF-hand_5  2 kdtFqaiDlNgDGkIskeELktlv 25
                + +F+ +D ++ G+I +eE+++++
  EFC38759.1 51 QLMFSDVDQDNNGTIEFEEFMKMM 74
                558******************987 PP

  == domain 3  score: 33.5 bits;  conditional E-value: 2.3e-11
                 HHHHHHHH-SS-SSCE-HHHHHHHH CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIskeELktlv 25 
                 ++++F+ +D+N+DG+Is eELk ++
  EFC38759.1  87 IREAFRVFDKNNDGFISYEELKSMM 111
                 5778******************986 PP

  == domain 4  score: 23.1 bits;  conditional E-value: 4.5e-08
                 HHHHHHHH-SS-SSCE-HHHHHH.H CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIskeELkt.l 24 
                 l+++ +++D +g G +++eE+k  +
  EFC38759.1 123 LNEMIRQADRDGNGVVDFEEFKSiF 147
                 68899****************9855 PP

>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.0   5.1e-09   3.9e-06       3      63 ..      17      75 ..      15      76 .. 0.96
   2 !   23.6   0.0     6e-08   4.7e-05       3      65 ..      90     150 ..      88     151 .. 0.95

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 5.1e-09
   EF-hand_9  3 vFevcDtqktGrVpvsrlidyLravtaqdpeeseLeelakelDPdgedasvdldtflrvmr 63
                 F+++D +  G++ + +l ++L++ ++  p+  eL+   + +D d++ ++++++ f ++m 
  EFC38759.1 17 AFSLFDQDGDGKISIEELGAVLKKLGQ-CPSAEELQLMFSDVDQDNN-GTIEFEEFMKMME 75
                5**************************.*******************.**********995 PP

  == domain 2  score: 23.6 bits;  conditional E-value: 6e-08
   EF-hand_9   3 vFevcDtqktGrVpvsrlidyLravtaqdpeeseLeelakelDPdgedasvdldtflrvmrew 65 
                  F+v+D +  G +   +l++++   ++ + ++ eL+e  +++D dg+ + vd++ f+ + ++ 
  EFC38759.1  90 AFRVFDKNNDGFISYEELKSMMSSLGE-TLTDKELNEMIRQADRDGN-GVVDFEEFKSIFMKD 150
                 5**************************.9******************.**********98865 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.1   2.6e-05      0.02      47     112 ..       5      72 ..       1      73 [. 0.81
   2 !   18.1   0.1   3.2e-06    0.0025      52     111 ..      83     144 ..      72     146 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.6e-05
  SPARC_Ca_bdg  47 knlkeckepvawkFsklDtnsdkvlsksELaplraplvklehC..ikpflescDadkdkkislkEwce 112
                   k +++ +++++  Fs +D++ d+ +s +EL ++ ++l +  +    + +++  D+d++++i+ +E+++
    EFC38759.1   5 KPQDQLVNELKDAFSLFDQDGDGKISIEELGAVLKKLGQCPSAeeLQLMFSDVDQDNNGTIEFEEFMK 72 
                   5667788899999******************999977554333226779999999999*******986 PP

  == domain 2  score: 18.1 bits;  conditional E-value: 3.2e-06
  SPARC_Ca_bdg  52 ckepvawkFsklDtnsdkvlsksELaplrapl..vklehCikpflescDadkdkkislkEwc 111
                   ++++++  F  +D+n+d+++s +EL+++ ++l    +++  +++++++D d ++ ++ +E+ 
    EFC38759.1  83 TEDEIREAFRVFDKNNDGFISYEELKSMMSSLgeTLTDKELNEMIRQADRDGNGVVDFEEFK 144
                   56778889**********************994344689999******************96 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.1     0.021        16      43      69 ..      12      38 ..       1      42 [. 0.73
   2 !    9.4   0.3    0.0012      0.96      44      69 ..      49      74 ..      36      76 .. 0.77
   3 !   17.0   0.5   5.3e-06    0.0042       8      70 ..      86     149 ..      80     153 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.021
   EF-hand_4 43 dklekiwdladidedgkldfeefciam 69
                ++l+  ++l d d dgk+  ee+  ++
  EFC38759.1 12 NELKDAFSLFDQDGDGKISIEELGAVL 38
                35777899**************87655 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0012
   EF-hand_4 44 klekiwdladidedgkldfeefciam 69
                +l+ +++  d d++g+++feef+ +m
  EFC38759.1 49 ELQLMFSDVDQDNNGTIEFEEFMKMM 74
                5666666667777899******9877 PP

  == domain 3  score: 17.0 bits;  conditional E-value: 5.3e-06
   EF-hand_4   8 eikkyweifsglkpednkltgdkvapvlkn..skleedklekiwdladidedgkldfeef.ciamr 70 
                 ei++ + +f   k++d  ++ +++ +++ +    l++++l+++   ad d +g +dfeef  i m+
  EFC38759.1  86 EIREAFRVFD--KNNDGFISYEELKSMMSSlgETLTDKELNEMIRQADRDGNGVVDFEEFkSIFMK 149
                 5666666665..6778899999999999863368**************************457776 PP

>> Caleosin  Caleosin related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.029        22       6      34 ..      14      42 ..      11      46 .. 0.74
   2 !   11.2   0.2   0.00034      0.26      93     128 ..      48      83 ..      45      91 .. 0.89
   3 ?    5.4   0.0      0.02        15      11      34 ..      92     115 ..      84     120 .. 0.69

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.029
    Caleosin  6 LqqHvaFfDrdkdGiiypldtyrgfralg 34
                L+  ++ fD+d dG i   +    +++lg
  EFC38759.1 14 LKDAFSLFDQDGDGKISIEELGAVLKKLG 42
                55556789999999999888766666665 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00034
    Caleosin  93 qkfeeifskyakekkdaltlkevlellkgqrealDl 128
                 ++++ +fs  +++++++++++e++++++g r+ +D+
  EFC38759.1  48 EELQLMFSDVDQDNNGTIEFEEFMKMMEGGRNNVDT 83 
                 567789**************************9996 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.02
    Caleosin  11 aFfDrdkdGiiypldtyrgfralg 34 
                   fD+++dG+i   +  + + +lg
  EFC38759.1  92 RVFDKNNDGFISYEELKSMMSSLG 115
                 458888888888777666555555 PP

>> UPF0154  Uncharacterised protein family (UPF0154)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.33   2.6e+02      34      57 ..      33      56 ..      27      59 .. 0.76
   2 !   15.6   0.1   1.5e-05     0.012      30      58 ..     102     130 ..      92     132 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.33
     UPF0154 34 mirammkqmGrkPSekqikqvmrs 57
                 + a +k+ G+ PS   ++ +   
  EFC38759.1 33 ELGAVLKKLGQCPSAEELQLMFSD 56
                566778999*****9999988765 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 1.5e-05
     UPF0154  30 inekmirammkqmGrkPSekqikqvmrsm 58 
                 i+ + ++ mm++ G +++ k +++++r+ 
  EFC38759.1 102 ISYEELKSMMSSLGETLTDKELNEMIRQA 130
                 88899*********************985 PP

>> EF-hand_14  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0    0.0046       3.6       6      48 ..      18      60 ..      14      78 .. 0.82
   2 !    9.4   0.1    0.0017       1.3       6      45 ..      91     130 ..      83     152 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0046
  EF-hand_14  6 fdlfkdeetdklsvakllkaLaetGirkdDpRLkellkklkkv 48
                f lf++++++k+s+++l ++L++ G + +   L+ +++ + + 
  EFC38759.1 18 FSLFDQDGDGKISIEELGAVLKKLGQCPSAEELQLMFSDVDQD 60
                99***********************888777777777776655 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0017
  EF-hand_14   6 fdlfkdeetdklsvakllkaLaetGirkdDpRLkellkkl 45 
                 f +f++++++ +s ++l +++++ G + +D  L+e++++ 
  EFC38759.1  91 FRVFDKNNDGFISYEELKSMMSSLGETLTDKELNEMIRQA 130
                 8899999*****************************9985 PP

>> EF-hand_11  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0     0.025        20      25      83 ..      17      75 ..      10      85 .. 0.89
   2 !    9.9   0.1    0.0017       1.3      22      85 ..      87     150 ..      79     156 .] 0.90

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.025
                HHHHH-TT-SSEE-HHHHHHHHHHHT----HHHHHHHHHTS-B-TTS-EEHHHHHHHHC CS
  EF-hand_11 25 efenfdtlksntvsreefraictrrvqiltdeqfdrlwselpvnakgrlkyqdflskls 83
                 f  fd      +s ee+ a+ ++  q  + e+++ ++s++  + +g + +++f+  + 
  EFC38759.1 17 AFSLFDQDGDGKISIEELGAVLKKLGQCPSAEELQLMFSDVDQDNNGTIEFEEFMKMME 75
                577788888899******************************************98765 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0017
                 HHHHHHHH-TT-SSEE-HHHHHHHHHHHT----HHHHHHHHHTS-B-TTS-EEHHHHHHHHCS- CS
  EF-hand_11  22 ivqefenfdtlksntvsreefraictrrvqiltdeqfdrlwselpvnakgrlkyqdflsklsie 85 
                 i + f  fd  +   +s ee++++ +   + ltd++++ +  +   + +g + +++f s +  +
  EFC38759.1  87 IREAFRVFDKNNDGFISYEELKSMMSSLGETLTDKELNEMIRQADRDGNGVVDFEEFKSIFMKD 150
                 6678999**99999*******************************************9988766 PP

>> DUF2666  Protein of unknown function (DUF2666)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0     0.034        26      53      95 ..      11      53 ..       6      75 .. 0.82
   2 ?    7.8   0.1    0.0045       3.5      54      98 ..      85     129 ..      72     148 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.034
                HHHHHHHTTT--S--S....HHHHHHHHHHHHT-......... CS
     DUF2666 53 lekleeiadeikkkkkgrvkeedisevleklkspattkklnki 95
                +++l++ ++ + +   g++  e++  vl+kl +  +++ l+ +
  EFC38759.1 11 VNELKDAFSLFDQDGDGKISIEELGAVLKKLGQCPSAEELQLM 53
                5789999999*********************988777766644 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0045
                 HHHHHHTTT--S--S....HHHHHHHHHHHHT-............ CS
     DUF2666  54 ekleeiadeikkkkkgrvkeedisevleklkspattkklnkitds 98 
                 ++++e +  + k+  g +  e+++ +++ l +  t k ln++  +
  EFC38759.1  85 DEIREAFRVFDKNNDGFISYEELKSMMSSLGETLTDKELNEMIRQ 129
                 579*************************************98654 PP

>> p25-alpha  p25-alpha
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.2   0.00094      0.73      43      73 ..      49      79 ..      16     121 .. 0.86
   2 ?    1.4   0.0       0.4   3.1e+02      47      75 ..      90     118 ..      80     138 .. 0.74
   3 ?   -1.1   0.0       2.4   1.8e+03      49      70 ..     128     150 ..     112     154 .. 0.62

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00094
   p25-alpha 43 dvDiiFsKvkaksarkitfeqfkealeelae 73
                +  ++Fs v + ++ +i+fe+f++++e   +
  EFC38759.1 49 ELQLMFSDVDQDNNGTIEFEEFMKMMEGGRN 79
                66799********************997555 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.4
   p25-alpha  47 iFsKvkaksarkitfeqfkealeelaekk 75 
                 +F+ + ++++  i++e+ k +++ l e  
  EFC38759.1  90 AFRVFDKNNDGFISYEELKSMMSSLGETL 118
                 57767777889999999999999998882 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 2.4
   p25-alpha  49 sKvkaksarkitfeqfke.alee 70 
                 ++    ++  ++fe+fk  ++++
  EFC38759.1 128 RQADRDGNGVVDFEEFKSiFMKD 150
                 45555667778888888755555 PP

>> SurA_N_2  SurA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.5   0.00011     0.083      48     143 ..      62     145 ..      53     147 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 0.00011
    SurA_N_2  48 GekIslqefqqaveearqqlqqqlgenfdeseedeaqlreqvldqlvseklleqeaeklGltvsdeelqdaiqgnpaikqsFqpetGkFdkeklkq 143
                 + +I+++ef +++e  r+++  +  ++      +  ++ ++  d ++s + l+  + +lG t +d+el+++i++         + +G++d e++k+
  EFC38759.1  62 NGTIEFEEFMKMMEGGRNNVDTE--DE----IREAFRVFDKNNDGFISYEELKSMMSSLGETLTDKELNEMIRQADR------DGNGVVDFEEFKS 145
                 55788888888888888865543..22....23346788888999*****************************777......5777777777765 PP

>> EFhand_Ca_insen  Ca2+ insensitive EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       9.8   7.6e+03      52      65 ..      59      72 ..      47      74 .. 0.62
   2 ?   12.9   0.2   0.00012      0.09       1      31 [.      80     111 ..      80     149 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 9.8
                     .S-TTEEECCCHTT CS
  EFhand_Ca_insen 52 davekayDYvsFle 65
                     + +++   +++F++
       EFC38759.1 59 QDNNGTIEFEEFMK 72
                     44555566777776 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 0.00012
                      G-STHHHHHCHHHHH.CTTSSSEEHHHHHHH- CS
  EFhand_Ca_insen   1 dvdsaeqveeaFral.aggKpYvTeedLrrel 31 
                      +vd+ ++++eaFr   +++  ++  e+L+  +
       EFC38759.1  80 NVDTEDEIREAFRVFdKNNDGFISYEELKSMM 111
                      799************888889*******9654 PP

>> TerB  Tellurite resistance protein TerB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       1.8   1.4e+03      66      93 ..      13      40 ..       7      55 .. 0.60
   2 ?    0.7   0.0      0.59   4.6e+02      41      92 ..      26      75 ..      23      93 .. 0.62
   3 ?    9.4   0.0    0.0012      0.93      41      94 ..      99     150 ..      97     155 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.8
        TerB 66 eakallelfeeaeeeavdleqftralkr 93
                e+k+++ lf++  + +++ e+  + lk+
  EFC38759.1 13 ELKDAFSLFDQDGDGKISIEELGAVLKK 40
                5566666666666667777766666655 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.59
        TerB 41 DgqvsesErqafrellksrfglspeeakallelfeeaeeeavdleqftralk 92
                Dg++s +E  a+ + l +    s+ee++  +   ++  + ++++e+f + + 
  EFC38759.1 26 DGKISIEELGAVLKKLGQCP--SAEELQLMFSDVDQDNNGTIEFEEFMKMME 75
                56666666665555552222..345555555666666666888888887665 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.0012
        TerB  41 DgqvsesErqafrellksrfglspeeakallelfeeaeeeavdleqftralkrk 94 
                 Dg +s +E + +++ l     l+++e+++ ++++++  + +vd+e+f + + + 
  EFC38759.1  99 DGFISYEELKSMMSSL--GETLTDKELNEMIRQADRDGNGVVDFEEFKSIFMKD 150
                 8889999999999999..77788************************8877665 PP

>> DUF4497  Protein of unknown function (DUF4497)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.046        36      67      94 ..       6      31 ..       1      44 [. 0.68
   2 ?    6.2   0.0     0.018        14      54     106 ..      66     119 ..      48     120 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.046
     DUF4497 67 knepvsktikgtfpLkdedgqtvGeisl 94
                 ++ ++  +k+ f L+d+dg+  G+is+
  EFC38759.1  6 PQDQLVNELKDAFSLFDQDGD--GKISI 31
                45566899*************..55544 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.018
     DUF4497  54 lfnklikevkekkknepvsktikgtfpLkdedgq.tvGeislylRlsclGksii 106
                 +f++++k+++  ++n  + + i+  f+++d++++  +   +l   +s+lG++++
  EFC38759.1  66 EFEEFMKMMEGGRNNVDTEDEIREAFRVFDKNNDgFISYEELKSMMSSLGETLT 119
                 5788899999999999999***************9999999*********9885 PP

>> SUB1_ProdP9  SUB1 protease Prodomain ProdP9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.92   7.2e+02      33      65 ..      42      75 ..       7      89 .. 0.70
   2 ?   10.7   0.2   0.00047      0.36      39      69 ..     105     135 ..      93     143 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.92
  SUB1_ProdP9 33 Gklanlknlksiiielkedtt.deelieyikile 65
                 G+     +l+ +  ++++d     e+ e++k++e
   EFC38759.1 42 GQCPSAEELQLMFSDVDQDNNgTIEFEEFMKMME 75
                 4444455566666666665541347777777777 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00047
  SUB1_ProdP9  39 knlksiiielkedttdeelieyikileekGa 69 
                   +lks++  l e +td+el e i+  ++ G 
   EFC38759.1 105 EELKSMMSSLGETLTDKELNEMIRQADRDGN 135
                  689********************99998875 PP

>> Glyco_hydro_56  Hyaluronidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   0.00033      0.26      86     120 ..     119     153 ..     108     155 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00033
                     HHHHHHHH---TT--SEEEE---SS-SSGGG--GG CS
  Glyco_hydro_56  86 akediekaipekdfkGlavidweeWrPlwerNwgs 120
                     ++++++++i+++d +G +v+d+ee + ++ ++++s
      EFC38759.1 119 TDKELNEMIRQADRDGNGVVDFEEFKSIFMKDISS 153
                     57899**********************99988765 PP

>> EF-hand_10  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.4     0.028        22      25      48 ..      52      72 ..      28      75 .. 0.75
   2 ?    4.2   0.3     0.052        41      15      48 ..      80     112 ..      79     114 .. 0.75
   3 ?    8.4   0.4    0.0025         2       2      45 ..     102     145 ..     101     150 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.028
  EF-hand_10 25 kLFkkcDkSksgrLegeEieeFyk 48
                 +F   D+ ++g++e eE+    k
  EFC38759.1 52 LMFSDVDQDNNGTIEFEEFM---K 72
                47999999999998766654...4 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.052
  EF-hand_10  15 NievddeYAekLFkkcDkSksgrLegeEieeFyk 48 
                 N++ +de  ++ F+  Dk ++g++  eE++  + 
  EFC38759.1  80 NVDTEDEI-REAFRVFDKNNDGFISYEELKSMMS 112
                 66666663.6779999999999999999987655 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0025
  EF-hand_10   2 msfkEvkrlLreiNievddeYAekLFkkcDkSksgrLegeEiee 45 
                 +s++E+k+++  +   + d+  +++ +++D+  +g  + eE++ 
  EFC38759.1 102 ISYEELKSMMSSLGETLTDKELNEMIRQADRDGNGVVDFEEFKS 145
                 59***************************************985 PP

>> Mst1_SARAH  C terminal SARAH domain of Mst1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       9.7   7.6e+03       9      21 ..      11      23 ..      10      24 .. 0.78
   2 ?   -1.0   0.0       2.5   1.9e+03       7      19 ..      29      41 ..      27      44 .. 0.82
   3 ?    0.8   0.1      0.67   5.2e+02       8      22 ..      46      60 ..      37      67 .. 0.85
   4 ?    8.9   0.2     0.002       1.6       6      30 ..     101     126 ..     100     130 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 9.7
  Mst1_SARAH  9 vdeLqqrlasLDp 21
                v+eL++ ++  D+
  EFC38759.1 11 VNELKDAFSLFDQ 23
                5799998888886 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.5
  Mst1_SARAH  7 lsvdeLqqrlasL 19
                +s++eL   l++L
  EFC38759.1 29 ISIEELGAVLKKL 41
                7999999988887 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.67
  Mst1_SARAH  8 svdeLqqrlasLDpe 22
                s++eLq  ++  D++
  EFC38759.1 46 SAEELQLMFSDVDQD 60
                899****99999985 PP

  == domain 4  score: 8.9 bits;  conditional E-value: 0.002
  Mst1_SARAH   6 flsvdeLqqrlasLDpeM.EqEieel 30 
                 f+s++eL+  ++sL + + ++E++e+
  EFC38759.1 101 FISYEELKSMMSSLGETLtDKELNEM 126
                 79************988767888875 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   3.6    0.0027       2.1      72      99 .]      80     108 ..      29     108 .. 0.77
   2 ?    1.6   0.1       0.7   5.4e+02      88      99 .]     133     144 ..     113     144 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0027
     DUF4834  72 eersekeakrk.kiFekdeGEYVdFEEvk 99 
                 + ++e+e+++  ++F+k+++ ++ +EE k
  EFC38759.1  80 NVDTEDEIREAfRVFDKNNDGFISYEELK 108
                 3344555667779**************87 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.7
     DUF4834  88 deGEYVdFEEvk 99 
                 d    VdFEE k
  EFC38759.1 133 DGNGVVDFEEFK 144
                 555679****87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       920  (0.0513135); expected 358.6 (0.02)
Passed bias filter:                      672  (0.0374812); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              23  [number of targets reported over threshold]
# CPU time: 0.58u 0.35s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 944.95
//
Query:       EFC38760.1  [L=116]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-18   65.8   0.4    4.8e-18   65.4   0.4    1.1  1  SUI1      Translation initiation factor SUI1


Domain annotation for each model (and alignments):
>> SUI1  Translation initiation factor SUI1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.4   0.4   2.7e-22   4.8e-18       2      75 ..      22      95 ..      21      97 .. 0.92

  Alignments for each domain:
  == domain 1  score: 65.4 bits;  conditional E-value: 2.7e-22
        SUI1  2 kpkihirleqrggrKkvTtvsgleafgidlkklakelkkkfacsgsvvkdg..geeiqvQGdqrkkvaelLtekyg 75
                 +kih+r+ +r+++Kk+Tt++gl +++i lk+l k+l + f cs+ vv+d+  g+ i++QGdqr +v++++  + +
  EFC38760.1 22 ISKIHVRIFSRSNNKKITTIEGL-SQNIPLKTLTKTLSSLFECSAIVVDDEerGKIITLQGDQRMNVVQYMLRE-N 95
                589********************.99***********************774459***************9887.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       447  (0.0249317); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.25s 00:00:00.72 Elapsed: 00:00:00.46
# Mc/sec: 753.92
//
Query:       EFC38761.1  [L=304]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.024   14.4   0.2      0.061   13.1   0.2    1.6  1  DUF4534   Protein of unknown function (DUF4534)
      0.036   14.0   0.1      0.036   14.0   0.1    2.1  3  Syndecan  Syndecan domain


Domain annotation for each model (and alignments):
>> DUF4534  Protein of unknown function (DUF4534)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.2   6.8e-06     0.061       9      81 ..     179     253 ..     177     256 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 6.8e-06
     DUF4534   9 GvFsilatilflifelkeltkinyedkssiyketksevssfiicyskkivillsli..TilvscllLysvyaqiy 81 
                 G+ ++ + +++ if +k    ++y+ +++  +++++  +  i     + +i+ls+i  T+l++ l+L++v ++  
  EFC38761.1 179 GILTLNSNQQYSIFYQKSNLISQYTPSVTFRTNSNQYDKCLIDQSAINAAIILSVIggTFLLTGLILFCVLRNRK 253
                 88899999*****************9888888777666666667778999*****9999***********98865 PP

>> Syndecan  Syndecan domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.7   1.7         2   1.8e+04      22      30 ..       7      15 ..       3      19 .. 0.45
   2 ?   -3.6   0.0       1.2   1.1e+04      43      56 ..     182     195 ..     179     197 .. 0.72
   3 ?   14.0   0.1   4.1e-06     0.036       2      36 ..     219     253 ..     218     259 .. 0.92

  Alignments for each domain:
  == domain 1  score: -4.7 bits;  conditional E-value: 2
    Syndecan 22 faillvlfl 30
                +  +l+++l
  EFC38761.1  7 LSAFLIALL 15
                333344333 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 1.2
    Syndecan  43 aLdepkksnaaYkk 56 
                 +L+ +++++  Y+k
  EFC38761.1 182 TLNSNQQYSIFYQK 195
                 57788888888965 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 4.1e-06
    Syndecan   2 llerpevlaaviggvvvgllfaillvlflvYRmrK 36 
                 l++++ + aa+i +v+ g  ++  l+lf+v R rK
  EFC38761.1 219 LIDQSAINAAIILSVIGGTFLLTGLILFCVLRNRK 253
                 678999**************************999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       781  (0.0435607); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.26s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1909.32
//
Query:       EFC38762.1  [L=131]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.5e-07   29.5   0.1    8.9e-07   29.3   0.1    1.1  1  PIN_4     PIN domain


Domain annotation for each model (and alignments):
>> PIN_4  PIN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   0.1     5e-11   8.9e-07      23     127 ..      19     120 ..       8     124 .. 0.76

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 5e-11
       PIN_4  23 dvviPitVleELdklKkgsserelarlarqanrlldel..lekesgrlkvqtsaeelpee.eseseknDnrIlavalelkeekp.drkvvLvskDinlr 117
                  v+ P  Vl ELd+lK+++    l++++   +++ d+l  l+++++   vq+    + +     + + D++I+ +a +lke+   +++v L+s+D  + 
  EFC38762.1  19 LVCFPRRVLIELDGLKNDNA---LRKKIVALQQITDSLgsLRHNEPVEDVQKY---IRSMlV-GDITWDEEIILTAKYLKENVCiNNNVKLLSNDYGVH 110
                 5899***************7...888877777766666334444445555554...444322.24689************98766**********9999 PP

       PIN_4 118 ikAkalgiea 127
                 +  ++ ++++
  EFC38762.1 111 TLSNTYDVQV 120
                 9888888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       627  (0.0349713); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.28s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 903.00
//
Query:       EFC38763.1  [L=1628]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-45  153.8   0.1    6.3e-45  153.0   0.1    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    4.1e-12   46.3   0.0    4.6e-11   42.9   0.0    2.6  2  PAS_9          PAS domain
    0.00019   21.4   0.0    0.00044   20.2   0.0    1.6  1  PAS            PAS fold
    0.00048   20.3   0.0      0.001   19.3   0.0    1.5  1  PAS_4          PAS fold
  ------ inclusion threshold ------
      0.013   14.9   0.5      0.013   14.9   0.5    1.8  2  HNOBA          Heme NO binding associated
       0.22   11.7   5.6        2.5    8.3   5.6    2.7  1  DUF3546        Domain of unknown function (DUF3546)


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.0   0.1   2.1e-48   6.3e-45       4     180 ..    1404    1579 ..    1401    1582 .. 0.96

  Alignments for each domain:
  == domain 1  score: 153.0 bits;  conditional E-value: 2.1e-48
  Guanylate_cyc    4 esydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp...eekaahaaklaelaLdmlealeevav 94  
                      ++d+vtilF+dIvg  +l    s++++v+ Lne++ +fd+l+ + +++k+ktiG++y +++gl+    ++a+h+++ + +a ++ e ++ +++
     EFC38763.1 1404 DKFDDVTILFSDIVGLLDLNL--SAFDLVQTLNEIIHEFDDLTINFNLEKIKTIGSKYFCTAGLKpdgMNEAHHVERTFTFAVKLSEVVQLFCE 1495
                     689************988866..78****************************************99999************************ PP

  Guanylate_cyc   95 eskeglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyf 180 
                     ++  ++ +rvGi++Gp+vagv G  k  ydvw+++vn+Asrmest  ag iqv+e+ y+ lk ++ e++er  vevkGkg+++ty+
     EFC38763.1 1496 DHGLNIGIRVGINSGPIVAGVCGVLKYAYDVWSDAVNTASRMESTCPAGFIQVTETCYQRLK-DKHEFQER-YVEVKGKGQMKTYI 1579
                     **************************************************************.88899887.69***********8 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.42   1.3e+03      41      85 ..     686     728 ..     661     739 .. 0.72
   2 !   42.9   0.0   1.5e-14   4.6e-11       4     104 .]    1264    1364 ..    1261    1364 .. 0.95

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.42
       PAS_9  41 vtdpeanerlraaleqgrkkerevevvlirkngetfwvlltaspv 85 
                 v++++ +e +++a +q +  +++  ++  ++n++tf++ ++   v
  EFC38763.1 686 VSEQQPEELMDQADKQQE--VFSSALHKKDENRTTFYFIVSSGLV 728
                 666677777777777777..9999999999999999988887665 PP

  == domain 2  score: 42.9 bits;  conditional E-value: 1.5e-14
       PAS_9    4 ilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk....kerevevvlirkngetfwvlltaspvkdddgelvgii 96  
                   +i+ ++g+i  +N+a ++l+G+  ++++g +++ lf  d+e++ +l+ ++  +        ++ e+   rkn + f+v+l++s    +++++++  
  EFC38763.1 1264 AVICSSSGTIDIFNNASEKLFGFRGDQIIGFPLHKLF--DKESAANLEPVISKMGVsatsYSETLELNGLRKNSSSFPVELRISVSALEGRNIIS-- 1356
                  46788********************************..999999999999999999***99******************999999889******.. PP

       PAS_9   97 vilrDite 104 
                  +++rDi+e
  EFC38763.1 1357 CFMRDISE 1364
                  ******98 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.5e-07   0.00044       4     113 .]    1254    1362 ..    1252    1362 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.5e-07
                  HHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHH.HHHHHHHHHHHHTT-ECCCCEEEECTTSSEEEEEEEEEEEEET CS
         PAS    4 raileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheedda.elaelleqlleqgeesrageisfklrdgrpihlevraspvrda 99  
                  raile++ +  ++   +g i  +N a e+l+G++ ++++g +l  l+  e+ a   + + +   ++++ s++ e +  +++ + +++e+r s    +
  EFC38763.1 1254 RAILEAALTSAVICSSSGTIDIFNNASEKLFGFRGDQIIGFPLHKLFDKESAAnLEPVISKMGVSATSYSETLELNGLRKNSSSFPVELRISVSALE 1350
                  789999878888888********************************999777555555555555555566666655559***************** PP

                  TEEEEEEEEEEEES CS
         PAS  100 ggeilgflgvlrdi 113 
                  g +   + +++rdi
  EFC38763.1 1351 GRN--IISCFMRDI 1362
                  **9..6******98 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   3.5e-07     0.001       9     108 ..    1265    1365 ..    1258    1367 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 3.5e-07
       PAS_4    9 avldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvlegeepiefleelll...pgeerhyelrllPlrdesGevigvlvis 102 
                  +++++ g++   N+a+++lfg+++++++G +l+ l+ +e+aa+le+ + ++  + ++++++ el+    + +  ++elr++   + +G+   + +++
  EFC38763.1 1265 VICSSSGTIDIFNNASEKLFGFRGDQIIGFPLHKLFDKESAANLEPVISKMGVSATSYSETLELNGlrkNSSSFPVELRISVS-ALEGR-NIISCFM 1359
                  577999********************************************************999998877777888877544.56788.7788999 PP

       PAS_4  103 rDiTer 108 
                  rDi+e 
  EFC38763.1 1360 RDISEH 1365
                  999885 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   0.5       3.6   1.1e+04     101     122 ..     627     648 ..     588     664 .. 0.51
   2 ?   14.9   0.5   4.3e-06     0.013     194     221 .]    1368    1395 ..    1359    1395 .. 0.91

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 3.6
       HNOBA 101 dlkekkredrnvkksrslkLkG 122
                 ++++++++++n++++rs k +G
  EFC38763.1 627 SSQHSSSNNNNSDNERSDKTHG 648
                 1222222223334444444444 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 4.3e-06
       HNOBA  194 smkeleeekkrtdeLLysmiPkevAerL 221 
                  + kel eekk++++LL +++P++vA+rL
  EFC38763.1 1368 QVKELAEEKKKSESLLMNIMPESVAQRL 1395
                  6799**********************98 PP

>> DUF3546  Domain of unknown function (DUF3546)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   5.6   0.00085       2.5       5     100 ..     600     700 ..     597     705 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00085
     DUF3546   5 esqedeiekeeaqkkYdeYkeefqkkqleeFfe.aHkdeeWfr.ekYhPeelak...rkeelrellkkrlevFlellesgvfdevsleadnskeevkll 98 
                 +   d+ e++ +qk++ +Y+eef+ k   +    ++ +++  r +k h e +     + + ++++   r++ F+e+++++ fd++s+++++++e+++ +
  EFC38763.1 600 NLLIDNEEDHAIQKMFAQYQEEFKFKPSSQHSSsNNNNSDNERsDKTHGELIITksyTSSSSNNNNGMRVDMFSENVNDEAFDSISVSEQQPEELMDQA 698
                 5556999*****************998877765144555566526889987655111445666777789*******************99999766555 PP

     DUF3546  99 da 100
                 d+
  EFC38763.1 699 DK 700
                 54 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1628 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1376  (0.0767472); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.09u 0.31s 00:00:01.40 Elapsed: 00:00:00.49
# Mc/sec: 10034.70
//
Query:       EFC38764.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0064   15.4   1.7      0.007   15.2   1.7    1.0  1  YqfD          Putative stage IV sporulation protein YqfD
  ------ inclusion threshold ------
        0.6   10.8   7.7       0.35   11.6   3.8    2.1  2  COMPASS-Shg1  COMPASS (Complex proteins associated with Set1p


Domain annotation for each model (and alignments):
>> YqfD  Putative stage IV sporulation protein YqfD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   1.7   7.8e-07     0.007     227     346 ..      17     137 ..       7     164 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 7.8e-07
        YqfD 227 kegktryvhAkGeV.iarvwyeaevevpleeekkeetgkkkkkyylkiggkkiplkg.kkspfekydkieeekklk.llrnfrlPveivketyreyeek 322
                 k +++ +  ++G++ +a+   ++  e+  e + ++ +g+++++++++++gk+i  +   k++ ++y+k+e+ k l+ ll++  lP  ++ke+  + +++
  EFC38764.1  17 KVDHKAVLSSDGHIhYANNSLDSITEFCNEVTDYKTSGQVADRIKFSLNGKEIGEYSdFKEKVQDYHKKEKLKALHcLLSGSPLPTIVKKEK--KEKKE 113
                 56666677777777667777788888888999999******************999989999999*88888888652455555555444444..44455 PP

        YqfD 323 eeelteeeakeeaeekaeeelkkk 346
                   e t++ +k+++++  + +l++k
  EFC38764.1 114 SSESTQDSVKQILKQFKKLSLEDK 137
                 556677777777777666666665 PP

>> COMPASS-Shg1  COMPASS (Complex proteins associated with Set1p) component shg1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1      0.11     1e+03      53      82 ..      51      82 ..      34      92 .. 0.59
   2 ?   11.6   3.8   3.9e-05      0.35      24      86 ..     106     166 ..     103     167 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.11
  COMPASS-Shg1 53 knrgkaaaliegeidrs..dvykkleegvdri 82
                  k  g++a+ i+ +++ +  + y++ +e+v+ +
    EFC38764.1 51 KTSGQVADRIKFSLNGKeiGEYSDFKEKVQDY 82
                  44555555555555544444444444444444 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 3.9e-05
  COMPASS-Shg1  24 keseaeqnlrkkveeivesevkkdpsllfknrgkaaaliegeidrsdvykkleegvdrivdqd 86 
                   ke++++++  ++ ++ v++ +k+ ++l ++++g   +l+ ++ +++  +++ +++vd+++d+d
    EFC38764.1 106 KEKKEKKESSESTQDSVKQILKQFKKLSLEDKGRCMKLLMSQFVEQ--VNEESNDVDNTIDSD 166
                   577888999999*********************************6..444679999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2761  (0.153996); expected 358.6 (0.02)
Passed bias filter:                     1005  (0.0560544); expected 358.6 (0.02)
Passed Vit filter:                        84  (0.00468515); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.46u 0.23s 00:00:00.69 Elapsed: 00:00:00.39
# Mc/sec: 1279.26
//
Query:       EFC38765.1  [L=329]
Description: hypothetical protein NAEGRDRAFT_81521 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-10   40.6   0.0    4.6e-08   32.8   0.0    2.3  2  UQ_con    Ubiquitin-conjugating enzyme


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.0   0.00066        12       2      33 ..     170     202 ..     169     209 .. 0.81
   2 !   32.8   0.0   2.6e-12   4.6e-08      48     108 ..     231     294 ..     224     325 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.00066
                 HHHHHH..HHHHSTTTTEEEEEEETTEECEEEEE CS
      UQ_con   2 lqkelk..elakkkpsgisaklvddenlfewkvl 33 
                 ++ke++  + a++++ gisa++v+d +lf+w++ 
  EFC38765.1 170 IMKEYMkiKQANTEKFGISANPVND-DLFHWEIR 202
                 6899995555677888999*****7.*****986 PP

  == domain 2  score: 32.8 bits;  conditional E-value: 2.6e-12
                 EEEEE--TTTTTS--EEEESST-S...CTTBETTSBB-CGGGSTTT--TTSHHHHHHHHHHHHH CS
      UQ_con  48 klelefpedYPlkpPkvkfvtkif...HPnvdksGevcldiLkeekWspaltlesvllsiqsLl 108
                 +l+l+fp ++P+kpP ++  ++ f     +v   G++c+++L ++ Ws++ +les++++i s +
  EFC38765.1 231 TLDLTFPLEFPFKPPFIRVLKPRFafrTGHVTIGGSICMELLTSSGWSSVCSLESIFVQIRSEM 294
                 689*****************965522267999**************************998743 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       752  (0.0419432); expected 358.6 (0.02)
Passed bias filter:                      605  (0.0337442); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.36s 00:00:01.06 Elapsed: 00:00:00.59
# Mc/sec: 1693.98
//
Query:       EFC38766.1  [L=101]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.016   15.3   0.6       0.02   15.0   0.6    1.2  1  P5-ATPase  P5-type ATPase cation transporter


Domain annotation for each model (and alignments):
>> P5-ATPase  P5-type ATPase cation transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.6   1.1e-06      0.02      38     117 ..       3      82 ..       3      99 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.1e-06
   P5-ATPase  38 lPewrvkltgkpcpLkeadvvliedefgelsvkkvrkleyerplstvfsseqeegeekeieskeseekdpelqqlryfdy 117
                 +P+ ++k++++++pL+   vv +  + +++s + ++k+  e+pl ++ +++ e++++ +   k +e +d++l+q+   +y
  EFC38766.1   3 KPKTWMKVVTVAAPLSVIGVVFLSLQINKWSKQWLDKKANENPLYSIYKENVERTNQGKPIIKPEEIQDEQLRQVYQAEY 82 
                 699********************************************966555555444334445555666666655544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (101 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1538  (0.0857828); expected 358.6 (0.02)
Passed bias filter:                      624  (0.0348039); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.36s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 558.34
//
Query:       EFC38767.1  [L=454]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (454 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       413  (0.0230353); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                         8  (0.000446204); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2664.23
//
Query:       EFC38768.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0017   18.1   0.2     0.0023   17.7   0.2    1.2  1  Tetraspanin  Tetraspanin family
     0.0022   18.0   0.4     0.0041   17.1   0.4    1.4  1  DUF3561      Protein of unknown function (DUF3561)
  ------ inclusion threshold ------
      0.011   15.9   1.3       0.02   15.0   1.3    1.4  1  Pox_A14      Poxvirus virion envelope protein A14
      0.012   15.8   1.0      0.026   14.7   1.0    1.5  1  PITH         PITH domain
      0.018   15.1   1.2      0.029   14.4   0.3    1.7  2  POC3_POC4    20S proteasome chaperone assembly proteins 3 and
      0.031   14.0   0.6       0.05   13.3   0.6    1.4  1  NEMP         NEMP family
      0.052   12.3   2.6      0.069   11.9   2.5    1.4  1  DUF2207      Predicted membrane protein (DUF2207)
      0.057   13.4   0.6      0.084   12.9   0.6    1.3  1  CRPA         Chlamydia 15 kDa cysteine-rich outer membrane pr
       0.18   11.6   0.1       0.18   11.6   0.1    2.0  1  Vpu          Vpu protein
          2    8.7   6.5       0.72   10.1   0.6    2.6  3  Pro_sub2     Prodomain subtilisin 2
        5.8    6.8   5.8        1.2    9.0   1.9    1.8  2  DUF2721      Protein of unknown function (DUF2721)


Domain annotation for each model (and alignments):
>> Tetraspanin  Tetraspanin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.2   1.4e-06    0.0023      43     139 ..     111     238 ..      96     241 .. 0.78

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 1.4e-06
                  ..........XXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--HHH................................. CS
                  xxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........................xxxxxxxx RF
  Tetraspanin  43 aedpailaillivvGv.llfllgflGcigalkenkcllltfsllllvlfllelaagilgfvfsdk.........................argkvsei 114
                   ++ + ++ + +vvGv +l++++++ +i  + +    l+ f++ + +++ + +++g+l+++++ k                         ++ ++++ 
   EFC38768.1 111 VSKLDKYYSVGVVVGVvILCVISLCLVIPLIVDMDNSLVYFLIAIPFVLGIGIVVGVLFYFLRRKivnnhsiceaeiervlrveeerireSNAEYESF 208
                  4444455567899999899**********************************************999888888888888888888888755556666 PP

                  HHHHHHHHHHHHHHHHHH.T....HHHHHH CS
                  xxxxxxxxxxxxxxxxxx.x....xxxxxx RF
  Tetraspanin 115 innaievkyrddldlkkc.q....nlldsl 139
                  ++++ +v+++ +ld+++  +    n++++l
   EFC38768.1 209 FKDSERVNVKLQLDYPNIrRislkNTWKFL 238
                  666666666666666544335555666665 PP

>> DUF3561  Protein of unknown function (DUF3561)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.4   2.5e-06    0.0041      22      86 ..     116     179 ..      97     192 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 2.5e-06
     DUF3561  22 tyslsGavvGfvsy...llalaiPfllyGsntlffllytWPfflallPvsvlvGvalsvllrgkllys 86 
                 +y  +G vvG v+     l l iP+++   n+l ++l + Pf l    + ++vGv + +l r+k++  
  EFC38768.1 116 KYYSVGVVVGVVILcviSLCLVIPLIVDMDNSLVYFLIAIPFVLG---IGIVVGVLFYFL-RRKIVNN 179
                 4556788888765411157899********************875...799999987655.5555544 PP

>> Pox_A14  Poxvirus virion envelope protein A14
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   1.3   1.2e-05      0.02       6      70 ..     113     175 ..     108     204 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.2e-05
     Pox_A14   6 llknyystvliaGiiLLilacifafvdfskststtdkawralsivsFilgivillglllfsmygr 70 
                  l +yys  +++G+++L +  ++  + +     ++      l  + F+lgi i++g+l +    +
  EFC38768.1 113 KLDKYYSVGVVVGVVILCVISLCLVIPLIVDMDNS--LVYFLIAIPFVLGIGIVVGVLFYFLRRK 175
                 6789************************9998855..67788999***********999865544 PP

>> PITH  PITH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   1.0   1.6e-05     0.026      15      69 ..      30      84 ..      25     110 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.6e-05
        PITH 15 eseegsvkkvlkksweerldekkyleSdaDeqLlihipFtqsvklksllikstkk 69
                +s+e++++ +++k++ e++dek+  e + D  L+ +i++ ++ kl sl+i+ +++
  EFC38768.1 30 SSDEHTTSIIVEKPKMEKQDEKPTFEQEHDVKLVATIQLDSHTKLLSLKINEKEE 84
                455788999999***99*99999***************************76543 PP

>> POC3_POC4  20S proteasome chaperone assembly proteins 3 and 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.3   1.8e-05     0.029      10      72 ..      47     109 ..      38     126 .. 0.78
   2 ?   -1.9   0.0       1.9   3.1e+03      69      93 ..     194     218 ..     175     226 .. 0.65

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.8e-05
                 C----------EEEEEEEECCESSSSCEEEEEECCB--EEEEEEEE...EEEEEEEEES.HHHH CS
   POC3_POC4  10 lesesksltssedvevaihalhfsnkiplqiringemdstyevsskglllinyvyaidl.eees 72 
                 ++ e+ +++++ dv+++ +++ +s++ +l++ in++ +  ++++++ +l  n+vy  +    e+
  EFC38768.1  47 KQDEKPTFEQEHDVKLVATIQLDSHTKLLSLKINEKEENQLSSDQENYLIRNVVYPCNSlM-EK 109
                 4555666778**************************************9999999886642.32 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.9
                 HHHHHHHH---EEEEEEES-TTHCC CS
   POC3_POC4  69 eeesvsdklsdvevvvllgnssdmk 93 
                 eee ++++ +++e++ +  +  + k
  EFC38768.1 194 EEERIRESNAEYESFFKDSERVNVK 218
                 7777777777777766655555554 PP

>> NEMP  NEMP family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.6   3.1e-05      0.05      37      95 ..     117     179 ..     109     205 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 3.1e-05
        NEMP  37 YYssgmalGillsllivlfqlmkllpk..kslfylllygsw..gvslyllqqlsenlksilee 95 
                 YYs+g+++G+++  +i l ++  l+     sl+y+l++  +  g+++++  ++  + + i+++
  EFC38768.1 117 YYSVGVVVGVVILCVISLCLVIPLIVDmdNSLVYFLIAIPFvlGIGIVVGVLFYFLRRKIVNN 179
                 **********76666666666665555588888888776542344444333333333444444 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   2.5   4.2e-05     0.069     349     431 ..      92     173 ..      15     189 .. 0.51

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.2e-05
     DUF2207 349 kakkfkkalkkwksavkkkergyfdkkgkkklkklsalglgliilglilillallllvll......lvfllilllillliaiivlllfs 431
                 ++  +++ +   +s ++k         +k  ++++  + +g++il++i ++l++ l+v +      + ++  ++l++++++ +++++++
  EFC38768.1  92 ENYLIRNVVYPCNSLMEK-------HVSKLDKYYSVGVVVGVVILCVISLCLVIPLIVDMdnslvyFLIAIPFVLGIGIVVGVLFYFLR 173
                 333444444444444444.......1112223333334444444444444444444444466654444444444444444444444443 PP

>> CRPA  Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.6   5.1e-05     0.084      64     115 ..     118     170 ..      84     203 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 5.1e-05
        CRPA  64 fkitlvvlGilLviaglallf..ilqaqlganafylliPaviGlvkllvtslsm 115
                 + +++vv  ++L +++l l+   i++   +   f+++iP v+G + ++v++l++
  EFC38768.1 118 YSVGVVVGVVILCVISLCLVIplIVDMDNSLVYFLIAIPFVLG-IGIVVGVLFY 170
                 55776666678888888887611455555555555699*****.5788888875 PP

>> Vpu  Vpu protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   0.00011      0.18       1      63 [.     144     207 ..     144     212 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00011
         Vpu   1 MlsleliglialivaliiaivvWtivyreykkikkqkei.erlikrireraedSgnESdGeeee 63 
                 M +  ++ lia+ ++l i ivv  + y   +ki +++ i e  i+r+  ++e+   ES+ e e 
  EFC38768.1 144 MDNSLVYFLIAIPFVLGIGIVVGVLFYFLRRKIVNNHSIcEAEIERVLRVEEERIRESNAEYES 207
                 667778899999999999******************88845679***************99885 PP

>> Pro_sub2  Prodomain subtilisin 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.2      0.18   2.9e+02       2      31 ..      57      86 ..      56     107 .. 0.76
   2 ?   10.1   0.6   0.00044      0.72      21      68 ..      97     146 ..      88     155 .. 0.77
   3 ?   -2.6   0.0         4   6.5e+03      24      38 ..     198     212 ..     195     223 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.18
    Pro_sub2  2 kqelilvlkGdldlhskemktvikeadekf 31
                ++++ lv   +ld h+k +   i+e +e+ 
  EFC38768.1 57 EHDVKLVATIQLDSHTKLLSLKINEKEENQ 86
                57778889999*********9999988764 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00044
    Pro_sub2  21 ktvikeadekfekyikr..hfkevdkirydisspinflcffiptifdmnn 68 
                 ++v+  +++ +ek++ +  ++ +v  ++  +   +  lc+ ip+i+dm+n
  EFC38768.1  97 RNVVYPCNSLMEKHVSKldKYYSVGVVVGVVILCVISLCLVIPLIVDMDN 146
                 6677777888888887533566777777777788889***********99 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 4
    Pro_sub2  24 ikeadekfekyikrh 38 
                 i+e+++++e ++k  
  EFC38768.1 198 IRESNAEYESFFKDS 212
                 789999999998865 PP

>> DUF2721  Protein of unknown function (DUF2721)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   1.9   0.00073       1.2      70     118 ..     122     173 ..     105     182 .. 0.77
   2 ?   -1.7   0.1       1.5   2.5e+03      27      55 ..     196     223 ..     188     239 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00073
     DUF2721  70 lvlsallvvlvvlllflsallsldls...llaailfvlalllllvslllflr 118
                 +v++++++++++l+l++  ++++d s   +l+ai fvl++ ++++ l++flr
  EFC38768.1 122 VVVGVVILCVISLCLVIPLIVDMDNSlvyFLIAIPFVLGIGIVVGVLFYFLR 173
                 46667777777777777666666655111679999***************98 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.5
     DUF2721  27 drirqLedeleelaeeeeedeelakeikn 55 
                 +rir+ ++e+e+  +++e+  +++ +++ 
  EFC38768.1 196 ERIRESNAEYESFFKDSER-VNVKLQLDY 223
                 5899999999988777666.666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1459  (0.0813765); expected 358.6 (0.02)
Passed bias filter:                      755  (0.0421105); expected 358.6 (0.02)
Passed Vit filter:                        92  (0.00513135); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.67u 0.38s 00:00:01.05 Elapsed: 00:00:00.54
# Mc/sec: 1395.95
//
Query:       EFC38769.1  [L=307]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.7e-25   87.4   0.5    2.2e-24   85.9   0.0    1.9  2  Lipase_3  Lipase (class 3)
    5.8e-05   22.8   0.2    0.00014   21.5   0.2    1.6  1  DUF2974   Protein of unknown function (DUF2974)
  ------ inclusion threshold ------
      0.018   14.6   0.0      0.027   14.0   0.0    1.2  1  PE-PPE    PE-PPE domain


Domain annotation for each model (and alignments):
>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.32   1.9e+03      48      68 ..      36      56 ..      14      56 .. 0.75
   2 !   85.9   0.0   3.7e-28   2.2e-24       1     128 [.     125     250 ..     125     271 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.32
                HHHHHHHHHHHHHHTT-EEEE CS
    Lipase_3 48 reqvlkelkrllekypeysiv 68
                 ++v k++k+l+++ +e++iv
  EFC38769.1 36 IKNVAKTVKSLVNSDKEMEIV 56
                457788899999988888876 PP

  == domain 2  score: 85.9 bits;  conditional E-value: 3.7e-28
                 EEEE----..------------EEE-HHHH-GTT-EEEHHHHHHHHS-HHHHHHHHHHHHHHHTT-.EEEEEEEETHHHHHHHHHHHHHHHTT-SS..- CS
    Lipase_3   1 vvafRGte..sakdwltdldfslteakellekeggkvhsgfleayeeslreqvlkelkrllekype.ysivvtGHSLGgalAlLaaldlvengene..k 94 
                 v++fRG e  + k+w+  ++f+lt+++      +gkvh+gfl+ y+ +l+e++ + lk+++++ ++  ++++tGHS G+a+ ++aald+v+ +  +  +
  EFC38769.1 125 VISFRGVEpkNVKNWADSFNFKLTDFNG-----NGKVHRGFLQHYK-KLKETLVAALKKVFSSENQvDTVMFTGHSKGAAVTSIAALDFVSSKYVDykN 217
                 79*****999*****************9.....6************.************888887637899**********************999999 PP

                 --EEEEEES----B-HHHHHHHHT-TTEEEEEEE CS
    Lipase_3  95 kkvtvvtfGqPrvgnkefaklvdsqlnkkvlrvv 128
                  k++++tfGqPr+g+ +f +++++ +++ + rvv
  EFC38769.1 218 AKIKLITFGQPRTGDAKFVSTINAAIPE-FARVV 250
                 9**********************99999.88887 PP

>> DUF2974  Protein of unknown function (DUF2974)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.2   2.4e-08   0.00014      24     104 ..     110     206 ..      95     226 .. 0.78

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 2.4e-08
     DUF2974  24 qkqfaaatfrleedtlvvaFRGTd.dtlvgWkedfnmafrsevpaqesAlkYlnkileeseg................kiylgGhSkGGnlAvyaamn 104
                 q+ f+ + ++   +t v++FRG + +++  W + fn++ ++   + +    +l++  +  e                 +++ +GhSkG+ +   aa++
  EFC38769.1 110 QTSFK-IYYNALTRTVVISFRGVEpKNVKNWADSFNFKLTDFNGNGKVHRGFLQHYKKLKETlvaalkkvfssenqvdTVMFTGHSKGAAVTSIAALD 206
                 44444.4455568999******98467999******998888877777777777776666667789999*******988***********99999887 PP

>> PE-PPE  PE-PPE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   4.6e-06     0.027      35     135 ..     174     265 ..     157     275 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 4.6e-06
      PE-PPE  35 nLeaairaelaagekvvvfGySqgalvasnekarlaalsepaa..pdqlsfvlvgnpnrpnggllarfpggltipi..lgitftgatptdsqydTvdvv 129
                  L+++ ++e+   ++v+  G S+ga+v s +  +  + s++++    +++ +++g+p   +  ++++++    ip+    ++f  +++ + +y      
  EFC38769.1 174 ALKKVFSSEN-QVDTVMFTGHSKGAAVTSIAALDFVS-SKYVDykNAKIKLITFGQPRTGDAKFVSTINA--AIPEfaRVVDFYKSKKNKVRY------ 262
                 4555555544.67889***************999988.666666689***********999999999977..899833345555555554444...... PP

      PE-PPE 130 aqYDgv 135
                    D v
  EFC38769.1 263 ---DLV 265
                 ...444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1272  (0.0709465); expected 358.6 (0.02)
Passed bias filter:                      645  (0.0359752); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1879.60
//
Query:       EFC38770.1  [L=103]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       856  (0.0477439); expected 358.6 (0.02)
Passed bias filter:                      553  (0.0308439); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 666.27
//
Query:       EFC38771.1  [L=174]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00027   21.7   0.8        0.2   12.5   0.0    2.2  2  TraD_N         F sex factor protein N terminal
     0.0029   17.9   1.6     0.0041   17.4   1.6    1.2  1  DUF996         Protein of unknown function (DUF996)
      0.006   15.8   3.1     0.0095   15.1   3.1    1.4  1  DUF3413        Domain of unknown function (DUF3413)
  ------ inclusion threshold ------
      0.014   14.8   4.3      0.014   14.8   4.3    1.6  2  GpcrRhopsn4    Rhodopsin-like GPCR transmembrane domain
      0.021   15.2   0.0       0.52   10.7   0.0    2.2  2  DUF5383        Family of unknown function (DUF5383)
      0.044   14.1   0.5      0.065   13.5   0.5    1.4  1  DUF1772        Domain of unknown function (DUF1772)
       0.36   11.0   4.4       0.69   10.1   3.7    1.8  1  CD225          Interferon-induced transmembrane protein
        5.1    7.4   5.2        2.2    8.6   0.1    2.5  3  zf-LITAF-like  LITAF-like zinc ribbon domain


Domain annotation for each model (and alignments):
>> TraD_N  F sex factor protein N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.0   8.8e-05       0.2      28      94 .]      33     111 ..      29     111 .. 0.87
   2 !    7.8   0.1    0.0025       5.6      63      92 ..     136     165 ..     123     167 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8.8e-05
      TraD_N  28 lyY....waieeyvslknligsaafydi.ktikitlasllakkwihlaaeqll.......eklqlsalvagvialvifl 94 
                 ++Y    ++ ++ ++l +  +++ +y+   ++ +t+ + +++  +  a+++ +       +k+++++l+a vi++++f+
  EFC38771.1  33 IHYtshpFHENLKQNLIPPQQQQQVYTTtAETTSTPLVNRQEHPYTNAGTNNWfhekhqtDKAKNAFLIATVISFLVFF 111
                 66666667777778888888889****988899999999999999999**999***********************996 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0025
      TraD_N  63 akkwihlaaeqlleklqlsalvagvialvi 92 
                 a k+ +la+ ++++  +++++++ +i++++
  EFC38771.1 136 ARKYGQLAKSTFWSLVAFNVCLSILIVIIT 165
                 578999********************9987 PP

>> DUF996  Protein of unknown function (DUF996)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   1.6   1.9e-06    0.0041      18      89 ..      88     166 ..      84     172 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.9e-06
      DUF996  18 kavndekifsnaliafilsiialvvailalllvlgalatalelpgleeaas.......lilllllvliiayvlliisav 89 
                 ++ + +k ++ +lia+++s+  +++++  ++ + ++++ ++++ +++ a         ++  l+++ + + +l++i ++
  EFC38771.1  88 EKHQTDKAKNAFLIATVISFLVFFIFTPFFACIPYMFVFKYSSHEVRGARKygqlaksTFWSLVAFNVCLSILIVIITL 166
                 67788999******************99999988888888888888887778888886333333333555555555443 PP

>> DUF3413  Domain of unknown function (DUF3413)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   3.1   4.2e-06    0.0095       5      74 ..      94     165 ..      76     172 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 4.2e-06
     DUF3413   5 rekvsqlirwghwFalfnillalliglrYlfasdlPetl..lgllYlvvsllghfsflafliyllvlfpltf 74 
                 + k+  li  +  F +f i+  ++ ++ Y+f++++++++   ++ Y  +   ++ s++af ++l +l  ++ 
  EFC38771.1  94 KAKNAFLIATVISFLVFFIFTPFFACIPYMFVFKYSSHEvrGARKYGQLAKSTFWSLVAFNVCLSILIVIIT 165
                 4556668899999************************99778999******************999855444 PP

>> GpcrRhopsn4  Rhodopsin-like GPCR transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   4.3   6.4e-06     0.014     198     241 ..      89     133 ..      79     140 .. 0.84
   2 ?   -1.8   0.1      0.74   1.7e+03     141     155 ..     150     164 ..     138     170 .. 0.52

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 6.4e-06
  GpcrRhopsn4 198 kkekskkkkqFllkfgivgllwflsfPvlviiavf.vdpyvrekv 241
                  k +++k+k+ Fl+  +i++l++f+  P++++i ++ v +y  ++v
   EFC38771.1  89 KHQTDKAKNAFLIATVISFLVFFIFTPFFACIPYMfVFKYSSHEV 133
                  3456669**************************998888887776 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.74
  GpcrRhopsn4 141 livlivvlqvilvil 155
                  l+++ v+l +++vi+
   EFC38771.1 150 LVAFNVCLSILIVII 164
                  444444444444443 PP

>> DUF5383  Family of unknown function (DUF5383)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00023      0.52      48     122 ..      42     124 ..       2     125 .. 0.68
   2 ?    2.6   0.0     0.076   1.7e+02      97     120 ..     149     172 ..     129     174 .] 0.80

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00023
     DUF5383  48 eelkesLfassek.esntiaakakelgLfseekesvkqsate...qes....eeksnlLpillillivllivvllivliPkva 122
                 e+lk++L   +++ +  t++a+  +  L +++++ +++++t+   +e+    + k ++L    i+++v+ i++ ++  iP ++
  EFC38771.1  42 ENLKQNLIPPQQQqQVYTTTAETTSTPLVNRQEHPYTNAGTNnwfHEKhqtdKAKNAFLIATVISFLVFFIFTPFFACIPYMF 124
                 45666666655554777888888888888888888888777522212233447889999999999999999999999999875 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.076
     DUF5383  97 lLpillillivllivvllivliPk 120
                 +L  + ++l +l++++ l+v +Pk
  EFC38771.1 149 SLVAFNVCLSILIVIITLAVTLPK 172
                 577777888889999999999999 PP

>> DUF1772  Domain of unknown function (DUF1772)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.5   2.9e-05     0.065      36      89 ..      96     173 ..      57     174 .] 0.66

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.9e-05
     DUF1772  36 kavfpplallsalafayla.........................araasrgarllylaaaallllsivpyTllvmvPtN 89 
                 k +f  + ++s l+f+  +                           + ++++++ ++a  ++l++ iv++Tl+v  P N
  EFC38771.1  96 KNAFLIATVISFLVFFI-FtpffacipymfvfkysshevrgarkYGQLAKSTFWSLVAFNVCLSILIVIITLAVTLPKN 173
                 33333344444444443.147888888888999999******99666666666666699999************99977 PP

>> CD225  Interferon-induced transmembrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   3.7   0.00031      0.69       5      64 ..     107     168 ..     103     170 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00031
       CD225   5 ylvwsifntlfcclplGivAlvySvkvrdrkmvGdvegAqsasstA..kllniialvlgiil 64 
                 +lv+ if+ +f c+p  +v  + S++vr + + G+++++   s  A   +l+i+ +++++++
  EFC38771.1 107 FLVFFIFTPFFACIPYMFVFKYSSHEVRGARKYGQLAKSTFWSLVAfnVCLSILIVIITLAV 168
                 799999*********************************99999993335555555555555 PP

>> zf-LITAF-like  LITAF-like zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       1.6   3.5e+03      10      24 ..      52      66 ..      47      70 .. 0.73
   2 ?    8.6   0.1   0.00096       2.2      27      49 ..     103     124 ..      82     132 .. 0.62
   3 ?    0.3   0.1       0.4   8.9e+02      26      42 ..     147     161 ..     137     172 .. 0.50

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.6
  zf-LITAF-like 10 aCqqrvvTsveyksg 24
                   + qq+v T++ ++++
     EFC38771.1 52 QQQQQVYTTTAETTS 66
                   557888888776654 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00096
  zf-LITAF-like  27 twllalllclfgcllccliPfcv 49 
                    t + +l++++f+  ++ +iP+++
     EFC38771.1 103 TVISFLVFFIFT-PFFACIPYMF 124
                    333345566666.577779*987 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.4
  zf-LITAF-like  26 ltwllalllclfgcllc 42 
                    ++ l+a+ +cl ++  +
     EFC38771.1 147 FWSLVAFNVCLSIL--I 161
                    33333444444433..1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (174 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1072  (0.0597914); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.43u 0.25s 00:00:00.68 Elapsed: 00:00:00.42
# Mc/sec: 1251.78
//
Query:       EFC38772.1  [L=110]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00039   20.7   0.0     0.0011   19.3   0.0    1.6  2  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   5.9e-08    0.0011      60      98 ..       9      46 ..       2      51 .. 0.82
   2 ?   -0.0   0.0     0.059   1.1e+03      51      74 ..      45      68 ..      44      94 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 5.9e-08
                HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHHHH CS
          C2 60 leeakLeveVfdndrlskddfiGkveiplstllsgeeae 98
                +e +++ +eVfd+dr   +d+iGk++++l++l++g +++
  EFC38772.1  9 PEIETIYFEVFDYDR-LVNDVIGKASVSLDSLEKGIAQQ 46
                567899*********.88889**********88876655 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.059
                EEEEEEESCHTTSEEEEEEEEECS CS
          C2 51 ekftfevaeleeakLeveVfdndr 74
                +++t+++++ ++ +L++e++ +d 
  EFC38772.1 45 QQLTLNLHNAQKGTLTIELLAEDF 68
                677788888888888888877664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (110 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       337  (0.0187964); expected 358.6 (0.02)
Passed bias filter:                      307  (0.0171231); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.49
# Mc/sec: 678.93
//
Query:       EFC38773.1  [L=264]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-23   83.0   0.0    2.3e-23   82.5   0.0    1.3  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.5   0.0   1.3e-27   2.3e-23       2      98 ..       3     101 ..       2     118 .. 0.94

  Alignments for each domain:
  == domain 1  score: 82.5 bits;  conditional E-value: 1.3e-27
                 EEEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESC...HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHHH CS
          C2   2 klevtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvWnekftfevae...leeakLeveVfdndrlskddfiGkveiplstllsgeea 97 
                 kl++tvi+A++L +kd +g+sdp+vk+++ g+  +kT+++k+++nP Wn  f+++++    +e +++ + V+d+dr+s++d+iGk++ +l++l++g ++
  EFC38773.1   3 KLKLTVIHARDLDAKDMGGTSDPFVKIKI-GTLQVKTEIVKKNCNPDWNAVFNLDLPAkfdPEFESIYFDVYDYDRFSSNDLIGKTSARLDNLEKGIAQ 100
                 699**************************.********999999*************999********************************8777655 PP

                 H CS
          C2  98 e 98 
                 +
  EFC38773.1 101 Q 101
                 5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (264 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       647  (0.0360868); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.47
# Mc/sec: 1676.38
//
Query:       EFC38774.1  [L=265]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-25   88.3   0.0    4.6e-25   87.9   0.0    1.2  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.9   0.0   2.6e-29   4.6e-25       1      99 [.       2     102 ..       2     106 .. 0.95

  Alignments for each domain:
  == domain 1  score: 87.9 bits;  conditional E-value: 2.6e-29
                 TEEEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESC...HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHH CS
          C2   1 gklevtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvWnekftfevae...leeakLeveVfdndrlskddfiGkveiplstllsgee 96 
                 gkl++tvi+A+nL+ kd++g+sdpyv+v++ g++ +kT+ i++++nP+Wn ++ f++++   +++++  +eV+d+dr++++d+iGk+++ l tl +g++
  EFC38774.1   2 GKLKITVISARNLEGKDVGGTSDPYVRVTI-GSVQRKTDHISKNCNPTWNTTLFFDLPPsvnPASESAVFEVYDYDRFGGNDIIGKATVALGTLYKGQP 99 
                 68****************************.********999999************************************************999998 PP

                 HHE CS
          C2  97 aeg 99 
                 ++ 
  EFC38774.1 100 QRV 102
                 765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (265 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       433  (0.0241508); expected 358.6 (0.02)
Passed bias filter:                      256  (0.0142785); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 1675.25
//
Query:       EFC38775.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       510  (0.0284455); expected 358.6 (0.02)
Passed bias filter:                      331  (0.0184617); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.26s 00:00:00.70 Elapsed: 00:00:00.43
# Mc/sec: 865.96
//
Query:       EFC38776.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-23   83.4   0.0    1.7e-23   82.8   0.0    1.3  1  C2        C2 domain
     0.0019   18.5  36.5     0.0024   18.2  36.5    1.2  1  Pro-rich  Proline-rich


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.8   0.0   1.9e-27   1.7e-23       1      97 [.       2     100 ..       2     106 .. 0.94

  Alignments for each domain:
  == domain 1  score: 82.8 bits;  conditional E-value: 1.9e-27
                 TEEEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEEEEEEEEEESC...HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHH CS
          C2   1 gklevtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvWnekftfevae...leeakLeveVfdndrlskddfiGkveiplstllsgee 96 
                 gkl+vt+i+A++L+ kd++g+sdp+v+vs+ g+ k+kT+   +++nP+Wn ++ f++++   +++++  +eVfd+drl+++d+iG+++i l tl +g++
  EFC38776.1   2 GKLKVTIISARDLEGKDIGGTSDPFVVVSV-GTIKHKTDHLTKTTNPTWNTSLFFDLPPsvnPATESASFEVFDYDRLGSSDLIGRATIALGTLYKGHA 99 
                 68****************************.********889999************************************************888876 PP

                 H CS
          C2  97 a 97 
                 +
  EFC38776.1 100 Q 100
                 5 PP

>> Pro-rich  Proline-rich
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2  36.5   2.7e-07    0.0024      36     143 ..     123     222 ..      89     224 .] 0.49

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 2.7e-07
    Pro-rich  36 leeqsqqggekpqkpppgglqprppasdenkpeqgpppqggpqq..rPpqggkkkpqgPPpqggpqrppPGkp..qg...PPpqggnqqr.rppqPggk 126
                  ++  +++ +++ +p++gg++p++     + p+qg p+qg pqq              PP+qg pq+p  G+p  qg   PP qg +qq   ppq g  
  EFC38776.1 123 FGQAIPTTTQTTTNPQQGGFPPQQQ----GYPQQGYPQQGYPQQqmY-----------PPQQGYPQQPYYGQPpmQGygyPPEQGYPQQGgFPPQQG-Y 205
                 4444455555555555555555533....334444444444444332...........444444443322222111111244444444442233333.4 PP

    Pro-rich 127 pqgpppqgppkqggpkP 143
                 pq+ ppq+ p+q+g +P
  EFC38776.1 206 PQQYPPQQYPPQQGYPP 222
                 44444444555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       278  (0.0155056); expected 358.6 (0.02)
Passed bias filter:                      168  (0.00937029); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.28s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1512.20
//
Query:       EFC38777.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2953  (0.164705); expected 358.6 (0.02)
Passed bias filter:                      935  (0.0521501); expected 358.6 (0.02)
Passed Vit filter:                       141  (0.00786435); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.46
# Mc/sec: 2070.39
//
Query:       EFC38778.1  [L=1033]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.6e-21   75.1   0.7    2.5e-20   73.0   0.7    2.2  1  HATPase_c     Histidine kinase-, DNA gyrase B-, and HSP90-lik
    2.6e-20   72.6   1.8    6.3e-18   65.0   0.2    3.1  3  Response_reg  Response regulator receiver domain
    5.9e-12   45.4   0.2    1.7e-11   44.0   0.1    1.9  2  HisKA         His Kinase A (phospho-acceptor) domain


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.0   0.7   4.2e-24   2.5e-20       1     111 [.     552     702 ..     552     703 .. 0.85

  Alignments for each domain:
  == domain 1  score: 73.0 bits;  conditional E-value: 4.2e-24
                 EHHHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE..........EE.......TEEEEEEEESSSSSTTHHHT...................GTCS..TT CS
   HATPase_c   1 gdekrLrqiisnlvdNavkfatkageieveika..........se.......ddlvisveDnGiGipkedlk...................klfe..kf 61 
                 gd+ r+ qi+ nlv+N++k+ tk+g++ +++k+          +e        +l+i+ +DnG+Gi+++++                    + f+   f
  EFC38778.1 552 GDSVRISQIVMNLVSNSIKY-TKGGQVLLKCKKakdeelklhfQEeeikkncFYLKIECQDNGCGISESQIGslfkpfhiiekqektqgfeHYFKqsEF 649
                 799*****************.9999998888876654444444115667789********************999999999999999666644444444 PP

                 CH...HCSTCHTSTSSSHHHHHHHHHHHHTTTEEEEEEETTTEEEEEEEEESS CS
   HATPase_c  62 sq...ddstkrggggtGlGlsivkklvelmgGeiwvesepgrGttftftlple 111
                 ++    +s+ +++ ++GlGl i k+++e+m+G+i v+s+ g+Gtt+ +++ple
  EFC38778.1 650 TKlnnGGSSLINTNRNGLGLNITKQIIEKMEGKIIVNSRVGEGTTMNVYIPLE 702
                 4488899*******************************************997 PP

>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.1    0.0027        16       1      39 [.     743     779 ..     743     793 .. 0.72
   2 ?   -2.8   0.0       1.2   6.9e+03      94     109 ..     834     849 ..     826     851 .. 0.79
   3 !   65.0   0.2   1.1e-21   6.3e-18       1     111 [.     912    1027 ..     912    1028 .. 0.94

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0027
                   EEEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHH CS
  Response_reg   1 vlivdDdplvrellrqlleeegyeevaeaedgkealell 39 
                   ++i+d+dp++r++l+++l+   +++v   +d +   + +
    EFC38778.1 743 IIIIDEDPVFRQVLSSYLNL--FKRVVLIQDFETHADFV 779
                   89****************93..33355555555444444 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.2
                   ESEEEESSG-HHHHHH CS
  Response_reg  94 addflsKpfdpeeLlk 109
                    + +l+Kp++  +L +
    EFC38778.1 834 TFSYLTKPIKFVDLAD 849
                   5789*****9988865 PP

  == domain 3  score: 65.0 bits;  conditional E-value: 1.1e-21
                    EEEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHHHHHHESEEEEESSCSSSEHHHHHHHHHHCT......TTSEEEEEESSTSHHHHHHH CS
  Response_reg    1 vlivdDdplvrellrqlleeegyeevaeaedgkealellkeekvdlillDinmpgmdGlellkeireed......pelpviiltahseeedavea 89  
                    +++vdD+ ++r++l+++l+  g++++++a dg e+++++k++k+d+illD+ mp ++G e++++ir+ +      +++p++++ta++  e +   
    EFC38778.1  912 IFVVDDNAVNRKILTKMLRVIGFKDIDVACDGMECFNMYKRKKYDIILLDCFMPILSGKEACEMIRKAEkqneteKQTPILAITANTW-ESVDTL 1005
                    89***************************************************************988867777777*******8885.89999* PP

                    HHCTESEEEESSG-HHHHHHHH CS
  Response_reg   90 lkagaddflsKpfdpeeLlkal 111 
                    +  g d ++ Kp+  + L+k +
    EFC38778.1 1006 VGHGFDSVIYKPILLDSLKKEV 1027
                    *************999999875 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.1   2.8e-15   1.7e-11       2      65 ..     426     502 ..     425     504 .. 0.92
   2 ?   -4.2   0.0         3   1.8e+04      28      45 ..     730     745 ..     724     755 .. 0.74

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 2.8e-15
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHC...............T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHH CS
       HisKA   2 lgrflagvaHELrtPLsailgnaeaLkre.............gklteelkeyletiesearrldhlvedlLdlsrie 65 
                 ++rf+a+++HELr+PL+ai+g +e++k+                 + +  e++++++++a  l+h+++  L++s++e
  EFC38778.1 426 KTRFIASLSHELRNPLHAIIGSVELIKNIyksedcsesckhcMVSNASFSEMINDVHENAALLLHILSSSLQMSSME 502
                 89************************9888888999999999555789999************************98 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 3
                 HC..T-HSSCHHHHHHHH CS
       HisKA  28 kregklteelkeyletie 45 
                  +   l+e++ + l +i+
  EFC38778.1 730 LD--VLSEDQSQDLSIII 745
                 45..57889999888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1033 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1347  (0.0751297); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.83u 0.31s 00:00:01.13 Elapsed: 00:00:00.51
# Mc/sec: 6091.98
//
Query:       EFC38779.1  [L=381]
Description: Hypothetical protein NAEGRDRAFT_73563 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-07   30.0   0.2    1.1e-06   28.9   0.2    1.6  1  Laminin_G_3  Concanavalin A-like lectin/glucanases superfamil


Domain annotation for each model (and alignments):
>> Laminin_G_3  Concanavalin A-like lectin/glucanases superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.9   0.2     6e-11   1.1e-06      16     152 .]     180     305 ..     169     305 .. 0.78

  Alignments for each domain:
  == domain 1  score: 28.9 bits;  conditional E-value: 6e-11
  Laminin_G_3  16 tssfTvsaWvkpdslpsaaqiiissssdgrgfelgld.gsgrlrfsvnagngaeesvtsgasvpageWtHvavtydggtlrlYvNGvevgsatltggl 112
                   s+fT+++W +++++ s + ++i  + +  +++++l+ + g l++++n+++  ++ +   + +++++W+H + +++ +++++ vN     + +  +++
   EFC38779.1 180 MSNFTIEFWARFKQNVSGDLLTI--TCSA-SRSIKLSlSIGALYINFNTTD--MRFI---NYIAPDQWQHFVLVFEQDNIKVRVNQDYFLEYP--THS 267
                  589**************999999..7777.666666425578999999885..5555...6899********************987777764..443 PP

  Laminin_G_3 113 lsatsgplviGrdpggddpfdGlidevriynralsaaeIa 152
                     ++++l+     + + +  ++  e+r++n+a++ +eI+
   EFC38779.1 268 F--DKDSLISKIVLWEGVNMCADFTELRVWNYARTLEEIK 305
                  3..233444444448889999*****************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       548  (0.030565); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.26s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2384.13
//
Query:       EFC38780.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.1e-78  262.5   0.0      7e-78  262.3   0.0    1.0  1  Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase famil
     0.0025   17.0   0.1       0.38    9.8   0.0    2.9  2  Dus           Dihydrouridine synthase (Dus)


Domain annotation for each model (and alignments):
>> Oxidored_FMN  NADH:flavin oxidoreductase / NADH oxidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  262.3   0.0   7.8e-82     7e-78       2     340 ..      13     357 ..      12     359 .. 0.90

  Alignments for each domain:
  == domain 1  score: 262.3 bits;  conditional E-value: 7.8e-82
                   CCS-EEETTEEESSSEEE----S-TTTTTCS.HHHHHHHHHHHHHHTT-SEEEEEEEESSCCC-SCTTSEE-SSGGGHHHHHHHHHHHHHTT-EEEE CS
  Oxidored_FMN   2 LFkPikignmtLknRivmapmtrlraldkgnvledlaaeyysqraeipvtliiteaafvnpksggfdnapgiwdeeqieewrklteavhengskvvv 98 
                   LF+P+++   tLknRiv++pm++++a+d    ++++ ++++  r  ++ +l i+ea+ v+  +++ ++  gi+++e++  + k+++  he+g+ +++
    EFC38780.1  13 LFQPFTVRGLTLKNRIVVSPMCQYSATDGF--ANFWHVQHIGSRIVGGAGLFIVEATGVSDVGRISPGCLGIYKDEHVDMLSKIVQFAHEQGGHIGL 107
                   9************************99865..99*************************************************************** PP

                   EEE--GGGS..SCSTCEC...............SS.ESSSSSTTT-.S...CS-EE--HHHHHHHHHHHHHHHHHHHHTT-SEEEEEE-CTSHHHHH CS
  Oxidored_FMN  99 qlwhlGreakseyladqe.............vdspsdpvaldaqeeesaeevykkeltkeeikqliqefveAAkraieAgfDgVeihganGYLlnqF 182
                   ql h+Gr+a +  l +++             v++ps p+a+d++      ++++ elt  ei+++iq+fv+AAkrai+AgfD +eihga+GYL+  F
    EFC38780.1 108 QLNHAGRKASTGRLWEANsrkaltneqggwdVVGPS-PIAFDEH------HRIPAELTIVEIQEVIQQFVDAAKRAIKAGFDLIEIHGAHGYLISSF 197
                   *********987776666667799988888888888.8888888......45688****************************************** PP

                   H-TTT----STTSSSHHHHHHHHHHHHHHHHHHH-SSS.EEEEEECE--STT.S--HHHHHHHHHHHCHCCEEEEEEETT-SSSSSTTS-TTTTHHH CS
  Oxidored_FMN 183 lspksnkrtDeygGslenRarFllevvdaVkeavgeer.vgyRlSpedvvek.gldfaetaqkivllkelekrlkdgkklalvhaaeprkrgagsvr 277
                   ls+ snkr+DeygG  enR+rFl+e+v+ ++  + +e+ +++R+S++++v++ g ++ +t++ +++l++ +++l+d++++     a+    ++ s +
    EFC38780.1 198 LSQTSNKRSDEYGGCFENRIRFLVELVERIRANIPSEMpLFVRISADEYVGDeGWTMKDTTELAKILQKCGVDLLDCSSGGNNANAK--LLSPTSIV 292
                   ************************************************99762568889999***************9876532222..45666666 PP

                   CCTT.HHHHHHCCCH.SSEEEE-SS--SHHHHHHHHHTTS-SEEEESTHHHH-TTHHHHHHCCTC CS
  Oxidored_FMN 278 teqe.kntefvkevw.kkplitvgriadeekaaeivaegeadLvamgRefladpdlveklkkglp 340
                     ++  + e vk+ +   ++ +vg+i+d++ a++  + ++adLv +gR+ l dp ++ +++++l+
    EFC38780.1 293 QGYQvPFSEGVKKSVdGLATGAVGKIKDAQFANDLIKDQKADLVLIGRQELNDPYWPIRAAHELE 357
                   6777677777766551679******************************************9987 PP

>> Dus  Dihydrouridine synthase (Dus)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.8   0.1    0.0056        50     132     159 ..     161     188 ..     152     206 .. 0.89
   2 !    9.8   0.0   4.3e-05      0.38     176     225 ..     301     351 ..     201     368 .. 0.62

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.0056
                 ESSTTTC.HHHHHHHHHHCT-SEEEEES CS
         Dus 132 giddeeenalelakiveaaGaqaltvHg 159
                  i++  ++ +++ak++ +aG + + +Hg
  EFC38780.1 161 EIQEVIQQFVDAAKRAIKAGFDLIEIHG 188
                 567778899******************9 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 4.3e-05
                 HHHHHH-S.S-EEEESS--SHHHHHHHHHHH--SEEEESCHHCCSTTHHHH CS
         Dus 176 kevkqavs.ipviaNGdIkdaedaqaileetGadgvmigrgalgnPwlfae 225
                 + vk++v  +   a G Ikda+ a++ ++   ad v+igr  l++P+   +
  EFC38780.1 301 EGVKKSVDgLATGAVGKIKDAQFANDLIKDQKADLVLIGRQELNDPYWPIR 351
                 357888888888899*******************************87654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       420  (0.0234257); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 2319.94
//
Query:       EFC38781.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.6e-05   22.9   0.0    4.4e-05   22.6   0.0    1.1  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
      7e-05   23.1   0.0    0.00011   22.4   0.0    1.4  1  TrkA_N           TrkA-N domain
     0.0019   17.7   0.0     0.0026   17.3   0.0    1.2  1  Epimerase        NAD dependent epimerase/dehydratase family
     0.0043   16.5   0.1      0.096   12.1   0.1    2.0  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
  ------ inclusion threshold ------
      0.091   13.0   0.0       0.15   12.4   0.0    1.4  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma


Domain annotation for each model (and alignments):
>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   1.2e-08   4.4e-05       5     122 ..      59     176 ..      55     193 .. 0.78

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 1.2e-08
   3Beta_HSD   5 gaGFlGralvkeLvrlee....lkevrvlD....lrespelleelskvnvkkviegDvtdkdkleealegvdvvihlaslvdvagkltedeimkvnvkG 95 
                 gaG +G  l ++L++++       ++ vlD    ++e+++     ++vn +++i+gD++d+  l+e  ++++v     +++ +  +l++d+++++n + 
  EFC38781.1  59 GAGNVGYPLLHALISEKTsqpfFSKIIVLDahpiVQEETQF--AKEHVNQIEYIQGDMRDELILREIFNNSNVR----GVIVMWCELEKDTCQDINTQV 151
                 7899**********999733344589999965543444444..666778888*******************985....55566778999*******887 PP

   3Beta_HSD  96 TrnvleacvkagvrvlvYtSsaevvgp 122
                   + + + +++  + l++ Ss ev g 
  EFC38781.1 152 LMKQITMSRNN--PWLIFASSREVYGV 176
                 77777776665..89*******99886 PP

>> TrkA_N  TrkA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.0   3.2e-08   0.00011       3      69 ..      57     135 ..      55     163 .. 0.83

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 3.2e-08
                 EES-SHHHHHHHHHHHHTT......EEEEEEESSH...HHHHHHHHTT..SEEEES-TTSHHHHHHT.TGGGESEEEE- CS
      TrkA_N   3 iiGlGrvGrslaeeLsegg......kdvvvidkde...erveelreeg..levvvgdatdeevLeea.giekadaviaa 69 
                  iG+G+vG+ l++ L +++      ++++v d  +   e  + ++e+   +e+++gd  de +L+e+ + +++++vi++
  EFC38781.1  57 MIGAGNVGYPLLHALISEKtsqpffSKIIVLDAHPivqEETQFAKEHVnqIEYIQGDMRDELILREIfNNSNVRGVIVM 135
                 69***************6669****77******9966333444444446677**************9999999999997 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   7.1e-07    0.0026       5     125 ..      59     181 ..      55     198 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 7.1e-07
                 TTTSHHHHHHHHHHHHCT......SEEEEEES-STTTTCHHCHHC.....EEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHHHSHHHHHHHHT CS
   Epimerase   5 GatGfiGsalvkallekg......yevigldrlssasntarledl.....elveldltdrsalerlfkeeqpdavihlAavggvaassedpadfieknl 92 
                 Ga G +G  l++al +++       ++i+ld  +  +++ + ++      e +++d++d+  l+++f++ ++  vi +       +   ++  + ++n+
  EFC38781.1  59 GA-GNVGYPLLHALISEKtsqpffSKIIVLDAHPIVQEETQFAKEhvnqiEYIQGDMRDELILREIFNNSNVRGVIVM-------WCELEKDTCQDINT 149
                 44.77788888888777777777656777776644333333222244677*******************9*****998.......88888888889999 PP

                 HHHHHHHHHHHHHTCTEEEEEEEGGGGTSCSS.S CS
   Epimerase  93 qgtlnlleaarkagvkrllflsSsevYGkdae.q 125
                 q+ ++ + ++r +    l+f+sS evYG ++e q
  EFC38781.1 150 QVLMKQITMSRNNPW--LIFASSREVYGVVKEfQ 181
                 999999999987766..***********999842 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.1   2.7e-05     0.096       6     138 ..      60     179 ..      57     192 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 2.7e-05
                    TSHHHHHHHHHHHHCT-C...CEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHTTSHHHH CS
  GDP_Man_Dehyd   6 aGfiGsylaelLlekgye...vhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevqpdevynLAAqshVdvsfekPeyt 98 
                    aG +G  l++ L++++     +  i+ ++++  +++  + a   ke++ ++++ ++gD++D+  l++++++ +++ v+ + ++   d+        
     EFC38781.1  60 AGNVGYPLLHALISEKTSqpfFSKIIVLDAHPIVQEETQFA---KEHV-NQIEYIQGDMRDELILREIFNNSNVRGVIVMWCELEKDTCQ------ 145
                    67777777777777654411134455555555555544444...3443.699**********************9999877765433322...... PP

                    HHHHTHHHHHHHHHHHHCT..TTSEEEEEEEGGGG-S-SS CS
  GDP_Man_Dehyd  99 aevnvlGtlrLLeairalglekkvrfyqaStsEvYGkvqe 138
                         + t+ L++ i     +++  +++aS+ EvYG v+e
     EFC38781.1 146 ----DINTQVLMKQITMS--RNNPWLIFASSREVYGVVKE 179
                    ....25566777777554..35667778888888887776 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   4.1e-05      0.15       2      53 ..      56     108 ..      55     138 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 4.1e-05
                      EEE--SHHHHHHHHHHHCTCCT-G...EEEEEESSHHHHHHHHCHHTTTCEEEEE CS
  Sacchrp_dh_NADP   2 liiGaGsvGqavaellarhfdvda...eitvadrskeklealaakalgvrfeaia 53 
                      l+iGaG+vG ++++ l  ++  ++   +i+v d +    e++  + +++ +++i+
       EFC38781.1  56 LMIGAGNVGYPLLHALISEKTSQPffsKIIVLDAHPIVQEET--QFAKEHVNQIE 108
                      8***************99998887888******998874444..33445455444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1188.68
//
Query:       EFC38782.1  [L=597]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.1e-40  135.9  57.8      2e-09   36.9   4.0    7.1  9  Pentapeptide    Pentapeptide repeats (8 copies)
    3.8e-31  107.1  44.1    2.1e-12   47.1   5.5    4.9  5  Pentapeptide_4  Pentapeptide repeats (9 copies)
    4.6e-18   65.8   0.6    4.6e-18   65.8   0.6    2.5  2  TLD             TLD
    4.6e-14   52.3  28.3      4e-05   23.7   2.1    5.9  5  Pentapeptide_3  Pentapeptide repeats (9 copies)
    0.00073   19.8   0.1     0.0021   18.3   0.1    1.9  1  BTB_2           BTB/POZ domain
  ------ inclusion threshold ------
       0.61   10.1   9.1        1.9    8.5   2.9    2.7  2  CfAFP           Choristoneura fumiferana antifreeze protein (


Domain annotation for each model (and alignments):
>> Pentapeptide  Pentapeptide repeats (8 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   1.0     1e-08     3e-05      12      38 ..     167     193 ..     162     195 .. 0.82
   2 !   36.9   4.0   6.5e-13     2e-09       1      40 []     171     210 ..     171     210 .. 0.98
   3 !   34.2   1.3   4.7e-12   1.4e-08       2      40 .]     187     225 ..     187     225 .. 0.97
   4 !   32.7   2.5   1.4e-11   4.1e-08       1      39 [.     206     244 ..     206     245 .. 0.97
   5 !   27.7   0.4   5.1e-10   1.5e-06       1      39 [.     216     254 ..     216     254 .. 0.98
   6 !   27.6   3.0   5.3e-10   1.6e-06       1      40 []     226     265 ..     226     265 .. 0.98
   7 !   34.7   2.0   3.4e-12     1e-08       1      40 []     251     290 ..     251     290 .. 0.98
   8 !    5.8   0.2    0.0037        11      26      39 ..     327     340 ..     308     342 .. 0.41
   9 !    6.2   0.7    0.0027         8      13      37 ..     374     398 ..     372     402 .. 0.81

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 1e-08
                   CCEECCCESEEECT-B-TT-EECCEEE CS
  Pentapeptide  12 nLsganlsgAnLtgAnlsgAdLsganL 38 
                   +L +anl+++++t++n+sg dL+g  L
    EFC38782.1 167 KLAKANLTDCTFTNCNFSGMDLRGIVL 193
                   788999999999999999999998766 PP

  == domain 2  score: 36.9 bits;  conditional E-value: 6.5e-13
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   AnL+++ ++++n+sg +l+g +L+++nl g+ +sg+n+s+
    EFC38782.1 171 ANLTDCTFTNCNFSGMDLRGIVLDRSNLKGSVFSGCNMSN 210
                   9*************************************97 PP

  == domain 3  score: 34.2 bits;  conditional E-value: 4.7e-12
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   +L+g  L  +nL+g+ +sg+n+++A+l +++L ++n++g
    EFC38782.1 187 DLRGIVLDRSNLKGSVFSGCNMSNATLKNCCLVECNFEG 225
                   79999********************************98 PP

  == domain 4  score: 32.7 bits;  conditional E-value: 1.4e-11
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEEC CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLs 39 
                   +n+s+A L ++ L ++n++g++Lt+++l ++  +++ ++
    EFC38782.1 206 CNMSNATLKNCCLVECNFEGCDLTRTTLAHSSITRSSFK 244
                   9***********************************997 PP

  == domain 5  score: 27.7 bits;  conditional E-value: 5.1e-10
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEEC CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLs 39 
                   ++L ++n++g++L+++ l +++ t++++ +A L +++Ls
    EFC38782.1 216 CCLVECNFEGCDLTRTTLAHSSITRSSFKRAILPNSDLS 254
                   99***********************************97 PP

  == domain 6  score: 27.6 bits;  conditional E-value: 5.3e-10
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   ++L+++ L +++ +++++++A L +++ls+++Ls++nL++
    EFC38782.1 226 CDLTRTTLAHSSITRSSFKRAILPNSDLSCCNLSNSNLEN 265
                   9*************************************97 PP

  == domain 7  score: 34.7 bits;  conditional E-value: 3.4e-12
                   -B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   ++Ls +nLs++nL++ ++   +Lt+A +  ++L++++Ls+
    EFC38782.1 251 SDLSCCNLSNSNLENIDFDSVDLTKAIIWESNLTNSKLSN 290
                   69************************************97 PP

  == domain 8  score: 5.8 bits;  conditional E-value: 0.0037
                   -B-TT-EECCEEEC CS
  Pentapeptide  26 AnlsgAdLsganLs 39 
                   A ++++ +++ +++
    EFC38782.1 327 AKFQQCTFKRIDFR 340
                   33333333333333 PP

  == domain 9  score: 6.2 bits;  conditional E-value: 0.0027
                   CEECCCESEEECT-B-TT-EECCEE CS
  Pentapeptide  13 LsganlsgAnLtgAnlsgAdLsgan 37 
                   +++ +ls+ nL++ +++++ + ++n
    EFC38782.1 374 FQNIDLSNQNLIRFSFINTFFDQCN 398
                   6788888888888888888888887 PP

>> Pentapeptide_4  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   5.1     6e-13   1.8e-09      16      74 ..     171     230 ..     148     233 .. 0.61
   2 !   47.1   5.5   6.9e-16   2.1e-12       2      73 ..     172     249 ..     171     253 .. 0.90
   3 !   37.3   3.7   7.7e-13   2.3e-09       5      72 ..     220     293 ..     218     303 .. 0.72
   4 !   28.0   6.0   6.3e-10   1.9e-06       5      68 ..     310     384 ..     307     389 .. 0.87
   5 !    8.9   1.8   0.00055       1.6      13      52 ..     374     413 ..     374     418 .. 0.77

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 6e-13
  Pentapeptide_4  16 vnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsd.klkd 74 
                     +n++ +++ +cnF++ +l   ++d++nl+ + f+++++ +a++++c l ++nf++  l++
      EFC38782.1 171 ANLTDCTFTNCNFSGMDLRGIVLDRSNLKGSVFSGCNMSNATLKNCCLVECNFEGcDLTR 230
                     444444444444444444555566666666666666666666666666666666655554 PP

  == domain 2  score: 47.1 bits;  conditional E-value: 6.9e-16
  Pentapeptide_4   2 eftrcsfnncklsnvnFsea.....rlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsd.klk 73 
                      +t+c+f nc++s+++++ +     +l+++ F++c++sn+++++c l +++f+++dl+r+++ ++ ++ + f++  l 
      EFC38782.1 172 NLTDCTFTNCNFSGMDLRGIvldrsNLKGSVFSGCNMSNATLKNCCLVECNFEGCDLTRTTLAHSSITRSSFKRaILP 249
                     6789999999999999999888888***********************************************864665 PP

  == domain 3  score: 37.3 bits;  conditional E-value: 7.7e-13
  Pentapeptide_4   5 rcsfnncklsnvnFsearlrdcnFtecrl.....snvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsd.kl 72 
                      c f++c+l++++++++ + +++F+ + l     s +n++++nl+++df  vdl++a + ++nl+n+++s+  +
      EFC38782.1 220 ECNFEGCDLTRTTLAHSSITRSSFKRAILpnsdlSCCNLSNSNLENIDFDSVDLTKAIIWESNLTNSKLSNcII 293
                     6****************************666666666666666666666666666655555555555554344 PP

  == domain 4  score: 28.0 bits;  conditional E-value: 6.3e-10
  Pentapeptide_4   5 rcsfnncklsnvnFs.earlrdcnFtecrl..........snvnFdecnlsdvdfaevdlkrasFsgcnlknvnf 68 
                     +c+fn++ +++++F+ +a+++ c+F+ +++              Fd+c+++ + f+  ++k+++F++ +l+n n+
      EFC38782.1 310 NCQFNQSVFEEMDFNlKAKFQQCTFKRIDFrnslrdlspyEGNIFDSCLIDFSLFETREIKDIRFQNIDLSNQNL 384
                     8*************9889************75555554444444***************************9887 PP

  == domain 5  score: 8.9 bits;  conditional E-value: 0.00055
  Pentapeptide_4  13 lsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevd 52 
                     + n+++s+ +l++ +F +++++++n++ c  ++++f++++
      EFC38782.1 374 FQNIDLSNQNLIRFSFINTFFDQCNWNGCEYDSSSFEHIN 413
                     6677888888888888888888888888888888888776 PP

>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.45   1.4e+03      36      64 ..      69     100 ..      25     160 .. 0.75
   2 !   65.8   0.6   1.6e-21   4.6e-18       1     138 [.     438     595 ..     438     596 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.45
         TLD  36 ifGaflsqpwkssnkkfygdsesflfsl...s 64 
                  fG ++s +++++n++++ d +  +f+l    
  EFC38782.1  69 EFGKIISGQLSNANQPIFIDCDPKIFKLlynW 100
                 58888888888888888888888888885443 PP

  == domain 2  score: 65.8 bits;  conditional E-value: 1.6e-21
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpw.kssnkkfygdsesflfsl.....spkfkvyks..tgknkaylntssdglgfGg 91 
                 lly++++dg+s+++++ek++nkgptl lik+e+++ifG+++s +w + +n  ++ d++ flf++     + ++kv+k    ++++ +l+ + ++ + G 
  EFC38782.1 438 LLYRATRDGFSAKNFHEKCDNKGPTLSLIKSEHGNIFGGYTSVSWqSPENATYFPDESVFLFKVidvngQLELKVLKLqnGKQSNSVLMRDIYSVSYGF 536
                 79*******************************************5455569*****************6666666654244445555555568****9 PP

         TLD  92 gqpkfsLwidsslekgtsrhs...etfe.ngllsg...........aseerfkikdiEVWgl 138
                 +    +L+i ++  +g  + s   ++fe ++ + +            + ++fk+k+iEV+++
  EFC38782.1 537 P---CDLYICNESATGDYSYSnlgGSFElPEGIVEgsqqagnylhgGTRNNFKVKEIEVFKI 595
                 5...89999887777655544466999964455557888999999999************87 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   7.6   1.6e-07   0.00049       4      47 ..     176     226 ..     168     232 .. 0.49
   2 !   23.7   2.1   1.3e-08     4e-05       2      47 ..     199     246 ..     198     257 .. 0.88
   3 !   10.2   0.0   0.00022      0.66       1      47 [.     258     291 ..     243     302 .. 0.47
   4 !   16.0   1.3   3.4e-06      0.01       2      36 ..     309     342 ..     308     343 .. 0.91
   5 !    5.5   2.0    0.0066        20       3      39 ..     376     410 ..     370     413 .. 0.59

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.6e-07
  Pentapeptide_3   4 anFsgaadFr...............gatFsgaasFsnadFgsadFsgarFtgdvdFsga 47 
                     ++F+++ +F+               g++      Fs++++++a++ ++    +++F+g+
      EFC38782.1 176 CTFTNC-NFSgmdlrgivldrsnlkGSV------FSGCNMSNATLKNCCLV-ECNFEGC 226
                     444444.444333335555533333333......66666666666666665.6666555 PP

  == domain 2  score: 23.7 bits;  conditional E-value: 1.3e-08
  Pentapeptide_3   2 sganFsgaadFrgatFsgaa....sFsnadFgsadFsgarFtgdvdFsga 47 
                     +g++Fsg+ ++++at +++     +F+++d+++ +++++ +t +++F++a
      EFC38782.1 199 KGSVFSGC-NMSNATLKNCClvecNFEGCDLTRTTLAHSSIT-RSSFKRA 246
                     799*****.**********98888888888888888888888.8888887 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00022
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsga 47 
                     +s++n+++  dF+ +  ++a              +++ t ++ +s++
      EFC38782.1 258 LSNSNLENI-DFDSVDLTKA-----------IIWESNLT-NSKLSNC 291
                     233444444.4444444444...........44444444.4444333 PP

  == domain 4  score: 16.0 bits;  conditional E-value: 3.4e-06
  Pentapeptide_3   2 sganFsgaadFrgatFsgaasFsnadFgsadFsga 36 
                     ++++F ++  F++  F+  a F++++F ++dF+++
      EFC38782.1 309 VNCQFNQS-VFEEMDFNLKAKFQQCTFKRIDFRNS 342
                     69999999.999999999999**********9997 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.0066
  Pentapeptide_3   3 ganFsgaadFrgatFsgaasFsnadFgsadFsgarFt 39 
                     +  +s+  ++ +  F+++ +F++++++++  + + F+
      EFC38782.1 376 NIDLSNQ-NLIRFSFINT-FFDQCNWNGCEYDSSSFE 410
                     4444455.5556667777.677777766665555554 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.1   7.2e-07    0.0021       1      63 [.      43     104 ..      43     153 .. 0.79

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 7.2e-07
                 EEEEETTEEEEEEHHHHHTS...TTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS. CS
       BTB_2   1 vklnVgGtrfetskstLsrk...pdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtg 63 
                 ++lnVgGt f +s +t  +    p   +gk+ +     + +++++ +f+D +pk+F+ + n+++ +
  EFC38782.1  43 ITLNVGGTLFTVSVTTFINNpiePANEFGKIIS----GQLSNANQPIFIDCDPKIFKLLYNWLKFK 104
                 79***************9873335556666666....557888889*************9999875 PP

>> CfAFP  Choristoneura fumiferana antifreeze protein (CfAFP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   2.9   0.00062       1.9      33     105 ..     167     239 ..     140     247 .. 0.73
   2 ?    4.1   0.4     0.014        41      36      82 ..     250     296 ..     242     312 .. 0.59

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00062
       CfAFP  33 kcvkstltncyidnselessictrsqysdayvkksvttdcnidksqlygttctgsrydGvyitsstttgtris 105
                 k  k+ lt c   n +           + +++k sv + cn++++ l      + +++G  +t +t + ++i+
  EFC38782.1 167 KLAKANLTDCTFTNCNFSGMDLRGIVLDRSNLKGSVFSGCNMSNATLKNCCLVECNFEGCDLTRTTLAHSSIT 239
                 5556666666666666633333334456678888999999999999999999999999999999998888876 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.014
       CfAFP  36 kstltncyidnselessictrsqysdayvkksvttdcnidksqlygt 82 
                 +s l+ c++ ns+le+      + ++a + +s  t+ +++++ + gt
  EFC38782.1 250 NSDLSCCNLSNSNLENIDFDSVDLTKAIIWESNLTNSKLSNCIIKGT 296
                 45566677777777555444444455544444444444444444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (597 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       615  (0.034302); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.30s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 3595.61
//
Query:       EFC38783.1  [L=252]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.6e-33  112.7   3.1    9.9e-24   83.5   0.4    2.1  2  DUF4476          Domain of unknown function (DUF4476)
  ------ inclusion threshold ------
       0.49    9.4   5.4        2.9    6.9   1.6    2.2  2  PHA_synth_III_E  Poly(R)-hydroxyalkanoic acid synthase subuni


Domain annotation for each model (and alignments):
>> DUF4476  Domain of unknown function (DUF4476)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.9   0.1   3.7e-13   3.4e-09       7      62 ..     128     185 ..     123     187 .. 0.89
   2 !   83.5   0.4   1.1e-27   9.9e-24       2      91 .]     156     249 ..     155     249 .. 0.94

  Alignments for each domain:
  == domain 1  score: 36.9 bits;  conditional E-value: 3.7e-13
     DUF4476   7 feqlveklkkasfdddklklleqalank..aftcsqvvqllklfsfdddrlkalklla 62 
                  +q+++  ++asfd+dk+k++++++ ++   ++ + +v++l+lf fd+d++kal  l+
  EFC38783.1 128 AQQIIAACRNASFDNDKVKAVQTYSSSQccPVSGADLVTILNLFGFDNDKVKALTQLK 185
                 6899*******************55555589**********************98775 PP

  == domain 2  score: 83.5 bits;  conditional E-value: 1.1e-27
     DUF4476   2 msdksfeqlveklkkasfdddklklleq.alank..aftcsqvvqllklfsfdddrlkalkllapnivDkqns.etiidsftfssdkkkareil 91 
                 +++ s  +lv++l+ + fd+dk+k+l+q +++n+  ++++ +++++l++f fd+d++kal+l++++i+D++++ et++++f fs+d++kar ++
  EFC38783.1 156 CCPVSGADLVTILNLFGFDNDKVKALTQlKQTNNigQMSSTEAASVLRVFGFDNDKMKALDLIVTCIYDRKQAaETVVSVFGFSNDQSKARTCM 249
                 899999*********************9555555************************************9999****************9876 PP

>> PHA_synth_III_E  Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.2     0.002        18     154     183 ..      18      47 ..       7      51 .. 0.80
   2 ?    6.9   1.6   0.00032       2.9     151     187 ..      53      89 ..      43     105 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.002
  PHA_synth_III_E 154 neleaeqdqlresldrvlsaPalGytREeq 183
                       +++ +q   + +++  +++P++G++ +  
       EFC38783.1  18 MNMQPNQPYGQPQVGVSMNMPGFGVNMNVP 47 
                      46778888899*************997765 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.00032
  PHA_synth_III_E 151 lelneleaeqdqlresldrvlsaPalGytREeqeqlq 187
                       ++++  ++q q + +++  +++P++G++ +   q+q
       EFC38783.1  53 GQPQSFGQPQYQQQPQMGVSMNMPGFGVNMNVPPQQQ 89 
                      5678888999999***************999876666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (252 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 1677.12
//
Query:       EFC38784.1  [L=502]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-05   23.5   2.7    0.00014   22.1   2.7    1.8  1  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.079   13.3   0.3       0.19   12.1   0.3    1.7  1  DUF1958   Domain of unknown function (DUF1958)
       0.29   11.6   2.7       0.31   11.5   0.2    2.4  3  Guanylin  Guanylin precursor


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   2.7   2.3e-08   0.00014       4      92 ..     316     460 ..     313     498 .. 0.87

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 2.3e-08
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..................................................SHHHHHHHHHHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkka..................................................keqeelkkkake 52 
                 + ++d+++ + F+eF++ e seen+ ++++++++kk                                                   + +++  + a+e
  EFC38784.1 316 DTINDPALSEKFKEFCKIERSEENFLLLEKISDYKKLcersfeiqvflydtdilsgsdqfsetttssnedaskkkkgkkgftekdlyDIEKKKFEIAFE 414
                 56899******************************************************************************9997777777888*** PP

                 HHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHH CS
         RGS  53 Iyneylapsspkelnidkklreelekrleke......qpsrklfee 92 
                 I   +l+   ++++n +k++ +++++ l         +  ++lfe 
  EFC38784.1 415 IHTDFLDVRGERSVNTSKQIADNVKQSLDYFakgeneSLPENLFEI 460
                 **********************999988654444444444455554 PP

>> DUF1958  Domain of unknown function (DUF1958)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.3   3.2e-05      0.19      13      61 ..     391     439 ..     387     441 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.2e-05
     DUF1958  13 dGkkvtlekDlYdvvkkgaeptlklkdGkvsvdyereflskeiqaptvk 61 
                  Gkk   ekDlYd+ kk +e ++++    + v  er +  ++  a++vk
  EFC38784.1 391 KGKKGFTEKDLYDIEKKKFEIAFEIHTDFLDVRGERSVNTSKQIADNVK 439
                 5999999*******************99999999887654444456665 PP

>> Guanylin  Guanylin precursor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       2.8   1.7e+04      14      50 ..      53      66 ..      42      76 .. 0.55
   2 ?   11.5   0.2   5.3e-05      0.31      27      76 ..     305     354 ..     293     358 .. 0.82
   3 ?   -2.2   0.1      0.97   5.8e+03      74      79 ..     462     467 ..     444     470 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.8
                HHHHTTTTXXSSXXXXXSSXXXXXSSXSSTTSXGGGH CS
    Guanylin 14 esvkkLkdleelqeprlqaqsavpsvCsepalPeelk 50
                +s++k                       +++lP++lk
  EFC38784.1 53 DSIHK-----------------------QKSLPSSLK 66
                34444.......................444454443 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 5.3e-05
                 XXXXSSXXXXXSSXSSTTSXGGGHHHHTSTTHHHHHHHHHHHHTXSTTTT CS
    Guanylin  27 eprlqaqsavpsvCsepalPeelkpvCkekeaaeilqrLeaiaedesvCE 76 
                 + r  ++ +++   ++pal e++k  Ck + ++e +  Le+i++ +++CE
  EFC38784.1 305 QLRQVKKYMLMDTINDPALSEKFKEFCKIERSEENFLLLEKISDYKKLCE 354
                 333344457888999**********************************9 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.97
                 TTTTTS CS
    Guanylin  74 vCEiCa 79 
                  CE+C+
  EFC38784.1 462 ECEMCV 467
                 599998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1563  (0.0871772); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.47
# Mc/sec: 3223.94
//
Query:       EFC38785.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.2e-25   88.1  23.5    6.2e-25   88.1  23.5    1.4  2  TRAM_LAG1_CLN8  TLC domain
  ------ inclusion threshold ------
      0.069   13.3   1.4       0.39   10.8   0.0    2.5  3  UPF0242         Uncharacterised protein family (UPF0242) N-te
       0.18   10.5  12.4        9.8    4.8  12.3    2.2  1  DUF2207         Predicted membrane protein (DUF2207)


Domain annotation for each model (and alignments):
>> TRAM_LAG1_CLN8  TLC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.3       1.7     1e+04       6      19 ..      52      65 ..      49      77 .. 0.68
   2 !   88.1  23.5     1e-28   6.2e-25       1     197 [.      90     279 ..      90     280 .. 0.86

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 1.7
  TRAM_LAG1_CLN8  6 vvslvqyllstvfg 19
                    v sl++++l+ ++g
      EFC38785.1 52 VLSLIFHSLMYAYG 65
                    56677777776666 PP

  == domain 2  score: 88.1 bits;  conditional E-value: 1e-28
  TRAM_LAG1_CLN8   1 kfdervvslvqyllstvfglivlssspelwegyperilgathfllkayyllalgYfiydllvlllyekkrkdfvemliHhiitlvllvlsyvrnl 95 
                     +++ r+vs ++++ls++++l++++    l +  +  il+ +  +  +++ + +gYf+ydl+++  ++ + +  +e ++Hh i++v l+ s+v   
      EFC38785.1  90 EWNSRIVSNIHAILSSLISLYCIVFVY-LPS-PNVGILSLSDRSCIFLIGYCVGYFLYDLYIVARNYPHLGG-METVLHHSISIVALLGSAVWEK 181
                     69******************8887776.222.244566777788888**********************985.9********************* PP

  TRAM_LAG1_CLN8  96 grvglvvlllhelsdpflnlrkilsylkkkskssklvlfngllfllsFfvcRlvllpylillsildvaklslstap.lwlpliflilllv..Lql 187
                     + v +v+++  e+s+pf+n r ++s++ ++ k skl+++ng+l+ l+F ++R+  ++y i + ++++     +  + ++l +i+l+ l++  +++
      EFC38785.1 182 CIVLMVIMMFTEISTPFVNQRYFFSKC-NM-KDSKLYAYNGILMWLTFGIVRISFCFY-IPHLVWEDSE--TW--CsFPLGWIILVTLMIgsICI 269
                     ***************************.99.999*******************99966.7777776665..33..226777777766666579** PP

  TRAM_LAG1_CLN8 188 lnlyWfyliv 197
                     ln++Wfy+i 
      EFC38785.1 270 LNIFWFYKIT 279
                     ********95 PP

>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1       0.2   1.2e+03      38      61 ..      43      66 ..      17     102 .. 0.61
   2 ?   -0.8   0.5      0.23   1.4e+03       4      39 ..     102     137 ..      99     147 .. 0.80
   3 ?   10.8   0.0   6.5e-05      0.39      30     107 ..     246     331 ..     223     338 .] 0.69

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.2
     UPF0242 38 iGlllaaaGsLlllllllkwekal 61
                +Glll ++  L l++  l +    
  EFC38785.1 43 FGLLLPVMSVLSLIFHSLMYAYGS 66
                788888777776666444442222 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.23
     UPF0242   4 llisiiflYllPllllaiysiqllseqksWsllsiG 39 
                 +l s i lY +  + l++ ++++ls ++   ++ iG
  EFC38785.1 102 ILSSLISLYCIVFVYLPSPNVGILSLSDRSCIFLIG 137
                 566778899999999999999999988888888887 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 6.5e-05
     UPF0242  30 qksWsllsiGl...llaaaGsLlllllllkwekalkekl.......ekskleekeaklteldeglktkeealeelqeeeeeLkeelda 107
                 ++ W  + +G      +++Gs+++l ++  ++  + + +       + s +++  +  +  d  +++ke++  e  ++e+eL e+++ 
  EFC38785.1 246 SETWCSFPLGWiilVTLMIGSICILNIFWFYKITMGL-VqvvfakkQPSSVPSTSSTPSTPD-RINVKEKKCDEDDDDERELDEKVAT 331
                 5678888888744355789999888777666555544.324455555555555555555555.9******************999875 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8  12.3    0.0016       9.8     367     433 ..     199     278 ..      57     285 .. 0.94

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0016
     DUF2207 367 kergyfdkkgkkklkklsalglgliilglilillallllvll.............lvfllilllillliaiivlllfsrl 433
                 ++++yf +k++ k  kl a++ +l++l + ++ +++++++++             l ++ +++l+++ i+i+ +++f+++
  EFC38785.1 199 VNQRYFFSKCNMKDSKLYAYNGILMWLTFGIVRISFCFYIPHlvwedsetwcsfpLGWIILVTLMIGSICILNIFWFYKI 278
                 6789****************************9999999999**********9999999999999999999999998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1065  (0.059401); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 2213.20
//
Query:       EFC38786.1  [L=519]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.82    8.9  40.3        1.2    8.5  40.3    1.2  1  BUD22     BUD22


Domain annotation for each model (and alignments):
>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  40.3   6.5e-05       1.2      32     272 ..     256     517 ..     239     519 .] 0.63

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 6.5e-05
       BUD22  32 k.......ekkskklerleeelealKslDleqiAekilaskllktkklaeseelpealks...ikdkkpksnpeekneelektkalenvtsrLlnsktv 120
                         ++ + +l+ l+++ e+lKs+           s + ++kk     ++++++++   i+++ p+  ++ ++ + e+++++++ + + + ++ v
  EFC38786.1 256 TnpnmqisSEWQTTLATLKQDFEKLKSC-------SESLSDFSEEKKNSVYCHVQKNIWKkivIENEPPEADESDSEGNKEDNNKIKKNNTKRMEREIV 347
                 4444555555666777777777777777.......5566666666666666688999999988888888888887788888888888888888999999 PP

       BUD22 121 kevveeive..svkkllgiek.kkkkkeeekkkkkkkkkkkkkkeeeeeeesdkeeesedsed...........eekeeseddeeeeeededdedaee. 204
                 k + ++      +  +l+i k + + ++ + +k+   ++++++ +e++ e+ d+++e+ ++++           +++++++ +eeeee d ++e++e+ 
  EFC38786.1 348 KMERKNTHLkkMMIHRLNIAKiNGTLNDINLRKEIGLEEEEENYDEQD-ENYDEQDENIEEDEevfeiikirkiRKDRDEQVEEEEEEYDGEEEEDEDi 445
                 988776655225577777777877888888888888888888888888.55555555555555699999999874445555555555555555555557 PP

       BUD22 205 .deedeeaeerelaqydgllasddeded.....eyneetdeesseesdssdssesasesesessek.....kkkkkkkk 272
                    +d+e+ee+el+++++    d+ede      ++n+++dee+++e+ +     + +ese+e++e+     +   k+kk
  EFC38786.1 446 vIYDDKEDEEDELEEFEE----DEEDERveiiyNDNNDDDEEEEDENVNIVIYGE-EESEEEEEEEivkpiR--RKNKK 517
                 845578888999999977....666666779654444444444444444444433.3333333333444221..22222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (519 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2497  (0.139272); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.08u 0.34s 00:00:01.42 Elapsed: 00:00:00.56
# Mc/sec: 2812.63
//
Query:       EFC38787.1  [L=136]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      2e-05   24.5  59.7    0.00043   20.3  36.5    2.1  2  Trypan_PARP    Procyclic acidic repetitive protein (PARP)
  ------ inclusion threshold ------
        6.8    5.3  15.9        6.5    5.4  15.9    1.1  1  Presenilin     Presenilin


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3  36.5   4.8e-08   0.00043      45     111 ..      35     101 ..       2     101 .. 0.61
   2 !   14.8  37.4   2.4e-06     0.022      59     111 ..      77     129 ..      74     134 .. 0.46

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 4.8e-08
  Trypan_PARP  45 kgtkvsdddtngtdpepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                    t+ + +    t+++p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC38787.1  35 TQTQTQTQTQTQTQTQPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 101
                  3344444444455666666666666666666666666666666666666666666666666666655 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 2.4e-06
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p
   EFC38787.1  77 PKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP 129
                  33444444444444444444444444444444444444455555555555544 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4  15.9   0.00072       6.5     235     293 ..       7      60 ..       1     120 [. 0.40

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.00072
  Presenilin 235 seeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaeesseek 293
                 ++++++++++++++++++++++++++++     ++++++++++++++++ +++ + ++k
  EFC38787.1   7 AQTQTQTQTQTQTQTQTQTQTQTQTQTQ-----TQTQTQTQTQTQTQTQPKPKPKPKPK 60 
                 2222222222221111111111111111.....11111111111111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3685  (0.205533); expected 358.6 (0.02)
Passed bias filter:                     1089  (0.0607396); expected 358.6 (0.02)
Passed Vit filter:                       282  (0.0157287); expected 17.9 (0.001)
Passed Fwd filter:                        80  (0.00446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.12u 0.41s 00:00:01.53 Elapsed: 00:00:00.56
# Mc/sec: 735.27
//
Query:       EFC38788.1  [L=434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.022   15.7   0.0      0.081   13.8   0.0    1.9  1  Trypsin_2  Trypsin-like peptidase domain
       0.17   12.9   0.2         30    5.8   0.0    2.5  2  DUF3298    Protein of unknown function (DUF3298)


Domain annotation for each model (and alignments):
>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   9.1e-06     0.081       1     140 [.      89     312 ..      89     320 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 9.1e-06
   Trypsin_2   1 GsGflvgsdglilTnaHvv.............................dsadgaavkaikkkveeagadgrevpakvvaadp................. 53 
                 G++f++ ++  ++Tn Hv                              +                                                  
  EFC38788.1  89 GTCFYLLPNV-VITNSHVAntdeipliytgtyseavegyfqklnpvesK--------------------------------Llfsgssmqhqmrkynhs 154
                 89999****9.********555555555444444444333333333220................................233333334444444444 PP

   Trypsin_2  54 ........................el.DlAllkv.ssderaglpplplgpsealkggepvyvvGyplggeksg.svssGivsgvve............. 112
                                         ++ D+ l k+  ++   +  +l + + e l++++p++ + yp+ ++ ++ s++s+++s + +             
  EFC38788.1 155 ltrthfpqvdetyldpiislrgdfGYmDISLHKIaFPNNMQSSKVLMIPCPEILQVSDPIFTMHYPGVEGTQFsSLHSNQFSNYLHwapndnvvsdlfh 253
                 4444445566666666777766555589999999855556666677777888999999*******9554444454444444444444444444444444 PP

   Trypsin_2 113 ...............................sesaasgegesflqtdaatspGsSGGpl 140
                                                ++++ + ++++fl t+ ++  GsSGG +
  EFC38788.1 254 gygklcistgkvlapyveekqengnidwvpnTSHQYNSQNSNFLITNESVTIGSSGGCV 312
                 5555555555555555599999999999999888899999999988888888****987 PP

>> DUF3298  Protein of unknown function (DUF3298)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0    0.0033        30      27      61 ..     272     305 ..     232     306 .. 0.81
   2 ?    4.6   0.0    0.0075        68      16      39 ..     343     366 ..     337     390 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0033
                 CH-TTS-HCCCCTTTTTSS-TTTSSEEEETTEEEE CS
     DUF3298  27 ekqqedeyaglperrdkedilgyqnfyltddglvi 61 
                 ekq++++ +++p+    ++ ++++nf +t+++++i
  EFC38788.1 272 EKQENGNIDWVPN-TSHQYNSQNSNFLITNESVTI 305
                 4555666666666.57788899**********987 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0075
                 HHHHHHHHHHTCH-TTS-HCCCCT CS
     DUF3298  16 kiikeqikkenekqqedeyaglpe 39 
                 k+  + ik+++++++edey+ l  
  EFC38788.1 343 KNCLKHIKQQMNENDEDEYPSLFQ 366
                 778899*****9999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       551  (0.0307323); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.25s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2703.97
//
Query:       EFC38789.1  [L=676]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-23   81.5  12.1    2.3e-13   49.8   5.2    2.9  3  MFS_1     Major Facilitator Superfamily
    2.3e-10   39.6  29.8    2.2e-09   36.4   1.6    3.6  4  MFS_2     MFS/sugar transport protein
     0.0012   17.9   7.0      0.074   12.0   0.0    3.0  3  PUCC      PUCC protein


Domain annotation for each model (and alignments):
>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.1   1.4   4.5e-12   2.7e-08     192     317 ..     114     247 ..      72     260 .. 0.76
   2 ?    0.2   0.0     0.045   2.7e+02     158     189 ..     287     324 ..     282     390 .. 0.75
   3 !   49.8   5.2   3.9e-17   2.3e-13       1     187 [.     462     664 ..     398     673 .. 0.82

  Alignments for each domain:
  == domain 1  score: 33.1 bits;  conditional E-value: 4.5e-12
       MFS_1 192 gpaplvpawkallkdpvlwillialllfffgfsglltllplylqevlglsglllaglllallalvgailallagrlsdr....lgrrrrlllallllll 286
                 +++ l+p  k+  k + ++ + +++ +  fg+++  +ll+ y    lgls   l++l+   + + g+i+++l+g lsdr    lg+rr+ l+ + ++++
  EFC38789.1 114 EEKMLKP--KKASKMRIFL-ATACFSGLQFGWALQIALLTPY-ILELGLS-KNLITLIWLCGPVSGLIIQPLVGVLSDRckspLGKRRPFLIVGTIMIV 207
                 3444444..6667777554.6666777788888888888888.*******.566666699999999999***********9999999999999999999 PP

       MFS_1 287 aalglallavt........ssavllllvlvliGf.glgfv 317
                 ++l+l+++++         ++ + ++++l++iGf  l ++
  EFC38789.1 208 MSLLLIPFSLDlghamgdpTNDHPAAIALAIIGFwILDLF 247
                 9999999999987777777555555668899998666655 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.045
       MFS_1 158 aivsllafvlfllllpeepperkrkspkeee......k 189
                  i++ll+  ++ ll  +e+p++k+ +++++e      +
  EFC38789.1 287 SIMFLLFTFVVTLLAAREEPTHKKHTQRRDEenrligE 324
                 44555555556777788888888888888754544440 PP

  == domain 3  score: 49.8 bits;  conditional E-value: 3.9e-17
       MFS_1   1 lllaaflsalarsilgpalplalaed.................lgispseigllltlyalgaavaslplGrlsdrfGrrrvlllglllfalglllll.f 81 
                 ++++ f+s+l+++++++ ++ +++e+                  g++    ++ l+++a  ++++s+ + +l  ++G + +++++ l++a + l ++ f
  EFC38789.1 462 VCIVNFFSYLGWFTFLVYITTWVGENvfhgksdekepsynlyvKGVQF--GSFGLAGFAGSSIIFSFMIPSLCHKIGFKATFFFSQLVLAGC-LGATlF 557
                 57999***************8888888766666666665543322333..344558888899******************************.555557 PP

       MFS_1  82 a.sslw.lllvlrvlqGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllgglla..sslgWravfyilaivsllafvlfllllpeep 176
                 + + +  lll++ +  G+  ++++++  al+a +++k+++g  +gll++++ +  ++   +g++++  s+++  ++ +  ai  l+++v ++++l  +p
  EFC38789.1 558 VkNKILaLLLISTF--GFPWAVSNTIPFALVATIANKDQKGTFMGLLNIFIVVPQLVMSSFGPVISilSNGNVAWTLMCGAISVLISAV-MVWFLIIPP 653
                 76666655555555..777799*****************************************99963444477776666666666666.457777777 PP

       MFS_1 177 perkrkspkee 187
                 +   +k+ k++
  EFC38789.1 654 SILITKKRKKK 664
                 66666666555 PP

>> MFS_2  MFS/sugar transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.4   1.6   3.7e-13   2.2e-09      16      95 ..     144     231 ..     135     256 .. 0.80
   2 ?   -2.6   0.8      0.25   1.5e+03     213     252 ..     445     482 ..     443     489 .. 0.72
   3 !   16.9   8.3     3e-07    0.0018     261     347 ..     509     594 ..     499     623 .. 0.83
   4 ?    0.9   0.5     0.021   1.3e+02     151     189 ..     613     649 ..     592     674 .. 0.53

  Alignments for each domain:
  == domain 1  score: 36.4 bits;  conditional E-value: 3.7e-13
       MFS_2  16 latylliFytdvlglsaalvglvllvarlvDaitDpivGtlidktstrwGrrrPwlllsaiilavsiillftppelsqs........a 95 
                 l++ ll+ y   lgls  l++l+ l   +  +i+ p+vG+l+d+++  +G+rrP+l +++i++++s++l+ ++++l+ +        +
  EFC38789.1 144 LQIALLTPYILELGLSKNLITLIWLCGPVSGLIIQPLVGVLSDRCKSPLGKRRPFLIVGTIMIVMSLLLIPFSLDLGHAmgdptndhP 231
                 4444555566677*********************************************************999998887777765542 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.25
       MFS_2 213 lleqlkevfrnraflillllfllaalalgvlnglllYylt 252
                 l++ ++++f+ +++++ +++  +++++++ +++ l+Y  t
  EFC38789.1 445 LWNYVRSCFSLPQAMWRVCI--VNFFSYLGWFTFLVYITT 482
                 67788999999999998765..566666778877777665 PP

  == domain 3  score: 16.9 bits;  conditional E-value: 3e-07
       MFS_2 261 asvfllvv.tisallgiplwqplakrlgkkntyllgalltivllvlvlllqpsnlllflvllviagfgvgvaallpwsmladvvDyge 347
                 +  f l+    s+++++++++ l+ ++g k+t+++++l+++  l  +l++  +n +l+l+l   +gf+ +v++++p +++a+++  ++
  EFC38789.1 509 FGSFGLAGfAGSSIIFSFMIPSLCHKIGFKATFFFSQLVLAGCLGATLFV--KNKILALLLISTFGFPWAVSNTIPFALVATIANKDQ 594
                 55566666255678***********************9987777777777..788888889999******************998877 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.021
       MFS_2 151 ailafllvlilgglkserkgylifaliialLmll.gviiv 189
                 +   ++++ il+   + + +++++   i++L+ + +v+++
  EFC38789.1 613 MSSFGPVISILS---NGNVAWTLMCGAISVLISAvMVWFL 649
                 333333333333...3566777776666666543033333 PP

>> PUCC  PUCC protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.0   0.0   1.2e-05     0.074      27      77 ..     174     224 ..     152     244 .. 0.73
   2 ?   -1.8   0.0      0.19   1.2e+03     165     206 ..     292     332 ..     280     341 .. 0.63
   3 !    7.1   1.9   0.00039       2.3      78     176 ..     551     647 ..     525     672 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.2e-05
        PUCC  27 vapfraliGfrSDtkr.alGwkRvpyiwlGslalalglaiaplalivlsgkg 77 
                   + ++l+G  SD ++  lG kR p+++ G++++++ l ++p++l + +  g
  EFC38789.1 174 GLIIQPLVGVLSDRCKsPLG-KRRPFLIVGTIMIVMSLLLIPFSLDLGHAMG 224
                 557899**********7888.5669******************986655544 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.19
        PUCC 165 litlvlnvlalWkievkskkkkeekeeeepslleawlklvae 206
                 l t+v++ l++ + e+++kk+++++ ee+  + e+ + ++ e
  EFC38789.1 292 LFTFVVT-LLAAREEPTHKKHTQRRDEENRLIGEETKTENPE 332
                 2344444.4455788888999877777776666666655555 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.00039
        PUCC  78 eaeaaatwaglilaavafllvGlgvslsqTallALladlaeeeerpkvvgllyvmlligivvsaivvgallkdytearLirvvqgvalitlvlnvlalW 176
                    a++++  +ila ++    G+   +s+T   AL+a++a+++++    gll + +++   v +  +g +++ +++ +  + +  + +i+++++ + +W
  EFC38789.1 551 CLGATLFVKNKILALLLISTFGFPWAVSNTIPFALVATIANKDQKGTFMGLLNIFIVVPQLVMSS-FGPVISILSNGNVAWTL-MCGAISVLISAVMVW 647
                 44566788889999999999********************************9999997666553.45566666666655554.345555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (676 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1312  (0.0731775); expected 358.6 (0.02)
Passed bias filter:                      584  (0.0325729); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.81u 0.29s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 3985.37
//
Query:       EFC38790.1  [L=1057]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1057 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2131  (0.118858); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.02u 0.38s 00:00:01.40 Elapsed: 00:00:00.58
# Mc/sec: 5491.61
//
Query:       EFC38791.1  [L=761]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-90  301.6   0.5    5.4e-90  301.1   0.5    1.2  1  Malic_M   Malic enzyme, NAD binding domain
    3.1e-71  238.9   0.0    8.2e-71  237.6   0.0    1.7  2  malic     Malic enzyme, N-terminal domain
     0.0035   17.9   1.0     0.0084   16.7   0.0    2.2  3  Csm1      Chromosome segregation protein Csm1/Pcs1
  ------ inclusion threshold ------
      0.055   13.9   0.2       0.11   13.0   0.2    1.4  1  DUF3796   Protein of unknown function (DUF3796)


Domain annotation for each model (and alignments):
>> Malic_M  Malic enzyme, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  301.1   0.5   1.2e-93   5.4e-90       1     257 [.     457     724 ..     457     725 .. 0.93

  Alignments for each domain:
  == domain 1  score: 301.1 bits;  conditional E-value: 1.2e-93
                 THHHHHHHHHHHHHHHHHH-S-GGG--EEEEC-SHHHHHHHHHHHHHHH....TTTS-HHH....HHTTEEEEETTEE-BTT-...S---TTTGGGSBS CS
     Malic_M   1 iqgTaavalagllaalkitgkklseqkivvlGaGsagiGiaeqivealv....keGlseee....akkkiylvDrkGLltedr...ekleeekkpfakk 88 
                 iqgT+av +ag ++a+kitgk+  ++k++++GaGsa++G+a+q+v  ++    ++Gls+ee    +++ +ylvD+kGL+t++r   e++ ++kk++akk
  EFC38791.1 457 IQGTGAVIVAGFINAAKITGKRTYQHKLLFMGAGSAATGVADQCVGVMKlqaeEDGLSKEEidamSEHWVYLVDSKGLVTQTRsdyEEMPHHKKKYAKK 555
                 9******************************************987764222155****883322345699*********99933345799******** PP

                 --SS--S....SHHHHHHHH--SEEEE-SSSSS-S-HHHHHHHHHHSSS-EEEE--SSGGGSSS-HHHHHHHTTT-SEEEESS----EEETSEEE--EE CS
     Malic_M  89 keelkeakdkltLeevvkkvkptvliGlsgvagafteeivremaksterPiilplSNPtskaEataedvlkwtdgkalvasGsPfkpvelngktyeigQ 187
                  +e+    ++++L+e+v+k +pt+liGl g++g+ft++i++emak +++Pi+++lSNPt+++E+ta+++++++ g+a++asGsPf++v++ngkty+ +Q
  EFC38791.1 556 GDETLGNFQSKSLLEIVQKTQPTALIGLCGQSGVFTQDIIEEMAKINQKPIVFALSNPTKNSECTAKEAIEYSSGRAIFASGSPFEDVTYNGKTYQLSQ 654
                 **999999******************************************************************************************* PP

                 --GGGTHHHHHHHHHHTT-SS--HHHHHHHHHHHHTT--HHHHHTT-SS--GGGHHHHHHHHHHHHHHHH CS
     Malic_M 188 aNNayifPglglgvivarakritdemllaaaealaelvseeelkegsllPelseirevslkvavavakaa 257
                 +NN yifP+lglg++v+r+k+++d m+l aa++la+l+s+++l++g l+P+l++ire+++k+av+v k+ 
  EFC38791.1 655 GNNLYIFPALGLGAVVTRSKHVSDVMILRAAQTLADLTSQDRLDNGLLYPSLTNIREIAQKIAVQVGKQS 724
                 ******************************************************************9975 PP

>> malic  Malic enzyme, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  237.6   0.0   1.8e-74   8.2e-71       1     182 []     267     447 ..     267     447 .. 0.99
   2 ?   -3.2   0.0       1.4   6.3e+03      34      90 ..     541     593 ..     535     599 .. 0.62

  Alignments for each domain:
  == domain 1  score: 237.6 bits;  conditional E-value: 1.8e-74
                 HTTECCCCCCHHCCCHHHHHHHHSTTCHHHHHHHHHHHGGCHHSCCCEGGGETCHHHHHTTSS.SS..EEEEE-SSSBTTTBS-GHHHHHHHHHHHHHH CS
       malic   1 qeknetlfykllkekleellpivYtPtvgeacqeyseeyrkarglylsikdkekikeilknlpeedvkvivvtdgeriLGlGdlGvagvgimvGKlaLy 99 
                 q++n+tlf+kll +++ e+lpivYtPtvg+ac ++ +++r a+g+y+s +dk++i+ ilkn++ ++ ++ivv+dg+riLGlGdlG++g+gi++GKl Ly
  EFC38791.1 267 QGRNQTLFFKLLIDNMVEMLPIVYTPTVGDACLQFDQIWRVAQGMYISLEDKGSISAILKNWEPKQPDIIVVSDGSRILGLGDLGANGMGIPIGKLNLY 365
                 689************************************************************************************************ PP

                 HHHHS-EGGGEEEEEECS-BS.HHHHC.TT..S.SSB...SHHHHHHHHHHHHHHHHHHGCTSEEEE-S--CCHHHHHHHHHC CS
       malic 100 talagidPekvlpvvldvgtnneelledplYlGlrkkRvkgeeydefvdefveavkelfppkaliqfEDfkaknafeileryr 182
                 +a+ag++P+k+lp+++dvgtnn  lled+lYlGl++kRv+g+e+ +f++ef+ avk+++ p++l+qfEDf+++ +f++l++yr
  EFC38791.1 366 VAAAGFHPDKTLPICIDVGTNNPGLLEDDLYLGLKRKRVRGQEFFDFMKEFMIAVKTTW-PNCLVQFEDFSNDVCFDLLDQYR 447
                 ***********************************************************.**********************8 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.4
                 HHHHHGGCHHSCCCEGGGETCHHHHHTTSS.SS...EEEEE-SSSBTTT.BS-GHHHHH CS
       malic  34 eyseeyrkarglylsikdkekikeilknlpeedv.kvivvtdgeriLGl.GdlGvagvg 90 
                 +y+e +++++ +y +++d+     +l n++++++ +++  t  ++ +Gl G  Gv   +
  EFC38791.1 541 DYEEMPHHKK-KYAKKGDE-----TLGNFQSKSLlEIVQKTQPTALIGLcGQSGVFTQD 593
                 5555555555.66666666.....78888855541555568888888875666665555 PP

>> Csm1  Chromosome segregation protein Csm1/Pcs1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       2.7   1.2e+04      51      63 ..     204     216 ..     191     236 .. 0.70
   2 !   16.7   0.0   1.9e-06    0.0084      16      59 ..     251     294 ..     238     303 .. 0.89
   3 ?   -4.1   0.1         4   1.8e+04      26      81 ..     439     453 ..     431     454 .. 0.51

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.7
        Csm1  51 aeisYvPlldesr 63 
                 +++ Y P+l++++
  EFC38791.1 204 NHFLYNPMLNKDT 216
                 6789999987554 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 1.9e-06
        Csm1  16 rsvkedesedvfdciqtgrngtlhfkLaiskefeeaeisYvPll 59 
                 r++k+  +++v+ ++ +grn+tl fkL i++  e   i+Y+P++
  EFC38791.1 251 RNFKNPLDKYVYLMSLQGRNQTLFFKLLIDNMVEMLPIVYTPTV 294
                 78899999***********************9999*******96 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 4
        Csm1  26 vfdciqtgrngtlhfkLaiskefeeaeisYvPlldesrdkellelLPdYLveeitF 81 
                  fd++ +                                         Y  e+++F
  EFC38791.1 439 CFDLLDQ-----------------------------------------YRNEQLCF 453
                 4444444.........................................44455544 PP

>> DUF3796  Protein of unknown function (DUF3796)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   2.4e-05      0.11      30      85 ..       7      62 ..       1      73 [. 0.83

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.4e-05
     DUF3796 30 ffaFfaffsfffvaklstvllDErfeenvkraaaiafkvaileiiiavlislilsr 85
                 + Ff+ +s +   k+  +   E fe++ +   a +f++ i ++i+a++++   s+
  EFC38791.1  7 LLLFFVCYSWYSSFKILAIAPNENFEKSLQYRNASSFQFHIKSSILAACLNSHHSN 62
                55677777777777************************************987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (761 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       993  (0.0553851); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.52
# Mc/sec: 4429.92
//
Query:       EFC38792.1  [L=337]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.8e-18   64.7   0.2    9.2e-18   64.2   0.2    1.1  1  p450      Cytochrome P450
  ------ inclusion threshold ------
      0.067   12.7   0.0       0.16   11.5   0.0    1.5  1  DUF4290   Domain of unknown function (DUF4290)


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.2   0.2     1e-21   9.2e-18      37     276 ..      96     336 ..      86     336 .. 0.84

  Alignments for each domain:
  == domain 1  score: 64.2 bits;  conditional E-value: 1e-21
                 EEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESS.HHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHHTSHSTT.THHHHHHHHHHHHH.HHHHCC CS
        p450  37 frlklgskpvvvlsgpeavkevlikkgeefsgrpd.eallatsrkpfkgkgvlfangekwkklRrfltptltsfgkl.sleelveeeaedlv.eklrkk 132
                  r+    ++  v+ + ++vkevl++k+++f +  d +  +++  + + +  +  a+g+ wk++R+++ p++ ++ +l  + +++ + ++ l  +k++k 
  EFC38792.1  96 IRVSTPYRNNYVIWDKDSVKEVLVTKSSSFPKPLDfYEPFNI-FDKDATSILTAADGPVWKNHRHVVAPSFSTG-NLvFMSQVTVKTVDALFrTKWNKL 192
                 5666667888999*************7544443321333443.33566677788888*****************.998999998888887652689999 PP

                 CCHCS..EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHHHHHCHHHHCCCCCH.HHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHH CS
        p450 133 agess..elditellskaaldvigsilFgarfdlledeklselvkaveelssllskssvqllllfp.llkylptkllrklkeavkklkdlldklieerr 228
                  ++ s   +   e+ + ++l +ig+  Fg+ f+ + de +s+ +k+ e+l+ ++  + +  ++l +  ++y   +++    ea k++++ l+++i +r 
  EFC38792.1 193 LDQDSkgFIMDMEDTTAVTLQIIGESGFGMDFG-VFDETSSDSKKFREALNIVVRVDYYARFFLAKiPFLYNAVSDYTGNTEALKVMSEKLEQCISQRV 290
                 9999988666678899*****************.9999999*********9999888887777777789999*************************** PP

                 HCHCHC.SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHH CS
        p450 229 etldsa.kksrrdfldalllakkekkgesklsdeelaatvlellfaGvd 276
                 ++++++ +k  +d+l++l++a  + ++  kl+ +el+ +   + +aG++
  EFC38792.1 291 AEFKQDpEKPMNDLLSLLVKAN-MMDE--KLTLNELKSNSYIFVVAGHE 336
                 ******8888999999999995.4444..6*****************97 PP

>> DUF4290  Domain of unknown function (DUF4290)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   1.7e-05      0.16     111     157 ..      74     120 ..      66     123 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1.7e-05
     DUF4290 111 nieeliekaleleegeerealvklianqmkksylqwnkdsvddekil 157
                 +i+ li k  e  +g++ ++l++ + +  +++y+ w+kdsv++  ++
  EFC38792.1  74 VIQGLIAKEEERAKGSDEKQLIIRVSTPYRNNYVIWDKDSVKEVLVT 120
                 58999************************************998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (337 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       798  (0.0445089); expected 358.6 (0.02)
Passed bias filter:                      631  (0.0351944); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 1971.84
//
Query:       EFC38793.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.057   13.7   0.6       0.11   12.8   0.6    1.8  1  UPF0203   Uncharacterised protein family (UPF0203)


Domain annotation for each model (and alignments):
>> UPF0203  Uncharacterised protein family (UPF0203)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.6     6e-06      0.11      15      48 ..      40      74 ..      33     116 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 6e-06
     UPF0203 15 deCFnkWfsekflk..gkekeeeCeklwkkYreClk 48
                 eCFn+W+ e+  k  ++++++  ++ + ++ e ++
  EFC38793.1 40 AECFNSWY-ENVSKhlIDWSSKAVSNRFAEFTELVD 74
                58******.766666678888888888888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       975  (0.0543812); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.46
# Mc/sec: 763.49
//
Query:       EFC38794.1  [L=724]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.5e-20   70.5   9.6    2.3e-07   30.9   0.4    3.8  3  Myb_DNA-binding  Myb-like DNA-binding domain
    3.1e-19   69.0  11.1    1.4e-06   28.5   1.1    3.7  3  Myb_DNA-bind_6   Myb-like DNA-binding domain
     0.0031   17.7   5.5        1.4    9.1   0.0    3.7  3  SANT_DAMP1_like  SANT/Myb-like domain of DAMP1
  ------ inclusion threshold ------
      0.087   12.8   0.6         12    5.9   0.0    3.1  3  MVP_shoulder     Shoulder domain


Domain annotation for each model (and alignments):
>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   0.4     8e-11   3.6e-07       1      46 []       3      47 ..       3      47 .. 0.95
   2 !   13.7   0.2   1.2e-05     0.056       4      45 ..      57     101 ..      54     112 .. 0.85
   3 !   30.9   0.4   5.1e-11   2.3e-07       4      43 ..     119     159 ..     116     161 .. 0.95

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 8e-11
                     CSSSBHHHHHHHHHHHHHHTTCHHHHHHHHTSS-HHHHHHHHHHHT CS
  Myb_DNA-binding  1 rgkWteeEdelLleavkkhGnrWkkIaerlggRtekqcrsrwrnyl 46
                     r++W +eE++lL+++vk+ G +W++Ia  +   t+++c  +++++l
       EFC38794.1  3 RKNWLKEEEDLLVKLVKEKGHNWTEIAPNF-DVTPNACHKKYKDLL 47
                     789***********************9999.79*********9876 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1.2e-05
                      SBHHHHHHHHHHHHH...HT.TCHHHHHHHHTSS-HHHHHHHHHHH CS
  Myb_DNA-binding   4 WteeEdelLleavkk...hG.nrWkkIaerlggRtekqcrsrwrny 45 
                      Wt e   +Ll++ k+    G ++Wk I e+l g+ +k+c+ +++ +
       EFC38794.1  57 WTDEMKANLLKLAKEyadKGiEKWKIIEEKL-GKEAKACQQHFYYL 101
                      78888888888888855567888********.6**********975 PP

  == domain 3  score: 30.9 bits;  conditional E-value: 5.1e-11
                      SBHHHHHHHHHHHHHHTTCHHHHHHHHT.SS-HHHHHHHHH CS
  Myb_DNA-binding   4 WteeEdelLleavkkhGnrWkkIaerlg.gRtekqcrsrwr 43 
                      Wt eE   L e+v++hG +WkkI + +  +R + +c+s + 
       EFC38794.1 119 WTMEEKRELTELVNLHGRKWKKIEKLIScNRDAHSCQSQFM 159
                      **************************************985 PP

>> Myb_DNA-bind_6  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.1   3.4e-09   1.5e-05       1      45 [.       6      48 ..       6      56 .. 0.90
   2 !   20.6   0.4   8.6e-08   0.00039       1      43 [.      57     101 ..      57     114 .. 0.88
   3 !   28.5   1.1   3.1e-10   1.4e-06       1      43 [.     119     161 ..     119     175 .. 0.86

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 3.4e-09
  Myb_DNA-bind_6  1 WteeEdeiLlklvekygndWknIaealnrRtpkqcfdrwknkLrp 45
                    W +eE+++L+klv++ g +W++Ia  +   tp++c  ++k  L  
      EFC38794.1  6 WLKEEEDLLVKLVKEKGHNWTEIAPNFD-VTPNACHKKYKD-LLK 48
                    889************************9.9**********9.543 PP

  == domain 2  score: 20.6 bits;  conditional E-value: 8.6e-08
  Myb_DNA-bind_6   1 WteeEdeiLlklvekygn....dWknIaealnrRtpkqcfdrwknkL 43 
                     Wt+e +  Llkl ++y +    +Wk I+e l+ + +k+c++++ + L
      EFC38794.1  57 WTDEMKANLLKLAKEYADkgieKWKIIEEKLG-KEAKACQQHFYY-L 101
                     ****************7667789*********.**********98.5 PP

  == domain 3  score: 28.5 bits;  conditional E-value: 3.1e-10
  Myb_DNA-bind_6   1 WteeEdeiLlklvekygndWknIaealn.rRtpkqcfdrwknkL 43 
                     Wt eE+++L +lv  +g++Wk+I++ ++ +R++ +c+  +   L
      EFC38794.1 119 WTMEEKRELTELVNLHGRKWKKIEKLIScNRDAHSCQSQFML-L 161
                     ***************************889*******99865.4 PP

>> SANT_DAMP1_like  SANT/Myb-like domain of DAMP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0   0.00032       1.4      27      58 ..       4      35 ..       1      41 [. 0.88
   2 !    7.0   0.4    0.0015       6.7      17      46 ..      40      74 ..      31      99 .. 0.76
   3 ?    2.5   0.2     0.038   1.7e+02      27      52 ..     117     142 ..      95     164 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00032
  SANT_DAMP1_like 27 edWtkeetdyLfdlckeydlrfvviaDryele 58
                     ++W kee d L++l+ke    ++ ia +++++
       EFC38794.1  4 KNWLKEEEDLLVKLVKEKGHNWTEIAPNFDVT 35
                     79***********************9999985 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0015
  SANT_DAMP1_like 17 deeYeellke.....edWtkeetdyLfdlckeydl 46
                     +++Y+ llk+     + Wt e    L++l+key  
       EFC38794.1 40 HKKYKDLLKNlgrkrSFWTDEMKANLLKLAKEYAD 74
                     68999999998875445****************64 PP

  == domain 3  score: 2.5 bits;  conditional E-value: 0.038
  SANT_DAMP1_like  27 edWtkeetdyLfdlckeydlrfvvia 52 
                      + Wt ee + L +l++    ++  i 
       EFC38794.1 117 PFWTMEEKRELTELVNLHGRKWKKIE 142
                      34**************9999998776 PP

>> MVP_shoulder  Shoulder domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.014        63      29      65 ..     404     436 ..     398     446 .. 0.73
   2 ?   -3.3   0.0         2   8.8e+03      89     107 ..     595     613 ..     586     616 .. 0.73
   3 ?    5.9   0.0    0.0028        12      10      64 ..     640     694 ..     633     702 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.014
                   E---SSHHHHHHCCCHSSHHHHHHHHHHHHHHHHHHT CS
  MVP_shoulder  29 FevdkkdeeeaeklFsvedfvgdackalasriRgava 65 
                   F    ++++e+e ++   df++++c+     iR+  +
    EFC38794.1 404 F----NAKNEQELTYYFTDFLKEICELNSETIREDLK 436
                   3....4556666667778********99999999776 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2
                   ---EESS-EEETTTTEEEE CS
  MVP_shoulder  89 eegkvrkellfeennlvit 107
                   e++kv+ +++f+ +nl+++
    EFC38794.1 595 EKKKVNADVVFRPFNLTVQ 613
                   4677899999999999986 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0028
                   EEE-TTSEEEEEEEGGCEEE---SSHHHHHHCCCHSSHHHHHHHHHHHHHHHHHH CS
  MVP_shoulder  10 evetadharLqlklsynweFevdkkdeeeaeklFsvedfvgdackalasriRgav 64 
                    v+  d   ++ k++y +++e+++ d+ e++++F ++ +++ +        R+av
    EFC38794.1 640 IVQNVDTDLVSAKICYGNRWEIREMDNYESAATFCLKKYIASLGFPSDRMTRNAV 694
                   677788888999**********99****************987655555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (724 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       738  (0.0411624); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.71u 0.32s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 4207.97
//
Query:       EFC38795.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-34  118.1   0.1    4.5e-34  118.0   0.1    1.0  1  p450      Cytochrome P450
  ------ inclusion threshold ------
       0.11   12.5   0.0       0.24   11.5   0.0    1.6  1  PAS_8     PAS domain
       0.15   12.4   0.0        1.6    9.1   0.0    2.4  3  QueF_N    Nitrile reductase, 7-cyano-7-deazaguanine-reductase


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.0   0.1   7.5e-38   4.5e-34     282     456 ..       1     184 [.       1     192 [. 0.89

  Alignments for each domain:
  == domain 1  score: 118.0 bits;  conditional E-value: 7.5e-38
                 HHHHHHHHHHSHHHHHHHHHHHHHHCCTTT...T-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTS CS
        p450 282 lswaLyeLaknPevqeklreEidevlgdkr...eptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevf 377
                 ++w +yeL k+Pe+q+k reE  ++ g++     p++dd +++ y   ++ E LRlhp+v+ ++ + + k ++i+  +ipkG+ + vn+ a+h   e f
  EFC38795.1   1 MQWLMYELSKRPEAQQKAREEAIRIGGGDNvlrAPDFDDYNNMDYIHGCVMECLRLHPPVV-SMVKTCAKSTKIGKTSIPKGSCIYVNAKACHLYGEDF 98 
                 68*******************999995555688****************************.999*****************************99999 PP

                 SSTT....S--GGGGB-TTS.CTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSC..SSEEES CS
        p450 378 pnPe....eFdpeRFldekg.nskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileks..glllpp 456
                 +  e    +F peRFld++  ++ + s a++PF +  R CiG  +A+ el ++l ++Lq +e++l +++++p    +   g++ +p
  EFC38795.1  99 NTTEftgaQFAPERFLDKDFkQKVQTSGAWFPFNMSNRKCIGYMFAQIELCIMLCRMLQFYEFKLLNDESKPAEKVEDlpGITFRP 184
                 877666669*********9865557899*************************************998887765554455555544 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0     4e-05      0.24      21      45 ..      82     103 ..      71     129 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 4e-05
       PAS_8  21 drivdvNqaalellGysadlkgell 45 
                   +++vN +a++l+G  +d+ + ++
  EFC38795.1  82 S-CIYVNAKACHLYG--EDFNTTEF 103
                 4.9************..55665444 PP

>> QueF_N  Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.81   4.9e+03      36      42 ..       3       9 ..       2      15 .. 0.88
   2 ?    9.1   0.0   0.00027       1.6      53     103 ..      72     123 ..      61     126 .. 0.83
   3 ?   -0.0   0.0      0.18   1.1e+03      35      51 ..     155     171 ..     134     178 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.81
                EEEEEEE CS
      QueF_N 36 WtayEls 42
                W +yEls
  EFC38795.1  3 WLMYELS 9 
                99****9 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00027
                 EEEEEEEETTSSEEE-HHHHHHHHHTTTT-B-S-HHHH.HHHHHHHHHHHHT CS
      QueF_N  53 aiaelevpaesenliEsksfklYlnsfnqtrfesaeev.eetlekDlsaaag 103
                  i++ ++p  s   +++k+  lY + fn+t+f+ a+   e+ l kD+++ ++
  EFC38795.1  72 KIGKTSIPKGSCIYVNAKACHLYGEDFNTTEFTGAQFApERFLDKDFKQKVQ 123
                 5788999*************************99875426678888887765 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.18
                 EEEEEEEEEE-TTS-EE CS
      QueF_N  35 iWtayElswLnakgkpq 51 
                 + + yE+  Ln + kp+
  EFC38795.1 155 MLQFYEFKLLNDESKPA 171
                 5678********99996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       432  (0.024095); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.33s 00:00:00.87 Elapsed: 00:00:00.53
# Mc/sec: 1112.81
//
Query:       EFC38796.1  [L=297]
Description: silent information regulator family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.2e-35  122.1   0.0    3.2e-35  121.7   0.0    1.2  1  SIR2          Sir2 family
    0.00051   19.8   0.0       0.39   10.5   0.0    2.4  2  TPP_enzyme_M  Thiamine pyrophosphate enzyme, central domain


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  121.7   0.0   3.5e-39   3.2e-35       1     177 []      34     228 ..      34     228 .. 0.86

  Alignments for each domain:
  == domain 1  score: 121.7 bits;  conditional E-value: 3.5e-39
                 -GGGGGGGT---SSSTTSHHHHSCHHH.HSSHHHHHHHHHHHHHHHHHHHHHHHCC..TSS--HHHHHHHHHHHTT..CEEEEEES-SSSHHHHTT-SS CS
        SIR2   1 GAGiStesGipdfRskeGlyaklakee.laspealfskkllveevfyniarellae..eaepnaaHkalkklekkg..kllrliTQNiDgLekkaGskk 94 
                 GAG+S+esGi +fR+  Gl++ l  +  la   + f  +++ +  + + +++ + +  +a pn+ H al+kle++   + +++iTQN+DgL+++aGs++
  EFC38796.1  34 GAGMSAESGIDTFRGGGGLWTGLMGKLfLAYGGTPFGWNITPQICWGQYIKRFYGPiaKADPNNGHFALAKLEQEVfgDYMEVITQNVDGLHQRAGSTH 132
                 9********************98765537777777777777777788888887766679**************9954599******************* PP

                 EEETTEEEEEEEETTTSBEEECCGGHCHHHCCTT..........B-TTTCCBEEEEE--CTSB-S.HHHHHHHH...HHHH-SEEEEES--STSTT CS
        SIR2  95 vvelHGslakakcvkcekkldkeelqeeieaekvp.........ecekcgkllkpdvvfFGealp.dklkklie...kveeadlllviGtSlkVap 177
                 v+e+HG++++  c++ ++++d +e+  e ++ek+          + + c+++l+pd v+F ealp d+++  ++    +++ d+++++GtS+kV+p
  EFC38796.1 133 VYEVHGTVMRHCCIAERHIFDFDEYWGEENDEKKMdlpdkspkcKHPGCNSTLRPDCVLFTEALPmDQWEPSFHavdRMRKGDVMICVGTSAKVYP 228
                 ************************999988887777889888545556999**************99998655522277889************98 PP

>> TPP_enzyme_M  Thiamine pyrophosphate enzyme, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   4.3e-05      0.39       2      26 ..      17      41 ..      16      47 .. 0.86
   2 !    7.0   0.0   0.00051       4.5      68     117 ..     204     254 ..     173     272 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 4.3e-05
                  HHHHHHHHH-SSEEEEE-CHHCHTT CS
  TPP_enzyme_M  2 ekaaellkaakrpvilvGggvarsg 26
                  e++a+l+++a+r+v++ G g++ + 
    EFC38796.1 17 EHIAQLINKARRVVVFSGAGMSAES 41
                  789*****************99765 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.00051
                   CHHHHHHHHH-SEEEEES-SSSTCCCTTTTT.TTTTT-.EEEEEESSCCCCT CS
  TPP_enzyme_M  68 skaanealeeaDlvlalGarfddirttgsep.efapea.kiihididpaeig 117
                   s +a + +++ D+++++G+  + +  ++  p + a+++  +i+++ ++++ +
    EFC38796.1 204 SFHAVDRMRKGDVMICVGTSAKVYPAAS-LPgRAARRGaHLIEFNLEETDYN 254
                   55688899**********9998866555.44477777778999888777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 1662.49
//
Query:       EFC38797.1  [L=196]
Description: RING-finger domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.2e-09   36.2   5.3    8.5e-09   35.2   5.3    1.5  1  zf-RING_5     zinc-RING finger domain
    2.9e-07   30.7   8.6    6.6e-07   29.6   8.6    1.7  1  zf-RING_2     Ring finger domain
    4.9e-05   23.1   8.2    0.00018   21.3   8.2    2.1  1  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
    9.9e-05   22.1   6.5     0.0001   22.1   4.8    2.0  1  zf-C3HC4_2    Zinc finger, C3HC4 type (RING finger)
    0.00034   20.4   7.6     0.0011   18.8   7.6    1.8  2  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
    0.00058   19.8   0.9    0.00058   19.8   0.9    2.5  2  zf-RING_UBOX  RING-type zinc-finger
     0.0012   18.6   6.4     0.0053   16.5   3.1    2.6  2  zf-RING_11    RING-like zinc finger
  ------ inclusion threshold ------
       0.03   14.2  13.2      0.073   12.9   8.3    2.9  3  Prok-RING_4   Prokaryotic RING finger family 4
      0.049   13.7   5.0       0.29   11.2   4.7    2.1  2  zf-ANAPC11    Anaphase-promoting complex subunit 11 RING-H2 f
        0.5   10.2   5.3        1.4    8.8   5.3    1.8  1  zf-RING_4     RING/Ubox like zinc-binding domain
       0.78    9.9   6.4       0.73   10.0   4.2    2.1  1  RINGv         RING-variant domain
        3.7    7.9  10.7         12    6.3   8.6    2.4  2  zf-rbx1       RING-H2 zinc finger domain


Domain annotation for each model (and alignments):
>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2   5.3   5.7e-12   8.5e-09       1      42 [.      58     102 ..      58     104 .. 0.97

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 5.7e-12
   zf-RING_5   1 hCnkCfeklskeekfyltsCgHifCekClkkll...ekeavCpiC 42 
                 hC++C e + +e +  +++C+H+++++Cl++l+   +k+ +CpiC
  EFC38797.1  58 HCPICLEGVLEEGGNRILACKHFIHDNCLDQLTeihGKNTKCPIC 102
                 9******************************************** PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6   8.6   4.4e-10   6.6e-07       2      43 ..      58     102 ..      57     103 .. 0.89

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 4.4e-10
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreClerwlrssst...CPlC 43 
                  CpICle + ++   ++l C+H++h +Cl+++++ + +   CP+C
  EFC38797.1  58 HCPICLEGVLEEGGNRILACKHFIHDNCLDQLTEIHGKntkCPIC 102
                 6********7777778888************9999888899**** PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   8.2   1.2e-07   0.00018       1      41 []      59     102 ..      46     102 .. 0.95

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 1.2e-07
                 -TTT-S--SS-E...E-TTS--B-CHHHHHHHHC.TSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepn..elleCkHsfCskCirkilks.rkkvkCPlC 41 
                 CpiCle + e+   ++l CkH ++ +C++++++   k++kCP+C
  EFC38797.1  59 CPICLEGVLEEGgnRILACKHFIHDNCLDQLTEIhGKNTKCPIC 102
                 ******99888888*******************9888888**** PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   4.8   6.7e-08    0.0001       2      40 .]      59     102 ..      58     102 .. 0.79

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 6.7e-08
  zf-C3HC4_2   2 CpiCld.mlkdp.svvtpCgHvfCqkCilr..sLeekn.eCPlC 40 
                 CpiCl+ +l+++  ++ +C+H  + +C+++   ++ kn +CP+C
  EFC38797.1  59 CPICLEgVLEEGgNRILACKHFIHDNCLDQltEIHGKNtKCPIC 102
                 *****856777526777************9544556678***** PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.7      0.02        30      35      45 ..      52      64 ..      47      69 .. 0.71
   2 !   18.8   7.6   7.2e-07    0.0011       3      47 ..      57     106 ..      55     107 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.02
                H..TT-B-TTT-- CS
  zf-C3HC4_3 35 k..rkkkCpiCrr 45
                +  ++++CpiC +
  EFC38797.1 52 NysKECHCPICLE 64
                2457899999965 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 7.2e-07
                 SB-TTTSS...SBS-EEETTEEEEEE-HHHHHHHHH...TT-B-TTT--B- CS
  zf-C3HC4_3   3 eeCviCle...rprnvvllpCgHlvlCeeCaekllk...rkkkCpiCrrpi 47 
                   C+iCle   ++    +l C+H+ +  +C+++l +   +++kCpiC +p+
  EFC38797.1  57 CHCPICLEgvlEEGGNRILACKHF-IHDNCLDQLTEihgKNTKCPICVQPV 106
                 67******77668888999*****.99*******99***********9997 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.9   3.9e-07   0.00058       1      39 []      59     100 ..      59     100 .. 0.81
   2 ?    2.2   0.7      0.13   1.9e+02       1       7 [.      99     105 ..      99     110 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 3.9e-07
  zf-RING_UBOX   1 CpICle.lft...dPlvlpCGHtFCreClwelskslegafkCP 39 
                   CpICle +++   +  +l C H ++ +Cl +l++  +++ kCP
    EFC38797.1  59 CPICLEgVLEeggNR-ILACKHFIHDNCLDQLTEIHGKNTKCP 100
                   *****8555566655.558**********77888889999998 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.13
  zf-RING_UBOX   1 CpIClel 7  
                   CpIC ++
    EFC38797.1  99 CPICVQP 105
                   ****885 PP

>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   3.1   3.5e-06    0.0053       2      29 .]      59      86 ..      58      86 .. 0.96
   2 ?    2.6   0.1     0.079   1.2e+02       2      12 ..      99     109 ..      98     112 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3.5e-06
  zf-RING_11  2 CsICLeefkpgqalfilpCsHtFHfkCI 29
                C ICLe + ++   +il C+H  H +C+
  EFC38797.1 59 CPICLEGVLEEGGNRILACKHFIHDNCL 86
                **********99999************5 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.079
  zf-RING_11   2 CsICLeefkpg 12 
                 C IC +++ p+
  EFC38797.1  99 CPICVQPVFPK 109
                 *****998766 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   1.5     0.068     1e+02      29      38 ..      52      64 ..      48      69 .. 0.73
   2 ?   12.9   8.3   4.9e-05     0.073       1      39 [.      59     105 ..      59     111 .. 0.76
   3 ?   -1.0   0.0       1.1   1.6e+03       6      17 ..     156     167 ..     153     170 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.068
  Prok-RING_4 29 dls...sCPlCqr 38
                 ++s    CP+C +
   EFC38797.1 52 NYSkecHCPICLE 64
                 4555568****75 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 4.9e-05
  Prok-RING_4   1 CvlCgeq...ekkailepCgHlvCkeCfdsk.....dlssCPlCqrr 39 
                  C +C e    e   ++  C+H + ++C+d+      +++ CP+C + 
   EFC38797.1  59 CPICLEGvleEGGNRILACKHFIHDNCLDQLteihgKNTKCPICVQP 105
                  66666655557888999************9865555555*****876 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 1.1
  Prok-RING_4   6 eqekkailepCg 17 
                  ++ +  i+e+C+
   EFC38797.1 156 SSTSSQIVESCA 167
                  566788999**8 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.46   6.8e+02      61      78 ..      46      63 ..      40      69 .. 0.78
   2 ?   11.2   4.7    0.0002      0.29      50      80 ..      75     105 ..      56     110 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.46
                HHHHHHHHSTSSB-TTTS CS
  zf-ANAPC11 61 ilkwletetskglcpmcr 78
                + k l++ + + +cp+c 
  EFC38797.1 46 VSKMLKNYSKECHCPICL 63
                567788888888999995 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.0002
                 BTTS-EEEHHHHHHHHHHHSTSSB-TTTSSB CS
  zf-ANAPC11  50 Gkckhnfhlhcilkwletetskglcpmcrqt 80 
                   ckh +h+ c+ +  e +  + +cp+c q 
  EFC38797.1  75 LACKHFIHDNCLDQLTEIHGKNTKCPICVQP 105
                 47**************************996 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   5.3   0.00095       1.4       1      45 [.      59     104 ..      56     106 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00095
   zf-RING_4   1 cplCdeel.detdkdlkpCeCgyqiClfCyhrile..eeegrCPaCre 45 
                 cp+C e + +e ++++  C  ++ i   C++++ e   ++ +CP C +
  EFC38797.1  59 CPICLEGVlEEGGNRILAC--KHFIHDNCLDQLTEihGKNTKCPICVQ 104
                 9****99879999999876..5667667777666654689******65 PP

>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   4.2   0.00049      0.73       1      48 []      59     102 ..      59     102 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00049
                 ETTTTEE-SSSS.--B-SS--STCCCSB-HHHHHHHHHHTCT-SB-TTT CS
       RINGv   1 CriCleeeeese.plispCkCrGslklvHesClekWldekeantqCeiC 48 
                 C iCle+  e+  + i  Ck     +++H +Cl++  + + +nt+C iC
  EFC38797.1  59 CPICLEGVLEEGgNRILACK-----HFIHDNCLDQLTEIHGKNTKCPIC 102
                 67777776666555555555.....79********999999******** PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.9      0.92   1.4e+03      48      54 ..      56      62 ..      46      63 .. 0.70
   2 ?    6.3   8.6     0.008        12      31      54 ..      76     102 ..      59     103 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.92
     zf-rbx1 48 rkvCPlc 54
                + +CP+c
  EFC38797.1 56 ECHCPIC 62
                5679999 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.008
     zf-rbx1  31 eCgHaFHlhCiskWlkt...rkvCPlc 54 
                 +C+H  H +C+++  +    +++CP+c
  EFC38797.1  76 ACKHFIHDNCLDQLTEIhgkNTKCPIC 102
                 7************9988888999**** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1091  (0.0608511); expected 358.6 (0.02)
Passed bias filter:                      636  (0.0354733); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 1071.76
//
Query:       EFC38798.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       490  (0.02733); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 2113.97
//
Query:       EFC38799.1  [L=268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      1e-41  143.4   4.0    1.3e-41  143.1   4.0    1.1  1  Peptidase_C1   Papain family cysteine protease
     0.0016   18.3   0.0     0.0034   17.3   0.0    1.5  1  Propeptide_C1  Peptidase family C1 propeptide


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.1   4.0   1.5e-45   1.3e-41       3     172 ..      91     267 ..      89     268 .] 0.84

  Alignments for each domain:
  == domain 1  score: 143.1 bits;  conditional E-value: 1.5e-45
                   SCEETTTTTTG.SG---B-TSSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS--SSSCS. CS
  Peptidase_C1   3 esvDwrekgga.vtpvkdqgsCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdypYkakeg. 96 
                   +++D+rek    ++++++q++CGsCWafsa +a++drl+i+t+ + ++ lS q +v+C+  ++ gC+GG+ +na++++ ++gi ++++ pY++ +g 
    EFC38799.1  91 SHFDAREKWEDcIHEIRNQEECGSCWAFSASEAFSDRLCIATNgSVNIVLSPQYMVSCDA-TDYGCDGGYLNNAWNFLANTGIPSDECVPYQSGSGh 186
                   78*****87778*******************************999*************8.89*****************************66666 PP

                   .SS-CGCGGGSE.EBEESEEEEEESS.....BHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEE CS
  Peptidase_C1  97 .gkCkkkkkkek.vakikgygkvken.....seealkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivG 172
                    ++C+k +kk +    ik y+  k++     s e+++k +++ng ++  +++++ df +YksGvy++ + s  +  ha++++G
    EFC38799.1 187 vPSCSKLNKKCQdGSDIKLYKVSKKSianldSIEDIQKDIQENGSIQSGFSVYK-DFFSYKSGVYHHVTGS-LAGGHAIKVIG 267
                   6666654222222344444444333344455789********************.6***********7544.588******99 PP

>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.7e-07    0.0034       4      37 ..      34      70 ..      32      71 .. 0.95

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.7e-07
                   HHHHHHHHC.T-SEEE---..-SSBSHHHHHCCS-B- CS
  Propeptide_C1  4 efIdyiNsk.nttWkAgrN..FdnttlsyikgLlGvl 37
                   ++I++iNs     WkA ++  F++ tl + ++ lG+ 
     EFC38799.1 34 SLIQKINSDsSIRWKATTYkkFEGMTLREARKYLGTV 70
                   68*******999***********99**********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       782  (0.0436165); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1551.86
//
Query:       EFC38800.1  [L=883]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-06   27.2   0.8    1.4e-05   25.3   0.8    2.1  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.3   0.8     8e-10   1.4e-05       3      88 ..     717     798 ..     715     813 .. 0.89

  Alignments for each domain:
  == domain 1  score: 25.3 bits;  conditional E-value: 8e-10
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTT CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrk 88 
                 ++ ++ ++ r++F++++e+efs+en  ++++ e+++++   +   ++  +I   yla+ ++ e+n+++ ++ + ++ le+   + +
  EFC38800.1 717 QKYMNVESFREMFKSYCENEFSSENYLLYEELEKLQQK--GKVYEDDLVRINTLYLANRAQYEVNLPSVTKRKFRELLED--FDIT 798
                 566777889***************************99..7778888**************************9999988..5555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (883 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1217  (0.0678789); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.33s 00:00:01.13 Elapsed: 00:00:00.55
# Mc/sec: 4857.65
//
Query:       EFC38801.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-55  187.1   0.0    8.6e-38  130.3   0.0    2.0  2  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  130.3   0.0   4.8e-42   8.6e-38       5     331 ..      46     394 ..      43     395 .. 0.85
   2 !   55.2   0.1   2.7e-19   4.9e-15     372     447 ..     397     474 ..     394     492 .. 0.82

  Alignments for each domain:
  == domain 1  score: 130.3 bits;  conditional E-value: 4.8e-42
                 SEHHCCHCHHHHTTTCCHHHHHHHHHHHH.-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGH..HHHHHHHH CS
        p450   5 tplplvgnllqlgrkeelhevlrklqkky.gpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfang..ekwkklRr 100
                 +++p++   l ++ ++ + + l+k +      ++rl +  +++vv+s+ ++ ke+l+ kg  f + ++   + +   +f ++ +   +g  + wk++++
  EFC38801.1  46 KNIPIISPYLSFDGHKRMEQ-LVKTHGDPkTGLVRLSMFDRNMVVVSDRDMLKELLVVKGGIFIKSWKLYEVFN---AFGKNILSILDGtsDSWKNHHK 140
                 57888888888886555555.555554444569***************************99999988655555...88888888898888******** PP

                 HHHHHHTSHSTTTHHHHHHHHHHHHHHHHHCCCCHCS.........EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHHHHHCHH.. CS
        p450 101 fltptltsfgklsleelveeeaedlveklrkkagess.........elditellskaaldvigsilFgarfdlledeklselvkaveelssllskss.. 188
                 +   ++ s+ +l+++++v + + dl+++ + + +  +          +d+  ++s+++ldv+g+ +Fg  f+ + de ++e   + + l +++ + +  
  EFC38801.1 141 VASGAFASK-NLEYMSRVASKSLDLCKESKWDGEMEKalkegkegiIIDTNADFSDITLDVLGKAAFGLDFS-IFDETNPEGRIFRKSLEKMFTTGVil 237
                 *********.99***************87766666666677779999*************************.88888777777777777766554411 PP

                 HHCCCCCHHHTCCSCHHHH..HHHHHHHHHHHHHHHHHHHHHHCHCHC...........SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHH CS
        p450 189 vqllllfpllkylptkllr..klkeavkklkdlldklieerretldsa...........kksrrdfldalllakkekkgesklsdeelaatvlellfaG 274
                 ++++ l p+l++ + + ++   l++avk+++d ld++i er ++++ +            ++r+d+l++l++a   +kg   ls +el+  +  + +aG
  EFC38801.1 238 KRFVGLNPVLSWAFPWACKytGLDKAVKVVSDKLDAIIAERTREVELRgmedgntsetgVEERKDLLSVLVEANFIQKGI--LSGDELKSDAYIFSLAG 334
                 344555555555555554422678999********************************779***********9888887..***************** PP

                 HHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCCTTT...T-HHHHCCT-HHHHHHHHHH CS
        p450 275 vdTtsstlswaLyeLaknPevqeklreEidevlgdkr...eptyddlqklpyldavikEt 331
                 ++Tts+tl+w+ yeL ++P++q+k+reEid +lg+      p +dd   + y++avi Et
  EFC38801.1 335 HETTSTTLQWVCYELSTKPDIQNKIREEIDLHLGKGVnarAPNFDDYPIMNYVNAVIMET 394
                 *********************************6644467*******************8 PP

  == domain 2  score: 55.2 bits;  conditional E-value: 2.7e-19
                 T-TTTSSSTTS--GGGGB-TTS..CTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEE CS
        p450 372 rdpevfpnPeeFdpeRFldekg..nskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppil 447
                 r++  +++P eF peR+  + +     +++f ++PF++G R CiG ++A+ e + +l++lLq +e+ l+++++ p+ +
  EFC38801.1 397 RSDRNWDKPLEFIPERYPMNAEeqLRIQHDFTWIPFSMGNRKCIGFKFAQIEAFTILVRLLQFYELGLDNDESNPKDQ 474
                 67788************87766675569***************************************98766665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       609  (0.0339673); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2945.31
//
Query:       EFC38802.1  [L=264]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (264 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3544  (0.197669); expected 358.6 (0.02)
Passed bias filter:                     1118  (0.0623571); expected 358.6 (0.02)
Passed Vit filter:                       143  (0.0079759); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 1609.75
//
Query:       EFC38803.1  [L=186]
Description: histone H3 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-40  139.0   4.2    1.1e-40  139.0   4.2    2.0  2  Histone        Core histone H2A/H2B/H3/H4
     0.0038   17.3   0.1      0.008   16.3   0.1    1.5  1  CENP-T_C       Centromere kinetochore component CENP-T histon
  ------ inclusion threshold ------
      0.022   15.0   0.1      0.053   13.8   0.1    1.7  1  CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) a
      0.028   13.1   9.6      0.029   13.0   9.6    1.1  1  Hamartin       Hamartin protein
      0.041   13.9   0.2      0.069   13.2   0.2    1.3  1  TFIID-31kDa    Transcription initiation factor IID, 31kD subu
        0.1   13.0   0.1       0.18   12.2   0.1    1.3  1  CENP-S         CENP-S protein
       0.33    9.8   8.9       0.34    9.7   8.9    1.1  1  Nucleo_P87     Nucleopolyhedrovirus capsid protein P87
        1.8    7.2   6.2        1.7    7.3   6.2    1.0  1  Ndc1_Nup       Nucleoporin protein Ndc1-Nup
        2.3    7.6   9.1        2.5    7.4   9.1    1.3  1  DUF908         Domain of Unknown Function (DUF908)


Domain annotation for each model (and alignments):
>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   6.5      0.33   6.7e+02       7      44 ..      21      60 ..       2      62 .. 0.65
   2 !  139.0   4.2   5.5e-44   1.1e-40       3     130 ..      45     175 ..      43     176 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.33
                EEEXXXXEEXXXXXXXXXXHT..TS-SSSSB--TTT-XTT CS
     Histone  7 karkesektapekkvsakker..kasskskkkkkrryrpg 44
                +++ ++++t+p+k++s+ +++  ++ s++ ++k++r  p+
  EFC38803.1 21 NTSTKTPSTTPSKTLSKTSTKtpSKTSTKTPSKTPRKTPR 60
                3344566666777777776666656666666666555554 PP

  == domain 2  score: 139.0 bits;  conditional E-value: 5.5e-44
                 EESXEEEXXXXEEXXXXXXXXXXHT...TS-SSSSB--TTT-XTTHHHHHHHHHHHHXXSXXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHHHH CS
     Histone   3 rekekarkesektapekkvsakker...kasskskkkkkrryrpgtvalkeirkyqkstdlliqklpfaRvvreivksekedlrisaeavlalqealEa 98 
                 ++++k++ ++++++p+k++++ +++   k++ +  +kk++ryrpgtval+eirkyqkst+lli k pf R+vre+ ++ k+d r++a ++lalqea+Ea
  EFC38803.1  45 KTSTKTPSKTPRKTPRKTPKKTPAKksaKKPFTGGIKKPHRYRPGTVALREIRKYQKSTELLIKKKPFCRLVREVAQDYKSDVRFQANSLLALQEAAEA 143
                 5666677777777777777777766667999999***************************************************************** PP

                 HHHHHHHHHHHHHHHTTXSEEXHHHHHHHHHH CS
     Histone  99 llvelfeeAnllakhaKRvTitpkDiqlArrl 130
                 +++++fe++nl+a+h+KRvTi  kD+qlA+r 
  EFC38803.1 144 FIIDIFEDTNLCAIHSKRVTILLKDMQLALRV 175
                 ******************************96 PP

>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1     4e-06     0.008      15      76 ..     114     175 ..     103     179 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4e-06
    CENP-T_C  15 klakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilLmkr 76 
                 +l++++a+   s  + ++++l al++a + f+  + eD +  a H++R ti  +D+ l ++ 
  EFC38803.1 114 RLVREVAQDYKSDVRFQANSLLALQEAAEAFIIDIFEDTNLCAIHSKRVTILLKDMQLALRV 175
                 66777777777899******************************************998886 PP

>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   2.7e-05     0.053      17      65 .]     125     173 ..     111     173 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.7e-05
                    TXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF  17 darkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65 
                    ++ ++   +   ++e++e fi ++ + ++  + ++kr ti  ++++lA+
     EFC38803.1 125 SDVRFQANSLLALQEAAEAFIIDIFEDTNLCAIHSKRVTILLKDMQLAL 173
                    5556667777789**********************************97 PP

>> Hamartin  Hamartin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   9.6   1.5e-05     0.029     354     458 ..       4     103 ..       1     155 [. 0.57

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.5e-05
    Hamartin 354 lsssasllsskvsstpeaagkatpetTPakssrklppslsesavvvalpassrksspprkdeksesskpdlskqeevenekeleeslk.skssvtlseL 451
                  sss+ + s++ s  p+++  +tp+tTP+k+++k++++ + s+++    +++ +s+ prk  +++ +k++ +k+++ + + +++++ + +  +v l+e+
  EFC38803.1   4 TSSSTAETSTETSEVPNNTSTKTPSTTPSKTLSKTSTK-TPSKTS----TKT-PSKTPRKTPRKTPKKTPAKKSAKKPFTGGIKKPHRyRPGTVALREI 96 
                 56666666677777777777777778887777643222.222222....222.3333444445555555555555555555555555545566666666 PP

    Hamartin 452 sdvikel 458
                 ++++k++
  EFC38803.1  97 RKYQKST 103
                 6666655 PP

>> TFIID-31kDa  Transcription initiation factor IID, 31kD subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   3.5e-05     0.069      23      70 ..     129     176 ..     114     181 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.5e-05
  TFIID-31kDa  23 yeerVvlqLldfayrytssvLedAkvlaehakkkevslddvrlAiqsr 70 
                  ++ + +l L + a  ++++++ed +++a h+k+ ++ l+d++lA+  +
   EFC38803.1 129 FQANSLLALQEAAEAFIIDIFEDTNLCAIHSKRVTILLKDMQLALRVK 176
                  56667889999*********************************8765 PP

>> CENP-S  CENP-S protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   8.8e-05      0.18      20      71 ..     123     174 ..     109     177 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 8.8e-05
      CENP-S  20 aekeveatkqfiaaltelvykqlenlakDLeaFakHAkRstittdDvlLlaR 71 
                  +++v++  + + al e   + + ++ +D ++ a H kR ti  +D+ L +R
  EFC38803.1 123 YKSDVRFQANSLLALQEAAEAFIIDIFEDTNLCAIHSKRVTILLKDMQLALR 174
                 366778888889999999999****************************998 PP

>> Nucleo_P87  Nucleopolyhedrovirus capsid protein P87
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   8.9   0.00017      0.34     296     359 ..       5      72 ..       1     128 [. 0.64

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00017
  Nucleo_P87 296 aeqslqspaqtpa..perslqsPeqtparrkstkmtee....slqsPaqtpawqtpattptretssdtea 359
                 + ++ ++ ++t +  +++s ++P++tp ++ s + t++    s+++P +tp  +tp++tp++++  ++ a
  EFC38803.1   5 SSSTAETSTETSEvpNNTSTKTPSTTPSKTLSKTSTKTpsktSTKTPSKTPR-KTPRKTPKKTPA-KKSA 72 
                 334444455555577899*********9987777777632345555555555.555555554443.2222 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   6.2   0.00084       1.7     364     443 ..      11      77 ..       1     167 [. 0.45

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00084
    Ndc1_Nup 364 kapknkasapvkelprlsksplkkkddeifgnsltaeaspkssssskegvekalsslakspgqspsptarlsprarklle 443
                 + +++++ ++++++++ s++p+k+     + +++t+++s+ s+++++++++k+  ++ k+     +p++   ++a+k ++
  EFC38803.1  11 TSTETSEVPNNTSTKTPSTTPSKT-----LSKTSTKTPSKTSTKTPSKTPRKTPRKTPKK-----TPAK---KSAKKPFT 77 
                 111222222222222222223322.....1112222222222222222222221111111.....1111...22222222 PP

>> DUF908  Domain of Unknown Function (DUF908)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   9.1    0.0013       2.5     154     217 ..      10      67 ..       1     145 [. 0.53

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0013
      DUF908 154 kaesksskeeasesli.........ssspstPtplrrssklgktssspsspaktstpskaaksqeglktfeip 217
                 ++++++s+ ++++s++          s++st tp+++s+k                 sk++ ++   +  + p
  EFC38803.1  10 ETSTETSEVPNNTSTKtpsttpsktLSKTSTKTPSKTSTKTP---------------SKTPRKTPRKTPKKTP 67 
                 333333333322222111122222222233333333222222...............2222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1295  (0.0722293); expected 358.6 (0.02)
Passed bias filter:                      576  (0.0321267); expected 358.6 (0.02)
Passed Vit filter:                       113  (0.00630264); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 1140.25
//
Query:       EFC38804.1  [L=379]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (379 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2413.39
//
Query:       EFC38805.1  [L=469]
Description: RGS domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-08   34.8   4.1    4.4e-08   33.4   4.1    1.8  1  RGS            Regulator of G protein signaling domain
     0.0027   18.0   0.3       0.39   11.1   0.1    3.0  2  Thioredoxin_8  Thioredoxin-like


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.4   4.1   4.9e-12   4.4e-08       2     118 .]     315     463 ..     314     463 .. 0.97

  Alignments for each domain:
  == domain 1  score: 33.4 bits;  conditional E-value: 4.9e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS................................SHHHHHHHHHHHHHHHHTSTTSTTSSTS CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka................................keqeelkkkakeIyneylapsspkelni 68 
                 ++++le+ + r +F+  l + +s e + F+++v+ +k                                  ++  e  +ka+ I++++l++++  ++n 
  EFC38805.1 315 MSNVLENATMRTYFKAHLSNMYSLELVLFLEQVNIYKFLvkslksqstcqnllsseeqilqdislpasemvTTIPEYETKARYIVETFLNDEAMFHINT 413
                 7899*********************************99999********************************************************* PP

                 -HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS  69 dkklreelekrlekeqpsrklfeeaqeevfellekdsypkFlkselylrl 118
                 ++kl++++++ +e++   ++lf+e++  v + +    +  F ++ l++++
  EFC38805.1 414 SRKLTDRMKTLIEEKGFIEELFDEIEMDVKTSMLVYLFASFRQTTLFTEM 463
                 ***********************************************875 PP

>> Thioredoxin_8  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.1   4.4e-05      0.39      12      70 ..      69     123 ..      58     162 .. 0.77
   2 !    3.8   0.0    0.0082        73       8      35 ..     225     250 ..     218     261 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 4.4e-05
                    SSHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-S.S-HHHHHHHGGGS-TTSEE.EE-TT- CS
  Thioredoxin_8  12 wcppckaftpklkelyeklkkkkkveivyvsld.kkeeefekylkknkkpwlsvpfddkk 70 
                     cp+c++ + +l+e+  +l     ++i+ v ++ ++e +f k+++++  +  ++  +   
     EFC38805.1  69 GCPMCQKLIDNLDEYLPSLL---MLNIIPVICHqEDETKFGKHISHT--KLFHCKISTQA 123
                    6******************9...9********9569***********..55555444433 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.0082
                    E--SSSHHHHHHHHHHHHHHHHHHHTTS CS
  Thioredoxin_8   8 fgaswcppckaftpklkelyeklkkkkk 35 
                    + +s+ ++ ++f+p+l++ly +lkk   
     EFC38805.1 225 YKKSEIEEVEQFLPNLIKLYPDLKK--V 250
                    5667788899*************94..3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (469 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       969  (0.0540465); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.25s 00:00:00.83 Elapsed: 00:00:00.42
# Mc/sec: 3333.68
//
Query:       EFC38806.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1965  (0.109599); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2160.48
//
Query:       EFC38807.1  [L=269]
Description: hypothetical protein NAEGRDRAFT_81465 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      7e-11   42.0   2.0    2.2e-10   40.4   2.0    1.7  1  Pkinase      Protein kinase domain
     0.0086   15.4   1.6      0.059   12.7   1.6    2.2  1  Pkinase_Tyr  Protein tyrosine kinase
  ------ inclusion threshold ------
       0.12   13.1   0.2        0.4   11.5   0.1    1.8  2  DUF5327      Family of unknown function (DUF5327)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.4   2.0   3.6e-14   2.2e-10      93     260 ..      50     250 ..      25     254 .. 0.80

  Alignments for each domain:
  == domain 1  score: 40.4 bits;  conditional E-value: 3.6e-14
                 SS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE..TTTE..EEE-SGTTSEESSSSCS............................BCTTTS CS
     Pkinase  93 gslseeeakkiakqilegleylHskgiiHrDlKpeNiLid..ekge..lKitDFGlakelesssk............................ltsfvg 159
                 + ls++ +  i+ ++++ l+ lH++++++r l  eNiLi+  ++g+  + +  ++ + el  +++                             ++  +
  EFC38807.1  50 QPLSPNFLLVIVFKTVRLLDLLHKHHLVYRNLTLENILIEklQDGNlnVHLNNLDKSIELLIDQQvnltstisfqgdehavsynaplhqyfdfNRNAQI 148
                 456666777788899999**********************444444778888888887776666677999999999999*************9999*** PP

                 CGGGS-HHHH....TTSCB.SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCST CS
     Pkinase 160 tseYlAPEvl....keney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRl 253
                 t+ Y +PE++     e+++   k+ +Wsl++ ++ +l++k +     + e++ ++ld+l+  +++ ++   + +e ++i   +k++ +++l+ +  +R+
  EFC38807.1 149 THGYEPPEIIhsttCEKPFiCLKSEIWSLAICILRVLFRKSIII---HPENYVEQLDELF-GREVDEDLVATQDESKTIMTCLKEMTRNMLCPNVYERW 243
                 **********6655335555889********************9...4455666666632.344555666778888999999***************** PP

                 THHHHHT CS
     Pkinase 254 taeellq 260
                 +++++++
  EFC38807.1 244 SCADVIE 250
                 *999876 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   1.6   9.8e-06     0.059      83     195 ..       8     181 ..       1     235 [. 0.67

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 9.8e-06
                  -TTEBHHHHHHHT...........................CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE............... CS
  Pkinase_Tyr  83 vkgGdLlkfLrkk...........................ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse............... 138
                  v++G++ +f  ++                            +++l+ + ll ++++  + ++ L++++lv r+l+  N+L+++               
   EFC38807.1   8 VREGKVASFSASSvkdvsdhhlavkslaqllteeeeqhdaMNQPLSPNFLLVIVFKTVRLLDLLHKHHLVYRNLTLENILIEKlqdgnlnvhlnnldk 105
                  55555555555555555555555555555555557777778899999999********************************9777777666666666 PP

                  ..........TTEEEE-STT....THEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.....EEHHHHHHHHHHHH CS
  Pkinase_Tyr 139 ..........nkvvkisDfG....LardiekddeyvkkeeaklpvkWmapEslkekk.....ftsksDvWsfGvll 195
                            n +  is  G    ++ +   +++   +++a++   + +pE++++++     +  ks +Ws ++++
   EFC38807.1 106 siellidqqvNLTSTISFQGdehaVSYNAPLHQYFDFNRNAQITHGYEPPEIIHSTTcekpfICLKSEIWSLAICI 181
                  6666665555444444433311002222233333455666666666666666666665555555566666666665 PP

>> DUF5327  Family of unknown function (DUF5327)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   6.7e-05       0.4       7      51 ..       2      47 ..       1      56 [. 0.79
   2 ?   -1.6   0.0      0.77   4.6e+03      25      48 ..      93     119 ..      86     148 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 6.7e-05
     DUF5327  7 tvlekmeeelekak.kaeseakvrehiaaikalceLlleeeaeeka 51
                ++++++ +e + a  +a+s + v +h  a+k+l++Ll eee++++a
  EFC38807.1  2 SIVNQLVREGKVASfSASSVKDVSDHHLAVKSLAQLLTEEEEQHDA 47
                578888888888988999*********************7653332 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.77
     DUF5327  25 eakvrehiaaikalceLlleeea...e 48 
                 + +++ h++++    eLl +++    +
  EFC38807.1  93 DGNLNVHLNNLDKSIELLIDQQVnltS 119
                 556777888888888999887653330 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       509  (0.0283898); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.37s 00:00:00.95 Elapsed: 00:00:00.55
# Mc/sec: 1477.31
//
Query:       EFC38808.1  [L=404]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   11.9   3.4       0.22   11.1   3.4    1.4  1  FAM83     FAM83 A-H
        0.4   10.5   3.4       0.14   12.0   0.5    1.7  2  BTHB      Basic tilted helix bundle domain


Domain annotation for each model (and alignments):
>> FAM83  FAM83 A-H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   3.4   2.4e-05      0.22      28     119 ..     182     274 ..     164     285 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 2.4e-05
       FAM83  28 Geeaf.kevlkeeklrdFL..seeelerilesaekeeyeeeeeeeeeeeeeeessvsltYwPeqsdtevPeldlgWpeeaslkgvtrvtvytqpp 119
                 G ++f ++ l++++++++L  se+e e+i++++  e+ ++e e+++++e++++++ s    P q  ++ P+     ++++   + t v++ t+ +
  EFC38808.1 182 GINQFvTNQLQKKNIVQYLqdSEQEKETIKSNV--ENLKKELERKDADESNTTPTKSRVITPAQTSVKRPTSASKSTNSYNNYNSTLVNTQTNSS 274
                 555552468**********555778899*****..555555555556666666667999***********9987777554444444444444443 PP

>> BTHB  Basic tilted helix bundle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.5   1.6e-05      0.14       8      30 ..     184     206 ..     180     226 .. 0.78
   2 ?   -3.4   0.1         1   9.1e+03      42      61 ..     243     262 ..     239     270 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.6e-05
        BTHB   8 eqLasdalpKkdlikfLqenAae 30 
                 +q+ +++l Kk+++++Lq+  +e
  EFC38808.1 184 NQFVTNQLQKKNIVQYLQDSEQE 206
                 6889**************98664 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1
        BTHB  42 iknVaKtankeqLieaYkkl 61 
                  ++V++  + ++ ++ Y++ 
  EFC38808.1 243 QTSVKRPTSASKSTNSYNNY 262
                 67888888888888888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (404 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2325  (0.129678); expected 358.6 (0.02)
Passed bias filter:                      682  (0.0380389); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 2391.77
//
Query:       EFC38809.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.075   12.9   0.1        0.2   11.5   0.0    1.8  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   1.1e-05       0.2       7      32 ..       5      30 ..       4      31 .. 0.92
   2 ?   -3.7   0.0      0.64   1.1e+04      16      25 ..     200     209 ..     196     210 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1.1e-05
  F-box-like  7 EiLlqIFsyLppsdLlrlalVCrrWr 32
                +i++ I s+Lp++++  l +VC+ W+
  EFC38809.1  5 DIISVIASFLPLQQMMKLERVCKEWK 30
                6888899******************6 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 0.64
  F-box-like  16 LppsdLlrla 25 
                  p+ dL++l+
  EFC38809.1 200 YPQADLVNLS 209
                 4788999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       888  (0.0495287); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 2385.79
//
Query:       EFC38810.1  [L=375]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0089   15.9   0.0      0.031   14.2   0.1    1.9  2  PB1       PB1 domain


Domain annotation for each model (and alignments):
>> PB1  PB1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0      0.46   8.2e+03      14      38 ..      36      63 ..      28      79 .. 0.66
   2 !   14.2   0.1   1.7e-06     0.031      24      82 ..     119     176 ..     110     178 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.46
                E...EEEEGSSS-HHHHHHHHHHHHTST CS
         PB1 14 r...elsvssnisfeeLrakvekrfkls 38
                r   +++ + ++ +e ++++ +  f + 
  EFC38810.1 36 RmipIIFNNQEVGYEAFVSEAGASFDQG 63
                2466677777788888888777777765 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 1.7e-06
                 HHHHHHHHHHHHTSTCCSEEEEEEETTSSEEEESSHHHHHHHHHHHHHTSSCCEEEEEE CS
         PB1  24 feeLrakvekrfklsdedvklkYpdedgdlVtitsDeDLeealeearslksktlrlhvq 82 
                 f+ L+ +++k f+++ e+vk++       +V i +D+D ++al++     + +++++++
  EFC38810.1 119 FDGLMMRIGKLFPQE-EQVKISCVIGKSRKVAIQNDDDWQHALQQLLLNDETMIKIFIK 176
                 99************8.*****************************85435558888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2324  (0.129622); expected 358.6 (0.02)
Passed bias filter:                      626  (0.0349155); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2242.03
//
Query:       EFC38811.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1089  (0.0607396); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1059.51
//
Query:       EFC38812.1  [L=132]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1172  (0.065369); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 783.80
//
Query:       EFC38813.1  [L=216]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.2e-13   49.2   0.0    5.4e-13   48.9   0.0    1.1  1  SBP_bac_3        Bacterial extracellular solute-binding prote
  ------ inclusion threshold ------
      0.021   14.2   0.0      0.033   13.6   0.0    1.2  1  Put_Phosphatase  Putative Phosphatase
      0.044   14.0   0.5        5.6    7.2   0.0    2.3  2  zf-RING_7        C4-type zinc ribbon domain
      0.098   12.9   0.0       0.17   12.1   0.0    1.4  1  DapH_N           Tetrahydrodipicolinate succinyltransferase N


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.9   0.0   1.2e-16   5.4e-13      47     174 ..      36     162 ..      26     184 .. 0.86

  Alignments for each domain:
  == domain 1  score: 48.9 bits;  conditional E-value: 1.2e-16
                 GGGHHHHHHTTSSSEEESSEB--HHHHTTEEEESESEEEEEEEEEEETTSHGTCCHSSCGCGTTS..EEEEETTSHHHHHHHHHHHCTSEEEEESSHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3  47 wdelipalksgkvDiaiaaititpeReekvdFsqpyfsagqvllvrkkdaskissiksladLkgk..kvgvqagstaeellkeelkkgaeivefdtlee 143
                 + +l +a++s  + +aia++ + + R+ +vdF  py ++ +++l  + d  + + +++++dL+     v++   +t+ e++k++++ +a+i +   +  
  EFC38813.1  36 FPTLKNAVQSSICHVAIASTNYEESRASEVDFQCPYGTSYTGILRSERD--NNTILTTPSDLNKEgiIVAAPYLTTSYEYAKSNFP-KATILSNFGYKT 131
                 66778999************************************99744..346778899**6652256666669********998.89999999**** PP

                 HHHHHHTTSSSEEEEEHHHHHHHHHHCCGCC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 144 alqaLkngrvdavvadspvlaylvkknpdkk 174
                 a++++ +++v avv+d + + ++++ n+++ 
  EFC38813.1 132 AYKMVFTKEVHAVVGDYIEMSEWLEANKGNC 162
                 *************************999876 PP

>> Put_Phosphatase  Putative Phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   7.4e-06     0.033     118     170 ..      87     139 ..      81     151 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 7.4e-06
  Put_Phosphatase 118 eiftNPaavdasGeltvlpyhehsCklcpsNlCKgkvleelvaeqaregveye 170
                       i+t P+ ++++G +  +py + s + + sN  K ++l+++  ++a + v  +
       EFC38813.1  87 TILTTPSDLNKEGIIVAAPYLTTSYEYAKSNFPKATILSNFGYKTAYKMVFTK 139
                      699**************************************999877665444 PP

>> zf-RING_7  C4-type zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0    0.0012       5.6       4      28 ..      47      71 ..      45      71 .. 0.88
   2 ?    4.9   0.1     0.007        31       2      15 ..     162     175 ..     161     176 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0012
                TT--B--CCHHHHHCCSTB-.EE-TT CS
   zf-RING_7  4 GChmelppqvlselragdev.vtCpe 28
                 Ch+++ +  + e+ra + v ++Cp+
  EFC38813.1 47 ICHVAIASTNYEESRASE-VdFQCPY 71
                6****************5.55***97 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.007
                 ETTT--B--CCHHH CS
   zf-RING_7   2 CgGChmelppqvls 15 
                 C+ C+m++  ++++
  EFC38813.1 162 CSRCYMKITDSSQN 175
                 ********998876 PP

>> DapH_N  Tetrahydrodipicolinate succinyltransferase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   3.8e-05      0.17      33      72 ..     128     167 ..     101     175 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.8e-05
                 ---TTSEEEE-SSEEEEEEEHHHHHHHHHHTTTTEEEEEE CS
      DapH_N  33 efpeevkvfgsedsgvvfGdwkeieevleenkdkiedyev 72 
                  +++ +k++ +++++ v+Gd+ e++e le+nk + + +++
  EFC38813.1 128 GYKTAYKMVFTKEVHAVVGDYIEMSEWLEANKGNCSRCYM 167
                 4457899*************************99888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (216 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       456  (0.0254337); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 1291.66
//
Query:       EFC38814.1  [L=182]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       692  (0.0385967); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.48
# Mc/sec: 1135.72
//
Query:       EFC38815.1  [L=586]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-06   28.7   7.0    3.8e-06   27.2   6.5    2.1  1  RGS       Regulator of G protein signaling domain
     0.0042   17.0   1.7       0.02   14.8   1.7    2.2  1  DUF3137   Protein of unknown function (DUF3137)
  ------ inclusion threshold ------
      0.062   13.8   0.1       0.22   12.0   0.1    2.0  2  DUF4231   Protein of unknown function (DUF4231)
      0.084   12.8   0.8       0.85    9.6   0.2    2.6  2  COX_ARM   COX Aromatic Rich Motif


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   6.5   8.4e-10   3.8e-06       2     109 ..     415     549 ..     414     558 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 8.4e-10
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS................. CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke................. 83 
                 les ledq+ r++Fr++ ++efs en+  +++ e++kk+  ++ + ++ k++ +++l +ss +e+n +++++++ ++ l                    
  EFC38815.1 415 LESFLEDQQFREMFRTYSKNEFSLENIIMYEELEKLKKN--NKVTPQELKSLQEKFLLSSSVHEVNYPSAVKKNFQELLDSYkdedvssndsdsttqtk 511
                 7899**********************************9..88999****************************9998877666666666666666666 PP

                 ............STTTTTTHHHHHHHHHHHHHHHHHHH CS
         RGS  84 ............qpsrklfeeaqeevfellekdsypkF 109
                             ++   ++e++ e v+  l k+++  F
  EFC38815.1 512 ssnslkqstglpKKGTVMLEKMLELVMPELLKNMFDTF 549
                 66666666666555555555555555555555555555 PP

>> DUF3137  Protein of unknown function (DUF3137)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   1.7   4.5e-06      0.02      25      83 ..     399     459 ..     373     473 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.5e-06
     DUF3137  25 k..kakeskkkkekklekvkledpeFekkFeVysndqvearyiLtpalmerllelrekfkg 83 
                 k   +k ++++ +  + +  led++F+++F +ys+++     i+  + +e+l++ ++ + +
  EFC38815.1 399 KfrRLKSKYRNAQVTTLESFLEDQQFREMFRTYSKNEFSLENIIMYEELEKLKKNNKVTPQ 459
                 255445566666777777889*******************************998776655 PP

>> DUF4231  Protein of unknown function (DUF4231)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1     5e-05      0.22      20      79 ..     344     413 ..     334     435 .. 0.86
   2 ?   -3.9   0.0         4   1.8e+04      75      92 ..     453     470 ..     451     473 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 5e-05
     DUF4231  20 lrlitivlgallpilvs..........sklgagvsvlkiltallsalvailaaleeffrykerWrryRst 79 
                 l ++++ +g ++pi+v             +   v ++ ++ a+++ +v+i   + +f+r k ++r++  t
  EFC38815.1 344 LFIMILMMGSVIPIIVGsvedgtpyfiVRKVFTVVFFVMFYAIIGGTVTIAHWINKFRRLKSKYRNAQVT 413
                 56888999*******999*********66888999******************************98766 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 4
     DUF4231  75 ryRstaEsLktekwlfla 92 
                 +++ t + Lk+ + +fl+
  EFC38815.1 453 NNKVTPQELKSLQEKFLL 470
                 789999999999999986 PP

>> COX_ARM  COX Aromatic Rich Motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.2   0.00019      0.85      10      29 ..     298     317 ..     296     321 .. 0.88
   2 ?    0.2   0.0      0.17   7.5e+02      12      25 ..     444     457 ..     442     457 .. 0.94

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00019
                 HHHHHHCSS-SS--SEEES- CS
     COX_ARM  10 deYleLakPSennPVeyFss 29 
                 ++Yl++ kPS+n+  eyFs 
  EFC38815.1 298 NTYLSYSKPSSNYDMEYFSM 317
                 68****************95 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.17
                 HHHHCSS-SS--SE CS
     COX_ARM  12 YleLakPSennPVe 25 
                 Y+eL+k + nn+V+
  EFC38815.1 444 YEELEKLKKNNKVT 457
                 9***********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (586 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1215  (0.0677673); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.43
# Mc/sec: 4131.45
//
Query:       EFC38816.1  [L=678]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (678 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       869  (0.048469); expected 358.6 (0.02)
Passed bias filter:                      574  (0.0320152); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 3975.04
//
Query:       EFC38817.1  [L=206]
Description: hypothetical protein NAEGRDRAFT_81470 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00036   20.8   1.2        0.7   10.2   0.0    2.1  2  DUF5013         Domain of unknown function (DUF5013)
  ------ inclusion threshold ------
      0.046   14.2   0.2      0.085   13.4   0.2    1.4  1  Peptidase_S8_N  N-terminal of Subtilase family


Domain annotation for each model (and alignments):
>> DUF5013  Domain of unknown function (DUF5013)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.0   7.8e-05       0.7      71     124 ..      11      66 ..       5      83 .. 0.76
   2 !   10.0   0.3   8.7e-05      0.78      62     110 ..     122     167 ..      73     187 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 7.8e-05
     DUF5013  71 LpaGkYelsvtvaeengqnsngtaylvvakgst..LPdlenletalaylsylkvak 124
                 + a +Y+l v+ ++ + + +++ ++++v k+ +  +Pd+  ++ a+ +   +kv+k
  EFC38817.1  11 INAQEYQLAVSENKDQMETKDDSYFIIVDKEGKivIPDTIGIKLADMTDLEIKVQK 66 
                 66789********99999998888888888777789*****987776654444444 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 8.7e-05
     DUF5013  62 NgkiYQtvtLpaGkYelsvtvaeengqnsngtaylvv.akgstLPdlenl 110
                  +ki ++++L+a kYel +   ++++ n+   +y  v  +g++  +++n+
  EFC38817.1 122 THKIRKQTQLQAQKYELGFFSLKFENMNEA--YYKTVnIEGEK--EIDNI 167
                 58*****************99999988887..44333033332..34444 PP

>> Peptidase_S8_N  N-terminal of Subtilase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.2   9.4e-06     0.085      57     109 ..      65     116 ..      57     140 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 9.4e-06
  Peptidase_S8_N  57 ertrkaGLhlWYdvkfdesvdlseaaeelkslagvevveyvrkikraaeeeat 109
                     ++++kaG+++W ++++ e+vd s+ ++ lk++++  +++ + +i  ++ ++++
      EFC38817.1  65 QKKKKAGIEKWKKIHIAEKVDASDQESLLKTIENQLKINDILDISLSS-DTHK 116
                     6899****************************9999999998888883.2222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (206 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1499  (0.0836076); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 1367.12
//
Query:       EFC38818.1  [L=406]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.3e-10   38.0   5.2     0.0012   18.8   0.1    5.3  6  NHL       NHL repeat
  ------ inclusion threshold ------
      0.095   12.1   0.6       0.15   11.4   0.6    1.2  1  ELH       Egg-laying hormone precursor
        0.1   11.4   0.1       0.15   10.8   0.1    1.2  1  RHSP      Retrotransposon hot spot protein


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1     0.035   2.1e+02       3      24 ..      65      87 ..      63      88 .. 0.76
   2 ?   -0.8   0.0      0.33     2e+03       3       9 ..     107     113 ..     107     117 .. 0.81
   3 !   11.6   0.3   3.7e-05      0.22      11      27 ..     232     248 ..     230     249 .. 0.88
   4 ?   -3.1   0.0       1.8   1.1e+04       1      10 [.     323     332 ..     323     333 .. 0.77
   5 ?    2.7   0.0     0.025   1.5e+02      15      27 ..     341     353 ..     340     354 .. 0.88
   6 !   18.8   0.1     2e-07    0.0012       1      27 [.     375     402 ..     375     403 .. 0.95

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.035
                SEEEEEEE.TTTEEEEEECCCTE CS
         NHL  3 yPhGvavd.snGdiyVaDsenhr 24
                +P ++++    + i+V+D++n r
  EFC38818.1 65 SPYDIVIApRLNCIVVSDFGNER 87
                66677777778889****99966 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.33
                 SEEEEEE CS
         NHL   3 yPhGvav 9  
                 +P+G++v
  EFC38818.1 107 MPTGLCV 113
                 69****9 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 3.7e-05
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                  ++ ++VaD++nh +++
  EFC38818.1 232 RDNVVFVADNYNHAIKI 248
                 5899**********986 PP

  == domain 4  score: -3.1 bits;  conditional E-value: 1.8
                 BSSEEEEEEE CS
         NHL   1 fnyPhGvavd 10 
                 +++P G+++d
  EFC38818.1 323 LYSPFGICID 332
                 567889**97 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.025
                 EEEEECCCTEEEE CS
         NHL  15 iyVaDsenhrvqv 27 
                 ++V+Ds+++++++
  EFC38818.1 341 LIVSDSYHSSLKI 353
                 89*******9987 PP

  == domain 6  score: 18.8 bits;  conditional E-value: 2e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 f +P G++++  + +i+  D++n+r+qv
  EFC38818.1 375 FHHPYGLCYNrRQQEILLVDRNNSRIQV 402
                 77899**********************9 PP

>> ELH  Egg-laying hormone precursor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.6   2.5e-05      0.15      38      91 ..     113     166 ..      90     170 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 2.5e-05
         ELH  38 atkravksssvevvlspedsgsnrprsvlgeafdkssadvdddsddvvsnekrr 91 
                 +++r  +ss    v s+    +     +l  ++++ss d ddd++++  +ek+r
  EFC38818.1 113 VEERGCTSSRLWNVSSTTTTNTSTSPRALDSNDEQSSDDDDDDDNEFNDEEKNR 166
                 789999988888898888755555556788888888889999999999999998 PP

>> RHSP  Retrotransposon hot spot protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   2.5e-05      0.15     181     240 ..     235     301 ..     225     314 .. 0.78

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 2.5e-05
        RHSP 181 rvtfyedeedavkaveelar...enlkGyiiydvgkdldtPaPldpPegw....avivlasPdkksy 240
                  v    ++++a+k+v  +     + +  y+ y +gk+++   P    + +    + +++asPdk++ 
  EFC38818.1 235 VVFVADNYNHAIKIVSTVDGsilQSITRYVSYSLGKEIHVKNPNIVNVECftkfGEVIIASPDKNNI 301
                 3444568999999999887767789999***********99997766654333388********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (406 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       823  (0.0459033); expected 358.6 (0.02)
Passed bias filter:                      604  (0.0336884); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.43
# Mc/sec: 2843.24
//
Query:       EFC38819.1  [L=892]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-28   98.3   2.8    3.9e-28   98.3   2.8    4.3  4  DUF4211   Domain of unknown function (DUF4211)


Domain annotation for each model (and alignments):
>> DUF4211  Domain of unknown function (DUF4211)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   2.2      0.61   1.1e+04      32      32 ..     147     147 ..     103     189 .. 0.53
   2 ?   -2.4   1.1      0.25   4.5e+03      62      62 ..     338     338 ..     272     374 .. 0.54
   3 !   98.3   2.8   2.2e-32   3.9e-28       1     135 [.     457     609 ..     457     620 .. 0.89
   4 ?    1.9   0.1     0.011     2e+02      25      55 ..     661     696 ..     627     734 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 0.61
     DUF4211  32 h 32 
                 +
  EFC38819.1 147 Y 147
                 1 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.25
     DUF4211  62 r 62 
                 +
  EFC38819.1 338 D 338
                 2 PP

  == domain 3  score: 98.3 bits;  conditional E-value: 2.2e-32
     DUF4211   1 dFivededeelgapd.......eeeeedelplef....sskahk..dlkehFkdvvewlvsnaldpdfllafeerkdelylvalkklddevegladslv 86 
                 +Fiv+de+ e +ap+       +++e+d+ ++ef    +s+++   d+k++F ++++++ s+ ld+df+++++ ++++++ +a k+++ ++e ++dsl+
  EFC38819.1 457 QFIVSDEE-EDEAPEynvyrmvDMMENDMDSQEFhsilTSNTRLssDFKSSFAIYIHFITSHLLDEDFIQSLKFKDRTHFANASKMVEGKLETVKDSLI 554
                 69*77765.56777788899999999999*****998743433368*********************8777777888********************** PP

     DUF4211  87 sssaWkpefkkaLearPelditelease......ekkCdAcnrskhpatysvrls 135
                  ssaWk+++k+ L+ +P ++ +e++ ++      +k+C+Ac+r++h+a+y++ ++
  EFC38819.1 555 YSSAWKSRHKNLLQFYPIIKAREISLKDteidnsDKCCQACGRKNHQAEYTLIFK 609
                 ***************************************************9995 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.011
     DUF4211  25 lef...sskahkdlkehFkdvvewlvsnaldpd..f 55 
                 + f   + ++++ l+++F+++   l+++++++    
  EFC38819.1 661 KSFvgsTCYKRSLLYHSFQHYKFHLIQHIINKIdkI 696
                 3446667788999*****************987533 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (892 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2858  (0.159407); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                       182  (0.0101512); expected 17.9 (0.001)
Passed Fwd filter:                        54  (0.00301188); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.73u 0.36s 00:00:02.09 Elapsed: 00:00:00.57
# Mc/sec: 4738.60
//
Query:       EFC38820.1  [L=499]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.6e-16   59.3   0.4    2.5e-15   56.9   0.4    2.2  1  RNA_lig_T4_1  RNA ligase
  ------ inclusion threshold ------
      0.047   13.8   4.6      0.074   13.1   2.0    2.4  2  ApoLp-III     Apolipophorin-III precursor (apoLp-III)
      0.083   13.1   0.0       0.21   11.8   0.0    1.7  1  ORF_2_N       Open reading frame 2 N-terminal domain


Domain annotation for each model (and alignments):
>> RNA_lig_T4_1  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.9   0.4   4.2e-19   2.5e-15      42     220 .]      45     309 ..      27     309 .. 0.79

  Alignments for each domain:
  == domain 1  score: 56.9 bits;  conditional E-value: 4.2e-19
  RNA_lig_T4_1  42 qgpyelteKenGclilis...............alsdgklvvaSkhsl................................................. 74 
                   ++p++l+eK +G+l  ++               +l++++++  S +++                                                 
    EFC38820.1  45 EQPFVLLEKLDGSLCSPIiervvsesdasslnsSLKKNNFASVSAEKIekraydtfrlrmrtklshtnaivmgmeeliydlgdegtrrnakgedikl 141
                   79**************99666666555555555555555555555555************************************************* PP

  RNA_lig_T4_1  75 .......................eaeshaevgerllek.....klekegkteeeLaeelleknlTavfElcddsfeehivaypeekagLyLhglnen 143
                                          e+    ++ e+ le      +l+++ +++ +++ ++++k++T++fE+ ++  e++iv  + +k+ L L++l+++
    EFC38820.1 142 ilndhlknvptfeyktsemtkeeEEYLVFKIDEQALEIdanftQLSEKVQNFIRFCIHWINKGFTPLFEFFSK--EHKIVIDYGDKPFLSLLALRHT 236
                   **************999999887333344445555544444434888888899********************..99999999************99 PP

  RNA_lig_T4_1 144 tp.efstesseevakfakefg......fiktklitlesleevkkfleevaetgswegeeiEGfVvrckskkdffFklKfkepyy 220
                       f  +s  +v+k a+++g      + ++++i+  +  +++++l+++++++      +EG+V+ +++     +++K+k+ +y
    EFC38820.1 237 VDgYFLPYS--QVKKSAQQYGidcvkeCSNEQVIEAAKTGDMDEILKAIRNERG-----VEGYVLVLNN-G---WMFKVKSMWY 309
                   996777777..**********854444444444444444477777777777776.....********88.4...5666666666 PP

>> ApoLp-III  Apolipophorin-III precursor (apoLp-III)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.19   1.1e+03      73      96 ..     171     194 ..     146     199 .. 0.69
   2 ?   13.1   2.0   1.2e-05     0.074      21     102 ..     355     435 ..     349     450 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.19
   ApoLp-III  73 klseenPevkkkaqelqekvQsgv 96 
                 k+ e+  e+  + ++l+ekvQ+ +
  EFC38820.1 171 KIDEQALEIDANFTQLSEKVQNFI 194
                 455555566666667777777644 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 1.2e-05
   ApoLp-III  21 eevvetiKensenlvdqlkqvikslqeelkkksdeleealkevkkkieetadklseenPevkkkaqelqekvQsgvqslvke 102
                 +e++ t+ +  +n+v++++q+ + +q el+k+ ++ +++ +   k+ +++a+++ + +P+ +  a   ++k Q++++sl+ke
  EFC38820.1 355 QEFNDTVINALNNYVSKVQQFKEIIQLELQKEFPN-TPIEEIPMKDYSRVAKQVIKDEPNYVFTALVVNKKDQTSLSSLIKE 435
                 89*****************************8865.45555567889**********************************9 PP

>> ORF_2_N  Open reading frame 2 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   3.5e-05      0.21      65     109 ..     246     290 ..     223     299 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.5e-05
     ORF_2_N  65 sasalAqdhgLslvkqsgeiallkAaagtdLlaLvdaLeqssrvk 109
                 ++++ Aq++g + vk+ ++  +++Aa+  d+ ++++a+++++ v+
  EFC38820.1 246 QVKKSAQQYGIDCVKECSNEQVIEAAKTGDMDEILKAIRNERGVE 290
                 67889************************************9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (499 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1319  (0.073568); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 3068.43
//
Query:       EFC38821.1  [L=1523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.8e-53  179.8   0.0    7.3e-53  178.9   0.0    1.5  1  Guanylate_cyc   Adenylate and Guanylate cyclase catalytic dom
  ------ inclusion threshold ------
      0.021   14.8   0.0       0.17   11.9   0.0    2.3  2  PAS             PAS fold
      0.049   13.1   0.3       0.19   11.1   0.1    2.0  2  HNOBA           Heme NO binding associated
       0.19   12.3   0.7        6.2    7.4   0.1    2.7  2  DUF3698         Protein of unknown function (DUF3698)


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  178.9   0.0   1.6e-56   7.3e-53       3     181 ..    1309    1488 ..    1307    1490 .. 0.95

  Alignments for each domain:
  == domain 1  score: 178.9 bits;  conditional E-value: 1.6e-56
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevave 95  
                     ae++ +vt +F+d+vgft+lss+++p ++v +Lne+++ fd+l+d++ ++k+ktiGday +v gl+ +++ +h ++++++++d l+ ++  +++
     EFC38821.1 1309 AERFTDVTCFFSDMVGFTSLSSNMNPSDLVLMLNEIVNGFDDLTDKYTLEKIKTIGDAYFCVGGLHnNSQSDHPERVLRFSIDCLDVIKIHNEN 1402
                     68999*************************************************************667889****************666555 PP

  Guanylate_cyc   96 s.keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfl 181 
                     +   ++++r Gi+tG+vvagviG+kk+ yd+wG+t+n+Asrmest+ ag+i++s++tye  ++ + e++er +vevkGkg  +ty+l
     EFC38821.1 1403 HpDSRINIRLGINTGSVVAGVIGKKKFAYDLWGDTINMASRMESTSLAGRIHISRSTYERVHDLGLEFEER-QVEVKGKGLCQTYLL 1488
                     559*****************************************************************998.69***********98 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.27   1.2e+03      16      62 ..     556     600 ..     555     632 .. 0.71
   2 ?   11.9   0.0   3.8e-05      0.17       3      32 ..    1243    1272 ..    1241    1273 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.27
                 EEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHH CS
         PAS  16 vvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaell 62 
                 v+ ++ ++ y+ +++  ll   r+  + + +  +i + ++  ++++ 
  EFC38821.1 556 VTMANDIVQYCDQTFSVLLSRGRDKTILRYYANYIETVKM--DKDAA 600
                 56678899*****************999999999987666..33333 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 3.8e-05
                  HHHHHHHSSSEEEEEETTSBEEEECHHHHH CS
         PAS    3 lraileslpdpifvvDedgrilyvNaaaee 32  
                  + ++l+s+ d+ f+ +e+g+++++N+aa++
  EFC38821.1 1243 MNNLLDSMVDGAFLSNERGEVVLFNKAAQK 1272
                  6789************************96 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.32   1.4e+03     131     154 ..     460     483 ..     457     491 .. 0.87
   2 ?   11.1   0.1   4.2e-05      0.19     192     221 .]    1272    1301 ..    1239    1301 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.32
       HNOBA 131 nsllFlcsPvvenleelrkvGlyl 154
                   +lFlc   ++++ +++   l l
  EFC38821.1 460 TGMLFLCATAISKVRDIQSLSLTL 483
                 579************999988876 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 4.2e-05
       HNOBA  192 eesmkeleeekkrtdeLLysmiPkevAerL 221 
                  +++ + l eekk +++LL +++P+ vA++L
  EFC38821.1 1272 KKQKALLAEEKKNSEALLRNILPEAVASKL 1301
                  5667789********************987 PP

>> DUF3698  Protein of unknown function (DUF3698)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.1    0.0014       6.2      17      85 ..      13      78 ..       4      88 .. 0.84
   2 ?    2.0   0.1     0.064   2.9e+02      38      85 ..    1219    1266 ..    1194    1274 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0014
     DUF3698 17 eneeadalktpeilfevGdYktenycleqGleelkvaikdfkqklkekLksieeedlfeDkeWsprvlf 85
                 ++ +++  t+++   vG   + ++ le G ++    i++f++k++++L + ++++ ++   W   +l+
  EFC38821.1 13 GQNMMNS-STMDSQSIVGQSTQFSFELESGTDQQPDLISSFNEKITGHLTDLQSNSSYN--GWKSMILY 78
                4555566.89**********************************************997..47777776 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.064
     DUF3698   38 tenycleqGleelkvaikdfkqklkekLksieeedlfeDkeWsprvlf 85  
                   +n+++  G++  kva k+  ++  ++L ++  +  f  +e    vlf
  EFC38821.1 1219 IKNFIFFNGFKSEKVAKKEEDENSMNNLLDSMVDGAFLSNERGEVVLF 1266
                  5789999*************9999999988888888888777777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1092  (0.0609069); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.85u 0.29s 00:00:01.13 Elapsed: 00:00:00.48
# Mc/sec: 9512.00
//
Query:       EFC38822.1  [L=1023]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-12   48.1   1.1    8.5e-12   45.5   1.1    2.4  1  PH        PH domain


Domain annotation for each model (and alignments):
>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.5   1.1   4.7e-16   8.5e-12       2     102 ..     906    1007 ..     901    1009 .. 0.90

  Alignments for each domain:
  == domain 1  score: 45.5 bits;  conditional E-value: 4.7e-16
                  EEEEEEEEETSSSSCSEEEEEEEEETTEEEEESST..TCTTESSEEEEEESTTEEEEEEEC.TT.SSSSTSEEEEEESTSSSTEEEEEEESSHHHHH CS
          PH    2 vkeGwLlkkgsgkkkswkkrwfvLkdsellyyknd..ksekdkepkgsislsncevvevva.te.dpkrkfcfelriverngsrtyllqasseeerk 94  
                  +++G+ lk+g+ +k sw +r+f L+ + + y++ +  ks k+k++k++i+ +++++v+ ++ ++ ++++++ f+l +v  +++rt++ + ss+ee+ 
  EFC38822.1  906 ICDGMGLKQGKLRK-SWTERYFLLTIEYFGYFQIKttKSLKKKKMKNTIPSDTIDYVKQNTdDKfTSNKNYPFCLEVV--CKKRTFYVCYSSQEELD 999 
                  57788889999999.**********9999999999***********************99996669999999999999..6679************* PP

                  HHHHHHHH CS
          PH   95 eWikaiqs 102 
                  +W +a++ 
  EFC38822.1 1000 RWDAAFEY 1007
                  **888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1023 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1791  (0.099894); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.84u 0.33s 00:00:01.17 Elapsed: 00:00:00.51
# Mc/sec: 6079.99
//
Query:       EFC38823.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.4e-06   25.8   0.0    0.00018   20.5   0.0    2.2  2  UDPGT            UDP-glucoronosyl and UDP-glucosyl transferas
      4e-05   23.7   0.0      9e-05   22.5   0.0    1.6  1  Glyco_transf_28  Glycosyltransferase family 28 N-terminal dom


Domain annotation for each model (and alignments):
>> UDPGT  UDP-glucoronosyl and UDP-glucosyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.8   0.0    0.0044        40     242     287 ..     235     280 ..     224     288 .. 0.80
   2 !   20.5   0.0     2e-08   0.00018     337     434 ..     365     466 ..     353     469 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.0044
       UDPGT 242 pllpnvefigglnck.pakplpkeleefvqssGehGvvvfSlGsmvs 287
                     n++ ig l+ k +++ l  e+eefv+  G++  +++S+Gsm  
  EFC38823.1 235 GYRDNINLIGYLELKlENEKLESEIEEFVKD-GKEKPIFLSFGSMPA 280
                 5566888899888872456799********9.8888889******65 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 2e-08
       UDPGT 337 gHPktkAFvtHaGangvyEaisnGvPmvglPlFgdqrdNikrmeakg.aavtlnvkemtsedllnAlkevindks...ykenimrLsslhkDrPvkPLD 431
                   Pk      H Ga +   a+  G+P + lP+F dq+  ++rm+  g a   + +k +t+e +++ ++ v++ +     ke + ++ +      v+PL 
  EFC38823.1 365 LFPKCSCIAHHCGAGTTGTALIAGIPQIPLPVFMDQPFWAQRMHDLGvASPPIPFKDITNEKINSSIEFVLESDEsqrIKERASEIKNQIAKEDVNPLS 463
                 56888888999****9*****************************99345579******************8654011344444444434445677776 PP

       UDPGT 432 rav 434
                 r+v
  EFC38823.1 464 RSV 466
                 665 PP

>> Glyco_transf_28  Glycosyltransferase family 28 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   0.0     1e-08     9e-05       3      73 ..       6      75 ..       4      97 .. 0.77

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 1e-08
                     EEE-SSHHHHHHHHHHHHHHHCTT-EEE.EEEETCCCHHHHHHCCT-EEEE---GHCTT..CHHHHCCHHHH CS
  Glyco_transf_28  3 llggGTgGhvfPalAlakeLkkegheVr.ylgtkrgleerlveeaglefepiageklrrklspknlkeilkv 73
                     +l++GT+G+++P+ A+a eL+++ ++ + yl++++ +++   e+   +  ++a++ l+ ++  +n+ke+++ 
       EFC38823.1  6 VLTIGTRGDFQPMFAFALELQQQLVDDQvYLIASEIYRNNY-ESILQQSNKLAAR-LQFRGLSGNPKETMQD 75
                     79*********************866557899999998887.6666677777777.5555566666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       860  (0.047967); expected 358.6 (0.02)
Passed bias filter:                      642  (0.0358079); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2871.05
//
Query:       EFC38824.1  [L=1961]
Description: serine/threonine protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.9e-52  177.6   4.8    7.4e-27   94.4   0.7    3.0  2  Pkinase      Protein kinase domain
    2.3e-43  148.4   5.1    1.1e-21   77.3   0.4    4.3  4  Pkinase_Tyr  Protein tyrosine kinase
      4e-06   26.5   3.5      0.017   15.2   0.0    4.8  4  LRR_6        Leucine Rich repeat
    0.00079   19.1   0.7    0.00079   19.1   0.7    4.0  4  LRR_8        Leucine rich repeat
     0.0058   16.0   0.0      0.011   15.1   0.0    1.3  1  DUF4135      Domain of unknown function (DUF4135)
  ------ inclusion threshold ------
       0.14   12.7   0.1       0.14   12.7   0.1    6.3  7  LRR_4        Leucine Rich repeats (2 copies)
       0.42   10.3   1.6        2.6    7.7   0.1    2.9  2  Apo-CIII     Apolipoprotein CIII (Apo-CIII)
       0.63   10.3   3.5       0.87    9.9   1.2    2.6  2  DUF5439      Family of unknown function (DUF5439)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.9   0.2   5.3e-27   1.2e-23       3     260 ..      23     274 ..      21     276 .. 0.84
   2 !   94.4   0.7   3.3e-30   7.4e-27      48     259 ..    1686    1953 ..    1659    1956 .. 0.77

  Alignments for each domain:
  == domain 1  score: 83.9 bits;  conditional E-value: 5.3e-27
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE.....SSEEEEEEE--TTEBHHHHHHHHSS- CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee.....kdelylvleyveggeladllerkgsl 95 
                 k++ + +G++G Vyk++  ++++ +A+K+++++   + +e  +l E   ++k+k  ++ivr+ evf         +l++ +e++e g+l ++ + +++ 
  EFC38824.1  23 KEQLIATGTYGAVYKIL--KNNNYIALKIMRHSVGFNINE--ALGEAVKMAKYKhKRHIVRIDEVFIVnecksGLYLCIEMEFCEFGTLSTIFR-DSKP 116
                 5788999**********..7999**********9999886..9*****9****94469******997766733445556799**********97.6889 PP

                 -HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEET.TTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHH CS
     Pkinase  96 seeeakkiakqilegleylH.skgiiHrDlKpeNiLide.kge....lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvily 188
                 se+ +  i+kqi+ +l+ +    +i+H D+K +NiL+ + +g     + +tDFGl+  ++ ++      + s Y +PE +     s  +D+++lG  +y
  EFC38824.1 117 SEQVLCTILKQICLALKEIQeGDSIVHNDIKANNILVRSfDGGmnidVALTDFGLSFSVDGQN----HDIMSLYPPPEEV----ASFGSDIFTLGACMY 207
                 *******************95567**************533324667************9976....667789*****99....7899*********** PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellq 260
                 +l+  k     + g+ ++++ +    + +k  ++   +l e  + s+ +  ++ ++++k+ + R+ ++ ll+
  EFC38824.1 208 KLMIDKSTVF-RYGNFNFANLC----QDTKFEETIIRDLCEIGQYSQRLATIIISMMNKEVSARPNIDTLLN 274
                 *998776555.24444344444....4467777888899999999*********************999886 PP

  == domain 2  score: 94.4 bits;  conditional E-value: 3.3e-30
                  HHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTT..EE-SS-SGGGEEEETTTE.EEE-S CS
     Pkinase   48 EikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseeeakkiakqilegleylHskg..iiHrDlKpeNiLidekge.lKitD 141 
                     +  +l+hpni rl+++++ +d+ + ++++++ + l+++++   s+s ++  +++  i++g++ylHs +  + +rDl  +Ni+i+e+++  Ki  
  EFC38824.1 1686 QQDLWLSLDHPNISRLIGSVKLNDSELYITDLANYN-LKEVIS---SISLSQKLEYLIDIAKGMNYLHSLNppVAFRDLRLSNIIISENEDcAKIYG 1778
                  55677799*************99999999****966.*****8...69999999**************99999**************77777***** PP

                  GTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHT.HHHHHHHCTSHH...HHHTTS.... CS
     Pkinase  142 FGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldq.lekilkilgetkeklpeasei.... 233 
                  F+la++++++  ++  vg+  Y+APEvlk  +ys+k+Dv+s +++l+e+++g p f + +  +++ k   + ++++++i +  + +l+    i    
  EFC38824.1 1779 FDLATNVQKH--MSILVGSYVYIAPEVLKLDDYSEKCDVYSFAILLWEVVMGIPTFDSYEPIKQFLKRNSKyVKMTINIEQ-PTTSLE----Ilkrk 1868
                  *******996..79*******************************************666555554444442333333333.222222....12333 PP

                  ...........................................................-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase  234 ...........................................................seeakdllkkllkkdpkkRltaeell 259 
                                                                                +  l +++++ + + R++++e+l
  EFC38824.1 1869 ppcipflldsdyakysithldspprkyvfipelldrfvkefmfsqveeypenletiknvVYGLSVLATRCWENNSNIRPSFREIL 1953
                  5567777777777777777777777777777777777777777777777777777766666666677777777777777777776 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.9   0.1     1e-19   2.3e-16       4     257 ..      24     274 ..      22     276 .. 0.78
   2 ?    0.1   0.0      0.17   3.9e+02     193     242 ..     708     756 ..     705     763 .. 0.86
   3 !   77.3   0.4   4.9e-25   1.1e-21      45     225 ..    1680    1852 ..    1650    1868 .. 0.78
   4 !    9.2   0.0   0.00029      0.64     222     259 .]    1919    1956 ..    1902    1956 .. 0.79

  Alignments for each domain:
  == domain 1  score: 59.9 bits;  conditional E-value: 1e-19
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE....SSSS...EEEEEE--TTEBHHHHHH CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvct....keep...llivteyvkgGdLlkfLr 93 
                  ++ ++ G++G V++   +      +  +a+K+++++   +  +e l ea  m k+ ++++iv++  v +    k  +   l+i +e+++ G+L++  r
   EFC38824.1  24 EQLIATGTYGAVYKILKN------NNYIALKIMRHSVGFN-INEALGEAVKMAKYkHKRHIVRIDEVFIvnecK--SglyLCIEMEFCEFGTLSTIFR 112
                  567899******997766......889******9988887.7778888888888856789***99998864331..15559999************** PP

                  HTCTTTSBHHHHHHHHHHHHHHHHHHHHTT.EEEST-SGGGEEEEE.....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHH CS
  Pkinase_Tyr  94 kkekekltlkdllsfalqvAkGmeyLeskk.lvHrdlaarNvLlse.....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsk 185
                  ++   k + + l+ +  q++ +++ +++ + +vH d+ a N+L+++     n  v ++DfGL+ ++       + +++++   + +pE +     +  
   EFC38824.1 113 DS---KPSEQVLCTILKQICLALKEIQEGDsIVHNDIKANNILVRSfdggmNIDVALTDFGLSFSV-------DGQNHDIMSLYPPPEEV----ASFG 196
                  98...888999**************9875449*************999988899**********99.......66777888889999976....5789 PP

                  HHHHHHHHHHHHHHTTSSGT.......TTTS.HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 186 sDvWsfGvllwEiftlgesp.......ypgl.kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselve 257
                  sD++  G +++ ++   ++        +++l +++++ e++ +   l +  + +++l++++ + ++++ + Rp++ +l++
   EFC38824.1 197 SDIFTLGACMYKLMIDKSTVfrygnfnFANLcQDTKFEETIIR--DLCEIGQYSQRLATIIISMMNKEVSARPNIDTLLN 274
                  ***********98764333222111114444344444444422..24455667899******************999876 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.17
                  HHHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT CS
  Pkinase_Tyr 193 vllwEiftlgespypglkneevleklkegkrlekpekcpeelyelmkkcw 242
                   ++wE f l+ s++++ ++++++++lk+ ++l k +  +++l++l ++c+
   EFC38824.1 708 SIIWEDFDLSFSSFSESTATTIMQMLKKIQNLLKEN-KHSTLKDLFSSCY 756
                  579***********************9999887755.6889999999997 PP

  == domain 3  score: 77.3 bits;  conditional E-value: 4.9e-25
                   HHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEE CS
  Pkinase_Tyr   45 keelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlse 138 
                   + e +++ ++  +l+hpni +l+g +  +++ l +t+++++ +L++ + +     ++l+++l++ +++AkGm+yL+s +  +  rdl+  N+++se
   EFC38824.1 1680 NFEHYKQQDLWLSLDHPNISRLIGSVKLNDSELYITDLANY-NLKEVISS-----ISLSQKLEYLIDIAKGMNYLHSLNppVAFRDLRLSNIIISE 1769
                   34456677788899*************99998999999887.67777655.....7********************9987799************9 PP

                   TT.EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTS.HHHHHHHHHHTTEES- CS
  Pkinase_Tyr  139 nk.vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypgl.kneevleklkegkrle 225 
                   n+ ++ki  f La ++     +++ +    ++ ++apE+lk   +++k Dv+sf++llwE++  g  ++ ++   +++l++ ++  +++
   EFC38824.1 1770 NEdCAKIYGFDLATNV-----QKHMSILVGSYVYIAPEVLKLDDYSEKCDVYSFAILLWEVVM-GIPTFDSYePIKQFLKRNSKYVKMT 1852
                   77599***********.....444555677899****************************98.6666666633444554444444444 PP

  == domain 4  score: 9.2 bits;  conditional E-value: 0.00029
                   EES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  222 krlekpekcpeelyelmkkcweedpeeRptfselvekl 259 
                   ++le+ +++   l  l ++cwe++ + Rp+f+e++e+l
   EFC38824.1 1919 ENLETIKNVVYGLSVLATRCWENNSNIRPSFREILENL 1956
                   55677777777888899*****************9986 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1      0.19   4.4e+02       5      14 ..    1353    1362 ..    1349    1369 .. 0.81
   2 !    6.0   0.1    0.0062        14       3      17 ..    1557    1571 ..    1555    1572 .. 0.90
   3 !   15.2   0.0   7.4e-06     0.017       3      23 ..    1581    1601 ..    1579    1602 .. 0.89
   4 ?    0.1   0.0      0.52   1.2e+03       3      13 ..    1605    1615 ..    1603    1619 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.19
       LRR_6    5 LteLdLsgNd 14  
                  +t+LdL+g++
  EFC38824.1 1353 ITSLDLRGCK 1362
                  79*******8 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0062
       LRR_6    3 thLteLdLsgNdIgD 17  
                   +Lt+L++s  +I+D
  EFC38824.1 1557 KNLTSLNVSNTQIDD 1571
                  58************9 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 7.4e-06
       LRR_6    3 thLteLdLsgNdIgDeGaeaL 23  
                  ++++ L++s+N+IgD+G+e L
  EFC38824.1 1581 SNIENLSVSYNQIGDDGIEYL 1601
                  78899*************987 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.52
       LRR_6    3 thLteLdLsgN 13  
                   +L+ Ld++gN
  EFC38824.1 1605 KNLQRLDVRGN 1615
                  58********9 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.1       5.4   1.2e+04      45      60 ..    1185    1200 ..    1182    1202 .. 0.51
   2 ?    1.3   0.1      0.13     3e+02      19      59 ..    1318    1361 ..    1316    1362 .. 0.76
   3 !   13.7   0.7   1.8e-05      0.04       1      61 []    1533    1593 ..    1533    1593 .. 0.95
   4 !   19.1   0.7   3.5e-07   0.00079       2      59 ..    1558    1615 ..    1557    1616 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 5.4
                  GTT--S-.EEE--SS- CS
       LRR_8   45 fsgLpsLrsLdLsgNr 60  
                  f+ ++ L++L +s+ +
  EFC38824.1 1185 FRKFHLLQKLLVSYSK 1200
                  5555555555555443 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.13
                  TSSTT-TT--EEE--SS..---GGGGGGG.TT--S-.EEE--SS CS
       LRR_8   19 eaFkglsnLkvLdLsnN..llttlspgaf.sgLpsLrsLdLsgN 59  
                  ++F++ s ++   L++N  + +++s++ f + Lp ++sLdL+g+
  EFC38824.1 1318 KVFTTTSPVQLVALNSNilNSQHISNHFFiEKLPLITSLDLRGC 1361
                  56777788888888888555566888877468*********997 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 1.8e-05
                  TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8    1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61  
                  ++L++L++   +l+  +    ++++nL++L+ sn +++    + +s +++++ L +s+N++
  EFC38824.1 1533 RSLKTLSIEGRKLSQHSIIIISQMKNLTSLNVSNTQIDDPMTQIISTMSNIENLSVSYNQI 1593
                  6899***********************************889*****************97 PP

  == domain 4  score: 19.1 bits;  conditional E-value: 3.5e-07
                  T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8    2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59  
                  nLtsL++sn+++ +   +  +++sn + L+ s+N++     + ++++++L+ Ld++gN
  EFC38824.1 1558 NLTSLNVSNTQIDDPMTQIISTMSNIENLSVSYNQIGDDGIEYLVSMKNLQRLDVRGN 1615
                  9*************************************999****************9 PP

>> DUF4135  Domain of unknown function (DUF4135)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   4.9e-06     0.011     138     178 ..    1051    1095 ..    1050    1135 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 4.9e-06
     DUF4135  138 raGallallyllggtDlheeNliasgeqpvliDlEtllth....e 178 
                  + G l+  + ll+ +D  e+N i +g+q+v+iD E ++ +    +
  EFC38824.1 1051 NTGLLIVCSMLLNPEDQKEDNFILAGNQLVPIDNEHVFLPgsvlS 1095
                  6799999******************************97743330 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.2      0.02        45       4      31 ..    1354    1385 ..    1351    1392 .. 0.85
   2 ?   -2.5   0.6       3.5   7.8e+03      14      39 ..    1410    1434 ..    1403    1440 .. 0.67
   3 ?   -1.2   0.0       1.4   3.1e+03      13      33 ..    1515    1543 ..    1507    1549 .. 0.60
   4 ?   10.0   0.7   0.00043      0.96       3      38 ..    1535    1571 ..    1533    1575 .. 0.70
   5 ?   12.7   0.1   6.1e-05      0.14       2      33 ..    1582    1615 ..    1581    1620 .. 0.84
   6 ?   -3.0   0.2       5.3   1.2e+04      12      39 ..    1721    1751 ..    1716    1753 .. 0.47
   7 ?   -2.1   0.2       2.7   6.1e+03      19      30 ..    1949    1961 .]    1941    1961 .] 0.55

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.02
                  -EEE--SS.---E-S-..HHH.-TT--EEE-. CS
       LRR_4    4 evLdLsnN.qltdipl..lek.lpnLkeLdLs 31  
                  ++LdL+++ +l++ +l  l+k + n ++L++s
  EFC38824.1 1354 TSLDLRGCkNLQEESLfiLQKyCVNVEYLNIS 1385
                  89****8878**9999777788********96 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 3.5
                  -E-S-HHH-TT--EEE-.-S.-----G CS
       LRR_4   14 tdiplleklpnLkeLdLsgN.nlitdl 39  
                  tdi+ +  +p L+ L L +N + ++++
  EFC38824.1 1410 TDINIPI-FPYLQILIL-DNiPTLKSI 1434
                  4777777.888888877.541444555 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.4
                  --E-S-..HH......H-TT--EEE-.-S CS
       LRR_4   13 ltdipl..le......klpnLkeLdLsgN 33  
                  l + ++  ++      k+ +Lk+L++ g 
  EFC38824.1 1515 LEEESFplFYltitcmKFRSLKTLSIEGR 1543
                  55555533225566767899***999664 PP

  == domain 4  score: 10.0 bits;  conditional E-value: 0.00043
                  --EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4    3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38  
                  L++L++ + +l+  +   +++++nL++L++ +N++i+d
  EFC38824.1 1535 LKTLSIEGRKLSQHSIiiISQMKNLTSLNV-SNTQIDD 1571
                  666666655666655543446*********.7778865 PP

  == domain 5  score: 12.7 bits;  conditional E-value: 6.1e-05
                  S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4    2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33  
                  n e+L+ s Nq+ d +   l +++nL+ Ld+ gN
  EFC38824.1 1582 NIENLSVSYNQIGDDGIeyLVSMKNLQRLDVRGN 1615
                  889**********844466779*********887 PP

  == domain 6  score: -3.0 bits;  conditional E-value: 5.3
                  ---.E-S-HHH-TT--E.EE-..-S-----G CS
       LRR_4   12 qlt.diplleklpnLke.LdL.sgNnlitdl 39  
                  +l+  i++++   +L++ +d+  g+n++ +l
  EFC38824.1 1721 NLKeVISSISLSQKLEYlIDIaKGMNYLHSL 1751
                  4443444433145577733345556666655 PP

  == domain 7  score: -2.1 bits;  conditional E-value: 2.7
                  HHH.-TT--EEE- CS
       LRR_4   19 lek.lpnLkeLdL 30  
                  ++  l nL+ L+L
  EFC38824.1 1949 FREiLENLTNLHL 1961
                  4444666666665 PP

>> Apo-CIII  Apolipoprotein CIII (Apo-CIII)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.1    0.0012       2.6      36      61 ..     421     445 ..     407     457 .. 0.88
   2 ?   -0.5   0.1      0.44   9.9e+02      32      66 ..    1132    1167 ..    1120    1169 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0012
    Apo-CIII  36 qqArgWvtdslssLkdYwstfkgkfs 61 
                 ++A +Wv ++++ L+dY+s+++ k+ 
  EFC38824.1 421 EKALEWV-EKIQKLEDYYSSYATKLR 445
                 68999*9.58************9985 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.44
    Apo-CIII   32 sqvaqqArgWvtdslssLkdYwstfkgkfs.gfwds 66  
                  ++v q  ++W+ + +     Y s f+   s ++w+ 
  EFC38824.1 1132 MNVDQFLQQWMGELVVVNDKYSSLFTKEESdNLWEN 1167
                  566677789**9988888888888888888789986 PP

>> DUF5439  Family of unknown function (DUF5439)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       6.5   1.5e+04      24      39 ..     141     156 ..     138     162 .. 0.83
   2 ?    9.9   1.2   0.00039      0.87       9      66 ..     811     872 ..     805     876 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 6.5
     DUF5439  24 ishrntkvnnliiedy 39 
                 i h + k nn+++  +
  EFC38824.1 141 IVHNDIKANNILVRSF 156
                 78999*****999766 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00039
     DUF5439   9 wyiwkefyqsrnkrlishrntkvn..nlii..edysvtivinwysiiiidkvlfihdvmfic 66 
                 w +++e+  s+ + +i + ++ ++   l+   +  s+t v+   si+i dk++fi dv   c
  EFC38824.1 811 WSLFHEYILSQVRLMINYEDAVLQfhSLLFmkNKLSLTNVLVSLSIMINDKLVFIRDVKTAC 872
                 777888888888777877776543114433126789**********************9888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1961 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1032  (0.0575604); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.04u 0.34s 00:00:01.38 Elapsed: 00:00:00.52
# Mc/sec: 11337.15
//
Query:       EFC38825.1  [L=204]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.67   10.0  13.2         11    6.2  11.7    2.3  1  DUF3671   Protein of unknown function
        6.2    7.2   9.0         51    4.3   9.0    2.3  1  2TM       2TM domain


Domain annotation for each model (and alignments):
>> DUF3671  Protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2  11.7    0.0012        11      15     107 ..      53     187 ..      40     188 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0012
     DUF3671  15 iFdkid..kidelakkknndkkkfkkk.vlkkyglllilpvllpliglivpilfeaksk........................................ 70 
                 +F++i   ++d++ k+ nn+++++ ++ ++kk    + ++v+++ i++ ++i+ +  ++                                        
  EFC38825.1  53 LFEDIRrtNLDDIPKDWNNKRSTYERLrRIKKE--DFETLVMFFFIVVPFLIFTDGGVNsnytygatgaqwsdlsivnsvfgctlilifpvlrlistal 149
                 666664226789999988888888875245664..4567777888888888887776667899999999999999999999999999999999999998 PP

     DUF3671  71 .kslkkkelevlatsieklytiffiilvviillvliYi 107
                    ++k+ ++ +   ++ +y  +fi +++i+++v+ Yi
  EFC38825.1 150 tFFVSKTVVQNVMRIMTMAYFALFILYSFIMIFVFNYI 187
                 744444445567778999999**************998 PP

>> 2TM  2TM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   9.0    0.0057        51       9      57 ..      83     146 ..      75     193 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0057
         2TM   9 eikgFyrhlvvYlivniflili......nl.....gsswf....lwpilfWgiglllhalkvFg 57 
                 ++ +F + ++ ++iv+ fli+       n+     g +w+    +  ++++ ++l++ +l+   
  EFC38825.1  83 KKEDFETLVMFFFIVVPFLIFTdggvnsNYtygatGAQWSdlsiVNSVFGCTLILIFPVLRLIS 146
                 56789999**************665544439999988888544322447777777776666544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (204 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1319  (0.073568); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.35s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1129.87
//
Query:       EFC38826.1  [L=462]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-69  234.9   0.0    6.6e-69  232.9   0.0    1.8  1  Sacchrp_dh_C     Saccharopine dehydrogenase C-terminal domain
    1.8e-21   76.8   0.1    2.7e-21   76.2   0.1    1.3  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
     0.0011   19.0   0.0     0.0021   18.1   0.0    1.5  1  Shikimate_DH     Shikimate / quinate 5-dehydrogenase
     0.0046   17.5   0.0     0.0096   16.5   0.0    1.6  1  F420_oxidored    NADP oxidoreductase coenzyme F420-dependent


Domain annotation for each model (and alignments):
>> Sacchrp_dh_C  Saccharopine dehydrogenase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  232.9   0.0   1.5e-72   6.6e-69       1     262 [.     136     448 ..     136     451 .. 0.88

  Alignments for each domain:
  == domain 1  score: 232.9 bits;  conditional E-value: 1.5e-72
                   BTTTBHHHHHHHHHHHCCCH.TTBECCCCCCCCCCCCECCCCESTTCEEESS-HHHHHHHCCSEEEEEETTEEEECTCCCSGCC.TCEEECCCCC.E CS
  Sacchrp_dh_C   1 GldPGidhllamkaidevka.kggkiesflsycgglpapeasdnplgYkfsWspegvlreltnpakvlengqvkevpgsellkgakkpiyilpgl.s 95 
                   G+dPGidh++a k+i+e ++ kggki+sf+s+cgglp p + dnp++YkfsWsp+gvl +l+n+ak++e+g+++ v+ s+ll++  +++++ + +  
    EFC38826.1 136 GVDPGIDHMIATKIIHEEQDlKGGKIKSFYSWCGGLPHPDHIDNPMKYKFSWSPRGVLMALQNTAKWIEGGEIRVVEPSKLLASR-RELNLAKDMpL 231
                   9***************6666589*************************************************9999999999855.78888544547 PP

                   ECTTECEEECTHCHHHHHHC.SCSEEEEEEEEEHHHHHHHHHHHTTT--SCEC..C......................................... CS
  Sacchrp_dh_C  96 legypnrdslpyeelyglpeaktlfrgtlrypgfsellkslkelGllseepke..e......................................... 149
                   +egypnrds+p++e y+l+ a++++rgtlr++g +e+++ +   Gl + +p +  +                                         
    EFC38826.1 232 FEGYPNRDSTPFKEHYNLKYADDVLRGTLRFKGNCEVVEFFIGAGLVDLTPRPdiKdkqwreimkellgaesveesalsaallkklnlepesekaks 328
                   89*****************99*****************************9665537899*****99999999999999987777777777776665 PP

                   ...CCCCHHST...........T.C.EHHHHHHHHCCHHCCCCTTEEEEEEEEEEEEEE.TTSEEEEEEEEEEEEE.EHHSSSHHHHHHHHHHHHHH CS
  Sacchrp_dh_C 150 ...alkawlse...........g.e.spldvlaalLekklalepgerDlvvlqhefgie.sdgkkkekktstlvgy.deegssamaktvGvpaaiaa 228
                      a                    + + ld+++++L ++++++pgerD+ +++++f+ie ++gkk ++ + +lv++ d e+  +maktvG+p+a+a+
    EFC38826.1 329 athA------FqfyglfsekvaPfKgTLLDTFSQTLLEQMEYKPGERDMLFMCNTFVIEtAEGKK-KTIVAKLVDFgD-ERGMSMAKTVGYPCAVAT 417
                   4441......03444444445425568*************************************8.9999****8753.58899************* PP

                   HHHHTTSCTSSEEEEGGGS.CHHHHHHHHHHHHH CS
  Sacchrp_dh_C 229 klildgkikkrGvvtpeelvdpeiyeplleeLek 262
                   k il+g+i+++Gv++p   ++ +++e +++eL++
    EFC38826.1 418 KKILNGEITTKGVFGP---YEYNMNESIMKELKE 448
                   ****************...8889999******96 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.2   0.1   6.1e-25   2.7e-21       1     128 [.      10     130 ..      10     132 .. 0.95

  Alignments for each domain:
  == domain 1  score: 76.2 bits;  conditional E-value: 6.1e-25
                      EEEE--SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHH...TTTCEEEEE--TTTHHHHHHHHHTTSSEEEE-SSGGGHHHHHHHHHH CS
  Sacchrp_dh_NADP   1 vliiGaGsvGqavaellarhfdvdaeitvadrskeklealaaka...lgvrfeaialdaenyeavLaallkegdlvvnlsppissldvlkaCie 91 
                      vl++G+G+v+  ++e l r +  +  +tva+r+++k  +++++     + r  ++ald+en+ + L++l++++dl ++l+p++++  v+kaCi+
       EFC38826.1  10 VLLLGSGFVAGTTLESLTRDGTNT-FVTVASRTLSKSIEMCKEYahdYENRTAQVALDIENEHDKLSELVSQHDLAISLVPYTYHVLVAKACIQ 102
                      79******************9885.9**********9999888799999********************************************* PP

                      HT-EEEESS-BCGCCSCHCCSHHHHHTHHHHHHCTSE CS
  Sacchrp_dh_NADP  92 tgvhyvdtsiskeertnyalreavlklkekakeagvt 128
                      ++ ++v+ts+         +++a+++l++++k+ g+ 
       EFC38826.1 103 HRKNMVTTSY---------ISPALRELDQQFKDLGIA 130
                      **********.........*************99886 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   4.7e-07    0.0021      10      63 ..       5      58 ..       1     110 [. 0.79

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 4.7e-07
                  .TT-EEEEES-SHHHHHHHHHHHCCT-CE.EEEEESSHHHHHHHHHHHT.ET-EE CS
  Shikimate_DH 10 lkekkvlliGaGemaelvakhLlakgvkk.vvvaNRtlerakelaeelkgeeiea 63
                   ++++vll+G G +a  +++ L + g +  v+va Rtl++  e+++e+ ++ +e 
    EFC38826.1  5 TTQHRVLLLGSGFVAGTTLESLTRDGTNTfVTVASRTLSKSIEMCKEYAHD-YEN 58
                  5789********************98765499***************9443.333 PP

>> F420_oxidored  NADP oxidoreductase coenzyme F420-dependent
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   2.2e-06    0.0096       3      81 ..      11     100 ..       9     115 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 2.2e-06
                    EEETTSHHHHHHHHHHHHTTS-GGCEEEEEESSCCCHHHHHHHHC.............-EEECECHHHHHHH-SEEEE-S-HHHHHHHHHHC CS
  F420_oxidored   3 giiGaGnmgealasgllaagaqpheivvansrnpekaeelaeelg.............vkvtavdneeaaeeadvvvlavkpedveevlsel 81 
                     ++G+G ++ + ++ l++ g +++ ++va sr+ +k  e+ +e+              ++ ++ + +e++++ d  +  v+++++  v+++ 
     EFC38826.1  11 LLLGSGFVAGTTLESLTRDG-TNTFVTVA-SRTLSKSIEMCKEYAhdyenrtaqvaldIENEHDKLSELVSQHDLAISLVPYTYHVLVAKAC 100
                    579*****************.77888877.***************99999999999888888888999999999999999988888877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (462 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       524  (0.0292264); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 2601.59
//
Query:       EFC38827.1  [L=272]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.4e-22   78.2   0.6    2.8e-20   73.1   0.0    2.3  2  AAA        ATPase family associated with various cellular act
    1.9e-15   56.6   0.2    7.3e-15   54.7   0.1    2.0  2  Vps4_C     Vps4 C terminal oligomerisation domain
    4.6e-08   32.7   0.0    1.1e-07   31.5   0.0    1.6  1  AAA_lid_3  AAA+ lid domain
  ------ inclusion threshold ------
      0.071   13.1   0.1       0.43   10.6   0.1    2.2  1  AAA_5      AAA domain (dynein-related subfamily)


Domain annotation for each model (and alignments):
>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.1   0.0   6.3e-24   2.8e-20      39     132 .]       1      97 [.       1      97 [. 0.86
   2 ?    3.3   0.1     0.024   1.1e+02      23      88 ..     179     244 ..     166     264 .. 0.82

  Alignments for each domain:
  == domain 1  score: 73.1 bits;  conditional E-value: 6.3e-24
                 TTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH....TTCCCHHHHHHHHHHHHHHHHT.TTSSSTEEEEEEESSGGGSTHHHHSTTSSEEEETTS CS
         AAA  39 vgesekkirelfkeakekakpsilfiDEidalaksr....sgseseeeervvnqLlteldgv.kkkeskvivigatnrpdkldpallrgRfdrkieiel 132
                 +gesek ++ lf+eak+ + p i+fiDEida+++sr     gs++e+ +r+  +Ll ++++v + k+  +ivigatnrp +ldpal+ +Rf+++i+i+l
  EFC38827.1   1 MGESEKLVKTLFEEAKKRQ-PAIIFIDEIDAVGSSReglgGGSSNESISRLKTELLLKVQDVlDMKDTGIIVIGATNRPTDLDPALR-RRFQKRIYIPL 97 
                 59****************9.****************999867777777777777766665551555788******************.7*******985 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.024
                 THEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTS.EEEEEETGGGHHHHHTTCCCHHHHHHHHH CS
         AAA  23 gvefleisgsellskyvgesekkirelfkeakekakp.silfiDEidalaksrsgseseeeervvnq 88 
                 ++++l i+ +e l k+ + ++k+i + +k++k + +p  il + E+ +  +++++  +ee+e++ nq
  EFC38827.1 179 KMNMLDIKQPEKL-KIAKVTAKDIYDSIKSVKPSTNPsEILSFIEFTQNYGESDNPVEEEHEEIENQ 244
                 578999999****.9***************9988878799999888888888866667777777666 PP

>> Vps4_C  Vps4 C terminal oligomerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.68   3.1e+03      43      59 ..     116     132 ..     106     133 .. 0.78
   2 !   54.7   0.1   1.6e-18   7.3e-15       2      61 .]     168     228 ..     167     228 .. 0.95

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.68
      Vps4_C  43 ptVskeDLekheeFTke 59 
                   V++e ++++ + T++
  EFC38827.1 116 VDVTHENIDEFAKLTNQ 132
                 56999999999999987 PP

  == domain 2  score: 54.7 bits;  conditional E-value: 1.6e-18
      Vps4_C   2 tPCspgdpgaiemtwmdipsdklleP.pvtlkDflkalkkarptVskeDLekheeFTkefG 61 
                 +PCs +++++++m++ di++ + l+  +vt kD+ +++k+++p+ +++++  ++eFT+++G
  EFC38827.1 168 VPCSRNEKNSKKMNMLDIKQPEKLKIaKVTAKDIYDSIKSVKPSTNPSEILSFIEFTQNYG 228
                 8******************88777777********************************99 PP

>> AAA_lid_3  AAA+ lid domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.5   0.0   2.6e-11   1.1e-07       3      37 ..     122     156 ..     117     164 .. 0.91

  Alignments for each domain:
  == domain 1  score: 31.5 bits;  conditional E-value: 2.6e-11
   AAA_lid_3   3 dlkeLAerTeGySGADlaalcreAallAlrrgike 37 
                 +++e A++T+ ySGAD+  ++r A +  +r+ + +
  EFC38827.1 122 NIDEFAKLTNQYSGADIGIIIRDALMKPVREAMNS 156
                 79*****************************9874 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   9.6e-05      0.43      64     138 .]      16      89 ..       2      89 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 9.6e-05
                 -..G-SEEEEESGGG--HHHHHHHHHHHHSSEEE..-SSSEEE---.........-EEEEEESS--.-TT-TTHHHHTT- CS
       AAA_5  64 r..egeilvlDEveraesevlnsLlslleerrllleeggelvkaknddller...frviatanpldrslnelspalrsRf 138
                 +  +++i+++DE++ +  +  + L    +++ ++  +   l k++    + +   + vi+++n++     +l+palr+Rf
  EFC38827.1  16 KkrQPAIIFIDEIDAVG-SSREGLGGGSSNESISRLKTELLLKVQDVLDM-KdtgIIVIGATNRPT----DLDPALRRRF 89 
                 34578899999999554.44566667777777775666666666554322.2468**********9....*********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       722  (0.04027); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.53u 0.29s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1708.55
//
Query:       EFC38828.1  [L=565]
Description: peroxisomal acyl-CoA oxidase-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-17   63.7   0.0    2.4e-17   62.9   0.0    1.4  1  Acyl-CoA_dh_M  Acyl-CoA dehydrogenase, middle domain
    7.3e-10   39.2   0.0    1.8e-09   38.0   0.0    1.7  1  Acyl-CoA_dh_1  Acyl-CoA dehydrogenase, C-terminal domain
    6.5e-08   32.3   0.2    1.3e-07   31.3   0.2    1.4  1  ACOX           Acyl-CoA oxidase
  ------ inclusion threshold ------
      0.026   13.9   0.0      0.048   13.0   0.0    1.3  1  DUF3379        Protein of unknown function (DUF3379)


Domain annotation for each model (and alignments):
>> Acyl-CoA_dh_M  Acyl-CoA dehydrogenase, middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.9   0.0   5.3e-21   2.4e-17       1      97 []      78     187 ..      78     187 .. 0.92

  Alignments for each domain:
  == domain 1  score: 62.9 bits;  conditional E-value: 5.3e-21
                    EEE---SS-SS-GGG---EE.EEETT.EEEEE.....EEEEEEETTTT-SEEEEEEE.TS-------EEEEEEE...GG......GEEE-----BS CS
  Acyl-CoA_dh_M   1 afalTEpqaGsdvasvktta.aerdggeyvln.....GeKiwitnaaiatlalvlar.tekpdrarglslflvp.rdap......gvsvrrieekl 82 
                    +f++TE+++Gs+v++++tta ++ +++++++n       K+wi++a+++++ +v+a    + + ++g+ +flvp rd++      gv v+++e kl
     EFC38828.1  78 CFGMTEKGHGSNVRGIETTAtYDPKTQQFIVNtpnpkAMKTWIGGAQYCHFSVVFAHlIIGGE-NKGVHVFLVPmRDRNtqkllpGVYVEDVEYKL 172
                    9**********************************999*******************744555.89********84444679999*********** PP

                    S-TTS-EEEEEEE.. CS
  Acyl-CoA_dh_M  83 Glrglptgelvfedv 97 
                    Gl+g++++ + f++v
     EFC38828.1 173 GLNGIDNYSFGFNNV 187
                    **********99987 PP

>> Acyl-CoA_dh_1  Acyl-CoA dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.0   0.0     4e-13   1.8e-09       7     148 ..     221     375 ..     218     377 .. 0.89

  Alignments for each domain:
  == domain 1  score: 38.0 bits;  conditional E-value: 4e-13
                    HTTTT--S-----..-SHHHHHHHHHHHHHHHTSB-CC-B......GGGSHHHHHHHHHHHHHHHHHHHHHHHHHH--------.......HHHHH CS
  Acyl-CoA_dh_1   7 ametlnheRlavaaaalglarraleealeyarrrkafgkp......lidhqlvreklaemaaeleaarllvyraaealdagkpd.......raeas 89 
                    +   l  +R++++a   ++a+++l  a++ya  rk+fg p      ++++++   +l  + a++ a+ + +  +  ++ +++++          +s
     EFC38828.1 221 TVGELSGGRIVIGAIGNAAAKSCLAIAIKYAFARKQFGPPgkseisIMEYPSHYTRLMPLLARTFAIASGLAYVRDQYRHKHKNaeanaygHCLTS 316
                    5667999*******************************65555666899999999999999998888777777777666666667788999999** PP

                    HHHHHHHHHHHHHHHHHHHHHGGGTTSGGGHHHHHHHHTHHHHHSSS-HHHHHHHHHHH CS
  Acyl-CoA_dh_1  90 maKlfaselaqevadlamqllGgaGyleeypverlyrdarvlrigeGtseiqrniiarr 148
                    ++K  as +    ad + q +GgaG+ + + ++ ++rd+ ++  +eG ++++++++a+ 
     EFC38828.1 317 AIKSAASFHTLHTADICRQACGGAGFRAPNLISGFLRDTHIFVTFEGDNQVLLQQVAKY 375
                    ********************************************************985 PP

>> ACOX  Acyl-CoA oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.3   0.2     3e-11   1.3e-07       6     138 ..     417     549 ..     413     550 .. 0.96

  Alignments for each domain:
  == domain 1  score: 31.3 bits;  conditional E-value: 3e-11
                 HHHHHHHHHHHHHHHHHHHHHHHCTTSCHHHHHHHTHHHHHHHHHHHHHHHHHHHHHHHHTCSSTTCHHHHHHHHHHHHHHHHHHTHHHHHHTTSS-HH CS
        ACOX   6 lealevraarllkeaakkleeekksgkskeeawneqsvelvsaakahaelvvlksfvekleslseelkevLkkLckLyalstiekhlgdflesgylspd 104
                 l +++ r +++++e+ k+l++++++g+++ e++++  v + ++  a+a  ++ +++++  + +  +++  L+ L kL +l +++k+l+ f++ ++l ++
  EFC38828.1 417 LYLFRNREVKMTEELIKRLRDRENRGEDQWESFKNEIVFANELGLAFADRLLHEQLLKDSQLCAFSISGTLSLLSKLNGLAQLQKSLAWFVTNDVLCKN 515
                 667889999***************************************************99************************************* PP

                 HHHHHHHHHHHHHHHHHGCHHHHHHTT---HHHH CS
        ACOX 105 qldllreailellkelrpnavaLvDafdfsDfiL 138
                  ++++ + + +l ke+ +    Lv +fd++ +iL
  EFC38828.1 516 LAKQVDSLVVSLSKEVSKISLDLVESFDIPSNIL 549
                 *****************************98887 PP

>> DUF3379  Protein of unknown function (DUF3379)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   1.1e-05     0.048     155     188 ..     123     155 ..     114     161 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.1e-05
     DUF3379 155 anyCdfegekslHlvlqgekgkvtvfivpeeskv 188
                 a+yC+f+ + + Hl++ ge+  v+vf+vp++++ 
  EFC38828.1 123 AQYCHFSVVFA-HLIIGGENKGVHVFLVPMRDRN 155
                 789***98865.******************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (565 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       442  (0.0246528); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.44
# Mc/sec: 3891.10
//
Query:       EFC38829.1  [L=309]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.031   14.3   0.3        0.1   12.6   0.3    2.0  1  Med31     SOH1
       0.14   12.8   2.6        1.8    9.2   0.8    2.5  2  POTRA     Surface antigen variable number repeat
       0.16   11.9   3.0       0.22   11.5   1.8    1.8  2  MALT1_Ig  MALT1 Ig-like domain
        3.9    7.6  11.0       0.31   11.2   3.4    2.3  2  XLF       XLF-Cernunnos, XRcc4-like factor, NHEJ component


Domain annotation for each model (and alignments):
>> Med31  SOH1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.3   2.3e-05       0.1       2      41 ..     146     185 ..     145     221 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.3e-05
                 HHHHHHHHHHHHHCSHHHHHHTTSSSSSSSTHHHHHHHGG CS
       Med31   2 krFeleleFvqsLanpaYlshLaqekyledeafiaYLkYL 41 
                 ++F+  leF++ L     l++L  +k+ e++af + L+Y 
  EFC38829.1 146 QKFQHALEFIRNLDRDLKLKTLELQKLQEETAFKQSLEYT 185
                 79*************************************7 PP

>> POTRA  Surface antigen variable number repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.047   2.1e+02      21      50 ..     132     158 ..     121     162 .. 0.77
   2 ?    9.2   0.8   0.00041       1.8      17      75 ..     176     231 ..     160     233 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.047
                 TTT.SSSTTSBHCHHHHHHHHHHHHHHHHCT CS
       POTRA  21 rel.elkegdvynpekleadkealksryanl 50 
                   l +++ g+ + ++k++ ++e    +++nl
  EFC38829.1 132 MNLkSTQVGKQFAEQKFQHALE----FIRNL 158
                 4442599**************9....66665 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00041
                 HHHHTTTSSSTTSBHCHHHHHHHHHHHHHHHHCTT-EE.EEEEEEHSSTTSEEEEEEEE CS
       POTRA  17 eelrrelelkegdvynpekleadkealksryanlGyfdasVqvelpeddedknrvdlti 75 
                   +++ le + +++ ++ +l++d  +++s+ ++lG  +a+ ++++   ++ +n+++l++
  EFC38829.1 176 TAFKQSLEYTANKTRDETELSQDFLKIRSFVYSLGIEFAKAVTKN---KDRINEITLDY 231
                 347788888999************************777888888...88888777766 PP

>> MALT1_Ig  MALT1 Ig-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       0.5   2.2e+03      38      61 ..      42      66 ..      30     124 .. 0.54
   2 ?   11.5   1.8   4.9e-05      0.22      56     122 ..     129     197 ..     108     206 .. 0.66

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.5
    MALT1_Ig 38 ekpeeiqdcsatltdfp.edldvdd 61
                e++++i + +  +++    +l+++d
  EFC38829.1 42 EQGKSIDSLQHIIEQQGnLELKMKD 66
                4444444444444443311222222 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 4.9e-05
    MALT1_Ig  56 dldvddklsn..ketseeadslllskedlpdctlytrlssLqkLkeelvfkvkLhytyseleeevtekk 122
                 +++++ k ++  k+  e+     l+   + d  l  +   LqkL+ee +fk  L+yt +++++e++ ++
  EFC38829.1 129 KVKMNLKSTQvgKQFAEQKFQHALEFIRNLDRDLKLKTLELQKLQEETAFKQSLEYTANKTRDETELSQ 197
                 4455554444112333333333344444455555447779*******************9999887665 PP

>> XLF  XLF-Cernunnos, XRcc4-like factor, NHEJ component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.7      0.14   6.2e+02     137     157 ..      37      57 ..       6      75 .. 0.59
   2 ?   11.2   3.4   6.9e-05      0.31      31     121 ..      97     183 ..      91     205 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.14
         XLF 137 lqasaelkrqveeLieilkeK 157
                 +q ++e+ +++++L +i++++
  EFC38829.1  37 IQTAKEQGKSIDSLQHIIEQQ 57 
                 333344444444444444443 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 6.9e-05
         XLF  31 DlanvWseeldrdeilkrakeentsidpsede.eqlavlleklrkaldgskkssaef.slnlsskaeedsLtlkltieLpgplspleWefslv 121
                 Dl  + s++ d+  +  r+ ++ t i+ps++e  +++ +  ++ k++ ++k ++a    +nl++     +L+lk+ +eL+++ +++  + sl+
  EFC38829.1  97 DLDETISCDSDKAVVRTRKRSTATIIKPSDHEkVKMNLKSTQVGKQFAEQKFQHALEfIRNLDR-----DLKLKT-LELQKLQEETAFKQSLE 183
                 888889999**********************98899999999*****44443333223555555.....9****9.9**99988888887777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1213  (0.0676558); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.24s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 2119.79
//
Query:       EFC38830.1  [L=176]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.9    8.3   5.7          5    7.6   5.7    1.6  1  DUF805    Protein of unknown function (DUF805)


Domain annotation for each model (and alignments):
>> DUF805  Protein of unknown function (DUF805)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   5.7   0.00028         5      18      88 ..      12     108 ..       1     172 [. 0.68

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00028
      DUF805  18 lfl.lllvivlallaavlaa....................aavasalsvvlallllvps.lavtvRRlHDtgrsgwllllllvpli....alllllv 88 
                 ++  ++++ivl++ + ++ +                    ++  +++++v+a++ ++ s + ++v+ +HD  + g + ++ l  ++    +l+++++
  EFC38830.1  12 ITRkVICYIVLSIYSLACLStcglnigcavtfprdcefqfSVRLDIVISVFAFINFLSSvAVLIVQIIHDSQKMGPITIVRLRIVLylctTLMFMFT 108
                 43336666666666666655777888888889999997664444444444444444444577889***********765444432222222233333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       656  (0.0365888); expected 358.6 (0.02)
Passed bias filter:                      244  (0.0136092); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.24s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 1283.89
//
Query:       EFC38831.1  [L=845]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.9e-72  236.8  18.3    3.3e-15   55.5   0.3    6.7  6  DUF4116       Domain of unknown function (DUF4116)
    4.5e-25   88.5   7.1    4.5e-25   88.5   7.1    3.3  3  Pkinase       Protein kinase domain
    2.2e-08   33.7   0.2    6.9e-08   32.1   0.2    1.9  1  Pkinase_Tyr   Protein tyrosine kinase
  ------ inclusion threshold ------
      0.081   12.9   2.3       0.36   10.9   0.0    2.9  3  LOH1CR12      Tumour suppressor protein


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3   0.3   1.8e-13   8.2e-10       9      49 .]      21      62 ..      13      62 .. 0.86
   2 !   55.5   0.3   7.5e-19   3.3e-15       1      49 []      64     112 ..      64     112 .. 0.99
   3 !   50.2   0.1   3.4e-17   1.5e-13       1      47 [.     114     160 ..     114     163 .. 0.97
   4 !   46.7   0.0   4.1e-16   1.8e-12       1      48 [.     164     211 ..     164     212 .. 0.97
   5 !   54.8   0.1   1.3e-18   5.7e-15       1      49 []     215     263 ..     215     266 .. 0.98
   6 ?   -3.5   0.1       2.1   9.3e+03      16      29 ..     465     474 ..     454     475 .. 0.60

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 1.8e-13
     DUF4116  9 vk.kngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                +k +++s+l++++e Lk+D+e+vl+ +k++g+al+ya+e+L+
  EFC38831.1 21 IKwNDCSCLEKVNETLKKDREFVLETIKKHGSALEYADESLK 62
                5535689********************************997 PP

  == domain 2  score: 55.5 bits;  conditional E-value: 7.5e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE++l avk+ng++++y++e++k+D+eivl+  k n +al+ya+++L+
  EFC38831.1  64 DREFILTAVKTNGNSFRYIDEKFKKDREIVLEGFKENLSALEYADKSLK 112
                 9*********************************************997 PP

  == domain 3  score: 50.2 bits;  conditional E-value: 3.4e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 Dr+++l avk+ng+al+++++ Lk+D+ ivl+Avk   +a++ya ++
  EFC38831.1 114 DRDFMLTAVKQNGLALQHADKLLKKDRKIVLEAVKEKAYAFKYANKS 160
                 9*******************************************886 PP

  == domain 4  score: 46.7 bits;  conditional E-value: 4.1e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrE++lea+++n++a+ +++ ++k+D++++l Avk+ng al y+ ++L
  EFC38831.1 164 DREFMLEAIESNPYAFGNANVSFKKDRQFMLDAVKRNGLALHYYQDDL 211
                 9******************************************99887 PP

  == domain 5  score: 54.8 bits;  conditional E-value: 1.3e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivleavk+ng++lk+lse++++D+e+v +A ++ ++al+yas +Lr
  EFC38831.1 215 DREIVLEAVKTNGKILKHLSESFRKDREVVFQAFQNWKKALKYASASLR 263
                 9********************************************9887 PP

  == domain 6  score: -3.5 bits;  conditional E-value: 2.1
     DUF4116  16 lkylseeLknDkei 29 
                 ++y+    +nD ++
  EFC38831.1 465 YNYF----SNDYDF 474
                 4443....355555 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0       0.1   4.5e+02      53      83 ..     295     329 ..     273     361 .. 0.74
   2 !   88.5   7.1     1e-28   4.5e-25       1     256 [.     472     774 ..     472     779 .. 0.79
   3 ?   -1.9   0.3      0.37   1.7e+03      58     103 ..     795     840 ..     786     843 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.1
                 HHHS...CTTB--EE.EEEEESSEEEEEEE--TTE CS
     Pkinase  53 kklk...hpnivrly.evfeekdelylvleyvegg 83 
                  kl+   + ni+ +y ++f++++ely +le+ +++
  EFC38831.1 295 SKLQtklSTNIIDIYsKSFSDENELYYCLELPKNN 329
                 333333588999988358999********998876 PP

  == domain 2  score: 88.5 bits;  conditional E-value: 1e-28
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHH.HHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HH CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrE.ikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslsee 98 
                 y  ++ lG+G+ G+V+k+++k+++   AvK   + ++++++     +E +k+l++ +    ++++++   +++ly v+e+ e ++lad+++r+  + ++
  EFC38831.1 472 YDFISILGHGGEGVVLKVFHKSSRSLRAVKFKYNTEESEESG----NElLKLLRRKDLTGKINYFDCGMIHNHLYSVMELGE-ESLADYISRNFEIYMN 565
                 567789************************988888887665....452578888888888999999999***********9.67******77766666 PP

                 ..........HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.................T CS
     Pkinase  99 ..........eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl.................k 170
                           e+ +i+ ++le+++ +H+++i+HrDl p+Ni    ++e Ki+DF  +k ++++++ t   g   Y++PEv                   
  EFC38831.1 566 rtakskdkliEILQIFIKVLESVKSIHDHNILHRDLDPQNIVKI-QDEYKIIDFETSKVIKTGNSITIARGKYSYMSPEVShdsytddmlkngdemklA 663
                 6677778888999****************************988.999********************************9988888777766555441 PP

                 T..SCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHT...HHHHHHHCT........SHH...HHHTTS......................- CS
     Pkinase 171 e..neyskkvDvWslGvilyelltgkppfsgekgkekvekeldq...lekilkilg........etkeklpeasei......................s 234
                 +   +++ ++D++slG+il++llt+ p+    +++  + +++ +    ++ +++ g        +        se                       +
  EFC38831.1 664 HniGNITISCDLFSLGCILLKLLTNVPLQL--DEQFIHDSDISKyndNFTYFNVYGkyfftvvtT--------SEGemklhyaieklinssimeeygvN 752
                 1447889***************99887755..333333344444112455556665554433332........22233445555888899999988888 PP

                 HHHHHHHHHHT-SSGCCSTTHH CS
     Pkinase 235 eeakdllkkllkkdpkkRltae 256
                 + +++ +  ++++d +kRl+++
  EFC38831.1 753 HLLIRCIITMIQRDSSKRLSCR 774
                 8889999999999999999875 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.37
                 TTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHH CS
     Pkinase  58 pnivrlyevfeekdelylvleyveggeladllerkgslseeeakki 103
                 ++i  ++e+++ k++  l+ e  + +e +++le+k ++ eee++k+
  EFC38831.1 795 KEITDYKEIISLKSYSQLIEENKKLNENQKALEEKIKILEEEIRKW 840
                 5677788888888888888888888888888888888888888775 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.2   1.5e-11   6.9e-08       4     195 ..     475     682 ..     472     700 .. 0.78

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 1.5e-11
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT...... CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk...... 95 
                   + lG+G  G V +   k    +++   avK   ++  ee++e+  e +k++++ +    +++  + + +++l+ v+e+ ++ +L +++ ++      
   EFC38831.1 475 ISILGHGGEGVVLKVFHK----SSRSLRAVKFKYNT--EESEESGNELLKLLRRKDLTGKINYFDCGMIHNHLYSVMELGEE-SLADYISRNfeiymn 565
                  567999999999998887....55555677765332..222345555678899999999999999999999*******9775.899999999999999 PP

                  ..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.......... CS
  Pkinase_Tyr  96 ..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.......... 181
                    +k+k +l ++l++ ++v + ++ +++++++Hrdl  +N+ ++ ++  ki Df  ++ i   ++ ++ + a+  + +m+pE+ +++           
   EFC38831.1 566 rtAKSKDKLIEILQIFIKVLESVKSIHDHNILHRDLDPQNI-VKIQDEYKIIDFETSKVI---KTGNSITIARGKYSYMSPEVSHDSYtddmlkngde 659
                  9899999999******************************9.6779999***********...44455567788899*****9988765555555555 PP

                  .........EEHHHHHHHHHHHH CS
  Pkinase_Tyr 182 .........ftsksDvWsfGvll 195
                           +t + D +s G +l
   EFC38831.1 660 mklahnignITISCDLFSLGCIL 682
                  55555555555555555555555 PP

>> LOH1CR12  Tumour suppressor protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       2.4   1.1e+04     107     120 ..      26      39 ..      11      42 .. 0.58
   2 ?   10.9   0.0     8e-05      0.36      62     105 ..     420     463 ..     371     469 .. 0.88
   3 ?    0.2   0.1      0.16   7.1e+02      44      65 ..     816     837 ..     776     842 .. 0.63

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.4
    LOH1CR12 107 vpllEtlnelLded 120
                    lE++ne L++d
  EFC38831.1  26 CSCLEKVNETLKKD 39 
                 45667777777665 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 8e-05
    LOH1CR12  62 dakiitllaelrekqkqyasyaealskvnelsdqlsriqiiled 105
                   +i   +++  e +k++++y + lsk nel+ +ls+i   +++
  EFC38831.1 420 TSQILYFFTKWTESEKTFNNYKQILSKYNELHGDLSKIFRAMNQ 463
                 556788899999**************************988887 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.16
    LOH1CR12  44 AkavAadqaklverikevdaki 65 
                  k+   +q++l e+ik ++++i
  EFC38831.1 816 NKKLNENQKALEEKIKILEEEI 837
                 2334444555555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (845 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1871  (0.104356); expected 358.6 (0.02)
Passed bias filter:                      531  (0.0296168); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.81u 0.31s 00:00:01.12 Elapsed: 00:00:00.51
# Mc/sec: 4967.37
//
Query:       EFC38832.1  [L=665]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-75  253.3   1.1    3.5e-75  251.8   1.1    1.9  1  RIO1             RIO1 family
     0.0022   18.0   0.0      0.033   14.1   0.0    2.4  3  APH              Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.043   13.9   0.1        6.5    6.9   0.1    3.4  4  Peptidase_M24_C  C-terminal region of peptidase_M24
       0.36    9.5   7.0      0.027   13.3   1.2    2.3  2  Pkinase_fungal   Fungal protein kinase


Domain annotation for each model (and alignments):
>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  251.8   1.1   7.8e-79   3.5e-75       1     186 [.     237     429 ..     237     431 .. 0.95

  Alignments for each domain:
  == domain 1  score: 251.8 bits;  conditional E-value: 7.8e-79
                 EEEEEEETTTE.....EEEEEEE-S---SS-HHHHCTTTSTTSTCG--GS-HHHHHHHHHHHHHHHHHHHHHTT--S--EEEEETTEEEEE--EETTEE CS
        RIO1   1 nVyhavsedgk.....evaiKiyktstteFkkrkkyvsgekrfkdrksktnprklvklwaekEfrnLkrleeagvpvPkpielkrhvlvmefigedgva 94 
                 nVy a+  +++     ++a+Kiykts+++Fk+r++yv+ge+rfk+ +sk+nprk+v++waekE+rnL+rle+ g+p+P++  lk+hvlvm+fig++g++
  EFC38832.1 237 NVYIAYGDKEEensekQYAVKIYKTSILVFKDRDRYVTGEYRFKSGYSKHNPRKMVRVWAEKEMRNLRRLENVGIPCPSVHVLKQHVLVMSFIGKNGWP 335
                 7999998444455677*********************************************************************************** PP

                 GGBHHHCG.-HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETTEEEE--GTTEEETTSTTHHHHHHHHHHHHHHHHHTTC--.---HH CS
        RIO1  95 apklkdve.eeeeaeelyeevleemrklykeaglvHaDLSeyNvlvdedkvviIDvsQaveldhpnalefLerDveniikfFrrkgve.kvdee 186
                 ap+lkd++ +e++ +e+y +++++mr +y++a+lvH+DLSeyN+l+ +++v+iIDvsQ+ve dhpnalefL++D+eni +fF ++g + +++++
  EFC38832.1 336 APRLKDAKlTESKYREIYLDIIKSMRTMYQKAKLVHGDLSEYNMLYFKGRVYIIDVSQSVENDHPNALEFLRKDCENIKNFFYKNGLTnIMTTR 429
                 ********77***************************************************************************998666666 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       2.5   1.1e+04     165     177 ..     110     122 ..     107     128 .. 0.77
   2 ?    1.9   0.0     0.041   1.8e+02      37      59 ..     296     318 ..     247     330 .. 0.79
   3 !   14.1   0.0   7.4e-06     0.033     113     192 ..     313     390 ..     300     395 .. 0.64

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 2.5
                 -EEEE-SS-SGGG CS
         APH 165 ptvllHgDlhpgN 177
                 +t l+H+Dl + N
  EFC38832.1 110 STDLVHRDLLTEN 122
                 66799***87766 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.041
                 HHHHHHHHHHHHHTT-B--B-CT CS
         APH  37 irrevallrlLakagvpvPevla 59 
                 +++e + lr L++ g+p+P v+ 
  EFC38832.1 296 AEKEMRNLRRLENVGIPCPSVHV 318
                 68999***************987 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 7.4e-06
                 TTB-SHHCHTCCHHHHHHCHHHCCCGCCTCCHHHHHHHH.HHHHHHHH--S....SS-EEEE-SS-SGGGEEEC..TTEEEEE-- CS
         APH 113 lpladflaqdlellrqlesatarllaselldlleeleeq.vlaalaallpg....elptvllHgDlhpgNllvdpddgrvtGviD 192
                 +p  + l+q + +  ++ +   +++a++l+d  ++l+e   ++  ++   +     +++ l+HgDl+  N+l    +grv ++iD
  EFC38832.1 313 CPSVHVLKQHVLVMSFIGKN--GWPAPRLKD--AKLTESkYREIYLDIIKSmrtmYQKAKLVHGDLSEYNMLYF--KGRV-YIID 390
                 55555555555555555555..677777777..444444333333333333444588899**************..***9.**** PP

>> Peptidase_M24_C  C-terminal region of peptidase_M24
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.04   1.8e+02      10      27 ..     106     123 ..     102     131 .. 0.88
   2 ?   -1.4   0.0      0.56   2.5e+03      43      63 .]     392     413 ..     388     413 .. 0.74
   3 ?   -3.6   0.0       2.7   1.2e+04      30      45 ..     444     459 ..     443     465 .. 0.81
   4 ?    6.9   0.1    0.0015       6.5      19      46 ..     625     658 ..     622     664 .. 0.70

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.04
                      -----STT--GGGS-HHH CS
  Peptidase_M24_C  10 lvPidrklIdvslLtpeE 27 
                      +vP  ++l+ ++lLt+++
       EFC38832.1 106 IVPSSTDLVHRDLLTENQ 123
                      79*************975 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.56
                      HHHHHHT-.H.HHHHHHHT--- CS
  Peptidase_M24_C  43 splLeeen.eeleWLkraTrpl 63 
                      s+ +e+++ ++le+L++ ++ +
       EFC38832.1 392 SQSVENDHpNALEFLRKDCENI 413
                      666666645569*******976 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 2.7
                      HHHHHHHHHHHHHHHH CS
  Peptidase_M24_C  30 wLnaYhakvreklspl 45 
                       +++Y ++ +ek++++
       EFC38832.1 444 QIDSYLETMMEKIQDR 459
                      6899999999998765 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0015
                      -GGGS-HHH.HHHHHHHHH.....HHHHHHHHHH CS
  Peptidase_M24_C  19 dvslLtpeE.iawLnaYha.....kvreklsplL 46 
                      d s +t+eE ++w+ +Y++     k+ +k++++L
       EFC38832.1 625 DLSAMTKEErKKWVKEYNRerrktKIPKKVKKKL 658
                      678999999678******9444444555555555 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   1.2     6e-06     0.027     307     361 ..     348     396 ..       5     409 .. 0.76
   2 ?   -1.9   0.5      0.24   1.1e+03     228     248 ..     529     564 ..     465     648 .. 0.61

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 6e-06
  Pkinase_fungal 307 ellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlake 361
                     +  e   D Ik  r +++ka+++H D Se+N+l        + +  +iD+   +e
      EFC38832.1 348 KYREIYLDIIKSMRTMYQKAKLVHGDLSEYNMLYF------KGRVYIIDVSQSVE 396
                     4456678************************9987......55556666655555 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.24
  Pkinase_fungal 228 tkaekfrskrkvvsssssqe...............l 248
                     ++a++++ ++++ +s++sq+               +
      EFC38832.1 529 QEAQQLEGQEEANTSTPSQTeassattveppvivaS 564
                     333344444444444444444444443333333221 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2112  (0.117798); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.77u 0.35s 00:00:01.12 Elapsed: 00:00:00.52
# Mc/sec: 3864.92
//
Query:       EFC38833.1  [L=537]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.8e-27   95.9  23.4    4.2e-14   52.8   0.0    2.3  2  TauE           Sulfite exporter TauE/SafE
  ------ inclusion threshold ------
      0.044   13.7   0.3      0.044   13.7   0.3    4.0  4  DUF3487        Protein of unknown function (DUF3487)
        3.1    7.4   8.2         15    5.2   0.3    2.8  2  Baculo_11_kDa  Baculovirus 11 kDa family
        9.5    6.4   9.7        1.5    8.9   0.8    3.3  3  QCR10          Ubiquinol-cytochrome-c reductase complex subun


Domain annotation for each model (and alignments):
>> TauE  Sulfite exporter TauE/SafE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.8   0.0   9.3e-18   4.2e-14       6     114 ..     110     237 ..     105     267 .. 0.80
   2 !   43.1  21.1   8.6e-15   3.9e-11      92     231 ..     355     501 ..     299     512 .. 0.79

  Alignments for each domain:
  == domain 1  score: 52.8 bits;  conditional E-value: 9.3e-18
        TauE   6 llaGfvagllGiGggliavPlLlll..lppavavatsllavvatslsgalahrrrgn.......vdwrlllllllgsliGallGallllllpsellkll 95 
                 +++++++++ G Ggg ++vPlL +l  +++++av++s ++++  +++++++ + r +       +d+ ++l++ +++l+G+++G++l    p+ ++ l 
  EFC38833.1 110 FIGSVLSSAGGTGGGGVFVPLLHVLgrFNAQEAVPLSKVMIFGAAVTNVFTLFFRSHpyadrplIDYDIALMMEPATLLGTIIGVFLNIICPEWVIVLS 208
                 5666****************99995599***************99999999533222234444499*********************999999999999 PP

        TauE  96 fgvlllllallmllrkkr..........s 114
                 + ++l+++ +l++++ ++          +
  EFC38833.1 209 VIIVLTITTILTFRKFFQrarvefaflwK 237
                 99999999999988555444455555551 PP

  == domain 2  score: 43.1 bits;  conditional E-value: 8.6e-15
        TauE  92 lkllfgvlllllallmllrkkr........srak..grerrptaillvligglvGllsGllGiGgGfllvpllllllglplkkavatslllilvislag 180
                   +++g++++++a+++l+  +r           +   ++++ +  + + +++++G+l+++lGiGgG++  pllll lg ++ + +at++++i+++s ++
  EFC38833.1 355 SFPIIGAIMIIVAAYLLIDYRRkvkrghvfV--QgdVKWNWINVTFYPGACLIAGILAAMLGIGGGMIKSPLLLL-LGSDPAVGAATAAFMIFFTSSIS 450
                 46899***********994444345555553..04467888888877777677*******************995.79999**9*************** PP

        TauE 181 algyalagavdwpllllllpgallGallGarlarrlsertlrrlfallllv 231
                  + +a+ g + +++++l+++++++ +++G  +++   er+ +r +++l + 
  EFC38833.1 451 SAQFAIVGRIPFDYGMLYGLTGFVSGFVGYFFVTFGVERWGKRSLIILCVG 501
                 *****************************9999888888877777766553 PP

>> DUF3487  Protein of unknown function (DUF3487)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.3   9.8e-06     0.044      27      76 ..     180     229 ..     166     238 .. 0.91
   2 ?    0.9   0.2     0.091   4.1e+02      32      59 ..     345     371 ..     334     387 .. 0.63
   3 ?   -2.0   1.2      0.72   3.2e+03      28      65 ..     410     447 ..     400     459 .. 0.62
   4 ?   -2.1   3.2      0.77   3.4e+03      32      70 ..     476     514 ..     465     520 .. 0.63

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 9.8e-06
     DUF3487  27 vlaglglvvglvlglllallvgslaliptialllvllvvlvggkllarlK 76 
                 +++  ++++g ++g++l ++   +++++ ++++l + ++l   k+++r +
  EFC38833.1 180 LMMEPATLLGTIIGVFLNIICPEWVIVLSVIIVLTITTILTFRKFFQRAR 229
                 566678899************************************99975 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.091
     DUF3487  32 glvvglvlglllallvgslaliptiall 59 
                 + v + ++gl + +++g++++i+++ ll
  EFC38833.1 345 SPVYWTLVGLSF-PIIGAIMIIVAAYLL 371
                 445666666665.556666666655544 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.72
     DUF3487  28 laglglvvglvlglllallvgslaliptialllvllvv 65 
                 +a+lg+  g++ + ll+ll +  a++ + a ++++++ 
  EFC38833.1 410 AAMLGIGGGMIKSPLLLLLGSDPAVGAATAAFMIFFTS 447
                 45666666666666666666655665555555555444 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 0.77
     DUF3487  32 glvvglvlglllallvgslaliptialllvllvvlvggk 70 
                 g+v ++ +   +  + +  ++i+ ++l+l+++++l+gg 
  EFC38833.1 476 GFVGYFFVTFGVERWGKRSLIILCVGLVLLFATMLMGGV 514
                 444444444444444555577777778888888888775 PP

>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   2.6    0.0069        31      35      73 ..     194     232 ..     189     238 .. 0.81
   2 ?    5.2   0.3    0.0034        15      29      48 ..     306     325 ..     300     328 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.0069
  Baculo_11_kDa  35 dFvLvicglvvfvvivlfilLlvvilknaeaeeaekekr 73 
                     F+ +ic   v+v+ v+ +l + +il+  +  +++++++
     EFC38833.1 194 VFLNIICPEWVIVLSVIIVLTITTILTFRKFFQRARVEF 232
                    69999**99999999999999999999888888777765 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0034
  Baculo_11_kDa  29 NrsflrdFvLvicglvvfvv 48 
                     + + + FvL++c +++f +
     EFC38833.1 306 KTPYWKIFVLIVCWIIIFTL 325
                    5567788**********976 PP

>> QCR10  Ubiquinol-cytochrome-c reductase complex subunit (QCR10)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.1     0.062   2.8e+02      14      33 ..     146     165 ..     134     168 .. 0.65
   2 ?    8.9   0.8   0.00034       1.5      20      47 ..     435     462 ..     432     466 .. 0.94
   3 ?   -0.7   1.1      0.34   1.5e+03       6      31 ..     462     483 ..     457     490 .. 0.53

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.062
       QCR10  14 ptlalfGgaagvavlfftsg 33 
                 ++ ++fG+a      +f+ +
  EFC38833.1 146 SKVMIFGAAVTNVFTLFFRS 165
                 57899999887666666655 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00034
       QCR10  20 GgaagvavlfftsgvPrvqkdiLqkiPv 47 
                 G+a++++ +ffts++   q  i  +iP+
  EFC38833.1 435 GAATAAFMIFFTSSISSAQFAIVGRIPF 462
                 9**********************99997 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.34
       QCR10   6 lktltrygptlalfGgaagvavlfft 31 
                 +     yg+  +l G+++g+   ff+
  EFC38833.1 462 FD----YGMLYGLTGFVSGFVGYFFV 483
                 44....45555555555555555553 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (537 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1461  (0.0814881); expected 358.6 (0.02)
Passed bias filter:                      764  (0.0426125); expected 358.6 (0.02)
Passed Vit filter:                        72  (0.00401584); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.45
# Mc/sec: 3566.86
//
Query:       EFC38834.1  [L=195]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.022   14.7   5.0      0.034   14.1   5.0    1.6  1  PIG-P     PIG-P


Domain annotation for each model (and alignments):
>> PIG-P  PIG-P
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   5.0   1.9e-06     0.034      11      73 ..      46     107 ..      34     181 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.9e-06
       PIG-P  11 llstlafllyllwallPeevlhalgityypnryWalavpayllmlvlyiyvalaslnlevltp 73 
                  ls+l++ +++lw +++ ++l+  g++   +ry +l+   ++++++++++++l +l   +lt 
  EFC38834.1  46 ALSILVVSFFILWIYVSRKFLEWKGMHS-HERYIILTKKLFFVACFFVCLIILKALANIFLTT 107
                 57899999******************76.69************99999999998775546665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (195 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1126  (0.0628033); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1208.96
//
Query:       EFC38835.1  [L=308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.39   10.5  24.3      0.052   13.4   8.2    2.4  2  SURF6         Surfeit locus protein 6
        8.1    6.9  12.5        3.3    8.2   3.6    2.8  3  PBP1_TM       Transmembrane domain of transglycosylase PBP1 a


Domain annotation for each model (and alignments):
>> SURF6  Surfeit locus protein 6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   8.1     0.009        81       9      57 ..      53     100 ..      28     136 .. 0.51
   2 ?   13.4   8.2   5.8e-06     0.052       4     100 ..     147     248 ..     144     265 .. 0.63

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.009
       SURF6   9 kkkeerkekkkeekeeakkeeeekaeekkakeeaeakkskkkkkkkkea 57 
                 kk       +++++++  +++++k++++++++++ea+  ++++++++++
  EFC38835.1  53 KKSTTTSSSQRKRQQQGSSSSQRKDNSDSSSDDEEAS-LSTSNNNNNTS 100
                 2222233333333333333333333333333332222.33333333222 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 5.8e-06
       SURF6   4 leerrkkkeerkekkkeekeeakkeeeekaeekkakeeaeakkskkkkkkkkeas......kkee.....dlvFskldfedgaekkskkkkkkkkkkgp 91 
                   e +k++e+ +++kk++k    +++++++++++  +  ++++ ++ ++k++e s      +  +     ++v  +ld+++++++++k++    k+k+p
  EFC38835.1 147 STESEKEEEQINRRKKQKKTTTVSKSKASSSAASVISVVSDDTPPPHSEKSQEMShsningN--SnrissSFVEPRLDISNTSRNAEKSS----KSKTP 239
                 55666666677777777777777777777777777777777766666666666665556542..14577789999999943322222222....24456 PP

       SURF6  92 tkkdpkqaL 100
                 tk++ k+ L
  EFC38835.1 240 TKSQSKSSL 248
                 665555555 PP

>> PBP1_TM  Transmembrane domain of transglycosylase PBP1 at N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   3.6   0.00036       3.3      18      70 ..      53     105 ..      47     109 .. 0.61
   2 ?    4.4   0.1    0.0053        47      25      64 ..     128     167 ..     120     183 .. 0.62
   3 ?   -4.0   0.3         2   1.8e+04      58      60 ..     235     237 ..     225     247 .. 0.41

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00036
     PBP1_TM  18 akparkkasrrrrrdddyddeyddeedDdddddeeeevprkgkkkkpprkkrr 70 
                 +k++   +s+r+r+++      ++++ D   ddee  ++  +++++++ +++ 
  EFC38835.1  53 KKSTTTSSSQRKRQQQGSSSSQRKDNSDSSSDDEEASLSTSNNNNNTSGNRSN 105
                 33333444444444444455567778888888888888888777777777765 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0053
     PBP1_TM  25 asrrrrrdddyddeyddeedDdddddeeeevprkgkkkkp 64 
                 +srr+r     d ++++e   + +++ee+   rk +kk +
  EFC38835.1 128 SSRRKRAPVVLDSNFSYELSTESEKEEEQINRRKKQKKTT 167
                 5555555556677777777777666666666665333332 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 2
     PBP1_TM  58 kgk 60 
                 k+k
  EFC38835.1 235 KSK 237
                 111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2479  (0.138268); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                       137  (0.00764125); expected 17.9 (0.001)
Passed Fwd filter:                        70  (0.00390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.33u 0.38s 00:00:01.71 Elapsed: 00:00:00.56
# Mc/sec: 1648.55
//
Query:       EFC38836.1  [L=287]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.1e-15   55.0   0.0    6.9e-14   52.1   0.0    2.3  1  Peptidase_C26  Peptidase C26
    8.2e-09   35.5   0.0    1.3e-08   34.9   0.0    1.3  1  GATase         Glutamine amidotransferase class-I


Domain annotation for each model (and alignments):
>> Peptidase_C26  Peptidase C26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.1   0.0   7.7e-18   6.9e-14      18     216 .]       8     208 ..       2     208 .. 0.71

  Alignments for each domain:
  == domain 1  score: 52.1 bits;  conditional E-value: 7.7e-18
  Peptidase_C26  18 qdaeesylaasyveavekagglpvllpieedeedvkaildkldgllltGgqdvePslygeepsekeeeadpeRdalelaLiraalergvPilgiCr 113
                    ++++esylaasyv+ +e  g+++v +p++ ++e+++ + ++l+g++++Gg +         + + +e++ +    ++ a+ ++    ++Pi+g+C+
     EFC38836.1   8 KTYGESYLAASYVKWIESGGARVVPIPYDLPQEKLNLLFNSLNGIVFPGGGT---------SLRYSEYYYTLKFFFDKAIEANNRGDYFPIWGTCL 94 
                    56789*********************************************98.........34455678888999********************* PP

  Peptidase_C26 114 GlqllnvalGGt...lyqdieeqsgltdhreheqsaashavkvekgsl.laell.....g.seeievnslHhqaike........laeelrveAva 191
                    G++ lnv    +   l+   ++         ++ s + h v+  k+s  + ++      + +e+  + + H  +i+         l++ +++ +v 
     EFC38836.1  95 GFEALNVLAADNpdvLHFGFDS---------ENLSLNLHFVNDYKNSRiFGKAPlsvmqIlAEQNVTMNNHMAGITPetfmkndrLNQFYKMLSVN 181
                    ******9765431113333332.........22233333333222222022222333322235566667799999888899999977777777766 PP

  Peptidase_C26 192 eD..gviEaieseeakafvlgvQwHPE 216
                    +D  g +   ++e+ k++++g Q+HPE
     EFC38836.1 182 ADrkGQVFVSTIESLKYPIYGTQFHPE 208
                    64226666666666779*********9 PP

>> GATase  Glutamine amidotransferase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   0.0   1.4e-12   1.3e-08      23     175 ..      29     211 ..      11     223 .. 0.70

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 1.4e-12
                 EEEEEETTSHHHHHHH.THHSTSEEEEEEESSCTT.....TTTHHHHHHHHCT.........STS-EEEETHHHHHHHHHTTT...EEE.......... CS
      GATase  23 kvevvpidasaeeile.llknpdgilvsgGpgspg.....vegkieaikeare.........nkiPiLGICLGmQllaiefgr...kvv.......... 93 
                 +v  +p+d ++e+  + l ++ +gi+++gG  s       +     ++k++++            Pi G CLG+ +l    +                 
  EFC38836.1  29 RVVPIPYDLPQEKL-NlLFNSLNGIVFPGGGTSLRyseyyY-----TLKFFFDkaieannrgDYFPIWGTCLGFEALNVLAADnpdV-Lhfgfdsenls 120
                 44445555554444.44588999*****9999988555552.....3333333233334333679************9999996640.25555555555 PP

                 .EEECEEEEEEEEEEEETTT.CGGTTTTSEEEEEEEEEEEEESG.....CHHHTTEEEEEEEETTE...EEEEEEEETTTEEEESSBTTSTT CS
      GATase  94 .kekekehhggtmrlgddet.allyglknevierhrHryevnpk.....elepaglevtaksedde...elmeiiekknpfvgvQFHPEsts 175
                  + + + +  +++r+  +   ++++ l ++  ++ +H   ++p+     + +++  +++ +++d +    +  i  +k+p++g+QFHPE+++
  EFC38836.1 121 lNLH-FVNDYKNSRIFGKAPlSVMQILAEQNVTMNNHMAGITPEtfmknDRLNQFYKMLSVNADRKgqvFVSTIESLKYPIYGTQFHPEKIQ 211
                 5555.999999999988555899999999999***********998888555665666666666555535555666666**********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (287 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       498  (0.0277762); expected 358.6 (0.02)
Passed bias filter:                      269  (0.0150036); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.42u 0.27s 00:00:00.69 Elapsed: 00:00:00.41
# Mc/sec: 2085.57
//
Query:       EFC38837.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-09   37.7   7.3    9.5e-05   22.2   0.1    5.5  6  LRR_6     Leucine Rich repeat
    3.5e-08   33.6  17.9      0.077   13.5   0.6    4.9  4  LRR_4     Leucine Rich repeats (2 copies)
     0.0032   17.2  16.8       0.41   10.5   3.5    5.1  4  LRR_8     Leucine rich repeat
     0.0099   16.3   6.8        4.7    8.2   0.0    4.9  3  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.6   0.1    0.0092        41       5      21 ..     153     169 ..     151     172 .. 0.88
   2 ?   -1.1   0.0      0.59   2.7e+03      12      24 .]     189     201 ..     188     201 .. 0.87
   3 !   22.2   0.1   2.1e-08   9.5e-05       3      21 ..     206     224 ..     204     226 .. 0.90
   4 !    9.1   0.2   0.00033       1.5       3      19 ..     233     249 ..     232     254 .. 0.90
   5 ?    0.7   0.0      0.17   7.5e+02       3      15 ..     259     271 ..     259     272 .. 0.85
   6 ?   -1.6   0.1       0.9     4e+03       3      16 ..     289     302 ..     287     302 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0092
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 L+ LdLs+ ++g  G++
  EFC38837.1 153 LQVLDLSYSKLGSLGIS 169
                 899*********98875 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.59
       LRR_6  12 gNdIgDeGaeaLa 24 
                 +N ++ +G+e L+
  EFC38837.1 189 YNVLTHKGLEVLC 201
                 799999****998 PP

  == domain 3  score: 22.2 bits;  conditional E-value: 2.1e-08
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 t+L+eLdLs+N IgD G++
  EFC38837.1 206 TKLKELDLSFNRIGDTGCT 224
                 89***************87 PP

  == domain 4  score: 9.1 bits;  conditional E-value: 0.00033
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                 ++Lt+L+L +N Ig++G
  EFC38837.1 233 NSLTSLELYDNRIGNQG 249
                 69*************99 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.17
       LRR_6   3 thLteLdLsgNdI 15 
                 ++L+  +L++N +
  EFC38837.1 259 QSLRFINLRFNAV 271
                 58999******76 PP

  == domain 6  score: -1.6 bits;  conditional E-value: 0.9
       LRR_6   3 thLteLdLsgNdIg 16 
                 +++++ +L +N+I+
  EFC38837.1 289 PNIQSINLLFNKID 302
                 68899999999995 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.1   0.00055       2.5      14      39 ..     144     166 ..     134     173 .. 0.75
   2 !   10.9   1.6   0.00011      0.48      18      38 ..     202     220 ..     151     228 .. 0.83
   3 !   13.5   0.6   1.7e-05     0.077       2      39 ..     234     274 ..     233     281 .. 0.85
   4 !    8.7   1.5   0.00052       2.3      19      42 ..     285     306 ..     276     311 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00055
                 -E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4  14 tdiplleklpnLkeLdLsgNnlitdl 39 
                 + ip  + ++ L++LdLs   ++++l
  EFC38837.1 144 S-IPIVN-FTALQVLDLSYS-KLGSL 166
                 4.66666.9********877.77776 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00011
                 -HHH-TT--EEE-.-S----- CS
       LRR_4  18 lleklpnLkeLdLsgNnlitd 38 
                 +l  l++LkeLdLs+N +i+d
  EFC38837.1 202 SLP-LTKLKELDLSFN-RIGD 220
                 455.888999999777.7766 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 1.7e-05
                 S--EEE--SS---E-S-HH....H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplle....klpnLkeLdLsgNnlitdl 39 
                 +L++L L +N++   ++l     ++ +L+ ++L ++n ++ +
  EFC38837.1 234 SLTSLELYDNRIGNQGFLTlvdtNFQSLRFINL-RFNAVDHI 274
                 79***********99997777989*********.65566555 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.00052
                 HHH-TT--EEE-.-S-----GGGG CS
       LRR_4  19 leklpnLkeLdLsgNnlitdldeL 42 
                  +klpn ++++L +N +i d++e+
  EFC38837.1 285 SNKLPNIQSINLLFN-KI-DISEI 306
                 447*********999.99.88776 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.1    0.0029        13      23      40 ..     149     166 ..     146     170 .. 0.82
   2 !   10.5   3.5     9e-05      0.41       3      61 .]     153     218 ..     153     218 .. 0.76
   3 !    8.7   2.9   0.00031       1.4       2      38 ..     207     246 ..     206     271 .. 0.67
   4 ?    3.7   1.7     0.012        54       2      38 ..     260     302 ..     259     311 .. 0.64

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0029
                 T-TT--EEE--SS---GG CS
       LRR_8  23 glsnLkvLdLsnNllttl 40 
                 ++++L+vLdLs+ +l +l
  EFC38837.1 149 NFTALQVLDLSYSKLGSL 166
                 567899999999998776 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 9e-05
                 -SEEE-TTS--SEE.....-TTSSTT-TT--EEE--SS---GGGGGGGTT--..S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltsl.....ddeaFkglsnLkvLdLsnNllttlspgafsgLp..sLrsLdLsgNrL 61 
                 L++LdLs ++l sl     ++   ++l++L+ +  ++N lt+   +++ +Lp  +L++LdLs Nr+
  EFC38837.1 153 LQVLDLSYSKLGSLgisilSQNNANQLRGLRKFTYRYNVLTHKGLEVLCSLPltKLKELDLSFNRI 218
                 6777777777777511111566778899**************8888877654339*********97 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00031
                 T-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllt 38 
                 +L++LdLs+Nr+ + + ++ ++   l++L++L+L +N++ 
  EFC38837.1 207 KLKELDLSFNRIGDTGCTVLRKapfLNSLTSLELYDNRIG 246
                 799*********7766666555444689********9885 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.012
                 T-SEEE-TTS--SEE-TTSST......T-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFk......glsnLkvLdLsnNllt 38 
                 +L+ ++L++N   ++d e+F+      +l+n ++++L  N+++
  EFC38837.1 260 SLRFINLRFNAVDHIDCEVFNseklsnKLPNIQSINLLFNKID 302
                 5666777777777777777743333224777777777777765 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.1    0.0095        43       2      19 ..     153     170 ..     152     176 .. 0.82
   2 !    8.2   0.0     0.001       4.7       1      13 [.     207     219 ..     207     232 .. 0.84
   3 ?    1.2   1.8      0.21   9.3e+02       2      16 ..     235     254 ..     234     306 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0095
       LRR_1   2 LrhLdLsnnpllglppns 19 
                 L++LdLs+  l++l+++ 
  EFC38837.1 153 LQVLDLSYSKLGSLGISI 170
                 9*********98777655 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.001
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++LdLs n+++
  EFC38837.1 207 KLKELDLSFNRIG 219
                 7*********984 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.21
       LRR_1   2 LrhLdLsnnpl.....lglp 16 
                 L++L L +n++     l l 
  EFC38837.1 235 LTSLELYDNRIgnqgfLTLV 254
                 77777777665333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       716  (0.0399353); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2070.85
//
Query:       EFC38838.1  [L=252]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.12   12.4   3.7        0.2   11.6   3.5    1.5  1  Pyrid_oxidase_2  Pyridoxamine 5'-phosphate oxidase


Domain annotation for each model (and alignments):
>> Pyrid_oxidase_2  Pyridoxamine 5'-phosphate oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   3.5   1.1e-05       0.2      38     103 ..      63     128 ..      52     149 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.1e-05
                      EEEE-BSSSTT---S--EEEE-TTSHHHHHHHH--EEEEEEEGGGSSHHHHHT--TTSTT.S-EEEE CS
  Pyrid_oxidase_2  38 nvvsisdgaaddstGnpylllvdidstaqniqknsklsltiseeqtptckkkkvdpespt.carvsl 103
                        +s +++  ++++G+p+++ v  +++ qn  + s +sl+ s++ + ++++k++d ++ + +a+ +l
       EFC38838.1  63 HNSSTKQYISNNNKGSPLMMHVSTSMSKQNR-RASVCSLSASVTSNSSTSDKSTDSSNSSkSAKQTL 128
                      45566667778*******************9.88899999999999999999888877643666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (252 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1778  (0.0991689); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1536.79
//
Query:       EFC38839.1  [L=411]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.5e-47  158.7   3.2    2.8e-18   65.6   0.0    3.2  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.6   0.0   1.6e-22   2.8e-18       4      95 ..     106     211 ..     103     213 .. 0.85
   2 !   48.4   0.1   3.6e-17   6.4e-13      14      92 ..     229     309 ..     222     313 .. 0.89
   3 !   44.0   0.1   8.5e-16   1.5e-11      18      95 ..     332     410 ..     325     411 .] 0.89

  Alignments for each domain:
  == domain 1  score: 65.6 bits;  conditional E-value: 1.6e-22
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH...................CCCSSTTTSCSS.....HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHH CS
   Mito_carr   4 svlkellaGglagavatlvttPldvvKtrlqt...................qkksskksksaa.....ildvlkkiykeeGlrglyrGllpnllrvapa 78 
                  ++++ laG+++g++++++t+Pld +Ktr+q+                   q          +      + +l++iy++eG ++lyrGl p+ll + ++
  EFC38839.1 106 DTVQYGLAGVISGLCTATATQPLDCAKTRIQVfkrlnmelpttsctsqgvyQ----------KimnskSIAMLSSIYRNEGWKALYRGLPPSLLSSCVS 194
                 678899**************************99999998887777533222..........123333888**************************** PP

                 HHHHHHHHHHHHHHHCT CS
   Mito_carr  79 salkfvlyetlkrlllk 95 
                  ++ f +ye +++ + +
  EFC38839.1 195 MSIFFPIYEICRKRFSE 211
                 ************99876 PP

  == domain 2  score: 48.4 bits;  conditional E-value: 3.6e-17
                 HHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS...HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr  14 lagavatlvttPldvvKtrlqtqkksskksksaa...ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrl 92 
                  a a++++++ P+ +vK+rlqt+++ s +s+s++   +l+v+k+iyk+eGl+g+y G+    +  +    l+f++ye lk +
  EFC38839.1 229 SAWAFSSVLVSPISLVKVRLQTSSTISLYSESNPsttFLQVIKSIYKNEGLSGFYAGYRGVAISAT-VFCLYFSIYEPLKLY 309
                 57789***********************999999999********************987666655.7999*****988865 PP

  == domain 3  score: 44.0 bits;  conditional E-value: 8.5e-16
                 HHHHHHHHHHHHHHHHHHCCCSSTTT.SCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHCT CS
   Mito_carr  18 vatlvttPldvvKtrlqtqkksskks.ksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlllk 95 
                 + +++t+P d++   lq q+k+s+   ++++ +d++k+iyk+ G+r+ly+Gl+  llr    + ++ ++yet+ rl+ k
  EFC38839.1 332 AVSTLTYPNDLIISNLQFQGKKSAGGvHYNGWVDAFKSIYKSGGVRALYSGLNTYLLRFCLGTIVTQTSYETILRLMDK 410
                 56799**************999765415555*******************************************99865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (411 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       824  (0.0459591); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2565.61
//
Query:       EFC38840.1  [L=368]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.9e-37  126.8   1.5    1.3e-27   95.8   0.0    2.3  2  Thioredoxin    Thioredoxin
    1.8e-08   34.5   2.4    1.8e-08   34.5   2.4    1.7  2  Thioredoxin_6  Thioredoxin-like domain
    2.4e-08   33.7   4.2     0.0022   17.4   2.5    2.4  2  OST3_OST6      OST3 / OST6 family, transporter family
    2.6e-08   34.3   1.4    2.8e-07   31.0   0.0    2.6  2  Thioredoxin_2  Thioredoxin-like domain
    0.00084   19.6   0.5       0.18   12.1   0.0    3.4  3  Thioredoxin_8  Thioredoxin-like
  ------ inclusion threshold ------
      0.071   13.3   1.4       0.63   10.3   0.5    2.9  2  Glutaredoxin   Glutaredoxin
       0.13   12.5   0.7       0.36   11.1   0.0    2.0  2  Thioredoxin_7  Thioredoxin-like


Domain annotation for each model (and alignments):
>> Thioredoxin  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.8   0.0   5.1e-31   1.3e-27       2     102 ..      30     138 ..      29     139 .. 0.96
   2 !   29.5   0.9   2.2e-10   5.7e-07       3     102 ..     151     255 ..     149     256 .. 0.90

  Alignments for each domain:
  == domain 1  score: 95.8 bits;  conditional E-value: 5.1e-31
                  EEESSHHHHHHHHTT.TSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTT.......TSEEEEEETTTSHHHHHHTT-SSSSEEEEEETTEEEEEEESS CS
  Thioredoxin   2 vlvltkenFeeevak.ekklvlveFyApwCghCkalaPeleklaeelkd.......kvklakvdvdenedlakkyevegiPtlklfkngkevkkyega 91 
                  vl+l+++nFe+++++ ++k ++++F+ApwCghCk+la+++ +la+el+d       +v+lakv++de++d+ +ky+++g+Ptl+lf  gk v +y g 
   EFC38840.1  30 VLELNTQNFETTIQSnPQKVFFIKFFAPWCGHCKRLAGTWSELAKELEDssvphfqNVQLAKVNCDEHPDIRRKYSIRGYPTLVLFVGGKPVTEYYGY 127
                  7899**********97889999**************************************************************************** PP

                  -HHHHHHHHHH CS
  Thioredoxin  92 rekeklaaflk 102
                  r+  k+++fl+
   EFC38840.1 128 RTVPKFKSFLD 138
                  **999999986 PP

  == domain 2  score: 29.5 bits;  conditional E-value: 2.2e-10
                  EESSHHHHHHHHTTTSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTT.TSEEEEEETTTSHHHHHH...TT-SSSSEEEEEETTE.EEEEEESS-HHH CS
  Thioredoxin   3 lvltkenFeeevakekklvlveFyApwCghCkalaPeleklaeelkd.kvklakvdvdenedlakk...yevegiPtlklfkngk.evkkyegareke 95 
                   ++t+ + e++++++++ + v Fy +  ++ k++ + +++la++ kd +  +ak+d++++++l++k   ++ ++ P++++f  ++  +++++++ + e
   EFC38840.1 151 DQVTEVELESKIKNQNRAWTVMFYNSESAQTKQFDSNFQQLATNNKDtNNFFAKIDCNQEKELCTKrltIDLTNGPQFVIFTGSDkMMSQFKEQPSVE 248
                  578888999**************************************9999*************87444678899******99997889999999999 PP

                  HHHHHHH CS
  Thioredoxin  96 klaaflk 102
                  +l++f++
   EFC38840.1 249 SLQKFIT 255
                  **99996 PP

>> Thioredoxin_6  Thioredoxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.29   7.3e+02     118     126 ..      70      78 ..      23     139 .. 0.44
   2 !   34.5   2.4   6.9e-12   1.8e-08      32     183 ..      99     255 ..      85     256 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.29
                    HHHHHHTTT CS
  Thioredoxin_6 118 ekvakefkd 126
                    +++ake++d
     EFC38840.1  70 SELAKELED 78 
                    444444433 PP

  == domain 2  score: 34.5 bits;  conditional E-value: 6.9e-12
                    HHHHHTT--S.SEEEEEETTTTEEEEEETHT--HHHHHHHHHH.....H---SEEE-SHHHHHHHHTSS--EEEEEEE-TTSTTHHHHHHHHHHHH CS
  Thioredoxin_6  32 evadklgvke.pavllfrkfdeekvkydgekitvddlkkfiek.....nslplvreltpenaeelfeeglppllllflkkddeeteklkkaiekva 121
                    ++  k+ +++ p+++lf +  +  ++y+g   tv + k+f+++     +s + v ++t+  +e  ++++ ++  + f+++++  t+++ + ++++a
     EFC38840.1  99 DIRRKYSIRGyPTLVLFVG-GKPVTEYYGY-RTVPKFKSFLDDvfssaKSSGSVDQVTEVELESKIKNQNRAWTVMFYNSESAQTKQFDSNFQQLA 192
                    5667888888899999999.5555777776.6899999988765555588999*****99999999999999************************ PP

                    HHTTTT-E.EEEEETTGGHHHHH.HTT--GGG-SEEEEEESSSS-EEEETTSS--HHHHHHHHH CS
  Thioredoxin_6 122 kefkdkin.faladaksfkrple.ylglsssdlPvivivdsashkykyppkdefspeklkeFlk 183
                    ++ kd  n fa +d+ + k+++  +l ++ + +P++vi+  ++++    +k+++s+e+l++F++
     EFC38840.1 193 TNNKDTNNfFAKIDCNQEKELCTkRLTIDLTNGPQFVIFTGSDKMMSQ-FKEQPSVESLQKFIT 255
                    ****9877688*********9888***************977777544.5999*********97 PP

>> OST3_OST6  OST3 / OST6 family, transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   1.9e-06    0.0047      10     109 ..      26     121 ..      17     174 .. 0.80
   2 !   17.4   2.5   8.6e-07    0.0022      36     156 ..     173     278 ..     138     300 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.9e-06
   OST3_OST6  10 s.ngviklndenykellk.gprdysvvvllTatspqfkCelCrefepefelvakswrkdekskskklfFakvdfdegkdvFqklglnsaPhlllfppkk 106
                 s + v++ln++n+++ ++ +p+   ++ ++        C  C+ ++  ++ +ak    ++  + +++  akv+ de +d+ +k+ ++  P l+lf   +
  EFC38840.1  26 SsGVVLELNTQNFETTIQsNPQKVFFIKFFAPW-----CGHCKRLAGTWSELAKELEDSSVPHFQNVQLAKVNCDEHPDIRRKYSIRGYPTLVLFVG-G 118
                 336788999999999998788888888888654.....*********************77899*******************************88.3 PP

   OST3_OST6 107 gpk 109
                 +p 
  EFC38840.1 119 KPV 121
                 333 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 8.6e-07
   OST3_OST6  36 llTatspqfkCelCrefepefelvakswrkdekskskklfFakvdfdegkdvFqk...lglnsaPhlllfppkkgpkeskkkdtydfsrggfdaealak 131
                 +  ++s     +  ++f+++f+++a   + +      + fFak+d ++ k++  k   + l++ P++++f  ++        + +   +++ ++e+l k
  EFC38840.1 173 FYNSES-----AQTKQFDSNFQQLATNNKDT------NNFFAKIDCNQEKELCTKrltIDLTNGPQFVIFTGSD--------KMMSQFKEQPSVESLQK 252
                 334443.....44589999999999765555......89*************9999999***********9933........23333344668999999 PP

   OST3_OST6 132 fise.rtgvkirikrppnyskiiita 156
                 fi++ ++  k++i  p++ + +i+ +
  EFC38840.1 253 FITSgHVSSKVQIPGPVDNTPTILHF 278
                 99773555999999998888887766 PP

>> Thioredoxin_2  Thioredoxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.0   1.1e-10   2.8e-07       5     107 ..      47     135 ..      42     137 .. 0.86
   2 ?    1.4   0.4      0.16   4.2e+02      42      86 ..     230     278 ..     162     287 .. 0.40

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 1.1e-10
  Thioredoxin_2   5 gkpvlvvftdpdCpyCkklkkelkelddvtvrvllfplkpsfepkavaiwcakekkkafkdieenvelarkygvrgtPtivfldgkeivarlpGyv 100
                    +k +++ f +p+C+ Ck+l  + +el    +      l++s++p++++++ ak         +e+ +  rky +rg Pt+v++ g ++v+++ Gy 
     EFC38840.1  47 QKVFFIKFFAPWCGHCKRLAGTWSEL---AKE-----LEDSSVPHFQNVQLAKVN------CDEHPDIRRKYSIRGYPTLVLFVGGKPVTEYYGYR 128
                    577788899**********9977777...777.....9999************87......69****************9966666699******8 PP

  Thioredoxin_2 101 paeelea 107
                    +  +++ 
     EFC38840.1 129 TVPKFKS 135
                    8777765 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.16
  Thioredoxin_2  42 lkpsfepkavaiwcakekkkafkd....ieenvelarky....gvrgtPtiv.f 86 
                    +   +++ + +++ ++++ +++++       +v     +    +v+ tPti+ f
     EFC38840.1 230 IFTGSDKMMSQFKEQPSV-ESLQKfitsG--HVSSK--VqipgPVDNTPTILhF 278
                    222222333333333332.2333333211..11111..1224467777776645 PP

>> Thioredoxin_8  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   7.1e-05      0.18       2      45 ..      48      96 ..      47     104 .. 0.83
   2 ?    2.3   0.0     0.083   2.1e+02      70      89 ..      96     115 ..      83     119 .. 0.79
   3 ?    2.4   0.1     0.076     2e+02       6      29 ..     171     194 ..     144     237 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.1e-05
                   SEEEEEE--SSSHHHHHHHHHHHHHHHHHHH.....TTSEEEEEEE-SS CS
  Thioredoxin_8  2 kvvlLyfgaswcppckaftpklkelyeklkk.....kkkveivyvsldk 45
                   kv+++ f+a wc +ck+   + +el ++l++      ++v++  v++d+
     EFC38840.1 48 KVFFIKFFAPWCGHCKRLAGTWSELAKELEDssvphFQNVQLAKVNCDE 96
                   8999********************9999995555557888888888886 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.083
                    -HHHHTT-S--TT-SEEEEE CS
  Thioredoxin_8  70 krnklkkkynvkaiPtlvvl 89 
                    ++  +++ky + ++Ptlv+ 
     EFC38840.1  96 EHPDIRRKYSIRGYPTLVLF 115
                    4557899**********985 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.076
                    EEE--SSSHHHHHHHHHHHHHHHH CS
  Thioredoxin_8   6 Lyfgaswcppckaftpklkelyek 29 
                    ++f++s++++ k+f ++ ++l ++
     EFC38840.1 171 VMFYNSESAQTKQFDSNFQQLATN 194
                    344444444444444444444444 PP

>> Glutaredoxin  Glutaredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.5   0.00025      0.63       4      58 ..      51     119 ..      49     133 .. 0.75
   2 ?   -3.5   0.0         5   1.3e+04      30      51 ..     335     355 ..     333     355 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00025
                   EES...TSSHHHHHHHHHHHHTT.............GGEEEEEGCCSHHHHHHHHHHHTSSSSSEEEETTE CS
  Glutaredoxin   4 ftk...ptCpyCkkakrlLkelg.............vkfeeidvdkdeeireelkelsgvrtvPqvfidgk 58 
                   f k   p+C++Ck+   +  el              v+ + ++ d++++ir +   + g++t+ ++f++gk
    EFC38840.1  51 FIKffaPWCGHCKRLAGTWSELAkeledssvphfqnVQLAKVNCDEHPDIRRKYSIR-GYPTL-VLFVGGK 119
                   6677779*******9988755554444666666666889999999*99999999555.76766.6667776 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 5
                   EGCCSHHHHHHHHHHHTSSSSS CS
  Glutaredoxin  30 dvdkdeeireelkelsgvrtvP 51 
                   dv+ de + +++ e +  +t P
    EFC38840.1 335 DVSSDE-EGDKVVEATSNETAP 355
                   888885.444444555547766 PP

>> Thioredoxin_7  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00014      0.36      18      81 ..      48     115 ..      43     116 .. 0.79
   2 ?   -1.9   0.1       1.5   3.9e+03      15      45 ..     164     194 ..     159     211 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00014
                    --EEEEE--TT-HHHHHH.HHHHHH-HHHHH.HHHT-EEEEESS--S-GGG.-TT-....--SSEEEEE CS
  Thioredoxin_7  18 kpvlvffgaswcftCqal.erdflsdeevkaalaekfvllrvdvterdanilelde....qgvPvvafl 81 
                    k  ++ f a wc++C++l  ++ + ++e+      +f  +++   + d++  ++++    +g+P+++++
     EFC38840.1  48 KVFFIKFFAPWCGHCKRLaGTWSELAKELEDSSVPHFQNVQLAKVNCDEHP-DIRRkysiRGYPTLVLF 115
                    55689999**********667788889999967799999999999999999.44452335669999886 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.5
                    HHT--EEEEE--TT-HHHHHHHHHHHH-HHH CS
  Thioredoxin_7  15 ergkpvlvffgaswcftCqalerdflsdeev 45 
                     +++   v+f  s++ + + ++ +f +  ++
     EFC38840.1 164 NQNRAWTVMFYNSESAQTKQFDSNFQQLATN 194
                    5556666777777777777777777665444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (368 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1214  (0.0677115); expected 358.6 (0.02)
Passed bias filter:                      638  (0.0355848); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 2243.66
//
Query:       EFC38841.1  [L=571]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-44  153.1  27.9    3.2e-44  151.6  27.9    1.6  1  Voltage_CLC  Voltage gated chloride channel


Domain annotation for each model (and alignments):
>> Voltage_CLC  Voltage gated chloride channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  151.6  27.9   1.8e-48   3.2e-44       5     353 ..       2     401 ..       1     405 [. 0.79

  Alignments for each domain:
  == domain 1  score: 151.6 bits;  conditional E-value: 1.8e-48
                  HHHHCCCCC-GGGSC-SHHHHHHHCTTSS--...-HHHHHHHHHHHHHHHHCTT-S-BTHHHHHHHHHHHHHHHHHH...TT.--SHHHHH.HHHHHH CS
  Voltage_CLC   5 lagllvklvapeaagsGipevkaalngvkgp...lslrvllvkflasvltvgsGlslGreGplvqiGAavgsglsrl...lklsrndrdrr.lvaaGa 95 
                  +a +l+ lvap a+gsG   +ka+lngv+g    ls+++++vk l++  ++ +Gl +G+ Gp+++i +++++ l ++    ++++ ++ ++ ++++G+
   EFC38841.1   2 FALVLTALVAPSAEGSGLAGIKAILNGVRGLkdvLSMKTMIVKYLSLPAVLTAGLYIGKMGPSIHIVTCAAKNLLKFrlfESIRKTKTLKQeMIVCGI 99 
                  788999************************999******************************************66666444555556777****** PP

                  HHHHHHHHT-HHHHHHHHCTTTSTSS--TTHHHHHHHHHHHHHHHHHHCTTS-S.....-.T..---....--GGGHHHHHHHHHHHHHHHHHHHHHH CS
  Voltage_CLC  96 AAGiAAaFnaPlgGvlfalEevsrefslrallpvfvasvvaalvlrlllgeepa.....fge..veslf.alsllelilfvllGilgGllgalfvrll 185
                  A G AA  +a +gGvlf+ E+v +++slr+++ +f a+++a +++rll +  +      + +  v+ ++ +++l el+++++++i++ ++g++ v+++
   EFC38841.1 100 AVGCAANDGAVVGGVLFGAELVGTYYSLRNYFKSFYAAFIACMTSRLLHSAVNLnikpfL-TwnVKIVPpSFTLPELFFMLFVAIVMSFVGIAVVFVN 196
                  ***********************************************9655544556642.2454444458*************************** PP

                  HHHHH..................HHHCHHCHHHH..HHH.HHHHHHHHHHHHCCCSCC..CSSSSC.CHHHHHCTT-S-...............HHHH CS
  Voltage_CLC 186 lkver..................lfrkleklkik..krl.epalvgllvgllglllpa.svlgggy.eliasllegstl...............llsl 245
                   +++                     +k   l i   +r+ + ++++l++++l+++    ++++ g  + +++ll +++l                  +
   EFC38841.1 197 EQLLVlrdkygklhlgpfkfakyATNK---LVILteNRIiFTIIITLVTSFLSFPQMIgKYMSIGGvPIFEELLMAKPLttvngakgewiqgniSEVF 291
                  999987788888888888644222222...22222355557777777777777776533555544423344444333334455555556666655567 PP

                  HH...HHHHHHHHHHHHHCTT-CSBSHHHHHHHHHHHHHHHHHHHHHH-C....TSSC...HHHHHHCCTHHHHHCCS-HHHHHHHHHHCC--GCCHH CS
  Voltage_CLC 246 lllllllllkllataltlgsgvpgGifaPsLviGAalGrlvglvlalllp....gaassdpgafalvGmaaflagvtrapltaiviviEltgdlelll 339
                  +++ +++ +++++++lt  + v+gG ++ +L+iGA++Grlvg+ la +lp     + +  p+ + lv++aa+ +  t+  +++++i++Eltg + + l
   EFC38841.1 292 ITISIFITVRYILAILTTVLPVSGGSYLQLLIIGASFGRLVGEGLAFILPdgfsPNHPIVPASYGLVAAAALTSSQTQ-AFSSVFILLELTG-HGVHL 387
                  78899*******************************************9998875555578*****************.9************.55555 PP

                  HHHHHHHHHHHHHC CS
  Voltage_CLC 340 plmlavliAkavad 353
                  p + a+ i  ++++
   EFC38841.1 388 PALGASYIGVVISR 401
                  55555555544443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (571 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       582  (0.0324614); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 3743.05
//
Query:       EFC38842.1  [L=225]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       512  (0.0285571); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1602.51
//
Query:       EFC38843.1  [L=1267]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-06   26.8  77.2      0.001   17.7  33.7    5.1  4  Sfi1      Sfi1 spindle body protein


Domain annotation for each model (and alignments):
>> Sfi1  Sfi1 spindle body protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    1.3  11.6    0.0055        98     301     435 ..     368     506 ..     287     564 .. 0.60
   2 !   17.7  33.7   5.7e-08     0.001     128     408 ..     685     980 ..     675     982 .. 0.79
   3 !   14.7  15.8   4.7e-07    0.0084      25     170 ..     961    1115 ..     949    1117 .. 0.76
   4 !    8.6   4.0   3.3e-05       0.6     325     441 ..    1068    1191 ..    1058    1198 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.0055
        Sfi1 301 krevlstlvtntretrtrllqaeeeaeehrkekllrsvlekwreklaeqrereeeAsefyap...rlaqecldawkerlqhvqklekwakdarfyfla. 395
                  +e l+ ++++++ ++++   +  ++e + ++ l++ +l  ++ + + q++r++   +++ +   + a++++ a k+ +++ q l + +++ + y++  
  EFC38843.1 368 AEEKLKMFLNALNANYSNTCYQVTIYEGEISTCLAKLFLIYLKIEKEIQKSRDILLTKLNDEmleNCARNTFYAFKNFTKKQQDLRQQQQRFDNYITHr 466
                 445555566666666666666666666666666666666666666666666666665555441114445666666666666666666555555565442 PP

        Sfi1 396 ..tkaLkkWrkateesrreRrrdayaqvrrkvkinLaskaln 435
                    + + kW++ t+ s  e+ +d +a +   +  nL++ka+n
  EFC38843.1 467 rkVSLFAKWKESTKSSVTEKEKDEVAMIH--YYNNLQRKAFN 506
                 22345666666666666666666666653..44555555555 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 5.7e-08
        Sfi1 128 ekwrderlkrrsllkWlrklrenrereqeaeakrkrlllqkalqiwserseevqaaeaeadsllrqkllrrvleewrkqarlepalrqvsakk..dtrl 224
                 e+++d rlk++++++W++k+ ++   ++ a+++ +   ++k+l  ++e  +++++++ + ++  + +++ +++++wr+ ++l +++++ +a++  + +l
  EFC38843.1 685 EQVYDIRLKKKIFQQWSEKACDKI-LKNRADQFYSDVTKRKVLYVLRENRDDIYEKSLQIQDNSNATMIVKYFNKWRETTELVSHEKDSIASEyyNITL 782
                 799****************99976.56789******************************************************999998887225567 PP

        Sfi1 225 lksalesWkkr..lemsrqarevdrtrllrnaltsWndelrlkalreriderillealykWvleeRlrlfqrireqrlkrevlstlvtntretrtrllq 321
                  ++a++  k    ++   +  ++ ++ l ++  ++ + + +l ++ ++++e+  l++ ++  +  +++l++  re+  kr+ l++ +t   +       
  EFC38843.1 783 ARKAFQALKTTclVDYNPHLNDLCKQWLVKSKERYFK-RWKLMLFLRKSEEKFELAVAEQYQMTLKFKLLTAWREKAKKRQLLRKVLTDGAN-----RM 875
                 89****9998622567778888888888888766654.578899999999999999999999999****99999999999999988765544.....34 PP

        Sfi1 322 aeeeaeehrkekllrsvlekwreklaeqre......reeeAsefyaprlaqecldawkerl...qhvqklekwakdarfyfla.........tkaLkkW 402
                 ++++   ++k+ l++ vl++++++ + + +      + ++ ++fy   l+q+ ++ wk ++   ++ +kle+ +++ +++ +a         +k +k W
  EFC38843.1 876 KAKTTVLENKKSLAKYVLKQLKKNKEVKISrknqyfMFIKSKKFYDDALKQKFFQLWKIKQaigEEQKKLEQSQEEKEKTAIAlnhynqvikKKIIKSW 974
                 4555556666667777777666543333220000114568999**************9887344688899999888888887777788888899***** PP

        Sfi1 403 rkatee 408
                 r+ t e
  EFC38843.1 975 REYTLE 980
                 *99976 PP

  == domain 3  score: 14.7 bits;  conditional E-value: 4.7e-07
        Sfi1   25 ardlylltkafthWaqltseevertsaarrhiLrkkyfnaWreltavnelKaqrfalkkplkkWkartkeie...ereekavqvykqkllkrs.... 114 
                  +++ ++ +k  + W+++t e    t+  +  iL  k+f++Wr ++a++++  ++ + k+++++Wka+ +e +   +++  a+ ++++kl ++s    
  EFC38843.1  961 HYNQVIKKKIIKSWREYTLE----TNFVDIFIL-RKAFENWRIFAAKSTEEPKHKFKKNIFQRWKAALREKNemsSLNSLAERFHERKLAQKSmgsi 1052
                  66667777777777776655....555555555.48*******************************9999877789999********988762222 PP

        Sfi1  115 ....ywkwfwefkerraekwrderlkrrsllkWl...rklrenrereqeaeakrkrlllqkal 170 
                       ++ +++ +  ra+++++e+l+r+ l   l   ++ r++r ++++a+ + ++ l+q+ l
  EFC38843.1 1053 keyiVQQRIEHVQLIRANQYYKESLMRKVLIGLLinvNTIRDKRRKREKADLFYHKKLVQSSL 1115
                  221156777888999**************9999722245556666778888888888888766 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 3.3e-05
        Sfi1  325 eaeehrkekllrsvlekwrekl...aeqrereeeAsefyaprlaqecldawkerlqhvqklekw.....akdarfyf.latkaLkkWrkateesrre 412 
                  +a++ +ke l+r+vl  +  ++   +++r+ +e+A+ fy ++l q++l++  +  + + ++ +      ++  + y+ l+ k ++ W  + ++++ +
  EFC38843.1 1068 RANQYYKESLMRKVLIGLLINVntiRDKRRKREKADLFYHKKLVQSSLESPLSLDRFLNARPNSpfffaKTVNIVYYkLLIKGIDSWTFFVKKEKEK 1164
                  5778899999999999887655111566778899************9987666555555555548888655555555799***************** PP

        Sfi1  413 RrrdayaqvrrkvkinLaskalnaWrska 441 
                  R++ a  +  +    nL++k++n Wr k 
  EFC38843.1 1165 RLMLA--KAVHANASNLVAKCFNLWRIKS 1191
                  *9955..55677788***********886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1267 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2305  (0.128563); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.00u 0.33s 00:00:01.33 Elapsed: 00:00:00.55
# Mc/sec: 6965.31
//
Query:       EFC38844.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.21   10.5  13.7        0.8    8.6  13.0    2.3  1  Radial_spoke  Radial spokehead-like protein
        1.4    9.1   6.0          2    8.6   6.0    1.2  1  YqfQ          YqfQ-like protein


Domain annotation for each model (and alignments):
>> Radial_spoke  Radial spokehead-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  13.0   8.9e-05       0.8     355     451 ..      49     223 ..      39     229 .] 0.78

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 8.9e-05
  Radial_spoke 355 vnpekeeeeeeeeeeeeeeeeeeeeepEtgpplltplseDa........................................................ 395
                   v+p++ ++++e++e++++e+ ++e++     +l+t  +e                                                          
    EFC38844.1  49 VEPKEPKDDDEDNEDKNDEKADDEKKTKPKEELFTITEEKRltwavkmidqdgsvvprgafvvkkddeqvivknqtffgmdkyqasklynfvhlrtp 145
                   45555677777777777666666666666777777666664778889999999*************************9999999999999999999 PP

  Radial_spoke 396 ......................siddvpp...WtvrlssklikkhavavlrSnlWpGAvafaae.kkkfeniYiGwGlkkta 451
                                          +dd +p   W+v++    ++ ++++v rS+lWpG v +    +  ++  YiG+Glk+ +
    EFC38844.1 146 ihktwenivaqqyidksldfadPVDDDIPygcWSVQY----EEIINTVVGRSLLWPGYVFYHKIqTPFYGGFYIGNGLKNVD 223
                   9999988888888888777776444444456687765....55667899********998886534569**********876 PP

>> YqfQ  YqfQ-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   6.0   0.00022         2     104     157 ..      35      88 ..      23     106 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00022
        YqfQ 104 kssedeeteevteseevevseteeseknkkkkpkakkkkkkkkkkdvkeeeiek 157
                 ++s++e t++++ ++e + ++ +++++++k+  ka+++kk k k++ +  + ek
  EFC38844.1  35 EESSEEVTDKQEVPVEPKEPKDDDEDNEDKNDEKADDEKKTKPKEELFTITEEK 88 
                 567888999999999999999999999999999999888888777766554444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1139  (0.0635284); expected 358.6 (0.02)
Passed bias filter:                      620  (0.0345808); expected 358.6 (0.02)
Passed Vit filter:                       103  (0.00574488); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1393.65
//
Query:       EFC38845.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       630  (0.0351386); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1530.36
//
Query:       EFC38846.1  [L=289]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (289 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       447  (0.0249317); expected 358.6 (0.02)
Passed bias filter:                      304  (0.0169558); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1982.94
//
Query:       EFC38847.1  [L=500]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.026   14.6   0.5      0.062   13.3   0.5    1.6  1  DUF489         Protein of unknown function (DUF489)
       0.17   12.1   0.4        1.2    9.4   0.0    2.6  3  Gly_acyl_tr_C  Aralkyl acyl-CoA:amino acid N-acyltransferase,


Domain annotation for each model (and alignments):
>> DUF489  Protein of unknown function (DUF489)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.5   6.9e-06     0.062      78     136 ..      37      93 ..      22      99 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 6.9e-06
                 HHHHHHHHHHHHHHHHSTTHHHHHHHHHHTTHHHHTTS-TTSHHHHHHHHHHHHHHTGG CS
      DUF489  78 tryalsllalerkLsknkealaklgerieqierqlehfdllhenvlanlasiYsdtiSk 136
                  +y+++  +lerkLs ++++ + ++++ie++++   ++    + v++n+ s Y ++i++
  EFC38847.1  37 CKYLME--KLERKLSTKQSLSRLIEKQIEKLQQFNMYMARDRKMVFSNIHSKYLQIIGS 93 
                 555554..79**********************999999******************975 PP

>> Gly_acyl_tr_C  Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.41   3.7e+03      33      61 ..      50      76 ..      34      92 .. 0.62
   2 ?    9.4   0.0   0.00013       1.2      25      64 ..      92     131 ..      85     150 .. 0.83
   3 ?   -2.7   0.1      0.79   7.1e+03      75      87 ..     285     297 ..     265     298 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.41
  Gly_acyl_tr_C 33 rqglvahvivkqakalekkgiPvYshvdk 61
                   ++  ++++i kq+++l++  + +Y+  d+
     EFC38847.1 50 TKQSLSRLIEKQIEKLQQ--FNMYMARDR 76
                   555666677777777765..555665554 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00013
  Gly_acyl_tr_C  25 agtlpkYrrqglvahvivkqakalekkgiPvYshvdkene 64 
                    +  + k r+  lv++v  ++ k+l+  giP++++ dk  +
     EFC38847.1  92 GSEMLKRRNSQLVKQVEESERKCLNVMGIPFFQKLDKWFQ 131
                    56688999*************************9998654 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 0.79
  Gly_acyl_tr_C  75 hveipceWnqWnc 87 
                     + + c+Wn   c
     EFC38847.1 285 LIDFNCKWNASMC 297
                    4567899998777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (500 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1171  (0.0653132); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 3237.36
//
Query:       EFC38848.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.79   10.1  16.5       0.24   11.7   1.0    3.2  3  DUF641    Plant protein of unknown function (DUF641)


Domain annotation for each model (and alignments):
>> DUF641  Plant protein of unknown function (DUF641)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   1.0   1.3e-05      0.24      73     121 ..      83     131 ..      51     135 .. 0.82
   2 ?    4.4   0.4    0.0024        44      85     114 ..     178     207 ..     159     223 .. 0.80
   3 ?    1.9   4.0     0.015   2.7e+02      70     123 ..     223     276 ..     206     280 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.3e-05
      DUF641  73 eseleaeiqeqrsllktyeitvkkleaelkakdseieeLkekLeeaeks 121
                 +++ ++e++++r ++k y++    l+ e+++k+++i+ Lke+ +e++++
  EFC38848.1  83 SENDRREMENLRAIIKEYKAKKLVLDYEISQKENNIKTLKENNTELKSE 131
                 4455678888******************************997777665 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0024
      DUF641  85 sllktyeitvkkleaelkakdseieeLkek 114
                 ++lk y +   k+ + ++ ++sei++L+++
  EFC38848.1 178 RKLKHYRTIYCKIMQYVEVRESEIKQLENE 207
                 67899999999**************99875 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.015
      DUF641  70 eaeeseleaeiqeqrsllktyeitvkkleaelkakdseieeLkekLeeaeksnk 123
                 +a+ ++l  +  e  s +++   t+ + +++ + k+++ie Lkek+++ae +++
  EFC38848.1 223 DADIEHLIGKRAEMESRIESSFNTIIEKKRDNELKRQNIEILKEKVSQAEIKTQ 276
                 45566666777777888888888888889999**************99987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1950  (0.108762); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1768.24
//
Query:       EFC38849.1  [L=2866]
Description: rasGTPase-activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.2e-28   97.5   0.8    3.4e-24   85.7   0.0    4.3  2  RasGAP         GTPase-activator protein for Ras-like GTPase
    5.7e-19   68.6   2.3    5.7e-19   68.6   2.3    3.1  3  CRAL_TRIO_2    Divergent CRAL/TRIO domain
  ------ inclusion threshold ------
       0.13   12.5   3.4       0.81    9.9   0.9    3.3  2  DUF4047        Domain of unknown function (DUF4047)
        1.4    8.8   8.4       0.76    9.7   0.4    4.5  5  UNC45-central  Myosin-binding striated muscle assembly centra


Domain annotation for each model (and alignments):
>> RasGAP  GTPase-activator protein for Ras-like GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.3      0.18     8e+02      75     107 ..     216     284 ..     115     404 .. 0.64
   2 !   85.7   0.0   7.6e-28   3.4e-24       2     208 .]    1347    1529 ..    1346    1529 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.18
      RasGAP  75 kkkesktgkk....................................sessgkksekeaselekvsqmle 107
                 k+k+s ++++                                    +++  ++ ++e++++++v+++le
  EFC38849.1 216 KQKKSSSKSQrnfnvkrsaatftqpkeldeatalniiqlvstrlllQHDMFYDATQEEIQKTAVNNYLE 284
                 222222222244555555555555555555555555555555555544444444444444444444444 PP

  == domain 2  score: 85.7 bits;  conditional E-value: 7.6e-28
      RasGAP    2 iseliklEles..senpndllrsnsvvsklleeytkrpegqeyLkkilkpllqkilekedlnlelDPrkiyeelkkkkesktgkksessgkksekea 96  
                  +++ ++ E++   +++p++l+r+ns+ +kll++y+ r     yL  ++++++  ++ ++  ++e+DP k ++                         
  EFC38849.1 1347 FRQSVTREVATtpKSQPETLFRANSTSTKLLKKYCLR-VSNPYLTTVIGGFIDTMC-TKPTKFEIDPLKAQQR------------------------ 1417
                  677788888554599**********************.*****************9.99999*******9977........................ PP

      RasGAP   97 selekvsqmleknldkLkelvneildsIfksleqlPvgiRiickqirekvkekfpdas...eeei....lnligsflflrfliPaivnPklfglvdk 186 
                         + +e+n++++ e+ +e++d ++ s++q P+  R+ c+ ++e v +kf++ +   +e +    + ++g+fl+lr ++Pai++P+l+gl  +
  EFC38849.1 1418 ------GESVEENVENILEVLQEFIDCLCDSVQQTPYTFRMYCRYLYEEVGKKFTKPDddnDE-QfdfkYIAVGGFLILRLICPAITSPHLYGLSGS 1507
                  ......3457889*****************************************766633333.3585566789*********************** PP

      RasGAP  187 qiseeqrrnLtliaKllqnlan 208 
                   i  ++rr  + + Kl+qnlan
  EFC38849.1 1508 DIPADSRRYAIILTKLVQNLAN 1529
                  ********************97 PP

>> CRAL_TRIO_2  Divergent CRAL/TRIO domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0         2     9e+03      18      40 ..    1427    1449 ..    1422    1453 .. 0.86
   2 !   68.6   2.3   1.3e-22   5.7e-19       2     113 ..    1709    1817 ..    1708    1834 .. 0.90
   3 ?   -3.1   0.1       1.7   7.8e+03      62      77 ..    2800    2815 ..    2681    2844 .. 0.59

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2
  CRAL_TRIO_2   18 dldkllryvlhtladkivgkeyv 40  
                   +  ++l+ +++ l+d +++ +y+
   EFC38849.1 1427 NILEVLQEFIDCLCDSVQQTPYT 1449
                   66789*************99997 PP

  == domain 2  score: 68.6 bits;  conditional E-value: 1.3e-22
  CRAL_TRIO_2    2 rpVfvfiaafllsskadldkllryvlhtladkivgkeyvlVyfhtglssenkpslswlkkvystlprrykknlkklyivhpstfvktllktvlsaf 97  
                   + +++fi+ +l  ++ +ld +l+yvl+ + ++i++++y++V+++t l+++ +++ls++ ++ +++p+ +kknl+++y+v+p+tf+ +++k ++s++
   EFC38849.1 1709 QRIVYFIPYNLDLTRFSLDLYLYYVLKSM-ETIWKEPYIIVVDSTFLTKKFDIRLSVFIQLSKHIPQGAKKNLQEIYLVNPNTFFNKTTKKLVSML 1803
                   679********87899*************.***********************************************************9****99 PP

  CRAL_TRIO_2   98 vsskfrkkveyvsrle 113 
                   ++++   kv+  s+l 
   EFC38849.1 1804 SHNRW--KVITTSSLP 1817
                   88866..666666665 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.7
  CRAL_TRIO_2   62 vystlprrykknlkkl 77  
                   +++t    +kk+++k+
   EFC38849.1 2800 TFQTTKDDLKKKCQKT 2815
                   2333333344444444 PP

>> DUF4047  Domain of unknown function (DUF4047)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.9   0.00018      0.81      69     112 ..    1591    1634 ..    1545    1642 .. 0.78
   2 ?    0.3   0.1      0.17   7.5e+02      50      89 ..    2097    2140 ..    2072    2144 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00018
     DUF4047   69 wkqgrekikaerealqkvyteieepynqvqeelkvnksesskqv 112 
                  ++  ++   + re l  +y +ie+  + v ee+ +n++ sskq 
  EFC38849.1 1591 YRFFYNYADTLREELSSLYDDIEDEEKEVLEEVDINEKPSSKQN 1634
                  455555566789*****************************995 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.17
     DUF4047   50 mksklkvdsveeieqalsvwkqgrekikaere....alqkvyte 89  
                   +  + vd v+e    ++ w +++ k+    e     lq+v+++
  EFC38849.1 2097 FEISTSVDEVDEKTETIKNWFENFTKLCIANEeiypKLQNVWKH 2140
                  55667888888888899999999999877666233346777665 PP

>> UNC45-central  Myosin-binding striated muscle assembly central
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.1       2.6   1.2e+04      29      54 ..     266     292 ..     245     298 .. 0.65
   2 ?   -3.4   0.0       1.9   8.4e+03     118     140 ..    1042    1064 ..    1038    1069 .. 0.82
   3 ?   -3.9   0.0       2.7   1.2e+04       4      32 ..    1212    1240 ..    1208    1283 .. 0.71
   4 ?    0.2   0.0      0.14   6.4e+02      13      65 ..    1508    1591 ..    1487    1599 .. 0.69
   5 ?    9.7   0.4   0.00017      0.76      34     118 ..    2694    2779 ..    2676    2785 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 2.6
                    HHHHHHHHHH.HHHHHHHHHHHSCCTH CS
  UNC45-central  29 lldaakeefe.eaiseflesllekgde 54 
                    ++da++ee++  a++++le+++++  +
     EFC38849.1 266 FYDATQEEIQkTAVNNYLEQQISYRCM 292
                    447766666526799999999887655 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.9
                     SHHHHHHHHHHHHHHHH-SSHH. CS
  UNC45-central  118 rkaiaknyvewLeelvkssddek 140 
                      ++  ++y+ +L+ +v++ d++ 
     EFC38849.1 1042 NNLLVDQYLHILKTIVENPDTNT 1064
                     577899***********999875 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 2.7
                     HHHHHHC-T---TTHHHHHHHHHHHHHHH CS
  UNC45-central    4 dlllkfldmrqpesvrslallilskllda 32  
                      +ll+fl   + ++  ++++ ++s+ll++
     EFC38849.1 1212 AFLLRFLEKAKDSTFTATIYKAFSRLLQT 1240
                     57788888877777788888788887754 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.14
                     ---TTHHHHHHHHHHHHH........HHHHHHHHHHHHHHHHHHH........................SCCTHHHHHHHHHHHH CS
  UNC45-central   13 rqpesvrslallilskll........daakeefeeaiseflesll........................ekgdeddllnalsvlt 65  
                     + p++ r  a ++ +kl         d++keef + + ++++  l                        e  +ed+l++a++vl 
     EFC38849.1 1508 DIPADSRRYAIIL-TKLVqnlangivDSKKEEFMKNFVDIIRLNLnkiqtyfekiaapiveneevlrieETVTEDELKEAYEVLY 1591
                     5566666666554.45555779999999999999999999988887666666666677777777777777777777777776665 PP

  == domain 5  score: 9.7 bits;  conditional E-value: 0.00017
                     HHHHHHHHHHHHHHHH.SCCTHHHHHHHHHHHHHHHHSSHHHHHHHHTSTTHHHHHHHHHHS.S-HHHHHHHHHHHHTT--SSSSS CS
  UNC45-central   34 keefeeaiseflesll.ekgdeddllnalsvltalFpvvpdvasalflsegflesllelveskkskkvqlaalellsaAcidkkcr 118 
                     ++e+   ++++l s+  + +d d++  +++ l+  F+ +pd  + +f+    ++ +++  +s+++ ++ +  l+l+ + + ++k  
     EFC38849.1 2694 TKETVFLFQKYLFSITaSNIDLDSCASVYRSLARGFEAIPDTFADVFQDHHSMSQVIKVYTSSQDDTIIEHSLNLFKIMSNNAKSK 2779
                     55566677777777777899****************************************99999999999999998877776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2866 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1093  (0.0609627); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.17u 0.31s 00:00:01.48 Elapsed: 00:00:00.52
# Mc/sec: 16600.35
//
Query:       EFC38850.1  [L=173]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-18   67.4   0.0    1.8e-18   67.2   0.0    1.0  1  ERAP1_C   ERAP1-like C-terminal domain


Domain annotation for each model (and alignments):
>> ERAP1_C  ERAP1-like C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.2   0.0   9.9e-23   1.8e-18     132     283 ..      25     167 ..       7     173 .] 0.86

  Alignments for each domain:
  == domain 1  score: 67.2 bits;  conditional E-value: 9.9e-23
                 HHHHHHTT-HHHHHHHHHHHHHHHCSTT-S-HHHHHHHHHHHHHHS-HHHHHHHHHHHHC-SSHHHHHHHHHHH.CC-S-HHHHHHHHHHCTTT..S-G CS
     ERAP1_C 132 lsaacaagdpevveearklfkawlegddlippdlrwavycalaanggeaewdallerykdtsapsekeaalral.aatpdpellerllnfvlesdevrn 229
                 l++ac++g  e+v+ea k++++  +    ipp lr+avy+a+++ngge e+ ++l+++k ++++ e++++++a+  +++ p    +++ f+   + v+ 
  EFC38850.1  25 LNLACRFGLTECVTEAFKRYQERNST--IIPPILRNAVYRAVVSNGGEREYYQILNQFKAEQDSVERTKLVYARfHSCKRP----WIWPFL---HHVKP 114
                 689*******************9432..6*****************************87777799*******95344444....579**9...57*** PP

                 GGHHHHHHHH..HSTTHHHHHHHHHHHCHCCHHHHTSSTSCHHHHHHHHHTT--S CS
     ERAP1_C 230 qdlrallagl.annpegrellwefvkenwdalakrwsggeildrivkgllpgfts 283
                 qd+ +l++ + +n p g  ++  fv++++da+ ++ ++ ++ +r+  g+ + ft+
  EFC38850.1 115 QDSIFLIREVaRNVPSGPNVA--FVRTRYDAILSKCGQDQVSNRLSYGVGSLFTN 167
                 **********55558888888..*************9877999999999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (173 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       388  (0.0216409); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.24s 00:00:00.68 Elapsed: 00:00:00.43
# Mc/sec: 1217.47
//
Query:       EFC38851.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.1e-32  109.2   3.2    3.8e-05   23.4   0.1    6.3  6  LRR_6      Leucine Rich repeat
    1.8e-20   72.7  13.8      3e-05   24.3   0.3    4.6  5  LRR_4      Leucine Rich repeats (2 copies)
    5.6e-18   64.4   3.1    4.8e-09   35.8   0.5    3.2  3  LRR_8      Leucine rich repeat
    5.2e-12   44.6   0.1        8.5    7.4   0.0    6.7  7  LRR_1      Leucine Rich Repeat
    2.7e-06   27.0   0.1      0.054   13.0   0.0    2.0  2  LRR_9      Leucine-rich repeat
    0.00014   21.7   5.1        4.4    7.4   0.0    5.1  6  ApoB100_C  Apolipoprotein B100 C terminal
    0.00085   19.6   3.5        3.8    7.9   0.1    4.0  5  CLU_N      Mitochondrial function, CLU-N-term
     0.0013   18.7   0.2         24    4.7   0.0    4.6  6  DUF4347    Domain of unknown function (DUF4347)
     0.0059   16.5   2.4        1.9    8.5   0.1    2.9  2  DUF1825    Domain of unknown function (DUF1825)
     0.0089   15.9   3.3         36    4.3   0.1    5.1  6  CBM32      Carbohydrate binding module family 32
  ------ inclusion threshold ------
       0.03   14.2   0.1       0.13   12.1   0.0    1.8  2  DUF244     Uncharacterized protein family (ORF7) DUF


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0     0.001       1.6       5      19 ..       4      18 ..       2      23 .. 0.89
   2 !   22.8   0.0   3.7e-08   6.1e-05       5      23 ..      28      46 ..      25      47 .. 0.91
   3 !   14.7   0.0   1.4e-05     0.023       5      24 .]      52      71 ..      49      71 .. 0.93
   4 !   12.7   0.0   6.2e-05       0.1       5      24 .]      76      95 ..      73      95 .. 0.91
   5 !   21.6   0.0   8.8e-08   0.00014       5      24 .]     100     119 ..      97     119 .. 0.92
   6 !   23.4   0.1   2.4e-08   3.8e-05       5      24 .]     124     143 ..     120     143 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.001
       LRR_6  5 LteLdLsgNdIgDeG 19
                Lt+Ld+ +N+Ig eG
  EFC38851.1  4 LTSLDIYYNEIGVEG 18
                9***********999 PP

  == domain 2  score: 22.8 bits;  conditional E-value: 3.7e-08
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+L++++N IgDeGa+ +
  EFC38851.1 28 LTSLNINYNRIGDEGAKFI 46
                9***************987 PP

  == domain 3  score: 14.7 bits;  conditional E-value: 1.4e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+  N+Ig eG+++++
  EFC38851.1 52 LTSLDIYNNEIGVEGVKSIS 71
                9****************996 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 6.2e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L++sgN+ g eG++ ++
  EFC38851.1 76 LTSLNISGNQSGAEGVKLIS 95
                9***************9885 PP

  == domain 5  score: 21.6 bits;  conditional E-value: 8.8e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++++N IgDeG++ ++
  EFC38851.1 100 LTSLSINYNRIGDEGVKLIS 119
                 9****************986 PP

  == domain 6  score: 23.4 bits;  conditional E-value: 2.4e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +Ld+sgN+IgDeGa+ ++
  EFC38851.1 124 LASLDISGNGIGDEGAKLIS 143
                 779**************986 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.1   4.3e-07   0.00071       1      38 [.       2      40 ..       2      42 .. 0.84
   2 !   24.3   0.3   1.8e-08     3e-05       1      36 [.      26      62 ..      26      68 .. 0.87
   3 !   21.7   0.3   1.2e-07   0.00019       1      33 [.      50      84 ..      50      88 .. 0.82
   4 !   21.2   0.0   1.7e-07   0.00027       1      37 [.      98     135 ..      98     139 .. 0.87
   5 !   16.3   0.1   5.8e-06    0.0095       2      33 ..     123     155 ..     122     158 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 4.3e-07
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38
                ++L++Ld+  N +   ++ + + +++L++L+++ N +i+d
  EFC38851.1  2 KQLTSLDIYYNEIGVEGSkFISdMKQLTSLNINYN-RIGD 40
                58************766686655*********777.7765 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 1.8e-08
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36
                ++L++L+++ N++ d +  + + +++L++Ld+  Nn i
  EFC38851.1 26 KQLTSLNINYNRIGDEGAkFISeMKQLTSLDI-YNNEI 62
                58*************999*6655*********.77676 PP

  == domain 3  score: 21.7 bits;  conditional E-value: 1.2e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33
                ++L++Ld+ nN +   +   ++ +++L++L++sgN
  EFC38851.1 50 KQLTSLDIYNNEIGVEGVksISEMKQLTSLNISGN 84
                58**********88655565335***********9 PP

  == domain 4  score: 21.2 bits;  conditional E-value: 1.7e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L+++ N++ d +   ++k+++L +Ld+sgN  i+
  EFC38851.1  98 KQLTSLSINYNRIGDEGVklISKMKQLASLDISGN-GIG 135
                 58*************99995557***********9.665 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 5.8e-06
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgN 33 
                 +L +Ld+s+N + d +  l + +++Lk+L++ +N
  EFC38851.1 123 QLASLDISGNGIGDEGAkLISeMKQLKSLSI-HN 155
                 5778**********99996655*********.88 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.1     8e-07    0.0013       2      37 ..       3      38 ..       2      40 .. 0.80
   2 !   35.8   0.5   2.9e-12   4.8e-09       2      60 ..      27      85 ..      26      85 .. 0.98
   3 !   22.7   0.1   3.8e-08   6.2e-05       2      58 ..      99     155 ..      97     158 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 8e-07
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37
                +LtsLd+  N + + + ++ +++++L++L++++N++
  EFC38851.1  3 QLTSLDIYYNEIGVEGSKFISDMKQLTSLNINYNRI 38
                688888888888888888888888888888888877 PP

  == domain 2  score: 35.8 bits;  conditional E-value: 2.9e-12
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60
                +LtsL+++ Nr+ + + ++ + +++L++Ld+ nN++ +   +++s +++L+sL++sgN+
  EFC38851.1 27 QLTSLNINYNRIGDEGAKFISEMKQLTSLDIYNNEIGVEGVKSISEMKQLTSLNISGNQ 85
                7*********************************************************7 PP

  == domain 3  score: 22.7 bits;  conditional E-value: 3.8e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +LtsL+++ Nr+ + + +  +++++L +Ld+s N +    ++ +s +++L+sL + +
  EFC38851.1  99 QLTSLSINYNRIGDEGVKLISKMKQLASLDISGNGIGDEGAKLISEMKQLKSLSIHN 155
                 79***************************************************9876 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.041        67       1      17 [.       3      19 ..       3      25 .. 0.77
   2 !    7.4   0.0    0.0052       8.5       1      18 [.      27      44 ..      27      49 .. 0.80
   3 !    6.7   0.0    0.0086        14       1      21 [.      51      71 ..      51      73 .. 0.82
   4 !    6.6   0.0    0.0095        16       1      12 [.      75      86 ..      75      96 .. 0.82
   5 ?    4.8   0.0     0.036        59       1      20 [.      99     118 ..      99     121 .. 0.78
   6 ?    5.1   0.0     0.029        48       2      18 ..     124     140 ..     123     145 .. 0.76
   7 ?   -0.1   0.0       1.5   2.4e+03       1      10 [.     147     156 ..     147     159 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.041
       LRR_1  1 nLrhLdLsnnpllglpp 17
                +L++Ld+ +n ++  ++
  EFC38851.1  3 QLTSLDIYYNEIGVEGS 19
                599*******9965555 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0052
       LRR_1  1 nLrhLdLsnnpllglppn 18
                +L++L++++n++++ ++ 
  EFC38851.1 27 QLTSLNINYNRIGDEGAK 44
                599********9877665 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0086
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++Ld+ nn ++  +  s++
  EFC38851.1 51 QLTSLDIYNNEIGVEGVKSIS 71
                599********9887777765 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0095
       LRR_1  1 nLrhLdLsnnpl 12
                +L++L++s+n+ 
  EFC38851.1 75 QLTSLNISGNQS 86
                599*******96 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.036
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L +++n++++ +   +
  EFC38851.1  99 QLTSLSINYNRIGDEGVKLI 118
                 599********987766555 PP

  == domain 6  score: 5.1 bits;  conditional E-value: 0.029
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L +Ld+s+n +++ ++ 
  EFC38851.1 124 LASLDISGNGIGDEGAK 140
                 669******99776655 PP

  == domain 7  score: -0.1 bits;  conditional E-value: 1.5
       LRR_1   1 nLrhLdLsnn 10 
                 +L++L + n+
  EFC38851.1 147 QLKSLSIHNQ 156
                 599**99886 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.0   3.3e-05     0.054      45     123 ..       5      84 ..       1      90 [. 0.76
   2 !   12.6   0.0   4.5e-05     0.073      62     124 ..      96     157 ..      86     160 .] 0.90

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.3e-05
       LRR_9  45 dtidlsdndirkldgfPl...lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                  ++d+  n+i  ++g  +   +k+l +l +n nri   + ++   + +l++l + nne+  +  ++ + ++k+l++l +  n
  EFC38851.1   5 TSLDIYYNEIG-VEGSKFisdMKQLTSLNINYNRIGDEGAKFISEMKQLTSLDIYNNEIG-VEGVKSISEMKQLTSLNISGN 84 
                 55666666663.34433311278899999******99999999999************97.566799999999999988766 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 4.5e-05
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                  +k+l +l++n nri   + +l   + +l +l +++n + + +  + + ++k+l++ls+ +  
  EFC38851.1  96 EMKQLTSLSINYNRIGDEGVKLISKMKQLASLDISGNGIGDEGA-KLISEMKQLKSLSIHNQQ 157
                 5899************************************9988.88999********97765 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.19     3e+02      19      33 ..      20      34 ..      10      36 .. 0.87
   2 ?    5.3   0.0     0.012        20      10      33 ..      35      58 ..      30      62 .. 0.85
   3 ?   -2.0   0.0       2.3   3.7e+03      20      32 ..      69      81 ..      68      83 .. 0.80
   4 ?    4.3   0.1     0.025        40      19      33 ..      92     106 ..      90     110 .. 0.91
   5 ?    1.7   0.0      0.16   2.6e+02      11      32 ..     108     129 ..     106     131 .. 0.80
   6 !    7.4   0.0    0.0027       4.4      19      38 ..     140     159 ..     132     160 .] 0.91

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.19
   ApoB100_C 19 kliaeskrLiDLsIe 33
                k+i+  k+L  L I+
  EFC38851.1 20 KFISDMKQLTSLNIN 34
                9********999985 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.012
   ApoB100_C 10 sdqlsdyyEkliaeskrLiDLsIe 33
                ++++ d   k+i+e k+L  L I 
  EFC38851.1 35 YNRIGDEGAKFISEMKQLTSLDIY 58
                678888889*********999885 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 2.3
   ApoB100_C 20 liaeskrLiDLsI 32
                 i+e k+L  L I
  EFC38851.1 69 SISEMKQLTSLNI 81
                5899999998887 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.025
   ApoB100_C  19 kliaeskrLiDLsIe 33 
                 kli+e k+L  LsI+
  EFC38851.1  92 KLISEMKQLTSLSIN 106
                 8************95 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.16
   ApoB100_C  11 dqlsdyyEkliaeskrLiDLsI 32 
                 +++ d   kli++ k+L  L I
  EFC38851.1 108 NRIGDEGVKLISKMKQLASLDI 129
                 666666779********99987 PP

  == domain 6  score: 7.4 bits;  conditional E-value: 0.0027
   ApoB100_C  19 kliaeskrLiDLsIekYhaf 38 
                 kli+e k+L  LsI + ++f
  EFC38851.1 140 KLISEMKQLKSLSIHNQQMF 159
                 9***************9998 PP

>> CLU_N  Mitochondrial function, CLU-N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.2     0.036        59      19      45 ..       2      31 ..       1      37 [. 0.71
   2 ?    2.5   0.0      0.11   1.9e+02      14      29 ..      21      36 ..      19      45 .. 0.77
   3 !    7.9   0.1    0.0023       3.8      14      49 ..      45      83 ..      40      93 .. 0.77
   4 ?    5.5   0.0     0.013        21      13      43 ..      92     125 ..      88     141 .. 0.74
   5 ?    1.0   0.0      0.35   5.7e+02      13      47 ..     116     153 ..     113     158 .. 0.71

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.036
       CLU_N 19 kylTnyhLkye..ng.ngerlnefvtlsei 45
                k+lT+ +++y+  ++  ++ ++++++l  +
  EFC38851.1  2 KQLTSLDIYYNeiGVeGSKFISDMKQLTSL 31
                789999999987655455556888888766 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.11
       CLU_N 14 elpstkylTnyhLkye 29
                +++ +k+lT+ +++y+
  EFC38851.1 21 FISDMKQLTSLNINYN 36
                57889********996 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.0023
       CLU_N 14 elpstkylTnyhLkye..ng.ngerlnefvtlseiieee 49
                +++++k+lT+ +++++  ++   ++++e+++l  +  ++
  EFC38851.1 45 FISEMKQLTSLDIYNNeiGVeGVKSISEMKQLTSLNISG 83
                67899********88877666778888888888775555 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.013
       CLU_N  13 selpstkylTnyhLkye..ng.ngerlnefvtls 43 
                 ++++++k+lT+ +++y+  ++   + ++ +++l 
  EFC38851.1  92 KLISEMKQLTSLSINYNriGDeGVKLISKMKQLA 125
                 67899**********9865333445556666655 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.35
       CLU_N  13 selpstkylTnyhLkye..ng.ngerlnefvtlseiie 47 
                 ++++++k+l + ++  +  ++   + ++e+++l+ ++ 
  EFC38851.1 116 KLISKMKQLASLDISGNgiGDeGAKLISEMKQLKSLSI 153
                 56788899999999777764435666799999988755 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.0     0.027        43      95     121 ..       9      33 ..       1      39 [. 0.78
   2 ?    4.7   0.0     0.015        24     103     122 ..      39      58 ..      36      64 .. 0.89
   3 ?    1.8   0.0      0.12   1.9e+02      86     122 ..      48      82 ..      43      88 .. 0.67
   4 ?    2.0   0.0      0.11   1.7e+02     103     121 ..      87     105 ..      67     112 .. 0.82
   5 ?    1.6   0.0      0.14   2.2e+02     103     122 ..     111     130 ..     106     139 .. 0.88
   6 ?   -0.7   0.0      0.71   1.2e+03     103     121 ..     135     153 ..     130     157 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.027
     DUF4347  95 lYgCnvAageaGeafvekLaqltgadv 121
                 +Y  +++   +G++f+++++qlt  ++
  EFC38851.1   9 IYYNEIGV--EGSKFISDMKQLTSLNI 33 
                 55555555..5************9998 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.015
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +f+++++qlt  d+ 
  EFC38851.1  39 GDEGAKFISEMKQLTSLDIY 58 
                 689*************9996 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.12
     DUF4347  86 alsedadillYgCnvAageaGeafvekLaqltgadva 122
                 ++++   + +Y  +++ +  G + +++++qlt  +++
  EFC38851.1  48 EMKQLTSLDIYNNEIGVE--GVKSISEMKQLTSLNIS 82 
                 455555666777777665..88888888888888876 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.11
     DUF4347 103 geaGeafvekLaqltgadv 121
                 g++G +++++++qlt  ++
  EFC38851.1  87 GAEGVKLISEMKQLTSLSI 105
                 6679999999999999877 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.14
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G ++++k++ql   d++
  EFC38851.1 111 GDEGVKLISKMKQLASLDIS 130
                 689************99996 PP

  == domain 6  score: -0.7 bits;  conditional E-value: 0.71
     DUF4347 103 geaGeafvekLaqltgadv 121
                 g++G +++++++ql   ++
  EFC38851.1 135 GDEGAKLISEMKQLKSLSI 153
                 7899999999999988776 PP

>> DUF1825  Domain of unknown function (DUF1825)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.1    0.0011       1.9      12      49 ..      17      53 ..       7      79 .. 0.89
   2 !    6.7   0.4    0.0042       6.9      12      49 ..      89     125 ..      84     160 .] 0.73

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0011
     DUF1825 12 eakelfqdyqeliqlgskygkfdreGkkifiekleell 49
                e  ++ +d+++l  l  +y +   eG k fi ++ +l 
  EFC38851.1 17 EGSKFISDMKQLTSLNINYNRIGDEGAK-FISEMKQLT 53
                667899********************87.999999885 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0042
     DUF1825  12 eakelfqdyqeliqlgskygkfdreGkkifiekleell 49 
                 e  +l +++++l  l  +y +   eG k+ i k+ +l 
  EFC38851.1  89 EGVKLISEMKQLTSLSINYNRIGDEGVKL-ISKMKQLA 125
                 56689999******************986.88998875 PP

>> CBM32  Carbohydrate binding module family 32
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.13   2.1e+02      11      26 ..      20      35 ..      18      38 .. 0.83
   2 ?   -1.3   0.0       1.3     2e+03      11      22 ..      44      55 ..      43      65 .. 0.76
   3 ?   -0.9   0.0      0.95   1.5e+03      11      25 ..      68      82 ..      65      87 .. 0.77
   4 ?    3.1   0.0     0.051        83      11      26 ..      92     107 ..      89     110 .. 0.87
   5 ?    1.5   0.0      0.17   2.7e+02      11      25 ..     116     130 ..     114     134 .. 0.82
   6 ?    4.3   0.1     0.022        36      11      25 ..     140     154 ..     138     158 .. 0.87

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.13
                BEEESSCCCTTS-EEE CS
       CBM32 11 klesnveQLknlPlql 26
                k +s+ +QL +l + +
  EFC38851.1 20 KFISDMKQLTSLNINY 35
                789******9997765 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.3
                BEEESSCCCTTS CS
       CBM32 11 klesnveQLknl 22
                k +s+ +QL +l
  EFC38851.1 44 KFISEMKQLTSL 55
                678999999877 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.95
                BEEESSCCCTTS-EE CS
       CBM32 11 klesnveQLknlPlq 25
                k +s+ +QL +l ++
  EFC38851.1 68 KSISEMKQLTSLNIS 82
                668999999988765 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.051
                 BEEESSCCCTTS-EEE CS
       CBM32  11 klesnveQLknlPlql 26 
                 kl+s+ +QL +l++ +
  EFC38851.1  92 KLISEMKQLTSLSINY 107
                 99*********99876 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.17
                 BEEESSCCCTTS-EE CS
       CBM32  11 klesnveQLknlPlq 25 
                 kl+s  +QL++l ++
  EFC38851.1 116 KLISKMKQLASLDIS 130
                 89********98665 PP

  == domain 6  score: 4.3 bits;  conditional E-value: 0.022
                 BEEESSCCCTTS-EE CS
       CBM32  11 klesnveQLknlPlq 25 
                 kl+s+ +QLk+l++ 
  EFC38851.1 140 KLISEMKQLKSLSIH 154
                 89*********9976 PP

>> DUF244  Uncharacterized protein family (ORF7) DUF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.1     0.034        56      75     113 ..      21      59 ..       4      61 .. 0.83
   2 ?   12.1   0.0     8e-05      0.13      38     103 ..      53     121 ..      33     131 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.034
      DUF244  75 laydlmeidslqkelnriqnenkkrekpikdrlkmliyn 113
                 +  d+ ++ sl+ + nri +e  k    +k+   + iyn
  EFC38851.1  21 FISDMKQLTSLNINYNRIGDEGAKFISEMKQLTSLDIYN 59 
                 567899999*************99999999998888988 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 8e-05
      DUF244  38 ersdfyssevefdwarefieyvdcadleikdnqs.ae..nlaydlmeidslqkelnriqnenkkrekpi 103
                    d+y  e+ ++ ++ + e  + + l+i  nqs ae  +l  ++ ++ sl  + nri +e  k    +
  EFC38851.1  53 TSLDIYNNEIGVEGVKSISEMKQLTSLNISGNQSgAEgvKLISEMKQLTSLSINYNRIGDEGVKLISKM 121
                 3469*****************************944433578899999***********9988765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       432  (0.024095); expected 358.6 (0.02)
Passed bias filter:                      253  (0.0141112); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1001.80
//
Query:       EFC38852.1  [L=1113]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      3e-07   31.2   0.0    6.8e-07   30.1   0.0    1.6  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
       0.76   10.9   0.0       0.76   10.9   0.0    3.5  2  RNase_J_C       Ribonuclease J C-terminal domain
          5    7.6  11.2         11    6.5  11.2    1.5  1  SOBP            Sine oculis-binding protein
        6.1    6.5  20.1        1.8    8.3  16.7    1.8  2  AAA_11          AAA domain


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.0   1.5e-10   6.8e-07       2      94 ..     177     264 ..     176     266 .. 0.75

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 1.5e-10
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....E.T-B--EEE..............---TT-EEEEE-..B-TEEE--B.-SS-EEEE CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekes.eeGGelelyekdk....eavkikpkkgrlvlFesdellpHevlpvtkggeRlsl 91 
                     ++l y++g++++ H D+    e++ ++++t+++ L    s +eGGe+++ ++d      +++       ++ F+sd+   H+v+p t+g  R +l
      EFC38852.1 177 KLLLYEKGGHFEYHKDS----EKECKQTCTLVIILP---SiFEGGEFKIKHNDYemeiATTNDYATDCHFISFYSDCD--HAVMPLTSG-YRTCL 261
                     6889************7....455789********3...57********444434443222222355555*****999..******886.99888 PP

                     EEE CS
  2OG-FeII_Oxy_3  92 tgw 94 
                      ++
      EFC38852.1 262 IYN 264
                     765 PP

>> RNase_J_C  Ribonuclease J C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00017      0.76      24      66 ..     264     306 ..     261     308 .. 0.90
   2 ?   -5.6   8.7         4   1.8e+04      12      58 ..     904     950 ..     902     953 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00017
   RNase_J_C  24 kvvretieealeekesdwnelkrkirealkkflykktkrrPmI 66 
                 +++  t +e+++ +++d+++ ++++re+l+++l++ + ++P++
  EFC38852.1 264 NIIVTTHQENQQLSIADNHVHSENVREQLSEWLKTDLSKKPLV 306
                 67777888888889***************************98 PP

  == domain 2  score: -5.6 bits;  conditional E-value: 4
   RNase_J_C  12 vkeseeLieeakkvvretieealeekesdwnelkrkirealkkflyk 58 
                 ++e++ L+++ +k  ++ +++  ee++++ +++++++++  k+ ++k
  EFC38852.1 904 KREEQRLLKKKQKEEENRLKKEREEEDKELRKVEKELKKRKKEEIKK 950
                 589999*******************99**999999999988877776 PP

>> SOBP  Sine oculis-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  11.2    0.0025        11      81     242 ..     850    1007 ..     837    1064 .. 0.40

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0025
        SOBP   81 saspaskrsesvspeps.....ksaspsssptssnsskplisvassskll.aeksqepaslveaplepkkqrkkkpglrkpkqvkagsskssetkag 171 
                  + spa ++s++ + e       ++  +++    ++++k l++ + +++ l ++k++e + l ++     kq++++++l+k+++ + ++ +++e++ +
  EFC38852.1  850 ASSPAGEESVKREAERVekekkERLEREEAKKREAEEKLLQKKKLEEEALlKKKKREEQRLLKK-----KQKEEENRLKKEREEEDKELRKVEKELK 941 
                  4555555444444332222211111111111122222222222222222202222222222222.....2222222222222222121112221111 PP

        SOBP  172 llqkq.....qkalplsaeleessvpkpflrpppsiqelqsslpnqslpkiapppkppstlappsngaerppfspl 242 
                  +         +k+ p +a  ++ss     +  ++++q+ +s++++q + ++++ +     l++  +++++ p+ p 
  EFC38852.1  942 K---RkkeeiKKEQPTPASSSQSS--STINTQSHTVQGTNSAIQTQPIVPQLTCQ-----LGTVYSQMQGMPLVPI 1007
                  1...11223344445555555543..33333444444555555554444333333.....3444444444444443 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1      0.85   3.8e+03     170     213 ..     459     503 ..     408     509 .. 0.75
   2 ?    8.3  16.7   0.00041       1.8      69     190 ..     825     945 ..     771     984 .. 0.54

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 0.85
      AAA_11 170 lkkerkelskeleeaeesle.eevldeaeivltTlsgagskllek 213
                  +++++e+ ++++++e +l  ++ +++ e+ + Tl + g+k+l+k
  EFC38852.1 459 ESEQINEFYESFTKEEWKLPyRHTISKQEMFVMTLIKTGKKDLTK 503
                 444455555555555555435777777777777887777777765 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00041
      AAA_11  69 ellerllrglldsegekykpkivRvgneeeriseavksvsleekvekrlekeekaqlakeiskeleklakelrafeeeeekeklkkskekskskleqer 167
                 ell+ l+    +++ ++ + ++ R+ +++++ +e+vk+    e+vek+++++   +   ++++++ekl ++ + +ee   k+k++++++  k+k+++e+
  EFC38852.1 825 ELLQFLIH-HQTDKDSRPQFSFTRITASSPAGEESVKREA--ERVEKEKKER-LEREEAKKREAEEKLLQKKKLEEEALLKKKKREEQRLLKKKQKEEE 919
                 44444555.44445667788999***99955555555555..4444444332.2222222222222222222223333333344444444444444444 PP

      AAA_11 168 rklkkerkelskeleeaeesle...e 190
                 + lkker+e +kel+++e++l+   +
  EFC38852.1 920 NRLKKEREEEDKELRKVEKELKkrkK 945
                 44444444444444444444432221 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1113 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2769  (0.154443); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                       163  (0.00909142); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.25u 0.36s 00:00:01.61 Elapsed: 00:00:00.56
# Mc/sec: 5945.42
//
Query:       EFC38853.1  [L=606]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     3e-106  353.8   0.0   4.4e-106  353.3   0.0    1.2  1  ATP-synt_ab      ATP synthase alpha/beta family, nucleotide-b
    5.1e-42  142.6   0.0      1e-41  141.6   0.0    1.6  1  ATP-synt_ab_Xtn  ATPsynthase alpha/beta subunit N-term extens
    2.7e-16   59.8   2.8    2.7e-16   59.8   2.8    2.3  2  ATP-synt_ab_N    ATP synthase alpha/beta family, beta-barrel 


Domain annotation for each model (and alignments):
>> ATP-synt_ab  ATP synthase alpha/beta family, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  353.3   0.0  7.3e-110  4.4e-106       1     213 []     220     447 ..     220     447 .. 0.98

  Alignments for each domain:
  == domain 1  score: 353.3 bits;  conditional E-value: 7.3e-110
                  SSHHHHHHS-EBTT-EEEEEESTTSSHHHHHHHHHHHSSTSSEEEEEEESEEHHHHHHHHHHCHH........SS...GGGGEEEEEEETTS-HHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xx...xxxxxxxxxxxxxxxxxxxx RF
  ATP-synt_ab   1 GirvlDalfpivqGqrtlipgafgvGktvisqslskqsnsddaiiyvgiGergnevaevleefpe........gt...imkrtvlvantsnepvaare 87 
                  G+rvlDa+fp vqG++++ipgafg+Gktvisq++sk+sns+ aiiyvg+Gergne+aevl+efp+        g+   im+rt+lvantsn+pvaare
   EFC38853.1 220 GQRVLDAVFPSVQGGTCAIPGAFGCGKTVISQAISKYSNSE-AIIYVGCGERGNEMAEVLMEFPHltvtnqktGKevsIMNRTCLVANTSNMPVAARE 316
                  9***************************************9.***********************9999987622578******************** PP

                  HHHHHHHHHHHHHHHTTSEEEEEEETHHHHHHHHHHHHHHTTTSBEGGGSBTTHHHHHHHHHTTSEEE.....TSSEEEEEEEEEEE-GGCSTTSHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxx RF
  ATP-synt_ab  88 asiytgitlAEyfrdqgknvlliadslsrwaeAlreislrlgempadqgypaylgaklaslyERagka.....pdrtGsvtivaavspaggDfsdpvt 180
                  asiytgitl+Eyfrd+g+nv ++ads+srwaeAlreis+rl empad+gypaylga+las+yERagk+     p rtGs+tiv avsp+ggDf dpvt
   EFC38853.1 317 ASIYTGITLSEYFRDMGMNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGKVrcignPGRTGSITIVGAVSPPGGDFADPVT 414
                  *************************************************************************99*********************** PP

                  HHHHHHSSEEEEB-HHHHHTTBSSSBCTTTEEE CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  ATP-synt_ab 181 tatlgitdgfivLdkklaqrkhfPainvlvSvS 213
                    tlgi+++f++LdkklaqrkhfP++n+l+S+S
   EFC38853.1 415 ASTLGIVQVFWGLDKKLAQRKHFPSVNWLISYS 447
                  ********************************9 PP

>> ATP-synt_ab_Xtn  ATPsynthase alpha/beta subunit N-term extension
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  141.6   0.0   1.7e-45     1e-41       1     121 []      89     211 ..      89     211 .. 0.98

  Alignments for each domain:
  == domain 1  score: 141.6 bits;  conditional E-value: 1.7e-45
                      EETTS-BHHHHHHHHTS..BE-TT----SS-SSS-EEEEE.SS-TT-EEETT-EEEEEECTTCEEEEEE--TT-EEEEEEE--EEEE-TTSECE CS
  ATP-synt_ab_Xtn   1 yDGiqrpLekiaeksgs..fierGvkvpaldrekkwefkp.kvkvgdkvsggdilGtvqeteliehkimvppkvegkvkeiaeegeytvedtia 91 
                      +DGiqrpLe i +++++  +i+rG++v++ld +k+w f+p +++ gdk++ggdi+G+v+e+++i+hki++pp++ g++++ia+ g+yt++d ++
       EFC38853.1  89 FDGIQRPLEVIYKNCNEdiYIPRGINVNSLDMDKNWFFNPtNFSIGDKITGGDIFGEVEENDFINHKILLPPGAMGEITYIASPGNYTLNDAVI 182
                      9*************9999**********************99**************************************************** PP

                      EECETT.ECEEEESSEEEETTS---ESEEE CS
  ATP-synt_ab_Xtn  92 eveteegkekeltllqkwPvrkprpvkekl 121
                      ev++++  ++++ +++ wPvr+prpv ekl
       EFC38853.1 183 EVDFNG-MKRQFGMAHFWPVRQPRPVIEKL 211
                      ***998.69******************996 PP

>> ATP-synt_ab_N  ATP synthase alpha/beta family, beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.8   2.8   4.5e-20   2.7e-16       1      69 []      11      73 ..      11      73 .. 0.98
   2 ?   -1.0   0.1      0.43   2.6e+03      29      46 ..     493     510 ..     463     511 .. 0.66

  Alignments for each domain:
  == domain 1  score: 59.8 bits;  conditional E-value: 4.5e-20
                   EEEEETTEEEEESSTSCETCTTEEEEECCETCSTEEEEEEEEEETTEEEEEESS-STTBBTTSEEEEES CS
  ATP-synt_ab_N  1 ivqviGpvvdvefgigrlpgiynalevelvefgtlllgvalnlgedkVrvivmgstdGlsrGteVkrTG 69
                   i +v+Gpvv +e+++g   ++y++++v+  +  ++l+g++++l++d++ ++v+++t+Gl +G++V rTG
     EFC38853.1 11 ILSVSGPVVVAEKMEG--AAMYELVRVG--N--QQLVGEIIRLEGDTATIQVYEETSGLTVGDPVLRTG 73
                   679*************..**********..9..99*********************************9 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.43
                    CETCSTEEEEEEEEEETT CS
  ATP-synt_ab_N  29 lvefgtlllgvalnlged 46 
                    l+e+ +++l+va  l+ed
     EFC38853.1 493 LPENDKVTLEVAKLLRED 510
                    334667777777666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (606 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       641  (0.0357521); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.34s 00:00:01.06 Elapsed: 00:00:00.55
# Mc/sec: 3329.25
//
Query:       EFC38854.1  [L=624]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.6e-28   97.4   0.9    2.3e-27   95.6   0.9    2.0  1  Sad1_UNC      Sad1 / UNC-like C-terminal
    3.9e-05   23.8   0.1    0.00031   20.8   0.0    2.6  2  F5_F8_type_C  F5/8 type C domain
  ------ inclusion threshold ------
       0.35   10.4   5.2        5.1    6.7   0.1    2.9  2  Fur_reg_FbpB  Fur-regulated basic protein B
        3.6    7.5  13.2        5.4    6.9   0.6    3.2  3  T6PP_N        Trehalose-6-phosphate phosphatase N-terminal he
        5.1    7.2  11.5       0.24   11.4   0.5    3.4  3  Ac76          Orf76 (Ac76)


Domain annotation for each model (and alignments):
>> Sad1_UNC  Sad1 / UNC-like C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.6   0.9   6.4e-31   2.3e-27       2     131 ..     153     280 ..     152     281 .. 0.91

  Alignments for each domain:
  == domain 1  score: 95.6 bits;  conditional E-value: 6.4e-31
                 EEE-B-GGGGGSS-...-STT-SEEEESS-EEEEEEEEEEEEEEEEEEE---GGGSG-TTSB-EEEEEEESSTT---....-EEEEEEE--TTS-SEEE CS
    Sad1_UNC   2 nkeakapkvilqed...yspgeCwsfkgsrgfvvieLseeiiveavtlehveksvapisSapKdfevsgskrypekk....wvllgefsydedgknaqt 93 
                 n+eak+++ il+ed   y + +  s+     ++v+eLseei +++++++++e     +s  +K+f+v++s +yp+k+    w+llg+f+ +++++++q 
  EFC38854.1 153 NREAKKVSRILNEDsdkYCLIPR-SVPK--KWIVVELSEEILMKSIAIANYEY----YSCSFKHFKVYASVKYPCKEksncWELLGTFQ-AANSRKVQH 243
                 67889999999999777555555.5555..5**********************....*******************99***********.9******** PP

                 EE--TT----EEEEEEEE--BS.S-SSEEEESEEEEEEE CS
    Sad1_UNC  94 Feleeskdilvkyvkleilsny.GneeytclyrlrVyGt 131
                 F++++++  +++yvkle+ls+y +ne+y++l++lrV+G+
  EFC38854.1 244 FTFKKPS--ITRYVKLEFLSHYgENEYYCTLSLLRVHGS 280
                 ******9..*************557889**********8 PP

>> F5_F8_type_C  F5/8 type C domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   8.7e-08   0.00031      14     119 ..     159     266 ..     142     273 .. 0.75
   2 ?   -2.0   0.3       1.1   3.8e+03      59     100 ..     480     524 ..     464     529 .. 0.72

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 8.7e-08
                   GGGGGSSSTTSSEE.ESSSSTTEEEEEEEEEEEEEEEEEEEECSSTTSSEEEEEEEEEE......SSSSSEEEEEEECEEESSSSSSSEEEEEEEEE CS
  F5_F8_type_C  14 aaaaldGnkntaWs.ssssddkqwlqvdLgkpkkidgvvtqgrqdggnayvksykiqvs......ddgetWttvkdekvpgnsdnstpvtntfdppv 103
                    + +l+ + + +++   +s +k+w+ v+L ++  ++++ + +     +   k++k++ s      +  + W+ + +    + +++ ++++ tf++p 
    EFC38854.1 159 VSRILNED-SDKYClIPRSVPKKWIVVELSEEILMKSIAIANYEYY-SCSFKHFKVYASvkypckEKSNCWELLGT---FQAANSRKVQHFTFKKPS 250
                   44555543.3355544444555********************9554.999*********99988544568977777...44444469********** PP

                   EEEEEEEEEEEEESSS CS
  F5_F8_type_C 104 karyvrltptswnggn 119
                    +ryv+l+ +s  g+n
    EFC38854.1 251 ITRYVKLEFLSHYGEN 266
                   **********944443 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.1
                   T..SSEEEEEEEEEESSSS.SEEEEEEECEEESSSSSSSEEEEEE CS
  F5_F8_type_C  59 g..nayvksykiqvsddge.tWttvkdekvpgnsdnstpvtntfd 100
                   g   ++v+ +++   ++g+ ++++++ +k p  +d+++++++ +d
    EFC38854.1 480 GvcQYRVTYFSLKCITNGTlKFENIQPTKKPSAKDSKKKQKVVVD 524
                   345788999999999998669999999777777776666666655 PP

>> Fur_reg_FbpB  Fur-regulated basic protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   1.6      0.01        37       2      20 ..     321     339 ..     321     359 .. 0.83
   2 ?    6.7   0.1    0.0014       5.1       7      22 ..     603     618 ..     597     620 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.01
  Fur_reg_FbpB   2 KrkklsFeeLVeeNKkeLl 20 
                   K+   ++ eL++eN +++ 
    EFC38854.1 321 KKEEANLNELIKENTEQIA 339
                   56667899*********96 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0014
  Fur_reg_FbpB   7 sFeeLVeeNKkeLlnD 22 
                   sF  L ++N+++++nD
    EFC38854.1 603 SFISLTQKNREQIIND 618
                   788899*********9 PP

>> T6PP_N  Trehalose-6-phosphate phosphatase N-terminal helical bundle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   3.7    0.0032        11      31      77 ..     277     328 ..     273     373 .. 0.82
   2 ?   -2.7   0.0       1.5   5.5e+03      61      77 ..     515     531 ..     460     533 .. 0.66
   3 ?    6.9   0.6    0.0015       5.4      16      54 ..     547     585 ..     536     619 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0032
      T6PP_N  31 ehfvesLknakesLeadcetgtevlelrtt.....eeekvrldikdEieeLe 77 
                  h ++ L++ k+sL++++++++e  +++++     ++ +++ dik+E  +L+
  EFC38854.1 277 VHGSTLLEDLKKSLQKSSKKNSESTQITNEqtqsnNHGSIEYDIKKEEANLN 328
                 5778899*********99988888888888888999999******9976664 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.5
      T6PP_N  61 eeekvrldikdEieeLe 77 
                 +++k ++ ++dE+++L+
  EFC38854.1 515 SKKKQKVVVDDETDGLD 531
                 46777777788888876 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0015
      T6PP_N  16 RrqIvervLkgieirehfvesLknakesLeadcetgtev 54 
                  ++I +++ + i+i+ +  ++Lkn  ++Le ++ ++ + 
  EFC38854.1 547 KQNILKSLFNAIKIHGENENILKNQIKALEMKNAKTFQY 585
                 678999************************555443333 PP

>> Ac76  Orf76 (Ac76)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.5   6.8e-05      0.24      13      59 ..      28      74 ..      26      84 .. 0.89
   2 ?   -3.4   0.1       2.7   9.8e+03      47      57 ..     295     305 ..     274     310 .. 0.60
   3 ?    1.3   1.1     0.097   3.5e+02      47      82 ..     333     368 ..     326     369 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 6.8e-05
        Ac76 13 lafildkneklsellltllllfvlFiillnvyyikteStpadlytek 59
                l+ + d+ ++ls  + t ++ f++F++++ +y  +  S++ +l+ + 
  EFC38854.1 28 LSELSDTSSQLSRTITTPIISFLVFVLIILIYLDNSSSSTYNLFVHA 74
                56677889999999**************************9998776 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.7
        Ac76  47 kteStpadlyt 57 
                 k++S+++++ +
  EFC38854.1 295 KKNSESTQITN 305
                 34444445555 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.097
        Ac76  47 kteStpadlytekakkikKkrdledafDailNKNtS 82 
                 ++  + a +++++  + k+  +le+ f  +lN   S
  EFC38854.1 333 ENTEQIASIHNSDKENSKRLDQLEESFGKLLNDDIS 368
                 44456788999999999999************8655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (624 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2826  (0.157622); expected 358.6 (0.02)
Passed bias filter:                      572  (0.0319036); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.83u 0.36s 00:00:01.19 Elapsed: 00:00:00.52
# Mc/sec: 3633.09
//
Query:       EFC38855.1  [L=102]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-25   87.0   0.0    1.7e-05   24.5   0.0    4.1  4  LRR_6       Leucine Rich repeat
    8.4e-12   45.1   1.1    1.2e-05   25.5   0.0    2.8  3  LRR_4       Leucine Rich repeats (2 copies)
    2.4e-11   43.2   4.2    4.6e-08   32.7   0.5    2.1  2  LRR_8       Leucine rich repeat
    2.1e-07   30.5   0.0        2.2    9.2   0.0    4.1  4  LRR_1       Leucine Rich Repeat
  ------ inclusion threshold ------
      0.028   14.4   2.7         12    6.0   0.2    3.2  3  ApoB100_C   Apolipoprotein B100 C terminal
      0.069   13.2   0.8          5    7.2   0.1    2.5  2  Spidroin_N  Major ampullate spidroin 1, spider silk protein 1
      0.085   13.0   0.2       0.53   10.4   0.1    1.9  2  NKWYS       Putative capsular polysaccharide synthesis protei


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   8.6e-08   0.00022       4      23 ..       3      22 ..       1      23 [. 0.91
   2 !   17.7   0.0     1e-06    0.0026       5      24 .]      28      47 ..      25      47 .. 0.92
   3 !   24.5   0.0   6.8e-09   1.7e-05       5      24 .]      52      71 ..      49      71 .. 0.92
   4 !   19.2   0.0   3.2e-07   0.00081       5      24 .]      76      95 ..      73      95 .. 0.89

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 8.6e-08
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                 Lt+Ld+s+N+Ig +G++ +
  EFC38855.1  3 RLTSLDISFNQIGVQGVKFI 22
                69***************977 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 1e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+Ld+s+N+ +DeGa+ ++
  EFC38855.1 28 LTSLDISFNQASDEGAKYIS 47
                9***************9885 PP

  == domain 3  score: 24.5 bits;  conditional E-value: 6.8e-09
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L+++ N+IgDeGa+ ++
  EFC38855.1 52 LTSLNITNNEIGDEGAKYIS 71
                9***************9885 PP

  == domain 4  score: 19.2 bits;  conditional E-value: 3.2e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                L +L +s N+IgDeGa+ ++
  EFC38855.1 76 LISLIISRNQIGDEGAKYIS 95
                66899***********9885 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.5   0.0   4.8e-09   1.2e-05       1      35 [.       2      37 ..       2      46 .. 0.85
   2 !   10.7   0.1   0.00022      0.56      21      38 ..      48      64 ..      39      66 .. 0.79
   3 !    6.0   0.0    0.0067        17       1      16 [.      74      89 ..      74     100 .. 0.82

  Alignments for each domain:
  == domain 1  score: 25.5 bits;  conditional E-value: 4.8e-09
                SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-- CS
       LRR_4  1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnl 35
                ++L++Ld+s Nq+   +  + + +++L++Ld+s+N +
  EFC38855.1  2 KRLTSLDISFNQIGVQGVkFISeMKQLTSLDISFN-Q 37
                68**********99777795555*********998.4 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00022
                H-TT--EEE-.-S----- CS
       LRR_4 21 klpnLkeLdLsgNnlitd 38
                 +++L++L++  Nn i+d
  EFC38855.1 48 EMKQLTSLNI-TNNEIGD 64
                399*******.6668865 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0067
                SS--EEE--SS---E- CS
       LRR_4  1 pnLevLdLsnNqltdi 16
                ++L++L +s Nq+ d 
  EFC38855.1 74 KQLISLIISRNQIGDE 89
                589**********985 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   0.5   1.8e-11   4.6e-08       2      61 .]       3      62 ..       2      62 .. 0.98
   2 !   17.8   0.2     8e-07    0.0021       2      37 ..      51      86 ..      50      88 .. 0.94

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 1.8e-11
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +LtsLd+s+N++ + + ++ + +++L++Ld+s N+ +   ++ +s +++L+sL++++N +
  EFC38855.1  3 RLTSLDISFNQIGVQGVKFISEMKQLTSLDISFNQASDEGAKYISEMKQLTSLNITNNEI 62
                8*********************************************************87 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 8e-07
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNll 37
                +LtsL+++nN + + + +  + +++L +L +s+N++
  EFC38855.1 51 QLTSLNITNNEIGDEGAKYISEMKQLISLIISRNQI 86
                79********************************98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0032       8.1       1      13 [.       3      15 ..       3      24 .. 0.81
   2 ?    5.2   0.0     0.018        45       1      11 [.      27      37 ..      27      48 .. 0.84
   3 !    9.2   0.0   0.00085       2.2       1      21 [.      51      71 ..      51      73 .. 0.83
   4 ?    4.1   0.0     0.039        99       2      21 ..      76      95 ..      75      97 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0032
       LRR_1  1 nLrhLdLsnnpll 13
                +L++Ld+s n+++
  EFC38855.1  3 RLTSLDISFNQIG 15
                69********984 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.018
       LRR_1  1 nLrhLdLsnnp 11
                +L++Ld+s n+
  EFC38855.1 27 QLTSLDISFNQ 37
                599******97 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00085
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L++L+++nn +++ ++ +++
  EFC38855.1 51 QLTSLNITNNEIGDEGAKYIS 71
                599********9888877665 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.039
       LRR_1  2 LrhLdLsnnpllglppnsfq 21
                L +L +s+n++++ ++ +++
  EFC38855.1 76 LISLIISRNQIGDEGAKYIS 95
                899*******9888877665 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1     0.029        74      19      32 ..      20      33 ..       8      37 .. 0.86
   2 ?    4.7   0.1     0.011        29      11      34 ..      36      59 ..      32      62 .. 0.87
   3 ?    6.0   0.2    0.0045        12      18      33 ..      67      82 ..      58      97 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.029
   ApoB100_C 19 kliaeskrLiDLsI 32
                k+i+e k+L  L I
  EFC38855.1 20 KFISEMKQLTSLDI 33
                9********98877 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.011
   ApoB100_C 11 dqlsdyyEkliaeskrLiDLsIek 34
                +q sd   k i+e k+L  L I +
  EFC38855.1 36 NQASDEGAKYISEMKQLTSLNITN 59
                68888899**********999976 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0045
   ApoB100_C 18 EkliaeskrLiDLsIe 33
                 k i+e k+Li L I 
  EFC38855.1 67 AKYISEMKQLISLIIS 82
                599**********996 PP

>> Spidroin_N  Major ampullate spidroin 1, spider silk protein 1, N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.012        32      99     118 ..      12      31 ..       4      41 .. 0.82
   2 ?    7.2   0.1     0.002         5      99     121 ..      60      82 ..      35      86 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.012
                 HHTSS--HHHHHHHHHHHHH CS
  Spidroin_N  99 qttGsvnkqfineiksLikm 118
                 + +G++  +fi+e+k+L ++
  EFC38855.1  12 NQIGVQGVKFISEMKQLTSL 31 
                 4589************9876 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.002
                 HHTSS--HHHHHHHHHHHHHHHH CS
  Spidroin_N  99 qttGsvnkqfineiksLikmlaq 121
                 + +G +  ++i+e+k+Li+++ +
  EFC38855.1  60 NEIGDEGAKYISEMKQLISLIIS 82 
                 5689999************9866 PP

>> NKWYS  Putative capsular polysaccharide synthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.09   2.3e+02      37      58 ..      21      41 ..       2      50 .. 0.74
   2 ?   10.4   0.1   0.00021      0.53      39      88 ..      47      97 ..      25     100 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.09
       NKWYS 37 FDnElkknlgiDvfnkdfdkde 58
                F  E+k+++++D+  ++  + e
  EFC38855.1 21 FISEMKQLTSLDISFNQASD-E 41
                66799999999995544433.3 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00021
       NKWYS 39 nElkknlgiDvfnkdfdkdegfvifnnkkf.sllliksekldeldkeikdf 88
                 E+k+++++++ n+++ ++   +i + k+  sl++ + ++ de  k+i ++
  EFC38855.1 47 SEMKQLTSLNITNNEIGDEGAKYISEMKQLiSLIISRNQIGDEGAKYISEM 97
                69**************99888888887765156666666667779998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (102 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       609  (0.0339673); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 676.28
//
Query:       EFC38856.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.012   15.2   0.1      0.017   14.7   0.1    1.3  1  m04gp34like  Immune evasion protein
      0.045   13.6   0.2      0.083   12.7   0.2    1.4  1  DUF3117      Protein of unknown function (DUF3117)
      0.072   13.2   1.1       0.13   12.4   1.1    1.4  1  DUF5367      Family of unknown function (DUF5367)
        1.9    8.6   6.0        4.7    7.4   6.0    1.6  1  Insulin_TMD  Insulin receptor trans-membrane segment


Domain annotation for each model (and alignments):
>> m04gp34like  Immune evasion protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.1   3.7e-06     0.017     212     263 ..     214     265 ..     172     271 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 3.7e-06
                  XXX.XXXXXXX.XXX......XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  m04gp34like 212 vaydyasetkredvsdnrallvtilsvivvllivvvllvLaylYgpsllrrl 263
                  ++y+ ++e+++ +  ++  +l++++ viv+lli+ v +v ++ ++++l ++ 
   EFC38856.1 214 DEYEITVEENPYQFVNEAIVLLLVILVIVSLLILCVGIVSFVFFYKKLNKQN 265
                  789999999999999889999******************9999999998865 PP

>> DUF3117  Protein of unknown function (DUF3117)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2   1.9e-05     0.083      26      48 ..      77      99 ..      72     101 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.9e-05
     DUF3117 26 eGGGRLVvelnkeEaaeLgealk 48
                +G GRL+v+ln+eE ++ +e+l 
  EFC38856.1 77 DGVGRLIVNLNEEEFTNGNELLL 99
                99************999888775 PP

>> DUF5367  Family of unknown function (DUF5367)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.1   2.8e-05      0.13       2      40 ..     227     267 ..     226     269 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.8e-05
     DUF5367   2 fedeatllllvlfllv..iplllvlllpvykykklnkterl 40 
                 f +ea +lllv+ ++v  ++l++ ++++v+ ykklnk++++
  EFC38856.1 227 FVNEAIVLLLVILVIVslLILCVGIVSFVFFYKKLNKQNGM 267
                 55666677666666651145566688999*********987 PP

>> Insulin_TMD  Insulin receptor trans-membrane segment
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   6.0    0.0011       4.7      14      42 ..     232     260 ..     225     263 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0011
  Insulin_TMD  14 ivkIvigPviciillllvigavfvvvkKr 42 
                  iv   +  vi+++l+l v+ + fv++ K+
   EFC38856.1 232 IVLLLVILVIVSLLILCVGIVSFVFFYKK 260
                  555555669999**************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       996  (0.0555525); expected 358.6 (0.02)
Passed bias filter:                      659  (0.0367561); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1667.67
//
Query:       EFC38857.1  [L=634]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.4e-50  169.7  32.1    1.5e-49  168.8  32.1    1.3  1  Aa_trans       Transmembrane amino acid transporter protein
  ------ inclusion threshold ------
      0.057   12.9   0.2      0.057   12.9   0.2    4.4  4  DUF1129        Protein of unknown function (DUF1129)
        1.2    9.0   4.5         15    5.5   0.0    3.1  4  SLATT_1        SMODS and SLOG-associating 2TM effector domain
        1.6    9.1   5.4        2.2    8.6   0.1    3.4  3  Orf78          Orf78 (ac78)


Domain annotation for each model (and alignments):
>> Aa_trans  Transmembrane amino acid transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.8  32.1   3.3e-53   1.5e-49       2     371 ..     173     545 ..     172     548 .. 0.92

  Alignments for each domain:
  == domain 1  score: 168.8 bits;  conditional E-value: 3.3e-53
    Aa_trans   2 tssalsavlnlikaivGaGvLaLPyAfkqlGlivGlillllvallslytlllLvkcsktlasgkrnksYgdlgyrllGpkgkliidlailvqlfGvgvs 100
                 +++++ +v+nli+ + + G+L+++   +q G++ +lil+++++l++l+tl++L ++++++     + s  +l + ++G+ g++i +  il+++fG +++
  EFC38857.1 173 KTGIFLSVFNLINDVLSPGTLSMSQMTAQSGIFSSLILTVFFGLVTLFTLMILYELRRKYL----KTSLLELSELAFGKPGVVIASIPILLFNFGGALG 267
                 5677889**************************************************9874....6777888888************************ PP

    Aa_trans 101 yliligdllpaifesffdt.........lllsnvyfilisaliiipLslipnlskLsylSllalvsslyyivilvlvvaelvklelkgvseetvkkask 190
                   i++g l+p ++  + ++          l+s+ ++ +i ++i+ip++l +nl ++ ++S+++++s+l   ++++   +e+++++   + ++ +  ++ 
  EFC38857.1 268 MFIMFGHLVPDLLLLVEKNfssilsgysFLFSRESVLIILTIIMIPFALRKNLGSYAITSFISVSSVL---LVGIWLAIEKMTGQRALIPSSNA-FDFA 362
                 **********988776666777999998899************************************7...47888888889999999999998.8999 PP

    Aa_trans 191 lkglflaigiivFAftghavlleiqnelkdpskfkkmtkvlllsiilatvlyilvGlvGYltFGnevkg..nillnlpkssilivivnlllvlhlilsf 287
                 ++++++a+g ++F +++h +++ i  +l+ p  f  ++ v l+++i+++++ ++vG++GYl+F+++  +  n+l+ +p+++ + +i+++++ l++i+s+
  EFC38857.1 363 KSEILSAFGALAFIYVCHDIVFHIFSNLRRPTRFR-FFLVALFVVIITILTITCVGMSGYLIFYDKCLDdaNVLNLFPFNDPMAIIARIIISLNIIMSI 460
                 9********************************99.88899999999999999***************999**************************** PP

    Aa_trans 288 plqlhplrqvvenllikk.eavagasekeapkskllrlvirlllvvityliAlsvpslakvlslvGatsstplsfilPalfhlkl 371
                 p +l+  r+ +++ll+++  +v +  +k +  ++ l++++++ +++++  +A+ v+ l+ v +l+Ga+++++l++i+P+ ++lkl
  EFC38857.1 461 PYALFMPRDCLHTLLKTIlPKVYKRIQKTKVRRNILHVILTMTVLLTSFGVAIGVTDLGIVADLFGAVAASSLAYIIPPSLYLKL 545
                 ***************99843444444555555566788999999999999*********************************97 PP

>> DUF1129  Protein of unknown function (DUF1129)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.2   1.3e-05     0.057      63     145 ..     152     236 ..     143     259 .. 0.80
   2 ?    0.9   2.0      0.06   2.7e+02     118     169 ..     366     418 ..     326     423 .. 0.67
   3 ?    1.2   0.2      0.05   2.2e+02     133     170 ..     482     520 ..     471     537 .. 0.74
   4 ?    6.0   0.1    0.0016       7.3     137     174 ..     591     629 ..     581     633 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.3e-05
     DUF1129  63 lekkkkakkeskenpwlmalDnsLlllalfallfgil..alfskkkqtasiGlitlllvalvgGlamvlvyrlltrekkkkkrpp 145
                 + ++kk+kk+ k++ +l+   ++ ++l++f+l++ +l  + +s +++ta++G+ + l++++ +Gl+ +++  +l++  +k  +++
  EFC38857.1 152 KVPEKKEKKNGKRKRSLIYDKKTGIFLSVFNLINDVLspGTLSMSQMTAQSGIFSSLILTVFFGLVTLFTLMILYELRRKYLKTS 236
                 5566666777765566666567789***********94458999999999********************999997666655555 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.06
     DUF1129 118 lvalvgGlamvlvyrlltre.kkkkkrpplwkrllilllllvvwlvlftlval 169
                 ++++ g la+++v + +  +  ++ +rp  ++ +l++l+++++ ++ +t v++
  EFC38857.1 366 ILSAFGALAFIYVCHDIVFHiFSNLRRPTRFRFFLVALFVVIITILTITCVGM 418
                 56666777777777666666466666666666666666666666666666655 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.05
     DUF1129 133 lltrekkkkkrpplwkrllilllllvvwlvlftlval.l 170
                 + +r +k+k r+++++++l +++ll ++ v++ ++ l +
  EFC38857.1 482 VYKRIQKTKVRRNILHVILTMTVLLTSFGVAIGVTDLgI 520
                 333336788899999999999999999888888877655 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.0016
     DUF1129 137 e.kkkkkrpplwkrllilllllvvwlvlftlvallpavi 174
                 + ++++ r++l+++l+ ++ ++v++l +f+lv+ +++vi
  EFC38857.1 591 DaHSNSLRQQLFRILIGVTCMMVLLLGIFILVGTITSVI 629
                 2488999**************************999987 PP

>> SLATT_1  SMODS and SLOG-associating 2TM effector domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0       2.5   1.1e+04      83      97 ..      99     113 ..      93     125 .. 0.75
   2 ?   -3.2   0.2       1.7   7.6e+03      30      71 ..     303     343 ..     301     350 .. 0.58
   3 ?    3.9   0.1      0.01        46      24      69 ..     490     536 ..     481     538 .. 0.58
   4 ?    5.5   0.0    0.0034        15      11      51 ..     583     623 ..     577     632 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.5
     SLATT_1  83 laaeeLeiiraalea 97 
                  ++eeL i++++ ++
  EFC38857.1  99 VIEEELRIVSTWSQQ 113
                 578899999999886 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.7
     SLATT_1  30 llillellalllaalrafgelsv.dlvgvlaavaaallaWlel 71 
                 +li+l+++ + +a+ + +g++ + +++ v +++   +  Wl++
  EFC38857.1 303 VLIILTIIMIPFALRKNLGSYAItSFISVSSVLL--VGIWLAI 343
                 5677777777777777777776644444443333..3345555 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.01
     SLATT_1  24 akrwrlllillellalllaalr.afgelsv.dlvgvlaavaaallaWl 69 
                 + r ++l ++l++  +ll+ ++ a+g++++  +++++ avaa+ la++
  EFC38857.1 490 KVRRNILHVILTM-TVLLTSFGvAIGVTDLgIVADLFGAVAASSLAYI 536
                 2223333333333.33333444366677776699*********99986 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.0034
     SLATT_1  11 dwYrkkaeeneraakrwrlllillellalllaalrafgels 51 
                 ++Y+kk++  ++++ r +l  il++++ +++ +l++f  ++
  EFC38857.1 583 EYYAKKSNDAHSNSLRQQLFRILIGVTCMMVLLLGIFILVG 623
                 6*************999999999999999999988554433 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.34   1.5e+03      62      79 ..     208     225 ..     152     232 .. 0.75
   2 ?   -0.8   1.0      0.43   1.9e+03      64      85 ..     404     425 ..     394     432 .. 0.76
   3 ?    8.6   0.1    0.0005       2.2      28      85 ..     563     620 ..     547     626 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.34
       Orf78  62 alnillisllavvcvlvl 79 
                     ++++l++++++++l
  EFC38857.1 208 LILTVFFGLVTLFTLMIL 225
                 344566677777776665 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.43
       Orf78  64 nillisllavvcvlvllyviyY 85 
                  +++i++l++ cv +  y+i+Y
  EFC38857.1 404 FVVIITILTITCVGMSGYLIFY 425
                 4677777777777777788887 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0005
       Orf78  28 nddndkaenkkekksaaeknditekesnaaekaqalnillisllavvcvlvllyviyY 85 
                  +++++ ++++++   ++ ++  +k+sn+a++++  + l+  l+ v c++vll  i+ 
  EFC38857.1 563 LSNTKSVTETNNTIIEHPLEEYYAKKSNDAHSNSLRQQLFRILIGVTCMMVLLLGIFI 620
                 344444445555555556666666677788999999999999**********988764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (634 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1277  (0.0712254); expected 358.6 (0.02)
Passed bias filter:                      541  (0.0301746); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.74u 0.35s 00:00:01.08 Elapsed: 00:00:00.51
# Mc/sec: 3755.74
//
Query:       EFC38858.1  [L=457]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.9e-28   95.8  19.5    2.1e-06   28.3   0.2    7.7  8  WD40         WD domain, G-beta repeat
    1.7e-14   53.9   2.0     0.0073   16.6   0.0    4.4  5  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
      6e-09   35.7   2.7       0.19   11.0   0.0    4.3  4  WD40_like    WD40-like domain
    1.1e-05   24.6   1.1      0.053   12.5   0.1    2.7  3  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
     0.0014   17.3   1.1        1.3    7.6   0.1    2.8  3  Nup160       Nucleoporin Nup120/160
  ------ inclusion threshold ------
       0.13   11.9   0.1       0.29   10.8   0.1    1.5  1  TGBp3        Triple gene block 3
       0.15   11.9   1.4       0.71    9.8   0.1    2.5  2  PKD          PKD domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.5   0.2    0.0031       7.9       6      37 ..      87     122 ..      76     123 .. 0.79
   2 !   20.8   0.0     2e-07    0.0005       3      38 .]     133     169 ..     131     169 .. 0.89
   3 !    9.5   0.6   0.00076       1.9       4      38 .]     176     211 ..     173     211 .. 0.87
   4 !   28.3   0.2   8.3e-10   2.1e-06       2      38 .]     216     253 ..     215     253 .. 0.91
   5 !    6.7   0.0    0.0059        15       2      34 ..     258     300 ..     257     302 .. 0.68
   6 !   21.0   0.0   1.7e-07   0.00045       8      38 .]     318     350 ..     308     350 .. 0.82
   7 ?   -2.1   0.1       3.4   8.6e+03      12      29 ..     389     407 ..     379     416 .. 0.59
   8 !   10.2   0.0   0.00045       1.1       2      38 .]     421     456 ..     420     456 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0031
                 EEESS.SSEEEEE..EETTSSEEE.EEETTSEEEEE CS
        WD40   6 tltGH.ssvtsla..fspdgawla.sGsdDgtvriW 37 
                 ++  H + ++s++  ++ + ++++ ++s D + ++W
  EFC38858.1  87 SFNEHtDAIYSISviNDGNDKFICaTSSGDDSAYLW 122
                 67789555999998899999998535555*999999 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 2e-07
                 EEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 ++ +l GH + v   +f+ d++ la++ +Dgtv++W+
  EFC38858.1 133 PIAKLAGHtDTVLQSKFNFDKTILATAAMDGTVKLWN 169
                 677899**66699999**********999*******8 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.00076
                 EEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   4 lrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 + +l+G  +s+  ++++p g+ ++ Gs D t  +W+
  EFC38858.1 176 ISSLEGPgDSIEWIDWHPRGNIIIGGSQDATTWMWN 211
                 5678888777999***********999****99998 PP

  == domain 4  score: 28.3 bits;  conditional E-value: 8.3e-10
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                  cl +++GH  svt  +f  dg++++++sdD tv+iW+
  EFC38858.1 216 VCLNVFSGHsESVTNGCFTTDGKLMVTASDDATVKIWN 253
                 699******777*7777********************8 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.0059
                 EEEEEEESS.SS........EEEEEEETTSSE.EEEEETTSEE CS
        WD40   2 qclrtltGH.ss........vtslafspdgaw.lasGsdDgtv 34 
                 +c+  +++H ++        +tsl+ s  ++  +++Gs Dg++
  EFC38858.1 258 ECIVNYSAHeKNiksfceepITSLKCSTLNPSvFLCGSLDGSI 300
                 688899999977455666667777644444443358*****98 PP

  == domain 6  score: 21.0 bits;  conditional E-value: 1.7e-07
                 ESS.SSEEEEEEETTSSEE.EEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgawl.asGsdDgtvriWd 38 
                  +H +sv  + f+p+++ l +s+++Dg + +Wd
  EFC38858.1 318 HAHtNSVEEVLFHPENQSLlVSCGMDGQIVVWD 350
                 389999************7359999*******9 PP

  == domain 7  score: -2.1 bits;  conditional E-value: 3.4
                 SEEEEEEETTSSEEE.EEE CS
        WD40  12 svtslafspdgawla.sGs 29 
                 +vt   f++ +++++ sG+
  EFC38858.1 389 GVTRAFFDSTQSYIIySGD 407
                 3655558888888655775 PP

  == domain 8  score: 10.2 bits;  conditional E-value: 0.00045
                 EEEEEEESSSS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGHss.vtslafspdgawlasGsdDgtvriWd 38 
                 + l+ + GH + v++l  s+++++++s s+D+   i++
  EFC38858.1 421 KVLKLYQGHADvVSDL--SQSSKYIFSTSEDKRALIFN 456
                 6678899**7757***..********99***9988876 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   5.2e-06     0.013      37      90 ..     140     192 ..     121     194 .. 0.87
   2 !    6.8   0.1    0.0033       8.5      37      82 ..     182     227 ..     179     230 .. 0.88
   3 !   16.3   0.1   3.4e-06    0.0087      36      84 ..     223     270 ..     210     285 .. 0.87
   4 !   16.6   0.0   2.9e-06    0.0073      15      71 ..     296     355 ..     290     365 .. 0.87
   5 ?   -2.9   0.0       3.3   8.5e+03      60      81 ..     410     431 ..     402     437 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 5.2e-06
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgWg 90 
                  +  +v + +++ d ++La a  dg+v+l +a+sg  ++sl+   + ++  ++W 
   EFC38858.1 140 HTDTVLQSKFNFDKTILATAAMDGTVKLWNAKSGAFISSLEGPGD-SIEWIDWH 192
                  5667888899******************************87776.59999885 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0033
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksek 82 
                  ++ +++ + W+p g+++  + +d +  + + +++ +++ +s +se+
   EFC38858.1 182 PGDSIEWIDWHPRGNIIIGGSQDATTWMWNTQKEVCLNVFSGHSES 227
                  5778999***********************9999999999888774 PP

  == domain 3  score: 16.3 bits;  conditional E-value: 3.4e-06
  ANAPC4_WD40  36 kedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekav 84 
                  +++++v++ ++  dgkl++ a +d +v++ + ++++++ ++s+++++ +
   EFC38858.1 223 GHSESVTNGCFTTDGKLMVTASDDATVKIWNPKTAECIVNYSAHEKN-I 270
                  478899999**********************************9986.4 PP

  == domain 4  score: 16.6 bits;  conditional E-value: 2.9e-06
  ANAPC4_WD40  15 edgellvfRlngqrvwtl..eedkedsevrsLaWkpdgklLavays.dgevrlldaesgk 71 
                   dg+++++ l+ qrv +   +++++ ++v+++ ++p+++ L v++  dg++ + d + g 
   EFC38858.1 296 LDGSIALCQLEQQRVISHlkNKHAHTNSVEEVLFHPENQSLLVSCGmDGQIVVWDTNAGS 355
                  689**************998889999**********999999988549*****9998886 PP

  == domain 5  score: -2.9 bits;  conditional E-value: 3.3
  ANAPC4_WD40  60 gevrlldaesgkvvhslsvkse 81 
                  g++   d+ +gkv++ ++ +++
   EFC38858.1 410 GNILSWDIRTGKVLKLYQGHAD 431
                  6677788888998888877665 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.1    0.0031       8.1       3      69 ..      95     169 ..      93     180 .. 0.72
   2 !    9.4   0.0   0.00023      0.58       6      65 ..     189     248 ..     184     276 .. 0.78
   3 !   11.0   0.0   7.3e-05      0.19      48      82 ..     283     317 ..     255     363 .. 0.78
   4 !    6.9   0.1    0.0013       3.4     244     291 ..     397     444 ..     375     449 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0031
   WD40_like   3 iYsidiskkgs...lilyGgkddkctvlkleslesvsi....vesfedSvifvklldddlilv.vtlDGtillsl 69 
                 iYsi + ++g+   + +  + dd + + ++++ ++ ++    +++ +d v+ +k+  d+ il  +++DGt+ l  
  EFC38858.1  95 IYSISVINDGNdkfICATSSGDDSAYLWTFDTTTMTTSpiakLAGHTDTVLQSKFNFDKTILAtAAMDGTVKLWN 169
                 8999887666433234567889999999999887654332227889*********999988852789***96554 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00023
   WD40_like   6 idiskkgslilyGgkddkctvlkleslesvsivesfedSvifvklldddlilvvtlDGti 65 
                 id  ++g++i+ G++d +  + +++ +    ++ + ++Sv    +  d +++v++ D + 
  EFC38858.1 189 IDWHPRGNIIIGGSQDATTWMWNTQKEVCLNVFSGHSESVTNGCFTTDGKLMVTASDDAT 248
                 89999*****9999999999**********************999999888887766544 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 7.3e-05
   WD40_like  48 vklldddlilvvtlDGtillslleneeevenekie 82 
                 +  l+  ++l+++lDG i l++le++ ++++ k +
  EFC38858.1 283 CSTLNPSVFLCGSLDGSIALCQLEQQRVISHLKNK 317
                 7789999*******************988876654 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0013
   WD40_like 244 kisefvvafsTlcgkvgigDiRdketfkllesgvGviydmkfenntiy 291
                 + ++++++   + g + + DiR ++ +kl++++  v+ d+   + +i+
  EFC38858.1 397 STQSYIIYSGDILGNILSWDIRTGKVLKLYQGHADVVSDLSQSSKYIF 444
                 56789999999*****************************99998887 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.1   2.1e-05     0.053     181     215 ..     134     169 ..      95     173 .. 0.88
   2 !   10.0   0.1   0.00012      0.31     180     215 ..     217     253 ..     202     274 .. 0.78
   3 ?   -2.1   0.0      0.57   1.4e+03      65     104 ..     321     360 ..     304     376 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.1e-05
    Ge1_WD40 181 llkieehs.liveaafspdGtalatasedGevkffq 215
                 + k+  h+ ++ ++ f  d t lata++dG+vk++ 
  EFC38858.1 134 IAKLAGHTdTVLQSKFNFDKTILATAAMDGTVKLWN 169
                 5577788779***********************996 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00012
    Ge1_WD40 180 gllkieehs.liveaafspdGtalatasedGevkffq 215
                  l  ++ hs  ++++ f++dG  + tas d +vk + 
  EFC38858.1 217 CLNVFSGHSeSVTNGCFTTDGKLMVTASDDATVKIWN 253
                 33446778878***********************995 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.57
    Ge1_WD40  65 kgevldlafahvsskillavdekgslfvykveeveskllv 104
                 +++v+++ f   +++ l++    g+++v++ ++ + +l+ 
  EFC38858.1 321 TNSVEEVLFHPENQSLLVSCGMDGQIVVWDTNAGSARLVL 360
                 4566666666666666666777777777776666666655 PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0   0.00065       1.7     228     255 ..     149     178 ..     125     206 .. 0.84
   2 !    7.6   0.1    0.0005       1.3     219     254 ..     226     261 ..     209     284 .. 0.87
   3 ?   -1.2   0.0      0.23   5.9e+02     229     276 ..     333     383 ..     284     432 .. 0.66

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00065
                 ...TTTEEEEEETT-EEEEEETTTTEEEEE CS
      Nup160 228 i..gqtylfalsrdgkLrvWnlltgkclat 255
                    ++t+l+++  dg++++Wn ++g  +++
  EFC38858.1 149 FnfDKTILATAAMDGTVKLWNAKSGAFISS 178
                 14499****************999877765 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0005
                 EEEET.....TTTEEEEEETT-EEEEEETTTTEEEE CS
      Nup160 219 ldvavavveigqtylfalsrdgkLrvWnlltgkcla 254
                  +v++++ +++ ++ +++s d ++++Wn +t+ c+ 
  EFC38858.1 226 ESVTNGCFTTDGKLMVTASDDATVKIWNPKTAECIV 261
                 57899999999999******************9985 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.23
                 TTTEEEEEETT-EEEEEETTTTEEEEE.EE--...-SSSTTS--SSEESEE CS
      Nup160 229 gqtylfalsrdgkLrvWnlltgkclat.idll..rdeeaqdessskstldp 276
                 +q++l++   dg + vW+++ g+   + ++ +   + e  ++sss ++ d+
  EFC38858.1 333 NQSLLVSCGMDGQIVVWDTNAGSARLVlKNYPiiENPELGSSSSSDLNFDT 383
                 677777777888888888877777666666666655666666666655544 PP

>> TGBp3  Triple gene block 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1   0.00012      0.29      18      44 ..     208     235 ..     205     242 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00012
       TGBp3  18 llntsssegCvivITGesvtitg.Ceit 44 
                 ++ ++++e C+ v++G+s  +t+ C  t
  EFC38858.1 208 WMWNTQKEVCLNVFSGHSESVTNgCFTT 235
                 33499******************9*444 PP

>> PKD  PKD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   0.00028      0.71      18      46 ..     111     135 ..     107     138 .. 0.81
   2 ?   -0.5   0.2      0.44   1.1e+03      23      47 ..     203     230 ..     199     246 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00028
                 EES.-SS-SEEEEE--SS--EEEEETTEE CS
         PKD  18 aavpdganvtysWdfgdgsvvqvlseptv 46 
                 a++ +g++ +y+W+f+    ++ +++p +
  EFC38858.1 111 ATS-SGDDSAYLWTFDT---TTMTTSPIA 135
                 444.9************...888888865 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.44
                 SS-SEEEEE--SS...--EEEEETTEEE CS
         PKD  23 ganvtysWdfgdg...svvqvlseptvt 47 
                  + +t+ W+++ +    v    se+ ++
  EFC38858.1 203 QDATTWMWNTQKEvclNVFSGHSESVTN 230
                 5778999*99998775444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (457 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       478  (0.0266607); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 3020.57
//
Query:       EFC38859.1  [L=364]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (364 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.40u 0.25s 00:00:00.65 Elapsed: 00:00:00.40
# Mc/sec: 2697.47
//
Query:       EFC38860.1  [L=320]
Description: Hypothetical protein NAEGRDRAFT_73417 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      0.001   18.9   0.6     0.0022   17.9   0.6    1.5  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.6   1.2e-07    0.0022       9      36 ..      17      44 ..      14      47 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 1.2e-07
  F-box-like  9 LlqIFsyLppsdLlrlalVCrrWrrval 36
                L ++Fs+ ++ d ++++l+Cr+W++v++
  EFC38860.1 17 LTEVFSFCSLFDFYSISLTCRDWCEVVS 44
                7789**99999***************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 2080.65
//
Query:       EFC38861.1  [L=212]
Description: rab family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.1e-61  205.0   0.1      6e-61  204.8   0.1    1.1  1  Ras          Ras family
    1.7e-32  112.2   0.0    2.7e-32  111.5   0.0    1.3  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    2.2e-13   50.0   0.0    2.7e-13   49.7   0.0    1.1  1  Arf          ADP-ribosylation factor family
    4.2e-05   23.6   0.0    7.8e-05   22.7   0.0    1.4  1  MMR_HSR1     50S ribosome-binding GTPase
    4.3e-05   23.1   0.1     0.0016   18.0   0.1    2.2  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    0.00038   19.9   0.0    0.00048   19.6   0.0    1.2  1  Gtr1_RagA    Gtr1/RagA G protein conserved region
     0.0013   18.6   0.1        1.1    9.2   0.0    2.3  2  RsgA_GTPase  RsgA GTPase
      0.006   16.4   0.0       0.17   11.6   0.0    2.0  2  ATP_bind_1   Conserved hypothetical ATP binding protein
  ------ inclusion threshold ------
      0.023   14.1   0.0      0.067   12.6   0.0    1.6  2  SRPRB        Signal recognition particle receptor beta subuni
      0.026   14.8   0.1      0.073   13.3   0.0    2.0  1  AAA_22       AAA domain
      0.098   12.9   0.0       0.18   12.1   0.0    1.3  1  TetR_C_16    Tetracyclin repressor-like, C-terminal domain
        0.1   12.5   0.0       0.19   11.6   0.0    1.4  1  NACHT        NACHT domain
       0.12   12.7   0.0       0.16   12.3   0.0    1.2  1  DUF1863      MTH538 TIR-like domain (DUF1863)
       0.19   12.1   0.0       0.28   11.6   0.0    1.4  1  AAA_16       AAA ATPase domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  204.8   0.1   4.7e-64     6e-61       1     161 [.       9     169 ..       9     170 .. 0.99

  Alignments for each domain:
  == domain 1  score: 204.8 bits;  conditional E-value: 4.7e-64
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K +++Gd +vGK++ll++f+++kF+++  +Tigv+f t+ iev+gk++kl+iwDTAGqe+f++++++yyr+a g+l+vydit+r++f+++++w+++ ++
  EFC38861.1   9 KYIIIGDMGVGKSCLLHQFTEQKFQSDCPHTIGVEFGTRVIEVEGKSIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRNTFHHLASWLTDARN 107
                 89************************************************************************************************* PP

                 HSTTTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHHHHHHHHHHHH CS
         Ras 100 vaeenvpivLvGnKvDleekravsteegeelakelglkfletSAktnenveeafeellreil 161
                  ++ ++ ivL+GnK+Dle++r+vs+ee++++ake+gl ++etSAkt env++af+e +++i+
  EFC38861.1 108 LTNPHTIIVLIGNKSDLEDQRQVSFEEASRFAKENGLVYVETSAKTGENVTKAFMETASRIY 169
                 ***99***************************************************999886 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.5   0.0   2.1e-35   2.7e-32       1     119 [.       9     123 ..       9     124 .. 0.89

  Alignments for each domain:
  == domain 1  score: 111.5 bits;  conditional E-value: 2.1e-35
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K +++Gd gvGK++ll++f+e+kf+++   tigv+f t+ + +++g       k++kl+iWDtaGqerfr+++++y+r+aa a++vyd   ++++++l 
  EFC38861.1   9 KYIIIGDMGVGKSCLLHQFTEQKFQSDCPHTIGVEFGTRVI-EVEG-------KSIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDitrRNTFHHLA 99 
                 789*********************************99754.5555.......689********************************75444678999 PP

                 HHHHHHHHHCS.SS-EEEEEE-TT CS
         Roc  97 eWlkelkkvag.kspvilvgnkiD 119
                 +Wl++ ++ ++ +++++l+gnk D
  EFC38861.1 100 SWLTDARNLTNpHTIIVLIGNKSD 123
                 ********9773667889****99 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.7   0.0   2.1e-16   2.7e-13      15     165 ..       8     158 ..       1     168 [. 0.74

  Alignments for each domain:
  == domain 1  score: 49.7 bits;  conditional E-value: 2.1e-16
                 EEEEEEESTTSSHHHHHHHHHHSSCEECSS.SS....SEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHHC CS
         Arf  15 lrilllGLDnaGKtTilkklkleelvttvP.Ti....gfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLkall 108
                 ++ +++G  + GK+ +l++++++++++  P Ti    g  v e+e k +k+++wD  Gqe+ R + ++Y++   + + v D + r+ +++  + L+   
  EFC38861.1   8 FKYIIIGDMGVGKSCLLHQFTEQKFQSDCPhTIgvefGTRVIEVEGKSIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRNTFHHLASWLTDAR 106
                 6889999999*****************9996662222456778899****************************************9999988888765 PP

                 TSGCCTTSEEEEEEE-TTSTTSS-HH..HHHHHTTGGGSSSSSSEEEEEEBTTTTBTHH CS
         Arf 109 eeeelkevallvlaNKqDlpealsee..elrellgleelkgkrkleiqkcsavkgeglk 165
                 +  +  + ++++++NK Dl+++ + +  e ++        +++ l  +++sa +ge+++
  EFC38861.1 107 NLTNP-HTIIVLIGNKSDLEDQRQVSfeEASRFA------KENGLVYVETSAKTGENVT 158
                 55444.55666679*****986543200222222......2333444555555555555 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.0   6.1e-08   7.8e-05       3     103 ..      11     104 ..       9     121 .. 0.64

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 6.1e-08
                 EEEESTTSSHHHHHHHHHTS..TEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT.TTCSHHHHHHH CS
    MMR_HSR1   3 aivGrpNvGKStLinaltge..kaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas.eeklkpldeel 97 
                 +i+G   vGKS L+ + t++  ++   ++ g+   ++ ++v+ k  +++++Dt+G  e   + + +++++    + a  +l+v d++ ++++    ++l
  EFC38861.1  11 IIIGDMGVGKSCLLHQFTEQkfQSDCPHTIGVEFGTRVIEVEGKSIKLQIWDTAG-QE---RFRAVTRSYY---RgAAGALMVYDITrRNTF----HHL 98 
                 79*****************94445555666666666666666555899*******.54...2335666666...448899999998832223....445 PP

                 HHHHHH CS
    MMR_HSR1  98 eellee 103
                 +++l++
  EFC38861.1  99 ASWLTD 104
                 555443 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.1   1.3e-06    0.0016      58     183 ..      46     159 ..       5     179 .. 0.73

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1.3e-06
                 CEEEEEETTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB.STHHHHHHHHHHHHTTTE...EEEEEESCGSTHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  58 saaisleketkkylinliDtPGHvdFskevirglrvlDgavlvvdaveG.vepqteevlrlalkegvp...iivfiNKmDrlkaelkeiveevkqklsr 152
                 + +i++e  +k+ ++++ Dt G + F   +   +r + ga++v d+++    +     l  a+++  p   i+++ NK D  +++ + + ee++ ++  
  EFC38861.1  46 TRVIEVE--GKSIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRnTFHHLASWLTDARNLTNPhtiIVLIGNKSDLEDQR-QVSFEEAS-RF-- 138
                 4556677..*****************9988888*************976244555566667777777788455555****87554.44455555.56.. PP

                 HHHHHHHHHHTTTTTEEEEEEBTTTTBTHHH CS
    GTP_EFTU 153 keeklekygekgekevpvvfgSalkgegvkt 183
                        ++e+       v +Sa++ge+v++
  EFC38861.1 139 -------AKEN---GLVYVETSAKTGENVTK 159
                 .......1222...24556666666666664 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   3.7e-07   0.00048       3     139 ..      11     138 ..       9     182 .. 0.76

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 3.7e-07
   Gtr1_RagA   3 LLmGksgsGKtsmrsiiFdnylardt.lrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletlke 100
                 +++G  g GK+++     ++    d+  ++g+   ++  ev   + ++l++wD  Gqe+f + +    +++     g+ + V D++    ++++++l +
  EFC38861.1  11 IIIGDMGVGKSCLLHQFTEQKFQSDCpHTIGVEFGTRVIEV-EGKSIKLQIWDTAGQERFRAVT----RSYYRGAAGA-LMVYDIT---RRNTFHHLAS 100
                 78899999999987766665555555256777777777777.36789*************9987....4444444455.5699***...8899999*** PP

   Gtr1_RagA 101 ilealrqyspeakvfvli.hKmDliqedereeifeerkee 139
                  l+ +r+  +  ++ vli +K Dl   d+r+  fee ++ 
  EFC38861.1 101 WLTDARNLTNPHTIIVLIgNKSDLE--DQRQVSFEEASRF 138
                 *******999999999996799986..7777777776554 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0   0.00084       1.1     103     122 ..      11      30 ..       8      54 .. 0.88
   2 !    7.2   0.0    0.0034       4.4      50      92 ..     114     159 ..      83     170 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.00084
                  EEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase 103 vlvGqSGvGKStLinallpe 122
                  +++G  GvGKS L+ +++++
   EFC38861.1  11 IIIGDMGVGKSCLLHQFTEQ 30 
                  899***********998876 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0034
                  EEEE..E-GGG--HHH.HHHHHHHHHHHTTSEEEE--TTTHTTHHH CS
  RsgA_GTPase  50 vivl..nKiDlleeee.eleelkeelealgyevllvsaktkeglee 92 
                  +ivl  nK Dl ++++ ++ee +   ++ g+  + +sakt+e++++
   EFC38861.1 114 IIVLigNKSDLEDQRQvSFEEASRFAKENGLVYVETSAKTGENVTK 159
                  444445********99899999999***************999876 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0     0.048        61       1      19 [.      12      30 ..      12      40 .. 0.85
   2 !   11.6   0.0   0.00014      0.17      72     229 ..      42     183 ..      29     195 .. 0.65

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.048
  ATP_bind_1  1 vvGpaGsGKttfvgalsei 19
                ++G  G+GK+ + ++++e 
  EFC38861.1 12 IIGDMGVGKSCLLHQFTEQ 30
                79***********999875 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00014
  ATP_bind_1  72 leflresldwldeelekeeddyllfDtPGQielfthseslakiveeLesefalvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllk 170
                 +ef++  +     e+e ++ ++ + Dt GQ ++  +  s          ++a +++++ D +r ++    + + l+  + + + ++  v + nk Dl +
  EFC38861.1  42 VEFGTRVI-----EVEGKSIKLQIWDTAGQERFRAVTRSYY--------RGAAGALMVYDITRRNT-FHHLASWLTDARNLTNPHTIIVLIGNKSDLED 126
                 55555555.....2322334999****************99........9***********99877.6666666999999999999999999*****66 PP

  ATP_bind_1 171 eklekeleffedvealslllekee....ekykklaeaiael.leefalvlrflplssekeesie 229
                  +++  +e  + + + +           e  +k  e++ ++ +e+ +++++ +++ + + +s+e
  EFC38861.1 127 -QRQVSFEEASRFAKEN------GlvyvETSAKTGENVTKAfMETASRIYKNIVDGVLDPNSVE 183
                 .3333333333332222......12223344444555544414444555555666555555555 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   5.2e-05     0.067       6      86 ..      10      90 ..       6     132 .. 0.63
   2 ?   -2.0   0.0       1.6     2e+03      77     104 ..     142     173 ..     126     197 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 5.2e-05
                EEEE-STTSSHHHHHHHHHHSS---B-.--SS-EEETTG...GGT..T-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETT CS
       SRPRB  6 vllvGlsdsGKTslftrLttdsvkktv.tSqessaalkvksekgs..kltliDfPGheklrqklleklkaksslkglvfvvDSt 86
                 +++G +  GK  l+++ t++++++     +  ++ ++v + +g+  kl++ D  G+e++r     +    + + g + v D t
  EFC38861.1 10 YIIIGDMGVGKSCLLHQFTEQKFQSDCpHTIGVEFGTRVIEVEGKsiKLQIWDTAGQERFRAVTRSY---YRGAAGALMVYDIT 90
                59******************98876551555888888885555551166778********9754444...45555555666654 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.6
                 EEEEEEEETTS-HHHHH....HHHHHHHHHHH CS
       SRPRB  77 kglvfvvDStidpkevk....evAEllyeill 104
                  glv+v  S+    +v+    e+A  +y+ ++
  EFC38861.1 142 NGLVYVETSAKTGENVTkafmETASRIYKNIV 173
                 56666666665544443111144444444444 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   5.7e-05     0.073       9      45 ..      11      42 ..       9     147 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 5.7e-05
      AAA_22  9 vvtGesGtGKTtllrrlleqldeeakaeeerpevvfv 45
                +++G  G+GK+ ll +++eq+ +       +p+++ v
  EFC38861.1 11 IIIGDMGVGKSCLLHQFTEQKFQS-----DCPHTIGV 42
                89*****************97332.....35555533 PP

>> TetR_C_16  Tetracyclin repressor-like, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   0.00014      0.18      12      60 ..      58     106 ..      55     117 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00014
                 HHHHHHHT-HHHHHHHHH--------HHHHHHHHHHHHHHCTTTS-STT CS
   TetR_C_16  12 levwepearepllallrsalsseeaaellrefleeqvlaplaarlggpd 60 
                 l+ w+ +++e+++a+ rs     + a ++ +++++  +  la++l++++
  EFC38861.1  58 LQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRNTFHHLASWLTDAR 106
                 567****************999999********************9874 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00015      0.19       4      31 ..      11      38 ..       9      54 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00015
                EEEC-TTTCHHHHHHHHHHHHCTS-SCC CS
       NACHT  4 ilqGeaGsGKTtLlqklalawaegklpq 31
                i+ G+ G+GK+ Ll+++ ++  ++++p+
  EFC38861.1 11 IIIGDMGVGKSCLLHQFTEQKFQSDCPH 38
                899**************99999988887 PP

>> DUF1863  MTH538 TIR-like domain (DUF1863)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   0.00013      0.16      58     122 ..      96     164 ..      59     173 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00013
     DUF1863  58 edikeai..rdaldrssvliVLvgset..atsrWvdwEIaaslkkgkrllgvsldrlkqrdarrrlpta 122
                   + +++  +++l++ +++iVL+g++    ++r v  E a+   k+++l+ v+   + + +  +  +++
  EFC38861.1  96 HHLASWLtdARNLTNPHTIIVLIGNKSdlEDQRQVSFEEASRFAKENGLVYVETSAKTGENVTKAFMET 164
                 678888877789************98755789********************99988877665555554 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00022      0.28      28      76 ..      11      64 ..       9     142 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00022
      AAA_16 28 llsGesGvGKsslvrellralekd............ggiflrgkcdqlesaipysalaqal 76
                +++G+ GvGKs l+ ++ ++  ++            ++i ++gk  +l       ++++++
  EFC38861.1 11 IIIGDMGVGKSCLLHQFTEQKFQSdcphtigvefgtRVIEVEGKSIKL-------QIWDTA 64
                699**************9855555566666555533233355555555.......455555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       743  (0.0414412); expected 358.6 (0.02)
Passed bias filter:                      664  (0.037035); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 1235.91
//
Query:       EFC38862.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00032   20.0   8.4    0.00046   19.5   0.9    2.6  2  EF-hand_1  EF hand
    0.00074   19.3   1.5      0.011   15.5   0.2    2.3  2  EF-hand_8  EF-hand domain pair
     0.0018   18.6   1.3      0.014   15.8   0.1    2.2  2  EF-hand_7  EF-hand domain pair
  ------ inclusion threshold ------
       0.16   11.0   0.1       0.22   10.6   0.1    1.2  1  Cas_Csy1   CRISPR-associated protein (Cas_Csy1)
        2.2    7.9   5.8        0.4   10.3   0.4    2.2  2  EF-hand_5  EF hand


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   1.3     0.012        42       3      14 ..      39      50 ..      37      52 .. 0.85
   2 !   19.5   0.9   1.3e-07   0.00046       1      20 [.     152     171 ..     152     171 .. 0.96

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.012
                HHHHHHHTTTSS CS
   EF-hand_1  3 keiFrefDkDgd 14
                 ++F ++D D++
  EFC38862.1 39 FDMFVKMDIDKN 50
                68********98 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 1.3e-07
                 HHHHHHHHHTTTSSSEEEHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfe 20 
                 elk++++e+D Dg+G I+f+
  EFC38862.1 152 ELKDMIKEVDADGNGEIEFD 171
                 79****************97 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.1     0.028     1e+02      27      41 ..      37      51 ..      28      52 .. 0.89
   2 !   15.5   0.2   3.2e-06     0.011      13      46 ..     140     171 ..     131     171 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.028
   EF-hand_8 27 evdilfrefDtdgdG 41
                e+ ++f ++D+d+++
  EFC38862.1 37 EAFDMFVKMDIDKNN 51
                6899********985 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 3.2e-06
   EF-hand_8  13 ilrilglkkglseeevdilfrefDtdgdGkisfe 46 
                 i+r+l ++   +e e+ ++++e+D dg+G i f+
  EFC38862.1 140 IMRSLFQN--PTETELKDMIKEVDADGNGEIEFD 171
                 66555445..89*****************99886 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.12   4.2e+02      47      58 ..      36      50 ..      16      56 .. 0.59
   2 !   15.8   0.1   3.9e-06     0.014      28      64 ..     141     171 ..     117     172 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.12
   EF-hand_7 47 ellfkef...Dtdkd 58
                ++ f++f   D dk+
  EFC38862.1 36 REAFDMFvkmDIDKN 50
                334444444466554 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 3.9e-06
   EF-hand_7  28 lrkifqgagegsklsdeelellfkefDtdkdGvisfd 64 
                 +r      +   +++++el++++ke+D d++G+i fd
  EFC38862.1 141 MR------SLFQNPTETELKDMIKEVDADGNGEIEFD 171
                 44......5556779********************97 PP

>> Cas_Csy1  CRISPR-associated protein (Cas_Csy1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.1   6.1e-05      0.22     222     275 ..       2      53 ..       1      60 [. 0.89

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 6.1e-05
    Cas_Csy1 222 aSlPPqlkqrkrlplklesvfprkdlfkeslevrelvdelkrllklvkekennl 275
                 +S+PP+++++  l  + +s fp+ ++  + ++ re++++++ ++k++ +k+nn 
  EFC38862.1   2 SSIPPSISATPALDDSKNSNFPKVNF--SEKQLREYREAFDMFVKMDIDKNNNS 53 
                 79*********9***********774..4558******************8885 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.8      0.24   8.6e+02       3      13 ..      40      50 ..      40      52 .. 0.70
   2 ?   10.3   0.4   0.00011       0.4       1      18 [.     153     170 ..     153     171 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.24
                HHHHHH-SS-S CS
   EF-hand_5  3 dtFqaiDlNgD 13
                d+F ++D ++ 
  EFC38862.1 40 DMFVKMDIDKN 50
                56888888864 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00011
                 HHHHHHHH-SS-SSCE-H CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIsk 18 
                 lkd+ +++D++g G I +
  EFC38862.1 153 LKDMIKEVDADGNGEIEF 170
                 7999************87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       863  (0.0481343); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.30s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1162.19
//
Query:       EFC38863.1  [L=1408]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
          0 1346.8  43.6          0 1036.1  18.5    3.1  3  Strumpellin   Hereditary spastic paraplegia protein strumpell
  ------ inclusion threshold ------
      0.056   13.1   0.0        1.3    8.7   0.0    2.6  2  NOD           NOTCH protein


Domain annotation for each model (and alignments):
>> Strumpellin  Hereditary spastic paraplegia protein strumpellin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ! 1036.1  18.5         0         0       1     710 [.      26     782 ..      26     811 .. 0.97
   2 !  232.9  16.9   6.8e-73   6.1e-69     714     982 ..     851    1162 ..     820    1189 .. 0.87
   3 !   83.0   0.0   1.3e-27   1.2e-23     956    1086 .]    1188    1353 ..    1162    1353 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1036.1 bits;  conditional E-value: 0
  Strumpellin   1 naiiaellrLsdliPeefetkeeeskyaeiifDFsYfkeaeeiekkiesseelleldeelrenylellerfyllfesiykYvtdlnrfleeleegvyi 98 
                  naiiaellrLs++iP +f    e++ky+ iifDF+Y+k++++++++i ss++ll+lde++++++++llerfy lf+siy+Y++d+ +f+++l++g+yi
   EFC38863.1  26 NAIIAELLRLSNYIPPVF--FLEDKKYQYIIFDFKYLKNQDAFDNRITSSADLLDLDENFKDSHMPLLERFYTLFKSIYNYYKDFIKFMNDLDQGYYI 121
                  8*****************..9999************************************************************************** PP

  Strumpellin  99 qqtlesvlededGkqllcEalyLyGvmLllldlkiegkvRerllvsyyRykgsketesnidevckLlrstgyskds........ssves......... 179
                  qqtles+l ++dGkqll+E+lyLyG+mLllldlki+g+vRer+l+sy+Rykg+ e   nid+vckL+rstg+++          +   +         
   EFC38863.1 122 QQTLESILVNQDGKQLLAESLYLYGCMLLLLDLKIPGPVRERMLMSYFRYKGAGE-IPNIDDVCKLCRSTGFDSTYylhlkyfaQ---Qhahhntgnn 215
                  ******************************************************7.*****************977777766641...1446678889 PP

  Strumpellin 180 ...............................................krpsnyPeeyfkRvplnkklvklvigrlrsddiYnqlsayPepehrstala 230
                                                                 + p++yP +yf+R+ l+++lv+++igrlrsddiY q+s yP pehrs+al+
   EFC38863.1 216 gaifydhsnnsssnnthdhhssthhspssnssgggngsggsggitppQYPESYPCDYFNRFALPDQLVSMIIGRLRSDDIYLQTSYYPLPEHRSVALS 313
                  999999999999************************************************************************************** PP

  Strumpellin 231 tQaamlyviLfFapkiLhnqtavmreiVdkfFadnWvvsiymGitvdLseaWekykaAktAlsntlessnvkelaqkqk.eklkkllkkvkevlkegv 327
                  tQaaml++iL+F+p++L++++avmreiVdk+F+dnWv+s+ymG+tvdL+ +W+++kaA+ A++n+++ ++vk+l+++   + l kl+++++++l egv
   EFC38863.1 314 TQAAMLFIILYFKPNMLNSEQAVMREIVDKHFPDNWVLSYYMGFTVDLTMVWKDFKAANLAIQNIVTLNHVKNLTDNFYnQLLPKLIEQLNQYLIEGV 411
                  ***************************************************************************9865155789************* PP

  Strumpellin 328 lteeyvLdniskllnlvrecNvtlrWllLhtaksavasekskkakqlrdlvlaelklskeellelLLetsqlElklkeifkelleekeerwekskkea 425
                  l eeyvLdni++ll+++recNvtlrWllLh++          k++++++l+ + +  ++e++l lLL+t+q+E+ lk++f+e+l++ke +w+++k++a
   EFC38863.1 412 LVEEYVLDNINRLLSCLRECNVTLRWLLLHRT---------SKNRKVYELIDQMT--NSEDILLLLLNTAQFEFLLKQMFQEMLDSKEIKWSECKNQA 498
                  ********************************.........799*******8877..9**************************************** PP

  Strumpellin 426 vermkeLsevFsgekpLsrveknesLqkwfaelakqiesLdyedstaagrkiqqliqALeevqefhqlesnlqvkqflaetrklLkqmirtinikeev 523
                    rm eLs++Fsgek+L+   k+e+Lq+wf+e++++i +Ldy+dst agr+iqq+i+ALe+v++fhq+e++lqvkq+l++tr lLk+mir++ni+e+v
   EFC38863.1 499 HLRMIELSQYFSGEKALTP-IKDEQLQEWFSEMSNRIIELDYHDSTLAGRRIQQVISALEDVEQFHQIEQSLQVKQYLSDTRLLLKKMIRYVNIRESV 595
                  ******************9.589*************************************************************************** PP

  Strumpellin 524 litlqiisDlsYawelldsyvellqekikkdPslvlkLralFlKlaSiLelpllRinqaesedlesvseyYSeeLvsyvrkVLqiiPesvFeiLakii 621
                  l  ++i+sD+sYawe++ +yv+ +q++ikkdPsl++k+r++FlKl+ +Lelpl+Ri+qa+s+d++svs+yYS+eLv++vr  L+iiP s+F+iL+kii
   EFC38863.1 596 LVGIAIVSDISYAWEIVGDYVKSMQRRIKKDPSLIIKMRSTFLKLSTMLELPLVRISQAKSQDIVSVSQYYSSELVKFVRFTLEIIPMSMFSILNKII 693
                  ************************************************************************************************** PP

  Strumpellin 622 klqtnalkelptrlekdklkeyaqleeRyqlakltheisvfteGilamkttlvGvievdpkqlLedGiRkeLvkqiakalhkglvfdkk 710
                  ++qtn+l+elpt+l +++lk+++ql+eRy+l++ t+e+s +teGilam++tl+G++e+dpkqlLedGiRkeLv+qia+alh++l+f+++
   EFC38863.1 694 EVQTNRLEELPTKLPRNELKRFSQLDERYDLSRSTYEVSKYTEGILAMERTLMGIVEIDPKQLLEDGIRKELVRQIAMALHSNLIFNSS 782
                  **************************************************************************************985 PP

  == domain 2  score: 232.9 bits;  conditional E-value: 6.8e-73
  Strumpellin  714 seeleekLeeLaerlegyrrsfeyiqdYvniqglkiwqeElsriinynveqecnaflkkkvqdweseyqsksipipkfepld.........kksvn 800 
                   ++ +e+kL +L+++l+g+ rsfeyiqdYv+++glk+wqeE+srii ynveqecn++lk+kv d +s yqs++ipip+f++++          +  n
   EFC38863.1  851 TRLFEDKLGKLHSQLDGMLRSFEYIQDYVHVYGLKLWQEEFSRIIMYNVEQECNTYLKRKVFDFQSLYQSEVIPIPRFKSIQsqqmidkqsITILN 946 
                   36799**************************************************************************99667788744334569 PP

  Strumpellin  801 flgrlarellritdpkttvYleatsgWy..............................dkktkkevvglktfslleealgvlGlagldrllsfmiv 866 
                   f+grl+ ell  td ++t+Y+e+ sgWy                              ++ +k+e++gl  f+ll+++++ +Gl+gld lls++iv
   EFC38863.1  947 FMGRLMVELLVQTDSRRTIYIEQLSGWYdydsnflnsssnsnsnnsnsnssnsssnnsNI-KKEEIIGLTCFTLLQQTVSSFGLVGLDLLLSYRIV 1041
                   ******************************************************987444.49********************************* PP

  Strumpellin  867 keLqkllkllekelskekellealeelkkelepessipekalkvyakllkkvek..vleellevllkvGqlqllrkqiaaelkssakvdsksleaa 960 
                   + L++++k++ k+l +  +++++l+ +k+ ++p +++pe+  k+y+++l+ + +  +++ +l  +++vG  qllrk+ia++l +++k++++ l+++
   EFC38863.1 1042 TLLNQFVKQYLKHL-NIDSIKKHLKFFKDFITPPNTLPEQLGKIYEQVLNLLPSqiFTHVFLYYVMQVGTCQLLRKHIASQLLFTCKLNANPLFNT 1136
                   *******9999998.677899*****************************998874455899********************************** PP

  Strumpellin  961 letlnealladlkk....hykdpesk 982 
                   l++ln+a+l+d+++    hyk++ ++
   EFC38863.1 1137 LTNLNHAILKDVEHyfdiHYKNQANQ 1162
                   ************86222233333333 PP

  == domain 3  score: 83.0 bits;  conditional E-value: 1.3e-27
  Strumpellin  956 sleaaletlnealladl.kkhykdpeskplpeeseellaelsklleavGlsdplekvYittk.................................. 1016
                   + +++ ++ ++  ++++  k++++ +   +p+e++ +++el+++l+++G+++p+ek+Yit +                                  
   EFC38863.1 1188 NNNQSNQSNQSNNMNNIsIKSTRQLDGVGYPSENNPIFSELTQYLQTSGMHQPFEKIYITPNliiqnsgigistssktsknfnsnininnnnsngn 1283
                   3334444444445666633344455788999**************************************************************996 PP

  Strumpellin 1017 pleelslllflfvlsqlsklqydkkldslvkkkkkdsldgvplvvGlltlLkqfhssetklflsylgqyv 1086
                     +++s+++flfvl++++++ y  ++d+lv+kkk d ldg+p++vG+ t+Lkqfhss+t+lfls++gqy+
   EFC38863.1 1284 IGDYISVTMFLFVLNCIERFIYVPSIDCLVSKKKGDILDGTPFIVGIYTVLKQFHSSQTHLFLSFIGQYI 1353
                   699******************************************************************7 PP

>> NOD  NOTCH protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0   0.00015       1.3       8      45 ..     744     783 ..     740     788 .. 0.84
   2 ?    1.1   0.0     0.034     3e+02      18      39 ..    1335    1357 ..    1327    1368 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00015
         NOD   8 sLvlvVlidpeellnnske..FLrelsalLrtnvrikkde 45 
                 +L+ +V idp++ll+++ +    r++  +L++n+ +   +
  EFC38863.1 744 TLMGIVEIDPKQLLEDGIRkeLVRQIAMALHSNLIFNSSQ 783
                 56779**********986555*************997655 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.034
         NOD   18 eellnnske.FLrelsalLrtnv 39  
                  +++ ++++  FL  +++ +r+n 
  EFC38863.1 1335 KQFHSSQTHlFLSFIGQYIRANT 1357
                  7888888889***********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1408 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1553  (0.0866194); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.01u 0.39s 00:00:01.40 Elapsed: 00:00:00.56
# Mc/sec: 7593.45
//
Query:       EFC38864.1  [L=503]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.042   13.3   0.0        9.8    5.5   0.0    2.2  2  GPI2      Phosphatidylinositol N-acetylglucosaminyltransferas


Domain annotation for each model (and alignments):
>> GPI2  Phosphatidylinositol N-acetylglucosaminyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0   0.00055       9.8     135     179 ..      95     151 ..      93     158 .. 0.75
   2 ?    5.2   0.0   0.00067        12     135     178 ..     241     296 ..     239     307 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.00055
        GPI2 135 DSIwalsfwlllinifffdysiekkkskekeek............lvaslStnaalm 179
                 D+Iw   f+ +l n++ f+y+++++ ++ + +             + ++ S+n+ ++
  EFC38864.1  95 DTIWEYYFVTCLHNTLPFEYEYNNEVVQLSLRMmkgilgknhrfePLSTRSMNCTIL 151
                 9********************998887654443667777777665555566666555 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.00067
        GPI2 135 DSIwalsfwlllinifffdysiekkkskekeek............lvaslStnaal 178
                 D+Iw   f+ +l n++ f+y+++++ ++ + +             + +  S+n+ +
  EFC38864.1 241 DTIWEYYFVTCLHNTLPFEYEYNNEVVQLSLRMikgilgknhrfePLSARSMNCTI 296
                 9********************99887765443366666665555544555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       386  (0.0215294); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2903.57
//
Query:       EFC38865.1  [L=612]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-10   39.6   0.0    5.8e-10   38.9   0.0    1.3  1  START     START domain
    9.3e-10   38.8   5.8    9.3e-10   38.8   5.8    1.9  2  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.9   0.0   6.5e-14   5.8e-10      42     187 ..     372     530 ..     332     555 .. 0.79

  Alignments for each domain:
  == domain 1  score: 38.9 bits;  conditional E-value: 6.5e-14
                 -......SCEEEEEEEECCSCHHHHHHHHHCCCGGG.TTCT-TT-SEEEEEEEECTT.......EEEEEEEE--TT..-SS-EEEEEEEEEEE...... CS
       START  42 v......ksgealraigvvdmvaallveellkdaey.raqWdktlasaetvevissg.......galqlyvaelvalsplspRdfvflRsire.....l 121
                         +++ ++  g++ +++++++  l++++ y ++   ++++s + +e i+++        ++   v ++ +  pls+R+f   +s r+     +
  EFC38865.1 372 LkldkkkRTIQLFKETGILNATPEEVLTALIDSRYYsMV--ENQIISTDFLEFIEDDeeedglgVSYSRSVVKMPW--PLSNREFILGSSVRReigidS 466
                 14444456999*************888888888866333..688889***************999999********..*******************88 PP

                 TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEEXEEXXSSXXHHHHHHH CS
       START 122 gdgsyvivdrSvtseqnppesssvvRaellpSgilieplgnghskvtwvehvdlkgwlpkwllrsl 187
                 ++ +++i+ r +++ + p  ++++vR ++++ gilie+l++ h++ t +  +dl+g +p +l + l
  EFC38865.1 467 TESDFLILRRGIENSKVPI-TKGCVR-GRYIGGILIEKLSDIHTRYTAMAFIDLGGIVPLSLWNKL 530
                 8888888887777776666.9*****.89******************************5555444 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.8   5.8     1e-13   9.3e-10      16     117 ..     116     221 ..     104     222 .. 0.91
   2 ?   -2.6   0.0      0.73   6.6e+03       4      25 ..     408     429 ..     405     432 .. 0.78

  Alignments for each domain:
  == domain 1  score: 38.8 bits;  conditional E-value: 1e-13
                 HHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS....STTTTTTHHHHHHHHHHHHHHHHHHHH CS
         RGS  16 reFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke....qpsrklfeeaqeevfellekdsypkFl 110
                  eFl++e +   l+F++ + ef+k+k+   + ++ + I+++++ ++s++++n+++++re + +++ +       +++lf++a+  v   l++d + +F 
  EFC38865.1 116 NEFLKRELNLSSLEFLIRIAEFNKMKDPLTRFQQSQMIIDAFFREESDSQINLNNNIREIVIAKFYNYaseeFVDPNLFDNAKVDVSIQLKSDNFLRFT 214
                 69********************************************************987766655556658899*********************** PP

                 TSHHHHH CS
         RGS 111 kselylr 117
                 +s+ +++
  EFC38865.1 215 QSKQFTD 221
                 ***9975 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.73
                 HHHTSHHHHHHHHHHHHHTTCT CS
         RGS   4 slledqpgrslFreFlesefse 25 
                 s++e+q     F eF+e+ ++e
  EFC38865.1 408 SMVENQIISTDFLEFIEDDEEE 429
                 6788899999999999997776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (612 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1117  (0.0623013); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 3718.10
//
Query:       EFC38866.1  [L=399]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       733  (0.0408835); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.35s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 2249.38
//
Query:       EFC38867.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 991.14
//
Query:       EFC38868.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.5e-34  119.0   0.0    3.5e-34  117.8   0.0    1.6  2  DUF1298         Protein of unknown function (DUF1298)
  ------ inclusion threshold ------
      0.012   15.4   0.0       0.28   10.9   0.0    2.5  2  WES_acyltransf  Wax ester synthase-like Acyl-CoA acyltransfer
      0.015   14.0   0.0      0.062   12.0   0.1    1.8  2  Condensation    Condensation domain
        0.2   11.2   3.4       0.54    9.8   3.4    1.8  1  FGFR3_TM        Fibroblast growth factor receptor 3 transmemb


Domain annotation for each model (and alignments):
>> DUF1298  Protein of unknown function (DUF1298)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       1.4   6.2e+03      66      96 ..     190     220 ..     171     223 .. 0.72
   2 !  117.8   0.0   7.8e-38   3.5e-34       2     144 ..     360     509 ..     359     510 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.4
     DUF1298  66 lsnttlviSNvpGPqeelylaGaplkaiypv 96 
                  +++ ++i N+ G   ++ l+G+ +++++++
  EFC38868.1 190 WNSALTIINNLTGKLNRIPLLGSLVSYCIGF 220
                 5566678889999999999999988888765 PP

  == domain 2  score: 117.8 bits;  conditional E-value: 7.8e-38
     DUF1298   2 GNqigvvllpLpidl...adPlerlrkakkamdrkKrsleavltylllelllkllpakvaaalikrllsnttlviSNvpG....PqeelylaGaplkai 93 
                 GN +gv++ ++p+++   ++P++r+++++++m+ +K  ++++++++ll+l ++llp+k+a +l+++ + +tt+++SNv+G    ++ +++++G+++++ 
  EFC38868.1 360 GNIVGVIFGSIPLNIqliEEPQKRFETVRNNMNFAKFLPQPYFNRYLLWLGTALLPKKMAVSLMNWGAASTTFTCSNVQGfeadDKLKYTMLGRNIVQG 458
                 9******988887664478****************************************************************99************** PP

     DUF1298  94 ypvvpglpgqalnitvlSyagklriglavdkdlvpdpqkllddleealeel 144
                 ++++p+++++a+n+t++++++++ +++++dk++++d+++++++++e++ +l
  EFC38868.1 459 AGFIPLVSAVAVNCTLMTFNDRVGLSIVCDKGIIQDIHMYAECFREEFIAL 509
                 ************************************************887 PP

>> WES_acyltransf  Wax ester synthase-like Acyl-CoA acyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.44     2e+03       8      62 ..       5      56 ..       2      89 .. 0.61
   2 ?   10.9   0.0   6.2e-05      0.28     114     262 ..     126     305 ..     123     307 .. 0.58

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.44
  WES_acyltransf  8 flelesaetpmhvgalavleppskgagelllrrlreaieqreeraprlrqkvvee 62
                    +   es +tp  vg l +l+++++ ++   +++   +i  r++ ++rl+++++++
      EFC38868.1  5 MVMQESETTPCVVGGLVLLSAKDDNNNN--IEEKIHRID-RKAFEERLKERLLQR 56
                    6677999999999999999988666555..444433332.222233333333333 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 6.2e-05
  WES_acyltransf 114 PlWevhviEGleggriAillkvHHAliDGvgglkll.arlldldpddpp.rpeppqvpprdrsrtqlrasg........................ 182
                     PlWe+ viE   +g i + +++HH + DG   +k++   lld+++++++ ++ +++ + ++++++  +a                          
      EFC38868.1 126 PLWECIVIENYSRGLI-LFFRIHHWIGDGTLLQKIVgTDLLDNEKEASEyVQSKFDKIMKGSHSNWNSA-Ltiinnltgklnripllgslvsyci 218
                     9********9999977.89**********9888875256777777665413444444554432222222.1345566666666666666666666 PP

  WES_acyltransf 183 .....alvglvaglgkvlgsvagvvssagrlleaalearslvlpfaap..rtplntplsraRrfaaaslpLadvkavakalgvtiND 262
                          +l+ ++     +  +v+g  ++++r++++  ++ +++ +f        l    ++ R+ +   +   + k+vak+l++++ND
      EFC38868.1 219 gfflkILAFVATFFLILGIGVKGEPDTMFRASKKHPKCGQVTCSFIWFndTEQLRDDENDLRNETDKYFTVPEFKKVAKKLDGKLND 305
                     655533333333333333456666666666666655666666555443212333355556666666666666666666666666666 PP

>> Condensation  Condensation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   1.4e-05     0.062      39     146 ..      40     155 ..      35     174 .. 0.74
   2 ?   -0.9   0.0      0.11     5e+02     239     298 ..     291     350 ..     272     383 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.4e-05
                   --HHHHHHHHHH.HHHH-SSCCEEEEE..TTEEEEEE-...TT-----EEEE-T..TSSSHHHHHHHHHHHHHTC--S......CCCS..-SEEEEE CS
  Condensation  39 ldlerlekalqe.lierhdaLRtvfleeengepvQvil...eerevelevleisdleeseeeeaieefaqkdlqepfd......Lekg..pLfraal 123
                   +d +++e+ l+e l++r+  +R +++ e  + +   ++    e +v+ e+l++s  +e++e+e+++e++   l +pf+      + kg  pL+   +
    EFC38868.1  40 IDRKAFEERLKErLLQRYVRFRSILVSE-SEYIDIGVDevcLENHVKYEMLNLS--KEKSEDEILSELIGSRLFSPFKpvensqV-KGviPLWECIV 132
                   6667777777654677777777777655.222222222244678999999****..78888999*******9*****75332222.33579****** PP

                   EESSTTEEEEEEEEECCT--TTT CS
  Condensation 124 fkiaenrlllllsvHHiivDGvS 146
                   ++  +++l l++++HH i DG  
    EFC38868.1 133 IENYSRGLILFFRIHHWIGDGTL 155
                   *********************75 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.11
                   HHHHHHHSTSS-HHHHHHHHHHHHHHHHHT-SEEEEEEEEESSTTCSTCHHC--SS-EEE CS
  Condensation 239 klrklakeqgvtlndvllaalgllLskytgqddivvgteisgReseikdiermvGlFvnt 298
                   +++k+ak+ + +lnd++l++l+ +  +y  +  +  ++ +  Re+  ++ +  +G+ vn+
    EFC38868.1 291 EFKKVAKKLDGKLNDLFLSLLSGASDRYRLKLSAKESSNMQEREKLLSTTNARMGMGVNI 350
                   678899999999999999999999999999999999999999999777888888888887 PP

>> FGFR3_TM  Fibroblast growth factor receptor 3 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   3.4   0.00012      0.54       9      23 ..     214     228 ..     212     237 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00012
    FGFR3_TM   9 LIYctGffLiilmVv 23 
                 ++Yc+GffL il+ v
  EFC38868.1 214 VSYCIGFFLKILAFV 228
                 89*******999877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       766  (0.0427241); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.47
# Mc/sec: 3266.09
//
Query:       EFC38869.1  [L=640]
Description: Hypothetical protein NAEGRDRAFT_59396 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        3.4    8.2  10.9         58    4.3   0.1    5.0  5  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.21   3.8e+03      22      30 ..     175     183 ..     169     190 .. 0.74
   2 ?    4.3   0.1    0.0032        58       2      30 ..     354     379 ..     353     386 .. 0.85
   3 ?    1.8   1.1      0.02   3.6e+02       1      25 [.     418     448 ..     418     452 .. 0.80
   4 ?    3.9   0.1    0.0043        77      15      30 ..     459     474 ..     458     481 .. 0.87
   5 ?   -0.9   0.0      0.15   2.6e+03      22      32 ..     490     500 ..     482     512 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.21
                 -TT--EEE- CS
       LRR_4  22 lpnLkeLdL 30 
                 +++Lk+L L
  EFC38869.1 175 FKKLKVLRL 183
                 778888877 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.0032
                 S--EEE--SS---E-S-HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdL 30 
                 +L+ L Lsn ++ + +    l+nL+++ L
  EFC38869.1 354 HLRRLELSNAKIVTNQC---LKNLEVVIL 379
                 699*****999999888...999999855 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.02
                 SS--EEE--SS-.......--E-S-HHH-TT- CS
       LRR_4   1 pnLevLdLsnNq.......ltdiplleklpnL 25 
                 ++L++L L n++       l++++ l+ l+ L
  EFC38869.1 418 TRLTELILKNTRhlvqqfyLSTLQDLN-LTAL 448
                 689******998888888877777777.7776 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.0043
                 E-S-HHH-TT--EEE- CS
       LRR_4  15 diplleklpnLkeLdL 30 
                 +++ le++ +L++L++
  EFC38869.1 459 ELQYLENMSSLEYLNI 474
                 5788999********9 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 0.15
                 -TT--EEE-.- CS
       LRR_4  22 lpnLkeLdLsg 32 
                 + nLk++++s 
  EFC38869.1 490 MINLKVFNVSY 500
                 899**999965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (640 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 3751.07
//
Query:       EFC38870.1  [L=770]
Description: Hypothetical protein NAEGRDRAFT_81464 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.012   15.7   0.2        0.1   12.7   0.2    2.6  1  Polbeta   Polymerase beta, Nucleotidyltransferase


Domain annotation for each model (and alignments):
>> Polbeta  Polymerase beta, Nucleotidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.2   5.7e-06       0.1      11      72 ..      57     168 ..      51     177 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.7e-06
                 HHHHSTTEEEEEE-S---....................................---EEEEEEEESS-...............--HHHHHHHHHHHHHH CS
     Polbeta  11 keielaylFGSrakgkar....................................eeSDiDlavllkek...............ldleeelelaaeledi 58 
                 ++++ +y+FGS+a   +                                      eSD+D+ ++++e                 ++e+++++++ l + 
  EFC38870.1  57 DQVRGMYIFGSQAYYSQVrdagsiepygvtdshgneligvcwrndekkeviqylAESDFDIILVVDEYkstdellgalasdmqSKWETQISIKTCLGED 155
                 378999******96666569999***********************999999999*************8777777777777766677777777777777 PP

                 .SSSEEEEEETTTS CS
     Polbeta  59 klgkkvDlvdlnea 72 
                  ++ k+D+ ++n++
  EFC38870.1 156 -IEFKLDVSVYNTS 168
                 .7788888888754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (770 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       731  (0.0407719); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 4553.91
//
Query:       EFC38871.1  [L=431]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.7e-10   38.4   8.5    2.4e-09   37.0   8.5    1.8  1  Pkinase   Protein kinase domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   8.5   1.3e-13   2.4e-09      57     260 ..     163     415 ..      99     419 .. 0.70

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 1.3e-13
                 CTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE...EEE-SGTTSEESS CS
     Pkinase  57 hpnivrlyevfee..kdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDFGlakele 149
                   +++r  ++f++  ++  ++++e +e + + ++le++++ + ++  + ++ i+  ++ lHs +i+H+D K++N+L +   +e   l  +DF  +  ++
  EFC38871.1 163 LVKVLRAGHAFSDdgSEMKFVLMERCEAD-FSKYLEKNKISNITDFLNKVELICLCVKDLHSLNIVHMDTKSDNLLSKfV-NEiftLLFCDFEESIDVS 259
                 33344444444446444455889****77.******99999999********************************9953.33478999*********9 PP

                 SSCS............BCTTTSCGGGS-HHHH..........TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH. CS
     Pkinase 150 sssk............ltsfvgtseYlAPEvl..........keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg.etke 225
                   +                   t    +PE             ++++   +D Ws+G+ ++ l+ +  + +  +g+e+  ++ ++       ++ +t++
  EFC38871.1 260 DMEIfndkviislpttG-----TDFVNSPESYyckynfgnriIHTNFMFRMDSWSVGINILLLILKFLLNY--NGSEELVMKRMK------CFHeNTNQ 345
                 98888899998666662.....44444444443333333222579999***********999988887777..333322222222......11112222 PP

                 ..HHHTTS......................................-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 226 klpeasei......................................seeakdllkkllkkdpkkRltaeellq 260
                 ++++   +                                         +++ l  ll+kdp+kR+++++ll+
  EFC38871.1 346 EYEK---LigfgewvaahdsheaihsfinevidelvhkypelsdrqTTMLQETLCGLLHKDPSKRMSIDKLLE 415
                 2222...12335556666777777999999************9998888899999**************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (431 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       854  (0.0476323); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.56
# Mc/sec: 2323.63
//
Query:       EFC38872.1  [L=726]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-05   25.5   0.2      7e-05   22.9   0.2    2.3  1  MMR_HSR1  50S ribosome-binding GTPase
     0.0066   15.9   0.1       0.04   13.3   0.0    2.2  2  SRPRB     Signal recognition particle receptor beta subunit
  ------ inclusion threshold ------
      0.033   13.7   0.0      0.066   12.7   0.0    1.5  1  FeoB_N    Ferrous iron transport protein B
        7.9    6.4  10.5      0.079   12.9   1.2    2.4  3  Med25     Mediator complex subunit 25 PTOV activation and syn


Domain annotation for each model (and alignments):
>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.2   1.6e-08     7e-05       2      78 ..     285     359 ..     284     480 .. 0.68

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 1.6e-08
                 EEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSE CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflaleeadl 78 
                 v ++G  N+GK+ L+n l+g+  +v+ ++ t     +   + +g+++ lvDt Gl  ga +  +++++++++++ + 
  EFC38872.1 285 VSVLGFKNSGKTHLLNELSGSDLRVGLTQSTPALCFKVPKNNQGRDWLLVDTMGL-RGAVRVADVKRQLREIQK-EG 359
                 789******************888877766665555555555679*********5.444444455555554443.22 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0     9e-06      0.04       6      58 ..     285     338 ..     279     356 .. 0.88
   2 ?   -0.9   0.0      0.21   9.2e+02     131     159 ..     611     639 ..     577     650 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 9e-06
                 EEEE-STTSSHHHHHHHHHHSS---B---SS-EEETTG....GGTT-SEEEETT CS
       SRPRB   6 vllvGlsdsGKTslftrLttdsvkktvtSqessaalkv.ksekgskltliDfPG 58 
                 v ++G ++sGKT l++ L+    +   t   + +  kv k+++g  + l+D  G
  EFC38872.1 285 VSVLGFKNSGKTHLLNELSGSDLRVGLTQSTPALCFKVpKNNQGRDWLLVDTMG 338
                 5578***************999999999889999999989***********866 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.21
                 HHHHHHHHHHHHHHHHCHHHHHH------ CS
       SRPRB 131 klikdaLEkElnkiierrskalkeldeee 159
                  l  ++L + +++i ++ + +l+ + +++
  EFC38872.1 611 VLDENSLNNSITQILNSTQPSLSITSSHQ 639
                 33356677777777777777776665444 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.5e-05     0.066       3      28 ..     285     310 ..     283     335 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.5e-05
                 EEEEESTTSSHHHHHHHHHTTSEEEE CS
      FeoB_N   3 valvGnpnvGkttlfnaltgakqkvg 28 
                 v ++G  n+Gkt l+n+l+g++ +vg
  EFC38872.1 285 VSVLGFKNSGKTHLLNELSGSDLRVG 310
                 7899*******************998 PP

>> Med25  Mediator complex subunit 25 PTOV activation and synapsin 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.2       1.2   5.2e+03      19      44 ..     158     181 ..     149     185 .. 0.60
   2 ?   12.9   1.2   1.8e-05     0.079      31     102 ..     389     462 ..     366     485 .. 0.74
   3 ?   -2.7   0.1       1.2   5.3e+03      62      81 ..     587     610 ..     578     633 .. 0.60

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.2
       Med25  19 deeskqkrslpcqvsasvkegepelk 44 
                 ++++++ +s++ q++++++  ++ ++
  EFC38872.1 158 EQNEHIYHSIQNQMTQNSN--HSYIN 181
                 5666777788888843333..33344 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 1.8e-05
       Med25  31 qvsasvkegepel.kaekwPekLimqlipkqlln.alkeallknsrvvvfnftakdlealksLakvmsngfagc 102
                 + +++ +  +pe+ + ++w e ++ ++ +k +l+ +++e ll+ s+ +++ +++ + e++++L+ +++    g+
  EFC38872.1 389 TSTQQQMWIDPEIiQQQQWNEAIKRNVREKRMLEdTIEEVLLNMSHFILYVVNEMTWEEHEKLYDLLNRRDTGI 462
                 33344444566665999****************83577899999*********************998776665 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.2
       Med25  62 lnalkeallknsrvvvfnf....t 81 
                 ++a  ++++ n + v++nf    +
  EFC38872.1 587 IQAALQNHITNIKDVQMNFkikkS 610
                 444445777777888877743321 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (726 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1030  (0.0574488); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.50
# Mc/sec: 4381.79
//
Query:       EFC38873.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-12   47.2   0.0    5.5e-12   46.3   0.0    1.4  1  DUF2263   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF2263  Uncharacterized protein conserved in bacteria (DUF2263)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.3   0.0   3.1e-16   5.5e-12       3     146 .]      32     200 ..      31     200 .. 0.81

  Alignments for each domain:
  == domain 1  score: 46.3 bits;  conditional E-value: 3.1e-16
                 HHHHHHHHTEEE-TTS-EEE-HHHHHHHHHT-EEE-H.........................HHHHHHEEES--HHHHHHHHHHH-SS--EEEEE--SS CS
     DUF2263   3 etleilekgeylnskgekvdlreaveaavkgtklysp...............kkaastseeeeeetkievteestleaarrlvkeegekvavLNfASak 86 
                 e+ ei+++++y+  k+++++l+++++  ++gt+l                   +++s +++ee++t ++v + ++l+ a +l +++g++++vLN+AS++
  EFC38873.1  32 ENKEIFAEQTYYL-KKKEINLSDHIRTIKEGTVLLGHddehkaeeevaqfieLQSSSLPSDEEKKTCFKVLDADCLQVAFELFEKTGRTPMVLNLASRR 129
                 5678999999**9.6666*****************777788889999999875577788899999999******************************* PP

                 STTTTGGGT.--SHHHHHHHHBSHHHHHTT..-HHHHHHHHHH-........-TT--S-EEEEEEEEEEE- CS
     DUF2263  87 npGGGflnG.akAQEEsLarsSaLyasllk..aeefYeahrakr........splysdamiYSpeVpvfrd 146
                    G +       QEE + r+S +y+  ++   +e+  ++ +kr        +++ +  + Y+p+ p++r+
  EFC38873.1 130 TICGKYWVPyLGTQEEFIERKSVIYRYSIDpdLNEIVGKELEKRalntdedpHHILEFGVTYTPQLPIIRN 200
                 **99987652689************9988867677777663333333444445666666889999888885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1944.09
//
Query:       EFC38874.1  [L=496]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.1e-12   45.9   1.5    6.1e-12   45.9   1.5    2.0  2  RGS         Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.017   14.8   0.1      0.036   13.8   0.1    1.6  1  RGS-like    Regulator of G protein signalling-like domain
       0.19   11.8   1.2       0.84    9.7   1.2    2.1  1  Adipogenin  Adipogenin


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.8      0.73   4.3e+03      96      96 ..     129     129 ..     101     172 .. 0.53
   2 !   45.9   1.5     1e-15   6.1e-12       3     103 ..     346     453 ..     344     463 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.73
                 H CS
         RGS  96 e 96 
                 +
  EFC38874.1 129 N 129
                 1 PP

  == domain 2  score: 45.9 bits;  conditional E-value: 1e-15
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.......STTTTTTHHHH CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke.......qpsrklfeeaq 94 
                 e +++++   ++F ++l+++f+ enl  + ++e++k+++  +++kk a++++++yl ++sp +ln++++l +  +  + +          + +lf ++q
  EFC38874.1 346 EMIISNKETFQIFLDYLRKSFCPENLLCYADIEKYKRETALRQRKKIAHRMVKKYLYEDSPFQLNLPSDLYSVKTVIMDNIsfadnqnALTDDLFADIQ 444
                 679999********************************9*******************************977666666669999998999******** PP

                 HHHHHHHHH CS
         RGS  95 eevfellek 103
                  +v++ l +
  EFC38874.1 445 LHVLSNLVD 453
                 ***999864 PP

>> RGS-like  Regulator of G protein signalling-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1     6e-06     0.036      18      77 ..     355     415 ..     339     476 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 6e-06
                 HHHHHHHHHHHS--HHHHHHHHHHHHTT.S-TTHHHHHHHHHHHHHTSTT-TT-----HHH CS
    RGS-like  18 LavflnyvlsqfdPsallfylitdlykq.gtsKetrrvaleifstFleknallrvpvpesl 77 
                   +fl y+   f P  ll+y   + yk  +  ++ +++a  + + +l + ++++ + p +l
  EFC38874.1 355 FQIFLDYLRKSFCPENLLCYADIEKYKReTALRQRKKIAHRMVKKYLYEDSPFQLNLPSDL 415
                 679***********************98566789999**************9999998876 PP

>> Adipogenin  Adipogenin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   1.2   0.00014      0.84      11      34 ..     184     207 ..     178     220 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00014
  Adipogenin  11 dltlsflvfwlclpvalllflliv 34 
                 + t s++vfwl + v l+l+++++
  EFC38874.1 184 NNTASLIVFWLSIGVQLFLWFVLM 207
                 5689************99854333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1936  (0.107981); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 2923.05
//
Query:       EFC38875.1  [L=472]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    8.8e-52  172.6  30.8      3e-10   39.7   0.1    8.5  8  DUF4116    Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.18   11.8   3.0        6.6    6.7   0.1    2.4  2  S_layer_C  S-layer like family, C-terminal region


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6   0.1     3e-13   2.7e-09       2      49 .]      66     113 ..      65     113 .. 0.98
   2 !   31.2   1.7   1.5e-11   1.3e-07       2      47 ..     149     194 ..     148     196 .. 0.95
   3 !   26.5   0.7   4.3e-10   3.9e-06       2      49 .]     222     271 ..     221     271 .. 0.94
   4 !   39.7   0.1   3.3e-14     3e-10       1      45 [.     274     318 ..     274     319 .. 0.98
   5 !   36.8   0.0   2.6e-13   2.3e-09       1      49 []     299     346 ..     299     346 .. 0.98
   6 !    4.2   0.1    0.0039        35      14      35 ..     367     390 ..     364     405 .. 0.77
   7 !   33.0   0.3     4e-12   3.6e-08       1      48 [.     406     453 ..     406     454 .. 0.97
   8 !   19.9   0.5   4.9e-08   0.00044       1      39 [.     431     469 ..     431     470 .. 0.93

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 3e-13
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 rE+++ +++ +g+  ++l ++++nD+e++l Avk++ +a+ ++ e+L+
  EFC38875.1  66 REFIKILLEYCGLFMEHLRDDIQNDRELALIAVKSHADAYWFIGEHLK 113
                 9*********************************************97 PP

  == domain 2  score: 31.2 bits;  conditional E-value: 1.5e-11
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 +++ l++v+kn ++l+y +++L  +k++++kAv +n +a+++a e 
  EFC38875.1 149 EDVLLNLVEKNKYILNYTDKSLLGNKQFMMKAVYRNEYAIEFANEL 194
                 799***************************************9875 PP

  == domain 3  score: 26.5 bits;  conditional E-value: 4.3e-10
     DUF4116   2 rEivleavkkn..gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +E+v +++++   + +l+y++ ++++++ ivl+ vk+n+  +++as+++r
  EFC38875.1 222 EEFVIKYIERSrkPVILEYVDISIRKNRTIVLESVKKNSAEFRFASKMIR 271
                 7********776688********************************987 PP

  == domain 4  score: 39.7 bits;  conditional E-value: 3.3e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 DrEivl a++k+g  l+y+ e Lk Dkeiv +A+ +n+ +l+ya+
  EFC38875.1 274 DREIVLCALRKDGDLLRYVEEPLKYDKEIVEEAIGKNPLSLRYAD 318
                 9******************************************96 PP

  == domain 5  score: 36.8 bits;  conditional E-value: 2.6e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eiv ea+ kn+++l+y++ +++ D eiv  A+ +n +a+ +as+ L+
  EFC38875.1 299 DKEIVEEAIGKNPLSLRYAD-RFRDDTEIVQLAISKNRHAIVHASKRLQ 346
                 9*******************.************************9986 PP

  == domain 6  score: 4.2 bits;  conditional E-value: 0.0039
     DUF4116  14 salkylseeL..knDkeivlkAvk 35 
                 + l+y +++L  ++Dk+ +++A++
  EFC38875.1 367 NMLQYWNDKLslSKDKNDAKEAIR 390
                 56899998854499*********9 PP

  == domain 7  score: 33.0 bits;  conditional E-value: 4e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrE++lea+kk+ ++l  + +++  ++ +v +++++n t+l y+ +++
  EFC38875.1 406 DRELMLEAIKKDAMVLLRVGNSMDLNRSFVRECIQNNYTCLLYIRDHF 453
                 9*******************************************8876 PP

  == domain 8  score: 19.9 bits;  conditional E-value: 4.9e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 +r +v e++++n  +l y+ + +  Dke++l A+ +++t
  EFC38875.1 431 NRSFVRECIQNNYTCLLYIRDHFLLDKEFILDACLNYST 469
                 799******************************988765 PP

>> S_layer_C  S-layer like family, C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.1   0.00074       6.6      29      74 ..     150     195 ..     144     285 .. 0.84
   2 ?    5.4   0.4    0.0018        16      38     151 ..     309     418 ..     289     425 .. 0.76

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00074
   S_layer_C  29 dweakvvidsgitleykdeekledkvvglalkykgdkladikdkdk 74 
                 d  +++v+++   l+y+d++ l +k+ +++ +y++++ ++  ++  
  EFC38875.1 150 DVLLNLVEKNKYILNYTDKSLLGNKQFMMKAVYRNEYAIEFANELI 195
                 66678899999**************************998876655 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0018
   S_layer_C  38 sg.itleykdeekledkvvglalkykgdkladikdkdkvdianyaklkfdDklsvyfkideekevelivgekvkvlsadvkaekikakaeqvvkltaPi 135
                 ++   l+y d ++   ++v+la+ ++   ++  ++  +++ +  +    dD  s + +   e+++ ++ ++k++  ++   a++      ++++++ P 
  EFC38875.1 309 KNpLSLRYADRFRDDTEIVQLAISKNRHAIVHASKRLQDEFQSQV----DD-QSTEEEWSIERNMLQYWNDKLSLSKDKNDAKEAIRLGFVPSNINYPE 402
                 335899999998888899999999999999998888888877666....55.2334444446777788888888777766677777788999******* PP

   S_layer_C 136 vvLDtEveldsvdknL 151
                 +  D E  l+  +k+ 
  EFC38875.1 403 IYKDRELMLEAIKKDA 418
                 **********999984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (472 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.37s 00:00:01.01 Elapsed: 00:00:00.57
# Mc/sec: 2511.60
//
Query:       EFC38876.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.5e-24   83.0   0.1    1.7e-23   82.1   0.1    1.5  1  ubiquitin    Ubiquitin family
    4.6e-10   39.2   0.1    7.7e-10   38.5   0.1    1.4  1  Rad60-SLD    Ubiquitin-2 like Rad60 SUMO-like
  ------ inclusion threshold ------
        0.1   12.7   0.0        0.2   11.7   0.0    1.5  1  Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
       0.12   12.3   0.0       0.25   11.3   0.0    1.5  1  TBK1_ULD     TANK binding kinase 1 ubiquitin-like domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.1   0.1   3.9e-27   1.7e-23       1      72 []     217     288 ..     217     288 .. 0.98

  Alignments for each domain:
  == domain 1  score: 82.1 bits;  conditional E-value: 3.9e-27
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 ++vktl+gk+i +  +++d++e++K ++++  g p++qqrLi++Gk+Led rtl++y+i++g +lhlvlrlr
  EFC38876.1 217 VLVKTLTGKTIVVYTDSNDQIEDVKYAVQMADGTPPDQQRLIFAGKQLEDGRTLKDYNITNGGVLHLVLRLR 288
                 68*******************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.5   0.1   1.7e-13   7.7e-10       1      72 []     215     285 ..     215     285 .. 0.98

  Alignments for each domain:
  == domain 1  score: 38.5 bits;  conditional E-value: 1.7e-13
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 +k+ +k+ +gk++ +  +++ ++++++ a + + g+p+ +++rLiF G++L++  t++d+ i++g ++++v+
  EFC38876.1 215 MKVLVKTLTGKTIVVYTDSNDQIEDVKYAVQMADGTPP-DQQRLIFAGKQLEDGRTLKDYNITNGGVLHLVL 285
                 799***********************************.*****************************9986 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   4.5e-05       0.2      50      87 ..     254     285 ..     239     299 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.5e-05
                  CEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  50 dlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                  + +li aGk Le+ +tlk+++++ g v      +H+v+
   EFC38876.1 254 QQRLIFAGKQLEDGRTLKDYNITNGGV------LHLVL 285
                  669*****************9988877......56665 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   5.6e-05      0.25      14      53 ..     226     265 ..     220     278 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5.6e-05
    TBK1_ULD  14 lhkiYihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 ++ +Y +++++++ +  +v+    +++++Q l+f g++l 
  EFC38876.1 226 TIVVYTDSNDQIEDVKYAVQMADGTPPDQQRLIFAGKQLE 265
                 5789*********************************874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       446  (0.0248759); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 2257.64
//
Query:       EFC38877.1  [L=583]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.5e-07   30.1   4.1    1.5e-06   28.4   4.1    1.9  1  RGS            Regulator of G protein signaling domain
  ------ inclusion threshold ------
        1.1    8.8   6.3       0.32   10.5   0.5    2.6  2  Phospholamban  Phospholamban


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   4.1   1.7e-10   1.5e-06       5     116 ..     374     546 ..     371     548 .. 0.91

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 1.7e-10
                 HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS........................................................SHHHHHH CS
         RGS   5 lledqpgrslFreFlesefseenlsFwlaveefkka........................................................keqeelk 47 
                  + d+++r+lFr+ +++e s +n  +++++ ++k                                                          + +++  
  EFC38877.1 374 TMRDNKLRKLFRDHCKQELSLDNYLLLDKITDYKILceksfeiqvflyddmspnshsdslsdsgssatanssnldhqhkkkkkkgytekdlhEIEKKKY 472
                 578999****************************999***************************************************98854455555 PP

                 HHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS  48 kkakeIyneylapsspkelnidkklreelekrleke......qpsrklfeeaqeevfellekdsypkFlkselyl 116
                 + a+eIy  +l+ + +k++ni+k+  ++++++l         + + +lf+++++e++ l+  d +++F ++  ++
  EFC38877.1 473 EIAFEIYTDFLDINGDKSVNINKSAADRVKEQLDYFasgeneHLTDTLFDNVESEICVLML-DTHHRFKQTVEFQ 546
                 55******************************98777888889**************9995.7788999888776 PP

>> Phospholamban  Phospholamban
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.5   3.5e-05      0.32      15      46 ..     144     175 ..     135     180 .. 0.82
   2 ?   -0.1   0.8     0.075   6.7e+02      33      48 ..     327     341 ..     318     344 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 3.5e-05
  Phospholamban  15 AstievnqqakrnLqdLiinFsLiLiCLLLiy 46 
                     stie+ +    nL  Li+nF   +  L+Li+
     EFC38877.1 144 GSTIELTPVKFLNLSSLIVNFLAFMALLILIV 175
                    49*******************87776666664 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.075
  Phospholamban  33 inFsLiLiCLLLiyii 48 
                       sLi++C+  i+i+
     EFC38877.1 327 TTISLIVVCV-SICIV 341
                    4578999996.46665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (583 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1771  (0.0987785); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 3359.48
//
Query:       EFC38878.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       347  (0.0193541); expected 358.6 (0.02)
Passed bias filter:                      180  (0.0100396); expected 358.6 (0.02)
Passed Vit filter:                         7  (0.000390429); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.50
# Mc/sec: 741.08
//
Query:       EFC38879.1  [L=440]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.2e-93  313.0   0.0    2.6e-93  312.8   0.0    1.1  1  Gln-synt_C  Glutamine synthetase, catalytic domain
    5.8e-09   35.6   1.3    4.8e-08   32.6   0.0    2.6  3  Gln-synt_N  Glutamine synthetase, beta-Grasp domain


Domain annotation for each model (and alignments):
>> Gln-synt_C  Glutamine synthetase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  312.8   0.0   2.9e-97   2.6e-93       2     345 .]      99     436 ..      98     436 .. 0.94

  Alignments for each domain:
  == domain 1  score: 312.8 bits;  conditional E-value: 2.9e-97
                 T-HHHHHHHHHHHH.HHTTCEEEEEEEEEEEEESEECCCESSEEEEEEE.TB...B.TSS-TTBHCCCCCTCCHHHHHHHHHHHTT--EECCEEECCCT CS
  Gln-synt_C   2 rdPRsvlkralarl.aeeGltvvvgpElEFflfdkeedkeasksllevdseekgrpaekggyfsvapvdeaedlrreivealealgieveashhEvatg 99 
                  d R++l+r+++++ ++++ ++++ +E+EF+l+dke++                +p ++ +y  + p+ +++ ++ ++   +++l+i+v+  hhE++ g
  EFC38879.1  99 SDCRYILERTVEKYlTAKNRRMTFKIEPEFYLLDKETR----------------KPLDQCKYSTMYPFAKGQAFIMDLSLECRRLNIPVQVLHHECGIG 181
                 588****9988765499999**************8877................3467789************************************** PP

                 EEEEEE--EECHHHHHHHHHHHHHHHHHHHHTT-EEE-SSSSSTTS---BEEEEEEEEECTTE....ESSB-TTSGGG.B-HHHHHHHHHHHHHHHHHH CS
  Gln-synt_C 100 QvEinlkfadalkaaDnvvtfKrvvkevArkhgltatFmpKplegdnGsgmHvhlSlwdkdgk....nlfadeddeya.lselarhfigGllkhakalt 193
                 Q+Ei++++ d+lk+aDn+v+fK + + +A++hgl++ FmpKp+ +++Gsg H+h+ ++++d++    n+f + +++++ l + ++++++G+lkh+k +t
  EFC38879.1 182 QYEIEMNHVDLLKQADNLVMFKSLSHVIADRHGLEINFMPKPFRDQAGSGQHIHMRMFKQDETgkeiNAFGNFEGAQDeLGAQGKSYVAGILKHVKGIT 280
                 **********************************************************775422244999998877767******************** PP

                 HHHS-SCCHHHHCSSSTTSSSBEEEESS-TTCSEEEE-.TSGGCSTEEEECEBTTS-HHHHHHHHHHHHHHHHHTT--------S-SSSS-TTTH..TS CS
  Gln-synt_C 194 altaptvnSYkRlvpgyeaPvalawgarNRsallRipa.skekakrvElRlpdasaNPYLalAallaAgldGienklepgepvekdlyelspeer..kg 289
                 a+++pt+nSYkRlv+g+eaP+ ++wg++NR+allR+p  ++++   vE+R+pd  +NPYL++++l+aAg++G+e +le++++ ++++++ s+ee   +g
  EFC38879.1 281 AIANPTINSYKRLVNGFEAPTIACWGYKNRTALLRVPLfTSANDAAVEIRSPDLLSNPYLLFSVLIAAGVQGMEDQLEAPPARTDNVFDYSDEELkkEG 379
                 **************************************999****************************************************998899 PP

                 S-B--SSHHHHHHHHHCSHHHCCSS-HHHHHHHHHHHHHCHHHH.HCT--HHHHHHH CS
  Gln-synt_C 290 ieelPasleeAlealeedellkevlgeevieaylalkraEleel.eeevsdwelery 345
                 +e lP++l eA++++e+d l+kev+ e+ ++ +  +kraE++++ ++ v+dwe+ery
  EFC38879.1 380 LELLPENLLEAIKEFEKDPLMKEVFLEHNFNMFKMAKRAEWDKYvHHCVTDWEFERY 436
                 9*****************************************9956779******98 PP

>> Gln-synt_N  Glutamine synthetase, beta-Grasp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.6   0.0   5.3e-12   4.8e-08      20      66 ..      13      57 ..       5      64 .. 0.87
   2 ?    1.0   0.2      0.04   3.6e+02      53      81 ..      61      89 ..      58      91 .. 0.81
   3 ?   -3.5   0.0         1   8.9e+03       9      22 ..     224     237 ..     218     252 .. 0.62

  Alignments for each domain:
  == domain 1  score: 32.6 bits;  conditional E-value: 5.3e-12
                EEEHHHHHHHTTTT-EEEETTSSTTT------EEEEEEEGGGEEE-S CS
  Gln-synt_N 20 tipadelsedaleegvsFDGSsiegfaeieeSDmlLkPdlstavidP 66
                ti+ + l++d +++g s+DGSs+ gfa +++SD+ L+Pd++ ++ +P
  EFC38879.1 13 TIE-ELLQDDCMKKGASIDGSSV-GFALVNQSDLRLRPDPKAIFELP 57
                444.4447999************.******************99988 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.04
                EEEEEEGGGEEE-SS-SS-..EEEEEEEEE CS
  Gln-synt_N 53 mlLkPdlstavidPfreek.ktarvicdvy 81
                m+ +P ++  v +P+ +++ + ++v+c v+
  EFC38879.1 61 MISNPNPE-SVNCPMLKKPmRRIVVLCHVV 89
                66677754.567999999999******997 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 1
                 EE-SSS-EEEEEEE CS
  Gln-synt_N   9 FtDikgklkhvtip 22 
                 F D  g+ +h+ + 
  EFC38879.1 224 FRDQAGSGQHIHMR 237
                 55666666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (440 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       341  (0.0190195); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.41u 0.25s 00:00:00.65 Elapsed: 00:00:00.42
# Mc/sec: 3159.31
//
Query:       EFC38880.1  [L=565]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-64  211.9  24.8    3.2e-09   37.2   0.3    8.3  8  Sel1      Sel1 repeat
  ------ inclusion threshold ------
      0.011   16.3   1.0         12    6.5   0.2    4.1  4  DUF5344   Family of unknown function (DUF5344)
      0.011   16.4   2.2       0.24   12.1   0.1    3.2  3  TPR_16    Tetratricopeptide repeat
      0.037   14.7   1.3        3.7    8.4   0.0    4.6  5  TPR_6     Tetratricopeptide repeat
        1.1    9.0  11.2        7.3    6.4   0.2    5.1  5  TPR_11    TPR repeat
        8.5    6.4   5.3         73    3.4   0.0    3.9  4  TPR_10    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.2   0.0   3.5e-10     1e-06       2      37 ..      56      89 ..      55      90 .. 0.91
   2 !   37.2   0.3   1.1e-12   3.2e-09       2      37 ..      92     125 ..      91     126 .. 0.91
   3 !   28.1   0.1   7.4e-10   2.2e-06       1      38 []     127     162 ..     127     162 .. 0.94
   4 !   27.7   0.0     1e-09     3e-06       3      38 .]     165     198 ..     164     198 .. 0.93
   5 !   34.5   1.0   7.4e-12   2.2e-08       1      38 []     199     234 ..     199     234 .. 0.95
   6 !   28.7   0.2     5e-10   1.5e-06       1      38 []     235     270 ..     235     270 .. 0.97
   7 !   24.2   0.0   1.3e-08   3.8e-05       3      37 ..     273     305 ..     271     306 .. 0.89
   8 !   14.3   0.0   1.7e-05     0.049       3      29 ..     309     333 ..     307     336 .. 0.93

  Alignments for each domain:
  == domain 1  score: 29.2 bits;  conditional E-value: 3.5e-10
        Sel1  2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37
                e++y LG  + y++G gv+kD ekA+ew+ k AeqG
  EFC38880.1 56 ESYYTLG--CKYMDGSGVEKDSEKAFEWFSKGAEQG 89
                7899999..555***********************9 PP

  == domain 2  score: 37.2 bits;  conditional E-value: 1.1e-12
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 e+ +++G  y+y++Glgv++D++kA+ewy kAA+++
  EFC38880.1  92 ESIHKVG--YFYHHGLGVEQDYKKAMEWYLKAADRN 125
                 67899**..777*********************975 PP

  == domain 3  score: 28.1 bits;  conditional E-value: 7.4e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a ++++ G   ly  G gv kD +k +ewy kAAe+G+
  EFC38880.1 127 AKSQNNIG--VLYRSGEGVAKDLSKSMEWYLKAAENGN 162
                 579*****..877***********************97 PP

  == domain 4  score: 27.7 bits;  conditional E-value: 1e-09
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 A+++ G    y++G gv++D+ k +ewy k+A++G+
  EFC38880.1 165 AQFNIG--ASYDKGVGVEQDKPKSFEWYLKSAKNGY 198
                 9*****..555***********************96 PP

  == domain 5  score: 34.5 bits;  conditional E-value: 7.4e-12
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a A+++++  ++y++  gv+kD +kA+ewy +AA++G+
  EFC38880.1 199 AKAQFNVA--CAYDYAEGVEKDLSKAVEWYLRAAKNGH 234
                 68******..777************************8 PP

  == domain 6  score: 28.7 bits;  conditional E-value: 5e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a+A++++G    y+nG g++kD+ kA+ wy  A e+G+
  EFC38880.1 235 ADAQFNVG--WSYENGEGIEKDYAKAMTWYLTASENGN 270
                 68******..**************************97 PP

  == domain 7  score: 24.2 bits;  conditional E-value: 1.3e-08
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 ++ + G   ly nG+gv+k+ ekA+ewy k Ae++
  EFC38880.1 273 SYTNIG--FLYRNGRGVEKNLEKAFEWYMKGAEKD 305
                 778899..777*****************9999986 PP

  == domain 8  score: 14.3 bits;  conditional E-value: 1.7e-05
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiew 29 
                 ++++++   +y nG gv+kD +kA+ w
  EFC38880.1 309 SQNNVA--NAYSNGYGVEKDLKKALFW 333
                 8999**..777***************9 PP

>> DUF5344  Family of unknown function (DUF5344)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.019        58      48      85 ..     107     144 ..     100     146 .. 0.86
   2 ?   -0.9   0.0      0.83   2.5e+03      45      74 ..     212     241 ..     204     247 .. 0.86
   3 ?   -0.3   0.0      0.56   1.7e+03      47      74 ..     250     277 ..     240     283 .. 0.86
   4 ?    6.5   0.2    0.0041        12      48      75 ..     287     314 ..     263     318 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.019
     DUF5344  48 leeeleellkaYktlllknvedtesaVdslkeaDeala 85 
                 +e++++++++ Y ++   n++++++++  l  + e +a
  EFC38880.1 107 VEQDYKKAMEWYLKAADRNLAKSQNNIGVLYRSGEGVA 144
                 699***********************988876666666 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.83
     DUF5344  45 ineleeeleellkaYktlllknvedtesaV 74 
                 ++ +e++l ++++ Y  + ++  +d++ +V
  EFC38880.1 212 AEGVEKDLSKAVEWYLRAAKNGHADAQFNV 241
                 5668999***********999999998776 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.56
     DUF5344  47 eleeeleellkaYktlllknvedtesaV 74 
                  +e+++ ++++ Y t+ ++  +d++ ++
  EFC38880.1 250 GIEKDYAKAMTWYLTASENGNTDSYTNI 277
                 589*************999998888877 PP

  == domain 4  score: 6.5 bits;  conditional E-value: 0.0041
     DUF5344  48 leeeleellkaYktlllknvedtesaVd 75 
                 +e++le++++ Y++  +k+v++++++V 
  EFC38880.1 287 VEKNLEKAFEWYMKGAEKDVKQSQNNVA 314
                 79************************96 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1      0.21   6.2e+02      48      62 ..     109     123 ..     105     130 .. 0.84
   2 ?    3.9   0.2     0.028        84      19      63 ..     186     232 ..     185     233 .. 0.65
   3 ?   12.1   0.1     8e-05      0.24      14      63 ..     220     268 ..     212     273 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.21
      TPR_16  48 grlaeAaalyraalr 62 
                 +++++A ++y++a++
  EFC38880.1 109 QDYKKAMEWYLKAAD 123
                 799*********985 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.028
      TPR_16  19 aleaalkrdpssPdaaeAllllgdaal.rq...grlaeAaalyraalra 63 
                  +e++lk+++   +   A+++ + a+  +    ++l +A+++y++a+++
  EFC38880.1 186 SFEWYLKSAKNGYA--KAQFNVACAYDyAEgveKDLSKAVEWYLRAAKN 232
                 57777888876644..444444444442224669***********9976 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 8e-05
      TPR_16  14 ddAaaaleaalkrdpssPdaaeAllllgdaalrq....grlaeAaalyraalra 63 
                  +A++ + +a k++     +a+A+++ g+++       +++a+A  +y+ a ++
  EFC38880.1 220 SKAVEWYLRAAKNG-----HADAQFNVGWSYENGegieKDYAKAMTWYLTASEN 268
                 56666677777777.....*************999*************998555 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       5.4   1.6e+04      13      21 ..     109     116 ..      98     124 .. 0.73
   2 ?    0.9   0.0      0.31   9.1e+02       2       2 ..     201     201 ..     165     232 .. 0.52
   3 ?    8.4   0.0    0.0012       3.7       1      21 [.     236     260 ..     236     265 .. 0.89
   4 ?   -3.4   0.0         6   1.8e+04       5      19 ..     276     294 ..     273     296 .. 0.68
   5 ?   -2.0   0.0       2.5   7.4e+03      22      30 ..     539     547 ..     532     553 .. 0.64

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 5.4
                 HHHHHHHHH CS
       TPR_6  13 lgdtdkAle 21 
                 + d+ kA+e
  EFC38880.1 109 Q-DYKKAME 116
                 4.8888887 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.31
                 H CS
       TPR_6   2 A 2  
                 A
  EFC38880.1 201 A 201
                 4 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0012
                 HHHHHHHHHHHHH....HHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtdkAle 21 
                 dA+++ ++sy+++    +d++kA++
  EFC38880.1 236 DAQFNVGWSYENGegieKDYAKAMT 260
                 89**********8899999999987 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 6
                 HHHHHHHHH....HHHHHH CS
       TPR_6   5 klalsyrkl....gdtdkA 19 
                 +++ +yr++    ++ +kA
  EFC38880.1 276 NIGFLYRNGrgveKNLEKA 294
                 6888999875555566665 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 2.5
                 HHHHHHHH- CS
       TPR_6  22 alerlikeY 30 
                 +l+ +ik++
  EFC38880.1 539 ILKAFIKKF 547
                 666666665 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.2    0.0024       7.3       8      38 ..     109     137 ..     108     140 .. 0.81
   2 ?   -0.5   0.1      0.33   9.9e+02      10      22 ..     147     159 ..     145     175 .. 0.67
   3 ?    2.9   0.1     0.029        88       9      22 ..     218     231 ..     216     241 .. 0.87
   4 ?    3.0   0.1     0.027        80       9      22 ..     254     267 ..     251     283 .. 0.73
   5 ?   -3.6   0.0       3.1   9.4e+03       9      18 ..     290     299 ..     289     304 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0024
      TPR_11   8 GkyeeAieaYkkAlkldPdnaeayynLGlay 38 
                 ++y++A+e+Y kA   d + a   +n+G++y
  EFC38880.1 109 QDYKKAMEWYLKAA--DRNLAKSQNNIGVLY 137
                 68***********7..677888888888655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.33
      TPR_11  10 yeeAieaYkkAlk 22 
                 + +++e+Y kA +
  EFC38880.1 147 LSKSMEWYLKAAE 159
                 6678888888865 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.029
      TPR_11   9 kyeeAieaYkkAlk 22 
                 ++ +A+e+Y +A k
  EFC38880.1 218 DLSKAVEWYLRAAK 231
                 6899********76 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.027
      TPR_11   9 kyeeAieaYkkAlk 22 
                 +y +A+++Y +A +
  EFC38880.1 254 DYAKAMTWYLTASE 267
                 899*******9986 PP

  == domain 5  score: -3.6 bits;  conditional E-value: 3.1
      TPR_11   9 kyeeAieaYk 18 
                 ++e+A e+Y 
  EFC38880.1 290 NLEKAFEWYM 299
                 6899999995 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       1.3   3.9e+03      17      29 ..     110     122 ..     109     124 .. 0.83
   2 ?    3.4   0.0     0.025        73       1      13 [.     126     138 ..     126     140 .. 0.89
   3 ?   -1.1   0.0      0.65   1.9e+03       4      14 ..     273     283 ..     272     286 .. 0.88
   4 ?    2.4   0.2      0.05   1.5e+02       4      14 ..     309     319 ..     308     324 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.3
      TPR_10  17 rydeAealleeal 29 
                 +y++A++++ +a 
  EFC38880.1 110 DYKKAMEWYLKAA 122
                 7999****99986 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.025
      TPR_10   1 tAsslnNLanalr 13 
                 +A s+nN+++++r
  EFC38880.1 126 LAKSQNNIGVLYR 138
                 588*********8 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.65
      TPR_10   4 slnNLanalrq 14 
                 s++N++ ++r+
  EFC38880.1 273 SYTNIGFLYRN 283
                 89*******86 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.05
      TPR_10   4 slnNLanalrq 14 
                 s+nN ana+++
  EFC38880.1 309 SQNNVANAYSN 319
                 89*******96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (565 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       802  (0.044732); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 3631.97
//
Query:       EFC38881.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.2e-08   33.5   0.7    7.7e-08   32.7   0.7    1.5  1  EF-hand_7  EF-hand domain pair
    5.8e-08   31.7   0.0     0.0001   21.6   0.0    2.5  2  EF-hand_1  EF hand
    2.3e-06   27.1   0.2      0.001   18.8   0.1    2.5  2  EF-hand_6  EF-hand domain
    2.8e-06   27.7   0.1    0.00015   22.2   0.1    2.4  1  EF-hand_3  EF-hand
     0.0001   21.6   0.1       0.13   11.8   0.0    2.9  3  EF-hand_5  EF hand
  ------ inclusion threshold ------
      0.039   13.8   0.0         11    6.0   0.0    2.8  3  EF-hand_8  EF-hand domain pair


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   0.7   2.6e-11   7.7e-08       2      70 ..      83     177 ..      82     178 .. 0.80

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 2.6e-11
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkifqga.......................gegsklsdee....lellfkefDtdkdG....visfdEFlkl 69 
                 +k++ +F  +D dg+g++++ e+ +ll ++f +                         e+s     e    ++++f+    d+ G    +is ++F+k+
  EFC38881.1  83 DKTHFIFSVYDEDGNGFIERHEMSHLLSCLFNKSlallsdvrkslnlpeyettshkvIEQS-----EidsiVDKCFEQAERDSEGehkgKISKEDFRKW 176
                 68999**************************999*******99999998877554433333.....23334888888886665555566********99 PP

   EF-hand_7  70 y 70 
                 +
  EFC38881.1 177 V 177
                 7 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.0   3.5e-08    0.0001       4      27 ..      87     110 ..      84     112 .. 0.90
   2 !    7.7   0.0   0.00092       2.7      13      26 ..     164     177 ..     163     180 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 3.5e-08
                 HHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   4 eiFrefDkDgdGkIdfeEfkellk 27 
                  iF+++D Dg+G+I++ E+ +ll+
  EFC38881.1  87 FIFSVYDEDGNGFIERHEMSHLLS 110
                 69*****************99986 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00092
                 SSSEEEHHHHHHHH CS
   EF-hand_1  13 gdGkIdfeEfkell 26 
                 + GkI++e+f++++
  EFC38881.1 164 HKGKISKEDFRKWV 177
                 68*********997 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   3.4e-07     0.001       5      27 ..      88     110 ..      86     115 .. 0.91
   2 !    5.7   0.0    0.0054        16      13      25 ..     164     176 ..     151     180 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 3.4e-07
   EF-hand_6   5 aFklfDkdgdGkidaeElrkalr 27 
                 +F  +D dg+G+i ++E+ ++l+
  EFC38881.1  88 IFSVYDEDGNGFIERHEMSHLLS 110
                 8*****************99987 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0054
   EF-hand_6  13 gdGkidaeElrka 25 
                 + Gki++e++rk+
  EFC38881.1 164 HKGKISKEDFRKW 176
                 78*********97 PP

>> EF-hand_3  EF-hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.1   4.9e-08   0.00015       1      86 [.      81     188 ..      81     189 .. 0.65

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 4.9e-08
   EF-hand_3   1 ledKyrylFsli.sdseglldqkklgllL..............eellqvprqvg.EsaaFggsnvepsvrscFeqvs......skkkielehflewlks 77 
                 l+dK +++Fs + +d +g++++++++ lL              ++ l++p++    +++  +s++++ v +cFeq++      +k ki+ e+f +w+ +
  EFC38881.1  81 LQDKTHFIFSVYdEDGNGFIERHEMSHLLsclfnkslallsdvRKSLNLPEYETtSHKVIEQSEIDSIVDKCFEQAErdsegeHKGKISKEDFRKWVYN 179
                 67888888888764555666666655554111111111111112334455533203345677899999*******99999999999************* PP

   EF-hand_3  78 ePqslvWLp 86 
                 +P++l W++
  EFC38881.1 180 QPSVLQWIS 188
                 *******86 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.0   4.5e-05      0.13       5      23 ..      89     107 ..      88     109 .. 0.88
   2 ?   -1.4   0.0      0.65   1.9e+03       2      11 ..     150     159 ..     148     162 .. 0.74
   3 !    6.3   0.0    0.0024       7.1      14      23 ..     166     175 ..     164     178 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.5e-05
                 HHHH-SS-SSCE-HHHHHH CS
   EF-hand_5   5 FqaiDlNgDGkIskeELkt 23 
                 F+  D +g G+I + E   
  EFC38881.1  89 FSVYDEDGNGFIERHEMSH 107
                 999*************876 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.65
                 HHHHHHH-SS CS
   EF-hand_5   2 kdtFqaiDlN 11 
                 +++F+++  +
  EFC38881.1 150 DKCFEQAERD 159
                 459**99776 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0024
                 SCE-HHHHHH CS
   EF-hand_5  14 GkIskeELkt 23 
                 GkIske +++
  EFC38881.1 166 GKISKEDFRK 175
                 ********97 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0    0.0077        23      27      44 ..      84     101 ..      60     112 .. 0.88
   2 ?   -3.6   0.0       3.5     1e+04      25      33 ..     142     150 ..     137     151 .. 0.74
   3 ?    6.0   0.0    0.0037        11       1      12 [.     164     175 ..     164     179 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0077
   EF-hand_8  27 evdilfrefDtdgdGkis 44 
                 + + +f+  D+dg+G i 
  EFC38881.1  84 KTHFIFSVYDEDGNGFIE 101
                 57899*********9875 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 3.5
   EF-hand_8  25 eeevdilfr 33 
                  +e+d++++
  EFC38881.1 142 QSEIDSIVD 150
                 579999987 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0037
   EF-hand_8   1 ekgkItreelrr 12 
                 +kgkI++e++r+
  EFC38881.1 164 HKGKISKEDFRK 175
                 689999999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       690  (0.0384851); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.40u 0.27s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 1418.56
//
Query:       EFC38882.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-60  205.0   0.1    1.8e-60  205.0   0.1    1.0  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  205.0   0.1     1e-64   1.8e-60     211     459 ..      36     282 ..       1     286 [. 0.83

  Alignments for each domain:
  == domain 1  score: 205.0 bits;  conditional E-value: 1e-64
                 HHHHHHHHHHHHHHHHHHHCHCHC.SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCC CS
        p450 211 eavkklkdlldklieerretldsa.kksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlg 308
                  +++k+ + ++++i  r +++++  + + +d l++++ +    ++  +l++ e+  + l+l++aG+dT+s+tlsw++ye  ++P++q+++reEid++l+
  EFC38882.1  36 VHREKFLNKVKEIIALRTREIENGsETQSNDVLSLMIREN-FINN--QLTEGEIYSNSLVLFIAGTDTSSNTLSWFFYEVGRRPDIQKRIREEIDRILP 131
                 3566777777888888888888885445666666666664.4444..6**************************************************9 PP

                 TTTT-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTS.CTESSCTT--TTE CS
        p450 309 dkreptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRFldekg.nskrksfaflPFG 406
                 + + pt +d ++l yl+a+i EtLR hp+v  ++ +e++k ++++  lipk+++v  ++ + ++++++++n++ FdpeRF de+  ++  +++++lPF+
  EFC38882.1 132 NGKAPTLEDYNSLIYLNACIMETLRCHPPVG-SVFKEASKSTHLGPILIPKDSIVHSFIAYSNKNNQIWNNANIFDPERFMDEEYlKKTNSDYSMLPFS 229
                 99*****************************.***************************************************9975557788999*** PP

                 EGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSC.SSEEESSSS CS
        p450 407 aGpRnCiGerlArmelklflatlLqnFevelqpetdpppileks.glllppkpi 459
                 +G R CiG ++  +e   +la++Lq +e+el + ++++++     +++ +p ++
  EFC38882.1 230 MGIRKCIGYKFSLVETCCVLARMLQSYEIELLN-DEVNDPVGYVgQITFRPGNL 282
                 ******************************976.55555544444566665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 1630.64
//
Query:       EFC38883.1  [L=553]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.3e-06   27.1   0.7    9.4e-06   26.0   0.0    2.0  2  VWD         von Willebrand factor type D domain
  ------ inclusion threshold ------
      0.098   12.6   0.1      0.098   12.6   0.1    3.7  4  Ferritin    Ferritin-like domain
       0.61   10.5  13.0       0.51   10.8   0.1    3.4  3  MitMem_reg  Maintenance of mitochondrial structure and functi


Domain annotation for each model (and alignments):
>> VWD  von Willebrand factor type D domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.0   0.0   1.6e-09   9.4e-06       1     128 [.      52     175 ..      52     181 .. 0.64
   2 ?   -3.7   0.8       2.2   1.3e+04      54      71 ..     299     317 ..     278     359 .. 0.52

  Alignments for each domain:
  == domain 1  score: 26.0 bits;  conditional E-value: 1.6e-09
         VWD   1 CsvsgdphitTFDgakytfpgnctYvvlaqdcseqpdefsvnvtvkkedagqenvsclksvkvrvg....dveieltrrnkkvlvngqdvslplvnagk 95 
                 C + gdph  +FD ++++f g  +Y+ laq+++ +     ++v+ ++ ++++ +v   ++v v++g    ++ +  +       ++g +  l + + +k
  EFC38883.1  52 CEALGDPHMLSFDSKRFDFMGLGDYI-LAQSNDDE-----FIVHIRTSKWAAASV--NSNVAVKLGskvfEYDVNAD----VFYIDGVQAPLAVGETKK 138
                 9999**********************.*9997766.....666666666666555..34555555522333333333....445555555552222222 PP

         VWD  96 ....eveilksgfvvvdvppgveltvdgdgssslsvs 128
                     +v++ ++++ +++ + g +lt+++  +++ +++
  EFC38883.1 139 igsgSVNRVNAQTAIATASNGAKLTMSWYRNQAWQAQ 175
                 2234777777787777778888888888776666655 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 2.2
         VWD  54 nvsclksvkvrvg...dveie 71 
                 ++  +k+vk +++   + + +
  EFC38883.1 299 KA--IKKVKSIIKqeeNKTKK 317
                 33..45555555423222222 PP

>> Ferritin  Ferritin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   2.7     0.063   3.8e+02      74     110 ..     291     329 ..     271     353 .. 0.71
   2 ?    0.6   0.1     0.084     5e+02      77     100 ..     339     363 ..     325     374 .. 0.68
   3 ?   12.6   0.1   1.6e-05     0.098      80     128 ..     439     487 ..     424     497 .. 0.85
   4 ?   -0.9   0.1      0.24   1.4e+03      38      87 ..     500     549 ..     490     553 .] 0.50

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.063
                 SSSS.CS.SHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT CS
    Ferritin  74 apke.fg.sveevleaalehekkvteslrelielaeeeg 110
                 +  +  g ++ + ++ ++++e++ t++l+++++ a ++ 
  EFC38883.1 291 KTIKkKGkKAIKKVKSIIKQEENKTKKLKKAAKKAFKKA 329
                 333333447777788899999999999999999888764 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.084
                 S.CSSHHHHHHHHHHHHHHHHHHHH CS
    Ferritin  77 e.fgsveevleaalehekkvteslr 100
                 + f++v+++ + + ++ekkv ++ r
  EFC38883.1 339 KaFKKVKKMAKRVRKSEKKVRKEKR 363
                 2477888888888888888887655 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 1.6e-05
                 SHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
    Ferritin  80 sveevleaalehekkvteslrelielaeeegDpatadfledfleeqeeh 128
                  ++ +++++ ++ kkv ++l+++i+ a++++  + + fl++fl+   + 
  EFC38883.1 439 AARRAIRKLKKQAKKVYKHLKKVIKKAKKNNKSKRVKFLKKFLKRVKKI 487
                 678899*************************************984444 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.24
                 HHHHHHHHHHHHHHHHHHHHTTS....SHHHHHHC-SSSSCSSHHHHHHH CS
    Ferritin  38 deqaeeerehadklaerilalGgtpvltraeleeieapkefgsveevlea 87 
                 d  a     +a +la r ++  +++ + +++ ++ +a++  +++++++++
  EFC38883.1 500 DRMARRVFRQARRLARRAKKATEKAKIFKSKKSQKKAKEANKKAKKAFKK 549
                 55555566666677777666666444444444443222222244444433 PP

>> MitMem_reg  Maintenance of mitochondrial structure and function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   1.7     0.015        91      19      87 ..     209     296 ..     196     302 .. 0.74
   2 ?    2.3   0.6     0.037   2.2e+02      29      66 ..     337     369 ..     305     376 .. 0.76
   3 ?   10.8   0.1   8.6e-05      0.51      29      83 ..     440     493 ..     416     518 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.015
  MitMem_reg  19 s.stlstglnrqyyslkilqerldlikdYlkkveeg..................elpvnheilrnlqkllnllPhleteelekefnve 87 
                 + + l ++l+r+++   +l++   + k+  kkv+++                  ++++ ++i+ +++k+++++   e++el+k ++++
  EFC38883.1 209 AtGILHNHLQRKLTRTVKLKKETPKRKEAAKKVCKKaglnekkhpvawnacvkdTIQSGEKIGAQIGKTIKKVQSAEKKELKKTIKKK 296
                 2477889999999999999999999999999999554444444444444444336888899************999999999988765 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.037
  MitMem_reg  29 qyyslkilqerldlikdYlkkveegelpvnheilrnlq 66 
                  +++ k+++++ +++++  kkv +++     ++lr++q
  EFC38883.1 337 ARKAFKKVKKMAKRVRKSEKKVRKEK-----RLLRKIQ 369
                 5678999999*******999999766.....3555555 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 8.6e-05
  MitMem_reg  29 qyyslkilqerldlikdYlkkveegelpvnhe.ilrnlqkllnllPhleteeleke 83 
                  + ++++l++  +++ + lkkv+++  + n++  ++ l+k+l+++ ++++  ++++
  EFC38883.1 440 ARRAIRKLKKQAKKVYKHLKKVIKKAKKNNKSkRVKFLKKFLKRVKKIAQ--FKRS 493
                 5789*******************9998888889*********99998877..5544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (553 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4602  (0.256679); expected 358.6 (0.02)
Passed bias filter:                      665  (0.0370907); expected 358.6 (0.02)
Passed Vit filter:                       286  (0.0159518); expected 17.9 (0.001)
Passed Fwd filter:                        79  (0.00440627); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.67u 0.38s 00:00:02.04 Elapsed: 00:00:00.60
# Mc/sec: 2788.67
//
Query:       EFC38884.1  [L=582]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.4e-13   49.1  18.5    2.5e-06   27.1   0.5    8.6 10  TPR_2        Tetratricopeptide repeat
    1.1e-09   38.8   0.0    3.6e-05   24.3   0.0    3.8  3  TPR_16       Tetratricopeptide repeat
    3.9e-09   36.7   6.4    2.2e-07   31.1   0.3    5.4  6  TPR_12       Tetratricopeptide repeat
      7e-09   35.8   2.6     0.0082   16.7   0.2    5.7  4  TPR_6        Tetratricopeptide repeat
    7.2e-09   36.0   0.5    0.00011   22.6   0.1    4.7  5  TPR_19       Tetratricopeptide repeat
      4e-08   32.8  25.7    0.00024   21.1   0.5    8.0  9  TPR_8        Tetratricopeptide repeat
    6.1e-07   29.5   0.0     0.0015   18.6   0.0    3.6  3  TPR_9        Tetratricopeptide repeat
    6.4e-07   29.0   3.9     0.0044   16.9   0.0    6.6  8  TPR_7        Tetratricopeptide repeat
    6.5e-07   28.9  25.8      2e-06   27.3   0.5    7.0  8  TPR_1        Tetratricopeptide repeat
    6.6e-07   29.3  10.3    0.00037   20.7   0.0    5.5  6  TPR_17       Tetratricopeptide repeat
    6.6e-05   23.4   0.5        2.3    9.3   0.1    5.5  5  TPR_14       Tetratricopeptide repeat
    7.4e-05   22.5   6.8      0.066   13.1   0.0    6.0  6  TPR_10       Tetratricopeptide repeat
    0.00021   21.5  11.6     0.0021   18.2   0.6    4.4  4  ANAPC3       Anaphase-promoting complex, cyclosome, subunit 3
     0.0039   17.0   0.4       0.02   14.7   0.1    2.2  2  TOM20_plant  Plant specific mitochondrial import receptor sub
  ------ inclusion threshold ------
        1.2    8.9   8.9       0.49   10.1   0.2    4.2  5  TPR_11       TPR repeat
        4.2    7.5   8.7        4.5    7.4   0.1    4.1  4  Fis1_TPR_C   Fis1 C-terminal tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       6.3     7e+03      22      33 ..      83      94 ..      82      95 .. 0.78
   2 ?    3.0   0.0      0.12   1.3e+02       2      31 ..      97     126 ..      96     128 .. 0.88
   3 ?   -0.6   0.0       1.8     2e+03      16      29 ..     151     164 ..     146     169 .. 0.79
   4 ?   -0.7   0.0       1.9   2.2e+03      10      22 ..     184     196 ..     183     203 .. 0.75
   5 ?   -1.0   0.0       2.3   2.6e+03       1      12 [.     222     233 ..     220     253 .. 0.58
   6 ?    6.4   0.2      0.01        11      11      32 ..     312     333 ..     310     335 .. 0.80
   7 ?    1.7   0.0      0.31   3.4e+02       7      26 ..     394     413 ..     392     417 .. 0.89
   8 ?   -0.0   0.1       1.1   1.3e+03      11      21 ..     473     483 ..     471     485 .. 0.84
   9 !   13.7   0.0   4.6e-05     0.051       4      34 .]     499     529 ..     497     529 .. 0.95
  10 !   27.1   0.5   2.3e-09   2.5e-06       3      28 ..     532     557 ..     530     558 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 6.3
       TPR_2 22 eafekAleldPn 33
                e ++  lel+P+
  EFC38884.1 83 EELNDILELNPD 94
                5677789****8 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.12
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleld 31 
                 +al ++ ++y++l d++ A   +ek++e d
  EFC38884.1  97 DALVERSKCYEELSDWKSACVGLEKVVEMD 126
                 68999**************99888888876 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 1.8
       TPR_2  16 dyeeAleafekAle 29 
                 + ++A e+fe+   
  EFC38884.1 151 NVKRATEYFERLFN 164
                 67899*****9865 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 1.9
       TPR_2  10 ayyklgdyeeAle 22 
                 +y++l+ +e+A+ 
  EFC38884.1 184 LYFELNLFEKAIF 196
                 5888999999986 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 2.3
       TPR_2   1 aealynlGlayy 12 
                 ae+l+++G+++ 
  EFC38884.1 222 AELLCRRGNLLV 233
                 567777777665 PP

  == domain 6  score: 6.4 bits;  conditional E-value: 0.01
       TPR_2  11 yyklgdyeeAleafekAleldP 32 
                  +k++dy++A+e+++     +P
  EFC38884.1 312 FLKRKDYKKAIECMDNYYTANP 333
                 5799*********987666666 PP

  == domain 7  score: 1.7 bits;  conditional E-value: 0.31
       TPR_2   7 lGlayyklgdyeeAleafek 26 
                 l  ++++ +++++Al+ +ek
  EFC38884.1 394 LSAIHFYFDRFDDALRECEK 413
                 66789999********9997 PP

  == domain 8  score: -0.0 bits;  conditional E-value: 1.1
       TPR_2  11 yyklgdyeeAl 21 
                  y++g+y  A+
  EFC38884.1 473 FYQQGNYGMAR 483
                 69*****9987 PP

  == domain 9  score: 13.7 bits;  conditional E-value: 4.6e-05
       TPR_2   4 lynlGlayyklgdyeeAleafekAleldPnn 34 
                 l n+++++++ +dye A++  ek le dPn+
  EFC38884.1 499 LSNIADCLIAEKDYEGAIRESEKILEMDPNH 529
                 789**************************97 PP

  == domain 10  score: 27.1 bits;  conditional E-value: 2.3e-09
       TPR_2   3 alynlGlayyklgdyeeAleafekAl 28 
                  l+nlG+ay++l+d+++A+++f+kAl
  EFC38884.1 532 SLFNLGEAYFYLKDLDKARQYFDKAL 557
                 69***********************8 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0063       7.1      20      53 ..      85     115 ..      82     125 .. 0.91
   2 ?    2.1   0.0      0.29   3.2e+02       6      30 ..     311     335 ..     310     345 .. 0.80
   3 !   24.3   0.0   3.2e-08   3.6e-05       7      61 ..     506     557 ..     501     564 .. 0.92

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0063
      TPR_16  20 leaalkrdpssPdaaeAllllgdaalrqgrlaeA 53 
                 l+  l+++   Pd ++Al ++  ++ ++++++ A
  EFC38884.1  85 LNDILELN---PDLVDALVERSKCYEELSDWKSA 115
                 778999**...*******************9987 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.29
      TPR_16   6 aalragdyddAaaaleaalkrdpss 30 
                 ++l+++dy +A++  + +  ++p++
  EFC38884.1 311 YFLKRKDYKKAIECMDNYYTANPKT 335
                 6899999999999999999999665 PP

  == domain 3  score: 24.3 bits;  conditional E-value: 3.2e-08
      TPR_16   7 alragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraal 61 
                 +++ +dy+ A++  e  l++d   P ++ +l++lg+a++ +++l++A++++++al
  EFC38884.1 506 LIAEKDYEGAIRESEKILEMD---PNHHLSLFNLGEAYFYLKDLDKARQYFDKAL 557
                 56678****************...*****************************98 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       4.4     5e+03      43      64 ..      94     115 ..      91     127 .. 0.64
   2 ?   -0.9   0.1       1.8     2e+03       8      19 ..     220     231 ..     216     232 .. 0.82
   3 ?    0.5   0.0      0.68   7.6e+02      49      67 ..     306     324 ..     294     337 .. 0.60
   4 ?   -0.4   0.0       1.3   1.4e+03      44      66 ..     387     409 ..     385     413 .. 0.68
   5 ?    1.3   0.0      0.38   4.2e+02      55      72 ..     473     490 ..     465     495 .. 0.77
   6 !   31.1   0.3   1.9e-10   2.2e-07       6      72 ..     499     557 ..     495     557 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 4.4
      TPR_12  43 ltattlrnLgrlyralgryeeA 64 
                 +++ +l   + +y++l +++ A
  EFC38884.1  94 DLVDALVERSKCYEELSDWKSA 115
                 5566666667777777777666 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.8
      TPR_12   8 nlaavlrrlgry 19 
                 nla++l+r+g++
  EFC38884.1 220 NLAELLCRRGNL 231
                 899999999985 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.68
      TPR_12  49 rnLgrlyralgryeeAlel 67 
                 r++ ++++++++y++A+e 
  EFC38884.1 306 RTMKQYFLKRKDYKKAIEC 324
                 4444444555555555543 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 1.3
      TPR_12  44 tattlrnLgrlyralgryeeAle 66 
                 t+++   L+ ++++++r+++Al+
  EFC38884.1 387 TLQYTASLSAIHFYFDRFDDALR 409
                 55666667777777777777764 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.38
      TPR_12  55 yralgryeeAlelleeal 72 
                 ++++g+y  A+ ++ e++
  EFC38884.1 473 FYQQGNYGMARLFHMESY 490
                 577888888887777776 PP

  == domain 6  score: 31.1 bits;  conditional E-value: 1.9e-10
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72 
                 l+n+a++l + ++y+ A++  ek le+      p+h+l   +l+nLg++y++l+++++A++++ +al
  EFC38884.1 499 LSNIADCLIAEKDYEGAIRESEKILEMD-----PNHHL---SLFNLGEAYFYLKDLDKARQYFDKAL 557
                 569*************************.....99988...9***********************98 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.0     0.013        14       1      28 [.      97     124 ..      97     125 .. 0.94
   2 ?    2.5   0.1      0.25   2.9e+02       9      32 ..     310     334 ..     303     335 .. 0.74
   3 ?    4.4   0.0      0.06        68       5      32 ..     501     528 ..     499     529 .. 0.89
   4 !   16.7   0.2   7.3e-06    0.0082       2      26 ..     532     556 ..     532     558 .. 0.93

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.013
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrklgdtdkAlealerlik 28 
                 dAl  + ++y++l d+  A+  le++++
  EFC38884.1  97 DALVERSKCYEELSDWKSACVGLEKVVE 124
                 7999********99***********986 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.25
                 HHHH.HHHHHHHHHHHHHHHHH-TT CS
       TPR_6   9 syrk.lgdtdkAlealerlikeYPd 32 
                  y+   +d+ kA+e +++  +  P+
  EFC38884.1 310 QYFLkRKDYKKAIECMDNYYTANPK 334
                 5665479********9988777665 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.06
                 HHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   5 klalsyrklgdtdkAlealerlikeYPd 32 
                 ++a ++++ +d++ A++  e++++  P+
  EFC38884.1 501 NIADCLIAEKDYEGAIRESEKILEMDPN 528
                 69******99*******99999988887 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 7.3e-06
                 HHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerl 26 
                 +l++l+++y+ l+d dkA++++++ 
  EFC38884.1 532 SLFNLGEAYFYLKDLDKARQYFDKA 556
                 59*********99*********986 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.033        37      14      57 ..      85     128 ..      82     132 .. 0.89
   2 ?   -1.3   0.0         3   3.3e+03      31      47 ..     181     197 ..     175     202 .. 0.84
   3 ?    1.6   0.0      0.35     4e+02       2      23 ..     313     334 ..     300     347 .. 0.74
   4 ?   -1.3   0.0       2.9   3.2e+03       9      33 ..     457     483 ..     455     498 .. 0.65
   5 !   22.6   0.1     1e-07   0.00011       1      51 [.     506     556 ..     506     557 .. 0.95

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.033
      TPR_19  14 leqalqedpknaearllLAeallalgqldeAealLdalpeedpd 57 
                 l  +l+ +p+  +a+    +++ +l +++ A   L+++ e+d+ 
  EFC38884.1  85 LNDILELNPDLVDALVERSKCYEELSDWKSACVGLEKVVEMDRP 128
                 678999*************************9999999998876 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 3
      TPR_19  31 LAeallalgqldeAeal 47 
                 L  ++++l+ +++A+ +
  EFC38884.1 181 LYSLYFELNLFEKAIFI 197
                 56689*********876 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.35
      TPR_19   2 laegdyaeAlalleqalqedpk 23 
                 l+++dy  A++ + + ++++pk
  EFC38884.1 313 LKRKDYKKAIECMDNYYTANPK 334
                 5566666666666666666665 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 2.9
      TPR_19   9 eAlalleqalqedpk..naearllLAe 33 
                 eA +++ ++l++ p+  ++   +++A+
  EFC38884.1 457 EAKKFYPKILKDIPEyfYQQGNYGMAR 483
                 566666666666666555555555555 PP

  == domain 5  score: 22.6 bits;  conditional E-value: 1e-07
      TPR_19   1 llaegdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdal 51 
                 l+ae+dy+ A++  e++l+ dp++   + +L ea++ l++ld+A++  d++
  EFC38884.1 506 LIAEKDYEGAIRESEKILEMDPNHHLSLFNLGEAYFYLKDLDKARQYFDKA 556
                 799*******************************************98876 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       9.5   1.1e+04      21      33 ..      82      94 ..      79      94 .. 0.83
   2 ?   -0.6   0.0       1.8     2e+03       3      32 ..      98     127 ..      96     128 .. 0.72
   3 ?    3.1   0.2      0.12   1.4e+02       9      29 ..     183     203 ..     177     208 .. 0.84
   4 ?   -2.7   0.0       8.7   9.8e+03       1      27 [.     222     249 ..     222     254 .. 0.58
   5 ?    0.9   0.1      0.63   7.1e+02       6      31 ..     262     287 ..     257     290 .. 0.80
   6 ?    6.3   0.3     0.011        13      12      33 ..     313     334 ..     310     335 .. 0.88
   7 ?   -1.2   0.1       2.9   3.2e+03       4      32 ..     434     463 ..     433     466 .. 0.61
   8 !   13.3   0.1   6.6e-05     0.074       6      34 .]     501     529 ..     499     529 .. 0.96
   9 !   21.1   0.5   2.1e-07   0.00024       3      28 ..     532     557 ..     531     557 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 9.5
                HHHHHHHHHHHHH CS
       TPR_8 21 keyyekaleldpd 33
                +e ++  lel+pd
  EFC38884.1 82 IEELNDILELNPD 94
                78899999***97 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.8
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldp 32 
                 a++  +++y++l d ++A   +ek++e+d+
  EFC38884.1  98 ALVERSKCYEELSDWKSACVGLEKVVEMDR 127
                 666677777777777777777888888875 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.12
                 HHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   9 siylklgdyeeAkeyyekale 29 
                 s+y++l+ +e+A+    + ++
  EFC38884.1 183 SLYFELNLFEKAIFIATEGIK 203
                 79***********98877776 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 8.7
                 CCHHHHHHHHH.HHTT-HHHHHHHHHHH CS
       TPR_8   1 aeayynlgsiy.lklgdyeeAkeyyeka 27 
                 ae++++ g+++  k + ++  ++ + +a
  EFC38884.1 222 AELLCRRGNLLvTKYNMMDRGQKDLDRA 249
                 5777888887744444455555555555 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.63
                 HHHHHHHHTT-HHHHHHHHHHHHHHH CS
       TPR_8   6 nlgsiylklgdyeeAkeyyekaleld 31 
                 ++ +  +k+++++ + ++ye + e +
  EFC38884.1 262 LMLDSFEKKNNHDLMLKTYELVKEFE 287
                 56677899************887765 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.011
                 HHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8  12 lklgdyeeAkeyyekaleldpd 33 
                 lk +dy++A+e++  + +++p+
  EFC38884.1 313 LKRKDYKKAIECMDNYYTANPK 334
                 6789**********99999997 PP

  == domain 7  score: -1.2 bits;  conditional E-value: 2.9
                 HHHHH.HHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   4 yynlg.siylklgdyeeAkeyyekaleldp 32 
                 yy+++   ++k+g+ +   e+ ++a +  p
  EFC38884.1 434 YYLIStFSHMKKGNENLILEFAKEAKKFYP 463
                 666664455777777766666666666555 PP

  == domain 8  score: 13.3 bits;  conditional E-value: 6.6e-05
                 HHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   6 nlgsiylklgdyeeAkeyyekaleldpdn 34 
                 n++++++  +dye A+   ek le+dp++
  EFC38884.1 501 NIADCLIAEKDYEGAIRESEKILEMDPNH 529
                 89*************************97 PP

  == domain 9  score: 21.1 bits;  conditional E-value: 2.1e-07
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekal 28 
                 +++nlg +y+ l+d+++A +y+ kal
  EFC38884.1 532 SLFNLGEAYFYLKDLDKARQYFDKAL 557
                 589*********************97 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0     0.014        16      21      59 ..      88     126 ..      80     135 .. 0.88
   2 ?   -0.1   0.0      0.95   1.1e+03       4      26 ..     311     333 ..     308     339 .. 0.65
   3 !   18.6   0.0   1.4e-06    0.0015       4      56 ..     505     557 ..     502     571 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.014
       TPR_9  21 llllaPddpeerrdRGlllaqlGclsaAladLeaylala 59 
                 +l l+Pd ++ + +R  ++++l +++ A   Le  ++++
  EFC38884.1  88 ILELNPDLVDALVERSKCYEELSDWKSACVGLEKVVEMD 126
                 89**************************99999888876 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.95
       TPR_9   4 iaireedweralavverllllaP 26 
                   + ++d+ +a+++ +     +P
  EFC38884.1 311 YFLKRKDYKKAIECMDNYYTANP 333
                 55677888888888776554444 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 1.4e-06
       TPR_9   4 iaireedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeayl 56 
                 ++i e+d+e a++ +e +l ++P+++  ++  G +++ l +l +A++ ++ +l
  EFC38884.1 505 CLIAEKDYEGAIRESEKILEMDPNHHLSLFNLGEAYFYLKDLDKARQYFDKAL 557
                 6899*********************************************9887 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       1.4   1.6e+03       7      19 ..     104     116 ..      98     131 .. 0.74
   2 ?   -2.8   0.0       7.8   8.8e+03      16      24 ..     153     161 ..     151     167 .. 0.84
   3 ?   -0.2   0.0       1.1   1.3e+03       7      19 ..     183     195 ..     179     195 .. 0.91
   4 ?   -0.2   0.1       1.2   1.4e+03       4      14 ..     220     230 ..     219     231 .. 0.90
   5 ?    1.1   0.0      0.47   5.2e+02      11      21 ..     314     324 ..     309     327 .. 0.82
   6 ?   -1.6   0.0       3.3   3.6e+03       7      24 ..     396     413 ..     392     422 .. 0.77
   7 ?    2.5   0.0      0.16   1.8e+02       2      25 ..     499     522 ..     499     529 .. 0.80
   8 !   16.9   0.0     4e-06    0.0044       1      35 [.     532     566 ..     532     567 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.4
       TPR_7   7 rlysrlGdyeeAi 19 
                  +y++l d++ A 
  EFC38884.1 104 KCYEELSDWKSAC 116
                 6899*****9986 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 7.8
       TPR_7  16 eeAielyeq 24 
                 ++A e++e+
  EFC38884.1 153 KRATEYFER 161
                 78999**99 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 1.1
       TPR_7   7 rlysrlGdyeeAi 19 
                 +ly++l+ +e+Ai
  EFC38884.1 183 SLYFELNLFEKAI 195
                 689*********8 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 1.2
       TPR_7   4 nLarlysrlGd 14 
                 nLa+l +r+G+
  EFC38884.1 220 NLAELLCRRGN 230
                 9*******997 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.47
       TPR_7  11 rlGdyeeAiel 21 
                 ++ dy++Aie+
  EFC38884.1 314 KRKDYKKAIEC 324
                 5669******8 PP

  == domain 6  score: -1.6 bits;  conditional E-value: 3.3
       TPR_7   7 rlysrlGdyeeAielyeq 24 
                  +++   ++++A++ +e+
  EFC38884.1 396 AIHFYFDRFDDALRECEK 413
                 678888899999998887 PP

  == domain 7  score: 2.5 bits;  conditional E-value: 0.16
       TPR_7   2 LlnLarlysrlGdyeeAielyeqs 25 
                 L+n+a++  ++ dye Ai+  e+ 
  EFC38884.1 499 LSNIADCLIAEKDYEGAIRESEKI 522
                 78****************866664 PP

  == domain 8  score: 16.9 bits;  conditional E-value: 4e-06
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLaltkdpeda 35 
                 +L+nL+++y+ l d ++A +++ ++L+  ++++++
  EFC38884.1 532 SLFNLGEAYFYLKDLDKARQYFDKALVGVNEDNGM 566
                 79**********************99888888775 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       6.5   7.3e+03      28      33 ..      89      94 ..      88      95 .. 0.88
   2 ?    1.5   0.0      0.27   3.1e+02      10      21 ..     184     195 ..     183     198 .. 0.92
   3 ?   -0.4   0.0       1.1   1.2e+03       1      11 [.     222     232 ..     222     234 .. 0.88
   4 ?    5.7   0.3     0.012        14      11      23 ..     312     324 ..     310     324 .. 0.89
   5 ?   -3.0   0.1         7   7.9e+03      15      26 ..     402     413 ..     397     413 .. 0.71
   6 ?   -1.7   0.2       2.8   3.1e+03      11      20 ..     473     482 ..     472     483 .. 0.85
   7 !    8.4   0.0    0.0017       1.9       4      34 .]     499     529 ..     497     529 .. 0.94
   8 !   27.3   0.5   1.8e-09     2e-06       3      28 ..     532     557 ..     530     558 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 6.5
                HHHSTT CS
       TPR_1 28 LelnPn 33
                LelnP+
  EFC38884.1 89 LELNPD 94
                9****8 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.27
                 HHHHTT-HHHHH CS
       TPR_1  10 ayfklgkydeAl 21 
                 +yf+l+ +++A+
  EFC38884.1 184 LYFELNLFEKAI 195
                 79*********9 PP

  == domain 3  score: -0.4 bits;  conditional E-value: 1.1
                 HHHHHHHHHHH CS
       TPR_1   1 akalynlGnay 11 
                 a+ l+++Gn++
  EFC38884.1 222 AELLCRRGNLL 232
                 789******86 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.012
                 HHHTT-HHHHHHH CS
       TPR_1  11 yfklgkydeAley 23 
                 ++k ++y++A+e+
  EFC38884.1 312 FLKRKDYKKAIEC 324
                 6899*******99 PP

  == domain 5  score: -3.0 bits;  conditional E-value: 7
                 T-HHHHHHHHHH CS
       TPR_1  15 gkydeAleyyek 26 
                  ++d+Al  +ek
  EFC38884.1 402 DRFDDALRECEK 413
                 689999986665 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 2.8
                 HHHTT-HHHH CS
       TPR_1  11 yfklgkydeA 20 
                 ++++g+y  A
  EFC38884.1 473 FYQQGNYGMA 482
                 699****877 PP

  == domain 7  score: 8.4 bits;  conditional E-value: 0.0017
                 HHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   4 lynlGnayfklgkydeAleyyekALelnPnn 34 
                 l n++ ++   ++y+ A+   ek Le +Pn+
  EFC38884.1 499 LSNIADCLIAEKDYEGAIRESEKILEMDPNH 529
                 68***************************96 PP

  == domain 8  score: 27.3 bits;  conditional E-value: 1.8e-09
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekAL 28 
                 +l+nlG ayf+l+++d+A +y++kAL
  EFC38884.1 532 SLFNLGEAYFYLKDLDKARQYFDKAL 557
                 689**********************9 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0    0.0036         4       5      32 ..      88     115 ..      84     116 .. 0.88
   2 ?   -0.9   0.1       2.6   2.9e+03      16      24 ..     175     183 ..     173     195 .. 0.71
   3 ?    2.1   0.1      0.27   3.1e+02      18      29 ..     220     231 ..     218     249 .. 0.86
   4 ?   -0.8   0.1       2.4   2.7e+03       2       8 ..     318     324 ..     311     328 .. 0.80
   5 ?   -2.4   0.0       7.5   8.4e+03      23      33 ..     473     483 ..     471     483 .. 0.82
   6 !   20.7   0.0   3.3e-07   0.00037       3      34 .]     520     551 ..     520     551 .. 0.97

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0036
      TPR_17   5 aleldPnnadaynnLAelllknGdlmtA 32 
                  lel+P+ +da+ ++ ++++++ d++ A
  EFC38884.1  88 ILELNPDLVDALVERSKCYEELSDWKSA 115
                 69******************99988766 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 2.6
      TPR_17  16 ynnLAelll 24 
                 ++++A+l++
  EFC38884.1 175 FFYYATLYS 183
                 799999998 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.27
      TPR_17  18 nLAelllknGdl 29 
                 nLAell+++G+l
  EFC38884.1 220 NLAELLCRRGNL 231
                 899999988874 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 2.4
      TPR_17   2 ylkalel 8  
                 y+ka+e+
  EFC38884.1 318 YKKAIEC 324
                 7888887 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 7.5
      TPR_17  23 llknGdlmtAr 33 
                 ++++G++++Ar
  EFC38884.1 473 FYQQGNYGMAR 483
                 6789****997 PP

  == domain 6  score: 20.7 bits;  conditional E-value: 3.3e-07
      TPR_17   3 lkaleldPnnadaynnLAelllknGdlmtArq 34 
                 +k le dPn+  +++nL+e++  ++dl++Arq
  EFC38884.1 520 EKILEMDPNHHLSLFNLGEAYFYLKDLDKARQ 551
                 689***************************98 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.54   6.1e+02      21      41 ..      82     102 ..      79     105 .. 0.84
   2 ?    2.1   0.0       0.4   4.4e+02       3      33 ..     304     334 ..     302     344 .. 0.84
   3 ?   -1.6   0.0       6.5   7.2e+03      10      25 ..     397     412 ..     390     419 .. 0.75
   4 ?    4.2   0.0     0.088        98       8      43 ..     503     538 ..     497     539 .. 0.86
   5 !    9.3   0.1     0.002       2.3       7      29 ..     536     558 ..     532     570 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.54
      TPR_14  21 iallrralalaPddaeawlll 41 
                 i+ l+++l+l+Pd  +a+ + 
  EFC38884.1  82 IEELNDILELNPDLVDALVER 102
                 6789*********99998765 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.4
      TPR_14   3 allalaeallalGdpdeAiallrralalaPd 33 
                 +++ + +++l + d+++Ai++ + +  ++P+
  EFC38884.1 304 LHRTMKQYFLKRKDYKKAIECMDNYYTANPK 334
                 677788999***********99999888887 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 6.5
      TPR_14  10 allalGdpdeAiallr 25 
                 +++  +++d+A++ ++
  EFC38884.1 397 IHFYFDRFDDALRECE 412
                 5666678999988776 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.088
      TPR_14   8 aeallalGdpdeAiallrralalaPddaeawlllaq 43 
                 a+ l a  d+++Ai+  +++l+ +P++   ++ l++
  EFC38884.1 503 ADCLIAEKDYEGAIRESEKILEMDPNHHLSLFNLGE 538
                 56688999******************9988887775 PP

  == domain 5  score: 9.3 bits;  conditional E-value: 0.002
      TPR_14   7 laeallalGdpdeAiallrrala 29 
                 l+ea++ l d+d+A++++++al 
  EFC38884.1 536 LGEAYFYLKDLDKARQYFDKALV 558
                 89******************985 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.1      0.52   5.9e+02       6      17 ..     219     230 ..     218     231 .. 0.90
   2 ?    0.9   0.0       0.4   4.5e+02      10      31 ..     303     324 ..     297     326 .. 0.87
   3 ?    1.3   0.0      0.31   3.5e+02       7      27 ..     393     413 ..     387     413 .. 0.86
   4 ?   -1.0   0.0       1.6   1.8e+03      13      30 ..     474     491 ..     472     496 .. 0.76
   5 ?    3.1   0.1      0.08        90      21      40 ..     508     529 ..     507     531 .. 0.93
   6 !   13.1   0.0   5.9e-05     0.066       7      29 ..     535     557 ..     532     558 .. 0.96

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.52
      TPR_10   6 nNLanalrqrgr 17 
                  NLa +l++rg+
  EFC38884.1 219 DNLAELLCRRGN 230
                 6**********8 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.4
      TPR_10  10 nalrqrgrydeAealleealai 31 
                 n++r +++y   ++++++a+++
  EFC38884.1 303 NLHRTMKQYFLKRKDYKKAIEC 324
                 78999999999*********97 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.31
      TPR_10   7 NLanalrqrgrydeAeallee 27 
                  L+++++   r+d+A++ +e+
  EFC38884.1 393 SLSAIHFYFDRFDDALRECEK 413
                 69999***********99886 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.6
      TPR_10  13 rqrgrydeAealleeala 30 
                 +q+g+y  A+ ++ e+++
  EFC38884.1 474 YQQGNYGMARLFHMESYN 491
                 89****999988877766 PP

  == domain 5  score: 3.1 bits;  conditional E-value: 0.08
      TPR_10  21 AealleealairrrllG..pdH 40 
                 Ae+++e a++  +++l+  p+H
  EFC38884.1 508 AEKDYEGAIRESEKILEmdPNH 529
                 9****************99998 PP

  == domain 6  score: 13.1 bits;  conditional E-value: 5.9e-05
      TPR_10   7 NLanalrqrgrydeAealleeal 29 
                 NL+ a++ ++++d+A++++++al
  EFC38884.1 535 NLGEAYFYLKDLDKARQYFDKAL 557
                 9********************98 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       1.7   1.9e+03      27      43 ..     100     116 ..      85     126 .. 0.69
   2 ?    2.7   0.1      0.13   1.5e+02       1      48 [.     148     200 ..     148     208 .. 0.69
   3 ?    4.2   1.2     0.045        50      30      56 ..     309     336 ..     243     348 .. 0.77
   4 !   18.2   0.6   1.9e-06    0.0021      16      81 ..     490     555 ..     475     556 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.7
                 HHHHHHHHHTT-HHHHH CS
      ANAPC3  27 yllAlclylngqykrAy 43 
                    ++c+ +++++k+A+
  EFC38884.1 100 VERSKCYEELSDWKSAC 116
                 44577888888888886 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.13
                 HTT-HHHHHHHHHHHH.HHH--HHH..HHHHHH...HHHHTT-HHHHHHHHHC CS
      ANAPC3   1 dqnnyknAiflaerllaaetesped..ayllAl...clylngqykrAyellrk 48 
                 +++n k A  ++erl++  ++++     +++A     +++++ +++A+ ++ +
  EFC38884.1 148 ENYNVKRATEYFERLFNIVSNDSVQipFFYYATlysLYFELNLFEKAIFIATE 200
                 58899999999999997666666555534444311157888889999888765 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.045
                 HHHHHHTT-HHHHHHHHHCT.SHHHC-H CS
      ANAPC3  30 AlclylngqykrAyellrka.klnsksl 56 
                  + ++++++yk+A+e  +++   n+k+l
  EFC38884.1 309 KQYFLKRKDYKKAIECMDNYyTANPKTL 336
                 578899999****999999977777776 PP

  == domain 4  score: 18.2 bits;  conditional E-value: 1.9e-06
                 H.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH-S CS
      ANAPC3  16 laaetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaLek 81 
                 +  e++ +ed+   A cl   ++y+ A++  +k  + +++++ +++ ++++++ Lk +++A++ ++k
  EFC38884.1 490 Y-NESKELEDLSNIADCLIAEKDYEGAIRESEKIlEMDPNHHLSLFNLGEAYFYLKDLDKARQYFDK 555
                 3.578889999999************************************************99987 PP

>> TOM20_plant  Plant specific mitochondrial import receptor subunit TOM20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       1.4   1.5e+03      46      72 ..      73      99 ..      68     110 .. 0.83
   2 !   14.7   0.1   1.8e-05      0.02      38     100 ..     499     557 ..     491     563 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHHHHHHHHH-TT-HHHH CS
  TOM20_plant 46 eakqmiqdaiskleeallidPkkhdal 72
                 e k m ++ i  l++ l ++P   dal
   EFC38884.1 73 EVKMMKRKRIEELNDILELNPDLVDAL 99
                 667888899************999998 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.8e-05
                  HHHHS-HHHHHHHHHHHHHHHHHHHHH-TT-HHHHHHHHHHHHHHHHH---HHHHHHHHHHHH CS
  TOM20_plant  38 lsqfqsvaeakqmiqdaiskleeallidPkkhdalWcignaytsfafltpdeeeakenfekat 100
                  ls       a +  + ai   e+ l +dP+ h +l+ +g+ay    f+ +d ++a+++f+ka 
   EFC38884.1 499 LSNIADCLIAEKDYEGAIRESEKILEMDPNHHLSLFNLGEAY----FYLKDLDKARQYFDKAL 557
                  44444444466777889************************9....899************95 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0       0.5   5.6e+02      21      32 ..      89     100 ..      82     109 .. 0.75
   2 ?   -2.7   0.0       4.4   4.9e+03       4      14 ..     185     195 ..     184     195 .. 0.89
   3 ?   -0.1   0.0      0.67   7.5e+02       7      15 ..     315     323 ..     312     325 .. 0.59
   4 ?   -1.9   0.3       2.4   2.7e+03       4      11 ..     473     480 ..     472     483 .. 0.83
   5 ?   10.1   0.2   0.00044      0.49       5      39 ..     507     541 ..     503     557 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.5
      TPR_11  21 lkldPdnaeayy 32 
                 l+l+Pd ++a+ 
  EFC38884.1  89 LELNPDLVDALV 100
                 89*******975 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 4.4
      TPR_11   4 yyeqGkyeeAi 14 
                 y+e++ +e+Ai
  EFC38884.1 185 YFELNLFEKAI 195
                 99999999998 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.67
      TPR_11   7 qGkyeeAie 15 
                 + +y++Aie
  EFC38884.1 315 RKDYKKAIE 323
                 555555555 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 2.4
      TPR_11   4 yyeqGkye 11 
                 +y+qG+y 
  EFC38884.1 473 FYQQGNYG 480
                 89***996 PP

  == domain 5  score: 10.1 bits;  conditional E-value: 0.00044
      TPR_11   5 yeqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                  +  +ye+Ai + +k l+ dP+    ++nLG+ay+
  EFC38884.1 507 IAEKDYEGAIRESEKILEMDPNHHLSLFNLGEAYF 541
                 67789*****************************8 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.2       2.5   2.8e+03      13      26 ..     314     327 ..     313     334 .. 0.82
   2 ?   -2.4   0.0       4.9   5.4e+03      12      22 ..     474     484 ..     474     486 .. 0.84
   3 ?    2.9   0.0       0.1   1.2e+02      15      34 ..     510     529 ..     509     530 .. 0.92
   4 ?    7.4   0.1     0.004       4.5       4      28 ..     533     557 ..     531     567 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2.5
                 HHT-HHHHHHHHHH CS
  Fis1_TPR_C  13 klgeYseArryvda 26 
                 k ++Y++A +++d 
  EFC38884.1 314 KRKDYKKAIECMDN 327
                 7799****999875 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 4.9
                 HHHT-HHHHHH CS
  Fis1_TPR_C  12 yklgeYseArr 22 
                 y +g+Y +Ar 
  EFC38884.1 474 YQQGNYGMARL 484
                 7799****996 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.1
                 T-HHHHHHHHHHHHHHTTS- CS
  Fis1_TPR_C  15 geYseArryvdalLeiEPen 34 
                 ++Y+ A r  + +Le++P+ 
  EFC38884.1 510 KDYEGAIRESEKILEMDPNH 529
                 79****************85 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.004
                 HHHHHHHHHHHT-HHHHHHHHHHHH CS
  Fis1_TPR_C   4 lYylAlGhyklgeYseArryvdalL 28 
                 l+ l  +++ l++ ++Ar+y d  L
  EFC38884.1 533 LFNLGEAYFYLKDLDKARQYFDKAL 557
                 8999*****************9877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (582 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       900  (0.050198); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 3408.24
//
Query:       EFC38885.1  [L=145]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.6   0.0       0.16   12.1   0.0    1.5  1  DUF2314   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF2314  Uncharacterized protein conserved in bacteria (DUF2314)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   8.9e-06      0.16      52      96 ..      61     105 ..      28     117 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 8.9e-06
     DUF2314  52 pkvEhmWiedvefdgekikGvlanePeeltnvkegdkveiklnei 96 
                 ++ E +W++ ++++ +++ G++ n+  + ++ + gd + +k+ne+
  EFC38885.1  61 KIEERFWVKVLKVSAKYLIGIIDNDLVSGQDYTLGDLILFKKNEV 105
                 56899*************************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (145 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       706  (0.0393775); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.52
# Mc/sec: 834.66
//
Query:       EFC38886.1  [L=142]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (142 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       770  (0.0429472); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 889.96
//
Query:       EFC38887.1  [L=229]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.7e-51  172.6   0.1      6e-51  172.3   0.1    1.1  1  Ras          Ras family
    1.8e-17   63.6   0.0    2.9e-17   63.0   0.0    1.3  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    1.3e-11   44.2   0.0    1.6e-11   44.0   0.0    1.1  1  Arf          ADP-ribosylation factor family
    1.1e-05   25.1   0.0    2.3e-05   24.0   0.0    1.5  1  GTP_EFTU     Elongation factor Tu GTP binding domain
  ------ inclusion threshold ------
      0.048   12.8   0.1        3.7    6.6   0.1    2.2  2  G-alpha      G-protein alpha subunit
      0.049   13.7   0.0      0.082   13.0   0.0    1.4  1  MMR_HSR1     50S ribosome-binding GTPase
       0.12   12.3   0.4        8.4    6.3   0.4    2.3  2  RsgA_GTPase  RsgA GTPase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  172.3   0.1   2.3e-54     6e-51       1     161 [.      10     173 ..      10     174 .. 0.98

  Alignments for each domain:
  == domain 1  score: 172.3 bits;  conditional E-value: 2.3e-54
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K+v++G+++vGK++++++f+k++Fk  y++Ti +d yt + +vd+k v+++++DTAGqeef+++r++y+r+++g++lvy+it+++sfe+vk+++ ++ r
  EFC38887.1  10 KFVMLGSGGVGKSAVTIQFIKKEFKFGYDPTI-EDAYTVQRTVDNKPVSISLLDTAGQEEFTAMRDQYMREGDGFILVYSITDASSFEEVKDIYGQLCR 107
                 89******************************.****************************************************************** PP

                 HST...TTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHHH CS
         Ras 100 vae...envpivLvGnKvDleekravsteegeelakelg.lkfletSAktnenveeafeellreil 161
                   +   e +p++++GnK+Dlee+r++s++ege +ak++  +kf+etSA  n n+e+a+++l+r+++
  EFC38887.1 108 SRDvgeEGIPVCILGNKIDLEEERVISYKEGEGFAKQFAkCKFFETSAYRNINIENAYDALVRTVR 173
                 99999999*****************************999***********************986 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.0   0.0   1.1e-20   2.9e-17       1     120 []      10     127 ..      10     127 .. 0.83

  Alignments for each domain:
  == domain 1  score: 63.0 bits;  conditional E-value: 1.1e-20
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlk 96 
                 K v++G +gvGK+    +f++++f+  +++ti   ++ +++     v+n    k v++++ DtaGqe+f ++++ y+re + +ilvy    ++s+e++k
  EFC38887.1  10 KFVMLGSGGVGKSAVTIQFIKKEFKFGYDPTIEDAYTVQRT-----VDN----KPVSISLLDTAGQEEFTAMRDQYMREGDGFILVYSitdASSFEEVK 99 
                 89*******************************99876654.....322....5799*****************************9754366788999 PP

                 HHHHHHHHH...CSS.S-EEEEEE-TTT CS
         Roc  97 eWlkelkkv...agk.spvilvgnkiDl 120
                 + + +l +    +++ +pv+++gnkiDl
  EFC38887.1 100 DIYGQLCRSrdvGEEgIPVCILGNKIDL 127
                 8777775542223332699*******95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.0   6.2e-15   1.6e-11      11     172 ..       5     169 ..       1     172 [. 0.80

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 6.2e-15
                 .TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSS..EEE.EEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHH CS
         Arf  11 kkkelrilllGLDnaGKtTilkklkleelvt.tvPTig..fnv.eeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLk 105
                 ++ e++ ++lG  + GK+ +  ++ ++e++    PTi   ++v +++  k +++++ D  Gqe+   + ++Y+++ d+ i v   +d + +ee k+   
  EFC38887.1   5 QRDEMKFVMLGSGGVGKSAVTIQFIKKEFKFgYDPTIEdaYTVqRTVDNKPVSISLLDTAGQEEFTAMRDQYMREGDGFILVYSITDASSFEEVKDIYG 103
                 4679********************9999987589**9733344268999************************************************** PP

                 HHCTSGCCT..TSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHH CS
         Arf 106 alleeeelk..evallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewls 172
                 +l +++++    +++ +l+NK+Dl+e      ++ + g    k+  k + +++sa ++ +++++ + l+
  EFC38887.1 104 QLCRSRDVGeeGIPVCILGNKIDLEEER---VISYKEGEGFAKQFAKCKFFETSAYRNINIENAYDALV 169
                 ****999864489***********9753...33333333333444566666777776666666666665 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   9.1e-09   2.3e-05      65     192 ..      50     172 ..      21     174 .. 0.74

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 9.1e-09
                 T.TCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB.....STHHHHHHH..HHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  65 k.etkkylinliDtPGHvdFskevirglrvlDgavlvvdaveG.....vepqteevl..rlalkegvpiivfiNKmDrlkaelkeiveevkqklsrkee 155
                 + + k   i+l+Dt G ++F+    + +r  Dg +lv ++++      v+    ++   r + +eg+p++++ NK+D  ++++   +e     +     
  EFC38887.1  50 TvDNKPVSISLLDTAGQEEFTAMRDQYMREGDGFILVYSITDAssfeeVKDIYGQLCrsRDVGEEGIPVCILGNKIDLEEERVISYKEGEG--F----- 141
                 24789999********************************9665444444444444311456689999**********9998877776655..6..... PP

                 HHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHHHHHHS CS
    GTP_EFTU 156 klekygekgekevpvvfgSalkgegvktllealvell 192
                   +++      +++++ +Sa+++ ++++  +alv+ +
  EFC38887.1 142 -AKQF-----AKCKFFETSAYRNINIENAYDALVRTV 172
                 .2222.....246799999999999999999998866 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.1    0.0015       3.7      18      43 ..       5      28 ..       1      53 [. 0.76
   2 ?    4.6   0.0     0.006        15     248     300 ..      92     156 ..      32     193 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0015
                XXE..EEEEEEEESTTSSHHHHHHHH CS
     G-alpha 18 rkkkrevkllllGqseSGKsTilkql 43
                +  + e+k+++lG+++ GKs +  q+
  EFC38887.1  5 Q--RDEMKFVMLGSGGVGKSAVTIQF 28
                3..4599*************996665 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.006
                 SBHHHHHHHHHHCCCC-GGG..TTSEEEEEEE-HHHHHHHC...CCS.-GGGCCTT--......H CS
     G-alpha 248 vnrleeslklFkeicnnkll..kntpiiLflnKlDileeKl...kkg.klskyfpsye......g 300
                  + +ee  +++ ++c ++ +  + +p++++ nK+D+ ee++   k+g  ++k f + +       
  EFC38887.1  92 ASSFEEVKDIYGQLCRSRDVgeEGIPVCILGNKIDLEEERVisyKEGeGFAKQFAKCKffetsaY 156
                 466799999********99976689***********99999777666666666655554445442 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   3.2e-05     0.082       3      92 ..      12      97 ..      10     124 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 3.2e-05
                EEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSE.EEEEEEETTEEEEEEECGGCSSHHHHHH.HHHHHHHHHHCTSEEEEEEETT..TTCSHH CS
    MMR_HSR1  3 aivGrpNvGKStLinaltgekaivsdkpgtTrdi.negrvklkgkeielvDtpGliegaseek.glgkaflaleeadlillvvdas..eeklkp 92
                + +G   vGKS +  + ++++ + +  p       ++++v+ k  +i l+Dt+G  e    e   +++++ +  e d ++lv +++  + ++++
  EFC38887.1 12 VMLGSGGVGKSAVTIQFIKKEFKFGYDPTIEDAYtVQRTVDNKPVSISLLDTAG-QE----EFtAMRDQYMR--EGDGFILVYSITdaS-SFEE 97
                6789999*************99998888655555255556655599********.54....34478888886..456666666555221.2332 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.4    0.0033       8.4     101     116 ..      10      25 ..       2      35 .. 0.78
   2 ?    3.3   0.0     0.028        71      44      68 ..     113     138 ..     109     174 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0033
                  EEEEECSTTSSHHHHH CS
  RsgA_GTPase 101 tsvlvGqSGvGKStLi 116
                    v++G+ GvGKS++ 
   EFC38887.1  10 KFVMLGSGGVGKSAVT 25 
                  5699*********975 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.028
                  HTT-EEEEEEE-GGG--HHH.HHHHH CS
  RsgA_GTPase  44 ekgiepvivlnKiDlleeee.eleel 68 
                  e+gi++ i+ nKiDl ee+  +++e 
   EFC38887.1 113 EEGIPVCILGNKIDLEEERViSYKEG 138
                  6899***********99987533333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       470  (0.0262145); expected 358.6 (0.02)
Passed bias filter:                      386  (0.0215294); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1380.80
//
Query:       EFC38888.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.2e-16   57.8  10.3    2.9e-05   23.9   0.3    5.5  5  NHL           NHL repeat
    3.6e-06   26.6   1.0       0.15   12.0   0.2    3.1  3  PQQ           PQQ enzyme repeat
    3.4e-05   23.2   1.2     0.0095   15.1   0.1    2.6  2  DUF5128       6-bladed beta-propeller
     0.0001   22.0   0.1       0.27   10.8   0.0    2.6  3  SGL           SMP-30/Gluconolactonase/LRE-like region
     0.0011   19.4   0.1      0.076   13.5   0.1    2.7  2  PQQ_3         PQQ-like domain
     0.0048   17.1   0.0       0.14   12.4   0.0    2.6  2  Arylesterase  Arylesterase
  ------ inclusion threshold ------
      0.017   14.7   0.0      0.031   13.9   0.0    1.5  1  PQQ_2         PQQ-like domain
      0.025   13.9   0.0        1.9    7.6   0.0    2.9  2  Lactonase     Lactonase, 7-bladed beta-propeller


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0    0.0014       3.2      14      28 .]     101     115 ..      87     115 .. 0.82
   2 ?    1.2   0.1       0.2   4.4e+02      10      22 ..     138     151 ..     134     152 .. 0.83
   3 !    6.1   0.2    0.0055        12       6      23 ..     179     197 ..     175     202 .. 0.82
   4 !   23.9   0.3   1.3e-08   2.9e-05       1      28 []     267     295 ..     267     295 .. 0.97
   5 !   20.9   0.0   1.1e-07   0.00025       8      28 .]     323     344 ..     323     344 .. 0.95

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0014
                 EEEEEECCCTEEEEE CS
         NHL  14 diyVaDsenhrvqvF 28 
                  i+V+D++n rv vF
  EFC38888.1 101 LILVSDCGNRRVSVF 115
                 69************9 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.2
                 E.TTTEEEEEECCC CS
         NHL  10 d.snGdiyVaDsen 22 
                 d  +G i+ +D+++
  EFC38888.1 138 DgEDGLIIACDNGH 151
                 557999*****987 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0055
                 EEEEE.TTTEEEEEECCCT CS
         NHL   6 Gvavd.snGdiyVaDsenh 23 
                 +v v+   G++y+ D++  
  EFC38888.1 179 SVYVNrGRGHVYIGDFNDG 197
                 68899999*******9865 PP

  == domain 4  score: 23.9 bits;  conditional E-value: 1.3e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 fn P+G++vd +n +i+V+D +n  +++F
  EFC38888.1 267 FNGPRGICVDkTNQNIFVCDEGNDKIHIF 295
                 99*********************999998 PP

  == domain 5  score: 20.9 bits;  conditional E-value: 1.1e-07
                 EEE.TTTEEEEEECCCTEEEEE CS
         NHL   8 avd.snGdiyVaDsenhrvqvF 28 
                 a++ ++G+++VaD++n r+q+F
  EFC38888.1 323 AINyQSGELLVADTNNYRIQIF 344
                 68889****************9 PP

>> PQQ  PQQ enzyme repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       6.3   1.4e+04       7      19 ..     107     119 ..     103     119 .. 0.79
   2 !   11.9   0.0   7.7e-05      0.17       2      27 ..     142     167 ..     141     176 .. 0.90
   3 !   12.0   0.2   6.8e-05      0.15       1      20 [.     187     207 ..     187     211 .. 0.96

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 6.3
                 ETTSEEEEEETTT CS
         PQQ   7 sadGylyAlDadT 19 
                 + + ++  +D +T
  EFC38888.1 107 CGNRRVSVFDSYT 119
                 5678999999887 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 7.7e-05
                 EEEEEETTSEEEEEETTTCCEEEEEE CS
         PQQ   2 vvylgsadGylyAlDadTGkvlWrfk 27 
                 ++++++++G+++ +D++ Gk +W+++
  EFC38888.1 142 GLIIACDNGHVFMYDLELGKFRWKTR 167
                 67999******************987 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 6.8e-05
                 TEEEEE.ETTSEEEEEETTTC CS
         PQQ   1 gvvylg.sadGylyAlDadTG 20 
                 g+vy+g  +dG ++ lD++TG
  EFC38888.1 187 GHVYIGdFNDGGVRVLDIETG 207
                 79******************9 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.1    0.0024       5.4     100     148 ..      89     136 ..      84     183 .. 0.80
   2 !   15.1   0.1   4.3e-06    0.0095      58      92 ..     275     309 ..     247     310 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0024
     DUF5128 100 qindfiidksnesIyildfmknkiltYdLegykfieekkldllvsdvaq 148
                    d+ id++   I + d  ++++ ++d ++ +f+ +++l   ++ + q
  EFC38888.1  89 APMDIKIDEKRALILVSDCGNRRVSVFDSYTKEFKFNIQLNSHPCTI-Q 136
                 567999*********99**************9**9999999998755.2 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 4.3e-06
     DUF5128  58 ikvvdkrifvlDsaknnlfvFdkkGkfvrkIgaqG 92 
                 +  +++ ifv D+ + ++ +Fd +G+f+r  g+ G
  EFC38888.1 275 VDKTNQNIFVCDEGNDKIHIFDRSGNFIRSFGEYG 309
                 55678999999999999999999999999888776 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0   0.00071       1.6      10     111 ..      97     201 ..      93     225 .. 0.72
   2 !   10.8   0.0   0.00012      0.27     184     218 ..     269     303 ..     253     318 .. 0.88
   3 !    8.6   0.0   0.00055       1.2     188     218 ..     272     303 ..     272     343 .. 0.91

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00071
         SGL  10 eegaLlwv.Dilgqrihrldpatgketv.ldtpe.svGaiaprkdgrlvvasksglalldlasgeletladeeedekpllrfNDgvvdp.dGrlwfGtm 104
                 e++aL++v D  ++r+  +d+ t++ ++ +++++ + ++  + +dg ++++ +++++++dl+ g+++  ++ e ++ ++  +  + v + +G++++G+ 
  EFC38888.1  97 EKRALILVsDCGNRRVSVFDSYTKEFKFnIQLNShPCTIQLDGEDGLIIACDNGHVFMYDLELGKFRWKTRDEFHR-EDSYLGSVYVNRgRGHVYIGDF 194
                 44555544488888888888888888874444444445555566699999999999999*9999999999886566.6777777766543788999999 PP

         SGL 105 gdeeakg 111
                 +d+ ++ 
  EFC38888.1 195 NDGGVRV 201
                 9887765 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00012
         SGL 184 gepDGlavDa.eGnvwvAvwgggkvvrfdpdGklie 218
                 g p G++vD+ + n++v+  g++k++ fd  G+ i+
  EFC38888.1 269 G-PRGICVDKtNQNIFVCDEGNDKIHIFDRSGNFIR 303
                 3.88******99********************9887 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00055
         SGL 188 GlavDa.eGnvwvAvwgggkvvrfdpdGklie 218
                 G++vD+ + n++v+  g++k++ fd  G+ i+
  EFC38888.1 272 GICVDKtNQNIFVCDEGNDKIHIFDRSGNFIR 303
                 899**9999*****************999887 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.067   1.5e+02      22      39 ..     141     158 ..     128     158 .. 0.78
   2 !   13.5   0.1   3.4e-05     0.076       2      40 .]     161     206 ..     160     206 .. 0.68

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.067
       PQQ_3  22 glvyvgtgdGtlyAlDae 39 
                 + + +++++G+++++D e
  EFC38888.1 141 DGLIIACDNGHVFMYDLE 158
                 346677889****99975 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 3.4e-05
       PQQ_3   2 evlWsv.....qlpgpvnsspavd..gglvyvgtg.dGtlyAlDaet 40 
                 + +W++     +  + + +s+ v    g+vy+g+  dG+++ lD et
  EFC38888.1 161 KFRWKTrdefhRE-DSYLGSVYVNrgRGHVYIGDFnDGGVRVLDIET 206
                 5577776633222.234477755421589****************98 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.15   3.3e+02      52      80 ..      86     114 ..      81     120 .. 0.84
   2 !   12.4   0.0   6.1e-05      0.14      51      83 ..     265     297 ..     260     300 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.15
  Arylesterase  52 glssanGInidadkkyiyvadilresihv 80 
                   +++++  I+id ++  i v+d  ++ + v
    EFC38888.1  86 QFDAPMDIKIDEKRALILVSDCGNRRVSV 114
                   6999****************987776655 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 6.1e-05
  Arylesterase  51 sglssanGInidadkkyiyvadilresihvmkk 83 
                   s+++ + GI +d  ++ i+v d  +++ih++++
    EFC38888.1 265 SSFNGPRGICVDKTNQNIFVCDEGNDKIHIFDR 297
                   7999*************************9876 PP

>> PQQ_2  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   1.4e-05     0.031      43     193 ..     107     207 ..      77     252 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.4e-05
       PQQ_2  43 tgggrlvaldaatGkvlWettlegpvvgaplvaegrvvvvasdgqlialdaedGkrlWstqqrseepaelrssaspava.gdtvvvgessgklvaldpk 140
                  g +                                        +++ +d+ + + ++++q++s++++         ++  d +++++ +g + ++d++
  EFC38888.1 107 CGNR----------------------------------------RVSVFDSYTKEFKFNIQLNSHPCTI-------QLDgEDGLIIACDNGHVFMYDLE 158
                 2444........................................5555555555555555555544444.......33334555555555555555555 PP

       PQQ_2 141 dGkvlWerelaaprgtselsrvgdisgrpvvaeg..tVyassgqgrllal.dlatg 193
                  Gk +W++         e +r ++  g++ v++g   Vy+  ++ + + + d++tg
  EFC38888.1 159 LGKFRWKTRD-------EFHREDSYLGSVYVNRGrgHVYIGDFNDGGVRVlDIETG 207
                 5555555522.......233333444555555444455555555554555555555 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.052   1.2e+02      60     125 ..     149     214 ..     139     220 .. 0.77
   2 ?    7.6   0.0   0.00086       1.9     150     171 ..     275     296 ..     258     304 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.052
                 TTEEEEEEEETTTTEEEEEEEEE.SSS-EEEEEE-TTSSEEEEEETTTTEEEEEEB.TTSEBESEC CS
   Lactonase  60 eggvsafaidkdsgeltllnkvssegaspchlsvdedgkllavAnYsggsvsvfpldadgslkeas 125
                 +g+v  ++++  + +++  ++   e++    + v++++ ++++ +++ g v+v++++   ++k  s
  EFC38888.1 149 NGHVFMYDLELGKFRWKTRDEFHREDSYLGSVYVNRGRGHVYIGDFNDGGVRVLDIETGIDIKGDS 214
                 56666666666666667777777778888889999********************99876666655 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.00086
                 E-TTSSEEEEEETTTTEEEEEE CS
   Lactonase 150 ldpdgkfllvpDLGtDrvrvyk 171
                 +d++++ ++v+D G D++++++
  EFC38888.1 275 VDKTNQNIFVCDEGNDKIHIFD 296
                 5666677777777777777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       392  (0.021864); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.53
# Mc/sec: 1942.98
//
Query:       EFC38889.1  [L=215]
Description: phosphoglycerate mutase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.3e-42  143.7   0.0    6.5e-42  143.4   0.0    1.0  1  His_Phos_1  Histidine phosphatase superfamily (branch 1)


Domain annotation for each model (and alignments):
>> His_Phos_1  Histidine phosphatase superfamily (branch 1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.4   0.0   3.6e-46   6.5e-42       1     186 [.       6     197 ..       6     202 .. 0.91

  Alignments for each domain:
  == domain 1  score: 143.4 bits;  conditional E-value: 3.6e-46
                 EEEEE---BTTB--....TT----B-HHHHHHHHHHHHHHTT..S---EEEE-SSHHHHHHHHHHHHCTT...--EEE-GGGS----GGGTT-B.HHHH CS
  His_Phos_1   1 lyLvRHGetewnaegrlqgrtdvpLteeGreqAealaerlag..epidaiysSplkRarqTaeliaealg...lpveldegLrEidfGdweglttaeia 94 
                 +yL+RHG+t wn e++lqg++d+pL+e+G+ qA++l e +++   p++a+y+S++ Rar+T+e++++ +    +p+ ++e LrE  + +weg++++ei+
  EFC38889.1   6 VYLIRHGQTNWNLERKLQGHNDIPLNELGEMQAQELCETFRKvtKPFSAVYCSDMLRARKTVEIALKDTPhqhIPILETELLREKFMSHWEGKSFEEIR 104
                 69****************************************999**********************999999**********************9999 PP

                 HH..HSHHHHHHHHH-GGG-B....S-BHHHHHHHHHHHHH.HHHHHTTTSEEEEEE-HHHHHHHHHHHHT--GGGGGGB---TT-EEEEEE-SS-E CS
  His_Phos_1  95 eeypeeleawlrdpadvrppg....gEsledvaaRvaaale.elaarhegetvlvVsHggvirallarllglpleelrrleldnaslsvlefdeggw 186
                 e  ++++++w+++++ +   +     E+  +v+aR++++++ ++ +++ getvl  +H+gvi ++l +   l+ ++  +++++n+++ ++++ ++g 
  EFC38889.1 105 EIEEDFHHTWNSKDE-FLSFKcdpkAECHTEVYARLMNFVQnQVFHKNVGETVLFSTHAGVIGTILYH---LDFKAGYDWHVPNCTWIKVRISKEGN 197
                 996666666665555.555445778***************989999999******************9...78999999************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       510  (0.0284455); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1340.73
//
Query:       EFC38890.1  [L=359]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.4e-22   76.2  10.0    7.9e-05   22.4   0.0   11.2 12  LRR_6            Leucine Rich repeat
    3.4e-18   65.2  27.9    1.4e-05   24.8   2.9    6.2  7  LRR_8            Leucine rich repeat
    4.7e-14   52.3  35.0      0.005   17.2   2.5    8.4  9  LRR_4            Leucine Rich repeats (2 copies)
    7.3e-05   22.8  11.1        8.9    7.3   0.1    8.1 10  LRR_1            Leucine Rich Repeat
     0.0013   18.2   9.3       0.26   10.8   0.1    3.9  4  LRR_9            Leucine-rich repeat
     0.0038   17.3   2.3       0.56   10.4   0.2    3.3  3  TypeIII_RM_meth  Type III restriction/modification enzyme met
  ------ inclusion threshold ------
      0.085   13.2   0.0       0.54   10.6   0.0    2.4  3  DUF5347          Family of unknown function (DUF5347)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.15   3.9e+02       4      24 .]      63      83 ..      60      83 .. 0.86
   2 ?    1.2   0.0       0.2   5.2e+02      11      23 ..      95     107 ..      95     108 .. 0.84
   3 !    7.0   0.0    0.0027       6.8       5      24 .]     113     133 ..     109     133 .. 0.75
   4 ?    0.7   0.0      0.28   7.3e+02       3      18 ..     136     151 ..     134     157 .. 0.81
   5 !    8.0   0.0    0.0013       3.4       5      23 ..     162     180 ..     160     181 .. 0.91
   6 !   10.4   0.0   0.00022      0.56       5      23 ..     186     204 ..     185     205 .. 0.92
   7 ?   -1.8   0.0       1.7   4.4e+03      12      24 .]     217     229 ..     216     229 .. 0.83
   8 ?    3.9   0.0     0.027        69       3      23 ..     232     252 ..     230     252 .. 0.82
   9 !   11.8   0.1   7.9e-05       0.2       5      24 .]     258     277 ..     254     277 .. 0.89
  10 ?    0.7   0.1      0.28   7.2e+02       5      17 ..     282     294 ..     281     298 .. 0.86
  11 !   22.4   0.0   3.1e-08   7.9e-05       3      23 ..     304     324 ..     302     325 .. 0.89
  12 ?   -0.1   0.0       0.5   1.3e+03       8      16 ..     338     346 ..     337     347 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.15
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                +Lt++ Ls+  I+ +Ga+ La
  EFC38890.1 63 KLTKVYLSSETIDSKGAKYLA 83
                78999999999******9997 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.2
       LRR_6  11 sgNdIgDeGaeaL 23 
                 s+N++g+e +  L
  EFC38890.1  95 SYNNFGNESLYYL 107
                 89******98766 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0027
       LRR_6   5 LteLdL.sgNdIgDeGaeaLa 24 
                 Lt+L++ s N+I+ eG+e L+
  EFC38890.1 113 LTKLSIgSKNNITYEGVEYLS 133
                 55566636799******9885 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.28
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 ++Lt+L ++gN+ +De
  EFC38890.1 136 SKLTYLCITGNETTDE 151
                 79****9**9986665 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0013
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++L++ +N I+D+ ae +
  EFC38890.1 162 LKTLNIYSNLISDKSAEYI 180
                 9**************9987 PP

  == domain 6  score: 10.4 bits;  conditional E-value: 0.00022
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L ++ N+Ig +Ga+ +
  EFC38890.1 186 LTVLVINNNQIGSKGAKFI 204
                 89**************977 PP

  == domain 7  score: -1.8 bits;  conditional E-value: 1.7
       LRR_6  12 gNdIgDeGaeaLa 24 
                 + ++g  G++ ++
  EFC38890.1 217 YTKLGETGVKHIC 229
                 6788999***998 PP

  == domain 8  score: 3.9 bits;  conditional E-value: 0.027
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 t Lt+L +   +Ig++Ga+ +
  EFC38890.1 232 TQLTHLYICNTKIGNSGAKNI 252
                 568888888888******965 PP

  == domain 9  score: 11.8 bits;  conditional E-value: 7.9e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ Ld+s+N+I++e +e L+
  EFC38890.1 258 LQLLDISYNGINNEIVELLS 277
                 777*************9986 PP

  == domain 10  score: 0.7 bits;  conditional E-value: 0.28
       LRR_6   5 LteLdLsgNdIgD 17 
                 Lt L++sg  I++
  EFC38890.1 282 LTFLNISGSAIDN 294
                 899****998876 PP

  == domain 11  score: 22.4 bits;  conditional E-value: 3.1e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 + Lt+Ld+s+N+I+DeG++ +
  EFC38890.1 304 NQLTYLDVSYNGINDEGLIYI 324
                 579***************987 PP

  == domain 12  score: -0.1 bits;  conditional E-value: 0.5
       LRR_6   8 LdLsgNdIg 16 
                 L+Ls N++g
  EFC38890.1 338 LQLSRNQMG 346
                 89*****98 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0         2   5.2e+03      15      31 ..      29      45 ..      28      45 .. 0.76
   2 !   15.7   0.0   3.6e-06    0.0093      19      60 ..      56      98 ..      51      99 .. 0.92
   3 !    8.4   0.1   0.00069       1.8      22      59 ..     108     146 ..     105     148 .. 0.80
   4 !   24.5   1.0   6.7e-09   1.7e-05       2      55 ..     161     214 ..     160     220 .. 0.94
   5 !   24.8   2.9   5.4e-09   1.4e-05       2      60 ..     233     291 ..     232     292 .. 0.94
   6 !   14.0   0.6   1.2e-05     0.031       2      38 ..     281     317 ..     280     319 .. 0.88
   7 ?   -2.2   0.0       1.4   3.7e+03      30      37 ..     338     345 ..     337     352 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2
                EE-TTSSTT-TT--EEE CS
       LRR_8 15 slddeaFkglsnLkvLd 31
                +l+ ++ ++++nL+v+d
  EFC38890.1 29 KLKGQFLENVENLQVFD 45
                67788888999999865 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 3.6e-06
                TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S.S- CS
       LRR_8 19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg.Nr 60
                e F+++++L+  +Ls+ ++++  ++ ++gL++L+ +++++ N+
  EFC38890.1 56 EIFESMKKLTKVYLSSETIDSKGAKYLAGLNNLTDIHVDSyNN 98
                68**********************************9988665 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.00069
                 TT-TT--EEE-.-SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  22 kglsnLkvLdL.snNllttlspgafsgLpsLrsLdLsgN 59 
                 ++ls+L+ L++ s N++t    + +s+L++L++L ++gN
  EFC38890.1 108 SKLSQLTKLSIgSKNNITYEGVEYLSQLSKLTYLCITGN 146
                 568888888884457999988889999999999988888 PP

  == domain 4  score: 24.5 bits;  conditional E-value: 6.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 +L++L++ +N +++ + e  ++l  L+vL ++nN++ +  ++ +sg+++L++L 
  EFC38890.1 161 QLKTLNIYSNLISDKSAEYISNLDELTVLVINNNQIGSKGAKFISGMKQLKQLS 214
                 79*************************************************996 PP

  == domain 5  score: 24.8 bits;  conditional E-value: 5.4e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt L+++n+++ + + +   +l++L+ Ld+s+N ++    + +s+L +L++L++sg  
  EFC38890.1 233 QLTHLYICNTKIGNSGAKNIIKLKQLQLLDISYNGINNEIVELLSQLDQLTFLNISGSA 291
                 8***********************************99557***************965 PP

  == domain 6  score: 14.0 bits;  conditional E-value: 1.2e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 +Lt L++s + + +l  ++ +++++L++Ld s+N ++
  EFC38890.1 281 QLTFLNISGSAIDNLALTFINKMNQLTYLDVSYNGIN 317
                 6888999999999999999999999999999999775 PP

  == domain 7  score: -2.2 bits;  conditional E-value: 1.4
                 EE--SS-- CS
       LRR_8  30 LdLsnNll 37 
                 L+Ls+N++
  EFC38890.1 338 LQLSRNQM 345
                 56666665 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.026        66      17      33 ..      56      72 ..      26      78 .. 0.81
   2 ?    5.4   2.5      0.01        27      10      30 ..      96     118 ..      62     127 .. 0.48
   3 !   13.3   0.2   3.5e-05     0.089       2      33 ..     112     146 ..     111     152 .. 0.84
   4 !   14.8   1.0   1.1e-05     0.028       2      38 ..     137     174 ..     136     184 .. 0.86
   5 !   17.2   2.5   1.9e-06     0.005       1      37 [.     160     197 ..     160     199 .. 0.85
   6 !   12.2   0.1   7.3e-05      0.19       2      29 ..     185     214 ..     184     221 .. 0.84
   7 !   11.9   6.7   9.2e-05      0.24       2      34 ..     233     270 ..     232     298 .. 0.53
   8 !   13.9   0.8   2.2e-05     0.055       2      37 ..     281     317 ..     280     332 .. 0.84
   9 ?   -1.6   0.0       1.6   4.1e+03       5      15 ..     337     347 ..     333     348 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.026
                S-HHH-TT--EEE-.-S CS
       LRR_4 17 plleklpnLkeLdLsgN 33
                + +e++++L++++Ls+ 
  EFC38890.1 56 EIFESMKKLTKVYLSSE 72
                34778*********764 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.01
                 SS---E-S-..HHH-TT--EEE- CS
       LRR_4  10 nNqltdipl..leklpnLkeLdL 30 
                  N+    +l  l+kl +L++L++
  EFC38890.1  96 YNNFGNESLyyLSKLSQLTKLSI 118
                 23333222233335666666666 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 3.5e-05
                 S--EEE--.SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLs.nNqltdipl..leklpnLkeLdLsgN 33 
                 +L++L+++  N++t  +   l++l +L++L ++gN
  EFC38890.1 112 QLTKLSIGsKNNITYEGVeyLSQLSKLTYLCITGN 146
                 79******98****555578889*******99999 PP

  == domain 4  score: 14.8 bits;  conditional E-value: 1.1e-05
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 +L++L++ +N  td +  l + +++Lk+L++ +N li+d
  EFC38890.1 137 KLTYLCITGNETTDEQVkLISsFKQLKTLNIYSN-LISD 174
                 8************999995544*********666.8866 PP

  == domain 5  score: 17.2 bits;  conditional E-value: 1.9e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L++ +N ++d +   +++l+ L++L + +Nn+i+
  EFC38890.1 160 KQLKTLNIYSNLISDKSAeyISNLDELTVLVI-NNNQIG 197
                 58************977766557*******99.888996 PP

  == domain 6  score: 12.2 bits;  conditional E-value: 7.3e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLd 29 
                  L+vL ++nNq+ + +   ++++++Lk+L+
  EFC38890.1 185 ELTVLVINNNQIGSKGAkfISGMKQLKQLS 214
                 69***********866684446*****995 PP

  == domain 7  score: 11.9 bits;  conditional E-value: 9.2e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S...- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN...n 34 
                 +L++L++ n+++   +   + kl++L+ Ld+s N   n
  EFC38890.1 233 QLTHLYICNTKIGNSGAknIIKLKQLQLLDISYNginN 270
                 56666666666665444333356666666665552222 PP

  == domain 8  score: 13.9 bits;  conditional E-value: 2.2e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L++L++s+  +  + l  ++k+ +L++Ld+s N  i+
  EFC38890.1 281 QLTFLNISGSAIDNLALtfINKMNQLTYLDVSYN-GIN 317
                 69******88999999996667*********999.553 PP

  == domain 9  score: -1.6 bits;  conditional E-value: 1.6
                 EEE--SS---E CS
       LRR_4   5 vLdLsnNqltd 15 
                 +L Ls Nq+ +
  EFC38890.1 337 FLQLSRNQMGS 347
                 58999999876 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       4.3   1.1e+04       1      19 [.      63      81 ..      63      85 .. 0.70
   2 ?   -2.7   0.1       6.6   1.7e+04       7      12 ..      93      99 ..      86     111 .. 0.52
   3 ?   -2.8   0.0         7   1.8e+04       2      10 ..     113     122 ..     112     132 .. 0.69
   4 ?    1.0   0.0      0.41   1.1e+03       1      12 [.     137     148 ..     137     159 .. 0.75
   5 !    7.3   0.1    0.0035       8.9       1      23 []     161     183 ..     161     183 .. 0.93
   6 ?    2.2   0.0      0.16   4.1e+02       2      21 ..     186     205 ..     185     207 .. 0.81
   7 ?    1.9   0.0       0.2   5.1e+02       1      13 [.     233     245 ..     233     255 .. 0.76
   8 ?    4.0   0.3     0.042   1.1e+02       1      16 [.     257     272 ..     257     280 .. 0.74
   9 ?   -0.6   0.0       1.4   3.5e+03       2      10 ..     282     290 ..     281     299 .. 0.81
  10 ?    3.8   0.0     0.048   1.2e+02       1      13 [.     305     317 ..     305     329 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 4.3
       LRR_1  1 nLrhLdLsnnpllglppns 19
                +L++ +Ls+  ++++++ +
  EFC38890.1 63 KLTKVYLSSETIDSKGAKY 81
                7999999987776666655 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 6.6
       LRR_1  7 L.snnpl 12
                + s+n++
  EFC38890.1 93 VdSYNNF 99
                3444444 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 7
       LRR_1   2 LrhLdL.snn 10 
                 L++L + s n
  EFC38890.1 113 LTKLSIgSKN 122
                 8889884444 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.41
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L +++n  
  EFC38890.1 137 KLTYLCITGNET 148
                 79*******975 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.0035
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++L++ +n ++++++++++nL
  EFC38890.1 161 QLKTLNIYSNLISDKSAEYISNL 183
                 59**************9999987 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.16
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L++L ++nn+++++++  ++
  EFC38890.1 186 LTVLVINNNQIGSKGAKFIS 205
                 899*******9888776665 PP

  == domain 7  score: 1.9 bits;  conditional E-value: 0.2
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L+hL+++n  ++
  EFC38890.1 233 QLTHLYICNTKIG 245
                 59*****998775 PP

  == domain 8  score: 4.0 bits;  conditional E-value: 0.042
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L+ Ld+s+n + + +
  EFC38890.1 257 QLQLLDISYNGINNEI 272
                 599*******985544 PP

  == domain 9  score: -0.6 bits;  conditional E-value: 1.4
       LRR_1   2 LrhLdLsnn 10 
                 L+ L++s+ 
  EFC38890.1 282 LTFLNISGS 290
                 899***986 PP

  == domain 10  score: 3.8 bits;  conditional E-value: 0.048
       LRR_1   1 nLrhLdLsnnpll 13 
                 +L++Ld+s+n + 
  EFC38890.1 305 QLTYLDVSYNGIN 317
                 599*******983 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1     0.082   2.1e+02      58     119 ..      56     117 ..       9     133 .. 0.54
   2 !    5.4   0.1    0.0045        12      89     145 ..     112     165 ..     101     168 .. 0.67
   3 !   10.8   0.1    0.0001      0.26      61     119 ..     157     214 ..     148     223 .. 0.85
   4 !    6.2   1.0    0.0026       6.5      63     147 ..     231     311 ..     223     319 .. 0.67

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.082
       LRR_9  58 dgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklells 119
                 + f  +k+l  ++l+++ i   + +    l nl+ + + + +      l  l +l++l+ ls
  EFC38890.1  56 EIFESMKKLTKVYLSSETIDSKGAKYLAGLNNLTDIHVDSYNNFGNESLYYLSKLSQLTKLS 117
                 33555666666666666666665555555666666555443322333444455555555555 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0045
       LRR_9  89 nleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrll 145
                 +l++l + +++      ++ l +l+kl++l++  n  t+++     +i  +kql+ l
  EFC38890.1 112 QLTKLSIGSKNNITYEGVEYLSQLSKLTYLCITGNETTDEQ---VKLISSFKQLKTL 165
                 55555544333334556789999999999999999877654...4566666666655 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 0.0001
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklells 119
                   +k+lktl + +n i   + +    l +l+ lv++nn++ + +  + +  +k+l+ ls
  EFC38890.1 157 SSFKQLKTLNIYSNLISDKSAEYISNLDELTVLVINNNQIGSKGA-KFISGMKQLKQLS 214
                 45799************999999999**************99877.7777777777776 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0026
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldf 147
                 + +l  l++ n +i + +   ++ + +l++l l + + + +++ + +  l++l+ l++l+ + ++ ++  l  i+k++ql+ ld 
  EFC38890.1 231 MTQLTHLYICNTKIGNSG---AKNIIKLKQLQLLDISYNGINN-EIVELLSQLDQLTFLNISGSAIDNLALTFINKMNQLTYLDV 311
                 566777777776655444...4455555555555555555544.44445667777777777778888899999999999999884 PP

>> TypeIII_RM_meth  Type III restriction/modification enzyme methylation subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.2   0.00022      0.56      10      32 ..      26      48 ..      22      58 .. 0.87
   2 ?    4.8   0.0     0.012        31      31      49 ..     201     219 ..     191     222 .. 0.88
   3 ?   -1.3   0.1      0.93   2.4e+03      19      47 ..     284     313 ..     269     314 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00022
  TypeIII_RM_meth 10 kneeikehFfeevdgvlvFdkek 32
                     k+ ++k +F+e+v++  vFdk  
       EFC38890.1 26 KDTKLKGQFLENVENLQVFDKFR 48
                     6789****************965 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.012
  TypeIII_RM_meth  31 ekFaefienkeflpdSYTk 49 
                       kF+  +++ + l dSYTk
       EFC38890.1 201 AKFISGMKQLKQLSDSYTK 219
                      589999999999******8 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.93
  TypeIII_RM_meth  19 feevdgvlvFdke.kFaefienkeflpdSY 47 
                      f +++g ++ ++  +F++ +++  +l+ SY
       EFC38890.1 284 FLNISGSAIDNLAlTFINKMNQLTYLDVSY 313
                      555666665554337888888888998888 PP

>> DUF5347  Family of unknown function (DUF5347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00021      0.54       9      92 ..      82     165 ..      75     176 .. 0.85
   2 ?   -3.5   0.0       5.2   1.3e+04      80      92 ..     201     213 ..     194     217 .. 0.73
   3 ?   -2.5   0.0       2.4   6.2e+03      52      52 ..     317     317 ..     289     355 .. 0.51

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00021
     DUF5347   9 vdglnkvaklraklfkksdekeleeflkemRdkrdeky.kenkrvlsaifyLAeiekerhelkfeeltseekialikAlnklkav 92 
                 ++gln+++ ++ + +++  ++ l  +l+++ + +  ++ ++n+  ++ + yL +++k  + +   + t++e+++li+  ++lk +
  EFC38890.1  82 LAGLNNLTDIHVDSYNNFGNESL-YYLSKLSQLTKLSIgSKNNITYEGVEYLSQLSKLTYLCITGNETTDEQVKLISSFKQLKTL 165
                 689************95555555.677778777766653689999*************************************975 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 5.2
     DUF5347  80 ialikAlnklkav 92 
                 +++i+ +++lk +
  EFC38890.1 201 AKFISGMKQLKQL 213
                 5677788887765 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.4
     DUF5347  52 v 52 
                  
  EFC38890.1 317 N 317
                 2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (359 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       600  (0.0334653); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 2372.61
//
Query:       EFC38891.1  [L=322]
Description: sel1-like repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.7e-21   75.5   1.3    3.9e-07   30.5   0.0    5.4  5  Sel1         Sel1 repeat
     0.0045   17.0   0.2        1.6    9.1   0.0    3.2  2  TPR_2        Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.011   16.1   0.1       0.99    9.7   0.0    2.7  3  TPR_12       Tetratricopeptide repeat
      0.091   12.7   0.0        5.4    7.0   0.1    2.7  2  TPR_10       Tetratricopeptide repeat
       0.11   13.4   0.0         16    6.6   0.1    2.7  2  TPR_14       Tetratricopeptide repeat
       0.12   12.2   0.0         19    5.3   0.0    2.9  2  TPR_1        Tetratricopeptide repeat
        1.9    7.7   9.1        3.3    7.0   9.1    1.4  1  NOA36        NOA36 protein


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0     0.023        59      23      38 .]     111     126 ..      97     126 .. 0.79
   2 !   12.5   0.0   7.1e-05      0.18      23      37 ..     143     157 ..     132     158 .. 0.82
   3 !   30.5   0.0   1.5e-10   3.9e-07       3      38 .]     161     194 ..     160     194 .. 0.94
   4 !    7.2   0.0    0.0032       8.3       3      38 .]     197     229 ..     195     229 .. 0.78
   5 !   15.2   0.0   1.1e-05     0.027       2      37 ..     231     263 ..     230     264 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.023
        Sel1  23 pekAiewyekAAeqGd 38 
                 +++++ +  kAAe+G+
  EFC38891.1 111 KSQGFDFHLKAAELGH 126
                 7899999********9 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 7.1e-05
        Sel1  23 pekAiewyekAAeqG 37 
                  ++A++w++k+A++G
  EFC38891.1 143 HKEAFRWFKKSAKHG 157
                 578**********99 PP

  == domain 3  score: 30.5 bits;  conditional E-value: 1.5e-10
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 ++y+ G fy   nG g++k+++kA++w  ++A+qG+
  EFC38891.1 161 SQYKIGSFY--ANGVGTEKNIRKAFKWTTRSAQQGY 194
                 8*****777..***********************96 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.0032
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 A+ +L+ +  ++ G     D+ek + w+ekA +qGd
  EFC38891.1 197 AQINLAVLFHFEPG---YEDKEKNRFWLEKAVNQGD 229
                 88888855555555...56999999*********97 PP

  == domain 5  score: 15.2 bits;  conditional E-value: 1.1e-05
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                  Am++LG   +y n++ +  D e+A+e++ +A e+G
  EFC38891.1 231 GAMNDLG--KFYTNRD-EYEDLERALELFTRAEELG 263
                 59*****..666***7.888************9988 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0   0.00061       1.6       4      29 ..     130     155 ..     128     156 .. 0.92
   2 ?    4.0   0.4     0.026        66      16      30 ..     248     262 ..     231     263 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00061
       TPR_2   4 lynlGlayyklgdyeeAleafekAle 29 
                 ++ +G++ +k+++++eA ++f+k+ +
  EFC38891.1 130 HHTIGRVFEKRKEHKEAFRWFKKSAK 155
                 899********************876 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.026
       TPR_2  16 dyeeAleafekAlel 30 
                 d+e+Ale+f +A el
  EFC38891.1 248 DLERALELFTRAEEL 262
                 789999999999776 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0   0.00039      0.99      47      71 ..     129     153 ..     121     156 .. 0.86
   2 ?   -2.7   0.0         3   7.7e+03      43      55 ..     193     205 ..     177     208 .. 0.72
   3 ?    3.1   0.1     0.044   1.1e+02      57      74 ..     245     262 ..     232     265 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00039
      TPR_12  47 tlrnLgrlyralgryeeAlelleea 71 
                 + +++gr+++++++++eA ++++++
  EFC38891.1 129 SHHTIGRVFEKRKEHKEAFRWFKKS 153
                 7899999999999999999999998 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3
      TPR_12  43 ltattlrnLgrly 55 
                 +++++++nL+ l+
  EFC38891.1 193 GYVRAQINLAVLF 205
                 5678888888876 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.044
      TPR_12  57 algryeeAlelleealai 74 
                 + +++e Alel+++a ++
  EFC38891.1 245 EYEDLERALELFTRAEEL 262
                 457888888888888775 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.052   1.3e+02       8      28 ..     133     153 ..     131     155 .. 0.83
   2 ?    7.0   0.1    0.0021       5.4       4      20 ..     232     248 ..     231     259 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.052
      TPR_10   8 LanalrqrgrydeAealleea 28 
                 ++++  +r++++eA ++++++
  EFC38891.1 133 IGRVFEKRKEHKEAFRWFKKS 153
                 67778899*********9986 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0021
      TPR_10   4 slnNLanalrqrgryde 20 
                 ++n+L+  +++r +y++
  EFC38891.1 232 AMNDLGKFYTNRDEYED 248
                 8*************997 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0      0.05   1.3e+02       7      29 ..     133     155 ..     129     157 .. 0.86
   2 ?    6.6   0.1    0.0064        16       6      33 ..     235     265 ..     230     279 .. 0.66

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.05
      TPR_14   7 laeallalGdpdeAiallrrala 29 
                 ++++++ + +++eA + +++  +
  EFC38891.1 133 IGRVFEKRKEHKEAFRWFKKSAK 155
                 689***************98755 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0064
      TPR_14   6 alaeallalGd...pdeAiallrralalaPd 33 
                 +l++++ ++++   +++A++l+ ra +l+ +
  EFC38891.1 235 DLGKFYTNRDEyedLERALELFTRAEELGLK 265
                 7899999887622266688888888776654 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0    0.0075        19       6      27 ..     132     153 ..     128     156 .. 0.87
   2 ?    3.5   0.2     0.026        68      15      29 ..     247     261 ..     232     262 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0075
                 HHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyyekA 27 
                  +G ++ k ++++eA   ++k 
  EFC38891.1 132 TIGRVFEKRKEHKEAFRWFKKS 153
                 6899***************996 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.026
                 T-HHHHHHHHHHHHH CS
       TPR_1  15 gkydeAleyyekALe 29 
                 ++++ Ale + +A e
  EFC38891.1 247 EDLERALELFTRAEE 261
                 578888888888866 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   9.1    0.0013       3.3     270     301 ..     287     318 ..     255     322 .] 0.75

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0013
       NOA36 270 ddegdedddddddeedddeeeddedeeeeeee 301
                 d+++deddddd+de d++ e+dde  e+ e++
  EFC38891.1 287 DEYEDEDDDDDEDEVDENVEDDDEYFEDVEDD 318
                 55667777777777777777777766655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       891  (0.049696); expected 358.6 (0.02)
Passed bias filter:                      578  (0.0322383); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.50u 0.25s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 2236.78
//
Query:       EFC38892.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-36  124.5   0.0    5.2e-36  123.4   0.0    1.6  1  TrmO           tRNA-methyltransferase O
    8.8e-06   25.7   1.0    2.4e-05   24.3   0.0    2.2  2  TrmO_C         TrmO C-terminal domain
  ------ inclusion threshold ------
      0.063   13.4   3.6        8.4    6.5   0.1    2.9  3  DehI           Halocarboxylic acid dehydrogenase DehI
       0.13   12.1   0.1       0.33   10.9   0.1    1.6  1  NCBP3          Nuclear cap-binding protein subunit 3
       0.35   11.1   3.1       0.45   10.7   0.7    2.4  2  DDE_Tnp_IS240  DDE domain
        3.4    7.3  17.8        8.3    6.1  17.8    1.7  1  Cwf_Cwc_15     Cwf15/Cwc15 cell cycle control protein


Domain annotation for each model (and alignments):
>> TrmO  tRNA-methyltransferase O
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  123.4   0.0   1.8e-39   5.2e-36       1     119 []     279     407 ..     279     407 .. 0.94

  Alignments for each domain:
  == domain 1  score: 123.4 bits;  conditional E-value: 1.8e-39
                 TS-SSGGG--.-EEEEEE-HHH..HGGGTTGGG-SEEEEEEE-TTS.............-.SS--E-TT-.SS-E.EGGGS--S-SSS-EEEEEEEEEE CS
        TrmO   1 giPrqpglaeeaeaeielepeynseealegleefshlwllfvfhen..........aekklkakvrpprlggnervGvfatRsphRpnpiglsvvklek 89 
                 g+Prqp ++++ +a ++l p++n++++++gl e+sh++++f+f+ n          +++++kak+rpprlg n+++G++a+R+phR n+igls+v++++
  EFC38892.1 279 GCPRQPYYVNKGRAILKLLPHCNPSSSMDGLGEYSHCYIIFQFNLNtnltkgaetdSQNAIKAKIRPPRLG-NKKIGIYASRTPHRYNAIGLSIVEIDR 376
                 79******************************************77689888877655568*********7.699************************ PP

                 EE.TTEEEEES----TT-EEEEEEE--HHHH CS
        TrmO  90 ve.gnvlevsgvDlldgtpvlDiKPYvpyaD 119
                 ++ + +l+++g+Dl+dgt vlDiKPY+  +D
  EFC38892.1 377 IDsDGTLHLKGTDLVDGTAVLDIKPYIDGYD 407
                 **66***********************9888 PP

>> TrmO_C  TrmO C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.2      0.83   2.5e+03      16      32 ..      43      58 ..      23      64 .. 0.56
   2 !   24.3   0.0     8e-09   2.4e-05       2      57 ..     427     493 ..     426     501 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.83
      TrmO_C 16 qqlqksapdlkqlIeev 32
                +++qk +++l++ ++++
  EFC38892.1 43 RHQQKLEEQLRE-LNQT 58
                233344444443.2333 PP

  == domain 2  score: 24.3 bits;  conditional E-value: 8e-09
      TrmO_C   2 kleVeFseeaeaqlqql.........qksapdlkqlIeevLaqDPRPaYkkskpe..eriYgmrLyd 57 
                 k++VeFse a++ql++          +k+ +++ +++++vL+qD R  Ykk+k++  e ++ +   +
  EFC38892.1 427 KFKVEFSELATTQLKERihtleffdkKKELDEFIEFLTQVLSQDIRSNYKKTKNNeiEDEHELLVDR 493
                 789************9999999998777789********************9887333555555555 PP

>> DehI  Halocarboxylic acid dehydrogenase DehI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1      0.45   1.4e+03      33     104 ..      24      98 ..      20     125 .. 0.59
   2 ?    6.3   0.1    0.0032       9.6     109     143 ..     179     213 ..     166     216 .. 0.87
   3 ?    6.5   0.1    0.0028       8.4      16      80 ..     432     499 ..     430     504 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.45
        DehI  33 FeaaAaalreevlsdveeerkvasia..lreqevspaevaeleaelstF..desaPrLallaqalerslsgepvgt 104
                 F a A +  +  l  v++ r+ +++   lre++ +  ++++l a +s F  + s   +  l+ a + +l g  +g+
  EFC38892.1  24 FTATALSCMAAYLGYVQRMRHQQKLEeqLRELNQTISQEQQLHADISNFgkKTSDVSMIALFMA-SSALLGYSIGR 98 
                 6666666666666666666666666666777777777777777777777556666666544443.33344444455 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0032
        DehI 109 gssespdfesseeasaelprvldeikaslptlsvv 143
                 +  espd ++ +e s +l r++++ik +l++  ++
  EFC38892.1 179 DKEESPDSNNNNEKSSPLSREYMKIKIQLEKETTN 213
                 667999*********************99987766 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0028
        DehI  16 flrlawqqlkpaletkeFeaaAaalreev..lsdveeerkvasia.lreqevspaevaeleaelstFd 80 
                 f +la  qlk+ + t eF++  + l e++  l++v ++  +  ++  ++ e++ +++  +  + +tF 
  EFC38892.1 432 FSELATTQLKERIHTLEFFDKKKELDEFIefLTQVLSQDIRSNYKkTKNNEIEDEHELLVDRVKVTFT 499
                 5567889********************87557888766555555536777888888888888888885 PP

>> NCBP3  Nuclear cap-binding protein subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   0.00011      0.33       5      41 ..     382     421 ..     379     428 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00011
       NCBP3   5 alhirG...vdnLstedikaYvdeylnyeepfriEWIdDt 41 
                 +lh++G   vd     dik Y+d y n  + +  EWI D 
  EFC38892.1 382 TLHLKGtdlVDGTAVLDIKPYIDGYDNFANVKVPEWIKDP 421
                 6899996666777778***********9888888***995 PP

>> DDE_Tnp_IS240  DDE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       1.2   3.5e+03      74     112 ..      39      61 ..      11      83 .. 0.61
   2 ?   10.7   0.7   0.00015      0.45      79     125 ..     465     509 ..     430     513 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.2
  DDE_Tnp_IS240  74 lkelkregelfdevshvqvkylnnriEsdhrtlKkrlrp 112
                    ++++ +                ++ +E++ r+l + + +
     EFC38892.1  39 VQRMRH----------------QQKLEEQLRELNQTISQ 61 
                    333333................34444444433333333 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00015
  DDE_Tnp_IS240  79 regelfdevshvqvkylnnriEsdhrtlKkrlrptrgfkslksaakt 125
                    +   l ++++   +k +nn iE +h+ l +r+++t  ++s+++++k 
     EFC38892.1 465 Q--VLSQDIRSNYKKTKNNEIEDEHELLVDRVKVTFTIDSINKIHKI 509
                    2..35589999999**************************9998775 PP

>> Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1  17.8    0.0028       8.3     109     193 ..     154     240 ..      41     256 .. 0.69

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0028
                 .-----------------.........------------------------------------------------.-----------------.. CS
  Cwf_Cwc_15 109 reidaddedseeeeeeee.........eesdddsdsdsdddddedetaeLlrELekikreraeekerkerekaee.eekereeeiatgNpLlnlk 193
                 ++ d+ d+d+       +         +++++d++++ d++++++    L rE+ kik + ++e++ ++ e++ + +++++ +ei ++  L+n +
  EFC38892.1 154 NKSDKSDDDE-------TsffdrfkkeSRDENDKEESPDSNNNNEKSSPLSREYMKIKIQLEKETTNRQMERTGRvRAEQKIREI-EQKLLINST 240
                 1222222222.......12445555324444455555566666777788*********998877766666665540555555555.455667744 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2243  (0.125105); expected 358.6 (0.02)
Passed bias filter:                      740  (0.0412739); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.77u 0.37s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 2945.62
//
Query:       EFC38893.1  [L=502]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 2958.64
//
Query:       EFC38894.1  [L=521]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.2e-50  171.7  10.0    1.7e-46  158.9   0.9    3.1  3  PP2C       Protein phosphatase 2C
      9e-05   22.2   0.0    0.00033   20.4   0.0    2.0  1  PP2C_2     Protein phosphatase 2C
  ------ inclusion threshold ------
       0.15   11.5   1.2       0.17   11.3   0.0    1.6  2  QueC       Queuosine biosynthesis protein QueC
       0.47    9.7   8.6       0.49    9.6   6.7    1.9  2  SMN        Survival motor neuron protein (SMN)
        2.3    9.0   9.5       0.37   11.5   4.5    2.2  2  DTHCT      DTHCT (NUC029) region


Domain annotation for each model (and alignments):
>> PP2C  Protein phosphatase 2C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   2.0      0.47   1.7e+03      33      70 ..      18      55 ..       2      79 .. 0.42
   2 !   18.8   0.1   2.8e-07     0.001       5      82 ..     214     313 ..     211     330 .. 0.73
   3 !  158.9   0.9   4.9e-50   1.7e-46      50     257 ..     310     510 ..     291     511 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.47
                CCEEEEEEEEESSSHHHHHHHHHHHHHHHHHHHCHTTH CS
        PP2C 33 svsffavfdghggseaakyarehleeilksqksfeele 70
                ++  f  +++h  +  + + +e++++  +s++s ++++
  EFC38894.1 18 AETSFHQQQQHQQRNESLLSSENNNNENSSSSSSTTST 55
                33333333333333333333333332222222222221 PP

  == domain 2  score: 18.8 bits;  conditional E-value: 2.8e-07
                 EEEECCCCSSHHEEEECCCCTCTT...CCCCCCEEEEEEEEESSSHHHHHHHHHHH.HHHHHHHHCHTTH..................HHHHHHHHHHH CS
        PP2C   5 aselqgarksmedahislanless...sgkssvsffavfdghggseaakyarehle.eilksqksfeele..................kleqalrksfl 81 
                  +e+qg r smeda+ ++ +++s     g  ++  ++ fdghggs+a+k a+e l+  +l++  + e l                    l + lrk f+
  EFC38894.1 214 YCEFQGTRPSMEDALYCNMSFRSFtsdMGVLNETCIGLFDGHGGSKASKQASEILHsVFLDKLTKYENLLtryfedynsralireeakSLTKLLRKHFM 312
                 689******************999877778899***********************6344443333333345566665666776666666667777777 PP

                 H CS
        PP2C  82 a 82 
                 +
  EFC38894.1 313 E 313
                 6 PP

  == domain 3  score: 158.9 bits;  conditional E-value: 4.9e-50
                 HHHHHHHHHHHHHHHHCHTTH........HHHHHHHHHHHHHHHHHHHHHHHHCHCCT-EEEEEEEEEETTE...EEEEEESS-EEEEEETTEEEEECS CS
        PP2C  50 kyarehleeilksqksfeele........kleqalrksfladtdeelksskantepsksGstavvalirgtk...lyvAnvGDSravLcrkgnakkelt 137
                 ++++++ e++l++ +  e+++          + ++r+sfl+ +de +    +n   s  Gsta+++++   +   l+v+nvGDSr+vLcr+g+++ +lt
  EFC38894.1 310 HFMEKEAEQKLSEERAVEQFDilrmssvdAIQIIIRESFLE-ADELVCE--QN---SVDGSTATLVYMPTRDskfLFVGNVGDSRVVLCRDGKPI-TLT 401
                 55666666666666666666677777776688899******.8888877..44...789********9777777*********************.*** PP

                 ---STTSHHHHHHHHHTT--EEECCEEETTTBSBSB-EE-GGGTCCCCCCSTSB---EEEEEEE-TTEEEEEEE-HHHHTTSHHHHHHHHHHHHHHHHT CS
        PP2C 138 edHkpsdedEreRIeeaggsvsngegrvngsLavsRalGDlelkpketeeqlvsaePdvtsvklteedefliLacdGlwdvlsdqeavdlvrdelekkk 236
                 +dH+psd+dEr+R+++ag s++  ++r+   LavsR++GD+ + p       v+++P+++ + l e+def+i+acdG++d +s++eav  +rde +   
  EFC38894.1 402 VDHRPSDSDERRRVRDAGKSII--NNRISACLAVSRSIGDKTFHP------GVISDPHTQAIRLCEKDEFMIIACDGVFDFVSEEEAVREIRDETN--- 489
                 **********************..********************9......9********************************************... PP

                 HHHHHHHHHHHHHHHC.CHHCH CS
        PP2C 237 speevaeelvdeaiar.gsedn 257
                  p +++++l+d+a ++ gs dn
  EFC38894.1 490 -PITASTKLRDYAFNKkGSNDN 510
                 .9***********875166666 PP

>> PP2C_2  Protein phosphatase 2C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.0   9.2e-08   0.00033      29     188 ..     251     484 ..     236     500 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 9.2e-08
      PP2C_2  29 VaDGaGSakrSerGariaveavvealaell...eseeee..eeallraleaailadv.........................................l 81 
                   DG+G  k S+++++i+  ++  +l ++    ++  e+  ++al+r+  +++ + +                                         l
  EFC38894.1 251 LFDGHGGSKASKQASEILHSVFLDKLTKYEnllTRYFEDynSRALIREEAKSLTKLLrkhfmekeaeqklseeraveqfdilrmssvdaiqiiiresfL 349
                 579*****************99777766663333333335544444433322222223445777778888888899999**************999888 PP

      PP2C_2  82 keeaeaqdaelkdyatTllaav..vtpdeivalqiGDGaivvrdrdgevqllgepdsgeyanqttfltsedaeeel....................... 155
                 ++ +  ++++  d +t+ l+ +  ++ ++++++++GD+ +v+  rdg+   l+ ++    + + + +++   ++++                       
  EFC38894.1 350 EADELVCEQNSVDGSTATLVYMptRDSKFLFVGNVGDSRVVL-CRDGKPITLTVDHRPSDSDERRRVRDA--GKSIinnrisaclavsrsigdktfhpg 445
                 8888888888888888888888655567799*********65.688888887776554444443333332..222222224555566666666666666 PP

      PP2C_2 156 .......rirrlkledgdalllmTDGlanslrdeerfael 188
                        ++ rl  e+ +  +++ DG+ + +++ee+++e+
  EFC38894.1 446 visdphtQAIRLC-EKDEFMIIACDGVFDFVSEEEAVREI 484
                 6666655444444.34556666666666555555555555 PP

>> QueC  Queuosine biosynthesis protein QueC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.3       1.6   5.8e+03      29      80 ..      20      69 ..      10      78 .. 0.51
   2 ?   11.3   0.0   4.8e-05      0.17      35     104 ..     308     381 ..     302     386 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.6
                EEEESS-TTSHHHHHHHHHHHHT--.-EEEEE-GGGGGGSCGGG-------- CS
        QueC 29 ltfdYgqrhkkeleaakkiakelgveehkildldllkelggsaLtdeeievp 80
                 +f+ +q+h++ +e+   +++e + +e+   + ++ ++  +++ +++e++++
  EFC38894.1 20 TSFHQQQQHQQRNES--LLSSENNNNENSSSSSSTTSTAEQTSTMNSENKIN 69
                455555555544443..33444444444444444455555555555555555 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 4.8e-05
                 -TTSHHHHHHHHHHHHT--.-EEEEE-GGGGGGS....CGGG-----------...--------TTHHHHHHHH CS
        QueC  35 qrhkkeleaakkiakelgveehkildldllkelg....gsaLtdeeievpkeeleeeelpntfVpaRNliflsl 104
                 ++h +e ea +k+++e  ve+  il ++ + +++    +s L ++e   ++++++ +++  +++p+R   fl +
  EFC38894.1 308 RKHFMEKEAEQKLSEERAVEQFDILRMSSVDAIQiiirESFLEADELVCEQNSVDGSTATLVYMPTRDSKFLFV 381
                 46999********************99998887666645556666666677889999***********999866 PP

>> SMN  Survival motor neuron protein (SMN)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   6.7   0.00014      0.49     125     200 ..      30     103 ..       6     131 .. 0.57
   2 ?   -1.3   0.0      0.29     1e+03      33      71 ..     172     211 ..     163     269 .. 0.60

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00014
         SMN 125 ededalkeanvnetesstdesdrssrsakakdksnleiakssqknlrfppvppptppglgrrgekldtlgpflsgw 200
                 + +++l +++ n++e+s+  s  +s + ++    n e    s   +    +ppp     gr g  l+ + pfls+ 
  EFC38894.1  30 QRNESLLSSENNNNENSSSSSSTTSTAEQTST-MNSENKINS-SSSAATQGPPPSRGRGGRSGTILRGTAPFLSTT 103
                 11222222233333333333332222222222.222222222.3345567889999999**************975 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.29
         SMN  33 dcaepaekeekrpgkkrknnkkn.rsrkkcnaaplkkwkv 71 
                 d a  + ++e++ ++kr n +   r   ++  + + +w  
  EFC38894.1 172 DEALFKLAQERNRNRKRGNPRTAqRHDSQASKIEENDWLT 211
                 5555555566666666666544302223333344455555 PP

>> DTHCT  DTHCT (NUC029) region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   4.5    0.0001      0.37      13      97 ..       6      89 ..       2      91 .. 0.81
   2 ?   -2.0   0.2       1.7   5.9e+03      16      49 ..     171     199 ..     158     207 .. 0.47

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.0001
       DTHCT 13 sssDsdsdagakkkaaaaKgrkarKRktssssedddsdpgkktskatakKkkKkaseddddfsvdldseedseseaasRerpgRa 97
                ++ Ds+s++g+  +++  ++++ ++R++s  s++++ + ++  s +t++  + ++ ++++ +++++ s++  + +++sR r gR+
  EFC38894.1  6 TNIDSESSKGEIAETSFHQQQQHQQRNESLLSSENNNNENSSSSSSTTSTAEQTSTMNSE-NKINSSSSAATQGPPPSRGRGGRS 89
                578*******99999999999899999988777777777777777666666666566666.699999999999**********95 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.7
       DTHCT  16 DsdsdagakkkaaaaKgrkarKRktsssseddds 49 
                 D+++ ++ ++    +++r  rKR    + +  ds
  EFC38894.1 171 DDEALFKLAQ----ERNR-NRKRGNPRTAQRHDS 199
                 4444443333....3333.334333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (521 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2242  (0.125049); expected 358.6 (0.02)
Passed bias filter:                      777  (0.0433376); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.90u 0.41s 00:00:01.31 Elapsed: 00:00:00.58
# Mc/sec: 2718.80
//
Query:       EFC38895.1  [L=674]
Description: hypothetical protein NAEGRDRAFT_59412 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.4e-22   79.1   0.3    5.4e-22   77.9   0.3    1.6  1  UQ_con      Ubiquitin-conjugating enzyme
    6.9e-09   35.5   0.1    1.3e-08   34.5   0.1    1.5  1  F-box-like  F-box-like
    9.4e-07   28.6   0.1      3e-06   27.0   0.1    1.9  1  F-box       F-box domain
     0.0019   18.5   0.1     0.0076   16.5   0.1    2.1  1  RWD         RWD domain
  ------ inclusion threshold ------
      0.058   13.3   0.1       0.93    9.4   0.0    2.4  2  F-box_4     F-box


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.9   0.3   1.5e-25   5.4e-22       1     113 [.      22     139 ..      22     158 .. 0.92

  Alignments for each domain:
  == domain 1  score: 77.9 bits;  conditional E-value: 1.5e-25
                 HHHHHHHHHHHSTTTTEEEEEEETTEECEEEEEEEB.TTSTTTTEEEEEEEE--TTTTTS--EEEESST-SCTTBETTSBB-CGGGSTTT.......-- CS
      UQ_con   1 rlqkelkelakkkpsgisaklvddenlfewkvlikgpedtpYeggvFklelefpedYPlkpPkvkfvtkifHPnvdksGevcldiLkeek.......Ws 92 
                 rl k++ e+++++ + ++a++ ++ nlf+w +++  p+ + Y g +  le++fp+dYP++pP+vk+ t+++H +v+++  +cld+L++++       Ws
  EFC38895.1  22 RLSKDFIEIQNNPLDTVYAEPFEN-NLFHWYATLLAPQSSKYYGIIISLEITFPNDYPHSPPTVKCLTPLYHSHVYRQ-FICLDMLETHHseepymgWS 118
                 7899999****************7.***************************************************88.7*******88899999**** PP

                 TTSHHHHHHHHHHHHHHS--T CS
      UQ_con  93 paltlesvllsiqsLlaepnp 113
                 ++++  s+ll++q++l e + 
  EFC38895.1 119 SSYSCLSILLQLQAFLLEEEH 139
                 **************9966544 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   0.1   3.7e-12   1.3e-08       4      38 ..     234     267 ..     231     274 .. 0.88

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 3.7e-12
  F-box-like   4 LPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldt 38 
                  P+EiL++IFsyL++ dL r+  VC+ ++ ++ d+
  EFC38895.1 234 FPNEILIHIFSYLSFIDLKRVETVCKAFQHAC-DC 267
                 5****************************998.55 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.1   8.3e-10     3e-06       2      38 ..     230     266 ..     229     274 .. 0.93

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 8.3e-10
                 HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHT CS
       F-box   2 tlsrLPsevlrhILerLplsdllalrrVSkgwrilid 38 
                 ++ + P+e+l hI+++L+++dl +   V+k +  ++d
  EFC38895.1 230 SFEDFPNEILIHIFSYLSFIDLKRVETVCKAFQHACD 266
                 6899*******************************99 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.1   2.1e-06    0.0076      47      78 ..      59      90 ..       3     138 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 2.1e-06
                ..TT-CEEEEEEEEE-SSTTSS--EEEEEECC CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         RWD 47 feekkkpslkleiklpeeYPeeaPiislsste 78
                 ++ +   ++lei++p++YP+++P ++  ++ 
  EFC38895.1 59 SSKYYGIIISLEITFPNDYPHSPPTVKCLTPL 90
                45678899****************99876665 PP

>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   0.00026      0.93       4      40 ..     230     266 ..     227     290 .. 0.85
   2 ?    0.9   0.0      0.11     4e+02      66     101 ..     577     612 ..     568     623 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00026
     F-box_4   4 sLssLPlevlqhiaslLDsfsLsqLslvskllrevcs 40 
                 s++++P e+l hi s+L  + L ++  v+k +++ c 
  EFC38895.1 230 SFEDFPNEILIHIFSYLSFIDLKRVETVCKAFQHACD 266
                 67899***************************99985 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.11
     F-box_4  66 kikkkvwefstlfskv.ksWkfedvsslseHLkkCpf 101
                 ki+ kv +f + f+ v  + +f++ +++++ L++C  
  EFC38895.1 577 KIQ-KVSSFEEYFEYVgFNNEFSSATTIAQYLRNCVK 612
                 554.488999999999557899999**********74 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (674 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1235  (0.0688828); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.69u 0.36s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 3994.18
//
Query:       EFC38896.1  [L=1059]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.4e-11   43.3  24.8        0.1   12.6   0.1    9.7 10  EF-hand_6       EF-hand domain
      2e-09   37.5   0.1    6.7e-09   35.8   0.0    2.0  2  PRK             Phosphoribulokinase / Uridine kinase family
    1.3e-08   35.7  27.9      0.034   15.0   0.1    8.2  8  EF-hand_11      EF-hand domain
    0.00053   20.5   0.0     0.0053   17.3   0.0    2.8  2  AAA_18          AAA domain
     0.0011   19.4   0.8     0.0011   19.4   0.8    8.8 10  EF-hand_7       EF-hand domain pair
     0.0024   17.7   0.1     0.0091   15.8   0.0    2.1  2  ATP_bind_1      Conserved hypothetical ATP binding protein
     0.0032   16.9  22.7        1.7    8.4   0.1    8.3  8  EF-hand_1       EF hand
     0.0036   17.6   0.0      0.082   13.2   0.0    2.9  2  AAA_22          AAA domain
     0.0078   16.6   0.1       0.12   12.8   0.0    2.9  4  AAA_16          AAA ATPase domain
  ------ inclusion threshold ------
      0.016   15.8   2.6         18    6.0   0.0    5.1  5  FGAR-AT_linker  Formylglycinamide ribonucleotide amidotransfe
      0.022   14.7  11.4        2.8    7.9   0.2    6.8  9  RST             RCD1-SRO-TAF4 (RST) plant domain
        5.7    7.2   6.5        8.6    6.6   0.1    4.0  3  DUF5446         Family of unknown function (DUF5446)


Domain annotation for each model (and alignments):
>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.1   6.8e-05       0.1       1      31 []     178     207 ..     178     207 .. 0.92
   2 ?    4.1   0.0     0.035        52       3      26 ..     290     313 ..     289     315 .. 0.90
   3 !   11.2   0.2   0.00019      0.28       2      26 ..     389     413 ..     388     417 .. 0.89
   4 ?    2.6   0.1      0.11   1.6e+02       5      26 ..     515     541 ..     511     546 .. 0.72
   5 !    7.4   0.0    0.0031       4.7       2      31 .]     630     658 ..     629     661 .. 0.89
   6 !    8.2   0.3    0.0018       2.6       6      28 ..     757     779 ..     752     786 .. 0.89
   7 ?   -2.6   0.1         5   7.4e+03       5      19 ..     806     821 ..     804     822 .. 0.82
   8 ?    4.4   0.0      0.03        44       1      28 [.     869     896 ..     869     903 .. 0.90
   9 ?    1.5   0.0      0.24   3.6e+02      14      28 ..     967     981 ..     967     988 .. 0.87
  10 ?   -1.2   0.1       1.9   2.8e+03       5      26 ..     996    1017 ..     993    1020 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6.8e-05
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalrkalg 31 
                 +++e+F  fDk ++G++++ ++r++l+ ++g
  EFC38896.1 178 RINEFFIDFDKLRSGFVSIPQFRRCLS-SFG 207
                 589***********************9.765 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.035
   EF-hand_6   3 reaFklfDkdgdGkidaeElrkal 26 
                 +  Fk fD  + G ++++++ +++
  EFC38896.1 290 KNYFKDFDPLNHGAVTRSQFLQCI 313
                 678*****************9986 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00019
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkal 26 
                 l+e F+ fD+ ++G+i+++++++ l
  EFC38896.1 389 LDESFRDFDRLRTGFITKAQFMSTL 413
                 7889*****************9877 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.11
   EF-hand_6   5 aFklfDkdgdG.....kidaeElrkal 26 
                 +F+ fDk++ G     +++++ + +al
  EFC38896.1 515 FFQDFDKTKKGtystdHVTRARFERAL 541
                 8*******9996565666666666666 PP

  == domain 5  score: 7.4 bits;  conditional E-value: 0.0031
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalrkalg 31 
                 l+e+ + fD  ++ +i+ +++r+al+ ++g
  EFC38896.1 630 LEEFMRDFDPLRSHEITEKQFRSALN-MGG 658
                 77888999999**************9.665 PP

  == domain 6  score: 8.2 bits;  conditional E-value: 0.0018
   EF-hand_6   6 FklfDkdgdGkidaeElrkalrk 28 
                 F+ fDk + Gki+  +++++l k
  EFC38896.1 757 FEDFDKLRRGKISETQFIQCLDK 779
                 999*****************984 PP

  == domain 7  score: -2.6 bits;  conditional E-value: 5
   EF-hand_6   5 aFklf.DkdgdGkida 19 
                  Fk + D+d++  +d+
  EFC38896.1 806 YFKFIqDVDKNERVDR 821
                 5888889***999986 PP

  == domain 8  score: 4.4 bits;  conditional E-value: 0.03
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalrk 28 
                 +l+e+F  fDk + + + ++ +r al++
  EFC38896.1 869 RLKEFFADFDKLRHNVVPKAKFRTALSM 896
                 689*********************9996 PP

  == domain 9  score: 1.5 bits;  conditional E-value: 0.24
   EF-hand_6  14 dGkidaeElrkalrk 28 
                 ++++d +El ++l+k
  EFC38896.1 967 SNEVDGNELNAILKK 981
                 5789*********95 PP

  == domain 10  score: -1.2 bits;  conditional E-value: 1.9
   EF-hand_6    5 aFklfDkdgdGkidaeElrkal 26  
                   F+ +Dk +   +++ ++ ++l
  EFC38896.1  996 YFQDYDKLRKLRVTKTQFASIL 1017
                  6999999999999999999988 PP

>> PRK  Phosphoribulokinase / Uridine kinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.8   0.0   4.5e-12   6.7e-09       1     139 [.      34     170 ..      34     180 .. 0.88
   2 ?   -3.2   0.1         4   5.9e+03      22      93 ..     518     592 ..     510     603 .. 0.60

  Alignments for each domain:
  == domain 1  score: 35.8 bits;  conditional E-value: 4.5e-12
         PRK   1 vIgvagsSGaGkttvarklekifgre.kvkaaeiegdsflrldraekdleleerkrakekevsflspeandfdllyevlkelkegkkvdkpiYshetee 98 
                 +Ig+ g  G+Gkt+v + ++k + +e k++ +++ +d f+ + r ++   +e+ k+a++++   +  +   f++l e +k+    +kv+ p ++h  ++
  EFC38896.1  34 LIGIFGTPGSGKTSVCQDMKKYLTEElKINCQVVPMDGFHYYRRELDM--MEDPKHAHSRRGAPFTFNDLAFKNLLENIKHS-PNQKVSAPSFDHGVGD 129
                 69*********************9772455566689999999988875..5788888888999999999*********9975.5689************ PP

         PRK  99 aapdkeeliegadvlviEGlhalydervaelldlkiyvdis 139
                    d  ++ ++++++++EG + +   +v  l d+ iy+ ++
  EFC38896.1 130 PIEDDIHVEANQSIIIVEGNYLATWPNVTPLFDILIYIHTQ 170
                 9999*********************************9886 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 4
         PRK  22 ifgrekvkaaeiegdsflrldraekdlel...eerkrakekevsflspeandfdllyevlkelkegkkvdkpiYs 93 
                  f ++k+ + + +++   r++ra++   +   ++++   e++++ l+    +++   e + e  +  + +++ Y+
  EFC38896.1 518 DFDKTKKGTYSTDHVTRARFERALHMSGInltQDEYTILEEKYDDLGKGDVNYKMFLEDVDEILQNSNFNTRDYD 592
                 555445554455555555555555444331114555556777777777777777777777777777777777775 PP

>> EF-hand_11  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.1    0.0021       3.1      21      84 ..     178     241 ..     158     261 .. 0.78
   2 ?    3.4   0.1     0.095   1.4e+02      17      49 ..     284     317 ..     268     353 .. 0.68
   3 ?    5.4   0.5     0.022        33       9      82 ..     376     455 ..     369     461 .. 0.75
   4 ?    3.6   0.2     0.084   1.3e+02       5      81 ..     495     576 ..     491     590 .. 0.78
   5 !    8.4   0.1    0.0025       3.8      26      84 ..     634     693 ..     623     703 .. 0.85
   6 !   15.0   0.1   2.3e-05     0.034       7      83 ..     738     814 ..     733     828 .. 0.89
   7 ?    3.3   0.0       0.1   1.5e+02      23      48 ..     871     896 ..     851     928 .. 0.72
   8 ?    1.6   0.2      0.34     5e+02       7      58 ..     978    1029 ..     973    1055 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0021
                 HHHHHHHHH-TT-SSEE-HHHHHHHHHHHT----HHHHHHHHHTS-B-TTS-EEHHHHHHHHCS CS
  EF-hand_11  21 aivqefenfdtlksntvsreefraictrrvqiltdeqfdrlwselpvnakgrlkyqdflsklsi 84 
                  i + f +fd l+s  vs  +fr   +     l d +fd+l s +   +  +++y +f + +  
  EFC38896.1 178 RINEFFIDFDKLRSGFVSIPQFRRCLSSFGMELKDADFDKLVSRFIDSSVNKVNYIQFATEIDK 241
                 35555789***************988888889***********999999999999999877655 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.095
                 HSHHHHHHHHHHH-TT-SSEE-HHHHHH.HHHHH CS
  EF-hand_11  17 shyhaivqefenfdtlksntvsreefra.ictrr 49 
                 ++ h i + f++fd l+  +v+r +f   i  r+
  EFC38896.1 284 TQGHIIKNYFKDFDPLNHGAVTRSQFLQcIPFRN 317
                 56799999****************9954133343 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.022
                 HHHHHHHHHSHHHHHHHHHHH-TT-SSEE-HHHHHHH...HHHHT----HHHHHHHHHTS-B...-TTS-EEHHHHHHHH CS
  EF-hand_11   9 arlqkavashyhaivqefenfdtlksntvsreefrai...ctrrvqiltdeqfdrlwselpv...nakgrlkyqdflskl 82 
                   ++ka+  +   + + f +fd l++  +++ +f +     + +   + + q+d l ++       +  r+ yq+fl ++
  EFC38896.1 376 KEIKKALIKYRIKLDESFRDFDRLRTGFITKAQFMSTlgaIKFHKMAFNQTQLDMLAEKYRTedhHSESRVSYQEFLNNV 455
                 56888988888888999*****************9852113345556778899999887765111577899999999875 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.084
                 HHHHHHHHHHHHHSHHHHHHHHHHH-TT-SSEE-HHHH.HHHHHHHT--....--HHHHHHHHHTS-B-TTS-EEHHHHHHH CS
  EF-hand_11   5 rdilarlqkavashyhaivqefenfdtlksntvsreef.raictrrvqi....ltdeqfdrlwselpvnakgrlkyqdflsk 81 
                  d++ ++   v+     +   f++fd  k  t s +   ra  +r + +    lt++++  l ++     kg ++y+ fl  
  EFC38896.1 495 NDVINKVSEIVSNRRVFMKPFFQDFDKTKKGTYSTDHVtRARFERALHMsginLTQDEYTILEEKYDDLGKGDVNYKMFLED 576
                 588899999998888888888999**99999988886436667776654333478888999998899899999999999875 PP

  == domain 5  score: 8.4 bits;  conditional E-value: 0.0025
                 HHHH-TT-SSEE-HHHHHHHHHHHT----HHHHHHHHHTS-B.-TTS-EEHHHHHHHHCS CS
  EF-hand_11  26 fenfdtlksntvsreefraictrrvqiltdeqfdrlwselpv.nakgrlkyqdflsklsi 84 
                 + +fd l+s  ++ ++fr+  +     +td++ ++l se+     kg ++y+ f   + +
  EFC38896.1 634 MRDFDPLRSHEITEKQFRSALNMGGIDMTDKENEQLISEFKSpTKKGFVNYRKFCDTINS 693
                 368*******************998899***********987246799999999877654 PP

  == domain 6  score: 15.0 bits;  conditional E-value: 2.3e-05
                 HHHHHHHHHHHSHHHHHHHHHHH-TT-SSEE-HHHHHHHHHHHT----HHHHHHHHHTS-B-TTS-EEHHHHHHHHC CS
  EF-hand_11   7 ilarlqkavashyhaivqefenfdtlksntvsreefraictrrvqiltdeqfdrlwselpvnakgrlkyqdflskls 83 
                 +l +lq av +   a+  +fe+fd l+   +s  +f    ++  + lt+e++  l +     + g ++y  f+  + 
  EFC38896.1 738 LLGKLQYAVKTRGIAMKVNFEDFDKLRRGKISETQFIQCLDKLFNFLTQEDYRLLQNAYFEPTSGYVNYFKFIQDVD 814
                 78899***********************************************9999999999999999999988765 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.1
                 HHHHHHH-TT-SSEE-HHHHHHHHHH CS
  EF-hand_11  23 vqefenfdtlksntvsreefraictr 48 
                  + f +fd l+ n v + +fr+  + 
  EFC38896.1 871 KEFFADFDKLRHNVVPKAKFRTALSM 896
                 344789***************86544 PP

  == domain 8  score: 1.6 bits;  conditional E-value: 0.34
                  HHHHHHHHHHHSHHHHHHHHHHH-TT-SSEE-HHHHHHHHHHHT----HHHH CS
  EF-hand_11    7 ilarlqkavashyhaivqefenfdtlksntvsreefraictrrvqiltdeqf 58  
                  il ++    a   + ++  f+++d l+   v++ +f +i +     l d+++
  EFC38896.1  978 ILKKVATKAAVMQQILTAYFQDYDKLRKLRVTKTQFASILDFLKFHLNDKEL 1029
                  5555555556666778899*******************98876666666655 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.6e-06    0.0053       1      22 [.      35      56 ..      35     149 .. 0.64
   2 ?   -1.4   0.1       2.1   3.2e+03      52      82 ..     470     501 ..     435     554 .. 0.67

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.6e-06
      AAA_18  1 IlltGtpGvGKttlakeLskrl 22
                I++ GtpG+GKt++++  +k l
  EFC38896.1 35 IGIFGTPGSGKTSVCQDMKKYL 56
                89*************9986653 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.1
      AAA_18  52 ldedkldklldaleenss..aleegknlvidgh 82 
                  + ++++++++++++n +  ++e++++ vi  +
  EFC38896.1 470 KKFHQQNNIVKLNRKNLEseKEEKCND-VINKV 501
                 333344444444444444555555555.55544 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.1       0.2   2.9e+02      41      67 ..     174     200 ..     161     204 .. 0.74
   2 ?    4.6   0.5     0.031        46       4      68 ..     179     311 ..     176     313 .. 0.49
   3 ?    2.4   0.0      0.15   2.2e+02       5      26 ..     290     311 ..     288     379 .. 0.67
   4 !   19.4   0.8   7.4e-07    0.0011       3      68 ..     388     453 ..     386     456 .. 0.79
   5 ?   -1.0   0.0       1.7   2.6e+03      46      59 ..     512     525 ..     474     542 .. 0.76
   6 ?    2.0   1.8      0.19   2.9e+02      45      69 ..     627     653 ..     515     655 .. 0.80
   7 ?    3.3   0.2     0.077   1.1e+02       5      63 ..     631     684 ..     626     690 .. 0.59
   8 ?    2.8   2.2      0.11   1.7e+02       8      36 ..     757     819 ..     752     895 .. 0.56
   9 ?    1.2   0.1      0.34   5.1e+02       2      49 ..     868     909 ..     867     924 .. 0.85
  10 ?    2.2   1.1      0.17   2.6e+02       2      49 ..     990    1032 ..     989    1052 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.2
   EF-hand_7  41 lsdeelellfkefDtdkdGvisfdEFl 67 
                   +  + ++f +fD+ ++G +s   F+
  EFC38896.1 174 EKRLRINEFFIDFDKLRSGFVSIPQFR 200
                 344458899999999999999988887 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.031
   EF-hand_7   4 lkeaFkelDtdgdgyldkeellr................llrkifqga................................................... 35 
                 + e F  +D+ ++g+++  +++r                l+ +++++                                                    
  EFC38896.1 179 INEFFIDFDKLRSGFVSIPQFRRclssfgmelkdadfdkLVSRFIDSSvnkvnyiqfateidkgmekdpkletlnstellksqkpqlsateelnilyek 277
                 556677777777777777777763333333333333333333333333555555555555555555555555555444444444444444333333333 PP

   EF-hand_7  36 ..gegsklsdeelellfkefDtdkdGvisfdEFlk 68 
                    e++    + ++  fk+fD  + G ++++ Fl+
  EFC38896.1 278 lrWEAKT-QGHIIKNYFKDFDPLNHGAVTRSQFLQ 311
                 3222222.334477777777777777777777765 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.15
   EF-hand_7   5 keaFkelDtdgdgyldkeellr 26 
                 k  Fk +D  ++g ++++++l+
  EFC38896.1 290 KNYFKDFDPLNHGAVTRSQFLQ 311
                 4556666666677666666443 PP

  == domain 4  score: 19.4 bits;  conditional E-value: 7.4e-07
   EF-hand_7   3 klkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkef...DtdkdGvisfdEFlk 68 
                 kl e F+ +D+ ++g+++k+++++ l +i+ +   +++  +++l+ l ++    D+++  ++s++EFl+
  EFC38896.1 388 KLDESFRDFDRLRTGFITKAQFMSTLGAIKFH-KMAFN--QTQLDMLAEKYrteDHHSESRVSYQEFLN 453
                 68899******************977776644.44444..45566666666555*************86 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 1.7
   EF-hand_7  46 lellfkefDtdkdG 59 
                 ++ +f++fD++k G
  EFC38896.1 512 MKPFFQDFDKTKKG 525
                 56689999999988 PP

  == domain 6  score: 2.0 bits;  conditional E-value: 0.19
   EF-hand_7  45 e..lellfkefDtdkdGvisfdEFlkl 69 
                    le+++++fD  ++++i+   F+ +
  EFC38896.1 627 RirLEEFMRDFDPLRSHEITEKQFRSA 653
                 134899999999999999999999865 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.077
   EF-hand_7   5 keaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkef.DtdkdGvisf 63 
                 +e  + +D  ++  +++ +++++l         g +++d+e e+l+ ef   +k G +++
  EFC38896.1 631 EEFMRDFDPLRSHEITEKQFRSALN------MGGIDMTDKENEQLISEFkSPTKKGFVNY 684
                 3444556666666666666666666......66666677666666666655555555555 PP

  == domain 8  score: 2.8 bits;  conditional E-value: 0.11
   EF-hand_7   8 FkelDtdgdgyldkeellrllrkifqga..................................g 36 
                 F+ +D+ ++g+++++++ + l k+f +                                    
  EFC38896.1 757 FEDFDKLRRGKISETQFIQCLDKLFNFLtqedyrllqnayfeptsgyvnyfkfiqdvdknerV 819
                 888888888888888844444444444455455554443333333333333333333333330 PP

  == domain 9  score: 1.2 bits;  conditional E-value: 0.34
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelell 49 
                 ++lke F  +D+ +++ + k+ ++ +l         + +ls++e++ll
  EFC38896.1 868 TRLKEFFADFDKLRHNVVPKAKFRTALS------MAKLNLSEQEIQLL 909
                 689999******9999999999998888......77777788888865 PP

  == domain 10  score: 2.2 bits;  conditional E-value: 0.17
   EF-hand_7    2 eklkea.FkelDtdgdgyldkeellrllrkifqgagegsklsdeelell 49  
                  +++ +a F+ +D+ +  +++k+++ ++l         +++l d+el+ l
  EFC38896.1  990 QQILTAyFQDYDKLRKLRVTKTQFASILD------FLKFHLNDKELRVL 1032
                  5788888****************998777......66666666666554 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   6.1e-06    0.0091       1      33 [.      37      70 ..      37      84 .. 0.84
   2 ?   -3.0   0.1       3.4   5.1e+03     156     214 ..     851     915 ..     846     926 .. 0.62

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 6.1e-06
  ATP_bind_1  1 vvGpaGsGKttfvgalseile.lrgrsvavvNLD 33
                + G++GsGKt+ ++ + ++l+ + + +++vv +D
  EFC38896.1 37 IFGTPGSGKTSVCQDMKKYLTeELKINCQVVPMD 70
                68****************975156999****999 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 3.4
  ATP_bind_1 156 elPhvvvlnkfDllkeklekeleffedvealslllekee.......ekykklaeaiaelleefalv 214
                 e+  v+   + D++k ++++  eff d+++l+     +         +  +l e+  +lle+++ v
  EFC38896.1 851 EISNVIYKATSDIVK-SRTRLKEFFADFDKLRHNVVPKAkfrtalsMAKLNLSEQEIQLLEDYYKV 915
                 566666777778877.45566788899988876443333366665533344455555666666665 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0017       2.6       2      28 ..     179     205 ..     178     206 .. 0.92
   2 ?    0.9   0.0      0.27     4e+02       2      25 ..     289     312 ..     288     314 .. 0.88
   3 !    8.4   0.1    0.0011       1.7       2      26 ..     389     413 ..     388     416 .. 0.90
   4 ?    0.2   0.2      0.48   7.1e+02       5      16 ..     515     526 ..     512     526 .. 0.88
   5 ?    4.5   0.0      0.02        30       2      27 ..     630     655 ..     629     657 .. 0.92
   6 ?    4.1   0.2     0.027        40       6      28 ..     757     779 ..     753     780 .. 0.89
   7 ?   -3.9   0.1       9.6   1.4e+04       7      12 ..     811     816 ..     808     820 .. 0.56
   8 ?   -0.9   0.7         1   1.6e+03       2      11 ..     870     879 ..     869     879 .. 0.91

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0017
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 ++e+F +fDk ++G++++ +f+++l++
  EFC38896.1 179 INEFFIDFDKLRSGFVSIPQFRRCLSS 205
                 7899********************986 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.27
                 HHHHHHHHTTTSSSEEEHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkel 25 
                 +k+ F++fD  + G +++++f+++
  EFC38896.1 289 IKNYFKDFDPLNHGAVTRSQFLQC 312
                 7889*****999999999999987 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0011
                 HHHHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkell 26 
                 l+e Fr+fD+ ++G+I++ +f++ l
  EFC38896.1 389 LDESFRDFDRLRTGFITKAQFMSTL 413
                 89*******************9865 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.48
                 HHHHHTTTSSSE CS
   EF-hand_1   5 iFrefDkDgdGk 16 
                 +F++fDk + G+
  EFC38896.1 515 FFQDFDKTKKGT 526
                 69******9996 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.02
                 HHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellk 27 
                 l+e++r+fD  ++  I+ ++f+++l+
  EFC38896.1 630 LEEFMRDFDPLRSHEITEKQFRSALN 655
                 799********************997 PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.027
                 HHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   6 FrefDkDgdGkIdfeEfkellkk 28 
                 F++fDk + GkI+  +f+++l k
  EFC38896.1 757 FEDFDKLRRGKISETQFIQCLDK 779
                 899999999**********9976 PP

  == domain 7  score: -3.9 bits;  conditional E-value: 9.6
                 HHHTTT CS
   EF-hand_1   7 refDkD 12 
                 +++Dk+
  EFC38896.1 811 QDVDKN 816
                 555555 PP

  == domain 8  score: -0.9 bits;  conditional E-value: 1
                 HHHHHHHHTT CS
   EF-hand_1   2 lkeiFrefDk 11 
                 lke+F++fDk
  EFC38896.1 870 LKEFFADFDK 879
                 89*******7 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.0   5.5e-05     0.082       4      38 ..      31      70 ..      27     151 .. 0.72
   2 ?    0.6   0.0      0.42   6.3e+02      37      91 ..     484     546 ..     469     598 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 5.5e-05
      AAA_22  4 tagilvvtGesGtGKTtllrrlleqldeeakaee.....e 38
                ++ ++ ++G +G+GKT +++ +++ l+ee k++       
  EFC38896.1 31 QRLLIGIFGTPGSGKTSVCQDMKKYLTEELKINCqvvpmD 70
                677888*****************99987665543555550 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.42
      AAA_22  37 e........erpevv.fvtlpsstsskdllrellralglelkaerlsseell.ealeqalrarav 91 
                 +        ++ +v+ +v   +s+ ++ +++ ++++++  +k+ + s++++  +++e+al+  + 
  EFC38896.1 484 KnlesekeeKCNDVInKVSEIVSN-RRVFMKPFFQDFDKTKKG-TYSTDHVTrARFERALHMSGI 546
                 233333344677777777777777.9999*********99999.999999999999999998876 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   7.7e-05      0.12      25      65 ..      33      69 ..      15      97 .. 0.83
   2 ?   -1.5   0.0       1.9   2.8e+03      53      88 ..     286     325 ..     274     401 .. 0.59
   3 ?   -2.1   0.0         3   4.5e+03      52      98 ..     749     797 ..     738     870 .. 0.63
   4 ?   -3.0   0.0       5.4     8e+03      80     127 ..     926     983 ..     904     999 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 7.7e-05
      AAA_16 25 elvllsGesGvGKsslvrellralekdggiflrgkcdqles 65
                 l+ + G +G+GK+s+ +  +++l+++    l+ +c+  ++
  EFC38896.1 33 LLIGIFGTPGSGKTSVCQDMKKYLTEE----LKINCQVVPM 69
                566789*********************....9999998833 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.9
      AAA_16  53 giflrgkcdql....esaipysalaqalareellrqllde 88 
                 g+ ++  ++++    + a+++s+++q++ ++ l +++l  
  EFC38896.1 286 GHIIKNYFKDFdplnHGAVTRSQFLQCIPFRNLNAEELHL 325
                 5555555555544444446667777777665555444433 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 3
      AAA_16  52 ggiflrgkcdql...esa.ipysalaqalareellrqlldeaesaeleawr 98 
                 +gi+++ +++++   +++ i+  +++q+l   +l++ l +e+   +++a+ 
  EFC38896.1 749 RGIAMKVNFEDFdklRRGkISETQFIQCL-D-KLFNFLTQEDYRLLQNAYF 797
                 45555555555522244423335588888.3.6888888875555555444 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 5.4
      AAA_16  80 ellrqlldeaesaeleawrekleealaavpelagaea..........srllellkrll 127
                 +l+++++++  ++ le +++k  e+++a p+ + +++          + l++ lk+ +
  EFC38896.1 926 SLCEEVDRAFVENRLEKFPTKTAESFQARPSYPLKSHipeisnevdgNELNAILKKVA 983
                 5555566665556666666666666663333333333334444445556666665555 PP

>> FGAR-AT_linker  Formylglycinamide ribonucleotide amidotransferase linker domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.76   1.1e+03       7      28 ..     205     224 ..     201     245 .. 0.80
   2 ?    2.8   0.0      0.12   1.7e+02       8      28 ..     544     564 ..     538     570 .. 0.85
   3 ?   -2.0   0.0       3.7   5.5e+03      12      24 ..     784     796 ..     782     806 .. 0.84
   4 ?    6.0   0.0     0.012        18       8      28 ..     897     916 ..     891     929 .. 0.81
   5 ?    0.3   0.0      0.69     1e+03       9      25 ..    1021    1037 ..    1016    1045 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.76
  FGAR-AT_linker   7 elglaLsdeEidylqeafeklg 28 
                     + g+ L+d+++d+l++ f  + 
      EFC38896.1 205 SFGMELKDADFDKLVSRF--ID 224
                     5799************99..33 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.12
  FGAR-AT_linker   8 lglaLsdeEidylqeafeklg 28 
                      g  L+++E+  l+e + +lg
      EFC38896.1 544 SGINLTQDEYTILEEKYDDLG 564
                     5889************98887 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 3.7
  FGAR-AT_linker  12 LsdeEidylqeaf 24 
                     L++e+++ lq+a+
      EFC38896.1 784 LTQEDYRLLQNAY 796
                     99*********98 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.012
  FGAR-AT_linker   8 lglaLsdeEidylqeafeklg 28 
                      +l Ls++Ei+ l+++++ + 
      EFC38896.1 897 AKLNLSEQEIQLLEDYYK-VD 916
                     689*************94.44 PP

  == domain 5  score: 0.3 bits;  conditional E-value: 0.69
  FGAR-AT_linker    9 glaLsdeEidylqeafe 25  
                      ++ L+d+E + lq+++e
      EFC38896.1 1021 KFHLNDKELRVLQKHYE 1037
                      578***********995 PP

>> RST  RCD1-SRO-TAF4 (RST) plant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0         2     3e+03      27      47 ..     288     311 ..     282     313 .. 0.66
   2 ?   -0.7   0.0       0.9   1.3e+03      30      49 ..     394     413 ..     387     416 .. 0.87
   3 ?   -3.7   0.0       7.8   1.2e+04      35      58 ..     441     464 ..     425     466 .. 0.68
   4 ?   -1.6   0.0       1.8   2.6e+03      20      46 ..     548     574 ..     537     580 .. 0.82
   5 ?    5.3   0.1     0.012        18      29      49 ..     757     777 ..     745     781 .. 0.86
   6 ?   -2.0   0.0       2.4   3.6e+03      16      38 ..     780     802 ..     777     813 .. 0.73
   7 ?    1.1   0.0      0.25   3.7e+02       5      33 ..     886     914 ..     883     916 .. 0.89
   8 ?    1.7   0.1      0.17   2.5e+02      30      46 ..     998    1014 ..     975    1017 .. 0.78
   9 ?    7.9   0.2    0.0019       2.8       8      36 ..    1012    1040 ..    1007    1056 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2
         RST  27 llqkhYedl...kkkkIsreefvr 47 
                 +++++++d+     + ++r++f++
  EFC38896.1 288 IIKNYFKDFdplNHGAVTRSQFLQ 311
                 566666665222688999999987 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.9
         RST  30 khYedlkkkkIsreefvrkl 49 
                 +++++l+ + I++ +f+  l
  EFC38896.1 394 RDFDRLRTGFITKAQFMSTL 413
                 679999**********9876 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 7.8
         RST  35 lkkkkIsreefvrklRsivGDklL 58 
                 + + ++s +ef+  + s+  Dk L
  EFC38896.1 441 HSESRVSYQEFLNNVYSVFNDKGL 464
                 567788888888888777777655 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 1.8
         RST  20 lpkskmdllqkhYedlkkkkIsreefv 46 
                 l +++  +l++ Y+dl k+ ++ + f+
  EFC38896.1 548 LTQDEYTILEEKYDDLGKGDVNYKMFL 574
                 788999999******999988776665 PP

  == domain 5  score: 5.3 bits;  conditional E-value: 0.012
         RST  29 qkhYedlkkkkIsreefvrkl 49 
                  +++++l+++kIs  +f++ l
  EFC38896.1 757 FEDFDKLRRGKISETQFIQCL 777
                 5789**************976 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 2.4
         RST  16 lskklpkskmdllqkhYedlkkk 38 
                 l ++l +++  llq+ Y +  ++
  EFC38896.1 780 LFNFLTQEDYRLLQNAYFEPTSG 802
                 678999********999765555 PP

  == domain 7  score: 1.1 bits;  conditional E-value: 0.25
         RST   5 pwvpFpmLlaalskklpkskmdllqkhYe 33 
                 p  +F + l++ + +l++++++ll+ +Y+
  EFC38896.1 886 PKAKFRTALSMAKLNLSEQEIQLLEDYYK 914
                 55679999999999**************8 PP

  == domain 8  score: 1.7 bits;  conditional E-value: 0.17
         RST   30 khYedlkkkkIsreefv 46  
                  ++Y++l+k ++++ +f 
  EFC38896.1  998 QDYDKLRKLRVTKTQFA 1014
                  57999**********95 PP

  == domain 9  score: 7.9 bits;  conditional E-value: 0.0019
         RST    8 pFpmLlaalskklpkskmdllqkhYedlk 36  
                  +F   l+ l+ +l+ ++  +lqkhYed +
  EFC38896.1 1012 QFASILDFLKFHLNDKELRVLQKHYEDER 1040
                  7999**********************854 PP

>> DUF5446  Family of unknown function (DUF5446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.1    0.0058       8.6      17      38 ..     367     388 ..     365     397 .. 0.84
   2 ?    0.4   0.4       0.5   7.5e+02      34      52 ..     485     503 ..     477     507 .. 0.82
   3 ?   -1.2   0.1       1.5   2.3e+03      24      47 ..     646     669 ..     642     672 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0058
     DUF5446  17 iEeeltevEkelseavneteae 38 
                 iEe+++e+Eke+ +a+ + ++ 
  EFC38896.1 367 IEEQVDEIEKEIKKALIKYRIK 388
                 9************999887765 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.5
     DUF5446  34 eteaekeekeeerldllek 52 
                 ++e ekeek +++++++ +
  EFC38896.1 485 NLESEKEEKCNDVINKVSE 503
                 6799**********98865 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.5
     DUF5446  24 vEkelseavneteaekeekeeerl 47 
                  Ek+  +a+n+  + +  ke+e l
  EFC38896.1 646 TEKQFRSALNMGGIDMTDKENEQL 669
                 59999************9999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1059 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1317  (0.0734564); expected 358.6 (0.02)
Passed bias filter:                      605  (0.0337442); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.90u 0.35s 00:00:01.25 Elapsed: 00:00:00.53
# Mc/sec: 6051.49
//
Query:       EFC38897.1  [L=286]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.8e-05   24.4   0.0    8.4e-05   22.9   0.0    1.8  1  Helicase_C  Helicase conserved C-terminal domain
    0.00028   20.7   0.0     0.0065   16.3   0.0    2.2  2  DEAD        DEAD/DEAH box helicase


Domain annotation for each model (and alignments):
>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.0   9.4e-09   8.4e-05      13     110 ..     143     237 ..     130     238 .. 0.71

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 9.4e-09
                 TTTTSEEEEEESSHHHHHHHHHHHHHTTSTEEEESTTSTHHHHH...HHHHHHHTTSSSEEEESGGGTSSSTSTTESEEEESSSSSSHHHHHHHHTTSS CS
  Helicase_C  13 eeeggkilifvntidrlekvklllekkgikvavlhgelpqnere...eileqfnkgesdvLiatdvaerGidipkvnlVinfdlprnvtsyiqriGRtg 108
                  ++ + ++ f+n+ +r+   + +++ k    ++ + ++  ++ +   e +++f   ++  Li t     Gid+p +n++++fd+  + t+   r+GR++
  EFC38897.1 143 FNISDFCIFFCNSHNRVA--QSFNSLK---EIYPTLQIAPQQYDvlkERFHSF-TRSTIHLIGTEEDWLGIDVPWCNCIVHFDVVCDETKSRLRSGRCA 235
                 567777899******997..6662222...22333334444444001555555.567779*************************************** PP

                 ST CS
  Helicase_C 109 Ra 110
                 R+
  EFC38897.1 236 RF 237
                 *6 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   7.2e-07    0.0065      96     164 ..      29      87 ..       5      91 .. 0.71
   2 ?    1.9   0.0     0.019   1.7e+02      53      83 ..     169     199 ..     163     210 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 7.2e-07
                 TTCSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHSHHHCTTSTTTSEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  96 ngvdivvgtpgrlddllstgklnlsqvrflVlDEadrlldqgfsdfinrilnqlpqitcdgklqrqviv 164
                  +++i+v+tp+  ++    +++++s++++l +DE+  +l+  f+ +++++++++    ++ + + + i+
  EFC38897.1  29 DQTRILVTTPQLALH----HNIDVSNLNILAVDEMNLMLE--FGSDCRKCIKSIF---KQLPDK-TRII 87 
                 4589******88887....4578****************9..6777777666663...333322.2444 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.019
                 EESSHHHHHHHHHHHHHHTTTSTSEEEEEET CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  53 vePtreLaeqtlnnlkkfkkyidlrvlliig 83 
                 + Pt ++a q+++ lk++++  + ++  +ig
  EFC38897.1 169 IYPTLQIAPQQYDVLKERFHSFTRSTIHLIG 199
                 679***************9985544444455 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1684.39
//
Query:       EFC38898.1  [L=667]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.7e-38  128.4  22.1    1.3e-09   37.7   0.0    9.0 10  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0     0.071   1.3e+03       8      31 ..      20      49 ..      18      53 .. 0.81
   2 !   37.7   0.0     7e-14   1.3e-09       1      41 [.     107     147 ..     107     151 .. 0.92
   3 ?   -0.7   0.0     0.067   1.2e+03      24      46 ..     158     180 ..     154     184 .. 0.53
   4 !    7.0   0.7   0.00027       4.9       1      42 [.     185     233 ..     185     245 .. 0.81
   5 ?    0.0   0.1      0.04   7.2e+02      26      36 ..     264     274 ..     241     281 .. 0.66
   6 ?    1.7   0.0     0.012   2.1e+02      15      38 ..     282     307 ..     264     319 .. 0.64
   7 ?    0.9   0.0     0.022   3.9e+02      26      47 ..     334     355 ..     318     357 .. 0.74
   8 !   35.2   0.0   4.2e-13   7.5e-09       8      49 .]     407     448 ..     405     448 .. 0.95
   9 !   20.8   0.5   1.3e-08   0.00024       1      30 [.     450     479 ..     450     482 .. 0.97
  10 !   31.3   0.0     7e-12   1.3e-07       1      47 [.     560     606 ..     560     608 .. 0.98

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.071
     DUF4116  8 avkkngsalkylseeL......knDkeivl 31
                +++kn+++ + l e+L       nD+++ l
  EFC38898.1 20 VLSKNNFHAQLLKEKLgrrmlqANDRQFEL 49
                789999999999999987777777888865 PP

  == domain 2  score: 37.7 bits;  conditional E-value: 7e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 Dr++ le+v+++gs + +l+e++k D+ei+l+Avk+n +++
  EFC38898.1 107 DRQVLLECVRNCGSEFAFLPEKFKVDREIALAAVKSNADSI 147
                 9************************************9643 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.067
     DUF4116  24 knDkeivlkAvkqngtalsyase 46 
                 ++D ei+  ++  n++  s +s+
  EFC38898.1 158 RKDPEIIAHCLMANCSLSSQVSP 180
                 55555555555555444444443 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.00027
     DUF4116   1 DrEivleavkkngs.......alkylseeLknDkeivlkAvkqngtals 42 
                 D+ ++l +v++  +        l+ +s++L     ++++++ + ++al+
  EFC38898.1 185 DEAFCLSVVERIYKpsdiyyvLLHSVSNRLLESEPFMKRIISKFPKALY 233
                 66689999999966667766666669*******************9983 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.04
     DUF4116  26 DkeivlkAvkq 36 
                  k+++lk++++
  EFC38898.1 264 TKDLILKCLQN 274
                 57899999884 PP

  == domain 6  score: 1.7 bits;  conditional E-value: 0.012
     DUF4116  15 alky..lseeLknDkeivlkAvkqng 38 
                 ++++  ++ e+ +D++i ++ +k+ g
  EFC38898.1 282 VFQKyrIPVEFEQDRDITIQQLKIGG 307
                 44444678888899999888877766 PP

  == domain 7  score: 0.9 bits;  conditional E-value: 0.022
     DUF4116  26 DkeivlkAvkqngtalsyasee 47 
                 D+ ++l  +k n +++s ++++
  EFC38898.1 334 DIKLILDVLKHNADIFSWLPDH 355
                 6677888888888888888876 PP

  == domain 8  score: 35.2 bits;  conditional E-value: 4.2e-13
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +v ++g+ l+++s++++ +keiv++A++ ++ +l+y s+eL+
  EFC38898.1 407 LVCRCGYLLRFCSPKITANKEIVMRALQTSPMSLKYTSDELK 448
                 56799***********************************97 PP

  == domain 9  score: 20.8 bits;  conditional E-value: 1.3e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeiv 30 
                 D+E+vl a+++n  a+++++ eL nDk+i+
  EFC38898.1 450 DKEVVLVAIRRNIRAIQFANLELLNDKDIC 479
                 9***************************96 PP

  == domain 10  score: 31.3 bits;  conditional E-value: 7e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 +rE+ + a++ +g  l+y++ee++nD + +  Av    +a++ya ee
  EFC38898.1 560 NREFYKFALRYDGTLLQYAPEEIRNDEQMICLAVSTRRSAFNYATEE 606
                 8*******************************************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (667 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       650  (0.0362541); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 3971.59
//
Query:       EFC38899.1  [L=466]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.062   13.6   0.0       0.16   12.3   0.0    1.7  1  AAA_22    AAA domain


Domain annotation for each model (and alignments):
>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   8.8e-06      0.16       6      56 ..     149     189 ..     147     238 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 8.8e-06
      AAA_22   6 gilvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdl 56 
                 ++ ++ G+s +GK++++++ le+          r+ v+++ l + +  +++
  EFC38899.1 149 QLAYISGPSNSGKSMSVEKALEN----------RRNVIYIPLRANMPYQNI 189
                 6789******************9..........677777777777644333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (466 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       550  (0.0306766); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 2640.37
//
Query:       EFC38900.1  [L=513]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (513 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       432  (0.024095); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2888.89
//
Query:       EFC38901.1  [L=392]
Description: member of the leucine-rich repeat protein family [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.3e-40  132.7  17.8    0.00029   20.6   0.0   10.7 11  LRR_6       Leucine Rich repeat
    3.8e-26   90.6  17.4    8.8e-10   38.2   0.6    4.8  4  LRR_8       Leucine rich repeat
    2.2e-22   78.8  20.9      2e-06   28.0   0.1    7.0  7  LRR_4       Leucine Rich repeats (2 copies)
    2.3e-13   48.7   6.1        6.6    7.7   0.3   10.0 10  LRR_1       Leucine Rich Repeat
    0.00055   19.7   3.1     0.0016   18.2   3.2    1.8  1  F-box       F-box domain
      0.004   17.0   0.7       0.01   15.7   0.2    1.9  1  F-box-like  F-box-like
  ------ inclusion threshold ------
        9.9    6.0  21.6        3.2    7.6   1.3    2.9  2  Beta_helix  Right handed beta helix region


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.0   2.4e-05     0.061       4      24 .]     108     128 ..     106     128 .. 0.88
   2 !   20.6   0.0   1.1e-07   0.00029       2      24 .]     130     152 ..     129     152 .. 0.92
   3 !   14.6   0.0   9.6e-06     0.025       4      19 ..     156     171 ..     153     176 .. 0.84
   4 !    8.7   0.0   0.00077         2       4      23 ..     181     200 ..     179     201 .. 0.90
   5 !   19.2   0.1   3.4e-07   0.00087       5      24 .]     206     225 ..     203     225 .. 0.93
   6 !   11.1   0.1   0.00014      0.35       5      22 ..     230     247 ..     227     249 .. 0.87
   7 !   13.4   0.0   2.3e-05      0.06       3      24 .]     252     273 ..     250     273 .. 0.91
   8 ?    2.8   0.0     0.062   1.6e+02       5      24 .]     278     297 ..     276     297 .. 0.88
   9 !   14.3   0.0   1.2e-05     0.031       4      23 ..     301     320 ..     299     321 .. 0.91
  10 !   16.9   0.1   1.9e-06    0.0047       5      24 .]     326     345 ..     323     345 .. 0.95
  11 ?   -3.4   0.1       5.7   1.4e+04       2       8 ..     374     380 ..     374     382 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.4e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  L  Ld++ N+IgD G++ ++
  EFC38901.1 108 RLVDLDMKMNNIGDIGVSYIS 128
                 6889*************9875 PP

  == domain 2  score: 20.6 bits;  conditional E-value: 1.1e-07
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  t+Lt+L++s+N I+ eGa+ L+
  EFC38901.1 130 LTKLTKLNVSYNRISSEGAKYLS 152
                 689****************9885 PP

  == domain 3  score: 14.6 bits;  conditional E-value: 9.6e-06
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                  Lt+Ld+s+N+Ig +G
  EFC38901.1 156 QLTYLDISHNKIGEDG 171
                 59***********988 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.00077
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+L++ +N+Ig  G++ +
  EFC38901.1 181 QLTHLNIYYNEIGVRGVKFI 200
                 69**************9976 PP

  == domain 5  score: 19.2 bits;  conditional E-value: 3.4e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++ gN IgD+G+e L+
  EFC38901.1 206 LTSLNVGGNRIGDQGIEHLM 225
                 9****************996 PP

  == domain 6  score: 11.1 bits;  conditional E-value: 0.00014
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 L  L++s N+I  eGa+ 
  EFC38901.1 230 LVDLNISNNNIRVEGAKL 247
                 889*************86 PP

  == domain 7  score: 13.4 bits;  conditional E-value: 2.3e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 t Lt L+++ N IgD+Ga+ ++
  EFC38901.1 252 TQLTNLNIRKNIIGDDGAKYIS 273
                 679***************9885 PP

  == domain 8  score: 2.8 bits;  conditional E-value: 0.062
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +Ld+  N +++ Ga+ ++
  EFC38901.1 278 LIKLDIGKNYLSNRGAKYIS 297
                 568*************9875 PP

  == domain 9  score: 14.3 bits;  conditional E-value: 1.2e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt Ld+++N+I  eGae +
  EFC38901.1 301 YLTNLDIRSNNIREEGAEFI 320
                 79***************976 PP

  == domain 10  score: 16.9 bits;  conditional E-value: 1.9e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L+L+gN I+DeG++ L+
  EFC38901.1 326 LTNLNLNGNYITDEGIKHLC 345
                 9*****************98 PP

  == domain 11  score: -3.4 bits;  conditional E-value: 5.7
       LRR_6   2 nthLteL 8  
                 n+hL +L
  EFC38901.1 374 NHHLSYL 380
                 8999988 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2   0.6   3.4e-13   8.8e-10       2      61 .]     108     167 ..     107     167 .. 0.97
   2 !   22.6   0.9   2.7e-08   6.8e-05       1      61 []     180     240 ..     180     240 .. 0.96
   3 !   25.2   1.0   3.9e-09   9.9e-06       2      61 .]     253     312 ..     252     312 .. 0.98
   4 !   23.2   0.5   1.6e-08   4.2e-05       2      57 ..     301     356 ..     300     360 .. 0.92

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 3.4e-13
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L  Ld   N++ +++ +  ++l++L+ L+ s+N++++  ++ +s +++L++Ld+s+N++
  EFC38901.1 108 RLVDLDMKMNNIGDIGVSYISNLTKLTKLNVSYNRISSEGAKYLSKMKQLTYLDISHNKI 167
                 6888999***************************************************97 PP

  == domain 2  score: 22.6 bits;  conditional E-value: 2.7e-08
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++Lt L++  N + + + ++   l++L++L+ + N++     + ++ +++L  L++s+N++
  EFC38901.1 180 RQLTHLNIYYNEIGVRGVKFIGALKQLTSLNVGGNRIGDQGIEHLMRMHQLVDLNISNNNI 240
                 68************************************99999****************97 PP

  == domain 3  score: 25.2 bits;  conditional E-value: 3.9e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++++N + + + +  + +++L  Ld++ N l+   ++ +s ++ L+ Ld+++N++
  EFC38901.1 253 QLTNLNIRKNIIGDDGAKYISEMKQLIKLDIGKNYLSNRGAKYISEMKYLTNLDIRSNNI 312
                 8*********************************************************97 PP

  == domain 4  score: 23.2 bits;  conditional E-value: 1.6e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                  Lt+Ld+++N++ + + e+   +++L+ L+L+ N +t    + + gL +L sL + 
  EFC38901.1 301 YLTNLDIRSNNIREEGAEFIGEMKQLTNLNLNGNYITDEGIKHLCGLYQLVSLSIY 356
                 59************************************888999999999999875 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.1      0.03        78      22      40 ..     105     123 ..      66     131 .. 0.79
   2 !   28.0   0.1   7.9e-10     2e-06       1      36 [.     131     167 ..     131     173 .. 0.91
   3 !   15.7   0.0     6e-06     0.015       2      38 ..     181     218 ..     180     223 .. 0.81
   4 !   15.5   1.5     7e-06     0.018       3      37 ..     230     265 ..     228     270 .. 0.81
   5 !    8.2   1.3    0.0014       3.5       1      37 [.     252     289 ..     252     291 .. 0.79
   6 !   22.3   0.6   4.8e-08   0.00012       3      38 ..     302     338 ..     300     343 .. 0.89
   7 !   12.8   1.1   4.9e-05      0.12       1      36 [.     324     360 ..     324     364 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.03
                 -TT.--EEE-.-S-----GG CS
       LRR_4  22 lpn.LkeLdLsgNnlitdld 40 
                 ++n L  Ld+  +n+i+d+ 
  EFC38901.1 105 MKNrLVDLDM-KMNNIGDIG 123
                 6777888888.777888873 PP

  == domain 2  score: 28.0 bits;  conditional E-value: 7.9e-10
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+ s N++++ +   l+k+++L++Ld+s+N +i
  EFC38901.1 131 TKLTKLNVSYNRISSEGAkyLSKMKQLTYLDISHN-KI 167
                 79*************99999999*********999.65 PP

  == domain 3  score: 15.7 bits;  conditional E-value: 6e-06
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 +L++L++  N +   +  + + l++L++L++ gN +i+d
  EFC38901.1 181 QLTHLNIYYNEIGVRGVkFIGaLKQLTSLNVGGN-RIGD 218
                 69*******9*88444475555*********778.7765 PP

  == domain 4  score: 15.5 bits;  conditional E-value: 7e-06
                 --EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   3 LevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 L  L++snN+++  +  l + +++L+ L++  N  i+
  EFC38901.1 230 LVDLNISNNNIRVEGAkLVSeMTQLTNLNIRKN-IIG 265
                 6779********766697777*********555.665 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.0014
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L+++ N + d +   ++ +++L +Ld+  N +++
  EFC38901.1 252 TQLTNLNIRKNIIGDDGAkyISEMKQLIKLDIGKN-YLS 289
                 68********99**855575445*********555.774 PP

  == domain 6  score: 22.3 bits;  conditional E-value: 4.8e-08
                 --EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   3 LevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 L++Ld+++N++++ +  + + +++L+ L+L+gN +itd
  EFC38901.1 302 LTNLDIRSNNIREEGAeFIGeMKQLTNLNLNGN-YITD 338
                 89**********988896666*********999.9987 PP

  == domain 7  score: 12.8 bits;  conditional E-value: 4.9e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L+L++N +td +   l +l +L +L++  N+ i
  EFC38901.1 324 KQLTNLNLNGNYITDEGIkhLCGLYQLVSLSI-YNTGI 360
                 58*************98888668*********.87655 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       1.4   3.5e+03       3      23 .]     110     130 ..     108     130 .. 0.81
   2 !    6.4   0.0    0.0068        18       1      22 [.     132     153 ..     132     154 .. 0.86
   3 !    6.7   0.0    0.0053        14       1      17 [.     156     172 ..     156     178 .. 0.76
   4 ?    4.1   0.0     0.038        97       1      14 [.     181     194 ..     181     203 .. 0.78
   5 ?    4.6   0.0     0.027        68       1      19 [.     205     223 ..     205     227 .. 0.79
   6 ?    2.6   0.0      0.12   3.2e+02       2      12 ..     230     240 ..     229     251 .. 0.78
   7 ?    2.4   0.0      0.14   3.7e+02       2      20 ..     254     272 ..     253     275 .. 0.79
   8 ?    2.6   0.0      0.12   3.1e+02       2      20 ..     278     296 ..     277     299 .. 0.79
   9 ?    2.1   0.0      0.18   4.6e+02       2      12 ..     302     312 ..     301     322 .. 0.78
  10 !    7.7   0.3    0.0026       6.6       2      23 .]     326     347 ..     325     347 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.4
       LRR_1   3 rhLdLsnnpllglppnsfqnL 23 
                   Ld+  n++++++ ++++nL
  EFC38901.1 110 VDLDMKMNNIGDIGVSYISNL 130
                 568999999999999999887 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0068
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++L++s+n++++ ++ ++++
  EFC38901.1 132 KLTKLNVSYNRISSEGAKYLSK 153
                 79*********99888887765 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0053
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++Ld+s+n ++  ++
  EFC38901.1 156 QLTYLDISHNKIGEDGS 172
                 599*******9955554 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.038
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L+hL++ +n ++ 
  EFC38901.1 181 QLTHLNIYYNEIGV 194
                 59********9854 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.027
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L++L++++n++++ ++++
  EFC38901.1 205 QLTSLNVGGNRIGDQGIEH 223
                 599********97666555 PP

  == domain 6  score: 2.6 bits;  conditional E-value: 0.12
       LRR_1   2 LrhLdLsnnpl 12 
                 L  L++snn++
  EFC38901.1 230 LVDLNISNNNI 240
                 5569*****98 PP

  == domain 7  score: 2.4 bits;  conditional E-value: 0.14
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ L+++ n++++ ++ ++
  EFC38901.1 254 LTNLNIRKNIIGDDGAKYI 272
                 899*******987766655 PP

  == domain 8  score: 2.6 bits;  conditional E-value: 0.12
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L +Ld++ n l++ ++ ++
  EFC38901.1 278 LIKLDIGKNYLSNRGAKYI 296
                 899*******987777665 PP

  == domain 9  score: 2.1 bits;  conditional E-value: 0.18
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ Ld+++n++
  EFC38901.1 302 LTNLDIRSNNI 312
                 889***99997 PP

  == domain 10  score: 7.7 bits;  conditional E-value: 0.0026
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ L+L++n +++ ++ ++++L
  EFC38901.1 326 LTNLNLNGNYITDEGIKHLCGL 347
                 899*************999987 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   3.2   6.3e-07    0.0016       3      45 ..      25      67 ..      24      70 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.3e-07
                HHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHH CS
       F-box  3 lsrLPsevlrhILerLplsdllalrrVSkgwrilidsdrlwck 45
                l+  +++ + +IL++L+ + +l++ + Sk w ++i + ++   
  EFC38901.1 25 LLIFSDDSIFEILSFLDVKFILNCTLISKQWLNVISERSRFSL 67
                566799*****************************98877665 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.2     4e-06      0.01       9      36 ..      33      60 ..      30      65 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 4e-06
  F-box-like  9 LlqIFsyLppsdLlrlalVCrrWrrval 36
                + +I+s+L+ + +l+++l +++W +v++
  EFC38901.1 33 IFEILSFLDVKFILNCTLISKQWLNVIS 60
                679**********************995 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1  13.2     0.059   1.5e+02      17     136 ..     137     266 ..      47     277 .. 0.66
   2 ?    7.6   1.3    0.0013       3.2      96     139 ..     298     344 ..     279     374 .. 0.65

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.059
                 EEES-..SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---..........................SEEE-TT--S--EEES-E CS
  Beta_helix  17 tisns..ggyGiylrgssnvvienneiannsgsGiyilgs.snntisnntisdnn..........................gggialfgasnnlienne 86 
                 ++s +  ++ G +  + ++                    + ++  is+n+i + +                           +  al++     + +n+
  EFC38901.1 137 NVSYNriSSEGAKYLSKMK--------------------QlTYLDISHNKIGEDGskficngirqlthlniyyneigvrgvKFIGALKQLTSLNVGGNR 215
                 3333333444444444444....................144444444444222222111111111111122222443335566666666666666666 PP

                 EES-.SS-SEE-TT-S--EEES-EEESTT--SEE---TT---EEES-EEES CS
  Beta_helix  87 itdn.ggsGiylnyssnntienNiidnnagsGividdsssnvtvtnNtitn 136
                 i d   ++ +++++  ++ i+nN+i+  ++  ++ + + +n+++++N+i +
  EFC38901.1 216 IGDQgIEHLMRMHQLVDLNISNNNIRVEGAKLVSEMTQLTNLNIRKNIIGD 266
                 66663222446777899********99886776666666*********976 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0013
                 E-TT-S--EEES-EEESTT--SEE---TT---EEES-EEES-S...S CS
  Beta_helix  96 ylnyssnntienNiidnnagsGividdsssnvtvtnNtitnnk...g 139
                 +++y +n++i+ N+i++ ++  i  + + +n++ ++N it+ +    
  EFC38901.1 298 EMKYLTNLDIRSNNIREEGAEFIGEMKQLTNLNLNGNYITDEGikhL 344
                 34477888888888888887777777777888888888887665551 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (392 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       651  (0.0363099); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 2197.30
//
Query:       EFC38902.1  [L=297]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.5e-27   93.6   0.0    7.9e-26   90.6   0.0    2.1  1  Pep_deformylase  Polypeptide deformylase


Domain annotation for each model (and alignments):
>> Pep_deformylase  Polypeptide deformylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.6   0.0   4.4e-30   7.9e-26      21     158 ..      89     273 ..      72     274 .. 0.81

  Alignments for each domain:
  == domain 1  score: 90.6 bits;  conditional E-value: 4.4e-30
                      BSSHHHHHHHHHHHHHHHHHCT.................-SEEEGGGGT--BSEEE.............EECCSS-ETT....S.......... CS
  Pep_deformylase  21 kfeskelekllekmletmkeak.................gvgLAApQigvnkrlfv.............ielpseeeeeeenke.......... 74 
                      k+++++ + l +++ et+ e++                 g+g++ApQ   + r f+             +                        
       EFC38902.1  89 KLSDDDANYLYKQLSETLSENQimffrdlfmslkvyhddGTGISAPQLYHKIRYFIgtdrifkatpklkV-------------Vnakqsggfee 169
                      566666677777777777777677777777777777777*****************66655433333221.............23334566667 PP

                      ....................EEEEEEEEEEECSCEEECCEE--TTSTT--CEEEEESCEEEEEE-TTS-EEEEEEEHHHHHHHHHHHHHCTT-- CS
  Pep_deformylase  75 ....................ltvliNPkitskseetitdeEgClSvpgieakVeRskrikvkyldltgkeveleaegllArvlqHEiDhlnGkl 148
                                          l+++i Pki+ ks e++ + EgClS+++ +    Rsk+i+v+y+++ g +++ +++g+ Arv+qHE+Dhl+G+ 
       EFC38902.1 170 kknatseifdpdasyaydvdLELYIDPKIVDKSVEMEREVEGCLSFKNEYLFLMRSKEIEVEYINMFGVKQRKTLDGFSARVFQHEFDHLEGIN 263
                      7778999*************************************************************************************** PP

                      GGGGC-TTXX CS
  Pep_deformylase 149 fidridksek 158
                      ++dr+ +++k
       EFC38902.1 264 MFDRVVDKKK 273
                      ****998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (297 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       485  (0.0270511); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.37s 00:00:01.00 Elapsed: 00:00:00.56
# Mc/sec: 1599.05
//
Query:       EFC38903.1  [L=2453]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.3e-45  153.1   2.0    9.3e-45  153.1   2.0    3.0  4  UCH       Ubiquitin carboxyl-terminal hydrolase
    1.6e-17   64.1   0.2    1.6e-17   64.1   0.2    3.4  3  UCH_1     Ubiquitin carboxyl-terminal hydrolase
  ------ inclusion threshold ------
        6.1    7.1   9.3        7.3    6.8   0.1    3.6  4  DUF5106   Domain of unknown function (DUF5106)


Domain annotation for each model (and alignments):
>> UCH  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.9   4.1         3   1.8e+04     169     169 ..     272     272 ..      81     369 .. 0.60
   2 ?   -3.3   0.0      0.87   5.2e+03     177     208 ..    1038    1070 ..    1034    1083 .. 0.74
   3 ?   -3.5   0.1      0.95   5.7e+03      79     117 ..    1308    1346 ..    1136    1380 .. 0.58
   4 !  153.1   2.0   1.6e-48   9.3e-45       1     257 []    1631    1967 ..    1631    1967 .. 0.81

  Alignments for each domain:
  == domain 1  score: -5.9 bits;  conditional E-value: 3
                 E CS
                 x RF
         UCH 169 k 169
                 +
  EFC38903.1 272 E 272
                 2 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.87
                  B--SEEE-GGGBSS-BTTS-T.CS-BEEEEEEE CS
                  xxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxx RF
         UCH  177 efpeeldlssylaeekkkkte.ekkkYeLiavv 208 
                   +p++l++s y++e+  k+ + + k+YeL+ ++
  EFC38903.1 1038 GYPITLKISCYTNESFVKSVSsKMKIYELTNII 1070
                  689999999999998776655145679999876 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 0.95
                  HHHHHHHHHHSGGGTSSSTCEHHHHHHHHHHHHHHHHCC CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH   79 kklkktlsklaksfsgykqqDaqEflaflLdqlhedlnr 117 
                  k+  + l k+ ++f   + +  +E+l +lL++l   + +
  EFC38903.1 1308 KQCAALLLKILNKFIPENNERLNEILLNLLETLRVLIVE 1346
                  333444444444444555555666666666666655555 PP

  == domain 4  score: 153.1 bits;  conditional E-value: 1.6e-48
                  -EES-SSSTHHHHHHHHHHHTSHHHH.HHHHTCHHCCSSTCCCCC-.TT.TTS.TTHHHHHHHHHHHHHHSH-CCEE--HHHHHHHHHHSGGGTSSS CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         UCH    1 tGlsNlGntCymnsvlQcLfsipelr.dyllsleevkkesrnkkelnesnplgkkgelakalkdlfkellkskskavsPkklkktlsklaksfsgyk 96  
                  +Gl+N G+tCymns+lQ +f++ ++r ++++            +el ++++l+++  l+++++d+f+ l   ++k + ++ + ++ +   +  + ++
  EFC38903.1 1631 VGLKNQGATCYMNSLLQQFFMTIPFRkELITVN---------TDELPTNEKLQENVSLLREVQDMFAFLEYGRKKFYDTRPFCRVYKVDGRPVECST 1718
                  69************************5555552.........222222344455568*********999966899********************** PP

                  TCEHHHHHHHHHHHHHHHHCC...........................HCCCHHHHHHCCCTTSHHHHHH-EEEEE..................... CS
                  xxxxxxxxxxxxxxxxxxxxx...........................xxxxxxxxxxxxxxxxxxxxxxxxxxxx..................... RF
         UCH   97 qqDaqEflaflLdqlhedlnr...........................evaeekwkkhlkrndslitdlfegqlks..................... 145 
                  q+Da+Ef++  +d ++e+l+                            +                                                
  EFC38903.1 1719 QHDANEFFNLFMDCVEEALKFykkdyllrdvyggsllhqiiyeeniseR--------------------------Penfniislevknkrnimesle 1789
                  *******************997777777777777666666665555432..........................0333333333333444444455 PP

                  ...........................EEEEEEB-SEEEEEEESEEETEE...EEE--SEEB--SEEE-GGGBSS-BTTS-TCS-B........... CS
                  ...........................xxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........... RF
         UCH  146 ...........................klklkrlPeiLiihlkRfsynss...ksKlntkvefpeeldlssylaeekkkkteekkk........... 201 
                                             ++ +k lP++Li+hlkRf ++ s   ++K+n++vefp+ l++++y+ e+ ++k++++             
  EFC38903.1 1790 lycqgemlegnnqyfsdkldrhvdalkRTLIKDLPNVLILHLKRFDFDFSlmvNRKINDRVEFPHLLNMEPYTVEGMERKENRGIYdippphrpddy 1886
                  5555566669*************************************98899**********************9999987766559********** PP

                  ..EEEEEEEEEESCTTSEEEEEEEE..CTTTTEEEEEETTEEEEE-HH.................CCCTT.......CEEEEEE CS
                  ..xxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxx.................xxxxx.......xxxxxxx RF
         UCH  202 ..YeLiavvvHsGslssGHYvayik..nekngkWykydDetvkevkee.................eevls.......sayiLfY 257 
                    Y+L++v+vHsGs++sGHY+++i+  +++++kWy ++De++++ + +                 +   +       +ay+LfY
  EFC38903.1 1887 yqYKLVGVLVHSGSADSGHYYSFIMdrKNEEEKWYEFNDEEINPFDLNrmemecfgglvehnisgK---KtslfrcnNAYMLFY 1967
                  **********************99954556667************988888888888887666542...04567899******9 PP

>> UCH_1  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   3.5      0.28   1.7e+03      52     125 ..      85     300 ..      66     388 .. 0.50
   2 ?   -3.8   0.1       1.2   7.4e+03      56     156 ..    1441    1581 ..    1410    1606 .. 0.54
   3 !   64.1   0.2   2.7e-21   1.6e-17       1     320 []    1631    1928 ..    1631    1928 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.28
                 xxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxx.......................................xxxxxxxxxxx.... RF
       UCH_1  52 dmldkakglncqasnFlralssipe.....asalglileeeeete.......................................kssaislssli.... 102
                 d +d+ + +n   +n++++ + +++      ++ g+++eee+++e                                       +s+ ++l  li    
  EFC38903.1  85 DHEDENSENNFVDENLTNKTDDHQHdhlgsVQQNGIVKEEEDKKEekivkpdltpnpedlltfengfiekykkisdvykerlarHSNMQELLDLIdcei 183
                 455555667888888888888777433333566666655553322567777666666666666666666666666666666555333333333444443 PP

                 .............................................................................xxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1 103 .............................................................................qsfnrflldqlekelketkkns 124
                                                                                              + f++++ +q e+++++t+k+s
  EFC38903.1 184 kmldfirdqyatefdeynitnfksanaiwflqthmvsilnhttslhmiedndllskigdlinaairdyiyikitypfDLFQKIMESQAEQKSEKTEKSS 282
                 333333333333333333333333333333333333333333333333444444444444444444444444444433445555455444444444333 PP

                 .................x RF
       UCH_1 125 .................s 125
                                  +
  EFC38903.1 283 esleleesksssqlsekE 300
                 444444444444433322 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 1.2
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..........xxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxx.............. RF
       UCH_1   56 kakglncqasnFlralssipeasalglileeeeete..........kssaislssliqs....fnrflldqlekelketkkns.............. 124 
                   +++++  +s+F ++l +i   + + l++++ +  +          +  ++ ++++ q+    + + ++d+   e+++t+                 
  EFC38903.1 1441 LSSSSSQASSYFITTLYNIMMTEDIDLYKDRCD--DyflllensimN--SKHFTEISQEevftIVKKIFDRPIIEENNTSAADqvligyfniakali 1533
                  555556666777777777777777777633322..123555544331..222333333221122222233222222222222244555555555555 PP

                  .......xxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxx RF
       UCH_1  125 .......seeesaieqll.........gtkaettirclkCgseksrks 156 
                         +e ++ i++l+          t++++++   kC++++sr+ 
  EFC38903.1 1534 rtypflkQELHKHIKDLFlnglfevpkLTDQTDNLPLPKCKTKESRSA 1581
                  555555544444455555444445554455555555556666665555 PP

  == domain 3  score: 64.1 bits;  conditional E-value: 2.7e-21
                  xxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1    1 sGLEnhivnsYlNslLQvlyfipplr......nlalshlakeckkehcLlcElgflfdmldkakglncqasnFlralssipeasalglileeeeete 91  
                  +GL n+ +++Y+NslLQ ++++ p+r      n++   + ++ +++ +Ll E++ +f  l+ ++++   +  F+r  +       ++  ++++++  
  EFC38903.1 1631 VGLKNQGATCYMNSLLQQFFMTIPFRkelitvNTDELPTNEKLQENVSLLREVQDMFAFLEYGRKKFYDTRPFCRVYKVDG--RPVECSTQHDAN-- 1723
                  8*********************6666421114444555555677779*****************************99766..777776565433.. PP

                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1   92 kssaislssliqsfnrflldqlekelketkknsseeesaieqllgtkaettirclkCgseksrksstlvldlkyPkpsnekkeakvtfasilkssle 188 
                              +f + ++d++e+ lk  k     ++  + +++g ++ ++i     ++ ++r++++ +++l      ++k++   +++ + +  + 
  EFC38903.1 1724 ------------EFFNLFMDCVEEALKFYK-----KDYLLRDVYGGSLLHQIIYE--ENISERPENFNIISLEV----KNKRNIMESLELYCQGEML 1797
                  ............499999***999988765.....5899*************999..88889999999999944....3455555566666666665 PP

                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1  189 rekttrawCekCkryqpteqrktvknlPpvLalnakle.eeeelelwkt.......knwlpleiklsldedknleeklkeerekakaekeikvYeLq 277 
                  +  +++++ +k +r     +r  +k+lP+vL+l++k++  + +l++ ++       ++ l+ e ++ ++  + +e++   +  + + +++++ Y+L+
  EFC38903.1 1798 E-GNNQYFSDKLDRHVDALKRTLIKDLPNVLILHLKRFdFDFSLMVNRKindrvefPHLLNMEPYT-VEGMERKENRGIYDIPPPHRPDDYYQYKLV 1892
                  5.9*********************************986663333333366555545666655444.333333366677777778999********* PP

                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       UCH_1  278 svvvhigdskesghLvslvkvaekelerdppesqWylFNDflV 320 
                  +v vh g s +sgh++s++   +      ++e++Wy FND ++
  EFC38903.1 1893 GVLVHSG-SADSGHYYSFIMDRK------NEEEKWYEFNDEEI 1928
                  *******.555********9333......4568*******765 PP

>> DUF5106  Domain of unknown function (DUF5106)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.1    0.0012       7.3      39     111 ..     780     855 ..     770     859 .. 0.85
   2 ?   -2.6   0.0         1   6.1e+03      41      94 ..     940     999 ..     939    1012 .. 0.74
   3 ?    4.0   0.6    0.0091        54      75     129 ..    1980    2037 ..    1966    2044 .. 0.78
   4 ?   -3.6   0.1         2   1.2e+04     104     141 ..    2392    2429 ..    2362    2438 .. 0.61

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0012
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXX CS
     DUF5106  39 lveHYWDnfdfsDtllisneevteqafvdYlslls.qvpedsaeksvkkllskaek..sskaleyftelaekylyd 111
                 l++H++ nf+++  + ++n++ t+q+++d l++l+ ++    ++ svk+ +       ++ ++e+++++ e+y  d
  EFC38903.1 780 LMDHFFTNFEIQFPSDMENTSQTDQELRDQLDFLEfVIRNSPITLSVKNCIVLWTHgnRDIVMEWMAKMRENYCED 855
                 899******999888899*****************88888888899999888777777888899999999998765 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1
                 XXXXXXX.XXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....X CS
     DUF5106  41 eHYWDnf.dfsDtlli.sneevteqafvdYlsllsqvpedsaeksvkkllskaek....s 94 
                  H+W+ +  ++D  ++ +  e  ++    Y + l+++ +d  ek ++k ++ +++    s
  EFC38903.1 940 VHFWNLIlSVKDQKVLrQAIECLNNYKTGYAKELKHFIADYREKFIAKCMELLKQysspS 999
                 599998778999988845556666777789999999999999999999999888876443 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.0091
                  XXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
     DUF5106   75 vpedsaeksvkkllskaeksska....leyftelaekylydpnSplrneelYipvlekl 129 
                  ++e+sa++ +++++++++k+++      + f e +++yl+ + S +++ + Y +vl+++
  EFC38903.1 1980 TKETSAIQPASSVMTQVWKENEKfyhyKNIFDESFDSYLFGNLSTYQSND-YAMVLRNV 2037
                  6788999************55542332456889999**********9977.77777765 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 2
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
     DUF5106  104 laekylydpnSplrneelYipvlekllkspkvdeaeke 141 
                  ++ + ++d  S + + +  +  +++l+k ++++ + k+
  EFC38903.1 2392 FCLDQYFDSLSRMTDNNSLLYCMKHLAKIDRMNAYTKS 2429
                  44444555555555555555555555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2453 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1536  (0.0856713); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.35u 0.31s 00:00:01.66 Elapsed: 00:00:00.55
# Mc/sec: 13349.28
//
Query:       EFC38904.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
       0.58   10.1   4.5          1    9.3   4.5    1.3  1  INO80_Ies4  INO80 complex subunit Ies4
        2.3    8.9   5.8       0.43   11.2   0.2    2.8  4  Ipi1_N      Rix1 complex component involved in 60S ribosome m


Domain annotation for each model (and alignments):
>> INO80_Ies4  INO80 complex subunit Ies4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   4.5   0.00011         1      26      94 ..     252     333 ..     242     342 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00011
  INO80_Ies4  26 ivtlkvspekLraile....d.........kekekkeekespasssaapaakaeskadnasdsnsatPa..egtPapssaamgp 94 
                 i ++++s+++L++ ++    d         ++ +++++ ++p +ssa+++++++++++ a++s+++tP   ++ P++s+   +p
  EFC38904.1 252 IEVFRLSSKELSQSIPtlleDvkpriintmTQPAANTNITTPVDSSATSSSQSNATTNYATESTATTPIaqDDNPTTST--EAP 333
                 5567888888888777455425555555554455556666666666666666666678888888888874444555444..443 PP

>> Ipi1_N  Rix1 complex component involved in 60S ribosome maturation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       1.6   1.4e+04      79      98 ..      32      51 ..      21      55 .. 0.59
   2 ?   11.2   0.2   4.8e-05      0.43      18      75 ..      87     166 ..      71     197 .. 0.74
   3 ?   -1.4   0.0      0.39   3.5e+03      48      62 ..     208     227 ..     187     265 .. 0.64
   4 ?   -1.7   0.2       0.5   4.5e+03      30      30 ..     299     299 ..     276     322 .. 0.53

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.6
      Ipi1_N 79 ssssskktskksrlkvLsvl 98
                ss+++ k+++k+    Ls l
  EFC38904.1 32 SSQNVIKLDNKWINAWLSIL 51
                45555555555555555544 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 4.8e-05
      Ipi1_N  18 mTHispdIredslkfLdllLevapeelvssawv........................ktLnnflallgwskeksskgstsak 75 
                 ++H++ dIr+ +l++L+  L ++ +   + ++                          +L++f++ l   k k+++ +t+ +
  EFC38904.1  87 LSHLQRDIRTQALSTLQRSLVYSCDF--RYSFTanqedsqnlkyllndqllmmcmdrVLLKTFFQTLLTLKPKTTEYQTNHN 166
                 79****************99998888..333445566666666667777777888888889999888887766666666643 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.39
      Ipi1_N  48 a.....wvktLnnflallgw 62 
                 +     w+ +L+ + + l +
  EFC38904.1 208 NgfsslWLTILQVMYNFLLV 227
                 23333477666666655544 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.5
      Ipi1_N  30 l 30 
                 +
  EFC38904.1 299 T 299
                 1 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       965  (0.0538234); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.43
# Mc/sec: 2382.68
//
Query:       EFC38905.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.15   11.7   2.3       0.26   11.0   2.3    1.3  1  Methyltrn_RNA_2  Putative SAM-dependent RNA methyltransferase
        0.2   10.9   6.1       0.35   10.2   6.2    1.3  1  YPEB             YpeB sporulation
       0.65    9.5   4.5        8.5    5.9   3.0    2.1  2  RSRP             Arginine/Serine-Rich protein 1
        5.3    7.1   8.0         12    6.0   8.0    1.6  1  MAS20            MAS20 protein import receptor


Domain annotation for each model (and alignments):
>> Methyltrn_RNA_2  Putative SAM-dependent RNA methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   2.3   5.7e-05      0.26      70     127 ..     219     277 ..     214     289 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 5.7e-05
                      TTT--S--SSHHHHHHHHHHHHCHCC.TGCCSEEEEETTEEEE---HHHHHHHHHCTSE CS
  Methyltrn_RNA_2  70 asevkkvspderniailikkalkave.eikkqekkvrpgltVrkegfealleelsekks 127
                       +e k+ s+   +ia+ +k++lk+++  + ++e + ++ + +++ g e+l+++ +e++ 
       EFC38905.1 219 SKETKDTSKKSSSIAMSLKNLLKKKKkDGTQNEVEKKAQIFIKHVGYEELVKKSKEQHK 277
                      567788999999***********9994444555567889*************9999864 PP

>> YPEB  YpeB sporulation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   6.2   7.9e-05      0.35     214     312 ..     181     278 ..     126     290 .. 0.71

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 7.9e-05
        YPEB 214 kiakkflgkkkaekvevvesekkgkipaYsvevkdkkakkeeitvdvskkGGhviwllneRevgepk.isleeaaekAkefLeklGyknmeptyseeyd 311
                 +++  +++  + e  +v+es+k++k  +  ++ k++k+ k   t d skk+  + + l++   +++k  +++e ++kA+ f++  Gy+++++ + e+++
  EFC38905.1 181 DVIPCIIDSMDVEPTNVEESNKEEKKGFSLFKSKESKESK--ETKDTSKKSSSIAMSLKNLLKKKKKdGTQNEVEKKAQIFIKHVGYEELVKKSKEQHK 277
                 5555566666666677777766555544445555555444..599**********9999976555543899*******************999988876 PP

        YPEB 312 n 312
                 +
  EFC38905.1 278 E 278
                 5 PP

>> RSRP  Arginine/Serine-Rich protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.013        58     179     264 ..      70     166 ..      59     180 .. 0.54
   2 ?    5.9   3.0    0.0019       8.5     217     273 ..     199     255 ..     186     275 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.013
        RSRP 179 eiakanaakalGvanldlP..aslrevevakeasrg....avsssgdkee...rv.rvdlseqkteddeaeaaeks....karkqivfssnnavakpli 263
                  + k na  +lG++ +dl   +sl  +e  +++ r     ++  +++ +e    + + d+ +qk +dd+ ++ e +    ++ k+++++ +  v+ +li
  EFC38905.1  70 VVDKINAPAILGIKRVDLQvtESLV-MES-RDKCRVicdiCLVGESPMKEffeISaIFDF-AQKSNDDNFQSVELTidmkAEFKKLIWTVTDFVENALI 165
                 5789**********99986226665.333.333332111222233333331113313333.34444444443332212214456677777777777666 PP

        RSRP 264 k 264
                 k
  EFC38905.1 166 K 166
                 6 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0019
        RSRP 217 sgdkeervrvdlseqkteddeaeaaekskarkqivfssnnavakpliktikalveed 273
                 +++kee+    l + k  ++++e+ ++sk+   i++s +n+++k  ++ ++  ve++
  EFC38905.1 199 ESNKEEKKGFSLFKSKESKESKETKDTSKKSSSIAMSLKNLLKKKKKDGTQNEVEKK 255
                 57788888888888888999***********************99777777666654 PP

>> MAS20  MAS20 protein import receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   8.0    0.0027        12      32      89 ..     214     274 ..     198     286 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0027
       MAS20  32 rrkkqakaakeeeeaekaekkk.kealeeakee.lptdaeevekfFleevqlGEellaq.g 89 
                 ++ k++k++k++++++++ + + k++l+++k++  +++ e++ ++F+++v   E + ++ +
  EFC38905.1 214 KESKESKETKDTSKKSSSIAMSlKNLLKKKKKDgTQNEVEKKAQIFIKHVGYEELVKKSkE 274
                 333333333333333333334488888999988999**************98555444432 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2579  (0.143845); expected 358.6 (0.02)
Passed bias filter:                      681  (0.0379832); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 1916.04
//
Query:       EFC38906.1  [L=464]
Description: hypothetical protein NAEGRDRAFT_44774 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.2e-63  213.5   0.0    4.6e-63  213.0   0.0    1.2  1  Tubulin          Tubulin/FtsZ family, GTPase domain
    1.1e-24   87.0   0.1    2.3e-24   86.0   0.0    1.6  2  Tubulin_C        Tubulin C-terminal domain
      0.001   18.3   0.0     0.0016   17.7   0.0    1.3  1  Tubulin_2        Tubulin like
     0.0035   17.6   0.1      0.054   13.8   0.0    2.5  2  Misat_Tub_SegII  Misato Segment II tubulin-like domain
  ------ inclusion threshold ------
      0.018   14.7   0.0      0.033   13.9   0.0    1.4  1  Tubulin_3        Tubulin domain
       0.13   12.2   1.4       0.47   10.4   0.0    2.2  2  TnpV             Transposon-encoded protein TnpV


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  213.0   0.0   1.5e-66   4.6e-63       1     197 []       4     222 ..       4     222 .. 0.91

  Alignments for each domain:
  == domain 1  score: 213.0 bits;  conditional E-value: 1.5e-66
                 EEEEEEEHHHHHHHHHHHHH...HHHCH..............HHHT.....................TTEEEEE....EEESBHHHHHTS-GS...... CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiq.sdg.........dslesfFse................sgkveyiprsvaidtdpqvlneikags..elf 71 
                 ei++i+vGqcGnqig ++w+l+++eh++  +++         d       e                 g  ++ +r++++d+++ v+n+i ++    lf
  EFC38906.1   4 EIVTIQVGQCGNQIGGRMWDLVLREHAAVfQNKknqnpdilyD-------EplstffkwdmeqksrrAGMPDIKARALLVDMEEGVVNQIFKSDigGLF 95 
                 79*************************9876668955555551.......455555556999998887777888**********************9** PP

                 ..EEEE-.-CCCCTTC--TT-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--GG.G-HHHHHH CS
     Tubulin  72 npnklll.gkegagnngaggypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPsefsevvvepyn 169
                 n++++++ + +g+gnn+a+g++ +g +++eeile+ir eve+cds+q+ff+++slgGGTGSGlg++i++vl +e+p++ +++ +v+Ps++++v+++pyn
  EFC38906.1  96 NRDRQVIsDVSGSGNNWAHGHEVYGPKYHEEILEKIRWEVEECDSIQSFFLLHSLGGGTGSGLGSFITQVLHDEFPDIYTFSACVFPSKDDDVITSPYN 194
                 987665506677*************************************************************************************** PP

                 HHHHHHHHHHT-SEEEEEEHHHHHCCST CS
     Tubulin 170 ailalkelieesdavividNdaLlkiln 197
                 ++l+l+el+e+sd+v++i+N+aL+++++
  EFC38906.1 195 SLLSLNELSENSDCVLPIENQALYDMCK 222
                 *************************996 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       4.1   1.2e+04     102     116 ..     248     262 ..     238     264 .. 0.72
   2 !   86.0   0.0   7.6e-28   2.3e-24       1     125 [.     285     405 ..     285     406 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.1
                 TTSSCEEEEEEEEGG CS
   Tubulin_C 102 kqskvsvlmlaNtts 116
                 ++++ ++++l N ts
  EFC38906.1 248 QMNDIAATLLTNLTS 262
                 344589999999997 PP

  == domain 2  score: 86.0 bits;  conditional E-value: 7.6e-28
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEE.SSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEECEC CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirG.dvepkevnkavqrikekkkaqfveWiptgikvalnkksp 98 
                 Prl Fll+s++P+v +++ +  +++++++++++l+ + ++ k+dp ++kyl++ l++rG + +++++n++++++k ++   +++W+++g+kv+l++++p
  EFC38906.1 285 PRLKFLLSSLSPFVMPKDVHLPPRRMDQMFKDVLSRDYQLLKCDPIHHKYLSCGLILRGqQANISDINRNIAKMKGEMD--MIYWNQEGFKVGLCHVAP 381
                 9**********************************************************7799***********99988..****************** PP

                 T-TTTSSCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C  99 yvkkqskvsvlmlaNttsiaelfkrll 125
                 + ++ s    l laN+++i ++f++++
  EFC38906.1 382 HNQPYS---LLCLANNCCIGNVFSDMH 405
                 ***999...**************9875 PP

>> Tubulin_2  Tubulin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   5.2e-07    0.0016     133     227 ..     125     210 ..      67     285 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 5.2e-07
   Tubulin_2 133 eeirealrdaikrlrgsageeeglnvfVvgSLaGGTGSGiflDvayllrkilkeekqkvkiiglvllPdvfplnkeggervkaNayaaLkELna..... 226
                 eei+e++r  ++++ +         +f++ SL GGTGSG+   ++ +l++++++      ++++v  P+     +++      N++ +L+EL+      
  EFC38906.1 125 EEILEKIRWEVEECDS------IQSFFLLHSLGGGTGSGLGSFITQVLHDEFPDIYT---FSACV-FPSK----DDDVITSPYNSLLSLNELSEnsdcv 209
                 5677777777777777......468****************************9997...45554.4554....4556777788888888888844444 PP

   Tubulin_2 227 l 227
                 l
  EFC38906.1 210 L 210
                 3 PP

>> Misat_Tub_SegII  Misato Segment II tubulin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   1.8e-05     0.054       1      44 [.       3      45 ..       3      91 .. 0.65
   2 ?    0.6   0.1      0.22   6.5e+02      42      86 ..     410     454 ..     400     459 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 1.8e-05
  Misat_Tub_SegII  1 rEivtlqlGnyaNyvgtHfWNt..Qe..syftydeeeeesevdhdvlf 44
                     rEivt+q+G+  N +g   W +  +e  ++f+ ++++++     d+l+
       EFC38906.1  3 REIVTIQVGQCGNQIGGRMWDLvlREhaAVFQNKKNQNP-----DILY 45
                     8*******************9633441134444444443.....3333 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.22
  Misat_Tub_SegII  42 vlfregetkqgqvtytPRllivDlkgslgslrkegelyeekeeee 86 
                       l+++++ +++ ++y+P +l  ++ ++  sl +e ++ ++k+eee
       EFC38906.1 410 KLYKKKIYTHHYTEYMPEALFDEALENAASLIEEYASLQNKTEEE 454
                      4677777789999999*9999999999999998888887554443 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   1.1e-05     0.033      42     155 ..     111     215 ..      98     240 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.1e-05
   Tubulin_3  42 dwsvGeeLfeeldkehdlldrdlrpfaeecdqlrglqvftgvddaWG.GfaakylerlrdeygkksilvWvlaleeklkkkkkaklerklkklnkarsl 139
                 +w+ G+e++      h+ +   +r  +eecd+++++ ++ +     G G ++   + l+de++   i+++   +  ++k++        ++  n+  sl
  EFC38906.1 111 NWAHGHEVYGPK--YHEEILEKIRWEVEECDSIQSFFLLHSLGGGTGsGLGSFITQVLHDEFPD--IYTFSACV-FPSKDDDV-----ITSPYNSLLSL 199
                 677777777653..34434456999*****************9988846777777889*****9..44554333.33333222.....34567999999 PP

   Tubulin_3 140 kelseqaslyvPiakl 155
                 +else++  ++Pi + 
  EFC38906.1 200 NELSENSDCVLPIENQ 215
                 9999999999999753 PP

>> TnpV  Transposon-encoded protein TnpV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   0.00016      0.47      43     101 ..     193     254 ..     189     257 .. 0.86
   2 ?   -0.5   0.4      0.38   1.1e+03      31      76 ..     412     446 ..     399     457 .. 0.41

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00016
        TnpV  43 YtelllsgkLneh...laeideqaeerlerlvkqlaekegvteelkakdqmewvqrmnnirn 101
                 Y++ll  ++L e    +  i++qa   + + v++l +k++vt +l +++  + + +mn i +
  EFC38906.1 193 YNSLLSLNELSENsdcVLPIENQALYDMCKFVNSLEKKKDVTSTLSKEEDSKPFDQMNDIAA 254
                 88888888887753336789****************************99********9987 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.38
        TnpV  31 rleyLkehkkvlYt.elllsgkLnehlaeideqaeerlerlvkqlae 76 
                 +++ + +h+  +Y  e l             ++a e    l++++a+
  EFC38906.1 412 YKKKIYTHHYTEYMpEALF------------DEALENAASLIEEYAS 446
                 2223333333333212223............3333333344444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       586  (0.0326845); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2906.61
//
Query:       EFC38907.1  [L=561]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-10   39.4  43.0      0.024   15.1   3.3   10.0 11  LRR_4     Leucine Rich repeats (2 copies)
    5.6e-05   22.9  20.1       0.34   11.1   0.0    9.5 11  LRR_6     Leucine Rich repeat
     0.0024   17.6  25.4      0.017   14.8   0.7    7.9  7  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.3      0.04   2.4e+02       8      33 ..     125     145 ..     124     153 .. 0.79
   2 ?    2.8   0.3     0.029   1.7e+02      18      32 ..     155     169 ..     137     180 .. 0.65
   3 ?    4.2   0.1     0.011        64      21      37 ..     213     228 ..     191     234 .. 0.77
   4 !   11.6   0.1   4.9e-05      0.29       2      39 ..     238     276 ..     237     283 .. 0.81
   5 !    7.8   3.0   0.00079       4.7       1      33 [.     264     304 ..     264     316 .. 0.73
   6 !    8.5   1.3   0.00046       2.7       3      39 ..     296     336 ..     294     340 .. 0.77
   7 !    8.3   0.1   0.00054       3.2       3      39 ..     349     384 ..     347     399 .. 0.80
   8 !   15.1   3.3     4e-06     0.024       2      36 ..     404     439 ..     403     443 .. 0.88
   9 ?    1.2   0.0     0.093   5.5e+02       3      39 ..     454     492 ..     452     502 .. 0.74
  10 !    6.3   0.1    0.0023        14      19      37 ..     501     519 ..     489     525 .. 0.77
  11 !    7.7   0.4   0.00082       4.9       1      36 [.     505     544 ..     505     547 .. 0.66

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.04
                 --SS---E-S-HHH-TT--EEE-.-S CS
       LRR_4   8 LsnNqltdiplleklpnLkeLdLsgN 33 
                 +++N+  +++    +++L+ L L  N
  EFC38907.1 125 FNSNMCESLSH---CKSLRFLKL--N 145
                 56788888778...********9..3 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.029
                 -HHH-TT--EEE-.- CS
       LRR_4  18 lleklpnLkeLdLsg 32 
                 l++ lp+L+ L++s 
  EFC38907.1 155 LFNTLPKLRFLYVST 169
                 3677*******9954 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.011
                 H-TT--EEE-.-S---- CS
       LRR_4  21 klpnLkeLdLsgNnlit 37 
                 k+p+L  L+L +N +it
  EFC38907.1 213 KFPKLVILYL-ENQNIT 228
                 6999999999.665565 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 4.9e-05
                 S--EEE--SS.---E-S-..HH..H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnN.qltdipl..le..klpnLkeLdLsgNnlitdl 39 
                 n ++L++  + +ltd++   l+  ++pnL++L Ls +    ++
  EFC38907.1 238 NCKELCFDKCyKLTDVGAnaLSktNCPNLETLKLSAC----SI 276
                 6778888888899**9998855778*********998....44 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.00079
                 SS--EEE--SS---E-S-.....HH..H.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl.....le..k.lpnLkeLdLsgN 33 
                 pnLe+L Ls + +++ +l     ++  + l +Lk+L +s N
  EFC38907.1 264 PNLETLKLSACSIRSQGLkslfhPNnaQlLNQLKYLEMSKN 304
                 8********88988777766544559986777******999 PP

  == domain 6  score: 8.5 bits;  conditional E-value: 0.00046
                 --EEE--SS-.....--E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNq.....ltdiplleklpnLkeLdLsgNnlitdl 39 
                 L++L  s N      l+ + +++ ++nL+++d + +++++d+
  EFC38907.1 296 LKYLEMSKNLmvgtaLQNLKNFQ-FDNLETVDFNYCSNLSDV 336
                 89999998755555577777777.********9888888886 PP

  == domain 7  score: 8.3 bits;  conditional E-value: 0.00054
                 --EEE--SS---E-S-....HHH-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdipl....leklpnLkeLdLsgNnlitdl 39 
                  ++L L+++ +t +++    le++ +L++L L +N     +
  EFC38907.1 349 VKILKLNQCGIT-FDGfsyiLENCSKLHKLQLVSN----AI 384
                 5899********.6674566669*********888....44 PP

  == domain 8  score: 15.1 bits;  conditional E-value: 4e-06
                 S--EEE--SS---E-S-.HHH-TT.--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpn.LkeLdLsgNnli 36 
                 nL+ + L +N++t i++ le lp+ L  L+Ls N +i
  EFC38907.1 404 NLKLIKLEDNKITNIDWlLEHLPKkLDFLNLSAN-PI 439
                 99999************77789999******999.66 PP

  == domain 9  score: 1.2 bits;  conditional E-value: 0.093
                 --EEE--SS---E-S-HH......H-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdiplle......klpnLkeLdLsgNnlitdl 39 
                  ++L L  ++ltd   le      ++p L+ + + gN    d+
  EFC38907.1 454 ITYLTLEKCNLTDEFILEtklsqeQIPCLQAFRVIGN----DF 492
                 6889999999999666666666766888887777677....54 PP

  == domain 10  score: 6.3 bits;  conditional E-value: 0.0023
                 HHH-TT--EEE-.-S---- CS
       LRR_4  19 leklpnLkeLdLsgNnlit 37 
                 +e+ p+L+ L LsgN ++t
  EFC38907.1 501 IEQQPQLTRLFLSGNARLT 519
                 4568999999999997775 PP

  == domain 11  score: 7.7 bits;  conditional E-value: 0.00082
                 SS--EEE--SS.---E-S-...HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnN.qltdipl...lek.lpnLkeLdLsgNnli 36 
                 p+L+ L Ls+N +lt       + +    L++L+L  ++li
  EFC38907.1 505 PQLTRLFLSGNaRLTN-KTidtIVNsKLELQVLWLEKCPLI 544
                 789******8868883.232223332455999999888666 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.53   3.1e+03      15      24 .]     250     259 ..     249     259 .. 0.84
   2 !   11.1   0.0   5.7e-05      0.34       1      23 [.     262     284 ..     262     285 .. 0.95
   3 ?    0.3   0.0      0.16   9.6e+02       4      14 ..     295     305 ..     293     310 .. 0.82
   4 !    6.9   0.0    0.0012       7.4       4      23 ..     321     341 ..     321     342 .. 0.93
   5 ?    0.4   0.0      0.15   9.1e+02       2      16 ..     346     360 ..     346     366 .. 0.87
   6 ?    3.8   0.3     0.012        72       1      16 [.     370     385 ..     370     385 .. 0.93
   7 ?   -2.2   0.2         1   6.2e+03       5      17 ..     405     417 ..     404     417 .. 0.74
   8 ?    0.6   0.0      0.13   8.1e+02       8      17 ..     432     441 ..     427     442 .. 0.85
   9 ?    2.2   0.0      0.04   2.4e+02       5      18 ..     454     467 ..     450     467 .. 0.87
  10 ?   -0.1   0.0      0.23   1.3e+03      11      23 ..     488     500 ..     480     500 .. 0.74
  11 ?   -1.1   0.0      0.47   2.8e+03       4      17 ..     506     520 ..     504     521 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.53
       LRR_6  15 IgDeGaeaLa 24 
                 ++D+Ga aL+
  EFC38907.1 250 LTDVGANALS 259
                 89****9986 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 5.7e-05
       LRR_6   1 snthLteLdLsgNdIgDeGaeaL 23 
                 ++++L++L Ls + I  +G+++L
  EFC38907.1 262 NCPNLETLKLSACSIRSQGLKSL 284
                 699******************99 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.16
       LRR_6   4 hLteLdLsgNd 14 
                  L++L++s N 
  EFC38907.1 295 QLKYLEMSKNL 305
                 69******996 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0012
       LRR_6   4 hLteLdLsgNd.IgDeGaeaL 23 
                 +L+++d +++  ++D+G++ L
  EFC38907.1 321 NLETVDFNYCSnLSDVGVKTL 341
                 699***************988 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.15
       LRR_6   2 nthLteLdLsgNdIg 16 
                 + +++ L L+ ++I+
  EFC38907.1 346 CKTVKILKLNQCGIT 360
                 6799*********98 PP

  == domain 6  score: 3.8 bits;  conditional E-value: 0.012
       LRR_6   1 snthLteLdLsgNdIg 16 
                 ++++L +L+L +N I+
  EFC38907.1 370 NCSKLHKLQLVSNAIT 385
                 699**********997 PP

  == domain 7  score: -2.2 bits;  conditional E-value: 1
       LRR_6   5 LteLdLsgNdIgD 17 
                 L+   L +N+I++
  EFC38907.1 405 LKLIKLEDNKITN 417
                 55567899***96 PP

  == domain 8  score: 0.6 bits;  conditional E-value: 0.13
       LRR_6   8 LdLsgNdIgD 17 
                 L+Ls N Ig+
  EFC38907.1 432 LNLSANPIGN 441
                 9*******98 PP

  == domain 9  score: 2.2 bits;  conditional E-value: 0.04
       LRR_6   5 LteLdLsgNdIgDe 18 
                 +t+L L  ++++De
  EFC38907.1 454 ITYLTLEKCNLTDE 467
                 79***********8 PP

  == domain 10  score: -0.1 bits;  conditional E-value: 0.23
       LRR_6  11 sgNdIgDeGaeaL 23 
                  gNd++D+ +++L
  EFC38907.1 488 IGNDFTDDAIQKL 500
                 58*****988876 PP

  == domain 11  score: -1.1 bits;  conditional E-value: 0.47
       LRR_6   4 hLteLdLsgNd.IgD 17 
                  Lt L LsgN  +++
  EFC38907.1 506 QLTRLFLSGNArLTN 520
                 599999****87776 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.4     0.034   2.1e+02      23      56 ..     135     167 ..     131     169 .. 0.50
   2 ?    0.1   0.0      0.12   7.1e+02       1      14 [.     215     228 ..     211     231 .. 0.57
   3 !    4.4   2.0    0.0054        32      23      60 ..     262     305 ..     247     306 .. 0.66
   4 ?    2.3   2.6     0.023   1.4e+02      40      59 ..     285     304 ..     264     319 .. 0.56
   5 ?    2.4   0.0     0.022   1.3e+02      24      38 ..     371     385 ..     347     390 .. 0.68
   6 !   14.8   0.7   2.9e-06     0.017      25      61 .]     403     439 ..     399     439 .. 0.84
   7 ?    2.7   0.0     0.018   1.1e+02      25      35 ..     505     515 ..     489     542 .. 0.73

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.034
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 ++++L+ L+L+    t++ +  f  Lp+Lr+L++
  EFC38907.1 135 HCKSLRFLKLNTVYDTSF-KILFNTLPKLRFLYV 167
                 444444444444333333.455666777777766 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.12
                 TT-SEEE-TTS--S CS
       LRR_8   1 pnLtsLdLsnNrlt 14 
                 p+L +L+L n ++t
  EFC38907.1 215 PKLVILYLENQNIT 228
                 34555555555554 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.0054
                 T-TT--EEE--SS--......-GGGGGGGTT--S-.EEE--SS- CS
       LRR_8  23 glsnLkvLdLsnNll......ttlspgafsgLpsLrsLdLsgNr 60 
                 +++nL++L+Ls  ++      + ++p+  + L++L++L +s N 
  EFC38907.1 262 NCPNLETLKLSACSIrsqglkSLFHPNNAQLLNQLKYLEMSKNL 305
                 57888888887655511111145677777778888888888875 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.023
                 GGGGGGTT--S-.EEE--SS CS
       LRR_8  40 lspgafsgLpsLrsLdLsgN 59 
                 ++p+  + L++L++L +s N
  EFC38907.1 285 FHPNNAQLLNQLKYLEMSKN 304
                 44444444555555555544 PP

  == domain 5  score: 2.4 bits;  conditional E-value: 0.022
                 -TT--EEE--SS--- CS
       LRR_8  24 lsnLkvLdLsnNllt 38 
                 +s+L  L+L +N +t
  EFC38907.1 371 CSKLHKLQLVSNAIT 385
                 555555555555554 PP

  == domain 6  score: 14.8 bits;  conditional E-value: 2.9e-06
                 TT--EEE--SS---GGGGGGGTT--.S-.EEE--SS-- CS
       LRR_8  25 snLkvLdLsnNllttlspgafsgLp.sLrsLdLsgNrL 61 
                 +nLk ++L +N++t ++   +++Lp +L++L+Ls N++
  EFC38907.1 403 ENLKLIKLEDNKITNID-WLLEHLPkKLDFLNLSANPI 439
                 79**************8.555666528*********87 PP

  == domain 7  score: 2.7 bits;  conditional E-value: 0.018
                 TT--EEE--SS CS
       LRR_8  25 snLkvLdLsnN 35 
                 ++L+ L Ls N
  EFC38907.1 505 PQLTRLFLSGN 515
                 55555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (561 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       556  (0.0310112); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 3479.81
//
Query:       EFC38908.1  [L=665]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-19   69.1   0.1    8.5e-19   68.1   0.1    1.5  1  CLP1_P    mRNA cleavage and polyadenylation factor CLP1 P-loo
  ------ inclusion threshold ------
        5.3    6.8  11.7         10    5.9  11.7    1.4  1  Pox_Ag35  Pox virus Ag35 surface protein


Domain annotation for each model (and alignments):
>> CLP1_P  mRNA cleavage and polyadenylation factor CLP1 P-loop
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.1   0.1   9.5e-23   8.5e-19       1     131 [.     215     341 ..     215     376 .. 0.89

  Alignments for each domain:
  == domain 1  score: 68.1 bits;  conditional E-value: 9.5e-23
      CLP1_P   1 GpkdsGKSTlarlLlNyalrkgrkpvyvDlDvGqseispPgtislalverpidveegfsldaplv..yffGdtspsdnpslylalvkelareveeklee 97 
                 G+  sGKS ++ +L+N++l+ + k+++++l+++ + +++ gt+sl+++++p  ++ + +++++l    ++G+++ + +++ yl++  el++ +      
  EFC38908.1 215 GHALSGKSLFSNYLMNELLNYYPKVAFLNLNINVPTFGIRGTLSLSIHSNPTFGPLFQNTKNELIyqIYHGHSTTDIQIETYLKQSLELYQIYC----- 308
                 7788*****************************************************9999999622578************************..... PP

      CLP1_P  98 nkkakasgliIntpGwvkglgaellleliealep 131
                  kk+ + +liIn++++  + g++++lel+++l+ 
  EFC38908.1 309 -KKYSNIPLIINSQSLLPSSGYQIILELLQILNQ 341
                 .566779************************997 PP

>> Pox_Ag35  Pox virus Ag35 surface protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  11.7    0.0011        10      76     146 ..      13      80 ..       2      94 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0011
    Pox_Ag35  76 keeaaeeeeledseedeenendedeseesvqaeeeksnesteddadeldeSdLkvatenIikdlkkltarv 146
                 ++ + +eee+++++ d+++e+d+d+ +e ++++ee+ +e + d+++++ +S++k   + I  +lk+l++ +
  EFC38908.1  13 SDDEINEEEINQENSDDQQEEDNDDANELMNQQEEDIDEMNDDEKESSLNSEMK---NSIEIKLKNLNSTI 80 
                 344555666777777777777777777777777777888877888888888887...55666777777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2298  (0.128172); expected 358.6 (0.02)
Passed bias filter:                      641  (0.0357521); expected 358.6 (0.02)
Passed Vit filter:                        94  (0.0052429); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.81u 0.30s 00:00:01.11 Elapsed: 00:00:00.48
# Mc/sec: 4182.69
//
Query:       EFC38909.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.42    9.2  46.7        0.7    8.5  46.7    1.3  1  Hamartin         Hamartin protein


Domain annotation for each model (and alignments):
>> Hamartin  Hamartin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  46.7   3.9e-05       0.7     279     583 ..      41     378 ..       5     392 .. 0.56

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 3.9e-05
    Hamartin 279 spytdlqsstgsststpistkr..............lqlsslsgtspavlsvessrskddei.......................slWSPssvcgmttp 340
                 sp t++               +               ql    + +++++s+++++++ +++                        ++ P ++ g  t+
  EFC38909.1  41 SPNTNA---------------NntaintivnpftlpSQLIGNVHHHQQQQSPPQQQQHMIQSsihvipynnisttasvpvitnqsIVFPPPLLQGTQTT 124
                 222222...............222223333333333122222222222222222222222223455677666666666666666566677789999999 PP

    Hamartin 341 psspgivpttelelsssasllsskvsstpeaagkatpe...tTPakssrklppslsesavvvalpassrksspprkdeksesskpdlskqeevenekel 436
                  s+p+++ t +++  +++ +  s+ ss++ +  + t +   + P+      ++++s+s+ + + ++s ++ssp +k++ks++  +++++  + +++++ 
  EFC38909.1 125 ASHPTSSSTMTHQHVYESNNRLSSLSSPSDEDEEMTEQlniAEPLVN----QSTNSSSTGS-SSSHSNNTSSPESKKRKSTRRTSNTRRRSHSNQSNHS 218
                 98888887766777777777777888888874444444333444443....3444444444.3333344699999999999999999**9999999999 PP

    Hamartin 437 eeslkskssvtlseLsdvikel............leaesedsvekeeeeaaisqelseiteekket.lvsrggldspfsrtleslaksqr..rkrlasa 520
                 ++++   ss +++eL+ +++++             + + + + e+e + + i +  ++i++ +  + l + + l+  + +++ s +++    rk++ s+
  EFC38909.1 219 NDQTVASSSSNTQELNAFVHQTtcciqnctkdvsNRLRFSLRCETEFKPDYIAKFWNNICNYCYFHdLYQWKKLNQQTDSNTSSATSTSTtkRKNTSST 317
                 999999**************9988866655443333333333478888888888888888888544555555555554444444444333224555555 PP

    Hamartin 521 lssesisdaegaatkkeaksskeaesslekekscsakqsftpieqklesskdcpadeeesens 583
                 +ss + ++ ++ +t++  ++s+++++s+++e+++++++  + ++q+  s  ++++++ ++ ++
  EFC38909.1 318 SSSGRKRANSSLSTNS--TTSTRSSKSVKSEHQDQISHHHQDHQQEYLSPPSSSNNNTTTATT 378
                 5555333333333333..466677777777777777777766666666544333333332222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2784  (0.155279); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                       160  (0.00892409); expected 17.9 (0.001)
Passed Fwd filter:                        67  (0.00373696); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.28u 0.35s 00:00:01.63 Elapsed: 00:00:00.54
# Mc/sec: 2191.77
//
Query:       EFC38910.1  [L=540]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.5e-06   26.6   1.6    7.5e-06   26.6   1.6    2.1  2  Torus      Torus domain
    0.00031   20.7   0.4    0.00096   19.1   0.4    1.8  1  Med26      TFIIS helical bundle-like domain
    0.00048   20.1   4.9    0.00088   19.2   4.9    1.5  1  zf_CCCH_4  Zinc finger domain
      0.001   18.8   3.1     0.0018   18.0   3.1    1.3  1  zf-CCCH_4  CCCH-type zinc finger
     0.0055   16.6   2.9       0.01   15.7   2.9    1.5  1  zf-CCCH    Zinc finger C-x8-C-x5-C-x3-H type (and similar)
  ------ inclusion threshold ------
      0.012   16.0   1.2      0.029   14.7   1.2    1.6  1  PBP1_TM    Transmembrane domain of transglycosylase PBP1 at N
       0.18   10.7   5.8       0.28   10.0   5.8    1.3  1  LMBR1      LMBR1-like membrane protein
       0.42   11.2   5.0        1.6    9.4   0.2    3.2  3  QIL1       MICOS complex subunit MIC13, QIL1
        1.3    9.7   4.3        2.3    8.8   4.3    1.5  1  zf-CCCH_2  RNA-binding, Nab2-type zinc finger
          6    6.7   5.9         11    5.8   5.9    1.4  1  DUF4661    Domain of unknown function (DUF4661)


Domain annotation for each model (and alignments):
>> Torus  Torus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   1.0       3.2   5.8e+03       4      41 ..     185     222 ..     180     237 .. 0.45
   2 !   26.6   1.6   4.2e-09   7.5e-06      22      92 ..     439     512 ..     417     517 .. 0.60

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3.2
                 X----S-SS--------SSS-----TTSS----S-THH CS
       Torus   4 rparkqvdeeelksekeeqegeeyNiWynkwsgeekek 41 
                 ++a  q++++e +++++ ++ ++     +k ++ee++k
  EFC38910.1 185 KRADDQTSPQEETQTSNLNRSDSVESVTKKVKSEESSK 222
                 44444544444444333333334444444444322222 PP

  == domain 2  score: 26.6 bits;  conditional E-value: 4.2e-09
                 SS-----TTSS----S-THHHHS-----S--..--HHHH----HHH.HSTT--B-HHHHHT--SSGGG-SSB-S CS
       Torus  22 qegeeyNiWynkwsgeekekkkkskekaktr..cnikkdsGytkad.kekesyfClfFarGlCakGkkCeylHr 92 
                    +++N+ y+   + +++++  +k+k  t+   n k+    ++++ +  + + Cl+F +G C++G+kC ++H+
  EFC38910.1 439 MPPQQHNMNYHSQHSYQNNSSGAQKNKPPTNqySNSKQPPAQHQGEpRLFKPIKCLYFVKGQCKNGTKCPFYHE 512
                 333677888886665554444444443333200333333344444423445699*******************6 PP

>> Med26  TFIIS helical bundle-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.4   5.3e-07   0.00096      12      51 ..     108     147 ..      96     149 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 5.3e-07
                 ..HHHHHHSHHHHHHHHHH-TTS-HHHHHHHHHHHHHHHH CS
       Med26  12 ttetLkstgIGkvVnalrkhkhetaevktlAksLvekWkk 51 
                 ++ ++k+ +IGk+   ++k+++ ++ +kt + +L++ Wk+
  EFC38910.1 108 DVAIIKKAKIGKILSSISKSTNFSKTIKTSVDELIQDWKQ 147
                 56678999******************************96 PP

>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   4.9   4.9e-07   0.00088       1      17 [.     493     509 ..     493     511 .. 0.95

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 4.9e-07
   zf_CCCH_4   1 CkfflqGtCkkGdkCrF 17 
                 C +f++G+Ck+G+kC+F
  EFC38910.1 493 CLYFVKGQCKNGTKCPF 509
                 99**************9 PP

>> zf-CCCH_4  CCCH-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   3.1     1e-06    0.0018       3      22 .]     493     512 ..     492     512 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 1e-06
   zf-CCCH_4   3 CpyfakGsCrfGdnCrFsHd 22 
                 C yf+kG+C+ G +C F+H+
  EFC38910.1 493 CLYFVKGQCKNGTKCPFYHE 512
                 77*****************6 PP

>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   2.9   5.6e-06      0.01       2      25 ..     489     511 ..     488     512 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 5.6e-06
                 HCHCBCHHHHHS--TTGGG-SSBS CS
     zf-CCCH   2 ktelCrffmrtGyCkyGdrCkFaH 25 
                 k   C +f + G+Ck G +C+F H
  EFC38910.1 489 KPIKCLYFVK-GQCKNGTKCPFYH 511
                 5667999***.************9 PP

>> PBP1_TM  Transmembrane domain of transglycosylase PBP1 at N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   1.2   1.6e-05     0.029      18      73 ..     174     229 ..     166     239 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.6e-05
     PBP1_TM  18 akparkkasrrrrrdddyddeyddeedDdddddeeeevprkgkkkkpprkkrrwlw 73 
                 a+p+    ++r+r dd+   + + ++   +  d  e v++k k++++++kk+r+ w
  EFC38910.1 174 ATPTTTGGEKRKRADDQTSPQEETQTSNLNRSDSVESVTKKVKSEESSKKKKRVSW 229
                 345555556655556666667778888888999**********9999999998644 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   5.8   0.00016      0.28     183     353 ..      26     287 ..      24     298 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00016
       LMBR1 183 lvelPrslwreiksdldeelkklyfeaaklntekeeae...................................................reledllkev 230
                 +ve++++l    +s+  + ++ +++e  k+ ++  +++                                                   ++ + + k +
  EFC38910.1  26 FVEICKQLKY--TSSQADSIRLMRMECTKVLNSTVKKNilrdfltmdglsilsewitncsdhvdetmlkelisivnklnecggldvaiiKKAK-IGKIL 121
                 999*999955..999999********9999988888889************************************999999999999976665.77778 PP

       LMBR1 231 kklrksisesdplrkyleeilk...............................................kvPeeiaeklksnenkteeslaklekqlik 282
                 + ++ks+++s++++  ++e+++                                               ++P+e +++   ++ +  +s+ + +k++++
  EFC38910.1 122 SSISKSTNFSKTIKTSVDELIQdwkqkfvkegpttpttptetssptipkkkpatptttggekrkraddqTSPQEETQT---SNLNRSDSVESVTKKVKS 217
                 888888888887778888888899999999999888777777666666655555555555555555554444433333...222344577777788899 PP

       LMBR1 283 alqkrertekqwkrllekalele...............diiknksskekefkssessrrgefakqgklkltptleyywaklllplv 353
                 + + +++++  w++ lek+  +e               +++++++s+e+ +                   ++++++++   ++  v
  EFC38910.1 218 EESSKKKKRVSWSTELEKVRLIEprqayveevnhrsvqELMNEEKSNERVLMN----------------QQKQVKIMILSNMRNTV 287
                 99999999999999999995555555555544444444444444444444442................23333333333333333 PP

>> QIL1  MICOS complex subunit MIC13, QIL1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1      0.15   2.7e+02      17      62 ..      15      60 ..      11      64 .. 0.89
   2 ?    9.4   0.2   0.00089       1.6       6      47 ..     120     161 ..     119     168 .. 0.86
   3 ?   -2.5   0.1       4.7   8.4e+03      62      75 ..     348     361 ..     313     362 .. 0.69

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.15
        QIL1 17 ykkakeyipPyvdevkkklclevpklpsveevkfslveyWNkgVkk 62
                yk  k++  P++ e++k+l +   +  s + ++ +  +  N++Vkk
  EFC38910.1 15 YKITKKENLPAFVEICKQLKYTSSQADSIRLMRMECTKVLNSTVKK 60
                7778888889*********999999999999999999999999998 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00089
        QIL1   6 lWgsseeteelykkakeyipPyvdevkkklclevpklpsvee 47 
                 +++s ++++ + k +k+ + + ++++k+k+++e p  p++++
  EFC38910.1 120 ILSSISKSTNFSKTIKTSVDELIQDWKQKFVKEGPTTPTTPT 161
                 56777999**********************999888888775 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 4.7
        QIL1  62 kvfsflselPtyvk 75 
                 +++ ++s+ Pt+++
  EFC38910.1 348 NTIGIISNSPTSLN 361
                 46778888888775 PP

>> zf-CCCH_2  RNA-binding, Nab2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   4.3    0.0013       2.3       2      17 ..     493     511 ..     492     511 .. 0.93

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0013
   zf-CCCH_2   2 Crffpn..C.tnpkCpFaH 17 
                 C +f +  C  + kCpF+H
  EFC38910.1 493 CLYFVKgqCkNGTKCPFYH 511
                 99*******9999****** PP

>> DUF4661  Domain of unknown function (DUF4661)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   5.9    0.0063        11      27     110 ..     171     252 ..     146     291 .. 0.68

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0063
     DUF4661  27 dWdsaPetlGdvgppktkdsgarrssgaapelsreskveqlgskrmdslkldkavssteesgrleargaipklgsdpvdskgsk 110
                    ++P t G  ++ +++d ++ +++ ++++l+r  +ve + +k + s + +k+ + ++ s++le  + i    ++ v+  + +
  EFC38910.1 171 KKPATPTTTGGEKRKRADDQTSPQEETQTSNLNRSDSVESVTKKVK-SEESSKKKKRVSWSTELEKVRLIEP-RQAYVEEVNHR 252
                 456789*****************************99999876655.8888888888888889988887763.23333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (540 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2296  (0.128061); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.71u 0.35s 00:00:01.06 Elapsed: 00:00:00.51
# Mc/sec: 3209.08
//
Query:       EFC38911.1  [L=521]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    9.6e-16   58.2   0.1    3.8e-15   56.3   0.0    2.1  2  Rhodanese  Rhodanese-like domain


Domain annotation for each model (and alignments):
>> Rhodanese  Rhodanese-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.22     4e+03      32      73 ..      68     109 ..      54     134 .. 0.62
   2 !   56.3   0.0   2.1e-19   3.8e-15      11     106 ..     372     473 ..     362     474 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.22
   Rhodanese  32 gAvnvskdtlsrakkseapllelpeellel.gidnkktvvvyc 73 
                 ++v +  + + + ++  + ++e+ +++++l + ++  + +++c
  EFC38911.1  68 NSVQF-QQDQHQYSEYSEYDKENCTSFSPLeKKTKTCHSILLC 109
                 45555.4444444555555555556666655555566666666 PP

  == domain 2  score: 56.3 bits;  conditional E-value: 2.1e-19
   Rhodanese  11 kgkva....llDvRppeeYekghIpgAvnvskdtlsrakkseapllelpeellelgidnkktvvvycdgggr.aaaaaallk........k....lGyk 92 
                 +++ +    ++D+R+p+eY+ ghI+gA+n+        + ++  l + + e ++l    ++ +v++c+ ++  a   ++ ++             l ++
  EFC38911.1 372 DDNLKnqirIIDCRFPHEYQGGHIRGALNI--------WTPDVLLEQFFSEGMNL---SNQIIVFHCEYSQArAPKMYRYMRehdrklhlHeypiLSFP 459
                 444444566*********************........999999999*******9...**************66666777776666555505577889* PP

   Rhodanese  93 nvsvldGGfkawke 106
                 +++vl+GG+ka+ e
  EFC38911.1 460 DIYVLEGGYKAFWE 473
                 ***********976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (521 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1159  (0.0646439); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 3317.06
//
Query:       EFC38912.1  [L=726]
Description: hypothetical protein NAEGRDRAFT_52840 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0055   16.4   0.3     0.0055   16.4   0.3    4.0  4  IQ        IQ calmodulin-binding motif


Domain annotation for each model (and alignments):
>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.4      0.22     4e+03      11      20 ..     118     127 ..     117     127 .. 0.88
   2 !   16.4   0.3   3.1e-07    0.0055       2      20 ..     142     160 ..     141     161 .. 0.92
   3 ?    1.0   0.2     0.028     5e+02       5      17 ..     246     258 ..     242     261 .. 0.80
   4 !    7.7   0.8   0.00019       3.3       3      13 ..     284     294 ..     283     302 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.22
                 HHHHHHHHHH CS
          IQ  11 wRGylaRkry 20 
                 +R  ++R+ry
  EFC38912.1 118 IRSSKQRRRY 127
                 78999***99 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 3.1e-07
                 HHHHHHHHHHHHHHHHHHH CS
          IQ   2 kaaikIQaawRGylaRkry 20 
                 +aai IQ++++Gyl+R+ +
  EFC38912.1 142 SAAIEIQRCIKGYLTRRGF 160
                 69**************976 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.028
                 HHHHHHHHHHHHH CS
          IQ   5 ikIQaawRGylaR 17 
                  +IQ++++ y+ R
  EFC38912.1 246 SVIQSRYKLYRRR 258
                 68*****988766 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.00019
                 HHHHHHHHHHH CS
          IQ   3 aaikIQaawRG 13 
                 aa +IQ++wR 
  EFC38912.1 284 AAFIIQKWWRN 294
                 899*******6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (726 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1092  (0.0609069); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.49
# Mc/sec: 4449.33
//
Query:       EFC38913.1  [L=199]
Description: hypothetical protein NAEGRDRAFT_81424 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-08   33.9   4.9    3.6e-06   26.4   4.9    2.0  1  G-alpha      G-protein alpha subunit
    1.6e-05   25.0   0.2    1.9e-05   24.7   0.2    1.3  1  ATPase_2     ATPase domain predominantly from Archaea
  ------ inclusion threshold ------
      0.011   15.7   0.1      0.027   14.4   0.1    1.7  1  RsgA_GTPase  RsgA GTPase
      0.043   13.0   0.0      0.056   12.6   0.0    1.2  1  DUF815       Protein of unknown function (DUF815)
        0.2   12.1   0.8       0.44   11.1   0.8    1.6  1  ABC_tran     ABC transporter


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   4.9     1e-09   3.6e-06       7     210 ..      19     197 ..      13     198 .. 0.70

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 1e-09
                 XXXXXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HC CS
     G-alpha   7 idkslkaerkarkkkrevkllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkve 105
                 +++s+ + ++ + k++  +l+l G+++SGKs+i+k+   ++++++          ++++ +++      + + +l+s+l     +qe+ + ++  +++ 
  EFC38913.1  19 SQASIDEINNIKTKQQYKTLVLFGSGGSGKSSIFKKCVNIKEDSIL---------LVYSILLKF--YSWKYIPNLKSKL----TNQENVKLYETNLELL 102
                 44444444444444444589***************99977744332.........334433331..1133333333344....5666666666666666 PP

                 HHHH..........HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCGCCTT--..TTHHHHHCT..HHHHCST.T----CHHHHCS-----SEEEEEEECT CS
     G-alpha 106 asliaklssateeeqeiefnpraevgedikaLwndpgiqelyerrnkikle..dnaeyFldd..leritsp.dYlptddDilkarlktvGisetkfevd 199
                 + +i          +++ ++   +v++++ ++  d g+q+ + ++  ++++  ++++yF+++  ++++ +  +   +d+D+  a+ ktvGi+ + ++++
  EFC38913.1 103 PHHI----------EKTHWTV--DVANAVFKVYWDIGLQKELLNY-RFQIPfwESIQYFMKKenFDKLLDLnNCDLNDEDLFFASFKTVGIHSLPYKLN 188
                 6666..........5677777..8999999999999999887777.6776666*******95569999999899**********************998 PP

                 -TEEEEEEEE- CS
     G-alpha 200 sklefrivdvg 210
                  +++  i+d+g
  EFC38913.1 189 -ENQ-IIIDTG 197
                 .443.466665 PP

>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.7   0.2   5.3e-09   1.9e-05       6      82 ..      21      98 ..      17     170 .. 0.77

  Alignments for each domain:
  == domain 1  score: 24.7 bits;  conditional E-value: 5.3e-09
    ATPase_2  6 kelkeleeilerepneiyfiYGpegsGKtaLlkeiienledkdkyviyyialreesiskldefie..eeeekkklekal 82
                + ++e+++i  +++++ ++++G+ gsGK++++k+ ++ +ed +   +y i l+ +s +++ +     +++e+ kl ++ 
  EFC38913.1 21 ASIDEINNIKTKQQYKTLVLFGSGGSGKSSIFKKCVNIKED-SILLVYSILLKFYSWKYIPNLKSklTNQENVKLYETN 98
                6799**********************************977.7789999999988877776652244333333333333 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.1   7.5e-06     0.027      86     120 ..      22      56 ..      11      68 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 7.5e-06
                  THTTHHHHHHHCTTSEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  86 tkegleelkellkdktsvlvGqSGvGKStLinall 120
                  + ++++++k++ + kt vl G+ G GKS++ ++ +
   EFC38913.1  22 SIDEINNIKTKQQYKTLVLFGSGGSGKSSIFKKCV 56 
                  45788999999999***************988765 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.6e-05     0.056      45      84 ..      27      66 ..       6      95 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.6e-05
      DUF815 45 eqfleglpannvLLwGarGtGKSslvkallneyaeegLrl 84
                ++  ++++ + ++L+G+ G+GKSs+ k ++n  +++ L +
  EFC38913.1 27 NNIKTKQQYKTLVLFGSGGSGKSSIFKKCVNIKEDSILLV 66
                5555667778899****************99888777655 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.8   0.00012      0.44      10      34 ..      34      58 ..      26     138 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00012
                TTSEEEEEESTTSSHHHHHHHHTTS CS
                xxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran 10 egekvaivGenGaGKStLlkllagl 34
                + ++++++G+ G+GKS+++k   + 
  EFC38913.1 34 QYKTLVLFGSGGSGKSSIFKKCVNI 58
                457899************9965554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (199 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       876  (0.0488594); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 1322.37
//
Query:       EFC38914.1  [L=198]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (198 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       457  (0.0254894); expected 358.6 (0.02)
Passed bias filter:                      281  (0.0156729); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.44u 0.26s 00:00:00.70 Elapsed: 00:00:00.43
# Mc/sec: 1391.97
//
Query:       EFC38915.1  [L=233]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.083   12.9   0.6       0.13   12.2   0.6    1.3  1  RNA_pol_Rpb1_7  RNA polymerase Rpb1, domain 7
       0.46   10.5   7.3       0.36   10.8   4.6    1.9  2  SVA             Seminal vesicle autoantigen (SVA)


Domain annotation for each model (and alignments):
>> RNA_pol_Rpb1_7  RNA polymerase Rpb1, domain 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.6   1.5e-05      0.13      64     130 ..      68     135 ..      56     139 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.5e-05
                     T--HHHHHHHHHHHHTTT.EEEEE--TTSSSEEEEEEE------------..--HHHHTTHHHHHHHS CS
  RNA_pol_Rpb1_7  64 kltmeevaekikeefknd.lkvifsddnaeklvlririvkeekekeeeqedkaeddkfLkklesnlls 130
                     +l++++v+ ki+++  +   + + sddn+++++l +   +++++ e+++ ++a d ++ + +  ++ +
      EFC38915.1  68 SLSLSQVELKIQDNILTFsKSLLSSDDNNKQTILTCYSNNDDTTGEKHTCQMAIDTTTTRSICLKMKN 135
                     6899999999998876654668999***************9999888888887777777777666655 PP

>> SVA  Seminal vesicle autoantigen (SVA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.07   6.3e+02       3      24 ..      13      34 ..      11      84 .. 0.66
   2 ?   10.8   4.6     4e-05      0.36      22      92 ..      88     159 ..      69     164 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.07
         SVA  3 qllfrasavtllLilcLqleia 24
                +l++ a++++++Li+++  + +
  EFC38915.1 13 HLFISATTILFFLIISINAQSN 34
                5777888889999988876665 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 4e-05
         SVA  22 eiakgqen.rrkllllnlkvpstakkneevtvkltvktelkeCmvvkiylesnkpikgsfnykytaClCtdy 92 
                    ++ +n  + +l+   +   t+ +++  ++ ++ +t    C+ +k  l s+k++ ++ ny  ++C  +++
  EFC38915.1  88 SLLSSDDNnKQTILTCYSNNDDTTGEKHTCQMAIDTTTTRSICLKMKNTLSSDKKLSLAINYDSNNCASNNF 159
                 555677773445556666666777777778888888888899*************************98875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (233 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1026  (0.0572257); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.24s 00:00:00.74 Elapsed: 00:00:00.43
# Mc/sec: 1609.53
//
Query:       EFC38916.1  [L=426]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-23   83.7   5.7    2.1e-23   83.1   5.7    1.3  1  Pkinase         Protein kinase domain
    1.4e-11   44.2   0.5    2.4e-11   43.4   0.5    1.3  1  Pkinase_Tyr     Protein tyrosine kinase
    0.00083   18.2   0.0     0.0017   17.2   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.049   14.6   4.7        8.4    7.4   1.8    3.0  2  DUF3986         Protein of unknown function (DUF3986)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.1   5.7   4.6e-27   2.1e-23      13     212 ..     105     333 ..     103     402 .. 0.76

  Alignments for each domain:
  == domain 1  score: 83.1 bits;  conditional E-value: 4.6e-27
                 EEEEEEEETTTTEEEEEEEEECHCHCHHHH.....HHHHHHHHHHHHHS.CTTB--EEEEEEESSEEE..EEEE--TTEBHHHHHH..HHSS--HHHHH CS
     Pkinase  13 GkVykaveketgkivAvKkikkekakkkke.....kkvlrEikilkklk.hpnivrlyevfeekdely..lvleyveggeladlle..rkgslseeeak 101
                 G V+  +++e+++i    k+kk k   ++        ++r i+++k++   ++ + l+ + +++  ly  +vl++  ++  +++l+   + +l+++ + 
  EFC38916.1 105 GDVMLSTNTEKNRITSHRKMKKYKPIISRVknhhdIVIVRNISVFKEVGeEERRIILKLMNRDEYCLYlpIVLNIYAKDVEFEHLHslPSDHLDDNFLL 203
                 678888888888888888887765322211123458899999999999973333334444444444445589998888877777776888899999*** PP

                 HHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE......EEE-SGTTSEESSSSCS..............BCTTTSCGGGS-HHHHTTSCBSHHHHH CS
     Pkinase 102 kiakqilegleylHskgiiHrDlKpeNiLidekge......lKitDFGlakelesssk..............ltsfvgtseYlAPEvlkeneyskkvDv 180
                  +a +i  +l+ylH+++i+HrD+Kp+N +i   ++      + ++DFGl+ e+ +++               +++ vgt  + APEv k+++y++k+D+
  EFC38916.1 204 MMACHISIALKYLHANNIVHRDVKPSNTMIRPFNNptsllwIVLIDFGLSFEMVKEQGecyqlsssegkktlVNENVGTYLFQAPEVHKKQNYDEKIDI 302
                 *******************************544457999************99998899*************************************** PP

                 HHHHHHHHHHHHSS-STTTSSHHHHHHHHHHT CS
     Pkinase 181 WslGvilyelltgkppfsgekgkekvekeldq 212
                 +slG +l+ l  +k+ ++   +k+++  ++d 
  EFC38916.1 303 YSLGATLLYL-KNKTSYEIICKKDEFDLQVDM 333
                 *******999.455555545555555555554 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.4   0.5   5.3e-15   2.4e-11      37     196 ..     113     310 ..     104     337 .. 0.75

  Alignments for each domain:
  == domain 1  score: 43.4 bits;  conditional E-value: 5.3e-15
                  STTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE....SSSSEEEEEE--TTEBHHHHHHHT................CTTTSBHHHHHHHHHHHH CS
  Pkinase_Tyr  37 keeateeekeelleeakimkkl.khpnivkllgvct....keepllivteyvkgGdLlkfLrkk................ekekltlkdllsfalqvA 113
                  +e+++ ++++++ +   i++++ +h+ iv +  + +     ee+  i++++++  +   +L                    +++l+ + ll +a +++
   EFC38916.1 113 TEKNRITSHRKMKKYKPIISRVkNHHDIVIVRNISVfkevGEEERRIILKLMNRDEYCLYLPIVlniyakdvefehlhslPSDHLDDNFLLMMACHIS 210
                  55555566677777777888887777776555555444666677899999999998888888778889999999999999999*************** PP

                  HHHHHHHHTTEEEST-SGGGEEEEE......TTEEEE-STTTHEETTTSSEE....EETTSSTSGGG.......GS-HHHHHHSEEEHHHHHHHHHHH CS
  Pkinase_Tyr 114 kGmeyLeskklvHrdlaarNvLlse......nkvvkisDfGLardiekddey....vkkeeaklpvk.......WmapEslkekkftsksDvWsfGvl 194
                   +++yL+++++vHrd+   N +++          + + DfGL+ ++ k++      +++e++k+ v+       + apE+ k++++ +k D++s G +
   EFC38916.1 211 IALKYLHANNIVHRDVKPSNTMIRPfnnptsLLWIVLIDFGLSFEMVKEQGEcyqlSSSEGKKTLVNenvgtylFQAPEVHKKQNYDEKIDIYSLGAT 308
                  ***********************976666545578899*****999554432235533333333222222222277********************99 PP

                  HH CS
  Pkinase_Tyr 195 lw 196
                  l 
   EFC38916.1 309 LL 310
                  85 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.0   3.8e-07    0.0017     318     391 ..     212     296 ..     197     309 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 3.8e-07
  Pkinase_fungal 318 ghrsLflkagiLHrDiSenNilitdskke.gerkglLiDLDlakelsddsses.....ga......rertGTleFmaievlkgeeH 391
                     +++ L+   +i+HrD+   N +i   ++  +    +LiD+ l  e+ +++ e      ++      +e +GT  F a ev k+++ 
      EFC38916.1 212 ALKYLH-ANNIVHRDVKPSNTMIRPFNNPtSLLWIVLIDFGLSFEMVKEQGECyqlssSEgkktlvNENVGTYLFQAPEVHKKQNY 296
                     678899.9****************5555524555689*********98666655554411445666789******99999887664 PP

>> DUF3986  Protein of unknown function (DUF3986)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.0    0.0034        15      19      83 ..     155     221 ..     139     227 .. 0.71
   2 ?    7.4   1.8    0.0019       8.4      17      79 ..     302     363 ..     288     375 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0034
     DUF3986  19 dlEaiayKrknedvWvvyfdf..edygvekdelslskf.dkyalfdkyGykv.ysikakdldeeeaskl 83 
                 +   i +K +n d +++y+++  + y ++++  +l+ + +++ l d++  ++  +i +  l++ +a+++
  EFC38916.1 155 EERRIILKLMNRDEYCLYLPIvlNIYAKDVEFEHLHSLpSDH-LDDNFLLMMaCHI-SIALKYLHANNI 221
                 445799*************99777777777766666664444.5677766664666.777777777766 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0019
     DUF3986  17 nldlEaiayKrknedvWvvyfdfedygvekdelslskfdkyalfdkyGykvysikakdldeee 79 
                 ++ l a+ +  kn+  + +  + ++++ ++d +++ ++d++++ +ky   +++i+ kdl+ + 
  EFC38916.1 302 IYSLGATLLYLKNKTSYEIICKKDEFDLQVD-MQTLQWDDFKFGKKYWKWLMKIQRKDLQLKS 363
                 45668888999999**************999.**********9999*************9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (426 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1004  (0.0559987); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 2600.98
//
Query:       EFC38917.1  [L=754]
Description: TTK family protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.4e-54  181.6   7.4    3.3e-16   58.7   0.0    6.4  7  DUF4116      Domain of unknown function (DUF4116)
    5.4e-24   85.0   3.1    5.4e-24   85.0   3.1    3.2  3  Pkinase      Protein kinase domain
    3.6e-10   39.6   0.2    1.6e-08   34.1   0.0    2.4  2  Pkinase_Tyr  Protein tyrosine kinase
  ------ inclusion threshold ------
       0.27   11.6   8.0       0.24   11.7   4.7    2.8  2  Csm1_N       Csm1 N-terminal domain
       0.52   10.4   8.3       0.42   10.7   4.8    2.7  2  APC_N_CC     Coiled-coil N-terminus of APC, dimerisation doma
        1.1    9.3   6.6       0.34   11.0   2.6    2.3  2  Rab_bind     Rab binding domain
        4.8    7.9   8.9         17    6.1   5.0    3.0  2  YabA         Initiation control protein YabA
        7.2    7.0  12.4        0.3   11.4   2.5    3.9  4  DUF5638      Family of unknown function (DUF5638)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.6   0.1   1.7e-19   3.7e-16       1      49 []       6      54 ..       6      54 .. 0.97
   2 !   58.7   0.0   1.5e-19   3.3e-16       1      45 [.      56     100 ..      56     103 .. 0.98
   3 !   57.3   0.1   4.2e-19   9.5e-16       1      49 []     104     152 ..     104     152 .. 0.98
   4 !   34.1   0.3   7.2e-12   1.6e-08       1      42 [.     129     170 ..     129     177 .. 0.91
   5 ?   -1.9   0.3       1.3   2.9e+03      15      29 ..     352     366 ..     335     368 .. 0.65
   6 ?   -2.0   0.1       1.3     3e+03       8      20 ..     595     607 ..     593     608 .. 0.71
   7 ?   -1.9   0.0       1.3     3e+03      13      24 ..     674     685 ..     671     689 .. 0.79

  Alignments for each domain:
  == domain 1  score: 58.6 bits;  conditional E-value: 1.7e-19
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                + Eivleavk+ngsalky+++ Lk+D+eivl+ vk ng+al+y++ +L+
  EFC38917.1  6 NIEIVLEAVKHNGSALKYADSLLKRDREIVLESVKHNGSALKYVDSSLK 54
                68******************************************99986 PP

  == domain 2  score: 58.7 bits;  conditional E-value: 1.5e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 DrEivle vk+ngsal+y++  Lk+D+eivl+Avkq+g al+ya+
  EFC38917.1  56 DREIVLESVKQNGSALQYADLLLKKDREIVLEAVKQDGLALEYAY 100
                 9******************************************95 PP

  == domain 3  score: 57.3 bits;  conditional E-value: 4.2e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivle vk+ngsal y+++ +k+D+eivl+Avkq+  al+ya+ +L+
  EFC38917.1 104 DREIVLESVKQNGSALVYADSLFKRDREIVLEAVKQHELALEYADSSLQ 152
                 9*******************************************99886 PP

  == domain 4  score: 34.1 bits;  conditional E-value: 7.2e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 DrEivleavk++ +al+y++++L++D+ ++   vk n+ + +
  EFC38917.1 129 DREIVLEAVKQHELALEYADSSLQRDIIFIYSLVKLNKENTR 170
                 9************************************97655 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 1.3
     DUF4116  15 alkylseeLknDkei 29 
                 al+y+ + +k + ++
  EFC38917.1 352 ALNYFYNYFKYNYDF 366
                 455555555555555 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 1.3
     DUF4116   8 avkkngsalkyls 20 
                 a++k++ ++ y+s
  EFC38917.1 595 AISKYNDNYPYFS 607
                 6777777777776 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 1.3
     DUF4116  13 gsalkylseeLk 24 
                  ++lk+l +e+k
  EFC38917.1 674 ENILKFLKDEIK 685
                 578888888887 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.34   7.7e+02      32      80 ..     164     217 ..     153     256 .. 0.77
   2 ?   -0.8   0.1      0.35   7.8e+02      70     115 ..     313     357 ..     265     360 .. 0.62
   3 !   85.0   3.1   2.4e-27   5.4e-24       1     196 [.     364     584 ..     364     664 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.34
                 EECHCHCHHHH..HHHHHHHHHHHHHS.CTTB-..-EEEEEEESSEEEEEEE-- CS
     Pkinase  32 ikkekakkkke..kkvlrEikilkklk.hpniv..rlyevfeekdelylvleyv 80 
                 ++ke++++ +   +k+++E +i  + k ++ni+  ++ ++f ++++ly   e+ 
  EFC38917.1 164 LNKENTRSFSPsiTKTIEEANINLQRKlSSNIIeqQYSKIFMDEKDLYYAIELT 217
                 555555555556778999999988888899999444778999999999888875 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.35
                 SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHH CS
     Pkinase  70 kdelylvleyveggeladllerkgslseeeakkiakqilegleylH 115
                 ++ +++ + + e+++ ++ ++ + + + +e++  +++++++l+y +
  EFC38917.1 313 NEIMIFSNKWFENEQTFENYK-QIVCKYNEVRGDLSKVFKALNYFY 357
                 333445556666666666664.466777777777778888888776 PP

  == domain 3  score: 85.0 bits;  conditional E-value: 2.4e-27
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH........H CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle........r 91 
                 y  ++ lG G+ G+ +k+++k+++   A+K     ++++++   + + i++lk+++ +  ++++++   +++ly v+e+ e+  l +++         r
  EFC38917.1 364 YDFISVLGYGGEGVAFKVFHKSSKSLRALKLKYDPEESEES---TKETINLLKRTDIEGKIKCFDCEIIQNHLYSVMELGEES-LSNYIYrnnqdgiyR 458
                 567789***********************987766666644...56779********************************66.666555588888877 PP

                 HSS--HH...HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.................. CS
     Pkinase  92 kgslsee...eakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl.................. 169
                 +g +++e   e+ +i+ ++l++++ +H+++i+HrDl p+Ni    ++  Ki+DF  ++ ++++++ t   g   Y++PEv                   
  EFC38917.1 459 NGFIKKEkliEILEIFIKVLNSVKSIHDHNILHRDLDPQNIVKV-QDLYKIIDFETSRVIKTGNSITIARGKFAYMSPEVShdnysddllksgndekla 556
                 77777776666778999************************999.899********************************9998888888776655543 PP

                 .TTSCBSHHHHHHHHHHHHHHHHHSS-S CS
     Pkinase 170 .keneyskkvDvWslGvilyelltgkpp 196
                  +  +++ ++D++slG+il++llt++p+
  EFC38917.1 557 hNVGQITISCDIFSLGCILLKLLTNCPL 584
                 3337889*****************9876 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.025        57      86     118 ..     272     304 ..     247     310 .. 0.86
   2 !   34.1   0.0   7.2e-12   1.6e-08      35     217 ..     391     598 ..     366     608 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.025
                  EBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr  86 GdLlkfLrkkekekltlkdllsfalqvAkGmey 118
                    L+kfL+++ ++++++kdl +++ qvA   e 
   EFC38917.1 272 FRLDKFLEDNPSQSTRMKDLKNIVEQVATNFET 304
                  579*************************87765 PP

  == domain 2  score: 34.1 bits;  conditional E-value: 7.2e-12
                  EESTTSSHHH.HHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT.........CTTTSBHHHHHHHHHHHHHHHHHHHHT CS
  Pkinase_Tyr  35 tlkeeateee.keelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk.........ekekltlkdllsfalqvAkGmeyLesk 122
                   lk +++ ee +e+  e ++++k+++ +  +k+  + + +++l+ v+e+ ++ +L++++ ++           +k +l ++l++ ++v + ++ ++++
   EFC38917.1 391 ALKLKYDPEEsEESTKETINLLKRTDIEGKIKCFDCEIIQNHLYSVMELGEE-SLSNYIYRNnqdgiyrngFIKKEKLIEILEIFIKVLNSVKSIHDH 487
                  3444455455145566678999999*99999***999999********9765.9******99999999888455556788999*************** PP

                  TEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE...................EEHHHHHHHHHHHHHHHHTT CS
  Pkinase_Tyr 123 klvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk...................ftsksDvWsfGvllwEiftl 201
                  +++Hrdl  +N+ ++ +++ ki Df  +r i   ++ ++ + a+  + +m+pE+ +++                    +t + D++s G +l  ++t+
   EFC38917.1 488 NILHRDLDPQNI-VKVQDLYKIIDFETSRVI---KTGNSITIARGKFAYMSPEVSHDNYsddllksgndeklahnvgqITISCDIFSLGCILLKLLTN 581
                  ***********9.67799*************...44455567788899*******9998899999999999999999999999999999999999998 PP

                  SSGTTTTS.HHHHHHHH CS
  Pkinase_Tyr 202 gespypgl.kneevlek 217
                  +   + +   n ++++k
   EFC38917.1 582 CPLQLCSTfVNDSAISK 598
                  76554443355555555 PP

>> Csm1_N  Csm1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       4.3   9.6e+03      39      56 ..     284     301 ..     279     311 .. 0.65
   2 ?   11.7   4.7   0.00011      0.24      22      61 ..     714     753 ..     710     754 .] 0.95

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4.3
      Csm1_N  39 kdqeiesLkeqlaeleek 56 
                 ++++++ Lk+ ++++ ++
  EFC38917.1 284 QSTRMKDLKNIVEQVATN 301
                 556666677666666554 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00011
      Csm1_N  22 vsklvhENsvLsqkletkdqeiesLkeqlaeleekvkele 61 
                 v kl +EN+ L + l+  ++e ++L e+++ lee++++l+
  EFC38917.1 714 VDKLAEENTNLYKLLDENTRENSNLLERIKMLEEEIRKLK 753
                 89*********************************99987 PP

>> APC_N_CC  Coiled-coil N-terminus of APC, dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       1.1   2.5e+03      22      45 ..     276     295 ..     273     301 .. 0.67
   2 ?   10.7   4.8   0.00019      0.42       2      33 ..     706     741 ..     705     754 .] 0.70

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.1
    APC_N_CC  22 rELedNSshLskLEtetsgmKevl 45 
                 + LedN s+ +++     ++K+++
  EFC38917.1 276 KFLEDNPSQSTRM----KDLKNIV 295
                 5689999998776....3555555 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00019
    APC_N_CC   2 sYdQLvrQvEaLkkenthlrrEL....edNSshLsk 33 
                 sY QL+  v  L  ent+l + L    ++NS+ L +
  EFC38917.1 706 SYSQLAEEVDKLAEENTNLYKLLdentRENSNLLER 741
                 8*******************9992222445665554 PP

>> Rab_bind  Rab binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       1.9   4.2e+03      47      62 ..     677     692 ..     671     694 .. 0.77
   2 ?   11.0   2.6   0.00015      0.34      25      58 ..     720     753 ..     704     754 .] 0.82

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.9
    Rab_bind  47 ikLLksevrrLernqe 62 
                 +k Lk+e++ +  n e
  EFC38917.1 677 LKFLKDEIKDITLNIE 692
                 489*****99888776 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00015
    Rab_bind  25 svdhlngLLreteatnavLmeqikLLksevrrLe 58 
                     l  LL e    n+ L+e+ik+L +e+r+L 
  EFC38917.1 720 ENTNLYKLLDENTRENSNLLERIKMLEEEIRKLK 753
                 5556889*************************96 PP

>> YabA  Initiation control protein YabA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.1      0.14   3.2e+02      15      68 ..     279     341 ..     270     357 .. 0.64
   2 ?    6.1   5.0    0.0076        17       5      74 ..     683     750 ..     678     754 .] 0.66

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.14
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.........XXXXXXXXXXXXXXXX CS
        YabA  15 eqleelleeleelkeelaelleenaeLeleneklrerl.........eeeekkekekkkelse 68 
                 e+  + ++++++lk+ ++++  + ++L   ++++ e +         e++ ++ k+   + +e
  EFC38917.1 279 EDNPSQSTRMKDLKNIVEQVATNFETLFYTKQEINEIMifsnkwfenEQTFENYKQIVCKYNE 341
                 555566778888888888888888888888888888886666665433333333333444444 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0076
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHXXXXXXXXXXXXXXXXXXXXXX CS
        YabA   5 elfdkleeleeqleelleeleelkeelaelleenaeLeleneklrerleeeekkekekkkelsegkenLa 74 
                 e+ d   ++e+q++el ++++ l+ + ++l ee ++L  en++l ++l+e+++++++  ++++  +e+++
  EFC38917.1 683 EIKDITLNIEKQVGEL-KKISPLR-SYSQLAEEVDKLAEENTNLYKLLDENTRENSNLLERIKMLEEEIR 750
                 3333344445555443.3455554.67899******************8888887776666666555555 PP

>> DUF5638  Family of unknown function (DUF5638)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       4.9   1.1e+04      66      86 ..     133     153 ..     132     155 .. 0.81
   2 ?   11.4   2.5   0.00013       0.3       7      70 ..     286     349 ..     280     356 .. 0.88
   3 ?   -1.0   0.1      0.97   2.2e+03      22      77 ..     487     544 ..     463     559 .. 0.71
   4 ?   -2.7   0.1       3.3   7.3e+03       5      26 ..     575     597 ..     574     601 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 4.9
                 HHHHHHTTSS-HHHHHHHHTT CS
     DUF5638  66 llsqvkngeisadeAleaiek 86 
                  l+ vk+ e+ ++ A +++++
  EFC38917.1 133 VLEAVKQHELALEYADSSLQR 153
                 58999**99999999887765 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00013
                 HHHHHHHHHHHHHT------HHHHHHHHHHHHHHHHHHHT--SHHHHHHHHHHHHHHHHHHHHH CS
     DUF5638   7 krLseCdeklsalfedkelsekikkqlqeiktyYnesftkakkektkeeiveeYeelvlllsqv 70 
                  r+++ ++ ++++ ++ e+   +k++++ei  + n+ f++ +  ++ ++iv +Y+e    ls+v
  EFC38917.1 286 TRMKDLKNIVEQVATNFETLFYTKQEINEIMIFSNKWFENEQTFENYKQIVCKYNEVRGDLSKV 349
                 57777777788888899999999*********************************99999988 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.97
                 -----HHHH.HHHHHHHHHHHH.HHHT--SHHHHHHHHHHHHHHHHHHHHHHTTSS-H CS
     DUF5638  22 dkelsekik.kqlqeiktyYne.sftkakkektkeeiveeYeelvlllsqvkngeisa 77 
                 ++ l++++  +++ ++++ Y+   f+ ++  kt+++i+    ++  +  +v++ ++s 
  EFC38917.1 487 HNILHRDLDpQNIVKVQDLYKIiDFETSRVIKTGNSITIARGKFAYMSPEVSHDNYSD 544
                 4445554432678889998885258888888888888877777777777777777765 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 3.3
                 HHHHHHHHHHHHHHHT.------ CS
     DUF5638   5 lekrLseCdeklsalf.edkels 26 
                 l k L++C  +l + f +d  +s
  EFC38917.1 575 LLKLLTNCPLQLCSTFvNDSAIS 597
                 67899****99988885665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (754 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1357  (0.0756874); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 4401.56
//
Query:       EFC38918.1  [L=1172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-49  168.0   2.6    3.4e-29  102.1   0.7    2.8  2  ABC_tran         ABC transporter
    1.1e-41  143.3  40.7    3.7e-27   95.7  18.7    2.2  2  ABC_membrane     ABC transporter transmembrane region
    5.8e-06   26.3   1.0      0.038   13.9   0.1    2.8  2  RsgA_GTPase      RsgA GTPase
    2.3e-05   23.9  12.2      0.098   12.1   4.5    4.1  2  SMC_N            RecF/RecN/SMC N terminal domain
    6.1e-05   23.1   0.0      0.086   12.9   0.0    3.2  3  MMR_HSR1         50S ribosome-binding GTPase
      8e-05   23.1   0.2     0.0052   17.2   0.1    3.2  3  AAA_16           AAA ATPase domain
    0.00043   19.8   0.1      0.048   13.2   0.0    2.5  2  AAA_7            P-loop containing dynein motor region
    0.00045   20.5   0.2      0.029   14.6   0.3    3.3  2  AAA_22           AAA domain
     0.0014   18.3   0.7      0.055   13.2   0.0    2.6  2  AAA_29           P-loop containing region of AAA domain
     0.0063   16.7   0.0        0.2   11.9   0.0    3.2  3  Roc              Ras of Complex, Roc, domain of DAPkinase
  ------ inclusion threshold ------
      0.012   15.7   4.2      0.075   13.1   0.1    3.0  2  DUF87            Helicase HerA, central domain
      0.029   14.8   0.1        2.1    8.8   0.0    3.2  3  RNA_helicase     RNA helicase
      0.046   13.5   0.0       0.76    9.5   0.0    2.6  2  Viral_helicase1  Viral (Superfamily 1) RNA helicase
       0.05   12.9   0.0       0.17   11.2   0.0    1.8  2  FtsK_SpoIIIE     FtsK/SpoIIIE family
       0.05   13.4   6.2        2.5    7.9   0.0    3.9  4  AAA_21           AAA domain, putative AbiEii toxin, Type IV T
      0.099   12.4   1.2        2.6    7.7   0.0    3.5  4  IstB_IS21        IstB-like ATP binding protein
       0.16   11.6   0.6        3.1    7.5   0.2    2.6  2  AAA_24           AAA domain
       0.19   11.6   0.5        3.2    7.7   0.0    3.1  3  NACHT            NACHT domain
       0.65    8.8   3.7        0.3   10.0   0.1    2.3  3  TrwB_AAD_bind    Type IV secretion-system coupling protein DN
       0.95    9.5  11.9          2    8.4   0.2    3.9  3  Dynamin_N        Dynamin family


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.9   0.0   1.2e-20   1.1e-17       1     136 [.     306     447 ..     306     448 .. 0.81
   2 !  102.1   0.7   3.8e-32   3.4e-29       1     137 []     928    1096 ..     928    1096 .. 0.96

  Alignments for each domain:
  == domain 1  score: 64.9 bits;  conditional E-value: 1.2e-20
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH......HHHTCHHHHHHHST CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren......esdeeiekalsklg 93 
                 lk+++lk+k+ge v i+G+ G  KS+Ll+ l+g+++  e +       +    ++ ++ + +++ q++ + +++ +ren       ++e+ +++l+  +
  EFC38918.1 306 LKEINLKIKKGEFVCIIGRVGQSKSSLLSSLLGEMNFIESQD------SFF--EKDSNLKYSYVAQDSWIRNQT-IRENilfgeeFDKERYQQVLHACN 395
                 799********************************9765554......444..678888********7777777.********9744444555666665 PP

                 TGG.........TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTT CS
                 xxx.........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  94 lke.........lkdtvvksspssLSgGqkqrvalarallkkpkllllDEpt 136
                 l+           + t +++s+ +LSgGqk r++lar++ ++++++llD+p 
  EFC38918.1 396 LEPdlqqiskeiGDMTMIGESGINLSGGQKLRISLARCFYSNADVFLLDDPL 447
                 5554444444445666778888****************************97 PP

  == domain 2  score: 102.1 bits;  conditional E-value: 3.8e-32
                  EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--.SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH......HHHTCHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxx RF
    ABC_tran    1 lknvslklkegekvaivGenGaGKStLlkllagllkp.teGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren......esdeeiekals 90  
                  lk ++lk+++ e+v i G++G+GKS+L++ l+++ +  +e +il+dg d+++ +le lr+ + ++pq+p+lf+++ +ren      + d+e+ +al+
  EFC38918.1  928 LKGINLKINAKERVSICGRTGSGKSSLIQSLMRMQEIeQESTILIDGIDIRNVPLETLRSTMCIIPQQPTLFKGT-LRENldsysqYTDRELWDALE 1023
                  789***************************99987665999**********************************.*********999999****** PP

                  HSTTGG..........................TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                  xxxxxx..........................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   91 klglke..........................lkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137 
                  k+g+k+                            +t ++++++++S G +q ++laral++k+k+l+lDE+ta
  EFC38918.1 1024 KVGMKDkldqlqslddedeeksekevitikptGLETEISENGENISAGTRQLLCLARALIRKSKILILDEATA 1096
                  ******************************997788888999*****************************96 PP

>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.4  14.0   3.2e-17   2.9e-14      45     267 ..       3     224 ..       1     230 [. 0.84
   2 !   95.7  18.7   4.1e-30   3.7e-27       2     255 ..     591     839 ..     589     858 .. 0.93

  Alignments for each domain:
  == domain 1  score: 53.4 bits;  conditional E-value: 3.2e-17
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSH CS
  ABC_membrane  45 llllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgw 141
                   ll++++  +++++    +++   +ge +s+ l + +++k+lr++ s   + s+G++++  t+d+s++ +++ + + +++ s++tf + l +++ l  
    EFC38918.1   3 LLMFIFKSIRCFTDDHVTFIAQQLGESTSNSLLNAIYRKVLRMSNSSKHEYSTGSVMNIATTDASRFPWFY-YYIETVIASMMTFAACLWFSCNLLG 98 
                   44444444444444456677799******************************************998776.78********************888 PP

                   HHHHHHHHH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane 142 kltlvllai.lpliilvsaviakilkklkkkeqkavakassvaeEslsgirtVkafgreeyflekfekaleeakkagikkaianglligitqllgll 237
                     +l +++i l+l++++sa ++ + +k+++    + +++s+++ ++++++r Vk +++e+ f +k+ + +e + k+ +k  i+++ +++  ++++  
    EFC38918.1  99 ISALFGFSIiLILVLPLSAACMIWEQKIEEIIEANQDERSQIISQMVYAMRFVKFYTMEKLFKRKIMNIREVEMKNIKKGYISDSGMSVLWNAFAPM 195
                   8888888661566778************************************************************666666666666665555555 PP

                   HHHHHHHHHHHHHHTTSSTHHHHHHHHHHH CS
  ABC_membrane 238 syalalwfGttlvisgelsvgdlvvflslf 267
                   + ++  ++ + +v+  +lsv++ + fls +
    EFC38918.1 196 ISFVS-FLHFCYVKGETLSVSTSFSFLSAL 224
                   55555.8899999999******99998865 PP

  == domain 2  score: 95.7 bits;  conditional E-value: 4.1e-30
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHSCHH CS
  ABC_membrane   2 iliillailagvlsplfplvlgrildtlldkgdpetealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtnsvG 98 
                    li+++ai+++++ +   +vl+ + ++      +++ +l  y+l++l+  l+ +++ + + +l+ +   ++ k l+ kl+ +i++  ++ffd+++vG
    EFC38918.1 591 ALICFCAIIQQLVTVGHQYVLSLWSNDSE---YQSF-TLLTYLLAYLGTSLIYIVADISSGFLCLIHFLNTAKLLHEKLMTSIIHSCIAFFDSTPVG 683
                   57899999999999999999999988774...3333.68999999999999999999999999999******************************* PP

                   HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHH CS
  ABC_membrane  99 ellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgirtVka 195
                   ++++r+t+d++++++ l+ +l +++ +++  +gg+i +++++++  + +++++p+i++v+ ++   l++++     + ++++s + E++ g++t++a
    EFC38918.1 684 RIIARFTRDTNSIDTDLNKNLAQLIPYFFFWIGGIITVMIMSPYSIIPVVILSPVIFFVQSYYRVSLREIELLAGVYSSPVNSQLSETIHGLQTIRA 780
                   ************************************************************************************************* PP

                   TTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSS CS
  ABC_membrane 196 fgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgel 255
                   fg+++  +e f ++ e+  + ++ +  +++ +++++++++ l+++l+  ++++l+ sg l
    EFC38918.1 781 FGKQNLLVESFIEKAETQARVSYNSHCLSAYFNMRNEVVFALCVSLI-IISSVLSFSGSL 839
                   ***********************************************.889999988743 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.1   0.00067       0.6      76     124 ..     292     341 ..     260     353 .. 0.81
   2 !   13.9   0.1   4.2e-05     0.038      64     126 ..     903     965 ..     862     972 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00067
                  TSEEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT-- CS
  RsgA_GTPase  76 gyevllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinallpele 124
                    + l+++++ + +l+e++ ++k+ ++++++G  G  KS+L+ +ll+e++
   EFC38918.1 292 TWDSLKCESSPTITLKEINLKIKKgEFVCIIGRVGQSKSSLLSSLLGEMN 341
                  3466777777788999**9999998********************99875 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 4.2e-05
                  HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT---- CS
  RsgA_GTPase  64 eleelkeelealgyevllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinallpelelk 126
                  e++++  ++++  +e+   +++ k  l+ ++ +++  + + ++G +G GKS+Li +l+  +e++
   EFC38918.1 903 EMKNVCMRYKKHTFETEPAEQN-KLVLKGINLKINAkERVSICGRTGSGKSSLIQSLMRMQEIE 965
                  4555666666666655555333.5566777777766577889***************9876554 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.9    0.0017       1.5     115     207 ..     243     487 ..     226     497 .. 0.71
   2 !   12.1   4.5   0.00011     0.098      37     211 ..     951    1139 ..     928    1142 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0017
                 TEEE-HHHHHHHHHCTT-STT.............................................................................. CS
                 xxxxxxxxxxxxxxxxxxxxx.............................................................................. RF
       SMC_N 115 gkevtkkevsellesagiske.............................................................................. 135
                 +   ++k + +ll+s++is++                                                                              
  EFC38918.1 243 RACTSFKRIIKLLSSEEISESstdsnnkemenqkilekdlvaeyanasftwdslkcessptitlkeinlkikkgefvciigrvgqskssllssllgemn 341
                 555556666666666666666666666666666666667777777777777777777777777777777777777777777777777777777777777 PP

                 .............................................................................CS-HHHHHHHHHHHHHHHHCCS CS
                 .............................................................................xxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 .............................................................................lLSgGektLvalaLlfAiqkvk 157
                                                                                              +LSgG+k  ++la       ++
  EFC38918.1 342 fiesqdsffekdsnlkysyvaqdswirnqtirenilfgeefdkeryqqvlhacnlepdlqqiskeigdmtmigesgiNLSGGQKLRISLARC----FYS 436
                 7777777777777777777777777777777777777777777777777777777777**************************76666655....589 PP

                 --SEEEECTTTTTS-HHHHHHHHHH.HHHHCTTSEEEEE-SSHHHCCC-SC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 158 paplyllDeidaaLDeknvkkvael.lkeksknaQfivislreemlekadk 207
                  a ++llD+  +a D +    + ++ +    k    ++++ + +++ kad+
  EFC38918.1 437 NADVFLLDDPLSAVDVHTADHIMKYgIYGFLKGKTTLMVTNQIHFIDKADR 487
                 999999**9999999999988887745555555555555555555555555 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 0.00011
                  HHHHHHHHHHHCTT.TTTTTTCHCCCCCC--BTTCSSTTEEEEEEEEEETTEESSSSSSCEEEEEEEETTSEEEEEETTEEE-HHHHHHHHHCTT-S CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N   37 KsnlldAilFvLGersakklrseklsdlihkskekasvkkaeveitfdnedkklkiekeevsisrrvkrkgeseykingkevtkkevsellesagis 133 
                  Ks+l+                                                                                  ++l+++++i+
  EFC38918.1  951 KSSLI----------------------------------------------------------------------------------QSLMRMQEIE 965 
                  33333..................................................................................4444444444 PP

                  TT............................................................................................... CS
                  xx............................................................................................... RF
       SMC_N  134 ke............................................................................................... 135 
                  +e                                                                                               
  EFC38918.1  966 QEstilidgidirnvpletlrstmciipqqptlfkgtlrenldsysqytdrelwdalekvgmkdkldqlqslddedeeksekevitikptgleteis 1062
                  4444444444444444444444444444466666666666666666666666666666666666666666666666666666777777777777788 PP

                  ....CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHH.HHCTTSEEEEE-SSHHHCCC-SCEEEE CS
                  ....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N  136 ....lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellk.eksknaQfivislreemlekadklvgv 211 
                      ++S G ++L+ la       ++++ + +lDe  a  D +  k + + l+ e s+n+ +i++++r e++ + dk+v +
  EFC38918.1 1063 engeNISAGTRQLLCLA----RALIRKSKILILDEATALCDLETDKLIQKTLReEFSSNCTVICVAHRLETILDYDKIVVI 1139
                  888899***99997665....55689999***********************9455778************9999998765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0    0.0096       8.6       2      35 ..     319     353 ..     318     419 .. 0.88
   2 ?   -2.9   0.0       7.9   7.1e+03      63      84 ..     472     493 ..     453     541 .. 0.63
   3 !   12.9   0.0   9.6e-05     0.086       1      22 [.     940     961 ..     940     992 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0096
                 EEEEESTTSSHHHHHHHHHTS.TEEESSSTTSSSS CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltge.kaivsdkpgtTrd 35 
                 v+i+Gr    KS+L+++l+ge + i s+  +  +d
  EFC38918.1 319 VCIIGRVGQSKSSLLSSLLGEmNFIESQDSFFEKD 353
                 89******************977777776665555 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 7.9
                 HHHHHHHHHHHHCTSEEEEEEE CS
    MMR_HSR1  63 ekglgkaflaleeadlillvvd 84 
                   +++++++ +++ad il++ +
  EFC38918.1 472 TLMVTNQIHFIDKADRILVMDQ 493
                 3356666666666666554433 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 9.6e-05
                 EEEEEESTTSSHHHHHHHHHTS CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltge 22 
                 +v i Gr+ +GKS+Li++l++ 
  EFC38918.1 940 RVSICGRTGSGKSSLIQSLMRM 961
                 689****************984 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0      0.36   3.3e+02      24     106 ..     316     408 ..     306     452 .. 0.64
   2 ?   -1.8   0.0       4.1   3.6e+03      36     103 ..     469     536 ..     469     590 .. 0.51
   3 !   17.2   0.1   5.7e-06    0.0052      25     170 .]     939    1121 ..     931    1121 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.36
      AAA_16  24 pelvllsGesGvGKsslvrellr...alekd...........ggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawrekleeala 106
                 +e v ++G  G  Kssl+ +ll     +e +           + ++++  + ++++ ++ + + + +++ e ++q+l +   ++le++ +++ ++++
  EFC38918.1 316 GEFVCIIGRVGQSKSSLLSSLLGemnFIESQdsffekdsnlkYSYVAQDSWIRNQTIRENILFGEEFDK-ERYQQVLHA---CNLEPDLQQISKEIG 408
                 4789999***********999963432333356666667776577777777777444444556666655.666666666...777777777777777 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 4.1
      AAA_16  36 GKsslv..rellralekd........ggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawreklee 103
                 GK++l+  ++++  + k+        g i+ +g++++l        + + l ++ l+ +  ++ +++++e+ +  ++e
  EFC38918.1 469 GKTTLMvtNQIH-FIDKAdrilvmdqGRIVQQGTFTEL--------YQEDLNFKNLIDEFSSNNKNNQQEERDL-FDE 536
                 778777666666.5555555555555566677777777........3333434444444444433322222222.222 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 5.7e-06
      AAA_16   25 elvllsGesGvGKsslvrellr..alekd............................ggif...lrgkcdqlesaipy.sa.laqalareellrqll 86  
                  e v + G  G+GKssl+++l+r  ++e++                              +f   lr++ d++     y +  l++al++   +++ l
  EFC38918.1  939 ERVSICGRTGSGKSSLIQSLMRmqEIEQEstilidgidirnvpletlrstmciipqqPTLFkgtLRENLDSY---SQYtDReLWDALEK-VGMKDKL 1031
                  568899***************877888887777777777777777777766666653122233344444444...55554447777755.6666666 PP

      AAA_16   87 deaesaeleawrekleealaavpelagaea.........srllellkrllallsrderplvlvlDdlq.wadeaslqllaaLlrlleskpllvv 170 
                  d+++s + +++ ek e+++  +++   + +            ++ll  + al+++ ++  +l+lD++    d ++ +l++ +lr+  s++++v+
  EFC38918.1 1032 DQLQS-LDDEDEEKSEKEVITIKPTGLETEisengenisAGTRQLLCLARALIRK-SK--ILILDEATaLCDLETDKLIQKTLREEFSSNCTVI 1121
                  66666.4444444444444433333333335567744423333333333344444.55..9999999967788999999999998777777775 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.041        37      27      58 ..     310     341 ..     303     361 .. 0.86
   2 !   13.2   0.0   5.3e-05     0.048      27      61 ..     932     966 ..     920     973 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.041
       AAA_7  27 elllknkkpvllvGptGtGKtviikdllkkld 58 
                 +l +k++  v+++G +G +K++++++ll +++
  EFC38918.1 310 NLKIKKGEFVCIIGRVGQSKSSLLSSLLGEMN 341
                 566889999*****************999887 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 5.3e-05
       AAA_7  27 elllknkkpvllvGptGtGKtviikdllkkldkek 61 
                 +l +++k  v ++G tG+GK+++i++l++  + e+
  EFC38918.1 932 NLKINAKERVSICGRTGSGKSSLIQSLMRMQEIEQ 966
                 566889999*****************998877554 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.71   6.3e+02       4      30 ..     315     341 ..     312     398 .. 0.71
   2 !   14.6   0.3   3.3e-05     0.029       9      38 ..     942     984 ..     937    1128 .. 0.65

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.71
      AAA_22   4 tagilvvtGesGtGKTtllrrlleqld 30 
                 +  +++++G +G  K+ ll  ll + +
  EFC38918.1 315 KGEFVCIIGRVGQSKSSLLSSLLGEMN 341
                 56799**************99987764 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 3.3e-05
      AAA_22   9 vvtGesGtGKTtllrrlleqldeeakaee.............e 38 
                  ++G +G+GK+ l++ l++  ++e++ +               
  EFC38918.1 942 SICGRTGSGKSSLIQSLMRMQEIEQESTIlidgidirnvpleT 984
                 69******************98887766677776665544441 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1      0.12   1.1e+02      16      39 ..     310     333 ..     304     338 .. 0.79
   2 !   13.2   0.0   6.2e-05     0.055      16      42 ..     932     958 ..     924     962 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.12
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                  ++i+  +++ ++G+ G  KS+ll
  EFC38918.1 310 NLKIKKGEFVCIIGRVGQSKSSLL 333
                 4677755599*************8 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 6.2e-05
      AAA_29  16 tieidlkgatlltGpsGsGKSTllDAi 42 
                  ++i+ k+ + + G++GsGKS+l+ ++
  EFC38918.1 932 NLKINAKERVSICGRTGSGKSSLIQSL 958
                 57788888999************9765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0       1.2   1.1e+03       2      28 ..     319     346 ..     319     369 .. 0.76
   2 ?   -1.4   0.0         3   2.7e+03      64      85 ..     422     443 ..     420     458 .. 0.84
   3 !   11.9   0.0   0.00022       0.2       2      37 ..     941     975 ..     940     989 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 1.2
                 EEEESSTTSSHHHHHHCHCT-.CCC-EE CS
         Roc   2 vvlvGdsgvGKtsllkrfved.kfseke 28 
                 v+++G  g+ K+sll++++ + +f e++
  EFC38918.1 319 VCIIGRVGQSKSSLLSSLLGEmNFIESQ 346
                 689************9998641454554 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 3
                 -SGGCTTTT-HHHHCTSCEEEE CS
         Roc  64 aGqerfrslhplylreaalail 85 
                 +Gq+   sl+++++++a++++l
  EFC38918.1 422 GGQKLRISLARCFYSNADVFLL 443
                 57777789**********9987 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 0.00022
                 EEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEE CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfsekekstigvdfl 37 
                 v ++G +g+GK+sl++++++ +  e+ +sti +d +
  EFC38918.1 941 VSICGRTGSGKSSLIQSLMRMQEIEQ-ESTILIDGI 975
                 789****************8766544.566655544 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   1.3      0.25   2.3e+02      86     151 ..     499     564 ..     476     591 .. 0.72
   2 ?   13.1   0.1   8.4e-05     0.075      23      57 ..     938     972 ..     925     977 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.25
       DUF87  86 kdkelkinpwsldpeelldlleeddkpaaavqrsvleealdqakakeekeklssdepveklleelk 151
                 + +  ++   +l+++ l+d +  ++k++ +++r++++e  +++++++++e +s +++ e+++ e +
  EFC38918.1 499 QGTFTELYQEDLNFKNLIDEFSSNNKNNQQEERDLFDEEEENIENQTSIELISHESLEEYSKIEEE 564
                 445567888899999999999998999999999999999999988888888887777776665555 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 8.4e-05
       DUF87  23 trHlAilgsTGsGKSntvavLleellekkgatili 57 
                 ++++ i g+TGsGKS ++ +L++    ++ +tili
  EFC38918.1 938 KERVSICGRTGSGKSSLIQSLMRMQEIEQESTILI 972
                 67899**************9998655466666665 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0      0.27   2.4e+02       1      50 [.     319     363 ..     319     400 .. 0.72
   2 ?   -2.6   0.1       7.9   7.1e+03      53      71 ..     514     531 ..     469     535 .. 0.70
   3 ?    8.8   0.0    0.0024       2.1       2      22 ..     942     962 ..     941    1021 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.27
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkklklkkkdsvysrnpeddfwdgYtgq 50 
                   +++ G+ g+ KS+l  +L  ++     ++++++ ++ +++++  ++Y  q
    EFC38918.1 319 VCIIGRVGQSKSSLLSSLLGEMN----FIESQDSFF-EKDSNLKYSYVAQ 363
                   6899*************666665....443333333.3444444445444 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 7.9
  RNA_helicase  53 vvidDfgqvkdeenpsdla 71 
                   ++id+f++++++ n++++ 
    EFC38918.1 514 NLIDEFSSNNKN-NQQEER 531
                   678899888877.444544 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.0024
  RNA_helicase   2 wlyGpsgeGKStlakeLakal 22 
                    ++G++g GKS+l+++L++  
    EFC38918.1 942 SICGRTGSGKSSLIQSLMRMQ 962
                   699*************88753 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00085      0.76       5      22 ..     945     962 ..     941    1005 .. 0.76
   2 ?    0.7   0.0      0.41   3.7e+02      58      74 ..    1083    1097 ..    1049    1124 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00085
  Viral_helicase1   5 GvpGcGKStlirkllrts 22 
                      G  G+GKS+li++l+r++
       EFC38918.1 945 GRTGSGKSSLIQSLMRMQ 962
                      778*************94 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.41
  Viral_helicase1   58 vkstkgkililDEylll 74  
                       ++  k+kililDE+++l
       EFC38918.1 1083 IR--KSKILILDEATAL 1097
                       33..59********987 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       3.8   3.4e+03      15      60 ..     293     337 ..     282     339 .. 0.75
   2 ?   11.2   0.0   0.00019      0.17      41      60 ..     940     959 ..     912     975 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.8
                   --TTEEEEEEETTS-EEEEEGGGS-.SEEEE--TTSSHHHHHHHHH CS
  FtsK_SpoIIIE  15 ssqlpvalgkeisgnplvldlkkmashllvaGatgsGKStalntLi 60 
                   +++l+    + i+ + + l +kk +  + ++G+ g  KS  l +L+
    EFC38918.1 293 WDSLKCESSPTITLKEINLKIKKGE-FVCIIGRVGQSKSSLLSSLL 337
                   4556666666666677777888888.999***********999986 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00019
                   SEEEE--TTSSHHHHHHHHH CS
  FtsK_SpoIIIE  41 hllvaGatgsGKStalntLi 60 
                    + ++G+tgsGKS  +++L+
    EFC38918.1 940 RVSICGRTGSGKSSLIQSLM 959
                   567**********9999887 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       2.2     2e+03       7      83 ..     324     367 ..     318     386 .. 0.52
   2 ?   -0.8   0.5       1.2     1e+03     100     156 ..     528     584 ..     503     594 .. 0.73
   3 ?    7.9   0.0    0.0027       2.5       4      42 ..     943     977 ..     941     987 .. 0.70
   4 ?    5.8   0.1     0.011        10     188     265 ..    1030    1093 ..     998    1093 .. 0.68

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.2
      AAA_21   7 pNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldlydpeipfefeieeflsqgvryryglrlersqv 83 
                 + g  KS+LL  l                                  +   +e +++ f++++++ +y++   +s++
  EFC38918.1 324 RVGQSKSSLLSSL--------------------------------LGEMNFIESQDS-FFEKDSNLKYSYVAQDSWI 367
                 4444444444444................................333333444444.5555555555555555555 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.2
      AAA_21 100 ldkrsleeedvfnpeargirggvsvfslkelsvsepndlqfgkaltditsrawslll 156
                 + +r+l++e + n e +++ +++s++sl e s++e++ ++++++l++ ++ + ++  
  EFC38918.1 528 QEERDLFDEEEENIENQTSIELISHESLEEYSKIEEEQRKNPSTLDSMKRLFKFAVG 584
                 367788888888888888888888888888888888888888888777766666555 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.0027
      AAA_21   4 liGpNgsGKSnLLdaldllarldrdvegltdelsggggi 42 
                 + G+ gsGKS+L++ l  ++    ++e++ ++l +g +i
  EFC38918.1 943 ICGRTGSGKSSLIQSLMRMQ----EIEQESTILIDGIDI 977
                 78**************6664....444444444444444 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.011
      AAA_21  188 lvrslklveielsdlgegeeliasvderlrer...gvvflengdgqelparel..SdGtkrllalltallralkkgsllliDE 265 
                   +++l+  ++e++                  +    +++   g   e++ + +  S Gt++ll+l+ al+r     ++l++DE
  EFC38918.1 1030 KLDQLQSLDDEDEEK----------------SekeVITIKPTGLETEISENGEniSAGTRQLLCLARALIRKS---KILILDE 1093
                  333333333333333................244477777777777777777788***************977...99****9 PP

>> IstB_IS21  IstB-like ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.6   1.4e+03      44      67 ..     313     336 ..     284     349 .. 0.82
   2 ?   -0.3   0.1      0.84   7.6e+02      95     162 ..     498     566 ..     469     576 .. 0.72
   3 ?    7.7   0.0    0.0029       2.6      44      75 ..     935     967 ..     905     975 .. 0.74
   4 ?   -1.8   0.0       2.6   2.3e+03     106     144 ..    1083    1120 ..    1072    1130 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.6
   IstB_IS21  44 iekkenivllGpsGvGKshlaial 67 
                 i+k e ++++G  G  Ks l  +l
  EFC38918.1 313 IKKGEFVCIIGRVGQSKSSLLSSL 336
                 789999***********9886654 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.84
   IstB_IS21  95 rdgklaralkrllkvdllilDdlgllpl.dqaeaellfeviekrye.rrsiiitsnlpfaewdevlgdat 162
                 ++g +++  ++ l+++ l +D+++ ++  +q+e+++lf+  e+  e ++si + s  +++e++++ +++ 
  EFC38918.1 498 QQGTFTELYQEDLNFKNL-IDEFSSNNKnNQQEERDLFDEEEENIEnQTSIELISHESLEEYSKIEEEQR 566
                 566666666666666655.588876654167788899999888887256888999999999998876665 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0029
   IstB_IS21  44 iekkenivllGpsGvGKshlaialg.veavrag 75 
                 i++ke + ++G +G GKs l  +l  ++ ++++
  EFC38918.1 935 INAKERVSICGRTGSGKSSLIQSLMrMQEIEQE 967
                 8999***************99887415566655 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 2.6
   IstB_IS21  106 llkvdllilDdlgllpldqaeaellfeviekryerrsii 144 
                  + k+++lilD+   l  d +  +l+ + + + +  + ++
  EFC38918.1 1083 IRKSKILILDEATAL-CDLETDKLIQKTLREEFSSNCTV 1120
                  45679*****97543.44444555555555555555555 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.25   2.3e+02      14      59 ..     469     522 ..     457     568 .. 0.75
   2 ?    7.5   0.2    0.0034       3.1       3      89 ..     939    1109 ..     937    1118 .. 0.66

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.25
      AAA_24  14 GKTtlakelgpkplfidtekGlksldadkfpdie..........swedfldevvel 59 
                 GKTtl+ ++  ++ fid  +    +d  ++++            ++++++de+ ++
  EFC38918.1 469 GKTTLMVTN--QIHFIDKADRILVMDQGRIVQQGtftelyqedlNFKNLIDEFSSN 522
                 9******99..999999999999999999986666666666666666666666666 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0034
      AAA_24    3 lkiliyGpsgiGKTtlakelgpkplfidtekGlksldadkfpdie............................................swedflde 55  
                   ++ i G  g+GK++l+ +l  +   i  e  +  +d++++ +++                                            +++d ld+
  EFC38918.1  939 ERVSICGRTGSGKSSLIQSL-MRMQEIEQES-TILIDGIDIRNVPletlrstmciipqqptlfkgtlrenldsysqytdrelwdalekvGMKDKLDQ 1033
                  68899***************.5555555554.33555555555555545454444444444444433333333333336666665555544444455 PP

      AAA_24   56 vvel..........................................aaeladyktlviDtideleelclaevirqn 89  
                  +++l                                          +a  ++ k+l++D ++ l++l ++ +i+++
  EFC38918.1 1034 LQSLddedeeksekevitikptgleteisengenisagtrqllclaRALIRKSKILILDEATALCDLETDKLIQKT 1109
                  4444888888888888888888888888888888888888888888888888888888888888888888888876 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.93   8.3e+02       3      21 ..     319     337 ..     317     342 .. 0.88
   2 ?    7.7   0.0    0.0035       3.2       3      22 ..     941     960 ..     939     972 .. 0.88
   3 ?   -1.2   0.1       1.9   1.7e+03      59     123 ..    1062    1120 ..    1034    1128 .. 0.59

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.93
                 EEEEC-TTTCHHHHHHHHH CS
       NACHT   3 vilqGeaGsGKTtLlqkla 21 
                 v++ G+ G+ K+ Ll +l 
  EFC38918.1 319 VCIIGRVGQSKSSLLSSLL 337
                 89*************9986 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0035
                 EEEEC-TTTCHHHHHHHHHH CS
       NACHT   3 vilqGeaGsGKTtLlqklal 22 
                 v + G+ GsGK+ L+q+l++
  EFC38918.1 941 VSICGRTGSGKSSLIQSLMR 960
                 6789**************96 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.9
                  CCCCTS--SSS-CCHHHHCCSCCCEE.....EEEE-STT-SS-TCH.........HHHHHCTTTTT--EE CS
       NACHT   59 fsqlpepaapvsevwavllelperlL.....lilDglDelvtdlgqkekqpvrtlLselirkkllpeasl 123 
                   +++  ++a  ++    ll l++ l      lilD +  l++ l+       ++l+++ +r++  +++++
  EFC38918.1 1062 SENGENISAGTRQ----LLCLARALIrkskiLILDEATALCD-LET------DKLIQKTLREEFSSNCTV 1120
                  4444444444444....2222222225555599998888887.333......578888887754444444 PP

>> TrwB_AAD_bind  Type IV secretion-system coupling protein DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.1   2.8e+03      18      39 ..     319     340 ..     314     342 .. 0.89
   2 ?   -3.1   0.2       3.1   2.8e+03      16      52 ..     456     494 ..     453     510 .. 0.64
   3 ?   10.0   0.1   0.00033       0.3       5      50 ..     929     973 ..     925     975 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.1
  TrwB_AAD_bind  18 ilivGttGsGKtqalekllrai 39 
                    + i+G +G  K+  l++ll ++
     EFC38918.1 319 VCIIGRVGQSKSSLLSSLLGEM 340
                    679***************9876 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.1
  TrwB_AAD_bind  16 qhilivGttG..sGKtqalekllrairargdraivlDlt 52 
                     hi+  G  G   GKt+ +     +   ++dr++v+D++
     EFC38918.1 456 DHIMKYGIYGflKGKTTLMVTNQIHFIDKADRILVMDQG 494
                    5888888888445888766554444557899*****963 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00033
  TrwB_AAD_bind   5 agvplpkeretqhilivGttGsGKtqalekllrairargdraivlD 50 
                     g+ l+ ++  + + i G tGsGK+  +++l+r  +  ++  i +D
     EFC38918.1 929 KGINLKINAK-ERVSICGRTGSGKSSLIQSLMRMQEIEQESTILID 973
                    5666666554.5689******************9999999999988 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1         9     8e+03      35      61 ..     249     276 ..     239     307 .. 0.56
   2 ?    4.1   3.2     0.047        42       1     109 [.     319     446 ..     319     604 .. 0.76
   3 ?    8.4   0.2    0.0022         2       1      21 [.     941     961 ..     941    1048 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 9
                 -EEEEECCT---CCS...SSEEEE.T-E CS
   Dynamin_N  35 plelqlgeeeeaseravkeelkek.ekk 61 
                   +++l ++ee+se++ + ++ke  ++k
  EFC38918.1 249 KRIIKLLSSEEISESSTDSNNKEMeNQK 276
                 4555555555544333333333332222 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.047
                 EEEEEBTTTTHHHHHHHHHTS--S---SSS---S-EEEEECCT---CCS...SSEEEE.....T-EB--CHHHHHHHHHHHHHHHTSSSS--SS..... CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlgedilprgpnptTrrplelqlgeeeeaseravkeelkek.....ekkledfsevreeieketekiagankgiskk..... 89 
                 ++++G + + KSS+l +Llge  +  ++     +   l+++   + s + ++++++e+     e + e +++v ++++ e +  +     isk+     
  EFC38918.1 319 VCIIGRVGQSKSSLLSSLLGEMNFIESQDSFFEKDSNLKYSYVAQDS-WIRNQTIRENilfgeEFDKERYQQVLHACNLEPDLQQ-----ISKEigdmt 411
                 6799*****************99999888888888888886555533.4444444444333333333334444444443333333.....333333334 PP

                 ...............-EEEEEEETTS-SEEEEE-- CS
   Dynamin_N  90 ...............villkilsllvkgltlvDlP 109
                                 i+l  +   + ++ l+D P
  EFC38918.1 412 migesginlsggqklRISLARCFYSNADVFLLDDP 446
                 44555555555555566666666666666666655 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0022
                 EEEEEBTTTTHHHHHHHHHTS CS
   Dynamin_N   1 iavvGsqSsGKSSvlnaLlge 21 
                 + ++G + sGKSS++ +L++ 
  EFC38918.1 941 VSICGRTGSGKSSLIQSLMRM 961
                 679***************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1284  (0.0716158); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.99u 0.35s 00:00:01.34 Elapsed: 00:00:00.53
# Mc/sec: 6601.41
//
Query:       EFC38919.1  [L=264]
Description: ras family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-22   80.4   0.1    1.6e-22   79.8   0.1    1.2  1  Ras           Ras family
    1.2e-10   41.7   0.0    2.3e-10   40.7   0.0    1.5  1  Roc           Ras of Complex, Roc, domain of DAPkinase
    1.2e-05   25.0   0.0      0.049   13.2   0.1    2.4  2  GTP_EFTU      Elongation factor Tu GTP binding domain
    9.8e-05   22.4   0.0    0.00019   21.5   0.0    1.6  1  MMR_HSR1      50S ribosome-binding GTPase
    0.00023   21.4   0.1       0.19   11.9   0.0    2.5  2  AAA_28        AAA domain
    0.00052   20.0   0.0       0.48   10.3   0.0    2.3  2  RsgA_GTPase   RsgA GTPase
  ------ inclusion threshold ------
      0.012   15.6   0.1       0.03   14.3   0.1    1.7  1  MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
      0.018   14.4   0.0      0.034   13.5   0.0    1.4  1  Gtr1_RagA     Gtr1/RagA G protein conserved region
      0.074   12.8   0.0          5    6.8   0.0    2.4  2  ATP_bind_1    Conserved hypothetical ATP binding protein
       0.11   12.3   0.1        1.3    8.7   0.0    2.2  2  AAA_24        AAA domain
       0.11   11.9   0.0       0.19   11.1   0.0    1.5  1  TniB          Bacterial TniB protein
       0.15   11.7   0.1         12    5.5   0.0    2.3  2  cobW          CobW/HypB/UreG, nucleotide-binding domain
       0.24   11.9   3.9       0.41   11.1   0.1    2.6  2  AAA_23        AAA domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.8   0.1   1.2e-25   1.6e-22       2     153 ..      80     245 ..      79     249 .. 0.84

  Alignments for each domain:
  == domain 1  score: 79.8 bits;  conditional E-value: 1.2e-25
                 EEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHH CS
         Ras   2 lvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrv 100
                 + ++G  + GK+sl+ +fv +kF++  ++T+ +d y+k+++vdg   +l ++DTAG + + ++r+ ++r+ ++++++ +++ +   +++++++ee+ ++
  EFC38919.1  80 VCIIGPVGNGKSSLIEQFVYGKFPQVTDPTL-EDTYRKQVKVDGFVHSLVVLDTAGLDTYIAMRDGFIRTHDCFVITASLDTTP--TKCATYYEELLDQ 175
                 789****************************.********************************************99988655..4667777777766 PP

                 ST.........TTSEEEEEEETTTGGG.G-SS-HHHHHHHH.......HHHTSEEEEEBTTTTCTHHHHH CS
         Ras 101 ae.........envpivLvGnKvDlee.kravsteegeela.......kelglkfletSAktnenveeaf 153
                  +           +piv v nK+Dl++ +r+ +++e +++        k +++  +etSAk+n nv++ +
  EFC38919.1 176 ITlikgldhdgFYFPIVFVVNKSDLQQeERESTFDEWKNYFnsfierfKFMNYDIIETSAKSNINVSKNV 245
                 66666698877569***********9866788888888877444433344445558**********9865 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.7   0.0   1.7e-13   2.3e-10       1     119 [.      79     199 ..      79     200 .. 0.72

  Alignments for each domain:
  == domain 1  score: 40.7 bits;  conditional E-value: 1.7e-13
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE.GHHH....HC CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd.srss....en 94 
                 +v+++G  g GK+sl+++fv +kf + +++t+  ++ +k+v k++g+         +l + DtaG + + ++++ ++r ++++++    +++     + 
  EFC38919.1  79 RVCIIGPVGNGKSSLIEQFVYGKFPQVTDPTLEDTY-RKQV-KVDGFV-------HSLVVLDTAGLDTYIAMRDGFIRTHDCFVITASlDTTPtkcaTY 168
                 699*****************************9877.5666.677752.......4699*************************987643333011123 PP

                 HHHHHHHHHHHCS..SS....-EEEEEE-TT CS
         Roc  95 lkeWlkelkkvag..ks....pvilvgnkiD 119
                  +e l++++   g  ++    p+++v+nk D
  EFC38919.1 169 YEELLDQITLIKGldHDgfyfPIVFVVNKSD 199
                 3444444444333212134447788888877 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00051       0.7       5      26 ..      79     100 ..      77     119 .. 0.88
   2 !   13.2   0.1   3.6e-05     0.049     123     182 ..     189     242 ..     109     248 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00051
                 EEEEEESTTSSHHHHHHHHHHH CS
    GTP_EFTU   5 nigiighvDhGKtTLtdrLlyk 26 
                  ++iig v  GK++L+++ +y 
  EFC38919.1  79 RVCIIGPVGNGKSSLIEQFVYG 100
                 58****************9986 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.6e-05
                 TEEEEEEESCGSTHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBTTTTBTHH CS
    GTP_EFTU 123 vpiivfiNKmDrlkaelkeiveevkqklsrkeeklekygekgekevpvvfgSalkgegvk 182
                  pi++++NK D  ++e + + +e k+ +   ++ +e +++ +   + ++ +Sa+++ +v+
  EFC38919.1 189 FPIVFVVNKSDLQQEERESTFDEWKNYF---NSFIERFKFMN---YDIIETSAKSNINVS 242
                 46999********************999...77777777765...799******999986 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.0   1.3e-07   0.00019       1      87 [.      79     166 ..      79     212 .. 0.67

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 1.3e-07
                 EEEEEESTTSSHHHHHHHHHTS.TEEESSSTTSSSSEEEEEEEETT..EEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT....T CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltge.kaivsdkpgtTrdinegrvklkg..keielvDtpGliegaseekglgkaflaleeadlillvvdas....e 87 
                 +v+i+G    GKS+Li + +     +v+d     +  ++ +v+  g  ++++++Dt+G ++   +   +++ f +  ++ +i   +d +     
  EFC38919.1  79 RVCIIGPVGNGKSSLIEQFVYGkFPQVTDPTLEDTYRKQVKVD--GfvHSLVVLDTAG-LD---TYIAMRDGFIRTHDCFVITASLDTTptkcA 166
                 69*****************976245665544433333444455..55689********.76...455889999988888887777775544431 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0    0.0036         5       1      19 [.      79      97 ..      79     122 .. 0.85
   2 !   11.9   0.0   0.00014      0.19      74     155 ..     126     233 ..     101     238 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0036
      AAA_28  1 kivitGgestGKTtlleaL 19
                +++i+G+ + GK++l+e++
  EFC38919.1 79 RVCIIGPVGNGKSSLIEQF 97
                79**************986 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00014
      AAA_28  74 kvlfcDrglldtlaYaraygg....................e.aeaeleaaarekrydl.vfllppap.....eidddgeRredleereaiderlreal 145
                  ++++D+  ldt++ +r  ++                    + +e+ l+++   k  d+  f++p ++     ++ + +eR+ +++e++++ + ++e +
  EFC38919.1 126 SLVVLDTAGLDTYIAMRDGFIrthdcfvitasldttptkcaTyYEELLDQITLIKGLDHdGFYFPIVFvvnksDL-QQEERESTFDEWKNYFNSFIERF 223
                 6899**************9999**************998874355567777777788888999998885554455.899999***************** PP

      AAA_28 146 relgipviiv 155
                 + +++++i+ 
  EFC38919.1 224 KFMNYDIIET 233
                 *999999987 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.0   0.00035      0.48      97     120 ..      75      98 ..      43     136 .. 0.87
   2 !    7.7   0.0    0.0022         3      48      91 ..     190     242 ..     175     256 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00035
                  CTTSEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  97 lkdktsvlvGqSGvGKStLinall 120
                  ++d  ++++G+ G GKS+Li++++
   EFC38919.1  75 VDDCRVCIIGPVGNGKSSLIEQFV 98 
                  5567789*************9876 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0022
                  EEEEEEE-GGG--HHH.........HHHHHHHHHHHTTSEEEE--TTTHTTHH CS
  RsgA_GTPase  48 epvivlnKiDlleeee.........eleelkeelealgyevllvsaktkegle 91 
                  ++v v+nK Dl +ee+          ++++ e+++ ++y+++ +sak++ +++
   EFC38919.1 190 PIVFVVNKSDLQQEERestfdewknYFNSFIERFKFMNYDIIETSAKSNINVS 242
                  57889********999999998888888999999999******9999876654 PP

>> MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.1   2.2e-05      0.03      41      81 ..     174     214 ..     153     244 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.2e-05
  MMR_HSR1_Xtn  41 tvDdlidviegnrvYipclyvlNKiDlisleeldelarepn 81 
                   ++  li  + ++  Y p ++v+NK Dl ++e  +++++ +n
    EFC38919.1 174 DQITLIKGLDHDGFYFPIVFVVNKSDLQQEERESTFDEWKN 214
                   4556899999999**************99998888877533 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   2.5e-05     0.034       2     159 ..      80     235 ..      79     239 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.5e-05
   Gtr1_RagA   2 vLLmGksgsGKts.mrsiiFdnylardtlrlgatidveksevrflgnl.tlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletl 98 
                 v ++G+ g GK+s +++ ++ ++      +l+ t +   ++v++ g++  l ++D  G +++++     +     +++ v+   +D + +++ +  e+l
  EFC38919.1  80 VCIIGPVGNGKSSlIEQFVYGKFPQVTDPTLEDTYR---KQVKVDGFVhSLVVLDTAGLDTYIAMR---DGFIRTHDCFVITASLDTTPTKCATYYEEL 172
                 6789********945679999999998899998875...67888999867999*******999884...444555678888888999988888888888 PP

   Gtr1_RagA  99 keilealrqyspe...akvfvlihKmDliqedereeifeerkeeireeieklekeeiqffaTSi 159
                  + ++ ++  + +     +   ++K Dl q++ere++f+e k+  ++ ie++++ + ++  TS 
  EFC38919.1 173 LDQITLIKGLDHDgfyFPIVFVVNKSDL-QQEERESTFDEWKNYFNSFIERFKFMNYDIIETSA 235
                 8888888888877222445566899997.5889********************99999999996 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.0     0.033        46       1      16 [.      82      97 ..      82     108 .. 0.91
   2 ?    6.8   0.0    0.0037         5     157     206 ..     189     243 ..     160     261 .. 0.69

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.033
  ATP_bind_1  1 vvGpaGsGKttfvgal 16
                ++Gp+G GK+++++++
  EFC38919.1 82 IIGPVGNGKSSLIEQF 97
                79**********9986 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0037
  ATP_bind_1 157 lPhvvvlnkfDllkeklekeleffed.vealslllekee....ekykklaeaiae 206
                  P v v+nk Dl +e++e  ++  ++ ++++ +  +  +    e  +k++ ++++
  EFC38919.1 189 FPIVFVVNKSDLQQEERESTFDEWKNyFNSFIERFKFMNydiiETSAKSNINVSK 243
                 699*********9988777766554312333222222223334555555555555 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0   0.00093       1.3       4      23 ..      79     100 ..      76     179 .. 0.87
   2 ?    1.5   0.0      0.15   2.1e+02      99     130 ..     204     235 ..     192     250 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00093
      AAA_24   4 kiliyGpsgiGKTtlakel..g 23 
                 +++i+Gp g GK++l+ ++  g
  EFC38919.1  79 RVCIIGPVGNGKSSLIEQFvyG 100
                 89***************99553 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.15
      AAA_24  99 gdgkGygelaeefrrllkklqelrknvifiah 130
                  + + ++e+++ f++++++++ +++++i ++ 
  EFC38919.1 204 ERESTFDEWKNYFNSFIERFKFMNYDIIETSA 235
                 3334599*****************99998765 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00014      0.19      37      62 ..      79     104 ..      40     121 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00014
        TniB  37 nlllvGdsnnGKtmivekFarlhppe 62 
                  + ++G+  nGK++++e+F   + p+
  EFC38919.1  79 RVCIIGPVGNGKSSLIEQFVYGKFPQ 104
                 4789***************9877544 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0    0.0085        12       4      21 ..      81      98 ..      78     107 .. 0.86
   2 ?    4.3   0.0     0.019        26     127     164 ..     175     211 ..     101     225 .. 0.69

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0085
                EEEESTTCCHHHHHHHHH CS
        cobW  4 vltGflGsGKTtLlnhll 21
                 + G++G GK++L+++ +
  EFC38919.1 81 CIIGPVGNGKSSLIEQFV 98
                689***********9876 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.019
                 CHCCHHHHHHHHHHTSSEEEEE-HHHHCHC..HHHHHH CS
        cobW 127 eeekieekaedqlaaadllvlnKtDlldeealleklee 164
                 + + i+ + +d++ +  ++v+nK Dl +ee++ ++++e
  EFC38919.1 175 QITLIKGLDHDGFYFPIVFVVNKSDLQQEERE-STFDE 211
                 5555666667788888899********99954.45444 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.7       1.2   1.6e+03     143     171 ..      22      50 ..       3      74 .. 0.50
   2 ?   11.1   0.1    0.0003      0.41      23     161 ..      81     218 ..      79     237 .. 0.63

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.2
      AAA_23 143 feefelkdkkerleelekeleeledekkl 171
                 f++ +l d++   ++++k l+e+e+ + +
  EFC38919.1  22 FWKSLLLDEFGMNNQFIKLLDEQEENDLK 50 
                 33333333333333333333333333222 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.0003
      AAA_23  23 lItGpNGaGKTTildAiklaLygetprlsrks.......grgfeksdveiesegkvkayvelt..fenkdgrytrsiererelskkkgkttkkaklell 112
                 +I+Gp G GK+++++ + ++ + ++++   ++         gf++s v + + +  ++y+ ++  f ++++     i+ +  ++ +k           +
  EFC38919.1  81 CIIGPVGNGKSSLIEQFVYGKFPQVTDPTLEDtyrkqvkVDGFVHSLVVLDT-AGLDTYIAMRdgFIRTHD--CFVITASLDTTPTK---------CAT 167
                 8**************9998888777443333344444432244444444433.466666555533433333..22222222222222.........234 PP

      AAA_23 113 eideleqfisellgskkiil..nlilflgqerfeefelkdkkerleeleke 161
                 + +el ++i+ + g + + +  ++++   +++ + +e+++++++++++ ++
  EFC38919.1 168 YYEELLDQITLIKGLDHDGFyfPIVFVVNKSDLQQEERESTFDEWKNYFNS 218
                 557777888877778877444488888888888888888888888888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (264 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       868  (0.0484132); expected 358.6 (0.02)
Passed bias filter:                      593  (0.0330749); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 1472.90
//
Query:       EFC38920.1  [L=341]
Description: hypothetical protein NAEGRDRAFT_81428 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2867  (0.159909); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.24s 00:00:00.78 Elapsed: 00:00:00.41
# Mc/sec: 2513.87
//
Query:       EFC38921.1  [L=534]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (534 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       700  (0.0390429); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3182.73
//
Query:       EFC38922.1  [L=749]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0047   16.9   0.1      0.029   14.3   0.1    2.1  1  ATPase_2  ATPase domain predominantly from Archaea
     0.0064   16.8   0.0       0.44   10.8   0.0    2.8  2  AAA_22    AAA domain
     0.0072   16.7   0.0      0.016   15.6   0.0    1.7  1  AAA_16    AAA ATPase domain


Domain annotation for each model (and alignments):
>> ATPase_2  ATPase domain predominantly from Archaea
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.1   4.8e-06     0.029      30     204 ..      97     333 ..      95     359 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 4.8e-06
    ATPase_2  30 gsGKtaLlkeiienledkdkyviyyialreesiskldefie.........eeeekkklekal..................................... 82 
                 gsGKt+Ll+e+ + l++ ++   +    +e s++ +++ ++                   a+                                     
  EFC38922.1  97 GSGKTRLLREFRQALKERNDLEQFTCCESETSSAVANNIMQavlvdmplnR---------ATltnsiekdlqfplggisrlfllrlktsieehaaiskd 186
                 89******************9999999999998888888885555544432.........444444466669999************************ PP

    ATPase_2  83 .................giavpkaeleeilk.eksklvfkaielllekikkkgkk.iiiiiDelqklidlglngaellvkeLlnliesltkekh..lcv 160
                                   + v   ++ee  +  +     + + ++l+  ++++   i i+iDe+ +l + + +g+ ++v+   ++i+  + +    + +
  EFC38922.1 187 plvsktmnvlryvgactYNHVSDLSFEEK-DiITELSFCSDWMQFLQFYSRNRLYpILILIDEASYLEYHYKDGHVSFVYLWEKVIKPTMGSSSpgIYF 284
                 *********88888777555555555544.234555566889999999999988867789********99999999***99999998877665422789 PP

    ATPase_2 161 viclsSeglfie...rvyneselegrhky..ilvddldketalnflkeg 204
                 v c++S +l+     ++ ne +l+   +   i+++ l+ e++++++++ 
  EFC38922.1 285 VACGTSSTLTKLgrgLLRNETKLISPTNAihITLEMLKEEHIMEIFEKV 333
                 9*****9999766668888888887544323888888888888887775 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.0   7.3e-05      0.44      15      64 ..      97     139 ..      90     160 .. 0.72
   2 ?    2.5   0.0     0.028   1.7e+02      87     115 ..     235     267 ..     211     301 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 7.3e-05
      AAA_22  15 GtGKTtllrrlleqldeeakaeeerpevvfvtlpsstsskdllrellral 64 
                 G+GKT+llr++++ l+e       r ++  +t+ +s++s+ +++++ +a+
  EFC38922.1  97 GSGKTRLLREFRQALKE-------RNDLEQFTCCESETSSAVANNIMQAV 139
                 9**************87.......56666566666665666666665555 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.028
      AAA_22  87 rarav.ielliiDEaqhlr...seealeeLrsl 115
                 ++ +  + l++iDEa +l    ++ +++++  +
  EFC38922.1 235 SRNRLyPILILIDEASYLEyhyKDGHVSFVYLW 267
                 33344689*********9654436666555544 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   2.7e-06     0.016      25     144 ..      88     249 ..      62     258 .. 0.60

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.7e-06
      AAA_16  25 elvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawrekleeala................. 106
                  l +ls + G+GK++l+re+++al++++     ++++ +es+       +a  ++ +++++l +    +++     +e+ l+                 
  EFC38922.1  88 LLPILSQHYGSGKTRLLREFRQALKERN---DLEQFTCCESE-----TSSAV-ANNIMQAVLVD-MPLNRATLTNSIEKDLQfplggisrlfllrlkts 176
                 555666778************9999994...22222222222.....22333.22333333333.2223444444444444444445555555555555 PP

      AAA_16 107 .............................avpelagaea.....srllellkrllallsrder..plvlvlDdl 144
                                               v++l+ +e+      +++  + ++l+++sr  r  p+++++D++
  EFC38922.1 177 ieehaaiskdplvsktmnvlryvgactynHVSDLSFEEKdiiteLSFCSDWMQFLQFYSR-NRlyPILILIDEA 249
                 555666777777777777888888888887777777777778888999999999966666.4434788888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (749 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.71u 0.35s 00:00:01.06 Elapsed: 00:00:00.51
# Mc/sec: 4430.16
//
Query:       EFC38923.1  [L=517]
Description: RGS domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.3e-21   76.3   5.2    2.3e-21   76.3   5.2    2.3  3  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
       0.14   11.8   0.1        1.3    8.7   0.0    2.2  2  CybS      CybS, succinate dehydrogenase cytochrome B small su


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.3   5.2   2.6e-25   2.3e-21       2     118 .]      24     149 ..      23     149 .. 0.97
   2 ?   -2.7   0.1      0.79   7.1e+03      61      83 ..     215     237 ..     213     258 .. 0.60
   3 ?   -2.0   0.0      0.46   4.1e+03      47      78 ..     411     442 ..     388     456 .. 0.71

  Alignments for each domain:
  == domain 1  score: 76.3 bits;  conditional E-value: 2.6e-25
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.........STTTTTTH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke.........qpsrklfe 91 
                 le +++ +  ++ Fr +l++e++ee l F+++ve+fk+ k +e+ +kka  I+++y++p+s++e+ni+++ r+++   +ek+           ++++f+
  EFC38923.1  24 LEAIFDVPEAKEEFRAYLKREHNEEPLLFYEEVEDFKRLKFEENKTKKALFILKTYVMPNSSHEINISSQYRQNIVLGFEKSgqltseknmLVDETIFD 122
                 6778999999******************************************************************************9998999**** PP

                 HHHHHHHHHHHHHHHHHHHTSHHHHHH CS
         RGS  92 eaqeevfellekdsypkFlkselylrl 118
                 + q+++f  l++d yp+F ks  ++++
  EFC38923.1 123 DSQSAIFYNLKNDTYPRFTKSVQFNNF 149
                 **********************99976 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.79
                 TSTTSSTS-HHHHHHHHHHHCSS CS
         RGS  61 sspkelnidkklreelekrleke 83 
                 +s+ke nid++  +   k l+++
  EFC38923.1 215 QSKKEFNIDENEEKANGKLLKQV 237
                 57888888888766655555554 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.46
                 HHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHH CS
         RGS  47 kkkakeIyneylapsspkelnidkklreelek 78 
                  +++k+I   y++ +s ++ +i kk ++  +k
  EFC38923.1 411 ENACKVICVSYIDLQSMQSDFIRKKFFNAKNK 442
                 56677777888877777777777776665444 PP

>> CybS  CybS, succinate dehydrogenase cytochrome B small subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0     0.065   5.8e+02      84     111 ..     269     296 ..     265     298 .. 0.86
   2 ?    8.7   0.0   0.00014       1.3      69     103 ..     414     448 ..     412     473 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.065
        CybS  84 iDYipkrvygklhklahylLalgtvlsl 111
                 +DYip ++ +k+++    ++  +t+l+ 
  EFC38923.1 269 LDYIPISKTNKYAQSILKIVIQMTGLTW 296
                 6******999999999998888888875 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00014
        CybS  69 vlllihshlgfesciiDYipkrvygklhklahylL 103
                 + +++ s+++++s+  D+i+k+ +++ +k+ah + 
  EFC38923.1 414 CKVICVSYIDLQSMQSDFIRKKFFNAKNKAAHTVF 448
                 5678889***********************99874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.25s 00:00:00.88 Elapsed: 00:00:00.47
# Mc/sec: 3318.51
//
Query:       EFC38924.1  [L=146]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       539  (0.030063); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.53
# Mc/sec: 834.26
//
Query:       EFC38925.1  [L=648]
Description: hypothetical protein NAEGRDRAFT_73187 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   7.2e-261  866.6   8.7   8.3e-261  866.4   8.7    1.0  1  HSP70           Hsp70 protein
    1.8e-18   66.5   5.0    3.9e-17   62.1   0.0    3.0  3  MreB_Mbl        MreB/Mbl protein
     0.0048   16.2   0.1      0.031   13.5   0.1    2.1  2  Hydantoinase_A  Hydantoinase/oxoprolinase
  ------ inclusion threshold ------
      0.033   14.6   0.7         12    6.4   0.0    3.4  3  FtsA            Cell division protein FtsA
      0.034   13.1   1.3       0.46    9.4   0.1    2.6  3  DDR             Diol dehydratase reactivase ATPase-like domai
      0.068   12.6   0.0          4    6.8   0.0    2.4  2  BcrAD_BadFG     BadF/BadG/BcrA/BcrD ATPase family
       0.95    8.7   5.8        3.8    6.7   2.5    2.4  2  EAP30           EAP30/Vps36 family
        1.5    9.1   6.0         14    5.9   1.6    2.8  2  Cys_rich_FGFR   Cysteine rich repeat
        3.4    7.7   7.5        6.7    6.8   7.5    1.4  1  UPF0242         Uncharacterised protein family (UPF0242) N-te
        4.8    7.2  12.1        2.4    8.2   9.0    2.1  3  Erp_C           Erp protein C-terminus


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  866.4   8.7  4.6e-264  8.3e-261       1     599 []      10     611 ..      10     611 .. 0.98

  Alignments for each domain:
  == domain 1  score: 866.4 bits;  conditional E-value: 4.6e-264
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXTTSEEETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHHHTTXSSEEEEETTSBEEE CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrttPsvvaFtkkerlvGeaAkrqavtnpkntvfsvKrliGrkfsdpevqkeikelpykvvkkengkavv 99 
                 +iGiDLGtt+s+v+v  g+++e+i n++gnrttPs+vaFt++erl+G+aAk+q+++np+ntvf++KrliGrkfsd++vq ++k++p+kv +k+++k+++
  EFC38925.1  10 AIGIDLGTTYSCVGVYMGDNVEIIPNDQGNRTTPSYVAFTDEERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFSDSTVQDDMKHWPFKVITKSDEKPYI 108
                 59************************************************************************************************* PP

                 EEEETTE..EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSSSCEEEEEEEEXSS CS
       HSP70 100 eveaage..kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkdkernvlvyDlGgg 196
                 +ve++ge   ftpeqis+mvL+k+k++ e+ylgk+v++avitvPaYfnd+qRqatkdAg+iAGL+vlRi+NepTAaa+aYGl+kk  ernvl++DlGgg
  EFC38925.1 109 QVEYKGEshVFTPEQISSMVLTKMKDISEQYLGKQVKKAVITVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKG-ERNVLIFDLGGG 206
                 *******999***************************************************************************9.************ PP

                 XEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTEEEEEEEEH CS
       HSP70 197 tfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrlkeaaekaKkeLSsskqteinleietvdedgkdlseklsR 295
                 tfdvSil++e+GvfevkaTagDthlGGedfD+ +v+++++efk+k++ d++++++al+rl++a+e+aK++LSs  +++++++++++++ g dl+++++R
  EFC38925.1 207 TFDVSILNIEDGVFEVKATAGDTHLGGEDFDNLMVQFCCQEFKRKYKKDIQENPRALRRLRTACERAKRNLSS--AANASINVDSIMD-GIDLDISMTR 302
                 *************************************************************************..899999******9.********** PP

                 HHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTT.CHHBSSSHTTTHHHHHHHHHHHHHCTCGCSHCCEEEEBESS- CS
       HSP70 296 akfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfg.kepsktvnpDeavaiGAAvqagvlsgeeevkdllllDvtpLs 393
                 akfe+l++dl++++ epv+k+l+d++l+k +id+vvlvGGstRiPkvqe+++e+f+ ke+++++npDeava+GAAvq+gvl+g  + +++ll DvtpLs
  EFC38925.1 303 AKFEQLNMDLFKKCFEPVKKVLQDSGLDKAQIDDVVLVGGSTRIPKVQEMLREFFNgKELCRSINPDEAVAYGAAVQGGVLTG--KETKVLLIDVTPLS 399
                 *******************************************************99**************************..9999********** PP

                 EEEEETTTEEEEEESTTCBSSEEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEEEEETTTCCEE CS
       HSP70 394 lgietlggvmtkliernttiptkksqvfstaadnqtaveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvsakdketgkee 492
                 lgiet+ggvmtkliern tip kks++fst+adnqtav+i+v++ger+l+kdn+llg+f+l+gippaprGvp+ieVtf+id nGi++vsakd+++gk++
  EFC38925.1 400 LGIETAGGVMTKLIERNSTIPCKKSEIFSTYADNQTAVTIQVFEGERTLTKDNHLLGRFNLEGIPPAPRGVPKIEVTFEIDSNGIMKVSAKDTSSGKTQ 498
                 *************************************************************************************************** PP

                 EEEEECCSS.SBHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..GGGSTHHHH....HHHHHHHHHHHCHTTSSCHHHHHHHHH CS
       HSP70 493 eitieaseg.lseeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleee..aekvseaek....ekvesaieeLkeeleeeekeeieakte 584
                 +iti++++g ls+eeie+mvk+a+e+++ dk+ ke+i+akn++e+++y+++++ ++   + k+s+a+k    ++ e+ i++L+++ ++ +k++ie+k++
  EFC38925.1 499 NITIKNEQGrLSKEEIEEMVKKAKEMEQFDKELKEKIDAKNQLEAYAYQTKSTADDPnlSGKLSDADKntikKTCEEVINWLDNN-STYSKDDIEKKRK 596
                 *********9********************************************9988999*******55555555666666666.45669******** PP

                 HHHHHHHHHHHHHHH CS
       HSP70 585 elkkvvekiaeklye 599
                 el+  + +i++kly+
  EFC38925.1 597 ELEGKCAPIVSKLYQ 611
                 **********99986 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.028        50       3      50 ..      10      63 ..       8      80 .. 0.64
   2 !   62.1   0.0   2.2e-20   3.9e-17      76     316 ..     126     377 ..     118     384 .. 0.81
   3 ?    2.0   0.8      0.04        71     212     271 ..     477     534 ..     470     539 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.028
                EEEEEE-SSEEEE..EETTTEEEE.......EEES-EEEETTT--EEEESHHHHTTT CS
    MreB_Mbl  3 dlgiDLGtantlv..yvkgkgivl.......nepsvvAikkktkkvlavGeeAkkml 50
                 +giDLGt+   v  y+ ++  ++       + ps vA++ +++    +G+ Ak+ +
  EFC38925.1 10 AIGIDLGTTYSCVgvYMGDNVEIIpndqgnrTTPSYVAFTDEER---LIGDAAKNQV 63
                69******998865588887655522222222477777765544...3466666555 PP

  == domain 2  score: 62.1 bits;  conditional E-value: 2.2e-20
                 HHHHHHHHHHHTSS-S.S--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-EEEEEEETTEEE..... CS
    MreB_Mbl  76 ellkyfikkvkkkksl.skprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglpveepsgnmvvdiGggttevavislggiv..... 168
                 +++ + +k+++++    + ++ vi+vP   ++ +r+A k+a   aG +   +i+ep aAAi  gl+ +  +  ++ d+Gggt +v+++ + + v     
  EFC38925.1 126 SMVLTKMKDISEQYLGkQVKKAVITVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKGERNVLIFDLGGGTFDVSILNIEDGVfevka 224
                 5555666666665443256789*******************************************************************9987622222 PP

                 EEEEES-SHHHHHHHHHHHH....HHHHSEE--HH..HHHHHHHHH-BSS--HHHH.EEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHHHHH CS
    MreB_Mbl 169 tsksvrvaGdeldeaiikyi....rkkynlliGer..taekikieigsavkeeeee.kmeikGrdlvtglpkevevsseevrealkepvsaiveavkev 260
                 t+   +++G+++d+ ++++     ++ky+  i e+    ++++++   a+ + ++  + +i+   ++ g+   ++++ ++ ++   + +++  e vk+v
  EFC38925.1 225 TAGDTHLGGEDFDNLMVQFCcqefKRKYKKDIQENprALRRLRTACERAKRNLSSAaNASINVDSIMDGIDLDISMTRAKFEQLNMDLFKKCFEPVKKV 323
                 2345789**********9963333788888888751144566666666655544447999*************************************** PP

                 HHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS-.EEE-SSTTTHHHHHHH CS
    MreB_Mbl 261 LektppeLaadivdrgivltGGgallkgldkllseetglp.vkvaedpltcvakGtg 316
                 L++   + a   +d  +vl+GG++ +  ++++l+e ++ +    + +p ++va G++
  EFC38925.1 324 LQDSGLDKA-Q-ID-DVVLVGGSTRIPKVQEMLREFFNGKeLCRSINPDEAVAYGAA 377
                 **9876643.3.44.58999***************9876515567789999999875 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.04
                 S--HHHHEEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHTS-HHHHHH CS
    MreB_Mbl 212 vkeeeeekmeikGrdlvtglpkevevsseevrealkepvsaiveavkevLektppeLaad 271
                 ++ +++  m+++ +d  +g  +++++++e+ r   ke+++++v+++ke +e+   eL   
  EFC38925.1 477 FEIDSNGIMKVSAKDTSSGKTQNITIKNEQGR-LSKEEIEEMVKKAKE-MEQFDKELKEK 534
                 555666789******************99866.457888999988876.57777777665 PP

>> Hydantoinase_A  Hydantoinase/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.1   1.7e-05     0.031      24     103 ..     142     222 ..     124     231 .. 0.71
   2 ?   -0.5   0.0      0.33   5.9e+02     225     282 ..     316     376 ..     299     379 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.7e-05
  Hydantoinase_A  24 kslekrgakarlmvmqsdGglv.sadearkkpvetilSGPaaGvvgaaatsklagekkvItfDmGGTstDvsl..ikdgevev 103
                     k+++k+ ++ + ++ +s+   + +a ++ +  v  i+  P a ++++    +++ge++v+ fD+GG ++Dvs   i+dg +ev
      EFC38925.1 142 KQVKKAVITVPAYFNDSQRQATkDAGAIAGLEVLRIINEPTAAAIAYGL--NKKGERNVLIFDLGGGTFDVSIlnIEDGVFEV 222
                     5555555556666666665543255666666677788889888888888..99*****************9962255666655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.33
  Hydantoinase_A 225 manavrklsvergldpkeltlvvfGGaG...aqhaaalaeelgvkkvivppyagvlsalGm 282
                       ++v+k++++ gld+ +   vv  G++   + + ++l e ++ k+      +  ++a+G+
      EFC38925.1 316 CFEPVKKVLQDSGLDKAQIDDVVLVGGStriPKVQEMLREFFNGKELCRSINPDEAVAYGA 376
                     5688999*********999988876666344445555555566665555555555555555 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0064        12       1      32 [.      11      40 ..      11     171 .. 0.86
   2 ?    4.5   0.0     0.025        45       4      89 ..     202     360 ..     199     379 .. 0.59
   3 ?   -0.6   0.0      0.98   1.8e+03      40      52 ..     513     525 ..     386     597 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0064
                EEEEE-SSSEEEEEEETTEEEEEEEES-.-HHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx RF
        FtsA  1 alvDiGagktdvavaedgalvhlrvigv.ggng 32
                +++D+G++ ++v v+ ++   ++++i+  +gn 
  EFC38925.1 11 IGIDLGTTYSCVGVYMGD---NVEIIPNdQGNR 40
                58***************7...888888765554 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.025
                 EE-SSSEEEEEEETTEEEE.....EEEES-....-HHHHHHH......................HHHHHT--HHHHHHHHHHH--S--........... CS
                 xxxxxxxxxxxxxxxxxxx.....xxxxxx....xxxxxxxx......................xxxxxxxxxxxxxxxxxxxxxxxx........... RF
        FtsA   4 DiGagktdvavaedgalvh.....lrvigv....ggngitkd......................iakalrtaveeAerikikyGsala........... 60 
                 D+G+g+ dv++++ +  v+               gg+ +++                       + + lrta e A+r   + +   +           
  EFC38925.1 202 DLGGGTFDVSILNIEDGVFevkatA----GdthlGGEDFDNLmvqfccqefkrkykkdiqenprALRRLRTACERAKRNLSSAA---Nasinvdsimdg 293
                 7777777777777654332333231....1223344444444555555555555666677766666777777777777773322...223355555555 PP

                 ...EEEEEHHHHH...........................................GGGGSTTHHHHHHHHHT-. CS
                 ...xxxxxxxxxx...........................................xxxxxxxxxxxxxxxxxxx RF
        FtsA  61 ...ekeigrkels...........................................ggsalpnleelaeralspk 89 
                    +                                                    g++ +p+++e++++ ++ k
  EFC38925.1 294 idlD--------IsmtrakfeqlnmdlfkkcfepvkkvlqdsgldkaqiddvvlvgGSTRIPKVQEMLREFFNGK 360
                 5441........044444455666777777777888888888888888888889999999999999999998543 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.98
                 HHT--HHHHHHHH CS
                 xxxxxxxxxxxxx RF
        FtsA  40 alrtaveeAerik 52 
                  + + v++A++++
  EFC38925.1 513 EIEEMVKKAKEME 525
                 2333333333333 PP

>> DDR  Diol dehydratase reactivase ATPase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1   0.00026      0.46     132     166 ..     195     228 ..     170     231 .. 0.81
   2 ?    1.6   0.0     0.062   1.1e+02     273     296 ..     332     355 ..     307     364 .. 0.82
   3 ?   -2.5   0.1       1.1   1.9e+03      84     111 ..     513     539 ..     483     545 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00026
         DDR 132 ekplailDlGaGstDaalieeegevkavhlAGAGe 166
                 e+++ i DlG+G+ D ++++ e+ v  v  A AG+
  EFC38925.1 195 ERNVLIFDLGGGTFDVSILNIEDGVFEVK-ATAGD 228
                 56799***************999998864.77776 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.062
         DDR 273 rdidfvvlvGgsalDfEipelvtd 296
                  +id vvlvGgs+    ++e++ +
  EFC38925.1 332 AQIDDVVLVGGSTRIPKVQEMLRE 355
                 5899********988888888766 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 1.1
         DDR  84 glaamvktdklqmqkiaeeleeelgvkv 111
                  + +mvk +  +m++  +el+e+++ k 
  EFC38925.1 513 EIEEMVK-KAKEMEQFDKELKEKIDAKN 539
                 4566774.44567777777777776665 PP

>> BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0    0.0022         4       1      50 [.      11      61 ..      11      91 .. 0.94
   2 ?    3.3   0.0     0.027        48     202     265 ..     320     378 ..     266     380 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0022
                 EEEEE-SS.EEEEEEEETTTEEEEEEEE--TTS-HHH.........HHHHH CS
  BcrAD_BadFG  1 vGiDgGsT.ttkavlmdekgevlgrgitnsanlesvrfeaaekvleealte 50
                 +GiD+G+T ++  v m ++ e++ + + n +  + v f++ e+ + +a ++
   EFC38925.1 11 IGIDLGTTySCVGVYMGDNVEIIPNDQGNRTTPSYVAFTDEERLIGDAAKN 61
                 7*******889**********************************999875 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.027
                  HHHHHHHHHHTT---SS.EEEESGGGG-HHHHHHH.....HHHH-S-EE--GGGGGHHHHHHHH CS
  BcrAD_BadFG 202 ialrvialisrsggvtdevtltGGvakneaavkelrklvkenygevkininpdsiytgalGAal 265
                  +++ +       +++ d+v+l+GG  +  + v   ++++ e +++++   ++ ++ + a GAa+
   EFC38925.1 320 VKKVLQDSGLDKAQI-DDVVLVGGSTRI-PKV---QEMLREFFNGKELCRSINPDEAVAYGAAV 378
                  444444444444445.339999999999.434...34478888888888999999999999985 PP

>> EAP30  EAP30/Vps36 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.048        87      29      67 ..     234     270 ..     226     310 .. 0.80
   2 ?    6.7   2.5    0.0021       3.8      29      61 ..     512     543 ..     483     565 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.048
       EAP30  29 qdleallakfkesLvklaekhkakiksdpafraqftkmc 67 
                 +d ++l+ +f    +++ +k+k++i+++p   ++ ++ c
  EFC38925.1 234 EDFDNLMVQFCC--QEFKRKYKKDIQENPRALRRLRTAC 270
                 577888888887..99*************9777766644 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0021
       EAP30  29 qdleallakfkesLvklaekhkakiksdpafra 61 
                 +++e++ +k+ke ++++ +++k+ki ++++ +a
  EFC38925.1 512 EEIEEMVKKAKE-MEQFDKELKEKIDAKNQLEA 543
                 689*********.**************998766 PP

>> Cys_rich_FGFR  Cysteine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   1.6    0.0079        14       3      30 ..     245     272 ..     244     275 .. 0.96
   2 ?    4.4   0.2     0.024        43      11      39 ..     548     576 ..     538     602 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0079
  Cys_rich_FGFR   3 CkqlllrlqeevaeDykldpkLqkaCkd 30 
                    C++ ++++++++ e+ ++ + L +aC++
     EFC38925.1 245 CQEFKRKYKKDIQENPRALRRLRTACER 272
                    **************************96 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.024
  Cys_rich_FGFR  11 qeevaeDykldpkLqkaCkddiekfCsdi 39 
                    ++  a+D +l+ kL++a k+ i+k C+++
     EFC38925.1 548 TKSTADDPNLSGKLSDADKNTIKKTCEEV 576
                    66778999******************874 PP

>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   7.5    0.0037       6.7      64     172 ..     496     605 ..     476     609 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0037
     UPF0242  64 klekskleekeaklteldeglktkeealeelqeeeeeLkeeldakeeelerlkeenq.....qLqekleaiaedfeelkleleeqLaekqellqeyqet 157
                 k+++ ++++++  l++++  +++  ++ +e+++  +eLke++dak+++ +   + +      +L+ kl++  +d +  k+  ee ++   +    ++  
  EFC38925.1 496 KTQNITIKNEQGRLSKEE--IEEMVKKAKEMEQFDKELKEKIDAKNQLEAYAYQTKStaddpNLSGKLSD--ADKNTIKKTCEEVINWLDNNSTYSKDD 590
                 445666666666665555..55555555555555667777777777654433333333344489999988..79999********************** PP

     UPF0242 158 ieeqrsvlekrqdqi 172
                 ie++r++le + + i
  EFC38925.1 591 IEKKRKELEGKCAPI 605
                 ********9987655 PP

>> Erp_C  Erp protein C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       6.3   1.1e+04      34      48 ..      41      55 ..      39      59 .. 0.83
   2 ?   -2.8   0.0       3.2   5.7e+03     110     125 ..     310     325 ..     254     328 .. 0.58
   3 ?    8.2   9.0    0.0013       2.4      44     131 ..     498     587 ..     478     594 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 6.3
       Erp_C 34 tgpvyddftdgnkai 48
                t p y  ftd+++ i
  EFC38925.1 41 TTPSYVAFTDEERLI 55
                7899*****998766 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.2
       Erp_C 110 leklkskleevkkylk 125
                 ++ +k  +e vkk l+
  EFC38925.1 310 MDLFKKCFEPVKKVLQ 325
                 2333444445555544 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0013
       Erp_C  44 gnkaiyktwgdledeedeglgkllkelsdtrdelrtklnegnk..ayivlekepklkenvnvseikedleklkskleevkkylkdedkfe 131
                 +n +i++  g l +ee e++ k  ke+ +  +el+ k++  n+  ay  ++k      n++      d + +k   eev ++l++++ + 
  EFC38925.1 498 QNITIKNEQGRLSKEEIEEMVKKAKEMEQFDKELKEKIDAKNQleAYAYQTKSTADDPNLSGKLSDADKNTIKKTCEEVINWLDNNSTYS 587
                 678899999******************************999743677777655544455444455677789*************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (648 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1961  (0.109376); expected 358.6 (0.02)
Passed bias filter:                      860  (0.047967); expected 358.6 (0.02)
Passed Vit filter:                        91  (0.00507558); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.87u 0.34s 00:00:01.21 Elapsed: 00:00:00.53
# Mc/sec: 3704.72
//
Query:       EFC38926.1  [L=266]
Description: GTP-binding protein EngA [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00065   19.7   0.0       0.93    9.4   0.0    2.4  2  RsgA_GTPase     RsgA GTPase
  ------ inclusion threshold ------
      0.045   13.8   0.0      0.075   13.1   0.0    1.5  1  MMR_HSR1        50S ribosome-binding GTPase
      0.074   12.2   0.0       0.78    8.9   0.0    2.1  2  Reoviridae_Vp9  Reoviridae VP9


Domain annotation for each model (and alignments):
>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00015      0.93     105     157 ..      15      71 ..       3      76 .. 0.72
   2 !    7.8   0.0   0.00049       2.9      15     100 ..     113     202 ..     101     206 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00015
                  ECSTTSSHHHHHHHHCTT....-----S--------------SEEEEEETTTEEEES CS
  RsgA_GTPase 105 vGqSGvGKStLinallpe....lelktgevseklgrGkhTTtavellelaegglliD 157
                  + +S vGKS++i ++++      e  tg   + +g   hTT +v+ ++l e+  + D
   EFC38926.1  15 LAPSNVGKSSFIMTIHSAikgmREKPTGLEVRVSGGADHTTMSVNNYPLTEKISIND 71 
                  45899*******99999733323444443333455568********99998877766 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00049
                  S--EEEEEEESTTTT--HHHHHHHHHHHHHTT-...EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TT.THTTHHHHHHHCTTS CS
  RsgA_GTPase  15 NvdqllivvslkepelslnlldrfLvlaeekgi...epvivlnKiDlleeeeeleelkeelealgyevllvsak.tkegleelkellkdk 100
                     ++++++ + e+ +++ +l+++ vl  +++     +  +++K+D + ++++++++++ +     + +l++++  k+  e+++++++++
   EFC38926.1 113 RASNAVLLMLTFEDCFTPGFLEKLKVLHDSAREmgrVVAFAITKLDTIADDTKIQQFNDSVDPETAQNFLLNSSaFKRCSERIQQVISGQ 202
                  555666666666699999999988776554433122667789***************999998777776665551466777888888776 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   1.3e-05     0.075       7      72 ..      17     112 ..      11     170 .. 0.64

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.3e-05
                 STTSSHHHHHHHHHT..........S.TEEE.SSSTTSSSSEEEEEEEETTEEEEEEECGGC...................SS.HHHHHH.HHHHHHHH CS
    MMR_HSR1   7 rpNvGKStLinaltg..........e.kaiv.sdkpgtTrdinegrvklkgkeielvDtpGl...................ie.gaseek.glgkafla 72 
                  +NvGKS++i ++              +++v +    tT  +n + ++   ++i + D+ G                    ++ g+s++  +++++ l+
  EFC38926.1  17 PSNVGKSSFIMTIHSaikgmrekptGlEVRVsGGADHTTMSVNNYPLT---EKISINDIFGWdfnsdnlqvdrfkcllegmLKfGQSKNDpSVSESDLS 112
                 68***********85455555544314667735666999999999998...589999999965555555555555543333223333333355555554 PP

>> Reoviridae_Vp9  Reoviridae VP9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.0   0.00013      0.78     214     251 ..      28      65 ..      11      86 .. 0.87
   2 ?    1.0   0.0     0.032   1.9e+02     150     180 ..     137     167 ..     128     185 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00013
                     HHTTS-GGGB----EEEE--TT---EE----SS-S--- CS
  Reoviridae_Vp9 214 lvnslleGerarvvGlyvdieGvtvstsaslsslpltt 251
                      + s ++G r +++Gl v + G +  t+ s+   plt+
      EFC38926.1  28 TIHSAIKGMREKPTGLEVRVSGGADHTTMSVNNYPLTE 65 
                     57899*******************************97 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.032
                     EETTTTCEEEEEEEEEEEEESB-TT-S---E CS
  Reoviridae_Vp9 150 islidsvvitGkvyvlfitslsttasksnsy 180
                     + l+ds  + G+v+ + it l t a+++   
      EFC38926.1 137 KVLHDSAREMGRVVAFAITKLDTIADDTKIQ 167
                     5699999**************9999888655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.35s 00:00:00.95 Elapsed: 00:00:00.55
# Mc/sec: 1459.72
//
Query:       EFC38927.1  [L=3330]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   5.8e-107  358.6  54.1    4.8e-74  249.5  31.4    2.6  2  Nup192         Nuclear pore complex scaffold, nucleoporins 18
    2.9e-47  161.3   0.4    7.1e-47  160.0   0.4    1.6  1  Pkinase        Protein kinase domain
    4.5e-36  124.5   1.7    2.5e-34  118.7   1.7    2.5  1  Pkinase_Tyr    Protein tyrosine kinase
    4.7e-22   76.8   6.8     0.0029   17.5   0.0    9.5 10  NHL            NHL repeat
    4.2e-06   26.5   0.4          2    7.9   0.0    4.7  4  SGL            SMP-30/Gluconolactonase/LRE-like region
    2.5e-05   24.6  29.8      0.016   15.6  11.2    2.7  2  EGF_2          EGF-like domain
  ------ inclusion threshold ------
      0.016   15.3   0.1        0.4   10.8   0.0    3.6  3  Str_synth      Strictosidine synthase
        4.7    7.6  17.4       0.02   15.2   3.2    2.9  2  EGF            EGF-like domain


Domain annotation for each model (and alignments):
>> Nup192  Nuclear pore complex scaffold, nucleoporins 186/192/205
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  249.5  31.4   2.1e-77   4.8e-74       5    1233 ..      11    1170 ..       8    1183 .. 0.75
   2 !  114.1  14.9   1.5e-36   3.3e-33    1317    1682 ..    1184    1559 ..    1178    1572 .. 0.80

  Alignments for each domain:
  == domain 1  score: 249.5 bits;  conditional E-value: 2.1e-77
                  HHHHHHHHHHHHHTTXTTHHHHHHHHHHTHHHHHHTTXX..XXXXHHHHHCHCC..XSEEEETTE.EEEXXHHHHHHHHHHHHHHTXXHHHHHHHHH CS
      Nup192    5 afkeLynsieaassnpesldelelllkklkqdLknllkn..ppkneksRsqlkkektgkitlsdgseyklnqefiqealiLSdeldLdElaaaeLll 99  
                  +f +Ly+ ++++s  +e+  + ++++ +l+ ++k+ ++   p k+   R+++++   +++ +++     l + + + +l++Sd l+L+El+a++L++
  EFC38927.1   11 SFHTLYERVSSLSLIKENK-DSTTKFFQLLANFKSSFQFkfPEKSSDARNKIQT---NNVDIKGV-PSTLPDSLKELVLQVSDALNLNELVALSLIF 102 
                  7999999999666664433.334556666666666655555***********87...9*******.777**************************** PP

                  HHCTHHH..HTTSXHHHHHHHHHHHHHHHHHHHHHHHHHHHT..XTTSXH...TTXXXXXX..XXXHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      Nup192  100 taqeqqan.kpglslgevAvllYydrrkyilqiLryllqvaseeeedeek...llsswste..atklvtnileslkeikqllsklkdlldkadvlke 190 
                  ta+++++    g+   + ++ l+y+ +  +l+++  l+q   +e+   ++   +  +++ e   ++++++i+e++ + ++++++ ++l+++ +  ++
  EFC38927.1  103 TATKSNPPqVYGVHEYQLSIKLFYEDYLKLLSSVLILFQSRFNEDLHPNTrdvV-VKFTNEllSDNIISSICEQITSTSKQINEAQNLITTLEQQGN 198 
                  ***99886577****************************655444333225533.345555778999999999999999999999999999999998 PP

                  HSXXTTHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXXXHHHHHHHHHH.H...........HHXXXXSHHHHHHHHHHHHHHTSSSSXXXHHHHHHH CS
      Nup192  191 iqknrflgsikfrrdlLekehelLaqilfglvaqsglekedilkllkhLa...........kkldknDdltlhllpallaafssledlsvledvrel 276 
                    + ++++s++  + +  ++++  a++lf + ++ + + + + k+++              +++++  +   + +p++++++   ++ s  +    l
  EFC38927.1  199 QDSVKVYQSSEQIKYK-VEIRRGFAECLFFACSNIQCDDDTFFKVFNTFIglqnlfnqcvaNRIGERQEEFSYSFPSIFEYLPIGTK-SIFSILYLL 293 
                  7666777777666655.4678888888888877777665555555555445557777777755655555556777777777733333.222332334 PP

                  HHHHTSSSTTSSSHH....................................................HHHHHHHHHHHHHGGGHHHHHHHHHHHH.. CS
      Nup192  277 hekitkrleeeplvsdee.......................................idlskwklkglkaaiklvflleligwckqepeertkkfdf 334 
                   ++i++ l+  p++ +                                         +        +++a+++l++ + l      +       +++
  EFC38927.1  294 TTTILSLLD--PTIGKIRidpkgvtqspnnslykqqfiekfdkildnlmpddhddlsY---LIDRTQFEAMTALQWCVGLRVQNNIK-----PNLEL 380 
                  444444442..22222220111222222233333333444444444444444332221...22334566666666666665553333.....35566 PP

                  ........HHHHHTTHHHHHHHHHHHHSXXSSXXGGGTTTTXXSXXXSXXXXSXSXXXXHHHHHHHHHHHHHHHHHHHHHXHHHHH.HHHHHHHHHH CS
      Nup192  335 kedieklieeaiedgafefllsvaaetsakewedslrydfrslLqrkiprltpeklllseefeefllrrlhtlitdfIsnmafvLt.kLRdreedsl 430 
                   ++ ++   ++++ g+f f+++ +++++   ++                         se+ +ef++  l +li++fI n+ + +  +L d+ e+ +
  EFC38927.1  381 LTRSDNAFSKSLSRGVFAFITTGLLNNK--VYRS-----------------------ESENVKEFIVNILGDLISSFIVNLEDSINdSLVDQIEELR 452 
                  689999999999*************999..2222.......................29***********************999637999999876 PP

                  ..HHXTTS.............TXXXHHHHHHHHHHHHHTTXHHHHHHHH.SXTTSHHHHHHHHHTSSXXHHH..........HHHHHHHHHTTXSSH CS
      Nup192  431 lsveslqqegleppanleediaqkadLErfllliaylYenrpelaleFW.sdkesnlygFiewassllpspl..........ikaflkMLssLssge 516 
                   s +++ +++  ++++++   +   ++   lll a+lY++ p +  ++   d + +l  F++ +   + ++l          ++ +l  L+s s  +
  EFC38927.1  453 -SYLTRRDDNQASEEDEQ---NIPREFNDILLLLAELYRGFPSYTHKYFdRDANPKLNDFLRKTCCEQITSLckfqveldvtFIYYLGVLCSFSGDS 545 
                  .66666444434444333...3489**********************99555588999999876544333331222222222667999********* PP

                  HHHHHHHHHHCXTTXSSXSSTTTBXXSHHHHHHHH.HHHHHHHXXXXXX.XXXXXXXX.........XXXSXXXHHHHHHHHHHHHHHHHHHHHXHH CS
      Nup192  517 enaraafnlLkdnsssagkkkrsssvswdhifksL.syYidklqependlklrqkkqeneesiyrsraieeeleeeeivflsaflrLissvaknsee 612 
                    a+++f lL+d+         +   sw+ +fk L +++ ++                       s++++   e++++  +s +l+L++ v++nse+
  EFC38927.1  546 VGATNVFALLNDST--------YPLFSWEYFFKVLlEEFRSQC----------------------SSNDDFVFEKRTLDAISIVLKLVEVVCRNSEQ 612 
                  ***********944........689********8625555555......................23678899************************ PP

                  HHHHHHCXTTTXHHHHHHHHHTSS.XXHHHHHHHHHHHHHTTSXXHHH.HHHHHHHHHHHHHX..XXXXXXXXX.XXXXXXXXHHHHHHHHHHHHTS CS
      Nup192  613 arkallenaswqfldvllgLlsck.vptpLkaailktLsaLvkkseee.aakiWrsLDrwifk..gsqllptvp.ttsakkqsgsleekeafesrle 704 
                  +r a+l+n +w++l +l++++ ++ +   L+++++ tLs+++k s+ e ++     +   +    ++ + ++ + + s+k   g+ ++++  e    
  EFC38927.1  613 SRVAILDNTNWRVLGLLFEMMYAPkITPCLMGQVFSTLSSFLKPSQGEpSNIAFAIIS-QMGRilHYEIRDQ-KyEVSSK--GGIKYQLNFREAQEG 705 
                  *******************9976449*****************555553555555555.3322112233333.2233333..788889999999999 PP

                  SHHHHHHHHHHHHHHTSXTTXSSSXXSSXSSXTTTTTTTSSSSSHHHHHHHHH.HHHT.GGGGXXXHHHHHHHHHHHHHHHHHHHHTSXHHHHHHHC CS
      Nup192  705 tysevraflqLlkaLlqpleseseakgklpfPedLGagyRkpGiepYldfvldevflk.strdlkdpaekwelqlsclelletsLasfdpslllfse 800 
                  +y e+ +fl+L++aL++                + G      G+ p+l+f+ ++vf + s+r +kd+++kw +++scl+++ ++L+ + ps ++f e
  EFC38927.1  706 EYYETLGFLELIDALIS----------------STGMA--IVGFTPFLKFIQEDVFNNfSKRYYKDQSDKWLIAKSCLQIFTKLLSRYTPSTSDFEE 784 
                  ****************4................55655..58*****************************************************88 PP

                  CTTTTSSSSTTCHHHHHHHHHSTHHHHHHHHTSHHHHHHHHHHH.XXXHHHHHH...SXTTSHHHHHHHHHHHHHHHHHHHHHHHHTCCHHHHHHHH CS
      Nup192  801 qaginldslvstsdlatyvklhgfaavlnllfkekvlklllkii.eegvdelds.y.asgkseleelvllaLeilekvLelQetfleellpilkkke 894 
                   ++ +       ++ +   ++ gf ++  +l +  + k l+ki+  e+ +  ++ y +++ + le +v +aLei+e +L +++ f++  +  l    
  EFC38927.1  785 VKSSED------ETPKVNDPPAGFQLMRDMLSDTIFRKELFKIViGEDFNLEEErYnNREGEALERSVIYALEIIETTLLKEDDFIKCSTSKL---- 871 
                  888843......67777778889********************86666666666778788***************************995555.... PP

                  CXXXXXXXSXTTXSSHHHHHCCXTHHHHHHHHHGGGTX.HHHHHHHHHHHHHHTTXTTGGTSSXXXXXXSXHHHHHHHHSSXHHHHHHHHHHHHHSX CS
      Nup192  895 niyrpknvgsaglssfedillfnLslvlnialYvgldn.peialaslkiLekissspkvsassasrllkknklltvfesvdeserIkqgfveqLeae 990 
                         +    ++ +e +l +  sl++ ++ ++ +++ +ei +  ++iL+ is++              +kl+++f+ + + + + + fv+ L a 
  EFC38927.1  872 ------HLVPLVIKRLEYQLPN--SLIIRLIDLIDYSHnNEIRYRVVNILCLISKN-------------ATKLVSLFKDKRKEKTVVKLFVKYLHAV 947 
                  ......2333335556444433..66889999***9999****************8.............78************************** PP

                  X.XTTTTTSXHH..........HHHHHHHHHHHHHHHHSSTTSXXHHHHHTTXXXBTBXXXX...TTSTTTTTXSHHHHHHHHHTTXXXXXTTSX.. CS
      Nup192  991 iedeeqeeeeea..........lqiKlaILdlLnsnLsasskeptvahfLLGfdvrndlslgneqqsgviasqssllhsllsllesslelisegdks 1077
                  +++ ++e ++ +           +++l+ LdlL++nL+a+    +++h+L Gfdv+nd   + ++    i +++++l ++l+ll       ++ ++ 
  EFC38927.1  948 TTETNRECSDVEeipvteeqrdNETRLRMLDLLKANLDAP--GENLSHLLCGFDVSNDEPRE-ID----IFNEKTCLTVILNLL-------KS-KQ- 1028
                  9888753333336777777777***************996..88************765555.44....7799***********.......55.44. PP

                  ....BXHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHT.THHHHHHHHXXXXXTTXXBTTBXTTS.....TTSTTSTTHHHHHHHHHHHHHHHHH CS
      Nup192 1078 rgskideaparLaekileillkLcrnpltseltLryLretefllrhllslppkidentlWngqefdgslssnkeflssesigallsFlnqrslllqy 1174
                      +   ++r+ e+++e+++kLc++++ s+ t   L + +fl+ +l +  ++++ + +     ++                     lnqr +++ +
  EFC38927.1 1029 ----LPITHPRFIESCYELIYKLCADRRVSQQTFACLEKANFLIDKLKNANFSTKIEPS----PLA------------------HHILNQRGFVIRI 1099
                  ....99********************************998******998887666666....222..................2469********* PP

                  HHHHTTTTTSS.....SXHHHHHHHHHHHHTEE.XSS.SS.....E..XXXTTTSXXSXXTTSXGGSXXXX CS
      Nup192 1175 lslelhslsqs.....gstskkkrlvdlLlgsn.tae.ee.....engspkildlLdvlnfefkekeeqpq 1233
                  ++l+l s +++     + +  +++lv++L+g+    + +      e++++ +l++Ld++++++ ++ + ++
  EFC38927.1 1100 VALKLYSNTKAfkkgdSNRGGVQELVHILFGGDsLSDfSRsydllEQRRALMLEILDTIDLNLAQNAPAQD 1170
                  *****9876541111144556899*******99655443367888779**************888665544 PP

  == domain 2  score: 114.1 bits;  conditional E-value: 1.5e-36
                  HHHHHHHHHHHHHHHHH...HSXXXSHHHHHHHHHHHHHHHHHHHHHTTTXHH.HHHHHHHHHHHHHTTXXXXXXXX...XXXXHHHHHHHCCTTHH CS
      Nup192 1317 qlkvLhsWvqLvqvlvs...dgelsseersnfilevlqkilpkindyveediq.faeelaslvsvllfdlyeklrqsikkseeqketgnlsserLlq 1409
                  + + ++ W q+v++ +s    +  +   r  ++ ++++++l k+ ++  ++     ++l  lvs ++++++ klr+++ +s+e      l++++ l+
  EFC38927.1 1184 TSNSFDGWKQVVEITLSqcfGMIPDDGMRLRILHDIISSLLFKLFQMKRINKGkQQQKLELLVSQVILRVMSKLREEFITSGEVI---MLPVDQCLT 1277
                  5677899**********97533334556888999**********7777766666888899999999************7775555...9******** PP

                  HHHHHHHHHHHT-.S-HHHHHHHHHHHHHHHHTTT---HHHHH........HHHHHHHHHHHTHHHHHHHHHHHTSS-HHHHHHHHHHHHHHHHH.T CS
      Nup192 1410 lfktciegIlsse.stqkLRsdlYvlllnyLqieasetskanlslke.eslkkeilqiiksygekLieviCnDaitgegvcritalllLdsLvelss 1504
                  +f++++e+Il se s q++R +lY+ l+nyLq ++ ++   n+  ++  +l+k++ +ii  y+ + +  + +Da++++ +++  + +lL++++   +
  EFC38927.1 1278 IFRNLLECILLSEqSEQSIRGNLYSTLINYLQYTKRNE--LNYGSDQiMNLQKNTEHIIDKYDLRVFALVAKDALDAKNIWKAVSYSLLETFFTYTT 1372
                  *********************************44333..3332244469*********************************************76 PP

                  T-.--H.HHHHHHHTTHHHHHHHGGGGH.HHHHH---------.....------HHHHHHHHHHHHHHTSHHHHHHHHH.TTHH.HHHHHHTSSSS- CS
      Nup192 1505 sn.ksnfilellvknnyLkllvrslkrt.dealqeilkpdpes.....ldalyetvfesklalLirlAqtrkGAeqLLq.nklf.svlkeckflaid 1592
                  +  +   +++++ +++ Lk++++s+ +  ++ l ++l+p+ +      l+ l   ++e  +++L++       + +++   +++ ++ ++  f++++
  EFC38927.1 1373 NIaQRGKWITYFESSGCLKQILDSVMTEaKHSLPKVLQPTLHDtdassLNRL--FIYENAMSFLLKFTDVDVKSAEIMMsFEVItKICSHFTFIDLR 1467
                  667999******************9765155677777777666443366667..***************9876666655145551667899****** PP

                  SS---....--S-SS.HHHHH.........HHHHHHHHHHHHHHHHHHHTT-STT...HHHHHHHHHHTTTHHHHHHHHTT....---HHHHHHHHH CS
      Nup192 1593 PDlglkin.sldnpl.lskaln......nteryfellvpvlqLitaillSlGssnksaieqvrklLkahrdlvvgvLKrdalpesklgkeeeeegLk 1681
                  P + +  + +  +++ ++++++      +te+y++l++p+++Li ai  S  + nk+++eqv+++ + hr+ + ++LK +  ++++l  + ++ +L+
  EFC38927.1 1468 PSI-V--ShQYGRKMdMEDDMEadwepsITEKYNQLVIPAIKLIVAI-QSHMRINKKVAEQVLSFVELHRKSISAILKMEN-IQKNLI-NIDSGSLE 1558
                  ***.3..336666666666666788888****************987.66668899*********************9988.666666.34444333 PP

                  H CS
      Nup192 1682 e 1682
                   
  EFC38927.1 1559 L 1559
                  3 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  160.0   0.4   3.2e-50   7.1e-47       4     260 ..    3020    3316 ..    3018    3319 .. 0.83

  Alignments for each domain:
  == domain 1  score: 160.0 bits;  conditional E-value: 3.2e-50
                  EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH..HHSS--HH CS
     Pkinase    4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle..rkgslsee 98  
                  ++++GeGsfG+V++ +  + ++ vAvK+++ ++ + ++ +++ +E +il +l+hp+iv +y++  +++++y+v+e++e+ +l+++++  ++++++++
  EFC38927.1 3020 IKRIGEGSFGRVFSTK--WGNQLVAVKVVDMNDFDMSE-ETFKQEFQILSRLRHPKIVSFYGISFSPTKRYIVMELCEH-SLEHVISqlQNQVIQMD 3112
                  689***********99..9************9998877.59*************************************5.59999998966665555 PP

                  ..HHHHHHHHHHHHHHHHH..HTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH.......TTSCBSHHHHHHH CS
     Pkinase   99 ..eakkiakqilegleylH..skgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl.......keneyskkvDvWs 182 
                    e  +i+  i+eg++ylH    +++HrDlKp NiL++ ++e K++DFG+ k l+s++   lt+ vgt +Y+APE         +e+   +++D++s
  EFC38927.1 3113 lqEKIDILIDIIEGVNYLHtlTPKCLHRDLKPLNILVSFQKEYKLCDFGVGKILNSKTVnsLTNNVGTCYYMAPETTgceslqeSESVCATSIDIYS 3209
                  327779*************54456********************************98788****************9998874445559******* PP

                  HHHHHHHHHHS.S-STTTSSHHHHHHHHHHTHHHHHHHCT........SHH...HHHTTS..............................-HHHHHH CS
     Pkinase  183 lGvilyelltg.kppfsgekgkekvekeldqlekilkilg........etkeklpeasei..............................seeakdl 240 
                  l++i+y+ll++ k+p+ + +++  ++ ++++  +++++ +        +          +                                e+ +l
  EFC38927.1 3210 LAIIFYQLLFEvKEPYISCHDRVLKKLKMNEPLQLTNMYHlhrlviekN----------LrpiipfssakecqqwcqeylsptdakyhsiFYEICQL 3296
                  *******998647788866666666666666333333333222433221..........13345666777889999999********999999**** PP

                  HHHHT-SSGCCSTTHHHHHT CS
     Pkinase  241 lkkllkkdpkkRltaeellq 260 
                   k +++k+pk+R++a+ +l+
  EFC38927.1 3297 TKLCWDKQPKTRPSAKTILE 3316
                  ****************9987 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.7   1.7   1.1e-37   2.5e-34       5     259 .]    3021    3318 ..    3018    3318 .. 0.86

  Alignments for each domain:
  == domain 1  score: 118.7 bits;  conditional E-value: 1.1e-37
                   EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTE..BHHHHHHHTCTT CS
  Pkinase_Tyr    5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgG..dLlkfLrkkeke 98  
                   k++GeG+fG+V++ ++       ++ VavK+++ +  + ++e + +e +i+++l+hp+iv+++g+  +  + +iv+e++++   ++ + L+++   
   EFC38927.1 3021 KRIGEGSFGRVFSTKWG------NQLVAVKVVDMNDFDMSEETFKQEFQILSRLRHPKIVSFYGISFSPTKRYIVMELCEHSleHVISQLQNQ-VI 3109
                   79***************......899******99999999****************************************9533444455554.66 PP

                   TSBHHHHHHHHHHHHHHHHHHHHT..TEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.......EEHH CS
  Pkinase_Tyr   99 kltlkdllsfalqvAkGmeyLesk..klvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.......ftsk 185 
                   +++l++++++ +++ +G++yL++   k++Hrdl   N+L+s +k  k++DfG+ + + ++++ ++ +++   + +mapE+   ++       + ++
   EFC38927.1 3110 QMDLQEKIDILIDIIEGVNYLHTLtpKCLHRDLKPLNILVSFQKEYKLCDFGVGKIL-NSKTVNSLTNNVGTCYYMAPETTGCESlqesesvCATS 3204
                   788899****************86226***************************988.7778888899999999****876444434444779999 PP

                   HHHHHHHHHHHHHHTTSSGT.....................................TTTSHHHHHHHHHHTTEES-BBTTSBH...HHHHHHHHH CS
  Pkinase_Tyr  186 sDvWsfGvllwEiftlgesp.....................................ypglkneevleklkegkrlekpekcpe...elyelmkkc 241 
                    D++s +++ + ++   ++p                                     +  +++++ +++  +++  ++ +k ++   e+ +l k c
   EFC38927.1 3205 IDIYSLAIIFYQLLFEVKEPyischdrvlkklkmneplqltnmyhlhrlvieknlrpIIPFSSAKECQQWCQEYLSPTDAKYHSifyEICQLTKLC 3300
                   9*********************************************9999999998855556666677777888777777666611155666889* PP

                   T-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  242 weedpeeRptfselvekl 259 
                   w+++p+ Rp+ ++++e+l
   EFC38927.1 3301 WDKQPKTRPSAKTILERL 3318
                   ***********9999876 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   1.3e-06    0.0029       1      26 [.    2058    2082 ..    2058    2084 .. 0.87
   2 !   17.0   0.0     2e-06    0.0045       1      27 [.    2326    2351 ..    2326    2352 .. 0.94
   3 !   16.0   0.0     4e-06    0.0089       1      26 [.    2382    2407 ..    2382    2409 .. 0.95
   4 !    6.1   0.0    0.0054        12      12      26 ..    2449    2463 ..    2438    2463 .. 0.83
   5 ?   -2.3   0.0       2.5   5.6e+03      14      26 ..    2504    2516 ..    2504    2516 .. 0.89
   6 ?    2.2   0.0     0.095   2.1e+02      12      25 ..    2558    2571 ..    2547    2572 .. 0.81
   7 ?   -3.0   0.1       4.2   9.4e+03       7      28 .]    2641    2662 ..    2641    2662 .. 0.85
   8 !    8.2   0.0    0.0012       2.6       1      26 [.    2693    2721 ..    2693    2722 .. 0.86
   9 ?   -1.1   0.0       1.1   2.4e+03       3      19 ..    2755    2771 ..    2754    2773 .. 0.82
  10 ?    2.1   0.1       0.1   2.3e+02       9      23 ..    2816    2830 ..    2814    2835 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 1.3e-06
                  BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenhrvq 26  
                  +++P++v v ++G++y++D++nh ++
  EFC38927.1 2058 LSQPQSVFV-KDGEVYICDTNNHLIR 2082
                  567888888.*************997 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 2e-06
                  BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenhrvqv 27  
                  +n+P+G+ + +n  +y++Ds+nhr++v
  EFC38927.1 2326 LNNPRGIFL-KNQKLYISDSNNHRIRV 2351
                  789999999.***************98 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 4e-06
                  BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL    1 fnyPhGvavdsnGdiyVaDsenhrvq 26  
                  +n+P+Gv v+  G iy++Ds+nhr++
  EFC38927.1 2382 LNSPSGVFVSEFGKIYISDSGNHRIR 2407
                  799*********************97 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0054
                  TTEEEEEECCCTEEE CS
         NHL   12 nGdiyVaDsenhrvq 26  
                  +Gd++++Ds n+r++
  EFC38927.1 2449 SGDLIISDSDNNRIR 2463
                  7************96 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 2.5
                  EEEEEECCCTEEE CS
         NHL   14 diyVaDsenhrvq 26  
                  ++y++D++ +r++
  EFC38927.1 2504 RLYISDTYGQRIR 2516
                  58*******9995 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.095
                  TTEEEEEECCCTEE CS
         NHL   12 nGdiyVaDsenhrv 25  
                  n+ iy+aD+ n  +
  EFC38927.1 2558 NNIIYIADTDNKKI 2571
                  799********877 PP

  == domain 7  score: -3.0 bits;  conditional E-value: 4.2
                  EEEETTTEEEEEECCCTEEEEE CS
         NHL    7 vavdsnGdiyVaDsenhrvqvF 28  
                  +a d+  ++y +Ds ++ v++F
  EFC38927.1 2641 LAFDDEKNVYFTDSSHNVVRKF 2662
                  57889999999**999988887 PP

  == domain 8  score: 8.2 bits;  conditional E-value: 0.0012
                  BSSEEEEEEE.TTTE..EEEEECCCTEEE CS
         NHL    1 fnyPhGvavd.snGd..iyVaDsenhrvq 26  
                  +n+P G+av+ s+    +y++D+en+r++
  EFC38927.1 2693 LNFPKGIAVSkSSLGffLYICDFENQRIR 2721
                  79999****9999973469********97 PP

  == domain 9  score: -1.1 bits;  conditional E-value: 1.1
                  SEEEEEEETTTEEEEEE CS
         NHL    3 yPhGvavdsnGdiyVaD 19  
                  +P+ +av++ G+++ +D
  EFC38927.1 2755 NPTHIAVNKEGEVFFSD 2771
                  6899********98666 PP

  == domain 10  score: 2.1 bits;  conditional E-value: 0.1
                  EETTTEEEEEECCCT CS
         NHL    9 vdsnGdiyVaDsenh 23  
                  vd++G i+V D++n+
  EFC38927.1 2816 VDNTGSIVVFDYNNQ 2830
                  899***********7 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.013        29     193     237 ..    2067    2112 ..    2006    2117 .. 0.82
   2 !    7.9   0.0   0.00088         2     143     215 ..    2334    2414 ..    2284    2419 .. 0.84
   3 !    7.8   0.1     0.001       2.3      12     214 ..    2503    2728 ..    2498    2739 .. 0.64
   4 ?    3.8   0.0     0.016        36     144     215 ..    2645    2729 ..    2642    2825 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.013
         SGL  193 aeGnvwvAvwgggkvvrfdpdGklieeiklp.akrvtscaFgGpdl 237 
                  ++G+v+++  +++ ++r+d +G l +  +   ++ +  ++F+G+d+
  EFC38927.1 2067 KDGEVYICDTNNHLIRRIDRNGILWNVFQKGfVREPQQLIFAGNDM 2112
                  58****************************9888********9995 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00088
         SGL  143 pdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge........gepDGlavDaeGnvwvAvwgggkvvrfdpdGk 215 
                    +++lY+ Ds +++i ++d+++      +   +a+++ ++        + p G++v + G++++   g+++++ + p+G 
  EFC38927.1 2334 LKNQKLYISDSNNHRIRVIDIQTGLISTLAGNGIANFSGDGlaateaslNSPSGVFVSEFGKIYISDSGNHRIRAILPNGI 2414
                  46789****************866666667778899999999999999877*************************99994 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.001
         SGL   12 gaLlwvDilgqrihrldpatgketv........ldtpesvGaiap.rkd.....grlvvasksglalldlasgeletlade.eedekpllrfNDgvv 93  
                   +L+ +D +gqri + ++++++ ++        +     +G  +p +         + ++ ++ +++ d+++++++ l +  ++       +  g  
  EFC38927.1 2503 SRLYISDTYGQRIREANLESKTVKTiigtgekgY-----NGDNFPtT-TqlnnpLSMFITYNNIIYIADTDNKKIRMLNTGiVSTLELTFESPKGIT 2593
                  6899999999999999999999998544333331.....44444421.2233345556666666666666666666666653222223444445666 PP

         SGL   94 dpdGrlwfGtmgdeeakgeevgalyrldpdgklervlddltipNGlaws.pdgktlYlaDsltrkiwaydvdaeg.gklsnrrvfadlkkge..... 183 
                   +d  l++++ +  ++ +  +g  + + ++g    +  + +i N+ ++   d+k +Y++Ds ++ + +++      +++  r+  +  + ++     
  EFC38927.1 2594 GDDKFLYITDGNLVKKIDIANGYRVEIIGGGIGDGWYLKYAILNAENLAfDDEKNVYFTDSSHNVVRKFNTMNGIvSTVAGRTSTLGYEGDGglavg 2690
                  6777799999998888888556666666668889999999999998887367899**************9865431334444444333333356777 PP

         SGL  184 ...gepDGlavDaeG...nvwvAvwgggkvvrfdpd.G 214 
                     + p G+av ++     ++++ +++++++r++ + G
  EFC38927.1 2691 allNFPKGIAVSKSSlgfFLYICDFENQRIRRVNLEtG 2728
                  77655888888774322347788888888888877744 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.016
         SGL  144 dgktlYlaDsltrkiwaydvdaeg.gklsnrrvfadlkkge........gepDGlavDaeG...nvwvAvwgggkvvrfdpd.Gk 215 
                  d+k +Y++Ds ++ + +++      +++  r+  +  + ++        + p G+av ++     ++++ +++++++r++ + G 
  EFC38927.1 2645 DEKNVYFTDSSHNVVRKFNTMNGIvSTVAGRTSTLGYEGDGglavgallNFPKGIAVSKSSlgfFLYICDFENQRIRRVNLEtGI 2729
                  8888999999999999888754331233333333333333355776665557777777633122467777777777777766443 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6  11.2   7.1e-06     0.016       6      32 .]    2866    2891 ..    2857    2891 .. 0.92
   2 !   14.3  10.6   1.7e-05     0.039       5      32 .]    2902    2928 ..    2896    2928 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 7.1e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++C+ hG C ++  qC+C sgy+G +C
  EFC38927.1 2866 NACSSHGFCKSLD-QCECYSGYSGSNC 2891
                  78********999.************* PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1.7e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +C+g G+Cv+++ +C+C + y+G +C
  EFC38927.1 2902 SGACNGKGICVSPN-VCQCLDDYSGIDC 2928
                  678********999.************* PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.6   3.7e+03      29      48 ..     665     684 ..     660     689 .. 0.78
   2 ?   -2.8   0.0       3.2   7.3e+03       3      79 ..    2237    2254 ..    2230    2262 .. 0.60
   3 ?   10.8   0.0   0.00018       0.4       5      83 ..    2643    2722 ..    2639    2727 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.6
   Str_synth  29 allegdktGrllkydkstkv 48 
                 a+    + Gr+l+y++  ++
  EFC38927.1 665 AFAIISQMGRILHYEIRDQK 684
                 66666789******998776 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.2
   Str_synth    3 ldvdeetgvlyftdsSskydrrqvllallegdktGrllkydkstkvvkvlldkLyfanGialsedgsfvlvcetamk 79  
                  +++ ee++ ++ft+ Ss                                                           +
  EFC38927.1 2237 MTLCEEDNSIIFTQHSS-----------------------------------------------------------S 2254
                  55555656666666554...........................................................3 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 0.00018
   Str_synth    5 vdeetgvlyftdsSskydrrqvllallegdktGrllkydkstkvvkvlldkLyfanGialsed..gsfvlvcetamkrisr 83  
                   d+e   +yftdsS++  r+   ++ +     Gr   +  +      +   L f+ Gia+s+   g f+ +c++  +ri r
  EFC38927.1 2643 FDDE-KNVYFTDSSHNVVRKFNTMNGIVSTVAGRTSTLGYEGDGGLAVGALLNFPKGIAVSKSslGFFLYICDFENQRIRR 2722
                  5666.89*******9998865555666677889*99988888888889999*********99744678899*******988 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   3.2   8.7e-06      0.02       4      32 .]    2866    2890 ..    2863    2890 .. 0.90
   2 ?   -2.9   6.4       3.9   8.8e+03       6      31 ..    2905    2926 ..    2896    2927 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 8.7e-06
                  TTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    4 npCsngGtCvdtgrggytCiCpeGytGkr 32  
                  n Cs +G+C ++     +C+C +Gy+G++
  EFC38927.1 2866 NACSSHGFCKSLD----QCECYSGYSGSN 2890
                  66*******9999....**********86 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.9
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  C++ G+Cv++      C+C   y+G+
  EFC38927.1 2905 CNGKGICVSPN----VCQCLDDYSGI 2926
                  *******9999....9****999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (3330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1136  (0.063361); expected 358.6 (0.02)
Passed bias filter:                      586  (0.0326845); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.53u 0.37s 00:00:01.90 Elapsed: 00:00:00.58
# Mc/sec: 17262.88
//
Query:       EFC38928.1  [L=567]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.3   11.6   7.5        6.5    7.3   3.9    2.6  2  FtsX      FtsX-like permease family
          3    7.7   5.0          6    6.8   0.5    2.4  2  DUF3487   Protein of unknown function (DUF3487)


Domain annotation for each model (and alignments):
>> FtsX  FtsX-like permease family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   3.9   0.00072       6.5      61      92 ..      29      60 ..      11      63 .. 0.80
   2 ?    5.0   0.1    0.0038        34      25      54 ..     371     400 ..     343     421 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00072
        FtsX 61 kisidlitvliiivlllllallagllsiskil 92
                + +++ i +l+ii+++ll+++ ++lls++ i+
  EFC38928.1 29 TTFFSSIKFLLIILISLLILISVVLLSVIWIS 60
                56789999***************999998876 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0038
        FtsX  25 illitlvalviGlglgllaaqllsdvllss 54 
                 +++i+++++++G +l + +a+ +   ++++
  EFC38928.1 371 SMVIAIICAILGSILIVSIAKTSCGQIGKF 400
                 567888888888777777777766666665 PP

>> DUF3487  Protein of unknown function (DUF3487)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.4     0.016   1.4e+02      23      62 ..      25      63 ..      23     102 .. 0.66
   2 ?    6.8   0.5   0.00067         6      32      71 ..     354     393 ..     347     399 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.016
     DUF3487 23 dEllvlaglglvvglvlglllallvgslaliptialllvl 62
                dEl +++ +++ + l++ + l++l++ ++l+  i + +  
  EFC38928.1 25 DELKTTFFSSIKFLLIILISLLILIS-VVLLSVIWISSFS 63
                78888888888888888777777777.4443333333333 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.00067
     DUF3487  32 glvvglvlglllallvgslaliptialllvllvvlvggkl 71 
                 gl   lv +++ +  +gs+++ + +a+l+ +l+v ++++ 
  EFC38928.1 354 GLEWVLVFSVPHWNYIGSMVIAIICAILGSILIVSIAKTS 393
                 6777899***************************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (567 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       985  (0.0549389); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 3567.07
//
Query:       EFC38929.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.18   11.7   0.0       0.39   10.6   0.0    1.5  1  LpxI_N    LpxI N-terminal domain


Domain annotation for each model (and alignments):
>> LpxI_N  LpxI N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   2.2e-05      0.39      45     114 ..     237     310 ..     221     317 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 2.2e-05
      LpxI_N  45 evaevsvgqlgklikaLkregvtevvmaGkvekpklldlrp.Dlralkllak...lkdrgddalLravveelek 114
                 e a++++++++++ + Lk +++t  + aGkv   + ++++  Dlral++l +   + ++  + l+ ++ + le+
  EFC38929.1 237 EAAQFHLEACKQIERGLKPRKATVFTSAGKVITFDYFSILEkDLRALHVLGQryrRVSASHSDLMLEISQILER 310
                 568999*************************99999977777********997643367777888888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       580  (0.0323498); expected 358.6 (0.02)
Passed bias filter:                      350  (0.0195214); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 2118.75
//
Query:       EFC38930.1  [L=651]
Description: hypothetical protein NAEGRDRAFT_73200 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.1e-15   55.3  42.9    1.8e-05   25.0   0.6    9.9 11  LRR_4       Leucine Rich repeats (2 copies)
    7.9e-12   44.2  29.4      0.002   18.0   0.0   11.0 12  LRR_6       Leucine Rich repeat
    0.00043   20.1   0.0     0.0014   18.5   0.0    1.8  1  F-box-like  F-box-like
     0.0014   18.4  27.7      0.063   13.0   1.4    7.7  8  LRR_8       Leucine rich repeat
     0.0018   18.5  18.5        6.4    7.7   0.1    8.9  7  LRR_1       Leucine Rich Repeat
  ------ inclusion threshold ------
       0.09   12.3  10.8        5.7    6.4   0.1    4.2  4  LRR_9       Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0         3     9e+03      12      30 ..      36      53 ..      34      56 .. 0.76
   2 ?   -3.5   0.0       5.4   1.6e+04      22      33 ..     109     119 ..     102     124 .. 0.59
   3 !   17.3   2.1   1.6e-06    0.0048       3      36 ..     143     178 ..     141     185 .. 0.83
   4 !    5.8   0.0    0.0066        20       1      38 [.     190     225 ..     190     231 .. 0.84
   5 ?    1.9   0.1      0.11   3.2e+02      22      39 ..     244     260 ..     238     264 .. 0.77
   6 ?    1.0   1.6      0.21   6.2e+02       1      30 [.     272     305 ..     272     317 .. 0.69
   7 !   13.7   0.2   2.2e-05     0.064       1      33 [.     326     364 ..     326     368 .. 0.85
   8 !    7.2   0.1    0.0024       7.3       3      38 ..     383     421 ..     380     431 .. 0.72
   9 !    6.7   0.0    0.0034        10      15      30 ..     454     468 ..     433     473 .. 0.64
  10 ?   -3.0   0.0       3.9   1.2e+04      21      37 ..     529     544 ..     523     545 .. 0.58
  11 !   25.0   0.6   5.9e-09   1.8e-05       2      37 ..     559     598 ..     558     626 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 3
                ---E-S-HHH-TT--EEE- CS
       LRR_4 12 qltdiplleklpnLkeLdL 30
                 +td ++++ + +Lk ++L
  EFC38930.1 36 LITDGSSIR-NSSLKIVSL 53
                578878888.899999988 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 5.4
                 -TT--EEE-.-S CS
       LRR_4  22 lpnLkeLdLsgN 33 
                 + + k+L+L + 
  EFC38930.1 109 FQSVKSLSL-RD 119
                 666677777.33 PP

  == domain 3  score: 17.3 bits;  conditional E-value: 1.6e-06
                 --EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                  ++L+  nN l  ++     eklpnL+++d+s+N +i
  EFC38930.1 143 ITELSVENNGLNNLDInliAEKLPNLTHIDISSN-PI 178
                 5889999*99999999964448*********999.54 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0066
                 SS--EEE--SS---E-S-HH..H-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitd 38 
                 ++L+++  + N + d   l   k+++ +eL++s+     d
  EFC38930.1 190 QKLKTIFAGVNEIEDETDLDkmKCTQIEELTISNT----D 225
                 68999999989***988888777999******664....5 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.11
                 -TT--EEE-.-S-----G CS
       LRR_4  22 lpnLkeLdLsgNnlitdl 39 
                 l+n+keLdL   +l++d+
  EFC38930.1 244 LKNMKELDL-MDTLPSDV 260
                 99******9.55577776 PP

  == domain 6  score: 1.0 bits;  conditional E-value: 0.21
                 SS--EEE--SS-.....--E-S-HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNq.....ltdiplleklpnLkeLdL 30 
                 +n ++L+L  N      l  i   + l nLk+L L
  EFC38930.1 272 TNITFLNLEYNEllpetLAIITQSQALSNLKTL-L 305
                 688888888887566664444444459999998.5 PP

  == domain 7  score: 13.7 bits;  conditional E-value: 2.2e-05
                 SS--EEE--SS---E-S-..HH....H-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..le....klpnLkeLdLsgN 33 
                 +n ++Ld snN + d ++  ++     l+nL ++ ++ N
  EFC38930.1 326 KNVTKLDVSNNTIGDEGFihFGtenfTLKNLIHFKCNTN 364
                 699************999773366666*********777 PP

  == domain 8  score: 7.2 bits;  conditional E-value: 0.0024
                 --EEE--SS---E-S-..HH..H-TT--EEE-.-S----- CS
       LRR_4   3 LevLdLsnNqltdipl..le..klpnLkeLdLsgNnlitd 38 
                 L++L +++++  d +   l+  +l +Lk+Ld  gN  itd
  EFC38930.1 383 LQKLKIADTNFDDDSVseLAsaNLASLKVLDFVGN-IITD 421
                 88888888886643333433546********9999.5554 PP

  == domain 9  score: 6.7 bits;  conditional E-value: 0.0034
                 E-S-HHH-TT--EEE- CS
       LRR_4  15 diplleklpnLkeLdL 30 
                  +++++ lpnLk+Ld+
  EFC38930.1 454 FLENCS-LPNLKYLDI 468
                 455555.********9 PP

  == domain 10  score: -3.0 bits;  conditional E-value: 3.9
                 H-TT--EEE-.-S---- CS
       LRR_4  21 klpnLkeLdLsgNnlit 37 
                 +l  L +L + + n+i+
  EFC38930.1 529 GLSELISLCI-QVNFID 544
                 5666666655.555664 PP

  == domain 11  score: 25.0 bits;  conditional E-value: 5.9e-09
                 S--EEE--SS---E-S-..HH...H-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLsgNnlit 37 
                 +Le+L+Ls+N++td++   ++   +++nL eL++ +N l t
  EFC38930.1 559 KLEKLYLSDNKITDVGAklISecaQFKNLLELSCEDN-LFT 598
                 7*****************7225659*********777.665 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       1.3   3.8e+03       4      15 ..     111     122 ..     110     122 .. 0.83
   2 ?   -2.3   0.4       2.2   6.7e+03       6      17 ..     144     155 ..     143     158 .. 0.80
   3 !    9.0   0.2   0.00054       1.6       3      21 ..     166     184 ..     164     187 .. 0.85
   4 ?    0.4   0.0       0.3   9.1e+02       2      17 ..     213     228 ..     212     229 .. 0.90
   5 ?   -0.4   0.0      0.55   1.6e+03       4      13 ..     246     255 ..     244     264 .. 0.77
   6 ?    0.7   0.1      0.25   7.3e+02       2      15 ..     271     284 ..     270     285 .. 0.86
   7 !   15.3   0.1   5.1e-06     0.015       4      19 ..     327     342 ..     326     347 .. 0.89
   8 ?    4.2   0.1     0.019        56       4      24 .]     382     402 ..     379     402 .. 0.91
   9 !    6.5   0.1    0.0032       9.7       4      23 ..     408     427 ..     405     428 .. 0.86
  10 ?   -0.5   0.0      0.57   1.7e+03       3      10 ..     461     468 ..     459     470 .. 0.82
  11 !   18.0   0.0   6.7e-07     0.002       4      24 .]     559     579 ..     556     579 .. 0.92
  12 ?    0.1   0.0      0.37   1.1e+03       5      20 ..     587     602 ..     585     606 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.3
       LRR_6   4 hLteLdLsgNdI 15 
                 ++++L+L++ +I
  EFC38930.1 111 SVKSLSLRDSKI 122
                 789****99776 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2.2
       LRR_6   6 teLdLsgNdIgD 17 
                 teL++  N++++
  EFC38930.1 144 TELSVENNGLNN 155
                 899999998865 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00054
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 ++Lt+ d+s+N I+  G+ 
  EFC38930.1 166 PNLTHIDISSNPINEGGLD 184
                 89***********988875 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.3
       LRR_6   2 nthLteLdLsgNdIgD 17 
                 +t ++eL +s  d+gD
  EFC38930.1 213 CTQIEELTISNTDFGD 228
                 8899***********9 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.55
       LRR_6   4 hLteLdLsgN 13 
                 +++eLdL++ 
  EFC38930.1 246 NMKELDLMDT 255
                 799****875 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.25
       LRR_6   2 nthLteLdLsgNdI 15 
                  t++t L+L +N++
  EFC38930.1 271 PTNITFLNLEYNEL 284
                 5899********85 PP

  == domain 7  score: 15.3 bits;  conditional E-value: 5.1e-06
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 ++t+Ld+s N IgDeG
  EFC38930.1 327 NVTKLDVSNNTIGDEG 342
                 689************9 PP

  == domain 8  score: 4.2 bits;  conditional E-value: 0.019
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  L++L +++ +++D+ ++ La
  EFC38930.1 382 GLQKLKIADTNFDDDSVSELA 402
                 599***************997 PP

  == domain 9  score: 6.5 bits;  conditional E-value: 0.0032
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +L+ Ld  gN I+D+G e L
  EFC38930.1 408 SLKVLDFVGNIITDKGFETL 427
                 8***************7666 PP

  == domain 10  score: -0.5 bits;  conditional E-value: 0.57
       LRR_6   3 thLteLdL 10 
                 ++L++Ld+
  EFC38930.1 461 PNLKYLDI 468
                 79*****8 PP

  == domain 11  score: 18.0 bits;  conditional E-value: 6.7e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +L++L Ls+N+I+D+Ga+ ++
  EFC38930.1 559 KLEKLYLSDNKITDVGAKLIS 579
                 79***************9985 PP

  == domain 12  score: 0.1 bits;  conditional E-value: 0.37
       LRR_6   5 LteLdLsgNdIgDeGa 20 
                 L eL+  +N ++DeG 
  EFC38930.1 587 LLELSCEDNLFTDEGW 602
                 566666799*****95 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   4.6e-07    0.0014       6      37 ..       7      39 ..       7      43 .. 0.92

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 4.6e-07
  F-box-like  6 dEiLlqIFsyLppsdLlr.lalVCrrWrrvald 37
                +EiL ++F +Lp + L + +++VC+ W+ ++ d
  EFC38930.1  7 PEILGEVFTFLPYRLLFNtIRRVCKEWNHLITD 39
                7*****************88**********976 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.68     2e+03      21      37 ..     106     122 ..      97     126 .. 0.66
   2 !   13.0   1.4   2.1e-05     0.063       3      38 ..     143     179 ..     141     201 .. 0.89
   3 ?   -0.1   0.2      0.26   7.8e+02      50      61 .]     273     284 ..     244     284 .. 0.70
   4 ?    1.5   0.5     0.085   2.5e+02      25      37 ..     326     338 ..     299     340 .. 0.69
   5 ?    0.9   0.1      0.13   3.8e+02       2      13 ..     327     338 ..     326     360 .. 0.74
   6 !    6.6   0.1    0.0021       6.4       2      41 ..     382     423 ..     372     432 .. 0.63
   7 ?    0.2   0.0      0.21   6.4e+02      24      32 ..     460     468 ..     458     470 .. 0.58
   8 !    9.4   0.1    0.0003      0.89       2      22 ..     559     579 ..     556     615 .. 0.65

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.68
                 STT-TT--EEE--SS-- CS
       LRR_8  21 FkglsnLkvLdLsnNll 37 
                  + ++++k+L+L++ ++
  EFC38930.1 106 LHYFQSVKSLSLRDSKI 122
                 55567777777777665 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 2.1e-05
                 -SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS--- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllt 38 
                  t+L++ nN l++ld       l+nL+++d+s+N ++
  EFC38930.1 143 ITELSVENNGLNNLDINLIAEkLPNLTHIDISSNPIN 179
                 689**************99988************887 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.26
                 S-.EEE--SS-- CS
       LRR_8  50 sLrsLdLsgNrL 61 
                 ++++L+L++N L
  EFC38930.1 273 NITFLNLEYNEL 284
                 566666666654 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.085
                 TT--EEE--SS-- CS
       LRR_8  25 snLkvLdLsnNll 37 
                 +n++ Ld snN++
  EFC38930.1 326 KNVTKLDVSNNTI 338
                 5677777777766 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.13
                 T-SEEE-TTS-- CS
       LRR_8   2 nLtsLdLsnNrl 13 
                 n+t+Ld+snN +
  EFC38930.1 327 NVTKLDVSNNTI 338
                 455555555544 PP

  == domain 6  score: 6.6 bits;  conditional E-value: 0.0021
                 T-SEEE-TTS--S..EE-TTSSTT-TT--EEE--SS---GGG CS
       LRR_8   2 nLtsLdLsnNrlt..slddeaFkglsnLkvLdLsnNllttls 41 
                 +L++L + ++++   s++  a  +l +LkvLd   N +t   
  EFC38930.1 382 GLQKLKIADTNFDddSVSELASANLASLKVLDFVGNIITDKG 423
                 566777777665411456666677888888887777666654 PP

  == domain 7  score: 0.2 bits;  conditional E-value: 0.21
                 -TT--EEE- CS
       LRR_8  24 lsnLkvLdL 32 
                 l+nLk+Ld+
  EFC38930.1 460 LPNLKYLDI 468
                 556666654 PP

  == domain 8  score: 9.4 bits;  conditional E-value: 0.0003
                 T-SEEE-TTS--SEE-TTSST CS
       LRR_8   2 nLtsLdLsnNrltslddeaFk 22 
                 +L++L+Ls+N++t+++ +  +
  EFC38930.1 559 KLEKLYLSDNKITDVGAKLIS 579
                 355555555555555554443 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.2       1.2   3.6e+03       3      18 ..     144     159 ..     142     163 .. 0.76
   2 !    7.7   0.1    0.0021       6.4       1      12 [.     167     178 ..     167     196 .. 0.82
   3 ?    1.7   0.6      0.21   6.4e+02       1      13 [.     273     291 ..     273     322 .. 0.75
   4 ?    1.8   0.0       0.2   5.9e+02       1      15 [.     327     341 ..     327     356 .. 0.72
   5 ?    3.4   0.0     0.059   1.8e+02       1      21 [.     408     428 ..     408     430 .. 0.85
   6 ?    0.3   0.0      0.61   1.8e+03       1       8 [.     462     469 ..     462     479 .. 0.89
   7 !    7.0   0.1    0.0036        11       1      21 [.     559     579 ..     559     599 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.2
       LRR_1   3 rhLdLsnnpllglppn 18 
                 ++L ++nn l +l +n
  EFC38930.1 144 TELSVENNGLNNLDIN 159
                 68999***99766655 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0021
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+h+d+s+np+
  EFC38930.1 167 NLTHIDISSNPI 178
                 8**********8 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.21
       LRR_1   1 nLrhLdLsnnpl......l 13 
                 n + L+L++n l      +
  EFC38930.1 273 NITFLNLEYNELlpetlaI 291
                 56789****9985555552 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.2
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 n ++Ld+snn +++ 
  EFC38930.1 327 NVTKLDVSNNTIGDE 341
                 5679******98443 PP

  == domain 5  score: 3.4 bits;  conditional E-value: 0.059
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld  +n++++++ ++++
  EFC38930.1 408 SLKVLDFVGNIITDKGFETLS 428
                 69**********999888776 PP

  == domain 6  score: 0.3 bits;  conditional E-value: 0.61
       LRR_1   1 nLrhLdLs 8  
                 nL++Ld+ 
  EFC38930.1 462 NLKYLDID 469
                 8*****94 PP

  == domain 7  score: 7.0 bits;  conditional E-value: 0.0036
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L+Ls+n +++ ++  ++
  EFC38930.1 559 KLEKLYLSDNKITDVGAKLIS 579
                 7**********9766655544 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   1.0    0.0032       9.6      62     133 ..     139     210 ..     119     247 .. 0.78
   2 ?    4.0   0.4      0.01        30      40     101 ..     249     312 ..     229     341 .. 0.75
   3 ?   -1.7   0.0      0.58   1.7e+03      49      96 ..     393     441 ..     384     468 .. 0.61
   4 ?    6.4   0.1    0.0019       5.7      50      93 ..     544     587 ..     535     615 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0032
       LRR_9  62 llkrlktlllnnnrivriaegl.eevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrl 133
                  l+ +  l+++nn + ++  +l +e lPnl+++ +++n ++e + ld l + +kl+++    n + ++++  +
  EFC38930.1 139 TLEGITELSVENNGLNNLDINLiAEKLPNLTHIDISSNPINE-GGLDVLLTNQKLKTIFAGVNEIEDETDLDK 210
                 57778899999**9999997754899*************998.568999999999988777776666666555 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.01
       LRR_9  40 tldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegl...eevlPnleelvltnnelq 101
                  ld +dt+  sd  +  + ++P+   +  l l+ n ++  +  +   +++l nl++l+l n ++ 
  EFC38930.1 249 ELDLMDTL-PSDVGLSYMKNYPYPTNITFLNLEYNELLPETLAIitqSQALSNLKTLLLPNGSIL 312
                 47888999.79999*******************9998754433222268999****999987753 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.58
       LRR_9  49 lsdndirkldgfPllkrlktlllnnnrivria.egleev.lPnleelvlt 96 
                 ++d+ + +l +   l  lk+l +  n i+  + e l++   P+le+++  
  EFC38930.1 393 FDDDSVSELASA-NLASLKVLDFVGNIITDKGfETLSQLkAPKLEKILCG 441
                 556666666543.4566677766666666444255555325666666655 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.0019
       LRR_9  50 sdndirkldgfPllkrlktlllnnnrivriaegleevlPnleel 93 
                 +d+ i  l + P   +l+ l+l++n+i+ ++ +l     ++++l
  EFC38930.1 544 DDDHIILLTSHPQAAKLEKLYLSDNKITDVGAKLISECAQFKNL 587
                 57889999**********************99987766665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (651 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       591  (0.0329634); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 3826.05
//
Query:       EFC38931.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-30  105.7   0.1    1.3e-28   99.5   0.1    2.3  1  DSPc           Dual specificity phosphatase, catalytic domain
    3.4e-06   26.8   0.1    3.2e-05   23.6   0.0    2.1  2  Y_phosphatase  Protein-tyrosine phosphatase
  ------ inclusion threshold ------
      0.022   15.0   0.0      0.039   14.2   0.0    1.4  1  Init_tRNA_PT   Rit1 DUSP-like domain


Domain annotation for each model (and alignments):
>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.5   0.1   2.1e-32   1.3e-28       1     133 []      42     203 ..      42     203 .. 0.90

  Alignments for each domain:
  == domain 1  score: 99.5 bits;  conditional E-value: 2.1e-32
                 EEEEECCHHC...HHHHHHHTCSEEEEESSSSSEC..........................ECCTTTTSEEEEECCESSTTSCCGGGHHHHHHHHHHHH CS
        DSPc   1 lylgskstas...lallsklgitlvinvtkevpna..........................nalkkseieklripvedehetkiskyleeavefidkak 70 
                 lylg k++a+   +al ++++it+ +nv+++ +n+                           +  +s i+ l++p  d  + k++  l++a efi+k+ 
  EFC38931.1  42 LYLGGKTAAEidhQALYEAFSITHLLNVSETPNNNtccniksnsddenennliiddenennEKETNSPIQSLHLPFLDAPNGKLEHILPQAFEFIEKCF 140
                 79999999988778889999********97777669999888888888888888888777655667788888888888********************* PP

                 HTT-EEEEEESSSSSHHHHHHHHHHHHHHTSCHHHHHHHHHHHSTT-SSTHHHHHHHHHHHHH CS
        DSPc  71 qkgkkvlVHCqaGisRSatliiaYlmktknlslneayeflkerrpaispnagfirqLleyekk 133
                 ++++  lVHC+aG+sRSa++++a++m++++++l+  ++++kerrp++ pn+gfi +L e ek+
  EFC38931.1 141 EQKGCLLVHCRAGVSRSASVVAAFIMYRFGFNLKRVLSLMKERRPSVDPNFGFIYKLKELEKQ 203
                 ***********************************************************9975 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1     0.055   3.3e+02      28      48 ..       2      23 ..       1      30 [. 0.84
   2 !   23.6   0.0   5.3e-09   3.2e-05     108     195 ..      80     168 ..      58     189 .. 0.64

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.055
                   TEEEEEEEEECT.EEEEEEEEE CS
  Y_phosphatase 28 dYInAnyikgyk.kekkyIatQ 48
                   +YI An+i +y+  ek+ I+t 
     EFC38931.1  2 EYIGANLILSYSsAEKNAIITH 23
                   5*******99996699999885 PP

  == domain 2  score: 23.6 bits;  conditional E-value: 5.3e-09
                    EEEEEESSEEEEEEEEEETTTTEEEEEEEEEEESSS-SSSSG.....SCCHHHHHHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHHHHHHH CS
  Y_phosphatase 108 kekedekeyvlrelevkkkkeeseerevkqlqytnWpdhgvp.....esaksllklirkvekskeaksgpvvVhCsaGvgRtgtfvaldillq 195
                    ++k+++++ + ++l +++++e++e+++ + +q  + p  ++p     +   +++++i+k+ ++k    g ++VhC aGv+R++++va+ i+++
     EFC38931.1  80 NIKSNSDDENENNLIIDDENENNEKETNSPIQSLHLPFLDAPngkleHILPQAFEFIEKCFEQK----GCLLVHCRAGVSRSASVVAAFIMYR 168
                    2333333334444444444444433333555555555555552001044455559999999999....******************9998875 PP

>> Init_tRNA_PT  Rit1 DUSP-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   6.6e-06     0.039      16      63 ..     124     169 ..     110     198 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 6.6e-06
  Init_tRNA_PT  16 nLrtalpkivdfvrkrlsedkkkkilvacetGkdlsvgvaLailcklf 63 
                   +L+++lp++ +f++k ++++    +lv+c  G + s++v+ a +++ f
    EFC38931.1 124 KLEHILPQAFEFIEKCFEQKG--CLLVHCRAGVSRSASVVAAFIMYRF 169
                   799*************99876..9**************9999999888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       895  (0.0499191); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.35s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 1461.04
//
Query:       EFC38932.1  [L=295]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.044   13.3   0.3      0.048   13.1   0.3    1.2  1  UCH             Ubiquitin carboxyl-terminal hydrolase
      0.061   13.4   1.0       0.18   11.9   0.6    2.1  2  Staphostatin_B  Staphostatin B
       0.18   10.6   0.2        0.2   10.4   0.2    1.1  1  LptF_LptG       Lipopolysaccharide export system permease Lpt


Domain annotation for each model (and alignments):
>> UCH  Ubiquitin carboxyl-terminal hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.3   8.1e-06     0.048      31     118 ..      77     182 ..       8     261 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 8.1e-06
                 TCHHCCSSTCCCCC-.TT.TTS.TTHHHHHHHHHHHHHH.....SH-CCEE--......HHHHHHHHHHSGGGTSSSTCEHHHHHHHHHHHHHHHHCC. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx. RF
         UCH  31 sleevkkesrnkkelnesnplgkkgelakalkdlfkell.....kskskavsP......kklkktlsklaksfsgykqqDaqEflaflLdqlhedlnr. 117
                 ++ ++  + rn+++++    lg+ ++l +++++lf +l      +++s+ v        +++++t+s + ++ s+ + +D qE+  +l+d++ ++ln+ 
  EFC38932.1  77 QTIHKIVKHRNDQTIS-IRILGQPTHLKEEIQQLFLSLFnvvedGDNSSDVVVyfveniETVYETVSDSPERVSNASDNDPQELSHNLFDRVTNELNSd 174
                 4444444444444442.2334444568888888888887766663333333224555556799**********************************96 PP

                 .......H CS
                 .......x RF
         UCH 118 .......e 118
                        +
  EFC38932.1 175 isitgnyN 182
                 66665442 PP

>> Staphostatin_B  Staphostatin B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.6     3e-05      0.18      18      83 ..       4      73 ..       1      97 [. 0.77
   2 ?   -2.3   0.0      0.77   4.6e+03      46      58 ..     234     246 ..     226     275 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3e-05
                    HHHHHHTT-EEEEETTTTEEEEEEE....--TT-SSEEEEEEEETTTTEEEEEETTEEEEEEEEEEEETT CS
  Staphostatin_B 18 eqtninlfignwsnhqlqksicirh....gddtshnqyhilfidtahqrikfssidneeiiyildyddtq 83
                     qt ++ f g ws   +qk+ c        d   +nq +++f+   ++   fs i ++  +++    d +
      EFC38932.1  4 FQTFLQNFRGLWSRNTIQKTQCKPSleilEDCFKKNQEKVVFVSFGKKEAIFSNIPENYFLFVQKETDFD 73
                    5899999***************6542222566789********************999998886544433 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.77
                     T-SSEEEEEEEET CS
  Staphostatin_B  46 tshnqyhilfidt 58 
                      s+++y +lf+  
      EFC38932.1 234 LSRENYCVLFLPM 246
                     5777777777643 PP

>> LptF_LptG  Lipopolysaccharide export system permease LptF/LptG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.2   3.4e-05       0.2     138     248 ..      48     161 ..      28     275 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 3.4e-05
   LptF_LptG 138 llikpgvfikdgdgyiiyvgsmddeggelqdv.tiydltegkgltsiitAksgvlvksadelqlrLfngeiyevgddek...kysretfer.yridinl 231
                 +  k+ +f++  ++y+++v++  d +   q +  i ++ ++++++ +i+ +  +l+++ ++l l+Lfn+      d+++   +y  e++e+ y++   +
  EFC38932.1  48 FGKKEAIFSNIPENYFLFVQKETDFDLIHQTIhKIVKHRNDQTISIRILGQPTHLKEEIQQLFLSLFNVVEDG--DNSSdvvVYFVENIETvYETVSDS 144
                 47899****************99998844444545555467778889*********9999*********9633..333357955555555414444445 PP

   LptF_LptG 232 dpadlsteeespdelsl 248
                 +  + + ++++p+els 
  EFC38932.1 145 PERVSNASDNDPQELSH 161
                 55555566666644442 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (295 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       797  (0.0444531); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.35s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1658.42
//
Query:       EFC38933.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       513  (0.0286129); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 794.44
//
Query:       EFC38934.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-08   33.5   0.0    1.1e-07   32.1   0.0    1.8  2  OSCP      ATP synthase delta (OSCP) subunit


Domain annotation for each model (and alignments):
>> OSCP  ATP synthase delta (OSCP) subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0      0.44   7.9e+03      75      96 ..      18      39 ..       8      45 .. 0.57
   2 !   32.1   0.0   6.2e-12   1.1e-07      41     168 ..      82     216 ..      54     219 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.44
        OSCP 75 llaenkRlalLpeiaeefeell 96
                 l+  +R +++++ ++e  + +
  EFC38934.1 18 ALLSTQRATYFTDAFSESDKFA 39
                4555556666655555554444 PP

  == domain 2  score: 32.1 bits;  conditional E-value: 6.2e-12
        OSCP  41 ellsnpavsaeekkdlleelfke..klseavknflkllaenkRlalLpeiaeefeellaeargiveaeVtsavpLtdeqlekleaal.....akklgkk 132
                 +++++   + ++  ++l++++k+   + e+ + +l ++ +++ +++++ i+++f++l++++ +i+  ++t  +pL+ +  + l              k+
  EFC38934.1  82 SFFKKEGTPITQNNAALTKFLKDagVAPEVATDLLTTVYQRGQEGIFDTIVAQFNKLYNAHFQIAYGKLTLPQPLSTKYTTFLHLMKmaavgTLAPVKT 180
                 566666667777888888888887445778899*********************************************998876432111222222355 PP

        OSCP 133 kvkleekvdpsliGGvvvkvgdkviDgSvkgkLekl 168
                 kv++++ + ps +GG + +vg+  iD+S  + L k+
  EFC38934.1 181 KVNFTSDILPSDLGGWRADVGEDSIDKSFVTELGKI 216
                 799999999999*****************9999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       390  (0.0217525); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 1280.32
//
Query:       EFC38935.1  [L=610]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   2.3e-119  397.6   0.2   3.2e-119  397.1   0.2    1.2  1  CTP_synth_N    CTP synthase N-terminus
    3.7e-49  167.1   0.1    7.4e-49  166.1   0.1    1.5  1  GATase         Glutamine amidotransferase class-I
    4.1e-05   23.4   0.4     0.0039   17.0   0.2    2.7  2  Peptidase_C26  Peptidase C26
     0.0072   16.2   0.0      0.016   15.0   0.0    1.6  1  PRMT5          PRMT5 arginine-N-methyltransferase
  ------ inclusion threshold ------
      0.074   13.1   0.0        0.2   11.7   0.0    1.7  1  CbiA           CobQ/CobB/MinD/ParA nucleotide binding domain


Domain annotation for each model (and alignments):
>> CTP_synth_N  CTP synthase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  397.1   0.2    9e-123  3.2e-119       1     265 []       4     281 ..       4     281 .. 0.98

  Alignments for each domain:
  == domain 1  score: 397.1 bits;  conditional E-value: 9e-123
                  EEEEEEE--STTTTHHHHHHHHHHHHHCTT--EEEEEEE-SSSSSSTT--CCCC--EEE-TT--EEETHHHHHHHHHT----GGGEEEHHHHHHHHHH CS
  CTP_synth_N   1 kyilvtGGvvSglGkGiiaaslgallksrglkvtlikiDPYlnvdagtlsplehGEvfvlddGaetDlDlGnYeRfldikltkennittGkiyksvie 98 
                  ky+lv GGv+SglGkGiia+s+g+llk+ g +vt+ikiDPY+n+dagt+sp+ehGEv+vlddG+e+DlDlGnYeRfl+++l+++nn+ttGkiyksvie
   EFC38935.1   4 KYVLVIGGVISGLGKGIIASSVGRLLKEAGQNVTSIKIDPYINIDAGTMSPYEHGEVYVLDDGGEVDLDLGNYERFLNLRLHSDNNLTTGKIYKSVIE 101
                  8************************************************************************************************* PP

                  HHHTTTTTT----CCCHHHHHHHHHHHHHH.HC............T-SEEEEEE-S-TTSGGGHHHHHHHHHHHHHH-TTTEEEEEEEE--B-TTTSS CS
  CTP_synth_N  99 kerrGdylGktvqviphvtdeikeriekvakkv............eadvviveigGtvgdieslpfleairqlklelgkenvllihvtlvpvlkaage 184
                  kerrGdylGktvqv+phvt+ei+e+i++v+  +            ++dv+i+e+gGt+gdie++pf+ea+rq+++++g+en+++i+v+l p +++ +e
   EFC38935.1 102 KERRGDYLGKTVQVVPHVTNEIQEWIRRVSLVTtdvailekhpssNPDVCIIELGGTIGDIEGMPFIEALRQFQQKVGRENFCCIMVSLAPAITSDSE 199
                  ****************************997645789999998877**************************************************** PP

                  B-HHHHHHHHHHHHHHT---SEEEEEESS---HHHHHHHHHHCT--G.GGEEEEE--S-GGGHHHHHHHCTHHHHHHHHTT- CS
  CTP_synth_N 185 lktkptqhsvkelrslGiqpdiivcrsekeleeevkekialfcnvek.eavisvkdvesiyevpllleeqglaelileklkl 265
                  +ktkptq++v+elr++G +pd+iv+rse+ l+++v+eki +fc ve+ ++vi +++++++  vp ll++qgl +li+++l l
   EFC38935.1 200 QKTKPTQQCVRELRAVGFSPDFIVVRSEEVLQKAVREKIFNFCGVESvDHVIGCHNMRNLLAVPELLAQQGLGKLIQKRLGL 281
                  *********************************************97589****************************9976 PP

>> GATase  Glutamine amidotransferase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  166.1   0.1   2.1e-52   7.4e-49       3     189 ..     324     597 ..     322     598 .. 0.92

  Alignments for each domain:
  == domain 1  score: 166.1 bits;  conditional E-value: 2.1e-52
                 EESSTSTHHHHHHHHHHTT-EEEEEETTSHHHHH......................HHTHHSTSEEEEEEESSCTTTTTHHHHHHHHCTSTS-EEEETH CS
      GATase   3 iDnydsvtenlvhalvelgvkvevvpidasaeei......................lellknpdgilvsgGpgspgvegkieaikearenkiPiLGICL 79 
                  D+y s+ ++  h+++ lg k+e+v i+as++e                       ++llk+++gilv+gG g +g+egki+a+k+aren+iP+LGICL
  EFC38935.1 324 PDAYLSIQKAFQHSSLMLGEKIELVYIEASNLEPtectaedetssqssdtevystnWDLLKSCHGILVPGGYGIRGTEGKIAAVKYARENNIPYLGICL 422
                 69************************************************9988665579*************************************** PP

                 HHHHHHHHTTTEEE...................................EEECEEEEEEEEEEEETTT..........................CGGTT CS
      GATase  80 GmQllaiefgrkvv...................................kekekehhggtmrlgddet..........................allyg 117
                 GmQl++ ef+r+v                                    +e +k+h+ggtmrlg++ t                           +lyg
  EFC38935.1 423 GMQLAVVEFARNVLgysnatseefngeqeesekkhrkkrvdpknvivymPEISKTHLGGTMRLGSRTTifvnspvgddseienlegsllskskiFELYG 521
                 ***********7777777777777777777777777777778888899*9999************999**************************9**** PP

                 TTSEEEEEEEEEEEEESG...CHHHTTEEEEEEEETTE..EEEEEEEETTTEEEESSBTTSTTSTTHHHHHHHHHHH CS
      GATase 118 lknevierhrHryevnpk...elepaglevtaksedde..elmeiiekknpfvgvQFHPEststpegpellfnflik 189
                 +k++ +erhrHryevnp+   e+ ++gl++++++++ +  e++ei  +++ fv+vQ+HPE++s+ e+p+++f +l+k
  EFC38935.1 522 KKPRTNERHRHRYEVNPNlvpEFTKQGLIFVGQDTTRQrqEICEILTHNY-FVAVQYHPEFQSSLENPSPPFVGLVK 597
                 *********************************98875556666666666.*********************99886 PP

>> Peptidase_C26  Peptidase C26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.87   3.1e+03      54      70 ..     381     397 ..     372     402 .. 0.84
   2 !   17.0   0.2   1.1e-06    0.0039      95     216 .]     404     580 ..     400     580 .. 0.49

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.87
  Peptidase_C26  54 aildkldgllltGgqdv 70 
                    ++l++++g+l++Gg+ +
     EFC38935.1 381 DLLKSCHGILVPGGYGI 397
                    57899*********866 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 1.1e-06
  Peptidase_C26  95 laLiraalergvPilgiCrGlqllnvalGGtlyqdieeqsgltdhrehe...................................qsaashavkve. 154
                    +a ++ a e+++P lgiC+G+ql  v +  ++    +++s++ +  ++e                                   +         + 
     EFC38935.1 404 IAAVKYARENNIPYLGICLGMQLAVVEFARNVLGYSNATSEEFNGEQEEsekkhrkkrvdpknvivympeiskthlggtmrlgsR---------Tt 490
                    67789999****************9998877655444433333333333122222333444444444444443333333322220.........02 PP

  Peptidase_C26 155 .....................kgsllaellgseeievnslHhqaike........laeelrveAvae.DgviEaieseeakafvlgvQwHPE 216
                                         ++s + el+g ++ ++n  H+   +           ++l  + +++  +  E  e+ +++  +++vQ+HPE
     EFC38935.1 491 ifvnspvgddseienlegsllSKSKIFELYG-KKPRTNERHRHRYEVnpnlvpefTKQGLIFVGQDTtRQRQEICEILTHN-YFVAVQYHPE 580
                    2222333333333344233333333334445.5566665555544444455555555566666666555555555555544.5566666666 PP

>> PRMT5  PRMT5 arginine-N-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   4.6e-06     0.016     114     165 ..     122     177 ..      84     186 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 4.6e-06
                 HHHTTCCGCEEEES-CCCCCHCC..-ECEEEE---BTTBCCCSHH..HHHHCCGGG CS
       PRMT5 114 neekWeekveviksdmrelkaee..kvdllvsELLGSfgdnELsP..Ecldgvqkf 165
                 + ++W ++v+++++d+  l+++   + d+++ EL G +gd E  P  E+l ++q+ 
  EFC38935.1 122 EIQEWIRRVSLVTTDVAILEKHPssNPDVCIIELGGTIGDIEGMPfiEALRQFQQK 177
                 4679************99987654599***************99977788777765 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   5.5e-05       0.2       5      43 ..      11      49 ..       7     265 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5.5e-05
                ESSTTSSHHHHHHHHHHHHHHTT--EEEEEEEESSCCCC CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        CbiA  5 stkGGvGKTtlaanLaralarrglrVllvDaDpqannla 43
                +  +G GK  +a + +r+l+++g +V  ++ Dp  n +a
  EFC38935.1 11 GVISGLGKGIIASSVGRLLKEAGQNVTSIKIDPYINIDA 49
                5569*****************************998877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (610 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       632  (0.0352502); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.74u 0.32s 00:00:01.06 Elapsed: 00:00:00.51
# Mc/sec: 3614.05
//
Query:       EFC38936.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.9e-34  118.7   5.3      2e-33  116.0   5.3    2.0  1  Act-Frag_cataly  Actin-fragmin kinase, catalytic
     0.0039   17.0   0.3     0.0073   16.1   0.3    1.5  1  PI3_PI4_kinase   Phosphatidylinositol 3- and 4-kinase


Domain annotation for each model (and alignments):
>> Act-Frag_cataly  Actin-fragmin kinase, catalytic
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  116.0   5.3   2.2e-37     2e-33      21     282 .]      62     317 ..      43     317 .. 0.82

  Alignments for each domain:
  == domain 1  score: 116.0 bits;  conditional E-value: 2.2e-37
  Act-Frag_cataly  21 kidwkslssveksdsgssgvilletfngnkleaivlKssstiaqevyaykLakiLkvpipelrlleysnlEftel.......senll.katked 106
                       idw++++ v +s   +sg++++et++    + +v+K +stiaqe+y+ k+a+ L++++p+++l+ey  +  + +       ++ l  +  k +
       EFC38936.1  62 PIDWSNIQNVFLSSNQTSGILFVETQEK--DHVVVVKATSTIAQEIYGGKIAEFLGLKTPQVKLMEYRADFKNPIkkywadcKKYLKeFTVKYG 153
                      49************************98..899*********************************8754333345555553777774445667 PP

  Act-Frag_cataly 107 eslgd.rikseLekafllimeYvpgiklleelneyfsgeka....ekklkqLGkilafDifinNedrlple.iWdssgnaanillkdipdknes 194
                       s+++ +i +eL +af+l+me+++g ++l+++ + +s  k+    e+     G ++++Di+ nN drlpl  iW+ +gn++nil+     k + 
       EFC38936.1 154 MSVEQrKIEKELFRAFFLLMEFIEGATSLDDIMSDESIGKSllenEQVCEDFGGMIVLDIILNNCDRLPLDlIWNHEGNSSNILFS---PKLQR 244
                      7886527*********************99988777777778887888999***********************************...66666 PP

  Act-Frag_cataly 195 lfslnnsnidelndsafeifyaiDsrsiqrersylnklkelLvslfedlkstesellkkmrdlllkktkiklsesslvaiqkGIikgi 282
                      l+ +++  +       ++ +          +++y++k++++     e+    +   l ++ d+++++t++k+s+     i+kGI+k+i
       EFC38936.1 245 LVLIDQAFMA-----IINEGQ---------KQTYFKKIESFSKCCSEE-TLSNNPYLDQVVDYIYNCTGYKMSDQAKENIHKGILKSI 317
                      6655554444.....333333.........467789999986665566.7777889*****************************987 PP

>> PI3_PI4_kinase  Phosphatidylinositol 3- and 4-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.3   8.2e-07    0.0073      87     164 ..     128     227 ..      82     329 .. 0.65

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 8.2e-07
                     H......HHHHCHCHCCHHHHHCC.......HHHHHHTSSTTHHHHHHHHHSSSHHHHHHH.........HHHHHHHHHHHHHHHHHHT-TT--T CS
  PI3_PI4_kinase  87 s......lrvaldkkklkkekklk.......fekrtalkpksgllqeFvkkspsaeewlea.........rkqFvrslaklsvldyilgngDRhl 159
                     +      +++  d kk+ ke ++k       ++ +++l     ll eF++ ++s ++  +           +q ++++ +++vld+il+n+DR +
      EFC38936.1 128 AdfknpiKKYWADCKKYLKEFTVKygmsveqRKIEKELFRAFFLLMEFIEGATSLDDIMSDesigkslleNEQVCEDFGGMIVLDIILNNCDRLP 222
                     1333344555556666666666667777766777777778888888999999998877655777777888***********************66 PP

                     TTEEE CS
  PI3_PI4_kinase 160 dNilv 164
                       +  
      EFC38936.1 223 LDLIW 227
                     55554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       785  (0.0437838); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 2505.12
//
Query:       EFC38937.1  [L=362]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00044   20.3   0.5       0.39   10.8   0.2    2.8  2  DUF5595   Domain of unknown function (DUF5595)


Domain annotation for each model (and alignments):
>> DUF5595  Domain of unknown function (DUF5595)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.2   2.2e-05      0.39      28      53 ..     263     288 ..     258     308 .. 0.82
   2 !    6.7   0.0   0.00041       7.4      19      40 ..     315     338 ..     313     349 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 2.2e-05
     DUF5595  28 eDtFeeedaeleskLkelynvdeaql 53 
                  D+F++ d el + Lk +y++ +a +
  EFC38937.1 263 FDNFNDLDSELPVNLKSMYHIFSAFI 288
                 49******************988766 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.00041
     DUF5595  19 kcYekFmq..geDtFeeedaeles 40 
                 ++Y  Fm+  +eD+Fe+ ++ l++
  EFC38937.1 315 NTYIPFMKvmMEDQFEDIETVLKI 338
                 69*****7558******9988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2311.37
//
Query:       EFC38938.1  [L=445]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.7e-10   40.8   0.0    1.6e-09   37.6   0.0    2.3  2  GTP_EFTU     Elongation factor Tu GTP binding domain
    2.1e-08   34.4   0.0    5.2e-08   33.2   0.0    1.7  1  GTP_EFTU_D3  Elongation factor Tu C-terminal domain
    4.1e-08   33.5   0.2    9.1e-08   32.4   0.2    1.6  1  GTP_EFTU_D2  Elongation factor Tu domain 2
    0.00033   20.5   1.8     0.0007   19.5   1.8    1.5  1  GTP_EFTU_D4  Elongation factor Tu domain 4
     0.0055   16.6   0.0      0.012   15.5   0.0    1.5  1  RsgA_GTPase  RsgA GTPase
     0.0056   16.4   0.1      0.014   15.1   0.1    1.7  1  AAA_29       P-loop containing region of AAA domain
     0.0059   17.1   0.0      0.012   16.1   0.0    1.6  1  ABC_tran     ABC transporter
  ------ inclusion threshold ------
      0.029   14.5   0.1       0.11   12.5   0.1    2.0  1  MMR_HSR1     50S ribosome-binding GTPase
      0.083   12.8   0.4         12    5.9   0.0    3.0  3  DUF3198      Protein of unknown function (DUF3198)
       0.12   12.7   0.0       0.22   11.8   0.0    1.4  1  AAA_22       AAA domain
       0.13   12.0   0.6        6.7    6.5   0.2    3.2  3  PduV-EutP    Ethanolamine utilisation - propanediol utilisati
       0.15   12.0   0.9       0.29   11.1   0.9    1.7  1  NACHT        NACHT domain
       0.17   12.3   0.0       0.29   11.5   0.0    1.3  1  AAA_16       AAA ATPase domain


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.6   0.0   1.2e-12   1.6e-09       4      87 ..       7     100 ..       4     107 .. 0.86
   2 ?    1.1   0.0      0.17   2.4e+02     161     186 ..     108     133 ..      93     153 .. 0.70

  Alignments for each domain:
  == domain 1  score: 37.6 bits;  conditional E-value: 1.2e-12
                 EEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH..HHHST.............HCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHHH CS
    GTP_EFTU   4 rnigiighvDhGKtTLtdrLlyktgaiskkgeka..eeerv.............lDtlkeErergiTiksaaisleketkkylinliDtPGHvdFskev 87 
                  +i++ig + +GK+TL+++Lly+ g i +++ ++  +  ++             + ++ +Ere   T + +  ++e  tk+y +nliDtP  + F+k+v
  EFC38938.1   7 HTISLIGQTGSGKSTLLGQLLYQMGYILDEQLEEisK--TAdklgkpnckysflVNSTRKERECASTSQLSFRQVE--TKNYFCNLIDTPE-QVFVKTV 100
                 6899***********************9988888542..2346799999****9**********************..************3.3466655 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.17
                 HHTTTTTEEEEEEBTTTTBTHHHHHH CS
    GTP_EFTU 161 gekgekevpvvfgSalkgegvktlle 186
                 +  g++ v ++++Sa+ g+++ +l +
  EFC38938.1 108 KRTGSSSVDIIPISAYCGDNIVELSD 133
                 33344689***********9986654 PP

>> GTP_EFTU_D3  Elongation factor Tu C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.2   0.0   3.8e-11   5.2e-08       8     111 ..     256     351 ..     250     352 .. 0.88

  Alignments for each domain:
  == domain 1  score: 33.2 bits;  conditional E-value: 3.8e-11
                  EEEEEEESSS..SS-BSTT-EEEEESSS-EEEEEEEEEEECCSSTTSB-BSS-SSCCSTT-CEEEEEEECCEEEE--TTTHCCCCEEEEECTTCEEEE CS
  GTP_EFTU_D3   8 feAqvyilekerhtpitagYrpvlyirtadvtgkvveLlskldkktekvsekkpefvkpGdnvivevelikpialekgseypqlGrFaiReggrTvaa 105
                  feA+++ + +  ++ i+ +Y+p + +++++ ++k v+++++  ++    +e  p f+k     +ve+el k   l++      + rF iR+ ++ ++ 
   EFC38938.1 256 FEANILNIDH--PKGIHPNYQPTIQLQATQAKCKLVTIKESSCHRI--LKEYFPPFIKRNYLGVVECELDKACYLDTDA----FCRFFIRDFRKVIGF 345
                  7888777777..**************************66655444..33478***********************999....99************* PP

                  EEEEEE CS
  GTP_EFTU_D3 106 Gvvtei 111
                  G +t++
   EFC38938.1 346 GAITRV 351
                  ***987 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.4   0.2   6.6e-11   9.1e-08       1      73 [.     175     242 ..     175     243 .. 0.92

  Alignments for each domain:
  == domain 1  score: 32.4 bits;  conditional E-value: 6.6e-11
                  EEEEEEEEEESEEETTEEEEEECTCTTSEE.EEEEEEEEEEETEEESEEETTSEEEEEEEESSCCSGSSTTCEE CS
  GTP_EFTU_D2   1 GtvalgrvysGtlkkGdevrilgndtskke.ivtrissletfhededeavaganaGvivaikgledaiivGdtl 73 
                  Gtv++g+v+ G+lk   ++++    +   + +  ri s+e f ++++ea  g+ + ++++ +  ++ i+ Gd++
   EFC38938.1 175 GTVVYGKVVAGILKMESKIVLAN--S---NiENARIASIESFGKRLEEAKSGQLVAINLRNVLHSS-IKSGDVI 242
                  9********************44..3...2345*********************************.*****98 PP

>> GTP_EFTU_D4  Elongation factor Tu domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   1.8   5.1e-07    0.0007      19      85 ..     177     242 ..     168     244 .. 0.86

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 5.1e-07
                  EEEEEEEEEEEEETT-EEEETTE..EEEEEEEEEETTEEESEEETT-EEEEEEESS-TTTS--TT-EE CS
  GTP_EFTU_D4  19 aivGvevlgGvikpgvklikedGr.evGeilqiqdkgkkleeakaGqevaisiegkivGrqikegdil 85 
                  ++ G +v++G++k + k++ ++ + e  +i++i++ gk+leeak Gq vai +++     +ik gd++
   EFC38938.1 177 VVYG-KVVAGILKMESKIVLANSNiENARIASIESFGKRLEEAKSGQLVAINLRNVL-HSSIKSGDVI 242
                  6778.9********999987765326789************************9755.8999999986 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   8.7e-06     0.012     100     135 ..       7      46 ..       3      63 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 8.7e-06
                  SEEEEECSTTSSHHHHHHHHCTT....-----S------- CS
  RsgA_GTPase 100 ktsvlvGqSGvGKStLinallpe....lelktgevseklg 135
                  +t+ l+Gq+G GKStL+ +ll +    l+ + +e+s++ +
   EFC38938.1   7 HTISLIGQTGSGKSTLLGQLLYQmgyiLDEQLEEISKTAD 46 
                  6889****************99844545788888887654 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.1     1e-05     0.014      24      39 ..       8      23 ..       1      29 [. 0.83

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1e-05
      AAA_29 24 atlltGpsGsGKSTll 39
                ++ l+G++GsGKSTll
  EFC38938.1  8 TISLIGQTGSGKSTLL 23
                5679***********8 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0     9e-06     0.012      11      33 ..       6      28 ..       4     114 .. 0.73

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 9e-06
                TSEEEEEESTTSSHHHHHHHHTT CS
                xxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran 11 gekvaivGenGaGKStLlkllag 33
                 +++ ++G++G+GKStLl  l+ 
  EFC38938.1  6 THTISLIGQTGSGKSTLLGQLLY 28
                67899************966544 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   8.3e-05      0.11       2      54 ..       9      92 ..       8     118 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8.3e-05
                EEEEESTTSSHHHHHHHHH...........TSTEEESSSTTSSSSEEEEEEEETTEE....................EEEEECG CS
    MMR_HSR1  2 vaivGrpNvGKStLinalt...........gekaivsdkpgtTrdinegrvklkgke....................ielvDtp 54
                + ++G++ +GKStL+ +l+           +e ++++dk g+      + v+  +ke                    ++l+Dtp
  EFC38938.1  9 ISLIGQTGSGKSTLLGQLLyqmgyildeqlEEISKTADKLGKPNCKYSFLVNSTRKErecastsqlsfrqvetknyfCNLIDTP 92
                789***************955555554443234455555444444433333311111233333344444444444447777777 PP

>> DUF3198  Protein of unknown function (DUF3198)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       3.2   4.4e+03      24      33 ..      37      46 ..      36      49 .. 0.75
   2 ?    5.9   0.0    0.0086        12      10      35 ..      89     113 ..      81     114 .. 0.81
   3 ?    3.4   0.0      0.05        70      34      45 ..     209     220 ..     208     222 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.2
                HHHHHHHHH- CS
     DUF3198 24 eLekiarklG 33
                +Le+i++  +
  EFC38938.1 37 QLEEISKTAD 46
                6999998765 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0086
                 HHS--HHHHHHHHHHHHHHHHHH-SH CS
     DUF3198  10 InSdSKstFvknlkeLekiarklGss 35 
                 I ++  ++Fvk + eL ki ++ Gss
  EFC38938.1  89 IDTP-EQVFVKTVSELSKILKRTGSS 113
                 5555.489**************9986 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.05
                 SHHHHHHHHHHH CS
     DUF3198  34 ssYqqrLeeake 45 
                 +s+++rLeeak+
  EFC38938.1 209 ESFGKRLEEAKS 220
                 69*********6 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   0.00016      0.22       8      28 ..       9      29 ..       4      75 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00016
      AAA_22  8 lvvtGesGtGKTtllrrlleq 28
                + ++G++G+GK+tll +ll+q
  EFC38938.1  9 ISLIGQTGSGKSTLLGQLLYQ 29
                679************999987 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.2    0.0048       6.7       3      21 ..       8      26 ..       6      50 .. 0.80
   2 ?    0.3   0.0      0.38   5.2e+02      24      67 ..      72     118 ..      66     134 .. 0.60
   3 ?    0.8   0.0      0.27   3.7e+02      51      96 ..     271     316 ..     253     356 .. 0.78

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0048
   PduV-EutP  3 killiGkvgsGKttLtqal 21
                 i liG++gsGK tL  +l
  EFC38938.1  8 TISLIGQTGSGKSTLLGQL 26
                5789**********97665 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.38
   PduV-EutP  24 eelkYkktqaiefsdeviDtPGe.ylen.rklysalivt.saeadvi 67 
                  +l++++  + ++  ++iDtP + +++   +l++ l+ t s ++d+i
  EFC38938.1  72 SQLSFRQVETKNYFCNLIDTPEQvFVKTvSELSKILKRTgSSSVDII 118
                 56777788888888888999977233321234444433324445555 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.27
   PduV-EutP  51 rklysalivtsaeadvialvqdateeesvfppgfasvfnkeviGii 96 
                  ++  +++  +++a+   +  + ++ + ++ + f  +++++ +G++
  EFC38938.1 271 PNYQPTIQLQATQAKCKLVTIKESSCHRILKEYFPPFIKRNYLGVV 316
                 4566666666666666666666667778888999999999999998 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.9   0.00021      0.29       2      23 ..       8      29 ..       7     154 .. 0.96

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00021
                CEEEEC-TTTCHHHHHHHHHHH CS
       NACHT  2 lvilqGeaGsGKTtLlqklala 23
                ++ l G+ GsGK+tLl +l  +
  EFC38938.1  8 TISLIGQTGSGKSTLLGQLLYQ 29
                7899************999765 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00021      0.29      25      46 ..       7      28 ..       3      75 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00021
      AAA_16 25 elvllsGesGvGKsslvrellr 46
                + + l+G+ G+GKs+l+ +ll 
  EFC38938.1  7 HTISLIGQTGSGKSTLLGQLLY 28
                67899************99884 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       500  (0.0278878); expected 358.6 (0.02)
Passed bias filter:                      435  (0.0242624); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 2707.31
//
Query:       EFC38939.1  [L=182]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-38  132.7   0.1    1.6e-38  132.4   0.1    1.0  1  Flavodoxin_2  Flavodoxin-like fold
    0.00016   21.4   0.0    0.00023   21.0   0.0    1.3  1  FMN_red       NADPH-dependent FMN reductase
  ------ inclusion threshold ------
       0.12   12.6   3.8         21    5.3   2.0    3.8  4  FBA_2         F-box associated


Domain annotation for each model (and alignments):
>> Flavodoxin_2  Flavodoxin-like fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  132.4   0.1   2.7e-42   1.6e-38       2     196 ..       3     173 ..       2     175 .. 0.89

  Alignments for each domain:
  == domain 1  score: 132.4 bits;  conditional E-value: 2.7e-42
                   EEEEEE--TTGGCCHHHCHHHHHHHHHCCCTTTEEEEEEHHCCT-----CCCCHCCHHHHTT.CHHHHHHHHHHHHCSSEEEEEEE-BTTB--HHHH CS
  Flavodoxin_2   2 kiLiinahprpeksfssalaqafvealekagphevtvrdLyadflpvlttrdlaaklayeek.padveseqiekllaadaivlqfPlwwfgvPailK 97 
                   k+L+ + h r+e   ss++++++++al + + + +++++++++f              +e++ + d  s+  ++ll+ad+i++qfP+ w+++Pa +K
    EFC38939.1   3 KTLVFFFHERFE---SSQANRSMIKALSTLD-N-IEIVNMHQIF--------------TENGnKFDSNSDI-QRLLNADRIIFQFPIQWYSMPAFMK 79 
                   8999******94...689***********98.4.********83..............3444259999999.************************* PP

                   HHHHHHS-TTTSC.EETTCSSCCCCTTTTSEEEEEEEESS-GGGSSTTSSS-S-HHHHHHHHHHHHHHTT-EEEEEEEEESCTCCCHHHHHHHHHHH CS
  Flavodoxin_2  98 gwiDrvltagfaf.yteeggegrgggLkgkkalvivttGgpeesyqerglegaamdellpplrgilgfiGikdvepvlvegvagaedeealaealer 193
                   +wiD+ +t+ ++  y+eeg      +++gkk +++vt+G+ ee+y+++g++  ++d+ll+pl++ ++ + +++ ep++ + + ++++ e+l+e +e+
    EFC38939.1  80 QWIDETFTRMYYIrYGEEG-----LKMEGKKFMISVTAGNFEEAYTPQGQNLIPLDDLLNPLKALAHRCKLQWSEPFISYRA-NKKSVEELEETAEQ 170
                   ***********99565555.....3555*****************************************************6.55555559999999 PP

                   HHH CS
  Flavodoxin_2 194 lee 196
                   +++
    EFC38939.1 171 YRQ 173
                   987 PP

>> FMN_red  NADPH-dependent FMN reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   3.8e-08   0.00023      59     119 ..      46     113 ..       2     124 .. 0.70

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 3.8e-08
                 GSHHHHHHHHHHHH-SCEEEEEEECTTCE-HHHHHHHHCHT-........SSCHCCTT-EEEEEEE-S CS
     FMN_red  59 tsddvaellekiaaadaliivtPeYngsysgllKnalDrlsr.......trgkkelrgKpvalvavgg 119
                 ++ d ++ ++++ +ad +i+  P+ ++s+++ +K  +D +           ++  ++gK +++ +++g
  EFC38939.1  46 NKFDSNSDIQRLLNADRIIFQFPIQWYSMPAFMKQWIDETFTrmyyiryGEEGLKMEGKKFMISVTAG 113
                 44555666899***************************987677777554444455566666665555 PP

>> FBA_2  F-box associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.7     0.039   2.4e+02      22      50 ..      28      58 ..       5      60 .. 0.77
   2 ?    5.3   2.0    0.0036        21      30      65 ..      59      93 ..      29      94 .. 0.65
   3 ?    1.6   0.0     0.053   3.1e+02       7      28 ..     112     134 ..     109     149 .. 0.80
   4 ?    1.0   0.0     0.079   4.7e+02      42      55 ..     167     180 ..     155     182 .] 0.72

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.039
       FBA_2 22 tLddLLiiNsksleldnss.l.sskdlNrFL 50
                tLd++ i+N  ++  +n + + s+ d+ r L
  EFC38939.1 28 TLDNIEIVNMHQIFTENGNkFdSNSDIQRLL 58
                8999999999999988866697778888766 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0036
       FBA_2 30 NsksleldnsslsskdlNrFLKhWikgsnprLeyls 65
                N+ ++ ++ +      +  F K Wi    +r+ y++
  EFC38939.1 59 NADRIIFQFPI-QWYSMPAFMKQWIDETFTRMYYIR 93
                44556654332.2245788*************9986 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.053
       FBA_2   7 iqnfdeltik.dsswltLddLLi 28 
                   nf+e +    ++ + LddLL+
  EFC38939.1 112 AGNFEEAYTPqGQNLIPLDDLLN 134
                 5789988855555668*****95 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.079
       FBA_2  42 sskdlNrFLKhWik 55 
                 + ++  +F  +W+ 
  EFC38939.1 167 TAEQYRQFVSKWME 180
                 568899******97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       749  (0.0417759); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1195.43
//
Query:       EFC38940.1  [L=134]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (134 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       490  (0.02733); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.28s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 859.15
//
Query:       EFC38941.1  [L=350]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       647  (0.0360868); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 2201.24
//
Query:       EFC38942.1  [L=346]
Description: hypothetical protein NAEGRDRAFT_59377 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       479  (0.0267165); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.29s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2361.42
//
Query:       EFC38943.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.4e-22   78.1   0.4    8.2e-22   77.3   0.4    1.5  1  CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) a
    3.1e-06   27.6   0.1    3.1e-06   27.6   0.1    2.1  2  Histone        Core histone H2A/H2B/H3/H4
     0.0052   16.9   0.0     0.0079   16.3   0.0    1.3  1  CENP-T_C       Centromere kinetochore component CENP-T histon
  ------ inclusion threshold ------
      0.012   15.4   1.9      0.012   15.4   1.9    1.9  2  PAN_3          PAN-like domain
      0.035   14.4   0.7       0.07   13.5   0.7    1.5  1  DUF3362        Domain of unknown function (DUF3362)


Domain annotation for each model (and alignments):
>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.3   0.4   2.3e-25   8.2e-22       2      65 .]      83     150 ..      82     150 .. 0.91

  Alignments for each domain:
  == domain 1  score: 77.3 bits;  conditional E-value: 2.3e-25
                    XXXHHHHHHHHHCC.TTXS-...B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF   2 eLPiarvkkImksd.pdark...iakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65 
                     LP a++++Imk++ +  +k   i+k+Ake+++ecv+efi ++++eA+++c +ekrKt+++e+++ A+
     EFC38943.1  83 LLPYANIERIMKKTvEMFNKsakISKEAKECMQECVTEFICFVTGEASDLCVEEKRKTVAGEDVLNAL 150
                    59**********99765444455*****************************************9986 PP

>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   0.1   8.5e-10   3.1e-06      57     128 ..      79     150 ..      77     153 .. 0.92
   2 ?   -0.8   1.3       0.5   1.8e+03      18      41 ..     176     190 ..     161     202 .. 0.38

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 8.5e-10
                 XXSXXSXHHHHHHHHHHHH.TTSSSXEEXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXSEEXHHHHHHHH CS
     Histone  57 stdlliqklpfaRvvreivksekedlrisaeavlalqealEallvelfeeAnllakhaKRvTitpkDiqlAr 128
                 + d+l + + ++R++++ v+ + ++ +is+ea +++qe +  ++  ++ eA+ l+ + KR+T+  +D+  A+
  EFC38943.1  79 EQDRLLPYANIERIMKKTVEMFNKSAKISKEAKECMQECVTEFICFVTGEASDLCVEEKRKTVAGEDVLNAL 150
                 4566677799*********************************************************98775 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.5
                 XXXXXXXXHTTS-SSSSB--TTT- CS
     Histone  18 ekkvsakkerkasskskkkkkrry 41 
                 +kk s ++++         kk+ +
  EFC38943.1 176 DKKGSGSNKN---------KKKSS 190
                 2222222222.........11111 PP

>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.2e-06    0.0079       4      74 ..      80     150 ..      77     170 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.2e-06
    CENP-T_C   4 evpslPaavvkklakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilLm 74 
                 +   lP a + ++ k+  +   ++ak++kea + ++++  +f+  v+ +        +RKt+  +Dv+  +
  EFC38943.1  80 QDRLLPYANIERIMKKTVEMFNKSAKISKEAKECMQECVTEFICFVTGEASDLCVEEKRKTVAGEDVLNAL 150
                 45569************99999*********************************************8655 PP

>> PAN_3  PAN-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   1.9   3.4e-06     0.012       8      46 ..      97     134 ..      92     135 .. 0.86
   2 ?   -3.0   0.1       1.9   6.9e+03      22      28 ..     162     168 ..     156     175 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3.4e-06
       PAN_3   8 pedlystssttseswddCvqkCledstCilayknsenCt 46 
                 +e  ++ s ++s++ ++C+q+C  +  C++  + s+ C+
  EFC38943.1  97 VEM-FNKSAKISKEAKECMQECVTEFICFVTGEASDLCV 134
                 344.59999*********************999998885 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.9
       PAN_3  22 wddCvqk 28 
                 +++C++k
  EFC38943.1 162 LKECLTK 168
                 5677766 PP

>> DUF3362  Domain of unknown function (DUF3362)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.7   1.9e-05      0.07      64     114 ..     148     199 ..     144     203 .] 0.77

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.9e-05
     DUF3362  64 eALkkmGredLiGngkkhLiptfqpk.vdgkdsrqsarrknskagkdaakra 114
                 +AL+k G e+  G  k++L + +++  +d k+s +++++k+s++g+++ +++
  EFC38943.1 148 NALEKLGFENYCGALKECLTKHRESIkNDKKGSGSNKNKKKSSKGGKNNNNK 199
                 8********************9998856776666677777777666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1555  (0.086731); expected 358.6 (0.02)
Passed bias filter:                      595  (0.0331865); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1311.14
//
Query:       EFC38944.1  [L=855]
Description: leucyl-tRNA synthetase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.1e-07   31.9   1.0    3.5e-07   30.3   0.5    2.1  2  Anticodon_1  Anticodon-binding domain of tRNA


Domain annotation for each model (and alignments):
>> Anticodon_1  Anticodon-binding domain of tRNA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   0.5   1.9e-11   3.5e-07      17     120 ..     653     770 ..     645     800 .. 0.65
   2 ?   -2.1   0.0      0.19   3.4e+03      28      51 ..     812     834 ..     794     845 .. 0.69

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 1.9e-11
  Anticodon_1  17 eayeeyrfnkaasalyeffwndlcdwylelvkprlysesaedkraaqevllevletllrllaPfmPfitEelwqreeeelgkkesi.mlaewpe.kae 112
                   +y+e++++ a+++ ++  +  + + y++  k+ +  + + +      ++  +l++ lr+l+P++P ++ ++w   ++ lg k+si ++++ p  +++
   EFC38944.1 653 SYYAEFNIRYAFNDGWYTAQMVF-KEYVQR-KNFI--KRKPNT----LLINNFLKNQLRILHPIIPAFASYCW---TDILGIKDSIlCYENIPLpDPK 739
                  57889999999999998644444.667666.3333..322233....7899**********************...4666999888455669987887 PP

  Anticodon_1 113 elekel..e.....................e 120
                  +l  ++                        +
   EFC38944.1 740 YLLSNHliRavlpksklrkrkystaritvcD 770
                  7733332212333444555555555555554 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.19
  Anticodon_1  28 asalyeffwndlcdwylelvkprl 51 
                  ++ ++   + +lc  y el  +++
   EFC38944.1 812 IKTIMRY-MSALCELYKELGSDIF 834
                  4556664.5568999999977776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (855 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       768  (0.0428356); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.30s 00:00:01.05 Elapsed: 00:00:00.48
# Mc/sec: 5307.38
//
Query:       EFC38945.1  [L=434]
Description: LRR_RI domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.5e-23   80.1  35.1      0.018   15.0   1.1   12.8 13  LRR_6       Leucine Rich repeat
    1.2e-15   57.0  39.4    0.00036   20.2   0.3    5.8  8  LRR_8       Leucine rich repeat
    1.7e-14   53.7  53.9      0.059   13.8   0.2    8.7 10  LRR_4       Leucine Rich repeats (2 copies)
    2.7e-05   23.7  13.2       0.16   11.5   0.0    4.3  5  LRR_9       Leucine-rich repeat
     0.0024   17.3   2.2       0.12   11.8   0.4    2.4  2  Rtf2        Rtf2 RING-finger
     0.0052   16.7   0.8      0.011   15.7   0.8    1.4  1  F-box-like  F-box-like
  ------ inclusion threshold ------
       0.14   12.8  26.0         16    6.5   0.1    9.6 10  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.0   0.00016      0.42       3      24 .]     118     140 ..     118     140 .. 0.94
   2 !   11.3   0.1   0.00011      0.29       4      23 ..     144     163 ..     141     164 .. 0.91
   3 !   10.9   0.1   0.00015      0.37       5      23 ..     169     187 ..     166     188 .. 0.90
   4 ?    0.6   0.0      0.31     8e+02       3      18 ..     191     206 ..     189     208 .. 0.87
   5 ?   -0.0   0.0      0.48   1.2e+03       5      23 ..     217     235 ..     215     236 .. 0.86
   6 !   10.1   0.1   0.00027       0.7       5      24 .]     241     260 ..     238     260 .. 0.92
   7 !   15.0   1.1   7.2e-06     0.018       4      24 .]     264     284 ..     261     284 .. 0.90
   8 ?    1.7   0.0      0.13   3.4e+02       5      24 .]     289     308 ..     286     308 .. 0.86
   9 !    9.4   0.1   0.00045       1.2       3      23 ..     311     331 ..     309     331 .. 0.91
  10 !    8.2   0.3    0.0011       2.9       4      21 ..     336     353 ..     333     356 .. 0.87
  11 ?    4.5   0.0     0.017        44      12      24 .]     367     380 ..     359     380 .. 0.84
  12 !    9.6   0.1   0.00039         1       3      20 ..     383     400 ..     381     403 .. 0.85
  13 ?    1.0   0.0      0.23     6e+02       2      13 ..     406     417 ..     405     418 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00016
       LRR_6   3 thLteLdLsgNd.IgDeGaeaLa 24 
                 ++L+ L++ +N+ +gD Gae+++
  EFC38945.1 118 PNLKRLEIGDNQqFGDCGAESIS 140
                 58******************996 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00011
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt+L++ +++I+ +Gae +
  EFC38945.1 144 TLTSLNVLDCGITSKGAEFI 163
                 9****************976 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 0.00015
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++  N+I D+G++ +
  EFC38945.1 169 LTYLNIGNNKIMDSGMKFI 187
                 9**************9976 PP

  == domain 4  score: 0.6 bits;  conditional E-value: 0.31
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 ++L  L++ + +I+ e
  EFC38945.1 191 SSLNVLQIGSTEITSE 206
                 799*********9987 PP

  == domain 5  score: -0.0 bits;  conditional E-value: 0.48
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++ +N ++ e a+++
  EFC38945.1 217 LTSLSIYSNPVTIEDAKSI 235
                 99****9999998888887 PP

  == domain 6  score: 10.1 bits;  conditional E-value: 0.00027
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L++L++s  +I+ eG++ L+
  EFC38945.1 241 LKSLNISNTGISVEGLKYLS 260
                 9***************9885 PP

  == domain 7  score: 15.0 bits;  conditional E-value: 7.2e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt L+L+ N+I++eG+ +++
  EFC38945.1 264 LLTNLSLAKNNITNEGLLSIS 284
                 69***************9986 PP

  == domain 8  score: 1.7 bits;  conditional E-value: 0.13
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 +t+L L++N I+ +Ga+ L+
  EFC38945.1 289 ITKLFLQHNVIDCDGAQLLS 308
                 577889*********99885 PP

  == domain 9  score: 9.4 bits;  conditional E-value: 0.00045
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 t+L+ L++s  +I+ eG++ +
  EFC38945.1 311 TNLRLLNISQTKITTEGIKHI 331
                 89***************9976 PP

  == domain 10  score: 8.2 bits;  conditional E-value: 0.0011
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                 ++t+L++s N+++De ++
  EFC38945.1 336 NITSLNISINQLNDEALK 353
                 79*************887 PP

  == domain 11  score: 4.5 bits;  conditional E-value: 0.017
       LRR_6  12 gNd.IgDeGaeaLa 24 
                 +N+ ++ eGa+ ++
  EFC38945.1 367 HNNkLTSEGAKHIS 380
                 5666*******986 PP

  == domain 12  score: 9.6 bits;  conditional E-value: 0.00039
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                 ++LteL++s+N +  eGa
  EFC38945.1 383 NNLTELNISSNPVRIEGA 400
                 79*********9887776 PP

  == domain 13  score: 1.0 bits;  conditional E-value: 0.23
       LRR_6   2 nthLteLdLsgN 13 
                  t+L+  ++s +
  EFC38945.1 406 MTTLKIINVSNC 417
                 58********99 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0     0.001       2.6      13      56 ..     105     150 ..      94     155 .. 0.81
   2 !   15.6   0.9   3.8e-06    0.0097       2      59 ..     144     201 ..     143     203 .. 0.87
   3 !   20.2   0.3   1.4e-07   0.00036       2      60 ..     168     226 ..     167     227 .. 0.95
   4 !   13.2   0.3   2.3e-05     0.058       2      60 ..     192     250 ..     191     251 .. 0.92
   5 !   16.7   6.8   1.8e-06    0.0045       2      61 .]     240     299 ..     239     299 .. 0.97
   6 !   20.0   4.6   1.7e-07   0.00044       2      61 .]     288     347 ..     287     347 .. 0.96
   7 !   16.1   9.5   2.7e-06     0.007       2      60 ..     336     394 ..     335     395 .. 0.97
   8 !   13.4   5.8   1.9e-05     0.049       2      59 ..     360     417 ..     359     418 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.001
                 -SEE-TTSSTT.-TT--EEE--SS.---GGGGGGGTT--S-.EEE- CS
       LRR_8  13 ltslddeaFkg.lsnLkvLdLsnN.llttlspgafsgLpsLrsLdL 56 
                 + s++ e  ++ ++nLk L++++N +     ++++s  + L+sL++
  EFC38945.1 105 IDSINAEIISKsFPNLKRLEIGDNqQFGDCGAESISKIKTLTSLNV 150
                 66777777766699**********9999999999999999999986 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 3.8e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +LtsL++ +  +ts + e+   l++L++L+++nN++     + +  L+sL  L + ++
  EFC38945.1 144 TLTSLNVLDCGITSKGAEFIGLLNGLTYLNIGNNKIMDSGMKFIGKLSSLNVLQIGST 201
                 6999999999999999999999999999999999999999999999999999988765 PP

  == domain 3  score: 20.2 bits;  conditional E-value: 1.4e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+L++ nN++ + + ++  +ls+L+vL++++ ++t+ s +   +++ L+sL + +N+
  EFC38945.1 168 GLTYLNIGNNKIMDSGMKFIGKLSSLNVLQIGSTEITSESFKLVGCMKGLTSLSIYSNP 226
                 69************************************9999***********998886 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 2.3e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +L++L++ ++ +ts + +    +++L++L++ +N  t  +++++s+ + L+sL++s++ 
  EFC38945.1 192 SLNVLQIGSTEITSESFKLVGCMKGLTSLSIYSNPVTIEDAKSISSIHGLKSLNISNTG 250
                 7899999999999999999999**********************************986 PP

  == domain 5  score: 16.7 bits;  conditional E-value: 1.8e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+sL++sn+ +++ + +  + l+ L+ L+L  N++t     ++s+++++++L L++N +
  EFC38945.1 240 GLKSLNISNTGISVEGLKYLSALTLLTNLSLAKNNITNEGLLSISQMKQITKLFLQHNVI 299
                 69************************************9999****************65 PP

  == domain 6  score: 20.0 bits;  conditional E-value: 1.7e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + t+L L++N +   + +  ++++nL+ L++s+ ++tt   + + +L++++sL++s N+L
  EFC38945.1 288 QITKLFLQHNVIDCDGAQLLSTMTNLRLLNISQTKITTEGIKHITSLKNITSLNISINQL 347
                 679***********************************999***************9998 PP

  == domain 7  score: 16.1 bits;  conditional E-value: 2.7e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 n tsL++s N+l++   +  +++++L+ L+  nN+lt+  ++ +s+L++L++L++s+N+
  EFC38945.1 336 NITSLNISINQLNDEALKLVSSMNQLTNLSTHNNKLTSEGAKHISQLNNLTELNISSNP 394
                 789*******************************************************7 PP

  == domain 8  score: 13.4 bits;  conditional E-value: 1.9e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+L+ +nN+lts + +  ++l+nL++L++s+N  +   ++ + +++ L+ +++s++
  EFC38945.1 360 QLTNLSTHNNKLTSEGAKHISQLNNLTELNISSNPVRIEGANYLNQMTTLKIINVSNC 417
                 69999999999***********************888888888888888888888887 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0    0.0032       8.2      15      37 ..     107     132 ..     103     136 .. 0.70
   2 !    7.9   0.2    0.0017       4.2       1      32 [.     118     154 ..     118     158 .. 0.74
   3 !   11.5   0.9   0.00013      0.33       2      36 ..     144     179 ..     143     183 .. 0.81
   4 !   13.2   0.5   3.6e-05     0.092       3      37 ..     169     204 ..     167     209 .. 0.82
   5 !   12.2   0.0   7.5e-05      0.19       2      36 ..     192     227 ..     191     237 .. 0.86
   6 !   13.8   0.2   2.3e-05     0.059       2      42 ..     216     256 ..     215     258 .. 0.79
   7 !   12.1   3.6   8.1e-05      0.21       2      36 ..     240     275 ..     239     277 .. 0.80
   8 !   13.2   3.3   3.5e-05     0.089       3      33 ..     265     297 ..     263     309 .. 0.85
   9 !   10.5   8.8   0.00025      0.65       1      38 [.     311     349 ..     311     367 .. 0.83
  10 !    7.0  12.2    0.0031         8       5      34 ..     363     401 ..     359     432 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0032
                 E-S-..HHH.-TT--EEE-.-S---- CS
       LRR_4  15 dipl..lek.lpnLkeLdLsgNnlit 37 
                 +i+   ++k +pnLk L + +N + +
  EFC38945.1 107 SINAeiISKsFPNLKRLEIGDNQQFG 132
                 5555444455*********7786655 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0017
                 SS--EEE--SS-.........--E-S-HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNq.........ltdiplleklpnLkeLdLsg 32 
                 pnL+ L +++Nq         +++i     l++L +Ld+ g
  EFC38945.1 118 PNLKRLEIGDNQqfgdcgaesISKIKT---LTSLNVLDC-G 154
                 89*******996666666666666555...888988888.4 PP

  == domain 3  score: 11.5 bits;  conditional E-value: 0.00013
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                  L++L+  ++ +t+ +  + + l  L++L++ gNn+i
  EFC38945.1 144 TLTSLNVLDCGITSKGAeFIGlLNGLTYLNI-GNNKI 179
                 68999999999**755578895666******.99998 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 3.6e-05
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 L++L+++nN++ d +   ++kl +L +L + g + it
  EFC38945.1 169 LTYLNIGNNKIMDSGMkfIGKLSSLNVLQI-GSTEIT 204
                 9************88895557*******99.654665 PP

  == domain 5  score: 12.2 bits;  conditional E-value: 7.5e-05
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 +L vL ++++ +t+ ++ l + ++ L++L++ +N ++
  EFC38945.1 192 SLNVLQIGSTEITSESFkLVGcMKGLTSLSIYSN-PV 227
                 7999**********99999988*********777.55 PP

  == domain 6  score: 13.8 bits;  conditional E-value: 2.3e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGG CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeL 42 
                  L++L++ +N +t  +   ++++  Lk+L++ +N+ i ++++L
  EFC38945.1 216 GLTSLSIYSNPVTIEDAksISSIHGLKSLNI-SNTGI-SVEGL 256
                 79*********99444465557999******.77788.77776 PP

  == domain 7  score: 12.1 bits;  conditional E-value: 8.1e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                  L++L++sn+ ++  +l  l+ l+ L+ L+L  N +i
  EFC38945.1 240 GLKSLNISNTGISVEGLkyLSALTLLTNLSLAKN-NI 275
                 69*********99655566557*********888.34 PP

  == domain 8  score: 13.2 bits;  conditional E-value: 3.5e-05
                 --EEE--SS---E-S-HH..H-TT--EEE-.-S CS
       LRR_4   3 LevLdLsnNqltdiplle..klpnLkeLdLsgN 33 
                 L++L+L+ N++t  +ll+  ++++ ++L L +N
  EFC38945.1 265 LTNLSLAKNNITNEGLLSisQMKQITKLFLQHN 297
                 9***********988877757*********887 PP

  == domain 9  score: 10.5 bits;  conditional E-value: 0.00025
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +nL+ L++s++++t+ +   + +l+n ++L++s N +++d
  EFC38945.1 311 TNLRLLNISQTKITTEGIkhITSLKNITSLNISIN-QLND 349
                 7*************877787779********9556.6644 PP

  == domain 10  score: 7.0 bits;  conditional E-value: 0.0031
                 EEE--SS---E-S-..HHH-TT--EEE-.-S.......- CS
       LRR_4   5 vLdLsnNqltdipl..leklpnLkeLdLsgN.......n 34 
                 +L+ +nN+lt+ +   +++l nL+eL++s+N       n
  EFC38945.1 363 NLSTHNNKLTSEGAkhISQLNNLTELNISSNpvriegaN 401
                 444458899988888766799999999988844444443 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0024       6.1      81     128 ..     111     158 ..      99     162 .. 0.82
   2 !   11.5   0.0   6.2e-05      0.16      62     143 ..     165     245 ..     159     249 .. 0.88
   3 ?    1.3   0.4     0.085   2.2e+02     104     128 ..     254     278 ..     240     296 .. 0.57
   4 ?    2.2   5.2     0.044   1.1e+02      49     125 ..     270     347 ..     260     355 .. 0.80
   5 ?    4.0   5.7     0.012        31      58     131 ..     329     402 ..     308     419 .. 0.72

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0024
       LRR_9  81 egleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 e ++++ Pnl+ l + +n+    +  + + ++k l++l +l++ +t+k
  EFC38945.1 111 EIISKSFPNLKRLEIGDNQQFGDCGAESISKIKTLTSLNVLDCGITSK 158
                 4568999******9999985555556*****************99987 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 6.2e-05
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlr 143
                 ll+ l  l + nn+i+  + ++   l +l+ l + + e+++ + ++ +  +k l++ls+ +npvt ++      i+ lk+l 
  EFC38945.1 165 LLNGLTYLNIGNNKIMDSGMKFIGKLSSLNVLQIGSTEITSES-FKLVGCMKGLTSLSIYSNPVTIEDAKSISSIHGLKSLN 245
                 7899999*******************************99854.5778889**************99988888888888876 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.085
       LRR_9 104 adldPlaslkklellsllknpvtnk 128
                   l+ l  l  l++lsl kn +tn+
  EFC38945.1 254 EGLKYLSALTLLTNLSLAKNNITNE 278
                 3445566666666666666666654 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.044
       LRR_9  49 lsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 l+ n+i +  l ++  +k++  l+l+ n i   + +l  ++ nl+ l +++ +++    ++ ++slk++++l +  n +
  EFC38945.1 270 LAKNNITNegLLSISQMKQITKLFLQHNVIDCDGAQLLSTMTNLRLLNISQTKITTE-GIKHITSLKNITSLNISINQL 347
                 5556665422556678999999********999999999999999999999999874.579999999999998877765 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.012
       LRR_9  58 dgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk.key 131
                   +  lk + +l ++ n++   a +l  ++ +l++l   nn+l++ +  + + +l++l+ l + +npv  +  +y
  EFC38945.1 329 KHITSLKNITSLNISINQLNDEALKLVSSMNQLTNLSTHNNKLTSEGA-KHISQLNNLTELNISSNPVRIEgANY 402
                 344456666677777777777777788888888999999999999887.89999************996441445 PP

>> Rtf2  Rtf2 RING-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.4   4.6e-05      0.12      66     103 ..     315     352 ..     285     365 .. 0.82
   2 !    4.9   0.1    0.0057        14      70      98 ..     367     395 ..     358     410 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.6e-05
        Rtf2  66 Lldkskekslskaashikglkdvvelkltknpafeesk 103
                 Ll+ s++k +++ ++hi++lk+++ l+++ n+  +e+ 
  EFC38945.1 315 LLNISQTKITTEGIKHITSLKNITSLNISINQLNDEAL 352
                 78888889999********************9877654 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0057
        Rtf2  70 skekslskaashikglkdvvelkltknpa 98 
                 +++k +s+ a+hi +l +++el++++np 
  EFC38945.1 367 HNNKLTSEGAKHISQLNNLTELNISSNPV 395
                 45577889999****************95 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.8   4.2e-06     0.011       5      37 ..      26      59 ..      24      63 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 4.2e-06
  F-box-like  5 PdEiLlqIFsyLp.psdLlrlalVCrrWrrvald 37
                Pd+i+ +I ++L   + Ll+++l +++W ++a +
  EFC38945.1 26 PDDICEEIMQWLAwKEVLLNCCLISKQWFTIAKS 59
                9***********62556**************954 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.1         7   1.8e+04       9      15 ..      45      51 ..      44      53 .. 0.70
   2 ?    2.7   0.0      0.11   2.9e+02       1      11 [.     119     129 ..     119     141 .. 0.79
   3 ?   -1.4   0.0       2.4   6.2e+03       2      16 ..     145     159 ..     144     164 .. 0.75
   4 ?    4.7   0.0     0.024        61       2      13 ..     169     187 ..     168     209 .. 0.73
   5 ?   -0.4   0.0       1.2   3.1e+03       2      13 ..     217     228 ..     216     239 .. 0.75
   6 ?    2.6   0.5      0.12   3.1e+02       2      14 ..     241     253 ..     240     285 .. 0.80
   7 ?    3.1   0.1     0.085   2.2e+02       1      20 [.     312     331 ..     312     334 .. 0.80
   8 ?   -0.8   0.5       1.5   3.9e+03       2      12 ..     337     347 ..     336     382 .. 0.58
   9 ?    6.5   0.1    0.0064        16       1      12 [.     384     395 ..     384     404 .. 0.85
  10 ?    2.6   0.1      0.12   3.1e+02       2      11 ..     409     418 ..     408     433 .. 0.79

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 7
       LRR_1  9 nnpllgl 15
                n++l+++
  EFC38945.1 45 NCCLISK 51
                6888655 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnp 11 
                 nL++L +++n+
  EFC38945.1 119 NLKRLEIGDNQ 129
                 8******9997 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 2.4
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L++L++ ++ +++++
  EFC38945.1 145 LTSLNVLDCGITSKG 159
                 899999888887665 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.024
       LRR_1   2 LrhLdLsnnpl.......l 13 
                 L++L+++nn +       +
  EFC38945.1 169 LTYLNIGNNKImdsgmkfI 187
                 89*******9855544442 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 1.2
       LRR_1   2 LrhLdLsnnpll 13 
                 L++L + +np +
  EFC38945.1 217 LTSLSIYSNPVT 228
                 899******964 PP

  == domain 6  score: 2.6 bits;  conditional E-value: 0.12
       LRR_1   2 LrhLdLsnnpllg 14 
                 L++L++sn  ++ 
  EFC38945.1 241 LKSLNISNTGISV 253
                 999**99987744 PP

  == domain 7  score: 3.1 bits;  conditional E-value: 0.085
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nLr L++s+  ++  ++ ++
  EFC38945.1 312 NLRLLNISQTKITTEGIKHI 331
                 8*******999877777666 PP

  == domain 8  score: -0.8 bits;  conditional E-value: 1.5
       LRR_1   2 LrhLdLsnnpl 12 
                  ++L++s n+l
  EFC38945.1 337 ITSLNISINQL 347
                 56777765554 PP

  == domain 9  score: 6.5 bits;  conditional E-value: 0.0064
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++L++s+np 
  EFC38945.1 384 NLTELNISSNPV 395
                 8*********95 PP

  == domain 10  score: 2.6 bits;  conditional E-value: 0.12
       LRR_1   2 LrhLdLsnnp 11 
                 L+ +++sn++
  EFC38945.1 409 LKIINVSNCR 418
                 99****9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       670  (0.0373696); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.69u 0.29s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 2616.69
//
Query:       EFC38946.1  [L=453]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      5e-15   55.6   0.2    1.4e-14   54.2   0.2    1.7  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.2   0.2   7.7e-19   1.4e-14       3     103 .]       4     110 ..       3     110 .. 0.89

  Alignments for each domain:
  == domain 1  score: 54.2 bits;  conditional E-value: 7.7e-19
                 EEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSSSSEE.......EEEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTT CS
          C2   3 levtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknslnPvW.......nekftfevaeleeakLeveVfdndrlskddfiGkveiplstllsg 94 
                 + ++  +AknL++kd +++sdp v +++++k+ +kT+ i   +nP W       +++ft++ ++  +++++++V d++ +sk++ iG ++ipl+ l+++
  EFC38946.1   4 INIRLRQAKNLAAKDLSKTSDPLVICTVNNKKSFKTEPIMMDCNPNWethkkpiKHEFTVNFDK-LTDVIQLQVEDYNIFSKNKPIGSCQIPLQFLEKS 101
                 678999*******************************776666****66666666667776666.********************************** PP

                 HHHHEEEEH CS
          C2  95 eeaegwypl 103
                 +++e +++l
  EFC38946.1 102 KPMEFTFDL 110
                 *99998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (453 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       851  (0.047465); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.48
# Mc/sec: 2843.53
//
Query:       EFC38947.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    4.9e-26   88.5   5.1    0.00079   19.3   0.1    8.2  8  LRR_6       Leucine Rich repeat
    2.6e-15   55.9   6.5    5.1e-07   29.3   0.6    4.2  4  LRR_8       Leucine rich repeat
    6.2e-15   55.1   7.4     0.0017   18.7   1.0    4.9  4  LRR_4       Leucine Rich repeats (2 copies)
    0.00021   21.4   4.5         23    6.1   0.1    6.3  7  LRR_1       Leucine Rich Repeat
    0.00064   19.5   0.1     0.0061   16.3   0.0    2.1  2  FTH         FTH domain
     0.0007   19.8   0.3       0.81   10.0   0.1    3.5  4  Phage_CI_C  Bacteriophage CI repressor C-terminal domain
     0.0014   18.2   1.0       0.47   10.2   0.0    3.2  4  RecO_N_2    RecO N terminal
  ------ inclusion threshold ------
       0.06   13.3   2.3         25    4.9   0.0    4.3  4  ApoB100_C   Apolipoprotein B100 C terminal


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0     0.005        11      12      24 .]      11      23 ..      11      23 .. 0.91
   2 !    6.2   0.0    0.0056        12       5      24 .]      28      47 ..      24      47 .. 0.89
   3 !   19.3   0.1   3.5e-07   0.00079       4      24 .]      51      71 ..      48      71 .. 0.91
   4 !    6.1   0.0    0.0059        13       5      24 .]      76      95 ..      73      95 .. 0.87
   5 !   14.7   0.0     1e-05     0.023       3      24 .]      98     119 ..      96     119 .. 0.91
   6 !   17.1   0.0   1.8e-06     0.004       5      23 ..     124     142 ..     121     143 .. 0.92
   7 ?    4.2   0.0     0.024        54       3      24 .]     146     167 ..     144     167 .. 0.90
   8 !    8.6   0.0   0.00093       2.1       5      19 ..     172     186 ..     169     191 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.005
       LRR_6 12 gNdIgDeGaeaLa 24
                +NdIg eGa+ ++
  EFC38947.1 11 FNDIGVEGAKHIS 23
                6*********986 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0056
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt L +sgN +g eGa+ ++
  EFC38947.1 28 LTFLGVSGNFVGVEGAKYIS 47
                999*************9875 PP

  == domain 3  score: 19.3 bits;  conditional E-value: 3.5e-07
       LRR_6  4 hLteLdLsgNdIgDeGaeaLa 24
                 Lt Ld+ +N+IgDeGa+ ++
  EFC38947.1 51 QLTNLDICFNNIGDEGAKHIS 71
                59****************986 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0059
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                L+ L +  N Ig eGa+ ++
  EFC38947.1 76 LKNLKIGNNYIGVEGAKYIS 95
                8889999999******9885 PP

  == domain 5  score: 14.7 bits;  conditional E-value: 1e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  h+t+L++s+N++  eG++ ++
  EFC38947.1  98 KHVTKLSISYNNVRVEGVKYIS 119
                 69****************9875 PP

  == domain 6  score: 17.1 bits;  conditional E-value: 1.8e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++  N IgDeGa+ +
  EFC38947.1 124 LTDLNIGENVIGDEGAKHI 142
                 9***************987 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.024
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt L++sg +I+ +Ga+ ++
  EFC38947.1 146 NQLTRLSISGVEISEAGAKYIC 167
                 579**************99987 PP

  == domain 8  score: 8.6 bits;  conditional E-value: 0.00093
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt L+++ N+Ig  G
  EFC38947.1 172 LTQLNIKNNNIGKIG 186
                 9**********9766 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.015        33      42      59 ..      19      36 ..       1      37 [. 0.79
   2 !   29.3   0.6   2.3e-10   5.1e-07       2      60 ..      51     109 ..      50     110 .. 0.98
   3 !   23.0   0.1   2.1e-08   4.8e-05       2      58 ..      99     155 ..      98     158 .. 0.97
   4 !   14.1   0.4   1.3e-05      0.03       2      41 ..     147     186 ..     146     197 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.015
                GGGGTT--S-.EEE--SS CS
       LRR_8 42 pgafsgLpsLrsLdLsgN 59
                ++ +s+L++L++L +sgN
  EFC38947.1 19 AKHISQLKQLTFLGVSGN 36
                567899*********999 PP

  == domain 2  score: 29.3 bits;  conditional E-value: 2.3e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+Ld+++N++ + + +  + l++Lk L+++nN + +  ++ +s+L+++++L +s+N+
  EFC38947.1  51 QLTNLDICFNNIGDEGAKHISELKQLKNLKIGNNYIGVEGAKYISQLKHVTKLSISYNN 109
                 7*********************************************************8 PP

  == domain 3  score: 23.0 bits;  conditional E-value: 2.1e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 ++t+L++s N+  + + +  + +++L+ L++++N +    ++ +  L++L+ L +sg
  EFC38947.1  99 HVTKLSISYNNVRVEGVKYISEMKQLTDLNIGENVIGDEGAKHIKKLNQLTRLSISG 155
                 799***************************************************997 PP

  == domain 4  score: 14.1 bits;  conditional E-value: 1.3e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGG CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttls 41 
                 +Lt+L++s   +++ + +    +++L+ L+++nN++  + 
  EFC38947.1 147 QLTRLSISGVEISEAGAKYICEMKQLTQLNIKNNNIGKIG 186
                 7999*******************************98885 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.0    0.0089        20       2      33 ..       3      36 ..       2      50 .. 0.80
   2 !   18.7   1.0   7.6e-07    0.0017       1      36 [.      50      86 ..      50      92 .. 0.89
   3 !   15.6   0.0   7.2e-06     0.016       2      34 ..      99     136 ..      98     162 .. 0.69
   4 !   15.6   0.4   7.5e-06     0.017       3      39 ..     148     185 ..     146     200 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0089
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33
                +L +L    N +   +   +++l++L+ L +sgN
  EFC38947.1  3 RLSHLRACFNDIGVEGAkhISQLKQLTFLGVSGN 36
                6888888888999655576667999999999999 PP

  == domain 2  score: 18.7 bits;  conditional E-value: 7.6e-07
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36
                ++L++Ld+  N++ d +   ++ l++Lk L + gNn+i
  EFC38947.1 50 KQLTNLDICFNNIGDEGAkhISELKQLKNLKI-GNNYI 86
                58*************99987555*********.99999 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 7.2e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S...- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN...n 34 
                 + ++L++s N+++  +   ++ +++L+ L++ +N    
  EFC38947.1  99 HVTKLSISYNNVRVEGVkyISEMKQLTDLNIGENvigD 136
                 6799****66666433443556*********7774440 PP

  == domain 4  score: 15.6 bits;  conditional E-value: 7.5e-06
                 --EEE--SS---E-S-...HHH-TT--EEE-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdipl...leklpnLkeLdLsgNnlitdl 39 
                 L+ L++s+  +++ +    +e +++L++L++  Nn+i+++
  EFC38947.1 148 LTRLSISGVEISEAGAkyiCE-MKQLTQLNI-KNNNIGKI 185
                 788888886777777765444.999999999.88889888 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       2.1   4.8e+03       2      21 ..       4      23 ..       3      25 .. 0.68
   2 ?   -1.2   0.0       2.4   5.4e+03       2      16 ..      28      42 ..      27      49 .. 0.68
   3 ?    6.1   0.1      0.01        23       2      23 .]      52      73 ..      51      73 .. 0.88
   4 ?    2.6   0.1      0.14   3.1e+02       2      20 ..      76      94 ..      75     119 .. 0.77
   5 ?    2.9   0.0      0.11   2.5e+02       2      23 .]     124     145 ..     123     145 .. 0.90
   6 ?   -2.2   0.0       5.2   1.2e+04       2       9 ..     148     155 ..     147     158 .. 0.83
   7 ?    4.5   0.1     0.033        75       2      19 ..     172     189 ..     171     197 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 2.1
       LRR_1  2 LrhLdLsnnpllglppnsfq 21
                L hL  + n ++  ++ +++
  EFC38947.1  4 LSHLRACFNDIGVEGAKHIS 23
                67888788888777766665 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 2.4
       LRR_1  2 LrhLdLsnnpllglp 16
                L+ L +s+n+ +  +
  EFC38947.1 28 LTFLGVSGNFVGVEG 42
                778889999975555 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.01
       LRR_1  2 LrhLdLsnnpllglppnsfqnL 23
                L+ Ld++ n++++ ++ +++ L
  EFC38947.1 52 LTNLDICFNNIGDEGAKHISEL 73
                899********99999998865 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.14
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                L+ L ++nn ++  ++ ++
  EFC38947.1 76 LKNLKIGNNYIGVEGAKYI 94
                8888899998865555554 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.11
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ L+++ n +++ ++ ++++L
  EFC38947.1 124 LTDLNIGENVIGDEGAKHIKKL 145
                 889***********99999987 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 5.2
       LRR_1   2 LrhLdLsn 9  
                 L++L +s+
  EFC38947.1 148 LTRLSISG 155
                 89999986 PP

  == domain 7  score: 4.5 bits;  conditional E-value: 0.033
       LRR_1   2 LrhLdLsnnpllglppns 19 
                 L+ L++ nn+++ +++++
  EFC38947.1 172 LTQLNIKNNNIGKIGKEY 189
                 899******997766665 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.7e-06    0.0061      42     112 ..      50     121 ..      21     129 .. 0.92
   2 ?    1.2   0.0      0.13     3e+02      83     112 ..     140     169 ..     121     194 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.7e-06
         FTH  42 gtLeeIel.sseeeeeefeelveleQWKnAkklkiessklssfpiehlfhFeefeikldkfsvedaikirdi 112
                 ++L ++++ +++   e  + + el+Q Kn k  + +     ++ i +l h ++++i+ +++ ve +++i ++
  EFC38947.1  50 KQLTNLDIcFNNIGDEGAKHISELKQLKNLKIGNNYIGVEGAKYISQLKHVTKLSISYNNVRVEGVKYISEM 121
                 67999999888889999*****************9999999999**********************999775 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.13
         FTH  83 fpiehlfhFeefeikldkfsvedaikirdi 112
                 ++i++l ++++++i+  ++s+  a++i ++
  EFC38947.1 140 KHIKKLNQLTRLSISGVEISEAGAKYICEM 169
                 378888888889998888888888888766 PP

>> Phage_CI_C  Bacteriophage CI repressor C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.4   3.1e+03      59      73 ..      14      28 ..      13      39 .. 0.86
   2 ?   -0.0   0.0      0.48   1.1e+03      59      74 ..      38      53 ..      33      65 .. 0.79
   3 ?    5.4   0.0      0.01        23      48      88 ..      75     113 ..      60     123 .. 0.79
   4 !   10.0   0.1   0.00036      0.81      47      96 ..     122     174 ..     110     178 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.4
  Phage_CI_C 59 vdieGrlsirelari 73
                +++eG++ i +l+++
  EFC38947.1 14 IGVEGAKHISQLKQL 28
                6799**999999876 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.48
  Phage_CI_C 59 vdieGrlsirelariP 74
                v++eG++ i +l+++ 
  EFC38947.1 38 VGVEGAKYISQLKQLT 53
                899*******999885 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.01
  Phage_CI_C  48 keadvsdGkwLvdieGrlsirelariPvkklrvsgdevsfe 88 
                 + ++++ G+  +++eG++ i +l+++   kl +s ++v +e
  EFC38947.1  75 QLKNLKIGNNYIGVEGAKYISQLKHVT--KLSISYNNVRVE 113
                 56788889999***********99976..888888777665 PP

  == domain 4  score: 10.0 bits;  conditional E-value: 0.00036
  Phage_CI_C  47 kkeadvsdGkwLvdieGrlsire...lariPvkklrvsgdevsfecklddikv 96 
                 k+ +d++ G+  ++ eG++ i++   l+r+ ++ +++s++++++ c++++++ 
  EFC38947.1 122 KQLTDLNIGENVIGDEGAKHIKKlnqLTRLSISGVEISEAGAKYICEMKQLTQ 174
                 456788889999999**99987522268999***************9998876 PP

>> RecO_N_2  RecO N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.0   0.00021      0.47      32      70 ..      16      59 ..      13      60 .. 0.91
   2 !    5.1   0.1    0.0083        19      44      70 ..      81     107 ..      65     108 .. 0.70
   3 ?   -1.9   0.0       1.3   2.8e+03      54      67 ..     139     152 ..     134     154 .. 0.73
   4 ?   -3.5   0.0       4.1   9.2e+03      54      67 ..     163     176 ..     159     178 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00021
    RecO_N_2 32 fyGarh.....sliqlgtkidfeleengkfLprLravlhlgfkw 70
                + Ga+h      l+ lg  ++f+  e +k++++L++ + l+  +
  EFC38947.1 16 VEGAKHisqlkQLTFLGVSGNFVGVEGAKYISQLKQLTNLDICF 59
                569999999999999***********************998765 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.0083
    RecO_N_2  44 tkidfeleengkfLprLravlhlgfkw 70 
                    ++   e +k++++L++v++l  ++
  EFC38947.1  81 IGNNYIGVEGAKYISQLKHVTKLSISY 107
                 44468888999************9887 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.3
    RecO_N_2  54 gkfLprLravlhlg 67 
                 +k +++L++ + l 
  EFC38947.1 139 AKHIKKLNQLTRLS 152
                 56788888888775 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 4.1
    RecO_N_2  54 gkfLprLravlhlg 67 
                 +k++  +++ ++l+
  EFC38947.1 163 AKYICEMKQLTQLN 176
                 56677777777776 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.37   8.4e+02      19      34 ..      68      83 ..      55     106 .. 0.73
   2 ?    4.9   0.0     0.011        25      19      32 ..     116     129 ..      96     132 .. 0.87
   3 ?    1.7   0.0      0.12   2.6e+02      13      34 ..     158     179 ..     147     182 .. 0.85
   4 ?    2.6   0.0     0.059   1.3e+02      18      32 ..     188     202 ..     186     203 .] 0.85

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.37
   ApoB100_C 19 kliaeskrLiDLsIek 34
                k i+e k+L  L I +
  EFC38947.1 68 KHISELKQLKNLKIGN 83
                6788888888888854 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.011
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k i+e k+L DL I
  EFC38947.1 116 KYISEMKQLTDLNI 129
                 89**********99 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.12
   ApoB100_C  13 lsdyyEkliaeskrLiDLsIek 34 
                 +s+   k i e k+L  L I++
  EFC38947.1 158 ISEAGAKYICEMKQLTQLNIKN 179
                 56666799**********9987 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.059
   ApoB100_C  18 EkliaeskrLiDLsI 32 
                 E + +e k LiDL +
  EFC38947.1 188 EYICTELKYLIDLEV 202
                 677899*******76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       595  (0.0331865); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 1345.75
//
Query:       EFC38948.1  [L=688]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-22   80.1   5.5    3.9e-10   40.0   0.0    4.1  4  Dynamin_N        Dynamin family
    1.9e-13   50.5   0.6    6.9e-13   48.7   0.0    2.4  3  MMR_HSR1         50S ribosome-binding GTPase
    1.1e-08   34.9   0.7    5.4e-08   32.6   0.2    2.5  1  GTP_EFTU         Elongation factor Tu GTP binding domain
    1.9e-06   27.9   0.5       0.05   13.5   0.1    3.1  2  RsgA_GTPase      RsgA GTPase
    0.00074   19.1   0.0       0.85    9.1   0.0    2.6  2  FeoB_N           Ferrous iron transport protein B
     0.0014   18.8   0.0     0.0072   16.5   0.0    2.3  1  Roc              Ras of Complex, Roc, domain of DAPkinase
     0.0018   18.0   0.0     0.0083   15.9   0.0    2.1  2  PduV-EutP        Ethanolamine utilisation - propanediol utili
     0.0034   16.6   0.3     0.0034   16.6   0.3    2.7  3  Phage_HK97_TLTM  Tail length tape measure protein
  ------ inclusion threshold ------
      0.025   15.1   0.4        1.4    9.5   0.1    3.3  2  YtxH             YtxH-like protein
      0.088   13.1   2.1       0.19   12.0   2.1    1.5  1  Retinin_C        Drosophila Retinin like protein
       0.29    9.8   1.6        3.9    6.0   0.0    2.2  2  Tweety           Tweety
        1.7    9.4  17.2        5.9    7.7   2.1    4.2  4  Occludin_ELL     Occludin homology domain


Domain annotation for each model (and alignments):
>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.6   0.0   3.7e-13   5.5e-10       2      47 ..     136     181 ..     135     195 .. 0.86
   2 !   40.0   0.0   2.6e-13   3.9e-10     100     165 ..     198     263 ..     183     266 .. 0.87
   3 ?   -2.8   0.2       3.8   5.7e+03      55      86 ..     395     429 ..     364     448 .. 0.52
   4 ?   -0.2   0.7       0.6     9e+02      49      80 ..     646     680 ..     606     687 .. 0.62

  Alignments for each domain:
  == domain 1  score: 39.6 bits;  conditional E-value: 3.7e-13
                 EEEEBTTTTHHHHHHHHHTS--S---SSS---S-EEEEECCT---C CS
   Dynamin_N   2 avvGsqSsGKSSvlnaLlgedilprgpnptTrrplelqlgeeeeas 47 
                 ++vG++++GKSS++na+lg+++l  g +ptT+ + ++++g +++ +
  EFC38948.1 136 VIVGEFNAGKSSFINAMLGDRYLREGITPTTAHLHVIRHGGDSNQK 181
                 79*************************************9998844 PP

  == domain 2  score: 40.0 bits;  conditional E-value: 2.6e-13
                 S-SEEEEE---B-SSSGTTSHHHHHHHSTTEEEEEEEETTS-CCC-CHHHHHHHHSTTBTTEEEEE CS
   Dynamin_N 100 vkgltlvDlPGldsvnkrdqelvkeyikkadiilavtsanhdlsnsealflarevdpkgkrtivvl 165
                  kg+++vD+PG + + k++q ++++++ +ad+i+++tsa+  +s+se +fl+   +  +k +++++
  EFC38948.1 198 LKGISVVDTPGTNAIIKEHQTITETFVPRADLIIFLTSAERPFSESEHTFLEMIRKWGKKVVVCIN 263
                 5899***********************************************987777777777776 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 3.8
                 EEEE...T-EB--CHHHHHHHHHHHHHHHTSSSS- CS
   Dynamin_N  55 lkek...ekkledfsevreeieketekiagankgi 86 
                  + +   ++  +df+  + ++e+ + ++++++ g+
  EFC38948.1 395 EQLQvfyNDMKQDFELQQAKLENIFHELSERGTGF 429
                 22223344444455555555555555555544444 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.6
                 S...SSEEEE...T-EB--CHHHHHHHHHHHHHHH CS
   Dynamin_N  49 ravkeelkek...ekkledfsevreeieketekia 80 
                 r+vk+e +++   +++l ++++v ++i+ke e ++
  EFC38948.1 646 RFVKAEHEKFstqKERLIELQKVINQIRKEIESLQ 680
                 34444444443335555555555555555554444 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.7   0.0   4.6e-16   6.9e-13       2     114 .]     135     264 ..     134     264 .. 0.83
   2 ?   -3.7   0.0       8.3   1.2e+04      24      41 ..     380     397 ..     364     421 .. 0.60
   3 ?   -3.3   0.0       6.3   9.4e+03      41      79 ..     462     472 ..     435     496 .. 0.51

  Alignments for each domain:
  == domain 1  score: 48.7 bits;  conditional E-value: 4.6e-16
                 EEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEE....................EEEEECGG...CSSHHHHHHHHHHHHHHHHCTS CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgke....................ielvDtpG...liegaseekglgkaflaleead 77 
                 ++ivG  N+GKS++ina++g++   + +  tT +   +r   + ++                    i +vDtpG   +i+   e++ ++++f    +ad
  EFC38948.1 135 MVIVGEFNAGKSSFINAMLGDRYLREGITPTTAHLHVIRHGGDSNQkfdernqlvnmelplkwlkgISVVDTPGtnaIIK---EHQTITETFV--PRAD 228
                 58***********************9********99998772222367777889999999999999********222233...4446667666..599* PP

                 EEEEEEETTTTCSHHHHHHHHHHHHHTTSEEEEEEES CS
    MMR_HSR1  78 lillvvdaseeklkpldeeleelleeakkplilvlnk 114
                 li+++ +a+ + +++ ++++ e++++ +k++++++nk
  EFC38948.1 229 LIIFLTSAE-RPFSESEHTFLEMIRKWGKKVVVCINK 264
                 ******976.77999999999999999********98 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 8.3
                 EEESSSTTSSSSEEEEEE CS
    MMR_HSR1  24 aivsdkpgtTrdinegrv 41 
                  +v ++  +T +i+e+++
  EFC38948.1 380 LKVLKEDKKTMEIIEEQL 397
                 344444444444444443 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 6.3
                 EEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEE CS
    MMR_HSR1  41 vklkgkeielvDtpGliegaseekglgkaflaleeadli 79 
                  +++++                             +++i
  EFC38948.1 462 TQIENHV----------------------------SEVI 472
                 2222212............................2333 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.6   0.2   3.6e-11   5.4e-08       2     181 ..     131     306 ..     130     447 .. 0.75

  Alignments for each domain:
  == domain 1  score: 32.6 bits;  conditional E-value: 3.6e-11
                 CEEEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH...HHHST......HCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHHHHHH. CS
    GTP_EFTU   2 rirnigiighvDhGKtTLtdrLlyktgaiskkgeka...eeerv......lDtlkeErergiTiksaaisleketkkylinliDtPGHvdFskevirg. 90 
                 ++  ++i+g  ++GK++++ ++l +    +  + ++       v        +  +Er++ + ++            + i+++DtPG    +ke  +  
  EFC38948.1 131 EHFLMVIVGEFNAGKSSFINAMLGDRYLREGITPTTahlH---VirhggdSNQKFDERNQLVNMELPLKW------LKGISVVDTPGTNAIIKEHQTIt 220
                 68889*****************966655444433331222...134443344444455554444444444......459***********999977763 PP

                 ...HHT-SEEEEEEETTTBSTHHHHHHHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBTTTTBTH CS
    GTP_EFTU  91 ...lrvlDgavlvvdaveGvepqteevlrlalkegvpiivfiNKmDrlkaelkeiveevkqklsrkeeklekygekgekevpvvfgSalkgegv 181
                    +  +D+ +++ +a++   +   + l++++k g +++v+iNK D l++e ++   ev   +  +++ ++  g++ +    ++++Sa ++  +
  EFC38948.1 221 etfVPRADLIIFLTSAERPFSESEHTFLEMIRKWGKKVVVCINKYDLLQNEKEQDEVEVF--V--RDGIIRLLGFEPK----IFCVSARSAMDF 306
                 3345679*****************************************766554443333..1..2344666677764....555555555444 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.1   3.4e-05      0.05      83     162 ..     115     210 ..      52     215 .. 0.58
   2 !   11.2   0.0   0.00017      0.25      13      70 ..     224     279 ..     212     311 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.4e-05
                  -TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT..............-----S--------------SEEEEEETT......TEEEESS- CS
  RsgA_GTPase  83 saktkegleelkellkd.ktsvlvGqSGvGKStLinallpe..............lelktgevseklgrGkhTTtavellelae......gglliDtP 159
                  s+++ + l++  ++l++  ++v+vG+  +GKS++ina+l++              +      +++  ++ +    + +l++++       g  ++DtP
   EFC38948.1 115 SEEDIDLLRKSINQLEEhFLMVIVGEFNAGKSSFINAMLGDrylregitpttahlH-----VIRHGGDSNQKFDERNQLVNMELplkwlkGISVVDTP 207
                  3333333333334455546899******************9666666666333332.....3333222222223333333322233333377777777 PP

                  SSS CS
  RsgA_GTPase 160 Gfr 162
                  G +
   EFC38948.1 208 GTN 210
                  766 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00017
                  EES--EEEEEEESTTTT--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHHHHHHHHH CS
  RsgA_GTPase  13 vaNvdqllivvslkepelslnlldrfLvlaeekgiepvivlnKiDlleeeeeleelke 70 
                  v   d ++ ++s++   +s++  + fL ++ + g ++v+++nK Dll++e+e +e++ 
   EFC38948.1 224 VPRADLIIFLTSAE-RPFSESE-HTFLEMIRKWGKKVVVCINKYDLLQNEKEQDEVEV 279
                  66677788888888.4454443.56999999*****************9996555544 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0    0.0026       3.8       3      23 ..     135     155 ..     133     159 .. 0.89
   2 !    9.1   0.0   0.00057      0.85      48     123 ..     200     273 ..     190     287 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0026
                 EEEEESTTSSHHHHHHHHHTT CS
      FeoB_N   3 valvGnpnvGkttlfnaltga 23 
                 +++vG+ n+Gk++++na+ g 
  EFC38948.1 135 MVIVGEFNAGKSSFINAMLGD 155
                 689**************9886 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00057
                 EEEEEE----SSSSSSSHHHHHHHHHHHCTSSSEEEEEEEGGG..HHHHHHHHHHHHHTTSSEEEEEETHHHHHHTTE CS
      FeoB_N  48 eveivDlPGiYslsayseeekvardflleeepdvvvnvvdatn..lernLyLtlqllelgvpvvlalnmideaekkgi 123
                  +++vD PG+ ++    e ++++++f+   ++d+++ +  a++   e + +++  +   g++vv+++n++d +++++ 
  EFC38948.1 200 GISVVDTPGTNAII--KEHQTITETFVP--RADLIIFLTSAERpfSESEHTFLEMIRKWGKKVVVCINKYDLLQNEKE 273
                 5899******9885..567788888886..6788888888876225777788888999*************9998765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   4.8e-06    0.0072       2     119 ..     135     266 ..     134     267 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 4.8e-06
                 EEEESSTTSSHHHHHHCHCT-CCC-E..EETTTTEEEEEEECGGSGGCTTBTTTTCEEE........EEEEE-SGG....CTTTT-HHHHCTSCEEEEE CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfsek..ekstigvdfltkevtkikgvendkkvkkvkl........niWDtaGqe....rfrslhplylreaalailv 86 
                 +v+vG+ ++GK+s+++ ++ d++ ++  + +t  + ++++   + +++++++++ +++l        ++ Dt G +    + +++++ ++ +a+l+i++
  EFC38948.1 135 MVIVGEFNAGKSSFINAMLGDRYLREgiTPTTAHLHVIRHGGDSNQKFDERNQLVNMELplkwlkgiSVVDTPGTNaiikEHQTITETFVPRADLIIFL 233
                 699******************9966533567778888887777777777777776666555555555889****8622215678999**********99 PP

                 EE.GHHH.HCHHHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  87 yd.srss.enlkeWlkelkkvagkspvilvgnkiD 119
                 +  +r + e+ ++ l+ ++k ++  +v++++nk+D
  EFC38948.1 234 TSaERPFsESEHTFLEMIRKWGK--KVVVCINKYD 266
                 98444452667899999999886..5788899998 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       3.4     5e+03       5      21 ..     136     152 ..     134     157 .. 0.81
   2 !   15.9   0.0   5.5e-06    0.0083      40     132 ..     203     304 ..     196     312 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 3.4
   PduV-EutP   5 lliGkvgsGKttLtqal 21 
                 +++G+ ++GK +  +a+
  EFC38948.1 136 VIVGEFNAGKSSFINAM 152
                 679*******9998876 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 5.5e-06
   PduV-EutP  40 viDtPGeylenrklysalivtsaeadvialvqdateeesvfppgfasvfn...keviGiitkidlaedeenieaveel.....LksaGae.kifevsav 129
                 v+DtPG  +  ++  +   ++   ad+i ++++a+++ s    +f ++++   k+v+  i k dl ++e++ + ve +     ++  G e kif+vsa 
  EFC38948.1 203 VVDTPGTNAIIKEHQTITETFVPRADLIIFLTSAERPFSESEHTFLEMIRkwgKKVVVCINKYDLLQNEKEQDEVEVFvrdgiIRLLGFEpKIFCVSAR 301
                 79************99999*********************99***9999733369**********9887776666544111115667765578888877 PP

   PduV-EutP 130 eke 132
                 +  
  EFC38948.1 302 SAM 304
                 665 PP

>> Phage_HK97_TLTM  Tail length tape measure protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0         2     3e+03      88     108 ..     110     130 ..      96     143 .. 0.74
   2 ?   -0.6   1.7       0.4     6e+02     101     179 ..     329     406 ..     304     426 .. 0.70
   3 !   16.6   0.3   2.3e-06    0.0034      22     126 ..     578     684 ..     560     687 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2
  Phage_HK97_TLTM  88 klvkeaeqkveelkkeldkyq 108
                       +v+  e++++ l+k +++ +
       EFC38948.1 110 ENVEGSEEDIDLLRKSINQLE 130
                      456778888999998888754 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.4
  Phage_HK97_TLTM 101 kkeldkyqvsingylvnkldskeeaiklaeatdklsesqsaleavtkkskeiqsaLtsveadrvrlirqq.aaeqnkvkr 179
                      k +l+++ + ++ y+ + l+s e+a kl   +  +  ++  ++ +t + +e  ++L++ +++  ++i++q  +  n++k+
       EFC38948.1 329 KTKLAENWLDLEKYVLDTLNSIERA-KLKFLSPLGVAQNLSEKYLTTNIEERLKVLKE-DKKTMEIIEEQlQVFYNDMKQ 406
                      3457777788888999999998887.77777777777777888888888888888888.444555555541455555555 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 2.3e-06
  Phage_HK97_TLTM  22 vG.GlpGlvilaAGafYll.YqkqkqAresAreyAkeieevkeklkklsleevadekdklkeslkeqnklvkeaeqkveelkkeldkyqvsing 113
                       G G+ G ++++AG  Y+l Y++    ++  re  k  e +k+++++    e+   +d +k+s+   ++ vk  ++k    k+ l + q  in 
       EFC38948.1 578 AGaGVVGALMVGAGGLYALpYKRATMRKNFIREVNKLKEVLKQRMREEFERELLSSIDSIKNSITPYSRFVKAEHEKFSTQKERLIELQKVINQ 671
                      33399*************96777777777788888888888999999999999******************************99999999998 PP

  Phage_HK97_TLTM 114 ylvnkldskeeai 126
                        ++    +e +i
       EFC38948.1 672 IRKEIESLQEADI 684
                      7766655555555 PP

>> YtxH  YtxH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.23   3.4e+02      32      53 ..     388     425 ..     370     473 .. 0.59
   2 ?    9.5   0.1   0.00092       1.4       4      53 ..     581     649 ..     578     682 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.23
        YtxH  32 ekaddlkekakelleeakeka................k 53 
                 ++++ + e+++ +++++k+                  +
  EFC38948.1 388 KTMEIIEEQLQVFYNDMKQDFelqqaklenifhelseR 425
                 45556666777777777666655533333333333330 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00092
        YtxH   4 lliGaavGaaaglLlAPksGketRkdlkekaddlkekakelleeakeka......................k 53 
                  ++Ga+   a gl   P +   +Rk   +++++lke +k   ++++e                        k
  EFC38948.1 581 GVVGALMVGAGGLYALPYKRATMRKNFIREVNKLKEVLK---QRMREEFerellssidsiknsitpysrfvK 649
                 58999999999************************9995...556666666675555555444444444440 PP

>> Retinin_C  Drosophila Retinin like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   2.1   0.00013      0.19      15      55 ..      42      83 ..      38      86 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00013
   Retinin_C 15 ksvPtavSHqSltqvHssa.vvepvvapvvkttvvaaPvvkt 55
                ++v + +S  S +q H+ + v+e+vva   +tt+ + P+++ 
  EFC38948.1 42 QQVASTTSSSSYAQQHQAPpVIEQVVAEESTTTTTSEPIIEE 83
                5678899********************99999999****975 PP

>> Tweety  Tweety
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.7      0.04        60      96     157 ..     381     450 ..     372     483 .. 0.67
   2 ?    6.0   0.0    0.0026       3.9     273     334 ..     618     679 ..     559     682 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.04
      Tweety  96 yslrkanhtlagikklvseteesleekleeeLtkleeifakrtd........lletlrlvqeqveevvqq 157
                 + l++  +t+  i+++ +   ++++++ e + +kle+if++  +        +++ +++     +++v++
  EFC38948.1 381 KVLKEDKKTMEIIEEQLQVFYNDMKQDFELQQAKLENIFHELSErgtgfydnFVNLSNISSLIKSKIVAE 450
                 56777889999********************9*******9988766676555333333333333333333 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0026
      Tweety 273 CsqsltnpFqqrLtesqkaltemqeqveellriavelfptaekkLlaiqellnsternlhqL 334
                  +q++++ F+++L +s +++++     + + +   e+f+t +++L ++q+++n+   +++ L
  EFC38948.1 618 LKQRMREEFERELLSSIDSIKNSITPYSRFVKAEHEKFSTQKERLIELQKVINQIRKEIESL 679
                 4677788999999999999999999999999999*******************988777665 PP

>> Occludin_ELL  Occludin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       4.7     7e+03      43      76 ..     321     358 ..     309     371 .. 0.68
   2 ?    7.7   2.1    0.0039       5.9      39      79 ..     374     414 ..     364     425 .. 0.87
   3 ?    3.5   0.0     0.081   1.2e+02      46      89 ..     459     503 ..     428     505 .. 0.69
   4 ?    3.1   4.7       0.1   1.5e+02      37      98 ..     614     678 ..     598     681 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 4.7
  Occludin_ELL  43 relkelkegsk...eykkieeeilqeykklkk.dpeyq 76 
                   rel e ++++k   ++ ++e+ +l++++++++ + +++
    EFC38948.1 321 RELAEKQKKTKlaeNWLDLEKYVLDTLNSIERaKLKFL 358
                   45555555555566788888888888888887666665 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0039
  Occludin_ELL  39 seLerelkelkegskeykkieeeilqeykklkkdpeyqekk 79 
                   +++e++lk lke++k+++ iee+++  y+++k+d e q++k
    EFC38948.1 374 TNIEERLKVLKEDKKTMEIIEEQLQVFYNDMKQDFELQQAK 414
                   57899**************************9999999887 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.081
  Occludin_ELL  46 kelkegskeykkieeeil.qeykklkkdpeyqekkkrceyLkekL 89 
                   +++++ +++++++++ i+ ++y+++k  +++ +k++r+   ++kL
    EFC38948.1 459 NTATQIENHVSEVIDWIIdRKYRQWKAVTDFANKRARISLHEDKL 503
                   344444557777777766258****************98777776 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.1
  Occludin_ELL  37 kfseLerelkelkegsk..eykkieeeilqeykklkk..dpeyqekkkrceyLkekLshiKklike 98 
                     + L+++++e  e++    +++i+++ +  y+++ k  ++++ ++k+r+ +L++  + i+k i++
    EFC38948.1 614 LKEVLKQRMREEFERELlsSIDSIKNS-ITPYSRFVKaeHEKFSTQKERLIELQKVINQIRKEIES 678
                   222333444444444336677777777.45566655546899*******************99975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (688 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1636  (0.0912488); expected 358.6 (0.02)
Passed bias filter:                      533  (0.0297284); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.79u 0.32s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 3971.72
//
Query:       EFC38949.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0035   17.3   0.3      0.012   15.6   0.1    1.7  2  zf-TFIIIC  Putative zinc-finger of transcription factor IIIC 
     0.0086   15.8   3.7      0.015   15.1   3.7    1.4  1  AT_hook    AT hook motif


Domain annotation for each model (and alignments):
>> zf-TFIIIC  Putative zinc-finger of transcription factor IIIC complex
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0       0.1   9.3e+02      48      73 ..      29      54 ..      13      69 .. 0.56
   2 !   15.6   0.1   1.3e-06     0.012      11      57 ..      68     114 ..      53     121 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.1
   zf-TFIIIC 48 qepkiskvCilcstevldeelveaqe 73
                ++ ++ k+ + ++ +vl+e++  +++
  EFC38949.1 29 EQIQVDKTISASNPQVLEENQKVSTQ 54
                33344556666666666665544444 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 1.3e-06
   zf-TFIIIC  11 kesCdicdagipleslteaqckeGHvfsRCaltflaiqepkiskvCi 57 
                 +  Cd+++++ pl s ++  +   H+ +R  l f++++++ is  C 
  EFC38949.1  68 NVICDTISQSEPLPSNRNESSSTDHTNNRTELNFVIVSASTISEKCY 114
                 4579999**************************************96 PP

>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   3.7   1.7e-06     0.015       1      10 [.     118     127 ..     118     129 .. 0.93

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.7e-06
     AT_hook   1 kRkRGRPrKa 10 
                 kR+RGRPrK+
  EFC38949.1 118 KRGRGRPRKN 127
                 8********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1113  (0.0620782); expected 358.6 (0.02)
Passed bias filter:                      308  (0.0171789); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 868.58
//
Query:       EFC38950.1  [L=713]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-73  246.4   8.5    2.6e-70  237.5   0.1    3.1  4  p450      Cytochrome P450
    2.7e-05   23.9   0.2     0.0013   18.7   0.2    3.0  2  TPR_2     Tetratricopeptide repeat
    0.00048   20.7   0.1     0.0032   18.1   0.0    2.5  3  Sel1      Sel1 repeat
    0.00058   20.3   0.4        8.5    7.2   0.1    4.2  3  TPR_6     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.019   15.5   2.2         13    6.4   0.0    3.7  4  TipAS     TipAS antibiotic-recognition domain
      0.028   14.4   0.0       0.24   11.5   0.0    2.6  2  TPR_7     Tetratricopeptide repeat
      0.038   13.8   0.2       0.97    9.4   0.3    2.8  2  TPR_1     Tetratricopeptide repeat
      0.071   13.4   0.8       0.32   11.3   0.2    2.5  2  TPR_8     Tetratricopeptide repeat
        0.2   10.7   0.5       0.52    9.3   0.5    1.6  1  MCR_C     Methyl-coenzyme M reductase operon protein C
       0.39   10.8   5.4       0.19   11.8   0.2    2.9  3  DUF4363   Domain of unknown function (DUF4363)


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       0.5     9e+02     199     234 ..      41      76 ..      11     134 .. 0.56
   2 ?   -2.6   0.2      0.96   1.7e+03     188     227 ..     182     222 ..     157     231 .. 0.63
   3 !   14.1   0.0   8.4e-06     0.015      36     142 ..     338     444 ..     306     460 .. 0.70
   4 !  237.5   0.1   1.4e-73   2.6e-70     210     461 ..     457     706 ..     440     708 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.5
                 TCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHC CS
        p450 199 kylptkllrklkeavkklkdlldklieerretldsa 234
                 ++++++  r ++e ++ ++++ +++ e+++++ +++
  EFC38950.1  41 FPIFNQNDRNANETQNLIDEISKAIREQQYSKAKQT 76 
                 444444444444443333333333333333333322 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.96
                 HHHCCCCCH.HHTCCSCHHHHHHHHHHHHHHHHHHHHHHHH CS
        p450 188 svqllllfp.llkylptkllrklkeavkklkdlldklieer 227
                  +q++  f  +++  +   ++k+++a++++ + ++k++++ 
  EFC38950.1 182 IQQFDSRFAhFALGKFYMKNQKYQKACEAFTQSTEKKFTKS 222
                 33344444444444555567888888999999988888765 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 8.4e-06
                 EEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHHTSHSTTTHHHHHHHHHHHHHHH..HHCC CS
        p450  36 ifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltptltsfgklsleelveeeaedlvek..lrkk 132
                 ++r+  ++ + +++s+ e+ k +  +k     + p+++++   ++ f g  v   + + wkk+++++ p++ s+ +l++++ v +e+ d +++  ++++
  EFC38950.1 338 TLRITTMNLNRIFVSDREMLKDIHSRKL---GFFPKSKTFLEPTEVFGGHIVSAPDTDSWKKHHNTISPAFSSN-NLEYMSHVSSETVDTMAQclWNPD 432
                 5677788888899*************96...55555666666668888888888888*****************.886666666665554443223333 PP

                 CCHCS..EEETH CS
        p450 133 agess..eldit 142
                  ++++  ++d +
  EFC38950.1 433 IESKGehVIDRV 444
                 333334455544 PP

  == domain 4  score: 237.5 bits;  conditional E-value: 1.4e-73
                 HHHHHHHHHHHHHHHHHHHHCHCHC.SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHC CS
        p450 210 keavkklkdlldklieerretldsa.kksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEidevl 307
                  +  +++ + +++li +++e+++++ + s+rd +++++++    +++ +l++ee+  +++ +++aG+dT+s+tl+w+Lye+aknP++q++l+eE+d++l
  EFC38950.1 457 AKYIDRFVERVQNLIDQKKEEIERDgEVSTRDVVSLMIQEN--LNNK-ELTKEEILSNAFIFFIAGMDTSSNTLQWFLYEIAKNPSLQKRLQEEVDNIL 552
                 333345555555666666666666676789********996..8888.9************************************************** PP

                 CTTTT-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTS.CTESSCTT--TT CS
        p450 308 gdkreptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRFldekg.nskrksfaflPF 405
                 ++kr+pt+dd ++l + +a+i+EtLR hp+v  ++ + + k+v+++ ++ipkG+++  +l+a +++p+v+pn+  F+p+RF d ++  ++ +++  l F
  EFC38950.1 553 PNKRKPTFDDYNQLNLITACIHETLRVHPPVT-SVAKDCAKPVQLGPFHIPKGSVIYSFLTAANKNPKVWPNALAFNPDRFYDPDVkSKSANDYTLLSF 650
                 999*****************************.***************************************************99755589999**** PP

                 EEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSCSSEEESSSSEE CS
        p450 406 GaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileksglllppkpikl 461
                 ++G R C+G+++A  e+  +la++Lq++e+el +++++ p ++ s+l+++p+++ +
  EFC38950.1 651 SMGLRKCLGMKFALIEMTCVLARMLQYYEFELLNDESVDPVMNFSKLTVKPSNLRI 706
                 ********************************************999999998766 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.2   7.3e-07    0.0013       3      29 ..     190     216 ..     188     218 .. 0.92
   2 ?    1.6   0.0      0.21   3.8e+02      14      26 ..     240     252 ..     238     254 .. 0.85

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 7.3e-07
       TPR_2   3 alynlGlayyklgdyeeAleafekAle 29 
                 a+++lG+ y+k+++y++A eaf ++ e
  EFC38950.1 190 AHFALGKFYMKNQKYQKACEAFTQSTE 216
                 8*********************99765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.21
       TPR_2  14 lgdyeeAleafek 26 
                 ++++e+Ale+f+k
  EFC38950.1 240 SKNPERALELFKK 252
                 6899*******98 PP

>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       6.9   1.2e+04       3      12 ..     190     199 ..     189     200 .. 0.78
   2 !   18.1   0.0   1.8e-06    0.0032       2      32 ..     221     252 ..     220     253 .. 0.89
   3 ?   -4.0   0.0        10   1.8e+04      11      17 ..     265     271 ..     264     280 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 6.9
        Sel1   3 AmyrLGmfyl 12 
                 A ++LG fy+
  EFC38950.1 190 AHFALGKFYM 199
                 899***7774 PP

  == domain 2  score: 18.1 bits;  conditional E-value: 1.8e-06
        Sel1   2 eAmyrLGmfylylnGl..g.vpkDpekAiewyek 32 
                  +++ LG  +l  nG   g v k+pe+A+e+++k
  EFC38950.1 221 KSQFELG--LLMRNGSpdGmVSKNPERALELFKK 252
                 58*****..5559****978*************9 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 10
        Sel1  11 ylylnGl 17 
                 ++ylnG 
  EFC38950.1 265 EMYLNGE 271
                 5889996 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.1     0.065   1.2e+02      11      29 ..      66      83 ..      60      84 .. 0.84
   2 !    7.2   0.1    0.0048       8.5       2      25 ..     190     213 ..     189     217 .. 0.87
   3 ?    4.3   0.0     0.042        75       2      25 ..     222     252 ..     221     255 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.065
                HHHHHHHHHHHHHHHHHHH CS
       TPR_6 11 rklgdtdkAlealerlike 29
                r++ +++kA+++l+ l k+
  EFC38950.1 66 REQ-QYSKAKQTLRGLTKN 83
                557.**********99887 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0048
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealer 25 
                 A + l++ y k ++++kA+ea+ +
  EFC38950.1 190 AHFALGKFYMKNQKYQKACEAFTQ 213
                 78999******55*********87 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.042
                 HHHHHHHHHHHH.......HHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl.......gdtdkAlealer 25 
                 +++ l+l++r++       +++++Ale++++
  EFC38950.1 222 SQFELGLLMRNGspdgmvsKNPERALELFKK 252
                 5799*******99***************986 PP

>> TipAS  TipAS antibiotic-recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0073        13      52      97 ..      47      92 ..      37     100 .. 0.88
   2 ?    4.6   0.2     0.026        46      59     107 ..     170     217 ..     144     225 .. 0.71
   3 ?    1.1   0.0      0.31   5.6e+02      77      94 ..     255     272 ..     241     292 .. 0.82
   4 ?   -2.4   0.0       3.8   6.8e+03      19      71 ..     464     479 ..     438     507 .. 0.56

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0073
                XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
       TipAS 52 kdpdseeaqelaeehralieefwgecskeilaglgqmYvadprfte 97
                 d + +e q+l++e+ + i+e  ++  k+ l+gl++ ++   +f +
  EFC38950.1 47 NDRNANETQNLIDEISKAIREQQYSKAKQTLRGLTKNWLGFYKFDD 92
                5677899*************99999************998888766 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.026
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXX CS
       TipAS  59 aqelaeehralieefwgecskeilaglgqmYvadprftenydkkg.egla 107
                 +q  +e h + + + ++  s+ ++  lg++Y+ ++++++  +++  +   
  EFC38950.1 170 VQLTIESHLKELIQQFD--SRFAHFALGKFYMKNQKYQKACEAFTqSTEK 217
                 55566666655555577..8999*************99988888644444 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.31
                 XXXXXXXXXXXXXXXXXX CS
       TipAS  77 cskeilaglgqmYvadpr 94 
                  ++++++ l++mY+  + 
  EFC38950.1 255 WEPQAHKELVEMYLNGEA 272
                 6799*********98775 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 3.8
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXX CS
       TipAS  19 eekiaklskedweelkaelkelfaklaaalaagkdpdseeaqelaeehralie 71 
                                                       e++q+l+++ ++ ie
  EFC38950.1 464 V-------------------------------------ERVQNLIDQKKEEIE 479
                 2.....................................333333333333333 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00014      0.24       1      28 [.     190     215 ..     190     224 .. 0.88
   2 ?   -1.6   0.0         2   3.6e+03      15      24 ..     243     252 ..     242     262 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00014
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLal 28 
                 a+++L+  y + ++y++A e ++q   +
  EFC38950.1 190 AHFALGKFYMKNQKYQKACEAFTQ--ST 215
                 6799********************..55 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 2
       TPR_7  15 yeeAielyeq 24 
                  e+A+el+++
  EFC38950.1 243 PERALELFKK 252
                 589*****98 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.3   0.00054      0.97       3      26 ..     190     213 ..     189     217 .. 0.89
   2 ?    0.8   0.0      0.28     5e+02      15      26 ..     241     252 ..     238     253 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00054
                 HHHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyek 26 
                 a++ lG  y+k++ky++A e++ +
  EFC38950.1 190 AHFALGKFYMKNQKYQKACEAFTQ 213
                 8999**************999887 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.28
                 T-HHHHHHHHHH CS
       TPR_1  15 gkydeAleyyek 26 
                 ++++ Ale ++k
  EFC38950.1 241 KNPERALELFKK 252
                 79999***9998 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       9.8   1.8e+04      15      25 ..      68      78 ..      65      79 .. 0.80
   2 ?   11.3   0.2   0.00018      0.32       3      28 ..     190     215 ..     190     216 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 9.8
                T-HHHHHHHHH CS
       TPR_8 15 gdyeeAkeyye 25
                ++y +Ak++++
  EFC38950.1 68 QQYSKAKQTLR 78
                78999999876 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00018
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekal 28 
                 a++ lg+ y+k ++y++A e++ + +
  EFC38950.1 190 AHFALGKFYMKNQKYQKACEAFTQST 215
                 5799******************9976 PP

>> MCR_C  Methyl-coenzyme M reductase operon protein C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.5   0.00029      0.52     196     239 ..     458     501 ..     440     512 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00029
       MCR_C 196 ealdelveeveevldkkreelakDpllvsparvkkeieeqveei 239
                 + +d+ ve+v++++d+k+ee+++D  + +  +v  +i+e++++ 
  EFC38950.1 458 KYIDRFVERVQNLIDQKKEEIERDGEVSTRDVVSLMIQENLNNK 501
                 56899********************9999999999999998765 PP

>> DUF4363  Domain of unknown function (DUF4363)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   0.00011      0.19       8      44 ..      48      84 ..      43      90 .. 0.90
   2 ?   -3.4   0.1       5.9   1.1e+04      39      55 ..     196     212 ..     175     218 .. 0.50
   3 ?   -0.1   0.1      0.56     1e+03       4      28 ..     457     481 ..     455     502 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00011
     DUF4363  8 kkstdelsekleeleeaienedweeakekleelekeW 44
                ++ ++e+++ ++e+ +ai ++++++ak++l+ l k+W
  EFC38950.1 48 DRNANETQNLIDEISKAIREQQYSKAKQTLRGLTKNW 84
                577899******************************* PP

  == domain 2  score: -3.4 bits;  conditional E-value: 5.9
     DUF4363  39 elekeWekkkkklsifi 55 
                 +++ + +k++k ++ f+
  EFC38950.1 196 KFYMKNQKYQKACEAFT 212
                 44444444444444443 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.56
     DUF4363   4 qnylkkstdelsekleeleeaiene 28 
                 ++y+++ +++ ++ +++ +e+ie +
  EFC38950.1 457 AKYIDRFVERVQNLIDQKKEEIERD 481
                 6899999999999999999999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (713 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       976  (0.0544369); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.77u 0.32s 00:00:01.09 Elapsed: 00:00:00.51
# Mc/sec: 4238.57
//
Query:       EFC38951.1  [L=479]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.061   13.4   0.4       0.33   11.0   0.1    2.3  2  SRP1_TIP1  Seripauperin and TIP1 family


Domain annotation for each model (and alignments):
>> SRP1_TIP1  Seripauperin and TIP1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       0.1   1.8e+03      51      67 ..     321     337 ..     305     358 .. 0.84
   2 ?   11.0   0.1   1.8e-05      0.33      10      58 ..     397     448 ..     389     468 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.1
   SRP1_TIP1  51 alatatddsYttllsei 67 
                 +l ++td+++ t+++++
  EFC38951.1 321 ELHQKTDKDFETFFTKF 337
                 56678899999999875 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 1.8e-05
   SRP1_TIP1  10 aevaelevllnDvksnl.keYlslaka.nsgfs.lPsgvlsvyaalatatdd 58 
                 a ++ ++ l++D+  ++ + Y +++++ n++++ lP++v ++ ++++++t++
  EFC38951.1 397 AHIELVKQLVADFLGHMyNHYCAFITNiNNNQNaLPPKVNQLRMNYYAKTQK 448
                 667788999***99998578******99666666***********9888843 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (479 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      525  (0.0292822); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.26s 00:00:00.87 Elapsed: 00:00:00.42
# Mc/sec: 3413.29
//
Query:       EFC38952.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       671  (0.0374254); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.57
# Mc/sec: 662.62
//
Query:       EFC38953.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.7e-19   69.0   0.0    6.7e-19   68.2   0.0    1.4  1  ADH_zinc_N    Zinc-binding dehydrogenase
    4.6e-17   61.9   0.0    1.1e-16   60.7   0.0    1.7  1  ADH_N_2       N-terminal domain of oxidoreductase
    2.5e-09   38.3   0.0    7.2e-09   36.8   0.0    1.8  2  ADH_zinc_N_2  Zinc-binding dehydrogenase


Domain annotation for each model (and alignments):
>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.2   0.0   1.1e-22   6.7e-19       1     129 [.     235     374 ..     235     375 .. 0.84

  Alignments for each domain:
  == domain 1  score: 68.2 bits;  conditional E-value: 1.1e-22
                 HHHHHHHHHHHHTT-EEEEEE.SSHHHHHHHHHTTESEEEET....TTC.HHHHHHHHHTTTSSEEEEEESSCSHHHHHHHHHCEEEEEEEEECSCTSS CS
  ADH_zinc_N   1 gvGlaavqlAkalGaeviavd.sseeklelakklGadeviny....kea.dlverikeltggegvdvvfecvGsgatleaalkllkpgGrlvvvGggkg 93 
                 +vG+++ q+Ak  G+ vi+++ +see  + +k+ G d +iny    + + +l+ +i+++   + vd +f+ vG g  l+a + ++++ Gr+ ++G+ ++
  EFC38953.1 235 AVGSIVGQIAKLKGCFVIGISgGSEEAMKELKSAGFDSLINYkdypS-TsTLKTAIEKASPSKEVDCYFDNVG-GYILDAVTLCMAKYGRMSLCGAISQ 331
                 69*****************661577788**************66641.33699***999999***********.**********************555 PP

                 EEE......EEHHHHH.HTT-EEEEE-SSCHHHHHHHHHHHHH CS
  ADH_zinc_N  94 eee......fdlrnll.lkeksilGsllgslreefkealdlla 129
                  ++       +++ l   +e++++G+l +s++++++ea++ la
  EFC38953.1 332 YNDtgaemgPRMNSLYvVRELKVQGFLISSYQKRYQEAVQQLA 374
                 555466655333335559*******************999776 PP

>> ADH_N_2  N-terminal domain of oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.7   0.0   1.8e-20   1.1e-16       3      97 ..      69     171 ..      67     183 .. 0.82

  Alignments for each domain:
  == domain 1  score: 60.7 bits;  conditional E-value: 1.8e-20
     ADH_N_2   3 wvlkkrpegaptesdfeleeeelpel..kdGe.vlvralylSvDPymRgrmnda..ksyvepvelgdvmrggavgeVveSk...npdfkvGdlVvgllg 93 
                 ++++k p+g+++esdf++++++  ++   +G+ ++++ l lSvDPymR rm  +  k y + ++l++++ gg++++V+ S    + ++k+Gdl  g+ +
  EFC38953.1  69 ILMNKFPKGMIEESDFKIVQVDFEQPlaSEGDwIVIKLLQLSVDPYMRARMAPKtpKGYFPAFKLNEPLHGGCIAKVLSSStsvQHRYKQGDLLFGYFN 167
                 788999**************9987662245534899***************9653489*******************9776222689************ PP

     ADH_N_2  94 wqdy 97 
                 wq  
  EFC38953.1 168 WQLV 171
                 *974 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.8     1e+04      35      54 ..     211     231 ..     200     248 .. 0.68
   2 !   36.8   0.0   1.2e-12   7.2e-09       2     133 .]     269     414 ..     268     414 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.8
                   H.HHHHHHE.EEEEEEEE--- CS
  ADH_zinc_N_2  35 lleaslkvl.pggGrlvsigg 54 
                   +++  l+++ p++G +v++++
    EFC38953.1 211 AYHGFLDICqPKKGEVVVVSA 231
                   446677888788899988774 PP

  == domain 2  score: 36.8 bits;  conditional E-value: 1.2e-12
                   T-SEEEETTSTTHH........HHH-TT-EEEEEES-HHHHH.HHHHHHEEEEEEEEE----........S-EEE-CHHHCTTT-EEEE--GGG... CS
  ADH_zinc_N_2   2 GAdevidyrtedfe........aatggegvDvvldtvggealleaslkvlpggGrlvsiggpp.......lsaallkpakkrkgrsvkyeflfsmka 83 
                   G+d  i+y++   +        +a  ++ vD  +d+vgg  l +a+  +++++Gr+   g  +       +  + +++++    r +k++ ++ +++
    EFC38953.1 269 GFDSLINYKDYPSTstlktaieKASPSKEVDCYFDNVGGYIL-DAVTLCMAKYGRMSLCG-AIsqyndtgAEMGPRMNSL-YVVRELKVQGFL-ISS 361
                   77788855533333355677764434588*********9988.8888788*****93333.2334577774444444444.445555555555.555 PP

                   -...-HHHHHHHHHHHHHHH----EEEEEEGGGHHHHHHHHHSS--S.SEEEE CS
  ADH_zinc_N_2  84 s..aqadileelaalieeGklrpvvdrvfpleeaaeAhrylesgrar.GKiVl 133
                   +  + +++ ++la++  eGkl+   ++v ++e++++A+ +l sg  + GK+++
    EFC38953.1 362 YqkRYQEAVQQLAQWTLEGKLKALETKVKGFENTPKAIIRLFSGEQKlGKMIV 414
                   56667777*********************************9998877**997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      635  (0.0354175); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.37s 00:00:01.06 Elapsed: 00:00:00.56
# Mc/sec: 2263.46
//
Query:       EFC38954.1  [L=533]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.058   13.2   0.2       0.34   10.7   0.0    2.4  3  SGTA_dimer  Homodimerisation domain of SGTA


Domain annotation for each model (and alignments):
>> SGTA_dimer  Homodimerisation domain of SGTA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   1.9e-05      0.34      19      56 ..     182     219 ..     177     223 .. 0.85
   2 ?   -2.8   0.0      0.31   5.5e+03      34      44 ..     292     302 ..     292     303 .. 0.86
   3 ?   -2.9   0.0      0.35   6.2e+03      32      48 ..     512     528 ..     511     530 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 1.9e-05
  SGTA_dimer  19 dgtvseDdaESleVAiqCIaeaFevdkedkaavkkakf 56 
                 +  +++++   +e A+q I e Fe+  ed+++ kk+k 
  EFC38954.1 182 KMLIPSEYSQFIELAVQVIDENFELPSEDSESLKKKKN 219
                 55688999999********************9997773 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.31
  SGTA_dimer  34 iqCIaeaFevd 44 
                 ++ Ia++F v+
  EFC38954.1 292 MDGIADSFAVS 302
                 689*****996 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 0.35
  SGTA_dimer  32 VAiqCIaeaFevdkedk 48 
                 VA + +  aF+++  d+
  EFC38954.1 512 VALNILNGAFNIQYIDE 528
                 89999999**9987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (533 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       864  (0.0481901); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.35s 00:00:01.10 Elapsed: 00:00:00.56
# Mc/sec: 2866.17
//
Query:       EFC38955.1  [L=302]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-32  110.8   0.0      8e-32  110.1   0.0    1.3  1  Ras          Ras family
    3.5e-18   65.9   0.0    7.1e-18   65.0   0.0    1.5  1  Roc          Ras of Complex, Roc, domain of DAPkinase
    0.00017   21.1   0.0    0.00025   20.5   0.0    1.4  1  Arf          ADP-ribosylation factor family
     0.0018   17.7   0.0     0.0046   16.4   0.0    1.7  2  Gtr1_RagA    Gtr1/RagA G protein conserved region
     0.0057   16.6   0.0      0.024   14.5   0.0    1.8  2  RsgA_GTPase  RsgA GTPase
  ------ inclusion threshold ------
      0.021   15.2   0.0       0.32   11.5   0.0    2.4  2  Tfb2_C       Transcription factor Tfb2 (p52) C-terminal domai


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  110.1   0.0   2.7e-35     8e-32       1     160 [.     108     283 ..     108     285 .. 0.88

  Alignments for each domain:
  == domain 1  score: 110.1 bits;  conditional E-value: 2.7e-35
                 EEEEEESTTSSHHHHHHHHHHSS....CSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdk....FkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwv 94 
                 K+++ G++avGKtsl+++   +k    F+ + e  ig   y ++++  +k v+l++wDTAGq ++++lr+l+y  ++++ +++   s++sf+++  +wv
  EFC38955.1 108 KIIICGEGAVGKTSLIHKLYYGKipeyFPGNCELEIGYG-YLNNVT-MNKFVTLTLWDTAGQKDYDKLRPLSYPYTDVFCICFTRISSKSFKKIPsRWV 204
                 89***************9987761111555555555443.344444.4789*******************************************99*** PP

                 HHHHHHSTTTSEEEEEEETTTGGG.............G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  95 eeikrvaeenvpivLvGnKvDlee.............kravsteegeelakelg.lkfletSAktnenveeafeellrei 160
                  ei+++a+ n ++vL+G K Dl +             + av++e++ ++ak++g l+++etSA t e+    f e+++++
  EFC38955.1 205 PEINHHAP-NSALVLIGCKFDLLSdtdvitklryrhfDSAVKYENSVQMAKNIGaLTYIETSALTGEGNVSDFAEIITKC 283
                 ********.69***********999*****************************9***********99989999998875 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.0   0.0   2.4e-21   7.1e-18       1     119 [.     108     224 ..     108     225 .. 0.84

  Alignments for each domain:
  == domain 1  score: 65.0 bits;  conditional E-value: 2.4e-21
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCH. CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenl. 95 
                 K++++G+++vGKtsl++++  +k+ e     + +++    +++++        k v+l +WDtaGq+++++l+pl +   ++++++++   s+s++++ 
  EFC38955.1 108 KIIICGEGAVGKTSLIHKLYYGKIPEYFPGNCELEIGYGYLNNVT------MNKFVTLTLWDTAGQKDYDKLRPLSYPYTDVFCICFTrisSKSFKKIp 200
                 9********************999888887777777665543332......235699*****************9999999999998766566677774 PP

                 HHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  96 keWlkelkkvagkspvilvgnkiD 119
                 ++W+ e++++a++s ++l+g k D
  EFC38955.1 201 SRWVPEINHHAPNSALVLIGCKFD 224
                 68********************99 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   8.4e-08   0.00025       7     119 ..      99     218 ..      93     283 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 8.4e-08
                 GGTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSS.....SSE.EEEEEEE.TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHH CS
         Arf   7 klklkkkelrilllGLDnaGKtTilkklkleelvttvPT.....igf.nveelei.knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRle 98 
                 +++++k  l+i++ G  + GKt +++kl  +++ +  P      ig+   +++++ k +++t+wD  Gq+   +l    ++ td+   +     ++ ++
  EFC38955.1  99 QIEKQKSRLKIIICGEGAVGKTSLIHKLYYGKIPEYFPGnceleIGYgYLNNVTMnKFVTLTLWDTAGQKDYDKLRPLSYPYTDVFCICFTRISSKSFK 197
                 556668899**************************999632222333124566653668**********976666666666677666666666666666 PP

                 HHHHHHHHHCTSGCCTTSEEE CS
         Arf  99 eakeeLkalleeeelkevall 119
                 +  +     ++++  +++ +l
  EFC38955.1 198 KIPSRWVPEINHHAPNSALVL 218
                 665555555555555544444 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   1.5e-06    0.0046       1      62 [.     108     171 ..     108     188 .. 0.82
   2 ?   -3.0   0.0       1.3   3.8e+03      72      82 ..     251     261 ..     205     289 .. 0.61

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.5e-06
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardt...lrlgatidveksevrflgnltlnlwDcgGqeafv 62 
                 k++++G++  GKts+   ++   +++      +l++      ++v +++++tl lwD  Gq+++ 
  EFC38955.1 108 KIIICGEGAVGKTSLIHKLYYGKIPEYFpgnCELEIGYGY-LNNVTMNKFVTLTLWDTAGQKDYD 171
                 899***********99999998888754222678877765.57788****************985 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.3
   Gtr1_RagA  72 eifrnvgvliy 82 
                 ++ +n+g+l y
  EFC38955.1 251 QMAKNIGALTY 261
                 33344444444 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   8.2e-06     0.024      63     120 ..      70     127 ..      47     133 .. 0.83
   2 ?   -0.8   0.0      0.41   1.2e+03      49      91 ..     216     254 ..     188     273 .. 0.65

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 8.2e-06
                  HHHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTTSEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  63 eeleelkeelealgyevllvsaktkegleelkellkdktsvlvGqSGvGKStLinall 120
                  ++ e+lk+++ ++++   + + k++ ++e+++++ +   ++++G+  vGK++Li +l 
   EFC38955.1  70 KQEEALKTKFDTVELYRPFQEIKNSINVEQIEKQKSRLKIIICGEGAVGKTSLIHKLY 127
                  2557888888999988888889999************999**************9985 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.41
                  EEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTTHTTHH CS
  RsgA_GTPase  49 pvivlnKiDlleeeeeleelkeelealgyevllvsaktkegle 91 
                  +v++  K Dll++++    +k ++++++ +v + ++   + ++
   EFC38955.1 216 LVLIGCKFDLLSDTD--VITKLRYRHFDSAVKYENSV--QMAK 254
                  555567999999999..44455666666666544333..3333 PP

>> Tfb2_C  Transcription factor Tfb2 (p52) C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.23   6.9e+02      20      52 ..      75     107 ..      69     116 .. 0.80
   2 ?   11.5   0.0   0.00011      0.32      21      45 ..     237     261 ..     235     268 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.23
      Tfb2_C  20 lyddFesqadfeevleyakelgvllwedeekrl 52 
                 l ++F++ + ++  +e+ ++++v + e++++rl
  EFC38955.1  75 LKTKFDTVELYRPFQEIKNSINVEQIEKQKSRL 107
                 557899999999999999999999988776653 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.00011
      Tfb2_C  21 yddFesqadfeevleyakelgvllw 45 
                 y++F+s+ ++e+ +++ak++g+l +
  EFC38955.1 237 YRHFDSAVKYENSVQMAKNIGALTY 261
                 99********************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       799  (0.0445647); expected 358.6 (0.02)
Passed bias filter:                      475  (0.0264934); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 1741.51
//
Query:       EFC38956.1  [L=261]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.027   14.3   0.1      0.054   13.4   0.1    1.5  1  DUF4939   Domain of unknown function (DUF4939)


Domain annotation for each model (and alignments):
>> DUF4939  Domain of unknown function (DUF4939)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1     3e-06     0.054      37     103 ..      35     103 ..      26     109 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3e-06
     DUF4939  37 drlp.efivqtlsymlvdektfssdalkvtflitrltGealewv..lpyikkdspllndyrafl..aemkrv 103
                 +++p e iv+++sy+lv++ ++   + +v f  t+l G+ l  +  ++ i k+s +  +    l  +e+k++
  EFC38956.1  35 EKVPaEIIVKIMSYLLVNDVNYFGQSCRVYF--TLLFGQDLSRLksIQQI-KKSFVWRNMEEILkcNELKKE 103
                 5666599**********************99..56777766543113333.345555555555433555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       986  (0.0549947); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.37s 00:00:00.96 Elapsed: 00:00:00.56
# Mc/sec: 1403.40
//
Query:       EFC38957.1  [L=648]
Description: hypothetical protein NAEGRDRAFT_73252 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   5.7e-261  867.0   8.6   6.5e-261  866.8   8.6    1.0  1  HSP70           Hsp70 protein
    1.8e-18   66.5   5.0    3.9e-17   62.1   0.0    3.0  3  MreB_Mbl        MreB/Mbl protein
     0.0047   16.2   0.1      0.031   13.5   0.1    2.1  2  Hydantoinase_A  Hydantoinase/oxoprolinase
  ------ inclusion threshold ------
      0.025   13.8   2.2       0.25   10.6   0.5    2.4  2  EAP30           EAP30/Vps36 family
      0.031   14.7   0.6         12    6.4   0.0    3.4  3  FtsA            Cell division protein FtsA
      0.033   13.2   1.5       0.46    9.4   0.1    2.7  3  DDR             Diol dehydratase reactivase ATPase-like domai
      0.069   12.6   0.0          4    6.8   0.0    2.4  2  BcrAD_BadFG     BadF/BadG/BcrA/BcrD ATPase family
        1.1    9.5   6.1         14    5.9   1.6    2.8  2  Cys_rich_FGFR   Cysteine rich repeat


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  866.8   8.6  2.9e-264  6.5e-261       1     599 []      10     611 ..      10     611 .. 0.98

  Alignments for each domain:
  == domain 1  score: 866.8 bits;  conditional E-value: 2.9e-264
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXTTSEEETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHHHTTXSSEEEEETTSBEEE CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrttPsvvaFtkkerlvGeaAkrqavtnpkntvfsvKrliGrkfsdpevqkeikelpykvvkkengkavv 99 
                 +iGiDLGtt+s+v+v  g+++e+i n++gnrttPs+vaFt++erl+G+aAk+q+++np+ntvf++KrliGrkfsd++vq ++k++p+kv +k+++k+++
  EFC38957.1  10 AIGIDLGTTYSCVGVYMGDNVEIIPNDQGNRTTPSYVAFTDEERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFSDSTVQDDMKHWPFKVITKSDEKPYI 108
                 59************************************************************************************************* PP

                 EEEETTE..EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSSSCEEEEEEEEXSS CS
       HSP70 100 eveaage..kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkdkernvlvyDlGgg 196
                 +ve++ge   ftpeqis+mvL+k+k++ e+ylgk+v++avitvPaYfnd+qRqatkdAg+iAGL+vlRi+NepTAaa+aYGl+kk  ernvl++DlGgg
  EFC38957.1 109 QVEYKGEshVFTPEQISSMVLTKMKDISEQYLGKQVKKAVITVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKG-ERNVLIFDLGGG 206
                 *******999***************************************************************************9.************ PP

                 XEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTEEEEEEEEH CS
       HSP70 197 tfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrlkeaaekaKkeLSsskqteinleietvdedgkdlseklsR 295
                 tfdvSil++e+GvfevkaTagDthlGGedfD+ +v+++++efk+k++ d++++++al+rl++a+e+aK++LSs  +++++++++++++ g dl+++++R
  EFC38957.1 207 TFDVSILNIEDGVFEVKATAGDTHLGGEDFDNLMVQFCCQEFKRKYKKDIQENPRALRRLRTACERAKRNLSS--AANASINVDSIMD-GIDLDISMTR 302
                 *************************************************************************..899999******9.********** PP

                 HHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTT.CHHBSSSHTTTHHHHHHHHHHHHHCTCGCSHCCEEEEBESS- CS
       HSP70 296 akfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfg.kepsktvnpDeavaiGAAvqagvlsgeeevkdllllDvtpLs 393
                 akfe+l++dl++++ epv+k+l+d++l+k +id+vvlvGGstRiPkvqe+++e+f+ ke+++++npDeava+GAAvq+gvl+g  + +++ll DvtpLs
  EFC38957.1 303 AKFEQLNMDLFKKCFEPVKKVLQDSGLDKAQIDDVVLVGGSTRIPKVQEMLREFFNgKELCRSINPDEAVAYGAAVQGGVLTG--KETKVLLIDVTPLS 399
                 *******************************************************99**************************..9999********** PP

                 EEEEETTTEEEEEESTTCBSSEEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEEEEETTTCCEE CS
       HSP70 394 lgietlggvmtkliernttiptkksqvfstaadnqtaveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvsakdketgkee 492
                 lgiet+ggvmtkliern tip kks++fst+adnqtav+i+v++ger+l+kdn+llg+f+l+gippaprGvp+ieVtf+id nGi++vsakd+++gk++
  EFC38957.1 400 LGIETAGGVMTKLIERNSTIPCKKSEIFSTYADNQTAVTIQVFEGERTLTKDNHLLGRFNLEGIPPAPRGVPKIEVTFEIDSNGIMKVSAKDTSSGKTQ 498
                 *************************************************************************************************** PP

                 EEEEECCSS.SBHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..GGGSTHHHH....HHHHHHHHHHHCHTTSSCHHHHHHHHH CS
       HSP70 493 eitieaseg.lseeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleee..aekvseaek....ekvesaieeLkeeleeeekeeieakte 584
                 +iti++++g ls+eeie+mvk+a+e+++ dk+ ke+i+akn++e+++y+++++ ++   + k+s+a+k    ++ e+ i++L+++ ++ +k++ie+k++
  EFC38957.1 499 NITIKNEQGrLSKEEIEEMVKKAKEMEQFDKELKEKIDAKNQLEAYAYQMKSTADDPnlSGKLSDADKntikKTCEEVINWLDNN-STYSKDDIEKKRK 596
                 *********9*********************************************988999*******55555555666666666.45669******** PP

                 HHHHHHHHHHHHHHH CS
       HSP70 585 elkkvvekiaeklye 599
                 el+  + +i++kly+
  EFC38957.1 597 ELEGKCAPIVSKLYQ 611
                 **********99986 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.022        50       3      50 ..      10      63 ..       8      80 .. 0.64
   2 !   62.1   0.0   1.7e-20   3.9e-17      76     316 ..     126     377 ..     118     384 .. 0.81
   3 ?    2.0   0.8     0.032        71     212     271 ..     477     534 ..     470     539 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.022
                EEEEEE-SSEEEE..EETTTEEEE.......EEES-EEEETTT--EEEESHHHHTTT CS
    MreB_Mbl  3 dlgiDLGtantlv..yvkgkgivl.......nepsvvAikkktkkvlavGeeAkkml 50
                 +giDLGt+   v  y+ ++  ++       + ps vA++ +++    +G+ Ak+ +
  EFC38957.1 10 AIGIDLGTTYSCVgvYMGDNVEIIpndqgnrTTPSYVAFTDEER---LIGDAAKNQV 63
                69******998865588887655522222222477777765544...3466666555 PP

  == domain 2  score: 62.1 bits;  conditional E-value: 1.7e-20
                 HHHHHHHHHHHTSS-S.S--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-EEEEEEETTEEE..... CS
    MreB_Mbl  76 ellkyfikkvkkkksl.skprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglpveepsgnmvvdiGggttevavislggiv..... 168
                 +++ + +k+++++    + ++ vi+vP   ++ +r+A k+a   aG +   +i+ep aAAi  gl+ +  +  ++ d+Gggt +v+++ + + v     
  EFC38957.1 126 SMVLTKMKDISEQYLGkQVKKAVITVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKGERNVLIFDLGGGTFDVSILNIEDGVfevka 224
                 5555666666665443256789*******************************************************************9987622222 PP

                 EEEEES-SHHHHHHHHHHHH....HHHHSEE--HH..HHHHHHHHH-BSS--HHHH.EEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHHHHH CS
    MreB_Mbl 169 tsksvrvaGdeldeaiikyi....rkkynlliGer..taekikieigsavkeeeee.kmeikGrdlvtglpkevevsseevrealkepvsaiveavkev 260
                 t+   +++G+++d+ ++++     ++ky+  i e+    ++++++   a+ + ++  + +i+   ++ g+   ++++ ++ ++   + +++  e vk+v
  EFC38957.1 225 TAGDTHLGGEDFDNLMVQFCcqefKRKYKKDIQENprALRRLRTACERAKRNLSSAaNASINVDSIMDGIDLDISMTRAKFEQLNMDLFKKCFEPVKKV 323
                 2345789**********9963333788888888751144566666666655544447999*************************************** PP

                 HHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS-.EEE-SSTTTHHHHHHH CS
    MreB_Mbl 261 LektppeLaadivdrgivltGGgallkgldkllseetglp.vkvaedpltcvakGtg 316
                 L++   + a   +d  +vl+GG++ +  ++++l+e ++ +    + +p ++va G++
  EFC38957.1 324 LQDSGLDKA-Q-ID-DVVLVGGSTRIPKVQEMLREFFNGKeLCRSINPDEAVAYGAA 377
                 **9876643.3.44.58999***************9876515567789999999875 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.032
                 S--HHHHEEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHTS-HHHHHH CS
    MreB_Mbl 212 vkeeeeekmeikGrdlvtglpkevevsseevrealkepvsaiveavkevLektppeLaad 271
                 ++ +++  m+++ +d  +g  +++++++e+ r   ke+++++v+++ke +e+   eL   
  EFC38957.1 477 FEIDSNGIMKVSAKDTSSGKTQNITIKNEQGR-LSKEEIEEMVKKAKE-MEQFDKELKEK 534
                 555666789******************99866.457888999988876.57777777665 PP

>> Hydantoinase_A  Hydantoinase/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.1   1.4e-05     0.031      24     103 ..     142     222 ..     124     231 .. 0.71
   2 ?   -0.5   0.0      0.26   5.9e+02     225     282 ..     316     376 ..     299     379 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.4e-05
  Hydantoinase_A  24 kslekrgakarlmvmqsdGglv.sadearkkpvetilSGPaaGvvgaaatsklagekkvItfDmGGTstDvsl..ikdgevev 103
                     k+++k+ ++ + ++ +s+   + +a ++ +  v  i+  P a ++++    +++ge++v+ fD+GG ++Dvs   i+dg +ev
      EFC38957.1 142 KQVKKAVITVPAYFNDSQRQATkDAGAIAGLEVLRIINEPTAAAIAYGL--NKKGERNVLIFDLGGGTFDVSIlnIEDGVFEV 222
                     5555555556666666665543255666666677788889888888888..99*****************9962255666655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.26
  Hydantoinase_A 225 manavrklsvergldpkeltlvvfGGaG...aqhaaalaeelgvkkvivppyagvlsalGm 282
                       ++v+k++++ gld+ +   vv  G++   + + ++l e ++ k+      +  ++a+G+
      EFC38957.1 316 CFEPVKKVLQDSGLDKAQIDDVVLVGGStriPKVQEMLREFFNGKELCRSINPDEAVAYGA 376
                     5688999*********999988876666344445555555566665555555555555555 PP

>> EAP30  EAP30/Vps36 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.039        87      29      67 ..     234     270 ..     226     310 .. 0.80
   2 ?   10.6   0.5   0.00011      0.25      29      68 ..     512     550 ..     483     597 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.039
       EAP30  29 qdleallakfkesLvklaekhkakiksdpafraqftkmc 67 
                 +d ++l+ +f    +++ +k+k++i+++p   ++ ++ c
  EFC38957.1 234 EDFDNLMVQFCC--QEFKRKYKKDIQENPRALRRLRTAC 270
                 577888888887..99*************9777766644 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00011
       EAP30  29 qdleallakfkesLvklaekhkakiksdpafraqftkmca 68 
                 +++e++ +k+ke ++++ +++k+ki ++++ +a   +m +
  EFC38957.1 512 EEIEEMVKKAKE-MEQFDKELKEKIDAKNQLEAYAYQMKS 550
                 689*********.*****************9998888755 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0051        12       1      32 [.      11      40 ..      11     171 .. 0.86
   2 ?    4.5   0.0      0.02        45       4      89 ..     202     360 ..     199     379 .. 0.59
   3 ?   -0.6   0.0       0.8   1.8e+03      40      52 ..     513     525 ..     393     600 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0051
                EEEEE-SSSEEEEEEETTEEEEEEEES-.-HHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx RF
        FtsA  1 alvDiGagktdvavaedgalvhlrvigv.ggng 32
                +++D+G++ ++v v+ ++   ++++i+  +gn 
  EFC38957.1 11 IGIDLGTTYSCVGVYMGD---NVEIIPNdQGNR 40
                58***************7...888888765554 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.02
                 EE-SSSEEEEEEETTEEEE.....EEEES-....-HHHHHHH......................HHHHHT--HHHHHHHHHHH--S--........... CS
                 xxxxxxxxxxxxxxxxxxx.....xxxxxx....xxxxxxxx......................xxxxxxxxxxxxxxxxxxxxxxxx........... RF
        FtsA   4 DiGagktdvavaedgalvh.....lrvigv....ggngitkd......................iakalrtaveeAerikikyGsala........... 60 
                 D+G+g+ dv++++ +  v+               gg+ +++                       + + lrta e A+r   + +   +           
  EFC38957.1 202 DLGGGTFDVSILNIEDGVFevkatA----GdthlGGEDFDNLmvqfccqefkrkykkdiqenprALRRLRTACERAKRNLSSAA---Nasinvdsimdg 293
                 7777777777777654332333231....1223344444444555555555555666677766666777777777777773322...223355555555 PP

                 ...EEEEEHHHHH...........................................GGGGSTTHHHHHHHHHT-. CS
                 ...xxxxxxxxxx...........................................xxxxxxxxxxxxxxxxxxx RF
        FtsA  61 ...ekeigrkels...........................................ggsalpnleelaeralspk 89 
                    +                                                    g++ +p+++e++++ ++ k
  EFC38957.1 294 idlD--------IsmtrakfeqlnmdlfkkcfepvkkvlqdsgldkaqiddvvlvgGSTRIPKVQEMLREFFNGK 360
                 5441........044444455666777777777888888888888888888889999999999999999998543 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.8
                 HHT--HHHHHHHH CS
                 xxxxxxxxxxxxx RF
        FtsA  40 alrtaveeAerik 52 
                  + + v++A++++
  EFC38957.1 513 EIEEMVKKAKEME 525
                 2333344444444 PP

>> DDR  Diol dehydratase reactivase ATPase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1   0.00021      0.46     132     166 ..     195     228 ..     170     231 .. 0.81
   2 ?    1.6   0.0     0.049   1.1e+02     273     296 ..     332     355 ..     307     364 .. 0.82
   3 ?   -2.0   0.2      0.61   1.4e+03      84     113 ..     513     541 ..     482     550 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00021
         DDR 132 ekplailDlGaGstDaalieeegevkavhlAGAGe 166
                 e+++ i DlG+G+ D ++++ e+ v  v  A AG+
  EFC38957.1 195 ERNVLIFDLGGGTFDVSILNIEDGVFEVK-ATAGD 228
                 56799***************999998864.77776 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.049
         DDR 273 rdidfvvlvGgsalDfEipelvtd 296
                  +id vvlvGgs+    ++e++ +
  EFC38957.1 332 AQIDDVVLVGGSTRIPKVQEMLRE 355
                 5899********988888888766 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.61
         DDR  84 glaamvktdklqmqkiaeeleeelgvkvev 113
                  + +mvk +  +m++  +el+e+++ k ++
  EFC38957.1 513 EIEEMVK-KAKEMEQFDKELKEKIDAKNQL 541
                 4667774.4557888888888887777665 PP

>> BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0    0.0018         4       1      50 [.      11      61 ..      11      91 .. 0.94
   2 ?    3.3   0.0     0.022        48     202     265 ..     320     378 ..     266     380 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0018
                 EEEEE-SS.EEEEEEEETTTEEEEEEEE--TTS-HHH.........HHHHH CS
  BcrAD_BadFG  1 vGiDgGsT.ttkavlmdekgevlgrgitnsanlesvrfeaaekvleealte 50
                 +GiD+G+T ++  v m ++ e++ + + n +  + v f++ e+ + +a ++
   EFC38957.1 11 IGIDLGTTySCVGVYMGDNVEIIPNDQGNRTTPSYVAFTDEERLIGDAAKN 61
                 7*******889**********************************999875 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.022
                  HHHHHHHHHHTT---SS.EEEESGGGG-HHHHHHH.....HHHH-S-EE--GGGGGHHHHHHHH CS
  BcrAD_BadFG 202 ialrvialisrsggvtdevtltGGvakneaavkelrklvkenygevkininpdsiytgalGAal 265
                  +++ +       +++ d+v+l+GG  +  + v   ++++ e +++++   ++ ++ + a GAa+
   EFC38957.1 320 VKKVLQDSGLDKAQI-DDVVLVGGSTRI-PKV---QEMLREFFNGKELCRSINPDEAVAYGAAV 378
                  444444444444445.339999999999.434...34478888888888999999999999985 PP

>> Cys_rich_FGFR  Cysteine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   1.6    0.0063        14       3      30 ..     245     272 ..     244     275 .. 0.96
   2 ?    4.9   0.2     0.014        30      10      39 ..     544     576 ..     538     602 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0063
  Cys_rich_FGFR   3 CkqlllrlqeevaeDykldpkLqkaCkd 30 
                    C++ ++++++++ e+ ++ + L +aC++
     EFC38957.1 245 CQEFKRKYKKDIQENPRALRRLRTACER 272
                    **************************96 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.014
  Cys_rich_FGFR  10 l...qeevaeDykldpkLqkaCkddiekfCsdi 39 
                    +   ++  a+D +l+ kL++a k+ i+k C+++
     EFC38957.1 544 YayqMKSTADDPNLSGKLSDADKNTIKKTCEEV 576
                    4445778899********************874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (648 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1945  (0.108483); expected 358.6 (0.02)
Passed bias filter:                      885  (0.0493614); expected 358.6 (0.02)
Passed Vit filter:                        92  (0.00513135); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.90u 0.43s 00:00:01.33 Elapsed: 00:00:00.59
# Mc/sec: 3315.69
//
Query:       EFC38958.1  [L=125]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0055   16.4   3.9     0.0096   15.7   3.9    1.4  1  AT_hook   AT hook motif


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   3.9   5.3e-07    0.0096       1      11 [.     112     122 ..     112     123 .. 0.93

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 5.3e-07
     AT_hook   1 kRkRGRPrKaa 11 
                 kR+RGRPrK++
  EFC38958.1 112 KRGRGRPRKNS 122
                 8********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (125 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       848  (0.0472977); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.49
# Mc/sec: 764.37
//
Query:       EFC38959.1  [L=686]
Description: hypothetical protein NAEGRDRAFT_81447 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.9e-06   25.8   4.9    2.1e-05   24.8   4.9    1.6  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   4.9   1.2e-09   2.1e-05       6      88 ..     560     640 ..     555     676 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 1.2e-09
                 HTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTT CS
         RGS   6 ledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrk 88 
                 l +++++++++e+ e+efs+en +F+++ + ++++  +   +k+ +eI  e++ + s+ e+ni+++++++  + l+k q+ ++
  EFC38959.1 560 LTNSDLLQILKEYSEKEFSSENYEFYIKLKSLQNR--KFIKLKELQEIEAEFIRNYSKYEVNIPSSCKKTFYELLNKCQEESQ 640
                 78999*****************************9..6667889**************************9999999755444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (686 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1006  (0.0561102); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.46
# Mc/sec: 4492.57
//
Query:       EFC38960.1  [L=199]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (199 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       308  (0.0171789); expected 358.6 (0.02)
Passed bias filter:                      263  (0.014669); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.40u 0.27s 00:00:00.67 Elapsed: 00:00:00.41
# Mc/sec: 1443.50
//
Query:       EFC38961.1  [L=268]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5121  (0.285627); expected 358.6 (0.02)
Passed bias filter:                     1362  (0.0759663); expected 358.6 (0.02)
Passed Vit filter:                       801  (0.0446762); expected 17.9 (0.001)
Passed Fwd filter:                       331  (0.0184617); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 3.91u 0.40s 00:00:04.31 Elapsed: 00:00:00.81
# Mc/sec: 1001.68
//
Query:       EFC38962.1  [L=286]
Description: FabG domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      2e-16   60.1   0.0    9.9e-15   54.5   0.0    2.2  2  adh_short     short chain dehydrogenase
    1.3e-11   44.5   0.0    2.3e-11   43.7   0.0    1.3  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    2.1e-05   24.5   0.0    5.3e-05   23.2   0.0    1.7  2  KR            KR domain
     0.0024   17.0   0.0     0.0034   16.6   0.0    1.2  1  PAE           Pectinacetylesterase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.5   0.0   2.2e-18   9.9e-15       1     137 [.       4     144 ..       4     153 .. 0.83
   2 ?    3.3   0.0     0.011        50     160     186 ..     179     205 ..     171     211 .. 0.88

  Alignments for each domain:
  == domain 1  score: 54.5 bits;  conditional E-value: 2.2e-18
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGGCS CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfsels 97 
                 k +l +G++sGIGra+a ++a++ ++v +++rsee+ +e+++e+k++  + k+ +i+vD + ++++e++ e+ ++++++ld  v   Gi+ ++   +++
  EFC38962.1   4 KQALCVGGTSGIGRALAIKFASQKFNVSIMGRSEEAGKEIIEEMKKLnpEGKFEMIKVDASLMKDIEKVCEEYKQNHDRLDYCVLSQGIASMNG--RTE 100
                 57899******************************************9999**************************************54443..444 PP

                 HHH.HHHHHHHHTHHHHHHHHHHHHHHH...HCTTEEEEEEEEG CS
   adh_short  98 eee.wervievNltgvflltravlpaml...kqssGrIvnvsSv 137
                  +e ++  +++ + g ++ +r++ + +    k+s  r+ +v S 
  EFC38962.1 101 TKEgIDVKLALHYYGRVMFVRQLQDLLRltsKNSDVRVLTVLSA 144
                 44447777888888888888777666656556666666666665 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.011
                 HHHHHHHHGGGTEEEEEEEESSBSSHH CS
   adh_short 160 trslakelaptgirvnavaPGlvdTdm 186
                 +++l+ke  +++i  +  aPG+v+T+ 
  EFC38962.1 179 MDQLSKEEGNQNIAFIHQAPGIVATQW 205
                 578999*******************86 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.7   0.0   5.2e-15   2.3e-11       3     118 ..      12     128 ..      10     152 .. 0.81

  Alignments for each domain:
  == domain 1  score: 43.7 bits;  conditional E-value: 5.2e-15
                   TTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE.E..EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH-HHHH CS
  adh_short_C2   3 asgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgae.v..lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpfletsreef 95 
                    sgIGra+A ++a++  +v ++ ++eea k+ +ee+++  ++  +  +++D++  +++e++ ee ++++++lD++v + gia   +g+  + ++e++
    EFC38962.1  12 TSGIGRALAIKFASQKFNVSIMGRSEEAgKEIIEEMKKLNPEGkFemIKVDASLMKDIEKVCEEYKQNHDRLDYCVLSQGIASM-NGR--TETKEGI 105
                   69**************************8887777777655434455************************************9.555..5679999 PP

                   HHHHHHHTHHHHHHHHHHHHHCT CS
  adh_short_C2  96 draldvnlyslfllakaalplmk 118
                   d  l+   y+ ++++++++ l++
    EFC38962.1 106 DVKLALHYYGRVMFVRQLQDLLR 128
                   **********9999999998443 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.0   1.2e-08   5.3e-05       4      92 ..       7      93 ..       5     143 .. 0.85
   2 ?   -1.3   0.0       0.4   1.8e+03      80     107 ..     162     189 ..     115     192 .. 0.73

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 1.2e-08
                EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE----- CS
          KR  4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvl 92
                l +GG+ g+G++la   a++ + ++ +++Rs++a ++  +++++l+  + + e++++D s  +++e++ ee+k++++++  ++ + g++
  EFC38962.1  7 LCVGGTSGIGRALAIKFASQ-KFNVSIMGRSEEAGKEIIEEMKKLNP-EGKFEMIKVDASLMKDIEKVCEEYKQNHDRLDYCVLSQGIA 93
                679*************9988.57899*****5555555555555554.449************************99999888776665 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.4
                 S---EEEE---------TTT--HHHHHH CS
          KR  80 ppikGvihaAgvlrdklleemtaedleq 107
                  ++k    aAg+ +d +++++++e+ +q
  EFC38962.1 162 FTLKNAADAAGFYNDLAMDQLSKEEGNQ 189
                 5777778889999999999888887665 PP

>> PAE  Pectinacetylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   7.6e-07    0.0034      96     191 ..      76     177 ..      55     204 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 7.6e-07
         PAE  96 ynwNrvkvrYC...dg.asfsGdveev...dkstklyFrGqrilqaviedLlekglkkakkvlLsGcSAGglaailhcdklrellpkeakvkclsda.G 186
                 y+ N+ ++ YC   +g as +G +e++   d +  l++ G+ ++   ++dLl+   k+++  +L+  SAG  + ++++d+l   l+++ ++k+ +da G
  EFC38962.1  76 YKQNHDRLDYCvlsQGiASMNGRTETKegiDVKLALHYYGRVMFVRQLQDLLRLTSKNSDVRVLTVLSAGVHSPYTKLDDLD--LKHNFTLKNAADAaG 172
                 55566666666443122566777763324477889*********************************************97..8999*****999648 PP

         PAE 187 fFlda 191
                 f+ d 
  EFC38962.1 173 FYNDL 177
                 88765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      514  (0.0286686); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.34s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 1613.12
//
Query:       EFC38963.1  [L=1385]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.3e-18   65.4   3.3    2.5e-09   37.4   0.1    4.6  2  BTB_2      BTB/POZ domain
    8.8e-11   41.5   0.6    1.8e-10   40.5   0.6    1.5  1  G-patch    G-patch domain
     0.0049   16.9   0.1      0.019   15.0   0.1    2.1  1  G-patch_2  G-patch domain


Domain annotation for each model (and alignments):
>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   0.9   2.4e-08   0.00014       1      88 [.      86     223 ..      86     227 .. 0.80
   2 !   37.4   0.1   4.1e-13   2.5e-09       1      87 [.     316     403 ..     316     409 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 2.4e-08
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG.................................................GGEETTTTEEEE-S-HHHHH CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkte.............................................elddydeetneyffDRspklFe 54 
                 v+l VgG+ f+t+ +tL       L++l + e                                               +d  +++   f DR+p++Fe
  EFC38963.1  86 VVLKVGGKFFNTTMRTLVGERGRKLENLDNDEemkegeeekqdedendekeetkdddceyvtaqpnlfkvmfdsgigIERDEANKSAISFPDRNPDYFE 184
                 6788999999999999998888888888887788899999999999999999999999999999999999999987535566666677899******** PP

                 HHHHHHHS.S-B---.....TTS-HHHHHHHHHHHT--T CS
       BTB_2  55 tiLnyyrtggkLhrp.....eevelkslleElefyglee 88 
                 ++L+ +r+ggk++       +  +l+++leE +++  e+
  EFC38963.1 185 YVLEHLRQGGKVKSLgveklNANQLENILEESNYFATEK 223
                 *********998764221115567778889999997666 PP

  == domain 2  score: 37.4 bits;  conditional E-value: 4.1e-13
                 EEEEETTEEEEEEHHHHHTSTTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS...S-B--.-TTS-HHHHHHHHHHHT-- CS
       BTB_2   1 vklnVgGtrfetskstLsrkpdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtg..gkLhr.peevelkslleElefygle 87 
                 vk++V+G +f +   +L+  ++t+L +    +  ++  +e++++f+DRspklF+ i  y+ +g   + ++  ++++ ++l++E+efyg+ 
  EFC38963.1 316 VKIDVSGQIFTIPFAILQ-QHETFLISKYILA-PNFCLNENGCIFIDRSPKLFALIHSYMISGkfTHFPKnLSREKKHQLKQEAEFYGVI 403
                 89***************9.8999998888877.89999999*********************74333333134567789********975 PP

>> G-patch  G-patch domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.5   0.6     3e-14   1.8e-10       2      37 ..    1254    1289 ..    1253    1296 .. 0.92

  Alignments for each domain:
  == domain 1  score: 40.5 bits;  conditional E-value: 3e-14
     G-patch    2 sniGvkmLqkmGWkpGqGLGkkeqGiaePieakikk 37  
                  +++G k+L++mG+++G+GLGk++qG ++Pi+ +++ 
  EFC38963.1 1254 QSVGLKLLKRMGFEQGSGLGKNNQGSVAPISIDKQL 1289
                  699***************************998875 PP

>> G-patch_2  G-patch domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.1   3.3e-06     0.019      16      51 ..    1255    1290 ..    1244    1292 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 3.3e-06
   G-patch_2   16 eFGaAlLrGMGWkegqgigknkkgrvkpeepkrRpg 51  
                  + G  lL+ MG+++g g gkn++g+v+p+ ++++ +
  EFC38963.1 1255 SVGLKLLKRMGFEQGSGLGKNNQGSVAPISIDKQLD 1290
                  56899***********************99988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2051  (0.114396); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.11u 0.35s 00:00:01.46 Elapsed: 00:00:00.54
# Mc/sec: 7704.42
//
Query:       EFC38964.1  [L=1176]
Description: hypothetical protein NAEGRDRAFT_81454 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.4e-11   42.4   4.6    5.4e-11   42.4   4.6    2.2  2  NT-C2         N-terminal C2 in EEIG1 and EHBP1 proteins
    2.6e-06   27.7   0.2    2.6e-06   27.7   0.2    2.7  2  DIL           DIL domain
     0.0005   19.5  56.4     0.0005   19.5  56.4    2.3  3  Tropomyosin   Tropomyosin
     0.0084   15.9  16.7     0.0084   15.9  16.7    4.3  3  DUF4201       Domain of unknown function (DUF4201)


Domain annotation for each model (and alignments):
>> NT-C2  N-terminal C2 in EEIG1 and EHBP1 proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.4   4.6   1.2e-14   5.4e-11       6     137 ..      13     189 ..      10     193 .. 0.79
   2 ?   -2.3   0.7      0.74   3.3e+03      64      93 ..     351     380 ..     293     394 .. 0.62

  Alignments for each domain:
  == domain 1  score: 42.4 bits;  conditional E-value: 1.2e-14
       NT-C2   6 kflldlkihelsnipq.......ssgelyvkwrrkdskgts...ssgttekakvqngraewneelkipvtlflnkkgkkfeeKllelsvysvl...... 88 
                 kf ++++i+ l +           +   +++w+r+++++ +    +     ++  + ++ +n  +++  tl++n k+++ ++K+l++s+++v       
  EFC38964.1  13 KFAFNFSIDYLFVETMgnntvilDDNLYSIQWKRGRKRKGEtefVHPPPGSKHTTKIKVIYNRAFRFGGTLYKNEKKNEWQKKDLVISIEEVVagkdie 111
                 44444444444444444444888888889***999999777777555556667777789999************99999******************** PP

       NT-C2  89 ........................skskkk...kelGkvelnlaeyvned.eepttsrfllkks.kkvnsilslsiql 137
                                         +++k +   k+l+k++l+l+e+vne+ e++tt+++ll +  kk ns l++ ++l
  EFC38964.1 112 lakqynqylqqlqhekekgskkkeEPKKPNfevKTLAKHSLDLTEFVNETqETTTTRELLLTPEnKKFNSGLKILVKL 189
                 *****************9988755444444999*****************6777777777777755557777776654 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.74
       NT-C2  64 vtlflnkkgkkfeeKllelsvysvlskskk 93 
                 v+ + +k+ k +e+K+ e++ ++++++++k
  EFC38964.1 351 VQSKADKEIKAVEDKIKEIEKENEDHEKQK 380
                 222333555566666666666666655555 PP

>> DIL  DIL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.9         3   1.3e+04      63      72 ..     312     321 ..     278     353 .. 0.55
   2 !   27.7   0.2   5.8e-10   2.6e-06       2     101 ..     816     919 ..     815     922 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3
                 HHHHHHC-S- CS
         DIL  63 aaqllqlpks 72 
                  +++lq++++
  EFC38964.1 312 KLHFLQIENE 321
                 3455555555 PP

  == domain 2  score: 27.7 bits;  conditional E-value: 5.8e-10
                 HHHHHHHHHHHHHHHHHHHHS-SB-HHHHHHHHHHHHHHHHCCTS-.....-GGGGHHHH.....HHHHHHHC-S--HHHHHHHC.TT-TSS-HHHHHH CS
         DIL   2 lfsqlfyfinaelfNrlllrkklcsrskGlqlrrnlslledWaeeqgleeaaekhlapli.....qaaqllqlpkssledlesilrstcpaLnsaQlkr 95 
                 +f++l ++++a +fN+++  k+ +  + +l +++ l   e+W++++++ e +++  +++      +++++++l ++++ + es+ + +cp+Ln aQl +
  EFC38964.1 816 FFENLAKLSDALIFNHFIY-KEQIGAAIALPVKMGLVFTENWFNSKNITETTDQGTQSIAlhlsrEVSDVCILAQRQVLTDESMKNMVCPHLNKAQLTH 913
                 7999**************6.6668999*******************99644444444443555559**********9999999999************* PP

                 HHTTB- CS
         DIL  96 llenYr 101
                 +  n +
  EFC38964.1 914 IFANIH 919
                 *98865 PP

>> Tropomyosin  Tropomyosin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   2.0      0.38   1.7e+03       8      61 ..     114     167 ..     108     187 .. 0.74
   2 ?   -4.2   0.3       1.9   8.7e+03      66      84 ..     220     240 ..     202     245 .. 0.54
   3 !   19.5  56.4   1.1e-07    0.0005       4     215 ..     321     539 ..     319     549 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.38
  Tropomyosin   8 eeldeaeerlekakkkleeaekkaekaeaEvaalnrriqlleeelerteerlee 61 
                  ++ +++ ++l++ k+k  +++++ +k + Ev +l +    l e +++t+e  ++
   EFC38964.1 114 KQYNQYLQQLQHEKEKGSKKKEEPKKPNFEVKTLAKHSLDLTEFVNETQETTTT 167
                  566777777777788888888888888888888888877777777777777665 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 1.9
  Tropomyosin  66 Leeaekaades..erarKvlE 84 
                  L++ ek+ de+   +a K+ E
   EFC38964.1 220 LDDDEKSEDEDdlAEAEKTFE 240
                  333444444433333333333 PP

  == domain 3  score: 19.5 bits;  conditional E-value: 1.1e-07
  Tropomyosin   4 kqveeeldeaeerlekakkklee....aekkaekaeaEvaalnrriqlleeelerteerleealekLeeaekaadeserarKvlEnrelkdeekleel 97 
                  +q++++l++ +e++++a++kl e     +  + ka++E  a++ +i+ +e+e e  e++ e+  ekL+  + +   s   +K lE+   ++e+k+ el
   EFC38964.1 321 EQLKQNLETSQEAAQQAESKLFEiqlkMQMVQSKADKEIKAVEDKIKEIEKENEDHEKQKES--EKLKSTSSELTASLISIKNLESEVEEKEDKITEL 416
                  5899****************98721114456789******************9998876655..99****999999********************** PP

  Tropomyosin  98 eaqlke....akeiaeeadrkyeEvarklvvvesdLeraeeraeaaeskiveLeeeLkvvgnnlksLevseekaseredeyeeeirtLeekLkeaeeR 191
                  e+q+++    + ++ +e ++k++E ++++  ++++L + +++ +++++ki+eLee+ k  + +  +L    ek s+r d++e+++++Lee  k+a+e 
   EFC38964.1 417 ENQIRQlessSSNVGKESAEKINERNERILDLQNELSKLKSQKKKSDKKIEELEEQSKSLQDENVELTDLIEKCSKRMDDKEKQVKKLEESHKKAIES 514
                  ***987222245799*****************************************************************************999887 PP

  Tropomyosin 192 aee.AErsvqkLekevdrledelea 215
                   e+   ++   +e+ev+++  +l a
   EFC38964.1 515 VEQkCAQEKVLVEREVEKVKIDLLA 539
                  7652344444578888888887765 PP

>> DUF4201  Domain of unknown function (DUF4201)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   2.2     0.025   1.1e+02      67     107 ..     111     151 ..      93     183 .. 0.74
   2 !    3.7  24.7    0.0099        44      54     174 ..     309     426 ..     301     429 .. 0.89
   3 !   15.9  16.7   1.9e-06    0.0084      97     176 ..     435     516 ..     431     517 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.025
     DUF4201  67 rlkkkttktvhalthlkeklhmleselselkkelkekeerl 107
                 +l k++++ +++l+h+kek +  ++e ++ + e k++ ++ 
  EFC38964.1 111 ELAKQYNQYLQQLQHEKEKGSKKKEEPKKPNFEVKTLAKHS 151
                 567889999*********98877777666666555555544 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0099
     DUF4201  54 lnkkIeernkeLkrlkkkttktvhalthlkeklhmleselselkkelkekeerlaklrkelykvklerdklrkqneklkqqggllrvPaLlkDYdktke 152
                 +++k+   + e ++lk++  ++  a ++   kl +++ ++++ +++ ++  +  ++  ke++k +++++k +k+ eklk+ + +l +  +    ++ ++
  EFC38964.1 309 MQEKLHFLQIENEQLKQNLETSQEAAQQAESKLFEIQLKMQMVQSKADKEIKAVEDKIKEIEKENEDHEK-QKESEKLKSTSSELTASLI-S-IKNLES 404
                 56666666677789*******************************************************9.6788999999999777555.5.8***** PP

     DUF4201 153 kveekrksvkkLrrkvkilemr 174
                 +veek++++ +L+ ++++le++
  EFC38964.1 405 EVEEKEDKITELENQIRQLESS 426
                 *******************987 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 1.9e-06
     DUF4201  97 kkelkekeerlaklrkelykvklerdklrkqneklkqqggllrvPaL.lkD.YdktkekveekrksvkkLrrkvkilemrlk 176
                  ++++e++er+ +l+ el+k+k +++k +k+ e+l++q+  l+ + + l+D  +k+ ++ ++k+k+vkkL++++k++ ++++
  EFC38964.1 435 AEKINERNERILDLQNELSKLKSQKKKSDKKIEELEEQSKSLQDENVeLTDlIEKCSKRMDDKEKQVKKLEESHKKAIESVE 516
                 6899**************************************999875466256788999****************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3529  (0.196832); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                       248  (0.0138323); expected 17.9 (0.001)
Passed Fwd filter:                        90  (0.0050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 2.02u 0.41s 00:00:02.43 Elapsed: 00:00:00.63
# Mc/sec: 5633.67
//
Query:       EFC38965.1  [L=933]
Description: TPR domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.2e-24   83.7  14.1    1.3e-07   31.1   0.0    7.3  7  TPR_1       Tetratricopeptide repeat
    3.2e-22   76.8  10.5    8.6e-05   22.4   0.0    7.2  7  TPR_2       Tetratricopeptide repeat
    2.9e-13   49.2  11.4      0.056   13.8   0.0    6.7  6  TPR_17      Tetratricopeptide repeat
    5.6e-11   42.9   0.0      0.017   15.8   0.0    4.4  4  TPR_16      Tetratricopeptide repeat
      1e-10   41.8   8.7    0.00016   21.9   0.6    4.5  4  TPR_12      Tetratricopeptide repeat
      2e-10   40.7   0.1     0.0071   16.5   0.0    3.9  3  TPR_9       Tetratricopeptide repeat
      4e-08   33.4   4.1      0.041   14.5   0.0    5.6  6  TPR_6       Tetratricopeptide repeat
    1.2e-07   32.1   0.2      0.023   15.2   0.0    3.9  3  TPR_19      Tetratricopeptide repeat
    1.4e-07   31.2  12.6      0.061   13.6   0.0    6.3  5  TPR_8       Tetratricopeptide repeat
    2.3e-07   30.4   7.8     0.0019   17.8   0.3    5.3  5  TPR_11      TPR repeat
    3.6e-05   24.2   0.0        1.1   10.2   0.0    3.6  2  TPR_14      Tetratricopeptide repeat
    9.9e-05   22.5   9.9    0.00031   20.9   3.5    3.2  4  ANAPC3      Anaphase-promoting complex, cyclosome, subunit 3
    0.00023   20.9   3.1        1.9    8.7   0.0    5.0  5  TPR_7       Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.019   15.0   5.7        6.9    6.8   0.1    4.8  4  Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
        2.4    6.8  12.2        3.8    6.2  12.2    1.3  1  Presenilin  Presenilin
          3    7.8   4.7         59    3.7   0.0    4.1  4  TPR_10      Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.37   4.1e+02       4      21 ..     634     651 ..     632     655 .. 0.83
   2 !   31.1   0.0   1.1e-10   1.3e-07       3      34 .]     710     741 ..     708     741 .. 0.97
   3 !   16.6   0.8   4.5e-06     0.005       3      34 .]     744     775 ..     742     775 .. 0.96
   4 ?    4.2   0.0     0.036        40       5      24 ..     780     799 ..     779     804 .. 0.87
   5 !   12.4   0.0   9.7e-05      0.11       2      26 ..     811     835 ..     810     836 .. 0.94
   6 !   17.7   0.0   2.1e-06    0.0023       3      34 .]     847     878 ..     846     878 .. 0.96
   7 ?    2.9   0.2     0.096   1.1e+02       3      22 ..     881     900 ..     880     903 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.37
                 HHHHHHHHHHTT-HHHHH CS
       TPR_1   4 lynlGnayfklgkydeAl 21 
                 +  lG a+ +++ky   l
  EFC38965.1 634 YSFLGKALAEMKKYPLSL 651
                 7789**********8766 PP

  == domain 2  score: 31.1 bits;  conditional E-value: 1.1e-10
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 a++n+G ++ +l++ +eA+++ye  L+++P+n
  EFC38965.1 710 AHNNRGICLKRLKMNEEAIKAYEMSLRIDPSN 741
                 9*****************************98 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 4.5e-06
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 a++n+++ +++ ++++    yy+ A++l P++
  EFC38965.1 744 AYNNRAMYFYSDEEHENSMLYYKMAIRLKPTY 775
                 9*****************************97 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.036
                 HHHHHHHHHTT-HHHHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAleyy 24 
                  nlG+++ +l ky +A+e  
  EFC38965.1 780 TNLGLTLTQLTKYADAIELL 799
                 59***************976 PP

  == domain 5  score: 12.4 bits;  conditional E-value: 9.7e-05
                 HHHHHHHHHHHHTT-HHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyek 26 
                 +al  +G +y++  +++eAl++y+k
  EFC38965.1 811 NALITRGFCYMRRTDFEEALADYNK 835
                 68999******************98 PP

  == domain 6  score: 17.7 bits;  conditional E-value: 2.1e-06
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 +l+n++++y++  ++ eA+ y +k ++ nPn+
  EFC38965.1 847 TLFNMALCYYHTSRLREAIYYASKIISKNPND 878
                 689***************************97 PP

  == domain 7  score: 2.9 bits;  conditional E-value: 0.096
                 HHHHHHHHHHHTT-HHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAle 22 
                 a y +++ y k +k++e  e
  EFC38965.1 881 ARYYRALFYEKYEKFEESFE 900
                 88**************9765 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.1       1.1   1.2e+03       4      23 ..     634     653 ..     632     657 .. 0.82
   2 !   22.4   0.0   7.7e-08   8.6e-05       3      34 .]     710     741 ..     708     741 .. 0.96
   3 !    8.5   0.5    0.0021       2.4       2      34 .]     743     775 ..     742     775 .. 0.95
   4 !    7.5   0.0    0.0046       5.1       6      34 .]     781     809 ..     779     809 .. 0.92
   5 !   17.6   0.0   2.6e-06    0.0029       2      28 ..     811     837 ..     810     841 .. 0.92
   6 !   16.7   0.0   5.1e-06    0.0058       4      34 .]     848     878 ..     846     878 .. 0.96
   7 ?    3.0   0.4      0.13   1.4e+02       3      34 .]     881     912 ..     880     912 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 1.1
       TPR_2   4 lynlGlayyklgdyeeAlea 23 
                 +  lG+a++++++y   l +
  EFC38965.1 634 YSFLGKALAEMKKYPLSLYY 653
                 6789**********877766 PP

  == domain 2  score: 22.4 bits;  conditional E-value: 7.7e-08
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPnn 34 
                 a++n+G ++ +l+  eeA++a+e +l++dP n
  EFC38965.1 710 AHNNRGICLKRLKMNEEAIKAYEMSLRIDPSN 741
                 89****************************87 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0021
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPnn 34 
                  a++n+++  y   ++e    +++ A++l P++
  EFC38965.1 743 LAYNNRAMYFYSDEEHENSMLYYKMAIRLKPTY 775
                 59*****************************85 PP

  == domain 4  score: 7.5 bits;  conditional E-value: 0.0046
       TPR_2   6 nlGlayyklgdyeeAleafekAleldPnn 34 
                 nlGl + +l +y++A+e++  +le  P n
  EFC38965.1 781 NLGLTLTQLTKYADAIELLTIVLEWSPAN 809
                 89******************999999876 PP

  == domain 5  score: 17.6 bits;  conditional E-value: 2.6e-06
       TPR_2   2 ealynlGlayyklgdyeeAleafekAl 28 
                  al  +G +y+++ d+eeAl++++k +
  EFC38965.1 811 NALITRGFCYMRRTDFEEALADYNKLV 837
                 5899********************986 PP

  == domain 6  score: 16.7 bits;  conditional E-value: 5.1e-06
       TPR_2   4 lynlGlayyklgdyeeAleafekAleldPnn 34 
                 l+n++l+yy+  ++ eA+ +  k ++ +Pn+
  EFC38965.1 848 LFNMALCYYHTSRLREAIYYASKIISKNPND 878
                 8****************************97 PP

  == domain 7  score: 3.0 bits;  conditional E-value: 0.13
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPnn 34 
                 a y+++l y+k  ++ee  e+ +  l+l P n
  EFC38965.1 881 ARYYRALFYEKYEKFEESFEDVNIFLQLSPAN 912
                 679****************9999999999876 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0     5e-05     0.056       1      34 []     696     729 ..     696     729 .. 0.95
   2 !   13.3   0.1   7.5e-05     0.084       2      26 ..     731     755 ..     730     762 .. 0.85
   3 !    7.4   0.1    0.0056       6.2       1      34 []     764     797 ..     764     797 .. 0.94
   4 !    6.7   0.0    0.0097        11       6      33 ..     803     830 ..     800     831 .. 0.93
   5 ?    0.4   0.0      0.95   1.1e+03      16      33 ..     848     865 ..     846     866 .. 0.89
   6 !    8.9   0.1    0.0019       2.2       4      27 ..     870     893 ..     867     899 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 5e-05
      TPR_17   1 lylkaleldPnnadaynnLAelllknGdlmtArq 34 
                 ly++++ + + ++ a+nn++ +l++++  ++A++
  EFC38965.1 696 LYEQVISNFKGHSMAHNNRGICLKRLKMNEEAIK 729
                 7**************************9999985 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 7.5e-05
      TPR_17   2 ylkaleldPnnadaynnLAelllkn 26 
                 y+ +l++dP+n  aynn+A ++++ 
  EFC38965.1 731 YEMSLRIDPSNHLAYNNRAMYFYSD 755
                 999****************987754 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0056
      TPR_17   1 lylkaleldPnnadaynnLAelllknGdlmtArq 34 
                 +y+ a++l P++  + +nL+ +l ++ ++++A++
  EFC38965.1 764 YYKMAIRLKPTYQLPITNLGLTLTQLTKYADAIE 797
                 5999*************************99986 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0097
      TPR_17   6 leldPnnadaynnLAelllknGdlmtAr 33 
                 le  P n++a+  ++ ++ ++ d+++A+
  EFC38965.1 803 LEWSPANVNALITRGFCYMRRTDFEEAL 830
                 8899********************9997 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.95
      TPR_17  16 ynnLAelllknGdlmtAr 33 
                 ++n+A ++++  +l++A+
  EFC38965.1 848 LFNMALCYYHTSRLREAI 865
                 89********99999997 PP

  == domain 6  score: 8.9 bits;  conditional E-value: 0.0019
      TPR_17   4 kaleldPnnadaynnLAelllknG 27 
                 k + ++Pn+  a +++A +++k  
  EFC38965.1 870 KIISKNPNDDRARYYRALFYEKYE 893
                 7899****************9755 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   1.7e-05     0.019      14      67 ..     691     741 ..     690     742 .. 0.91
   2 !   11.0   0.0   0.00048      0.54      14      66 ..     725     774 ..     724     775 .. 0.96
   3 !   15.8   0.0   1.5e-05     0.017       3      60 ..     782     836 ..     780     846 .. 0.90
   4 ?    4.8   0.0     0.039        44      38      67 ..     849     878 ..     839     879 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.7e-05
      TPR_16  14 ddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapda 67 
                 d   +++e+++ ++     +  A++++g ++ r++  +eA+ +y+  lr +p++
  EFC38965.1 691 DVSNKLYEQVISNF---KGHSMAHNNRGICLKRLKMNEEAIKAYEMSLRIDPSN 741
                 556799********...77777*****************************986 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00048
      TPR_16  14 ddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapd 66 
                 ++A++a+e  l+ d   P ++ A+++++  ++   +++    +y+ a+r  p 
  EFC38965.1 725 EEAIKAYEMSLRID---PSNHLAYNNRAMYFYSDEEHENSMLYYKMAIRLKPT 774
                 79************...*******************************99885 PP

  == domain 3  score: 15.8 bits;  conditional E-value: 1.5e-05
      TPR_16   3 laraalragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraa 60 
                 l++ + ++ +y+dA+++l+++l+     P+++ Al  +g ++ r+ +++eA+a y+++
  EFC38965.1 782 LGLTLTQLTKYADAIELLTIVLEWS---PANVNALITRGFCYMRRTDFEEALADYNKL 836
                 677777889*********9999999...************************988876 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.039
      TPR_16  38 lllgdaalrqgrlaeAaalyraalraapda 67 
                 ++ ++++++ +rl eA+ +  + +   p++
  EFC38965.1 849 FNMALCYYHTSRLREAIYYASKIISKNPND 878
                 66799************9988887666665 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       5.9   6.6e+03      47      66 ..     633     652 ..     632     654 .. 0.69
   2 !   15.8   0.5   1.2e-05     0.013       5      75 ..     710     772 ..     706     774 .. 0.86
   3 ?    6.0   0.0     0.013        15       8      31 ..     781     804 ..     776     811 .. 0.74
   4 !   21.9   0.6   1.4e-07   0.00016       5      68 ..     812     868 ..     809     873 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 5.9
      TPR_12  47 tlrnLgrlyralgryeeAle 66 
                 ++  Lg ++ ++++y   l+
  EFC38965.1 633 SYSFLGKALAEMKKYPLSLY 652
                 56777888888877776665 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 1.2e-05
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaia 75 
                 a+nn++ +l rl+  +eA++ +e +l+i    +  +h l   +++n +++++  +++e    +++ a++++
  EFC38965.1 710 AHNNRGICLKRLKMNEEAIKAYEMSLRID---P-SNH-L---AYNNRAMYFYSDEEHENSMLYYKMAIRLK 772
                 6778*********************9999...3.456.4...799****9999999999999999999986 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.013
      TPR_12   8 nlaavlrrlgrydeAlellekale 31 
                 nl+++l++l +y++A+ell  +le
  EFC38965.1 781 NLGLTLTQLTKYADAIELLTIVLE 804
                 777777788888888777766665 PP

  == domain 4  score: 21.9 bits;  conditional E-value: 1.4e-07
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlell 68 
                 al  ++ +++r+ +++eAl+ ++k ++  ++       ++ +tl+n++ +y+ + r++eA+++ 
  EFC38965.1 812 ALITRGFCYMRRTDFEEALADYNKLVNELES-------EERSTLFNMALCYYHTSRLREAIYYA 868
                 66789********************555533.......3678*******************997 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0     0.007       7.8       9      41 ..     722     754 ..     716     774 .. 0.86
   2 !   16.5   0.0   6.3e-06    0.0071       7      57 ..     788     838 ..     782     853 .. 0.85
   3 !   12.8   0.0   8.7e-05     0.097       8      72 ..     858     922 ..     851     923 .. 0.87

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.007
       TPR_9   9 edweralavverllllaPddpeerrdRGlllaq 41 
                 + +e+a++++e+ l ++P  +  +  R++  + 
  EFC38965.1 722 KMNEEAIKAYEMSLRIDPSNHLAYNNRAMYFYS 754
                 66899*********************9987765 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 6.3e-06
       TPR_9   7 reedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeayla 57 
                 +  +++ a++ +  +l + P  +  +  RG++++++ ++++Alad +  + 
  EFC38965.1 788 QLTKYADAIELLTIVLEWSPANVNALITRGFCYMRRTDFEEALADYNKLVN 838
                 6667899999999********************************998774 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 8.7e-05
       TPR_9   8 eedweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaeairaqL 72 
                   +  +a+ ++  ++  +P+d + r+ R+l +++ + +++  +d + +l+l+p++ +   +r +L
  EFC38965.1 858 TSRLREAIYYASKIISKNPNDDRARYYRALFYEKYEKFEESFEDVNIFLQLSPANTAGTILRDRL 922
                 56777888899999999************************************988877777765 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       7.8   8.7e+03      21      30 ..     695     704 ..     692     706 .. 0.87
   2 ?    4.8   0.0     0.045        51       6      31 ..     714     739 ..     713     741 .. 0.84
   3 ?    1.6   0.0      0.48   5.4e+02       5      27 ..     781     803 ..     780     804 .. 0.86
   4 !    8.3   0.0    0.0035         4       6      29 ..     816     839 ..     811     839 .. 0.88
   5 !   14.5   0.0   3.6e-05     0.041       3      32 ..     848     877 ..     846     878 .. 0.95
   6 ?   -1.8   0.2         6   6.7e+03       2      16 ..     881     895 ..     880     900 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 7.8
                 HHHHHHHHH- CS
       TPR_6  21 ealerlikeY 30 
                 +++e++i+++
  EFC38965.1 695 KLYEQVISNF 704
                 68*****998 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.045
                 HHHHHHHHHHHHHHHHHHHHHHHH-T CS
       TPR_6   6 lalsyrklgdtdkAlealerlikeYP 31 
                 ++ ++++l+  ++A++a+e  ++  P
  EFC38965.1 714 RGICLKRLKMNEEAIKAYEMSLRIDP 739
                 799****99*********98666655 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.48
                 HHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealerli 27 
                 +l+l + +l+++++A+e+l  ++
  EFC38965.1 781 NLGLTLTQLTKYADAIELLTIVL 803
                 5889999999********98876 PP

  == domain 4  score: 8.3 bits;  conditional E-value: 0.0035
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAlealerlike 29 
                 ++ +y + +d ++Al+ +++l++e
  EFC38965.1 816 RGFCYMRRTDFEEALADYNKLVNE 839
                 799****88************986 PP

  == domain 5  score: 14.5 bits;  conditional E-value: 3.6e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   3 lyklalsyrklgdtdkAlealerlikeYPd 32 
                 l+++al+y+ + + ++A+ +  ++i++ P+
  EFC38965.1 848 LFNMALCYYHTSRLREAIYYASKIISKNPN 877
                 8*********88*****************9 PP

  == domain 6  score: -1.8 bits;  conditional E-value: 6
                 HHHHHHHHHHH.HHHH CS
       TPR_6   2 Alyklalsyrk.lgdt 16 
                 A y++al y+k   + 
  EFC38965.1 881 ARYYRALFYEKyE-KF 895
                 8999999999844.55 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.072        81      12      57 ..     695     740 ..     690     747 .. 0.89
   2 !   15.2   0.0   2.1e-05     0.023       6      48 ..     791     833 ..     786     854 .. 0.89
   3 !    8.3   0.1    0.0028       3.2       6      42 ..     860     896 ..     856     898 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.072
      TPR_19  12 alleqalqedpknaearllLAeallalgqldeAealLdalpeedpd 57 
                 +l+eq+++   +++ a  +  ++l  l+  +eA+++ +  ++ dp 
  EFC38965.1 695 KLYEQVISNFKGHSMAHNNRGICLKRLKMNEEAIKAYEMSLRIDPS 740
                 789999999999***********************99999988887 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 2.1e-05
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqldeAealL 48 
                 +ya+A++ll+ +l+ +p n +a++    +++   +++eA a  
  EFC38965.1 791 KYADAIELLTIVLEWSPANVNALITRGFCYMRRTDFEEALADY 833
                 79*************************************9755 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.0028
      TPR_19   6 dyaeAlalleqalqedpknaearllLAeallalgqld 42 
                 ++ eA+ + +++++++p++++ar++ A  + +   ++
  EFC38965.1 860 RLREAIYYASKIISKNPNDDRARYYRALFYEKYEKFE 896
                 6789********************9998887766666 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.0   5.4e-05     0.061       3      34 .]     710     741 ..     710     741 .. 0.93
   2 !    7.2   0.8    0.0059       6.7       3      33 ..     744     774 ..     743     775 .. 0.95
   3 ?    6.1   0.0     0.013        15       6      34 .]     781     809 ..     779     809 .. 0.94
   4 ?    5.8   0.0     0.017        19       3      28 ..     812     837 ..     810     838 .. 0.88
   5 ?    1.2   0.1      0.49   5.5e+02       3      33 ..     847     877 ..     846     878 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 5.4e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpdn 34 
                 a++n g +++ l+  eeA+++ye  l++dp+n
  EFC38965.1 710 AHNNRGICLKRLKMNEEAIKAYEMSLRIDPSN 741
                 5789999***********************86 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0059
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 ay+n ++   + +++e+++ yy+ a++l+p+
  EFC38965.1 744 AYNNRAMYFYSDEEHENSMLYYKMAIRLKPT 774
                 79***************************97 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.013
                 HHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   6 nlgsiylklgdyeeAkeyyekaleldpdn 34 
                 nlg+++ +l +y  A+e +  +le++p+n
  EFC38965.1 781 NLGLTLTQLTKYADAIELLTIVLEWSPAN 809
                 9***********************99986 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.017
                 HHHHHHHHHHHTT-HHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekal 28 
                 a+   g +y+   d+eeA + y+k +
  EFC38965.1 812 ALITRGFCYMRRTDFEEALADYNKLV 837
                 67788999***************976 PP

  == domain 5  score: 1.2 bits;  conditional E-value: 0.49
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpd 33 
                  ++n++++y  + ++ eA+ y  k ++ +p+
  EFC38965.1 847 TLFNMALCYYHTSRLREAIYYASKIISKNPN 877
                 589***************9998888876666 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.3   1.7e-06    0.0019      10      35 ..     724     749 ..     721     755 .. 0.92
   2 !    6.1   0.0    0.0076       8.6       4      38 ..     752     786 ..     751     789 .. 0.86
   3 ?    4.6   0.0     0.023        26       1      39 [.     783     821 ..     783     823 .. 0.89
   4 ?    3.7   0.2     0.044        50       9      21 ..     825     837 ..     820     858 .. 0.82
   5 ?    0.2   0.3      0.56   6.2e+02      21      40 ..     872     891 ..     855     891 .. 0.84

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.7e-06
      TPR_11  10 yeeAieaYkkAlkldPdnaeayynLG 35 
                 +eeAi+aY+  l++dP+n  ay+n++
  EFC38965.1 724 NEEAIKAYEMSLRIDPSNHLAYNNRA 749
                 69**********************97 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.0076
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlay 38 
                 +y+  + e+++  Yk A++l+P++     nLGl++
  EFC38965.1 752 FYSDEEHENSMLYYKMAIRLKPTYQLPITNLGLTL 786
                 5777788899999***********99999999986 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.023
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 G  ++++ ky +Aie +   l+ +P n++a+  +G+ y+
  EFC38965.1 783 GLTLTQLTKYADAIELLTIVLEWSPANVNALITRGFCYM 821
                 56678888**********************999998886 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.044
      TPR_11   9 kyeeAieaYkkAl 21 
                 ++eeA+++Y+k +
  EFC38965.1 825 DFEEALADYNKLV 837
                 89********976 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.56
      TPR_11  21 lkldPdnaeayynLGlayyk 40 
                 +  +P++ +a y ++l y k
  EFC38965.1 872 ISKNPNDDRARYYRALFYEK 891
                 6679**********988865 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.0     0.001       1.1       9      38 ..     716     745 ..     710     753 .. 0.87
   2 !    9.7   0.0    0.0015       1.7       8      42 ..     852     886 ..     846     914 .. 0.92

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.001
      TPR_14   9 eallalGdpdeAiallrralalaPddaeaw 38 
                   l +l   +eAi++++  l+ +P++  a+
  EFC38965.1 716 ICLKRLKMNEEAIKAYEMSLRIDPSNHLAY 745
                 56789999******************9987 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0015
      TPR_14   8 aeallalGdpdeAiallrralalaPddaeawllla 42 
                 a  +++  +++eAi ++ ++++++P+d++a+++ a
  EFC38965.1 852 ALCYYHTSRLREAIYYASKIISKNPNDDRARYYRA 886
                 566888999**********************9876 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       3.3   3.7e+03      63      80 ..     715     732 ..     657     734 .. 0.74
   2 ?    3.1   0.3       0.1   1.1e+02      28      79 ..     744     799 ..     721     802 .. 0.70
   3 !    7.5   0.1    0.0042       4.7       4      54 ..     791     842 ..     788     849 .. 0.87
   4 !   20.9   3.5   2.8e-07   0.00031       4      74 ..     825     897 ..     822     900 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 3.3
                 HHHHHHTT-HHHHHHHH- CS
      ANAPC3  63 AqcllkLkkyeeAiaaLe 80 
                 + cl  Lk  eeAi+a+e
  EFC38965.1 715 GICLKRLKMNEEAIKAYE 732
                 557778899999999876 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.1
                 HH...HHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHHH CS
      ANAPC3  28 ll...AlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaaL 79 
                 ++   A  +y++++++  + +++ a +l+++ +     ++ +l +L ky +Ai +L
  EFC38965.1 744 AYnnrAMYFYSDEEHENSMLYYKMAiRLKPTYQLPITNLGLTLTQLTKYADAIELL 799
                 333347777888888888888888888888888888888999***********988 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0042
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclylngqykrAyellrka.klnsk 54 
                 +y +Ai l+  +l+ ++ + +++   + c+ ++ ++++A+  ++k+ ++ ++
  EFC38965.1 791 KYADAIELLTIVLEWSPANVNALITRGFCYMRRTDFEEALADYNKLvNELES 842
                 799**********9999999999999***************99999666554 PP

  == domain 4  score: 20.9 bits;  conditional E-value: 2.8e-07
                 -HHHHHHHHHHHH..HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHH CS
      ANAPC3   4 nyknAiflaerlla.aetespedayllAlclylngqykrAyellrka.klnskslgcrylfAqcllkLkkyee 74 
                 ++++A+  +++l++  e+e  + ++  Alc+y++++  +A+++++k   +n+++ ++ry  A  + k++k+ee
  EFC38965.1 825 DFEEALADYNKLVNeLESEERSTLFNMALCYYHTSRLREAIYYASKIiSKNPNDDRARYYRALFYEKYEKFEE 897
                 567888888999932555555556666*******************************************999 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0098        11       1      30 [.     710     739 ..     710     743 .. 0.86
   2 ?   -0.5   0.0       1.5   1.7e+03       1      31 [.     744     772 ..     744     774 .. 0.81
   3 !    8.7   0.0    0.0017       1.9       3      31 ..     780     806 ..     779     811 .. 0.84
   4 ?    0.3   0.1      0.81     9e+02       9      28 ..     820     840 ..     818     846 .. 0.76
   5 ?   -0.5   0.1       1.5   1.7e+03       1      19 [.     847     865 ..     847     867 .. 0.92

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0098
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLaltk 30 
                 a++n + +  rl   eeAi+ ye sL+++ 
  EFC38965.1 710 AHNNRGICLKRLKMNEEAIKAYEMSLRIDP 739
                 67899999999999**********888775 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.5
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLaltkd 31 
                 a++n a  + ++ ++e+   +y+   a++  
  EFC38965.1 744 AYNNRAMYFYSDEEHENSMLYYKM--AIRLK 772
                 68888888889999*********9..76655 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0017
       TPR_7   3 lnLarlysrlGdyeeAielyeqsLaltkd 31 
                  nL+ +  +l +y++Aiel++   +l+ +
  EFC38965.1 780 TNLGLTLTQLTKYADAIELLTI--VLEWS 806
                 69******************99..66555 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.81
       TPR_7   9 ysrlGdyeeAielyeqsL.al 28 
                 y r+ d+eeA+  y ++  +l
  EFC38965.1 820 YMRRTDFEEALADYNKLVnEL 840
                 89999*****99887755555 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 1.5
       TPR_7   1 aLlnLarlysrlGdyeeAi 19 
                 +L+n+a +y    + +eAi
  EFC38965.1 847 TLFNMALCYYHTSRLREAI 865
                 799******9999999998 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.1      0.24   2.6e+02      13      35 ..     720     742 ..     716     746 .. 0.86
   2 ?    2.1   0.0      0.19   2.1e+02      11      37 ..     786     812 ..     781     814 .. 0.86
   3 ?    3.3   0.3     0.076        85       1      36 [.     845     880 ..     845     882 .. 0.90
   4 ?    6.8   0.1    0.0062       6.9       4      41 ..     882     919 ..     879     931 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.24
                 HHT-HHHHHHHHHHHHHHTTS-H CS
  Fis1_TPR_C  13 klgeYseArryvdalLeiEPenr 35 
                 +l+  +eA +  ++ L+i+P+n+
  EFC38965.1 720 RLKMNEEAIKAYEMSLRIDPSNH 742
                 5666689999************8 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.19
                 HHHHT-HHHHHHHHHHHHHHTTS-HHH CS
  Fis1_TPR_C  11 hyklgeYseArryvdalLeiEPenrQa 37 
                  + l +Y +A +++  +Le  P n +a
  EFC38965.1 786 LTQLTKYADAIELLTIVLEWSPANVNA 812
                 567999******************877 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.076
                 HHHHHHHHHHHHHHT-HHHHHHHHHHHHHHTTS-HH CS
  Fis1_TPR_C   1 reclYylAlGhyklgeYseArryvdalLeiEPenrQ 36 
                 r  l+  Al +y   + +eA  y+  ++++ P+   
  EFC38965.1 845 RSTLFNMALCYYHTSRLREAIYYASKIISKNPNDDR 880
                 5679****************************9865 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0062
                 HHHHHHHHHHHT-HHHHHHHHHHHHHHTTS-HHHHHHH CS
  Fis1_TPR_C   4 lYylAlGhyklgeYseArryvdalLeiEPenrQaqsLk 41 
                  Yy Al + k  +++e+ + v+ +L++ P n     L+
  EFC38965.1 882 RYYRALFYEKYEKFEESFEDVNIFLQLSPANTAGTILR 919
                 6******************************8666555 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2  12.2    0.0034       3.8     199     294 ..      65     184 ..      62     290 .. 0.54

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0034
  Presenilin 199 Lvelaqerneei..fpaLiYsatvvvlaaeek.kaevaeseeeeeaekkkeeasesskeeeseeesseksaqsse........................ 270
                 L+e a++ +++i  +   i++ t v +++  + +++ +e+ee+e+++++++ ++++++ee+++++  e      +                        
  EFC38965.1  65 LLEHAESNEKQIrkIEEFIFEFTRVESEEDGSsSSSSSEEEEDEDSDNERNDDDRDHSEERRDHSDDE------Dviteeqisnvmqeikndikkeqdn 157
                 66667666666622356888888887754333322222222222222222222222222222222222......0222233555666666655444333 PP

  Presenilin 271 ........seeeseeesseaessaeesseeke 294
                         +     ++s+++++++++s+++++
  EFC38965.1 158 rtlnhhhhH-----QASASSSQEPSSSNSTNS 184
                 322211110.....111111111111111111 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       9.9   1.1e+04      24      33 ..     723     732 ..     721     736 .. 0.72
   2 ?    1.5   0.5      0.26   2.9e+02       4      30 ..     744     770 ..     743     772 .. 0.92
   3 ?    3.7   0.0     0.053        59       6      25 ..     780     799 ..     779     800 .. 0.92
   4 ?    0.5   0.0      0.55   6.1e+02      23      37 ..     824     838 ..     822     839 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 9.9
      TPR_10  24 lleealairr 33 
                 + eea+ +++
  EFC38965.1 723 MNEEAIKAYE 732
                 5688998887 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.26
      TPR_10   4 slnNLanalrqrgrydeAealleeala 30 
                 ++nN a++ ++  +++ ++ +++ a++
  EFC38965.1 744 AYNNRAMYFYSDEEHENSMLYYKMAIR 770
                 79******************9999987 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.053
      TPR_10   6 nNLanalrqrgrydeAeall 25 
                 +NL+ +l+q+ +y++A +ll
  EFC38965.1 780 TNLGLTLTQLTKYADAIELL 799
                 7***************9986 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.55
      TPR_10  23 alleealairrrllG 37 
                  ++eeala + +l++
  EFC38965.1 824 TDFEEALADYNKLVN 838
                 6899***99999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (933 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1954  (0.108985); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                       110  (0.00613531); expected 17.9 (0.001)
Passed Fwd filter:                        40  (0.00223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 1.22u 0.36s 00:00:01.58 Elapsed: 00:00:00.59
# Mc/sec: 4757.09
//
Query:       EFC38966.1  [L=675]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0001   22.6   0.1    0.00026   21.3   0.1    1.7  1  VWD       von Willebrand factor type D domain
  ------ inclusion threshold ------
      0.059   13.6   0.2        0.1   12.8   0.2    1.3  1  DUF4979   Domain of unknown function (DUF4979)
        2.3    8.6  14.1       0.27   11.6   1.7    3.3  2  DUF2383   Domain of unknown function (DUF2383)


Domain annotation for each model (and alignments):
>> VWD  von Willebrand factor type D domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.1   4.3e-08   0.00026       1      81 [.      42     119 ..      42     173 .. 0.62

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 4.3e-08
         VWD   1 CsvsgdphitTFDgakytfpgnctYvvlaqdcseqpdefsvnvtvkkedagqenvsclksvkvrvg.....dveieltrrn.kkvlv 81 
                 C + gdph++TF+g k++f g+ +Yv  aq+++ +     ++++++++++++ +v    +v v+++     ++ +  ++ + +kv +
  EFC38966.1  42 CQALGDPHYKTFNG-KFDFYGVGDYV-FAQTNDGN-----LIIHTRTGKWNKASV--NTAVAVKLEgsrifEYDVVSDKFFlNKVPT 119
                 9999********99.7**********.99997777.....899999999998877..566666666225445555555444433322 PP

>> DUF4979  Domain of unknown function (DUF4979)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.2   1.8e-05       0.1      74     133 ..      69     128 ..      50     138 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 1.8e-05
     DUF4979  74 ekakgnitlDtnlGsyksgaNkatilkgkegsevyyyDLslenaalgesavklttssate 133
                 +++ gn+ + t++G +++++ ++ +  + egs ++ yD+ +++ +l++ ++k++ +++++
  EFC38966.1  69 QTNDGNLIIHTRTGKWNKASVNTAVAVKLEGSRIFEYDVVSDKFFLNKVPTKINVGETVS 128
                 5899************99988888888999******************998887776665 PP

>> DUF2383  Domain of unknown function (DUF2383)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   1.7   4.5e-05      0.27      31      83 ..     312     364 ..     304     370 .. 0.93
   2 ?    3.9   1.3     0.011        65      33      70 ..     466     502 ..     454     513 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.5e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHCT------------------------- CS
     DUF2383  31 qlktlleriaeereeaaeeLqseiralggepedggslagklhrawvdlksalt 83 
                 +lk+ll++ +++ ++a+++L+ ++r+l+++p++ ++ + k++ra  +lk +l 
  EFC38966.1 312 KLKKLLKKKSRAAKKAVRKLKRKLRKLKRKPKKVSTKTKKAKRASRKLKRKLR 364
                 79******************************************999998775 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.011
                 HHHHHHHHHHHHHHHHHHHHHHHHCT------------ CS
     DUF2383  33 ktlleriaeereeaaeeLqseiralggepedggslagk 70 
                 k  ++r a++ ++aa++L+ ++r+l +  ++  s++++
  EFC38966.1 466 K-KAKRAARKARRAARKLKRKLRRLARRLKKAKSFKAA 502
                 4.46788899999******************9999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (675 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4682  (0.261141); expected 358.6 (0.02)
Passed bias filter:                      991  (0.0552736); expected 358.6 (0.02)
Passed Vit filter:                       381  (0.0212505); expected 17.9 (0.001)
Passed Fwd filter:                       123  (0.00686039); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 2.33u 0.43s 00:00:02.76 Elapsed: 00:00:00.66
# Mc/sec: 3087.75
//
Query:       EFC38967.1  [L=634]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.8e-36  124.0   4.6    2.4e-30  105.9   0.0    3.3  4  AAA_2            AAA domain (Cdc48 subfamily)
    2.2e-13   50.7   0.0    3.9e-06   27.3   0.0    3.0  2  AAA              ATPase family associated with various cellul
    6.4e-06   26.2   2.4    0.00021   21.3   0.0    4.0  4  AAA_5            AAA domain (dynein-related subfamily)
    0.00031   20.2   0.2     0.0038   16.6   0.0    2.5  2  Mg_chelatase     Magnesium chelatase, subunit ChlI
     0.0016   17.6   0.2       0.07   12.2   0.0    2.6  2  MCM              MCM P-loop domain
      0.004   16.5   0.0     0.0089   15.3   0.0    1.5  1  Zeta_toxin       Zeta toxin
      0.004   17.2   0.0      0.018   15.1   0.0    2.2  1  ClpB_D2-small    C-terminal, D2-small domain, of ClpB protein
     0.0094   16.2   0.0      0.053   13.8   0.0    2.4  2  AAA_22           AAA domain
  ------ inclusion threshold ------
      0.025   14.3   0.0      0.085   12.6   0.0    2.0  2  PduV-EutP        Ethanolamine utilisation - propanediol utili
      0.027   15.0   0.1       0.19   12.3   0.0    2.4  2  AAA_18           AAA domain
      0.042   14.2   0.0       0.19   12.1   0.0    2.1  2  AAA_16           AAA ATPase domain
      0.056   13.6   0.0       0.24   11.6   0.0    2.1  2  AAA_33           AAA domain
      0.063   13.5   0.0       0.14   12.3   0.0    1.6  1  AAA_28           AAA domain
      0.063   13.0   0.0       0.46   10.2   0.0    2.2  2  Sigma54_activat  Sigma-54 interaction domain
      0.077   13.5   0.0      0.077   13.5   0.0    2.3  1  ABC_tran         ABC transporter
        1.9    8.1   9.7         16    5.1   9.6    2.2  1  Hydrolase_3      haloacid dehalogenase-like hydrolase


Domain annotation for each model (and alignments):
>> AAA_2  AAA domain (Cdc48 subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       4.1   4.5e+03     124     155 ..      16      65 ..      14      74 .. 0.50
   2 ?   -2.6   0.6       4.6   5.1e+03     132     155 ..     104     129 ..      98     144 .. 0.44
   3 !   18.2   0.0   1.9e-06    0.0021       5      50 ..     220     265 ..     218     278 .. 0.85
   4 !  105.9   0.0   2.1e-33   2.4e-30      30     170 ..     423     542 ..     401     543 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 4.1
                 EEEE--TTHHHHTTTS-S..................TTTTSGGG--HHHH CS
       AAA_2 124 Imtgafgsskisdesrsk..................eeeeekkkeeveee 155
                 I++ga++ss +  ++  k                  + +++kkk++ ++e
  EFC38967.1  16 IASGAIASSSKHATQIVKylaqqqlasvnssyhqssRVSTSKKKDNDDDE 65 
                 66666666666664444455555666655555554433333334444444 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 4.6
                 HHHHTTTS-S..TTTTSGGG--HHHH CS
       AAA_2 132 skisdesrsk..eeeeekkkeeveee 155
                 s  s++s s+  ++e+++++++  ++
  EFC38967.1 104 SGASNSSSSSskKSEQQTTENDEANK 129
                 33333333321122233333333333 PP

  == domain 3  score: 18.2 bits;  conditional E-value: 1.9e-06
                 -EEEE--TTSSHHHHHHHHHHHTT-....-EEEEEGGG---....----T CS
       AAA_2   5 silllgptgvGktelakalaellfvkkekkliradaselle....eeeve 50 
                 +il++g+tg+Gkte+a+ la+l ++    ++  ++a++++e    + +v+
  EFC38967.1 220 NILMIGSTGCGKTEIARRLAKLVSA----PFLKVEATKYTElgyhGRDVD 265
                 89*********************96....***********9666555554 PP

  == domain 4  score: 105.9 bits;  conditional E-value: 2.1e-33
                 ....-EEEEEGGG-------THHHHHHHHHTTT-HHHHTTSEEEEETGGG----...---------HHHHHHHHHHHH--EE-------EE-TT-EEEE CS
       AAA_2  30 kkekkliradaselleeeevehlvsrligappgyvgaeegGivllDEidKihpk...essgadvSregVqrdLLqileggtltdkqgrkvdtknilfIm 125
                  k+ ++++++a+  l e e+++ +++ +  +++ + ae +Giv++DEidKi+ +   +  + d S+egVqrdLL++leg+t+++k+g +v+t+++lfI+
  EFC38967.1 423 YKKVEMTIKEAKVRLVELEMDKFLNSPLFIEEARKIAESDGIVFIDEIDKICGSpekKAVQGDASGEGVQRDLLPLLEGCTINTKYG-PVKTDHVLFIA 520
                 47899********9999***********************************9998888999*************************.*********** PP

                 EE--TTHHHHTTTS-STTTTSGGG--HHHHHHTT--HHHHTT--E CS
       AAA_2 126 tgafgsskisdesrskeeeeekkkeeveeelkkglipEllgRlpe 170
                 +gaf+++k+sd                       l  E++gRlp+
  EFC38967.1 521 SGAFHQQKPSD-----------------------LMSEFQGRLPV 542
                 ***********.......................99999999987 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   6.6e-07   0.00074       1      36 [.     221     256 ..     221     294 .. 0.79
   2 !   27.3   0.0   3.5e-09   3.9e-06      18     128 ..     429     540 ..     424     547 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 6.6e-07
                 EEEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSS CS
         AAA   1 vllyGppGtGKTllakavakelgvefleisgsells 36 
                 +l++G  G+GKT +a+ +ak ++++fl++++++ ++
  EFC38967.1 221 ILMIGSTGCGKTEIARRLAKLVSAPFLKVEATKYTE 256
                 699****************************99983 PP

  == domain 2  score: 27.3 bits;  conditional E-value: 3.5e-09
                 HHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH...TTCCCHHHHHHHHHHHHHHHHTTTS.......SSTEEEE CS
         AAA  18 vakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksr...sgseseeeervvnqLlteldgvkkk.......eskvivi 106
                  +ke++v+++e+++ ++l     +s+  i+e  k a++     i+fiDEid++++s      + + ++e v+  Ll+ l+g + +       +++v++i
  EFC38967.1 429 TIKEAKVRLVELEMDKFL-----NSPLFIEEARKIAES---DGIVFIDEIDKICGSPekkAVQGDASGEGVQRDLLPLLEGCTINtkygpvkTDHVLFI 519
                 567788888888888888.....445555554444443...38*************98754557788999***************9*****9666**** PP

                 EEESSGGGSTHHHHSTTSSEEE CS
         AAA 107 gatnrpdkldpallrgRfdrki 128
                 + +   ++ ++ l+ + f+ ++
  EFC38967.1 520 ASGAFHQQKPSDLM-SEFQGRL 540
                 99998777777777.5555443 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.0   1.9e-07   0.00021       1      37 [.     220     256 ..     220     257 .. 0.94
   2 ?   -1.3   0.0       1.8     2e+03      85     108 ..     317     340 ..     308     357 .. 0.81
   3 ?    0.6   0.1      0.45   5.1e+02      62      77 ..     458     473 ..     447     476 .. 0.81
   4 ?   -1.4   0.0       1.9   2.1e+03      70      85 ..     617     632 ..     616     633 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 1.9e-07
                 EEEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT-- CS
       AAA_5   1 dvlLvGppGtgKselaerlaaalnreveyvqltrdtt 37 
                 ++l++G +G+gK+e+a+rla+++ ++++ v  t++t+
  EFC38967.1 220 NILMIGSTGCGKTEIARRLAKLVSAPFLKVEATKYTE 256
                 689**************************99999885 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.8
                 HHHHHHSSEEE..-SSSEEE---. CS
       AAA_5  85 Llslleerrllleeggelvkaknd 108
                 L++l+e r ++l+ g++ +   ++
  EFC38967.1 317 LQQLIEYRIIHLMIGTKNIANLRN 340
                 899*********999988866555 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.45
                 ---G-SEEEEESGGG- CS
       AAA_5  62 aaregeilvlDEvera 77 
                  a++  i+++DE++++
  EFC38967.1 458 IAESDGIVFIDEIDKI 473
                 456889********96 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 1.9
                 EEESGGG--HHHHHHH CS
       AAA_5  70 vlDEveraesevlnsL 85 
                 v+DE+ r+ +e+ ++L
  EFC38967.1 617 VIDEIRRCAKETGKEL 632
                 79*******9997766 PP

>> Mg_chelatase  Magnesium chelatase, subunit ChlI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.32   3.6e+02       4      19 ..     176     191 ..     174     212 .. 0.84
   2 !   16.6   0.0   3.4e-06    0.0038      23      48 ..     219     244 ..     204     258 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.32
  Mg_chelatase   4 dvkGqeeakraleiaa 19 
                   +++Gq++ak+a+ +a 
    EFC38967.1 176 HIVGQKDAKKAVSVAL 191
                   799***********97 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 3.4e-06
  Mg_chelatase  23 HnlllvGppGsGKtmlakrlpsllpp 48 
                    n+l++G+ G+GKt +a+rl++l+++
    EFC38967.1 219 KNILMIGSTGCGKTEIARRLAKLVSA 244
                   59*******************99864 PP

>> MCM  MCM P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   6.2e-05      0.07      13      82 ..     164     243 ..     154     264 .. 0.71
   2 ?    2.4   0.0     0.062        70     119     133 ..     459     473 ..     440     482 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.2e-05
                 THHHHHHHHSSTTSSS-HHHHHHHHHHHH---EBBB.....SSSSB..BCSS-...EEEEEESSTSTHHHHHHHHHHHSS CS
         MCM  13 diieklvksiapsiyghedvkkaillqlfggvkkkl.....edktk..lrgdi...nvllvgdpgtaKsqlLkyveklap 82 
                  + +++v+++ ++i+g++d kka+ ++l   +++k      +++++    ++i   n+l++g  g++K+++ ++++kl++
  EFC38967.1 164 LTPQEIVNCLDKHIVGQKDAKKAVSVALRNRYRRKIlidwaKSEKTllDPSEIipkNILMIGSTGCGKTEIARRLAKLVS 243
                 456899**********************99888643121111222222123334559**************999997764 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.062
                 HTTTSEEEEESGGGS CS
         MCM 119 ladkGvcciDefdkm 133
                     G++ iDe+dk+
  EFC38967.1 459 AESDGIVFIDEIDKI 473
                 5568**********7 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   7.9e-06    0.0089      11      52 ..     213     252 ..     203     278 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 7.9e-06
  Zeta_toxin  11 psqerPklillgGqpGAGKselaellkdelerqgnvvrldpD 52 
                 ps+  Pk il+ G++G+GK+e+a+ l++ +     +++++++
  EFC38967.1 213 PSEIIPKNILMIGSTGCGKTEIARRLAKLV--SAPFLKVEAT 252
                 45577*******************998876..5555555555 PP

>> ClpB_D2-small  C-terminal, D2-small domain, of ClpB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   1.6e-05     0.018       3      61 ..     552     619 ..     551     621 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.6e-05
                    HHHHHHHHHH...HHHHHHHHSCT.TTEEEEEHHHHHHHHHH.....HTSBTTTBTCCHHHHHHHHTH CS
  ClpB_D2-small   3 keelkkIvdl...alkklekrlke.rgvelevtdealdalae.....kgydpeyGARpLrriiqreie 61 
                     eel +++++    l +++  l++ +g++l ++d+a + +a+     ++ + + GAR L  ii++ i 
     EFC38967.1 552 PEELYQVLTMpefNLVRQNISLMNsEGISLVFSDAANREIANfsalcNAGNDNLGARRLIGIIEKVID 619
                    588999999998888899999987799************9983333345899*************985 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   4.7e-05     0.053       8      51 ..     221     255 ..     218     331 .. 0.82
   2 ?   -2.5   0.0       5.2   5.8e+03      92     103 ..     462     473 ..     444     481 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.7e-05
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaeeerpevvfvtlpsst 51 
                 ++ +G +G+GKT  +rrl++           ++++++v++++ t
  EFC38967.1 221 ILMIGSTGCGKTEIARRLAKLV---------SAPFLKVEATKYT 255
                 7889****************99.........8899988888877 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 5.2
      AAA_22  92 ielliiDEaqhl 103
                  +++ iDE++++
  EFC38967.1 462 DGIVFIDEIDKI 473
                 478999999987 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   7.6e-05     0.085       2      23 ..     219     240 ..     218     266 .. 0.77
   2 ?   -3.8   0.0       8.6   9.6e+03      89      99 ..     607     617 ..     589     620 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 7.6e-05
   PduV-EutP   2 kkilliGkvgsGKttLtqalkg 23 
                 k+il+iG++g+GKt ++++l +
  EFC38967.1 219 KNILMIGSTGCGKTEIARRLAK 240
                 79***************99987 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 8.6
   PduV-EutP  89 nkeviGiitki 99 
                 ++ +iGii k+
  EFC38967.1 607 ARRLIGIIEKV 617
                 68899999886 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       2.2   2.5e+03      27      68 ..      43      81 ..      25     101 .. 0.49
   2 ?   12.3   0.0   0.00017      0.19       1      25 [.     221     258 ..     221     307 .. 0.67

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 2.2
      AAA_18 27 nlrdvakenglllevdpealdeskrldedkldklldaleens 68
                + +++++ ++ +++  ++   + + + ++++++++ al ++ 
  EFC38967.1 43 VNSSYHQSSRVSTSKKKD---NDDDEFKKNMNNIFGALGGSE 81
                334444444444444444...444444444455555555543 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 0.00017
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf.............g 25 
                 Il  G  G+GKt++a++L+k+                g
  EFC38967.1 221 ILMIGSTGCGKTEIARRLAKLVSApflkveatkytelG 258
                 778899*************9952244444433334442 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       3.7   4.1e+03     107     127 ..      73      95 ..      20     159 .. 0.55
   2 ?   12.1   0.0   0.00017      0.19      24      83 ..     218     273 ..     207     332 .. 0.67

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 3.7
      AAA_16 107 avpelagaea..srllellkrll 127
                 + ++l g+e    +l++ ++++l
  EFC38967.1  73 IFGALGGSEQvkGHLNDIFNAFL 95 
                 33333333334433444444333 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 0.00017
      AAA_16  24 pelvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysa.laqalareellr 83 
                 p ++l +G  G+GK+ ++r+l++ +++    fl+ +++++ +++ y    ++++ar +l+ 
  EFC38967.1 218 PKNILMIGSTGCGKTEIARRLAKLVSAP---FLKVEATKY-TELGYHGrDVDTIAR-DLVD 273
                 4899******************999888...777777777.333443334444433.4443 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00021      0.24       2      23 ..     221     242 ..     221     297 .. 0.77
   2 ?   -2.8   0.0       5.6   6.3e+03      58      93 ..     566     602 ..     543     619 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00021
      AAA_33   2 vllvGlpGsGKstlaerllkkl 23 
                 +l++G  G+GK+  a+rl+k  
  EFC38967.1 221 ILMIGSTGCGKTEIARRLAKLV 242
                 69****************9654 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 5.6
      AAA_33  58 ilnelarkalsagrnvil.datnlsrrerarflklar 93 
                  +++ +  + s+g+++++ da n++ +++++++++ +
  EFC38967.1 566 LVRQNISLMNSEGISLVFsDAANREIANFSALCNAGN 602
                 4555566677788887777888888888877777655 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   0.00013      0.14       2      64 ..     221     283 ..     220     293 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00013
      AAA_28   2 ivitGgestGKTtlleaLaar.gypvvpEaareileeklakgedalpwvedllafaervleeql 64 
                 i ++G  ++GKT ++++La+    p ++  a++++e ++  +  +  + +dl+++ + vl++ +
  EFC38967.1 221 ILMIGSTGCGKTEIARRLAKLvSAPFLKVEATKYTELGYHGRDVDTIA-RDLVDVSINVLRNNI 283
                 899****************98778888777788887776554443333.677777777776665 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   0.00041      0.46      22      61 ..     218     254 ..     204     257 .. 0.80
   2 ?   -0.6   0.0      0.83   9.3e+02      93     105 ..     461     473 ..     456     480 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00041
                      SS-EEEECSTTSSHHHHHHHHHHHSTTTTS-EEEEETTTS CS
  Sigma54_activat  22 dlsvlitGesGtGKellaraiheaskrkekpfvavncaai 61 
                      + ++l+ G +G+GK+ +ar + +  +   +pf++v+ +++
       EFC38967.1 218 PKNILMIGSTGCGKTEIARRLAKLVS---APFLKVEATKY 254
                      5799***************9987654...67777776655 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.83
                      TTSEEEEETGGGS CS
  Sigma54_activat  93 dgGtlfLDeigel 105
                      ++G++f+Dei ++
       EFC38967.1 461 SDGIVFIDEIDKI 473
                      589*******986 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   6.8e-05     0.077      14     106 ..     221     364 ..     218     378 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 6.8e-05
                 EEEEESTTSSHHHHHHHHTTSS--........SEEEEEETTCEGGG.......B-HHHCCHCEEEE-SS.--S-TTSBHHHH................. CS
                 xxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxx.xxxxxxxxxxxx................. RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkp........teGeilldgkdlke.......qeleslrkeigvlpqe.pqlfpeltvren................. 79 
                 + ++G++G+GK+ +++ la+l++         +  e+ + g+d+++        ++++lr++i  l+++  +  p +t  e+                 
  EFC38967.1 221 ILMIGSTGCGKTEIARRLAKLVSApflkveatKYTELGYHGRDVDTiardlvdVSINVLRNNITDLFKQfLNRPPSSTPSEQeegtleepdlfgsylqq 319
                 6799******************99566554443334466666666633333334555555555555544344444444444488888888888888888 PP

                 ..................HHHTCHHHHHHHSTTGGTTCBGESTTS CS
                 ..................xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  80 ..................esdeeiekalsklglkelkdtvvkssp 106
                                    ++  i+++l+ l++ el+d++++ s+
  EFC38967.1 320 lieyriihlmigtknianLRNGTIKDYLNMLRNGELDDRKIEVSM 364
                 887777777777766655445558888888888888888876655 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   9.6     0.014        16      83     165 ..      86     168 ..      16     190 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.014
                  HHHHHHHHHHHTTCEEEEEESSEEEESTT.THHHHHHHHHCHCTCEEEESHHHHHCHCSESEEEEES-HHHHHHHHHHHHHHC CS
  Hydrolase_3  83 dvkeiikllkennveillytedkvyvlnkeksekkkkeeektkkkkeeidseeeledeeiakililkdkekldelekelkskl 165
                  ++++i++++ + + +i+ +++++  +++++kse++++e+++ +k k++  ++ee+ +e+++ki++ + + + +++e++l+++ 
   EFC38967.1  86 HLNDIFNAFLKPGANIHTSGASNSSSSSSKKSEQQTTENDEANKPKNTFIQDEERLNENFHKIVFEAYHMQRKQFENKLTPQE 168
                  6789999999999999999999999999999*********************************************9999874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (634 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1455  (0.0811534); expected 358.6 (0.02)
Passed bias filter:                      686  (0.038262); expected 358.6 (0.02)
Passed Vit filter:                       100  (0.00557756); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.86u 0.36s 00:00:01.22 Elapsed: 00:00:00.54
# Mc/sec: 3524.46
//
Query:       EFC38968.1  [L=525]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.2e-07   31.2   5.5    4.2e-07   30.3   5.5    1.5  1  RGS             Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.065   12.9   0.5       0.18   11.5   0.2    1.9  2  Sirohm_synth_C  Sirohaem biosynthesis protein C-terminal


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   5.5   4.7e-11   4.2e-07       2     115 ..      52     209 ..      51     212 .. 0.96

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 4.7e-11
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS....................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHH CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka....................keqeelkkkakeIyneylapsspkelnidkklreelekrl 80 
                 +e++++++  r lF e+l+ + s e l F  +vee++++                    ++  e+ +ka+ I+++++ ++ + eln+  + ++++++  
  EFC38968.1  52 FEEMMDSKETRDLFYEYLQLNRSVESLMFMNQVEEYRAEynkkfenvicgenvdkkqvhTKIVEIYSKARGILDQFVFQGGQFELNLAFANKDKIRELW 150
                 78999999************************************************9999999999********************************9 PP

                 CSS........................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHH CS
         RGS  81 eke........................qpsrklfeeaqeevfellekdsypkFlksely 115
                 e++                         ++ +lf  a  +v   l+ d++p+F +se+ 
  EFC38968.1 151 ETKvcesfekldkerleveklskiismLETDTLFGLAMFSVNLDLRFDQFPRFSRSEML 209
                 99999**********************9****************************985 PP

>> Sirohm_synth_C  Sirohaem biosynthesis protein C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.2     2e-05      0.18      29      66 ..     145     182 ..     137     183 .. 0.87
   2 ?   -3.1   0.0      0.72   6.4e+03      37      58 ..     275     296 ..     274     297 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 2e-05
  Sirohm_synth_C  29 pkRMkWmskvcdswsleelaeldeedmekLlemyekgk 66 
                     + R  W +kvc+s++  + ++l++e+++k+++m e+++
      EFC38968.1 145 KIRELWETKVCESFEKLDKERLEVEKLSKIISMLETDT 182
                     45778**************************9998875 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.72
  Sirohm_synth_C  37 kvcdswsleelaeldeedmekL 58 
                     + c+ ++ +    +d+e+++ L
      EFC38968.1 275 NTCELYQSKTSYVFDTETLKGL 296
                     7899999999988888888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (525 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1137  (0.0634168); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.28s 00:00:00.94 Elapsed: 00:00:00.45
# Mc/sec: 3476.25
//
Query:       EFC38969.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       754  (0.0420548); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1543.73
//
Query:       EFC38970.1  [L=2282]
Description: basal body protein NBP-2 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-47  161.4  17.6      3e-47  161.4  17.6    2.9  3  REJ       REJ domain
    2.1e-20   72.7 313.8     0.0001   22.6   8.8   21.4 19  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.1   0.00033         3     105     182 ..    1493    1571 ..    1479    1579 .. 0.71
   2 !  161.4  17.6   3.4e-51     3e-47      92     430 ..    1577    1926 ..    1575    1935 .. 0.91
   3 ?   -4.2   1.2      0.58   5.2e+03     277     319 ..    2129    2171 ..    2004    2201 .. 0.65

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.00033
         REJ  105 GseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpeals.........gtllssstssltfpaselvanl.tynftltvs 182 
                  + +S   d+     + l+++W+c++      +++d++ ln+  +  +         +  +s  t++++fp+ +   +  ty+ftl  s
  EFC38970.1 1493 AFDSVSLDR-----RPLTFSWTCTAGP----SSDDQTKLNSLISSTTlsgtsvkflIGTTSLITPVISFPTCYTGTGAtTYTFTLDGS 1571
                  555555554.....469******7777....5555555554444443446678777777788889999******99999*****9865 PP

  == domain 2  score: 161.4 bits;  conditional E-value: 3.4e-51
         REJ   92 srvigyrgnltLdGseSyDpdeddhsqsqlsYeWlcrrsq...................pmngrnndnpllnidpeals.................. 151 
                  s +++ ++nl + Gs+  +++++  +     Y++++++s+                   ++ ++  d++++++dp+a+s                  
  EFC38970.1 1577 SLSVSTKNNLLVLGSSFTNINQEG-D-----YYFIVTASAdsaqavsttvkvsavaqpiSVAFSVPDMTQSKDDPVAFSisvtdpsntqdtltlstt 1667
                  667888999999999988887774.4.....*****99999******************************************************** PP

         REJ  152 ....gtllssstssltfpaselvanltynftltvskrsrksasteqtilvvd.gepplvsiecisncngkvnpndrlvllas.clncakdlkdvtfe 242 
                           s+ +s ++++s++ a+ ty ft+t++k+sr ++s++ ti+v d ++  +v+++++sn++ ++ + ++  +l++ +l+    l+  tf+
  EFC38970.1 1668 cidsTGTSCSNPGSASSFSSSFAAG-TYIFTTTATKGSR-TSSAKLTITVLDtSKSLIVRVSITSNVDLTTVDPTKDLYLTYnTLDS---LSAPTFS 1759
                  **9966777788899999*******.8************.8889999888652677899*********9999999988888856655...99***** PP

         REJ  243 WslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsvtPlegvaletaftvrC.qgw 338 
                  W                ts + + ++++ L i +++L +g+sy ++l  ++ +g+ksg+as++++vn+pPt G ++v+P++gval+++f+++C +gw
  EFC38970.1 1760 W----------------TSATGDVSSSSLLIIPSSNLVPGSSYVVSL--SVVDGAKSGTASVTITVNSPPTVGVFEVYPTSGVALSDSFSLKCgNGW 1838
                  *................788888888889******************..999********************************************* PP

         REJ  339 tDkdqPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarvsvsltitVkppavnnstieellenrtrne 430 
                  +D+++PL++++ +++++ s +++ l+e+s+++s  + LP++ +  ++++t++++VyD +ga+++  ++it+++p++++   ++l  + ++++
  EFC38970.1 1839 SDPQTPLSFQF-FFYDSVSMKWNSLTEKSQQQSANIQLPSPSS--GSTLTIKAVVYDALGASSESRTNITITQPSNADV-ASTLTSMAKGTN 1926
                  ***********.*****************************99..9*****************************9998.555555555544 PP

  == domain 3  score: -4.2 bits;  conditional E-value: 0.58
         REJ  277 nkLqsgesyaltlrvtdkegkksglasisfkvnepPtgGtcsv 319 
                   ++ + +s  +t+++t+++ +  ++  ++f++  + ++ t+sv
  EFC38970.1 2129 TAFANAKSVSVTVKTTSTSVTNAVTNAMTFSFADGTSSATISV 2171
                  4455555555555444444444455555555555555555555 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.8   8.4    0.0041        37       6      23 ..      44      61 ..      40      66 .. 0.77
   2 !   10.3  11.0   7.8e-05       0.7       5      32 .]     231     258 ..     227     258 .. 0.89
   3 ?    2.2   8.2     0.026   2.4e+02       5      23 ..     271     288 ..     268     302 .. 0.83
   4 !   17.7   9.3   3.8e-07    0.0034       6      32 .]     309     335 ..     304     335 .. 0.92
   5 !    5.2   6.7    0.0032        28       1      24 [.     342     363 ..     342     368 .. 0.84
   6 !    8.8   9.1   0.00024       2.1       6      32 .]     520     545 ..     517     545 .. 0.91
   7 !   13.4  10.0   8.6e-06     0.077       5      32 .]     559     584 ..     555     584 .. 0.88
   8 !   18.5   7.5   2.1e-07    0.0019       6      32 .]     600     625 ..     596     625 .. 0.88
   9 !    3.9  10.3    0.0077        69       1      32 []     702     732 ..     702     732 .. 0.83
  10 !   16.8  14.6   7.5e-07    0.0067       5      32 .]     881     906 ..     877     906 .. 0.93
  11 !   14.5   8.5   3.9e-06     0.035       6      32 .]    1070    1095 ..    1064    1095 .. 0.93
  12 !   21.1   9.7   3.4e-08   0.00031       5      32 .]    1108    1134 ..    1100    1134 .. 0.89
  13 ?   -5.4  15.0         2   1.8e+04       8      27 ..    1149    1167 ..    1143    1185 .. 0.79
  14 !   22.6   8.8   1.1e-08    0.0001       5      32 .]    1198    1224 ..    1194    1224 .. 0.91
  15 ?   -3.3  16.1       1.4   1.2e+04       4      28 ..    1236    1261 ..    1233    1279 .. 0.86
  16 !   13.8  12.1   6.1e-06     0.055       1      32 []    1284    1313 ..    1284    1313 .. 0.89
  17 ?   -1.8   0.3      0.48   4.3e+03      22      32 .]    1315    1325 ..    1315    1325 .. 0.92
  18 !   12.0   8.7   2.4e-05      0.22       1      27 [.    1329    1353 ..    1329    1357 .. 0.85
  19 ?   -1.7   0.4      0.45   4.1e+03      22      32 .]    1363    1373 ..    1363    1373 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0041
       EGF_2  6 eiCgghGtCvnqcGq.CdC 23
                + C+g+G C  ++G  C+C
  EFC38970.1 44 DSCNGRGFCS-TTGDsCQC 61
                56*******8.46755*** PP

  == domain 2  score: 10.3 bits;  conditional E-value: 7.8e-05
       EGF_2   5 deiCgghGtC.vnqcGqCdC..dsgyqGktC 32 
                  + C+g G+C    +G C C   ++++G +C
  EFC38970.1 231 ANVCSGKGKCgS--TG-CTCnnTTQWTGSDC 258
                 578*******66..99.***9899******* PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.026
       EGF_2   5 deiCgghGtCvnqcGqCdC 23 
                  + C+g+G+C ++   C+C
  EFC38970.1 271 ANVCKGRGSCAAPD-SCSC 288
                 578********999.7*** PP

  == domain 4  score: 17.7 bits;  conditional E-value: 3.8e-07
       EGF_2   6 eiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 + C+g G+C++q   C+C +++y+Gk+C
  EFC38970.1 309 SVCNGFGQCISQD-TCQCtNPNYSGKNC 335
                 57********999.9************* PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.0032
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCd 24 
                 C++  + C+  G C n++  CdC+
  EFC38970.1 342 CQDV-NSCNSKGFCANST-LCDCS 363
                 8876.78*******9899.9***6 PP

  == domain 6  score: 8.8 bits;  conditional E-value: 0.00024
       EGF_2   6 eiCgghGtCvnqcGq.CdCdsgyqGktC 32 
                 + C+ +G+Cv   G  CdC+ g+ G +C
  EFC38970.1 520 NVCSRRGSCV--MGSyCDCKHGFGGTNC 545
                 57********..8877***********9 PP

  == domain 7  score: 13.4 bits;  conditional E-value: 8.6e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+ghG C  + G C C + y+G +C
  EFC38970.1 559 NLTCSGHGNCT-FQG-CTCTAPYYGSNC 584
                 899*******8.688.************ PP

  == domain 8  score: 18.5 bits;  conditional E-value: 2.1e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ +G+Cv+ +  C+C++g++G  C
  EFC38970.1 600 STCSANGKCVEDN-TCVCNNGFSGSMC 625
                 68*******9666.9*********999 PP

  == domain 9  score: 3.9 bits;  conditional E-value: 0.0077
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdC....dsgyqGktC 32 
                 C+  + +C+  G+C    G+C C    d  y+G+tC
  EFC38970.1 702 CK--NITCQ-YGICS--AGKCICsystDYFYYGPTC 732
                 88..56998.9****..9*****997555566***9 PP

  == domain 10  score: 16.8 bits;  conditional E-value: 7.5e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +C+g+G+C   +G C C sgy+G++C
  EFC38970.1 881 GVTCSGRGSCS--NGTCNCASGYTGANC 906
                 679********..*************** PP

  == domain 11  score: 14.5 bits;  conditional E-value: 3.9e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g G+C++q   C C +gy+G +C
  EFC38970.1 1070 TVCSGKGSCISQD-TCNCANGYSGSNC 1095
                  57********999.9************ PP

  == domain 12  score: 21.1 bits;  conditional E-value: 3.4e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+Cv+++  C C++gy+G +C
  EFC38970.1 1108 SSVCSGRGSCVAPN-SCTCKTGYTGEKC 1134
                  789********999.7************ PP

  == domain 13  score: -5.4 bits;  conditional E-value: 2
       EGF_2    8 CgghGtCvnqcGqCdCdsgy 27  
                  C+ +G+C+++   C C+ ++
  EFC38970.1 1149 CSFRGSCNTTD-SCICNGNF 1167
                  9999***9666.69998776 PP

  == domain 14  score: 22.6 bits;  conditional E-value: 1.1e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ Cgg+G+C++++  C+C+sgy+G  C
  EFC38970.1 1198 STVCGGQGSCISPN-TCKCKSGYSGTAC 1224
                  578********999.9***********9 PP

  == domain 15  score: -3.3 bits;  conditional E-value: 1.4
       EGF_2    4 sdeiCgg..hGtCvnqcGqCdCdsgyq 28  
                  +++ Cgg  +G+C+ +  +C+C +++ 
  EFC38970.1 1236 DSNVCGGstRGSCIGPD-NCKCVTNWN 1261
                  4789**********888.8***99997 PP

  == domain 16  score: 13.8 bits;  conditional E-value: 6.1e-06
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Csa  ++C+ hGtC++   +C+C  ++ G++C
  EFC38970.1 1284 CSA-TDTCNSHGTCDSNF-KCVCTGNFIGDYC 1313
                  888.589*******9444.8************ PP

  == domain 17  score: -1.8 bits;  conditional E-value: 0.48
       EGF_2   22 dCdsgyqGktC 32  
                  +C +g+ G++C
  EFC38970.1 1315 SCATGFVGANC 1325
                  599******** PP

  == domain 18  score: 12.0 bits;  conditional E-value: 2.4e-05
       EGF_2    1 CsasdeiCgghGtC.vnqcGqCdCdsgy 27  
                  Csa   +C+ hG+C +  +G C C+ ++
  EFC38970.1 1329 CSA-AKTCNSHGSCtN--TGSCTCNGNF 1353
                  888.589*******55..789***9887 PP

  == domain 19  score: -1.7 bits;  conditional E-value: 0.45
       EGF_2   22 dCdsgyqGktC 32  
                  +C +g+ G+ C
  EFC38970.1 1363 KCLNGFLGDGC 1373
                  699*******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2282 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1241  (0.0692175); expected 358.6 (0.02)
Passed bias filter:                      252  (0.0140554); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.26u 0.35s 00:00:01.61 Elapsed: 00:00:00.57
# Mc/sec: 12024.27
//
Query:       EFC38971.1  [L=639]
Description: Hypothetical protein NAEGRDRAFT_81458 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.027   15.1   5.0       0.43   11.2   1.7    2.5  2  Com_YlbF  Control of competence regulator ComK, YlbF/YmcA
       0.59   10.1   7.4        5.9    6.9   0.3    4.6  4  TPR_1     Tetratricopeptide repeat
        3.2    7.9   6.4         10    6.3   2.1    2.4  2  RRP7      Ribosomal RNA-processing protein 7 (RRP7) C-termina
        4.5    7.5   6.7         28    4.9   0.8    2.8  2  DUF3896   Protein of unknown function (DUF3896)


Domain annotation for each model (and alignments):
>> Com_YlbF  Control of competence regulator ComK, YlbF/YmcA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   1.7   9.7e-05      0.43      55      97 ..      63     113 ..      42     115 .. 0.66
   2 ?    4.4   0.1     0.012        56      30      54 ..     583     607 ..     578     637 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 9.7e-05
                 T.......----HHHHHHHH.HHHHHHHTSHHHHHHHHHHHHHHHHHHHHH CS
    Com_YlbF  55 g.......eelkeeekkelq.elkeeldknplvkeyleaeqelnellqevn 97 
                 g       ++lk++++++ +  +++e ++n+l+k+y+e e+++++l + + 
  EFC38971.1  63 GrnyhatsKMLKKAKQQAPEtTVYSEQEQNELIKNYIELEDKFKKLTENII 113
                 323333445555555543334677777*******************99885 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.012
                 CSHHHHHHHHHHHHHHHHHHHHHHT CS
    Com_YlbF  30 edeelqklikefkklqkelqekqmk 54 
                 + +el++ +kef++l++++q+ + +
  EFC38971.1 583 SKDELRQVLKEFEQLKESIQDLKLT 607
                 5789999**********99997765 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.3       1.2   5.2e+03      16      27 ..     282     293 ..     281     294 .. 0.87
   2 ?   -0.9   0.0      0.38   1.7e+03      19      34 .]     355     370 ..     349     370 .. 0.79
   3 ?    3.6   0.0     0.014        63      15      29 ..     396     410 ..     393     411 .. 0.91
   4 ?    6.9   0.3    0.0013       5.9       3      25 ..     497     519 ..     495     521 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.2
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 +y+ A  +y  A
  EFC38971.1 282 DYEAAKLAYTTA 293
                 89***9999877 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.38
                 HHHHHHHHHHHHSTTH CS
       TPR_1  19 eAleyyekALelnPnn 34 
                 +  +  +++++ +Pnn
  EFC38971.1 355 QSMDVLDECIKTDPNN 370
                 55666789*******8 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.014
                 T-HHHHHHHHHHHHH CS
       TPR_1  15 gkydeAleyyekALe 29 
                 ++y  A+ + e AL 
  EFC38971.1 396 NNYSNAIHHLEMALA 410
                 79***********95 PP

  == domain 4  score: 6.9 bits;  conditional E-value: 0.0013
                 HHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyye 25 
                  +  +G++y+   +y+  + +y+
  EFC38971.1 497 FYMIKGACYYDCDMYELSINAYS 519
                 57889****************96 PP

>> RRP7  Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   2.1    0.0023        10      60     112 ..      65     117 ..      45     120 .. 0.84
   2 ?    3.2   0.1     0.021        92      89     111 ..     583     605 ..     581     610 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0023
        RRP7  60 aeekakkkekkkkkkkelldFYrFQirekkkeelaeLrkkFeeDkekieelke 112
                 + +++ k+ kk k+++ +   Y+ Q +++  ++  eL  kF++ +e+i e+++
  EFC38971.1  65 NYHATSKMLKKAKQQAPETTVYSEQEQNELIKNYIELEDKFKKLTENIIEYRR 117
                 4556778888999999999************************9999988876 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.021
        RRP7  89 kkeelaeLrkkFeeDkekieelk 111
                  k+el + +k Fe+ ke+i++lk
  EFC38971.1 583 SKDELRQVLKEFEQLKESIQDLK 605
                 58999****************99 PP

>> DUF3896  Protein of unknown function (DUF3896)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.8    0.0063        28       6      22 ..      65      81 ..      61     110 .. 0.80
   2 ?    4.6   0.6    0.0079        35      18      45 ..     577     604 ..     570     622 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0063
     DUF3896  6 dynatkkyleekkqqlC 22
                +y+at k l + kqq  
  EFC38971.1 65 NYHATSKMLKKAKQQAP 81
                7*************964 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.0079
     DUF3896  18 kqqlCkklssltlskkereqlkleidny 45 
                 k  lC+  ++l    ke eqlk  i + 
  EFC38971.1 577 KDYLCRSKDELRQVLKEFEQLKESIQDL 604
                 7889******************999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (639 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1217  (0.0678789); expected 358.6 (0.02)
Passed bias filter:                      707  (0.0394333); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.48
# Mc/sec: 3991.98
//
Query:       EFC38972.1  [L=683]
Description: hypothetical protein NAEGRDRAFT_73295 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-06   28.5   4.7    2.9e-06   27.6   4.7    1.6  1  RGS            Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.052   12.4   0.4      0.083   11.7   0.4    1.2  1  C12orf66_like  KICSTOR complex C12orf66 like


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   4.7   3.2e-10   2.9e-06       6      88 ..     557     637 ..     552     673 .. 0.83

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 3.2e-10
                 HTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTT CS
         RGS   6 ledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrk 88 
                 l + +++++++e++e+efs+en +F+++ + ++++  +   +k+ ++I  e++ + s+ e+ni+++++++  + l+k q+  +
  EFC38972.1 557 LTNTDLLQILKEYCEKEFSSENYEFYIKLKSLQNR--KFIKLKELQKIEAEFIRNYSKYEVNIPSSCKKTFYELLNKCQEETQ 637
                 678899****************************9..6667889**************************9999999754443 PP

>> C12orf66_like  KICSTOR complex C12orf66 like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.4   9.2e-06     0.083     119     221 ..     560     664 ..     529     680 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 9.2e-06
                    ---S----THHHHHH..HHHHHHHHHHHGGGSSS--HHHHHHHHSTTTGGG-----------HHHHHHHHHHHHHHHHHHHHHHTTT-HHHHH.HH CS
  C12orf66_like 119 ahlseqllsfvqarl..elldfyeklaslgsskvvnseelvvaldallkkyskrfhhPilsrlessfqvevdvltqllraqaqisewkflPsl.ln 211
                    ++l + l ++ +  +  e  +fy kl sl+ +k+++ +el+   ++ +++ysk +   i s  +++f   ++  ++  +   q+   +  P l ln
     EFC38972.1 560 TDLLQILKEYCEKEFssENYEFYIKLKSLQNRKFIKLKELQKIEAEFIRNYSK-YEVNIPSSCKKTFYELLNKCQEETQLEFQLIWDCVAPELlLN 654
                    234444444444433227789*****************************985.88999999***9999999999999999999888888875268 PP

                    HHHHHHHHHH CS
  C12orf66_like 212 lheahsklqs 221
                    l ++ s+lq 
     EFC38972.1 655 LQDTFSRLQD 664
                    9999999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (683 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1049  (0.0585086); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.25s 00:00:00.86 Elapsed: 00:00:00.42
# Mc/sec: 4881.58
//
Query:       EFC38973.1  [L=311]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1004  (0.0559987); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1862.27
//
Query:       EFC38974.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      4e-07   29.6   1.1    5.1e-07   29.3   1.1    1.2  1  Form_Nir_trans  Formate/nitrite transporter
  ------ inclusion threshold ------
        2.1    7.0  14.7        2.7    6.7  14.7    1.0  1  EIF4E-T         Nucleocytoplasmic shuttling protein for mRNA 
        2.2    7.6   9.1        3.4    7.0   9.1    1.3  1  TMEM43          Transmembrane protein 43


Domain annotation for each model (and alignments):
>> Form_Nir_trans  Formate/nitrite transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.3   1.1   8.6e-11   5.1e-07       2      68 ..     138     207 ..     137     211 .] 0.90

  Alignments for each domain:
  == domain 1  score: 29.3 bits;  conditional E-value: 8.6e-11
                     HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHCCT....TCHHHHHHHHHCCCHHHHH CS
  Form_Nir_trans   2 ivekvvaagvkkaklsldklfllgilAGafigfgvllalvvaaalaes....npglakllgglvFpvGlil 68 
                     +++k+  +g +k kl++d++++l+++AG+f g+g++++l++a++ +       pgl+k+++g +F + li+
      EFC38974.1 138 VMDKMKMEGIRKSKLTFDQMIILSLFAGIFKGVGCTMSLLTAGNSE-LlekqIPGLQKFFFGGMFLINLII 207
                     67999************************************99853.36888889**********998876 PP

>> EIF4E-T  Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7  14.7   0.00045       2.7     514     654 ..      18     143 ..       2     146 .. 0.59

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.00045
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXX......XXXX CS
     EIF4E-T 514 qeqqakslgvqtpnilvqkrveiqnliqeivrgdisleflekelsnpstlahtkdviaavlrelsngrrnslspvpdqnvlsqqelqqaaleplaqpqe 612
                  +qq++     ++n  +  + + ++++  i   di+l+ l+  ++ +   + t  ++++++ +  n +  +++       +++q+++q++    ++  +
  EFC38974.1  18 ITQQQEYNYHTSSNTIHSMNNH-KHIHHDITPIDIPLDDLN--INTTTISTTTSTSPNEIIDNNNNNNNITIN------TINHQQQKQQQATT-TIIIH 106
                 3333333333333434444433.788888876666666555..565566666779999999998888877777......44444444443333.33334 PP

                 XXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXX CS
     EIF4E-T 613 qalseelftqndsnrniqqhir.hsnSptPlaFTPTSVlRKmt 654
                  +++++  +q+      q+ i+ ++    Pl  TPT V+ Km 
  EFC38974.1 107 HHYHHYDKKQE------QEPIKsNVTTYPPLYLTPTMVMDKMK 143
                 55555444444......3333326777789************6 PP

>> TMEM43  Transmembrane protein 43
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   9.1   0.00056       3.4      16     120 ..      14     116 ..       6     137 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00056
      TMEM43  16 sggseetettYtYekeWrselidSseFkepegh.eNpssmpvesetqvaedvkvGaykLskelvekinaeeeltldsqsaqeiatskeqknvklhggyi 113
                   ++ +++++Y Y++  +s+ i S ++++   h   p ++p+++ +   ++++  + + ++e++++ n+++++t ++ + q+++++++ +++ +h++y 
  EFC38974.1  14 HPSEITQQQEYNYHT--SSNTIHSMNNHKHIHHdITPIDIPLDDLNINTTTISTTTSTSPNEIIDNNNNNNNITINTINHQQQKQQQATTTIIIHHHYH 110
                 556788999******..69*********8888844458999999999999999999999******************9999999555555555555444 PP

      TMEM43 114 Yfgkspq 120
                 ++ k +q
  EFC38974.1 111 HYDK-KQ 116
                 4433.33 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2550  (0.142228); expected 358.6 (0.02)
Passed bias filter:                      654  (0.0364772); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1238.00
//
Query:       EFC38975.1  [L=585]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.8e-25   88.8   0.0    3.9e-25   88.3   0.0    1.1  1  Ald_Xan_dh_C2  Molybdopterin-binding domain of aldehyde dehyd
    5.7e-21   74.9   0.0      1e-20   74.1   0.0    1.4  1  Ald_Xan_dh_C   Aldehyde oxidase and xanthine dehydrogenase, a
    1.7e-20   73.4   0.0    1.2e-19   70.7   0.0    2.1  2  FAD_binding_5  FAD binding domain in molybdopterin dehydrogen
    4.9e-18   65.2   0.0    1.2e-17   63.9   0.0    1.6  1  CO_deh_flav_C  CO dehydrogenase flavoprotein C-terminal domai
      4e-08   33.2   0.0    7.8e-08   32.2   0.0    1.5  1  Fer2_2         [2Fe-2S] binding domain
  ------ inclusion threshold ------
       0.32   10.7   5.7        2.6    7.8   0.3    3.4  3  DUF3481        C-terminal domain of neuropilin glycoprotein


Domain annotation for each model (and alignments):
>> Ald_Xan_dh_C2  Molybdopterin-binding domain of aldehyde dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.3   0.0   1.3e-28   3.9e-25      26     123 ..     471     574 ..     447     581 .. 0.88

  Alignments for each domain:
  == domain 1  score: 88.3 bits;  conditional E-value: 1.3e-28
                    S.EEEEEEEEEEBE---SS--EEEEEEET....CTTEEEEEES-SSHHHHHHHHHHHHT--GGGEEEE-.SB-S--TTTT.SS--HHHHHHHHHHH CS
  Ald_Xan_dh_C2  26 dhvvegefrtgrqehfylEtqaalavpdd....edgeltvysstqaphevrrlvaevlglpenkvrviv.prvGGGFGgK.tqsvplevlaalaAk 115
                       +eg++++g+qehfylEtq++l++p+     e+   t+ysstq ++ +++lv+++l+l++n+++v++ +++GGGFGgK t++  l++++a+ A+
     EFC38975.1 471 YEYIEGDCYIGGQEHFYLETQSCLVIPESnnfiEKSGWTIYSSTQSISTTQQLVSKALNLSMNQIQVKTpQKIGGGFGGKeTRASVLACACAIGAL 566
                    3469***********************65333346789*******************************778************************ PP

                    HHTS-EEE CS
  Ald_Xan_dh_C2 116 ktgrpVkl 123
                    k ++ V+l
     EFC38975.1 567 KSQQTVRL 574
                    ******98 PP

>> Ald_Xan_dh_C  Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.1   0.0   3.4e-24     1e-20       2     108 ..     317     421 ..     316     423 .. 0.94

  Alignments for each domain:
  == domain 1  score: 74.1 bits;  conditional E-value: 3.4e-24
                   T-SCCGGGCC-TTTE.EEEEEE-SSSSEEEEEEE-HHHHCSTTEEEEEEHHHHCCGTECCTTSSS-EEEESS-SSEESSTT-EEEEEEESSHHHHHH CS
  Ald_Xan_dh_C   2 GeavYvdDipapgal.ylafvrStkahAkivsidvsaalalpGVvavitakdlpkenkaigsiledeedallaedkvrsvgqavaavvAedeetArk 97 
                   G+ +Y+dDip+ +++  ++ +  t++ Aki +id s+al+++GV  ++ +kd+p++n  i  i+++ee  ++ + + +s gq +++++A++ ++Ar+
    EFC38975.1 317 GKSQYLDDIPHLENElQAYPIFTTQPYAKIIEIDESKALEMEGVKYFVNYKDVPNNNIGIV-IPNEEE--VFKSSESTSCGQLIGLILANTLNQARE 410
                   999************99999***********************************988884.666654..*************************** PP

                   HHHT-EEEEEE CS
  Ald_Xan_dh_C  98 AaklvkveYee 108
                   A k+v ++Y++
    EFC38975.1 411 ASKKVIIKYQP 421
                   *********96 PP

>> FAD_binding_5  FAD binding domain in molybdopterin dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.7   0.0     4e-23   1.2e-19      92     170 ..      71     151 ..      38     152 .. 0.85
   2 ?   -0.3   0.0      0.26   7.6e+02      45      62 ..     288     305 ..     278     312 .. 0.80

  Alignments for each domain:
  == domain 1  score: 70.7 bits;  conditional E-value: 4e-23
                    HHHHTSS-HHHHHH-BHHHHHHHT-TT-SSHHHHHHTTEEEEEEESSE..EEEEECHHHEEETTEESS-TT-EEEEEEEE- CS
  FAD_binding_5  92 ealekiAspqiRnvaTiGGNlataspisDlapaLlaldAevelrsaeg..erevpleeflkgpgktalepgelitaveiPa 170
                    ++++++As+ iRnva+iGGN++t+spisDl+p++  l+A+++l + +    r++ +++++ g++k  + p e++++v+iP+
     EFC38975.1  71 YQCKWFASTPIRNVASIGGNIMTGSPISDLVPIWQSLNAKLNLLNIKTneIRNISIRDLYIGYRKLNILPTEILLNVIIPN 151
                    899****************************************76555459*****************************6 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.26
                    SEEEEGTTSGGGS-EEEE CS
  FAD_binding_5  45 ehliditgipelkeieet 62 
                    +++id++ ++el++i ++
     EFC38975.1 288 SNIIDLNLVKELNTIGKN 305
                    789***********9876 PP

>> CO_deh_flav_C  CO dehydrogenase flavoprotein C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.9   0.0     4e-21   1.2e-17       1      93 [.     161     257 ..     161     258 .. 0.94

  Alignments for each domain:
  == domain 1  score: 63.9 bits;  conditional E-value: 4e-21
                    EEEEEESSSSSS-ESEEEEEEEEEETTCEECEEEEEEESSSSS-EE-HHHHHHHTTSBSSH...HHHHHHHHHHHTTCHHHTC.TTC-HHHHHHHH CS
  CO_deh_flav_C   1 sayklsrrrendiaivnaAfrveleedgkiedariafggvaptpvraekaeaaLiGkplse...elleeaakaleeelspasd.prasaeYRrsla 92 
                    +a+k+s+r+e+diaivn ++ ++l+++++ied++i fgg++  ++    + ++LiGk++ e    +le+ +k+l e+l+++++ p+++  YR++l 
     EFC38975.1 161 KAFKQSKRKEDDIAIVNSCMTIKLNNNNIIEDCSISFGGMSFMVIYLNYLNEYLIGKNFIEnynLILENSIKLLNEKLNLNENtPGGQSLYRMTLS 256
                    59********************************************************988443479**************************997 PP

                    H CS
  CO_deh_flav_C  93 v 93 
                    +
     EFC38975.1 257 Q 257
                    5 PP

>> Fer2_2  [2Fe-2S] binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.2   0.0   2.6e-11   7.8e-08      36      73 ..       1      37 [.       1      40 [. 0.92

  Alignments for each domain:
  == domain 1  score: 32.2 bits;  conditional E-value: 2.6e-11
      Fer2_2 36 msaaalleenepkpteeeirealsgnlCRCtgYrpivd 73
                ms+++ll++  +kpt ++i+  l+gnlCRCtgYr+i+d
  EFC38975.1  1 MSLYSLLRNY-SKPTIKQIELSLDGNLCRCTGYRSILD 37
                8999**9888.89999********************98 PP

>> DUF3481  C-terminal domain of neuropilin glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.3     0.071   2.1e+02      40      67 ..      27      55 ..      22      64 .. 0.80
   2 ?    7.8   0.3   0.00088       2.6      54      77 ..     219     242 ..     193     245 .. 0.81
   3 ?    1.6   0.0     0.077   2.3e+02      37      60 ..     556     579 ..     550     584 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.071
     DUF3481 40 cacs.qaslsdrnlsalenynfelvdGvk 67
                c c+ + s+ d ++s  ++yn +l d + 
  EFC38975.1 27 CRCTgYRSILDMAISLSDEYNHDLNDNIN 55
                556436779999**************997 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00088
     DUF3481  54 alenynfelvdGvklkkeklnaqk 77 
                  +enyn+ l + +kl  ekln ++
  EFC38975.1 219 FIENYNLILENSIKLLNEKLNLNE 242
                 48******************9775 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.077
     DUF3481  37 vlycacsqaslsdrnlsalenynf 60 
                 vl cac  ++l +++   l n  f
  EFC38975.1 556 VLACACAIGALKSQQTVRLWNVIF 579
                 899********9999888887666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (585 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       677  (0.0377601); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 3578.97
//
Query:       EFC38976.1  [L=276]
Description: hypothetical protein NAEGRDRAFT_81426 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2100  (0.117129); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 1693.69
//
Query:       EFC38977.1  [L=1608]
Description: hypothetical protein NAEGRDRAFT_81427 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-18   67.1   0.0    3.3e-18   65.9   0.0    1.6  1  Lipase_3  Lipase (class 3)
    5.2e-05   23.5  19.9    0.00026   21.3   5.2   11.6 12  EGF_2     EGF-like domain
    0.00078   19.1   0.4     0.0038   16.8   0.4    1.9  1  DUF2974   Protein of unknown function (DUF2974)
  ------ inclusion threshold ------
       0.03   14.3   3.6        2.8    8.0   0.2    3.5  3  Y_Y_Y     Y_Y_Y domain
       0.13   12.1   0.1       0.28   11.1   0.1    1.5  1  DUF4572   Domain of unknown function (DUF4572)


Domain annotation for each model (and alignments):
>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.9   0.0   9.1e-22   3.3e-18       1     129 [.     111     231 ..     111     234 .. 0.93

  Alignments for each domain:
  == domain 1  score: 65.9 bits;  conditional E-value: 9.1e-22
                 EEEE----------------EEE-HHHH-GTT-EEEHHHHHHHHS-HHHHHHHHHHHHHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS---EEE CS
    Lipase_3   1 vvafRGtesakdwltdldfslteakellekeggkvhsgfleayeeslreqvlkelkrllekypeysivvtGHSLGgalAlLaaldlvengenekkkvtv 99 
                 v++fRGt+   dw++++++ ++++  +++   + +h gfl  +      + ++ lk+ ++ y  y+i+ tGHS GgalA +aa+ + ++ +   +++++
  EFC38977.1 111 VFSFRGTDGYLDWIQNFEAVPVPYAITPTT-TIWLHAGFLFEIL-----EYKQILKNFVNGYSGYRIIWTGHSQGGALAQVAATIIGQELSIPMDRAQL 203
                 689**********************99775.9*******96666.....688999999********************************999****** PP

                 EEES----B-HHHHHHHHT-TTEEEEEEEE CS
    Lipase_3 100 vtfGqPrvgnkefaklvdsqlnkkvlrvvn 129
                 +tfG+P  g  +fa++ ++++++  +r+vn
  EFC38977.1 204 ITFGSPAAGMDNFANFASKKVKH--TRIVN 231
                 ******************88777..88887 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -6.6   8.1         5   1.8e+04      22      32 .]     400     410 ..     384     410 .. 0.74
   2 !    8.4  17.0   0.00076       2.7       1      32 []     442     470 ..     442     470 .. 0.87
   3 ?   -7.7   6.5         5   1.8e+04      14      32 .]     482     500 ..     475     500 .. 0.67
   4 ?   -1.4   9.7      0.87   3.1e+03       1      32 []     504     529 ..     504     529 .. 0.80
   5 !   21.3   5.2   7.2e-08   0.00026       6      32 .]     877     902 ..     873     902 .. 0.92
   6 !   17.9   6.7     8e-07    0.0029       5      32 .]     915     941 ..     911     941 .. 0.90
   7 ?   -4.0   0.6         5   1.8e+04      22      28 ..     958     964 ..     954     967 .. 0.78
   8 ?   -4.2  10.1         5   1.8e+04       2      32 .]     975     999 ..     970     999 .. 0.79
   9 ?    1.2  11.6      0.14   4.9e+02      13      32 .]    1011    1031 ..    1004    1031 .. 0.81
  10 ?   -1.5  11.9      0.95   3.4e+03       1      32 []    1035    1060 ..    1035    1060 .. 0.85
  11 ?   -4.3  10.0         5   1.8e+04      14      32 .]    1072    1090 ..    1064    1090 .. 0.71
  12 ?   -8.1   7.8         5   1.8e+04      12      32 .]    1099    1119 ..    1092    1119 .. 0.70

  Alignments for each domain:
  == domain 1  score: -6.6 bits;  conditional E-value: 5
       EGF_2  22 dCdsgyqGktC 32 
                 +C +g++G+ C
  EFC38977.1 400 SCVNGFYGPLC 410
                 599******99 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00076
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C + +++C  +G+C+   G+C+C+sgy G +C
  EFC38977.1 442 CAPKCTNCA-NGQCI--DGVCVCNSGYGGVNC 470
                 766677776.7****..************999 PP

  == domain 3  score: -7.7 bits;  conditional E-value: 5
       EGF_2  14 CvnqcGqC.dCdsgyqGktC 32 
                 C ++   C +C +  +G+tC
  EFC38977.1 482 CTTPY-LCsSCLPRTFGATC 500
                 55444.56358999999999 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 0.87
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C +++++C+ + tC       +Cd+g++G tC
  EFC38977.1 504 CIPNCLTCSDDKTCT------KCDAGFTGQTC 529
                 666677777777777......59********* PP

  == domain 5  score: 21.3 bits;  conditional E-value: 7.2e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G+C+++   C+C++gy G +C
  EFC38977.1 877 NVCSGNGICEELD-MCYCKTGYAGINC 902
                 68********899.9************ PP

  == domain 6  score: 17.9 bits;  conditional E-value: 8e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g G+C +++ +C+C++gy G +C
  EFC38977.1 915 ASVCSGIGSCLSPN-NCSCPNGYNGTNC 941
                 578********999.8************ PP

  == domain 7  score: -4.0 bits;  conditional E-value: 5
       EGF_2  22 dCdsgyq 28 
                 +C+sg++
  EFC38977.1 958 SCKSGFY 964
                 4899987 PP

  == domain 8  score: -4.2 bits;  conditional E-value: 5
       EGF_2   2 sasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   ++e C+  +tC+      +C +g  G +C
  EFC38977.1 975 LVNCEVCSSSETCN------KCLDGLKGQYC 999
                 445999********......47888888877 PP

  == domain 9  score: 1.2 bits;  conditional E-value: 0.14
       EGF_2   13 tCvnqcGqC.dCdsgyqGktC 32  
                  tC +++G C +C+ gy+G +C
  EFC38977.1 1011 TCSTSTGDClECNEGYYGSYC 1031
                  79889999966********** PP

  == domain 10  score: -1.5 bits;  conditional E-value: 0.95
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C++++  C+   +C   +    C sg++G+tC
  EFC38977.1 1035 CPSNCKSCSSEVSCS--T----CRSGWTGPTC 1060
                  888878888888888..7....********** PP

  == domain 11  score: -4.3 bits;  conditional E-value: 5
       EGF_2   14 CvnqcGqC.dCdsgyqGktC 32  
                  C +++ qC +C++g +G +C
  EFC38977.1 1072 CSSPN-QCsKCFNGLYGSDC 1090
                  44444.7846********** PP

  == domain 12  score: -8.1 bits;  conditional E-value: 5
       EGF_2   12 GtCvnqcGqC.dCdsgyqGktC 32  
                  ++C+n++  C  C++  +G  C
  EFC38977.1 1099 ESCINST-SClTCPPYSSGSMC 1119
                  4677777.57448999999888 PP

>> DUF2974  Protein of unknown function (DUF2974)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.4   1.1e-06    0.0038      32     110 ..     103     195 ..      83     235 .. 0.66

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.1e-06
     DUF2974  32 frleedtlvvaFRGTddtlvgWkedfnm.....afrsevpaqesAlkYlnkileeseg...........kiylgGhSkGGnlAvyaamnaeddlq 110
                 ++ +e+++v +FRGTd+  ++W ++f+      a +++++   + + +l +ile  +            +i+ +GhS+GG lA+ aa  + ++l+
  EFC38977.1 103 VSTSEKKIVFSFRGTDG-YLDWIQNFEAvpvpyAITPTTTIWLH-AGFLFEILEYKQIlknfvngysgyRIIWTGHSQGGALAQVAATIIGQELS 195
                 45568889999999976.56999999852221133333333333.3444444433333445555566667*****************99888877 PP

>> Y_Y_Y  Y_Y_Y domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.1       0.5   1.8e+03      37      47 ..     274     284 ..     264     286 .. 0.81
   2 ?    4.8   0.1    0.0075        27      27      44 ..     334     360 ..     328     360 .. 0.72
   3 ?    8.0   0.2   0.00077       2.8      31      53 ..    1334    1356 ..    1317    1365 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.5
                 -SEEEEEEEEE CS
       Y_Y_Y  37 ppGdYtlkVka 47 
                 + G+Y+l+V+ 
  EFC38977.1 274 SMGNYQLQVRN 284
                 67*******85 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0075
                 TS..........EEEEES--SEEEEEE CS
       Y_Y_Y  27 ysq.........easytnlppGdYtlk 44 
                 y+q         ++ +t lppG Y+l+
  EFC38977.1 334 YNQqaqlpckgeQIDITSLPPGVYELQ 360
                 4444445555669***********986 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.00077
                  EEEES--SEEEEEEEEEEETTS- CS
       Y_Y_Y   31 asytnlppGdYtlkVkakdndgq 53  
                   +y n  +Gd+t++V++k+++g+
  EFC38977.1 1334 REYLNYYSGDFTFQVYVKSPEGD 1356
                  6788999************9987 PP

>> DUF4572  Domain of unknown function (DUF4572)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   7.9e-05      0.28      74     169 ..      24     120 ..      14     126 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 7.9e-05
     DUF4572  74 vllkkefkeikt.rksllneeslasailerdeglpktgfgavlprhppdrrkmeleTtykedYrppypyepakeplpedyslvhrkcrsqftdlegs 169
                 + +++e++e  + r+++   +   s    + +g  ++++ a  +  + +++  ++++ty  +Y++ y y+++ +  +  +s+ ++k++ +f  ++g+
  EFC38977.1  24 TVVASEYNESVIaRRMMERGHPERSFYEPYYTGYFNRDVYAAAVLSNDAYNDLSTSSTYVPEYTLVYRYHESVSVFNIYVSTSEKKIVFSFRGTDGY 120
                 56788898888855555555666666777788999999999999999*********************************************99997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1608 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1145  (0.063863); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.07u 0.34s 00:00:01.41 Elapsed: 00:00:00.56
# Mc/sec: 8689.76
//
Query:       EFC38978.1  [L=279]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-22   80.5   7.7    1.4e-22   80.5   7.7    2.3  2  DUF2306   Predicted membrane protein (DUF2306)


Domain annotation for each model (and alignments):
>> DUF2306  Predicted membrane protein (DUF2306)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.3      0.23     4e+03      46      73 ..      38      65 ..      34      70 .. 0.68
   2 !   80.5   7.7   7.9e-27   1.4e-22       2     147 .]     103     273 ..     102     273 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.23
     DUF2306 46 alsglflsvyatgglvlllgflllallw 73
                  s+ +l+++   g ++++g + +a++ 
  EFC38978.1 38 SSSSSWLKSLLKYGSWVVVGTGWAAVMG 65
                5677788888777877777777666654 PP

  == domain 2  score: 80.5 bits;  conditional E-value: 7.9e-27
     DUF2306   2 vlHialalvalllGalqlvkrlrakrpklHrlaGrvyvlavllaalsglflsvyatgglvlllgflllallwlvftvlalvairrrd............ 88 
                 +lH ++++v l lG++q+ +++ra++ klH+++G+++  +++l a+ ++ l  y++ggl+++  f ll ++w++++  a+  ++ +             
  EFC38978.1 103 ALHASCGMVCLGLGIFQFQESFRARHMKLHKWMGYIFNSSIVLGAIGSIGLIPYSAGGLATKSAFTLLTSIWVGTMGMAMAYVLPKWinpfkslinkek 201
                 79*****************************************************************************99999998888899999999 PP

     DUF2306  89 ...faaHrawmirsYalalaavtlrlvllvlil..........lvgedfetayavlsllawvpnlvvaelli 147
                    +++Hr+wmir Ya  ++ + lr++l+++ +           v+ + + +y+  ++l++v nl++ e++i
  EFC38978.1 202 eyrIQKHREWMIRCYATVMSSISLRVYLALFTVynifqqkegiNVDAAVKDSYTSSVWLSFVTNLILSEIYI 273
                 999**************************************9999999********************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1141  (0.0636399); expected 358.6 (0.02)
Passed bias filter:                      647  (0.0360868); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 1693.94
//
Query:       EFC38979.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       800  (0.0446204); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2085.51
//
Query:       EFC38980.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.8e-13   51.5   0.7    3.1e-13   50.7   0.7    1.4  1  Metallophos    Calcineurin-like phosphoesterase
    1.1e-10   41.9   0.1    4.1e-10   40.1   0.1    1.8  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.7   0.7   3.5e-17   3.1e-13       1     203 [.      68     252 ..      68     253 .. 0.74

  Alignments for each domain:
  == domain 1  score: 50.7 bits;  conditional E-value: 3.5e-17
                  EEEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSSHHHHHHHHHHHHHHHH.TSEEEEEC-TTSCHHHHHHHHHHHHHHHHHHHEH CS
  Metallophos   1 lrilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrgdlekellellaalvky.pipvylllGNHegfeeellnkygylgifsepwrs 97 
                  l++++i+D+H      + +d l+l        + d+++++GD +d+g le  ++++ ++++ +  ++++++ GNHe  +++ l k++ +++fs+ ++ 
   EFC38980.1  68 LKFVIISDTH------NKHDMLQLP-------EGDVFIHCGDMTDEGKLED-IEKFNQWVGTLpYKHKIVICGNHE-VDISKLGKEKIQELFSNAIYL 150
                  58999****9......555555544.......78*************8887.7777777777643456********.899999999989999666666 PP

                  HHCEEETSEEEEEETTE.EEEEEEESECEEETHH.HHHHHHHHHSCHHHHCCHHHHHHHHHHTTCSEEEEEESSESS...CSSSCSCCHHHHHHHHHH CS
  Metallophos  98 daevfnnlplaslgsgs.lkvlllhGgspellvs.ldklgslnleleapepgdewlkdlekrekadwvivlgHsply...rgsgylfgdealedllkk 190
                  +++ + +  +  +g+ +  +   l+G+     ++  ++ ++  +++      +e l++  +  + d+ i+++H p+    +g+ ++ ++  + +  + 
   EFC38980.1 151 ENSSVVIEGVKIYGTPYiPNMSDLPGE----KKEyMCQFDNDYFYRS-----EEKLAEIFATIDPDTNILVTHTPPKghlDGILKYGSPSLMTRMNEL 239
                  655555666666667756556666666....2330444444444444.....3444444555899**************9999999999999999999 PP

                  TTESEEEEESSSS CS
  Metallophos 191 ygvdlvisGHtHv 203
                  +++++ ++GH+H 
   EFC38980.1 240 KDLKVNCFGHVHM 252
                  ************6 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.1   0.1   4.5e-14   4.1e-10       2     145 ..      69     270 ..      68     278 .. 0.72

  Alignments for each domain:
  == domain 1  score: 40.1 bits;  conditional E-value: 4.5e-14
  Metallophos_2   2 klaiiSDlHsnldaleavlealkevgvdaiihaGDl.eeeepevleellela......pvlaVrGNnD............................ 62 
                    k++iiSD+H n +   ++     e   d  ih+GD+  e+++e +e++ +          ++++GN++                            
     EFC38980.1  69 KFVIISDTH-NKHDMLQL----PEG--DVFIHCGDMtDEGKLEDIEKFNQWVgtlpykHKIVICGNHEvdisklgkekiqelfsnaiylenssvvi 157
                    89*******.44444445....555..99******99888888888888888999999899********9*****999999999999999999999 PP

  Metallophos_2  63 ..................eevveedvlreaaelgtdl.......peeaelel.....agekvlliHgdpl........gvkdalaellkeaeegsd 120
                                      +         e++e++ ++        ee+  e+     +++++l++H  p+            +  +l+ ++ e +d
     EFC38980.1 158 egvkiygtpyipnmsdlpG---------EKKEYMCQFdndyfyrSEEKLAEIfatidPDTNILVTHTPPKghldgilkY---GSPSLMTRMNELKD 241
                    9999887765544433221.........222222222444455435555554555678888******999***996553...44444444444444 PP

  Metallophos_2 121 ..vvvcGHtHvp.eveke.ggvlvvnPGs 145
                      v ++GH H+  + ek+ +gv+v+n+ s
     EFC38980.1 242 lkVNCFGHVHMGyGYEKIqNGVTVINAAS 270
                    45*********97455553699***9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1779.60
//
Query:       EFC38981.1  [L=738]
Description: hypothetical protein NAEGRDRAFT_59370 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   1.6e-106  347.9  20.1    6.2e-19   67.5   0.0   10.4 11  DUF4116         Domain of unknown function (DUF4116)
    2.5e-24   86.0   0.8    2.5e-24   86.0   0.8    1.9  2  Pkinase         Protein kinase domain
      7e-11   41.9   0.1    9.9e-09   34.9   0.1    2.4  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0038   16.1   0.1      0.006   15.4   0.1    1.3  1  Pkinase_fungal  Fungal protein kinase
     0.0048   16.3   0.9       0.92    8.8   0.1    3.5  4  DUF3523         Domain of unknown function (DUF3523)
  ------ inclusion threshold ------
       0.07   13.3   0.0        5.5    7.1   0.0    3.3  4  DUF4853         Domain of unknown function (DUF4853)
      0.097   13.2   0.3        2.2    8.8   0.0    2.5  2  AvrPtoB_bdg     Avirulence AvrPtoB, BAK1-binding domain
      0.099   12.7   0.0         63    3.7   0.0    4.2  4  DUF1667         Protein of unknown function (DUF1667)
        1.4    8.7   5.4        7.5    6.4   0.0    4.1  5  zf_C2H2_6       Zinc Finger domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       2.6   5.1e+03       4      21 ..      87     104 ..      86     111 .. 0.80
   2 ?   -3.7   0.0       5.3   1.1e+04      21      28 ..     216     223 ..     212     232 .. 0.82
   3 !   29.6   0.0   2.2e-10   4.3e-07       7      44 ..     306     344 ..     300     348 .. 0.89
   4 !   31.1   0.1   7.3e-11   1.5e-07       1      35 [.     350     385 ..     350     396 .. 0.86
   5 !   22.1   0.1   4.7e-08   9.3e-05      16      46 ..     395     425 ..     384     427 .. 0.84
   6 !   53.2   0.4   8.6e-18   1.7e-14       1      49 []     429     477 ..     429     477 .. 0.99
   7 !   45.0   0.0   3.2e-15   6.4e-12       1      49 []     454     502 ..     454     502 .. 0.98
   8 !   44.5   0.0   4.7e-15   9.3e-12       1      49 []     504     552 ..     504     552 .. 0.99
   9 !   67.5   0.0   3.1e-22   6.2e-19       1      49 []     554     602 ..     554     602 .. 0.99
  10 !   64.2   0.0   3.2e-21   6.4e-18       1      49 []     632     680 ..     632     680 .. 0.99
  11 !   24.2   0.0     1e-08     2e-05       1      29 [.     682     710 ..     682     716 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.6
     DUF4116   4 ivleavkkngsalkylse 21 
                 +vl+++ +++ al+ ls 
  EFC38981.1  87 MVLQIIVQCCGALQSLSL 104
                 689999999999998885 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 5.3
     DUF4116  21 eeLknDke 28 
                 eeL nD+e
  EFC38981.1 216 EELWNDIE 223
                 7999**98 PP

  == domain 3  score: 29.6 bits;  conditional E-value: 2.2e-10
     DUF4116   7 eavkkngsalkyls.eeLknDkeivlkAvkqngtalsya 44 
                  +++kng++l+++s e++   ke+vl +vkqng +l+ya
  EFC38981.1 306 YVCEKNGLNLQFVSpEDFLIEKELVLGCVKQNGMSLEYA 344
                 589**********7366********************98 PP

  == domain 4  score: 31.1 bits;  conditional E-value: 7.3e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk.Avk 35 
                 D Eiv+ea+++n++a+ y+s +L nD +i+ + A+ 
  EFC38981.1 350 DFEIVMEAITQNSNAIMYASTKLLNDQQIIYQvALM 385
                 88****************************995555 PP

  == domain 5  score: 22.1 bits;  conditional E-value: 4.7e-08
     DUF4116  16 lkylseeLknDkeivlkAvkqngtalsyase 46 
                 l   seeLkn++e++lk+++  g al+ +++
  EFC38981.1 395 LSLTSEELKNNREFMLKIMELKGQALCCIPH 425
                 33448********************998885 PP

  == domain 6  score: 53.2 bits;  conditional E-value: 8.6e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+vl+avk++g+al+y  e+L+nDk+++++A++ +g ++syaseeL+
  EFC38981.1 429 DKEMVLKAVKNYGNALYYSCENLRNDKDVIIEAMNTDGGSFSYASEELK 477
                 9*****************99***************************97 PP

  == domain 7  score: 45.0 bits;  conditional E-value: 3.2e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D++++ ea+ ++g ++ y+seeLk+D+ iv +A+k++g++l ya++ Lr
  EFC38981.1 454 DKDVIIEAMNTDGGSFSYASEELKKDRHIVTEAIKRDGNNLGYACKALR 502
                 9********************************************9997 PP

  == domain 8  score: 44.5 bits;  conditional E-value: 4.7e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D Eiv  a++kng++lk++  ++k +k i+++Avk+n++al ++ eeLr
  EFC38981.1 504 DLEIVSLAIRKNGNSLKFCGTSFKGNKIIAMEAVKNNPIALQHCTEELR 552
                 89**********************************************8 PP

  == domain 9  score: 67.5 bits;  conditional E-value: 3.1e-22
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+ivl av+ +g +l+y+s++L+nDke+v+kAv++ng+++++aseeL+
  EFC38981.1 554 DRDIVLAAVQLDGIVLEYASDRLRNDKEVVMKAVQNNGSSFRFASEELK 602
                 9**********************************************97 PP

  == domain 10  score: 64.2 bits;  conditional E-value: 3.2e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +rE++l+ v++ng++l+y+seeLknD+++vl+A+ +ng+al++aseeLr
  EFC38981.1 632 NRELALQKVQQNGLNLEYVSEELKNDRQVVLAAISKNGNALKFASEELR 680
                 8***********************************************8 PP

  == domain 11  score: 24.2 bits;  conditional E-value: 1e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkei 29 
                 D++iv+ av   ++ lk++s+eLkn++e+
  EFC38981.1 682 DKQIVTAAVLEIPYTLKFASNELKNNREF 710
                 9***************************9 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.0   0.8   1.3e-27   2.5e-24      26     260 ..       6     273 ..       1     276 [. 0.80
   2 ?   -2.5   0.1       1.3   2.6e+03     207     248 ..     687     729 ..     672     732 .. 0.62

  Alignments for each domain:
  == domain 1  score: 86.0 bits;  conditional E-value: 1.3e-27
                 EEEEEEEECHCHCHHHHHHHHHH.HHHHHHHSCTTB--EEEEEEE........SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHH CS
     Pkinase  26 ivAvKkikkekakkkkekkvlrE.ikilkklkhpnivrlyevfee........kdelylvleyveggeladllerkgslseeeakkiakqilegleylH 115
                  ++ K+i  ++   ++  ++++E ++  k+++h n++ ++ + +         + + y++    +g++l d+ ++   +s   + +i+ q + +l+ l 
  EFC38981.1   6 LMVFKIIHDDSGLLETG-ETRSEyLQKYKHTNHANVLSMKTFNNYndddeasiTLREYVIISKFRGNNLRDVRKNLERVSILMVLQIIVQCCGALQSLS 103
                 56666666666555554.34444267788999****999887665555444442223344444556669998888788999999*************** PP

                 HTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS........................BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHH CS
     Pkinase 116 skgiiHrDlKpeNiLidekgelKitDFGlakelesssk........................ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyel 190
                  ++iiHrD+KpeNi+++e+g++ ++D+G a+ +e++ +                        +t f gt  ++APE+l + + s k+D++slG++++++
  EFC38981.1 104 LNHIIHRDVKPENIFMSEEGMIVLGDLGCATMAENNLDdmlllneenneqlvddctsscyssATGFAGTIGFIAPEIL-NGKCSCKCDIFSLGITILSF 201
                 ***********************************9999*********************99999*************.56689**********99997 PP

                 HH.SS-STTTSSHHHHHHHHHHT.HHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 191 lt.gkppfsgekgkekvekeldq.lekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellq 260
                 l+  +  ++ + ++e+ ++++++ +++i+   ++t  +++++ +    +kdl+k + +  + +R+++e++ q
  EFC38981.1 202 LFlDRFHLQLKYQQEELWNDIETlFQNIITNTTTTISEFENDPSSWIVIKDLCKGMTCIHEDNRYSIENIFQ 273
                 76266778888999999999999444444444466666666666666789******************9988 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.3
                 HHHHHTHHHHHHHCT.SHH...HHHTTS-HHHHHHHHHHT-SS CS
     Pkinase 207 ekeldqlekilkilg.etkeklpeaseiseeakdllkkllkkd 248
                 ++ + ++  +lk    e k++ +  +e+++e+++l+ k ++ +
  EFC38981.1 687 TAAVLEIPYTLKFASnELKNNREFTTELEKEMQKLIPKYISLK 729
                 3333333333333335677788888888999999998877665 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   0.1     5e-12   9.9e-09      53     195 ..      30     198 ..       4     227 .. 0.67

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 5e-12
                  HHHHTS-BTTB--EEEEEE...SSSS.......EEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETT CS
  Pkinase_Tyr  53 kimkklkhpnivkllgvct...keep.......llivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenk 140
                  +  k+++h n++++  +     +           ++++   +g++L++  rk+  e++++  +l++++q + +++ L+ ++++Hrd+   N+++se+ 
   EFC38981.1  30 QKYKHTNHANVLSMKTFNNyndD--DeasitlrEYVIISKFRGNNLRDV-RKN-LERVSILMVLQIIVQCCGALQSLSLNHIIHRDVKPENIFMSEEG 123
                  45567788888888777766532..134455555666666677777774.666.89****************************************** PP

                  EEEE-STTTHEETTTSSEE.....................EETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHH CS
  Pkinase_Tyr 141 vvkisDfGLardiekddey.....................vkkeeaklpvkWmapEslkekkftsksDvWsfGvll 195
                  ++ ++D G a   e++ +                      +++++    + ++apE+l+ +k++ k D++s G+++
   EFC38981.1 124 MIVLGDLGCATMAENNLDDmlllneenneqlvddctsscySSATGFAGTIGFIAPEILN-GKCSCKCDIFSLGITI 198
                  *******9887664321111122111111222222222213333344556677777654.5677777777777776 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.1     3e-06     0.006     304     388 ..      84     183 ..      24     226 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3e-06
  Pkinase_fungal 304 spkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddsses......................garertG 376
                     s + +l+ + ++  +++sL     i+HrD+  +Ni +      +e   +L DL  a+  +++   +                      +a    G
      EFC38981.1  84 SILMVLQIIVQCCGALQSLS-LNHIIHRDVKPENIFMS-----EEGMIVLGDLGCATMAENNLD-DmlllneenneqlvddctsscysSATGFAG 171
                     4566899999**********.999**************.....455666677777766664222.224444443333443443333333355899 PP

  Pkinase_fungal 377 TleFmaievlkg 388
                     T+ F+a e+l+g
      EFC38981.1 172 TIGFIAPEILNG 183
                     999999999985 PP

>> DUF3523  Domain of unknown function (DUF3523)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.89   1.8e+03     194     229 ..     426     461 ..     422     465 .. 0.88
   2 ?   -0.9   0.0      0.44   8.7e+02     192     226 ..     474     508 ..     469     513 .. 0.85
   3 ?    3.1   0.1     0.026        52     178     230 ..     535     587 ..     529     591 .. 0.91
   4 !    8.8   0.1   0.00046      0.92     175     230 ..     635     690 ..     629     695 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.89
     DUF3523 194 akeeretvlesiktafsviGgGlralltdkdklvaa 229
                  ++++e vl+++k  ++ +    ++l +dkd ++ a
  EFC38981.1 426 FNNDKEMVLKAVKNYGNALYYSCENLRNDKDVIIEA 461
                 67899************************9988876 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.44
     DUF3523 192 ekakeeretvlesiktafsviGgGlralltdkdkl 226
                 e+ k++r+ v e+ik  ++ +G   +al +d + +
  EFC38981.1 474 EELKKDRHIVTEAIKRDGNNLGYACKALRNDLEIV 508
                 67889999*****************9999997755 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.026
     DUF3523 178 eerenedlnleqlrekakeeretvlesiktafsviGgGlralltdkdklvaav 230
                 e+ +n+ + l++  e+ + +r+ vl++++  + v++   + l +dk+ ++ av
  EFC38981.1 535 EAVKNNPIALQHCTEELRDDRDIVLAAVQLDGIVLEYASDRLRNDKEVVMKAV 587
                 55678889999************************************999988 PP

  == domain 4  score: 8.8 bits;  conditional E-value: 0.00046
     DUF3523 175 rakeerenedlnleqlrekakeeretvlesiktafsviGgGlralltdkdklvaav 230
                  a ++ +++ lnle + e+ k++r+ vl++i+  ++ +    ++l +dk+ ++aav
  EFC38981.1 635 LALQKVQQNGLNLEYVSEELKNDRQVVLAAISKNGNALKFASEELRNDKQIVTAAV 690
                 56777788999***************************************999998 PP

>> DUF4853  Domain of unknown function (DUF4853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.8   3.5e+03     104     131 ..     453     480 ..     448     484 .. 0.80
   2 ?   -0.5   0.0      0.64   1.3e+03      65     110 ..     477     521 ..     459     526 .. 0.73
   3 ?    0.8   0.0      0.25   4.9e+02      68     123 ..     555     597 ..     549     607 .. 0.56
   4 ?    7.1   0.0    0.0028       5.5      63     111 ..     628     675 ..     617     685 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.8
                 TS-EEEEEE-SS.EEEEEEE---B--SS CS
     DUF4853 104 yGgslsvkyseddrisvhyesgclpsdg 131
                 +   + ++++ +d+ s++y s+ l  d+
  EFC38981.1 453 NDKDVIIEAMNTDGGSFSYASEELKKDR 480
                 556688888999999*****99998776 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.64
                 HHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEE CS
     DUF4853  65 ddlrevveeelkplGfkysekpderdkdesrtvvwgderyGgslsv 110
                 ++ r +v+e++k++G ++    +  ++d + + ++  + +G+sl++
  EFC38981.1 477 KKDRHIVTEAIKRDGNNLGYACKALRNDLEIVSLAIRK-NGNSLKF 521
                 45588999999999988888888877777775555555.7888776 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.25
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEEEE-SS.EEEEEEE CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyGgslsvkyseddrisvhye 123
                 r++v ++++ +G +++   d+ ++d++ ++ +  + +G s             ++ 
  EFC38981.1 555 RDIVLAAVQLDGIVLEYASDRLRNDKEVVMKAVQN-NGSSF------------RFA 597
                 55666666666666666666666666665533333.35444............444 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0028
                 -HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEEE CS
     DUF4853  63 dfddlrevveeelkplGfkysekpderdkdesrtvvwgderyGgslsvk 111
                 +  d re++ ++++++G++++   +e ++d + ++++ ++ +G+ l++ 
  EFC38981.1 628 SIIDNRELALQKVQQNGLNLEYVSEELKNDRQVVLAAISK-NGNALKFA 675
                 5667899*******************************99.*****996 PP

>> AvrPtoB_bdg  Avirulence AvrPtoB, BAK1-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.0    0.0011       2.2      13      65 ..      51     108 ..      42     113 .. 0.82
   2 ?    1.3   0.0      0.24   4.8e+02      15      39 ..     631     655 ..     629     675 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0011
                  HHHHHHHHHHHHH....CTT--HHHHHHHHHHH.HHH-----HHHHHHHHCTT--S-- CS
  AvrPtoB_bdg  13 gndeadaalrglv....qqgvnlehlrtalerh.vmqrlpipldigsalqnvginpsi 65 
                   +dea  +lr  v     +g nl  +r  ler  ++  l i ++   alq + +n  i
   EFC38981.1  51 DDDEASITLREYViiskFRGNNLRDVRKNLERVsILMVLQIIVQCCGALQSLSLNHII 108
                  46899999999883333479************6377899*************999876 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.24
                  HHHHHHHHHHHCTT--HHHHHHHHH CS
  AvrPtoB_bdg  15 deadaalrglvqqgvnlehlrtale 39 
                  d+ + al+ + q+g+nle++   l+
   EFC38981.1 631 DNRELALQKVQQNGLNLEYVSEELK 655
                  56678999999*******9988775 PP

>> DUF1667  Protein of unknown function (DUF1667)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0     0.067   1.3e+02       5      27 ..     470     492 ..     468     499 .. 0.88
   2 ?   -1.7   0.0       1.5     3e+03       5      26 ..     570     591 ..     545     600 .. 0.68
   3 ?    0.0   0.0      0.45     9e+02       5      27 ..     648     670 ..     647     674 .. 0.84
   4 ?    3.7   0.0     0.032        63       5      24 ..     673     692 ..     667     725 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.067
     DUF1667   5 eYakkEvtnpkRivtstvkvegg 27 
                 +Ya +E+++ + ivt  +k +g+
  EFC38981.1 470 SYASEELKKDRHIVTEAIKRDGN 492
                 6**************99998766 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.5
     DUF1667   5 eYakkEvtnpkRivtstvkveg 26 
                 eYa + + n k +v+  v+ +g
  EFC38981.1 570 EYASDRLRNDKEVVMKAVQNNG 591
                 5666666677777666666655 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.45
     DUF1667   5 eYakkEvtnpkRivtstvkvegg 27 
                 eY+ +E++n +++v + +  +g+
  EFC38981.1 648 EYVSEELKNDRQVVLAAISKNGN 670
                 79************998887765 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.032
     DUF1667   5 eYakkEvtnpkRivtstvkv 24 
                 ++a +E+ n k+ivt+ v  
  EFC38981.1 673 KFASEELRNDKQIVTAAVLE 692
                 79*************99865 PP

>> zf_C2H2_6  Zinc Finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       4.1   8.2e+03       9      20 ..     394     405 ..     394     407 .. 0.78
   2 ?   -1.1   0.1      0.79   1.6e+03       9      20 ..     468     479 ..     468     481 .. 0.82
   3 ?    6.4   0.0    0.0038       7.5       9      20 ..     593     604 ..     592     606 .. 0.95
   4 ?   -3.2   0.0       3.8   7.6e+03      10      20 ..     672     682 ..     671     682 .. 0.83
   5 ?    1.6   0.0      0.12   2.3e+02      10      23 ..     697     710 ..     695     713 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4.1
   zf_C2H2_6   9 sLRFsSpeLKke 20 
                 +L + S eLK +
  EFC38981.1 394 NLSLTSEELKNN 405
                 5778999***76 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.79
   zf_C2H2_6   9 sLRFsSpeLKke 20 
                 s+ + S eLKk+
  EFC38981.1 468 SFSYASEELKKD 479
                 5667899****8 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0038
   zf_C2H2_6   9 sLRFsSpeLKke 20 
                 s+RF S eLK++
  EFC38981.1 593 SFRFASEELKQD 604
                 89*********8 PP

  == domain 4  score: -3.2 bits;  conditional E-value: 3.8
   zf_C2H2_6  10 LRFsSpeLKke 20 
                 L+F S eL  +
  EFC38981.1 672 LKFASEELRND 682
                 89****99765 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.12
   zf_C2H2_6  10 LRFsSpeLKkeHEa 23 
                 L+F S eLK + E 
  EFC38981.1 697 LKFASNELKNNREF 710
                 99*******98775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (738 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       914  (0.0509789); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.78u 0.34s 00:00:01.12 Elapsed: 00:00:00.52
# Mc/sec: 4286.89
//
Query:       EFC38982.1  [L=743]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-23   81.9   2.6    6.1e-08   33.2   0.0    4.5  4  Ank_2     Ankyrin repeats (3 copies)
    7.4e-21   74.7   4.2    7.4e-21   74.7   4.2    2.9  2  DHHC      DHHC palmitoyltransferase
    1.6e-16   58.7   3.2    0.00056   20.2   0.0    6.4  5  Ank_3     Ankyrin repeat
    6.1e-16   58.3   1.2     0.0027   18.0   0.0    5.5  5  Ank_5     Ankyrin repeats (many copies)
    1.9e-15   57.0   2.5    1.6e-08   34.9   0.0    4.6  5  Ank_4     Ankyrin repeats (many copies)
    1.1e-12   47.7   1.2     0.0017   18.7   0.0    5.8  5  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.2   0.0     2e-11   6.1e-08      25      76 ..      51     122 ..      15     130 .. 0.72
   2 !   30.6   0.0   1.3e-10   3.9e-07      21      75 ..      94     170 ..      91     178 .. 0.78
   3 !   11.4   0.1   0.00013      0.38      48      73 ..     192     218 ..     170     227 .. 0.55
   4 !   14.7   0.0   1.2e-05     0.036      24      57 ..     246     284 ..     223     301 .. 0.69

  Alignments for each domain:
  == domain 1  score: 33.2 bits;  conditional E-value: 2e-11
       Ank_2  25 ngktaLhyAakngnleivklLleh..................ad..ndgrtpLhyAarsghleivklLlekg 76 
                    ++Lh+A+ +gn+++++lLl++                  +d  ++ +tpL+++++ g+l ++++L++++
  EFC38982.1  51 RFASPLHWACYYGNIDTIRLLLSYgaslktyvknrnvssnneQDidSEYQTPLMWCVQGGSLPCLQFLIQHY 122
                 3369******************9555666677666666554422535577*******99**********874 PP

  == domain 2  score: 30.6 bits;  conditional E-value: 1.3e-10
       Ank_2  21 dpnkngktaLhyAakngnleivklLleh..................ad....ndgrtpLhyAarsghleivklLlek 75 
                 d++++ +t+L++++++g+l ++++L++h                   +    ++g++ L++A++ +h+ iv++L+++
  EFC38982.1  94 DIDSEYQTPLMWCVQGGSLPCLQFLIQHymhsqhemdesnmvrtlfKEhvqkRTGYNLLMLAIQDDHISIVQYLMYH 170
                 4554669*******************9777777787776665555411444588*********99*********976 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 0.00013
       Ank_2  48 h.adndgrtpLhyAarsghleivklLl 73 
                 + +dn+ +t+Lh+A+ +g++  vk+ +
  EFC38982.1 192 KyLDNESHTILHWACYEGYEHQVKFII 218
                 145566666666666666666666655 PP

  == domain 4  score: 14.7 bits;  conditional E-value: 1.2e-05
       Ank_2  24 k.ngktaLhyAakngnleivklLleh...ad.ndgrtpL 57 
                 + +++ta h+ a++g+l+i+++Ll +   a+   g t L
  EFC38982.1 246 DtFNRTAFHWIARKGYLNIMRYLLMEfliAEkILGLTSL 284
                 23789*****************99644654333355554 PP

>> DHHC  DHHC palmitoyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   8.3         1     3e+03      51     119 ..     384     454 ..     374     485 .. 0.60
   2 !   74.7   4.2   2.5e-24   7.4e-21       8     132 ..     524     647 ..     518     649 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1
        DHHC  51 Fllfllylllllilalvlllialvklveeekkseflavtllkk..................llsilllvlsllfllllgllllfhly 119
                 + lf+++l ++ i+ ++l++  + +l ++ k+  + +v+  k                   +                +++l++++ 
  EFC38982.1 384 YPLFMIMLNIMPIYLAILIIPLVFYLHTKTKNY-VIRVSGSKHhgnirdllffglfpssilF---------------GLMVLFYNIL 454
                 457888888888777777776666666666664.4445554446886664444443333330...............3333333322 PP

  == domain 2  score: 74.7 bits;  conditional E-value: 2.5e-24
        DHHC   8 CstcniykpprskHcrvCnrcvlrfDHhCpwlnnciGerNykyFllfllylllllilalvlllialvklveeekkseflavtllkkllsilllvlsllf 106
                  s+  i+kp rsk+ rv++++v+rfDH+C+++ n iGe+N+  Fl+f+ +++++++l++ ++ ++l+ lv++++ s  + v l+++ +  + +++ ++f
  EFC38982.1 524 SSELLIRKPIRSKFDRVTDQIVIRFDHYCVYTLNPIGEKNHVKFLAFVYSVAISSFLFVNIAACSLYILVNDSDSSMLY-VVLMENPCITIATAYFIVF 621
                 5677899************************************************************999999997666.557777999999999**** PP

        DHHC 107 llllgllllfhlylilrnlTtieamk 132
                  l+ ++l + +++ ++ n T  e+mk
  EFC38982.1 622 SLFGSILSIQQTIAVMFNNTAFEMMK 647
                 ************************98 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.9e-07   0.00056       4      29 ..      54      78 ..      52      80 .. 0.93
   2 !   10.4   0.0   0.00028      0.84       2      24 ..      99     121 ..      98     124 .. 0.91
   3 !    8.2   0.0    0.0014       4.2       2      23 ..     148     169 ..     147     177 .. 0.88
   4 ?    4.6   0.0     0.022        67       3      23 ..     199     219 ..     197     224 .. 0.80
   5 !    9.8   0.1   0.00044       1.3       2      23 ..     249     270 ..     248     275 .. 0.92

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.9e-07
       Ank_3  4 tpLhlAarsgnleivkfLlenkgadv 29
                +pLh+A+ +gn++ +++Ll  +ga +
  EFC38982.1 54 SPLHWACYYGNIDTIRLLLS-YGASL 78
                8*******************.99976 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00028
       Ank_3   2 GetpLhlAarsgnleivkfLlen 24 
                 ++tpL++++  g+l+ ++fL+++
  EFC38982.1  99 YQTPLMWCVQGGSLPCLQFLIQH 121
                 79********************5 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0014
       Ank_3   2 GetpLhlAarsgnleivkfLle 23 
                 G+++L+lA+  ++++iv++L  
  EFC38982.1 148 GYNLLMLAIQDDHISIVQYLMY 169
                 99*****************976 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.022
       Ank_3   3 etpLhlAarsgnl.eivkfLle 23 
                  t+Lh+A+  g     vkf+++
  EFC38982.1 199 HTILHWACYEGYEhQ-VKFIIQ 219
                 59******9998854.777777 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.00044
       Ank_3   2 GetpLhlAarsgnleivkfLle 23 
                 ++t++h+ ar g l+i+++Ll 
  EFC38982.1 249 NRTAFHWIARKGYLNIMRYLLM 270
                 79******************96 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   8.9e-07    0.0027       9      45 ..      45      81 ..      38      87 .. 0.78
   2 !    7.7   0.0    0.0015       4.4      14      38 ..      97     121 ..      81     137 .. 0.80
   3 !   12.1   0.0   6.2e-05      0.19      14      39 ..     146     176 ..     140     187 .. 0.78
   4 ?    3.6   0.0      0.03        89      12      27 ..     194     209 ..     191     210 .. 0.82
   5 !   10.6   0.0   0.00019      0.56      12      36 ..     245     269 ..     242     277 .. 0.87

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 8.9e-07
       Ank_5  9 vnrldgggntpLhvAakygaadvvrlLlargadlnlt 45
                + + d++  +pLh+A++yg+ d +rlLl +ga+l+++
  EFC38982.1 45 NICDDERFASPLHWACYYGNIDTIRLLLSYGASLKTY 81
                444444444*******************999998865 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0015
       Ank_5  14 gggntpLhvAakygaadvvrlLlar 38 
                  + +tpL++ + +g+++++++L+ +
  EFC38982.1  97 SEYQTPLMWCVQGGSLPCLQFLIQH 121
                 2333******************944 PP

  == domain 3  score: 12.1 bits;  conditional E-value: 6.2e-05
       Ank_5  14 gggntpLhvAakygaadvvrlLl.....arg 39 
                 + g++ L++A+   + ++v++L+     +++
  EFC38982.1 146 RTGYNLLMLAIQDDHISIVQYLMyhlysNEN 176
                 6799******************955554444 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.03
       Ank_5  12 ldgggntpLhvAakyg 27 
                 ld+++ t+Lh+A++ g
  EFC38982.1 194 LDNESHTILHWACYEG 209
                 677888*******976 PP

  == domain 5  score: 10.6 bits;  conditional E-value: 0.00019
       Ank_5  12 ldgggntpLhvAakygaadvvrlLl 36 
                 +d +  t++h+ a++g+++++r+Ll
  EFC38982.1 245 KDTFNRTAFHWIARKGYLNIMRYLL 269
                 677778******************* PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.9   0.0   5.3e-12   1.6e-08       3      55 .]      54     119 ..      53     119 .. 0.90
   2 ?    3.8   0.0     0.031        93       5      54 ..     123     167 ..     121     168 .. 0.79
   3 !   11.1   0.1   0.00016      0.48       4      55 .]     151     218 ..     148     218 .. 0.77
   4 !   13.2   0.2   3.4e-05       0.1       3      55 .]     200     269 ..     198     269 .. 0.82
   5 ?    4.7   0.0     0.016        49       1      21 [.     249     269 ..     249     284 .. 0.86

  Alignments for each domain:
  == domain 1  score: 34.9 bits;  conditional E-value: 5.3e-12
       Ank_4   3 taLhyaaisgrlelvrlLlekgad............inaq.dnrsGetalhiAakrgnveilklLl 55 
                 ++Lh+a+++g+++++rlLl++ga+             n+q ++++ +t+l  ++++g++ +l++L+
  EFC38982.1  54 SPLHWACYYGNIDTIRLLLSYGASlktyvknrnvssNNEQdIDSEYQTPLMWCVQGGSLPCLQFLI 119
                 69***********************9999999987777775566688******************8 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.031
       Ank_4   5 LhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAakrgnveilklL 54 
                 +h++ ++    +vr L+   +    q  r G ++l  A++  +++i+++L
  EFC38982.1 123 MHSQHEMDESNMVRTLFKEHV----Q-KRTGYNLLMLAIQDDHISIVQYL 167
                 577777777788999995333....2.457999***************99 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 0.00016
       Ank_4   4 aLhyaaisgrlelvrlLlekgad...............inaq.dnrsGetalhiAakrgnveilklLl 55 
                 +L  a+++ ++ +v++L ++  +                +   ++++  t lh A++ g+ + +k+ +
  EFC38982.1 151 LLMLAIQDDHISIVQYLMYHLYSnengnvelttesiqdMYTKyLDNESHTILHWACYEGYEHQVKFII 218
                 5566777888899999887765556777778888876655557899999****************975 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 3.4e-05
       Ank_4   3 taLhyaaisgrlelvrlLl....ekgad..............inaqdnrsGetalhiAakrgnveilklLl 55 
                 t+Lh+a+++g +  v++++    ++ ++              i a ++   +ta+h  a++g+++i ++Ll
  EFC38982.1 200 TILHWACYEGYEHQVKFIIqffkYHSKEriemldfyqhlynfIVA-KDTFNRTAFHWIARKGYLNIMRYLL 269
                 89*****************66654555587788888887665444.488899*****************98 PP

  == domain 5  score: 4.7 bits;  conditional E-value: 0.016
       Ank_4   1 eltaLhyaaisgrlelvrlLl 21 
                 ++ta+h+ a +g l + r+Ll
  EFC38982.1 249 NRTAFHWIARKGYLNIMRYLL 269
                 578999999999999999998 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.0   5.7e-07    0.0017       4      27 ..      54      78 ..      53      84 .. 0.91
   2 !    8.5   0.0   0.00095       2.8       3      23 ..     100     121 ..      99     126 .. 0.90
   3 !    7.0   0.1    0.0028       8.4       2      23 ..     148     170 ..     147     183 .. 0.82
   4 ?    4.5   0.0     0.017        52       3      21 ..     199     217 ..     198     232 .. 0.69
   5 ?    2.0   0.0      0.11   3.3e+02       3      22 ..     250     269 ..     249     275 .. 0.90

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 5.7e-07
                BHHHHHHHHTTHHHHHHHH.TTTST CS
         Ank  4 TPLHlAatngkkriiklLL.hGAnl 27
                +PLH+A+++g+ + i+lLL +GA+l
  EFC38982.1 54 SPLHWACYYGNIDTIRLLLsYGASL 78
                6******************88*997 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00095
                 BBHHHHHHHHTTHHHHHHHH.T CS
         Ank   3 nTPLHlAatngkkriiklLL.h 23 
                  TPL++++++g++ ++++L+ h
  EFC38982.1 100 QTPLMWCVQGGSLPCLQFLIqH 121
                 5*****99***********965 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0028
                 SBBHHHHHHHHTTHHHHHHHH.T CS
         Ank   2 GnTPLHlAatngkkriiklLL.h 23 
                 G+  L+lA++ ++ +i+++L  h
  EFC38982.1 148 GYNLLMLAIQDDHISIVQYLMyH 170
                 8999*****888899****9654 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.017
                 BBHHHHHHHHTTHHHHHHH CS
         Ank   3 nTPLHlAatngkkriiklL 21 
                 +T LH+A+++g ++ +k++
  EFC38982.1 199 HTILHWACYEGYEHQVKFI 217
                 599*****87774444433 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.11
                 BBHHHHHHHHTTHHHHHHHH CS
         Ank   3 nTPLHlAatngkkriiklLL 22 
                 +T+ H+ a+ g ++i ++LL
  EFC38982.1 250 RTAFHWIARKGYLNIMRYLL 269
                 69***9899999*****998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (743 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       935  (0.0521501); expected 358.6 (0.02)
Passed bias filter:                      382  (0.0213063); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.74u 0.29s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 4367.37
//
Query:       EFC38983.1  [L=333]
Description: hypothetical protein NAEGRDRAFT_81431 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        3.6    7.8  10.8         29    4.8   8.7    2.9  2  DUF2852        Protein of unknown function (DUF2852)
        7.6    4.6  15.9         11    4.1  15.9    1.3  1  SSP160         Special lobe-specific silk protein SSP160
        8.8    5.2   8.2        7.9    5.3   7.1    1.4  1  CSG2           Ceramide synthase regulator


Domain annotation for each model (and alignments):
>> DUF2852  Protein of unknown function (DUF2852)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.07   4.2e+02      81     111 ..      28      58 ..      25      67 .. 0.82
   2 ?    4.8   8.7    0.0048        29      55     119 ..     243     309 ..     138     312 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.07
     DUF2852  81 deyreeeLerLeeeqreFeeflerLrrAkDk 111
                 d+++++ L++++  q  F++f +     kD 
  EFC38983.1  28 DAFKDRCLKKIDLVQILFKDFQSYTITHKDY 58 
                 99**************999997766666665 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0048
     DUF2852  55 fskakrereaaraskraaassGNaaFdeyreeeLerLeeeqr....eFeeflerLrrAkDkeeFdqFma 119
                   +++r+ ++  +++++  +   + ++ey+++  ++L e+ +    +++ +l++ ++ kD    +qF++
  EFC38983.1 243 SRAMSRKIDSILTQQTEIYEKKMEVYEEYKKKVAKKLKEKLNyieeNYNTYLNQVKQCKDDM--EQFIK 309
                 2233333335556666667777889************9998888889************964..46655 PP

>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1  15.9    0.0018        11     282     330 ..     155     203 ..     146     256 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0018
      SSP160 282 sanstssststststttststtttnsttstnstsssnsstiagsidiaa 330
                 + ++t+ ststs+s +t  +  +tn t++t +ts  n++ti  s + aa
  EFC38983.1 155 ALETTTPSTSTSSSVATRRTVQSTNNTSTTTTTSNRNTTTIKDSEEKAA 203
                 3456666777777777777777777777777777777777766655544 PP

>> CSG2  Ceramide synthase regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   7.1    0.0013       7.9      77     180 ..     159     262 ..     142     278 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0013
        CSG2  77 atkssvsekesskenklesnsessleleekvesdeeleekteeeklekvaekekkllsvstlkyvakllilslllviavltynlaLslsPafdvaliqn 175
                 +t s+ ++++ +++++++s++++s+++++++ +++++++ +e+   ++ ++++++++s+st+  + + +  s++   a  t + + ++s  +d  l q+
  EFC38983.1 159 TTPSTSTSSSVATRRTVQSTNNTSTTTTTSNRNTTTIKDSEEKAAKQRKTNEDETIFSKSTVLTLKRGMKQSITDDNAKCTVENSRAMSRKIDSILTQQ 257
                 3333334444446666777777777777777888888888888888888889**********999999999999999********************** PP

        CSG2 176 tsiFe 180
                 t i+e
  EFC38983.1 258 TEIYE 262
                 *9999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4346  (0.242401); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.80u 0.37s 00:00:01.17 Elapsed: 00:00:00.52
# Mc/sec: 1917.40
//
Query:       EFC38984.1  [L=2520]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.4e-51  170.2 357.7    0.00047   20.5   6.8   22.8 22  EGF_2         EGF-like domain
    2.7e-31  108.9   4.1    4.6e-31  108.2   4.1    1.4  1  Pkinase       Protein kinase domain
    3.5e-23   80.4   3.6    1.7e-05   24.6   0.0    6.1  5  NHL           NHL repeat
    1.9e-17   63.4   0.9    4.2e-17   62.3   0.9    1.5  1  Pkinase_Tyr   Protein tyrosine kinase
    0.00065   19.6   0.2     0.0015   18.4   0.2    1.5  1  TMEM154       TMEM154 protein family
     0.0083   16.0   1.1       0.02   14.8   1.1    1.5  1  Syndecan      Syndecan domain
  ------ inclusion threshold ------
      0.035   14.1   0.4       0.12   12.4   0.4    2.0  1  MA3           MA3 domain
      0.069   12.7   1.7       0.12   11.9   1.7    1.2  1  DUF5385       Family of unknown function (DUF5385)
       0.11   12.3   0.0       0.21   11.4   0.0    1.3  1  TMEM51        Transmembrane protein 51
       0.12   12.6   0.1       0.23   11.7   0.1    1.3  1  DUF4381       Domain of unknown function (DUF4381)
       0.13   12.3   0.8        4.4    7.3   0.2    2.7  2  Orthoreo_P17  Orthoreovirus P17 protein
        9.7    6.6 253.5      0.088   13.1   1.7   22.8 21  EGF           EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   8.9    0.0073        11       5      32 .]     359     387 ..     351     387 .. 0.77
   2 !    7.7   7.7     0.003       4.5       5      32 .]     400     428 ..     396     428 .. 0.73
   3 !   10.2   7.4   0.00053      0.79       6      32 .]     442     467 ..     438     467 .. 0.87
   4 !   11.1   8.5   0.00026      0.39       6      32 .]     481     507 ..     472     507 .. 0.86
   5 !   18.3   7.8   1.5e-06    0.0023       6      32 .]     521     546 ..     516     546 .. 0.92
   6 !    7.3  10.4     0.004         6       4      32 .]     557     585 ..     551     585 .. 0.84
   7 !   18.2   7.0   1.6e-06    0.0024       6      32 .]     599     624 ..     594     624 .. 0.91
   8 !   17.1  10.5   3.5e-06    0.0052       5      32 .]     637     663 ..     633     663 .. 0.91
   9 !    8.0   8.3    0.0025       3.7       6      32 .]     677     702 ..     672     702 .. 0.87
  10 !   18.5   6.8   1.3e-06     0.002       7      32 .]     717     741 ..     712     741 .. 0.93
  11 !   20.5   6.8   3.2e-07   0.00047       5      32 .]     754     780 ..     749     780 .. 0.91
  12 !   19.4   8.2   6.7e-07     0.001       4      32 .]     791     819 ..     785     819 .. 0.89
  13 !   19.8   7.7   5.2e-07   0.00077       5      32 .]     832     858 ..     826     858 .. 0.91
  14 !    6.6  11.0    0.0068        10       4      32 .]     869     897 ..     863     897 .. 0.84
  15 !   18.5   6.8   1.3e-06     0.002       7      32 .]     912     936 ..     907     936 .. 0.93
  16 !   14.4   9.3   2.4e-05     0.036       5      32 .]     949     975 ..     945     975 .. 0.89
  17 !   12.7   8.4   8.2e-05      0.12       7      32 .]     984    1010 ..     978    1010 .. 0.83
  18 !   13.0   7.8   6.6e-05     0.099       5      32 .]    1023    1049 ..    1015    1049 .. 0.90
  19 ?    5.4  12.6     0.016        24       1      32 []    1054    1085 ..    1054    1085 .. 0.90
  20 !   18.0  10.1   1.9e-06    0.0028       6      32 .]    1099    1124 ..    1097    1124 .. 0.88
  21 !   14.8   9.7   1.9e-05     0.029       3      32 .]    1135    1163 ..    1134    1163 .. 0.91
  22 !   18.3   8.2   1.5e-06    0.0023       5      32 .]    1176    1202 ..    1170    1202 .. 0.91

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0073
       EGF_2   5 deiCgghGtCvnqcGqCdC..dsgyqGktC 32 
                 ++ C+g+G+C n+   C C  +s + G  C
  EFC38984.1 359 GDVCSGRGVCLNFD-ICNCfnSSLWGGEFC 387
                 789********999.9***54444557777 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.003
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyq..GktC 32 
                  + C+g GtCv ++ +C+C ++ +  G +C
  EFC38984.1 400 TSVCSGIGTCVYAN-NCSCWNSTFwgGQNC 428
                 678********777.8***55544447777 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00053
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +  G+C C   y G +C
  EFC38984.1 442 SVCSGNGNCLA-PGVCNCTEMYGGSNC 467
                 57*******84.56***********99 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00026
       EGF_2   6 eiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 e C+   G Cv+++ +C+C+ gy+G +C
  EFC38984.1 481 EVCSYsKGRCVSPN-NCSCSEGYHGSNC 507
                 5677779****999.8************ PP

  == domain 5  score: 18.3 bits;  conditional E-value: 1.5e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g G+C +++ +C C++g++G +C
  EFC38984.1 521 NVCSGKGVCLSLN-NCTCQQGFYGEKC 546
                 67*******9899.8************ PP

  == domain 6  score: 7.3 bits;  conditional E-value: 0.004
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ hG C n    C C   y+G +C
  EFC38984.1 557 DkKDVCSSHGNCSNID-TCNCTKPYYGTNC 585
                 36789*******8555.8************ PP

  == domain 7  score: 18.2 bits;  conditional E-value: 1.6e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ +G C ++  +C C+ gy+Gk C
  EFC38984.1 599 SVCSSRGFCSSLD-NCTCQEGYYGKEC 624
                 68********999.8************ PP

  == domain 8  score: 17.1 bits;  conditional E-value: 3.5e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+Cv+++ +C C++g++G +C
  EFC38984.1 637 STVCSGKGSCVSAN-NCTCQQGFYGSNC 663
                 578********999.8************ PP

  == domain 9  score: 8.0 bits;  conditional E-value: 0.0025
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG C n    C C   y+G +C
  EFC38984.1 677 DVCSSHGNCTNID-TCNCTKPYYGQNC 702
                 57*******8555.8***********9 PP

  == domain 10  score: 18.5 bits;  conditional E-value: 1.3e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ +G+C ++  +C C+ gy+Gk C
  EFC38984.1 717 VCSSRGICSSLD-NCTCQEGYYGKEC 741
                 7********999.8************ PP

  == domain 11  score: 20.5 bits;  conditional E-value: 3.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+Cv+++ +C C++g++G  C
  EFC38984.1 754 STVCSGKGVCVSLN-NCTCQQGFYGERC 780
                 578********999.8***********9 PP

  == domain 12  score: 19.4 bits;  conditional E-value: 6.7e-07
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ +G+C ++  +C C+ gy+Gk C
  EFC38984.1 791 DmGDVCSARGICSSLD-NCTCKEGYYGKEC 819
                 47899********999.8************ PP

  == domain 13  score: 19.8 bits;  conditional E-value: 5.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+C +++ +C+C++g++G +C
  EFC38984.1 832 SNVCSGKGVCLSLN-NCSCQQGFYGESC 858
                 689*******9899.8***********9 PP

  == domain 14  score: 6.6 bits;  conditional E-value: 0.0068
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ C+ hG C n    C C   y+G +C
  EFC38984.1 869 DkKDVCSSHGNCSNID-TCNCTKPYYGQNC 897
                 36789*******8555.8***********9 PP

  == domain 15  score: 18.5 bits;  conditional E-value: 1.3e-06
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ +G+C ++  +C C+ gy+Gk C
  EFC38984.1 912 VCSSRGICSSLD-NCTCQEGYYGKEC 936
                 7********999.8************ PP

  == domain 16  score: 14.4 bits;  conditional E-value: 2.4e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghG C ++   C C+s+++G +C
  EFC38984.1 949 STVCSGHGNCTDKD-TCACKSSHYGYNC 975
                 578*******9888.8*********999 PP

  == domain 17  score: 12.7 bits;  conditional E-value: 8.2e-05
       EGF_2    7 iCgghGtCvnqcGq..CdCdsgyqGktC 32  
                  +C  +GtC n++G   C+Cdsgy G  C
  EFC38984.1  984 QCV-NGTCLNETGIaiCKCDSGYGGSLC 1010
                  574.7****9***555**********99 PP

  == domain 18  score: 13.0 bits;  conditional E-value: 6.6e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+  GtC ++  +C+C+ gy+G +C
  EFC38984.1 1023 QSVCSASGTCQSPD-VCECQLGYFGLDC 1049
                  789********999.************9 PP

  == domain 19  score: 5.4 bits;  conditional E-value: 0.016
       EGF_2    1 Csas.deiCgghGtCvnqc.GqCdCdsgyqGktC 32  
                  Cs   ++iC+++ +C   + G C C+  + G++C
  EFC38984.1 1054 CSRVnKSICQNGYQCL--TsGTCTCSEEWGGDKC 1085
                  7777899********9..448************* PP

  == domain 20  score: 18.0 bits;  conditional E-value: 1.9e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ghG+C + + +C C++g+ G  C
  EFC38984.1 1099 NVCSGHGKCSSYN-NCTCNNGWNGLEC 1124
                  57*******9555.8*********999 PP

  == domain 21  score: 14.8 bits;  conditional E-value: 1.9e-05
       EGF_2    3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++++ C+g G+C ++  +C+C++g++G +C
  EFC38984.1 1135 NNESVCSGKGKCLKPD-ECSCKTGFTGGNC 1163
                  45889********999.9*********999 PP

  == domain 22  score: 18.3 bits;  conditional E-value: 1.5e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C +++ +C+C  g+ G+ C
  EFC38984.1 1176 SNVCSGNGQCKSPN-NCECLKGFVGNEC 1202
                  689********999.8************ PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.2   4.1   3.1e-34   4.6e-31       4     263 ..    2269    2512 ..    2266    2513 .. 0.86

  Alignments for each domain:
  == domain 1  score: 108.2 bits;  conditional E-value: 3.1e-34
                  EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHHHHSS--HH CS
     Pkinase    4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladllerkgslsee 98  
                  + ++G+G   +V+k++++ +++  A+K++k +++++ ++  +l+    l ++  pni+++ e+f +  ++++++ ++y e g++ +l +r+ ++se+
  EFC38984.1 2269 IARIGSG---NVFKVIDSVKNCSKAIKIVKYKSEEDVNK--FLNQAVHLLNTTNPNICKINEIFVStiDQKICIDMDYFEMGDFSKLTNRNFNVSEK 2360
                  5566665...6888888889************9999886..8998888999999**********99999**************************** PP

                  HHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEE.TTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHH CS
     Pkinase   99 eakkiakqilegleylH.skgiiHrDlKpeNiLid.ekge....lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilye 189 
                   +k+i+ qi++gley H  +++iH  +K +N+Li+  + +      i+DFG     ++        + + + +PE+++  ++  ++D++slGv++y+
  EFC38984.1 2361 LVKQIIFQICTGLEYSHcVEKCIHANIKHSNLLIKsLD-NdnihALISDFGYGVFGTK--------VNPIFSSPEIVSVYKHYFNADIFSLGVVMYQ 2448
                  *****************7789*************9423.2356789******988777........5699*******999999************** PP

                  HHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGG CS
     Pkinase  190 lltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpy 263 
                  ++t+    s    +e  + + d+ ++++++l++        +  s+e++dl+ ++l+kd+ +R+ a+++l+h+ 
  EFC38984.1 2449 IMTKDITTS---ISE-LYGHRDE-KEVVQMLRK-----TLVERYSNEIIDLVLSMLEKDNLTRPQAQDVLSHSL 2512
                  *****9999...333.3444444.355555544.....577889****************************86 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.0   1.2e-08   1.7e-05       1      26 [.      36      61 ..      36      63 .. 0.95
   2 !   16.6   0.0   3.8e-06    0.0057       1      23 [.      92     114 ..      92     117 .. 0.93
   3 ?    3.3   0.0     0.064        96       1      28 []     149     176 ..     149     176 .. 0.91
   4 !   19.2   0.2   5.7e-07   0.00086       4      27 ..     247     270 ..     244     271 .. 0.91
   5 !   12.0   0.1   0.00011      0.17       6      27 ..     308     329 ..     308     330 .. 0.93

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 1.2e-08
                BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvq 26
                fn+P+G+av +n++++++Ds+nh v+
  EFC38984.1 36 FNSPEGIAVGNNNELFISDSKNHLVK 61
                99*********************997 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 3.8e-06
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +nyP G++v+s G +++aD+ nh
  EFC38984.1  92 LNYPGGICVTSEGKLLIADTLNH 114
                 79*****************9888 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.064
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 +n+P  v+ ++nG+iy +Ds n rv+++
  EFC38984.1 149 LNQPKYVTSLPNGNIYFSDSLNYRVRKY 176
                 6888889999***************987 PP

  == domain 4  score: 19.2 bits;  conditional E-value: 5.7e-07
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P+Gva+ +n d+y+aD++nh v+v
  EFC38984.1 247 PTGVAYGPNKDLYIADRGNHVVRV 270
                 9*******************7776 PP

  == domain 5  score: 12.0 bits;  conditional E-value: 0.00011
                 EEEEETTTEEEEEECCCTEEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvqv 27 
                 +v v+s G+i++ D++n r+++
  EFC38984.1 308 DVDVSSEGHIFILDTGNLRIRK 329
                 699*****************87 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.3   0.9   2.8e-20   4.2e-17      11     256 ..    2276    2508 ..    2263    2511 .. 0.84

  Alignments for each domain:
  == domain 1  score: 62.3 bits;  conditional E-value: 2.8e-20
                   SSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHH CS
  Pkinase_Tyr   11 afGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct..keepllivteyvkgGdLlkfLrkkekekltlkd 104 
                   +  kV+       ++ k+++ a+K++k +++e+  +++l++a  + ++ +pni k+  + +   +++++i ++y + Gd++k  +++   +++ k 
   EFC38984.1 2276 NVFKVI-------DSVKNCSKAIKIVKYKSEED-VNKFLNQAVHLLNTTNPNICKINEIFVstIDQKICIDMDYFEMGDFSKLTNRN--FNVSEKL 2361
                   333333.......34556888*****8877777.99******************9998877558899*************9877666..8999999 PP

                   HHHHHHHHHHHHHHHHH.TTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHH CS
  Pkinase_Tyr  105 llsfalqvAkGmeyLes.kklvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvll 195 
                   + ++++q++ G+ey +  +k++H ++   N L+++    n ++ isDfG               ++k++  + +pE+++  k   ++D++s Gv++
   EFC38984.1 2362 VKQIIFQICTGLEYSHCvEKCIHANIKHSNLLIKSldndNIHALISDFGYGVF-----------GTKVNPIFSSPEIVSVYKHYFNADIFSLGVVM 2446
                   99************996267*************98777677899****96554...........47888889************************ PP

                   HHHHTTS.SGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr  196 wEiftlg.espypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselv 256 
                   + i+t+   +++++l  ++  + + +  r +  e  ++e+ +l+ + +e+d   Rp+ ++++
   EFC38984.1 2447 YQIMTKDiTTSISELYGHRDEKEVVQMLRKTLVERYSNEIIDLVLSMLEKDNLTRPQAQDVL 2508
                   ****964156677777777778888888888899999*******************999886 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.2     1e-06    0.0015      30     106 ..    2148    2234 ..    2136    2241 .. 0.66

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1e-06
     TMEM154   30 teseslkqeeakeslssaelsnesdqlelvlmiiiPlvllillllvviiliqkkkrkrsKddekseaesd..........eldsenv 106 
                  ++++s + +e  ++ +  + ++  d  +l   i++P   +++l+++++i+  ++  +r K ++     ++          el ++n+
  EFC38984.1 2148 VTEPSSPISELSNNRNPDNAQQGMDTGALAAAIAVPVAFVVILIIIIVIILLICIVWRMKKKQPRTETLSnvatinsgdiELVYDNL 2234
                  446666666677777777788888888889999***988887777777666677777776664433333334655666555556665 PP

>> Syndecan  Syndecan domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   1.1   1.3e-05      0.02      11      37 ..    2181    2209 ..    2172    2218 .. 0.66

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.3e-05
    Syndecan   11 aviggvvvgllfaillvlf..lvYRmrKK 37  
                  av ++ vv+l+++i+++l+  +v+Rm+KK
  EFC38984.1 2181 AVPVAFVVILIIIIVIILLicIVWRMKKK 2209
                  33345666666655555542279*****9 PP

>> MA3  MA3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.4   7.8e-05      0.12       2      63 ..    2451    2511 ..    2450    2520 .] 0.89

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 7.8e-05
                  HHHHHHHHHSSS...SHHHHHHHHHHTT--TTHHHHHHHHHHHHHHS.SS--HHHHHHHHHH CS
         MA3    2 rrkifliieeylssgdyeeavsklekLklpkqeheivkillecaleesktyneyyglllekl 63  
                   ++i+++i e + ++d +e+v+ l+k  ++ + +ei++ +l+++ ++ + +++ +  +l++ 
  EFC38984.1 2451 TKDITTSISELYGHRDEKEVVQMLRKTLVERYSNEIIDLVLSMLEKD-NLTRPQAQDVLSHS 2511
                  5899**************************************99888.99999888888775 PP

>> DUF5385  Family of unknown function (DUF5385)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   1.7   7.8e-05      0.12       5      36 ..    2186    2217 ..    2184    2231 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 7.8e-05
     DUF5385    5 fliiliiiiiiilvivfllrkkkkqkeeekag 36  
                  f++iliiii+iil+i  ++r kkkq ++e+ +
  EFC38984.1 2186 FVVILIIIIVIILLICIVWRMKKKQPRTETLS 2217
                  77888888888888877777777777766554 PP

>> TMEM51  Transmembrane protein 51
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00014      0.21      31      94 ..    2148    2215 ..    2139    2233 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00014
      TMEM51   31 eseadkpkasanssskpdkdsgkeek....ksktssvAyVLvGaGvalLlLsicLgirdkkrarqeee 94  
                   +e ++p ++ +++ +pd+ +++ +        +  vA+V++   +++++L ic+  r kk++ ++e+
  EFC38984.1 2148 VTEPSSPISELSNNRNPDNAQQGMDTgalaAAIAVPVAFVVILIIIIVIILLICIVWRMKKKQPRTET 2215
                  445566766666666666665555544454678899************************99986654 PP

>> DUF4381  Domain of unknown function (DUF4381)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   0.00016      0.23      16      59 ..    2183    2223 ..    2175    2240 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00016
     DUF4381   16 PpapGwwlllaalllllllvlalwllrrrkrnrreAlreLaalr 59  
                  P a    ++l+++++++ll+ ++w++++++  r e l+ +a+++
  EFC38984.1 2183 PVAFV--VILIIIIVIILLICIVWRMKKKQP-RTETLSNVATIN 2223
                  55554..444457779999999**9988875.*****9999998 PP

>> Orthoreo_P17  Orthoreovirus P17 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.2     0.003       4.4      20      85 ..    1706    1771 ..    1690    1794 .. 0.89
   2 ?    2.1   0.0      0.12   1.8e+02      17      58 ..    2095    2136 ..    2087    2139 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.003
  Orthoreo_P17   20 vlrelltpsvtaivardsvkyinielplsHpklsvlsallsdpvvvHvkLirRfaldstlssiCey 85  
                    + +e+l ++ ++ + +ds+  i +e++++  +l+vls+ l++++v H    +  +l  +++ i e+
    EFC38984.1 1706 IAHETLVSISCLTLPQDSISSIVMEVHSQNERLFVLSNSLKNTIVTHLPFFNQQSLVLVVKMINEF 1771
                    55778888999999************************************9999998888888777 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.12
  Orthoreo_P17   17 spivlrelltpsvtaivardsvkyinielplsHpklsvlsal 58  
                    s+ + ++++++svt+  ++    y+++e + sH  l+++ +l
    EFC38984.1 2095 SKSWSQSGISSSVTITKRNGDLLYFDLECQVSHLSLFTIQEL 2136
                    5679999**************************999988765 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   3.9       1.6   2.3e+03       5      24 ..     360     376 ..     351     385 .. 0.78
   2 ?    0.7   4.2      0.45   6.7e+02       5      30 ..     441     464 ..     438     466 .. 0.82
   3 ?    7.3   1.5    0.0039       5.9      10      32 .]     488     506 ..     485     506 .. 0.87
   4 ?    8.0   3.4    0.0023       3.5       5      31 ..     521     544 ..     517     545 .. 0.87
   5 ?    1.7   6.5      0.22   3.3e+02       5      31 ..     559     583 ..     551     584 .. 0.82
   6 ?   12.8   2.3   7.7e-05      0.11       6      31 ..     601     622 ..     595     623 .. 0.88
   7 ?    6.6   4.3    0.0065       9.7       5      32 .]     638     662 ..     633     662 .. 0.84
   8 ?    3.9   4.8     0.046        68       6      31 ..     679     700 ..     673     701 .. 0.87
   9 ?   13.1   1.7   5.9e-05     0.088       6      31 ..     718     739 ..     712     740 .. 0.87
  10 ?   10.2   2.6   0.00049      0.73       5      32 .]     755     779 ..     750     779 .. 0.87
  11 ?   10.0   4.0   0.00055      0.83       5      31 ..     793     817 ..     785     818 .. 0.80
  12 ?    7.7   2.9     0.003       4.6       3      31 ..     832     856 ..     829     857 .. 0.90
  13 ?    2.0   6.5      0.18   2.7e+02       5      31 ..     871     895 ..     863     896 .. 0.82
  14 ?   13.1   1.7   5.9e-05     0.088       6      31 ..     913     934 ..     907     935 .. 0.87
  15 ?    0.9   4.1       0.4     6e+02       5      26 ..     950     968 ..     945     972 .. 0.78
  16 ?    3.9   8.4     0.047        70       4      31 ..     979    1008 ..     975    1009 .. 0.82
  17 ?   10.8   1.0   0.00031      0.46       4      30 ..    1022    1046 ..    1019    1048 .. 0.82
  18 ?    7.0   5.9    0.0047       7.1       1      31 [.    1054    1083 ..    1054    1084 .. 0.88
  19 ?    6.0   5.5      0.01        15       5      30 ..    1098    1121 ..    1095    1123 .. 0.86
  20 ?   10.3   3.1   0.00045      0.67       4      30 ..    1135    1160 ..    1132    1162 .. 0.88
  21 ?    5.8   5.4     0.011        17       3      31 ..    1176    1200 ..    1175    1201 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.6
                 T.STTT-EEEEETTTEEEEEE CS
         EGF   5 p.CsngGtCvdtgrggytCiC 24 
                   Cs++G C++      +C C
  EFC38984.1 360 DvCSGRGVCLNFD----ICNC 376
                 26*******7777....9999 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.45
                 T..STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytG 30 
                 p  Cs++G C+ +g     C C+e y G
  EFC38984.1 441 PsvCSGNGNCLAPG----VCNCTEMYGG 464
                 566*******9999....****986666 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0039
                 -EEEEETTTEEEEEECTTEESTT CS
         EGF  10 GtCvdtgrggytCiCpeGytGkr 32 
                 G+Cv++     +C C+eGy+G++
  EFC38984.1 488 GRCVSPN----NCSCSEGYHGSN 506
                 6798888....9*********86 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0023
                 T.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGk 31 
                 + Cs+ G C+++     +C+C++G+ G+
  EFC38984.1 521 NvCSGKGVCLSLN----NCTCQQGFYGE 544
                 45*******9999....*********98 PP

  == domain 5  score: 1.7 bits;  conditional E-value: 0.22
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +  Cs +G C +      tC C+ +y G 
  EFC38984.1 559 KdvCSSHGNCSNID----TCNCTKPYYGT 583
                 156*******9999....********995 PP

  == domain 6  score: 12.8 bits;  conditional E-value: 7.7e-05
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G+C ++     +C+C+eGy Gk
  EFC38984.1 601 CSSRGFCSSLD----NCTCQEGYYGK 622
                 *******5555....**********8 PP

  == domain 7  score: 6.6 bits;  conditional E-value: 0.0065
                 T.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 + Cs+ G Cv+      +C+C++G+ G++
  EFC38984.1 638 TvCSGKGSCVSAN----NCTCQQGFYGSN 662
                 25*******9999....*********986 PP

  == domain 8  score: 3.9 bits;  conditional E-value: 0.046
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G C +      tC C+ +y G 
  EFC38984.1 679 CSSHGNCTNID----TCNCTKPYYGQ 700
                 ***********....********996 PP

  == domain 9  score: 13.1 bits;  conditional E-value: 5.9e-05
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G+C ++     +C+C+eGy Gk
  EFC38984.1 718 CSSRGICSSLD----NCTCQEGYYGK 739
                 *******5555....**********8 PP

  == domain 10  score: 10.2 bits;  conditional E-value: 0.00049
                 T.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 + Cs+ G Cv++     +C+C++G+ G+r
  EFC38984.1 755 TvCSGKGVCVSLN----NCTCQQGFYGER 779
                 24***********....**********97 PP

  == domain 11  score: 10.0 bits;  conditional E-value: 0.00055
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                    Cs +G+C ++     +C+C+eGy Gk
  EFC38984.1 793 GdvCSARGICSSLD----NCTCKEGYYGK 817
                 256*******5555....**********8 PP

  == domain 12  score: 7.7 bits;  conditional E-value: 0.003
                 STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 +n Cs+ G C+++     +C C++G+ G+
  EFC38984.1 832 SNVCSGKGVCLSLN----NCSCQQGFYGE 856
                 577*******9999....*********97 PP

  == domain 13  score: 2.0 bits;  conditional E-value: 0.18
                 T..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytGk 31 
                 +  Cs +G C +      tC C+ +y G 
  EFC38984.1 871 KdvCSSHGNCSNID----TCNCTKPYYGQ 895
                 156*******9999....********996 PP

  == domain 14  score: 13.1 bits;  conditional E-value: 5.9e-05
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs +G+C ++     +C+C+eGy Gk
  EFC38984.1 913 CSSRGICSSLD----NCTCQEGYYGK 934
                 *******5555....**********8 PP

  == domain 15  score: 0.9 bits;  conditional E-value: 0.4
                 T.STTT-EEEEETTTEEEEEECT CS
         EGF   5 p.CsngGtCvdtgrggytCiCpe 26 
                 + Cs++G C d      tC C++
  EFC38984.1 950 TvCSGHGNCTDKD----TCACKS 968
                 25*******8888....****85 PP

  == domain 16  score: 3.9 bits;  conditional E-value: 0.047
                  TT....STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np....CsngGtCvdtgrggytCiCpeGytGk 31  
                  np    C  +GtC++   g  +C+C++Gy G+
  EFC38984.1  979 NPctlqC-VNGTCLNET-GIAICKCDSGYGGS 1008
                  6666779.6779*9999.***********996 PP

  == domain 17  score: 10.8 bits;  conditional E-value: 0.00031
                  TT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF    4 np..CsngGtCvdtgrggytCiCpeGytG 30  
                  n   Cs  GtC ++      C+C+ Gy+G
  EFC38984.1 1022 NQsvCSASGTCQSPD----VCECQLGYFG 1046
                  4577*******7777....*********9 PP

  == domain 18  score: 7.0 bits;  conditional E-value: 0.0047
                  GCS.TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    1 Csp.np..CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs  n+  C+ng  C+++g    tC+C+e + G+
  EFC38984.1 1054 CSRvNKsiCQNGYQCLTSG----TCTCSEEWGGD 1083
                  88878899*******7777....******99996 PP

  == domain 19  score: 6.0 bits;  conditional E-value: 0.01
                  T..STTT-EEEEETTTEEEEEECTTEES CS
         EGF    5 p..CsngGtCvdtgrggytCiCpeGytG 30  
                  p  Cs++G+C ++     +C+C +G+ G
  EFC38984.1 1098 PnvCSGHGKCSSYN----NCTCNNGWNG 1121
                  445*******8888....9*******99 PP

  == domain 20  score: 10.3 bits;  conditional E-value: 0.00045
                  TT...STTT-EEEEETTTEEEEEECTTEES CS
         EGF    4 np...CsngGtCvdtgrggytCiCpeGytG 30  
                  n+   Cs+ G+C+ +     +C C++G+tG
  EFC38984.1 1135 NNesvCSGKGKCLKPD----ECSCKTGFTG 1160
                  66688*******8888....*********9 PP

  == domain 21  score: 5.8 bits;  conditional E-value: 0.011
                  STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGk 31  
                  +n Cs++G C ++     +C+C  G+ G+
  EFC38984.1 1176 SNVCSGNGQCKSPN----NCECLKGFVGN 1200
                  567*******8888....********996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2520 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1271  (0.0708907); expected 358.6 (0.02)
Passed bias filter:                      615  (0.034302); expected 358.6 (0.02)
Passed Vit filter:                       117  (0.00652574); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 1.63u 0.35s 00:00:01.98 Elapsed: 00:00:00.58
# Mc/sec: 13075.59
//
Query:       EFC38985.1  [L=166]
Description: hypothetical protein NAEGRDRAFT_81432 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.77    9.9   6.2        1.7    8.8   2.4    2.2  2  DMPK_coil  DMPK coiled coil domain like


Domain annotation for each model (and alignments):
>> DMPK_coil  DMPK coiled coil domain like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.3    0.0017        31      17      56 ..      72     113 ..      69     114 .. 0.76
   2 ?    8.8   2.4   9.5e-05       1.7      29      58 ..     111     140 ..     104     143 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0017
   DMPK_coil  17 qeeLekvkaanlafes.kLkeaEkknre.LeeeleqLkkemE 56 
                 ++e + v +  + + + kL  +E  +++ L+e++  L k+ E
  EFC38985.1  72 SDETQGVIELTIGTKClKLEKTEITSQDfLQEQVYLLEKKFE 113
                 566666666677777769*********966778888888877 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 9.5e-05
   DMPK_coil  29 afeskLkeaEkknreLeeeleqLkkemEel 58 
                 +fe+ Lke   k + L++e+++L+   Eel
  EFC38985.1 111 KFERMLKENDNKIKSLNDEVNSLRAMNEEL 140
                 79**********************998886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1591  (0.0887389); expected 358.6 (0.02)
Passed bias filter:                      752  (0.0419432); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1050.05
//
Query:       EFC38986.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.17   12.6   2.2        2.5    8.8   0.2    2.9  3  DUF4864       Domain of unknown function (DUF4864)
       0.64    9.2  10.5       0.51    9.5   0.4    2.9  3  tRNA-synt_2e  Glycyl-tRNA synthetase alpha subunit


Domain annotation for each model (and alignments):
>> DUF4864  Domain of unknown function (DUF4864)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.032   2.9e+02      15      36 ..      39      60 ..      34      74 .. 0.69
   2 ?    8.8   0.2   0.00028       2.5      28      78 ..      72     122 ..      61     135 .. 0.85
   3 ?   -0.2   0.1      0.18   1.6e+03      45      61 ..     139     155 ..     128     175 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.032
     DUF4864 15 ddaakAysfAspgirakfgtae 36
                + ++  y+f+s++i++ + ++ 
  EFC38986.1 39 KSIKVKYHFTSQNIKEVVDKVI 60
                556677**********997654 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00028
     DUF4864  28 irakfgtaerFlemVrqaYpavyrprsvaflkletkeggvvqevlivdsdg 78 
                 i ++  + e F +m ++ +  +++ ++ +f+k+ +k+++++ +  i+ ++g
  EFC38986.1  72 IVETYYDDEYFTNMKQNTWIKIVNTSNTKFKKISKKQASIIESNHIKYEEG 122
                 556667999*****************************9999888877665 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.18
     DUF4864  45 aYpavyrprsvaflkle 61 
                  Y+ +y++++++f+  +
  EFC38986.1 139 VYRSIYQKENIQFTYDT 155
                 48999999999998654 PP

>> tRNA-synt_2e  Glycyl-tRNA synthetase alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   1.8     0.004        36     132     229 ..      20     119 ..      14     133 .. 0.65
   2 ?    9.5   0.4   5.7e-05      0.51     181     238 ..     138     195 ..     129     206 .. 0.92
   3 ?    2.3   0.1    0.0093        83     170     220 ..     196     249 ..     193     257 .. 0.69

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.004
                   CEEEEEEEEEEETTEE-SS--EEEEEEHHHHHHHHCT-SSGGG-ECCTTEEHHHH..HHHHHH.HHHHHHHCTS-HHHHHHHHHHHHHHHHHHHCCT CS
  tRNA-synt_2e 132 meitqftYfqqvgglelkpvsveityGleRlamylqevdnvydlewnekvtygdv..flqnev.eqsaynfeeadvelllklfeeyekeakrllekk 225
                   m i +f Yf   g ++l+  s+ + y       + + vd+v+dl ++   ty+ v  ++++e+  + + n     v++  + f++++k+ ++++e++
    EFC38986.1  20 MLIHKFPYFLLSGKTSLTDKSIKVKYHFTSQ-NIKEVVDKVIDLGFAFVETYKIVetYYDDEYfTNMKQNTWIKIVNTSNTKFKKISKKQASIIESN 115
                   7788999999999999999999999987643.33455799999988776666655114444431223333444455666677777777777777766 PP

                   -HHH CS
  tRNA-synt_2e 226 lvlp 229
                    +  
    EFC38986.1 116 HIKY 119
                   5554 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 5.7e-05
                   EEHHHHHHHHHHHHHHHHHCTS-HHHHHHHHHHHHHHHHHHHCCT-HHHHHHHHHHHH CS
  tRNA-synt_2e 181 vtygdvflqneveqsaynfeeadvelllklfeeyekeakrllekklvlpaydlvlkas 238
                   v y+ ++++++++++  ++e+++ ++++ + +   +e++++++++l  p +++++k+ 
    EFC38986.1 138 VVYRSIYQKENIQFTYDTVEYQEHKFVVFCISGNVSESSATVDDNLHDPVFEVCMKSR 195
                   68*****************************************************974 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.0093
                   SSGGG-ECCTTEEHHHHHHHH....HHHHHHHHHCTS-HHHHHHHHHHHHHHHHH CS
  tRNA-synt_2e 170 dnvydlewnekvtygdvflqn....eveqsaynfeeadvelllklfeeyekeakr 220
                   ++++++ w+++ +  ++ ++n    + e+s++nfe   ++   + f+e++k++ r
    EFC38986.1 196 SKIIEIIWRTNKELYKILQENnvipDLEYSSFNFEPL-IDRNSSSFNEMKKRVPR 249
                   6799999988766666666652333569******975.66677778877776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1373  (0.0765798); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 1568.25
//
Query:       EFC38987.1  [L=188]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (188 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       339  (0.0189079); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.28s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1180.70
//
Query:       EFC38988.1  [L=114]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-31  108.1   3.8    2.5e-14   52.7   0.1    3.1  3  DUF4116     Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.028   15.0   0.2       0.32   11.6   0.0    2.1  2  CbiG_C      Cobalamin synthesis G C-terminus
      0.039   13.1   0.4      0.042   13.0   0.4    1.0  1  Pox_C4_C10  Poxvirus C4/C10 protein
      0.039   14.0   0.7       0.14   12.1   0.6    1.8  1  Swm2        Nucleolar protein Swm2
       0.08   13.0   0.4       0.27   11.3   0.3    1.9  2  Bac_DnaA_C  Bacterial dnaA protein helix-turn-helix


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.1   1.4e-13   4.9e-10      15      49 .]       3      37 ..       2      37 .. 0.97
   2 !   52.7   0.1   6.9e-18   2.5e-14       1      49 []      39      88 ..      39      88 .. 0.96
   3 !   27.9   0.1   4.1e-10   1.5e-06      16      35 ..      80      99 ..      77     107 .. 0.86

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 1.4e-13
     DUF4116 15 alkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                a++++s e+kn++e+v++ vk++g  ++yas+ Lr
  EFC38988.1  3 AFEFASIEIKNNRELVMELVKKCGWMFEYASKQLR 37
                89*******************************98 PP

  == domain 2  score: 52.7 bits;  conditional E-value: 6.9e-18
     DUF4116  1 DrEivleavkkngs.alkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                DrEiv+ea+ ++   ++k++s+eL+nD+++++ A+k++ + l yasee+r
  EFC38988.1 39 DREIVTEAINRHADiVYKHVSKELRNDRQLAMIAIKNHASLLAYASEEIR 88
                9***********645*********************************98 PP

  == domain 3  score: 27.9 bits;  conditional E-value: 4.1e-10
     DUF4116 16 lkylseeLknDkeivlkAvk 35
                l y+see++nDkeiv++A+k
  EFC38988.1 80 LAYASEEIRNDKEIVMEAIK 99
                77*****************9 PP

>> CbiG_C  Cobalamin synthesis G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   8.8e-05      0.32      36      66 ..       5      35 ..       2      59 .. 0.84
   2 ?    2.2   0.1     0.072   2.6e+02      28      43 ..      67      88 ..      38     109 .. 0.50

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.8e-05
                EEEESSCCSHHHHHHHHHHHCTSTEEEE-HH CS
      CbiG_C 36 alatidlKadepgllelaeklglplktfsae 66
                ++a+i++K++ + ++el++k+g+ +++ s++
  EFC38988.1  5 EFASIEIKNNRELVMELVKKCGWMFEYASKQ 35
                68*********************99977664 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.072
                T--GGGEEE......EEESSCC CS
      CbiG_C 28 glseeavaa......latidlK 43
                +l++ a+++       a+ +++
  EFC38988.1 67 QLAMIAIKNhasllaYASEEIR 88
                3333333321111113344444 PP

>> Pox_C4_C10  Poxvirus C4/C10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.4   1.2e-05     0.042       7      80 ..       6      87 ..       3     113 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
  Pox_C4_C10  7 FaddeFdsikkellellkv..vdlndkskqivlenslnkdlveklknliydqlknvvs......evevenkvtlvkyekgdy 80
                Fa  e ++ ++ ++el+k   + +++ skq++ + ++ ++ ++   +++y+++++ ++       + ++n+ +l+ y   + 
  EFC38988.1  6 FASIEIKNNRELVMELVKKcgWMFEYASKQLRGDREIVTEAINRHADIVYKHVSKELRndrqlaMIAIKNHASLLAYASEEI 87
                66667777788888888872245578***************************99888888888999******999987743 PP

>> Swm2  Nucleolar protein Swm2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.6     4e-05      0.14      24      96 ..      10      84 ..       4     106 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4e-05
        Swm2 24 aiakdeelkkkalkkCkevfekweek...ddavdkevvkrcldlwlvlkgkeYklkeeeslsNliieevdvsevks 96
                +i++++el  + +kkC  +fe  +++   d ++ +e ++r  d+ +    ke +  +++ +   i++++ +  + s
  EFC38988.1 10 EIKNNRELVMELVKKCGWMFEYASKQlrgDREIVTEAINRHADIVYKHVSKELRN-DRQLAMIAIKNHASLLAYAS 84
                699*****************98776522255788899999999887777776666.55555556777777777755 PP

>> Bac_DnaA_C  Bacterial dnaA protein helix-turn-helix
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.35   1.3e+03      28      42 ..      11      25 ..       8      49 .. 0.72
   2 ?   11.3   0.3   7.5e-05      0.27      16      66 ..      50      98 ..      40     100 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.35
                SHHHHHHHHHHHHHT CS
  Bac_DnaA_C 28 iveaRqiamylarel 42
                i + R ++m l+++ 
  EFC38988.1 11 IKNNRELVMELVKKC 25
                667788888888865 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 7.5e-05
                HHHHHS----CSSHHHHHHHHHHHHHTS---HHHHHHHHT-STTHHHHHHH CS
  Bac_DnaA_C 16 vedlkskkRkkeiveaRqiamylareltdlslpeIGkefggrdHsTVihai 66
                 +d++ k  +ke+ + Rq+am  ++++  + l+   +e+ + d+  V+ ai
  EFC38988.1 50 HADIVYKHVSKELRNDRQLAMIAIKNHA-SLLAYASEEI-RNDKEIVMEAI 98
                68999999*****************995.4444445555.66766666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (114 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       797  (0.0444531); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 764.58
//
Query:       EFC38989.1  [L=743]
Description: hypothetical protein NAEGRDRAFT_81434 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.7e-15   55.9  50.7      3e-09   37.0  12.2    4.5  4  IBR           IBR domain, a half RING-finger domain
     0.0055   16.6   9.1     0.0055   16.6   9.1    4.3  3  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
  ------ inclusion threshold ------
      0.016   15.2   5.8      0.016   15.2   5.8    3.4  3  zf-RING_UBOX  RING-type zinc-finger
        7.5    6.1  14.8        7.5    6.1   0.5    4.4  3  zf-ribbon_3   zinc-ribbon domain


Domain annotation for each model (and alignments):
>> IBR  IBR domain, a half RING-finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   8.3      0.15   6.9e+02      38      56 ..     330     360 ..     312     364 .. 0.62
   2 ?    0.1   0.1      0.22   9.8e+02       5      30 ..     362     385 ..     358     388 .. 0.62
   3 !   31.6  10.5   3.2e-11   1.5e-07       2      62 .]     403     464 ..     401     464 .. 0.91
   4 !   37.0  12.2   6.7e-13     3e-09      15      58 ..     487     530 ..     478     534 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.15
         IBR  38 s...........vt.CskCgfefCfnCkkew 56 
                 +           +t  + Cg++fC  C k++
  EFC38989.1 330 NtcpacfcddvpMTeSPMCGHSFCNACWKSY 360
                 134444444555333788*********8765 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.22
         IBR   5 klklkkslesdpnlkwCprpdCeaii 30 
                 + k k++    +++++C   dC+a++
  EFC38989.1 362 EVKIKETSGLGQTRINCM--DCNAAL 385
                 555566555566777787..787765 PP

  == domain 3  score: 31.6 bits;  conditional E-value: 3.2e-11
         IBR   2 kyeklklkkslesdpnlkwCprpdCeaiiekseg..cksvtCskCgfefCfnCkkewHeglsC 62 
                 ++ + + +++++++  ++ Cp++ C+ +i+k+ +   ++v+C  Cg++fCf+C+ke H + +C
  EFC38989.1 403 RFIENRIETYVSDHFMVTRCPSNRCKCAIKKTIDepIHYVKCY-CGERFCFQCGKEPHFPSTC 464
                 5667778889999999*************9999987777****.******************9 PP

  == domain 4  score: 37.0 bits;  conditional E-value: 6.7e-13
         IBR  15 dpnlkwCprpdCeaiieksegcksvtCskCgfefCfnCkkew..He 58 
                 + n+k Cp  +C+++iek+ gc+++tCs C++efC+ C  +w  H+
  EFC38989.1 487 QGNTKVCP--NCKKAIEKNGGCNHMTCSMCRHEFCWLCFGKWstHN 530
                 468999**..********************************6554 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   9.1   1.2e-06    0.0055       1      41 []     332     381 ..     332     381 .. 0.89
   2 ?   -5.6   7.8         4   1.8e+04      15      26 ..     444     455 ..     425     464 .. 0.76
   3 ?    2.9  12.7     0.022        99       1      38 [.     493     534 ..     492     536 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.2e-06
                 -TTT-S--SS-E.E-TTS--B-CHHHHHHHHC.........TSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepnelleCkHsfCskCirkilks.........rkkvkCPlC 41 
                 Cp C++  +  +e+  C+HsfC++C +++l+          ++  +C+ C
  EFC38989.1 332 CPACFCDDVPMTESPMCGHSFCNACWKSYLEVkiketsglgQTRINCMDC 381
                 9*******999999****************98888888887777778888 PP

  == domain 2  score: -5.6 bits;  conditional E-value: 4
                 -TTS--B-CHHH CS
    zf-C3HC4  15 leCkHsfCskCi 26 
                   C+ +fC++C 
  EFC38989.1 444 CYCGERFCFQCG 455
                 569999*****6 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.022
                 -TTT-S--SS-E......E-TTS--B-CHHHHHHHHCTSSB-- CS
    zf-C3HC4   1 CpiCleeakepn.....elleCkHsfCskCirkilksrkkvkC 38 
                 Cp C++ ++++      + + C+H+fC  C  k+   ++ + C
  EFC38989.1 493 CPNCKKAIEKNGgcnhmTCSMCRHEFCWLCFGKWST-HNFEAC 534
                 899999988888999989999*********999988.766667 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   5.8   3.7e-06     0.016       1      30 [.     332     370 ..     332     379 .. 0.62
   2 ?   -5.3   4.1         4   1.8e+04      16      24 ..     446     454 ..     429     469 .. 0.68
   3 ?   -2.2   9.2      0.98   4.4e+03       1      26 [.     493     526 ..     493     539 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 3.7e-06
  zf-RING_UBOX   1 CpICl.e..lft.dPlvlpCGHtFCreCl....w....elsk 30 
                   Cp C+ +  ++t  P +  CGH+FC  C     +    e+s 
    EFC38989.1 332 CPACFcDdvPMTeSP-M--CGHSFCNACWksylEvkikETSG 370
                   9****5544444556.4..*********85443133445555 PP

  == domain 2  score: -5.3 bits;  conditional E-value: 4
  zf-RING_UBOX  16 CGHtFCreC 24 
                   CG  FC +C
    EFC38989.1 446 CGERFCFQC 454
                   777899999 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.98
  zf-RING_UBOX   1 CpIClelft.....dP...lvlpCGHtFCreCl..w 26 
                   Cp C+   +     +     +  C H FC+ C   w
    EFC38989.1 493 CPNCKKAIEknggcNHmtcSM--CRHEFCWLCFgkW 526
                   888888887666663322222..9999999998654 PP

>> zf-ribbon_3  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.7    0.0023        10      11      22 ..     324     335 ..     321     335 .. 0.81
   2 ?    0.7   1.4     0.087   3.9e+02      16      24 ..     448     456 ..     446     458 .. 0.73
   3 ?    6.1   0.5    0.0017       7.5       2      11 ..     490     500 ..     489     502 .. 0.76

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0023
  zf-ribbon_3  11 plssddnvCpyC 22 
                  +  +ddn+Cp C
   EFC38989.1 324 QTNDDDNTCPAC 335
                  5679******** PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.087
  zf-ribbon_3  16 dnvCpyCGt 24 
                   ++C  CG+
   EFC38989.1 448 ERFCFQCGK 456
                  578888886 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0017
  zf-ribbon_3   2 tvrCPnCGa.p 11 
                  t+ CPnC++ +
   EFC38989.1 490 TKVCPNCKKaI 500
                  78899999844 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (743 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2029  (0.113169); expected 358.6 (0.02)
Passed bias filter:                      327  (0.0182386); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.30s 00:00:01.05 Elapsed: 00:00:00.50
# Mc/sec: 4473.28
//
Query:       EFC38990.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.1e-40  136.9   0.1      1e-39  136.2   0.1    1.4  1  DUF2263   Uncharacterized protein conserved in bacteria (DUF2
  ------ inclusion threshold ------
      0.028   14.9   0.1      0.058   13.9   0.1    1.5  1  DUF1820   Domain of unknown function (DUF1820)


Domain annotation for each model (and alignments):
>> DUF2263  Uncharacterized protein conserved in bacteria (DUF2263)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  136.2   0.1   1.1e-43     1e-39       2     146 .]      84     254 ..      83     254 .. 0.92

  Alignments for each domain:
  == domain 1  score: 136.2 bits;  conditional E-value: 1.1e-43
                 HHHHHHHHHTEEE-TTS-EEE-HHH....HHHHHHT-EEE-H...............HHHHHHEEES--HHHHHHHHHHH-SS--EEEEE--SSSTTTT CS
     DUF2263   2 qetleilekgeylnskgekvdlrea....veaavkgtklysp.....kkaastseeeeeetkievteestleaarrlvkeegekvavLNfASaknpGGG 91 
                 ++t+  l++g+y+nsk+ekv++r+     +e++++++kly+      ++++sts++++ +t+iev++e+++e++ +l+k+ g++++vLN+AS+k++GGG
  EFC38990.1  84 KDTMLSLQRGFYYNSKKEKVSIRNLdkeiYEQQLAKNKLYQFneiekIVFNSTSTNQQFATTIEVIKEDCVETIFKLHKN-GMNPVVLNMASKKRAGGG 181
                 5899*******************988999***********558888899*****************************99.****************** PP

                 GGGT--SHHHHHHHHBSHHHHHTT-HHHHHHH...HHH-...............-TT--S-.EEEEEEEEEEE- CS
     DUF2263  92 flnGakAQEEsLarsSaLyasllkaeefYeah...rakr...............splysda.miYSpeVpvfrd 146
                 f++G+k+QEE+L+rs+++++sll++++++++    ++k+               +pl sd+ +iYSp+V+++r+
  EFC38990.1 182 FETGQKSQEEALFRSTNYIYSLLDPNDIFKKFnpnCKKPspdqqivsvigpdqfYPL-SDYdIIYSPNVQLLRH 254
                 ************************99999754444555489**********998888.5555**********96 PP

>> DUF1820  Domain of unknown function (DUF1820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   6.5e-06     0.058      15      42 ..     111     138 ..     102     156 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 6.5e-06
     DUF1820  15 elyarevsqselyGfieveelvfderss 42 
                 e+y +++ +++ly f e+e++vf+++s+
  EFC38990.1 111 EIYEQQLAKNKLYQFNEIEKIVFNSTST 138
                 8**********************98875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       976  (0.0544369); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.45
# Mc/sec: 2621.97
//
Query:       EFC38991.1  [L=802]
Description: TCCD-inducible-PARP-like domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-26   92.5   2.2    2.4e-26   92.5   2.2    2.6  2  PARP           Poly(ADP-ribose) polymerase catalytic domain
  ------ inclusion threshold ------
       0.52   10.8   0.0       0.52   10.8   0.0    4.5  6  IZUMO          Izumo sperm-egg fusion, Ig domain-associated
       0.87    8.8  14.0        4.4    6.5  13.5    2.4  2  ISG65-75       Invariant surface glycoprotein


Domain annotation for each model (and alignments):
>> PARP  Poly(ADP-ribose) polymerase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   3.1       1.6   9.6e+03       3      43 ..     476     517 ..     474     542 .. 0.62
   2 !   92.5   2.2     4e-30   2.4e-26      24     194 ..     611     800 ..     593     801 .. 0.77

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 1.6
                 HHHHHHHHHHHTS-TTTT.EEEEEEEEEEEEETTHHHHCGCC CS
        PARP   3 eykeiekylkktldstha.yklkileifrvqregeaerfqek 43 
                 ey++  ++lk +++++ha  + ki+e+++ +++   e+ +e+
  EFC38991.1 476 EYEQQLNNLKLNMTNEHAeLEQKIKELEQKKKQLSRESSKER 517
                 677777777777777777678888888873333333333333 PP

  == domain 2  score: 92.5 bits;  conditional E-value: 4e-30
                 EEEEEEEEEETTHHHHCGCCGG.....................................SS-EEEEEEEE-GGGHHHHHHH-S--S-TTS-GGGSTTSS CS
        PARP  24 kileifrvqregeaerfqekkk.....................................lrnrrlLfHGsrltnvasilsqGLriappeapvtGymfGk 85 
                  i  ++r++++++ + ++ +++                                      +n+++L+HG++ + v  i ++G+  + ++a++ G  fG 
  EFC38991.1 611 VISSVYRIENPSLYSAYKIRENhissyqdplnpiqvqtenfttlkspafewlkstglntSMNEKYLWHGTKHEYVNTISEHGF--DERVASLAG-LFGA 706
                 56666666666666666666666666666666666666666666556666666688888899*********************..*******66.7*** PP

                 SEEEBSSHHHHHGGG--BSSS-EEEEEEEEEE--SEEEESS--T.GCCGGTT-SEEEE-EEEEEGG.EEETTE--S-EEE-S--SSSEEE-EEEESSGG CS
        PARP  86 GiYfAddaskSanYcktsekkgsglllLaeValGdikeltkady.lekakkgkksvkgkgktepesivekdgvPlgkssatkyesseleyneyvvydke 183
                 G+YfA+  skS +Y+++ +++g+ +++L++V lG   +++   + ++ +++    ++g+ ++              +s+  +++ss+++y+e++vyd  
  EFC38991.1 707 GVYFAEYCSKSDQYSTP-DTNGEYYMFLCRVVLGR--QIYYTPMgMT-NQRRPPEINGSNRRVY------------DSVIGQSNSSNSSYREFIVYDRY 789
                 ****************9.99***************..6666666343.3334444555555555............3345566777799********** PP

                 GEEEEEEEEEE CS
        PARP 184 qvrlkYLlevk 194
                 q++++YL++++
  EFC38991.1 790 QCYPEYLIKYR 800
                 *********96 PP

>> IZUMO  Izumo sperm-egg fusion, Ig domain-associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.4       1.6   9.8e+03      28      49 ..      68      89 ..      48     111 .. 0.45
   2 ?   10.8   0.0   8.7e-05      0.52       4      80 ..     126     204 ..     125     215 .. 0.88
   3 ?   -2.7   0.0       1.3   7.9e+03      68     104 ..     243     280 ..     238     291 .. 0.68
   4 ?    1.3   7.6     0.078   4.6e+02      36     106 ..     435     505 ..     391     518 .. 0.80
   5 ?   -1.6  13.1      0.58   3.5e+03      16     109 ..     451     543 ..     438     554 .. 0.82
   6 ?    2.1   2.5     0.042   2.5e+02      24      81 ..     526     591 ..     513     605 .. 0.69

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.6
                HHHHHHHHHHHHHTTT---SGG CS
       IZUMO 28 reklleraealledlsekelae 49
                ++++ +++  +l +l+e+++++
  EFC38991.1 68 QHEITNQSFMELCSLNERVSKQ 89
                3333333333333333333222 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 8.7e-05
                 GGSHHHHHHHHHHHHTH.HHHHSGGHHHHHHHHHHHHHTTT..---SGGGGGGSEEEHHHHHHHHHHHHHHHHHHHHS-- CS
       IZUMO   4 qCdpkvvealksLeedl.lpselehreklleraealledls..ekelaenkflgvvdeetlekvasslkkelkrltdsdl 80 
                 +C++ + e+l +L  d+ + +++eh ++ll  + +++e+++  +  ++ n+++++++ e+lek+++++ + l++++ ++ 
  EFC38991.1 126 TCHNFINENLPNLVLDIgIREHIEHVNSLLYYIGSVVEAINldSYLINLNSYMQLLE-EKLEKLKEFIGNYLNEIYSQNN 204
                 59999999999999888578888***************999878999******9885.68***************98765 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.3
                 HHHHHHHHHHS---HHHHHH.HHHHHHHHHHHHHHHHH CS
       IZUMO  68 lkkelkrltdsdlkgelllk.eLlwllqkqkkklkeal 104
                 + k+l+++t s +    + + eL + l ++ ++l++  
  EFC38991.1 243 VTKQLQNITFSLISSVGISNtELSSSLGNAMENLEQER 280
                 56677777777777777777777777777766666554 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.078
                 HHHHHTTT---SGGGGGGSEEEHHHHHHHHHHHHHHHHHHHHS---HHHHHHHHHHHHHHHHHHHHHHHHH CS
       IZUMO  36 ealledlsekelaenkflgvvdeetlekvasslkkelkrltdsdlkgelllkeLlwllqkqkkklkealke 106
                  +ll+d s+ e++en   + ++e++l++  +++ ++ k+l++ + + + l  ++++   ++++k+ke+ ++
  EFC38991.1 435 IDLLSDPSFDEIEENDLFEPLNERKLQDQVKFIENQSKQLKEYEQQLNNLKLNMTNEHAELEQKIKELEQK 505
                 467888899********************************998888887777777776666666665433 PP

  == domain 5  score: -1.6 bits;  conditional E-value: 0.58
                 HHHTHHHHHSGGHHHHHHHHHHHHHTTT---SGGGGGGSEEEHHHHHHHHHHHHHHHHHHHHS---HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
       IZUMO  16 LeedllpselehreklleraealledlsekelaenkflgvvdeetlekvasslkkelkrltdsdlkgelllkeLlwllqkqkkklkealkefqk 109
                 L e l++++l+ + k++e + + l++ +++  +  k     ++++le+  ++l ++ k+l+ ++ k++  l++ ++ l++++kkl+++ ke+ +
  EFC38991.1 451 LFEPLNERKLQDQVKFIENQSKQLKEYEQQLNNL-KLNMTNEHAELEQKIKELEQKKKQLSRESSKEREELSKQVERLKRKEKKLEKMEKEMIE 543
                 5566778888889999999999999988765555.55556688999999**************9999999999999999999999999888754 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.042
                 HSGGHHHHHHHHHHHHHTTT........---SGGGGGGSEEEHHHHHHHHHHHHHHHHHHHHS--- CS
       IZUMO  24 elehreklleraealledls........ekelaenkflgvvdeetlekvasslkkelkrltdsdlk 81 
                 +l+++ek le++e+++ + +         +  ++n+f ++ d+ +  +v+s+lk+ ++++++ + +
  EFC38991.1 526 RLKRKEKKLEKMEKEMIENKskqlniglPRYWKRNSFNRFADRYNTVDVTSQLKDIIQEIMNVSSN 591
                 33344444444444444443333334447778999***********************99987655 PP

>> ISG65-75  Invariant surface glycoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.38   2.3e+03      90     120 ..     177     207 ..     144     224 .. 0.64
   2 ?    6.5  13.5   0.00074       4.4      58     133 ..     459     534 ..     454     547 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.38
    ISG65-75  90 kgtltesdaeklkkaceeAkaknkkarekak 120
                 + +l e++ eklk+++ + ++++ +++++a 
  EFC38991.1 177 YMQLLEEKLEKLKEFIGNYLNEIYSQNNEAV 207
                 4456666678888888888888888888774 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.00074
    ISG65-75  58 etkdklayienakekvdyyvekleslleeakekgtltesdaeklkkaceeAkaknkkarekakkalekaekaskka 133
                 + +d++++ien+ +++++y ++l++l+ ++ ++    e+++++l++  ++  ++ +k+re+  k++e  ++  kk 
  EFC38991.1 459 KLQDQVKFIENQSKQLKEYEQQLNNLKLNMTNEHAELEQKIKELEQKKKQLSRESSKEREELSKQVERLKRKEKKL 534
                 789*****************************999999999************************99999988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (802 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3541  (0.197501); expected 358.6 (0.02)
Passed bias filter:                      734  (0.0409393); expected 358.6 (0.02)
Passed Vit filter:                       177  (0.00987227); expected 17.9 (0.001)
Passed Fwd filter:                        48  (0.00267723); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.36u 0.34s 00:00:01.70 Elapsed: 00:00:00.55
# Mc/sec: 4411.74
//
Query:       EFC38992.1  [L=288]
Description: 3-beta hydroxysteroid dehydrogenase/isomerase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.2e-15   56.8   0.1    3.2e-15   56.2   0.1    1.2  1  Epimerase       NAD dependent epimerase/dehydratase family
    1.1e-14   54.1   0.7    4.7e-14   52.0   0.7    1.8  1  3Beta_HSD       3-beta hydroxysteroid dehydrogenase/isomerase
    2.3e-13   49.9   0.1      3e-13   49.5   0.1    1.1  1  NAD_binding_4   Male sterility protein
    1.5e-08   34.5   0.5    3.4e-08   33.3   0.5    1.5  1  GDP_Man_Dehyd   GDP-mannose 4,6 dehydratase
    1.2e-06   28.6   0.0     0.0056   16.6   0.0    2.9  3  NAD_binding_10  NAD(P)H-binding
    0.00013   21.6   0.0    0.00064   19.3   0.0    2.0  2  NmrA            NmrA-like family


Domain annotation for each model (and alignments):
>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.2   0.1   1.1e-18   3.2e-15       1     231 [.       5     270 ..       5     276 .. 0.78

  Alignments for each domain:
  == domain 1  score: 56.2 bits;  conditional E-value: 1.1e-18
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC.......................EEEE--TT-HHHHHHHHHHHT-SEEEE--S--- CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl.......................elveldltdrsalerlfkeeqpdavihlAavgg 76 
                 ++VtG+tGf+ s+lv +ll kgy+v +  r+ +++ + r++ l                       ++ e+dl+++ ++++++k  ++  v h+A    
  EFC38992.1   5 VCVTGGTGFVASHLVYQLLLKGYHVNTTIRDLKKKDELRDALLqyhkenctdptqllteqvlnerlSIFEADLMKEGSFADVIK--GCRFVHHVASPYK 101
                 79**********************99988886666666555559****************************************..9*******77444 PP

                 HHHHHHSHHHHHHHHTHHHHHHHHHHH.......HHTCT...EEEEEEEGGGGTSCSSSS...BSTCSTTS----SSHHHHHHHHHHHHHHHHHHHHT. CS
   Epimerase  77 vaassedpadfieknlqgtlnlleaar.......kagvk...rllflsSsevYGkdaeqp...keettltgplkpnspYaaaKlageklveayaaqyg. 161
                  ++  + ++++++  ++gtln+l+++        +++v+   r++  sS     + ae+    +e++ ++ ++  ++pY ++K+++ek ++++ ++ + 
  EFC38992.1 102 LDV-KDAQQELVDPAVKGTLNILNECIklrqeqaTHDVNrlqRVIITSSIVAICDTAEKDkiyTEDDWNELSTVDRNPYYYSKVTSEKAAWKLMKEMQt 199
                 444.45557899**************9677766633333666*******666666666323557777777777**************999998888876 PP

                 ......-EEEEEEESEEESTTS-TTSTTSHHHHHHHHHHTTSSSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT CS
   Epimerase 162 ......lnaiilrlfnlyGprngegevsrvipalirkilegkqevtllgdgtalRdflyveDvaeaillvlehvda 231
                       ++  +++++ ++G+   +++v++    +++k+ +g+    l+      + f++v+Dva  ++    h+++
  EFC38992.1 200 khgqdfIELATINPSGVIGKPVLPQQVNQ-THDIVAKVVNGE-MPALI---AMYMTFVDVKDVALSHVKYFYHPKE 270
                 77777777777777777777733333333.344666666677.33333...478999*****99999998888765 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.0   0.7   1.6e-17   4.7e-14       2     184 ..       7     219 ..       6     273 .. 0.80

  Alignments for each domain:
  == domain 1  score: 52.0 bits;  conditional E-value: 1.6e-17
   3Beta_HSD   2 vtGgaGFlGralvkeLvrleelkevrvlDlrespelleelskvnvkk..................viegDvtdkdkleealegvdvvihlaslvdvagk 82 
                 vtGg+GF+ ++lv +L+  +   +  + Dl++++el++ l + + ++                  + e+D++++ +  ++++g   v h+as  ++  k
  EFC38992.1   7 VTGGTGFVASHLVYQLLLKGYHVNTTIRDLKKKDELRDALLQYHKENctdptqllteqvlnerlsIFEADLMKEGSFADVIKGCRFVHHVASPYKLDVK 105
                 9*****************9998888999988888888877776666666677777777888888899******************************** PP

   3Beta_HSD  83 ltedeimkvnvkGTrnvleacvk.......agv...rvlvYtSsaevvgpnslgeeilngdEeleyeslhqdaypesKalaEklvlk.aNgrtlknggr 170
                 + ++e+ +  vkGT n+l+ c+k       ++v   ++++ tSs+ ++ +  ++++i   d+  e+ ++  ++y +sK  +Ek+  k   + + k g++
  EFC38992.1 106 DAQQELVDPAVKGTLNILNECIKlrqeqatHDVnrlQRVIITSSIVAICDTAEKDKIYTEDDWNELSTVDRNPYYYSKVTSEKAAWKlMKEMQTKHGQD 204
                 *********************874444444455111568*******************99999999999*************99866245566788887 PP

   3Beta_HSD 171 lyTca.LRpagiyGe 184
                 ++  a + p+g+ G 
  EFC38992.1 205 FIELAtINPSGVIGK 219
                 766543788888874 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.5   0.1     1e-16     3e-13       1     238 [.       7     245 ..       7     259 .. 0.67

  Alignments for each domain:
  == domain 1  score: 49.5 bits;  conditional E-value: 1e-16
                    EE-TTSHHHHHHHHHHHHHS-.TEEEEEE-....SSSHHHHHHHHHHHT-SS-HHHHHHHHHTTTEEEEE--TTSGGGG--HHHHHHHHHH--EEE CS
  NAD_binding_4   1 lTGaTGFLGkvLlekLLrttpevkiyllvR....aksgesaeeRleeelekkelfsallkelaerikvveGDlseprlGLseedlqelaeevdvii 92 
                    +TG+TGF++++L+ +LL +  +  +   +R    +++ ++a+   ++e  +++ +  + + l er+++ e+Dl+++       ++ ++++ +  + 
     EFC38992.1   7 VTGGTGFVASHLVYQLLLKGYH--VNTTIRdlkkKDELRDALLQYHKENCTDPTQLLTEQVLNERLSIFEADLMKEG------SFADVIKGCRFVH 94 
                    7****************99885..55555521003333455555555555555555554599***********8765......9************ PP

                    E--SS-S.ST..TSSEEHHHHHHHHHHHHHHHTSSS--..........-EEEEEE..GGGTTS-TTT--SSS-H......HHH--EEEETTTCCCH CS
  NAD_binding_4  93 hsaAtvnfde..pykellrvNveGtrevlelakklkkl.........kvllhvST..ayvngeregeveekvyeegekeekldederaklkglpnt 175
                    h+a  +++d     +el+++ v+Gt ++l+ + kl++          + ++  S+  a+++++++            ++  +++d  + ++   n 
     EFC38992.1  95 HVASPYKLDVkdAQQELVDPAVKGTLNILNECIKLRQEqathdvnrlQRVIITSSivAICDTAEK------------DKIYTEDDWNELSTVDRNP 178
                    ****999876336788*****************77777333333333555555664333333333............344578888888888899* PP

                    HHHHHHHHHHHHHHHHHHH---.......EEEEEE-EEE--SSST---TTSHHHHHHHHHHHH-EEES-S CS
  NAD_binding_4 176 YeqsKalaEklvrearrrsglp.......vvivRpsiitgesktGwingsdlgirgllgliakgvlpeil 238
                    Y +sK+ +Ek   + +++ + +       ++ + ps ++g+++   +++ +  ++ +++ +  g +p ++
     EFC38992.1 179 YYYSKVTSEKAAWKLMKEMQTKhgqdfieLATINPSGVIGKPVL--PQQVN-QTHDIVAKVVNGEMPALI 245
                    *********86655554433332223444699999999998876..55555.445555555555555555 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.5   1.1e-11   3.4e-08       2     165 ..       7     191 ..       6     212 .. 0.69

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 1.1e-11
                    EETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTH......HHHHCTTT........TTGCCEEEEE--TT-HHHHHHHHHHHT-SEEEE--S-- CS
  GDP_Man_Dehyd   2 iTGiaGfiGsylaelLlekgyevhgivrrsssfntg......riehlakd.....pkeeleenlklhkgDltDssslerllaevqpdevynLAAqs 86 
                    +TG++Gf+ s+l+ +Ll kgy+v  ++r+ ++ +          ++  +d      ++ l+e+l+++++Dl  + s  ++++ ++   v + A   
     EFC38992.1   7 VTGGTGFVASHLVYQLLLKGYHVNTTIRDLKKKDELrdallqYHKENCTDptqllTEQVLNERLSIFEADLMKEGSFADVIKGCR--FVHHVASPY 100
                    9************************99955443321011111111222221111123345679********************96..69******* PP

                    -HHHHTTSHHHHHHHHTHHHHHHHHHHHHCT.........TTSEEEEEEEGGGG-S-S..SSSB-TT....S-----SHHHHHHHHHHHHHH CS
  GDP_Man_Dehyd  87 hVdvsfekPeytaevnvlGtlrLLeairalgle.......kkvrfyqaStsEvYGkvq..evpqtEt....tpfyPrsPYaaaKlyadwivv 165
                      dv+  + ++ ++  v Gtl++L+ + +l  e       +  r++++S+     +++  +  +tE+      +  r+PY  +K++++  + 
     EFC38992.1 101 KLDVKDAQ-QELVDPAVKGTLNILNECIKLRQEqathdvnRLQRVIITSSIVAICDTAekDKIYTEDdwneLSTVDRNPYYYSKVTSEKAAW 191
                    ****9887.8899***********98887754422333324477777777655555441233467763322345578899888888887665 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   1.9e-06    0.0056       1      53 [.       9      59 ..       9      65 .. 0.86
   2 !    8.8   0.0   0.00046       1.4      38      78 ..      67     126 ..      56     196 .. 0.65
   3 ?   -0.6   0.0      0.34     1e+03       3      28 ..     214     238 ..     214     255 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.9e-06
                    TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHHCTTTCEEEE--TT-CCH CS
  NAD_binding_10  1 GAtGkvGrllvkellargghevtalvRnpeklaeleaeeglevvegdvtdved 53
                    G+tG v+++lv +ll + g++v   +R+ +k +el+ ++ l+  + + td+ +
      EFC38992.1  9 GGTGFVASHLVYQLLLK-GYHVNTTIRDLKKKDELR-DALLQYHKENCTDPTQ 59
                    9****************.5**************998.5777777777777665 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00046
                     TTTCEEEE--TT-CCHHHHHHTT-SEEEES---TCC...HHHH................H CS
  NAD_binding_10  38 eeglevvegdvtdvedlaealkgadaVvsalggggk...deeg................a 78 
                     +e+l+++e+d++++ + a+++kg+  V   +++ +    d+++                +
      EFC38992.1  67 NERLSIFEADLMKEGSFADVIKGCRFVHHVASPYKLdvkDAQQelvdpavkgtlnilneC 126
                     699************************988876655443222244555556644444443 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.34
                     TSHHHHHHHHHHHHC-T-EEEEEETT CS
  NAD_binding_10   3 tGkvGrllvkellargghevtalvRn 28 
                     +G +G+ ++ + ++++ h+++a v n
      EFC38992.1 214 SGVIGKPVLPQQVNQT-HDIVAKVVN 238
                     5889***********5.999997766 PP

>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   2.1e-07   0.00064       1      90 [.       5     116 ..       5     120 .. 0.88
   2 ?   -0.6   0.0      0.27   8.1e+02       3      31 ..     210     238 ..     208     264 .. 0.85

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 2.1e-07
                 EEESSTTSHHHHHHHHHHHHHT-EEEEEES-S.....................-SHHHHHHHHSTTEEEES-TT-HHHHHHHHTT-SEEEE---GGS-H CS
        NmrA   1 IlviGaTGrqGksvvrallkaghkvralvRdt.....................kselakslkeaGvelvkgdlddkeslvealkgvdvvfsvtgfyske 78 
                 + v+G+TG  ++++v  ll +g++v   +Rd+                     ++ l +++ ++   + ++dl  + s + ++kg   v  v + y+  
  EFC38992.1   5 VCVTGGTGFVASHLVYQLLLKGYHVNTTIRDLkkkdelrdallqyhkenctdpTQLLTEQVLNERLSIFEADLMKEGSFADVIKGCRFVHHVASPYKLD 103
                 679*****************************9999999999999999999888888888888889999999999999999999999999999988666 PP

                 HHH.HHHHHHHHH CS
        NmrA  79 ied.gkklvdAak 90 
                 ++d +++lvd a+
  EFC38992.1 104 VKDaQQELVDPAV 116
                 6543788888775 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.27
                 ESSTTSHHHHHHHHHHHHHT-EEEEEES- CS
        NmrA   3 viGaTGrqGksvvrallkaghkvralvRd 31 
                  i+++G +Gk v    +++ h++ a v +
  EFC38992.1 210 TINPSGVIGKPVLPQQVNQTHDIVAKVVN 238
                 68999999999999999999999887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       660  (0.0368119); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.66u 0.38s 00:00:01.04 Elapsed: 00:00:00.56
# Mc/sec: 1561.30
//
Query:       EFC38993.1  [L=132]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.4e-09   38.2   0.0    1.6e-09   38.0   0.0    1.1  1  Roc        Ras of Complex, Roc, domain of DAPkinase
    1.7e-07   31.0   0.0    2.1e-07   30.7   0.0    1.1  1  Ras        Ras family
  ------ inclusion threshold ------
      0.017   14.5   0.0      0.024   14.0   0.0    1.4  1  Gtr1_RagA  Gtr1/RagA G protein conserved region


Domain annotation for each model (and alignments):
>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.0   0.0   2.7e-13   1.6e-09       1     119 [.       3     120 ..       3     121 .. 0.84

  Alignments for each domain:
  == domain 1  score: 38.0 bits;  conditional E-value: 2.7e-13
                 EEEEESSTTSSHHHHHHCHCT-CC...C-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkf...sekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srsse 93 
                 Kv+l G++++GKts+ +  ++d+    ++   + ig+df+ k++ +i +       +k+kl++WD    er+  +   ++r+ + ++l+ +   s+ ++
  EFC38993.1   3 KVLLDGEHKSGKTSFHECAMKDSPvslNPFILPPIGIDFAVKQF-NIGQ------ETKLKLELWDSYSGERVLHIPFTFYRATSTILLLGNpysSNVKH 94 
                 89999***************98752237788999*******997.4433......24689**********************99999986644255566 PP

                 CHHHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  94 nlkeWlkelkkvagkspvilvgnkiD 119
                  +++  +e++++a +  vil+ +k D
  EFC38993.1  95 VFDYKKEEFRTHAINPEVILLTTKSD 120
                 7799999*****************99 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.7   0.0   3.5e-11   2.1e-07       1     119 [.       3     124 ..       3     130 .. 0.81

  Alignments for each domain:
  == domain 1  score: 30.7 bits;  conditional E-value: 3.5e-11
                 EEEEEESTTSSHHHHHHHHHHSS...CSSSCTTTSSEEEEEEEEEET.TEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdk...FkeeyesTigvdfytkeievd.gkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwve 95 
                 K++l G+   GKts+    +kd+    +    + ig+df +k++++  ++++kle+wD    e+  ++  ++yr ++ ill+ +  s+   ++v ++ +
  EFC38993.1   3 KVLLDGEHKSGKTSFHECAMKDSpvsLNPFILPPIGIDFAVKQFNIGqETKLKLELWDSYSGERVLHIPFTFYRATSTILLLGNPYSS-NVKHVFDYKK 100
                 788889*********9999998622256677899************85789****************************998665544.4566666655 PP

                 H.HHHHSTTTSEEEEEEETTTGGGG CS
         Ras  96 e.ikrvaeenvpivLvGnKvDleek 119
                 e ++++a  n +++L+ +K+Dle++
  EFC38993.1 101 EeFRTHAI-NPEVILLTTKSDLENS 124
                 50555555.79***********985 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   3.9e-06     0.024       1      56 [.       3      62 ..       3     118 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.9e-06
   Gtr1_RagA  1 kvLLmGksgsGKtsmrsiiFdn....ylardtlrlgatidveksevrflgnltlnlwDcg 56
                kvLL G+++sGKts ++   +     + +     +g+   v++ ++    +l+l+lwD  
  EFC38993.1  3 KVLLDGEHKSGKTSFHECAMKDspvsLNPFILPPIGIDFAVKQFNIGQETKLKLELWDSY 62
                8****************99986221134555666788888999999999999*****954 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       400  (0.0223102); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 801.29
//
Query:       EFC38994.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-08   34.9   0.3    1.7e-08   34.4   0.3    1.2  1  DUF962    Protein of unknown function (DUF962)


Domain annotation for each model (and alignments):
>> DUF962  Protein of unknown function (DUF962)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.4   0.3   9.7e-13   1.7e-08       8      78 ..       6      80 ..       2      94 .. 0.77

  Alignments for each domain:
  == domain 1  score: 34.4 bits;  conditional E-value: 9.7e-13
      DUF962  8 yafYlaeHsnpinrllHfigvplill...tvlllllraklkllla..lfvvgyifafvGHfvfEkrkPAlfknplq 78
                ++ Y++ Hs +in llH+++vpl ++   ++++l++ +++  ++   +++++ +++ +GH+ +E +kP  f+ p+ 
  EFC38994.1  6 LNVYQSRHSSKINLLLHLFFVPLFMVgsiLTIVLFFIQPFLSIIGfpIMAIAMGMQNIGHK-LETNKPEPFTGPWD 80
                679*******************98762224455566667655555115667899*******.**********9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       670  (0.0373696); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 831.95
//
Query:       EFC38995.1  [L=352]
Description: GCN5-related N-acetyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.5e-05   25.3   0.0    3.7e-05   24.1   0.0    1.7  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
    2.2e-05   24.4   0.0    5.1e-05   23.2   0.0    1.6  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    4.1e-05   23.8   0.0    8.5e-05   22.8   0.0    1.6  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    0.00033   20.6   0.0    0.00078   19.4   0.0    1.6  1  FR47             FR47-like protein
     0.0018   18.4   0.0     0.0035   17.4   0.0    1.4  1  Acetyltransf_CG  GCN5-related N-acetyl-transferase
  ------ inclusion threshold ------
      0.023   14.2   0.0      0.077   12.5   0.0    1.7  2  Acetyltransf_15  Putative acetyl-transferase
      0.073   13.1   0.0       0.34   10.9   0.0    2.3  2  Acetyltransf_13  ESCO1/2 acetyl-transferase
        0.1   13.2   0.0        0.2   12.3   0.0    1.5  1  Acetyltransf_3   Acetyltransferase (GNAT) domain


Domain annotation for each model (and alignments):
>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0   1.6e-08   3.7e-05       5      76 .]     252     340 ..     248     340 .. 0.62

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.6e-08
                     EEEEEET.TEEEEEEEEEEES..TCTEEEEE-GGGTTSSHHHHHHHH.........TTSE.EEEE.EEEE....THHHHHHHHHHTTEEE CS
  Acetyltransf_7   5 vfVaedd.gkivGfialslld..aeitrlaVdpeyrgkGiGraLlea.........aekg.iile.qlel....naekaikfYeklGFee 76 
                     ++V  ++  +++  + ++++   + it++++ +eyrg+Gi++ L++          + +g  +l+    l    +++++++ Y + GF+e
      EFC38995.1 252 FYVTMKGnSNPIAIALATPIPsaCRITHVFTEEEYRGRGIASFLIQSmsmqlferkE-EGgNQLFkWMFLtadsSNPTSNGVYVRSGFKE 340
                     5554444455556555566668789999*****************944666665421.33212222223332323337888******986 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.0   2.3e-08   5.1e-05      27     111 ..     247     343 ..     229     348 .. 0.70

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 2.3e-08
  Acetyltransf_10  27 eegealllvaeeggkivGvi...elrdgs..hisllfVdpeyrgqGigkaLleaveee.aekdgikl.......eltvnasp.yavpfYeklGF 106
                      ++g+++++ ++ + +++ ++    +   s  +i+++f ++eyrg+Gi++ L++ +  + +e+++ +         lt+++s+ +  ++Y + GF
       EFC38995.1 247 QKGNTFYVTMKGNSNPIAIAlatPIP--SacRITHVFTEEEYRGRGIASFLIQSMSMQlFERKEEGGnqlfkwmFLTADSSNpTSNGVYVRSGF 338
                      57777777777777777777422224..256************************9995443332212123346689999999*********** PP

  Acetyltransf_10 107 kavge 111
                      k+ +e
       EFC38995.1 339 KEETE 343
                      98765 PP

>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   3.8e-08   8.5e-05      31     117 .]     248     338 ..     216     338 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 3.8e-08
                     TTCEEEE.EEETTEEEEEEEEEEEETTSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHT...TESEE.EE...EEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  31 eaegllv.aeedgeliGfisllkipdekggvayieslaVspeyrgkGlGsaLlealeeraree...gikki.vl...aveedndaairlYeklGF 117
                       ++++v  + + ++i+ + +++ip      + i  ++  +eyrg+G++s L++ +  +++e+   g++ +  +   + +++n  + ++Y + GF
      EFC38995.1 248 KGNTFYVtMKGNSNPIAIALATPIPS----ACRITHVFTEEEYRGRGIASFLIQSMSMQLFERkeeGGNQLfKWmflTADSSNPTSNGVYVRSGF 338
                     33367775777788************....89999*******************99966666657555665455565777779999999999998 PP

>> FR47  FR47-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   3.5e-07   0.00078      23      81 ..     276     342 ..     263     346 .. 0.81

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 3.5e-07
                 SEEEEEE-GGG-SSSHHHHHHHHHHHHHHHS-S-........EEEEEETT-HHHHHHHHHHT-EEEE CS
        FR47  23 elgalqvlpehrrrGlgsrlvkalakeiaergkt........vllvvvasNtpsirlyeklGfekie 81 
                  +  + +++e r+rG +s l+++++ ++ er ++        ++l +  sN +s  +y + Gf++ +
  EFC38995.1 276 RITHVFTEEEYRGRGIASFLIQSMSMQLFERKEEggnqlfkwMFLTADSSNPTSNGVYVRSGFKEET 342
                 678899**********************9965432333333367888999*************9874 PP

>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   1.6e-06    0.0035      25      49 ..     275     299 ..     257     307 .. 0.91

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.6e-06
  Acetyltransf_CG  25 ldfthTeVpeelrGkGiAkkLvkaa 49 
                        +th++++ee+rG+GiA+ L++++
       EFC38995.1 275 CRITHVFTEEEYRGRGIASFLIQSM 299
                      579******************9976 PP

>> Acetyltransf_15  Putative acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.91     2e+03     178     194 ..     107     122 ..      91     144 .. 0.57
   2 ?   12.5   0.0   3.4e-05     0.077      75     138 ..     277     340 ..     266     345 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.91
  Acetyltransf_15 178 ylamfckvndflnkkki 194
                       l mfc v+ + n  + 
       EFC38995.1 107 VLKMFCSVD-YRNLRIS 122
                      456666543.3333322 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 3.4e-05
  Acetyltransf_15  75 iYtlyvsekyrgkGlakklLeeslkelkknYkvdnelllaLHlnpkDksMnisfalYyslgFrk 138
                      i +++++e+yrg+G+a  l++   ++l  + +   ++l+      +D s + s  +Y+  gF++
       EFC38995.1 277 ITHVFTEEEYRGRGIASFLIQSMSMQLFERKEEGGNQLFKWMFLTADSSNPTSNGVYVRSGFKE 340
                      66899***************99999999988888899999999999***************986 PP

>> Acetyltransf_13  ESCO1/2 acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.5   5.6e+03       6      22 ..     106     122 ..     103     124 .. 0.82
   2 ?   10.9   0.0   0.00015      0.34       4      32 ..     274     302 ..     271     345 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.5
  Acetyltransf_13   6 GisriWvssshRrkgiA 22 
                      G+ ++++s ++R+ +i 
       EFC38995.1 106 GVLKMFCSVDYRNLRIS 122
                      89999999999998886 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00015
  Acetyltransf_13   4 lcGisriWvssshRrkgiAtkLldaaren 32 
                       c i  +++ +++R +giA+ L++++  +
       EFC38995.1 274 ACRITHVFTEEEYRGRGIASFLIQSMSMQ 302
                      68899******************988765 PP

>> Acetyltransf_3  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0     9e-05       0.2      51     138 .]     247     339 ..     211     339 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 9e-05
  Acetyltransf_3  51 eegygwaivlkdtgv.iGsvglrdleeedeeaelgymlaps.fwgkGyateavralleyafeel......glerlvavidkeNeaSirvleklGf 137
                     ++g ++ ++ k+++  i ++  ++++     + +  ++ ++ ++g+G+a+   +++   +fe+         ++++ ++d +N+ S  v+ + Gf
      EFC38995.1 247 QKGNTFYVTMKGNSNpIAIALATPIPSA---CRITHVFTEEeYRGRGIASFLIQSMSMQLFERKeeggnqLFKWMFLTADSSNPTSNGVYVRSGF 338
                     4454555555555433666666666665...99999999777*************9888886666777766779********************* PP

  Acetyltransf_3 138 e 138
                     +
      EFC38995.1 339 K 339
                     7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (352 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       443  (0.0247086); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.41
# Mc/sec: 2558.34
//
Query:       EFC38996.1  [L=212]
Description: hypothetical protein NAEGRDRAFT_81437 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-06   28.0   0.0    2.9e-06   27.3   0.0    1.3  1  MMR_HSR1         50S ribosome-binding GTPase
     0.0009   18.4   0.0      0.002   17.3   0.0    1.5  1  IIGP             Interferon-inducible GTPase (IIGP)
     0.0016   18.5   0.1     0.0048   17.0   0.0    1.8  2  Dynamin_N        Dynamin family
  ------ inclusion threshold ------
      0.014   14.8   0.0      0.034   13.5   0.0    1.6  2  FtsK_SpoIIIE     FtsK/SpoIIIE family
      0.016   15.4   0.0      0.038   14.2   0.0    1.6  1  Roc              Ras of Complex, Roc, domain of DAPkinase
      0.022   13.9   0.0      0.036   13.2   0.0    1.5  1  G-alpha          G-protein alpha subunit
      0.024   14.4   0.0      0.055   13.2   0.0    1.6  1  AAA_24           AAA domain
      0.038   14.3   0.0       0.45   10.8   0.0    2.3  2  AAA_22           AAA domain
      0.063   13.0   0.5       0.07   12.8   0.5    1.3  1  AAA_15           AAA ATPase domain
      0.068   12.4   0.2       0.18   11.1   0.0    1.8  3  Septin           Septin
      0.096   12.3   0.0          1    8.9   0.0    2.2  2  Ras              Ras family
        4.3    7.1   5.1        1.4    8.6   0.5    2.2  2  Antimicrobial19  Pseudin antimicrobial peptide


Domain annotation for each model (and alignments):
>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.3   0.0     2e-09   2.9e-06       1      90 [.      12     125 ..      12     158 .. 0.63

  Alignments for each domain:
  == domain 1  score: 27.3 bits;  conditional E-value: 2e-09
                 EEEEEESTTSSHHHHHHHHHT........STEEESSSTTS.SSSEEEEEEEETTEEEEEEECGGC..............SSHHHHHHHHHHHHHH.... CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltg........ekaivsdkpgt.TrdinegrvklkgkeielvDtpGl..............iegaseekglgkafla.... 72 
                 ++++vG p +GKS++in+l++        e++ v++k+ + T+  +   v+    ++ l D +G               ++g +++ +l +++l     
  EFC38996.1  12 KILVVGDPHSGKSSFINTLLKffnpnimvETCDVGRKAEVgTLLYESVPVS--SANLLLFDSAGKpfenpddlntlkliLQGIKTGTNLVENYLTnkid 108
                 589*****************9775655545666665554424444555555..789********54455555555555433444555555555553332 PP

                 .HHCTSEEEEEEETTTTCS CS
    MMR_HSR1  73 .leeadlillvvdaseekl 90 
                   ++ d++++v++a  e +
  EFC38996.1 109 lDNRIDAVIFVCRAC-E-W 125
                 25579******9855.2.3 PP

>> IIGP  Interferon-inducible GTPase (IIGP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   1.3e-06     0.002      30      55 ..       5      30 ..       2      35 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.3e-06
                HHHT--EEEEEEESTTSSHHHHHHHH CS
        IIGP 30 eiesaklkiavtGdsGnGkssFinaL 55
                ++ + +lki v+Gd  +GkssFin+L
  EFC38996.1  5 TLPNLPLKILVVGDPHSGKSSFINTL 30
                567889*******************8 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   3.2e-06    0.0048       1      20 [.      13      32 ..      13      42 .. 0.92
   2 ?   -1.0   0.0       1.1   1.6e+03     120     128 ..      97     106 ..      52     159 .. 0.62

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3.2e-06
                EEEEEBTTTTHHHHHHHHHT CS
   Dynamin_N  1 iavvGsqSsGKSSvlnaLlg 20
                i+vvG+  sGKSS++n Ll+
  EFC38996.1 13 ILVVGDPHSGKSSFINTLLK 32
                89****************97 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.1
                 HHHHHHH.ST CS
   Dynamin_N 120 elvkeyi.kk 128
                 +lv++y+ +k
  EFC38996.1  97 NLVENYLtNK 106
                 4555554333 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   2.3e-05     0.034      39      60 ..      10      31 ..       3      32 .. 0.86
   2 ?   -2.6   0.0       1.9   2.8e+03     143     161 ..     171     189 ..     144     203 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.3e-05
                  -.SEEEE--TTSSHHHHHHHHH CS
  FtsK_SpoIIIE 39 ashllvaGatgsGKStalntLi 60
                  +  +lv+G + sGKS ++ntL+
    EFC38996.1 10 PLKILVVGDPHSGKSSFINTLL 31
                  5579****************97 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.9
                   HTT---B-TT-........ CS
  FtsK_SpoIIIE 143 ldifgdvflvlDnyddlaa 161
                   ++ +++ f +lDn +dl +
    EFC38996.1 171 KVTNAVPFAFLDNPKDLSK 189
                   3344556666777666655 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   2.5e-05     0.038       1      27 [.      12      37 ..      12      77 .. 0.61

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.5e-05
                EEEEESSTTSSHHHHHHCHCT-CCC-E CS
         Roc  1 KvvlvGdsgvGKtsllkrfvedkfsek 27
                K+++vGd ++GK+s+++ ++ + f+++
  EFC38996.1 12 KILVVGDPHSGKSSFINTLL-KFFNPN 37
                9****************999.445544 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   2.4e-05     0.036      23      61 ..      10      49 ..       4     192 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.4e-05
                EEEEEEEESTTSSHHHHHHHHHHHCS----HHHHHC.CHH CS
     G-alpha 23 evkllllGqseSGKsTilkqlkllykkgfseeelat.wra 61
                ++k+l++G   SGKs++++ l ++++++++ e +    +a
  EFC38996.1 10 PLKILVVGDPHSGKSSFINTLLKFFNPNIMVETCDVgRKA 49
                579**********************999888855332333 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   3.7e-05     0.055       3      34 ..      11      46 ..       9      55 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 3.7e-05
      AAA_24  3 lkiliyGpsgiGKTtlakel....gpkplfidtekG 34
                lkil++G++ +GK++++++l     p++ +  ++ G
  EFC38996.1 11 LKILVVGDPHSGKSSFINTLlkffNPNIMVETCDVG 46
                79******************8888888777666666 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0    0.0003      0.45       8      38 ..      13      47 ..      11      97 .. 0.79
   2 ?    0.9   0.0      0.33     5e+02      19      65 ..     127     177 ..     126     206 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0003
      AAA_22  8 lvvtGesGtGKTtllrrlleqldeeakaee....e 38
                ++v+G +++GK+  +++ll+ ++  +  e+    +
  EFC38996.1 13 ILVVGDPHSGKSSFINTLLKFFNPNIMVETcdvgR 47
                79******************996544444444441 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.33
      AAA_22  19 Ttllrrlleqldeeakaee....erpevvfvtlpsstsskdllrellralg 65 
                 +++l+++++  +++++ +      +p +v+   ++s+s k++  ++ +a+ 
  EFC38996.1 127 SVSLQKFVKFQNAVKETDVkglpFNPMIVLTHFTESMSEKQFVDKVTNAVP 177
                 677788888777776666677877777778888888888888888888775 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.5   4.7e-05      0.07      26      55 ..      13      65 ..       6     206 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 4.7e-05
      AAA_15 26 tvliGkNnsGKSsilealdlFlnnkekkn.......................k 55
                 +++G   sGKSs+++ l +F+n +   +                       +
  EFC38996.1 13 ILVVGDPHSGKSSFINTLLKFFNPNIMVEtcdvgrkaevgtllyesvpvssaN 65
                5899*******************884433555666666666666666655550 PP

>> Septin  Septin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00012      0.18       4      26 ..      10      32 ..       8      54 .. 0.88
   2 ?   -3.6   0.0       3.4   5.1e+03     106     119 ..     106     119 ..      92     123 .. 0.70
   3 ?   -2.5   0.0       1.6   2.4e+03     191     207 ..     165     181 ..     135     194 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00012
                EEEEEEEEBTTSSCCCCCCTTSS CS
      Septin  4 eftlmvvGesglGkttlintlfe 26
                 + ++vvG+   Gk+++intl++
  EFC38996.1 10 PLKILVVGDPHSGKSSFINTLLK 32
                5789****************985 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 3.4
                 SS-----EEEEEEE CS
      Septin 106 kkivDkRvHaclyf 119
                 k   D+R+ a+++ 
  EFC38996.1 106 KIDLDNRIDAVIFV 119
                 44568888888875 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 1.6
                 HHHHHHHHHHC-SEEB- CS
      Septin 191 akelseklkeslPfaiv 207
                  k+   k+++++Pfa +
  EFC38996.1 165 EKQFVDKVTNAVPFAFL 181
                 35566778888888866 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.0   0.00068         1       1      57 [.      12      73 ..      12      76 .. 0.61
   2 ?    0.6   0.0      0.26   3.9e+02     108     137 ..     101     149 ..      76     174 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00068
                EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEE..EEEEEEEET...TEEEEEEEEEETT CS
         Ras  1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvd..fytkeievd...gkevkleiwDTAG 57
                K+++vGd + GK+s+++   k   ++ + +T  v     + ++ ++    ++++l ++D AG
  EFC38996.1 12 KILVVGDPHSGKSSFINTLLKFFNPNIMVETCDVGrkAEVGTLLYEsvpVSSANLLLFDSAG 73
                89*************99887765555566665443112333333333334555666666666 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.26
                 EEEEETTTGGG...................G-SS-HHHHHHHHHHHTSE CS
         Ras 108 vLvGnKvDlee...................kravsteegeelakelglk 137
                   + nK+Dl++                   ++ v+++++ +  + +gl+
  EFC38996.1 101 NYLTNKIDLDNridavifvcracewnsvslQKFVKFQNAVKETDVKGLP 149
                 4467899998888888888888887778876666666666555555555 PP

>> Antimicrobial19  Pseudin antimicrobial peptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.4      0.56   8.4e+02       2       9 ..      27      34 ..      27      35 .. 0.84
   2 ?    8.6   0.5   0.00092       1.4       2      21 ..      82     101 ..      81     102 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.56
  Antimicrobial19  2 lNTLKKVi 9 
                     +NTL K +
       EFC38996.1 27 INTLLKFF 34
                     8***9976 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00092
  Antimicrobial19   2 lNTLKKViQGLHEvIKLvsN 21 
                      lNTLK ++QG      Lv N
       EFC38996.1  82 LNTLKLILQGIKTGTNLVEN 101
                      8*********8766666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       739  (0.0412181); expected 358.6 (0.02)
Passed bias filter:                      665  (0.0370907); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 1237.16
//
Query:       EFC38997.1  [L=135]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.3e-05   23.9   0.0    3.9e-05   23.7   0.0    1.2  1  MMR_HSR1      50S ribosome-binding GTPase
    0.00017   21.3   0.0      0.033   13.8   0.0    2.0  2  SRP54         SRP54-type protein, GTPase domain
    0.00022   21.6   0.0    0.00028   21.2   0.0    1.1  1  RNA_helicase  RNA helicase
     0.0036   17.5   0.0     0.0041   17.3   0.0    1.3  1  Roc           Ras of Complex, Roc, domain of DAPkinase
     0.0049   16.1   0.2      0.053   12.7   0.1    2.0  2  G-alpha       G-protein alpha subunit
     0.0066   15.8   0.1      0.012   15.0   0.1    1.4  1  FtsK_SpoIIIE  FtsK/SpoIIIE family
     0.0099   15.2   0.0      0.012   15.0   0.0    1.3  1  AIG1          AIG1 family
  ------ inclusion threshold ------
      0.021   15.1   0.0      0.023   15.0   0.0    1.2  1  AAA_22        AAA domain
      0.022   14.8   0.0      0.072   13.1   0.0    1.8  2  Dynamin_N     Dynamin family
       0.03   14.7   0.0      0.031   14.6   0.0    1.2  1  AAA_16        AAA ATPase domain
      0.056   12.5   0.0      0.077   12.0   0.0    1.2  1  T2SSE         Type II/IV secretion system protein
      0.091   12.8   0.0       0.11   12.5   0.0    1.1  1  CbiA          CobQ/CobB/MinD/ParA nucleotide binding domain
       0.14   11.5   0.0       0.14   11.5   0.0    1.1  1  TniB          Bacterial TniB protein
       0.16   11.1   0.0        0.2   10.8   0.0    1.2  1  DUF815        Protein of unknown function (DUF815)
       0.16   11.7   0.0       0.27   10.9   0.0    1.4  1  VirE          Virulence-associated protein E


Domain annotation for each model (and alignments):
>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0   3.2e-08   3.9e-05       2      57 ..      12      87 ..      11     134 .. 0.57

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 3.2e-08
                EEEEESTTSSHHHHHHHHHT........STEEESSST.TSSSSEEEEEEE.ETTEEEEEEECGGC..........S CS
    MMR_HSR1  2 vaivGrpNvGKStLinaltg........ekaivsdkp.gtTrdinegrvk.lkgkeielvDtpGl..........i 57
                ++++G   +GKS+ in+l++        + + v++k+   T + ++ ++   +g+e+++ Dt+G           +
  EFC38997.1 12 ILVLGPQHSGKSSTINTLCKyfnrriqvASCDVGRKAdVGTVHYEKVHLGsSNGHEYHIFDTAGKpfekgmdgndV 87
                899****************8664433222334444442334444444444455699********422223222220 PP

>> SRP54  SRP54-type protein, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.0   0.00029      0.35       3      43 ..      11      48 ..       9      50 .. 0.85
   2 !   13.8   0.0   2.7e-05     0.033      51     149 ..      33     133 ..      31     134 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00029
                EEEEEESTTSSHHHHHHHHHHHHHHTTS-EEEEEESTSSTT CS
       SRP54  3 villvGlqGaGKTttlaKLaallkkegkkvllvaaDtfRaa 43
                 il++G+q +GK +t+  L +++++   ++ ++++D+ R a
  EFC38997.1 11 NILVLGPQHSGKSSTINTLCKYFNR---RIQVASCDVGRKA 48
                699*****************99976...5778888888876 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 2.7e-05
                 HHHHTTEEEEESSTTSCHHHHHHHHHHHHHHTTSSEEEEEE--SSTTHHHHHHHHHHHHHHH..SSSEEEEEEETTBHTHHHHHHHHHHHHSSCSEEEE CS
       SRP54  51 laeklgvpvikkkeeadpaavakeavekakeekidvvlvDTaGrlqndkelmeelkkikkvv..kpdevllvldattgqeavkqakaFkeavgitgvil 147
                 + ++++v  ++  ++ad  +v +e+v+   ++++++ + DTaG+  ++    +++++i+k +   p+ v l l+  + +e vk+       + +++ +l
  EFC38997.1  33 FNRRIQVASCDVGRKADVGTVHYEKVHLGSSNGHEYHIFDTAGKPFEKGMDGNDVNQIQKLIhgLPTGVNLSLSEWMNSEIVKENVVGFVFLVVSAEVL 131
                 56789999999999*******************************999999999999999886667778888877777777775544444444666666 PP

                 ES CS
       SRP54 148 tk 149
                 tk
  EFC38997.1 132 TK 133
                 65 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   2.3e-07   0.00028       1      86 [.      12     103 ..      12     115 .. 0.87

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 2.3e-07
  RNA_helicase   1 iwlyGpsgeGKStlakeLakallkkl.....klkkkdsvysrnpeddfwdgYtgqevvvidDfgqvkdee.npsdlaelirlvsstpyplnm 86 
                   i++ Gp++ GKS+++++L+k + +++     +  +k +v +   e+ ++ + +g+e++++d  g+  ++  + +d++++ +l+   p  +n 
    EFC38997.1  12 ILVLGPQHSGKSSTINTLCKYFNRRIqvascDVGRKADVGTVHYEKVHLGSSNGHEYHIFDTAGKPFEKGmDGNDVNQIQKLIHGLPTGVNL 103
                   6899*******************999999999999999999999******************999999887888999999999877766665 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.5e-06    0.0041       2      66 ..      12      76 ..      11     125 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.5e-06
                EEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEE.CG..GSGGCTTBTTTTCEEEEEEEE-SG CS
         Roc  2 vvlvGdsgvGKtsllkrfvedkfsekekstigvdfltke.vt..kikgvendkkvkkvklniWDtaGq 66
                ++++G +++GK+s ++ +++  f++ + +  ++d+ +k  v   + ++v+   + +  +++i+DtaG+
  EFC38997.1 12 ILVLGPQHSGKSSTINTLCK-YFNR-RIQVASCDVGRKAdVGtvHYEKVHLG-SSNGHEYHIFDTAGK 76
                899****************5.4433.34444455544320220034444443.345689********7 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.1   4.4e-05     0.053      21      47 ..       7      33 ..       1      43 [. 0.80
   2 ?    1.7   0.0     0.096   1.1e+02     186     212 ..      50      76 ..      38      80 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.4e-05
                ..EEEEEEEESTTSSHHHHHHHHHHHC CS
     G-alpha 21 krevkllllGqseSGKsTilkqlklly 47
                k+  ++l+lG + SGKs++++ l +++
  EFC38997.1  7 KKSTNILVLGPQHSGKSSTINTLCKYF 33
                4578****************9987665 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.096
                 ----SEEEEEEECT-TEEEEEEEE-SS CS
     G-alpha 186 lktvGisetkfevdsklefrivdvgGq 212
                 + tv  +++++  ++++e++i+d++G+
  EFC38997.1  50 VGTVHYEKVHLGSSNGHEYHIFDTAGK 76 
                 445555555555588**********97 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.1     1e-05     0.012      36      59 ..       7      29 ..       2      31 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1e-05
                  GGS-.SEEEE--TTSSHHHHHHHH CS
  FtsK_SpoIIIE 36 kkmashllvaGatgsGKStalntL 59
                  kk++ ++lv+G + sGKS ++ntL
    EFC38997.1  7 KKST-NILVLGPQHSGKSSTINTL 29
                  5667.******************9 PP

>> AIG1  AIG1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0     1e-05     0.012       2      28 ..      11      35 ..      10     103 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1e-05
                EEEEESSTTSSHHHHHHHHHTS--SS- CS
        AIG1  2 tivlvGktgnGkSaTgNsilgkkaFes 28
                +i+++G   +GkS+T+N++   k+F+ 
  EFC38997.1 11 NILVLGPQHSGKSSTINTLC--KYFNR 35
                8*****************94..23333 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.0   1.9e-05     0.023       5      58 ..       9      68 ..       5     119 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.9e-05
      AAA_22  5 agilvvtGesGtGKTtllrrlleqldeeakaee......erpevvfvtlpsstsskdllr 58
                 + ++v G+ ++GK+ ++++l + ++++++ +       +++++v+++  +++ss     
  EFC38997.1  9 STNILVLGPQHSGKSSTINTLCKYFNRRIQVAScdvgrkADVGTVHYEKVHLGSSNGHEY 68
                57899*********************999999999**99999999999888887766555 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0     6e-05     0.072       1      19 [.      12      30 ..      12      39 .. 0.93
   2 ?   -1.8   0.0       2.3   2.7e+03      16      34 ..     116     134 ..     114     134 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 6e-05
                EEEEEBTTTTHHHHHHHHH CS
   Dynamin_N  1 iavvGsqSsGKSSvlnaLl 19
                i+v+G q sGKSS +n L+
  EFC38997.1 12 ILVLGPQHSGKSSTINTLC 30
                89**************997 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2.3
                 HHHHTS--S---SSS---S CS
   Dynamin_N  16 naLlgedilprgpnptTrr 34 
                 ++++g  +l++++++ T r
  EFC38997.1 116 ENVVGFVFLVVSAEVLTKR 134
                 7899999999999999975 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   2.6e-05     0.031      25      56 ..      10      40 ..       3      97 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 2.6e-05
      AAA_16 25 elvllsGesGvGKsslvrellralekdggifl 56
                 ++l+ G++ +GKss +++l ++++++ + ++
  EFC38997.1 10 TNILVLGPQHSGKSSTINTLCKYFNRR-IQVA 40
                799*******************99999.4443 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   6.4e-05     0.077     128     156 ..       8      36 ..       4      64 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 6.4e-05
       T2SSE 128 erglilvsGgTgsGKttllyallkeinks 156
                 +  +ilv G+  sGK+ ++++l k++n +
  EFC38997.1   8 KSTNILVLGPQHSGKSSTINTLCKYFNRR 36 
                 5789*********************9987 PP

>> CbiA  CobQ/CobB/MinD/ParA nucleotide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   9.6e-05      0.11      10      74 ..      20     116 ..      18     133 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 9.6e-05
                 SSHHHHHHHHHHHHHHTT--EEEEEEEESSCCCCHHTTEB-HHHH...........................CCHCCCHHHHHHCHCHHHH........ CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........................xxxxxxxxxxxxxxxxxxx........ RF
        CbiA  10 vGKTtlaanLaralarrglrVllvDaDpqannlaileglendiep...........................dlkrllellealgkkkall........ 73 
                 +GK+++  +L+++++r   r+++  +D+ ++++    g++ +++                            d+ ++ +l++ l ++++l         
  EFC38997.1  20 SGKSSTINTLCKYFNR---RIQVASCDVGRKADV---GTVHYEKVhlgssngheyhifdtagkpfekgmdgnDVNQIQKLIHGLPTGVNLSlsewmnse 112
                 7***************...999999999988876...66666666788888888899999999999999999888888888888888776665555555 PP

                 .... CS
                 ...x RF
        CbiA  74 ...l 74 
                     
  EFC38997.1 113 ivkE 116
                 5444 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00012      0.14      28      57 ..       2      31 ..       1      92 [. 0.80

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00012
        TniB 28 eypkrkrmpnlllvGdsnnGKtmivekFar 57
                +y ++k+  n+l++G+++ GK++ ++  ++
  EFC38997.1  2 KYNPNKKSTNILVLGPQHSGKSSTINTLCK 31
                67788899**************88775444 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00016       0.2      50      80 ..       6      36 ..       1      53 [. 0.83

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00016
      DUF815 50 glpannvLLwGarGtGKSslvkallneyaee 80
                ++++ n+L+ G + +GKSs++ +l + ++++
  EFC38997.1  6 NKKSTNILVLGPQHSGKSSTINTLCKYFNRR 36
                67899*****************999887765 PP

>> VirE  Virulence-associated protein E
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00023      0.27      45      76 ..       3      33 ..       1      44 [. 0.89

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00023
        VirE 45 lePgiKfDfvlvLvGkqgsgKstfleklgeew 76
                ++P+ K   +lvL G+q sgKs+++++l +++
  EFC38997.1  3 YNPNKKSTNILVL-GPQHSGKSSTINTLCKYF 33
                79999*9999998.**************9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (135 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       443  (0.0247086); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        78  (0.00435049); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.58u 0.34s 00:00:00.92 Elapsed: 00:00:00.54
# Mc/sec: 746.83
//
Query:       EFC38998.1  [L=624]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   12.2   3.8        4.2    7.0   0.1    3.6  4  DUF4874   Domain of unknown function (DUF4874)


Domain annotation for each model (and alignments):
>> DUF4874  Domain of unknown function (DUF4874)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1     0.029   5.2e+02      34      72 ..      79     117 ..      46     148 .. 0.66
   2 ?   -3.3   0.0      0.34   6.1e+03      57      71 ..     300     314 ..     296     316 .. 0.80
   3 ?    7.0   0.1   0.00023       4.2      24      72 ..     381     433 ..     356     443 .. 0.82
   4 ?    3.0   0.0    0.0041        73      43      78 ..     495     538 ..     461     565 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.029
     DUF4874  34 leiyLkdfrdkdlseealdklekiletlrkagkkvilRf 72 
                 + + +k f  +  s ++l++l++i++ + k+ k+  + +
  EFC38998.1  79 RLFEMKPFWWNATSMSQLEQLNNIVDQVSKSMKSEMIKI 117
                 457788888888888888888888888888777665555 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.34
     DUF4874  57 iletlrkagkkvilR 71 
                 +++ ++++++k+i+R
  EFC38998.1 300 QVKQFKAEDIKAIVR 314
                 677899999999999 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.00023
     DUF4874  24 rke....eevtlvlleiyLkdfrdkdlseealdklekiletlrkagkkvilRf 72 
                 +++    +e+tl++le++++d  d++++   l+ ++++l+ + ++ +++ + f
  EFC38998.1 381 QDSkwvlREKTLTYLEFKICDIYDENVEFLDLTSVRAVLQHFASSSMECMVEF 433
                 2225666899*************************************999877 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.0041
     DUF4874  43 dkdlseealdk.lekiletlrk.agkkvilRfaYdte......g 78 
                 +k+l+e+a ++ l+  ++ l++ ++ +v+lRf+Y++        
  EFC38998.1 495 KKKLKEKANQQfLNLNIQSLQEiQKPDVVLRFIYHNGpptwsdF 538
                 456666666664666677776625568*******9875555550 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (624 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       906  (0.0505327); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.34s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 3691.47
//
Query:       EFC38999.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    7.9e-27   91.9  10.4    1.2e-05   24.9   0.2    7.8  7  TPR_1       Tetratricopeptide repeat
    4.1e-26   88.9   1.1    0.00033   20.5   0.1    7.7  7  TPR_2       Tetratricopeptide repeat
    1.5e-17   62.3   3.7      0.015   15.4   0.1    6.8  7  TPR_8       Tetratricopeptide repeat
    5.1e-17   61.9   0.1    0.00038   20.7   0.0    6.3  4  TPR_12      Tetratricopeptide repeat
    7.1e-13   48.0   4.8      0.014   15.0   0.0    6.0  6  TPR_11      TPR repeat
    1.7e-10   40.2   0.2       0.27   11.4   0.0    6.5  6  TPR_7       Tetratricopeptide repeat
    1.1e-09   38.7   0.0    8.5e-05   23.0   0.0    3.6  3  TPR_19      Tetratricopeptide repeat
      1e-08   35.2   0.2        4.3    8.2   0.0    6.1  6  TPR_6       Tetratricopeptide repeat
    1.1e-08   35.1   3.4      0.017   15.3   0.0    4.9  5  ANAPC3      Anaphase-promoting complex, cyclosome, subunit 3
    1.3e-08   35.4   0.0     0.0027   18.3   0.0    4.5  4  TPR_16      Tetratricopeptide repeat
    8.6e-08   32.4   0.0       0.11   13.3   0.0    5.3  5  TPR_14      Tetratricopeptide repeat
    5.4e-06   26.4   0.2        4.5    7.9   0.0    5.1  4  TPR_17      Tetratricopeptide repeat
      5e-05   23.0   0.0         23    5.0   0.0    5.7  6  TPR_10      Tetratricopeptide repeat
    0.00071   19.7   0.0        1.2    9.3   0.0    4.0  5  TPR_9       Tetratricopeptide repeat
     0.0038   17.3   0.2        3.6    7.7   0.0    4.2  4  Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
     0.0044   16.9   1.8        1.5    8.6   0.0    3.7  4  DUF5113     Domain of unknown function (DUF5113)
  ------ inclusion threshold ------
       0.01   15.3   0.0       0.12   11.7   0.0    2.7  3  TPR_MalT    MalT-like TPR region
      0.019   15.1   0.2        8.2    6.5   0.0    2.6  2  DUF2959     Protein of unknown function (DUF2959)
      0.022   13.7   0.3        0.4    9.5   0.1    2.4  3  NARP1       NMDA receptor-regulated protein 1
       0.11   12.6   0.7      1e+02    3.1   0.0    4.7  5  MIT         MIT (microtubule interacting and transport) domai
        0.2   12.0   3.0    1.5e+02    3.0   0.0    4.6  4  PPR         PPR repeat


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.2   8.7e-06    0.0074      12      34 .]      21      43 ..      20      43 .. 0.94
   2 !   14.0   0.0     4e-05     0.034       2      34 .]      45      77 ..      44      77 .. 0.96
   3 !   16.6   0.1     6e-06    0.0052       3      29 ..      80     106 ..      79     107 .. 0.92
   4 !   24.9   0.2   1.5e-08   1.2e-05       3      31 ..     115     143 ..     114     146 .. 0.93
   5 !   10.8   0.0   0.00039      0.34       6      24 ..     226     244 ..     223     250 .. 0.90
   6 !    7.9   0.0    0.0033       2.8       3      31 ..     392     420 ..     391     421 .. 0.86
   7 ?    0.2   0.0      0.91   7.8e+02      14      26 ..     437     449 ..     430     453 .. 0.59

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 8.7e-06
                HHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1 12 fklgkydeAleyyekALelnPnn 34
                + +gk++eA +y++k L + Pn+
  EFC38999.1 21 YAKGKFKEAADYFDKILDISPNH 43
                889******************97 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 4e-05
                HHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1  2 kalynlGnayfklgkydeAleyyekALelnPnn 34
                +aly +G++++   ++ eA++  ek+L+l+P++
  EFC38999.1 45 EALYHKGVTHYVSANFSEAIKVEEKVLQLDPKH 77
                89*****************************86 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 6e-06
                 HHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALe 29 
                 a+  +Gna+ + g++++A e ++k++ 
  EFC38999.1  80 AYVIKGNAFNERGEFKKAMETFQKCIA 106
                 78889********************96 PP

  == domain 4  score: 24.9 bits;  conditional E-value: 1.5e-08
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALeln 31 
                 +++ lGn+yf +++++  le y+kA+ l 
  EFC38999.1 115 VYNALGNCYFLQEDFNSSLETYNKAIALA 143
                 69************************986 PP

  == domain 5  score: 10.8 bits;  conditional E-value: 0.00039
                 HHHHHHHHTT-HHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyy 24 
                 n+G++++ l+++ eAl+++
  EFC38999.1 226 NKGLTLLCLNRFSEALDCF 244
                 9*****************9 PP

  == domain 6  score: 7.9 bits;  conditional E-value: 0.0033
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALeln 31 
                 +ly +G  +++   y++A++ +e  L+ n
  EFC38999.1 392 VLYFKGEGLRHIRHYQKAIDNFECGLQMN 420
                 67778888888899************998 PP

  == domain 7  score: 0.2 bits;  conditional E-value: 0.91
                 TT-HHHHHHHHHH CS
       TPR_1  14 lgkydeAleyyek 26 
                  ++y+ A + ++k
  EFC38999.1 437 VKDYKAARQIFKK 449
                 3555555555555 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.1   3.4e-06    0.0029      11      34 .]      20      43 ..      18      43 .. 0.95
   2 !   15.3   0.0   1.9e-05     0.016       2      34 .]      45      77 ..      44      77 .. 0.97
   3 ?    6.4   0.0     0.013        11       7      30 ..      84     107 ..      79     110 .. 0.81
   4 !   20.5   0.1   3.9e-07   0.00033       3      33 ..     115     145 ..     114     146 .. 0.93
   5 !    8.3   0.0    0.0033       2.8       6      25 ..     226     245 ..     223     251 .. 0.88
   6 !    6.9   0.1    0.0093       7.9       2      25 ..     391     414 ..     390     420 .. 0.92
   7 ?    4.3   0.0     0.062        53       7      29 ..     430     452 ..     425     455 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 3.4e-06
       TPR_2 11 yyklgdyeeAleafekAleldPnn 34
                +y++g+++eA+++f+k l + Pn+
  EFC38999.1 20 LYAKGKFKEAADYFDKILDISPNH 43
                89********************97 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 1.9e-05
       TPR_2  2 ealynlGlayyklgdyeeAleafekAleldPnn 34
                ealy  G  +y + ++ eA++  ek+l+ldP++
  EFC38999.1 45 EALYHKGVTHYVSANFSEAIKVEEKVLQLDPKH 77
                89*****************************86 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.013
       TPR_2   7 lGlayyklgdyeeAleafekAlel 30 
                  G+a  ++g++++A e f+k+++ 
  EFC38999.1  84 KGNAFNERGEFKKAMETFQKCIAM 107
                 56666689*************975 PP

  == domain 4  score: 20.5 bits;  conditional E-value: 3.9e-07
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPn 33 
                 ++++lG++y+ + d++  le ++kA++l+ +
  EFC38999.1 115 VYNALGNCYFLQEDFNSSLETYNKAIALAID 145
                 699************************9865 PP

  == domain 5  score: 8.3 bits;  conditional E-value: 0.0033
       TPR_2   6 nlGlayyklgdyeeAleafe 25 
                 n Gl ++ l+++ eAl++f 
  EFC38999.1 226 NKGLTLLCLNRFSEALDCFL 245
                 789****************7 PP

  == domain 6  score: 6.9 bits;  conditional E-value: 0.0093
       TPR_2   2 ealynlGlayyklgdyeeAleafe 25 
                 e+ly  G+ +++  +y++A++ fe
  EFC38999.1 391 EVLYFKGEGLRHIRHYQKAIDNFE 414
                 789******************997 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.062
       TPR_2   7 lGlayyklgdyeeAleafekAle 29 
                  G+++++ +dy+ A++ f+k + 
  EFC38999.1 430 VGRVAIAVKDYKAARQIFKKIIN 452
                 58888899999999999999876 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.0   0.00042      0.36      11      34 .]      20      43 ..      10      43 .. 0.88
   2 !    8.3   0.0    0.0035         3       2      34 .]      45      77 ..      44      77 .. 0.94
   3 !   13.9   0.0   5.7e-05     0.048       3      30 ..      80     107 ..      80     110 .. 0.93
   4 !   15.4   0.1   1.8e-05     0.015       3      30 ..     115     142 ..     114     145 .. 0.95
   5 ?    0.5   0.0       1.1   9.6e+02       5      27 ..     225     247 ..     223     251 .. 0.85
   6 ?   -2.5   0.0       9.8   8.4e+03      13      25 ..     402     414 ..     391     419 .. 0.65
   7 ?    6.7   0.0     0.011       9.6       7      30 ..     430     453 ..     424     455 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00042
                HHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8 11 ylklgdyeeAkeyyekaleldpdn 34
                +  +g+++eA  y+ k l+++p++
  EFC38999.1 20 LYAKGKFKEAADYFDKILDISPNH 43
                5679******************97 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0035
                CHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8  2 eayynlgsiylklgdyeeAkeyyekaleldpdn 34
                ea+y++g ++    ++ eA+++ ek+l+ldp++
  EFC38999.1 45 EALYHKGVTHYVSANFSEAIKVEEKVLQLDPKH 77
                899999999999*******************97 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 5.7e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekalel 30 
                 ay+ +g++  + g++++A+e+++k++ +
  EFC38999.1  80 AYVIKGNAFNERGEFKKAMETFQKCIAM 107
                 7999*********************976 PP

  == domain 4  score: 15.4 bits;  conditional E-value: 1.8e-05
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekalel 30 
                 +y+ lg++y+ ++d++++ e+y+ka+ l
  EFC38999.1 115 VYNALGNCYFLQEDFNSSLETYNKAIAL 142
                 69************************87 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 1.1
                 HHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyeka 27 
                 +n+g+++l l+++ eA  ++   
  EFC38999.1 225 LNKGLTLLCLNRFSEALDCFLLI 247
                 689999999********999765 PP

  == domain 6  score: -2.5 bits;  conditional E-value: 9.8
                 HTT-HHHHHHHHH CS
       TPR_8  13 klgdyeeAkeyye 25 
                     y++A+  +e
  EFC38999.1 402 HIRHYQKAIDNFE 414
                 5566777777665 PP

  == domain 7  score: 6.7 bits;  conditional E-value: 0.011
                 HHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   7 lgsiylklgdyeeAkeyyekalel 30 
                  g++ +  +dy++A + ++k + +
  EFC38999.1 430 VGRVAIAVKDYKAARQIFKKIINI 453
                 68888999************9987 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   2.1e-05     0.018      13      76 ..      20      75 ..      10      76 .. 0.93
   2 !   20.7   0.0   4.5e-07   0.00038       6      75 ..      81     143 ..      77     145 .. 0.88
   3 ?    4.8   0.0      0.04        34       4      29 ..     223     247 ..     217     258 .. 0.63
   4 !   11.1   0.0   0.00044      0.37      13      74 ..     400     453 ..     390     455 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 2.1e-05
      TPR_12 13 lrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaiae 76
                l++ g++ eA ++++k l+i      p+h   +++l+  g +++ + ++ eA++  e++l++++
  EFC38999.1 20 LYAKGKFKEAADYFDKILDIS-----PNH---IEALYHKGVTHYVSANFSEAIKVEEKVLQLDP 75
                6899*****************.....*99...99********99888*************9976 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 4.5e-07
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealaia 75 
                 ++  +++ +++g++ +A e ++k++++ +r+++        ++++Lg +y++++++   le +++a+a+a
  EFC38999.1  81 YVIKGNAFNERGEFKKAMETFQKCIAMTNRSFD-------VVYNALGNCYFLQEDFNSSLETYNKAIALA 143
                 5557999999******************88864.......499************************997 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.04
      TPR_12   4 talnnlaavlrrlgrydeAlelleka 29 
                 t+l n +++l+ l r+ eAl+++   
  EFC38999.1 223 TIL-NKGLTLLCLNRFSEALDCFLLI 247
                 334.6666777777777777666555 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00044
      TPR_12  13 lrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                 lr+   y++A++++e  l++        + l+++++++ gr+  a ++y++A++++++ ++i
  EFC38999.1 400 LRHIRHYQKAIDNFECGLQMN-------S-LEIRSMIGVGRVAIAVKDYKAARQIFKKIINI 453
                 555555555555555555555.......3.689************************98876 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.2   3.2e-05     0.027       4      39 ..      20      55 ..      19      56 .. 0.97
   2 ?    2.7   0.0      0.12     1e+02      10      31 ..      60      81 ..      59      82 .. 0.86
   3 !   15.0   0.0   1.7e-05     0.014       1      38 [.      85     123 ..      85     124 .. 0.89
   4 !   13.9   0.0   3.8e-05     0.033       1      28 [.     120     147 ..     120     150 .. 0.90
   5 ?   -0.5   0.0       1.2     1e+03      14      22 ..     403     411 ..     403     411 .. 0.85
   6 ?   -1.5   0.1       2.5   2.1e+03      13      20 ..     436     443 ..     431     446 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 3.2e-05
      TPR_11  4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGlayy 39
                +y++Gk++eA   + k l+++P+  ea+y+ G+++y
  EFC38999.1 20 LYAKGKFKEAADYFDKILDISPNHIEALYHKGVTHY 55
                79*******************************998 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.12
      TPR_11 10 yeeAieaYkkAlkldPdnaeay 31
                + eAi++ +k l+ldP+  +ay
  EFC38999.1 60 FSEAIKVEEKVLQLDPKHRWAY 81
                67999999********977776 PP

  == domain 3  score: 15.0 bits;  conditional E-value: 1.7e-05
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdnaea.yynLGlay 38 
                 G+a+ e+G++++A+e ++k ++ ++ + ++ y++LG+ y
  EFC38999.1  85 GNAFNERGEFKKAMETFQKCIAMTNRSFDVvYNALGNCY 123
                 9***********************999996377788877 PP

  == domain 4  score: 13.9 bits;  conditional E-value: 3.8e-05
      TPR_11   1 GdayyeqGkyeeAieaYkkAlkldPdna 28 
                 G+ y+ q +++ ++e Y+kA++l  dn 
  EFC38999.1 120 GNCYFLQEDFNSSLETYNKAIALAIDNF 147
                 899*******************976665 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 1.2
      TPR_11  14 ieaYkkAlk 22 
                 i +Y+kA++
  EFC38999.1 403 IRHYQKAID 411
                 789****95 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 2.5
      TPR_11  13 AieaYkkA 20 
                 A+++Yk+A
  EFC38999.1 436 AVKDYKAA 443
                 99****99 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.053        45      12      31 ..      23      40 ..      18      45 .. 0.75
   2 ?   -0.2   0.0       1.6   1.4e+03       2      29 ..      47      74 ..      46      78 .. 0.70
   3 !   11.4   0.0   0.00031      0.27       5      34 ..      84     113 ..      80     114 .. 0.86
   4 !    9.7   0.0    0.0011      0.94       2      30 ..     116     144 ..     115     150 .. 0.87
   5 ?    4.0   0.0     0.069        59       1      24 [.     223     246 ..     223     256 .. 0.84
   6 ?    0.5   0.0      0.95   8.1e+02       9      23 ..     400     414 ..     392     417 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.053
       TPR_7 12 lGdyeeAielyeqsLaltkd 31
                 G+++eA++++ +   l+ +
  EFC38999.1 23 KGKFKEAADYFDK--ILDIS 40
                49*********99..55544 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.6
       TPR_7  2 LlnLarlysrlGdyeeAielyeqsLalt 29
                L+  ++++    +++eAi++ e++L+l+
  EFC38999.1 47 LYHKGVTHYVSANFSEAIKVEEKVLQLD 74
                5556666555689*****9999866554 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 0.00031
       TPR_7   5 LarlysrlGdyeeAielyeqsLaltkdped 34 
                  ++++ ++G++++A e +++++a+t++ +d
  EFC38999.1  84 KGNAFNERGEFKKAMETFQKCIAMTNRSFD 113
                 589999******************987665 PP

  == domain 4  score: 9.7 bits;  conditional E-value: 0.0011
       TPR_7   2 LlnLarlysrlGdyeeAielyeqsLaltk 30 
                 +++L+++y+ + d+   +e y +++al+ 
  EFC38999.1 116 YNALGNCYFLQEDFNSSLETYNKAIALAI 144
                 89*********************777764 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.069
       TPR_7   1 aLlnLarlysrlGdyeeAielyeq 24 
                 ++ln + +   l++++eA++++  
  EFC38999.1 223 TILNKGLTLLCLNRFSEALDCFLL 246
                 578999999************976 PP

  == domain 6  score: 0.5 bits;  conditional E-value: 0.95
       TPR_7   9 ysrlGdyeeAielye 23 
                  +  ++y++Ai+ +e
  EFC38999.1 400 LRHIRHYQKAIDNFE 414
                 567789****98776 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   9.9e-08   8.5e-05       1      62 [.      20      80 ..      20      85 .. 0.93
   2 ?    6.4   0.0     0.015        13       3      52 ..      90     140 ..      88     150 .. 0.83
   3 ?    4.8   0.0     0.047        40       7      53 ..     406     452 ..     404     457 .. 0.72

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 9.9e-08
      TPR_19  1 llaegdyaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddarya 62
                l+a g++ eA++++ ++l+ +p++ ea++     ++ + ++ eA+++ +++++ dp+  r+a
  EFC38999.1 20 LYAKGKFKEAADYFDKILDISPNHIEALYHKGVTHYVSANFSEAIKVEEKVLQLDPK-HRWA 80
                6899**************************************************999.6665 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.015
      TPR_19   3 aegdyaeAlalleqalqedpknaearl.lLAeallalgqldeAealLdalp 52 
                 ++g +  A++ +++ ++  + + ++ + +L ++++ + +++   ++ +++ 
  EFC38999.1  90 ERGEFKKAMETFQKCIAMTNRSFDVVYnALGNCYFLQEDFNSSLETYNKAI 140
                 6899**********9888666666666599**********99999988765 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.047
      TPR_19   7 yaeAlalleqalqedpknaearllLAeallalgqldeAealLdalpe 53 
                 y+ A++ +e  lq +    +  ++  ++ +a +++++A+++ +++ +
  EFC38999.1 406 YQKAIDNFECGLQMNSLEIRSMIGVGRVAIAVKDYKAARQIFKKIIN 452
                 66666666666666555555556778899999999999999998865 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0     0.005       4.3       3      33 .]      12      43 ..       9      43 .. 0.79
   2 ?    3.2   0.0      0.19   1.6e+02       1      32 [.      45      76 ..      45      77 .. 0.88
   3 !    7.4   0.0    0.0092       7.8       2      27 ..      80     105 ..      79     106 .. 0.84
   4 ?    4.1   0.0     0.098        83       6      27 ..     119     140 ..     118     142 .. 0.91
   5 ?   -1.9   0.0       8.4   7.2e+03      21      30 ..     404     413 ..     392     414 .. 0.59
   6 ?    4.1   0.0       0.1        86       7      28 ..     431     452 ..     425     453 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.005
                HHHHHHHHHH.HHHHHHHHHHHHHHHHH-TT- CS
       TPR_6  3 lyklalsyrk.lgdtdkAlealerlikeYPdS 33
                l+ ++ s +   g+  +A ++++++++  P++
  EFC38999.1 12 LFERGFSNLYaKGKFKEAADYFDKILDISPNH 43
                5666666665358***************9995 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.19
                HHHHHHHHHHHH.HHHHHHHHHHHHHHHHH-TT CS
       TPR_6  1 dAlyklalsyrk.lgdtdkAlealerlikeYPd 32
                +Aly+ +  ++  + + ++A++  e++++  P+
  EFC38999.1 45 EALYHKGVTHYVsA-NFSEAIKVEEKVLQLDPK 76
                7**********868.******998888888886 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0092
                 HHHHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealerli 27 
                 A+   + ++ + g+  kA+e+++++i
  EFC38999.1  80 AYVIKGNAFNERGEFKKAMETFQKCI 105
                 5666688888988***********98 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.098
                 HHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAlealerli 27 
                 l+ +y+ + d   +le++++ i
  EFC38999.1 119 LGNCYFLQEDFNSSLETYNKAI 140
                 799****98**********988 PP

  == domain 5  score: -1.9 bits;  conditional E-value: 8.4
                 HHHHHHHHH- CS
       TPR_6  21 ealerlikeY 30 
                 + +++ i+++
  EFC38999.1 404 RHYQKAIDNF 413
                 3455555554 PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.1
                 HHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   7 alsyrklgdtdkAlealerlik 28 
                 ++  ++ +d+ +A+++++++i+
  EFC38999.1 431 GRVAIAVKDYKAARQIFKKIIN 452
                 56666646***********997 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0     2e-05     0.017      33      78 ..      20      66 ..      19      70 .. 0.94
   2 !   12.9   0.0   0.00012       0.1       4      49 ..      59     104 ..      56     118 .. 0.88
   3 ?    6.2   0.1     0.014        12      28      49 ..     118     139 ..     105     150 .. 0.80
   4 ?   -1.8   0.1       4.5   3.8e+03      64      79 ..     229     244 ..     218     245 .. 0.75
   5 ?    3.5   0.0     0.095        81      16      81 ..     383     449 ..     364     450 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 2e-05
                HHHTT-HHHHHHHHHCT.SHHHC-HHHHHHHHHHHHHTT-HHHHHHH CS
      ANAPC3 33 lylngqykrAyellrka.klnskslgcrylfAqcllkLkkyeeAiaa 78
                ly  g++k+A ++++k  ++ +++++++y ++ + +   ++ eAi++
  EFC38999.1 20 LYAKGKFKEAADYFDKIlDISPNHIEALYHKGVTHYVSANFSEAIKV 66
                7999*****************************************97 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 0.00012
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclylngqykrAyellrka 49 
                 n+ +Ai + e++l+ ++++  +   ++ ++ ++g++k+A+e ++k+
  EFC38999.1  59 NFSEAIKVEEKVLQLDPKHRWAYVIKGNAFNERGEFKKAMETFQKC 104
                 7899*********999999999999*******************98 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.014
                 HHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  28 llAlclylngqykrAyellrka 49 
                 +l+ c++l++++++ +e ++ka
  EFC38999.1 118 ALGNCYFLQEDFNSSLETYNKA 139
                 489***********99999988 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 4.5
                 HHHHHTT-HHHHHHHH CS
      ANAPC3  64 qcllkLkkyeeAiaaL 79 
                  +ll L+++ eA++++
  EFC38999.1 229 LTLLCLNRFSEALDCF 244
                 6778889999999876 PP

  == domain 5  score: 3.5 bits;  conditional E-value: 0.095
                 H.HHH--HHHHHHHHHHHHHTT-HHHHHHHHHCTSHHHC-HHHHHHHH..HHHHHTT-HHHHHHHH-S CS
      ANAPC3  16 laaetespedayllAlclylngqykrAyellrkaklnskslgcrylfA..qcllkLkkyeeAiaaLek 81 
                  + ++   e +y++++ l +   y++A++ ++   l+ +sl++r  ++  +++++ k y+ A+++++k
  EFC38999.1 383 IEDSRMKREVLYFKGEGLRHIRHYQKAIDNFECG-LQMNSLEIRSMIGvgRVAIAVKDYKAARQIFKK 449
                 4566677777888888888888899999988776.666666555555555999999999999999887 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.0   3.1e-06    0.0027       7      66 ..      20      76 ..      15      78 .. 0.95
   2 !   10.5   0.0   0.00087      0.74       7      58 ..      54     102 ..      50     109 .. 0.91
   3 ?    3.3   0.0      0.16   1.3e+02      37      66 ..     116     145 ..     115     147 .. 0.88
   4 ?    5.0   0.0     0.046        39      12      60 ..     405     450 ..     400     457 .. 0.79

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 3.1e-06
      TPR_16  7 alragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraalraapd 66
                +++ g++ +Aa +++  l+     P + eAl+++g+ +++  ++ eA+ + ++ l+ +p+
  EFC38999.1 20 LYAKGKFKEAADYFDKILDIS---PNHIEALYHKGVTHYVSANFSEAIKVEEKVLQLDPK 76
                7999*****************...*****************************9999996 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00087
      TPR_16   7 alragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyr 58 
                 ++ + ++ +A+++ e +l +d   P ++ A+  +g+a+ ++g++++A + ++
  EFC38999.1  54 HYVSANFSEAIKVEEKVLQLD---PKHRWAYVIKGNAFNERGEFKKAMETFQ 102
                 677889***************...***********************98887 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.16
      TPR_16  37 llllgdaalrqgrlaeAaalyraalraapd 66 
                 +++lg++++ q ++   ++ y++a++ a d
  EFC38999.1 116 YNALGNCYFLQEDFNSSLETYNKAIALAID 145
                 789***************999999988765 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.046
      TPR_16  12 dyddAaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAaalyraa 60 
                 +y++A+  +e  l ++   ++  +++ + g++a + +++++A++ +++ 
  EFC38999.1 405 HYQKAIDNFECGLQMN---SLEIRSMIGVGRVAIAVKDYKAARQIFKKI 450
                 5666666666666666...6666788899**************999875 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   0.00013      0.11      11      42 ..      20      51 ..      10      53 .. 0.90
   2 ?    3.2   0.0      0.23     2e+02      15      38 ..      58      81 ..      51      85 .. 0.88
   3 !    8.7   0.0     0.004       3.4       2      38 ..      79     116 ..      78     122 .. 0.77
   4 ?    1.2   0.0         1   8.8e+02       5      31 ..     117     143 ..     112     156 .. 0.87
   5 ?   -0.4   0.0       3.5     3e+03       8      28 ..     431     451 ..     429     456 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 0.00013
      TPR_14 11 llalGdpdeAiallrralalaPddaeawllla 42
                l+a G+++eA+++++++l+  P++ ea+++ +
  EFC38999.1 20 LYAKGKFKEAADYFDKILDISPNHIEALYHKG 51
                6789***********************99876 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.23
      TPR_14 15 GdpdeAiallrralalaPddaeaw 38
                 ++ eAi++ +++l+l+P++++a+
  EFC38999.1 58 ANFSEAIKVEEKVLQLDPKHRWAY 81
                68999***99**********9997 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.004
      TPR_14   2 eallalaeallalGdpdeAiallrrala.laPddaeaw 38 
                 +a+   + a+ ++G++++A++ +++++a ++ ++++++
  EFC38999.1  79 WAYVIKGNAFNERGEFKKAMETFQKCIAmTNRSFDVVY 116
                 677778999*****************994444455555 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 1
      TPR_14   5 lalaeallalGdpdeAiallrralala 31 
                  al+  ++ ++d+  +++ +++a+ala
  EFC38999.1 117 NALGNCYFLQEDFNSSLETYNKAIALA 143
                 588999999**************9976 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 3.5
      TPR_14   8 aeallalGdpdeAiallrral 28 
                 +++  a  d+++A++++++++
  EFC38999.1 431 GRVAIAVKDYKAARQIFKKII 451
                 567778889999999999875 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0    0.0052       4.5       2      33 ..      33      64 ..      32      65 .. 0.86
   2 ?    5.1   0.0      0.04        34       3      32 ..      68      97 ..      68      99 .. 0.93
   3 ?    6.8   0.0     0.012        10       2      29 ..     101     129 ..     100     134 .. 0.83
   4 ?   -1.9   0.0       6.9   5.9e+03       2      12 ..     136     146 ..     135     171 .. 0.55

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0052
      TPR_17  2 ylkaleldPnnadaynnLAelllknGdlmtAr 33
                + k l++ Pn+ +a++ ++++++   ++ +A+
  EFC38999.1 33 FDKILDISPNHIEALYHKGVTHYVSANFSEAI 64
                8899*****************99777776665 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.04
      TPR_17  3 lkaleldPnnadaynnLAelllknGdlmtA 32
                +k+l+ldP++ +ay  +++++ ++G++++A
  EFC38999.1 68 EKVLQLDPKHRWAYVIKGNAFNERGEFKKA 97
                799***********************9998 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.012
      TPR_17   2 ylkalel.dPnnadaynnLAelllknGdl 29 
                 ++k+++  + +  ++yn L++++  + d+
  EFC38999.1 101 FQKCIAMtNRSFDVVYNALGNCYFLQEDF 129
                 8999999667789**********887775 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 6.9
      TPR_17   2 ylkaleldPnn 12 
                 y ka++l  +n
  EFC38999.1 136 YNKAIALAIDN 146
                 55555443333 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0     0.074        63      12      31 ..      20      39 ..      18      40 .. 0.90
   2 ?   -1.0   0.0       2.1   1.8e+03       9      30 ..      51      72 ..      45      74 .. 0.78
   3 ?    5.0   0.0     0.027        23       9      34 ..      85     110 ..      84     113 .. 0.89
   4 ?    0.5   0.1       0.7     6e+02       5      31 ..     116     142 ..     114     144 .. 0.87
   5 ?    0.5   0.0      0.74   6.3e+02       7      25 ..     226     244 ..     222     256 .. 0.82
   6 ?    4.0   0.0     0.056        48       8      31 ..     430     453 ..     424     459 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.074
      TPR_10 12 lrqrgrydeAealleealai 31
                l++ g+++eA +++++ l+i
  EFC38999.1 20 LYAKGKFKEAADYFDKILDI 39
                7899***********99987 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.1
      TPR_10  9 analrqrgrydeAealleeala 30
                +++++   ++ eA +  e++l+
  EFC38999.1 51 GVTHYVSANFSEAIKVEEKVLQ 72
                6677777789999999999987 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.027
      TPR_10   9 analrqrgrydeAealleealairrr 34 
                 +na  +rg++++A++ +++++a+  r
  EFC38999.1  85 GNAFNERGEFKKAMETFQKCIAMTNR 110
                 788899****************9877 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.7
      TPR_10   5 lnNLanalrqrgrydeAealleealai 31 
                 +n L+n ++ + +++ +++ + +a+a+
  EFC38999.1 116 YNALGNCYFLQEDFNSSLETYNKAIAL 142
                 89***********99999988888875 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.74
      TPR_10   7 NLanalrqrgrydeAeall 25 
                 N + +l  ++r+ eA++ +
  EFC38999.1 226 NKGLTLLCLNRFSEALDCF 244
                 77999999*******9866 PP

  == domain 6  score: 4.0 bits;  conditional E-value: 0.056
      TPR_10   8 LanalrqrgrydeAealleealai 31 
                  +++  ++++y++A++++++ ++i
  EFC38999.1 430 VGRVAIAVKDYKAARQIFKKIINI 453
                 566667788888888888888876 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0      0.15   1.3e+02      31      63 ..      11      44 ..       4      49 .. 0.76
   2 !    8.4   0.0    0.0027       2.3       9      68 ..      24      83 ..      17      84 .. 0.87
   3 !    9.3   0.0    0.0014       1.2       9      59 ..      58     108 ..      52     114 .. 0.91
   4 ?    1.1   0.0      0.54   4.6e+02      25      52 ..     217     244 ..     207     251 .. 0.81
   5 ?   -2.5   0.0       7.2   6.1e+03      19      48 ..     414     443 ..     402     450 .. 0.47

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.15
       TPR_9 31 errdRGll.laqlGclsaAladLeaylalapdap 63
                ++++RG+  l+  G +++A++ ++  l+++p+  
  EFC38999.1 11 LLFERGFSnLYAKGKFKEAADYFDKILDISPNHI 44
                6677776425778999999999999999999654 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0027
       TPR_9  9 edweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaeai 68
                 ++ +a  + + +l + P+++e ++  G+ ++ + ++s+A++  e  l+l+p+ + a+ i
  EFC38999.1 24 GKFKEAADYFDKILDISPNHIEALYHKGVTHYVSANFSEAIKVEEKVLQLDPKHRWAYVI 83
                57889999********************************99888888888877766665 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.0014
       TPR_9   9 edweralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylala 59 
                  ++++a++v e +l+l+P++   +   G +  ++G +++A++ ++ ++a++
  EFC38999.1  58 ANFSEAIKVEEKVLQLDPKHRWAYVIKGNAFNERGEFKKAMETFQKCIAMT 108
                 57899******************************************9986 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.54
       TPR_9  25 aPddpeerrdRGlllaqlGclsaAladL 52 
                  + ++  ++  Gl l  l+++s+Al+++
  EFC38999.1 217 YSGACLTILNKGLTLLCLNRFSEALDCF 244
                 566677788999************9987 PP

  == domain 5  score: -2.5 bits;  conditional E-value: 7.2
       TPR_9  19 erllllaPddpeerrdRGlllaqlGclsaA 48 
                 e  l++++ +++     G++   + +++aA
  EFC38999.1 414 ECGLQMNSLEIRSMIGVGRVAIAVKDYKAA 443
                 333444444444444444444444444444 PP

>> Fis1_TPR_C  Fis1 C-terminal tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0       0.1        90      15      33 ..      24      42 ..      20      46 .. 0.88
   2 !    7.7   0.0    0.0042       3.6       2      35 ..      45      78 ..      44      81 .. 0.93
   3 ?   -0.5   0.0       1.5   1.3e+03       1      21 [.     390     410 ..     390     419 .. 0.88
   4 ?   -0.2   0.0       1.3   1.1e+03      15      30 ..     438     453 ..     435     455 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.1
                T-HHHHHHHHHHHHHHTTS CS
  Fis1_TPR_C 15 geYseArryvdalLeiEPe 33
                g+++eA  y d +L i P+
  EFC38999.1 24 GKFKEAADYFDKILDISPN 42
                789**************98 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0042
                HHHHHHHHHHHHHT-HHHHHHHHHHHHHHTTS-H CS
  Fis1_TPR_C  2 eclYylAlGhyklgeYseArryvdalLeiEPenr 35
                e lY+  + hy   ++seA +  + +L+++P+ r
  EFC38999.1 45 EALYHKGVTHYVSANFSEAIKVEEKVLQLDPKHR 78
                789****************************865 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 1.5
                 HHHHHHHHHHHHHHT-HHHHH CS
  Fis1_TPR_C   1 reclYylAlGhyklgeYseAr 21 
                 re lY+   G   ++ Y++A 
  EFC38999.1 390 REVLYFKGEGLRHIRHYQKAI 410
                 899*******999****9995 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 1.3
                 T-HHHHHHHHHHHHHH CS
  Fis1_TPR_C  15 geYseArryvdalLei 30 
                 ++Y+ Ar+  + +++i
  EFC38999.1 438 KDYKAARQIFKKIINI 453
                 89******99988765 PP

>> DUF5113  Domain of unknown function (DUF5113)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.0     0.026        22      16      50 ..      18      52 ..       7      73 .. 0.83
   2 !    8.6   0.0    0.0018       1.5      10      46 ..      80     116 ..      76     128 .. 0.89
   3 ?   -0.1   0.1      0.82     7e+02      11      36 ..     116     141 ..     112     163 .. 0.87
   4 ?   -2.9   0.0         6   5.1e+03      95     119 ..     432     455 ..     422     469 .. 0.55

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.026
     DUF5113 16 yylnvegeyeeALeyldsaleylNahyekYakkka 50
                ++l+++g+++eA +y+d+ l++  +h e  ++k  
  EFC38999.1 18 SNLYAKGKFKEAADYFDKILDISPNHIEALYHKGV 52
                567899********************999999864 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0018
     DUF5113  10 dYanlayylnvegeyeeALeyldsaleylNahyekYa 46 
                 +Y+  +++ n +ge+++A+e++++ + + N+ ++  +
  EFC38999.1  80 AYVIKGNAFNERGEFKKAMETFQKCIAMTNRSFDVVY 116
                 699999************************9887655 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.82
     DUF5113  11 YanlayylnvegeyeeALeyldsale 36 
                 Y  l+++++ +++++++Le+ ++a+ 
  EFC38999.1 116 YNALGNCYFLQEDFNSSLETYNKAIA 141
                 88899999999999999999999986 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 6
     DUF5113  95 ylalkdkeaydYNnniYldllkllr 119
                  +a+   ++y+  ++i+ ++++ ++
  EFC38999.1 432 RVAIAV-KDYKAARQIFKKIINITN 455
                 444432.335555555555555544 PP

>> TPR_MalT  MalT-like TPR region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0       1.2   1.1e+03      91     110 ..      21      40 ..       7      61 .. 0.74
   2 ?   11.7   0.0   0.00014      0.12      37     112 ..      76     145 ..      42     150 .. 0.78
   3 ?   -1.9   0.0         2   1.7e+03     248     268 ..     432     452 ..     401     472 .. 0.55

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.2
    TPR_MalT  91 vaqGrLheAletyeqalqla 110
                  a+G+++eA++ + ++l   
  EFC38999.1  21 YAKGKFKEAADYFDKILDIS 40 
                 56666666666666666654 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00014
    TPR_MalT  37 lariaatavlGeasllqGdleaAlqalqeaeklarqadslhvallallqqaeilvaqGrLheAletyeqalqlate 112
                  +r+a+  + G a+  +G++++A +++q+ ++++   +++  +++  l  ++ ++ q ++  +lety++a++la +
  EFC38999.1  76 KHRWAY-VIKGNAFNERGEFKKAMETFQKCIAMT---NRSFDVVYNAL--GNCYFLQEDFNSSLETYNKAIALAID 145
                 455666.67799999*******999999999999...55666666666..78999999**************9976 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2
    TPR_MalT 248 rvllalgrydeAlellerLlk 268
                 rv +a  +y++A+++ +++++
  EFC38999.1 432 RVAIAVKDYKAARQIFKKIIN 452
                 333333333333333333332 PP

>> DUF2959  Protein of unknown function (DUF2959)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0     0.016        14      30      77 ..      22      70 ..      17      75 .. 0.83
   2 ?    6.5   0.0    0.0096       8.2      31      67 ..      91     127 ..      85     147 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.016
     DUF2959 30 akeqfksALerfkavvefdggeLekeyeklnkeyeese.kaaeevreri 77
                ak +fk+A + f+++++++  ++e+ y+k  ++y +++ ++a +v+e++
  EFC38999.1 22 AKGKFKEAADYFDKILDISPNHIEALYHKGVTHYVSANfSEAIKVEEKV 70
                899*************************998888776535677777776 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0096
     DUF2959  31 keqfksALerfkavvefdggeLekeyeklnkeyeese 67 
                 + +fk+A+e f++ +++ + +++ +y++l + y   e
  EFC38999.1  91 RGEFKKAMETFQKCIAMTNRSFDVVYNALGNCYFLQE 127
                 679**************************99886555 PP

>> NARP1  NMDA receptor-regulated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.1   0.00047       0.4     206     261 ..      24      79 ..       2      82 .. 0.87
   2 ?    2.0   0.0      0.09        77     193     229 ..      79     115 ..      78     145 .. 0.79
   3 ?   -1.9   0.0       1.4   1.2e+03      37      67 ..     423     453 ..     389     481 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00047
                 T-SHHHHHHHHHHHHH-TT-HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCTTT-HH CS
       NARP1 206 gsrekAleyidkaiehtptlvelyltKarilkhaGdlkkAaevmeearklDlaDRy 261
                 g+ ++A +y dk ++ +p+ +e  + K+  +  + ++++A++v e+  +lD + R+
  EFC38999.1  24 GKFKEAADYFDKILDISPNHIEALYHKGVTHYVSANFSEAIKVEEKVLQLDPKHRW 79 
                 566799**********************************************9997 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.09
                 HHHHHHHHHHHHHT-SHHHHHHHHHHHHH-TT-HHHH CS
       NARP1 193 wvlyflAqhydklgsrekAleyidkaiehtptlvely 229
                 w++      +++ g+ +kA+e+ +k+i+ t  + ++ 
  EFC38999.1  79 WAYVIKGNAFNERGEFKKAMETFQKCIAMTNRSFDVV 115
                 6666777788999999999999999999999988865 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.4
                 HHHHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       NARP1  37 klavketkaelllkLgrkeeAeatyeaLler 67 
                 ++  +   +++ +++++++ A+++++++++ 
  EFC38999.1 423 EIRSMIGVGRVAIAVKDYKAARQIFKKIINI 453
                 4444444567777777777777777777765 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0       0.3   2.5e+02      26      51 ..      25      50 ..      22      64 .. 0.70
   2 ?   -0.6   0.0       1.6   1.4e+03      16      31 ..      90     105 ..      86     108 .. 0.86
   3 ?   -1.2   0.0       2.7   2.3e+03      24      39 ..     234     249 ..     230     256 .. 0.85
   4 ?    3.1   0.0      0.12     1e+02      24      41 ..     403     420 ..     403     429 .. 0.75
   5 ?   -0.1   0.0       1.2     1e+03      22      39 ..     435     452 ..     430     459 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.3
         MIT 26 lYkealelLlqalk.ekneerrellre 51
                ++kea +++ ++l    n     l+++
  EFC38999.1 25 KFKEAADYFDKILDiSPN-HIEALYHK 50
                6899*******9983344.44444444 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.6
         MIT  16 nagnyeeAlelYkeal 31 
                 ++g++++A+e +++++
  EFC38999.1  90 ERGEFKKAMETFQKCI 105
                 6799999999999998 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 2.7
         MIT  24 lelYkealelLlqalk 39 
                 l+ ++eal+ +l++++
  EFC38999.1 234 LNRFSEALDCFLLIIQ 249
                 6678999**9999987 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.12
         MIT  24 lelYkealelLlqalkek 41 
                 ++ Y++a++ +  +l+ +
  EFC38999.1 403 IRHYQKAIDNFECGLQMN 420
                 578********9999843 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 1.2
         MIT  22 eAlelYkealelLlqalk 39 
                  A++ Yk a ++++++++
  EFC38999.1 435 IAVKDYKAARQIFKKIIN 452
                 589999999999999987 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0      0.17   1.5e+02      13      27 ..      23      37 ..      18      39 .. 0.86
   2 ?    2.1   0.1      0.34   2.9e+02       9      25 ..      87     103 ..      86     107 .. 0.84
   3 ?    2.8   0.1       0.2   1.7e+02       1      25 [.     114     138 ..     114     141 .. 0.88
   4 ?   -0.8   0.0       2.9   2.5e+03      14      24 ..     235     245 ..     231     249 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.17
         PPR 13 nGkleeAlelfkeMk 27
                +Gk++eA ++f++++
  EFC38999.1 23 KGKFKEAADYFDKIL 37
                7***********975 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.34
         PPR   9 gycknGkleeAlelfke 25 
                 ++   G++++A+e f++
  EFC38999.1  87 AFNERGEFKKAMETFQK 103
                 67778**********97 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.2
         PPR   1 vtynslIsgycknGkleeAlelfke 25 
                 v+yn+l ++y    ++   le +++
  EFC38999.1 114 VVYNALGNCYFLQEDFNSSLETYNK 138
                 79*********99999999988876 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 2.9
         PPR  14 GkleeAlelfk 24 
                 ++++eAl++f 
  EFC38999.1 235 NRFSEALDCFL 245
                 7899****996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       781  (0.0435607); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              21  [number of targets reported over threshold]
# CPU time: 0.71u 0.36s 00:00:01.06 Elapsed: 00:00:00.56
# Mc/sec: 2625.94
//
Query:       EFC39000.1  [L=458]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (458 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       568  (0.0316805); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 2585.89
//
Query:       EFC39001.1  [L=391]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (391 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2139  (0.119304); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.74u 0.34s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 2173.76
//
Query:       EFC39002.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.7e-75  252.4   0.0    5.4e-75  252.2   0.0    1.0  1  Pkinase         Protein kinase domain
      3e-34  118.5   0.0    3.9e-34  118.1   0.0    1.1  1  Pkinase_Tyr     Protein tyrosine kinase
    2.2e-06   26.9   0.5    6.3e-05   22.1   0.5    2.1  1  Haspin_kinase   Haspin like kinase domain
    0.00043   19.7   0.2    0.00066   19.1   0.2    1.2  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
     0.0031   16.9   0.3       0.27   10.5   0.0    2.3  2  Kinase-like     Kinase-like
     0.0042   16.7   0.1     0.0066   16.1   0.1    1.3  1  RIO1            RIO1 family
  ------ inclusion threshold ------
      0.011   15.7   0.0      0.021   14.7   0.0    1.4  1  APH             Phosphotransferase enzyme family
       0.11   12.1   0.1        0.2   11.2   0.1    1.4  1  Choline_kinase  Choline/ethanolamine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  252.2   0.0   2.4e-78   5.4e-75       1     264 []      29     314 ..      29     314 .. 0.91

  Alignments for each domain:
  == domain 1  score: 252.2 bits;  conditional E-value: 2.4e-78
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH.....HHSS CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle.....rkgs 94 
                 y+klek+GeG++G+Vyka +++tg+ivA+Kk++ e++++   ++ +rEi++lk+l+hpn+vrl +v++ +++l lv+e+++++  ++         k++
  EFC39002.1  29 YKKLEKVGEGTYGVVYKAEDTQTGQIVALKKVRLEQEDEGVPSTSIREISLLKELNHPNVVRLHQVIHCDQQLNLVFEFIDHDL-KKKTDyyrkvLKQT 126
                 7899*****************************************************************************884.44444443555678 PP

                 --HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHHHH CS
     Pkinase  95 lseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvl.keneyskkvDvWslGvilyell 191
                 ++++++k  + qil+g++++Hs++iiHrDlKp+NiLi+++g++K++DFGla+ ++  ++ lt++v+t +Y+APE+l ++++ys+++D+Ws+G+i++el 
  EFC39002.1 127 IPPQDVKTTLFQILKGIAFCHSQRIIHRDLKPQNILISSEGDIKLADFGLARAFQIPTRtLTHEVVTLWYRAPEILlGAKRYSTPIDLWSIGCIFAELC 225
                 999***************************************************998888****************99********************* PP

                 HSS-STTTSSHHHHHHHHHHTHHHHHHHCT.......SHH...HHHTTS......................-HHHHHHHHHHT-SSGCCSTTHHHHHTS CS
     Pkinase 192 tgkppfsgekgkekvekeldqlekilkilg.......etkeklpeasei......................seeakdllkkllkkdpkkRltaeellqh 261
                 tg+ +f+    +    +e+d l ki+++lg           +      +                       e  +dll ++l ++p+kR+ta+e+l+h
  EFC39002.1 226 TGQALFP---AD----SEIDMLYKIFQLLGtpsetvwSGVTS------LpnwkaifpnwrgnfigglvpnlCEAGIDLLGRMLIYQPNKRITAKEALEH 311
                 *******...33....37788888999999744433333344......4555555****************9*************************** PP

                 GGG CS
     Pkinase 262 pyl 264
                 +y+
  EFC39002.1 312 RYF 314
                 **8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.1   0.0   1.7e-37   3.9e-34       4     214 ..      32     239 ..      29     251 .. 0.87

  Alignments for each domain:
  == domain 1  score: 118.1 bits;  conditional E-value: 1.7e-37
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH.HHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTE..BHHHHHHHTCTT CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateee.keelleeakimkklkhpnivkllgvctkeepllivteyvkgG..dLlkfLrkkeke 98 
                   +k+GeG++G V++++ +    ++ + Va+K+++ e+++e   +  ++e++++k+l+hpn+v+l+ v+  +++l +v+e++++   +  ++ rk  k+
   EFC39002.1  32 LEKVGEGTYGVVYKAEDT----QTGQIVALKKVRLEQEDEGvPSTSIREISLLKELNHPNVVRLHQVIHCDQQLNLVFEFIDHDlkKKTDYYRKVLKQ 125
                  689************988....9999*******75555544388899**********************************996445567999999** PP

                  TSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.EEHHHHHHHHHHHH CS
  Pkinase_Tyr  99 kltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.ftsksDvWsfGvll 195
                  ++  +d+    +q+ kG+++ +s++++Hrdl  +N+L+s++  +k++DfGLar+   +  +++ +++ + + + apE+l   k +++  D Ws G + 
   EFC39002.1 126 TIPPQDVKTTLFQILKGIAFCHSQRIIHRDLKPQNILISSEGDIKLADFGLARAF--QIPTRTLTHEVVTLWYRAPEILLGAKrYSTPIDLWSIGCIF 221
                  *******************************************************..55556667778888888***9876555************** PP

                  HHHHTTSSGTTTTSHHHHH CS
  Pkinase_Tyr 196 wEiftlgespypglkneev 214
                   E++t g+  +p  ++ ++
   EFC39002.1 222 AELCT-GQALFPADSEIDM 239
                  ****9.8877776655555 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.1   0.5   2.8e-08   6.3e-05      81     257 ..      10     180 ..       3     208 .. 0.65

  Alignments for each domain:
  == domain 1  score: 22.1 bits;  conditional E-value: 2.8e-08
  Haspin_kinase  81 evilsqilelckikkilneadlasllndseklssevyqtke..kdkevvlKviplevledvtis...kelsl.kelkslklvkgtypglllllqdk 170
                    ++ +s++ +++ +++ l   ++++l + +e+ ++ vy++++  + + v+lK++ le  ++   s   +e+sl kel+  ++v+      ++ + ++
     EFC39002.1  10 QFSMSEKQQYSPVSQKL--LRYKKLEKVGEGTYGVVYKAEDtqTGQIVALKKVRLEQEDEGVPStsiREISLlKELNHPNVVRLH---QVIHCDQQ 100
                    55556666666665555..34555556699999*****999655677899*****777775544112222222444444444433...22222222 PP

  Haspin_kinase 171 vlkekpdfyseqqlflvlllkdkGtdLeev..klkswkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRle 257
                    ++            f+   lk+k +   +v  +    ++++  ++qi+k ++   ++ +  HRdL+ +niL+ +++ + l d+ l+R+ 
     EFC39002.1 101 LNLVF--------EFIDHDLKKKTDYYRKVlkQTIPPQDVKTTLFQILKGIAFCHSQ-RIIHRDLKPQNILISSEGDIKLADFGLARAF 180
                    22222........222223444444444445455666889999********999876.788**************************96 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.2     3e-07   0.00066      57     169 ..      72     177 ..      52     198 .. 0.83

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 3e-07
         Kdo  57 ravrEfrllkrLeeagvavpkpvaagavkvgleyrAlllterlegaqdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqee 155
                 ++ rE++llk+L++  v  +  v  + ++ +l +    +  +l++  d    + k ++++ +  +++l ++ + ia  h+  + H+dl ++nil+  e+
  EFC39002.1  72 TSIREISLLKELNHPNVVRLHQVIHCDQQLNLVFE--FIDHDLKKKTDYYRKVLK-QTIPPQDVKTTLFQILKGIAFCHSQRIIHRDLKPQNILISSEG 167
                 899**********************9999998875..788888888888777776.4555555566777899*************************99 PP

         Kdo 156 eeeaeiwliDldka 169
                      i l D+  a
  EFC39002.1 168 ----DIKLADFGLA 177
                 ....7777777555 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.1     0.015        34      14      50 ..      29      65 ..      19      82 .. 0.79
   2 !   10.5   0.0   0.00012      0.27     152     191 ..     138     177 ..     130     226 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.015
  Kinase-like 14 lvrgellkkgdrsvvfevkdqetgeplavkvfllpse 50
                 +++ e +++g  +vv++++d +tg+ +a+k   l++e
   EFC39002.1 29 YKKLEKVGEGTYGVVYKAEDTQTGQIVALKKVRLEQE 65
                 4566667888899****************98777664 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00012
  Kinase-like 152 qlirlaanLqakglvhgkftvdnllldekgglmlggftaL 191
                  q+++ +a  +++ ++h +++++n+l   +g ++l +f+  
   EFC39002.1 138 QILKGIAFCHSQRIIHRDLKPQNILISSEGDIKLADFGLA 177
                  666777888999************************9743 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.1     3e-06    0.0066      54     150 ..      72     175 ..      42     184 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 3e-06
                 HHHHHHHHHHHHHHTT.--S--EEEEETTE.EEEE--EETTEEGGB.H.HHCG-...HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETT.EE CS
        RIO1  54 waekEfrnLkrleeag.vpvPkpielkrhv.lvmefigedgvaapk.l.kdvee...eeeaeelyeevleemrklykeaglvHaDLSeyNvlvded.kv 144
                 +  +E++ Lk+l++ + v+  ++i++ ++  lv efi++d  + ++   k +++    ++ ++ + ++l+  +++ + ++++H DL   N+l++++ ++
  EFC39002.1  72 TSIREISLLKELNHPNvVRLHQVIHCDQQLnLVFEFIDHDLKKKTDyYrKVLKQtipPQDVKTTLFQILKG-IAFCHSQRIIHRDLKPQNILISSEgDI 169
                 56689999999998876899999999888659*****9554333221102222224478888888899985.66777****************999899 PP

                 EE--GT CS
        RIO1 145 viIDvs 150
                  + D++
  EFC39002.1 170 KLADFG 175
                 998886 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.0   9.6e-06     0.021     165     197 ..     148     178 ..      90     180 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 9.6e-06
                 -EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 165 ptvllHgDlhpgNllvdpddgrvtGviDfedag 197
                 +++++H+Dl+p+N+l+ ++++    + Df++a+
  EFC39002.1 148 SQRIIHRDLKPQNILISSEGDIK--LADFGLAR 178
                 689**************666555..78888876 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.1   8.8e-05       0.2     126     171 ..     111     174 ..      87     180 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 8.8e-05
                     HHHHHHHTHHHHHH.............CHGG-EEEE-S......--SGGGEEE.-CTTEEEE--G CS
  Choline_kinase 126 dlekelekleklle.............elespvvfcHn......DlqegNillnkeekklvlIDF 171
                     dl+k+++ ++k+l+             ++ + + fcH       Dl ++Nil  ++e+++ l DF
      EFC39002.1 111 DLKKKTDYYRKVLKqtippqdvkttlfQILKGIAFCHSqriihrDLKPQNILI-SSEGDIKLADF 174
                     56777777777775567777666666677777999964444444*********.9*********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 1806.67
//
Query:       EFC39003.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-10   40.0   0.0    1.6e-06   28.6   0.0    3.7  4  RCC1      Regulator of chromosome condensation (RCC1) repeat
      0.005   16.6   4.5        1.2    9.0   0.1    3.6  4  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.4   1.3e+04      24      33 ..      60      69 ..      45      75 .. 0.70
   2 ?    0.6   0.0       0.1     9e+02      34      50 .]     169     186 ..     156     186 .. 0.81
   3 !    5.7   0.0    0.0026        23       4      49 ..     192     238 ..     191     239 .. 0.70
   4 !   28.6   0.0   1.8e-10   1.6e-06       1      50 []     242     291 ..     242     291 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.4
                EEEEE-GGGT CS
        RCC1 24 lvPtkvegls 33
                ++Pt+v +++
  EFC39003.1 60 TKPTQVFLSK 69
                5699996665 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.1
                 TS.-EEEEEEETTEEEEE CS
        RCC1  34 gn.rvvkvacGddhtval 50 
                 +n + v+v  G+ h+ +l
  EFC39003.1 169 RNdELVDVKTGYGHSYFL 186
                 446899********9875 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0026
                 EEEEE--GGGTTSS.SS-.--EEEEEE-GGGTTS..-EEEEEEETTEEEE CS
        RCC1   4 VysWGrndyGqLGl.gtt.esvlvPtkveglsgn..rvvkvacGddhtva 49 
                 +y +G++ +GqL + g++ ++    tk+++++ +  rv+ +a+G   ++a
  EFC39003.1 192 LYFCGNSGFGQLACsGDRaHDM---TKISNSKIKgrRVKIIASGFANCLA 238
                 899**********955557666...7776655445577777777666665 PP

  == domain 4  score: 28.6 bits;  conditional E-value: 1.8e-10
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtval 50 
                 dG+ + WG+nd+ qLG  ++ + + P+ + ++s+n+++  ++G++ ++a+
  EFC39003.1 242 DGNGLVWGNNDHKQLGYEKHFCITNPKPLDLPSDNEIIGLSAGQNISLAM 291
                 566679**************99988999999****************996 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.14   1.3e+03      11      21 ..      92     102 ..      89     103 .. 0.85
   2 !    9.0   0.1   0.00014       1.2       2      30 .]     174     202 ..     174     202 .. 0.95
   3 !    6.8   0.2   0.00067         6       1      28 [.     226     253 ..     226     255 .. 0.88
   4 ?   -1.8   0.0      0.33     3e+03       3      15 ..     280     292 ..     278     299 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.14
      RCC1_2  11 scaLtedGeVl 21 
                  ++Lt+ G+++
  EFC39003.1  92 MIVLTRKGRIY 102
                 579******98 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00014
      RCC1_2   2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++v  G+ Hs +L+ + e++ +G+ ++GQ
  EFC39003.1 174 VDVKTGYGHSYFLDMNRELYFCGNSGFGQ 202
                 57889***********************9 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.00067
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsd 28 
                 Vk +++G    +a+ edG+ l WG+N++
  EFC39003.1 226 VKIIASGFANCLAVFEDGNGLVWGNNDH 253
                 566999999*****************87 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 0.33
      RCC1_2   3 svsaGdyHscaLt 15 
                  +saG + s+a+t
  EFC39003.1 280 GLSAGQNISLAMT 292
                 5799999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       459  (0.025601); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.24s 00:00:00.71 Elapsed: 00:00:00.42
# Mc/sec: 2447.06
//
Query:       EFC39004.1  [L=963]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.5e-13   48.3   1.1    1.9e-12   47.0   1.1    1.6  1  PI3Ka     Phosphoinositide 3-kinase family, accessory domain 
  ------ inclusion threshold ------
      0.085   12.4   8.0       0.21   11.1   0.4    3.1  3  LRR_9     Leucine-rich repeat
       0.16   12.5  20.9      0.061   13.8   2.9    6.0  4  LRR_4     Leucine Rich repeats (2 copies)
       0.23   11.3   9.6       0.23   11.2   1.2    3.9  4  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> PI3Ka  Phosphoinositide 3-kinase family, accessory domain (PIK domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.0   1.1   4.2e-16   1.9e-12      41     158 ..     553     669 ..     530     698 .. 0.85

  Alignments for each domain:
  == domain 1  score: 47.0 bits;  conditional E-value: 4.2e-16
                 CTSGGGHHHHHTTS-SSSHHHHHHHHHHHTTSHHTTHHHHTTTTSTTS--HHHHHHHHHHHHHSHHHHHHHHHHHHHHHHGGSSSSSSHHHHHHHH.HH CS
       PI3Ka  41 knnkkaltklLqsvkwseesevkealelldsWaeididdaLeLLdskfkdesvreyavkvLekasdeelllYllQLVqalkyepikdsalaefLlk.ra 138
                 +n++ +   +L  + +++     ea + l +W++ +i + ++L++ +    + +   +k+Le+ sd+ ++ +l+ LV ++kye  + ++lae+Llk r 
  EFC39004.1 553 MNEPSHFVPFLYGISFETPMIIYEANQTLGKWKKPNIIEMISLFSENIG-IFSKLVLIKCLEETSDDLFSDILPFLVHCIKYE-NEYGVLAEYLLKnRC 649
                 678888888999999999999999********************98854.55555679*************************.899********6489 PP

                 HHSHHHHHHHHHHHHHHHHC CS
       PI3Ka 139 lknkrlghfffWyLkseied 158
                 lk+k++g+++fW Lk+e+  
  EFC39004.1 650 LKSKLFGNQLFWLLKVESSY 669
                 *****************943 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.24   1.1e+03      58      96 ..      74     116 ..      60     146 .. 0.50
   2 ?    4.1   0.9    0.0064        29      63     127 ..     150     214 ..     136     247 .. 0.70
   3 ?   11.1   0.4   4.7e-05      0.21      33     103 ..     243     312 ..     235     367 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.24
       LRR_9  58 dgfPllkrlktlllnnnrivria....egleevlPnleelvlt 96 
                 +++ ++ +lk+l + +  i + +     + + +lPnl +l++ 
  EFC39004.1  74 NSISHFYKLKSLDIMESIIDNQEyyklMNSKMSLPNLVNLLVD 116
                 4444555555554333222221110002334556666666554 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.0064
       LRR_9  63 lkrlktlllnnnrivria.egleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 + +l  l  +n r + ++ ++l+++  nlee++l + ++++++++    ++++l +l++ + ++ +
  EFC39004.1 150 MTKLTHLEYSNLRKLSVNlKDLNRISNNLEEFILEQGNIENFSEFA-KCEFNNLVSLTISSKSIWK 214
                 678888888898888887579999999**********999999954.4677777777776665543 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 4.7e-05
       LRR_9  33 vienlGatldqfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqel 103
                 +i+n+   l+q+ ++d+ d  i  + +    k lk l +++nr++  a  + e +P+l  l ++n++l++ 
  EFC39004.1 243 LIKNIC-DLEQLTSLDVPDCGIDSIFEEYEWKNLKRLNISENRLCTKAISIIENMPSLIYLSMNNSRLKDH 312
                 566764.68999999******998755555699**********************************9975 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.4      0.23     1e+03      22      30 ..      79      87 ..      53     129 .. 0.61
   2 ?   -0.2   5.6      0.35   1.6e+03       1      42 [.     151     194 ..     149     225 .. 0.70
   3 ?   10.9   0.1   0.00011      0.48       2      35 ..     252     284 ..     251     288 .. 0.88
   4 ?   13.8   2.9   1.4e-05     0.061       1      38 [.     273     311 ..     273     315 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.23
                -TT--EEE- CS
       LRR_4 22 lpnLkeLdL 30
                + +Lk+Ld+
  EFC39004.1 79 FYKLKSLDI 87
                445555554 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.35
                 SS--EEE--SS---E-S-....HHH.-TT--EEE-..-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqltdipl....lek.lpnLkeLdL.sgNnlitdldeL 42 
                 ++L++L  sn  l++++     l+    nL+e+ L  gN  i++++e+
  EFC39004.1 151 TKLTHLEYSN--LRKLSVnlkdLNRiSNNLEEFILeQGN--IENFSEF 194
                 5788888888..777666533344423446666564444..6666555 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 0.00011
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnl 35 
                 +L++Ld  ++ + +i   +  +nLk L++s+N +
  EFC39004.1 252 QLTSLDVPDCGIDSIFEEYEWKNLKRLNISEN-R 284
                 69************999667*********999.3 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 1.4e-05
                 SS--EEE--SS-.--.E-S-HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNq.lt.diplleklpnLkeLdLsgNnlitd 38 
                 +nL+ L++s N+  t  i+ +e++p+L +L++ +N++++d
  EFC39004.1 273 KNLKRLNISENRlCTkAISIIENMPSLIYLSM-NNSRLKD 311
                 79*******99665558888889*********.8878876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       2.7   1.2e+04      24      31 ..      79      86 ..      75      89 .. 0.45
   2 ?   -0.3   0.3       0.2   9.1e+02      26      57 ..     177     208 ..     149     212 .. 0.66
   3 ?    2.2   0.2     0.035   1.6e+02       2      59 ..     201     261 ..     200     263 .. 0.72
   4 ?   11.2   1.2   5.2e-05      0.23       2      38 ..     274     310 ..     273     315 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 2.7
                -TT--EEE CS
       LRR_8 24 lsnLkvLd 31
                + +Lk+Ld
  EFC39004.1 79 FYKLKSLD 86
                33344443 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.2
                 T--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8  26 nLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 nL+++ L + +++ +s+ a   +++L sL++s
  EFC39004.1 177 NLEEFILEQGNIENFSEFAKCEFNNLVSLTIS 208
                 55555555656666665555555666666555 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.035
                 T-SEEE-TTS--SE..E-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrlts..lddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsgN 59 
                 nL sL +s+ ++++  l+  + ++  +Lk L++s   l+++   + + +L++L+sLd+ ++
  EFC39004.1 201 NLVSLTISSKSIWKdfLETITEFKPLKLKRLKISTFgLIDFHLIKNICDLEQLTSLDVPDC 261
                 6788888888877611444444446688999999998888755689999999999998766 PP

  == domain 4  score: 11.2 bits;  conditional E-value: 5.2e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 nL++L++s Nrl     +  +++++L +L+++n +l+
  EFC39004.1 274 NLKRLNISENRLCTKAISIIENMPSLIYLSMNNSRLK 310
                 8999999999999999999999999999999998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (963 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       613  (0.0341904); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.78u 0.30s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 5575.51
//
Query:       EFC39005.1  [L=337]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.9e-24   86.4   0.0    4.1e-24   85.3   0.0    1.5  1  DUF676        Putative serine esterase (DUF676)
    1.3e-05   25.1   0.0    4.2e-05   23.4   0.0    1.8  2  Lipase_3      Lipase (class 3)
     0.0011   18.8   0.1     0.0026   17.5   0.0    1.7  2  PGAP1         PGAP1-like protein
  ------ inclusion threshold ------
      0.012   15.5   0.0      0.028   14.2   0.0    1.8  1  Palm_thioest  Palmitoyl protein thioesterase
       0.08   13.1   0.1        2.7    8.2   0.0    2.6  3  DUF432        Protein of unknown function (DUF432)


Domain annotation for each model (and alignments):
>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.3   0.0   1.1e-27   4.1e-24      32     213 ..      20     198 ..       5     206 .. 0.84

  Alignments for each domain:
  == domain 1  score: 85.3 bits;  conditional E-value: 1.1e-27
      DUF676  32 keklpeekieflmsennesktfkgidvlgerlaeevlevvkkkkdk.......nkkiSfvghSlGgliaraaiaklkekemtlkeaikglepvtfitla 123
                 ++ lp++++  l  + n+++t++g+ v g+r+a+e++e+++k+          + k S++ghSlGgl  r+a  +l ++ +  +e+ k  ep+ ++t+ 
  EFC39005.1  20 DSILPDDQLFTLRPSSNSKDTHHGVAVGGKRMAQEIIEYFRKEILPkfternnKVKFSLIGHSLGGLYCRYAAYVLMNEYE--DEFSKYFEPIGLTTIC 116
                 6778999999999999*************************99877788888888*****************987775544..5566899********* PP

      DUF676 124 sPhLGvlyssksl.inlglalleklkkslsmeqlgltGrdLflkddkdeknsllykllkdekdlkliealklFkrrvlyanvvndrivpla 213
                 sPhLG+   s+     l  ++++ ++++ + + lg tG++L l        +ll+++++ e+  k+i+a + Fk  +l++++ ++ i + +
  EFC39005.1 117 SPHLGSKRTSSGGwTDLYGNVVSTIANTYVGHFLGDTGKQLALS------DPLLMEMSEPES--KFISAWNSFKFKTLIGST-HYDISVPH 198
                 *****97766664155667899*******************999......79*****66665..****************88.55555444 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.4   0.0   1.2e-08   4.2e-05      40     112 ..      49     125 ..      24     140 .. 0.78
   2 ?   -3.3   0.0       2.1   7.6e+03      65      73 ..     217     225 ..     212     225 .. 0.80

  Alignments for each domain:
  == domain 1  score: 23.4 bits;  conditional E-value: 1.2e-08
                 HHHHHS-HHHHHHHHHHH.HHHHTT-EEEEEEEETHHHHHHHHHHHHHHHTT-SS....---EEEEEES----B-HHH CS
    Lipase_3  40 leayeeslreqvlkelkr.llekypeysivvtGHSLGgalAlLaaldlvengene....kkkvtvvtfGqPrvgnkef 112
                  ++++  + e ++ke+     e+++++++ + GHSLGg     aa++l +++e e     +++++ t+ +P  g+k+ 
  EFC39005.1  49 KRMAQ-EIIEYFRKEILPkFTERNNKVKFSLIGHSLGGLYCRYAAYVLMNEYEDEfskyFEPIGLTTICSPHLGSKRT 125
                 44555.45555555554438999999**************************9999998899***********99875 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 2.1
                 EEEEEEEET CS
    Lipase_3  65 ysivvtGHS 73 
                 +++ ++GHS
  EFC39005.1 217 IEFSIVGHS 225
                 7899****9 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.0   7.3e-07    0.0026      60     157 ..      46     147 ..      36     185 .. 0.77
   2 ?   -3.9   0.1       2.5   9.1e+03      43      58 ..     239     254 ..     231     259 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 7.3e-07
       PGAP1  60 ldGrtlldqaeylndaIkyIlslysssekeptsviliGHSmGGivaraa.ltlknyikqsvnt......iltlasPhalpplsfdkdilklyervnefw 151
                 + G+ +   +e +++  k+Il  + ++++++ +  liGHS+GG+  r a  +l n  +++ ++      + t+ sPh  +  +  +  ++ly +v +  
  EFC39005.1  46 VGGKRMA--QEIIEYFRKEILPKF-TERNNKVKFSLIGHSLGGLYCRYAaYVLMNEYEDEFSKyfepigLTTICSPHLGSKRTSSGGWTDLYGNVVSTI 141
                 5555565..677777788899999.777888899************9652445553344444312222267999******************9999887 PP

       PGAP1 152 kkelee 157
                  + ++ 
  EFC39005.1 142 ANTYVG 147
                 777655 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 2.5
       PGAP1  43 kkeldfftvdfneels 58 
                  keldf   df+e + 
  EFC39005.1 239 DKELDFQVEDFDESIE 254
                 4679999999999875 PP

>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   7.9e-06     0.028      61     109 ..      61     131 ..      33     283 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 7.9e-06
  Palm_thioest  61 k........lelangfhaiGfSQGglflRaliercddkkn........vrnlislggpqaGvfg......l 109
                   k         +++ +f +iG+S Ggl +R  +    ++ +           l ++++p+ G          
    EFC39005.1  61 KeilpkfteRNNKVKFSLIGHSLGGLYCRYAAYVLMNEYEdefskyfePIGLTTICSPHLGSKRtssggwT 131
                   234444444567899**************876554333224566887756788999999998774444330 PP

>> DUF432  Protein of unknown function (DUF432)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.0   0.00075       2.7      57      84 ..      72      99 ..      60     109 .. 0.83
   2 ?   -3.0   0.0       2.2   8.1e+03      33      55 ..     214     237 ..     203     241 .. 0.63
   3 ?    1.8   0.0     0.073   2.6e+02      88     122 ..     258     292 ..     248     293 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00075
      DUF432 57 skkkYaLYGspesGviaryvksevysep 84
                +k+k++L G+   G  +ry+   +++e 
  EFC39005.1 72 NKVKFSLIGHSLGGLYCRYAAYVLMNEY 99
                799****************987777665 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.2
      DUF432  33 kvpveigvf.ikskkeveliDvfs 55 
                 k p+e +++  +  ++ +  D+f+
  EFC39005.1 214 KGPIEFSIVgHSGFDSDNYSDIFT 237
                 457777777555666666666666 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.073
      DUF432  88 dpleeavveleikNetdevvevskivfdalglkly 122
                 d+ +e +++ ++ N+ ++ v+ ++i ++ ++ ++y
  EFC39005.1 258 DSSNENLISTKMLNNLQKHVNCRRIHIQFSYPSFY 292
                 56678899999*****************9999999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (337 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       712  (0.0397122); expected 358.6 (0.02)
Passed bias filter:                      480  (0.0267723); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.41
# Mc/sec: 2453.65
//
Query:       EFC39006.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1418  (0.0790897); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 2831.12
//
Query:       EFC39007.1  [L=473]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-24   85.8   5.7    8.1e-07   29.0   0.2    6.1  6  Kelch_4   Galactose oxidase, central domain
    3.9e-19   68.2  11.3    4.3e-05   23.6   0.0    6.2  6  Kelch_6   Kelch motif
    5.1e-16   58.5   0.5     0.0042   17.3   0.1    5.7  6  Kelch_3   Galactose oxidase, central domain
    1.2e-13   50.4   9.2     0.0003   20.3   0.4    5.0  5  Kelch_1   Kelch motif
    1.6e-11   43.7  11.0    0.00025   20.9   0.3    6.1  6  Kelch_2   Kelch motif
    2.3e-09   37.1  11.9    0.00045   20.2   0.3    5.5  6  Kelch_5   Kelch motif
  ------ inclusion threshold ------
        4.4    5.4  12.0        5.3    5.1  12.0    1.0  1  Nop14     Nop14-like family


Domain annotation for each model (and alignments):
>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.24   6.2e+02       9      26 ..     136     159 ..     131     182 .. 0.69
   2 !   29.0   0.2   3.2e-10   8.1e-07       4      42 ..     187     227 ..     186     232 .. 0.95
   3 !   23.9   0.1   1.2e-08   3.2e-05      12      48 ..     254     291 ..     243     291 .. 0.84
   4 !   10.5   0.0   0.00019      0.48       2      44 ..     295     340 ..     294     351 .. 0.88
   5 !   16.1   0.0   3.2e-06    0.0082       6      43 ..     358     396 ..     353     403 .. 0.85
   6 ?    2.3   0.1     0.068   1.7e+02       6      30 ..     411     435 ..     405     440 .. 0.66

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.24
     Kelch_4   9 sipd...gtiylfGGrgedg...t 26 
                  +++     iy +GGr  dg   +
  EFC39007.1 136 IVDNhhsRIIYSWGGRDHDGiefQ 159
                 555533358999999999874443 PP

  == domain 2  score: 29.0 bits;  conditional E-value: 3.2e-10
     Kelch_4   4 ghsatsipd.gtiylfGGrgedg.tllndlylldlstntWr 42 
                 +hs+ ++p  +++y++GG+ +d+ t+ ndl +++l tn+W+
  EFC39007.1 187 YHSLNYNPVnNSFYIIGGIRNDDsTPENDLTIYNLDTNEWK 227
                 9******9978********99988****************6 PP

  == domain 3  score: 23.9 bits;  conditional E-value: 1.2e-08
     Kelch_4  12 dgtiylfGGrgedgtllndlylldlstntW.rrl.gslP 48 
                 ++ti+lfGG++++  +++dly++d +t tW +++ ++ P
  EFC39007.1 254 NNTIVLFGGYSDE-WISKDLYVFDCETETWvEKIvPNIP 291
                 59**********9.7***************866667766 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 0.00019
     Kelch_4   2 Raghsatsipd.gtiylfGGrgedg..tllndlylldlstntWrrl 44 
                 R + +a+++p+ ++ +++ G+ + +   l  dl ++ ++tn+W+ +
  EFC39007.1 295 RSFSTAVYNPSnDSMVIYAGELNIDvpVLTCDLVIFHFKTNSWTVV 340
                 8899*****6659************9999999999********987 PP

  == domain 5  score: 16.1 bits;  conditional E-value: 3.2e-06
     Kelch_4   6 satsipdgtiylfGGrgedg.tllndlylldlstntWrr 43 
                 +++ i+   +   GG+   +  + nd+y++dl+ n+W+ 
  EFC39007.1 358 TICLIDQRFLLSLGGCEQSNrIPKNDCYVFDLKRNEWSV 396
                 667777788888899988878999*************85 PP

  == domain 6  score: 2.3 bits;  conditional E-value: 0.068
     Kelch_4   6 satsipdg.tiylfGGrgedgtllnd 30 
                 s++ +  g  +y +GG +e++ ++ d
  EFC39007.1 411 SLVHDATGsGLYFYGGKTEED-VSTD 435
                 3444544349*********97.4443 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0    0.0012       3.2       5      40 ..     132     168 ..     129     173 .. 0.83
   2 !   23.6   0.0   1.7e-08   4.3e-05       5      44 ..     188     230 ..     184     236 .. 0.85
   3 !   22.8   0.1   3.1e-08     8e-05       8      48 ..     251     292 ..     245     295 .. 0.84
   4 ?    4.0   0.1     0.026        67      29      43 ..     326     340 ..     294     345 .. 0.80
   5 !   11.1   0.0   0.00015      0.39       4      42 ..     356     396 ..     353     399 .. 0.88
   6 ?    0.2   0.0       0.4     1e+03      10      22 ..     417     429 ..     406     437 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0012
     Kelch_6   5 hslvsvggk....iYifGGytdsspylnkvwvydpetksW 40 
                 h++ +v+++    iY +GG++++      +++yd+  k+W
  EFC39007.1 132 HTTEIVDNHhsriIYSWGGRDHD---GIEFQRYDILEKKW 168
                 67766777557789******997...699*******9999 PP

  == domain 2  score: 23.6 bits;  conditional E-value: 1.7e-08
     Kelch_6   5 hslvs..vggkiYifGGytds.spylnkvwvydpetksWeqlp 44 
                 hsl    v++++Yi+GG  ++ s++ n++ +y+++t+ W+  p
  EFC39007.1 188 HSLNYnpVNNSFYIIGGIRNDdSTPENDLTIYNLDTNEWKYFP 230
                 666443499*********8888*****************9755 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 3.1e-08
     Kelch_6   8 vsvggkiYifGGytdsspylnkvwvydpetksWeq..lpplpv 48 
                  s +++i++fGGy+d +  +++++v+d+et +W +  +p +p+
  EFC39007.1 251 RSFNNTIVLFGGYSDEW-ISKDLYVFDCETETWVEkiVPNIPI 292
                 5799***********65.45899**********9988888875 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.026
     Kelch_6  29 kvwvydpetksWeql 43 
                 ++ +++++t+sW+ +
  EFC39007.1 326 DLVIFHFKTNSWTVV 340
                 6789********975 PP

  == domain 5  score: 11.1 bits;  conditional E-value: 0.00015
     Kelch_6   4 ghslvsvgg.kiYifGGytds.spylnkvwvydpetksWeq 42 
                 g+++++++  ++  +GG  +s   + n+ +v+d++ + W+ 
  EFC39007.1 356 GNTICLIDQrFLLSLGGCEQSnRIPKNDCYVFDLKRNEWSV 396
                 678888887689999**9999******************96 PP

  == domain 6  score: 0.2 bits;  conditional E-value: 0.4
     Kelch_6  10 vggkiYifGGytd 22 
                  g+ +Y +GG t 
  EFC39007.1 417 TGSGLYFYGGKTE 429
                 3479******986 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0      0.11   2.8e+02      22      47 ..     159     191 ..     144     192 .. 0.70
   2 !   17.3   0.1   1.7e-06    0.0042       1      32 [.     196     227 ..     196     241 .. 0.90
   3 !   16.2   0.0   3.8e-06    0.0098       1      47 [.     254     301 ..     254     302 .. 0.81
   4 ?   -2.8   0.0       3.3   8.4e+03       1      11 [.     306     316 ..     306     318 .. 0.86
   5 !   14.7   0.0   1.1e-05     0.029       5      34 ..     368     397 ..     365     413 .. 0.80
   6 ?    0.1   0.0      0.41   1.1e+03       4      15 ..     421     430 ..     419     436 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.11
     Kelch_3  22 yvydldtntWaei......aslpp.aRaghaat 47 
                  +yd+   +W         +++pp a ++h++ 
  EFC39007.1 159 QRYDILEKKWLPPigmkesDDSPPnALYYHSLN 191
                 5677766778833344455778888*****986 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 1.7e-06
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWa 32 
                 ++++yi+GG + d  +++nd+  y+ldtn+W+
  EFC39007.1 196 NNSFYIIGGIRNDDSTPENDLTIYNLDTNEWK 227
                 699********6557777*************7 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 3.8e-06
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaei..aslpp.aRaghaat 47 
                 ++++++fGG+ d  +  ++d+yv+d +t+tW e   ++ p   R++ +a+
  EFC39007.1 254 NNTIVLFGGYSD--EWISKDLYVFDCETETWVEKivPNIPIeSRSFSTAV 301
                 799********5..7789**************777999876366665554 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 3.3
     Kelch_3   1 gdrlyifGGlg 11 
                 +d+++i+ G+ 
  EFC39007.1 306 NDSMVIYAGEL 316
                 689****9986 PP

  == domain 5  score: 14.7 bits;  conditional E-value: 1.1e-05
     Kelch_3   5 yifGGlgddgqdrlndvyvydldtntWaei 34 
                 +  GG+  +++ + nd yv+dl +n+W  +
  EFC39007.1 368 LSLGGCEQSNRIPKNDCYVFDLKRNEWSVC 397
                 56799**999*****************866 PP

  == domain 6  score: 0.1 bits;  conditional E-value: 0.41
     Kelch_3   4 lyifGGlgddgq 15 
                 ly++GG++   +
  EFC39007.1 421 LYFYGGKT--EE 430
                 8******9..44 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.44   1.1e+03      30      39 ..     159     168 ..     157     170 .. 0.89
   2 !   19.6   0.1     2e-07   0.00052      10      42 ..     195     229 ..     194     230 .. 0.94
   3 !   20.3   0.4   1.2e-07    0.0003      10      41 ..     253     284 ..     251     285 .. 0.95
   4 ?    1.9   0.0     0.064   1.6e+02      26      42 ..     324     340 ..     312     341 .. 0.84
   5 !   10.0   0.1   0.00019      0.49      23      41 ..     378     396 ..     370     397 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.44
                 EEEETTTTEE CS
     Kelch_1  30 evyDpetntW 39 
                  +yD  +++W
  EFC39007.1 159 QRYDILEKKW 168
                 69******** PP

  == domain 2  score: 19.6 bits;  conditional E-value: 2e-07
                 ETTEEEEEEEBCS..SSBEEEEEEEETTTTEEEEE CS
     Kelch_1  10 vggkiYviGGsdg..gnalssvevyDpetntWrel 42 
                 v++  Y+iGG ++  +++ +++ +y++ tn+W + 
  EFC39007.1 195 VNNSFYIIGGIRNddSTPENDLTIYNLDTNEWKYF 229
                 79999***************************975 PP

  == domain 3  score: 20.3 bits;  conditional E-value: 1.2e-07
                 ETTEEEEEEEBCSSSBEEEEEEEETTTTEEEE CS
     Kelch_1  10 vggkiYviGGsdggnalssvevyDpetntWre 41 
                 +++ i  +GG+++   +++++v+D+et tW e
  EFC39007.1 253 FNNTIVLFGGYSDEWISKDLYVFDCETETWVE 284
                 79****************************86 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.064
                 EEEEEEEETTTTEEEEE CS
     Kelch_1  26 lssvevyDpetntWrel 42 
                 ++++ ++ ++tn+W+ +
  EFC39007.1 324 TCDLVIFHFKTNSWTVV 340
                 66777899******987 PP

  == domain 5  score: 10.0 bits;  conditional E-value: 0.00019
                 SSBEEEEEEEETTTTEEEE CS
     Kelch_1  23 gnalssvevyDpetntWre 41 
                   + ++++v+D++ n+W+ 
  EFC39007.1 378 RIPKNDCYVFDLKRNEWSV 396
                 56789************97 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.1     0.009        23      13      42 ..     144     168 ..     141     174 .. 0.85
   2 !   12.3   0.0   4.9e-05      0.13      10      43 ..     195     227 ..     184     230 .. 0.82
   3 !   20.9   0.3   9.9e-08   0.00025       4      45 ..     245     285 ..     242     288 .. 0.84
   4 ?    3.4   0.0     0.033        85      29      45 ..     324     340 ..     304     341 .. 0.89
   5 ?    3.5   0.0      0.03        77      18      47 ..     371     399 ..     355     401 .. 0.73
   6 ?   -0.5   0.1      0.56   1.4e+03       7      19 ..     409     426 ..     405     440 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.009
     Kelch_2  13 kiyvvGGahtdnpnlsssdvhvldlekhvW 42 
                  iy++GG+     ++  + ++ +d  +++W
  EFC39007.1 144 IIYSWGGR-----DHDGIEFQRYDILEKKW 168
                 59******.....88888888888888888 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 4.9e-05
     Kelch_2  10 pggkiyvvGGahtdnpnlsssdvhvldlekhvWe 43 
                 +++  y++GG+ + +++   +d+ +++l++++W+
  EFC39007.1 195 VNNSFYIIGGI-RNDDSTPENDLTIYNLDTNEWK 227
                 48999******.66666667999**********8 PP

  == domain 3  score: 20.9 bits;  conditional E-value: 9.9e-08
     Kelch_2   4 ghsss..vpggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 gh+s+  + ++ i+++GG+    + + s d++v+d+e+++W e 
  EFC39007.1 245 GHVSVyrSFNNTIVLFGGY---SDEWISKDLYVFDCETETWVEK 285
                 566662245999*******...*******************875 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.033
     Kelch_2  29 ssdvhvldlekhvWeev 45 
                 ++d+ ++ +++++W+ v
  EFC39007.1 324 TCDLVIFHFKTNSWTVV 340
                 57999*********976 PP

  == domain 5  score: 3.5 bits;  conditional E-value: 0.03
     Kelch_2  18 GGahtdnpnlsssdvhvldlekhvWeevtp 47 
                 GG  ++ +    +d +v+dl+ ++W+ + +
  EFC39007.1 371 GGC-EQSNRIPKNDCYVFDLKRNEWSVCIQ 399
                 555.555555568899*********97666 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 0.56
     Kelch_2   7 ssvp.....ggkiyvvGG 19 
                 +s++     g+ +y++GG
  EFC39007.1 409 CSSLvhdatGSGLYFYGG 426
                 444455777999*****9 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.019        49       2      28 ..     126     155 ..     126     163 .. 0.79
   2 !    7.9   0.3    0.0012       3.1       2      42 .]     182     224 ..     181     224 .. 0.87
   3 !   20.2   0.3   1.7e-07   0.00045       3      41 ..     241     279 ..     239     280 .. 0.87
   4 ?   -2.4   0.0         2   5.2e+03       6      22 ..     295     314 ..     290     314 .. 0.53
   5 ?    0.2   0.0      0.31   7.8e+02      22      40 ..     372     390 ..     350     392 .. 0.72
   6 !    7.9   0.1    0.0012         3      15      35 ..     419     437 ..     407     440 .. 0.67

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.019
     Kelch_5   2 PppRaghcavtvsek....iYvyGGkvgrdg 28 
                 P +++ h + +v++     iY +GG+++ dg
  EFC39007.1 126 PLSIYAHTTEIVDNHhsriIYSWGGRDH-DG 155
                 899******8876333688999****96.54 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0012
     Kelch_5   2 PppRaghcavtv..sekiYvyGGkvgrdgsvs..ddvyvLdlpsf 42 
                 P+++++h+  +   +++ Y++GG+   +++++  +d+ +++l ++
  EFC39007.1 182 PNALYYHSLNYNpvNNSFYIIGGIR--NDDSTpeNDLTIYNLDTN 224
                 999*******97447**********..7777778*******9987 PP

  == domain 3  score: 20.2 bits;  conditional E-value: 1.7e-07
     Kelch_5   3 ppRaghcavtvs..ekiYvyGGkvgrdgsvsddvyvLdlps 41 
                 p+++gh +v+ s  + i ++GG++  d+ +s d+yv+d ++
  EFC39007.1 241 PGIYGHVSVYRSfnNTIVLFGGYS--DEWISKDLYVFDCET 279
                 459********85477********..9**********9865 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 2
     Kelch_5   6 aghcavtvs...ekiYvyGG 22 
                 +++++++++   +++ +y G
  EFC39007.1 295 RSFSTAVYNpsnDSMVIYAG 314
                 44555555334477777766 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.31
     Kelch_5  22 GkvgrdgsvsddvyvLdlp 40 
                 G  +++ ++ +d yv+dl+
  EFC39007.1 372 GCEQSNRIPKNDCYVFDLK 390
                 555556667799***9996 PP

  == domain 6  score: 7.9 bits;  conditional E-value: 0.0012
     Kelch_5  15 ekiYvyGGkvgrdgsvsddvy 35 
                 + +Y+yGGk+  +++vs d  
  EFC39007.1 419 SGLYFYGGKT--EEDVSTDSI 437
                 449*******..677776654 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1  12.0    0.0021       5.3     310     410 ..      13     120 ..       1     143 [. 0.52

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0021
       Nop14 310 kkke....asaDdldddfvleeeeeeeefglgkglka.........taeeeeeededdfeedddlveseseeee.eeeeedeeeeedeeeeeeeeeded 394
                 +++e    +  D  +d+ v  e  + ++        a          +++ ++++ +d+++ddd+v+ + + e  eee+ +   +++e++ +e++++ +
  EFC39007.1  13 SSEEiiaiPDDDKQEDEHVDIEFITYRHT-------AlcpiyypliYRQNFSKRNYEDKDHDDDDVALQVTLEIvEEEDHNHHHQDEESSTSESKHSVH 104
                 33334543322333333332232222222.......123344467644456888888888899999999999885555555555555555555555555 PP

       Nop14 395 dlsdleseeeeeedel 410
                 + s++e++ ++++d+ 
  EFC39007.1 105 EGSEDEKHRDQKSDQA 120
                 5454444433443333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (473 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1058  (0.0590105); expected 358.6 (0.02)
Passed bias filter:                      596  (0.0332422); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 2739.40
//
Query:       EFC39008.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-12   48.1   1.4    3.2e-12   47.4   1.4    1.4  1  Metallophos    Calcineurin-like phosphoesterase
    1.6e-09   38.1   0.0    4.1e-09   36.9   0.0    1.6  1  Metallophos_2  Calcineurin-like phosphoesterase superfamily d


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.4   1.4   3.6e-16   3.2e-12       1     204 []      56     245 ..      56     245 .. 0.73

  Alignments for each domain:
  == domain 1  score: 47.4 bits;  conditional E-value: 3.6e-16
                  EEEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSSHHHHHHHHHHHHHHHH....TSEEEEEC-TTSCHHHHHHHHHHHHHHHHHH CS
  Metallophos   1 lrilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrgdlekellellaalvky....pipvylllGNHegfeeellnkygylgifsep 94 
                  +++++i+D+H      ++++ ++l          d++l++GD++++g + + +  ++++l+k+     + ++++ GNHe ++ ++    +++++f e 
   EFC39008.1  56 MKFVLISDTH------CMHEMVDLP-------AGDVLLHCGDFTNTGLFTE-VDTFFEYLIKQcdgvFKYIIMIVGNHE-WSPDIIVYPRFQKYFREE 138
                  7999******......777777755.......78*************5555.6666666666544432235********.999999999999999777 PP

                  HEHHHCEEETSEEEEEETTEEEEEEEESECEEETHHHHHHHHHHHSCHHHHCC...HHHHHHHHHHTTCSEEEEEESSESS......CSSSCSCCHHH CS
  Metallophos  95 wrsdaevfnnlplaslgsgslkvlllhGgspellvsldklgslnleleapepg...dewlkdlekrekadwvivlgHsply......rgsgylfgdea 183
                  + + + + +++ l +      +++ ++++         k++++ ++ +++ p    +     ++   ++d++i+++H p        +++g + g+e+
   EFC39008.1 139 KSKSTLKSQYYLLLDESV---TIVDDNNH-------SIKIHGVRYRGNWAPPLfckK-----TSFNIPNDIDILMTHFPCCkfnmdrTSNGSSRGSEE 221
                  766655555555555222...45555555.......344455556666666444442.....33334667**********9***************** PP

                  HHHHHHHTT...ESEEEEESSSSE CS
  Metallophos 184 ledllkkyg...vdlvisGHtHvy 204
                  l +ll+ +    +++ ++GH H++
   EFC39008.1 222 LTTLLDSNHftnLKVHCFGHNHCP 245
                  **9999999999**********86 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.9   0.0   4.5e-13   4.1e-09       1     148 [.      56     268 ..      56     275 .. 0.71

  Alignments for each domain:
  == domain 1  score: 36.9 bits;  conditional E-value: 4.5e-13
  Metallophos_2   1 MklaiiSDlHsnldaleavlealkevgvdaiihaGDl.eeeepevleellela.........pvlaVrGNnD........................ 62 
                    Mk+++iSD+H  +++   +     +   d ++h+GD+ +++ ++ +++++e +          ++++ GN++                        
     EFC39008.1  56 MKFVLISDTH-CMHEMVDL----PAG--DVLLHCGDFtNTGLFTEVDTFFEYLikqcdgvfkYIIMIVGNHEwspdiivyprfqkyfreekskstl 144
                    **********.33333333....344..89*******99999999999999889999***999************999998886666555555555 PP

  Metallophos_2  63 .........eev.veedvlreaaelgtdl.........peeaelel...agekvlliHgdpl.............gvkdalaellkeaeegsd.vv 122
                             e v +++d  ++ + +g ++            ++ ++   ++ ++l++H                 +++++l+ ll+++  ++  v 
     EFC39008.1 145 ksqyyllldESVtIVDDNNHSIKIHGVRYrgnwapplfC--KKTSFnipNDIDILMTHFP-CckfnmdrtsngssRGSEELTTLLDSNHFTNLkVH 237
                    555555554222344444444444444445555553331..2222222355557777775.369*******99999999999999985444446** PP

  Metallophos_2 123 vcGHtHvp.....evekeggvlvvnPGsvge 148
                    ++GH H p       eke +++++n+ sv +
     EFC39008.1 238 CFGHNHCPkargfAYEKESDRMYINAISVIG 268
                    ********8888878888899*****99966 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       392  (0.021864); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.34s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1639.64
//
Query:       EFC39009.1  [L=585]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.4e-08   32.4  10.1    1.4e-07   31.5  10.1    1.5  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.5  10.1   7.8e-12   1.4e-07       2      39 ..      41      77 ..      40      79 .. 0.86

  Alignments for each domain:
  == domain 1  score: 31.5 bits;  conditional E-value: 7.8e-12
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                aC++Crk + KCd+k   Cs+C  +++eC++++ ++ r
  EFC39009.1 41 ACIRCRKLHKKCDKKLSGCSKCLAVGSECVYNTPQK-R 77
                9*************8888************555544.4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (585 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       921  (0.0513693); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 3386.64
//
Query:       EFC39010.1  [L=222]
Description: oxidoreductase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      2e-08   35.0   0.0      3e-08   34.4   0.0    1.3  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
      0.022   15.4   0.1      0.059   14.0   0.1    1.8  1  2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
      0.052   12.5   0.0      0.073   12.1   0.0    1.1  1  PAD             Protein-arginine deiminase (PAD)


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.4   0.0   5.1e-12     3e-08       3      81 ..     114     201 ..     112     213 .. 0.86

  Alignments for each domain:
  == domain 1  score: 34.4 bits;  conditional E-value: 5.1e-12
                     EEEE-TT-EEEEE-SS--............--TT.-.EEEEEEEEE....ET-B--EEE...........---TT-EEEEE-..B-TEEE-- CS
  2OG-FeII_Oxy_3   3 vlrygegqeykpHvDnfe............keegsgqrrltvllyLnekeseeGGelelyekdk.eavkikpkkgrlvlFesdellpHevlp 81 
                     +++y +g+++ pH+D +             k +  ++  +tvllyLn  + e+GGe  + +++   ++++kp++g++++F  ++   He++ 
      EFC39010.1 114 FYKYAAGEYFAPHYDGCFqrptlnveingkKMKVVERSFITVLLYLN--DVESGGETNFLNSRCeITHSVKPQAGQVLMFVHSNY--HEGSV 201
                     789999*********9889********998666667899*******8..5699***9998877789***************9777..99875 PP

>> 2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.1   9.8e-06     0.059      22      73 ..     150     198 ..     112     213 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 9.8e-06
  2OG-FeII_Oxy_4  22 eRrvayilyleeeWkeddGGaLllsddegdvtksivPkwnqlvlFevkeshs 73 
                     + +++++lyl+   + + GG+ ++ ++++++t+s+ P+ +q+ +F  ++ h+
      EFC39010.1 150 RSFITVLLYLN---DVESGGETNFLNSRCEITHSVKPQAGQVLMFVHSNYHE 198
                     44566677776...5799***************************7665564 PP

>> PAD  Protein-arginine deiminase (PAD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   1.2e-05     0.073     212     279 ..      27      96 ..      19      99 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.2e-05
                 EEEHHHHHHHHHHCCCTTTTT-EETTTS......TTS--EECHHHHC-CCHHHH.HHHHHHHHHHHHHHHH CS
         PAD 212 laspsaclellrekkkeghgdvklfsglsk..aekevekvtinelLadeslike.nayvqkkidknreilk 279
                 l s+++c +ll+e ++ g+g++++ +g+++  ++k+v++ + +++ ++++  +   ++++k++ +n++ lk
  EFC39010.1  27 LFSTEECSKLLKESEEIGYGEAPISTGPTSstMMKDVRN-NSRAMIDKKQYSDMlYKKLEKYLPQNVSSLK 96 
                 6799***********************987543333333.3333444443333313445777777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       421  (0.0234815); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 1237.10
//
Query:       EFC39011.1  [L=549]
Description: hypothetical protein NAEGRDRAFT_52719 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.6e-09   35.9  47.7     0.0019   18.5   5.2    9.5  8  LRR_4          Leucine Rich repeats (2 copies)
     0.0011   18.7  25.5      0.036   13.8   0.3    6.5  5  LRR_8          Leucine rich repeat
  ------ inclusion threshold ------
      0.058   13.4   0.3        0.3   11.1   0.0    2.3  2  Phage_spike_2  Phage spike trimer
       0.16   12.3   1.8        1.9    8.7   0.4    2.8  3  DUF4332        Domain of unknown function (DUF4332)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.3      0.14   6.3e+02      10      31 ..      62      83 ..      58      97 .. 0.61
   2 !   14.6   2.6   7.5e-06     0.034       1      43 [.     161     207 ..     161     208 .. 0.83
   3 !   18.5   5.2   4.3e-07    0.0019       2      36 ..     187     222 ..     186     235 .. 0.82
   4 !    4.9   3.0    0.0083        37       1      33 [.     212     250 ..     212     287 .. 0.80
   5 !    9.8   1.9   0.00025       1.1       2      33 ..     296     328 ..     295     359 .. 0.88
   6 !   14.1   0.8   1.1e-05     0.049       2      33 ..     387     419 ..     386     430 .. 0.90
   7 !    6.2   0.4    0.0032        15      16      32 ..     438     453 ..     423     462 .. 0.67
   8 !    5.9   0.7     0.004        18       2      28 ..     472     502 ..     471     514 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.14
                SS.---E-S-HHH-TT..--EEE-. CS
       LRR_4 10 nN.qltdiplleklpn..LkeLdLs 31
                nN ++     + ++ n  LkeLd++
  EFC39011.1 62 NNcMID---EFVGNINefLKELDVH 83
                441344...555444445****984 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 7.5e-06
                 SS--EEE--SS---E-S-HH...H-TT--EEE-..-S-----GGGGX CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpnLkeLdL.sgNnlitdldeLk 43 
                 +n ++L+L++  + +++ l+   kl nL++L+L s+N  i+++ +Lk
  EFC39011.1 161 KNVTSLSLFSAGVDTFQVLSnckKLENLTKLNLaSNNMGIQSVKNLK 207
                 689999***999999999776757999******88888888888876 PP

  == domain 3  score: 18.5 bits;  conditional E-value: 4.3e-07
                 S--EEE--.SS.---E-S-HH..H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLs.nN.qltdiplle..klpnLkeLdLsgNnli 36 
                 nL++L+L+ nN  ++++ +l+  +++nL++L+L  N  +
  EFC39011.1 187 NLTKLNLAsNNmGIQSVKNLKkcSMKNLTKLNL-AN--V 222
                 9*******6664499988888878*********.65..4 PP

  == domain 4  score: 4.9 bits;  conditional E-value: 0.0083
                 SS--EEE--SS---E-S-......HH.H.-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl......le.k.lpnLkeLdLsgN 33 
                 +nL++L+L+n  ++++        l+ + + + k+LdL++ 
  EFC39011.1 212 KNLTKLNLAN--VKKFTEkeakelLNsSfMSSVKKLDLTSH 250
                 69*******9..88877765566544877999999999443 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.00025
                 S--EEE--SS---E-S-HH.H-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdiplle.klpnLkeLdLsgN 33 
                 nLe+L ++n +lt  p+++ +l+n + LdLs +
  EFC39011.1 296 NLEYLGIRNHRLTLYPNFWtSLTNITRLDLSYC 328
                 99******559**99999955*********988 PP

  == domain 6  score: 14.1 bits;  conditional E-value: 1.1e-05
                 S--EEE--SS---E-S-HHH.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipllek.lpnLkeLdLsgN 33 
                 +L+ L+L ++ ++++p+l+  +pnLk L++s+ 
  EFC39011.1 387 SLTDLNLKSTYISTFPSLSYhCPNLKRLTISHS 419
                 79***************9966*********874 PP

  == domain 7  score: 6.2 bits;  conditional E-value: 0.0032
                 -S-HHH-TT--EEE-.- CS
       LRR_4  16 iplleklpnLkeLdLsg 32 
                 ++ +  l nL++Ld+s+
  EFC39011.1 438 LSAPT-LSNLEYLDISD 453
                 33455.********965 PP

  == domain 8  score: 5.9 bits;  conditional E-value: 0.004
                 S--EEE--SS---E-S-HH....H-TT--EE CS
       LRR_4   2 nLevLdLsnNqltdiplle....klpnLkeL 28 
                 nL++L ++ +++  i+l e    k++nL  L
  EFC39011.1 472 NLKELICQCCNMDGINLYEnlvsKCTNLVNL 502
                 9****************44455647776555 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.9   5.0    0.0049        22       2      34 ..     187     221 ..     186     251 .. 0.87
   2 ?   -1.4   2.2      0.44     2e+03      25      31 ..     240     246 ..     212     276 .. 0.51
   3 !    6.9   0.3    0.0012       5.2      26      59 ..     296     328 ..     289     330 .. 0.78
   4 !   13.8   0.3   8.1e-06     0.036      24      58 ..     385     418 ..     382     420 .. 0.93
   5 ?    2.3   0.1     0.033   1.5e+02      23      34 ..     442     453 ..     428     476 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0049
                 T-SEEE-TTS-..-SEE-TTSSTT-TT--EEE--S CS
       LRR_8   2 nLtsLdLsnNr..ltslddeaFkglsnLkvLdLsn 34 
                 nLt+L+L +N+  ++s++     +++nL+ L+L n
  EFC39011.1 187 NLTKLNLASNNmgIQSVKNLKKCSMKNLTKLNLAN 221
                 89999999999999999999999999999999987 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.44
                 TT--EEE CS
       LRR_8  25 snLkvLd 31 
                 s++k Ld
  EFC39011.1 240 SSVKKLD 246
                 3333333 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0012
                 T--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8  26 nLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 nL++L ++n +lt   p+ + +L++++ LdLs++
  EFC39011.1 296 NLEYLGIRNHRLTLY-PNFWTSLTNITRLDLSYC 328
                 788888888888877.788888888888888876 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 8.1e-06
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                  s+L+ L+L++  ++t+ p    ++p+L+ L++s+
  EFC39011.1 385 QSSLTDLNLKSTYISTF-PSLSYHCPNLKRLTISH 418
                 589**************.9**************99 PP

  == domain 5  score: 2.3 bits;  conditional E-value: 0.033
                 T-TT--EEE--S CS
       LRR_8  23 glsnLkvLdLsn 34 
                 +lsnL++Ld+s+
  EFC39011.1 442 TLSNLEYLDISD 453
                 488888888885 PP

>> Phage_spike_2  Phage spike trimer
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.2      0.68   3.1e+03      50      70 ..     203     223 ..     183     226 .. 0.59
   2 ?   11.1   0.0   6.7e-05       0.3      29      57 ..     344     372 ..     329     376 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.68
                    STTTT--BT-EEEE--SSEEE CS
  Phage_spike_2  50 dkhavtRaalnLfelrvssvt 70 
                     k+  + +  nL +l+ + v 
     EFC39011.1 203 VKNLKKCSMKNLTKLNLANVK 223
                    344455556778888777765 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 6.7e-05
                    -TTS---EEESEEE-TTSEE-STTTT--B CS
  Phage_spike_2  29 apdtatvkveklvWdksniiGdkhavtRa 57 
                    +p+ +t k e+++W ++ni G+  a  R+
     EFC39011.1 344 LPKLTTLKAENFNWGNANIFGGPTAHYRQ 372
                    6788999***************9998885 PP

>> DUF4332  Domain of unknown function (DUF4332)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.12   5.4e+02      61      84 ..     160     183 ..     149     191 .. 0.70
   2 ?    8.7   0.4   0.00043       1.9      12      59 ..     196     243 ..     186     251 .. 0.86
   3 ?   -1.7   0.0      0.74   3.3e+03      14      59 ..     484     530 ..     477     536 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.12
     DUF4332  61 igeeyaeLLeaaGvdsvaeLaqrn 84 
                 i+   +  L  aGvd+ + L++++
  EFC39011.1 160 IKNVTSLSLFSAGVDTFQVLSNCK 183
                 555566667888888888888754 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00043
     DUF4332  12 kkaGikttedLlelgktekgrkalaeklgisernvlklanlAdLarik 59 
                 ++ Gi+++++L +++ ++ ++ +la+  +++e++ ++l n   ++ +k
  EFC39011.1 196 NNMGIQSVKNLKKCSMKNLTKLNLANVKKFTEKEAKELLNSSFMSSVK 243
                 688*******************************99998876665555 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.74
     DUF4332  14 aGikttedLlelgkt.ekgrkalaeklgisernvlklanlAdLarik 59 
                  Gi+  e+L++++ +  + rk  a++  +s   v++l+   ++a+  
  EFC39011.1 484 DGINLYENLVSKCTNlVNLRKIDAHSVSASKACVKALQTNPTFAKLR 530
                 67777888776554415567788888888888888888777666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (549 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 3116.55
//
Query:       EFC39012.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   15.0   0.2         34    4.7   0.1    3.7  3  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.01   1.8e+02       3      22 ..     166     184 ..     164     185 .. 0.82
   2 ?    4.7   0.1    0.0019        34      12      27 ..     262     277 ..     261     278 .. 0.87
   3 ?    3.3   0.0    0.0053        95      12      21 ..     304     313 ..     301     320 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.01
                 SEEEEEEETTTEEEEEECCC CS
         NHL   3 yPhGvavdsnGdiyVaDsen 22 
                 + +G+ v+ + ++yV D+e 
  EFC39012.1 166 NIWGLDVM-GSQLYVVDYEK 184
                 56899998.889*****985 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0019
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 ++ iyV+D++  r++v
  EFC39012.1 262 SDLIYVSDNGGYRLVV 277
                 578*******999987 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.0053
                 TTEEEEEECC CS
         NHL  12 nGdiyVaDse 21 
                 +G +yV+Ds+
  EFC39012.1 304 SGLLYVCDSG 313
                 599*****97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       553  (0.0308439); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 1878.51
//
Query:       EFC39013.1  [L=389]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.6e-09   35.9   0.0    4.6e-08   33.2   0.0    2.0  1  Abhydrolase_3   alpha/beta hydrolase fold
    1.1e-07   31.0   1.1    1.6e-07   30.6   1.1    1.1  1  Say1_Mug180     Steryl acetyl hydrolase
     0.0078   15.5   0.1      0.013   14.8   0.1    1.3  1  Plavaka         Plavaka transposase
  ------ inclusion threshold ------
      0.024   14.2   0.0      0.077   12.5   0.0    1.8  1  LIDHydrolase    Lipid-droplet associated hydrolase
      0.026   14.3   0.0      0.085   12.6   0.0    1.9  2  Abhydrolase_2   Phospholipase/Carboxylesterase
       0.06   12.2   0.0        0.1   11.5   0.0    1.3  1  Phage_min_cap2  Phage minor capsid protein 2
       0.14   11.6   0.0       0.29   10.6   0.0    1.5  1  Peptidase_S9    Prolyl oligopeptidase family


Domain annotation for each model (and alignments):
>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.2   0.0   1.8e-11   4.6e-08       1     153 [.     125     295 ..     125     316 .. 0.71

  Alignments for each domain:
  == domain 1  score: 33.2 bits;  conditional E-value: 1.8e-11
                    EEEE--STTTS--T...TTT.....HHHHHHHHHHHTSEEEEEE---TTTS-TTHHHHHHHHHHHHHHHTH...........HHHTETTCEEEEEE CS
  Abhydrolase_3   1 lvyfHGGGfvlgsl...dth.....dalcrelakelgavvvsvdYrlAPehpfPaavedalaalrwlaeqa...........welgadpsrivlaG 77 
                    +++ HGGGf++g++   d +      + +++ +k     ++s++Yrl  e p+    +d    ++ l +q            +e+g+ ++ i+l G
     EFC39013.1 125 MLFAHGGGFISGNPlglDAQsimygIEQVNKTSKVKCSHILSIEYRLV-EDPAHHENMDRRMLTHSLTDQLedckecfkyliEEKGIPAQDIILTG 219
                    699*******9988433222444444445555555556789******6.777777777777777777777777888888886689*********** PP

                    ETHHHHHHHHHHHHHHHTT---...EEEEEEESE-SST..SSTTSHHHHHCHHTTTSSSSCHHHHHHHHHHHSSGGGGGST CS
  Abhydrolase_3  78 dSaGGnlaaavalrardegepk...vagqvliyPvtdl..ertesesikkaeeladgplltraaldlfwrlylpeadrddp 153
                     SaG+   + +a ++ + g +k   v  ++l++P  d+  +  ++e++    ++++  +ltr++++l ++ +++e+drd+ 
     EFC39013.1 220 FSAGACHLTMMAFQLMNYGDLKvwpVHSIALFSPPCDTsaKIVTKEEW----KEENVIVLTRDMMEL-IDRCISESDRDNF 295
                    *****877777766666665556669********77664333444444....445668899999996.5666668888875 PP

>> Say1_Mug180  Steryl acetyl hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   1.1   6.2e-11   1.6e-07     115     352 ..     115     367 ..      77     372 .. 0.75

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 6.2e-11
  Say1_Mug180 115 etfdPkvDpvllylHGGgfa....lklipvtlv.fLsnlrklfp.dm.ailvsDYtvtaakdq.........skkYplqvleslavydylvkskgf.. 194
                  ++   k  +v+l+ HGGgf+    l+l+  +++ ++++++k+ + +   il  +Y +++   +         ++    q+ ++   ++yl++ kg+  
   EFC39013.1 115 MKNCEKRGKVMLFAHGGGFIsgnpLGLDAQSIMyGIEQVNKTSKvKCsHILSIEYRLVEDPAHhenmdrrmlTHSLTDQLEDCKECFKYLIEEKGIpa 212
                  343346779**********76666899876655166666666554446799999999875544111111111334566888999*********99655 PP

  Say1_Mug180 195 knvvvlGdSaGGnlvLslllklskln.kvvlPkkaiai.SPWlnltildekekeylkasdklDvlclkglelfgklyvnnrepeeelktdefvniekn 290
                  +++++ G SaG   +  + ++l +++  +v+P + ia+ SP +++   + + ke  k ++++ vl+ + +el+++   +  + ++    +++  +e  
   EFC39013.1 213 QDIILTGFSAGACHLTMMAFQLMNYGdLKVWPVHSIALfSPPCDTS-AKIVTKEEWK-EENVIVLTRDMMELIDRCISES-DRDNFSILSNMQQLES- 306
                  89**********99999999988875257***9888744*****99.7888899999.99************99987776.7666667778888888. PP

  Say1_Mug180 291 fdievWseilekckllityGddEilkdqikllidkiselkeksysepknvlidk.qGiHigPi 352
                   d e++s+   k+k +i y ++E +   ++ +++ +   k  + ++ k v+i +    H  P+
   EFC39013.1 307 QDSEMYSKFF-KSKWIINYSKHEEMAPGMEYFVKLLN-SKVSNVNKDKLVVITEdYQFHCYPV 367
                  9*******87.6899******9999888888886665.5555566666666655356777776 PP

>> Plavaka  Plavaka transposase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.1   4.9e-06     0.013      35     110 ..     263     337 ..     245     371 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.9e-06
     Plavaka  35 eepkwmkeeyelwfrdplevikellgnpdfadeldyaPereytdekkgervysemmtgdwaweqqieek.ptegatl 110
                 ++++w++e++ +++rd++e+i   +++ d ++   ++  ++++  ++++ +ys +   +w+ + + +e+ ++    +
  EFC39013.1 263 TKEEWKEENVIVLTRDMMELIDRCISESDRDNFSILSNMQQLE--SQDSEMYSKFFKSKWIINYSKHEEmAPGMEYF 337
                 5678*************************99999999999999..4669************9999333313444444 PP

>> LIDHydrolase  Lipid-droplet associated hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0     3e-05     0.077      31      96 ..     160     224 ..     132     253 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3e-05
  LIDHydrolase  31 pelevlgishaGfeleeeekeakenekvfsLedQiehkedflkellekaksekdvklilvGHSvGa 96 
                   +  ++l i ++  e+  ++++ +++  + sL dQ+e  ++ +k+l+e +k    +++il G S Ga
    EFC39013.1 160 KCSHILSIEYRLVEDPAHHENMDRRMLTHSLTDQLEDCKECFKYLIE-EKGIPAQDIILTGFSAGA 224
                   456889999999999999999*************************9.8899*************8 PP

>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   3.3e-05     0.085      94     117 ..     201     225 ..     178     261 .. 0.76
   2 ?   -2.3   0.0       1.2   3.2e+03     172     215 ..     343     385 ..     339     387 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.3e-05
                    HHHHH.HTT--GGGEEEEEETHHHH CS
  Abhydrolase_2  94 idael.kkgipssriiigGFSqGaa 117
                     ++ + +kgip+++ii+ GFS Ga 
     EFC39013.1 201 FKYLIeEKGIPAQDIILTGFSAGAC 225
                    444441468**************84 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.2
                    HHHHHHHHHHHHTTS-GEEEEEETT--SS--HHHHHHHHHHHHH CS
  Abhydrolase_2 172 lalgkaakevlkkllkkvelksyeglaHsideeemqdikeflkk 215
                    + +++  k  l  + +++++++y+ + H   +e+ + + + l+ 
     EFC39013.1 343 SKVSNVNKDKLVVITEDYQFHCYP-VVHCLIPESRRTMISVLQQ 385
                    555566667777778899999999.9998888887777776665 PP

>> Phage_min_cap2  Phage minor capsid protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   3.9e-05       0.1      47     133 ..     267     351 ..     255     383 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 3.9e-05
  Phage_min_cap2  47 eklaelgllnreilkliskltgksekelrkllkeagdkaiksddkelaiykeaglepkplekseelqqlveaylkqtegelkNltnt 133
                     +k +++ +l+r++++li++   +s++++ ++l+++ + + ++ +  ++ +  + +  + ++k+ee+   +e+++k  +++++N+++ 
      EFC39013.1 267 WKEENVIVLTRDMMELIDRCISESDRDNFSILSNMQQLESQDSE--MYSKFFKSKWIINYSKHEEMAPGMEYFVKLLNSKVSNVNKD 351
                     5566777899*************************998888888..4444333433599************************9875 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00011      0.29      43      82 ..     192     231 ..     178     238 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00011
                   HHHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHHHHHHH CS
  Peptidase_S9  43 nefdDfiaaaealakegyvdserlaitGgSyGGyltgaal 82 
                    +++D+ ++ ++l++e+ + ++ +++tG S+G     +++
    EFC39013.1 192 DQLEDCKECFKYLIEEKGIPAQDIILTGFSAGACHLTMMA 231
                   6789****************************98666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       842  (0.046963); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2245.60
//
Query:       EFC39014.1  [L=1261]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-93  312.9   0.1    1.3e-93  312.9   0.1    2.5  2  XRN_N       XRN 5'-3' exonuclease N-terminus
    1.7e-31  109.7   0.1    1.7e-31  109.7   0.1    2.8  3  XRN_M       Xrn1 helical domain
    1.1e-20   74.2   0.0    1.1e-20   74.2   0.0    2.9  3  XRN1_D1     Exoribonuclease Xrn1 D1 domain
    1.1e-13   51.0   0.4    2.1e-13   50.1   0.4    1.5  1  SH3_12      Xrn1 SH3-like domain
    6.2e-09   36.0   0.0      3e-08   33.7   0.0    2.3  1  XRN1_D2_D3  Exoribonuclease Xrn1 D2/D3 domain


Domain annotation for each model (and alignments):
>> XRN_N  XRN 5'-3' exonuclease N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  312.9   0.1   3.6e-97   1.3e-93       1     241 [.       1     226 [.       1     227 [. 0.93
   2 ?   -4.3   5.7       2.8     1e+04     106     168 ..    1177    1240 ..    1168    1257 .. 0.59

  Alignments for each domain:
  == domain 1  score: 312.9 bits;  conditional E-value: 3.6e-97
                 XXX-HHHHHHHHHSGGGEEE------SSSS-EEEEEEETHHHHHHHHS-SSS-......--SSHHHHHHHHHHHHHHHHHHH-EEEEEEEE------HH CS
       XRN_N   1 mGvpklfrwlserypkivkevieeeeeeekefdnLYlDmNgiihkcshkedkeekelskkpkteeeifkkifkyidrlvkivrprkllylavDGvaPra 99 
                 mGvp+lf+wlseryp i ++++ e++  + ++dnLYlDmNgiih+c+hk     ++  k++ te+e++ kif+yid+l+++++p+k ++la+DGvaPra
  EFC39014.1   1 MGVPRLFKWLSERYPCIASSLT-EAT-IP-TVDNLYLDMNGIIHNCTHK-----DDELKAQLTEKEMILKIFRYIDQLFQLIKPSKHFFLALDGVAPRA 91 
                 9**************7777776.333.33.9****************99.....34568899************************************* PP

                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-BB--------GGGSSTTSHHHHHHHHHHHHHHHHHHHH-GGGGG-EEEEE-TTS-S-HHHHHHH CS
       XRN_N 100 KmnqqRsRRfrsakeakeekeekeelkeelekeekeeeeeeekfdsnvitpGtefmeklsealkafikkklkedpawknlkvilsdaevpGEGEhKime 198
                 KmnqqRsRRfr+  ++++ +++        e++ +++ e+++ fdsn+itpGtefm+kls +lk+fi++k+++d +w+++kvils++evpGEGEhKim+
  EFC39014.1  92 KMNQQRSRRFRKVFDEQQLRKKL-------EQKGEKVPERDNLFDSNCITPGTEFMAKLSMHLKYFIHSKMQTDIKWQQCKVILSGHEVPGEGEHKIMN 183
                 **************999988754.......4456666778899******************************************************** PP

                 HHHHHHTSTTS-TT-EEEEE---THHHHHHHHHT-SSEEEEEE CS
       XRN_N 199 firkqrskpeydpntrhviyglDaDLillsLathepniliLre 241
                 fir  +++++y+pn+rh++yglDaDLi+l+L+thep++++Lre
  EFC39014.1 184 FIRGRKMEAGYQPNERHCLYGLDADLICLGLVTHEPHFMLLRE 226
                 ******************************************9 PP

  == domain 2  score: -4.3 bits;  conditional E-value: 2.8
                  HHHHHHHHHHHHHHH.HHHHHHHHHHHHT-BB--------GGGSSTTSHHHHHHHHHHHHHHHH CS
       XRN_N  106 sRRfrsakeakeeke.ekeelkeelekeekeeeeeeekfdsnvitpGtefmeklsealkafikk 168 
                  +RR +++++++ ++e +++++++e++++e ++++++ +  s+   p+  f ++ +++ ++ ++k
  EFC39014.1 1177 KRRLQQNESQQVQQEgSSQQVQQETKTQEASSSSSTASTSSEDYNPSELFKQSRAKHRQNRVQK 1240
                  4566555555555442366666666666666666666666666666666655555555555554 PP

>> XRN_M  Xrn1 helical domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.7   0.1   4.8e-35   1.7e-31       2     114 ..     279     390 ..     278     443 .. 0.72
   2 ?   -2.4   1.3      0.48   1.7e+03     111     156 ..    1098    1141 ..    1059    1174 .. 0.40
   3 ?   -5.0  12.3       2.9     1e+04      88     175 ..    1174    1260 ..    1157    1261 .] 0.52

  Alignments for each domain:
  == domain 1  score: 109.7 bits;  conditional E-value: 4.8e-35
       XRN_M   2 fdleriiDDfvFlcFFvGNDFLPhlPsLeiregaidlllkvYkkelkklggyltdngevkldrveklvslvgkveekifrkrkeredrkekklakeeea 100
                 +dleriiDDfvF+ FF GNDFLPh+P+L+i+eg+i+ ++ +Yk+ l+k +gylt+ g+v+l+rv+ +v  +++ e+++ ++r + + r+++k+ +++ a
  EFC39014.1 279 YDLERIIDDFVFFIFFTGNDFLPHMPTLDIKEGSINTMIDIYKQILPK-SGYLTELGDVHLERVQDFVRALASQESSMMEQRYTARLRENRKTRRRRGA 376
                 8*********************************************98.69*******************************99998888888888776 PP

       XRN_M 101 skedaaneeaavae 114
                 +++ + +  ++v +
  EFC39014.1 377 KQVVDSEGFKSVGN 390
                 66544333333221 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.48
       XRN_M  111 avaeeklseskvaksaeaeaeaeaeaeaeakaekekrekaekelee 156 
                  ++ ++++++++ +  + a +++++  +++ ++  ++r+ + +++++
  EFC39014.1 1098 YNYDMPKVQNNQK--QPASPQTQQPNNQRPQQPYKQRQFQPNNNNK 1141
                  2221111111111..1111111122222222222222222222222 PP

  == domain 3  score: -5.0 bits;  conditional E-value: 2.9
       XRN_M   88 drkekklakeeeaskedaaneeaavaeeklseskvaksaeaeaeaeaeaeaeakaekekrekaekeleeseeeeeeeDkvrLgeeGyk 175 
                  ++++++l+++e+++ +++ ++++ ++e+k++e++ + s + +++++++ ++  k+ + k++++   ++++++e++ +D + + ++ yk
  EFC39014.1 1174 KHEKRRLQQNESQQVQQEGSSQQVQQETKTQEASSSSSTASTSSEDYNPSELFKQSRAKHRQNRV-QKQTTTEDSAHDYLNMLQTQYK 1260
                  33334444444444444445555555555555555555555555555555555555444444443.4444555566777666666665 PP

>> XRN1_D1  Exoribonuclease Xrn1 D1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.2   0.0   3.1e-24   1.1e-20       2     179 ..     513     691 ..     512     706 .. 0.86
   2 ?   -2.4   0.0      0.97   3.5e+03     111     179 ..     912     976 ..     906     981 .. 0.71
   3 ?   -5.0   3.5         5   1.8e+04      96     128 ..    1188    1220 ..    1174    1244 .. 0.62

  Alignments for each domain:
  == domain 1  score: 74.2 bits;  conditional E-value: 3.1e-24
                 S-TT---GGGS-TTS--STTS-EEEEEE-----SSSS--SS-EEEEEE--.............------HHHHHHHHBTSEEEESGGG-EEEEEEEEE- CS
     XRN1_D1   2 LlegaklgaealaGFPsLktlpftaeLefhgvnvFqqeSrneSmvvtied.............keenlkleelakeklgkrvfvgyPfLrEakvvavsd 87 
                 L++g+k+g++ l GFP L+    + e +  g+ +F+++S+++S+v++++               ee+ k+++  ++++gk+v++gyP+ r + + ++ d
  EFC39014.1 513 LCDGVKIGKHNLEGFPVLDCKTTQVEEKDVGIALFGHPSKKPSLVINMNPqysrdqmmddefvIEESVKAAQGLSKYIGKKVYIGYPYPRLGILSSIAD 611
                 8*******************9999999999*****************98645444544445544566677777789*********************** PP

                 SS-EEEEE-..SSSEEEEEE--THHHHHHHHHHHHHHHHHHHHHH-EEES--S-EEEEEEEEEEEE-TTS-EEEEE-SS-EE...EEGGG-B CS
     XRN1_D1  88 elfkyekelleekkkkvvsrphsekekkefkkkaerierkyskrlgviigevevlvhveplkGLkrteeGalvKeyeeeeeleteyalqlvv 179
                 e  +y         ++   + h+e++++ f+k+ +  +++  +r+g+ ig+v+vl+ v+  kG+kr++ G + K+++++ e    y+  l+v
  EFC39014.1 612 ERASYF--------ENSEPEYHNERDAEMFRKEYSYHKNVLLRRYGLDIGNVKVLLFVKLFKGMKRDKFG-IKKSFHRD-EF--AYPHSLIV 691
                 ******........23456789999*****************************************9999.68999943.33..58877776 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.97
                 HHHHHHHHHHHHHHHHHHHHHH-EEES--S-EEEEEEEEEEEE-TTS-EEEEE-SS-EE...EEGGG-B CS
     XRN1_D1 111 ekekkefkkkaerierkyskrlgviigevevlvhveplkGLkrteeGalvKeyeeeeeleteyalqlvv 179
                 +++ k +++k ++i+++  ++    +  v++   v p++ Lk  ee a+  e+++++ +  + alq +v
  EFC39014.1 912 HEKDKYYQTKVAEITKWIDEQGFRSLPFVDIEQDVLPVSALKAIEEAAI--EFSKQPAQ--TPALQSIV 976
                 4445567777788888887777777888888889999999999988886..67766665..56666655 PP

  == domain 3  score: -5.0 bits;  conditional E-value: 5
                  -..SSSEEEEEE--THHHHHHHHHHHHHHHHHH CS
     XRN1_D1   96 lleekkkkvvsrphsekekkefkkkaerierky 128 
                  +++e++++ v+++++++e+++ +++a++ ++ y
  EFC39014.1 1188 VQQEGSSQQVQQETKTQEASSSSSTASTSSEDY 1220
                  345555555555555566555555555555555 PP

>> SH3_12  Xrn1 SH3-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.1   0.4   5.9e-17   2.1e-13       2      68 .]     997    1062 ..     996    1062 .. 0.94

  Alignments for each domain:
  == domain 1  score: 50.1 bits;  conditional E-value: 5.9e-17
      SH3_12    2 qfrLgdrVvyvrdngksVPlGlrGtVVgrsdtlleVlfDeeflsgtdlggrcskmrgifvpptdlln 68  
                  +f+Lg+rV+ ++ +g+   +Gl Gt Vg + +  +V+fDeef++g+++g r+s+ rg++v+  +l+n
  EFC39014.1  997 DFALGHRVMQMSGSGS-ARFGLVGTLVGIDGDNGQVIFDEEFVGGSTFGSRLSTARGAIVSLRSLVN 1062
                  89***********996.***********7778899***************************99987 PP

>> XRN1_D2_D3  Exoribonuclease Xrn1 D2/D3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.7   0.0   8.5e-12     3e-08       2      81 ..     712     792 ..     711     797 .. 0.90

  Alignments for each domain:
  == domain 1  score: 33.7 bits;  conditional E-value: 8.5e-12
                 HHHHS-TT-EEEE-SCTCTTEEEEEEEESSSEEEEEEEBS-SS---SHHH.HHHHHHHHHS-EE------EEHHHHHHHHH CS
  XRN1_D2_D3   2 ieeEFPegskvffLGeyaYGrpaevtghsekklsvvlaklksekepefgk.krikeaeksnrYlpsfavakklglsplvLs 81 
                 +e+E+P++s+v+ LG+ +Y    +v+g+++k l+v l++  s+++p+ ++ k+++++  +++Y+p + ++k+lgl+ ++L 
  EFC39014.1 712 VEKEYPVNSTVLVLGDQSYASLGKVAGYDKKFLKVSLTTPYSDQTPRPKFpKEAVTEFAAEKYVPLHIASKRLGLTKKALG 792
                 79*************************************9999988877635677788999***************99996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2070  (0.115455); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.05u 0.35s 00:00:01.40 Elapsed: 00:00:00.55
# Mc/sec: 6936.33
//
Query:       EFC39015.1  [L=1170]
Description: FH2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.5e-61  206.3  18.4    7.5e-61  206.3  18.4    2.9  3  FH2            Formin Homology 2 Domain
  ------ inclusion threshold ------
       0.38   11.4   4.3    1.4e+02    3.1   4.2    4.4  1  DUF3800        Protein of unknown function (DUF3800)
       0.53   11.0   3.8        7.5    7.3   0.1    3.8  3  CdiI_2         CdiI immunity protein


Domain annotation for each model (and alignments):
>> FH2  Formin Homology 2 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1      0.27   1.6e+03     282     334 ..     121     169 ..      79     178 .. 0.69
   2 ?   -1.7   4.4       0.2   1.2e+03     277     316 ..     507     548 ..     499     577 .. 0.74
   3 !  206.3  18.4   1.2e-64   7.5e-61       4     352 ..     654    1030 ..     651    1046 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.27
                 HHHHHHHHHHHHHHHHHHHHCCTTSSTT-THHHHHHHHHHHHHHHHHHHHHHH CS
         FH2 282 ekevkklekglkklekelessekkeepsdkflevlkeflkeaeeklkkleeel 334
                 +k ++ +e g++++ +++++s+     + ++l+ ++e+l+ + +++++  +e 
  EFC39015.1 121 QKLISIIENGCEEILQQFKDSNY----DSNILKTISEVLEVCVDRIDEEDSEN 169
                 44556677788888888888877....77888888888888888777766655 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.2
                 -HHHHHHHHHHHHHHHHHHHHHHHHCCT..TSSTT-THHHHH CS
         FH2 277 nleslekevkklekglkklekelessek..keepsdkflevl 316
                 ++e++++++ kle + +kle++ ++ ek  k++++d f + +
  EFC39015.1 507 DIEQMRQYILKLENENAKLETQKTNLEKkvKKQEQDDFNKNI 548
                 789999999999999999999888888878677777776543 PP

  == domain 3  score: 206.3 bits;  conditional E-value: 1.2e-64
                  X---SS-B------EESSGGCTTSCCCCTCCHHHHC....TSHHHHHHHHTBSC--HCCH......HCSCCTTCCESSS-HHHHHHHHHHHHHH.TS CS
         FH2    4 kikpkkkLkplhWdkvkpsqdrstvWdklkeesfek....eldlseleelFsakekkkkkkksekskkskkkkkkvklLdpkrsqniaIlLkkl.kl 95  
                  k kp++ +kp++ +++ ++++++t++ + k  ++++    ++dl+ l ++F++ e  kk +++ek   +k k ++vk+Ld+++s +i+I Lk++ kl
  EFC39015.1  654 KAKPSTATKPIFLERILNTEVKKTIFVEKKLAENTNelikKIDLESLGKTFQKVEISKKPAEKEKPANNKPKIEEVKVLDQNKSYMISIQLKSIkKL 750 
                  6789999*****************9987776666666799**************99999999899999************************99776 PP

                  -HHH........HHHHHHTTTTCCCTHHHHHHHHHHCGGHHHHHHHHCTCTS..........GTTB-HHHHHHHHHTTSTTHHHHHHHHHHHHTHHH CS
         FH2   96 taee........iveaileldeealdlellenLlkmaPtkeelkklkeykge..........vseLseaeqFllelvkiprlekRleallfkstfee 174 
                  + +e        +++ il++de  +d el+ +L+k +Pt+ee++ + ++ +e          v+ L+  e+F++e+ +ip+  +R++a+ fk ++++
  EFC39015.1  751 NKDEtdemkfarLRRGILQMDE-SYDTELVSCLSKCMPTSEEVESVTKTAEElenlpqnpmnVKVLGLVEKFIYEIRDIPFSLNRIAAWMFKFNLAS 846 
                  6554333333338899******.9**********************8788888899999999*********************************** PP

                  HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHSTCSTT.CS-SEE-GGGGGGCCCSB-STTTSBHHHHHHHHHHTTSGGGGGHHHHTTTH CS
         FH2  175 eveelkrslealeaaseeLknskkfkklLeliLalGNymNdgtrr.gqAkGFkLssLlkLsdvKstdnkttLLHylvkiireklpevldfsseLknv 270 
                  +  +++++le +  a+++L+ns++  +lL+l+L + Ny+N g+++ ++ +GFk ssL  L++vKstd+k t++H+l+++++ek+pe+l++ seL+n+
  EFC39015.1  847 TAMNIRNKLEIIIGACDQLQNSPSWLNLLSLVLTISNYLNTGNSKmQNLYGFKVSSLSVLEQVKSTDQKKTMIHVLCQLCQEKFPEILKLDSELSNI 943 
                  *******************************************9999************************************************** PP

                  HHCCTS-HHHHHHHHHHHHHHHHHHHHHHHHCCT.....TSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT--T CS
         FH2  271 kkaakvnleslekevkklekglkklekelessek.....keepsdkflevlkeflkeaeeklkkleeelkeakelvkelveYfgedk 352 
                  +k+a +n+  +++e+++++++++ ++k ++  e+       ++ d+f+e++ ++++ ae+++ k+ ++l++a+  +k++ e fge++
  EFC39015.1  944 PKCAPMNFFLIREEIQQFKDEVDSVRKTFKLMESmkeknLLDETDRFIEIIGPIIEMAETQIVKIDQLLTKAEHSLKSTQELFGEKD 1030
                  *****************************999998877667899***************************************9865 PP

>> DUF3800  Protein of unknown function (DUF3800)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   4.2     0.024   1.4e+02      28      57 ..     955    1076 ..      57    1151 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.024
     DUF3800   28 e.eikkleekikelkkky............................................................................... 44  
                  + ei+++++++++++k +                                                                               
  EFC39015.1  955 ReEIQQFKDEVDSVRKTFklmesmkeknlldetdrfieiigpiiemaetqivkidqlltkaehslkstqelfgekdimkdenpngipstisdetlse 1051
                  3344555555555555558888888877777777777777777777777777775555666656666666666666666666666666666666666 PP

     DUF3800   45 ............krlleriakflkk 57  
                              + l++ +a+f+++
  EFC39015.1 1052 slkphqnmeiekRTLISIVAHFIQN 1076
                  6666666666666666666666655 PP

>> CdiI_2  CdiI immunity protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.1    0.0013       7.5      18      76 ..     125     182 ..     122     188 .. 0.82
   2 ?   -1.9   0.2      0.95   5.7e+03      20      52 ..     961     992 ..     954     994 .. 0.62
   3 ?    2.2   0.0      0.05     3e+02      14      39 ..    1056    1081 ..    1056    1111 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0013
      CdiI_2  18 dlegdsieeiledYvssespeevaelideieellassldeeleeaflaelgaefdpeaw 76 
                 ++++++ eeil+++++s  + ++ ++i+e+ e    + de  +++  +++ ++ ++++w
  EFC39015.1 125 SIIENGCEEILQQFKDSNYDSNILKTISEVLEVCVDRIDE-EDSENSNDMAKDSKYSKW 182
                 578899*************************999999987.566555666666666655 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.95
      CdiI_2  20 egdsieeiledYvssespeevaelideieella 52 
                 ++d+++ + + ++  e  ++ + l+de +++++
  EFC39015.1 961 FKDEVDSVRKTFKLME-SMKEKNLLDETDRFIE 992
                 4455555555555544.5666778888888875 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.05
      CdiI_2   14 hQDydlegdsieeiledYvssespee 39  
                  hQ++++e+ ++  i++ +++ +++  
  EFC39015.1 1056 HQNMEIEKRTLISIVAHFIQNMTKTH 1081
                  9******************9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2263  (0.12622); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.98u 0.32s 00:00:01.30 Elapsed: 00:00:00.54
# Mc/sec: 6502.46
//
Query:       EFC39016.1  [L=1487]
Description: FH2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-60  204.4  17.3    2.9e-60  204.4  17.3    4.1  4  FH2       Formin Homology 2 Domain
    1.5e-09   37.7   2.7    1.5e-09   37.7   2.7    4.0  3  Drf_GBD   Diaphanous GTPase-binding Domain
    5.3e-07   29.4   1.2    5.3e-07   29.4   1.2    4.2  3  Drf_FH3   Diaphanous FH3 Domain


Domain annotation for each model (and alignments):
>> FH2  Formin Homology 2 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   1.2     0.022   1.3e+02      66     129 ..     240     304 ..     201     323 .. 0.75
   2 ?   -4.5  12.9       1.4   8.6e+03     266     346 ..     658     737 ..     595     761 .. 0.81
   3 !  204.4  17.3   4.8e-64   2.9e-60       5     370 ..     921    1315 ..     918    1317 .. 0.92
   4 ?   -4.1   3.7         1   6.2e+03      56      85 ..    1330    1366 ..    1314    1450 .. 0.51

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.022
                 HCSCCTTCCESSS.-HHHHHHHHHHHHHHTS-HHHHHHHHHTTTTCCCTHHHHHHHHHHCGGHHH CS
         FH2  66 kkskkkkkkvklL.dpkrsqniaIlLkklkltaeeiveaileldeealdlellenLlkmaPtkee 129
                 k+ +k++++  l+ ++ + ++ + +Lk+++ ++  i+++++e + + l+l ++ + l+++ t + 
  EFC39016.1 240 KQISKEEEEDNLIkENHLNKQEQLTLKAINASPSLIIKKFTERNFDLLQLKTISEVLTICSTLSA 304
                 334444444444415667888899*************************9999999999887433 PP

  == domain 2  score: -4.5 bits;  conditional E-value: 1.4
                 HTTTHHHCCTS-HHHHHHHHHHHHHHHHHHHHHHHHCCTTSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         FH2 266 eLknvkkaakvnleslekevkklekglkklekelessekkeepsdkflevlkeflkeaeeklkkleeelkeakelvkelve 346
                 eL  + k+++  + +le+e+ +++k+l + ++ele+ +  ee s+k ++ l++f++  +   k+   +l+ +k++ ++l+ 
  EFC39016.1 658 ELDGLVKTQQRTILDLENEIMNMKKELFQQKQELEKRDA-EERSKKRKQTLSSFMNAVTNLSKEETLKLELTKSKEENLTL 737
                 677788888888999********************9999.89999999999999998887666666666666665555554 PP

  == domain 3  score: 204.4 bits;  conditional E-value: 4.8e-64
                  ---SS-B------EESSGGCTTSCCCCTCCHHHHC....TSHHHHHHHHTBSC--HCCH......HCSCCTTCCESSS-HHHHHHHHHHHHHH.... CS
         FH2    5 ikpkkkLkplhWdkvkpsqdrstvWdklkeesfek....eldlseleelFsakekkkkkkksekskkskkkkkkvklLdpkrsqniaIlLkkl.... 93  
                   kp++k+k ++ d + ++  ++t++ k    + ++    ++dl  +ee F++ e+k ++ +    + +kkk +++ l+d krs+ni+I +++l    
  EFC39016.1  921 AKPRRKTKVFFFDTIPQTNIQQTIFIKNGIAEKTNewikKIDLGTIEEAFEKVEEKAIATD----QPAKKKVEEIILIDGKRSNNISIQFSALkkld 1013
                  689********************9988776665556799****************999988....9**********************766554005 PP

                  TS-HHHHH.....HHHHTTTTCCCTHHHHHHHHHHCGGHHHHHHHHCTCTS.............GTTB-HHHHHHHHHTTSTTHHHHHHHHHHHHTH CS
         FH2   94 kltaeeiv.....eaileldeealdlellenLlkmaPtkeelkklkeykge.............vseLseaeqFllelvkiprlekRleallfkstf 172 
                  + ++++++     +ai+e+de+++d + +e L+  +P +ee+  +++y ++             ++ +  ae F+  l++ip   +R++++ fk ++
  EFC39016.1 1014 NSETDQMKcaryrNAIIEMDEKTVDDNNIEVLSGCMPLDEEIPVIQKYLDDtkeeevsedpdapKKVIPMAETFFTFLLDIPSPLTRVQSWDFKLKL 1110
                  555666643333389***************************99987777777788999999988889999************************** PP

                  HHHHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHHHHHSTCSTT...CS-SEE-GGGGGGCCCSB-STTTSBHHHHHHHHHHTTSGGGGGHHHH CS
         FH2  173 eeeveelkrslealeaaseeLknskkfkklLeliLalGNymNdgtrr...gqAkGFkLssLlkLsdvKstdnkttLLHylvkiireklpevldfsse 266 
                   ++++ ++++l++   +++eL+ s k++ +L liL +GNy N+   +   ++ +GFk+ssL+k++++K++d k+++L yl+++++ ++pe+l +s++
  EFC39016.1 1111 GSRISAIRPKLDSMLNGCKELQASTKLHDILALILTIGNYINQHAPNkklQNIYGFKISSLEKMQTMKARDPKQSMLQYLAQVCQDNFPELLTVSND 1207
                  ******************************************97655346899******************************************** PP

                  TTTHHHCCTS-HHHHHHHHHHHHHHHHHHHHHHHHCCT..TSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT--TT..CCHHHH CS
         FH2  267 Lknvkkaakvnleslekevkklekglkklekelessek..keepsdkflevlkeflkeaeeklkkleeelkeakelvkelveYfgedkk..evspee 359 
                  L++v+ +++++l  +++++kkl+++ kk++  +e+ +k  + +p+d+flev++e + +a+ +l+ +e+  ++++e++k ++  f+e+++    +p+ 
  EFC39016.1 1208 LSSVQTCTRLQLAPIDQDIKKLQEDTKKTKNFFEKMKKekNIHPKDRFLEVMEETIGTAQNQLEIIEKSRTTVEENLKLIAALFDEKPQdlLDKPDT 1304
                  ************************************999899***********************************************77779*** PP

                  HHHHHHHHHHH CS
         FH2  360 ffkilreFlke 370 
                  ff ++++F++ 
  EFC39016.1 1305 FFTQIHNFVES 1315
                  ********986 PP

  == domain 4  score: -4.1 bits;  conditional E-value: 1
                  HCCH.............HCSCCTTCCESSS-HHHHHH CS
         FH2   56 kkkkkks.......ekskkskkkkkkvklLdpkrsqn 85  
                  ++k+k++       +k++k+   +kk +lL ++++ +
  EFC39016.1 1330 EEKEKQKklqeetkKKNEKQLGFDKKKELLMQRKKAA 1366
                  2222221222322223333333344444444444444 PP

>> Drf_GBD  Diaphanous GTPase-binding Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.7   2.7   2.5e-13   1.5e-09      56     186 ..     259     412 ..     224     414 .. 0.82
   2 ?   -6.6   7.3         3   1.8e+04      21      83 ..     687     748 ..     662     769 .. 0.48
   3 ?    2.3   6.9     0.017     1e+02      22      89 ..    1338    1404 ..    1324    1407 .. 0.84

  Alignments for each domain:
  == domain 1  score: 37.7 bits;  conditional E-value: 2.5e-13
     Drf_GBD  56 lsksksksneeespesyvkklkddslke...................kqlesLrVaLrtqpls...WvkrFieleGlvaLlnvLskinekkaeeeedlk 132
                 ++++ + +  ++sp+  +kk  + + +                    +  + L+++ +++ ++   W++ F++ +Gl+ L++ L      ++  ee+ +
  EFC39016.1 259 KQEQLTLKAINASPSLIIKKFTERNFDLlqlktisevlticstlsaeEDQSLLEISTTSEEVKysvWLRGFLNEGGLTSLADCLASTALSTSADEEKET 357
                 333356666777888888888888888778888888888888888765556689999999998889********************************* PP

     Drf_GBD 133 keyeiikClKalmNnk.vGldavlahksvikllaqsldserlktrklvlelLtal 186
                 ke+ ++kC+  ++N++ + +   +++k+++ +l+  lds+ l+ r ++l lL+++
  EFC39016.1 358 KEVYCLKCIETILNTSdYARGCFFKNKDILRTLVLTLDSNSLELRSQILLLLSVI 412
                 **************97377889999***************************997 PP

  == domain 2  score: -6.6 bits;  conditional E-value: 3
     Drf_GBD  21 nlpeekreallalpiekKwqlvvqdkkkkakkeeklsksksksneeespesyvkklkddslke 83 
                 + +e +++  ++ + ++K++l    +  ++ ++  ++ + +  +++e    + +klk+ ++++
  EFC39016.1 687 QKQELEKRDAEERSKKRKQTLSSFMNAVTNLSK-EETLKLELTKSKEENLTLTDKLKEAEAEK 748
                 222333344444444455555444333333333.22223333333444455555666555555 PP

  == domain 3  score: 2.3 bits;  conditional E-value: 0.017
     Drf_GBD   22 lpee.kreallalpiekKwqlvvqdkkkkakkeeklsksksksneeespesyvkklkddslkekqlesL 89  
                  l+ee k+++  +l ++kK++l +q kk+ +++    ++  +k + ++ p+s+  +l++ ++k+  l+sL
  EFC39016.1 1338 LQEEtKKKNEKQLGFDKKKELLMQRKKAASSTT--ATSLLTKPSINATPQSPSFDLSSLKSKTSLLSSL 1404
                  55550556667899*************999988..8889999999999999999999999999999998 PP

>> Drf_FH3  Diaphanous FH3 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4   1.2   8.9e-11   5.3e-07       2      78 ..     422     509 ..     421     660 .. 0.91
   2 ?   -7.4   9.1         3   1.8e+04      87     144 ..     672     728 ..     655     777 .. 0.58
   3 ?   -3.0   4.5      0.78   4.7e+03      75     139 ..    1271    1335 ..    1270    1369 .. 0.86

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 8.9e-11
                 HHHHHHHHHHHHHHCCT-SSTTHHHHHHHHH............HSS-HHHHHHHHHHHHHHHHSSSSHHHHHHHHHHHHCTTHHHHHH CS
     Drf_FH3   2 ghekvleatldfkevaeergrfrslvgaldel...........enelveykvatmllInalvnspedlqfRlhLRseflalGLdkiid 78 
                 g e++l+a++ fk  ++e++rf  l+++l++l           + +  +y ++tm+++n l++  ++  +R+ L  e ++lGL+ +++
  EFC39016.1 422 GFELILDALTSFKLIKREPKRFHFLIDSLNFLagenlevddmfNGAIASYVLTTMIFFNSLISVSPNEGVRISLMREWKNLGLHMAVK 509
                 6799**************************99***************************************************97665 PP

  == domain 2  score: -7.4 bits;  conditional E-value: 3
                 HHHHHHHHHHHHHHHHHHHHHHHHTXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXX CS
     Drf_FH3  87 eLddqlqafeeerneDeeelleraedktvdlddpeelfellknkvkdteaepyl.lsil 144
                 +L++++ ++++e ++ ++el +r    +   ++ ++++++++n v++ + e  l l++ 
  EFC39016.1 672 DLENEIMNMKKELFQQKQELEKRDA--EERSKKRKQTLSSFMNAVTNLSKEETLkLELT 728
                 5777777777777777777777766..44445555555555555555555544433322 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 0.78
                  HHHHHHCTSCSHHHHHHHHHHHHHHHHHHHHHHHHHT.XXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
     Drf_FH3   75 kiidklreleneeLddqlqafeeerneDeeellerae.dktvdlddpeelfellknkvkdteaepy 139 
                  +ii+k r++  e+L+    +f+e+ + D  +  + +  + +   ++ ++  e lk+k ++ e e++
  EFC39016.1 1271 EIIEKSRTTVEENLKLIAALFDEKPQ-DLLDKPDTFFtQIHNFVESLNKACEDLKAKREKEEKEKQ 1335
                  7999**********999999999888.766666665558899999999999999999999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1487 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2744  (0.153048); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.28u 0.30s 00:00:01.58 Elapsed: 00:00:00.56
# Mc/sec: 8001.93
//
Query:       EFC39017.1  [L=159]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-37  129.2   4.7    1.4e-37  129.0   4.7    1.0  1  DUF866         Eukaryotic protein of unknown function (DUF866
  ------ inclusion threshold ------
      0.084   12.8   2.4       0.17   11.8   0.2    2.2  2  zinc_ribbon_4  zinc-ribbon domain
       0.21   11.6   5.6       0.82    9.7   5.6    1.9  1  Zn_Tnp_IS1595  Transposase zinc-ribbon domain
       0.49   10.0   4.7         11    5.7   0.4    2.5  2  Sgf11          Sgf11 (transcriptional regulation protein)
        4.2    7.6   6.4         19    5.5   0.3    2.7  3  E7             E7 protein, Early protein


Domain annotation for each model (and alignments):
>> DUF866  Eukaryotic protein of unknown function (DUF866)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  129.0   4.7   3.8e-41   1.4e-37       2     154 ..       6     157 ..       5     158 .. 0.91

  Alignments for each domain:
  == domain 1  score: 129.0 bits;  conditional E-value: 3.8e-41
                 EEEEEEEESEEEEE--T...T--EEEEEEETTSS.-EEEEEEE-TT-BEE-TTSS-EE..SEEE--SSSS--EEEEEE-.-TTTTEEEGGTS-EEEEEE CS
      DUF866   2 LqikaelenvtslepadeeedfeytfkvkctsCreehpkevsisreekveisgsrgea..nfvvkcklckressisikketeksytaedsgkfktilef 98 
                 L++ ++l+++++++++d  + f++ +kvkc +C++eh+k++ i+++ek++ + + g+   n+ + c+ ckr+++i++++++ k++t+++  kf ++++f
  EFC39017.1   6 LEVAMTLQGLEKVTIED-PAAFTWRVKVKCPNCQTEHAKHIFICENEKEDKNVKAGTSatNVNFSCSVCKRHATIDVISGSFKEITQSE--KFFPLVQF 101
                 8999***********96.679**************************9998777775445*******************9999998888..999***** PP

                 EEESEEEEEE---S-..EEEEETTS-EEEEE--TS.-EEEEETTTTEEEEEEEEEEEE CS
      DUF866  99 dcrGlelvefkpegg..wkvesasgtkfedvdLsegeWydYdekageeVsitelevei 154
                 dcrG+++v+++peg+  +++ s +g+kfe v+L++ e++dYde++++e+sit++++++
  EFC39017.1 102 DCRGVDIVKWEPEGSegLVAFS-DGNKFE-VNLENMEYFDYDEESEQEISITNIKMKF 157
                 *************974344444.*****9.****99********************98 PP

>> zinc_ribbon_4  zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   4.7e-05      0.17      24      33 ..      30      39 ..      24      41 .. 0.86
   2 ?    0.0   0.2      0.24   8.4e+02      24      32 ..      66      74 ..      60      76 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.7e-05
  zinc_ribbon_4 24 vkvrCskCgh 33
                   vkv+C++C++
     EFC39017.1 30 VKVKCPNCQT 39
                   7999999997 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.24
  zinc_ribbon_4 24 vkvrCskCg 32
                   v+  Cs C+
     EFC39017.1 66 VNFSCSVCK 74
                   666788886 PP

>> Zn_Tnp_IS1595  Transposase zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   5.6   0.00023      0.82      12      45 ..      25      75 ..      24      76 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00023
  Zn_Tnp_IS1595 12 alrWpngfvCPhCgsr..kayrikt...............rglfqCkeCrk 45
                   a+ W+ ++ CP+C+ +  k+++i                    f C+ C++
     EFC39017.1 25 AFTWRVKVKCPNCQTEhaKHIFICEnekedknvkagtsatNVNFSCSVCKR 75
                   578************988888887788888888888888877888888887 PP

>> Sgf11  Sgf11 (transcriptional regulation protein)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.4    0.0034        12       4      11 ..      31      38 ..      29      40 .. 0.84
   2 ?    5.7   0.4    0.0029        11       2      12 ..      65      75 ..      64      78 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0034
                EEE-TTTS CS
       Sgf11  4 yvtCpnCg 11
                 v+CpnC+
  EFC39017.1 31 KVKCPNCQ 38
                799****6 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.0029
                C-EEE-TTTSS CS
       Sgf11  2 seyvtCpnCgR 12
                ++ ++C  C+R
  EFC39017.1 65 NVNFSCSVCKR 75
                6789******9 PP

>> E7  E7 protein, Early protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.3    0.0053        19      46      62 ..      23      39 ..      13      51 .. 0.79
   2 ?    5.0   0.3    0.0075        27      33      71 ..      49      84 ..      39      97 .. 0.69
   3 ?   -1.2   0.1      0.67   2.4e+03      18      37 ..     130     149 ..     122     157 .. 0.65

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0053
                XXEE.EEEEEEXTTTXX CS
          E7 46 prrpgYavevaCprCeq 62
                p + +++v+v+Cp+C++
  EFC39017.1 23 PAAFTWRVKVKCPNCQT 39
                5666799********96 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0075
                XXXXXXXXXXXXXXXEE.EEEEEEXTTTXXEEEEEEEEX CS
          E7 33 eeeedeptlkdktprrpgYavevaCprCeqklrlvvlat 71
                e+e++   +k+++    + +v+ +C  C+++  + v + 
  EFC39017.1 49 ENEKE---DKNVKAGTSATNVNFSCSVCKRHATIDVISG 84
                33333...333334444457*********9999988774 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.67
                 X--S------XXXXXXXXXX CS
          E7  18 ldllceeelesedeeeeeed 37 
                 ++l   e  + ++e+e+e +
  EFC39017.1 130 VNLENMEYFDYDEESEQEIS 149
                 56666666676777776655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (159 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1034  (0.0576719); expected 358.6 (0.02)
Passed bias filter:                      566  (0.031569); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.48u 0.32s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 982.06
//
Query:       EFC39018.1  [L=279]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.9e-11   43.8   0.1    3.2e-11   43.1   0.1    1.3  1  SBP_bac_3  Bacterial extracellular solute-binding proteins, f


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.1   0.1   1.8e-15   3.2e-11      44     166 ..     132     261 ..     108     267 .. 0.73

  Alignments for each domain:
  == domain 1  score: 43.1 bits;  conditional E-value: 1.8e-15
                 E..-.SGGGHHHHHHTTSSSEEESSEB--HHHHTTEEEES.ESEEEEEEEEEEE.TT..SHGTCCHSSCGCGTTS..EEEEETTSHHHHHHHHHHHCTS CS
                 x..x.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxx.xx..xxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3  44 p..v.swdelipalksgkvDiaiaaititpeReekvdFsq.pyfsagqvllvrk.kd..askissiksladLkgk..kvgvqagstaeellkeelkkga 133
                 +     ++++ +a+++ ++D+ +a+ t+t eR+ kv Fs+  y s++ ++l    ++  +  + ++k++++L+     v++  g+++e+l++++l+   
  EFC39018.1 132 NatDgFFESMKKAVETEECDVSVADSTYTTERRSKVQFSDcGYGSTANGFLRTLlNKenNATFANLKDISQLNSPdiIVAAYFGTYYETLANQTLPL-- 228
                 243236888999****************************878888777765543321134445555555554443357888899999999987663.. PP

                 EEEEESSHHHHHHHHHTTSSSEEEEEHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 134 eivefdtleealqaLkngrvdavvadspvlayl 166
                   + f + +e ++++kn++v +v+ ds +l+ +
  EFC39018.1 229 AKKIFTSFDEQFELIKNNKVHVVISDSEALQSW 261
                 44559***********************99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       717  (0.0399911); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1685.22
//
Query:       EFC39019.1  [L=2843]
Description: ankyrin repeat and BTB domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-09   38.3   1.9    3.7e-09   36.8   0.4    2.6  3  BTB       BTB/POZ domain
    1.9e-07   31.6   0.0    5.2e-07   30.2   0.0    1.7  1  Ank_2     Ankyrin repeats (3 copies)
    0.00012   22.3   0.0     0.0004   20.6   0.0    1.9  1  Ank_5     Ankyrin repeats (many copies)
    0.00028   21.4   0.0    0.00081   19.9   0.0    1.7  1  Ank_4     Ankyrin repeats (many copies)
     0.0016   18.8   0.1     0.0055   17.1   0.1    2.0  1  Ank_3     Ankyrin repeat
     0.0043   17.4   0.1      0.013   16.0   0.1    1.8  1  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       1.9   5.7e+03      27      62 ..     255     290 ..     245     293 .. 0.80
   2 ?   -2.9   0.0       2.5   7.6e+03      63      78 ..     730     745 ..     717     756 .. 0.82
   3 !   36.8   0.4   1.2e-12   3.7e-09       8      98 ..     825     934 ..     819     945 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.9
                 HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHH CS
         BTB  27 kavLaarSpyFkalftskeieessvseielddvepe 62 
                 ka   ++S+ Fk  ++ ++++ +svs+++  d++++
  EFC39019.1 255 KALTQSCSTQFKGCMERNGDTVQSVSMLQSMDCSSQ 290
                 555578999999999999888999999988888876 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 2.5
                 HHHHHHHHHHHSEEEC CS
         BTB  63 afealLefiYtgelei 78 
                  f++lL +iYtg +  
  EFC39019.1 730 QFDNLLVWIYTGCIVR 745
                 5999*******96654 PP

  == domain 3  score: 36.8 bits;  conditional E-value: 1.2e-12
                 TTTS-EEEEETT..........TEEEEE-HHHHHHH-HHHHHHHTST.....TTTTCCCE....EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHH CS
         BTB   8 gelcDvtlvvgd..........gkefkahkavLaarSpyFkalftsk.....eieessvs....eielddvepeafealLefiYtgeleitseenleel 87 
                  +lc+v++++++          ++++ +hk +L+ rS +F+ l++s+     +++es       ++e++ ++++++++l +fiYtg++e  +e+nl el
  EFC39019.1 825 RSLCNVQIKIENyleevffvesTESILCHKDFLSERSMFFNILLNSNfdeteRMKESALHdeipTLEIQGCNFSVIQELCNFIYTGKFEKLDENNLLEL 923
                 46899999999999999999889************************98777334433336788*************************9999****** PP

                 HHHHHHHT-HH CS
         BTB  88 Laaadllqipr 98 
                 ++  ++l +p+
  EFC39019.1 924 FSYGHRLGFPE 934
                 ****9999886 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.2   0.0   1.7e-10   5.2e-07       4      78 ..     428     507 ..     416     513 .. 0.77

  Alignments for each domain:
  == domain 1  score: 30.2 bits;  conditional E-value: 1.7e-10
       Ank_2   4 AakngnlelvklLlegadpn.k...ngktaLhyAakngnleivklLle....h.adndgrtpLhyAarsghleivklLlekgad 78 
                 A k+g   ++k ++ g ++n +   n k+ ++ ++k g+l+ v++ ++    h  d++g+tpL+yA+ +ghl++vk+L e ga 
  EFC39019.1 428 ALKSG---VIKEMI-GLRINnQifeNRKSDIYSFCKVGDLNRVRATIKisdlHkPDRYGNTPLYYACLCGHLNLVKYLSELGAR 507
                 33445...666666.4555653566999*******************965554888***********************98873 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   1.4e-07    0.0004       8      44 ..     474     506 ..     473     513 .. 0.84

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.4e-07
       Ank_5   8 dvnrldgggntpLhvAakygaadvvrlLlargadlnl 44 
                 d+  +d++gntpL +A+ +g++++v++L +    l++
  EFC39019.1 474 DLHKPDRYGNTPLYYACLCGHLNLVKYLSE----LGA 506
                 66789***********************94....333 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   2.7e-07   0.00081      26      54 ..     474     501 ..     462     501 .. 0.90

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 2.7e-07
       Ank_4  26 dinaqdnrsGetalhiAakrgnveilklL 54 
                 d+++  +r+G+t+l++A++ g+++ +k+L
  EFC39019.1 474 DLHKP-DRYGNTPLYYACLCGHLNLVKYL 501
                 56666.**********************9 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.1   1.8e-06    0.0055       1      27 [.     481     506 ..     481     507 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 1.8e-06
       Ank_3   1 nGetpLhlAarsgnleivkfLlenkga 27 
                 +G+tpL++A+++g+l++vk+L e  ga
  EFC39019.1 481 YGNTPLYYACLCGHLNLVKYLSE-LGA 506
                 79*******************99.775 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.1   4.2e-06     0.013       1      25 [.     481     506 ..     481     513 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 4.2e-06
                 TSBBHHHHHHHHTTHHHHHHH..HTTT CS
         Ank   1 dGnTPLHlAatngkkriiklL..LhGA 25 
                 +GnTPL +A+ +g+++ +k+L  L GA
  EFC39019.1 481 YGNTPLYYACLCGHLNLVKYLseL-GA 506
                 7*******************9555.54 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2843 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1022  (0.0570026); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.24u 0.30s 00:00:01.54 Elapsed: 00:00:00.51
# Mc/sec: 16814.25
//
Query:       EFC39020.1  [L=298]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      9e-62  208.7   0.0    1.2e-61  208.3   0.0    1.0  1  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
    6.2e-50  169.4   0.0    7.9e-50  169.0   0.0    1.1  1  adh_short        short chain dehydrogenase
    7.6e-10   39.0   0.0    1.1e-09   38.5   0.0    1.1  1  KR               KR domain
     0.0022   17.2   0.0      0.003   16.7   0.0    1.1  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
  ------ inclusion threshold ------
      0.013   15.0   0.0      0.018   14.5   0.0    1.3  1  Epimerase        NAD dependent epimerase/dehydratase family
      0.048   12.1   0.1      0.063   11.7   0.1    1.1  1  Hydantoinase_B   Hydantoinase B/oxoprolinase
      0.082   12.3   0.1       0.11   11.9   0.1    1.1  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
       0.16   11.3   0.0       0.28   10.5   0.0    1.3  1  DUF1776          Fungal family of unknown function (DUF1776)


Domain annotation for each model (and alignments):
>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  208.3   0.0   5.2e-65   1.2e-61       4     232 ..      63     294 ..      58     295 .. 0.95

  Alignments for each domain:
  == domain 1  score: 208.3 bits;  conditional E-value: 5.2e-65
                   TSHHHHHHHHHHHTT-EEEEEESSGGH..HHHHHHHHHHTTSE.E.EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH-HHHHH CS
  adh_short_C2   4 sgIGraiAkalaeeGaevvltdlneea..kkrveelaeelgae.v.lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpfletsreefd 96 
                   sgIGr +  ++a+eGa+v++++l+ee+  ++++++l e+ g++ + ++ DV+  + ++++ve++v++f klDilvnna+  +  +++++++s+e+++
    EFC39020.1  63 SGIGRSVSILFAREGANVAIVYLKEEEkdAQETKQLIEKEGRKcLlIPGDVRTSDFCNQAVEKTVKEFSKLDILVNNAATQTV-QQDLTDISDEQLE 158
                   8************************998889999****99999637**********************************998.************* PP

                   HHHHHHTHHHHHHHHHHHHHCTSC.CEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTGGGGSTTHHHHHHHH CS
  adh_short_C2  97 raldvnlyslfllakaalplmkeg.gsivnlssvgaervvpnynaygaaKaalealtrylAvelgpkgiRvNavspgpikTlaasgikgfdelleel 192
                   +++++n+ s+f++a+aal+++ ++ g+i+n++sv + r+ +    y+ +K+a+  +tr+lA +l+++gi vN+v+pgpi T++  +    ++ ++e+
    EFC39020.1 159 NTFKTNIFSYFYMARAALKYLPDQtGRIINTTSVTSYRGKDVLLDYSSTKGAITTFTRSLASNLASRGILVNSVAPGPIWTPLIPSTF-PEDKMKEF 254
                   *******************999888**********************************************************66654.46778999 PP

                   HHHSTTSS-B-HHHHHHHHHHHCSGGGTT--SEEEEESTT CS
  adh_short_C2 193 earaplgrlgtpeevaeaalfLasdeasyitGqtlvvDgG 232
                    +++plgr+g+p e+a a+++Las+++sy+tGqt++v+gG
    EFC39020.1 255 GKSTPLGRAGQPFECATAYVYLASKDSSYVTGQTIHVNGG 294
                   9**************************************9 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  169.0   0.0   3.5e-53   7.9e-50       1     188 [.      54     243 ..      54     250 .. 0.94

  Alignments for each domain:
  == domain 1  score: 169.0 bits;  conditional E-value: 3.5e-53
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEE..EESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---S.S--SSGGGC CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvv..vdrseekleevakelkeegakalaiqvDvtdreevealvekavkklgkldvLvnNAGi.tgsgpfsel 96 
                 kv+l+tG++sGIGr ++  +a+eGa+v++  ++++e++++e+++ +++eg+k l i++Dv++++ ++++vek vk++ kld+LvnNA+  t +++  ++
  EFC39020.1  54 KVALITGGDSGIGRSVSILFAREGANVAIvyLKEEEKDAQETKQLIEKEGRKCLLIPGDVRTSDFCNQAVEKTVKEFSKLDILVNNAATqTVQQDLTDI 152
                 89*************************9975677777888899999999***************************************98889999*** PP

                 SHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHHHH CS
   adh_short  97 seeewervievNltgvflltravlpamlkqssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakelaptgirvnavaPGlvdTdmak 188
                 s+e+ e+++++N++++f ++ra+l+++   + GrI+n++Sv++  +  ++  Ys++K+a++ +trsla  la++gi vn+vaPG++ T++  
  EFC39020.1 153 SDEQLENTFKTNIFSYFYMARAALKYLP-DQTGRIINTTSVTSYRGKDVLLDYSSTKGAITTFTRSLASNLASRGILVNSVAPGPIWTPLIP 243
                 **************************66.999*******************************************************99865 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.5   0.0   4.9e-13   1.1e-09       3     165 ..      56     220 ..      55     238 .. 0.85

  Alignments for each domain:
  == domain 1  score: 38.5 bits;  conditional E-value: 4.9e-13
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE.---------TTT- CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvih.aAgvlrdklleem 100
                  litGG  g+G++++   a++ga+  ++  ++  +++d++++ + +e+ g ++ +++ Dv  +d  ++++e+  +e++++   ++ aA  + ++ l++ 
  EFC39020.1  56 ALITGGDSGIGRSVSILFAREGANVAIVYLKE--EEKDAQETKQLIEKEGRKCLLIPGDVRTSDFCNQAVEKTVKEFSKLDILVNnAATQTVQQDLTDI 152
                 59********************8877777777..678888888899999*******************************99887155556699***** PP

                 -HHHHHHHHTTTTHHHHHHHHHTTT...S--SEEEEEEEHHHHH--TT-HHHHHHHHHHHHHHHHHHH CS
          KR 101 taedleqvlapKvkGawnLhelled...esldffvlfSSiagllgsagqanYaaaNaflDalaeyrrs 165
                 ++e+le+ ++  +     + ++  +   ++   ++ ++S+ +  g+    +Y+++   + ++ ++ +s
  EFC39020.1 153 SDEQLENTFKTNIFSYFYMARAALKylpDQTGRIINTTSVTSYRGKDVLLDYSSTKGAITTFTRSLAS 220
                 *******************99998888899999*******************9987766666655444 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   1.3e-06     0.003       2     117 ..      57     177 ..      56     185 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.3e-06
                      EEETTTSHHHHHHHHHHHHHB-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT.......T-SEEEE------H CS
  Polysacc_synt_2   2 lvtGagGsiGselvrqilkkkpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrdkerlekaleel.....kvdvvfhaAAlKhV 90 
                      l+tG+   iG+++   ++++ ++  i++ ++E k  + +k+l e+  +k l      + gdvr ++ +++a+e++     k d++++ AA+  V
       EFC39020.1  57 LITGGDSGIGRSVSILFAREGANVAIVYLKEEEKDAQETKQLIEKEGRKCL-----LIPGDVRTSDFCNQAVEKTvkefsKLDILVNNAATQTV 145
                      8*************9999998888777777777776666666555555445.....45699999887777766532222489**********99 PP

                      .....HHHHHSHHHHHHHHHHHHHHHHHHHHH CS
  Polysacc_synt_2  91 .....PlveenpleaiktNvlgtenvieaaie 117
                            + +e+  +++ktN+++   +++aa++
       EFC39020.1 146 qqdltDISDEQLENTFKTNIFSYFYMARAALK 177
                      44444478999999*********999999987 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.0   8.1e-06     0.018       1      86 [.      56     154 ..      56     210 .. 0.79

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 8.1e-06
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHC.............EEEE--TT-HHHHHHHHHHH.T-SEEEE--S---HHHHHHSHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledl.............elveldltdrsalerlfkee.qpdavihlAavggvaassedpa 85 
                 +l+tG+   iG+ +   ++++g +v  +  +++++  ++ ++l             ++ + d++++ a+e+ +ke+ + d+ ++ Aa ++v++  +d +
  EFC39020.1  56 ALITGGDSGIGRSVSILFAREGANVAIVYLKEEEKDAQETKQLiekegrkcllipgDVRTSDFCNQ-AVEKTVKEFsKLDILVNNAATQTVQQDLTDIS 153
                 59********************998888888777777777766899*****666666666666654.6999999999**********999999888766 PP

                 H CS
   Epimerase  86 d 86 
                 d
  EFC39020.1 154 D 154
                 5 PP

>> Hydantoinase_B  Hydantoinase B/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   2.8e-05     0.063     140     274 ..      74     219 ..      58     233 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.8e-05
  Hydantoinase_B 140 feEGlrippvklveegeleedvlelllanvRtpednlgDlkAqiaanqvgerrlkelieeyGldtveaamdeildnaeravraalaelpd..... 229
                       EG+ +  v l ee+++ ++  +l++++ R+   + gD+++   +nq  e+ +ke+  + ++ + +aa + ++++      ++l++  +     
      EFC39020.1  74 AREGANVAIVYLKEEEKDAQETKQLIEKEGRKCLLIPGDVRTSDFCNQAVEKTVKEF-SKLDILVNNAATQTVQQDLTDISDEQLENTFKtnifs 167
                     67****************************************************996.5677777788888888888888777776665533333 PP

  Hydantoinase_B 230 gtyeaedyl.........dd.g.ipikvtv.tidgdeatvDftgtspqvkgniNapl 274
                            y+         d+ g i  + +v + +g+++ +D++ t+  + +++ + +
      EFC39020.1 168 Y-----FYMaraalkylpDQtGrIINTTSVtSYRGKDVLLDYSSTKGAITTFTRSLA 219
                     1.....2332333344454444544444552479999*****999988877666555 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   4.8e-05      0.11       1     125 [.      57     187 ..      57     197 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.8e-05
                    EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHH.....T-SEEEE--S---HHH. CS
  GDP_Man_Dehyd   1 LiTGiaGfiGsylaelLlekgyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaev.....qpdevynLAAqshVdv. 90 
                    LiTG+   iG  +  l+ ++g +v ++  ++++ ++++ ++l +++     ++  l+ gD++ s+  +++++++     + d  +n AA   V++ 
     EFC39020.1  57 LITGGDSGIGRSVSILFAREGANVAIVYLKEEEKDAQETKQLIEKE----GRKCLLIPGDVRTSDFCNQAVEKTvkefsKLDILVNNAATQTVQQd 148
                    9*****************************************9754....4679999999998877777776665555789999*****9999872 PP

                    ....HTTSHHHHHHHHTHHHHHHHHHHHHCT..TTSEEE CS
  GDP_Man_Dehyd  91 ....sfekPeytaevnvlGtlrLLeairalglekkvrfy 125
                        s e+ e t+++n+   + +  a+ ++  +++ r++
     EFC39020.1 149 ltdiSDEQLENTFKTNIFSYFYMARAALKYLPDQTGRII 187
                    222244677888888888888888887777555555555 PP

>> DUF1776  Fungal family of unknown function (DUF1776)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00012      0.28     109     195 ..     150     232 ..     143     237 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00012
     DUF1776 109 etiplsswaselnerllspiltlqallplltsrakqkakiivvnpsissslnlpfhapEalvssalsalfevLkrelrphnidvtqi 195
                 + i+ ++++++++++++s++ +  a l+ l      ++  i+ ++s++s          + + +a+++++++L+ +l++ +i v  +
  EFC39020.1 150 TDISDEQLENTFKTNIFSYFYMARAALKYLPD----QTGRIINTTSVTSYRGKDVLLDYSSTKGAITTFTRSLASNLASRGILVNSV 232
                 67999**************************6....445555677777776666666677889999999999999999888877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (298 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       706  (0.0393775); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1799.02
//
Query:       EFC39021.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0083   16.3   0.7       0.94    9.7   0.3    2.3  2  DUF4115    Domain of unknown function (DUF4115)
  ------ inclusion threshold ------
       0.12   12.1  14.5       0.16   11.6  14.5    1.1  1  Laminin_I  Laminin Domain I
       0.35   11.3   1.9       0.54   10.6   1.9    1.3  1  TM2        TM2 domain
        3.2    6.6   7.0        4.2    6.2   7.0    1.2  1  LMBR1      LMBR1-like membrane protein


Domain annotation for each model (and alignments):
>> DUF4115  Domain of unknown function (DUF4115)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   0.3   0.00021      0.94      26      68 ..      51      93 ..      47      98 .. 0.85
   2 !    4.5   0.0    0.0091        41      48      63 ..     113     128 ..     111     132 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00021
     DUF4115 26 lkaGetkevsgkppltltiGnagavevsvnGkpvdllgyargn 68
                ++ G+ +++++++p+++  Gnag  +  vn+ + ++ +y + +
  EFC39021.1 51 FAGGNYVNFNNAQPYQVSNGNAGYSQYYVNDGQQQPQSYVPPQ 93
                678899999999******************9999999985444 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0091
     DUF4115  48 gavevsvnGkpvdllg 63 
                 ++ ++ +nG+pvdl+ 
  EFC39021.1 113 SGFTMYINGQPVDLSN 128
                 68899********986 PP

>> Laminin_I  Laminin Domain I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6  14.5   3.7e-05      0.16      61     147 ..     163     248 ..     149     252 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 3.7e-05
   Laminin_I  61 kkatqvlakaqkvnaesertlnnakeLaekikkladnikeilekvatlneneealpssklseelaeaqrlLeelrsRdftkqleeae 147
                  +a+++++ +  +++  e ++ + +   e+i+++++ni+  +e+  ++nen++ +  +++++++ ++ r+ + + s++++ ++++++
  EFC39021.1 163 RRAEENRRLHDSIRRTNESINRSNEIHRENIRRMNENIHRTNEQNRRTNENNMRMHHQNMNRMHDNM-RMHQNIHSQNMQRMHQQNT 248
                 5788999999999999999999999999************************************997.9***************998 PP

>> TM2  TM2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   1.9   0.00012      0.54      30      50 ..       1      20 [.       1      21 [. 0.93

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00012
         TM2 30 sGvlqlltfvGglgiwwlidl 50
                +G+++l+tf G++g+++++d+
  EFC39021.1  1 MGIVYLFTF-GLCGVGQIFDV 20
                69*******.********996 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   7.0   0.00094       4.2     215     309 ..     163     250 ..     119     259 .. 0.62

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.00094
       LMBR1 215 ekeeaereledllkevkklrksisesdplrkyleeilkkvPeeiaeklksnenkteeslaklekqlikalqkrertekq.wkrllekalelediik 309
                 +++e +r+l    ++++++++si++s+   +   e ++ ++e+i+ ++++n+  +e+++   ++++ ++++++ r +++  +++++++ + ++ ++
  EFC39021.1 163 RRAEENRRLH---DSIRRTNESINRSN---EIHRENIRRMNENIHRTNEQNRRTNENNMRMHHQNM-NRMHDNMRMHQNiHSQNMQRM-HQQNTMN 250
                 3344445555...88888888888888...566666677777888887776666666666666333.333333333333033344443.3333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3073  (0.171398); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        84  (0.00468515); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.27s 00:00:00.91 Elapsed: 00:00:00.46
# Mc/sec: 1705.75
//
Query:       EFC39022.1  [L=258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.6e-29  100.4   8.1      2e-05   24.4   0.1    5.8  5  NHL         NHL repeat
    0.00014   21.9   0.0        3.3    7.9   0.0    4.4  5  TGT_C2      Patch-forming domain C2 of tRNA-guanine transglyc
     0.0019   18.1   0.2         60    3.6   0.1    4.2  4  DUF1236     Protein of unknown function (DUF1236)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.1   3.4e-09     2e-05       4      27 ..       9      32 ..       8      33 .. 0.93
   2 !   22.5   0.1   1.3e-08     8e-05       1      27 [.      61      86 ..      61      87 .. 0.94
   3 !   18.1   0.0   3.3e-07     0.002       1      27 [.     116     142 ..     116     143 .. 0.95
   4 !   13.6   0.1   8.9e-06     0.053      12      27 ..     182     197 ..     172     198 .. 0.87
   5 !   22.5   0.0   1.3e-08   7.7e-05       2      27 ..     228     253 ..     227     254 .. 0.85

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 3.4e-09
                EEEEEEETTTEEEEEECCCTEEEE CS
         NHL  4 PhGvavdsnGdiyVaDsenhrvqv 27
                P++v v+sn++i++aD++nhr+++
  EFC39022.1  9 PTCVFVSSNDEIFIADCNNHRIRK 32
                99999*****************97 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 1.3e-08
                BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenhrvqv 27
                +nyP+Gv v+   ++y+aD++nhr+++
  EFC39022.1 61 LNYPNGVFVV-KEEVYIADYHNHRIRK 86
                79*******5.**************86 PP

  == domain 3  score: 18.1 bits;  conditional E-value: 3.3e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP++v v+ nG++y++D+ n+rv++
  EFC39022.1 116 LNYPTSVFVSENGEVYISDYLNNRVRK 142
                 79***********************86 PP

  == domain 4  score: 13.6 bits;  conditional E-value: 8.9e-06
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 n ++y++Ds nhr+++
  EFC39022.1 182 NEEVYITDSANHRIRK 197
                 679***********86 PP

  == domain 5  score: 22.5 bits;  conditional E-value: 1.3e-08
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n+P ++ v+snG+iy++Ds+n+r+++
  EFC39022.1 228 NCPMSTFVNSNGEIYITDSNNFRIRK 253
                 666666699***************86 PP

>> TGT_C2  Patch-forming domain C2 of tRNA-guanine transglycosylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0   0.00056       3.3      30      71 .]      26      64 ..       6      64 .. 0.81
   2 ?   -2.2   0.0      0.81   4.9e+03      30      41 ..      80      91 ..      69      98 .. 0.71
   3 ?    3.7   0.0     0.011        66      31      67 ..     137     171 ..     121     175 .. 0.77
   4 ?    3.8   0.0     0.011        63      19      40 ..     180     201 ..     177     225 .. 0.85
   5 ?    0.1   0.0      0.15   9.1e+02      23      38 ..     240     255 ..     232     257 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00056
      TGT_C2 30 atgrirqvlvdgerlatlraqdgrltLsleGarrlheslppP 71
                +  rir++  ++++++t+ a +g l +s  G+  ++  l +P
  EFC39022.1 26 NNHRIRKL--NNQKIMTV-AGNGELGFSSDGGLAINAKLNYP 64
                66788876..8999***7.*****************999988 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.81
      TGT_C2 30 atgrirqvlvdg 41
                   rir+v  +g
  EFC39022.1 80 HNHRIRKVSNNG 91
                567888887665 PP

  == domain 3  score: 3.7 bits;  conditional E-value: 0.011
      TGT_C2  31 tgrirqvlvdgerlatlraqdgrltLsleGarrlhes 67 
                  +r+r+vl +g+ ++t+ a +g l  s  G+  ++  
  EFC39022.1 137 NNRVRKVLQNGN-IVTI-AGNGKLGCSGDGGLAINAE 171
                 68******9886.6776.8999999998888877765 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.011
      TGT_C2  19 Lfpedvtitrsatgrirqvlvd 40 
                 +f+e+v it sa  rir+v   
  EFC39022.1 180 VFNEEVYITDSANHRIRKVSKS 201
                 58899*************9864 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.15
      TGT_C2  23 dvtitrsatgrirqvl 38 
                 ++ it s+  rir+vl
  EFC39022.1 240 EIYITDSNNFRIRKVL 255
                 4778999*******97 PP

>> DUF1236  Protein of unknown function (DUF1236)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.011        64      41      60 ..      11      30 ..       2      32 .. 0.85
   2 ?    3.6   0.1      0.01        60      44      60 ..      68      84 ..      59      88 .. 0.89
   3 ?    1.9   0.0     0.035   2.1e+02      43      60 ..     178     195 ..     171     199 .. 0.88
   4 ?    3.1   0.0     0.015        88      42      64 ..     233     255 ..     225     256 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.011
     DUF1236 41 yrYvvvndrtviVdpqtrri 60
                  +v  nd++ i d +++ri
  EFC39022.1 11 CVFVSSNDEIFIADCNNHRI 30
                568999*************9 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.01
     DUF1236 44 vvvndrtviVdpqtrri 60
                +vv+++++i d +++ri
  EFC39022.1 68 FVVKEEVYIADYHNHRI 84
                89**************9 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.035
     DUF1236  43 YvvvndrtviVdpqtrri 60 
                  +v n++++i d  ++ri
  EFC39022.1 178 VFVFNEEVYITDSANHRI 195
                 5799*************9 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.015
     DUF1236  42 rYvvvndrtviVdpqtrriVevi 64 
                  +v  n++++i d +++ri +v+
  EFC39022.1 233 TFVNSNGEIYITDSNNFRIRKVL 255
                 68999*************97665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       500  (0.0278878); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1650.65
//
Query:       EFC39023.1  [L=285]
Description: FabG domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.2e-16   59.9   0.0    9.8e-15   54.5   0.0    2.2  2  adh_short     short chain dehydrogenase
    1.3e-11   44.6   0.0    2.3e-11   43.7   0.0    1.3  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    2.1e-05   24.5   0.0    5.2e-05   23.2   0.0    1.7  2  KR            KR domain
     0.0025   17.0   0.0     0.0035   16.5   0.0    1.2  1  PAE           Pectinacetylesterase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.5   0.0   2.2e-18   9.8e-15       1     137 [.       4     144 ..       4     153 .. 0.83
   2 ?    3.1   0.0     0.013        57     160     188 ..     179     207 ..     171     211 .. 0.88

  Alignments for each domain:
  == domain 1  score: 54.5 bits;  conditional E-value: 2.2e-18
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGGCS CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfsels 97 
                 k +l +G++sGIGra+a ++a++ ++v +++rsee+ +e+++e+k++  + k+ +i+vD + ++++e++ e+ ++++++ld  v   Gi+ ++   +++
  EFC39023.1   4 KQALCVGGTSGIGRALAIKFASQKFNVSIMGRSEEAGKEIIEEMKKLnpEGKFEMIKVDASLMKDIEKVCEEYKQNHDRLDYCVLSQGIASMNG--RTE 100
                 57899******************************************9999**************************************54443..444 PP

                 HHH.HHHHHHHHTHHHHHHHHHHHHHHH...HCTTEEEEEEEEG CS
   adh_short  98 eee.wervievNltgvflltravlpaml...kqssGrIvnvsSv 137
                  +e ++  +++ + g ++ +r++ + +    k+s  r+ +v S 
  EFC39023.1 101 TKEgIDVKLALHYYGRVMFVRQLQDLLRltsKNSDVRVLTVLSA 144
                 44447777888888888888777666656556666666666665 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.013
                 HHHHHHHHGGGTEEEEEEEESSBSSHHHH CS
   adh_short 160 trslakelaptgirvnavaPGlvdTdmak 188
                 +++l+ke  +++i  +  aPG+++T+  +
  EFC39023.1 179 MDQLSKEEGNQNIAFIHQAPGFIATQWGR 207
                 578999*******************9765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.7   0.0   5.1e-15   2.3e-11       3     118 ..      12     128 ..      10     152 .. 0.81

  Alignments for each domain:
  == domain 1  score: 43.7 bits;  conditional E-value: 5.1e-15
                   TTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE.E..EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH-HHHH CS
  adh_short_C2   3 asgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgae.v..lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpfletsreef 95 
                    sgIGra+A ++a++  +v ++ ++eea k+ +ee+++  ++  +  +++D++  +++e++ ee ++++++lD++v + gia   +g+  + ++e++
    EFC39023.1  12 TSGIGRALAIKFASQKFNVSIMGRSEEAgKEIIEEMKKLNPEGkFemIKVDASLMKDIEKVCEEYKQNHDRLDYCVLSQGIASM-NGR--TETKEGI 105
                   69**************************8887777777655434455************************************9.555..5679999 PP

                   HHHHHHHTHHHHHHHHHHHHHCT CS
  adh_short_C2  96 draldvnlyslfllakaalplmk 118
                   d  l+   y+ ++++++++ l++
    EFC39023.1 106 DVKLALHYYGRVMFVRQLQDLLR 128
                   **********9999999998443 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.0   1.2e-08   5.2e-05       4      92 ..       7      93 ..       5     143 .. 0.85
   2 ?   -1.3   0.0       0.4   1.8e+03      80     107 ..     162     189 ..     115     192 .. 0.73

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 1.2e-08
                EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE----- CS
          KR  4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvl 92
                l +GG+ g+G++la   a++ + ++ +++Rs++a ++  +++++l+  + + e++++D s  +++e++ ee+k++++++  ++ + g++
  EFC39023.1  7 LCVGGTSGIGRALAIKFASQ-KFNVSIMGRSEEAGKEIIEEMKKLNP-EGKFEMIKVDASLMKDIEKVCEEYKQNHDRLDYCVLSQGIA 93
                679*************9988.57899*****5555555555555554.449************************99999888776665 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.4
                 S---EEEE---------TTT--HHHHHH CS
          KR  80 ppikGvihaAgvlrdklleemtaedleq 107
                  ++k    aAg+ +d +++++++e+ +q
  EFC39023.1 162 FTLKNAADAAGFYNDLAMDQLSKEEGNQ 189
                 5777778889999999999888887665 PP

>> PAE  Pectinacetylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   7.7e-07    0.0035      96     191 ..      76     177 ..      55     205 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 7.7e-07
         PAE  96 ynwNrvkvrYC...dg.asfsGdveev...dkstklyFrGqrilqaviedLlekglkkakkvlLsGcSAGglaailhcdklrellpkeakvkclsda.G 186
                 y+ N+ ++ YC   +g as +G +e++   d +  l++ G+ ++   ++dLl+   k+++  +L+  SAG  + ++++d+l   l+++ ++k+ +da G
  EFC39023.1  76 YKQNHDRLDYCvlsQGiASMNGRTETKegiDVKLALHYYGRVMFVRQLQDLLRLTSKNSDVRVLTVLSAGVHSPYTKLDDLD--LKHNFTLKNAADAaG 172
                 55566666666443122566777763324477889*********************************************97..8999*****999638 PP

         PAE 187 fFlda 191
                 f+ d 
  EFC39023.1 173 FYNDL 177
                 88765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       639  (0.0356406); expected 358.6 (0.02)
Passed bias filter:                      525  (0.0292822); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 1836.92
//
Query:       EFC39024.1  [L=514]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        4.5    7.3  10.9         24    5.0   3.7    3.3  3  cEGF      Complement Clr-like EGF-like


Domain annotation for each model (and alignments):
>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0    0.0018        32      14      22 ..      66      74 ..      60      74 .. 0.90
   2 ?   -0.0   0.3      0.05   8.9e+02      17      22 ..     108     113 ..     107     113 .. 0.86
   3 ?    5.0   3.7    0.0014        24       1      10 [.     208     218 ..     208     222 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0018
                ETTTEEEE- CS
        cEGF 14 pdGrsCtDI 22
                pdG sC+D+
  EFC39024.1 66 PDGFSCEDV 74
                8*******8 PP

  == domain 2  score: -0.0 bits;  conditional E-value: 0.05
                 TEEEE- CS
        cEGF  17 rsCtDI 22 
                 r+C+D+
  EFC39024.1 108 RTCIDV 113
                 9****8 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0014
                 SEEEE-S.TTE CS
        cEGF   1 SYrCsCp.pGY 10 
                 SY+C+C  +GY
  EFC39024.1 208 SYYCTCLsNGY 218
                 9*****98888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1239  (0.0691059); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 3264.95
//
Query:       EFC39025.1  [L=318]
Description: hypothetical protein NAEGRDRAFT_59386 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0022   18.3   8.1     0.0022   18.3   8.1    1.9  2  DUF641        Plant protein of unknown function (DUF641)
  ------ inclusion threshold ------
       0.03   14.0   5.3      0.061   12.9   5.3    1.5  1  Phage_GPO     Phage capsid scaffolding protein (GPO) serine p
        1.8    7.9  20.6      0.034   13.6  13.1    1.8  2  HMMR_N        Hyaluronan mediated motility receptor N-termina
        1.9    9.4  14.4       0.68   10.9   5.0    2.9  3  Fes1          Nucleotide exchange factor Fes1
        2.6    7.7  16.2      0.031   14.0   7.2    2.3  3  CCDC106       Coiled-coil domain-containing protein 106
        2.8    8.3  18.2      0.079   13.3   3.0    3.3  3  Csm1_N        Csm1 N-terminal domain
        4.1    7.7  15.1       0.62   10.3  10.8    1.9  2  Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
        4.7    7.9   9.7        1.5    9.5   6.2    2.0  2  SlyX          SlyX


Domain annotation for each model (and alignments):
>> DUF641  Plant protein of unknown function (DUF641)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1         1   2.2e+03     104     121 ..      49      66 ..      13      95 .. 0.74
   2 !   18.3   8.1     1e-06    0.0022      55     123 ..     233     300 ..     228     305 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1
      DUF641 104 kdseieeLkekLeeaeks 121
                 k+ e+++L e+++ +++s
  EFC39025.1  49 KEDEVKQLYESFQVQNES 66 
                 555666665555554443 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 1e-06
      DUF641  55 elkrlyrkkqkkkaseaeeseleaeiqeqrsllktyeitvkkleaelkakdseieeLkekLeeaeksnk 123
                 +lk l+  ++kkk++ +e+++ e+++q  ++ ++ y++ +++l ++l ++d ei++Lk+++++ e + +
  EFC39025.1 233 KLKALFSVEEKKKKK-KEKAKTERKVQSIQEQMNKYNKIISSLYKDLIERDLEIQQLKQQVAQFEDNLS 300
                 799999999888876.99******************************************999887655 PP

>> Phage_GPO  Phage capsid scaffolding protein (GPO) serine peptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   5.3   2.7e-05     0.061     171     257 ..     225     308 ..     186     314 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.7e-05
   Phage_GPO 171 eeegeslferikallskkkksd.darfadveeavelvAeevkelsekveallaleaelaalkkeveklkaeleaLkekLsktdakekq 257
                 +e  ++  +++kal+s ++k++ +++ a++e+ v+ + e+++++++ ++   +l ++l + + e+++lk+++++++++Ls+t++++++
  EFC39025.1 225 SEP-MASPRKLKALFSVEEKKKkKKEKAKTERKVQSIQEQMNKYNKIIS---SLYKDLIERDLEIQQLKQQVAQFEDNLSTTEDEHTE 308
                 444.556689*****987766637889999****************999...77789999999999***************9997765 PP

>> HMMR_N  Hyaluronan mediated motility receptor N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.8      0.87     2e+03      52      84 ..      20      52 ..       2      77 .. 0.53
   2 ?   13.6  13.1   1.5e-05     0.034     220     294 ..     241     314 ..     229     318 .] 0.80

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.87
      HMMR_N 52 arkvsvlelkkaksqkkdkskltkekkkqkeLE 84
                ++ ++ l+ +++  ++k  +++t   k +ke E
  EFC39025.1 20 QSFMNQLKVEEPIVKRKRGNSMTFRFKSLKEDE 52
                223344455555666666666666666666433 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 1.5e-05
      HMMR_N 220 ieekseteklleyieelsnvseqlekykldiaqleellkekndeiesLkssLeekeqelskqvkdlnekckllek 294
                 +e+k++ ++  +   ++++++eq++ky++ i +l   l e++ ei++Lk+++ + e++ls++ +d +++ ++le+
  EFC39025.1 241 EEKKKKKKEKAKTERKVQSIQEQMNKYNKIISSLYKDLIERDLEIQQLKQQVAQFEDNLSTT-EDEHTETEELES 314
                 3445555666667789*****************************************88865.666666777776 PP

>> Fes1  Nucleotide exchange factor Fes1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.2     0.026        59      17      59 ..      50      92 ..       3     116 .. 0.62
   2 ?   -3.2   0.1       7.5   1.7e+04      36      36 ..     155     155 ..     140     182 .. 0.50
   3 ?   10.9   5.0    0.0003      0.68       7      82 ..     238     314 ..     234     318 .] 0.78

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.026
        Fes1 17 asaseqeaesaaeaakask.ekldpeildallggpsdaelmkea 59
                +++ +q  es++ ++++ +   l++e   ++++ p +ael+k+ 
  EFC39025.1 50 EDEVKQLYESFQVQNESGRqYGLTSEDFMQIFE-PLQAELIKQL 92
                344445555555566666667778888888888.8888888764 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 7.5
        Fes1  36 e 36 
                 +
  EFC39025.1 155 S 155
                 1 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 0.0003
        Fes1   7 Wsienstaedasaseqeaesaaeaakask.ekldpeildallggpsdaelmkeamevledeevtlenkliAldnleq 82 
                 +s+e++++++++++++e + ++ +++++k +k+ +++++ l++   + +++k++++ +ed+ +t+e+  +  ++le+
  EFC39025.1 238 FSVEEKKKKKKEKAKTERKVQSIQEQMNKyNKIISSLYKDLIERDLEIQQLKQQVAQFEDNLSTTEDEHTETEELES 314
                 79998766666666666666666667778899999999999**999***************7777777777777765 PP

>> CCDC106  Coiled-coil domain-containing protein 106
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.9      0.99   2.2e+03      72     102 ..       8      36 ..       2      64 .. 0.41
   2 ?   -0.5   0.1      0.37   8.3e+02      55      96 ..     154     191 ..     140     206 .. 0.56
   3 ?   14.0   7.2   1.4e-05     0.031      45     141 ..     179     274 ..     168     279 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.99
     CCDC106  72 ssssseesddsssdssessessegsstekkk 102
                 s s+s +s+++++ s ++  + e +   k+k
  EFC39025.1   8 SPSASTTSNKDEQ-SFMNQLKVEEP-IVKRK 36 
                 2222333322222.22222222222.22222 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.37
     CCDC106  55 eskskksekkaeksesessssseesddsssdssessessegs 96 
                 +   ++  +++ +  ++++ss+e s+ +s+ s +s ++++++
  EFC39025.1 154 T---SSLTREHSFPPTITTSSEEISTCESM-SPVSPSNDHSP 191
                 2...22333345567778888888888877.66666665554 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 1.4e-05
     CCDC106  45 sksleaeaekeskskksekkaeksesessssseesddsssdssessessegsstekkkkkkkk.kekkkkkktkkrerkrvkdvddvliRykkvLttf 141
                 s+s  ++++++s  + +++++e s+ +    +++  +ss    ++ ++se  ++ +k k     +ekkkkkk+k++  ++v+  ++ +++y+k++++ 
  EFC39025.1 179 SMSPVSPSNDHSPIHVTPQQTERSKLFIPIPNSNHRNSSE--FDNDTWSEPMASPRKLKALFSvEEKKKKKKEKAKTERKVQSIQEQMNKYNKIISSL 274
                 5555577777777777777766666555444333333333..445555665555666555555699****************************9875 PP

>> Csm1_N  Csm1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1      0.28   6.3e+02      29      56 ..      39      66 ..      28      74 .. 0.75
   2 ?    1.3   4.3       0.2   4.5e+02      26      59 ..     240     273 ..     238     277 .. 0.77
   3 ?   13.3   3.0   3.5e-05     0.079      32      69 ..     274     311 ..     272     312 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.28
      Csm1_N 29 NsvLsqkletkdqeiesLkeqlaeleek 56
                Ns+  +  + k++e+++L e  +  +e 
  EFC39025.1 39 NSMTFRFKSLKEDEVKQLYESFQVQNES 66
                5555555677899999998887776665 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.2
      Csm1_N  26 vhENsvLsqkletkdqeiesLkeqlaeleekvke 59 
                 v+E   ++++  + +++++s++eq+++ ++ +++
  EFC39025.1 240 VEEKKKKKKEKAKTERKVQSIQEQMNKYNKIISS 273
                 5677777778888889999999999998876665 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 3.5e-05
      Csm1_N  32 LsqkletkdqeiesLkeqlaeleekvkeleerrkkqeE 69 
                 L ++l  +d ei++Lk+q+a+ e +++ +e+++++ eE
  EFC39025.1 274 LYKDLIERDLEIQQLKQQVAQFEDNLSTTEDEHTETEE 311
                 6678889************************9999988 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1         3   6.8e+03      20      43 ..      34      57 ..      23      66 .. 0.48
   2 ?   10.3  10.8   0.00028      0.62      27      93 ..     239     309 ..     228     314 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 3
                  CCTCCCHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N 20 kRgedkadvdelleldekrrelqv 43
                  kR++ ++   ++ +l e   +   
    EFC39025.1 34 KRKRGNSMTFRFKSLKEDEVKQLY 57
                  444444444444444444444443 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00028
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCTT....S-TCCCCCCCHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  27 dvdelleldekrrelqveleelqaerNelskeIgkakkkk....edaeeliaevkelkeelkaleaelkel 93 
                    v+e  +  +++ +++ +++++q++ N+ +k I+++ k+      ++++l+++v++  ++l+++e+e +e 
    EFC39025.1 239 SVEEKKKKKKEKAKTERKVQSIQEQMNKYNKIISSLYKDLierdLEIQQLKQQVAQFEDNLSTTEDEHTET 309
                   5777778889999999*********************9776555666666666666666666666666555 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.1         8   1.8e+04      38      52 ..      51      65 ..      49      69 .. 0.61
   2 ?    9.5   6.2   0.00067       1.5       2      58 ..     254     310 ..     253     315 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 8
                HHHHHHHHT-XXXXX CS
        SlyX 38 rqlrllaerlkelee 52
                 ++++l+e ++  +e
  EFC39025.1 51 DEVKQLYESFQVQNE 65
                467777777755444 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00067
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXX CS
        SlyX   2 eerleeLEiklafqedtieeLndvvaeqqqqidrlqrqlrllaerlkeleessgase 58 
                 e +++ +++++    + i +L + ++e + +i++l++q+++ +++l++ e+++ ++e
  EFC39025.1 254 ERKVQSIQEQMNKYNKIISSLYKDLIERDLEIQQLKQQVAQFEDNLSTTEDEHTETE 310
                 67889999999999********************************99999877554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3366  (0.187741); expected 358.6 (0.02)
Passed bias filter:                      861  (0.0480228); expected 358.6 (0.02)
Passed Vit filter:                       115  (0.00641419); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.79u 0.38s 00:00:01.17 Elapsed: 00:00:00.57
# Mc/sec: 1675.12
//
Query:       EFC39026.1  [L=959]
Description: hypothetical protein NAEGRDRAFT_81452 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.7e-29   98.7  19.0      3e-08   33.3   0.6    7.1  8  NHL           NHL repeat
    1.3e-05   25.0   0.3      0.029   14.0   0.0    4.2  5  SGL           SMP-30/Gluconolactonase/LRE-like region
    5.2e-05   23.1   3.8       0.21   11.5   0.0    4.0  4  DUF4934       Domain of unknown function (DUF4934)
    7.5e-05   22.0  17.0      0.016   14.4   1.0    4.5  5  DUF5128       6-bladed beta-propeller
    0.00069   19.7  13.4    0.00069   19.7  13.4    2.4  2  zf-B_box      B-box zinc finger
     0.0011   19.0   0.0        0.1   12.5   0.0    2.8  2  Phytase-like  Esterase-like activity of phytase
  ------ inclusion threshold ------
       0.13   12.8   0.2        4.7    7.8   0.0    3.0  2  PQQ_3         PQQ-like domain
        5.5    6.6  12.0         44    3.7   8.5    2.4  2  YkyA          Putative cell-wall binding lipoprotein


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.4   0.1   2.6e-11   5.9e-08       1      28 []     691     718 ..     691     718 .. 0.98
   2 ?   -0.5   0.0      0.71   1.6e+03       4      18 ..     733     748 ..     732     754 .. 0.87
   3 ?   -2.4   0.0       2.7     6e+03       1       9 [.     777     785 ..     777     792 .. 0.82
   4 !   14.3   0.0   1.4e-05     0.031      13      28 .]     794     809 ..     793     809 .. 0.92
   5 !   22.1   0.3   4.6e-08    0.0001       1      28 []     833     860 ..     833     860 .. 0.98
   6 ?   -2.1   0.0       2.3   5.1e+03       2       8 ..     880     886 ..     880     891 .. 0.83
   7 ?    3.9   0.0     0.027        61      17      27 ..     899     909 ..     894     910 .. 0.89
   8 !   33.3   0.6   1.4e-11     3e-08       1      28 []     931     958 ..     931     958 .. 0.98

  Alignments for each domain:
  == domain 1  score: 32.4 bits;  conditional E-value: 2.6e-11
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f++P+++a+d++++i+++D+en+rvq+F
  EFC39026.1 691 FSSPTDIAIDPSDNIIICDNENNRVQIF 718
                 899************************9 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.71
                 EEEEEEE.TTTEEEEE CS
         NHL   4 PhGvavd.snGdiyVa 18 
                 P Gv+ d + G i+V+
  EFC39026.1 733 PYGVTFDaKEGVILVT 748
                 5599***999999997 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 2.7
                 BSSEEEEEE CS
         NHL   1 fnyPhGvav 9  
                 f+yP+G+ v
  EFC39026.1 777 FSYPTGIIV 785
                 899*99965 PP

  == domain 4  score: 14.3 bits;  conditional E-value: 1.4e-05
                 TEEEEEECCCTEEEEE CS
         NHL  13 GdiyVaDsenhrvqvF 28 
                 G i+V+D +nhr+q F
  EFC39026.1 794 GKIIVCDHHNHRIQMF 809
                 89***********965 PP

  == domain 5  score: 22.1 bits;  conditional E-value: 4.6e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f+ P+++ +d +G+++++D++n rvqvF
  EFC39026.1 833 FYGPNSLDIDIDGNLVITDRYNCRVQVF 860
                 899************************9 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 2.3
                 SSEEEEE CS
         NHL   2 nyPhGva 8  
                 ++P+G++
  EFC39026.1 880 CDPTGIC 886
                 89****9 PP

  == domain 7  score: 3.9 bits;  conditional E-value: 0.027
                 EEECCCTEEEE CS
         NHL  17 VaDsenhrvqv 27 
                 ++D+ n+r+q+
  EFC39026.1 899 ICDYANNRIQI 909
                 8*********8 PP

  == domain 8  score: 33.3 bits;  conditional E-value: 1.4e-11
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 f  P+Gv+++s G+++V D++nhrvq+F
  EFC39026.1 931 FDGPNGVSITSEGHLVVVDYHNHRVQIF 958
                 889************************9 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.0   0.0   1.3e-05     0.029     189     232 ..     697     738 ..     676     750 .. 0.83
   2 ?    1.2   0.0       0.1   2.3e+02     188     219 ..     735     766 ..     732     774 .. 0.86
   3 ?    1.0   0.0      0.11   2.6e+02     185     218 ..     779     817 ..     742     828 .. 0.58
   4 ?    2.9   0.0      0.03        67     186     229 ..     836     879 ..     819     888 .. 0.84
   5 ?   -0.0   0.0      0.24   5.3e+02     183     210 ..     930     958 ..     896     959 .] 0.75

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.3e-05
         SGL 189 lavDaeGnvwvAvwgggkvvrfdpdGklieeiklpakrvtscaF 232
                 +a+D ++n++++  ++++v+ fd++Gk +++ ++p  ++  ++F
  EFC39026.1 697 IAIDPSDNIIICDNENNRVQIFDKQGKFLRKFSVP--KPYGVTF 738
                 89*********************************..5555555 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.1
         SGL 188 GlavDaeGnvwvAvwgggkvvrfdpdGkliee 219
                 G++ Da+ +v+  + ++++v  fd+ G+ +++
  EFC39026.1 735 GVTFDAKEGVILVTSDDHCVYAFDKSGTEVGK 766
                 8999**888999999***********998875 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.11
         SGL 185 epDGlavDae.....GnvwvAvwgggkvvrfdpdGklie 218
                 +p G++v ++     G+++v+  ++++++ fd+ G+ ++
  EFC39026.1 779 YPTGIIVSETksqipGKIIVCDHHNHRIQMFDKYGSFLK 817
                 445555443222333788888888888888888877666 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.03
         SGL 186 pDGlavDaeGnvwvAvwgggkvvrfdpdGklieeiklpakrvts 229
                 p +l +D +Gn+ ++   + +v++f+ dG+ +++ +++ +  + 
  EFC39026.1 836 PNSLDIDIDGNLVITDRYNCRVQVFTLDGTFVRKFSVKKQENSE 879
                 778899***************************99999555555 PP

  == domain 5  score: -0.0 bits;  conditional E-value: 0.24
         SGL 183 e..gepDGlavDaeGnvwvAvwgggkvvrf 210
                 +  g p G+ +++eG++ v  +++++v+ f
  EFC39026.1 930 QfdG-PNGVSITSEGHLVVVDYHNHRVQIF 958
                 2423.8889999999999999999999876 PP

>> DUF4934  Domain of unknown function (DUF4934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   0.0   9.5e-05      0.21      49     101 ..     672     725 ..     650     726 .. 0.86
   2 ?    3.3   0.1     0.033        75      34      69 ..     743     778 ..     736     791 .. 0.72
   3 !    7.0   0.1    0.0024       5.3      35      68 ..     795     829 ..     781     868 .. 0.63
   4 ?   -3.5   0.0       4.3   9.7e+03      37      74 ..     900     937 ..     889     953 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 9.5e-05
     DUF4934  49 ketGkflasvGhiGedPegy.sevagwlndatgllyfsrkpdklvkydakGefl 101
                 k +Gkf+   G +G +   + s +   ++++++++   +++++++++d++G+fl
  EFC39026.1 672 KIEGKFVLGFGGKGTEDGQFsSPTDIAIDPSDNIIICDNENNRVQIFDKQGKFL 725
                 679*********9965555505568899************************95 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.033
     DUF4934  34 dkivvsskkqC.llfdketGkflasvGhiGedPegys 69 
                   i+v+s+++C ++fdk +G  + + G +G +   +s
  EFC39026.1 743 GVILVTSDDHCvYAFDK-SGTEVGKFGSKGAEYGHFS 778
                 56899999999457887.5777888888887665555 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0024
     DUF4934  35 kivvss..kkqCllfdketGkflasvGhiGedPegy 68 
                 ki+v    +++ ++fdk  G fl+s G  G +Pe  
  EFC39026.1 795 KIIVCDhhNHRIQMFDK-YGSFLKSFGTNGTNPEME 829
                 45555446789999998.59*************953 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 4.3
     DUF4934  37 vvsskkqCllfdketGkflasvGhiGedPegysevagw 74 
                   +++++ ++++ ++G  +++ G  G +   +   +g+
  EFC39026.1 900 CDYANNRIQIWNLREGVIIKQFGCYGSEDGQFDGPNGV 937
                 55567777788888888888888888665555555444 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       2.5   5.7e+03      51      79 ..      62      89 ..      59      90 .. 0.61
   2 ?   -0.9   0.3      0.32   7.2e+02     216     273 ..     464     518 ..     457     560 .. 0.74
   3 !   12.9   0.2     2e-05     0.044      63      87 ..     703     727 ..     686     731 .. 0.84
   4 ?    3.3   0.1     0.016        37      65     113 ..     745     792 ..     736     794 .. 0.85
   5 !   14.4   1.0   7.2e-06     0.016      63     139 ..     794     872 ..     791     913 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 2.5
     DUF5128 51 ligeiskikvvdkrifvlDsaknn.lfvFd 79
                 i +++++  +++   +lD+++++ l  F+
  EFC39026.1 62 IIDNVKQVDESEE--CILDERRPQaLHLFS 89
                4455555555555..567999977699886 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.32
     DUF5128 216 nevYkikdkelkpayefdfggkknpeieflkkketkgkeeflkkllssdlisyfnlle 273
                 +evY+ +++elk  + f+   ++n++ ++ k +++kg    ++++  + + + f++le
  EFC39026.1 464 EEVYQKEKQELKNQI-FQM--QQNISEKMEKLARDKGTISHTYEDGVKSINENFDILE 518
                 677887777777655.333..4677777777777777777777776666655555555 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 2e-05
     DUF5128  63 krifvlDsaknnlfvFdkkGkfvrk 87 
                 + i++ D+ +n++ +Fdk+Gkf rk
  EFC39026.1 703 DNIIICDNENNRVQIFDKQGKFLRK 727
                 789*******************998 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.016
     DUF5128  65 ifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesI 113
                 i+v  s +  ++ Fdk+G  v k g++G   g + + + +i+ + + +I
  EFC39026.1 745 ILV-TSDDHCVYAFDKSGTEVGKFGSKGAEYGHFSYPTGIIVSETKSQI 792
                 555.344455********************************9999887 PP

  == domain 5  score: 14.4 bits;  conditional E-value: 7.2e-06
     DUF5128  63 krifvlDsaknnlfvFdkkGkfvrkIgaqGeGP...gE.YlqindfiidksnesIyildfmknkiltYdLegykfieekkl 139
                 ++i+v D  + ++  Fdk G f +  g  G  P   g  +   n+  id +  ++ i d+ + ++ ++ L+g  f+++  +
  EFC39026.1 794 GKIIVCDHHNHRIQMFDKYGSFLKSFGTNGTNPemeGGyFYGPNSLDIDIDG-NLVITDRYNCRVQVFTLDG-TFVRKFSV 872
                 79*******************************4442425569******666.7888*************99.99887555 PP

>> zf-B_box  B-box zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7  13.4   3.1e-07   0.00069       5      40 ..     425     461 ..     423     463 .. 0.93
   2 ?   -0.6   0.3      0.69   1.5e+03       5      16 ..     798     808 ..     795     809 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 3.1e-07
    zf-B_box   5 kCpeHknkpatlfCedCqq.plCeeCstgeHrgHevv 40 
                 +C+ Hk+++++ +C++C+  ++C+ C  ++H+gH+++
  EFC39026.1 425 CCETHKDQKLNTWCHTCGDeLICAICAISKHKGHDCD 461
                 7****************988**************986 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.69
    zf-B_box   5 kCpeHknkpatl 16 
                 +C++H+ ++++ 
  EFC39026.1 798 VCDHHN-HRIQM 808
                 688888.76665 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.0   4.7e-05       0.1      72     113 ..     696     737 ..     683     761 .. 0.92
   2 ?    3.6   0.0     0.023        53      70     112 ..     836     878 ..     735     897 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.7e-05
  Phytase-like  72 giavapdgtfwvssEggpfilefdadGkllrelplpaellpa 113
                   +ia++p +++++++  ++++  fd++Gk+lr++++p+ + ++
    EFC39026.1 696 DIAIDPSDNIIICDNENNRVQIFDKQGKFLRKFSVPKPYGVT 737
                   599*********************************998665 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.023
  Phytase-like  70 pEgiavapdgtfwvssEggpfilefdadGkllrelplpaellp 112
                   p ++ ++ dg++++++ ++ ++  f++dG++ r+++++++ + 
    EFC39026.1 836 PNSLDIDIDGNLVITDRYNCRVQVFTLDGTFVRKFSVKKQENS 878
                   557778889999999999999*********9999999887654 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0    0.0021       4.7      17      37 ..     736     758 ..     726     760 .. 0.74
   2 ?    1.0   0.1      0.29   6.6e+02      17      31 ..     937     953 ..     924     956 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0021
       PQQ_3  17 pavd..gglvyvgtgdGtlyAlD 37 
                 +++d  +g++ v+++d+ +yA+D
  EFC39026.1 736 VTFDakEGVILVTSDDHCVYAFD 758
                 4444338***************9 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.29
       PQQ_3  17 p.avdgglvyvgtg.dG 31 
                 +  +++g+++v+++ ++
  EFC39026.1 937 VsITSEGHLVVVDYhNH 953
                 347899******99555 PP

>> YkyA  Putative cell-wall binding lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   8.5      0.02        44      36     109 ..     461     531 ..     451     534 .. 0.77
   2 ?    3.6   1.2     0.021        47      34      65 ..     537     568 ..     518     582 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.02
        YkyA  36 elyeeiielgmdefdkikklsdealenveeReellekekesieeakee.fekikeeieeiedeelkkeaeeliea 109
                 +l ee+ ++   e++++k+++ ++++n++e+ e+l+  k  i+ ++e  +++i+e+++ + ++ l ++ +el e+
  EFC39026.1 461 DLVEEVYQK---EKQELKNQIFQMQQNISEKMEKLARDKGTISHTYEDgVKSINENFDIL-EKRLAQKRKELTEK 531
                 566777665...5556*****************************997467777777777.55577777777665 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.021
        YkyA  34 eqelyeeiielgmdefdkikklsdealenvee 65 
                 e e+ e+i++ gm+++++ik l d   en+++
  EFC39026.1 537 EDEICEKILNSGMQQLSQIKFLTDGFMENLSK 568
                 889*********************99999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (959 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1997  (0.111384); expected 358.6 (0.02)
Passed bias filter:                      620  (0.0345808); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.12u 0.37s 00:00:01.49 Elapsed: 00:00:00.58
# Mc/sec: 5009.12
//
Query:       EFC39027.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.9e-22   77.8   0.3    1.3e-21   77.2   0.3    1.3  1  TLD       TLD
  ------ inclusion threshold ------
       0.11   13.5   0.7       0.23   12.4   0.7    1.5  1  DUF4834   Domain of unknown function (DUF4834)
       0.23   10.7   1.0       0.35   10.1   1.0    1.2  1  MSP1a     Major surface protein 1a (MSP1a)


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.2   0.3   2.2e-25   1.3e-21       1     138 [.     148     293 .]     148     293 .] 0.90

  Alignments for each domain:
  == domain 1  score: 77.2 bits;  conditional E-value: 2.2e-25
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl.....spkfkvykstgknkaylntssdg.....lgf 89 
                 lly++skdg++++++++k++n+gpt+++ik + + ifG+++s +w+s+  +f+ ds+ flfsl     + +fk + + g  +ay+n s +      ++f
  EFC39027.1 148 LLYNASKDGFRARSFHSKCDNQGPTVTIIKASSGAIFGGYTSVSWSSAMLDFFPDSKAFLFSLigpkrDERFKKLIQDGPHSAYVNYSVYHrsvdhPTF 246
                 79***************************************************************9999999999999999999999883355566*** PP

         TLD  90 GggqpkfsLwidsslekgtsrhs..etfengllsgaseerfkikdiEVWgl 138
                 Ggg   ++++i    +k+ +++   +  + + l+g s+ +f   d EV++l
  EFC39027.1 247 GGG---HDIFIARGTKKSFTNPFtySNLGKDYLTG-STREFTTLDYEVYSL 293
                 *95...7**************97555555788885.9***********975 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.7   3.8e-05      0.23       6      87 ..       8     100 ..       5     108 .. 0.47

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.8e-05
     DUF4834   6 filifiiailviglsilsvilrtvfglgsrkkss.............ksaqkqfgnstnsnqqksq..............srsetkeegeiieeersek 77 
                 f+l+++++++v+ +++    + +v   g++ k++             +          +++q+  q              +r++ + + +++++ +++k
  EFC39027.1   8 FFLLLLLLLVVLSVVV----VSAV--EGKKAKGTtkasikatarlikR---------SKQQQN--QhgkkvmrkqavvvrNRNAPRVTLNANKDGNPTK 89 
                 2233333333333333....3334..2333333322222333333221.........222111..1223344455667666666666667888888888 PP

     DUF4834  78 eakrk.kiFek 87 
                 +++ k ki +k
  EFC39027.1  90 SKSVKlKILKK 100
                 77777787665 PP

>> MSP1a  Major surface protein 1a (MSP1a)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   1.0   5.8e-05      0.35      61     115 ..       9      63 ..       5      70 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 5.8e-05
       MSP1a  61 lvvLLpLlgaaaviavadesedkaagdaarvvk.eessrelsrelseDrsklkama 115
                 + +LL+Ll++ +v++v++   +ka g ++  +k   +  + s+++++ ++  k+m+
  EFC39027.1   9 FLLLLLLLVVLSVVVVSAVEGKKAKGTTKASIKaTARLIKRSKQQQNQHG-KKVMR 63 
                 56778888888888888888888888765555404444444444444333.34554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1390  (0.077528); expected 358.6 (0.02)
Passed bias filter:                      727  (0.0405488); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.27s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 1809.58
//
Query:       EFC39028.1  [L=615]
Description: Hypothetical protein NAEGRDRAFT_59388 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
       0.11   12.5   0.0       0.37   10.8   0.0    1.9  1  TPK_catalytic  Thiamin pyrophosphokinase, catalytic domain
       0.84    9.6   3.7         42    4.1   1.8    2.9  2  LBP_C          Lacto-N-biose phosphorylase C-terminal domain


Domain annotation for each model (and alignments):
>> TPK_catalytic  Thiamin pyrophosphokinase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   4.2e-05      0.37      25      86 ..     413     472 ..     371     493 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 4.2e-05
  TPK_catalytic  25 ekerlellpdvivGDlDSirpevkefyeskgteivkkpdqdstDlekaialvlekekedknk 86 
                    +++++  + d+  GD+DS+r+e+++f ++  t+  +++d ++   +k  + ++e+e+++k+k
     EFC39028.1 413 KRKSRTSVSDIKGGDIDSLREEIRKFESQ--TPQNEENDLNQEPPTKYWDEIEEEEQDRKRK 472
                    3344445568889***********98776..6777777777777777777777777666644 PP

>> LBP_C  Lacto-N-biose phosphorylase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   1.8    0.0047        42      15      32 ..     202     219 ..     201     229 .. 0.88
   2 ?    3.8   0.0     0.006        54      23      39 ..     410     426 ..     410     431 .. 0.91

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0047
       LBP_C  15 esgklvViNNsdeeqtTt 32 
                 +++k  +iN+s++e++T+
  EFC39028.1 202 KNKKNSIINHSNNEKETK 219
                 689999**********96 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.006
       LBP_C  23 NNsdeeqtTtvytgdgk 39 
                 NNs+++  T+v++ +g 
  EFC39028.1 410 NNSKRKSRTSVSDIKGG 426
                 *************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (615 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1343  (0.0749066); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.51
# Mc/sec: 3604.26
//
Query:       EFC39029.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       963  (0.0537119); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1191.77
//
Query:       EFC39030.1  [L=104]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (104 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1146  (0.0639188); expected 358.6 (0.02)
Passed bias filter:                      548  (0.030565); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.35s 00:00:00.91 Elapsed: 00:00:00.54
# Mc/sec: 580.11
//
Query:       EFC39031.1  [L=525]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-32  112.2   0.1    5.2e-32  111.7   0.1    1.2  1  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.7   0.1   2.9e-36   5.2e-32       3     208 ..     256     491 ..     254     492 .. 0.84

  Alignments for each domain:
  == domain 1  score: 111.7 bits;  conditional E-value: 2.9e-36
      DUF563   3 ygHwlvdvlprlllleqlvlddd...drilvpalaspqpfqrellkllgi.rpekrikveldepvhveklivpvppr...............ssggfqg 82 
                  +H l d+++++ ++e++ ld++   +++l  +++sp++f++++   + + rp+++ ++ ++++v++e++i+++++                +      
  EFC39031.1 256 LFHALSDFFATFQMIEMFKLDSKnvqIVLLDEHYESPYDFLWNST--FSLkRPARKASYFKEKTVRFERAIFQHAGVatqlksnlldfsefdP------ 346
                 45*********************8744444888889999999999..777679999999999**************98777764444333330...... PP

      DUF563  83 allp..........klrdrlrerlnlekrkkp........trvlyisRlkagsRrilNeeevl...kllpkrg....fevvdpeslsfeeqiklfssak 156
                    +          +++dr++++l++ek ++p        +r l++s       +i+Ne+evl   k++p++g    +e++d++++sf eq+k +++a+
  EFC39031.1 347 ---SqckskvrlvtAFSDRILSTLGIEK-RRPsfsssdemIRGLFVSS-----GKITNEDEVLinlKKHPEYGytftLERIDLNKFSFVEQVKRVHQAD 436
                 ...26666777777**************.6666666677888888888.....99*******99999999999776677******************** PP

      DUF563 157 vivgphGsgltnliFmppg.ttvielvppnrldns..fenlaallglkyayvlge 208
                 +++g+h  gltn++F+p g ++++e++ + + +    fe+ ++++g++y+++++ 
  EFC39031.1 437 FLIGYHDLGLTNSLFLPDGtSGLLEIWKTYKTRSMrsFEQYSRWKGNEYTLWTNM 491
                 ****************88659*****87754444489***************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (525 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       831  (0.0463495); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.35s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 2851.05
//
Query:       EFC39032.1  [L=402]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1351  (0.0753528); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.36s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 2204.97
//
Query:       EFC39033.1  [L=618]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00028   21.0   0.2     0.0019   18.3   0.1    2.4  2  SPRY        SPRY domain
  ------ inclusion threshold ------
      0.069   13.1   0.0       0.15   12.0   0.0    1.5  1  F-box-like  F-box-like
        1.8    7.6  14.4        3.7    6.5  14.4    1.5  1  Pes-10      Pes-10


Domain annotation for each model (and alignments):
>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       0.4   2.4e+03      21      53 ..      34      65 ..      13      79 .. 0.62
   2 !   18.3   0.1   3.3e-07    0.0019      13      89 ..     359     437 ..     349     453 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.4
                EETTSSSSSTSSSTSSTTEEEEETETTEEEEET CS
        SPRY 21 ateqtdlsdksgegddrgswglcgdngtrtsae 53
                +t q +  +++ + d++  ++++g  g++ +  
  EFC39033.1 34 TTLQQQNDNNNNNNDESSLIKYDGSFGLI-TDD 65
                44455544444445555559999988887.444 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 3.3e-07
                 SSEEEEEEEETTSSSSSTSSSTSSTTEEEEETETTEEE.....EETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTEEE CS
        SPRY  13 ggsisvGlateqtdlsdksgegddrgswglcgdngtrt.....saeqskaygkqparegdviGvalDleegelsFtkngknl 89 
                 +g  s+G+ ++++   ++++ g+d+ s g++ d++ ++     s+ + +  gk     gdv G+++    + ++Ft ng+ l
  EFC39033.1 359 DGRNSIGIMHNRYL--GNRQVGWDDLSTGFHTDDAGFFleegsSKFKVNTDGK-EIIVGDVLGCGFSSHHKAVFFTLNGTFL 437
                 56678999999999..777779**************99666533333333333.55589********************987 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   2.5e-05      0.15      26      48 .]      86     107 ..      71     107 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2.5e-05
  F-box-like  26 lVCrrWrrvaldtplLWrrlvlr 48 
                 lVC +W+++ ++t ++W+ +vl+
  EFC39033.1  86 LVCNKWKNMSNKT-SIWYDIVLK 107
                 9************.*****9985 PP

>> Pes-10  Pes-10
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  14.4   0.00062       3.7     135     203 ..     509     595 ..     495     615 .. 0.54

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.00062
      Pes-10 135 yleileraiefqeqieeAdeLvekvekllrkeei.vdEdleeeeeede...................edseeddddiededeedessss 203
                 + +++e+ + ++++ie A++  +++++ ++ +e+ +d d+e+ ee+d+                   e++ee  + ++d+  ed+s  +
  EFC39033.1 509 MSGLVEKLTSLRNRIETANQFLADIQRRILMREMgMDSDEEMTEENDRndedyvddgmelssvdsssEEEEE--HTWNDIIREDNSDAQ 595
                 4688999*******************9888888755555555555555333333333333333321111111..222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (618 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1171  (0.0653132); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.80u 0.34s 00:00:01.14 Elapsed: 00:00:00.54
# Mc/sec: 3446.77
//
Query:       EFC39034.1  [L=429]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      0.006   17.5   0.0      0.015   16.2   0.0    1.7  1  Trypsin_2        Trypsin-like peptidase domain
  ------ inclusion threshold ------
      0.016   14.9   0.7        0.5   10.2   0.7    2.6  1  Ephrin_rec_like  Putative ephrin-receptor like


Domain annotation for each model (and alignments):
>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   1.7e-06     0.015       1     141 [.     102     319 ..     102     325 .. 0.54

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 1.7e-06
   Trypsin_2   1 GsGflvgsdglilTnaHvv................................dsadgaav.......kaikkkveeagadgrevpakvvaadp....... 53 
                 +sGf+v ++  ++Tn+Hv                                 d               + ++   ++++ + +++ +++++dp       
  EFC39034.1 102 ASGFYVLPNV-VITNCHVNnklqsatgsnlcfaysnawnisnyedalarlkD------LpeqkqlfFSGQVYKDAPFPTKFKQTKEWIGRDPitgkigd 193
                 69********.********777666655555555555555544444443331......02222223233344444555666666667777778876554 PP

   Trypsin_2  54 .el.DlAllkvssderaglpplplgpsealkggepvyvvGyp..............lggeksg....................svssGivsgvve.... 112
                  ++ D+A  k  s++++++ ++p   s+ l++g++++ ++yp                    +                    ++s G++    +    
  EFC39034.1 194 fSYfDFAANKY-SGQPNNVFFIPS--STILQPGDEIITLSYPgnensvsplidyhnY-----AewaptdsflknnifngngslCASVGKILHPFQvsnn 284
                 42246666666.788888877775..559999*********7444444444444440.....0444444434444434444444444444444445444 PP

   Trypsin_2 113 .......sesaasgegesflqtdaatspGsSGGplf 141
                          +++  ++e++    + t  GsSGG  +
  EFC39034.1 285 diwekneEFQYDHSTQECLASSECLT-FGSSGGVMI 319
                 44333213333333333333555544.488888765 PP

>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.7   5.5e-05       0.5       6      22 ..     343     364 ..     338     400 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 5.5e-05
  Ephrin_rec_like   6 tgletCipCprgtYqn.....e 22 
                      +g ++C+ C r +Yq+     +
       EFC39034.1 343 GGFVRCSDCLREYYQSmkedgS 364
                      6889***********9764440 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (429 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       430  (0.0239835); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 2436.16
//
Query:       EFC39035.1  [L=2665]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-93  305.8 629.7     0.0001   22.6   7.4   36.0 36  EGF_2     EGF-like domain
    1.7e-05   25.1   0.2    6.3e-05   23.2   0.2    2.0  1  RGS       Regulator of G protein signaling domain
    0.00086   19.6  15.6     0.0011   19.2   6.3   36.7 37  EGF       EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   9.5   1.7e-07     0.001       6      32 .]      43      68 ..      38      68 .. 0.92
   2 !   20.7  10.0   6.5e-08   0.00039       6      32 .]      83     108 ..      78     108 .. 0.86
   3 !   20.7  10.9   6.4e-08   0.00038       5      32 .]     122     148 ..     118     148 .. 0.88
   4 !   19.5   7.6   1.6e-07   0.00097       5      32 .]     161     187 ..     156     187 .. 0.91
   5 !   21.8  11.6   2.9e-08   0.00017       6      32 .]     201     226 ..     197     226 .. 0.90
   6 !   22.6   7.4   1.7e-08    0.0001       5      32 .]     242     268 ..     238     268 .. 0.89
   7 !   18.0   9.5   4.7e-07    0.0028       4      32 .]     280     310 ..     278     310 .. 0.90
   8 !    8.5   4.8   0.00044       2.6       6      32 .]     324     350 ..     321     350 .. 0.92
   9 !   13.0   9.7   1.7e-05       0.1       1      32 []     355     385 ..     355     385 .. 0.92
  10 !   20.4   2.9   8.4e-08    0.0005       5      30 ..     399     423 ..     395     424 .. 0.88
  11 !   15.1  10.3   3.7e-06     0.022       1      31 [.     431     459 ..     431     459 .. 0.89
  12 !   13.8   8.9   9.8e-06     0.059       8      30 ..     472     493 ..     466     494 .. 0.86
  13 !   18.2  11.8   4.1e-07    0.0024       1      31 [.     501     529 ..     501     529 .. 0.87
  14 !   11.7   9.9   4.3e-05      0.25       8      30 ..     542     563 ..     536     564 .. 0.85
  15 !   15.6  11.2   2.5e-06     0.015       5      30 ..     574     598 ..     571     601 .. 0.84
  16 !   10.2  10.3   0.00013      0.77       6      30 ..     610     635 ..     601     636 .. 0.82
  17 !   17.7  11.0   5.6e-07    0.0034       1      30 [.     643     670 ..     643     673 .. 0.86
  18 !   16.2  13.3   1.6e-06    0.0098       6      32 .]     682     707 ..     673     707 .. 0.83
  19 !   13.5  11.4   1.2e-05      0.07       1      30 [.     712     739 ..     712     740 .. 0.89
  20 !   15.4  16.5     3e-06     0.018       6      32 .]     751     776 ..     742     776 .. 0.82
  21 !    9.5  13.4   0.00021       1.3       1      30 [.     781     808 ..     781     811 .. 0.86
  22 !   14.4  15.8   6.2e-06     0.037       5      32 .]     821     845 ..     816     845 .. 0.82
  23 !    8.4   9.3   0.00046       2.7       6      30 ..     854     877 ..     850     878 .. 0.81
  24 !   13.4  17.7   1.3e-05     0.076       6      32 .]     889     914 ..     885     914 .. 0.83
  25 !   14.3  11.1   6.5e-06     0.039       1      30 [.     919     946 ..     919     947 .. 0.86
  26 !    4.8  15.4    0.0064        38       6      32 .]     958     983 ..     949     983 .. 0.84
  27 !   12.5   6.8   2.4e-05      0.14       6      32 .]     997    1023 ..     994    1023 .. 0.88
  28 !   12.5   6.3   2.4e-05      0.15       7      32 .]    1038    1063 ..    1033    1063 .. 0.93
  29 !   18.2   8.2   4.1e-07    0.0024       5      32 .]    1076    1102 ..    1072    1102 .. 0.90
  30 !   19.7   7.3   1.3e-07   0.00081       5      32 .]    1117    1143 ..    1112    1143 .. 0.92
  31 !    7.2   8.2    0.0011       6.8       7      32 .]    1158    1182 ..    1153    1182 .. 0.90
  32 !    9.9  10.6   0.00016      0.97       4      32 .]    1193    1221 ..    1187    1221 .. 0.85
  33 !   11.2  10.8   6.1e-05      0.37       7      32 .]    1236    1261 ..    1230    1261 .. 0.90
  34 !   18.6  10.6   3.1e-07    0.0018       6      32 .]    1276    1301 ..    1272    1301 .. 0.93
  35 !   18.4   5.7   3.4e-07     0.002       7      32 .]    1316    1340 ..    1311    1340 .. 0.94
  36 ?   -3.8   0.2         3   1.8e+04      20      24 ..    2035    2039 ..    2031    2045 .. 0.69

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 1.7e-07
       EGF_2  6 eiCgghGtCvnqcGqCdCdsgyqGktC 32
                  C+g+G C +q  +C+Cd+ ++G +C
  EFC39035.1 43 QVCNGRGNCTEQD-NCECDPDWYGTQC 68
                57********999.7************ PP

  == domain 2  score: 20.7 bits;  conditional E-value: 6.5e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ghGtC  +   C+C+s+++G +C
  EFC39035.1  83 AVCNGHGTCSGTD-TCSCSSNWYGIDC 108
                 67*******9555.7************ PP

  == domain 3  score: 20.7 bits;  conditional E-value: 6.4e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C++++ +C+Cd+g++G +C
  EFC39035.1 122 NSVCKGNGDCIDTN-VCKCDDGWSGTQC 148
                 789*******8666.************* PP

  == domain 4  score: 19.5 bits;  conditional E-value: 1.6e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hG C ++   C C+++++G++C
  EFC39035.1 161 SNVCNSHGNCTDLD-TCNCKANWFGNDC 187
                 689*******9999.9************ PP

  == domain 5  score: 21.8 bits;  conditional E-value: 2.9e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+GtCv +++qC+C++gy+G++C
  EFC39035.1 201 TVCSGRGTCV-FTNQCQCPQGYTGNNC 226
                 67*******9.788************* PP

  == domain 6  score: 22.6 bits;  conditional E-value: 1.7e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + iC+ghG C+++   C+C+s y+G++C
  EFC39035.1 242 SVICSGHGNCIDTD-TCQCNSTYTGPKC 268
                 579*******8777.8************ PP

  == domain 7  score: 18.0 bits;  conditional E-value: 4.7e-07
       EGF_2   4 s.deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 +  ++C+g  +GtC +++  C+C++gy+G  C
  EFC39035.1 280 NtANACSGsvRGTCTSPN-TCSCNTGYTGSEC 310
                 55689**999*****999.9************ PP

  == domain 8  score: 8.5 bits;  conditional E-value: 0.00044
       EGF_2   6 eiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 + C + G C++++  C C  ++y+G +C
  EFC39035.1 324 NVCYNKGDCIAPN-SCNCtATNYTGLDC 350
                 57********999.7************9 PP

  == domain 9  score: 13.0 bits;  conditional E-value: 1.7e-05
       EGF_2   1 CsasdeiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 Cs+s ++C+  hG+C +++  C+C++ ++G +C
  EFC39035.1 355 CSPS-LQCWRrHGSCASETY-CSCNTDWTGISC 385
                 8885.88********99996.************ PP

  == domain 10  score: 20.4 bits;  conditional E-value: 8.4e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGk 30 
                  + C++hGtC +++  C+C +g+ G+
  EFC39035.1 399 ANVCSNHGTCTSAN-TCSCVTGWRGA 423
                 578*******9888.9********97 PP

  == domain 11  score: 15.1 bits;  conditional E-value: 3.7e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGkt 31 
                 C ++ ++C+ hG C+ ++ +C+C +g+ G+t
  EFC39035.1 431 CDSR-NYCSSHGDCIGPN-NCSCYAGWKGDT 459
                 7664.89********888.8*********96 PP

  == domain 12  score: 13.8 bits;  conditional E-value: 9.8e-06
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGk 30 
                 C ghG+C +++  C C+sg+ G+
  EFC39035.1 472 CYGHGICSSPN-TCTCNSGWRGA 493
                 ********999.9********98 PP

  == domain 13  score: 18.2 bits;  conditional E-value: 4.1e-07
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGkt 31 
                 C ++ ++C+ghG Cv ++  C+C++g+ G+t
  EFC39035.1 501 CDSR-NYCSGHGECVGAN-TCSCNDGWKGDT 529
                 7664.89********666.9*********96 PP

  == domain 14  score: 11.7 bits;  conditional E-value: 4.3e-05
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGk 30 
                 C ghG+C  ++  C C+sg+ G+
  EFC39035.1 542 CYGHGICSGPN-TCTCNSGWRGA 563
                 ********888.9********98 PP

  == domain 15  score: 15.6 bits;  conditional E-value: 2.5e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGk 30 
                  ++C+ghGtC  ++  C C+sg+ G+
  EFC39035.1 574 TNYCSGHGTCTGAN-TCTCESGWKGN 598
                 589********666.9********96 PP

  == domain 16  score: 10.2 bits;  conditional E-value: 0.00013
       EGF_2   6 eiCgg..hGtCvnqcGqCdCdsgyqGk 30 
                 ++Cgg   GtCv+ +  C+C++g+ G+
  EFC39035.1 610 SNCGGasKGTCVSNN-TCSCKTGWRGA 635
                 67*********9555.9*******996 PP

  == domain 17  score: 17.7 bits;  conditional E-value: 5.6e-07
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C ++ ++C+ghGtC  ++  C Cdsg+ G+
  EFC39035.1 643 CDQR-NYCSGHGTCTGAN-TCTCDSGWKGN 670
                 7665.89********666.9********96 PP

  == domain 18  score: 16.2 bits;  conditional E-value: 1.6e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  +C+ghGtC++ +  C C+sg++ ++C
  EFC39035.1 682 GACNGHGTCISNN-TCNCNSGWTEANC 707
                 57*******9555.9********9999 PP

  == domain 19  score: 13.5 bits;  conditional E-value: 1.2e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C+++ ++C+ghGtC  ++  C C sg+ G+
  EFC39035.1 712 CKDR-DFCSGHGTCTGAN-TCNCVSGWKGN 739
                 9986.8*********666.9********97 PP

  == domain 20  score: 15.4 bits;  conditional E-value: 3e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+++G+C+  +  C+C sg++G++C
  EFC39035.1 751 NSCSQNGQCIGNN-TCECRSGWTGASC 776
                 67********334.7************ PP

  == domain 21  score: 9.5 bits;  conditional E-value: 0.00021
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C as ++C+ +G C++ +  C+C sg+ G+
  EFC39035.1 781 CDAS-SNCNSNGLCISNN-TCQCYSGWKGN 808
                 8885.88*******9555.9********96 PP

  == domain 22  score: 14.4 bits;  conditional E-value: 6.2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+++G+C+  +  C+C sg++G++C
  EFC39035.1 821 G--CSQNGVCIGNN-TCQCRSGWSGPKC 845
                 3..********334.7************ PP

  == domain 23  score: 8.4 bits;  conditional E-value: 0.00046
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C  hG C++ +  C+C+sg+ G 
  EFC39035.1 854 LNCYDHGLCISNN-TCQCQSGWKGS 877
                 56*******9555.9********96 PP

  == domain 24  score: 13.4 bits;  conditional E-value: 1.3e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+++G+C+  +  C+C sg++G +C
  EFC39035.1 889 NSCSQNGQCIGNN-TCQCRSGWTGSNC 914
                 67********334.7************ PP

  == domain 25  score: 14.3 bits;  conditional E-value: 6.5e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C as ++C+g+G C++ +  C+C++g+ G+
  EFC39035.1 919 CDAS-DNCHGNGLCISNN-TCQCNTGWKGN 946
                 8885.78*******9555.9********96 PP

  == domain 26  score: 4.8 bits;  conditional E-value: 0.0064
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  +C+ +G C  ++  C C s+y+G  C
  EFC39035.1 958 AYCSSQGNCTGAN-LCNCTSQYTGSRC 983
                 68********666.8***********9 PP

  == domain 27  score: 12.5 bits;  conditional E-value: 2.4e-05
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyq.GktC 32  
                  + C+++G+Cv++   C+C sg++ G +C
  EFC39035.1  997 NVCSNNGSCVAPD-TCQCLSGFSsGGQC 1023
                  57********999.9*******977666 PP

  == domain 28  score: 12.5 bits;  conditional E-value: 2.4e-05
       EGF_2    7 iCgghGtCvnqcGqCdC.dsgyqGktC 32  
                  +C+  G+C ++  +C+C d +y+Gk+C
  EFC39035.1 1038 QCNAKGICTSPD-VCYCtDYNYYGKNC 1063
                  6********999.************** PP

  == domain 29  score: 18.2 bits;  conditional E-value: 4.1e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g G+C+ ++ +C+C+ gy+G++C
  EFC39035.1 1076 NTVCSGFGKCILPN-NCSCNLGYSGNNC 1102
                  678*******9666.8************ PP

  == domain 30  score: 19.7 bits;  conditional E-value: 1.3e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + iC+g G+C+++  +C+C +gy+G++C
  EFC39035.1 1117 KFICSGKGSCISPD-KCSCVTGYTGDKC 1143
                  789********999.************* PP

  == domain 31  score: 7.2 bits;  conditional E-value: 0.0011
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g G+C+++   C+C  gy G +C
  EFC39035.1 1158 VCSGFGQCIDTD-LCSCGYGYGGSNC 1182
                  7*******8777.9**********99 PP

  == domain 32  score: 9.9 bits;  conditional E-value: 0.00016
       EGF_2    4 s.deiCgghGtCvnqcGq..CdCdsgyqGktC 32  
                  + ++ C+++G+C+   G+  C C s y+G++C
  EFC39035.1 1193 NsSNVCNQRGSCI---GVdfCNCTSTYSGNNC 1221
                  35899********...5667************ PP

  == domain 33  score: 11.2 bits;  conditional E-value: 6.1e-05
       EGF_2    7 iCgghGtCvnqcGqCdC.dsgyqGktC 32  
                   C+g G+C++++  C+C  +gy+G  C
  EFC39035.1 1236 VCNGKGQCNSEN-TCSCqVQGYFGEEC 1261
                  6********777.9***99*******9 PP

  == domain 34  score: 18.6 bits;  conditional E-value: 3.1e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ghG+C +++ +C+C +g++G +C
  EFC39035.1 1276 NVCSGHGQCKSPN-NCECTNGFTGENC 1301
                  57********999.8***********9 PP

  == domain 35  score: 18.4 bits;  conditional E-value: 3.4e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+++G+C++++  C+C+  ++Gk+C
  EFC39035.1 1316 VCSQNGICNSPN-TCECSYPWFGKNC 1340
                  7********999.9************ PP

  == domain 36  score: -3.8 bits;  conditional E-value: 3
       EGF_2   20 qCdCd 24  
                  +C+Cd
  EFC39035.1 2035 VCKCD 2039
                  59995 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.2   1.1e-08   6.3e-05       2      75 ..    2450    2532 ..    2449    2558 .. 0.89

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 1.1e-08
                  HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.....SHHHHHHHH....HHHHHHHHTSTTSTTSSTS-HHHHHH CS
         RGS    2 leslledqpgrslFreFlesefseenlsFwlaveefkka.....keqeelkkk....akeIyneylapsspkelnidkklree 75  
                  l+++++d+ g  lF+eF+++e s enl  + +++ f  +     +++ee++k+    + + y+ y++ +++ e+ni+++ r++
  EFC39035.1 2450 LSQVMSDSEGIILFEEFCKKEWSLENLYMYVDIKLFMDTlenkmDDSEEFLKHlysyCVSTYEVYIKLGATMEVNIPSHSRNS 2532
                  7899***********************************999996666666665666999********************997 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   4.5      0.11   6.6e+02       5      30 ..      41      65 ..      38      67 .. 0.81
   2 !    9.8   4.5   0.00016      0.97       6      31 ..      85     106 ..      78     107 .. 0.87
   3 !    6.4   4.1    0.0019        11       5      30 ..     122     145 ..     118     147 .. 0.87
   4 !    6.1   3.9    0.0024        14       3      31 ..     161     185 ..     159     186 .. 0.89
   5 !   19.2   6.3   1.9e-07    0.0011       3      32 .]     199     225 ..     196     225 .. 0.86
   6 !    6.5   4.0    0.0018        11       6      31 ..     245     266 ..     239     267 .. 0.92
   7 !    4.2   3.7    0.0094        56       9      31 ..     290     308 ..     281     309 .. 0.86
   8 ?    0.6   4.1      0.12   7.2e+02       3      30 ..     323     347 ..     320     349 .. 0.87
   9 ?    0.4   1.0      0.14   8.4e+02       9      31 ..     365     383 ..     363     384 .. 0.85
  10 !   11.1   5.7   6.4e-05      0.38       5      30 ..     400     422 ..     390     423 .. 0.79
  11 ?    1.7   9.5     0.057   3.4e+02       1      32 []     431     459 ..     431     459 .. 0.85
  12 ?    2.7   8.5     0.027   1.6e+02       1      31 [.     466     493 ..     466     494 .. 0.80
  13 !    5.8   9.4    0.0028        17       1      32 []     501     529 ..     501     529 .. 0.88
  14 ?    1.8   9.8     0.053   3.2e+02       1      31 [.     536     563 ..     536     564 .. 0.84
  15 !    6.2  12.3    0.0021        13       1      31 [.     571     598 ..     571     599 .. 0.89
  16 !    5.9   0.8    0.0027        16      10      31 ..     618     635 ..     616     636 .. 0.90
  17 !    9.2  11.1   0.00025       1.5       1      31 [.     643     670 ..     643     671 .. 0.90
  18 !    7.6   8.5   0.00082       4.9       1      31 [.     678     705 ..     678     706 .. 0.90
  19 !    7.0   9.3    0.0013       7.5       1      31 [.     712     739 ..     712     740 .. 0.91
  20 ?    3.9   8.5     0.011        68       1      31 [.     747     774 ..     747     775 .. 0.83
  21 !    8.1   7.2   0.00055       3.3       1      31 [.     781     808 ..     781     809 .. 0.88
  22 ?    0.6  10.1      0.12   7.4e+02       5      31 ..     821     843 ..     811     844 .. 0.81
  23 !    7.6   6.8   0.00082       4.9       1      31 [.     850     877 ..     850     878 .. 0.88
  24 ?    3.7   9.9     0.013        77       1      32 []     885     913 ..     885     913 .. 0.83
  25 !    8.3   9.3   0.00048       2.9       1      31 [.     919     946 ..     919     947 .. 0.91
  26 ?   -6.7   9.8         3   1.8e+04       6      32 .]     960     982 ..     949     982 .. 0.74
  27 !   16.4   1.8   1.4e-06    0.0084       3      29 ..     996    1018 ..     993    1019 .. 0.89
  28 ?   -4.4   3.5         3   1.8e+04       4      25 ..    1035    1054 ..    1033    1062 .. 0.71
  29 !    8.0   5.6   0.00061       3.6       4      32 .]    1076    1101 ..    1073    1101 .. 0.89
  30 !    7.5   5.9   0.00083         5       6      31 ..    1120    1141 ..    1107    1142 .. 0.85
  31 !    5.7   4.8    0.0032        19       4      32 .]    1155    1181 ..    1152    1181 .. 0.89
  32 ?   -2.2   5.5      0.94   5.6e+03       3      32 .]    1195    1220 ..    1193    1220 .. 0.80
  33 ?    3.0   5.4     0.022   1.3e+02       4      31 ..    1233    1259 ..    1230    1260 .. 0.85
  34 !    9.9   7.5   0.00015      0.89       5      32 .]    1276    1300 ..    1272    1300 .. 0.87
  35 ?    3.7   2.8     0.013        77       6      32 .]    1317    1339 ..    1312    1339 .. 0.81
  36 ?   -0.6   0.3      0.29   1.8e+03       6      12 ..    1504    1509 ..    1502    1517 .. 0.77
  37 ?   -1.6   0.7      0.61   3.7e+03       9      25 ..    2022    2039 ..    2020    2040 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.11
                T...STTT-EEEEETTTEEEEEECTTEES CS
         EGF  5 p...CsngGtCvdtgrggytCiCpeGytG 30
                +   C+++G C     +  +C+C++ + G
  EFC39035.1 41 TtqvCNGRGNC----TEQDNCECDPDWYG 65
                3457*******....6678******9988 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00016
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+++GtC    +g+ tC C++ + G+
  EFC39035.1  85 CNGHGTC----SGTDTCSCSSNWYGI 106
                 *******....7***********996 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0019
                 T..STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p..CsngGtCvdtgrggytCiCpeGytG 30 
                 +  C+++G C+dt      C+C+ G++G
  EFC39035.1 122 NsvCKGNGDCIDTN----VCKCDDGWSG 145
                 567**********9....*********9 PP

  == domain 4  score: 6.1 bits;  conditional E-value: 0.0024
                 STTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   3 pnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 +n C+ +G C d+     tC C+  ++G+
  EFC39035.1 161 SNVCNSHGNCTDLD----TCNCKANWFGN 185
                 466*******9999....*********97 PP

  == domain 5  score: 19.2 bits;  conditional E-value: 1.9e-07
                 STT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   3 pnp.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 +++ Cs++GtCv t     +C+Cp+GytG++
  EFC39035.1 199 DTTvCSGRGTCVFTN----QCQCPQGYTGNN 225
                 4458*******8888....8*********86 PP

  == domain 6  score: 6.5 bits;  conditional E-value: 0.0018
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C+dt     tC+C + ytG+
  EFC39035.1 245 CSGHGNCIDTD----TCQCNSTYTGP 266
                 ***********....*****999996 PP

  == domain 7  score: 4.2 bits;  conditional E-value: 0.0094
                 T-EEEEETTTEEEEEECTTEEST CS
         EGF   9 gGtCvdtgrggytCiCpeGytGk 31 
                 +GtC ++     tC C +GytG+
  EFC39035.1 290 RGTCTSPN----TCSCNTGYTGS 308
                 68896666....9*********6 PP

  == domain 8  score: 0.6 bits;  conditional E-value: 0.12
                 STTSTTT-EEEEETTTEEEEEEC.TTEES CS
         EGF   3 pnpCsngGtCvdtgrggytCiCp.eGytG 30 
                 pn C n G C+ +     +C C+ + ytG
  EFC39035.1 323 PNVCYNKGDCIAPN----SCNCTaTNYTG 347
                 566*********99....*****999999 PP

  == domain 9  score: 0.4 bits;  conditional E-value: 0.14
                 T-EEEEETTTEEEEEECTTEEST CS
         EGF   9 gGtCvdtgrggytCiCpeGytGk 31 
                 +G C      + +C C + +tG+
  EFC39035.1 365 HGSC----ASETYCSCNTDWTGI 383
                 5678....68899********96 PP

  == domain 10  score: 11.1 bits;  conditional E-value: 6.4e-05
                 T.STTT-EEEEETTTEEEEEECTTEES CS
         EGF   5 p.CsngGtCvdtgrggytCiCpeGytG 30 
                 + Csn+GtC        tC C +G+ G
  EFC39035.1 400 NvCSNHGTC----TSANTCSCVTGWRG 422
                 36*******....5566********99 PP

  == domain 11  score: 1.7 bits;  conditional E-value: 0.057
                 GCSTT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 C++ + Cs +G C     g  +C C  G++G++
  EFC39035.1 431 CDSRNyCSSHGDC----IGPNNCSCYAGWKGDT 459
                 999555*******....4666**********85 PP

  == domain 12  score: 2.7 bits;  conditional E-value: 0.027
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   + C ++G+C ++     tC+C +G+ G+
  EFC39035.1 466 CELvGGCYGHGICSSP----NTCTCNSGWRGA 493
                 565456*******444....5********995 PP

  == domain 13  score: 5.8 bits;  conditional E-value: 0.0028
                 GCSTT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 C++ + Cs++G+C     g  tC C  G++G++
  EFC39035.1 501 CDSRNyCSGHGEC---V-GANTCSCNDGWKGDT 529
                 999555*******...6.788**********85 PP

  == domain 14  score: 1.8 bits;  conditional E-value: 0.053
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C   + C ++G+C    +g  tC+C +G+ G+
  EFC39035.1 536 CELvGGCYGHGIC----SGPNTCTCNSGWRGA 563
                 565456*******....6899********995 PP

  == domain 15  score: 6.2 bits;  conditional E-value: 0.0021
                 GCSTT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+ ++ Cs++GtC     g  tC+C +G++G+
  EFC39035.1 571 CDGTNyCSGHGTC----TGANTCTCESGWKGN 598
                 777666*******....88***********96 PP

  == domain 16  score: 5.9 bits;  conditional E-value: 0.0027
                 -EEEEETTTEEEEEECTTEEST CS
         EGF  10 GtCvdtgrggytCiCpeGytGk 31 
                 GtCv++     tC C++G+ G+
  EFC39035.1 618 GTCVSNN----TCSCKTGWRGA 635
                 8999999....********995 PP

  == domain 17  score: 9.2 bits;  conditional E-value: 0.00025
                 GCSTT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 C++ + Cs++GtC     g  tC+C++G++G+
  EFC39035.1 643 CDQRNyCSGHGTC----TGANTCTCDSGWKGN 670
                 999555*******....88***********96 PP

  == domain 18  score: 7.6 bits;  conditional E-value: 0.00082
                 GCSTT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+    C+++GtC+++     tC C +G+t +
  EFC39035.1 678 CDALGaCNGHGTCISNN----TCNCNSGWTEA 705
                 888777*******9999....********976 PP

  == domain 19  score: 7.0 bits;  conditional E-value: 0.0013
                 GCSTT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 C++   Cs++GtC     g  tC C +G++G+
  EFC39035.1 712 CKDRDfCSGHGTC----TGANTCNCVSGWKGN 739
                 888779*******....88***********97 PP

  == domain 20  score: 3.9 bits;  conditional E-value: 0.011
                 GCSTT.STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  + Cs +G C     g  tC+C +G+tG+
  EFC39035.1 747 CDGVNsCSQNGQC----IGNNTCECRSGWTGA 774
                 666455*******....5788*********96 PP

  == domain 21  score: 8.1 bits;  conditional E-value: 0.00055
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+   +C+ +G C+++     tC+C +G++G+
  EFC39035.1 781 CDAsSNCNSNGLCISNN----TCQCYSGWKGN 808
                 555579*******9999....*********96 PP

  == domain 22  score: 0.6 bits;  conditional E-value: 0.12
                 TSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   5 pCsngGtCvdtgrggytCiCpeGytGk 31 
                  Cs +G C     g  tC+C +G++G+
  EFC39035.1 821 GCSQNGVC----IGNNTCQCRSGWSGP 843
                 499999**....5777*********97 PP

  == domain 23  score: 7.6 bits;  conditional E-value: 0.00082
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+   +C  +G C+++     tC+C++G++G+
  EFC39035.1 850 CDGvLNCYDHGLCISNN----TCQCQSGWKGS 877
                 555578*******9999....*********96 PP

  == domain 24  score: 3.7 bits;  conditional E-value: 0.013
                 GCSTT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGytGkr 32 
                 C+  + Cs +G C     g  tC+C +G+tG++
  EFC39035.1 885 CDGVNsCSQNGQC----IGNNTCQCRSGWTGSN 913
                 666455*******....5788**********86 PP

  == domain 25  score: 8.3 bits;  conditional E-value: 0.00048
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  ++C+++G C+++     tC+C +G++G+
  EFC39035.1 919 CDAsDNCHGNGLCISNN----TCQCNTGWKGN 946
                 666699*******9999....*********96 PP

  == domain 26  score: -6.7 bits;  conditional E-value: 3
                 STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGkr 32 
                 Cs +G C     g   C C++ ytG+r
  EFC39035.1 960 CSSQGNC----TGANLCNCTSQYTGSR 982
                 7777777....77888*********86 PP

  == domain 27  score: 16.4 bits;  conditional E-value: 1.4e-06
                  STTSTTT-EEEEETTTEEEEEECTTEE CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGyt 29  
                  pn Csn+G Cv +     tC+C +G++
  EFC39035.1  996 PNVCSNNGSCVAPD----TCQCLSGFS 1018
                  455***********....*******96 PP

  == domain 28  score: -4.4 bits;  conditional E-value: 3
                  TT..STTT-EEEEETTTEEEEEEC CS
         EGF    4 np..CsngGtCvdtgrggytCiCp 25  
                  +p  C+  G+C ++      C C+
  EFC39035.1 1035 DPtqCNAKGICTSPD----VCYCT 1054
                  45569999***6666....88886 PP

  == domain 29  score: 8.0 bits;  conditional E-value: 0.00061
                  TT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    4 np.CsngGtCvdtgrggytCiCpeGytGkr 32  
                  n+ Cs+ G+C+ +     +C C  Gy+G++
  EFC39035.1 1076 NTvCSGFGKCILPN----NCSCNLGYSGNN 1101
                  449*******9999....9*********86 PP

  == domain 30  score: 7.5 bits;  conditional E-value: 0.00083
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs+ G C+++     +C C +GytG+
  EFC39035.1 1120 CSGKGSCISPD----KCSCVTGYTGD 1141
                  ***********....**********7 PP

  == domain 31  score: 5.7 bits;  conditional E-value: 0.0032
                  TT..STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    4 np..CsngGtCvdtgrggytCiCpeGytGkr 32  
                   p  Cs+ G C+dt      C C  Gy G++
  EFC39035.1 1155 MPsvCSGFGQCIDTD----LCSCGYGYGGSN 1181
                  6788***********....********9975 PP

  == domain 32  score: -2.2 bits;  conditional E-value: 0.94
                  STTSTTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    3 pnpCsngGtCvdtgrggytCiCpeGytGkr 32  
                  +n C+ +G C+ +      C C++ y+G++
  EFC39035.1 1195 SNVCNQRGSCIGVD----FCNCTSTYSGNN 1220
                  466*******5555....9***99999985 PP

  == domain 33  score: 3.0 bits;  conditional E-value: 0.022
                  TT..STTT-EEEEETTTEEEEEEC.TTEEST CS
         EGF    4 np..CsngGtCvdtgrggytCiCp.eGytGk 31  
                  +p  C++ G C    + + tC C+ +Gy+G+
  EFC39035.1 1233 DPqvCNGKGQC----NSENTCSCQvQGYFGE 1259
                  6778*******....6667**********97 PP

  == domain 34  score: 9.9 bits;  conditional E-value: 0.00015
                  T.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    5 p.CsngGtCvdtgrggytCiCpeGytGkr 32  
                  + Cs++G C ++     +C+C++G+tG++
  EFC39035.1 1276 NvCSGHGQCKSPN----NCECTNGFTGEN 1300
                  45*******8888....**********96 PP

  == domain 35  score: 3.7 bits;  conditional E-value: 0.013
                  STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGkr 32  
                  Cs +G+C ++     tC+C+ +++Gk+
  EFC39035.1 1317 CSQNGICNSPN----TCECSYPWFGKN 1339
                  *******5555....*****9999986 PP

  == domain 36  score: -0.6 bits;  conditional E-value: 0.29
                  STTT-EE CS
         EGF    6 CsngGtC 12  
                  C+ngG C
  EFC39035.1 1504 CNNGG-C 1509
                  *****.9 PP

  == domain 37  score: -1.6 bits;  conditional E-value: 0.61
                  T-EE.EEET.TTEEEEEEC CS
         EGF    9 gGtC.vdtg.rggytCiCp 25  
                  +G C v++  +g+  C+C+
  EFC39035.1 2022 NG-CyVSSFvNGDVVCKCD 2039
                  45.8555558999*****7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1325  (0.0739026); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.27u 0.30s 00:00:01.57 Elapsed: 00:00:00.55
# Mc/sec: 14566.54
//
Query:       EFC39036.1  [L=820]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.19   11.7   0.1       0.48   10.4   0.1    1.6  1  Arm_vescicular  Armadillo tether-repeat of vescicular transpo
       0.66   10.4   4.2       0.45   11.0   0.1    2.7  3  CelTOS          Cell-traversal protein for ookinetes and spor
          2    9.3   4.7        1.6    9.6   0.1    3.1  4  Csm2_III-A      Csm2 Type III-A


Domain annotation for each model (and alignments):
>> Arm_vescicular  Armadillo tether-repeat of vescicular transport factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.1   8.1e-05      0.48      13      41 ..     363     391 ..     358     397 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 8.1e-05
  Arm_vescicular  13 hlmLqvvRaLVspsnpsqvvrsCqkamrk 41 
                     +l+++ +RaL spsn++ + + C++++++
      EFC39036.1 363 ELVIDCLRALSSPSNNQRNFSRCKNVVQA 391
                     5678889******************9975 PP

>> CelTOS  Cell-traversal protein for ookinetes and sporozoites
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1       0.4   2.4e+03      16      46 ..     326     359 ..     314     398 .. 0.72
   2 ?   11.0   0.1   7.5e-05      0.45      10      59 ..     502     550 ..     497     570 .. 0.81
   3 ?   -2.6   0.1       1.2   7.4e+03      27      49 ..     739     756 ..     717     778 .. 0.53

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.4
      CelTOS  16 klseiir..adldskgd.elvdliandlekelqk 46 
                 ++++ii+  + +d+ gd ++v+ i++ l + l+ 
  EFC39036.1 326 RVRKIISimEIIDQRGDnNIVESISSFLTRLLKY 359
                 5555554226678887635889998888887764 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 7.5e-05
      CelTOS  10 qkslssklseiiradldskgdelvdliandlekelqknslvaasfLqsgf 59 
                  ++l+  l ei+r  +dsk  e+vd++ + l+++l + +l++++f + g+
  EFC39036.1 502 SETLVRPLDEIVRGAIDSKSLEVVDIVQK-LVESLLNTELTKLVFKNLGN 550
                 567888999****************7665.66666777789999977664 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.2
      CelTOS  27 skgdelvdliandlekelqknsl 49 
                 ++ d + d i+ +  ++     l
  EFC39036.1 739 DIFDAITDCISFNESRS-----L 756
                 33333333333322222.....2 PP

>> Csm2_III-A  Csm2 Type III-A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.1   0.00026       1.6      37      92 ..      41      97 ..      34     110 .. 0.84
   2 ?   -1.3   0.0      0.63   3.8e+03      21      73 ..     206     259 ..     199     302 .. 0.63
   3 ?   -1.6   0.1      0.77   4.6e+03      85      85 ..     357     357 ..     279     393 .. 0.55
   4 ?   -2.2   0.2       1.2   7.2e+03      56     105 ..     440     488 ..     423     492 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00026
                HHHHHHHHTHHHHHHHTHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHH--SH. CS
  Csm2_III-A 37 rieekikkkkeeeseeilrklkllkpklaYaag.reeavkelsevlkkaidkvkksk 92
                +i++k + + + +see+l++lk ++ +++++a+ r+e  k+l++ l ++ ++v++ k
  EFC39036.1 41 DINQKAEAWPTYTSEELLQHLKEMRNRVINQASyRKEPCKTLVQNLIEMYKTVSNGK 97
                56666666666669****************987478****************99974 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.63
                 TTS-STTTHHHHHHHHHHHHHHHHTHHHH.HHHTHHHHHHHHHHHHHHHHHHHH CS
  Csm2_III-A  21 kklktsqiRkfydevkrieekikkkkeee.seeilrklkllkpklaYaagreea 73 
                   + + q+  f++++k++   + + ++ e s   ++++  +   l+Y+++ e +
  EFC39036.1 206 AGVPSLQVKYFLKHFKSLIVTYYNASNWEgSYIDMNDMDCILLDLIYKSKDEDQ 259
                 456777888888888888888777777776666677777777888887776433 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.77
                 H CS
  Csm2_III-A  85 i 85 
                 +
  EFC39036.1 357 L 357
                 1 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 1.2
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH--SH.HHHHHHHHHHHHH CS
  Csm2_III-A  56 klkllkpklaYaagreeavkelsevlkkaidkvkkskekfkrfvdffEAi 105
                 k+++lk+  a  + +      +se+  ++i+kv +  ++ + f+++ ++i
  EFC39036.1 440 KVNYLKIFTAAFKYC-CTESIFSEKALEVIQKVAECMKEQDYFLQVADSI 488
                 566666544433333.1223366666666666665555555555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (820 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1076  (0.0600145); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 4627.93
//
Query:       EFC39037.1  [L=126]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      5e-06   26.5  89.4    1.8e+04  -26.9  89.4    3.0  1  Trypan_PARP  Procyclic acidic repetitive protein (PARP)


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -26.9  89.4         1   1.8e+04      58     101 ..      62     105 ..       1     124 [. 0.54

  Alignments for each domain:
  == domain 1  score: -26.9 bits;  conditional E-value: 1
  Trypan_PARP  58 dpepepepepepepepepepepetepeeepepepepepepepep 101
                  +p+p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p
   EFC39037.1  62 KPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNPNP 105
                  11112222222222222222222222222222222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       365  (0.0203581); expected 358.6 (0.02)
Passed bias filter:                      101  (0.00563333); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 739.22
//
Query:       EFC39038.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.029   14.1   0.0      0.059   13.2   0.0    1.4  1  Bac_A_amyl_C  Bacterial Alpha amylase C-terminal domain
       0.17   12.3  12.6       0.37   11.2  12.6    1.5  1  PRP1_N        PRP1 splicing factor, N-terminal
       0.88    9.0   4.5        1.3    8.4   4.5    1.2  1  PMSI1         Protein missing in infertile sperm 1, putative
          1    8.1   6.2        1.1    8.0   6.2    1.2  1  Presenilin    Presenilin
        1.2    8.6   9.7          2    7.8   9.7    1.3  1  PIEZO         Piezo
          2    8.0   9.5      0.074   12.7   3.1    1.7  2  CAC1F_C       Voltage-gated calcium channel subunit alpha, C-
        2.1    6.8  16.6          2    6.9  12.6    2.0  2  LRIF1         Ligand-dependent nuclear receptor-interacting f


Domain annotation for each model (and alignments):
>> Bac_A_amyl_C  Bacterial Alpha amylase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   2.3e-05     0.059      14      54 ..     120     160 ..     117     161 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.3e-05
                   EEEETTEEEEEEE-TT--EEEEE--S-SEEEEETTTSEEEE CS
  Bac_A_amyl_C  14 tYelkekklvGiFsLkgkegevkvdlpDGsYkNlidgseve 54 
                   +Y +k++ l+ + +L+  +  v+ +++D+sYkN+ ++ +v+
    EFC39038.1 120 KYNKKQSFLFPLLPLQTAKVIVEKQVKDNSYKNIFQDVSVT 160
                   799*******************************9987775 PP

>> PRP1_N  PRP1 splicing factor, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2  12.6   0.00014      0.37      17     105 ..       9      96 ..       4     108 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00014
                 --............................---------.----------.--------------------HHHHHHHHHHHHHHTT---- CS
      PRP1_N  17 ttrsdigpareaeaseeekkkkkeeeeeeeedeedlqde.endefegese.glfakaeydedDeeAdriyeeiderlderrkkrreakeke 105
                 t +sd+ + +++ a++ee   + +ee+++e +++ ++++  + +f++  + +l a  ++de+Dee +++ye++ e+ +e+++++ +   ++
  EFC39038.1   9 TAQSDVHQKKKKVANDEE---NVDEESHHETSKNYIESKlFKSSFSEGGSfKLSAAFNEDEEDEEEEEMYEQLSEQQQEQQQSESTMIDRT 96 
                 456777775553333222...222233344444444444344555555555777777******************9999988876655544 PP

>> PMSI1  Protein missing in infertile sperm 1, putative
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   4.5   0.00051       1.3      25     118 ..       7     102 ..       2     127 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00051
       PMSI1  25 rstartdlprktrvtledeeDavaeadrLagPa..aaeLLastvatgisksklsqieedgsleegvvinarkndtesesestssstagssssrfaa 118
                 + ta++d+ +k + + +dee++  e+ +  +       L  s+ + g s + +++++ed++ ee+  ++ + +++++e+++++s+   ++ss+ + 
  EFC39038.1   7 NDTAQSDVHQKKKKVANDEENVDEESHHETSKNyiESKLFKSSFSEGGSFKLSAAFNEDEEDEEEEEMYEQLSEQQQEQQQSESTMIDRTSSHNIR 102
                 678999999999999999999888887766655115669999999998888788889999999999999999998888888777777777765444 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   6.2   0.00042       1.1     239     298 ..       9      90 ..       1     174 [. 0.57

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00042
  Presenilin 239 eeaekkkeeasesskeeeseeesseksaqsse..........................seeeseeesseaessaeesseekesees 298
                 +++++ ++++++  ++ee+ +e+s++++++ +                          +   ++ee++e+ ++ +e+++e++++es
  EFC39038.1   9 TAQSDVHQKKKKVANDEENVDEESHHETSK-NyiesklfkssfseggsfklsaafnedE---EDEEEEEMYEQLSEQQQEQQQSES 90 
                 222222222222222222222222222221.1244556666666666666666664321...222222222222222222211111 PP

>> PIEZO  Piezo
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   9.7   0.00078         2     130     216 ..       6      99 ..       2     108 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00078
       PIEZO 130 kkgkkeseeeelakeeeeeeeeaeeekkksekkkwwrPwvdhasvvrsgdYyl...Fesdseeeeeeee....keeeepkkksafqlayeawvt 216
                 k+ +++s+ ++++k+ +++ee+ +ee++++++k++++  + ++s  + g++ l   F+ d+e+eeeee     +e+++ +++s   ++ ++  +
  EFC39038.1   6 KNDTAQSDVHQKKKKVANDEENVDEESHHETSKNYIESKLFKSSFSEGGSFKLsaaFNEDEEDEEEEEMyeqlSEQQQEQQQSESTMIDRTSSH 99 
                 33444455555444445557778888888999*******************9977799999888887766666666666666666666555555 PP

>> CAC1F_C  Voltage-gated calcium channel subunit alpha, C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.4      0.43   1.1e+03     127     140 ..      20      33 ..       2      57 .. 0.42
   2 ?   12.7   3.1   2.9e-05     0.074      15     132 ..      60     177 ..      54     218 .. 0.54

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.43
     CAC1F_C 127 ekglekqeeeeeev 140
                 + + ++++++ee+ 
  EFC39038.1  20 KVANDEENVDEESH 33 
                 11222222222221 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 2.9e-05
     CAC1F_C  15 lAlaedleeeeeeaeleeeeedleasaapkaelesqpesrrssavsvsltveeelpdslsapsddrgvsskis...srkpsvkqslssetkrsskvevl 110
                  A++ed e+eeee++ e+ +e+++++++++ +++ + +s ++ +    +   ++lp+   + s++ +++++        +++k  + ++ k +s+++++
  EFC39038.1  60 AAFNEDEEDEEEEEMYEQLSEQQQEQQQSE-STMIDRTSSHNIR---ICKDPSSLPTPNWNLSSKYNKKQSFLfplLPLQTAKVIVEKQVKDNSYKNIF 154
                 689999999999999888888777775553.3333333333322...2334556666555555554444443322222233344444666666677777 PP

     CAC1F_C 111 tedsegsaklkae.vsgekglek 132
                 +  s+ s  +++    g  g+  
  EFC39038.1 155 QDVSVTSIIQNNFrDFGMYGQTF 177
                 76666666555334455555544 PP

>> LRIF1  Ligand-dependent nuclear receptor-interacting factor 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9  12.6   0.00078         2     606     702 ..       3     100 ..       1     119 [. 0.74
   2 ?    1.9   0.1     0.025        63     212     247 ..     133     169 ..     120     189 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00078
       LRIF1 606 kKRkaktsklvdsaKrrktsnksstssnsetsspssqllssslsksavslqasistdsskssqekksEee.llsqesdeketlssvlvsseedeslfe 702
                  KRk  t++   + K++k  n+++++ ++ ++ +s + ++s+l ks  s   s + + +  + e++ Eee ++ q s+++++++   +++ + +s ++
  EFC39038.1   3 PKRKNDTAQSDVHQKKKKVANDEENVDEESHHETSKNYIESKLFKSSFSEGGSFKLSAAFNEDEEDEEEEeMYEQLSEQQQEQQQSESTMIDRTSSHN 100
                 59**************************99999999*************9999888877776666655541444444433333333555666555555 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.025
       LRIF1 212 PVNtVKtvvtKklqaispKp.atevsktliltasqta 247
                 P  t K +v+K+++  s K    +vs t i++ + ++
  EFC39038.1 133 PLQTAKVIVEKQVKDNSYKNiFQDVSVTSIIQNNFRD 169
                 999****************9999*****999876555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2420  (0.134977); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 1318.51
//
Query:       EFC39039.1  [L=214]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.2e-27   93.2   1.8    1.2e-26   92.5   1.8    1.4  1  dCMP_cyt_deam_1  Cytidine and deoxycytidylate deaminase zinc-
    3.2e-26   91.7   2.3    7.8e-26   90.5   2.3    1.7  1  MafB19-deam      MafB19-like deaminase
    2.3e-05   24.5   0.5    5.9e-05   23.2   0.1    1.8  2  SNAD4            Secreted Novel AID/APOBEC-like Deaminase 4
    0.00075   19.6   0.1     0.0013   18.8   0.1    1.4  1  APOBEC2          APOBEC2
    0.00083   19.5   0.2     0.0016   18.6   0.2    1.4  1  APOBEC3          APOBEC3
     0.0015   18.4   0.2     0.0032   17.3   0.2    1.5  1  Inv-AAD          Invertebrate-AID/APOBEC-deaminase
     0.0024   18.0   0.5     0.0038   17.3   0.1    1.6  2  NAD1             Novel AID APOBEC clade 1
      0.005   16.8   0.1      0.011   15.7   0.1    1.6  1  APOBEC4_like     APOBEC4-like -AID/APOBEC-deaminase
  ------ inclusion threshold ------
      0.012   15.7   0.0       0.02   15.0   0.0    1.4  1  NAD2             Novel AID APOBEC clade 2
      0.034   14.2   2.0       0.13   12.3   2.0    1.9  1  Bd3614-deam      Bd3614-like deaminase


Domain annotation for each model (and alignments):
>> dCMP_cyt_deam_1  Cytidine and deoxycytidylate deaminase zinc-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.5   1.8   6.7e-30   1.2e-26       2     100 ..      16     121 ..      15     122 .. 0.93

  Alignments for each domain:
  == domain 1  score: 92.5 bits;  conditional E-value: 6.7e-30
                      HHHHHHHHHHHHHHHHHHTTTSCSEEEEEEETTEEEEEEESBHHCCTGTTB-HHHHHHHHHHHH.T.SSCE.......TTEEEEEEE--BHHHH CS
  dCMP_cyt_deam_1   2 ekdekllelalkaakeaqkcsnfkVGavivkngeiistgyngepaggsktiHAEvnAilkaakn.g.gskl.......egatlyvtlePCsmCa 86 
                      e+de +++ al++a++a ++ +++VG+viv++++i+++gyn+++++++ t HAE+ A  ++++n   +  l       +++tlyvt+ePC mCa
       EFC39039.1  16 EQDEIYMREALNMAQKALEELEVPVGCVIVHDNKIVGRGYNKTNQKKNATRHAELEAFDEITENySeE--LnnnvnffKECTLYVTVEPCVMCA 107
                      68999*********************************************************995444..345999999*************** PP

                      HHHHHHT-SEEEEE CS
  dCMP_cyt_deam_1  87 kaiiqsgikkvvvg 100
                       a+i ++i +vv+g
       EFC39039.1 108 SALILLKIGRVVCG 121
                      ************97 PP

>> MafB19-deam  MafB19-like deaminase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   90.5   2.3   4.3e-29   7.8e-26       2     134 ..      17     182 ..      16     186 .. 0.78

  Alignments for each domain:
  == domain 1  score: 90.5 bits;  conditional E-value: 4.3e-29
  MafB19-deam   2 dkekafrkalaevekatkikedkigavivkdkkviargsnekelnakataHaEiaalqqAakklkskrl......ddatlyvtlepCdmCagaivqag 93 
                  ++e ++r+al++++ka++  e+++g+viv+d+k+++rg+n+++++++at HaE +a+   ++  ++         +++tlyvt+epC mCa a++  +
   EFC39039.1  17 QDEIYMREALNMAQKALEELEVPVGCVIVHDNKIVGRGYNKTNQKKNATRHAELEAFDEITENYSEELNnnvnffKECTLYVTVEPCVMCASALILLK 114
                  6899*******************************************************999988876522222368********************* PP

  MafB19-deam  94 lkklvygagnpks............................lnkLkvkekngrvelv........eddckeilkgff 134
                  + ++v g++n+ +                             n+L+                   e +c eil++f 
   EFC39039.1 115 IGRVVCGCMNERFggcgsvlnihqscynslnhnhhhdqhgnNNQLNW---------KyecvhglfEKECIEILQRFY 182
                  ************99*97777766666555444444333333333333.........033334444777777777766 PP

>> SNAD4  Secreted Novel AID/APOBEC-like Deaminase 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.1   3.3e-08   5.9e-05      14      61 ..      58     111 ..      45     115 .. 0.73
   2 ?   -2.6   0.0       3.3     6e+03      55      67 ..     173     185 ..     170     188 .. 0.81

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 3.3e-08
       SNAD4  14 kgvlknkkehaEllflekikseldpsqe......yrvtwylswsPCaeCaekia 61 
                 ++  kn+++haEl  +++i+++++++ +       + t+y+++ PC+ Ca++++
  EFC39039.1  58 TNQKKNATRHAELEAFDEITENYSEELNnnvnffKECTLYVTVEPCVMCASALI 111
                 333444555**********996665555455687899*************9875 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 3.3
       SNAD4  55 eCaekiaeflaeh 67 
                 eC+e +++f++++
  EFC39039.1 173 ECIEILQRFYEQE 185
                 6999999999876 PP

>> APOBEC2  APOBEC2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   7.5e-07    0.0013      44      89 ..      60     110 ..      33     115 .. 0.73

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 7.5e-07
     APOBEC2  44 enkekkcHaEllflskvkk...kkleekkey..kvtwyvswsPCaeCaeev 89 
                 ++k++++HaEl  ++++++   ++l+++ ++  + t+yv+  PC+ Ca+ +
  EFC39039.1  60 QKKNATRHAELEAFDEITEnysEELNNNVNFfkECTLYVTVEPCVMCASAL 110
                 2235566*********9984434555555544479*************987 PP

>> APOBEC3  APOBEC3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.2   8.8e-07    0.0016      26      71 ..      61     111 ..      42     114 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 8.8e-07
     APOBEC3  26 knkekkHAEerfidkirslnldslkq.....ykitcylswsPcpkCaeelv 71 
                 k+++++HAE  + d+i + + ++l+       + t+y++  Pc  Ca+ l+
  EFC39039.1  61 KKNATRHAELEAFDEITENYSEELNNnvnffKECTLYVTVEPCVMCASALI 111
                 337899*********987554443321112257899************997 PP

>> Inv-AAD  Invertebrate-AID/APOBEC-deaminase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.2   1.8e-06    0.0032       7      68 ..      45     108 ..      41     119 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.8e-06
     Inv-AAD   7 adkneilatGytlel...eGnthaeqccliklaekhevaeeklaevlpkntvlYttmepCskRls 68 
                  ++n+i+ +Gy       + + hae  ++  ++e+++ + ++  + + k++ lY t+epC    s
  EFC39039.1  45 VHDNKIVGRGYNKTNqkkNATRHAELEAFDEITENYSEELNNNVN-FFKECTLYVTVEPCVMCAS 108
                 46799******87665557788**********9988655433333.567899********87655 PP

>> NAD1  Novel AID APOBEC clade 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.1   2.1e-06    0.0038      40      90 ..      53     111 ..      21     115 .. 0.71
   2 ?   -2.6   0.0       2.7   4.9e+03     135     148 ..     171     184 ..     138     201 .. 0.60

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 2.1e-06
        NAD1  40 kGvlen....eskcHaEllflnki...kslklldpsq..kykvtwylswSPCseCaskla 90 
                 +G+ +     +++ HaEl  +++i    s +l +++     + t+y++  PC  Cas l+
  EFC39039.1  53 RGYNKTnqkkNATRHAELEAFDEItenYSEEL-NNNVnfFKECTLYVTVEPCVMCASALI 111
                 45553323222334****99999944222333.3333346789*************9885 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.7
        NAD1 135 yeefeycwetfVen 148
                  +e+ ++++ f e+
  EFC39039.1 171 EKECIEILQRFYEQ 184
                 34444555555554 PP

>> APOBEC4_like  APOBEC4-like -AID/APOBEC-deaminase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.1   6.1e-06     0.011      19      74 ..      50     111 ..      32     121 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 6.1e-06
  APOBEC4_like  19 wggrgkiyrnrteksklehaevnflekirser.......kkvsctivwylsispCaecskrll 74 
                     grg   +n+ +k+ ++hae++  ++i+++         ++  + ++y+ + pC+ c+++l+
    EFC39039.1  50 IVGRGYNKTNQ-KKNATRHAELEAFDEITENYseelnnnVNFFKECTLYVTVEPCVMCASALI 111
                   55677777787.88999******99999987776677555566789**************997 PP

>> NAD2  Novel AID APOBEC clade 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.0   0.0   1.1e-05      0.02      47      94 ..      59     111 ..      12     117 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.1e-05
        NAD2  47 lnqkesklhaellfLskf...vlrqlelaqey..kvtwyvsWsPCpeCaaeva 94 
                  ++k++  hael   +++    +++l+ + ++  + t yv+  PC+ Ca+ ++
  EFC39039.1  59 NQKKNATRHAELEAFDEItenYSEELNNNVNFfkECTLYVTVEPCVMCASALI 111
                 33358899****999999766667888887765679*************9875 PP

>> Bd3614-deam  Bd3614-like deaminase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   2.0   7.5e-05      0.13      58      94 ..      74     110 ..      40     119 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 7.5e-05
  Bd3614-deam  58 deiadrdgdgeeerrpleegarllvtlqcCkmCAalv 94 
                  dei+++  +  +++    ++ +l+vt ++C mCA+ +
   EFC39039.1  74 DEITENYSEELNNNVNFFKECTLYVTVEPCVMCASAL 110
                  666666666666667777899*************765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       878  (0.0489709); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.49u 0.25s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 1408.84
//
Query:       EFC39040.1  [L=946]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-06   28.0   1.1    1.3e-06   28.0   1.1    2.7  2  zf-RING_11   RING-like zinc finger
     0.0057   16.5   7.2     0.0057   16.5   7.2    2.2  2  zf-C3HC4_2   Zinc finger, C3HC4 type (RING finger)
  ------ inclusion threshold ------
      0.094   13.1  18.3      0.022   15.1  14.3    2.2  2  zf-RING_2    Ring finger domain
        0.1   12.7   5.6       0.25   11.4   5.6    1.6  1  zf-ANAPC11   Anaphase-promoting complex subunit 11 RING-H2 fi
       0.15   12.1  14.8      0.084   12.8  11.3    2.4  2  zf-RING_5    zinc-RING finger domain
       0.94    9.4  16.2        0.3   11.0  12.0    2.5  2  zf-C3HC4     Zinc finger, C3HC4 type (RING finger)
        2.9    8.0   5.5        3.2    7.9   0.4    3.8  4  EIF_2_alpha  Eukaryotic translation initiation factor 2 alpha


Domain annotation for each model (and alignments):
>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1         2   5.1e+03      19      23 ..     203     207 ..     193     207 .. 0.70
   2 !   28.0   1.1   5.1e-10   1.3e-06       1      29 []     233     262 ..     233     262 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2
  zf-RING_11  19 pCsHt 23 
                  CsH+
  EFC39040.1 203 NCSHC 207
                 69*96 PP

  == domain 2  score: 28.0 bits;  conditional E-value: 5.1e-10
  zf-RING_11   1 eCsICLeefkpgqalfilp.CsHtFHfkCI 29 
                 +C ICL ++ +g  ++ l+ C+H+FH+ C+
  EFC39040.1 233 DCGICLLPLYDGTQIYNLEsCNHAFHLACV 262
                 8***************8866*********7 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       3.6   9.1e+03       9      20 ..     195     206 ..     193     208 .. 0.70
   2 !   16.5   7.2   2.2e-06    0.0057       2      37 ..     234     274 ..     233     278 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.6
  zf-C3HC4_2   9 lkdpsvvtpCgH 20 
                 +++  +v +C H
  EFC39040.1 195 IEEVEMVDNCSH 206
                 556667888988 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 2.2e-06
  zf-C3HC4_2   2 CpiCldmlkdpsvvt...pCgHvfCqkCilrsLeekn..eC 37 
                 C iCl  l+d++ +     C+H f+  C++r +e+ n  +C
  EFC39040.1 234 CGICLLPLYDGTQIYnleSCNHAFHLACVHRCMESRNiqKC 274
                 ***********98877889***************9986555 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1       3.1   7.9e+03      19      24 ..     202     207 ..     193     211 .. 0.63
   2 ?   15.1  14.3   8.6e-06     0.022       2      43 ..     233     278 ..     232     279 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 3.1
   zf-RING_2  19 lpCgHv 24 
                 + C+H+
  EFC39040.1 202 DNCSHC 207
                 358876 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 8.6e-06
   zf-RING_2   2 eCpICleelssadsvlll.pCgHvfhreClerwlrssst...CPlC 43 
                 +C+ICl +l ++ ++  l  C+H fh  C+ r ++s++    C  C
  EFC39040.1 233 DCGICLLPLYDGTQIYNLeSCNHAFHLACVHRCMESRNIqkcCVKC 278
                 7********99999996658************98888879977767 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   5.6   9.9e-05      0.25      31      81 ..     230     282 ..     223     286 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 9.9e-05
                 TTS--TTCSTTTTTS-EE..EBTTS-EEEHHHHHHHHHHHSTSSB-TTTSSB- CS
  zf-ANAPC11  31 fdGtcpsckfpGddcplv..lGkckhnfhlhcilkwletetskglcpmcrqtf 81 
                  +  c  c +p  d + +  l +c+h+fhl c+ + +e+++ ++ c  c +++
  EFC39040.1 230 INCDCGICLLPLYDGTQIynLESCNHAFHLACVHRCMESRNIQKCCVKCFKEI 282
                 56678888888766665512457***********************9997765 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.9       0.4     1e+03       2      22 ..     204     234 ..     203     237 .. 0.71
   2 ?   12.8  11.3   3.3e-05     0.084       2      42 ..     234     278 ..     233     280 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.4
   zf-RING_5   2 CnkCfekl..........skeekfyltsCgH 22 
                 C++C+++           +k+e+f+  +C  
  EFC39040.1 204 CSHCSSSSeevevgnnqiEKKEAFVDINCDC 234
                 7777777766688888878888888888865 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 3.3e-05
   zf-RING_5   2 CnkCfekl.skeekfyltsCgHifCekClkkll...ekeavCpiC 42 
                 C +C  +l  +++ + l sC H f+ +C+++++   + +++C  C
  EFC39040.1 234 CGICLLPLyDGTQIYNLESCNHAFHLACVHRCMesrNIQKCCVKC 278
                 ********999999*********************8888888889 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.7   4.3e+03      13      19 ..     200     206 ..     192     211 .. 0.62
   2 ?   11.0  12.0   0.00012       0.3       1      41 []     234     278 ..     234     282 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.7
                 .E-TTS- CS
    zf-C3HC4  13 elleCkH 19 
                 ++++C H
  EFC39040.1 200 MVDNCSH 206
                 5666766 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00012
                 -TTT-S--SS-E....E-TTS--B-CHHHHHHHHCTSSB-.-TTT CS
    zf-C3HC4   1 CpiCleeakepn...elleCkHsfCskCirkilksrkkvk.CPlC 41 
                 C iCl  + + +    l  C+H+f+ +C+ ++++sr+ +k C +C
  EFC39040.1 234 CGICLLPLYDGTqiyNLESCNHAFHLACVHRCMESRNIQKcCVKC 278
                 899999998888888999****************97777757777 PP

>> EIF_2_alpha  Eukaryotic translation initiation factor 2 alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       4.6   1.2e+04      18      50 ..     277     314 ..     268     331 .. 0.54
   2 ?   -1.7   0.1       1.1   2.9e+03      34      51 ..     418     435 ..     385     441 .. 0.66
   3 ?   -2.3   0.0       1.8   4.6e+03      68      86 ..     553     571 ..     547     585 .. 0.72
   4 ?    7.9   0.4    0.0013       3.2      43      99 ..     711     766 ..     586     792 .. 0.72

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.6
                  HHHHHHHSTTH.....HHHHTTS-TTTHHHHHHCTHHH CS
  EIF_2_alpha  18 daFklaitdee.....vldkleipeeveeaLveiikkk 50 
                  ++Fk + +de+      +++   ++ +e+ + ++ k k
   EFC39040.1 277 KCFKEISQDEKkqiklLFKEEVRTKRIEKRVSNNPKPK 314
                  55665555555444433444334444444444444444 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.1
                  TS-TTTHHHHHHCTHHHH CS
  EIF_2_alpha  34 eipeeveeaLveiikkkl 51 
                  e++e+++e+L ++ +k++
   EFC39040.1 418 ELTEKIKEQLEDKTSKRI 435
                  345666666666666655 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 1.8
                  STTHHHHHHHHHHHHST.S CS
  EIF_2_alpha  68 tkdGveaIkeaLkageeas 86 
                  +++G++  ++ Lk  +e s
   EFC39040.1 553 NYHGIQSTRSLLKGLTEYS 571
                  699*********9555533 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0013
                  HHHCTHHHHHHT-EEEEEEEEEEE-STTHHHHHHHHHHHHST.S..TTSSSEEEEEE CS
  EIF_2_alpha  43 LveiikkklkpqkvkiradieltcftkdGveaIkeaLkageeasneeeveeeeevki 99 
                  +   i +++  q+v ++    +  ++  G+eaI++ L ++ + +++ ++ +e+++ i
   EFC39040.1 711 IDYFIVENMDLQTVLLNLITIIDHIERTGIEAIRKCLLKSYGIDED-KERDENQMVI 766
                  55557788888888888888889999************77664433.3444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (946 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1527  (0.0851693); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.87u 0.31s 00:00:01.18 Elapsed: 00:00:00.53
# Mc/sec: 5333.03
//
Query:       EFC39041.1  [L=341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-29  101.2  13.9    5.8e-27   94.8  13.9    2.0  1  Zip       ZIP Zinc transporter


Domain annotation for each model (and alignments):
>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.8  13.9   3.2e-31   5.8e-27       5     331 ..      15     329 ..      11     330 .. 0.86

  Alignments for each domain:
  == domain 1  score: 94.8 bits;  conditional E-value: 3.2e-31
         Zip   5 ilaiiaililsllgllgpllvpkiskl.....lsklllslllafavGvllgtaflhLlPealealeesqleeehth........plagllvllGfllll 90 
                  +a+++++++  +g ++p+ ++k +++     ++  +lsl+ ++++G +++ af h+l  ++ ++++  +              +++++l+ +Gf+l l
  EFC39041.1  15 SIAVLVVFCSAWVGAILPFAIKKFNCTfcsdqRQATILSLVNCLSGGFFISAAFYHILISSVTSFKQLTQLM---GgkgisaygTFPFMLASIGFVLPL 110
                 5899********************************************************999999986533...1346689***************** PP

         Zip  91 lveklltmivekksshkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqaseeedkeklaslkvraiil 189
                 +v ++l+ + +k         k++++++ es++ ++ ++ +++ +e                                   ee++++ ++  k+++++l
  EFC39041.1 111 FVHNILNAFTAK--------IKNEQNQDHESDDTNQLYALNSDINEL----------------------------------EEKKESGVSYNKIVSYVL 167
                 *********999........222222222222222222222222222..................................11222334455799**** PP

         Zip 190 llglilHsfidGLAlGvssssstgislfiAvllHelpeelglgaiLlkaglsrkkav.llnllfaltaplGiliGilvrs.isessgaeivsgillals 286
                    l+  s+ +G+  Gv  +ss +++l+ +++lH+ ++++++ +  ++agl+ ++    l l+f+l++p+Gi+iGil+   +  +   +iv  i+ +l 
  EFC39041.1 168 STVLSCQSVLIGVTSGVITDSSDAMVLICTMILHKWVAAFSISVSSIRAGLPFWTRTmPLMLVFSLMTPIGIIIGILLVRfVTDKVVFLIVGIIFKSLG 266
                 *******************************************************999999****************999*9999999*********** PP

         Zip 287 aGtflYvalvellphEllnek..................gssslkqsllqllglllGfalmll 331
                 aG f+Yv+++ +l +E++ ++                   s++   +ll+ll++++G+++m +
  EFC39041.1 267 AGFFIYVSTMIILRNEIALPNqstsgchsqnakneqksiTSRQRNVFLLKLLFVFIGYMIMTI 329
                 *************99*9999999**************998889999***************75 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1051  (0.0586201); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.57
# Mc/sec: 1811.65
//
Query:       EFC39042.1  [L=145]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-10   40.7   0.0    2.7e-10   40.3   0.0    1.2  1  DUF1398   Protein of unknown function (DUF1398)


Domain annotation for each model (and alignments):
>> DUF1398  Protein of unknown function (DUF1398)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.3   0.0   1.5e-14   2.7e-10      11     118 ..      22     132 ..      12     133 .. 0.87

  Alignments for each domain:
  == domain 1  score: 40.3 bits;  conditional E-value: 1.5e-14
                 ---HHHHHHHHHH-SSEEEEETTTSEEEEE-SSS-EEEEE-S....TT-----S---HHHHHHHHHHHHHT---HHHHHHHHHHTT--EEEEETTTTEE CS
     DUF1398  11 adfpafiqelkrlgvskYeyfvadgnvkyvgendevvevkak....rellkvaekknaelikaalkkhqqgettfetfcedlAkaGvekWivdleektr 105
                   fp +++ l+r g+++   f+   +  y+++++e v  +++    + + ++++  n++l+  a++k q+get+f +f + + + Gv+ + vd+ ++++
  EFC39042.1  22 GKFPYLAETLRRAGIERNRWFLPGCTSIYYTSSGEKVVNQMEsllpYGMHEIKPF-NRNLVVDAIRKDQAGETEFPQFLKCIWEGGVVSYEVDFVNRVC 119
                 679999*****************99999**9999877666542222667777764.7899999************************************ PP

                 EEE-TT--EEEEE CS
     DUF1398 106 tYydkdnsllliE 118
                 tYy  d+++ ++E
  EFC39042.1 120 TYYGADEKEFYEE 132
                 **********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (145 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       366  (0.0204139); expected 358.6 (0.02)
Passed bias filter:                      297  (0.0165653); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.45
# Mc/sec: 963.90
//
Query:       EFC39043.1  [L=974]
Description: hypothetical protein NAEGRDRAFT_59338 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-08   33.5  10.8    7.6e-08   32.4  10.8    1.6  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
      0.074   13.4   0.6       0.18   12.1   0.6    1.6  1  TPR_12    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.4  10.8   8.4e-12   7.6e-08       2      39 ..     375     411 ..     374     412 .. 0.96

  Alignments for each domain:
  == domain 1  score: 32.4 bits;  conditional E-value: 8.4e-12
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 +C++Cr k++KC+++ PaCs C  ++ +C  y++++k+
  EFC39043.1 375 SCTSCRAKHRKCSKELPACSYCLARGITCI-YRKPKKK 411
                 8*****************************.9999987 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.6     2e-05      0.18       4      68 ..     617     682 ..     613     683 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 2e-05
      TPR_12   4 talnnlaavlrrlgrydeAlellekaleiarrllGpdh.pltattlrnLgrlyralgryeeAlell 68 
                  +++  a++++r g  +eA + +++a++i +r++++++  l a +++nL+ + +  g+++eA  +l
  EFC39043.1 617 LLYSIHALMCQRKGLKHEAASACNQARNILSRVFDKNNdFLIACAYCNLSVYSSGEGNLAEAKFYL 682
                 45555899*************************999998999**********99*******98776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (974 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2022  (0.112778); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.94u 0.29s 00:00:01.23 Elapsed: 00:00:00.48
# Mc/sec: 6056.17
//
Query:       EFC39044.1  [L=356]
Description: Sir2 NAD-dependent protein deacetylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-05   23.5   5.2    0.00076   19.5   4.6    2.2  2  SIR2      Sir2 family


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.0   0.00081        15       1      69 [.      43     113 ..      43     126 .. 0.67
   2 !   19.5   4.6   4.2e-08   0.00076      18     147 ..      92     240 ..      89     256 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.00081
                 -GGGGGGGT---SSS..TTSHHHH..SCHHHHSSHHHHHHHHHHHHHHHHHHHHHHHCCTSS--HHHHHHHHH CS
        SIR2   1 GAGiStesGipdfRs..keGlyak..lakeelaspealfskkllveevfyniarellaeeaepnaaHkalkkl 69 
                 GAG S +sG+  +++  ++ +y++  l+ ++la p   f++++   + +y +  +  + ++  +++H+  + l
  EFC39044.1  43 GAGFSKDSGLAVYKDiaSNPIYQEknLTYHDLARPVSTFETEQELLD-YYGFWVNCAQ-SYLNTPSHSGYQIL 113
                 9*************99899***8722455679999888888777777.5555555444.33344444433333 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 4.2e-08
                 SHHHHSCHHHHSSHHHHHHHHHHHHH..HHHH..HHHHHHCCTSS--HHHHHHHHHHHTTCEEEEEES-SSSHHHHTT-S.SEEETTEEEEEEEE.TTT CS
        SIR2  18 Glyaklakeelaspealfskkllvee..vfyn..iarellaeeaepnaaHkalkklekkgkllrliTQNiDgLekkaGsk.kvvelHGslakakc.vkc 110
                 G++ ++a++ l++p++   + l+ ++   +++  i +e  ++++e   a ++ k+  k ++++ ++  N+D+  ++   k +++++HG +++ +c ++c
  EFC39044.1  92 GFWVNCAQSYLNTPSHSGYQILKDWKqlLYSKkeIQKEFNEKQIEILSASQWWKENCKIASNMFIYSSNVDNHFSRYFEKeEIYNIHGHALNWQCgNHC 190
                 89999999999999888777777777643333113333444456666666677777777788999******9766665555*************95346 PP

                 SBEEECC...GGHCHHHCCTT............B-TTTCCBEEEEE--CTS CS
        SIR2 111 ekkldke...elqeeieaekvp...........ecekcgkllkpdvvfFGe 147
                 ++ + ++   +lq+ i +++ +           +cekc+++  p+v +FG+
  EFC39044.1 191 NEDCVWNftkQLQNIIINQE-TlqidneklkelKCEKCQHASMPNVLMFGD 240
                 55554431002333332332.14699999*********************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       927  (0.0517039); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.24s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 2383.65
//
Query:       EFC39045.1  [L=498]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-22   80.4   0.1    2.2e-22   79.7   0.1    1.4  1  Peptidase_M1    Peptidase family M1 domain
    1.4e-19   71.0   8.0    1.4e-19   71.0   8.0    2.6  2  Peptidase_M1_N  Peptidase M1 N-terminal domain
  ------ inclusion threshold ------
      0.081   13.4  11.6      0.039   14.4   7.9    2.1  2  DUF4171         Domain of unknown function (DUF4171)


Domain annotation for each model (and alignments):
>> Peptidase_M1  Peptidase family M1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.7   0.1   3.7e-26   2.2e-22       3     203 ..     297     497 ..     295     498 .] 0.82

  Alignments for each domain:
  == domain 1  score: 79.7 bits;  conditional E-value: 3.7e-26
                   HHHHHHHHHHHHHHHT...S--SSSEEEEEEESSTTS.SEEEETTEEEEEGGGC-SSTTTS-HHHHHHHHHHHHHHHHHHHBTTTEEESSGGGGHHH CS
  Peptidase_M1   3 levtkkllefleeyfk...vpYplpkldlvalpdfsa.gAMEnwglityreelllvdpenssesdkrsvaeviaHElaHqWfGnlVtmkwWddlwLn 95 
                   le++ k+l +le+yf+   ++ ++ kld +++p+    g+MEnw++it+ e++ + +  + ++++    +e+ aHEl+H W+GnlV +     + ++
    EFC39045.1 297 LEMSCKILPLLEDYFDqsiLKQNISKLDWIIVPELIIgGGMENWSCITLLEKHTANT--SMDMKKLGPFVEILAHELSHFWVGNLVGFP----FHIK 387
                   6788899999999997333566788*********999789************99988..777788899*******************85....89** PP

                   HHHHHHHHHHHHHHHSCCCH.CHHHHHHHCHHHHHHHHTSTTHHHSSGG-GSHHHHHHTSSHHHHHHHHHHH.HHHHHHCTHHHHHHHHHHHHHHCT CS
  Peptidase_M1  96 EGfatyleylildklepewe.vseqllleeveealsedaldeshpitqevekpseidevFdsiaYeKGasll.rmlekllgeevFqkglksYlkefk 190
                   EG+a+yle  i+d++ + ++ ++ +   ++++++    +++++++   +++ ++  +++F+ +aY++ + ++ +    +lg+ vF++ l++++++++
    EFC39045.1 388 EGLAMYLEKIITDQVLKRANsITIKKNDKKNNNTSIISEIKSASNNDANLSVEQMFQKMFTGVAYTQCFDFIcNECVGTLGPTVFRDRLRQVISDNE 484
                   ****************966633333323344444444444554444468888999**************9873678899****************** PP

                   TEEE-HHHHHHHH CS
  Peptidase_M1 191 yknaetedlwdal 203
                   ++ ++++d+++++
    EFC39045.1 485 FGFVNEDDFVQSF 497
                   *********9876 PP

>> Peptidase_M1_N  Peptidase M1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.0   8.0   2.3e-23   1.4e-19       2     186 .]      13     249 ..      12     249 .. 0.69
   2 ?   -1.9   0.4      0.54   3.2e+03      30      56 ..     404     430 ..     395     452 .. 0.48

  Alignments for each domain:
  == domain 1  score: 71.0 bits;  conditional E-value: 2.3e-23
                     EEEEEEEEEEETT.........TTEEEEEEEEEEEES.S-ECEEEEEESSEEE.....................................ECEEE CS
  Peptidase_M1_N   2 pehYdldlkidlk.........ektfkGsvtitlqlk.eatseivldakdlki.....................................ksvsl 49 
                     p+hY+l+++++ +         + ++++s+ti+ +++  + ++ +l + +l+                                      +s + 
      EFC39045.1  13 PSHYELSITLSDDffsektngsDISYSASLTIHCNIVnDEDDNYILPSIELDCnsdrieifgvsieknknklkgtlfeqnkkpistssnsSSSKN 107
                     67777777776666777777766677777777777774333333333333333333336677777777777777777776644444433211111 PP

                     EECTTCTCEEEEEEEECTTTTC...............EEEEECCEEETTCEEEEEEEEEEE-...BSSSSEEEEEEEEETSCEEEEEEEE-TTTT CS
  Peptidase_M1_N  50 saevksesvkidfkieqkdeel...............ltiklkeslqqtskytLeieyegel...ndklaGlykstYtdkgekkvvvvTqfeatd 126
                      +++k+++++ +         +               l+ik + ++ + +ky+++i ++g +   ++ + Gl+ s   ++     +++++fea++
      EFC39045.1 108 EQKKKKNDKSCN---------HnhnnnnseissnkkgLIIKSPIEPFTLGKYEIKISFKGIIvpsKKAMSGLFYSIHSKNSS--KIICSHFEAHF 191
                     222222333333.........2333334455788888999*9999999************99**99*******988666644..5********** PP

                     GGGTS-B--STTSEBEEEEEEEE.ETTSEEEESSECCCEEEETTCEEEEEEEEEESBEGGG CS
  Peptidase_M1_N 127 ARsafPCfDePsvKAtftisika.pkeetalSnmpeeeseklengqkiteFeqtpkmstYL 186
                     A +afPCfD   +KAtf++ i   ++++  +Snm+++++++   ++k++ F+++pkms YL
      EFC39045.1 192 AHYAFPCFDDWTQKATFQLGISNlNSNYKCISNMSVKMKND---SKKTVMFNTSPKMSIYL 249
                     *********************8715556********95554...557*************8 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.54
                     S-ECEEEEEESSEEEECEEEEECTTCT CS
  Peptidase_M1_N  30 eatseivldakdlkiksvslsaevkse 56 
                     + +++i++ ++d k ++ s+++e ks 
      EFC39045.1 404 KRANSITIKKNDKKNNNTSIISEIKSA 430
                     444445554444444343333333222 PP

>> DUF4171  Domain of unknown function (DUF4171)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   7.9   6.6e-06     0.039      30      86 ..      93     151 ..      82     181 .. 0.82
   2 ?   -0.5   0.1      0.27   1.6e+03       3      41 ..     391     431 ..     390     441 .. 0.66

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 6.6e-06
     DUF4171  30 ypsvsssssSksrkrehkkklssssseskkddsssskskkfkpgavkt..epLtLread 86 
                   ++s+ss+S s+k+e+kkk ++ s +++ ++++s+ s+  k+++ k+  ep tL   +
  EFC39045.1  93 KKPISTSSNSSSSKNEQKKKKNDKSCNHNHNNNNSEISSNKKGLIIKSpiEPFTLGKYE 151
                 35889999999999******************************998655999997655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.27
     DUF4171   3 amdLlkaitSP.l.atgskpskklheKpsypsvsssssSks 41 
                 am L k it   l  + s   kk  +K   +s+ s+ +S s
  EFC39045.1 391 AMYLEKIITDQvLkRANSITIKKNDKKNNNTSIISEIKSAS 431
                 67777777777322355666778888877777777666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2085  (0.116292); expected 358.6 (0.02)
Passed bias filter:                      675  (0.0376485); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.77u 0.31s 00:00:01.08 Elapsed: 00:00:00.51
# Mc/sec: 2929.82
//
Query:       EFC39046.1  [L=1069]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.1e-67  226.1   1.5    5.1e-67  226.1   1.5    2.9  3  SNF2_N           SNF2 family N-terminal domain
    2.4e-39  133.9   3.6    2.4e-39  133.9   3.6    4.5  5  SLIDE            SLIDE
    7.4e-21   74.6   2.2    1.8e-20   73.3   0.0    2.9  3  Helicase_C       Helicase conserved C-terminal domain
    1.7e-05   24.6   0.2     0.0006   19.6   0.0    2.8  2  DEAD             DEAD/DEAH box helicase
    0.00035   20.7   8.2      0.036   14.3   0.0    3.2  3  Myb_DNA-binding  Myb-like DNA-binding domain


Domain annotation for each model (and alignments):
>> SNF2_N  SNF2 family N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.5      0.67   2.4e+03     250     304 ..      85     138 ..      71     180 .. 0.64
   2 !  226.1   1.5   1.4e-70   5.1e-67      51     349 ..     214     479 ..     203     480 .. 0.89
   3 ?   -2.1   0.6      0.34   1.2e+03     278     327 ..     731     777 ..     624     799 .. 0.50

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 0.67
                 HHHHHHHHHHHHTT-STTEE---GGGT--S---EEEEEEEEE--HHHHHHHH... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 250 eaqaekgrsrLlqllqrlmlrrakkdveknlPpkteeiiflklskverksYnrll 304
                  ++ ek r++  +ll+rl  ++ k+ v ++ P+ +++++f +l + + ++Y    
  EFC39046.1  85 SKHLEKIRKEQKSLLNRLKEKQKKELVGIEDPQEKVKVTFRHLLE-QTEIYSSFT 138
                 355567777778888888888888888888888888888888864.667777444 PP

  == domain 2  score: 226.1 bits;  conditional E-value: 1.4e-70
                 HHHTT--EEE---TTS--HHHHHHHHH...HHTTTS---.......S-EEEE--HHHHHHHHHHHHHH-TTS-EEE--SSHHHH--------------- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N  51 akqsvrGGiLaDemGLGKTvqvlalilaqrakeekdkekkrkdtlagptLivvPaslldqWeneierhvsssalrvlvyggqkkmkkkntkvapkllad 149
                 ++    +GiLaDemGLGKTvq+l+ i+   + + +++        +gp+L++vP+s++ +W+n+ +++++s ++  +++++++    ++ k +  +  +
  EFC39046.1 214 LHDRGVNGILADEMGLGKTVQTLTWIA---YLKFIRRI-------RGPHLVIVPKSVIPNWVNQANQWCPSLQVLKFHGDKDQ---RREIKEKSLVGGK 299
                 5667889********************...76666665.......5*************************987555555543...3434566677899 PP

                 --EEEE-HHHHHHHT......TTS-S-S-SEEEES-GGGT--TTSHHHHHHHH---S-EEEE-S--SSS-HHHHHHHHHHH-TTTT--HHHHHHHTHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 150 ydvvittYdvlsreaelqkkrsvlkqvewkrvvlDEghtlknstskaaeavskLstsnrwiltGTPiqnsledlygLlkfLreepfgekqtfdkllqrp 248
                 +++v+t+Y++  +e+       +l++ +w  +++DE+h++kn++s +++ v+ ++ ++r++ltGTP+qn+l++l++Ll+fL +++f + + fd++++ +
  EFC39046.1 300 FEIVVTSYETAIKEK------AALNKFRWYSIIIDEAHRIKNENSILSQSVRVFDCQYRLLLTGTPLQNNLHELWSLLNFLLPDVFRSADDFDTWFNLK 392
                 ************998......9***************************************************************************** PP

                 HHHHHHHHHHHHHTT-STTEE---GGGT--S---EEEEEEEEE--HHHHHHHH....................HHHHHH-HHH-HHHHHHHHHHHHH-- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 249 ieaqaekgrsrLlqllqrlmlrrakkdveknlPpkteeiiflklskverksYnrllevlrkkalakllkrseaalkssskskekilelllelrqacnhp 347
                   + +++ + +L+++l++++lrr k++v+ ++Ppk+e  + + lsk ++++Y             ++l+++  ++k ++  k ++l+ +++lr++cnhp
  EFC39046.1 393 EGQAETHIIDQLHKVLKPFLLRRLKTEVKTDIPPKKEIYVECGLSKLQKEWYR------------SILTKDLNSIKGGE--KVRLLNVVMQLRKCCNHP 477
                 *****************************************************............55555555555555..3459************** PP

                 -X CS
                 xx RF
      SNF2_N 348 ql 349
                 +l
  EFC39046.1 478 YL 479
                 98 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.34
                 -S---EEEEEEEEE--HHHHHHHH....................HHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      SNF2_N 278 knlPpkteeiiflklskverksYnrllevlrkkalakllkrseaalksss 327
                 + l   ++ +++++l+k   k Y+    + +kk  +++l+ +e alk++s
  EFC39046.1 731 EGLDYSKKATTMISLEKLVSKNYK---AKFCKKNDKFILQLEEEALKEES 777
                 235555666666666666666676...33333334444444444444444 PP

>> SLIDE  SLIDE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   2.0       1.2   4.4e+03      10      50 ..      84     122 ..      72     133 .. 0.60
   2 ?   -2.6   0.0       1.5   5.4e+03      12      41 ..     160     189 ..     157     211 .. 0.69
   3 ?    0.8   0.9      0.13   4.8e+02      40      63 ..     745     768 ..     693     784 .. 0.69
   4 ?   -4.5   2.0         5   1.8e+04      52      52 ..     876     876 ..     831     913 .. 0.48
   5 !  133.9   3.6   6.8e-43   2.4e-39       1     114 []     928    1039 ..     928    1039 .. 0.98

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.2
       SLIDE  10 gekkiek.lkelkellkkkveqyknplqelkikyppsnkgkk 50 
                 + k +ek +ke+k+ll++  e++k+ l  ++    p++k k+
  EFC39046.1  84 TSKHLEKiRKEQKSLLNRLKEKQKKELVGIE--D-PQEKVKV 122
                 4555555235566677777666666554443..2.4444444 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.5
       SLIDE  12 kkieklkelkellkkkveqyknplqelkik 41 
                 +k  +++e +e++++ +e+ ++  q + ++
  EFC39046.1 160 RKHSEKEEDEEIIREALEDEEESYQGVLLT 189
                 566777778888888888777766655554 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.13
       SLIDE  40 ikyppsnkgkkeyteeeDrfllvl 63 
                 ++  +s++ k ++ +++D+f+l+l
  EFC39046.1 745 LEKLVSKNYKAKFCKKNDKFILQL 768
                 334455556667999999999986 PP

  == domain 4  score: -4.5 bits;  conditional E-value: 5
       SLIDE  52 y 52 
                 +
  EFC39046.1 876 W 876
                 2 PP

  == domain 5  score: 133.9 bits;  conditional E-value: 6.8e-43
       SLIDE    1 ekiikqIekgekkieklkelkellkkkveqyknplqelkikyppsnkgkkeyteeeDrfllvllakyGygnyekikkeiresplFrfDwflksrtpq 97  
                  +k+ik+Ie+ge++++k ++ + +l+ k+++y np+ e+k++y  +n+ k  +t eeD f+ +++ak+Gyg +e+++++ir++++FrfDwf+k+rt+ 
  EFC39046.1  928 DKLIKRIERGESQLQKIDNNNLMLRYKTQKYINPWLEMKFNY-GQNQVKE-FTPEEDSFICCMTAKLGYGFWEEVRAQIRNAWEFRFDWFIKTRTAV 1022
                  79****************************************.8888887.********************************************** PP

       SLIDE   98 elqkRcetLlklvekel 114 
                  e+qkRc+tL+kl+eke+
  EFC39046.1 1023 EIQKRCDTLIKLIEKEY 1039
                  ***************96 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.96   3.4e+03      42      73 ..     276     306 ..     248     343 .. 0.66
   2 !   73.3   0.0     5e-24   1.8e-20       6     111 .]     505     614 ..     500     614 .. 0.87
   3 ?   -3.9   0.4       4.8   1.7e+04      23      62 ..     758     801 ..     745     805 .. 0.59

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.96
                 TEEEESTTSTHHHHHHHHHHHH.TTSSSEEEES CS
  Helicase_C  42 kvavlhgelpqnereeileqfn.kgesdvLiat 73 
                 +v+++hg   +++r+ei e+    g++ +++++
  EFC39046.1 276 QVLKFHG--DKDQRREIKEKSLvGGKFEIVVTS 306
                 5566666..455555555444334555555544 PP

  == domain 2  score: 73.3 bits;  conditional E-value: 5e-24
                 HHHHH.HHTTTTSEEEEEESSHHHHHH.HHHHHHHTTSTEEEESTTSTHHHHHHHHHHHH...TTSSSEEEESGGGTSSSTSTTESEEEESSSSSSHHH CS
  Helicase_C   6 llell.kleeeggkilifvntidrlek.vklllekkgikvavlhgelpqnereeileqfn...kgesdvLiatdvaerGidipkvnlVinfdlprnvts 99 
                 + +ll kl+e+++++lif++ +++l+   ++    +++++++++g+++++ re+ +++fn   + ++ +L++t++++ Gi++  +++Vi++d ++n++ 
  EFC39046.1 505 VDKLLkKLKEQNSRVLIFTQMTRMLDIlEDYC-YLRNYEYCRIDGQTSSELREQHMDEFNkegSSKFIFLLSTRAGGLGINLATADTVIIYDSDWNPQA 602
                 45666899*****************7754444.3347***********************7555666799***************************** PP

                 HHHHHTTSSSTT CS
  Helicase_C 100 yiqriGRtgRag 111
                   q+ +R++R+g
  EFC39046.1 603 DLQAQDRCHRIG 614
                 **********97 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 4.8
                 ESSHH....HHHHHHHHHHHT.TSTEEEESTTSTHHHHHHHHHHH CS
  Helicase_C  23 vntid....rlekvklllekk.gikvavlhgelpqnereeileqf 62 
                 +++ d    +le  + l+e++  +++ +l  + +q e++ ++e+ 
  EFC39046.1 758 CKKNDkfilQLE-EEALKEESqTVRSERLGRRNKQTEQQIAIEEA 801
                 444443322232.33443333367777777777777777777765 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   1.7e-07    0.0006      15     136 ..     219     336 ..     206     364 .. 0.74
   2 ?    1.4   0.4     0.064   2.3e+02      76     154 ..     619     713 ..     604     729 .. 0.64

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 1.7e-07
                 CEEEEEESTTSSHHHHHHHHHH..HHHHHSTTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHH..TT.CSEEEEEHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xx.xxxxxxxxxxx RF
        DEAD  15 gdvlvaaeTGsGKTlaflipvl..qivyetkgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskld..ng.vdivvgtpgrl 108
                  + ++a e G GKT   l  +   + +    ++ +   l+++P ++ + + +n++++++    l+vl + g++++r+++++ +   g  +ivv+  +  
  EFC39046.1 219 VNGILADEMGLGKTVQTLTWIAylKFI----RRIRGPHLVIVP-KSVIPNWVNQANQWCPS--LQVLKFHGDKDQRREIKEKSlvGGkFEIVVTSYETA 310
                 566788899*****9866555510444....455556788888.5778999*********7..8899888877776666665433336********999 PP

                 HHHHHCTSSHCTTEEE..EEEETHHHHHHT CS
                 xxxxxxxxxxxxxxxx..xxxxxxxxxxxx RF
        DEAD 109 ddllstgklnlsqvrf..lVlDEadrlldq 136
                 ++  ++    l+++r+  +++DEa+r+ ++
  EFC39046.1 311 IK--EKAA--LNKFRWysIIIDEAHRIKNE 336
                 98..5455..77776666********9987 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.064
                 SEEEEEETTSSHHHHHHHHH.TT..CSEEEEEHHHHHHHH....HCTSSH.........CTTEEEEEEET.HHHHHHTTTHHHHHHHHHHSHHHCT CS
                 xxxxxxxxxxxxxxxxxxxx.xx..xxxxxxxxxxxxxxx....xxxxxx.........xxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  76 lrvlliiggvaardqlskld.ng..vdivvgtpgrlddll....stgkln.........lsqvrflVlDE.adrlldqgfsdfinrilnqlpqitc 154
                 ++v  +i++++ ++++ +   ++  +d vv   grl++      +t+ ++         +++ +  + DE  d +l+   +++i++i +q ++i++
  EFC39046.1 619 VNVYRLISKDSIEEKIYQRAvKKlyLDAVVIQQGRLAEQNnklsKTELMSmikfgaeevFKSTESTITDEdLDAILSR-GEQKIQEIDQQYKNICQ 713
                 566666777777666666642446799999999999995445652333325555566668888888888866888887.67778887777755544 PP

>> Myb_DNA-binding  Myb-like DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.3   1.5         5   1.8e+04       6      15 ..     166     175 ..     165     177 .. 0.53
   2 !   14.3   0.0     1e-05     0.036       3      41 ..     875     913 ..     874     917 .. 0.92
   3 !   10.6   0.1   0.00014      0.52       3      41 ..     976    1027 ..     975    1031 .. 0.75

  Alignments for each domain:
  == domain 1  score: -5.3 bits;  conditional E-value: 5
                      HHHHHHHHHH CS
  Myb_DNA-binding   6 eeEdelLlea 15 
                      ee++e++ ea
       EFC39046.1 166 EEDEEIIREA 175
                      4555555555 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1e-05
                      SSBHHHHHHHHHHHHHHT.TCHHHHHHHHTSS-HHHHHHH CS
  Myb_DNA-binding   3 kWteeEdelLleavkkhG.nrWkkIaerlggRtekqcrsr 41 
                      +W++ + + ++++++k+G ++++ Ia ++  +te q++ +
       EFC39046.1 875 NWSKKDFQSFIKGCEKFGrKDYANIAVEV-EKTEQQIKKY 913
                      8*****************999********.6******865 PP

  == domain 3  score: 10.6 bits;  conditional E-value: 0.00014
                       SSBHHHHHHHHHHHHHHT.TCHHHH.HH...........HHTSS-HHHHHHH CS
  Myb_DNA-binding    3 kWteeEdelLleavkkhG.nrWkkI.ae...........rlggRtekqcrsr 41  
                       ++t+eEd  + +  +k+G + W+++ a+            + +Rt+ +++ r
       EFC39046.1  976 EFTPEEDSFICCMTAKLGyGFWEEVrAQirnawefrfdwFIKTRTAVEIQKR 1027
                       79***********************666555555544444445888877766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1069 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3066  (0.171008); expected 358.6 (0.02)
Passed bias filter:                      679  (0.0378716); expected 358.6 (0.02)
Passed Vit filter:                       179  (0.00998383); expected 17.9 (0.001)
Passed Fwd filter:                        51  (0.00284455); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.53u 0.35s 00:00:01.88 Elapsed: 00:00:00.61
# Mc/sec: 5307.43
//
Query:       EFC39047.1  [L=658]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.8e-53  180.6  17.6    6.3e-53  180.2  17.6    1.1  1  ABC_membrane  ABC transporter transmembrane region
    2.3e-32  112.4   0.0    4.2e-32  111.5   0.0    1.5  1  ABC_tran      ABC transporter
    9.5e-07   28.5   1.7    0.00025   20.6   1.7    2.4  1  SMC_N         RecF/RecN/SMC N terminal domain
    0.00082   19.1   0.7     0.0028   17.4   0.2    2.2  2  AAA_29        P-loop containing region of AAA domain
      0.003   18.0   0.1       0.01   16.2   0.1    1.9  1  AAA_16        AAA ATPase domain
     0.0086   15.8   0.0      0.023   14.4   0.0    1.7  2  AAA_15        AAA ATPase domain
  ------ inclusion threshold ------
       0.01   15.5   0.1       0.16   11.6   0.0    2.6  2  AAA_30        AAA domain
      0.017   15.0   0.0      0.041   13.8   0.0    1.6  1  RsgA_GTPase   RsgA GTPase
      0.034   14.6   0.5        1.4    9.3   0.5    2.8  1  AAA           ATPase family associated with various cellular 
      0.047   12.5   0.4      0.099   11.4   0.0    1.6  2  ABC_ATPase    Predicted ATPase of the ABC class
      0.065   13.5   0.2       0.45   10.8   0.1    2.4  2  AAA_22        AAA domain
      0.097   12.8   0.3          1    9.5   0.1    2.4  2  AAA_33        AAA domain
       0.12   12.1   0.1        2.7    7.7   0.0    2.3  2  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
       0.13   11.8   0.0       0.27   10.7   0.0    1.4  1  AAA_7         P-loop containing dynein motor region


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  180.2  17.6   4.9e-56   6.3e-53       2     266 ..      94     359 ..      90     369 .. 0.90

  Alignments for each domain:
  == domain 1  score: 180.2 bits;  conditional E-value: 4.9e-56
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSS.TCCHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHH CS
  ABC_membrane   2 iliillailagvlsplfplvlgrildtlldk.gdpet...ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdt 94 
                   +++++ a  agv+ + f ++lg ++++l +  +d+      ++n ++  +++++l+ +i++++ +++++ ++e +s++lr+k+f+++  q+m+ffd 
    EFC39047.1  94 FFATVGAGGAGVIGLCFQFILGDLINSLATImSDS-NalrDEVNSIAGKFAIVALGAVIANFMNQFFNTLASETISRTLRQKYFESLTAQEMAFFDI 189
                   34444455566666667777777777666655333.24777******************************************************** PP

                   SCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHH CS
  ABC_membrane  95 nsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgir 191
                   ++vG+l    ++dv+ +++++++k ++ffq ++++v+gli++f+++wk++lv+++++p+i++++  +++ +kkl+kk ++a++ as++a+E++s i+
    EFC39047.1 190 KKVGQLACISSDDVAIVQEIYTSKWSTFFQQVVQVVVGLILAFISSWKMSLVIISTSPIIFVLICGVSQGIKKLSKKTSEANEHASAIATEIVSSIK 286
                   ************************************************************************************************* PP

                   HHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHH CS
  ABC_membrane 192 tVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflsl 266
                   tV+++g+e++++ ++ + l++++k g+ k i++g+++ ++ + +   +ala+wfG+ l  +ge+s+g++  f ++
    EFC39047.1 287 TVRSMGGEPKERIRYRNDLKKVHKYGLFKSILQGFVFFVLSFTIWGTVALAFWFGGNLTVDGEISIGSM--FRVF 359
                   ********************************************************************5..4444 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.5   0.0   3.3e-35   4.2e-32       1     137 []     432     582 ..     432     582 .. 0.90

  Alignments for each domain:
  == domain 1  score: 111.5 bits;  conditional E-value: 3.3e-35
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.................HHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................xxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.................esd 82 
                 lk  sl++k g+ va+vG++G+GKSt++ l+ + ++p +G+i +dg d++e +  +l++ +g++ qep+lf  + +r+n                 ++ 
  EFC39047.1 432 LKSFSLEIKTGQAVAFVGPSGSGKSTIVGLIERFYNPVKGNISIDGVDISELDPMWLHQVVGIVNQEPTLFACS-IRDNityacrrpvsqeeveeaAKA 529
                 6889********************************************************************99.************766555444444 PP

                 TCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  83 eeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                 ++++ ++s l   +  +t +++++ sLSgGqkqr+a+arall++pk+lllDE+t+
  EFC39047.1 530 ANCHSFISDLPEGY--TTLLGEKGVSLSGGQKQRIAIARALLQDPKILLLDEATS 582
                 44666666666555..99999999*****************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   1.7   1.9e-07   0.00025     135     211 ..     538     624 ..     430     631 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.9e-07
                 T..............CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEEEE CS
                 x..............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 135 e..............lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreemlekadklvgv 211
                 +              +LSgG+k+ +a+a        +   + llDe  +aLD +  + v   l++  k    i+i++r  +++++d l+ +
  EFC39047.1 538 DlpegyttllgekgvSLSGGQKQRIAIARA----LLQDPKILLLDEATSALDTESETLVQAALDKLMKGRTTICIAHRLSTVKNSDMLCVL 624
                 0333334444444447******99888754....345556899*****************************************9998755 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       9.8   1.3e+04       6      19 ..     211     224 ..     207     229 .. 0.74
   2 !   17.4   0.2   2.2e-06    0.0028      16      39 ..     436     459 ..     429     465 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 9.8
      AAA_29   6 lvNWgtfdghtiei 19 
                    W tf ++++++
  EFC39047.1 211 TSKWSTFFQQVVQV 224
                 56799999988776 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 2.2e-06
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                 ++ei++ +a+ ++GpsGsGKST++
  EFC39047.1 436 SLEIKTGQAVAFVGPSGSGKSTIV 459
                 567776669*************98 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.1   8.1e-06      0.01      24     160 ..     442     597 ..     431     608 .. 0.59

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 8.1e-06
      AAA_16  24 pelvllsGesGvGKsslv...rellralekdggiflrgkcdqlesaipysa.laqalareellrqllde.........aesaeleawrekleeala... 106
                 +++v ++G+sG+GKs++v   ++++++++++    ++ + ++     ++++ ++ +    ++++q+ +          + ++ ++  +e+ eea++   
  EFC39047.1 442 GQAVAFVGPSGSGKSTIVgliERFYNPVKGN----ISIDGVDI---SELDPmWLHQV-V-GIVNQEPTLfacsirdniTYACRRPVSQEEVEEAAKaan 531
                 47899*************6666666677777....77777777...45555555555.3.566666655555555555333333333333333333444 PP

      AAA_16 107 ..................avpelagaeasrllellkrllallsrderplvlvlDdlq.wadeaslqllaaLlr 160
                                    + +l+g +++r++ +  r+l      ++p +l+lD++   +d++s +l +a l+
  EFC39047.1 532 chsfisdlpegyttllgeKGVSLSGGQKQRIAIA--RAL-----LQDPKILLLDEATsALDTESETLVQAALD 597
                 4445555555655655444444444444444433..333.....25577888888885666677777777666 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.6   4.6e+03     246     275 ..     260     289 ..     253     306 .. 0.70
   2 !   14.4   0.0   1.8e-05     0.023      15      50 ..     433     469 ..     431     526 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.6
      AAA_15 246 qeklkeidkklaeelkkilkkkidkikkfn 275
                  +kl+++ ++ +e+++ i ++++++ik + 
  EFC39047.1 260 IKKLSKKTSEANEHASAIATEIVSSIKTVR 289
                 567888888888888877777777776544 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.8e-05
      AAA_15  15 kdveidlsee.ltvliGkNnsGKSsilealdlFlnnk 50 
                 k+++++++      ++G+ +sGKS+i+ +++ F n  
  EFC39047.1 433 KSFSLEIKTGqAVAFVGPSGSGKSTIVGLIERFYNPV 469
                 6677777776699********************9965 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.73   9.3e+02      43      96 ..     136     208 ..     123     220 .. 0.71
   2 ?   11.6   0.0   0.00013      0.16      19     114 ..     443     597 ..     436     609 .. 0.66

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.73
      AAA_30  43 eaaggrviglAptgkaAkvLaeelgi.eastiakllkrlk..................grarlepgtllivDE 96 
                 ++  g+ +++A  +  A+ +++ +++ +++ti + l++                    + a ++++++ iv E
  EFC39047.1 136 NSIAGKFAIVALGAVIANFMNQFFNTlASETISRTLRQKYfesltaqemaffdikkvgQLACISSDDVAIVQE 208
                 4445788899999999999998887449999999996555777777777777777664334444446666666 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00013
      AAA_30  19 rvavltGpAGtGKttalkalreaweaa.g...................................grviglAptgkaAkv.Laeelgieastiakllkrl 80 
                 + ++ +Gp G+GK+t+++ +++ ++   g                                   ++ i +A    ++++ +  e  ++a++ +++++ l
  EFC39047.1 443 QAVAFVGPSGSGKSTIVGLIERFYNPVkGnisidgvdiseldpmwlhqvvgivnqeptlfacsiRDNITYACRRPVSQEeV--EEAAKAANCHSFISDL 539
                 478899****************99988457888888888888877744444444333333333322222222222222212..2335778888888777 PP

      AAA_30  81 k........................grarlepgtllivDEagmvdtkqlaallkaaek 114
                                          +ra l++ ++l+ DEa  +  ++ ++l++aa +
  EFC39047.1 540 PegyttllgekgvslsggqkqriaiARALLQDPKILLLDEATSALDTESETLVQAALD 597
                 7888888888888888888888887666777778888888888777777777777655 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   3.2e-05     0.041      84     119 ..     426     462 ..     401     476 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 3.2e-05
                  TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHH CS
  RsgA_GTPase  84 aktkegleelkellkd.ktsvlvGqSGvGKStLinal 119
                    +++ l++ + ++k  + +++vG+SG GKSt++  +
   EFC39047.1 426 RPNTTVLKSFSLEIKTgQAVAFVGPSGSGKSTIVGLI 462
                  5555666666667776699*************99776 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.5    0.0011       1.4       2      98 ..     446     605 ..     445     623 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0011
                 EEESSTTSSHHHHHHHHHHHHT..HEEEEEETTTCSSS............................................................. CS
         AAA   2 llyGppGtGKTllakavakelg..vefleisgsellsk............................................................. 37 
                  ++Gp G GK++++  + +  +     ++i+g ++  +                                                             
  EFC39047.1 446 AFVGPSGSGKSTIVGLIERFYNpvKGNISIDGVDIS-Eldpmwlhqvvgivnqeptlfacsirdnityacrrpvsqeeveeaakaanchsfisdlpegy 543
                 578888888888888887776442112333333333.22344666666666666666666666666667777777777777777777777777788888 PP

                 ........STTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  38 ........yvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkk 98 
                         +   + +k r  +++a  + +p+il++DE+ +   ++      +e+ v+++L + ++g ++
  EFC39047.1 544 ttllgekgVSLSGGQKQRIAIARALLQ-DPKILLLDEATSALDTE------SETLVQAALDKLMKGRTT 605
                 886666654444555555555555444.599******99999999......677777777777777665 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       2.1   2.7e+03     242     266 ..     439     464 ..     437     471 .. 0.74
   2 ?   11.4   0.0   7.7e-05     0.099     298     353 ..     528     584 ..     518     615 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.1
                 E-SS.EEEEEE-TTSSHHHHHHHHHH CS
  ABC_ATPase 242 ipkG.vtlIvGggfhGKsTLLeAlek 266
                 i++G  ++ vG+   GKsT++  +e+
  EFC39047.1 439 IKTGqAVAFVGPSGSGKSTIVGLIER 464
                 677766778999999****9877765 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 7.7e-05
                 EEE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS-H CS
  ABC_ATPase 298 kgvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsAt 353
                 k ++  +Fi++LPeg +t         SG   q  +i++al  + k+lL+DE tsA 
  EFC39047.1 528 KAANCHSFISDLPEGYTTLlGEKGVSLSGGQKQRIAIARALLQDPKILLLDEATSAL 584
                 5678899**********9955566678****************************95 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       4.9   6.3e+03      55      68 ..     170     183 ..     156     224 .. 0.50
   2 ?   10.8   0.1   0.00035      0.45       4     103 ..     441     584 ..     437     608 .. 0.61

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 4.9
      AAA_22  55 dllrellralglel 68 
                 +l+++ ++ l+ + 
  EFC39047.1 170 TLRQKYFESLTAQE 183
                 44444444444332 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00035
      AAA_22   4 tagilvvtGesGtGKTtllrrlleqldeeakaee.........................................erpevvfvtlpsst.sskdllrel 60 
                 t + ++ +G+sG+GK+t +  + + ++ ++                                             +++++ +v+ +++  +  ++ ++l
  EFC39047.1 441 TGQAVAFVGPSGSGKSTIVGLIERFYNPVKGNISidgvdiseldpmwlhqvvgivnqeptlfacsirdnityacrRPVSQEEVEEAAKAaNCHSFISDL 539
                 7788999**********9988888886655444466677777777777766666666666666666666665444334444555555555666666666 PP

      AAA_22  61 lralglelkaerlsseell.ealeqalrarav...ielliiDEaqh.l 103
                  + ++  l +   +   l   + ++ + ara    +++l++DEa   l
  EFC39047.1 540 PEGYTTLLGE---KGVSLSgGQKQRIAIARALlqdPKILLLDEATSaL 584
                 6666655555...22222224444444444444555566667666655 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.68   8.7e+02      12      63 ..     266     317 ..     264     320 .. 0.88
   2 ?    9.5   0.1   0.00079         1       2      16 ..     445     459 ..     445     464 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.68
      AAA_33  12 Kstlaerllkklgavllssdtlrrrlfgtdqqsktdytrvldrlyqilnela 63 
                 K+  a +++ + +++++ss +  r + g+ ++++++++++++  ++ l++ +
  EFC39047.1 266 KTSEANEHASAIATEIVSSIKTVRSMGGEPKERIRYRNDLKKVHKYGLFKSI 317
                 8999999999999*********************999999998888877665 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00079
      AAA_33   2 vllvGlpGsGKstla 16 
                 v +vG++GsGKst +
  EFC39047.1 445 VAFVGPSGSGKSTIV 459
                 679**********86 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.0    0.0021       2.7       3      22 ..     446     465 ..     445     485 .. 0.80
   2 ?    1.6   0.0      0.15   1.9e+02     236     271 ..     553     585 ..     549     605 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0021
      AAA_21   3 vliGpNgsGKSnLLdaldll 22 
                 +++Gp gsGKS++  +++ +
  EFC39047.1 446 AFVGPSGSGKSTIVGLIERF 465
                 68***********9999766 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.15
      AAA_21 236 elSdGtkrllalltallralkkgsllliDEpEngLH 271
                 +lS G+k+ +a++ all+++   ++ll+DE  + L+
  EFC39047.1 553 SLSGGQKQRIAIARALLQDP---KILLLDEATSALD 585
                 68999999999999999999...9******777766 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00021      0.27      26      50 ..     435     459 ..     417     472 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00021
       AAA_7  26 lelllknkkpvllvGptGtGKtvii 50 
                 ++l +k ++ v +vGp+G+GK++i+
  EFC39047.1 435 FSLEIKTGQAVAFVGPSGSGKSTIV 459
                 45668999***************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (658 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1191  (0.0664287); expected 358.6 (0.02)
Passed bias filter:                      755  (0.0421105); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.85u 0.35s 00:00:01.20 Elapsed: 00:00:00.55
# Mc/sec: 3571.10
//
Query:       EFC39048.1  [L=106]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0023   17.4   0.4     0.0029   17.1   0.4    1.0  1  DUF5131   Protein of unknown function (DUF5131)


Domain annotation for each model (and alignments):
>> DUF5131  Protein of unknown function (DUF5131)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.4   1.6e-07    0.0029      82     158 ..      19     101 ..      16     105 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 1.6e-07
     DUF5131  82 DlfhekvpdefidrvfaviaatpqhtflvlTKrpermrellkeaaeear.......vpenvwlGvsvenqkeaderiekLlavp 158
                 D+ +++v++e++d+  ++  +++++ fl+ T r+e ++++ +++ ++           +n+w+   ++++ + ++ iekL +++
  EFC39048.1  19 DIIQKEVQEEIMDSSTEITISNDKKLFLI-TTRIEWLMAMERKDDQQISyyeekfnEVANIWFSLPIVDEVKNETSIEKLEQLK 101
                 89999*******99999999999888877.5578888777777666655677765444**********************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (106 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       722  (0.04027); expected 358.6 (0.02)
Passed bias filter:                      264  (0.0147247); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.34s 00:00:00.87 Elapsed: 00:00:00.55
# Mc/sec: 575.29
//
Query:       EFC39049.1  [L=130]
Description: hypothetical protein NAEGRDRAFT_81388 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00016   21.4   0.2    0.00024   20.8   0.2    1.3  1  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom
  ------ inclusion threshold ------
       0.11   12.4   0.0       0.14   12.1   0.0    1.1  1  AAA_31    AAA domain


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.2   2.7e-08   0.00024       3      62 ..      29      87 ..      27      93 .. 0.90

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 2.7e-08
                EESETTTSSHHHHHHHHHT.TSCEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHHHHTTE CS
       RRM_1  3 VgnLppdvteeeLkelFsk.fGpiksiklvrdetgkskgfafVeFeskedAekAlealngk 62
                V  Lp+ v+e+++  +F+k  G++k+++++r +       afVeF+++   +kA+e l +k
  EFC39049.1 29 VLELPFVVDEQQVGNFFKKcDGGVKRLEIIR-SGALVFSAAFVEFNKQKGKKKAIE-LSEK 87
                5679***************77**********.7999999****************9.7665 PP

>> AAA_31  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   1.5e-05      0.14      41     123 ..       2      97 ..       1     104 [. 0.66

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.5e-05
      AAA_31  41 Qanattglgiekne.......iektlyevl....ieeknikeaiiktk..venldlipssid.LaeaeielvelekkeeilkellekvkdeYDyiii 123
                 Q+n+++  +  ++e       +++t++ +     ++e+++ +  +k +  v++l++i s    +++a +e+ + + k +   el ekv +eYD+ii+
  EFC39049.1   2 QNNTSMMKQRLNEEkdkdpefLKRTICVLElpfvVDEQQVGNFFKKCDggVKRLEIIRSGALvFSAAFVEFNKQKGK-KKAIELSEKVGQEYDVIIL 97 
                 888888665533332344444333444442445369999999999887778999***99877245555566555555.4558999***********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       680  (0.0379274); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.33s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 765.69
//
Query:       EFC39050.1  [L=368]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.2e-44  150.4   0.0    8.1e-44  150.0   0.0    1.1  1  Abhydrolase_3    alpha/beta hydrolase fold
    1.3e-13   50.7   0.2    8.3e-13   48.0   0.2    2.0  1  COesterase       Carboxylesterase family
    8.4e-07   28.2   0.2    2.4e-06   26.7   0.1    1.6  1  Say1_Mug180      Steryl acetyl hydrolase
    7.7e-06   25.0   0.0    1.2e-05   24.3   0.0    1.2  1  Chlorophyllase2  Chlorophyllase enzyme
    1.6e-05   24.1   0.0    2.7e-05   23.3   0.0    1.3  1  Chlorophyllase   Chlorophyllase
  ------ inclusion threshold ------
      0.036   12.6   0.0      0.063   11.8   0.0    1.3  1  PAF-AH_p_II      Platelet-activating factor acetylhydrolase, 
       0.14   11.8   0.0         14    5.2   0.0    2.2  2  Esterase         Putative esterase


Domain annotation for each model (and alignments):
>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  150.0   0.0   3.2e-47   8.1e-44       1     210 [.     116     344 ..     116     345 .. 0.91

  Alignments for each domain:
  == domain 1  score: 150.0 bits;  conditional E-value: 3.2e-47
                    EEEE--STTTS--TTTTHHHHHHHHHHHTSEEEEEE---TTTS-TTHHHHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHHHHHHHHHHHHHTT CS
  Abhydrolase_3   1 lvyfHGGGfvlgsldthdalcrelakelgavvvsvdYrlAPehpfPaavedalaalrwlaeqawelgadpsrivlaGdSaGGnlaaavalrardeg 96 
                    ++y+HGGG+++g++d +++lc+ la++ g +vvs+dYr+ Peh fP  ++d l+al+w+  + ++++ + +++++ GdSaGG+la  + +r+ + +
     EFC39050.1 116 VMYIHGGGWMFGNIDISNRLCEGLANK-GFIVVSIDYRRTPEHIFPSCLNDNLNALSWIGRNYEKYNGNINQLIISGDSAGGHLAITTQIRLFSIQ 210
                    69***********************96.9*********************************99************************98877664 PP

                    ---........EEEEEEESE-SSTSSTTSHHHHHCHHT.TTSSSSCHHHHHHHHHHHSS...GGGGG.STTTSGGGC...S-...SST---EEEEE CS
  Abhydrolase_3  97 epk........vagqvliyPvtdlertesesikkaeel.adgplltraaldlfwrlylp...eadrd.dplasplla...ed...lsglpptlvvv 173
                    +          v++q+l+yPv d++r   e++++  ++ ++g ++  a +d+fwr +++   e++++ +pl+sp+ +   +d    s++p+ ++  
     EFC39050.1 211 KKLleresipsVTHQALLYPVADFYRYGDEKYESYMKYrDNGLIIDGAVMDMFWRNFIGnntEEQVKsNPLISPVSGlilSDkvlYSQFPKGFIWL 306
                    33357899999*************9999999999999978888899************446766666699*****9987655798999******** PP

                    ETT-TTHHHHHHHHHHHH.HTT--EEEEEETTEETTGG CS
  Abhydrolase_3 174 aefDplrdegeayaerlr.aagvevelieyegmvHgfa 210
                    ae+D+l+deg+ +a++++ a  ++ +++e++  vHgf+
     EFC39050.1 307 AEYDVLKDEGKSFANAVNnASPNKLKVKEWKSCVHGFI 344
                    *****************9567899*************7 PP

>> COesterase  Carboxylesterase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.0   0.2   3.2e-16   8.3e-13      90     199 ..     100     199 ..      98     220 .. 0.87

  Alignments for each domain:
  == domain 1  score: 48.0 bits;  conditional E-value: 3.2e-16
                 EEEEEESSSSSTTSSEEEEEEE--STTTS-BG..CGS-THHHHHHHTSEEEEE----HHHHH-B-SSTTSBS-HHHHHHHHHHHHHHHHGGGGTEEEEE CS
  COesterase  90 LnvytPkekkeakkklPVlVwihGggfqtgsa..seydgsaLaaegnvivVtinYRlGvlGFlstgdeeapGNvGllDqvlALrWVkenIasFGGdper 186
                 L vy+Pk  ++++ ++P++++ihGgg ++g    s+  ++ La++ + ivV+i YR  +   +            l D   AL W+ +n ++++G+ ++
  EFC39050.1 100 LRVYQPK--QNRDGGYPIVMYIHGGGWMFGNIdiSNRLCEGLANK-GFIVVSIDYRRTPEHIFPS---------CLNDNLNALSWIGRNYEKYNGNINQ 186
                 78****8..6789999**************985466889******.**********776554444.........799********************** PP

                 EEEEEETHHHHHH CS
  COesterase 187 vtlfGesAGaasv 199
                   + G+sAG+ ++
  EFC39050.1 187 LIISGDSAGGHLA 199
                 *********9875 PP

>> Say1_Mug180  Steryl acetyl hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.1   9.2e-10   2.4e-06     114     332 ..     105     329 ..      82     339 .. 0.69

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 9.2e-10
  Say1_Mug180 114 petfdPkvDpvllylHGGgfalklipvtlvfLsnlrklfpdmailvsDYtvtaakdqskkYplqvleslavydyl....vkskg.fknvvvlGdSaGG 206
                  p++   +  p+++y+HGGg++++ i ++    + l ++     ++  DY  t      + +p  + ++l+   ++    +k  g ++++++ GdSaGG
   EFC39050.1 105 PKQNRDGGYPIVMYIHGGGWMFGNIDISNRLCEGLANK--GFIVVSIDYRRTP----EHIFPSCLNDNLNALSWIgrnyEKYNGnINQLIISGDSAGG 196
                  666555666***************99987777776654..2344446**9998....66788888888888776622113334426778999****** PP

  Say1_Mug180 207 nlvLslllklsklnkvvlPkkai.......aiSPWlnltil.dekekeylkasdklDvlclkglelfgklyvnnrepeeelktdefvnieknfdievW 296
                   l ++  ++l  ++k++l ++ i       ++ P ++     dek   y+k  d+   +   ++++f + +++n ++ee++k++++++       +  
   EFC39050.1 197 HLAITTQIRLFSIQKKLLERESIpsvthqaLLYPVADFYRYgDEKYESYMKYRDNGLIIDGAVMDMFWRNFIGN-NTEEQVKSNPLISPVSGLILS-- 291
                  **99988887777766666665522222226889999876615555667888888778888899**********.999999999999855533322.. PP

  Say1_Mug180 297 sei..lekckllityGddEilkdqikllidkiselkek 332
                  +++   +  k +i   + ++lkd+ k++++ + +++++
   EFC39050.1 292 DKVlySQFPKGFIWLAEYDVLKDEGKSFANAVNNASPN 329
                  33311344566777777777777777777777766665 PP

>> Chlorophyllase2  Chlorophyllase enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   0.0   4.9e-09   1.2e-05       6     109 ..     100     204 ..      96     232 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 4.9e-09
  Chlorophyllase2   6 llvvaPtea..geYpvllflhGyl...llnslYsqlLkhiashgfivvapqlykvaeada.keiksaakvlnWlakgLesvlpeevepdlskla 93 
                      l v++P+++  g Yp+++++hG      + ++ ++l + +a  gfivv+    ++ e+   + ++   + l W+ ++ e     + + ++++l 
       EFC39050.1 100 LRVYQPKQNrdGGYPIVMYIHGGGwmfGNIDISNRLCEGLANKGFIVVSIDYRRTPEHIFpSCLNDNLNALSWIGRNYE-----KYNGNINQLI 188
                      6789998643389********8654333456788999*************988877776678999***********998.....899******* PP

  Chlorophyllase2  94 lsgHSrGgktafalal 109
                      +sg S+Gg+ a+   +
       EFC39050.1 189 ISGDSAGGHLAITTQI 204
                      *********9987655 PP

>> Chlorophyllase  Chlorophyllase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   0.0   1.1e-08   2.7e-05      25     139 ..      90     204 ..      67     221 .. 0.78

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 1.1e-08
  Chlorophyllase  25 srsspapPkpliivtPae..aGtypvvlflhG..tllsnkfysk.llnhiashGfivvaPqlykllp.PsaqdeidsaaevieWlseglkavlpt 113
                     +  +p +  +l++  P++  +G yp+v+++hG  +++ n + s+ l + +a  Gfivv+    +  p       +++  + + W+ ++ +     
      EFC39050.1  90 EVGEPVAKYALRVYQPKQnrDGGYPIVMYIHGggWMFGNIDISNrLCEGLANKGFIVVSIDYRR-TPeHIFPSCLNDNLNALSWIGRNYE----- 178
                     455666777899999986336**********644899***999637789*********988555.442444456788888999**99976..... PP

  Chlorophyllase 114 sveanlsklalvGhsrGGktafalal 139
                     + ++n+++l ++G s GG+ a +  +
      EFC39050.1 179 KYNGNINQLIISGDSAGGHLAITTQI 204
                     5699**************99987665 PP

>> PAF-AH_p_II  Platelet-activating factor acetylhydrolase, isoform II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   2.4e-05     0.063      97     136 ..     110     152 ..      81     170 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.4e-05
                  SS-EEEEEEE--TT...--TTTTHHHHHHHHHTT-EEEEE--- CS
  PAF-AH_p_II  97 kekyPlivFsHGLg...afRtlYsalcielAskGfvvaavEHr 136
                  ++ yP++++ HG g   +   +   lc  lA kGf+v++++ r
   EFC39050.1 110 DGGYPIVMYIHGGGwmfGNIDISNRLCEGLANKGFIVVSIDYR 152
                  256*********7643356677889*************99988 PP

>> Esterase  Putative esterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.0    0.0056        14       8      37 ..      98     125 ..      94     153 .. 0.75
   2 ?    4.2   0.0     0.011        29     104     132 ..     171     202 ..     164     207 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0056
                 EEEEEEE.CC.GGTTTEEEEEEE--TTHHC CS
    Esterase   8 ikvqvyLPedyspgrkypvvylldGltgwd 37 
                 + ++vy P++ ++ ++yp v++ +G  gw 
  EFC39050.1  98 YALRVYQPKQ-NRDGGYPIVMYIHG-GGWM 125
                 6789******.**************.8883 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.011
                 HHHHHHCSEECCC...EEEEEETHHHHHHHHH CS
    Esterase 104 plldanfrtapdg...ravaGqSmGGlgALil 132
                 +++  n++++        + G+S GG+ A+++
  EFC39050.1 171 SWIGRNYEKYNGNinqLIISGDSAGGHLAITT 202
                 67777777777777777899*********987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (368 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       484  (0.0269954); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.38s 00:00:01.03 Elapsed: 00:00:00.56
# Mc/sec: 1966.70
//
Query:       EFC39051.1  [L=1736]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.7e-06   27.2   2.4      0.043   14.1   0.0    4.4  4  HEAT           HEAT repeat
    1.1e-05   25.8   0.2       0.11   12.9   0.2    3.8  3  HEAT_2         HEAT repeats
  ------ inclusion threshold ------
       0.11   13.1   9.1       0.47   11.1   0.2    5.4  6  Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
       0.15   11.4   7.8       0.79    9.1   7.8    2.3  1  UPF0524        UPF0524 of C3orf70
       0.27   11.4   5.0        0.5   10.6   0.4    3.9  3  RTP1_C1        Required for nuclear transport of RNA pol II C
        0.3   11.4   2.4        7.1    7.0   0.0    3.3  3  Cohesin_HEAT   HEAT repeat associated with sister chromatid c
        2.6    8.8   5.3        1.7    9.4   0.1    3.7  3  Zn_ribbon_2    Putative zinc ribbon domain


Domain annotation for each model (and alignments):
>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.0   1.7e-05     0.043       1      29 [.     353     381 ..     353     382 .. 0.92
   2 ?   -2.2   0.0       2.9   7.4e+03       5      17 ..     399     411 ..     398     412 .. 0.85
   3 !    9.7   0.0   0.00044       1.1       5      28 ..     436     459 ..     432     460 .. 0.90
   4 ?   -1.9   0.1       2.2   5.7e+03       2      12 ..     606     618 ..     606     622 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.7e-05
                 HHHHHHHHHT-SSHHHHHHHHHHHHHHHH CS
        HEAT   1 llPlllkllsDpspeVReaAakaLgalae 29 
                 ++P l+  l+D++ +VR+a+++ Lg++ +
  EFC39051.1 353 VIPNLCIQLKDEEVQVRSAVIQLLGNMFK 381
                 58999999*****************9865 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2.9
                 HHHHHT-SSHHHH CS
        HEAT   5 llkllsDpspeVR 17 
                 +l+  +D++ +VR
  EFC39051.1 399 FLSRFTDKDNRVR 411
                 567789******9 PP

  == domain 3  score: 9.7 bits;  conditional E-value: 0.00044
                 HHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   5 llkllsDpspeVReaAakaLgala 28 
                 l + ++Dp+ +VR+++++++ ++a
  EFC39051.1 436 LEERIMDPDEKVRRNVVETIINIA 459
                 788899**************9997 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 2.2
                 HHHHHHHHT-..S CS
        HEAT   2 lPlllkllsD..p 12 
                 lPl+l++ls+  p
  EFC39051.1 606 LPLILNNLSSslP 618
                 8*******87454 PP

>> HEAT_2  HEAT repeats
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0023       5.8       2      32 ..     355     385 ..     354     438 .. 0.63
   2 !   12.9   0.2   4.2e-05      0.11       4      67 ..     436     505 ..     430     512 .. 0.72
   3 ?   -0.1   0.0      0.48   1.2e+03      33      56 ..     738     762 ..     727     778 .. 0.62

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0023
      HEAT_2   2 daLlqalendpdpevrraairaLg.rignpea 32 
                 + L+ +l +d++ +vr a+i+ Lg  ++ +e+
  EFC39051.1 355 PNLCIQL-KDEEVQVRSAVIQLLGnMFKAKES 385
                 7789999.9***************52344333 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 4.2e-05
      HEAT_2   4 LlqalendpdpevrraairaLgrignp.......ealpaLvellededpavRraaaeaLgaigdpealpaL 67 
                 L +++  dpd++vrr++++++ +i+ +       ++++ L e  +d+++  R +a e  +++ ++ a +aL
  EFC39051.1 436 LEERI-MDPDEKVRRNVVETIINIAMEspalvsdSLMQKLKERTRDKKAVLRLHALELCAKLYNHHATEAL 505
                 44455.58888888888888886665544555556688888888888888888888888888777777776 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.48
      HEAT_2  33 lpaLvell.ededpavRraaaeaLg 56 
                 +p L+el  + +d +    + +aL+
  EFC39051.1 738 IPSLIELFeKEQDYDLNILVLKALS 762
                 4444444433344444444444444 PP

>> Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.94   2.4e+03      34      58 ..     121     145 ..     109     165 .. 0.79
   2 ?   -2.8   0.0       4.1     1e+04      69      82 ..     209     222 ..     204     249 .. 0.74
   3 ?   11.1   0.2   0.00019      0.47      23      85 ..     348     411 ..     337     424 .. 0.87
   4 ?    2.7   0.0     0.074   1.9e+02      34      60 ..     438     464 ..     420     479 .. 0.80
   5 ?   -3.3   0.0       5.5   1.4e+04      22      42 ..     585     605 ..     579     606 .. 0.82
   6 ?   -3.9   0.1         7   1.8e+04      48      76 ..    1391    1419 ..    1381    1426 .. 0.66

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.94
  Vac14_Fab1_bd  34 kcfsDkdsrvRyyacEslyniakva 58 
                    k++s k ++vR ya+ s+  i +v+
     EFC39051.1 121 KIISNKTEEVRVYAACSIVDILRVT 145
                    457889999******9999999986 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 4.1
  Vac14_Fab1_bd  69 ifdalvklvaDsde 82 
                    +f+ l+++v+Ds++
     EFC39051.1 209 LFQSLFRIVTDSES 222
                    67777777777764 PP

  == domain 3  score: 11.1 bits;  conditional E-value: 0.00019
  Vac14_Fab1_bd  23 eyleeivkpvlkcfsDkdsrvRyyacEslyniakvakgevlkllneifda.lvklvaDsdesvk 85 
                    + l ++++ +   ++D++ +vR  ++  l n+ k+ ++e++k   +if++ + + ++D+d+ v+
     EFC39051.1 348 RLLLTVIPNLCIQLKDEEVQVRSAVIQLLGNMFKAKESELFKEYPNIFETdFLSRFTDKDNRVR 411
                    5666788999999***********************************864567799**99998 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.074
  Vac14_Fab1_bd  34 kcfsDkdsrvRyyacEslyniakvakg 60 
                    + + D d++vR  ++E++ nia  +  
     EFC39051.1 438 ERIMDPDEKVRRNVVETIINIAMESPA 464
                    4689*****************976655 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 5.5
  Vac14_Fab1_bd  22 keyleeivkpvlkcfsDkdsr 42 
                    k+ l+++v+++++  +D+dsr
     EFC39051.1 585 KKSLQHFVNTLIHLEEDDDSR 605
                    567889999999999999988 PP

  == domain 6  score: -3.9 bits;  conditional E-value: 7
  Vac14_Fab1_bd   48 cEslyniakvakgevlkllneifdalvkl 76  
                     +E +  ++ ++++ev+++l ++ +  v+ 
     EFC39051.1 1391 SEKMNELCAMMRTEVMNNLFDLKKRNVQR 1419
                     46677777777777777777665555555 PP

>> UPF0524  UPF0524 of C3orf70
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   7.8   0.00031      0.79     112     218 ..    1195    1302 ..    1175    1321 .. 0.60

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00031
     UPF0524  112 isdlfiddyvvkringkmcyvqrpapkveeakkeeaekkeaavkq....lkkekvkgpkldhcsspsssedsginalglhylescdeeeeeddelss 204 
                  i  lf+ d    ++n k+    +p  k ++++k +++k+++ +++    ++k+k++     + s ps s  +    +  +  es +eeeee++e s+
  EFC39051.1 1195 IKTLFLPDGF--KLNEKLARQVQPVEKKKKPTKVDEKKDKKRKRTttkkTTKKKKEEKESTKRSLPSRSAKTNRKKIESE-DESEEEEEEEEEEQSE 1288
                  5556665432..45666655444444444444444443333333311113333444444455566777766655555443.4677889999999999 PP

     UPF0524  205 dedsspeslweqde 218 
                   e++s +s  e++e
  EFC39051.1 1289 GEEQSEQSEEEEEE 1302
                  99999999887765 PP

>> RTP1_C1  Required for nuclear transport of RNA pol II C-terminus 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.4    0.0002       0.5       7      96 ..     360     487 ..     355     501 .. 0.83
   2 ?   -3.4   0.0       4.3   1.1e+04      70     104 ..     732     763 ..     716     769 .. 0.60
   3 ?   -1.5   0.1       1.1   2.8e+03      73     108 ..    1480    1513 ..    1474    1516 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.0002
     RTP1_C1   7 dlqdpllpvrahglvlLrkliekkske......................................avldiekilkllleaLkdedsYvYLnaikgLvaL 67 
                 +l+d+++ vr+  ++lL +++++k++e                                        ++ + + + l e + d+d+ v  n+++++ ++
  EFC39051.1 360 QLKDEEVQVRSAVIQLLGNMFKAKESElfkeypnifetdflsrftdkdnrvriymskfasgmiknHPSSNKVLNERLEERIMDPDEKVRRNVVETIINI 458
                 89***********************99*********************************9666333333333344445677***************** PP

     RTP1_C1  68 advfpeevlklLleeyeeenekeslderl 96 
                 a   p+ v + L+++ +e++++++   rl
  EFC39051.1 459 AMESPALVSDSLMQKLKERTRDKKAVLRL 487
                 ***************98877777666665 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 4.3
     RTP1_C1  70 vfpeevlklLleeyeeenekeslderlkvGEaLlr 104
                 ++ ++ ++ L+e +   +++++ d  + v  aL +
  EFC39051.1 732 AMGKDSIPSLIELF---EKEQDYDLNILVLKALSQ 763
                 34567888888888...555666666555555555 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1.1
     RTP1_C1   73 eevlklLleeyeeenekeslderlkvGEaLlrvirr 108 
                  ++ ++ +l+++  ++++++   +  +GE+Ll++ +r
  EFC39051.1 1480 KTLVRNILSKW--KEHSQEKKRKKNLGEMLLKTYKR 1513
                  56667777777..5566666677789*****99887 PP

>> Cohesin_HEAT  HEAT repeat associated with sister chromatid cohesion
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0    0.0028       7.1      27      42 .]     361     376 ..     360     376 .. 0.94
   2 ?   -2.9   0.1       3.4   8.8e+03      23      42 .]     436     455 ..     436     455 .. 0.87
   3 ?    2.4   0.1     0.076   1.9e+02      15      41 ..     466     492 ..     457     492 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0028
                   HHSS-HHHHHHHHHHH CS
  Cohesin_HEAT  27 ltDsspsVRdAaLell 42 
                   l D++++VR A+++ll
    EFC39051.1 361 LKDEEVQVRSAVIQLL 376
                   78************98 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.4
                   HHHHHHSS-HHHHHHHHHHH CS
  Cohesin_HEAT  23 iarrltDsspsVRdAaLell 42 
                   +++r  D++  VR  ++e++
    EFC39051.1 436 LEERIMDPDEKVRRNVVETI 455
                   58999***999999999987 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.076
                   GSHHHHHHHHHHHHSS-HHHHHHHHHH CS
  Cohesin_HEAT  15 sapevldtiarrltDsspsVRdAaLel 41 
                    ++++++ +++r +D +++ R  aLel
    EFC39051.1 466 VSDSLMQKLKERTRDKKAVLRLHALEL 492
                   56799**************99999987 PP

>> Zn_ribbon_2  Putative zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.2       4.2   1.1e+04      66      78 ..     675     687 ..     652     717 .. 0.61
   2 ?    9.4   0.1   0.00066       1.7      25      60 ..     893     928 ..     881     944 .. 0.83
   3 ?   -4.1   0.2         7   1.8e+04      48      62 ..    1387    1401 ..    1379    1415 .. 0.46

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 4.2
  Zn_ribbon_2  66 earkllkkllpkL 78 
                  e ++++k++++kL
   EFC39051.1 675 EEKDYMKTVIQKL 687
                  3344444444443 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00066
  Zn_ribbon_2  25 edYCkyCykdGeftepdltmeemiekcvkklaeenk 60 
                   dYC+ C k+G   e + t  ++++++ + l+++++
   EFC39051.1 893 VDYCIACTKEGITEESEATSSKLVNILFSILKNKGS 928
                  59*************************999999875 PP

  == domain 3  score: -4.1 bits;  conditional E-value: 7
  Zn_ribbon_2   48 iekcvkklaeenkel 62  
                   i+++ +k++e  + +
   EFC39051.1 1387 IQQLSEKMNELCAMM 1401
                   333333333333222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1736 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3139  (0.175079); expected 358.6 (0.02)
Passed bias filter:                      594  (0.0331307); expected 358.6 (0.02)
Passed Vit filter:                       262  (0.0146132); expected 17.9 (0.001)
Passed Fwd filter:                        63  (0.00351386); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.96u 0.37s 00:00:02.33 Elapsed: 00:00:00.61
# Mc/sec: 8589.78
//
Query:       EFC39052.1  [L=361]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.7e-27   93.8   0.1    1.2e-26   93.2   0.1    1.4  1  ADH_zinc_N       Zinc-binding dehydrogenase
    8.8e-13   49.5   0.0    1.5e-12   48.7   0.0    1.3  1  ADH_zinc_N_2     Zinc-binding dehydrogenase
    2.6e-07   30.5   0.8    1.5e-06   28.0   0.1    2.1  2  ADH_N            Alcohol dehydrogenase GroES-like domain
    0.00011   21.6   0.1    0.00017   21.0   0.1    1.2  1  AlaDh_PNT_C      Alanine dehydrogenase/PNT, C-terminal domain
     0.0036   17.0   0.3     0.0088   15.8   0.3    1.6  1  Eno-Rase_NADH_b  NAD(P)H binding domain of trans-2-enoyl-CoA 
  ------ inclusion threshold ------
      0.013   15.0   0.9      0.017   14.6   0.1    1.6  2  adh_short        short chain dehydrogenase
      0.015   15.1   0.1      0.024   14.3   0.1    1.3  1  ELFV_dehydrog    Glutamate/Leucine/Phenylalanine/Valine dehyd


Domain annotation for each model (and alignments):
>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.2   0.1   4.8e-30   1.2e-26       1     126 [.     175     302 ..     175     314 .. 0.91

  Alignments for each domain:
  == domain 1  score: 93.2 bits;  conditional E-value: 4.8e-30
                 HHHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTT.ESEEEET.TTC.HHHHHHHHHTTTSSEEEEEESSCSHHHHHHHHHCEEEEEEEEECSCTSSEEE CS
  ADH_zinc_N   1 gvGlaavqlAkalGaeviavdsseeklelakklG.adeviny.kea.dlverikeltggegvdvvfecvGsgatleaalkllkpgGrlvvvGggkgeee 96 
                 gvGlaavq+Ak lGa via++ss+ek++++ + G ad+v+ny +++ d+ +++ e+t+g+g d++++ vG g+   ++lk+++ gG l v+G+ +  ++
  EFC39052.1 175 GVGLAAVQIAKSLGAIVIAACSSDEKCKICTEKGqADFVVNYsSNKkDWFKQVLEFTKGKGCDIIYDPVG-GDLALQSLKCIAWGGSLIVIGFASSIQQ 272
                 9*****************************************944459**********************.**********************999999 PP

                 EEHHHHHHTT-EEEEE-SSCHHHHHHHHHH CS
  ADH_zinc_N  97 fdlrnlllkeksilGsllgslreefkeald 126
                 ++++ ll k+++ +G+ +gs+ +  +++++
  EFC39052.1 273 IPANILLVKNVRATGCYWGSYMKHEPQVIQ 302
                 ********************5544444444 PP

>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.7   0.0   5.7e-16   1.5e-12       3     133 .]     210     348 ..     209     348 .. 0.84

  Alignments for each domain:
  == domain 1  score: 48.7 bits;  conditional E-value: 5.7e-16
                   -SEEEETT...STTHH...HHH-TT-EEEEEES-HHHHH.HHHHHHEEEEEEEEE--.--....S-EEE-CHHHCTTT-EEEE--GGG...-..-HH CS
  ADH_zinc_N_2   3 Adevidyr...tedfe...aatggegvDvvldtvggealleaslkvlpggGrlvsig.gpp...lsaallkpakkrkgrsvkyeflfsmkas.aqad 88 
                   Ad v++y    ++ f+   + t+g+g D+++d vgg+ +  +slk+++ gG l++ig +++   ++a++l +++  +  + ++  +++ +++ + ++
    EFC39052.1 210 ADFVVNYSsnkKDWFKqvlEFTKGKGCDIIYDPVGGDLA-LQSLKCIAWGGSLIVIGfASSiqqIPANILLVKN-VRATGCYWGSYMKHEPQvI-QQ 303
                   899995543314555588888899************988.9******888*******65559998888888877.5577899999998888855.55 PP

                   HHHHHHHHHHHHH----EEEEEEGGGHHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  89 ileelaalieeGklrpvvdrvfpleeaaeAhrylesgrarGKiVl 133
                    +++l++++ ++++ p v++ +p+e +a+A+ ++ +++++G++ l
    EFC39052.1 304 SMATLFEMLVKKQIDPYVSECYPIESVAKAMNDMLERKTVGRVLL 348
                   5****************************************9976 PP

>> ADH_N  Alcohol dehydrogenase GroES-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.1     6e-10   1.5e-06       2      61 ..      42     101 ..      41     107 .. 0.95
   2 ?    0.6   0.1       0.2   5.1e+02      59      76 ..     190     207 ..     172     222 .. 0.77

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 6e-10
                 TEEEEEEEEEEE-HHHHHHHTTSTTTTSSSSEE---EEEEEEEEESTT-CS--TT-EEEE CS
       ADH_N   2 gevlikvkaagiCgsDlhilkggkelevklplilGHEivGeveevgpevkklkvGdrVvv 61 
                 + v+ik+ + +++  D     g+ + ++++p+i+G E++G+v +v+ + +++kvGd V++
  EFC39052.1  42 NHVRIKILYGCLNYADALQCGGKYQEKMNAPFIPGKELAGIVCDVNGKGDRFKVGDCVIM 101
                 789******************************************************997 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.2
                 EEE-SEEE-SSSHHHHTT CS
       ADH_N  59 VvvepliscgeCaaCkeg 76 
                 +v+ + +s+++C+ C+e+
  EFC39052.1 190 IVIAACSSDEKCKICTEK 207
                 455577788999999874 PP

>> AlaDh_PNT_C  Alanine dehydrogenase/PNT, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.1   6.6e-08   0.00017      21      89 ..     160     227 ..     143     231 .. 0.76

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 6.6e-08
                  CEETCB---EEEEEST.SHHHHHHHHHHHHTT-EEEEEESSHHHHHHHHH.TTTCECEEHCHHHHHHHHHH CS
  AlaDh_PNT_C  21 GgvpgvepakvlviGg.GvaGlqAiatakglgakVtvlDvrparleqles.lgakfvevlksqeellaeav 89 
                  G+ +   +++vlv+G+ G +Gl+A+++ak+lga+V +   + ++ +   +  +a fv  ++s+++   ++v
   EFC39052.1 160 GKSK---RSTVLVLGAsGGVGLAAVQIAKSLGAIVIAACSSDEKCKICTEkGQADFVVNYSSNKKDWFKQV 227
                  4444...99******8799****************998777777776666477777777777776665555 PP

>> Eno-Rase_NADH_b  NAD(P)H binding domain of trans-2-enoyl-CoA reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.3   3.4e-06    0.0088      35      59 ..     159     184 ..     147     196 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 3.4e-06
                      ----.-SEEEEESTSSHHHHHH.HHH CS
  Eno-Rase_NADH_b  35 kiekgpkkvLviGaStGYGLAs.ria 59 
                      + +++  +vLv+GaS G GLA+ +ia
       EFC39052.1 159 DGKSKRSTVLVLGASGGVGLAAvQIA 184
                      33445789************972344 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1       2.1   5.3e+03     136     157 ..     127     148 ..     121     149 .. 0.74
   2 ?   14.6   0.1   6.5e-06     0.017       2      53 ..     166     213 ..     165     241 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.1
                 EGGGTSB-TTBHHHHHHHHHHH CS
   adh_short 136 SvagkvpvagvaaYsAsKaava 157
                 Sv  k++   ++aYs+s  a++
  EFC39052.1 127 SVDLKKAASLLVAYSTSHVALT 148
                 5555677778899999988876 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 6.5e-06
                 EEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHTTSEEEE CS
   adh_short   2 vvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkeegakala 53 
                 +vlv Gas+G+G+a ++   + Ga v+++ +s+ek++ + ++ ++     ++
  EFC39052.1 166 TVLVLGASGGVGLAAVQIAKSLGAIVIAACSSDEKCKICTEKGQA----DFV 213
                 79**************************88888998555444333....344 PP

>> ELFV_dehydrog  Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.1   9.5e-06     0.024      22      82 ..     155     216 ..     136     241 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 9.5e-06
                    HHHTTTS-STTEEEEEE--.SHHHHHHHHHHHHCT-EEEEE..EESSEEEEETTEE-HHHHHHH CS
  ELFV_dehydrog  22 lkklkldslegkrvaisGs.Gnvgsyaallltelgakvvav..sDssGviydpeGldieellel 82 
                    l + +++  + ++v + G  G vg +a++++++lga v+a   sD +  i+ ++G   + ++++
     EFC39052.1 155 LTQHDGK-SKRSTVLVLGAsGGVGLAAVQIAKSLGAIVIAAcsSDEKCKICTEKGQ-ADFVVNY 216
                    4554555.888899999999*******************9655899*******994.4444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (361 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       590  (0.0329076); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 2118.44
//
Query:       EFC39053.1  [L=523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.9e-15   55.6   0.5    1.1e-14   54.5   0.5    1.6  1  Pkinase      Protein kinase domain
    1.4e-07   31.1   0.1    2.4e-07   30.3   0.1    1.5  1  Pkinase_Tyr  Protein tyrosine kinase
     0.0087   15.9   0.0      0.025   14.4   0.0    1.8  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.5   0.5   1.8e-18   1.1e-14      96     231 ..     260     407 ..     247     454 .. 0.78

  Alignments for each domain:
  == domain 1  score: 54.5 bits;  conditional E-value: 1.8e-18
                 -HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS...........BCTTTSCGGGS-HHHH.TTSCB.SHHHHHH CS
     Pkinase  96 seeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...........ltsfvgtseYlAPEvl.keney.skkvDvW 181
                 + e+a k++ q+l  +  +H  + iH D+K +Ni i  ++  K++DF lak+++s  +           + s  gt++ ++PE   ++++y ++ +D++
  EFC39053.1 260 DFEKALKMIVQLLVEMGNVHMLQYIHNDVKRSNIVIY-NNFTKLIDFELAKNFDSYDRenqicelfgdkVYSKAGTPNMMPPEKEkTGSGYiTPMTDIY 357
                 556777899999999**********************.99*************99888899********9*************997567777******* PP

                 HHHHHHHHHHHSS-...STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHT CS
     Pkinase 182 slGvilyelltgkp...pfsgekgkekvekeldqlekilkilgetkeklpeas 231
                  lG+++ e+l ++    pfs  +++++v +++++ +++ +i ++ k+ +++++
  EFC39053.1 358 CLGIVISEILDRNLtvsPFS--ENQKRVITKIRE-MSTNMIHKDPKQRWDTDR 407
                 **********9886212555..444555666666.444444445455555444 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   0.1   3.9e-11   2.4e-07      98     222 ..     257     391 ..     127     411 .. 0.79

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 3.9e-11
                  TTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEET..TTSSEE......EETTSSTSGGGGS-HHHHHHSE..EEHH CS
  Pkinase_Tyr  98 ekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardi..ekddey......vkkeeaklpvkWmapEslkekk..ftsk 185
                   kl++++ l++++q+   m  ++  +++H d+   N+++  n++ k+ Df La++   ++++++       k  ++    + m+pE  k+++  +t  
   EFC39053.1 257 VKLDFEKALKMIVQLLVEMGNVHMLQYIHNDVKRSNIVIY-NNFTKLIDFELAKNFdsYDRENQicelfgDKVYSKAGTPNMMPPEKEKTGSgyITPM 353
                  578999*********************************9.899**********99433334435555543444556677899**999988787999* PP

                  HHHHHHHHHHHHHHTTSSGTTTTS.HHHHHHHHHHTTE CS
  Pkinase_Tyr 186 sDvWsfGvllwEiftlgespypgl.kneevleklkegk 222
                  +D+++ G+++ Ei+    +  p   ++++v++k++e  
   EFC39053.1 354 TDIYCLGIVISEILDRNLTVSPFSeNQKRVITKIREMS 391
                  *************9866544443424455666665544 PP

>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0   4.2e-06     0.025      72     116 ..     481     523 .]     479     523 .] 0.91

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 4.2e-06
                  EEE--TTS-HHHHHHHHHHHHHHHHHCTTSEEEEEE-CGGCCSHH CS
  Cofilin_ADF  72 IswvPdsapikqkmlyasskdalkkelkgisveieatdldeltee 116
                  ++w+P++  i  k  +a++ +a+k++l+g+s +i +++++e++e+
   EFC39053.1 481 LAWCPNE--INVKYQVATTVKAVKQKLHGLSATILCSTKSEVDEK 523
                  58*****..6677789**************************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       919  (0.0512577); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 3005.31
//
Query:       EFC39054.1  [L=119]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       396  (0.0220871); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.33s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 691.26
//
Query:       EFC39055.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.4e-55  182.1   2.7    1.8e-16   59.5   0.1    4.3  4  DUF4116       Domain of unknown function (DUF4116)
     0.0018   17.9   0.0        2.2    8.1   0.0    3.0  3  zf_C2H2_6     Zinc Finger domain
  ------ inclusion threshold ------
        0.1   12.5   0.0         10    6.1   0.1    2.4  2  GA-like       GA-like domain
       0.11   12.5   0.0       0.72    9.9   0.0    2.1  2  Hpr_kinase_N  HPr Serine kinase N terminus


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.1   0.0   1.4e-15   6.1e-12       6      44 ..       1      39 [.       1      41 [. 0.96
   2 !   45.0   0.1   1.4e-15   6.5e-12       1      44 [.      21      64 ..      21      68 .. 0.92
   3 !   48.7   0.0     1e-16   4.5e-13       1      38 [.      71     108 ..      71     108 .. 0.97
   4 !   59.5   0.1   4.1e-20   1.8e-16       2      49 .]      97     158 ..      97     158 .. 0.96

  Alignments for each domain:
  == domain 1  score: 45.1 bits;  conditional E-value: 1.4e-15
     DUF4116  6 leavkkngsalkylseeLknDkeivlkAvkqngtalsya 44
                + a+++ng+a++y+see++nD+eiv++ + + g+al+y+
  EFC39055.1  1 MAAIDQNGYAIQYASEEIRNDREIVKRSISRAGCALRYI 39
                689***********************************8 PP

  == domain 2  score: 45.0 bits;  conditional E-value: 1.4e-15
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44
                DrEiv+  +++ g+al+y+ eeLk+D+eiv++Av+ n  al  +
  EFC39055.1 21 DREIVKRSISRAGCALRYIAEELKQDREIVMEAVNENAMALADV 64
                9************************************9988655 PP

  == domain 3  score: 48.7 bits;  conditional E-value: 1e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 DrEiv  av ++g++++++s+eL+nDkei+++A+k+ g
  EFC39055.1  71 DREIVSLAVNTDGNIIRFASPELRNDKEIAMQALKKKG 108
                 9**********************************876 PP

  == domain 4  score: 59.5 bits;  conditional E-value: 4.1e-20
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngt..............alsyaseeLr 49 
                 +Ei+++a+kk g+++kylse+L+nDke++++A++++g+              +l+y+se+ r
  EFC39055.1  97 KEIAMQALKKKGMSIKYLSENLRNDKEVAMQALQSCGItgrsfglyihtkesPLDYLSESVR 158
                 7************************************88999******99999*****9876 PP

>> zf_C2H2_6  Zinc Finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.1   0.0   0.00049       2.2       8      23 ..      34      49 ..      33      52 .. 0.93
   2 ?   -1.8   0.1      0.58   2.6e+03       2       7 ..      62      67 ..      62      68 .. 0.77
   3 !    6.2   0.0    0.0019       8.5      10      23 ..      86      99 ..      85     100 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00049
   zf_C2H2_6  8 CsLRFsSpeLKkeHEa 23
                C LR+   eLK++ E+
  EFC39055.1 34 CALRYIAEELKQDREI 49
                *************885 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.58
   zf_C2H2_6  2 AtVCpY 7 
                A VC Y
  EFC39055.1 62 ADVCNY 67
                569998 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0019
   zf_C2H2_6 10 LRFsSpeLKkeHEa 23
                +RF SpeL  + E+
  EFC39055.1 86 IRFASPELRNDKEI 99
                59*******99886 PP

>> GA-like  GA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.1    0.0023        10       7      31 ..      92     115 ..      88     116 .. 0.88
   2 ?    4.5   0.0    0.0074        33       6      25 ..     116     135 ..     114     144 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0023
     GA-like   7 aLkeAKeaAkaeLkaaGitsdfyie 31 
                 +L   Ke A ++Lk+ G  s +y++
  EFC39055.1  92 ELRNDKEIAMQALKKKGM-SIKYLS 115
                 78888*************.999986 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0074
     GA-like   6 eaLkeAKeaAkaeLkaaGit 25 
                 e L   Ke A ++L++ Git
  EFC39055.1 116 ENLRNDKEVAMQALQSCGIT 135
                 778899*************8 PP

>> Hpr_kinase_N  HPr Serine kinase N terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.033   1.5e+02      10      38 ..       7      36 ..       3      44 .. 0.70
   2 ?    9.9   0.0   0.00016      0.72      12      49 ..      34      72 ..      25     128 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.033
                  TTEEEEE..GGTT-E...E-EECEEE-HHHH CS
  Hpr_kinase_N 10 lklelll..geegldrreitssdinrpgleL 38
                  ++  + +  +e  + +rei +++i+r g +L
    EFC39055.1  7 NGYAIQYasEEIRN-DREIVKRSISRAGCAL 36
                  55555554244444.455**********998 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00016
                  EEEEE.GGTT-E...E-EECEEE-HHHHTTS--S-.--E CS
  Hpr_kinase_N 12 lelll.geegldrreitssdinrpgleLaGffdyfdper 49
                    l++  ee  ++rei  +++n  +++La++ +yf ++r
    EFC39055.1 34 CALRYiAEELKQDREIVMEAVNENAMALADVCNYFGNDR 72
                  445554344444556********************9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       899  (0.0501422); expected 358.6 (0.02)
Passed bias filter:                      604  (0.0336884); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 945.96
//
Query:       EFC39056.1  [L=206]
Description: hypothetical protein NAEGRDRAFT_73058 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.3e-14   52.5   0.4      1e-13   51.3   0.1    1.6  2  CDKN3            Cyclin-dependent kinase inhibitor 3 (CDKN3)
    9.6e-07   28.7   0.1    2.2e-06   27.5   0.1    1.7  1  DSPc             Dual specificity phosphatase, catalytic doma
    7.9e-06   25.6   1.3    0.00011   21.8   0.3    2.1  2  Y_phosphatase    Protein-tyrosine phosphatase
    0.00025   21.1   0.0    0.00036   20.6   0.0    1.3  1  Y_phosphatase3   Tyrosine phosphatase family
     0.0003   20.9   0.0    0.00046   20.3   0.0    1.3  1  PTPlike_phytase  Inositol hexakisphosphate
     0.0023   18.4   0.0      0.059   13.9   0.0    2.2  2  Rhodanese        Rhodanese-like domain
  ------ inclusion threshold ------
      0.011   16.0   0.1       0.11   12.8   0.0    2.1  2  Init_tRNA_PT     Rit1 DUSP-like domain
      0.053   12.9   0.1        1.8    8.0   0.0    2.8  3  DUF1256          Protein of unknown function (DUF1256)
        0.1   11.8   0.0       0.13   11.4   0.0    1.1  1  GSP_synth        Glutathionylspermidine synthase preATP-grasp
       0.15   11.7   0.0        1.1    8.8   0.0    2.0  2  DAGK_cat         Diacylglycerol kinase catalytic domain


Domain annotation for each model (and alignments):
>> CDKN3  Cyclin-dependent kinase inhibitor 3 (CDKN3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.3   0.1   5.8e-17     1e-13      37     158 ..      27     151 ..       6     162 .. 0.84
   2 ?   -1.5   0.0      0.94   1.7e+03      24      33 ..     182     191 ..     178     199 .. 0.84

  Alignments for each domain:
  == domain 1  score: 51.3 bits;  conditional E-value: 5.8e-17
                 GT-SSEEEEES-TT-EETTEEB-HHHHHHHHHH.TT--EEEE-S-HHHHHHTT-TTHH.HHHHHTT-EEEE----TTS--.-HHHHHHHHHHHHHHHHT CS
       CDKN3  37 vncsqflglcalpgckfkdvrrnvqkdteelks.ygiqdvfvfctrgelskyrvpnll.dlyqqygivthhhpiadggtp.diascleimeelatclkn 132
                 +n + +lg+   pg + k  rrn+q+d e ++  +  q ++ ++   el +  + + l  + q++g+ + h pi d   p d    +++++e+   l n
  EFC39056.1  27 MNETCMLGMMMCPGRNKKIHRRNLQQDLERIRDkFDGQTIVTLVRNEELEEMNIVEYLpKIKQEFGMKSIHFPIRDKSLPnDKEEFCKLIDEIIQELIN 125
                 577789************************986267899999999999*999877665278999**************99567899************* PP

                 T--EEEE-SSSSSHHHHHHHHHHHHH CS
       CDKN3 133 yrktlihcygglgrsclvaaclllyl 158
                  r+ ++hc gg gr++ v++++l  l
  EFC39056.1 126 GRRVIVHCNGGKGRAATVCTAVLQVL 151
                 ***************99887777555 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.94
                 TS----EEEE CS
       CDKN3  24 qtpiqiswls 33 
                 q piqi wl 
  EFC39056.1 182 QNPIQIIWLK 191
                 89******97 PP

>> DSPc  Dual specificity phosphatase, catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.5   0.1   1.2e-09   2.2e-06      34     106 ..      87     161 ..      65     193 .. 0.76

  Alignments for each domain:
  == domain 1  score: 27.5 bits;  conditional E-value: 1.2e-09
                 CCTTTTSEEEEECCESSTTSCCGGGHHHHHHHHHHHHHTT-EEEEEESSSSSHHHHHHHHHH..HHHHTSCHHHH CS
        DSPc  34 alkkseieklripvedehetkiskyleeavefidkakqkgkkvlVHCqaGisRSatliiaYl..mktknlslnea 106
                 ++++ + + ++ p++d++  +  +++ ++++ i +   +g++v+VHC+ G  R at+++a l  +k ++++ +e 
  EFC39056.1  87 IKQEFGMKSIHFPIRDKSLPNDKEEFCKLIDEIIQELINGRRVIVHCNGGKGRAATVCTAVLqvLKVRKVKCQEY 161
                 3455577889999***9999999999999999999999*********************9764455555554443 PP

>> Y_phosphatase  Protein-tyrosine phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.041        74      68     100 ..      64      93 ..      58     102 .. 0.79
   2 !   21.8   0.3   6.2e-08   0.00011     145     217 ..     102     177 ..      96     195 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.041
                    -EEEEESBSEETTEESS---S-SSTSSEEEETT CS
  Y_phosphatase  68 kvivmLtsleekgrekcaqYwpeeeeesleygk 100
                    ++iv L++ ee+++ ++ +Y p   + ++e+g 
     EFC39056.1  64 QTIVTLVRNEELEEMNIVEYLP---KIKQEFGM 93 
                    79********************...44444444 PP

  == domain 2  score: 21.8 bits;  conditional E-value: 6.2e-08
                    SSSSGSCCHHHHHHHHHHHHHHSTTSS-EEEECSSSSHHHHHHHHHHHHHHHHHHHSE....EEHHHHHHHHHTTST CS
  Y_phosphatase 145 dhgvpesaksllklirkvekskeaksgpvvVhCsaGvgRtgtfvaldillqqleaeee....vdvlqivkelrkqRp 217
                    d++ p++++++ kli+++ ++   +   v+VhC  G gR++t++++ + + ++++ ++     +  +++  +r+ R 
     EFC39056.1 102 DKSLPNDKEEFCKLIDEIIQEL-INGRRVIVHCNGGKGRAATVCTAVLQVLKVRKVKCqeyiSSSSNAMTIVRTTRG 177
                    7889**************9999.7899*******************9999999996665566555556666666664 PP

>> Y_phosphatase3  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0     2e-07   0.00036     105     162 ..     107     167 ..      41     187 .. 0.71

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 2e-07
  Y_phosphatase3 105 sakkayrkvfealadee.....pvlfHCtaGKDRTGvlaalllsllGvdeedivaDYlltney 162
                     + k+++ k+++++++ e      v++HC  GK R   ++  +l++l v + +  ++Y  +  +
      EFC39056.1 107 NDKEEFCKLIDEIIQ-ElingrRVIVHCNGGKGRAATVCTAVLQVLKVRKVK-CQEYISSSSN 167
                     556666666666666.223458**************************8765.6778777666 PP

>> PTPlike_phytase  Inositol hexakisphosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.0   2.6e-07   0.00046      55     151 ..      59     146 ..      41     151 .. 0.70

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 2.6e-07
                      EEEHHHHHTT-CCG-EEE-S-............EE-HHHHHHHTT-EEEEEEE-TTS---H.HHHHHHHH.HHHTS-TT-EEEEE-SSSSHHHH CS
  PTPlike_phytase  55 kksegrvlvhdeteegkdvktlqevweevetpeevyerelaeelslrYaRipitdekapee.edfdalvs.ilkeapektalvfnCqmGrgRTT 146
                       k++g+ +v+   +e+  +++          + ++y  ++++e++++   +pi d+  p++ e+f +l++ i++e+ +   ++++C  G+gR  
       EFC39056.1  59 DKFDGQTIVTLVRNEE--LEE---------MNIVEYLPKIKQEFGMKSIHFPIRDKSLPNDkEEFCKLIDeIIQELINGRRVIVHCNGGKGRAA 141
                      4444444442222222..222.........3335688999*******************8625799999625555599**************98 PP

                      HHHHH CS
  PTPlike_phytase 147 tamvi 151
                      t+ ++
       EFC39056.1 142 TVCTA 146
                      87654 PP

>> Rhodanese  Rhodanese-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.14   2.4e+02      44      74 ..      43      71 ..      39      94 .. 0.83
   2 !   13.9   0.0   3.3e-05     0.059      34      87 ..      96     149 ..      92     162 .. 0.63

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.14
   Rhodanese 44 akkseapllelpeellelgidnkktvvvycd 74
                 k + ++l++++e+++++  ++++t+v++ +
  EFC39056.1 43 KKIHRRNLQQDLERIRDK--FDGQTIVTLVR 71
                56788999**********..99999998765 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 3.3e-05
   Rhodanese  34 vnvskdtlsrakkseapllelpeellelgidnkktvvvycdgggraaaa..aallk 87 
                 +++   + +    +++++ +l++e++++ + n+++v+v+c+gg++ aa+  +a l+
  EFC39056.1  96 IHF-PIRDKSLPNDKEEFCKLIDEIIQE-LINGRRVIVHCNGGKGRAATvcTAVLQ 149
                 555.334444445555566666666665.999*************55553433443 PP

>> Init_tRNA_PT  Rit1 DUSP-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.28   5.1e+02       8      28 ..      41      61 ..      35      72 .. 0.81
   2 ?   12.8   0.0     6e-05      0.11      21      63 ..     112     152 ..      85     174 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.28
  Init_tRNA_PT  8 gsgKkgsknLrtalpkivdfv 28
                  +++K +++nL++ l++i d +
    EFC39056.1 41 RNKKIHRRNLQQDLERIRDKF 61
                  567999********9998765 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 6e-05
  Init_tRNA_PT  21 lpkivdfvrkrlsedkkkkilvacetGkdlsvgvaLailcklf 63 
                   + k++d + + l++++  +++v+c+ Gk  ++ v+ a+l+ l 
    EFC39056.1 112 FCKLIDEIIQELINGR--RVIVHCNGGKGRAATVCTAVLQVLK 152
                   4455666666666666..9*****************9998765 PP

>> DUF1256  Protein of unknown function (DUF1256)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.0     0.001       1.8      67      92 ..      43      68 ..      40      71 .. 0.91
   2 ?    1.2   0.0      0.12   2.2e+02      68      90 ..      74      96 ..      68     111 .. 0.83
   3 ?   -1.2   0.0      0.66   1.2e+03      63      77 ..     179     193 ..     171     203 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.001
     DUF1256 67 epvhalNlkeklkeIkkkyknpfiia 92
                + +h  Nl++ l++I++k++ ++i++
  EFC39056.1 43 KKIHRRNLQQDLERIRDKFDGQTIVT 68
                579*******************9986 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.12
     DUF1256 68 pvhalNlkeklkeIkkkyknpfi 90
                 + ++N+ e l +Ik+++ ++ i
  EFC39056.1 74 ELEEMNIVEYLPKIKQEFGMKSI 96
                57899************988776 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.66
     DUF1256  63 GtleepvhalNlkek 77 
                 Gtl++p++ + lk k
  EFC39056.1 179 GTLQNPIQIIWLKTK 193
                 9******99988876 PP

>> GSP_synth  Glutathionylspermidine synthase preATP-grasp
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   7.3e-05      0.13     149     219 ..      52     122 ..      38     125 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 7.3e-05
   GSP_synth 149 erfkeltleeekeklhfsavedseEDratvayLqdtakeagleteflpiedigldeeegrfvdadgrkiel 219
                 + +++ + + ++++++    +++ E+ + v+yL ++ +e g++  ++pi+d  l +++++f+++ ++ i+ 
  EFC39056.1  52 QDLERIRDKFDGQTIVTLVRNEELEEMNIVEYLPKIKQEFGMKSIHFPIRDKSLPNDKEEFCKLIDEIIQE 122
                 444442233456777777777788*******************************99****9998887765 PP

>> DAGK_cat  Diacylglycerol kinase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.0   0.00064       1.1      14      77 ..      79     149 ..      66     159 .. 0.74
   2 ?    7.1   0.0    0.0022       3.9       4      48 ..     129     172 ..     126     182 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00064
                 THHHHHHHCHHHHHHCTCEEEEEE--STTHHHHHHHHHHH.......CC-SEEEEEESHHHHHHHHHHHCT CS
    DAGK_cat  14 kgekllrkvrelleeagvelelieteepgdakelakeake.......egvdlivvaGGDGtvsevlnglle 77 
                 ++ ++l k+++ +  + +++ +++ + p+d +e++k ++e        +  ++ + GG G +  v+ ++l+
  EFC39056.1  79 NIVEYLPKIKQEFGMKSIHFPIRDKSLPNDKEEFCKLIDEiiqelinGRRVIVHCNGGKGRAATVCTAVLQ 149
                 56678889999999999999999999999999998888884444432244555577999999999999987 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0022
                 EEE-TTCTTTTHHHHHHHCHHHHHHCTCEEEEEE--STTHHHHHH CS
    DAGK_cat   4 vivNpksGkgkgekllrkvrelleeagvelelieteepgdakela 48 
                 viv+ ++Gkg++++++  v ++l+ ++v+++ +  + +  a +++
  EFC39056.1 129 VIVHCNGGKGRAATVCTAVLQVLKVRKVKCQEYISS-SSNAMTIV 172
                 99**************************98877765.44455555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (206 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       889  (0.0495845); expected 358.6 (0.02)
Passed bias filter:                      673  (0.037537); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.64u 0.34s 00:00:00.98 Elapsed: 00:00:00.55
# Mc/sec: 1124.71
//
Query:       EFC39057.1  [L=227]
Description: vesicle transport v-snare protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.8e-16   59.2   3.5    3.8e-16   59.2   3.5    2.4  2  V-SNARE         Vesicle transport v-SNARE protein N-terminus
    8.9e-13   48.3   5.2    2.5e-12   46.9   2.4    2.3  2  V-SNARE_C       Snare region anchored in the vesicle membrane
    5.1e-07   29.5   6.4    1.4e-06   28.1   0.2    3.6  5  Sec20           Sec20
    0.00034   20.1   0.7    0.00048   19.6   0.7    1.4  1  DUF4407         Domain of unknown function (DUF4407)
    0.00063   19.7   0.4    0.00063   19.7   0.4    2.2  2  DUF5089         Domain of unknown function (DUF5089)
  ------ inclusion threshold ------
      0.016   15.5   1.1      0.025   14.9   0.0    1.9  2  DUF5534         Family of unknown function (DUF5534)
      0.025   13.7  10.0      0.043   12.9  10.0    1.3  1  Atg14           Vacuolar sorting 38 and autophagy-related sub
      0.029   14.7   1.7      0.029   14.7   1.7    3.2  2  CCDC-167        Coiled-coil domain-containing protein 167
      0.032   13.5   0.1      0.064   12.5   0.0    1.4  2  COOH-NH2_lig    Phage phiEco32-like COOH.NH2 ligase-type 2
      0.058   11.6   3.9        1.8    6.7   0.0    2.7  3  Fusion_gly      Fusion glycoprotein F0
      0.081   13.0   5.0          5    7.3   0.1    2.9  3  MetOD2          Metanogen output domain 2
       0.17   12.5   7.8       0.17   12.5   0.7    2.7  3  DUF883          Bacterial protein of unknown function (DUF883
        0.2   11.6   2.1       0.27   11.1   0.2    2.1  2  DUF2721         Protein of unknown function (DUF2721)
       0.32   11.3   9.1       0.34   11.2   3.2    2.1  2  THOC7           Tho complex subunit 7
        0.6   10.1   5.6        1.2    9.2   0.2    3.2  4  DUF2205         Short coiled-coil protein
       0.65   10.5  10.8      0.038   14.4   4.1    2.1  2  Enkurin         Calmodulin-binding
          1   10.3  14.2       0.52   11.2   7.4    2.8  2  PRKG1_interact  cGMP-dependent protein kinase interacting dom
        1.8    8.9  11.1       0.22   11.9   3.1    2.3  2  YlqD            YlqD protein
        2.5    8.4  10.8       0.47   10.8   1.0    3.3  3  KxDL            Uncharacterized conserved protein
        2.6    8.4   6.5        5.2    7.4   6.5    1.5  1  Sigma_reg_N     Sigma factor regulator N-terminal
        4.8    7.2  15.2       0.37   10.8   6.6    2.9  3  TMF_DNA_bd      TATA element modulatory factor 1 DNA binding
        6.8    6.7   6.1         18    5.3   6.1    1.7  1  Syndecan        Syndecan domain
          8    5.1  10.8         53    2.4  10.8    1.9  1  DUF2207         Predicted membrane protein (DUF2207)
        8.6    6.7  12.6        5.2    7.4   6.9    2.4  2  OmpH            Outer membrane protein (OmpH-like)


Domain annotation for each model (and alignments):
>> V-SNARE  Vesicle transport v-SNARE protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.2   3.5   5.1e-19   3.8e-16       4      78 ..      15      90 ..      12      91 .. 0.95
   2 ?    0.4   0.7       1.2     9e+02      21      36 ..     131     146 ..     110     182 .. 0.59

  Alignments for each domain:
  == domain 1  score: 59.2 bits;  conditional E-value: 5.1e-19
     V-SNARE  4 llaeiksklarlsslageerkaalreiekkldeaeelldqMelEvrnl.psserasykaklreykselkklkkelk 78
                 ++ ik+ la l+s +g+ +k+ +r+iek+ld a++ ++qM+lE  ++  ++e+ ++k+kl+ y ++l +lkke++
  EFC39057.1 15 ASNGIKRSLAELKSVSGDAKKRVVRKIEKDLDTANKQIKQMNLEMTSTaNPQEKENLKKKLKTYGQDLTNLKKEFE 90
                6788******************************************99866***********************96 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 1.2
     V-SNARE  21 eerkaalreiekklde 36 
                 e  +++l ++ k lde
  EFC39057.1 131 ERSNETLDRASKILDE 146
                 3333333333333333 PP

>> V-SNARE_C  Snare region anchored in the vesicle membrane C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.38   2.8e+02      39      63 ..      31      56 ..      10      59 .. 0.75
   2 !   46.9   2.4   3.4e-15   2.5e-12       3      65 ..     130     192 ..     128     193 .. 0.98

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.38
   V-SNARE_C 39 krarsk.lhnvanrlgksnsiLrsik 63
                ++a+++ ++ + ++l+++n+ ++ ++
  EFC39057.1 31 GDAKKRvVRKIEKDLDTANKQIKQMN 56
                566666257899**********9998 PP

  == domain 2  score: 46.9 bits;  conditional E-value: 3.4e-15
   V-SNARE_C   3 llresdrlknShrivdetisiGaailedLhsQretLkrarsklhnvanrlgksnsiLrsikrR 65 
                 l+r+++ l++++ i+det++ G+++ ++L++Q e++k +r+kl +v+++++   +iL +++rR
  EFC39057.1 130 LERSNETLDRASKILDETEQMGVETAGTLREQGERMKKTRDKLYDVDSQIKQGGRILGRMSRR 192
                 89************************************************************9 PP

>> Sec20  Sec20
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0       1.5   1.1e+03      40      61 ..       7      28 ..       2      52 .. 0.72
   2 ?   -0.6   0.2       1.7   1.3e+03      39      53 ..      39      53 ..      14      70 .. 0.53
   3 ?    0.9   0.4      0.57   4.3e+02      23      51 ..      66      95 ..      46     105 .. 0.71
   4 ?    5.8   0.1     0.017        13      26      57 ..     118     149 ..     114     150 .. 0.85
   5 !   28.1   0.2   1.9e-09   1.4e-06       8      85 ..     135     212 ..     133     219 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 1.5
       Sec20 40 kleeeykqvedvlsrskklvkk 61
                + e+ey++ ++ ++rs   +k+
  EFC39057.1  7 SYEDEYFEASNGIKRSLAELKS 28
                5678888888888777554444 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.7
       Sec20 39 ekleeeykqvedvls 53
                 k+e ++   ++ ++
  EFC39057.1 39 RKIEKDLDTANKQIK 53
                333333333333332 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.57
       Sec20 23 qSeenl.eeldastkslekleeeykqvedv 51
                q +enl ++l++  ++l++l+ e+ + ++ 
  EFC39057.1 66 QEKENLkKKLKTYGQDLTNLKKEFEGAKSD 95
                455666247999999999999999988765 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.017
       Sec20  26 enleeldastkslekleeeykqvedvlsrskk 57 
                    + l++st++le+ +e +   +++l  +++
  EFC39057.1 118 DYRNRLVQSTQVLERSNETLDRASKILDETEQ 149
                 556789****************9999998876 PP

  == domain 5  score: 28.1 bits;  conditional E-value: 1.9e-09
       Sec20   8 eslraisqllsqevqqSeenleeldastkslekleeeykqvedvlsrskklvkklerrdktdkllvflalglflacvv 85 
                 e l + s++l ++ q+  e++ +l+++ + ++k+ +++ +v++ ++++ +++  + rr++  k++++  + ++l+++ 
  EFC39057.1 135 ETLDRASKILDETEQMGVETAGTLREQGERMKKTRDKLYDVDSQIKQGGRILGRMSRREVLIKVIIIAVILFLLLIIG 212
                 678999*********************************************************999888777777654 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.7   6.4e-07   0.00048     109     274 ..      49     210 ..       9     225 .. 0.55

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 6.4e-07
     DUF4407 109 daelaeeqqeeakelkeqlaaaltaelaeleaqiaalqaeidaaearldalraeaqkeldgtk.....gtgttgvaGkgpaakekkaqldaaqaelael 202
                 ++++++++ e++++++ q +++l+++l++  +++++l++e++ a+++ +++r+++ +    +       +  ++     ++ ++ ++ ld+a++ l+e 
  EFC39057.1  49 NKQIKQMNLEMTSTANPQEKENLKKKLKTYGQDLTNLKKEFEGAKSDNNRNRDALFSGGYDDDlpsasDDYRNRLVQSTQVLERSNETLDRASKILDET 147
                 466777777777777777777777777777777777777777777777777777664433322333221122222223333333444444444444443 PP

     DUF4407 203 kakldatarlaalraelaeleaerakeraasqaaaaaddGllarlealdrltkedatallarlllfllflai 274
                 ++     ++  +lr++ ++        +++ ++  + d+ + +  ++l+r+++++  + ++ ++++l++l+i
  EFC39057.1 148 EQM--GVETAGTLREQGER-------MKKTRDKLYDVDSQIKQGGRILGRMSRREVLIKVIIIAVILFLLLI 210
                 333..33333333333333.......3333333333344444445566666666665555555555555544 PP

>> DUF5089  Domain of unknown function (DUF5089)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   2.3      0.73   5.4e+02     151     171 ..      40      60 ..       9     100 .. 0.55
   2 !   19.7   0.4   8.4e-07   0.00063       9      73 ..     128     192 ..     121     203 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.73
     DUF5089 151 slkkeaevQnkeikkqkskik 171
                 +++k++++ nk+ik+ + ++ 
  EFC39057.1  40 KIEKDLDTANKQIKQMNLEMT 60 
                 333333333333332222222 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 8.4e-07
     DUF5089   9 kiEeqnyetakkarkkLesaartqkkTtkelrkQgekLekakqsaikvhknaekgeelakkikre 73 
                 ++ e + et   a k L+++ +   +T  +lr+Qge ++k +++ ++v  ++++g  +  ++ r 
  EFC39057.1 128 QVLERSNETLDRASKILDETEQMGVETAGTLREQGERMKKTRDKLYDVDSQIKQGGRILGRMSRR 192
                 44444458888999****************************************98887777765 PP

>> DUF5534  Family of unknown function (DUF5534)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.3       2.9   2.2e+03      47      52 ..      60      65 ..      19      95 .. 0.58
   2 ?   14.9   0.0   3.3e-05     0.025      65     103 ..     185     222 ..     123     226 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 2.9
     DUF5534 47 aasrst 52
                +++ + 
  EFC39057.1 60 TSTANP 65
                332222 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 3.3e-05
     DUF5534  65 klaliphrPaLvkviliacvalsialicGiaisyviYrL 103
                  l  + +r  L+kvi+ia + + + li+Gi ++++ Y +
  EFC39057.1 185 ILGRMSRREVLIKVIIIAVILF-LLLIIGIILFFIFYGI 222
                 5556789**********98876.67999*******9965 PP

>> Atg14  Vacuolar sorting 38 and autophagy-related subunit 14
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9  10.0   5.7e-05     0.043      30     173 ..      22     177 ..      18     205 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 5.7e-05
       Atg14  30 rlaklksekeslkkkiekalegkeeaeqledkiknkkakleelksliadlrerlqelkdklsqlkkeieekkkklaklsdklk..............kR 114
                  la lks +   kk++ +++e+  ++ +++ k +n+ +      ++++ l+++l++  ++l++lkke e +k    +++d+l               +R
  EFC39057.1  22 SLAELKSVSGDAKKRVVRKIEKDLDTANKQIKQMNLEMTSTANPQEKENLKKKLKTYGQDLTNLKKEFEGAKSDNNRNRDALFsggydddlpsasddYR 120
                 799*********************66666666666666667777889999999999******************99999999999*********99888 PP

       Atg14 115 rsdleslqneleerrkkqiaklqdaikrieqklsslssktles..rsslcselaklyglrr 173
                 ++     ++++ er ++ +++ ++ + ++eq++ +   ++ e+  r+   ++  kly++  
  EFC39057.1 121 NRL--VQSTQVLERSNETLDRASKILDETEQMGVETAGTLREQgeRM--KKTRDKLYDVDS 177
                 888..667889999999999999999999999888887777763333..334446666655 PP

>> CCDC-167  Coiled-coil domain-containing protein 167
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   1.7   3.9e-05     0.029      14      64 ..      39      88 ..      21      92 .. 0.88
   2 ?   -2.2   5.3       7.3   5.5e+03      48      78 ..     169     203 ..     117     221 .. 0.59

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 3.9e-05
    CCDC-167 14 ascrerLeaverrlrkeelseeeResleeEeaslkeqleenekeLksLrke 64
                 +++++L++ ++++++ +l+        +E+++lk++l+++ + L++L+ke
  EFC39057.1 39 RKIEKDLDTANKQIKQMNLEMTSTA-NPQEKENLKKKLKTYGQDLTNLKKE 88
                5689999999*99999999988544.457********************99 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 7.3
    CCDC-167  48 keqleenekeLk....sLrkeNrksmllsvalllv 78 
                 + +l + +++ k     L +  r+++l+ v++++v
  EFC39057.1 169 RDKLYDVDSQIKqggrILGRMSRREVLIKVIIIAV 203
                 33333333444333333444455555555555544 PP

>> COOH-NH2_lig  Phage phiEco32-like COOH.NH2 ligase-type 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   8.5e-05     0.064      37      89 ..      15      67 ..       9      72 .. 0.88
   2 ?   -3.7   0.0       7.4   5.6e+03       9      34 ..     130     155 ..     127     163 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8.5e-05
  COOH-NH2_lig 37 ereekelplaElRPapaedpaelleelrkllqeaaeliedknvewlaGsmpvk 89
                   ++  + +laEl+     + ++++++++k l +a+++i++ n+e+++ + p +
    EFC39057.1 15 ASNGIKRSLAELKSVSGDAKKRVVRKIEKDLDTANKQIKQMNLEMTSTANPQE 67
                  55566789**************************************9999976 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 7.4
  COOH-NH2_lig   9 lrkktgklvpasrflerdGavGcDar 34 
                   l ++++ l  as+ l+++ ++G+++ 
    EFC39057.1 130 LERSNETLDRASKILDETEQMGVETA 155
                   66677777778888887777777665 PP

>> Fusion_gly  Fusion glycoprotein F0
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.1      0.37   2.8e+02      23      58 ..      49      85 ..      19     104 .. 0.58
   2 ?    6.7   0.0    0.0024       1.8     431     467 ..     116     152 ..     107     158 .. 0.85
   3 ?    5.0   0.2    0.0079       5.9     438     484 ..     165     211 ..     160     215 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.37
                EEEEEEEEEE-S--GGGCCTTT.CCHHHHHHHHHHHH CS
  Fusion_gly 23 ssstsvivikllpnikelnkCt.kkeleeykkaltel 58
                +++ +++ +++ ++ ++++k + kk+l+ y + lt+l
  EFC39057.1 49 NKQIKQMNLEMTSTANPQEKENlKKKLKTYGQDLTNL 85
                2333444444444444443333355555555555555 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0024
                 HHHHHHHHHHHHHHHHHHHHHHHHHCCCCTCCCHHHH CS
  Fusion_gly 431 evdisaelskvnesleqskdlleesnkiLdsvnkkll 467
                 ++d    l + ++ le s + l+++ kiLd++++   
  EFC39057.1 116 SDDYRNRLVQSTQVLERSNETLDRASKILDETEQMGV 152
                 678888999999******************9988665 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0079
                 HHHHHHHHHHHHHHHHHHCCCCTCCCHHHHHTTXXXXXXXXXXXXXX CS
  Fusion_gly 438 lskvnesleqskdlleesnkiLdsvnkkllstaivivlivlvivvll 484
                 ++k  ++l +   ++++  +iL  + +     +++i++++l ++ ++
  EFC39057.1 165 MKKTRDKLYDVDSQIKQGGRILGRMSRREVLIKVIIIAVILFLLLII 211
                 677889999999*************9999999999999998877654 PP

>> MetOD2  Metanogen output domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.1      0.69   5.1e+02      57      87 ..      32      62 ..      17      63 .. 0.72
   2 ?    5.6   1.6     0.022        17      55      86 ..      60      91 ..      33      93 .. 0.75
   3 ?    7.3   0.1    0.0067         5      26      86 ..     121     181 ..      98     183 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.69
      MetOD2 57 eeieaalknlekkleaqeerlkqikkelest 87
                ++ ++ ++ +ek l + ++++kq++ e++st
  EFC39057.1 32 DAKKRVVRKIEKDLDTANKQIKQMNLEMTST 62
                4555777788888888888888877777766 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.022
      MetOD2 55 vseeieaalknlekkleaqeerlkqikkeles 86
                 s++  ++ +nl+kkl++  ++l ++kke+e 
  EFC39057.1 60 TSTANPQEKENLKKKLKTYGQDLTNLKKEFEG 91
                4555557778******************9986 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0067
      MetOD2  26 arLaksvevnkrllslLsqtydidddkaevseeieaalknlekkleaqeerlkqikkeles 86 
                  rL++s++v  r  + L ++++i d++ +++ e    l++  +++++   +l  +  ++++
  EFC39057.1 121 NRLVQSTQVLERSNETLDRASKILDETEQMGVETAGTLREQGERMKKTRDKLYDVDSQIKQ 181
                 599***********************************99999999999988887777765 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.4      0.19   1.4e+02      18      50 ..      23      55 ..       6      70 .. 0.53
   2 ?    1.8   0.4       0.5   3.8e+02       2      48 ..      40      90 ..      39     103 .. 0.57
   3 ?   12.5   0.7   0.00023      0.17       8      59 ..     134     184 ..     127     194 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.19
      DUF883 18 lkeaadeageeaeelRerleerlerarerlrda 50
                l e ++ +g+  +++ +++e+ l++a ++++++
  EFC39057.1 23 LAELKSVSGDAKKRVVRKIEKDLDTANKQIKQM 55
                334444444444455555555555555554444 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.5
      DUF883  2 eleaeleslladleel.lkeaadeageeaeelRerleer...lerarerlr 48
                ++e++l+++ ++++++ l+ ++    +e e+l+++l+ +   l++++++++
  EFC39057.1 40 KIEKDLDTANKQIKQMnLEMTSTANPQEKENLKKKLKTYgqdLTNLKKEFE 90
                567777777777777734445555556666777776644111444444444 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 0.00023
      DUF883   8 eslladleellkeaadeageeaeelRerleerlerarerlrdaeeavaerak 59 
                 ++ l+ + ++l+e+++ + e+a +lRe+  er++++r++l d+  ++++  +
  EFC39057.1 134 NETLDRASKILDETEQMGVETAGTLREQG-ERMKKTRDKLYDVDSQIKQGGR 184
                 67788999*******************97.689**********999988665 PP

>> DUF2721  Protein of unknown function (DUF2721)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1       1.7   1.3e+03      28      54 ..      51      76 ..      38     100 .. 0.75
   2 ?   11.1   0.2   0.00036      0.27      32      87 ..     158     220 ..     119     226 .. 0.66

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.7
     DUF2721 28 rirqLedeleelaeeeeedeelakeik 54
                +i+q++ e+ ++a+++e+ e+l+k++k
  EFC39057.1 51 QIKQMNLEMTSTANPQEK-ENLKKKLK 76
                577777777766666555.77777765 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00036
     DUF2721  32 Ledeleelaeeeeedeelake.......iknlrrRarlirrailllvlsallvvlvvlllfls 87 
                 L+++ e+ ++++++  +++ +       + +++rR  li+  i++++l +ll++ ++l+ ++ 
  EFC39057.1 158 LREQGERMKKTRDKLYDVDSQikqggriLGRMSRREVLIKVIIIAVILFLLLIIGIILFFIFY 220
                 3333333333333344444445566666779****************9999999998877664 PP

>> THOC7  Tho complex subunit 7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   3.2   0.00046      0.34      27     102 ..      26     100 ..       9     103 .. 0.83
   2 ?    3.6   0.3       0.1        78      58     107 ..     122     171 ..     113     183 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00046
       THOC7  27 ltslaesteeeleqlkedllldfaafelsie..rlqllakanerereryeaekeeieseieavreeieelkaqLeear 102
                 l+s    + ++ ++   +++ d+ + + +i+   l++ ++an +e+e+++++ ++  + + ++++e e  k+++ + r
  EFC39057.1  26 LKS---VSGDAKKRVVRKIEKDLDTANKQIKqmNLEMTSTANPQEKENLKKKLKTYGQDLTNLKKEFEGAKSDNNRNR 100
                 333...34567888889999999999999997789999*****************************99999887765 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.1
       THOC7  58 rlqllakanerereryeaekeeieseieavreei.eelkaqLeearatran 107
                 rl  +++  er  e +++  ++i++e+e++  e+   l++q e+ ++tr+ 
  EFC39057.1 122 RLVQSTQVLERSNETLDRA-SKILDETEQMGVETaGTLREQGERMKKTRDK 171
                 5666667777777777754.6688888888887735799999999999976 PP

>> DUF2205  Short coiled-coil protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       3.4   2.6e+03       5      26 ..      21      42 ..      19      54 .. 0.69
   2 ?    9.2   0.2    0.0015       1.2       6      48 ..      56      98 ..      51     117 .. 0.85
   3 ?    0.9   0.1      0.62   4.6e+02       8      41 ..     110     142 ..     105     154 .. 0.72
   4 ?    1.5   0.1      0.41   3.1e+02       8      37 ..     145     174 ..     138     183 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 3.4
     DUF2205  5 rnsedveklerearerLqqqak 26
                r+ ++++ ++ +a++r+ ++++
  EFC39057.1 21 RSLAELKSVSGDAKKRVVRKIE 42
                5567777777888887766654 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0015
     DUF2205  6 nsedveklerearerLqqqakeLqssLqaLaervdeVkeehdK 48
                n e+ + ++ +++e+L+++ k+  + L +L +  +  k+++++
  EFC39057.1 56 NLEMTSTANPQEKENLKKKLKTYGQDLTNLKKEFEGAKSDNNR 98
                56777888899*****************************987 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.62
     DUF2205   8 edveklerearerLqqqakeLqssLqaLaervde 41 
                 +d+  ++ + r+rL q  + L +s + L +r  +
  EFC39057.1 110 DDLPSASDDYRNRLVQSTQVLERSNETL-DRASK 142
                 5777788899999999999998886554.44444 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.41
     DUF2205   8 edveklerearerLqqqakeLqssLqaLae 37 
                 ++ e+++ e+  +L++q + ++++ ++L +
  EFC39057.1 145 DETEQMGVETAGTLREQGERMKKTRDKLYD 174
                 6889999*********99999999888876 PP

>> Enkurin  Calmodulin-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   4.1   5.1e-05     0.038      30      96 ..      21      87 ..       3      88 .. 0.86
   2 ?   -0.2   0.5       1.9   1.4e+03      13      19 ..     161     167 ..     120     197 .. 0.53

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 5.1e-05
     Enkurin 30 eappgmrllseeerqellegLkkkweelnkeyqslpllidtlskrqrKeklEkeLkqlEkdikllek 96
                +  ++++ +s + +++++++ +k ++  nk+ +++ l + + +  q+Ke+l k+Lk   +d+  l+k
  EFC39057.1 21 RSLAELKSVSGDAKKRVVRKIEKDLDTANKQIKQMNLEMTSTANPQEKENLKKKLKTYGQDLTNLKK 87
                3457889999999********************************************9999988876 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.9
     Enkurin  13 eleeeee 19 
                 + e++++
  EFC39057.1 161 QGERMKK 167
                 2222222 PP

>> PRKG1_interact  cGMP-dependent protein kinase interacting domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.6      0.44   3.3e+02      14      31 ..      39      56 ..       6      64 .. 0.47
   2 ?   11.2   7.4    0.0007      0.52      10      89 ..      65     168 ..      61     190 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.44
  PRKG1_interact 14 erLkreLeelekelselk 31
                    +++ + L++++k++++++
      EFC39057.1 39 RKIEKDLDTANKQIKQMN 56
                    222233333333333333 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.0007
  PRKG1_interact  10 keenerLkreLeelekelselkseleklkqqrqe.......................svskrssllelekrerrslerkiseleeel..keleeL 79 
                      +e+e+Lk++L++  ++l++lk+e+e +k+ +++                       ++ +++++le +++      + + e+e+ +  ++   L
      EFC39057.1  65 PQEKENLKKKLKTYGQDLTNLKKEFEGAKSDNNRnrdalfsggydddlpsasddyrnRLVQSTQVLERSNETLDRASKILDETEQ-MgvETAGTL 158
                     589***********************998775446799**999999999986654444444444444333333333333334433.234888899 PP

  PRKG1_interact  80 raenqrLkdE 89 
                     r++ +r+k+ 
      EFC39057.1 159 REQGERMKKT 168
                     9999999975 PP

>> YlqD  YlqD protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   3.1   0.00029      0.22      14      74 ..      30      98 ..      19     105 .. 0.82
   2 ?    1.9   0.7      0.37   2.7e+02      25      84 ..     123     180 ..     113     188 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00029
        YlqD 14 TeklKeelqqqlqaqieqldkelqqLefqakrlikeikkqsaq........qieeiqeqvekekserle 74
                  + K+++ +++++++++++k+++q+++++  + + ++k++ +          +++++++e  ks+ + 
  EFC39057.1 30 SGDAKKRVVRKIEKDLDTANKQIKQMNLEMTSTANPQEKENLKkklktygqDLTNLKKEFEGAKSDNNR 98
                567899****************************99999998887777777777777777777766555 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.37
        YlqD  25 lqaqieqldkelqqLefqakrlikeikkqsaqqieeiqeqvekekserlekkkqllqqle 84 
                 l ++ + l++  + L+    ++++e+++  ++++ +++eq e+ k+  ++k  ++++q++
  EFC39057.1 123 LVQSTQVLERSNETLDRA-SKILDETEQMGVETAGTLREQGERMKKT-RDKLYDVDSQIK 180
                 555555566666666644.3444666666676777777765544433.344455555555 PP

>> KxDL  Uncharacterized conserved protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   1.0   0.00064      0.47      42      79 ..      22      60 ..       1      67 [. 0.74
   2 ?    0.5   0.1      0.97   7.3e+02      45      64 ..      70      89 ..      63      98 .. 0.51
   3 ?    2.1   0.4      0.32   2.4e+02      33      48 ..     131     146 ..     117     191 .. 0.50

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00064
        KxDL 42 rlaklrarfkqgt.kllkevkkdLesifkkirslkakla 79
                 la+l++   + + ++++++ kdL++ +k+i++++ +++
  EFC39057.1 22 SLAELKSVSGDAKkRVVRKIEKDLDTANKQIKQMNLEMT 60
                5555555544444399******************97665 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.97
        KxDL 45 klrarfkqgtkllkevkkdL 64
                +l++++k + ++l ++kk+ 
  EFC39057.1 70 NLKKKLKTYGQDLTNLKKEF 89
                33344444444444444333 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.32
        KxDL  33 lelnalsqerlaklra 48 
                 ++ n+ +++  + l +
  EFC39057.1 131 ERSNETLDRASKILDE 146
                 2222222222222222 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   6.5     0.007       5.2       7      37 ..     190     220 ..     185     227 .] 0.79

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.007
  Sigma_reg_N   7 akrksilrivlislivlllifvilvvtllyl 37 
                   +r  ++++++i++i++ll+++ +++ + ++
   EFC39057.1 190 SRREVLIKVIIIAVILFLLLIIGIILFFIFY 220
                  589999*********9999999886655554 PP

>> TMF_DNA_bd  TATA element modulatory factor 1 DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   6.6   0.00049      0.37      23      73 ..      40      92 ..      38      93 .. 0.90
   2 ?    0.0   0.1       1.1   8.5e+02      40      54 ..     128     142 ..     112     154 .. 0.52
   3 ?    0.0   0.1       1.2   8.7e+02      17      31 ..     158     172 ..     153     181 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00049
  TMF_DNA_bd 23 kLskkelklnntikkLrkknkele..keikelkkkleklekeleeleerlkea 73
                k +k  +  n++ik+++ ++  +   +e ++lkkkl+++ ++l++l++++++a
  EFC39057.1 40 KIEKDLDTANKQIKQMNLEMTSTAnpQEKENLKKKLKTYGQDLTNLKKEFEGA 92
                6788889999********9999997789999******************9987 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 1.1
  TMF_DNA_bd  40 kknkelekeikelkk 54 
                 + ++ +++++++ +k
  EFC39057.1 128 QVLERSNETLDRASK 142
                 333334444444444 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 1.2
  TMF_DNA_bd  17 LmeEGekLskkelkl 31 
                 L+e Ge+ +k+ +kl
  EFC39057.1 158 LREQGERMKKTRDKL 172
                 666666666666654 PP

>> Syndecan  Syndecan domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   6.1     0.024        18       4      32 ..     190     219 ..     188     224 .. 0.69

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.024
    Syndecan   4 erpevlaav.iggvvvgllfaillvlflvY 32 
                 +r evl  v i +v++ ll++i ++lf ++
  EFC39057.1 190 SRREVLIKViIIAVILFLLLIIGIILFFIF 219
                 567777765156777778888888888775 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4  10.8     0.071        53     348     431 ..     149     220 ..      17     225 .. 0.46

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.071
     DUF2207 348 k..............kakkfkkalkkwksavkk..kergyfdkkgkkklkklsalglgliilglilillallllvlllvfllilllillliaiivlllf 430
                 +              + kk +++l ++ s++k+  +  g ++++  + l k+++++++l++l++i+i+l+++                          f
  EFC39057.1 149 QmgvetagtlreqgeRMKKTRDKLYDVDSQIKQggRILGRMSRR--EVLIKVIIIAVILFLLLIIGIILFFI--------------------------F 219
                 12222222222222233333333333333333344333333333..33334444444444444444433332..........................2 PP

     DUF2207 431 s 431
                 +
  EFC39057.1 220 Y 220
                 2 PP

>> OmpH  Outer membrane protein (OmpH-like)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   6.9     0.007       5.2      11      84 ..      13      90 ..       8     105 .. 0.55
   2 ?    3.8   6.3     0.091        68      27      91 ..      67     138 ..      66     186 .. 0.59

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.007
                HHHSHHHHHHHHHHHHHH........HHHHHHHHHHHHHHHHHHHHHHHHTTTS...-HHHHHHHHHHHHHHHHHHHHHHHHHH CS
        OmpH 11 leespegkaaqeqlekkf........kklqaeleakekelqklqeelqkkakkle..keekeqelqkkeqelqqkqqqkaqelq 84
                +e+s+  k+  ++l++ +        +k++++l++ +k+++++  e+       +  ++++++ l+kk + + q++ + ++e++
  EFC39057.1 13 FEASNGIKRSLAELKSVSgdakkrvvRKIEKDLDTANKQIKQMNLEMT------StaNPQEKENLKKKLKTYGQDLTNLKKEFE 90
                566777777777777776544444455666666666666666655554......232333333355555555555555555544 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.091
                 HHHHHHHHHHHHHHHHHHHHHHHHHHTTTS...-HHHHHH..........HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        OmpH  27 kfkklqaeleakekelqklqeelqkkakkl.e.keekeqe..........lqkkeqelqqkqqqkaqelqkkqqell 91 
                 ++++l+++l++ +++l++l++e++ +++++   +     +          l    +++++++ q  q l++ ++ l 
  EFC39057.1  67 EKENLKKKLKTYGQDLTNLKKEFEGAKSDNnRnR-----DalfsggydddLPSASDDYRNRLVQSTQVLERSNETLD 138
                 4556666666677777777777764443321121.....12333444445666666666655555444444443333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2649  (0.147749); expected 358.6 (0.02)
Passed bias filter:                     1141  (0.0636399); expected 358.6 (0.02)
Passed Vit filter:                       170  (0.00948185); expected 17.9 (0.001)
Passed Fwd filter:                        39  (0.00217525); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              24  [number of targets reported over threshold]
# CPU time: 0.83u 0.37s 00:00:01.20 Elapsed: 00:00:00.56
# Mc/sec: 1217.11
//
Query:       EFC39058.1  [L=339]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (339 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1582  (0.0882369); expected 358.6 (0.02)
Passed bias filter:                      609  (0.0339673); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2064.43
//
Query:       EFC39059.1  [L=1025]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-06   28.4  16.6      1e-06   28.4  16.6    3.4  3  Collagen  Collagen triple helix repeat (20 copies)


Domain annotation for each model (and alignments):
>> Collagen  Collagen triple helix repeat (20 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4  16.6   5.7e-11     1e-06       1      56 [.      82     137 ..      82     139 .. 0.90
   2 ?  -20.2  46.5         1   1.8e+04       4      52 ..     204     250 ..     202     258 .. 0.28
   3 ?   -1.3  15.3       0.1   1.8e+03       8      46 ..     280     316 ..     275     333 .. 0.39

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 5.7e-11
                 XXXXXXXXXXXXXXXXXX-----XXXXEEEE-TTSS-----------------BB- CS
    Collagen   1 GppGepGepGppGppGkrGepGeaGekGekGpaGekGppGaaGkpGapGekGeaGa 56 
                 G++G++G++G pG++G++G++G++ ++ + G++Ge+G++G +G++G + e+G++G+
  EFC39059.1  82 GAKGNNGQNGRPGKNGRPGRAGTTRSESKIGDRGENGEHGTNGEDGYHAENGRDGD 137
                 88999999999999999999999999999999999999999999999999999985 PP

  == domain 2  score: -20.2 bits;  conditional E-value: 1
                 XXXXXXXXXXXXXXX-----XXXXEEEE-TTSS---------------- CS
    Collagen   4 GepGepGppGppGkrGepGeaGekGekGpaGekGppGaaGkpGapGekG 52 
                 G +G +G +G +G +G +G +G++G   ++G +G +G +G +G + + G
  EFC39059.1 204 GGDGGDGGNGGHGGNGGSGGNGSNGT--EQGGDGGDGGNGGDGGRASYG 250
                 33333333333333333333333332..122222222222222222222 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.1
                 XXXXXXXXXXX-----XXXXEEEE-TT.SS---------- CS
    Collagen   8 epGppGppGkrGepGeaGekGekGpaG.ekGppGaaGkpG 46 
                 +    G+ G  Ge G  G+ G++G+   + G++G +G++G
  EFC39059.1 280 RG---GKIGICGEFGVGGKGGSAGKGLlKMGRHGRQGSNG 316
                 11...22222222222222222221101112222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1025 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       695  (0.038764); expected 358.6 (0.02)
Passed bias filter:                      440  (0.0245412); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.81u 0.34s 00:00:01.15 Elapsed: 00:00:00.54
# Mc/sec: 5697.34
//
Query:       EFC39060.1  [L=990]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.5e-32  110.3   0.5    6.5e-06   26.0   0.0    6.5  6  Kelch_5     Kelch motif
      1e-30  105.5   4.3    8.9e-06   25.6   0.1    6.3  6  Kelch_4     Galactose oxidase, central domain
    4.4e-26   90.3   5.8    4.6e-05   23.5   0.1    5.7  5  Kelch_6     Kelch motif
    2.3e-23   82.0   1.1    7.8e-05   22.9   0.0    7.0  7  Kelch_3     Galactose oxidase, central domain
    4.4e-23   80.6   0.0    0.00023   20.7   0.1    5.6  5  Kelch_1     Kelch motif
    8.9e-16   57.2   6.3    0.00089   19.1   0.0    5.8  5  Kelch_2     Kelch motif
  ------ inclusion threshold ------
      0.034   13.7   0.4       0.07   12.7   0.4    1.5  1  DUF1700     Protein of unknown function (DUF1700)
      0.046   13.6   0.2       0.11   12.4   0.2    1.6  1  F-box-like  F-box-like
       0.79   10.1   6.1        2.3    8.7   0.1    3.1  2  Syntaxin_2  Syntaxin-like protein
        1.4    9.0   4.1       0.45   10.6   0.2    2.1  2  DASH_Dad3   DASH complex subunit Dad3


Domain annotation for each model (and alignments):
>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   2.2e-08     4e-05       2      37 ..      83     115 ..      83     118 .. 0.91
   2 !   15.3   0.0     8e-06     0.014       1      38 [.     129     164 ..     129     167 .. 0.91
   3 !   26.0   0.0   3.6e-09   6.5e-06       2      41 ..     184     220 ..     183     221 .. 0.91
   4 !   15.1   0.0   9.3e-06     0.017       2      38 ..     232     268 ..     231     271 .. 0.89
   5 !   13.9   0.0   2.2e-05      0.04       2      42 .]     291     330 ..     291     330 .. 0.90
   6 !    8.1   0.0    0.0015       2.6       5      33 ..     355     384 ..     353     387 .. 0.78

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 2.2e-08
     Kelch_5   2 PppRaghcavtvsekiYvyGGkvgrdgsvsddvyvL 37 
                 Pp R gh++ ++++ +Y++GG++   g+ s+d++ L
  EFC39060.1  83 PPKRKGHSMTFWNNRLYLFGGYQ---GGHSNDLWFL 115
                 99*********************...7888888876 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 8e-06
     Kelch_5   1 iPppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLd 38 
                 +P+ R++h+++++ + ++v+GG +g   ++ +d+++ d
  EFC39060.1 129 LPVKRSNHSSAMYRNHLIVFGGDKG--TDLMNDMWIID 164
                 69**********************6..99999999865 PP

  == domain 3  score: 26.0 bits;  conditional E-value: 3.6e-09
     Kelch_5   2 PppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdlps 41 
                 P  R+ hc+++++ek+ ++GG++    s+ +d+y +d ++
  EFC39060.1 184 PKVRYAHCSCILNEKLMLFGGYS---TSYLNDLYEFDFKT 220
                 445********************...9*********9876 PP

  == domain 4  score: 15.1 bits;  conditional E-value: 9.3e-06
     Kelch_5   2 PppRaghcavtvs..ekiYvyGGkvgrdgsvsddvyvLd 38 
                 Pp R ++ + + +  ++++vyGG +g  ++  +dv+v++
  EFC39060.1 232 PPERCHFTMTAIPecSSLLVYGGSNG--ENNLNDVWVFN 268
                 88899999999987889********6..*********87 PP

  == domain 5  score: 13.9 bits;  conditional E-value: 2.2e-05
     Kelch_5   2 PppRaghcavtvs.ekiYvyGGkvgrdgsvsddvyvLdlpsf 42 
                 P+pR+ h+  + s + ++++GG v+   s  ++++ L l++f
  EFC39060.1 291 PCPRSKHACTKISrDTLLIHGGNVS--PSKDNNIWMLKLTGF 330
                 9**********988**********5..666699999999887 PP

  == domain 6  score: 8.1 bits;  conditional E-value: 0.0015
     Kelch_5   5 RaghcavtvsekiYvyGGkvg.rdgsvsdd 33 
                 R  h++ tv++ i ++GG+    +g++ +d
  EFC39060.1 355 REAHSMNTVETDIVIFGGFAPhVEGHYRND 384
                 789****************97666665444 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.1     5e-09   8.9e-06       2      48 ..      86     130 ..      85     131 .. 0.89
   2 !   13.9   0.0   2.2e-05      0.04      12      48 ..     142     183 ..     133     185 .. 0.77
   3 !   24.9   0.0   8.2e-09   1.5e-05       5      45 ..     190     230 ..     187     234 .. 0.82
   4 !   24.1   0.2   1.5e-08   2.7e-05       2      43 ..     235     276 ..     234     284 .. 0.91
   5 !   11.5   0.0   0.00013      0.23       1      24 [.     293     316 ..     293     329 .. 0.85
   6 ?    0.3   0.0      0.42   7.5e+02       5      20 ..     358     372 ..     357     375 .. 0.78

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 5e-09
     Kelch_4   2 RaghsatsipdgtiylfGGrgedgtllndlylldlstntWrrl...gslP 48 
                 R ghs+t + ++++ylfGG+++ g  +ndl++  l+ n+W++l   g lP
  EFC39060.1  86 RKGHSMTFW-NNRLYLFGGYQG-G-HSNDLWF--LEGNKWKKLdvqGVLP 130
                 889******.7***********.5.9******..*******996666665 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 2.2e-05
     Kelch_4  12 dgtiylfGGrgedgtllndlylldlstn....tWrrl..gslP 48 
                 ++ +++fGG  +   l+nd++++dls      +Wr++  ++ P
  EFC39060.1 142 RNHLIVFGGDKGT-DLMNDMWIIDLSKPesdmRWRKVipKNQP 183
                 677999******8.6**********887555688888775444 PP

  == domain 3  score: 24.9 bits;  conditional E-value: 8.2e-09
     Kelch_4   5 hsatsipdgtiylfGGrgedgtllndlylldlstntWrrl...g 45 
                 h+++ + + ++ lfGG+++  + lndly +d++t  W+++    
  EFC39060.1 190 HCSCIL-NEKLMLFGGYST--SYLNDLYEFDFKTLLWSPIsvnD 230
                 777777.689*********..59****************97743 PP

  == domain 4  score: 24.1 bits;  conditional E-value: 1.5e-08
     Kelch_4   2 Raghsatsipd.gtiylfGGrgedgtllndlylldlstntWrr 43 
                 R+++++t+ip   ++ ++GG +++   lnd+++++ s  tW+ 
  EFC39060.1 235 RCHFTMTAIPEcSSLLVYGGSNGE-NNLNDVWVFNRSFCTWSL 276
                 99*******887************.6*********99999975 PP

  == domain 5  score: 11.5 bits;  conditional E-value: 0.00013
     Kelch_4   1 pRaghsatsipdgtiylfGGrged 24 
                 pR  h++t i ++t+ ++GG  ++
  EFC39060.1 293 PRSKHACTKISRDTLLIHGGNVSP 316
                 899*****************7766 PP

  == domain 6  score: 0.3 bits;  conditional E-value: 0.42
     Kelch_4   5 hsatsipdgtiylfGG 20 
                 hs+  +   +i++fGG
  EFC39060.1 358 HSMNTV-ETDIVIFGG 372
                 667777.479999*** PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.1   2.6e-08   4.6e-05       2      42 ..      86     122 ..      85     128 .. 0.90
   2 !   19.1   0.0   6.5e-07    0.0012       2      43 ..     133     177 ..     132     185 .. 0.84
   3 !   23.4   0.0   2.8e-08     5e-05       2      44 ..     187     227 ..     186     236 .. 0.89
   4 !   17.0   0.2     3e-06    0.0053       2      44 ..     235     278 ..     234     284 .. 0.88
   5 ?    5.4   0.0     0.014        25       2      21 ..     355     374 ..     354     391 .. 0.84

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 2.6e-08
     Kelch_6   2 raghslvsvggkiYifGGytdsspylnkvwvydpetksWeq 42 
                 r+ghs++ +++++Y+fGGy +   ++n++w++  e ++W++
  EFC39060.1  86 RKGHSMTFWNNRLYLFGGYQG--GHSNDLWFL--EGNKWKK 122
                 89*****************98..6******99..6788876 PP

  == domain 2  score: 19.1 bits;  conditional E-value: 6.5e-07
     Kelch_6   2 raghslvsvggkiYifGGytdsspylnkvwvyd...pe.tksWeql 43 
                 r  hs++ + +++ +fGG ++ +   n++w++d   pe +++W+++
  EFC39060.1 133 RSNHSSAMYRNHLIVFGGDKG-TDLMNDMWIIDlskPEsDMRWRKV 177
                 789******************.9**********6664424578764 PP

  == domain 3  score: 23.4 bits;  conditional E-value: 2.8e-08
     Kelch_6   2 raghslvsvggkiYifGGytdsspylnkvwvydpetksWeqlp 44 
                 r++h +++ ++k+++fGGy+   +yln+++ +d++t  W++++
  EFC39060.1 187 RYAHCSCILNEKLMLFGGYST--SYLNDLYEFDFKTLLWSPIS 227
                 7899***************98..7****************987 PP

  == domain 4  score: 17.0 bits;  conditional E-value: 3e-06
     Kelch_6   2 raghslvsvgg..kiYifGGytdsspylnkvwvydpetksWeqlp 44 
                 r++++++++ +  ++ ++GG+++ ++ ln+vwv++ + ++W+ l+
  EFC39060.1 235 RCHFTMTAIPEcsSLLVYGGSNG-ENNLNDVWVFNRSFCTWSLLQ 278
                 78899988775449*********.9*****************997 PP

  == domain 5  score: 5.4 bits;  conditional E-value: 0.014
     Kelch_6   2 raghslvsvggkiYifGGyt 21 
                 r +hs+ +v   i+ifGG  
  EFC39060.1 355 REAHSMNTVETDIVIFGGFA 374
                 568***************85 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       3.1   5.5e+03      37      47 ..      82      92 ..      72      93 .. 0.87
   2 !   13.1   0.0     5e-05     0.089       1      47 [.      95     139 ..      95     141 .. 0.90
   3 !   12.5   0.0   7.9e-05      0.14       2      47 ..     143     192 ..     142     194 .. 0.90
   4 !   22.9   0.0   4.4e-08   7.8e-05       2      49 .]     197     243 ..     196     243 .. 0.93
   5 !   18.9   0.1   7.7e-07    0.0014       4      47 ..     249     300 ..     247     302 .. 0.77
   6 ?    4.9   0.0     0.018        33       2      26 ..     305     327 ..     304     350 .. 0.83
   7 ?    0.5   0.0      0.45   8.1e+02       2      22 ..     366     386 ..     365     400 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 3.1
     Kelch_3 37 lppaRaghaat 47
                +pp R gh++t
  EFC39060.1 82 CPPKRKGHSMT 92
                699*******9 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 5e-05
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaei...aslppaRaghaat 47 
                 ++rly+fGG+    + ++nd++ +  +  +W+++   + lp  R++h+++
  EFC39060.1  95 NNRLYLFGGYQ---GGHSNDLWFLEGN--KWKKLdvqGVLPVKRSNHSSA 139
                 79*********...9*******98877..9998888999999*****985 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 7.9e-05
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtn....tWaei..aslppaRaghaat 47 
                 + l +fGG    g+d  nd++ +dl+++     W+++   + pp  ++++++
  EFC39060.1 143 NHLIVFGGDK--GTDLMNDMWIIDLSKPesdmRWRKVipKNQPPKVRYAHCS 192
                 5599******..*************9999999***9999999**88888875 PP

  == domain 4  score: 22.9 bits;  conditional E-value: 4.4e-08
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWaei..aslppaRaghaatai 49 
                 ++l +fGG+    + +lnd+y++d+ t  W  i   + pp R+++++tai
  EFC39060.1 197 EKLMLFGGYS---TSYLNDLYEFDFKTLLWSPIsvNDAPPERCHFTMTAI 243
                 67889*****...9999**************99889************97 PP

  == domain 5  score: 18.9 bits;  conditional E-value: 7.7e-07
     Kelch_3   4 lyifGGlgddgqdrlndvyvydldtntWaei..........aslppaRaghaat 47 
                 l+++GG +  g+++lndv+v++ +  tW  +          +  p +R+ ha+t
  EFC39060.1 249 LLVYGGSN--GENNLNDVWVFNRSFCTWSLLqmntdvgwqkGIKPCPRSKHACT 300
                 89******..**************999993333444555556667788877776 PP

  == domain 6  score: 4.9 bits;  conditional E-value: 0.018
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydl 26 
                 d+l+i+GG+   +   +n+ +++ l
  EFC39060.1 305 DTLLIHGGNV--SPSKDNNIWMLKL 327
                 89********..99999****9988 PP

  == domain 7  score: 0.5 bits;  conditional E-value: 0.45
     Kelch_3   2 drlyifGGlgddgqdrl..ndvy 22 
                 d ++ifGG+ + + +++  nd++
  EFC39060.1 366 D-IVIFGGFAP-HVEGHyrNDTW 386
                 4.89****995.43333458887 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.0   4.5e-05     0.081       2      27 ..      86     110 ..      85     122 .. 0.86
   2 !   15.7   0.0   4.7e-06    0.0084       2      36 ..     133     167 ..     132     170 .. 0.95
   3 !   20.6   0.0   1.4e-07   0.00025       2      42 ..     187     226 ..     187     227 .. 0.96
   4 !   20.7   0.1   1.3e-07   0.00023      14      41 ..     249     276 ..     234     278 .. 0.85
   5 ?    3.6   0.0     0.028        51       5      22 ..     358     375 ..     355     387 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.5e-05
                 BBSEEEEEETTEEEEEEEBCSSSBEE CS
     Kelch_1   2 ragagavvvggkiYviGGsdggnals 27 
                 r g++++  ++++Y +GG+ g   ++
  EFC39060.1  86 RKGHSMTFWNNRLYLFGGYQG-GHSN 110
                 89*****************99.4444 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 4.7e-06
                 BBSEEEEEETTEEEEEEEBCSSSBEEEEEEEETTT CS
     Kelch_1   2 ragagavvvggkiYviGGsdggnalssvevyDpet 36 
                 r++++++  ++++ v+GG  g   +++ +++D+ +
  EFC39060.1 133 RSNHSSAMYRNHLIVFGGDKGTDLMNDMWIIDLSK 167
                 9*******************************976 PP

  == domain 3  score: 20.6 bits;  conditional E-value: 1.4e-07
                 BBSEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEEE CS
     Kelch_1   2 ragagavvvggkiYviGGsdggnalssvevyDpetntWrel 42 
                 r+ ++++ +++k+  +GG++  ++l++++ +D++t  W+++
  EFC39060.1 187 RYAHCSCILNEKLMLFGGYST-SYLNDLYEFDFKTLLWSPI 226
                 7899****************9.****************997 PP

  == domain 4  score: 20.7 bits;  conditional E-value: 1.3e-07
                 EEEEEEBCSSSBEEEEEEEETTTTEEEE CS
     Kelch_1  14 iYviGGsdggnalssvevyDpetntWre 41 
                 + v GGs+g n l++v+v++    tW+ 
  EFC39060.1 249 LLVYGGSNGENNLNDVWVFNRSFCTWSL 276
                 89************************96 PP

  == domain 5  score: 3.6 bits;  conditional E-value: 0.028
                 EEEEEETTEEEEEEEBCS CS
     Kelch_1   5 agavvvggkiYviGGsdg 22 
                 +++ +v + i ++GG+  
  EFC39060.1 358 HSMNTVETDIVIFGGFAP 375
                 8999***********987 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0     5e-07   0.00089       4      36 ..      88     121 ..      85     126 .. 0.89
   2 !    5.6   0.0    0.0094        17       2      38 ..     133     166 ..     132     180 .. 0.76
   3 !   14.1   0.0     2e-05     0.036       2      45 ..     187     226 ..     186     228 .. 0.94
   4 !   10.4   0.1   0.00028      0.51       7      36 ..     240     268 ..     234     278 .. 0.77
   5 !    6.4   0.0    0.0053       9.5       5      37 ..     358     390 ..     355     392 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 5e-07
     Kelch_2   4 ghsssvpggkiyvvGGa.htdnpnlsssdvhvld 36 
                 ghs++ +++++y++GG+ +++ ++l++   + + 
  EFC39060.1  88 GHSMTFWNNRLYLFGGYqGGHSNDLWFLEGNKWK 121
                 9****************99999999999988875 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0094
     Kelch_2   2 rgghsssvpggkiyvvGGahtdnpnlsssdvhvldle 38 
                 r+ hss++ ++ ++v+GG     + +  +d+++ dl+
  EFC39060.1 133 RSNHSSAMYRNHLIVFGGD---KGTDLMNDMWIIDLS 166
                 899***************8...555555555555555 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 2e-05
     Kelch_2   2 rgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 r+ h s+ ++ k+ ++GG+    + ++ +d++ +d+++  W++ 
  EFC39060.1 187 RYAHCSCILNEKLMLFGGY----STSYLNDLYEFDFKTLLWSPI 226
                 899****************....***************999985 PP

  == domain 4  score: 10.4 bits;  conditional E-value: 0.00028
     Kelch_2   7 ssvp..ggkiyvvGGahtdnpnlsssdvhvld 36 
                 ++ +  ++ ++v+GG+   n+    +dv+v++
  EFC39060.1 240 MTAIpeCSSLLVYGGS---NGENNLNDVWVFN 268
                 333355999*******...***********98 PP

  == domain 5  score: 6.4 bits;  conditional E-value: 0.0053
     Kelch_2   5 hsssvpggkiyvvGGahtdnpnlsssdvhvldl 37 
                 hs+ +++  i+++GG+ ++  +++ +d ++ d 
  EFC39060.1 358 HSMNTVETDIVIFGGFAPHVEGHYRNDTWWGDI 390
                 78889999************9999999999997 PP

>> DUF1700  Protein of unknown function (DUF1700)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.4   3.9e-05      0.07      16     112 ..     764     862 ..     754     921 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.9e-05
     DUF1700  16 klpeeekkdilsdYeehFesgkeeGksEeeivkeLgdPkeIakeltaesaikkaekkkslknvskailavigLsllnlilvlipliv..iislvlsllv 112
                 k  ++e+ d++++Y      +k +G    + +++  +  eIa+  ++++aik  e+k       + +   +gL +l li+ +i++++  ++s+v+ +++
  EFC39060.1 764 KSGKQERMDVIYKYCRLLMDNKMDGIRRFDGIRKAQKTSEIANIEKQKQAIKDSEQKLLGLIALTVVSFLLGLDFLRLIMRMIAYLIyfVASFVVPIII 862
                 55789**************************************99999999988776544444444445679999999887777655113334444444 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.2   6.3e-05      0.11      14      44 ..     710     740 ..     704     740 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.3e-05
  F-box-like  14 syLpps.dLlrlalVCrrWrrvaldtplLWrr 44 
                  yL++  d+lrl++VC   + + +d+ +LWr+
  EFC39060.1 710 VYLEDVfDILRLSQVCQASNAAFRDP-YLWRN 740
                 5885445**************98877.***95 PP

>> Syntaxin_2  Syntaxin-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.3      0.11     2e+02      61      86 ..     503     528 ..     489     542 .. 0.72
   2 ?    8.7   0.1    0.0013       2.3      26      62 ..     928     964 ..     924     972 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.11
  Syntaxin_2  61 nsssdsqqklqkekLkkdfkealqeF 86 
                 ns+s+sq+  + ekL+ +++e +q++
  EFC39060.1 503 NSDSTSQKVNILEKLVVELSETVQQL 528
                 33333355558999999999988886 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0013
  Syntaxin_2  26 kdteelreklhelieeinelikktnellkklsqldns 62 
                 k+   l+e++ +++ ei  l k+t+e++++l++++++
  EFC39060.1 928 KQYVALNENISSIRREIDCLEKETSEKVEQLMKISRK 964
                 567789**************************99876 PP

>> DASH_Dad3  DASH complex subunit Dad3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.5       3.7   6.6e+03      16      40 ..     515     539 ..     509     552 .. 0.58
   2 ?   10.6   0.2   0.00025      0.45       4      50 ..     922     967 ..     921     969 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 3.7
   DASH_Dad3  16 aenlktLaselkeLasnsteeildg 40 
                 ++ + +L++++++L+ + ++e+ + 
  EFC39060.1 515 EKLVVELSETVQQLTISLSTETKRR 539
                 4555668888888877644444333 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00025
   DASH_Dad3   4 leqevLdeYerLaenlktLaselkeLasnsteeildgLReLErkigl 50 
                 +e+ v ++Y  L+en+ ++  e++ L ++ t+e +++L ++ rki l
  EFC39060.1 922 VERRVKKQYVALNENISSIRREIDCLEKE-TSEKVEQLMKISRKIPL 967
                 588999*****************999998.55567889999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (990 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1440  (0.0803168); expected 358.6 (0.02)
Passed bias filter:                      588  (0.032796); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.85u 0.34s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 5626.81
//
Query:       EFC39061.1  [L=308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-15   57.2   0.4    1.7e-15   57.2   0.4    1.8  2  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1      0.41   7.4e+03      33      54 ..      14      34 ..      11      50 .. 0.62
   2 !   57.2   0.4   9.3e-20   1.7e-15       9     108 ..      98     195 ..      92     198 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.41
                H-HHHHHHHTSTTTTTCCCEEE CS
         BTB 33 rSpyFkalftskeieessvsei 54
                +S  F++l  ++++ +++++ i
  EFC39061.1 14 SSYSFEKLRYEDYMGKKKQK-I 34
                46668888888866665554.2 PP

  == domain 2  score: 57.2 bits;  conditional E-value: 9.3e-20
                 TTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-...CGGGHHHHHHHHHHHT-HHHHHHHH CS
         BTB   9 elcDvtlvvgdgkefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleit...seenleelLaaadllqiprlkkace 104
                   +Dv++v+  ++++ +hk++L +rSp+Fk+lf+     + +   i ++ ++  ++e l+++iYtg+++++     +++ ++++aa llq++ l++++ 
  EFC39061.1  98 RSSDVAIVMA-DSKVLCHKIILLCRSPVFKKLFEMY--PDCK--LISIPSIKKPIMEVLIQYIYTGQIDNEhliIHDYVIDVFEAAILLQMKPLIEVLA 191
                 569*******.6***********************9..5666..6899***********************999789*******************999 PP

                 HHHH CS
         BTB 105 eflk 108
                 ++++
  EFC39061.1 192 KIVS 195
                 9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       873  (0.0486921); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.34s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1740.97
//
Query:       EFC39062.1  [L=888]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (888 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       856  (0.0477439); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 5336.13
//
Query:       EFC39063.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.005   17.0   0.9        4.3    7.6   0.1    3.1  3  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
  ------ inclusion threshold ------
      0.044   14.3   0.1        4.2    8.0   0.0    3.2  3  TPR_19    Tetratricopeptide repeat
      0.064   13.4   0.8         23    5.4   0.0    4.3  4  TPR_2     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.83     5e+03      38      60 ..     236     257 ..     234     265 .. 0.60
   2 !    6.4   0.0    0.0018        11      40      77 ..     336     373 ..     332     378 .. 0.84
   3 !    7.6   0.1   0.00072       4.3      23      50 ..     396     424 ..     379     439 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.83
                 -HHHHHHHHHCTSHHHC-HHHHH CS
      ANAPC3  38 qykrAyellrkaklnskslgcry 60 
                  +++A++l+++++l + s++  y
  EFC39063.1 236 SFEKALRLYENSEL-KDSKELYY 257
                 57777777777733.34444444 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0018
                 HHHHHHHHCTSHHHC-HHHHHHHHHHHHHTT-HHHHHH CS
      ANAPC3  40 krAyellrkaklnskslgcrylfAqcllkLkkyeeAia 77 
                 +rA++ ++k+ ++ +  +  y +A +l+ ++k+ eAi+
  EFC39063.1 336 ERAIKHFKKSFEKVREAKTVYAYAGALFLMEKVPEAIN 373
                 58888899998889999999999999999999999987 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.00072
                 HHHHHHHHHHHHHTT-HHHHHHHHHCT.S CS
      ANAPC3  23 pedayllAlclylngqykrAyellrka.k 50 
                  e +  ++lcly+n  + +A ++l+++ k
  EFC39063.1 396 KETTVNYSLCLYHNHSFSQAKDILSETlK 424
                 55666799****************99844 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       0.3   1.8e+03       7      34 ..     237     265 ..     235     280 .. 0.65
   2 ?    1.6   0.0     0.069   4.1e+02       8      46 ..     336     373 ..     333     391 .. 0.76
   3 ?    8.0   0.0    0.0007       4.2      33      59 ..     404     430 ..     395     437 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.3
      TPR_19   7 yaeAlalleqa.lqedpknaearllLAea 34 
                 ++ Al+l+e+  l+++ +  ++  + A++
  EFC39063.1 237 FEKALRLYENSeLKDSKELYYVHGDIAIL 265
                 78999999997566665555555555555 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.069
      TPR_19   8 aeAlalleqalqedpknaearllLAeallalgqldeAea 46 
                 ++A++++++ +++  +   + + +A al+ +  + eA++
  EFC39063.1 336 ERAIKHFKKSFEKVREAKTVYA-YAGALFLMEKVPEAIN 373
                 5799999999888775555555.9999999999999876 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0007
      TPR_19  33 eallalgqldeAealLdalpeedpdda 59 
                  +l+ +  + +A+++L++ ++e+pd+a
  EFC39063.1 404 LCLYHNHSFSQAKDILSETLKEFPDEA 430
                 599999*******************75 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.0    0.0038        23      20      33 ..     233     246 ..     231     247 .. 0.85
   2 ?    0.7   0.1      0.13   7.7e+02      18      29 ..     336     347 ..     336     351 .. 0.84
   3 ?   -2.1   0.1         1     6e+03       5      21 ..     356     372 ..     352     375 .. 0.73
   4 ?    1.6   0.0     0.064   3.9e+02       6      33 ..     401     428 ..     400     429 .. 0.91

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0038
       TPR_2  20 AleafekAleldPn 33 
                  ++ fekAl+l++n
  EFC39063.1 233 GIKSFEKALRLYEN 246
                 5899*******987 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.13
       TPR_2  18 eeAleafekAle 29 
                 e+A+++f+k+ e
  EFC39063.1 336 ERAIKHFKKSFE 347
                 68******9866 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1
       TPR_2   5 ynlGlayyklgdyeeAl 21 
                 y+ + a++ + +  eA+
  EFC39063.1 356 YAYAGALFLMEKVPEAI 372
                 66777888888888887 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.064
       TPR_2   6 nlGlayyklgdyeeAleafekAleldPn 33 
                 n  l++y++  + +A++ + + l+  P+
  EFC39063.1 401 NYSLCLYHNHSFSQAKDILSETLKEFPD 428
                 56789******************99997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1463  (0.0815996); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 2878.24
//
Query:       EFC39064.1  [L=138]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (138 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1600  (0.0892409); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 865.58
//
Query:       EFC39065.1  [L=552]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0052   17.2  22.2       0.34   11.4   0.1    8.1  6  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.7     0.056     1e+03      16      29 ..      65      80 ..      22      97 .. 0.65
   2 ?    0.3   0.1      0.06   1.1e+03      19      30 ..     129     140 ..     103     149 .. 0.80
   3 ?    1.8   0.8      0.02   3.6e+02      13      30 ..     245     264 ..     238     276 .. 0.68
   4 !   11.4   0.1   1.9e-05      0.34       1      30 [.     278     308 ..     278     357 .. 0.94
   5 !    5.0   0.0     0.002        36      13      32 ..     376     394 ..     370     401 .. 0.79
   6 !    2.9   0.0    0.0086   1.5e+02      19      30 ..     402     413 ..     398     422 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.056
                -S-..HHH-TT--EEE CS
       LRR_4 16 ipl..leklpnLkeLd 29
                i+   ++k+ +L+ L+
  EFC39065.1 65 IDVkfISKFEKLQNLS 80
                3333233455555555 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.06
                 HHH-TT--EEE- CS
       LRR_4  19 leklpnLkeLdL 30 
                 le+++ Lk+L+L
  EFC39065.1 129 LEQMKTLKHLTL 140
                 667999999988 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.02
                 --E-S-.HHH.-TT--EEE- CS
       LRR_4  13 ltdipl.lek.lpnLkeLdL 30 
                 l + ++ l++ ++nLk L L
  EFC39065.1 245 LLKNDFlLGNtFDNLKRLEL 264
                 44466766666899999888 PP

  == domain 4  score: 11.4 bits;  conditional E-value: 1.9e-05
                 SS--EEE--SS---.E-S-HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdL 30 
                 p+Le++++sn+  + +i+++++  +Lk+L L
  EFC39065.1 278 PSLEYVHCSNCSFRsSIEFFSNSRKLKSLVL 308
                 79*****************999999*99988 PP

  == domain 5  score: 5.0 bits;  conditional E-value: 0.002
                 --E-S-HHH-TT--EEE-.- CS
       LRR_4  13 ltdiplleklpnLkeLdLsg 32 
                 l d++ +e + +L++L+L g
  EFC39065.1 376 LVDLSAIEEMSSLEYLNL-G 394
                 557888888*********.4 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.0086
                 HHH-TT--EEE- CS
       LRR_4  19 leklpnLkeLdL 30 
                 + kl+nLk+L +
  EFC39065.1 402 FDKLTNLKYLEI 413
                 557*******98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (552 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       475  (0.0264934); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.47
# Mc/sec: 3528.12
//
Query:       EFC39066.1  [L=614]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.19   11.6   0.2       0.34   10.8   0.2    1.3  1  Sigma70_ner  Sigma-70, non-essential region


Domain annotation for each model (and alignments):
>> Sigma70_ner  Sigma-70, non-essential region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.2   1.9e-05      0.34      99     160 ..     456     517 ..     450     542 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 1.9e-05
  Sigma70_ner  99 kkyekareelseefkefrLtpkqidrLveqlrslvervraqEreimrlcverakmprkdFik 160
                  k+++    +ls+++ +f Ltpkq ++    ++++  ++r+ E   m+l+  + +++++ F+k
   EFC39066.1 456 KQSKIISSKLSQHLDSFNLTPKQLESANCVVKTITSQIRNVEMMAMSLLQLSNQYEKDLFVK 517
                  5566667899**************************************99999999999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (614 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 4026.87
//
Query:       EFC39067.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      7e-20   70.5   6.8    2.9e-10   39.7   0.0    5.3  4  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.0     4e-10   7.2e-06      22      48 ..     143     169 ..     142     170 .. 0.95
   2 !   39.7   0.0   1.6e-14   2.9e-10       1      47 [.     172     218 ..     172     220 .. 0.93
   3 ?    0.9   0.3     0.021   3.8e+02      26      45 ..     323     342 ..     295     345 .. 0.74
   4 !    2.9   0.1    0.0051        91      25      42 ..     378     395 ..     346     416 .. 0.70

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 4e-10
     DUF4116  22 eLknDkeivlkAvkqngtalsyaseeL 48 
                 e++n++e++++ v++ng  l+ya+++L
  EFC39067.1 143 EMRNNREFMMESVQKNGLLLYYAHPDL 169
                 79***********************98 PP

  == domain 2  score: 39.7 bits;  conditional E-value: 1.6e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 D E+ lea+++n sa++y++ +L++D +++++A++++g+++ y+  e
  EFC39067.1 172 DQELLLEAIRNNVSAFQYVPYNLRRDEQFLKRAIEKCGDVFLYLTGE 218
                 669****************************************9755 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.021
     DUF4116  26 DkeivlkAvkqngtalsyas 45 
                 D e ++kA+++n ++ +y+s
  EFC39067.1 323 DNEAIIKALRSNMIISNYLS 342
                 88999*****9988777776 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.0051
     DUF4116  25 nDkeivlkAvkqngtals 42 
                 ++++ v + vk++++  +
  EFC39067.1 378 SNRDNVRALVKRYPFLAE 395
                 488889999998887333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       617  (0.0344135); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.56
# Mc/sec: 2660.86
//
Query:       EFC39068.1  [L=220]
Description: hypothetical protein NAEGRDRAFT_81396 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
     0.0089   16.5   0.1      0.023   15.2   0.1    1.6  1  Med11      Mediator complex protein
  ------ inclusion threshold ------
          2    9.1   5.2        1.7    9.3   0.3    2.1  2  AATF-Che1  Apoptosis antagonizing transcription factor


Domain annotation for each model (and alignments):
>> Med11  Mediator complex protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.1   2.6e-06     0.023      13      70 ..      85     139 ..      76     141 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.6e-06
       Med11  13 dIvslLesasealkaLskppeqepaseseeaqkeafkaatstffstLssvdvrLrrqI 70 
                 ++  lLe+  + +++L+k   ++ ++ s +++ + +k++ s+++ tLs++++++++ I
  EFC39068.1  85 RVLYLLELGMTFIESLTK---ATRENMSVDEAISDCKDNISDYYDTLSEIKTNMSKLI 139
                 677899999999****99...9999999**************************9866 PP

>> AATF-Che1  Apoptosis antagonizing transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.7     0.035   3.1e+02      65     113 ..       6      54 ..       2      72 .. 0.55
   2 ?    9.3   0.3   0.00019       1.7      43     114 ..     102     173 ..      92     207 .. 0.66

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.035
   AATF-Che1  65 lleslleLreelleqneikklaeskeeeekkkskrkrkkkkkeetslee 113
                 +l s  +L  +l+eqn++k+  ++++++  ++++ + +++++ + ++e+
  EFC39068.1   6 TLISSSDLNGNLMEQNQLKEEIQNDSASVMTGNEDNMDTNDDGAVEIES 54 
                 5666678888899999955444444445555555555555444444433 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00019
   AATF-Che1  43 eflesseefeealeeaekalkklleslleLreelleqne.ikkla..eskeeeekkkskrkrkkkkkeetsleel 114
                 + ++++ +++ea++++++++++ +++l e+++++   ++ i+ ++  +  + e +  s+rkr + ++++ ++ ++
  EFC39068.1 102 KATRENMSVDEAISDCKDNISDYYDTLSEIKTNM---SKlICMSSfhSPLNYEGSLYSERKRIEINNKKAKILKF 173
                 4444578899************************...33343333554444444445555555554444444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.27s 00:00:00.71 Elapsed: 00:00:00.43
# Mc/sec: 1532.03
//
Query:       EFC39069.1  [L=427]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-27   96.5  19.9    2.2e-27   95.7  19.9    1.4  1  Got1      Got1/Sft2-like family
  ------ inclusion threshold ------
      0.024   15.0   0.6      0.056   13.8   0.2    1.7  1  DUF5024   Domain of unknown function (DUF5024)


Domain annotation for each model (and alignments):
>> Got1  Got1/Sft2-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.7  19.9   2.5e-31   2.2e-27       1     112 [.     308     419 ..     308     420 .. 0.95

  Alignments for each domain:
  == domain 1  score: 95.7 bits;  conditional E-value: 2.5e-31
        Got1   1 GvllfllsllglpllflkprkFallytlGnilflastafLiGpkkqlkkmfskerliativyllsllltLyaalvlkstlltllfvivqllallwylls 99 
                 G+l++l++l +lp ++++   Fa++yt+Gn+l+l+st+fL+Gp +qlk+m ++er i ++++++s++ltL++ +++  +++++++vivq+++l+wy++s
  EFC39069.1 308 GLLCILIALGFLPSILFASGAFAFFYTFGNLLCLTSTLFLVGPAAQLKNMSKPERAIPSALFVGSMILTLLCVFFMPLAIFIIILVIVQTVSLAWYVVS 406
                 789999997777888888899****************************************************************************** PP

        Got1 100 yiPggrsalkkvl 112
                 yiP+++s+l +v+
  EFC39069.1 407 YIPFAQSILGMVF 419
                 ********99887 PP

>> DUF5024  Domain of unknown function (DUF5024)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.2   6.2e-06     0.056      17      65 ..      26      74 ..      14      85 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 6.2e-06
     DUF5024 17 vaitsvtkrdPkTrkVvkvVksfsvkdeglgkelkeAFerdeeeaekai 65
                ++ +s++  d    kV   + sfs+  + ++k+l + F++de +a ++ 
  EFC39069.1 26 SSNNSIIDSDAVSNKVNEWIGSFSTWTSSVQKSLENTFKQDETTATTTT 74
                567899999************************************9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (427 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2209  (0.123208); expected 358.6 (0.02)
Passed bias filter:                      607  (0.0338558); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.27s 00:00:00.86 Elapsed: 00:00:00.42
# Mc/sec: 3061.61
//
Query:       EFC39070.1  [L=461]
Description: aspartyl-tRNA synthetase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.6e-30  105.1   0.2    6.8e-30  104.2   0.2    1.4  1  tRNA-synt_2      tRNA synthetases class II (D, K and N)
    8.1e-05   22.5   0.1    0.00015   21.7   0.1    1.4  1  tRNA_anti-codon  OB-fold nucleic acid binding domain


Domain annotation for each model (and alignments):
>> tRNA-synt_2  tRNA synthetases class II (D, K and N)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.2   0.2   7.5e-34   6.8e-30       6     312 ..     149     450 ..     144     452 .. 0.88

  Alignments for each domain:
  == domain 1  score: 104.2 bits;  conditional E-value: 7.5e-34
                  HHTHHHHCCSHHHHHHHHHHHHHHHHHHHHHHHTT-EE----SEESS--SSSS--EEEEETTT.TEEE....-E-S-SHHHHHHHHHCTHSEEEEEEE CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxx RF
  tRNA-synt_2   6 lknryldlrtekvskvlrlrstvtkavrkyleengfieietPiLsksdteegarlFkvksrekekeff....aLtqspqlylellivagidrvfqiar 99 
                   ++ry+ lr++ ++++++l+s + + + +y+ +++f+ei+tP ++k+++ ++   F+        ++f     Lt s+ l+ +l i +g+drvf+i+ 
   EFC39070.1 149 HTKRYVSLRHSFMHHIFKLQSLIGRKFCEYMYSKDFTEIHTPHIVKNQSDNNISSFTF-------DYFgnsvELTTSSHLHQQLAIHGGLDRVFEISC 239
                  579*******************************************************.......77778889************************* PP

                  EE--S--BTTB-S-CEEEEEEEEET-SCHH.HHHHHHHHHHHHHHHHHHCSCCCCCHTTTTTS...EE-SSS.-EEEEHHHHHHHHHTS-SS--HHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxx RF
  tRNA-synt_2 100 aFRaEdsrtdrhlaEFtqieaemsfieeed.imqvleelikslvkevlessakdiefvirrns...kdlkkp.fkrltykeaieklneigkdldkade 192
                  aF +    t  hl+E t++++ m ++++ + +++v++el++++++e+ e   +++e   ++ns   ++lkk+ +  lt+kea   l  ++    +++ 
   EFC39070.1 240 AFEKHHGCTHVHLNEKTTLNFGMTIASHYHeVISVVKELLNYIIDEISEY--EGLEVIAKHNSrglEKLKKTeILELTFKEADALLIANCS---ENEF 332
                  ****999******************998888****************544..455555555555578999988********9888654433...3333 PP

                  HHHHHHS--SEEEEEEEB..........GGGSTTCBBBSTTSTTBBSEEEEEETTEEEEEEEEB--SHHHHHHHHHHCCHHSSSGGGGHHHHHHHHCT CS
                  xxxxxxxxxxxxxxxxxx..........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  tRNA-synt_2 193 ralvkkeknepvfvtdfP..........aelkpFyarkeeddkkltesyDllingvElvgGslRiedpeeleeklkskgldeeaeekfswylealeyG 280
                     +   + +  +  d+           +e+  F +++++   k  +++ +li+g+ ++ G + i+d+e+l+++ + +  d         ++ al+yG
   EFC39070.1 333 GGFMA-LREVASYFKDYTdiliiqnsahEEVGCFEMPSSTG--KGFNNFIILIRGIVVGRGCQYIHDEELLKHQVRCHAPD---------LVSALKYG 418
                  33333.46677777888888888888899999****99988..78999*************************99999888.........******** PP

                  --SEEEEEEEHHHHHHHHCT-SSGGGCSSS-X CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  tRNA-synt_2 281 apphgGlglGldRlvmlllgsesIrdviaFPk 312
                  a p gG+ + l+ ++m +l+++++r +++FP+
   EFC39070.1 419 AQPCGGCSIDLELFLMQFLQLSNVRFTSLFPR 450
                  *******************************8 PP

>> tRNA_anti-codon  OB-fold nucleic acid binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.1   1.7e-08   0.00015       3      74 ..      44     124 ..      42     126 .. 0.91

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 1.7e-08
                      EEEEEEEEEEEEETTEEEEEEEETTEEEEEEEET.....HHHHHHHTTS-TTSEEEEEEEEEECTTS......SEEEEEEEEE CS
  tRNA_anti-codon   3 vaGrvtsisdrsggkvifidlrDgtgriqvvlfr.....eeatklaenlkeGdvvrvtGrvkrrpgg......elelkveeie 74 
                      + +r +++   ++gk++f+ lr ++ +iq+ +        e+ k+   ++ +++v+v G +  r+ +      elel  +ei 
       EFC39070.1  44 LIARASRV--VKKGKLCFVRLRRNSHSIQACFLAkndqeREMVKYIGGIPHESIVEVVGIIVMRKSKsnetvsELELEMKEIY 124
                      66778888..99**********************99999999999999****************88888999*9999988886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (461 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       652  (0.0363657); expected 358.6 (0.02)
Passed bias filter:                      395  (0.0220313); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.26s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2960.94
//
Query:       EFC39071.1  [L=316]
Description: hypothetical protein NAEGRDRAFT_82767 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.6e-10   40.2   0.0    9.5e-09   35.1   0.0    2.1  1  Epimerase       NAD dependent epimerase/dehydratase family
    1.5e-06   27.8   0.1     0.0095   15.4   0.0    2.4  3  GDP_Man_Dehyd   GDP-mannose 4,6 dehydratase
    0.00012   21.2   0.0    0.00048   19.2   0.0    1.9  1  3Beta_HSD       3-beta hydroxysteroid dehydrogenase/isomerase
    0.00071   19.2   0.0      0.013   15.0   0.0    2.1  2  NmrA            NmrA-like family
     0.0013   18.6   0.0     0.0018   18.2   0.0    1.2  1  NAD_binding_10  NAD(P)H-binding
     0.0023   18.1   0.0     0.0039   17.3   0.0    1.5  1  DapB_N          Dihydrodipicolinate reductase, N-terminus
  ------ inclusion threshold ------
      0.045   12.8   0.0       0.27   10.3   0.0    1.9  2  RmlD_sub_bind   RmlD substrate binding domain
       0.17   11.8   0.0       0.34   10.9   0.0    1.5  1  ADH_zinc_N      Zinc-binding dehydrogenase


Domain annotation for each model (and alignments):
>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.1   0.0   4.2e-12   9.5e-09       1     241 []       4     230 ..       4     230 .. 0.75

  Alignments for each domain:
  == domain 1  score: 35.1 bits;  conditional E-value: 4.2e-12
                 EEEETTTSHHHHHHHHHHHHCTSEEEEEES-STTTTCHHCHHCEEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHHHSHHHHHHHHTHHHHHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekgyevigldrlssasntarledlelveldltdrsalerlfkeeqpdavihlAavggvaassedpadfieknlqgtlnll 99 
                 +lV+Ga+G+iG  + +al+++g  v+g+ r ++ ++   +      e+  +  s+ e lf ee++  ++     + + + +   +++ +    +  + +
  EFC39071.1   4 VLVLGANGYIGLGVSQALQRNGFSVHGVIRSEKHEKLLWQS-----EITPLIISKAETLFTEEKFGKILEK--TSVIIDCIGLTEETDKFVQLLKDHSA 95 
                 79*****************************7777776666.....7777777778888888888888777..55555555554443333334555555 PP

                 HHHHHH.TCTEEEEEEEGGGGTSCSSSSBSTCSTTS--..--SSHHHHHHHHHHHHHHHHHHHHT-EEEEEEESEEESTTS-TTSTTSHHHHHHHHHHT CS
   Epimerase 100 eaarka.gvkrllflsSsevYGkdaeqpkeettltgpl..kpnspYaaaKlageklveayaaqyglnaiilrlfnlyGprngegevsrvipalirkile 195
                 e ++k+ g   ++f s   +YG+  +    et l++++  +p+         +e  + +    y l+++++r+  +yG+         +  ++  ki +
  EFC39071.1  96 ERLKKKlGRLLFVFTSGIMTYGNASS----ETFLDENVrpEPTHSWTEKRKNFEFELVNGEFNY-LDTCVIRPGFVYGKS----GGGIFTDYFNPKITQ 185
                 55555423336666666777887776....4444455533666666655555555555555555.**************9....788888889999999 PP

                 TSSSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT-STTEEEEES CS
   Epimerase 196 gkqevtllgdgtalRdflyveDvaeaillvlehvdagdkgeiyniG 241
                    ++ + g+ + ++ +++v+D+ ea+  v++  ++  +g+ +ni+
  EFC39071.1 186 DG-KLSIAGSPKKRWSWVHVDDLGEAYSKVVQVGRKLVSGQLFNIA 230
                 99.9*****************************999999*****96 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0   0.00018      0.41       1      34 [.       5      38 ..       5      53 .. 0.91
   2 ?   -3.1   0.0       1.8   3.9e+03     122     150 ..     105     134 ..      91     140 .. 0.73
   3 !   15.4   0.0   4.2e-06    0.0095     213     322 ..     191     297 ..     174     305 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00018
                   EEETTTSHHHHHHHHHHHHCT-CCEEEEEEESS- CS
  GDP_Man_Dehyd  1 LiTGiaGfiGsylaelLlekgyevhgivrrsssf 34
                   L+ G +G+iG  + + L ++g+ vhg++r +++ 
     EFC39071.1  5 LVLGANGYIGLGVSQALQRNGFSVHGVIRSEKHE 38
                   899*************************988764 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.8
                    SEEEEEEEGGGG-S-S.SSSB-TTS----- CS
  GDP_Man_Dehyd 122 vrfyqaStsEvYGkvq.evpqtEttpfyPr 150
                      f+++S    YG+++ e+  +E+ + +P+
     EFC39071.1 105 LLFVFTSGIMTYGNASsETFLDENVRPEPT 134
                    567788888899999746667888776665 PP

  == domain 3  score: 15.4 bits;  conditional E-value: 4.2e-06
                    ECTTTT-EEEEEEHHHHHHHHHHHHHCSS---EEE-TT-EEECHHCHHCCH.HCCCHHHHHH............TTGGCCCEECGG--SS--.... CS
  GDP_Man_Dehyd 213 ylGnldakRdwghvkDyveamwlmlqqdkpedyviatgethsvrefvelaf.lelgktiewegkgeeevgrakesgkvvvevdpkyfrpgev.... 303
                    + G  +++ +w hv+D  ea+ +++q +++    + +g+ +++ + ++     ++ ++i +++      +  +e++ +   ++p++   +      
     EFC39071.1 191 IAGSPKKRWSWVHVDDLGEAYSKVVQVGRK----LVSGQLFNIANPNDYPTyDRVRIEIAKQT----GWKPTTENEADSLLIEPVPQDNAGLvife 278
                    4588888999****************9984....77888999988888776134444554443....23333444445555556555554421222 PP

                    SB--B-THHHHHHH----S CS
  GDP_Man_Dehyd 304 dlllgdaskakeeLgWkpk 322
                    ++++++++ka e LgW+pk
     EFC39071.1 279 NTVMINPRKAIEVLGWEPK 297
                    6889**************8 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   2.2e-07   0.00048     110     272 ..     106     253 ..       5     258 .. 0.76

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 2.2e-07
   3Beta_HSD 110 vlvYtSsaevvgpnslgeeilngdEeleyeslhqdaypesKalaE.klvlkaNgrtlknggrlyTcaLRpagiyGegdkllvpllkq..laklglalfk 205
                  +v+tS +   g+   +e +l  dE+ + e++h+  ++e ++  E +lv   Ng    + + l Tc +Rp  +yG     +++ + +  +++ g +l  
  EFC39071.1 106 LFVFTSGIMTYGN-ASSETFL--DENVRPEPTHS--WTEKRKNFEfELV---NG----EFNYLDTCVIRPGFVYGKSGGGIFTDYFNpkITQDG-KLSI 191
                 5788888877666.7778888..77766665553..4444444441444...66....44479************9877776666541144444.8888 PP

   3Beta_HSD 206 igdeevlsdrvYvgNvawahilAaralqdpkkkssvagqayfisddsPvesyddfnltllkelglel 272
                  g+++   ++v v+ +  a+   ++ +q    ++ v+gq + i + +    yd     + k+ g + 
  EFC39071.1 192 AGSPKKRWSWVHVDDLGEAY---SKVVQVG--RKLVSGQLFNIANPNDYPTYDRVRIEIAKQTGWKP 253
                 999**************997...6666666..889********987777777999999999999875 PP

>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   5.9e-06     0.013       1      37 [.       4      40 ..       4      89 .. 0.81
   2 ?    2.1   0.0     0.052   1.2e+02     143     217 ..     174     241 ..     157     258 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 5.9e-06
                EEESSTTSHHHHHHHHHHHHHT-EEEEEES-S-SHHH CS
        NmrA  1 IlviGaTGrqGksvvrallkaghkvralvRdtksela 37
                +lv+Ga G++G  v +al ++g++v  ++R +k+e++
  EFC39071.1  4 VLVLGANGYIGLGVSQALQRNGFSVHGVIRSEKHEKL 40
                79*****************************988876 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.052
                 EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE.-HHHHHHHHHHHHHHHHHHH.TTEE..EEE-SEEE-HHHH CS
        NmrA 143 ffmenflsllaqlkvgdtappedkvtllgpgnpkavll.daeeDiGafvikilkdprkl.kgkr..iklagntlsgnei 217
                 +f+ +f +++ q        ++   +l+  g+pk +   ++++D G++  k+++  rkl +g+   i+ ++++ +++ +
  EFC39071.1 174 IFTDYFNPKITQ--------DG---KLSIAGSPKKRWSwVHVDDLGEAYSKVVQVGRKLvSGQLfnIANPNDYPTYDRV 241
                 555555554444........33...34445555566656799************9999988886225556666666655 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.0   8.2e-07    0.0018       1     153 [.       8     173 ..       8     191 .. 0.64

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 8.2e-07
                     TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCHHHHCTTTCE.EEE--TT...-CCHHHHHHTT-SEEEES---TCCHHHH....HHHHHHHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRnpeklaeleaeegle.vvegdvt...dvedlaealkgadaVvsalggggkdeeg....aknivdaake 87 
                     GA+G +G  + + l ++ g++v+ ++R++++ + l  +++++ ++   ++   ++e+  + l+ +++++ ++g ++++++      ++ ++ +k 
      EFC39071.1   8 GANGYIGLGVSQALQRN-GFSVHGVIRSEKHEKLLW-QSEITpLIISKAEtlfTEEKFGKILEKTSVIIDCIGLTEETDKFvqllKDHSAERLK- 99 
                     9******9998777666.7************99776.56666144433331125899***************9888755553443444444444. PP

                     CT--EEEEEEETTT..TSGCGCH..HHHHHHHCCHHHHHHHHHHHH.HHHH...SSSEEEEEEE-CEE-ST--S CS
  NAD_binding_10  88 agvkRfvlvsaigv..gdevpge..fgewnkellkaylaakraaee.llra...sgldwTivrpggLtdepttk 153
                     ++  R+++v + g+  + ++ +e  ++e ++    + + +kr+  e +l +     ld  ++rpg+   + +++
      EFC39071.1 100 KKLGRLLFVFTSGImtYGNASSEtfLDENVRPEPTHSWTEKRKNFEfELVNgefNYLDTCVIRPGFVYGKSGGG 173
                     45666666655544115444443113333444555666666664442355535567777888888877666555 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   1.7e-06    0.0039       3      74 ..       4      76 ..       2     118 .. 0.86

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.7e-06
                EEEETTTSHHHHHHHHHHHHSTTEEEEEEEETTC..STTTTTBHHHHSSSS--S-BEBSSHHHHHHH-SEEEE- CS
      DapB_N  3 vavvGasGrmGkevvkaveeaedlelvaavdrke..selegkdagellglgklgvavtddleevlekadvliDF 74
                v+v+Ga+G +G  v +a+++ +++ +++++ +++  + l ++++  l+ ++   +++++++ ++lek+ v+iD 
  EFC39071.1  4 VLVLGANGYIGLGVSQALQR-NGFSVHGVIRSEKheKLLWQSEITPLIISKAETLFTEEKFGKILEKTSVIIDC 76
                89****************99.9********99885233456777777777788888889**************4 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   0.00012      0.27       2      34 ..       3      35 ..       1      75 [. 0.85
   2 ?    0.6   0.0      0.11   2.4e+02     141     175 ..     156     191 ..     108     261 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00012
                   EEEEESTTSHHHHHHHHHCTTTSEEEEEE-TTT CS
  RmlD_sub_bind  2 kilvtGanGqlGseLakqlaeeglevlaltree 34
                   ++lv+GanG +G  + ++l+++g++v+++ r+e
     EFC39071.1  3 TVLVLGANGYIGLGVSQALQRNGFSVHGVIRSE 35
                   59*************************997763 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.11
                    SSEEEEEE-SEESSSSS-.HHHHHHHHHHH-SEEEE CS
  RmlD_sub_bind 141 kkalivRtswvygekgkn.fvktmlrlakereelkv 175
                     +++++R + vyg++g   f   +  + +++ +l++
     EFC39071.1 156 LDTCVIRPGFVYGKSGGGiFTDYFNPKITQDGKLSI 191
                    567899999***997765144444445566666665 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00015      0.34       2      81 ..      13      92 ..      13      95 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00015
                HHHHHHHHHHHTT-EEEEEESSHHHHHHHHHTTESEEEETTTC.H.HHHHHHHHTTTSSEEEEEESSCSHHHHHHHHHCEEE CS
  ADH_zinc_N  2 vGlaavqlAkalGaeviavdsseeklelakklGadevinykea.d.lverikeltggegvdvvfecvGsgatleaalkllkp 81
                +Gl + q++   G+ v++v +se+  +l+ +   + +i +k +    +e+  ++   e+  v+++c+G  +  +  ++llk 
  EFC39071.1 13 IGLGVSQALQRNGFSVHGVIRSEKHEKLLWQSEITPLIISKAEtLfTEEKFGKIL--EKTSVIIDCIGLTEETDKFVQLLKD 92
                7999*****************************9999999554442445555555..6999*******99999999998885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.54
# Mc/sec: 1769.55
//
Query:       EFC39072.1  [L=433]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.6e-05   22.8   0.0    0.00038   20.5   0.0    2.1  2  Lactamase_B     Metallo-beta-lactamase superfamily
  ------ inclusion threshold ------
       0.21   11.7   0.4       0.35   10.9   0.4    1.4  1  YL1             YL1 nuclear protein
        0.6   10.3   4.4        2.1    8.5   0.4    2.6  2  Zn-ribbon_8     Zinc ribbon domain


Domain annotation for each model (and alignments):
>> Lactamase_B  Metallo-beta-lactamase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   6.3e-08   0.00038       6      68 ..     179     238 ..     175     242 .. 0.92
   2 ?   -1.4   0.0      0.33   1.9e+03     140     153 ..     297     310 ..     293     337 .. 0.72

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 6.3e-08
                  SEEEEEEETTCEEEES--SCHHHHHHHHHHHHHTSGGGGEEEEE-SBSSHHHHTTGGGCTTHH CS
  Lactamase_B   6 vnsyliegdggviLiDtGtsteaaraalelaalglkpkdvdavilTHlHlDHiGglgglveat 68 
                  + +++++ ++ ++ iDtG+s  ++ +    ++  +   + +++i+TH+++DH +++++++e++
   EFC39072.1 179 GDCVVVRYKNLTLGIDTGYSKYFTNIP---KQFNFSKSNHSYLIVTHADSDHSAAVDKFIEKA 238
                  67999999999999***********95...7****************************9986 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.33
                  ETTCCEEEECTTTS CS
  Lactamase_B 140 ygggkvlftGDall 153
                   +g+k++f+GD  +
   EFC39072.1 297 WRGKKLVFAGDQQY 310
                  56788888888655 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.4   5.9e-05      0.35      31      54 ..     146     166 ..     116     256 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 5.9e-05
                 xxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1  31 eedDeefeseeeeeeeensDsdfd 54 
                 +edDe++ ++ee+e++   D  fd
  EFC39072.1 146 DEDDEDYDEDEEDEDD---DTTFD 166
                 9*******99988885...65555 PP

>> Zn-ribbon_8  Zinc ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.4   0.00035       2.1       5      33 ..      36      66 ..      33      69 .. 0.80
   2 ?    2.5   0.3     0.027   1.6e+02       5      18 ..      93     111 ..      91     116 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00035
  Zn-ribbon_8  5 eYrCeeCghefe.vlqsisdaplta.CPeCg 33
                 +Y+ ++Cg+ +e  +  i +      CP+C 
   EFC39072.1 36 DYESDSCGEIYEtNFKDIEEITVSSiCPRCR 66
                 69999*******66666667777778****7 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.027
  Zn-ribbon_8   5 eYr.....CeeCghefevl 18 
                  eY      C++C++e e+ 
   EFC39072.1  93 EYDvgggcCDSCNSEVEPE 111
                  5555566699999999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (433 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       710  (0.0396006); expected 358.6 (0.02)
Passed bias filter:                      435  (0.0242624); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2447.21
//
Query:       EFC39073.1  [L=274]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    6.2e-21   75.1   0.0    7.6e-21   74.8   0.0    1.0  1  SGL        SMP-30/Gluconolactonase/LRE-like region
    1.9e-14   52.8   1.3    0.00083   19.3   0.0    5.5  6  NHL        NHL repeat
    0.00085   19.3   0.6     0.0086   16.1   0.0    2.9  3  SBBP       Beta-propeller repeat
     0.0031   17.6   0.1      0.099   12.8   0.0    3.2  3  Str_synth  Strictosidine synthase


Domain annotation for each model (and alignments):
>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.8   0.0   1.7e-24   7.6e-21       5     243 ..      15     263 ..      13     266 .. 0.84

  Alignments for each domain:
  == domain 1  score: 74.8 bits;  conditional E-value: 1.7e-24
         SGL   5 pvwdeeegaLlwvDilgqrihrldpatgketvldtpe....svGaiaprkdgrlvvasksglall..dlasgeletlade.eedekpllrfNDgvvdpd 96 
                 p+ d  +g L ++ i ++ ++ + + +++++++++ +    + G+++++ dg ++va + + a+l  ++++ +  ++++  + ++ p + +N + vd++
  EFC39073.1  15 PIFD-TQGGLCFSSINTGDVYLVPQGGESDQTIHLTNtkgsPTGVAFNYVDGSILVADSANQAILkvNPENNNQVQIIRGdFRGK-PFIGPNNVIVDSK 111
                 6666.4889**************999999999888877889************************88565555555555526566.************* PP

         SGL  97 GrlwfGtmgdeeakgeev..galyrldpdgk.l.ervlddltipNGlawspd.gktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGla 190
                 G ++f + g   +++ e+  g++y l++dgk l ++  + l+ p Gla+sp  ++ +Y+a++++++i ++             vf +l+ g g p G++
  EFC39073.1 112 GMMYFSDSGPLGETSIENpkGSVYCLSTDGKiLkSLAYECLAYPSGLAFSPHsEDVIYVAETMKNRILRFTHINGA---FYCSVFQQLSGGFG-PTGIC 206
                 ********999999998899*********773414455889*********972567899***********994333...45678989988876.***** PP

         SGL 191 vDaeGnvwvAvw......gggkvvrfdpdGklieeiklp.akrvtscaFgGpdlrtLyit 243
                 vD eGn++vA++       +g++ +++++G l +ei l   + +t +++   ++  Lyit
  EFC39073.1 207 VDDEGNIYVAMYefkqvsTEGRILVLSEAGVLKKEIILEnISEITGITY---KRGFLYIT 263
                 ************999998889*****************96667777776...88999998 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0         4   1.8e+04      11      16 ..      29      34 ..      27      35 .. 0.75
   2 !   19.3   0.0   1.9e-07   0.00083       3      26 ..      54      78 ..      53      80 .. 0.92
   3 ?   -1.0   0.1      0.49   2.2e+03      21      27 ..      84      90 ..      83      91 .. 0.85
   4 !    7.7   0.0   0.00085       3.8       1      28 []     152     181 ..     152     181 .. 0.91
   5 !   18.5   0.0   3.3e-07    0.0015       4      21 ..     202     219 ..     201     225 .. 0.91
   6 ?    0.4   0.0      0.18   7.9e+02       5      21 ..     251     266 ..     248     267 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 4
                TTTEEE CS
         NHL 11 snGdiy 16
                ++Gd+y
  EFC39073.1 29 NTGDVY 34
                689998 PP

  == domain 2  score: 19.3 bits;  conditional E-value: 1.9e-07
                SEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL  3 yPhGvavd.snGdiyVaDsenhrvq 26
                +P+Gva +  +G i+VaDs n+ + 
  EFC39073.1 54 SPTGVAFNyVDGSILVADSANQAIL 78
                6********************9886 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.49
                CCTEEEE CS
         NHL 21 enhrvqv 27
                +n++vq+
  EFC39073.1 84 NNNQVQI 90
                8****98 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.00085
                 BSSEEEEEEE..TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd..snGdiyVaDsenhrvqvF 28 
                 ++yP+G+a +  s + iyVa++  +r+  F
  EFC39073.1 152 LAYPSGLAFSphSEDVIYVAETMKNRILRF 181
                 689*******9999*******999999887 PP

  == domain 5  score: 18.5 bits;  conditional E-value: 3.3e-07
                 EEEEEEETTTEEEEEECC CS
         NHL   4 PhGvavdsnGdiyVaDse 21 
                 P+G++vd+ G+iyVa +e
  EFC39073.1 202 PTGICVDDEGNIYVAMYE 219
                 9**************986 PP

  == domain 6  score: 0.4 bits;  conditional E-value: 0.18
                 EEEEEETTTEEEEEECC CS
         NHL   5 hGvavdsnGdiyVaDse 21 
                 +G+++ + G +y+++ +
  EFC39073.1 251 TGITY-KRGFLYITEGN 266
                 79999.9******9865 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.43   1.9e+03      15      24 ..     103     112 ..     102     112 .. 0.90
   2 !   16.1   0.0   1.9e-06    0.0086       5      29 ..     195     216 ..     193     216 .. 0.81
   3 ?   -3.0   0.0       1.7   7.7e+03      24      29 ..     258     263 ..     256     263 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.43
        SBBP  15 gngIavDsnG 24 
                 +n++ vDs G
  EFC39073.1 103 PNNVIVDSKG 112
                 799****988 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 1.9e-06
        SBBP   5 qlGgpgastygngIavDsnGNiYvt 29 
                 ql g+     ++gI vD++GNiYv+
  EFC39073.1 195 QLSGGFG---PTGICVDDEGNIYVA 216
                 5666666...99************7 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 1.7
        SBBP  24 GNiYvt 29 
                 G+ Y+t
  EFC39073.1 258 GFLYIT 263
                 99**98 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0   2.2e-05     0.099       6      84 ..     109     181 ..     104     186 .. 0.76
   2 ?   -1.4   0.0      0.58   2.6e+03      27      45 ..     217     235 ..     207     260 .. 0.59
   3 ?   -1.7   0.0      0.75   3.3e+03       8      22 ..     256     270 ..     252     272 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.2e-05
   Str_synth   6 deetgvlyftdsSskydrrqvllallegdktGrllkydkstkvvkvll.dkLyfanGialsedgsfvl.vcetamkrisry 84 
                 d++ g++yf+ds         l +   ++++G ++ +    k  k l+ + L+++ G+a s+  + v+ v+et ++ri r+
  EFC39073.1 109 DSK-GMMYFSDSGP-------LGETSIENPKGSVYCLSTDGKILKSLAyECLAYPSGLAFSPHSEDVIyVAETMKNRILRF 181
                 444.6666666543.......455566789999999999999999997467***********9888873679999999986 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.58
   Str_synth  27 llallegdktGrllkydks 45 
                 ++++ +   +Gr+l + + 
  EFC39073.1 217 MYEFKQVSTEGRILVLSEA 235
                 4555556666777666554 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.75
   Str_synth   8 etgvlyftdsSskyd 22 
                 + g ly+t+  s+y+
  EFC39073.1 256 KRGFLYITEGNSVYK 270
                 56999***9999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       310  (0.0172904); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.34s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1578.89
//
Query:       EFC39074.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       757  (0.0422221); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.68u 0.28s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 3406.41
//
Query:       EFC39075.1  [L=1016]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
   8.5e-154  514.1   0.0   1.1e-153  513.8   0.0    1.0  1  Penicil_amidase  Penicillin amidase
     0.0019   18.2   1.3     0.0044   17.1   0.1    2.1  2  DUF1634          Protein of unknown function (DUF1634)
  ------ inclusion threshold ------
      0.047   13.8   0.1       0.71   10.0   0.0    2.6  2  PFO_beta_C       Pyruvate ferredoxin oxidoreductase beta subu
       0.15   12.0   2.5       0.27   11.1   0.1    2.3  2  DUF2721          Protein of unknown function (DUF2721)
       0.41   10.8   5.1       0.16   12.1   1.6    2.0  2  GWT1             GWT1
        0.6   10.4  10.5       0.41   11.0   0.5    2.9  3  Orf78            Orf78 (ac78)
        1.8    7.2   9.7          3    6.5   5.4    2.7  3  DUF2207          Predicted membrane protein (DUF2207)
        4.8    7.0   6.2        4.4    7.2   0.1    3.4  3  Synaptobrevin    Synaptobrevin


Domain annotation for each model (and alignments):
>> Penicil_amidase  Penicillin amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  513.8   0.0  4.8e-157  1.1e-153       9     672 ..     231    1004 ..     225    1006 .. 0.90

  Alignments for each domain:
  == domain 1  score: 513.8 bits;  conditional E-value: 4.8e-157
                       GGEEEEE-SSHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHH-TBHHHHHHHHHHHT-HHHHHHHHHTS.....HHHHHHHHHHHHHHH CS
  Penicil_amidase    9 wgvphIyAkneedlffaqGyvhAqdrlwqmellrrtarGrlaelfGpealesDrllrtlglrraaeaelaalldpetralleaYaaGvNayl 100 
                        gv hI+Ak++++lffaqG v+A++rl+qme++rr++rG+l++l+G++ale D++ rtlgl r+ ++ l++l d +++  l+a+ +GvN yl
       EFC39075.1  231 SGVFHIHAKTDYELFFAQGVVTAKERLFQMEIMRRMGRGTLSALIGEDALELDKWSRTLGLLRNSKNHLQDL-DYRANLTLTAFFDGVNSYL 321 
                       79*******************************************************************666.5678*************** PP

                       HH-..-ST-HH.HHHH---......S.........SS-.XXXXXX.....XXX.XXXXXXXX.............................. CS
  Penicil_amidase  101 aelkakalPlefallgykpe..pWtpvdslavakvmaldlagnleeelararalaaklgdekvaelfpp....................... 167 
                       +++++  +P+e+ l+  k +  ++++vd+l++ k+ ald ++n+  e  r + l+++ + +++ e++p+                       
       EFC39075.1  322 KTNPK--MPPEYWLIFNKKTihKFEVVDALVFWKLAALDISTNIFMEKVRFNSLRKNNTLAHTMEFYPTyprswpeqfkktdlniqatqeei 411 
                       99885..9*******98884449*****************889999999988899999999999999955577889999999********** PP

                       ..............................................................................X-EEEEE-TTTBTT CS
  Penicil_amidase  168 ..............................................................................gSNnwvvsgerTas 181 
                                                                                                     +SN+w+v+g++T++
       EFC39075.1  412 daleerftnnfgafmpkneqsdndnnndgdgdivpedpedpivqegftrklrkikknhpavynsiesffnkkshesyfASNAWAVHGSKTKN 503 
                       ***********************************************99999999999999999999999999999999************* PP

                       SS-EEEEE-EEESSGGG--EEEEEEETT..EEEEEEE-TT-S.SSEEEESSEEEEEEE-SS-SEEEEEE.EEETTEEEEEEETTEEEE-EEE CS
  Penicil_amidase  182 GkpllanDPHlglsapslwyqahlqapg..ldviGaslpGlPgvliGhnediAWglTnagadvqdlyae.klnpddptrylydgkwepmetr 270 
                       Gkp+lanDPH++l+ap  +++ hl +++  ld iGa+ p +Pg++iG+n++ +W++T++g+dvqdl+++ +++   + +y+++g+++++ t+
       EFC39075.1  504 GKPILANDPHMKLTAPLPFIMFHLVSEEsgLDTIGATYPLIPGIVIGRNKNSSWAITSSGSDVQDLFVLdQIS---DSTYVVNGTEHDYVTH 592 
                       **************************9666*************************************994444...368************* PP

                       EEEEEEE-TT.EEEEEEEEETTEEEE-............TB--EEEEG-TTHHHHHHHHHT--SHHHHHHHHHHH---SEEEEEEETT--EE CS
  Penicil_amidase  271 tetikvkggddsvtltvreTrhGPvvsd.......gkavalrwtalepgdrsldallalnrarnvaefraalkdlaapaqnvvyADreGnig 355 
                       +e+i+  + ++ vt+ v+ + +GPvv++       ++ val+wt+ +++d+sl+a+++++  +n+ +f++ +++l +p++n +y+D+e ni 
       EFC39075.1  593 QEEIHFDNTQS-VTIHVKDSIYGPVVNTllgwediQEVVALSWTGIKDNDTSLNAVIGIMYQNNWPQFHENMRHLVSPPMNYIYTDAE-NIC 682 
                       ******99887.99**************9987765444**************************************************.*** PP

                       EE--S--B---....TT--EEETT-GGGS--TB--GGGS-EEEE..SSEEEESSS----S.........--T-HHHHHHHHHH..SS...-B CS
  Penicil_amidase  356 yqaagrvPvrp.aaddgllpvpGsdsayeWtgyipfeelPqvvnPargyivtaNnrvlpddypaalgsdwappyRarrirelLeekaagkkv 446 
                         +ag vP+r+ ++ +gl+pv G+ ++++++gy+p+e++P+v nP+r ++v aN r+ p++yp++lg d++ +yR +ri++lL   +++k++
       EFC39075.1  683 SLVAGMVPIRKyGH-TGLFPVSGN-GTFDYEGYVPYEKMPYVCNPERKFVVAANARIEPPGYPYYLGADVGTKYRLERIEDLL---SSNKTF 769 
                       ***********544.6*******9.77********************************************************...77789* PP

                       -HHHHHHHHHT-BBTHHHHHHHHH..........-..GGGHHHHHHHHH-.SB-STT-THHHHHHHHHHHHTT................... CS
  Penicil_amidase  447 tledmaalqtdtrsllaerllpll.al......eaaeaeaaaaldlLraWdgrmdadsaaaalfaawlaalvralfedelg...rlaealek 528 
                       ++ +m ++q+dt+s l  +l p + +l           +++  ++ L++Wdg +  +s++a+lf+ + ++l++  + ++lg   ++   +++
       EFC39075.1  770 NITNMVDIQLDTYSKLFFDLKPFIsKLkntsltF----QEEVIRKDLEKWDGYLILGSKQASLFEMFHTKLWNMSY-ADLGvenSNIIYIKN 856 
                       **********************999444433321....223389*****************************886.557777733334455 PP

                       .....---TTSTTT-SE..SHH.HHHHHHHHHHHHHHHST-T-B.....HH.HHEEEE.E................EE---B-GGG...... CS
  Penicil_amidase  529 lledasfwwddptttpk..trdelllaalaealaeleaaglgadpakwrwg.klhrlelrhplg........fnrglpvgGgeetvnatsys 609 
                        l+++      +++++   t+ + +++a+++ +a+l+  + ++++ +  wg  +h ++  hp++         + +  v+Gg++t+n ++  
       EFC39075.1  857 ALNKT-----GRCSPNLpkTCMSYAVSAFKQSIADLKVLSKSTEIPS--WGvGIHSTTYFHPVFhsyafscaCDKRHYVPGGTDTINFSRVT 941 
                       55533.....22222224489***************99865555555..555688889999*9999998887544577*********99998 PP

                       ...EEEEEEE-EEEEEE--T.S.EEEEETT-S-S-TTSTTSSHHHHHHHTT--EEE--SHHHH CS
  Penicil_amidase  610 arafrvtrgpsyrmvvdladrdkaravlpgGqsgnpgsphyaDqlelwaegeylplpfteaai 672 
                        ++ + ++g ++r++ +++d d   +++p Gqs n  +  y+  l+ +aeg+y++l+ ++ ++
       EFC39075.1  942 ETNLDSSHGVAFRQITSMSDADGDLFITPLGQSANWLDYDYHSNLQIFAEGRYHSLKRKNYKV 1004
                       8889***************************************************99887766 PP

>> DUF1634  Protein of unknown function (DUF1634)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.1     2e-06    0.0044      28      90 ..      52     114 ..      38     133 .. 0.83
   2 ?   -1.2   0.3      0.98   2.2e+03      51      65 ..     178     192 ..     120     205 .. 0.42

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 2e-06
     DUF1634  28 gssesenseltslseilegllelkglaiiqlGllvLiatPvlrVvlsliaFlkekdilyviit 90 
                 +++e++++e t++++  +++   + + +i++  ++L a+ +l +++s + F+++   l+v  +
  EFC39075.1  52 KEEEENKEENTDPKKKKKKIRWYHTKCFIYFAAIILAAISILTIIISYVLFVRHNHLLFVCNS 114
                 224477888999999999****************************************99755 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.98
     DUF1634  51 kglaiiqlGllvLia 65 
                    ++ +l ++ Li 
  EFC39075.1 178 VVISLCLLTIFTLIY 192
                 222222333333333 PP

>> PFO_beta_C  Pyruvate ferredoxin oxidoreductase beta subunit C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1      0.36   8.1e+02      10      24 ..     139     153 ..     135     169 .. 0.82
   2 ?   10.0   0.0   0.00032      0.71      43      64 ..     645     666 ..     623     668 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.36
                 SXXXXX-EEEGGGST CS
  PFO_beta_C  10 fdwYkervykleedg 24 
                  +wYk++  ++ e++
  EFC39075.1 139 NEWYKQHHSEVAESD 153
                 58******9999963 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00032
                 -EEEEEEEETTS--HHHHHHT. CS
  PFO_beta_C  43 kiplGifYkeekptyeerleel 64 
                 + ++Gi+Y+++ p ++e++++l
  EFC39075.1 645 NAVIGIMYQNNWPQFHENMRHL 666
                 578***************9986 PP

>> DUF2721  Protein of unknown function (DUF2721)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1   0.00012      0.27      33     116 ..      52     136 ..      39     147 .. 0.58
   2 ?    0.0   0.3      0.33   7.3e+02      48      86 ..     155     192 ..     134     209 .. 0.51

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00012
     DUF2721  33 edeleelaeeeeedeelakeiknlrrRarlirrailllvlsallvvlvvlllfl.sall.sldlsllaailfvlalllllvslllf 116
                 ++e e+++e++ + ++ +k+i+  +  + +  +ai+l+++s+l+++++ +l +  ++ll   + + ++++ f+  ++l++++++ f
  EFC39075.1  52 KEEEENKEENT-DPKKKKKKIRWYHTKCFIYFAAIILAAISILTIIISYVLFVRhNHLLfVCNSAEFIVVSFFEVIILICAAIVAF 136
                 22222222222.23555556888888888888888888888877776654444344444466666667777666666666666555 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.33
     DUF2721  48 elakeiknlrrRarlirrailllvlsallvvlvvlllfl 86 
                 +l+ + +    R +li + + + v+ + l++l++++l+ 
  EFC39075.1 155 DLKLKYSDNLARDKLIMKFQNTSVV-ISLCLLTIFTLIY 192
                 4444444444566666666655544.2333333333333 PP

>> GWT1  GWT1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   1.6   7.2e-05      0.16      17     118 ..      36     152 ..      33     173 .. 0.54
   2 ?   -1.0   0.1      0.77   1.7e+03      48      70 ..     173     195 ..     136     218 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 7.2e-05
        GWT1  17 llgvslgkyvlkrekeaeeee.........kkkkkkkkesketlkllikllllsilllllllllelyvef.......vSRrlaNlpYvlwvvalnltll 99 
                 l  vs++++++k ++e+eeee         k      k++k  ++ ++ ++++++++l+++ +l++ +++           ++N + +++v  + +++l
  EFC39075.1  36 LTPVSINQLLHKAQQEKEEEEnkeentdpkK------KKKKIRWYHTKCFIYFAAIILAAISILTIIISYvlfvrhnHLLFVCNSAEFIVVSFFEVIIL 128
                 5668889999987777774445543332221......22222233333333333444444455555555534333333567899999899999999999 PP

        GWT1 100 llflliel.lfv....ekeeeker 118
                 ++  ++ + l      +++e +e+
  EFC39075.1 129 ICAAIVAFkLNEwykqHHSEVAES 152
                 988888873332554433333333 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.77
        GWT1  48 ketlkllikllllsillllllll 70 
                  + ++++i+l+ll+i++l+ l l
  EFC39075.1 173 FQNTSVVISLCLLTIFTLIYLAL 195
                 34444444554444444433222 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.5   0.00018      0.41      34      93 ..      48     107 ..      38     118 .. 0.66
   2 ?   -2.4   0.1       2.6   5.9e+03      68      82 ..     117     131 ..     111     148 .. 0.72
   3 ?    4.8   1.4     0.016        35      54      86 ..     168     201 ..     132     214 .. 0.44

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00018
       Orf78  34 aenkkekksaaeknditekesnaaekaqalnillisllavvcvlvllyviyYfvilrerq 93 
                 a+++ke+++++e+n   +k++++ +  +++  + ++++ + ++ +l ++i+Y + +r+++
  EFC39075.1  48 AQQEKEEEENKEENTDPKKKKKKIRWYHTKCFIYFAAIILAAISILTIIISYVLFVRHNH 107
                 233333333333333333333346677788889999999999999999****99999875 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.6
       Orf78  68 isllavvcvlvllyv 82 
                 + +++++ v++l+ +
  EFC39075.1 117 FIVVSFFEVIILICA 131
                 567888888888754 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.016
       Orf78  54 snaaekaqalnillisllavvcvlvl.lyviyYf 86 
                 +  ++ +++  ++ + ll++++++ l l+vi+ +
  EFC39075.1 168 KLIMKFQNTSVVISLCLLTIFTLIYLaLFVILLY 201
                 1123333333444444444444433224444444 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   5.4    0.0014         3     361     409 ..      49     136 ..      14     221 .. 0.55
   2 ?    2.2   0.7     0.026        59     190     238 ..     150     205 ..     121     324 .. 0.72
   3 ?   -2.2   0.1      0.56   1.3e+03     349     388 ..     454     496 ..     396     498 .. 0.66

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0014
     DUF2207 361 ksavkk..kergyfdkkgkkklkklsalglgliilglilillallllvll.....................................l 409
                 +++ ++  ++++  d k+kkk+ ++     ++ ++++il+ +++l++++                                      +
  EFC39075.1  49 QQEKEEeeNKEENTDPKKKKKKIRWYHTKCFIYFAAIILAAISILTIIISyvlfvrhnhllfvcnsaefivvsffeviilicaaivaF 136
                 3333333433334444443333333333333333333333222222222255567777777787655433333333333333333330 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.026
     DUF2207 190 lkeeqk.......ntreraarlslallillilllilllllllllliklllwkkygr 238
                  +++++       n  +++   ++  + ++i l++l ++ l++l+++++l++   +
  EFC39075.1 150 AESDEDlklkysdNLARDKLIMKFQNTSVVISLCLLTIFTLIYLALFVILLYGISK 205
                 33333344545555556666666666666666666666666666666555554333 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.56
     DUF2207 349 kakkfkkalkkwksavkk...kergyfdkkgkkklkklsalgl 388
                  ++ f ++l+k+k++  +   + + +f+kk+ + ++ ++a+++
  EFC39075.1 454 VQEGFTRKLRKIKKNHPAvynSIESFFNKKSHESYFASNAWAV 496
                 4455666666666654446667888999999999999999886 PP

>> Synaptobrevin  Synaptobrevin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.1    0.0019       4.4      55      87 ..      65      97 ..      40     100 .. 0.81
   2 ?   -0.4   0.4      0.46     1e+03      60      86 ..     170     196 ..     159     199 .. 0.56
   3 ?    0.1   0.1      0.32   7.1e+02       4      32 ..     403     431 ..     400     435 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0019
                   HHHHHHHHHHTXXXXXXXXXXXXXXXXXXXXXX CS
  Synaptobrevin 55 rklkrkmwwknmkliiililvvlililiiiivi 87
                   +k k+k  w + k+ i++++++l+ i i+ i+i
     EFC39075.1 65 KKKKKKIRWYHTKCFIYFAAIILAAISILTIII 97
                   56789999*************999999888776 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.46
                    HHHHHTXXXXXXXXXXXXXXXXXXXXX CS
  Synaptobrevin  60 kmwwknmkliiililvvlililiiiiv 86 
                     m ++n  ++i l+l+ ++ ++++ ++
     EFC39075.1 170 IMKFQNTSVVISLCLLTIFTLIYLALF 196
                    355666666666666655555555544 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.32
                    HHHHHHHHHHCCCCHHCCHHHHCHCCCCC CS
  Synaptobrevin   4 klakikaevdevkdimkeNidkvlergek 32 
                    +++++++e+d  ++  ++N+  ++ ++e+
     EFC39075.1 403 NIQATQEEIDALEERFTNNFGAFMPKNEQ 431
                    7899***************9988877766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1016 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1805  (0.100675); expected 358.6 (0.02)
Passed bias filter:                      911  (0.0508115); expected 358.6 (0.02)
Passed Vit filter:                       100  (0.00557756); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.97u 0.34s 00:00:01.31 Elapsed: 00:00:00.52
# Mc/sec: 5862.99
//
Query:       EFC39076.1  [L=661]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   1.6e-148  495.7   1.2     2e-148  495.3   1.2    1.1  1  DUF2828   Domain of unknown function (DUF2828)
  ------ inclusion threshold ------
      0.071   12.5   0.0       0.12   11.7   0.0    1.3  1  VWA_CoxE  VWA domain containing CoxE-like protein


Domain annotation for each model (and alignments):
>> DUF2828  Domain of unknown function (DUF2828)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  495.3   1.2  2.2e-152    2e-148       1     598 [.      61     643 ..      61     655 .. 0.83

  Alignments for each domain:
  == domain 1  score: 495.3 bits;  conditional E-value: 2.2e-152
     DUF2828   1 TenasvayastgsplldlFfeleeetsaeelkelleaaWaedplltLklifnlRsihlGksdregfyraalWLaenHPrTllaNlkalvrpviekkakk 99 
                 Ten++++++s+gs+l+d+F+  +e +s++++++ll+a+W+e+pl tLk+if +R i++Gk++ e fy++  WLa nHP+T+l Nlk +           
  EFC39076.1  61 TENGATTFSSSGSNLVDFFYFTVEGISQQKIHKLLDASWREQPLKTLKVIFFIRDIRNGKGENEIFYETQRWLALNHPQTFLENLKNVP---------- 149
                 9***************************************************************************************9.......... PP

     DUF2828 100 kdvkegvshGywKDllnilalavegel.vlkdpkkvlnvkkekkkeekkkkkkkkkkekkkerk............keekekkeeekeeakekrkekea 185
                        + GywKDl n+l  +  g    +++p+   +++   k+  ++k+  +k+  +k++ +            +e+   ++++++ + ++  ++e 
  EFC39076.1 150 -------TSGYWKDLQNVLLYIRYGGHeRDERPNWAKEKNVLLKRLPSEKSLYEKAIFQKRR-SyrpikteedrriREKDIANQVKQSFSPNELWNQEV 240
                 .......78********988776655534444443333332222222222222221111111.123444444444322222222222222223336666 PP

     DUF2828 186 eraeklleklesdkkyraLhlt....varlFaeqLkkDlellesakkkakkkisLaaKWaPslesshDkhtllaeaiaellfpre....lssel..... 271
                 ++ ekl+ + e+ kk ++++ +    v +l+ +qL kD e l++++ k   +++L+aKWaP+++ s D++  + + ia++lfp +    +         
  EFC39076.1 241 RNTEKLVLTKEESKKLKLVYEKakdiVVDLYVDQLLKDRENLSKGEVK---SLTLCAKWAPTINLSTDRQLGIGKQIAQKLFPFDqpdgI---Qltirk 333
                 7778888888888889999864333399***************66555...5*******************************9955552...044466 PP

     DUF2828 272 .....keelsreeylkrvreryrkevlspLrkalevvevdisakkweeikYervpSvamkrykelFlkkDeerfekYledVesGkakisgaallPhelv 365
                      k+ ++++ y + +  +y+k +l+ Lrka   +e+ +s+k+w++i+YervpSv+m++ k+lF  kD+erf ++le+V++G++ki ga+l Ph+l+
  EFC39076.1 334 egkgdKKYTDQQVYRYLANIKYQK-LLRDLRKATVTIETFMSSKEWSNIPYERVPSVCMNKKKKLFSLKDNERFVSFLESVKKGEKKINGAVLFPHQLI 431
                 667755566667777777777776.67************************************************************************ PP

     DUF2828 366 keaaklkkkekkeelakkleeaeakvaelQWktlvqrlkesGk..LenciAvcdvSgsmsslsfkkkttpmevaiaLsLlvaelskpPfkgkvitFsee 462
                 ++            +a++ +++ ++++elQW+++v+++ke++   + nci vcdvSgsm   +    +tp++v++aL+Ll++e+    f++k+itFse+
  EFC39076.1 432 EQ-----------LYASH-SKEVSDTIELQWREIVKNVKEKSDngIFNCIPVCDVSGSM---N----GTPLNVCVALGLLMSEINTGIFRNKIITFSEN 511
                 **...........23333.4444689*************99754489************...5....99****************************** PP

     DUF2828 463 pelvkiegektLaekvekveeaewgmntdfqaVFedliLplAvenklkkedmvkrvfvfSDMeFdeaseesekwetsyeaikkkfkeaGYevPeivfWn 561
                 p++v ++g ++++e+ +++ +a+wgm+t++   F +liL++A++n+l+k++m+k+v vfSDM+F+e+s+     +ts++ i + f+e+GYe P i++Wn
  EFC39076.1 512 PSFVDLSGIEGVKERFDNLCKADWGMSTNYISTF-KLILEMALKNNLPKDQMIKKVVVFSDMQFNESSA----DTTSHQEIVDMFAEHGYEAPGIIYWN 605
                 **********************************.*******************************983....379*********************** PP

     DUF2828 562 LadskasvpvtadekgvalvsGfSknllkvFLe.dgev 598
                 L+++ +++p+t ++++va++sGf + llk+ ++ d ++
  EFC39076.1 606 LRGDVDNIPITVTTDNVACMSGFNAILLKMLMDmDLSI 643
                 ********************************966555 PP

>> VWA_CoxE  VWA domain containing CoxE-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   1.4e-05      0.12      61     173 ..     469     587 ..     442     594 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.4e-05
    VWA_CoxE  61 vllvDvSgSmaaysaiflallhAllqqlprtevfaFdtrlvdlTra...lrerDpaeaLarv.saavedlgGgTrigaalaeflelvtrpaLsrrav.. 153
                 + ++DvSgSm+      l ++ Al   ++++++  F  +++  +++   ++ +  + + +r  +    d+g  T++ ++++ +le+  ++ L ++ +  
  EFC39076.1 469 IPVCDVSGSMNG---TPLNVCVALGLLMSEINTGIFRNKIITFSENpsfVDLSGIEGVKERFdNLCKADWGMSTNYISTFKLILEMALKNNLPKDQMik 564
                 669*********...667777778778888888888888888777522223223333333332222456************999999999998887644 PP

    VWA_CoxE 154 .vvlvsD..glergdreellael 173
                  vv++sD  + e+ +   + +e+
  EFC39076.1 565 kVVVFSDmqFNESSADTTSHQEI 587
                 47999996655555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (661 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       965  (0.0538234); expected 358.6 (0.02)
Passed bias filter:                      519  (0.0289475); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 4116.49
//
Query:       EFC39077.1  [L=655]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (655 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       867  (0.0483574); expected 358.6 (0.02)
Passed bias filter:                      585  (0.0326287); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3925.98
//
Query:       EFC39078.1  [L=270]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-11   45.0   0.2    1.4e-11   44.7   0.2    1.1  1  ATG27          Autophagy-related protein 27
    1.5e-05   24.2   4.3    3.5e-05   23.0   4.3    1.5  1  Man-6-P_recep  Mannose-6-phosphate receptor
    0.00065   19.8   2.8        0.6   10.2   0.4    2.2  2  CIMR           Cation-independent mannose-6-phosphate recepto
     0.0094   15.8   0.7     0.0094   15.8   0.7    1.5  2  DUF4013        Protein of unknown function (DUF4013)


Domain annotation for each model (and alignments):
>> ATG27  Autophagy-related protein 27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.7   0.2   3.2e-15   1.4e-11      22     222 ..      24     216 ..       6     255 .. 0.69

  Alignments for each domain:
  == domain 1  score: 44.7 bits;  conditional E-value: 3.2e-15
       ATG27  22 vdkglkkydlsklkgphsvstseetp........psktnttytldiCeplkkkkdvkkedqCpkgtrvCgitrvikkdekde.itqvipiggksldpkv 111
                 ++ g++++ ++ l+  +++   + t+        ++ tn+ ++++iC++        + + C +g+   g+  ++++  ++e   + ++ +++++++++
  EFC39078.1  24 AA-GSQAFCIHTLSDGRTIDLNRATKssadyflyDKDTNYYFYMNICKD--------ALKSC-DGQSYGGVAYTKDPGAESEfCATYMSGSTSEQNYQI 112
                 44.44444444444444444443333000000004557999******64........34569.788889999999996666645555555899999*** PP

       ATG27 112 trlkesdekeglrlelkgg.kygkkkqkaiieflCdekslkfksydeee.eeekdvlrlewktkyACekaekdkkdsskkkeksgwGfFtwlfiilfla 208
                 + +++++++ g+ l ++gg k  +++q+++i++ C  ks+   ++ +e+  ++  v ++++ t++AC  +++++         +g+G++   ++++++ 
  EFC39078.1 113 SLINSQKPELGVVLVVRGGeKVLTRTQQMKITMNC-AKSVGDLKFVQENfVDSNIVFEFSLDTPAACIVTDDNNL--------GGLGYLGLALLLIIII 202
                 ***999999********8736699***********.77776666666666556679************7533333........6899999999999999 PP

       ATG27 209 taaYlifgswlNyn 222
                 +++Y+++g ++N  
  EFC39078.1 203 MILYFAIGYIVNCL 216
                 99999999999864 PP

>> Man-6-P_recep  Mannose-6-phosphate receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   4.3   7.7e-09   3.5e-05      46     220 ..      60     249 ..      42     255 .. 0.65

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 7.7e-09
  Man-6-P_recep  46 dkytyklrvCreveesa...edagliqidkkdkketviGrinetqvldGsdWilliykggdeyeshck........kekrkalimisCnkkvlade 130
                     +y + +++C+++ +s    +  g+  ++    +++    + + +  + +  i+li  +  e              +  ++  i ++C k    ++
     EFC39078.1  60 TNYYFYMNICKDALKSCdgqSYGGVAYTKDPGAESEFCATYMSGSTSEQNYQISLINSQKPELGVVLVvrggekvlTRTQQMKITMNCAK--SVGD 153
                    467777888888877664423345555554445555555555555555555555554444443322212222222134455557778888..5678 PP

  Man-6-P_recep 131 ltlvveerekeedcfylfeldssvaCpkeesk.ls.vG..sillivllslvavyligGflyqrlvvgakG...leqiPnyafWqdlGnlvadGCdf 219
                    l+ v+e+    ++  + f ld  +aC +++++ l  +G   + l++++ ++ +y+ +G++ + l ++  G     q+P++ +W+ l +l  +GC f
     EFC39078.1 154 LKFVQENFVD-SNIVFEFSLDTPAACIVTDDNnLGgLGylGLALLLIIIIMILYFAIGYIVNCLALNKEGgwsYTQLPQFKYWKLLFQLAWEGCLF 248
                    9999888765.566778*********998764232233222334444556779*************988755579*******************99 PP

  Man-6-P_recep 220 v 220
                    +
     EFC39078.1 249 I 249
                    7 PP

>> CIMR  Cation-independent mannose-6-phosphate receptor repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.4   0.00013       0.6      51     102 ..      31      77 ..      21     119 .. 0.75
   2 !    9.9   0.1   0.00017      0.75       4      48 ..     139     183 ..     136     187 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00013
        CIMR  51 CqvtdaagkeyDLsaLsrksenweavdtsasgkkkhfyinvCkpeakiegCp 102
                 C  t + g+++DL   +++s  +   d+ ++     fy+n+Ck+    + C+
  EFC39078.1  31 CIHTLSDGRTIDLNRATKSSADYFLYDKDTN---YYFYMNICKDA--LKSCD 77 
                 777778899**************99998877...89*******44..44454 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00017
        CIMR   4 ratvirFvCnetaledapvflkedigdcsylFew..etalACveked 48 
                 + + i+  C +++  +  +f +e+  d + +Fe+  +t +AC+ ++d
  EFC39078.1 139 QQMKITMNCAKSV--GDLKFVQENFVDSNIVFEFslDTPAACIVTDD 183
                 5678999*****9..899******999999999844699***96555 PP

>> DUF4013  Protein of unknown function (DUF4013)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.2       2.2     1e+04     106     114 ..      10      18 ..       6      29 .. 0.45
   2 !   15.8   0.7   2.1e-06    0.0094       3      44 ..     195     239 ..     193     250 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.2
     DUF4013 106 llfglllpv 114
                 l++ ll+++
  EFC39078.1  10 LVLNLLSIA 18 
                 113333332 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 2.1e-06
     DUF4013   3 sllliiaivlslvllGYlvrvlr...dtirgddelPefddwgkll 44 
                 +lllii+i ++ ++ GY+v +l    +  +  ++lP+f+ w+ l+
  EFC39078.1 195 ALLLIIIIMILYFAIGYIVNCLAlnkEGGWSYTQLPQFKYWKLLF 239
                 677777777789**********966677777888****9998887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (270 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       694  (0.0387082); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1601.79
//
Query:       EFC39079.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-26   91.8   0.1    6.8e-26   91.2   0.1    1.2  1  Pkinase         Protein kinase domain
    7.7e-18   64.7   0.0    9.1e-18   64.5   0.0    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    1.1e-05   24.5   0.0    1.5e-05   24.0   0.0    1.1  1  Pkinase_fungal  Fungal protein kinase
    0.00067   18.7   0.0     0.0012   17.8   0.0    1.4  2  Haspin_kinase   Haspin like kinase domain
     0.0097   15.9   0.0      0.013   15.5   0.0    1.2  1  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.023   14.1   0.0      0.038   13.3   0.0    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
      0.087   12.4   0.7       0.13   11.8   0.1    1.5  2  Choline_kinase  Choline/ethanolamine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.2   0.1   2.6e-29   6.8e-26      77     221 ..       1     164 [.       1     186 [. 0.72

  Alignments for each domain:
  == domain 1  score: 91.2 bits;  conditional E-value: 2.6e-29
                 EE--TTEBHHHHHH..HHSS--HHHHHHHHHHHHHHHHHHHHT.TEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCS...BCTTTSCGGGS- CS
     Pkinase  77 leyveggeladlle..rkgslseeeakkiakqilegleylHsk.giiHrDlKpeNiLidekge....lKitDFGlakelesssk...ltsfvgtseYlA 165
                 ++y e+g+l+d+    +++  s + +k+i++q+l +l y+ ++ +++HrD+Kp NiL+ + ++    + ++DFG+ak+    s+   l+   gt+ ++A
  EFC39079.1   1 MDYYENGSLHDYFIrkNNKPPSANMIKSIMTQVLDALMYMKQNfNMVHRDIKPGNILVRRIENdsidICLADFGMAKNTPGLSEnssLSRAKGTEGFIA 99 
                 799******9998744445588889****************6626*************9433346889999******9877666666************ PP

                 HHHH...TTSCBSHHHHHHHHHHHHHHHHHS....S-S.TTTSSHHHHHHHHHHT.HHHHHHHCT CS
     Pkinase 166 PEvl...keneyskkvDvWslGvilyelltg....kpp.fsgekgkekvekeldq.lekilkilg 221
                 PE+    +e++ys ++D+++lG +l++l+t+    + p f+ + ++ +++++  +  e+i+k+l+
  EFC39079.1 100 PEIYrpiSEQRYSLASDIFALGATLFKLMTRislnEFPyFQWSLDEPTKRNHSSKlEEMIYKMLK 164
                 ***888899*******************9972222333133333333333333332234444444 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.5   0.0   3.5e-21   9.1e-18      80     209 ..       1     141 [.       1     184 [. 0.82

  Alignments for each domain:
  == domain 1  score: 64.5 bits;  conditional E-value: 3.5e-21
                  EE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS CS
  Pkinase_Tyr  80 teyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWm 172
                  ++y ++G+L+++  +k++++ + + + s+++qv +++ y++++ ++vHrd+   N+L+++    +  + ++DfG+a+++   +e ++ ++ak    ++
   EFC39079.1   1 MDYYENGSLHDYFIRKNNKPPSANMIKSIMTQVLDALMYMKQNfNMVHRDIKPGNILVRRiendSIDICLADFGMAKNTPGLSENSSLSRAKGTEGFI 98 
                  789********9999989999*******************98758*************9766434456678********99999999999******** PP

                  -HHH...HHHSEEEHHHHHHHHHHHHHHHHTT...SSGTTTTS CS
  Pkinase_Tyr 173 apEs...lkekkftsksDvWsfGvllwEiftl...gespypgl 209
                  apE+   ++e++++ +sD+++ G +l+ ++t     e py ++
   EFC39079.1  99 APEIyrpISEQRYSLASDIFALGATLFKLMTRislNEFPYFQW 141
                  ***855567889*****************98511134555554 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   5.7e-09   1.5e-05     308     388 ..      29     105 ..      21     119 .. 0.82

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 5.7e-09
  Pkinase_fungal 308 llealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkg 388
                     +++ + Da+   ++   + +++HrDi  +Nil+    ++++    L+D+ +ak++   s++s+  +  GT  F+a e+ + 
      EFC39079.1  29 IMTQVLDALMYMKQ---NFNMVHRDIKPGNILVR-RIENDSIDICLADFGMAKNTPGLSENSSLSRAKGTEGFIAPEIYRP 105
                     55555566555555...55**************9.66778999**************9999999***********998874 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   4.8e-07    0.0012     204     255 ..      22      77 ..      16      90 .. 0.83
   2 ?   -3.2   0.0       1.2   3.1e+03      83      92 ..     155     164 ..     130     183 .. 0.56

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 4.8e-07
  Haspin_kinase 204 swkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdkn....lnvtlidlklsR 255
                    s + ++si+ q++  L    ++f++ HRd++ +niLv++       + l d+ +++
     EFC39079.1  22 SANMIKSIMTQVLDALMYMKQNFNMVHRDIKPGNILVRRIendsIDICLADFGMAK 77 
                    567799********************************985555567777776665 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.2
  Haspin_kinase  83 ilsqilelck 92 
                    + + i+++ k
     EFC39079.1 155 LEEMIYKMLK 164
                    2222222222 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0     5e-06     0.013     164     202 ..      42      82 ..      20     106 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 5e-06
                 S-EEEE-SS-SGGGEEEC....TTEEEEE---TT-EEEECC CS
         APH 164 lptvllHgDlhpgNllvd..pddgrvtGviDfedaglgppl 202
                 +    +H+D++pgN+lv+  ++d   +++ Df++a+  p l
  EFC39079.1  42 QNFNMVHRDIKPGNILVRriENDSIDICLADFGMAKNTPGL 82 
                 566689*************87777779********988755 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.5e-05     0.038     105     168 ..       9      75 ..       5      82 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.5e-05
         Kdo 105 Ledllakwae..laeelkrallkavgrliaklhr.agvnHadlyaknillqqeeeeeaeiwliDldk 168
                 L d+  + ++  ++ ++ + ++ +v  +   + +  ++ H+d+ + nil++  e++ + i+l D+  
  EFC39079.1   9 LHDYFIRKNNkpPSANMIKSIMTQVLDALMYMKQnFNMVHRDIKPGNILVRRIENDSIDICLADFGM 75 
                 666655544457888888999999988888887526999*************************965 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   5.3e-05      0.13     123     172 ..      22      74 ..       8      81 .. 0.84
   2 ?   -2.5   0.1       1.2   3.1e+03     113     136 ..     149     172 ..     134     184 .. 0.52

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.3e-05
                     THHHHHHHHHTHHHHHHCHGG-EEEE-S--SGGGEEE....-CTTEEEE--GT CS
  Choline_kinase 123 nledlekelekleklleelespvvfcHnDlqegNill...nkeekklvlIDFE 172
                     + + +++ ++++   l +++++ ++ H D+ +gNil+   +++  +++l DF 
      EFC39079.1  22 SANMIKSIMTQVLDALMYMKQNFNMVHRDIKPGNILVrriENDSIDICLADFG 74 
                     556778888888888889******************98888888999999995 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.2
                     HHGGCCHCCCTHHHHHHHHHTHHH CS
  Choline_kinase 113 ekkkkqlklinledlekeleklek 136
                     ++++++l+++ ++ l+  +++ ++
      EFC39079.1 149 RNHSSKLEEMIYKMLKINTSTPHE 172
                     334444444444444443333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1198.42
//
Query:       EFC39080.1  [L=452]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.097   12.7   1.6       0.76    9.8   0.2    2.8  2  SH        Viral small hydrophobic protein
        3.8    6.2  17.8         20    3.8   0.1    3.6  2  DUF2207   Predicted membrane protein (DUF2207)


Domain annotation for each model (and alignments):
>> SH  Viral small hydrophobic protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.1     0.096   8.6e+02      14      34 ..      29      49 ..      25      65 .. 0.75
   2 ?    9.8   0.2   8.4e-05      0.76       9      43 ..     410     444 ..     407     448 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.096
          SH 14 llillsliitlyvwiistity 34
                l++ll  i t++    st t+
  EFC39080.1 29 LFLLLVTIFTIFFINFSTSTF 49
                566778889999888898887 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 8.4e-05
          SH   9 yPtflllillsliitlyvwiistityktavrhaal 43 
                 + + lll ++sl++ l+v ii    y+     aal
  EFC39080.1 410 FDAVLLLFFFSLVLWLFVMIIEFRRYRKETVEAAL 444
                 66789*****************9999988888887 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1    0.0022        20     408     409 ..     150     169 ..      10     234 .. 0.58
   2 ?   -0.6  14.1     0.046   4.1e+02     335     432 ..     243     350 ..     227     444 .. 0.81

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.0022
     DUF2207 408 l..................l 409
                 +                  +
  EFC39080.1 150 FnsvflphirkrirtssisN 169
                 12333333444444433332 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.046
     DUF2207 335 s.lkeikkyakkskkkakkfkkalkkwksavkkkergyfdkkgkkklkklsalglgliilglilillallllvll...............lvfllilll 417
                 s l++  +++ +++ + +k+++++++ +  ++k     +  kg + ++++  l+++++ ++li+i+l +l ++++               +  + i+++
  EFC39080.1 243 SrLSSFHQQIYEDR-EEEKLQSTFQRRTAWIRK-----IVVKGFWVIFSFESLATICFTFSLIAIFLRALNANSAqsgelyrwiqlgamlFQRIPIIII 335
                 24566666666666.666666666666666666.....56669999*******************9999999999********8888766666666666 PP

     DUF2207 418 illliaiivlllfsr 432
                  +l+i+++++ +f++
  EFC39080.1 336 CFLIIMSGFFSIFKK 350
                 666666666666544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (452 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       889  (0.0495845); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.29s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 2738.90
//
Query:       EFC39081.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.032   14.0   0.6        0.3   10.9   0.0    2.6  2  SRA1      Steroid receptor RNA activator (SRA1)


Domain annotation for each model (and alignments):
>> SRA1  Steroid receptor RNA activator (SRA1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   1.7e-05       0.3       5     119 ..      70     194 ..      61     204 .. 0.64
   2 ?   -2.6   0.1      0.24   4.2e+03      10      29 ..     428     447 ..     422     458 .. 0.61

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 1.7e-05
        SRA1   5 PssvaapppPsveavklsskeekslsesesepeledvlsvLnqaLeaCrksvkkqvcd.dvekrLrlledsW...ksGkLs...lpvrkrmevLs.... 92 
                 Ps   ++ +P+    +++ +++++  + +++ ++ ++ +++n   e C+++  +q ++ d+ + L+++       k+  L    +   + +++L+    
  EFC39081.1  70 PSENGTSTTPRKGQSPATPRTPRDNGKFDMDNNIVSLARIFNI--ELCHTEHDNQKFErDLMRMLKVISIVVvkkKQVALNsslIGYDSAVDLLAvndq 166
                 6666666677777777777777777777777777777777764..446665555544337777777665332100233332111223455666653333 PP

        SRA1  93 .qelqskrWdaaDdihrsLmvDhvtevs 119
                  +e+++ +W + D+i   L vD+++ + 
  EFC39081.1 167 pNEFEEIQWKSTDKITVQLFVDFINGIG 194
                 3699*******************99876 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.24
        SRA1  10 apppPsveavklsskeeksl 29 
                 +p +Ps++a+++ss ++k+ 
  EFC39081.1 428 TPSTPSSQAISTSSLKPKKN 447
                 34466666666666666443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       890  (0.0496402); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.29s 00:00:00.95 Elapsed: 00:00:00.48
# Mc/sec: 3007.05
//
Query:       EFC39082.1  [L=576]
Description: LRR_RI domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.1e-25   85.4  27.2     0.0011   18.8   0.1   11.4 12  LRR_6       Leucine Rich repeat
    1.5e-14   53.9  45.2    0.00011   22.5   0.3    8.4  9  LRR_4       Leucine Rich repeats (2 copies)
    1.5e-09   37.4  35.4      0.013   15.3   2.1    8.5  9  LRR_8       Leucine rich repeat
    7.1e-06   25.8   0.4    4.9e-05   23.1   0.1    2.7  2  F-box       F-box domain
    1.2e-05   25.2  23.0         20    6.2   0.0   10.5 11  LRR_1       Leucine Rich Repeat
    0.00019   21.2   1.1    0.00033   20.5   0.1    1.9  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   3.7e-07    0.0011       3      23 ..     193     213 ..     191     213 .. 0.94
   2 ?   -0.4   0.0      0.53   1.6e+03      12      24 .]     228     241 ..     220     241 .. 0.80
   3 !   16.8   0.0   1.7e-06     0.005       3      24 .]     247     268 ..     246     268 .. 0.94
   4 ?    2.6   0.0     0.059   1.8e+02       3      24 .]     274     295 ..     272     295 .. 0.79
   5 !    8.0   0.1    0.0011       3.3       3      21 ..     325     343 ..     323     343 .. 0.92
   6 !    7.1   0.4    0.0021       6.4       4      23 ..     353     372 ..     350     373 .. 0.83
   7 !   10.1   0.1   0.00023      0.68       2      24 .]     378     400 ..     377     400 .. 0.93
   8 ?   -2.5   0.0       2.6   7.7e+03      12      23 ..     415     426 ..     406     427 .. 0.73
   9 !   10.8   0.1   0.00013       0.4       3      23 ..     433     453 ..     431     454 .. 0.89
  10 ?   -0.8   0.0      0.74   2.2e+03       4      14 ..     461     471 ..     460     474 .. 0.82
  11 !    5.1   0.1    0.0094        28       3      21 ..     486     504 ..     485     505 .. 0.90
  12 !   14.9   0.0   6.6e-06      0.02       3      24 .]     513     534 ..     511     534 .. 0.93

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 3.7e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt+LdLs+NdI +e ++a+
  EFC39082.1 193 RTLTKLDLSYNDIHNEDIKAI 213
                 79***************9997 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.53
       LRR_6  12 gNd.IgDeGaeaLa 24 
                 +N+ ++ +Gae +a
  EFC39082.1 228 CNEsLTAKGAEYIA 241
                 78889999999887 PP

  == domain 3  score: 16.8 bits;  conditional E-value: 1.7e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++LteLdL +N ++DeG+e +a
  EFC39082.1 247 SNLTELDLDFNYLDDEGVEYIA 268
                 79*****************997 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.059
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L + + +++ + ++a +
  EFC39082.1 274 SKLTSLKVGDSGLTSQSISAVC 295
                 7899999999998888888765 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0011
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 ++Lt L++ +N I D+G++
  EFC39082.1 325 SKLTDLSIGCNIIEDKGMK 343
                 89***************96 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.0021
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt Ld+s+N ++D  ++ L
  EFC39082.1 353 NLTRLDVSCNIMTDISLILL 372
                 8*********9988777766 PP

  == domain 7  score: 10.1 bits;  conditional E-value: 0.00023
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  ++Lt Ld+  Nd++ +G+++++
  EFC39082.1 378 LSNLTDLDIGENDFTIKGMKSFC 400
                 589*****************998 PP

  == domain 8  score: -2.5 bits;  conditional E-value: 2.6
       LRR_6  12 gNdIgDeGaeaL 23 
                 + ++g++G+  L
  EFC39082.1 415 DLKFGNAGMLML 426
                 667899999877 PP

  == domain 9  score: 10.8 bits;  conditional E-value: 0.00013
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt+L+L++N ++ +G++ +
  EFC39082.1 433 KNLTHLSLQSNALTEDGLKVF 453
                 68***************9976 PP

  == domain 10  score: -0.8 bits;  conditional E-value: 0.74
       LRR_6   4 hLteLdLsgNd 14 
                 +L++Ld+ gN 
  EFC39082.1 461 NLKYLDMYGNP 471
                 79****98886 PP

  == domain 11  score: 5.1 bits;  conditional E-value: 0.0094
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 ++Lt+L+ s++ Ig++ ++
  EFC39082.1 486 PNLTYLNASSCSIGNDILS 504
                 69*************9887 PP

  == domain 12  score: 14.9 bits;  conditional E-value: 6.6e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L++L+L  N+I+ eG++ +a
  EFC39082.1 513 PKLKTLELELNKISSEGVKFIA 534
                 79****************9887 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1       0.3   8.9e+02       4      23 ..     163     183 ..     162     188 .. 0.77
   2 !   12.0   1.5   7.2e-05      0.21       3      33 ..     195     229 ..     193     235 .. 0.73
   3 !    7.9   0.2    0.0014       4.2      22      38 ..     246     261 ..     238     266 .. 0.81
   4 !    7.0   0.3    0.0028       8.2       2      30 ..     248     281 ..     247     299 .. 0.68
   5 ?    4.6   0.1     0.015        46      19      38 ..     321     339 ..     305     340 .. 0.72
   6 !   16.9   3.2   2.1e-06    0.0062       2      39 ..     353     391 ..     352     395 .. 0.84
   7 !   22.5   0.3   3.7e-08   0.00011       1      34 [.     433     471 ..     433     480 .. 0.82
   8 !   12.8   2.6   4.1e-05      0.12       1      37 [.     486     526 ..     486     529 .. 0.81
   9 !    6.3   0.6    0.0045        14       1      36 [.     513     552 ..     513     555 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.3
                 -EEE--SS---E-S-HH.H-T CS
       LRR_4   4 evLdLsnNqltdiplle.klp 23 
                 e+L +s N +++ip l+ +l+
  EFC39082.1 163 ENLQFSANLVQKIPVLRlNLK 183
                 67999978*******883344 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 7.2e-05
                 --EEE--SS---E-S-..HH..H.-TT--EEE-.-S CS
       LRR_4   3 LevLdLsnNqltdipl..le..k.lpnLkeLdLsgN 33 
                 L++LdLs N +   +   +   k l+nL++L L  N
  EFC39082.1 195 LTKLDLSYNDIHNEDIkaITqsKeLKNLTSLIL-CN 229
                 9******99988666655224555*******87.44 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.0014
                 -TT--EEE-.-S----- CS
       LRR_4  22 lpnLkeLdLsgNnlitd 38 
                 l nL+eLdL ++n+++d
  EFC39082.1 246 LSNLTELDL-DFNYLDD 261
                 99*******.6559876 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0028
                 S--EEE--SS---E-S-..HH...H-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdL 30 
                 nL++LdL  N l d +   ++    + +L++L +
  EFC39082.1 248 NLTELDLDFNYLDDEGVeyIAnshYMSKLTSLKV 281
                 7788888877777777754114634777777766 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.015
                 HHH-TT--EEE-.-S----- CS
       LRR_4  19 leklpnLkeLdLsgNnlitd 38 
                  +kl +L+ L++ g+n i+d
  EFC39082.1 321 SSKLSKLTDLSI-GCNIIED 339
                 347*********.9999876 PP

  == domain 6  score: 16.9 bits;  conditional E-value: 2.1e-06
                 S--EEE--SS---E-S-..HH...H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLsgNnlitdl 39 
                 nL+ Ld s N +tdi+l  l+   kl nL+ Ld+ +N    d+
  EFC39082.1 353 NLTRLDVSCNIMTDISLilLSncnKLSNLTDLDIGEN----DF 391
                 9*******98999****98335648*********889....66 PP

  == domain 7  score: 22.5 bits;  conditional E-value: 3.7e-08
                 SS--EEE--SS---E-S-HH.....H.-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdiplle.....k.lpnLkeLdLsgNn 34 
                 +nL++L+L++N lt+ ++l+     k + nLk+Ld+ gN+
  EFC39082.1 433 KNLTHLSLQSNALTE-DGLKvfsqsKtFENLKYLDMYGNP 471
                 7*************4.46555558866*********9993 PP

  == domain 8  score: 12.8 bits;  conditional E-value: 4.1e-05
                 SS--EEE--SS---.E-S-..HH..H-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqlt.dipl..le..klpnLkeLdLsgNnlit 37 
                 pnL++L+ s++ +  di +  ++   lp+Lk+L L + n+i+
  EFC39082.1 486 PNLTYLNASSCSIGnDILSkhFNsiELPKLKTLEL-ELNKIS 526
                 8*************776667755777********9.633654 PP

  == domain 9  score: 6.3 bits;  conditional E-value: 0.0045
                 SS--EEE--SS---E-S-..HH...H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le...klpnLkeLdLsgNnli 36 
                 p+L++L L  N++++ +   ++   kl +   ++L gNn +
  EFC39082.1 513 PKLKTLELELNKISSEGVkfIAkhkKLSKVDRIYL-GNNSL 552
                 79*******88***98889533564577788888*.76655 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.1     0.013        39      26      37 ..     194     205 ..     181     210 .. 0.67
   2 !   11.2   3.9   8.1e-05      0.24       1      61 []     193     259 ..     193     259 .. 0.84
   3 !    5.3   0.2    0.0056        17       1      19 [.     247     265 ..     247     293 .. 0.68
   4 ?    2.6   0.0     0.038   1.1e+02      24      46 ..     324     346 ..     306     352 .. 0.68
   5 !   11.2   3.1   8.1e-05      0.24       2      54 ..     326     381 ..     325     391 .. 0.82
   6 !   13.2   0.8   1.9e-05     0.058       2      47 ..     353     401 ..     352     409 .. 0.85
   7 !   14.5   1.3   7.5e-06     0.022      15      59 ..     423     470 ..     411     471 .. 0.80
   8 !   15.3   2.1   4.3e-06     0.013       2      61 .]     434     498 ..     433     498 .. 0.82
   9 !    4.5   1.8    0.0096        29      24      39 ..     512     527 ..     500     552 .. 0.65

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.013
                 T--EEE--SS-- CS
       LRR_8  26 nLkvLdLsnNll 37 
                  L+ LdLs+N +
  EFC39082.1 194 TLTKLDLSYNDI 205
                 455555555554 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 8.1e-05
                 TT-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS---GGGGGGGTT...--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllttlspgafsg...LpsLrsLdLsgNrL 61 
                 ++Lt+LdLs N +++ d +a ++   l+nL++L L n +lt   ++ ++    L++L++LdL+ N L
  EFC39082.1 193 RTLTKLDLSYNDIHNEDIKAITQskeLKNLTSLILCNESLTAKGAEYIAKskiLSNLTELDLDFNYL 259
                 68**********98766666543337*****************999988766699********9976 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.0056
                 TT-SEEE-TTS--SEE-TT CS
       LRR_8   1 pnLtsLdLsnNrltsldde 19 
                 +nLt+LdL++N+l + + e
  EFC39082.1 247 SNLTELDLDFNYLDDEGVE 265
                 5899999999999765544 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.038
                 -TT--EEE--SS---GGGGGGGT CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafs 46 
                 ls+L+ L++++N ++    + f+
  EFC39082.1 324 LSKLTDLSIGCNIIEDKGMKIFV 346
                 77777777777766655544444 PP

  == domain 5  score: 11.2 bits;  conditional E-value: 8.1e-05
                 T-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS---GGGGGGGTT--S-.EE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllttlspgafsgLpsLrsL 54 
                 +Lt L++ +N +++ + + F +     nL+ Ld s+N +t +s   +s++++L  L
  EFC39082.1 326 KLTDLSIGCNIIEDKGMKIFVNsnnIANLTRLDVSCNIMTDISLILLSNCNKLSNL 381
                 7999999999999999999976333678999******9999999999998887766 PP

  == domain 6  score: 13.2 bits;  conditional E-value: 1.9e-05
                 T-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS---GGGGGGGTT CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllttlspgafsg 47 
                 nLt+Ld+s+N  t+++    ++   lsnL+ Ld+++N  t    ++f  
  EFC39082.1 353 NLTRLDVSCNIMTDISLILLSNcnkLSNLTDLDIGENDFTIKGMKSFCE 401
                 8***************98887766699**********999988888876 PP

  == domain 7  score: 14.5 bits;  conditional E-value: 7.5e-06
                 EE-TTSSTT-TT--EEE--SS---GGGGGGGTT...--S-.EEE--SS CS
       LRR_8  15 slddeaFkglsnLkvLdLsnNllttlspgafsg...LpsLrsLdLsgN 59 
                  l  ++ ++++nL++L+L +N lt    ++fs+   +++L++Ld+ gN
  EFC39082.1 423 MLMLGSSSNMKNLTHLSLQSNALTEDGLKVFSQsktFENLKYLDMYGN 470
                 555678899****************99999998444578999998888 PP

  == domain 8  score: 15.3 bits;  conditional E-value: 4.3e-06
                 T-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS.---GGGGGGGTT..--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnN.llttlspgafsg..LpsLrsLdLsgNrL 61 
                 nLt L+L++N lt+ + ++F++   ++nLk+Ld+  N + + + ++ +++  Lp+L++L+ s++ +
  EFC39082.1 434 NLTHLSLQSNALTEDGLKVFSQsktFENLKYLDMYGNpCSSGI-RHILQSkfLPNLTYLNASSCSI 498
                 9*******************7644589**********665557.46655344********999875 PP

  == domain 9  score: 4.5 bits;  conditional E-value: 0.0096
                 -TT--EEE--SS---G CS
       LRR_8  24 lsnLkvLdLsnNlltt 39 
                 l++Lk+L+L  N++++
  EFC39082.1 512 LPKLKTLELELNKISS 527
                 7778888888877765 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.1   0.1   1.6e-08   4.9e-05       4      41 ..     128     166 ..     121     170 .. 0.92
   2 ?   -2.2   0.0       1.4   4.1e+03      16      30 ..     483     497 ..     476     498 .. 0.57

  Alignments for each domain:
  == domain 1  score: 23.1 bits;  conditional E-value: 1.6e-08
                 HHS-HHHHHHHHHTS-HHH.HHHHCTT-HHHHHHHTTHH CS
       F-box   4 srLPsevlrhILerLplsd.llalrrVSkgwrilidsdr 41 
                   +P+e+lr+I+ + +++d + + ++VS+ w  ++ ++ 
  EFC39082.1 128 KKVPPELLRNIFLFIDPIDiYQSVSQVSREWLTICENLQ 166
                 579*******************************98865 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.4
                 HTS-HHHHHHHCTT- CS
       F-box  16 erLplsdllalrrVS 30 
                 ++Lp  ++l+++++S
  EFC39082.1 483 KFLPNLTYLNASSCS 497
                 346666666666665 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.029        87       2      12 ..     195     205 ..     194     219 .. 0.81
   2 ?   -0.4   0.0      0.98   2.9e+03       1      16 [.     221     236 ..     221     242 .. 0.79
   3 !    6.2   0.0    0.0067        20       1      19 [.     248     266 ..     248     295 .. 0.82
   4 ?   -1.0   0.0       1.5   4.6e+03       1      16 [.     326     341 ..     326     347 .. 0.79
   5 ?    3.4   1.0     0.058   1.7e+02       1      17 [.     353     369 ..     353     378 .. 0.75
   6 ?    0.8   0.0       0.4   1.2e+03       1      20 [.     380     399 ..     380     403 .. 0.79
   7 ?    2.4   0.1      0.12   3.7e+02       1      12 [.     434     445 ..     434     456 .. 0.82
   8 ?    5.7   0.0      0.01        30       1      14 [.     461     474 ..     461     483 .. 0.76
   9 ?    5.2   0.3     0.015        44       1      20 [.     487     507 ..     487     511 .. 0.74
  10 ?    0.3   0.0      0.58   1.7e+03       1      14 [.     514     527 ..     514     535 .. 0.79
  11 ?   -0.5   0.0       1.1   3.3e+03       4      13 ..     544     553 ..     538     561 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.029
       LRR_1   2 LrhLdLsnnpl 12 
                 L++LdLs+n +
  EFC39082.1 195 LTKLDLSYNDI 205
                 99*******97 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.98
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 nL++L L+n +l+ ++
  EFC39082.1 221 NLTSLILCNESLTAKG 236
                 89*****999987655 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0067
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL++LdL  n l++ + ++
  EFC39082.1 248 NLTELDLDFNYLDDEGVEY 266
                 8**********96665544 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.5
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L+ L ++ n++++++
  EFC39082.1 326 KLTDLSIGCNIIEDKG 341
                 689999*999998775 PP

  == domain 5  score: 3.4 bits;  conditional E-value: 0.058
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL++Ld+s n+ ++++ 
  EFC39082.1 353 NLTRLDVSCNIMTDISL 369
                 8*********9765544 PP

  == domain 6  score: 0.8 bits;  conditional E-value: 0.4
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL+ Ld++ n ++ ++  sf
  EFC39082.1 380 NLTDLDIGENDFTIKGMKSF 399
                 8999****999976666665 PP

  == domain 7  score: 2.4 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+hL L +n l
  EFC39082.1 434 NLTHLSLQSNAL 445
                 8******99987 PP

  == domain 8  score: 5.7 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL++Ld+ +np ++
  EFC39082.1 461 NLKYLDMYGNPCSS 474
                 8*********9743 PP

  == domain 9  score: 5.2 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpl.lglppnsf 20 
                 nL++L+ s++++  ++++ +f
  EFC39082.1 487 NLTYLNASSCSIgNDILSKHF 507
                 8**********8755555555 PP

  == domain 10  score: 0.3 bits;  conditional E-value: 0.58
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++L L+ n +++
  EFC39082.1 514 KLKTLELELNKISS 527
                 7******9988754 PP

  == domain 11  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1   4 hLdLsnnpll 13 
                 +++L+nn+l+
  EFC39082.1 544 RIYLGNNSLD 553
                 5799***984 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.1   1.1e-07   0.00033       4      36 ..     130     163 ..     127     167 .. 0.91
   2 ?   -4.0   0.1       4.9   1.5e+04      23      30 ..     290     297 ..     289     298 .. 0.78

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.1e-07
  F-box-like   4 LPdEiLlqIFsyLppsdLlr.lalVCrrWrrval 36 
                  P+E+L  IF +++p d+++ +++V+r W +++ 
  EFC39082.1 130 VPPELLRNIFLFIDPIDIYQsVSQVSREWLTICE 163
                 5****************99999*********995 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 4.9
  F-box-like  23 rlalVCrr 30 
                 ++++VC++
  EFC39082.1 290 SISAVCSK 297
                 5799**85 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (576 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1203  (0.067098); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.45
# Mc/sec: 3804.51
//
Query:       EFC39083.1  [L=655]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.3e-08   33.7   0.7    3.3e-08   33.7   0.7    2.2  2  zf-rbx1       RING-H2 zinc finger domain
    1.3e-07   31.8   1.8    1.3e-07   31.8   1.8    2.6  2  zf-RING_2     Ring finger domain
    1.9e-06   27.6   2.9    1.9e-06   27.6   2.9    2.7  3  zf-C3HC4_2    Zinc finger, C3HC4 type (RING finger)
    1.3e-05   25.1   1.2    1.3e-05   25.1   1.2    2.2  2  zf-RING_5     zinc-RING finger domain
    1.6e-05   24.7   0.4    1.6e-05   24.7   0.4    1.7  2  Prok-RING_4   Prokaryotic RING finger family 4
    3.4e-05   23.6   7.6    4.4e-05   23.2   6.0    2.1  2  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
    0.00039   20.2   5.9     0.0007   19.4   0.6    2.4  2  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
     0.0007   19.6   0.2     0.0007   19.6   0.2    2.3  2  zf-RING_UBOX  RING-type zinc-finger
     0.0028   17.4   8.7     0.0077   16.0   0.4    3.0  3  zf-RING_11    RING-like zinc finger
     0.0043   17.1   0.2      0.011   15.8   0.2    1.8  1  zf-ANAPC11    Anaphase-promoting complex subunit 11 RING-H2 f
  ------ inclusion threshold ------
      0.048   14.2   0.1       0.15   12.6   0.1    1.9  1  LepB_GAP_C    LepB GAP domain C-terminal subdomain
        3.6    7.5   5.8       0.51   10.2   1.1    1.9  2  zf-RING_4     RING/Ubox like zinc-binding domain
          5    6.8  10.0      0.038   13.6   1.7    1.8  1  Zn_ribbon_17  Zinc-ribbon, C4HC2 type


Domain annotation for each model (and alignments):
>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.5       2.1   2.9e+03       2      13 ..     576     587 ..     575     596 .. 0.77
   2 !   33.7   0.7   2.4e-11   3.3e-08      25      55 .]     619     649 ..     597     649 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 2.1
     zf-rbx1   2 tCaiCrneleea 13 
                 +C iC +e+e +
  EFC39083.1 576 KCVICMSEIEIP 587
                 6****9999855 PP

  == domain 2  score: 33.7 bits;  conditional E-value: 2.4e-11
     zf-rbx1  25 cpvvlGeCgHaFHlhCiskWlktrkvCPlcr 55 
                    ++  C+H+FH+ C++kW + + +CPlc+
  EFC39083.1 619 KDFMVTPCNHVFHTVCLEKWKEYKLECPLCK 649
                 4566779***********************6 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   1.4      0.11   1.5e+02       2      13 ..     576     587 ..     575     594 .. 0.80
   2 !   31.8   1.8   9.7e-11   1.3e-07      12      44 .]     618     649 ..     613     649 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.11
   zf-RING_2   2 eCpICleelssa 13 
                 +C+IC++e++ +
  EFC39083.1 576 KCVICMSEIEIP 587
                 7******99755 PP

  == domain 2  score: 31.8 bits;  conditional E-value: 9.7e-11
   zf-RING_2  12 sadsvlllpCgHvfhreClerwlrssstCPlCr 44 
                 s+d  +++pC+Hvfh  Cle+w + + +CPlC+
  EFC39083.1 618 SKD-FMVTPCNHVFHTVCLEKWKEYKLECPLCK 649
                 433.34568***********************7 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       7.2   9.9e+03      16      21 ..     303     308 ..     299     309 .. 0.76
   2 ?    2.5   0.2     0.099   1.4e+02       1      12 [.     576     587 ..     576     591 .. 0.87
   3 !   27.6   2.9   1.4e-09   1.9e-06      13      40 .]     621     648 ..     617     648 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 7.2
  zf-C3HC4_2  16 tpCgHv 21 
                 ++C+H+
  EFC39083.1 303 INCNHT 308
                 58***7 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.099
  zf-C3HC4_2   1 kCpiCldmlkdp 12 
                 kC iC+ +++ p
  EFC39083.1 576 KCVICMSEIEIP 587
                 7******99866 PP

  == domain 3  score: 27.6 bits;  conditional E-value: 1.4e-09
  zf-C3HC4_2  13 svvtpCgHvfCqkCilrsLeekneCPlC 40 
                  +vtpC+Hvf+  C+ ++ e k eCPlC
  EFC39083.1 621 FMVTPCNHVFHTVCLEKWKEYKLECPLC 648
                 599**************755555***** PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1       1.1   1.5e+03       1       9 [.     576     584 ..     574     599 .. 0.73
   2 !   25.1   1.2   9.2e-09   1.3e-05       7      44 .]     614     650 ..     604     650 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.1
   zf-RING_5   1 hCnkCfekl 9  
                 +C +C++++
  EFC39083.1 576 KCVICMSEI 584
                 588888877 PP

  == domain 2  score: 25.1 bits;  conditional E-value: 9.2e-09
   zf-RING_5   7 eklskeekfyltsCgHifCekClkkllekeavCpiCrk 44 
                 e++ ++++f++t+C H+f+  Cl k +e + +Cp+C+k
  EFC39083.1 614 ENY-SSKDFMVTPCNHVFHTVCLEKWKEYKLECPLCKK 650
                 567.8899*******************9********97 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.5       5.3   7.3e+03       1       6 [.     577     582 ..     575     591 .. 0.67
   2 !   24.7   0.4   1.1e-08   1.6e-05       7      40 ..     617     652 ..     606     654 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 5.3
  Prok-RING_4   1 CvlCge 6  
                  Cv+C +
   EFC39083.1 577 CVICMS 582
                  555544 PP

  == domain 2  score: 24.7 bits;  conditional E-value: 1.1e-08
  Prok-RING_4   7 qekkailepCgHlvCkeCfdskdls..sCPlCqrri 40 
                  + k+ ++ pC+H++   C+++++     CPlC++ +
   EFC39083.1 617 SSKDFMVTPCNHVFHTVCLEKWKEYklECPLCKKDL 652
                  478999***************9554499****9975 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       3.6     5e+03      15      20 ..     303     308 ..     296     310 .. 0.80
   2 !   23.2   6.0   3.2e-08   4.4e-05       1      41 []     577     648 ..     577     648 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 3.6
                 -TTS-- CS
    zf-C3HC4  15 leCkHs 20 
                 ++C+H+
  EFC39083.1 303 INCNHT 308
                 78***8 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 3.2e-08
                 -TTT-S--SS-E..................................E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepn.................................elleCkHsfCskCirkilksrkkvkCPlC 41 
                 C iC++e+++p                                  ++++C+H f++ C++k+ +   k +CPlC
  EFC39083.1 577 CVICMSEIEIPEndttsdallvevnnnstltnrkkkaenysskdfMVTPCNHVFHTVCLEKWKE--YKLECPLC 648
                 99*******999999*************************************************..9999**** PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.5     0.066        91      37      47 ..     574     584 ..     567     587 .. 0.64
   2 !   19.4   0.6   5.1e-07    0.0007      12      46 ..     618     651 ..     614     654 .. 0.91

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.066
                 T-B-TTT--B- CS
  zf-C3HC4_3  37 kkkCpiCrrpi 47 
                 ++kC iC ++i
  EFC39083.1 574 ECKCVICMSEI 584
                 55666666655 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 5.1e-07
                 BS-EEETTEEEEEE-HHHHHHHHHTT-B-TTT--B CS
  zf-C3HC4_3  12 prnvvllpCgHlvlCeeCaekllkrkkkCpiCrrp 46 
                  +++++ pC+H+ +   C+ek+++ k +Cp+C+++
  EFC39083.1 618 SKDFMVTPCNHV-FHTVCLEKWKEYKLECPLCKKD 651
                 68999*******.*********99********986 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.2       1.5   2.1e+03       1      11 [.     577     587 ..     562     598 .. 0.82
   2 !   19.6   0.2   5.1e-07    0.0007      12      39 .]     622     646 ..     603     646 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.5
  zf-RING_UBOX   1 CpIClelftdP 11 
                   C IC+++ + P
    EFC39083.1 577 CVICMSEIEIP 587
                   77888776655 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 5.1e-07
  zf-RING_UBOX  12 lvlpCGHtFCreClwelskslegafkCP 39 
                   +v+pC H+F+  Cl    k++e ++ CP
    EFC39083.1 622 MVTPCNHVFHTVCL---EKWKEYKLECP 646
                   6789**********...99********9 PP

>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       7.1   9.8e+03      19      23 ..     304     308 ..     302     308 .. 0.83
   2 !    6.0   0.5    0.0072        10       2      10 ..     577     585 ..     576     592 .. 0.82
   3 !   16.0   0.4   5.6e-06    0.0077      14      29 .]     620     635 ..     614     635 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 7.1
  zf-RING_11  19 pCsHt 23 
                  C+Ht
  EFC39083.1 304 NCNHT 308
                 5***7 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0072
  zf-RING_11   2 CsICLeefk 10 
                 C+IC++e++
  EFC39083.1 577 CVICMSEIE 585
                 ********9 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 5.6e-06
  zf-RING_11  14 alfilpCsHtFHfkCI 29 
                   +++pC+H+FH  C+
  EFC39083.1 620 DFMVTPCNHVFHTVCL 635
                 56899********995 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.2   7.9e-06     0.011      47      81 ..     621     652 ..     576     655 .] 0.85

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 7.9e-06
                 EEEBTTS-EEEHHHHHHHHHHHSTSSB-TTTSSB- CS
  zf-ANAPC11  47 lvlGkckhnfhlhcilkwletetskglcpmcrqtf 81 
                 +++  c+h+fh+ c+ kw e    k  cp+c++ +
  EFC39083.1 621 FMVTPCNHVFHTVCLEKWKE---YKLECPLCKKDL 652
                 56678*************65...6789****9865 PP

>> LepB_GAP_C  LepB GAP domain C-terminal subdomain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   0.00011      0.15      19      81 ..     573     639 ..     561     640 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00011
                 HHHHHHHHHHHT....TSSS--HHHHHHHTTTHHHHHHHHHHTS..STTTT--S-HHHHHHHHHHHH CS
  LepB_GAP_C  19 GaqLatiCleEl....eaaepSlLlvrivkddtlwqrlkealsekksaFeaReDnpeeKiaklaelr 81 
                 G+    iC+ E+    +++++ +Llv + +++tl +r k+a + + + F+    n    +++l +++
  EFC39083.1 573 GECKCVICMSEIeipeNDTTSDALLVEVNNNSTLTNRKKKAENYSSKDFMVTPCNHVFHTVCLEKWK 639
                 666678******999999999********************99999999988877777777777776 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.3       2.2     3e+03      22      26 ..     577     581 ..     570     591 .. 0.62
   2 ?   10.2   1.1   0.00037      0.51      12      46 ..     618     651 ..     611     652 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.2
   zf-RING_4  22 yqiCl 26 
                 + iC+
  EFC39083.1 577 CVICM 581
                 44443 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00037
   zf-RING_4  12 dkdlkpCeCgyqiClfCyhrileeeegrCPaCree 46 
                  kd++  +C++ +   C+++ +e  +  CP C+++
  EFC39083.1 618 SKDFMVTPCNHVFHTVCLEKWKE-YKLECPLCKKD 651
                 57788889999999999999996.799******85 PP

>> Zn_ribbon_17  Zinc-ribbon, C4HC2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   1.7   2.8e-05     0.038      20      46 ..     622     646 ..     617     649 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 2.8e-05
  Zn_ribbon_17  20 lcgvCeHvlHasCarewfenddlaeCp 46 
                   + + C+Hv H+ C+++w e +   eCp
    EFC39083.1 622 MVTPCNHVFHTVCLEKWKEYKL--ECP 646
                   5678*************88887..887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (655 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1258  (0.0701657); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.76u 0.32s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 3777.03
//
Query:       EFC39084.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       385  (0.0214736); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.35s 00:00:00.89 Elapsed: 00:00:00.55
# Mc/sec: 670.02
//
Query:       EFC39085.1  [L=548]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (548 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       572  (0.0319036); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 3166.58
//
Query:       EFC39086.1  [L=168]
Description: methionine-r-sulfoxide reductase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.8e-48  161.5   0.3    9.9e-48  161.2   0.3    1.1  1  SelR             SelR domain
    0.00026   21.1   0.9     0.0016   18.6   0.9    2.1  1  Yippee-Mis18     Yippee zinc-binding/DNA-binding /Mis18, cent
      0.007   16.1   1.0      0.027   14.2   0.2    2.0  2  zinc_ribbon_10   Predicted integral membrane zinc-ribbon meta
  ------ inclusion threshold ------
       0.11   11.4   0.6          2    7.2   0.6    2.1  1  HECT_2           HECT-like Ubiquitin-conjugating enzyme (E2)-
       0.19   12.1   1.2        9.5    6.7   1.2    2.3  1  Lar_restr_allev  Restriction alleviation protein Lar


Domain annotation for each model (and alignments):
>> SelR  SelR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  161.2   0.3   2.8e-51   9.9e-48       1     120 [.      39     166 ..      39     167 .. 0.95

  Alignments for each domain:
  == domain 1  score: 161.2 bits;  conditional E-value: 2.8e-51
                 HHHCTSHCCHHHHHHHTT-SSTTSSSTS........S--SSCEEEETTTS-EEEECCCCE-STTSSSEESS-STTTTEEEEEEECTTSEEEEEEETTCE CS
        SelR   1 elkkkLtpeqyevlrekgterpftgeye........kekekGvyecavcgepLfssetkfdsgcGwpsFaeaikeeavkekkdtslgmertevvcakcd 91 
                 e+ k Lt++qyevlr++gte++f++ y+        +++e+Gv++c +c++pLfs++t fdsg+GwpsF++++k +a+ ++ d+++gmer+evvc++c+
  EFC39086.1  39 EWMKILTSKQYEVLRRAGTEPSFCSGYKvfkdqlkeNNQEEGVFHCSGCDAPLFSAKTSFDSGSGWPSFWAPFKPKAIGYVVDKKFGMERVEVVCTNCH 137
                 79*********************999997777777677888********************************************************** PP

                 CEEEEEECTSSSSS.SEEEEE-CCCEEEE CS
        SelR  92 ahlGhvFedgpkpttgkrycinsvslkfk 120
                 +hlGhvFedgp+++t++rycin+v+l++k
  EFC39086.1 138 SHLGHVFEDGPRDKTKLRYCINAVCLALK 166
                 **************************976 PP

>> Yippee-Mis18  Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.9   4.4e-07    0.0016       2      88 ..      81     166 ..      80     168 .] 0.72

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 4.4e-07
                   EEEETTTS-EEEECCCEEEEECCCEEEE..S---CCCEEEECEEEETTSTTEEEEEEEETTT--EEEEEEEECSCC...CCCCCTCEEEEGG CS
  Yippee-Mis18   2 vfqCkkCktilgdslqlvsegralnivv..lkkvtrnvvvgkelvtdeegkctystlsCkgCnsvlGwkYksteee...lkykrglfiletk 88 
                   vf+C+ C ++l  +   +++g  +  +   +k+ +   vv+k+  ++        ++ C++C+s+lG ++++ +++   l+y+++  +l  k
    EFC39086.1  81 VFHCSGCDAPLFSAKTSFDSGSGWPSFWapFKPKAIGYVVDKKFGME------RVEVVCTNCHSHLGHVFEDGPRDktkLRYCINAVCLALK 166
                   89999999999999999998888555541145555555566666666......678****************99873346677777777665 PP

>> zinc_ribbon_10  Predicted integral membrane zinc-ribbon metal-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.21   7.6e+02      39      51 ..      76      88 ..      70      90 .. 0.72
   2 !   14.2   0.2   7.4e-06     0.027      17      41 ..     125     152 ..     114     162 .. 0.75

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.21
  zinc_ribbon_10 39 eleevkyrCpkCg 51
                    + ee  + C+ C 
      EFC39086.1 76 NQEEGVFHCSGCD 88
                    4556689999996 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 7.4e-06
  zinc_ribbon_10  17 aknryalICskChshnGlap...keele 41 
                      ++r+ ++C++Chsh G +    +++++
      EFC39086.1 125 GMERVEVVCTNCHSHLGHVFedgPRDKT 152
                     568999***********99755555555 PP

>> HECT_2  HECT-like Ubiquitin-conjugating enzyme (E2)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.6   0.00056         2     203     225 ..     121     143 ..      31     161 .. 0.69

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.00056
      HECT_2 203 eetkpkkeeslsCkrCkatlGee 225
                 +++  ++++++ C++C+++lG++
  EFC39086.1 121 DKKFGMERVEVVCTNCHSHLGHV 143
                 56666788889999999999976 PP

>> Lar_restr_allev  Restriction alleviation protein Lar
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   1.2    0.0026       9.5       8      37 ..      61      93 ..      60     157 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0026
  Lar_restr_allev  8 fCggravlersqrvvaeigqcvyCadCga...s 37
                     fC g +v + + +  ++ + +++C  C a   s
       EFC39086.1 61 FCSGYKVFKDQLKENNQEEGVFHCSGCDAplfS 93
                     788888877777777766667777777773331 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       816  (0.0455129); expected 358.6 (0.02)
Passed bias filter:                      676  (0.0377043); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.58u 0.35s 00:00:00.93 Elapsed: 00:00:00.55
# Mc/sec: 925.36
//
Query:       EFC39087.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-06   28.6   4.2    1.1e-06   28.6   4.2    3.1  2  zf-B_box        B-box zinc finger
     0.0024   17.4   4.0     0.0034   16.9   4.0    1.2  1  Golgin_A5       Golgin subfamily A member 5
  ------ inclusion threshold ------
       0.12   12.2   1.9       0.18   11.7   1.9    1.3  1  Apolipoprotein  Apolipoprotein A1/A4/E domain
       0.85    9.7   4.8        2.4    8.2   4.7    1.9  1  Nup54           Nucleoporin complex subunit 54
        3.8    8.3   5.8        3.3    8.4   0.9    2.4  2  MUG113          Meiotically up-regulated gene 113


Domain annotation for each model (and alignments):
>> zf-B_box  B-box zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.6  10.8         5   1.8e+04      11      40 ..      18      49 ..       3      51 .. 0.57
   2 !   28.6   4.2   3.1e-10   1.1e-06       2      41 ..      65     104 ..      64     105 .. 0.93

  Alignments for each domain:
  == domain 1  score: -5.6 bits;  conditional E-value: 5
    zf-B_box 11 nkpatlfCedCqq.plCeeCstgeHr.g.Hevv 40
                +  at  C +C+   lC+    ++H+ + H+++
  EFC39087.1 18 ELLATHSCSTCSLkDLCSYH-AKKHErNlHQII 49
                34567777777765677665.777774367776 PP

  == domain 2  score: 28.6 bits;  conditional E-value: 3.1e-10
    zf-B_box   2 eetkCpeHknkpatlfCedCqqplCeeC.stgeHrgHevvp 41 
                 +++ C++H   p++ +C dC++++C++C  +g H +H ++ 
  EFC39087.1  65 KAPFCKDHF-IPINCYCSDCNVLICSTCiVSGGHLTHGISL 104
                 6789*****.***************************9875 PP

>> Golgin_A5  Golgin subfamily A member 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   4.0   9.6e-07    0.0034      48     156 ..     105     209 ..      92     234 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 9.6e-07
   Golgin_A5  48 eldelkqerdllreelqklnqqieqlrtelqdleaqqqaeaeslreqlqeleeqleeerkakeeveaelerlkeelryleeelvrskatlqsrikdrek 146
                   + +++er+++ eel+++ +++e+ r+  q  e++  ae+e+++ + +ele+q++ +     e++++l + k+el +    +v+ +  +++ + +++ 
  EFC39087.1 105 ISEVVMKERKIIGEELERFINRVEEWRSIHQMEENHLLAEIEKVKTKGKELEKQIHLKF---DELHNNLTSRKQELITQVYSVVERQCAIVNYV-KKNV 199
                 457789*********************98788888999******************665...56779999999999999999998888888877.6788 PP

   Golgin_A5 147 eieklrnqlt 156
                 ++e+l+++ +
  EFC39087.1 200 NVEELKQEFK 209
                 9999988876 PP

>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   1.9     5e-05      0.18      42     119 ..     116     192 ..     105     233 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 5e-05
                     HHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHCCHHCHCCHCHHHHHHHHHHHHHHHHHH CS
  Apolipoprotein  42 lraeleevrarlepyrdevqeqlgqnleelrqrlapyteelrerlaadaeelqeqlavyaeelrerlerhvealkarl 119
                     +++ele   +r+e+ r  ++++ + +l +  +++++  +el +++ ++ +el + l++ ++el +++ + ve++ a +
      EFC39087.1 116 IGEELERFINRVEEWR-SIHQMEENHLLAEIEKVKTKGKELEKQIHLKFDELHNNLTSRKQELITQVYSVVERQCAIV 192
                     5777777778877655.57888888888888999**************************998777766666655544 PP

>> Nup54  Nucleoporin complex subunit 54
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   4.7   0.00068       2.4      46     119 ..     139     211 ..     111     214 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00068
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.HHTT-SS---SSHHHHHHHHHHH CS
       Nup54  46 aqhrerlkeisdrleeleqkhqletsvrlekakkrhvelshRllrllrkle.ilrsrgyaldaeEeelrarletl 119
                 + +   +++++++ +ele++ +l+  +  +++ +r++el++++++++ ++  i+++ +++++   eel++++++l
  EFC39087.1 139 NHLLAEIEKVKTKGKELEKQIHLKFDELHNNLTSRKQELITQVYSVVERQCaIVNYVKKNVN--VEELKQEFKDL 211
                 455677999**************************************999956677777766..67788888776 PP

>> MUG113  Meiotically up-regulated gene 113
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.3      0.12   4.3e+02      19      46 ..      10      47 ..       4      50 .. 0.78
   2 ?    8.4   0.9   0.00093       3.3      11      56 ..     125     171 ..     121     193 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.12
      MUG113 19 qc..pskltllryyppss........pnahrlErllhl 46
                +c  + + +ll+++++s          +a++ Er lh+
  EFC39087.1 10 TCleEENEELLATHSCSTcslkdlcsYHAKKHERNLHQ 47
                5566677788888888888888888889*********8 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00093
      MUG113  11 rRlnelnrqc.pskltllryyppsspnahrlErllhleLkdkrlrde 56 
                 +R+ e+ +   + +  ll+ ++  + + ++lE+++hl++ +   + +
  EFC39087.1 125 NRVEEWRSIHqMEENHLLAEIEKVKTKGKELEKQIHLKFDELHNNLT 171
                 69999998777777788888888889*************99776664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2101  (0.117184); expected 358.6 (0.02)
Passed bias filter:                      648  (0.0361426); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 1595.59
//
Query:       EFC39088.1  [L=457]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.6e-18   66.4  20.2      3e-11   43.2   4.0    2.1  2  TPT          Triose-phosphate Transporter family
    1.4e-06   28.6   4.2    1.4e-06   28.6   4.2    3.9  3  EamA         EamA-like transporter family
    2.5e-05   23.6  24.4    0.00023   20.5   5.7    2.3  2  UAA          UAA transporter family
    0.00016   21.0   9.6    0.00016   21.0   9.6    2.4  2  PUNUT        Purine nucleobase transmembrane transport
  ------ inclusion threshold ------
       0.34   10.8   3.0        0.9    9.4   3.0    1.7  1  SUB1_ProdP9  SUB1 protease Prodomain ProdP9
        6.9    6.3   6.8         13    5.5   1.8    2.7  2  DUF2244      Integral membrane protein (DUF2244)


Domain annotation for each model (and alignments):
>> TPT  Triose-phosphate Transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.2   4.0     1e-14     3e-11      60     171 ..     144     255 ..      75     278 .. 0.89
   2 !   29.2   8.3   1.9e-10   5.6e-07     173     289 ..     316     445 ..     301     446 .. 0.87

  Alignments for each domain:
  == domain 1  score: 43.2 bits;  conditional E-value: 1e-14
         TPT  60 isseflkailplalvktlghvlavvslskvaVSfthtvKasePiFtvilsrlllgeklsllvylsLlpivgGvalasvtElsFnligfisAlisnltfs 158
                 ++++ +k++ p +++  +    +++ l+ +++S   ++K+s P+F  i+s +   ek+++ +++s++ i  Gv ++s   ++F++igf+  +++ ++ +
  EFC39088.1 144 FNWNSFKSLAPFGVLTGFDYACSTLGLKFITISLYTMLKSSVPVFVMIISFICKMEKVKFILIISIVLISIGVGMTSKGTIHFDIIGFVLVMVAVVFTA 242
                 4567899999999************************************************************************************** PP

         TPT 159 lrnifsKkllkkl 171
                 lr +++  +l+ +
  EFC39088.1 243 LRLVIAQYVLQRS 255
                 *******999982 PP

  == domain 2  score: 29.2 bits;  conditional E-value: 1.9e-10
         TPT 173 dldalnlfaiitilslllllPvallveg..vlktpsllkst..........kvs.lkevllllllsgvlfhlynqvaymvLervspvthsvantvKrvv 258
                 +++++++f++++ + +l +lP+al++e   +  + s+l+++          ++  + ++++++++ ++l  + n+  + +++++s +t +v +  K  +
  EFC39088.1 316 EISSVQIFFYTAPVIALTVLPIALILELnsIISVFSNLQQAvdathsihmlRFLfILKFVAMVFVGSMLGIILNVSEFLLIKQTSSLTLTVLSIFKELL 414
                 48999**********************9885555555555567778887765334789999999999999***************************** PP

         TPT 259 vIvlsvlvfknpvsllnaiGtavaivGvflY 289
                 +I+++v++f++++ +l  iG  + ++G ++Y
  EFC39088.1 415 MIAIAVMIFGDHIGVLGYIGYGLCLIGLIIY 445
                 *****************************99 PP

>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.6   4.2   4.5e-10   1.4e-06      57     135 ..     142     219 ..     128     221 .. 0.89
   2 ?    2.7   0.3     0.045   1.4e+02       2      31 ..     229     258 ..     228     265 .. 0.85
   3 ?    3.6  18.0     0.023        69      28     134 ..     317     444 ..     310     446 .. 0.75

  Alignments for each domain:
  == domain 1  score: 28.6 bits;  conditional E-value: 4.5e-10
        EamA  57 aklslkdwllllllgllgtvlafllffyalkktsasnaslitslePvftlilsvlllgekltlkqllgivlillGvlli 135
                   ++++++++l+ +g+l ++  + + + +lk ++ s  +++ s +Pvf++i+s++   ek++++ +++ivli +Gv ++
  EFC39088.1 142 HLFNWNSFKSLAPFGVLTGFD-YACSTLGLKFITISLYTMLKSSVPVFVMIISFICKMEKVKFILIISIVLISIGVGMT 219
                 4789***********876665.589999************************************************887 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.045
        EamA   2 lgillallaalfwaiyfvlskillrkvspl 31 
                 +g +l+++a++f a+  v+++++l++ +++
  EFC39088.1 229 IGFVLVMVAVVFTALRLVIAQYVLQRSNTQ 258
                 68899999999*999999999999988876 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.023
        EamA  28 vspltltfvrfliagillliiallkegkl..aklslkd...................wllllllgllgtvlafllffyalkktsasnaslitslePvft 105
                 +s+++++f++  + ++ +l+ial+ e +   +++s  +                   + +++++g + +++ ++  f ++k ts+ + ++++ +  +++
  EFC39088.1 317 ISSVQIFFYTAPVIALTVLPIALILELNSiiSVFSNLQqavdathsihmlrflfilkFVAMVFVGSMLGIILNVSEFLLIKQTSSLTLTVLSIFKELLM 415
                 566777777777777777777666666664422222224445555666666666554556677777888888899************************ PP

        EamA 106 lilsvlllgekltlkqllgivlillGvll 134
                 + ++v ++g +++++ ++g +l+l+G+++
  EFC39088.1 416 IAIAVMIFGDHIGVLGYIGYGLCLIGLII 444
                 **************************986 PP

>> UAA  UAA transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   5.7   7.8e-08   0.00023      76     168 ..     163     243 ..      83     263 .. 0.82
   2 !    9.1  10.8   0.00023      0.69     200     299 ..     339     446 ..     312     449 .. 0.71

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 7.8e-08
         UAA  76 svlnnealkydisvPvhiifrssklipvmilGililgkrYsllqylsvllltlGviiftllsakdkkedskeslnkfllGiallvlallldav 168
                  +++   lk+ i + + ++++ss  + vmi++ +    + +++ ++s++l+++Gv + +             +  + ++G++l+++a++++a+
  EFC39088.1 163 YACSTLGLKF-ITISLYTMLKSSVPVFVMIISFICKMEKVKFILIISIVLISIGVGMTSK-----------GTIHFDIIGFVLVMVAVVFTAL 243
                 5788889***.********************************************98654...........5678889999999999999986 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00023
         UAA 200 l.llqgellsavkflsesedval.......lslpsklfylllnvltqyvcikgVlilisefgaltvtlvltlRKfvslllSillFknpltlqhlvgtll 290
                 l l  ++++s +  l++  d++        l + + + ++++ ++++ +   + ++li+++++lt+t+      ++ + + +++F+ ++ +  ++g  l
  EFC39088.1 339 LiLELNSIISVFSNLQQAVDATHsihmlrfLFILKFVAMVFVGSMLGIILNVSEFLLIKQTSSLTLTVLSIFKELLMIAIAVMIFGDHIGVLGYIGYGL 437
                 34444445555555555444444422322255556666666667777777777799******************************************* PP

         UAA 291 Vflglllys 299
                  ++gl++y 
  EFC39088.1 438 CLIGLIIYK 446
                 *****9986 PP

>> PUNUT  Purine nucleobase transmembrane transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   9.6   5.3e-08   0.00016      79     192 ..     153     257 ..     130     265 .. 0.86
   2 !    5.5   4.0    0.0029       8.5     255     318 ..     388     451 ..     367     455 .. 0.85

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 5.3e-08
       PUNUT  79 ivlGllvavdnllyslgllylpvstfslilatqLaFtaifsalinkqkftrfiinsvvlltisaallalssssdkpaeeskkkyvigfiltlaasllfa 177
                    G+l+++d   + lgl+ + +s ++++ ++  +F  i+s++    k+ +  i+s+vl++i+  +++    ++ +     +  +igf+l+++a ++ a
  EFC39088.1 153 APFGVLTGFDYACSTLGLKFITISLYTMLKSSVPVFVMIISFICKMEKVKFILIISIVLISIGVGMTS----KG-TI----HFDIIGFVLVMVAVVFTA 242
                 5579***********************************************************99887....23.23....3448************** PP

       PUNUT 178 LlLslvellfekvlk 192
                 L L + +++ ++  +
  EFC39088.1 243 LRLVIAQYVLQRSNT 257
                 ********9998765 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0029
       PUNUT 255 lavGavgLvflvSslfsnvistvllpvvsvlavilfrdkfsavkgvalllailgfasYvYgeyk 318
                 l v    L+  +Ssl+  v+s+    +   +av++f d++++   +   l+++g++ Y  + + 
  EFC39088.1 388 LNVSEFLLIKQTSSLTLTVLSIFKELLMIAIAVMIFGDHIGVLGYIGYGLCLIGLIIYKVHRFL 451
                 5566677999**********************************************99766655 PP

>> SUB1_ProdP9  SUB1 protease Prodomain ProdP9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   3.0    0.0003       0.9      31      73 ..      47      89 ..      27      94 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0003
  SUB1_ProdP9 31 skGklanlknlksiiielkedttdeelieyikileekGalies 73
                 +  +  n kn++ +ii+ +e+  d+ + +  + +eekG l e+
   EFC39088.1 47 TNNDQLNNKNVENVIINNNEEEEDDPISNIEENVEEKGLLQET 89
                 45555688******************999999******99885 PP

>> DUF2244  Integral membrane protein (DUF2244)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   1.8    0.0042        13      13      58 ..     201     248 ..     197     257 .. 0.85
   2 ?    2.5   0.2     0.036   1.1e+02      18      59 ..     408     450 ..     398     455 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0042
     DUF2244  13 lllllalalvslvialafllaGawp..vlpFaglevlalalafrvsar 58 
                 + ++l++ +v++ i++++++ G     +++F+++ v+++  a+r++  
  EFC39088.1 201 VKFILIISIVLISIGVGMTSKGTIHfdIIGFVLVMVAVVFTALRLVIA 248
                 5689999999999999999999865459***************99875 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.036
     DUF2244  18 alalvslvialafllaG.awpvlpFaglevlalalafrvsarh 59 
                 +++  +l+ia+a+++ G    vl+++g  + +++l+++ + r 
  EFC39088.1 408 SIFKELLMIAIAVMIFGdHIGVLGYIGYGLCLIGLIIYKVHRF 450
                 444456777888776652678**************99998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (457 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1408  (0.078532); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 2746.35
//
Query:       EFC39089.1  [L=105]
Description: TM2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-19   68.3   6.1    7.6e-19   67.8   6.1    1.2  1  TM2       TM2 domain


Domain annotation for each model (and alignments):
>> TM2  TM2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.8   6.1   4.2e-23   7.6e-19       2      50 ..       4      51 ..       3      52 .. 0.96

  Alignments for each domain:
  == domain 1  score: 67.8 bits;  conditional E-value: 4.2e-23
         TM2  2 kksklvaylLwffLGglGvHRFYlGktgsGvlqlltfvGglgiwwlidl 50
                +k+  +aylLwff G+lG+HRFYl  + +G++++lt+ G++gi+wlid+
  EFC39089.1  4 EKDVMIAYLLWFFVGMLGIHRFYLDSPVMGIVYFLTG-GLCGIGWLIDI 51
                69999********************************.**********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (105 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       425  (0.0237046); expected 358.6 (0.02)
Passed bias filter:                      259  (0.0144459); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.46u 0.30s 00:00:00.76 Elapsed: 00:00:00.48
# Mc/sec: 664.14
//
Query:       EFC39090.1  [L=220]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.063   13.4   0.9        0.1   12.7   0.9    1.3  1  DUF212    Divergent PAP2 family


Domain annotation for each model (and alignments):
>> DUF212  Divergent PAP2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.9   5.7e-06       0.1      34      59 ..      92     118 ..      74     134 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.7e-06
      DUF212  34 kllvstGgmPSsHsal.vtalatavgl 59 
                  +l +tGgmP sHs+  +++ + +vg+
  EFC39090.1  92 GYLSTTGGMPHSHSSSsIASATSSVGV 118
                 56889*********9934455555665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       702  (0.0391544); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1419.85
//
Query:       EFC39091.1  [L=1113]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      3e-69  233.3   0.0    2.3e-68  230.4   0.0    2.1  2  Peptidase_C2  Calpain family cysteine protease
    1.7e-15   56.1   9.8    4.6e-05   23.1   0.0    8.0  8  TPR_1         Tetratricopeptide repeat
    1.1e-13   50.1   1.2     0.0014   18.6   0.0    7.2  6  TPR_2         Tetratricopeptide repeat
    1.6e-11   43.5   8.1     0.0086   16.2   0.1    7.2  6  TPR_8         Tetratricopeptide repeat
      2e-10   40.8   2.0      0.028   14.7   0.0    6.1  6  TPR_12        Tetratricopeptide repeat
    6.4e-10   38.7   0.4    0.00074   19.7   0.0    5.9  5  TPR_17        Tetratricopeptide repeat
    7.2e-08   32.0   4.4       0.11   12.2   0.0    5.9  6  TPR_11        TPR repeat
    4.2e-07   30.0   0.0      0.011   15.8   0.0    3.7  3  TPR_9         Tetratricopeptide repeat
    8.3e-07   29.4   0.1    9.9e-06   25.9   0.0    2.7  2  Calpain_III   Calpain large subunit, domain III
    1.1e-06   29.0   0.0    7.2e-05   23.2   0.0    3.8  5  TPR_19        Tetratricopeptide repeat
      8e-05   23.2   0.0       0.63   11.0   0.0    4.6  3  TPR_14        Tetratricopeptide repeat
    0.00017   21.9   0.1     0.0017   18.7   0.1    2.7  2  TPR_20        Tetratricopeptide repeat
     0.0026   18.3   0.1        3.5    8.5   0.0    5.2  5  TPR_6         Tetratricopeptide repeat
     0.0047   16.3   0.2        6.2    6.4   0.0    3.4  3  SHNi-TPR      SHNi-TPR
     0.0094   15.1   0.0       0.63    9.1   0.0    3.2  4  DUF4437       Domain of unknown function (DUF4437)
  ------ inclusion threshold ------
      0.011   15.6   0.3        3.1    7.8   0.0    4.3  5  TPR_10        Tetratricopeptide repeat
       0.09   12.9   1.4        2.7    8.1   0.1    3.3  3  CNOT11        CCR4-NOT transcription complex subunit 11
        0.1   12.7   2.6          5    7.3   0.1    4.3  4  MIT           MIT (microtubule interacting and transport) dom
       0.12   13.0   0.0         28    5.5   0.0    3.6  3  TPR_16        Tetratricopeptide repeat
       0.14   12.1   2.4       0.81    9.7   0.2    2.6  2  PD40          WD40-like Beta Propeller Repeat


Domain annotation for each model (and alignments):
>> Peptidase_C2  Calpain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.38   3.4e+02     150     189 ..     285     326 ..     259     358 .. 0.69
   2 !  230.4   0.0   2.6e-71   2.3e-68       2     294 ..     653     958 ..     652     961 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.38
  Peptidase_C2 150 gstsealedftggvtesiel..elkeapkelfkilkkalerg 189
                   ++ +ea+edft  +++  e+  ++ ++++++ + l+++ +r 
    EFC39091.1 285 QKYVEAIEDFTKSIEHYQEIpqNSPDKKQQFDSFLETHSKRA 326
                   5789**********9999986522223333334444444433 PP

  == domain 2  score: 230.4 bits;  conditional E-value: 2.6e-71
  Peptidase_C2   2 eDpeFpaeesslfy..........kkskkkkkkveWkRpkeive..npkfivdgasrtdikqGelgdCwllaaiasltlkekllkrvvpkeqsfeek 86 
                    D+++p+ +ss+             +  +  +++ W+Rp++i+   +p+++vdg + +d+ qG+lg+Cw+l+a+a +++++ ++k+vv+++++  ++
    EFC39091.1 653 LDNSLPPITSSILGagtradfdlpPHIVNLDTDLVWLRPSQITGvtKPALFVDGSNYKDVIQGSLGNCWMLSAMAIVASHDFVMKKVVVESKT--NS 747
                   5666666666665556666655533444556699********8765899****************************************9965..44 PP

  Peptidase_C2  87 yaGifhfrfwrfgewvdvvvDDrlPt..vngklvfvksaeknefWsalleKAyAklhgsyealkggstsealedftggvtesielelkeapkelfki 181
                     G ++f +++ g+ +++++DD++P+  +++++vf +sa+ ne+W++lleKAyA l+g+y +lkgg++++al+d+tgg++ s++++  ++ +e+++ 
    EFC39091.1 748 AIGKYTFCLFKEGRNKEITIDDLIPCdvTTNSYVFSRSADPNELWVPLLEKAYAALYGNYFSLKGGHLKDALVDLTGGISFSYDID-PKKIEEVWQY 843
                   69************************87789*****************************************************86.555666**** PP

  Peptidase_C2 182 lkkalergslmgcsieassaeeleaklengLvkgHaYsvtaveevel...kkekvkLirlrnPWG.eveWkGawsdkskeWeevseeekekl.klkk 273
                   l+   +++s  ++   + +++e++a+  +g+++ HaY+++++ e+     ++++v+Li+++nPW+   eWkG+wsd +++W   s+e ++ + +  +
    EFC39091.1 844 LSCLPKQNSSSSSFKLMGARSETSASDYTGIINFHAYAILDAIEFPPhltNSQRVRLIKMKNPWAnGIEWKGEWSDYCPRW---SPELRKYVgNDFN 937
                   99888877777776666667778888899************999543444899************667*************...8999999954456 PP

  Peptidase_C2 274 kedgefwmsfedflknFtkle 294
                   ++dg f+ms+e f+ +++ +e
    EFC39091.1 938 SQDGIFYMSLEYFVVQWNMIE 958
                   79************9998876 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1       2.3   2.1e+03      11      30 ..      41      60 ..      39      60 .. 0.88
   2 ?   -0.6   0.1       1.5   1.4e+03      17      30 ..     189     202 ..     188     205 .. 0.87
   3 ?    1.9   0.0      0.24   2.2e+02       2      25 ..     228     251 ..     227     257 .. 0.87
   4 !   23.1   0.0   5.1e-08   4.6e-05       3      31 ..     273     301 ..     272     303 .. 0.94
   5 ?   -3.0   0.0       8.9     8e+03      21      30 ..     444     453 ..     444     453 .. 0.75
   6 !   14.5   0.0   2.6e-05     0.023       1      33 [.     468     500 ..     468     501 .. 0.91
   7 !   12.6   0.3    0.0001      0.09       2      34 .]     503     536 ..     502     536 .. 0.83
   8 ?   -0.1   0.0         1   9.2e+02       3      34 .]     539     570 ..     538     570 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 2.3
                HHHTT-HHHHHHHHHHHHHH CS
       TPR_1 11 yfklgkydeAleyyekALel 30
                +f++++y+ A+e  ek++++
  EFC39091.1 41 HFQKKEYKVAIEILEKCVQI 60
                79999**99***99999886 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.5
                 HHHHHHHHHHHHHH CS
       TPR_1  17 ydeAleyyekALel 30 
                 +++A+ ++++A++ 
  EFC39091.1 189 LEKAVIAFSEAIQM 202
                 589*********97 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.24
                 HHHHHHHHHHHHTT-HHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyye 25 
                 + + n+++ +   + y  A++++ 
  EFC39091.1 228 QYYLNRALSHNDINSYRPAEADFT 251
                 5799****************9997 PP

  == domain 4  score: 23.1 bits;  conditional E-value: 5.1e-08
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALeln 31 
                 a+ n+G  + +++ky eA+e++ k +e++
  EFC39091.1 273 AYHNRGISLSYMQKYVEAIEDFTKSIEHY 301
                 8*************************986 PP

  == domain 5  score: -3.0 bits;  conditional E-value: 8.9
                 HHHHHHHHHH CS
       TPR_1  21 leyyekALel 30 
                 l+ y++A++l
  EFC39091.1 444 LDLYNRAVKL 453
                 5779999886 PP

  == domain 6  score: 14.5 bits;  conditional E-value: 2.6e-05
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1   1 akalynlGnayfklgkydeAleyyekALelnPn 33 
                 a++++ +G++y k+++ ++A+ ++   + l  +
  EFC39091.1 468 ANIFFERGVLYNKMERVEQAIMDFTTSIDLHQQ 500
                 678999********************9999765 PP

  == domain 7  score: 12.6 bits;  conditional E-value: 0.0001
                 HHHHHHHHHHH.HTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   2 kalynlGnayf.klgkydeAleyyekALelnPnn 34 
                 +a++n++ +y+ k  +   A+++ ek++e++P++
  EFC39091.1 503 EAYFNRAILYYtKSRNTILAIKDLEKVIEIDPKD 536
                 6888888887636677889*************86 PP

  == domain 8  score: -0.1 bits;  conditional E-value: 1
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALelnPnn 34 
                 al  l++++ ++g+ +e  +  ++ Le +Pnn
  EFC39091.1 539 ALIELAVLLASNGQVEEGTKRLNQTLECDPNN 570
                 67789999999999999888888889999987 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0      0.18   1.6e+02      11      30 ..      41      60 ..      38      60 .. 0.91
   2 ?    0.1   0.1       1.3   1.2e+03      17      31 ..     189     203 ..     188     205 .. 0.88
   3 !   18.6   0.0   1.5e-06    0.0014       3      31 ..     273     301 ..     271     304 .. 0.93
   4 ?   -0.3   0.0       1.7   1.5e+03       2      30 ..     469     497 ..     468     500 .. 0.83
   5 !   11.6   0.0   0.00026      0.23       2      34 .]     503     536 ..     502     536 .. 0.93
   6 ?    6.7   0.0      0.01       9.1       3      34 .]     539     570 ..     537     570 .. 0.96

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.18
       TPR_2 11 yyklgdyeeAleafekAlel 30
                ++++++y+ A+e +ek++++
  EFC39091.1 41 HFQKKEYKVAIEILEKCVQI 60
                899*************9985 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 1.3
       TPR_2  17 yeeAleafekAleld 31 
                 +e+A+ af +A++ +
  EFC39091.1 189 LEKAVIAFSEAIQMA 203
                 589*********975 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 1.5e-06
       TPR_2   3 alynlGlayyklgdyeeAleafekAleld 31 
                 a++n+G ++ ++++y eA+e+f k++e++
  EFC39091.1 273 AYHNRGISLSYMQKYVEAIEDFTKSIEHY 301
                 8*************************987 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 1.7
       TPR_2   2 ealynlGlayyklgdyeeAleafekAlel 30 
                  + +++G +y k+ + e+A+ +f  ++ l
  EFC39091.1 469 NIFFERGVLYNKMERVEQAIMDFTTSIDL 497
                 67899**************9777777665 PP

  == domain 5  score: 11.6 bits;  conditional E-value: 0.00026
       TPR_2   2 ealynlGlayyklgdy.eeAleafekAleldPnn 34 
                 ea++n++ +yy + +    A++++ek++e+dP++
  EFC39091.1 503 EAYFNRAILYYTKSRNtILAIKDLEKVIEIDPKD 536
                 79********9998888***************86 PP

  == domain 6  score: 6.7 bits;  conditional E-value: 0.01
       TPR_2   3 alynlGlayyklgdyeeAleafekAleldPnn 34 
                 al +l+ +++ +g+ ee  + +++ le dPnn
  EFC39091.1 539 ALIELAVLLASNGQVEEGTKRLNQTLECDPNN 570
                 7999**************************98 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0    0.0016       1.4      11      31 ..      41      61 ..      38      64 .. 0.89
   2 ?   -0.2   0.2       1.7   1.5e+03      17      31 ..     189     203 ..     187     205 .. 0.89
   3 ?    2.7   0.0       0.2   1.8e+02       2      30 ..     228     256 ..     227     260 .. 0.91
   4 ?    5.5   0.0     0.026        23       3      29 ..     273     299 ..     272     300 .. 0.96
   5 ?    6.7   0.0      0.01       9.4       2      30 ..     469     497 ..     468     500 .. 0.88
   6 !   16.2   0.1   9.5e-06    0.0086       2      34 .]     503     536 ..     502     536 .. 0.91

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0016
                HHHTT-HHHHHHHHHHHHHHH CS
       TPR_8 11 ylklgdyeeAkeyyekaleld 31
                ++++++y+ A+e +ek++++ 
  EFC39091.1 41 HFQKKEYKVAIEILEKCVQIP 61
                789***************985 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.7
                 HHHHHHHHHHHHHHH CS
       TPR_8  17 yeeAkeyyekaleld 31 
                 +e+A+ ++ +a++++
  EFC39091.1 189 LEKAVIAFSEAIQMA 203
                 69**********997 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.2
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekalel 30 
                 ++y+n ++ + + + y  A++ +  +++l
  EFC39091.1 228 QYYLNRALSHNDINSYRPAEADFTSYISL 256
                 79*********************999988 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.026
                 HHHHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekale 29 
                 ay+n g  ++ +++y eA+e + k +e
  EFC39091.1 273 AYHNRGISLSYMQKYVEAIEDFTKSIE 299
                 79**********************997 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.01
                 CHHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   2 eayynlgsiylklgdyeeAkeyyekalel 30 
                  + +  g +y k+++ e+A+  +   ++l
  EFC39091.1 469 NIFFERGVLYNKMERVEQAIMDFTTSIDL 497
                 577899***************99988876 PP

  == domain 6  score: 16.2 bits;  conditional E-value: 9.5e-06
                 CHHHHHH.HHHHHTT-HHHHHHHHHHHHHHHHH. CS
       TPR_8   2 eayynlg.siylklgdyeeAkeyyekaleldpdn 34 
                 eay+n + + y k  +   A++ +ek++e+dp++
  EFC39091.1 503 EAYFNRAiLYYTKSRNTILAIKDLEKVIEIDPKD 536
                 89*****5555*********************96 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0      0.52   4.7e+02      14      32 ..      42      60 ..      38      61 .. 0.60
   2 !   14.7   0.0   3.1e-05     0.028       3      36 ..     271     304 ..     269     311 .. 0.88
   3 ?    2.1   0.0      0.26   2.3e+02      10      73 ..     431     452 ..     404     455 .. 0.64
   4 !   10.0   0.0    0.0009       0.8      10      76 ..     431     499 ..     423     500 .. 0.79
   5 !   12.8   0.0   0.00013      0.11       3      76 ..     468     534 ..     466     535 .. 0.83
   6 ?    2.4   0.0      0.21   1.9e+02       4      31 ..     538     565 ..     536     578 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.52
      TPR_12 14 rrlgrydeAlellekalei 32
                ++ ++y  A+e+lek+++i
  EFC39091.1 42 FQKKEYKVAIEILEKCVQI 60
                4555666666666666554 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 3.1e-05
      TPR_12   3 atalnnlaavlrrlgrydeAlellekaleiarrl 36 
                 ++a++n++  l ++++y eA+e + k++e ++++
  EFC39091.1 271 MIAYHNRGISLSYMQKYVEAIEDFTKSIEHYQEI 304
                 689999************************9998 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.26
      TPR_12  10 aavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeala 73 
                 a+  +  g                                          + ee l+l+++a++
  EFC39091.1 431 ALSKTGTG------------------------------------------QNEEILDLYNRAVK 452
                 33334445..........................................55555555555544 PP

  == domain 4  score: 10.0 bits;  conditional E-value: 0.0009
      TPR_12  10 aavlrrlgrydeAlellekaleia..rrllGpdhpltattlrnLgrlyralgryeeAlelleealaiae 76 
                 a+  +  g+ +e l+l+++a+ +   +++     ++ a++ +  g ly +++r e+A+  ++ ++++ +
  EFC39091.1 431 ALSKTGTGQNEEILDLYNRAVKLLdvESSKKVSGEQKANIFFERGVLYNKMERVEQAIMDFTTSIDLHQ 499
                 666677899999999999999998633335555699999999999999999999999999998888765 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 0.00013
      TPR_12   3 atalnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyr.algryeeAlelleealaiae 76 
                 a++  ++++++++++r ++A+  + ++++++++ l        ++++n ++ly+ ++ ++  A++ le++++i++
  EFC39091.1 468 ANIFFERGVLYNKMERVEQAIMDFTTSIDLHQQFL--------EAYFNRAILYYtKSRNTILAIKDLEKVIEIDP 534
                 56666799***********************9994........47888888876477888888888888888865 PP

  == domain 6  score: 2.4 bits;  conditional E-value: 0.21
      TPR_12   4 talnnlaavlrrlgrydeAlellekale 31 
                 tal +la++l+  g+ +e  + l++ le
  EFC39091.1 538 TALIELAVLLASNGQVEEGTKRLNQTLE 565
                 56778******************99998 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0       1.5   1.3e+03      15      34 .]     273     292 ..     270     292 .. 0.90
   2 ?    0.2   0.0       1.4   1.2e+03      13      33 ..     468     488 ..     466     489 .. 0.89
   3 ?    6.9   0.0      0.01         9       2      26 ..     491     515 ..     490     524 .. 0.80
   4 !   19.7   0.0   8.3e-07   0.00074       2      30 ..     526     554 ..     525     557 .. 0.93
   5 ?    2.5   0.1      0.26   2.3e+02       4      16 ..     562     574 ..     560     577 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 1.5
      TPR_17  15 aynnLAelllknGdlmtArq 34 
                 ay+n++  l+   ++ +A++
  EFC39091.1 273 AYHNRGISLSYMQKYVEAIE 292
                 8*********9999999985 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 1.4
      TPR_17  13 adaynnLAelllknGdlmtAr 33 
                 a+ ++++++l+ k  + ++A+
  EFC39091.1 468 ANIFFERGVLYNKMERVEQAI 488
                 7899*********99999997 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.01
      TPR_17   2 ylkaleldPnnadaynnLAelllkn 26 
                 ++ +++l+    +ay+n+A l++ +
  EFC39091.1 491 FTTSIDLHQQFLEAYFNRAILYYTK 515
                 6789999999***********9843 PP

  == domain 4  score: 19.7 bits;  conditional E-value: 8.3e-07
      TPR_17   2 ylkaleldPnnadaynnLAelllknGdlm 30 
                 ++k++e+dP++  a+ +LA+ll++nG+ +
  EFC39091.1 526 LEKVIEIDPKDTTALIELAVLLASNGQVE 554
                 59************************976 PP

  == domain 5  score: 2.5 bits;  conditional E-value: 0.26
      TPR_17   4 kaleldPnnaday 16 
                 + le+dPnn  a+
  EFC39091.1 562 QTLECDPNNETAH 574
                 679******6665 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       6.6   5.9e+03       5      17 ..      42      54 ..      40      60 .. 0.68
   2 ?   -1.4   0.0       2.1   1.9e+03       9      18 ..     293     302 ..     284     303 .. 0.61
   3 ?   -0.1   0.0      0.88   7.9e+02       8      23 ..     438     453 ..     437     453 .. 0.91
   4 !   12.2   0.0   0.00012      0.11       3      40 ..     477     514 ..     468     516 .. 0.93
   5 !   11.9   0.0   0.00015      0.14      13      42 .]     522     551 ..     521     551 .. 0.96
   6 ?    5.6   0.0     0.014        13       5      31 ..     548     574 ..     546     577 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 6.6
      TPR_11  5 yeqGkyeeAieaY 17
                +++ +y+ Aie +
  EFC39091.1 42 FQKKEYKVAIEIL 54
                7777888777755 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.1
      TPR_11   9 kyeeAieaYk 18 
                 +++++ie+Y+
  EFC39091.1 293 DFTKSIEHYQ 302
                 4566666666 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.88
      TPR_11   8 GkyeeAieaYkkAlkl 23 
                 G++ee +  Y++A+kl
  EFC39091.1 438 GQNEEILDLYNRAVKL 453
                 89999999******97 PP

  == domain 4  score: 12.2 bits;  conditional E-value: 0.00012
      TPR_11   3 ayyeqGkyeeAieaYkkAlkldPdnaeayynLGlayyk 40 
                 +y +  + e+Ai ++ + ++l +++ eay+n++ +yy 
  EFC39091.1 477 LYNKMERVEQAIMDFTTSIDLHQQFLEAYFNRAILYYT 514
                 5888999*****************************97 PP

  == domain 5  score: 11.9 bits;  conditional E-value: 0.00015
      TPR_11  13 AieaYkkAlkldPdnaeayynLGlayykqG 42 
                 Ai++++k +++dP++ +a+ +L+++++ +G
  EFC39091.1 522 AIKDLEKVIEIDPKDTTALIELAVLLASNG 551
                 9***********************999887 PP

  == domain 6  score: 5.6 bits;  conditional E-value: 0.014
      TPR_11   5 yeqGkyeeAieaYkkAlkldPdnaeay 31 
                  + G+ ee  +++++ l+ dP+n +a+
  EFC39091.1 548 ASNGQVEEGTKRLNQTLECDPNNETAH 574
                 6789**********************9 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       3.4     3e+03      30      58 ..     228     256 ..     222     265 .. 0.81
   2 !    9.4   0.0    0.0013       1.1      30      58 ..     469     497 ..     439     511 .. 0.86
   3 !   15.8   0.0   1.2e-05     0.011      13      67 ..     521     575 ..     509     581 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 3.4
       TPR_9  30 eerrdRGlllaqlGclsaAladLeaylal 58 
                 + ++ R+l +   + ++ A ad+  y++l
  EFC39091.1 228 QYYLNRALSHNDINSYRPAEADFTSYISL 256
                 55778999999999999********9976 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0013
       TPR_9  30 eerrdRGlllaqlGclsaAladLeaylal 58 
                    ++RG+l+ +++++++A++d+ + ++l
  EFC39091.1 469 NIFFERGVLYNKMERVEQAIMDFTTSIDL 497
                 5678*******************998776 PP

  == domain 3  score: 15.8 bits;  conditional E-value: 1.2e-05
       TPR_9  13 ralavverllllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdaea 67 
                  a++ +e ++ ++P+d   + + ++lla  G+++++ + L++ l+ +p++++a+ 
  EFC39091.1 521 LAIKDLEKVIEIDPKDTTALIELAVLLASNGQVEEGTKRLNQTLECDPNNETAHK 575
                 689999*******************************************999975 PP

>> Calpain_III  Calpain large subunit, domain III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       1.6   1.4e+03      68     113 ..      18      61 ..       5      74 .. 0.74
   2 !   25.9   0.0   1.1e-08   9.9e-06      39     140 ..    1003    1105 ..     968    1106 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.6
  Calpain_III  68 favykveeeeenrklrkeffaknqevarsstfinsrevvkrfklpp 113
                   ++y v  ++++++ + +++++++e+ ++++++ + e+ +++   p
   EFC39091.1  18 DSIYFV--SSRDKQHTLKQLQTSTEHFQKKEYKVAIEILEKCVQIP 61 
                  567775..55566666677788899999999999999998874444 PP

  == domain 2  score: 25.9 bits;  conditional E-value: 1.1e-08
  Calpain_III   39 ekkctvlvslmqknrrkerkkgeelltigfavykveeeeenrklrkeffaknqevarsstfinsrevvkrfklppGeYvivPs....tf.epneeg 129 
                    +++++++sl q ++r  ++++++   i++++ +v++ +++r ++ +    ++++  + +++  re+v  + lp G+Yv +P+    t  +  e g
   EFC39091.1 1003 YENNRLVISLTQLDTRYVHDSKDDDSCIAVHLIRVDQPSPSRLIKIN----KKDIIVQGDYKYDREIVVDCCLPSGSYVAIPHeyftTNcKNTELG 1094
                   357899*******999988898999999******8776666666665....3579999************************7322232245567* PP

  Calpain_III  130 eFlLrvFsekk 140 
                    +++r+ se+k
   EFC39091.1 1095 AYTIRILSESK 1105
                   ********987 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       7.5   6.7e+03       4      18 ..      44      58 ..      42      62 .. 0.77
   2 ?   -1.5   0.0       4.3   3.9e+03       4      21 ..     284     301 ..     275     315 .. 0.64
   3 ?   -0.6   0.0       2.2     2e+03      20      39 ..     418     436 ..     405     439 .. 0.77
   4 ?   -2.0   0.0       6.1   5.5e+03       4      38 ..     481     515 ..     480     519 .. 0.83
   5 !   23.2   0.0     8e-08   7.2e-05      10      62 ..     522     574 ..     515     580 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 7.5
      TPR_19  4 egdyaeAlalleqal 18
                 + y  A+++le+  
  EFC39091.1 44 KKEYKVAIEILEKCV 58
                567999999999865 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 4.3
      TPR_19   4 egdyaeAlalleqalqed 21 
                 +++y eA++ +++ ++++
  EFC39091.1 284 MQKYVEAIEDFTKSIEHY 301
                 677777777777655332 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 2.2
      TPR_19  20 edpknaearllLAeallalg 39 
                 +  +n    l+LA+al ++g
  EFC39091.1 418 Q-GNNYKTSLDLAKALSKTG 436
                 3.6899999*******9998 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 6.1
      TPR_19   4 egdyaeAlalleqalqedpknaearllLAeallal 38 
                 +++ ++A+  ++  ++   + +ea  + A++++  
  EFC39091.1 481 MERVEQAIMDFTTSIDLHQQFLEAYFNRAILYYTK 515
                 56778899899999999999999999999999865 PP

  == domain 5  score: 23.2 bits;  conditional E-value: 8e-08
      TPR_19  10 AlalleqalqedpknaearllLAeallalgqldeAealLdalpeedpddarya 62 
                 A++ le++++ dpk+  a++ LA +l ++gq++e  + L++ +e dp+++ ++
  EFC39091.1 522 AIKDLEKVIEIDPKDTTALIELAVLLASNGQVEEGTKRLNQTLECDPNNETAH 574
                 8999********************************************87776 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0      0.27   2.4e+02       5      30 ..     426     453 ..     423     458 .. 0.83
   2 !   11.0   0.0    0.0007      0.63       3      44 .]     504     546 ..     502     546 .. 0.82
   3 ?    6.4   0.0     0.021        19       6      41 ..     542     577 ..     540     578 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.27
      TPR_14   5 lalaealla..lGdpdeAiallrralal 30 
                 l+la+al     G+ +e ++l++ra++l
  EFC39091.1 426 LDLAKALSKtgTGQNEEILDLYNRAVKL 453
                 6899999772257************985 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.0007
      TPR_14   3 allalaea.llalGdpdeAiallrralalaPddaeawlllaql 44 
                 a+  +a + +  ++++  Ai+ l+++++ +P+d +a+++la l
  EFC39091.1 504 AYFNRAILyYTKSRNTILAIKDLEKVIEIDPKDTTALIELAVL 546
                 666566651567899999**********************975 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.021
      TPR_14   6 alaeallalGdpdeAiallrralalaPddaeawlll 41 
                 +la +l+ +G+ +e  + l++ l+ +P++++a+ +l
  EFC39091.1 542 ELAVLLASNGQVEEGTKRLNQTLECDPNNETAHKYL 577
                 689999**************************9886 PP

>> TPR_20  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       4.2   3.8e+03      24      50 ..      33      59 ..      25      64 .. 0.81
   2 !   18.7   0.1   1.9e-06    0.0017       7      56 ..     522     571 ..     516     582 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 4.2
      TPR_20 24 arldlAlallaagryeeAleqLleilk 50
                 +l+ ++  +++++y+ A+e L + ++
  EFC39091.1 33 KQLQTSTEHFQKKEYKVAIEILEKCVQ 59
                689999999**********99977776 PP

  == domain 2  score: 18.7 bits;  conditional E-value: 1.9e-06
      TPR_20   7 elaeleaalaanpddldarldlAlallaagryeeAleqLleilkrdrkwe 56 
                  +++le+ ++ +p+d  a ++lA +l+++g++ee  ++L + l+ d + e
  EFC39091.1 522 AIKDLEKVIEIDPKDTTALIELAVLLASNGQVEEGTKRLNQTLECDPNNE 571
                 6899**************************************99887763 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       2.9   2.6e+03      12      28 ..      43      59 ..      35      61 .. 0.83
   2 ?    1.1   0.0      0.88   7.9e+02       4      30 ..     275     301 ..     273     310 .. 0.51
   3 ?   -1.2   0.0       4.6   4.1e+03       6      28 ..     428     452 ..     425     453 .. 0.77
   4 ?   -0.6   0.0         3   2.7e+03       4      23 ..     472     491 ..     470     497 .. 0.85
   5 !    8.5   0.0    0.0039       3.5       1      32 [.     503     535 ..     503     536 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 2.9
                HHHHHHHHHHHHHHHHH CS
       TPR_6 12 klgdtdkAlealerlik 28
                + +++  A+e+le++++
  EFC39091.1 43 QKKEYKVAIEILEKCVQ 59
                4458999*******987 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.88
                 HHHHHHHHHHHHHHHHHHHHHHHHHH- CS
       TPR_6   4 yklalsyrklgdtdkAlealerlikeY 30 
                  +++ s+  ++++ +A+e + + i+ Y
  EFC39091.1 275 HNRGISLSYMQKYVEAIEDFTKSIEHY 301
                 556666666445555555555444433 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 4.6
                 HHHHHHH.H.HHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrk.l.gdtdkAlealerlik 28 
                 la+++ k + g+ ++ l++++r +k
  EFC39091.1 428 LAKALSKtGtGQNEEILDLYNRAVK 452
                 66666664457999******99986 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 3
                 HHHHHHHHHHHHHHHHHHHH CS
       TPR_6   4 yklalsyrklgdtdkAleal 23 
                 + ++ +y k+ + ++A+  +
  EFC39091.1 472 FERGVLYNKMERVEQAIMDF 491
                 8899*****88*****9766 PP

  == domain 5  score: 8.5 bits;  conditional E-value: 0.0039
                 HHHHHHHHHHH.HHHHHHHHHHHHHHHHHH-TT CS
       TPR_6   1 dAlyklalsyr.klgdtdkAlealerlikeYPd 32 
                 +A++++a +y+ k  +t  A++ le++i+  P+
  EFC39091.1 503 EAYFNRAILYYtKSRNTILAIKDLEKVIEIDPK 535
                 79*********5567**************9997 PP

>> SHNi-TPR  SHNi-TPR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       3.5   3.2e+03      22      34 ..      45      57 ..      45      59 .. 0.84
   2 ?    5.8   0.0      0.01       9.4      16      33 ..     286     303 ..     285     306 .. 0.87
   3 !    6.4   0.0    0.0069       6.2      18      36 ..     485     503 ..     481     504 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 3.5
    SHNi-TPR 22 eDlrkaLeLreql 34
                ++++ a+e+ e++
  EFC39091.1 45 KEYKVAIEILEKC 57
                6899999999998 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.01
    SHNi-TPR  16 nFpqAveDlrkaLeLreq 33 
                 ++ +A+eD++k++e +++
  EFC39091.1 286 KYVEAIEDFTKSIEHYQE 303
                 6889*********97776 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0069
    SHNi-TPR  18 pqAveDlrkaLeLreqllp 36 
                 +qA+ D++++++L +q l+
  EFC39091.1 485 EQAIMDFTTSIDLHQQFLE 503
                 8**************9887 PP

>> DUF4437  Domain of unknown function (DUF4437)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.53   4.7e+02      44      61 ..     670     687 ..     661     692 .. 0.85
   2 ?   -4.0   0.0       7.2   6.4e+03       7      37 ..     838     869 ..     837     871 .. 0.75
   3 ?    0.8   0.0      0.24   2.2e+02      45      67 ..     934     956 ..     927     962 .. 0.88
   4 !    9.1   0.0    0.0007      0.63      33      89 ..    1024    1081 ..    1015    1096 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.53
                 -TT-EE--BEESS-EEEE CS
     DUF4437  44 kkgFespphihnvdyrgv 61 
                 + +F+ pphi n d+ +v
  EFC39091.1 670 RADFDLPPHIVNLDTDLV 687
                 689**********99876 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 7.2
                 -EEEE--TTS-T.TS--EEEEEEEE-.TTS-E CS
     DUF4437   7 dvewgalnplrg.dkspgarrLwgdrtedgas 37 
                 +++w++l  l+  + s  + +L+g r e+ as
  EFC39091.1 838 EEVWQYLSCLPKqNSSSSSFKLMGARSETSAS 869
                 57899999887515667788999999877776 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.24
                 TT-EE--BEESS-EEEEEEESEE CS
     DUF4437  45 kgFespphihnvdyrgvVikGal 67 
                 ++F+s  +i+ ++++++V++  +
  EFC39091.1 934 NDFNSQDGIFYMSLEYFVVQWNM 956
                 79*****************9776 PP

  == domain 4  score: 9.1 bits;  conditional E-value: 0.0007
                  TTS-EEEEEEE.-TT-EE--BEESS-EEEEEEESEEEETTEE.....E-TTEEEEE-T CS
     DUF4437   33 edgasgflvkf.kkgFespphihnvdyrgvVikGalhnddekaekmWlpkgsywtqPa 89  
                  +d+ s + v++ + +  sp+ + +++ + ++++G  ++d e   +  lp gsy+ +P 
  EFC39091.1 1024 KDDDSCIAVHLiRVDQPSPSRLIKINKKDIIVQGDYKYDREIVVDCCLPSGSYVAIPH 1081
                  666777777653667889**************************************96 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.39   3.5e+02      12      31 ..      41      60 ..      39      60 .. 0.90
   2 ?    7.8   0.0    0.0034       3.1       4      35 ..     273     304 ..     271     310 .. 0.90
   3 ?   -1.7   0.0       3.3     3e+03       9      34 ..     475     500 ..     474     505 .. 0.89
   4 ?   -1.5   0.0         3   2.6e+03      11      31 ..     512     532 ..     507     532 .. 0.82
   5 ?   -0.7   0.0       1.6   1.5e+03       3      22 ..     538     557 ..     537     566 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.39
      TPR_10 12 lrqrgrydeAealleealai 31
                ++q ++y+ A ++le++++i
  EFC39091.1 41 HFQKKEYKVAIEILEKCVQI 60
                5788999***********97 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0034
      TPR_10   4 slnNLanalrqrgrydeAealleealairrrl 35 
                 +++N ++ l+ +++y eA +++ ++++ ++++
  EFC39091.1 273 AYHNRGISLSYMQKYVEAIEDFTKSIEHYQEI 304
                 79***********************9988876 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 3.3
      TPR_10   9 analrqrgrydeAealleealairrr 34 
                 ++++ ++ r ++A  ++  +++++++
  EFC39091.1 475 GVLYNKMERVEQAIMDFTTSIDLHQQ 500
                 78999********9999999999987 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 3
      TPR_10  11 alrqrgrydeAealleealai 31 
                 ++++ ++   A ++le++++i
  EFC39091.1 512 YYTKSRNTILAIKDLEKVIEI 532
                 45899999999*******987 PP

  == domain 5  score: -0.7 bits;  conditional E-value: 1.6
      TPR_10   3 sslnNLanalrqrgrydeAe 22 
                 ++l  La++l + g+ +e  
  EFC39091.1 538 TALIELAVLLASNGQVEEGT 557
                 68999**********99855 PP

>> CNOT11  CCR4-NOT transcription complex subunit 11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.1     0.003       2.7       7      81 ..     279     355 ..     265     366 .. 0.65
   2 ?    1.3   0.0       0.4   3.6e+02      33      66 ..     476     513 ..     450     527 .. 0.77
   3 ?   -1.9   0.0       3.9   3.5e+03      20      63 ..     839     882 ..     833     903 .. 0.65

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.003
      CNOT11   7 iAielLlkllks.....seaneyldvlvkldvtlhslevvnrltse..........aelpkefvhkyisnciksceeakdkeaqerlvrl 81 
                 i  ++++k++++     +++++y ++ ++ +              +           + + + +h +i   ++ c++ +dk++ ++ ++l
  EFC39091.1 279 ISLSYMQKYVEAiedftKSIEHYQEIPQNSPD-------------KkqqfdsfletHSKRAKAIHRFIVDHVHDCRDNNDKAMMDKILKL 355
                 44444444444433333333334444444444.............04444444444668899**********************999987 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.4
      CNOT11  33 vtlhslevvnr.lts...eaelpkefvhkyisnciksc 66 
                 v  + +e v++ ++    + +l+++f+++y ++ i   
  EFC39091.1 476 VLYNKMERVEQaIMDfttSIDLHQQFLEAYFNRAILYY 513
                 55677888887554454469**********99988665 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 3.9
      CNOT11  20 eaneyldvlvkldvtlhslevvnrltseaelpkefvhkyisnci 63 
                 e+ +yl++l k +++ +s+ ++   +++++   + + ++ +  i
  EFC39091.1 839 EVWQYLSCLPKQNSSSSSFKLMGARSETSASDYTGIINFHAYAI 882
                 5778**************99998877755555555555554444 PP

>> MIT  MIT (microtubule interacting and transport) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       5.1   4.6e+03      19      39 ..      46      59 ..      35      64 .. 0.67
   2 ?    7.3   0.1    0.0056         5      18      64 ..     285     330 ..     272     331 .. 0.88
   3 ?    1.5   0.0      0.37   3.3e+02      24      44 ..     402     423 ..     402     437 .. 0.78
   4 ?   -0.6   0.1       1.6   1.5e+03      18      35 ..     438     455 ..     427     487 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 5.1
         MIT 19 nyeeAlelYkealelLlqalk 39
                +       Yk a+e+L + ++
  EFC39091.1 46 E-------YKVAIEILEKCVQ 59
                4.......5566666655554 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0056
         MIT  18 gnyeeAlelYkealelLlqalkekneerrellrekieeYleRaeeLk 64 
                 ++y eA+e +++++e+ +++ + +++ +++ + + +e+  +Ra+ ++
  EFC39091.1 285 QKYVEAIEDFTKSIEHYQEIPQ-NSPDKKQQFDSFLETHSKRAKAIH 330
                 89*******************9.67799***************9886 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.37
         MIT  24 lelYkealelLlqalke.knee 44 
                 +elY++++ +L + +k+ +n +
  EFC39091.1 402 FELYSQSIPHLRECIKQgNNYK 423
                 69**************646543 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 1.6
         MIT  18 gnyeeAlelYkealelLl 35 
                 g+ ee l+lY  a++lL 
  EFC39091.1 438 GQNEEILDLYNRAVKLLD 455
                 666777999999999996 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       3.6   3.2e+03      34      60 ..     227     253 ..     221     259 .. 0.81
   2 ?    2.5   0.0      0.27   2.4e+02       9      49 ..     480     517 ..     472     519 .. 0.88
   3 ?    5.5   0.0     0.031        28      16      66 ..     522     569 ..     521     571 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 3.6
      TPR_16  34 aeAllllgdaalrqgrlaeAaalyraa 60 
                 ++ +l++++++   + + +A+a + ++
  EFC39091.1 227 PQYYLNRALSHNDINSYRPAEADFTSY 253
                 678888888888889999999888776 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.27
      TPR_16   9 ragdyddAaaaleaalkrdpssPdaaeAllllgdaalrqgr 49 
                 +  + ++A+  +++ ++++    +  eA+++++ +++ ++r
  EFC39091.1 480 KMERVEQAIMDFTTSIDLH---QQFLEAYFNRAILYYTKSR 517
                 6789999999*********...***************9887 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.031
      TPR_16  16 AaaaleaalkrdpssPdaaeAllllgdaalrqgrlaeAa.alyraalraapd 66 
                 A++ le +++ d   P +  Al +l+++++ +g ++e    l + + +++p+
  EFC39091.1 522 AIKDLEKVIEID---PKDTTALIELAVLLASNGQVEEGTkRLNQTL-ECDPN 569
                 899999******...********************99875555444.66666 PP

>> PD40  WD40-like Beta Propeller Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.2    0.0009      0.81      17      30 ..      14      27 ..      12      32 .. 0.90
   2 ?    1.4   0.2      0.38   3.4e+02      10      18 ..     918     926 ..     911     926 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.0009
                -TTSSEEEEEEECT CS
        PD40 17 SPDGkrlaFsSdRg 30
                S DG +++F+S+R+
  EFC39091.1 14 SDDGDSIYFVSSRD 27
                89***********8 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.38
                 .EEEEEE-T CS
        PD40  10 negaPsfSP 18 
                  +++P++SP
  EFC39091.1 918 SDYCPRWSP 926
                 589*****9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1113 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       724  (0.0403815); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.83u 0.33s 00:00:01.15 Elapsed: 00:00:00.54
# Mc/sec: 6229.14
//
Query:       EFC39092.1  [L=408]
Description: hypothetical protein NAEGRDRAFT_81416 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-25   90.3   0.0    3.3e-25   89.2   0.0    1.6  1  DUF2263   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF2263  Uncharacterized protein conserved in bacteria (DUF2263)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   89.2   0.0   1.9e-29   3.3e-25      11     145 ..     106     249 ..      88     250 .. 0.89

  Alignments for each domain:
  == domain 1  score: 89.2 bits;  conditional E-value: 1.9e-29
                 TEEE-TTS-EEE-HHH.HHHHHHT-EEE-H...........HHHHHHEEES--HHHHHHHHHHH-.......SS--EEEEE--SSSTTTTGGGT--SHH CS
     DUF2263  11 geylnskgekvdlrea.veaavkgtklysp.kkaastseeeeeetkievteestleaarrlvkee.......gekvavLNfASaknpGGGflnGakAQE 100
                 ge+  +k+++++l+e+ + +a  ++k+y++   + s++  + e+t++ v++ ++++ a ++++         +e+vavLN+A+ + pGGG+++G  AQE
  EFC39092.1 106 GEFSLDKKKRIELSEKiLVNASVKSKYYKNeGLEVSEKVGDLEKTQVLVINGDCIDIAFHIQDLLikegkfgKERVAVLNMANPNTPGGGYKGGCGAQE 204
                 6667789999****998667777888997754456677778899*************999876557779***9************************** PP

                 HHHHHHBSHHHHHTT-HHHHHHHHHH--TT--S-EEEEEEEEEEE CS
     DUF2263 101 EsLarsSaLyasllkaeefYeahrakrsplysdamiYSpeVpvfr 145
                 E+L r+S+Ly++l +  +  ++ r+ ++p+  ++ +YSp+V++fr
  EFC39092.1 205 ENLHRRSNLYQCLDNYVDKIDKTRTWNYPIGYESGVYSPDVTFFR 249
                 ***************99999************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (408 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2567.41
//
Query:       EFC39093.1  [L=393]
Description: ERG4/ERG24 ergosterol biosynthesis protein family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.8e-87  293.9  19.5    1.9e-87  293.8  19.5    1.0  1  ERG4_ERG24  Ergosterol biosynthesis ERG4/ERG24 family
     0.0003   20.4   0.2     0.0013   18.3   0.2    2.1  1  DUF1295     Protein of unknown function (DUF1295)


Domain annotation for each model (and alignments):
>> ERG4_ERG24  Ergosterol biosynthesis ERG4/ERG24 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  293.8  19.5   2.2e-91   1.9e-87      44     432 .]       6     393 .]       1     393 [] 0.91

  Alignments for each domain:
  == domain 1  score: 293.8 bits;  conditional E-value: 2.2e-91
  ERG4_ERG24  44 ldlaelkneikeldllvfegaiwerklftvfllfyvlqavlylllpGkvveGleLsngkkLkYkinalaslllvlaillvlqvtelf.....eltvlid 137
                 +++a + n ++ l+ l   + +++ +   +f++ +++ +v  l+lpGk+v+G++L++g+++ Ykin+l  +ll +     l ++++       + ++  
  EFC39093.1   6 VTIAYFNNGLDVLSMLSRWQ-VPSSESVMIFMSSVLFCIVATLVLPGKMVQGVPLKDGSRITYKINGLSVVLLGTLFYGLLCYFNFQignelIYSLVCK 103
                 67777888888766555444.799**********************************************88888888888888754222113456789 PP

  ERG4_ERG24 138 nfvqlisvailfafalaivlYvrslkvkerkkdkqlaaggvsGnliYDffiGreLnPRlgslDlkmFlelRlgllllllinlaallkqyklygkvtdsl 236
                  f+ql++++++f+f+l+ +l +r +  +e +     ++     n+i +f+ G eLnP +  +++k+F+  R+++l++ ++nl+++ +q++ly + +++ 
  EFC39093.1 104 SFGQLLVTSLVFSFLLTSFLNLRCVLQPE-RS----NYVYPKWNIIMNFWCGVELNPHIFGFEIKQFS-YRPAFLMIGILNLSFAFEQFRLYQTLSQNF 196
                 9***********************99988.33....45666789**********************97.7***************************** PP

  ERG4_ERG24 237 llvllaqllYvfdgvkneeavlttmDittdgFGFmLaFgdlvlvPftYslqtlYLsvhPselgwstvlvailvvlligyyiFrsansqknnFRtnPedp 335
                 +   ++  lY++d+   ee+++ ++Di  ++FGFmL+Fgd  + Pf+++lq lYL+    + ++   +va  ++ ++gy iFr an+qk  FR+ P++ 
  EFC39093.1 197 ITFQIISFLYLIDCFVFEEGLIFMFDIIEENFGFMLVFGDYMWTPFIFTLQNLYLINDFNVNHFQ--TVANILIFIVGYIIFRGANNQKITFRQDPKQV 293
                 ********************************************************997777766..588888999*********************** PP

  ERG4_ERG24 336 klkl..lkyiqtktGskLlvsGWyglarkinYlgDwlqslswsLat.gfqsvlpyfyvlyFlvlLvhRelRDeekCkkkYGedweeYkkkvpykiipyv 431
                 +l l  +k+++t++  kLl+sG++g+arkinYlgD+l+++s s ++    +vlp+ y++y   lL+hR++RD+e+Ck+kYG+ w+eY+ kv++++ip++
  EFC39093.1 294 WLGLiePKVLETSRDRKLLISGFWGMARKINYLGDILVAISQSFPClQCGHVLPWMYPIYLTPLLLHRAMRDNERCKEKYGKFWDEYCSKVRWVMIPGI 392
                 *87767************************************999934679***********************************************9 PP

  ERG4_ERG24 432 y 432
                 y
  EFC39093.1 393 Y 393
                 8 PP

>> DUF1295  Protein of unknown function (DUF1295)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.2   1.4e-07    0.0013     121     223 ..     262     374 ..     230     384 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 1.4e-07
     DUF1295 121 dviglalwlvgivlealaDqQlsaf..............kkdpankgk.vldsGLwrysRHPNYfgealiWwglflialealeglealaiagpllltll 204
                  v+ + +++vg ++   a +Q+ +f              k   +++ + +l sG+w ++R  NY+g++l+ ++     l+ ++ l +   + p+ lt l
  EFC39093.1 262 TVANILIFIVGYIIFRGANNQKITFrqdpkqvwlgliepKVLETSRDRkLLISGFWGMARKINYLGDILVAISQSFPCLQCGHVLPW---MYPIYLTPL 357
                 3456789******************99999999999988766667766699*******************99988888888777644...458888888 PP

     DUF1295 205 lvfvsgipllEkkalkkyk 223
                 l++ + ++  E + ++ky+
  EFC39093.1 358 LLHRA-MRDNE-RCKEKYG 374
                 88877.66666.4444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       706  (0.0393775); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2345.77
//
Query:       EFC39094.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.047   13.8   2.7      0.087   13.0   0.1    2.4  2  PI3K_rbd        PI3-kinase family, ras-binding domain
      0.057   13.0   0.0      0.095   12.2   0.0    1.4  1  DAPG_hydrolase  DAPG hydrolase PhiG domain
      0.087   13.1   0.0       0.15   12.4   0.0    1.4  1  HTH_Tnp_1       Transposase


Domain annotation for each model (and alignments):
>> PI3K_rbd  PI3-kinase family, ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   1.5e-05     0.087      38      83 ..      63     115 ..      21     123 .. 0.78
   2 ?    0.3   0.5      0.12   7.4e+02      11      40 ..     161     190 ..     151     243 .. 0.58

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.5e-05
                 TS-HHHHHHHHHHC...HH----------....GEEEEETTCSEEE-SSS-GG CS
    PI3K_rbd  38 nstpesllaealrk...klsvldqedvtd....dyvLkvcGrdeyllgkhpLs 83 
                 +++ ++++  +l+k   +l+v +++dv +    +++L v+G +e l+ k  L 
  EFC39094.1  63 QQVKKQFISHLLAKgvvNLEVSNKNDVDSntldQFRLLVTGGKELLVDKKSLQ 115
                 3444555556666699999999999999999*9************99988775 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.12
                 TTSSTSEEEEEEECSS-SEEEEEEEETTS- CS
    PI3K_rbd  11 nklkknkllvsvllenkqqkvtlkvnpnst 40 
                 +k+ + kl ++ ++ ++  +  +++++n+ 
  EFC39094.1 161 KKHVEVKLRIQEKVGDQVLTCDISCKNNKK 190
                 344444444444444444444444444443 PP

>> DAPG_hydrolase  DAPG hydrolase PhiG domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   1.6e-05     0.095      77     125 ..     149     197 ..     136     234 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.6e-05
  DAPG_hydrolase  77 edrlsdeslsleerylgnthyvtEdvgeglekleirFvdpeelGldeek 125
                     +d++++e+++ ++++++   +++E+vg++++  +i+ ++ +++G+ ++ 
      EFC39094.1 149 SDYVERETIKIKKKHVEVKLRIQEKVGDQVLTCDISCKNNKKFGVISKM 197
                     6778999*************************************87655 PP

>> HTH_Tnp_1  Transposase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   2.5e-05      0.15       9      57 ..      63     111 ..      62     141 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.5e-05
   HTH_Tnp_1   9 defKariVreslepgksvsevArrhgvspnqLykWrrqyregeeaspae 57 
                 +++K++++   l  g+   ev  + +v+ n+L + r ++ +g e + ++
  EFC39094.1  63 QQVKKQFISHLLAKGVVNLEVSNKNDVDSNTLDQFRLLVTGGKELLVDK 111
                 589************************************9888888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       902  (0.0503096); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1422.35
//
Query:       EFC39095.1  [L=170]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.59   10.5  35.3       0.05   14.0  13.7    2.0  2  ESM4             Enhancer of split M4 family
        2.1    8.0  20.7        2.5    7.7  20.7    1.0  1  Sin3a_C          C-terminal domain of Sin3a protein


Domain annotation for each model (and alignments):
>> ESM4  Enhancer of split M4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5  14.0      0.02   1.7e+02      59     125 ..       4      72 ..       1      78 [. 0.73
   2 ?   14.0  13.7   5.6e-06      0.05       9      84 ..      85     161 ..      74     169 .. 0.66

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.02
        ESM4  59 nvdlentqqqqqqqqe.eldednssnaeLeqqlveeevek.saqscaacahgrncqhthhqlvssssee 125
                 n++ +++  q ++q++  +++ ++ n++L++ql +e  ek + ++ +++a+ +n+++++++ + ss+e+
  EFC39095.1   4 NKTAKSQTPQVKPQIQkIEKQHQQINNDLNKQLKKENSEKkKQHQTSSDAALKNQESKQVSSTGSSPEN 72 
                 555566555566666634455566789999999999999956889999999999999999777777665 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 5.6e-06
        ESM4   9 ksesntiaenkansek.kavrrlkkvlkpLrrllkkggkgrkt.eltlahpnnvdlentqqqqqqqqeeldednssna 84 
                 +s+ +  +e+k+n+++ k++ r++kv+k L+  +kk++k++k  +  l +++n++ e++ q+  +  +e +e+n++n 
  EFC39095.1  85 TSDLSPSSESKSNDKReKTMERIRKVVKQLKEDQKKEEKKSKVlKTPLIEEINESEEKECQS-SESSSEKKEENERND 161
                 55555555555554434***************999999999974444555666665554432.233337777787773 PP

>> Sin3a_C  C-terminal domain of Sin3a protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7  20.7   0.00028       2.5     113     267 ..      18     169 ..      14     170 .] 0.65

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00028
     Sin3a_C 113 iqalvkqlqtivsDekcqellelfekerskeettsqd..eisyrkkaekllkdenlfriewkseskkltiqlldkddetldddeveaeerwkeYvesYv 209
                 iq++ kq q+i +D  +++l +   +++++++t+s++  + +  k++ ++ +  +  + e+ ++++++t  l  + +++++d+  ++ er ++ v++  
  EFC39095.1  18 IQKIEKQHQQINND-LNKQLKKENSEKKKQHQTSSDAalKNQESKQVSSTGSSPENIKTEVTPSNNQATSDLSPSSESKSNDKREKTMERIRKVVKQLK 115
                 89999999999988.3333333333333344443333556677777888875556669999*******************999967899******9999 PP

     Sin3a_C 210 lveptegvereklkkvfLkRnlkaerkeeekkeeeeqekaekeeeaekeleveeklei 267
                  ++++e+ +++ lk ++++   ++e+ke ++ e+++++k+e+e   ++++e ++ +e+
  EFC39095.1 116 EDQKKEEKKSKVLKTPLIEEINESEEKECQSSESSSEKKEENE---RNDAE-ASTVEC 169
                 7777777777777777777666555554444444333333322...22222.345555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (170 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4655  (0.259635); expected 358.6 (0.02)
Passed bias filter:                      725  (0.0404373); expected 358.6 (0.02)
Passed Vit filter:                       217  (0.0121033); expected 17.9 (0.001)
Passed Fwd filter:                        81  (0.00451782); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.02u 0.36s 00:00:01.38 Elapsed: 00:00:00.53
# Mc/sec: 957.76
//
Query:       EFC39096.1  [L=1564]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.6e-47  158.1 226.4     0.0001   22.6  10.2   12.4 12  EGF_2            EGF-like domain
    0.00039   20.5   0.1       0.11   12.8   0.0    3.3  3  Bacteriocin_IId  Bacteriocin class IId cyclical uberolysin-li
     0.0024   18.2   0.3     0.0067   16.7   0.3    1.8  1  RGS              Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.013   15.8   0.5        3.9    7.9   0.2    3.1  2  DUF4413          Domain of unknown function (DUF4413)
       0.17   12.4   5.2        0.2   12.1   2.9    2.2  2  CelTOS           Cell-traversal protein for ookinetes and spo


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9  11.5     2e-07    0.0007       6      32 .]      99     124 ..      95     124 .. 0.92
   2 !   22.6  10.2   2.8e-08    0.0001       7      32 .]     141     165 ..     137     165 .. 0.93
   3 !   16.2  12.1   2.8e-06    0.0099       5      32 .]     184     210 ..     180     210 .. 0.87
   4 !   20.7  11.6   1.1e-07   0.00039       6      32 .]     228     253 ..     224     253 .. 0.89
   5 !   19.7  12.0   2.3e-07   0.00081       6      32 .]     271     296 ..     267     296 .. 0.90
   6 !   21.1  10.6   8.4e-08    0.0003       6      32 .]     314     339 ..     309     339 .. 0.92
   7 !   19.9  10.8     2e-07   0.00073       5      32 .]     360     386 ..     356     386 .. 0.90
   8 !   19.4  13.5   2.9e-07     0.001       5      32 .]     403     429 ..     399     429 .. 0.90
   9 !   20.5  10.9   1.3e-07   0.00045       7      32 .]     448     472 ..     444     472 .. 0.92
  10 !   21.7  10.3   5.3e-08   0.00019       6      32 .]     492     517 ..     488     517 .. 0.89
  11 !   18.7  12.3   4.5e-07    0.0016       6      32 .]     538     563 ..     534     563 .. 0.89
  12 !    7.8  12.5    0.0012       4.4       4      32 .]     576     606 ..     570     606 .. 0.87

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 2e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +++ +C+C++g++G++C
  EFC39096.1  99 SVCSGNGNCTSKN-NCECNDGFSGNKC 124
                 57*******9888.8************ PP

  == domain 2  score: 22.6 bits;  conditional E-value: 2.8e-08
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+ghG C +++ +C Cdsgy+G++C
  EFC39096.1 141 VCSGHGNCSSKN-NCLCDSGYSGNKC 165
                 6*******9899.8************ PP

  == domain 3  score: 16.2 bits;  conditional E-value: 2.8e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G C +++ +C+C++gy+G++C
  EFC39096.1 184 SSVCNYNGNCTATN-NCVCNQGYSGNQC 210
                 689*******9666.8************ PP

  == domain 4  score: 20.7 bits;  conditional E-value: 1.1e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +++ +C+C+sgy+G++C
  EFC39096.1 228 SVCNGNGNCTSTN-NCVCKSGYTGNQC 253
                 57*******9666.8************ PP

  == domain 5  score: 19.7 bits;  conditional E-value: 2.3e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +++ +C+C+sgy+G++C
  EFC39096.1 271 SVCSGNGNCTSSN-NCECKSGYTGNQC 296
                 68*******9888.8************ PP

  == domain 6  score: 21.1 bits;  conditional E-value: 8.4e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +++ +C+C+sgy+G++C
  EFC39096.1 314 SVCNGNGNCTSSN-NCVCKSGYSGNQC 339
                 67*******9888.8************ PP

  == domain 7  score: 19.9 bits;  conditional E-value: 2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C+g+G C +++ +C+C++gy+G++C
  EFC39096.1 360 ISVCSGNGNCTSAN-NCECKAGYSGNQC 386
                 578*******9899.8************ PP

  == domain 8  score: 19.4 bits;  conditional E-value: 2.9e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C +++ +C+C+sgy+G++C
  EFC39096.1 403 SSVCNGNGNCTSSN-NCECKSGYTGNQC 429
                 689*******9888.8************ PP

  == domain 9  score: 20.5 bits;  conditional E-value: 1.3e-07
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGktC 32 
                  C+g+G C +++ +C+C+sgy+G++C
  EFC39096.1 448 VCNGNGNCTSSN-NCVCKSGYSGNQC 472
                 7*******9888.8************ PP

  == domain 10  score: 21.7 bits;  conditional E-value: 5.3e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghG+C +++  C+C++gy+G++C
  EFC39096.1 492 SVCSGHGICSSTN-DCQCENGYSGNKC 517
                 57*******9666.9************ PP

  == domain 11  score: 18.7 bits;  conditional E-value: 4.5e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +++ +C+C+sg++G++C
  EFC39096.1 538 TVCSGNGNCTSTN-NCQCQSGFSGNKC 563
                 56*******9666.8************ PP

  == domain 12  score: 7.8 bits;  conditional E-value: 0.0012
       EGF_2   4 s.deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 + ++ Cgg  +G+C +   +C+C+ +y G +C
  EFC39096.1 576 NdNNVCGGpdRGKCTSND-VCECKGSYVGYDC 606
                 3489**********9555.9**********99 PP

>> Bacteriocin_IId  Bacteriocin class IId cyclical uberolysin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       3.5   1.3e+04       2      18 ..     787     803 ..     787     809 .. 0.68
   2 ?    3.7   0.1      0.02        71      22      59 ..    1093    1130 ..    1088    1134 .. 0.88
   3 !   12.8   0.0   2.9e-05      0.11      12      55 ..    1328    1370 ..    1320    1380 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3.5
  Bacteriocin_IId   2 gtlGisktlAtkvvdii 18 
                      + lGis+tl +   ++i
       EFC39096.1 787 SKLGISETLKSYAQNMI 803
                      56899998866555555 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.02
  Bacteriocin_IId   22 stvasiisiitailsaGailaigasaviatvkkkikkn 59  
                       s  ++i + + a++s   ++++ +  +++ ++ +i ++
       EFC39096.1 1093 SFNVVIMTSVCAVISSALLASAVWCYFVMSIRFIIHRY 1130
                       556889999***********999********9999876 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 2.9e-05
  Bacteriocin_IId   12 tkvvdiidtgstvasiisiitailsaGailaigasaviatvkkk 55  
                        + vdi+d+++ ++ +  ++  i+s G+ + + ++++  t k  
       EFC39096.1 1328 IQTVDILDAVAFLFEVLMTVCLITSFGGFSVG-WAIFTETRKRS 1370
                       456*************************9877.***99887765 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.3   1.9e-06    0.0067       4     117 ..    1404    1550 ..    1401    1551 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 1.9e-06
                  HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...............SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.. CS
         RGS    4 slledqpgrslFreFlesefseenlsFwlaveefkka...............keqeelkkkakeIyneylapsspkelnidkklreelekrleke.. 83  
                  +l++++++++lF+++ + e s en   w+ +e+ +++               +e ++l+++    ++ +l+p+++  ln++++ +++  + ++    
  EFC39096.1 1404 KLMKNKYLLRLFQQYAKLEMSLENYIVWMRIEHARSKfaklwvdmdgeaasiEEWNSLLEELLGWLKDHLDPDAELALNVSHHSVKQFIAAVHMLes 1500
                  799**********************************************888666667777777788888888888888888888887766665556 PP

                  .................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS   84 .................qpsrklfeeaqeevfellekdsypkFlkselylr 117 
                                   +  r++ + +   v+  l +d y++F+ ++ y++
  EFC39096.1 1501 kidtistknrdslfnlkEMVRQAIDSLIIDVLYNL-TDTYSRFIITDEYKA 1550
                  77777877777776554556666666666666665.588999999988886 PP

>> DUF4413  Domain of unknown function (DUF4413)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.2    0.0011       3.9      13      68 ..     730     790 ..     716     795 .. 0.83
   2 ?    6.2   0.0    0.0036        13      21      78 ..     784     852 ..     771     868 .. 0.67

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0011
     DUF4413  13 neilevkkllkewakseddllskmaekmqekfdkyw.k.....ksnlllaiaviLDPryKlk 68 
                 +ei +v k+l++  +++++++s ++++++e++++y  +     +s+ll +  v LD ++Kl 
  EFC39096.1 730 KEIAQVTKQLNQI-TNQQQFISTVVSTLKENVNNYTiDdgldlTSSLLDISNVKLDTKSKLG 790
                 7899********9.99999****************965888876777666677788888875 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0036
     DUF4413  21 llkewakseddllskmaekmqekfdkywk............ksnlllaiaviLDPryKlkyvefalkkiy 78 
                 + k++    +++l++ a++m ekfd++ +              + +l  +++  P +K+ ++ ++++++ 
  EFC39096.1 784 DTKSK-LGISETLKSYAQNMIEKFDNFTTeqvkpvainivsVASNILNQSIFTEPSSKFVVIGNSIQSVE 852
                 44443.44678999**************768888844444433333444444457777777777776665 PP

>> CelTOS  Cell-traversal protein for ookinetes and sporozoites
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   2.9   5.7e-05       0.2      11      98 ..     726     820 ..     718     834 .. 0.72
   2 ?   -1.4   0.0      0.83     3e+03      57      86 ..    1512    1541 ..    1497    1548 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.7e-05
      CelTOS  11 kslssklseiiradldskgde......lvdliandlekelqknsl.vaasfLqsgfdvk..kkaKeiiKkvllevlksllpvvekivadavkPPvvd 98 
                   + +++ + + ++l++++++      +v+++ +++ +    ++l +++s+L+ + +vk  +k K  i ++l++  +++++ ++++ ++ vkP  ++
  EFC39096.1 726 TLTAKEIAQ-VTKQLNQITNQqqfistVVSTLKENVNNYTIDDGLdLTSSLLDIS-NVKldTKSKLGISETLKSYAQNMIEKFDNFTTEQVKPVAIN 820
                 455667777.778888888744422224555555555555567774578888855.56644999999**************************8776 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.83
      CelTOS   57 sgfdvkkkaKeiiKkvllevlksllpvvek 86  
                  s f++k+ +++ i + +++vl +l ++  +
  EFC39096.1 1512 SLFNLKEMVRQAIDSLIIDVLYNLTDTYSR 1541
                  557777788888888887777766665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1564 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1742  (0.097161); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.09u 0.37s 00:00:01.46 Elapsed: 00:00:00.53
# Mc/sec: 8949.59
//
Query:       EFC39097.1  [L=1084]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.2e-52  176.6   0.6    1.4e-51  175.4   0.1    1.8  2  Pkinase      Protein kinase domain
    3.1e-46  157.7   0.3    3.2e-39  134.8   0.1    2.3  2  Pkinase_Tyr  Protein tyrosine kinase
     0.0038   17.2   0.0      0.012   15.6   0.0    1.8  2  APH          Phosphotransferase enzyme family
  ------ inclusion threshold ------
      0.026   13.8   0.0      0.065   12.5   0.0    1.6  1  Kinase-like  Kinase-like
        2.6    8.7  24.4        3.3    8.4   0.6    6.8  6  Chlam_PMP    Chlamydia polymorphic membrane protein (Chlamydi


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       0.6   2.2e+03      61      90 ..     609     638 ..     602     653 .. 0.80
   2 !  175.4   0.1   3.9e-55   1.4e-51       3     259 ..     765    1073 ..     763    1076 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.6
                 --EEEEEEESSEEEEEEE--TTEBHHHHHH CS
     Pkinase  61 vrlyevfeekdelylvleyveggeladlle 90 
                 ++ly vf++++++ l++++ ++ge+ + +e
  EFC39097.1 609 ITLYTVFTSNTDFKLLFDLNNKGEISTTVE 638
                 899********************9988876 PP

  == domain 2  score: 175.4 bits;  conditional E-value: 3.9e-55
                  EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH...HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HH CS
     Pkinase    3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkke...kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rk 92  
                   ++k+GeGs+G+Vy ++  +++  vA+K ik+++++ + e   +++ +E ++l++l+hpn++ +y++    +  y+v+ey  +g+l+++++    +k
  EFC39097.1  765 IVSKIGEGSNGVVYLGR--WKQTDVALKSIKHDSTDIDIEnqlEEFEHEASLLASLRHPNVISFYGISFGLNVQYMVVEYSVNGSLDKAIHqskiKK 859 
                  679*************9..8999*********9987666657899*********************************************9888888 PP

                  SS--HHHHHHHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS.BCTTTSCGGGS-HHHHTTSCB..SHHHHHHHH CS
     Pkinase   93 gslseeeakkiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk.ltsfvgtseYlAPEvlkeney..skkvDvWsl 183 
                  ++ls ++  +i+  i +gl+ylHs +   i+HrDlKp NiL+d++ e K+tDFG+++ + ++++ +t  vgt +Y+APE+ ++ ++   + vDv+s 
  EFC39097.1  860 KVLSFRDKINIVLGISKGLNYLHSLRpqmIVHRDLKPGNILLDSNFEPKVTDFGMSRFIGTENSsMTMNVGTLRYCAPEIFNNDKHdaNHMVDVYSF 956 
                  889999*****************987777**************9999************998888****************5544434899****** PP

                  HHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS........................................-HHHHH CS
     Pkinase  184 Gvilyelltgkppfsgekgkekvekeldqlekilkilg.etkeklpeasei........................................seeakd 239 
                   +i+yell++  pfs++++k k+++    +  +  +     +++++e ++i                                         e+ ++
  EFC39097.1  957 SMIMYELLFEDAPFSENTKKMKNRSSGISTSDSSSVTSgSGSNNINEMYSIpvrvvrgerpsipfsnenelemwadefitdnaslnykvqaLEQYIE 1053
                  ***************6655554444333334444444347777888888889999***********************************999**** PP

                  HHHHHT-SSGCCSTTHHHHH CS
     Pkinase  240 llkkllkkdpkkRltaeell 259 
                  l+k+++++ p++R+++ ++ 
  EFC39097.1 1054 LMKQCWAQAPNQRPSFGQIS 1073
                  ***************99885 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  134.8   0.1     9e-43   3.2e-39       2     208 ..     764     972 ..     763     993 .. 0.88
   2 !   21.0   0.0   4.7e-08   0.00017     216     259 .]    1033    1076 ..    1011    1076 .. 0.82

  Alignments for each domain:
  == domain 1  score: 134.8 bits;  conditional E-value: 9e-43
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSS....HHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeat....eeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk 95 
                  ++ +k+GeG+ G V+ g++k      +++Va+K++k+++t    e++ ee+ +ea+++ +l+hpn+++++g+    +  ++v+ey  +G+L+k ++++
   EFC39097.1 764 QIVSKIGEGSNGVVYLGRWK------QTDVALKSIKHDSTdidiENQLEEFEHEASLLASLRHPNVISFYGISFGLNVQYMVVEYSVNGSLDKAIHQS 855
                  67899***************......99*******998872222456899************************9999******************99 PP

                  ..CTTTSBHHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..EEHHH CS
  Pkinase_Tyr  96 ..ekekltlkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk..ftsks 186
                    +k+ l+++d+++++l ++kG++yL+s +   +vHrdl   N+Ll++n   k++DfG++r i    e ++ + +   ++++apE++++ k   ++  
   EFC39097.1 856 kiKKKVLSFRDKINIVLGISKGLNYLHSLRpqmIVHRDLKPGNILLDSNFEPKVTDFGMSRFI--GTENSSMTMNVGTLRYCAPEIFNNDKhdANHMV 951
                  778999*********************9655559*****************************..55556677788999*********999778899* PP

                  HHHHHHHHHHHHHTTSSGTTTT CS
  Pkinase_Tyr 187 DvWsfGvllwEiftlgespypg 208
                  Dv+sf+++++E++   + p+++
   EFC39097.1 952 DVYSFSMIMYELLF-EDAPFSE 972
                  ***********987.4555544 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 4.7e-08
                   HHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  216 eklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259 
                   e+++++  l+   ++ e+  elmk+cw++ p++Rp+f ++ e+l
   EFC39097.1 1033 EFITDNASLNYKVQALEQYIELMKQCWAQAPNQRPSFGQISETL 1076
                   5678888899999999************************9876 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   3.3e-06     0.012     160     197 ..     881     916 ..     851     918 .. 0.84
   2 ?   -3.1   0.0       1.6   5.8e+03     112     161 ..    1018    1067 ..    1014    1073 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 3.3e-06
                 --SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 160 lpgelptvllHgDlhpgNllvdpddgrvtGviDfedag 197
                 l++  p+ ++H+Dl+pgN+l+d++  +   v Df++++
  EFC39097.1 881 LHSLRPQMIVHRDLKPGNILLDSNFEPK--VTDFGMSR 916
                 45566799**************777777..88998875 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.6
                  TTTB-SHHCHTCCHHHHHHCHHH.CCCGCCTCCHHHHHHHHHHHHHHHH-- CS
         APH  112 alpladflaqdlellrqlesata.rllaselldlleeleeqvlaalaallp 161 
                  + p++ + +  ++ ++++ + +  +++  +l++ ++el +q +a+ +  +p
  EFC39097.1 1018 SIPFSNENELEMWADEFITDNASlNYKVQALEQ-YIELMKQCWAQAPNQRP 1067
                  567777778888888888888777777778888.77777777777776666 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   1.8e-05     0.065     159     258 ..     883     978 ..     851     983 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.8e-05
  Kinase-like 159 nLqakglvhgkftvdnllldekgglmlggftaLvragtkvvlseve....kgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwclklPltl 252
                  +L+ + +vh ++++ n+lld ++  ++++f+  +  gt+   s++       +  pE++++        k    h +d++   + +y +   ++P+ +
   EFC39097.1 883 SLRPQMIVHRDLKPGNILLDSNFEPKVTDFGMSRFIGTENS-SMTMnvgtLRYCAPEIFNN-------DKHDANHMVDVYSFSMIMYELLFEDAPFSE 972
                  678889**************************999999998.6665555556889999999.......556777999999999999999999999999 PP

  Kinase-like 253 ateeak 258
                   t+++k
   EFC39097.1 973 NTKKMK 978
                  988776 PP

>> Chlam_PMP  Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.2   3.0         5   1.8e+04       5      10 ..     153     158 ..     150     163 .. 0.69
   2 ?    5.1   0.0      0.01        38       4      26 ..     406     419 ..     404     420 .. 0.87
   3 ?    2.9   0.0     0.052   1.9e+02       3      26 ..     433     446 ..     431     447 .. 0.87
   4 ?    8.4   0.6   0.00093       3.3       2      27 ..     458     479 ..     457     480 .. 0.85
   5 ?    5.1   0.8      0.01        36       3      26 ..     490     503 ..     488     505 .. 0.86
   6 ?   -0.3   0.1      0.54     2e+03       1       9 [.     516     524 ..     516     551 .. 0.87

  Alignments for each domain:
  == domain 1  score: -5.2 bits;  conditional E-value: 5
   Chlam_PMP   5 snNtat 10 
                 +nN+++
  EFC39097.1 153 TNNSSG 158
                 577775 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.01
   Chlam_PMP   4 FsnNtatvsstptpaaggGGAIy 26 
                 F  N+           ++GGAIy
  EFC39097.1 406 FLRNSR---------LSNGGAIY 419
                 667888.........89*****9 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.052
   Chlam_PMP   3 tFsnNtatvsstptpaaggGGAIy 26 
                 +F++N a           +GGA y
  EFC39097.1 433 VFEDNMA----------LNGGAVY 446
                 7999999..........9****99 PP

  == domain 4  score: 8.4 bits;  conditional E-value: 0.00093
   Chlam_PMP   2 itFsnNtatvsstptpaaggGGAIya 27 
                 ++F+ N++t  +    ++g+GGA+y+
  EFC39097.1 458 TVFNRNKVTDCA----KCGNGGALYS 479
                 689999998776....*********7 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.01
   Chlam_PMP   3 tFsnNtatvsstptpaaggGGAIy 26 
                  F+nN a           +GGA +
  EFC39097.1 490 NFTNNVA----------IKGGAVF 503
                 59*****..........9****98 PP

  == domain 6  score: -0.3 bits;  conditional E-value: 0.54
   Chlam_PMP   1 sitFsnNta 9  
                 +i+F nN a
  EFC39097.1 516 DIVFQNNEA 524
                 699****99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1084 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       776  (0.0432818); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.79u 0.31s 00:00:01.10 Elapsed: 00:00:00.48
# Mc/sec: 6855.56
//
Query:       EFC39098.1  [L=355]
Description: hypothetical protein NAEGRDRAFT_73137 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.6e-33  114.8   3.4    8.9e-32  110.6   3.4    2.0  1  Carb_anhydrase  Eukaryotic-type carbonic anhydrase


Domain annotation for each model (and alignments):
>> Carb_anhydrase  Eukaryotic-type carbonic anhydrase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  110.6   3.4     5e-36   8.9e-32       1     252 [.      39     348 ..      39     350 .. 0.74

  Alignments for each domain:
  == domain 1  score: 110.6 bits;  conditional E-value: 5e-36
                     EBXXHHHBXGGGHHHHXC..CCCSSS-S-BEE-GGGCE......E-TT-EEEEEES..................TSSCEE..EEEEEE-SSSEEE CS
  Carb_anhydrase   1 ewsyeeekgpeeWsekyp..ecggkrQSPInietkkak......vdpslkplefeg..................ydkkek..kltlennGhtvqv 67 
                     +wsy+   + + W+++ p  +cgg++QSPI i+  +++      +     + + ++                  +d+ ++  ++++ nn ht+ +
      EFC39098.1  39 HWSYQ---KAAIWQQECPfsSCGGRSQSPISISLYQTTlyetyfM-----NAKAQSlimydfstddkrlivfrgIDNFFQqfSFSVINNNHTIVM 125
                     799*7...8899***97666************8877775444442.....3333333444466677777777775555544559********888 PP

                     ET.TT............TCSEEEETTESS.EEEEEEEEEESSSTTTSSSSEETTB--SEEEEEEEEET.TTSSHHHHTTSTTSEEEEEEEEEE.. CS
  Carb_anhydrase  68 kl.kd............ekptisggplsgkYrleqlhfHWGssdekGSEHtidgkrypaElhivhyns.kysslsealkkpdglavlgvllev.. 146
                     +  ++            +++  +  +++  Y l+q+h+H        SEH+++++++++Elh+v+ ++   s++seal    +lav+g+l++v  
      EFC39098.1 126 ESvNEesisiersfwirNNTWQTFNSITVPYYLKQFHLHS------PSEHLVNSESFDLELHLVFQRNdLPSNTSEALV--PKLAVVGILYKVll 212
                     875446799998888863323334445789*********7......7******************99978889999988..68*********534 PP

                     CS.--GGGHHHHHHG.GG..G-STTEEEEEEE...E-CGGGSSS.G.CS-EEEEEE--SSTT--S-EEEEEESSEE......EEEHHHHHHHHHC CS
  Carb_anhydrase 147 ge.enpeleklveal.kk..ikkkgksvslks...fslsdllpe.s.lskYyrYeGSLTtPpcseaVtWtvfkepi......kisekqlekfrsl 226
                     g  +np ++ +++++ +k  +  k   +++++   f+l +  ++ + l +Y+ Y+GSLTtP+c+e+V+W +++  i      +is++ql+++++l
      EFC39098.1 213 GAiDNPLVDIVIQNVlQKprVIGKPIPTTVTGgllFDLVTARQQfDpLYSYFVYNGSLTTPNCNENVMWNLINPNImsggyhYISSRQLTTLQQL 307
                     6699998886655541442233333345565546777777777775366********************99988764444447************ PP

                     BC...STTTSSB.................S-------B--TT--EE CS
  Carb_anhydrase 227 ls...eeeeekp.................lvnnfRpvqplngRkVr 252
                     ++         +                    n Rp+qplngR++ 
      EFC39098.1 308 MNqnkP-----HiaeganlgkvqintgsaYIGNNRPLQPLNGRTII 348
                     **3330.....2446777888888888889999**********995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       462  (0.0257683); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.54
# Mc/sec: 1961.29
//
Query:       EFC39099.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0042   17.0   0.3     0.0093   15.9   0.3    1.6  1  Sec7_N    Guanine nucleotide exchange factor in Golgi transpo


Domain annotation for each model (and alignments):
>> Sec7_N  Guanine nucleotide exchange factor in Golgi transport N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.3   5.2e-07    0.0093      22      57 ..     272     308 ..     255     375 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 5.2e-07
      Sec7_N  22 k.pkflslaersktfsLeLlesvlsnhgdvfrkhpel 57 
                 k  +  + +e+s t+sLeL+ svls+++++f++ ++ 
  EFC39099.1 272 KmLQRYGNKEISTTISLELVASVLSENKKLFNNYENC 308
                 1423247899*********************987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       847  (0.0472419); expected 358.6 (0.02)
Passed bias filter:                      598  (0.0333538); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 2160.73
//
Query:       EFC39100.1  [L=410]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.1e-30  104.5   3.4    5.7e-16   58.2   0.4    3.5  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0     3e-07    0.0055      14      93 ..      87     186 ..      80     188 .. 0.76
   2 !   58.2   0.4   3.2e-20   5.7e-16       6      95 ..     208     310 ..     203     312 .. 0.84
   3 !   28.8   0.1   4.9e-11   8.8e-07       7      75 ..     317     392 ..     311     405 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 3e-07
                 HHHHHHHHHHHHHHHHHHHHHH....................CCCSSTTTSCSS.............HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHH CS
   Mito_carr  14 lagavatlvttPldvvKtrlqt....................qkksskksksaa.............ildvlkkiykeeGlrglyrGllpnllrvapas 79 
                 ++  ++ l+++Pld++ t l t                    +          +             ++d+lkk+ k+   r l+rGl p + +   a+
  EFC39100.1  87 TSTFFSRLFAHPLDRISTILRTqhvlpnaygtsfytnlptavS----------SslvqpqqqapfrgAIDALKKLPKD---RTLWRGLAPDVYGRLCAK 172
                 688999****************666666655555555555441..........0445555555655588888888877...789*************** PP

                 HHHHHHHHHHHHHH CS
   Mito_carr  80 alkfvlyetlkrll 93 
                 ++ + + + + +++
  EFC39100.1 173 VVELQFADEINNFI 186
                 ****9999998876 PP

  == domain 2  score: 58.2 bits;  conditional E-value: 3.2e-20
                 HHHHHHHHHHHHHHHH.HHHHHHHHHHHHHH............CCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   6 lkellaGglagavatl.vttPldvvKtrlqt............qkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkr 91 
                 +k l++++++gava++ + +P+ vv tr+q+            + ++ +k++++++++ +k+iy+ eG+rg+y Gl++++ + a++++++f+l+++l+r
  EFC39100.1 208 TKVLATSVISGAVASFlISYPFSVVSTRMQSnliplhevkynmDWQMVNKTNFSNVWQSFKSIYQFEGIRGFYTGLSAAVSGLAVYRGIYFALFDSLRR 306
                 5678999******886257************888888877777444444445555*******************************************9 PP

                 HHCT CS
   Mito_carr  92 lllk 95 
                 l + 
  EFC39100.1 307 LGMS 310
                 9765 PP

  == domain 3  score: 28.8 bits;  conditional E-value: 4.9e-11
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS.......HHHHHHHHHHHHHHHGGGTTHHHHHHHH CS
   Mito_carr   7 kellaGglagavatlvttPldvvKtrlqtqkksskksksaa.......ildvlkkiykeeGlrglyrGllpnllrv 75 
                 +++l +  +  +a+l ++P+ ++  rl +q+   k  + ++       +ld++kkiy++eG+rg yrG++ +l  +
  EFC39100.1 317 EKFLYSQGCIFTAGLSAYPFRLIGDRLKAQAVFRKLYTEEEtqlfyrgTLDAMKKIYQQEGIRGYYRGFVFSLGTS 392
                 5666666666789999***********998877665554446778888*********************9987544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (410 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       901  (0.0502538); expected 358.6 (0.02)
Passed bias filter:                      596  (0.0332422); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2258.25
//
Query:       EFC39101.1  [L=439]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.2e-52  171.5  29.1    0.00011   21.9   0.0   14.3 14  LRR_6       Leucine Rich repeat
      6e-40  134.8  44.6    6.5e-08   32.2   0.8    6.2  8  LRR_8       Leucine rich repeat
    7.7e-27   92.9  32.0    0.00017   21.9   0.1    8.3  9  LRR_4       Leucine Rich repeats (2 copies)
    9.3e-16   56.0  21.9        5.2    8.0   0.0   13.6 15  LRR_1       Leucine Rich Repeat
    6.5e-09   35.5   7.3    0.00066   19.2   1.8    3.9  4  LRR_9       Leucine-rich repeat
     0.0012   18.7   1.9     0.0019   18.1   0.8    1.9  2  F-box-like  F-box-like
     0.0079   16.0   1.1      0.027   14.3   1.0    2.0  2  F-box       F-box domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.1   0.00014      0.35       4      18 ..     101     115 ..      99     120 .. 0.93
   2 !   20.1   1.1   1.7e-07   0.00043       2      24 .]     123     145 ..     122     145 .. 0.95
   3 !   11.0   0.1   0.00015      0.37       3      24 .]     148     169 ..     146     169 .. 0.90
   4 !   18.7   0.0   4.8e-07    0.0012       4      21 ..     173     190 ..     170     192 .. 0.90
   5 !   10.3   0.0   0.00023      0.58       5      23 ..     198     216 ..     195     217 .. 0.90
   6 !   21.9   0.0   4.4e-08   0.00011       5      24 .]     222     241 ..     219     241 .. 0.94
   7 !   14.5   0.0     1e-05     0.027       5      24 .]     246     265 ..     245     265 .. 0.92
   8 !   20.6   0.1   1.2e-07    0.0003       5      24 .]     270     289 ..     267     289 .. 0.95
   9 ?    2.4   0.0     0.081   2.1e+02       5      24 .]     294     313 ..     292     313 .. 0.92
  10 !   16.0   0.0   3.6e-06    0.0091       3      24 .]     316     337 ..     314     337 .. 0.91
  11 ?    2.5   0.0     0.075   1.9e+02       5      22 ..     342     359 ..     339     361 .. 0.83
  12 !   14.1   0.1   1.5e-05     0.037       5      22 ..     366     383 ..     363     385 .. 0.87
  13 !   13.8   0.0   1.7e-05     0.045       5      22 ..     390     407 ..     387     408 .. 0.91
  14 ?    0.6   0.1      0.31   8.1e+02       3      17 ..     412     426 ..     410     427 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00014
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +Lt  d+s+N+I+De
  EFC39101.1 101 NLTRIDISDNEISDE 115
                 8*************8 PP

  == domain 2  score: 20.1 bits;  conditional E-value: 1.7e-07
       LRR_6   2 nthLteLdLsgNdIgDeGaeaLa 24 
                  thLt L +++NdIg eGa++L+
  EFC39101.1 123 LTHLTNLVINCNDIGVEGAKCLC 145
                 69********************8 PP

  == domain 3  score: 11.0 bits;  conditional E-value: 0.00015
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt L++  N +  eGa+ ++
  EFC39101.1 148 NQLTRLNIGNNSLETEGAKYIS 169
                 579***************9885 PP

  == domain 4  score: 18.7 bits;  conditional E-value: 4.8e-07
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                 +Lt+Ld++ N+IgD Ga+
  EFC39101.1 173 NLTKLDIARNCIGDRGAQ 190
                 8***************97 PP

  == domain 5  score: 10.3 bits;  conditional E-value: 0.00023
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L+L+ N+I   Ga+ +
  EFC39101.1 198 LTSLNLNRNGIEYLGAKFI 216
                 9**************9977 PP

  == domain 6  score: 21.9 bits;  conditional E-value: 4.4e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+s NdIg eGa+ ++
  EFC39101.1 222 LTSLDISNNDIGSEGAKQIS 241
                 9****************986 PP

  == domain 7  score: 14.5 bits;  conditional E-value: 1e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L + +N+IgDeGa+ ++
  EFC39101.1 246 LTKLYIYDNNIGDEGAMHIS 265
                 8999999**********986 PP

  == domain 8  score: 20.6 bits;  conditional E-value: 1.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+s NdI+ eGa++++
  EFC39101.1 270 LTNLDISRNDIDSEGAKSIC 289
                 9*****************98 PP

  == domain 9  score: 2.4 bits;  conditional E-value: 0.081
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L++ +N Ig  Ga+ ++
  EFC39101.1 294 LTNLNICSNYIGETGAKHIS 313
                 999*************9986 PP

  == domain 10  score: 16.0 bits;  conditional E-value: 3.6e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt L++ +N+Ig eGa  ++
  EFC39101.1 316 NNLTILEIGSNEIGSEGAYHIS 337
                 79****************9885 PP

  == domain 11  score: 2.5 bits;  conditional E-value: 0.075
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt L +  NdIg +Ga+ 
  EFC39101.1 342 LTRLMIFANDIGEKGAKH 359
                 88888889********96 PP

  == domain 12  score: 14.1 bits;  conditional E-value: 1.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+ +N+IgDeG + 
  EFC39101.1 366 LTKLDIYDNNIGDEGTIH 383
                 9**************665 PP

  == domain 13  score: 13.8 bits;  conditional E-value: 1.7e-05
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+s N+Ig eGae 
  EFC39101.1 390 LTYLDVSANNIGHEGAEY 407
                 9***************96 PP

  == domain 14  score: 0.6 bits;  conditional E-value: 0.31
       LRR_6   3 thLteLdLsgNdIgD 17 
                 + Lt L++ +N ++D
  EFC39101.1 412 NRLTFLNVHYNSFSD 426
                 679********9998 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1      0.65   1.7e+03       5      26 ..      58      79 ..      58      82 .. 0.81
   2 !   31.6   2.3     4e-11     1e-07       2      61 .]     101     160 ..     100     160 .. 0.98
   3 !   29.2   2.9   2.2e-10   5.6e-07       2      61 .]     149     208 ..     148     208 .. 0.98
   4 !   32.2   0.8   2.5e-11   6.5e-08       2      61 .]     173     232 ..     172     232 .. 0.98
   5 !   32.1   1.9   2.7e-11   6.9e-08       2      61 .]     197     256 ..     196     256 .. 0.98
   6 !   27.5   0.5   7.6e-10     2e-06       2      61 .]     221     280 ..     220     280 .. 0.98
   7 !   27.4   0.1   8.3e-10   2.1e-06       2      61 .]     293     352 ..     292     352 .. 0.98
   8 !   26.2   0.1   1.9e-09   4.8e-06       2      60 ..     365     423 ..     364     424 .. 0.97

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.65
                EEE-TTS--SEE-TTSSTT-TT CS
       LRR_8  5 sLdLsnNrltslddeaFkglsn 26
                +L+L++N+ ++l+ ++ +++sn
  EFC39101.1 58 KLSLTCNSDQKLKGKFLERVSN 79
                6999999999999888887776 PP

  == domain 2  score: 31.6 bits;  conditional E-value: 4e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt++d+s+N +++ + + F +l++L+ L +++N + +  ++++ +L++L+ L++ +N L
  EFC39101.1 101 NLTRIDISDNEISDERVKHFGNLTHLTNLVINCNDIGVEGAKCLCQLNQLTRLNIGNNSL 160
                 9*********************************************************87 PP

  == domain 3  score: 29.2 bits;  conditional E-value: 2.2e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++ nN+l+  + +  + l+nL+ Ld+ +N++    ++ +  +++L+sL+L++N +
  EFC39101.1 149 QLTRLNIGNNSLETEGAKYISELKNLTKLDIARNCIGDRGAQFITEMKQLTSLNLNRNGI 208
                 79********************************************************86 PP

  == domain 4  score: 32.2 bits;  conditional E-value: 2.5e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+Ld+ +N + + + ++ + +++L++L+L++N ++ l ++ +s + +L+sLd+s+N++
  EFC39101.1 173 NLTKLDIARNCIGDRGAQFITEMKQLTSLNLNRNGIEYLGAKFISEMYQLTSLDISNNDI 232
                 9*********************************************************97 PP

  == domain 5  score: 32.1 bits;  conditional E-value: 2.7e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL+L++N ++ l+ ++ + + +L++Ld+snN + +  ++ +s L +L++L++ +N++
  EFC39101.1 197 QLTSLNLNRNGIEYLGAKFISEMYQLTSLDISNNDIGSEGAKQISKLDQLTKLYIYDNNI 256
                 7*******************************************************9997 PP

  == domain 6  score: 27.5 bits;  conditional E-value: 7.6e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+snN + s + ++ ++l +L+ L++ +N++    +  +s +++L+ Ld+s+N++
  EFC39101.1 221 QLTSLDISNNDIGSEGAKQISKLDQLTKLYIYDNNIGDEGAMHISEMKQLTNLDISRNDI 280
                 69********************************************************97 PP

  == domain 7  score: 27.4 bits;  conditional E-value: 8.3e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++++N++ + + +  + ++nL++L++++N++ +  +  +s +++L+ L +  N++
  EFC39101.1 293 QLTNLNICSNYIGETGAKHISEMNNLTILEIGSNEIGSEGAYHISRMHQLTRLMIFANDI 352
                 69*****************************************************99997 PP

  == domain 8  score: 26.2 bits;  conditional E-value: 1.9e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+Ld+ +N++ + +    + +++L++Ld s N++ +  ++ ++ L++L++L++ +N 
  EFC39101.1 365 QLTKLDIYDNNIGDEGTIHISEMKQLTYLDVSANNIGHEGAEYIRKLNRLTFLNVHYNS 423
                 7********************************************************96 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.9   1.7e-06    0.0044       1      39 [.     100     136 ..     100     142 .. 0.90
   2 !   18.2   0.6   9.8e-07    0.0025       2      36 ..     149     184 ..     148     187 .. 0.85
   3 !   21.4   0.5   9.7e-08   0.00025       1      37 [.     172     209 ..     172     217 .. 0.85
   4 !   20.2   1.0   2.2e-07   0.00056       1      39 [.     196     232 ..     196     245 .. 0.87
   5 !   21.9   0.1   6.4e-08   0.00017       2      40 ..     245     281 ..     244     291 .. 0.90
   6 !   10.4   3.2   0.00028      0.71       1      37 [.     268     305 ..     268     332 .. 0.86
   7 ?    5.3   0.0     0.011        27       2      33 ..     317     350 ..     316     354 .. 0.77
   8 !   21.9   0.1   6.8e-08   0.00017       1      34 [.     364     399 ..     364     402 .. 0.86
   9 ?    2.6   0.1     0.081   2.1e+02      19      41 ..     408     426 ..     403     433 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.7e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +nL+ +d+s+N ++d     +++l++L+ L ++ N    d+
  EFC39101.1 100 KNLTRIDISDNEISDERVkhFGNLTHLTNLVINCN----DI 136
                 79*************99999999*******99666....55 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 9.8e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L+ L+++nN l + +   ++ l+nL++Ld+ +N  i
  EFC39101.1 149 QLTRLNIGNNSLETEGAkyISELKNLTKLDIARN-CI 184
                 69***********988886445*********888.55 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 9.7e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 +nL++Ld++ N++ d +  +   +++L++L+L++N  i+
  EFC39101.1 172 KNLTKLDIARNCIGDRGAqFITeMKQLTSLNLNRN-GIE 209
                 79************988895544*********888.554 PP

  == domain 4  score: 20.2 bits;  conditional E-value: 2.2e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdl 39 
                 ++L++L+L+ N +  ++  + + + +L++Ld+s+N    d+
  EFC39101.1 196 KQLTSLNLNRNGIEYLGAkFISeMYQLTSLDISNN----DI 232
                 58*****************6655*********999....66 PP

  == domain 5  score: 21.9 bits;  conditional E-value: 6.4e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GG CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdld 40 
                 +L++L++ +N++ d +   ++ +++L+ Ld+s+N    d+d
  EFC39101.1 245 QLTKLYIYDNNIGDEGAmhISEMKQLTNLDISRN----DID 281
                 69************99997556************....996 PP

  == domain 6  score: 10.4 bits;  conditional E-value: 0.00028
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 ++L++Ld+s N + + +    +e l +L+ L++ +N +i+
  EFC39101.1 268 KQLTNLDISRNDIDSEGAksiCE-LYQLTNLNICSN-YIG 305
                 589***********988886544.********9677.775 PP

  == domain 7  score: 5.3 bits;  conditional E-value: 0.011
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgN 33 
                 nL++L +++N + + +   + + + +L+ L +  N
  EFC39101.1 317 NLTILEIGSNEIGSEGAyhI-SrMHQLTRLMIFAN 350
                 9************9888652.44999999966335 PP

  == domain 8  score: 21.9 bits;  conditional E-value: 6.8e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++Ld+ +N++ d +   ++ +++L++Ld+s Nn
  EFC39101.1 364 KQLTKLDIYDNNIGDEGTihISEMKQLTYLDVSANN 399
                 58*************99965335*********9994 PP

  == domain 9  score: 2.6 bits;  conditional E-value: 0.081
                 HHH-TT--EEE-.-S-----GGG CS
       LRR_4  19 leklpnLkeLdLsgNnlitdlde 41 
                 ++kl  L+ L+++ N    ++++
  EFC39101.1 408 IRKLNRLTFLNVHYN----SFSD 426
                 567999999999889....4443 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1         7   1.8e+04       7      16 ..      15      24 ..      11      32 .. 0.57
   2 ?   -2.5   0.0       5.7   1.5e+04       7      19 ..      54      65 ..      51      70 .. 0.61
   3 !    7.8   0.0    0.0023       5.9       1      23 []     101     123 ..     101     123 .. 0.94
   4 ?    0.8   0.3      0.47   1.2e+03       1      22 [.     122     146 ..     122     147 .. 0.69
   5 !    7.8   0.0    0.0024       6.2       1      21 [.     149     169 ..     149     171 .. 0.82
   6 !    6.4   0.0    0.0067        17       1      16 [.     173     188 ..     173     194 .. 0.83
   7 ?    4.3   0.0     0.033        85       1      17 [.     197     213 ..     197     219 .. 0.77
   8 !    8.0   0.0     0.002       5.2       1      22 [.     221     242 ..     221     243 .. 0.79
   9 ?    2.2   0.0      0.17   4.3e+02       1      17 [.     245     261 ..     245     267 .. 0.78
  10 !    6.2   0.1    0.0077        20       2      23 .]     270     291 ..     269     291 .. 0.89
  11 ?    2.1   0.0      0.18   4.6e+02       2      20 ..     294     312 ..     293     315 .. 0.77
  12 ?    2.4   0.0      0.14   3.7e+02       1      19 [.     317     335 ..     317     339 .. 0.80
  13 ?    2.8   0.0      0.11   2.7e+02       1      14 [.     365     378 ..     365     386 .. 0.79
  14 ?    3.8   0.0      0.05   1.3e+02       1      23 []     389     411 ..     389     411 .. 0.85
  15 ?    2.2   0.1      0.17   4.3e+02       1      20 [.     413     432 ..     413     434 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 7
       LRR_1  7 Lsnnpllglp 16
                +sn+++ g +
  EFC39101.1 15 ISNQFPCGDI 24
                4666664444 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 5.7
       LRR_1  7 Lsnnpllglppns 19
                L+++ l +l+ ns
  EFC39101.1 54 LERCKL-SLTCNS 65
                677777.454444 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0023
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+++d+s+n +++    +f nL
  EFC39101.1 101 NLTRIDISDNEISDERVKHFGNL 123
                 8***********99999999987 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.47
       LRR_1   1 nLrhL.d..Lsnnpllglppnsfqn 22 
                 nL+hL +  ++ n ++  ++ +++ 
  EFC39101.1 122 NLTHLtNlvINCNDIGVEGAKCLCQ 146
                 5666642337999999999888876 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.0024
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L+++nn+l+  ++ +++
  EFC39101.1 149 QLTRLNIGNNSLETEGAKYIS 169
                 599*********888877776 PP

  == domain 6  score: 6.4 bits;  conditional E-value: 0.0067
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 nL++Ld+ +n++++ +
  EFC39101.1 173 NLTKLDIARNCIGDRG 188
                 8*********997665 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.033
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L+L++n ++ l++
  EFC39101.1 197 QLTSLNLNRNGIEYLGA 213
                 599*******9866555 PP

  == domain 8  score: 8.0 bits;  conditional E-value: 0.002
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++Ld+snn +++ ++  +++
  EFC39101.1 221 QLTSLDISNNDIGSEGAKQISK 242
                 599********98777766665 PP

  == domain 9  score: 2.2 bits;  conditional E-value: 0.17
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++ +n++++ ++
  EFC39101.1 245 QLTKLYIYDNNIGDEGA 261
                 599*******9977665 PP

  == domain 10  score: 6.2 bits;  conditional E-value: 0.0077
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L+ Ld+s+n +++ ++ s++ L
  EFC39101.1 270 LTNLDISRNDIDSEGAKSICEL 291
                 899********99999999875 PP

  == domain 11  score: 2.1 bits;  conditional E-value: 0.18
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ L++++n ++  ++ ++
  EFC39101.1 294 LTNLNICSNYIGETGAKHI 312
                 899******9976666665 PP

  == domain 12  score: 2.4 bits;  conditional E-value: 0.14
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL+ L +++n +++ ++ +
  EFC39101.1 317 NLTILEIGSNEIGSEGAYH 335
                 8*********997766655 PP

  == domain 13  score: 2.8 bits;  conditional E-value: 0.11
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++Ld+ +n++++
  EFC39101.1 365 QLTKLDIYDNNIGD 378
                 599****9999844 PP

  == domain 14  score: 3.8 bits;  conditional E-value: 0.05
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++Ld+s n++++ +++++ +L
  EFC39101.1 389 QLTYLDVSANNIGHEGAEYIRKL 411
                 599********999988887765 PP

  == domain 15  score: 2.2 bits;  conditional E-value: 0.17
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+ L++ +n++++ +++ +
  EFC39101.1 413 RLTFLNVHYNSFSDSESELI 432
                 6999*******988777655 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   1.8   2.6e-07   0.00066      44     129 ..     102     188 ..      94     205 .. 0.84
   2 !    8.7   0.1   0.00044       1.1      63     129 ..     195     260 ..     187     277 .. 0.74
   3 !    9.6   0.1   0.00024      0.61      41     144 ..     243     347 ..     241     364 .. 0.79
   4 ?    2.1   0.0     0.046   1.2e+02      43      97 ..     365     418 ..     354     433 .. 0.51

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 2.6e-07
       LRR_9  44 fdtidlsdndir..kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                 +  id+sdn+i   ++  f  l  l  l++n n i   + +    l +l+ l + nn+l+  +  + + +lk+l+ l + +n + ++ 
  EFC39101.1 102 LTRIDISDNEISdeRVKHFGNLTHLTNLVINCNDIGVEGAKCLCQLNQLTRLNIGNNSLETEGA-KYISELKNLTKLDIARNCIGDRG 188
                 667********63379*******************9999999999**************98887.99***************997764 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00044
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                 +k+l +l ln n i  ++ ++   + +l++l ++nn + + +  + + +l +l+ l + +n + ++ 
  EFC39101.1 195 MKQLTSLNLNRNGIEYLGAKFISEMYQLTSLDISNNDIGSEGA-KQISKLDQLTKLYIYDNNIGDEG 260
                 7788888889999999988888888889999999998888777.77888888888888888776544 PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00024
       LRR_9  41 ldqfdtidlsdndirkldg..fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviy 137
                 ldq+  + + dn+i +     +  +k+l  l ++ n i   + +    l +l++l + +n + e +  + + ++++l++l + +n + ++  y    ++
  EFC39101.1 243 LDQLTKLYIYDNNIGDEGAmhISEMKQLTNLDISRNDIDSEGAKSICELYQLTNLNICSNYIGETGA-KHISEMNNLTILEIGSNEIGSEGAYHISRMH 340
                 7888888888888877554114557888888889999988877777788899999999999999887.8899999999999999999999999888888 PP

       LRR_9 138 klkqlrl 144
                 +l +l +
  EFC39101.1 341 QLTRLMI 347
                 8877765 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.046
       LRR_9  43 qfdtidlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltn 97 
                 q+  +d+ dn+i + +g  ++  +k l   +    +i+++ +e++ +l+ l + n
  EFC39101.1 365 QLTKLDIYDNNIGD-EGTIHISEMKQLTYLDVSANNIGHEGAEYIRKLNRLTFLN 418
                 55566666666655.3333333333333333333333444444444444444444 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.8   7.3e-07    0.0019       7      36 ..      23      54 ..      22      63 .. 0.88
   2 ?   -2.7   0.0       2.2   5.6e+03      10      16 ..      93      99 ..      93     106 .. 0.76

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 7.3e-07
  F-box-like  7 EiLlqIFsyL.pps.dLlrlalVCrrWrrval 36
                +iL +I+s+  +++    ++alV+++W+ v+l
  EFC39101.1 23 DILWEILSFCnDFTfIVMNCALVSKQWYHVIL 54
                69******87688877999***********96 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.2
  F-box-like 10 lqIFsyL 16
                +qIF++L
  EFC39101.1 93 CQIFECL 99
                79**998 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   1.0   1.1e-05     0.027       9      38 ..      23      54 ..      21      64 .. 0.90
   2 ?   -2.3   0.1       1.7   4.4e+03      22      32 ..      55      65 ..      54      67 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.1e-05
                HHHHHHHHTS-HHH..HHHHCTT-HHHHHHHT CS
       F-box  9 evlrhILerLplsd..llalrrVSkgwrilid 38
                ++l +IL++++  +  + ++++VSk w+ +i 
  EFC39101.1 23 DILWEILSFCNDFTfiVMNCALVSKQWYHVIL 54
                7999************************9986 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.7
                HHHHHCTT-HH CS
       F-box 22 dllalrrVSkg 32
                +++ l++++ +
  EFC39101.1 55 ERCKLSLTCNS 65
                5899****975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (439 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       459  (0.025601); expected 358.6 (0.02)
Passed bias filter:                      254  (0.014167); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2425.53
//
Query:       EFC39102.1  [L=226]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.016   15.7   0.1      0.032   14.7   0.1    1.6  2  LEA_2     Late embryogenesis abundant protein


Domain annotation for each model (and alignments):
>> LEA_2  Late embryogenesis abundant protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0      0.63   1.1e+04      18      29 ..      86      97 ..      84     100 .. 0.76
   2 ?   14.7   0.1   1.8e-06     0.032       2      53 ..     104     158 ..     103     200 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 0.63
                EEEEEESSSEEE CS
       LEA_2 18 eldlsyngqrla 29
                + ++syn++ l+
  EFC39102.1 86 SCTFSYNNATLG 97
                678999999988 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 1.8e-06
                 EEEEESSSS-EEEEEEEEEEEESSSEEEEEEECE-EEESSSCEEEEEEE....EEE CS
       LEA_2   2 lrvrNPNsfgvrydgleldlsyngqrlasgtspqgfsqpargtttlevp....vsv 53 
                 +r +N N f + ++ + +++ y+ ++++ +  +++  ++++ t++++vp     s+
  EFC39102.1 104 VRATNGNLFNISLNAVKIEIMYGSEVIG-SSASESYPVGPQTTQDVNVPiiwkSSL 158
                 899*************************.9999999999*9999999995554444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (226 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       889  (0.0495845); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1541.99
//
Query:       EFC39103.1  [L=1141]
Description: pyruvate phosphate dikinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.3e-88  295.2   0.1    6.8e-88  294.6   0.1    1.3  1  PEP-utilizers_C  PEP-utilising enzyme, TIM barrel domain
    1.3e-58  198.9   0.1    1.3e-45  156.1   0.0    2.4  2  PPDK_N           Pyruvate phosphate dikinase, PEP/pyruvate bi
    8.6e-49  165.5   0.0    3.2e-48  163.7   0.0    2.0  1  ADK              Adenylate kinase
    3.5e-34  118.2   0.2    2.7e-33  115.3   0.0    2.6  2  AAA_17           AAA domain
    8.1e-22   76.7   0.2      2e-21   75.5   0.2    1.7  1  PEP-utilizers    PEP-utilising enzyme, mobile domain
    8.3e-10   39.3   0.0    3.5e-09   37.3   0.0    2.2  1  AAA_18           AAA domain
    4.2e-06   27.0   0.0    5.4e-05   23.4   0.0    2.5  2  AAA_33           AAA domain
    0.00082   19.1   1.2       0.46   10.1   0.0    3.0  2  Thymidylate_kin  Thymidylate kinase
     0.0066   15.6   0.0      0.013   14.6   0.0    1.4  1  HpcH_HpaI        HpcH/HpaI aldolase/citrate lyase family
  ------ inclusion threshold ------
      0.014   15.5   0.1        5.8    7.1   0.0    3.0  3  HTH_48           HTH domain in Mos1 transposase
      0.036   13.9   2.4        0.1   12.4   0.3    2.5  2  RB_A             Retinoblastoma-associated protein A domain
      0.045   14.0   1.8      0.063   13.5   0.5    1.9  2  DUF4142          Domain of unknown function (DUF4142)
       0.11   12.2   0.1       0.61    9.8   0.0    2.1  2  Cytidylate_kin   Cytidylate kinase


Domain annotation for each model (and alignments):
>> PEP-utilizers_C  PEP-utilising enzyme, TIM barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  294.6   0.1     5e-91   6.8e-88       7     292 ..     603     952 ..     599     954 .. 0.94

  Alignments for each domain:
  == domain 1  score: 294.6 bits;  conditional E-value: 5e-91
                      CCCCCCCHCCCXBCEEEEEESSCHHHHHHHHCTXSSEEEEEHHHHCTTSCCHHHHHH....................HHHHHHHHHHHTTTSEE CS
  PEP-utilizers_C   7 lktllavtkdgkkikvlaNidtpedaekalengaeGiGLlRtEflfmareelpteee....................qaeaykkvleamngrpv 80 
                      +++++ + k+ + + v+aN+dt+ da+ka e+gaeGiGL+RtE++f++++++  +++                    q++++  +++am+g+ v
       EFC39103.1 603 FVRIMDIEKKYRTMSVYANADTSVDAHKAVEFGAEGIGLCRTEHMFFEKTRIVDMRRmivasttekrqeainvlkdyQRSDFLSLFHAMEGKKV 696
                      5667778888999**************************************9999999************************************ PP

                      EEEXXXSSCCGGSGGC.....................HHHH.XSXGGGSSXTHHHHCCSHHHHHHHHHHHHHHCCCC......EEEEEESSXXS CS
  PEP-utilizers_C  81 vvRtlDiggdkelpel.....................keepeevNPmlGfRgirlglsepelfetqlrAllrasaag......kleimlPmvas 147
                      ++R+lD++ +++lpe                      +++++e+NPmlG+Rg+rlg++ pe++++q+ A+++a++ +       + im+P+v+s
       EFC39103.1 697 TIRLLDPPLHEFLPEDpqeieelalalgesvkdvtltVSQLKEKNPMLGHRGCRLGITFPEITQMQVEAIFEAAIDAthkgevVVDIMVPLVQS 790
                      ***************999*******************999**********************************94445666699********* PP

                      HHHHHHHHHHHHHHHHHHHHCTCTXX..TTXEEEEEEXSHHHHHTHHHHCTTSSEEEEXHHHHHHHHHTXXCCCHC..HHHH.......SXTTT CS
  PEP-utilizers_C 148 veeleeakkiieevkeelekegvkkk..kkvkvGiMiEvpsaalladklakevdFfSiGtNDLtQytlavdRdnee..vakl.......ydple 230
                      v+el ++k+iie+v++ l +++  +k   +++vG MiE+p+a+l+a++la  +dFfSiG+NDLtQ+t++ +Rd++   +++         dp+e
       EFC39103.1 791 VQELVNQKEIIEKVASSLFAKHEDRKylIHYRVGCMIETPRAVLMAKELAGVADFFSIGSNDLTQMTFGFSRDDSGkfLKYYlerdlieNDPFE 884
                      ******************99876544227899******************************************998866667889999***** PP

                      CHHCCCHHHHHHHHHHCC......XEEEEESCCCCSCCCHHHHHHCTXSEEEEXGGGHHHHHHHHHCT CS
  PEP-utilizers_C 231 pavlrlikevikaaeekg......lkvgiCGelagdpsavellvglGldelSmsaasvpaaraalaqv 292
                      +++ ++++++i+ + + g      l+vg+CGe++g++++v++l + Gl ++S+s++++p+ar  +aq 
       EFC39103.1 885 VLDTEGVGKIIQLTVQTGreakngLTVGLCGEHGGESHSVKFLYQCGLSYVSCSPYRIPIARLSAAQE 952
                      **************9999999999***************************************99986 PP

>> PPDK_N  Pyruvate phosphate dikinase, PEP/pyruvate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  156.1   0.0   9.5e-49   1.3e-45       2     221 ..      75     371 ..      74     378 .. 0.93
   2 !   40.4   0.2   1.5e-13   2.1e-10     272     326 ..     383     435 ..     375     437 .. 0.92

  Alignments for each domain:
  == domain 1  score: 156.1 bits;  conditional E-value: 9.5e-49
      PPDK_N   2 elvGGKganLaellneagipvPpgfaitadafrefleengleekideelkeldvddvdelrkaskeirelilsaelPeeleeaikeayeelgkkfgde. 99 
                 el+GGKganL e+  ++gi+vPpgf+++++a+++f +  +l++   ee +e                ++l l  ++  +++e +k++++++gkkf d+ 
  EFC39103.1  75 ELLGGKGANLCEM-CNLGINVPPGFTVSTEACEHFSQLHNLATSAGEEGAE---------------KKNLTLPENIQTQVDEYLKKLEQATGKKFTDSy 157
                 79***********.66*********************99999999887776...............466777888888888888888888888888876 PP

      PPDK_N 100 e......lpvaVRSSataEDlpkasfaGqqdtyLnvggeeevle....................................................... 137
                 e      l+++VRS+      +  s++G++dt+Ln+g  ++ +                                                        
  EFC39103.1 158 EndtdkvLLISVRSG------AAISMPGMMDTILNLGICDKNITqlvknfggnekfawdsyrslvqmfgevvmsvkpehfednikkqkekrgithdsel 250
                 24566669*******......99**************99999888****************************************************** PP

      PPDK_N 138 ...................................aikavfaSlfnerAilYrkekgldheevalavvvqkmvnsdlg...asGVafsldpetG...fk 195
                                                    ai avf+S+ n+rA+ Yrk ++++    ++av++q+mv++++     sGV+fs++p+tG   f 
  EFC39103.1 251 nleeiqqivqdhkltifeqtggedfpqdvrqqlyrAIIAVFNSWHNKRAVQYRKIHNIT-GLKGTAVNIQSMVFGNVDersCSGVCFSRNPSTGenlFY 348
                 ***********************************************************.99**************99********************* PP

      PPDK_N 196 devlinasyGlGeaVVaGrvtpdefv 221
                 +e++i+a   +Gea+VaG++tp+++ 
  EFC39103.1 349 GEYMIQA---QGEAIVAGQRTPEKIE 371
                 *******...************9985 PP

  == domain 2  score: 40.4 bits;  conditional E-value: 1.5e-13
      PPDK_N 272 eLaeiakkiekhygtpmdiEfaideeegklyllQaRpetrtsekkekkaaetlee 326
                  L+ei +k+ekh+++ +d+Ef+i+  +++ly+lQ+R++++t +++ k+  ++ +e
  EFC39103.1 383 SLKEISTKLEKHFKDVQDMEFTIE--QNTLYMLQCRNGKKTIQASLKIYCDMIDE 435
                 799*********************..*****************999988887766 PP

>> ADK  Adenylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  163.7   0.0   2.3e-51   3.2e-48       2     149 ..     964    1117 ..     963    1119 .. 0.97

  Alignments for each domain:
  == domain 1  score: 163.7 bits;  conditional E-value: 2.3e-51
                  EESTTSSHHHHHHHHHHHHTSEEEEHHHHHHHHHHCT-HHHHHHHHHHHTTSS--HHHHHHHHHHHHHCH.GTTTEEEEESB-SSHHHHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK    2 lGaPgaGKGtqaeklvkkyglahlstGdllRaevksgtelGkeakevmdkgelvpdevvvklvkeeleke.dkkkgfllDGfPRtveqaealeelle 97  
                   G+Pg+GKGtq++klv+kyg++h stGdllRae +++te+G+++++++++g++vp  v+++l+++++ ++ +k+  fl+DGfPR+++qa  +e+   
  EFC39103.1  964 NGGPGSGKGTQCAKLVEKYGFIHYSTGDLLRAEAAKDTEQGRMISSYIKEGKIVPGAVTLGLLRNAILNHpKKDATFLIDGFPREMQQAVDFEA--- 1057
                  69****************************************************************998879999*******************... PP

                  HHTSEESEEEEEE--HHHHHHHHHT.........GSHHHHHHHHHHHHHHHHHHHHHHHHT CS
                  xxxxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK   98 eekvkldlvleldvpeevlveRltg.........DneetvkkRletykkqtkplidyykkk 149 
                   + +k ++vl +d+pee+l +Rl++         Dn+e++kkR++ty++qt+p+i y+kk+
  EFC39103.1 1058 -HVCKFKFVLFFDCPEEILEQRLLErgktsgrsdDNAESIKKRFKTYSDQTMPVIGYFKKT 1117
                  .99********************************************************97 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.1       1.6   2.3e+03      43     106 ..     232     289 ..     216     298 .. 0.56
   2 !  115.3   0.0     2e-36   2.7e-33       2     136 .]     965    1097 ..     964    1097 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.6
                 HHHHCTSHHHHHHHHHHHHH.HHHHHHHHSSEEEEEE-SEEEETTEEEESSHHHHHHHH..SEEE CS
      AAA_17  43 rdemrklpleekkelqkeaa.ekiaeeakkkgvlvdghprikeqagfldglpkevleelkpdaii 106
                 +d+++k ++++   ++ e+  e+i      ++++ d + +i eq g  +++p++v ++l   +i 
  EFC39103.1 232 EDNIKKQKEKRGITHDSELNlEEI------QQIVQDHKLTIFEQTG-GEDFPQDVRQQLYRAIIA 289
                 444444444444444433320222......3455666677777777.578888888888444444 PP

  == domain 2  score: 115.3 bits;  conditional E-value: 2e-36
                  E-TTSSHHHHHHHHHHHHTEEEEEHHHHHHHHHHTT..TSHSSHHHHCTSHHHHHHHHHHHHHHHHHHHH.HSSEEEEEE-SEEEETTEEEESSHHH CS
      AAA_17    2 GgPGsGKgtqceklvekygfthlsaGdllreeakrg..glakardemrklpleekkelqkeaaekiaeea.kkkgvlvdghprikeqagfldglpke 95  
                  GgPGsGKgtqc+klvekygf h+s+Gdllr+ea+++  +  +  ++++++++++   ++ ++ ++i ++  k+ ++l+dg+pr    +++  +++++
  EFC39103.1  965 GGPGSGKGTQCAKLVEKYGFIHYSTGDLLRAEAAKDteQGRMISSYIKEGKIVPGAVTLGLLRNAILNHPkKDATFLIDGFPRE---MQQAVDFEAH 1058
                  9*****************************9998884334789999********************998636677*******94...4445789997 PP

                  HHHHH..SEEEEEE--HHHHHHHHHHH.TTST-TS-SHHHHH CS
      AAA_17   96 vleelkpdaiilleadpeeilerrlkd.rtrgrdddneesik 136 
                  v+   k ++++++++++e + +r+l++ +t+gr+ddn+esik
  EFC39103.1 1059 VC---KFKFVLFFDCPEEILEQRLLERgKTSGRSDDNAESIK 1097
                  65...557888888888877777777799***********97 PP

>> PEP-utilizers  PEP-utilising enzyme, mobile domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.5   0.2   1.5e-24     2e-21       5      73 .]     505     584 ..     501     584 .. 0.96

  Alignments for each domain:
  == domain 1  score: 75.5 bits;  conditional E-value: 1.5e-24
                    -EEEEES---HHHHTTS-GEEEEEES--TTHHHHHHHHHHTT--EEE--SSHH............HH--TEEEEEETTTT CS
  PEP-utilizers   5 gvILvaeetspsdiagldkaaGivterGGmtSHaAivArelgiPaVvgvgeati...........elkegdlitvDgstG 73 
                    +vILv+e+ts +d+ag+++ +G++t +GG tSHaA+v+r+ g+++V+g++ + +            +++gd+it+DgstG
     EFC39103.1 505 DVILVREQTSTEDLAGMHASQGFLTTNGGLTSHAAVVSRQQGKCCVSGCSLLYVtseesctingtLFNQGDIITIDGSTG 584
                    69**************************************************99**********888888*********9 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.3   0.0   2.5e-12   3.5e-09       1     125 [.     961    1094 ..     961    1099 .. 0.83

  Alignments for each domain:
  == domain 1  score: 37.3 bits;  conditional E-value: 2.5e-12
      AAA_18    1 IlltGtpGvGKttlakeLskrlgf.gvnlrdvakenglllevdpe....aldeskrldedkldklldaleenssaleegknlvidghlaeleseaak 92  
                  I+++G pG+GK t +  L ++ gf ++  +d+++ +   ++++       ++e k++   ++  ll++   n     +  + +idg++ e+ ++ ++
  EFC39103.1  961 ICVNGGPGSGKGTQCAKLVEKYGFiHYSTGDLLRAEAAKDTEQGRmissYIKEGKIVPGAVTLGLLRNAILNHP--KKDATFLIDGFPREMQQAVDF 1055
                  9********************98896666666666666666666677778999999999997666666655544..677788**********99999 PP

      AAA_18   93 dikk......vvLtaspeelleRlekRgyeeakikenee 125 
                  +++        + ++++e+l +Rl +Rg+++ +  +n e
  EFC39103.1 1056 EAHVckfkfvLFFDCPEEILEQRLLERGKTSGRSDDNAE 1094
                  99999***99999********************887766 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.56   7.7e+02     102     138 ..     222     260 ..     205     264 .. 0.80
   2 !   23.4   0.0   3.9e-08   5.4e-05       1     131 [.     960    1098 ..     960    1108 .. 0.72

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.56
      AAA_33 102 vvvetdeetlkeRlakRaang..ddrsevpeealdrqka 138
                 vv+++ +e  +++++k+++++  +++se+++e +++  +
  EFC39103.1 222 VVMSVKPEHFEDNIKKQKEKRgiTHDSELNLEEIQQIVQ 260
                 7888899999999999999887779999***99998765 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 3.9e-08
      AAA_33    1 lvllvGlpGsGKstlaerllkklgavllssdtlrrrlfgtdqqsktdytrvldrlyqilnelarkalsagrnvil.....datnls...rrerarfl 89  
                  ++ + G pGsGK t   +l++k g+++ s+ +l+r+ +++d ++ +  +    +  +i+ + +  +l   rn+il     dat+l    +re+++ +
  EFC39103.1  960 VICVNGGPGSGKGTQCAKLVEKYGFIHYSTGDLLRAEAAKDTEQGRMISSYI-KEGKIVPGAV--TLGLLRNAILnhpkkDATFLIdgfPREMQQAV 1053
                  67889***************************99988886666654322211.2333555555..35666888888888899998777789998777 PP

      AAA_33   90 kl.arrlgvpvrivvvetdeetlkeRlakRaang...ddrsevpee 131 
                   + a+ ++++  +++++++ee l++Rl +R +++   dd +e  ++
  EFC39103.1 1054 DFeAHVCKFK-FVLFFDCPEEILEQRLLERGKTSgrsDDNAESIKK 1098
                  7735545544.6799*****************98433344443333 PP

>> Thymidylate_kin  Thymidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   0.00033      0.46       2      52 ..     964    1016 ..     963    1031 .. 0.81
   2 !    6.6   0.3     0.004       5.5     119     184 ..    1063    1135 ..    1047    1136 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00033
                       EESTTSSHHHHHHHHHHHHHHTTE....EEEESSSTTSHHHHHHHHHHHTCS-- CS
  Thymidylate_kin    2 EGlDGaGKttqaellkerlkeegik...vvltrepggteiGekirelllkeeel 52  
                        G  G+GK tq+++l+e++   +++    ++    ++te G++i ++++ e ++
       EFC39103.1  964 NGGPGSGKGTQCAKLVEKYGFIHYStgdLLRAEAAKDTEQGRMISSYIK-EGKI 1016
                       6888**************9988888774455555789**********99.5555 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.004
                       SEEEEEESSHHHHHTSCCTTSS....TTTSHHHHHHHHHHHHHHHHHH...HHTTSTEEEEETTS-HHHHHHH CS
  Thymidylate_kin  119 dltflldvdpevalkRlakrde....ldeeeeeqldflrkvrerylel...akederiliidasksieevhee 184 
                        +++++d+++e+  +Rl +r++    +d++ e  ++ ++++  + + +   +k+++r+++id sk  eev +e
       EFC39103.1 1063 KFVLFFDCPEEILEQRLLERGKtsgrSDDNAESIKKRFKTYSDQTMPVigyFKKTDRVKTIDSSKTQEEVFAE 1135
                       5799****************99877533333333333444444433331115678899999999999999776 PP

>> HpcH_HpaI  HpcH/HpaI aldolase/citrate lyase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   9.6e-06     0.013      87     171 ..     782     871 ..     764     913 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 9.6e-06
                 EEEESS--SHHHHHHHHHHTSHTTTS---......HCCC-EEEEEE-SHHHHHTHHHHHTSTTEEEEEE-HHHHH.HHTT-TTSTTSHHHHH CS
   HpcH_HpaI  87 vvlvPkvetaeealevvsalrepekgirg......anketrllaqiEsaegvknaeeIaavegldgvflGaeDls.adlgtkrspegtevld 171
                  ++vP v++ +e+++ +++++++            +  + r+ + iE+ ++v+ a+e a v   d   +G++Dl+ ++ g +r+++g+ + +
  EFC39103.1 782 DIMVPLVQSVQELVNQKEIIEKVASSLFAkhedrkYLIHYRVGCMIETPRAVLMAKELAGVA--DFFSIGSNDLTqMTFGFSRDDSGKFLKY 871
                 58********99999988888866333223443339999********************886..77889*****747899999988876664 PP

>> HTH_48  HTH domain in Mos1 transposase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0    0.0042       5.8      16      36 ..     206     226 ..     204     230 .. 0.90
   2 ?   -3.6   0.0       9.4   1.3e+04      16      31 ..     306     325 ..     301     331 .. 0.61
   3 ?    4.8   0.0     0.023        32       9      38 ..     413     442 ..     410     443 .. 0.68

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0042
      HTH_48  16 ksaaeahrkickvygedvlse 36 
                 k a +++r +++++ge+v+s 
  EFC39103.1 206 KFAWDSYRSLVQMFGEVVMSV 226
                 78999**************96 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 9.4
      HTH_48  16 ksa...aeahrkickv.yge 31 
                 +++   + ++ +i ++ +g+
  EFC39103.1 306 HNItglKGTAVNIQSMvFGN 325
                 55555567888996662686 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.023
      HTH_48   9 Lyefkkgksaaeahrki.ckvygedvlsert 38 
                 L + + gk+  +a  ki c+++ e+ ++er+
  EFC39103.1 413 LQC-RNGKKTIQASLKIyCDMIDEGLINERE 442
                 444.45555555555555**********997 PP

>> RB_A  Retinoblastoma-associated protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.1      0.54   7.5e+02       4      64 ..     102     163 ..      99     175 .. 0.71
   2 ?   12.4   0.3   7.6e-05       0.1      20     109 ..     365     452 ..     357     458 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.54
        RB_A   4 saavetvsqLrellsslsdep.sekLlelfksctedpteeiekrvkelsekflkkyaessee 64 
                 ++a+e  sqL++l +s+ +e  ++k l+l +++++++ e ++k  +  ++kf ++y++++++
  EFC39103.1 102 TEACEHFSQLHNLATSAGEEGaEKKNLTLPENIQTQVDEYLKKLEQATGKKFTDSYENDTDK 163
                 68889999999999998877645555566677777776666666667777777777766655 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 7.6e-05
        RB_A  20 lsdepsekLlelfksctedpteeiekrvkelsekflk.kyaesseeeessslaeelakkrlklaekLYykvLesilksEkkrlsskdlskl 109
                 +++e  e+L + f +c+++  +ei ++++++ + +++ +++ ++++    +l+ + +kk+++ ++k+Y+ ++++ l +E++ +s+ d+++l
  EFC39103.1 365 RTPEKIETLATNFPECNTSL-KEISTKLEKHFKDVQDmEFTIEQNT--LYMLQCRNGKKTIQASLKIYCDMIDEGLINEREAISKIDATQL 452
                 45677899********9996.89************98445544444..59999999*************************9999988776 PP

>> DUF4142  Domain of unknown function (DUF4142)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.5   4.5e-05     0.063      53      93 ..     121     159 ..     106     163 .. 0.85
   2 ?   -3.6   0.0       8.8   1.2e+04     116     138 ..     378     400 ..     354     401 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 4.5e-05
     DUF4142  53 alaskkgvtlpdsteldaeaqakldkLkalsgaaFDkaYle 93 
                 + a+kk++tlp  ++++++ ++ l+kL++++g++F + Y +
  EFC39103.1 121 EGAEKKNLTLP--ENIQTQVDEYLKKLEQATGKKFTDSYEN 159
                 5689*******..69**********************9965 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 8.8
     DUF4142 116 aelkafaektlptlqaHleeaea 138
                 +e  + +++  ++l++H + +++
  EFC39103.1 378 PECNTSLKEISTKLEKHFKDVQD 400
                 66667778888888888888776 PP

>> Cytidylate_kin  Cytidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00044      0.61       1      37 [.     961     997 ..     961    1018 .. 0.91
   2 ?   -0.7   0.0      0.72   9.9e+02     136     208 ..    1068    1139 ..    1030    1141 .] 0.68

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00044
                     EEEE-STTSSHHHHHHHHHHHHT-EEEEHHHHHHHHH CS
  Cytidylate_kin   1 iaiDGPagsGKssvaralaeklglkyldtgalYRala 37 
                     i + G  gsGK++ + +l ek g+   +tg l Ra a
      EFC39103.1 961 ICVNGGPGSGKGTQCAKLVEKYGFIHYSTGDLLRAEA 997
                     6789999**************************9876 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.72
                      EE--HHHHHHHHHHHHHHTT--.--HHHHHHHHHHHHHHHHCTSSS-S---TT-EEEETTTS-HHHHHHHHHHH CS
  Cytidylate_kin  136 ldAsveeRakRRlkqlkakgts.vsleellaeikeRDklDkerevgpLklaedaliidtskltieevvekilel 208 
                       d   e+  +R l+  k++g s ++ e++ ++ k     D++  v +  + +d +    s++t eev +++ +l
      EFC39103.1 1068 FDCPEEILEQRLLERGKTSGRSdDNAESIKKRFKT--YSDQTMPVIGYFKKTDRVKTIDSSKTQEEVFAEVCKL 1139
                      55555555555555555566664455555555443..4688888877777777776666678999999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1141 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       847  (0.0472419); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.86u 0.34s 00:00:01.20 Elapsed: 00:00:00.52
# Mc/sec: 6605.94
//
Query:       EFC39104.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.024   14.6   0.1      0.057   13.4   0.1    1.7  1  CE2_N     Carbohydrate esterase 2 N-terminal
      0.057   13.9   1.1       0.23   11.9   0.0    2.7  4  SAM_1     SAM domain (Sterile alpha motif)


Domain annotation for each model (and alignments):
>> CE2_N  Carbohydrate esterase 2 N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   6.4e-06     0.057      31     102 ..     114     184 ..     108     189 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 6.4e-06
                 EEEEEEE..SSS-EEEEEEETTS--EEEEE-SS-EEEEEEEEEEEEEEEEEEEE-S-GGG--EEEEEEEEE. CS
       CE2_N  31 lsvrlkdkedkgknrlaviiDgkrvkdlkldgeektytlaeglepgehtvrlvkrtEaeagkteflgfvlde 102
                 l +r+++ +++ + +++v+iD+k+ k+   +++ +t+ + e+++p++++  ++k  E +  +te+ + vl++
  EFC39104.1 114 LGIRVDN-KTNMDLEMQVFIDEKKMKSRCCERNAETFIISERSNPQTVHPFILKKHEQAEDETEIDKEVLKK 184
                 5567777.7788889*********999999999999***************************998877765 PP

>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0      0.94   8.5e+03      39      49 ..      44      55 ..      40      59 .. 0.76
   2 ?   -3.4   0.0       1.6   1.4e+04      23      43 ..      85     105 ..      84     106 .. 0.76
   3 ?   -3.1   0.0       1.3   1.1e+04      36      46 ..     176     186 ..     169     187 .. 0.83
   4 ?   11.9   0.0   2.5e-05      0.23      22      62 ..     359     400 ..     334     402 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.94
                HHHHHH.CTTTS CS
       SAM_1 39 eddLek.lgvtl 49
                 ++L+k +++tl
  EFC39104.1 44 IEELRKlINITL 55
                689999999998 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.6
                 HHHTTTSSHHHHTTSCHHHHH CS
       SAM_1  23 lFrageidgdaLlllteddLe 43 
                 lF+++   ++++ ++t+ dL 
  EFC39104.1  85 LFESNSRLVRKVSHITDFDLS 105
                 577777778899999988875 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.3
                 TSCHHHHHHCT CS
       SAM_1  36 llteddLeklg 46 
                 ++++++L+klg
  EFC39104.1 176 EIDKEVLKKLG 186
                 67888899887 PP

  == domain 4  score: 11.9 bits;  conditional E-value: 2.5e-05
                 HHHHTTTSSHHHHTTSCHHH..HHHCTTTSHHHHHHHHHHHHH CS
       SAM_1  22 dlFrageidgdaLllltedd..LeklgvtllGHrkkIlyaIqr 62 
                  lF+++ei+g+a+l l +++  +++lg  ++G r kI + I++
  EFC39104.1 359 TLFKEHEINGRAFLSLPSSTssMLALGL-KIGSRAKIEQIIKQ 400
                 467*************999999****99.78******999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1295  (0.0722293); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.51
# Mc/sec: 2396.16
//
Query:       EFC39105.1  [L=660]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.15   10.1  75.5       0.09   10.9   0.5    2.4  2  AF-4      AF-4 proto-oncoprotein
        1.7    6.8  15.1       0.15   10.2   9.3    2.1  2  SSP160    Special lobe-specific silk protein SSP160


Domain annotation for each model (and alignments):
>> AF-4  AF-4 proto-oncoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1  68.8    0.0022        20     531     820 ..     171     452 ..      87     489 .. 0.61
   2 ?   10.9   0.5     1e-05      0.09    1085    1133 ..     535     586 ..     533     600 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.0022
        AF-4 531 sqeessaessseteesespkkeskeqsqgkskssssevveesseskpkakskaeqkkseekqdkrskqkspaqkeseepntrktvgkkqPkksekasve 629
                 ++  s++++ss+t++s +++++++   ++ ++s+ +  + e+++ +   k+  +qk+++ +q+k+ k    + ++++e +++++v +++Pkk++k+s +
  EFC39105.1 171 TSTTSKTTNSSTTSNSINSTNHTSAAVTSVKSSNGTTTTFEPKNNQVGLKTLLAQKQQQMQQQKEDK--METDEKTKEDKKEEKVKEEKPKKTTKTSKK 267
                 1111111112222221111111111111111212222222223333333444444444444344444..44445777888888***********96555 PP

        AF-4 630 eepksslkvekevpveekdqsskdrpkvktkgrrktaprkepksslrlasekkkkrssskkaapksrefveteksesesdseellplsplkqsqtpsss 728
                 + +k+    e+e   e++++ s ++p  ktk  +k + +k  k+++   ++k+ k++ ++k ++k++ + et+k+   s+++ ++p+++     t  +s
  EFC39105.1 268 K-SKKDSDSESEYVDESESDESDKKPSKKTK--KKEKIKKPTKPKT---TKKETKKE-EEKKETKKETKKETKKETRSSKKDITIPSPKR----TLDPS 355
                 5.57788899997788888888899999997..4444555555555...33333333.33455577777777777666666666666664....44444 PP

        AF-4 729 essr.tsskkksevveekltkeklplpvrekkllsplrds.....eepqsLlVKIdLslLsrvPq.rpekesqskkaesksepeegkkkeskqkskkss 820
                  s++ t++ +++++ ++k t++ +  p+  + + +p+ ++      +++s +VK  L+   r  q rp+++  +kk e+k++  +++k++++ k k+++
  EFC39105.1 356 GSENeTNGGDEPKSKKNKITSSIIDEPITATITTKPSVETisapvVKTTSQIVKEKLEA--RKSQtRPNEDPPKKKSETKQTLAKKQKHTADDKMKQKK 452
                 44433666666666666777666777777777777776665554556677888888874..55554566656666666665555555554444444222 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 1e-05
        AF-4 1085 FrlKkdtAlKYSrtLtehfk....nsskstqapspcvangkkstgtPSPlsps 1133
                  F+lK +t +KY   L+   +     s  ++q+ sp v++ ++s +tPSP+ +s
  EFC39105.1  535 FKLKSETIVKYKNYLMAKVNelggASTGNSQSTSPAVTS-PQSVSTPSPIHSS 586 
                  9**************988765555899********9996.66*******8554 PP

>> SSP160  Special lobe-specific silk protein SSP160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   9.3   1.7e-05      0.15     121     318 ..     167     204 ..     152     334 .. 0.67
   2 ?   -0.9   0.3     0.039   3.5e+02     284     306 ..     559     581 ..     541     614 .. 0.60

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 1.7e-05
      SSP160 121 sttsssstt.ssnsttttsnstsssnstssgltssasvvslidtiawvyqdssvgiaylmvsilalfygqsvsappyadlgipalpantsgagvpqsvq 218
                 +tts+s+t+ ++ns+t tsns +s+n ts+ +ts                                                                 
  EFC39105.1 167 ATTSTSTTSkTTNSST-TSNSINSTNHTSAAVTSVK--------------------------------------------------------------- 201
                 2222222220122222.3333333333333333322............................................................... PP

      SSP160 219 ikaaiayvnvtiyfitltgqqfedlqgpvatdcgcpnttsvaplvleweailaalealasssasanstssststststttststtttnsttstnstsss 317
                                                                                                                  ss
  EFC39105.1 202 -------------------------------------------------------------------------------------------------SS 203
                 .................................................................................................22 PP

      SSP160 318 n 318
                 n
  EFC39105.1 204 N 204
                 2 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.039
      SSP160 284 nstssststststttststtttn 306
                  st +s+sts + t+ +s +t  
  EFC39105.1 559 ASTGNSQSTSPAVTSPQSVSTPS 581
                 34444444444444444333322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (660 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4151  (0.231524); expected 358.6 (0.02)
Passed bias filter:                      781  (0.0435607); expected 358.6 (0.02)
Passed Vit filter:                       473  (0.0263818); expected 17.9 (0.001)
Passed Fwd filter:                       150  (0.00836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 2.63u 0.46s 00:00:03.09 Elapsed: 00:00:00.73
# Mc/sec: 2715.82
//
Query:       EFC39106.1  [L=194]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-14   52.7   0.0    5.5e-14   51.7   0.0    1.6  1  zf-Nse    Zinc-finger of the MIZ type in Nse subunit
     0.0016   18.2   0.3     0.0031   17.2   0.3    1.6  1  zf-MIZ    MIZ/SP-RING zinc finger


Domain annotation for each model (and alignments):
>> zf-Nse  Zinc-finger of the MIZ type in Nse subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.7   0.0   6.1e-18   5.5e-14       1      57 []      95     154 ..      95     154 .. 0.90

  Alignments for each domain:
  == domain 1  score: 51.7 bits;  conditional E-value: 6.1e-18
                 SXXXXXS..SBXXSB-TTTSSB-SSEEEESSS--EEEHHHHHHHCTT.TS-EE-SCCC-S CS
      zf-Nse   1 delaiee..erislkCPltlqpfeePvtskkCpHvFEreaIlelikr.kktvkCPvagCs 57 
                 d++ai++  ++i+++CP t ++++ePv+skkC+Hv+E+   ++ +++     +CP++gC+
  EFC39106.1  95 DDVAISSkrSTIKTTCPWTGSNLQEPVQSKKCKHVYEKAVAFAKLRTgGGYFECPIIGCK 154
                 89999887799****************************9999996615789*******6 PP

>> zf-MIZ  MIZ/SP-RING zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.3   3.5e-07    0.0031       1      46 [.     106     150 ..     106     156 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 3.5e-07
                 EESB-TTTSSB-SSEEEETT--SS--EEHHHHHHHHHHS---B-TT CS
      zf-MIZ   1 vslkCplslsrikiPvrgekCkHlqCfdlesylelnertetWnCPv 46 
                 ++++Cp + s ++ Pv+++kCkH+    + ++ +l     + +CP+
  EFC39106.1 106 IKTTCPWTGSNLQEPVQSKKCKHVY-EKAVAFAKLRTGGGYFECPI 150
                 6889*******************84.34556666666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (194 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1837  (0.10246); expected 358.6 (0.02)
Passed bias filter:                      671  (0.0374254); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 1075.83
//
Query:       EFC39107.1  [L=190]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       513  (0.0286129); expected 358.6 (0.02)
Passed bias filter:                      305  (0.0170115); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1107.00
//
Query:       EFC39108.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1768  (0.0986112); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 1381.36
//
Query:       EFC39109.1  [L=558]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
          7    5.8  11.0       0.61    9.3   3.8    2.3  2  ORC6      Origin recognition complex subunit 6 (ORC6)


Domain annotation for each model (and alignments):
>> ORC6  Origin recognition complex subunit 6 (ORC6)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   3.8   3.4e-05      0.61      96     165 ..       5      80 ..       2     153 .. 0.68
   2 ?    0.3   0.7     0.018   3.2e+02     114     156 ..     446     483 ..     413     540 .. 0.41

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 3.4e-05
        ORC6  96 skspsspstdpkslrkqlfsTPtKsktlktalsa..sksssplkrrrklaneedgeeeeed.apswvstsir.....d 165
                 +  +s+++++++s+++q++s P K+k++  +     +ks+spl +    a+    ++  ++ + +++  +i      d
  EFC39109.1   5 N--QSKQKQQQQSTEEQQQSEPKKKKKKTDSKDNltPKSNSPLDPENVCAPNTTLTSRFPQtLSKKNIIDIYysmicD 80 
                 3..44555599*************99887776669********98888777766666644444433333333666663 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.018
        ORC6 114 fsTPtKsktlktalsa.sksssplkrrrklaneedgeeeeedap 156
                  +TP  +++l ++ls+ s+s  pl+      + + + ++++++p
  EFC39109.1 446 VTTPIADDALLQPLSLdSSSLPPLS------FLLGSMNDNPSLP 483
                 3444444444444444322222222......1111122222211 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (558 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1779  (0.0992247); expected 358.6 (0.02)
Passed bias filter:                      797  (0.0444531); expected 358.6 (0.02)
Passed Vit filter:                       104  (0.00580066); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.30s 00:00:01.05 Elapsed: 00:00:00.49
# Mc/sec: 3438.82
//
Query:       EFC39110.1  [L=606]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (606 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       698  (0.0389313); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 3432.73
//
Query:       EFC39111.1  [L=423]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-40  136.8  15.5    3.8e-09   36.1   0.1    7.7  8  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.11   12.8   0.4       0.51   10.7   0.0    2.1  2  RNaseH_C  T4 RNase H, C terminal


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0   1.1e-05     0.096      10      40 ..      58      89 ..      54      92 .. 0.81
   2 !   22.9   0.1   5.9e-09   5.3e-05       2      41 ..      76     117 ..      76     122 .. 0.89
   3 !   15.5   0.2   1.2e-06     0.011       1      33 [.     102     135 ..     102     138 .. 0.90
   4 !    9.7   0.1   7.9e-05       0.7      20      38 ..     148     166 ..     145     166 .. 0.91
   5 !   36.1   0.1   4.2e-13   3.8e-09       1      46 [.     154     200 ..     154     204 .. 0.93
   6 !   25.1   0.1   1.2e-09   1.1e-05      17      49 .]     236     268 ..     202     268 .. 0.88
   7 !   27.5   0.4   2.2e-10   1.9e-06       1      38 [.     290     327 ..     290     328 .. 0.98
   8 !   35.2   0.0   8.2e-13   7.4e-09       1      42 [.     315     356 ..     315     361 .. 0.94

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.1e-05
     DUF4116 10 kkn.gsalkylseeLknDkeivlkAvkqngta 40
                ++n  + ++ +++eL   ke+++kAv+ +gt+
  EFC39111.1 58 DQNeEEFIESFPNELIGSKEFMKKAVEMCGTI 89
                555234677799*****************986 PP

  == domain 2  score: 22.9 bits;  conditional E-value: 5.9e-09
     DUF4116   2 rEivleavkkngsalky..lseeLknDkeivlkAvkqngtal 41 
                 +E++++av+ +g + +   l++e+ +D+++vl+Av++ +++l
  EFC39111.1  76 KEFMKKAVEMCGTIVRCecLNKEFLQDRDFVLRAVNNAPISL 117
                 7************9999888****************998654 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 1.2e-06
     DUF4116   1 DrEivleavkkng.salkylseeLknDkeivlkA 33 
                 Dr++vl av + + s l+ ++  ++nD eiv k 
  EFC39111.1 102 DRDFVLRAVNNAPiSLLEEIPLQYRNDDEIVFKS 135
                 9*********998578999************885 PP

  == domain 4  score: 9.7 bits;  conditional E-value: 7.9e-05
     DUF4116  20 seeLknDkeivlkAvkqng 38 
                 s++Lk+Dk ++lk +++++
  EFC39111.1 148 SDRLKSDKSFLLKVIENDP 166
                 9**************9986 PP

  == domain 5  score: 36.1 bits;  conditional E-value: 4.2e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng.talsyase 46 
                 D+ + l+++++++ ++k +s+eLk D +++++++ + g t ++y+++
  EFC39111.1 154 DKSFLLKVIENDPPIFKCISPELKTDTDFIMECLDRAGtTLFDYIPD 200
                 899***********************************556799996 PP

  == domain 6  score: 25.1 bits;  conditional E-value: 1.2e-09
     DUF4116  17 kylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + +  eL+nD+e++ +++k+ +ta s++s+++r
  EFC39111.1 236 HEVIIELSNDREFAYQCIKNQSTAASFFSPDIR 268
                 344567************************998 PP

  == domain 7  score: 27.5 bits;  conditional E-value: 2.2e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 DrE+ +e  + +  +++y ++eLkn+k +vl+ +++ng
  EFC39111.1 290 DREFLKEMYSLDIQNFHYMPDELKNNKTFVLELMEING 327
                 9************************************8 PP

  == domain 8  score: 35.2 bits;  conditional E-value: 8.2e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 ++ +vle++++ng+ l++ls++L+ D +i+ +A++qng++l+
  EFC39111.1 315 NKTFVLELMEINGLGLEFLSSSLRTDHDIIQRAIQQNGSSLN 356
                 577************************************997 PP

>> RNaseH_C  T4 RNase H, C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   5.7e-05      0.51      79     113 ..     195     230 ..     175     239 .. 0.84
   2 ?   -1.1   0.1      0.25   2.2e+03      63      89 ..     289     315 ..     264     321 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 5.7e-05
                 GGGS-HHHHHHHHHHHHT-----.TTHHHHHHHHTT CS
    RNaseH_C  79 fdyipeniadsiveqyesqklap.rskiysyfvkkk 113
                 fdyip+ i +siv+  +  k    +  i  yf+++ 
  EFC39111.1 195 FDYIPDWILESIVKDINILKSVSsKRFIRDYFARAA 230
                 9****************9997651556888999875 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.25
                 -HHHHHHHHHHHHHH-GGGS-HHHHHH CS
    RNaseH_C  63 teeeyarykenlklldfdyipeniads 89 
                  + e+ +    l + +f y+p+++ ++
  EFC39111.1 289 LDREFLKEMYSLDIQNFHYMPDELKNN 315
                 455555555566677888888887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (423 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       685  (0.0382063); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.34s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2513.96
//
Query:       EFC39112.1  [L=530]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.1e-07   29.5  11.9    1.4e-06   28.3  11.9    1.6  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3  11.9   7.8e-11   1.4e-06       2      39 ..      28      64 ..      27      65 .. 0.93

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 7.8e-11
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39
                +C++Cr+ + +Cd+  P+Cs+C ++  eC  y e++kr
  EFC39112.1 28 SCESCRRAHKRCDRLLPSCSKCLSKKIECN-YVEPKKR 64
                8*****************************.7777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (530 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1189  (0.0663171); expected 358.6 (0.02)
Passed bias filter:                      609  (0.0339673); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.51
# Mc/sec: 3108.90
//
Query:       EFC39113.1  [L=326]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      6e-06   26.0   1.1       0.13   12.4   0.0    4.3  4  TPR_2            Tetratricopeptide repeat
     0.0022   17.7   6.5       0.27   11.1   0.0    4.2  6  TPR_1            Tetratricopeptide repeat
     0.0035   17.5   0.0      0.064   13.4   0.0    2.4  2  TPR_9            Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.017   15.3   1.0       0.37   11.0   0.0    2.7  2  Cnn_1N           Centrosomin N-terminal motif 1
      0.017   15.3  10.3        4.9    7.6   0.6    4.8  5  TPR_8            Tetratricopeptide repeat
      0.087   13.2   0.0       0.12   12.7   0.0    1.4  1  AAA_16           AAA ATPase domain
       0.12   11.9   0.0       0.21   11.1   0.0    1.3  1  Gal-bind_lectin  Galactoside-binding lectin


Domain annotation for each model (and alignments):
>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0   5.2e-05      0.13       2      33 ..      98     129 ..      97     130 .. 0.95
   2 ?   -0.2   0.1      0.58   1.5e+03      17      33 ..     152     168 ..     144     169 .. 0.75
   3 !    6.8   0.0    0.0032       8.1      10      29 ..     184     203 ..     183     204 .. 0.89
   4 ?    1.5   0.0      0.16     4e+02       4      31 ..     225     253 ..     222     255 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 5.2e-05
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleldPn 33 
                 +al ++ ++y+ l +++ A +++ek+le++Pn
  EFC39113.1  98 DALIERSKCYEGLSEWKLASADLEKVLEIEPN 129
                 68999**************************8 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.58
       TPR_2  17 yeeAleafekAleldPn 33 
                  + A +++e+A e+  n
  EFC39113.1 152 VKLANNYLERAFEIVSN 168
                 56688899999988666 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0032
       TPR_2  10 ayyklgdyeeAleafekAle 29 
                 ++y+l ++e+A+ +  k ++
  EFC39113.1 184 ICYELEQFEKAISYATKGIK 203
                 689***********999876 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.16
       TPR_2   4 lynlGlayyklgdy.eeAleafekAleld 31 
                 l+++G +++ + +  e+ ++++e+Al+l+
  EFC39113.1 225 LCRRGSVLITKFKMiERGRQDLERALSLA 253
                 6666666666666668889999***9996 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       3.6   9.1e+03      28      34 .]      90      96 ..      90      96 .. 0.89
   2 !   11.1   0.0   0.00011      0.27      10      33 ..     106     129 ..      98     130 .. 0.94
   3 !    6.9   0.1    0.0022       5.7      10      29 ..     184     203 ..     183     204 .. 0.89
   4 ?   -3.5   0.0       4.5   1.1e+04       1      10 [.     222     231 ..     222     232 .. 0.76
   5 ?   -0.6   0.0      0.53   1.4e+03      22      31 ..     244     253 ..     237     255 .. 0.81
   6 ?   -1.7   0.1       1.2     3e+03      11      30 ..     267     286 ..     266     289 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.6
                HHHSTTH CS
       TPR_1 28 LelnPnn 34
                Le nPn+
  EFC39113.1 90 LEFNPNF 96
                899**97 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00011
                 HHHHTT-HHHHHHHHHHHHHHSTT CS
       TPR_1  10 ayfklgkydeAleyyekALelnPn 33 
                 +y  l +++ A ++ ek+Le++Pn
  EFC39113.1 106 CYEGLSEWKLASADLEKVLEIEPN 129
                 99*********************8 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0022
                 HHHHTT-HHHHHHHHHHHHH CS
       TPR_1  10 ayfklgkydeAleyyekALe 29 
                 ++++l+++++A+ y  k ++
  EFC39113.1 184 ICYELEQFEKAISYATKGIK 203
                 789**********9998875 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 4.5
                 HHHHHHHHHH CS
       TPR_1   1 akalynlGna 10 
                 a  l+++G +
  EFC39113.1 222 AALLCRRGSV 231
                 5679999976 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 0.53
                 HHHHHHHHHS CS
       TPR_1  22 eyyekALeln 31 
                 ++ e+AL+l 
  EFC39113.1 244 QDLERALSLA 253
                 7999***996 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 1.2
                 HHHTT-HHHHHHHHHHHHHH CS
       TPR_1  11 yfklgkydeAleyyekALel 30 
                 + +l+++d   e y+ + el
  EFC39113.1 267 FKYLKNHDLVMETYNLVKEL 286
                 56899999999999877666 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.0   2.5e-05     0.064      21      66 ..      89     134 ..      78     140 .. 0.89
   2 ?    1.2   0.0      0.16   4.2e+02      46      59 ..     240     253 ..     220     263 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 2.5e-05
       TPR_9  21 llllaPddpeerrdRGlllaqlGclsaAladLeaylalapdapdae 66 
                 ll ++P+  + + +R  +++ l  ++ A adLe  l+++p+++d+ 
  EFC39113.1  89 LLEFNPNFTDALIERSKCYEGLSEWKLASADLEKVLEIEPNRDDIV 134
                 89999***********************************999875 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.16
       TPR_9  46 saAladLeaylala 59 
                 + +++dLe++l+la
  EFC39113.1 240 ERGRQDLERALSLA 253
                 67899999999876 PP

>> Cnn_1N  Centrosomin N-terminal motif 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00014      0.37      12      60 ..     145     196 ..     144     208 .. 0.71
   2 ?    1.5   0.5      0.13   3.3e+02      16      39 ..     272     295 ..     269     302 .. 0.53

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00014
      Cnn_1N  12 LkKENFdLKLriyfLeerleklse...eqkeellkenielkveveslqkelk 60 
                 ++KEN++ KL  ++Le ++e  s+   +   +  +++  ++ e+e+ +k + 
  EFC39113.1 145 IQKENYNVKLANNYLERAFEIVSNnavQVPFSYYRSLYSICYELEQFEKAIS 196
                 79****************9988885554445556666666666666666655 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.13
      Cnn_1N  16 NFdLKLriyfLeerleklseeqke 39 
                 N dL ++ y L ++lek+++++ e
  EFC39113.1 272 NHDLVMETYNLVKELEKKETRTDE 295
                 444445555555555555554444 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0046        12       3      33 ..      99     129 ..      97     130 .. 0.82
   2 ?   -1.9   0.1       2.1   5.5e+03      20      29 ..     155     164 ..     143     165 .. 0.60
   3 ?    7.6   0.6    0.0019       4.9       4      29 ..     177     203 ..     176     207 .. 0.84
   4 ?    3.3   0.0     0.046   1.2e+02       3      32 ..     224     254 ..     222     256 .. 0.84
   5 ?    1.0   0.1      0.26   6.6e+02       6      33 ..     262     289 ..     257     290 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0046
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekaleldpd 33 
                 a+   +++y+ l + + A + +ek+le++p+
  EFC39113.1  99 ALIERSKCYEGLSEWKLASADLEKVLEIEPN 129
                 55666778888888899*************8 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 2.1
                 HHHHHHHHHH CS
       TPR_8  20 Akeyyekale 29 
                 A  y+e+a e
  EFC39113.1 155 ANNYLERAFE 164
                 4456777766 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0019
                 HHHHH.HHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   4 yynlg.siylklgdyeeAkeyyekale 29 
                 yy+   si+ +l+++e+A++y  k ++
  EFC39113.1 177 YYRSLySICYELEQFEKAISYATKGIK 203
                 6666668999*************9997 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.046
                 HHHHHHHHH.HHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiy.lklgdyeeAkeyyekaleldp 32 
                 ++++ gs++  k + +e   + +e+al+l+ 
  EFC39113.1 224 LLCRRGSVLiTKFKMIERGRQDLERALSLAS 254
                 6788888887888899999*********986 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.26
                 HHHHHHHHTT-HHHHHHHHHHHHHHHHH CS
       TPR_8   6 nlgsiylklgdyeeAkeyyekaleldpd 33 
                 ++ +  + l++++  +e+y+ + el+++
  EFC39113.1 262 LMLDSFKYLKNHDLVMETYNLVKELEKK 289
                 666778899***********99999876 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   4.7e-05      0.12     108     163 ..     214     287 ..      99     293 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4.7e-05
      AAA_16 108 vpelagaea.................srllellkrllallsrderplvlvlDdlqwadeaslql.laaLlrlle 163
                 +++ a+++a                 +r ++ l r+l+l+s++ +plvl lD +  ++ ++l +  ++L+++le
  EFC39113.1 214 GSKEADDLAallcrrgsvlitkfkmiERGRQDLERALSLASSKYEPLVLMLDSFKYLKNHDLVMeTYNLVKELE 287
                 333333333566667777777888889***************************99999988887888877766 PP

>> Gal-bind_lectin  Galactoside-binding lectin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   8.1e-05      0.21      46     112 ..      89     178 ..      77     189 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 8.1e-05
                      EEEEEEETTTTEEEEEEEETTE..EEEEEE......................ESS-SSSTTSEEEEEEEEESSEEEEEETTEEEEEEE-S CS
  Gal-bind_lectin  46 iLhfnprfkgpvivrNscyrgq..Wgqeer.....................seksfpFaegklFeltirageegfhiavngrhvtsFpyr 112
                      +L fnp+f++  i+r+ cy+g   W+ +                         + +  +e+   +l+  + e+ f+i  n++  + F y 
       EFC39113.1  89 LLEFNPNFTDALIERSKCYEGLseWKLASAdlekvleiepnrddivshleqLYWFYIQKENYNVKLANNYLERAFEIVSNNAVQVPFSYY 178
                      699*****************9767987666678888888888888888854333333344444555556667888888888777777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (326 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       784  (0.043728); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1853.21
//
Query:       EFC39114.1  [L=342]
Description: EF-hand domain-containing transaldolase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.3e-64  218.3   0.1    2.3e-64  217.5   0.1    1.4  1  TAL_FSA    Transaldolase/Fructose-6-phosphate aldolase
      4e-12   44.7   4.4    1.9e-05   23.9   1.1    2.6  2  EF-hand_1  EF hand
    1.5e-11   44.6   2.5    1.5e-11   44.6   2.5    2.1  2  EF-hand_7  EF-hand domain pair
    1.2e-09   37.3   1.4    0.00087   19.0   0.1    2.9  2  EF-hand_6  EF-hand domain
    1.3e-08   34.5   2.6      8e-05   22.4   0.8    3.0  3  EF-hand_8  EF-hand domain pair
    9.6e-07   28.0   4.1     0.0061   16.0   0.6    2.7  2  EF-hand_5  EF hand
    0.00029   20.8   6.3        0.2   11.6   2.3    2.5  2  EF-hand_4  Cytoskeletal-regulatory complex EF hand
     0.0072   15.0   0.3      0.013   14.1   0.1    1.4  1  DUF853     Bacterial protein of unknown function (DUF853)
  ------ inclusion threshold ------
      0.026   14.8   0.3       0.13   12.6   0.2    2.3  2  EF-hand_9  EF-hand domain
        1.8    8.0   7.9       0.11   12.0   1.5    2.1  2  DUF1002    Protein of unknown function (DUF1002)


Domain annotation for each model (and alignments):
>> TAL_FSA  Transaldolase/Fructose-6-phosphate aldolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  217.5   0.1   1.3e-67   2.3e-64     107     285 ..       8     196 ..       1     198 [. 0.92

  Alignments for each domain:
  == domain 1  score: 217.5 bits;  conditional E-value: 1.3e-67
                 ..TEEEEEESSHHHHHHHHHHHHTT--EEEEEE-SHHHHHHHHHHT-SEEEEBHHHHHTTT.............S-HHHHHHHHHHHHHHHT-S-EEEE CS
     TAL_FSA 107 renvlIKiPateeGikAikeLkkeGinvnvTliFsleqalaaaeagasviSpFvgRiddll.kkleekdklkgkddgvalvkeiynyykklgysTkvma 204
                 +e+vl+Ki++t+eGi+A+k L+keGi++n+Tl+Fs  qa+a+aea++++iSpFvgRi+d++ ++++   +  ++d+gv +v++iyny+kk++y+T vma
  EFC39114.1   8 KERVLVKIASTWEGIEAAKVLEKEGIHCNLTLLFSKIQAIACAEANVTLISPFVGRILDYYvQNQKLVVSHPSQDPGVISVTSIYNYFKKYNYKTVVMA 106
                 78***********************************************************55555557778889************************ PP

                 BS--SHHHHHHHHT-SEEEE-HHHHHHHT--HHH........................................HHHHHHHHHHHHHHHH CS
     TAL_FSA 205 asfrnveeveelagcdtvTippkllealakhgkt......s.ekleeeeiek..lleklfrlginedavaeelldegikkFakdleklla 285
                 asfrnv e++el+gcd +T++p ll++la ++ +      s ek ++ ei k  l+eklfr+++neda+a+++l+ gi++F++dl kl++
  EFC39114.1 107 ASFRNVGEITELCGCDLLTVSPTLLKQLASTPCDelelklSeEKSKQVEITKveLSEKLFRWEMNEDACATDKLAGGIRSFTADLIKLEN 196
                 *******************************99989888843666668888899********************************9987 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.1   5.9e-08   0.00011       1      27 [.     208     234 ..     208     236 .. 0.93
   2 !   23.9   1.1     1e-08   1.9e-05       1      27 [.     250     276 ..     250     277 .. 0.91

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 5.9e-08
                 HHHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellk 27 
                 el+++Fr++DkDg+  +d +E kel+ 
  EFC39114.1 208 ELRKAFRLADKDGNNILDVNEVKELIY 234
                 79*********************9976 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 1e-08
                 HHHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellk 27 
                 e+ ++++++DkD+dG I+++Efke ++
  EFC39114.1 250 EVFQLMKLLDKDNDGNIEWDEFKETMQ 276
                 56789******************9985 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.6   2.5   8.4e-15   1.5e-11       2      71 .]     207     276 ..     206     276 .. 0.95
   2 ?   -0.9   0.2       1.3   2.4e+03      41      58 ..     297     318 ..     279     324 .. 0.64

  Alignments for each domain:
  == domain 1  score: 44.6 bits;  conditional E-value: 8.4e-15
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlklyr 71 
                 ++l+ aF++ D+dg++ ld++e+++l+ +++ ++     ++d+e+ +l+k +D+d+dG i +dEF++ ++
  EFC39114.1 207 SELRKAFRLADKDGNNILDVNEVKELIYNLKNSNVFIQQITDQEVFQLMKLLDKDNDGNIEWDEFKETMQ 276
                 7899**************************9999999999**************************9886 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.3
   EF-hand_7  41 lsd....eelellfkefDtdkd 58 
                 l +    ++++++f  f ++++
  EFC39114.1 297 LERdsvhDKVQKFFLQFRSNNN 318
                 3332222568888888877765 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.1   4.8e-07   0.00087       1      25 [.     208     232 ..     208     236 .. 0.92
   2 !   16.3   0.2   3.6e-06    0.0064       3      27 ..     252     276 ..     250     278 .. 0.87

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 4.8e-07
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrka 25 
                 elr+aF+l Dkdg++ +d +E++ +
  EFC39114.1 208 ELRKAFRLADKDGNNILDVNEVKEL 232
                 79********************986 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 3.6e-06
   EF-hand_6   3 reaFklfDkdgdGkidaeElrkalr 27 
                  ++ kl+Dkd+dG i ++E++  ++
  EFC39114.1 252 FQLMKLLDKDNDGNIEWDEFKETMQ 276
                 56779***************98775 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       1.7     3e+03      41      54 ..      84      97 ..      82      98 .. 0.84
   2 !   10.4   0.0   0.00026      0.47      22      51 ..     203     232 ..     188     236 .. 0.81
   3 !   22.4   0.8   4.5e-08     8e-05      20      53 ..     244     276 ..     235     277 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.7
   EF-hand_8 41 GkisfeEFcvller 54
                G+is ++ ++++++
  EFC39114.1 84 GVISVTSIYNYFKK 97
                88999999999987 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00026
   EF-hand_8  22 glseeevdilfrefDtdgdGkisfeEFcvl 51 
                  l e+e++  fr++D dg+++++ +E  +l
  EFC39114.1 203 ELQESELRKAFRLADKDGNNILDVNEVKEL 232
                 48899********************98765 PP

  == domain 3  score: 22.4 bits;  conditional E-value: 4.5e-08
   EF-hand_8  20 kkglseeevdilfrefDtdgdGkisfeEFcvlle 53 
                 + +++++ev  l++++D d+dG i ++EF + ++
  EFC39114.1 244 Q-QITDQEVFQLMKLLDKDNDGNIEWDEFKETMQ 276
                 3.39*************************98775 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   0.2   4.2e-05     0.075       1      24 [.     209     232 ..     209     233 .. 0.91
   2 !   16.0   0.6   3.4e-06    0.0061       5      23 ..     255     273 ..     252     275 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 4.2e-05
                 HHHHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIskeELktl 24 
                 l+++F+ +D++g   +++ E k+l
  EFC39114.1 209 LRKAFRLADKDGNNILDVNEVKEL 232
                 6889****************9886 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 3.4e-06
                 HHHH-SS-SSCE-HHHHHH CS
   EF-hand_5   5 FqaiDlNgDGkIskeELkt 23 
                  + +D+++DG I  +E+k+
  EFC39114.1 255 MKLLDKDNDGNIEWDEFKE 273
                 6789*************97 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.2    0.0002      0.36      34      77 ..     198     238 ..     185     242 .. 0.85
   2 !   11.6   2.3   0.00011       0.2      39      74 ..     245     280 ..     233     292 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0002
   EF-hand_4  34 vlknskleedklekiwdladidedgkldfeefciamrlifdlvn 77 
                 +l  s+l+e++l k + lad d ++ ld +e      li++l n
  EFC39114.1 198 ILYLSELQESELRKAFRLADKDGNNILDVNEV---KELIYNLKN 238
                 7888*************************995...456666665 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00011
   EF-hand_4  39 kleedklekiwdladidedgkldfeefciamrlifd 74 
                 +++++++ ++ +l d d+dg+++++ef  +m++  d
  EFC39114.1 245 QITDQEVFQLMKLLDKDNDGNIEWDEFKETMQIWID 280
                 677888899999********************9887 PP

>> DUF853  Bacterial protein of unknown function (DUF853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.1   7.2e-06     0.013     121     163 ..     198     240 ..     191     252 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 7.2e-06
      DUF853 121 llelndvqegvLnivfriadeeGllLldlkdLrallkevadna 163
                 +l l++ qe+ L  +fr+ad++G  +ld+ +++ l+ ++++  
  EFC39114.1 198 ILYLSELQESELRKAFRLADKDGNNILDVNEVKELIYNLKNSN 240
                 68899*****************************999987654 PP

>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       2.7   4.9e+03      11      26 ..      82      97 ..      80     101 .. 0.83
   2 ?   12.6   0.2   7.2e-05      0.13      30      66 .]     244     279 ..     211     279 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.7
   EF-hand_9 11 ktGrVpvsrlidyLra 26
                  G++ v+ + +y ++
  EFC39114.1 82 DPGVISVTSIYNYFKK 97
                5699******999875 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 7.2e-05
   EF-hand_9  30 qdpeeseLeelakelDPdgedasvdldtflrvmrewi 66 
                 q+ ++ e+ +l k+lD d+  + ++ d f++ m++wi
  EFC39114.1 244 QQITDQEVFQLMKLLDKDND-GNIEWDEFKETMQIWI 279
                 567899999*******9998.***************8 PP

>> DUF1002  Protein of unknown function (DUF1002)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   1.5   6.1e-05      0.11     166     219 ..     221     276 ..     201     278 .. 0.85
   2 ?   -1.5   0.6      0.82   1.5e+03     173     199 ..     305     332 ..     291     339 .. 0.61

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 6.1e-05
     DUF1002 166 eklkteeeikkiveevanelnin..lsdeqiqqivnllkkiqkldldlkelkkqlk 219
                 +++ + +e+k+++ +  n++     ++d+++ q+++ll+k ++ +++++e+k++++
  EFC39114.1 221 NNILDVNEVKELIYNLKNSNVFIqqITDQEVFQLMKLLDKDNDGNIEWDEFKETMQ 276
                 6788999******998776543347***************************9986 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.82
     DUF1002 173 eikkiveevanelnin.lsdeqiqqivn 199
                 +++k   +  +++ni+ ++++  ++i+n
  EFC39114.1 305 KVQKFFLQFRSNNNIDdINNNMNNNITN 332
                 4555555555555555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1052  (0.0586759); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 1971.99
//
Query:       EFC39115.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-39  135.8   0.5    5.1e-39  134.2   0.5    1.7  1  Pkinase         Protein kinase domain
    3.6e-24   85.4   0.2    7.7e-24   84.4   0.2    1.6  1  Pkinase_Tyr     Protein tyrosine kinase
    6.5e-09   35.1   2.5    1.8e-08   33.6   2.4    1.8  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.029   14.3   0.0      0.049   13.5   0.0    1.3  1  APH             Phosphotransferase enzyme family
        2.1    7.9  10.1       0.37   10.3   6.0    1.8  2  Lin-8           Ras-mediated vulval-induction antagonist


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  134.2   0.5   1.4e-42   5.1e-39       1     260 [.     200     500 ..     200     502 .. 0.83

  Alignments for each domain:
  == domain 1  score: 134.2 bits;  conditional E-value: 1.4e-42
                 EEEEEEEEEESSEEEEEEEETTTT.....EEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE..........SSEEEEEEE--TTEB CS
     Pkinase   1 yekleklGeGsfGkVykaveketg.....kivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee..........kdelylvleyvegge 84 
                 y++++ lG+G+fG V+k+ +  ++     ++ AvK i+  ++++ +  + lrE   l  l+h+n++++ +++            k+++++ +e++++g+
  EFC39115.1 200 YSNISLLGRGGFGAVFKCDKIIKKknappQTRAVKLIEFVSTDELN--RSLREAFRLCGLQHENVLKVHDAYVLqmgtsgslndKNTMCIEMEFIPCGD 296
                 677899***********96543331112267899*99999998876..59********************99988999****99999************ PP

                 HHHHHH.HHSS--HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEET.TTE......EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH..... CS
     Pkinase  85 ladlle.rkgslseeeakkiakqilegleylH.skgiiHrDlKpeNiLide.kge......lKitDFGlakelessskltsfvgtseYlAPEvl..... 169
                 la+ +  +k +ls e +k  ++ ++e+l yl+ +k+++HrD+Kp+Ni+i + +        + ++DFGlak +  s +  sf gt +Y++PE+      
  EFC39115.1 297 LAEKILkKKICLSCEILKTSLRCMCEALLYLYeEKQMVHRDIKPHNIMIRSmN-LenneldIVLGDFGLAKSVGDSASSASFAGTLQYMSPELFmmqqg 394
                 98776626666*********************5566*************9532.2356678********************************999999 PP

                 ...........TT.....SCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT..SHH...HHHTTS-HHHHHHHHHHT-SSGC CS
     Pkinase 170 ...........ke.....neyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..etkeklpeaseiseeakdllkkllkkdpk 250
                            ++     +++ +++D+++lGv++y+l++  +  s  +g   ++ + d+ +k++ +l+    k++++++ + +e++++l+ +++k+dp 
  EFC39115.1 395 mseeeqddqddQNdqetlRKHAHASDIFALGVTFYQLMSLDMNTS-ITGL-VMKFMGDE-KKLFTTLRekIAKNSSENNIQYDENFINLILNMVKRDPD 490
                 98887766555115566688999****************999999.3333.24444444.7788888756667777777888***************** PP

                 CSTTHHHHHT CS
     Pkinase 251 kRltaeellq 260
                 +Rl ae++l+
  EFC39115.1 491 ERLNAEQVLE 500
                 *******997 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.4   0.2   2.1e-27   7.7e-24       5     259 .]     204     502 ..     200     502 .. 0.85

  Alignments for each domain:
  == domain 1  score: 84.4 bits;  conditional E-value: 2.1e-27
                  EEEEEESSEEEEEEEEET.TTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE..........SSSSEEEEEE--TTEBHHHH CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkg.ekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct..........keepllivteyvkgGdLlkf 91 
                  + lG+G fG V+++     +k+   ++ avK + e  + +e ++ l+ea  ++ l+h+n++k++ +++          ++++++i +e+++ GdL + 
   EFC39115.1 204 SLLGRGGFGAVFKCDKIIkKKNAPPQTRAVKLI-EFVSTDELNRSLREAFRLCGLQHENVLKVHDAYVlqmgtsgslnDKNTMCIEMEFIPCGDLAEK 300
                  679***********87765788889999*****.556666699999*****************99988766655555444449999************ PP

                  HHHTCTTTSBHHHHHHHHHHHHHHHHHH.HHTTEEEST-SGGGEEEEE......TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE. CS
  Pkinase_Tyr  92 LrkkekekltlkdllsfalqvAkGmeyL.eskklvHrdlaarNvLlse......nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk. 181
                  + kk k  l+++ l      +++++ yL e+k++vHrd+   N+++++      +  + ++DfGLa+++    +  ++ +    +++m+pE ++ ++ 
   EFC39115.1 301 ILKK-KICLSCEILKTSLRCMCEALLYLyEEKQMVHRDIKPHNIMIRSmnlennELDIVLGDFGLAKSV---GDSASSASFAGTLQYMSPELFMMQQg 394
                  9999.9**********************56788**************8888876668999*********...566677888899********999989 PP

                  ....................EEHHHHHHHHHHHHHHHHTTSSGT......TTTS.HHHHHHHHHHT...TEES-BBTTSBHHHHHHHHHHT-SSGGGS CS
  Pkinase_Tyr 182 ....................ftsksDvWsfGvllwEiftlgesp......ypgl.kneevleklke...gkrlekpekcpeelyelmkkcweedpeeR 249
                                        ++sD+++ Gv+ + +++l  ++      ++ + ++++++++l+e   ++  e++ +  e++ +l+ +  ++dp+eR
   EFC39115.1 395 mseeeqddqddqndqetlrkHAHASDIFALGVTFYQLMSLDMNTsitglvMKFMgDEKKLFTTLREkiaKNSSENNIQYDENFINLILNMVKRDPDER 492
                  99****************9999*****************988877888875666566666666644111344566667889999************** PP

                  --HHHHHHHH CS
  Pkinase_Tyr 250 ptfselvekl 259
                   + ++++ekl
   EFC39115.1 493 LNAEQVLEKL 502
                  **99999876 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.6   2.4   5.1e-12   1.8e-08     233     387 ..     144     390 ..      23     404 .. 0.68

  Alignments for each domain:
  == domain 1  score: 33.6 bits;  conditional E-value: 5.1e-12
  Pkinase_fungal 233 frskrkvvsssssqelsskaevklkksesskkvekrsvdssv.stskrsr............................................. 281
                     +rs +++vs+ +  e s+ ++ ++++s+ss+  +++s+ +s  +++   +                                             
      EFC39115.1 144 VRSIDHSVSDFPMDEISTYSSKRSTNSNSSSGGNNNSTMTSFtQKT---Ktieelmqekysnisllgrggfgavfkcdkiikkknappqtravkl 235
                     3334444444444443333333333333333333333333332111...1234566777777888888888888888888888888888888888 PP

  Pkinase_fungal 282 ................................................lenrvhrrlvispvGkpiekae..spkelle.alrDaIkghrsLflk 325
                                                                     +    ++++   + +++i k +    +e+l+ +lr   +++  L+++
      EFC39115.1 236 iefvstdelnrslreafrlcglqhenvlkvhdayvlqmgtsgslndknTMCIEMEFIPCGDLAEKILKKKicLSCEILKtSLRCMCEALLYLYEE 330
                     888888888888888888888888888888888888888888855332222222333333444455444411234555425777789******** PP

  Pkinase_fungal 326 agiLHrDiSenNilitds.kkegerkglLiDLDlakelsddssesgarertGTleFmaievlk 387
                     ++++HrDi  +Ni+i     +++e   +L D+ lak+++d s++s      GTl++m+ e+ +
      EFC39115.1 331 KQMVHRDIKPHNIMIRSMnLENNELDIVLGDFGLAKSVGD-SASS--ASFAGTLQYMSPELFM 390
                     ****************8856669999*************7.4443..469********88766 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   1.4e-05     0.049     152     181 ..     317     346 ..     293     366 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.4e-05
                 HHHHHHHH--SSS-EEEE-SS-SGGGEEEC CS
         APH 152 vlaalaallpgelptvllHgDlhpgNllvd 181
                 ++ +++all   ++++ +H+D++p+N++++
  EFC39115.1 317 LRCMCEALLYLYEEKQMVHRDIKPHNIMIR 346
                 6677888888899***************99 PP

>> Lin-8  Ras-mediated vulval-induction antagonist
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   6.0    0.0001      0.37     182     292 ..      78     215 ..      18     225 .. 0.66
   2 ?   -1.7   0.1      0.48   1.7e+03     153     162 ..     399     408 ..     376     478 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.0001
       Lin-8 182 eaeevkeeqmeqsfe.....eeeeakleeptvniveeeaaaravdqsfgsaeqql.....................................essssrt 238
                 ++            +     ++++ ++++  vn+++++++++++++sf++++qq                                       s+ s+ 
  EFC39115.1  78 NNM-----------SitsnnNNNSFNNNNMSVNSFNNNNMNNNMNNSFNNNKQQSfdsfssgsggggdssfvmtnsmvrsidhsvsdfpmdeISTYSSK 165
                 112...........1223334555568888889999999999999999999888899999999999999999999999999999988865444444444 PP

       Lin-8 239 ssassssssaapsstaakdfeeemkqIteqakriareqPervkliRkaLfktvl 292
                 +s++s+sss  ++++ +++f+++    t+ ++ +++e+   ++l+ +  f +v+
  EFC39115.1 166 RSTNSNSSSGGNNNSTMTSFTQK----TKTIEELMQEKYSNISLLGRGGFGAVF 215
                 45555555555555556666655....566666777776666666666555555 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.48
       Lin-8 153 eegedteeee 162
                 e++++ ++++
  EFC39115.1 399 EQDDQDDQND 408
                 1111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2009  (0.112053); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.39s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 2799.78
//
Query:       EFC39116.1  [L=362]
Description: hypothetical protein NAEGRDRAFT_81382 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.7e-14   52.2  11.7    5.7e-14   52.2  11.7    2.8  2  OST3_OST6        OST3 / OST6 family, transporter family
    0.00041   20.3   0.5    0.00041   20.3   0.5    2.1  2  SpoIIIAH         SpoIIIAH-like protein
     0.0019   17.1   0.0       0.47    9.3   0.0    2.3  2  LptF_LptG        Lipopolysaccharide export system permease Lp
     0.0046   16.6   1.1     0.0046   16.6   1.1    2.5  2  DUF2370          Protein of unknown function (DUF2370)
     0.0073   16.1   1.3      0.083   12.6   0.5    2.2  2  Connexin         Connexin
  ------ inclusion threshold ------
      0.013   14.3   0.5      0.059   12.1   0.3    1.9  2  Ureide_permease  Ureide permease
      0.023   14.6   1.9       0.06   13.2   0.2    2.1  2  Kei1             Inositolphosphorylceramide synthase subunit 
      0.026   14.5   0.7        1.9    8.4   0.1    2.2  2  EOS1             N-glycosylation protein
      0.042   13.6   0.2       0.56    9.9   0.1    2.2  2  DUF3464          Photosynthesis affected mutant 68
      0.048   13.8   0.6        1.2    9.2   0.6    2.3  2  DUF4337          Domain of unknown function (DUF4337)
      0.059   11.8  17.1       0.12   10.7   5.4    2.0  2  Mpp10            Mpp10 protein
       0.22   10.9   7.2       0.11   11.8   3.3    2.1  2  DUF4746          Domain of unknown function (DUF4746)
       0.28   11.2   5.1        1.2    9.2   5.1    1.9  1  ORC_WH_C         Origin recognition complex winged helix C-te
        0.7   10.0  16.1        1.6    8.8   5.0    3.3  3  DHHC             DHHC palmitoyltransferase
          2    7.1  19.9       0.09   11.6   6.7    2.1  2  HCO3_cotransp    HCO3- transporter family
        2.6    7.4   8.5       0.34   10.2   3.2    1.9  2  DUF4820          Domain of unknown function (DUF4820)
        2.7    8.3   7.4         53    4.1   0.0    2.7  2  Peroxin-13_N     Peroxin 13, N-terminal region
        3.2    7.4   6.5       0.68    9.6   1.9    2.0  2  FAM176           FAM176 family
          4    7.5   5.1          6    6.9   1.0    2.1  2  RP-C_C           Replication protein C C-terminal region
        5.8    6.9  11.5        0.9    9.5   0.2    2.3  2  Jak1_Phl         Jak1 pleckstrin homology-like domain
        6.4    6.9  15.6      0.077   13.1   2.4    3.0  3  SPC12            Microsomal signal peptidase 12 kDa subunit (
        7.5    4.9  12.7      0.031   12.8   2.3    1.9  2  Cellulose_synt   Cellulose synthase
        8.4    6.6   8.7        8.9    6.5   1.9    3.2  3  Shisa            Wnt and FGF inhibitory regulator


Domain annotation for each model (and alignments):
>> OST3_OST6  OST3 / OST6 family, transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.2  11.7   7.2e-17   5.7e-14      44     258 ..       2     250 ..       1     268 [. 0.71
   2 ?    1.2   0.6      0.24   1.9e+02     123     173 ..     290     342 ..     260     360 .. 0.57

  Alignments for each domain:
  == domain 1  score: 52.2 bits;  conditional E-value: 7.2e-17
   OST3_OST6  44 fkCelCrefepefelvakswrkdekskskklfFakvdfdegkdvFqklglnsaPhlllfpp...................................... 104
                 ++C  C+  ++ +++ ++s++++      k + ++   +  + v qkl+l+++P + + +                                       
  EFC39116.1   2 HQCLHCKLYRDLLKKYVNSFTNE-----MKGILIEFTPQSQELVIQKLKLTHLPSVTIQSKytdqlydcnlkenqlwecvkdafkqsdhdlyenlkdfi 95 
                 57888888888888888888888.....35666666667788889999999999999988889999999999999999888888766666655544443 PP

   OST3_OST6 105 .kkgpkesk......kkdtydfsrggfdaealakfisertgvkirikrppnyskiiitallvlllvlllklrrklllkilksktlwavlslliillfts 196
                         +       k++++ s+++ + ++ ++  +++  ++ +++    +++i +++l+++++v+++  ++ l   +   ++++ +l++l+++l++s
  EFC39116.1  96 nM------DdikdlyLKYKNEYSSSSSNNQQQHNQQQNNHSNESPLFDFSSLKSITKIVLIAFCIVGFVIGISTLQNLLNGTRYMIFILCILTYILCMS 188
                 31......03434444444444444444444444444444455555555555555555555555555555544444333689***************** PP

   OST3_OST6 197 GymfnqIrgvpfvakdekgg.isyfaggsqnQfgaEtqivallygllallvilLiklvprikn 258
                 G++fn I+++p ++ +++++ is+f++++++ f++E++i  ++ ++ ++ +i++  +  ++ n
  EFC39116.1 189 GTVFNMIQNPPPYQYNPRENsISFFYPSMRMSFALEGYIATFVIVISSFYFIAIP-YYGYYDN 250
                 ********************9****************************999987.4444444 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.24
   OST3_OST6 123 gf.daealakfisertg.vkirikrppnyskiiitallvlllvlllklrrkll 173
                 +  + e + + ++e  + ++ ++k   +   +i  +++++ +++++++++ ++
  EFC39116.1 290 EVeEEEVVEEELNEEKKkEDSHYKSVLKRLFFIWGFFITFTAAMIFFMIKTSF 342
                 22356666667777777566666666666666677777777777777766655 PP

>> SpoIIIAH  SpoIIIAH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.4       0.4   3.1e+02      53      66 ..     114     127 ..      66     145 .. 0.59
   2 !   20.3   0.5   5.2e-07   0.00041       5      84 ..     231     310 ..     228     344 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.4
                 XXXXXXXXXXXXXX CS
    SpoIIIAH  53 essaasaeaessse 66 
                 +ss+++++ +++++
  EFC39116.1 114 SSSNNQQQHNQQQN 127
                 11111111111111 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 5.2e-07
                 XXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    SpoIIIAH   5 iitaLalmiavagYlnftedsgkkaaetaeteqeesekaeigddkekdessaasaeaesssetesesseksdiassdede 84 
                 +i+  +   +++ Y+ + +++++++++t + ++ +s+++++++ ++k++++++++++e++ e+e+  +e+ ++++++ed+
  EFC39116.1 231 VIVISSFYFIAIPYYGYYDNNNNTNNNTDNITTITSNTNNTKNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKKKEDS 310
                 55555677889999999999988777777766667777777775566666666666666666666666555555555554 PP

>> LptF_LptG  Lipopolysaccharide export system permease LptF/LptG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0    0.0006      0.47     251     314 ..     121     185 ..      17     200 .. 0.76
   2 !    5.8   0.0    0.0066       5.1     230     309 ..     275     359 ..     246     360 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.0006
   LptF_LptG 251 lkekikalrsegle.vrryraelhkrlalplaclvfaliaaplglvkrrggrglrlliaillfvl 314
                   ++++   s++ +  + + ++   ++ l  +c+v ++i+++  + +  g r++ ++++il ++l
  EFC39116.1 121 QHNQQQNNHSNESPlFDFSSLKSITKIVLIAFCIVGFVIGISTLQNLLNGTRYMIFILCILTYIL 185
                 2444555555555535555599999***********************************99987 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0066
   LptF_LptG 230 nldpadlsteeesp.....delslselkekikalrsegle.vrryraelhkrlalplaclvfaliaaplglvkrrggrglrlliai 309
                 n+++++ + +++++     +e+   el ++ k+ ++++++ v + +  ++  +    a+++f++i  ++ l+   + ++ +ll+ai
  EFC39116.1 275 NKKNKNKNGKKKNEeeveeEEVVEEEL-NEEKKKEDSHYKsVLKRLFFIWGFFITFTAAMIFFMIKTSFYLSDTPYHGWVQLLLAI 359
                 233333333333331111133333444.5666667777773555556777777777788999999999988888888888888887 PP

>> DUF2370  Protein of unknown function (DUF2370)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.028        22     170     212 ..     114     169 ..      65     179 .. 0.59
   2 !   16.6   1.1   5.9e-06    0.0046     122     214 ..     244     339 ..     237     345 .. 0.55

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.028
     DUF2370 170 aalsdlelaeeeknke..............sssewlayvlmilGlfiliksvvdylr 212
                 ++ ++ +++++++n +              s ++++ ++++i+G++i i+++ + l+
  EFC39116.1 114 SSSNNQQQHNQQQN-NhsnesplfdfsslkSITKIVLIAFCIVGFVIGISTLQNLLN 169
                 11111111111111.012344566666665777888888999999999998877665 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 5.9e-06
     DUF2370 122 qygfslrssaeeskvkkekeeg..rvepsdpnshdldkekvaekgekeeaaalsdlelaeeeknk.esssewlayvlmilGlfiliksvvdylrvk 214
                  yg++  ++++++++ + ++ +  + ++++ n+++ +k+ +++++e+ e++++ + el+ee+k++ ++ + +l  +++i G+fi+ ++ + ++ +k
  EFC39116.1 244 YYGYYDNNNNTNNNTDNITTITsnTNNTKNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKKKEdSHYKSVLKRLFFIWGFFITFTAAMIFFMIK 339
                 68888877777733332222221122233333333333333333333333333333333333333357788899999***********99999887 PP

>> Connexin  Connexin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0      0.18   1.4e+02     129     167 ..     112     150 ..      69     191 .. 0.61
   2 !   12.6   0.5   0.00011     0.083     107     172 ..     258     337 ..     224     351 .. 0.36

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.18
    Connexin 129 kkkkkeeekekkkeegkrrirggllrtYvlqlllrillE 167
                 +++++++++++++++++++ ++ l+ +  l+ +++i+l 
  EFC39116.1 112 SSSSSNNQQQHNQQQNNHSNESPLFDFSSLKSITKIVLI 150
                 112222222222222222225555555555555555543 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 0.00011
    Connexin 107 k.............eeeekeeeekeeekkkkkekkkkkkkeeekekkkeegkr.....rirggllrt.YvlqlllrillEvaflv 172
                 +             +     +++k++++k+ k+k++++ +eee  +++ ++++     + ++ l r+ +++  ++ ++  ++f +
  EFC39116.1 258 TdnittitsntnntK-----NTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKkkedsHYKSVLKRLfFIWGFFITFTAAMIFFM 337
                 134555555332221.....22222222222222222222222222222222200111223333222233333333333344444 PP

>> Ureide_permease  Ureide permease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.46   3.6e+02     129     157 ..     101     129 ..      87     194 .. 0.62
   2 ?   12.1   0.3   7.5e-05     0.059     117     219 ..     246     344 ..     218     354 .. 0.62

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.46
  Ureide_permease 129 keklskskseekeetkeeekkeeesekkk 157
                      k+   k+k+e+++++++++++++++++++
       EFC39116.1 101 KDLYLKYKNEYSSSSSNNQQQHNQQQNNH 129
                      44444444444443333333333222221 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 7.5e-05
  Ureide_permease 117 gsavhssnaadnkeklskskseekeetkeeekkeeesekkkeekdleegekaaekakagtaeflieleekraikvlgkstll.GlaivlfaGvc 209
                      g    + n+++n++++++++s++++++++++k+++++ kkk+e+++ee+e  +e++++  ++     e+     vl++  ++ G+ i++ a ++
       EFC39116.1 246 GYYDNNNNTNNNTDNITTITSNTNNTKNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKKK-----EDSHYKSVLKRLFFIwGFFITFTAAMI 334
                      44445667777888888888887777777776666666666666666666444444443332.....333333344444333377788877777 PP

  Ureide_permease 210 fslfspafnl 219
                      f +    f l
       EFC39116.1 335 FFMIKTSFYL 344
                      7777777666 PP

>> Kei1  Inositolphosphorylceramide synthase subunit Kei1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1       0.4   3.1e+02     129     170 ..     111     152 ..      77     162 .. 0.66
   2 ?   13.2   0.2   7.7e-05      0.06      42     139 ..     171     300 ..     136     344 .. 0.52

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.4
        Kei1 129 avssaasatsasvsaatssslasavlqqEsaasiiiivllll 170
                   ss+++++++++++++++s +s ++   s+ si+ ivl+ +
  EFC39116.1 111 YSSSSSNNQQQHNQQQNNHSNESPLFDFSSLKSITKIVLIAF 152
                 344555556666666666677777777777777777766654 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 7.7e-05
        Kei1  42 lqlsmylySllvlvllal..llphirke...............splkillla.vlYllDtvistaytvlFavdWflvleehdaaaaasta....gsasa 118
                 ++ ++ ++++l+ +l++   +++ i+++                p   +++a   Y++  vi + + ++ a+  + + ++++++++++++    +    
  EFC39116.1 171 TRYMIFILCILTYILCMSgtVFNMIQNPppyqynprensisffYPSMRMSFAlEGYIATFVIVISSFYFIAIPYYGYYDNNNNTNNNTDNittiT---- 265
                 44455555555544444311345666655566655555555553466677776677777777777777777777777666666666543333331.... PP

        Kei1 119 eatagatapa...............avssaasatsa 139
                  ++++ t+++               +v++++  +++
  EFC39116.1 266 -SNTNNTKNTnkknknkngkkkneeEVEEEEVVEEE 300
                 .22222222211122223332222222222222222 PP

>> EOS1  N-glycosylation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0     0.037        29     112     161 ..      88     157 ..      25     168 .. 0.63
   2 ?    8.4   0.1    0.0025       1.9      75     136 ..     225     298 ..     210     336 .. 0.47

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.037
        EOS1 112 l....................eskasslrqgksrhkrsvskseakkkrertsskrtldleeivvravvPv 161
                                      ++ +ss+++++++h++++++++++   +++ss +++   +++ +++v +
  EFC39116.1  88 YenlkdfinmddikdlylkykNEYSSSSSNNQQQHNQQQNNHSNESPLFDFSSLKSITKIVLIAFCIVGF 157
                 1444555555555555554432222222233333444444444466778899999998888888888854 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0025
        EOS1  75 sttltlseivqswvtSnladaeldsrevksrssaaerl...........eskasslrqgksrhkrsvsksea.k 136
                 ++++t++ +++s+    + +  + ++++++++++++ +           ++k+++ ++gk++++++v+++e  +
  EFC39116.1 225 GYIATFVIVISSFYFIAIPYYGYYDNNNNTNNNTDNITtitsntnntknTNKKNKNKNGKKKNEEEVEEEEVvE 298
                 45566666666666666655544433333322222222111111111112222222222222222222222232 PP

>> DUF3464  Photosynthesis affected mutant 68
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.38     3e+02      25      38 ..     114     128 ..      89     165 .. 0.60
   2 ?    9.9   0.1   0.00072      0.56      12      68 ..     272     324 ..     255     355 .. 0.41

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.38
     DUF3464  25 kkakkeek.ekakee 38 
                 + ++++++ ++++++
  EFC39116.1 114 SSSNNQQQhNQQQNN 128
                 111111111111111 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00072
     DUF3464  12 kkrkkkpkkkkkskkakkeekekakeeekkdkeekeeaaiPevVskRmirRvalfsG 68 
                 k+++kk+k+k+ +kk+++e +e++  ee+ ++e+k      +   k +++R+ ++ G
  EFC39116.1 272 KNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKK----KEDSHYKSVLKRLFFIWG 324
                 22222222222222222221111111222222222....223334444444444444 PP

>> DUF4337  Domain of unknown function (DUF4337)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0       0.2   1.6e+02      80     134 ..      98     153 ..      65     187 .. 0.72
   2 ?    9.2   0.6    0.0016       1.2      68     126 ..     266     338 ..     244     342 .. 0.67

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.2
     DUF4337  80 akykkkiarykke.kkeikkkAkeleaerdeaneasdkfdlasalLqiaIvlaaia 134
                 +++k+   +yk+e ++  +++ ++  ++ ++++ +s  fd +s+     Ivl a +
  EFC39116.1  98 DDIKDLYLKYKNEySSSSSNNQQQHNQQQNNHSNESPLFDFSSLKSITKIVLIAFC 153
                 56777777888884444455555566666666666777998887655556665555 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0016
     DUF4337  68 aeelaaavdkkiakykkkiarykkekkeikkkAkeleaerdeaneasdk..............fdlasalLqi 126
                 ++++++++++k++k k+  ++ ++e +e +   +el +e+++ + +++               f  a++++ i
  EFC39116.1 266 SNTNNTKNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKKKEDSHYKSvlkrlffiwgffitFTAAMIFFMI 338
                 3444445555666666666666666666666667777777777777777999999999999999999999977 PP

>> Mpp10  Mpp10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   3.8    0.0021       1.6      42     116 ..      55     130 ..      27     142 .. 0.69
   2 ?   10.7   5.4   0.00016      0.12     126     181 ..     260     320 ..     242     333 .. 0.34

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0021
       Mpp10  42 kkspLeelvvegfDeeqiWqqlelqneavleellkkiskllakkeklkl.ldeeeeeeseeseeeeeeeeeeeeee 116
                 +++  ++l+  ++ e+q W+ ++   ++  ++l +++++++++++  +l l+ ++e +s++s++++++++++++++
  EFC39116.1  55 QSKYTDQLYDCNLKENQLWECVKDAFKQSDHDLYENLKDFINMDDIKDLyLKYKNEYSSSSSNNQQQHNQQQNNHS 130
                 44457999999*******************************9854444444455444444333333333322222 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00016
       Mpp10 126 e......eeekeeseekeeeeesekeeeeededeeeeieeeekkskkkkkkkkkksvvddkF 181
                 +      +++++++++k+++++  k+++ee+ +eee +eee +++kk k++++ ksv    F
  EFC39116.1 260 NittitsNTNNTKNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKK-KEDSHYKSVLKRLF 320
                 11112111112222222222222222222222222222222222222.22244455555555 PP

>> DUF4746  Domain of unknown function (DUF4746)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1      0.49   3.8e+02      27      70 ..      12     112 ..       7     139 .. 0.37
   2 ?   11.8   3.3   0.00015      0.11      92     144 ..     263     313 ..     238     323 .. 0.55

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.49
     DUF4746  27 dvlkayahelteervkppdedneeekvl..........Ppl...............................................ieplevkveve 68 
                 d+lk+y+   t+e +  + e+ ++ + l          P +                                               i++l +k++ e
  EFC39116.1  12 DLLKKYVNSFTNEMKGILIEFTPQSQELviqklklthlPSVtiqskytdqlydcnlkenqlwecvkdafkqsdhdlyenlkdfinmddIKDLYLKYKNE 110
                 556666666666655555555554444423333333333332222222222222222222222222222222222222233333333334444444433 PP

     DUF4746  69 ee 70 
                   
  EFC39116.1 111 YS 112
                 33 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 0.00015
     DUF4746  92 ektkakeaeltade.paeeeeaeeeeeeeaveeeeeeeeeeeeeeedkeltktk 144
                 + t  +++++t+++ +++++++ ++++ee+veee e  eee +ee++ke  ++k
  EFC39116.1 263 TIT--SNTNNTKNTnKKNKNKNGKKKNEEEVEEE-EVVEEELNEEKKKEDSHYK 313
                 222..22333333336677777777777777777.4344444444444444443 PP

>> ORC_WH_C  Origin recognition complex winged helix C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.2   5.1    0.0016       1.2      41     106 ..      87     294 ..      60     320 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0016
    ORC_WH_C  41 lyleagrliN...vyDwyeaFkqvlekereedkeseaeeeekak....................................................... 81 
                 ly++   +iN   + D+y  +k+  +++++++++++++++++++                                                       
  EFC39116.1  87 LYENLKDFINmddIKDLYLKYKNEYSSSSSNNQQQHNQQQNNHSnesplfdfsslksitkivliafcivgfvigistlqnllngtrymifilciltyil 185
                 55555555552227899******999988877777776666666899**************************************************** PP

    ORC_WH_C  82 .........................................................................................eeeaekkkkk 91 
                                                                                                          +     kk+k
  EFC39116.1 186 cmsgtvfnmiqnpppyqynprensisffypsmrmsfalegyiatfvivissfyfiaipyygyydnnnntnnntdnittitsntnntkntN-----KKNK 279
                 *******************************************************************************99997554442.....2222 PP

    ORC_WH_C  92 kekeedeedeeewek 106
                 +++ +++++ee +e+
  EFC39116.1 280 NKNGKKKNEEEVEEE 294
                 222222332333332 PP

>> DHHC  DHHC palmitoyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.1     0.071        55      76     113 ..     126     163 ..     103     172 .. 0.66
   2 ?    8.8   5.0     0.002       1.6      49     125 ..     171     257 ..     166     277 .. 0.73
   3 ?    3.5   1.5     0.094        73      93     119 ..     304     343 ..     258     354 .. 0.58

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.071
        DHHC  76 lveeekkseflavtllkkllsilllvlsllfllllgll 113
                 + +++++s    ++ lk++++i+l++++++ +++ ++ 
  EFC39116.1 126 QNNHSNESPLFDFSSLKSITKIVLIAFCIVGFVIGIST 163
                 33344444444444444499999999998888776554 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.002
        DHHC  49 kyFllfllylllllilalvlllialvklveeekkseflavtllkk..........llsilllvlsllfllllgllllfhlylilrnl 125
                   +++f+l++l++++ +  + + ++++  +++++ +++ ++ ++           +++ +++v+s ++++ + +  ++   +  +n 
  EFC39116.1 171 TRYMIFILCILTYILCMSGTVFNMIQNPPPYQYNPRENSISFFYPsmrmsfalegYIATFVIVISSFYFIAIPYYGYYDNNNNTNNN 257
                 5699*******************************9999998887777777777756666666666666655555555333333332 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.094
        DHHC  93 k.............llsilllvlsllfllllgllllfhly 119
                 +              l +++ ++ ++ ++++++++++++y
  EFC39116.1 304 EkkkedshyksvlkRLFFIWGFFITFTAAMIFFMIKTSFY 343
                 0333333333311133344444444444444444444444 PP

>> HCO3_cotransp  HCO3- transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   5.3      0.15   1.2e+02     142     291 ..      15     187 ..      11     200 .. 0.47
   2 ?   11.6   6.7   0.00012      0.09     174     273 ..     248     346 ..     210     349 .. 0.56

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.15
  HCO3_cotransp 142 vkyitrfteeifallIslifiy.ealkkllkifkkyplnlklk.ellkkkcecsepek.....eeltesalekseeks.................. 212
                     ky+  ft+e+  +lI +     e + + lk+++   ++ + k + + ++c+ +e++      +     a ++s++                    
     EFC39116.1  15 KKYVNSFTNEMKGILIEFTPQSqELVIQKLKLTHLPSVTIQSKyTDQLYDCNLKENQLwecvkD-----AFKQSDHDLyenlkdfinmddikdlyl 105
                    5788888888888888766443133334444444444444444334556666666655444331.....222222222334446667777777866 PP

  HCO3_cotransp 213 ..elswsslltkkecteelkgelvgkecelvpdvallsli..LflgtfllalfLkkfkksrflptkvRelisDfavliailvm 291
                      + ++ss++++++++++++++ +++e +   d + l  i  ++l +f++  f+  + + + l +  R +i   ++l  il+m
     EFC39116.1 106 kyKNEYSSSSSNNQQQHNQQQNNHSNE-SPLFDFSSLKSItkIVLIAFCIVGFVIGISTLQNLLNGTRYMIFILCILTYILCM 187
                    553333333333332222222222222.2222333222221134444555555555555555555555555555555555555 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00012
  HCO3_cotransp 174 kkyplnlklkellkkkcecsepekeeltesalekseekselswsslltkke.cteelkgelvgkecelvp.dvallsliLflgtfllalfLkkfkk 267
                     ++  n+++ ++++++++++++++++++++++++++++ +++ ++ ++++e ++eel++e ++++ ++++  + l+++  f+ tf+ a+++  +k+
     EFC39116.1 248 YDN--NNNT-NNNTDNITTITSNTNNTKNTNKKNKNKNGKKKNEEEVEEEEvVEEELNEEKKKEDSHYKSvLKRLFFIWGFFITFTAAMIFFMIKT 340
                    222..1222.223334444444334444444444444444444444555553666666666666665444044577777899************** PP

  HCO3_cotransp 268 srflpt 273
                    s +l+ 
     EFC39116.1 341 SFYLSD 346
                    ***975 PP

>> DUF4820  Domain of unknown function (DUF4820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.2      0.83   6.5e+02     175     188 ..     115     128 ..      94     143 .. 0.50
   2 ?   10.2   3.2   0.00044      0.34     157     207 ..     254     304 ..     229     318 .. 0.53

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.83
     DUF4820 175 kesaesseskkrnk 188
                 ++++++++++++n+
  EFC39116.1 115 SSNNQQQHNQQQNN 128
                 11111111111111 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00044
     DUF4820 157 vsseldnsartlterksekesaesseskkrnkeerdaeseeessedeeeee 207
                 +++++dn ++++++ ++ k++++++++k+ +k+++++ +eee +e+e +ee
  EFC39116.1 254 TNNNTDNITTITSNTNNTKNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEE 304
                 444555533333333333333333333333444444444444444442222 PP

>> Peroxin-13_N  Peroxin 13, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.068        53      95     133 ..     109     153 ..      74     163 .. 0.49
   2 ?    3.8   4.9     0.082        64      88     136 ..     274     328 ..     227     337 .. 0.54

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.068
  Peroxin-13_N  95 eefwkkfessskkkeekeskeekkkkk.......isskplllflaa 133
                   +e+ +++++++++++++++++++++         +s   ++l++  
    EFC39116.1 109 NEYSSSSSNNQQQHNQQQNNHSNES-PlfdfsslKSITKIVLIAFC 153
                   2221222222212221111111111.12334223333334444444 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.082
  Peroxin-13_N  88 kkekskaeefwkkfessskkke......ekeskeekkkk.kisskplllflaavig 136
                    ++k+k+++ +kk e++ +++e      ++e k++++++ k+ +k l++++ ++i 
    EFC39116.1 274 TNKKNKNKNGKKKNEEEVEEEEvveeelNEE-KKKEDSHyKSVLKRLFFIWGFFIT 328
                   2222222222222222222222443222222.222222324666666666666665 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.2       1.3     1e+03      73      84 ..     116     127 ..      95     145 .. 0.48
   2 ?    9.6   1.9   0.00088      0.68      46      91 ..     265     310 ..     260     326 .. 0.51

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.3
      FAM176  73 deeeeeeeedss 84 
                  +++++++++++
  EFC39116.1 116 SNNQQQHNQQQN 127
                 111111111111 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00088
      FAM176  46 scrkdlerlkkkkkklkeesekasededeeeeeeeedsseseaeee 91 
                 + +++ +++++kk+k+k+ ++k++e+ +eee  eee ++e++ e++
  EFC39116.1 265 TSNTNNTKNTNKKNKNKNGKKKNEEEVEEEEVVEEELNEEKKKEDS 310
                 4444444455555555444444455555554444444444443332 PP

>> RP-C_C  Replication protein C C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.2      0.19   1.5e+02      49      70 ..     109     130 ..      70     152 .. 0.57
   2 ?    6.9   1.0    0.0077         6      49      93 ..     254     299 ..     245     336 .. 0.44

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.19
      RP-C_C  49 aenssanesqnerhiqnsnpds 70 
                 +e ss + +++++h q+ n++s
  EFC39116.1 109 NEYSSSSSNNQQQHNQQQNNHS 130
                 2222222222222333333321 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0077
      RP-C_C  49 aenssanes...qnerhiqnsnpdsssesepasekereekeaaaasae 93 
                 ++n+  n +    n++  +n+n++  ++ ++ ++k++ee e+++ ++e
  EFC39116.1 254 TNNNTDNITtitSNTNNTKNTNKK--NKNKNGKKKNEEEVEEEEVVEE 299
                 222222222122233333333332..1111222222222222222222 PP

>> Jak1_Phl  Jak1 pleckstrin homology-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.2    0.0011       0.9      59     101 ..     107     149 ..      88     155 .. 0.80
   2 ?   -0.2   6.6       1.2     9e+02      53      76 ..     270     293 ..     249     316 .. 0.47

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.0011
    Jak1_Phl  59 skekkkskkkkaeskkkkqeekekkeekWalFcdfqditHivi 101
                  k++ +s  ++ ++++++q++++++e++   F+  + it iv+
  EFC39116.1 107 YKNEYSSSSSNNQQQHNQQQNNHSNESPLFDFSSLKSITKIVL 149
                 455666666677778899999999999**************98 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.2
    Jak1_Phl  53 geksrkskekkkskkkkaeskkkk 76 
                 ++k++++k+k+k+ kkk e+++++
  EFC39116.1 270 NTKNTNKKNKNKNGKKKNEEEVEE 293
                 111222222222222222222222 PP

>> SPC12  Microsomal signal peptidase 12 kDa subunit (SPC12)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   2.4   9.9e-05     0.077      10      53 ..     142     187 ..     139     202 .. 0.83
   2 ?    2.6   0.4      0.19   1.4e+02      23      62 ..     210     251 ..     208     256 .. 0.65
   3 ?   -1.4   0.6       3.3   2.5e+03      25      37 ..     321     333 ..     313     344 .. 0.54

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 9.9e-05
       SPC12  10 ekllqvilvlsaviafivGyit.qd.lkltlyillagvvltllvvv 53 
                 +++++++l+++++++f++G  t q+ l+ t y++++ ++lt ++++
  EFC39116.1 142 KSITKIVLIAFCIVGFVIGISTlQNlLNGTRYMIFILCILTYILCM 187
                 6899***************976355245688899999999999885 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.19
       SPC12  23 iafivGyitqdlkltlyillagvvltl..lvvvPpWpfYnrn 62 
                 i+f++  +  ++ l  yi  + +v++   ++ +P + +Y +n
  EFC39116.1 210 ISFFYPSMRMSFALEGYIATFVIVISSfyFIAIPYYGYYDNN 251
                 566666666666666666666666654226889999999555 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 3.3
       SPC12  25 fivGyitqdlklt 37 
                 fi+G+++     +
  EFC39116.1 321 FIWGFFITFTAAM 333
                 5555555422222 PP

>> Cellulose_synt  Cellulose synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   3.2         2   1.6e+03     504     553 ..     136     185 ..     114     197 .. 0.62
   2 ?   12.8   2.3     4e-05     0.031     257     357 ..     209     315 ..     192     336 .. 0.59

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 2
  Cellulose_synt 504 ypftsifllvycilpalsllsgkfivkelsnlasiyllllflslivlavl 553
                     + f+s+  ++  +l a++++   + + +l+nl+     ++f+  i++ +l
      EFC39116.1 136 FDFSSLKSITKIVLIAFCIVGFVIGISTLQNLLNGTRYMIFILCILTYIL 185
                     55666666666666666666555555666655544444444444444444 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 4e-05
  Cellulose_synt 257 nvvffdinlr...aldG.iqGpvyvGtGcvfrrqalyGfdppkakkkkektvvsslclgkrkkkkkkkkekkkkaskk..keseaeileledide 345
                      + ff  ++r   al+G i   v v +   f     yG+   +++ ++++  ++++  +++++k+++kk+k+k+ +kk  +e+e+e +  e+ +e
      EFC39116.1 209 SISFFYPSMRmsfALEGyIATFVIVISSFYFIAIPYYGYYDNNNNTNNNTDNITTITSNTNNTKNTNKKNKNKNGKKKneEEVEEEEVVEEELNE 303
                     567888888844556763445567777788889999**988877777776665555555444444444444433333300333333333444444 PP

  Cellulose_synt 346 alegdeeekssl 357
                     + ++++++ +s+
      EFC39116.1 304 EKKKEDSHYKSV 315
                     433344333333 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   1.9     0.011       8.9      59     105 ..     114     161 ..     104     217 .. 0.65
   2 ?   -0.2   0.3       1.3     1e+03     135     141 ..     263     269 ..     204     291 .. 0.54
   3 ?    1.6   0.3      0.36   2.8e+02      65      96 ..     284     329 ..     254     343 .. 0.39

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.011
       Shisa  59 eslktgreekekqlgsalevp.kdiyvpvlivktifivfvivgvvviv 105
                 +s +++++++++q++++ e p  d+     i k ++i+f ivg v+ +
  EFC39116.1 114 SSSNNQQQHNQQQNNHSNESPlFDFSSLKSITKIVLIAFCIVGFVIGI 161
                 222222223333333333333434566666777777777777776654 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1.3
       Shisa 135 ivtetts 141
                 ++t++t+
  EFC39116.1 263 TITSNTN 269
                 1111111 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.36
       Shisa  65 reekekqlgsalevpkd..........................iyvpvlivktifivf 96 
                 ++++e++ ++      +                          +      +   fi f
  EFC39116.1 284 KKKNEEEVEE------EevveeelneekkkedshyksvlkrlfF------IWGFFITF 329
                 1111111111......1122222333333344445554444442......33333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3698  (0.206258); expected 358.6 (0.02)
Passed bias filter:                      825  (0.0460148); expected 358.6 (0.02)
Passed Vit filter:                       128  (0.00713927); expected 17.9 (0.001)
Passed Fwd filter:                        37  (0.0020637); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              23  [number of targets reported over threshold]
# CPU time: 0.89u 0.32s 00:00:01.21 Elapsed: 00:00:00.49
# Mc/sec: 2225.17
//
Query:       EFC39117.1  [L=372]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.011   15.6   2.6        1.3    9.1   0.0    3.1  2  DASH_Dad4  DASH complex subunit Dad4


Domain annotation for each model (and alignments):
>> DASH_Dad4  DASH complex subunit Dad4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   1.1    0.0022        39      23      50 ..      14      41 ..       3      48 .. 0.54
   2 ?    9.1   0.0   7.1e-05       1.3      19      57 ..      65     103 ..      63     111 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0022
   DASH_Dad4 23 LnesvvelnkeleeinkkNknvelvsql 50
                L+ + ++l  + e++n++N+n+e +  +
  EFC39117.1 14 LTTTTTTLTVNNEHVNSYNNNTEYFIGM 41
                4444455555555555555555555544 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 7.1e-05
   DASH_Dad4  19 nvekLnesvvelnkeleeinkkNknvelvsqlwenYqrn 57 
                 n+e   e v++  ++l +in++ ++ +lvs l++nY + 
  EFC39117.1  65 NIEGWLEVVKTYCRSLYDINHYASKYSLVSRLLTNYPSK 103
                 66666688899999**********************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (372 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       837  (0.0466841); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2157.09
//
Query:       EFC39118.1  [L=834]
Description: Vps52/Sac2 family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.7e-96  323.4  33.7    3.9e-96  322.8  33.7    1.2  1  Vps52        Vps52 / Sac2 family
  ------ inclusion threshold ------
      0.026   14.4   2.5       0.19   11.6   2.5    2.6  1  GIT_CC       GIT coiled-coil Rho guanine nucleotide exchange 
      0.052   13.9   2.6       0.37   11.2   2.6    2.6  1  V-SNARE      Vesicle transport v-SNARE protein N-terminus
       0.15   12.2   7.9       0.14   12.3   4.3    2.8  2  COG2         COG (conserved oligomeric Golgi) complex compone
       0.39   11.3   1.5        8.6    6.9   0.4    2.6  2  PRRSV_2b     Porcine reproductive and respiratory syndrome vi
        1.3    9.6   4.3        7.3    7.2   2.1    3.0  3  Gly_radical  Glycine radical
        1.5    8.8   8.6       0.82    9.7   1.6    3.8  4  DUF1664      Protein of unknown function (DUF1664)
        1.8    8.2   5.8       0.63    9.7   0.1    3.4  4  STAR_dimer   Homodimerisation region of STAR domain protein
        8.7    6.9   8.5         12    6.4   0.3    4.1  6  DUF4208      Domain of unknown function (DUF4208)


Domain annotation for each model (and alignments):
>> Vps52  Vps52 / Sac2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  322.8  33.7     2e-99   3.9e-96       2     489 ..     153     669 ..     152     687 .. 0.89

  Alignments for each domain:
  == domain 1  score: 322.8 bits;  conditional E-value: 2e-99
       Vps52   2 edksiedyikeseniaslhnqiaaidsvleqledlLeeFqsdlssissdikklqekSnelqlrLenrkaveaklsklvddlivppelidvIiegkvnee 100
                 e +si dy++ese +a+lh q++++d+vle++e++L++Fq  l++is +ik l+ +S  ++++ +nr++++ kls +vd +++ppel + + + +v+++
  EFC39118.1 153 ETQSIDDYLEESERLADLHIQLQQCDNVLEKMENMLQNFQGSLGNISEEIKSLRDQSFTMNIKKRNRETAQQKLSTFVDKIVIPPELTKRVCDDNVTDT 251
                 78************************************************************************************************* PP

       Vps52 101 siaekleilnkkksaekdqs..vkslkalkDvkklldkLrnkalekireyivqkiktlRkpkvnvqiiqnkLlkvkkifeFllennrklalelrqaYid 197
                 ++++ l + +kk   +  qs   + +ka+ Dv ++ldkL +k ++k+r+y++q++ +l+kpk+n+q i++ Llk+k++f F+ ++  ++  el + Y d
  EFC39118.1 252 YLEHLLTLDEKKDYIDSIQSqvKRPIKACDDVLPILDKLCTKSVSKVRSYLLQQLNELKKPKTNTQFIKQLLLKKKYYFDFVSKYSPQTGEELISIYDD 350
                 ***9998888877777666665899************************************************************************** PP

       Vps52 198 TmkkiyleyfrsYirsLtklqfeeietkddLigvedtakklffs............................ktaslkkrnkiftigkRlkilk..aql 266
                  ++++y + f+ Y  sL kl+ + ++ +  Li +e  +++l++                              +  +  +  +ft+g+Rl++l+   +l
  EFC39118.1 351 IIGRYYFNSFKTYLVSLLKLEQKVGTRQ-SLI-IE-PTQSLLNNitnitvinplsyttnmlantvglgskssESSVKDMNRSVFTLGERLNVLEnaTDL 446
                 ********************98888877.554.44.45556665677777777888888888888888876433333344579**********976678 PP

       Vps52 267 dapvlvphiaeknttkyyiEalfrslelalldnatsEYlFlkefFavsgdqaeeifeqifektlslatkyleqlisdcyDaigvllsIriinrlqleae 365
                 + p +v    e+n +k y+E +frs + +l+++atsEY+F  +fF+      e++fe +f k l+l +    q is+++D+ig+ll+Ir+   +   +e
  EFC39118.1 447 NSPLVVRVLIEQN-KKLYMEEIFRSVHILLINTATSEYIFTLDFFNN-----EQMFESLFSKSLQLLKDTWIQFISSSFDCIGILLMIRLNYLFSSLME 539
                 8888888877777.8******************************99.....99********************************************* PP

       Vps52 366 rrrvPvldsylnsvlillWPRFqlvldlnveSlrkadittlvekdtrPHeltrryaeflsslvtlsvtvkeeeverllerlqreveslilrla....kl 460
                 +r++ vldsy+++v  +l P+   +++ln++S+r+++i +l  k+   H l +r+aef+ s+  l+ + + +  ++  e+l + ++ ++++l     k+
  EFC39118.1 540 KRNMKVLDSYFDQVHSILTPKLFELFELNLNSIRESKIDQLISKEKDSHTLAKRFAEFSCSIHLLNKENPTKFKQQVEEQLLTCRDLILKQLIliseKI 638
                 *******************************************************************99999877777777777766555554222266 PP

       Vps52 461 fkkk..keqlvfLinNYdlllgvLkelsldl 489
                 f +k  k+++vfLin Ydl++   ++ + + 
  EFC39118.1 639 FTTKqfKKKQVFLINSYDLIVHQFMQSKIEV 669
                 654434899**************99988765 PP

>> GIT_CC  GIT coiled-coil Rho guanine nucleotide exchange factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   2.5   9.8e-05      0.19      14      66 .]     156     208 ..     147     208 .. 0.95

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.8e-05
      GIT_CC  14 tleeylelKkalaaseakiqqLlkvNtslsdelrlLQskvqkLqaeNaqlrdq 66 
                 ++++yle  + la    ++qq  +v ++++++l+  Q ++ ++ +e ++lrdq
  EFC39118.1 156 SIDDYLEESERLADLHIQLQQCDNVLEKMENMLQNFQGSLGNISEEIKSLRDQ 208
                 79************************************************997 PP

>> V-SNARE  Vesicle transport v-SNARE protein N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   2.6   0.00018      0.37       5      63 ..     142     202 ..     138     209 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00018
     V-SNARE   5 laeiksklarlsslag.e..erkaalreiekkldeaeelldqMelEvrnlpsserasykakl 63 
                 ++ i+  l+++ +++  +  e ++ l++++ +l++++++l++Me  ++n +     ++++ +
  EFC39118.1 142 SKHIEDDLRKIETQSIdDylEESERLADLHIQLQQCDNVLEKMENMLQNFQ-GSLGNISEEI 202
                 555666666666665423669****************************97.4445555555 PP

>> COG2  COG (conserved oligomeric Golgi) complex component, COG2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   4.3   6.9e-05      0.14      18     106 ..     122     209 ..      97     233 .. 0.81
   2 ?   -1.3   0.1       1.1   2.1e+03      89     118 ..     292     321 ..     242     328 .. 0.54

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 6.9e-05
        COG2  18 FvselrhgvpLeslrrdLeaylkllekellelvnedyadFvslSghLvglqeeleevesplaaarkkvesvreklsereeeveskleea 106
                 Fv+++  ++ +++   dL++y+k++e++l ++  + + d+++ S++L +l  +l++ +  l+++ + +++++ +l + +ee++s  ++ 
  EFC39118.1 122 FVQDELVQKAIQD-GVDLREYSKHIEDDLRKIETQSIDDYLEESERLADLHIQLQQCDNVLEKMENMLQNFQGSLGNISEEIKSLRDQS 209
                 5555333334433.349************9999999999**********************************9999999999876555 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.1
        COG2  89 reklsereeeveskleeakeleekrellkl 118
                 ++++s+ ++ + ++l+e k+ + + +++k 
  EFC39118.1 292 TKSVSKVRSYLLQQLNELKKPKTNTQFIKQ 321
                 344455555555555555555555555555 PP

>> PRRSV_2b  Porcine reproductive and respiratory syndrome virus 2b
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0      0.13   2.6e+02       6      27 ..     346     368 ..     342     371 .. 0.81
   2 ?    6.9   0.4    0.0043       8.6       5      39 ..     497     532 ..     494     540 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.13
    PRRSV_2b   6 slfdk.igqlfvdafteflvsiv 27 
                 s++d  ig+ + ++f  +lvs++
  EFC39118.1 346 SIYDDiIGRYYFNSFKTYLVSLL 368
                 6665427**************86 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0043
    PRRSV_2b   5 qslfdkigqlfvdafteflvsivdii.iflaillgf 39 
                 +slf k  ql+ d++ +f+ s  d i i+l i l +
  EFC39118.1 497 ESLFSKSLQLLKDTWIQFISSSFDCIgILLMIRLNY 532
                 79*********************9875777776665 PP

>> Gly_radical  Glycine radical
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       2.1   4.2e+03      39      63 ..     208     232 ..     170     244 .. 0.53
   2 ?    0.0   0.0      0.61   1.2e+03      59      98 ..     544     594 ..     532     599 .. 0.83
   3 ?    7.2   2.1    0.0037       7.3      19      79 ..     710     774 ..     699     787 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.1
                  CCCCHHHHHHHCC-CCCCCCHHCCC CS
  Gly_radical  39 lkavpdalgkeeeerienlatlldg 63 
                  ++++ ++ + ++e+  ++l t++d+
   EFC39118.1 208 QSFTMNIKKRNRETAQQKLSTFVDK 232
                  3333333333444444444444443 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.61
                  HHCCCCCC...........T-SECEEEEETCCCHCCCCCSCGGGCCEEEES CS
  Gly_radical  59 tlldgyfe...........ggfhlnvnvvsretLldAqehpekypqltiRV 98 
                  ++ld+yf+           + f+ln+n +++ ++ + + ++++  +l +R 
   EFC39118.1 544 KVLDSYFDqvhsiltpklfELFELNLNSIRESKIDQLISKEKDSHTLAKRF 594
                  567778855777999999999**********99999999999999999886 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.0037
                  CCCCCCTSECGCETTEETTECCCCHHHHHHHCC-CCCCCCHHCCCCCC....T-SECEEEEETCC CS
  Gly_radical  19 slnSvakldyevaldgislnlkavpdalgkeeeerienlatlldgyfe....ggfhlnvnvvsre 79 
                  sln +   +++++++g + +++++++ ++++++ + ++++++ + + +    g  h+n nv++++
   EFC39118.1 710 SLNNLNNNSNNSNNNGNNETIDLNKNFVQNRAKVDCAEMENIAKDFDKnwkqGISHINSNVLQNF 774
                  6788888899999***************99*9**999999999998755667*********9985 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.2      0.36   7.1e+02      63     108 ..     109     154 ..     100     159 .. 0.76
   2 ?    9.7   1.6   0.00041      0.82      65     116 ..     164     215 ..     138     223 .. 0.83
   3 ?   -1.1   0.1      0.95   1.9e+03      41      72 ..     278     310 ..     250     323 .. 0.63
   4 ?   -2.2   0.0         2   4.1e+03      97     121 ..     417     441 ..     402     443 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.36
     DUF1664  63 hLssridrvdkkldeqkeiskeikeevtevredlseigedvesvke 108
                 +L s++d +d +   q e+ ++  ++  ++re  ++i++d++++++
  EFC39118.1 109 ELISDLDGIDLNEFVQDELVQKAIQDGVDLREYSKHIEDDLRKIET 154
                 6778888888776666666555555555799999******999975 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00041
     DUF1664  65 ssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveglesk 116
                 s+r++ +  +l+++ ++ +++++ +++ ++ l +i+e+++s+++   +++ k
  EFC39118.1 164 SERLADLHIQLQQCDNVLEKMENMLQNFQGSLGNISEEIKSLRDQSFTMNIK 215
                 789***************************************9988877766 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.95
     DUF1664  41 davesvskqleqvs.eslaatkrhLssridrvd 72 
                 +a+++v   l+++  +s+++++  L ++++++ 
  EFC39118.1 278 KACDDVLPILDKLCtKSVSKVRSYLLQQLNELK 310
                 355555555555432456666666666666554 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 2
     DUF1664  97 seigedvesvkeaveglesklerie 121
                 ++ ++ v+ +++ v +l+++l+ +e
  EFC39118.1 417 KSSESSVKDMNRSVFTLGERLNVLE 441
                 5556778889999999999998887 PP

>> STAR_dimer  Homodimerisation region of STAR domain protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       3.8   7.6e+03      16      33 ..     171     188 ..     154     189 .. 0.62
   2 ?    9.7   0.1   0.00032      0.63      15      47 ..     273     307 ..     246     313 .. 0.87
   3 ?   -1.8   0.0       1.2   2.4e+03       1      18 [.     311     328 ..     311     332 .. 0.83
   4 ?   -3.7   0.0       4.6   9.2e+03       7      22 ..     531     546 ..     529     556 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.8
  STAR_dimer  16 KKqlaafpnvftHlerLL 33 
                 + ql++  nv+  +e +L
  EFC39118.1 171 HIQLQQCDNVLEKMENML 188
                 446777777877777666 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00032
  STAR_dimer  15 dKKqlaafpnvftHlerLLdeEIsRVRkdlfn..n 47 
                 +K+ ++a  +v+++l++L  + +s+VR+ l +  n
  EFC39118.1 273 VKRPIKACDDVLPILDKLCTKSVSKVRSYLLQqlN 307
                 6888899999******************9998544 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.2
  STAR_dimer   1 kpkptpdYLaqLLkdKKq 18 
                 kpk   ++  qLL  KK 
  EFC39118.1 311 KPKTNTQFIKQLLLKKKY 328
                 678889999****99995 PP

  == domain 4  score: -3.7 bits;  conditional E-value: 4.6
  STAR_dimer   7 dYLaqLLkdKKqlaaf 22 
                 +YL   L +K+ ++ +
  EFC39118.1 531 NYLFSSLMEKRNMKVL 546
                 7998888899998766 PP

>> DUF4208  Domain of unknown function (DUF4208)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.2      0.12   2.4e+02      11      49 ..     138     176 ..     132     190 .. 0.86
   2 ?   -1.9   0.1       2.3   4.7e+03      11      39 ..     191     218 ..     181     234 .. 0.47
   3 ?   -1.7   0.1       2.1   4.1e+03       9      42 ..     289     318 ..     282     325 .. 0.59
   4 ?    6.4   0.3    0.0059        12      69      95 ..     325     349 ..     292     350 .. 0.77
   5 ?   -4.1   0.0         9   1.8e+04      35      55 ..     418     438 ..     414     443 .. 0.79
   6 ?   -2.3   0.1       3.2   6.4e+03      55      78 ..     578     599 ..     568     628 .. 0.58

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.12
     DUF4208  11 ckellrpvkksLkrLkkltkekllskkerakilkkeLlk 49 
                 ++e+ + ++++L++++ ++ +++l+++er++ l  +L++
  EFC39118.1 138 LREYSKHIEDDLRKIETQSIDDYLEESERLADLHIQLQQ 176
                 67888999***********9999*******999988876 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 2.3
     DUF4208  11 ckellrpvkksLkrLkkltkekllskker 39 
                  +  l  + ++ k+L++++ + +  kk++
  EFC39118.1 191 FQGSLGNISEEIKSLRDQSFT-MNIKKRN 218
                 444555566666666655433.2222222 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 2.1
     DUF4208   9 eeckellrpvkksL.krLkkltkekllskkeraki 42 
                 + c +  + v+++L ++L++l+k      k + + 
  EFC39118.1 289 KLCTKSVSKVRSYLlQQLNELKKP-----KTNTQF 318
                 557778888887642666665333.....444444 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.0059
     DUF4208  69 lkkhlWefvskfwpkkvsgkkLeemYk 95 
                  kk++ +fvsk++p   +g++L ++Y+
  EFC39118.1 325 KKKYYFDFVSKYSP--QTGEELISIYD 349
                 467889********..9*********7 PP

  == domain 5  score: -4.1 bits;  conditional E-value: 9
     DUF4208  35 skkerakilkkeLlkiGdfId 55 
                 s+++ +k +++ + ++G++++
  EFC39118.1 418 SSESSVKDMNRSVFTLGERLN 438
                 678889999999999998875 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 3.2
     DUF4208  55 dellkekkeekkeklkkhlWefvs 78 
                 d+l+ ++  +++++l k++ ef +
  EFC39118.1 578 DQLISKE--KDSHTLAKRFAEFSC 599
                 4444443..455555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (834 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1879  (0.104802); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.86u 0.32s 00:00:01.18 Elapsed: 00:00:00.53
# Mc/sec: 4710.63
//
Query:       EFC39119.1  [L=968]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      2e-17   63.3   0.0      2e-15   56.7   0.0    2.7  1  E1-E2_ATPase   E1-E2 ATPase
    6.8e-07   29.3   1.2    3.3e-06   27.1   0.1    2.8  2  Cation_ATPase  Cation transport ATPase (P-type)
  ------ inclusion threshold ------
      0.022   15.1   0.0       0.16   12.2   0.0    2.2  1  Hydrolase      haloacid dehalogenase-like hydrolase
       0.16   11.7   0.8       0.62    9.8   0.4    2.2  2  LRRNT          Leucine rich repeat N-terminal domain


Domain annotation for each model (and alignments):
>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.7   0.0   4.6e-19     2e-15       6     103 ..     152     340 ..     149     358 .. 0.84

  Alignments for each domain:
  == domain 1  score: 56.7 bits;  conditional E-value: 4.6e-19
                   EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S..EEE-TTTS---S-EE-.................................... CS
  E1-E2_ATPase   6 takvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa..evdesaLTGEslpvek.................................... 64 
                   + +v+rdg++  + +++lvpGD+++l++  ++p+D+++++ ++   +des+LTG+ +  +k                                    
    EFC39119.1 152 EIRVLRDGQIYMVGSSNLVPGDVIILNNVTTIPCDCILLSTNShiLCDESSLTGDTELSHKiplfnnvnmnmnnnmnngnmnnnmnnnknvtgqtti 248
                   679****************************************9***************************************************** PP

                   ....................................................G-TTEE-TT-EEEE.-EEEEEEEE-TTTSTTTTTSTTS-- CS
  E1-E2_ATPase  65 ....................................................ekgdmvfsGtvvvs.geakavVtatgedtelgkiarlvee 103
                                                                       ++++   s+ ++ + + +ka V++tg +t  gki+r +  
    EFC39119.1 249 dqynvlvggtrivrekqtatttttnnninnnsnntndnstttihqsntttinNNNNNSNSSNNNEEgQLIKALVIKTGFHTVKGKIIRNILL 340
                   88888888888888888888888888888888888888888887777777654444444444444434468888888888888888887765 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.1   7.5e-10   3.3e-06       4      90 ..     344     442 ..     285     443 .. 0.82
   2 ?   -1.2   0.1       0.5   2.2e+03      43      77 ..     612     649 ..     587     653 .. 0.68

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 7.5e-10
  Cation_ATPase   4 NsaafsensekdevkllGnktEsALlvlaekl..............gldteelreetkkvqeipFnssrKrmsvvlklepekkvrlyvKGApeiil 85 
                    ++ + + +++ ++  l+G+  ++++l++++                  ++ + r   + ++ +pF+s+  r+sv++++    ++++y+KG+p +i 
     EFC39119.1 344 HNLHTKFDKDSNTNILIGDVIDQSMLEFTKYElkrsiqdsnlftliPPNIFSERGTLQVLKNYPFTSELQRQSVLVNNF--TNYIIYCKGSPSSIK 437
                    3333333677777779************99887788888888876666666777779********************65..*************** PP

  Cation_ATPase  86 krCth 90 
                    + C++
     EFC39119.1 438 SLCKN 442
                    ***87 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.5
  Cation_ATPase  43 reetkkvqeipFnssrKrmsvvlkle...pekkvrlyv 77 
                    +++ +++++    s++K++s++ + +   ++kk+ l +
     EFC39119.1 612 EDDSNIMEHNTVKSKNKFKSIMNSVSsshNQKKIALAM 649
                    44566666677778899988888776665666665555 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   3.6e-05      0.16     126     207 ..     622     723 ..     370     726 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 3.6e-05
                 HHHHHHHTTEEEEEEESSEHHHHHHHHHH.TT..GGGE.SEEEEHHCESSTTT.................SHHHHHHHHHHHT...STGGGEEEEESSH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xx..xxxx.xxxxxxxxxxxxxx.................xxxxxxxxxxxxx...xxxxxxxxxxxxx RF
   Hydrolase 126 avasLkaagievvlltgdnpetaeraanq.lG..ddyf.daviasdietvakp.................spegkvaaireLq...gkpeevamVGDgv 200
                 +v+s  +++++ ++ + +++++++++a    G  ++y+ +  i+ + +t+ +                  sp++k  ++  ++     +  v+m+GDg 
  EFC39119.1 622 TVKS--KNKFKSIMNSVSSSHNQKKIALAmTGeaFHYLrNQLISNIYHTHDELlpyysqllclchiytemSPNQKGNLVSDFRqylNYI--VCMIGDGS 716
                 4444..3455666666666777776666656666556655555555555333333444444444444444************8565557..******** PP

                 HHHHHHH CS
                 xxxxxxx RF
   Hydrolase 201 nDaaala 207
                 nD+ a+ 
  EFC39119.1 717 NDSIAMN 723
                 **99975 PP

>> LRRNT  Leucine rich repeat N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.4   0.00014      0.62       5      21 ..     184     204 ..     183     214 .. 0.94
   2 ?   -1.8   0.0       0.6   2.7e+03      13      20 ..     722     729 ..     721     729 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00014
                 TSEEE....CCEEEETSST-S CS
       LRRNT   5 pChCs....alvVnCsergLt 21 
                 pC C     ++++ C+e++Lt
  EFC39119.1 184 PCDCIllstNSHILCDESSLT 204
                 8*******************9 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.6
                 EEETSST- CS
       LRRNT  13 VnCsergL 20 
                 +nCs+ +L
  EFC39119.1 722 MNCSDASL 729
                 9***9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (968 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2798  (0.15606); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.05u 0.33s 00:00:01.38 Elapsed: 00:00:00.53
# Mc/sec: 5498.77
//
Query:       EFC39120.1  [L=176]
Description: acetyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.4e-14   52.7   0.0    5.5e-14   52.4   0.0    1.1  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    1.5e-07   31.4   0.1      4e-07   30.0   0.1    1.7  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    7.1e-07   29.6   0.1    1.9e-06   28.2   0.0    1.7  2  Acetyltransf_7   Acetyltransferase (GNAT) domain
  ------ inclusion threshold ------
      0.023   14.8   0.0       0.04   14.0   0.0    1.4  1  Acetyltransf_CG  GCN5-related N-acetyl-transferase
      0.031   13.8   0.3      0.042   13.3   0.3    1.4  1  Acetyltransf_15  Putative acetyl-transferase
      0.039   14.1   0.2      0.077   13.1   0.2    1.7  1  Acetyltransf_4   Acetyltransferase (GNAT) domain
      0.051   13.3   0.0      0.076   12.7   0.0    1.3  1  Acetyltransf_8   Acetyltransferase (GNAT) domain


Domain annotation for each model (and alignments):
>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.4   0.0   2.1e-17   5.5e-14      14     117 .]      31     153 ..      16     153 .. 0.73

  Alignments for each domain:
  == domain 1  score: 52.4 bits;  conditional E-value: 2.1e-17
                     HHHHHHHHHH...HHHHHHSTTC...EEEE...EEET.TEEEEEEEEEEEET..............TSTTEEEEEEEEESGGGTTSSHHHHHHHH CS
  Acetyltransf_1  14 ppnedaseee...feesfsleae...gllv...aeed.geliGfisllkipd..............ekggvayieslaVspeyrgkGlGsaLlea 84 
                     p++e a++e    +   +++ ++   g++    +++d ++liGf++++k ++              ++ ++  i+s+++  +yr+kGlG a+l+ 
      EFC39120.1  31 PEDEAATYEKlkyR---LENANSvfrGYFTsstCSDDeEKLIGFVCGTKTQNkilthdtmsvhdpsPNARTLCIHSVVIQQAYRKKGLGLAMLKS 122
                     33444444442321...22223233233334543344478************************9*999************************** PP

                     HHHHHHHTTE.SEEEEEEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  85 leerareegi.kkivlaveedndaairlYeklGF 117
                     +++++++e++ +ki l    +  + i++Ye  GF
      EFC39120.1 123 YLQYLKDENLcDKILL---LSKSHLIHFYESAGF 153
                     ********777**988...466667****99**9 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.0   0.1   1.6e-10     4e-07      52     117 ..      91     164 ..      22     173 .. 0.72

  Alignments for each domain:
  == domain 1  score: 30.0 bits;  conditional E-value: 1.6e-10
  Acetyltransf_10  52 s........hisllfVdpeyrgqGigkaLleaveeeaekdgikl.eltvnaspyavpfYeklGFkavgeeqeenG 117
                      +         i+ ++++++yr++G+g a+l+ ++++++++ +   ++ + ++++ + fYe+ GF   ge  + +G
       EFC39120.1  91 DpspnartlCIHSVVIQQAYRKKGLGLAMLKSYLQYLKDE-NLCdKILLLSKSHLIHFYESAGFILNGESNVVHG 164
                      2556666667999************************555.5556*******************98887776665 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       3.1   7.8e+03      64      74 ..      33      43 ..      13      44 .. 0.56
   2 !   28.2   0.0   7.6e-10   1.9e-06      10      75 ..      64     154 ..      57     155 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 3.1
                    HHHHHHHHTTE CS
  Acetyltransf_7 64 kaikfYeklGF 74
                      ++ Yekl +
      EFC39120.1 33 DEAATYEKLKY 43
                    23557888755 PP

  == domain 2  score: 28.2 bits;  conditional E-value: 7.6e-10
                     ETTEEEEEEEEEEES....................TCTEEEEE-GGGTTSSHHHHHHH.H......TTSE.EE...EE.EEEETHHHHHHHHHHT CS
  Acetyltransf_7  10 ddgkivGfialslld....................aeitrlaVdpeyrgkGiGraLle.a......aekg.ii...le.qlelnaekaikfYekl 72 
                     d++k +Gf++ + ++                     +i+ +++ ++yr+kG+G a+l+ +      +  + +    l  +++l     i+fYe+ 
      EFC39120.1  64 DEEKLIGFVCGTKTQnkilthdtmsvhdpspnartLCIHSVVIQQAYRKKGLGLAMLKsYlqylkdE--NlCDkilLLsKSHL-----IHFYESA 151
                     557888888888888888888888888888777655556699***************9644444321..22212223344455.....9****** PP

                     TEE CS
  Acetyltransf_7  73 GFe 75 
                     GF+
      EFC39120.1 152 GFI 154
                     **6 PP

>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   1.6e-05      0.04      24      58 ..      98     132 ..      76     139 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.6e-05
  Acetyltransf_CG  24 vldfthTeVpeelrGkGiAkkLvkaalddareegl 58 
                      +l ++ +++++++r kG++ ++ k+ l++ ++e+l
       EFC39120.1  98 TLCIHSVVIQQAYRKKGLGLAMLKSYLQYLKDENL 132
                      6778999*************************997 PP

>> Acetyltransf_15  Putative acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.3   1.7e-05     0.042      65     112 ..      91     138 ..      16     171 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.7e-05
  Acetyltransf_15  65 silieknvleiYtlyvsekyrgkGlakklLeeslkelkknYkvdnell 112
                       ++ +   l i ++++++ yr+kGl   +L+  l++lk +   d++ll
       EFC39120.1  91 DPSPNARTLCIHSVVIQQAYRKKGLGLAMLKSYLQYLKDENLCDKILL 138
                      5666777889***********************999986655555444 PP

>> Acetyltransf_4  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.2     3e-05     0.077      70     140 ..      91     159 ..      14     171 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3e-05
  Acetyltransf_4  70 kkr.akdwkaelsvylaerdnnkeglgrelidaleqvlkeqnienllaei.aspnensiqfhkalGFelvgif 140
                     ++    +  ++ sv ++ ++ +k+glg   +++l+ +l+    enl+ +i   +++  i f+++ GF l g++
      EFC39120.1  91 DPSpNARTLCIHSVVIQ-QAYRKKGLG---LAMLKSYLQYLKDENLCDKIlLLSKSHLIHFYESAGFILNGES 159
                     4444667789999***7.89*******...6666666666666889999966678889*********988875 PP

>> Acetyltransf_8  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0     3e-05     0.076      76     142 ..      95     158 ..      79     161 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3e-05
                     -TT-EEEEEEESSHHHCTTTCHHHHHHHHHHHHHCCTT--EEEE--BTT-HHHHHHHHHTT-EEEEE CS
  Acetyltransf_8  76 epgdrGiHlligeaeargkglttallralvhylfadprtrrvvvEPdvrNerairllekaGfekeke 142
                     +  ++ iH ++ ++++r+kgl+ a+l++ ++yl +++ ++++++    +   +i+++e+aGf   +e
      EFC39120.1  95 NARTLCIHSVVIQQAYRKKGLGLAMLKSYLQYLKDENLCDKILL---LSKSHLIHFYESAGFILNGE 158
                     5567889***********************************97...67788999999999976665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.44u 0.28s 00:00:00.72 Elapsed: 00:00:00.43
# Mc/sec: 1220.78
//
Query:       EFC39121.1  [L=563]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-20   73.0   0.0    2.9e-20   72.0   0.0    1.5  1  Rieske           Rieske [2Fe-2S] domain
    8.8e-12   45.0   0.0    1.9e-11   43.9   0.0    1.5  1  PaO              Pheophorbide a oxygenase
     0.0045   17.0   0.0       0.18   11.7   0.0    2.3  2  Ring_hydroxyl_A  Ring hydroxylating alpha subunit (catalytic 


Domain annotation for each model (and alignments):
>> Rieske  Rieske [2Fe-2S] domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.0   0.0   4.9e-24   2.9e-20       2      83 ..     177     263 ..     176     276 .. 0.92

  Alignments for each domain:
  == domain 1  score: 72.0 bits;  conditional E-value: 4.9e-24
                 EEEEEEGGGC-..TTCEEEEEETTEEEEEEE-TTS-EEEEESC-TTTT-BCGGSEEE...TT.EEE-TTT--EEETTSBEEE-TTHH CS
      Rieske   2 wvavakesdvp..egdpltvkvggeplvvlrdedgevyAlsdvCtHrgaplsegkid...ekgvleCpcHgwaydadGkvikgPapr 83 
                 w++va + d++  +++p  vk++geplv++r++dg+v ++ d C+Hr a+ls+g+i+   +k  leC +Hgw++++dG+++ +P+ +
  EFC39121.1 177 WYPVALSTDIKinDKKPFVVKLLGEPLVLYRTSDGQVTCTLDLCPHRSAKLSTGEITefeGKRSLECAYHGWRFEKDGQCVRIPSVS 263
                 9**********96666*************************************9995566899*********************875 PP

>> PaO  Pheophorbide a oxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.9   0.0   3.2e-15   1.9e-11       1      85 [.     425     517 ..     425     519 .. 0.85

  Alignments for each domain:
  == domain 1  score: 43.9 bits;  conditional E-value: 3.2e-15
         PaO   1 FvpPclvkiaieledeeke.....krlllvlycvPtapGksrliakfarnfaswlkkl..vPrwlkhias..nkvldqDlalLheqerklakeg 85 
                 F+pPc+v+ + +   e+++     +r++++++++Pt++++ r+i++f  ++ + l+ l  +P  ++ + +  +++ldqDl lL +  ++++k+g
  EFC39121.1 425 FIPPCFVRLDNTDYIEGGDlknagPRISQIFCMIPTGQNEHRIIFRFY-STIPVLNYLnkIPYIYSKLLQsaDTILDQDLELLFGISENVTKNG 517
                 9*********9999998889************************9977.3333444447799777766665899***************99987 PP

>> Ring_hydroxyl_A  Ring hydroxylating alpha subunit (catalytic domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.0   3.1e-05      0.18      10      48 ..     326     364 ..     313     436 .. 0.78
   2 ?    2.8   0.0     0.016        97     118     185 ..     448     515 ..     444     543 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.1e-05
                      HHHHESS-HHHHHHHHHHCCCCCTTTHHHHHHCS-TTS- CS
  Ring_hydroxyl_A  10 etldikaNWKlaaEnflEsYHvpvlHpellrallpeele 48 
                      ++ di++N+ l++En l++ H++++H  +l    +  + 
       EFC39121.1 326 KSRDIPCNYSLVLENLLDFAHLDFTHDGTLGKRSRATQV 364
                      5668************************97766666555 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.016
                      .TTTTEEEEEEESSTT-EEEEEEEEEETT...S-HHHHHHHHHHHHHHCSTTHHHHHHHHHHHHHHTTS CS
  Ring_hydroxyl_A 118 apdhvvifrviPtgpettevelealvppdat.aseelkeelaavvdrtfgvveeeDaelceevQqglrs 185
                      +p   +if +iPtg++++++  +++   +      ++   +++  + ++ ++ ++D el+ ++ +++ +
       EFC39121.1 448 GPRISQIFCMIPTGQNEHRIIFRFYSTIPVLnYLNKIPYIYSKLLQSAD-TILDQDLELLFGISENVTK 515
                      577789999***********99999877755322222222233333222.3777777777777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (563 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       566  (0.031569); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 3748.15
//
Query:       EFC39122.1  [L=490]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (490 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       586  (0.0326845); expected 358.6 (0.02)
Passed bias filter:                      426  (0.0237604); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 3273.75
//
Query:       EFC39123.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.1e-24   85.9   5.7    7.1e-16   58.4   0.2    3.0  3  BTB       BTB/POZ domain
     0.0016   18.6   1.0     0.0035   17.5   0.2    2.0  2  DUF3342   Domain of unknown function (DUF3342)
  ------ inclusion threshold ------
      0.047   14.3   2.7          3    8.5   0.0    3.2  3  MgtE_N    MgtE intracellular N domain
      0.062   13.0   2.4      0.095   12.4   0.1    2.1  2  EcsC      EcsC protein family
        1.6    8.8   6.7        2.5    8.2   0.1    3.2  4  DUF3219   Protein of unknown function (DUF3219)


Domain annotation for each model (and alignments):
>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.0   0.1   2.2e-09   8.1e-06      50     110 ..      24      86 ..      12      87 .. 0.85
   2 !   58.4   0.2     2e-19   7.1e-16       3     109 ..     106     217 ..     104     219 .. 0.89
   3 ?    4.0   0.1     0.015        55      77     108 ..     218     248 ..     216     250 .] 0.88

  Alignments for each domain:
  == domain 1  score: 26.0 bits;  conditional E-value: 2.2e-09
                 CCEEEEETTSGHHHHHHHHHHHHHSEEEC-...CGGGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  50 svseielddvepeafealLefiYtgeleit...seenleelLaaadllqiprlkkaceeflkqs 110
                  + +++ + v+++af+++Le++Yt++++ +   +++ ++e+ +aa++l ++rl  ++e++l++s
  EFC39123.1  24 MQITLD-KRVTHKAFKEVLEYLYTDKVSWDkdtEKDLIKETQEAAKYLSLDRLDVIAETYLDKS 86 
                 444443.789******************999987888999999******************987 PP

  == domain 2  score: 58.4 bits;  conditional E-value: 2e-19
                 HHHHHT.TTS-EEEEETT....TEEEEE-HHHHHHH-HHHHHHHTST.TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT CS
         BTB   3 elresg.elcDvtlvvgd....gkefkahkavLaarSpyFkalftsk.eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllq 95 
                 +lr  + +l+D+tlv+ +    + e+k+h ++L ++ +yF+ ++ ++ e e++++ +i+++d + + + a+L++iYt e+e++  ++++ +  aa+++ 
  EFC39123.1 106 NLRTGKwDLSDLTLVCSEedgkTVEVKCHAVILTSACKYFHGMLLGDvENEQKKTMRIDIEDATEKQMLAILKYIYTREFEVE-VDDVVGVWIAAHKFL 203
                 55555569*********9999999***********************6333444448*************************8.9************** PP

                 -HHHHHHHHHHHHH CS
         BTB  96 iprlkkaceeflkq 109
                 +++l+ +ce+++ +
  EFC39123.1 204 LEDLQVECESMIMK 217
                 *********99876 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.015
                 EC-CGGGHHHHHHHHHHHT-HHHHHHHHHHHH CS
         BTB  77 eitseenleelLaaadllqiprlkkaceeflk 108
                 +i+ +en+ee+ ++a++ q +r++++c e+  
  EFC39123.1 218 NIN-KENVEEIKKIAEMVQSKRIIELCDEIQH 248
                 565.89*********************99865 PP

>> DUF3342  Domain of unknown function (DUF3342)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.4   4.9e+03      46      72 ..      25      51 ..      16      65 .. 0.71
   2 !   17.5   0.2   9.7e-07    0.0035       5      94 ..     120     209 ..     117     212 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.4
     DUF3342 46 eidirvnCdlsifdWLmkyvkkkkrkl 72
                +i++  +  ++ f+ +++y+  +k + 
  EFC39123.1 25 QITLDKRVTHKAFKEVLEYLYTDKVSW 51
                566667777777887888777665544 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 9.7e-07
     DUF3342   5 vyDevknekrdfrCaqdlLetemrYfeeiikryis.eaqrleeidirvnCdlsifdWLmkyvkkkkrkltpenvvsillsssfLkmeeLvd 94 
                 v+ e   ++ + +C+  +L++  +Yf+ ++   ++ e++++  idi+   + ++   ++ky+  ++ +++ ++vv + ++++ + +e+L  
  EFC39123.1 120 VCSEEDGKTVEVKCHAVILTSACKYFHGMLLGDVEnEQKKTMRIDIEDATEKQMLA-ILKYIYTREFEVEVDDVVGVWIAAHKFLLEDLQV 209
                 788888889999***************99877665145556678998888988886.67********************998777777755 PP

>> MgtE_N  MgtE intracellular N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0   0.00082         3      28      66 ..      11      49 ..       7      76 .. 0.92
   2 ?    0.7   0.2      0.23   8.1e+02      69      99 ..     149     179 ..     148     182 .. 0.90
   3 ?    3.4   0.1     0.033   1.2e+02      69      97 ..     203     231 ..     185     246 .. 0.78

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00082
                HHHHHHHCTS-CCCCCHHHHCS-HHHHHHHHCCS-HHHH CS
      MgtE_N 28 eeaaevleeldedlqeeliealsdeelaelleeldsDda 66
                ++a+ +l+ +d ++q +l ++++++  +e+le+l++D++
  EFC39123.1 11 NTAGTTLSTIDGKMQITLDKRVTHKAFKEVLEYLYTDKV 49
                678999*******************************86 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.23
                 HHCCCHHHHHHHHHHCS-HHHHHHHHHHCTS CS
      MgtE_N  69 lleelpeekveellsaldeeereeieellsY 99 
                 ll ++++e+++ +   ++ ++ +++ ++l+Y
  EFC39123.1 149 LLGDVENEQKKTMRIDIEDATEKQMLAILKY 179
                 6889999999999999999999999999999 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.033
                 HHCCCHHHHHHHHHHCS-HHHHHHHHHHC CS
      MgtE_N  69 lleelpeekveellsaldeeereeieell 97 
                 lle+l  e  + +++++++e+ eei+++ 
  EFC39123.1 203 LLEDLQVECESMIMKNINKENVEEIKKIA 231
                 38889999999999999999999998875 PP

>> EcsC  EcsC protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   2.6e-05     0.095      42      98 ..      31      90 ..      17      94 .. 0.88
   2 ?    0.1   0.2      0.14   5.1e+02      84      84 ..     178     178 ..     100     240 .. 0.55

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.6e-05
        EcsC 42 ekitkaieealeavleggeylvekkenk...esiedlaelsLeqldelaaklakkrklaa 98
                + ++ka++e+le++ +++++ ++++e+    e+ e+++ lsL++ld  a+++ +k+k+++
  EFC39123.1 31 RVTHKAFKEVLEYLYTDKVSWDKDTEKDlikETQEAAKYLSLDRLDVIAETYLDKSKNVV 90
                56899************99999888866787888888888****************9986 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.14
        EcsC  84 d 84 
                 +
  EFC39123.1 178 K 178
                 1 PP

>> DUF3219  Protein of unknown function (DUF3219)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.1    0.0007       2.5      17      49 ..      18      50 ..       7      75 .. 0.82
   2 ?   -1.3   0.0      0.64   2.3e+03      39      54 ..      78      93 ..      52      97 .. 0.64
   3 ?    2.9   0.1     0.031   1.1e+02      20      53 ..     156     190 ..     150     194 .. 0.68
   4 ?   -1.9   0.1      0.95   3.4e+03      11      26 ..     216     231 ..     208     244 .. 0.65

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0007
                E-.SSS-EEEEEEEE-TTTHHHHTT-BS-S-EE CS
     DUF3219 17 esvkgkkkiafdlkvtseeyhdiatllyekkfd 49
                 +++gk +i++d +vt++ + ++   ly  k  
  EFC39123.1 18 STIDGKMQITLDKRVTHKAFKEVLEYLYTDKVS 50
                5789************************88754 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.64
                HTT-BS-S-EEEEETT CS
     DUF3219 39 iatllyekkfdvevPe 54
                ia    +k  +v vPe
  EFC39123.1 78 IAETYLDKSKNVVVPE 93
                4444456666777776 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.031
                 SSS-EEEEEEE.E-TTTHHHHTT-BS-S-EEEEET CS
     DUF3219  20 kgkkkiafdlk.vtseeyhdiatllyekkfdvevP 53 
                 + kk + +d++  t+++   i   +y ++f+vev 
  EFC39123.1 156 EQKKTMRIDIEdATEKQMLAILKYIYTREFEVEVD 190
                 34455566664245666777888899*******96 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 0.95
                 -SEEEEE-.SSS-EEE CS
     DUF3219  11 veaykeesvkgkkkia 26 
                 +++ ++e+v+  kkia
  EFC39123.1 216 MKNINKENVEEIKKIA 231
                 5556666666666664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1377  (0.0768029); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.41
# Mc/sec: 1827.38
//
Query:       EFC39124.1  [L=353]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-09   37.0  11.5    7.1e-09   35.4   7.9    2.7  3  PrsW-protease  PrsW family intramembrane metalloprotease


Domain annotation for each model (and alignments):
>> PrsW-protease  PrsW family intramembrane metalloprotease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.2     0.026   4.7e+02     118     139 ..      57      78 ..      49      98 .. 0.66
   2 !   35.4   7.9     4e-13   7.1e-09       8     148 ..      92     260 ..      65     273 .. 0.72
   3 ?    1.3   0.0     0.011     2e+02     155     177 ..     295     318 ..     282     334 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.026
  PrsW-protease 118 lilRillsvagHalftallGig 139
                    l++ ++++   H+l++++l ++
     EFC39124.1  57 LLIPLFFKLSFHVLWSGILSVI 78 
                    5555666677788887777643 PP

  == domain 2  score: 35.4 bits;  conditional E-value: 4e-13
  PrsW-protease   8 aaflwgalvavl.lalllntvlqall.raelgkfiaeflaaflvaglvEEllKalgvllllllrrref..................depldGivyg 83 
                     +++ g  + ++  + ++++v ++l   +++ k+  ++l +f+v+ lvEE++Kal  l l    +  f                    pl  +vy 
     EFC39124.1  92 ISIMHGLKIITVdSSSMIQSVETQLEnLSFVWKLLFGVLQSFFVSSLVEEVAKALLALKLT-SGGSFFsscfklenqteklfyhshCHPLPPMVYS 186
                    33333333333333333443333332323444556688999****************9998.4555559999999999999**99999******** PP

  PrsW-protease  84 aavglGFavlEnllYyvqal.........psaane....gqlgglqllilRillsvagHalftallGiglglaksrrr 148
                    a+++lG  ++En++ ++                 +      + g +++i Rill+ + H+l + l+G+ ++ +k r +
     EFC39124.1 187 ALAALGLSTVENIGFILVVClkiyiltsgA----SqqmvILQFGAMTVIGRILLALPLHTLSGCLVGLRIAQYKIRLE 260
                    **************9974448888865432....22344556677889*******************99999984443 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.011
  PrsW-protease 155 illlglllavllHalwNllasl.a 177
                    ++   +  + ++H+l+++++++  
     EFC39124.1 295 FFCYVIYQPLIFHGLYDFILMIdL 318
                    5666777899*********98833 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (353 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       565  (0.0315132); expected 358.6 (0.02)
Passed bias filter:                      222  (0.0123822); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 2097.53
//
Query:       EFC39125.1  [L=191]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.5e-35  119.7   0.4    8.6e-35  119.1   0.4    1.3  1  Ribosomal_L22  Ribosomal protein L22p/L17e
  ------ inclusion threshold ------
       0.12   12.0   0.0       0.14   11.8   0.0    1.3  1  FlaA           Flagellar filament outer layer protein Flaa


Domain annotation for each model (and alignments):
>> Ribosomal_L22  Ribosomal protein L22p/L17e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  119.1   0.4   9.6e-39   8.6e-35       2     103 .]      42     175 ..      41     175 .. 0.96

  Alignments for each domain:
  == domain 1  score: 119.1 bits;  conditional E-value: 9.6e-39
                    EEEEESS-HHHHHHHHHHHTTSBHHHHHHHHHT..-SST..............................THHHHHHHHHHHHHHHH..HT-GGGEE CS
  Ribosomal_L22   2 kgsnlrvsfkklrevarlIrgmkveeAlkyLkf..skkk..............................aakfvlklLknaeanaelkgldvdslv 65 
                    k + +rv+fk+++e++++I+g ++++A+kyL++   +++                              +   vlklLknae+na +kgl+v +lv
     EFC39125.1  42 KVEGVRVHFKNTCETINAIKGLSLRRAKKYLHNvlRHTEaipfkiynggpgrhahskefgvansryptkSIFAVLKLLKNAENNARVKGLNVRDLV 137
                    66789****************************8666669*****************************999************************ PP

                    EEEEEEEEEEEEEEEEEESTTEEEEEEEEEEEEEEEEE CS
  Ribosomal_L22  66 IeeiqvnkgpklkrrtyrArGrinpirkspchievvlk 103
                    I++ q+n++pk++rrt+rA+Grinp++ +p+h+e++l+
     EFC39125.1 138 ISHSQANRAPKMRRRTFRAHGRINPFMANPTHMEIILT 175
                    ************************************96 PP

>> FlaA  Flagellar filament outer layer protein Flaa
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   1.6e-05      0.14      39      89 ..       9      59 ..       1     130 [. 0.84

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 1.6e-05
        FlaA 39 velnssarlrlneanslvkeaevkeeakklagekvlGvrvkFpragnnsfa 89
                +    +a+   n++ + +++  v  e  k a++kv Gvrv+F++  +  +a
  EFC39125.1  9 IDVYIEAKCLINRTRANRQRYSVDPETSKHAKAKVEGVRVHFKNTCETINA 59
                5555567788889999999999********************987665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       518  (0.0288917); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1267.10
//
Query:       EFC39126.1  [L=675]
Description: abc transporter AbcB1 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-53  182.5  14.2    1.9e-53  181.9  14.2    1.1  1  ABC_membrane  ABC transporter transmembrane region
    3.8e-32  111.7   0.0    1.1e-31  110.2   0.0    1.9  1  ABC_tran      ABC transporter
    2.2e-07   30.5   1.6    0.00014   21.4   0.0    2.9  3  SMC_N         RecF/RecN/SMC N terminal domain
    0.00055   19.6   0.0     0.0013   18.4   0.0    1.6  1  AAA_29        P-loop containing region of AAA domain
    0.00064   19.5   0.0     0.0027   17.4   0.0    2.0  1  AAA_30        AAA domain
    0.00071   20.0   0.7     0.0028   18.1   0.7    2.0  1  AAA_16        AAA ATPase domain
     0.0016   18.2   1.1     0.0039   16.9   0.0    2.1  3  AAA_15        AAA ATPase domain
     0.0029   17.9   0.0     0.0087   16.3   0.0    1.8  1  AAA_22        AAA domain
     0.0076   16.2   0.0      0.021   14.8   0.0    1.7  1  RsgA_GTPase   RsgA GTPase
  ------ inclusion threshold ------
      0.022   15.2   0.3        1.9    8.9   0.3    2.6  1  AAA           ATPase family associated with various cellular 
      0.035   13.9   0.0       0.71    9.6   0.0    2.2  2  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
      0.036   14.1   0.2       0.24   11.4   0.0    2.4  3  AAA_5         AAA domain (dynein-related subfamily)
      0.047   12.5   0.0      0.092   11.5   0.0    1.4  1  ABC_ATPase    Predicted ATPase of the ABC class
      0.082   13.5   0.0       0.25   11.9   0.0    1.8  1  AAA_18        AAA domain
       0.12   11.9   0.1       0.38   10.2   0.0    1.9  1  AAA_7         P-loop containing dynein motor region
       0.15   11.3   0.0        1.1    8.5   0.0    2.0  2  Zeta_toxin    Zeta toxin


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.9  14.2   1.7e-56   1.9e-53       2     266 ..      83     348 ..      82     357 .. 0.95

  Alignments for each domain:
  == domain 1  score: 181.9 bits;  conditional E-value: 1.7e-56
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHS CS
  ABC_membrane   2 iliillailagvlsplfplvlgrildtlldkgdpet...ealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtn 95 
                   +++++ ++ +g++ ++f +++g ++ ++ ++ ++     ++++vy+  +++++++ ++++ll++++ln+++er+  +lr+ +f+++  q+m++fd +
    EFC39126.1  83 LIGMIGSAGSGIIPLMFQFIMGDVITVFASTTMTTAekkSQVSVYASEFAGIAAGAAVASLLSNFFLNYASERIGIALRTAYFDALTDQEMGYFDVK 179
                   789999**********************9985555567889******************************************************** PP

                   CHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHH CS
  ABC_membrane  96 svGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgirt 192
                   +vG +++ l +d+ k+++++++++++f++s+++f +g+ +++ ++wkltlv+++++p++i+  +v++ i++kl+   +k+++ + ++++E+ls +rt
    EFC39126.1 180 KVGAVTNTLYEDCTKVQEIYTTRISTFVTSIAQFAIGFSLSMSSSWKLTLVMISTTPIMIFGVFVLGGIIRKLTTMINKSNDHSAAMFTEVLSSMRT 276
                   ************************************************************************************************* PP

                   HHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHH CS
  ABC_membrane 193 VkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflsl 266
                   V+ +++ee+++ek+   l+++  ag+ kaia+g ++g++  +    +al++w+G+ lv s+el++g+   ++++
    EFC39126.1 277 VRGMAGEEKEREKYGRDLKKKFLAGVGKAIAQGSTFGVMIGVLWGTVALCFWYGGGLVVSSELNIGS--LMKVI 348
                   *******************************************************************..44443 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  110.2   0.0   9.9e-35   1.1e-31       1     137 []     421     573 ..     421     573 .. 0.87

  Alignments for each domain:
  == domain 1  score: 110.2 bits;  conditional E-value: 9.9e-35
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGG.B-HHHCCHCEEEE-SS--S-TTSBHHHH..................H CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx..................x RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlke.qeleslrkeigvlpqepqlfpeltvren..................e 80 
                 lkn sl+++ g+ va+vG++G+GKSt++ ll + ++p++G++ +d+ d+ e +++   ++ +g+++qep lf ++ ++ n                  +
  EFC39126.1 421 LKNFSLDISSGQAVALVGPSGSGKSTIVGLLERFYDPAKGKVYIDDVDVAElDPMWLHKSCLGIVTQEPVLFATT-IYGNiayaigeenatmekvveaA 518
                 79*************************************************88889999999***********99.88888*****5555554444444 PP

                 HHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  81 sdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                 + ++++ ++s l      +t +++++ sLSgGqkqr+a+arall++pk+lllDE+t+
  EFC39126.1 519 KAANCHSFISDLPE--GYNTLLGEKGVSLSGGQKQRIAIARALLQDPKILLLDEATS 573
                 44445555555554..55999**********************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       2.4   2.6e+03     172     202 ..     177     207 ..     171     217 .. 0.82
   2 !    7.0   0.1    0.0031       3.5      25      41 ..     432     448 ..     417     452 .. 0.78
   3 !   21.4   0.0   1.2e-07   0.00014     109     212 ..     500     616 ..     480     623 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2.4
                 -HHHHHHHHHHHHHHCTTSEEEEE-SSHHHC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 172 DeknvkkvaellkeksknaQfivislreeml 202
                 D k+v +v + l e+ +++Q i ++  ++++
  EFC39126.1 177 DVKKVGAVTNTLYEDCTKVQEIYTTRISTFV 207
                 8999999*******99999999888666655 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0031
                 SEEEEEESTTSSHHHHH CS
                 xxxxxxxxxxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnll 41 
                 +  a+vGp GSGKs ++
  EFC39126.1 432 QAVALVGPSGSGKSTIV 448
                 46799*********997 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 1.2e-07
                 EEEEETTEEE-HHHHHHHHHCTT-STT.................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx.................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 109 seykingkevtkkevsellesagiske.................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkekskna 190
                   y+i ++++t ++v e  + a+ ++                  +LSgG+k+ +a+a        +   + llDe  +aLD +  + v   l++  k  
  EFC39126.1 500 IAYAIGEENATMEKVVEAAKAANCHSFisdlpegyntllgekgvSLSGGQKQRIAIARA----LLQDPKILLLDEATSALDTESEALVQAALDKLMKGR 594
                 567777777777777777777666665667777777777777779*******9888754....345556899*************************** PP

                 EEEEE-SSHHHCCC-SCEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 191 Qfivislreemlekadklvgvt 212
                   i+i++r  +++++++++ + 
  EFC39126.1 595 TSICIAHRLSTVKDCNQICVLA 616
                 ***************9987655 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   1.2e-06    0.0013      16      39 ..     425     448 ..     417     459 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.2e-06
      AAA_29  16 tieidlkgatlltGpsGsGKSTll 39 
                 +++i+  +a+ l+GpsGsGKST++
  EFC39126.1 425 SLDISSGQAVALVGPSGSGKSTIV 448
                 567774459*************98 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.0   2.4e-06    0.0027      16     114 ..     430     588 ..     425     595 .. 0.78

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 2.4e-06
      AAA_30  16 sgdrvavltGpAGtGKttalkalreaweaa.g...........................grviglApt..gkaAkvLaeelgi........eastiakl 76 
                 sg + ++l+Gp G+GK+t+++ l++ ++ a g                           +  +++A t  g+ A +++ee  +        +a++ +++
  EFC39126.1 430 SG-QAVALVGPSGSGKSTIVGLLERFYDPAkGkvyiddvdvaeldpmwlhksclgivtqE-PVLFATTiyGNIAYAIGEENATmekvveaaKAANCHSF 526
                 44.5899*********************99569999999999999999999999999852.33333332277777777655433333444488888888 PP

      AAA_30  77 lkrlk........................grarlepgtllivDEagmvdtkqlaallkaaek 114
                 ++ l                         +ra l++ ++l+ DEa  +  ++ +al++aa +
  EFC39126.1 527 ISDLPegyntllgekgvslsggqkqriaiARALLQDPKILLLDEATSALDTESEALVQAALD 588
                 87777999999999999999999999999778888889999999999988888999988866 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.7   2.5e-06    0.0028      22     159 ..     429     587 ..     419     599 .. 0.46

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 2.5e-06
      AAA_16  22 grpelvllsGesGvGKsslvrellralekd....................ggiflrgkcdqlesa.......ipysa.laqalareellrqllde.... 88 
                 +++++v l+G+sG+GKs++v  l r +  +                    +             +           + +a+++    +  ++++e    
  EFC39126.1 429 SSGQAVALVGPSGSGKSTIVGLLERFYDPAkgkvyiddvdvaeldpmwlhK-------------SclgivtqE--PVlFATTIYG-NIAYAIGEEnatm 511
                 34479***************7777655555332444444444442222220.............011111110..1113444433.4444444333322 PP

      AAA_16  89 ...aesaeleawrekleeala........avpelagaeasrllellkrllallsrderplvlvlDdlq.wadeaslqllaaLl 159
                     e+a+++  + ++ +  +         + +l+g +++r++ +  r+l      ++p +l+lD++   +d++s +l +a l
  EFC39126.1 512 ekvVEAAKAANCHSFISDLPEgyntllgeKGVSLSGGQKQRIAIA--RAL-----LQDPKILLLDEATsALDTESEALVQAAL 587
                 222333333333333333333333444333333333333333322..222.....2456677777766455556666666555 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1         2   2.3e+03     133     167 ..      22      56 ..       3      96 .. 0.55
   2 !   16.9   0.0   3.5e-06    0.0039      14      65 ..     421     469 ..     420     495 .. 0.88
   3 ?   -2.8   0.3       3.5   3.9e+03     131     167 ..     632     668 ..     606     672 .. 0.54

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2
      AAA_15 133 dekisvekkkskkelpkekeeklekekeelkidke 167
                  ek ++  ++s++ ++k +++++ +++ + +i+  
  EFC39126.1  22 MEKTENTRRQSRNPFKKHNNKEAGEQISSSEIEMV 56 
                 23333333333444444444444444444444433 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 3.5e-06
      AAA_15  14 lkdveidlsee.ltvliGkNnsGKSsilealdlFlnnkekknkkvikiekedl 65 
                 lk++++d+s+     l+G+ +sGKS+i+ +l+ F +      k +++i++ d+
  EFC39126.1 421 LKNFSLDISSGqAVALVGPSGSGKSTIVGLLERFYDPA----KGKVYIDDVDV 469
                 799******9999**********************988....56666666555 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 3.5
      AAA_15 131 lsdekisvekkkskkelpkekeeklekekeelkidke 167
                 +s+ +++   +k++ +  + +ee++e ++ee+ i+++
  EFC39126.1 632 ISNGIYKGLAEKQMLFSSTTEEEEEEDDEEEILIEDK 668
                 3444444444444444444455555555555555444 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   7.8e-06    0.0087       4     105 ..     430     579 ..     427     600 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 7.8e-06
      AAA_22   4 tagilvvtGesGtGKTtllrrlleqldeeakaee................erpevvfvtlpsst.sskdllrellralglelka............... 70 
                 + + ++++G+sG+GK+t +  l + +d ++                     +++++ +  +++    ++++ +++ a+g+e+ +               
  EFC39126.1 430 SGQAVALVGPSGSGKSTIVGLLERFYDPAK---GkvyiddvdvaeldpmwLHKSCLGIVTQEPVlFATTIYGNIAYAIGEENATmekvveaakaanchs 525
                 567899*******************97544...145699999999999996666664444444445888899999999988888888888888888888 PP

      AAA_22  71 .............erlsseell.ealeqalrarav...ielliiDEaqh.lr..s 105
                                 +   l   + ++ + ara    +++l++DEa   l+  s
  EFC39126.1 526 fisdlpegyntllG-EKGVSLSgGQKQRIAIARALlqdPKILLLDEATSaLDteS 579
                 88888888877752.2333333355555555555566777999999988776532 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   1.8e-05     0.021      64     120 ..     395     452 ..     373     465 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.8e-05
                  HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  64 eleelkeelealgyevllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinall 120
                  ++e++k +++  ++++++ s  + + l++ +  +++ + ++lvG+SG GKSt++  l 
   EFC39126.1 395 KIETIKGHVRFENVDFIYPSRPNVTVLKNFSLDISSgQAVALVGPSGSGKSTIVGLLE 452
                  57777778888888888888888888888888888779***************98876 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.3    0.0017       1.9       3      98 ..     436     596 ..     434     622 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0017
                 EESSTTSSHHHHHHHHHHHH.....THEEEEEETTTCSSS........................................................... CS
         AAA   3 lyGppGtGKTllakavakel.....gvefleisgsellsk........................................................... 37 
                 l+Gp G GK++++  + +       +v++  ++++el  +                                                           
  EFC39126.1 436 LVGPSGSGKSTIVGLLERFYdpakgKVYIDDVDVAELDPMwlhksclgivtqepvlfattiygniayaigeenatmekvveaakaanchsfisdlpegy 534
                 778888888888877766643333324433333333333333344455555556666666666666655555555555555555555555555566666 PP

                 ........STTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  38 ........yvgesekkirelfkeakekakpsilfiDEidalaksrsgseseeeervvnqLlteldgvkk 98 
                         +   + +k r  +++a  + +p+il++DE+ +   ++      +e  v+++L + ++g ++
  EFC39126.1 535 ntllgekgVSLSGGQKQRIAIARALLQ-DPKILLLDEATSALDTE------SEALVQAALDKLMKGRTS 596
                 665555543333444444444444333.48888888888888777......666667777777766665 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00064      0.71       3      24 ..     435     456 ..     434     498 .. 0.74
   2 ?    1.6   0.0      0.17   1.9e+02     236     271 ..     544     576 ..     541     600 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00064
      AAA_21   3 vliGpNgsGKSnLLdaldllar 24 
                 +l+Gp gsGKS++  +l+ + +
  EFC39126.1 435 ALVGPSGSGKSTIVGLLERFYD 456
                 79***********999988765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.17
      AAA_21 236 elSdGtkrllalltallralkkgsllliDEpEngLH 271
                 +lS G+k+ +a++ all+++   ++ll+DE  + L+
  EFC39126.1 544 SLSGGQKQRIAIARALLQDP---KILLLDEATSALD 576
                 68999999999999999999...9******777776 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       3.3   3.7e+03       2      41 ..      81     120 ..      81     130 .. 0.78
   2 ?   11.4   0.0   0.00022      0.24       2      23 ..     434     455 ..     433     465 .. 0.83
   3 ?   -1.7   0.0       2.4   2.7e+03      63      78 ..     560     575 ..     502     606 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 3.3
                 EEEE--SSSSHHHHHHHGGGGBS--EEEEE--TT--HHHH CS
       AAA_5   2 vlLvGppGtgKselaerlaaalnreveyvqltrdtteedl 41 
                 ++L+G  G++ s ++  + +++   v +v  +  +t+++ 
  EFC39126.1  81 LILIGMIGSAGSGIIPLMFQFIMGDVITVFASTTMTTAEK 120
                 6899999999999999999999777777777777777665 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00022
                 EEEE--SSSSHHHHHHHGGGGB CS
       AAA_5   2 vlLvGppGtgKselaerlaaal 23 
                 v LvGp+G+gKs+++  l +++
  EFC39126.1 434 VALVGPSGSGKSTIVGLLERFY 455
                 67***************99987 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 2.4
                 --G-SEEEEESGGG-- CS
       AAA_5  63 aregeilvlDEverae 78 
                  + ++il+lDE + a 
  EFC39126.1 560 LQDPKILLLDEATSAL 575
                 3478888888887665 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   8.2e-05     0.092     299     353 ..     520     575 ..     512     605 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 8.2e-05
                 EE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS-H CS
  ABC_ATPase 299 gvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsAt 353
                  ++  +Fi++LPeg +t         SG   q  +i++al  + k+lL+DE tsA 
  EFC39126.1 520 AANCHSFISDLPEGYNTLlGEKGVSLSGGQKQRIAIARALLQDPKILLLDEATSAL 575
                 567889***********955566678****************************95 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00022      0.25       1      41 [.     434     476 ..     434     490 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00022
      AAA_18   1 IlltGtpGvGKttlakeLskrlgf....gvnlrdvakenglllev 41 
                 ++l G++G+GK+t+   L++   +    g +++d +   +l  ++
  EFC39126.1 434 VALVGPSGSGKSTIVGLLER-F-YdpakGKVYIDDVDVAELDPMW 476
                 6899**************44.3.3556666666666666555555 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   0.00034      0.38      27      52 ..     425     450 ..     407     464 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00034
       AAA_7  27 elllknkkpvllvGptGtGKtviikd 52 
                 +l +++++ v lvGp+G+GK++i+  
  EFC39126.1 425 SLDISSGQAVALVGPSGSGKSTIVGL 450
                 55678999**************9865 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0   0.00098       1.1      17      59 ..     432     474 ..     420     480 .. 0.86
   2 ?   -0.1   0.0      0.42   4.7e+02      74     114 ..     573     613 ..     568     632 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00098
  Zeta_toxin  17 klillgGqpGAGKselaellkdelerqgnvvrldpDdlRelhP 59 
                  ++ l+G +G+GKs++  ll++  +++++ v +d  d+ el P
  EFC39126.1 432 QAVALVGPSGSGKSTIVGLLERFYDPAKGKVYIDDVDVAELDP 474
                 6899******************999999999999877766665 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.42
  Zeta_toxin  74 eltqkdaselvekllqeaiengyniivegtlrspdvvkkla 114
                 +  + ++  lv+ +l+++++ + +i +   l++  +++++ 
  EFC39126.1 573 SALDTESEALVQAALDKLMKGRTSICIAHRLSTVKDCNQIC 613
                 5567788999***************9988888888777654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (675 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1294  (0.0721736); expected 358.6 (0.02)
Passed bias filter:                      764  (0.0426125); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.74u 0.32s 00:00:01.06 Elapsed: 00:00:00.45
# Mc/sec: 4511.51
//
Query:       EFC39127.1  [L=662]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      1e-56  192.3   9.2    9.2e-56  189.2   2.1    3.1  2  Mlh1_C          DNA mismatch repair protein Mlh1 C-terminus
      8e-13   48.4   0.0      3e-12   46.5   0.0    2.0  1  HATPase_c_3     Histidine kinase-, DNA gyrase B-, and HSP90-l
    2.6e-06   27.1   2.6     0.0011   18.7   0.4    2.6  2  DNA_mis_repair  DNA mismatch repair protein, C-terminal domai
    2.1e-05   25.0   0.0    5.7e-05   23.6   0.0    1.7  1  HATPase_c       Histidine kinase-, DNA gyrase B-, and HSP90-l


Domain annotation for each model (and alignments):
>> Mlh1_C  DNA mismatch repair protein Mlh1 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.8      0.26   1.2e+03     166     166 ..     260     260 ..     177     426 .. 0.58
   2 !  189.2   2.1   2.1e-59   9.2e-56       2     270 .]     431     662 .]     430     662 .] 0.93

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.26
                 T CS
      Mlh1_C 166 e 166
                 +
  EFC39127.1 260 N 260
                 2 PP

  == domain 2  score: 189.2 bits;  conditional E-value: 2.1e-59
                 -HHHHHHHHHHHHHB-HHHHHHHHT-EEEEEEETTEEEEEETTEEEEEEHHHHHHHHHHHHHHHHTT--EEEE-G-.-BHHHHHTTS-SHH........ CS
      Mlh1_C   2 ltsvkelraeveesahkeLteilanltfVGlvderlaliQhgtkLylvdygalskelfyqllLtdFgnfgeikLeeplslkeLlelaleeeeeeeeees 100
                 l+s k+lr++++++ h eL+++l+++++VG ++ +++l+Q++ +                 +L +Fg+f++i+L+++l++k++l+   +++        
  EFC39127.1 431 LESLKSLRNSINAKNHAELEKLLRSSSYVGYINAKYSLVQFNDR-----------------VLAKFGRFKKINLKNSLDVKTILQGVSDND-------- 504
                 89**************************************9876.................699********************6554444........ PP

                 .........HHHHHHHHHHHTHHHHHHHH--EETT-EEEEEEEE-STT----STTHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHS----.---... CS
      Mlh1_C 101 eeedkskeelaekivelLiekaemLeeyFsieidedgellslPlllkgytpslekLPlfllrLateVdWeeekeCfetilrelAlfyapeqlpekeese 199
                         e+++++ ++L+ek+e+L+eyFs+ i+ed +l+slP +l++y+p+++++P fl+ La +V+W++e  Cf+ + + +++fy   +  e     
  EFC39127.1 505 --------EVIREALSVLNEKKEILQEYFSVCITEDLKLVSLPHVLENYIPPMHRVPDFLYALAFKVNWDSEIGCFSDVSTVISSFYNLCEDFEL---- 591
                 ........699*****************************************************************************5555443.... PP

                 .-T.T-...TTS-HHHHHHHHHHHHHHHHHHHHTHHHHHHHH---BGGGGG..GEEEEEEHHHHHHHS--- CS
      Mlh1_C 200 ekaseeekeeeeeeeeeeeaeerreelkwvlehvlfpaikarllppksllkdgtvvevasledLYkVFERC 270
                 e++se++++++++e++ +++  ++++++w+ eh++fp+ik  + pp+s+++dg++veva+l++L+kVFERC
  EFC39127.1 592 EDESENDSQKSSQEANANSTLYSKQRMRWITEHLVFPSIKLLFKPPESVVNDGSIVEVANLPELFKVFERC 662
                 444466677888888999999999*********************************************** PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.5   0.0   6.7e-16     3e-12       4     106 ..      42     144 ..      38     151 .. 0.90

  Alignments for each domain:
  == domain 1  score: 46.5 bits;  conditional E-value: 6.7e-16
  HATPase_c_3   4 ekAlaelvdNsldAdaenvkievnknrgktgeivieDdGkGmseeelknalrlatsskeak.rkstslGkkGi.GlklAslslgkkltvitkkegess 99 
                    A+ el++NsldA a +++ie+ +     + ++i+D+G G+  ++l+ + + +t+sk ++ ++ +s+  +G+ G  l+s+s ++++t+++k+e++s+
   EFC39127.1  42 SNAIKELLENSLDAGADSITIEFGDAG--LKYFQITDNGCGIGAKDLEIVCERHTTSKLSSfEDLRSIATFGFrGEALSSVSTCAHVTITSKTEQQST 137
                  679*********************974..699*****************9999999998664578889999999999********************9 PP

  HATPase_c_3 100 tltldvd 106
                  +l+ +++
   EFC39127.1 138 ALFATYR 144
                  9887765 PP

>> DNA_mis_repair  DNA mismatch repair protein, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.1   0.00036       1.6       1      48 [.     228     276 ..     228     276 .. 0.80
   2 !   18.7   0.4   2.3e-07    0.0011      89     118 ..     277     306 ..     276     307 .. 0.94

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00036
                     HHHHHHHHHHCCEEEEEEEETTEEEEEEEE-CCG-BTT.GGEEEEEETT CS
  DNA_mis_repair   1 iaavlgkevaenlleiekeeeqlkieGfiskpelsrsk.rdkqflfvNg 48 
                     i+a++g ++ ++++e + ++e+++++G +   +++ s+ ++  +lf+N+
      EFC39127.1 228 IKALFGPKIEKEIIEADINNEKIELTGKMYFTNVNYSSkEKAFTLFINN 276
                     5789*************9999*999997776666655514667789996 PP

  == domain 2  score: 18.7 bits;  conditional E-value: 2.3e-07
                     -TSSTT----EETTHHCHHHHHHHHHHHHH CS
  DNA_mis_repair  89 vNvhPtKreVrfqdeeevieaieealkeal 118
                     vN+hPtK+eV   de+ +ie +++ l++ l
      EFC39127.1 277 VNMHPTKKEVAVLDEDRIIEEVKDVLRKKL 306
                     9************************99876 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.6   0.0   1.3e-08   5.7e-05       9     101 ..      44     135 ..      39     163 .. 0.70

  Alignments for each domain:
  == domain 1  score: 23.6 bits;  conditional E-value: 1.3e-08
                 HHHHHHHHHHHHHSTTTEEEEEEEEEETEEEEEEEESSSSSTTHHHTGTCSTTCH......HCSTCHTSTSSSH.HHHHHHHHHHHTTTEEEEEEETTT CS
   HATPase_c   9 iisnlvdNavkfatkageieveikaseddlvisveDnGiGipkedlkklfekfsq......ddstkrggggtGl.GlsivkklvelmgGeiwvesepgr 100
                 +i++l++N++++   a++i++e   + + + ++++DnG+Gi  +dl+ + e++++      +d +++    +G+ G +++   ++    +++++s+ ++
  EFC39127.1  44 AIKELLENSLDA--GADSITIEFG-DAGLKYFQITDNGCGIGAKDLEIVCERHTTsklssfEDLRSIA--TFGFrGEALSSV-ST-C-AHVTITSKTEQ 134
                 699********6..7999999999.558999****************666655554555354444444..444434444432.11.1.24555555544 PP

                 E CS
   HATPase_c 101 G 101
                  
  EFC39127.1 135 Q 135
                 4 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (662 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1628  (0.0908026); expected 358.6 (0.02)
Passed bias filter:                      626  (0.0349155); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.78u 0.32s 00:00:01.10 Elapsed: 00:00:00.50
# Mc/sec: 3979.13
//
Query:       EFC39128.1  [L=832]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0028   17.9   0.0      0.019   15.3   0.0    2.3  1  AAA_22    AAA domain
  ------ inclusion threshold ------
      0.012   16.0   0.0      0.054   13.9   0.0    2.2  2  AAA_16    AAA ATPase domain
      0.023   14.9   0.0      0.069   13.4   0.0    1.7  1  HHH_3     Helix-hairpin-helix motif
      0.075   13.4   0.0        0.2   12.0   0.0    1.8  1  AAA_19    AAA domain
       0.23   11.3   1.9        0.4   10.6   0.7    2.1  2  KilA-N    KilA-N domain


Domain annotation for each model (and alignments):
>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.0   5.2e-06     0.019       8     117 ..     212     351 ..     206     376 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 5.2e-06
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaeeerpevv..fvtlpsstsskdllrellralglelka..............................erls 74 
                  ++ + +G+GK++ll+++   l    k +e +++++  fvt  +++s +++ + +  +  l l                                 +  
  EFC39128.1 212 SFIAAAPGVGKSRLLKEMGVLLA---KTKELSVDYFplFVTFGNGCSYDQIVESFRPIESLLLRMiysivvcfidmefdafrksfsafvknrtlsMTTV 307
                 578899*************9994...4455455555567777777777777555544444433335567777777777777777777777733334444 PP

      AAA_22  75 seellealeqalraravielliiDEaqhlr...seealeeLrslln 117
                 + +++++l +++++ +    + iDEa+ ++   +e++l+ Lr+++ 
  EFC39128.1 308 LTAFRQRLFENSDKIGF--YIAIDEAHSVNtgtNEKQLNPLRQIMS 351
                 45555555556666666..788*******97644*******99876 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   1.5e-05     0.054       1     146 [.     176     333 ..     176     355 .. 0.58
   2 ?   -3.9   0.0       4.2   1.5e+04     139     157 ..     681     702 ..     669     708 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.5e-05
      AAA_16   1 rlvGReeeleqLlsalervrsgrp..........elvllsGesGvGKsslvrellralekd..............ggiflrgkcdql.esaipysa.la 73 
                 ++vGR+e ++++ +++++  s             +l ++  ++GvGKs+l++e    l k+              g     + +dq  es +p    l+
  EFC39128.1 176 EFVGRDEPVNAIMNVYQKQDSKIKdkeiidksdvRLSFIAAAPGVGKSRLLKEMGVLLAKTkelsvdyfplfvtfG---NGCSYDQIvESFRPIESlLL 271
                 59**************944444334467999999*****************9988655555555544332211111...11111111222333333244 PP

      AAA_16  74 qalareellrqlldeaesaeleawrekleealaavpelagaeasrllellkrll.allsrderp.lvlvlDdlqw 146
                 +++   +++    d++ +a +  ++++ + ++            ++  +l+++  +l ++ ++  +++ +D+++ 
  EFC39128.1 272 RMI-Y-SIVVCFIDMEFDAFRKSFSAFVKNRT-----------LSMTTVLTAFRqRLFENSDKIgFYIAIDEAHS 333
                 444.2.33333333333333333333333333...........46666666666666666555357777777765 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 4.2
      AAA_16 139 lvlDdlq..wadeaslql.laa 157
                 +++ ++q  wad++s +l la+
  EFC39128.1 681 ILVFHIQckWADSESGNLsLAE 702
                 4444556669999999997765 PP

>> HHH_3  Helix-hairpin-helix motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   1.9e-05     0.069       8      51 ..     776     818 ..     770     820 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.9e-05
       HHH_3   8 iNtAsaeeLqklpGlgpklAknIvayReknGpfksreeLlkvkg 51 
                 iN +   eLq ++ +g+k A  I++ R +  +f + ++L+k+ g
  EFC39128.1 776 INECNCNELQSFKSVGDKEAATIIEKRGES-GFVDDDDLQKKTG 818
                 9**************************555.7999999999876 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   5.7e-05       0.2       3      50 ..     202     250 ..     200     347 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 5.7e-05
      AAA_19   3 eavealkekvllvtaGpGtGKTrvlkhivallvelggvkpeei.llvaf 50 
                 e+++++  ++ ++ a pG GK+r+lk++  ll ++++++++ + l v+f
  EFC39128.1 202 EIIDKSDVRLSFIAAAPGVGKSRLLKEMGVLLAKTKELSVDYFpLFVTF 250
                 67778889999*****************999999999887544245555 PP

>> KilA-N  KilA-N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.7   0.00011       0.4      14      98 ..       6     113 ..       1     119 [. 0.64
   2 ?   -3.5   0.0       2.6   9.5e+03      13      28 ..     297     313 ..     295     341 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00011
      KilA-N  14 kdgyinatkllkaa.aedtkr...iddWlrnkstkelleeleedynise.kk....................ksektisenrkakpgr.lqGtYvhpdl 86 
                 k+   +atkl+++  ++++k    i++W ++    ++l++l+e+ +  +                       +s+kt +e ++a  ++ + G  +h+d+
  EFC39128.1   6 KKRLACATKLFSIPnSKKRKTieeIRKWNQS----DVLNALKEELGLCDdDLnqqlrgmhlynaicayqtctESNKTPQEAKQAVINSlMDGKDIHKDI 100
                 4566789999999954444443334444444....55555555555553223667899999988877766543345555555554444588******** PP

      KilA-N  87 alavasW.ispef 98 
                 a a+a+W i++ +
  EFC39128.1 101 AEAIANWlITDLI 113
                 *******888765 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.6
      KilA-N  13 vkdgyinatkllkaa.a 28 
                 vk+   ++t +l+a+ +
  EFC39128.1 297 VKNRTLSMTTVLTAFrQ 313
                 67888899999999832 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (832 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       854  (0.0476323); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.83u 0.34s 00:00:01.17 Elapsed: 00:00:00.54
# Mc/sec: 4668.00
//
Query:       EFC39129.1  [L=177]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.4e-29  100.1  31.3    7.1e-19   67.9  11.0    2.2  2  ATP-synt_C    ATP synthase subunit C


Domain annotation for each model (and alignments):
>> ATP-synt_C  ATP synthase subunit C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2  12.3   7.4e-14   1.3e-09       1      60 []      24      83 ..      24      83 .. 0.97
   2 !   67.9  11.0   3.9e-23   7.1e-19       1      59 [.     102     160 ..     102     161 .. 0.98

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 7.4e-14
                HHHHHHH.GGGHHHHHHHHHHHHHHHHHHHHSGHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ATP-synt_C  1 lgaglavGlsalgsGigiGkagsagiravarnpklftksliilafaeaialygLivalil 60
                +g++ a++++ lgs++g +kag + +     + +l +k ++++++a+++++ygLiv++i+
  EFC39129.1 24 MGCASALIFANLGSAYGSAKAGVGVAHLGIMDHRLVMKGIVPVIMAGILGIYGLIVSIII 83
                588999****************************************************98 PP

  == domain 2  score: 67.9 bits;  conditional E-value: 3.9e-23
                 HHHHHHH.GGGHHHHHHHHHHHHHHHHHHHHSGHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ATP-synt_C   1 lgaglavGlsalgsGigiGkagsagiravarnpklftksliilafaeaialygLivali 59 
                 l+ gl++Gls l++G+ iG++g+ag+ra +++ k+f+++++il+f ea++lygLival+
  EFC39129.1 102 LASGLSCGLSSLAAGLSIGVVGDAGVRAYGKQQKVFVGLILILIFGEALGLYGLIVALV 160
                 799******************************************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (177 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       536  (0.0298957); expected 358.6 (0.02)
Passed bias filter:                      234  (0.0130515); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.50
# Mc/sec: 1069.87
//
Query:       EFC39130.1  [L=103]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.8e-23   82.0   0.1    5.2e-23   81.9   0.1    1.0  1  EMP24_GP25L  emp24/gp25L/p24 family/GOLD


Domain annotation for each model (and alignments):
>> EMP24_GP25L  emp24/gp25L/p24 family/GOLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.9   0.1   2.9e-27   5.2e-23      84     182 .]       2      98 ..       1      98 [. 0.94

  Alignments for each domain:
  == domain 1  score: 81.9 bits;  conditional E-value: 2.9e-27
  EMP24_GP25L  84 stksskkvsfdievgseasdykdsakkekletleselkkleekldsikreqkylrereerlrdtnestnsrvvwwsilqllvlvlvavlqvyyLkrfF 181
                  s+ +sk+vsf+i+vg+    + +  k ++ +++ +++ +l e l++i++eqk++r+ree++rd++e tn++v++w +++++ +v++av qv++L++fF
   EFC39130.1   2 SKLTSKTVSFEIHVGDL--LDPNLSKLDEKDPIVKSVLRLTEGLSEIQTEQKFYRTREESHRDLAEITNEKVMFWGVAEMIGIVVMAVGQVFVLRNFF 97 
                  56677*********964..57899999999******************************************************************** PP

  EMP24_GP25L 182 k 182
                  k
   EFC39130.1  98 K 98 
                  7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       811  (0.045234); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.48
# Mc/sec: 646.82
//
Query:       EFC39131.1  [L=1187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.1e-44  149.8   9.8    8.1e-44  149.8   9.8    3.3  3  MIF4G     MIF4G domain
  ------ inclusion threshold ------
      0.057   13.4  31.8      0.012   15.6  17.7    2.3  2  TFIIA     Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> MIF4G  MIF4G domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  149.8   9.8     9e-48   8.1e-44       4     212 .]     481     701 ..     478     701 .. 0.97
   2 ?   -1.2   0.2      0.14   1.3e+03     154     181 ..     822     854 ..     801     930 .. 0.66
   3 !    5.5   0.2    0.0013        12     114     196 ..     945    1019 ..     937    1079 .. 0.83

  Alignments for each domain:
  == domain 1  score: 149.8 bits;  conditional E-value: 9e-48
                 HHHHHHCHTTTTHHHHHHHHHHHHHCS..CHHHHHHHHHHHHHHHHHCGGGHHHHHHHHHHHHHHSH........HHHHHHHHHHHHHHHHHHC..... CS
       MIF4G   4 vkgilnklskenfevlikqllklamdd..dknelkevielifekaveepsfsplyarlcgklnsrfq........qnFrikllnklqeefekry..... 87 
                 vk iln+l++en+e l  ++l+++++   d++ l+ +i++if  a+   +fs lya+lc+ l+++++        + F++ llnk+q+efe+ +     
  EFC39131.1 481 VKFILNRLTPENYERLKIEFLNACIKKpgDEAVLNGIIDQIFIFAINLQNFSALYAKLCADLSNELKerigeentKQFKRLLLNKCQKEFENEKkeele 579
                 788*****************************************************************************************99***** PP

                 ......-S-HHHHHHHHHHHHHHHHHHHHHHHHHHTTSSEHHHHHHHHHHHHHGGCCCCSCCHSCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH CS
       MIF4G  88 ......eleneleenedgnrrrrlglvrflgelfklkmltskilldclkellssltketaddppqdleeieilltllttigktlennekakkeldqffk 180
                          +e ee+e   r+++ g+++f+gel+ + ml++ki+++++k+ll + t        ++ ++ie+l++llttig +l+ +ek+kk ++ +f 
  EFC39131.1 580 kaaqvgLSPEEVEEKEFLLRKKKVGNMIFIGELYLQDMLSEKIMHEVIKRLLVNPTP------YPSSDDIELLCRLLTTIGSKLD-HEKSKKYVNYYFG 671
                 ***9998888999*****************************************999......78********************.************* PP

                 HHHHHHHCCHCSSSSHHHHHHHHHHHHHHHTT CS
       MIF4G 181 riqkiledatrqelssrirfmlkdlielkknk 212
                 ++++ ++d+  ++l+sr+rfml d+i+ + n+
  EFC39131.1 672 KMETLAQDK--DNLASRLRFMLRDVIDMRINN 701
                 ********8..*****************9886 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.14
                 HHHHHHHHHHHHC.....CCHHHHHHHHHHHHH CS
       MIF4G 154 lltllttigktle.....nnekakkeldqffkr 181
                 + + ++ + ++ e     ++ek+k+ +++ff++
  EFC39131.1 822 VIEEVEVVPEETEeqikeTTEKTKRIINNFFEE 854
                 445555555555555555555555555555543 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0013
                  HHHTTSSEHHHHHHHHHHHHHGGCCCCSCCHSCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHCSSSSH CS
       MIF4G  114 lfklkmltskilldclkellssltketaddppqdleeieilltllttigktlennekakkeldqffkriqkiledatrqelss 196 
                  lf   +++    ++cl+++l  +   ++d p+q+++ + il +++ ++  + e    + + l+++++ +++ le+   +++ s
  EFC39131.1  945 LFGRLLFEKVLPFNCLYDILVTVVL-DEDAPLQEEHAFDILKNVFASVKSECE----LNDDLKKILANYEDELEN---HLVLS 1019
                  55555666677899******99998.557999999999999999999999999....778888888888888887...44444 PP

>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.6  17.7   1.4e-06     0.012      98     333 ..      74     351 ..       4     364 .. 0.55
   2 ?    3.4   6.1    0.0069        62     190     298 ..     719     843 ..     662     893 .. 0.41

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 1.4e-06
       TFIIA  98 gksvqsltanssaataatfslpakleppvqipagvtlqtasgqlykvnv........qasgaqqiaaqplqqvvqqsqgsaaqssvaalqaq.sqqaqa 187
                 g+s qs+++n++++t++t+++pa+ eppv +  +++    +++l++v           + +a  +++++  q     + s + +  + ++++ +q++q 
  EFC39131.1  74 GSSNQSYQSNNNTNTNTTYTPPANYEPPVVVQQSYN----NPSLNSVRNadignhiqRTASAPPAISEHTPQH----NHSKIPEHKTYVKNTyPQHQQP 164
                 44566777567779*************555555444....444444444454422333333333333333333....4444444444455555778888 PP

       TFIIA 188 laepqqqlekq...............................qqqqqqqqqqqqqqqvqqqqqe......................esqqaqqasqe.. 231
                 +  pq+q +++                                                    +                      e +++++a  +  
  EFC39131.1 165 IFYPQMQPAMGypippvgyppygypssepksttsseivkparS--------------------SkiviadpksgkevnilddkssnETASTTEA--Ttt 241
                 8888888444478888888887666555444433333333321....................1344444444455555554333222222222..122 PP

       TFIIA 232 qvagsqvessqtdgaedaleeespv...legelsaeeeagaqkeelsreeidrire..........ealkakelekeskkkkraeessla.......dl 310
                 +++++ v+ s+t +  + +++ ++    +e  ++++eea+  +e+ ++ e     +            l+ +e+ ++sk+         +        +
  EFC39131.1 242 STTTTPVTISTTTETTETATTTATTepiVEEAPKQTEEATPVEEKQTELETP---QtpiseytetpTTLEGEETFDNSKS---------SdidedkvIK 328
                 2222333333333333222222222222555555555444433333332222...1233344433322222222222222.........1223333367 PP

       TFIIA 311 seilqlDGagddsdeeeeeeesd 333
                 ++   +DG +d+s+eeeee e +
  EFC39131.1 329 EDPSEIDGMEDSSEEEEEEGETE 351
                 88999999999999966554333 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.0069
       TFIIA 190 epqqqlekq.qqq.qqqqqqqqqqqqvqqqqqeesqqaqqa.sqe...............qvagsqvessqtdgae.........daleeespvlegel 261
                 +     ++q  q    ++++++ +++v++++  ++++++++ + +               +             +          + +++++++  + l
  EFC39131.1 719 RDDAV-KQQmDQIkKIEKHHHNRKTTVKTKTVYNNNNNNNNnK-QsglqaeryrkmdakkT-----------LAPGggnlitkapSPTQSKKDLNSFSL 804
                 11111.1111111122222222222333333222222222211.11331122222222221...........222222222211111111111122222 PP

       TFIIA 262 saeeeagaqkeelsreeidri.re.....ealkakelekeskk 298
                 ++ ee+++    +s+ee +++ +e     e  ++++++++++k
  EFC39131.1 805 LEDEEEKE---PVSEEEEEEViEEvevvpE-ETEEQIKETTEK 843
                 22222222...1222222222222222321.112222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2601  (0.145072); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.15u 0.36s 00:00:01.50 Elapsed: 00:00:00.55
# Mc/sec: 6541.70
//
Query:       EFC39132.1  [L=186]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-15   58.0   0.0    1.8e-15   57.2   0.0    1.4  1  OsmC      OsmC-like protein
  ------ inclusion threshold ------
      0.017   15.1   0.3       0.49   10.4   0.1    2.1  2  META      META domain


Domain annotation for each model (and alignments):
>> OsmC  OsmC-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.2   0.0     2e-19   1.8e-15       1      97 [.      75     178 ..      75     181 .. 0.89

  Alignments for each domain:
  == domain 1  score: 57.2 bits;  conditional E-value: 2e-19
                 TTXSSB-HHHHHHHHHHHHHHHHHHHHTCCCT---SCE.EEEEEEEEECCECT.......CEEEEEEEEEEE-SS-H..HHHHHHHHHHHHHSHHHHHH CS
        OsmC   1 gdgsgpsPeelllaalasCfaitlravakkkgikledl.eveveaerdpegak.......giteirlkvevkipgadseeklkkllekaekrCpvsntl 91 
                 g+++gp+P el la+l++C +it+r  a+ ++++++++  +++++  d +g +        ++++++ +ev++ ++   e+++ l e++e+ Cpv +++
  EFC39132.1  75 GTNQGPTPLELSLASLSGCEIITARYAARGMKMQIKSIsCTKMSGVLDVRGLRgvagvpaHFKSVDMVFEVETNESN--ERIDTLKERVERSCPVFQMF 171
                 7899**********************************75667788888887788899999**********988766..******************** PP

                 .CT-SSS CS
        OsmC  92 .kngvkv 97 
                  +++v++
  EFC39132.1 172 kAANVTM 178
                 6666665 PP

>> META  META domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.012   1.1e+02      58     100 ..      12      57 ..       2      65 .. 0.81
   2 ?   10.4   0.1   5.5e-05      0.49      35      66 ..      87     118 ..      63     123 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.012
                 SSEEE-----..SCHHHHCHHHHHHCCCH-CEEEE-SS.EEEEE-T CS
        META  58 galasTrmaC..spalmelEqallkaLqavtsyriegd.rLtLtda 100
                 +++ s ++ C  +++ +++E++++k L++ + ++i+++ +L++++a
  EFC39132.1  12 NNFSSVMNRCleEKKPAAAEEDVSKYLKTFNITSISEEgSLVVSTA 57 
                 566677788887888999***********99999998888888866 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 5.5e-05
                 EEEE-SSSEEEEEEEECTTEEEESSEEE---- CS
        META  35 vsgsagCNrfsGsytleggrltlgalasTrma 66 
                 ++  +gC  ++++y+ +g +++++++  T+m 
  EFC39132.1  87 LASLSGCEIITARYAARGMKMQIKSISCTKMS 118
                 55668*************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       487  (0.0271627); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.33s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1131.27
//
Query:       EFC39133.1  [L=281]
Description: hypothetical protein NAEGRDRAFT_81398 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.069   12.9   0.0       0.11   12.3   0.0    1.2  1  MukF_M    MukF middle domain


Domain annotation for each model (and alignments):
>> MukF_M  MukF middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   5.9e-06      0.11      58     128 ..     197     267 ..     181     276 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.9e-06
                 HHHHHHHHHHHHHHHHHHHGGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSSS-HH CS
      MukF_M  58 mdeqqqqvkeeiaellnkdWreaisscekllsetsstlrelqdtleaaGdklqaellriqeavlgreelel 128
                 +d   +++++  ++lln  W +a  s ekll + ss  r  +   +  G   q e ++i ++++++e  e 
  EFC39133.1 197 VDSFEKNIRQFFSTLLNDWWCSANDSSEKLLVNHSSIARKKKAGRDRYGPTYQEENIEILSVTYESEGKEP 267
                 57778899999*******************************************99999999988876655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (281 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1816.91
//
Query:       EFC39134.1  [L=230]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (230 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       405  (0.0225891); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1427.79
//
Query:       EFC39135.1  [L=430]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.1e-11   42.0   0.1    0.00014   20.8   0.1    2.9  2  DUF1479   Protein of unknown function (DUF1479)
    0.00027   21.3   0.0        1.3    9.3   0.0    3.1  3  PhyH      Phytanoyl-CoA dioxygenase (PhyH)
  ------ inclusion threshold ------
      0.026   14.5   0.3       0.17   11.8   0.1    2.5  2  UBA_6     UBA-like domain
      0.036   14.3   0.5      0.083   13.1   0.5    1.5  1  DUF2097   Uncharacterized protein conserved in archaea (DUF20
      0.098   11.4   0.0       0.13   11.0   0.0    1.2  1  MCRA      MCRA family


Domain annotation for each model (and alignments):
>> DUF1479  Protein of unknown function (DUF1479)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.1   3.9e-08   0.00014     234     388 ..      54     240 ..      32     253 .. 0.78
   2 !   16.7   0.0   6.9e-07    0.0025      65     170 ..     298     428 ..     279     430 .] 0.83

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 3.9e-08
                 --SEEEEEESS-....B-TTCT-EEE-S-TT.HH.HHHHHHCCSTTS-..............................................TT-ST CS
     DUF1479 234 fRtfQGwlalsd....vkpgeGtlrvlPlvklat.aYllLRpffeekkeeeelaee.................................lkeeqdsklp 294
                 fR fQ++++l+d     +++eG l+v+P   ++   Y+    +  +    +e++ +                                 +    +++l 
  EFC39135.1  54 FRPFQSMVCLTDgcvnRHKKEGGLEVIPGFASVCeKYFPAVDLKLRSA--SEMRAKspwvssyhlrfnkeedkplyelvrkvqripqnwNPPPANNTLD 150
                 99********96433357889*******88755414653333322222..222222457777899************9999998877632223333333 PP

                 T--TTS-EE--TTT-HH..HHTT-EE---B-TT-EEEEETT--EEE-SBCSSSS-EEEEE--B-EESHHHHHHHHHHHHHHHHT---TTS-S-- CS
     DUF1479 295 gavpgsaqelteelhphLelketlvsiPdleaGDyvvWhcdlihavdkehegkkdssvlYipavPltqknaeylarqrkaflrgkpppDFpseg 388
                   + +sa e+ e     ++ +++l  iP +++GDy++    ++h  ++ ++ ++ +sv+Y +     + n + +++ +++  r + p DF + +
  EFC39135.1 151 --QLNSADEMVEYVRNIVKEHDRLEYIP-IKKGDYIFFDNRTAHRNSDANDMNRPRSVFYHAYSCAHKVNYQTIKQLQEKRKRFEHPDDFGT-K 240
                 ..566778888888888899999999*9.8************************************************************95.3 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 6.9e-07
                 HHHHHHHHHHTEEEEETSS-HHHHHHHHHHHHHHHHHT.............SSHHHTTSSS-CEE-----HHHHHHHCSHHH.HHHHHHHHTTSB.... CS
     DUF1479  65 aefsaeikrrGvlvvrgvvpeeeaeewkeeikeYlekn.............sdikglpkekpqiyelyWskaqvkaRahpnv.laaqkflnslwe.... 145
                 + + + ++r+G +vv ++v   + +++  e+ +Y +               +++ ++  +  ++ e+y+ + q + R++p + +a+ k l + w     
  EFC39135.1 298 QRHIDFFHRFGYVVVENIVTDADCDQLLVELCHYSTLAgcpisvngksvsqNQFAKIGGNFGAMVEFYYLPMQQQLRMSPALyTATVKLLTNTWCsttp 396
                 56777899***************************9999**********96669**************************98256789999***96666 PP

                 ......-E.TTEESSEEEEE------EEEE-T CS
     DUF1479 146 ......se.dekkrislatpitYaDrlrirkp 170
                        e     +i++++   Y Dr+  r p
  EFC39135.1 397 nawnvpYEcPLAPHIDPRKLWLYVDRMNFRLP 428
                 66655533345667888888888888888776 PP

>> PhyH  Phytanoyl-CoA dioxygenase (PhyH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.24   8.8e+02     112     146 ..      45      82 ..      40      83 .. 0.84
   2 !    9.3   0.0   0.00035       1.3     176     204 ..     169     198 ..     138     205 .. 0.78
   3 !    7.8   0.0     0.001       3.6       1      24 [.     304     327 ..     304     353 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.24
                 SGGGST...EESGCCEEEEEEESS-B-TTBT-EEEETT CS
        PhyH 112 Dstflp...tdpeesvvgvwialedateenGclrfiPG 146
                 D t+ p   ++p +s+v++       ++++G+l +iPG
  EFC39135.1  45 DFTYGPldrFRPFQSMVCLTDGCVNRHKKEGGLEVIPG 82 
                 788888777777899999999999999**********9 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00035
                 GSCEEEE.BTTTEEEEEETTSEEE.E-TB. CS
        PhyH 176 eeeavpvevkaGdavlfhgrllHg.sgaNr 204
                  ++   +++k+Gd ++f+ r++H+ s aN 
  EFC39135.1 169 HDRLEYIPIKKGDYIFFDNRTAHRnSDAND 198
                 556777899**************7366665 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.001
                 HHHHSEEEETTSS-HHHHHHHHHH CS
        PhyH   1 feedGylviegflsaeevealrae 24 
                 f++ Gy+v+e+ ++++ +++l+ e
  EFC39135.1 304 FHRFGYVVVENIVTDADCDQLLVE 327
                 89******************9765 PP

>> UBA_6  UBA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.89   3.2e+03      30      40 ..     121     131 ..     117     132 .. 0.84
   2 ?   11.8   0.1   4.7e-05      0.17       2      38 ..     298     328 ..     297     331 .. 0.92

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.89
       UBA_6  30 dedkvLsELIk 40 
                  edk L EL++
  EFC39135.1 121 EEDKPLYELVR 131
                 68999*****8 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 4.7e-05
       UBA_6   2 qskldfflKLGYseeqvqavLekLGpeadedkvLsEL 38 
                 q ++dff++ GY       v e++ ++ad d++L EL
  EFC39135.1 298 QRHIDFFHRFGY------VVVENIVTDADCDQLLVEL 328
                 689*********......599***************9 PP

>> DUF2097  Uncharacterized protein conserved in archaea (DUF2097)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.5   2.3e-05     0.083       6      25 ..     154     173 ..     150     175 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.3e-05
     DUF2097   6 taeelieYiknnvkegdile 25 
                 +a+e++eY++n vke+d le
  EFC39135.1 154 SADEMVEYVRNIVKEHDRLE 173
                 689***************98 PP

>> MCRA  MCRA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   3.7e-05      0.13     243     322 ..     161     242 ..     146     301 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 3.7e-05
                 EEEEEEEEE.TTEEEEEE--TTEEEEEE---SSTT-EE-BTTB------.--....-HHHHHHHHHHCC-GGG--THHHHSS-- CS
        MCRA 243 tvteielekeegeeetieleedDlvfvtnGsitessslGdndtpakleekea....desweLWkklaakspkfGnPekFcsdie 322
                  v++i  e+  ++ e i +++ D++f+ n     +s+  d+++p ++  ++     + + +  k+l++k+++f +P+ F ++ +
  EFC39135.1 161 YVRNIVKEH--DRLEYIPIKKGDYIFFDNRTAHRNSDANDMNRPRSVFYHAYscahKVNYQTIKQLQEKRKRFEHPDDFGTKFR 242
                 344444443..46678***************************997765444577789999******************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (430 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       459  (0.025601); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.62u 0.27s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 2756.24
//
Query:       EFC39136.1  [L=1993]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.1e-17   63.5   1.1    6.3e-17   61.9   1.1    1.8  1  Peptidase_M16    Insulinase (Peptidase family M16)
    1.8e-14   54.2   2.3    5.3e-11   42.9   0.1    3.5  3  Peptidase_M16_C  Peptidase M16 inactive domain


Domain annotation for each model (and alignments):
>> Peptidase_M16  Insulinase (Peptidase family M16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.9   1.1     7e-21   6.3e-17       1     128 [.     160     294 ..     160     307 .. 0.87

  Alignments for each domain:
  == domain 1  score: 61.9 bits;  conditional E-value: 7e-21
                    EEEEEE-TSSSEEEEEEEES-SGGGSCTTTTTHHHHHHHHTTSBBSSSCH.HHHHHHHHHTT.CEEEEEEESSEEEEEEEEEGGG.....HHHHHH CS
  Peptidase_M16   1 rvalesdppaktsavglvvdaGSryepkdlnGlAHllehmafkgTkkyps.nklaeeleklG.gslnAttsrentvYyvevlskd.....lekald 89 
                    +v+++++ ++k+ ++ l v +GS +e++  +G++H++ehmaf ++k +++  ++ + +e+ + g +nA+ts + tvY +   + d     +e+++d
     EFC39136.1 160 YVLMKNTFNKKRFSALLHVYTGSVNEEESEQGISHMVEHMAFDNSKSFKGrGGVWRKIENSNvGGFNAFTSFRSTVYELLENKIDdtkesFEDIMD 255
                    688999999*****************************************9*******99775889***********8633333345577****** PP

                    HHHHHHHSBTTSHHHHHHHHHHHHHHHHHHCCHHHHHHH CS
  Peptidase_M16  90 vladvfkaplleesevererkvvekeveavdaepekvve 128
                    ++   +++++   ++ve+e+ +v+ e   +++ + ++++
     EFC39136.1 256 IFFAQVQQSEYVAEYVETEKGAVLGEARRANNSYYHALT 294
                    *********************999999888888744444 PP

>> Peptidase_M16_C  Peptidase M16 inactive domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.9   0.1   5.9e-15   5.3e-11       1      60 [.     321     381 ..     321     417 .. 0.79
   2 !    8.2   0.0   0.00026       2.3      18     119 ..     897    1009 ..     896    1080 .. 0.61
   3 ?    0.4   0.1     0.062   5.6e+02     111     167 ..    1178    1232 ..    1164    1242 .. 0.79

  Alignments for each domain:
  == domain 1  score: 42.9 bits;  conditional E-value: 5.9e-15
                      CH-HHHHHHHHHHHSSGGGEEEEEEESS-HHHHHHHHHHHHTTSTHHSH.CSGSCTSSSSS CS
  Peptidase_M16_C   1 sltredlkefykkfYrpenmvlaivGdvdheelvkliekyfgdlkaska.ppakptgeplt 60 
                      s+t++dlk++y+k+Y+ +nm+l+ivGd++ +el+k++++y ++  ++ + +p++ + ++ t
       EFC39136.1 321 SWTVNDLKKYYDKWYKLSNMKLYIVGDFELDELEKMVKEYWSSKVSTVEnKPEEAKIGFAT 381
                      69************************************99887665543334444444444 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00026
                       GGEEEEEEESS-HHHHHHHHHHHHTTSTHHSH.........CSGSCTSSSSSGGGSSEEEEEEEES.......SSSSEEEEEEEEEECTCTH CS
  Peptidase_M16_C   18 enmvlaivGdvdheelvkliekyfgdlkaska.........ppakptgepltpatlkkppvvlkkl.......deeqahlslafegpskend 93  
                       +++++ ivGdv+ + ++ ++e  fg+++ + +          +++ +++ +t   +k++p v+            e+a ++  ++ ++ +  
       EFC39136.1  897 NRFEINIVGDVSIDNIMPQLETWFGSIPVKQKptivgfdlyDKNQASNFEVT--FPKTSPLVNSTYscevnsyAGEKALVTAIYPIKGANAA 986 
                       578899**********************876566666665533333333333..33333333222244444443355666666666666555 PP

                       TTHHHHHHHHHHHHSSTTSHHHHHHH CS
  Peptidase_M16_C   94 eddlalavlntlLgggmesrLytnlr 119 
                         +l  a+l++ L+++     +  +r
       EFC39136.1  987 NPSLSRALLQQALLSA---YSFEVIR 1009
                       5666666666666666...4455555 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.062
                       TSHHHHHHHTTTTSESEEEEEEEEESSCEEEEEEEEEECTTHHHHHHHHHHHHHHHH CS
  Peptidase_M16_C  111 esrLytnlrekeglaysvsafndsyrdsglfgisatadpenveevvevilkelrklk 167 
                       +sr y n    ++ ++  +++n+ +r  ++++ ++ a+ +n+e+v++  l++ +  +
       EFC39136.1 1178 YSRHYGNTN--SNTTTTSNSYNRENRRVTILYTHIPAQYQNTEPVIQKSLNTTDSKT 1232
                       555555555..77778889999999999999999999999****9998888766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1993 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1450  (0.0808746); expected 358.6 (0.02)
Passed bias filter:                      555  (0.0309554); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.23u 0.31s 00:00:01.54 Elapsed: 00:00:00.50
# Mc/sec: 11925.63
//
Query:       EFC39137.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.5e-11   42.2   2.2    8.8e-11   42.2   0.4    2.0  2  TLD       TLD


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.15   2.7e+03      55      65 ..      43      53 ..      15      66 .. 0.53
   2 !   42.2   0.4   4.9e-15   8.8e-11       1      90 [.      71     167 ..      71     221 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.15
         TLD 55 dsesflfslsp 65
                +++s l ++++
  EFC39137.1 43 KNNSKLLNYHQ 53
                23333333333 PP

  == domain 2  score: 42.2 bits;  conditional E-value: 4.9e-15
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl.spkfkvyks...tgknkaylntssdg...lgfG 90 
                 lly++s+dg+sl+++++ ++++  +++++k++ +++fG++++++++ +++++++d+e f f + ++kf  ++      + + y + +sd    ++fG
  EFC39137.1  71 LLYRASRDGFSLKSFHKYCDDHFKVVIIVKSKAGDLFGGYTTKNLRLDGDRNVNDDELFTFRFeNDKFYAFRLqpvYRDHALYRYEESDApylFAFG 167
                 79*************************************************************9999999998333233355555555446667777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1361.32
//
Query:       EFC39138.1  [L=489]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (489 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2666  (0.148698); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.99u 0.36s 00:00:01.35 Elapsed: 00:00:00.56
# Mc/sec: 2651.75
//
Query:       EFC39139.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0067   17.0   0.1       0.01   16.4   0.1    1.4  1  DUF4773   Domain of unknown function (DUF4773)
  ------ inclusion threshold ------
      0.033   13.7   0.1      0.051   13.1   0.1    1.2  1  HRXXH     Putative peptidase family


Domain annotation for each model (and alignments):
>> DUF4773  Domain of unknown function (DUF4773)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.1   1.1e-06      0.01      16      96 ..      82     160 ..      59     167 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.1e-06
     DUF4773  16 nlkalklkkkvCvnvkynpedlslkvkvslnekvllkktis..aknpppiCvplleklakvCvrlsdikakeenlkaClelea 96 
                  lk++k++++v +      +++++++kv+ ++k+l++k+++    n  piC+++l + + +Cv++ +i++   + ++C ++++
  EFC39139.1  82 VLKKIKVSGTVTM--VAYLTRQKVQLKVETGGKTLFDKEFDmgLVNLDPICLDFLLD-IGFCVQVRNIRFDI-KGEGCAAFDI 160
                 4455555554443..333455589************998874478*********755.99********9764.4467777765 PP

>> HRXXH  Putative peptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   5.7e-06     0.051     142     170 ..      68      95 ..      56     102 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 5.7e-06
       HRXXH 142 detviCdlsyetrkslselCaeGytvaes 170
                 ++t iCd+sye++ +l+++  +G tv+ +
  EFC39139.1  68 TKTFICDVSYEKKLVLKKIKVSG-TVTMV 95 
                 689********************.88765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 1111.53
//
Query:       EFC39140.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       997  (0.0556082); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.36s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 2850.97
//
Query:       EFC39141.1  [L=724]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.021   14.5   0.2      0.049   13.3   0.2    1.6  1  BAR_3     BAR domain of APPL family


Domain annotation for each model (and alignments):
>> BAR_3  BAR domain of APPL family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.2   2.7e-06     0.049      93     141 ..     289     337 ..     272     393 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.7e-06
       BAR_3  93 lldqaqrsikkpLekFrkedlkevkekkkkFdkesekleaaleknaqls 141
                 +++ +q+++k+ L++F ++++++++e + +F k s+++e+  e+   ++
  EFC39141.1 289 YVKVTQDNLKNVLQQFFQDHISKLQEICSAFTKRSSSYESPFERPWIIP 337
                 667799*********************************9888765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (724 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       639  (0.0356406); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 4171.66
//
Query:       EFC39142.1  [L=1340]
Description: hypothetical protein NAEGRDRAFT_59353 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-18   66.5   5.0    3.5e-05   23.5   0.0    4.9  5  DUF4116      Domain of unknown function (DUF4116)
    2.2e-06   27.2   3.1    4.1e-06   26.3   0.5    2.6  2  Pkinase_Tyr  Protein tyrosine kinase
    3.2e-06   26.7   0.6    3.2e-06   26.7   0.6    3.0  3  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
        2.2    8.4  11.3        4.6    7.4   0.4    3.9  4  CIDR1_gamma  Cysteine-Rich Interdomain Region 1 gamma


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.2   3.8e-08   0.00017      13      49 .]     350     386 ..     338     386 .. 0.89
   2 !   22.5   0.2   1.5e-08   6.8e-05       3      49 .]     390     436 ..     388     436 .. 0.98
   3 !   23.5   0.0   7.7e-09   3.5e-05       3      43 ..     415     455 ..     413     461 .. 0.87
   4 !   13.2   0.1   1.3e-05     0.057       1      45 [.     438     482 ..     438     485 .. 0.95
   5 !   15.4   0.0   2.6e-06     0.012       3      44 ..     465     503 ..     463     507 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 3.8e-08
     DUF4116  13 gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                  +al+y s +L n+k+++ k +++n++a+++a+e Lr
  EFC39142.1 350 EFALEYNSFSLANNKNFMQKLIEINPIAFKFAHETLR 386
                 5788898889************************998 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 1.5e-08
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 E+v  +++k+   lky+ ++L++  e++ k ++++g  l ya e+L+
  EFC39142.1 390 EFVEMVLEKDVHLLKYVHSDLTSKTEFMEKYIRKDGLLLQYAAEHLK 436
                 9*****************************************99997 PP

  == domain 3  score: 23.5 bits;  conditional E-value: 7.7e-09
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsy 43 
                 E++ ++++k+g+ l+y+ e Lk +k++v+ A     +a+ +
  EFC39142.1 415 EFMEKYIRKDGLLLQYAAEHLKWNKDFVKIATDETACAIMH 455
                 9****************************997666666655 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 1.3e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 ++++v+ a +   +a+ ++ +++   ++++++++k+n++ l+ya 
  EFC39142.1 438 NKDFVKIATDETACAIMHVTNKFDGYIDLLKECLKRNPHLLEYAL 482
                 79*****************************************95 PP

  == domain 5  score: 15.4 bits;  conditional E-value: 2.6e-06
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 ++ +e++k+n+  l+y+ e+    ++ivl Av q+++ + ya
  EFC39142.1 465 DLLKECLKRNPHLLEYALEK---TIDIVLCAVSQDPITIGYA 503
                 899*************7665...**************99998 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   0.5   9.2e-10   4.1e-06       6     251 ..     119     350 ..     116     353 .. 0.70
   2 ?   -0.8   0.1      0.17   7.6e+02      15     100 ..     770     856 ..     765     895 .. 0.67

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 9.2e-10
                  EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH..HHHHHHHHHHHHTS.-BTTB--EEEEEESSSSEEE..EEE--TTEBHHHHHHHTCTT CS
  Pkinase_Tyr   6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateee..keelleeakimkkl.khpnivkllgvctkeeplli..vteyvkgGdLlkfLrkkeke 98 
                  + G+G+ ++ + + +k        kV++K+ k  ++e +   e+++  ++  +++ + ++ ++++ ++ k+ + ++   + + ++GdL++       +
   EFC39142.1 119 SYGKGQRSHLYTALWK------GKKVVIKITKGPKKEVKreVEKVM-LLENCSNIiSYERAIEFMDAYDKDFQSYMgyHMVFYPNGDLSNI-----PK 204
                  5699999999999999......889999999644433321122222.33444444478888899999987776666225668899**9986.....45 PP

                  TSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHH...HHHHHHH CS
  Pkinase_Tyr  99 kltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsks...DvWsfGv 193
                  +l+  + l +a+ +A+ +eyL++++ vH dl   N L+  +kv++  D  + + i  d ey ++ ++ +     + E+l+++k++ ++   D   fG 
   EFC39142.1 205 PLSEISFLIIAMRMASIIEYLQQMEHVHYDLKLSNFLIG-SKVIRGYDV-IYDPILIDLEYAASLTSLI----KSKETLTKSKIQNQAfaeDLKNFGD 296
                  7899999*******************************9.567765554.3333323333443333333....355666666655443333******* PP

                  HHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS-- CS
  Pkinase_Tyr 194 llwEiftlgespypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRpt 251
                  +l E++++ge+   + + +e+++k++e+   e p +++e    ++k+      + Rp+
   EFC39142.1 297 CLLELYSHGENWKYQNELKELINKIQEESSKEIPLNITE----ILKSFTIMAFTIRPE 350
                  **********99999999999999999998888886555....555555555555555 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.17
                  EEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr  15 VvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvct..keepllivteyvkgGdLlkfLrkkekekl 100
                  V+e    + ++++  k ++K++ ++++e+  ++l++   + k+   h+  ++     +  k + ++i+ e+  +G+++ + +++  +k+
   EFC39142.1 770 VYETVFFSVNNEAIFKKVIKQMWKQQKESVDKDLTQSDLTCKTSeGHEITINSSRSDLweKINDVFIIEEFDGQGHVSRYFERD--NKI 856
                  555555555566666777888877777776777766444444443666666665444444667799999999999999999887..222 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.6   7.2e-10   3.2e-06       3     135 ..     116     245 ..     114     284 .. 0.76
   2 ?   -3.0   0.0      0.83   3.7e+03     226     249 ..     452     475 ..     378     476 .. 0.69
   3 ?   -0.1   0.6      0.11   4.8e+02      15     106 ..     774     867 ..     768     874 .. 0.76

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 7.2e-10
                 EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.......CTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHHHH CS
     Pkinase   3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.......hpnivrlyevfee..kdelylvleyveggeladllerk 92 
                 +l+  G+G+ +  y a+  ++gk+v++K+ k  k++ k+e      ++ +  l+        ++ +++++++ +  ++++   + + ++g+l ++ +  
  EFC39142.1 116 DLKSYGKGQRSHLYTAL--WKGKKVVIKITKGPKKEVKRE------VEKVMLLEncsniisYERAIEFMDAYDKdfQSYMGYHMVFYPNGDLSNIPK-- 204
                 56778************..9********999887766554......443333333001112555556666666665555556788889999*99997.. PP

                 SS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTT CS
     Pkinase  93 gslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekg 135
                   lse     ia ++++ +eyl +++ +H DlK +N+Li + +
  EFC39142.1 205 -PLSEISFLIIAMRMASIIEYLQQMEHVHYDLKLSNFLIGS-K 245
                 .6*************************************83.3 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.83
                 ..HHHTTS-HHHHHHHHHHT-SSG CS
     Pkinase 226 klpeaseiseeakdllkkllkkdp 249
                 ++ + ++  +  +dllk++lk++p
  EFC39142.1 452 AIMHVTNKFDGYIDLLKECLKRNP 475
                 333444445667888888888887 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.11
                 EEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--E..EEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHH CS
     Pkinase  15 VykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrl..yevfeekdelylvleyveggeladllerkgslseeeakkiakq 106
                 V+  v++e   + ++K++ k+++++ +++ +++ ++   +  h+  ++    + +e+ ++++++ e+  +g++ ++ er+ ++++ e+++i ++
  EFC39142.1 774 VFFSVNNEAIFKKVIKQMWKQQKESVDKDLTQSDLTCKTSEGHEITINSsrSDLWEKINDVFIIEEFDGQGHVSRYFERDNKITKLEIEHIRSN 867
                 5555555555666788888888888887777788777777779988876225789999**************9999998888888888777555 PP

>> CIDR1_gamma  Cysteine-Rich Interdomain Region 1 gamma
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       1.8   7.9e+03      14      29 ..     629     644 ..     626     647 .. 0.77
   2 ?    6.5   0.4     0.002       8.8      21      41 ..     756     796 ..     739     805 .. 0.69
   3 ?    7.4   0.4     0.001       4.6      15      40 ..    1051    1074 ..    1044    1081 .. 0.76
   4 ?   -3.0   0.0       1.8     8e+03      21      35 ..    1112    1128 ..    1097    1129 .. 0.58

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.8
  CIDR1_gamma  14 fikeylknlfkesrLF 29 
                  +++ +  +lfk+ +LF
   EFC39142.1 629 NFDSESAELFKTPCLF 644
                  5667777799999998 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.002
  CIDR1_gamma  21 n....................lfkesrLFkgirkQkWkCkf 41 
                                       + ++  +Fk++ kQ Wk ++
   EFC39142.1 756 CmtsqdqepevksavyetvffSVNNEAIFKKVIKQMWKQQK 796
                  4555555566666666688888999************9666 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.001
  CIDR1_gamma   15 ikeylknlfkesrLFkgirkQkWkCk 40  
                   ++++++n   + +L+k++ +Q W C 
   EFC39142.1 1051 VNNNIHN--DSDSLLKSFNDQTWSCM 1074
                   5555555..6789************6 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 1.8
  CIDR1_gamma   21 n..lfkesrLFkgirkQ 35  
                   +  + + s+LF++ + Q
   EFC39142.1 1112 SlkDATISDLFQSNSHQ 1128
                   24457789999998877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1468  (0.0818785); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.91u 0.30s 00:00:01.21 Elapsed: 00:00:00.50
# Mc/sec: 8089.12
//
Query:       EFC39143.1  [L=301]
Description: translation initiation factor eIF-2B alpha subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-50  172.4   0.0    1.3e-50  172.2   0.0    1.1  1  IF-2B       Initiation factor 2 subunit family
  ------ inclusion threshold ------
      0.056   13.1   0.0       0.12   12.0   0.0    1.6  1  Catalase_C  C-terminal domain found in long catalases


Domain annotation for each model (and alignments):
>> IF-2B  Initiation factor 2 subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  172.2   0.0   1.5e-54   1.3e-50      32     282 .]      19     289 ..       1     289 [. 0.90

  Alignments for each domain:
  == domain 1  score: 172.2 bits;  conditional E-value: 1.5e-54
                 HHHHHHHHHHHHTSSTS-HHHHHHHHHHHHHHHCCTTTSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTC.-TTEEEEEES.--SHHHHHHHH.H CS
       IF-2B  32 keelrkaidlLkkarPtavslgnairrllkeiselksssdvkeakksliekikelikeieeadekigdiaaeli.kdgdtilTic.nsktvlevlra.a 127
                 ++el++   + +++ P+   +    r++++  +  ++ +d k+++k+l e+ +e++    +a+e i +  + ++  d++ ++ ++ +s+tv++vl   a
  EFC39143.1  19 RHELKDFPLFFQSSIPLRSACELYRRFVTR--RLTEEITDFKACRKRLTERGNEIQLVSAQAKERITELFRPFFsRDNMKVMIVGgYSETVISVLTGiA 115
                 566666667778888888888888888888..677999************************************889999999988****998887655 PP

                 HHTT....EEEEEEEEEXTTTTHHHTHHHHHHHTTXEEEEEEGGGHHHHHHC.TESEEEEEXSEEETTSEEEEETTHHHHHHHHHHTTXEEEEEXXGGG CS
       IF-2B 128 akek....kkfkVivvEsrPrlqGrltakeLvqagipvtlitdsavayvmse.evdkvivGAdrilenGaiankiGTsslAvlAkefnipvlvvaeslk 221
                    +    +  +V+v E+rP+ +G  +ak L+  +ipvt+itd+++ay ms  + d v+ GA++++e G+i+nkiGT++ A+lAke++ p++v+ae ++
  EFC39143.1 116 TYMQqsayRFKSVLVPEGRPDGSGYRLAKALSSCNIPVTIITDASIAYHMSShDLDFVLTGAEGVVESGGIINKIGTYQAAILAKEHKKPFYVAAERFR 214
                 443334445667*************************************************************************************** PP

                 BESTSSSGGGSSXXBEXTHHHHEETTEESSTT..............TEEEEEBSEEEEEGGGXSEEEETTEEEXC CS
       IF-2B 222 fservqldedifieerdpeellnitgeriaee..............elkvvnpafDvtPpelItliITevGvlpp 282
                 f ++++++++++ e++++  +++i++++++                ++++ np+ D tPp++It+++T++G+++p
  EFC39143.1 215 FARQYPVNQKDILELEEKGWIYYINKPEFKMIpalgfedesvlesdSIQISNPTSDFTPPKYITMLFTDFGIMTP 289
                 **************************99855599***************************************98 PP

>> Catalase_C  C-terminal domain found in long catalases
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   1.4e-05      0.12      23      94 ..      86     158 ..      67     164 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.4e-05
  Catalase_C  23 laaalaaegvdvtvvaeklgsaegv.n..rTYstadaveFDaivvadgaeslfsakataasslfpagrplqllld 94 
                 ++  +++++++v +v+   ++  +v +  +TY++ +a  F +++v +g  +        a++l + + p+++++d
  EFC39143.1  86 FRPFFSRDNMKVMIVGGYSETVISVlTgiATYMQQSAYRFKSVLVPEGRPDGSGY--RLAKALSSCNIPVTIITD 158
                 56788999*******977753344422448******************8776643..356666666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (301 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.34s 00:00:00.98 Elapsed: 00:00:00.55
# Mc/sec: 1658.97
//
Query:       EFC39144.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.2   0.0        0.3   11.0   0.0    1.6  1  SH3_9     Variant SH3 domain


Domain annotation for each model (and alignments):
>> SH3_9  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   1.7e-05       0.3       8      43 ..     209     247 ..     208     252 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 1.7e-05
       SH3_9   8 redde.LsLqrGDvitvieesedgWlegs..ltGrtGlv 43 
                 r++d+ Ls+  GDv+t+  +++  +++g+  +++++G v
  EFC39144.1 209 RKQDWkLSIAGGDVFTLKFKENTKYVQGTfeNGSQKGKV 247
                 678855************777*******86578899987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       668  (0.0372581); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1834.21
//
Query:       EFC39145.1  [L=587]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-52  178.1   0.2    6.4e-52  176.2   0.2    1.9  1  Copine         Copine
    3.7e-19   68.9   0.1    6.8e-09   36.0   0.0    2.7  2  C2             C2 domain
    0.00081   19.5   0.0     0.0019   18.4   0.0    1.6  1  vWA-TerF-like  vWA found in TerF C terminus


Domain annotation for each model (and alignments):
>> Copine  Copine
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  176.2   0.2   1.1e-55   6.4e-52       1     215 [.     353     576 ..     353     579 .. 0.90

  Alignments for each domain:
  == domain 1  score: 176.2 bits;  conditional E-value: 1.1e-55
      Copine   1 sLHyispeqpneYekallsvgeilqaydsdklipafGFGaklpsdaevsdefvlnfneenkevegiegvleaYrealpnlql......ygPT....... 86 
                 sLH ++++++n+Y++al +v++il++ydsdk+++a+G+Ga + ++++++  f+l++++++ e +g e++l aY +a+p+l+       + P        
  EFC39145.1 353 SLHHLNAKNKNDYQQALEQVLHILEPYDSDKMYGAYGYGATIEKESKMHPMFNLSLSDKE-ELCGAEEILDAYVKAVPKLSFgdmgsaTNPKtgkayrg 450
                 8******************************************************98765.5669***************7533222222312333333 PP

      Copine  87 .nfapviekvakiaeasakeasqYfvLliitDGvvtdmketidaivaAsklplSiiivGvGdadfekmreldddd.alkssdgriakRdivqfVdfrdl 183
                  +f  vie+v+++    +++++ Y +Ll+i DG   dm+ tid+iv+A + p+SiiivGvGd+ f + r++d+dd  l +s+g+ ++RdivqfV f++ 
  EFC39145.1 451 dDFYRVIEHVVEKTPPITQHQQFYNILLLIIDGDAFDMQGTIDSIVEANDKPISIIIVGVGDSRFPSCRKFDADDePLVHSNGKKMTRDIVQFVSFSKC 549
                 3699**********************************************************************999********************** PP

      Copine 184 ksnasakeaalakavLaeiPkqlkaylelrkl 215
                  +      ++la++vLaeiPkq+++y+e++++
  EFC39145.1 550 SN-----LTELASEVLAEIPKQMVTYFESKGV 576
                 99.....999*****************99876 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.0   7.8e-11   4.7e-07      20      85 ..       3      81 ..       1      96 [. 0.87
   2 !   36.0   0.0   1.1e-12   6.8e-09      11      97 ..     173     265 ..     163     269 .. 0.83

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 7.8e-11
                SSCEEEEEEEE.............ECEEEEEE-SCSSSSSSEEEEEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEE CS
          C2 20 gssdpyvkvsl.............dgkqkakTrviknslnPvWnekftfevaeleeakLeveVfdndrlskddfiGkve 85
                ++sdp++k+++             d +  + T++i+n+ nPv++ kf+++ +++  +kL +e+fd+d+ +++ +iGk++
  EFC39145.1  3 SKSDPFAKLYYsgpqensqtlistDFSCLGSTETIQNNHNPVFKTKFSVHYYFECVQKLYIEIFDEDTGNSNRLIGKTK 81
                579999999998888877777777777778888899999**************9**************99999***985 PP

  == domain 2  score: 36.0 bits;  conditional E-value: 1.1e-12
                 ESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEEEEEEEEESC...HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHHH CS
          C2  11 knLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWnekftfevae...leeakLeveVfdndrlskddfiGkveiplstllsgeea 97 
                  +L +kd  g+sdpy   +     ++   + ++vi ++lnP W   f+++++e   + ++++ v++fd+d++skdd+iG++++ l+++l+++++
  EFC39145.1 173 IGLDKKDLLGKSDPYFYFEKdvagRRVPLYTSEVICKTLNPSW-LPFKINLDEfnnDYQKEIFVKCFDKDKFSKDDLIGEFRFTLDQVLNNKVK 265
                 46799999******9888777786667778888**********.5666666666689******************************8877765 PP

>> vWA-TerF-like  vWA found in TerF C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   3.1e-07    0.0019      67     154 ..     415     523 ..     353     567 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.1e-07
  vWA-TerF-like  67 v...................keeeegllelkklggvneeapvleevlekvrk..epaelptlvlFitDGgvkkkkeiekalreaskepiFwqFvgl 141
                    +                   +  ++ + ++ k+ +  +  +v+e+v+ek     ++++   ++l i DG++ + + + + + ea ++pi    vg+
     EFC39145.1 415 CgaeeildayvkavpklsfgDMGSATNPKTGKAYRGDDFYRVIEHVVEKTPPitQHQQFYNILLLIIDGDAFDMQGTIDSIVEANDKPISIIIVGV 510
                    344455555555555554442222222334455556788999***999987543566677888999****************************** PP

  vWA-TerF-like 142 gkseygvLeklDd 154
                    g+s++   +k+D 
     EFC39145.1 511 GDSRFPSCRKFDA 523
                    **********996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (587 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 3375.33
//
Query:       EFC39146.1  [L=899]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.1e-50  169.8   2.2    5.1e-50  169.8   0.1    2.1  3  Pro_isomerase  Cyclophilin type peptidyl-prolyl cis-trans iso
    7.3e-05   23.0   0.0     0.0096   16.2   0.0    3.7  3  ANAPC4_WD40    Anaphase-promoting complex subunit 4 WD40 doma
      0.001   19.8   2.7         31    5.7   0.1    4.5  4  WD40           WD domain, G-beta repeat
     0.0024   17.5  14.3     0.0024   17.5  14.3    2.6  2  SR-25          Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> Pro_isomerase  Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       3.5   1.6e+04     101     116 ..     194     209 ..     184     231 .. 0.70
   2 ?   -4.2   0.0         4   1.8e+04      94     114 ..     612     630 ..     604     636 .. 0.71
   3 !  169.8   0.1   1.1e-53   5.1e-50       2     150 ..     729     872 ..     728     880 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3.5
  Pro_isomerase 101 nsagsqFfItlkeaph 116
                      ++++F It+++  h
     EFC39146.1 194 SHSSTHFIITMSKDGH 209
                    3456677777765444 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 4
  Pro_isomerase  94 artgkepnsagsqFfItlkea 114
                    +++  ++ns+gs  ++t+++ 
     EFC39146.1 612 HNA--SKNSNGSSQMFTMGDS 630
                    444..5799988888887765 PP

  == domain 3  score: 169.8 bits;  conditional E-value: 1.1e-53
  Pro_isomerase   2 vdietsskGrivieLfadkaPktvenFlklvkegfYdgttFhRvikgfmvqgGdptgktsageqekkggesi..raipdEitsklkh.krGalama 94 
                    ++i+ts  G+i+++Lf+d +PktvenF +l  +g+Yd+++FhRvik+fm+q+Gd ++ +  g    +gg+si  ++++dE++++lkh ++G l+ma
     EFC39146.1 729 ATIHTS-FGDIQVKLFPDVCPKTVENFTQLSLNGYYDNCIFHRVIKNFMIQTGDNDNRD--G----TGGTSIfgKEFEDEFSPSLKHdRPGKLSMA 817
                    579996.***********************************************54442..3....3555555579******99***888****** PP

  Pro_isomerase  95 rtgkepnsagsqFfItlkeaphldgkytvFGkVveGmdvvekiekvetde.erpkkn 150
                    ++g  p +++sqFfIt+ ++p+ld+k+t FG+V++Gm+vv +ie+v+tde erp+  
     EFC39146.1 818 NRG--PGTNSSQFFITTVPTPWLDNKHTLFGEVIKGMEVVHSIESVPTDEfERPVLH 872
                    *98..8********************************************9888754 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.13   5.9e+02      50      81 ..     245     276 ..     196     282 .. 0.70
   2 ?   -1.2   0.0      0.56   2.5e+03      49      71 ..     299     321 ..     291     351 .. 0.70
   3 !   16.2   0.0   2.1e-06    0.0096      29      77 ..     403     449 ..     385     457 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.13
  ANAPC4_WD40  50 gklLavaysdgevrlldaesgkvvhslsvkse 81 
                  + lLa ++  + ++++d+ + ++++ +s ++ 
   EFC39146.1 245 DGLLAASMTRSDLKVYDVTNFDMINVFSFTKP 276
                  56888888888889999988888888877665 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.56
  ANAPC4_WD40  49 dgklLavaysdgevrlldaesgk 71 
                   +k+L + ++dg+++++d  + +
   EFC39146.1 299 TDKILGIFFEDGAIEFYDPCNPD 321
                  57899999999999999865554 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 2.1e-06
  ANAPC4_WD40  29 vwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhsls 77 
                  +++l  +k++    sL  ++dgk ++v + dg+vr++d  sgk+v+ ++
   EFC39146.1 403 LFEL--AKQKTYAISLDISKDGKSFVVLCRDGHVRVFDFLSGKMVRDYD 449
                  5555..566777789999***************************9875 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.1    0.0069        31      18      37 ..     194     213 ..     179     214 .. 0.71
   2 ?   -2.0   0.0       1.8     8e+03       4      13 ..     223     233 ..     221     238 .. 0.80
   3 ?    5.0   0.0     0.011        51      10      38 .]     340     369 ..     333     369 .. 0.86
   4 !    5.6   0.0    0.0071        32      15      38 .]     415     438 ..     405     438 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0069
                 EETTSSEEEEE.ETTSEEEEE CS
        WD40  18 fspdgawlasG.sdDgtvriW 37 
                  +++ ++++   s+Dg+v++W
  EFC39146.1 194 SHSSTHFII-TmSKDGHVKFW 213
                 455555566.4489******* PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.8
                 EEEEESS.SSE CS
        WD40   4 lrtltGH.ssv 13 
                 ++++t+H +sv
  EFC39146.1 223 VKHFTAHnTSV 233
                 799****6656 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.011
                 S.SSEEEEE.EETTSSEEEEEETTSEEEEEE CS
        WD40  10 H.ssvtsla.fspdgawlasGsdDgtvriWd 38 
                 H s +t+++ +s  ga++ s++++g +  W+
  EFC39146.1 340 HrSKITCCKfNSVFGAMI-SCDEKGMIEYWN 369
                 8777****9888888886.8999*****998 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.0071
                 EEEEETTSSEEEEEETTSEEEEEE CS
        WD40  15 slafspdgawlasGsdDgtvriWd 38 
                 sl+ s+dg+ ++  ++Dg+vr++d
  EFC39146.1 415 SLDISKDGKSFVVLCRDGHVRVFD 438
                 7889999999875466******98 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5  14.3   5.3e-07    0.0024      61     136 ..       2      74 ..       1     100 [. 0.53
   2 ?   -5.0   9.9         4   1.8e+04      62      93 ..     112     137 ..      77     157 .. 0.54

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 5.3e-07
       SR-25  61 rrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkakekakaeaaaaealpgpsld 136
                 +r++sssssss ssssss+ sss s+dd +++ kkk++ +++  k   +   k   +e  ++e+++ e   gp++ 
  EFC39146.1   2 KRRNSSSSSSSYSSSSSSALSSSESDDDFERQLKKKRQLEEQIAK--LNTAVKSDDQEV-NNEEEEDEDDYGPAIP 74 
                 456788888888888888888888888866555544443333333..344444444432.2222222222333332 PP

  == domain 2  score: -5.0 bits;  conditional E-value: 4
       SR-25  62 rssssssssssssssssssssssssddrkkrg 93 
                 ++ss + ssss   ++ssss+++ +       
  EFC39146.1 112 NQSSLAVSSSSDGIEASSSSIQQQE------I 137
                 2233333333333333333333222......2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (899 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1372  (0.0765241); expected 358.6 (0.02)
Passed bias filter:                      591  (0.0329634); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.51
# Mc/sec: 5290.66
//
Query:       EFC39147.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.8e-35  117.8  11.1    1.6e-09   37.3   0.1    6.3  6  NHL           NHL repeat
      2e-19   69.9  12.6    1.3e-09   37.7   0.1    3.8  4  DUF5128       6-bladed beta-propeller
    1.6e-12   47.6   0.1    2.1e-10   40.6   0.1    3.7  2  SGL           SMP-30/Gluconolactonase/LRE-like region
      3e-08   33.8   0.6     0.0074   16.5   0.0    4.9  5  Arylesterase  Arylesterase
    4.8e-06   26.4   0.5      0.044   13.7   0.0    3.2  3  DUF4934       Domain of unknown function (DUF4934)
    2.4e-05   23.7   0.1      0.015   14.5   0.0    2.9  4  TolB_like     TolB-like 6-blade propeller-like
      0.001   18.7   0.4        6.3    6.3   0.0    3.1  3  m04gp34like   Immune evasion protein
     0.0025   18.0   0.3         10    6.4   0.0    4.0  4  He_PIG        Putative Ig domain
      0.008   16.3   1.4        2.1    8.5   0.0    3.9  5  Str_synth     Strictosidine synthase
  ------ inclusion threshold ------
      0.031   14.3   1.4        1.7    8.7   0.0    3.4  3  SBBP          Beta-propeller repeat
      0.032   14.2   0.0         15    5.4   0.0    3.0  3  Phytase-like  Esterase-like activity of phytase
       0.11   11.6   0.1          8    5.5   0.1    2.3  1  DUF839        Bacterial protein of unknown function (DUF839)


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.1   1.3e-06    0.0019       1      28 []      47      75 ..      47      75 .. 0.97
   2 ?    2.9   0.0     0.086   1.3e+02       7      21 ..      95     110 ..      91     113 .. 0.84
   3 !   18.7   0.1   8.5e-07    0.0013       1      21 [.     134     155 ..     134     159 .. 0.93
   4 !   15.6   0.0   8.3e-06     0.012       2      27 ..     180     206 ..     179     207 .. 0.92
   5 !   37.3   0.1   1.1e-12   1.6e-09       1      28 []     228     256 ..     228     256 .. 0.98
   6 !   27.8   0.0   1.1e-09   1.7e-06       2      28 .]     277     304 ..     276     304 .. 0.95

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.3e-06
                BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL  1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28
                fn+P +v ++     i+V+D++n+r+q F
  EFC39147.1 47 FNNPIDVKISfEHHTIFVSDNGNQRIQAF 75
                99*************************88 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.086
                 EEEE.TTTEEEEEECC CS
         NHL   7 vavd.snGdiyVaDse 21 
                  avd +++ ++V++ +
  EFC39147.1  95 MAVDhKDDSLIVTCEN 110
                 599**********966 PP

  == domain 3  score: 18.7 bits;  conditional E-value: 8.5e-07
                 BSSEEEEEEE.TTTEEEEEECC CS
         NHL   1 fnyPhGvavd.snGdiyVaDse 21 
                 ++ P+G+avd +nG+i+V+Ds+
  EFC39147.1 134 LSKPQGIAVDdTNGNIFVSDSK 155
                 678*****************85 PP

  == domain 4  score: 15.6 bits;  conditional E-value: 8.3e-06
                 SSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvqv 27 
                   P+G+ ++  ++ ++V+D +n+rvq+
  EFC39147.1 180 HAPNGIGISnRDNFLIVTDMKNNRVQI 206
                 569***********************8 PP

  == domain 5  score: 37.3 bits;  conditional E-value: 1.1e-12
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 f yP+G++vd ++G+i+V+Ds n+r+qvF
  EFC39147.1 228 FLYPTGLTVDkPTGNIIVCDSSNNRIQVF 256
                 88**************************9 PP

  == domain 6  score: 27.8 bits;  conditional E-value: 1.1e-09
                 SSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvqvF 28 
                  +P+G++++  +G++yV D++n+r+q++
  EFC39147.1 277 VNPTGLTINiRTGELYVVDNKNNRIQIY 304
                 58************************98 PP

>> DUF5128  6-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.4   3.3e-05     0.049      95     156 ..      44     106 ..      42     127 .. 0.87
   2 !   25.1   1.1   5.9e-09   8.8e-06      58     125 ..     142     206 ..     127     217 .. 0.81
   3 !   17.5   0.6   1.2e-06    0.0018      61     123 ..     190     253 ..     186     253 .. 0.92
   4 !   37.7   0.1   8.5e-13   1.3e-09      63     126 ..     241     304 ..     235     305 .] 0.96

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3.3e-05
     DUF5128  95 PgEYlqindfiidksnesIyildfmknkiltYdLegykfieekkldllv.sdvaqlekdklif 156
                 Pg++ +  d  i  +  +I++ d  +++i  +dL + +f+++++ ++++ + +++ ++d li 
  EFC39147.1  44 PGNFNNPIDVKISFEHHTIFVSDNGNQRIQAFDLFSQEFKYTIDTPDKPlYMAVDHKDDSLIV 106
                 89999999999999***********************************88788888888874 PP

  == domain 2  score: 25.1 bits;  conditional E-value: 5.9e-09
     DUF5128  58 ikvvdkrifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknkilt 125
                 + ++++ ifv D   +++   + +Gkf+r Ig +G+GP  +   n + i + ++ +++ d ++n++ +
  EFC39147.1 142 VDDTNGNIFVSD---SKVVLVSRQGKFIRHIGGEGKGPMQFHAPNGIGISNRDNFLIVTDMKNNRVQI 206
                 556789999955...45555599**********************************99999988765 PP

  == domain 3  score: 17.5 bits;  conditional E-value: 1.2e-06
     DUF5128  61 vdkrifvlDsaknnlfvFdkkG.kfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknki 123
                  d+ ++v+D+ +n++ + +k+G  f++  g++G    ++l+ +  ++dk   +I++ d+ +n+i
  EFC39147.1 190 RDNFLIVTDMKNNRVQIMSKNGdDFIYMFGKKGISNSDFLYPTGLTVDKPTGNIIVCDSSNNRI 253
                 68899*****************55**********************************988875 PP

  == domain 4  score: 37.7 bits;  conditional E-value: 8.5e-13
     DUF5128  63 krifvlDsaknnlfvFdkkGkfvrkIgaqGeGPgEYlqindfiidksnesIyildfmknkiltY 126
                 + i+v Ds++n++ vF+  G+f++  g++G+GP E ++ +  +i+    ++y++d ++n+i +Y
  EFC39147.1 241 GNIIVCDSSNNRIQVFSPRGEFIKSFGSKGNGPLELVNPTGLTINIRTGELYVVDNKNNRIQIY 304
                 679**********************************************************998 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.6   0.1   1.4e-13   2.1e-10      10     218 ..      58     264 ..      54     271 .. 0.82
   2 ?    0.5   0.0      0.25   3.7e+02       3      25 ..     280     302 ..     275     305 .] 0.62

  Alignments for each domain:
  == domain 1  score: 40.6 bits;  conditional E-value: 1.4e-13
         SGL  10 eegaLlwvDilgqrihrldpatgketv.ldtpe.svGaiaprkdgrlvvasksglall.dlasgeletladeeedekpllrfNDgvvdp.dGrlwfGtm 104
                 e+++++ +D  +qri ++d+ +++ ++ +dtp+ ++ +++++kd+ l+v+ +++ ++   l + + + l + e++e  l ++  ++vd+ +G++++ + 
  EFC39147.1  58 EHHTIFVSDNGNQRIQAFDLFSQEFKYtIDTPDkPLYMAVDHKDDSLIVTCENSCVYKySLCN-DHNLLWSLESKE-LLSKPQGIAVDDtNGNIFVSDS 154
                 47888999***********99998665499999999999999998888877777666534333.677777776566.8999999999753899****** PP

         SGL 105 gdeeakgeevgalyrldpd.gklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGlavDa.eGnvwvAv 201
                 +   ++ +  g+ +r  ++ gk      +++ pNG+++s+ ++ l+++D  +++++ ++ + ++      ++ +  +++  +p Gl+vD+ +Gn++v+ 
  EFC39147.1 155 KVVLVSRQ--GKFIRHIGGeGK---GPMQFHAPNGIGISNRDNFLIVTDMKNNRVQIMSKNGDDFIYMFGKKGISNSDFL-YPTGLTVDKpTGNIIVCD 247
                 ********..*****9999444...456899***********************98887766666555555556666665.7***************** PP

         SGL 202 wgggkvvrfdpdGklie 218
                  +++++++f+p G+ i+
  EFC39147.1 248 SSNNRIQVFSPRGEFIK 264
                 *************9987 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.25
         SGL   3 EGpvwdeeegaLlwvDilgqrih 25 
                  G +   ++g+L+ vD  ++ri 
  EFC39147.1 280 TGLTINIRTGELYVVDNKNNRIQ 302
                 45555566667777776666664 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.67     1e+03      52      78 ..      46      72 ..      37      78 .. 0.79
   2 ?    3.7   0.0     0.047        70      52      73 ..     133     154 ..     127     164 .. 0.88
   3 !   16.5   0.0   4.9e-06    0.0074      52      84 ..     178     210 ..     155     212 .. 0.88
   4 ?    3.6   0.0     0.051        76      50      80 ..     225     255 ..     213     259 .. 0.81
   5 ?    3.1   0.0     0.072   1.1e+02      53      82 ..     276     305 .]     274     305 .] 0.91

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.67
  Arylesterase 52 glssanGInidadkkyiyvadilresi 78
                   ++ +  ++i+ +++ i+v+d  ++ i
    EFC39147.1 46 NFNNPIDVKISFEHHTIFVSDNGNQRI 72
                  6777888999999******99877776 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.047
  Arylesterase  52 glssanGInidadkkyiyvadi 73 
                    ls + GI +d  +  i+v+d+
    EFC39147.1 133 LLSKPQGIAVDDTNGNIFVSDS 154
                   5789***************996 PP

  == domain 3  score: 16.5 bits;  conditional E-value: 4.9e-06
  Arylesterase  52 glssanGInidadkkyiyvadilresihvmkkh 84 
                   +++++nGI+i+  + ++ v+d+ ++ + +m k+
    EFC39147.1 178 QFHAPNGIGISNRDNFLIVTDMKNNRVQIMSKN 210
                   699***************************986 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.051
  Arylesterase  50 asglssanGInidadkkyiyvadilresihv 80 
                    s +  ++G+++d     i v d+ ++ i v
    EFC39147.1 225 NSDFLYPTGLTVDKPTGNIIVCDSSNNRIQV 255
                   578999*****************99999976 PP

  == domain 5  score: 3.1 bits;  conditional E-value: 0.072
  Arylesterase  53 lssanGInidadkkyiyvadilresihvmk 82 
                   l  ++G++i+     +yv d  ++ i ++k
    EFC39147.1 276 LVNPTGLTINIRTGELYVVDNKNNRIQIYK 305
                   5679********************999987 PP

>> DUF4934  Domain of unknown function (DUF4934)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       1.6   2.3e+03      32      45 ..     100     113 ..      87     119 .. 0.75
   2 !    9.3   0.1   0.00068         1      37      98 ..     150     211 ..     128     214 .. 0.65
   3 !   13.7   0.0     3e-05     0.044      36      94 ..     244     304 ..     233     305 .] 0.76

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.6
     DUF4934  32 lkdkivvsskkqCl 45 
                  +d ++v+ +++C+
  EFC39147.1 100 KDDSLIVTCENSCV 113
                 57778888888885 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00068
     DUF4934  37 vvsskkqCllfdketGkflasvGhiGedPegysevagw.lndatgllyfs.rkpdklvkydakG 98 
                 +vs   + +++  ++Gkf++++G  G+ P  +   +g+ + +++++l  +  k++++++  ++G
  EFC39147.1 150 FVSD--SKVVLVSRQGKFIRHIGGEGKGPMQFHAPNGIgISNRDNFLIVTdMKNNRVQIMSKNG 211
                 3333..333444578**************99998865424555555554404555566665555 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 3e-05
     DUF4934  36 ivvss.kkqCllfdketGkflasvGhiGedPegysev.agwlndatgllyfsrk.pdklvky 94 
                 iv  s +++ ++f+   G f++s G +G+ P    +    ++n +tg ly   + ++++++y
  EFC39147.1 244 IVCDSsNNRIQVFS-PRGEFIKSFGSKGNGPLELVNPtGLTINIRTGELYVVDNkNNRIQIY 304
                 44444478888887.57**************77766527799********986515667777 PP

>> TolB_like  TolB-like 6-blade propeller-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.1   1.7e+03      82     273 ..      65      77 ..      48     124 .. 0.59
   2 ?    3.7   0.0      0.02        30      49      98 ..     162     213 ..     138     221 .. 0.78
   3 !    8.7   0.0   0.00062      0.92      24      90 ..     187     254 ..     178     259 .. 0.85
   4 !   14.5   0.0     1e-05     0.015      27      91 ..     239     303 ..     228     305 .] 0.79

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.1
   TolB_like  82 ldkskltaakiifnkkdlsiqrqeelidldksilrildltdstFivsdysgdsrfllvdrdgkllkkakeiptlneekekiartalaqawrsfidYnpq 180
                  d+ + +                                                                                            
  EFC39147.1  65 SDNGNQR-------------------------------------------------------------------------------------------- 71 
                 3322222............................................................................................ PP

   TolB_like 181 nkvLalatqLGevLeiydlkkdtltvrlilGpeepefnsskeggyaiipegimGysdvqvtdkaiYalfsGksfkmaeeqkeelgkeiyVFdl 273
                                                                                                        i+ Fdl
  EFC39147.1  72 ---------------------------------------------------------------------------------------IQAFDL 77 
                 .......................................................................................222222 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.02
   TolB_like  49 elqfvssfakrGrgpeemlsaeefriskdslwvl..dkskltaakiifnkkd 98 
                 + +f++ ++ +G+gp  +  ++ + is+   + +  d  + +++ + +n +d
  EFC39147.1 162 QGKFIRHIGGEGKGPMQFHAPNGIGISNRDNFLIvtDMKNNRVQIMSKNGDD 213
                 56899999****************9998877764336555555555555555 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00062
   TolB_like  24 ikvkddilvilDlhgddffyaysypelqfvssfakrGrgpeemlsaeefrisk..dslwvldkskltaa 90 
                 i  +d+ l++ D+++++ +   s     f+  f+k+G +  ++l +  + ++k   ++ v+d+s+ +++
  EFC39147.1 187 ISNRDNFLIVTDMKNNR-VQIMSKNGDDFIYMFGKKGISNSDFLYPTGLTVDKptGNIIVCDSSNNRIQ 254
                 678999**********9.999***************************999983346777888765554 PP

  == domain 4  score: 14.5 bits;  conditional E-value: 1e-05
   TolB_like  27 kddilvilDlhgddffyaysypelqfvssfakrGrgpeemlsaeef..riskdslwvldkskltaak 91 
                   + +++ D ++++ + ++s p  +f++sf+ +G+gp e +++  +   i   +l+v+d+ + +++ 
  EFC39147.1 239 PTGNIIVCDSSNNR-IQVFS-PRGEFIKSFGSKGNGPLELVNPTGLtiNIRTGELYVVDNKNNRIQI 303
                 44588999999998.88998.999******************987633778999****977666654 PP

>> m04gp34like  Immune evasion protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.6   0.0    0.0068        10     131     156 ..     131     156 ..     113     164 .. 0.81
   2 !    6.3   0.0    0.0042       6.3     136     156 ..     230     250 ..     210     258 .. 0.80
   3 ?    3.4   0.0     0.032        48     136     156 ..     278     298 ..     262     303 .. 0.87

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0068
                  ---B-GGGTEEE---ST-EEE-TTS- CS
  m04gp34like 131 kkivtaknGfkVDkstGnLyvysnat 156
                  k+++   +G  VD+ +Gn+ v++++ 
   EFC39147.1 131 KELLSKPQGIAVDDTNGNIFVSDSKV 156
                  6778889***************9876 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0042
                  GGGTEEE---ST-EEE-TTS- CS
  m04gp34like 136 aknGfkVDkstGnLyvysnat 156
                    +G+ VDk tGn++v ++ +
   EFC39147.1 230 YPTGLTVDKPTGNIIVCDSSN 250
                  569*************98866 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.032
                  GGGTEEE---ST-EEE-TTS- CS
  m04gp34like 136 aknGfkVDkstGnLyvysnat 156
                  + +G+ ++  tG+Lyv +n++
   EFC39147.1 278 NPTGLTINIRTGELYVVDNKN 298
                  789***************987 PP

>> He_PIG  Putative Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.27   4.1e+02      22      44 ..      32      53 ..      29      56 .. 0.84
   2 ?   -0.7   0.0       1.1   1.7e+03      13      28 ..     137     152 ..     135     165 .. 0.81
   3 ?    4.4   0.0     0.028        42      12      26 ..     230     244 ..     224     255 .. 0.87
   4 !    6.4   0.0     0.007        10      13      28 ..     279     294 ..     278     301 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.27
      He_PIG 22 tGtitGtpdqtvapGsytftVta 44
                tGti G p +  +pG ++ ++++
  EFC39147.1 32 TGTIGGLPVSD-QPGNFNNPIDV 53
                99999999999.99*99977765 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.1
      He_PIG  13 PsGLtLdsstGtitGt 28 
                 P G+  d ++G i ++
  EFC39147.1 137 PQGIAVDDTNGNIFVS 152
                 899999*****99887 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.028
      He_PIG  12 LPsGLtLdsstGtit 26 
                  P+GLt d  tG i 
  EFC39147.1 230 YPTGLTVDKPTGNII 244
                 5******99999885 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.007
      He_PIG  13 PsGLtLdsstGtitGt 28 
                 P+GLt++  tG ++++
  EFC39147.1 279 PTGLTINIRTGELYVV 294
                 9***********9987 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       7.5   1.1e+04       7      75 ..      99     109 ..      95     117 .. 0.48
   2 ?   -0.2   0.0      0.76   1.1e+03       3      18 ..     140     155 ..     134     167 .. 0.76
   3 !    8.5   0.0    0.0014       2.1      56      82 ..     179     205 ..     177     210 .. 0.90
   4 ?    2.8   0.0     0.086   1.3e+02       3      19 ..     234     250 ..     226     265 .. 0.74
   5 ?   -1.1   0.0       1.4   2.1e+03       3      17 ..     282     296 ..     280     301 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 7.5
   Str_synth   7 eetgvlyftdsSskydrrqvllallegdktGrllkydkstkvvkvlldkLyfanGialsedgsfvlvce 75 
                 ++++ l++                                                           ce
  EFC39147.1  99 HKDDSLIV----------------------------------------------------------TCE 109
                 44444444..........................................................444 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.76
   Str_synth   3 ldvdeetgvlyftdsS 18 
                 + vd+++g ++++ds 
  EFC39147.1 140 IAVDDTNGNIFVSDSK 155
                 5688888888888875 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0014
   Str_synth  56 LyfanGialsedgsfvlvcetamkris 82 
                  + +nGi +s+ ++f++v+++  +r++
  EFC39147.1 179 FHAPNGIGISNRDNFLIVTDMKNNRVQ 205
                 5789*****************999975 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.086
   Str_synth   3 ldvdeetgvlyftdsSs 19 
                 l+vd+ tg +++ dsS+
  EFC39147.1 234 LTVDKPTGNIIVCDSSN 250
                 67777777777777775 PP

  == domain 5  score: -1.1 bits;  conditional E-value: 1.4
   Str_synth   3 ldvdeetgvlyftds 17 
                 l+++ +tg+ly+ d 
  EFC39147.1 282 LTINIRTGELYVVDN 296
                 899999*****9885 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0    0.0011       1.7      14      28 ..     136     151 ..     134     152 .. 0.83
   2 ?    2.8   0.1      0.08   1.2e+02      13      22 ..     229     238 ..     216     251 .. 0.81
   3 ?   -2.5   0.0       3.5   5.2e+03       8      20 ..     272     284 ..     263     293 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0011
        SBBP  14 ygngIavD.snGNiYv 28 
                 +++gIavD +nGNi+v
  EFC39147.1 136 KPQGIAVDdTNGNIFV 151
                 58999996489****9 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.08
        SBBP  13 tygngIavDs 22 
                 +y++g++vD+
  EFC39147.1 229 LYPTGLTVDK 238
                 49*******6 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 3.5
        SBBP   8 gpgastygngIav 20 
                 gp   ++++g+++
  EFC39147.1 272 GPLELVNPTGLTI 284
                 5666778888886 PP

>> Phytase-like  Esterase-like activity of phytase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.34     5e+02      79     108 ..      60      90 ..      50     107 .. 0.75
   2 ?    4.4   0.0      0.02        30      72     124 ..     139     203 ..     135     205 .. 0.87
   3 ?    5.4   0.0      0.01        15      72     105 ..     233     267 ..     201     285 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.34
  Phytase-like  79 gtfwvssEggpfilefdad.Gkllrelplpa 108
                    t++vs+ g+ +i  fd+   +++ ++ +p+
    EFC39147.1  60 HTIFVSDNGNQRIQAFDLFsQEFKYTIDTPD 90 
                   6788888888888888866455566666665 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.02
  Phytase-like  72 giav.apdgtfwvssEgg.......pfilefdadGkllrelplpaellpaaspd....aglrrnr 124
                   giav + +g+++vs+           fi+++  +Gk   ++  p+++ +++ ++    +++++nr
    EFC39147.1 139 GIAVdDTNGNIFVSDSKVvlvsrqgKFIRHIGGEGKGPMQFHAPNGIGISNRDNflivTDMKNNR 203
                   8999999999999999999999999********************99888776677777777665 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.01
  Phytase-like  72 giav.apdgtfwvssEggpfilefdadGkllrelp 105
                   g++v +p+g+++v++  +++i  f++ G++++++ 
    EFC39147.1 233 GLTVdKPTGNIIVCDSSNNRIQVFSPRGEFIKSFG 267
                   899999************************99985 PP

>> DUF839  Bacterial protein of unknown function (DUF839)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.1    0.0054         8     433     470 ..     177     212 ..     155     223 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0054
      DUF839 433 ndlespDnlafdpaGrlwiatDgsgskdellgvtaeGk 470
                  ++++p ++ ++++ + +i+tD+++++ ++  ++++G+
  EFC39147.1 177 MQFHAPNGIGISNRDNFLIVTDMKNNRVQI--MSKNGD 212
                 679**********************87664..455554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 1813.44
//
Query:       EFC39148.1  [L=607]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-15   57.2   0.6    2.2e-15   57.2   0.6    3.3  2  CDP-OH_P_transf  CDP-alcohol phosphatidyltransferase
  ------ inclusion threshold ------
       0.18   11.6   0.5       0.56    9.9   0.5    1.9  1  DUF4448          Protein of unknown function (DUF4448)


Domain annotation for each model (and alignments):
>> CDP-OH_P_transf  CDP-alcohol phosphatidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.2   0.6   2.4e-19   2.2e-15       2      66 .]     162     242 ..     161     242 .. 0.77
   2 ?   -1.4   2.7      0.48   4.3e+03      32      32 ..     440     440 ..     276     548 .. 0.65

  Alignments for each domain:
  == domain 1  score: 57.2 bits;  conditional E-value: 2.4e-19
                      -HHHHHHHHHHHHHHHHHGGGS-H..................HHHHHHHH.HHHHHTTHHHHHHHHTT---HHHHHHHHHHH CS
  CDP-OH_P_transf   2 lPnaiTllrlllsvlailllltyyp................lvlaillll.iasltDalDGklARrlnqvstlGkllDslaD 66 
                      +PnaiTl++++++ l +  + ++++                ++l i ll+  + ++D++DGk+ARr++++s lG+++D+++D
       EFC39148.1 162 APNAITLSGFFCVALVFT-ISVINYysyvitsvtsqafynfTLLLISLLIfCYNTLDGCDGKQARRTGSSSPLGEIFDHGVD 242
                      8**********9766653.333333578*********9998444444444355666*************788********99 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.48
                      H CS
  CDP-OH_P_transf  32 l 32 
                       
       EFC39148.1 440 S 440
                      1 PP

>> DUF4448  Protein of unknown function (DUF4448)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.5   6.3e-05      0.56     144     178 ..     481     515 ..     355     520 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 6.3e-05
     DUF4448 144 ledkeseegkkaekyalaialPvvvvvlvlgligf 178
                 + + ++++ ++++k++l+i+lP++v++l  + ++f
  EFC39148.1 481 IARVSNQPYPRYTKQYLVIVLPMIVFILNGLTVIF 515
                 566789999****************9998777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (607 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       975  (0.0543812); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.25s 00:00:00.93 Elapsed: 00:00:00.45
# Mc/sec: 4020.92
//
Query:       EFC39149.1  [L=268]
Description: Hypothetical protein NAEGRDRAFT_73109 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00014   22.0   0.7    0.00042   20.5   0.7    1.9  1  DUF4240     Protein of unknown function (DUF4240)
    0.00049   19.9   0.0      0.001   18.9   0.0    1.5  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.067   13.1   0.0       0.14   12.1   0.0    1.5  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> DUF4240  Protein of unknown function (DUF4240)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.7   7.1e-08   0.00042      68     118 ..     189     252 ..     135     262 .. 0.83

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 7.1e-08
     DUF4240  68 ggcsddgFlyfrawliaqGrevyeevladpdsLaelpave.............deeeelefeel 118
                 + ++ddg +y+ + +i++G+e+y+++ adp+s ae + +e             +++ e e+ee+
  EFC39149.1 189 DDFEDDGGMYAVCKIISEGEEYYNKICADPESGAESEGYEnymypfnrttyipEDYSESELEEV 252
                 5789*******************************99999666666666666666666666665 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   1.7e-07     0.001       5      35 ..      56      86 ..      55      92 .. 0.94

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 1.7e-07
  F-box-like  5 PdEiLlqIFsyLppsdLlrlalVCrrWrrva 35
                P EiL+ I++y + + L ++ lV+++++++ 
  EFC39149.1 56 PQEILSLILDYANVEALQNIKLVSKSFYDLS 86
                99**************************986 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   2.3e-05      0.14       7      45 ..      56      94 ..      54      96 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 2.3e-05
                -HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHH CS
       F-box  7 PsevlrhILerLplsdllalrrVSkgwrilidsdrlwck 45
                P e+l  IL + +   l ++ +VSk++++l  +d+++ k
  EFC39149.1 56 PQEILSLILDYANVEALQNIKLVSKSFYDLSVMDKRYEK 94
                89****************************999998865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (268 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       875  (0.0488036); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1635.06
//
Query:       EFC39150.1  [L=495]
Description: hypothetical protein NAEGRDRAFT_81411 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.6e-60  202.7   7.5    5.8e-38  131.1   2.2    2.2  2  Trp_dioxygenase  Tryptophan 2,3-dioxygenase
  ------ inclusion threshold ------
       0.12   12.3   0.0        0.4   10.6   0.0    1.8  2  Gp_UL130         HCMV glycoprotein pUL130


Domain annotation for each model (and alignments):
>> Trp_dioxygenase  Tryptophan 2,3-dioxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.1   2.2   6.5e-42   5.8e-38      12     235 ..      73     311 ..      65     340 .. 0.77
   2 !   74.6   0.3     1e-24     9e-21     265     345 ..     392     470 ..     367     471 .. 0.90

  Alignments for each domain:
  == domain 1  score: 131.1 bits;  conditional E-value: 6.5e-42
  Trp_dioxygenase  12 ksGllYgdYlkldkllsaqrllseadgkkvhdEhlFivihqayElWfkqivfeldsvrrlls..........eeivd..eertlkilkrlkRvv 93 
                      k  ++Y++Y++ d+ll++q+   + +g + hdEhlFiv+hq  ElWfkqi+feldsv+ +l+          +e vd  +e+t  +++rl+R  
       EFC39150.1  73 KVIVTYNNYIMTDELLKLQNGDCK-GGLNHHDEHLFIVVHQSFELWFKQILFELDSVQTVLRkvvnyatshsNEDVDltVEQTQILVHRLNRAD 165
                      55579****************999.9999****************************9999733322211112333311233455789****** PP

  Trp_dioxygenase  94 rilelLvaqvtvLetltpldfldfReylspasGFqslqfRllEnklGvksesrvkynrk.ykevfedddl..elllvteeekslldlveawler 184
                      +il+     +++Let+ p+dfl++R+ ++pasGFqs q R lE  lG ++ +r    r+ ++e +++d    ++l++ + e s  +lv +wle 
       EFC39150.1 166 QILRYTLGTFDILETMHPADFLEYRSVIGPASGFQSIQMRELEVMLGLRDCNRNMGSRNsFEEDLQHDLIgmKRLKQRQSEMSVRKLVYRWLEE 259
                      **************************************************98766666666666666654679999999999***********9 PP

  Trp_dioxygenase 185 tPGlesdgfnfwgkfeksvekllaellakaaaek.deevlerdltaeyekak 235
                          +  + +f   f +  +++l+ +  +  +++ + + +++++ +e++ ak
       EFC39150.1 260 VVYPKIPANQFIQIFLERKKDHLMFQKCRWFNPEtEMQTIQEQIEREMKPAK 311
                      7655777888888888777777776666655544044566666655554443 PP

  == domain 2  score: 74.6 bits;  conditional E-value: 1e-24
  Trp_dioxygenase 265 GalmiyvYrdeprfselyqlleaLmDidelltkWRynHvvlvqRmlGskaGtGGssGyayLrstvsdrykvFldLfnlsty 345
                        l+i+ Yr ++  ++ ++ll +L+ ++e l  WR  Hv +v+Rm+G++ GtGGssG+ yL++  + +y+vFldL++ +++
       EFC39150.1 392 ALLFIMSYRHHHMLWDYANLLDKLVALEEALLMWRTRHVRMVERMIGTRVGTGGSSGVDYLEQ--TLKYRVFLDLWESRSH 470
                      3467999********************************************************..66899*******9985 PP

>> Gp_UL130  HCMV glycoprotein pUL130
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       1.3   1.1e+04      59      82 ..      34      57 ..      32      72 .. 0.72
   2 ?   10.6   0.0   4.5e-05       0.4      49     107 ..     115     171 ..     100     178 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 1.3
                HHHHT-HHHHHHHHHHHSSS---- CS
    Gp_UL130 59 lsgrnqtilqrmprtaskpsdgnv 82
                ls  n  i q   +++s  sd  +
  EFC39150.1 34 LSSNNSQIGQERSKSSSSSSDHSI 57
                667777777777777777776543 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 4.5e-05
                 -HHHHHHHHHHHHHT-HHHHHHHHHHHSSS-------HHHHHHHHHHS-SEEEEEEEEE CS
    Gp_UL130  49 stwvkkviwylsgrnqtilqrmprtaskpsdgnvqisvedakifgahmvpkqtkllrfv 107
                   w k++++ l    qt+l+++   a+  s+ +v+++ve+++i+  h + +  ++lr+ 
  EFC39150.1 115 ELWFKQILFELD-SVQTVLRKVVNYATSHSNEDVDLTVEQTQIL-VHRLNRADQILRYT 171
                 469999998886.579**************************98.57788888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (495 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1061  (0.0591779); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.23s 00:00:00.78 Elapsed: 00:00:00.40
# Mc/sec: 3750.88
//
Query:       EFC39151.1  [L=440]
Description: serine/threonine protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.4e-64  215.3   0.2    1.2e-63  214.9   0.2    1.1  1  Pkinase         Protein kinase domain
    5.7e-38  130.7   0.0    8.4e-38  130.1   0.0    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    3.2e-05   22.9   0.0    4.9e-05   22.3   0.0    1.2  1  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
      0.048   13.0   0.0      0.081   12.3   0.0    1.2  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
      0.067   13.1   0.0      0.099   12.6   0.0    1.2  1  APH             Phosphotransferase enzyme family
       0.44   10.9   4.0        2.2    8.7   0.4    2.5  2  RICH            RICH domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  214.9   0.2   4.1e-67   1.2e-63       5     264 .]     130     411 ..     127     411 .. 0.90

  Alignments for each domain:
  == domain 1  score: 214.9 bits;  conditional E-value: 4.1e-67
                 EEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.......HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS-- CS
     Pkinase   5 eklGeGsfGkVykaveketgkivAvKkikkekakkkke.......kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgsls 96 
                  +lG+GsfG+V+ a++k+tg+++A+K+i+++k ++          k +++E k + +++hpn++++y+++ ++  +y++l+y+++g+l+d+ +     +
  EFC39151.1 130 GTLGSGSFGTVVLAKHKQTGQKFALKTIREKKGENPFGddesdqnKLIWAEFKAIYESDHPNLLKVYNCYFKDLCFYMLLDYCNCGSLKDVFKVTEGTT 228
                 68**************************9998654333344555699**********************************************9999** PP

                 HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTE.....EEE-SGTTSEESSSSCS......BCTTTSCGGGS-HHHHTTSCBSHHHHHHHH CS
     Pkinase  97 eeeakkiakqilegleylH.skgiiHrDlKpeNiLidekge.....lKitDFGlakelesssk......ltsfvgtseYlAPEvlkeneyskkvDvWsl 183
                 e+ ++ i+++il+gl+yl  +k+i+HrD+KpeNiL+d +++     +Ki+DFGl+ + ++s+k      ++++ gt+ Yl+PE l++ +y  ++D+Wsl
  EFC39151.1 229 ERMMSVIVEKILKGLQYLQkEKHIVHRDIKPENILVDYDQNtqkaeVKIGDFGLCGHKKESNKdigktmFSTVNGTKIYLSPERLQGYSYNYNSDIWSL 327
                 *******************5556**************655557899*************99999*********************************** PP

                 HHHHHHHHHSS-STTTSSHHHHHHHHHHT....HHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 184 Gvilyelltgkppfsgekgkekvekeldq....lekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264
                 Gv+ +el+tg +p+s  ++ + +  ++d+      ++l+il++++ +l+ ++++s e+kd++ k+++ ++ kR+ aeell hp++
  EFC39151.1 328 GVLTIELMTGVHPLSTLTTLS-HFDIVDKleniQNELLQILNNYDATLKPEKKLSAEFKDFILKCCEPTKDKRPFAEELLTHPWI 411
                 ***************655554.666677722333455678889*****************************************7 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  130.1   0.0   2.8e-41   8.4e-38       6     256 ..     131     406 ..     127     408 .. 0.81

  Alignments for each domain:
  == domain 1  score: 130.1 bits;  conditional E-value: 2.8e-41
                  EEEEESSEEEEEEEEETTTTSSEEEEEEEEEST........TSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   6 klGeGafGkVvegtlkgekekkevkVavKtlke........eateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk 95 
                  +lG+G+fG+Vv ++ k    ++ +k a+Kt++e        + ++++++ +  e k + + +hpn++k++ ++ k+   +++++y++ G+L++  + +
   EFC39151.1 131 TLGSGSFGTVVLAKHK----QTGQKFALKTIREkkgenpfgDDESDQNKLIWAEFKAIYESDHPNLLKVYNCYFKDLCFYMLLDYCNCGSLKDVFKVT 224
                  79************99....99999******8733444442233444666778*******************************************98 PP

                  CTTTSBHHHHHHHHHHHHHHHHHHHH.TTEEEST-SGGGEEEEE.....TTEEEE-STTTHEETTTSSEE...EETTSSTSGGGGS-HHHHHHSEEEH CS
  Pkinase_Tyr  96 ekekltlkdllsfalqvAkGmeyLes.kklvHrdlaarNvLlse.....nkvvkisDfGLardiekddey...vkkeeaklpvkWmapEslkekkfts 184
                    e +t + +  ++ ++ kG++yL++ k++vHrd+   N+L++      +  vki+DfGL+ + +++++    ++ ++ +    +++pE l+  +++ 
   EFC39151.1 225 --EGTTERMMSVIVEKILKGLQYLQKeKHIVHRDIKPENILVDYdqntqKAEVKIGDFGLCGHKKESNKDigkTMFSTVNGTKIYLSPERLQGYSYNY 320
                  ..66666666777889********862679************9655665789*********9985444443323333444556799************ PP

                  HHHHHHHHHHHHHHHTTSSGT...............TTTSHHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 185 ksDvWsfGvllwEiftlgesp...............ypglkneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRptfselv 256
                  +sD+Ws Gvl++E++t g +p               ++++ ++e+l+ l + +  l+  +k ++e+++++ kc e ++++Rp  +el+
   EFC39151.1 321 NSDIWSLGVLTIELMT-GVHPlstlttlshfdivdkLENI-QNELLQILnNYDATLKPEKKLSAEFKDFILKCCEPTKDKRPFAEELL 406
                  ****************.99998999999998886644444.445677773556667888899********************998886 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.0   1.6e-08   4.9e-05     305     398 ..     228     325 ..     222     328 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 1.6e-08
  Pkinase_fungal 305 pkellealrD.aIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesga...rertGTleFmaievlkgeeHsyrh 395
                      +++++++ +  +kg++ L +++ i+HrDi  +Nil+  ++++++ +  + D+ l  + ++ +++ g+    +  GT+ +++ e l+g + +y  
      EFC39151.1 228 TERMMSVIVEkILKGLQYLQKEKHIVHRDIKPENILVDYDQNTQKAEVKIGDFGLCGHKKESNKDIGKtmfSTVNGTKIYLSPERLQGYSYNYNS 322
                     55667766541569**********************99889999999*********9999877766667778999************99899998 PP

  Pkinase_fungal 396 DLE 398
                     D+ 
      EFC39151.1 323 DIW 325
                     875 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   2.7e-05     0.081     104     179 ..     216     293 ..     211     301 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.7e-05
         Kdo 104 dLedllakwaelaeelkrallkavgrliaklhr.agvnHadlyaknillqqee.eeeaeiwliDldkarlrlradrwr 179
                 +L+d+ +  +   e++   +++++ +  + l +  ++ H+d+ + nil++ ++  ++ae+ + D+  + ++   +++ 
  EFC39151.1 216 SLKDVFKVTEGTTERMMSVIVEKILKGLQYLQKeKHIVHRDIKPENILVDYDQnTQKAEVKIGDFGLCGHKKESNKDI 293
                 5555555433366677777777777777777541689*************99988999**********9999877765 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   3.3e-05     0.099     163     184 ..     247     269 ..     208     285 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.3e-05
                 SS-EEEE-SS-SGGGEEEC...T CS
         APH 163 elptvllHgDlhpgNllvd.pdd 184
                 + ++ ++H+D++p N+lvd +++
  EFC39151.1 247 QKEKHIVHRDIKPENILVDyDQN 269
                 57899**************6444 PP

>> RICH  RICH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.2     0.053   1.6e+02      15      32 ..     236     252 ..     228     259 .. 0.87
   2 ?    8.7   0.4   0.00072       2.2      35      63 ..     350     378 ..     345     388 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.053
        RICH  15 lekiLseikkqldKrkht 32 
                 +ekiL+++ + l+K+kh+
  EFC39151.1 236 VEKILKGL-QYLQKEKHI 252
                 69******.99******7 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00072
        RICH  35 vaLikkLseIkteyLyelkvlkekskael 63 
                 ++++ kL++I++e L+ l++  ++ k e 
  EFC39151.1 350 FDIVDKLENIQNELLQILNNYDATLKPEK 378
                 799*****************999987432 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (440 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       516  (0.0287802); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.53u 0.24s 00:00:00.77 Elapsed: 00:00:00.43
# Mc/sec: 3038.00
//
Query:       EFC39152.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00062   19.5   0.2     0.0017   18.1   0.2    1.7  1  Rad50_zn_hook  Rad50 zinc hook motif
  ------ inclusion threshold ------
        2.5    7.9   8.2       0.23   11.3   3.7    1.6  2  CCDC24         Coiled-coil domain-containing protein 24 famil


Domain annotation for each model (and alignments):
>> Rad50_zn_hook  Rad50 zinc hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.2   1.9e-07    0.0017      15      43 ..      26      53 ..      17      59 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.9e-07
                   HTT-SEE-TTT--EE-HHHHHHHHHHHHH CS
  Rad50_zn_hook 15 lkeakgcCPlCgReldeehrseLikelqs 43
                   ++++k  CPlC+R l++e+r+++++ +++
     EFC39152.1 26 IHKHK-FCPLCKRVLSQERRKKVQDIYRK 53
                   55556.8***************9887765 PP

>> CCDC24  Coiled-coil domain-containing protein 24 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   3.7   2.6e-05      0.23      53     163 ..      33     151 ..       7     155 .. 0.65
   2 ?   -3.2   0.1      0.73   6.5e+03     128     130 ..     241     243 ..     221     258 .. 0.38

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 2.6e-05
      CCDC24  53 PllRdlleqeirlLlqsLqekaaaegrdeeqllaqrsrrvldYvl.......daaaersareespssrPesasskstaasaasgsssasal........ 136
                 Pl + +l qe r  +q + +k+     + ++++ +r ++v +Y          + +++ ++e+ +  rP+++ss+s   s++s+sss+s++        
  EFC39152.1  33 PLCKRVLSQERRKKVQDIYRKH----HSLNDAMFRRGKSVTRYSSsarslpsVDITSHMGEESLSFYRPSTSSSSS---SSSSSSSSSSSNttitlekq 124
                 5566677777777777775555....55566666788999999998888855444455566666777999999988...22222222222223344444 PP

      CCDC24 137 ssasaelealkdkLNvsdiDeVaehLr 163
                 s+  + ++ ++++ N +++   +++Lr
  EFC39152.1 125 SKIYSSMKDMSSSGNLEQFSPLTRKLR 151
                 666666666666666666666666666 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.73
      CCDC24 128 sgs 130
                  ++
  EFC39152.1 241 DQK 243
                 111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1936  (0.107981); expected 358.6 (0.02)
Passed bias filter:                      668  (0.0372581); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 1630.71
//
Query:       EFC39153.1  [L=664]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.6e-17   63.1   0.2    3.7e-17   62.6   0.2    1.3  1  LCAT          Lecithin:cholesterol acyltransferase
    2.2e-08   34.1   0.1    1.9e-06   27.8   0.0    2.5  3  PGAP1         PGAP1-like protein
     0.0022   17.5   0.0     0.0037   16.8   0.0    1.2  1  DUF900        Alpha/beta hydrolase of unknown function (DUF90
     0.0036   16.8   0.9     0.0073   15.8   0.3    1.8  2  Lipase_2      Lipase (class 2)
  ------ inclusion threshold ------
      0.085   12.3   0.1       0.16   11.5   0.1    1.3  1  DUF676        Putative serine esterase (DUF676)
       0.21   11.9   0.2       0.21   11.9   0.2    2.2  2  Nodulin_late  Late nodulin protein


Domain annotation for each model (and alignments):
>> LCAT  Lecithin:cholesterol acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.6   0.2   1.3e-20   3.7e-17      47     192 ..     126     269 ..     109     373 .. 0.85

  Alignments for each domain:
  == domain 1  score: 62.6 bits;  conditional E-value: 1.3e-20
        LCAT  47 dqGfeaieyldkskia..gkqyeiwkklvknlvkiGyeknktvvaapYDWRlsleerdkYfskLkelieealk.lsgkkvvliaHSmGnllvlyflkwv 142
                  +G++a++ l++   +  g++   +++l++ l +iGye++ t++a pYDWR s   +  +  kL + i ++   ++++kv li+HSmG+ ++      +
  EFC39153.1 126 RSGLYAVDNLNPDSDNgvGPKRYYFHELIEYLKSIGYEEGVTLFAFPYDWRDSII-NSAF--KLSTYIANIKTlTKANKVNLISHSMGGYVSKTAYVVN 221
                 479*******77655555555558****************************975.4568..9******99998999************9976544443 PP

        LCAT 143 eaeaWvdqhikafislgapllGsvk.avkallsGenkgipvlseltlrvls 192
                 ++     + ++  is ++p+ G  +  +++ l G n + + l+ l++r +s
  EFC39153.1 222 RELY---KSVNVHISFATPWQGTGRdWIASSLFGGNLNNIKLDALAVRDVS 269
                 3333...689999*********98735788899999999999999988766 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.017        50       6      27 ..      57      78 ..      54     127 .. 0.84
   2 !   27.8   0.0   6.4e-10   1.9e-06      85     134 ..     194     243 ..     147     278 .. 0.85
   3 ?   -3.2   0.0       1.9   5.7e+03     161     189 ..     531     559 ..     510     568 .. 0.72

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.017
       PGAP1  6 pVlFvpGnagsykqvrslAsea 27
                p++++pG a s+  v  +A+  
  EFC39153.1 57 PIILIPGYAASMLSVEEIANPG 78
                9****************99765 PP

  == domain 2  score: 27.8 bits;  conditional E-value: 6.4e-10
       PGAP1  85 ssekeptsviliGHSmGGivaraaltlknyikqsvntiltlasPhalppl 134
                 ++ ++ ++v li HSmGG v+++a + ++   +svn  ++ a+P + +  
  EFC39153.1 194 KTLTKANKVNLISHSMGGYVSKTAYVVNRELYKSVNVHISFATPWQGTGR 243
                 34568899************************************987655 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 1.9
       PGAP1 161 lenvllvsitggirdsmvpaeyssleelv 189
                   n ll s+tg+i d   +  y+   ++ 
  EFC39153.1 531 DGNCLLSSMTGSILDLSSNTMYTLTGQRS 559
                 45788999999999999888888766555 PP

>> DUF900  Alpha/beta hydrolase of unknown function (DUF900)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   1.2e-06    0.0037      63     108 ..     168     214 ..     164     226 .. 0.88

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.2e-06
      DUF900  63 lldynyD.resaeasrdalekllrylatkksakkihllaHSmGtwlv 108
                 l+++ yD r+s+  s+ +l + +  ++t ++a+k++l+ HSmG ++ 
  EFC39153.1 168 LFAFPYDwRDSIINSAFKLSTYIANIKTLTKANKVNLISHSMGGYVS 214
                 56677775779999*****************************9985 PP

>> Lipase_2  Lipase (class 2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.3   2.4e-06    0.0073      18      91 ..     150     216 ..     141     231 .. 0.86
   2 ?   -4.0   0.0       2.9   8.6e+03       3      29 ..     294     319 ..     293     323 .. 0.65

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 2.4e-06
    Lipase_2  18 lskliqkflekgytea.elYattygdteestslerlekCeyvkqlRklilaVlkyTgakkvdivahsmGvpiaRk 91 
                 +++li+++++ gy+e  +l+a+ y+ + +  ++++++      +l + i  ++  T+a+kv+ ++hsmG+ +++ 
  EFC39153.1 150 FHELIEYLKSIGYEEGvTLFAFPYDWRDS--IINSAF------KLSTYIANIKTLTKANKVNLISHSMGGYVSKT 216
                 6789999999**9986589**99997776..888888......88999999******************998875 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 2.9
    Lipase_2   3 PviivhGnsdlaaeklskliqkflekg 29 
                 P i+++G+s     ++ + ++ fl+++
  EFC39153.1 294 PRIVINGVSV-TEDQVIQGLKSFLKEN 319
                 7799999965.5556666666666655 PP

>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.1   5.2e-05      0.16      72     129 ..     194     241 ..     182     252 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5.2e-05
      DUF676  72 kkkkdknkkiSfvghSlGgliaraaiaklkekemtlkeaikglepvtfitlasPhLGv 129
                 k   +  +k+ ++ hS+Gg +++ a  +   +e  +k       +   i++a+P+ G+
  EFC39153.1 194 KTLTKA-NKVNLISHSMGGYVSKTAYVVN--RE-LYK------SVNVHISFATPWQGT 241
                 333444.59*************9997733..33.346......56778*******986 PP

>> Nodulin_late  Late nodulin protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.6       4.5   1.4e+04       4      17 ..      14      27 ..       8      28 .. 0.70
   2 ?   11.9   0.2   7.1e-05      0.21      26      52 ..     561     586 ..     548     586 .. 0.83

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.5
  Nodulin_late  4 ilkfvYalilflsl 17
                  i+ + +++ lf sl
    EFC39153.1 14 IVVLLFMMNLFSSL 27
                  45566777777776 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 7.1e-05
  Nodulin_late  26 akieCktdadCpkkcpkpykvkCingi 52 
                    + eC++d+ Cp+    + + kCi+g+
    EFC39153.1 561 SGNECNSDKSCPTE-NGNSVRKCIDGF 586
                   578***********.7779*****985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (664 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       872  (0.0486363); expected 358.6 (0.02)
Passed bias filter:                      585  (0.0326287); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.83u 0.39s 00:00:01.22 Elapsed: 00:00:00.60
# Mc/sec: 3358.39
//
Query:       EFC39154.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.055   13.7   0.1        0.3   11.3   0.0    2.2  2  BEN          BEN domain
        0.2   12.0   0.9        2.5    8.5   0.6    2.7  2  AAA_assoc_2  AAA C-terminal domain


Domain annotation for each model (and alignments):
>> BEN  BEN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.26   2.3e+03      48      65 ..      63      80 ..      36      91 .. 0.65
   2 ?   11.3   0.0   3.4e-05       0.3      31      71 ..     141     184 ..     126     186 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.26
                HHHHHH--.......... CS
         BEN 48 yveerypsekededwwre 65
                ++ee y ++++de ++++
  EFC39154.1 63 VTEEIYKTKSDDEAQQKI 80
                567777775555555544 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 3.4e-05
                 T....---EE--HHHHHHHHHHHHHHH--..........-HHHHH CS
         BEN  31 r....ppkkaLDpnklsaIrnyveerypsekededwwrecldqIn 71 
                 +    + k++L+p + + + + v  +++ e++ e w+  ++d+In
  EFC39154.1 141 StvnvDEKNPLNPQIAQQMFEMVSRHCDKERSLEEWI-AGDDRIN 184
                 3445689**********************55555555.5999998 PP

>> AAA_assoc_2  AAA C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.15   1.4e+03      53      74 ..      51      72 ..      38      72 .. 0.78
   2 ?    8.5   0.6   0.00028       2.5       4      41 ..      69     129 ..      65     220 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.15
                 XXXXXXXXXXXXXXXXHHHHHH CS
  AAA_assoc_2 53 ealqrkalryDkagdehYdliS 74
                 ++l+   ++ Dk  +e Y + S
   EFC39154.1 51 DVLDLDLVQLDKVTEEIYKTKS 72
                 5667778999999999998866 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00028
                  .XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX........................X CS
  AAA_assoc_2   4 klkleddalealaeladGDaRkaLnlLElaaeaaeak.......................e 41 
                  k k +d+a + + el dGD Rk    ++l +++++++                       +
   EFC39154.1  69 KTKSDDEAQQKISELFDGDLRKPSRNIDLFLTKNQDNigemgsridqilhmnpkqafakwN 129
                  56889*****************999999999888877777666665555555555555550 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       838  (0.0467399); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1346.14
//
Query:       EFC39155.1  [L=657]
Description: hypothetical protein NAEGRDRAFT_52651 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.49    9.3   2.8       0.28   10.1   0.6    1.6  2  LMBR1     LMBR1-like membrane protein


Domain annotation for each model (and alignments):
>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.6   1.6e-05      0.28     197     294 ..      17     127 ..      10     135 .. 0.78
   2 ?   -2.8   0.1      0.12   2.1e+03     299     323 ..     231     255 ..     185     278 .. 0.68

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 1.6e-05
       LMBR1 197 dldeelkklyfeaaklntekeeaereledllkevkklrksisesdplrkyleeilkkvPeeiaeklks..................nenkteeslakle 277
                 + +ee++++ +  + +++ +e+ +++l      vkk+++  + ++  ++ le+il+++P+ ++ +++s                  ++++t+es++k+ 
  EFC39155.1  17 KQEEEIEATATIPPIISNHEEDIHHQLI-----VKKSSNANNITNLDHDSLENILSYCPNRASYEMQSlkaccrtwnslmegsgimDNPSTKESISKSV 110
                 5566666665555566666667677777.....5555555555554569**********************************9966666999999999 PP

       LMBR1 278 kqlikalqkrertekqw 294
                 k+ i++ +  +r+e+ +
  EFC39155.1 111 KESIRSTSLLHRIEEAY 127
                 99999988888887765 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.12
       LMBR1 299 ekalelediiknksskekefksses 323
                 e+a++l  ++kn++++ek++k+  s
  EFC39155.1 231 EEAYKLFHVVKNAEDQEKKLKKHIS 255
                 3344444555555555555554433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (657 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1117  (0.0623013); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.78u 0.33s 00:00:01.11 Elapsed: 00:00:00.54
# Mc/sec: 3647.28
//
Query:       EFC39156.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       581  (0.0324056); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2020.50
//
Query:       EFC39157.1  [L=271]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-56  192.4   1.9    1.2e-56  192.2   1.9    1.0  1  Palm_thioest   Palmitoyl protein thioesterase
    4.1e-05   23.0   0.0    8.2e-05   22.0   0.0    1.5  2  Hydrolase_4    Serine aminopeptidase, S33
    0.00014   21.6   0.0    0.00021   21.0   0.0    1.3  1  Abhydrolase_1  alpha/beta hydrolase fold
    0.00083   18.8   0.3     0.0016   17.9   0.1    1.6  2  DUF915         Alpha/beta hydrolase of unknown function (DUF9
     0.0088   16.7   0.0      0.012   16.2   0.0    1.2  1  Abhydrolase_6  Alpha/beta hydrolase family


Domain annotation for each model (and alignments):
>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  192.2   1.9   3.5e-60   1.2e-56      16     242 .]       2     252 ..       1     252 [. 0.86

  Alignments for each domain:
  == domain 1  score: 192.2 bits;  conditional E-value: 3.5e-60
  Palm_thioest  16 qklaeliekli..gtyvknveigeseaedrkasffgnlndqveavckk.......lelangfhaiGfSQGglflRaliercddkknvrnlislggpq 103
                   +++++++ k +  gt +++v      + +++ s+++n+ dqve++++k        ++ +++h+i++SQGgl++R +i+ ++++  v+ +isl+g+q
    EFC39157.1   2 SDVKKYLAKYVpqGTLIYSVP-----STNTETSLLMNMMDQVEDFASKvqelqnlYNF-KNYHLICHSQGGLICRSFIQLYPNHG-VKVFISLSGVQ 91 
                   667777777666458888888.....556889************88888889886444.78********************8777.*********** PP

  Palm_thioest 104 aGvfgl..............llckvaekllasgavysklvqkslvqaqywrdpekleeYlkknkFLpdiNnerdha...knetykknllkleklvlv 183
                   +G+fg+              ++    +k+ a +++y+++ qk++++a+yw+dp +++eY+++++FL+ +Nn    +   ++ +++ n+l+++k+vl 
    EFC39157.1  92 NGQFGIpgilsweqewkknfPFLWNLTKEEAFHFFYTDFFQKTMSVAGYWKDPFHYDEYRQNSQFLAVVNNDSLIHdyaSKYQFRSNFLQIDKMVLT 188
                   *****55666777777777755566667788888********************99***************975445667778999*********** PP

  Palm_thioest 184 gfsdDtvvvPkeSslfgfykeks.eev...pleetelYkedllGLrtLdergrlellevpg.eH 242
                    ++dD+v++P  S+lfgfy+ ++ +++    + ++++Yk+d++GL+tLd+++rl +++vpg +H
    EFC39157.1 189 TSPDDEVIKPYYSALFGFYALNNqNQLaqsLMPDQQIYKNDVFGLKTLDSQKRLIVHVVPGiNH 252
                   *******************998863334669*****************************9887 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0   2.3e-08   8.2e-05      54     164 ..      33     166 ..      24     204 .. 0.67
   2 ?   -3.0   0.0      0.98   3.5e+03     224     238 ..     244     258 ..     236     259 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 2.3e-08
  Hydrolase_4  54 sfddyvdDlaafvekvkeehpelplfllGhSmGGliallyllrypd.kvaglilsaPalkikaklkappllklllkllgkllpklqv........... 139
                  ++ d v+D+a+ v+++++ ++ ++  l++hS GGli  ++++ yp+  v+ +i  + + + +    +p +l + +++ +++   + +           
   EFC39157.1  33 NMMDQVEDFASKVQELQNLYNFKNYHLICHSQGGLICRSFIQLYPNhGVKVFISLSGVQNGQFG--IPGILSWEQEWKKNFPFLWNLtkeeafhffyt 128
                  677889****************************************344466666665555544..67777776666666655555534444444444 PP

  Hydrolase_4 140 .............snnlkadslsrdpevvaayeadplv 164
                               +++   d   ++ +++a +++d+l+
   EFC39157.1 129 dffqktmsvagywKDPFHYDEYRQNSQFLAVVNNDSLI 166
                  44444444444444444444444444444444444444 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.98
  Hydrolase_4 224 lklypglyHellnEp 238
                  +++ pg  H+l+ E+
   EFC39157.1 244 VHVVPGINHMLWIES 258
                  678899999998886 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   5.9e-08   0.00021      58     140 ..      40     135 ..      19     202 .. 0.72

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 5.9e-08
                    HHHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHHH.GGGEEEEEEESE...........CSSCCHHHHHHHHHHHH.HHCHHCHHHHHHHHHHH CS
  Abhydrolase_1  58 svaddldrildalgddkltlvGhSmGGmialayaaey.perVkalvllga...........idpaaslieaqrqqaks.fpdffdgyaadcarnpa 140
                    ++a  ++ +++ ++ ++ +l+ hS+GG+i++ + ++y ++ Vk +++l++           +++  ++ +  ++ ++    ++f  ++ d++++++
     EFC39157.1  40 DFASKVQELQNLYNFKNYHLICHSQGGLICRSFIQLYpNHGVKVFISLSGvqngqfgipgiLSWEQEWKKNFPFLWNLtKEEAFHFFYTDFFQKTM 135
                    45555567799999***********************8899*********8877666555555555555555554432133444444444444444 PP

>> DUF915  Alpha/beta hydrolase of unknown function (DUF915)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.1   4.3e-07    0.0016      85     127 ..      37      79 ..      22      94 .. 0.83
   2 ?   -3.5   0.0       1.4     5e+03     119     141 ..     168     190 ..     164     198 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 4.3e-07
      DUF915  85 qakwlkkvlseLkkkYnikkfnavGhSmGglaltsYleeyadd 127
                 q + + + ++eL++ Yn+k+  ++ hS Ggl + s+++ y + 
  EFC39157.1  37 QVEDFASKVQELQNLYNFKNYHLICHSQGGLICRSFIQLYPNH 79 
                 5555566689**************************9988765 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.4
      DUF915 119 sYleeyaddkslPqlkklvtigg 141
                  Y+ +y+  +++ q++k+v   +
  EFC39157.1 168 DYASKYQFRSNFLQIDKMVLTTS 190
                 58888888888888888886555 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0   3.3e-06     0.012      54     214 ..      39     258 ..       7     264 .. 0.46

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 3.3e-06
                    HHHHCCTT.......TTSEEEEEETCHHHHHHHHHHCC..EE..EEES-..----TTTS----TTHHHHHHTT-CCCCHCCH......S-HSCCCC CS
  Abhydrolase_6  54 aalldelaa.....gggpvvlvGHSlGGalalaaaplalvvg..vlldppptalpagllaaalelllallallrllawlsre......plprlfla 136
                    ++++ ++ +     + ++ +l++HS+GG++   +  l +++g  v+++  +++ +   ++ +l++ + + +++++  w  ++      +++ +f+ 
     EFC39157.1  39 EDFASKVQElqnlyNFKNYHLICHSQGGLICRSFIQLYPNHGvkVFISLSGVQNGQFGIPGILSWEQEWKKNFPF-LWNLTKeeafhfFYT-DFFQ 132
                    3333333334446677778**********7777555557777776666622333333355555555555557776.999544333343333.3333 PP

                    HHH.CCCCHCHCCCGHHHHCCHHC...HTTCCHHTT-TTGC...........EEE..CTT-C....................HHHHCHHCCCHSTT CS
  Abhydrolase_6 137 ded.adaawrarlarlaallaglg...llpaaawadlpvpl...........lvl..ggeDp....................lvprllerllaqag 195
                    ++     +w +++      +++ +    ++ + + d+ + +           +vl    +D+                    l + l+      ++
     EFC39157.1 133 KTMsVAGYWKDPFHYDEYRQNSQFlavVNNDSLIHDYASKYqfrsnflqidkMVLttSPDDEvikpyysalfgfyalnnqnqLAQSLM------PD 222
                    3332134444444333322222221211112222222222233344444444333213444433333333333222222111111111......22 PP

                    EEET..................CE...SSS-HHHHSH CS
  Abhydrolase_6 196 arlp..................vvlpgaGHlphleep 214
                     ++                   +v+pg  H++++ e 
     EFC39157.1 223 QQIYkndvfglktldsqkrlivHVVPGINHMLWI-ES 258
                    2221233334446666777777778887787777.44 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (271 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.47u 0.28s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1830.19
//
Query:       EFC39158.1  [L=1474]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.005   16.2   4.9      0.015   14.6   0.1    2.5  2  SLAC1     Voltage-dependent anion channel
  ------ inclusion threshold ------
      0.032   14.1   0.0      0.074   12.9   0.0    1.5  1  DUF5337   Family of unknown function (DUF5337)
        6.3    6.8  11.8       0.26   11.3   1.5    3.5  3  Y_Y_Y     Y_Y_Y domain


Domain annotation for each model (and alignments):
>> SLAC1  Voltage-dependent anion channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   1.1     0.013        80      38     114 ..    1060    1149 ..    1036    1180 .. 0.49
   2 !   14.6   0.1   2.5e-06     0.015     237     266 ..    1264    1293 ..    1216    1309 .. 0.70

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.013
       SLAC1   38 lalvlfllllvlyllrfilypeavrkelrhpveslflgtfpmgl.ltilnglllvl.pg..............ewlatlalvllWigvllsll 114 
                  + l+  l+++++++++ i++++   +         f+++++ +l +++ + ++  + ++               ++  l+l++lW+g + s++
  EFC39158.1 1060 IVLLYSLFFTCVFCIQTIRKKKINIENE--KEWESFIPALFATLpMFLAIRVCRGCvKSqderkrrycsvfivGTM-LLLLAVLWLGGFGSVV 1149
                  2222222334444444444433222221..2234455555444444444333332222234455555555553344.4444448865544443 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 2.5e-06
       SLAC1  237 kvlalllalflwglglfwllvavlsvlslp 266 
                    +a  ++lfl+g++++++l+ +++++++p
  EFC39158.1 1264 LCIAATFGLFLLGFAIWFFLFLFIACIQAP 1293
                  2366668********************965 PP

>> DUF5337  Family of unknown function (DUF5337)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   1.2e-05     0.074       8      35 ..    1117    1144 ..    1114    1150 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.2e-05
     DUF5337    8 alarkgrlvalviavtmllwlgaqwige 35  
                  ++ rk r  ++ i++tmll l++ w+g+
  EFC39158.1 1117 QDERKRRYCSVFIVGTMLLLLAVLWLGG 1144
                  6789**********************96 PP

>> Y_Y_Y  Y_Y_Y domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   1.5   4.3e-05      0.26       7      34 ..      48      74 ..      45      77 .. 0.96
   2 ?   -3.9   0.5       2.4   1.4e+04      16      41 ..     303     326 ..     295     326 .. 0.55
   3 ?    0.9   0.1     0.075   4.5e+02       4      35 ..     838     867 ..     836     871 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 4.3e-05
                TEEEEEEEETTESSEEEESSTS.EEEEE CS
       Y_Y_Y  7 rllYrYrlegidkeWveasdysqeasyt 34
                +++Y+Y    ++k+W+++s ++ ++syt
  EFC39158.1 48 NNYYSYVCNDYNKSWKSTSLNG-TFSYT 74
                89********************.****9 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 2.4
                 TTESSEEEESSTS.EEEEES--SEEE CS
       Y_Y_Y  16 gidkeWveasdysqeasytnlppGdY 41 
                   d + ++++ +  +++y     G+Y
  EFC39158.1 303 RNDSNITTNTTS--TVTYATRMNGKY 326
                 344444444444..788876666666 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.075
                 CCTTEEEEEEEETTESSEEEESSTS.EEEEES CS
       Y_Y_Y   4 nperllYrYrlegidkeWveasdysqeasytn 35 
                  ++++ Y+  ++g+++  + ++++++  s+ n
  EFC39158.1 838 ISSQTNYKVNIIGYENGIIFETSSGT--SFVN 867
                 58999*******************84..4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1474 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1256  (0.0700541); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.92u 0.29s 00:00:01.21 Elapsed: 00:00:00.49
# Mc/sec: 8965.68
//
Query:       EFC39159.1  [L=844]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (844 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1266  (0.0706119); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.27s 00:00:00.97 Elapsed: 00:00:00.44
# Mc/sec: 5796.90
//
Query:       EFC39160.1  [L=846]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.2e-17   64.2  16.9    7.7e-09   35.2   0.9    4.6  4  G-alpha    G-protein alpha subunit
  ------ inclusion threshold ------
       0.13   11.6   0.7        2.1    7.7   0.0    2.8  3  TniB       Bacterial TniB protein
        1.2   10.0   7.8       0.15   12.9   1.6    2.8  2  PDZ_assoc  PDZ-associated domain of NMDA receptors


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.2   0.9   1.3e-12   7.7e-09       8     223 ..      16     334 ..      10     339 .. 0.65
   2 !    5.2   0.0    0.0016       9.8     228     245 ..     413     430 ..     395     446 .. 0.85
   3 !   27.5   0.6   2.8e-10   1.7e-06     248     294 ..     537     584 ..     516     615 .. 0.88
   4 !    4.7   0.7    0.0024        14     303     351 ..     795     842 ..     778     845 .. 0.81

  Alignments for each domain:
  == domain 1  score: 35.2 bits;  conditional E-value: 1.3e-12
                 XXXXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS--.......--HHHHHC.CHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-S CS
     G-alpha   8 dkslkaerkarkkkrevkllllGqseSGKsTilkqlkllykkg.......fseeelat.wraviqlnivrsiktilealesleselsesfelqelkerl 98 
                 d +l++++++++     +lll+G s SGK++++k   ll +++       f+ee l + +  +++  +v+  k+i+++++    ++    +++ + e+l
  EFC39160.1  16 DYNLQQQQQQQQL---HHLLLMGVSNSGKTSFCKMSNLLLGGSmsknslkFHEELLSSmFSWLLFIICVK--KKIFNEIDYR-FPS----SKNLIDEKL 104
                 5555555554444...89*******************999888666666666665566455555555555..6777777663.233....455666666 PP

                 CCCS-HC..HHHH.......................HHCCHHC.....-HCHHHHHHHHC.CSHHHHHHHC.CG.CCTT--TTHHHHHCT......... CS
     G-alpha  99 dplkkve..asliaklssateee.............qeiefnp.....raevgedikaLw.ndpgiqelye.rr.nkiklednaeyFldd......... 165
                  ++ k++  ++ +++   +++ e             q+  ++p      a + ++i +Lw ++ ++ ++y   + nki+   ++ y++ +         
  EFC39160.1 105 LKIVKISivEQCSNEAGAGEN-EnggeqgdasrcllQQAIVKPellwsDAGMMQQISMLWaTETILHKIYTiLYyNKIS--PELLYLFGNtqvgsiisg 200
                 666444310332333333333.35899999999999777777777777788999******5555667777763335555..444444444465555555 PP

                 ..HHHHCSTT---......................................-CHHHHCS-----SEEEEEEEC.........T-TEE............ CS
     G-alpha 166 ..leritspdYlp......................................tddDilkarlktvGisetkfev.........dskle............ 203
                   l++  + + +p                                      ++   l a+  t G++e ++++         +   e            
  EFC39160.1 201 nvLDKNGNVNTVPkqpqwqhfehfnyvithcnqiaerlrrarkgfsdtelkSETEYLLASNMTRGFYESEIKIiterkststT---Enattstssskks 296
                 55444444444445556666666666667776666666777777777777766888888888888888888888777665440...1444455556667 PP

                 ..................EEEEEE-SSHHHHHGTCCCT CS
     G-alpha 204 ..................frivdvgGqrserkkWvpff 223
                                   ++++d +G rs rkkW++++
  EFC39160.1 297 kdseknalpqkpkpiirsLHMIDSAGVRSDRKKWKKIL 334
                 78888999999999*999****************9865 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0016
                 EEEEEEEGGGTT-B-SS- CS
     G-alpha 228 aiiFlvslsefdqvlyed 245
                 ai+++vsl +++q+  +d
  EFC39160.1 413 AILYFVSLTCYNQYSVDD 430
                 9************99887 PP

  == domain 3  score: 27.5 bits;  conditional E-value: 2.8e-10
                 SBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGG.C CS
     G-alpha 248 vnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgklsk.y 294
                 +n+l +sl+ F+  +n ++l+++p+iL+++K++ l++Kl   +ls+ y
  EFC39160.1 537 KNQLIDSLEFFNRTVNMPELEHVPFILVFTKKESLKRKLVYCDLSDaY 584
                 79*************************************887887744 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.0024
                 CHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHHH CS
     G-alpha 303 ndlesvlkylrnkFeeihkeksnnrrkiythftsatdtkevqkviesvr 351
                 + le  +ky++++F++  +++++ r++i +    +++ ++++k ++++ 
  EFC39160.1 795 EYLELNTKYIIKQFLNQVSNDEK-RNQIQIVTLDVFNREDMKKLLAELV 842
                 4567789**********998754.5589999999*********998774 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   0.0   0.00035       2.1      26      53 ..      19      46 ..      16      49 .. 0.89
   2 ?   -2.2   0.0      0.39   2.3e+03      64     107 ..     650     693 ..     642     702 .. 0.78
   3 ?    0.5   0.1     0.059   3.5e+02      51      92 ..     804     843 ..     801     845 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00035
        TniB 26 LleypkrkrmpnlllvGdsnnGKtmive 53
                L +  ++++ ++lll+G sn GKt+ ++
  EFC39160.1 19 LQQQQQQQQLHHLLLMGVSNSGKTSFCK 46
                677889999***************9876 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.39
        TniB  64 dedaekvpvlvvqappkpdekrlyaaiLealgaplkararvskl 107
                 ded+   pv+ ++  ++ +e +l +++++   ++  ++++ s+l
  EFC39160.1 650 DEDSVDSPVVCMEKVETFEEPKLSDQVIKPATTRNVTDESSSSL 693
                 56677789***************999999888776565555555 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.059
        TniB  51 ivekFarlhppekdedaekvpvlvvqappkpdekrlyaaiLe 92 
                 i+++F ++   ++de++++++++++++ ++ d k+l a++++
  EFC39160.1 804 IIKQFLNQ--VSNDEKRNQIQIVTLDVFNREDMKKLLAELVN 843
                 67777654..5677899999***************9999875 PP

>> PDZ_assoc  PDZ-associated domain of NMDA receptors
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.5       1.1   6.6e+03      21      47 ..     281     307 ..     276     314 .. 0.60
   2 ?   12.9   1.6   2.6e-05      0.15      38      65 ..     627     654 ..     601     657 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.1
   PDZ_assoc  21 sqhvdnhishssylgssesksaslppe 47 
                 s++ +  +s+ss  +s++s+++ lp+ 
  EFC39160.1 281 STTENATTSTSSSKKSKDSEKNALPQK 307
                 545555566666666655555557774 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 2.6e-05
   PDZ_assoc  38 esksas.lppetprrysPvpkgllgeddi 65 
                 +  s + +pp+tp++ sP+p +l +ed +
  EFC39160.1 627 Q-VSPQiPPPATPEKKSPIPSHLRDEDSV 654
                 2.233459******************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (846 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2307  (0.128674); expected 358.6 (0.02)
Passed bias filter:                      627  (0.0349713); expected 358.6 (0.02)
Passed Vit filter:                        70  (0.00390429); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.84u 0.31s 00:00:01.14 Elapsed: 00:00:00.45
# Mc/sec: 5630.16
//
Query:       EFC39161.1  [L=477]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (477 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       490  (0.02733); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.23s 00:00:00.73 Elapsed: 00:00:00.39
# Mc/sec: 3625.28
//
Query:       EFC39162.1  [L=445]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.012   15.1   3.5      0.012   15.1   3.5    2.0  2  CBP_BcsQ       Cellulose biosynthesis protein BcsQ
        1.8    9.0  37.9        9.4    6.7   6.5    3.4  3  DUF4200        Domain of unknown function (DUF4200)
        4.6    7.3   8.5        4.7    7.3   3.7    2.7  2  MHC2-interact  CLIP, MHC2 interacting
        4.9    7.8   9.9         20    5.8   3.0    3.0  2  MerR-DNA-bind  MerR, DNA binding
        5.3    6.3  19.9        3.5    6.9  10.6    2.2  2  DUF4407        Domain of unknown function (DUF4407)
        7.4    7.1  28.9       0.82   10.2  15.5    3.3  3  DUF16          Protein of unknown function DUF16


Domain annotation for each model (and alignments):
>> CBP_BcsQ  Cellulose biosynthesis protein BcsQ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.1   3.5   3.9e-06     0.012      95     198 ..     150     254 ..     140     276 .. 0.82
   2 ?   -0.8   0.3      0.29   8.8e+02      89     115 ..     339     365 ..     305     399 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 3.9e-06
    CBP_BcsQ  95 lqqlaekaeallaalkelkeqyrwillDlpagasaltrellaladlvllvvepdanchvrLhqqalpaaellLiNq.feaasqlqqDllqlWlqslrrl 192
                  q++++ +++l+++ ke k+qy+ i++D  + ++ l+ +l a+ d++ +v + +   + rL+q + ++a+ll  N+ +  + ++ +D    W + +++l
  EFC39162.1 150 DQKIDHLKGKLNKTKKECKKQYEHIVVDSVRTNNYLHANLCAQKDISKDVHTENEMLRTRLAQIESQNATLLNRNHeLAQQKEISDDWAERWHDRAQTL 248
                 4567778889999999999********************************************965555554444324456678999999999998888 PP

    CBP_BcsQ 193 lPlvih 198
                   lvi 
  EFC39162.1 249 SRLVIS 254
                 777775 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.29
    CBP_BcsQ  89 veekenlqqlaekaeallaalkelkeq 115
                 +ee e ++q +++ ++l +++k+l+eq
  EFC39162.1 339 QEEDEMIKQQRDTIQQLEQKIKQLQEQ 365
                 344444666677777777777777755 PP

>> DUF4200  Domain of unknown function (DUF4200)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   6.5    0.0031       9.4      11     102 ..     142     233 ..     139     236 .. 0.93
   2 ?    6.3   4.0    0.0042        12      12      96 ..     217     301 ..     212     322 .. 0.84
   3 ?    5.7  17.6    0.0063        19       3      93 ..     333     419 ..     332     435 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0031
     DUF4200  11 vqealeakkeeiqrleealkqreeelekkeqeleedllkfdkflkendakraralkkaeeerklkkekeaeikklkaeietlkseiekleek 102
                 v+++l++  ++i  l+ +l++ ++e +k+ + +  d ++ +++l  n   +++  k +++e+++ + + a+i+  +a + + + e+++ +e+
  EFC39162.1 142 VHLSLAKRDQKIDHLKGKLNKTKKECKKQYEHIVVDSVRTNNYLHANLCAQKDISKDVHTENEMLRTRLAQIESQNATLLNRNHELAQQKEI 233
                 6788999999***************************************************************9999998888888777765 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0042
     DUF4200  12 qealeakkeeiqrleealkqreeelekkeqeleedllkfdkflkendakraralkkaeeerklkkekeaeikklkaeietlksei 96 
                 +  l + + e+++++e  ++  e   ++ q l + ++ f+ +l e d k+++ l k +  + l +++ + +   ++eie + + +
  EFC39162.1 217 NATLLNRNHELAQQKEISDDWAERWHDRAQTLSRLVISFNTMLHEKDGKTQNSLDKEKLANLLSESRVKIVGSRETEIESVDKSL 301
                 567778899*********************************************9999888888888888888888887776554 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0063
     DUF4200   3 ekkremfevqealeakkeeiqrleealkqreeelekkeqeleedllkfdkflkendakraralkkaeeerklkkekeaeikklkaeietlk 93 
                 ++++ ++e +e+++++++ iq+le+++kq +e+++++++    + ++++   k+ ++  ++    ++e  k++ ++e+ i kl++e ++l 
  EFC39162.1 333 KNRKRLQEEDEMIKQQRDTIQQLEQKIKQLQEQVKREQS----NSINLQTVAKKQERTISELFSHINEADKMRLDREETILKLQQENDNLL 419
                 5789999999***********999999998888888875....57899*************************************998875 PP

>> MHC2-interact  CLIP, MHC2 interacting
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   3.7    0.0016       4.7      53      81 ..     344     372 ..     343     380 .. 0.89
   2 ?    1.5   0.2     0.099     3e+02      58      94 ..     405     441 ..     400     445 .] 0.85

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0016
  MHC2-interact  53 fvyqQkgqitkLektsenLklellrrklp 81 
                    ++ qQ++ i++Le++ ++L+++ +r+++ 
     EFC39162.1 344 MIKQQRDTIQQLEQKIKQLQEQVKREQSN 372
                    678******************99988765 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.099
  MHC2-interact  58 kgqitkLektsenLklellrrklpkaskPkkmalPll 94 
                    ++ i kL+++++nL  +   ++lp+ +k   +++P++
     EFC39162.1 405 EETILKLQQENDNLLNSVASKTLPTRRKSSYLSKPIT 441
                    678999********99999999999999988888875 PP

>> MerR-DNA-bind  MerR, DNA binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.6     0.013        40      38      63 ..     203     228 ..     188     230 .. 0.79
   2 ?    5.8   3.0    0.0065        20      31      62 ..     335     366 ..     318     368 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.013
                    HHHHHHHHHHHHHHHHHHHHHHHHHH CS
  MerR-DNA-bind  38 rallarklaeleeriaeLqalraeLa 63 
                    +++l+ +la++e + a+L     eLa
     EFC39162.1 203 NEMLRTRLAQIESQNATLLNRNHELA 228
                    58************999987777776 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0065
                    TTBHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  MerR-DNA-bind  31 appcqdvrallarklaeleeriaeLqalraeL 62 
                    +++ q+ +++++++++ +++  +++++l+++ 
     EFC39162.1 335 RKRLQEEDEMIKQQRDTIQQLEQKIKQLQEQV 366
                    46678888999999999999999999998875 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   1.8    0.0051        15     144     252 ..     148     229 ..     103     263 .. 0.52
   2 ?    6.9  10.6    0.0012       3.5     108     228 ..     297     424 ..     288     434 .. 0.71

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0051
     DUF4407 144 alqaeidaaearldalraeaqkeldgtkgtgttgvaGkgpaakekkaqldaaqaelaelkakld................atarlaalraelaeleaer 226
                 +                                           +++++d ++ +l++ k++ +                  a+l a+++  +++ +e 
  EFC39162.1 148 K-------------------------------------------RDQKIDHLKGKLNKTKKECKkqyehivvdsvrtnnyLHANLCAQKDISKDVHTEN 203
                 2...........................................3333344444444444433355555555555555553333333333333333333 PP

     DUF4407 227 akeraasqaaaaaddGllarlealdr 252
                 +  r++ ++ +++++ ll r++ l +
  EFC39162.1 204 EMLRTRLAQIESQNATLLNRNHELAQ 229
                 33333333333333333333333322 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0012
     DUF4407 108 Idaelaeeqqeeakelkeqlaaa..............ltaelaeleaqiaalqaeidaaearldalraeaqkeldgtkgtgttgvaGkgpaakekkaql 192
                 +d+ l++e ++++++l  +l ++               +++l+e+++ i++ + +i+++e+++++l++++++e ++  + +        ++ak+ ++ +
  EFC39162.1 297 VDKSLEDESKNSIASLHHKLLQEmlkvehdkwlppykNRKRLQEEDEMIKQQRDTIQQLEQKIKQLQEQVKREQSNSINLQ--------TVAKKQERTI 387
                 5555555555566666555555588888889999999999*******************************9999855433........5566666666 PP

     DUF4407 193 daaqaelaelkakld.atarlaalraelaeleaerak 228
                  ++   ++e+++ +  +++++ +l++e + l +  a+
  EFC39162.1 388 SELFSHINEADKMRLdREETILKLQQENDNLLNSVAS 424
                 6666666665554223777777777777776665554 PP

>> DUF16  Protein of unknown function DUF16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   1.9     0.021        62      36      70 ..     146     180 ..     125     215 .. 0.66
   2 ?    0.2   3.1      0.35     1e+03       3      79 ..     157     234 ..     156     264 .. 0.66
   3 ?   10.2  15.5   0.00028      0.82      28     103 ..     332     406 ..     271     407 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.021
                 HHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHH CS
       DUF16  36 Lkkieakvdklgeqinkleqkvekqgekikelkve 70 
                 L k ++k+d l+ ++nk +++ +kq e+i   +v+
  EFC39162.1 146 LAKRDQKIDHLKGKLNKTKKECKKQYEHIVVDSVR 180
                 56666777777777777777777777766544443 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.35
                 XXXXXXXXXX.X.XTTB..-BHHHHHHB-..BHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH... CS
       DUF16   3 sGsfneivKkiPvkteY..VTrkqlnefkdsnkqrLkkieakvdklgeqinkleqkvekqgekikelkveqkaqgeeln 79 
                 +G++n+++K+  ++ e+  V     n++ + n    k+i + v++ +e +     ++e q++ + + ++e  +q+e + 
  EFC39162.1 157 KGKLNKTKKECKKQYEHivVDSVRTNNYLHANLCAQKDISKDVHTENEMLRTRLAQIESQNATLLNRNHELAQQKE-IS 234
                 6777777777333333333445556778888888888999999999999998888999999988777777666655.54 PP

  == domain 3  score: 10.2 bits;  conditional E-value: 0.00028
                 B-..BHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.......HHHHHHHHHHHHHH.HHHHHC CS
       DUF16  28 fkdsnkqrLkkieakvdklgeqinkleqkvekqgekikelkveqkaqgeelnkvdetleliletLqkink.RlDsie 103
                 +k  n +rL++ ++ ++++   i++leqk+++++e++k+ + +    +   +k+++t+  +   +++ +k RlD+ e
  EFC39162.1 332 YK--NRKRLQEEDEMIKQQRDTIQQLEQKIKQLQEQVKREQSNSINLQTVAKKQERTISELFSHINEADKmRLDREE 406
                 44..8899999999999999999999999999999998766665555555779999999999999988777999866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (445 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3131  (0.174633); expected 358.6 (0.02)
Passed bias filter:                      603  (0.0336327); expected 358.6 (0.02)
Passed Vit filter:                       105  (0.00585643); expected 17.9 (0.001)
Passed Fwd filter:                        35  (0.00195214); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.86u 0.32s 00:00:01.18 Elapsed: 00:00:00.47
# Mc/sec: 2865.15
//
Query:       EFC39163.1  [L=257]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-16   59.8   5.7    1.7e-06   27.7   0.0    5.0  6  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.9   0.1    0.0025        45      11      49 .]       3      43 ..       1      43 [. 0.77
   2 !   22.9   0.5   2.9e-09   5.1e-05       5      49 .]      21      68 ..      17      68 .. 0.85
   3 !   24.5   0.1   9.2e-10   1.6e-05       1      44 [.      45      88 ..      45      93 .. 0.96
   4 !   27.7   0.0   9.2e-11   1.7e-06       1      46 [.      95     140 ..      84     141 .. 0.85
   5 ?   -1.2   0.0     0.097   1.7e+03      10      21 ..     150     163 ..     147     167 .. 0.61
   6 ?   -1.4   0.1      0.11     2e+03      15      19 ..     200     204 ..     190     219 .. 0.55

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.0025
     DUF4116 11 kngsalkylseeLknDkeivlkAvk...qngtalsyaseeLr 49
                ++g ++++++e+L+ D +iv++ +     n+ ++s++  eLr
  EFC39163.1  3 NYGVSFEKFDESLQ-DMQIVKESLInmrLNPASFSFIKLELR 43
                57889999999997.*******86622256668999887776 PP

  == domain 2  score: 22.9 bits;  conditional E-value: 2.9e-09
     DUF4116  5 vlea...vkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                v+e    ++ n+ ++ ++  eL++D+e+ + A+++n++ ++y++ e++
  EFC39163.1 21 VKESlinMRLNPASFSFIKLELRKDRELTKMALEINPHLFRYIYFEFK 68
                5555555778999******************************98875 PP

  == domain 3  score: 24.5 bits;  conditional E-value: 9.2e-10
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44
                DrE+ + a+++n+  ++y+  e+k+D e +l A+++ +++l ++
  EFC39163.1 45 DRELTKMALEINPHLFRYIYFEFKSDLEMALLAIRKLPHNLQFM 88
                9**************************************99997 PP

  == domain 4  score: 27.7 bits;  conditional E-value: 9.2e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 + Eiv  a++ +++ l+y+++ + n  eiv+ +vk++++ ++++ e
  EFC39163.1  95 NPEIVIPALELDPLTLQYVDPAIENYQEIVMNCVKRDPSTFRFVKE 140
                 45777777777777*****************************976 PP

  == domain 5  score: -1.2 bits;  conditional E-value: 0.097
     DUF4116  10 kkngsalkyls..e 21 
                 ++ +++++y++  e
  EFC39163.1 150 SIVPKCIRYIPrtE 163
                 55577888887445 PP

  == domain 6  score: -1.4 bits;  conditional E-value: 0.11
     DUF4116  15 alkyl 19 
                 +++y+
  EFC39163.1 200 YIHYI 204
                 34444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       491  (0.0273858); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.40u 0.25s 00:00:00.65 Elapsed: 00:00:00.38
# Mc/sec: 2027.46
//
Query:       EFC39164.1  [L=257]
Description: hypothetical protein NAEGRDRAFT_52666 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-38  133.1   0.1    1.4e-38  132.7   0.1    1.1  1  B9-C2     Ciliary basal body-associated, B9 protein


Domain annotation for each model (and alignments):
>> B9-C2  Ciliary basal body-associated, B9 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  132.7   0.1   8.1e-43   1.4e-38       1     169 []      75     243 ..      75     243 .. 0.94

  Alignments for each domain:
  == domain 1  score: 132.7 bits;  conditional E-value: 8.1e-43
       B9-C2   1 vhvigeIesAedfeaddnlfveyeldlgpdWklls......gleqgvTqtsraksdeksedvavfshpfdltlkstnlqgwPkllleVyslDswgrerv 93 
                 v+v+g I +Ae f+ + n+ + +++++g+dW++ +      +le+gvTq++ + ++ +  ++ ++++p+++ ++stn++gwPkl l V  ++ +g++++
  EFC39164.1  75 VIVNGVISHAE-FPGNMNISCSFQFVYGQDWEIARttgegvSLESGVTQVAMRPRGFN--SKYIWNFPLEICFRSTNPYGWPKLCLVV--QEGTGKQKI 168
                 689********.***********************666655555*********98855..789***********************99..7889***** PP

       B9-C2  94 eGYGvlalPtspGsheltvptwrpkgtslleelrsfflggspeledpklltkgksesrlglrtes.sGtvklrlnvv 169
                  GYG++++P  +G+h+l+v++++p++tsl+++++  + g  pe+ d+++++kg  e r+++rtes  G+v+++ln++
  EFC39164.1 169 IGYGWCQVPIGAGKHSLKVKLFKPQSTSLIQKWIGSVKGVAPEYFDSTMVCKG--EGREVTRTESvGGEVTIELNIM 243
                 **********************************************99*****..**********99********96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (257 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       834  (0.0465168); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.32s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1578.16
//
Query:       EFC39165.1  [L=277]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-55  187.7  20.7    3.1e-55  187.4  20.7    1.0  1  ELO       GNS1/SUR4 family
  ------ inclusion threshold ------
       0.37   10.9   2.3        2.9    8.0   0.0    2.7  2  PspB      Phage shock protein B


Domain annotation for each model (and alignments):
>> ELO  GNS1/SUR4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  187.4  20.7   3.5e-59   3.1e-55       3     248 ..      17     272 ..      15     274 .. 0.88

  Alignments for each domain:
  == domain 1  score: 187.4 bits;  conditional E-value: 3.5e-59
         ELO   3 lsspkvpiliallYlllvllgpklmk...nrkpf...klkalvilhnlflavlSavgfvgmvkallevlkk.......kglvdllckddssdegrlrng 88 
                 +s++ +p ++++ Y l  +l+p +mk   n+ p+    l+ ++ +hn+fl+vlS+++++g+v + +ev+++       ++l +l+c    + ++r+ +g
  EFC39165.1  17 ISHWIYPATAVVGYGLSLYLLPLYMKkvrNNTPMkhpLLEMFIKFHNIFLSVLSLIMVLGFVGEAVEVVNEipeasfmEKLSALTC----DVPNRMGKG 111
                 57999*********************765445557779************************766777755788888889999999....7899***** PP

         ELO  89 llaflvllfylsKfvEllDTvflvlrkkqvsfLhvYHHatvmllmwaglrfatssgivfivllNsfvHaimYtYYflsalg.....akklvvpwkrliT 182
                  + f++++fylsK++EllDTvfl ++ k ++fLh++HH++++ll+w+ +  + s++++f  +lN +vH+imY+Y+++++++        +  ++k++iT
  EFC39165.1 112 AVPFWLYIFYLSKYYELLDTVFLMIKCKSLTFLHTFHHMITLLLCWYVILEK-SQMMWFPSTLNAGVHVIMYFYFYVCTVKnspifTPGCLNVIKPWIT 209
                 ****************************************************.99999999*****************9997777655556667***** PP

         ELO 183 slQilQfvvgl.laavyllvsytlkkvgCdtsqtpkaairlnllyllslllLFlnffiksylkkkkk 248
                 ++Qi+Qfv+ l +  v+l ++y ++ ++C+ +++p   ++l  l ++ +l+LFlnf+i+sy +kk+ 
  EFC39165.1 210 RMQIIQFVFDLvVPKVWLWFKYGDN-QTCAGNYYP---FFLVDLTVAAFLALFLNFYIQSYKRKKTD 272
                 ***********66666666665555.9**888555...7777778899***************9975 PP

>> PspB  Phage shock protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.6     0.038   3.4e+02      17      28 ..     113     124 ..     112     128 .. 0.88
   2 ?    8.0   0.0   0.00032       2.9       7      28 ..     213     234 ..     208     240 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.038
        PspB  17 apiWLiLHYrsk 28 
                 +p WL ++Y sk
  EFC39165.1 113 VPFWLYIFYLSK 124
                 699*******98 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00032
        PspB   7 vpliifvlfVapiWLiLHYrsk 28 
                 ++  +f l+V  +WL++ Y   
  EFC39165.1 213 IIQFVFDLVVPKVWLWFKYGDN 234
                 5667999************765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       553  (0.0308439); expected 358.6 (0.02)
Passed bias filter:                      204  (0.0113782); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1798.43
//
Query:       EFC39166.1  [L=227]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (227 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       535  (0.0298399); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 1491.68
//
Query:       EFC39167.1  [L=278]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-05   23.9   2.2        3.5    7.9   0.1    5.1  5  LRR_6     Leucine Rich repeat
  ------ inclusion threshold ------
      0.023   15.0   0.1        6.2    7.2   0.0    3.2  3  PriX      Primase X
       0.15   12.5  15.1        1.2    9.6   0.2    4.6  6  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.34     2e+03       1      23 [.     106     128 ..     106     129 .. 0.73
   2 ?    2.9   0.0     0.025   1.5e+02       3      18 ..     135     150 ..     133     152 .. 0.88
   3 ?    1.5   0.0     0.068   4.1e+02       3      23 ..     162     183 ..     160     184 .. 0.88
   4 !    6.2   0.1     0.002        12       4      21 ..     191     208 ..     188     211 .. 0.82
   5 !    7.9   0.1   0.00058       3.5       4      18 ..     218     232 ..     217     234 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.34
       LRR_6   1 snthLteLdLsgNdIgDeGaeaL 23 
                 +++++t+L     d++D+ + aL
  EFC39167.1 106 KCRNITSLRFGRMDFDDAAIVAL 128
                 58999999887777777666665 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.025
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 t+++eL+L + +I+ +
  EFC39167.1 135 TNVKELELFCSNISPD 150
                 799*********9875 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.068
       LRR_6   3 thLteLdLsgNd.IgDeGaeaL 23 
                  +L++L +  N  +g + +++L
  EFC39167.1 162 LTLETLIIHNNPdFGPKSVKSL 183
                 599********99999999998 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.002
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                 +L+ L+L    IgDeG++
  EFC39167.1 191 NLKRLELVNTFIGDEGLK 208
                 68888888888*****98 PP

  == domain 5  score: 7.9 bits;  conditional E-value: 0.00058
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 h++ L+L+gN ++D+
  EFC39167.1 218 HVKRLNLQGNLLTDS 232
                 99***********96 PP

>> PriX  Primase X
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.012        72      19      35 ..     125     141 ..     113     146 .. 0.85
   2 ?    7.2   0.0     0.001       6.2      22      36 ..     183     197 ..     164     226 .. 0.82
   3 ?   -1.9   0.0      0.71   4.2e+03      22      41 ..     250     267 ..     241     275 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.012
                 HHHHTHHHHHHHTS--- CS
        PriX  19 lilyvisrYLvnvkkls 35 
                 ++  v s++L nvk+l+
  EFC39167.1 125 IVALVESPFLTNVKELE 141
                 566799********996 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.001
                 HTHHHHHHHTS---H CS
        PriX  22 yvisrYLvnvkklse 36 
                  v s+YLvn+k+l+ 
  EFC39167.1 183 LVQSPYLVNLKRLEL 197
                 699*********985 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.71
                 HTHHHHHHHTS---HHHHHH CS
        PriX  22 yvisrYLvnvkklseeealk 41 
                  v   YL  vk l++++al+
  EFC39167.1 250 VVCGNYL--VKSLNKKKALE 267
                 5666777..57888777765 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.1   6.5e+03      19      29 ..      45      54 ..      39      65 .. 0.75
   2 ?   -0.8   0.0       0.4   2.4e+03      20      29 ..     103     114 ..      82     122 .. 0.57
   3 ?    1.6   0.1     0.069   4.1e+02      22      36 ..     134     147 ..     127     157 .. 0.70
   4 ?    4.2   0.3      0.01        61       2      34 ..     136     172 ..     135     179 .. 0.59
   5 ?    9.6   0.2   0.00021       1.2       3      38 ..     164     204 ..     162     209 .. 0.86
   6 ?    7.0   2.1    0.0014       8.2       3      39 ..     219     260 ..     217     268 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.1
                HHH-TT--EEE CS
       LRR_4 19 leklpnLkeLd 29
                ++ lp  k+L+
  EFC39167.1 45 PS-LPRIKKLN 54
                34.88888887 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.4
                 H..H-TT--EEE CS
       LRR_4  20 e..klpnLkeLd 29 
                 +  k+ n ++L 
  EFC39167.1 103 NseKCRNITSLR 114
                 233455555554 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.069
                 -TT--EEE-.-S--- CS
       LRR_4  22 lpnLkeLdLsgNnli 36 
                 l+n keL L ++++i
  EFC39167.1 134 LTNVKELEL-FCSNI 147
                 899999998.55444 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.01
                 S--EEE--.SS---.E-S-.HHH-TT...--EEE-.-S- CS
       LRR_4   2 nLevLdLs.nNqlt.dipl.leklpn...LkeLdLsgNn 34 
                 n ++L L+ + +++ d  + l+++ +   L++L + +Nn
  EFC39167.1 136 NVKELELFcS-NISpDSFGmLANCSKlltLETLII-HNN 172
                 6677777733.699773336556666222555546.665 PP

  == domain 5  score: 9.6 bits;  conditional E-value: 0.00021
                 --EEE--SS-......--E-S-.HHH-TT--EEE-.-S----- CS
       LRR_4   3 LevLdLsnNq......ltdipl.leklpnLkeLdLsgNnlitd 38 
                 Le+L ++nN       ++++   ++ l nLk L L  N++i+d
  EFC39167.1 164 LETLIIHNNPdfgpksVKSLVQsPY-LVNLKRLEL-VNTFIGD 204
                 999****998999999**9999677.*********.6668876 PP

  == domain 6  score: 7.0 bits;  conditional E-value: 0.0014
                 --EEE--SS---E-S-..HHH-TT--EEE...-.-S-----G CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLd...LsgNnlitdl 39 
                  + L+L++N ltd +   l++    + Ld   + gN l+++l
  EFC39167.1 219 VKRLNLQGNLLTDSSYqlLRNTQWIRDLDnlvVCGNYLVKSL 260
                 689**********88887664444555555444588555665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (278 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       511  (0.0285013); expected 358.6 (0.02)
Passed bias filter:                      300  (0.0167327); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 1803.36
//
Query:       EFC39168.1  [L=724]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-07   31.3  16.8    3.6e-07   30.2  16.8    1.6  1  Zn_clus          Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.2  16.8     2e-11   3.6e-07       2      39 ..     196     232 ..     195     233 .. 0.96

  Alignments for each domain:
  == domain 1  score: 30.2 bits;  conditional E-value: 2e-11
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 aC++Crk+++KCd+k P C+ C ++++eC  y+es+++
  EFC39168.1 196 ACEPCRKQHRKCDKKLPCCTACTQRSVECI-YRESKRN 232
                 9*****************************.***9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (724 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1070  (0.0596798); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 4190.60
//
Query:       EFC39169.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.8e-15   55.2   0.1    3.8e-14   53.0   0.1    2.2  1  Ank_2           Ankyrin repeats (3 copies)
    5.3e-12   44.8   0.2    1.9e-05   24.7   0.0    2.9  2  Ank_3           Ankyrin repeat
    7.6e-10   38.8   0.2    0.00083   19.7   0.0    2.5  2  Ank             Ankyrin repeat
    1.7e-09   37.7   0.0     0.0014   18.9   0.0    2.5  2  Ank_5           Ankyrin repeats (many copies)
    4.2e-09   36.8   0.0     0.0042   17.6   0.0    2.5  2  Ank_4           Ankyrin repeats (many copies)
  ------ inclusion threshold ------
       0.02   14.6   1.6        7.9    6.3   0.0    3.5  4  DnaA_N          DnaA N-terminal domain
       0.11   11.4   7.1       0.16   10.9   7.1    1.3  1  Paramyxo_ncap   Paramyxovirus nucleocapsid protein
       0.21   11.7   4.0       0.28   11.3   4.0    1.3  1  DDHD            DDHD domain
        4.8    5.8  11.1          6    5.5  11.1    1.1  1  Presenilin      Presenilin


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.0   0.1   1.9e-17   3.8e-14       3      80 ..       8     106 ..       6     108 .. 0.71

  Alignments for each domain:
  == domain 1  score: 53.0 bits;  conditional E-value: 1.9e-17
       Ank_2   3 lAakngnlelvklLlegadpn.k.ngktaLhyAakngnleivklLleh...............ad...ndgrtpLhyAarsghleivklLlek.gadin 80 
                  Aa++gn   +k   + +++n +  +kt L+ A+++g+leivklLl+                ++   ++ ++pLh+A+++g+leivklLl++ +++in
  EFC39169.1   8 DAANSGNVAEFKKYFKPTKVNeSdRNKTLLYMACERGHLEIVKLLLNCggldvnkgftyhfisIKlgqEEMESPLHIACEKGRLEIVKLLLQSpNIKIN 106
                 68888877444444456777753478********************945544334444445541144455779******************76566665 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.1   2.2e-06    0.0044       2      30 ..      33      61 ..      32      62 .. 0.84
   2 !   24.7   0.0   9.4e-09   1.9e-05       3      30 ..      79     106 ..      77     107 .. 0.94

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 2.2e-06
       Ank_3  2 GetpLhlAarsgnleivkfLlenkgadvn 30
                + t+L++A++ g+leivk+Ll+  g dvn
  EFC39169.1 33 NKTLLYMACERGHLEIVKLLLNCGGLDVN 61
                579*******************4466665 PP

  == domain 2  score: 24.7 bits;  conditional E-value: 9.4e-09
       Ank_3   3 etpLhlAarsgnleivkfLlenkgadvn 30 
                 e+pLh+A++ g+leivk+Ll+ +++ +n
  EFC39169.1  79 ESPLHIACEKGRLEIVKLLLQSPNIKIN 106
                 79*******************9999988 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.1   4.2e-06    0.0084       3      27 ..      34      60 ..      33      62 .. 0.84
   2 !   19.7   0.0   4.2e-07   0.00083       4      29 ..      80     103 ..      78     107 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 4.2e-06
                BBHHHHHHHHTTHHHHHHHH.TT.TST CS
         Ank  3 nTPLHlAatngkkriiklLL.hG.Anl 27
                 T L +A+ +g+++i+klLL +G  ++
  EFC39169.1 34 KTLLYMACERGHLEIVKLLLnCGgLDV 60
                599*****************8862455 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 4.2e-07
                 BHHHHHHHHTTHHHHHHHHTTTSTTC CS
         Ank   4 TPLHlAatngkkriiklLLhGAnlna 29 
                 +PLH+A+  g ++i+klLL++  +n+
  EFC39169.1  80 SPLHIACEKGRLEIVKLLLQS--PNI 103
                 7******9999********65..555 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   4.5e-06    0.0089      11      42 ..      29      55 ..      20      62 .. 0.80
   2 !   18.9   0.0   7.2e-07    0.0014      17      40 ..      79      99 ..      69     107 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.5e-06
       Ank_5 11 rldgggntpLhvAakygaadvvrlLlargadl 42
                 +d+++ t L +A+++g++++v+lLl    ++
  EFC39169.1 29 ESDRNK-TLLYMACERGHLEIVKLLL----NC 55
                455666.*******************....44 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 7.2e-07
       Ank_5 17 ntpLhvAakygaadvvrlLlarga 40
                ++pLh+A+++g++++v+lLl   +
  EFC39169.1 79 ESPLHIACEKGRLEIVKLLL---Q 99
                48******************...3 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0     5e-06    0.0099      27      55 .]      27      53 ..       4      53 .. 0.77
   2 !   17.6   0.0   2.1e-06    0.0042       3      27 ..      80     105 ..      78     111 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 5e-06
       Ank_4 27 inaqdnrsGetalhiAakrgnveilklLl 55
                +n++  ++  t+l++A+ rg++ei+klLl
  EFC39169.1 27 VNES--DRNKTLLYMACERGHLEIVKLLL 53
                4444..3477******************8 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 2.1e-06
       Ank_4   3 taLhyaaisgrlelvrlLlek.gadi 27 
                 ++Lh a+++grle+v+lLl++ ++ i
  EFC39169.1  80 SPLHIACEKGRLEIVKLLLQSpNIKI 105
                 67888888888888888887544444 PP

>> DnaA_N  DnaA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.0     0.004       7.9      18      37 ..      16      37 ..      10      42 .. 0.80
   2 ?   -1.9   0.1       1.5     3e+03       6      22 ..     118     134 ..     117     140 .. 0.76
   3 ?   -1.8   0.0       1.3   2.7e+03      41      51 ..     207     217 ..     198     218 .. 0.81
   4 ?    5.2   0.0    0.0089        18      39      59 ..     275     295 ..     261     299 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.004
      DnaA_N 18 qsfdtWikplklfalknng..l 37
                ++f++++kp+k+++ + n+  l
  EFC39169.1 16 AEFKKYFKPTKVNESDRNKtlL 37
                57**********9998888644 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.5
      DnaA_N   6 avlerLkkelgeqsfdt 22 
                 +++++L +++++++ ++
  EFC39169.1 118 KIKKELNEKVEKDKIKK 134
                 78888888888887766 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.3
      DnaA_N  41 vpneFardwie 51 
                   neF ++++e
  EFC39169.1 207 LENEFQKEYLE 217
                 6799*999986 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0089
      DnaA_N  39 livpneFardwiesnYldria 59 
                 liv  eF++ ++++ Yl +i+
  EFC39169.1 275 LIVLDEFIKTYLNQEYLTDIQ 295
                 778889************997 PP

>> Paramyxo_ncap  Paramyxovirus nucleocapsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   7.1     8e-05      0.16     411     512 ..     110     214 ..      61     226 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8e-05
  Paramyxo_ncap 411 gpkqaqvsflrsdrseeeqkraskke..ekrek.qsrkearesskedkkkeatdeeaaslsketlldvdttsesdedpleskksaeallklralak 503
                      +  ++s ++++ +e+ +k++ kke  ek+e  ++++e++e+ +++++k++ ++e+ ++++e   + d+t+e++ + +e+ +s   +  ++ l +
     EFC39169.1 110 KVNGKEISKIKKELNEKVEKDKIKKEilEKQEPlEKHDENQETLEQQEEKHDENQETLEKQDENIKEQDETQETNIERQEETQSNSQINAIKVLCT 205
                    55566788888888888888877776223333313444555555666666677777778888999999**************************** PP

  Paramyxo_ncap 504 iledseaee 512
                    +le++ ++e
     EFC39169.1 206 VLENEFQKE 214
                    *99876655 PP

>> DDHD  DDHD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   4.0   0.00014      0.28      90     170 ..     112     201 ..      60     302 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00014
        DDHD  90 lkesltsigaalkqkvsglvsslsa.llnrs..lelaeeesaslaessksherasesskasqeskaaesstasssaksskaee........k 170
                  ++++++i+++l++kv++  +++++ +l+++  le ++e++++l++++++h +++e+ ++++e+ +++++t++++ +++++++        k
  EFC39169.1 112 NGKEISKIKKELNEKVEK--DKIKKeILEKQepLEKHDENQETLEQQEEKHDENQETLEKQDENIKEQDETQETNIERQEETQsnsqinaiK 201
                 455666666666665432..223223333332244444555555555555555555444444444444433333333332222223333330 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5  11.1     0.003         6     235     316 ..     123     194 ..      85     248 .. 0.48

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.003
  Presenilin 235 seeeeeaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaeesseekeseessesseeeeeeeeeeeese 316
                  +e+ e++k k+e+ e+++  e+++e++e+ +q++e+++e++e+ ++++++ +e++e++e          ++ e++ee++s+
  EFC39169.1 123 LNEKVEKDKIKKEILEKQEPLEKHDENQETLEQQEEKHDENQETLEKQDENIKEQDETQE----------TNIERQEETQSN 194
                 112222222222222222222222222222222222222222222222222222222222..........222222222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3538  (0.197334); expected 358.6 (0.02)
Passed bias filter:                      629  (0.0350828); expected 358.6 (0.02)
Passed Vit filter:                       149  (0.00831056); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.91u 0.39s 00:00:01.30 Elapsed: 00:00:00.59
# Mc/sec: 1761.21
//
Query:       EFC39170.1  [L=657]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (657 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       679  (0.0378716); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.51
# Mc/sec: 3858.40
//
Query:       EFC39171.1  [L=298]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (298 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1553  (0.0866194); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 1632.89
//
Query:       EFC39172.1  [L=2288]
Description: rasGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-31  110.2   7.8      1e-30  107.3   1.4    3.1  2  RasGEF    RasGEF domain
    1.5e-26   93.4   1.0    1.5e-26   93.4   1.0    2.6  2  DOCK-C2   C2 domain in Dock180 and Zizimin proteins
     0.0028   17.8   0.9     0.0028   17.8   0.9    4.8  7  RasGEF_N  RasGEF N-terminal motif


Domain annotation for each model (and alignments):
>> RasGEF  RasGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.6    0.0037        22      11      91 ..    1521    1617 ..    1517    1647 .. 0.76
   2 !  107.3   1.4   1.7e-34     1e-30       1     176 [.    2039    2225 ..    2039    2226 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0037
      RasGEF   11 aelfskikpeellgsawsked...........rs.....pnveaviarfnrlsnwvaseilseeslkkRakviekf.ikiakecrklnNfnslmail 90  
                   +lf ki+++e  +s+ ++ +           ++     +++   +++fn++   +++  l + +  +R  +ie++  k+    ++ln+++  + +l
  EFC39172.1 1521 LDLFIKIDYDERYQSREQR-ErvigilfnslvDNfftkgEELLLKLKQFNEINIILSTIMLWTMRNCNRDTLIEWWkKKTLYFANDLNDISIIFYVL 1616
                  5788999999999977333.347777775555114444566666799*****************************555556577888888777666 PP

      RasGEF   91 s 91  
                   
  EFC39172.1 1617 K 1617
                  5 PP

  == domain 2  score: 107.3 bits;  conditional E-value: 1.7e-34
      RasGEF    1 elAeqltlieaelfskikpeellgsawsked...rs...pnveaviarfnrlsnwvaseilseeslkkRakviekfikiakecrklnNfnslmails 91  
                  e+A+qltl+ea++f kikp+e+ +    ++d   r+   +n+  + ++f+ + +w  +++l +++ ++R kv++k++  a+ c+++nNf ++ma l 
  EFC39172.1 2039 EIAHQLTLLEAKFFLKIKPYEFYYIE--SKDkeiREkysSNILFMQEHFKLVQHWANEMVLVQTNDRDRKKVFTKVLCSAQSCYQQNNFFGFMALLG 2133
                  79**********************44..4443562256699******************************************************** PP

      RasGEF   92 aLqsspvsrLkktweavskkslktleeleel...mspennfknyrealkssasskpciPflglyltdltfieegnpdtl......egk.iNfeKr 176 
                  aL s++v+r k+  e  + +  k+++ele +   + ++++++++ + l+++  + pc+P+lg + ++++f++egn+  l      ++k iN++ +
  EFC39172.1 2134 ALRSTSVYRIKELYEDNK-EVHKLYQELEDCqkkVINSKEIAAMYDSLSEK--QLPCVPYLGSFQSQVLFTKEGNKPLLdhpkspNKKvINYKMM 2225
                  ************988665.55666776666511155566777777888877..899******************877667777778888999876 PP

>> DOCK-C2  C2 domain in Dock180 and Zizimin proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.6   3.6       2.8   1.7e+04     146     194 ..     145     188 ..      93     189 .. 0.64
   2 !   93.4   1.0   2.5e-30   1.5e-26       2     194 ..     982    1209 ..     981    1210 .. 0.78

  Alignments for each domain:
  == domain 1  score: -4.6 bits;  conditional E-value: 2.8
     DOCK-C2 146 ppsgYlslpssrtssseeqkgpsekwldnskdtfkvrtklcSTiltqde 194
                 + + Y+ ++++ + ++++++++++     ++++ + +++  +Tilt+de
  EFC39172.1 145 N-QFYVAATNNLSAQEQNNNNNNS----ATRSSQTNNSNTSTTILTEDE 188
                 2.3676555443333333333333....378888888888889988887 PP

  == domain 2  score: 93.4 bits;  conditional E-value: 2.5e-30
     DOCK-C2    2 gdvrNdlYvtlksgefsskgskssakniqvtvevrds...............dger.lekaiylgsgeelvsefrsvvlyhn.kqptfneeiKialp 81  
                  + ++N +Y++lk ++++   + +s+k++ ++v vr++               ++ + + k+++ + +++l+++ +s+++ ++ k+ +f +eiK++l 
  EFC39172.1  982 MVYKNMMYIHLKFARLG---GVKSCKHLLIEVAVRENdlskpspedfisttnTE-SkMLKRLIGKYNNKLQRYQFSSLANNTkKNVHFVDEIKVDLL 1074
                  679*************5...6889*************88888888777765322.24668888679999999666666665559**********996 PP

     DOCK-C2   82 ielt....ekhHLlFtfrhvsceekkk.............ekdkeeeekpfgyaflpLlk.....edgraflk..................dgehel 138 
                    +      +hHLlFtf+ +++e++k               ++++++++++gyaflpL       e                          ++++l
  EFC39172.1 1075 GLTSenitAGHHLLFTFYSIDVEDSKGkvqkymdsldirnAHFGSSNRNILGYAFLPLAAknsvyE------AdktifgdllvnymairqsVTNETL 1165
                  544433349*************98877*************99999**************9444441......24555555666665555556***** PP

     DOCK-C2  139 pvykkelppsgYlslpssrtssseeqkgpsekwldnskdtfkvrtklcSTiltqde 194 
                  ++y  +l+p gYls++++      +  +++ +    +k+++k++ +l+STi + de
  EFC39172.1 1166 MIYS-KLNP-GYLSASEK------DLMSNKLT----EKAKLKIDANLVSTIQPPDE 1209
                  ***6.4999.***97644......22223333....89**************9997 PP

>> RasGEF_N  RasGEF N-terminal motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.4      0.51   3.1e+03      51      71 ..     160     181 ..     135     200 .. 0.57
   2 ?   -3.5   0.3       2.1   1.2e+04      62      70 ..     281     300 ..     237     313 .. 0.51
   3 ?   -3.8   0.1       2.7   1.6e+04      38      68 ..    1032    1059 ..    1025    1080 .. 0.54
   4 ?   -1.3   0.1      0.44   2.6e+03      25      51 ..    1211    1252 ..    1197    1312 .. 0.52
   5 ?   -3.7   0.0       2.4   1.4e+04      35      50 ..    1555    1570 ..    1541    1617 .. 0.71
   6 ?   -3.4   0.2       1.9   1.1e+04      27      50 ..    1713    1734 ..    1686    1770 .. 0.51
   7 !   17.8   0.9   4.8e-07    0.0028      16      76 ..    1850    1907 ..    1831    1962 .. 0.62

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.51
    RasGEF_N  51 inppnnlesd.esnswnsksss 71 
                 +n++nn++++ +s+++ns++s+
  EFC39172.1 160 QNNNNNNSATrSSQTNNSNTST 181
                 2222222222133555555554 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 2.1
    RasGEF_N  62 s...........nswnskss 70 
                 s           ns+ns+++
  EFC39172.1 281 SsslnqtpkrssNSNNSNTN 300
                 03333444432233333333 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 2.7
    RasGEF_N   38 paeLlekLieryeinppnnlesdesnswnsk 68  
                   +++l+ Li  y+   ++ + ++ s+++n++
  EFC39172.1 1032 ESKMLKRLIGKYN---NKLQRYQFSSLANNT 1059
                  4556777777773...222222222222222 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.44
    RasGEF_N   25 letFLltyrsFttpaeLlekLierye...............i 51  
                  l+ +++ y+ Ft+++ L +  i  y+               +
  EFC39172.1 1211 LQLLFAAYNAFTKSTSLQKSAILEYIvyhlynkivlidfslC 1252
                  556677788888877776544444443444444444444440 PP

  == domain 5  score: -3.7 bits;  conditional E-value: 2.4
    RasGEF_N   35 FttpaeLlekLierye 50  
                  Ft+ +eLl kL ++ e
  EFC39172.1 1555 FTKGEELLLKLKQFNE 1570
                  7777777777776554 PP

  == domain 6  score: -3.4 bits;  conditional E-value: 1.9
    RasGEF_N   27 tFLltyrsFttpaeLlekLierye 50  
                  t +++ +s +t  eL+++ +er  
  EFC39172.1 1713 TCFIMVKSVMT--ELITNFAERIS 1734
                  33444444443..45555555553 PP

  == domain 7  score: 17.8 bits;  conditional E-value: 4.8e-07
    RasGEF_N   16 skrlldd.dfletFLltyrsFttpaeLlekLieryeinppnnl.esd.esnswnsksssnirlr 76  
                  ++++ ++ +f + F lty+ F +p+ +++ Li+ y++ +++++  s+ ++n+++ k      ++
  EFC39172.1 1850 ENDIENTeNFSQMFYLTYNLFSSPEHIIDILISKYKHLNQQSKmDSSkKDNLFIAK------IN 1907
                  33444444***************************753333331222133333322......22 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1263  (0.0704445); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.22u 0.33s 00:00:01.55 Elapsed: 00:00:00.55
# Mc/sec: 12606.89
//
Query:       EFC39173.1  [L=561]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-61  207.8   0.1    3.3e-61  207.5   0.1    1.1  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  207.5   0.1   1.8e-65   3.3e-61      26     440 ..      81     531 ..      53     548 .. 0.86

  Alignments for each domain:
  == domain 1  score: 207.5 bits;  conditional E-value: 1.8e-65
                 HHHHHHHH.-SEEEEEETT.EEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGH..HHHHHHHHHHHHHHTSHSTT.THHHHHH CS
        p450  26 lrklqkky.gpifrlklgs.kpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfang..ekwkklRrfltptltsfgkl.sleelve 119
                 l+ ++k    +++++++g+  ++ v  +  ++ke+l+kk + +s+    a +        g +++ a++  + wkk+R++ +p + s+  l ++  ++ 
  EFC39173.1  81 LEAFKKNPnAKVVKVQMGGsCQILVARDQALIKEILVKKYKTISKGESLAPVGL-----FGPNMFSADSsnPLWKKHRTMANPIFSSSSHLkNVFRVTL 174
                 344444446789999998758999999999*********888887545555554.....555555555556*****************7778******* PP

                 HHHHHHHHHHHCCCCHCS.....EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHHHHHCHHHHCCCCCHHHTCCSCHHHHHHHHHH CS
        p450 120 eeaedlveklrkkagess.....elditellskaaldvigsilFgarfdlledeklselvkaveelssllskssvqllllfpllkylptkllrklkeav 213
                 ee++++++ +++  g+ +     ++++t+ +  ++l+vi++++F   ++ + d+ ++  +++ + + +ll    + +++++ l+ y p  +++++++a 
  EFC39173.1 175 EETKKMLNFWKSIYGSETdgsirKVNVTNEFKSITLNVINRVAFDYDVG-IFDNGAKYRDELHDWVTDLLTGLIYTFVMPKFLFEYAPFGIFKRFRDAK 272
                 ***********999999999999**************************.66665655555555555566555666677777999************** PP

                 HHHHHHHHHHHHHHHHCHCHC...SCSSCSHHHHHHHHC.TTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCC CS
        p450 214 kklkdlldklieerretldsa...kksrrdfldalllak.kekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlg 308
                 +++k  +  +i ++++++ds+   +k++ d+l +ll+++  ++++++kls++el   ++ ++faG++T+s+ l ++L  Lakn++ q+++  Eid+ ++
  EFC39173.1 273 ERFKVATLTMIDKKQKEMDSNefiQKDDEDLLTLLLKSSaAASSEDEKLSRDELLSAIFIVFFAGFETSSASLNFMLRMLAKNQQFQDEVVREIDQEIK 371
                 ************************99*************855555579**************************************************9 PP

                 TTTT-HHHHC.CT-HHHHHHHHHHHHHSCSSTTEEEEESSS..CEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTS........... CS
        p450 309 dkreptyddl.qklpyldavikEtLRlhpvvplllpRevtk..dvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRFldekg........... 393
                 +++ ++++ + +klp+l+ +ikE+LR  ++v  +  R++ +     i+g++ p+Gt v ++  + h+  ++    + Fdp RF d+k            
  EFC39173.1 372 HADDISFELItNKLPLLTSFIKEVLRTKTPVG-GGARVINSkkGDFINGVHYPQGTSVTISYFSQHYYAKEG--HDDFDPYRFMDKKStstaaatsdev 467
                 9999****98468*******************.999*997766899********************977764..469**********9*********** PP

                 .................CTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTS CS
        p450 394 .................nskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpe 440
                                  n +  s+  lPF+ GpR CiG+r+A +e+kl+l+ lL+n++++++++
  EFC39173.1 468 genetgetygkgpmgelNIDFGSDGILPFSIGPRDCIGKRMALLEMKLILVFLLKNYRLKVPKG 531
                 *****************77799**************************************9654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (561 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       793  (0.04423); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 3214.45
//
Query:       EFC39174.1  [L=406]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.1e-40  137.7  12.0    6.8e-40  137.3  12.0    1.1  1  G-alpha    G-protein alpha subunit
    0.00011   21.7   1.2      0.019   14.5   0.1    2.9  3  Arf        ADP-ribosylation factor family
      0.005   15.6   0.2       0.55    8.8   0.0    2.2  2  GDA1_CD39  GDA1/CD39 (nucleoside phosphatase) family
  ------ inclusion threshold ------
      0.043   13.8   0.0       0.17   11.9   0.0    1.9  2  ASXH       Asx homology domain
      0.043   14.0   0.9        5.8    7.2   0.0    2.8  2  DUF1623    Protein of unknown function (DUF1623)


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.3  12.0   1.9e-43   6.8e-40      25     352 ..      30     357 ..       4     359 .. 0.79

  Alignments for each domain:
  == domain 1  score: 137.3 bits;  conditional E-value: 1.9e-43
                 EEEEEESTTSSHHHHHHHHHHHCS--..--HHHH.HCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH..........H CS
     G-alpha  25 kllllGqseSGKsTilkqlkllykkg..fseeel.atwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliaklssateeeq 120
                  +++lG+++SG sT++  ++++ +k+  +s+++  ++  +++++ +++ + tile+ e+  +  + + +   + e+l++  ++++s            q
  EFC39174.1  30 EWIILGTADSGTSTFYYMIERILRKNrnYSNRDEfNHDLQIVCSLMIKRLWTILEESERNRIIDMIPKSFGPCLENLNDKSNIDDS------------Q 116
                 689*****************77766667888877577999*******************544443333666777777777777776............4 PP

                 HCCHHC-HCHHHHHHHHCCSHHHHHHHCCG.CCTT..--TTHHH........HHCT....HHHHCST.T----CHHHHCS-----SEEEEEEECT-TEE CS
     G-alpha 121 eiefnpraevgedikaLwndpgiqelyerr.nkik..lednaey........Fldd....leritsp.dYlptddDilkarlktvGisetkfevdskle 203
                  +ef    +++  +  +wn p+++e +e + n i+  +++n++          l++    ++ri+s+ ++ p  + +  + + ++G+ ++k+  +   +
  EFC39174.1 117 ISEF----DYCGLLMYIWNIPFFRESFETKwNAISpnISENIKDpnivmnllILENleelISRIKSKsEFFP--MAL--SYTSSMGVRDFKY--N---N 202
                 4444....5588999999999999999977688874455666666666666544445556777777778888..444..44569***99999..4...5 PP

                 EEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS.-GGG....CCTT CS
     G-alpha 204 frivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg.klsk....yfps 297
                 + + +vgG+rs+rkkW+++f++ +  i lvsl+e dq+  ed ++ r++es  l  e++n+++l++++ i++++K+Dil +Kl+kg +++     + p+
  EFC39174.1 203 ILVKNVGGSRSQRKKWINCFNGQSLAILLVSLAELDQYTVEDARTLRMQESKMLLGELINSNFLRRARKIVIFTKPDILIKKLQKGhSINLgnfkMRPE 301
                 5588*******************************************************************************9999777653434477 PP

                 --..H.CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHHHH CS
     G-alpha 298 ye..grkndlesvlkylrnkFeeihkeksnnrrkiythftsatdtkevqkviesvrd 352
                 ++   +k++l++v++ + ++++++ +e  + ++    h++++t+ +ev++v+e++ d
  EFC39174.1 302 FKdiINKHELKKVVNSIVSHYLDFENEM-EFNKIHSFHIVNTTEMEEVNSVLERILD 357
                 776657999***************6554.333345567899************9976 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       1.4   5.1e+03      12      34 ..      26      48 ..      18      50 .. 0.75
   2 !   14.5   0.1   5.2e-06     0.019      50     128 ..     195     281 ..     176     299 .. 0.75
   3 !    4.6   0.1    0.0056        20     100     140 ..     298     338 ..     293     353 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.4
                TTEEEEEEEESTTSSHHHHHHHH CS
         Arf 12 kkelrilllGLDnaGKtTilkkl 34
                + e   ++lG   +G +T  +++
  EFC39174.1 26 STEDEWIILGTADSGTSTFYYMI 48
                45666789999999999998886 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 5.2e-06
                 EEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT..........THHHHHHHHHHHCTSGCCTTSEEEEEEE-TTST CS
         Arf  50 veeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre..........RleeakeeLkalleeeelkevallvlaNKqDlp 128
                 v++ +++n+   v  vGG ++ R+ W n f+     i +v  a+ +          R++e+k  L +l++++ l+++  +v+  K D+ 
  EFC39174.1 195 VRDFKYNNIL--VKNVGGSRSQRKKWINCFNGQSLAILLVSLAELDqytvedartlRMQESKMLLGELINSNFLRRARKIVIFTKPDIL 281
                 5555566554..558*************9998877776654332222222233344***********************9999999975 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.0056
                 HHHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHT CS
         Arf 100 akeeLkalleeeelkevallvlaNKqDlpealseeelrell 140
                 ++ e+k +++++elk+v+  +++   D ++ ++ +++++  
  EFC39174.1 298 MRPEFKDIINKHELKKVVNSIVSHYLDFENEMEFNKIHSFH 338
                 67899***************************999998754 PP

>> GDA1_CD39  GDA1/CD39 (nucleoside phosphatase) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0   0.00015      0.55     307     359 ..      38      90 ..      31     106 .. 0.79
   2 !    4.5   0.2    0.0031        11     247     302 ..     325     378 ..     282     394 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00015
   GDA1_CD39 307 lfgaseyfYtvsdvlklggekvklekltealrkfCkknweeikaeskkskeks 359
                 + g+s ++Y+++ +l + +++ + +++++ l+ +C+   + + +  ++s+ ++
  EFC39174.1  38 DSGTSTFYYMIERILRKNRNYSNRDEFNHDLQIVCSLMIKRLWTILEESERNR 90 
                 5689********************************66655555555555444 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0031
   GDA1_CD39 247 lektvevkdlefkqfaikgtgnyeqCrksikellnknak.CkaeeClfngvfapsid 302
                 +e+ +e+++  +++f+i +t++ e+ ++  +++l +n+k   +++Cl+ng  +p+ +
  EFC39174.1 325 FENEMEFNK--IHSFHIVNTTEMEEVNSVLERILDHNSKnTFISPCLLNGNRKPE-Q 378
                 233333333..679********************9966515578******99998.4 PP

>> ASXH  Asx homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   4.7e-05      0.17      31      91 ..      73     137 ..      65     145 .. 0.63
   2 ?   -2.0   0.0      0.92   3.3e+03      67      92 ..     242     269 ..     226     271 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 4.7e-05
        ASXH  31 sllnketwslLspeeqqeLlklLPeadr....iadseeedvdadsalrlsipal......ealrnnefFrs 91 
                 sl+ k+ w++L+++e+++++++ P+++     +  ++++++d+++     i+++        + n +fFr+
  EFC39174.1  73 SLMIKRLWTILEESERNRIIDMIPKSFGpcleN-LNDKSNIDDSQ-----ISEFdycgllMYIWNIPFFRE 137
                 788999*********************954321.11113333333.....333322222344555566665 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.92
        ASXH  67 vdadsalrlsipal..ealrnnefFrsa 92 
                 v++  +lr++ +++    l+n++f+r+a
  EFC39174.1 242 VEDARTLRMQESKMllGELINSNFLRRA 269
                 4445566776666667888999999887 PP

>> DUF1623  Protein of unknown function (DUF1623)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0    0.0016       5.8      33      62 ..     219     248 ..     215     263 .. 0.77
   2 ?    4.1   0.4     0.014        51      55      83 ..     324     356 ..     305     358 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0016
     DUF1623  33 vmclnGdcLAvvvssaniideldfdaakek 62 
                 + c nG +LA++++s   +d+  +++a++ 
  EFC39174.1 219 INCFNGQSLAILLVSLAELDQYTVEDARTL 248
                 78************9999999444444433 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.014
     DUF1623  55 df....daakekdlevldeyelkdvelLlekiy 83 
                 df    + +k ++ ++++++e+++v++ le+i 
  EFC39174.1 324 DFenemEFNKIHSFHIVNTTEMEEVNSVLERIL 356
                 3333337788999******************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (406 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       850  (0.0474092); expected 358.6 (0.02)
Passed bias filter:                      458  (0.0255452); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 2246.16
//
Query:       EFC39175.1  [L=320]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0049   16.1   2.2        0.1   11.8   2.2    2.2  1  Plavaka   Plavaka transposase


Domain annotation for each model (and alignments):
>> Plavaka  Plavaka transposase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   2.2   5.8e-06       0.1     209     274 ..     153     254 ..     122     318 .. 0.60

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.8e-06
     Plavaka 209 ghvrrvipilaayiaDypEqvlvacivqgwCpkctakkkelgdl.ee..............selrtreetlelleeaade................... 273
                 g   + +++ + +  D+pE++   + ++++C++c   +++l+++ ++              +++r+++e+++++e+ ++                    
  EFC39175.1 153 GEDIKLFICCMGFLLDTPERLKCLALMKNECSRCLDASDNLDKTpTDlmgasafnptcvhtFKRREHSEMKDIVEKLSELpkiadskqnriarkgvkeq 251
                 55556778888999***************************9953222233333333332236666666666665554324455555555555555555 PP

     Plavaka 274 ..l 274
                    
  EFC39175.1 252 twE 254
                 550 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1321  (0.0736795); expected 358.6 (0.02)
Passed bias filter:                      560  (0.0312343); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 1818.71
//
Query:       EFC39176.1  [L=111]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       269  (0.0150036); expected 358.6 (0.02)
Passed bias filter:                      183  (0.0102069); expected 358.6 (0.02)
Passed Vit filter:                         9  (0.00050198); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.49
# Mc/sec: 685.25
//
Query:       EFC39177.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.3e-07   29.9   0.0    9.2e-07   29.2   0.0    1.3  1  Thioredoxin_4  Thioredoxin


Domain annotation for each model (and alignments):
>> Thioredoxin_4  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.2   0.0   5.1e-11   9.2e-07      14     162 ..      62     235 ..      58     239 .. 0.72

  Alignments for each domain:
  == domain 1  score: 29.2 bits;  conditional E-value: 5.1e-11
                    SEEEEEEE-TT-HHHHHHHHHHHHHHHHHHHTT.....SEEEEEEE-..---STTTHHHHHHHTT--TT...HHHHHHHHHHHHTHHHHTTS-... CS
  Thioredoxin_4  14 pvtvieyedlrCphCakfeeeveklleeyidtG.....kvkfiirdfpldkekeslkaamaarcagees...peaflaikallysqqeewaes... 98 
                    +v +++y+dl+C+  a++ ++v+k l  y  +       +k+  + +pl+ + +s+  +m   + ++++    +  +++   +y++q+   ++   
     EFC39177.1  62 KVQIDLYVDLACSDSAEWWTSVFKSLDSYYFSNssssaPIKLNLHLLPLPYHISSYATSMSYIAINKYTnynSKVLKELINSFYTNQSPLYNNivs 157
                    7899*******************76666655444777789**********9986666666666655554121344444444467777777777765 PP

                    ............HHHHH.....HHHHHTS-------HHHHHHHHHHHHHHT--SS-EEEETTEEE..-TT--HHHHHH CS
  Thioredoxin_4  99 ............lkelaaealdkdekfeacleeekldalveaeskeakkagiestPtfiingekv..eepqtyeelka 162
                                +++++++ +    +  + + ++++d    +  k  +++g+ +tP+f++ng  +   e+ t++++ +
     EFC39177.1 158 emkqsemykliyTNNIQSLNVISWNDYLNLMLDGSIDMRTRTLFKLSTANGVFATPSFYVNGVAIqnGENFTFNDWVS 235
                    555445555555555666577776666667899***99999999999*****************94445677777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       902  (0.0503096); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.35s 00:00:00.96 Elapsed: 00:00:00.57
# Mc/sec: 1295.33
//
Query:       EFC39178.1  [L=595]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-05   25.5   0.0     0.0079   16.3   0.0    3.0  3  Nitroreductase  Nitroreductase family


Domain annotation for each model (and alignments):
>> Nitroreductase  Nitroreductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   4.4e-07    0.0079      28     157 ..      87     252 ..      71     258 .. 0.65
   2 ?   -3.2   0.1      0.42   7.5e+03       1      14 [.     380     393 ..     380     398 .. 0.83
   3 !    5.5   0.0   0.00088        16     105     146 ..     494     535 ..     474     553 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.4e-07
                     HTS--GGG---EEEEEE.-CCCH..........HHHHHHHHHHHHHHHTT-SS-GGGGGG.................................HH CS
  Nitroreductase  28 rraPsagnlqpwrfvvvqdkelr..........yklaeaalelllkaeaqaelaqryrke.................................el 79 
                     r  Ps+gnl+p++++++ + ++             +++ ++ ++  +                                              + 
      EFC39178.1  87 RVNPSSGNLHPCEVYLILNSNIQvdhlskndsnNTFNNNSNINNSNINN----------SnsninnsninnsnvndegtfiysyqpedhslqlRC 171
                     567**************65666643444443332222222222222222..........234553333334444445555555555556666544 PP

                     HHHHHHHHHHSSEEEEE..---TTS---HHHHHHHHHHHHHHHHHHHHHHHHHHHTT-EEEEE-GGGGGHHHHHHHH.T-S CS
  Nitroreductase  80 klkaqkalagapvlivi..vatldkserkaaerayryalldagaaaqnllLaAtalGlgscpiggfdeaaeevrkll.glp 157
                     ++ + ++l++ + +++i  ++   + ++k++ r+yry+ ld+g+ +  l ++ + lG+++++++     ++e+++ l gl+
      EFC39178.1 172 EFPNFSFLFNQQRYFFIciNTINYRETWKYGIRSYRYSQLDTGHLINCLKMSSNLLGWDCFMLNEHSSISNEFMEYLlGLD 252
                     444444444444444448899999**************************************9999877666666443766 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.42
                     HHH--B---B-S-- CS
  Nitroreductase   1 irkRrSiRkFddep 14 
                     ir+RrS   Fd + 
      EFC39178.1 380 IRTRRSAQSFDGKT 393
                     899*******9876 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.00088
                     -HHHHHHHHHHHHHHHHHHHHHHHHHHHTT-EEEEE-GGGGG CS
  Nitroreductase 105 rkaaerayryalldagaaaqnllLaAtalGlgscpiggfdea 146
                     + ++  +  y +++ag + q l+L+A+++Gl    ig f ++
      EFC39178.1 494 NIEHTHSFKYLYQEAGFIGQVLYLEAERIGLRGTGIGCFFDD 535
                     55677788999********************99999988755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (595 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       995  (0.0554967); expected 358.6 (0.02)
Passed bias filter:                      318  (0.0177366); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 3593.98
//
Query:       EFC39179.1  [L=653]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (653 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1021  (0.0569468); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.54
# Mc/sec: 3621.70
//
Query:       EFC39180.1  [L=173]
Description: hypothetical protein NAEGRDRAFT_59301 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.011   15.1   0.4      0.015   14.7   0.4    1.2  1  DUF1186   Protein of unknown function (DUF1186)
       0.39   10.8   9.9         15    5.7   9.9    2.3  1  Mod_r     Modifier of rudimentary (Mod(r)) protein


Domain annotation for each model (and alignments):
>> DUF1186  Protein of unknown function (DUF1186)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.4   1.6e-06     0.015     172     233 ..      85     146 ..      60     156 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.6e-06
     DUF1186 172 tsLvasscdlcpkeLkeeierafeedlvdsffiseedveeslelekdealkklkkkekyeli 233
                 +  v +  d + ke  ++i++ f ++ +d      e+v++ l++ +++ +++l+k+ + +l 
  EFC39180.1  85 KAPVEEFIDSYLKEKRKYIQQYFPDQNIDATSFTYEEVKQLLQVRDEQHFQELNKTVQEKLT 146
                 555778889999*****************************************999776664 PP

>> Mod_r  Modifier of rudimentary (Mod(r)) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   9.9    0.0017        15      46     102 ..     108     166 ..      45     167 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0017
       Mod_r  46 aeknlslep.eleelrselqekle.elkelekefeekeqeldellqkfspdallarLqt 102
                  ++n++    ++ee+++ lq + e +++el+k+++ek +e+ e + kf+ d + +++++
  EFC39180.1 108 PDQNIDATSfTYEEVKQLLQVRDEqHFQELNKTVQEKLTEQFEQFTKFNHDYISKQFKE 166
                 356666633599*******9999978***************************999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (173 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1743  (0.0972168); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.35s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 967.17
//
Query:       EFC39181.1  [L=425]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.9e-84  281.0   0.2    1.1e-83  280.7   0.2    1.1  1  Adap_comp_sub   Adaptor complexes medium subunit family
    5.4e-06   26.4   0.6    1.1e-05   25.4   0.3    1.7  2  Clat_adaptor_s  Clathrin adaptor complex small chain
     0.0027   17.7   0.4     0.0071   16.4   0.4    1.7  1  Longin          Regulated-SNARE-like domain


Domain annotation for each model (and alignments):
>> Adap_comp_sub  Adaptor complexes medium subunit family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  280.7   0.2   1.8e-87   1.1e-83       1     264 []     154     425 .]     154     425 .] 0.96

  Alignments for each domain:
  == domain 1  score: 280.7 bits;  conditional E-value: 1.8e-87
                    XXXXXXXXXXXX-EEEEEEEEEEEEEE-TTS-EEEEEEEEEEEEEE---TT-EEEEEE-SS-EE...........--S.SEESEEEEETT-B-TTH CS
  Adap_comp_sub   1 iswrrkgikykkneiyldviErvsvlvdkkGkilksevqGtiacksklsgmpelklgLndklnk...........ekk.ielddvsfHqcVnldkf 84 
                    +swr++gi y+kne++ldviE v++l+++kG++l+s+v+G+i +k+ lsgmpe+k+gLndkl++           + k i++dd++fHqcV+l kf
     EFC39181.1 154 VSWRKAGIVYRKNEVFLDVIEDVNMLLSNKGTVLSSDVTGRIVMKCLLSGMPECKFGLNDKLMLqqekrtankkrY-KeIDIDDITFHQCVKLGKF 248
                    69*********************************************************************97633.36***************** PP

                    HHH-EEEE---SEEEEEEEEEES--SS--SEEEEEEEEE-TTTSEEEEEEEEEE-S-TT-EEEEEEEEEE--TT-EEEEEEESSTT-EEEEETTEE CS
  Adap_comp_sub  85 eservisFiPpdgeftLmrYrlsannvklPfsvkpkvklsgdevrveielklkenfkkkltlenvkisiplpkevsnlaiktskGkakynpeenal 180
                    +s+r+isF+Ppdgef+LmrYr+ ++ + +Pf++ + +  + +++++e+++++k+ f  +l  +nv+++ip p+++ +++i +++Gkaky+ e+ a+
     EFC39181.1 249 DSDRTISFVPPDGEFELMRYRI-TDGIVPPFRLLSPIVRELSKTKLEVKVTIKSVFHARLFGKNVVVKIPCPSNTAKCKIHVAQGKAKYKAEKGAI 343
                    **********************.*********98888887888*************99************************************** PP

                    EEEE--EETT-EE..EEEEEEE--------------.EEEEEEEET--SS---EEEEEEE-------EEEEEEEEEEEEEEE-- CS
  Adap_comp_sub 181 eWtikklpggnesslsgeleleaesekkeenprdgklvsveFkipgftaSgikVeslkveeresykpfkwvryvtvsgeyeiri 264
                    +Wt+k++pg +e +ls+e+ l ++++ +++++++++ + + F++p+ftaSg++V++lkv e+++y+ +kwvry+t++g ye ri
     EFC39181.1 344 VWTVKRFPGDTELTLSAEVDLISQTA-ENKKWSRPP-IGLTFQVPMFTASGLHVRFLKVFEKSNYQAVKWVRYITQAGVYESRI 425
                    *********************99986.556666788.*******************************************9986 PP

>> Clat_adaptor_s  Clathrin adaptor complex small chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.4   0.3   1.9e-09   1.1e-05       1     135 [.       1     129 [.       1     136 [. 0.88
   2 ?   -3.0   0.0         1   6.1e+03      41      61 ..     145     165 ..     139     173 .. 0.75

  Alignments for each domain:
  == domain 1  score: 25.4 bits;  conditional E-value: 1.9e-09
                     -EEEEEEE-TTS-EEEEEES.SSS-CHHHHHHHHHHHHHHHTT-SSS-SEEEETTEEEEEEEETTEEEEEEEETTS-HHHHHHHHHHHHHHHHHH CS
  Clat_adaptor_s   1 mikaililnkkgkvrlakfy.tavddkkkqklieevyelvsaRdsklsniveledlkviYkryasLYFvvivdeqeneliilelihlfvesLdky 94 
                     mi a+liln +g++++ + y + v+   + ++++   + ++ R    + +  +  ++ ++ r  ++Y + + +++ +  +++e + +++  ++ y
      EFC39181.1   1 MISAVLILNSRGHTLISRAYrDDVETAFRSQILA---AKIADR----CPVKTIGSVTFMFIRHEEMYLLAVTKQNASAALVFEFLYKLIFIFQSY 88 
                     899*****************77777777777664...567778....99999999**************************************** PP

                     CT.S-SHHHHHHCHHHHHHHHHCCEETTEES---HHHHHHCH CS
  Clat_adaptor_s  95 fg.nVceldlvfnfekvylildEivsgGeiletskkevlkrv 135
                     f  +  e +l +nf+ vy +ldEi++ G  ++ +++ vlk++
      EFC39181.1  89 FDgKFTEDALKENFSLVYELLDEILDFGYPQNCEPQ-VLKNI 129
                     *989***********************998887764.55555 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1
                     TT-SSS-SEEEETTEEEEEEE CS
  Clat_adaptor_s  41 aRdsklsniveledlkviYkr 61 
                     +R ++++  v ++   ++Y++
      EFC39181.1 145 QRLKEVTGAVSWRKAGIVYRK 165
                     566666777888888888886 PP

>> Longin  Regulated-SNARE-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.4   1.2e-06    0.0071       5      71 ..      34      97 ..      30     106 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.2e-06
      Longin  5 lkkishsspqkltyt.hdsytfhylaedgltylviadesyprrlaFafLeeikreFlakygtaktada 71
                + ki    + ++ ++  +s tf ++ ++++  l +++++++  l F+fL ++   F++ ++++ t+da
  EFC39181.1 34 AAKI----ADRCPVKtIGSVTFMFIRHEEMYLLAVTKQNASAALVFEFLYKLIFIFQSYFDGKFTEDA 97
                4555....36888888889*************************************999998766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (425 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       679  (0.0378716); expected 358.6 (0.02)
Passed bias filter:                      563  (0.0314016); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 2804.70
//
Query:       EFC39182.1  [L=155]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (155 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1102  (0.0614647); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.49
# Mc/sec: 948.36
//
Query:       EFC39183.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       824  (0.0459591); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 2394.37
//
Query:       EFC39184.1  [L=432]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.9e-29  102.0   0.0    4.6e-29  101.3   0.0    1.2  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    7.7e-19   68.1   0.0    1.5e-18   67.1   0.0    1.5  1  GTP_EFTU_D3  Elongation factor Tu C-terminal domain
    1.6e-10   41.2   1.4      4e-10   39.9   1.4    1.7  1  GTP_EFTU_D2  Elongation factor Tu domain 2
    1.4e-05   24.6   0.0    2.9e-05   23.6   0.0    1.5  2  Gtr1_RagA    Gtr1/RagA G protein conserved region
    0.00022   21.3   0.3     0.0019   18.3   0.3    2.4  2  MMR_HSR1     50S ribosome-binding GTPase
     0.0012   18.7   0.6     0.0033   17.3   0.2    2.0  2  GTP_EFTU_D4  Elongation factor Tu domain 4
     0.0065   16.4   0.2      0.012   15.6   0.2    1.4  1  NTPase_1     NTPase
  ------ inclusion threshold ------
      0.015   15.4   0.0      0.032   14.4   0.0    1.5  1  AAA_33       AAA domain
       0.11   12.4   0.2        9.6    6.1   0.0    2.4  2  RsgA_GTPase  RsgA GTPase


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.3   0.0   2.3e-32   4.6e-29       2     189 ..       5     215 ..       4     220 .. 0.82

  Alignments for each domain:
  == domain 1  score: 101.3 bits;  conditional E-value: 2.3e-32
                 CEEEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH...HHHST............HCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHH CS
    GTP_EFTU   2 rirnigiighvDhGKtTLtdrLlyktgaiskkgeka...eeerv............lDtlkeErergiTiksaaisleketkkylinliDtPGHvdFsk 85 
                 +++n++++ghvD+GK+TL +rLl ++g+i++   ++   e+  +            l ++k+E + g Ti++a+   e  tk+y +n+iD+P   +F+k
  EFC39184.1   5 PTLNVVFVGHVDAGKSTLAGRLLNALGTINNGIIDRlrnES--TragmasflyanvLSRTKDEIKIGRTIQIAHSRAE--TKHYYLNIIDAP-VGSFMK 98 
                 679***************************97777675333..24589999****9**********************..************.568*** PP

                 HHHHHHHT-SEEEEEEETTTB.....STHHHHHHHHHHHHTTTEEEEEEESCGST.....HHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEB CS
    GTP_EFTU  86 evirglrvlDgavlvvdaveG.....vepqteevlrlalkegvpiivfiNKmDrl.....kaelkeiveevkqklsrkeeklekygekgekevpvvfgS 174
                   irg++++ +a++v+da+ G     +++  ++++   +   +++i+++NKmD       k+++ ei++e+ +         + +g+ +  e  ++++S
  EFC39184.1  99 SLIRGISQAGVAIIVLDAETGafeagIQSVRQTLIMTKSMGVIQLIFCVNKMDSRffnhsKDRFAEIKDEITRIA-------KRAGYIA--EPLFIPVS 188
                 *******************9866643555444555444444556*********9999999999999999999444.......4444444..356***** PP

                 TTTTBTHH............HHHHHHH CS
    GTP_EFTU 175 alkgegvk............tllealv 189
                 a++g+++             tll+a+ 
  EFC39184.1 189 AWNGWNILepadkfswfkgpTLLDAIN 215
                 *****9987777777777777888775 PP

>> GTP_EFTU_D3  Elongation factor Tu C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.1   0.0   7.7e-22   1.5e-18       3     111 ..     320     426 ..     318     427 .. 0.94

  Alignments for each domain:
  == domain 1  score: 67.1 bits;  conditional E-value: 7.7e-22
                  EEECCEEEEEEESSS..SS-BSTT-EEEEESSS-EEEEEEEEEEECCSSTTSB-BSS-SSCCSTT-CEEEEEEECCEEEE--TTTHCCCCEEEEECTT CS
  GTP_EFTU_D3   3 kphtkfeAqvyilekerhtpitagYrpvlyirtadvtgkvveLlskldkktekvsekkpefvkpGdnvivevelikpialekgseypqlGrFaiRegg 100
                  +++ +fe +++i++   ++ i   Y+p +++ t +  +k+++Ll++ +    +++e++p  +++G  ++v  e+ +p  +e ++ +p++GrF iR++g
   EFC39184.1 320 REVVSFEGEIVIVKC--PGVIKPSYKPTFHCYTLQTRCKFKQLLETSKMPDRSEKEENPTELRTGRFAVVLFEPDHPFYIEPFETFPPFGRFVIRDNG 415
                  67789**********..**************************88777666677789***************************************** PP

                  CEEEEEEEEEE CS
  GTP_EFTU_D3 101 rTvaaGvvtei 111
                  +   +G+v+++
   EFC39184.1 416 HVTCVGIVKKV 426
                  *********98 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.9   1.4     2e-13     4e-10       1      73 [.     242     311 ..     242     312 .. 0.90

  Alignments for each domain:
  == domain 1  score: 39.9 bits;  conditional E-value: 2e-13
                  EEEEEEEEEESEEETTEEEEEEC.TCTTSEE.EEEEEEEEEEETEEESEEETTSEEEEEEEESSCCSGSSTTCEE CS
  GTP_EFTU_D2   1 GtvalgrvysGtlkkGdevrilg.ndtskke.ivtrissletfhededeavaganaGvivaikgledaiivGdtl 73 
                  Gtv++g+++sGtlk + ++r+   ++    +   ++++s+e f++ ++ea ag+ + +++  +++ d +++G ++
   EFC39184.1 242 GTVVFGKIESGTLKLDTKLRFTNgKK----KiTDGTVGSIEIFRKSVTEAKAGEMVSIKLENVNYQD-LKAGIII 311
                  9********************44444....4466*********************************.9999766 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0       4.2   8.4e+03       2      15 ..       9      22 ..       9      24 .. 0.85
   2 !   23.6   0.0   1.4e-08   2.9e-05       9     148 ..      44     177 ..      42     192 .. 0.82

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 4.2
   Gtr1_RagA  2 vLLmGksgsGKtsm 15
                v+++G+  +GK+++
  EFC39184.1  9 VVFVGHVDAGKSTL 22
                67899******986 PP

  == domain 2  score: 23.6 bits;  conditional E-value: 1.4e-08
   Gtr1_RagA   9 gsGKtsmrsiiFdnylar..dtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesreleedletlkeileal 105
                 +s ++ m s +++n+l r  d +++g ti++ +s+   +++ +ln++D +   +f+++       +  ++ gv i V+D+e+  +e  +++ +++l   
  EFC39184.1  44 ESTRAGMASFLYANVLSRtkDEIKIGRTIQIAHSRA-ETKHYYLNIIDAP-VGSFMKSL-----IRGISQAGVAIIVLDAETGAFEAGIQSVRQTLIMT 135
                 577788********986433999************9.58999******99.56788875.....34568899***********************9888 PP

   Gtr1_RagA 106 rqyspeakvfvlihKmDliqedereeifeerkeeireeiekle 148
                 + +     +f+ ++KmD    ++ ++ f e+k+ei++ +++++
  EFC39184.1 136 KSMGVIQLIFC-VNKMDSRFFNHSKDRFAEIKDEITRIAKRAG 177
                 77776555665.8**********************99888655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.3   9.4e-07    0.0019       1     114 []       8     149 ..       8     149 .. 0.70
   2 ?   -2.3   0.0       2.2   4.4e+03      41      58 ..     323     339 ..     275     361 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 9.4e-07
                 EEEEEESTTSSHHHHHHHHHT...............................STEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltg...............................ekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgk 68 
                 +v++vG+  +GKStL  +l++                               ++ + + k g T++i + r ++k+  ++++D p           ++ 
  EFC39184.1   8 NVVFVGHVDAGKSTLAGRLLNalgtinngiidrlrnestragmasflyanvlSRTKDEIKIGRTIQIAHSRAETKHYYLNIIDAPV--G-----SFMKS 99 
                 599*****************76667777777777777777777777775433344444455999999999999888999****996..2.....22334 PP

                 HHHHHHCTSEEEEEEETT....TTCSHHHHHHHHHHHHHTTSEEEEEEES CS
    MMR_HSR1  69 aflaleeadlillvvdas....eeklkpldeeleelleeakkplilvlnk 114
                  ++ + +a ++++v+da+    e++++ ++++l  +++   ++li+++nk
  EFC39184.1 100 LIRGISQAGVAIIVLDAEtgafEAGIQSVRQTLIMTKSMGVIQLIFCVNK 149
                 44445569999999998866665567777777766654455556666665 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2.2
                 EEETTEEEEEEECGGCSS CS
    MMR_HSR1  41 vklkgkeielvDtpGlie 58 
                 v+++g ei++v +pG+i+
  EFC39184.1 323 VSFEG-EIVIVKCPGVIK 339
                 33333.577777777654 PP

>> GTP_EFTU_D4  Elongation factor Tu domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       6.9   1.4e+04      72      80 ..      64      73 ..      57      78 .. 0.58
   2 !   17.3   0.2   1.7e-06    0.0033       2      72 ..     227     299 ..     226     308 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 6.9
                 SS-.TTTS-- CS
  GTP_EFTU_D4 72 gki.vGrqik 80
                 ++i +Gr+i+
   EFC39184.1 64 DEIkIGRTIQ 73
                 4444555443 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 1.7e-06
                  -CEEEEEEEEEEETCCCEEEEEEEEEEEEETT-EEEETTE.E.E..EEEEEEEETTEEESEEETT-EEEEEEES CS
  GTP_EFTU_D4   2 PgkikilpgvvfrrsdpaivGvevlgGvikpgvklikedGre.v..GeilqiqdkgkkleeakaGqevaisieg 72 
                  P +i il+ +       ++ G ++ +G++k + kl  ++G++ +  G++ +i+  +k+++eakaG+ v+i +e+
   EFC39184.1 227 PLRIPILEVYNLEGVGTVVFG-KIESGTLKLDTKLRFTNGKKkItdGTVGSIEIFRKSVTEAKAGEMVSIKLEN 299
                  667777777777777889999.******************863467************************9986 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.2   5.8e-06     0.012       2     124 ..       9     138 ..       8     171 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 5.8e-06
                 EEEE--TTSSHHHHHHHHHHHH...GGGEEEEEEEEE-------E...EEEEET.T--EEEEEETT....---SSEETTEEE-HHH..HHHHHHHHHHH CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlellkssgvkvgGfyteevreggrrig...FkivdlasgeegiLarve....akreprvgkyvvdves..feelalealrk 91 
                 v+  G+   GK+Tl  ++l++l   g   +G++  + r++ +r g   F + ++ s +++++   +    a+++++ ++y++++ +  + +++ + +r 
  EFC39184.1   9 VVFVGHVDAGKSTLAGRLLNAL---GTINNGII-DRLRNESTRAGmasFLYANVLSRTKDEIKIGRtiqiAHSRAETKHYYLNIIDapVGSFMKSLIR- 102
                 56679999**************...99999987.6789999998755588888888888877666578899999********9877555555555554. PP

                 HHHHH-..EEEE-.--STTGGG-HHHHHHHHHHHTT CS
    NTPase_1  92 alsead..viviD.EiGkmElkskkfkeaveevLks 124
                  +s+a+  +iv+D E G +E  ++++++++  + + 
  EFC39184.1 103 GISQAGvaIIVLDaETGAFEAGIQSVRQTLIMTKSM 138
                 56777766899999*************998766663 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.0   1.6e-05     0.032       2      72 ..       9     110 ..       9     132 .. 0.60

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 1.6e-05
      AAA_33   2 vllvGlpGsGKstlaerllkklg......avllssdtlrrrlfg........tdqqskt....................dytrvldr.lyqilnelark 65 
                 v++vG+  +GKstla rll++lg        +l+  + r  ++         +    ++                    +y ++ d  +  +++ l+r 
  EFC39184.1   9 VVFVGHVDAGKSTLAGRLLNALGtinngiIDRLRNESTRAGMASflyanvlsR----TKdeikigrtiqiahsraetkhYYLNIIDApVGSFMKSLIRG 103
                 79*********************999988888998886666665544322110....111122222222222222222244443333244555555555 PP

      AAA_33  66 alsagrn 72 
                   +ag +
  EFC39184.1 104 ISQAGVA 110
                 5555555 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0    0.0048       9.6     102     123 ..       9      30 ..       4      49 .. 0.83
   2 ?    3.9   0.0     0.023        45      18      60 ..     109     154 ..      58     182 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0048
                  EEEECSTTSSHHHHHHHHCTT- CS
  RsgA_GTPase 102 svlvGqSGvGKStLinallpel 123
                  +v+vG+  +GKStL  +ll+ l
   EFC39184.1   9 VVFVGHVDAGKSTLAGRLLNAL 30 
                  79************99998764 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.023
                  EEEEEEESTTTT--H..HHHHHHHHHHHHTT-.EEEEEEE-GGG-- CS
  RsgA_GTPase  18 qllivvslkepelsl..nlldrfLvlaeekgi.epvivlnKiDlle 60 
                   ++iv+ +++  ++   + + + L++ ++ g+ +++ ++nK+D   
   EFC39184.1 109 VAIIVLDAETGAFEAgiQSVRQTLIMTKSMGViQLIFCVNKMDSRF 154
                  56677777776666422678999999999987699999***99754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2487.21
//
Query:       EFC39185.1  [L=520]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00031   20.8   0.4     0.0012   18.9   0.0    2.2  2  Erf4      Golgin subfamily A member 7/ERF4 family


Domain annotation for each model (and alignments):
>> Erf4  Golgin subfamily A member 7/ERF4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1      0.33     6e+03      19      39 ..     161     181 ..     152     190 .. 0.56
   2 !   18.9   0.0   6.7e-08    0.0012      15      96 ..     400     480 ..     365     502 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.33
        Erf4  19 tllppeLsgyiseeefeeiin 39 
                 ++l+++ ++ + +++f +ii+
  EFC39185.1 161 KSLVNNNNNNLMKTTFSNIID 181
                 444444444455555555554 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 6.7e-08
        Erf4  15 pqFstllppeLsgyiseeefeeiinkiNeilaeafspysvrnildnvlglltlylwslvlkthykkklkklekyieelNeel 96 
                  +++t + + L+++i  ++f + +n +N++l++++   +++ +l +++ ++tl+l+ l + ++  +    + ky++elN++ 
  EFC39185.1 400 LKYETNYHEFLEEAIPHKTFVTEMNLLNQFLKSNEPG-TKYCCLGFTFFCCTLGLSMLPFAYQLSHFETVVRKYLDELNKKY 480
                 57999999***********************999886.***********************9999988999********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (520 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2270  (0.126611); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.53
# Mc/sec: 2978.12
//
Query:       EFC39186.1  [L=350]
Description: guanine nucleotide-binding protein alpha-1 subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
   7.4e-100  334.5  13.7   9.1e-100  334.3  13.7    1.0  1  G-alpha    G-protein alpha subunit
    8.4e-11   41.6   3.5    4.2e-08   32.9   0.5    2.6  2  Arf        ADP-ribosylation factor family
    6.2e-05   22.5   3.8       0.11   11.8   1.2    2.4  2  Gtr1_RagA  Gtr1/RagA G protein conserved region
    0.00014   21.9   0.1      0.073   13.2   0.0    2.5  2  MMR_HSR1   50S ribosome-binding GTPase
     0.0024   18.1   2.5       0.62   10.3   0.0    2.9  3  Roc        Ras of Complex, Roc, domain of DAPkinase
     0.0052   17.3   0.3     0.0097   16.4   0.3    1.8  1  ABC_tran   ABC transporter
  ------ inclusion threshold ------
      0.018   14.5   0.3      0.039   13.4   0.1    1.8  2  Nop        snoRNA binding domain, fibrillarin
      0.043   13.6   0.1      0.085   12.6   0.1    1.5  1  AAA_29     P-loop containing region of AAA domain


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  334.3  13.7    4e-103  9.1e-100      19     353 ..      15     336 ..       6     338 .. 0.93

  Alignments for each domain:
  == domain 1  score: 334.3 bits;  conditional E-value: 4e-103
                 XE..EE......EEEEEESTTSSHHHHHHHHHHHCS----HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH.. CS
     G-alpha  19 kkkrev......kllllGqseSGKsTilkqlkllykkgfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliak 111
                 kk+++v      k+lllG+++SGKsTi+kql+++y++gf eee+   +++i++n++r++ ++++a  ++++++    ++++++er+ ++ +++++    
  EFC39186.1  15 KKSSHVvktppkKILLLGAGDSGKSTIFKQLQRIYNNGFPEEERILKKNIIYENVLRNMMSLIKATHTFQIPI----QNEDNRERALKIDQLSSKVLL- 108
                 2222223444459*****************************99889**************************....9***********999999654. PP

                 ........HHCCHHC-HCHHHHHHHHCCSHHHHHHHCCGCCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEEEEEE- CS
     G-alpha 112 lssateeeqeiefnpraevgedikaLwndpgiqelyerrnkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdsklefrivdvg 210
                        + e ++++  e+g++ikaLw+dpg+qe++++++++++ed+a+y++d+l+ri+++dY+pt++Di++ar+kt+G +e kf  + +++f ++dvg
  EFC39186.1 109 -------SIERVWSS--ELGQEIKALWEDPGVQETFKKKSSFQIEDSAQYYFDNLDRICQNDYIPTEEDIVRARMKTTGLIEQKFHSH-ETDFVMIDVG 197
                 .......28899999..********************************************************************998.********** PP

                 SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS.-GGGCCTT--H.CCHHHHH CS
     G-alpha 211 GqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkg.klskyfpsyegrkndlesv 308
                 Gqr+erkkW+++f++vd+++F++s+sefdq +yed+++nr++esl+lF++ +n++++  ++++L++nK+D++e+K+++g kls+ f+ y+g ++d+  +
  EFC39186.1 198 GQRNERKKWIHHFEGVDVVLFVTSMSEFDQKCYEDDQTNRMKESLQLFEDHINSRWFTGAQVYLLFNKYDLFEQKINTGvKLSDTFETYSG-EKDVTLA 295
                 ******************************************************************************************9.99***** PP

                 HHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHHHHH CS
     G-alpha 309 lkylrnkFeeihkeksnnrrkiythftsatdtkevqkviesvrdt 353
                  ++++n F++       n++ + +++++a+d +e+ k i+s+ ++
  EFC39186.1 296 RNFIINMFTSK----DINSKLVNVSCVTALDITELGKQIDSIVKS 336
                 *********98....4788899**************999988665 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.1   0.00043      0.97      15      35 ..      26      46 ..      13      54 .. 0.87
   2 !   32.9   0.5   1.9e-11   4.2e-08      42     144 ..     173     285 ..     165     316 .. 0.77

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00043
                EEEEEEESTTSSHHHHHHHHH CS
         Arf 15 lrilllGLDnaGKtTilkklk 35
                 +illlG   +GK+Ti k+l+
  EFC39186.1 26 KKILLLGAGDSGKSTIFKQLQ 46
                69*****************98 PP

  == domain 2  score: 32.9 bits;  conditional E-value: 1.9e-11
                 CSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CT..........THHHHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTS CS
         Arf  42 tvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadre..........RleeakeeLkalleeeelkevallvlaNKqDlpea 130
                  + T+g   ++ + ++ +f + DvGGq++ R+ W + fe +d+v+fv   ++ +          R++e+ + ++  ++++    +++ +l NK Dl e+
  EFC39186.1 173 RMKTTGLIEQKFHSHETDFVMIDVGGQRNERKKWIHHFEGVDVVLFVTSMSEFDqkcyeddqtnRMKESLQLFEDHINSRWFTGAQVYLLFNKYDLFEQ 271
                 56788888899999*********************************87653222222223334999999999999********************988 PP

                 S-HHHHHHHTTGGG CS
         Arf 131 lseeelrellglee 144
                   ++ ++ + + e+
  EFC39186.1 272 KINTGVKLSDTFET 285
                 77766665555444 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.1   7.2e-05      0.16       1      46 [.      27      75 ..      27     147 .. 0.82
   2 !   11.8   1.2   4.9e-05      0.11      41     133 ..     183     278 ..     154     337 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 7.2e-05
   Gtr1_RagA  1 kvLLmGksgsGKtsmrs...iiFdnylardtlrlgatidveksevrflg 46
                k+LL+G + sGK+++ +    i++n  +++ + l+  i  e+   ++++
  EFC39186.1 27 KILLLGAGDSGKSTIFKqlqRIYNNGFPEEERILKKNIIYENVLRNMMS 75
                89*************7633379**********99999966655544444 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 4.9e-05
   Gtr1_RagA  41 evrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDve...........sreleedletlkeilealrqyspeakvfvlihKmDliqede 128
                 ++  +++ ++ ++D+gGq++  ++       + f+ v+v+++V  ++           ++ ++e+l+ +++ ++  ++    a+v  l +K Dl +++ 
  EFC39186.1 183 KF-HSHETDFVMIDVGGQRNERKKW-----IHHFEGVDVVLFVTSMSefdqkcyeddqTNRMKESLQLFEDHIN--SRWFTGAQVYLLFNKYDLFEQKI 273
                 33.255678999******9988875.....688**********9888777667765433346666666666555..366789************99887 PP

   Gtr1_RagA 129 reeif 133
                 ++ + 
  EFC39186.1 274 NTGVK 278
                 76655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.3   0.0    0.0044       9.8       1      20 [.      27      46 ..      27      66 .. 0.87
   2 !   13.2   0.0   3.3e-05     0.073      25      99 ..     169     237 ..     155     265 .. 0.63

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0044
                EEEEEESTTSSHHHHHHHHH CS
    MMR_HSR1  1 evaivGrpNvGKStLinalt 20
                +++++G   +GKSt++++l 
  EFC39186.1 27 KILLLGAGDSGKSTIFKQLQ 46
                5899************9985 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.3e-05
                 EESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT........TTCSHHHHHHHHH CS
    MMR_HSR1  25 ivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas........eeklkpldeelee 99 
                 iv ++  tT  i+++ ++ ++++++++D+ G        ++++k++  + e +d++l+v ++s        +        + ++
  EFC39186.1 169 IVRARMKTTGLIEQK-FHSHETDFVMIDVGG-Q------RNERKKWIHHFEgVDVVLFVTSMSefdqkcyeD-------DQTNR 237
                 566666666666555.5556799********.3......46777777777779*******988665333221.......22222 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.0   0.00028      0.62       1      21 [.      27      47 ..      27      85 .. 0.77
   2 ?   -3.0   0.0       3.5   7.9e+03      59      77 ..     124     143 ..      90     150 .. 0.57
   3 !    6.9   0.3    0.0031         7      17      94 ..     155     227 ..     153     268 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00028
                EEEEESSTTSSHHHHHHCHCT CS
         Roc  1 KvvlvGdsgvGKtsllkrfve 21
                K++l+G + +GK++++k++++
  EFC39186.1 27 KILLLGAGDSGKSTIFKQLQR 47
                9**************998764 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 3.5
                 EEE.EE-SGGCTTTT-HHHH CS
         Roc  59 niW.DtaGqerfrslhplyl 77 
                 ++W D + qe f++  ++ +
  EFC39186.1 124 ALWeDPGVQETFKKKSSFQI 143
                 45523444666665555444 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0031
                 HCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHC CS
         Roc  17 krfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssen 94 
                 +r++++++ ++e+ ++ + ++t+ + +  +   + + ++  + + D++Gq + r+   +++++ +++++v+  +++++
  EFC39186.1 155 DRICQNDYIPTEEDIVRARMKTTGLIE--Q---KFHSHETDFVMIDVGGQRNERKKWIHHFEGVDVVLFVTSMSEFDQ 227
                 789999999999999999998887643..3...3334567899***********999999999999999987444322 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.3   4.3e-06    0.0097      12      80 ..      26     114 ..      19     288 .. 0.85

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 4.3e-06
                 SEEEEEESTTSSHHHHHHHHTTSS--...SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.....................H CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....................x RF
    ABC_tran  12 ekvaivGenGaGKStLlkllagllkp...teGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.....................e 80 
                 +k+ ++G   +GKSt++k l + +++   +e++i   +k++ +  +++lr+ ++ ++ +++++  +++++n                     +
  EFC39186.1  26 KKILLLGAGDSGKSTIFKQLQRIYNNgfpEEERI--LKKNIIY--ENVLRNMMSLIKATHTFQIPIQNEDNreralkidqlsskvllsiervW 114
                 68899*******************9887788888..4455555..689999999999999999888888888556655555444444444441 PP

>> Nop  snoRNA binding domain, fibrillarin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   1.7e-05     0.039       9      80 ..      38     122 ..      30     162 .. 0.71
   2 ?   -2.3   0.0       1.1   2.5e+03      85     120 ..     310     345 ..     288     347 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.7e-05
                 HHHHHHHHHHHHTTTSTCHHHHS-SHHHHHHHHHHCCC............CHCCT.HHTT...........HHHHHHHHHHHHCHHHH-SSS-S CS
         Nop   9 intlhkrvrewYswhFpELeslvkdnleYakvvklign............eredlekkee..........deelakevimaakvtastsmgael 80 
                  +t++k+++ +Y++ FpE e+++k+n+ Y +v + + +            +        +          d +l+++v++ ++   s++ g+e+
  EFC39186.1  38 KSTIFKQLQRIYNNGFPEEERILKKNIIYENVLRNMMSlikathtfqipiQ--------NednreralkiD-QLSSKVLLSIERVWSSELGQEI 122
                 57899************************9999888854433433333321........011122223222.2666666666655555555555 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.1
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHH CS
         Nop  85 lknikelcdrvleleelrkelleYlesrmsaiAPNl 120
                  k ++  c  +l+++el k++ + ++s ++ + P +
  EFC39186.1 310 SKLVNVSCVTALDITELGKQIDSIVKSIITRCNPQM 345
                 455666788888888888888888888887777766 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   3.8e-05     0.085      15      39 ..      19      42 ..      14      49 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 3.8e-05
      AAA_29 15 htieidlkgatlltGpsGsGKSTll 39
                h+++  +k  +ll G+  sGKST++
  EFC39186.1 19 HVVKTPPKK-ILLLGAGDSGKSTIF 42
                888888887.*************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       721  (0.0402142); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2095.98
//
Query:       EFC39187.1  [L=496]
Description: nucleoporin nup98 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.054   13.0   1.6      0.091   12.3   1.6    1.3  1  CLASP_N   CLASP N terminal


Domain annotation for each model (and alignments):
>> CLASP_N  CLASP N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   1.6   5.1e-06     0.091      11      94 ..     336     416 ..     328     420 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.1e-06
     CLASP_N  11 afegketelnwdaReknilklrslikgnvpedaveelleclkqlleailkalssLrttlsstgchllkelaiqlkeqldpmvei 94 
                   +gke e    ++e n + +   +k  v     +++l+++     +il+++ssL  tls + c++l +l i   + +  m++ 
  EFC39187.1 336 LVNGKELENRTAIKELNRQLFETQLKKSVTATELPHILSAIE---VWILHNFSSLNETLSYQICSVLDNLQINQIQTIVMMIQL 416
                 4578**************************************...*************************99988888877765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       805  (0.0448993); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 2854.28
//
Query:       EFC39188.1  [L=433]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (433 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       476  (0.0265492); expected 358.6 (0.02)
Passed bias filter:                      307  (0.0171231); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.27s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 2746.85
//
Query:       EFC39189.1  [L=1019]
Description: hypothetical protein NAEGRDRAFT_81341 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.23    9.6   0.0       0.35    9.0   0.0    1.2  1  HOOK      HOOK protein


Domain annotation for each model (and alignments):
>> HOOK  HOOK protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.0   1.9e-05      0.35      41      89 ..     735     783 ..     725     800 .. 0.91

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 1.9e-05
        HOOK  41 wFtesWlskikedvgdNwrLkvsNlkkilesvleYykevLnqqlsdell 89 
                  Ft+  l +i+++v +  +L  s l  i++ + + + +vL+q+++d+++
  EFC39189.1 735 LFTKDNLLNISTSVLARTKLTLSSLDTIVNIIHDHFDDVLEQKFKDYIT 783
                 69999999*************************************9864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1019 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       776  (0.0432818); expected 358.6 (0.02)
Passed bias filter:                      409  (0.0228122); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.78u 0.34s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 5756.48
//
Query:       EFC39190.1  [L=782]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (782 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       629  (0.0350828); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.30s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 4815.45
//
Query:       EFC39191.1  [L=1833]
Description: hypothetical protein NAEGRDRAFT_59307 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.1e-06   26.3   0.4         10    6.7   0.0    6.5  6  HEAT           HEAT repeat
    1.9e-05   25.1   0.7         15    6.2   0.0    6.6  7  HEAT_EZ        HEAT-like repeat
    0.00071   19.9   0.1         67    4.0   0.0    6.3  6  HEAT_2         HEAT repeats
     0.0056   17.3   0.6          1   10.0   0.0    5.1  6  Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
  ------ inclusion threshold ------
      0.031   13.7   3.9       0.17   11.3   0.1    3.7  4  RYDR_ITPR      RIH domain
       0.12   11.7   0.0       0.24   10.7   0.0    1.5  1  CcmH           Cytochrome C biogenesis protein
       0.14   12.2  11.3       0.77    9.8   0.4    5.3  5  Cnd1           non-SMC mitotic condensation complex subunit 1


Domain annotation for each model (and alignments):
>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0         7   1.8e+04       5      19 ..      49      63 ..      46      71 .. 0.74
   2 !    6.7   0.0    0.0039        10       5      28 ..     294     317 ..     290     320 .. 0.82
   3 ?   -1.9   0.0       2.2   5.7e+03       3      27 ..    1552    1577 ..    1551    1579 .. 0.82
   4 ?    3.7   0.0     0.035        91      12      31 .]    1645    1664 ..    1637    1664 .. 0.89
   5 ?    4.0   0.2     0.029        73       2      29 ..    1680    1707 ..    1680    1709 .. 0.92
   6 ?    3.0   0.0     0.061   1.6e+02       5      28 ..    1808    1831 ..    1806    1833 .] 0.85

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 7
                HHHHHT-SSHHHHHH CS
        HEAT  5 llkllsDpspeVRea 19
                ll +l D++ +V ++
  EFC39191.1 49 LLIALDDSDINVHKN 63
                566799*99999776 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0039
                 HHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   5 llkllsDpspeVReaAakaLgala 28 
                 ll++l+  +p++R aAa+++g ++
  EFC39191.1 294 LLEWLNLREPKIRLAAAQSIGYMC 317
                 566666679************998 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2.2
                  HHHHHHH.T-SSHHHHHHHHHHHHHH CS
        HEAT    3 Plllkll.sDpspeVReaAakaLgal 27  
                  ++ll+   +D+   V   A++ L  l
  EFC39191.1 1552 NALLSRSgTDEVVVVKLYALRGLSSL 1577
                  567777669************99887 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.035
                  SSHHHHHHHHHHHHHHHHCS CS
        HEAT   12 pspeVReaAakaLgalaevl 31  
                  ++p +Rea++k +gal +++
  EFC39191.1 1645 KDPLIREASIKLFGALHRFC 1664
                  699************97765 PP

  == domain 5  score: 4.0 bits;  conditional E-value: 0.029
                  HHHHHHHHT-SSHHHHHHHHHHHHHHHH CS
        HEAT    2 lPlllkllsDpspeVReaAakaLgalae 29  
                  lP+ll   +Dp+ +V  a+ +aL +l++
  EFC39191.1 1680 LPILLCHVQDPEENVSIACRLALRQLVP 1707
                  7999999******************997 PP

  == domain 6  score: 3.0 bits;  conditional E-value: 0.061
                  HHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT    5 llkllsDpspeVReaAakaLgala 28  
                  l  ll++psp +Re + k Lg l 
  EFC39191.1 1808 LTDLLKSPSPLIREKVSKMLGLLF 1831
                  56799***********99998775 PP

>> HEAT_EZ  HEAT-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       4.6   1.2e+04      33      55 .]     233     253 ..     223     253 .. 0.74
   2 ?    3.3   0.0     0.048   1.2e+02       2      37 ..     304     340 ..     303     348 .. 0.81
   3 !    6.2   0.0    0.0058        15       4      41 ..     438     475 ..     436     477 .. 0.92
   4 ?   -1.5   0.0       1.5   3.9e+03       2      24 ..     835     858 ..     834     865 .. 0.63
   5 !    5.9   0.0    0.0076        19       7      39 ..    1570    1602 ..    1566    1611 .. 0.87
   6 ?   -3.2   0.0       5.3   1.4e+04      40      55 .]    1645    1660 ..    1636    1660 .. 0.74
   7 ?   -0.5   0.0      0.75   1.9e+03      33      53 ..    1808    1828 ..    1806    1830 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4.6
     HEAT_EZ  33 LlalLnddsdeVRaaAagaLgnl 55 
                 Lla+   ++d+ R+  + aLg++
  EFC39191.1 233 LLAMI--KHDNLRWVFCAALGRW 253
                 44555..8888888889999987 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.048
     HEAT_EZ   2 rvRraAawaLGr.laggepellqplvpeilpaLlalL 37 
                  +R aAa  +G  +   e ++l++l+p+++p  ++ L
  EFC39191.1 304 KIRLAAAQSIGYmCHIIETDQLNQLLPKLMPNYIQSL 340
                 68999******98444468889999999999877666 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0058
     HEAT_EZ   4 RraAawaLGr.laggepellqplvpeilpaLlalLndds 41 
                 R +A+  L r l ++++e+l  + ++i+  L++ L+d+s
  EFC39191.1 438 RVSALKIL-RyLVVNNDEDLISYRDVIVSGLMKILKDPS 475
                 88999999.55************************9986 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 1.5
     HEAT_EZ   2 rvRraAawaLGr.laggepellqp 24 
                 ++R ++a++LG  + ++++  l +
  EFC39191.1 835 EERLGCARGLGQaAVNHCDSVLTQ 858
                 6899999****8555555444443 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.0076
     HEAT_EZ    7 AawaLGrlaggepellqplvpeilpaLlalLnd 39  
                  A+++L++l  + ++ l+++v+ ++ aLl+ L+d
  EFC39191.1 1570 ALRGLSSLSIHPKDILHQYVTPVIGALLSNLED 1602
                  8999999999******************99988 PP

  == domain 6  score: -3.2 bits;  conditional E-value: 5.3
     HEAT_EZ   40 dsdeVRaaAagaLgnl 55  
                  +++++R+a++  +g+l
  EFC39191.1 1645 KDPLIREASIKLFGAL 1660
                  45588**999999876 PP

  == domain 7  score: -0.5 bits;  conditional E-value: 0.75
     HEAT_EZ   33 LlalLnddsdeVRaaAagaLg 53  
                  L  lL+++s+++R+++   Lg
  EFC39191.1 1808 LTDLLKSPSPLIREKVSKMLG 1828
                  6779**********9988777 PP

>> HEAT_2  HEAT repeats
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.26   6.7e+02      30      61 ..      43      74 ..      36      86 .. 0.80
   2 ?   -2.4   0.0       2.5   6.5e+03      12      30 ..     238     256 ..     232     273 .. 0.75
   3 ?    4.0   0.0     0.026        67      35      59 ..     293     317 ..     277     348 .. 0.68
   4 ?   -1.7   0.0       1.6     4e+03      34      70 ..     823     862 ..     796     870 .. 0.58
   5 ?    1.8   0.0      0.13   3.2e+02       2      68 ..    1552    1631 ..    1551    1655 .. 0.74
   6 ?    3.3   0.0     0.043   1.1e+02      31      56 ..    1803    1828 ..    1778    1831 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.26
      HEAT_2 30 pealpaLvellededpavRraaaeaLgaigdp 61
                +++++ L+ +l+d+d +v +++ ++L +ig++
  EFC39191.1 43 DDIVKGLLIALDDSDINVHKNIHQSLLKIGNE 74
                57888899999999999999999999999986 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.5
      HEAT_2  12 pdpevrraairaLgrignp 30 
                 +++++r+  + aLgr+ + 
  EFC39191.1 238 KHDNLRWVFCAALGRWSEA 256
                 467899999****998764 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.026
      HEAT_2  35 aLvellededpavRraaaeaLgaig 59 
                 +L+e+l+  +p +R aaa+++g + 
  EFC39191.1 293 ILLEWLNLREPKIRLAAAQSIGYMC 317
                 5777777777888888888777442 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 1.6
      HEAT_2  34 paLvellededpavRraaaeaLgaigd...pealpaLkel 70 
                 + ++++ ++++ + R   a+ Lg+ +    +++l  L+  
  EFC39191.1 823 ERCFKITDHTSDEERLGCARGLGQAAVnhcDSVLTQLQNV 862
                 5555555555555555555555544321133344444443 PP

  == domain 5  score: 1.8 bits;  conditional E-value: 0.13
      HEAT_2    2 daLlqalendpdpevrraairaLg..rignpea........lpaLvellededpavRraaaeaLg...aigdpealpaLk 68  
                  +aLl++  +d+   v+  a+r L   +i+++++        + aL++ led + av  +a ++     +i++++ ++ L+
  EFC39191.1 1552 NALLSRSGTDEVVVVKLYALRGLSslSIHPKDIlhqyvtpvIGALLSNLEDLNQAVILEAMTSVKnifKIAEDAYISPLL 1631
                  56777776788888999999999987556664444445555889999999999999999999887333345555555554 PP

  == domain 6  score: 3.3 bits;  conditional E-value: 0.043
      HEAT_2   31 ealpaLvellededpavRraaaeaLg 56  
                   + + L++ll++++p +R+ + + Lg
  EFC39191.1 1803 HTTQGLTDLLKSPSPLIREKVSKMLG 1828
                  5577899**************99998 PP

>> Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.2   3.2e+03      24      54 ..      41      71 ..      35      86 .. 0.70
   2 ?   -1.8   0.0       1.9     5e+03      20      66 ..     282     328 ..     276     358 .. 0.78
   3 ?   -3.5   0.0       6.7   1.7e+04      66      85 ..     650     669 ..     644     674 .. 0.76
   4 ?   -1.7   0.0       1.8   4.6e+03      14      47 ..     841     874 ..     839     877 .. 0.88
   5 ?   -2.6   0.0       3.3   8.5e+03      16      41 ..    1261    1286 ..    1254    1288 .. 0.83
   6 !   10.0   0.0    0.0004         1       6      69 ..    1570    1634 ..    1566    1658 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.2
  Vac14_Fab1_bd 24 yleeivkpvlkcfsDkdsrvRyyacEslyni 54
                    +++ivk +l +++D+d  v      sl  i
     EFC39191.1 41 NIDDIVKGLLIALDDSDINVHKNIHQSLLKI 71
                   5677888888888888877766666666555 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.9
  Vac14_Fab1_bd  20 kikeyleeivkpvlkcfsDkdsrvRyyacEslyniakvakgevlkll 66 
                      +++l  + +++l+ ++ ++ ++R  a+ s+  ++ +++++ l++l
     EFC39191.1 282 YHSSVLTAMKHILLEWLNLREPKIRLAAAQSIGYMCHIIETDQLNQL 328
                    455666677778899999999999*9999999999998888877754 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 6.7
  Vac14_Fab1_bd  66 lneifdalvklvaDsdesvk 85 
                        f +l++ +aD  +  k
     EFC39191.1 650 YDIAFPVLCRAIADISKRKK 669
                    5667999*******987655 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 1.8
  Vac14_Fab1_bd  14 aialekkikeyleeivkpvlkcfsDkdsrvRyya 47 
                    a +l++++ ++++++++ + ++++  ++++ ++a
     EFC39191.1 841 ARGLGQAAVNHCDSVLTQLQNVMKAPEKKTGFFA 874
                    66899999999******************99998 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 3.3
  Vac14_Fab1_bd   16 alekkikeyleeivkpvlkcfsDkds 41  
                      le+++++y+++++k + + +s + +
     EFC39191.1 1261 ELEQEAANYVKKMIKLIPQFISNQRE 1286
                     5889999*******999888877766 PP

  == domain 6  score: 10.0 bits;  conditional E-value: 0.0004
  Vac14_Fab1_bd    6 gligLaavaialekkikeyleeivkpvlkcfsDkdsrvRyyacEslyniakvakgevlk.llnei 69  
                     +l gL +++i  +  +++y+  ++  +l+ ++D ++ v   a+ s+ ni k+a+++ ++ ll ++
     EFC39191.1 1570 ALRGLSSLSIHPKDILHQYVTPVIGALLSNLEDLNQAVILEAMTSVKNIFKIAEDAYISpLLMNL 1634
                     6889999***99999***************************************99887344444 PP

>> RYDR_ITPR  RIH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       2.5   6.5e+03     108     138 ..     419     454 ..     395     460 .. 0.66
   2 ?   -2.3   0.1      0.94   2.4e+03     119     171 ..    1053    1109 ..    1048    1122 .. 0.77
   3 ?   11.3   0.1   6.5e-05      0.17      79     145 ..    1461    1552 ..    1420    1565 .. 0.69
   4 ?    0.7   0.0      0.12     3e+02      79     121 ..    1753    1796 ..    1710    1810 .. 0.75

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 2.5
   RYDR_ITPR 108 h.lsylleqlarp....slregpLdvlaasLmdnne 138
                 + +s+l+ ql++p    ++r + L +l  ++++n e
  EFC39191.1 419 QvVSFLQAQLEQPtgttITRVSALKILRYLVVNNDE 454
                 336777777665511113444678888888888876 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.94
   RYDR_ITPR  119 pslregpLdvlaasLmdnneL.....vlkylseceiqsfiellrkgyegerfLdfLrs 171 
                  +s+ eg+ +vl ++L+  n       +lk l++++++s  +l r     + +  +L++
  EFC39191.1 1053 DSILEGVSNVLFSLLHTDNSQgtlddILKALETDHLNSQNSLERDRS-ANIYVSLLKD 1109
                  56667788999999986666558899999999999999988877766.6666666665 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 6.5e-05
   RYDR_ITPR   79 e......................yk.eivvlcyrlLayfcrdsrkNqeaiakhlsylleq..larpslregpLdvlaasLmdnneLvlkyls 145 
                  e                       k    +++ ++L  +c+ + +  +a+++ ++ ++++  +++  ++ ++  vl   +++ +eLv + ++
  EFC39191.1 1461 ErkeaiisstplefeatilegllQKkIYGDSVQEVLSKICKAYPQHVRAMFDFVKPFISRtfIGQRVIATCIISVLLNFIQNDRELVHNCIN 1552
                  13333344444444444444433122334567899***************************************************988876 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.12
   RYDR_ITPR   79 eykeivvlcyrlLayfcrdsrkNqeaiakh.lsylleqlarpsl 121 
                  e+ + ++ +   L +f ++ ++N+ a a   l+yll +l++++ 
  EFC39191.1 1753 EFPDRISDLVMNLVVFYKSEWSNCCASACLiLGYLLANLSKEQK 1796
                  45555566666788999999999999988889999999998875 PP

>> CcmH  Cytochrome C biogenesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   9.5e-05      0.24      49      82 ..     524     557 ..     521     560 .. 0.95

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 9.5e-05
                 --SHHHHHHHHHHHHHHHHT--HHHHHHHHHHHH CS
        CcmH  49 SnaelAkdlrrevremlkaGksdeeivdylvarY 82 
                 S+ ++A dl++++   l +G+++e++ + ++arY
  EFC39191.1 524 SERKIADDLKAKIPPSLLNGNDQEKVAQSMIARY 557
                 7889****************************** PP

>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.4    0.0003      0.77      58     132 ..      44     115 ..      37     135 .. 0.86
   2 ?   -2.4   0.0       1.6   4.2e+03      20      72 ..     418     476 ..     402     484 .. 0.69
   3 ?   -1.4   0.1      0.83   2.1e+03      91     141 ..    1223    1273 ..    1206    1301 .. 0.57
   4 ?    3.6   0.1     0.024        61      26      90 ..    1555    1623 ..    1542    1639 .. 0.77
   5 ?    1.1   0.1      0.14   3.6e+02      25      98 ..    1637    1719 ..    1627    1798 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.0003
        Cnd1  58 gflselaklleDenprVvanalaalteiseksenaiynllpdiisklsdalnecsewgqitilefLlsyipkdkq 132
                 ++++ l+ +l+D++ +V +n + +l +i ++ e   + ll+++++ l++   + ++++++ ++++L++  +k+ +
  EFC39191.1  44 DIVKGLLIALDDSDINVHKNIHQSLLKIGNECE---LLLLSKSLYFLNNTCPKSNKKHRVFVMNILTELLNKKPS 115
                 467889999********************9963...5567889999999999****************9998876 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.6
        Cnd1  20 eylvepLrkrLkDed..pyVRktaaivvakL...ilndmvkekg.flselaklleDenp 72 
                 +++v+ L+++L+ +      R  a+ ++  L    ++d++  ++ ++s l k+l+D++ 
  EFC39191.1 418 DQVVSFLQAQLEQPTgtTITRVSALKILRYLvvnNDEDLISYRDvIVSGLMKILKDPSG 476
                 55666666666655411445777888888888444445888888888999999999873 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.83
        Cnd1   91 naiynllpdiisklsdalnecsewgqitilefLlsyipkd.kqeaeslvekl 141 
                  + ++nl  ++i  l+d  +    ++ + +l++L++   k+ +qea + v+k+
  EFC39191.1 1223 SHLMNLIDTLIDTLVD-PEVDGANSSCIVLSALIRLRGKElEQEAANYVKKM 1273
                  4566666666666663.33344555666666666666555233455544443 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.024
        Cnd1   26 LrkrLkDedpyVRktaaivvakL.ilnd.mvk..ekgflselaklleDenprVvanalaalteisekse 90  
                  L ++ +De   V+  a+ +++ L i+++ +    +  ++  l++ leD n+ V+  a ++ ++i + +e
  EFC39191.1 1555 LSRSGTDEVVVVKLYALRGLSSLsIHPKdILHqyVTPVIGALLSNLEDLNQAVILEAMTSVKNIFKIAE 1623
                  66777899999*************776623332244599**************9999999998887744 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.14
        Cnd1   25 pLrkrLkDedpyVRktaaivvakL......ilndmvkekg..flselaklleDenprVvanalaalteisek.senaiynllp 98  
                  +L+ +++ +dp +R+  + ++  L      + +d+ ++     l  l+  ++D++++V+  +++al ++    +++a+ ++++
  EFC39191.1 1637 RLKPSFEKKDPLIREASIKLFGALhrfcdgVMRDTLISTIfnNLPILLCHVQDPEENVSIACRLALRQLVPTlKSEAFTEIFQ 1719
                  5566666677777777777777776655554444333222125556666779*************999987755555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1833 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      526  (0.0293379); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.13u 0.35s 00:00:01.48 Elapsed: 00:00:00.56
# Mc/sec: 9836.98
//
Query:       EFC39192.1  [L=311]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.7e-50  169.0   0.1      1e-49  168.4   0.1    1.3  1  IF4E        Eukaryotic initiation factor 4E
  ------ inclusion threshold ------
       0.27    9.9   3.6       0.29    9.8   3.6    1.1  1  Ndc1_Nup    Nucleoporin protein Ndc1-Nup
       0.38    9.3   6.7       0.34    9.4   6.7    1.2  1  Macoilin    Macoilin family
        3.5    7.3  17.0         60    3.3  17.0    2.0  1  SAGA-Tad1   Transcriptional regulator of RNA polII, SAGA, sub
        4.3    5.2  15.4        6.3    4.6  15.4    1.2  1  Dicty_REP   Dictyostelium (Slime Mold) REP protein


Domain annotation for each model (and alignments):
>> IF4E  Eukaryotic initiation factor 4E
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.4   0.1   2.9e-53     1e-49       1     159 []     113     267 ..     113     267 .. 0.96

  Alignments for each domain:
  == domain 1  score: 168.4 bits;  conditional E-value: 2.9e-53
                 EEEEEEEEEEE-TTT--SS-SGGG-EEEEEEEEHHHHHHHHHHS--GGGB-SSEEEEEEETT--SSTTSHHHHS-EEEEEEE-----HHHHHHHHHHHH CS
        IF4E   1 pLkskWtlwfdsksksksenyeeslkkvatfstveeFwslynnlkkpsklkvksdyhlFkkgikPmWEdpankkGGkwvirlkkkekldrlWeelllal 99 
                 pL +++t+ +  +++ k  +ye+ +k+v++fstve+Fw+ly+++k+p +lkv+ dyhlFk+gikPmWEd++nk+GG++++r+k+ +   r+We+llla+
  EFC39192.1 113 PLGDTFTFSY-FRKE-KGIDYEDCMKNVGDFSTVEQFWALYTHMKRPYELKVSMDYHLFKQGIKPMWEDDKNKTGGRLMLRCKS-GYSARIWEDLLLAF 208
                 6788999988.5666.79****************************************************************99.99************ PP

                 HTT-SS--.-SEEEEEEEE-SSEEEEEEEES-TT-HHHHHHHHHHHHHT--------EEE CS
        IF4E 100 igeqleeeedeicGvvvsvRkkedrisiWtrdasdeekvekigeklkevlelpeekkley 159
                 ig+q+++  ++++Gvv+s+R+++d+isiW+ d ++ee +e++++   ++l+lp+++kley
  EFC39192.1 209 IGQQFKNT-NDVNGVVISIRENHDIISIWNADGEKEEIQEALKQDAMKLLNLPSQTKLEY 267
                 *****999.************************************************998 PP

>> Ndc1_Nup  Nucleoporin protein Ndc1-Nup
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   3.6   8.2e-05      0.29     368     467 ..      20      99 ..       2     215 .. 0.55

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 8.2e-05
    Ndc1_Nup 368 nkasapvkelprlsksplkkkddeifgnsltaeaspkssssskegvekalsslakspgqspsptarlsprarkllekaksrllskeqkealsestikkk 466
                 ++++++ +++p                 ++t+++++++s++s +++++   + ++     ++pt + s  + ++++++ s +l  +q+  ++ s+ ++ 
  EFC39192.1  20 QQQQQSPTTTPA----------------TTTTTTTNSNSNTSGASISSNNINISSP----TNPTTSTSLNHSQTITNSPSVALGGNQQNNATTSNTSSA 98 
                 111111111111................1122222222222222222222222222....222222333333344444444444222222222222211 PP

    Ndc1_Nup 467 v 467
                  
  EFC39192.1  99 K 99 
                 1 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.7   9.6e-05      0.34     279     387 ..      16     106 ..       1     299 [. 0.57

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 9.6e-05
    Macoilin 279 vdsklqekeymenkskskrlsksessgsesellveesvkskssssssssnknskkasagsagssnssskkhsessksvtsssssknskkqklpaGkssa 377
                   +k+q+++  + +  ++  ++++s++++s      s++s++   ss +n++++++ ++s +++ns s  +                ++q+ ++  +++
  EFC39192.1  16 SGRKQQQQQSPTTTPATTTTTTTNSNSNTSGA----SISSNNINISSPTNPTTSTSLNHSQTITNSPSVALGG--------------NQQNNATTSNTS 96 
                 22222222222211111111111122222222....2222222222222233333333333333332222211..............111111222222 PP

    Macoilin 378 alkdaaensl 387
                 + k++++n+ 
  EFC39192.1  97 SAKKKTNNVE 106
                 2222222222 PP

>> SAGA-Tad1  Transcriptional regulator of RNA polII, SAGA, subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3  17.0     0.017        60      84     226 ..      30     311 .]       4     311 .] 0.72

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.017
   SAGA-Tad1  84 psatakkkks.................slkkspkksrsgdsqeerlkkrvmslpprdrkrlkaitkeagvlaee......................... 140
                 p++t+ ++++                 s++++p+ s s + ++  + +   +l+ ++++ + + +++      +                         
  EFC39192.1  30 PATTTTTTTNsnsntsgasissnniniSSPTNPTTSTSLNHSQTITNSPSVALGGNQQNNATTSNTS------Sakkktnnvetnekvhplgdtftfsy 122
                 2222222222445556666666666664455555555555554444444444444333333222222......02223445555666777777777777 PP

   SAGA-Tad1 141 ................................................................................................... 140
                                                                                                                    
  EFC39192.1 123 frkekgidyedcmknvgdfstveqfwalythmkrpyelkvsmdyhlfkqgikpmweddknktggrlmlrcksgysariwedlllafigqqfkntndvng 221
                 7888888999999999999999999999999******************************************************************** PP

   SAGA-Tad1 141 .....sskpkisvvseeetekrekennskewsqeirspvaaPLgsesgelpdtdsLrk..RmekiaeeeGLvggvsadcaellnlaldvyLKn 226
                       + ++i ++ + ++ek+e ++  k   q+ ++ ++ P  ++    p+ +s+ +  +m ++   +  ++g ++d++  l + l+vyLK+
  EFC39192.1 222 vvisiRENHDIISIWNADGEKEEIQEALK---QDAMKLLNLPSQTKLEYKPHQESINNhtKMLEMIGNNATSQGFDEDAVTELDQELEVYLKR 311
                 **988555555555666666666555555...9*********99999999******75449*******************************6 PP

>> Dicty_REP  Dictyostelium (Slime Mold) REP protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6  15.4    0.0017       6.3     239     328 ..      10     109 ..       2     135 .. 0.63

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0017
   Dicty_REP 239 sentqrensqpskeknkttttttttttttsqartrkrkaidddklsenqakekkknskksdddp..........qsdfskkssrksgslkdvrvdnisd 327
                  +n+ r  +++++++++ttt  ttttttt+ +  +   +i+ ++++ +   +++ +++ +++++          +++ ++ ++ +  s k+  +++ ++
  EFC39192.1  10 VQNKPRSGRKQQQQQSPTTTPATTTTTTTNSNSNTSGASISSNNINISSPTNPTTSTSLNHSQTitnspsvalgGNQQNNATTSNTSSAKKKTNNVETN 108
                 467778888888888888888888888888887777777777777664433333333333334455888999974444444444444444444444443 PP

   Dicty_REP 328 s 328
                 +
  EFC39192.1 109 E 109
                 3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1822  (0.101623); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.48
# Mc/sec: 1954.95
//
Query:       EFC39193.1  [L=629]
Description: hypothetical protein NAEGRDRAFT_81347 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.029   14.8   3.0      0.029   14.8   3.0    2.9  2  Snapin_Pallidin  Snapin/Pallidin
       0.12   12.8   2.5         17    5.9   0.1    3.8  4  MtrB             Tetrahydromethanopterin S-methyltransferase 
       0.18   11.7   1.0       0.29   11.1   0.1    1.8  2  MORN             MORN repeat
       0.36   11.2   9.7       0.48   10.7   2.2    2.8  3  DUF4164          Domain of unknown function (DUF4164)
       0.39   11.4   8.6        1.4    9.7   8.6    2.0  1  Cytochrom_B562   Cytochrome b562
       0.75    9.6  15.5        1.9    8.3  15.5    1.6  1  Apolipoprotein   Apolipoprotein A1/A4/E domain
       0.84    9.7  12.7       0.97    9.5   5.7    2.7  2  DUF1664          Protein of unknown function (DUF1664)


Domain annotation for each model (and alignments):
>> Snapin_Pallidin  Snapin/Pallidin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   3.0   1.1e-05     0.029       5      62 ..     203     259 ..     202     265 .. 0.89
   2 ?   -0.7   2.8      0.76   1.9e+03      48      69 ..     295     317 ..     267     360 .. 0.59

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.1e-05
  Snapin_Pallidin   5 egllellepkldeldeklkelrqsQeeLleqldrlnekLkeleeaqeaevlpdlkeya 62 
                      +gll  ++ kl++++ek+k+l+++   L +ql + +e+L+ +++ +  e+ ++l++y+
       EFC39193.1 203 SGLLHAWKEKLNNVQEKIKNLTKQKANLESQLAEVTEELTYFRNKDT-ETEQRLEQYI 259
                      69*************************************97777666.6778888876 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.76
  Snapin_Pallidin  48 eaqeaevlpdlkeya.kKLvnik 69 
                       a++++ +++l++ + +K+ n+ 
       EFC39193.1 295 IAKKNSEMEELRQSLhNKIENLD 317
                      22222222222222113443333 PP

>> MtrB  Tetrahydromethanopterin S-methyltransferase subunit B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.9   4.9e+03      39      57 ..     141     159 ..     122     162 .. 0.74
   2 ?    5.9   0.1    0.0066        17      14      67 ..     201     249 ..     194     253 .. 0.85
   3 ?    0.4   0.1      0.34   8.8e+02       6      53 ..     267     314 ..     264     334 .. 0.81
   4 ?    3.1   0.0     0.048   1.2e+02      43      69 ..     338     364 ..     324     368 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.9
        MtrB  39 dkLekiaddlvnsLdpeta 57 
                   L++i+  + nsL+p+++
  EFC39193.1 141 GSLDAISPRVNNSLTPNSS 159
                 57999999999****9875 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0066
        MtrB  14 petgvvaearedvvllsldpvleeidkLekiaddlvnsLdpetallesypgRek 67 
                  ++g++ +++e     +l++v+e+i++L k   +l+++L+  t+ l  + +++ 
  EFC39193.1 201 KQSGLLHAWKE-----KLNNVQEKIKNLTKQKANLESQLAEVTEELTYFRNKDT 249
                 56677777777.....899*********************99999999988775 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.34
        MtrB   6 pelnlvldpetgvvaearedvvllsldpvleeidkLekiaddlvnsLd 53 
                  e++lv + +   ++++ +++  ++ +++ ++  ++e++ + l n+++
  EFC39193.1 267 EEYELVTNKKIKTLESTIHEINQVKEMEIAKKNSEMEELRQSLHNKIE 314
                 689999999999999999999999999999999999999999988876 PP

  == domain 4  score: 3.1 bits;  conditional E-value: 0.048
        MtrB  43 kiaddlvnsLdpetallesypgRektl 69 
                 +++d+  +sL+pet+ +++ p+R +++
  EFC39193.1 338 AAVDESPTSLSPETNQISAIPKRRSSI 364
                 67899999**************98765 PP

>> MORN  MORN repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       4.8   1.2e+04      11      16 ..       2       7 ..       1      10 [. 0.76
   2 ?   11.1   0.1   0.00011      0.29       2      16 ..      20      34 ..      20      36 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.8
        MORN 11 hGkGvy 16
                 G G+y
  EFC39193.1  2 TGRGHY 7 
                699999 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 0.00011
        MORN  2 eGeWknGkrhGkGvy 16
                +Ge+ nG  hG G++
  EFC39193.1 20 SGEFLNGVLHGRGTC 34
                5************98 PP

>> DUF4164  Domain of unknown function (DUF4164)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   2.2   0.00019      0.48      32      82 ..     211     261 ..     200     268 .. 0.90
   2 ?    3.0   1.2     0.047   1.2e+02       3      64 ..     299     329 ..     260     339 .. 0.53
   3 ?    3.8   0.3     0.027        68       3      44 ..     299     340 ..     297     350 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00019
     DUF4164  32 rkrdeleaeiealgedrsRLaeeLdqaearaarleevnrEvsrrLkaaiet 82 
                 +k ++++++i+ l++ ++ L+ +L +++ ++++  +   E+ +rL+  i +
  EFC39193.1 211 EKLNNVQEKIKNLTKQKANLESQLAEVTEELTYFRNKDTETEQRLEQYISQ 261
                 667899***************************************998865 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.047
     DUF4164   3 tkeleaaltrLeaaldsLEkavdrrleaerkrdeleaeiealgedrsRLaeeLdqaearaar 64 
                 ++e+e+  + L++++++L++  +++ +                                +++
  EFC39193.1 299 NSEMEELRQSLHNKIENLDREWNQKYS-------------------------------DLEK 329
                 234444444444444444444444444...............................4443 PP

  == domain 3  score: 3.8 bits;  conditional E-value: 0.027
     DUF4164   3 tkeleaaltrLeaaldsLEkavdrrleaerkrdeleaeieal 44 
                 ++e+e+  + L++++++L++  +++ +  +k +  ++  +a+
  EFC39193.1 299 NSEMEELRQSLHNKIENLDREWNQKYSDLEKVKTTQQPTAAV 340
                 5789999****************9999999887777666555 PP

>> Cytochrom_B562  Cytochrome b562
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   8.6   0.00053       1.4      15     100 ..     227     312 ..     205     314 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00053
  Cytochrom_B562  15 qvakaddaeelkkalkelraaaedakeatpsklekdseeqkdYqeGldklidqldkaealakagkleeakaalkelkdlrkeyHkk 100
                     +++ +++ +e++++l+ +r+  ++ ++   + + + +e +++Y+   +k i++l+++  ++++ k  e+++  +e+++lr++ H+k
      EFC39193.1 227 KANLESQLAEVTEELTYFRNKDTETEQRLEQYISQHKELFEEYELVTNKKIKTLESTIHEINQVKEMEIAKKNSEMEELRQSLHNK 312
                     34455678899999999999999999988888888*************************************************98 PP

>> Apolipoprotein  Apolipoprotein A1/A4/E domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3  15.5   0.00074       1.9      45     182 ..     190     328 ..     186     335 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00074
                     HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCHHCCHHCHC...CHCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH CS
  Apolipoprotein  45 eleevrarlepyrdevqeqlgqnleelrqrlapyteelrerlaadaeelqeqla...vyaeelrerlerhvealkarlapyveelrqklaerlee 136
                     el+ v++ l ++ + + + ++++l +++++++++t++ ++ l+ ++ e+ e l+    +  e ++rle+ +++ k+ +++y   + +k++     
      EFC39193.1 190 ELNRVKNDLVEKQSGLLHAWKEKLNNVQEKIKNLTKQKAN-LESQLAEVTEELTyfrNKDTETEQRLEQYISQHKELFEEYELVTNKKIKTLEST 283
                     7889999999999999999999999999999999998755.455555555555400044555888888888888888888866666655555555 PP

                     HHH-----..---.--SSSHHHHHHHTS-TTSHHHHHS--XXXXXXX CS
  Apolipoprotein 137 lkeslaphaeeve.erlssrveelrekleeqaeelrerleanleelk 182
                     ++e   ++++e+e ++ +s++eelr++l  ++e+l ++ ++  ++l+
      EFC39193.1 284 IHEI--NQVKEMEiAKKNSEMEELRQSLHNKIENLDREWNQKYSDLE 328
                     5554..34456667899999999999999999999998888777776 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   5.7   0.00038      0.97      49     122 ..     212     289 ..     199     292 .. 0.84
   2 ?    3.6   0.7     0.025        64      53      82 ..     298     327 ..     290     359 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00038
     DUF1664  49 qleqvs...eslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesv.keavegleskleriee 122
                 +l++v+   ++l+++k +L+s++++v ++l    +  +e+++ +++  ++ +e+ e+ e v ++ +++les++++i++
  EFC39193.1 212 KLNNVQekiKNLTKQKANLESQLAEVTEELTYFRNKDTETEQRLEQYISQHKELFEEYELVtNKKIKTLESTIHEINQ 289
                 555555222667899***************************************99999993468*********9975 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.025
     DUF1664  53 vseslaatkrhLssridrvdkkldeqkeis 82 
                   +++++ ++ L ++i+++d++ ++     
  EFC39193.1 298 KNSEMEELRQSLHNKIENLDREWNQKYSDL 327
                 456677777788888888887776654322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (629 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3564  (0.198784); expected 358.6 (0.02)
Passed bias filter:                      560  (0.0312343); expected 358.6 (0.02)
Passed Vit filter:                       118  (0.00658152); expected 17.9 (0.001)
Passed Fwd filter:                        42  (0.00234257); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.20u 0.32s 00:00:01.52 Elapsed: 00:00:00.56
# Mc/sec: 3365.95
//
Query:       EFC39194.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.8e-06   26.5   0.4    0.00062   19.5   0.5    2.5  2  SAP       SAP domain


Domain annotation for each model (and alignments):
>> SAP  SAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.0    0.0019        35      11      24 ..     142     155 ..     140     156 .. 0.91
   2 !   19.5   0.5   3.5e-08   0.00062       9      31 ..     182     204 ..     174     204 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0019
                 HHHHHTT--TTS-H CS
         SAP  11 eeLkkrGLptsGkK 24 
                  ++k +G +t G+K
  EFC39194.1 142 NYCKNYGESTEGNK 155
                 68***********9 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 3.5e-08
                 HHHHHHHTT--TTS-HHHHHHHH CS
         SAP   9 LKeeLkkrGLptsGkKaeLieRL 31 
                 LKe + ++GL t GkKa Li+RL
  EFC39194.1 182 LKEMCLELGLNTEGKKALLIDRL 204
                 9*********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1303  (0.0726756); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 1999.31
//
Query:       EFC39195.1  [L=560]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.023   14.5   0.1      0.073   12.9   0.1    1.9  1  SAM_3     SAM domain (Sterile alpha motif)


Domain annotation for each model (and alignments):
>> SAM_3  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1     4e-06     0.073      12      56 ..      14      61 ..       5      70 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4e-06
       SAM_3 12 peeVkaWLtakgFskktvesLg..klsGaqLfsLske.eLeqicgaae 56
                 e+ + WL +k++ kk+++ L+  k +G  L++L++e +L++  ++  
  EFC39195.1 14 VEDFAYWLLQKNYKKKIIKVLKkeKWNGDSLMELKQEgDLQSKIPSGV 61
                578899***************73359********99757777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (560 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       876  (0.0488594); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 3216.57
//
Query:       EFC39196.1  [L=450]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.7e-67  226.9   0.1    6.2e-67  225.7   0.1    1.6  1  Thiolase_N      Thiolase, N-terminal domain
    1.7e-35  121.3   0.0      5e-35  119.8   0.0    1.8  2  Thiolase_C      Thiolase, C-terminal domain
    7.9e-05   22.3   0.1     0.0002   21.1   0.1    1.6  1  ketoacyl-synt   Beta-ketoacyl synthase, N-terminal domain
  ------ inclusion threshold ------
       0.18   11.1   0.0        0.3   10.3   0.0    1.3  1  FAE1_CUT1_RppA  FAE1/Type III polyketide synthase-like protei


Domain annotation for each model (and alignments):
>> Thiolase_N  Thiolase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  225.7   0.1   1.4e-70   6.2e-67       2     260 .]      22     296 ..      21     296 .. 0.93

  Alignments for each domain:
  == domain 1  score: 225.7 bits;  conditional E-value: 1.4e-70
                 EEEEEEEE--EETTSTTTTS-HHHHHHHHHHHHHHHHTS-GGGCCEEEEEHSSCTTSTSCHHHHHHHHTTS-TTSEEEEEEHGGGHHHHHHHHHHHHHH CS
  Thiolase_N   2 vivsaartpigkfggslkdlsaeeLlaealkallekagvdpeevdevivGnvlqagegqniarqaalkagipeevpavtvnkvcsSglkavalaaqsia 100
                 viv +artp++k  g l ++ +  L+ +a+++ll+k+++dp+ +de+i+Gnv+ + +  n+ar++++++++p++++ vtv ++c Sgl+a+ ++++ i 
  EFC39196.1  22 VIVCGARTPFVKAFGDLMEVDSIGLGVSAVEGLLKKTKLDPNLIDEIIWGNVVLNTKAPNVAREIVIDLNLPKKITGVTVSRACLSGLEAILQGIRLIE 120
                 8************************************************************************************************** PP

                 TTSHSEEEEEEEEESTTS-EEETCTTT...................TGGSSSSEEEEEHHHHH..HTEETTTTSEHHHHHHHHHHHHT--HHHHHHHHH CS
  Thiolase_N 101 ageadvvvagGvEsmsnaptaestdvr...................sglklgdekakdllipd..gladafneehmGltaenlakkykisReeqdefAv 178
                  g+advvvagG  smsn ++a ++++                    +   ++d+      ip+  ++a+ +++++mG +a+ +a+  ki+R+ qdefA 
  EFC39196.1 121 HGAADVVVAGGSDSMSNGEMALPRNLTlalgkysygkdkgsmkgliQ--FFKDAGSPLSWIPTapAIAERSTGKTMGYHADLMADLNKITRNVQDEFAT 217
                 ***********************9999*****999999866644322..22222222233444679********************************* PP

                 HHHHHHHHHHHTTTTTTTBE-EEEEESSSEEEE-S-TTS-TT--HHHHHTS-BSSSTTSS-BTTSB--BEEEEEEEEEEEHH CS
  Thiolase_N 179 kshqkaaaaqkagkFkdeivPvkvkgkkgkktvdkdeairsevtaekLaklkpaFkkeGtvtAgnasqisDGaaavllmses 260
                 +sh++aa+a  +gkF++ei Pv++k+ k   +v++d+ ir+++ + k+ klkp+F+k GtvtA+ +s+++DGa++vl+mse+
  EFC39196.1 218 ASHKNAAKARREGKFEEEISPVRLKNGK---IVNRDNLIREDSDVSKMGKLKPVFRKTGTVTAASSSPLTDGASCVLVMSEE 296
                 ************************9987...*************************************************96 PP

>> Thiolase_C  Thiolase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.2   5.2e+03       7      38 ..     166     197 ..     162     209 .. 0.76
   2 !  119.8   0.0   1.1e-38     5e-35       6     122 ..     308     442 ..     303     443 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.2
                 EEEEEEEE--GGGGGGHHHHHHHHHHHHHT-- CS
  Thiolase_C   7 irsyaevgvdpeilglgPayaikkvlkkaglt 38 
                 i+ ++ +g + + + ++Pa a +   k +g +
  EFC39196.1 166 IQFFKDAGSPLSWIPTAPAIAERSTGKTMGYH 197
                 66677888888999999999988877777765 PP

  == domain 2  score: 119.8 bits;  conditional E-value: 1.1e-38
                 EEEEEEEEE--G.GGGGGHHHHHHHHHHHHHT--GGGESEEEE--SBHHHHHHHHHHHT--G.................GGBSTT--HHHH-B-TTTHH CS
  Thiolase_C   6 kirsyaevgvdp.eilglgPayaikkvlkkagltvedidlfEinEAFaaqaLavakaldldl.................ekvNvnGGaialGHPlGasG 86 
                 +i+sya+++vdp  +l l+P+ a +kvl+ ag+t++++dlfEi+EAFaaq+L+++  l +d+                 ek+NvnG +i+lGHP+ a+G
  EFC39196.1 308 RISSYATTAVDPyPQLLLAPVLAFPKVLDGAGVTLDQVDLFEIHEAFAAQVLSTTACLASDEfcqkrlgkskalgvippEKLNVNGSSISLGHPFSATG 406
                 799*********99************************************************************************************* PP

                 HHHHHHHHHHHHHCTTSEEEEEEEETTTEEEEEEEE CS
  Thiolase_C  87 aRivvtllselkkeggklgvaalCigggqgvalvie 122
                  Ri++++++el+++++++++ ++C++gg g  +++e
  EFC39196.1 407 GRILTSAMNELRRSNKRYAILSVCAAGGLGGVALVE 442
                 ****************************99877776 PP

>> ketoacyl-synt  Beta-ketoacyl synthase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.1   4.4e-08    0.0002     169     207 ..      99     137 ..      92     151 .. 0.91

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 4.4e-08
                    EEEESGGGHHHHHHHHHHHHHHTTS-SEEEEEEEE---S CS
  ketoacyl-synt 169 vtvdtACsSslvavhaavqslrsgeadvalaGGvelllt 207
                    vtv+ AC S+l a+ + ++ + +g adv++aGG++ + +
     EFC39196.1  99 VTVSRACLSGLEAILQGIRLIEHGAADVVVAGGSDSMSN 137
                    78999******************************7754 PP

>> FAE1_CUT1_RppA  FAE1/Type III polyketide synthase-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   6.8e-05       0.3      88     147 ..      48     107 ..      37     130 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 6.8e-05
  FAE1_CUT1_RppA  88 fgavdellaktkvspkdidilv.vncslfsptPslsamvvnryklredvksynLsgmGCsA 147
                     ++av+ ll+ktk++p+ id ++  n+ l + +P ++  +v   +l + ++ + +s   C  
      EFC39196.1  48 VSAVEGLLKKTKLDPNLIDEIIwGNVVLNTKAPNVAREIVIDLNLPKKITGVTVSR-ACLS 107
                     579***************9666269999999****************999888775.4544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (450 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       334  (0.018629); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.28s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 2686.58
//
Query:       EFC39197.1  [L=254]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.6e-38  130.3   0.0    1.1e-37  129.8   0.0    1.2  1  Pro_isomerase  Cyclophilin type peptidyl-prolyl cis-trans iso


Domain annotation for each model (and alignments):
>> Pro_isomerase  Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  129.8   0.0   5.9e-42   1.1e-37      11     155 ..      98     239 ..      84     242 .. 0.90

  Alignments for each domain:
  == domain 1  score: 129.8 bits;  conditional E-value: 5.9e-42
  Pro_isomerase  11 rivieLfadkaPktvenFlklvkeg...fYdgttFhRvikgfmvqgGdptgktsageqe.kkggesiraipdEitsklkhkrGalamartgkepns 102
                    riv+ Lf+++ PktvenF+ lv+ +    Y+g+ +hR+++gf++qgGd+t+++   ++  +  g   + ++dE+  ++   +G lama++g  pns
     EFC39197.1  98 RIVLGLFGNEQPKTVENFRSLVTHErqiGYRGSLLHRIVRGFVLQGGDITKGDG--TGGvSIYG---QSFDDEN-LSIETFKGCLAMANKG--PNS 185
                    799*******************766888********************999954..53434444...58*****.677889********97..8** PP

  Pro_isomerase 103 agsqFfItlkeaphldgkytvFGkVveGmdvvekiekvetde.erpkknvkivs 155
                    ++sqFfIt++ +phldgk+tvFG+V++G + ++++e  +++e  +p  ++ iv+
     EFC39197.1 186 NNSQFFITMASTPHLDGKHTVFGRVLRGWEFLQRLELIRVNEqYKPAVDIMIVN 239
                    *************************************99999889998888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (254 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       750  (0.0418317); expected 358.6 (0.02)
Passed bias filter:                      657  (0.0366445); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.42
# Mc/sec: 1811.25
//
Query:       EFC39198.1  [L=613]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      3e-34  118.4   0.0    5.1e-34  117.6   0.0    1.4  1  Peptidase_C2  Calpain family cysteine protease
  ------ inclusion threshold ------
       0.06   13.0   0.1       0.14   11.8   0.1    1.5  1  Sec16_C       Sec23-binding domain of Sec16
       0.22   11.9   2.3        7.5    7.0   0.0    3.7  2  DUF2369       Uncharacterised conserved protein (DUF2369)


Domain annotation for each model (and alignments):
>> Peptidase_C2  Calpain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.6   0.0   8.6e-38   5.1e-34       1     135 [.     477     611 ..     477     613 .] 0.89

  Alignments for each domain:
  == domain 1  score: 117.6 bits;  conditional E-value: 8.6e-38
  Peptidase_C2   1 feDpeFpaeesslfy..kkskkkkkkveWkRpkeiven.pkfivdgasrtdikqGelgdCwllaaiasltlkekllkrvvpkeqsfeekyaGifhfr 94 
                   f Dp+Fpae++  +y  + s k+ ++++W R++ei+ +  ++++dg+s  dikqG lgdCw+l+a+a+++ ++ l++r++ ++ s++   aGi++++
    EFC39198.1 477 FVDPDFPAETDVSVYesSFSGKRIEDIKWSRASEILGHnYEIFCDGISADDIKQGCLGDCWMLSAVAAIAAQPYLIERLFSTR-SVN--KAGIYELN 570
                   89******99988884435566778**********98537899**************************************99.444..49****** PP

  Peptidase_C2  95 fwrfgewvdvvvDDrlPt.vngklvfvksaeknefWsalleK 135
                   ++  gew+ vvvDD++Pt + ++ +f+++ ++ e+W+ lleK
    EFC39198.1 571 ICTGGEWTRVVVDDLFPTdQYNNSLFAHN-HSAELWVMLLEK 611
                   ******************65688999999.559********9 PP

>> Sec16_C  Sec23-binding domain of Sec16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   2.3e-05      0.14     127     199 ..     342     412 ..     332     425 .. 0.57

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 2.3e-05
                 HHHHTT-HHHHHHHHHHT-SSS..............BSSTTS--B--SSSTTSHHHHHHHHHHHHHH.HT.... CS
     Sec16_C 127 lLaskgrveaahicyllalsqtslfggld.spsarlvllgadhvkfessfakdlesilltEiyEfalslspaak 199
                 lLa k+++e ah+cyl+ ++ ++   ++d s+++++++ + +++  +s+f +d   +    +y +a+++s +a+
  EFC39198.1 342 LLAVKNNCEKAHMCYLFMKQMQNCTMDTDySDQNKMMVKPYQTKLYSSIFLTD---VTKPFVYSYAYQVSRVAD 412
                 56779*************33333333333033334444444444444444333...233335666666665554 PP

>> DUF2369  Uncharacterised conserved protein (DUF2369)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   1.8      0.18   1.1e+03       7      27 ..     145     167 ..     140     205 .. 0.69
   2 ?    7.0   0.0    0.0013       7.5       2      30 ..     572     601 ..     571     608 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.18
     DUF2369   7 tkvtlseLkpdtqY..yfdVFvv 27 
                 +  tl++L+p ++Y  ++d++  
  EFC39198.1 145 NYTTLQNLTPTKTYedFVDLYDL 167
                 66788888888888777777744 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0013
     DUF2369   2 Cvgkk.tkvtlseLkpdtqYyfdVFvvdqk 30 
                 C+g + t v++++L p  qY  ++F+ ++ 
  EFC39198.1 572 CTGGEwTRVVVDDLFPTDQYNNSLFAHNHS 601
                 998888********************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (613 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       643  (0.0358637); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 3749.92
//
Query:       EFC39199.1  [L=296]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.1e-46  157.2  13.4    3.8e-45  155.0  13.4    1.8  1  SARAF     SOCE-associated regulatory factor of calcium homoeo
  ------ inclusion threshold ------
       0.11   13.1  11.7      0.077   13.7   3.9    2.9  2  RCR       Chitin synthesis regulation, resistance to Congo re
        0.2   11.9   0.1        1.9    8.8   0.0    2.1  2  DUF2530   Protein of unknown function (DUF2530)
       0.23   11.6   0.1       0.23   11.6   0.1    2.2  3  DUF5518   Family of unknown function (DUF5518)


Domain annotation for each model (and alignments):
>> SARAF  SOCE-associated regulatory factor of calcium homoeostasis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  155.0  13.4   8.4e-49   3.8e-45       7     327 ..      18     291 ..       8     296 .] 0.65

  Alignments for each domain:
  == domain 1  score: 155.0 bits;  conditional E-value: 8.4e-49
       SARAF   7 vlataaaaakkkkdkvlLsdvqaLTLrkgrlTtaRRvspipQLkCvggsagsaaslyevdvvrCtNkGsdydgedvqWeCkadLpeelklGstdViCEG 105
                 +l+ ++  ++  +d++ L++++++TL+k++ TtaRR++p+pQLkC+ +  +   + ye+d v C  +G         W+C+a+L +++k+G+++V CEG
  EFC39199.1  18 TLS-TQQGSNIGNDAIHLTQIKSITLYKNAWTTARRSHPVPQLKCI-S--KP--DNYEPDQVECSYEGN-------GWRCNAKLRSNYKFGKMNVNCEG 103
                 222.233333348*********************************.5..44..4468***********.......9********************** PP

       SARAF 106 YdspdDpyvLkGSCGveYrLelteegekkykkseeskkeeekkeevkkksssssasllfvvlvllviayivykaflaaeeereaeaeggrrgegggggg 204
                 Y+++ D+ vLkGSCG+eY+Le++++ ++++++++ +++          ++ ss  s+ +v++vl+vi+ i+ +   ++++         ++++++++ +
  EFC39199.1 104 YRYSGDDLVLKGSCGLEYTLEYNQKPQSNQQQQHYRHE--P----I-PSNPSSLGSFWIVIIVLVVIGCIWLSKQNSSST--------IQSNNQQPYPS 187
                 **********************9998877765443332..1....1.223333444446666777777666554442222........23333333322 PP

       SARAF 205 ggggpgseeeqddpPppy..sltksqkpssssessqqgeqeeswrpGFWtGlatGaaaGYlagrrraqneeteeeekeksssWgsssegssssssssss 301
                             d  p y  +l+++  p      s++++q++s+ p F  G+a+G aa  l+ ++r++  +  +      +s+ +ss++ ++  +++s+
  EFC39199.1 188 MYP---------DVNPNYnpDLHQTFVP------SSSSSQTSSTIPTFLAGAAAGYAASSLYNSQRNSGATGGN------GSYFESSSNDRNYGNHYSN 265
                 222.........2334441111122222......22333456788***98888888888887777775444443......3444444445555555555 PP

       SARAF 302 sssassssssssssssstrestGFGg 327
                  ++++++s s++  +  tr  t +G 
  EFC39199.1 266 YENQTYHSYSHHDDDDDTRDHTVYGI 291
                 55666666666777778888888884 PP

>> RCR  Chitin synthesis regulation, resistance to Congo red
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   1.0     0.031   1.4e+02       9     101 ..       7     136 ..       3     149 .. 0.54
   2 ?   13.7   3.9   1.7e-05     0.077       7      84 ..     153     239 ..     149     288 .. 0.71

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.031
         RCR   9 ivlillvllltlrvakrRrrrGlqplygtgWlvsa.....................pppPsYgqsqqqynqa....esltsatvptyt.pnaneedaGy 81 
                 ++ ++++++++++++++ ++ G + ++ t   + +                       p +Y++ q + + +    +  +++   +y+  + n + +Gy
  EFC39199.1   7 LITFIALIFSITLSTQQGSNIGNDAIHLTQIKSITlyknawttarrshpvpqlkciSKPDNYEPDQVECSYEgngwR-CNAKLRSNYKfGKMNVNCEGY 104
                 55666666666667777777777777766655332345566666777777778777667777777766555454431.334444445422225567777 PP

         RCR  82 ydqeGkfhe.............lqqPqqayqre 101
                    +G                  q+Pq+++q++
  EFC39199.1 105 RY-SGDDLVlkgscgleytleyNQKPQSNQQQQ 136
                 44.443333445555555566555555544433 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 1.7e-05
         RCR   7 iiivlillvllltlrvakrRrrrGlqplygtgWlvs.apppPsYgqsqqqynqa..es.ltsatvptytpnaneedaGyyd........q 84 
                  +iv+i+lv++++++ +k+++++  q +  + + +      P+Y++  +q+  +  +s +ts+t pt+ +      aGy          +
  EFC39199.1 153 FWIVIIVLVVIGCIWLSKQNSSSTIQSNNQQPYPSMyPDVNPNYNPDLHQTFVPssSSsQTSSTIPTFLAG---AAAGYAAsslynsqrN 239
                 68999****************************96667899*****9998887788555999999**9999...5677755333333331 PP

>> DUF2530  Protein of unknown function (DUF2530)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.19   8.3e+02       4      23 ..     144     163 ..     141     175 .. 0.70
   2 ?    8.8   0.0   0.00042       1.9      35      68 ..     210     243 ..     203     248 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.19
     DUF2530   4 PeLprrLtdprpvivvgtll 23 
                 P  p++L   + vi+v +++
  EFC39199.1 144 PSNPSSLGSFWIVIIVLVVI 163
                 66677788888777776654 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00042
     DUF2530  35 gdaleswlpvclaGlvvGllGlaiflwQRrAaRr 68 
                  ++++s++p+ laG++ G  + +++  QR++   
  EFC39199.1 210 SSQTSSTIPTFLAGAAAGYAASSLYNSQRNSGAT 243
                 4688899**********************87655 PP

>> DUF5518  Family of unknown function (DUF5518)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       1.6   7.2e+03      99     103 ..      11      15 ..       4      26 .. 0.43
   2 ?   -0.8   0.1      0.37   1.7e+03     100     107 ..     156     163 ..     147     173 .. 0.47
   3 ?   11.6   0.1   5.2e-05      0.23      16      55 ..     204     243 ..     201     248 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.6
     DUF5518  99 llvvl 103
                 +++++
  EFC39199.1  11 IALIF 15 
                 11111 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.37
     DUF5518 100 lvvllvil 107
                 ++++lv++
  EFC39199.1 156 VIIVLVVI 163
                 11111111 PP

  == domain 3  score: 11.6 bits;  conditional E-value: 5.2e-05
     DUF5518  16 lllglllpsvgsllgllvgGlvaGylaggdskdgavaGal 55 
                 +++   + +++s ++++++G+ aGy a + + +    Ga 
  EFC39199.1 204 FVPSSSSSQTSSTIPTFLAGAAAGYAASSLYNSQRNSGAT 243
                 6666778899999*************98877666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (296 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1002  (0.0558871); expected 358.6 (0.02)
Passed bias filter:                      583  (0.0325172); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.45
# Mc/sec: 1971.43
//
Query:       EFC39200.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.083   12.8   0.0       0.11   12.4   0.0    1.2  1  Lipase_3  Lipase (class 3)


Domain annotation for each model (and alignments):
>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0     6e-06      0.11       4      60 ..      53     120 ..      50     135 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6e-06
                 E----------------EEE-HHHH-GTT-EEEHHHHHHHH...........S-HHHHHHHHHHHHHH CS
    Lipase_3   4 fRGtesakdwltdldfslteakellekeggkvhsgfleaye...........eslreqvlkelkrlle 60 
                 ++G +++kdw+ d++ +++++   +  ++ + +++f++++            ++++e++ ke+k++l 
  EFC39200.1  53 MKGNNERKDWILDFRGKHSKIMGIKLVSNLNYNEYFYKSLDdsnvyvpalylRKFYEDLVKEVKNWLL 120
                 79*********************99889**********************999999999999999543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.28s 00:00:00.76 Elapsed: 00:00:00.47
# Mc/sec: 964.88
//
Query:       EFC39201.1  [L=381]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-45  148.2  34.5     0.0003   20.6   0.2   14.7 15  LRR_6     Leucine Rich repeat
    8.2e-34  115.2  26.8    8.3e-08   31.9   3.4    6.7  7  LRR_8     Leucine rich repeat
    3.1e-27   94.2  34.3     0.0016   18.8   0.1    9.1 10  LRR_4     Leucine Rich repeats (2 copies)
    6.1e-20   68.7   6.6        7.1    7.6   0.0   12.9 14  LRR_1     Leucine Rich Repeat
    3.5e-06   26.6   1.8        0.7    9.4   0.1    4.1  5  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
       0.41   10.9   3.0        1.3    9.3   0.1    3.2  4  DUF424    Protein of unknown function (DUF424)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1     0.025        74       3      18 ..       2      17 ..       1      23 [. 0.85
   2 !   14.0   0.0   1.3e-05     0.039       5      24 .]      28      47 ..      26      47 .. 0.93
   3 !    9.2   0.1   0.00044       1.3       5      23 ..      52      70 ..      51      71 .. 0.93
   4 !    6.0   0.0    0.0049        15       5      24 .]      76      95 ..      73      95 .. 0.91
   5 !   11.2   0.1   0.00011      0.32       4      24 .]      99     119 ..      96     119 .. 0.91
   6 !   10.9   0.0   0.00013      0.39       4      22 ..     123     141 ..     121     143 .. 0.91
   7 ?   -0.7   0.0      0.68     2e+03       5      21 ..     148     164 ..     145     166 .. 0.76
   8 !   13.1   0.1   2.5e-05     0.076       5      24 .]     175     194 ..     173     194 .. 0.93
   9 !   15.2   0.1   5.3e-06     0.016       3      23 ..     197     217 ..     195     217 .. 0.93
  10 !   13.7   0.3   1.7e-05      0.05       5      24 .]     223     242 ..     221     242 .. 0.90
  11 !    9.4   0.1   0.00041       1.2       3      23 ..     245     265 ..     243     266 .. 0.90
  12 !   18.4   0.0   5.1e-07    0.0015       3      24 .]     269     290 ..     267     290 .. 0.92
  13 ?    0.7   0.0      0.24   7.1e+02       5      23 ..     295     313 ..     292     314 .. 0.84
  14 !   13.3   0.0   2.3e-05     0.068       5      22 ..     319     336 ..     316     337 .. 0.92
  15 !   20.6   0.2     1e-07    0.0003       3      23 ..     341     361 ..     339     362 .. 0.92

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.025
       LRR_6  3 thLteLdLsgNdIgDe 18
                ++L++L++ gN++ De
  EFC39201.1  2 QNLKSLSIVGNGLVDE 17
                79*********98665 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 1.3e-05
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt Ld+s N++g eGae+++
  EFC39201.1 28 LTLLDVSENKFGKEGAEKIS 47
                888***************96 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00044
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt+L++++N I DeGa+ +
  EFC39201.1 52 LTTLNINDNYILDEGAKFI 70
                9***************976 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.0049
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt L +++++I  eGa a++
  EFC39201.1 76 LTLLKMKYCEIREEGARAIS 95
                88899*************96 PP

  == domain 5  score: 11.2 bits;  conditional E-value: 0.00011
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt L+L gN IgD+Ga+ ++
  EFC39201.1  99 NLTFLNLHGNFIGDKGASYIS 119
                 8****************9875 PP

  == domain 6  score: 10.9 bits;  conditional E-value: 0.00013
       LRR_6   4 hLteLdLsgNdIgDeGaea 22 
                 +Lt+L++ + +++ eGa  
  EFC39201.1 123 NLTHLNVGSTQLTAEGARH 141
                 7***************975 PP

  == domain 7  score: -0.7 bits;  conditional E-value: 0.68
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 L++L +  N+Ig +Ga+
  EFC39201.1 148 LKSLLIHTNQIGHQGAK 164
                 6666666699*999986 PP

  == domain 8  score: 13.1 bits;  conditional E-value: 2.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+sgN I D+G++ L+
  EFC39201.1 175 LTSLDVSGNSILDQGVQYLS 194
                 9***************9885 PP

  == domain 9  score: 15.2 bits;  conditional E-value: 5.3e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt+Ld+ +N++g +G+e++
  EFC39201.1 197 SNLTHLDIGSNHVGVKGIESI 217
                 79****************987 PP

  == domain 10  score: 13.7 bits;  conditional E-value: 1.7e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +L++s+Nd+g +Ga+ ++
  EFC39201.1 223 LISLNVSSNDLGSSGAKLIS 242
                 569*************9985 PP

  == domain 11  score: 9.4 bits;  conditional E-value: 0.00041
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt+L++s N + +eGa+ +
  EFC39201.1 245 SNLTSLNISANRLLGEGAKFI 265
                 79***************9976 PP

  == domain 12  score: 18.4 bits;  conditional E-value: 5.1e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 +++t L ++ NdIgDeGa+ ++
  EFC39201.1 269 HNVTILVIRNNDIGDEGAKFIC 290
                 689****************987 PP

  == domain 13  score: 0.7 bits;  conditional E-value: 0.24
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++L+  +N I+ +G e++
  EFC39201.1 295 LKSLNAVYNRISSKGFESI 313
                 88888889*****998877 PP

  == domain 14  score: 13.3 bits;  conditional E-value: 2.3e-05
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+Ld+ +N I+ +Ga++
  EFC39201.1 319 LTSLDIGYNSIDSKGAKS 336
                 9***************96 PP

  == domain 15  score: 20.6 bits;  conditional E-value: 1e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt+L++++N I+DeG++a+
  EFC39201.1 341 KNLTSLNVRSNMIDDEGLKAI 361
                 68******************9 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.8   8.8e-08   0.00026       2      61 .]       3      62 ..       2      62 .. 0.97
   2 !   28.0   0.3   4.5e-10   1.4e-06       2      59 ..      51     108 ..      50     110 .. 0.97
   3 !   14.4   0.5   7.8e-06     0.023      22      61 .]     119     158 ..     114     158 .. 0.89
   4 !   28.3   0.9   3.6e-10   1.1e-06       2      61 .]     174     233 ..     173     233 .. 0.97
   5 !   31.9   3.4   2.8e-11   8.3e-08       1      61 []     197     257 ..     197     257 .. 0.98
   6 !   23.6   0.4   1.1e-08   3.3e-05       1      61 []     245     305 ..     245     305 .. 0.98
   7 !   30.4   0.6     8e-11   2.4e-07       2      61 .]     294     353 ..     293     353 .. 0.97

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 8.8e-08
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                nL+sL++  N l + + +  + +++L+ Ld s+N+     ++ +sg+  L+ L++++N +
  EFC39201.1  3 NLKSLSIVGNGLVDEHLKEISEMKGLTLLDVSENKFGKEGAEKISGMVGLTTLNINDNYI 62
                9*********************************************************76 PP

  == domain 2  score: 28.0 bits;  conditional E-value: 4.5e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt+L++++N++ + + ++  ++++L+ L++++ +++   ++a+s L++L++L+L gN
  EFC39201.1  51 GLTTLNINDNYILDEGAKFIGTMKQLTLLKMKYCEIREEGARAISELKNLTFLNLHGN 108
                 59*******************************************************9 PP

  == domain 3  score: 14.4 bits;  conditional E-value: 7.8e-06
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + + nL++L+ ++ +lt   ++  sgL++L+sL +  N++
  EFC39201.1 119 SEMVNLTHLNVGSTQLTAEGARHVSGLKNLKSLLIHTNQI 158
                 56789999*********99999*********999999987 PP

  == domain 4  score: 28.3 bits;  conditional E-value: 3.6e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsLd+s N++ + + +  + +snL++Ld+++N   +   +++ g++ L sL++s+N+L
  EFC39201.1 174 GLTSLDVSGNSILDQGVQYLSEMSNLTHLDIGSNHVGVKGIESIIGMKGLISLNVSSNDL 233
                 69*********************************9999999****************98 PP

  == domain 5  score: 31.9 bits;  conditional E-value: 2.8e-11
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nLt Ld+ +N+  + + e+  g+++L +L+ s+N l +  ++ +sg+++L+sL++s NrL
  EFC39201.1 197 SNLTHLDIGSNHVGVKGIESIIGMKGLISLNVSSNDLGSSGAKLISGMSNLTSLNISANRL 257
                 69*********************************************************98 PP

  == domain 6  score: 23.6 bits;  conditional E-value: 1.1e-08
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nLtsL++s Nrl + + ++   ++n+++L ++nN +    ++ +  +++L+sL+  +Nr+
  EFC39201.1 245 SNLTSLNISANRLLGEGAKFIGEMHNVTILVIRNNDIGDEGAKFICKMKQLKSLNAVYNRI 305
                 69*********************************************************97 PP

  == domain 7  score: 30.4 bits;  conditional E-value: 8e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+sL+   Nr++s + e+ + +++L++Ld+++N++++  +++ + L++L+sL++++N +
  EFC39201.1 294 QLKSLNAVYNRISSKGFESISEMKQLTSLDIGYNSIDSKGAKSVRKLKNLTSLNVRSNMI 353
                 799*******************************************************76 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.2   0.00023       0.7       1      33 [.       2      36 ..       2      41 .. 0.78
   2 !   11.7   0.3   8.9e-05      0.27       2      37 ..      27      63 ..      26      69 .. 0.85
   3 !    7.8   0.1    0.0016       4.6       2      31 ..      51      82 ..      50      89 .. 0.82
   4 !   11.0   0.3   0.00015      0.44       3      38 ..      76     112 ..      74     116 .. 0.69
   5 !   17.3   0.3   1.6e-06    0.0048       2      36 ..     123     158 ..     122     160 .. 0.83
   6 !   18.8   0.1   5.2e-07    0.0016       2      33 ..     174     207 ..     173     218 .. 0.86
   7 !   17.1   2.1   1.8e-06    0.0054       2      35 ..     222     257 ..     221     260 .. 0.84
   8 !   13.1   0.0   3.3e-05     0.098       2      36 ..     270     305 ..     269     314 .. 0.84
   9 !   15.2   0.1   7.5e-06     0.022       1      40 [.     293     330 ..     293     333 .. 0.79
  10 !   16.8   0.6   2.2e-06    0.0066       1      38 [.     317     355 ..     317     360 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00023
                SS--EEE--SS-.....--E-S-HHH-TT--EEE-.-S CS
       LRR_4  1 pnLevLdLsnNq.....ltdiplleklpnLkeLdLsgN 33
                +nL++L++ +N      l++i+    ++ L+ Ld+s+N
  EFC39201.1  2 QNLKSLSIVGNGlvdehLKEISE---MKGLTLLDVSEN 36
                69********9944444444444...*********999 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 8.9e-05
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37
                 L+ Ld s N+  + +   ++++  L++L++++N +i 
  EFC39201.1 27 GLTLLDVSENKFGKEGAekISGMVGLTTLNINDN-YIL 63
                7999****99***999966558*********777.774 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0016
                S--EEE--SS---E-S-.HHH.-TT--EEE-. CS
       LRR_4  2 nLevLdLsnNqltdipl.lek.lpnLkeLdLs 31
                 L++L++++N + d +  + + +++L+ L + 
  EFC39201.1 51 GLTTLNINDNYILDEGAkFIGtMKQLTLLKMK 82
                699******99999888966669999999884 PP

  == domain 4  score: 11.0 bits;  conditional E-value: 0.00015
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 L+ L    + +++ +   ++ l+nL+ L+L+gN +i+d
  EFC39201.1  76 LTLLKMKYCEIREEGAraISELKNLTFLNLHGN-FIGD 112
                 555556666666655543334*********888.8865 PP

  == domain 5  score: 17.3 bits;  conditional E-value: 1.6e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 nL++L+ +++qlt  +    ++l+nLk+L L + n+i
  EFC39201.1 123 NLTHLNVGSTQLTAEGArhVSGLKNLKSL-LIHTNQI 158
                 9************877764336*******.9888898 PP

  == domain 6  score: 18.8 bits;  conditional E-value: 5.2e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                  L++Ld s+N + d +   l+ + nL++Ld+ +N
  EFC39201.1 174 GLTSLDVSGNSILDQGVqyLSEMSNLTHLDIGSN 207
                 69*********99999987778*********656 PP

  == domain 7  score: 17.1 bits;  conditional E-value: 1.8e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                  L++L+ s+N l + +   ++++ nL++L++s N l
  EFC39201.1 222 GLISLNVSSNDLGSSGAklISGMSNLTSLNISANRL 257
                 79***********988894446*********99955 PP

  == domain 8  score: 13.1 bits;  conditional E-value: 3.3e-05
                 S--EEE--SS---E-S-.HH.H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.le.klpnLkeLdLsgNnli 36 
                 n ++L ++nN + d +  +  k+++Lk+L+   N +i
  EFC39201.1 270 NVTILVIRNNDIGDEGAkFIcKMKQLKSLNAVYN-RI 305
                 899***********99995547********6677.55 PP

  == domain 9  score: 15.2 bits;  conditional E-value: 7.5e-06
                 SS--EEE--SS---E-S-..HHH.-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitdld 40 
                 ++L++L+   N++++ ++  + + +++L++Ld+  N    ++d
  EFC39201.1 293 KQLKSLNAVYNRISSKGFesI-SeMKQLTSLDIGYN----SID 330
                 589***********8666543.44*********778....554 PP

  == domain 10  score: 16.8 bits;  conditional E-value: 2.2e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++Ld++ N + + +    +kl+nL++L++ + n i+d
  EFC39201.1 317 KQLTSLDIGYNSIDSKGAksVRKLKNLTSLNV-RSNMIDD 355
                 58************866675559*********.5447754 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0      0.12   3.7e+02       1      15 [.       3      17 ..       3      25 .. 0.78
   2 ?   -1.1   0.0       1.7     5e+03       2      12 ..      28      38 ..      27      47 .. 0.80
   3 ?    4.4   0.0     0.027        79       2      17 ..      52      67 ..      51      73 .. 0.82
   4 !    7.6   0.0    0.0024       7.1       1      21 [.      99     119 ..      99     121 .. 0.88
   5 ?    4.5   0.0     0.026        77       1      22 [.     123     144 ..     123     145 .. 0.85
   6 ?   -1.3   0.0         2     6e+03       1      15 [.     147     161 ..     147     168 .. 0.73
   7 !    5.9   0.0    0.0085        25       2      19 ..     175     192 ..     174     196 .. 0.79
   8 !    7.4   0.0    0.0027       8.1       1      19 [.     198     216 ..     198     220 .. 0.81
   9 ?    3.7   0.0     0.046   1.4e+02       2      17 ..     223     238 ..     222     244 .. 0.77
  10 ?    5.4   0.0     0.012        36       1      18 [.     246     263 ..     246     268 .. 0.83
  11 ?    0.5   0.0      0.52   1.6e+03       2      22 ..     271     291 ..     270     292 .. 0.77
  12 ?    1.0   0.0      0.34     1e+03       1      21 [.     294     314 ..     294     316 .. 0.82
  13 !    7.6   0.0    0.0025       7.4       1      23 []     318     340 ..     318     340 .. 0.87
  14 ?    4.2   0.0     0.031        92       1      17 [.     342     358 ..     342     364 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.12
       LRR_1  1 nLrhLdLsnnpllgl 15
                nL++L + +n l + 
  EFC39201.1  3 NLKSLSIVGNGLVDE 17
                8*********98544 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.7
       LRR_1  2 LrhLdLsnnpl 12
                L+ Ld+s n +
  EFC39201.1 28 LTLLDVSENKF 38
                889****9987 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.027
       LRR_1  2 LrhLdLsnnpllglpp 17
                L++L++++n +l+ ++
  EFC39201.1 52 LTTLNINDNYILDEGA 67
                99*******9977655 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.0024
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL+ L+L +n+++++++++++
  EFC39201.1  99 NLTFLNLHGNFIGDKGASYIS 119
                 8***********999988776 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.026
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL+hL++++ +l+  ++++ ++
  EFC39201.1 123 NLTHLNVGSTQLTAEGARHVSG 144
                 8********9998888888776 PP

  == domain 6  score: -1.3 bits;  conditional E-value: 2
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL++L +  n++++ 
  EFC39201.1 147 NLKSLLIHTNQIGHQ 161
                 89**99977777555 PP

  == domain 7  score: 5.9 bits;  conditional E-value: 0.0085
       LRR_1   2 LrhLdLsnnpllglppns 19 
                 L++Ld+s+n++l+ + ++
  EFC39201.1 175 LTSLDVSGNSILDQGVQY 192
                 89********97766655 PP

  == domain 8  score: 7.4 bits;  conditional E-value: 0.0027
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL+hLd+++n+ + ++++s
  EFC39201.1 198 NLTHLDIGSNHVGVKGIES 216
                 8*********976666655 PP

  == domain 9  score: 3.7 bits;  conditional E-value: 0.046
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L +L++s+n l++ ++
  EFC39201.1 223 LISLNVSSNDLGSSGA 238
                 889*******976555 PP

  == domain 10  score: 5.4 bits;  conditional E-value: 0.012
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 nL++L++s n+llg ++ 
  EFC39201.1 246 NLTSLNISANRLLGEGAK 263
                 8**********9887665 PP

  == domain 11  score: 0.5 bits;  conditional E-value: 0.52
       LRR_1   2 LrhLdLsnnpllglppnsfqn 22 
                  + L ++nn +++ ++  +++
  EFC39201.1 271 VTILVIRNNDIGDEGAKFICK 291
                 568999****98888777665 PP

  == domain 12  score: 1.0 bits;  conditional E-value: 0.34
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L+  +n++++++ +s++
  EFC39201.1 294 QLKSLNAVYNRISSKGFESIS 314
                 59****999999888877776 PP

  == domain 13  score: 7.6 bits;  conditional E-value: 0.0025
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L++Ld+++n+++++++ s  +L
  EFC39201.1 318 QLTSLDIGYNSIDSKGAKSVRKL 340
                 599*********99999887765 PP

  == domain 14  score: 4.2 bits;  conditional E-value: 0.031
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL++L++++n +++ + 
  EFC39201.1 342 NLTSLNVRSNMIDDEGL 358
                 8*********9866655 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.55   1.6e+03     113     147 ..       2      33 ..       1      46 [. 0.58
   2 !    7.5   0.0   0.00087       2.6      59     128 ..      45     113 ..      27     129 .. 0.74
   3 !    5.2   0.0    0.0044        13      63     125 ..     145     209 ..     140     214 .. 0.77
   4 !    9.4   0.1   0.00024       0.7      63     129 ..     244     309 ..     221     340 .. 0.81
   5 !    5.3   0.1    0.0041        12      63     125 ..     292     353 ..     286     379 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.55
       LRR_9 113 kklellsllknpvtnkkeyrlyviyklkqlrlldf 147
                 ++l++ls++ n ++++ +  l  i  +k l+lld 
  EFC39201.1   2 QNLKSLSIVGNGLVDE-H--LKEISEMKGLTLLDV 33 
                 5677777777776653.2..233555555555554 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.00087
       LRR_9  59 gfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                  +  +  l tl +n+n i+  + ++  ++ +l+ l +   e++e +    + +lk+l++l l  n + +k
  EFC39201.1  45 KISGMVGLTTLNINDNYILDEGAKFIGTMKQLTLLKMKYCEIREEGA-RAISELKNLTFLNLHGNFIGDK 113
                 55566778899999999998888888888888888888888888777.8899999999999988877665 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0044
       LRR_9  63 lkrlktlllnnnrivriaegleevlPn...leelvltnnelqeladldPlaslkklellsllknpv 125
                 lk lk+ll+  n+i + + +   ++     l++l +++n++ + + ++ l ++++l+ l + +n v
  EFC39201.1 145 LKNLKSLLIHTNQIGHQGAKWISTMKDlegLTSLDVSGNSILDQG-VQYLSEMSNLTHLDIGSNHV 209
                 799************999887666555011566778888887765.58999999999999988877 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.00024
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                 +  l +l ++ nr++  + ++   + n++ lv+ nn + + +  + + ++k+l++l  + n +++k 
  EFC39201.1 244 MSNLTSLNISANRLLGEGAKFIGEMHNVTILVIRNNDIGDEGA-KFICKMKQLKSLNAVYNRISSKG 309
                 778999*********999999999***************9988.999*********99999998874 PP

  == domain 5  score: 5.3 bits;  conditional E-value: 0.0041
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 +k+lk+l    nri   + +    + +l++l +  n++++ +  + + +lk+l++l + +n +
  EFC39201.1 292 MKQLKSLNAVYNRISSKGFESISEMKQLTSLDIGYNSIDSKGA-KSVRKLKNLTSLNVRSNMI 353
                 8899999999999998887777778999999999999999887.8899999999998877755 PP

>> DUF424  Protein of unknown function (DUF424)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.45   1.3e+03      24      61 ..      26      60 ..       2      68 .. 0.65
   2 ?    9.3   0.1   0.00044       1.3      19      61 ..      66     108 ..      50     114 .. 0.85
   3 ?   -1.8   0.0       1.3   3.9e+03      45      62 ..     239     256 ..     221     279 .. 0.53
   4 ?   -1.1   0.0      0.77   2.3e+03      44      57 ..     334     347 ..     285     356 .. 0.63

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.45
                ETTEEEE--HHHH--EEE-HHHHHHHHHHHEEEEEESH CS
      DUF424 24 egelllnvsegfyggelaseeeaikeLekatiaNivge 61
                +g +ll vse  +g+e a   e i+ +  +t  Ni ++
  EFC39201.1 26 KGLTLLDVSENKFGKEGA---EKISGMVGLTTLNINDN 60
                345778888888888877...55555666666666655 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00044
                 T-EEEETTEEEE--HHHH--EEE-HHHHHHHHHHHEEEEEESH CS
      DUF424  19 gktfkegelllnvsegfyggelaseeeaikeLekatiaNivge 61 
                 g +f   + +l++ +  y++  ++ ++ai+eL+++t  N++g+
  EFC39201.1  66 GAKFIGTMKQLTLLKMKYCEIREEGARAISELKNLTFLNLHGN 108
                 678999999********************************96 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.3
                 HHHHHHHHHEEEEEESHH CS
      DUF424  45 eaikeLekatiaNivgee 62 
                 ++i+ + ++t  Ni  ++
  EFC39201.1 239 KLISGMSNLTSLNISANR 256
                 445555555555554333 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 0.77
                 HHHHHHHHHHEEEE CS
      DUF424  44 eeaikeLekatiaN 57 
                 ++++++L+++t  N
  EFC39201.1 334 AKSVRKLKNLTSLN 347
                 34555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       349  (0.0194657); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2469.43
//
Query:       EFC39202.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-13   50.8   9.8    2.1e-13   50.4   9.8    1.2  1  TM2       TM2 domain


Domain annotation for each model (and alignments):
>> TM2  TM2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.4   9.8   1.2e-17   2.1e-13       6      51 .]       5      51 ..       1      51 [. 0.95

  Alignments for each domain:
  == domain 1  score: 50.4 bits;  conditional E-value: 1.2e-17
         TM2  6 lvaylLwf..fLGglGvHRFYlGktgsGvlqlltfvGglgiwwlidli 51
                +vaylLw+    G++G+HRFYl  ++ Gv++++t  G++g+++lidli
  EFC39202.1  5 GVAYLLWLgcCIGFFGLHRFYLDSVILGVIWFCTA-GLFGFGQLIDLI 51
                89*****9888************************.**********97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       553  (0.0308439); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 751.93
//
Query:       EFC39203.1  [L=315]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0022   18.3   0.2     0.0054   17.0   0.3    1.6  2  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.3     3e-07    0.0054       2     100 ..      12     109 ..      11     112 .. 0.72
   2 ?   -2.9   0.0      0.46   8.2e+03      41      59 ..     236     255 ..     221     268 .. 0.63

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3e-07
                 EEEEEEEEEESSSSSSTTSSCEEEEEEEEECEEEEEE-SCSSSS...S.SEE..EEEEEE.EESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHT CS
          C2   2 klevtvieAknLpnkdkkgssdpyvkvsldgkqkakTrviknsl...n.PvW..nekftf.evaeleeakLeveVfdndrlskddfiGkveiplstlls 93 
                 +l+ t+i+ +nL+        ++y+ +++ +++ +k ++ +++l   n  +W  n ++ f e++e  +++L++eV d+++   d++iG ++ +l++l +
  EFC39203.1  12 QLSATIIKVENLQTD----PNSVYAILTF-NQVQKKVSTADKNLegkNsYEWsdNNNVLFkEIPEFCNERLKIEVRDKQS---DKLIGMTTTSLESLPK 102
                 688999999999777....4578999*99.444444444566652333248966455555477778899********877...*************888 PP

                 THHHHEE CS
          C2  94 geeaegw 100
                 + e+++ 
  EFC39203.1 103 NLEITRK 109
                 7777665 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 0.46
                 C..SSSSSSEEEEEEEEEESC CS
          C2  41 i..knslnPvWnekftfevae 59 
                 i  k+s +P+++ ++ +++ +
  EFC39203.1 236 IpyKKS-EPIFDLSVDVNIIH 255
                 443555.67776666665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       528  (0.0294495); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.45
# Mc/sec: 2118.47
//
Query:       EFC39204.1  [L=507]
Description: poly (ADP-ribose) glycohydrolase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.8e-75  252.2   2.7    1.1e-74  251.7   2.7    1.2  1  PARG_cat  Poly (ADP-ribose) glycohydrolase (PARG)


Domain annotation for each model (and alignments):
>> PARG_cat  Poly (ADP-ribose) glycohydrolase (PARG)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  251.7   2.7   6.3e-79   1.1e-74       6     331 ..     119     451 ..     114     459 .. 0.91

  Alignments for each domain:
  == domain 1  score: 251.7 bits;  conditional E-value: 6.3e-79
    PARG_cat   6 sekffeevlpklaklalklpslleke.lrlLkqqesesvtlsqeqiaallanaFfclfprqernkseekklpsinfdrlfssessseskaeklkcllhY 103
                 +++f+e+v+pk+a+ +l+l++ +++  +++L  + s+ v l+++qi +++++aF clf++  r + ++k++ +++f  ++     s ++++ l +l+hY
  EFC39204.1 119 EKEFMEKVVPKIAQWILDLEREFPSGkIPVLMMNASGVVRLTKRQIRSIMSCAFCCLFRE--RGDVSKKNMGVFEFGLFW-----SVASQNFLMSLFHY 210
                 789******************999977*******************************99..555889999999987655.....4788899******* PP

    PARG_cat 104 Fervt........ekepegvvsferkvlsk...kekiedwsksekklskveveseglIedqskgalqvdFAnkyiGGgvlsrGcvQEeirflinPEliv 191
                 Fer++        ++   +++ ferkvl++       e++ ks++k++++ ++ +g+I+d + ++l vdFAn +iGG vl+  + QEei f+ +PEl++
  EFC39204.1 211 FERMYkldndsstSSSLDEIILFERKVLKNnyrRFIEEEICKSQQKMCPLLFK-QGKIQD-NLNHLMVDFANCMIGGHVLGGAVAQEEILFVECPELFA 307
                 *******99876555555**********99865444578889999****9887.8*****.99******************9999************** PP

    PARG_cat 192 smLfteklednealvivgaerfssytGYassfrfagdyvdktprdslgrrkteivaiDAlefkkeekekqykkekilRelnKAyvgFksqekeke.... 286
                 s+L++++++ +e++  +g er+s+ +GY +s+++ + y d++p+ ++  rk++++a+DAl+        q++ke ilRe+ K  ++F+s+e+       
  EFC39204.1 308 SILICPQMQVHETIKFTGFERYSNLKGYIKSMTY-ETYLDNQPVIENV-RKNQLIAMDALQ---GVGIFQFQKEFILREIFKTTCAFTSKENDFLkdss 401
                 ********************************99.7899999999999.8999********...5699********************99887778999 PP

    PARG_cat 287 ....eeekvgiaTGnWGCGaFgGdpeLKaliQllAasqagre.lvyytfg 331
                     + e+ +ia+G WGCG+FgGd++LK++iQ+l+a +++r+ l+ + f+
  EFC39204.1 402 sdlpTLENEPIASGFWGCGMFGGDKQLKTIIQWLSATLCNRPsLTIHLFS 451
                 99999999*********************************998888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       770  (0.0429472); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.34s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 3121.05
//
Query:       EFC39205.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.6e-38  130.0   0.1    1.1e-37  129.8   0.1    1.1  1  14-3-3    14-3-3 protein


Domain annotation for each model (and alignments):
>> 14-3-3  14-3-3 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  129.8   0.1   5.9e-42   1.1e-37      13     222 .]      22     235 ..      19     235 .. 0.88

  Alignments for each domain:
  == domain 1  score: 129.8 bits;  conditional E-value: 5.9e-42
                 HHHHHHCHHHHC..SS--...-HCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCTCC..HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHCH.-S CS
      14-3-3  13 dmveymkkvvel..keeL...skeernlLsvayKnvvgarRaswrvlssieqkeeske..ekkvelikeyrekiekeLkeiceevlelldktlipkats 104
                 d +++ kk + +  +++L   +keern +   +K ++ a+  s+r ++ ++q+e++ +   ++ +li++y  ki+ke+ +  +e++ l+d++l ++  +
  EFC39205.1  22 DLIKFTKKSIIEilDSDLpipTKEERNWIGGCFKRTIPAKICSYRSIRVLQQREQNASssPHHRQLIDDYLFKIAKEIIDDSTEMIGLIDEILKRDLLD 120
                 5555555544334644444479******************9999999988777777666788999*****************************889** PP

                 HHHHHHHHHHHHHHHHHHHCC--HHHHHHHHHHHHHHHHHHHHHHHTTTGCC-HHHHHHHHHHHHHHHCTT--HHHHHHHHHHHHHCCHCCCCCS.TTT CS
      14-3-3 105 eeskvfylkmkgDyyRYlaEfaegeekkeaaekakeaYeeAleiakkelqpthpirLglaLNySVflyeilnspekAcelakkafdeaiaeldelsees 203
                 +e++++y+++kgDyy+ l  ++ +  +++ +    +++e+  +   ++++p + i L   L  SVf+ye++n++ekA+e+ak+af+ a+  +del+ee 
  EFC39205.1 121 DEDRLYYCHLKGDYYKMLFAIDGE--QDKWKLLYCQSFEDGRDSL-EKVSPLNVIGLRTSLAASVFYYEVMNDQEKAVEIAKSAFNAAVPLFDELDEEV 216
                 ******************999955..555555558999***9998.88*************************************************** PP

                 HHHHHHHHHHHHHHHHHHC CS
      14-3-3 204 ykdstlilqlLrdnltlWt 222
                   +  ++lq+LrdnltlWt
  EFC39205.1 217 TSEILMLLQMLRDNLTLWT 235
                 ******************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       603  (0.0336327); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.57
# Mc/sec: 1281.85
//
Query:       EFC39206.1  [L=875]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (875 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       937  (0.0522617); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.76u 0.38s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 4932.50
//
Query:       EFC39207.1  [L=129]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (129 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2161  (0.120531); expected 358.6 (0.02)
Passed bias filter:                      660  (0.0368119); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 733.64
//
Query:       EFC39208.1  [L=1465]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.028   14.7   3.1       0.14   12.4   0.0    3.5  4  DUF4771   Domain of unknown function (DUF4771)


Domain annotation for each model (and alignments):
>> DUF4771  Domain of unknown function (DUF4771)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.4     0.061   1.1e+03      52      88 ..      15      50 ..      12      79 .. 0.74
   2 ?   -3.9   0.0      0.81   1.4e+04     144     155 ..     510     521 ..     505     522 .. 0.83
   3 ?   -3.5   0.0      0.61   1.1e+04     111     137 ..     763     789 ..     724     795 .. 0.79
   4 ?   12.4   0.0   7.8e-06      0.14      38      87 ..    1000    1049 ..     978    1071 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.061
     DUF4771 52 ktYsekelkellkeskkvfekltelekkelkklpslk 88
                  + +++ ++l +++ +++e++ ++++++ kk+ + +
  EFC39208.1 15 GNFDHHQQNSLSSSNSRMMEMIRSQKERR-KKIKQQE 50
                56888888888888888888888888877.4444333 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 0.81
     DUF4771 144 slkktFfaYlpa 155
                  +k+ Ff Yl++
  EFC39208.1 510 WMKDNFFVYLSS 521
                 5899******97 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 0.61
     DUF4771 111 klkkeyrkklneklleesrllwlamen 137
                 k++++ ++kl e++l++   + + m++
  EFC39208.1 763 KVRNSTQSKLVEIVLQSFYECCMVMGS 789
                 678888899999999998888888876 PP

  == domain 4  score: 12.4 bits;  conditional E-value: 7.8e-06
     DUF4771   38 kvpvLleWikrRyGktYsekelkellkeskkvfekltelekkelkklpsl 87  
                  k+  L  Wi+ Ry   +s+ ++++  +e+ + f +lt+++++++k++ ++
  EFC39208.1 1000 KMQRLYFWISSRYSLLFSQVDISSRKSEKVQQFSNLTKQDESKFKQVKNH 1049
                  6778899************************************7775543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1465 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1291  (0.0720062); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.05u 0.34s 00:00:01.39 Elapsed: 00:00:00.55
# Mc/sec: 8054.51
//
Query:       EFC39209.1  [L=2148]
Description: serine/threonine protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.2e-25   90.2   0.1    3.2e-25   88.8   0.1    1.7  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.3e-24   87.4   0.0    4.3e-24   85.8   0.0    2.0  1  AAA_16         AAA ATPase domain
    3.6e-22   79.0   0.0    1.8e-21   76.7   0.0    2.2  1  Pkinase        Protein kinase domain
    6.1e-12   45.4   0.0    2.5e-11   43.3   0.0    2.0  1  Pkinase_Tyr    Protein tyrosine kinase
     0.0016   17.8   0.0     0.0039   16.6   0.0    1.5  1  Kdo            Lipopolysaccharide kinase (Kdo/WaaP) family
     0.0099   15.1   0.0      0.049   12.8   0.0    2.2  1  NB-ARC         NB-ARC domain
  ------ inclusion threshold ------
      0.025   14.6   0.1       0.15   12.1   0.0    2.3  2  SpoVT_C        Stage V sporulation protein T C-terminal, tran
       0.05   13.0   0.0        0.1   12.0   0.0    1.4  1  TniB           Bacterial TniB protein
       0.07   13.8   0.0        0.2   12.3   0.0    1.7  1  Phostensin     Phostensin PP1-binding and SH3-binding region
       0.12   11.6   0.0       0.36   10.1   0.0    1.8  2  Zeta_toxin     Zeta toxin
       0.15   12.7   0.0       0.38   11.4   0.0    1.7  1  GAF            GAF domain


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.8   0.1     2e-28   3.2e-25       7     176 ..    1887    2053 ..    1883    2060 .. 0.93

  Alignments for each domain:
  == domain 1  score: 88.8 bits;  conditional E-value: 2e-28
  Guanylate_cyc    7 devtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskegl 100 
                     +e+t+lF+dI gft++++  s+++ + ++n l +++   ++++ +  +k++Gd +++++  p       + ++  aL+m+++le ++ ++++++
     EFC39209.1 1887 REMTVLFSDIYGFTEIMEGLSAKDGFAFINLLLKSIAPPISRNSGFIDKFVGDGILALFIEP-------QGAVTAALEMISELEVFNSRNNTNV 1973
                     799********************************************************999.......888999******************* PP

  Guanylate_cyc  101 kvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgka..gkiqvseetyellk.eeqfeltergevevkGkgkl 176 
                     k++vG+h+G v +g+iG +++ + +v+++tvn+Asr es++ +  ++i v++ +++  +  +++  te+g++ +kGk+  
     EFC39209.1 1974 KLGVGLHHGIVQLGTIGyEQRLDATVISDTVNTASRCESLTRTfhSHILVTKPVMDAVTvPHSVISTELGKFMLKGKHIP 2053
                     *****************99*********************9863378999*********8899999999*******8654 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.8   0.0   2.6e-27   4.3e-24       2     170 .]     652     848 ..     651     848 .. 0.89

  Alignments for each domain:
  == domain 1  score: 85.8 bits;  conditional E-value: 2.6e-27
      AAA_16   2 lvGReeeleqLlsale.rvrsgrpelvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawre 99 
                 ++GRee  ++L+  le +  s++p +vll G+sG+GKs +v+e++++ +++ + f+++k+dq+ +++py+a+++++ + +++ ++l e+es    ++r 
  EFC39209.1 652 VYGREEIFKKLELKLEnMMESSEPTIVLLGGYSGIGKSCIVKEFRTRSKTA-IQFFEAKYDQH-MNVPYYAIISIC-K-QIIGDVLGESES-VIKDFRF 745
                 69*********9999978888888*********************999999.**********9.************.8.9********888.99***** PP

      AAA_16 100 kleeala..........................avpelagaea...srllellkrll.allsrderplvlvlDdlqwadeaslqllaaLlrlles.k.p 166
                 +l + ++                           +p++ ++     + + + + +l+ ++++ +++ l ++lDdlqw d++s++ll+++l +++    p
  EFC39209.1 746 QLGTLINsdqlemlsdaipdmsylfttnatkkhTSPSMGDQNGermKLFSQGIIHLFsVYTHLKKKRLCIFLDDLQWTDFDSMKLLKEILGTGSCdTvP 844
                 9*99999**9999999999999999999998874444444433667999********8888888888*********************99997766457 PP

      AAA_16 167 llvv 170
                 ll++
  EFC39209.1 845 LLII 848
                 7776 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.7   0.0   1.1e-24   1.8e-21      98     253 ..     436     607 ..     329     614 .. 0.79

  Alignments for each domain:
  == domain 1  score: 76.7 bits;  conditional E-value: 1.1e-24
                 H.....HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTEEEE-SGTTSEESSSSCS...BCTTTSCGGGS-HHHHTT..SCBSHHHHHHHHHH CS
     Pkinase  98 e.....eakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelesssk...ltsfvgtseYlAPEvlke..neyskkvDvWslGv 185
                 +         +a +i+ +++ lH+ +++H D+ peNi+++  k +++++DFG ++ l  +++   +++++g++ Y+APE  ++  ++++ ++D++slG 
  EFC39209.1 436 NitileSNLTLAISICMSVAQLHHSRVCHADIRPENIIVEgPKCNIRLIDFGKSTFLPLEHPflyTDKIIGSQMYCAPEATGKipKPIGFHTDIYSLGF 534
                 14443222356778999***********************89999**************9999*9999*************5544999*********** PP

                 HHHHHHHSS-STTTSSHHHHHHHHHHT.HHHHHHHCTSHH...HHHTTS....-HHHHHHHHHHT-SSGCCST CS
     Pkinase 186 ilyelltgkppfsgekgkekvekeldq.lekilkilgetkeklpeasei....seeakdllkkllkkdpkkRl 253
                 +l+el+++++pf + ++ + v ++l+q  e++++ l   ++ ++++ ++     + + +l++k ++k  +kR+
  EFC39209.1 535 VLFELFSKEHPFTKFRTLDFVFQHLTQqPESLFQNLARRSFISANEGNLftaaTKAISRLITKAIQKSIEKRY 607
                 *************988888777777774666677766444444444444555588888999999999888885 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.3   0.0   1.6e-14   2.5e-11      60     216 ..     369     556 ..     344     577 .. 0.85

  Alignments for each domain:
  == domain 1  score: 43.3 bits;  conditional E-value: 1.6e-14
                  BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT...............................CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEE CS
  Pkinase_Tyr  60 hpnivkllgvctkeepllivteyvkgGdLlkfLrkk...............................ekekltlkdllsfalqvAkGmeyLeskklvH 126
                  ++ iv+  +  +  +  ++v e+++  +L++f+ ++                               +++ + l++ l +a+ ++  ++ L++ ++ H
   EFC39209.1 369 QQVIVSTKAYLS--DYFILVREFIDCVSLRSFIDRSktyaraepitdenfetltddtvtllneeqrvKENITILESNLTLAISICMSVAQLHHSRVCH 464
                  445555555444..7899****************999***************************9966666677889********************* PP

                  ST-SGGGEEEEETT.EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..EEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHH CS
  Pkinase_Tyr 127 rdlaarNvLlsenk.vvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwEiftlgespypglkneevle 216
                   d++  N++++  k  +++ DfG +  +  ++    +++   +  ++apE+  +    +  ++D++s G +l+E+f+  e+p++++++ +++ 
   EFC39209.1 465 ADIRPENIIVEGPKcNIRLIDFGKSTFLPLEHPFLYTDKIIGSQMYCAPEATGKIPkpIGFHTDIYSLGFVLFELFS-KEHPFTKFRTLDFVF 556
                  ***********97758************88888888999999*********9986556999****************.899999996666543 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   2.4e-06    0.0039     126     169 ..     449     489 ..     430     491 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 2.4e-06
         Kdo 126 avgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldka 169
                  +   +a+lh   v+Had+ + ni ++  +    +i liD+ k+
  EFC39209.1 449 SICMSVAQLHHSRVCHADIRPENIIVEGPK---CNIRLIDFGKS 489
                 577889*********************998...9*******998 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.8   0.0     3e-05     0.049      10     115 ..     667     824 ..     655     957 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 3e-05
                 HHHHCTTTSCSEEEEEEESTTSSHHHHHHHHCCSHCCCCC....CBTEEEEE............................................... CS
      NB-ARC  10 ekLlekdelqslvvalvGmgGvGKttlakqilnksdeveg....rFdsvawv............................................... 57 
                 e+++e+ e+   +v l G  G+GK+ ++k+    s++ ++    ++d ++ v                                               
  EFC39209.1 667 ENMMESSEPT--IVLLGGYSGIGKSCIVKEFRTRSKTAIQffeaKYDQHMNVpyyaiisickqiigdvlgesesvikdfrfqlgtlinsdqlemlsdai 763
                 4556666666..******************998877654422238888898899999999999999999999999999999999888888888888888 PP

                 .EEESXXHHHHHHHXXHHHHHCCCTTS.SSS-STTSHHHHHHHHCCCTTEEEEEEEE.-SH CS
      NB-ARC  58 .vvsktdkseeiletilkeLslseddl.eekeeveslkrklvrlLltkrfllvlDDV.wee 115
                   +s  ++ +   ++    +++++ ++ + ++++      ++  L++kr  + lDD  w+ 
  EFC39209.1 764 pDMSYLFTTNATKKHTSPSMGDQNGERmKLFSQGIIHLFSVYTHLKKKRLCIFLDDLqWTD 824
                 8777777777777777777777766541445666657788889999999999999974544 PP

>> SpoVT_C  Stage V sporulation protein T C-terminal, transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       2.5   4.1e+03      11      58 ..     564     608 ..     559     628 .. 0.68
   2 ?   12.1   0.0   9.1e-05      0.15      50     117 ..    1778    1841 ..    1762    1844 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.5
     SpoVT_C  11 eslaetlghivlitDrdqiiavagaskkellekeiskeleklmeerkt 58 
                 esl++ l +  +i+ ++  + +a +   + + + i+k+++k +e+r  
  EFC39209.1 564 ESLFQNLARRSFISANEGNLFTAAT---KAISRLITKAIQKSIEKRYL 608
                 6777777777777776666666633...34677777777777777755 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 9.1e-05
     SpoVT_C   50 eklmeerktvlakkeekklvveeekeeysaqviaPIiaeGdviGaVillskeekkklgelekklaeta 117 
                   +  e++  ++ +++e ++v    k+ + + + +PI+ +  viG++ l +ke+k+ ++  +++la+ +
  EFC39209.1 1778 RSRTEQQLVWNDNEKEYYFV----KNVVASALSIPIMKKKTVIGCIYLENKETKDVFTTEKINLAKLI 1841
                  33333333332222222222....236788999******************************99987 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   6.3e-05       0.1      17      62 ..     656     702 ..     647     723 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 6.3e-05
        TniB  17 keilerLe.eLleypkrkrmpnlllvGdsnnGKtmivekFarlhppe 62 
                 +ei+++Le +L ++ +++++  +ll G s +GK+ iv++F+ + + +
  EFC39209.1 656 EEIFKKLElKLENMMESSEPTIVLLGGYSGIGKSCIVKEFRTRSKTA 702
                 688999973677778899999999999**************877654 PP

>> Phostensin  Phostensin PP1-binding and SH3-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   0.00012       0.2      92     124 ..     677     709 ..     661     718 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00012
  Phostensin  92 IeViGGYlaLekscLvkagssrKklKisFneks 124
                 I  +GGY  + ksc+vk   +r k+ i+F e +
  EFC39209.1 677 IVLLGGYSGIGKSCIVKEFRTRSKTAIQFFEAK 709
                 7889*************************8876 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.9     3e+03      77      96 ..     588     607 ..     581     611 .. 0.85
   2 ?   10.1   0.0   0.00022      0.36      10      40 ..     669     699 ..     660     712 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.9
  Zeta_toxin  77 qkdaselvekllqeaiengy 96 
                  k++s+l +k++q+ ie++y
  EFC39209.1 588 TKAISRLITKAIQKSIEKRY 607
                 67899*************99 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00022
  Zeta_toxin  10 ypsqerPklillgGqpGAGKselaellkdel 40 
                 + ++++P+++llgG +G GKs + ++++++ 
  EFC39209.1 669 MMESSEPTIVLLGGYSGIGKSCIVKEFRTRS 699
                 66889*******************9999886 PP

>> GAF  GAF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00023      0.38      58     123 ..    1781    1839 ..    1703    1844 .. 0.55

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00023
                  HSSSEEESTGGTSTTHHTTHHHHHHHHTTESEEEEEEEEETTEEEEEEEEEE..SSSCSHHHHHHHHH CS
         GAF   58 tgqplvipdstpdprfaqynrrdllenmgirsslvvPlvndgelwGllvlhn..psppftreelellq 123 
                  t q lv +d  ++  f +           + s+l++P++ +  ++G ++l n  +++ ft+e ++l++
  EFC39209.1 1781 TEQQLVWNDNEKEYYFVK---------NVVASALSIPIMKKKTVIGCIYLENkeTKDVFTTEKINLAK 1839
                  344444444223333333.........455699*******************765559*999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2148 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1003  (0.0559429); expected 358.6 (0.02)
Passed bias filter:                      577  (0.0321825); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 1.23u 0.35s 00:00:01.58 Elapsed: 00:00:00.55
# Mc/sec: 11693.88
//
Query:       EFC39210.1  [L=818]
Description: LRR domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-32  110.3  46.9    1.2e-06   28.1   4.5    7.1  7  LRR_8     Leucine rich repeat
    3.1e-26   91.0  59.0    1.1e-05   25.7   6.3    9.5 11  LRR_4     Leucine Rich repeats (2 copies)
    4.6e-05   23.4  49.2       0.94   10.3   1.8   12.6 11  LRR_1     Leucine Rich Repeat
    0.00011   21.8  20.7      0.014   14.9   1.1    4.3  5  LRR_9     Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   4.0   1.5e-09   6.9e-06       3      38 ..     360     395 ..     358     398 .. 0.85
   2 !   26.1   0.6   1.2e-09   5.4e-06      16      61 .]     399     443 ..     395     443 .. 0.96
   3 !   28.1   4.5   2.7e-10   1.2e-06       3      61 .]     443     499 ..     442     499 .. 0.89
   4 !   12.1   3.2   2.8e-05      0.13      22      60 ..     508     547 ..     500     547 .. 0.86
   5 !   15.2   4.7     3e-06     0.014       2      58 ..     512     569 ..     511     569 .. 0.90
   6 !   23.8   2.3   6.3e-09   2.8e-05       2      59 ..     561     616 ..     560     617 .. 0.96
   7 !   17.3   0.0   6.6e-07    0.0029      24      61 .]     642     678 ..     634     678 .. 0.92

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 1.5e-09
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                  t+L L+nN++ sld + F+++ +L++L+Ls+N+++
  EFC39210.1 360 CTELKLNNNKIRSLDSKHFTNFAHLTELNLSSNRMS 395
                 578999999999999999999999999999999876 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 1.2e-09
                 E-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  16 lddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 l+ + F+++++L+ L+L +  l+tl p+++  L  L++L Ls N+L
  EFC39210.1 399 LPEDIFSHMPHLQRLSLDYMGLKTL-PKSINKLVELTYLSLSFNKL 443
                 8899*********************.9*****************98 PP

  == domain 3  score: 28.1 bits;  conditional E-value: 2.7e-10
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L++ +L + +  +l+d + k l+nL++L+Ls N+l+++ p  + +++sL++L Ls+Nr+
  EFC39210.1 443 LNTFNLLHGKDRHLNDFWPK-LTNLEYLNLSGNRLNRF-PSEICNCKSLEFLSLSNNRI 499
                 55666666666789999999.*****************.9*****************98 PP

  == domain 4  score: 12.1 bits;  conditional E-value: 2.8e-05
                 TT-TT--EEE--SS---GGG.GGGGTT--S-.EEE--SS- CS
       LRR_8  22 kglsnLkvLdLsnNllttls.pgafsgLpsLrsLdLsgNr 60 
                 ++l++L +L L+ N+ t l+ ++ ++ L++L++L L +N+
  EFC39210.1 508 ENLKKLAILFLNGNKVTALDiNRNLEFLENLTHLELGHNP 547
                 579**************9654799**************95 PP

  == domain 5  score: 15.2 bits;  conditional E-value: 3e-06
                 T-SEEE-TTS--SEE-.TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltsld.deaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsg 58 
                 +L +L L+ N+ t+ld     + l+nL++L+L++N +++++ p    +L++L+sL Ls+
  EFC39210.1 512 KLAILFLNGNKVTALDiNRNLEFLENLTHLELGHNpNIHVV-PPPVYNLTKLESLCLSH 569
                 7999********99994457777************999999.78999********9998 PP

  == domain 6  score: 23.8 bits;  conditional E-value: 6.3e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +L+sL Ls+  +++l+d+  k l+nL++LdL   +lt l p+ +s+L +Lr Ld++++
  EFC39210.1 561 KLESLCLSHLTISHLSDDIGK-LRNLTHLDLYGSKLTGL-PKGISQLINLRNLDMRYC 616
                 79*******************.*****************.9**************987 PP

  == domain 7  score: 17.3 bits;  conditional E-value: 6.6e-07
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +++L+ L+Ls+  ++++ p+ +s+L sL+ L +++++L
  EFC39210.1 642 MKSLTRLSLSYTMIESI-PEDISSLQSLQALLVNDCPL 678
                 89***************.9*************999876 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       2.3     1e+04      19      29 ..     212     222 ..     206     233 .. 0.69
   2 ?   -1.8   0.0       1.1   4.8e+03      24      33 ..     310     321 ..     298     327 .. 0.66
   3 !   22.2   3.9     3e-08   0.00014       2      33 ..     359     392 ..     358     403 .. 0.91
   4 !   12.9   2.9   2.6e-05      0.12       1      39 [.     408     446 ..     408     451 .. 0.86
   5 !   18.2   5.8   5.6e-07    0.0025       2      39 ..     432     479 ..     431     485 .. 0.84
   6 !   25.7   6.3   2.4e-09   1.1e-05       1      39 [.     464     503 ..     464     512 .. 0.79
   7 !   20.8   4.2   8.4e-08   0.00038       1      40 [.     487     527 ..     487     533 .. 0.87
   8 !   19.9   0.6   1.6e-07   0.00072       2      39 ..     537     572 ..     536     581 .. 0.84
   9 !   18.4   0.1   4.9e-07    0.0022       2      36 ..     584     619 ..     583     625 .. 0.85
  10 !   14.7   0.2   6.9e-06     0.031       1      42 [.     643     685 ..     643     687 .. 0.86
  11 !    6.3   0.2    0.0031        14       1      33 [.     666     699 ..     666     705 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.3
                 HHH-TT--EEE CS
       LRR_4  19 leklpnLkeLd 29 
                 +e ++nL +L+
  EFC39210.1 212 IEENKNLSYLY 222
                 34589999997 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.1
                 T--EEE-...-S CS
       LRR_4  24 nLkeLdL..sgN 33 
                 n ++L++  ++N
  EFC39210.1 310 NIRHLYCdyWSN 321
                 677888755555 PP

  == domain 3  score: 22.2 bits;  conditional E-value: 3e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 n ++L L+nN+++++++  + ++ +L+eL+Ls+N
  EFC39210.1 359 NCTELKLNNNKIRSLDSkhFTNFAHLTELNLSSN 392
                 89***************99999*********999 PP

  == domain 4  score: 12.9 bits;  conditional E-value: 2.6e-05
                 SS--EEE--SS---E-S-.HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl.leklpnLkeLdLsgNnlitdl 39 
                 p+L+ L+L    l+++p  ++kl  L++L+Ls+N +++++
  EFC39210.1 408 PHLQRLSLDYMGLKTLPKsINKLVELTYLSLSFN-KLNTF 446
                 78*******999******7778*********888.66555 PP

  == domain 5  score: 18.2 bits;  conditional E-value: 5.6e-07
                 S--EEE--SS---E-S-HH...........H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplle...........klpnLkeLdLsgNnlitdl 39 
                  L++L+Ls N+l +++ll            kl+nL++L+LsgN +++++
  EFC39210.1 432 ELTYLSLSFNKLNTFNLLHgkdrhlndfwpKLTNLEYLNLSGN-RLNRF 479
                 69***************66666677799999************.66554 PP

  == domain 6  score: 25.7 bits;  conditional E-value: 2.4e-09
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 +nLe+L+Ls+N+l  +p+  + ++++L+ L+Ls+N  i+ +
  EFC39210.1 464 TNLEYLNLSGNRLNRFPSeiC-NCKSLEFLSLSNNRIINEI 503
                 7*****************733.6*********888544555 PP

  == domain 7  score: 20.8 bits;  conditional E-value: 8.4e-08
                 SS--EEE--SS---.E-S-.HHH-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqlt.dipl.leklpnLkeLdLsgNnlitdld 40 
                 ++Le+L+LsnN++  +ip  +e+l++L  L L+gN ++t ld
  EFC39210.1 487 KSLEFLSLSNNRIInEIPKeIENLKKLAILFLNGN-KVTALD 527
                 68**********88899998889*********999.777775 PP

  == domain 8  score: 19.9 bits;  conditional E-value: 1.6e-07
                 S--EEE--SS.---E-S-HH.H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnN.qltdiplle.klpnLkeLdLsgNnlitdl 39 
                 nL++L L++N ++  +p++  +l++L++L Ls+     ++
  EFC39210.1 537 NLTHLELGHNpNIHVVPPPVyNLTKLESLCLSHL----TI 572
                 9*********9*******8856*******99874....43 PP

  == domain 9  score: 18.4 bits;  conditional E-value: 4.9e-07
                 S--EEE--SS---E-S-.HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpnLkeLdLsgNnli 36 
                 nL++LdL + +lt +p  +++l nL+ Ld+  +  i
  EFC39210.1 584 NLTHLDLYGSKLTGLPKgISQLINLRNLDMRYCRGI 619
                 9*******88*******8778********9666555 PP

  == domain 10  score: 14.7 bits;  conditional E-value: 6.9e-06
                 SS--EEE--SS---E-S-.HHH-TT--EEE-..-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqltdipl.leklpnLkeLdL.sgNnlitdldeL 42 
                 ++L+ L+Ls +++ +ip  +++l +L+ L L ++++l++ + ++
  EFC39210.1 643 KSLTRLSLSYTMIESIPEdISSLQSLQAL-LvNDCPLLEEIKGI 685
                 68****************7667******9.86889888988765 PP

  == domain 11  score: 6.3 bits;  conditional E-value: 0.0031
                 SS--EEE--SS.---E-S-HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnN.qltdiplleklpnLkeLdLsgN 33 
                 ++L+ L  +++  l +i ++ kl nL e+d+s++
  EFC39210.1 666 QSLQALLVNDCpLLEEIKGIDKLVNLVEFDISRC 699
                 5899999***96677****999*********997 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0         4   1.8e+04       1       7 [.     310     316 ..     310     335 .. 0.61
   2 ?    1.9   0.6      0.12   5.4e+02       3      23 .]     361     381 ..     359     381 .. 0.87
   3 ?    4.0   0.2     0.025   1.1e+02       1      12 [.     383     394 ..     383     418 .. 0.76
   4 ?    1.1   0.4      0.22   9.8e+02       2      12 ..     433     443 ..     432     459 .. 0.76
   5 !   10.3   1.8   0.00021      0.94       1      20 [.     465     483 ..     465     486 .. 0.76
   6 !    8.1   0.8    0.0011       4.9       1      23 []     488     510 ..     488     510 .. 0.94
   7 !    9.1   0.7   0.00053       2.4       1      19 [.     537     555 ..     537     579 .. 0.78
   8 !    6.6   0.0    0.0035        16       1      17 [.     584     600 ..     584     604 .. 0.89
   9 ?    3.8   0.0     0.028   1.2e+02       1      13 [.     607     619 ..     607     634 .. 0.81
  10 ?    0.2   0.2      0.44     2e+03       1      12 [.     667     678 ..     644     688 .. 0.62
  11 ?    3.2   0.0     0.043   1.9e+02       1      20 [.     690     709 ..     690     712 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4
       LRR_1   1 nLrhLdL 7  
                 n rhL+ 
  EFC39210.1 310 NIRHLYC 316
                 6788875 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.12
       LRR_1   3 rhLdLsnnpllglppnsfqnL 23 
                 ++L L+nn + +l + +f n+
  EFC39210.1 361 TELKLNNNKIRSLDSKHFTNF 381
                 6899******99999999875 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.025
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L+Ls+n+ 
  EFC39210.1 383 HLTELNLSSNRM 394
                 69********95 PP

  == domain 4  score: 1.1 bits;  conditional E-value: 0.22
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L Ls n l
  EFC39210.1 433 LTYLSLSFNKL 443
                 89*******98 PP

  == domain 5  score: 10.3 bits;  conditional E-value: 0.00021
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL++L+Ls+n+l ++p + +
  EFC39210.1 465 NLEYLNLSGNRLNRFP-SEI 483
                 8***********5555.444 PP

  == domain 6  score: 8.1 bits;  conditional E-value: 0.0011
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L+ L Lsnn++++ +p  ++nL
  EFC39210.1 488 SLEFLSLSNNRIINEIPKEIENL 510
                 69****************99997 PP

  == domain 7  score: 9.1 bits;  conditional E-value: 0.00053
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL+hL L++np+++  p+ 
  EFC39210.1 537 NLTHLELGHNPNIHVVPPP 555
                 8**********96665554 PP

  == domain 8  score: 6.6 bits;  conditional E-value: 0.0035
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 nL+hLdL +  l+glp+
  EFC39210.1 584 NLTHLDLYGSKLTGLPK 600
                 8***********99986 PP

  == domain 9  score: 3.8 bits;  conditional E-value: 0.028
       LRR_1   1 nLrhLdLsnnpll 13 
                 nLr Ld+++++++
  EFC39210.1 607 NLRNLDMRYCRGI 619
                 8*********974 PP

  == domain 10  score: 0.2 bits;  conditional E-value: 0.44
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+ L ++++pl
  EFC39210.1 667 SLQALLVNDCPL 678
                 355555666666 PP

  == domain 11  score: 3.2 bits;  conditional E-value: 0.043
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL + d+s+++ l  pp++ 
  EFC39210.1 690 NLVEFDISRCISLVEPPSDV 709
                 8999*******998888765 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   1.1     3e-06     0.014      47     124 ..     363     442 ..     359     452 .. 0.84
   2 !    7.4   2.6   0.00061       2.7      61     126 ..     461     524 ..     440     528 .. 0.56
   3 !   11.2   4.1   4.2e-05      0.19      47     125 ..     469     548 ..     461     554 .. 0.82
   4 ?    2.0   0.1     0.028   1.3e+02      63     116 ..     559     612 ..     553     616 .. 0.81
   5 ?    2.0   0.1     0.028   1.3e+02      63     123 ..     642     705 ..     635     722 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 3e-06
       LRR_9  47 idlsdndirkldg..fPllkrlktlllnnnriv..riaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                 ++l++n+ir ld+  f  +  l  l l++nr+   r+ e++   +P+l+ l l    l+ l +   + +l +l++lsl  n 
  EFC39210.1 363 LKLNNNKIRSLDSkhFTNFAHLTELNLSSNRMSkaRLPEDIFSHMPHLQRLSLDYMGLKTLPK--SINKLVELTYLSLSFNK 442
                 5799*******964488899***********9622678*****************99**9987..77788888888886665 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.00061
       LRR_9  61 PllkrlktlllnnnrivriaegleevlPnleelvltnne.lqeladldPlaslkklellsllknpvt 126
                 P l  l+ l l+ nr+ r   ++ ++  +le l l+nn+ ++e+   + + +lkkl +l l  n vt
  EFC39210.1 461 PKLTNLEYLNLSGNRLNRFPSEICNC-KSLEFLSLSNNRiINEIP--KEIENLKKLAILFLNGNKVT 524
                 66666666666666666666666543.456666666666233333..24555666666666555555 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 4.2e-05
       LRR_9  47 idlsdndirkl.dgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 ++ls n ++++  ++   k l+ l+l+nnri++  ++  e l +l  l l++n+++ l     l  l++l+ l l +np 
  EFC39210.1 469 LNLSGNRLNRFpSEICNCKSLEFLSLSNNRIINEIPKEIENLKKLAILFLNGNKVTALDINRNLEFLENLTHLELGHNPN 548
                 566666666652356678999*********998777777889****************88889999*******9999985 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.028
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqelad.ldPlaslkkle 116
                 l +l++l l+   i ++++++++ l nl++l l +++l+ l + +  l++l++l+
  EFC39210.1 559 LTKLESLCLSHLTISHLSDDIGK-LRNLTHLDLYGSKLTGLPKgISQLINLRNLD 612
                 67889999999999999999986.7899999999999999864388888888876 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.028
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnne.lqeladldPlaslkkl...ellsllkn 123
                 +k l  l+l+   i  i e+++ +l +l++l++++   l+e+  +d l++l ++   +++sl++ 
  EFC39210.1 642 MKSLTRLSLSYTMIESIPEDIS-SLQSLQALLVNDCPlLEEIKGIDKLVNLVEFdisRCISLVEP 705
                 6778888999999999999996.578999999888755788888888877766511156777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (818 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       762  (0.042501); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.49
# Mc/sec: 4977.89
//
Query:       EFC39211.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.039   13.8   3.4      0.072   13.0   3.4    1.5  1  AT_hook   AT hook motif


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   3.4     4e-06     0.072       1      11 [.     271     281 ..     271     283 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 4e-06
     AT_hook   1 kRkRGRPrKaa 11 
                 k+kRGRP+K +
  EFC39211.1 271 KKKRGRPPKVN 281
                 8********76 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1255  (0.0699983); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.48
# Mc/sec: 2096.29
//
Query:       EFC39212.1  [L=629]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-22   80.0   0.0    3.8e-22   78.5   0.0    1.6  1  Pyridoxal_deC  Pyridoxal-dependent decarboxylase conserved do


Domain annotation for each model (and alignments):
>> Pyridoxal_deC  Pyridoxal-dependent decarboxylase conserved domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.5   0.0   2.1e-26   3.8e-22      11     371 ..     108     490 ..     101     494 .. 0.86

  Alignments for each domain:
  == domain 1  score: 78.5 bits;  conditional E-value: 2.1e-26
                    SHHSSHH.HHHHHHHHHHCTGGGS--TTSTTBHCSSH....HHHHHHHHHHHHHT-BTSSTTTSHHHHHHHHHHHHHHHHHTT--GGGTCCT-EEE CS
  Pyridoxal_deC  11 aapekaesleqilediekilapgvttwhspefhkllpagnslisllgdlLadainkngftweesPaltelevvvldwlaellglpeeflekegggv 106
                    ++p+  ++ +++++ +      gv    sp + + +   ++++++++ l a+  n  +++ e s  +++ e+ ++ ++a+l+g+     +k+++gv
     EFC39212.1 108 EIPQSCKTPQEVISKVSSYF-NGVLDNASPIMLENVHPPSNIPAIISTLFASLYNVGMVQDEFSWNVVLTEIETIGMMAKLIGWD----AKKANGV 198
                    55666666666666666654.4556666688888888899********************************************9....44588** PP

                    EESSHHHHHHHHHHHHHHHHHHHHHHHTTTS.HHHHHCCEEEEEETTS-HHHHHHHHHHT-E...EEEE--BTTTBB-HHHHHHHHHHHHCTT.EE CS
  Pyridoxal_deC 107 lqvgssestllallAartkvikemkekgkelkeaeildklvlytsdqahssvekaalvlgvk...lrvipldengklrgaalekaieedkekGlip 199
                    ++ g++   l+++  a t      ++ g++++ + i +   ++ s+  h++  ++   lg++   +  i ++e+ ++  ++l  ++ +  ++G  +
     EFC39212.1 199 FTFGGTGNELYGIKVALT------RALGMDYRYKGIRENVKIFVSEIGHYCKFNVTDWLGIGmdnVVPISITEDNSMNYDDLYDKLSKSVKNGEKI 288
                    ***********9854444......3557777777899************************944444567889999******************** PP

                    EEEEEEBS-TTT-BB--HHHHHHHHHH...............................CT-EEEEE-TTGGGGGGSGGGGG...GGTTGGGESEEE CS
  Pyridoxal_deC 200 ffvvatlGttvlgaFddlkelgdicek...............................ydlwlHvDAAyaGsaficpeirh...llkgieradSit 261
                      +v t G+t   + dd++e+ +i ++                               ++ +l + A y       p i+    +++++e+ad + 
     EFC39212.1 289 AAIVSTCGSTDPFSVDDVSEIVKIRDRiveennldykpfvyadsvigwpwlffktynfEENPLQIEADYVL-----PAIKSvlsKMEKLELADAVG 379
                    ************************999999*************************999999*******976.....444444449*********** PP

                    EECCCCTS--SS-EEEEESSCCGCHHHH-EE...ECCCT.TTTTTSEECCCGSSSSSGHHTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  Pyridoxal_deC 262 vnphKlllvlldcsalivkdkealqqalqle...aeYLehedsdvaadlgtkaiplsrrvrilklwfvlralGveglqnqirksvelakyleklir 354
                    +  hK +  +  cs++++kd ++ ++ l+     a+YL +  s   +  gt+++++sr    l  +  +  +Gveg+q  i + + + ++l+ ++ 
     EFC39212.1 380 LDFHKTGFCHYICSCVMFKDGKEFEENLSRPkdfAQYLYNF-S--VYKPGTYTLECSRAASCLAAFSTIHLFGVEGYQSLIAHLISVQHALRTNLT 472
                    ********************999998886541225677622.2..5899*********************************************99 PP

                    TTTT.EEECSTTBSSEEE CS
  Pyridoxal_deC 355 kder.feivaevelglVc 371
                    ++ +   iv++   g V+
     EFC39212.1 473 EQMKnVAIVNDLDNGFVS 490
                    998879999988777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (629 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1001  (0.0558313); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.47
# Mc/sec: 4045.21
//
Query:       EFC39213.1  [L=786]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (786 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1049  (0.0585086); expected 358.6 (0.02)
Passed bias filter:                      451  (0.0251548); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.29s 00:00:01.00 Elapsed: 00:00:00.46
# Mc/sec: 5105.14
//
Query:       EFC39214.1  [L=172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       344  (0.0191868); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1051.18
//
Query:       EFC39215.1  [L=204]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.001   19.3   0.1     0.0026   18.0   0.1    1.8  1  LRRNT_2   Leucine rich repeat N-terminal domain
     0.0099   15.6   0.2       0.14   11.9   0.2    2.1  2  LRR_8     Leucine rich repeat


Domain annotation for each model (and alignments):
>> LRRNT_2  Leucine rich repeat N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.1   2.9e-07    0.0026      23      40 ..      44      65 ..      22      66 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 2.9e-07
                TTGT....CCCCTGGGSTTEEE CS
     LRRNT_2 23 ssWn....ssstdpCsWtGVtC 40
                + Wn     + td+C+W GV+C
  EFC39215.1 44 EGWNtmgtRDETDYCTWYGVEC 65
                6787899999************ PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.9   0.2   1.6e-05      0.14       8      60 ..      78     129 ..      74     130 .. 0.80
   2 !    4.2   0.0    0.0042        37      27      45 ..     120     138 ..     115     141 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.6e-05
                 -TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   8 LsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 ++nN   sl+ +   gl++L+v+++  N l+   p+   +   ++ +dLs+N+
  EFC39215.1  78 INNNLTGSLPTGIVDGLQSLMVFEIALNGLRGEIPEEYGHT-TITDIDLSYNQ 129
                 45555999********************9998556766665.88888888887 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.0042
                 --EEE--SS---GGGGGGG CS
       LRR_8  27 LkvLdLsnNllttlspgaf 45 
                  + +dLs+N+ + + p+ +
  EFC39215.1 120 ITDIDLSYNQFEGILPHGI 138
                 56799****9999988866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (204 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       686  (0.038262); expected 358.6 (0.02)
Passed bias filter:                      260  (0.0145016); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1254.79
//
Query:       EFC39216.1  [L=726]
Description: hypothetical protein NAEGRDRAFT_81361 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-07   31.7  16.2    1.2e-07   31.7  16.2    1.7  2  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
     0.0067   17.1   7.1      0.018   15.8   7.1    1.6  1  IMUP      Immortalisation up-regulated protein
  ------ inclusion threshold ------
       0.71    9.4  10.1        1.4    8.5  10.1    1.4  1  SR-25     Nuclear RNA-splicing-associated protein
        2.3    9.0  11.8        3.1    8.6  10.1    2.1  1  RBR       RNA binding Region


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7  16.2   2.8e-11   1.2e-07       2      39 ..      95     131 ..      94     132 .. 0.95
   2 ?   -3.6   0.3         3   1.3e+04      20      25 ..     390     395 ..     389     397 .. 0.75

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 2.8e-11
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 aC +Crk ++KCd+k P+Cs+C ++++eC  y+ ++k+
  EFC39216.1  95 ACLQCRKLHRKCDKKYPSCSECLERGKECC-YRTPKKK 131
                 9*****************************.9999887 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 3
                 -HHHHH CS
     Zn_clus  20 CsnCkk 25 
                 Cs C k
  EFC39216.1 390 CSLCSK 395
                 888887 PP

>> IMUP  Immortalisation up-regulated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   7.1   3.9e-06     0.018      25      72 ..     134     180 ..     122     194 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 3.9e-06
        IMUP  25 pkhsPkkvqGaseagaaekprhghgkssssdsssssssssdsdaeakp 72 
                  k s +k +  ++  ++ek +++    sss+sssssssssdsd++  p
  EFC39216.1 134 TKGSKNKPKP-TQPPLQEKVKKTLVVVSSSSSSSSSSSSSDSDNNLSP 180
                 4444444433.4556777888888889999999999*******98665 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  10.1   0.00031       1.4      23      80 ..     113     174 ..      98     207 .. 0.44

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00031
       SR-25  23 sskdssrsssasksqsrkassasekee....erskekkkkkrrrssssssssssssssssss 80 
                  s++ +r       + +k+ +++ +++    ++   ++k k++    sssssssssssss s
  EFC39216.1 113 CSECLERGKECCYRTPKKKGRTKGSKNkpkpTQPPLQEKVKKTLVVVSSSSSSSSSSSSSDS 174
                 33443343333333333333333322212222222222222222222222222222222222 PP

>> RBR  RNA binding Region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  10.1   0.00069       3.1      37      56 ..     126     145 ..     121     146 .. 0.93

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00069
         RBR  37 kipKKRGpKPGsKrKprvvq 56 
                 ++pKK+G+ +GsK Kp++ q
  EFC39216.1 126 RTPKKKGRTKGSKNKPKPTQ 145
                 89***************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (726 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       977  (0.0544927); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.36s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 4128.99
//
Query:       EFC39217.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0053   16.6   0.0     0.0053   16.6   0.0    1.7  2  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.014   15.3   0.4      0.045   13.6   0.4    1.8  1  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0     6e-07    0.0053      15      38 ..      81     103 ..      71     110 .. 0.85
   2 ?   -3.7   0.4       1.3   1.2e+04      31      42 ..     212     220 ..     212     221 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 6e-07
  F-box-like  15 yLppsdLlrlalVCrrWrrvaldt 38 
                 yL  +d++++++VC+ W++++ d+
  EFC39217.1  81 YLRWRDIVSCMRVCKEWKEII-DC 103
                 67778***************9.44 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.3
  F-box-like  31 WrrvaldtplLW 42 
                 W++++     LW
  EFC39217.1 212 WYSLT--S-PLW 220
                 99997..5.688 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.4     5e-06     0.045      22      38 ..      86     102 ..      85     104 .. 0.94

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 5e-06
                 HHHHHCTT-HHHHHHHT CS
       F-box  22 dllalrrVSkgwrilid 38 
                 d+++++rV+k w+ +id
  EFC39217.1  86 DIVSCMRVCKEWKEIID 102
                 9**************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       502  (0.0279993); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.34s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2756.50
//
Query:       EFC39218.1  [L=185]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-12   46.6   1.5    1.9e-06   27.5   1.0    3.3  3  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.0   1.8e-06     0.033      22      44 ..      55      77 ..      53      81 .. 0.92
   2 !   27.5   1.0   1.1e-10   1.9e-06       3      40 ..     112     149 ..     110     154 .. 0.90
   3 ?    1.3   0.0     0.017     3e+02      25      35 ..     159     169 ..     158     177 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.8e-06
     DUF4116 22 eLknDkeivlkAvkqngtalsya 44
                +L++D +++++ v++n+++l +a
  EFC39218.1 55 SLRQDQNFIMQMVEKNSYILGHA 77
                79*****************9887 PP

  == domain 2  score: 27.5 bits;  conditional E-value: 1.1e-10
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngta 40 
                 E +l++++ ++ ++ +lse LknD++i+l+++++ng+ 
  EFC39218.1 112 ERALKLIEEYCVNYVKLSETLKNDIDICLACLRNNGFY 149
                 56899*******************************64 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.017
     DUF4116  25 nDkeivlkAvk 35 
                 ++ke++ +Av+
  EFC39218.1 159 QNKELIERAVR 169
                 68888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (185 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1045  (0.0582855); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1081.51
//
Query:       EFC39219.1  [L=642]
Description: Sel1 domain protein repeat-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-56  186.6  25.4    3.2e-07   30.8   0.1   12.6 13  Sel1      Sel1 repeat
      0.003   17.4   0.2         35    4.4   0.0    5.3  4  TPR_10    Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.061   12.7   1.2       0.11   11.9   1.2    1.4  1  DUF4618   Domain of unknown function (DUF4618)
      0.069   13.2  10.2        6.7    7.0   0.1    7.2  9  TPR_7     Tetratricopeptide repeat
      0.074   13.4  15.2         12    6.2   0.4    7.4  8  TPR_12    Tetratricopeptide repeat
      0.076   13.3   8.5        2.3    8.5   0.2    4.5  4  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
       0.44   11.2  11.7        4.5    8.0   0.4    4.8  5  TPR_16    Tetratricopeptide repeat
       0.76    9.7  32.7        3.3    7.7   1.6    9.9 11  TPR_1     Tetratricopeptide repeat
        1.1    9.6  30.6        1.7    9.0   1.6    9.7 12  TPR_2     Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.5   2.9e+03       7      35 ..     182     210 ..     180     213 .. 0.55
   2 !    8.6   0.0    0.0016       3.2       3      37 ..     216     249 ..     215     250 .. 0.77
   3 !   18.9   0.0   9.2e-07    0.0018       1      37 [.     251     285 ..     251     286 .. 0.90
   4 !   23.8   0.0   2.6e-08   5.2e-05       3      38 .]     289     322 ..     287     322 .. 0.93
   5 !   26.5   0.2   3.6e-09   7.1e-06       6      38 .]     328     358 ..     325     358 .. 0.93
   6 !   30.8   0.1   1.6e-10   3.2e-07       1      38 []     359     394 ..     359     394 .. 0.95
   7 !   10.6   0.1   0.00037      0.73      21      38 .]     409     427 ..     396     427 .. 0.86
   8 !    6.7   0.2    0.0064        13       3      38 .]     430     463 ..     428     463 .. 0.86
   9 !   24.5   0.0   1.6e-08   3.2e-05       2      38 .]     465     500 ..     464     500 .. 0.90
  10 !   11.9   0.0   0.00014      0.28       3      38 .]     503     535 ..     501     535 .. 0.91
  11 ?   -1.1   0.1       1.8   3.5e+03      21      38 .]     550     567 ..     540     567 .. 0.83
  12 !   16.4   0.0   5.6e-06     0.011       7      34 ..     574     599 ..     568     600 .. 0.88
  13 !   14.2   0.0   2.7e-05     0.053       6      31 ..     609     632 ..     606     633 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.5
        Sel1   7 LGmfylylnGl.g.vpkDpekAiewyekAAe 35 
                 LG +y+++ G  + +    e A e+++kA +
  EFC39219.1 182 LG-VYYFEMGEiMkTT-HHEYASELFKKAVD 210
                 66.5556666633222.35556677777766 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0016
        Sel1   3 AmyrLGmfylylnGlgvpk.DpekAiewyekAAeqG 37 
                 Am+  G   +y+ G    +   e+A+ewy kA ++G
  EFC39219.1 216 AMFTIG--VMYDIGPLQFQgGGEEAMEWYLKALNNG 249
                 677777..555888766665689*********9887 PP

  == domain 3  score: 18.9 bits;  conditional E-value: 9.2e-07
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 a A+ +LG +y   +G  v+kD++k ie+y +A ++G
  EFC39219.1 251 AKAAVNLGVVY--REGIVVKKDISKTIEYYSMADRMG 285
                 6799****666..********************7776 PP

  == domain 4  score: 23.8 bits;  conditional E-value: 2.6e-08
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  m+ L   +ly++G gv+ D+++A+++++kA ++Gd
  EFC39219.1 289 GMFYLS--LLYFDGEGVEEDINRAMKLLKKAGSLGD 322
                 69****..777***********************97 PP

  == domain 5  score: 26.5 bits;  conditional E-value: 3.6e-09
        Sel1   6 rLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 rLG  ++yl+G   + ++ekA++++ kAA++G+
  EFC39219.1 328 RLG--EIYLEGHLFEVNKEKAFYYFNKAAKLGS 358
                 9**..999****8888***************96 PP

  == domain 6  score: 30.8 bits;  conditional E-value: 1.6e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a Am+ LG   +y +G  v++D ek +++y k+A++G+
  EFC39219.1 359 AKAMHHLG--VMYRTGEFVEQDNEKSFRYYLKSAKLGH 394
                 68******..777************************9 PP

  == domain 7  score: 10.6 bits;  conditional E-value: 0.00037
        Sel1  21 k.DpekAiewyekAAeqGd 38 
                 k D ++A++wy k+A +Gd
  EFC39219.1 409 KdDMDEAFKWYLKSALNGD 427
                 44799**********9997 PP

  == domain 8  score: 6.7 bits;  conditional E-value: 0.0064
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 A+   G   l+ nG+ v+++  +A+ +  +AA+ G+
  EFC39219.1 430 AALYAG--ALLANGKKVERNLPLALMLCDRAARSGN 463
                 666777..56699*99*****************997 PP

  == domain 9  score: 24.5 bits;  conditional E-value: 1.6e-08
        Sel1   2 eAmyrLGmfylylnGlg.vpkDpekAiewyekAAeqGd 38 
                 +A++++G   +y++G+  +p D+ kAi++ye AA++++
  EFC39219.1 465 HALCNVG--RIYEFGDEtIPVDIPKAIQYYENAASMDS 500
                 7999***..777****77999**************985 PP

  == domain 10  score: 11.9 bits;  conditional E-value: 0.00014
        Sel1   3 AmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 Am  LG ++  l G ++ +D ekA +++ +  e+Gd
  EFC39219.1 503 AMLSLG-VL--LSGNDIYRDMEKAKQYLLRGSELGD 535
                 899999.67..8999*******************97 PP

  == domain 11  score: -1.1 bits;  conditional E-value: 1.8
        Sel1  21 kDpekAiewyekAAeqGd 38 
                  D+e A+ w   A e Gd
  EFC39219.1 550 EDYENALLWINEAIEEGD 567
                 589999999999999886 PP

  == domain 12  score: 16.4 bits;  conditional E-value: 5.6e-06
        Sel1   7 LGmfylylnGlgvpkDpekAiewyekAA 34 
                 LG   +y +G+ vp D++kAie++e+A 
  EFC39219.1 574 LG--KWYKEGKAVPLDYSKAIELFERAS 599
                 99..888********************5 PP

  == domain 13  score: 14.2 bits;  conditional E-value: 2.7e-05
        Sel1   6 rLGmfylylnGlgvpkDpekAiewye 31 
                  L+  ++y nGlgv+k++ekA e+++
  EFC39219.1 609 ELA--EMYRNGLGVEKNEEKANELMQ 632
                 599..899*************99987 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.018        35       5      17 ..     179     191 ..     177     192 .. 0.91
   2 ?    3.3   0.0     0.041        83      13      30 ..     230     247 ..     229     247 .. 0.88
   3 ?   -0.3   0.0      0.54   1.1e+03       2      13 ..     251     262 ..     250     263 .. 0.83
   4 ?    1.9   0.0      0.11   2.2e+02       2      13 ..     359     370 ..     358     373 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.018
      TPR_10   5 lnNLanalrqrgr 17 
                 l+NL+++++++g+
  EFC39219.1 179 LSNLGVYYFEMGE 191
                 89*********97 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.041
      TPR_10  13 rqrgrydeAealleeala 30 
                 + +g ++eA++++ +al+
  EFC39219.1 230 QFQGGGEEAMEWYLKALN 247
                 67999***********96 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.54
      TPR_10   2 AsslnNLanalr 13 
                 A +  NL++++r
  EFC39219.1 251 AKAAVNLGVVYR 262
                 67888******8 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.11
      TPR_10   2 AsslnNLanalr 13 
                 A ++++L++++r
  EFC39219.1 359 AKAMHHLGVMYR 370
                 789********8 PP

>> DUF4618  Domain of unknown function (DUF4618)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   1.2   5.4e-05      0.11       7      92 ..      92     178 ..      88     205 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.4e-05
     DUF4618   7 sleelkkheaeLtklnkeLvkeIqdtedstakkvrklLqqyeklktvisileksskkqleqakaeLqeweekeekklek.Leqqleq 92 
                 +l+  kk + +  +ln eLv++I ++e+ + ++  +l +    +++  +il++  ++ l+++k e +++e+   +++ek Le++  q
  EFC39219.1  92 ALKSVKKLNFSQVSLNDELVRKIAQCENFANLQSLNLYNSEISVASFKAILKSTFANSLKKLKFEGKNMEKSNCEEIEKyLEENSGQ 178
                 566777777777899**************************************************9999998877776415555444 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0       0.3     6e+02       2      14 ..     179     191 ..     178     192 .. 0.92
   2 ?   -3.2   0.0       6.2   1.2e+04      16      26 ..     236     246 ..     236     249 .. 0.79
   3 ?   -2.5   0.0       3.6   7.2e+03       3      11 ..     255     263 ..     253     263 .. 0.84
   4 ?   -2.4   0.0       3.4   6.8e+03       1      10 [.     325     334 ..     325     335 .. 0.80
   5 ?   -1.8   0.0       2.1   4.2e+03       2      25 ..     362     389 ..     361     397 .. 0.74
   6 ?   -1.9   0.0       2.4   4.7e+03       1      10 [.     466     475 ..     466     475 .. 0.90
   7 ?    2.1   0.0      0.12   2.4e+02      17      29 ..     487     499 ..     484     512 .. 0.81
   8 ?    1.6   0.2      0.17   3.5e+02       3      19 ..     540     556 ..     532     570 .. 0.82
   9 ?    7.0   0.1    0.0034       6.7      14      25 ..     587     599 ..     587     625 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.3
       TPR_7   2 LlnLarlysrlGd 14 
                 L+nL++ y+++G+
  EFC39219.1 179 LSNLGVYYFEMGE 191
                 89********997 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 6.2
       TPR_7  16 eeAielyeqsL 26 
                 eeA e y ++L
  EFC39219.1 236 EEAMEWYLKAL 246
                 79999999944 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 3.6
       TPR_7   3 lnLarlysr 11 
                 +nL+++y++
  EFC39219.1 255 VNLGVVYRE 263
                 69*****85 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 3.4
       TPR_7   1 aLlnLarlys 10 
                 a+++L+++y 
  EFC39219.1 325 AFCRLGEIYL 334
                 6789999996 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 2.1
       TPR_7   2 LlnLarlysr....lGdyeeAielyeqs 25 
                  + L+++y+     ++d e+  ++y +s
  EFC39219.1 362 MHHLGVMYRTgefvEQDNEKSFRYYLKS 389
                 5789999988777777777777777775 PP

  == domain 6  score: -1.9 bits;  conditional E-value: 2.4
       TPR_7   1 aLlnLarlys 10 
                 aL+n +r+y+
  EFC39219.1 466 ALCNVGRIYE 475
                 79******95 PP

  == domain 7  score: 2.1 bits;  conditional E-value: 0.12
       TPR_7  17 eAielyeqsLalt 29 
                 +Ai++ye +  ++
  EFC39219.1 487 KAIQYYENAASMD 499
                 8******965554 PP

  == domain 8  score: 1.6 bits;  conditional E-value: 0.17
       TPR_7   3 lnLarlysrlGdyeeAi 19 
                 ++La+l+  l dye+A+
  EFC39219.1 540 FALAELFYLLEDYENAL 556
                 589999999*****997 PP

  == domain 9  score: 7.0 bits;  conditional E-value: 0.0034
       TPR_7  14 dyeeAielyeq.s 25 
                 dy++Aiel+e+ s
  EFC39219.1 587 DYSKAIELFERaS 599
                 8**********43 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0       0.5     1e+03      43      73 ..     181     210 ..     164     213 .. 0.67
   2 ?    2.2   0.0      0.11   2.3e+02      27      56 ..     236     262 ..     229     264 .. 0.70
   3 ?    0.3   0.0      0.43   8.6e+02      42      58 ..     356     371 ..     344     376 .. 0.72
   4 ?   -1.1   0.0       1.2   2.4e+03      46      58 ..     360     371 ..     358     392 .. 0.62
   5 ?    5.7   0.0    0.0088        17       3      30 ..     395     423 ..     393     437 .. 0.85
   6 ?   -2.2   0.0       2.6   5.2e+03      21      30 ..     487     496 ..     484     500 .. 0.59
   7 ?    6.2   0.4    0.0062        12      49      73 ..     540     564 ..     521     564 .. 0.84
   8 ?    0.9   0.1      0.28   5.7e+02      60      71 ..     587     598 ..     586     599 .. 0.74

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.5
      TPR_12  43 ltattlrnLgrlyralgryeeAlelleeala 73 
                 ++  +++ +g++   + ++e A el+++a++
  EFC39219.1 181 NLGVYYFEMGEIMKTT-HHEYASELFKKAVD 210
                 3445666666666444.67777777777765 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.11
      TPR_12  27 ekaleiarrllGpdhpltattlrnLgrlyr 56 
                 e+a+e + ++l  ++ + a +  nLg +yr
  EFC39219.1 236 EEAMEWYLKAL--NN-GIAKAAVNLGVVYR 262
                 56777775553..23.58888888888887 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.43
      TPR_12  42 pltattlrnLgrlyral 58 
                 ++ a +++ Lg +y ++
  EFC39219.1 356 LGSAKAMHHLGVMY-RT 371
                 56788888888888.44 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 1.2
      TPR_12  46 ttlrnLgrlyral 58 
                  +++ Lg +y ++
  EFC39219.1 360 KAMHHLGVMY-RT 371
                 5666666666.33 PP

  == domain 5  score: 5.7 bits;  conditional E-value: 0.0088
      TPR_12   3 atalnnlaavl.rrlgrydeAlellekal 30 
                 a+a+  +a+++ +   ++deA++++ k+ 
  EFC39219.1 395 ASAQLCVADCYeNDKDDMDEAFKWYLKSA 423
                 6788899****666888********9984 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 2.6
      TPR_12  21 eAlellekal 30 
                 +A++++e a 
  EFC39219.1 487 KAIQYYENAA 496
                 5666666654 PP

  == domain 7  score: 6.2 bits;  conditional E-value: 0.0062
      TPR_12  49 rnLgrlyralgryeeAlelleeala 73 
                 ++L++l+++l++ye Al + +ea++
  EFC39219.1 540 FALAELFYLLEDYENALLWINEAIE 564
                 6899999999999999999999975 PP

  == domain 8  score: 0.9 bits;  conditional E-value: 0.28
      TPR_12  60 ryeeAlelleea 71 
                 +y +A+el+e+a
  EFC39219.1 587 DYSKAIELFERA 598
                 677888888876 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0      0.13   2.7e+02      37      59 ..     305     328 ..     289     329 .. 0.81
   2 ?    3.6   1.1     0.038        77      22      70 ..     394     441 ..     376     445 .. 0.72
   3 ?    8.5   0.2    0.0011       2.3      27      57 ..     540     569 ..     515     578 .. 0.82
   4 ?   -1.6   0.1       1.6   3.2e+03       4      16 ..     587     599 ..     586     616 .. 0.61

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.13
                 T-HHHHHHHHHCT.SHHHC-HHHH CS
      ANAPC3  37 gqykrAyellrka.klnskslgcr 59 
                 ++ +rA++ll+ka  l +k+  cr
  EFC39219.1 305 EDINRAMKLLKKAgSLGDKDAFCR 328
                 5799*********88888888887 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.038
                 -HHHHHHHHHHHHHTT-.HHHHHHHHHCTSHHHC-HHHHHHHHHHHHHTT CS
      ANAPC3  22 spedayllAlclylngq.ykrAyellrkaklnskslgcrylfAqcllkLk 70 
                 ++++ +  A c+ ++++  ++A++++ k+ ln+ + ++  l+A +ll+ +
  EFC39219.1 394 HASAQLCVADCYENDKDdMDEAFKWYLKSALNGDTRAA--LYAGALLANG 441
                 4555556799**999999***********776666655..6666666655 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0011
                 HHHHHHHHHTT-HHHHHHHHHCTSHHHC-HH CS
      ANAPC3  27 yllAlclylngqykrAyellrkaklnskslg 57 
                 ++lA+ +yl+++y+ A+ ++++a +++ +l+
  EFC39219.1 540 FALAELFYLLEDYENALLWINEA-IEEGDLE 569
                 789*******************9.5555554 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 1.6
                 -HHHHHHHHHHHH CS
      ANAPC3   4 nyknAiflaerll 16 
                 +y +Ai l+er+ 
  EFC39219.1 587 DYSKAIELFERAS 599
                 4777777777776 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       8.5   1.7e+04      52      61 ..     237     246 ..     236     254 .. 0.72
   2 ?    6.4   0.0    0.0072        14      18      60 ..     381     422 ..     378     431 .. 0.86
   3 ?    1.0   0.0      0.35   7.1e+02      14      45 ..     486     512 ..     484     529 .. 0.84
   4 ?    8.0   0.4    0.0023       4.5      33      64 ..     535     566 ..     514     570 .. 0.79
   5 ?   -0.9   0.0       1.3   2.6e+03      12      23 ..     587     598 ..     586     614 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 8.5
      TPR_16  52 eAaalyraal 61 
                 eA ++y++al
  EFC39219.1 237 EAMEWYLKAL 246
                 7779999988 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0072
      TPR_16  18 aaleaalkrdpssPdaaeAllllgdaal.rqgrlaeAaalyraa 60 
                 + ++ +lk+++    +a A+l  +d++   + +++eA  +y++ 
  EFC39219.1 381 KSFRYYLKSAK--LGHASAQLCVADCYEnDKDDMDEAFKWYLKS 422
                 78999*****7..55*************7778999999999875 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.35
      TPR_16  14 ddAaaaleaalkrdpssPdaaeAllllgdaal 45 
                 ++A+ ++e a  +d       +A+l lg+++ 
  EFC39219.1 486 PKAIQYYENAASMD-----STRAMLSLGVLLS 512
                 68999999999999.....9999999999886 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0023
      TPR_16  33 aaeAllllgdaalrqgrlaeAaalyraalraa 64 
                 +    ++l+++++ + +++ A+ ++++a++++
  EFC39219.1 535 DLYCKFALAELFYLLEDYENALLWINEAIEEG 566
                 566789**********************9765 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 1.3
      TPR_16  12 dyddAaaaleaa 23 
                 dy +A++++e+a
  EFC39219.1 587 DYSKAIELFERA 598
                 677778888776 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0      0.02        39       4      17 ..     179     192 ..     178     195 .. 0.88
   2 ?   -2.5   0.1       2.8   5.6e+03      18      28 ..     199     209 ..     198     211 .. 0.74
   3 ?    0.9   0.0      0.24   4.7e+02      18      28 ..     236     246 ..     236     247 .. 0.93
   4 ?   -1.2   0.0         1     2e+03       1      12 [.     251     262 ..     251     263 .. 0.82
   5 ?   -1.3   0.0       1.1   2.2e+03      15      27 ..     269     281 ..     267     281 .. 0.84
   6 ?    1.1   0.0       0.2   4.1e+02       2      12 ..     324     334 ..     324     339 .. 0.90
   7 ?   -0.2   0.6      0.52     1e+03      17      30 ..     343     356 ..     342     356 .. 0.84
   8 ?   -3.1   0.1       4.2   8.3e+03      15      26 ..     410     421 ..     408     422 .. 0.81
   9 ?    4.9   0.0     0.012        25      17      31 ..     485     499 ..     484     501 .. 0.82
  10 ?    7.7   1.6    0.0016       3.3       6      29 ..     541     564 ..     537     565 .. 0.92
  11 ?    4.2   0.1     0.021        41      16      27 ..     587     598 ..     587     598 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.02
                 HHHHHHHHHHTT-H CS
       TPR_1   4 lynlGnayfklgky 17 
                 l nlG+ yf++g+ 
  EFC39219.1 179 LSNLGVYYFEMGEI 192
                 78**********96 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2.8
                 HHHHHHHHHHH CS
       TPR_1  18 deAleyyekAL 28 
                 + A e ++kA+
  EFC39219.1 199 EYASELFKKAV 209
                 56888999997 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.24
                 HHHHHHHHHHH CS
       TPR_1  18 deAleyyekAL 28 
                 +eA e y kAL
  EFC39219.1 236 EEAMEWYLKAL 246
                 79********9 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 1
                 HHHHHHHHHHHH CS
       TPR_1   1 akalynlGnayf 12 
                 aka  nlG++y+
  EFC39219.1 251 AKAAVNLGVVYR 262
                 67778******7 PP

  == domain 5  score: -1.3 bits;  conditional E-value: 1.1
                 T-HHHHHHHHHHH CS
       TPR_1  15 gkydeAleyyekA 27 
                 ++  + +eyy+ A
  EFC39219.1 269 KDISKTIEYYSMA 281
                 788899****987 PP

  == domain 6  score: 1.1 bits;  conditional E-value: 0.2
                 HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayf 12 
                 +a+++lG +y+
  EFC39219.1 324 DAFCRLGEIYL 334
                 699*******7 PP

  == domain 7  score: -0.2 bits;  conditional E-value: 0.52
                 HHHHHHHHHHHHHH CS
       TPR_1  17 ydeAleyyekALel 30 
                  ++A  y++kA +l
  EFC39219.1 343 KEKAFYYFNKAAKL 356
                 58999******876 PP

  == domain 8  score: -3.1 bits;  conditional E-value: 4.2
                 T-HHHHHHHHHH CS
       TPR_1  15 gkydeAleyyek 26 
                  + deA + y k
  EFC39219.1 410 DDMDEAFKWYLK 421
                 5899**999977 PP

  == domain 9  score: 4.9 bits;  conditional E-value: 0.012
                 HHHHHHHHHHHHHHS CS
       TPR_1  17 ydeAleyyekALeln 31 
                   +A++yye A + +
  EFC39219.1 485 IPKAIQYYENAASMD 499
                 579*******98776 PP

  == domain 10  score: 7.7 bits;  conditional E-value: 0.0016
                 HHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyyekALe 29 
                  l+ +++ l++y+ Al   ++A+e
  EFC39219.1 541 ALAELFYLLEDYENALLWINEAIE 564
                 5899******************98 PP

  == domain 11  score: 4.2 bits;  conditional E-value: 0.021
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 +y +A+e +e+A
  EFC39219.1 587 DYSKAIELFERA 598
                 799999999998 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.42   8.3e+02       4      16 ..     179     191 ..     178     192 .. 0.89
   2 ?   -1.4   0.0       1.7   3.4e+03      16      29 ..     197     210 ..     193     212 .. 0.78
   3 ?    1.7   0.0      0.18   3.5e+02      18      28 ..     236     246 ..     236     248 .. 0.92
   4 ?   -2.9   0.0       5.3   1.1e+04       1      12 [.     251     262 ..     251     263 .. 0.82
   5 ?   -3.4   0.0       7.5   1.5e+04      16      27 ..     306     317 ..     305     320 .. 0.73
   6 ?   -2.5   0.0       3.8   7.7e+03       3      12 ..     325     334 ..     324     336 .. 0.83
   7 ?    2.5   0.1     0.098     2e+02      16      30 ..     342     356 ..     342     358 .. 0.91
   8 ?   -3.0   0.1       5.9   1.2e+04      16      30 ..     378     392 ..     375     392 .. 0.80
   9 ?    1.3   0.2      0.23   4.7e+02       4      27 ..     398     422 ..     395     424 .. 0.82
  10 ?    2.9   0.0     0.074   1.5e+02      18      31 ..     486     499 ..     484     502 .. 0.83
  11 ?    9.0   1.6   0.00084       1.7       5      29 ..     540     564 ..     537     566 .. 0.93
  12 ?    4.0   0.1     0.034        68      16      27 ..     587     598 ..     587     599 .. 0.94

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.42
       TPR_2   4 lynlGlayyklgd 16 
                 l nlG  y+++g+
  EFC39219.1 179 LSNLGVYYFEMGE 191
                 689*******997 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 1.7
       TPR_2  16 dyeeAleafekAle 29 
                 ++e A e+f+kA+ 
  EFC39219.1 197 HHEYASELFKKAVD 210
                 67789999***986 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.18
       TPR_2  18 eeAleafekAl 28 
                 eeA e++ kAl
  EFC39219.1 236 EEAMEWYLKAL 246
                 79********9 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 5.3
       TPR_2   1 aealynlGlayy 12 
                 a+a  nlG +y+
  EFC39219.1 251 AKAAVNLGVVYR 262
                 678889***997 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 7.5
       TPR_2  16 dyeeAleafekA 27 
                 d ++A ++++kA
  EFC39219.1 306 DINRAMKLLKKA 317
                 556788888887 PP

  == domain 6  score: -2.5 bits;  conditional E-value: 3.8
       TPR_2   3 alynlGlayy 12 
                 a ++lG++y+
  EFC39219.1 325 AFCRLGEIYL 334
                 7899****97 PP

  == domain 7  score: 2.5 bits;  conditional E-value: 0.098
       TPR_2  16 dyeeAleafekAlel 30 
                 + e+A  +f+kA +l
  EFC39219.1 342 NKEKAFYYFNKAAKL 356
                 679*********998 PP

  == domain 8  score: -3.0 bits;  conditional E-value: 5.9
       TPR_2  16 dyeeAleafekAlel 30 
                 d e+  +++ k+ +l
  EFC39219.1 378 DNEKSFRYYLKSAKL 392
                 668889999999876 PP

  == domain 9  score: 1.3 bits;  conditional E-value: 0.23
       TPR_2   4 lynlGlayyklgdy.eeAleafekA 27 
                   + +++y++ +d  +eA +++ k+
  EFC39219.1 398 QLCVADCYENDKDDmDEAFKWYLKS 422
                 566789999999999*******986 PP

  == domain 10  score: 2.9 bits;  conditional E-value: 0.074
       TPR_2  18 eeAleafekAleld 31 
                  +A++++e A + d
  EFC39219.1 486 PKAIQYYENAASMD 499
                 69********9887 PP

  == domain 11  score: 9.0 bits;  conditional E-value: 0.00084
       TPR_2   5 ynlGlayyklgdyeeAleafekAle 29 
                 ++l+++ y l dye Al + ++A+e
  EFC39219.1 540 FALAELFYLLEDYENALLWINEAIE 564
                 89*********************98 PP

  == domain 12  score: 4.0 bits;  conditional E-value: 0.034
       TPR_2  16 dyeeAleafekA 27 
                 dy +A+e+fe+A
  EFC39219.1 587 DYSKAIELFERA 598
                 79********99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (642 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       835  (0.0465726); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.74u 0.30s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 3663.99
//
Query:       EFC39220.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.6e-12   47.0  14.5     0.0081   17.0   0.2    6.1  7  WD40         WD domain, G-beta repeat
     0.0024   18.1   1.1        5.9    7.3   0.0    4.2  5  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
  ------ inclusion threshold ------
      0.014   15.9   5.4         22    5.7   0.1    5.1  5  PQQ_3        PQQ-like domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.51   3.1e+03       9      37 ..      16      35 ..       8      36 .. 0.65
   2 !   17.0   0.2   1.4e-06    0.0081       3      38 .]      52      94 ..      50      94 .. 0.78
   3 !   15.6   0.0   3.6e-06     0.022       8      38 .]     126     160 ..     119     160 .. 0.72
   4 ?   -0.2   0.1      0.37   2.2e+03      14      35 ..     190     214 ..     176     217 .. 0.59
   5 !    7.8   0.1    0.0011       6.4      10      35 ..     230     258 ..     221     261 .. 0.64
   6 ?   -2.8   0.0       2.5   1.5e+04      13      28 ..     279     294 ..     274     301 .. 0.70
   7 !   11.5   0.0   7.4e-05      0.44       9      38 .]     318     347 ..     309     347 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.51
                SSSS.EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  9 GHss.vtslafspdgawlasGsdDgtvriW 37
                +H   v+++         + G+ D  +r++
  EFC39220.1 16 TH-QvVNGV--------TV-GCQDSFIRMY 35
                56.325777........44.8889888876 PP

  == domain 2  score: 17.0 bits;  conditional E-value: 1.4e-06
                EEEEEESS.SSEEEEE.....EETTSSE.EEEEETTSEEEEEE CS
        WD40  3 clrtltGH.ssvtsla.....fspdgaw.lasGsdDgtvriWd 38
                + + l GH ++v++l+      s + +  ++sG++Dg vr++d
  EFC39220.1 52 PSGLLVGHlKPVSALDsvcfgSSENAKHrIVSGGWDGDVRVFD 94
                556688******9998888854444444889**********98 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 3.6e-06
                 ESSSS..EEEEE...EETTSSEEEEEETTSEEEEEE CS
        WD40   8 tGHss..vtsla...fspdgawlasGsdDgtvriWd 38 
                 +GH s  v +++      + a+l++G++D tvr+W+
  EFC39220.1 126 KGH-SmeVLAVShakLGAEEALLVTGGMDSTVRVWK 160
                 588.4465444433377777889************6 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.37
                 EEEE..EETTSSEEEEE..ETTSEEE CS
        WD40  14 tsla..fspdgawlasG..sdDgtvr 35 
                 +sl   +  +++ + s+  + Dg +r
  EFC39220.1 190 WSLTvdTGASNPVVYSSclH-DGMIR 214
                 55543344455557655244.99998 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.0011
                 S.SSEEEEE..EETTSSEEEEEETTSEEE CS
        WD40  10 H.ssvtsla..fspdgawlasGsdDgtvr 35 
                 H s+v++++    +++a l+s+s D++++
  EFC39220.1 230 HtSDVRHVKvtDLQSKATLISCSSDKSIK 258
                 766666665553355555667766****9 PP

  == domain 6  score: -2.8 bits;  conditional E-value: 2.5
                 EEEEEEETTSSEEEEE CS
        WD40  13 vtslafspdgawlasG 28 
                 v +++ ++++++l ++
  EFC39220.1 279 VMHFSLDDNNNMLYCA 294
                 6667778888888854 PP

  == domain 7  score: 11.5 bits;  conditional E-value: 7.4e-05
                 SS.SSEEEEEEETTSSEEEEE.ETTSEEEEEE CS
        WD40   9 GH.ssvtslafspdgawlasG.sdDgtvriWd 38 
                 +H +++t + +  ++ ++ +G + D+ vr+Wd
  EFC39220.1 318 AHrGGITKIVY--NKGLIYTGgGADKVVRVWD 347
                 78777888833..33336687468*******9 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.3   7.8e+03      54      69 ..      24      39 ..      21      42 .. 0.81
   2 ?    3.0   0.0     0.021   1.2e+02      51      80 ..      79     108 ..      73     167 .. 0.85
   3 ?   -1.0   0.0      0.37   2.2e+03      27      39 ..     156     167 ..     130     177 .. 0.59
   4 ?    2.8   0.0     0.024   1.5e+02      57      85 ..     208     235 ..     199     243 .. 0.83
   5 !    7.3   0.0   0.00099       5.9      14      88 ..     252     327 ..     243     331 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.3
  ANAPC4_WD40 54 avaysdgevrlldaes 69
                  v+++d+ +r+++  s
   EFC39220.1 24 TVGCQDSFIRMYHHFS 39
                 699******9998755 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.021
  ANAPC4_WD40  51 klLavaysdgevrlldaesgkvvhslsvks 80 
                  + ++ +  dg vr++da+s +++  l+ +s
   EFC39220.1  79 HRIVSGGWDGDVRVFDANSMECLVLLENTS 108
                  678888999999999999999987776555 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.37
  ANAPC4_WD40  27 qrvwtleedkeds 39 
                   rvw+  +++ed 
   EFC39220.1 156 VRVWKW-RTTEDA 167
                  244444.444444 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.024
  ANAPC4_WD40  57 ysdgevrlldaesgkvvhslsvksekavt 85 
                   +dg +r +d+ ++k+v +++ ++++ v 
   EFC39220.1 208 LHDGMIRGYDITTQKLVAKMKLHTSD-VR 235
                  689******************99885.44 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.00099
  ANAPC4_WD40  14 tedgellvfRlngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesg.kvvhslsvksekavtclg 88 
                  ++d+++ +  l g++v   +e+ + ++v +++   ++++L  a + g +r ld   g k v +++ ++   +t++ 
   EFC39220.1 252 SSDKSIKCVDLRGNKVSMRAENVSTNTVMHFSLDDNNNMLYCADNAGCIRSLDTRMGlKKVDEVKNAHRGGITKIV 327
                  6788999999*******999********************************998875556666555555566665 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.011        67      25      40 .]      82      97 ..      71      97 .. 0.87
   2 ?   -1.5   0.1      0.68     4e+03      23      34 ..     146     157 ..     134     163 .. 0.81
   3 ?    0.4   0.3      0.17     1e+03      18      40 .]     193     220 ..     158     220 .. 0.63
   4 ?    3.0   0.0     0.025   1.5e+02      21      39 ..     288     306 ..     273     306 .. 0.80
   5 ?    5.7   0.1    0.0037        22      15      38 ..     324     348 ..     316     349 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.011
       PQQ_3 25 yvgtgdGtlyAlDaet 40
                + g++dG ++ +Da++
  EFC39220.1 82 VSGGWDGDVRVFDANS 97
                55888********975 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.68
       PQQ_3  23 lvyvgtgdGtly 34 
                 l+++g++d t++
  EFC39220.1 146 LLVTGGMDSTVR 157
                 788999999886 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.17
       PQQ_3  18 avdgg....lvyvgtg.dGtlyAlDaet 40 
                 +vd g    +vy ++  dG ++ +D +t
  EFC39220.1 193 TVDTGasnpVVYSSCLhDGMIRGYDITT 220
                 4444422224555555777777777765 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.025
       PQQ_3  21 gglvyvgtgdGtlyAlDae 39 
                 ++ +y+++  G +++lD++
  EFC39220.1 288 NNMLYCADNAGCIRSLDTR 306
                 357**************75 PP

  == domain 5  score: 5.7 bits;  conditional E-value: 0.0037
       PQQ_3  15 sspavdgglvyvgtg.dGtlyAlDa 38 
                 +  ++  gl+y+g+g d  ++  Da
  EFC39220.1 324 TKIVYNKGLIYTGGGaDKVVRVWDA 348
                 5678999********8888888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2310.50
//
Query:       EFC39221.1  [L=424]
Description: esterase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.8e-21   75.9   0.0    4.7e-21   75.6   0.0    1.2  1  Abhydrolase_3  alpha/beta hydrolase fold
      6e-10   38.5   0.0      1e-09   37.7   0.0    1.3  1  Say1_Mug180    Steryl acetyl hydrolase
      0.006   15.9   0.0     0.0098   15.2   0.0    1.3  1  Hydrolase_4    Serine aminopeptidase, S33
     0.0076   15.9   0.0      0.013   15.2   0.0    1.3  1  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.087   13.4   0.0       0.12   12.9   0.0    1.1  1  Abhydrolase_6  Alpha/beta hydrolase family


Domain annotation for each model (and alignments):
>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.6   0.0   1.3e-24   4.7e-21       1     141 [.     177     316 ..     177     394 .. 0.83

  Alignments for each domain:
  == domain 1  score: 75.6 bits;  conditional E-value: 1.3e-24
                    EEEE--STTTS--TTTTHHHHHHHHHHHTSEEEEEE---TTTS-TTHHHHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHHHHHHHHHHHHHTT CS
  Abhydrolase_3   1 lvyfHGGGfvlgsldthdalcrelakelgavvvsvdYrlAPehpfPaavedalaalrwlaeqawelgadpsrivlaGdSaGGnlaaavalrardeg 96 
                    l++fHGGG+++g+++t  +l +++++  g   + vdY l Peh +  a+eda++a++wl+++       +++++  G+SaGG+la+ ++ r+++e 
     EFC39221.1 177 LIHFHGGGYLMGEPSTCYTL-ENICSTNGFDLFGVDYSLYPEHTIEDAIEDAFKAFKWLVDE-----KGAKHVISIGESAGGHLATMLVDRIAQER 266
                    689*************9765.6799************************************9.....57899*****************8888876 PP

                    ---........EEEEEEESE-SSTSSTTSHHHHHCHHTTTSSSSCHHHHHHHH CS
  Abhydrolase_3  97 epk........vagqvliyPvtdlertesesikkaeeladgplltraaldlfw 141
                    + +        ++g++ ++P+ d+ + +s+ + +a+++ d  +l+++al++f 
     EFC39221.1 267 QQNglddkyncIVGVIGLSPWCDV-TMTSPGMCDAKHV-D-RALPNKALNQFK 316
                    555799****************99.8889999877554.3.355666666555 PP

>> Say1_Mug180  Steryl acetyl hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.7   0.0   2.9e-13     1e-09     125     336 ..     177     381 ..     162     408 .. 0.70

  Alignments for each domain:
  == domain 1  score: 37.7 bits;  conditional E-value: 2.9e-13
  Say1_Mug180 125 llylHGGgfalklipvtlvfLsnlrklfpdmailvsDYtvtaakdqskkYplqvleslavydylvkskgfknvvvlGdSaGGnlvLslllk....... 215
                  l+++HGGg+ ++  p t   L+n+  + +   +  +DY++    +++++    + ++ + +++lv  kg k+v+ +G+SaGG l   l+ +       
   EFC39221.1 177 LIHFHGGGYLMG-EPSTCYTLENICST-NGFDLFGVDYSLYP--EHTIEDA--IEDAFKAFKWLVDEKGAKHVISIGESAGGHLATMLVDRiaqerqq 268
                  89*******887.7999999**99865.45667889****99..6666655..559**************************9998888774333322 PP

  Say1_Mug180 216 ..lsklnkvvlPkkaiaiSPWlnltildekekeylkasdklD.vlclkglelfgklyvnn....repeeelktdefvnieknfdievWseilekckll 306
                    l   +k     ++i +SPW+++t+ +      + + +++D  l  k+l+ f+k  ++      e + +  + ++ + ++   i+  ++i++  + l
   EFC39221.1 269 ngLD--DKYNCIVGVIGLSPWCDVTMTSPG----MCDAKHVDrALPNKALNQFKKWGIPLgfnqLERG-KNLSPNYFSKDR---IDRMKDITN--RFL 354
                  2221..244555689**********55443....3334456635788889999888777542111222.222334444444...566666665..467 PP

  Say1_Mug180 307 ityGddEilkdqikllidkiselkeksyse 336
                    y  +E l  +i  +i+ +    ++++s 
   EFC39221.1 355 FSYSRNERLTLEIDKFISILN---KNNFSV 381
                  777777777777777776554...444554 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   2.7e-06    0.0098      54     139 ..     219     312 ..     214     357 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.7e-06
  Hydrolase_4  54 sfddyvdDlaafvekvkeehpelplfllGhSmGGliallyl....lrypd........kvaglilsaPalkikaklk.appllklllkllgkllpklq 138
                   ++d ++D+ ++++ +++e++ + ++ +G+S GG +a+ ++    +++++         + g+i  +P++++    + +  +     k + ++lp+  
   EFC39221.1 219 TIEDAIEDAFKAFKWLVDEKGAKHVISIGESAGGHLATMLVdriaQERQQnglddkynCIVGVIGLSPWCDVTMTSPgMCDA-----KHVDRALPNKA 311
                  57899**********************************9977653333367888775677999999999999665333333.....33333333333 PP

  Hydrolase_4 139 v 139
                  +
   EFC39221.1 312 L 312
                  3 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   3.6e-06     0.013      33      93 ..     203     261 ..     176     268 .. 0.81

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 3.6e-06
                    EEEEETTSTTSSSTTTGB.CHHSHHHHHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHH CS
  Abhydrolase_1  33 illDlrGvgySspapacinddygtasvaddldrildalgddkltlvGhSmGGmialayaae 93 
                     ++Dl Gv+yS  +  +i d   + +  + +++++d  g ++++ +G S GG +a+++  +
     EFC39221.1 203 NGFDLFGVDYSLYPEHTIED--AIEDAFKAFKWLVDEKGAKHVISIGESAGGHLATMLVDR 261
                    589********999998764..444466667799**********************99766 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   3.4e-05      0.12      42     134 ..     209     337 ..     177     364 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.4e-05
                    GCS--HHHCHHH.HHHHCCTT..........TTSEEEEEETCHHHHHHHHHHCC................EE.EEES-..............---- CS
  Abhydrolase_6  42 pppldledladl.aalldelaa........gggpvvlvGHSlGGalalaaapla..............lvvg.vlldp........pp....talp 101
                    + +++l + +++ +a+ d+++a        g++ v+ +G S GG+la+++++                 +vg + l+p        p+      ++
     EFC39221.1 209 GVDYSLYPEHTIeDAIEDAFKAfkwlvdekGAKHVISIGESAGGHLATMLVDRIaqerqqnglddkynCIVGvIGLSPwcdvtmtsPGmcdaKHVD 304
                    34455555555545555555556667766789999**************8888899999***9999997788555555544444322244443444 PP

                    TTTS----TTHHHHHHTT-CCCCHCCHS-HSCC CS
  Abhydrolase_6 102 agllaaalelllallallrllawlsreplprlf 134
                     +l++ al+++++++ +l + ++ +++ l++ +
     EFC39221.1 305 RALPNKALNQFKKWGIPLGFNQLERGKNLSPNY 337
                    444777777777777766665555444333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (424 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       760  (0.0423894); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2462.56
//
Query:       EFC39222.1  [L=216]
Description: hypothetical protein NAEGRDRAFT_81365 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (216 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       968  (0.0539907); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.37u 0.24s 00:00:00.61 Elapsed: 00:00:00.41
# Mc/sec: 1581.82
//
Query:       EFC39223.1  [L=337]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0037   17.4   1.5      0.013   15.7   0.4    2.0  2  SPRY      SPRY domain
     0.0074   16.2   0.1      0.014   15.3   0.1    1.5  1  F-box_4   F-box


Domain annotation for each model (and alignments):
>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0     0.089     8e+02      33      68 ..     115     150 ..      94     181 .. 0.69
   2 !   15.7   0.4   1.4e-06     0.013       1     110 [.     189     317 ..     189     324 .. 0.72

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.089
                 STSSTTEEEEETETTEEEEETESCEEEESSSSTTSE CS
        SPRY  33 egddrgswglcgdngtrtsaeqskaygkqparegdv 68 
                  +++ +++ +c +++  + ++  ++  + + re++v
  EFC39223.1 115 HCENAYFFLYCLFRAFSFDKSGFPKRIPLKSREDEV 150
                 288999999999888777555444444435555554 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 1.4e-06
                 EEEEEEEET..CCTSSEEEEEE...........EETTSSSSSTSSS......TSSTTEEEEETETTEEEEETESCEEEESSSSTTSEEEEEEETTTT.. CS
        SPRY   1 khyfevkiq..saeggsisvGl...........ateqtdlsdksge......gddrgswglcgdngtrtsaeqskaygkqparegdviGvalDleeg.. 78 
                 ++y+ ++++  ++e ++ ++ l             +++              +++++  g+c ++ +++s  + + + ++   egdviGv +  +e+  
  EFC39223.1 189 RYYWAIHLTnyHEEVSNAWITLvgvdgfenqprNQDSY-------SlhyylgCGKSRGRGYCVNTHSKHSDGTCAYTISNINSEGDVIGVEYFQQERti 280
                 68999999999777788877665558555554444555.......45555559***************99999999999999********988888833 PP

                 EEEEEETTEEEEEEEE.STTTS....SEEEEEEE.ST CS
        SPRY  79 elsFtkngknlgvaFr.nvrga....elfPvvslgng 110
                 +++F+ +  n+ v ++ +++++     + P+vs+ + 
  EFC39223.1 281 SMKFYSQFGNVIVSYEyDLKESedisDFRPAVSIVSR 317
                 4568888888877775323332456788888887655 PP

>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.1   1.6e-06     0.014       4      40 ..       5      42 ..       2      84 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1.6e-06
     F-box_4  4 sLssLPlevlqh.iaslLDsfsLsqLslvskllrevcs 40
                 L ++P ev++  ++++LD  +L++L +++k++r++  
  EFC39223.1  5 LLVEIPSEVFEFvVCKFLDTKTLFSLMKINKRMRDILL 42
                6889******962679*******************853 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (337 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       992  (0.0553294); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.47
# Mc/sec: 2161.01
//
Query:       EFC39224.1  [L=310]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.2e-07   29.9   7.0    2.3e-06   26.7   1.9    3.6  3  EF-hand_1  EF hand
      3e-07   30.2   2.6    7.5e-07   28.9   1.6    2.2  2  EF-hand_8  EF-hand domain pair
    1.3e-05   24.7   6.6      0.002   17.9   0.4    4.4  4  EF-hand_6  EF-hand domain
    4.4e-05   23.8   5.1    8.9e-05   22.9   1.3    2.9  2  EF-hand_7  EF-hand domain pair
     0.0019   17.6   2.6      0.002   17.5   0.5    2.1  2  EF-hand_5  EF hand


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0       0.1   3.7e+02      16      27 ..     179     190 ..     178     192 .. 0.86
   2 ?    2.6   0.0     0.034   1.2e+02      12      28 ..     216     232 ..     215     233 .. 0.89
   3 !   26.7   1.9   6.5e-10   2.3e-06       1      27 [.     238     264 ..     238     266 .. 0.90

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.1
                 EEEHHHHHHHHH CS
   EF-hand_1  16 kIdfeEfkellk 27 
                 +I+++E+++l++
  EFC39224.1 179 FITIQELVSLIE 190
                 7*******9876 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.034
                 TSSSEEEHHHHHHHHHH CS
   EF-hand_1  12 DgdGkIdfeEfkellkk 28 
                 D++G I+ e +k+++++
  EFC39224.1 216 DRTGVISTEKLKDAVME 232
                 99**********99875 PP

  == domain 3  score: 26.7 bits;  conditional E-value: 6.5e-10
                 HHHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellk 27 
                 +++ i+re+D Dg+G+Idf+Ef  +++
  EFC39224.1 238 DIEAIIREVDEDGNGTIDFDEFYLMIN 264
                 5899******************98875 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.98   3.5e+03       9      28 ..     150     167 ..     150     171 .. 0.66
   2 !   28.9   1.6   2.1e-10   7.5e-07       2      49 ..     218     260 ..     217     265 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.98
   EF-hand_8   9 elrrilrilglkkglseeev 28 
                 +lr+ l+ l ++  ++e+e+
  EFC39224.1 150 DLRKVLKELETP--FNEDEL 167
                 577755555555..999996 PP

  == domain 2  score: 28.9 bits;  conditional E-value: 2.1e-10
   EF-hand_8   2 kgkItreelrrilrilglkk.glseeevdilfrefDtdgdGkisfeEFc 49 
                 +g+I++e+l++++   +  + g++  ++++++re+D+dg+G+i+f+EF+
  EFC39224.1 218 TGVISTEKLKDAV---M--EfGFTV-DIEAIIREVDEDGNGTIDFDEFY 260
                 89*********77...3..223555.4*********************8 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.035   1.3e+02       2      27 ..     130     156 ..     129     160 .. 0.76
   2 ?   -0.2   0.0      0.35   1.2e+03      16      27 ..     179     190 ..     177     194 .. 0.86
   3 ?    3.2   0.0     0.029     1e+02      11      27 ..     215     231 ..     214     234 .. 0.85
   4 !   17.9   0.4   5.6e-07     0.002       4      29 ..     241     266 ..     238     272 .. 0.83

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.035
   EF-hand_6   2 lreaFklf.DkdgdGkidaeElrkalr 27 
                 + ++F  +  kd+  k+   +lrk+l+
  EFC39224.1 130 ILKVFANYaNKDDQTKLELWDLRKVLK 156
                 568999993344444***********9 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.35
   EF-hand_6  16 kidaeElrkalr 27 
                 +i+++El++++ 
  EFC39224.1 179 FITIQELVSLIE 190
                 8******99875 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.029
   EF-hand_6  11 kdgdGkidaeElrkalr 27 
                 +d++G i++e l++a  
  EFC39224.1 215 FDRTGVISTEKLKDAVM 231
                 699*********99875 PP

  == domain 4  score: 17.9 bits;  conditional E-value: 5.6e-07
   EF-hand_6   4 eaFklfDkdgdGkidaeElrkalrka 29 
                 ++ ++ D dg+G+id++E+  +++++
  EFC39224.1 241 AIIREVDEDGNGTIDFDEFYLMINMK 266
                 556788**************999964 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.1      0.29     1e+03      11      44 ..     138     165 ..     118     172 .. 0.60
   2 !   22.9   1.3   2.5e-08   8.9e-05      18      67 ..     179     260 ..     175     264 .. 0.69

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.29
   EF-hand_7  11 lDtdgdgyldkeellrllrkifqgagegsklsde 44 
                   +d+  +l+  +l+++l+      + + ++ ++
  EFC39224.1 138 ANKDDQTKLELWDLRKVLK------ELETPFNED 165
                 4455666666666666666......555555554 PP

  == domain 2  score: 22.9 bits;  conditional E-value: 2.5e-08
   EF-hand_7  18 yldkeellrllrkifqga........................gegsklsdee.............lellfkefDtdkdGvisfdEFl 67 
                 +++ +el +l+++ + +                               s e+             +e++++e+D d++G+i+fdEF+
  EFC39224.1 179 FITIQELVSLIENQKKQDrpvhdnetlsafvamggnfdrtgvI-----STEKlkdavmefgftvdIEAIIREVDEDGNGTIDFDEFY 260
                 7888888888876444448888888888888777777444431.....33223333444555555*********************8 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1      0.56     2e+03      15      23 ..     179     187 ..     179     189 .. 0.80
   2 !   17.5   0.5   5.7e-07     0.002       2      24 ..     240     262 ..     239     263 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.56
                 CE-HHHHHH CS
   EF-hand_5  15 kIskeELkt 23 
                 +I+++EL  
  EFC39224.1 179 FITIQELVS 187
                 69****965 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 5.7e-07
                 HHHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5   2 kdtFqaiDlNgDGkIskeELktl 24 
                 ++  +++D +g G+I+++E++ +
  EFC39224.1 240 EAIIREVDEDGNGTIDFDEFYLM 262
                 667899**************965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       907  (0.0505884); expected 358.6 (0.02)
Passed bias filter:                      462  (0.0257683); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1768.96
//
Query:       EFC39225.1  [L=416]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-53  180.9   0.1    6.1e-53  180.1   0.1    1.3  1  PP2C      Protein phosphatase 2C
    0.00085   19.0   0.0     0.0019   17.9   0.0    1.5  1  PP2C_2    Protein phosphatase 2C


Domain annotation for each model (and alignments):
>> PP2C  Protein phosphatase 2C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  180.1   0.1   6.8e-57   6.1e-53       7     248 ..      26     292 ..      21     295 .. 0.87

  Alignments for each domain:
  == domain 1  score: 180.1 bits;  conditional E-value: 6.8e-57
                 EECCCCSSHHEEEECCCCTCTT........CCCCCCEEEEEEEEESSSHHHHHHHHHHHHHHHHHHHCHTTH.HHHHHHHHHHHHHHHHHHHH..HHHH CS
        PP2C   7 elqgarksmedahislanless........sgkssvsffavfdghggseaakyarehleeilksqksfeele.kleqalrksfladtdeelks..skan 94 
                  +qg r +medah+++ + ++          +++s +ff+vfdgh+g ea+k+++ ++  ++++  ++++   + ++ +  ++la +de+lk+  +  +
  EFC39225.1  26 GMQGSRPEMEDAHCLRLDIQNDlktlkqkpHQYKSLNFFGVFDGHAGAEASKFCADNILSVVDEHLEKSSNLeLSDELITAAYLA-LDEKLKTymE--K 121
                 69*************999998899999999999**************************77777766666553567788888888.9999999642..2 PP

                 ....CHCCT-EEEEEEEEEETTE....EEEEEESS-EEEEEETTEEEEECS---STTSHHHHHHHHHTT--EEECCEEETTTBSBSB-EE-GGGTCCCC CS
        PP2C  95 ....tepsksGstavvalirgtk....lyvAnvGDSravLcrkgnakkeltedHkpsdedEreRIeeaggsvsngegrvngsLavsRalGDlelkpket 185
                     +    sGst +++++   +     ++AnvGDSr+++  +g+++ e+++d+kp +e E++RIe+a+ +v   ++rvng+Lav+Ra+GD+++k +e+
  EFC39225.1 122 vqgiSPFNGSGSTGITCFVKVADcdveAICANVGDSRCIMYHNGKTI-EMSFDQKPMNEIEKKRIEAADCTVT--MNRVNGNLAVARAFGDFRYKGNEK 217
                 345434578***********99999**********************.*************************..********************9999 PP

                 ...CCSTSB---EEE......EEEE-TT.EEEEEEE-HHHHTTSHHHHHHHHHHHHHHHHT..HHHHHHHHHHHH CS
        PP2C 186 ...eeqlvsaePdvt......svkltee.defliLacdGlwdvlsdqeavdlvrdelekkk..speevaeelvde 248
                    e q+v + P++        +k ++   +fliLacdGlwd+++++ea+  v+++lek +  + +e++ +l++ 
  EFC39225.1 218 kkaEDQAVCCVPEIIrqkmdgFTKGNKTsPSFLILACDGLWDKFTNEEAALYVKQQLEKYDifNETEISSDLMQP 292
                 999999*********4444433333445578***************************98899999999998875 PP

>> PP2C_2  Protein phosphatase 2C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   2.1e-07    0.0019      26     185 ..      63     267 ..      53     291 .. 0.73

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 2.1e-07
      PP2C_2  26 llaVaDGaGSakrSerGariaveavvealaelleseeeeeeallraleaailadvlkeeaeaq.daelkdyatTllaavvt....pdeivalqiGDGai 119
                 ++ V DG+  a+ S++ a  +  +v e+l+++ + e    ++l++a+  a+++++    ++ q  ++++  ++T + ++v+    + e++++++GD+ +
  EFC39225.1  63 FFGVFDGHAGAEASKFCADNILSVVDEHLEKSSNLELS--DELITAAYLALDEKLKTYMEKVQgISPFNGSGSTGITCFVKvadcDVEAICANVGDSRC 159
                 45699*************************88843333..35555555555544422334445266889889998888855333467799********* PP

      PP2C_2 120 vvrdrdgevqllgepds.geyanq.....ttfltsedaeeel....................................rirrlkledgdalllmTDGla 176
                 ++++  +++   ++++  +e+  +       ++t++ + ++l                                     ++++++++++ l+l+ DGl 
  EFC39225.1 160 IMYHNGKTIEMSFDQKPmNEIEKKrieaaDCTVTMNRVNGNLavarafgdfrykgnekkkaedqavccvpeiirqkmdGFTKGNKTSPSFLILACDGLW 258
                 **9999998887774333333333323223445566666666889999999999999999999999999999999999999999999999999999999 PP

      PP2C_2 177 nslrdeerf 185
                 +++ +ee+ 
  EFC39225.1 259 DKFTNEEAA 267
                 999877753 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1066  (0.0594567); expected 358.6 (0.02)
Passed bias filter:                      616  (0.0343577); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.70u 0.35s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2275.74
//
Query:       EFC39226.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   13.1   3.2       0.23   12.3   2.6    1.8  1  Ntox50    Bacterial toxin 50


Domain annotation for each model (and alignments):
>> Ntox50  Bacterial toxin 50
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   2.6   1.3e-05      0.23      43      78 ..      72     108 ..      42     117 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.3e-05
      Ntox50  43 vvkdrkgkwrnkevvdfgevigvvvdketgeet.eTk 78 
                 + k+++++ +n  vvdf++vi +v ++++ ++t +T+
  EFC39226.1  72 ITKKKRKNSKNSVVVDFPSVITTVSNNNNSTNTtPTQ 108
                 4455689999************999866555431443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2129  (0.118746); expected 358.6 (0.02)
Passed bias filter:                      436  (0.0243181); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 933.36
//
Query:       EFC39227.1  [L=392]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.049   14.6   0.4       0.27   12.2   0.2    2.4  2  DUF1292   Protein of unknown function (DUF1292)


Domain annotation for each model (and alignments):
>> DUF1292  Protein of unknown function (DUF1292)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0      0.88   1.6e+04      56      68 ..     256     267 ..     252     271 .. 0.60
   2 ?   12.2   0.2   1.5e-05      0.27      12      55 ..     296     347 ..     292     349 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 0.88
     DUF1292  56 piedDeEleaVse 68 
                 pied  E +++++
  EFC39227.1 256 PIEDP-EVQQIFK 267
                 67644.5555555 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 1.5e-05
     DUF1292  12 etfeveg.keYill.de.aeee...eeeede.....evyilriveededgeeele 55 
                  tfe+++ +eY+l+ d+ +       +++ e     ev++l++ve+ ++ge++++
  EFC39227.1 296 CTFENDNlREYVLFrDDgE--PlklTSNN-EgiminEVFLLKVVEDRKEGEDMFY 347
                 589977689*****64422..13442222.2467878*****8877788998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (392 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1173  (0.0654247); expected 358.6 (0.02)
Passed bias filter:                      572  (0.0319036); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2317.41
//
Query:       EFC39228.1  [L=1136]
Description: SPRY domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-09   37.8   0.0    2.4e-09   37.0   0.0    1.3  1  Pkinase      Protein kinase domain
    8.2e-09   35.6   0.1      7e-08   32.6   0.0    2.6  2  SPRY         SPRY domain
     0.0014   18.0   0.0     0.0027   17.0   0.0    1.3  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   0.0     4e-13   2.4e-09     122     168 ..     731     777 ..     719     791 .. 0.90

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 4e-13
                 SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHH CS
     Pkinase 122 rDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEv 168
                  DlKpeNiL+ ++ + K++DFGl++  + + ++t ++g+  Y+AP +
  EFC39228.1 731 LDLKPENILLTRDMVAKVSDFGLSTISNPQRTMTCQIGSLFYMAPDL 777
                 6**********9999******************************87 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.35   2.1e+03      17      44 ..     417     446 ..     404     468 .. 0.70
   2 !   32.6   0.0   1.2e-11     7e-08       3     117 ..     949    1080 ..     947    1083 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.35
                 EEEEEETTSSSSSTSSSTSSTTE..EEEET CS
        SPRY  17 svGlateqtdlsdksgegddrgs..wglcg 44 
                 +vGlat q+ +  ++   ++r+s  + + g
  EFC39228.1 417 RVGLATVQYCKFVENKFESKRESqfFSYGG 446
                 799999999866555555555554366555 PP

  == domain 2  score: 32.6 bits;  conditional E-value: 1.2e-11
                  EEEEEET.......CCTSSEEEEEEEETTSSSSSTSSSTSSTTEEEEETETTEEE.....EETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTE CS
        SPRY    3 yfevkiq.......saeggsisvGlateqtdlsdksgegddrgswglcgdngtrt.....saeqskaygkqparegdviGvalDleegelsFtkngk 87  
                  yfevk+        +    ++ +G+a  +++     + g+ + s+g++ dng+++     ++   ++    +  +gdviG++l++++ge    kng+
  EFC39228.1  949 YFEVKLAdklfsnaQSSAPEVALGFAPFGYK----GMVGWMKNSIGFHVDNGRVYderdaTNGIADRVYLGSVSRGDVIGCLLNHKNGEFLVVKNGQ 1041
                  9999999999985555555566666666666....788******************999988888899999999**********************9 PP

                  EE.....EEEEESTTTS...SEEEEEEE..STCEEEEES CS
        SPRY   88 nl.....gvaFrnvrga...elfPvvslg.ngaslkinl 117 
                  +l     g+ F++  ++   ++ P++s++     +++nl
  EFC39228.1 1042 ELhnlshGTVFKHDHFKqshQFLPTISCSdIHLEMEVNL 1080
                  99888999999988877779******9975455555555 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.0   4.5e-07    0.0027     128     177 ..     732     778 ..     727     788 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 4.5e-07
                  T-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHH CS
  Pkinase_Tyr 128 dlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEsl 177
                  dl   N+Ll++++v+k+sDfGL+      + +++ + +  ++ +map   
   EFC39228.1 732 DLKPENILLTRDMVAKVSDFGLSTIS---NPQRTMTCQIGSLFYMAPDLN 778
                  89999******************977...444455556678888888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       543  (0.0302861); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.86u 0.34s 00:00:01.20 Elapsed: 00:00:00.54
# Mc/sec: 6329.16
//
Query:       EFC39229.1  [L=317]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    9.6e-17   61.5   0.0    2.6e-16   60.1   0.0    1.7  1  Peptidase_C26  Peptidase C26
    2.7e-09   37.1   0.0    4.5e-09   36.3   0.0    1.4  1  GATase         Glutamine amidotransferase class-I


Domain annotation for each model (and alignments):
>> Peptidase_C26  Peptidase C26
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.1   0.0   2.9e-20   2.6e-16       1     216 []      14     245 ..      14     245 .. 0.74

  Alignments for each domain:
  == domain 1  score: 60.1 bits;  conditional E-value: 2.9e-20
  Peptidase_C26   1 pvigitaneeslkkeavqdaeesylaasyveavekagglpvllpieedeedvkaildkldgllltGgq.dvePslygeepsekeeeadpeRdalel 95 
                    pvigi+a+   + + +++ +++ y+ a+yv++ve +g+++v l  + ++++++++ d+l+g+l++Gg  d+  ++   +      +++ +   ++ 
     EFC39229.1  14 PVIGILAQP--TLTGKISIYGKYYIDAAYVKFVESSGARVVPLRFDLPRDEMRSYFDQLNGILFAGGGvDLVEKNGDLT-----PYMKSQQMLVNW 102
                    9*****998..5699999*************************************************988544444444.....444444445555 PP

  Peptidase_C26  96 aL.iraalergvPilgiCrGlqllnvalGGt..lyqdiee...qsgltdhrehe.......qsaashavkvekgsllaellgseeievnslHhqai 178
                    a+  ++ +  ++P++g+C+G+q l++al  +  ++q+  +   +    d++++e       + ++ ++v+ ++ + +  llg++++  n  Hh +i
     EFC39229.1 103 AIeAYEKNGDYMPMWGTCLGFQGLAIALANDssVMQSGFDsenMAIPLDFTMPEskiiestRLFNPKEVDSVQMRDIVYLLGNKNVTFN-AHHDGI 197
                    5524678899****************997541133332221112222334444466655444788899999999999999995555555.566665 PP

  Peptidase_C26 179 ke........laeelrveAvae..DgviEaieseeakafvlgvQwHPE 216
                              l++++r +++     g   a  +e++k++++g Q+HPE
     EFC39229.1 198 PIdrwisnsnLNKQVRLISTNLdrNGRKYASLLEHSKYPIYGSQFHPE 245
                    4444898999999999888765226788888889999**********9 PP

>> GATase  Glutamine amidotransferase class-I
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.3   0.0   5.1e-13   4.5e-09      64     181 ..     100     254 ..      36     262 .. 0.68

  Alignments for each domain:
  == domain 1  score: 36.3 bits;  conditional E-value: 5.1e-13
                 HHHHCT......STS-EEEETHHHHHHHHHTTTEEEEEECEEEEEEEEEEEETTT........................CGGTTTTSEEEEEEEEEEEE CS
      GATase  64 ikeare......nkiPiLGICLGmQllaiefgrkvvkekekehhggtmrlgddet........................allyglknevierhrHryev 132
                 +++a+e        +P+ G CLG+Q lai+++ +   ++  +    +m +  d t                        +++y l+n+  +   H + +
  EFC39229.1 100 VNWAIEayekngDYMPMWGTCLGFQGLAIALANDSSVMQ-SGFDSENMAIPLDFTmpeskiiestrlfnpkevdsvqmrDIVYLLGNKNVTFNAHHDGI 197
                 444444333334589******************655444.44444444444444444555555555555555777777777777777777777777777 PP

                 ESG.....CHHHTTEEEEEEEETTE..EEEEEEEETT.TEEEESSBTTSTTSTTHHH CS
      GATase 133 npk.....elepaglevtaksedde..elmeiiekkn.pfvgvQFHPEststpegpe 181
                   +     + ++++++ + ++ d +  +++ + e+++ p++g QFHPE+++ + +p+
  EFC39229.1 198 PIDrwisnSNLNKQVRLISTNLDRNgrKYASLLEHSKyPIYGSQFHPEKSMFEWNPN 254
                 666678887777776666665554444999999888889**********98777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (317 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       428  (0.0238719); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.54u 0.26s 00:00:00.80 Elapsed: 00:00:00.46
# Mc/sec: 2050.59
//
Query:       EFC39230.1  [L=695]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (695 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.23s 00:00:00.83 Elapsed: 00:00:00.43
# Mc/sec: 4835.65
//
Query:       EFC39231.1  [L=797]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.8e-33  113.9   0.0    1.1e-32  113.3   0.0    1.3  1  Synapsin_C  Synapsin, ATP binding domain
    4.1e-14   52.7   0.1    3.7e-13   49.6   0.0    2.3  2  Synapsin    Synapsin, N-terminal domain
  ------ inclusion threshold ------
       0.02   15.0   2.2      0.043   13.9   2.2    1.5  1  Eapp_C      E2F-associated phosphoprotein
      0.027   14.9   0.5       0.12   12.8   0.5    2.3  1  BILBO1_N    BILBO1 N-terminal domain


Domain annotation for each model (and alignments):
>> Synapsin_C  Synapsin, ATP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.3   0.0   2.4e-36   1.1e-32       1     202 [.     582     794 ..     582     795 .. 0.88

  Alignments for each domain:
  == domain 1  score: 113.3 bits;  conditional E-value: 2.4e-36
  Synapsin_C   1 nslesvynfcdkpwvfaqlvkiykslggekfplveqtyypnhkemltlptf..pvvvklghahagmgkvkvenqy.dyqdiasvvalaktyataeafid 96 
                 nsl+s+y   ++p++   l  i    g++kfpl++q y+ + + +l  p+    vv+k+g a ag+gkv ++n+    +d    ++  + + t+e+fi 
  EFC39231.1 582 NSLHSIYLNLQRPFIHGILSGIRDEKGADKFPLIDQYYHGEPNSILFTPSSsdKVVIKVGSAEAGFGKVLLDNNNgTLRDFGGCITRYNDFFTSEPFIA 680
                 8**************************************999999999975227****************998762689******************96 PP

  Synapsin_C  97 .skydirvqkigsnykaymrtsisgnwkantgsamleqvamseryklw...vdsc..semfggldicavkavhs..kdgk..dyiievmdssmpligeh 185
                   k dir+qkig+n + y r  +s nwk n g ++l++v + + yk w   vd +  s+m   ++i ++ a++     gk  +yi+e+ d++  l  + 
  EFC39231.1 681 nRKCDIRLQKIGKNIRVYER--VSSNWKGNVGNSILKEVEVKKHYKEWikwVDEAvkSKMGSPMEIFTLDAIQVepEPGKfvEYILEINDCASGLAPDN 777
                 2689**************99..579*********************76222565333778889*****999765115676669**************** PP

  Synapsin_C 186 vvedkqliaelvvskms 202
                  +ed + i +lv+sk+s
  EFC39231.1 778 LQEDIRNIRDLVISKIS 794
                 ***************97 PP

>> Synapsin  Synapsin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.25   1.1e+03      63      94 ..     347     381 ..     323     384 .. 0.70
   2 !   49.6   0.0   8.2e-17   3.7e-13       5     101 .]     470     580 ..     466     580 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.25
    Synapsin  63 kvvrsfkpdfvlvrqhvrd...aagedyrslllgl 94 
                   +r+ +pd  +++ ++ d   +a e+yr++l g+
  EFC39231.1 347 FNSRNVTPDNYMLFMQIMDmvsKAFEKYRAILYGM 381
                 55778888865555555443546779999999998 PP

  == domain 2  score: 49.6 bits;  conditional E-value: 8.2e-17
    Synapsin   5 tLLviddqktdwskyfrgkklsGeydirVEqaefseln.lvaysdkg.....lvvdlkvsr......ngtkvvrsfkpdfvlvrqhvrd..aagedyrs 89 
                  +Lvid+++++w  +f +++l  +y++++Eq+ ++++  +++++d++     + ++l++ +       + + +r f+ +fvlvr+ v++    +++y +
  EFC39231.1 470 AILVIDSEQNNWDLLFSENNLLTKYNLEIEQTTWENIAsVTSFNDGNnkkraCEISLRPWKttctfnDRRNRQRIFHANFVLVRKLVQGlkIDQHNYVN 568
                 68**********************************962677665432222278888877788888667788999**************8778999*** PP

    Synapsin  90 lllglkyggvPs 101
                  llg++++++Ps
  EFC39231.1 569 HLLGMMHCNLPS 580
                 ***********8 PP

>> Eapp_C  E2F-associated phosphoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   2.2   9.6e-06     0.043      74     137 ..     159     224 ..     149     231 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 9.6e-06
      Eapp_C  74 lkykeaesekkkkkkkkskkkeekeeeaeaeeaeeeeeeeeeeeesyhpvkCseCste..vavldk 137
                 ++ ++++  + ++  +ksk+++++e+e+ +++ +++++++++++++yhp+ C +C+ e   ++ld 
  EFC39231.1 159 MSIRKSKIISPNNDISKSKNQSTSEDEDYDDDGSDSAQKTKSDKKKYHPIACVQCRCEqrYGLLDL 224
                 45555555555555556666666666666666777777788889*********9875411566665 PP

>> BILBO1_N  BILBO1 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.5   2.7e-05      0.12       8      70 ..     433     493 ..     426     512 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.7e-05
    BILBO1_N   8 sfesrp.svselleavervFraeasalresassletFtiarvqiyddesqkWteLesetqLhey 70 
                 +++  p + s++ ++++++F + ++  + sass+++F+i    + d e+++W+ L se++L + 
  EFC39231.1 433 EHDLFPsTTSKIISTAHTTFTTSKKMSSSSASSESKFAI---LVIDSEQNNWDLLFSENNLLTK 493
                 5566787999******************9*********9...888************9998754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (797 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1084  (0.0604607); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.35s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 4582.52
//
Query:       EFC39232.1  [L=417]
Description: PQ-loop domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.5e-24   84.0  11.6    1.7e-14   53.3   2.9    3.3  4  PQ-loop          PQ loop repeat
     0.0016   17.9   3.2     0.0035   16.8   3.2    1.6  1  Nucleoside_tran  Nucleoside transporter
     0.0026   17.1   3.5     0.0026   17.1   3.5    1.7  2  7TM_GPCR_Srv     Serpentine type 7TM GPCR chemoreceptor Srv
     0.0054   16.9   5.3        6.5    6.9   0.1    3.9  4  DUF2615          Protein of unknown function (DUF2615)
  ------ inclusion threshold ------
      0.022   14.0   3.2      0.038   13.2   3.2    1.3  1  Peptidase_M56    BlaR1 peptidase M56
       0.11   12.7   0.1       0.35   11.0   0.1    1.8  1  Alveol-reg_P311  Neuronal protein 3.1 (p311)
        0.2   12.5  13.6        2.7    8.8   0.0    3.9  3  ER_lumen_recept  ER lumen protein retaining receptor


Domain annotation for each model (and alignments):
>> PQ-loop  PQ loop repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.7   1.5   6.7e-15   1.7e-11       2      59 ..      66     123 ..      65     125 .. 0.94
   2 ?   -2.2   0.4       1.4   3.7e+03      33      43 ..     128     138 ..     128     149 .. 0.76
   3 ?   -3.7   0.6       4.3   1.1e+04      35      41 ..     204     210 ..     197     221 .. 0.48
   4 !   53.3   2.9   6.6e-18   1.7e-14       2      58 ..     270     326 ..     269     329 .. 0.93

  Alignments for each domain:
  == domain 1  score: 43.7 bits;  conditional E-value: 6.7e-15
     PQ-loop   2 seilgyislvlwlvsyiPQiikNykrkSteGlSilflllwllGdilsllylilngfpp 59 
                 s+++g+is+ +w+++++PQ+i N+k++ ++ lS+ +l+  +lGd +s+   i++g+++
  EFC39232.1  66 SFAVGMISIGFWMCALLPQVIANFKNRDASSLSTGYLIQITLGDACSMTAGIMSGQLI 123
                 7899********************************************9999998876 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.4
     PQ-loop  33 lSilflllwll 43 
                 lS +f+l++++
  EFC39232.1 128 LSAYFVLMDVV 138
                 79999999987 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 4.3
     PQ-loop  35 ilflllw 41 
                 il +l  
  EFC39232.1 204 ILAILVL 210
                 3333332 PP

  == domain 4  score: 53.3 bits;  conditional E-value: 6.6e-18
     PQ-loop   2 seilgyislvlwlvsyiPQiikNykrkSteGlSilflllwllGdilsllylilngfp 58 
                 ++ lg ++++l++ s++PQi +N++rk ++GlS+ ++ + +lG++++++++ l +++
  EFC39232.1 270 GFSLGCFCAILYMGSRLPQIFLNFRRKTCDGLSPIYFGIGILGNVCYCVSIWLYSSD 326
                 6789**********************************************9988765 PP

>> Nucleoside_tran  Nucleoside transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   3.2   1.4e-06    0.0035      58     156 ..     124     222 ..      96     237 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.4e-06
  Nucleoside_tran  58 lkesallYFivsivvvivcvilllvlkklefykeykqlklegslletkeelrqekee..eseskvkltaekskeg....eenvfvllkvilaki 145
                      ++   + YF++  vv+i  + ++ v++k  +y++ k++k    + e+++e+ ++++e  ++ +kv++  e+sk++    + ++++++ +il  i
       EFC39232.1 124 TQILLSAYFVLMDVVMIAQYFCFVVIPK--IYRKVKSRK---IQPEKNQEIANSQSElvNK-EKVEVKCENSKQQetilKSSIWISILAILVLI 211
                      4444567****************99986..577777777...4457888888888887444.35777777765551111345666666666666 PP

  Nucleoside_tran 146 kvlalsvvlvf 156
                          +s++l  
       EFC39232.1 212 TFFTTSTMLSN 222
                      66666655544 PP

>> 7TM_GPCR_Srv  Serpentine type 7TM GPCR chemoreceptor Srv
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   3.5     1e-06    0.0026     161     255 ..     123     243 ..     110     249 .. 0.74
   2 ?   -2.8   0.1       1.3   3.2e+03     171     187 ..     345     361 ..     327     386 .. 0.50

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 1e-06
  7TM_GPCR_Srv 161 ierftkialiv.vvvtciiliiayvllfvvlrkkkk......................kksqtkskslkrevrLaiqvlilvlaeliilifvilsly 234
                   i+ + + a++v + v++i+  +++v++ ++ rk k+                      k + + ++s+++e+ L   + i++la l++++f++ s +
    EFC39232.1 123 ITQILLSAYFVlMDVVMIAQYFCFVVIPKIYRKVKSrkiqpeknqeiansqselvnkeKVEVKCENSKQQETILKSSIWISILAILVLITFFTTSTM 219
                   44444444444044666777788888888888766357999999999888888887766666699****************************9999 PP

  7TM_GPCR_Srv 235 fsqtlntda...ifylRalYpils 255
                    s ++++++   + ++R+l+ +++
    EFC39232.1 220 LSNNVENAQkmnQKTMRKLLHAIN 243
                   986555444222668888887776 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.3
  7TM_GPCR_Srv 171 vvvvtciiliiayvllf 187
                   ++ ++++   + y +l+
    EFC39232.1 345 FLDIFIMWQFVYYNYLY 361
                   22222222223333332 PP

>> DUF2615  Protein of unknown function (DUF2615)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.3   3.3e+03      55      85 ..      63      93 ..      58      99 .. 0.75
   2 !    6.9   0.1    0.0025       6.5      54      95 ..     129     171 ..     109     180 .. 0.72
   3 !    6.4   0.3    0.0038       9.7      27      89 ..     171     232 ..     169     234 .. 0.73
   4 !    5.8   0.0    0.0056        14      16      37 ..     233     254 ..     229     283 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.3
     DUF2615 55 slfliallwlvvaavlfllrPsslrnasakn 85
                ++  +a+ ++ + + + +l P+ ++n+++++
  EFC39232.1 63 EIASFAVGMISIGFWMCALLPQVIANFKNRD 93
                5667788888999999999999999985443 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0025
     DUF2615  54 sslfliallwlvvaavlfllrPsslrna.saknkpsrkdnndd 95 
                 s  f+++ ++++   + f++ P+  r+  s+k +p+++++  +
  EFC39232.1 129 SAYFVLMDVVMIAQYFCFVVIPKIYRKVkSRKIQPEKNQEIAN 171
                 4556677778888899**********98766666666665444 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0038
     DUF2615  27 qsQsyCtDneCldeselpgpeaskeggsslfliallwlvvaavlfllrPsslrna.saknkpsr 89 
                 +sQs+  ++e ++  +  ++++++e+  ++ +++ ++++++++ f++    l+n+ ++ +k ++
  EFC39232.1 171 NSQSELVNKEKVEV-KC-ENSKQQETILKSSIWISILAILVLITFFTTSTMLSNNvENAQKMNQ 232
                 78888888888886.44.4466777888888888888888888888888888877677776665 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.0056
     DUF2615  16 lamrrLlsllrqsQsyCtDneC 37 
                   mr+Ll+ +++ Q+y+t ++ 
  EFC39232.1 233 KTMRKLLHAINEGQEYSTTQQD 254
                 68***************97664 PP

>> Peptidase_M56  BlaR1 peptidase M56
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   3.2   1.5e-05     0.038      40     157 ..     133     249 ..     128     254 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.5e-05
  Peptidase_M56  40 vllallipfipesavslpvkfetskinsaaskaplasaaskvlddkasalatdvkkvewktilkil.lliWivgalilllyliaallvlkkrfvrk 134
                    vl+ +++ + ++  v++p  + ++k ++ +++ ++ +a+s++  + +++ + +vk  ++k++  il + iWi + +il+l + +    + ++ v +
     EFC39232.1 133 VLMDVVMIAQYFCFVVIPKIYRKVKSRKIQPEKNQEIANSQS--ELVNKEKVEVKCENSKQQETILkSSIWISILAILVLITFFTTSTMLSNNVEN 226
                    666666666676778888888888888888888888888885..7777888899999999999999999***998888776666555555555*** PP

  Peptidase_M56 135 lgklraeelkeaLkeakeemqlk 157
                    ++k++++   ++L++++e ++++
     EFC39232.1 227 AQKMNQKTMRKLLHAINEGQEYS 249
                    ******99999999999888765 PP

>> Alveol-reg_P311  Neuronal protein 3.1 (p311)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   0.00014      0.35      24      54 ..     360     390 ..     354     397 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00014
  Alveol-reg_P311  24 lpkgrLPvpkEVNrKKedeveaaslippgsd 54 
                      l kg+ P +kEV  KK +e ++ s + + sd
       EFC39232.1 360 LYKGKKPESKEVKNKKVEELKVVSAMSTVSD 390
                      789******************9998766554 PP

>> ER_lumen_recept  ER lumen protein retaining receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.0     0.001       2.7     101     141 ..      73     113 ..      10     119 .. 0.83
   2 ?    5.4   5.8     0.012        30      33     143 ..     129     319 ..     114     324 .. 0.55
   3 ?    1.3   0.4      0.22   5.6e+02      12      66 ..     315     373 ..     307     396 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.001
  ER_lumen_recept 101 siiLesvAilPQlillqktgevesltshyvfalglyRalyl 141
                      si    +A+lPQ+i   k+++++sl + y++ ++l  a+++
       EFC39232.1  73 SIGFWMCALLPQVIANFKNRDASSLSTGYLIQITLGDACSM 113
                      4555668************************9999888876 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.012
  ER_lumen_recept  33 slyntlmkialillsiyiiyl..ilvkfkety.ekekDtfkle....................................llivpslllallfhp 87 
                      s+y +lm++++i+  ++ +++  i++k+k+   + ek + +++                                    +l++++++++     
       EFC39232.1 129 SAYFVLMDVVMIAQYFCFVVIpkIYRKVKSRKiQPEK-NQEIAnsqselvnkekvevkcenskqqetilkssiwisilaILVLITFFTT----- 216
                      5666666666655444422222344443222202222.222225556666666666667777777766666665544442222222222..... PP

  ER_lumen_recept  88 g.............ssktllevl..................................wtfsiiLesvAilPQlillqktgevesltshyvfalg 134
                      +             ++kt+ ++l                                   +f+ iL   + lPQ++l  + + ++ l   y  +  
       EFC39232.1 217 StmlsnnvenaqkmNQKTMRKLLhainegqeysttqqdhnsftfppntpvsivgfslGCFCAILYMGSRLPQIFLNFRRKTCDGLSPIYFGIGI 310
                      112222345555555555555554444444444444444444444444444444445677799************************9999988 PP

  ER_lumen_recept 135 lyRalylln 143
                      l  ++y++ 
       EFC39232.1 311 LGNVCYCVS 319
                      888888874 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.22
  ER_lumen_recept  12 lyalvfltryldlflylre.....eislyntlmkialillsiyiiylilvkfketyekek 66 
                      +y+++ +   +d  +yl +     + s++n++++i+++   +y  yl + k  e+ e ++
       EFC39232.1 315 CYCVSIWLYSSDS-AYLMTripwlVESTVNIFLDIFIMWQFVYYNYLYKGKKPESKEVKN 373
                      5554444333444.1222222346666788888888877777777777777555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (417 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2004  (0.111774); expected 358.6 (0.02)
Passed bias filter:                      767  (0.0427799); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.52
# Mc/sec: 2399.38
//
Query:       EFC39233.1  [L=1842]
Description: Hypothetical protein NAEGRDRAFT_59334 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1842 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       731  (0.0407719); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.94u 0.33s 00:00:01.27 Elapsed: 00:00:00.48
# Mc/sec: 11429.97
//
Query:       EFC39234.1  [L=284]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-29   99.9  30.0    0.00019   21.2   0.1    9.0  9  LRR_6     Leucine Rich repeat
    7.9e-18   64.0  25.0    0.00027   20.6   0.5    5.6  6  LRR_8     Leucine rich repeat
    3.7e-13   49.4  29.7    9.4e-05   22.7   0.3    7.0  8  LRR_4     Leucine Rich repeats (2 copies)
    3.3e-05   23.8  16.5          9    7.3   0.6    7.9  6  LRR_1     Leucine Rich Repeat
      0.001   18.6  10.0       0.51    9.8   0.3    4.1  5  LRR_9     Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.2   9.9e-07    0.0035       4      23 ..      64      83 ..      61      84 .. 0.92
   2 !   10.1   0.4    0.0002      0.72       4      16 ..      88     100 ..      85     102 .. 0.91
   3 !   20.3   0.2     1e-07   0.00038       3      24 .]     109     130 ..     107     130 .. 0.92
   4 ?   -1.2   0.0      0.81   2.9e+03      14      24 .]     144     154 ..     143     154 .. 0.85
   5 !   21.2   0.1   5.3e-08   0.00019       3      23 ..     157     177 ..     155     178 .. 0.91
   6 !    7.2   0.1    0.0016       5.8       2      20 ..     180     198 ..     179     202 .. 0.89
   7 !   17.3   0.8   9.6e-07    0.0034       5      24 .]     207     226 ..     203     226 .. 0.89
   8 !   21.0   0.0   6.2e-08   0.00022       4      21 ..     230     247 ..     227     249 .. 0.89
   9 ?    1.1   0.1      0.15   5.2e+02       4      19 ..     254     269 ..     252     269 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 9.9e-07
       LRR_6  4 hLteLdLsgNdIgDeGaeaL 23
                +Lt+Ld+ +  Ig+eG+e++
  EFC39234.1 64 NLTTLDIGYSRIGNEGLESI 83
                8*****************98 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.0002
       LRR_6   4 hLteLdLsgNdIg 16 
                 +Lt L++++N+Ig
  EFC39234.1  88 NLTRLNIRSNNIG 100
                 8***********8 PP

  == domain 3  score: 20.3 bits;  conditional E-value: 1e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt+Ld+  N Ig+eG+++++
  EFC39234.1 109 KTLTALDIGENSIGNEGVKSIS 130
                 69*****************996 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 0.81
       LRR_6  14 dIgDeGaeaLa 24 
                 dI+ eGa+ L+
  EFC39234.1 144 DINEEGAKYLC 154
                 5888****998 PP

  == domain 5  score: 21.2 bits;  conditional E-value: 5.3e-08
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt LdL+g +IgDeGa+ +
  EFC39234.1 157 PNLTILDLTGSNIGDEGAKFI 177
                 79****************976 PP

  == domain 6  score: 7.2 bits;  conditional E-value: 0.0016
       LRR_6   2 nthLteLdLsgNdIgDeGa 20 
                 +t+L++L Ls  dI+++G+
  EFC39234.1 180 STKLKHLFLSLADISNVGV 198
                 79****************8 PP

  == domain 7  score: 17.3 bits;  conditional E-value: 9.6e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L  L Ls NdIgDeG++ L+
  EFC39234.1 207 LVDLILSLNDIGDEGLKHLS 226
                 67799************996 PP

  == domain 8  score: 21.0 bits;  conditional E-value: 6.2e-08
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                  L +L++sgN+I+DeG+ 
  EFC39234.1 230 MLNYLNVSGNQITDEGVV 247
                 699*************96 PP

  == domain 9  score: 1.1 bits;  conditional E-value: 0.15
       LRR_6   4 hLteLdLsgNdIgDeG 19 
                 +L+  +++ N ++ +G
  EFC39234.1 254 NLKRISITNNLLTAVG 269
                 7999*******99988 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.49   1.8e+03      16      35 ..      23      42 ..      20      46 .. 0.59
   2 !   19.9   0.9   1.3e-07   0.00046      19      61 .]      57      99 ..      55      99 .. 0.87
   3 !   13.9   0.0   9.3e-06     0.034      23      61 .]     107     145 ..     102     145 .. 0.94
   4 !   20.1   3.6   1.1e-07   0.00039       1      61 []     157     217 ..     157     217 .. 0.98
   5 !    8.0   0.6   0.00065       2.3      44      61 .]     224     241 ..     213     243 .. 0.52
   6 !   20.6   0.5   7.5e-08   0.00027       3      56 ..     231     284 .]     230     284 .] 0.95

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.49
                E-TTSSTT-TT--EEE--SS CS
       LRR_8 16 lddeaFkglsnLkvLdLsnN 35
                ++ ++ k ++ L++L + +N
  EFC39234.1 23 ISSDFLKEFKYLRELTIIRN 42
                45555556666666666655 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 1.3e-07
                TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8 19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                ++ ++l+nL++Ld+++ ++     +++ +L++L+ L++++N++
  EFC39234.1 57 KSISDLKNLTTLDIGYSRIGNEGLESIGQLENLTRLNIRSNNI 99
                5778999999999999999999999999999999999999987 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 9.3e-06
                 T-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  23 glsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +l+ L+ Ld+++N++     +++s L+ L+sL ++++++
  EFC39234.1 107 NLKTLTALDIGENSIGNEGVKSISKLTELTSLFIDYDDI 145
                 799*******************************99886 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 1.1e-07
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 pnLt+LdL+ +++ + + ++  + ++Lk+L Ls   ++ +  + +s+L+ L  L Ls N++
  EFC39234.1 157 PNLTILDLTGSNIGDEGAKFIGQSTKLKHLFLSLADISNVGVNYLSSLNELVDLILSLNDI 217
                 79*******************************************************9987 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.00065
                 GGTT--S-.EEE--SS-- CS
       LRR_8  44 afsgLpsLrsLdLsgNrL 61 
                  +s+L+ L +L++sgN++
  EFC39234.1 224 HLSSLKMLNYLNVSGNQI 241
                 344555555555555554 PP

  == domain 6  score: 20.6 bits;  conditional E-value: 7.5e-08
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 L++L++s N++t+ +  + + ++nLk ++++nNllt + ++ ++ ++  + LdL
  EFC39234.1 231 LNYLNVSGNQITDEGVVFIREMENLKRISITNNLLTAVGENLIQEMSITTDLDL 284
                 789****************************************99998888887 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.13   4.8e+02      10      33 ..      20      42 ..      11      46 .. 0.68
   2 !    7.6   0.1    0.0015       5.4      17      36 ..      60      75 ..      54      86 .. 0.72
   3 !   15.3   4.3   5.8e-06     0.021       1      39 [.      63     102 ..      63     124 .. 0.64
   4 !    8.7   0.1   0.00069       2.5       2      38 ..     110     144 ..     109     148 .. 0.78
   5 !    8.6   0.2   0.00072       2.6      21      36 ..     155     169 ..     143     173 .. 0.76
   6 !   10.3   4.7   0.00021      0.76       1      39 [.     157     204 ..     157     223 .. 0.77
   7 !    6.9   3.1    0.0024       8.6       6      38 ..     210     243 ..     200     243 .. 0.73
   8 !   22.7   0.3   2.6e-08   9.4e-05       2      39 ..     230     268 ..     229     274 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.13
                SS---E-S-HHH-TT--EEE-.-S CS
       LRR_4 10 nNqltdiplleklpnLkeLdLsgN 33
                +N +++ ++l+ ++ L+eL++ +N
  EFC39234.1 20 DNEISS-DFLKEFKYLRELTIIRN 42
                466773.35667999999998676 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0015
                S-HHH-TT--EEE-.-S--- CS
       LRR_4 17 plleklpnLkeLdLsgNnli 36
                +    l+nL++Ld+ g ++i
  EFC39234.1 60 SD---LKNLTTLDI-GYSRI 75
                33...9*******9.54355 PP

  == domain 3  score: 15.3 bits;  conditional E-value: 5.8e-06
                 SS--EEE--SS---E-S-HH...H-TT--EEE-..-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpnLkeLdL.sgNnlitdl 39 
                 +nL++Ld++  ++   +l e   +l nL+ L++ s+  +i+ +
  EFC39234.1  63 KNLTTLDIGYSRIGNEGL-EsigQLENLTRLNIrSN--NIGLV 102
                 588888888658885444.33436888888888333..34433 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.00069
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                  L+ Ld++ N +   +   ++kl+ L++L +       d
  EFC39234.1 110 TLTALDIGENSIGNEGVksISKLTELTSLFIDYD----D 144
                 6999****99*99766676668*******99544....4 PP

  == domain 5  score: 8.6 bits;  conditional E-value: 0.00072
                 H-TT--EEE-.-S--- CS
       LRR_4  21 klpnLkeLdLsgNnli 36 
                  lpnL+ LdL+g  +i
  EFC39234.1 155 ELPNLTILDLTGS-NI 169
                 49********775.24 PP

  == domain 6  score: 10.3 bits;  conditional E-value: 0.00021
                 SS--EEE--SS---E-S-..HHH-TT--EEE-......-S...-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdL.....sgN...nlitdl 39 
                 pnL++LdL + ++ d +   +++ ++Lk+L L     s N   n++++l
  EFC39234.1 157 PNLTILDLTGSNIGDEGAkfIGQSTKLKHLFLsladiS-NvgvNYLSSL 204
                 8********88****99995446*******98333321.2344566555 PP

  == domain 7  score: 6.9 bits;  conditional E-value: 0.0024
                 EE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   6 LdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 L Ls N + d +l  l++l+ L +L++sgN +itd
  EFC39234.1 210 LILSLNDIGDEGLkhLSSLKMLNYLNVSGN-QITD 243
                 667756799877765556666777889999.8876 PP

  == domain 8  score: 22.7 bits;  conditional E-value: 2.6e-08
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                  L +L+ s+Nq+td +   ++ + nLk +++  Nnl+t +
  EFC39234.1 230 MLNYLNVSGNQITDEGVvfIREMENLKRISI-TNNLLTAV 268
                 6999**********99997557*********.88899987 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0     0.021        76       1      20 [.      64      83 ..      64      86 .. 0.77
   2 !    7.3   0.6    0.0025         9       1      13 [.      88     101 ..      88     132 .. 0.68
   3 ?    4.4   0.0     0.022        78       1      16 [.     158     173 ..     158     179 .. 0.81
   4 ?   -1.3   2.4       1.7     6e+03       1      12 [.     182     193 ..     182     228 .. 0.59
   5 ?    3.2   0.0     0.054   1.9e+02       2      14 ..     231     243 ..     230     250 .. 0.83
   6 ?    4.0   0.1     0.031   1.1e+02       1      14 [.     254     267 ..     254     276 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.021
       LRR_1  1 nLrhLdLsnnpllglppnsf 20
                nL++Ld+++ ++++ + +s+
  EFC39234.1 64 NLTTLDIGYSRIGNEGLESI 83
                8*******999866665555 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0025
       LRR_1   1 nLrhLdLsnnpl.l 13 
                 nL++L++++n++ l
  EFC39234.1  88 NLTRLNIRSNNIgL 101
                 79999998888731 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.022
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 nL+ LdL++ ++++ +
  EFC39234.1 158 NLTILDLTGSNIGDEG 173
                 8******999986655 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 1.7
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+hL Ls   +
  EFC39234.1 182 KLKHLFLSLADI 193
                 678886543222 PP

  == domain 5  score: 3.2 bits;  conditional E-value: 0.054
       LRR_1   2 LrhLdLsnnpllg 14 
                 L +L++s+n++++
  EFC39234.1 231 LNYLNVSGNQITD 243
                 679******9976 PP

  == domain 6  score: 4.0 bits;  conditional E-value: 0.031
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL+++ ++nn l+ 
  EFC39234.1 254 NLKRISITNNLLTA 267
                 8*********9964 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       0.6   2.2e+03     107     123 ..      26      42 ..      11      48 .. 0.59
   2 !    9.5   0.2   0.00018      0.63      63     128 ..      62     124 ..      51     149 .. 0.71
   3 !    6.4   0.2    0.0016       5.8      27     100 ..      95     169 ..      92     175 .. 0.46
   4 !    9.8   0.3   0.00014      0.51      65     127 ..     182     243 ..     175     246 .. 0.91
   5 ?    1.3   0.1      0.06   2.2e+02      63      87 ..     252     276 ..     246     283 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.6
       LRR_9 107 dPlaslkklellsllkn 123
                 d l ++k l+ l++++n
  EFC39234.1  26 DFLKEFKYLRELTIIRN 42 
                 34555555555555555 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00018
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 lk l tl +   ri    ++  e++ +le+l   n + ++++ ++P+++lk l+ l + +n++ n+
  EFC39234.1  62 LKNLTTLDIGYSRIG---NEGLESIGQLENLTRLNIRSNNIGLVEPIINLKTLTALDIGENSIGNE 124
                 555666666666654...444455666666666666666677889*************99998775 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.0016
       LRR_9  27 rgykipvienlGatldqfdtidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnel 100
                 r++ i ++e +   l  + ++d+ +n i +  + ++  l  l +l+++ + i   + +    lPnl+ l lt++++
  EFC39234.1  95 RSNNIGLVEPI-INLKTLTALDIGENSIGNegVKSISKLTELTSLFIDYDDINEEGAKYLCELPNLTILDLTGSNI 169
                 44444444444.2344444455555555322244455555555555555555555555555555555555555544 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00014
       LRR_9  65 rlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 +lk l+l+   i +++ +   +l +l  l+l+ n + + + l+ l slk l++l +  n +t+
  EFC39234.1 182 KLKHLFLSLADISNVGVNYLSSLNELVDLILSLNDIGDEG-LKHLSSLKMLNYLNVSGNQITD 243
                 79**********************************9965.799**********999998875 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.06
       LRR_9  63 lkrlktlllnnnrivriaegleevl 87 
                 ++ lk +++ nn ++ ++e+l + +
  EFC39234.1 252 MENLKRISITNNLLTAVGENLIQEM 276
                 6778999999999999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (284 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       298  (0.0166211); expected 358.6 (0.02)
Passed bias filter:                      219  (0.0122148); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1754.09
//
Query:       EFC39235.1  [L=554]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   1.6e-101  340.7   0.2     2e-101  340.4   0.2    1.0  1  COesterase     Carboxylesterase family
    1.1e-08   35.2   0.2    9.5e-08   32.1   0.2    2.0  1  Abhydrolase_3  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.033   13.7   0.0      0.065   12.7   0.0    1.4  1  Peptidase_S9   Prolyl oligopeptidase family


Domain annotation for each model (and alignments):
>> COesterase  Carboxylesterase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  340.4   0.2  3.3e-105    2e-101      21     512 .]      43     541 ..      29     541 .. 0.87

  Alignments for each domain:
  == domain 1  score: 340.4 bits;  conditional E-value: 3.3e-105
                 TCSEEEEEEEEESSB---GGGTTS--BE.----SSEEECBS---BESEECSSSSSCGHHCHHHBES---EEEEEEESSSSSTTSSEEEEEEE--STTTS CS
  COesterase  21 sekevdaFlGiPYAepPvgelRFkkPep.aepwtgvrdAtkfspaCpqnaeksekeekeleawvsEDCLyLnvytPkekkeakkklPVlVwihGggfqt 118
                 ++ +v +F Gi+Y++   g+ RFk  +p   + + v++At+f+ +Cpq ++ +   +      +sEDCL Ln++tP      ++++ V+VwihGg+f++
  EFC39235.1  43 NG-NVSSFIGIRYGQETSGNNRFKITVPfLYDQSSVVNATSFGHVCPQPTTATTLLSA-----MSEDCLNLNIWTPM--L--NESVQVMVWIHGGSFTS 131
                 33.9************************9999999***************88777664.....9************5..2..34456************ PP

                 -BGCGS-THHHHHHH.....TSEEEEE----HHHHH-B-SSTTSBS-HHHHHHHHHHHHHHHHGGGGTEEEEEEEEEEETHHHHHHHHHHHS.GGGT.T CS
  COesterase 119 gsaseydgsaLaaeg.....nvivVtinYRlGvlGFlstgdeeapGNvGllDqvlALrWVkenIasFGGdpervtlfGesAGaasvslllls.plsr.g 210
                 gs+s ydgs+ +++       v++VtinYRlG lGFls +++ ++GN+Gl+Dq  A+rWVk nI +FGG+p+++t++GesAG++s++ ll +  +s+ +
  EFC39235.1 132 GSGSIYDGSYWCSKAaemgiPVVLVTINYRLGSLGFLSDKTSGVNGNFGLYDQLEAIRWVKVNIRNFGGNPDKITVAGESAGGMSIACLLSTsIFSSeN 230
                 *************99999999****************************************************************98666552444459 PP

                 SBSEEEEES--TTSTTTSBSHHHHHHHHHHHHTTS-CSSHHHHHHHHHCS-HHHHHHCCGGSSSSSSTTC-SSS-B--SSSSSS-HHHHHHCGC....C CS
  COesterase 211 lfkraIlqSGsalspwaiqkkarkrakklakkvgckassskelveclrsksaeelldaqekaleasssklvsfaPvvdgdflpekPeellkseg....k 305
                 lf++ I+qSG  + p ++ ++ ++ a+++ ++++   + s  ++ clr+ +  ++++aq++         ++f+Pvvdg++l+e+  + l + +    +
  EFC39235.1 231 LFQQSIIQSG--ILPSSVLQNTLDGAQAFTNILKS--RVSCFTLACLRQLPFADFITAQRN---------MTFVPVVDGQLLSETIYQNLDKVNnpisN 316
                 **********..55666666666666666666666..4444779***************99.........*************98887777766789** PP

                 SEEEEEEETTTTHHHHCCHSTTTSSSSHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHSTTTSSTCHHHHHHHHHHHHHHHHTHHHHHHHHHHHH.. CS
  COesterase 306 vplliGvnkdegllflaylldkeksvkkkeeklsesllkdelyleaekkeelseaikeeytdeadrddaeksrkallelltdvlfkapvlrtaklha.. 402
                 + +++G++++e++ f     ++        + ++ ++l ++l++++   +++ e + +  +    + +++++ + ++ ++td+lf +p++ + + ++  
  EFC39235.1 317 ISMMVGTTRNETTAFTCDRGSN-------LNIYQLYVLFRTLFNMEP-LSSIFELLAQVSILYGGQGTYSSILQFFNVFMTDALFYCPARYYSSVVSem 407
                 ***************9955544.......555566666666666654.77777777777778899************************9999999888 PP

                 ........HTT-SEEEEEEE--STTSSST...TTGSSBTTTTHHHHTTGGGTSGCS...............S-HHHHHHHHHHHHHHHHHHHHSSTTS. CS
  COesterase 403 ........srgspvYlYsfdyrnssskkp...kwmgvvhgdeleyvfglpllekee...............ftkedeklsrkmmtywtnFaktgnPnk. 474
                         + + +vY+Y+f+y +     p   +  g+ h++el+y+f   l e ++               f+++d+k+s+ m+ ywtnF+k+g+P + 
  EFC39235.1 408 qknvssksRVERNVYQYVFSYVQ-----PklgPCYGAPHASELPYLFPSILDEIKNnpdlsgmfsdsqnleFSDKDRKISDSMIYYWTNFIKYGKPDGe 501
                 8999777556666********99.....334479****************999888899***********77777*********************999 PP

                 ...TTSS----B.TTTBEEEEESSSSSEEEESTTHHHHHHH CS
  COesterase 475 ...eeeekWpkytkeeekylkinlkpkrvkkklkeeevafw 512
                    ee ++W +++  eek+l i+ + k +++ +ke+ ++fw
  EFC39235.1 502 npkEEFPNWISFNRCEEKLLYIDIPLK-MEQAMKETICNFW 541
                 9988899******************95.************9 PP

>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.2   1.6e-11   9.5e-08       1      86 [.     121     218 ..     121     250 .. 0.79

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 1.6e-11
                    EEEE--STTTS--TTTT..HHHHHHHHHH.HTSEEEEEE---TT.........TS-TTHHHHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHHH CS
  Abhydrolase_3   1 lvyfHGGGfvlgsldth..dalcrelake.lgavvvsvdYrlAP.........ehpfPaavedalaalrwlaeqawelgadpsrivlaGdSaGGnl 84 
                    +v++HGG f++gs + +    +c++ a++ + +v v ++Yrl                  + d l+a+rw++ +  ++g +p++i++aG+SaGG  
     EFC39235.1 121 MVWIHGGSFTSGSGSIYdgSYWCSKAAEMgIPVVLVTINYRLGSlgflsdktsGVNGNFGLYDQLEAIRWVKVNIRNFGGNPDKITVAGESAGGMS 216
                    79********9999998768899999985367888899****97322221111233345789************99******************74 PP

                    HH CS
  Abhydrolase_3  85 aa 86 
                     a
     EFC39235.1 217 IA 218
                    44 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.1e-05     0.065      35      83 ..     171     222 ..     146     244 .. 0.72

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.1e-05
                   TTSGGGGHHHHHHHHHHHHHH...HHTTS--GGGEEEEEETHHHHHHHHHHH CS
  Peptidase_S9  35 agkrklgqnefdDfiaaaeal...akegyvdserlaitGgSyGGyltgaaln 83 
                   + ++ +g+  + D+++a++++   + ++  +++++ + G S+GG+ ++++l 
    EFC39235.1 171 KTSGVNGNFGLYDQLEAIRWVkvnIRNFGGNPDKITVAGESAGGMSIACLLS 222
                   445556666777777777777554778899***************9998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (554 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       464  (0.0258799); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 3608.68
//
Query:       EFC39236.1  [L=1917]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
   3.8e-262  871.4   8.0   3.8e-262  871.4   8.0    3.3  1  Myosin_head    Myosin head (motor domain)
    9.1e-14   50.3 287.1    6.9e-09   34.1  95.8    5.1  5  Myosin_tail_1  Myosin tail
    6.1e-06   24.7  26.8    6.1e-06   24.7  26.8    8.1  5  EzrA           Septation ring formation regulator, EzrA
    2.5e-05   24.0   0.4    2.5e-05   24.0   0.4    2.1  2  Myosin_N       Myosin N-terminal SH3-like domain
    9.6e-05   22.5  21.9    9.6e-05   22.5  21.9   14.7 14  ADIP           Afadin- and alpha -actinin-Binding
    0.00039   20.1  54.2    0.00039   20.1  54.2    9.9  7  Filament       Intermediate filament protein
    0.00072   19.8  24.5    0.00072   19.8  24.5   11.3  9  ATG16          Autophagy protein 16 (ATG16)
    0.00099   19.6  59.8     0.0027   18.2  22.7    8.9  8  Fez1           Fez1
     0.0015   18.3   5.1     0.0015   18.3   5.1   13.5  9  SKA2           Spindle and kinetochore-associated protein 2
     0.0042   17.1   9.5     0.0042   17.1   9.5   14.3 13  Laminin_II     Laminin Domain II
  ------ inclusion threshold ------
      0.025   13.5 267.7      0.037   12.9  32.3    9.4  9  Spc7           Spc7 kinetochore protein
        2.1    8.7   6.0        1.4    9.3   0.1    3.3  2  AAA_19         AAA domain
        3.8    7.0   9.1       0.47   10.0   0.1    3.7  3  BRI3BP         Negative regulator of p53/TP53


Domain annotation for each model (and alignments):
>> Myosin_head  Myosin head (motor domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  871.4   8.0  2.8e-265  3.8e-262       2     677 .]     113     773 ..     112     773 .. 0.97

  Alignments for each domain:
  == domain 1  score: 871.4 bits;  conditional E-value: 2.8e-265
                  SBGCGSSS-SHHHHHHHHHHHHHTT--EEEETTEEEEE--SS--STSSHHHHHHHTTS-GGGSSSSHHHHHHHHHHHHHHHTSEEEEEEESSTTSSHH CS
  Myosin_head   2 edlveLsllneasvlenlkkRykkdliYtysglvlvavnPykklkiysedvikaykgkkreelpPHifaiadeayrslledkenqsilisGEsGAGKt 99 
                  ed++ Ls+lne+svl nlkkRy++d+iYtysgl+lvavnPyk+l+iy++++ik+++gk+re+ +PH+f++ad ayr++l+++ nqs+l++GEsGAGKt
   EFC39236.1 113 EDMARLSHLNEPSVLFNLKKRYESDKIYTYSGLFLVAVNPYKNLPIYTDEIIKKHNGKRREDAEPHVFTVADVAYRQMLQNQLNQSMLVTGESGAGKT 210
                  9************************************************************************************************* PP

                  HHHHHHHHHHHHHSSSSSCTCTTHHHHHHHHHHHHHHHHHEEEESSETTEESSEEEEEEEEETTSSEEEEEEEEECE-GGGGT---TT--SBHHHHHH CS
  Myosin_head 100 eatKkvlqylasvaeskekveeeeleekilqsnPilEafGnAktvrndnssRFGKfieiefdakgkiagakietYLLEksRvvkqakeERnyHiFYql 197
                  e+tKk++qyl++ a+ ++    ++le+++lq+nP+lEafGnAkt+rn+nssRFGKfie++f+ +g iag+ki++YLLE  Rv  qa +ERn+H FYq+
   EFC39236.1 211 ENTKKIIQYLTATAGASH--GAGKLENQLLQTNPLLEAFGNAKTLRNNNSSRFGKFIEVDFNVSGYIAGCKIQHYLLETTRVTAQAGDERNFHFFYQI 306
                  ************999998..689*************************************************************************** PP

                  HHCSTHHHHHHTT--TCCGSTTTTTTSSSSBTTS-HHHHHHHHHHHHHHHT--HHHHHHHHHHHHHHHHHCTSSEEEECTTSSEEESSHHHHHHHHHH CS
  Myosin_head 198 lagaseeekkelkledvkdyaylsqsgeltvdgiddseefketkkaldilglseeeqkeifrivaailhlGniefkkeakdeqavledeeklekaael 295
                  l++a  + +++++l++v++yay+sqsg+++v+gi+d+ ef+et ka+ i+g+se+e+    riva+ilhlGn +f k+++d  ++l++++ l++a+el
   EFC39236.1 307 LSDA--QARNKYHLTNVNSYAYVSQSGCTSVPGINDAMEFQETLKAMRIIGISEDEIDATCRIVASILHLGNCKFVKDDED-LSMLPERSPLNTASEL 401
                  *986..67899******************************************************************9987.588888889******* PP

                  HTS-HHHHHHHHHSEEEEETTEEEEEE-BHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSS-S-SEEEEEEEEE-B---SSB-HHHHHHHHHHHH CS
  Myosin_head 296 lgvdaeelekalvkrriktgkevvskalnveqaevardalakaiyerlFdwlverinkslekkkeekksfiGvLDiaGFEifeknsFEqlcinyvnEk 393
                  l+vd e l+k ++k++i t ++++ ++ nv qa + r+al k +y+rlFdwlv+ in+sl++k+ + k+fiGvLDiaGFEife nsFEqlciny+nEk
   EFC39236.1 402 LCVDPEGLAKGFMKPNIITPTDIIETHVNVAQAGFNRSALVKSMYNRLFDWLVRSINQSLTSKE-KIKNFIGVLDIAGFEIFELNSFEQLCINYTNEK 498
                  **************************************************************99.9******************************** PP

                  HHHHHHHHHCHHHHHHHHHTTSSGCGS-GGGCCHHHHHHHHSSSTSHHHHHHHHHTSTTS-HHHHHHHHHHHHTTSTTEEETTSTTTTTEEEEEETTC CS
  Myosin_head 394 LqqlFnelvlklEqeeYvrEgiewkfidfgldnqaiidLiekkplGilslLdeecllpkatdetfleklvkafskhakfeksrlkkgeakFiikHyAg 491
                  Lqq+Fn++++k+EqeeY +E+iewkfidfgld+q++idLiek plGil++Ld+++ +++ ++e ++ +++k++ ++++f+ sr   +e++Fi++HyAg
   EFC39236.1 499 LQQFFNHHMFKKEQEEYLKEKIEWKFIDFGLDLQPTIDLIEK-PLGILAILDQQTFMAQQSEEGLVREINKNHGTKKQFKTSR--FNEKEFILSHYAG 593
                  *****************************************9.9***********************************9998..59*********** PP

                  EEEEE-TTHHHHHH----HHHHHHHHTSSSHHHHHHCCSHCHB--.........CSSSECCCCCSBHHHHHHHHHHHHHHHHCTSEEEEEEEE-SSSS CS
  Myosin_head 492 kveYevegfleKnkDtlnedlvellksskkkllaelfkeeekeakaeakksekkkkkkkkkkkfktvgskfkeslaeLmktlestnphfvRCikpnek 589
                  +v Y+v ++ +Kn D+lned  +++ +s + l+++lf+   +       ++++++k++  +++fktv++++k++l++Lm  lest+phf+RCikpn+ 
   EFC39236.1 594 DVPYNVVQWFTKNVDPLNEDCKSTMIASGNTLIKSLFDVPGE-------RTKANEKRSVGSARFKTVATNYKNQLKDLMGLLESTEPHFIRCIKPNNL 684
                  *************************************99554.......34445556667779*********************************** PP

                  --TT---HHHHHHHHHHTTHHHHHHHHHHSSSEEEEHHHHHHHHGGGSTTSS-SS.SSSHHHHHHHHHHHTTS-.GCGEEECSSEEEET CS
  Myosin_head 590 kkakkldeslvleqlrclGvlegirirraGfpnRitfeefvqrYkllakkelkkllkedakkaveailkeleld.keeykiGktKiFfr 677
                  +k++ +d++lvl+ql+c+Gvlegiri+r+G+p Ri ++efv+rY ll++++   +++ + +  ++ il++++ + + +yk+G tK+F++
   EFC39236.1 685 QKPAIIDDRLVLHQLKCNGVLEGIRIARKGYPGRIPYAEFVKRYDLLVEDKRSLEQQPNLRGKAQVILDSIKFEeTTQYKLGATKVFLK 773
                  *************************************************99877788899999********9873689*********97 PP

>> Myosin_tail_1  Myosin tail
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5  32.1      0.15     2e+02     544     669 ..     853     982 ..     847     989 .. 0.75
   2 !   34.1  95.8     5e-12   6.9e-09     220     600 ..     950    1322 ..     945    1327 .. 0.91
   3 !   22.7  51.9   1.4e-08     2e-05     360     600 ..    1320    1553 ..    1314    1560 .. 0.85
   4 ?    2.3  22.6     0.021        29     500     612 ..    1502    1612 ..    1495    1621 .. 0.72
   5 !    4.8  96.8    0.0035       4.8     651     964 ..    1566    1885 ..    1563    1915 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.15
  Myosin_tail_1 544 eeakkrlqrelealtqrleekaaaydklektkkRlqqeldDllvdldkqrqlvsnlekkqkkfDqlLaeekaisaklaeeRdraeaeaReketkal 639
                    e+  k+l+ ++e+l+++le  + ++ kle  k+ l+q    l+ dl++qr+ + +++ +  + ++ L + k    + + + d  ++e   ++t+a+
     EFC39236.1 853 EQVTKKLKEDFEQLKKDLEGEKDSKKKLETEKNALEQSRKKLIDDLEEQRNRLDTMNNHMNQLEKELNDRKRELERSQKDNDDKDSEIT-RNTQAI 947
                    77788999999999999999899999999999999999999999999999999999999999999999998888888888887777753.444444 PP

  Myosin_tail_1 640 s.l...araleea.kdakeelerankalraeledL 669
                    + l   +++leea +d+k+e+e+ +k +++   dL
     EFC39236.1 948 AaLnqaQKKLEEAiRDMKNEIEQREKIIKSKGGDL 982
                    31211135676642688888888888888766555 PP

  == domain 2  score: 34.1 bits;  conditional E-value: 5e-12
  Myosin_tail_1  220 lqeqiadlqaqieelraqlakkeeelqaalarleeeaaqknaalkklreleaqlaelqedlesekaaRakaekqrrdLgeeLealkteLedtLD 313 
                     l++ +  l+  i ++++++ ++e+ +++    l+++  + +++ kk ++l+ ++a+l+++l   ++  +   ++   L+ eL     +Le+  +
     EFC39236.1  950 LNQAQKKLEEAIRDMKNEIEQREKIIKSKGGDLQNKDLEIETLNKKAKDLDKRIADLENNLADSRNEINNKSNEISRLQMELSDQGIQLENESN 1043
                     56667789999***************************************************999999888888899***************** PP

  Myosin_tail_1  314 staaqqeLrskReqevaeLkkaleeearsheaqlqelrqkhtqaleelseqleqakrskaslekakqaLesenkelqaelkslqqakqdseqkr 407 
                        a++e  +kR++++++Lkk l + + + ++  +el+ k ++  + l+e+l+++k+s  +l++   a e+ +++l+ +l   + ++q +e+k 
     EFC39236.1 1044 NRKAREEDLKKRDKDIKDLKKELTDSQLAGDQLDSELK-KTKKEKQGLEEDLDKQKKSADNLQRKLTATEQSAQNLSNQLDEETRKRQGAENKN 1136
                     *******99**************998888777777776.55666799*********************************************** PP

  Myosin_tail_1  408 kkleaqlqelqvklseserqreelaekvsklqaelesvsslleeaegksiklskdvsslesqlqDtqellqeetrqkLalssrlrql.eeekna 500 
                     + l++ l++ ++k+++ e + +++ + +++lqae++++++ + + e+++ kl    + le +l Dt+  ++ee ++k +   rl++l e  k  
     EFC39236.1 1137 RSLQSDLDNANSKVNDLENAVHDRDDLIAQLQAEINKLKQRIADLESENQKLLERNKDLERELSDTKFRMDEELKNKNNEIDRLKKLsESSKDE 1230
                     **************************************************************************************9566799* PP

  Myosin_tail_1  501 lkeqleeeeeakknvekqlstlqaqlsdlkkkleeeasavealeeakkrlqrelealtqrleekaaaydklektkkRlqqeldDllvdldkqrq 594 
                     l+ ql+  ++ k+++  +l++++++l++lkk  ++ ++  + ++    r +++ ++++++le  +aa+d l++tk+R     d l  dld+q++
     EFC39236.1 1231 LTLQLNRTNDEKNDLLNKLKKADKDLKNLKKNKDDLQQEKDDAD---NRRNKDAQKKQTDLEL-QAAKDELNRTKQRA----DQLQTDLDNQKE 1316
                     *******************************9999887665555...5556788888888765.6789******9996....567788888888 PP

  Myosin_tail_1  595 lvsnle 600 
                       ++le
     EFC39236.1 1317 RANELE 1322
                     888887 PP

  == domain 3  score: 22.7 bits;  conditional E-value: 1.4e-08
  Myosin_tail_1  360 elseqleqakrskaslekakqaLesenkelqaelkslqqakqdseqkrkkleaqlqelqvklseser...qreelaekvsklqaelesvsslle 450 
                     el+  l ++   k +l+ + + L    ++l+ e +++++ k+++e+ +++l++  + l+ k+ses     + + l+ek++ l+a les  s+ +
     EFC39236.1 1320 ELESALSDTEGGKNQLDNQFKQLQ---TDLNNERNNVNKLKTEAEKLQRQLDEATRALSDKSSESSNldaKVRALEEKIRELTALLESERSSKS 1410
                     555555555555555555544443...3455555679999**************999*999999976221445789****************** PP

  Myosin_tail_1  451 eaegksiklskdvsslesqlqDtqellqeetrqkLalssrlrqleeeknalkeqleeeeeakknvekqlstlqaqlsdlkkkleeeasaveale 544 
                     e+++k++k+ k+++ l  qlq ++++l+ et++k +  +r++qle+e n++k+        + +++k+l++ + ++s  k++lee ++ +  l 
     EFC39236.1 1411 ESDKKKSKSDKEIKRLAEQLQGVESQLKSETQKKNDADNRVKQLENELNTVKN-------ERDRLNKDLTNQSGDVSGAKRQLEEANTQIARLK 1497
                     ***********************************************999875.......47789***************************** PP

  Myosin_tail_1  545 eakkrlqrelealtqrleekaaaydklektkkRlqqeldDllvdldkqrqlvsnle 600 
                      +  +l+++l++   + +e  ++ d l k+ + l   l D   +++++ +  +++e
     EFC39236.1 1498 ADILKLTKDLQERDGDKDEADEQLDGLRKQIQDLTSRLGDANNKQQQEASSRQSIE 1553
                     ****************************************9999888766666665 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.021
  Myosin_tail_1  500 alkeqleeeeeakknvekqlstlqaqlsdlkkkleeeasavealeeakkrlqrelealtqrleekaaaydklektkkRlqqeldDllvdldkqr 593 
                     +l+  l+e    k +++ ql  l++q++dl  +l + ++  ++   +++ ++ e + l++++   a   d lek +kRl+qe++ +l + d+++
     EFC39236.1 1502 KLTKDLQERDGDKDEADEQLDGLRKQIQDLTSRLGDANNKQQQEASSRQSIESENNRLKTDI---ARLRDDLEKENKRLKQEVERVLAESDNDK 1592
                     57777888888888888888888888888888888877766655555555555544444443...45678999999999999999999999876 PP

  Myosin_tail_1  594 .qlvsnlekkqkkfDqlLae 612 
                      +l+++l k q ++ +l  e
     EFC39236.1 1593 nDLLTQLKKIQEQYSELKDE 1612
                     25889999999998876555 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.0035
  Myosin_tail_1  651 akeelerankalraeledLvsskddvGknvheLerskraleqqveelktqleeLeDe........LqatedakLRLevnlq..alkaqfeRdlq 734 
                      +++le++nk l+ e+e +++  d+  kn  +L    + +++q +elk  +++L           ++ +e  kLR e ++q   lka+ e  + 
     EFC39236.1 1566 LRDDLEKENKRLKQEVERVLAESDN-DKN--DLLTQLKKIQEQYSELKDEFKDLQKQprggvaggVDSAEVEKLRREYEMQlaQLKARVEE-VT 1655
                     5899999999999999987764443.343..333333334444555555555554432222222278899999999988884346788875.44 PP

  Myosin_tail_1  735 ardeqgeekrrqlvkqvreleaeleeerkqraqavaakkkleldlkeleaqidaankgrdealkqlkklqaqlkdlqRel...eearasrdeil 825 
                     ++  + e+k+r++   + el + l+ e + r +a   kk  el+ +el++  ++++  rde  +     qa +++l  +l    + ras de+ 
     EFC39236.1 1656 NQRVEVENKKRSVEMDLTELKTRLQTEERLRKKAEQQKKSAELECDELRELAEESEDLRDELNRNKLEQQALIQQLRTDLlqeRNQRASADEVS 1749
                     5555568899999999999999999999999999999999999999999999999999999988877888877777777632235678888887 PP

  Myosin_tail_1  826 aqa.kesekklksleaellqlqedlaaaerakrqveqerDeladeiasgaskksalldekRrleariaqleeeleeeqsnvellndrlrkatlq 918 
                     +   +e+e   + le e  +l+e   aa r k+q e+e  +l++ +a+ +++++  + e+++ +  + +++  l+ee  ++  l+++l k++  
     EFC39236.1 1750 SRVrRENEELKQDLEQERSKLDE---AARRLKQQYENELLDLNNQVAQAKKERASASREQKKADRDLREFQRRLQEESRSKQDLEQKLTKTERE 1840
                     76525777777789999999988...78899999999999999999999999999999999999999999999999999999999999999999 PP

  Myosin_tail_1  919 veqltaeLsaeRsasqksesarqqlerqnkelkakLqelegavksk 964 
                     +  l+++ +++ s+ qkse+ +++le +n++ k kL el++ +  k
     EFC39236.1 1841 NKLLQSQSQSDASKLQKSEQDKSKLEAENRQQKDKLLELQDDLE-K 1885
                     99999999999999999999999999999999999999877653.4 PP

>> EzrA  Septation ring formation regulator, EzrA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1  25.1    0.0019       2.6     276     402 ..     852     975 ..     846     981 .. 0.90
   2 ?   -0.1  43.3      0.15     2e+02     196     417 ..     989    1207 ..     980    1223 .. 0.61
   3 ?   -3.0  24.9       1.1   1.5e+03      46     169 ..    1246    1370 ..    1234    1380 .. 0.51
   4 !   24.7  26.8   4.4e-09   6.1e-06     252     430 ..    1358    1535 ..    1355    1539 .. 0.92
   5 ?    2.6  10.5     0.022        31     274     383 ..    1550    1615 ..    1538    1621 .. 0.45

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0019
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTSSSSSHHHHT--HHHHTTGGG-TTTS-GGGSSTTTSTTHHHHHHHHHHHHHHHHHHHHHHS-SS--- CS
        EzrA 276 veeelktieeeidsLyddlekEveAkkeveknlkelkeklehlekqnkelkeeldrlkqsYeLseeeleklrelekelkelekdyeeleekleekkvaY 374
                 +e+  k+++e++++L +dle E+++kk+ e++ + l++  ++l + ++e ++ ld ++++ +   +  ++l++ ++el++ +kd ++ + +++ +++a 
  EFC39236.1 852 SEQVTKKLKEDFEQLKKDLEGEKDSKKKLETEKNALEQSRKKLIDDLEEQRNRLDTMNNHMN---QLEKELNDRKRELERSQKDNDDKDSEITRNTQAI 947
                 678899*************************************9999999999999988644...345566778899********************** PP

                 STTGGGTHHHHHHHHHHHHHHHHHHHHH CS
        EzrA 375 Selqeeleeleekleeieekqeeilesl 402
                   l++ +++lee + +++++ e+ ++ +
  EFC39236.1 948 AALNQAQKKLEEAIRDMKNEIEQREKII 975
                 *******************999877655 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.15
                  HHHHHHHHHHHHHHHHHHHHHHTTTTTTSHHHHHHHHHHHHHSTTS--SGGGSSSSSHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHHH CS
        EzrA  196 lkkleeeideleevieeiPelleelkkelpkqleelkegykemkeegYaleelniekeieelekkieeilerlkeleledveeelktieeeidsLyd 292 
                  +++l+++ ++l++ i ++ + l++ ++e+ ++ +e++    e+ ++g +le+       e+ + k +e   + ++ +++d ++el + +   d+L +
  EFC39236.1  989 IETLNKKAKDLDKRIADLENNLADSRNEINNKSNEISRLQMELSDQGIQLEN-------ESNNRKAREEDLKKRDKDIKDLKKELTDSQLAGDQLDS 1078
                  4555566666666666666666666666666666666666666666666655.......33333333333333344455555555555555555555 PP

                  HHHHHHHHHHHHTTTSSSSSHHHHT--HHHHTTGGG-TTTS-GGGS....STTTSTTHHHHHHHHHHHHHHHHHHHHHHS-SS---STTGGGTHHHH CS
        EzrA  293 dlekEveAkkeveknlkelkeklehlekqnkelkeeldrlkqsYeL....seeeleklrelekelkelekdyeeleekleekkvaYSelqeeleele 385 
                   l+k ++ k+  e+ l++ k+  ++l+++++ ++++ ++l+++ +      +   +k r+l+++l++ ++++++le+++++++    +lq e+++l+
  EFC39236.1 1079 ELKKTKKEKQGLEEDLDKQKKSADNLQRKLTATEQSAQNLSNQLDEetrkRQGAENKNRSLQSDLDNANSKVNDLENAVHDRDDLIAQLQAEINKLK 1175
                  55555555555555555555555555555555555555544432220000455678899************************************** PP

                  HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        EzrA  386 ekleeieekqeeileslkslrkdEkrAreqld 417 
                  ++++++e++ +++le  k+l+++ ++ + ++d
  EFC39236.1 1176 QRIADLESENQKLLERNKDLERELSDTKFRMD 1207
                  ****************9999887666665443 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 1.1
                  TTSSS-S---T.TTHHHHHHHHHHHHHHHHHHTHHHHHT-GGGT--S-SHHHHHTTHHHHHHHHHHHHHHHHHHHHHHHHTHHHHTTTTTHHHHHHH CS
        EzrA   46 lskvkklnltg.eseekfeewkkkwdeiktkklpeieellfeaeelldkykfkkakkklaeleeeldeveekikkileelkelteseeknreeiekl 141 
                  l+k+kk  +   +++++ ++++++ d+  +++ ++ +++ +++e ++ k +++++k++ ++l+++ld+ +e+++++ ++l++    +++  ++ ++l
  EFC39236.1 1246 LNKLKKADKDLkNLKKNKDDLQQEKDDADNRRNKDAQKKQTDLELQAAKDELNRTKQRADQLQTDLDNQKERANELESALSDTEGGKNQLDNQFKQL 1342
                  3444444443324444445555555555555555555555555555555555555555555555555555555555555555555555555555555 PP

                  HHHHHHHHHT--TTTTHHHHHHHHHHHH CS
        EzrA  142 kekYrelrkkllanrfsygealeelekq 169 
                  +++  + r+++++ + + ++ + +l++ 
  EFC39236.1 1343 QTDLNNERNNVNKLKTEAEKLQRQLDEA 1370
                  5555555555555555544444444443 PP

  == domain 4  score: 24.7 bits;  conditional E-value: 4.4e-09
                  SHHHHHHHHHHHHHHHHTT-..-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTSSSSSHHHHT--HHHHTTGGG-TTTS-GGGSSTTTSTTH CS
        EzrA  252 keieelekkieeilerlkel..eledveeelktieeeidsLyddlekEveAkkeveknlkelkeklehlekqnkelkeeldrlkqsYeLseeelekl 346 
                   e e+l+ +++e++ +l++   e  +  ++++ +ee+i +L  +le E  +k e +k+ ++  +++++l +q++ ++++l+   q+   +++  +++
  EFC39236.1 1358 TEAEKLQRQLDEATRALSDKssESSNLDAKVRALEEKIRELTALLESERSSKSESDKKKSKSDKEIKRLAEQLQGVESQLKSETQK---KNDADNRV 1451
                  6778899999999999865422677788999***********************************************99988887...899999** PP

                  HHHHHHHHHHHHHHHHHHHHHS-SS---STTGGGTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHS CS
        EzrA  347 relekelkelekdyeeleekleekkvaYSelqeeleeleekleeieekqeeileslkslrkdEkrAreqldeikkelkeikrki 430 
                  ++le+el++++++ ++l+++l++++   S  + +lee++ ++++++ +  ++ ++l++   d  +A eqld ++k+++++ +++
  EFC39236.1 1452 KQLENELNTVKNERDRLNKDLTNQSGDVSGAKRQLEEANTQIARLKADILKLTKDLQERDGDKDEADEQLDGLRKQIQDLTSRL 1535
                  ******************************************************************************998877 PP

  == domain 5  score: 2.6 bits;  conditional E-value: 0.022
                  HHHHHHHHHHHHHHHHHHHHHHHH.HHHHHHHTTTSSSSSHHHHT--HHHHTTGGG-TTTS-GGGSSTTTSTTHHHHHHHHHHHHHHHHHHHHHHS- CS
        EzrA  274 edveeelktieeeidsLyddlekE.veAkkeveknlkelkeklehlekqnkelkeeldrlkqsYeLseeeleklrelekelkelekdyeeleeklee 369 
                  +++e+e++ ++++i  L ddlekE ++ k+eve+ l+e  +  + l +q+k+++e++++lk                                    
  EFC39236.1 1550 QSIESENNRLKTDIARLRDDLEKEnKRLKQEVERVLAESDNDKNDLLTQLKKIQEQYSELK------------------------------------ 1610
                  3344445555555555555555552233444444444444444444444444444444444.................................... PP

                  SS---STTGGGTHH CS
        EzrA  370 kkvaYSelqeelee 383 
                           +e+++
  EFC39236.1 1611 ---------DEFKD 1615
                  .........44444 PP

>> Myosin_N  Myosin N-terminal SH3-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.4   1.8e-08   2.5e-05      11      38 ..      69      96 ..      60      98 .. 0.93
   2 ?   -3.2   0.2       5.6   7.7e+03      14      29 ..    1647    1662 ..    1647    1665 .. 0.89

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 1.8e-08
                TS-EEEEEEEEESSEEEEEETTSEEEEE CS
    Myosin_N 11 egyvkGeIkeeeGdkvtVetedGktvtV 38
                +++  GeIke++G +v+Vete+G ++t+
  EFC39236.1 69 NAFEVGEIKERKGKEVVVETESGDKKTL 96
                69************************97 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 5.6
                  EEEEEEEEESSEEEEE CS
    Myosin_N   14 vkGeIkeeeGdkvtVe 29  
                  +k+++ e ++  v+Ve
  EFC39236.1 1647 LKARVEEVTNQRVEVE 1662
                  5999*****9999998 PP

>> ADIP  Afadin- and alpha -actinin-Binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1       2.4   3.3e+03      42      91 ..     728     778 ..     728     818 .. 0.77
   2 ?   -1.6  18.2       1.8   2.5e+03      59     135 ..     853     929 ..     847     935 .. 0.66
   3 ?    1.8  22.7      0.17   2.3e+02      45     150 ..     895     996 ..     890     998 .. 0.58
   4 ?    0.9  23.9      0.32   4.4e+02      59     151 ..     958    1067 ..     951    1068 .. 0.44
   5 ?    1.5  23.5       0.2   2.8e+02      47     140 ..    1037    1130 ..    1036    1132 .. 0.97
   6 !   22.5  21.9     7e-08   9.6e-05      46     148 ..    1120    1222 ..    1116    1226 .. 0.97
   7 ?   -0.1   4.6      0.62   8.6e+02     113     149 ..    1226    1262 ..    1222    1265 .. 0.90
   8 ?   -0.7  14.7      0.96   1.3e+03      45     108 ..    1266    1329 ..    1264    1331 .. 0.93
   9 !    6.3  17.1    0.0066       9.2      55     139 ..    1332    1416 ..    1325    1419 .. 0.91
  10 ?    4.8  15.3      0.02        28      62     127 ..    1407    1474 ..    1397    1480 .. 0.78
  11 ?    4.6   6.1     0.024        33      53     114 ..    1484    1545 ..    1480    1547 .. 0.91
  12 ?    5.1  16.4     0.016        22      47     122 ..    1541    1617 ..    1540    1621 .. 0.86
  13 ?    1.4  12.2      0.22     3e+02      59     119 ..    1634    1694 ..    1629    1710 .. 0.84
  14 ?   -0.1  25.2      0.63   8.7e+02      67     140 ..    1825    1898 ..    1816    1914 .. 0.39

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.4
        ADIP  42 ysLlqardrdleqreslnetirkleaeierlqskierlk.tqleqlerela 91 
                 y+Ll+  +r leq+ +l  + + +  +i+  +++  +l  t++  ++++ a
  EFC39236.1 728 YDLLVEDKRSLEQQPNLRGKAQVILDSIKFEETTQYKLGaTKVFLKASQEA 778
                 799999999999999999999988888888887777776555555554444 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.8
        ADIP  59 netirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqklknekeelqrlknalqqiktqyahe 135
                 ++  +kl+ + e+l+++ e  k++ ++le+e  ++++  ++l  +l+++ + l +    ++ l++ l ++k  ++ +
  EFC39236.1 853 EQVTKKLKEDFEQLKKDLEGEKDSKKKLETEKNALEQSRKKLIDDLEEQRNRLDTMNNHMNQLEKELNDRKRELERS 929
                 55556667777777777777777777777777777777777777777777777777777777777777777665554 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.17
        ADIP  45 lqardrdleqreslnetirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqklknekeelqrlknalqqiktqyahelkkkdrei 143
                 +  +++ ++   ++n  +++le e+   + + er ++ + ++++e++  +++ + l++++k+le++++  k e++  +++++    +   +l  kd+ei
  EFC39236.1 895 IDDLEEQRNRLDTMNNHMNQLEKELNDRKRELERSQKDNDDKDSEITRNTQAIAALNQAQKKLEEAIRDMKNEIEQREKIIK----SKGGDLQNKDLEI 989
                 5555555555555555555555555555555555555555555555555555555555555555555555555555555544....4567889999999 PP

        ADIP 144 ekLkekl 150
                 e+L +k 
  EFC39236.1 990 ETLNKKA 996
                 9998876 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.32
        ADIP   59 netirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqkl.......knekeelqrlknalqqi..........ktqyahelkk 138 
                  +e ir++++eie+ ++ i++    l+ ++ e++++++k ++l k++++le+ l       +n++ e++rl++ l +           +++ + +lkk
  EFC39236.1  958 EEAIRDMKNEIEQREKIIKSKGGDLQNKDLEIETLNKKAKDLDKRIADLENNLadsrneiNNKSNEISRLQMELSDQgiqlenesnnRKAREEDLKK 1054
                  5555555555555555555544444444444444444444444444444433311111113333344444444444400000001113344567899 PP

        ADIP  139 kdreiekLkeklk 151 
                  +d+ i+ Lk+ l+
  EFC39236.1 1055 RDKDIKDLKKELT 1067
                  9999999998875 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.2
        ADIP   47 ardrdleqreslnetirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqklknekeelqrlknalqqiktqyahelkkkd 140 
                  +++ + + r++ +e+++k + +i+ l+++    +    ql++el+  +++++ le +l ++++ + n++++l+ +++ +q++++q+  e++k++
  EFC39236.1 1037 QLENESNNRKAREEDLKKRDKDIKDLKKELTDSQLAGDQLDSELKKTKKEKQGLEEDLDKQKKSADNLQRKLTATEQSAQNLSNQLDEETRKRQ 1130
                  57889999************************************************************************************97 PP

  == domain 6  score: 22.5 bits;  conditional E-value: 7e-08
        ADIP   46 qardrdleqreslnetirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqklknekeelqrlknalqqiktqyahelkkkdre 142 
                   ++d++ + r+  + ++r+l++++++ +sk++ l++ +++ +  +a++qa+ ++l++++++le+ ++++ e ++ l++ l ++k  +  elk k+ e
  EFC39236.1 1120 NQLDEETRKRQGAENKNRSLQSDLDNANSKVNDLENAVHDRDDLIAQLQAEINKLKQRIADLESENQKLLERNKDLERELSDTKFRMDEELKNKNNE 1216
                  6899********************************************************************************************* PP

        ADIP  143 iekLke 148 
                  i++Lk+
  EFC39236.1 1217 IDRLKK 1222
                  *****7 PP

  == domain 7  score: -0.1 bits;  conditional E-value: 0.62
        ADIP  113 nekeelqrlknalqqiktqyahelkkkdreiekLkek 149 
                  + k+el+ + n   + k+ + + lkk d+ ++ Lk++
  EFC39236.1 1226 SSKDELTLQLNRTNDEKNDLLNKLKKADKDLKNLKKN 1262
                  579999***************************9985 PP

  == domain 8  score: -0.7 bits;  conditional E-value: 0.96
        ADIP   45 lqardrdleqreslnetirkleaeierlqskierlktqleqlerelalvqakerqlekklktle 108 
                  lq+ + d++ r +  ++ ++ + e++  + + +r k++  ql++ l+ ++++ ++le +l ++e
  EFC39236.1 1266 LQQEKDDADNRRNKDAQKKQTDLELQAAKDELNRTKQRADQLQTDLDNQKERANELESALSDTE 1329
                  79999999999999******************************************99998875 PP

  == domain 9  score: 6.3 bits;  conditional E-value: 0.0066
        ADIP   55 reslnetirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqklknekeelqrlknalqqiktqyahelkkk 139 
                  +++l  + ++l++++ + ++++++lkt+ e+l+r+l+ +++++ +   +  +l++k++ + e+++ l   l++ + + + + kkk
  EFC39236.1 1332 KNQLDNQFKQLQTDLNNERNNVNKLKTEAEKLQRQLDEATRALSDKSSESSNLDAKVRALEEKIRELTALLESERSSKSESDKKK 1416
                  778999*************************************************************999998887777666666 PP

  == domain 10  score: 4.8 bits;  conditional E-value: 0.02
        ADIP   62 irkleaei..erlqskierlktqleqlerelalvqakerqlekklktleqklknekeelqrlknalqq 127 
                   +k e+++  ++  ++i+rl +ql+  e++l++ ++k++++  ++k+le+ l++ k e  rl+++l +
  EFC39236.1 1407 SSKSESDKkkSKSDKEIKRLAEQLQGVESQLKSETQKKNDADNRVKQLENELNTVKNERDRLNKDLTN 1474
                  4444444400455689**************************99999999888888888888777655 PP

  == domain 11  score: 4.6 bits;  conditional E-value: 0.024
        ADIP   53 eqreslnetirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqklkne 114 
                  +q e+ n++i +l+a+i +l+++ +  +    + + +l+ + ++ ++l+ +l ++++k ++e
  EFC39236.1 1484 RQLEEANTQIARLKADILKLTKDLQERDGDKDEADEQLDGLRKQIQDLTSRLGDANNKQQQE 1545
                  688999**********************99999999***************99999988877 PP

  == domain 12  score: 5.1 bits;  conditional E-value: 0.016
        ADIP   47 ardrdleqreslnetirkleaeierlqskierlktqleq.lerelalvqakerqlekklktleqklknekeelqrlk 122 
                  ++++++  r+s + ++++l+++i+rl+ + e+  ++l+q  er la + +++++l ++lk+ +++  ++k+e++ l+
  EFC39236.1 1541 KQQQEASSRQSIESENNRLKTDIARLRDDLEKENKRLKQeVERVLAESDNDKNDLLTQLKKIQEQYSELKDEFKDLQ 1617
                  68999***************************999998725777779999999999999999999999999876554 PP

  == domain 13  score: 1.4 bits;  conditional E-value: 0.22
        ADIP   59 netirkleaeierlqskierlktqleqlerelalvqakerqlekklktleqklknekeelq 119 
                  ++ +r+ e  +++l++++e +++q  + e++  +v+ ++++l+++l+t+e+  k+  ++ +
  EFC39236.1 1634 EKLRREYEMQLAQLKARVEEVTNQRVEVENKKRSVEMDLTELKTRLQTEERLRKKAEQQKK 1694
                  566677888899*************************************999988777655 PP

  == domain 14  score: -0.1 bits;  conditional E-value: 0.63
        ADIP   67 aeierlqskierlktqleqlerelalvqakerqlekklktleqklknekeelqrlknalqqiktqyahelkkkd 140 
                   +++ l++k  + +++++ l+++ ++  +k+++ e++  +le+ ++++k++l  l+ +l+++++q+  e kk +
  EFC39236.1 1825 RSKQDLEQKLTKTERENKLLQSQSQSDASKLQKSEQDKSKLEAENRQQKDKLLELQDDLEKLRQQVDSERKKTQ 1898
                  33333333333333333333333333333333333333333333333333333333333333333333333332 PP

>> Filament  Intermediate filament protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.3  48.7       7.6     1e+04      77     280 ..     856    1082 ..     840    1089 .. 0.65
   2 !   20.1  54.2   2.8e-07   0.00039      24     290 ..     969    1247 ..     969    1250 .. 0.81
   3 !    6.6  20.6    0.0037       5.2     202     282 ..    1281    1364 ..    1260    1369 .. 0.70
   4 ?    3.3  26.3     0.038        52      22     146 ..    1334    1471 ..    1332    1482 .. 0.81
   5 !    7.0  23.1    0.0028       3.8      63     184 ..    1479    1612 ..    1467    1619 .. 0.81
   6 !    7.8  23.9    0.0016       2.2      42     152 ..    1630    1736 ..    1625    1750 .. 0.85
   7 !    7.8  41.1    0.0016       2.2      25     149 ..    1754    1899 ..    1745    1905 .. 0.84

  Alignments for each domain:
  == domain 1  score: -4.3 bits;  conditional E-value: 7.6
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXX CS
    Filament   77 ldnlreeledlrkkyekelnkreevEaelkalr....kdldeatlarvdL...ekkvesLkeelaflkkvheeEvkelqkqvs....eqvlvevdaa 162 
                   ++l+e+ e+l+k +e e  +++++E e +al     k +d++  +r  L   ++++++L++el+ +k+  e   k+   + s    ++  +   ++
  EFC39236.1  856 TKKLKEDFEQLKKDLEGEKDSKKKLETEKNALEqsrkKLIDDLEEQRNRLdtmNNHMNQLEKELNDRKRELERSQKDNDDKDSeitrNTQAIAALNQ 952 
                  5789999999999999999999988888777765555566766655544411267899999999999998887777665554444365566666667 PP

                  XXXXXXXXXXXXXX...XXXXXXXX.....XXXXXX.XXXXXXXXXXXXXXXXXXXXXXX-HHHHHHHHHHHHHHHHHHHHH..HHHHHHHHHHHHH CS
    Filament  163 rkldLteilkeira...qyeelaek.....nreeae.ewykskleelqeaaeknsealrsakeeitelrrqiqsleielesl..kkqkasleaqlae 248 
                   +  L+e+++++++   q e+++++     +++++e e+ ++k ++l + ++  +++l  +++ei++   +i +l++el+++  + +++s +++ +e
  EFC39236.1  953 AQKKLEEAIRDMKNeieQREKIIKSkggdlQNKDLEiETLNKKAKDLDKRIADLENNLADSRNEINNKSNEISRLQMELSDQgiQLENESNNRKARE 1049
                  8888*********822245567765222223455555789999999999999999999999999999999999999999875224445555555444 PP

                  HH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament  249 le.erleaeleklqeklseleeelaeireemar 280 
                   + ++ ++++++l+++l++ + +  ++ +e+++
  EFC39236.1 1050 EDlKKRDKDIKDLKKELTDSQLAGDQLDSELKK 1082
                  331233444444444444333333333333333 PP

  == domain 2  score: 20.1 bits;  conditional E-value: 2.8e-07
                  XXXXXXXXXXXXXXXXXX..XXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament   24 EqenkeLeakieeleekk..saevsklkelyekeleelrkqldeltkerarlqleldnlreeledlrkkyekelnkreevEaelkalrkdldeatla 118 
                  Eq +k +++k  +l++k    ++ +k  +   k +++l ++l +  +e ++   e+++l++el d   ++e+e n+r++ E++lk+  kd++++  +
  EFC39236.1  969 EQREKIIKSKGGDLQNKDleIETLNKKAKDLDKRIADLENNLADSRNEINNKSNEISRLQMELSDQGIQLENESNNRKAREEDLKKRDKDIKDLKKE 1065
                  5666666666667776644344555666778899999999999999999999999999999999999999*******99999999999999999999 PP

                  XXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXX.XXX.X.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament  119 rvdLekkvesLkeelaflkkv...heeEvkelqkqvs.eqvlvevdaarkldLteilke.ira.q.yeelaeknreeaeewykskleelqeaaekns 208 
                   +d +   ++L  el+  kk     ee +++ +k++   q+++   +++ ++L++ l e  r+ q  e+  ++ +++++ + +sk+++l++a++  +
  EFC39236.1 1066 LTDSQLAGDQLDSELKKTKKEkqgLEEDLDKQKKSADnLQRKLTATEQSAQNLSNQLDEeTRKrQgAENKNRSLQSDLD-NANSKVNDLENAVHDRD 1161
                  99999999999999988776522268999999999888899999999999*******8723331313444444444555.5599************* PP

                  XXXXX-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH....HHHHHHHH CS
    Filament  209 ealrsakeeitelrrqiqsleieleslkkqkasleaqlaeleerleaeleklqeklseleeelaeireemarql....reYqeLLd 290 
                  + + + + ei++l+++i  le+e ++l + ++ le++l++++ r+++el++ ++++++l +  ++ ++e+  ql    +e ++LL+
  EFC39236.1 1162 DLIAQLQAEINKLKQRIADLESENQKLLERNKDLERELSDTKFRMDEELKNKNNEIDRLKKLSESSKDELTLQLnrtnDEKNDLLN 1247
                  **********************************************************9998888888876665111156666665 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.0037
                  XXXXXXXXXXXX-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
    Filament  202 eaaeknsealrsakeeitelrrqiqsleieleslkkqkasleaqlaele...erleaeleklqeklseleeelaeireemarql 282 
                   + ++ + +l++ak e++ ++++ ++l+++l+++k+ ++ le++l+++e   ++l+++ ++lq  l++  +++++++ e ++  
  EFC39236.1 1281 AQKKQTDLELQAAKDELNRTKQRADQLQTDLDNQKERANELESALSDTEggkNQLDNQFKQLQTDLNNERNNVNKLKTEAEKLQ 1364
                  334455557888999999999999999999999999999999999988733357778888888888888888888887655433 PP

  == domain 4  score: 3.3 bits;  conditional E-value: 0.038
                  XXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......XXXXXXXXXXXXXXX.. CS
    Filament   22 aLEqenkeLeakieeleekksaevsklkelyekeleelrkqldeltkerarlqleldnlreeledlrkkyeke.......lnkreevEaelkalr.. 109 
                  +L ++ k+L++ +++ +++ + + +   e  +++l+e+ ++l + ++e ++l++ ++ l+e++++l + +e+e        +k+++ ++e+k l   
  EFC39236.1 1334 QLDNQFKQLQTDLNNERNNVN-KLKTEAEKLQRQLDEATRALSDKSSESSNLDAKVRALEEKIRELTALLESErssksesDKKKSKSDKEIKRLAeq 1429
                  688999999999999999854.45557888999**************************************99888888844444455555555566 PP

                  .....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament  110 .....kdldeatlarvdLekkvesLkeelaflkkvheeEvke 146 
                        +l+ +t ++ d +++v++L++el+ +k+  +   k+
  EFC39236.1 1430 lqgveSQLKSETQKKNDADNRVKQLENELNTVKNERDRLNKD 1471
                  666669***************************987665555 PP

  == domain 5  score: 7.0 bits;  conditional E-value: 0.0028
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament   63 ldeltkerarlqleldnlreeledlrkkyekelnkreevEaelkalr..............kdldeatlarvdLekkvesLkeelaflkkvheeEvk 145 
                  +  ++++ + ++ ++ +l++++ +l k +++  ++++e++++l +lr               + +++  +r  +e++ + Lk ++a l+   e+E k
  EFC39236.1 1479 VSGAKRQLEEANTQIARLKADILKLTKDLQERDGDKDEADEQLDGLRkqiqdltsrlgdanNKQQQEASSRQSIESENNRLKTDIARLRDDLEKENK 1575
                  4455555566677777777888888888888888888888888888888888889999988555666679999************************ PP

                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament  146 elqkqvseqvlvevdaarkldLteilkeiraqyeelaek 184 
                   l+++v e+vl e d + k dL + lk i++qy el ++
  EFC39236.1 1576 RLKQEV-ERVLAESD-NDKNDLLTQLKKIQEQYSELKDE 1612
                  ******.9******9.678899999********998665 PP

  == domain 6  score: 7.8 bits;  conditional E-value: 0.0016
                  XXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament   42 saevsklkelyekeleelrkqldeltkerarlqleldnlreeledlrkkyekelnkreevEaelkalrkdldeatlarvdLekkvesLkeelaflkk 138 
                  saev+kl++ ye +l++l+++++e+t++r  ++   ++++++l +l++++++e ++r+++E++ k+   + de+     +L ++ e L++el+  k 
  EFC39236.1 1630 SAEVEKLRREYEMQLAQLKARVEEVTNQRVEVENKKRSVEMDLTELKTRLQTEERLRKKAEQQKKSAELECDEL----RELAEESEDLRDELNRNKL 1722
                  78999************************************************999999999877777666665....4888889999999998888 PP

                  XXXXXXXXXXXXXX CS
    Filament  139 vheeEvkelqkqvs 152 
                    ++ +++l++ + 
  EFC39236.1 1723 EQQALIQQLRTDLL 1736
                  88888888887765 PP

  == domain 7  score: 7.8 bits;  conditional E-value: 0.0016
                  XXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX............ CS
    Filament   25 qenkeLeakieeleekksaevsklkelyekeleelrkqldeltkerarlqleldnlreeledlrkkyekelnkreevEaelkalr............ 109 
                  +en+eL++ +e+ + k  ++ ++lk+ ye+el +l +q+ +++kera +  e++++  +l++++ ++++e ++++++E++l +              
  EFC39236.1 1754 RENEELKQDLEQERSKLDEAARRLKQQYENELLDLNNQVAQAKKERASASREQKKADRDLREFQRRLQEESRSKQDLEQKLTKTErenkllqsqsqs 1850
                  689*************999999***********************************************************99988999****9999 PP

                  .........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
    Filament  110 .........kdldeatlarvdLekkvesLkeelaflkkvheeEvkelqk 149 
                           +d  ++  +  +   k+ +L+++l+ l++  + E k++q+
  EFC39236.1 1851 dasklqkseQDKSKLEAENRQQKDKLLELQDDLEKLRQQVDSERKKTQR 1899
                  9966544332222333333333345557999999999999999998886 PP

>> ATG16  Autophagy protein 16 (ATG16)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8  20.7      0.02        28      99     182 ..     851     934 ..     841     935 .. 0.83
   2 !    7.1   6.1    0.0042       5.8     110     154 ..     932     976 ..     929     984 .. 0.92
   3 !    9.4  22.9   0.00084       1.2      89     184 ..     988    1090 ..     976    1093 .. 0.80
   4 !   19.8  24.5   5.2e-07   0.00072      86     187 ..    1090    1191 ..    1088    1195 .. 0.73
   5 ?   -1.2   7.9       1.5     2e+03     127     179 ..    1198    1251 ..    1195    1257 .. 0.68
   6 ?    3.6  40.4      0.05        69      25     178 ..    1243    1399 ..    1240    1400 .. 0.82
   7 !    8.0  24.6    0.0022       3.1      34     167 ..    1402    1535 ..    1397    1538 .. 0.77
   8 ?    2.5  20.8      0.11   1.5e+02      88     184 ..    1519    1616 ..    1516    1619 .. 0.93
   9 ?   -0.5  40.8      0.88   1.2e+03      34     160 ..    1763    1890 ..    1760    1902 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.02
       ATG16  99 elaqrllelneelqkleeklkedeerlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnqaEeklrklekENk 182
                  ++q  ++l+e  ++l++ l+ ++ + ++le+e++ale+ +k++ + l+e+++ ++++   +++L+ +ln +  +l++ +k+N 
  EFC39236.1 851 SSEQVTKKLKEDFEQLKKDLEGEKDSKKKLETEKNALEQSRKKLIDDLEEQRNRLDTMNNHMNQLEKELNDRKRELERSQKDND 934
                 566666788999999999999999999999999999999999999999999999999999999999999999999999999996 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0042
       ATG16 110 elqkleeklkedeerlaeleaeraaletklkdreeelrekeklvq 154
                   ++++++++++++++a+l++  ++le++++d ++e++++ek ++
  EFC39236.1 932 DNDDKDSEITRNTQAIAALNQAQKKLEEAIRDMKNEIEQREKIIK 976
                 57899************************************9986 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00084
       ATG16   89 elaelyksrgelaqrllelneelqkleeklkedeerlaeleaera....al...etklkdreeelrekeklvqdlqDElsaLqlqlnqaEeklrkle 178 
                  e ++l k+  +l +r+ +l++ l++ +++++++++++ +l+ e +    +l   + ++k ree l+ ++k ++dl+ El+  ql+  q++++l+k++
  EFC39236.1  988 EIETLNKKAKDLDKRIADLENNLADSRNEINNKSNEISRLQMELSdqgiQLeneSNNRKAREEDLKKRDKDIKDLKKELTDSQLAGDQLDSELKKTK 1084
                  6778888888888888888888888888888888888888776542222441114567889************************************ PP

       ATG16  179 kENkeL 184 
                  kE + L
  EFC39236.1 1085 KEKQGL 1090
                  **8876 PP

  == domain 4  score: 19.8 bits;  conditional E-value: 5.2e-07
       ATG16   86 lreelaelyksrgelaqrllelneelqkleeklkedeerlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnqaEeklrklekENk 182 
                  l e+l +  ks   l+ +l++++++ q l ++l e++++ + +e+++++l+  l++ + +++++e++v+d  D +++Lq + n++ ++  +le EN+
  EFC39236.1 1090 LEEDLDKQKKSADNLQRKLTATEQSAQNLSNQLDEETRKRQGAENKNRSLQSDLDNANSKVNDLENAVHDRDDLIAQLQAEINKLKQRIADLESENQ 1186
                  5677777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777 PP

       ATG16  183 eLveR 187 
                  +L+eR
  EFC39236.1 1187 KLLER 1191
                  77777 PP

  == domain 5  score: -1.2 bits;  conditional E-value: 1.5
       ATG16  127 eleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnqaEek..lrklek 179 
                  el++++ ++ ++lk++++e+  ++kl +  +DEl +Lql  +  E++  l+kl+k
  EFC39236.1 1198 ELSDTKFRMDEELKNKNNEIDRLKKLSESSKDEL-TLQLNRTNDEKNdlLNKLKK 1251
                  5666677788999999999999999999999997.45555544444322345555 PP

  == domain 6  score: 3.6 bits;  conditional E-value: 0.05
       ATG16   25 nrLldrtsaleaenaklekaaasakssksskksakekeasasq...snskqsakiqsleqklaqlreelaelyksrgelaqrllelneelqkleekl 118 
                  n+Ll++ ++ ++  ++l+k+  + +++k  + ++  k a+++q   + ++ +++++ ++q+  ql+++l +   + +el++ l +++    +l+++ 
  EFC39236.1 1243 NDLLNKLKKADKDLKNLKKNKDDLQQEKDDADNRRNKDAQKKQtdlELQAAKDELNRTKQRADQLQTDLDNQKERANELESALSDTEGGKNQLDNQF 1339
                  56666666666666666666555555333333333333333334567778999******************************************** PP

       ATG16  119 kedeerlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlqlnqaEeklrkle 178 
                  k+ ++ l++ ++++++l+t+ ++++ +l e ++++ d   E s L  ++  +Eek r+l+
  EFC39236.1 1340 KQLQTDLNNERNNVNKLKTEAEKLQRQLDEATRALSDKSSESSNLDAKVRALEEKIRELT 1399
                  *********************************************************996 PP

  == domain 7  score: 8.0 bits;  conditional E-value: 0.0022
       ATG16   34 leaenaklekaaasaks.sksskksakekeasasq......snskqsakiqsleqklaqlreelaelyksrgelaqrllelneelqkleeklkedee 123 
                  le+e+++        ++ +k+++ks+ke ++ a+q      + +++++k ++ +++++ql +el ++  +r  l++ l++ +  ++  +++l+e ++
  EFC39236.1 1402 LESERSSK-------SEsDKKKSKSDKEIKRLAEQlqgvesQLKSETQKKNDADNRVKQLENELNTVKNERDRLNKDLTNQSGDVSGAKRQLEEANT 1491
                  33333332.......22322222222222222222456776667788899999******************************************** PP

       ATG16  124 rlaeleaeraaletklkdreeelrekeklvqdlqDElsaLqlql 167 
                  ++a+l+a++ +l++ l++r+    e ++ ++ l+  ++ L+ +l
  EFC39236.1 1492 QIARLKADILKLTKDLQERDGDKDEADEQLDGLRKQIQDLTSRL 1535
                  ****************************9999999999887655 PP

  == domain 8  score: 2.5 bits;  conditional E-value: 0.11
       ATG16   88 eelaelyksrgelaqrllelneelqkleeklkedeerlaeleaeraaletklkdreeelr.ekeklvqdlqDElsaLqlqlnqaEeklrklekENke 183 
                  e+l  l k+ ++l++rl ++n++ q+  ++ ++ e++ ++l++++a+l++ l++ +++l+ e e+++ +   + + L  ql+++ e++ +l++E k+
  EFC39236.1 1519 EQLDGLRKQIQDLTSRLGDANNKQQQEASSRQSIESENNRLKTDIARLRDDLEKENKRLKqEVERVLAESDNDKNDLLTQLKKIQEQYSELKDEFKD 1615
                  7889999999******************************************9998888538899*****************************998 PP

       ATG16  184 L 184 
                  L
  EFC39236.1 1616 L 1616
                  8 PP

  == domain 9  score: -0.5 bits;  conditional E-value: 0.88
       ATG16   34 leaenaklekaaasaks.........sksskksakekeasasqsnskqsakiqsleqklaqlreelaelyksrgelaqrllelneelqkleeklked 121 
                  le+e++kl +aa + k+         +         + a+a+++ ++ s + ++ +  l + +  l+e  +s+++l+q+l++++ e + l++++++d
  EFC39236.1 1763 LEQERSKLDEAARRLKQqyenelldlN--------NQVAQAKKERASASREQKKADRDLREFQRRLQEESRSKQDLEQKLTKTERENKLLQSQSQSD 1851
                  677777777776666666543332321........2222222223345567788999999************************************* PP

       ATG16  122 eerlaeleaeraaletklkdreeelrekeklvqdlqDEl 160 
                  +++l++ e+++++le + ++++++l e++  +++l+  +
  EFC39236.1 1852 ASKLQKSEQDKSKLEAENRQQKDKLLELQDDLEKLRQQV 1890
                  *****************9999999999988888887654 PP

>> Fez1  Fez1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4  27.5      0.54   7.4e+02      35     154 ..     858     974 ..     840     979 .. 0.78
   2 !   17.5  29.2   3.3e-06    0.0045      23     166 ..     979    1130 ..     973    1139 .. 0.88
   3 !    6.9   7.2    0.0056       7.7      39     107 ..    1135    1203 ..    1131    1209 .. 0.76
   4 ?    2.1  26.0      0.17   2.3e+02      44     154 ..    1207    1321 ..    1204    1329 .. 0.73
   5 !   10.1  27.2   0.00058       0.8      36     171 ..    1335    1467 ..    1330    1472 .. 0.81
   6 !   18.2  22.7     2e-06    0.0027       6     147 ..    1473    1616 ..    1469    1622 .. 0.80
   7 ?   -1.5  34.5       2.1   2.8e+03      34     157 ..    1645    1776 ..    1628    1784 .. 0.61
   8 ?    1.9  33.3      0.19   2.7e+02      39     155 ..    1784    1901 ..    1777    1906 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.54
        Fez1  35 alkaqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelselsleeeeaalesdeakaqrqeaeeleel 133
                 +lk ++ +l+++le + ++ k+le++ +  +++ +++ ++l++++++ +++++++++le+el++ ++el++++++++++ +e +    + q+  +l++ 
  EFC39236.1 858 KLKEDFEQLKKDLEGEKDSKKKLETEKNALEQSRKKLIDDLEEQRNRLDTMNNHMNQLEKELNDRKRELERSQKDNDDKDSEIT---RNTQAIAALNQA 953
                 58889999999999999999999999999999999999999999999********************99997666555443333...355566778888 PP

        Fez1 134 kreverlraeLkeerqkkeeq 154
                 ++++e+  + +k+e +++e+ 
  EFC39236.1 954 QKKLEEAIRDMKNEIEQREKI 974
                 888888888888888888775 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 3.3e-06
        Fez1   23 qaevtqklseivalkaqlrelrakleekeeeikeleesleektlelevcenelqrk.......kseaellrekvekleeelkelreelselsleeee 112 
                    ++ +k  ei +l  + ++l +++ + e+++ + ++++++k++e+ +++ el+ +       +++ +  +e ++k ++++k+l++el++++l  ++
  EFC39236.1  979 GGDLQNKDLEIETLNKKAKDLDKRIADLENNLADSRNEINNKSNEISRLQMELSDQgiqleneSNNRKAREEDLKKRDKDIKDLKKELTDSQLAGDQ 1075
                  56899999**********************************************999999887777788888999***************9999999 PP

        Fez1  113 aalesdeakaqrqe.aeeleelkreverlraeLkeerqkkeeqassFeqERrtWq 166 
                    +e +++k+++q  +e+l++ k++ ++l+++L+  +q+ ++  ++ ++E r+ q
  EFC39236.1 1076 LDSELKKTKKEKQGlEEDLDKQKKSADNLQRKLTATEQSAQNLSNQLDEETRKRQ 1130
                  988888877777665789999*************************999976654 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0056
        Fez1   39 qlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelsels 107 
                  + r l+++l++ ++++++le++++++++ + ++++e+++ k++   l+ + +kl e  k+l +els+++
  EFC39236.1 1135 KNRSLQSDLDNANSKVNDLENAVHDRDDLIAQLQAEINKLKQRIADLESENQKLLERNKDLERELSDTK 1203
                  678889999999999999999999999999999999999977777777777777777777777776655 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.17
        Fez1   44 rakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelselsleeeeaalesdeakaqrqe........aeelee 132 
                   ++l++k++ei++l++ +e+ ++el     +l+r+++e++ l +k++k++++lk+l+++  +l++e+++a ++ ++  aq+++        ++el++
  EFC39236.1 1207 DEELKNKNNEIDRLKKLSESSKDEL---TLQLNRTNDEKNDLLNKLKKADKDLKNLKKNKDDLQQEKDDADNRRNK-DAQKKQtdlelqaaKDELNR 1299
                  679999********99999988885...56899999999999999***********99888876665555433322.23333335666666777777 PP

        Fez1  133 lkreverlraeLkeerqkkeeq 154 
                   k++ ++l++ L +++++ +e 
  EFC39236.1 1300 TKQRADQLQTDLDNQKERANEL 1321
                  7777888888888777776665 PP

  == domain 5  score: 10.1 bits;  conditional E-value: 0.00058
        Fez1   36 lkaqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelselsleeeeaalesdeakaqrqeaeelee 132 
                  l +q+++l+++l+++ +++++l++++e+ +++l++    l+ k+se+++l+ kv++lee+++el   l++      ++++esd  k++ ++ +e+++
  EFC39236.1 1335 LDNQFKQLQTDLNNERNNVNKLKTEAEKLQRQLDEATRALSDKSSESSNLDAKVRALEEKIRELTALLESER----SSKSESD--KKKSKSDKEIKR 1425
                  67899********************************************************99999776633....3333344..455555678999 PP

        Fez1  133 lkreverlraeLkeerqkkee...qassFeqERrtWqeeKek 171 
                  l ++++ ++++Lk e qkk++   ++++ e+E +t ++e+++
  EFC39236.1 1426 LAEQLQGVESQLKSETQKKNDadnRVKQLENELNTVKNERDR 1467
                  999999999999999888765111567888888888888887 PP

  == domain 6  score: 18.2 bits;  conditional E-value: 2e-06
        Fez1    6 cQksGEislLKqQLkdsqaevtqklseivalkaqlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelree 102 
                    +sG++s  K QL ++ +++++   +i++l  +l+e   + +e +e+++ l++++++ t  l   +n+ q++ s+ + ++ + ++l++++++lr++
  EFC39236.1 1473 TNQSGDVSGAKRQLEEANTQIARLKADILKLTKDLQERDGDKDEADEQLDGLRKQIQDLTSRLGDANNKQQQEASSRQSIESENNRLKTDIARLRDD 1569
                  6689********************************************************************************************* PP

        Fez1  103 lselsleeeeaa....lesdeakaqrqeaeeleelkreverlraeLkee 147 
                  l++ +++ ++++    +esd+ k+     ++l++ +++  +l+ e k  
  EFC39236.1 1570 LEKENKRLKQEVervlAESDNDKND--LLTQLKKIQEQYSELKDEFKDL 1616
                  *997766555543333222222222..2345555555555555555543 PP

  == domain 7  score: -1.5 bits;  conditional E-value: 2.1
        Fez1   34 valkaqlrelrakleekeeeikele...esleektlelevcenelqrkkseaellrekvekleeelkelreelselsleeeeaa....lesdeakaq 123 
                   +lka++ e++++  e e++ +++e   ++l+++ +  e++ ++ +++k++ael  +++++l ee ++lr+el++++le++  +    ++  + ++q
  EFC39236.1 1645 AQLKARVEEVTNQRVEVENKKRSVEmdlTELKTRLQTEERLRKKAEQQKKSAELECDELRELAEESEDLRDELNRNKLEQQALIqqlrTDLLQERNQ 1741
                  4566666666555544444444444111344455555566666666668888888888888888888888888887777766664444333344555 PP

        Fez1  124 rqe.aeeleelkreverlraeLkeerqkkeeqass 157 
                  r++  e +++ +re e+l++ L++er k +e a  
  EFC39236.1 1742 RASaDEVSSRVRRENEELKQDLEQERSKLDEAARR 1776
                  55523445667888899999999998887766554 PP

  == domain 8  score: 1.9 bits;  conditional E-value: 0.19
        Fez1   39 qlrelrakleekeeeikeleesleektlelevcenelqrkkseaellrekvekleeelkelreelselsle.eeeaalesdeakaqrqeaeeleelk 134 
                  +l +l++++ +  +e  +++ + ++ +++l + + +lq+++ +++ l++k++k+e+e k l+++ ++ +++ +++++ +s+   ++rq++++l el+
  EFC39236.1 1784 ELLDLNNQVAQAKKERASASREQKKADRDLREFQRRLQEESRSKQDLEQKLTKTERENKLLQSQSQSDASKlQKSEQDKSKLEAENRQQKDKLLELQ 1880
                  66788999999999999999999999999******************************9988665544440444445555556779999******* PP

        Fez1  135 reverlraeLkeerqkkeeqa 155 
                   ++e+lr+++  er+k+++ a
  EFC39236.1 1881 DDLEKLRQQVDSERKKTQRLA 1901
                  ***************998875 PP

>> SKA2  Spindle and kinetochore-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   8.6       3.6     5e+03      43      94 ..     859     914 ..     852     940 .. 0.44
   2 ?   -3.1  11.3         5   6.8e+03      43      96 ..    1076    1126 ..    1036    1140 .. 0.79
   3 ?    1.7   9.1      0.15   2.1e+02      39      92 ..    1163    1223 ..    1133    1243 .. 0.51
   4 ?   -2.6  11.8       3.5   4.8e+03      41     100 ..    1243    1302 ..    1230    1325 .. 0.72
   5 ?   -0.7   9.8      0.88   1.2e+03      11     103 ..    1321    1416 ..    1315    1425 .. 0.82
   6 !    6.1   7.8    0.0067       9.2      16      96 ..    1428    1508 ..    1423    1522 .. 0.78
   7 ?    1.2   3.2      0.22   3.1e+02      52     104 ..    1491    1547 ..    1483    1554 .. 0.64
   8 !   18.3   5.1   1.1e-06    0.0015      12      67 ..    1564    1619 ..    1553    1627 .. 0.88
   9 ?   -2.0   7.2       2.2   3.1e+03      53     106 ..    1643    1696 ..    1630    1700 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 3.6
        SKA2  43 LlerlkkvkeelqaLkeqceellaekk...elidkirttlvanrellqqLqasa.e 94 
                 L e+++++k++l+  k+  ++l +ek    ++ +k+   l ++r+ l  +++++ +
  EFC39236.1 859 LKEDFEQLKKDLEGEKDSKKKLETEKNaleQSRKKLIDDLEEQRNRLDTMNNHMnQ 914
                 33333333333333333333333333333323333333344444444444444432 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 5
        SKA2   43 LlerlkkvkeelqaLkeqceellaekkelidkirttlvanrellqqLqasa.elp 96  
                  L ++lkk k+e q L+e++     ++k+++d ++++l a+ +  q+L +++ e +
  EFC39236.1 1076 LDSELKKTKKEKQGLEEDL----DKQKKSADNLQRKLTATEQSAQNLSNQLdEET 1126
                  5567777777777777775....5799**********************996332 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.15
        SKA2   39 NpvkLlerlkkvkeelqaLkeqceellaekk.......elidkirttlvanrellqqLqas 92  
                    ++L ++++k+k++++ L+++ ++ll++ k       ++  ++   l +  + + +L++ 
  EFC39236.1 1163 LIAQLQAEINKLKQRIADLESENQKLLERNKdlerelsDTKFRMDEELKNKNNEIDRLKKL 1223
                  3445555555555555555555555555555111111155555555555555555555544 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 3.5
        SKA2   41 vkLlerlkkvkeelqaLkeqceellaekkelidkirttlvanrellqqLqasa.elpplse 100 
                    Ll++lkk  ++l++Lk++ ++l++ek +  ++ ++   + +++  +Lqa+  el+ +++
  EFC39236.1 1243 NDLLNKLKKADKDLKNLKKNKDDLQQEKDDADNRRNKDA-QKKQTDLELQAAKdELNRTKQ 1302
                  579*************************97766655555.555555566666655555553 PP

  == domain 5  score: -0.7 bits;  conditional E-value: 0.88
        SKA2   11 FqkaesdLdyvqhrLekefqqsypdna...eNpvkLlerlkkvkeelqaLkeqceellaekkelidkirttlvanrellqqLqasaelpplseeeq 103 
                  +++a sd +  +++L+ +f+q   d     +N+ kL ++ +k++++l +  + + + ++e  +l  k+r+   + rel+  L+ +   +++s++ +
  EFC39236.1 1321 LESALSDTEGGKNQLDNQFKQLQTDLNnerNNVNKLKTEAEKLQRQLDEATRALSDKSSESSNLDAKVRALEEKIRELTALLESERSSKSESDKKK 1416
                  6777777788889********998866678999999999999999999999999999999999999999999999999888887776666655444 PP

  == domain 6  score: 6.1 bits;  conditional E-value: 0.0067
        SKA2   16 sdLdyvqhrLekefqqsypdnaeNpvkLlerlkkvkeelqaLkeqceellaekkelidkirttlvanrellqqLqasa.....elp 96  
                  ++L+ v+++L++e q++ + +   + +L ++l+ vk+e   L++++    +++   ++ ++++l +  + + +L+a++      l+
  EFC39236.1 1428 EQLQGVESQLKSETQKKNDADN-RVKQLENELNTVKNERDRLNKDL----TNQSGDVSGAKRQLEEANTQIARLKADIlkltkDLQ 1508
                  57999*************9995.8999999********99999985....678888888999999999999999888874332222 PP

  == domain 7  score: 1.2 bits;  conditional E-value: 0.22
        SKA2   52 eelqaLkeqceel...laekkelidkirttlvanrellqqLqasaelppls.eeeqe 104 
                  ++++ Lk+++ +l   l+e+    d++  +l + r+ +q+L  +++   ++ ++e  
  EFC39236.1 1491 TQIARLKADILKLtkdLQERDGDKDEADEQLDGLRKQIQDLTSRLGDANNKqQQEAS 1547
                  55555555555551112456667899999**************99544444255554 PP

  == domain 8  score: 18.3 bits;  conditional E-value: 1.1e-06
        SKA2   12 qkaesdLdyvqhrLekefqqsypdnaeNpvkLlerlkkvkeelqaLkeqceellae 67  
                   +   dL+  ++rL++e+++ ++++ ++   Ll++lkk++e++++Lk+++++l+++
  EFC39236.1 1564 ARLRDDLEKENKRLKQEVERVLAESDNDKNDLLTQLKKIQEQYSELKDEFKDLQKQ 1619
                  55667999999**************99999***********************987 PP

  == domain 9  score: -2.0 bits;  conditional E-value: 2.2
        SKA2   53 elqaLkeqceellaekkelidkirttlvanrellqqLqasaelpplseeeqeaa 106 
                  +l++Lk+++ee+ +++ e+ +k r+  ++ +el ++Lq +  l  + e+ +++a
  EFC39236.1 1643 QLAQLKARVEEVTNQRVEVENKKRSVEMDLTELKTRLQTEERLRKKAEQQKKSA 1696
                  467899999999999999999999988899999999988887777776665555 PP

>> Laminin_II  Laminin Domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       3.2   4.5e+03      42      87 ..     211     259 ..     193     267 .. 0.74
   2 ?   -2.8  13.9       4.2   5.8e+03       9      95 ..     853     947 ..     850     954 .. 0.63
   3 ?   -1.8  12.0       2.1   2.9e+03      12      95 ..     941    1027 ..     932    1034 .. 0.77
   4 !    7.4   5.5    0.0031       4.2       8      58 ..    1076    1126 ..    1069    1135 .. 0.89
   5 ?    2.5   9.3     0.096   1.3e+02      32      85 ..    1135    1188 ..    1127    1223 .. 0.67
   6 ?    3.1   4.4     0.066        91      14      71 ..    1285    1342 ..    1274    1342 .. 0.78
   7 !   17.1   9.5   3.1e-06    0.0042      16      86 ..    1336    1406 ..    1329    1415 .. 0.91
   8 !    7.2   7.0    0.0035       4.8      27      84 ..    1417    1474 ..    1406    1481 .. 0.80
   9 !    5.8  10.1    0.0097        13       9     104 ..    1469    1568 ..    1461    1572 .. 0.85
  10 ?    0.7   8.4      0.35   4.8e+02      11      81 ..    1541    1612 ..    1537    1638 .. 0.53
  11 ?    2.6   7.6     0.094   1.3e+02       4      87 ..    1577    1663 ..    1572    1676 .. 0.79
  12 ?   -2.6   9.3       3.7   5.1e+03       2      79 ..    1648    1721 ..    1647    1737 .. 0.76
  13 !    6.5   4.5    0.0056       7.8       5      59 ..    1742    1797 ..    1738    1801 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 3.2
                 XXXXXXXXXXXXXXXXXXXXXXX--TT...TTTGGGHHHHHHHHHH... CS
  Laminin_II  42 etnekvkdankairdArrsvkkLekla...pqLldklkelkqleeasss 87 
                 e ++k+ ++ +a++ A++   kLe+++   + Ll+ + + k+l++++ss
  EFC39236.1 211 ENTKKIIQYLTATAGASHGAGKLENQLlqtNPLLEAFGNAKTLRNNNSS 259
                 4566677788888888888888888653336688888888888888776 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 4.2
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH...........HHHHHHHH CS
  Laminin_II   9 netakevleqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelkqleeasss........lsdnisei 95 
                 ++ +k+ +e+ ++l+++le +k++ ++++++ +  ++  k++   +++ r+   ++++ ++qL++ l+  k   e s+         + +n + i
  EFC39236.1 853 EQVTKKLKEDFEQLKKDLEGEKDSKKKLETEKNALEQSRKKLIDDLEEQRNRLDTMNNHMNQLEKELNDRKRELERSQKdnddkdseITRNTQAI 947
                 56788999999999999999999999999885555555555555555556666667777777776665554444443322222333566665555 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 2.1
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH.......HHHHHHHH CS
  Laminin_II   12 akevleqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelkqleeasss....lsdnisei 95  
                  + ++ + +a+l+q  ++++e +  +++++e+ ++ +k++   ++    ++ +L+k+a +L +++  l++    s +     s++is++
  EFC39236.1  941 TRNT-QAIAALNQAQKKLEEAIRDMKNEIEQREKIIKSKGGDLQNKDLEIETLNKKAKDLDKRIADLENNLADSRNeinnKSNEISRL 1027
                  4444.44577888888999999999999999999999999999999999999999999999999999988777766644445555554 PP

  == domain 4  score: 7.4 bits;  conditional E-value: 0.0031
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  Laminin_II    8 anetakevleqlaplsqnlentkeklseinrsveetnekvkdankairdAr 58  
                   ++ +k++++ +++l+++l++ k+++ +++r++  t++ ++++++++++  
  EFC39236.1 1076 LDSELKKTKKEKQGLEEDLDKQKKSADNLQRKLTATEQSAQNLSNQLDEET 1126
                  578899*************************************99998755 PP

  == domain 5  score: 2.5 bits;  conditional E-value: 0.096
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH. CS
  Laminin_II   32 klseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelkqleeas 85  
                  k  ++++++++ n kv+d+ +a+ d  + + +L+ ++++L +++  l+  +++ 
  EFC39236.1 1135 KNRSLQSDLDNANSKVNDLENAVHDRDDLIAQLQAEINKLKQRIADLESENQKL 1188
                  455677777777777777777777777777777777777777777766544432 PP

  == domain 6  score: 3.1 bits;  conditional E-value: 0.066
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTT CS
  Laminin_II   14 evleqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqL 71  
                  ++   l++ + +l++tk+ + ++++++++ +e ++++  a+ d +    +L+++  qL
  EFC39236.1 1285 QTDLELQAAKDELNRTKQRADQLQTDLDNQKERANELESALSDTEGGKNQLDNQFKQL 1342
                  4555567778889999999999999999999999999999999988888888877665 PP

  == domain 7  score: 17.1 bits;  conditional E-value: 3.1e-06
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH.. CS
  Laminin_II   16 leqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelkqleeass 86  
                   +q ++l+++l+n++++++++++++e+ + ++++a++a+ d ++++++L+ ++  L++k++el  l e + 
  EFC39236.1 1336 DNQFKQLQTDLNNERNNVNKLKTEAEKLQRQLDEATRALSDKSSESSNLDAKVRALEEKIRELTALLESER 1406
                  578899*********************************************************99877644 PP

  == domain 8  score: 7.2 bits;  conditional E-value: 0.0035
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH CS
  Laminin_II   27 entkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelkqleea 84  
                  ++  +++++++++++ ++ ++k+ ++  +dA + vk+Le++++ + +   +l++   +
  EFC39236.1 1417 SKSDKEIKRLAEQLQGVESQLKSETQKKNDADNRVKQLENELNTVKNERDRLNKDLTN 1474
                  45566788888888888888***********************998877778777666 PP

  == domain 9  score: 5.8 bits;  conditional E-value: 0.0097
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH.......HHHHHHHHHHHHHH CS
  Laminin_II    9 netakevleqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelkqleeasss....lsdniseikelIaq 101 
                  n+ +++   ++ + + +le+ + ++ ++++++ + ++++++     ++A ++   L k++++L ++l   ++++++++s    +  + +++k  Ia+
  EFC39236.1 1469 NKDLTNQSGDVSGAKRQLEEANTQIARLKADILKLTKDLQERDGDKDEADEQLDGLRKQIQDLTSRLGDANNKQQQEASsrqsIESENNRLKTDIAR 1565
                  666666777888899999*************************************************999888887766677888888999999988 PP

                  HHH CS
  Laminin_II  102 ARk 104 
                   R+
  EFC39236.1 1566 LRD 1568
                  886 PP

  == domain 10  score: 0.7 bits;  conditional E-value: 0.35
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHH CS
  Laminin_II   11 takevleqlaplsqnlentkeklseinrsveetnekvk.dankairdArrsvkkLeklapqLldklkelkql 81  
                  + ++  +  + ++ + +++k ++ ++++++e+ n+ +k +  +++++  +   +L  ++ ++ ++ +elk  
  EFC39236.1 1541 KQQQEASSRQSIESENNRLKTDIARLRDDLEKENKRLKqEVERVLAESDNDKNDLLTQLKKIQEQYSELKDE 1612
                  444445555555556666666666666666666666653333444444444445555555555555555443 PP

  == domain 11  score: 2.6 bits;  conditional E-value: 0.094
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXX..XXXXXX--TTTTTGGGHHHHHHHHHH... CS
  Laminin_II    4 laaeanetakevleqlaplsqnlentkeklseinrsveetnekvk.dankairdAr..rsvkkLeklapqLldklkelkqleeasss 87  
                  l +e++  ++e  +++++l ++l++++e++se++++ +  +++ +     ++++A+  +  ++ e+++ qL ++++e+ +++++ ++
  EFC39236.1 1577 LKQEVERVLAESDNDKNDLLTQLKKIQEQYSELKDEFKDLQKQPRgGVAGGVDSAEveKLRREYEMQLAQLKARVEEVTNQRVEVEN 1663
                  556788888999999*********************999999888667777777752145678899999999999999999998766 PP

  == domain 12  score: -2.6 bits;  conditional E-value: 3.7
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHH CS
  Laminin_II    2 kelaaeanetakevleqlaplsqnlentkeklseinrsveetnekvkdankairdArrsvkkLeklapqLldklkelk 79  
                  k+ ++e+ ++ +ev++++  ++ +l ++k  l++ +r      +k+++ +k  ++  ++ ++L ++ ++L d l++ k
  EFC39236.1 1648 KARVEEVTNQRVEVENKKRSVEMDLTELKTRLQTEERL----RKKAEQQKKSAELECDELRELAEESEDLRDELNRNK 1721
                  67788999999999999999999999999888776655....788888888888888888888888888888876533 PP

  == domain 13  score: 6.5 bits;  conditional E-value: 0.0056
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXX CS
  Laminin_II    5 aaeanetakevleqlaplsqnlentkeklseinrsveet.nekvkdankairdArr 59  
                   a+a+e  + v +  ++l+q+le++++kl e++r +++  ++++ d+n+++++A++
  EFC39236.1 1742 RASADEVSSRVRRENEELKQDLEQERSKLDEAARRLKQQyENELLDLNNQVAQAKK 1797
                  579*******************************9875415567788888888875 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6  34.8   0.00028      0.38     138     279 ..     853    1000 ..     849    1002 .. 0.83
   2 ?    1.2  17.2       0.1   1.4e+02     163     260 ..     990    1083 ..     981    1085 .. 0.68
   3 ?   12.9  32.3   2.6e-05     0.037     143     283 ..    1082    1225 ..    1074    1229 .. 0.86
   4 ?    7.0  35.1    0.0017       2.3     138     281 ..    1225    1366 ..    1222    1366 .. 0.89
   5 ?    8.1  20.5    0.0008       1.1     171     283 ..    1334    1438 ..    1332    1441 .. 0.55
   6 ?   11.5  24.5   7.5e-05       0.1     143     270 ..    1425    1548 ..    1415    1571 .. 0.52
   7 ?    7.6  28.7    0.0011       1.6     139     282 ..    1565    1717 ..    1558    1725 .. 0.62
   8 ?   -1.5  35.0      0.67   9.3e+02     148     274 ..    1728    1858 ..    1719    1860 .. 0.85
   9 ?   -2.1  19.4         1   1.4e+03     177     246 ..    1828    1900 ..    1827    1910 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00028
        Spc7  138 egLkegleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeeles...idkeeLeelreelaelkaeieekkkelaelqeqlee 231 
                  e++ ++l+e +e+l++d e  ++++++l++ +++le+ +++l + le+++++ + +++     ++eL+  ++el++ +++ + k  e+++ ++ +++
  EFC39236.1  853 EQVTKKLKEDFEQLKKDLEGEKDSKKKLETEKNALEQSRKKLIDDLEEQRNRLDTMNNhmnQLEKELNDRKRELERSQKDNDDKDSEITRNTQAIAA 949 
                  677888999999999999999999999999999988888887777777777666666653233789******************************* PP

        Spc7  232 leekieelkeqkseleeeiaeaervleeckg...wsesevsrlkeevkale 279 
                  l+++ ++l+e ++++++ei++ e++++ + g    ++ e+++l+++ k+l+
  EFC39236.1  950 LNQAQKKLEEAIRDMKNEIEQREKIIKSKGGdlqNKDLEIETLNKKAKDLD 1000
                  **************************9998622244558888888888876 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.1
        Spc7  163 eeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeaervlee 259 
                  e l++  ++l+++ a+le++l++ +++ ++    +++e+  l+ el+++  ++e+ +++ + ++e+l++ +++i++lk++ ++ + +  + ++ l++
  EFC39236.1  990 ETLNKKAKDLDKRIADLENNLADSRNEINN----KSNEISRLQMELSDQGIQLENESNNRKAREEDLKKRDKDIKDLKKELTDSQLAGDQLDSELKK 1082
                  334444444444444444444444443333....688999999999999999999999999999999999999999998888887777766666665 PP

        Spc7  260 c 260 
                  +
  EFC39236.1 1083 T 1083
                  5 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 2.6e-05
        Spc7  143 gleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeeles...idkeeLeelreelaelkaeieekkkelaelqeqleeleeki 236 
                  + +++ +gleed ++ +k+ ++l++ l ++e+  ++l+++l+++ ++++  e+   + + +L ++ +++++l++ ++ + + +a+lq+++++l+++i
  EFC39236.1 1082 KTKKEKQGLEEDLDKQKKSADNLQRKLTATEQSAQNLSNQLDEETRKRQGAENknrSLQSDLDNANSKVNDLENAVHDRDDLIAQLQAEINKLKQRI 1178
                  44667788888888888888888888888888888999999888876555555433669************************************** PP

        Spc7  237 eelkeqkseleeeiaeaervleeckgwsesevsrlkeevkaleeltg 283 
                  ++l+++ ++l e+ +  er l  +k   ++e+++ ++e ++l++l++
  EFC39236.1 1179 ADLESENQKLLERNKDLERELSDTKFRMDEELKNKNNEIDRLKKLSE 1225
                  *****************************************999875 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.0017
        Spc7  138 egLkegleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeeles..idkeeLeelreelaelkaeieekkkelaelqeqleel 232 
                  e+ k++l+ +l+  +++k+ L ++ +++d+ l++l+++k++l++e ++  +++++ ++   +  eL+++++el++ k+  ++++++l++ +e+ +el
  EFC39236.1 1225 ESSKDELTLQLNRTNDEKNDLLNKLKKADKDLKNLKKNKDDLQQEKDDADNRRNKDAQkkQTDLELQAAKDELNRTKQRADQLQTDLDNQKERANEL 1321
                  5568899999999***********************************9997666555224477899****************************** PP

        Spc7  233 eekieelkeqkseleeeiaeaervleeckgwsesevsrlkeevkaleel 281 
                  e+++++++  k++l ++ ++ +  l+     ++++v++lk+e ++l+++
  EFC39236.1 1322 ESALSDTEGGKNQLDNQFKQLQTDLN----NERNNVNKLKTEAEKLQRQ 1366
                  *******************9988888....56789***********985 PP

  == domain 5  score: 8.1 bits;  conditional E-value: 0.0008
        Spc7  171 eleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeia...eaervleeckgws 264 
                  +l++++++l+  l++++           +++++l+ e ++l+ +++e  + l+++ ++  +l++k+ +l+e+++el + ++   ++++  +++k+ s
  EFC39236.1 1334 QLDNQFKQLQTDLNNER-----------NNVNKLKTEAEKLQRQLDEATRALSDKSSESSNLDAKVRALEEKIRELTALLEserSSKSESDKKKSKS 1419
                  44444444444444444...........455555555555555555555555555555555555555555555554444430004556677889999 PP

        Spc7  265 esevsrlkeevkaleeltg 283 
                  ++e++rl e+++ +e++++
  EFC39236.1 1420 DKEIKRLAEQLQGVESQLK 1438
                  9999999999999988765 PP

  == domain 6  score: 11.5 bits;  conditional E-value: 7.5e-05
        Spc7  143 gleenlegleedkelLekqeeeldellpeleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieel 239 
                  +l e+l+g+e++ +  +++++ +d+ +++le+e +++++e ++l++  +     ++ ++  ++++l+e++++i+++k+++ +l+++l+e + + +e+
  EFC39236.1 1425 RLAEQLQGVESQLKSETQKKNDADNRVKQLENELNTVKNERDRLNKDLT----NQSGDVSGAKRQLEEANTQIARLKADILKLTKDLQERDGDKDEA 1517
                  4555556666666666666666666666666666666666666665222....23555555555555555555555555555555555555555555 PP

        Spc7  240 keqkseleeeiaeaervleeckgwsesevsr 270 
                  +eq + l+++i+   + l    + +++e s+
  EFC39236.1 1518 DEQLDGLRKQIQDLTSRLGDANNKQQQEASS 1548
                  5555555555555555444444444444333 PP

  == domain 7  score: 7.6 bits;  conditional E-value: 0.0011
        Spc7  139 gLkegleenlegleedke.lLekqeeeldell...peleeekaeleeeleklqeaaeeles..idkeeLeelreelaelkaeieekkkelaelqeql 229 
                   L++ le++ + l+++ e +L+++ +  ++ll   ++++e+++el++e+++lq++ +   +  +d++e+e+lr+e + + a+++++ +e+++ + ++
  EFC39236.1 1565 RLRDDLEKENKRLKQEVErVLAESDNDKNDLLtqlKKIQEQYSELKDEFKDLQKQPRGGVAggVDSAEVEKLRREYEMQLAQLKARVEEVTNQRVEV 1661
                  5777888888888877651455555555555400045566777899999999986665544569*********987766666664444444444444 PP

        Spc7  230 eeleekie.elkeqks..eleeeiaeaervleeckgwsesevsrlkeevkaleelt 282 
                  e+++ ++e +l+e k+  ++ee+++++ + +++  + + +e+++l ee ++l +++
  EFC39236.1 1662 ENKKRSVEmDLTELKTrlQTEERLRKKAEQQKKSAELECDELRELAEESEDLRDEL 1717
                  44444443223333330033455666666666677778889999999988887765 PP

  == domain 8  score: -1.5 bits;  conditional E-value: 0.67
        Spc7  148 legleedkelLekqeeeldellpeleeekaeleeeleklqe....aaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelk 240 
                  +++l++d  +  +q++ +de+  ++++e +el++ le++++    aa+ l++  ++eL  l +++a++k+e ++ ++e ++  ++l e + +++e +
  EFC39236.1 1728 IQQLRTDLLQERNQRASADEVSSRVRRENEELKQDLEQERSkldeAARRLKQQYENELLDLNNQVAQAKKERASASREQKKADRDLREFQRRLQEES 1824
                  566777777777788888888888888877766666665554444999999999******************************************* PP

        Spc7  241 eqkseleeeiaeaervleeckgwsesevsrlkee 274 
                   +k++le+++ + er  +  ++ s+s+ s+l+++
  EFC39236.1 1825 RSKQDLEQKLTKTERENKLLQSQSQSDASKLQKS 1858
                  ***************************9999875 PP

  == domain 9  score: -2.1 bits;  conditional E-value: 1
        Spc7  177 aeleeeleklqeaaeeles...idkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqksel 246 
                  ++le++l+k +++++ l+s   +d  +L++  ++ ++l+ae +++k++l elq++le+l++++++ +++ ++l
  EFC39236.1 1828 QDLEQKLTKTERENKLLQSqsqSDASKLQKSEQDKSKLEAENRQQKDKLLELQDDLEKLRQQVDSERKKTQRL 1900
                  4455555555554444433333899999999999999999999999999999999999999998777666655 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.1     0.001       1.4      10      40 ..     196     226 ..     188     242 .. 0.86
   2 ?   -1.6   2.4       2.3   3.1e+03      43      78 ..     942    1011 ..     926    1200 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.001
      AAA_19  10 ekvllvtaGpGtGKTrvlkhivallvelggv 40 
                 ++ +lvt+  G GKT+ +k+i+++l ++ g 
  EFC39236.1 196 NQSMLVTGESGAGKTENTKKIIQYLTATAGA 226
                 6789********************9988765 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 2.3
      AAA_19   43 eeillvaftgrAakelrerlaalgae.....................atTiHrlal.............l 78  
                  ++  ++a  ++A k+l+e+++ ++ e                     ++T+ + a               
  EFC39236.1  942 RNTQAIAALNQAQKKLEEAIRDMKNEieqrekiikskggdlqnkdleIETLNKKAKdldkriadlennlA 1011
                  5666788888999999999999988866666666666666666666655555554444444433333330 PP

>> BRI3BP  Negative regulator of p53/TP53
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   0.2       7.7   1.1e+04     160     177 ..     991    1008 ..     986    1010 .. 0.71
   2 ?   10.0   0.1   0.00034      0.47     154     176 ..    1377    1399 ..    1368    1402 .. 0.84
   3 ?    0.2   0.7      0.33   4.5e+02     149     177 ..    1435    1463 ..    1424    1466 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 7.7
      BRI3BP  160 sleakvrsLerqvrelnk 177 
                  +l++k + L++++  l+ 
  EFC39236.1  991 TLNKKAKDLDKRIADLEN 1008
                  577777788888777765 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00034
      BRI3BP  154 seesgasleakvrsLerqvreln 176 
                  +++++++l+akvr Le+++rel 
  EFC39236.1 1377 KSSESSNLDAKVRALEEKIRELT 1399
                  34799****************96 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.33
      BRI3BP  149 lyaksseesgasleakvrsLerqvrelnk 177 
                  +  ks++++++  +++v++Le++++ ++ 
  EFC39236.1 1435 SQLKSETQKKNDADNRVKQLENELNTVKN 1463
                  456778899999***********998865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1917 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3855  (0.215015); expected 358.6 (0.02)
Passed bias filter:                      840  (0.0468515); expected 358.6 (0.02)
Passed Vit filter:                       533  (0.0297284); expected 17.9 (0.001)
Passed Fwd filter:                       213  (0.0118802); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 9.83u 0.47s 00:00:10.30 Elapsed: 00:00:01.72
# Mc/sec: 3374.04
//
Query:       EFC39237.1  [L=612]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.9e-35  119.7  30.2    2.1e-08   33.7   1.0   10.5  9  DUF4116        Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.14   11.6   0.0        0.5    9.8   0.0    2.1  1  Clathrin-link  Clathrin, heavy-chain linker


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.5   0.6   6.8e-08   0.00061      22      45 ..      59      82 ..      30      85 .. 0.84
   2 !   17.6   0.0   2.6e-07    0.0023       1      32 [.      88     119 ..      88     159 .. 0.91
   3 !   16.2   0.4     7e-07    0.0062       6      49 .]     168     210 ..     163     210 .. 0.88
   4 !   19.2   1.1   8.1e-08   0.00073       1      49 []     188     242 ..     188     242 .. 0.91
   5 !    5.6   0.3    0.0014        13      14      31 ..     232     249 ..     219     252 .. 0.84
   6 !   20.2   0.1   4.1e-08   0.00037       6      35 ..     250     279 ..     250     295 .. 0.91
   7 !    6.0   0.1    0.0011       9.8      14      29 ..     507     522 ..     487     527 .. 0.76
   8 !   26.3   0.3     5e-10   4.5e-06       8      36 ..     525     553 ..     523     554 .. 0.87
   9 !   33.7   1.0   2.4e-12   2.1e-08       1      38 [.     543     580 ..     543     595 .. 0.85

  Alignments for each domain:
  == domain 1  score: 19.5 bits;  conditional E-value: 6.8e-08
     DUF4116 22 eLknDkeivlkAvkqngtalsyas 45
                ++knD++++l+ vk +g++l+y++
  EFC39237.1 59 SYKNDRDLILQSVKHHGNILNYVD 82
                4688******************96 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 2.6e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 D E++ ea+k+++s + +l++++ ++ +++l+
  EFC39237.1  88 DPELIFEALKTCPSMISKLPPSHLKNTDFALR 119
                 89********************9999999885 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 7e-07
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + ++++ g+ l+ +s++ + D+e+vl A+++ ++ +++ase L+
  EFC39237.1 168 KIVLSRKGFLLELFSDKDREDIELVLCAMQIPKY-FKFASERLQ 210
                 67899*************************6666.999999886 PP

  == domain 4  score: 19.2 bits;  conditional E-value: 8.1e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngt.......alsyaseeLr 49 
                 D E+vl a+++ ++++k++se+L+n  +++  +  ++++       +++y+ +eL+
  EFC39237.1 188 DIELVLCAMQI-PKYFKFASERLQNSEQFASCIFSIYSSnslfgvnSFPYIIPELK 242
                 89********9.799******************99999767788878999999997 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.0014
     DUF4116  14 salkylseeLknDkeivl 31 
                 +++ y+ +eLkn++ +++
  EFC39237.1 232 NSFPYIIPELKNNFTFMK 249
                 5999**********9997 PP

  == domain 6  score: 20.2 bits;  conditional E-value: 4.1e-08
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvk 35 
                 l ++k n+s +k++s+eL+ ++e+++ +++
  EFC39237.1 250 LSCLKFNPSLFKHASPELRGNIEFIKCIIN 279
                 689***********************9987 PP

  == domain 7  score: 6.0 bits;  conditional E-value: 0.0011
     DUF4116  14 salkylseeLknDkei 29 
                  +l+y+s+e+k D  +
  EFC39237.1 507 PILQYASDEIKDDLSF 522
                 5899******999776 PP

  == domain 8  score: 26.3 bits;  conditional E-value: 5e-10
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkq 36 
                 a++  +++++y+se+L+++ke+v+k v +
  EFC39237.1 525 ALTYLPCCIQYASEKLRSNKEFVKKVVMK 553
                 556669*******************9976 PP

  == domain 9  score: 33.7 bits;  conditional E-value: 2.4e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 ++E+v+++v k+ + ++y+se ++nD e+vl+ +   +
  EFC39237.1 543 NKEFVKKVVMKDDNMFQYASETIRNDYEFVLELLIEKK 580
                 79******************************987544 PP

>> Clathrin-link  Clathrin, heavy-chain linker
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   5.6e-05       0.5      12      24 .]     111     123 ..     109     123 .. 0.93

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 5.6e-05
  Clathrin-link  12 LnNpdLALrlAsR 24 
                    L+N+d ALr+AsR
     EFC39237.1 111 LKNTDFALRMASR 123
                    99**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (612 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       642  (0.0358079); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 3719.05
//
Query:       EFC39238.1  [L=367]
Description: 24-sterol C-methyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-24   86.5   0.2      2e-24   85.6   0.2    1.5  1  Sterol_MT_C      Sterol methyltransferase C-terminal
    5.7e-12   45.5   0.3    8.1e-12   45.0   0.3    1.1  1  CMAS             Mycolic acid cyclopropane synthetase
    1.5e-11   44.8   0.0    2.6e-11   44.0   0.0    1.4  1  Methyltransf_11  Methyltransferase domain
    3.9e-09   36.5   0.0    5.6e-09   36.0   0.0    1.3  1  Methyltransf_31  Methyltransferase domain
    1.6e-08   35.1   0.0      4e-08   33.8   0.0    1.7  2  Methyltransf_25  Methyltransferase domain
    1.9e-07   31.7   0.0    2.9e-06   27.9   0.0    2.2  2  Methyltransf_12  Methyltransferase domain
    2.4e-07   30.7   0.0    5.6e-07   29.5   0.0    1.6  1  Methyltransf_23  Methyltransferase domain
  ------ inclusion threshold ------
       0.07   12.9   0.0       0.11   12.2   0.0    1.3  1  PCMT             Protein-L-isoaspartate(D-aspartate) O-methyl


Domain annotation for each model (and alignments):
>> Sterol_MT_C  Sterol methyltransferase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.6   0.2   9.1e-28     2e-24       1      66 []     298     363 ..     298     363 .. 0.98

  Alignments for each domain:
  == domain 1  score: 85.6 bits;  conditional E-value: 9.1e-28
  Sterol_MT_C   1 ltvfrmtkvGrfithnlvkvleflglapkGtqkvaefLekAadsLvaGGkegiFTPmylfvaRKPl 66 
                  +t++  t++Grfi+h+lv++le +gl+pk +q+  efL ++a +LvaGGk+giFTP+y+f+aRKPl
   EFC39238.1 298 FTSWFQTSYGRFIVHKLVGILESVGLVPKSSQQAYEFLMAGASGLVAGGKTGIFTPCYFFMARKPL 363
                  7999*************************************************************6 PP

>> CMAS  Mycolic acid cyclopropane synthetase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.0   0.3   3.6e-15   8.1e-12       8     218 ..      62     276 ..      53     282 .. 0.83

  Alignments for each domain:
  == domain 1  score: 45.0 bits;  conditional E-value: 3.6e-15
                 HHHHHHHTS-HHHHCTTS-TT---S----SSTT--HHHHHHHHHHHHHTTTT--TT-EEEEES-TTSHHHHHHHHHH--EEEEEES-HHHHHHHHHHHH CS
        CMAS   8 enikahYDlsndffalfldptmtYsCAyferddmtLeeAqlaKldlileklelkpGmtlLdiGcGWGslvrraverydvkvvglTlSkeqaklakkrvd 106
                 +   + YD+  df+    +++  ++    ++++  +e+ q++ + l  ++++lk+Gm+ Ld+GcG  + +++  +  ++++ g+     q ++ak+ + 
  EFC39238.1  62 DVAGKYYDMVTDFYLYGWGRSFHFA--PRHKKESMIESIQRHEYWL-AKQMDLKKGMKCLDLGCGVMGPATNISRFTGAHITGVNNHPYQSQQAKEYIS 157
                 5556789999999988877777664..4455566699999998865.689***************999888888888********************** PP

                 TS-SSS-EEEEES-GGG---.......--SEEEEES-GGGTSGGGHHHHHHHHHHHS-TT-EEEEEEEEE--HHHHHCTTCCCHHHHHHTSTTS---BH CS
        CMAS 107 eldlerkvevklldyedlde.......kvdrvvsvgafehvgkenydtffkklkkllkedGllllhtitslhkkelaerglklkfidkeiFPgGelpsi 198
                 +++l+++ ++   d+++ld+        +d+  +++a  h + +  ++ +k+++++lk++ +++    ++ + k  ++++ + + i+ +i  g  lp+i
  EFC39238.1 158 QMGLSEQCQIVRGDFNNLDDnsdlpseSYDAAYTIEASCHAKDR--PHCYKQIYNKLKPGAIFAGYEWVMISGKYDSKNEEH-NKIKFDIMKGDGLPEI 253
                 ******************99888877789999999998886554..67789************9988888777766644433.67999*****99**98 PP

                 ...HHHHHHHHHTT-EEEEEEE- CS
        CMAS 199 ...eeieeeiseagftvvdvesl 218
                    +ei+e+ ++agf+v+++e +
  EFC39238.1 254 lmdKEIDESLRKAGFEVIKTEDV 276
                 55578************998865 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.0   1.1e-14   2.6e-11       1      94 [.     118     218 ..     118     220 .. 0.91

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 1.1e-14
                      EEET-TTSHHHHHHHHTT.SEEEEEES-HHHHHHHHHHCCHHT-..EEEETTEECCCTS....S-TT-EEEEEEES-CCC-CCHHHHHHHHHHH CS
  Methyltransf_11   1 LdvGcGtGrlaealakrg.arvvgvDlskemlklakekaseegl..kvefvvadaeklp....fednsfDlvvssevlhhvedpekalkeiaRv 87 
                      Ld+GcG    a  + +   a+++gv+  +++ ++ake +s+ gl  ++++v++d+ +l     ++++s+D+ +  e+ +h +d+ ++ k+i+  
       EFC39238.1 118 LDLGCGVMGPATNISRFTgAHITGVNNHPYQSQQAKEYISQMGLseQCQIVRGDFNNLDdnsdLPSESYDAAYTIEASCHAKDRPHCYKQIYNK 211
                      8*****7777777775555***************************9*********8744666******************************* PP

                      EEEEEEE CS
  Methyltransf_11  88 LkpgGll 94 
                      Lkpg ++
       EFC39238.1 212 LKPGAIF 218
                      ****987 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.0   0.0   2.5e-12   5.6e-09       2     108 ..     112     219 ..     111     267 .. 0.80

  Alignments for each domain:
  == domain 1  score: 36.0 bits;  conditional E-value: 2.5e-12
  Methyltransf_31   2 dkglrvlDlGCGtGeltfelaeelgpkaevvGiDiseeaielArenaqklgld.nveFeqgdieelekl..ledekfDlilsnevlnaladpdk 92 
                      +kg++ lDlGCG    + ++    +++a+++G+ + +   ++A+e  ++ gl+  ++  +gd+++l+ +  l  e++D   + e+ ++ +d + 
       EFC39238.1 112 KKGMKCLDLGCGVMGPATNIS--RFTGAHITGVNNHPYQSQQAKEYISQMGLSeQCQIVRGDFNNLDDNsdLPSESYDAAYTIEASCHAKDRPH 203
                      79**********844444444..4789******************9999**999***********765426777******************** PP

  Methyltransf_31  93 ileeiervlkpggill 108
                      ++++i + lkpg i++
       EFC39238.1 204 CYKQIYNKLKPGAIFA 219
                      **********999886 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       6.8   1.5e+04      73      91 ..      81     100 ..      67     101 .. 0.72
   2 !   33.8   0.0   1.8e-11     4e-08       2      96 ..     118     215 ..     117     215 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 6.8
                      T.GGGSSHHHHHHHHHHHHH CS
  Methyltransf_25  73 a.lhhlsdedlekalkeiar 91 
                        +h+ ++++ e +++ i r
       EFC39238.1  81 RsFHFAPRHKKESMIESIQR 100
                      44777777888888888877 PP

  == domain 2  score: 33.8 bits;  conditional E-value: 1.8e-11
                      EEET-TTSHHHHHHHCTSTSSEEEEEESSHHHHHHHHHHHHHTTT..TEEEEESBCCGBS....SSTTTEEEEEEESTGGGSSHHHHHHHHHHH CS
  Methyltransf_25   2 LdlGcGtGrltlalakrlgkakvtgvDiseemleaareraeeegl..nvefvqgdaedlp....fedgsfDlvvssgalhhlsdedlekalkei 89 
                      LdlGcG    + ++++  g a++tgv   + + ++a+e +++ gl  ++++v+gd+++l+    ++++s+D+ + + a +h   +d+++++k+i
       EFC39238.1 118 LDLGCGVMGPATNISRFTG-AHITGVNNHPYQSQQAKEYISQMGLseQCQIVRGDFNNLDdnsdLPSESYDAAYTIEASCH--AKDRPHCYKQI 208
                      9******999999998877.**********************99999*********99975555699********887554..57999****** PP

                      HHHEEEE CS
  Methyltransf_25  90 arvLkpg 96 
                      ++ Lkpg
       EFC39238.1 209 YNKLKPG 215
                      ******8 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.24   5.4e+02      44      74 ..      31      75 ..      21     100 .. 0.75
   2 !   27.9   0.0   1.3e-09   2.9e-06       1      98 [.     118     217 ..     118     218 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.24
  Methyltransf_12 44 ennnnnnvelealdlldldgg...............ssfDlvvasn 74
                     + + n+nv+ + +dl+ +d +               +++D+v+ + 
       EFC39238.1 31 H-LTNENVTGTYQDLFAQDTKdthdkrknagwdvagKYYDMVTDFY 75
                     4.45667777777777777777777788888999999999999765 PP

  == domain 2  score: 27.9 bits;  conditional E-value: 1.3e-09
  Methyltransf_12   1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvelealdlldldgg.....ssfDlvvasnvlhhlkdirevldni 89 
                      L++GcG+   +  + +   ++++tgv  +p + ++ake +++ +     ++++   d  +ld++     +s+D+ + +++ +h kd+    ++i
       EFC39238.1 118 LDLGCGVMGPATNISRF-TGAHITGVNNHPYQSQQAKEYISQMGLSE--QCQIVRGDFNNLDDNsdlpsESYDAAYTIEASCHAKDRPHCYKQI 208
                      89****99999999666.9********************99988643..55555555555555555667************************* PP

  Methyltransf_12  90 rklLkpgGr 98 
                      ++ Lkpg++
       EFC39238.1 209 YNKLKPGAI 217
                      *******87 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.5   0.0   2.5e-10   5.6e-07      19     164 ..     108     272 ..      88     273 .. 0.72

  Alignments for each domain:
  == domain 1  score: 29.5 bits;  conditional E-value: 2.5e-10
  Methyltransf_23  19 k..lraggrvLdiGcGtG.illevlrengfsvtgvDlspeaveiae................kakkaqkdqfdeqeaae..........pqgkf 83 
                         l++g+++Ld+GcG+    +++ r  g+++tgv   p +++ a+                +               +          p++++
       EFC39238.1 108 QmdLKKGMKCLDLGCGVMgPATNISRFTGAHITGVNNHPYQSQQAKeyisqmglseqcqivrG---------------DfnnlddnsdlPSESY 186
                      24479999********9725555555559**********999998776666666533333321...............02222223445778** PP

  Methyltransf_23  84 dlIvlrevlehvpdppellrqiatllkpgGylllse....plaslkedrllldwlylvpagrhi.sffsarslkelleeaGlevve 164
                      d ++ +e  +h +d p+  +qi++ lkpg+ +   e    ++++++ ++   +++++  +g+ +      +++ e l++aG+ev++
       EFC39238.1 187 DAAYTIEASCHAKDRPHCYKQIYNKLKPGAIFAGYEwvmiSGKYDSKNEEHNKIKFDIMKGDGLpEILMDKEIDESLRKAGFEVIK 272
                      *****************************99887774443566666666667777766666555477777*************985 PP

>> PCMT  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0     5e-05      0.11      67     132 ..     107     171 ..      88     205 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5e-05
                 HHTT--TT-EEEEES-TTSHHHHHHHHHHCTTCEEEEEESBHHHHHHHHHHHHHCTTC.SEEEEES- CS
        PCMT  67 ellelkkgarvLevGsGsGyltavlarlvgekgrvvsierikelveeakrnlkkldle.nvivvvgD 132
                 + ++lkkg++ L++G+G    +  ++r+ g++    +++  +   ++ak+ + + +l+ + ++v gD
  EFC39238.1 107 KQMDLKKGMKCLDLGCGVMGPATNISRFTGAHI--TGVNNHPYQSQQAKEYISQMGLSeQCQIVRGD 171
                 4567*************9889999999999876..9******************9998789999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (367 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       714  (0.0398237); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2242.11
//
Query:       EFC39239.1  [L=528]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (528 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1776  (0.0990574); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 3138.10
//
Query:       EFC39240.1  [L=184]
Description: hypothetical protein NAEGRDRAFT_52589 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.5e-12   45.7   0.2    8.2e-12   45.4   0.2    1.1  1  EF-hand_7     EF-hand domain pair
    3.8e-11   42.0   0.1    0.00027   20.6   0.0    2.2  2  EF-hand_6     EF-hand domain
    9.9e-10   37.3   0.1     0.0017   17.8   0.0    2.2  2  EF-hand_1     EF hand
    1.2e-06   28.3   0.5    3.1e-05   23.7   0.2    1.7  2  EF-hand_8     EF-hand domain pair
    0.00014   22.1   0.1    0.00019   21.7   0.1    1.1  1  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
  ------ inclusion threshold ------
      0.026   14.0   0.0        3.9    7.1   0.0    2.3  2  EF-hand_5     EF hand
      0.094   12.0   0.3       0.12   11.6   0.3    1.0  1  DUF2813       Protein of unknown function (DUF2813)
        2.2    8.6  41.4        3.5    7.9  41.4    1.5  1  Pro-rich      Proline-rich


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.4   0.2   3.7e-15   8.2e-12       3      70 ..      11      70 ..       9      71 .. 0.91

  Alignments for each domain:
  == domain 1  score: 45.4 bits;  conditional E-value: 3.7e-15
   EF-hand_7  3 klkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlkly 70
                + ++++ ++D+d++g l k e++++++        g +  ++e ++lfk++D d++ vi+++EFl++y
  EFC39240.1 11 QAQQVYYQYDKDRNGVLKKKEFKKAMQ------ALGAH--KDECKHLFKMVDVDHNKVITMNEFLNAY 70
                7789999********************......78888..45699********************998 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   1.2e-07   0.00027       3      31 .]      13      40 ..      11      40 .. 0.90
   2 !   19.4   0.0   2.9e-07   0.00064       3      26 ..      47      70 ..      45      76 .. 0.91

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.2e-07
   EF-hand_6  3 reaFklfDkdgdGkidaeElrkalrkalg 31
                ++++ ++Dkd++G + ++E++ka++ alg
  EFC39240.1 13 QQVYYQYDKDRNGVLKKKEFKKAMQ-ALG 40
                577889******************9.887 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 2.9e-07
   EF-hand_6  3 reaFklfDkdgdGkidaeElrkal 26
                +++Fk+ D+d++  i+++E+ +a+
  EFC39240.1 47 KHLFKMVDVDHNKVITMNEFLNAY 70
                799*****************9986 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   7.4e-07    0.0017       8      28 ..      18      38 ..      12      39 .. 0.90
   2 !   17.5   0.0   9.2e-07    0.0021       1      25 [.      45      69 ..      45      70 .. 0.93

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 7.4e-07
                HHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1  8 efDkDgdGkIdfeEfkellkk 28
                 +DkD++G + ++Efk+++++
  EFC39240.1 18 QYDKDRNGVLKKKEFKKAMQA 38
                69*****************97 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 9.2e-07
                HHHHHHHHHTTTSSSEEEHHHHHHH CS
   EF-hand_1  1 elkeiFrefDkDgdGkIdfeEfkel 25
                e+k +F+++D+D++  I+ +Ef+++
  EFC39240.1 45 ECKHLFKMVDVDHNKVITMNEFLNA 69
                68999*****************976 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.6   0.0   0.00037      0.83      36      53 ..      20      37 ..      17      39 .. 0.89
   2 !   23.7   0.2   1.4e-08   3.1e-05       2      51 ..      24      69 ..      23      71 .. 0.91

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00037
   EF-hand_8 36 DtdgdGkisfeEFcvlle 53
                D d++G+++++EF   ++
  EFC39240.1 20 DKDRNGVLKKKEFKKAMQ 37
                99************9998 PP

  == domain 2  score: 23.7 bits;  conditional E-value: 1.4e-08
   EF-hand_8  2 kgkItreelrrilrilglkkglseeevdilfrefDtdgdGkisfeEFcvl 51
                +g++ + e+++++ +lg      ++e+ +lf+ +D d++ +i+ +EF++ 
  EFC39240.1 24 NGVLKKKEFKKAMQALG----AHKDECKHLFKMVDVDHNKVITMNEFLNA 69
                69999********7778....67************************986 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.1   8.5e-08   0.00019      49     111 ..       5      67 ..       2      69 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 8.5e-08
  SPARC_Ca_bdg  49 lkeckepvawkFsklDtnsdkvlsksELaplraplvklehCikpflescDadkdkkislkEwc 111
                    ++++++++  + + D+++++vl+k+E ++  + l  +    k++++  D+d++k i+++E+ 
    EFC39240.1   5 GQMYSSQAQQVYYQYDKDRNGVLKKKEFKKAMQALGAHKDECKHLFKMVDVDHNKVITMNEFL 67 
                   57899999999*****************9988889887777799*****************97 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0    0.0018       3.9       7      23 ..      18      34 ..      17      36 .. 0.90
   2 ?    4.7   0.0      0.01        23       3      21 ..      48      66 ..      47      72 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0018
                HH-SS-SSCE-HHHHHH CS
   EF-hand_5  7 aiDlNgDGkIskeELkt 23
                + D+++ G + k E+k+
  EFC39240.1 18 QYDKDRNGVLKKKEFKK 34
                79*************97 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.01
                HHHHHH-SS-SSCE-HHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeEL 21
                ++F+++D+++   I++ E+
  EFC39240.1 48 HLFKMVDVDHNKVITMNEF 66
                68*******9988888888 PP

>> DUF2813  Protein of unknown function (DUF2813)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.3   5.3e-05      0.12      71     133 ..      10      69 ..       2      73 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.3e-05
     DUF2813  71 ekhlqlvltfkeeekeeekarrykklsavwvkekdgleriyyrvsgelnedekvttersFlde 133
                 +++ q+   + +++++  k++++kk  +++  +kd++++++  v+ + n   kv+t  +Fl++
  EFC39240.1  10 SQAQQVYYQYDKDRNGVLKKKEFKKAMQALGAHKDECKHLFKMVDVDHN---KVITMNEFLNA 69 
                 55667888999999******************************98877...*********96 PP

>> Pro-rich  Proline-rich
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9  41.4    0.0016       3.5      64     142 ..      95     180 ..       4     184 .] 0.63

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0016
    Pro-rich  64 e.......nkpeqgpppqggpqqrPpqgg.kkkpqgPPpqggpqrpp..PG...kpqgPPpqggnqqrrppqPggkpqgpppqgppkqggpk 142
                 +       + ++   p+qg pqq Ppq+g  ++p g P  g pq+p   PG   ++q  Ppqg +qq  ppq g  +q pp+qg+      +
  EFC39240.1  95 TtttttmmGGQPGMMPQQGYPQQYPPQQGyPQQPYGQPGMGYPQQPYgqPGmmpQQQQYPPQGYPQQ-YPPQQGYPQQYPPQQGGY-----P 180
                 0444444445555679999999955555504566666777777776544532225666677777775.666666556666666533.....3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (184 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       827  (0.0461264); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 1141.03
//
Query:       EFC39241.1  [L=574]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.9e-19   68.3   6.1    7.9e-19   68.3   6.1    2.3  2  TLD             TLD
    1.3e-10   41.3  32.3    7.2e-06   26.1   2.9    4.6  4  Pentapeptide_4  Pentapeptide repeats (9 copies)
    2.3e-05   24.4  24.1    7.9e-05   22.7   1.2    5.1  5  Pentapeptide_3  Pentapeptide repeats (9 copies)
    4.1e-05   23.1  14.0        0.1   12.3   0.8    5.7  5  Pentapeptide    Pentapeptide repeats (8 copies)
    5.3e-05   23.5   0.1    0.00019   21.7   0.1    2.0  1  BTB_2           BTB/POZ domain


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.2      0.98   3.5e+03     103     121 ..     248     269 ..     221     284 .. 0.51
   2 !   68.3   6.1   2.2e-22   7.9e-19       1     138 [.     409     570 ..     409     571 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.98
         TLD 103 slekgtsrhs...etfenglls 121
                 ++e+ t++++     f+n+ l 
  EFC39241.1 248 QFESVTFEKCtiqMHFKNNNLK 269
                 3333333333333334443333 PP

  == domain 2  score: 68.3 bits;  conditional E-value: 2.2e-22
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnk..kfygdsesflfsl......spkfkvyks..tgknkaylntssdglgf 89 
                 lly+ ++dg+ ++ +++k++n+g tl++ik+e++++fGaf+sq+wks+++  +f+ d++ f+f++      + +++ ++   ++k++a+  ++++   f
  EFC39241.1 409 LLYRGTRDGFHANDFHSKCDNQGATLTIIKSEHNQVFGAFTSQSWKSNKDnfNFVMDDSAFIFKIvtdhngNYQVQHFNInqNKKQYAIEAHHKYLVIF 507
                 69*******************************************5444445899*************999555555555225555555566666699* PP

         TLD  90 Gggqp...kfsLwidsslek.gtsrhsetfengllsg..........aseerfkikdiEVWgl 138
                 Gg+ +   ++ ++ d +l++ ++s+   t+e +   +          a+  +fk+ +iEV+++
  EFC39241.1 508 GGTTEiegDICIYSDCNLNNaSYSNFGLTYELPTGYNygtdeaksylAGCYTFKVIEIEVFKI 570
                 **999*666666667788884555566666655444445666677999999*********986 PP

>> Pentapeptide_4  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.1   2.9     2e-09   7.2e-06       3      74 ..     195     265 ..     193     268 .. 0.66
   2 !   15.1   5.4   5.2e-06     0.019       3      52 ..     263     314 ..     261     316 .. 0.86
   3 !   12.8   6.7   2.8e-05       0.1       7      63 ..     318     374 ..     315     380 .. 0.64
   4 ?    0.2   0.1      0.23   8.3e+02       6      22 ..     518     534 ..     516     537 .. 0.68

  Alignments for each domain:
  == domain 1  score: 26.1 bits;  conditional E-value: 2e-09
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsdklkd 74 
                     ++r+    ++l++ +   +++r+ n++++++++  F++c++s+v   + ++k+a+F+ ++++++++ +++k+
      EFC39241.1 195 LRRVIVQHVNLAGKEIIGFDFRGMNLVDVNFKASYFKDCHFSNVA-IGSQFKKAQFESVTFEKCTIQMHFKN 265
                     555555566666666666666666666666666666666666654.36699999999999999999877665 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 5.2e-06
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrl...snvnFdecnlsdvdfaevd 52 
                     f++  ++nck+ +++F+ + ++ +nF+ + l   +n    +c+++++d++e++
      EFC39241.1 263 FKNNNLKNCKCIECEFNGSVFEKANFKLIELvltTNN-SFNCLIKNTDLREMR 314
                     99999**********************9999874444.458*******99975 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 2.8e-05
  Pentapeptide_4   7 sfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnl 63 
                     +f++ k++ + F  ++l + +++++ + n n+d  +ls+  f +  ++++sF ++ l
      EFC39241.1 318 KFKGFKFDSCLFDFSKLSNKQINSIMFENINLDAQDLSTFIFINSTFAHTSFAHVKL 374
                     566666666666666666666666666777777777777777777777777766665 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.23
  Pentapeptide_4   6 csfnncklsnvnFsear 22 
                     c + +c+l+n+++s++ 
      EFC39241.1 518 CIYSDCNLNNASYSNFG 534
                     66777777777777655 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.6   5.7e+03      17      27 ..     147     157 ..     146     158 .. 0.73
   2 !   22.7   1.2   2.2e-08   7.9e-05       2      38 ..     221     259 ..     220     260 .. 0.90
   3 !   11.9   0.5   5.2e-05      0.19       4      33 ..     261     288 ..     259     289 .. 0.90
   4 ?   -2.9   7.1       2.3   8.3e+03      29      45 ..     355     370 ..     316     377 .. 0.49
   5 ?   -3.4   0.0       3.2   1.1e+04      40      47 ..     521     528 ..     518     530 .. 0.58

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.6
  Pentapeptide_3  17 FsgaasFsnad 27 
                     F+ +++F ++d
      EFC39241.1 147 FNEPVYFIDCD 157
                     77888888887 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 2.2e-08
  Pentapeptide_3   2 sganFsgaadFrgatFsgaa...sFsnadFgsadFsgarF 38 
                     +++nF+ + +F +++Fs+ a    F+ a+F+s++F+++++
      EFC39241.1 221 VDVNFKAS-YFKDCHFSNVAigsQFKKAQFESVTFEKCTI 259
                     5789****.***********8744**************96 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 5.2e-05
  Pentapeptide_3   4 anFsgaadFrgatFsgaasFsnadFgsadF 33 
                      +F+++ ++ ++  + +  F++++F+ a+F
      EFC39241.1 261 MHFKNN-NLKNCKCIEC-EFNGSVFEKANF 288
                     68****.***9999999.799999999999 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 2.3
  Pentapeptide_3  29 gsadFsgarFtgdvdFs 45 
                     ++  F +++F   ++F 
      EFC39241.1 355 STFIFINSTFA-HTSFA 370
                     33444444444.44444 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 3.2
  Pentapeptide_3  40 gdvdFsga 47 
                      d+++++a
      EFC39241.1 521 SDCNLNNA 528
                     36666655 PP

>> Pentapeptide  Pentapeptide repeats (8 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   0.1   7.3e-05      0.26      15      40 .]     212     237 ..     201     237 .. 0.69
   2 ?    1.1   0.0     0.089   3.2e+02      15      31 ..     241     257 ..     230     260 .. 0.63
   3 !   12.3   0.8   2.9e-05       0.1       7      28 ..     267     288 ..     263     290 .. 0.75
   4 ?    1.9   0.4     0.048   1.7e+02       3      33 ..     344     374 ..     344     376 .. 0.84
   5 ?    0.1   0.1      0.18   6.4e+02       5      11 ..     522     528 ..     519     532 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 7.3e-05
                   ECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide  15 ganlsgAnLtgAnlsgAdLsganLsg 40 
                   g +++g nL ++n+  + ++++ +s+
    EFC39241.1 212 GFDFRGMNLVDVNFKASYFKDCHFSN 237
                   66777777777777777777777765 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.089
                   ECCCESEEECT-B-TT- CS
  Pentapeptide  15 ganlsgAnLtgAnlsgA 31 
                   g+ ++ A + +++++++
    EFC39241.1 241 GSQFKKAQFESVTFEKC 257
                   55555555555555554 PP

  == domain 3  score: 12.3 bits;  conditional E-value: 2.9e-05
                   B-CCSCCEECCCESEEECT-B- CS
  Pentapeptide   7 nLsganLsganlsgAnLtgAnl 28 
                   nL +++  ++ ++g+++ +An+
    EFC39241.1 267 NLKNCKCIECEFNGSVFEKANF 288
                   6777777777777777777777 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.048
                   -TT-B-CCSCCEECCCESEEECT-B-TT-EE CS
  Pentapeptide   3 LsgAnLsganLsganlsgAnLtgAnlsgAdL 33 
                   +++ nL   +Ls   + ++++ ++++ + +L
    EFC39241.1 344 FENINLDAQDLSTFIFINSTFAHTSFAHVKL 374
                   6788899999999999999999999988887 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.18
                   T-B-CCS CS
  Pentapeptide   5 gAnLsga 11 
                   ++nL +a
    EFC39241.1 522 DCNLNNA 528
                   4555554 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.7   0.1   5.2e-08   0.00019       1      78 [.     103     185 ..     103     197 .. 0.80

  Alignments for each domain:
  == domain 1  score: 21.7 bits;  conditional E-value: 5.2e-08
                 EEEEETTEEEEEEHHHH...HTSTTSTTTSSGG.......GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-B---TTS-HHHHH CS
       BTB_2   1 vklnVgGtrfetskstL...srkpdtlLgkllkte...elddydeetneyffDRspklFetiLnyyrtggkLhrpeevelksll 78 
                 + lnVgGt++ +s  t    +r pd l++k+ ++e    + + + ++  yf+D +  +F++iL++++  g L r+ +v+l++ll
  EFC39241.1 103 IYLNVGGTIMTVSLGTFihnEREPDNLFKKMFTAEyplYQTSNQFNEPVYFIDCDLFIFKHILDWLKY-GILDREINVDLRKLL 185
                 579*************9444467**********9966523444444557*******************.999998888887775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (574 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1755  (0.0978861); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.49
# Mc/sec: 3536.29
//
Query:       EFC39242.1  [L=405]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.5e-06   26.6   0.5    2.4e-05   24.8   0.0    2.2  2  Pur_ac_phosph_N  Purple acid Phosphatase, N-terminal domain
  ------ inclusion threshold ------
      0.072   13.5   0.7        0.2   12.0   0.0    2.1  2  fn3              Fibronectin type III domain
        1.1    8.5   4.6        1.8    7.8   4.6    1.3  1  PfkB             pfkB family carbohydrate kinase


Domain annotation for each model (and alignments):
>> Pur_ac_phosph_N  Purple acid Phosphatase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   1.0      0.82   4.9e+03      28      47 ..     108     127 ..      49     167 .. 0.64
   2 !   24.8   0.0     4e-09   2.4e-05       4      94 .]     211     307 ..     208     307 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.82
  Pur_ac_phosph_N  28 ksvvrygtssdalestaeat 47 
                      +++ +++ ++++l++ ++ +
       EFC39242.1 108 NTNQEFELQNNNLNNIVTNS 127
                      33334444444444444443 PP

  == domain 2  score: 24.8 bits;  conditional E-value: 4e-09
  Pur_ac_phosph_N   4 vhlsltedtstsmtvsWitpektkksvvrygtssdalestaeatsstyet..tnyksgyshkatltgLepgttYyYrvgddeg.....gwSevy 90 
                      ++l l+e++++++++ ++t++ +  s++ + ++++++++t + + +  ++  t+ +s+y+h++ lt+L ++t Y ++vg  +        S   
       EFC39242.1 211 LTLLLNEKPQNEFIIKFFTQSRPILSFI-VINNTNMVNETINCNFQDLNEieTELVSRYVHTCILTNLNENTIYNFKVGMITIngsepIYSNLK 303
                      56778899999********999544444.445556777777777666666668899**********************8764433455777777 PP

  Pur_ac_phosph_N  91 sfkT 94 
                      +fkT
       EFC39242.1 304 QFKT 307
                      7776 PP

>> fn3  Fibronectin type III domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.2      0.87   5.2e+03      12      44 ..     125     154 ..     104     172 .. 0.62
   2 ?   12.0   0.0   3.3e-05       0.2      46      79 ..     260     293 ..     224     298 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.87
                 SSSEEEEEEE-CSSSSSTEEEEEEEEEETTSTS CS
         fn3  12 tstsltvsWeppkdgggpitgYeveyrekgsee 44 
                 t++ ++++ +     + p+ g ++++ + ++++
  EFC39242.1 125 TNSAISMTPTTV---STPVLGETIHLNNNNNNN 154
                 445555555555...677777777776666666 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 3.3e-05
                 EEEEEECSTSSEEEEESSSTTEEEEEEEEEEETS CS
         fn3  46 wneftvprtttsvtltgLkpgteYevrVqavngg 79 
                   +  v+r  +++ lt+L+++t Y+++V  ++ +
  EFC39242.1 260 IETELVSRYVHTCILTNLNENTIYNFKVGMITIN 293
                 44555888888*****************776655 PP

>> PfkB  pfkB family carbohydrate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   4.6    0.0003       1.8      61     197 ..      59     189 ..      53     205 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0003
                 SSHHHHHHHHHHHHTTEEETTEEEESSSEEEEEEEEETTTSEEEEEEEEGGGGGHHHHHHHHHHHHHGCTSEEEEESEECTTSHHHHHHHHHHHHHHTT CS
        PfkB  61 dDnfGeflleelkkegvdtdyvkidedtrtglalivvdedgertivfnrgaaadltkeeleededlleeadllyisgllsselpeavleelaeaakngg 159
                 +D+ + +  eel+++  d + + i ++   +l +i v+e+ + + ++n++++ ++++e   ++ +l + +++ +is   ++ +++ vl e++++ +n++
  EFC39242.1  59 NDKMSNSNQEELQQNEQDLNNLNIIDQ--SNLEIIQVNEEYNPNYNNNLNNNTNQEFEL--QNNNLNNIVTNSAIS-MTPTTVSTPVLGETIHLNNNNN 152
                 788889999999999999999999999..899999999854455555555555555532..233333333333333.589******************* PP

                 EEEEEECESSSHH.HHHHHHHHHCTESEEEEEHHHHHHH CS
        PfkB 160 tfdpnlldplgaq.fkeallellaladllkpneeEleal 197
                 +   n+ +      +k+ +l+ + + + +++ne E++  
  EFC39242.1 153 NNNTNMESEN--PlTKQLVLTSFFYGSCICLNEFEFSTT 189
                 6333333333..346788888888999999999999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1853  (0.103352); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2458.74
//
Query:       EFC39243.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      9e-34  117.1   0.0    5.3e-32  111.3   0.0    2.0  1  HSP33     Hsp33 protein
  ------ inclusion threshold ------
      0.042   13.9   0.3       0.11   12.6   0.2    1.7  2  CpXC      CpXC protein


Domain annotation for each model (and alignments):
>> HSP33  Hsp33 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.3   0.0   5.9e-36   5.3e-32       1     266 [.       8     317 ..       8     318 .. 0.76

  Alignments for each domain:
  == domain 1  score: 111.3 bits;  conditional E-value: 5.9e-36
                 .EEEEEEETTTTEEEEEEE-HHHHHHHHHHHT--H.......HHHHHHHHHHHHHHHHHCCS-.T-EEEEEEE.ESSTT-EEEEEEET........... CS
       HSP33   1 DkllrflledgsvRgrlvrltelveealkrhdlpp.......avtallgealaaaallastlkfegrltlqik.gdgplgllvaeads........... 80 
                 D++ +++++ g++R+ l+++++ +++ +++ +l+p        + +l+g+ ++a++ll+s lk+e+r++l++  ++  +  l  + ++           
  EFC39243.1   8 DYVKSYMSDCGKFRVSLIDSSDCLKTFINKFNLNPhssthdfKAINLMGQSMSASMLLSSLLKGEERIKLELFiSNSNIINLSNNTSNyssnnnnnnnn 106
                 89999*************************9877722222224568************************99978877777776655545666666665 PP

                 ....T..............SEEEEEES-TT---.HH-SCEEEEEEE..TC..EEEEEEE-SSSS.....SHHHHHHHHHHCC-S-EEEEEEEEEET..S CS
       HSP33  81 ....d..............gevRgyarnpavelpavgkGvlavtkd.qkegepyqGivelvsge.....iaedlehYfaqSEQiptavalavlvdk..r 153
                     +              ge+Rg+++ ++ + +   +  ++v+k  +++++p++++ +l+ ++     +++ +e++f++SEQipt+ +l ++++   +
  EFC39243.1 107 ninnNnnlinyvhvesiqvGEIRGFVKFDQGDDE--QNDIFSVSKIlMNHSKPVTSSLPLILDNsefsnLNNTFEEFFEKSEQIPTVTSLVCKQEFglD 203
                 5555055555555666666********6555555..5678888865447889********76666799*************************883332 PP

                 CEEEEEEEEEEESTTTSCCHHHHHHHHHCCS-.-HHH.HC.CC-HHHHHHHHHHSTS--EEEEEEE-EE-----HHHHHHHHHTT-CHHHHHHHHC..C CS
       HSP33 154 svkaagGlllQlLPgadeeliedleerlkalaatlteeelleelpaeellerlfheedvevleekpvefkCrCsrervekaLkslgkeeleeilee..d 250
                     + G+++Q+LP+++ +l e+l+   ++l++ +++    ++   ++l+++ + +e++e++  kp++f+CrCs++ + +aL +++ +el e+ +e  +
  EFC39243.1 204 --PISFGIIIQKLPSSE-DLSEELNYYKSKLNEMIKK-INNRQDVHDNLFYNFIINENLETVRYKPIDFYCRCSKDLILNALNTINVNELIEMRNEivN 298
                 ..5588********887.4555555444444433444.1112333377778888889*********************************999887543 PP

                 ...TEEEEE-TTT--EEEE CS
       HSP33 251 ...gkievtCefCgkkYrf 266
                     + e tC++C+++Y +
  EFC39243.1 299 gekIHFESTCDYCNNNYFI 317
                 32245799*********77 PP

>> CpXC  CpXC protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0      0.98   8.8e+03      93     112 ..     215     234 ..     196     239 .. 0.71
   2 ?   12.6   0.2   1.2e-05      0.11       3      46 ..     270     314 ..     268     324 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 0.98
        CpXC  93 idmaelaEkilileagldDr 112
                  + ++l E +  ++++l+++
  EFC39243.1 215 PSSEDLSEELNYYKSKLNEM 234
                 45566777777777777655 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 1.2e-05
        CpXC   3 CpaCgkefeaeiwtsidadedpelkeklldgs..lfeatCpkCgat 46 
                 C +C+k    ++ + i+++e  e+++++++g+   fe tC++C+++
  EFC39243.1 270 C-RCSKDLILNALNTINVNELIEMRNEIVNGEkiHFESTCDYCNNN 314
                 8.7****************************9545889*****976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1727  (0.0963244); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 1962.82
//
Query:       EFC39244.1  [L=463]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-83  279.9   3.6    2.6e-83  279.0   0.1    2.3  2  Nop       snoRNA binding domain, fibrillarin
    6.2e-20   71.4   2.8    1.8e-19   69.9   2.8    1.9  1  NOP5NT    NOP5NT (NUC127) domain


Domain annotation for each model (and alignments):
>> Nop  snoRNA binding domain, fibrillarin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.6     0.024   2.2e+02     162     209 ..      46      93 ..      33     106 .. 0.75
   2 !  279.0   0.1   2.9e-87   2.6e-83       1     229 [.     169     397 ..     169     398 .. 0.95

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.024
                 CHHT---SSSCHHHCSHHHHHTS-CCCHHHHHHHHHHHHHHHHHHHHT CS
         Nop 162 alkkkntpkyGliyhselvqkatppklkkkiaRllaaKvalaaRiDaf 209
                 + ++++  ++ l+  + +v++++++klkk + + la K +  a +D++
  EFC39244.1  46 SFENFKDTNEALVAATAIVESKLDKKLKKFLKKQLADKESKLAVCDKN 93 
                 2333467788999999****9999*****9******999988888854 PP

  == domain 2  score: 279.0 bits;  conditional E-value: 2.9e-87
                 HHHHHHHHHHHHHHHHHHHHTTTSTCHHHHS-SHHHHHHHHHHCCCCHCCT.HH..TT...HHHHHHHHHHHHCHHHH-SSS-S-HHHHHHHHHHHHHH CS
         Nop   1 lldeidkeintlhkrvrewYswhFpELeslvkdnleYakvvkligneredlekk..ee..deelakevimaakvtastsmgaelseedlknikelcdrv 95 
                 lld+idke+n++++rv+ewY+whFpEL+++++dn +Y+k+v +++ +r++++k   ++   e+lakev +aa v    smg+e+se+d+ +i++l+++v
  EFC39244.1 169 LLDDIDKELNIYVMRVKEWYGWHFPELSKVLRDNSAYIKTVLCLQ-NRNNAQKAplTDvlPEDLAKEVREAAIV----SMGTEISEDDMLHISKLAEEV 262
                 689******************************************.6788866643336655599999999999....********************* PP

                 HHHHHHHHHHHHHHHHHHHHHSHHHHHHCHHHHHHHHHHHHSSHHHHHCS-HHHHTTTT-HHHHCCCHH.T---SSSCHHHCSHHHHHTS-CCCHHHHH CS
         Nop  96 leleelrkelleYlesrmsaiAPNlsaLvGeevaarLishaGgLtnLakmPastiqilGaekalfralk.kkntpkyGliyhselvqkatppklkkkia 193
                  +++++r  l +Yl++rm+aiAPNl++L Ge v+arL++ aG+L+nLak+Past+qilGaeka+fralk ++ntpkyGl+yh++l+++a ppk+k+kia
  EFC39244.1 263 ESITTYRGALFDYLKNRMQAIAPNLTHLAGELVGARLMARAGSLMNLAKHPASTVQILGAEKAFFRALKsRHNTPKYGLLYHASLIGQA-PPKYKGKIA 360
                 *********************************************************************999***************77.********* PP

                 HHHHHHHHHHHHHHHTT---.-SHHHHHHHHHHHHHH CS
         Nop 194 RllaaKvalaaRiDafsekd.gslGkklreeiekklk 229
                 R+laaK+a+ aR+Da +ek+ +++G + re +ek+l+
  EFC39244.1 361 RVLAAKCAISARVDAMGEKEqATIGLDSREAVEKRLR 397
                 **************9998888**************97 PP

>> NOP5NT  NOP5NT (NUC127) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.9   2.8     2e-23   1.8e-19       1      64 [.       2      65 ..       2      66 .. 0.98

  Alignments for each domain:
  == domain 1  score: 69.9 bits;  conditional E-value: 2e-23
      NOP5NT  1 fiLfEtaaGYaLfkvkdkkllkkddlvkdsvsdlekfsklvkLkaFqkFesaaeALenanaise 64
                f+LfEtaaGYaLf+v d+ ++ ++++v++ +++ +k+sk +kLk+F+ F+++ eAL +a+ai+e
  EFC39244.1  2 FVLFETAAGYALFNVLDEGKITDVKSVDEMFANSSKLSKNIKLKSFENFKDTNEALVAATAIVE 65
                9*****************9999999*************************************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (463 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1400  (0.0780858); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.30s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2665.91
//
Query:       EFC39245.1  [L=367]
Description: DRG GTPase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.3e-41  138.9   0.1    1.2e-40  137.8   0.1    1.6  1  MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
    4.2e-21   75.1   0.0    9.3e-21   74.0   0.0    1.6  1  MMR_HSR1      50S ribosome-binding GTPase
    3.6e-20   71.7   0.1    6.2e-20   71.0   0.1    1.4  1  TGS           TGS domain
    2.7e-10   40.0   0.1    6.7e-10   38.7   0.0    1.7  2  FeoB_N        Ferrous iron transport protein B
    0.00018   21.6   0.1       0.18   11.8   0.0    2.5  2  Dynamin_N     Dynamin family
     0.0016   17.4   0.0     0.0035   16.4   0.0    1.5  1  MeaB          Methylmalonyl Co-A mutase-associated GTPase Mea
  ------ inclusion threshold ------
      0.021   14.4   0.2         13    5.3   0.0    3.8  3  GTP_EFTU      Elongation factor Tu GTP binding domain
      0.049   13.1   0.2        1.4    8.3   0.0    2.6  3  KTI12         Chromatin associated protein KTI12
      0.052   12.7   0.0      0.088   12.0   0.0    1.4  1  NB-ARC        NB-ARC domain
       0.06   12.7   0.0        0.1   11.9   0.0    1.3  1  AIG1          AIG1 family


Domain annotation for each model (and alignments):
>> MMR_HSR1_Xtn  C-terminal region of MMR_HSR1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  137.8   0.1   6.4e-44   1.2e-40       1     106 []     185     290 ..     185     290 .. 0.99

  Alignments for each domain:
  == domain 1  score: 137.8 bits;  conditional E-value: 6.4e-44
  MMR_HSR1_Xtn   1 kgGikitstvkltkldeetvkkilkeykihnaevliredvtvDdlidviegnrvYipclyvlNKiDlisleeldelarepnsvviSaekelnldeLk 97 
                   kgG+++ s+v+lt+l++e vk+il+eyk+ na++++r+d+tvD+lidviegnr Yip++y++NKiD+i++eeld ++r pn+++iSa++e+n+d L+
    EFC39245.1 185 KGGLNMMSSVPLTHLTNEIVKAILQEYKCPNADIMFRCDATVDELIDVIEGNRAYIPAIYAMNKIDQITIEELDLIDRIPNACPISAHHEWNMDGLL 281
                   69*********************************************************************************************** PP

  MMR_HSR1_Xtn  98 ekiweeLnL 106
                   ek+we+L+L
    EFC39245.1 282 EKVWEYLDL 290
                   *******97 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.0   0.0   5.2e-24   9.3e-21       1      97 [.      65     164 ..      65     182 .. 0.83

  Alignments for each domain:
  == domain 1  score: 74.0 bits;  conditional E-value: 5.2e-24
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT....TTCSHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas....eeklkpld 94 
                 ++++vG p vGKStL+n++t++ ++v+++ +tT++ + g +++kg +++l+D+pG+iega+++kg g+++ +  + ++lil+v+da     +   k+++
  EFC39245.1  65 RIGLVGFPSVGKSTLLNKMTNTFSEVASYEFTTLTCIPGVINYKGARLQLLDLPGIIEGAKDGKGRGRQVISTARtCNLILIVLDALkpltH--KKKIE 161
                 699******************************************************************99988878********7644321..22333 PP

                 HHH CS
    MMR_HSR1  95 eel 97 
                  el
  EFC39245.1 162 YEL 164
                 444 PP

>> TGS  TGS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.0   0.1   3.5e-23   6.2e-20       1      60 []     291     365 ..     291     365 .. 0.97

  Alignments for each domain:
  == domain 1  score: 71.0 bits;  conditional E-value: 3.5e-23
                 EEEEE.TTSSEEE......EETTB-.HHHHHHHHSTTHHHHEEEEEECS.......EEEETTSBB-SSEEEEEEE CS
         TGS   1 irvyt.PdGkvpd......lprgat.veDfAykIhrslakkfiyAlVnG.......qrvgldhvLedgdvveIvt 60 
                 irvyt P+G+v d      ++r ++  eDf+ +Ih+ + ++f+yA V+G       q+vg dh+L d+d+v+Iv+
  EFC39245.1 291 IRVYTkPKGQVADfgapviIRRDKSsMEDFCTRIHKHILRQFKYAWVWGqsvkhqpQKVGKDHQLLDEDIVQIVK 365
                 89*****************8887777***********************************************97 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.7   0.0   3.8e-13   6.7e-10       2      88 ..      65     150 ..      64     160 .. 0.80
   2 ?   -2.8   0.0       2.2     4e+03     106     121 ..     240     255 ..     232     261 .. 0.75

  Alignments for each domain:
  == domain 1  score: 38.7 bits;  conditional E-value: 3.8e-13
                 EEEEEESTTSSHHHHHHHHHTTSEEEEESTTSSSEEEEEEEEETTEEEEEEE----SSSSSSSHHHHHHHHHHH.CTSSSEEEEEEEG CS
      FeoB_N   2 tvalvGnpnvGkttlfnaltgakqkvgNwpGvtvekkegklklkgkeveivDlPGiYslsayseeekvardfll.eeepdvvvnvvda 88 
                 ++ lvG p vGk+tl+n++t++ ++v+ +  +t     g +++kg +++++DlPGi +       +   r+++   ++ ++++ v+da
  EFC39245.1  65 RIGLVGFPSVGKSTLLNKMTNTFSEVASYEFTTLTCIPGVINYKGARLQLLDLPGIIE--GAKDGKGRGRQVIStARTCNLILIVLDA 150
                 588****************************************************954..3333344455555523345666666666 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.2
                 SSEEEEEETHHHHHHT CS
      FeoB_N 106 vpvvlalnmideaekk 121
                 +p + a+n+id+++ +
  EFC39245.1 240 IPAIYAMNKIDQITIE 255
                 5778888888887655 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.1    0.0025       4.4       1      19 [.      66      84 ..      66     108 .. 0.85
   2 !   11.8   0.0    0.0001      0.18     101     147 ..     110     159 ..     103     166 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0025
                EEEEEBTTTTHHHHHHHHH CS
   Dynamin_N  1 iavvGsqSsGKSSvlnaLl 19
                i +vG  S GKS++ln+++
  EFC39245.1 66 IGLVGFPSVGKSTLLNKMT 84
                7899************986 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 0.0001
                 -SEEEEE---B-SSSGTTS...HHHHHHHSTTEEEEEEEETTS-CCC-CH CS
   Dynamin_N 101 kgltlvDlPGldsvnkrdq...elvkeyikkadiilavtsanhdlsnsea 147
                  +l l+DlPG+++ +k  +   + v ++++ +++il v++a + l+++++
  EFC39245.1 110 ARLQLLDLPGIIEGAKDGKgrgRQVISTARTCNLILIVLDALKPLTHKKK 159
                 5799**********999999999999999************999997654 PP

>> MeaB  Methylmalonyl Co-A mutase-associated GTPase MeaB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   1.9e-06    0.0035      26      55 ..      61      89 ..      57     103 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.9e-06
                -S-SEEEEEEE-TTSSHHHHHHHHHHHHHC CS
        MeaB 26 aGraqvvGltGvPGaGkstlvealglelrr 55
                +G a ++Gl G+P +Gkstl+++++ ++ +
  EFC39245.1 61 SGDA-RIGLVGFPSVGKSTLLNKMTNTFSE 89
                5554.8******************998875 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0     0.096   1.7e+02       6      29 ..      66      89 ..      64      96 .. 0.79
   2 ?   -0.1   0.0      0.31   5.5e+02      85     103 ..     132     150 ..      88     159 .. 0.63
   3 ?    5.3   0.0     0.007        13     123     142 ..     240     260 ..     222     289 .. 0.58

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.096
                EEEEESTTSSHHHHHHHHHHHTTS CS
    GTP_EFTU  6 igiighvDhGKtTLtdrLlyktga 29
                ig++g    GK+TL+ +++ + ++
  EFC39245.1 66 IGLVGFPSVGKSTLLNKMTNTFSE 89
                677777889*******99976655 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.31
                 HHHHHHHHT-SEEEEEEET CS
    GTP_EFTU  85 kevirglrvlDgavlvvda 103
                 ++vi ++r++++ ++v+da
  EFC39245.1 132 RQVISTARTCNLILIVLDA 150
                 4678888888888888887 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.007
                 TEEEEEEESCGST.HHHHHHH CS
    GTP_EFTU 123 vpiivfiNKmDrl.kaelkei 142
                 +p i ++NK+D++ ++el+ i
  EFC39245.1 240 IPAIYAMNKIDQItIEELDLI 260
                 456666666666644444433 PP

>> KTI12  Chromatin associated protein KTI12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.0   0.00078       1.4       6      27 ..      68      89 ..      65     108 .. 0.86
   2 ?    1.9   0.0     0.068   1.2e+02     171     220 ..     170     221 ..     135     258 .. 0.74
   3 ?   -3.0   0.0       2.1   3.8e+03     179     206 ..     340     367 .]     308     367 .] 0.76

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00078
                EE--TTSSHHHHHHHHHHHHHH CS
       KTI12  6 ltGlPssGKstrakeLakalee 27
                l G+Ps+GKst+ +++ ++++e
  EFC39245.1 68 LVGFPSVGKSTLLNKMTNTFSE 89
                78*****************998 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.068
                 HHHTS--SSSTT-------HHHHH..HHHHHHHHHHHHHH....HTT--HHH CS
       KTI12 171 ekkklkpnqatlskplaeanflqe..Ldketseivkeileaqksavaidklt 220
                   +k++pn    +k +   n++    L++ t+eivk+il++ k  +a  +++
  EFC39245.1 170 RLNKQPPNITFKKKEKGGLNMMSSvpLTHLTNEIVKAILQEYKCPNADIMFR 221
                 4556677777777777766766543389999999999999877666555555 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 2.1
                 SSTT-------HHHHHHHHHHHHHHHHH CS
       KTI12 179 qatlskplaeanflqeLdketseivkei 206
                 q++ ++p++ ++  q Ld+ + +ivk+i
  EFC39245.1 340 QSVKHQPQKVGKDHQLLDEDIVQIVKKI 367
                 6777788888888888888888888876 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   4.9e-05     0.088      22      55 ..      65      99 ..      57     178 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 4.9e-05
                EEEEEESTTSSHHHHHHHHCCSHCCCCC.CBTEEE CS
      NB-ARC 22 vvalvGmgGvGKttlakqilnksdeveg.rFdsva 55
                 ++lvG + vGK+tl++++ n ++ev + +F  + 
  EFC39245.1 65 RIGLVGFPSVGKSTLLNKMTNTFSEVASyEFTTLT 99
                599***********************987777655 PP

>> AIG1  AIG1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   5.7e-05       0.1       2      93 ..      65     150 ..      64     165 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 5.7e-05
                 EEEEESSTTSSHHHHHHHHHTS--SS--TTTS---SS-EEEEEEETTEEEEEEE--SCCCTTCCHHCHHHHHHHHHHHCTT-ESEEEEEEET CS
        AIG1   2 tivlvGktgnGkSaTgNsilgkkaFesklsaqsvtkkcqkksrtwdgkkinViDTPglfdlsvsadkiskeivrclllseegihalllvlsl 93 
                 +i lvG   +GkS+  N +  ++ F+  +s +  t +c   +   +g +++  D Pg+++  ++ +   ++++     ++   + +l+vl++
  EFC39245.1  65 RIGLVGFPSVGKSTLLNKM--TNTFSEVASYEFTTLTCIPGVINYKGARLQLLDLPGIIEGAKDGKGRGRQVIS----TARTCNLILIVLDA 150
                 6779*************97..789*99999*******************************9998888887775....34446667777664 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (367 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       576  (0.0321267); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2060.93
//
Query:       EFC39246.1  [L=217]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.12   12.8   4.9       0.15   12.5   3.5    1.8  2  BRCT_2    BRCT domain, a BRCA1 C-terminus domain


Domain annotation for each model (and alignments):
>> BRCT_2  BRCT domain, a BRCA1 C-terminus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0     0.078   1.4e+03      54      74 ..      95     118 ..      69     121 .. 0.70
   2 ?   12.5   3.5   8.2e-06      0.15      12      75 ..     113     194 ..     110     197 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.078
      BRCT_2  54 e...laekrkrrvvspkyIkdCik 74 
                 e   +++k k+++   k+I+ C +
  EFC39246.1  95 EikvQKQKIKQQSKEEKFIQMCKS 118
                 245677888888888888888866 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 8.2e-06
      BRCT_2  12 in..daepspsreklkklIeknGG..evvetitsavyiviaesneee................laekrkrrvvspkyIkdCikk 75 
                 i   +++ +++++k+ k+Ie nGG  e++ ++ +   iv +++++++                + ek kr+ ++ +y++ C +k
  EFC39246.1 113 IQmcKSRSEHKKKKIIKKIERNGGlnELSTNQIN--SIVHSNTTNNNteiisesdetdsetelHLEKLKREKLKKQYLYKCSAK 194
                 5554555669**************7766666633..333333333334566666666789999888999999999999999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2814  (0.156952); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.55
# Mc/sec: 1197.08
//
Query:       EFC39247.1  [L=228]
Description: PX domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.3e-14   51.9   2.4    6.3e-14   51.9   2.4    1.5  2  PX          PX domain
  ------ inclusion threshold ------
      0.015   14.4   1.2      0.035   13.2   0.5    1.7  2  Plant_NMP1  Plant nuclear matrix protein 1 (NMP1)


Domain annotation for each model (and alignments):
>> PX  PX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.9   2.4     7e-18   6.3e-14      14     112 ..      68     174 ..      53     175 .. 0.84
   2 ?   -3.0   0.1      0.79   7.1e+03      44      53 ..     193     202 ..     181     223 .. 0.55

  Alignments for each domain:
  == domain 1  score: 51.9 bits;  conditional E-value: 7e-18
                 E...TTSSEEEEEEEEEETTSSSEEEEEEEHHHHHHHHHHHHHHHT.....TSTSTSSSTSGSSSSSCTTSHHHHHHHHHHHHHHHHHHHTSCHHHHSH CS
          PX  14 s...gskkhsyylyevelktgakewtvkRrYsdFeeLhskLlrkfp.....rvkiPplPkkvlfgsvrkkdeefiekrrkgLeeyLqrllnhpelrnse 104
                 +   ++ + ++y ++ ++++ ++++ v Rr+s+F++L ++L +k+      + ++ ++ +k+++   +k+ +e+i+ r ++L++ L  +++h+ +rn+e
  EFC39247.1  68 QsliHDNRFTVYEIKATNENDSQTHYVFRRFSEFVKLVNHLAEKYAdkasdCEQLHSFLPKQPWFWTNKFAKEVIDDRTEKLTNLLDFISSHEIFRNDE 166
                 243445555555555555555*****************************988899988888887669******************************* PP

                 HHHHHHHS CS
          PX 105 vlteFLev 112
                    eFL+ 
  EFC39247.1 167 QYFEFLQC 174
                 ******96 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.79
                 HHHHHHHHHH CS
          PX  44 FeeLhskLlr 53 
                 F++ +++L++
  EFC39247.1 193 FQQSRKDLKN 202
                 3333333333 PP

>> Plant_NMP1  Plant nuclear matrix protein 1 (NMP1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1     0.033   2.9e+02     114     144 ..      87     117 ..      53     170 .. 0.60
   2 ?   13.2   0.5   3.9e-06     0.035     132     203 ..     142     214 ..     122     225 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.033
  Plant_NMP1 114 adnpewsvdeqvakdiqlldaiaekqaqifs 144
                  d     v  + +  ++l++ +aek a+  s
  EFC39247.1  87 NDSQTHYVFRRFSEFVKLVNHLAEKYADKAS 117
                 4444444444444455555555555554433 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.9e-06
  Plant_NMP1 132 ldaiaekqaqi..fseecklfpadvqiqsiyplpdiaelekklseyskklsslqqvvdelaskkdynpdeeyae 203
                 +d  +ek +++  f     +f  d q    +   d+  lek ls y ++l ++qq  ++l  k +y+  +e + 
  EFC39247.1 142 IDDRTEKLTNLldFISSHEIFRNDEQYF-EFLQCDMKMLEKALSYYRNRLYHFQQSRKDLKNKDEYERSQEMVR 214
                 6666677666533455667888888865.46778********************************99888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1168  (0.0651459); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1331.12
//
Query:       EFC39248.1  [L=608]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.5e-38  128.1  12.4      5e-07   30.3   0.1    7.8  7  WD40             WD domain, G-beta repeat
    1.1e-26   93.5   0.0    2.1e-26   92.6   0.0    1.4  1  adh_short        short chain dehydrogenase
    1.8e-18   66.6   3.1     0.0016   18.7   0.0    6.0  6  ANAPC4_WD40      Anaphase-promoting complex subunit 4 WD40 do
      5e-18   65.5   0.1    1.4e-17   64.1   0.0    1.7  2  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
    1.3e-06   28.5   0.0    2.5e-06   27.6   0.0    1.4  1  KR               KR domain
    4.1e-05   22.5   6.2      0.024   13.4   0.4    3.5  3  Nucleoporin_N    Nup133 N terminal like
     0.0001   21.0   0.1       0.32    9.5   0.0    3.1  3  Cytochrom_D1     Cytochrome D1 heme domain
     0.0009   18.8   0.1        2.9    7.4   0.0    3.5  3  HPS3_N           Hermansky-Pudlak syndrome 3
     0.0013   18.0   0.0     0.0028   16.8   0.0    1.7  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
     0.0048   15.9   4.2          3    6.7   0.2    4.0  4  Ge1_WD40         WD40 region of Ge1, enhancer of mRNA-decappi
     0.0098   15.2  13.2      0.071   12.4   0.6    4.0  4  WD40_like        WD40-like domain
  ------ inclusion threshold ------
      0.055   11.8   3.0       0.67    8.2   0.1    3.0  3  Frtz             WD repeat-containing and planar cell polarit
      0.096   12.4   0.2        3.2    7.4   0.1    2.8  3  Hira             TUP1-like enhancer of split
       0.13   12.7   1.3         18    5.9   0.0    2.6  2  DUF1829          Domain of unknown function DUF1829
          5    6.6   8.1       0.99    8.8   1.0    2.8  3  Clathrin-link    Clathrin, heavy-chain linker


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.1   0.00089       1.1      13      37 ..     328     347 ..     312     348 .. 0.76
   2 !   20.5   0.0   5.3e-07   0.00063       5      38 .]     356     390 ..     352     390 .. 0.88
   3 !    7.1   0.0    0.0089        11      15      38 .]     409     432 ..     405     432 .. 0.93
   4 !   18.1   0.0   3.1e-06    0.0036       5      38 .]     440     475 ..     436     475 .. 0.83
   5 !   24.8   0.1   2.3e-08   2.7e-05       2      38 .]     480     517 ..     479     517 .. 0.93
   6 !   30.3   0.1   4.2e-10     5e-07       2      37 ..     522     558 ..     521     559 .. 0.94
   7 !   18.4   0.1   2.4e-06    0.0029       2      35 ..     564     598 ..     563     600 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00089
                 EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40  13 vtslafspdgawlasGsdDgtvriW 37 
                 vt+      ++ +++Gs D ++++W
  EFC39248.1 328 VTCA-----QDKIITGSVDSSIKVW 347
                 7666.....577889********** PP

  == domain 2  score: 20.5 bits;  conditional E-value: 5.3e-07
                 EEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                  tl+GH  ++ s+  ++ g+++a++s+D  +r+Wd
  EFC39248.1 356 LTLEGHrLGIISIVSDQTGKYVATSSMDSVIRVWD 390
                 5899**86666999999*****************9 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0089
                 EEEEETTSSEEEEEETTSEEEEEE CS
        WD40  15 slafspdgawlasGsdDgtvriWd 38 
                  lafs d + la+G++ g+v i++
  EFC39248.1 409 TLAFSADAQHLATGTRSGNVNIFN 432
                 699*****************9987 PP

  == domain 4  score: 18.1 bits;  conditional E-value: 3.1e-06
                 EEEESS..SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   5 rtltGH..ssvtslafspdgawlasGsdDgtvriWd 38 
                 ++l+++  +++ s+a+s  g++la+G+ Dg+v ++d
  EFC39248.1 440 QSLDTQkkTFIMSVAYSNCGKYLACGGQDGSVCVFD 475
                 56667753349***********************98 PP

  == domain 5  score: 24.8 bits;  conditional E-value: 2.3e-08
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +++++l+GH  sv+s+ f  d++ l+s+sdD+++ ++d
  EFC39248.1 480 KLMHHLEGHsMSVRSIVFTNDSQRLISASDDKHINVYD 517
                 689******666************************98 PP

  == domain 6  score: 30.3 bits;  conditional E-value: 4.2e-10
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 +++++l+GH s+v  la sp g+ +asGs D+ v+iW
  EFC39248.1 522 SLVKSLSGHhSFVLTLAASPTGQIFASGSADRQVKIW 558
                 7899*****999************************* PP

  == domain 7  score: 18.4 bits;  conditional E-value: 2.4e-06
                 EEEEEEESSSS.EEEEEEETTSSEEEEEETTSEEE CS
        WD40   2 qclrtltGHss.vtslafspdgawlasGsdDgtvr 35 
                 +c+++++ H++ v++l+f+ +g+ l+s sdD ++ 
  EFC39248.1 564 ECIHSFEEHKDqVWGLSFNTSGDSLISVSDDMSIV 598
                 7********555**************99*999985 PP

>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.6   0.0   1.8e-29   2.1e-26       3     187 ..      45     244 ..      43     251 .. 0.85

  Alignments for each domain:
  == domain 1  score: 92.6 bits;  conditional E-value: 1.8e-29
                 EEEESTTSHHHHHHHHHHH.HTT-EEEE.EESCHHHHHHHHHHHHHT.........TSEEEEEE-TTTSHHHHHHH.HHHHHHHHSSESEEEE---S.S CS
   adh_short   3 vlvtGassGIGraiakela.keGakvvv.vdrseekleevakelkee.........gakalaiqvDvtdreeveal.vekavkklgkldvLvnNAGi.t 88 
                 +++tG+++GIG a+ kel+ +   + +v ++ se+ + + ++++ +e         +++++a+ +D+++++++ ++ +  ++++l ++d+ +nNAG+  
  EFC39248.1  45 IVITGGTRGIGFALIKELLiNYPNHKIVyTGTSENSITKSKEQFVKEipnfdsnwyNTRLFACVCDISNYNDIHQVlIPFIKNNLNQVDLWINNAGVgD 143
                 89*************99862555555554888888876665555444443366677788**********9999886267899999************99 PP

                 --SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEEEGGG..TSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSH CS
   adh_short  89 gsgpfselseeewervievNltgvflltravlpamlkqssGrIvnvsSvag..kvpvagvaaYsAsKaavagltrslakelaptgirvnavaPGlvdTd 185
                  +++ +++s++e++ +++vN +g++ +t+a+++ +++q++G  v      g     +++++ Y+ sKa  +++++sl  e a++++ v+ v PG+v T 
  EFC39248.1 144 CRKKLKDMSQSEIDGILNVNTHGTVYATQAAIQLLDSQKEGGHVYLMEGLGsdGRTSPELSIYGMSKASYRQFVSSLVGETADSKVGVHRVSPGMVITS 242
                 999*********************************88777777777777734566899***************************************9 PP

                 HH CS
   adh_short 186 ma 187
                 m 
  EFC39248.1 243 ML 244
                 96 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0         3   3.6e+03      14      41 ..     224     253 ..     220     257 .. 0.67
   2 !    6.7   0.1    0.0074       8.8      12      73 ..     337     397 ..     329     407 .. 0.83
   3 !   13.3   0.0   6.7e-05      0.08      43      89 ..     409     455 ..     400     456 .. 0.91
   4 !   18.7   0.0   1.4e-06    0.0016      36      80 ..     445     489 ..     442     492 .. 0.90
   5 !   14.0   0.0   3.9e-05     0.047      37      81 ..     488     532 ..     486     538 .. 0.89
   6 !   14.6   0.0   2.5e-05     0.029      39      89 ..     532     581 ..     528     584 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3
  ANAPC4_WD40  14 tedgellvfRlngqrvwtl..eedkedsev 41 
                  t+d+++ v+R++  +v t    +d+ +s+v
   EFC39248.1 224 TADSKVGVHRVSPGMVITSmlCTDTMNSKV 253
                  678888888888877777655445555555 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0074
  ANAPC4_WD40  12 latedgellvfRl.ngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvv 73 
                   ++ d+++ v Rl n++   tl  +++   + s+   + gk  a +  d+ +r+ d+e+gk  
   EFC39248.1 337 TGSVDSSIKVWRLdNFELALTL--EGHRLGIISIVSDQTGKYVATSSMDSVIRVWDIEKGKST 397
                  5677889999999556666666..899999999999************************965 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 6.7e-05
  ANAPC4_WD40  43 sLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                   La++ d + La ++  g+v+++++++g+  +sl++++++ ++++ +
   EFC39248.1 409 TLAFSADAQHLATGTRSGNVNIFNVQTGEKEQSLDTQKKTFIMSVAY 455
                  699**********************************9988887765 PP

  == domain 4  score: 18.7 bits;  conditional E-value: 1.4e-06
  ANAPC4_WD40  36 kedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvks 80 
                  +++  + s+a+++ gk La + +dg+v ++d+++ k++h+l+ +s
   EFC39248.1 445 QKKTFIMSVAYSNCGKYLACGGQDGSVCVFDISTSKLMHHLEGHS 489
                  5677799*********************************98776 PP

  == domain 5  score: 14.0 bits;  conditional E-value: 3.9e-05
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                  ++ +vrs+ + +d + L  a +d +++++d++sg +v+sls +++
   EFC39248.1 488 HSMSVRSIVFTNDSQRLISASDDKHINVYDINSGSLVKSLSGHHS 532
                  5678**********************************9987765 PP

  == domain 6  score: 14.6 bits;  conditional E-value: 2.5e-05
  ANAPC4_WD40  39 sevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgW 89 
                  s v  La +p g+++a + +d +v++ + ++ +++hs++ ++++ v  l++
   EFC39248.1 532 SFVLTLAASPTGQIFASGSADRQVKIWETSTLECIHSFEEHKDQ-VWGLSF 581
                  567889999******************************99995.777666 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.1   0.0   1.2e-20   1.4e-17      18     185 ..      68     250 ..      49     289 .. 0.76
   2 ?   -2.4   0.0       2.4   2.8e+03      63     108 ..     481     525 ..     478     540 .. 0.84

  Alignments for each domain:
  == domain 1  score: 64.1 bits;  conditional E-value: 1.2e-20
                   T-EEEEEESSGGH.HHHHHHHHHHTT...SE.E......EE--TTSHHHHHHH.HHHHHHHHSSEEEEEE-----EGCSS-GGGH-HHHHHHHHHHH CS
  adh_short_C2  18 Gaevvltdlneea.kkrveelaeelg...ae.v......lecDVtdeeqveal.veevvekfgklDilvnnagiapklkgpfletsreefdraldvn 102
                     ++v+t  +e++  k+ e++++e++   ++ +      + cD+++ ++++++ +  ++++++++D  +nnag+ +  ++++ ++s++e+d +l+vn
    EFC39248.1  68 NHKIVYTGTSENSiTKSKEQFVKEIPnfdSNwYntrlfaCVCDISNYNDIHQVlIPFIKNNLNQVDLWINNAGVGDC-RKKLKDMSQSEIDGILNVN 163
                   55566666666666566666666555443222122334699*********885267889999**************8.******************* PP

                   THHHHHHHHHHHHHCTSC...CEEEEEEEGGGT.SBSTTTTHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTGGGGSTTH CS
  adh_short_C2 103 lyslfllakaalplmkeg...gsivnlssvgae.rvvpnynaygaaKaalealtrylAvelgpkgiRvNavspgpikTlaasgikgf 185
                   ++++++ ++aa++l+ ++   g +  +  +g+  r+ p+ ++yg++Ka+  +++ +l  e ++ ++ v+ vspg++ T +    + +
    EFC39248.1 164 THGTVYATQAAIQLLDSQkegGHVYLMEGLGSDgRTSPELSIYGMSKASYRQFVSSLVGETADSKVGVHRVSPGMVITSMLCTDTMN 250
                   *************8765556599999988877636799999*************************************995443333 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.4
                   HHHHHSSEEEEEE-----EGCSS-GGGH-HHHHHHHHHHHTHHHHH CS
  adh_short_C2  63 vvekfgklDilvnnagiapklkgpfletsreefdraldvnlyslfl 108
                   +++++++  + v ++ ++++ +++++++s+++  ++ d+n  sl++
    EFC39248.1 481 LMHHLEGHSMSVRSIVFTND-SQRLISASDDKHINVYDINSGSLVK 525
                   56666777778899999999.9999999999999999999999876 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   0.0   2.1e-09   2.5e-06       4     120 ..      46     171 ..      44     179 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 2.1e-09
                 EEETTTSHHHHHHHHHHHHHH.S-EEEEE-SS...--HHHHHHHHHHHHTT-.....EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE------. CS
          KR   4 litGGlGgLGlelarwlaekg.arhlvllsRsa.aadedskaliaelealga.....evevvaaDvsdkdavealleeikaee.ppikGvihaAgvlr. 93 
                 +itGG+ g+G +l++ l+ +  ++++v+++ s+ + +++++++++e+ + +      +  ++ +D+s+ ++++++l  + +++ +++   i+ Agv + 
  EFC39248.1  46 VITGGTRGIGFALIKELLINYpNHKIVYTGTSEnSITKSKEQFVKEIPNFDSnwyntRLFACVCDISNYNDIHQVLIPFIKNNlNQVDLWINNAGVGDc 144
                 8************999875554*********97444555556666665543333333999999**********99777666666*************97 PP

                 ---TTT--HHHHHHHHTTTTHHHHHHH CS
          KR  94 dklleemtaedleqvlapKvkGawnLh 120
                  k+l++m++++++ +l+   +G+    
  EFC39248.1 145 RKKLKDMSQSEIDGILNVNTHGTVYAT 171
                 899***********9999999987655 PP

>> Nucleoporin_N  Nup133 N terminal like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.11   1.4e+02     283     356 ..     174     244 ..     164     264 .. 0.85
   2 !   13.4   0.4     2e-05     0.024     199     240 ..     360     399 ..     318     442 .. 0.79
   3 !    8.5   0.4   0.00061      0.73     201     276 ..     489     563 ..     456     572 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.11
                    CEEEEEEECSSSEEEEEEEEEEEECTTT-EEEEEEEEEEEEECCCCCSSSSSSSBECC-CCSSETTCEEEEEEE CS
  Nucleoporin_N 283 llhlvaitsngvrlylllsssssdspsalslvsvrfppkrlntysskllenkkksklllpskiispgiflfvvf 356
                     ++l+  + +g + yl+   + sd++++  l+    +  + +++ s+l+ +++ sk+ + +  +spg+++ ++ 
     EFC39248.1 174 AIQLLDSQKEGGHVYLMEGLG-SDGRTSPELSIYGMSKASYRQFVSSLVGETADSKVGVHR--VSPGMVITSML 244
                    678888888888888888888.99999999999999999999999**99999*********..******99886 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 2e-05
                    --GG-EEEEEEECCTCEEEEEETTSEEEEEEEETTCEE-EEE CS
  Nucleoporin_N 199 sereeivqlridssrrilytlsskgvirvydlsasngesslk 240
                      r  i+++++d++ + + t s ++virv+d++ + g+s++ 
     EFC39248.1 360 GHRLGIISIVSDQTGKYVATSSMDSVIRVWDIE-K-GKSTII 399
                    56778****************************.4.445544 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00061
                    GG-EEEEEEECCTCEEEEEETTSEEEEEEEETTCEE-EEEEEEEHHHHHHHH.HHSCHTTTCGCTTT-EEEEEEES CS
  Nucleoporin_N 201 reeivqlridssrrilytlsskgvirvydlsasngesslksdidirqilleaitesliasaplaskslkildispv 276
                    + ++ +++  + +++l+++s ++ i+vyd+++ +  +sl+++ ++   l+  ++++ i ++ +a+ ++ki+  s +
     EFC39248.1 489 SMSVRSIVFTNDSQRLISASDDKHINVYDINSGSLVKSLSGHHSFVLTLAA-SPTGQIFASGSADRQVKIWETSTL 563
                    5567888888899******************33335555555555444443.577777777888999999877765 PP

>> Cytochrom_D1  Cytochrome D1 heme domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   0.0    0.0028       3.4      14     119 ..     341     446 ..     334     454 .. 0.82
   2 !    9.5   0.0   0.00027      0.32     291     365 ..     467     547 ..     449     550 .. 0.86
   3 ?    1.5   0.0     0.072        86     292     337 ..     552     595 ..     545     602 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0028
                   GTEEEEEETTT-SEEEEEE-STTEEEEEE-TT.SSEEEEEETTSEEEEEESSSSSEEEEEE-.SSEEEEEEE--TTSEEEEEEEETTEEEEEETTT- CS
  Cytochrom_D1  14 agkvalldgdskeilavletgyalHisrvfasdgRyvyvigRDgkvtliDLwakeivaevki.GlnarsvavSqddryvivgnYlPgqlvildaetL 109
                   + ++++   d++e   +le++    is v+ + g+yv + + D+ + + D+ + +    +++  l++  +a S d +++++g+   g++ i++ +t 
    EFC39248.1 341 DSSIKVWRLDNFELALTLEGHRLGIISIVSDQTGKYVATSSMDSVIRVWDIEKGKSTIIIEApPLESWTLAFSADAQHLATGT-RSGNVNIFNVQTG 436
                   55666666677777777777766689*************************99996666655269**************9999.579******9999 PP

                   -EEEEEE--E CS
  Cytochrom_D1 110 elvkvisarg 119
                   e  + + +++
    EFC39248.1 437 EKEQSLDTQK 446
                   9888877765 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00027
                   SHT-EEEEETTBT-EEE-HHHHHT--EEEEEE-TTSSEEEEEEE--SSEEEEEETTTTEEEEEEE.........--SEEEEEEH CS
  Cytochrom_D1 291 dndsvaviDkktlekvltlaesaglkvvhvEfnkdGdevwlSvwdgkdalvvyDdktlklkkvik.........lvtPsGkfnv 365
                   +++sv v+D  t + +++l+ ++  +v  + f++d +  ++S  d k  + vyD ++  l+k++          + +P+G+ ++
    EFC39248.1 467 QDGSVCVFDISTSKLMHHLEGHSM-SVRSIVFTNDSQ-RLISASDDK-HINVYDINSGSLVKSLSghhsfvltlAASPTGQIFA 547
                   5789***************98876.899999**9965.589999999.9*************9999999998888899998765 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.072
                   HT-EEEEETTBT-EEE-HHHHHT--EEEEEE-TTSSEEEEEEE--S CS
  Cytochrom_D1 292 ndsvaviDkktlekvltlaesaglkvvhvEfnkdGdevwlSvwdgk 337
                   + +v+++++ tle +++ +e+ + +v    fn  Gd  ++Sv d  
    EFC39248.1 552 DRQVKIWETSTLECIHSFEEHKD-QVWGLSFNTSGDS-LISVSDDM 595
                   46899****************99.99*********97.68998765 PP

>> HPS3_N  Hermansky-Pudlak syndrome 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.4   0.0    0.0024       2.9      19      75 ..     324     379 ..     315     387 .. 0.82
   2 ?    4.9   0.0     0.014        17      28      74 ..     417     463 ..     400     470 .. 0.77
   3 ?    1.8   0.0      0.12   1.5e+02      29      80 ..     544     595 ..     534     601 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0024
      HPS3_N  19 eptavcaagdkLlvatesgcvevydleeeeckvlcrfstvdkvlkiaysesGdyvat 75 
                  + av++a+dk++ ++ + ++ v+ l++ e  ++ +   +  +++i+ +++G+yvat
  EFC39248.1 324 SVFAVTCAQDKIITGSVDSSIKVWRLDNFELALTLEGHRL-GIISIVSDQTGKYVAT 379
                 56799*********************86666655554444.4889***********9 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.014
      HPS3_N  28 dkLlvatesgcvevydleeeeckvlcrfstvdkvlkiaysesGdyva 74 
                 ++L  +t sg v ++++++ e+++    +    ++++ays++G+y+a
  EFC39248.1 417 QHLATGTRSGNVNIFNVQTGEKEQSLDTQKKTFIMSVAYSNCGKYLA 463
                 34777888999******99888875555556668899********98 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.12
      HPS3_N  29 kLlvatesgc.vevydleeeeckvlcrfs.tvdkvlkiaysesGdyvatlEekn 80 
                 +++ + + ++ v +++ ++   + +++f+   d+v+ ++++ sGd ++++ +++
  EFC39248.1 544 QIFASGSADRqVKIWETST--LECIHSFEeHKDQVWGLSFNTSGDSLISVSDDM 595
                 4665555554488888765..455568862579**************9987766 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   2.3e-06    0.0028       1      74 [.      45     122 ..      45     243 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 2.3e-06
                      EEEETTTSHHHHHHHHHHHHH.B-SEEEEEES-HHHHHHHHHH.........-TTEEEE....E--TT-HHHHHHHTT CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkk.kpkkiillerdElklyeieke...leeelkkkklkveivpvigdvrdkerlekale 74 
                      +++tG++  iG +l++++l +   +ki+   ++E+++ + +++      +++++ ++++++++++d+ + + ++++l 
       EFC39248.1  45 IVITGGTRGIGFALIKELLINyPNHKIVYTGTSENSITKSKEQfvkEIPNFDSNWYNTRLFACVCDISNYNDIHQVLI 122
                      79***************99883556888899*********9995433345666778889999********99999863 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.25     3e+02     191     216 ..     366     391 ..     324     397 .. 0.71
   2 ?    3.7   0.0      0.02        24     192     222 ..     409     439 ..     386     442 .. 0.79
   3 !    6.7   0.2    0.0025         3     179     246 ..     439     500 ..     432     513 .. 0.76
   4 ?    4.3   0.1     0.014        17     172     233 ..     513     572 ..     502     581 .. 0.70

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.25
    Ge1_WD40 191 veaafspdGtalatasedGevkffqv 216
                 ++ +    G  +at+s+d +++ + +
  EFC39248.1 366 ISIVSDQTGKYVATSSMDSVIRVWDI 391
                 33333456788999999999999987 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.02
    Ge1_WD40 192 eaafspdGtalatasedGevkffqvyledee 222
                 + afs+d   lat +  G v  f v   ++e
  EFC39248.1 409 TLAFSADAQHLATGTRSGNVNIFNVQTGEKE 439
                 568*********************9887665 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0025
    Ge1_WD40 179 egllkieehsliveaafspdGtalatasedGevkffqvyledeeeprCLheWkPhdGkslssllfldn 246
                 e  l  ++++ i++ a+s  G  la   +dG v  f +        + +h+   h   s+ s++f ++
  EFC39248.1 439 EQSLDTQKKTFIMSVAYSNCGKYLACGGQDGSVCVFDIST-----SKLMHHLEGHS-MSVRSIVFTND 500
                 45678889999**********************9999865.....45666666664.45566666655 PP

  == domain 4  score: 4.3 bits;  conditional E-value: 0.014
    Ge1_WD40 172 lsveeieegllk..ie.ehsliveaafspdGtalatasedGevkffqvyledeeeprCLheWkPh 233
                 ++v +i++g l   ++ +hs + + a sp G   a  s+d +vk +      +++  C+h +  h
  EFC39248.1 513 INVYDINSGSLVksLSgHHSFVLTLAASPTGQIFASGSADRQVKIWE-----TSTLECIHSFEEH 572
                 555566665443123315678899999*************9999885.....4455677777666 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   1.0       1.8   2.1e+03     135     197 ..       8      70 ..       2     162 .. 0.60
   2 ?    2.8   0.1     0.052        62      15     109 ..     335     433 ..     323     445 .. 0.64
   3 !   12.4   0.6     6e-05     0.071       3      77 ..     450     525 ..     448     530 .. 0.88
   4 !    7.1   0.0    0.0025         3       5      68 ..     536     600 ..     532     607 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.8
   WD40_like 135 ysLsesafivfdlfsqnieykisvkdiktfeiienkdilligtegeililkknvilqkidveg 197
                   Ls  a iv+ +     ++k++++  + +++  + +i++ g    i     +++l ++  + 
  EFC39248.1   8 IILSVLAVIVYVVRKMMVKRKLKFHLKSDLSKKSQLNIVITGGTRGIGFALIKELLINYPNHK 70 
                 557777777777777777777777777777777667777666655555544444554444444 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.052
   WD40_like  15 ilyGgkddkctvlkleslesvsivesfedSvifvkllddd.lilvvtlDGtillsllenee...evenekieedistvkviddklliGtnkGsiyvfsk 109
                 i+ G+ d  ++v  l++ e+   +e+ +  +i +   +    +   ++D  i   ++e+++   ++e   +e      + + ++l+ Gt  G++ +f+ 
  EFC39248.1 335 IITGSVDSSIKVWRLDNFELALTLEGHRLGIISIVSDQTGkYVATSSMDSVIRVWDIEKGKstiIIEAPPLESWTLAFSADAQHLATGTRSGNVNIFNV 433
                 666777777777777777777777766666664332222213344567888877777777766556666666666666777788888888888888875 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 6e-05
   WD40_like   3 iYsidiskkgslilyGgkddkctvlkleslesvsivesfedSvifvkllddd.lilvvtlDGtillslleneeeve 77 
                 i s+ +s+ g++++ Gg+d  + v+++ + +++  +e+ + Sv  + + +d   ++ ++ D  i  ++++ +  v+
  EFC39248.1 450 IMSVAYSNCGKYLACGGQDGSVCVFDISTSKLMHHLEGHSMSVRSIVFTNDSqRLISASDDKHINVYDINSGSLVK 525
                 67999***************************************99999988466667788889889888877665 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.0025
   WD40_like   5 sidiskkgslilyGgkddkctvlkleslesvsivesfedSvifvkl.ldddlilvvtlDGtills 68 
                 ++  s+ g++++ G+ d ++++ ++ +le + ++e+ +d v    +  ++d ++ v+ D  i+++
  EFC39248.1 536 TLAASPTGQIFASGSADRQVKIWETSTLECIHSFEEHKDQVWGLSFnTSGDSLISVSDDMSIVQY 600
                 5677999********************************99876662456677777777666655 PP

>> Frtz  WD repeat-containing and planar cell polarity effector protein Fritz
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.1     0.094   1.1e+02      72     103 ..     264     298 ..     243     321 .. 0.77
   2 ?    1.0   0.0     0.083     1e+02     264     289 ..     325     350 ..     319     398 .. 0.77
   3 ?    8.2   0.1   0.00056      0.67     260     329 ..     448     519 ..     441     530 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.094
        Frtz  72 kvvidkslvGklisekitd...avltdsfiilsfl 103
                 + v+ k+l+Gk++  + td   a+lt   +i+ fl
  EFC39248.1 264 RDVVAKYLIGKVVKTQGTDsfyAFLTPLSVIFRFL 298
                 56889999999999999984445688888888774 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.083
        Frtz 264 slafnpdedkLllGceDssviLydee 289
                 ++a+  ++dk++ G+ Dss+ ++  +
  EFC39248.1 325 VFAVTCAQDKIITGSVDSSIKVWRLD 350
                 689999*************9887654 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00056
        Frtz 260 aqvislafnpdedkLllGceDssviLydeerk..itklvkaevvPsliswhpdsaillvasergelqifDla 329
                 + ++s+a+++    L  G +D+sv+++d ++   + +l    +    i +  ds  l+ as+  ++ ++D+ 
  EFC39248.1 448 TFIMSVAYSNCGKYLACGGQDGSVCVFDISTSklMHHLEGHSMSVRSIVFTNDSQRLISASDDKHINVYDIN 519
                 568999999999****************754322667778899999999*********************96 PP

>> Hira  TUP1-like enhancer of split
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.25     3e+02      22      49 ..     375     401 ..     365     435 .. 0.65
   2 ?   -0.2   0.0      0.56   6.7e+02      15      42 ..     410     437 ..     399     447 .. 0.81
   3 ?    7.4   0.1    0.0027       3.2      20      92 ..     458     533 ..     445     538 .. 0.69

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.25
        Hira  22 syLlavtsvgllyvWnvkkkkvllppvs 49 
                 +y++  + +  + vW+++k k+++   +
  EFC39248.1 375 KYVATSSMDSVIRVWDIEKGKSTI-IIE 401
                 566666667778899998888876.444 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.56
        Hira  15 sfLessgsyLlavtsvgllyvWnvkkkk 42 
                   +++  ++L+  t++g++ ++nv++ +
  EFC39248.1 410 LAFSADAQHLATGTRSGNVNIFNVQTGE 437
                 556677899***************8865 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0027
        Hira  20 sgsyLlavtsvgllyvWnvkkkkvllppvslapllssssrsseke....ltrapavtsasltsnGvpivtlsngdgy 92 
                 +g+yL++  ++g+++v+++ + k++++ +  +  ++s   +++++    ++++++++   ++s G+ +  ls  +++
  EFC39248.1 458 CGKYLACGGQDGSVCVFDISTSKLMHHLEGHSMSVRSIVFTNDSQrlisASDDKHINVYDINS-GSLVKSLSGHHSF 533
                 789**********************97555555555444444443445466666666666653.6666666666666 PP

>> DUF1829  Domain of unknown function DUF1829
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.3     0.037        44      18      67 ..      83     133 ..      78     140 .. 0.84
   2 ?    5.9   0.0     0.015        18      52      81 ..     491     520 ..     478     524 .. 0.89

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.037
     DUF1829  18 kqperlikvinnpnknavkkalfawe.DvkeareensklyvilnDkekkis 67 
                 k++e+++k i n + n +++ lfa   D+ +++++++ l+ ++ ++ ++++
  EFC39248.1  83 KSKEQFVKEIPNFDSNWYNTRLFACVcDISNYNDIHQVLIPFIKNNLNQVD 133
                 789********************9644*****9999999988877766665 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.015
     DUF1829  52 nsklyvilnDkekkisseiedaleeydikv 81 
                 +++ +v+ nD+++ is++  + ++ ydi++
  EFC39248.1 491 SVRSIVFTNDSQRLISASDDKHINVYDINS 520
                 67899**********************986 PP

>> Clathrin-link  Clathrin, heavy-chain linker
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   1.0   0.00082      0.99       4      17 ..     121     134 ..     120     134 .. 0.92
   2 ?    0.9   0.1      0.25     3e+02      12      21 ..     349     358 ..     348     358 .. 0.88
   3 ?   -1.7   0.1       1.6   1.9e+03       4       9 ..     597     602 ..     596     602 .. 0.89

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00082
  Clathrin-link   4 IIPYIlntLnNpdL 17 
                    +IP+I+n+Ln +dL
     EFC39248.1 121 LIPFIKNNLNQVDL 134
                    5*********9998 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.25
  Clathrin-link  12 LnNpdLALrl 21 
                    L N +LAL l
     EFC39248.1 349 LDNFELALTL 358
                    89******87 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 1.6
  Clathrin-link   4 IIPYIl 9  
                    I++Y++
     EFC39248.1 597 IVQYVC 602
                    9****7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (608 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       817  (0.0455686); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.81u 0.34s 00:00:01.15 Elapsed: 00:00:00.52
# Mc/sec: 3493.52
//
Query:       EFC39249.1  [L=416]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1433  (0.0799264); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.35s 00:00:01.06 Elapsed: 00:00:00.55
# Mc/sec: 2257.22
//
Query:       EFC39250.1  [L=216]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.9e-21   75.7   0.1    1.2e-17   64.0   0.0    2.1  2  Ras          Ras family
    6.7e-07   29.6   0.0      0.013   15.7   0.1    2.3  2  Roc          Ras of Complex, Roc, domain of DAPkinase
    6.6e-05   22.9   0.0       0.36   10.7   0.0    2.2  2  RsgA_GTPase  RsgA GTPase
     0.0023   17.5   0.0       0.17   11.4   0.0    2.1  2  GTP_EFTU     Elongation factor Tu GTP binding domain
  ------ inclusion threshold ------
       0.02   14.4   0.0        0.1   12.1   0.0    1.9  2  FeoB_N       Ferrous iron transport protein B
      0.022   14.8   0.0      0.035   14.2   0.0    1.4  1  MMR_HSR1     50S ribosome-binding GTPase
      0.053   13.3   0.0       0.13   12.0   0.0    1.6  1  AAA_29       P-loop containing region of AAA domain
      0.075   13.4   0.0       0.11   12.9   0.0    1.2  1  AAA_16       AAA ATPase domain
      0.084   12.6   0.0        3.9    7.1   0.0    2.1  2  AAA_24       AAA domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.1   0.00027      0.54       1      21 [.      43      63 ..      43      72 .. 0.85
   2 !   64.0   0.0     6e-21   1.2e-17      72     158 ..      97     194 ..      82     197 .. 0.92

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00027
                EEEEEESTTSSHHHHHHHHHH CS
         Ras  1 KlvlvGdsavGKtslllrfvk 21
                +++++Gd++vGK+sl+ +  +
  EFC39250.1 43 RILVLGDESVGKSSLIDKVLD 63
                589************977665 PP

  == domain 2  score: 64.0 bits;  conditional E-value: 6e-21
                 ESEEEEEEETTBHHHHHTHH.HHHHHHHHHSTTTSEEEEEEETTTGGG..........G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHH CS
         Ras  72 aegillvyditsresfenvk.kwveeikrvaeenvpivLvGnKvDlee..........kravsteegeelakelg.lkfletSAktnenveeafeellr 158
                 ++++l++y+i s +sfenvk +++ e++   + n+pi+LvG+K+Dl +           r+vs+++ge+la++++ + f+e+S kt e++e++++ l+r
  EFC39250.1  97 VDCCLICYSIASWKSFENVKkRYIPEVSYFSP-NIPIILVGTKADLGDnerrsyygdlMRKVSFDDGETLARQINaISFIEISSKTGEGFEDLVDFLIR 194
                 68******************89******9999.7*****************************************9**************998877765 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.1   6.7e-06     0.013       1      23 [.      43      65 ..      43      94 .. 0.86
   2 !   12.0   0.0   9.4e-05      0.19      81     120 .]      98     141 ..      87     141 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 6.7e-06
                EEEEESSTTSSHHHHHHCHCT-C CS
         Roc  1 KvvlvGdsgvGKtsllkrfvedk 23
                +++++Gd++vGK+sl++++++++
  EFC39250.1 43 RILVLGDESVGKSSLIDKVLDNS 65
                689***************99876 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 9.4e-05
                 CEEEEEEE...GHHHHCH.HHHHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  81 alailvyd...srssenl.keWlkelkkvagkspvilvgnkiDl 120
                 ++++++y     +s+en+ k+++ e++  ++++p+ilvg+k+Dl
  EFC39250.1  98 DCCLICYSiasWKSFENVkKRYIPEVSYFSPNIPIILVGTKADL 141
                 467777764434467887367*********************95 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.1   0.00025       0.5      89     122 ..      30      64 ..      12      89 .. 0.79
   2 !   10.7   0.0   0.00018      0.36      15      97 ..      96     192 ..      87     198 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00025
                  THHHHHH.HCTTSEEEEECSTTSSHHHHHHHHCTT CS
  RsgA_GTPase  89 gleelke.llkdktsvlvGqSGvGKStLinallpe 122
                  ++++l+  +++++ ++++G   vGKS+Li+++l +
   EFC39250.1  30 EISKLEFnNFTQSRILVLGDESVGKSSLIDKVLDN 64 
                  555665414556777788************98876 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00018
                  S--EEEEEEESTTTT--HHHHHHHH..HHHHHTT-EEEEEEE-GGG--HHH...........HHHHHHHHHHHTT.SEEEE--TTTHTTHHHHHHHC CS
  RsgA_GTPase  15 NvdqllivvslkepelslnlldrfL..vlaeekgiepvivlnKiDlleeee...........eleelkeelealg.yevllvsaktkegleelkell 97 
                   vd +li+ s+++ +  +n  +r++  v + + +i++++v +K+Dl ++e+           ++++ ++  ++++ ++++ +s+kt+eg+e+l + l
   EFC39250.1  96 PVDCCLICYSIASWKSFENVKKRYIpeVSYFSPNIPIILVGTKADLGDNERrsyygdlmrkvSFDDGETLARQINaISFIEISSKTGEGFEDLVDFL 192
                  59999*******9999999999**9556677899**************9999999999998866666777777764578899999999999998766 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.016        31       5      30 ..      43      68 ..      40      86 .. 0.84
   2 !   11.4   0.0   8.6e-05      0.17     122     190 ..     129     194 ..     123     196 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.016
                EEEEEESTTSSHHHHHHHHHHHTTSS CS
    GTP_EFTU  5 nigiighvDhGKtTLtdrLlyktgai 30
                 i ++g+   GK++L+d++l ++   
  EFC39250.1 43 RILVLGDESVGKSSLIDKVLDNSTGF 68
                588999999*********99877655 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 8.6e-05
                 TTEEEEEEESCGSTHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHHHHH CS
    GTP_EFTU 122 gvpiivfiNKmDrlkaelkeiveevkqklsrkeeklekygekgekevpvvfgSalkgegvktllealve 190
                 ++pii++ +K+D  ++e +    ++ +k+s ++++  + +    + ++++ +S+++geg+++l++ l++
  EFC39250.1 129 NIPIILVGTKADLGDNERRSYYGDLMRKVSFDDGETLARQI---NAISFIEISSKTGEGFEDLVDFLIR 194
                 899***********************999555555544443...479******************9986 PP

>> FeoB_N  Ferrous iron transport protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   5.1e-05       0.1       2      38 ..      43      83 ..      42     130 .. 0.68
   2 ?   -0.1   0.0      0.31   6.1e+02     128     154 ..     163     190 ..     154     192 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.1e-05
                EEEEEESTTSSHHHHHHHH....HTTSEEEEESTTSSSEEE CS
      FeoB_N  2 tvalvGnpnvGkttlfnal....tgakqkvgNwpGvtvekk 38
                ++ ++G+  vGk++l++++    tg ++ v N+ G t    
  EFC39250.1 43 RILVLGDESVGKSSLIDKVldnsTGFEKGVLNYCGNTLTFI 83
                58899**********9887555589999********98643 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.31
                 HHHHHHHT.S-EEEEBTTTTBTHHHHHH CS
      FeoB_N 128 kkLsekLg.vpvvktsakkkegieellk 154
                 ++L+++++ +  +++s+k++eg+e+l++
  EFC39250.1 163 ETLARQINaISFIEISSKTGEGFEDLVD 190
                 5677777647899**********99976 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   1.8e-05     0.035       1      45 [.      43      92 ..      43     127 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.8e-05
                EEEEEESTTSSHHHHHHHHHTS....TEEESSSTTSSSSE.EEEEEEETT CS
    MMR_HSR1  1 evaivGrpNvGKStLinaltge....kaivsdkpgtTrdi.negrvklkg 45
                +++++G   vGKS+Li + +++    +  v ++ g T++  n + v++++
  EFC39250.1 43 RILVLGDESVGKSSLIDKVLDNstgfEKGVLNYCGNTLTFiNLIDVSIRK 92
                6899***************9865555678899999998865666666554 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   6.5e-05      0.13      22      40 ..      42      59 ..      29      63 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 6.5e-05
      AAA_29 22 kgatlltGpsGsGKSTllD 40
                +  +l+ G+  +GKS+l+D
  EFC39250.1 42 S-RILVLGDESVGKSSLID 59
                3.59*************** PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   5.6e-05      0.11      25      47 ..      42      64 ..      29      92 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 5.6e-05
      AAA_16 25 elvllsGesGvGKsslvrellra 47
                + +l+ G+  vGKssl++++l+ 
  EFC39250.1 42 SRILVLGDESVGKSSLIDKVLDN 64
                5699***************9974 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0     0.002       3.9       3      24 ..      42      63 ..      40     119 .. 0.78
   2 ?    3.7   0.0     0.022        44     149     184 ..     174     205 ..     153     212 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.002
      AAA_24  3 lkiliyGpsgiGKTtlakelgp 24
                 +il+ G++ +GK++l+ +  +
  EFC39250.1 42 SRILVLGDESVGKSSLIDKVLD 63
                589*************998833 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.022
      AAA_24 149 epklgkktanelkeevDlvlranlkredkvgervlk 184
                  +++++kt++ ++  vD+++r++l     + e +lk
  EFC39250.1 174 FIEISSKTGEGFEDLVDFLIRVQLL----SKEIILK 205
                 47899****************9985....3444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (216 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       382  (0.0213063); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.56u 0.33s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1217.04
//
Query:       EFC39251.1  [L=1605]
Description: guanylyl cyclase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-15   57.3   0.1    4.4e-10   39.5   0.0    2.6  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
      0.011   15.6   0.4        1.7    8.5   0.3    2.6  2  Bac_DnaA       Bacterial dnaA  protein
       0.05   14.0   0.0       0.17   12.2   0.0    2.0  1  AAA_16         AAA ATPase domain
      0.081   13.1   0.3       0.41   10.9   0.3    2.2  1  TPR_2          Tetratricopeptide repeat
      0.095   13.0   0.2        1.5    9.1   0.1    2.6  2  DUF1363        Protein of unknown function (DUF1363)
        5.9    5.7   8.9        9.4    5.1   8.9    1.2  1  DUF4639        Domain of unknown function (DUF4639)


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1     5e-06     0.015       8     123 ..     183     299 ..     178     346 .. 0.82
   2 !   39.5   0.0   1.5e-13   4.4e-10      97     178 ..     487     569 ..     400     573 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 5e-06
  Guanylate_cyc   8 evtilFadIvgftalssahs.....pievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmleal..eevaves 96 
                    e ++l +dI gft l +  s      + + k +n +++ + e + ++ +   k+ Gd        +++ ++ + +++e+aL + +++  + ++v++
     EFC39251.1 183 ETCVLMIDISGFTPLTESLSkqpngVELLTKYINAYFTGLIEYIYSYSGDIEKFAGDG------QNKSLKELVLSAMECALSIQKNDklRFFKVND 272
                    6799***********9999999884455678999999999999999999999999995......55566778999999999998877557889999 PP

  Guanylate_cyc  97 keglkvrvGihtGpvvagviGakkpry 123
                    + +l++  Gi+ G+  + +iG +   y
     EFC39251.1 273 SISLQIHCGISIGSLTTHHIGGVSNYY 299
                    9*******************9776666 PP

  == domain 2  score: 39.5 bits;  conditional E-value: 1.5e-13
  Guanylate_cyc  97 keglkvrvGihtGpvvagviG.akkprydvwGntvnlAsrm..estgkagkiqvseetyellkeeqfeltergevevkGkgklet 178
                    + g+k + Gi+tG++++g +G + +++++++G++vnl +r+  es  ++g +   e+ty+ lk  + +++ +++++vkGk++l+ 
     EFC39251.1 487 ELGIKGGLGISTGKCFIGNVGsMYRKEFTIYGDKVNLSARLmkESEKHDGMVLCEEDTYSKLK--GAKIEILDPIKVKGKSNLIN 569
                    56677799*************999****************84566677788888*********..999999*********98875 PP

>> Bac_DnaA  Bacterial dnaA  protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.011        32      37      79 ..     640     679 ..     624     711 .. 0.74
   2 ?    8.5   0.3   0.00056       1.7      89     174 ..     863     947 ..     848     987 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.011
                 EEEE-SSSSSHHHHHHHHHHHHHHHSSSS-EEEEEHHHHHHHH CS
    Bac_DnaA  37 lfiygevGlGktHLlkaignevlenapelrvvYltaeeFlnel 79 
                 + i g+vGlGkt Ll  ++   +++      vY++  +F + +
  EFC39251.1 640 ITIRGDVGLGKTDLLTRLSDIWKTK---IATVYISPPQFETPF 679
                 5688***********9887654433...334666666666655 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00056
                 HHHHHHHTT-SEEEEE-GGGGTT-HHHHHHHHHHHHHHHTTT-EEEEEESS-TTT-SS--HHHHHHHHSSEEEE-----HHHHHHH CS
    Bac_DnaA  89 eefkeklrkvDvLliDDiqflagkektqeelfhtfnalleegkqvvlssDrsPkeleeledrlrsrfeaGlvvdieppdletrlai 174
                 e +k ++++ Dv   D ++f+ +k++ ++ + +++ ++l+++k+ ++  +    + + l+  + s ++a ++ +i++ d et++a+
  EFC39251.1 863 EYLKLFYKASDVH-ADALEFVFEKSQGNQLFTKMICSFLKDNKRYLIEDETLKLKNTMLDVEIVSSMSAYVQRKIDRLDDETKIAL 947
                 4567778888875.79******************************9998888899999***********************9986 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   5.8e-05      0.17      18     159 ..     632     806 ..     606     815 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.8e-05
      AAA_16  18 rvrsgrpelvllsGesGvGKsslvrellralekdggiflrgkcdqlesaipy...salaqalareellrqlldeaesaeleawrekleeala....... 106
                 +v ++++  + ++G+ G GK+ l+++l + ++++ + +++    q+  ++p+   +  +++++ e+++++ + e++ +++e   ++l+ + +       
  EFC39251.1 632 AV-KDSSKFITIRGDVGLGKTDLLTRLSDIWKTK-IATVYISPPQF--ETPFysmLSNVRICFCEHIYKKKNIELDYSKVESIFKALTIQEKeelvrek 726
                 23.333399*******************999988.999********..888865533455555667777777775555555555544444334433333 PP

      AAA_16 107 ...........................avpelagaeasrllellkrllallsrderplvlvlDdlqwadeaslqllaaLl 159
                                               ++ + +a+ ++  l ++ +    +++p+ ++ Dd q  d+ +++l  ++l
  EFC39251.1 727 tdesditymyllnnifgvkfksngellTKEQIVDISARIMCKFLVNCWVSFGYGSQPWFMLYDDYQYTDPFTRKLVTLFL 806
                 33444444444444444444432222222222222224444444444433334444777777777777777777766665 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.3   0.00014      0.41       6      25 ..    1322    1341 ..    1318    1346 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00014
       TPR_2    6 nlGlayyklgdyeeAleafe 25  
                  + +++ y+lg++eeA+++fe
  EFC39251.1 1322 YAARSSYALGKFEEARAYFE 1341
                  679999*************8 PP

>> DUF1363  Protein of unknown function (DUF1363)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.1    0.0005       1.5      53     104 ..     687     739 ..     681     748 .. 0.86
   2 ?    0.2   0.0      0.28   8.4e+02      24      78 ..    1050    1105 ..    1038    1124 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0005
     DUF1363  53 ticfsthlhkrsnrrldr.rceyifgicsikgnsaarrkkflktplcqrylnn 104
                  icf  h++k+ n  ld  ++e if   +i+ +    r+k  ++ +   yl n
  EFC39251.1 687 RICFCEHIYKKKNIELDYsKVESIFKALTIQEKEELVREKTDESDITYMYLLN 739
                 69***************5389***********999999999999999888754 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.28
     DUF1363   24 ctphesfyylsin.hdlkareaqnnntnsdticfsthlhkrsnrrldrrceyifgi 78  
                  ++ h s+yy  i   ++ + +  +++ +   +c++ hl +++   +dr+ + i  i
  EFC39251.1 1050 ASLHYSYYYDDIIlEEVLTGDPLEKEVELHNLCVAYHLIEKAITLFDRKSKQIDTI 1105
                  56689999987641667788888999999999*****9999999999998877655 PP

>> DUF4639  Domain of unknown function (DUF4639)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   8.9    0.0031       9.4     152     283 ..      22     155 ..       7     180 .. 0.68

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0031
     DUF4639 152 gsvdqiplgrswldrgsqeqtessekspelrvtpgppptpelfqeagprdpleeldgqers.klssagslnaslqlsvevasaespesslelsqvaspq 249
                 +  d  + ++ + d++s++ + s + s++ ++ + +pp+ e   +a p++++++ +++er  +  s +sln+++ +    +  ++ ++  ++++ +s+ 
  EFC39251.1  22 QIIDAPQKRKVYRDEKSKQSIVSEKASSNHKISS-SPPKDEETTKASPKQAIDQQEKKERTeTKNSSQSLNETVTKKSSNELYNDLKPNENMTNSVSQD 119
                 4455555667788999999998988887777655.5677788899********9999999835678889999887666666666666666666666666 PP

     DUF4639 250 asaeraqplssqlsl..edlylclpqpdaagdrlel 283
                  ++  + ++s+  sl  + + ++   +++ +d+le 
  EFC39251.1 120 LKKVDSVAFSFVKSLlpKRFTFSSDIEKKEQDQLEI 155
                 655555555554443115566666566666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1605 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1913  (0.106699); expected 358.6 (0.02)
Passed bias filter:                      624  (0.0348039); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.16u 0.36s 00:00:01.52 Elapsed: 00:00:00.52
# Mc/sec: 9262.17
//
Query:       EFC39252.1  [L=504]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-25   89.3   2.4    1.1e-23   83.2   0.2    2.9  3  DUF4209   Domain of unknown function (DUF4209)
  ------ inclusion threshold ------
      0.045   12.7   0.1       0.09   11.7   0.1    1.4  1  HSL_N     Hormone-sensitive lipase (HSL) N-terminus


Domain annotation for each model (and alignments):
>> DUF4209  Domain of unknown function (DUF4209)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.2   0.2   1.3e-27   1.1e-23       1      89 []      68     163 ..      68     163 .. 0.94
   2 !    5.3   0.1    0.0026        23      52      87 ..     326     361 ..     262     363 .. 0.78
   3 ?   -3.8   0.0       1.8   1.6e+04      24      42 ..     427     445 ..     423     448 .. 0.74

  Alignments for each domain:
  == domain 1  score: 83.2 bits;  conditional E-value: 1.3e-27
     DUF4209   1 lErllrdlielagkktrkkkkekeklls........dlLaseelkeilgeelalilrvllgpprglNLRNvvwHGfiseeefsksllsllllllasl 89 
                 lEr l+d i+ ++  ++++k++++++ +        +lL+++elk+i+gee++l+lr+l+gp +++NLRNv++HGfi+e+ef++++lsl+lll+ sl
  EFC39252.1  68 LERGLQDSIY-IDLVHNNDKQKVQQFEDfsklpkfsELLTMKELKDIYGEEVTLLLRCLVGPLNSINLRNVSLHGFINEREFQDCYLSLILLLVPSL 163
                 7*********.8888899999988888888888999*********************************************************9875 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0026
     DUF4209  52 lgpprglNLRNvvwHGfiseeefsksllslllllla 87 
                 l   +++ +R ++ HG i+ e++++ l+  ++ l++
  EFC39252.1 326 LIWVESPRVRDLISHGNINIETIPQALVDEIVKLMF 361
                 446677789*****************9999988876 PP

  == domain 3  score: -3.8 bits;  conditional E-value: 1.8
     DUF4209  24 ekllsdlLaseelkeilge 42 
                 +++ +d+++++++kei +e
  EFC39252.1 427 KNIPDDIFNLPNFKEIRDE 445
                 4556799999999998665 PP

>> HSL_N  Hormone-sensitive lipase (HSL) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1     1e-05      0.09     223     248 ..     466     491 ..     461     499 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1e-05
       HSL_N 223 tqnadveFckaFWnltEsellkklps 248
                   +  +eF+k+F+n+ E+++ k+l +
  EFC39252.1 466 KLSEHIEFVKSFYNIEENQMTKHLGN 491
                 56678******************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (504 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.25s 00:00:00.82 Elapsed: 00:00:00.43
# Mc/sec: 3482.67
//
Query:       EFC39253.1  [L=300]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.2e-42  143.2   1.2    1.1e-41  142.9   1.2    1.1  1  NmrA             NmrA-like family
    6.4e-20   71.8   0.4    1.8e-19   70.4   0.2    1.9  1  NAD_binding_10   NAD(P)H-binding
      2e-08   34.0   0.1      2e-07   30.7   0.1    2.4  2  Epimerase        NAD dependent epimerase/dehydratase family
    1.8e-06   28.1   0.4    1.8e-06   28.1   0.4    2.0  2  DapB_N           Dihydrodipicolinate reductase, N-terminus
    7.6e-06   26.0   1.3    9.8e-06   25.7   0.4    1.6  2  Shikimate_DH     Shikimate / quinate 5-dehydrogenase
    0.00031   20.3   1.2       0.16   11.4   0.1    3.0  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    0.00052   20.4   0.1     0.0012   19.3   0.1    1.7  1  Semialdhyde_dh   Semialdehyde dehydrogenase, NAD binding doma
    0.00097   19.4   1.3     0.0017   18.6   0.3    1.9  2  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
     0.0013   17.9   0.9     0.0032   16.7   0.2    2.0  2  NAD_binding_4    Male sterility protein
      0.003   18.3   0.9       0.01   16.6   0.1    2.2  2  GARS_N           Phosphoribosylglycinamide synthetase, N doma
     0.0045   17.7   3.4       0.23   12.2   0.7    2.3  2  DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomer
  ------ inclusion threshold ------
      0.013   15.6   0.4      0.034   14.2   0.4    1.7  1  Ldh_1_N          lactate/malate dehydrogenase, NAD binding do
      0.021   14.0   0.9        1.5    7.9   0.2    2.7  2  Polysacc_synt_2  Polysaccharide biosynthesis protein
      0.023   14.8   2.7       0.15   12.2   0.3    2.6  2  DUF211           Uncharacterized ArCR, COG1888
      0.046   13.6   1.5      0.052   13.5   0.4    1.7  2  KR               KR domain


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.9   1.2   9.4e-45   1.1e-41       1     230 [.       6     230 ..       6     253 .. 0.90

  Alignments for each domain:
  == domain 1  score: 142.9 bits;  conditional E-value: 9.4e-45
                 EEESSTTSHHHHHHHHHHHH.HT-EEEEEES-S-SHHHHHHHHSTTEEEES-TT-H.HHHHHHHTT-SEEEE---GGS-HHHH.HHHHHHHHHHHS-SE CS
        NmrA   1 IlviGaTGrqGksvvrallk.aghkvralvRdtkselakslkeaGvelvkgdlddk.eslvealkgvdvvfsvtgfyskeied.gkklvdAakeaGvkh 96 
                 +lv+GaTGr+G+ +++all+    +v al+R+ ++ +a++lke+Gv+l++g l+d  e l++a ++vdv++s++   ++ i d + +l +Aak+aGvk+
  EFC39253.1   6 VLVVGATGRLGSLITSALLNkPTVQVSALIRKGSETKAEQLKEKGVQLISGALNDSvEELQQACQNVDVIISAVIGSEDTILDgQLRLLEAAKKAGVKR 104
                 79***************9987899****************************9985499*************998887777762568************ PP

                 EEEEE---GG.GT.SSS---TTTHHHHHHHHHHHHCTS-EEEEEE-EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE-HHHHHHHHHHHHHH CS
        NmrA  97 fiySslgddndrsnaeepavphfdsKaeieeyvralgipytfvyagffmenflsllaqlkvgdtappedkvtllgpgnpkavlldaeeDiGafvikilk 195
                 fi+S + +d     a++ +++hfd+  ++ e v+++gi yt+++ g+fme f +++ +  + dt++ +  +t  g +++     ++ eD +++v++++ 
  EFC39253.1 105 FIPSDYSADY--LRASIGDHDHFDMRKQVAEQVKQSGIGYTIFLNGVFMETFFGPFLN--IIDTKNHK--ITYYGSAETLVDT-TTYEDAANYVVEAAL 196
                 *******999..4568889***********************************9999..77777776..6666666643344.478************ PP

                 HHHHHTTEEEEE-SEEE-HHHHHHHHHHHHTS-EE CS
        NmrA 196 dprklkgkriklagntlsgneivelfekkigktvk 230
                 dp++l+ k++ ++g+ ++++++++ +e+++g +++
  EFC39253.1 197 DPEQLN-KIVTVSGDRVTYTQLAQQIEQVTGHKIT 230
                 ***994.78999*******************9986 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.4   0.2   1.5e-22   1.8e-19       1     148 [.      10     152 ..      10     198 .. 0.71

  Alignments for each domain:
  == domain 1  score: 70.4 bits;  conditional E-value: 1.5e-22
                     TTTSHHHHHHHHHHHHC-T-EEEEEETT..HHHCHHHHCTTTCEEEE--TT-.CCHHHHHHTT-SEEEES-.--TCCHHHHHHHHHHHHHHCT-- CS
  NAD_binding_10   1 GAtGkvGrllvkellargghevtalvRn..peklaeleaeeglevvegdvtd.vedlaealkgadaVvsal.ggggkdeegaknivdaakeagvk 91 
                     GAtG+ G+l+++ ll++  ++v al+R+  + k+++l+ e+g+++++g ++d ve+l++a++++d+++sa+ g++++  +g  ++++aak+agvk
      EFC39253.1  10 GATGRLGSLITSALLNKPTVQVSALIRKgsETKAEQLK-EKGVQLISGALNDsVEELQQACQNVDVIISAViGSEDTILDGQLRLLEAAKKAGVK 103
                     9**************************95566778886.7**********9847*****************6667779999************** PP

                     EEEEEEETTTTSGCGCHHHHHHHHCCHHHHHHHHHHHHHHHHSSSEEEEEEE-CEE- CS
  NAD_binding_10  92 RfvlvsaigvgdevpgefgewnkellkaylaakraaeellrasgldwTivrpggLtd 148
                     Rf+   +   +     + g+       + ++  ++ +e +++sg+ +Ti   g +++
      EFC39253.1 104 RFIPSDYSADY--LRASIGDH------DHFDMRKQVAEQVKQSGIGYTIFLNGVFME 152
                     ***98764433..22233332......234556778888999999999998888544 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.7   0.1   1.7e-10     2e-07       1     111 [.       6     106 ..       6     109 .. 0.90
   2 ?    0.1   0.0      0.39   4.7e+02     194     231 ..     163     200 ..     129     208 .. 0.79

  Alignments for each domain:
  == domain 1  score: 30.7 bits;  conditional E-value: 1.7e-10
                 EEEETTTSHHHHHHHHHHHHCT.SEEEEEES-STTTTCHHCHHC..EEEE--TT-HH.HHHHHHHHHT-SEEEE--S---HHHHHHSHHHHHHHHTHHH CS
   Epimerase   1 ilVtGatGfiGsalvkallekg.yevigldrlssasntarledl..elveldltdrs.alerlfkeeqpdavihlAavggvaassedpadfieknlqgt 95 
                 +lV+GatG +Gs ++ all+k  ++v +l r+ s+ + ++l+++  +l+ + l d++ +l+++++  ++d++i +  v          +d+i   l g+
  EFC39253.1   6 VLVVGATGRLGSLITSALLNKPtVQVSALIRKGSETKAEQLKEKgvQLISGALNDSVeELQQACQ--NVDVIISA--VI-------GSEDTI---LDGQ 90 
                 79********************777*******99999999999999**********989***999..99*****9..44.......444544...57** PP

                 HHHHHHHHHHTCTEEE CS
   Epimerase  96 lnlleaarkagvkrll 111
                 l+lleaa+kagvkr++
  EFC39253.1  91 LRLLEAAKKAGVKRFI 106
                 **************97 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.39
                 HTTSSSEEEETTST-EEEEEEHHHHHHHHHHHHHHHTT CS
   Epimerase 194 legkqevtllgdgtalRdflyveDvaeaillvlehvda 231
                  ++ +++t++g+ + l d    eD+a+ ++ ++  +++
  EFC39253.1 163 DTKNHKITYYGSAETLVDTTTYEDAANYVVEAALDPEQ 200
                 33336899999999999999999999999888776655 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.1   0.4   1.5e-09   1.8e-06       1      72 [.       4      76 ..       4     102 .. 0.79
   2 ?   -1.5   0.1       2.2   2.6e+03      68      84 ..     175     191 ..     159     226 .. 0.64

  Alignments for each domain:
  == domain 1  score: 28.1 bits;  conditional E-value: 1.5e-09
                EEEEEETTTSHHHHHHHHHHHHSTTEEEEEEEETTCSTTTTTBHHHHSSSS--S-BEB...SSHHHHHHH-SEEE CS
      DapB_N  1 ikvavvGasGrmGkevvkaveeaedlelvaavdrkeselegkdagellglgklgvavt...ddleevlekadvli 72
                +kv+vvGa+Gr+G+ +++a+ +++ ++++a + + + e++++++ e  g++ ++ a++   ++l+++++++dv+i
  EFC39253.1  4 TKVLVVGATGRLGSLITSALLNKPTVQVSALIRKGS-ETKAEQLKE-KGVQLISGALNdsvEELQQACQNVDVII 76
                59***************************9999976.555555544.4444444444422356777777799998 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 2.2
                 -SEEEE-S-HHHHHHHH CS
      DapB_N  68 advliDFTtpeavlenl 84 
                 a+ l+D Tt e + +++
  EFC39253.1 175 AETLVDTTTYEDAANYV 191
                 66677777655554443 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   0.4   8.2e-09   9.8e-06      11      96 ..       2      92 ..       1     106 [. 0.76
   2 ?   -3.0   0.0       5.7   6.8e+03      50      61 ..     215     226 ..     193     246 .. 0.58

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 8.2e-09
                  TT-EEEEES-.SHHHHHHHHHHHCCT-CEEEEEES..SHHHHHHHHHHHT.ET..-EEEEGCGHHHHHHT-SEEEE-SSSSS-SB-HHHHH CS
  Shikimate_DH 11 kekkvlliGa.GemaelvakhLlakgvkkvvvaNR..tlerakelaeelkgee..iealkleelkellaeadvvisataseepilekeeve 96
                  ++ kvl++Ga G++++l++++Ll+k   +v  + R  + ++a++l e+  +    +   ++eel+++ +++dv+isa+  +e  +  ++++
    EFC39253.1  2 SSTKVLVVGAtGRLGSLITSALLNKPTVQVSALIRkgSETKAEQLKEKGVQLIsgALNDSVEELQQACQNVDVIISAVIGSEDTILDGQLR 92
                  678******88**************888887766633789999**98864332013567899***************87666666555554 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 5.7
                   HHHHHHHT.ET- CS
  Shikimate_DH  50 kelaeelkgeei 61 
                    +la++++++  
    EFC39253.1 215 TQLAQQIEQVTG 226
                   445555544433 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.1   0.00013      0.16       1     118 [.       7     102 ..       7     111 .. 0.70
   2 ?    4.8   0.1     0.013        15     202     280 ..     160     239 ..     148     259 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00013
                    EEETTTSHHHHHHHHHHHHC.T-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHTTSH CS
  GDP_Man_Dehyd   1 LiTGiaGfiGsylaelLlek.gyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevqpdevynLAAqshVdvsfekP 95 
                    L+ G +G  Gs ++  Ll+k   +v  ++r+ s+++++++++          + ++l++g l+D  s+e+l + +q            Vdv ++  
     EFC39253.1   7 LVVGATGRLGSLITSALLNKpTVQVSALIRKGSETKAEQLKE----------KGVQLISGALND--SVEELQQACQ-----------NVDVIISAV 79 
                    899***************996789999***999999877754..........346899999999..4555544443...........344444444 PP

                    HHHHHHHTHHHHHHHHHHHHCT. CS
  GDP_Man_Dehyd  96 eytaevnvlGtlrLLeairalgl 118
                        ++ + G lrLLea++++g+
     EFC39253.1  80 IGSEDTILDGQLRLLEAAKKAGV 102
                    44444555566666666666655 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.013
                    HHHHTTS-C-EECTTTT-EEEEEEHHHHHHHHH.HHHHCSS---EEE-TT-EEECHHCHHCCHHCCCHHHHHH....... CS
  GDP_Man_Dehyd 202 arialgkqevlylGnldakRdwghvkDyveamw.lmlqqdkpedyviatgethsvrefvelaflelgktiewegkgeeev 280
                      i+ ++++++y+G  +   d +  +D ++ ++ ++l  ++ +++v  +g+ ++  ++++   + +g +i+ e kg+ e 
     EFC39253.1 160 NIIDTKNHKITYYGSAETLVDTTTYEDAANYVVeAALDPEQLNKIVTVSGDRVTYTQLAQQIEQVTGHKITLERKGNVED 239
                    55677789999*****************99865157888999**************999988888888888876665442 PP

>> Semialdhyde_dh  Semialdehyde dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.1   9.9e-07    0.0012       1      74 [.       5      79 ..       5     114 .. 0.80

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 9.9e-07
                    EEEEETTTSHHHHHHHHHHHCTSSEEEEEEEESTT.TTTSBHHHHSG.GGTTTECEBEEEGGGGGCTT-SEEEE-S CS
  Semialdhyde_dh  1 kvaivGatGyvGqellrlLeehpevelvvllsssr.saGkklaeavk.aleegkdlkvedvdeeelkevdivflal 74
                    kv +vGatG  G+ +   L ++p v++++l+ + +  + ++l+e+    +++  + +ve+  +++ ++vd++++a+
      EFC39253.1  5 KVLVVGATGRLGSLITSALLNKPTVQVSALIRKGSeTKAEQLKEKGVqLISGALNDSVEE-LQQACQNVDVIISAV 79
                    799**************************9976664344444444332666666777777.667779******996 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.3   1.5e-06    0.0017       1      93 [.       6     101 ..       6     109 .. 0.76
   2 ?   -1.4   0.0       2.2   2.6e+03      27      67 ..     204     244 ..     178     260 .. 0.57

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 1.5e-06
                      EEEE--.SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHHHHCHHTTTCEEEEE--TTTHHHHHHHHHTTSSEEEE-SSGG......GHHHHHH CS
  Sacchrp_dh_NADP   1 vliiGa.GsvGqavaellarhfdvdaeitvadrskeklealaakalgvrfeaialdaenyeavLaallkegdlvvnlsppi......ssldvlk 87 
                      vl++Ga G+ G+ ++  l+++  v  ++    r+ ++ +a+  k++gv++++ al+   +e+ L+++++  d++++++           l +l+
       EFC39253.1   6 VLVVGAtGRLGSLITSALLNKPTV--QVSALIRKGSETKAEQLKEKGVQLISGALND-SVEE-LQQACQNVDVIISAVIGSedtildGQLRLLE 95 
                      89**********************..6666666666655555555788888888874.4566.**************98875555555555566 PP

                      HHHHHT CS
  Sacchrp_dh_NADP  88 aCietg 93 
                      a+ ++g
       EFC39253.1  96 AAKKAG 101
                      555555 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.2
                      EEEEESSHHHHHHHHCHHTTTCEEEEE--.TTTHHHHHHHHH CS
  Sacchrp_dh_NADP  27 itvadrskeklealaakalgvrfeaiald.aenyeavLaall 67 
                      i+ ++ ++    +la+++ +v+ ++i+l  + n+e+ L++l+
       EFC39253.1 204 IVTVSGDRVTYTQLAQQIEQVTGHKITLErKGNVED-LKKLI 244
                      444444444444444444444434444431234444.55555 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.2   2.7e-06    0.0032       2      40 ..       9      46 ..       8      77 .. 0.85
   2 ?   -2.5   0.0       1.9   2.3e+03      57      68 ..     199     210 ..     179     251 .. 0.64

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.7e-06
                   E-TTSHHHHHHHHHHHHHS-.TEEEEEE-SSSHHHHHHH CS
  NAD_binding_4  2 TGaTGFLGkvLlekLLrttpevkiyllvRaksgesaeeR 40
                    GaTG LG+ +   LL++ + v++ +l+R+ s+++ae+ 
     EFC39253.1  9 VGATGRLGSLITSALLNKPT-VQVSALIRKGSETKAEQL 46
                   6***************9986.8*********99888774 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.9
                    HHTTTEEEEE-- CS
  NAD_binding_4  57 elaerikvveGD 68 
                    e +++i+ v+GD
     EFC39253.1 199 EQLNKIVTVSGD 210
                    444555555555 PP

>> GARS_N  Phosphoribosylglycinamide synthetase, N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.1   8.4e-06      0.01       2      87 ..       5     112 ..       4     114 .. 0.77
   2 ?   -1.1   0.1       2.9   3.5e+03      24      54 ..     200     231 ..     191     270 .. 0.55

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 8.4e-06
                 EEEEEESSHHHHHHH.HHHTTSTTESEEEEEE--CGG...................TTHHHHHHHHHHCT.ESEEEE-SHHHHHTTHHHHHHHHH..T- CS
      GARS_N   2 kvLvvGsGGRehala.wklaqspkvekvyvapgNagt...................edlealvefakeek.idlvvvGpeapLvaGvadaleeek..gi 77 
                 kvLvvG  GR  +l+  +l ++p+v+ v ++ + ++                    +++e+l + +++ + i  +v+G e+ + +G    le++k  g+
  EFC39253.1   5 KVLVVGATGRLGSLItSALLNKPTVQ-VSALIRKGSEtkaeqlkekgvqlisgalnDSVEELQQACQNVDvIISAVIGSEDTILDGQLRLLEAAKkaGV 102
                 8*********8776615778888887.4444433333379999998888888888655778999999988355789**********9999987766899 PP

                 EEES--CCCC CS
      GARS_N  78 kvfGpskeaA 87 
                 k f ps  +A
  EFC39253.1 103 KRFIPSDYSA 112
                 9999998776 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 2.9
                 TESEEEEEE--CGG.....TTHHHHHHHHHHCTESE CS
      GARS_N  24 kvekvyvapgNagt.....edlealvefakeekidl 54 
                 +++k++++ g+  t     +     +e ++ +ki+l
  EFC39253.1 200 QLNKIVTVSGDRVTytqlaQ----QIEQVTGHKITL 231
                 55666666666666533330....222233333333 PP

>> DXP_reductoisom  1-deoxy-D-xylulose 5-phosphate reductoisomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.7    0.0002      0.23       1      81 [.       6      84 ..       6      99 .. 0.89
   2 ?    6.1   0.1     0.015        18      26      74 ..     203     252 ..     185     268 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.0002
                     EEEESTTSHHHHHHHHHHHHCTTTEEEEEEEESSTHHHHHHHHHHHT-SEEEESSHHHHHHHHHHHHHTTSSSEEEESHHH CS
  DXP_reductoisom  1 vviLGsTGSIGtqtLdvieenpdkfevvalaagsnvellaeqakefkpklvavadeeaaeelkealkekelktevlvGeea 81
                     v+++G+TG +G+   + + ++p + +v+al  +   e+ aeq+ke  ++l++ a ++++eel++a+++ ++ ++ ++G+e 
       EFC39253.1  6 VLVVGATGRLGSLITSALLNKP-TVQVSALIRKG-SETKAEQLKEKGVQLISGALNDSVEELQQACQNVDVIISAVIGSED 84
                     689********99888888888.89****98744.677899*************************999999999999876 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.015
                      EEEEEEE.SSTHHHHHHHHHHHT-SEEEESSHHHHHHHHHHHHHTTSSSE CS
  DXP_reductoisom  26 evvalaa.gsnvellaeqakefkpklvavadeeaaeelkealkekelkte 74 
                      ++v++++     ++la+q+++++ + ++++++ ++e+lk+ +++++ +t+
       EFC39253.1 203 KIVTVSGdRVTYTQLAQQIEQVTGHKITLERKGNVEDLKKLIETTKNTTH 252
                      67777775567899**************************9987555443 PP

>> Ldh_1_N  lactate/malate dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.4   2.9e-05     0.034       1      74 [.       4      76 ..       4      83 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.9e-05
                EEEEEETTTSHHHHHHHHHHHHTTSSSEEEEE-SSHHHHHHHHHHHHHCHCCSTS-EEEEESSGGGGTTESEEE CS
     Ldh_1_N  1 vkvavvGaaGgiGqslalllankkladelaLlDiakekleGvaldlshistflsvkvkvsekeeealkdadvvv 74
                +kv vvGa+G  G+ +  +l+nk+ ++  aL+    ++++++ l  + +++++ +   + e+ ++a++++dv++
  EFC39253.1  4 TKVLVVGATGRLGSLITSALLNKPTVQVSALIRKG-SETKAEQLKEKGVQLISGALNDSVEELQQACQNVDVII 76
                69*********************999977776544.3555555555555555555556666999*******986 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.2    0.0012       1.5       1      44 [.       6      51 ..       6     114 .. 0.78
   2 ?    3.9   0.0     0.021        25     205     253 ..     183     231 ..     181     246 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0012
                     EEEETTTSHHHHHHHHHHHHHB-SEE..EEEES-HHHHHHHHHH.. CS
  Polysacc_synt_2  1 vlvtGagGsiGselvrqilkkkpkki..illerdElklyeiekele 44
                     vlv Ga+G +Gs +++ +l+k   ++  ++ + +E+k  +++++  
       EFC39253.1  6 VLVVGATGRLGSLITSALLNKPTVQVsaLIRKGSETKAEQLKEKGV 51
                     89*****************995555421566778999999998832 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.021
                      -HHHHHHHHHHHHHH--SS-EEEE--.-EEEHHHHHHHH.......... CS
  Polysacc_synt_2 205 tieeavqLvlqalalakggeifvldmGepvkivdlakalielsgleekk 253
                      t e+a++ v++a+   ++ +  v+  G+ v+ ++la+++ +++g++ + 
       EFC39253.1 183 TYEDAANYVVEAALDPEQLNKIVTVSGDRVTYTQLAQQIEQVTGHKITL 231
                      568999******99999999999999************99999987654 PP

>> DUF211  Uncharacterized ArCR, COG1888
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.1      0.21   2.5e+02      30      52 ..      54      77 ..      36      86 .. 0.75
   2 ?   12.2   0.3   0.00013      0.15      11      70 ..     165     226 ..     159     231 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.21
                EE.EEEEEEEEE-SSEEEEEEEEE CS
      DUF211 30 vd.gvnitvkevDketenlkitie 52
                ++ + n +v e+ +  +n++++i 
  EFC39253.1 54 ISgALNDSVEELQQACQNVDVIIS 77
                443568889999999999998886 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00013
                 EESSS-HHHHHHHHHTSTTEE.EEEEEEEE.E-SSEEEEEEEEEESSE-HHHHHHHHHCTT- CS
      DUF211  11 kphepsivelakklaelegvd.gvnitvke.vDketenlkitieGenidyeeieeaieelgg 70 
                 k h+++    a++l ++++ + ++n +v   +D e  n  +t+ G+++ y ++ ++ie++ g
  EFC39253.1 165 KNHKITYYGSAETLVDTTTYEdAANYVVEAaLDPEQLNKIVTVSGDRVTYTQLAQQIEQVTG 226
                 568888888899999988887356665542479999999*******************9976 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.4   4.4e-05     0.052       3      60 ..       6      58 ..       4     102 .. 0.71
   2 ?   -2.6   0.0       3.6   4.3e+03      49      49 ..     218     218 ..     180     254 .. 0.56

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 4.4e-05
                EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE--- CS
          KR  3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaa 60
                +l++G++G LG  ++  l++k   ++  l R+++     +++ ++l+++g++    a+
  EFC39253.1  6 VLVVGATGRLGSLITSALLNKPTVQVSALIRKGS-----ETKAEQLKEKGVQLISGAL 58
                79******************************43.....3344667777776544443 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 3.6
                 H CS
          KR  49 e 49 
                 +
  EFC39253.1 218 A 218
                 2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (300 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1040  (0.0580066); expected 358.6 (0.02)
Passed bias filter:                      620  (0.0345808); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 1953.69
//
Query:       EFC39254.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.016   15.5   6.2      0.016   15.5   6.2    3.5  4  Pet191_N  Cytochrome c oxidase assembly protein PET191


Domain annotation for each model (and alignments):
>> Pet191_N  Cytochrome c oxidase assembly protein PET191
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1      0.45     8e+03      48      55 ..      41      48 ..      38      53 .. 0.73
   2 ?   -0.1   0.3     0.065   1.2e+03      45      58 ..     101     114 ..      75     119 .. 0.65
   3 ?    2.4   0.6     0.011     2e+02      32      55 ..     138     161 ..     129     170 .. 0.84
   4 ?   15.5   6.2     9e-07     0.016       3      54 ..     193     241 ..     191     255 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.45
    Pet191_N 48 kayfeCkr 55
                ++y+ Ck 
  EFC39254.1 41 RKYATCKE 48
                57888885 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.065
    Pet191_N  45 qlrkayfeCkrgll 58 
                 + ++  f+Ck ++l
  EFC39254.1 101 ESKDHIFKCKDEIL 114
                 45566788887776 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.011
    Pet191_N  32 lkekaeelpeeCkqlrkayfeCkr 55 
                 l++k ++++++C +  ++y  C r
  EFC39254.1 138 LDDKISQCDKNCSEWFYKYGLCTR 161
                 567778999*************87 PP

  == domain 4  score: 15.5 bits;  conditional E-value: 9e-07
    Pet191_N   3 sCkdlrealaeClqksdCvkkerktpkeClkekaeelpeeCkqlrkayfeCk 54 
                  C+d +++  +C+ +  C +++ +++++Clk++   +++eC +l k+  +C 
  EFC39254.1 193 VCDDFKKKSLSCVGDIFCAEQQ-QKLQDCLKNS--MFKSECDDLEKTAKRCA 241
                 5*****************8877.77********..9***********99995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       863  (0.0481343); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1668.22
//
Query:       EFC39255.1  [L=230]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.5e-10   39.2  10.3    2.8e-09   37.1  10.3    1.9  1  Rhomboid  Rhomboid family
    2.5e-06   27.6   2.6    2.5e-06   27.6   2.6    2.0  2  DER1      Der1-like family


Domain annotation for each model (and alignments):
>> Rhomboid  Rhomboid family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1  10.3   3.1e-13   2.8e-09      52     147 ..      70     159 ..       4     161 .. 0.89

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 3.1e-13
                 HHHHHHHHHHHHHH-S...-EESSHHHHHHHHHHHHHHHHCCCCGS----HC...CCCCCCCCCCHHHCTSSSTTTHHHHHHHHHHHHHHHHHHCC CS
    Rhomboid  52 lsglagsllsllfsaesesplvGaSGaifgllgallvlvprnrkllrkliiallllllfillnlvlgllpraggvsnlAHlgGllaGlllgllllr 147
                 +sg++ +l++++   e   +++G+SG+if++l ++++   ++ ++l+++i+ +  ++++ill ++  l+p+    s+++Hl+G++ G++++ll+ r
  EFC39255.1  70 ISGIMDGLAQFFGLHE---CSIGFSGVIFSYLTIASTDTSQTTNSLFGMISVPSKYYPWILLLVTSFLFPSS---SFVGHLFGIISGYIFVLLFER 159
                 5677777777766666...9***************************************************9...***************998765 PP

>> DER1  Der1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1     0.058   5.2e+02      70      97 ..       7      34 ..       2      55 .. 0.56
   2 !   27.6   2.6   2.7e-10   2.5e-06     119     173 ..     100     156 ..      77     174 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.058
        DER1 70 sskLEegsfrgrsadyvylllflavlit 97
                +  LE g f+ +++  v  ++++ +   
  EFC39255.1  7 AAVLETGRFNSSTKLIVCTIIVVFLESI 34
                5678888888885544444443333222 PP

  == domain 2  score: 27.6 bits;  conditional E-value: 2.7e-10
        DER1 119 vwskknkdvqvsFfgvlrvkakylPlvllaf.sfllge.svvvsligilvghiyyfl 173
                 + s + ++++ s fg+++v +ky+P++ll++ sfl+   s+v +l+gi++g+i+ +l
  EFC39255.1 100 IASTDTSQTTNSLFGMISVPSKYYPWILLLVtSFLFPSsSFVGHLFGIISGYIFVLL 156
                 567788899999***************986637888888999***********9887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (230 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       596  (0.0332422); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.30s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1493.13
//
Query:       EFC39256.1  [L=261]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-14   54.7   0.0    1.5e-14   54.1   0.0    1.3  1  DEAD      DEAD/DEAH box helicase


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.1   0.0   8.6e-19   1.5e-14      29     149 ..      99     224 ..      76     235 .. 0.94

  Alignments for each domain:
  == domain 1  score: 54.1 bits;  conditional E-value: 8.6e-19
                 HHHHHHHHHHHHHS......TTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEEETTSSHHHHHHHHHTTCSEEEEEHHHHHHHHHCTSSHCTT CS
                 xxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  29 laflipvlqivyet......kgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlliiggvaardqlskldngvdivvgtpgrlddllstgklnlsq 121
                 l+++i++l++++++      +++ +   +++ P reLa  + + l+ + + ++++v+ +++g++ ++  +++  g++++vgt g +  l++++ +++s+
  EFC39256.1  99 LCYSIAILDKLSKNstpsqeNTQLTIEYIVILPVRELALSISSMLNHISQDLSVKVCTCVSGSSLTEMARHI-YGAKVLVGTAGYISYLVNQNLIDFSK 196
                 699********999999988788899**********************************************.************************** PP

                 EEEEEEETHHHHHHTTTHHHHHHHHHHS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD 122 vrflVlDEadrlldqgfsdfinrilnql 149
                 v+++V+D  d  l+ gf+++++ ++ q 
  EFC39256.1 197 VKMIVMDFLDLTLEYGFREDLELLFGQN 224
                 *********************9988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       699  (0.0389871); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.29s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 1855.09
//
Query:       EFC39257.1  [L=347]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.3e-16   57.3  43.5    7.7e-06   25.6   6.9    6.9  9  LRR_8     Leucine rich repeat
    1.1e-14   54.3  37.3    6.6e-05   23.2   0.4    9.2 12  LRR_4     Leucine Rich repeats (2 copies)
    2.2e-10   39.8  25.7      0.096   12.8   0.2    9.4  8  LRR_6     Leucine Rich repeat
    3.6e-06   26.6   8.0    0.00052   19.6   1.5    3.8  4  LRR_9     Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.9   0.0    0.0051        23      10      30 ..      30      50 ..      20      53 .. 0.61
   2 !   11.1   0.4   5.8e-05      0.26      15      53 ..      57      92 ..      54      97 .. 0.88
   3 ?   -1.1   0.1      0.36   1.6e+03      49      59 ..     101     111 ..      97     113 .. 0.66
   4 !   14.4   0.1   5.4e-06     0.024       1      59 [.     138     196 ..     138     198 .. 0.96
   5 !   20.8   1.0   5.3e-08   0.00024       2      61 .]     163     222 ..     162     222 .. 0.96
   6 !   22.2   4.6     2e-08     9e-05       1      61 []     186     246 ..     186     246 .. 0.96
   7 !   25.6   6.9   1.7e-09   7.7e-06       1      61 []     210     268 ..     210     268 .. 0.98
   8 !   23.6   4.0     7e-09   3.2e-05       2      61 .]     235     290 ..     234     290 .. 0.93
   9 ?    2.8   0.1     0.023     1e+02       5      38 ..     299     332 ..     299     346 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0051
                TS--SEE-TTSSTT-TT--EE CS
       LRR_8 10 nNrltslddeaFkglsnLkvL 30
                n++l   +de F g++nLk+L
  EFC39257.1 30 NTYLRYFNDEYFAGFKNLKEL 50
                444556666666666666666 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 5.8e-05
                EE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.E CS
       LRR_8 15 slddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrs 53
                 +d e+ k+l+nL+ L+L+   ++ +s  +++ Lp+L +
  EFC39257.1 57 RIDAEWLKSLHNLELLELTGS-IRNIS--VLETLPKLSK 92
                7999****************9.99998..9999999876 PP

  == domain 3  score: -1.1 bits;  conditional E-value: 0.36
                 -S-.EEE--SS CS
       LRR_8  49 psLrsLdLsgN 59 
                 ++L++L+L +N
  EFC39257.1 101 RHLDELTLFNN 111
                 55666666666 PP

  == domain 4  score: 14.4 bits;  conditional E-value: 5.4e-06
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +nLt+L +s+  +  ++ e+ ++l +L+ L++s   +t   ++ +  L++L sL+++++
  EFC39257.1 138 SNLTTLKISKHIIGMVGAECISKLISLTNLEISFGGITESGARKLCKLTNLHSLTITYD 196
                 69****************************************************99876 PP

  == domain 5  score: 20.8 bits;  conditional E-value: 5.3e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L +s+  +t+ +     +l+nL +L +++ +++    + +++Lp+L++LdL++N +
  EFC39257.1 163 SLTNLEISFGGITESGARKLCKLTNLHSLTITYDTIEGGTSHLIDSLPHLTHLDLTRNYI 222
                 79************************************99******************76 PP

  == domain 6  score: 22.2 bits;  conditional E-value: 2e-08
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +nL+sL ++   +++   +   +l++L++LdL++N +   + + +s L++L+sL L+ Nr+
  EFC39257.1 186 TNLHSLTITYDTIEGGTSHLIDSLPHLTHLDLTRNYIFDNHIRNISKLKNLTSLILDVNRI 246
                 59***********************************999999**************9997 PP

  == domain 7  score: 25.6 bits;  conditional E-value: 1.7e-09
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 p+Lt LdL++N++ + +    ++l+nL++L L  N++++l+   +s L+ L  L LsgN++
  EFC39257.1 210 PHLTHLDLTRNYIFDNHIRNISKLKNLTSLILDVNRISSLD--EISKLETLNCLKLSGNHI 268
                 79**************************************6..****************98 PP

  == domain 8  score: 23.6 bits;  conditional E-value: 7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLtsL+L+ Nr++sld  +  +l+ L+ L+Ls N ++ +    +sg++ Lr L LsgN +
  EFC39257.1 235 NLTSLILDVNRISSLDEIS--KLETLNCLKLSGNHIKDVK--PLSGMKFLRILSLSGNYI 290
                 9**************9865..68****************5..999*************86 PP

  == domain 9  score: 2.8 bits;  conditional E-value: 0.023
                 EEE-TTS--SEE-TTSSTT-TT--EEE--SS--- CS
       LRR_8   5 sLdLsnNrltslddeaFkglsnLkvLdLsnNllt 38 
                 sL L ++++ + + +   + + L +LdL + +lt
  EFC39257.1 299 SLGLASSNIGDEGAKHLASIPTLIELDLEEANLT 332
                 58899999999999999999********998887 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0       0.2   9.1e+02      16      36 ..      12      33 ..       2      39 .. 0.67
   2 !    6.0   0.0    0.0038        17       2      33 ..      20      55 ..      19      65 .. 0.72
   3 !   12.0   0.7     5e-05      0.23       1      43 [.      45      85 ..      45      89 .. 0.84
   4 ?    3.9   2.3     0.018        80       2      28 ..      68      93 ..      67     120 .. 0.67
   5 ?    0.7   0.1      0.18     8e+02      19      32 ..     136     147 ..     127     154 .. 0.64
   6 ?    3.5   0.1     0.023     1e+02       2      31 ..     139     170 ..     138     175 .. 0.72
   7 !    7.9   0.1   0.00095       4.3       2      32 ..     163     195 ..     162     200 .. 0.80
   8 !   13.3   0.9   1.9e-05     0.084      20      44 .]     207     235 ..     197     235 .. 0.86
   9 !   16.6   5.6   1.7e-06    0.0076       1      43 [.     210     253 ..     210     255 .. 0.82
  10 !   12.3   2.3     4e-05      0.18       1      30 [.     234     260 ..     234     262 .. 0.94
  11 !   23.2   0.4   1.5e-08   6.6e-05       3      36 ..     258     290 ..     255     297 .. 0.90
  12 ?    3.2   0.1      0.03   1.3e+02       1      28 [.     319     345 ..     299     347 .] 0.65

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.2
                -S-HHH-TT--EEE-..-S--- CS
       LRR_4 16 iplleklpnLkeLdL.sgNnli 36
                +  l+k  nL+eL +  +N+++
  EFC39257.1 12 VKVLNKYCNLQELIMrMENTYL 33
                5558889999999763345555 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0038
                S--EEE--..SS---.E-S-.HHH-TT--EEE-.-S CS
       LRR_4  2 nLevLdLs..nNqlt.dipl.leklpnLkeLdLsgN 33
                nL++L  +  n+ l+   +  +++++nLkeL + g+
  EFC39257.1 20 NLQELIMRmeNTYLRyFNDEyFAGFKNLKELRIFGM 55
                788888888555688444448889*******99555 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 5e-05
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeLk 43
                +nL++L +++  +  i+   l++l nL+ L L+g   i++++ L+
  EFC39257.1 45 KNLKELRIFG--MERIDAewLKSLHNLELLELTGS--IRNISVLE 85
                69*******9..88888866778*********886..88888764 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.018
                S--EEE--SS---E-S-HHH-TT--EE CS
       LRR_4  2 nLevLdLsnNqltdiplleklpnLkeL 28
                nLe L L +  ++ i+ le lp+L ++
  EFC39257.1 68 NLELLELTG-SIRNISVLETLPKLSKI 93
                889999997.78888888866666554 PP

  == domain 5  score: 0.7 bits;  conditional E-value: 0.18
                 HHH-TT--EEE-.- CS
       LRR_4  19 leklpnLkeLdLsg 32 
                 ++   nL++L +s 
  EFC39257.1 136 FG--SNLTTLKISK 147
                 33..7888888865 PP

  == domain 6  score: 3.5 bits;  conditional E-value: 0.023
                 S--EEE--SS---E-S-...HHH-TT--EEE-. CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLs 31 
                 nL++L +s  ++    +   ++kl +L+ L +s
  EFC39257.1 139 NLTTLKISK-HIIGMVGaecISKLISLTNLEIS 170
                 899999996.67755553654479999999886 PP

  == domain 7  score: 7.9 bits;  conditional E-value: 0.00095
                 S--EEE--.SS---E-S-..HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLs.nNqltdipl..leklpnLkeLdLsg 32 
                 +L++L +s +  +t+ +   l kl+nL++L+++ 
  EFC39257.1 163 SLTNLEISfG-GITESGArkLCKLTNLHSLTITY 195
                 7999999976.9**988866559*******9954 PP

  == domain 8  score: 13.3 bits;  conditional E-value: 1.9e-05
                 HH-TT--EEE-.-S....-----GGGGXX CS
       LRR_4  20 eklpnLkeLdLsgN....nlitdldeLkn 44 
                  +lp+L++LdL++N    n i+++++Lkn
  EFC39257.1 207 DSLPHLTHLDLTRNyifdNHIRNISKLKN 235
                 35*********9999999999***99987 PP

  == domain 9  score: 16.6 bits;  conditional E-value: 1.7e-06
                 SS--EEE--.S....S---E-S-HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4   1 pnLevLdLs.n....NqltdiplleklpnLkeLdLsgNnlitdldeLk 43 
                 p+L++LdL  n    N+++ i+    l+nL++L L + n+i++lde++
  EFC39257.1 210 PHLTHLDLTrNyifdNHIRNISK---LKNLTSLIL-DVNRISSLDEIS 253
                 79*******55666666666666...*******88.988*****9987 PP

  == domain 10  score: 12.3 bits;  conditional E-value: 4e-05
                 SS--EEE--SS---E-S-HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdL 30 
                 +nL++L L  N++++++    + +L++L++
  EFC39257.1 234 KNLTSLILDVNRISSLDE---ISKLETLNC 260
                 79*******99****999...*******98 PP

  == domain 11  score: 23.2 bits;  conditional E-value: 1.5e-08
                 --EEE--SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdiplleklpnLkeLdLsgNnli 36 
                 L  L Ls+N+++d+ +l++++ L+ L+LsgN +i
  EFC39257.1 258 LNCLKLSGNHIKDVKPLSGMKFLRILSLSGN-YI 290
                 66799*************************9.65 PP

  == domain 12  score: 3.2 bits;  conditional E-value: 0.03
                 SS--EEE--SS---E-S-HHH-TT--EE CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeL 28 
                 p L++LdL   +lt+ +    l n k+L
  EFC39257.1 319 PTLIELDLEEANLTEEGIAL-LSNIKTL 345
                 45677777766677654444.5555555 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.0   0.1    0.0067        30       3      24 .]     138     159 ..     137     159 .. 0.93
   2 !    8.9   0.1   0.00038       1.7       4      24 .]     163     183 ..     160     183 .. 0.93
   3 !    9.1   0.3   0.00034       1.5       2      13 ..     209     220 ..     208     227 .. 0.89
   4 ?    1.7   0.3      0.08   3.6e+02       3      16 ..     234     247 ..     232     248 .. 0.87
   5 !    8.1   0.3    0.0007       3.1       4      17 ..     257     270 ..     254     271 .. 0.89
   6 ?    2.2   0.0     0.054   2.4e+02       4      13 ..     279     288 ..     277     290 .. 0.88
   7 !   12.8   0.2   2.2e-05     0.096       7      24 .]     299     316 ..     298     316 .. 0.93
   8 ?    3.2   0.0     0.026   1.2e+02       3      23 ..     319     339 ..     317     340 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0067
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L +s + Ig +Gae+++
  EFC39257.1 138 SNLTTLKISKHIIGMVGAECIS 159
                 69*****************996 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00038
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt L++s+ +I+ +Ga +L+
  EFC39257.1 163 SLTNLEISFGGITESGARKLC 183
                 8******************98 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00034
       LRR_6   2 nthLteLdLsgN 13 
                  +hLt+LdL+ N
  EFC39257.1 209 LPHLTHLDLTRN 220
                 58********99 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.08
       LRR_6   3 thLteLdLsgNdIg 16 
                  +Lt+L L  N I+
  EFC39257.1 234 KNLTSLILDVNRIS 247
                 58*********996 PP

  == domain 5  score: 8.1 bits;  conditional E-value: 0.0007
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +L  L LsgN+I D
  EFC39257.1 257 TLNCLKLSGNHIKD 270
                 89**********99 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.054
       LRR_6   4 hLteLdLsgN 13 
                  L+ L+LsgN
  EFC39257.1 279 FLRILSLSGN 288
                 59*******9 PP

  == domain 7  score: 12.8 bits;  conditional E-value: 2.2e-05
       LRR_6   7 eLdLsgNdIgDeGaeaLa 24 
                 +L L++ +IgDeGa+ La
  EFC39257.1 299 SLGLASSNIGDEGAKHLA 316
                 799*************98 PP

  == domain 8  score: 3.2 bits;  conditional E-value: 0.026
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++L eLdL   +++ eG+  L
  EFC39257.1 319 PTLIELDLEEANLTEEGIALL 339
                 6999*************9877 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.38   1.7e+03      88     121 ..      19      53 ..      11      62 .. 0.69
   2 !    5.8   0.2    0.0019       8.5      82     131 ..      82     128 ..      61     148 .. 0.73
   3 !    8.5   0.5    0.0003       1.3      63     120 ..     185     241 ..     166     246 .. 0.86
   4 !   19.6   1.5   1.2e-07   0.00052      51     132 ..     224     297 ..     216     303 .. 0.85

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.38
       LRR_9  88 Pnleelvltnne..lqeladldPlaslkklellsll 121
                  nl+el++  ++  l+ ++d + +a +k+l+ l ++
  EFC39257.1  19 CNLQELIMRMENtyLRYFND-EYFAGFKNLKELRIF 53 
                 57888887533223777777.888888888887765 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0019
       LRR_9  82 gleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkey 131
                  + e+lP+l+++++   ++++l +   l+ +++l+ +++++n+ ++ +  
  EFC39257.1  82 SVLETLPKLSKILFKRGKFRHLDE---LTLFNNLREVAFISNTPCHYDTN 128
                 46789*********9999988877...77777777777777776655554 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.0003
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsl 120
                 l  l++l +  + i   +  l ++lP+l++l lt n + + +++  + +lk+l++l l
  EFC39257.1 185 LTNLHSLTITYDTIEGGTSHLIDSLPHLTHLDLTRNYIFD-NHIRNISKLKNLTSLIL 241
                 6778899999999999999999**************9988.67899999999999876 PP

  == domain 4  score: 19.6 bits;  conditional E-value: 1.2e-07
       LRR_9  51 dndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyr 132
                 dn ir+   +  lk l +l+l+ nri  + e     l +l++l l++n+++   d++Pl  +k l++lsl  n ++ +++y 
  EFC39257.1 224 DNHIRN---ISKLKNLTSLILDVNRISSLDEI--SKLETLNCLKLSGNHIK---DVKPLSGMKFLRILSLSGNYIMPNTKYG 297
                 677765...556899***********998764..568999********997...689*****************99999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       341  (0.0190195); expected 358.6 (0.02)
Passed bias filter:                      256  (0.0142785); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.24s 00:00:00.78 Elapsed: 00:00:00.44
# Mc/sec: 2394.07
//
Query:       EFC39258.1  [L=416]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        6.4    6.5   6.1        8.6    6.1   5.5    1.5  1  FA_desaturase  Fatty acid desaturase


Domain annotation for each model (and alignments):
>> FA_desaturase  Fatty acid desaturase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   5.5   0.00048       8.6     108     177 ..     209     279 ..     177     288 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.00048
  FA_desaturase 108 wllalvlglwlrrlarrrapsksrrrkwrllawlllllawlglwlalllllglall.lwlvplllllflla 177
                     ++  +++ +l    ++++p++++ +k +++a+ l+++a+l++ +++++ + l +  ++l+ ++++ +l  
     EFC39258.1 209 IVMRWYGMATLINQNQQGKPNNYSIKKVYIIAVILFFIAVLFVCFVTVAIPLLIGDqYFLYTYVAISWLSE 279
                    22222333367777777777777777788888888888666666666666666666*********999765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1673  (0.0933125); expected 358.6 (0.02)
Passed bias filter:                      671  (0.0374254); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2522.01
//
Query:       EFC39259.1  [L=1243]
Description: FH2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-50  172.5  24.5    4.6e-50  170.8  24.5    2.0  1  FH2       Formin Homology 2 Domain
    0.00022   21.6  21.0      0.002   18.5   3.9    4.9  3  LRR_4     Leucine Rich repeats (2 copies)
    0.00059   19.4   2.6    0.00059   19.4   2.6    4.7  5  LRR_9     Leucine-rich repeat
     0.0042   16.8   3.6     0.0042   16.8   3.6    4.0  4  LRR_8     Leucine rich repeat
  ------ inclusion threshold ------
       0.88   10.0   4.4        2.8    8.4   0.2    3.0  2  Ago_N_1   Fungal Argonaute N-terminal domain
        2.2    8.1   7.4       0.66    9.8   1.0    3.3  3  Tma16     Translation machinery-associated protein 16


Domain annotation for each model (and alignments):
>> FH2  Formin Homology 2 Domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  170.8  24.5   1.5e-53   4.6e-50       4     372 .]     476     861 ..     473     882 .. 0.89

  Alignments for each domain:
  == domain 1  score: 170.8 bits;  conditional E-value: 1.5e-53
                 X---SS-B------EESSGGCTTS.CCCCTCCHHHHC...TSHHHHHHHHTBSC--HCCH......HCSCCTTCCESSS-HHHHHHHHHHHHHH..TS- CS
         FH2   4 kikpkkkLkplhWdkvkpsqdrst.vWdklkeesfek...eldlseleelFsakekkkkkkksekskkskkkkkkvklLdpkrsqniaIlLkkl..klt 96 
                 ++k   k+k +hW+ +++++d+ + vW   +e+++ +   +  +++l++lFsak++ + + k  k++k++  ++ ++++d+ ++ n++Il   l    +
  EFC39259.1 476 VKKEVSKTKNIHWKPIRNTKDKVKsVWVLEDEDEEMDeeqKAIFEKLDNLFSAKKTSSPSTK-VKNPKKAIDDELNTIIDSSLARNLEILVNGLfkYCE 573
                 5566789***********999988999766666555455699************99988888.999***************************997789 PP

                 HHHHHHHHHTTTTCCCTHHHHHHHHHHCGGHHHHHHHHCTCTS.GTTB-HHHHHHHHHTTSTTHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHHH CS
         FH2  97 aeeiveaileldeealdlellenLlkmaPtkeelkklkeykge.vseLseaeqFllelvkiprlekRleallfkstfeeeveelkrslealeaaseeLk 194
                  + + +ai  ++ e l++++++ L++++P  ee+ k ke  ++  ++L +   +++ l++i+ l +Rl+++  ++tf++  + ++  ++a   +++ L+
  EFC39259.1 574 LKTLLDAINTMNVESLTIDQIKGLSQFVPATEEIVKKKEVVEKyFDNLRPSLLWTWKLAEISILPTRLQLMQHMKTFDT--TRISDTITAKLNTVDNLQ 670
                 9************************************988888688998888*************************87..5788888888888899** PP

                 H-HHHHHHHHHHHHHHHHHSTCSTT.CS-SEE-GGGGGGCCCSB-S.TTTSBHHHHHHHHHHTTSGGGGGHHHHTTTHHHCC....TS-HHHHHHHHHH CS
         FH2 195 nskkfkklLeliLalGNymNdgtrr.gqAkGFkLssLlkLsdvKst.dnkttLLHylvkiireklpevldfsseLknvkkaa....kvnleslekevkk 287
                 nsk+f klL+++L++GNymN g+++ ++A+GF L++L kLsd+Ks+ + kttL+H+l+++++++ +e+ +f+ eL++   ++    +++l+ +++++k+
  EFC39259.1 671 NSKSFVKLLHMLLKVGNYMNRGKAQlEEAQGFHLNILPKLSDTKSSiNPKTTLVHFLAETLKNEKSELFNFEVELESYGVCSsdifNIKLDIIQQDLKE 769
                 ****************************************************************************98655522227999999999999 PP

                 HHHHHHHHHHHHHHCCT..TSSTT-THHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT--TT.....CCHHHHHHHHHHHHHHHHH CS
         FH2 288 lekglkklekelessek..keepsdkflevlkeflkeaeeklkkleeelkeakelvkelveYfgedkk.....evspeeffkilreFlkefk 372
                 +++  + ++ +  + ++  k+e+++k+ +  ++fl++++e+++++e++ +++++ +k ++++f  +++       + + +  i+++F++ fk
  EFC39259.1 770 IQDVRELFQSKKPDIDTikKKEKNHKIEANFSSFLSKCNESVSQVESLFEKLNNSYKMACDFFHFNPTedealSLPGDPLLIIVKDFINHFK 861
                 998888777766666667779******************************************55554333367777778888888888775 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   3.4      0.19   5.7e+02       1      39 [.     246     284 ..     246     289 .. 0.72
   2 !   18.5   3.9   6.7e-07     0.002       2      39 ..     296     334 ..     295     339 .. 0.89
   3 !    9.0   0.2   0.00063       1.9       2      36 ..     345     381 ..     344     386 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.19
                 SS--EEE--SS---E-S-HH.H-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdiplle.klpnLkeLdLsgNnlitdl 39 
                 +nL++  L  +++ +i l++ + pnL  L L +N  i+++
  EFC39259.1 246 KNLKNFKLTKTNVDKILLPGvNVPNLADLCLQHN-SISNI 284
                 5888888888888888887767999999988666.55555 PP

  == domain 2  score: 18.5 bits;  conditional E-value: 6.7e-07
                 S--EEE--SS---E-S-HH..H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitdl 39 
                 nL+vLdLs N l  ++ ++  klpnL+  d+ +Nn+++++
  EFC39259.1 296 NLTVLDLSFNLLENLDYFSvvKLPNLEIADV-SNNYLENV 334
                 9****************99999*********.66699876 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00063
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 +L+ ++L++N++ +++    l  ++nL+ L+L +N ++
  EFC39259.1 345 KLKQVYLHGNNILEWNQiypLTYFDNLEALTLVEN-PL 381
                 7999**********999775557*********999.55 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.4      0.16   4.8e+02      20      57 ..      71     105 ..      57     187 .. 0.72
   2 !    5.6   0.8    0.0033       9.8      63     134 ..     218     290 ..     204     301 .. 0.81
   3 !   19.4   2.6     2e-07   0.00059      46     135 ..     299     392 ..     293     400 .. 0.82
   4 ?    2.3   0.1     0.034     1e+02      62     134 ..     577     650 ..     569     666 .. 0.79
   5 ?   -2.1   0.0       0.8   2.4e+03      43      70 ..     649     676 ..     641     710 .. 0.65

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.16
       LRR_9  20 rereldlrgykipvienlGatldqfdtidlsdndirkl 57 
                 ++re++       +i+n+   ++ +dti++++nd+  +
  EFC39259.1  71 QKREANQNKILKWIIDNI---VNSYDTIQVTNNDLEII 105
                 566666665555677777...46789999999998754 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0033
       LRR_9  63 lkrlktlllnnnrivriaegl...eevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrly 134
                 l+  + l+++n  i  i++ +   ++   nl+++ lt+ +++++  l P +++++l  l+l +n+++n k  ++ 
  EFC39259.1 218 LEHTEGLSIENCEIAEINNSIfkeNREWKNLKNFKLTKTNVDKI--LLPGVNVPNLADLCLQHNSISNIKFSKNN 290
                 6666789999999999999984334467899**********998..67******************998765555 PP

  == domain 3  score: 19.4 bits;  conditional E-value: 2e-07
       LRR_9  46 tidlsdndirkldgfPl..lkrlktlllnnnrivriaegleev.lPnleelvltnnelqeladldPlaslkklellsllknpvtnkk.eyrlyv 135
                  +dls n + +ld f    l  l++  ++nn + ++   l+ +   +l+++ l +n++ e +++ Pl+ + +le l+l++np+ +++ +y + +
  EFC39259.1 299 VLDLSFNLLENLDYFSVvkLPNLEIADVSNNYLENVIGLLQACdKDKLKQVYLHGNNILEWNQIYPLTYFDNLEALTLVENPLQKEEpDYLKVI 392
                 57999999999**9987224589999999**9999987777652578************************************98751555444 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.034
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqelad.ldP.laslkklellsllknpvtnkkeyrly 134
                 ll  ++t+ +++  i +i +gl++++P  ee+v  ++ +++  d l P l    kl  +s+l + +   ++ +++
  EFC39259.1 577 LLDAINTMNVESLTIDQI-KGLSQFVPATEEIVKKKEVVEKYFDnLRPsLLWTWKLAEISILPTRLQLMQHMKTF 650
                 566777888888888888.59***************999886543787566778999999998888777776665 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 0.8
       LRR_9  43 qfdtidlsdndirkldgfPllkrlktll 70 
                  fdt  +sd    kl+ +  l+  k+++
  EFC39259.1 649 TFDTTRISDTITAKLNTVDNLQNSKSFV 676
                 5777777877777776666666555543 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.8     0.091   2.7e+02       6      61 .]     224     281 ..     220     281 .. 0.74
   2 ?    1.7   1.3     0.071   2.1e+02      23      40 ..     267     284 ..     246     292 .. 0.79
   3 !   16.8   3.6   1.4e-06    0.0042       2      61 .]     296     356 ..     295     356 .. 0.87
   4 ?    2.1   0.1     0.055   1.6e+02       2      39 ..     345     383 ..     344     390 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.091
                 EE-TTS--SEE-TTSSTT...-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   6 LdLsnNrltslddeaFkg...lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L++ n  + +++ + Fk    ++nLk ++L+  + + +     ++ p+L  L L++N +
  EFC39259.1 224 LSIENCEIAEINNSIFKEnreWKNLKNFKLTKTNVDKI-LLPGVNVPNLADLCLQHNSI 281
                 67778888888888887544578888888888888886.45667888888888888875 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.071
                 T-TT--EEE--SS---GG CS
       LRR_8  23 glsnLkvLdLsnNllttl 40 
                 +++nL  L L +N+++ +
  EFC39259.1 267 NVPNLADLCLQHNSISNI 284
                 578999999999999887 PP

  == domain 3  score: 16.8 bits;  conditional E-value: 1.4e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 nLt+LdLs+N l++ld  +  +l+nL++ d snN l+  +      +  +L++ +L gN++
  EFC39259.1 296 NLTVLDLSFNLLENLDYFSVVKLPNLEIADVSNNYLENvIGLLQACDKDKLKQVYLHGNNI 356
                 8*********************************999845555555667899999999987 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.055
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt 39 
                 +L+ ++L+ N++ + ++    + + nL+ L L +N l+ 
  EFC39259.1 345 KLKQVYLHGNNILEWNQIYPLTyFDNLEALTLVENPLQK 383
                 688899999998888888877778899999888887765 PP

>> Ago_N_1  Fungal Argonaute N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.5      0.15   4.6e+02      14      67 ..      77     134 ..      67     155 .. 0.62
   2 ?    8.4   0.2   0.00092       2.8       8      71 ..     508     573 ..     506     582 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.15
                 -TT----HHHHHHHHHHHHHHHHS....TTTS----CCHHHHHHHH-HHHHCCCTT-E CS
     Ago_N_1  14 nekeqytlldWilecykqaeaark....aktkgkpsakdlnlfveknkdikdllkGlk 67 
                 ++k    ++d i++ y++++++++      +k k+ + ++++f +k +  ++l+   k
  EFC39259.1  77 QNKILKWIIDNIVNSYDTIQVTNNdleiIMNKFKTIVSSIEIFYKKVRRFEHLTESEK 134
                 3333333455555667777765555655444555566677777777777777766555 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00092
                 SHHHHH-TT----HHHHHHHHHHHHHHHHSTTTS----CCHHHHHHHH-..HHHHCCCTT-EEE-T CS
     Ago_N_1   8 dpkfkenekeqytlldWilecykqaeaarkaktkgkpsakdlnlfvekn..kdikdllkGlkvyrp 71 
                 d +++e++k+ +  ld ++   k+++ + k k+ +k+  ++ln++++    ++++ l+ Gl  y++
  EFC39259.1 508 DEEMDEEQKAIFEKLDNLFSAKKTSSPSTKVKNPKKAIDDELNTIIDSSlaRNLEILVNGLFKYCE 573
                 567889999*****************999999999999********9753379999****988875 PP

>> Tma16  Translation machinery-associated protein 16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.2      0.55   1.6e+03      32      69 ..      70     109 ..      53     115 .. 0.77
   2 ?   -1.2   0.0      0.58   1.7e+03      57      83 ..     676     702 ..     645     740 .. 0.63
   3 ?    9.8   1.0   0.00022      0.66      25     102 ..     811     889 ..     788     895 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.55
       Tma16  32 rakkkssllervkffqealde..ekkplsleelkelieky 69 
                 ++k++ ++ +++k++ +++ +  ++ ++++++l+ + +k+
  EFC39259.1  70 TQKREANQNKILKWIIDNIVNsyDTIQVTNNDLEIIMNKF 109
                 56778889999*****998887777778888877776665 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.58
       Tma16  57 lsleelkeliekylkRndeeleelkse 83 
                 ++l ++   + +y++R + +lee +  
  EFC39259.1 676 VKLLHMLLKVGNYMNRGKAQLEEAQGF 702
                 444455555558888888888887754 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00022
       Tma16  25 lakkkkerakkkssllervkffqealde.ekkplsleelkeliekylkRndeeleelkserrkgrpkskreelleekke 102
                 ++++++  +k ++s+   + ff+ +  e e  +l  + l  +++++++ +++  + l +e rk++++ kr   l+  ++
  EFC39259.1 811 VSQVESLFEKLNNSYKMACDFFHFNPTEdEALSLPGDPLLIIVKDFINHFKKAKDDLDKEERKNQQALKRTLTLKRIQS 889
                 5566666777788888888888877666355667778899999***************************999987654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1878  (0.104747); expected 358.6 (0.02)
Passed bias filter:                      396  (0.0220871); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.04u 0.35s 00:00:01.39 Elapsed: 00:00:00.57
# Mc/sec: 6525.82
//
Query:       EFC39260.1  [L=359]
Description: enoyl-CoA hydratase/isomerase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-44  151.8   0.0      3e-44  151.2   0.0    1.2  1  ECH_1     Enoyl-CoA hydratase/isomerase
    5.9e-14   52.3   0.0    3.5e-13   49.7   0.0    2.0  2  ECH_2     Enoyl-CoA hydratase/isomerase
  ------ inclusion threshold ------
        8.1    6.7   9.0        1.1    9.5   2.1    2.7  3  Toxin_3   Scorpion toxin-like domain


Domain annotation for each model (and alignments):
>> ECH_1  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  151.2   0.0   5.1e-48     3e-44       5     244 ..     113     356 ..     110     358 .. 0.89

  Alignments for each domain:
  == domain 1  score: 151.2 bits;  conditional E-value: 5.1e-48
                 TEEEEEE--CGCTTEE-HHHHHHHHHHHHHHHHSTTECEEEEEEBTSEEEEEB-HHHHHHHHC.HHHHHHHCCHHHHHHHHHHSSSEEEEEE-.SEEET CS
       ECH_1   5 gvaviklnrPeavNalsaelltEliqalekleddksvravvLtGgdkaFaaGadlkemaeeek.akqallkeevlelwtklytvpkpviaavn.Gaaig 101
                 ++  ik++rPe++Na++  + +El qa+ ++e+d ++r+++L G++  F+ Gadlk++ e++  + + ++k +   l    +++ kpviaa+  G++++
  EFC39260.1 113 TIQIIKIQRPEVKNAIDRRTADELYQAFFDFEKDVNARVAILYGSETDFCVGADLKAVSEGNLnQVEPVTKTAKGPLGPTRMSLSKPVIAAIGgGYCVA 211
                 7899*********************************************************9955566777777888889999*********736**** PP

                 HHHHHHHHSSEEEEETTTEEE-GGGGGTS--CTTCHHHHHHHHHHHHHHHHHHHT-EEEHHHHHHCTSSSEEESG.GGHHHHHHHHHHHHHHSCHHHHH CS
       ECH_1 102 GGlelalacDiviaadnasfglnelklGlipgaggtqilarkvGkskAeeilllgkkisaqealkvGlvdkvvpe.eqlleealelaeklaekspaalr 199
                 GGlela  cD++++  n+ fg n  ++G+    gg+ +l+  +G s+A+ ++l+g++i ++ea k+Gl+++++++ e++l+ a++la++l   +++ +r
  EFC39260.1 212 GGLELACWCDLRVCKTNSIFGVNCRRYGVPLIDGGSIRLPTLIGLSRAMDLILTGREIDGKEAHKIGLINRIISKdENVLDCAVKLANQLCVFPQLCMR 310
                 ****************************99889*****************************************9889*************99999999 PP

                 HHH.HHHHHHHH.HHHHHHHHHHHHHHHHHCTSHHHHHHHHHHHTCS CS
       ECH_1 200 qlk.ealnakle.dalaeqleaeaklfestfskddikeGlqaflEkr 244
                   k +al+a+++ +  +e+l+ e +l     +  +  +G +af+ ++
  EFC39260.1 311 NDKtSALEAAYSgKSMKEKLQREYELGLTALNI-ETVKGAKAFVNRK 356
                 865268999999877777777777766555555.3357888888765 PP

>> ECH_2  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.7   0.0   5.9e-17   3.5e-13       2     176 ..     115     288 ..     114     333 .. 0.88
   2 ?    0.2   0.0      0.07   4.2e+02     272     311 ..     318     356 ..     312     358 .. 0.77

  Alignments for each domain:
  == domain 1  score: 49.7 bits;  conditional E-value: 5.9e-17
                 EEEEE--GGGTT-B-HHHHHHHHHHHHHHCC-TT-SEEEEEESSSSECE--B--HHHHHHHHCS-THHHHHHHHHHHHHHHHHC-SS-EEEEE.-BEEE CS
       ECH_2   2 gvitLnrpkalNaLslemvralkealkewekddevklvvlkgagekafCAGgDvralyeaakegkkeeeeffreeYklnyliatypkpvvalm.dGivm 99 
                 ++i+++rp+  Na++   +++l +a+ ++ekd ++++ +l g +e  fC G D++a+ e + ++ +      +++  l  +  +++kpv+a +  G+++
  EFC39260.1 115 QIIKIQRPEVKNAIDRRTADELYQAFFDFEKDVNARVAILYG-SETDFCVGADLKAVSEGNLNQVEP--VTKTAKGPLGPTRMSLSKPVIAAIgGGYCV 210
                 6899**************************************.569****************98655..35567778999999*******8652689** PP

                 THHHHHHTTSSEEEE-TT-EEE--GGGGT----TTHHHHHHCSST.THHHHHHHH---B-HHHHHHTTS--EE--GGG CS
       ECH_2 100 GgGvGlsvhgsfrvvtertvfAmPEtaIGlfPDvGgsyfLsrlpg.elGlylalTGarlkgadalaaglathyvpsek 176
                  gG+ l++ + +rv   +++f +   + G+    Ggs  L+ l g + ++ l lTG++++g++a ++gl + ++++++
  EFC39260.1 211 AGGLELACWCDLRVCKTNSIFGVNCRRYGVPLIDGGSIRLPTLIGlSRAMDLILTGREIDGKEAHKIGLINRIISKDE 288
                 *****************************98888*********88799***********************9998764 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.07
                 HHHTTT--HHHHHHHHHHHHHHHHHHSSHHHHHHHHTTS- CS
       ECH_2 272 rrgrklsslaevlrmElrlalrllaekDfveGvrallvdk 311
                 + + + +s++e l++E++l l++l + + v+G +a +  k
  EFC39260.1 318 EAAYSGKSMKEKLQREYELGLTAL-NIETVKGAKAFVNRK 356
                 4555556789**********9999.888889988876555 PP

>> Toxin_3  Scorpion toxin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1      0.69   4.1e+03      24      37 ..      24      37 ..      23      43 .. 0.77
   2 ?    9.5   2.1   0.00018       1.1      33      49 ..     206     221 ..     204     222 .. 0.88
   3 ?   -0.1   0.1      0.19   1.1e+03      14      28 ..     292     310 ..     282     327 .. 0.56

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.69
                HHHHHTT-SEEEEE CS
     Toxin_3 24 klCkkngAksGyCq 37
                ++C +ng +s +  
  EFC39260.1 24 NECSSNGSSSSSSA 37
                58999999988765 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00018
                 EEEEEEEETTCCEEEEE CS
     Toxin_3  33 sGyCqwagkyglaCwCk 49 
                 +GyC  ag+ +laCwC+
  EFC39260.1 206 GGYCV-AGGLELACWCD 221
                 7***6.67********7 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.19
                 B-SST..HHHHH..HHHHH CS
     Toxin_3  14 sCapr..nsyCd..klCkk 28 
                  Ca +  n++C   +lC  
  EFC39260.1 292 DCAVKlaNQLCVfpQLCMR 310
                 5555555555522233433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (359 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.37s 00:00:01.06 Elapsed: 00:00:00.59
# Mc/sec: 1838.28
//
Query:       EFC39261.1  [L=522]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      9e-50  169.5   0.0    1.4e-49  168.8   0.0    1.3  1  Pkinase       Protein kinase domain
    2.8e-34  118.6   0.0    4.2e-34  118.0   0.0    1.2  1  Pkinase_Tyr   Protein tyrosine kinase
  ------ inclusion threshold ------
      0.071   12.2   0.1       0.13   11.3   0.1    1.4  1  Seadorna_VP7  Seadornavirus VP7
       0.47   10.9   6.7        0.2   12.1   2.3    2.2  2  PBP1_TM       Transmembrane domain of transglycosylase PBP1 a


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  168.8   0.0   3.2e-53   1.4e-49      56     264 .]       2     203 ..       1     203 [. 0.92

  Alignments for each domain:
  == domain 1  score: 168.8 bits;  conditional E-value: 3.2e-53
                 SCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS. CS
     Pkinase  56 khpnivrlyevfeekdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk. 153
                 ++++iv++++++   ++l++v+e++ gg++adll+  g+++e+++  i++++l++leylH+++ +HrD+K +NiLi e+ge+K++DFG++  l+++   
  EFC39261.1   2 DSEHIVKIFGSYVVRQSLWIVMELLVGGSVADLLK-PGIIDEQHIAVILRETLKALEYLHNEHKMHRDMKAANILIGENGEVKLADFGVVGVLSNGGAt 99 
                 689*******************************7.69*********************************************************9988 PP

                 ....BCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SS CS
     Pkinase 154 ....ltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkd 248
                       + vgt++++APEv+k+++ ++k+D+WslG++ +e+  g pp+s+            +  +i+ i  +++  + e++++s+ +k++++ +l+k+
  EFC39261.1 100 deqkRYTLVGTPYWMAPEVIKQEGSDQKADIWSLGITAIEMAKGAPPYSHMAP---------N-YAIFLIP-KNEPPSLEDTKFSKPFKEFITCCLQKN 187
                 9999999******************************************3222.........2.4455554.447778888999*************** PP

                 GCCSTTHHHHHTSGGG CS
     Pkinase 249 pkkRltaeellqhpyl 264
                 p++Rl a+ell+ +++
  EFC39261.1 188 PQDRLPASELLKLKFI 203
                 ***********98875 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.0   0.0   9.3e-38   4.2e-34      59     256 ..       2     198 ..       1     200 [. 0.91

  Alignments for each domain:
  == domain 1  score: 118.0 bits;  conditional E-value: 9.3e-38
                  -BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTS CS
  Pkinase_Tyr  59 khpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekd 156
                  + ++ivk+ g ++ +++l+iv+e++ gG++ + L+      ++ +++  +  +  k++eyL++++ +Hrd+ a N+L+ en  vk++DfG+   +++ 
   EFC39261.1   2 DSEHIVKIFGSYVVRQSLWIVMELLVGGSVADLLKPG---IIDEQHIAVILRETLKALEYLHNEHKMHRDMKAANILIGENGEVKLADFGVVGVLSNG 96 
                  579*******************************987...99***************************************************99777 PP

                  SEE..EETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS-- CS
  Pkinase_Tyr 157 dey..vkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEiftlgespypglkneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRpt 251
                    +  +k+ +      WmapE++k++   +k+D+Ws G++ +E+++ g+ py+++ ++ ++  + k++    + +k ++ ++e+++ c++++p++R  
   EFC39261.1  97 GATdeQKRYTLVGTPYWMAPEVIKQEGSDQKADIWSLGITAIEMAK-GAPPYSHMAPNYAIFLIpKNEPPSLEDTKFSKPFKEFITCCLQKNPQDRLP 193
                  6663345555566789****************************99.********888888888677778888999********************98 PP

                  HHHHH CS
  Pkinase_Tyr 252 fselv 256
                   sel+
   EFC39261.1 194 ASELL 198
                  88876 PP

>> Seadorna_VP7  Seadornavirus VP7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.1     3e-05      0.13     149     187 ..      51      87 ..      38      95 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3e-05
  Seadorna_VP7 149 aglkdLmdfhsestnllhGDcnpenlmcDknGylklvDP 187
                     lk+L+ +h  +++ +h D++  n++  +nG +kl D 
    EFC39261.1  51 ETLKALEYLH--NEHKMHRDMKAANILIGENGEVKLADF 87 
                   469*******..67789*******************996 PP

>> PBP1_TM  Transmembrane domain of transglycosylase PBP1 at N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   2.3   4.4e-05       0.2      16      62 ..     225     268 ..     216     273 .. 0.67
   2 ?   -0.1   0.1      0.27   1.2e+03      29      54 ..     338     361 ..     327     377 .. 0.50

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 4.4e-05
     PBP1_TM  16 akakparkkasrrrrrdddyddeyddeedDdddddeeeevprkgkkk 62 
                 +++kp+   a++rr  d d   e d + dD  d+de+++ ++k k++
  EFC39261.1 225 SRKKPPNFGATKRRNIDSD--TESDTSLDDISDEDESQHTTKK-KNG 268
                 3445555556665555555..5558999999999999999999.433 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.27
     PBP1_TM  29 rrrdddyddeyddeedDdddddeeee 54 
                 rr++ + +d ++  + Dd  + ++++
  EFC39261.1 338 RREQSQSQDSIEFVKSDD--EYDSST 361
                 333333333333333332..333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1105  (0.061632); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.50
# Mc/sec: 3127.89
//
Query:       EFC39262.1  [L=338]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.7e-78  261.3   0.0    1.1e-77  261.2   0.0    1.0  1  Aldo_ket_red  Aldo/keto reductase family
  ------ inclusion threshold ------
       0.06   12.5   0.0      0.087   12.0   0.0    1.2  1  HpuA          Haemoglobin-haptoglobin utilisation, porphyrin 


Domain annotation for each model (and alignments):
>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  261.2   0.0   1.2e-81   1.1e-77       2     290 ..      16     323 ..      15     327 .. 0.95

  Alignments for each domain:
  == domain 1  score: 261.2 bits;  conditional E-value: 1.2e-81
                   EEEE-SSS-ST.....TS-HHHHHHHHHHHHHTT--EEE--TT-TTTHHHHHHHHHHHH-TTTGGG-EEEEEE...............--SSSTTSS CS
  Aldo_ket_red   2 lglGtwqlgsk....eeiskeealellrraleaGinffDtAevYgkgqseellGealkksrkkreeviiatKv...............dlrdaeiks 79 
                   l+lG +++gs     ++ ++ee+l++l++a + GinffDtA++Y +g+se++lG+++k+ + +ree+++atKv               ++  +++  
    EFC39262.1  16 LCLGCMSFGSSkwipWVLEEEESLRILKKAWDLGINFFDTADMYSNGESERILGKFIKEFNIPREEIVVATKVcgpldhsgeqklimvGNQGKPNTM 112
                   9***************************************************************************************9******** PP

                   SS-HHHHHHHHHHHHHHHT-S-EEEEEE-S--TTS-.HHHHHHHHHHHHHTTSEEEEEEES--HHHHHHH....HHTTT--EEEEE-B-BTT-HHHH CS
  Aldo_ket_red  80 glskeniresleeslkrLgtdyvDllllHrpdpslpsieevldaleelvkeGkiraiGvSnfsveqleka....kkkkkvkivavqveynllrelee 172
                   gls+++i++++++sl+rLg+dy+Dl+ +Hr+d ++p iee+++al++lvk+Gk+r+iG S   ++q  ka    +kk+ +k+++ q+ ynl  ++ee
    EFC39262.1 113 GLSRKHIMHAVDDSLQRLGLDYIDLYIVHRWDEQTP-IEETMEALHDLVKSGKVRYIGASTMFAWQFAKAqhyaEKKGLTKFISMQNLYNLIYREEE 208
                   ************************************.***********************98888888888999*********************** PP

                   TTHHHHHHHTT-EEEEBSTTGGGTTGTTTSS---SSSCCC-------....TS-HHHHHHHHHHHHHHHHTT--HHHHHHHHHTTSTT-SEEEE--S CS
  Aldo_ket_red 173 egllelckkkgvpliaysplggGlltgkyqseedkedkeprkdlkrd....ertsknldaaeelselakehgvslaqlalryalsqpavgivipgas 265
                   +++ +lc ++gv l +++pl++G+l +         d+ +++d  ++    + t++  ++++++se+ak+++vs+aq+al+++ls+p+v+++++ga+
    EFC39262.1 209 REMNPLCVDQGVSLTPWGPLSNGMLARAH-------DFRQNSDIVQTifkgNLTEGDKETLRKVSEIAKKRNVSPAQIALAWLLSKPGVVSPVIGAT 298
                   **************************544.......44445555555667789******************************************** PP

                   SHHHHHHHHGGGG----HHHHHHHH CS
  Aldo_ket_red 266 nieqlednldalelklseeevaeld 290
                   ++  +e n++ale++l+eee + l+
    EFC39262.1 299 KAVNVELNVQALEIQLTEEEKKILE 323
                   *******************988876 PP

>> HpuA  Haemoglobin-haptoglobin utilisation, porphyrin transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   9.7e-06     0.087     231     306 ..      44     119 ..      39     121 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 9.7e-06
        HpuA 231 dvgidgldfsgtae..sdgktgklegkffgkfnsyrdsevsiggkvtfdddksldtvfggveyekdrnettdtsldhl 306
                  +   g++f  ta+  s+g + ++ gkf+ +fn     e+ +  kv    d+s +  +  v ++ ++n t  +s +h+
  EFC39262.1  44 KAWDLGINFFDTADmySNGESERILGKFIKEFNIP-REEIVVATKVCGPLDHSGEQKLIMVGNQGKPN-TMGLSRKHI 119
                 55556999*99997669****************98.67999***************************.988888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.57
# Mc/sec: 1785.29
//
Query:       EFC39263.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       420  (0.0234257); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.27s 00:00:00.73 Elapsed: 00:00:00.45
# Mc/sec: 1359.52
//
Query:       EFC39264.1  [L=659]
Description: prolyl 4-hydroxylase alpha subunit family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      4e-14   53.3   0.1      1e-13   52.0   0.0    1.8  2  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
      2e-06   27.2   0.7      5e-05   22.6   0.0    2.8  3  Pox_C4_C10      Poxvirus C4/C10 protein
    9.6e-05   22.2   0.3    0.00022   21.1   0.3    1.7  1  F-box-like      F-box-like
    0.00014   22.3   0.0    0.00051   20.5   0.0    2.0  1  2OG-FeII_Oxy    2OG-Fe(II) oxygenase superfamily
     0.0013   19.3   0.0     0.0031   18.1   0.0    1.6  1  2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.0   0.0   2.9e-17     1e-13       2      91 ..     148     242 ..     147     247 .. 0.90
   2 ?   -3.7   0.0         5   1.8e+04      26      40 ..     462     477 ..     446     487 .. 0.69

  Alignments for each domain:
  == domain 1  score: 52.0 bits;  conditional E-value: 2.9e-17
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--EEE....................---TT-EEEEE-..B-TEEE--B.-SS CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekeseeGGelelyekdk..........eavkikpkkgrlvlFesdellpHevlpvtkgg 86 
                      +++y++g+++k H+D   +++++++ ++t+l+yLn  ++++GGe ++y++ +            +++kp  g+l+lF+ d    He++pvtkg 
      EFC39264.1 148 RLSKYEPGEYFKIHTDGQFRRSEHERSIYTLLIYLN--QDFKGGETRFYNDPTktdsdfeeysLLHTLKPSLGQLALFNQDFY--HEGCPVTKG- 237
                     6899************8777777799*********8..78********999999*****9999899999***********877..******886. PP

                     -EEEE CS
  2OG-FeII_Oxy_3  87 eRlsl 91 
                     ++++l
      EFC39264.1 238 TKYIL 242
                     **997 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 5
                     -.EEEEEEEEE..... CS
  2OG-FeII_Oxy_3  26 gqrrltvllyLne.ke 40 
                     g+++ +v+ yLn+ ++
      EFC39264.1 462 GSHQGSVFDYLNDpDD 477
                     5677888889987433 PP

>> Pox_C4_C10  Poxvirus C4/C10 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   1.4e-08     5e-05      50     122 ..     107     200 ..      62     253 .. 0.78
   2 ?    1.5   0.0     0.035   1.2e+02     220     250 ..     400     432 ..     396     436 .. 0.79
   3 ?   -1.7   0.1      0.34   1.2e+03     211     247 ..     553     593 ..     549     632 .. 0.63

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 1.4e-08
  Pox_C4_C10  50 knliydqlknvvs....................evevenkvtlvkyekgdyfkrtrn.lstklskntveyylvlyLekpeeGGetkiyikptgs 122
                  +li+++lk+ ++                       +++ + l kye+g+yfk +++ +  +  ++   y+l++yL++  +GGet++y +pt+ 
  EFC39264.1 107 AKLIFERLKETIDldaigklitpygldsrgewkACGINEMMRLSKYEPGEYFKIHTDgQFRRSEHERSIYTLLIYLNQDFKGGETRFYNDPTKT 200
                 455666666666666666666677777777776778999999***************7777777788889******************777653 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.035
  Pox_C4_C10 220 ivrkkkevyksFadlcvdkife..ekelaelen 250
                  vr+++  ++sF+++c+d   e  +++l+++e+
  EFC39264.1 400 HVRVRNFTEHSFKAICIDFTSEmaTYGLFNVET 432
                 5778888899********999977777777765 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.34
  Pox_C4_C10 211 CllvnenqkivrkkkevyksFa.dlcvdkife...ekelae 247
                 C+  ++  +i++ k   y+sF+ d c+ +  e   +k l +
  EFC39264.1 553 CVVIEKDVHITISKVANYQSFDgDSCIVNSLEkelKKSLNQ 593
                 55555555555555555677754666666665333333333 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.3     6e-08   0.00022       4      47 ..     334     377 ..     331     378 .. 0.93

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 6e-08
  F-box-like   4 LPdEiLlqIFsyLppsdLlr.lalVCrrWrrvaldtplLWrrlvl 47 
                 LP+Ei+ ++Fs+L+ s++++ +    r+ +++a+++  +W+ ++ 
  EFC39264.1 334 LPEEIIFTVFSFLKESEICSiVLPLNRYLNQLARSP-IIWKSVYQ 377
                 9*******************779**********987.*****996 PP

>> 2OG-FeII_Oxy  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.0   1.4e-07   0.00051       2      94 ..     144     241 ..     143     250 .. 0.68

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.4e-07
                   --EEEEEEE-S-......-----..---EEEEEESSSEEEEEEE-TT---EE.EE....TE.EEE----TTEEEEEE-HHHHHHTTS-S----EEE- CS
  2OG-FeII_Oxy   2 eellvlnyypph......pdpev..ilglgahtdaslltillqddvgglevf.kd....gk.wlrvppvdnslivniGdallflsngryksvlHrVl 84 
                   +e+++l +y+p       +  +       ++ + ++ll++l+qd +gg++ f +d    ++ ++++    ++l++  G+   ++ n   +++ H+++
    EFC39264.1 144 NEMMRLSKYEPGeyfkihT--DGqfRRSEHERSIYTLLIYLNQDFKGGETRFyNDptktDSdFEEYS-LLHTLKPSLGQL-ALF-N---QDFYHEGC 232
                   5777888877776665322..2233333478889999************887444666544466665.458********6.443.3...36****** PP

                   ---GTGSEEE CS
  2OG-FeII_Oxy  85 pvnegerRvs 94 
                   pv++g  +++
    EFC39264.1 233 PVTKGT-KYI 241
                   ****98.443 PP

>> 2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   8.6e-07    0.0031       1      78 [.     147     235 ..     147     246 .. 0.72

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 8.6e-07
  2OG-FeII_Oxy_4   1 lsvssYekgdvllnHdDvle....geRrva.yilyleeeWkeddGGaLllsddeg.........dvtksivPkwnqlvlFevkeshsvaeva 78 
                     +++s+Ye g+++  H D        eR ++ +++yl++++k   GG+ ++++d +         ++ +++ P+++ql+lF+    h+   v+
      EFC39264.1 147 MRLSKYEPGEYFKIHTDGQFrrseHERSIYtLLIYLNQDFK---GGETRFYNDPTktdsdfeeySLLHTLKPSLGQLALFNQDFYHEGCPVT 235
                     6789*************853333356766415678888875...******976421223333335799************988778766665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (659 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       672  (0.0374812); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.49u 0.23s 00:00:00.72 Elapsed: 00:00:00.42
# Mc/sec: 4712.20
//
Query:       EFC39265.1  [L=767]
Description: hypothetical protein NAEGRDRAFT_81344 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (767 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2276  (0.126945); expected 358.6 (0.02)
Passed bias filter:                      219  (0.0122148); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.48
# Mc/sec: 4818.73
//
Query:       EFC39266.1  [L=288]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.3e-17   62.0   0.0    1.4e-15   58.0   0.0    2.1  2  2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily
     0.0045   17.4   0.1      0.013   15.9   0.0    1.8  2  2OG-FeII_Oxy    2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
       0.12   12.4   0.0       0.32   11.1   0.0    1.7  2  TetR_C_27       Tetracyclin repressor-like, C-terminal domain


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.033     2e+02       1      28 [.      64      90 ..      64     122 .. 0.84
   2 !   58.0   0.0   2.4e-19   1.4e-15      90     196 .]     175     269 ..     146     269 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.033
  2OG-FeII_Oxy_2  1 glllipnflsaeeaaellrelleegpfr 28
                    gl+++pn+ls  e  +ll++l+  + ++
      EFC39266.1 64 GLIYVPNYLSHDEGSKLLSTLD-NHSWY 90
                    789****************998.55554 PP

  == domain 2  score: 58.0 bits;  conditional E-value: 2.4e-19
  2OG-FeII_Oxy_2  90 pegwspnaalvnfYrdgariglHqDkeesaleapivSlSLGasatfrfgkesreeeiiailLesGdllvmggesrkay.Hgvprikkdtapelel 183
                     + + ++n++lv+ Y + ++i+ H+D+ +  +++ iv lSL  ++ + f ++++ +  +++ Le+++ll+m+ e r+ + Hg++r+k+        
      EFC39266.1 175 VIDDRINQCLVQEYYE-QSIAKHVDNVKV-FGKEIVCLSLVNECQMDFESANNPDMKFKLTLEPNSLLIMSKEGRYDWkHGIKRKKRF------- 260
                     556689********87.57********77.*********************************************************5....... PP

  2OG-FeII_Oxy_2 184 eelrtrRinlTfR 196
                          rRi+lTfR
      EFC39266.1 261 ----PRRISLTFR 269
                     ....59******9 PP

>> 2OG-FeII_Oxy  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       2.5   1.5e+04       8      18 ..     154     164 ..     154     171 .. 0.75
   2 !   15.9   0.0   2.2e-06     0.013       2      99 ..     181     270 ..     180     271 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 2.5
                   EEE-S------ CS
  2OG-FeII_Oxy   8 nyypphpdpev 18 
                   +yy++++dp++
    EFC39266.1 154 EYYENSNDPSS 164
                   58999999985 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 2.2e-06
                   --EEEEEEE-S---------EEEEEESSSEEEEEEE-TT---EEEETEEEE----TTEEEEEE-HHHHHHTTS-S----EEE----GTGSEEEEEEE CS
  2OG-FeII_Oxy   2 eellvlnyypphpdpevilglgahtdaslltillqddvgglevfkdgkwlrvppvdnslivniGdallflsngryksvlHrVlpvnegerRvsiayf 98 
                   +++lv++yy+ ++ ++v+   +  ++  +l++ + ++ + +e        + p  + +l++++++ l + + gry   +H++++ ++  rR+s++++
    EFC39266.1 181 NQCLVQEYYEQSIAKHVDNVKVFGKEIVCLSLVNECQ-MDFES------ANNPDMKFKLTLEPNSLLIMSKEGRYD-WKHGIKRKKRFPRRISLTFR 269
                   79**********9999844457778889999888888.88874......223445567888888855555555776.******9999999******9 PP

                   E CS
  2OG-FeII_Oxy  99 i 99 
                   +
    EFC39266.1 270 H 270
                   7 PP

>> TetR_C_27  Tetracyclin repressor-like, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   5.3e-05      0.32       5      49 ..       2      46 ..       1      58 [. 0.92
   2 ?   -2.8   0.0       1.1   6.4e+03      36      50 ..     188     202 ..     183     208 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 5.3e-05
                HHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHH-HHHHHHHHHHHH CS
   TetR_C_27  5 LrewlaalfeakrrkarddpelFatyvvlieeelevvekhieele 49
                L+++l al++ kr+++++ p l ++++++   +++v ++h+ ++ 
  EFC39266.1  2 LKKFLPALMHNKRNNFQSLPSLLSIVQKACYSTSDVSDQHVPTAS 46
                889*************************************98776 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.1
                 H-HHHHHHHHHHHHH CS
   TetR_C_27  36 eelevvekhieelee 50 
                  + + ++kh+++++ 
  EFC39266.1 188 YYEQSIAKHVDNVKV 202
                 456778888888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (288 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       423  (0.0235931); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.44u 0.22s 00:00:00.66 Elapsed: 00:00:00.39
# Mc/sec: 2227.41
//
Query:       EFC39267.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.067   14.2   1.5      0.067   14.2   1.5    2.9  2  DUF4834   Domain of unknown function (DUF4834)


Domain annotation for each model (and alignments):
>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -8.0   9.8         1   1.8e+04      82      82 ..      34      34 ..       2     130 .. 0.62
   2 ?   14.2   1.5   3.7e-06     0.067      30      80 ..     262     312 ..     231     313 .] 0.82

  Alignments for each domain:
  == domain 1  score: -8.0 bits;  conditional E-value: 1
     DUF4834 82 k 82
                 
  EFC39267.1 34 M 34
                1 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 3.7e-06
     DUF4834  30 fglgsrkkssksaqkqfgnstnsnqqksqsrsetkeegeiieeersekeak 80 
                 +g  s+++++ s++++f++s+n++++ +++ ++++ee++++e+e se+e++
  EFC39267.1 262 IGNTSKQTNKTSVSQGFAQSYNNSSAPTHNATQHEEEESEVEQEASEQEEQ 312
                 78899999999******************9999999999999888888665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2025  (0.112946); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.26s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 2068.41
//
Query:       EFC39268.1  [L=456]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.047   13.8   0.1       0.58   10.3   0.0    2.5  2  UBA_2     Ubiquitin associated domain (UBA)


Domain annotation for each model (and alignments):
>> UBA_2  Ubiquitin associated domain (UBA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   3.2e-05      0.58       2      30 ..      91     119 ..      91     127 .. 0.89
   2 ?    0.0   0.0     0.053   9.6e+02       3      24 ..     217     238 ..     210     242 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 3.2e-05
       UBA_2   2 dedvvsaLsktMGYdkdeIieaLekaeks 30 
                 d++ vs ++kt+ + k+e+ e L+ +e++
  EFC39268.1  91 DDEFVSFINKTLDFPKEEVEEILRGKEPK 119
                 8999********************99987 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.053
       UBA_2   3 edvvsaLsktMGYdkdeIieaL 24 
                 e++ + L+  +G  kd+ +eaL
  EFC39268.1 217 EKLDELLNPVLGQLKDDLVEAL 238
                 4444556777788899999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (456 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1467  (0.0818227); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.46
# Mc/sec: 2975.64
//
Query:       EFC39269.1  [L=470]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.15   12.3   0.3       0.51   10.6   0.3    2.0  1  IL4_i_Ig  Interleukin-4 inducing immunoglobulin-binding domai
        5.1    7.3   9.2       0.28   11.4   2.2    2.4  2  KOG2701   Coiled-coil domain-containing protein (DUF2037)


Domain annotation for each model (and alignments):
>> IL4_i_Ig  Interleukin-4 inducing immunoglobulin-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.3   5.7e-05      0.51       6      47 ..     328     369 ..     326     400 .. 0.91

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 5.7e-05
                 SSGGG-S-EEEE-S-BS--SS..-B--SEEE----------E CS
    IL4_i_Ig   6 seanerGswsdicdsnellspllvwttrsvCapenqdskrer 47 
                 s+ ++r s +++ + n++ls++  ++ +s+ +p n++++++ 
  EFC39269.1 328 SQSYRRNSMFEMSQTNNSLSSFNNFHLGSIPSPDNNNTNNNM 369
                 57899******************************9988765 PP

>> KOG2701  Coiled-coil domain-containing protein (DUF2037)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   2.2   3.1e-05      0.28      50     141 ..      75     183 ..      49     250 .. 0.74
   2 ?   -1.1   0.7      0.22     2e+03     111     140 ..     429     459 ..     390     469 .. 0.59

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 3.1e-05
     KOG2701  50 enktigekialtekivkalekm.kCPlelephqiqglDfsailpvvqWLvkrvletreekadf...............lrkfaalqfskay.elledke 131
                 +n+ +++++++ ++  +  + m  +P+ ++ +q q  D+++i  +++ ++++  ++r+ ++ +                ++f+++q  +   +++   +
  EFC39269.1  75 NNSRLRQQQQQQQQFNNNSPTMpLSPHPIHHQQQQSPDQANIQALINIVIQQPENMRMINNTNndlmmesspgipnneYESFNKMQIDDITcTTSPALS 173
                 488999999999999999999988*********************************999988889999999999999555555555544422222222 PP

     KOG2701 132 ekkkekvake 141
                 ++++++++++
  EFC39269.1 174 DQNNTNSINN 183
                 2222222222 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.22
     KOG2701 111 flrkfaalqfskay.elledkeekkkekvak 140
                     f+++++++ y  + e ++++kk+k+ k
  EFC39269.1 429 SSVTFNTNEYQDFYhGIHETQQKDKKRKALK 459
                 2344556666666644444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (470 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1591  (0.0887389); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.29s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2890.39
//
Query:       EFC39270.1  [L=544]
Description: hypothetical protein NAEGRDRAFT_59310 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (544 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       965  (0.0538234); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.75u 0.36s 00:00:01.10 Elapsed: 00:00:00.55
# Mc/sec: 2954.09
//
Query:       EFC39271.1  [L=381]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.2e-08   33.9   0.9    1.1e-07   32.2   0.9    1.9  1  SAM_1     SAM domain (Sterile alpha motif)
    7.2e-05   23.0  13.7     0.0047   17.2   8.6    3.1  2  RGS       Regulator of G protein signaling domain
     0.0017   18.4   0.3     0.0041   17.2   0.3    1.7  1  SAM_2     SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
      0.064   13.1   0.2       0.28   11.0   0.1    2.2  2  LacI      Bacterial regulatory proteins, lacI family
       0.31   11.3   5.0        1.5    9.1   2.4    2.4  2  Tctex-1   Tctex-1 family
       0.46    9.7   6.1       0.82    8.9   6.1    1.4  1  VSG_B     Trypanosomal VSG domain
        3.1    7.8   8.9        5.6    7.0   4.6    2.2  2  DUF87     Helicase HerA, central domain


Domain annotation for each model (and alignments):
>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.2   0.9   4.2e-11   1.1e-07       5      58 ..     319     373 ..     315     376 .. 0.95

  Alignments for each domain:
  == domain 1  score: 32.2 bits;  conditional E-value: 4.2e-11
                 HSSHHHHHHHTTSGGGHHHH.HTTTSSHHHHTTSCHHHHHHCTTTSHHHHHHHHH CS
       SAM_1   5 vedVgeWLesiglgqYadlF.rageidgdaLlllteddLeklgvtllGHrkkIly 58 
                 +++V e+L++ ++ +  +lF ++    ++ + ++te+d++klgv++lGH k++++
  EFC39271.1 319 QKSVEEFLKENHMDENWSLFkKKKLLVMKDIRDMTEEDYKKLGVKKLGHVKRLVR 373
                 689*************************************************986 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   8.6   1.8e-06    0.0047       2     115 ..     118     302 ..     117     305 .. 0.92
   2 ?    0.3   0.2      0.32   8.1e+02      14      33 ..     321     340 ..     313     363 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.8e-06
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS............................................................ CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkka............................................................ 40 
                 +es +++++g++ ++e+les  ++e+l F +a e + ++                                                            
  EFC39271.1 118 FESFIQQNDGKQRLKEYLESARNDEQLVFIEALEPWFSKnpkiqhrisscdeeldesdssdsnsvgslnsnlsnvmmtclendeifvdklmnikvidna 216
                 78999999**************************999999*********************************************************** PP

                 .........SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS..STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHH CS
         RGS  41 .........keqeelkkkakeIyneylapsspkelnidkklreelekrleke..qpsrklfeeaqeevfellekdsypkFlksely 115
                           ++ + ++    +++++l+++s+ eln+++k+++ ++k  +++  ++ +k+++ + ++v++ ++++ +++  k+e +
  EFC39271.1 217 tekvfgnvdIQHLSYLDISLIVVEKFLNDDSQFELNVSSKTKAAVNKAAKEQdeSEAKKVLKTLYQSVLSQMKEEVFNHLRKTEDF 302
                 *****998655556666677789*************************99988889999***************999988887766 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.32
                 HHHHHHHHTTCTHHHHHHHH CS
         RGS  14 lFreFlesefseenlsFwla 33 
                   +eFl++++ +en s++++
  EFC39271.1 321 SVEEFLKENHMDENWSLFKK 340
                 55789999999999887765 PP

>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.3   1.6e-06    0.0041       6      61 ..     319     374 ..     317     378 .. 0.94

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.6e-06
                 HHHHHHHHHHTTTGGGHHHHHHTTCSHHHHHTTSCHHHHHHTTHHHHHHHHHHHHH CS
       SAM_2   6 ledvaeWLrsiglkqytdnFrdagitgaelllrlteedLkrlGitsvghrkkilkk 61 
                 +++v e+L++  + +    F+++++  ++ +  +teed k+lG+ ++gh k++ +k
  EFC39271.1 319 QKSVEEFLKENHMDENWSLFKKKKLLVMKDIRDMTEEDYKKLGVKKLGHVKRLVRK 374
                 689*************************************************9887 PP

>> LacI  Bacterial regulatory proteins, lacI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0         2   5.2e+03      14      21 ..     106     113 ..     105     117 .. 0.81
   2 ?   11.0   0.1   0.00011      0.28      18      41 ..     241     268 ..     234     269 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2
                 HHHHHHCT CS
        LacI  14 aTVSrvLn 21 
                 aTVS  L+
  EFC39271.1 106 ATVSELLK 113
                 89999886 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00011
                 HHCTTS....SSSTHHHHHHHHHHHHHT CS
        LacI  18 rvLnnk....erVseetrerVeaameel 41 
                 ++Ln++     +Vs +t+  V++a++e+
  EFC39271.1 241 KFLNDDsqfeLNVSSKTKAAVNKAAKEQ 268
                 67888888889****************8 PP

>> Tctex-1  Tctex-1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0     0.094   2.4e+02       9      41 ..     166     198 ..     162     217 .. 0.87
   2 ?    9.1   2.4   0.00058       1.5       9      88 ..     260     339 ..     252     347 .. 0.76

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.094
                 HHHHHHCTSSS--CCCHHHHHHHHHHHHHHHHH CS
     Tctex-1   9 alesalesaesYdhekveqwnstiinsilkalk 41 
                  ++++l++ +s d++ v ++ns+++n +++ l 
  EFC39271.1 166 SCDEELDESDSSDSNSVGSLNSNLSNVMMTCLE 198
                 6999**999999**************9998877 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00058
                 HHHHHHCTSSS--CCCHHHHHHHHHHHHHHHHHHH..TS.SS....SCEEEEEEEEEE.TTTS-EEEEEEEES-TTT-EEEEEEE CS
     Tctex-1   9 alesalesaesYdhekveqwnstiinsilkalkse..stele..lpryKfivnvtivq.kkgqgmhsasgaywdektDgmvsfky 88 
                 a+++a +++   d+++++++ +t+ +s+l+++k+e  ++     ++ +K+ v +  ++ +++++ +s   ++ ++  D+ +s   
  EFC39271.1 260 AVNKAAKEQ---DESEAKKVLKTLYQSVLSQMKEEvfNH--LrkTEDFKIWVLSKAIEfSQKEEQKSVEEFLKENHMDENWSLFK 339
                 555555443...799999999999999999999885333..246**********9999667778889999999999999998644 PP

>> VSG_B  Trypanosomal VSG domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   6.1   0.00032      0.82      31     136 ..     258     377 ..     257     381 .] 0.65

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00032
       VSG_B  31 klaeaapeaikdeqevtkileeiealnlsladedwlnkfaeeedda...............katktkkaakkncgalkafWkeakkaakakkkk..... 109
                 k a +++++ +de+e++k+l+ +++  ls  +e+++n++ ++ed +               ++  ++  ++++  ++++  k++         k     
  EFC39271.1 258 KAAVNKAAKEQDESEAKKVLKTLYQSVLSQMKEEVFNHLRKTEDFKiwvlskaiefsqkeeQKSVEEFLKENHMDENWSLFKKK---------Kllvmk 347
                 56889999**************************************99988755443332222222222222222223322332.........134555 PP

       VSG_B 110 ...eltrpantrararanekiqqiaekaae 136
                    ++t+  ++++   +  +++++++k+ae
  EFC39271.1 348 dirDMTEEDYKKLGVKKLGHVKRLVRKTAE 377
                 444666666666666666666777766665 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.1     0.038        98     132     188 ..      94     166 ..      72     198 .. 0.57
   2 ?    7.0   4.6    0.0022       5.6      85     203 ..     219     371 ..     203     373 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.038
       DUF87 132 eekeklssdepveklleelk................kekeelrklknqaiarlldkledllrkggsfsnsstd 188
                 ++ ++++sd+ ++++ e lk                + ke+l++++n+ +   +++le  ++k+ ++++  ++
  EFC39271.1  94 TSANSTTSDSDFATVSELLKtynnfesfiqqndgkqRLKEYLESARNDEQLVFIEALEPWFSKNPKIQHRISS 166
                 5667777777777777777744444444444444433333444444444444444444444444444333333 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0022
       DUF87  85 a.........................kdkelkinpwsldpeelldllee.ddkpaaavqrsvleealdqaka........keekeklssdepvekllee 149
                 +                         +d ++++n++s +   + + ++e d+ +a +v++ +++++l+q+k+        +e+ + +   + +e++++e
  EFC39271.1 219 KvfgnvdiqhlsyldislivvekflnDDSQFELNVSSKTKAAVNKAAKEqDESEAKKVLKTLYQSVLSQMKEevfnhlrkTEDFKIWVLSKAIEFSQKE 317
                 4555555555555556666666666788999999999999999999999888888888*************9999999976677778889999999999 PP

       DUF87 150 lkkeke.elrklknqaiarlldkledllrkggsfsnsstdliallleklekegki 203
                  +k++e  l+++ ++  ++l +k++ l  k + +  +++d+ +l ++kl++ +++
  EFC39271.1 318 EQKSVEeFLKENHMDENWSLFKKKKLLVMKDIRD-MTEEDYKKLGVKKLGHVKRL 371
                 9988885677777777777777777777777777.89999999999999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2195  (0.122427); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 2195.67
//
Query:       EFC39272.1  [L=658]
Description: hypothetical protein NAEGRDRAFT_59311 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.2e-09   36.0   5.0       0.02   15.2   0.1    5.4  5  TPR_12        Tetratricopeptide repeat
    0.00095   19.0   0.1     0.0077   16.1   0.0    2.6  2  TPR_10        Tetratricopeptide repeat
     0.0016   18.8   3.1     0.0016   18.8   3.1    3.5  3  OmpH          Outer membrane protein (OmpH-like)
  ------ inclusion threshold ------
      0.036   14.6   3.8         12    6.5   0.1    3.6  3  TPR_19        Tetratricopeptide repeat
      0.038   14.6   7.6      0.065   13.8   0.4    3.6  4  DUF883        Bacterial protein of unknown function (DUF883)
       0.07   13.3   0.1       0.26   11.4   0.1    2.0  1  TrmO_C        TrmO C-terminal domain
      0.091   13.6   1.6       0.97   10.4   0.0    3.4  3  TPR_14        Tetratricopeptide repeat
       0.24   10.9   3.3         13    5.3   0.0    2.9  3  Peripla_BP_2  Periplasmic binding protein
       0.33   11.7   2.7        8.2    7.2   0.0    3.3  3  PMC2NT        PMC2NT (NUC016) domain
       0.35   11.4   0.1       0.35   11.4   0.1    3.3  3  TipAS         TipAS antibiotic-recognition domain
        2.9    8.1  12.1        1.5    9.0   0.0    5.0  6  TPR_7         Tetratricopeptide repeat
          5    7.1  10.7         53    3.9   0.0    5.0  5  TPR_1         Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0      0.11   1.6e+02       6      65 ..      52     111 ..      46     113 .. 0.83
   2 !   11.6   0.0   0.00017      0.26       8      71 ..     241     304 ..     234     308 .. 0.90
   3 ?    0.2   0.0      0.64   9.5e+02      19      57 ..     352     390 ..     349     395 .. 0.86
   4 ?    2.9   0.0     0.089   1.3e+02      17      42 ..     512     537 ..     508     543 .. 0.85
   5 !   15.2   0.1   1.3e-05      0.02       8      41 ..     546     579 ..     539     595 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.11
      TPR_12   6 lnnlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAl 65 
                 +++l ++l+ l++ ++A   l+ ++++    lG++h      +  L+ ++++ ++  eAl
  EFC39272.1  52 YYRLIDLLMDLKEIEQAKVELQYCIDVTVDFLGENHISMFKLREKLALIHFYNNNMIEAL 111
                 668888899999999999999999999999999999999999999999999999888887 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00017
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleea 71 
                 ++a++     r   A+  +ekal  a + +G+++ ++ ++l  L+ l+ ++++ye+ l++ ++a
  EFC39272.1 241 RVAQLFESERRIKLAILQYEKALTKAISFYGKNSIQVGEVLSPLSSLCNLAEKYEQGLSYAKRA 304
                 56777777888999******************************************99999998 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.64
      TPR_12  19 ydeAlellekaleiarrllGpdhpltattlrnLgrlyra 57 
                 y +A+++  + ++i+ + +G d+p  + + + L+  y++
  EFC39272.1 352 YIDAEKYISAGMNIVDKHYGRDNPVWILAAYSLASNYDL 390
                 899************999*****8888888888887765 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.089
      TPR_12  17 grydeAlellekaleiarrllGpdhp 42 
                 g  d  +++l+ a++++++ +G +++
  EFC39272.1 512 GSVDSGIQHLQNAMRLFEQQYGNEYL 537
                 6678899*************998875 PP

  == domain 5  score: 15.2 bits;  conditional E-value: 1.3e-05
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrllGpdh 41 
                 +la++ ++ g+ deA +lle++l++++++lG ++
  EFC39272.1 546 ELANLFNHSGNIDEAMSLLEASLQRVEKALGNES 579
                 6****************************99876 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       6.2   9.3e+03       8      23 ..      97     112 ..      96     113 .. 0.86
   2 !   16.1   0.0   5.1e-06    0.0077       7      39 ..     546     578 ..     544     579 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 6.2
      TPR_10   8 LanalrqrgrydeAea 23 
                 La +++  ++  eA++
  EFC39272.1  97 LALIHFYNNNMIEALK 112
                 8999999999999986 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 5.1e-06
      TPR_10   7 NLanalrqrgrydeAealleealairrrllGpd 39 
                  Lan+  + g+ deA+ lle +l++ +++lG++
  EFC39272.1 546 ELANLFNHSGNIDEAMSLLEASLQRVEKALGNE 578
                 699****************************76 PP

>> OmpH  Outer membrane protein (OmpH-like)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   1.2      0.67     1e+03      47     105 ..     203     270 ..     178     274 .. 0.63
   2 ?    2.2   5.9      0.14   2.1e+02      46      97 ..     401     451 ..     395     459 .. 0.58
   3 !   18.8   3.1   1.1e-06    0.0016       7      93 ..     547     635 ..     541     648 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.67
                 HHHHHHTTTS........-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..HHHHHHHHHHHHH CS
        OmpH  47 eelqkkakkl.e......keekeqelqkkeqelqqkqqqkaqelqkkqqellk..pildkinkaikev 105
                 ++l+k+++ l +      k + + e++k+++ + +  ++ aq ++++++  l+  +  + ++kai+ +
  EFC39272.1 203 DKLKKEENVLaKltltsyKSDTKAEIRKQKDSIFEIIKRVAQLFESERRIKLAilQYEKALTKAISFY 270
                 44444443333355555555666667777777777677776666666665555334456666666555 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.14
                 HHHHHHHTTTS....-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        OmpH  46 qeelqkkakkl.e..keekeqelqkkeqelqqkqqqkaqelqkkqqellkpildk 97 
                  ++      ++ +   ++++qel++ + el ++ q+k  e ++k + l++ i + 
  EFC39272.1 401 NDKV----GQMgTenIKQEQQELDNIQIELSEENQKKLDEWREKANNLFELIREV 451
                 2222....22222447788888888888888844444477777777766654444 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 1.1e-06
                 HHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTS......-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        OmpH   7 vqkileespegkaaqeqlekkfkklqaeleakekelqklqeelqkkakkle.....keekeqelqkkeqelqqkqqqkaqelqkkqqellkp 93 
                 ++ ++++s    +a++ le+  ++ +++l ++ k +q+   ++++ +   +     k eke+ +qk+ +++ ++++q++ e++k +q++ + 
  EFC39272.1 547 LANLFNHSGNIDEAMSLLEASLQRVEKALGNESKLYQEVSHAYKNIS---SlkglsKDEKEERFQKLLEKYDKEMDQAKHEVAKTNQQVSQT 635
                 677899999999*******************************7333...1346778888888***********************998875 PP

>> TPR_19  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.2      0.01        15      29      49 ..      53      73 ..      49      77 .. 0.92
   2 ?    0.1   0.0      0.78   1.2e+03      19      36 ..     314     331 ..     291     336 .. 0.55
   3 ?    6.5   0.1    0.0082        12       8      52 ..     522     568 ..     513     575 .. 0.68

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.01
      TPR_19 29 llLAeallalgqldeAealLd 49
                ++L+++l+ l+++++A+  L+
  EFC39272.1 53 YRLIDLLMDLKEIEQAKVELQ 73
                89***************9996 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.78
      TPR_19  19 qedpknaearllLAeall 36 
                 + + kn+e    LA+al+
  EFC39272.1 314 KLNKKNPEYEVKLAKALI 331
                 234455555555555555 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0082
      TPR_19   8 aeAlalleqalqedpk.....naearllLAeallalgqldeAealLdalp 52 
                 ++A++l+eq    + +      + a   LA++   +g++deA+ lL+a +
  EFC39272.1 522 QNAMRLFEQQ---YGNeylfeREFASTELANLFNHSGNIDEAMSLLEASL 568
                 5555555553...2222333233344578999999*********999876 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.64   9.6e+02      13      44 ..      12      43 ..       5      47 .. 0.84
   2 ?   -2.4   0.1         5   7.5e+03      32      62 ..     213     243 ..     202     248 .. 0.65
   3 ?    1.8   0.1      0.24   3.6e+02       7      45 ..     412     450 ..     407     456 .. 0.81
   4 ?   13.8   0.4   4.4e-05     0.065       2      60 ..     580     638 ..     579     650 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.64
      DUF883 13 dleellkeaadeageeaeelRerleerlerar 44
                +  e++++ +++ ++e+e lR++++e++ + r
  EFC39272.1 12 SSMEFTSSNNAKERDEVEILRAQIKEAFGNRR 43
                556889999999************99987655 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 5
      DUF883  32 lRerleerlerarerlrdaeeavaerakeaa 62 
                 ++  l+++ +++++++r++++++ e +k++a
  EFC39272.1 213 AKLTLTSYKSDTKAEIRKQKDSIFEIIKRVA 243
                 4555666667777777777777666666655 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.24
      DUF883   7 leslladleellkeaadeageeaeelRerleerlerare 45 
                 +++  ++l+++  e ++e +++++e Re++++ +e  re
  EFC39272.1 412 IKQEQQELDNIQIELSEENQKKLDEWREKANNLFELIRE 450
                 566667788888888999999999999999999888887 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 4.4e-05
      DUF883   2 eleaeleslladleellkeaadeageeaeelRerleerlerarerlrdaeeavaerake 60 
                 +l +e+ ++ +++ +l   ++de +e  ++l e+ ++++++a++++++++++v +  k 
  EFC39272.1 580 KLYQEVSHAYKNISSLKGLSKDEKEERFQKLLEKYDKEMDQAKHEVAKTNQQVSQTLKP 638
                 67899999*********************************************998775 PP

>> TrmO_C  TrmO C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1   0.00017      0.26       2      37 ..     421     456 ..     420     457 .. 0.94

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00017
      TrmO_C   2 kleVeFseeaeaqlqqlqksapdlkqlIeevLaqDP 37 
                 ++++e see +++l ++ ++a +l +lI+ev+++ P
  EFC39272.1 421 NIQIELSEENQKKLDEWREKANNLFELIREVIEMSP 456
                 689*****************************9877 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.1       4.2   6.3e+03       3      21 ..      51      69 ..      49      73 .. 0.83
   2 ?   -0.9   0.1       2.9   4.3e+03       6      29 ..     241     264 ..     236     266 .. 0.81
   3 ?   10.4   0.0   0.00065      0.97       6      30 ..     546     570 ..     543     577 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 4.2
      TPR_14  3 allalaeallalGdpdeAi 21
                 +++l ++l+ l + ++A 
  EFC39272.1 51 YYYRLIDLLMDLKEIEQAK 69
                589999******9999996 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 2.9
      TPR_14   6 alaeallalGdpdeAiallrrala 29 
                 + a++++  ++ + Ai  +++al 
  EFC39272.1 241 RVAQLFESERRIKLAILQYEKALT 264
                 668899999999999999999986 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00065
      TPR_14   6 alaeallalGdpdeAiallrralal 30 
                 +la ++ ++G+ deA+ ll++ l++
  EFC39272.1 546 ELANLFNHSGNIDEAMSLLEASLQR 570
                 6999******************997 PP

>> Peripla_BP_2  Periplasmic binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0    0.0086        13      94     130 ..     228     268 ..     201     301 .. 0.85
   2 ?   -1.7   0.0       1.2   1.8e+03      77     135 ..     519     578 ..     501     592 .. 0.72
   3 ?    4.9   0.3     0.011        17     110     136 ..     603     629 ..     602     654 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0086
                   S....HHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHHHH CS
  Peripla_BP_2  94 g....eslkeqiralgellgledeaeklvaeidsklaaaks 130
                   +    +s+ e i+ +++l+++e++ + ++ +++++l +a s
    EFC39272.1 228 IrkqkDSIFEIIKRVAQLFESERRIKLAILQYEKALTKAIS 268
                   355559***************************99998765 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.2
                   HHHHHHS-EEE----TTSHHHHHHH..HHHHHHTT-HHHHHHHHHHHHHHHHHHHHTS-TT CS
  Peripla_BP_2  77 ellksgiptvivessntgeslkeqi..ralgellgledeaeklvaeidsklaaaksaidse 135
                   + l++    ++++++n+ + +++++  ++l+ l+++  + +++++ ++  l+++++a+ +e
    EFC39272.1 519 QHLQNAMRLFEQQYGNE-YLFEREFasTELANLFNHSGNIDEAMSLLEASLQRVEKALGNE 578
                   55555555666666666.5555554226899999999999999999999999999998877 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.011
                   -HHHHHHHHHHHHHHHHHHHHTS-TT. CS
  Peripla_BP_2 110 ledeaeklvaeidsklaaaksaidsek 136
                   +e++++kl +++d+++++ak  +++ +
    EFC39272.1 603 KEERFQKLLEKYDKEMDQAKHEVAKTN 629
                   799*****************9998874 PP

>> PMC2NT  PMC2NT (NUC016) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.0    0.0055       8.2      19      56 ..     218     255 ..     216     272 .. 0.87
   2 ?   -2.2   0.0       4.7     7e+03      30      45 ..     438     453 ..     406     472 .. 0.65
   3 ?    2.8   0.1      0.13   1.9e+02      61      85 ..     599     623 ..     548     655 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0055
      PMC2NT  19 rsldpefaksldeqserllslinsllklaaskseisas 56 
                  s+++++++++++q++ + ++i+++++l +s+++i+  
  EFC39272.1 218 TSYKSDTKAEIRKQKDSIFEIIKRVAQLFESERRIKLA 255
                 589999***************************99764 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 4.7
      PMC2NT  30 deqserllslinsllk 45 
                 +e++++l +li ++++
  EFC39272.1 438 REKANNLFELIREVIE 453
                 3444555555555554 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.13
      PMC2NT  61 deddveekfksvvdvvDsllEkadt 85 
                 ++d+ ee+f+++ +  D+ +++a +
  EFC39272.1 599 SKDEKEERFQKLLEKYDKEMDQAKH 623
                 4444445666666666666665554 PP

>> TipAS  TipAS antibiotic-recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1       2.1   3.1e+03      24      51 ..     222     249 ..     195     268 .. 0.74
   2 ?   11.4   0.1   0.00023      0.35       7      72 ..     368     454 ..     364     475 .. 0.83
   3 ?    2.6   0.6      0.12   1.8e+02      20      56 ..     590     626 ..     568     647 .. 0.49

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 2.1
                 XXXXXXXXXXXXXXXXXXXXXXXX..XX CS
       TipAS  24 klskedweelkaelkelfaklaaalaag 51 
                 + +k+++++ k+   e+++++a++++++
  EFC39272.1 222 SDTKAEIRKQKDSIFEIIKRVAQLFESE 249
                 4466666666777777777777776554 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00023
                 HH--XXX......................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXX CS
       TipAS   7 erygdea.....................ayqeseekiaklskedweelkaelkelfaklaaalaagkdpdseeaqelaeehraliee 72 
                 ++yg+++                     + q+++ k+ ++++e++++ ++el+++  +l +  +++ d   e+a++l+e +r++ie 
  EFC39272.1 368 KHYGRDNpvwilaayslasnydllcsclQEQAMNDKVGQMGTENIKQEQQELDNIQIELSEENQKKLDEWREKANNLFELIREVIEM 454
                 5666655566666666666666666666668899***************************************************94 PP

  == domain 3  score: 2.6 bits;  conditional E-value: 0.12
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXX CS
       TipAS  20 ekiaklskedweelkaelkelfaklaaalaagkdpds 56 
                 ++i++l+   ++e+++++++l++k  + +++ k    
  EFC39272.1 590 KNISSLKGLSKDEKEERFQKLLEKYDKEMDQAKHEVA 626
                 3334444444444555555555555555533332222 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.0     0.097   1.4e+02       6      31 ..     243     266 ..     239     272 .. 0.87
   2 ?   -2.3   0.0       4.2   6.2e+03       4      24 ..     289     296 ..     286     303 .. 0.57
   3 ?   -3.1   0.0       7.3   1.1e+04       9      25 ..     382     398 ..     381     402 .. 0.78
   4 ?   -1.3   0.1       1.9   2.9e+03      15      25 ..     521     531 ..     518     536 .. 0.82
   5 ?    9.0   0.0     0.001       1.5       4      34 ..     546     577 ..     543     579 .. 0.89
   6 ?    0.3   0.3      0.64   9.5e+02      12      33 ..     604     623 ..     602     626 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.097
       TPR_7   6 arlysrlGdyeeAielyeqsLaltkd 31 
                 a+l++++++ + Ai  ye+  altk+
  EFC39272.1 243 AQLFESERRIKLAILQYEK--ALTKA 266
                 8999999************..88876 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 4.2
       TPR_7   4 nLarlysrlGdyeeAielyeq 24 
                 nLa             e yeq
  EFC39272.1 289 NLA-------------EKYEQ 296
                 555.............45555 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 7.3
       TPR_7   9 ysrlGdyeeAielyeqs 25 
                 ys   +y+ + ++++++
  EFC39272.1 382 YSLASNYDLLCSCLQEQ 398
                 77788999999999884 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 1.9
       TPR_7  15 yeeAielyeqs 25 
                  ++A +l+eq+
  EFC39272.1 521 LQNAMRLFEQQ 531
                 6899******7 PP

  == domain 5  score: 9.0 bits;  conditional E-value: 0.001
       TPR_7   4 nLarlysrlGdyeeAielyeqsL.altkdped 34 
                  La+l+   G+ +eA +l+e+sL +++k+ ++
  EFC39272.1 546 ELANLFNHSGNIDEAMSLLEASLqRVEKALGN 577
                 59*********************999888776 PP

  == domain 6  score: 0.3 bits;  conditional E-value: 0.64
       TPR_7  12 lGdyeeAielyeqsLaltkdpe 33 
                 + ++++++e y +  +++ + +
  EFC39272.1 604 EERFQKLLEKYDK--EMDQAKH 623
                 6799*********..9987765 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.3      0.13   1.9e+02       3      21 ..      51      69 ..      50      76 .. 0.92
   2 ?   -0.5   0.1      0.86   1.3e+03       7      22 ..      97     112 ..      96     112 .. 0.91
   3 ?    3.6   0.1     0.042        63       7      29 ..     242     264 ..     237     266 .. 0.87
   4 ?   -2.4   0.2       3.4     5e+03       6      21 ..     289     298 ..     286     305 .. 0.49
   5 ?    3.9   0.0     0.036        53       6      29 ..     546     569 ..     543     571 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.13
                HHHHHHHHHHHTT-HHHHH CS
       TPR_1  3 alynlGnayfklgkydeAl 21
                 +y+l  +++ l++ ++A 
  EFC39272.1 51 YYYRLIDLLMDLKEIEQAK 69
                59***************95 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.86
                 HHHHHHHTT-HHHHHH CS
       TPR_1   7 lGnayfklgkydeAle 22 
                 l++++f++++  eAl+
  EFC39272.1  97 LALIHFYNNNMIEALK 112
                 899********99996 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.042
                 HHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   7 lGnayfklgkydeAleyyekALe 29 
                  ++++ +  + + A+  yekAL+
  EFC39272.1 242 VAQLFESERRIKLAILQYEKALT 264
                 57889999999**********96 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 3.4
                 HHHHHHHHTT-HHHHH CS
       TPR_1   6 nlGnayfklgkydeAl 21 
                 nl+      +ky++ l
  EFC39272.1 289 NLA------EKYEQGL 298
                 444......4455444 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.036
                 HHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_1   6 nlGnayfklgkydeAleyyekALe 29 
                  l+n++ + g+ deA    e  L+
  EFC39272.1 546 ELANLFNHSGNIDEAMSLLEASLQ 569
                 69*************988887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (658 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2501  (0.139495); expected 358.6 (0.02)
Passed bias filter:                      676  (0.0377043); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.85u 0.35s 00:00:01.20 Elapsed: 00:00:00.53
# Mc/sec: 3745.30
//
Query:       EFC39273.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.8e-06   27.8   0.0      0.032   13.9   0.0    2.2  2  Abhydrolase_1  alpha/beta hydrolase fold
  ------ inclusion threshold ------
      0.062   12.6   0.0        6.2    6.0   0.0    2.3  2  Hydrolase_4    Serine aminopeptidase, S33
      0.069   12.8   0.0        0.1   12.2   0.0    1.1  1  Esterase       Putative esterase


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.0   5.4e-06     0.032      72     110 ..      68     106 ..      60     134 .. 0.88
   2 !   12.0   0.0     2e-05      0.12     206     253 ..     252     319 ..     183     322 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 5.4e-06
                    TSSEEEEEETHHHHHHHHHHHHHGGGEEEEEEESECSSC CS
  Abhydrolase_1  72 ddkltlvGhSmGGmialayaaeyperVkalvllgaidpa 110
                    + k++++  S GG ++++ a +yp+rVk+l l+++++ +
     EFC39273.1  68 NSKFNIISVSGGGPFGMHIAKKYPSRVKSLQLIAPVTRN 106
                    5799******************************95444 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 2e-05
                    C...................THHHHSEEEEEEETTCSSSCHHHHHHHHHC.HTSEEEEEEETCSSSHH CS
  Abhydrolase_1 206 e...................lknvlaptlvisgtsDplvppkaledlaql.lpkkrlvvisdagHlaf 253
                    +                   l+ ++ ptl+ ++  D+ v+++ +  +a + lp+++lv++ d+g l f
     EFC39273.1 252 IgyitdlllflqfskskkdyLQSIKTPTLIQASIFDKTVDYEDQIIYAFQhLPNSKLVTYGDCGQLFF 319
                    04445555555555566777889999***************5555555555*************8876 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0     0.001       6.2      75     112 ..      68     105 ..      55     148 .. 0.81
   2 ?    4.5   0.0     0.003        18     177     218 ..     262     304 ..     158     314 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.001
  Hydrolase_4  75 elplfllGhSmGGliallyllrypdkvaglilsaPalk 112
                  ++++ ++  S GG   ++++++yp++v+ l l+aP+ +
   EFC39273.1  68 NSKFNIISVSGGGPFGMHIAKKYPSRVKSLQLIAPVTR 105
                  557789999**************************975 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.003
  Hydrolase_4 177 ldamkrleeraakitlPllllhGeaDkvvdpeas.relyerlg 218
                  l+  k+ ++  ++i++P+l+  +  Dk vd+e++   ++++l+
   EFC39273.1 262 LQFSKSKKDYLQSIKTPTLIQASIFDKTVDYEDQiIYAFQHLP 304
                  455555566678888****************999655555555 PP

>> Esterase  Putative esterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   1.7e-05       0.1     106     198 ..      61     148 ..      50     160 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.7e-05
                 HHHHCSEECCCEEEEEETHHHHHHHHHHHCSTTTCCEEEEES--S-CCHCHHHCTTCCHHHCC-CCCCHCHHCHTTSEEEEEEEECTTBCCCH CS
    Esterase 106 ldanfrtapdgravaGqSmGGlgALilalkhpdrFgsvssfSpivnpsnamWgqeekeawqendpvllakelsaslkalriyldvGtseddlg 198
                  ++ f ++++   ++  S GG + +++a k+p r +s    +p+  ++n m+g+ e+++  +   +++  ++ ++  +  i+ ++G+++dd +
  EFC39273.1  61 MNHLFGSNSK-FNIISVSGGGPFGMHIAKKYPSRVKSLQLIAPV--TRNLMIGRGESPK--KISNLVNLMNEKQETNEEIIVSKIGDQSDDSN 148
                 5555666666.66777899************************9..99******88887..8888888888899999999999****999654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       422  (0.0235373); expected 358.6 (0.02)
Passed bias filter:                      276  (0.0153941); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2077.48
//
Query:       EFC39274.1  [L=578]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-10   40.2   0.4    1.2e-08   34.5   0.4    2.3  1  Hydrolase_4    Serine aminopeptidase, S33
      5e-07   30.6   0.1    8.9e-07   29.7   0.1    1.4  1  Abhydrolase_6  Alpha/beta hydrolase family
    1.1e-05   25.0   0.1      0.008   15.7   0.1    2.3  2  Peptidase_S9   Prolyl oligopeptidase family
    0.00032   20.4   0.1       0.38   10.3   0.2    2.3  2  Abhydrolase_1  alpha/beta hydrolase fold
      0.005   15.6   0.4      0.065   11.9   0.1    2.1  2  AXE1           Acetyl xylan esterase (AXE1)
  ------ inclusion threshold ------
      0.053   13.2   0.3      0.094   12.4   0.3    1.3  1  PAP2_3         PAP2 superfamily
      0.054   12.7   0.0      0.084   12.1   0.0    1.3  1  Acyl_transf_2  Acyl transferase


Domain annotation for each model (and alignments):
>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   0.4   4.7e-12   1.2e-08       2     232 ..     333     552 ..     332     556 .. 0.77

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 4.7e-12
  Hydrolase_4   2 epkavvvlvHGlaehsgryaelaeaLaaqGfavyalDhrGhGrsegkrghvpsfddyvdDlaafvekvkeehpelplfllGhSmGGliallyllrypd 99 
                  + k++vv+vHG     + + e   +  + G++v+ +D   hG s+g  g    + +++  +  +++ ++   p+ +++ +G S+G++ ++ ++ + p+
   EFC39274.1 333 NSKKAVVIVHGAFYDRRDVLEHLPYIHKLGVHVLLFDMLNHGVSDGDEGCSLGYREWMGVM-GAIDYLEGIVPDVEVVAFGSSTGAASSIVAASQDPR 429
                  6799*********************************************999999998755.6669999999************************** PP

  Hydrolase_4 100 kvaglilsaPalkikaklkappllklllkllgkllpklqvsnnlkadslsrdpevvaayeadplvhgkitvrlllelldamk...rleeraakitlPl 194
                   ++++i  +P+ +   +  ++ +l+     l k   + q+  +l a  + ++ +++      +l++++++v + + ++d      ++ +   +++ Pl
   EFC39274.1 430 -IKAIIAENPFAERTLQ--IKDVLES---ALYKNGWSHQL-PSLFAGIIESYGKFIP-----ELLIRGVSVLVNWRMCDFSVnpyHASDAMREMSKPL 515
                  .**********887654..4444444...44444444445.3345556666666665.....677888888888888888761124566666666*** PP

  Hydrolase_4 195 lllhGeaDkvvdpeasrelyerlgskdktlklypglyH 232
                  ll+h++ Dkvvd + s+ ++ +l+s   ++ + + + H
   EFC39274.1 516 LLMHSKTDKVVDFKHSQ-ILSSLASGPIEYWIVEDAPH 552
                  ************88775.44555555555555555555 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.1   3.5e-10   8.9e-07       1     213 [.     338     558 ..     338     566 .. 0.59

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 3.5e-10
                    EEEE--GC.....G.CHHHHHHHHCCTCEEEEE--TTST...S-GGCS--HHH......CHHH.HHHHCCTT..TTSEEEEEETCHHHHHHHHHHC CS
  Abhydrolase_6   1 vlllHGagssassW.lvapLaallaagvhvlapDlpGhG...rsdpppldled......ladl.aalldelaagggpvvlvGHSlGGalalaaapl 85 
                    v+ +HGa++++++     +L +    gvhvl +D  +hG   ++++  l++++      + d+ + ++ ++      vv++G S G+a +  aa++
     EFC39274.1 338 VVIVHGAFYDRRDVlE--HLPYIHKLGVHVLLFDMLNHGvsdGDEGCSLGYREwmgvmgAIDYlEGIVPDVE-----VVAFGSSTGAASSIVAASQ 426
                    799***9987666632..555555557999********9555566666999886665555777666777775.....8********9966665556 PP

                    C..EE..EEES-..----TTTS----TTHHHHHHTT-C.CCCHCCH......S-HSCCCCHHHCCCCHCHCCCGHHHHCCHHCHTTCCHHTT-TTG CS
  Abhydrolase_6  86 alvvg..vlldppptalpagllaaalelllallallrl.lawlsre......plprlfladedadaawrarlarlaallaglgllpaaawadlpvp 172
                     ++++  ++ +p   a +++ + ++le +l  +++ +  + ++++       + p+l++++++  + +++r  + +     + +++ +a + +  p
     EFC39274.1 427 DPRIKaiIAENP--FAERTLQIKDVLESALYKNGWSHQlPSLFAGIiesygkFIPELLIRGVS--VLVNWRMCDFS----VNPYHASDAMREMSKP 514
                    655554566666..4444444444444444333322222222211112112233335555444..44444442222....4445568899999999 PP

                    CEEE.CTT-CHHHHCHHCCCH...STTEEET.CE...SSS.-HHHHS CS
  Abhydrolase_6 173 llvl.ggeDplvprllerlla...qagarlp.vvlpgaGH.lphlee 213
                    ll++  ++D++v     ++l    +     + +++++a H ++h  +
     EFC39274.1 515 LLLMhSKTDKVVDFKHSQILSslaSGPI--EyWIVEDAPHsCIHR-H 558
                    9777459999999666677776333444..369999*99988776.4 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.0    0.0014       3.6      53     107 ..     397     448 ..     384     466 .. 0.77
   2 !   15.7   0.1   3.1e-06     0.008     132     209 ..     500     575 ..     494     578 .] 0.81

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0014
                   HHHHHTTS--GGGEEEEEETHHHHHHHHHHHH-GGG-SEEEEESE---CCCHHCS CS
  Peptidase_S9  53 ealakegyvdserlaitGgSyGGyltgaalnqrpdlFkaavaevpvvdvlrydsd 107
                   ++l  eg+v   +++++G S G   + +a+ q + + ka++ae+p+++ + + +d
    EFC39274.1 397 DYL--EGIVPDVEVVAFGSSTGAASSIVAASQ-DPRIKAIIAENPFAERTLQIKD 448
                   555..667777789**************9995.5556*********988777666 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 3.1e-06
                   HHH-CGGG--.---EEEEEEETT-SSS-THHHHHHHHHHH--S-SEEEEEETTS-SSTTSSHHHHHHHHHHHHHHHHHC CS
  Peptidase_S9 132 spyspldnvk.aypplLlihGlaDdrvppaealklvaaLqkkgknvlllifpdegHgvgkprakveelarllaFlkeal 209
                   +py+  d+++  ++plLl+h+ +D+ v ++++   ++ L +   ++++ i  d+ H++     k e  +r+ +Fl+++l
    EFC39274.1 500 NPYHASDAMReMSKPLLLMHSKTDKVVDFKHSQI-LSSLAS--GPIEYWIVEDAPHSCIHRHLKDEFEERVISFLQKYL 575
                   45555555557999****************9854.555554..67*************9777777************98 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.2   0.00015      0.38       2     106 ..     337     438 ..     336     446 .. 0.81
   2 !    8.1   0.0   0.00071       1.8     175     250 ..     442     552 ..     438     557 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00015
                    EEEEE-STTTCGGGGTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB.CHHSHHH.HHHHHHHHHHHCTTSSEEEEEETHHHHHHHHHHHHHGG CS
  Abhydrolase_1   2 vlvilhGlpgssdvwaerglapaLakdgfdvillDlrGvgySspapacinddygtas.vaddldrildalgddkltlvGhSmGGmialayaaeype 96 
                    ++vi+hG         e    p++ k g +v+l+D++++g S+    c    y+ ++ v   +d++    +d +++  G S G + +  +a++   
     EFC39274.1 337 AVVIVHGAFYDRRDVLE--HLPYIHKLGVHVLLFDMLNHGVSDGDEGCSL-GYREWMgVMGAIDYLEGIVPDVEVVAFGSSTGAASSIVAASQD-P 428
                    68888887775555555..56777777*********************76.454443277788899*******************999999995.5 PP

                    GEEEEEEESE CS
  Abhydrolase_1  97 rVkalvllga 106
                    r+ka+++ ++
     EFC39274.1 429 RIKAIIAENP 438
                    6***999887 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00071
                    HHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHC..................................THHHHSEEEEEEETTCSSSCHHHHHHHHHC CS
  Abhydrolase_1 175 sdnasslatgalksieqwpttdsaklllrlre..................................lknvlaptlvisgtsDplvppkaledlaql 236
                    ++ ++ ++ ++++++++w+  + + + + +++                                   +++++p l++++ +D++v+ k++  l +l
     EFC39274.1 442 RTLQIKDVLESALYKNGWSHQLPSLFAGIIESygkfipellirgvsvlvnwrmcdfsvnpyhasdaMREMSKPLLLMHSKTDKVVDFKHSQILSSL 537
                    667788888999999999999999999999999999999999999999999999999999999999999999***************999999999 PP

                    HTS.EEEEEEETCSS CS
  Abhydrolase_1 237 lpk.krlvvisdagH 250
                     ++  ++++++da H
     EFC39274.1 538 ASGpIEYWIVEDAPH 552
                    888888888888887 PP

>> AXE1  Acetyl xylan esterase (AXE1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0     0.033        85      65     117 ..     318     370 ..     304     397 .. 0.72
   2 !   11.9   0.1   2.5e-05     0.065     173     208 ..     405     440 ..     386     457 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.033
                 GGEEEEEEEEEES.SSSSEEEEEEEE-TT--GGGHHHHHHHHH.TT-EEEEEE- CS
        AXE1  65 rgarikaklvlPkekeeklPavvefhGYegsrgeihdllnyaa.aGyavvvmdv 117
                 +++ +++++v  +  ++   avv  hG   +r ++ ++l y    G+ v+  d+
  EFC39274.1 318 KNKMLRGWYVEAN-DKNSKKAVVIVHGAFYDRRDVLEHLPYIHkLGVHVLLFDM 370
                 566789*****99.6666678888899999999999999997525777665554 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 2.5e-05
                 EEEEEEEEETHHHHHHHHHHHH-SS-SEEEEES-SS CS
        AXE1 173 eeRvavlGasqGGalalavaalekrikavvadyPfL 208
                 +  v+++G+s G a ++++a+ ++rika++a+ Pf 
  EFC39274.1 405 DVEVVAFGSSTGAASSIVAASQDPRIKAIIAENPFA 440
                 456899*****************************6 PP

>> PAP2_3  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.3   3.7e-05     0.094      53     128 ..     143     219 ..     138     220 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.7e-05
      PAP2_3  53 lrrrerlreflttlllatllgllvyalfPa..agPrlleeagfvdtvaaaslagalrdgasravllrgtienglaafP 128
                 +r++++  +f++t +++++lg++++a++ +  ++  ++++a +v++ a+++l + +++  +r+++++++i + l++fP
  EFC39274.1 143 TRKTSMIIKFIVTCAALNILGFITFAAIVTfvLPNLFMHPAAYVSVSAKHHLLH-EDATLYRKLVHTANIPETLVTFP 219
                 6888899999***********99999876532566556****************.8888899***************9 PP

>> Acyl_transf_2  Acyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   3.3e-05     0.084      10      75 ..     317     379 ..     308     426 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 3.3e-05
                    TTTEEEEEEEE---TTS---S-EEEEE-TT-GGGGGGHHHHHHHHTTT--EEEE---B-------- CS
  Acyl_transf_2  10 eeerkirvwetlpkekvdkrnntiviasgfarrmdhfaglaeylsengfhvirydslnhvglssge 75 
                    e+++ +r w     +k +k+   +++   f  r d +  l  y+ + g hv+ +d lnh g+s g+
     EFC39274.1 317 EKNKMLRGWYVEANDKNSKK-AVVIVHGAFYDRRDVLEHL-PYIHKLGVHVLLFDMLNH-GVSDGD 379
                    789999***99887776655.5666777788888999887.6*****************.788875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (578 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       661  (0.0368676); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.70u 0.37s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 3219.10
//
Query:       EFC39275.1  [L=468]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.1e-09   37.6   0.4    4.1e-09   36.6   0.4    1.5  1  NAAA-beta  beta subunit of N-acylethanolamine-hydrolyzing aci


Domain annotation for each model (and alignments):
>> NAAA-beta  beta subunit of N-acylethanolamine-hydrolyzing acid amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.6   0.4   2.3e-13   4.1e-09       1      43 [.      97     139 ..      97     154 .. 0.84

  Alignments for each domain:
  == domain 1  score: 36.6 bits;  conditional E-value: 2.3e-13
   NAAA-beta   1 gpvpwytinLDlpPeeRWtqvakdykpelksliqvlkdllksl 43 
                 +p+p+y++nL+ ++++RW++++ d+ + lk l ++l +++ + 
  EFC39275.1  97 KPIPKYVVNLNMDAKKRWKHIVMDMIEPLKLLAKYLTNVYQDD 139
                 59***********************************998654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1920  (0.107089); expected 358.6 (0.02)
Passed bias filter:                      633  (0.0353059); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.47
# Mc/sec: 2975.74
//
Query:       EFC39276.1  [L=937]
Description: HECT domain-containing ubiquitin ligase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.9e-85  286.0   2.6      6e-85  285.4   0.1    2.3  2  HECT           HECT-domain (ubiquitin-transferase)
    2.8e-20   72.3   6.5    2.6e-08   34.4   0.0    4.8  4  WD40           WD domain, G-beta repeat
    1.6e-05   23.8   0.8     0.0077   15.0   0.2    2.4  2  Nucleoporin_N  Nup133 N terminal like
    5.7e-05   23.3   0.6       0.15   12.4   0.2    3.1  3  ANAPC4_WD40    Anaphase-promoting complex subunit 4 WD40 doma
  ------ inclusion threshold ------
      0.021   13.5   7.6      0.042   12.5   0.3    3.2  4  Nup160         Nucleoporin Nup120/160
      0.022   15.3   0.0         25    5.5   0.0    4.3  5  PQQ_3          PQQ-like domain


Domain annotation for each model (and alignments):
>> HECT  HECT-domain (ubiquitin-transferase)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.4       0.2   6.1e+02      76     109 ..     453     486 ..     424     536 .. 0.64
   2 !  285.4   0.1     2e-88     6e-85       2     306 ..     635     936 ..     634     937 .] 0.96

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.2
                 -TCHHHHH-HHHHHHHHHHH..HS-GGG...GT- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT  76 tledleeidpelakslkellslesnteevedlaL 109
                  l++ + +d +++k++k+l++ +++++  +d+++
  EFC39276.1 453 YLDECKTLDDQIEKTIKYLKQQQDDESLGSDVDI 486
                 46788999************66555544444444 PP

  == domain 2  score: 285.4 bits;  conditional E-value: 2e-88
                 HHHHHHT-GGGSSEEESSTTSSSEEE-TTHHHHS.....HHHHHHHHHHHHHTT--BSS-B-HHHHHHHTT-.---TCHHHHH-HHHHHHHHHHH..HS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT   2 llskelldpklglfeeesedsgtlypkpssseee.llklfeflGkvlGkaiyeeilldlpfsraflkfllgeekitledleeidpelakslkellsles 99 
                 lls+++l+p+  lf  ++  ++t++p+p s+ +  +l++f+f+Gk++Gkai ++ ++d +f+++++k++ g +++++edle +dp+++ slk+ll le 
  EFC39276.1 635 LLSQQILNPNNALF-IKTGPNNTYHPNPASAVNGdHLQYFQFIGKLIGKAISDNKIMDTHFTKVIFKLMAG-KPVMFEDLEAVDPTMYLSLKKLLLLE- 730
                 89************.68999********9866559889*********************************.6**********************774. PP

                 -GGG...GT-BSEEEEE.TTEEEEEESSTTGGGSB--TTTHHHHHHHHHHHHHTGGGHHHHHHHHHHHHTTS-HHHHTTS-HHHHHHHHBCSSS.--HH CS
                 xxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT 100 nteevedlaLtFtipen.agasatieLipnGanipVtnenkkeYiklyvnyllkksvekqleaflkGfsevipskalklfdaeelellisGedelidve 197
                 + e++  +++tFt + n +g+++  eL+ nGa+i+V++ nk+e++++y +++l +sv++q+e++l+G++ev+p + l++f++ elell++G++e ++++
  EFC39276.1 731 DIENI--MEMTFTADLNdFGENNVYELCFNGAEIEVNDGNKHEFVEAYSKWKLVESVRPQVEKMLEGIYEVLPPEFLTIFSETELELLLCGSRE-VSIS 826
                 45445..89************************************************************************************9.**** PP

                 HHHHTEEEETT--TTSHHHHHHHHHHHHS-HHHHHHHHHHHHSSSS--TTCGGG-B--EEEEE-S..-TTS--EEEGGGTEEEE---SSHHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        HECT 198 dlrrnteykggynaesetiewlweilkefspeekrlfLqFvTgssrlPlgGfaelhpkftierkskedetrLPtahTCfnlLklpdYsskeilkekLlt 296
                 ++++n++y+gg++ +++t++++we+++++s+ + +++LqF Tg+s lP  Gf+ l+p+ft     + ++++LP ahTC n++++p+Y+skei+ke+   
  EFC39276.1 827 QWKDNISYEGGFDTDHPTVQYFWEMIEGYSQTQIAQLLQFSTGTSCLPSDGFEGLTPPFTLCLLRNVSTDHLPVAHTCLNRIDIPPYESKEIMKERFGK 925
                 **************************************************************99999******************************** PP

                 HHHHH.H--XX CS
                 xxxxx.xxxxx RF
        HECT 297 Aieet.egFel 306
                 Ai+++ +gF+l
  EFC39276.1 926 AIRYGsQGFSL 936
                 *********98 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.4   0.00071       2.1      10      38 .]     129     156 ..     120     156 .. 0.83
   2 !   34.4   0.0   8.8e-12   2.6e-08       1      38 []     160     198 ..     160     198 .. 0.97
   3 !   13.0   0.1   4.8e-05      0.14       2      37 ..     203     237 ..     202     238 .. 0.85
   4 !   15.6   0.0   7.5e-06     0.022       2      38 .]     243     280 ..     242     280 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00071
                 SSS.EEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  10 Hss.vtslafspdgawlasGsdDgtvriWd 38 
                 H+  +t++++  +  w  ++s D+++  Wd
  EFC39276.1 129 HFYkITCIKVENNRIW--TSSLDKNICCWD 156
                 6235************..6888*******9 PP

  == domain 2  score: 34.4 bits;  conditional E-value: 8.8e-12
                 TEEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   1 gqclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 g+c++ + GH + vt+l+ +  +++l sGs+D+tvr+Wd
  EFC39276.1 160 GECIKLFQGHtKAVTCLKIDMKNNLLYSGSYDRTVRVWD 198
                 689*******999*************************9 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 4.8e-05
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriW 37 
                 +c ++++   +++t+la+s+d  + +sG  D ++ ++
  EFC39276.1 203 TCKQVFDSNeNWITCLAVSSDYLF-CSGY-DSSISVY 237
                 588999999999****99999998.4677.****987 PP

  == domain 4  score: 15.6 bits;  conditional E-value: 7.5e-06
                 EEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +++ +l GH + v ++ + ++   l +++ D+tvr+Wd
  EFC39276.1 243 KKIAKLNGHvKKVEDMFYEHSEGILYTSGADCTVRMWD 280
                 6788999**999999988888888988888*******9 PP

>> Nucleoporin_N  Nup133 N terminal like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.2   2.6e-06    0.0077     163     244 ..     124     211 ..     123     226 .. 0.70
   2 !    6.6   0.0   0.00092       2.7     198     244 ..     249     293 ..     227     308 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 2.6e-06
                    EC-SSS-CEEEEEEEEE-SSSS-.............--SSS--G----GG-EEEEEEECCTCEEEEEETTSEEEEEEEETTCEE-EEEEEEE CS
  Nucleoporin_N 163 yrdssgwpslkckkicltkgglssll..........silpgvlsgasereeivqlridssrrilytlsskgvirvydlsasngesslksdid 244
                    y++ + +++++c k+ +     ssl           +   ++++     +++++l+id + ++ly+ s ++++rv+d++++   ++++ d +
     EFC39276.1 124 YKKFKHFYKITCIKVENNRIWTSSLDkniccwdketGECIKLFQ--GHTKAVTCLKIDMKNNLLYSGSYDRTVRVWDIETQ--TCKQVFDSN 211
                    56666667777777666555555444544444444444666666..7899*****************************65..555555554 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.00092
                    ---GG-EEEEEEECCTCEEEEEETTSEEEEEEEETTCEE-EEEEEEE CS
  Nucleoporin_N 198 asereeivqlridssrrilytlsskgvirvydlsasngesslksdid 244
                    +   +++  +  ++s +ilyt  +++++r++d+s+   e+ +++++ 
     EFC39276.1 249 NGHVKKVEDMFYEHSEGILYTSGADCTVRMWDISSL--ECIKVHSCR 293
                    347889999999**********************33..566666555 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.2   5.1e-05      0.15      34      88 ..     166     219 ..     131     223 .. 0.78
   2 !    7.8   0.0    0.0014       4.1      18      80 ..     233     294 ..     221     306 .. 0.85
   3 ?   -3.4   0.0       4.3   1.3e+04      47      75 ..     674     700 ..     671     707 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 5.1e-05
  ANAPC4_WD40  34 edkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclg 88 
                   +++ + v++L+  ++++lL  +  d +vr+ d+e++++ + ++ +++  +tcl 
   EFC39276.1 166 FQGHTKAVTCLKIDMKNNLLYSGSYDRTVRVWDIETQTCKQVFDSNEN-WITCLA 219
                  4678999************************************99998.699996 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0014
  ANAPC4_WD40  18 ellvfRl.ngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvks 80 
                  ++ v+ l  g+++ +l  +++ ++v+++ +++++ +L  + +d +vr+ d++s ++++  s+ +
   EFC39276.1 233 SISVYELkTGKKIAKL--NGHVKKVEDMFYEHSEGILYTSGADCTVRMWDISSLECIKVHSCRE 294
                  5666666346888888..78999********************************998887765 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 4.3
  ANAPC4_WD40  47 kpdgklLavaysdgevrlldaesgkvvhs 75 
                  +  gkl+  a+sd+++  +d + +kv+ +
   EFC39276.1 674 QFIGKLIGKAISDNKI--MDTHFTKVIFK 700
                  5668899999999975..56666666655 PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.4      0.15   4.6e+02     183     472 ..      44      90 ..      12     103 .. 0.55
   2 ?   -2.5   0.0      0.49   1.5e+03     225     254 ..     135     164 ..     132     170 .. 0.87
   3 ?   12.5   0.3   1.4e-05     0.042     225     259 ..     175     211 ..     154     222 .. 0.85
   4 ?    3.5   0.0    0.0073        22     232     265 ..     266     297 ..     239     384 .. 0.67

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.15
                 EEEEE-------B--TTTT.TSS--SS---TT-ECEEEEET.....TTTEEEEEETT-EEEEEETTTTEEEEEEE--.-SSSTTS--SSEESEEESSSS CS
      Nup160 183 kesvfepksfllslsgllglladpsrrksgasvalsldvavavveigqtylfalsrdgkLrvWnlltgkclatidllrdeeaqdessskstldpaessl 281
                 k++++ p+++  +l+ +++ l+d+++++s+                                                                     
  EFC39276.1  44 KPTTLTPTTS-ATLRAFTSNLSDSTKTQSSE-------------------------------------------------------------------- 73 
                 3334444443.44444444444444444444.................................................................... PP

                 EEEE..........E--GGG-EEEEEEEEEEE-...SSSEEEEES-S------S-TT--EEEEEEEEE-TTEEEEEEEEEETTEEEEEEEEEE-SS-SS CS
      Nup160 282 irvsdggqsylvvtyspssggefkvwkvkkedtsvslglvdlfleqtivpadpdssnvweLrDfaltssekgfelwalwknnegsvlkvlkinfesdea 380
                                                                                                                    
  EFC39276.1   - ---------------------------------------------------------------------------------------------------   -
                 ................................................................................................... PP

                 -.EEEEEE--------TTTTTS--SSGGG-SSHHHHHHHHH--.-HHHHHHHHHHHTTSS--STHHHTS-HHHHHHHHHHHHHTTS-B-SSS CS
      Nup160 381 dtdddWssvsaseritdketlgdeedveeatkeyldrilepGrFsnavletALsifrrnlsssssvkslssaelkeevcsaveseilndvse 472
                                                                                           +++ +++ + ++++d+s+
  EFC39276.1  74 --------------------------------------------------------------------------SSTMRTSFD-NVQQDTSN 90 
                 ..........................................................................444444444.33344444 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.49
                 ....TTTEEEEEETT-EEEEEETTTTEEEE CS
      Nup160 225 vveigqtylfalsrdgkLrvWnlltgkcla 254
                 +++++++ + + s+d+++  W+ +tg c+ 
  EFC39276.1 135 CIKVENNRIWTSSLDKNICCWDKETGECIK 164
                 6667899999****************9986 PP

  == domain 3  score: 12.5 bits;  conditional E-value: 1.4e-05
                 ......TTTEEEEEETT-EEEEEETTTTEEEEEEE-- CS
      Nup160 225 vvei..gqtylfalsrdgkLrvWnlltgkclatidll 259
                 + +i  ++++l++ s d+++rvW+++t++c  ++d +
  EFC39276.1 175 CLKIdmKNNLLYSGSYDRTVRVWDIETQTCKQVFDSN 211
                 44446699**********************9998877 PP

  == domain 4  score: 3.5 bits;  conditional E-value: 0.0073
                 EEEEEETT-EEEEEETTTTEEEEEEE--.-SSST CS
      Nup160 232 ylfalsrdgkLrvWnlltgkclatidllrdeeaq 265
                 +l++   d ++r+W+++++ c+ + ++   e++ 
  EFC39276.1 266 ILYTSGADCTVRMWDISSLECIKVHSCR--EYSH 297
                 678888999*************999998..5544 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.58   1.7e+03      22      40 .]     141     159 ..     138     159 .. 0.84
   2 ?    5.5   0.0    0.0084        25      21      40 .]     182     201 ..     173     201 .. 0.93
   3 ?    1.8   0.0      0.12   3.6e+02      17      40 .]     218     241 ..     210     241 .. 0.87
   4 ?    0.9   0.0      0.24     7e+02      20      38 ..     263     281 ..     263     283 .. 0.88
   5 ?   -3.4   0.0       5.3   1.6e+04      23      40 .]     305     321 ..     303     321 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.58
       PQQ_3  22 glvyvgtgdGtlyAlDaet 40 
                 +++ +++ d ++++ D et
  EFC39276.1 141 NRIWTSSLDKNICCWDKET 159
                 67888899********998 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0084
       PQQ_3  21 gglvyvgtgdGtlyAlDaet 40 
                 ++l+y g++d t++  D et
  EFC39276.1 182 NNLLYSGSYDRTVRVWDIET 201
                 689**************998 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.12
       PQQ_3  17 pavdgglvyvgtgdGtlyAlDaet 40 
                 +av+ ++++++++d ++  ++ +t
  EFC39276.1 218 LAVSSDYLFCSGYDSSISVYELKT 241
                 699************999988776 PP

  == domain 4  score: 0.9 bits;  conditional E-value: 0.24
       PQQ_3  20 dgglvyvgtgdGtlyAlDa 38 
                 ++g++y+++ d t+++ D 
  EFC39276.1 263 SEGILYTSGADCTVRMWDI 281
                 579************9997 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 5.3
       PQQ_3  23 lvyvgtgdGtlyAlDaet 40 
                  +y++ +  ++y++++et
  EFC39276.1 305 NIYISQP-QNIYSYNTET 321
                 5677666.899**99998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (937 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       813  (0.0453455); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.82u 0.36s 00:00:01.18 Elapsed: 00:00:00.53
# Mc/sec: 5318.45
//
Query:       EFC39277.1  [L=402]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.021   13.7   0.5      0.093   11.5   0.1    1.9  2  PTR2      POT family


Domain annotation for each model (and alignments):
>> PTR2  POT family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0     0.018   3.1e+02     306     336 ..     129     160 ..     124     198 .. 0.75
   2 ?   11.5   0.1   5.2e-06     0.093     102     124 ..     259     281 ..     243     316 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.018
                 HHCCHHHT-------.---TCCCHHHHHHHHH CS
        PTR2 306 kraktlpelpeaeev.qisvlwlipqylligi 336
                 +++k +p+l+ ++   qi+++++i ++l++ +
  EFC39277.1 129 FIKKSAPTLKRTQIKeQIRIWVQIASSLVVLL 160
                 56777777776665579*******99998765 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 5.2e-06
                 T-HHHHHHHHHHHHHHHHHHHHC CS
        PTR2 102 vgyplgFgipavlmiiallvFll 124
                  gy lgFgip+++++ia+++ + 
  EFC39277.1 259 LGYGLGFGIPGFIIFIAIIIIVS 281
                 79****************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (402 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1231  (0.0686597); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 2581.95
//
Query:       EFC39278.1  [L=261]
Description: hypothetical protein NAEGRDRAFT_59314 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.037   12.9   0.1      0.053   12.4   0.1    1.2  1  PTR2      POT family


Domain annotation for each model (and alignments):
>> PTR2  POT family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   2.9e-06     0.053     102     124 ..     115     137 ..      98     167 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.9e-06
                 T-HHHHHHHHHHHHHHHHHHHHC CS
        PTR2 102 vgyplgFgipavlmiiallvFll 124
                  gy lgFgip+++++ia+++ + 
  EFC39278.1 115 LGYGLGFGIPGFIIFIAIIIIVS 137
                 79****************98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (261 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1264  (0.0705003); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1538.72
//
Query:       EFC39279.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    7.3e-07   29.4   0.2    6.1e-06   26.4   0.2    2.1  1  SKI         Shikimate kinase
    1.6e-05   25.5   0.9    3.3e-05   24.4   0.9    1.5  1  AAA_18      AAA domain
      4e-05   23.6   0.0    6.3e-05   22.9   0.0    1.3  1  APS_kinase  Adenylylsulphate kinase
    0.00052   20.2   0.0     0.0011   19.2   0.0    1.5  1  AAA_33      AAA domain
    0.00056   19.3   0.0    0.00095   18.5   0.0    1.4  1  6PF2K       6-phosphofructo-2-kinase
     0.0047   17.4   0.1     0.0081   16.7   0.1    1.7  1  ABC_tran    ABC transporter
     0.0077   15.7   0.1      0.047   13.1   0.0    2.1  2  KTI12       Chromatin associated protein KTI12
  ------ inclusion threshold ------
      0.012   15.4   0.0      0.028   14.2   0.0    1.6  2  PRK         Phosphoribulokinase / Uridine kinase family
      0.023   14.0   0.0       0.18   11.1   0.0    2.0  2  Zeta_toxin  Zeta toxin
      0.026   14.9   0.0       0.06   13.7   0.0    1.3  1  AAA_16      AAA ATPase domain
      0.029   14.8   0.4       0.12   12.8   0.1    2.2  3  AAA         ATPase family associated with various cellular ac
      0.048   13.5   0.0        0.2   11.4   0.0    1.9  2  CPT         Chloramphenicol phosphotransferase-like protein
      0.059   13.2   0.2        0.2   11.5   0.2    1.9  1  dNK         Deoxynucleoside kinase
       0.47   10.9   3.0       0.93   10.0   3.0    1.7  1  AAA_23      AAA domain


Domain annotation for each model (and alignments):
>> SKI  Shikimate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.2   4.7e-09   6.1e-06       2     155 ..      53     237 ..      52     240 .. 0.80

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 4.7e-09
                 TSSHHHHHHHHHHHHT.....SEEEEHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHH.....HHHHCCCS..SEEEEE-TTGGGSHHHHHHHH..... CS
         SKI   2 GaGKstvGkllAkklg.....lefiDlDeliekrtgksiaeifeeegeegFrelEsev.....lkelleee..glViatGGGavlseenrellk..... 83 
                 G+GKst+G++l + l+     ++f++ D++++k +  ++a+ +  +  +++r+ +  +     ++e+ +++   +V++   +++l++ +rell      
  EFC39279.1  53 GCGKSTIGEALTQYLNecggeCCFLEGDKFHSKSNVEKMAKGIPLN--DQDRRPWLLAihlqiMNEIKHSNrkIVVVS---CSALKNIYRELLVlgdaq 146
                 9*************97666669*******************99976..889999976622221555555555334444...599*********999*** PP

                 ....................HHSEEEEEE--HHHHHHHHHHTTSSGGGCSCHHHHHHHHHHH.HHHHHHCCSSCEEEECTSSHHHHHHHHHHH CS
         SKI  84 ....................ekgiviyLdvsleellerlkadkeRPllqekskeeelleela.ereplyeeaadvvvdeseeskeevaeeile 155
                                      + +++ L +s +e ++rl++++   + +   +  ++ e+l+ + +p  ++a+ vvvd++e++ + v+++i++
  EFC39279.1 147 lceneeelldkpiqhnvnldINWLFVNLSISQNEAQDRLENRSAHFMNSSLIP--SQFETLElTINPTIKNAKLVVVDNQEKDVASVVQQIIQ 237
                 *************9888776666778888888889999999988544444444..6666666679**************************98 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.4   0.9   2.6e-08   3.3e-05       1     115 [.      46     190 ..      46     196 .. 0.74

  Alignments for each domain:
  == domain 1  score: 24.4 bits;  conditional E-value: 2.6e-08
      AAA_18   1 IlltGtpGvGKttlakeLskrl.gf..............gvnlrdvakenglllevdpe........aldeskrldedkldklldaleenss....... 69 
                 I+l G++G+GK+t++++L + l ++                n+ ++ak   l + +  +          +e k  +++ + +  +al+++++       
  EFC39279.1  46 IVLFGVCGCGKSTIGEALTQYLnECggeccflegdkfhsKSNVEKMAKGIPLNDQDRRPwllaihlqIMNEIKHSNRKIVVVSCSALKNIYRellvlgd 144
                 89****************888867799999999998876666666666655555555558877777777888888888888888888888877776666 PP

      AAA_18  70 .aleegknlvidghlaeleseaakdikkvvLtaspeelleRlekRgy 115
                   l e++  ++d  +++++  +   +  v L  s +e  +Rle+R+ 
  EFC39279.1 145 aQLCENEEELLDKPIQHNVNLDINWLF-VNLSISQNEAQDRLENRSA 190
                 644455555677666666655444333.****************985 PP

>> APS_kinase  Adenylylsulphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.0   4.9e-08   6.3e-05       3      61 ..      44     107 ..      42     138 .. 0.76

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 4.9e-08
                 EEEEEESSTTSSHHHHHHHHHHHHHHTT--EEEEEHHHHTT.....TTTTT--SSHHHHHHHHH CS
  APS_kinase   3 vvvwltGlsgsGKstianalekkLvekgisvylLdGdnvRh.....gLnkdLgfseedRkenir 61 
                 +v+ l G+ g GKsti +al ++L+e g ++  L+Gd+        ++ k+++ +++dR   + 
  EFC39279.1  44 LVIVLFGVCGCGKSTIGEALTQYLNECGGECCFLEGDKFHSksnveKMAKGIPLNDQDRRPWLL 107
                 689999*******************************987511111466777888888776555 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   0.0   8.4e-07    0.0011       1     121 [.      45     191 ..      45     208 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 8.4e-07
      AAA_33   1 lvllvGlpGsGKstlaerllkklg.....avllssdtlrrrlfg..tdqqsktdytrvldrlyqilnelarkalsagrnvildat.............. 78 
                 +++l G+ G+GKst  e l + l      +++l+ d+++++  +    +  + + ++ +++l +i  ++ ++   ++r +++ +               
  EFC39279.1  45 VIVLFGVCGCGKSTIGEALTQYLNecggeCCFLEGDKFHSKSNVekMAKGIPLNDQDRRPWLLAIHLQIMNEIKHSNRKIVVVSCsalkniyrellvlg 143
                 799**************9977777777**********99977663333334445566788899988899999888888877766555565555544444 PP

      AAA_33  79 ..nlsrrerarflklar...rlgvpvrivvvetdeetlkeRlakRaan 121
                    l ++e + ++k  +   +l+ + + v ++ ++ ++++Rl+ R+a+
  EFC39279.1 144 daQLCENEEELLDKPIQhnvNLDINWLFVNLSISQNEAQDRLENRSAH 191
                 442224444555555551113444455666777788888888888876 PP

>> 6PF2K  6-phosphofructo-2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   7.4e-07   0.00095      10      51 ..      40      80 ..      33     126 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 7.4e-07
                ..S-EEEEEESSTTSSHHHHHHHHHHHHHHTT--EEEEEHHH CS
       6PF2K 10 knsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgk 51
                +++ lvivl G    gK++i ++lt+yl+  g ++  F  g+
  EFC39279.1 40 DDKYLVIVLFGVCGCGKSTIGEALTQYLNECGGECC-FLEGD 80
                467799***********************9999984.44444 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.1   6.4e-06    0.0081      13      68 ..      45     104 ..      35     234 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 6.4e-06
                 EEEEEESTTSSHHHHHHHHTTSS--SEEEEEET.TCEGGG.B-HHHCCHCEEEE-SS..- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxx.xxxxxxxxxxxxxxxx..x RF
    ABC_tran  13 kvaivGenGaGKStLlkllagllkpteGeilld.gkdlke.qeleslrkeigvlpqe..p 68 
                 +++++G  G+GKSt+ ++l++ l+   Ge  +  g+++++  + e++ k i    q+  p
  EFC39279.1  45 VIVLFGVCGCGKSTIGEALTQYLNECGGECCFLeGDKFHSkSNVEKMAKGIPLNDQDrrP 104
                 57899********************99999655466666556777777777777777442 PP

>> KTI12  Chromatin associated protein KTI12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   0.0   3.6e-05     0.047       4      50 ..      46      91 ..      44     103 .. 0.86
   2 ?    0.2   0.1      0.31     4e+02      88     113 ..     112     137 ..     108     237 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 3.6e-05
                EEEE--TTSSHHHHHHHHHHHHHHTT--EEEE-THHHH.TTSSS--G CS
       KTI12  4 vvltGlPssGKstrakeLakaleeekrsvvviddeslgiekdsykds 50
                +vl+G+   GKst+ + L ++l+e + ++  ++ ++++ +k++++++
  EFC39279.1 46 IVLFGVCGCGKSTIGEALTQYLNECGGECCFLEGDKFH-SKSNVEKM 91
                899*****************************999999.55555555 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.31
                 HHHHHHHHTT-EEEEEEEE--HHHHH CS
       KTI12  88 eLyciakaakttlcvvyvvapldvlv 113
                 +++++ k+++ + +vv++ a ++  +
  EFC39279.1 112 QIMNEIKHSNRKIVVVSCSALKNIYR 137
                 66777777777777777776644443 PP

>> PRK  Phosphoribulokinase / Uridine kinase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   2.2e-05     0.028       1      48 [.      45      92 ..      45     103 .. 0.90
   2 ?   -2.8   0.0       3.4   4.4e+03     176     195 ..     208     227 ..     196     229 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.2e-05
         PRK  1 vIgvagsSGaGkttvarklekifgrekvkaaeiegdsflrldraekdl 48
                vI + g  G+Gk+t+ ++l++ +++ + +    egd+f++  ++ek +
  EFC39279.1 45 VIVLFGVCGCGKSTIGEALTQYLNECGGECCFLEGDKFHSKSNVEKMA 92
                6888999**********************9999*******99988765 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.4
         PRK 176 yikpqfseadliiqrvptvd 195
                  i+p++++a l++   +++d
  EFC39279.1 208 TINPTIKNAKLVVVDNQEKD 227
                 47888888888876666655 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00014      0.18      11      55 ..      38      83 ..      29      94 .. 0.84
   2 ?    0.4   0.0      0.27   3.4e+02     125     186 ..     166     222 ..     148     233 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00014
  Zeta_toxin 11 psqerPklillgGqpGAGKselaellkdele.rqgnvvrldpDdlR 55
                +++++  +i+l G  G+GKs++ e+l+++l+  +g++  l++D++ 
  EFC39279.1 38 VNDDKYLVIVLFGVCGCGKSTIGEALTQYLNeCGGECCFLEGDKFH 83
                55677789999*******************9889999999999986 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.27
  Zeta_toxin 125 evvvvavkkelSrlgvldRyeeevaegRlvpkeehdeafeglresvealeeekqldrvkikd 186
                  +  + v+  +S+ +++dR e+++a   +++ + +  +fe l+ +++   ++    +++++d
  EFC39279.1 166 DINWLFVNLSISQNEAQDRLENRSA--HFMNSSLIPSQFETLELTINPTIKNA---KLVVVD 222
                 5666778888999999999999944..47787777788887777777533333...233444 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   4.7e-05      0.06      17      76 ..      36     109 ..      28     124 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 4.7e-05
      AAA_16  17 ervrsgrpelvllsGesGvGKsslvrellralekd..ggiflrgkcdqlesa.......ipy.....salaqal 76 
                 erv+++   +++l G  G+GKs++ ++l ++l++   ++ fl+g+  +++s+       ip+      +++ a+
  EFC39279.1  36 ERVNDDKYLVIVLFGVCGCGKSTIGEALTQYLNECggECCFLEGDKFHSKSNvekmakgIPLndqdrRPWLLAI 109
                 6888888899*******************988888433555777776665555555555555555544455555 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.1   9.6e-05      0.12       1      37 [.      46      85 ..      46     127 .. 0.79
   2 ?   -0.6   0.0       1.3   1.7e+03      90     117 ..     111     137 ..      87     146 .. 0.66
   3 ?   -3.1   0.0       7.6   9.7e+03      31      52 ..     215     234 ..     202     238 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 9.6e-05
                EEEESSTTSSHHHHHHHHHHHH...THEEEEEETTTCSSS CS
         AAA  1 vllyGppGtGKTllakavakel...gvefleisgsellsk 37
                ++l+G  G+GK+++ +a+ + l   g e++ ++g ++ sk
  EFC39279.1 46 IVLFGVCGCGKSTIGEALTQYLnecGGECCFLEGDKFHSK 85
                579****************997333588888888888855 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.3
                 HHHHHHTTTSSSTEEEEEEESSGGGSTH CS
         AAA  90 lteldgvkkkeskvivigatnrpdkldp 117
                 l+ +++ k++++k iv++ +   +++ +
  EFC39279.1 111 LQIMNEIKHSNRK-IVVVSCSALKNIYR 137
                 5566666666554.44444444444444 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 7.6
                 TTTCSSSSTTHHHHHHHHHHHH CS
         AAA  31 gsellskyvgesekkirelfke 52 
                  ++l+  +v ++ek+++ ++++
  EFC39279.1 215 NAKLV--VVDNQEKDVASVVQQ 234
                 44444..667777777777766 PP

>> CPT  Chloramphenicol phosphotransferase-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00016       0.2       3      52 ..      45      97 ..      44     193 .. 0.73
   2 ?    0.6   0.0      0.36   4.6e+02      32      91 ..     165     224 ..     142     239 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00016
                EEEEEE-TTSSHHHHHHHHHHHSSS-...EEEEEHHHHHHHS-GGGGTSTTSE CS
         CPT  3 iilLnGgsssGKsslaralqevldep...wlhlgvDafvealppkrqdeadgl 52
                +i+L G+   GKs++ +al + l+e+      l+ D+f+ +   +++++++ l
  EFC39279.1 45 VIVLFGVCGCGKSTIGEALTQYLNECggeCCFLEGDKFHSKSNVEKMAKGIPL 97
                89********************9998333355677777777666666655555 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.36
                 EEHHHHHHHS-GGGGTSTTSEEEETTSEEE-HHHHHHHHHHHHHHHHHHHTT-EEEEEE- CS
         CPT  32 lgvDafvealppkrqdeadglefeteleeigpeldlllaalyeavaamaraGnnvivDdv 91 
                 l +  ++  l  ++ +++d le  + +     +++  +++l  +++   ++ + v+vD+ 
  EFC39279.1 165 LDINWLFVNLSISQNEAQDRLENRSAHFMNSSLIPSQFETLELTINPTIKNAKLVVVDNQ 224
                 444445555777888888888888888888888999999999999999999999999943 PP

>> dNK  Deoxynucleoside kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.2   0.00016       0.2       1     148 [.      46     193 ..      46     237 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00016
                 EEEEESTTSSHHHHHHHHHCCSTCEEEE-....HHHHCCSSSS.....HHHHHHHHSHHHHHHHHHHHHHHHHHHHHHCHHSSS-EEEEES-HHHHHHT CS
         dNK   1 ivveGnIgaGKstlvklLskklgvkvfeE....pvdkwtnvqk.....nlLekfYkdpsrwsfalqtyvllsrlkqqlealatkqvvvleRsiysdryi 90 
                 iv+ G  g+GKst+ + L++ l+ ++  E    + dk+  + +     + +++  +d   w +a+  +++++  ++  +      +vv+  s  ++ y 
  EFC39279.1  46 IVLFGVCGCGKSTIGEALTQYLN-ECGGEccflEGDKFHSKSNvekmaKGIPLNDQDRRPWLLAIHLQIMNEIKHSNRK------IVVVSCSALKNIYR 137
                 788899************99985.3333333334455533222444668888888888889888888888776555533......45555555554433 PP

                 HHHHHHHTTSS-HHHHHHHHHHHHHHHHHCCH-SEEEEEE--HHHHHHHHHHCTTCCC CS
         dNK  91 FakalaekgtlseeelkiykelldnlleelakpdlliYLkasletclerikkRgreee 148
                    +l + +  ++ee    k + +n++ +++   l++ L +s ++   r+++R+ ++ 
  EFC39279.1 138 ELLVLGDAQLCENEEELLDKPIQHNVNLDIN--WLFVNLSISQNEAQDRLENRSAHFM 193
                 3355666777777777677778888887777..7888888888888888888887764 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   3.0   0.00073      0.93      21      49 ..      45      73 ..      20     241 .] 0.58

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00073
      AAA_23 21 ltlItGpNGaGKTTildAiklaLygetpr 49
                + +++G  G+GK+Ti +A++  L +  ++
  EFC39279.1 45 VIVLFGVCGCGKSTIGEALTQYLNECGGE 73
                56999***************988764433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       820  (0.045736); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 1626.13
//
Query:       EFC39280.1  [L=503]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-16   57.5   1.4      2e-15   56.5   1.4    1.4  1  YdjM      LexA-binding, inner membrane-associated putative hy
  ------ inclusion threshold ------
      0.051   11.9   0.2      0.089   11.1   0.2    1.3  1  PAT1      Topoisomerase II-associated protein PAT1


Domain annotation for each model (and alignments):
>> YdjM  LexA-binding, inner membrane-associated putative hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.5   1.4   2.2e-19     2e-15      26     169 ..     119     356 ..     105     361 .. 0.75

  Alignments for each domain:
  == domain 1  score: 56.5 bits;  conditional E-value: 2.2e-19
        YdjM  26 eavllavavlgAllPDiDhpsstlgrklgllskklak.............................................................. 62 
                 e+ +++v+++ A+lPD+D+  ++++  l  +++ +++                                                              
  EFC39280.1 119 EQKYYVVGMILANLPDVDIALFIISFFLSFFKG-FSRmidrihrlwelfisltnkkqeessgggmtssfsssslnaaqtpagsssnlsqydsdsedtqp 216
                 4678999***********777777666666665.5556788********************************************************** PP

        YdjM  63 ....................lvgHRgftHSllflallalvlllllrlfgrsa.....lrlglllllgvlsHlllDlltkyGvpllwPfskkkvrlsllf 136
                                     l+ +R+++HSl+  +ll+ ++ + ++++   +      + ++l ++ + sHlllD +t+ G+ ll+P+s+    l+++ 
  EFC39280.1 217 tvtnarrnwkamlerrdknsLTFRRTISHSLPINLLLSPLIGFGVQKVLGLHgfnsfTHCTTLSACCLSSHLLLDFMTNFGTALLYPISS---ELYSFG 312
                 ********************999*********97777766666666666555454433333334444666******************76...444444 PP

        YdjM 137 iiidplltll.............srrglvalelvllvly.lviilva 169
                 i ++  +tl              +   +   ++++++l+ l++i+++
  EFC39280.1 313 IVTSWDFTLIvffyswltasrlnR---WKQSNVFWIGLFcLGLIFIW 356
                 433333444466777777776541...33333333333314444444 PP

>> PAT1  Topoisomerase II-associated protein PAT1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2   9.9e-06     0.089     624     670 ..      89     137 ..      79     140 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 9.9e-06
        PAT1 624 ttvhPFiallsfp..KGkkaipRifrhlskeqrvtiLtmivvhlDqLdv 670
                 t  + F  +ls +  K  + i R f hl++eq+  ++ mi+ +l  +d+
  EFC39280.1  89 TSLKQFFKVLSTNmfKFLRRIKRFFSHLTFEQKYYVVGMILANLPDVDI 137
                 55667888888763477799************************99998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (503 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       974  (0.0543254); expected 358.6 (0.02)
Passed bias filter:                      518  (0.0288917); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 2838.76
//
Query:       EFC39281.1  [L=335]
Description: sjogren syndrome antigen B-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-27   93.8   0.2    9.1e-27   92.9   0.2    1.5  1  La        La domain
    6.5e-08   32.3   1.1      1e-06   28.4   0.2    2.9  3  RRM_1     RNA recognition motif. (a.k.a. RRM, RBD, or RNP dom
  ------ inclusion threshold ------
       0.12   12.6   0.1        1.5    9.1   0.0    2.5  2  DUF3993   Protein of unknown function (DUF3993)


Domain annotation for each model (and alignments):
>> La  La domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.9   0.2   1.5e-30   9.1e-27       1      59 []      11      69 ..      11      69 .. 0.98

  Alignments for each domain:
  == domain 1  score: 92.9 bits;  conditional E-value: 1.5e-30
                HHHHHHHHHHTT-TTT-HHHHHHHTTSTTS---HHHHHTSSHHHHHHSSHHHHHHHHHT CS
          La  1 ilkQvEfYFSdeNLpkDkFLrkkmdkdpegwVplsliasfkrmkkltkdveliaealre 59
                i++QvEfYFSd+NLpkDkFLr+++ ++peg+V+l++iasf+rmk++++d++li++al++
  EFC39281.1 11 IREQVEFYFSDSNLPKDKFLRSLVANNPEGYVELKTIASFNRMKQISTDMDLIVSALKK 69
                899******************************************************85 PP

>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       1.3   7.7e+03      38      55 ..      36      53 ..      33      55 .. 0.76
   2 !   28.4   0.2   1.8e-10     1e-06      11      52 ..     112     153 ..     106     165 .. 0.92
   3 ?    1.0   0.0     0.064   3.8e+02      30      65 ..     234     266 ..     224     269 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 1.3
                EEEEEEEEESSHHHHHHH CS
       RRM_1 38 skgfafVeFeskedAekA 55
                +++ ++Ve ++  + ++ 
  EFC39281.1 36 NNPEGYVELKTIASFNRM 53
                577899999998887765 PP

  == domain 2  score: 28.4 bits;  conditional E-value: 1.8e-10
                 SHHHHHHHHHTTSCEEEEEEEEETTTSEEEEEEEEESSHHHH CS
       RRM_1  11 teeeLkelFskfGpiksiklvrdetgkskgfafVeFeskedA 52 
                 + + +k+lF++fG+++ ++  r+++g+ kg af+eF+s++  
  EFC39281.1 112 NLDSIKALFEPFGKVVCVRARREKNGTFKGSAFIEFDSESTV 153
                 6789**********************************9865 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.064
                 EEEETTTSEEEEEEEEESSHHHHHHHHHHHTTEEET CS
       RRM_1  30 lvrdetgkskgfafVeFeskedAekAlealngkklg 65 
                 l++   +k++g  f++F+   d +kA+ +l  k++ 
  EFC39281.1 234 LPY---NKKNGLKFIDFPLDGDKTKAILRLESKEVF 266
                 444...5899999*****999999**9999998875 PP

>> DUF3993  Protein of unknown function (DUF3993)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.16   9.5e+02      45      67 ..       2      24 ..       1      46 [. 0.79
   2 ?    9.1   0.0   0.00024       1.5      12      77 ..     247     313 ..     243     319 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.16
     DUF3993 45 sekersleemievLePYftdafa 67
                s+ e + +++ e +e Yf d+ +
  EFC39281.1  2 SDAEITSNKIREQVEFYFSDSNL 24
                56788999**********99876 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00024
     DUF3993  12 fsvdtvkageeaevdRkevletlqsaye.aqfslsekersleemievLePYftdafasvfveenase 77 
                 f +d  k+++    + kev++ l++ ++  +++l +k  + e   e Le Y+ ++   +f e n  +
  EFC39281.1 247 FPLDGDKTKAILRLESKEVFDSLKQQFDeGKIELPGKAVASEMAPEDLEKYIAKTCEAKFAESNKNK 313
                 5566666777777789*******99996269***********99******************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (335 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2651  (0.147861); expected 358.6 (0.02)
Passed bias filter:                     1031  (0.0575046); expected 358.6 (0.02)
Passed Vit filter:                       111  (0.00619109); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.35s 00:00:01.10 Elapsed: 00:00:00.55
# Mc/sec: 1848.23
//
Query:       EFC39282.1  [L=383]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (383 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1487  (0.0829383); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.37s 00:00:01.06 Elapsed: 00:00:00.56
# Mc/sec: 2068.39
//
Query:       EFC39283.1  [L=326]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-36  124.9  14.2    1.9e-35  122.7  14.2    1.8  1  G-alpha   G-protein alpha subunit
  ------ inclusion threshold ------
      0.045   12.8   0.0      0.065   12.3   0.0    1.2  1  T2SSE     Type II/IV secretion system protein


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  122.7  14.2   2.1e-39   1.9e-35       3     321 ..      10     296 ..       8     316 .. 0.85

  Alignments for each domain:
  == domain 1  score: 122.7 bits;  conditional E-value: 2.1e-39
                 XXXXXXXXXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS--..--HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SC CS
     G-alpha   3 tssaidkslkaerkarkkkrevkllllGqseSGKsTilkqlkllykkg..fseeelatwraviqlnivrsiktilealesleselsesfelqelkerld 99 
                 +s+aid+ l++  +  kk    ++l+lG+ +SGKsT+   +  l k++  +++ e ++    i++ ++r+++   ++++    +    f+ ++l+e+++
  EFC39283.1  10 HSQAIDTALRRRITPCKK----QILILGACSSGKSTFRHGIYHLSKETnsMMNAEERE--LHIRKYVIRCLDICWQTFKIV--D----FKFSNLNEEIK 96 
                 689***************....********************9998876666665555..589******999999999884..3....36688888888 PP

                 CCS-HCHHHH..........HHCCHHC.-HCHHHHHHHHCCSHHHHHHHC.CGCCTT--TTHHHHHCT..HHHHCSTT----CHHHHCS-----SEEEE CS
     G-alpha 100 plkkveasliaklssateeeqeiefnp.raevgedikaLwndpgiqelye.rrnkiklednaeyFldd..leritspdYlptddDilkarlktvGiset 194
                 + +                 ++ +f++  +e+ +++ +L +++     +e  +++++ ++n++yF+++  + ++++ +   t +D+l+++++ +  s +
  EFC39283.1  97 KAR-----------------KSGVFTSsMIEFMKYLTMLKSEE-----LEfISHHFRYMENIRYFFSEnfIAKLQAINADFTIHDLLQTKIPHSKSSIY 173
                 877.................44566661334444555555444.....44233579999********88***********************9999999 PP

                 EEECT-TEEEEEEEE-SSHHHHHGTCCCT.TTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GG CS
     G-alpha 195 kfevdsklefrivdvgGqrserkkWvpff.ddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgkls 292
                 +f+++   + +++d   qr+e++kW+++f + ++ +i+l+sl++++ + + +   n l  +l+ F+e++n +++  +++ ++++KlD+++eKl+k ++s
  EFC39283.1 174 EFSFE---TSKLIDPSPQRNEKRKWISHFdNTMTRVIYLISLADYNLTDSISG-ANCLWLALQNFSEFVNYSEYIPADVSIVFTKLDLFKEKLEKYPFS 268
                 99998...5579*****************677899**********99888855.********************************************* PP

                 GCCTT--H.CCHHHHHHHHHHHHHHCCCC CS
     G-alpha 293 kyfpsyegrkndlesvlkylrnkFeeihk 321
                 +yf++y+g +nd e+ l++l ++ +++ +
  EFC39283.1 269 DYFTEYTG-PNDSETILTFLLSQNTDLTQ 296
                 *******9.************99988854 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   7.2e-06     0.065     112     164 ..       8      60 ..       1      72 [. 0.72

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 7.2e-06
       T2SSE 112 ealkekiaevlrkavr.erglilvsGgTgsGKttllyallkeinksderivtvE 164
                 +  +++i+ +lr+ ++  ++ il+ G+ +sGK+t+   + +  +++ + ++ +E
  EFC39283.1   8 KLHSQAIDTALRRRITpCKKQILILGACSSGKSTFRHGIYHLSKET-NSMMNAE 60 
                 445577788888777635899*************987776665555.6666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (326 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       812  (0.0452898); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.22s 00:00:00.73 Elapsed: 00:00:00.39
# Mc/sec: 2489.07
//
Query:       EFC39284.1  [L=387]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.024   13.9   0.2      0.041   13.2   0.2    1.3  1  DUF3450   Protein of unknown function (DUF3450)


Domain annotation for each model (and alignments):
>> DUF3450  Protein of unknown function (DUF3450)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.2   2.3e-06     0.041     125     169 ..      39      83 ..      34      89 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.3e-06
     DUF3450 125 qarlakLkelmdradvslaekyrrvleayqiEaeYgrtievyqge 169
                 + ++a+L++l++r+++ ++  yr+++e+ +i   Yg ti+  q e
  EFC39284.1  39 TLKMANLQKLIERTEMGVNSEYRNIVELNNIFSTYGFTIDFNQME 83 
                 5679************************************99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (387 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       660  (0.0368119); expected 358.6 (0.02)
Passed bias filter:                      349  (0.0194657); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.22s 00:00:00.71 Elapsed: 00:00:00.41
# Mc/sec: 2827.26
//
Query:       EFC39285.1  [L=874]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.2e-36  124.1   1.8    8.8e-17   61.6   0.2    2.8  2  UvrD-helicase    UvrD/REP helicase N-terminal domain
    1.8e-26   93.4   0.5    3.9e-15   56.1   0.0    3.2  3  UvrD_C           UvrD-like helicase C-terminal domain
    1.8e-26   93.2   0.0      3e-24   86.0   0.0    2.5  2  AAA_19           AAA domain
      3e-15   55.8   0.0    6.4e-15   54.7   0.0    1.6  1  UvrD_C_2         UvrD-like helicase C-terminal domain
    1.7e-10   40.9   0.0    3.6e-10   39.9   0.0    1.5  1  AAA_30           AAA domain
    3.8e-10   39.9   1.0      3e-05   23.9   0.1    3.8  3  Viral_helicase1  Viral (Superfamily 1) RNA helicase
    3.2e-07   30.2   3.7    1.1e-05   25.2   0.0    3.8  4  AAA_12           AAA domain
     0.0025   17.6   0.2      0.011   15.6   0.0    2.1  2  DEAD             DEAD/DEAH box helicase
     0.0038   17.3   1.0      0.019   15.0   1.0    2.3  1  AAA_14           AAA domain
  ------ inclusion threshold ------
       0.19   12.0   1.7        2.7    8.3   1.0    2.8  2  AAA_22           AAA domain
        2.9    7.9   7.3        7.6    6.5   0.0    3.3  3  ResIII           Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> UvrD-helicase  UvrD/REP helicase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.9   0.1   8.7e-20   1.4e-16       2     111 ..     100     192 ..      99     200 .. 0.91
   2 !   61.6   0.2   5.4e-20   8.8e-17     239     314 ..     206     281 ..     200     282 .. 0.94

  Alignments for each domain:
  == domain 1  score: 60.9 bits;  conditional E-value: 8.7e-20
                    SHHHHHHHHS.-SSEEEEEE-TTSSHHHHHHHHHHHHHHTSSSTGGGEEEEESSHHHHHHHHHHHHHHHHHCCHHCTT-HHHHHHHHHCTTSEEEE CS
  UvrD-helicase   2 npeqreaias.lggpilveAsAGsGKTfvlaerilrlikeeeiepdrilvvTFTnkAaeElkeRieealkkaeqessdderlrlalqnlseanisT 96 
                    ++eq++ +   ++ ++lv+A AGsGKT++++ +i+++ik  +i +++i++ TF + Aa+ +ke+++++  k                  s+ +i+T
     EFC39285.1 100 SEEQKQVVFGdVNDDLLVLACAGSGKTTTIICKIVYMIKYLKIPAHQIMLTTFSRLAANDMKEKLASIGVK------------------SKFTIGT 177
                    678888888889*******************************************************8665..................589**** PP

                    HHHHHHHHHHHHHGG CS
  UvrD-helicase  97 lHsfcqkilkkeanr 111
                    +++f++k+lkk+ + 
     EFC39285.1 178 IDAFAYKTLKKYWQY 192
                    ***********9775 PP

  == domain 2  score: 61.6 bits;  conditional E-value: 5.4e-20
                    HHHHHHHCHHHHHHHHHHSSEEEESSGGG-BHHHHHHHHHHHTTTTTEEEEE-GGG--GGGGTB-THHHHHHHHHS CS
  UvrD-helicase 239 llelleeneelaealrerykeiliDEyQDTnkiQyrilkllasgheelfmvGDpkQsIYgFRgAdielflkkkkdf 314
                    l +l+++ +e+a+++ ++ k++ iDEyQD ++ Q++i++   ++  +++ vGD+ Q IY++Rg+ +e +l++ +++
     EFC39285.1 206 LRNLMKNYPEIADEICKKKKYLIIDEYQDIDNFQAEIFEEFHKRGCKIIAVGDDSQNIYSWRGSSVEHILNFHSKY 281
                    55788899****************************************************************9987 PP

>> UvrD_C  UvrD-like helicase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.3   0.1   9.9e-12   1.6e-08       2     103 ..     288     384 ..     287     388 .. 0.78
   2 !   56.1   0.0   2.4e-18   3.9e-15     272     346 ..     389     455 ..     383     458 .. 0.82
   3 ?   -1.5   0.0       0.8   1.3e+03     202     219 ..     718     735 ..     519     797 .. 0.63

  Alignments for each domain:
  == domain 1  score: 34.3 bits;  conditional E-value: 9.9e-12
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      UvrD_C   2 vLekNyRStksLlkaankflenilnrralekek.ktvekgekivvleaeteeeEaekiaatikallekneklediavLvRsnkdadkiskaLkkegipf 99 
                 +L++NyRSt+++l++an++l+n+ +++ +e    +t+e++ k ++ + ++    a+ki + +k+ +     +e+ia+L  +n+   k++++L+k  ip+
  EFC39285.1 288 TLTRNYRSTPEILQVANAILRNNPDNIPKE--MtTTRESNLKPIIVNDNQGLYVAKKISEYLKRGV----PRERIAILSPTNYGLYKVEEQLSKFFIPH 380
                 699*****************9998883332..2244555557777766666666666666666666....***************************** PP

                 xxxx RF
      UvrD_C 100 nvvd 103
                 +++ 
  EFC39285.1 381 ITIM 384
                 9875 PP

  == domain 2  score: 56.1 bits;  conditional E-value: 2.4e-18
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      UvrD_C 272 tLseseleeskkkekipiiTiHqAKGlEFdvVflagleegtfPsyrskkekrleEEkRlfYVaiTRAkkrLfisy 346
                 +L+e+e +  ++  k+ ++TiH++KGlE+d+Vfl++ ++++       k ++ +E +R++YVa+TRAk++L i +
  EFC39285.1 389 SLKEMERH--TTTGKVCLSTIHKSKGLEWDIVFLVDSSNDKW------KGDNDAELRRVLYVAVTRAKDELHIVL 455
                 45555553..3349**********************877765......588999*****************9975 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.8
                 xxxxxxxxxxxxxxxxxx RF
      UvrD_C 202 erqalvskyadlfkelae 219
                   + +  +y +lf++l+e
  EFC39285.1 718 FIKDIAPNYTELFNNLQE 735
                 223333334444444433 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.0   0.0   1.9e-27     3e-24       2     144 ..     104     265 ..     103     267 .. 0.81
   2 ?    4.6   0.0     0.024        39      30      80 ..     342     415 ..     337     480 .. 0.71

  Alignments for each domain:
  == domain 1  score: 86.0 bits;  conditional E-value: 1.9e-27
      AAA_19   2 reavealkekvllvtaGpGtGKTrvlkhivallvelggvkpeeillvaftgrAakelrerlaalgae....atTiHrlal................ldf 80 
                 ++ v+   ++ llv+a +G+GKT+++ +++ ++++  ++++++i+l +f + Aa+ ++e+la++g++    + Ti ++a                 +++
  EFC39285.1 104 KQVVFGDVNDDLLVLACAGSGKTTTIICKIVYMIKYLKIPAHQIMLTTFSRLAANDMKEKLASIGVKskftIGTIDAFAYktlkkywqyfdsqacvIEY 202
                 5566655567789****************************************************9999998899999888888888776666666333 PP

      AAA_19  81 ddlltealelle......eaeeekklqeeellivDEfqdvdelqyrLlkallgekkklllvGDpdQliyv 144
                   +l       +       +  ++  +++++li+DE+qd+d  q +++++  +++ k+++vGD+ Q+iy+
  EFC39285.1 203 GYRL-------RnlmknyPEIADEICKKKKYLIIDEYQDIDNFQAEIFEEFHKRGCKIIAVGDDSQNIYS 265
                 3222.......1333353223445555555**********************99999************8 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.024
      AAA_19  30 ivallvelggvkpeeillvaftgrAakelrerlaalgae........................atTiHrlalldf 80 
                 ++++++++g v+ e+i+++++t+    +++e+l+++  +                         +TiH+   l++
  EFC39285.1 342 KISEYLKRG-VPRERIAILSPTNYGLYKVEEQLSKFFIPhitimekskslkemerhtttgkvcLSTIHKSKGLEW 415
                 555666665.7889999**************99999999555555555555555555555555555555433332 PP

>> UvrD_C_2  UvrD-like helicase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.7   0.0   3.9e-18   6.4e-15       2      52 .]     402     454 ..     401     454 .. 0.91

  Alignments for each domain:
  == domain 1  score: 54.7 bits;  conditional E-value: 3.9e-18
    UvrD_C_2   2 ayaltihkaQGsefpaVivfdpd..laaarmgelrrrlLYtavTRAreklilv 52 
                 ++ +tihk++G+e+++V+++d +   +  +++++ rr LY+avTRA+++l++v
  EFC39285.1 402 VCLSTIHKSKGLEWDIVFLVDSSndKWKGDNDAELRRVLYVAVTRAKDELHIV 454
                 6789****************98755888888889****************998 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.9   0.0   2.2e-13   3.6e-10       2     175 ..      99     312 ..      98     324 .. 0.75

  Alignments for each domain:
  == domain 1  score: 39.9 bits;  conditional E-value: 2.2e-13
      AAA_30   2 lnaeQaaavealltsgdrvavltGpAGtGKttal.kalreaweaag...grviglAptgkaAkvLaeelg...i....eastiakllkrlk........ 81 
                 l++eQ+++v   ++++    ++ + AG+GKtt++  +++ +++  +   +++++ + +  aA++++e+l    +    +  ti+ + +++         
  EFC39285.1  99 LSEEQKQVVFGDVNDD---LLVLACAGSGKTTTIiCKIVYMIKYLKipaHQIMLTTFSRLAANDMKEKLAsigVkskfTIGTIDAFAYKTLkkywqyfd 194
                 7888888886655555...68889******98762566777777667779****************855433333333555666655544467777888 PP

      AAA_30  82 ......................grarlepgtllivDEagmvdtkqlaallkaaekagakvilvGDerQlasVeaGgvlrdlvea....agigtaeLtev 154
                                       + + +++++ li+DE   +d+ q++ ++++ +k+g k+i vGD+ Q     +G+ ++++++      + +  +Lt +
  EFC39285.1 195 sqacvieygyrlrnlmknypeiADEICKKKKYLIIDEYQDIDNFQAE-IFEEFHKRGCKIIAVGDDSQNIYSWRGSSVEHILNFhskyPNSKLLTLTRN 292
                 ********************9944566777**************975.77888888*************999999999999875322223355566666 PP

      AAA_30 155 vRqkeseeraaalalregdae 175
                 +R   +e+ ++a+a+ +++++
  EFC39285.1 293 YRS-TPEILQVANAILRNNPD 312
                 665.47888888888776665 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0     0.008        13       2      16 ..     116     130 ..     115     156 .. 0.88
   2 !   23.9   0.1   1.8e-08     3e-05     158     233 ..     367     454 ..     214     455 .. 0.58
   3 ?   -2.5   0.0       2.2   3.6e+03     128     155 ..     731     760 ..     728     789 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.008
  Viral_helicase1   2 vvhGvpGcGKStlir 16 
                      +v +++G+GK+t i 
       EFC39285.1 116 LVLACAGSGKTTTII 130
                      7999********885 PP

  == domain 2  score: 23.9 bits;  conditional E-value: 1.8e-08
  Viral_helicase1 158 tepkgq.e....kvlvyltftqalkealgvr.....evttvhevqGltfdkVtlvllketdlelis..esrenllvAlTRhrkslvil 233
                      ++ ++q +    + +++ + +++lke  +++       +t h   Gl++d V lv +++ + +  +  e r +l+vA TR++++l+i+
       EFC39285.1 367 YKVEEQlSkffiPHITIMEKSKSLKEMERHTttgkvCLSTIHKSKGLEWDIVFLVDSSNDKWKGDNdaELRRVLYVAVTRAKDELHIV 454
                      233333223445667777777777664444488888789****************998877665556566899*************96 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 2.2
  Viral_helicase1 128 yllpsdvaeilsakvgteveversgel..k 155
                      + l+++++++  +k++++v+++rs ++   
       EFC39285.1 731 NNLQEHFVPFIVEKTESSVNTHRSLSYgkH 760
                      568899999999998899999999888531 PP

>> AAA_12  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.67   1.1e+03      94     151 ..     129     181 ..      73     182 .. 0.78
   2 ?    3.1   0.0     0.039        63      14      36 ..     283     305 ..     269     311 .. 0.80
   3 !   25.2   0.0   6.7e-09   1.1e-05      79     195 ..     321     454 ..     311     457 .. 0.78
   4 ?   -1.9   0.0       1.3   2.2e+03      85     121 ..     780     817 ..     734     823 .. 0.76

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.67
      AAA_12  94 lvvklvekllkkgseeerkkigvitpYraqvellkkklkekeeeksekeievntvdgf 151
                 +++k+v  +    +    ++i   t+ r  ++ +k+kl++   ++   +++++t+d+f
  EFC39285.1 129 IICKIVYMIK-YLKIP-AHQIMLTTFSRLAANDMKEKLASIGVKS---KFTIGTIDAF 181
                 4555554444.44444.4889888888889999999999655543...4999999998 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.039
      AAA_12  14 kekvvlLdtqYRmhpeIsrfpsk 36 
                 ++k  +L+ +YR+ peI++ ++ 
  EFC39285.1 283 NSKLLTLTRNYRSTPEILQVANA 305
                 678899************99886 PP

  == domain 3  score: 25.2 bits;  conditional E-value: 6.7e-09
      AAA_12  79 kekke..ksyiNeeEaelvvklvekllkkgseeerkkigvitpYraqvellkkklke...............keeekseke.........ievntvdgf 151
                 +++++    ++N++    v+k ++++lk+g+ +  ++i++++p +  +  ++++l++               k       e         +  +t+ + 
  EFC39285.1 321 TRESNlkPIIVNDNQGLYVAKKISEYLKRGVPR--ERIAILSPTNYGLYKVEEQLSKffiphitimekskslK-------EmerhtttgkVCLSTIHKS 410
                 3333344789999******************99..9********************86666666655443331.......1455667777********* PP

      AAA_12 152 QGrekdviilslVRsnekkeigflkderrlNValTRAkskliiv 195
                  G e+d+++l    + + k     + +r l Va+TRAk++l iv
  EFC39285.1 411 KGLEWDIVFLVDSSNDKWKGDNDAELRRVLYVAVTRAKDELHIV 454
                 ********9977666544444455678889***********998 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 1.3
      AAA_12  85 syiNeeEaelvvklvekllkkgsee.erkkigvitpYr 121
                 s++ + E+e +++l+ +   +  +  e k+igvi p r
  EFC39285.1 780 SVSQDIEVEWIIQLLCYAAMARLDGmEIKNIGVINPLR 817
                 66677788888887755444433334789999998865 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0   6.5e-06     0.011      14     145 ..     112     246 ..     100     263 .. 0.66
   2 ?   -2.3   0.0         2   3.2e+03      42      78 ..     346     385 ..     336     411 .. 0.63

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 6.5e-06
                 TCEEEEEESTTSSHHHHHHHHHHHHHHHSTTSTS-EEEEEESSHHHHHHHHHHHHHHTTTSTSEEEEE..ETTSSHHHHHHHHHTTCSEEEEEHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  14 ggdvlvaaeTGsGKTlaflipvlqivyetkgktgpkalivePtreLaeqtlnnlkkfkkyidlrvlli..iggvaardqlskldngvdivvgtpgrldd 110
                 ++d+lv a  GsGKT+  +  ++  +    + ++ ++++ + +r  a+++ ++l +++ + + ++  i  +  ++ ++ ++ +  +  +v+    rl +
  EFC39285.1 112 NDDLLVLACAGSGKTTTIICKIVYMIKY-LKIPAHQIMLTTFSRLAANDMKEKLASIGVKSKFTIGTIdaFAYKTLKKYWQYF-DSQACVIEYGYRLRN 208
                 5799****************99988844.455555666666667777778888877777544333222113344444455555.456777777788999 PP

                 HH....HCTSSH...CTTEEEEEEETHHHHHHTTTHHHHHHH CS
                 xx....xxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD 111 ll....stgkln...lsqvrflVlDEadrlldqgfsdfinri 145
                 l+    +   +    +++ ++l++DE + + +  + +  ++ 
  EFC39285.1 209 LMknypE---IAdeiCKKKKYLIIDEYQDIDNF-QAEIFEEF 246
                 8865441...334559**********8877665.33444444 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 2
                 S..TTSTS-EEEEEESSHHHHHHHHHHHHHHTTT.STSEE CS
                 x..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxx RF
        DEAD  42 t..kgktgpkalivePtreLaeqtlnnlkkfkky.idlrv 78 
                    +g ++ ++ i++Pt     ++ ++l+kf+ + i++ +
  EFC39285.1 346 YlkRGVPRERIAILSPTNYGLYKVEEQLSKFFIPhITIME 385
                 3446777778888888888888888888888775444333 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   1.0   1.2e-05     0.019      48     103 ..     208     261 ..     122     272 .. 0.82

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 1.2e-05
      AAA_14  48 dpekllelileklkeekktylflDEiqevpewekalkslvdegknldvivtGSnsk 103
                 +  k++ +i +++ + kk+yl++DE q +++++  + + + ++  +++i+ G  s+
  EFC39285.1 208 NLMKNYPEIADEICK-KKKYLIIDEYQDIDNFQAEIFEEFHKR-GCKIIAVGDDSQ 261
                 333344445555555.99***************9987777766.699999886655 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   1.0    0.0017       2.7       9     114 ..     116     248 ..     114     266 .. 0.64
   2 ?   -2.4   0.0       3.2   5.3e+03      41      94 ..     398     451 ..     383     455 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0017
      AAA_22   9 vvtGesGtGKTtll.rrlleqldeeakaee.........................erpevv.fvtlpsstsskdllrellralglelkaerlsseell. 79 
                 +v +++G+GKTt++  ++++  +  + +                           +++ ++ ++++ + +++k+ ++ + ++  +   +   +++ l+ 
  EFC39285.1 116 LVLACAGSGKTTTIiCKIVYMIKYLKIP-AhqimlttfsrlaandmkeklasigvKSKFTIgTIDAFAYKTLKKYWQYFDSQACVIEYG--YRLRNLMk 211
                 6788999999887422333333222222.134567778888888877777777776666667888888888888888888877776666..44444441 PP

      AAA_22  80 ..ealeqalraravielliiDEaqhlr..seealeeLrs 114
                     +++ + ++  ++ liiDE q ++  ++e++ee+++
  EFC39285.1 212 nyPEIADEICKK--KKYLIIDEYQDIDnfQAEIFEEFHK 248
                 014444555444..559********98777999998843 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 3.2
      AAA_22  41 evvfvtlpsstsskdllrellralglelka.erlsseellealeqalraraviel 94 
                 ++ +v+l+   +sk l  +++  +++++++ ++++  el++ l+ a+ ++++ el
  EFC39285.1 398 TTGKVCLSTIHKSKGLEWDIVFLVDSSNDKwKGDNDAELRRVLYVAVTRAKD-EL 451
                 3337777777788888899999999999999899999999999888888877.44 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.3      0.64     1e+03      65     139 ..      18     110 ..      14     117 .. 0.63
   2 ?    3.2   1.3     0.048        79      10      48 ..      98     137 ..      86     290 .. 0.72
   3 ?    6.5   0.0    0.0046       7.6      40     114 ..     339     410 ..     337     433 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.64
                 HHHHHHHHHGGGGTGG.....GEEEESSS-B--.........................-SEEEEEHHHHHHTH........HHHTTT-SEEEEE CS
      ResIII  65 slleqtleefkkflseayke.igkkvsgdkkka..................kekdstnkkilvttiqsldadseeeeeeseellrdrfdviiiD 139
                 + l+q  +e+k+++s+++ + ++++++  +++a                   ++ +++k+i++ +++++ +   + +  + +l++++++v++ D
  EFC39285.1  18 QTLKQQDDEVKELFSTHQPQeKEEIINAMSNEAislmpeinfggdeeiskpVKRVRKKKEIVFPSEEEIMKTF-TIDDVQIDLSEEQKQVVFGD 110
                 5566666777776666654444444444444444555555555555555776777888889998888888888.33666666666666676665 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.048
                 HHHHHHT......TTSEEEEEESTTSTHHHHH.HHHHHHH CS
      ResIII  10 eaienlleklkskrdkrglikmaTGtGKTlva.aklierl 48 
                 +  e+ ++ +  + +  +l+ +  G+GKT ++ +k+++ +
  EFC39285.1  98 DLSEEQKQVVFGDVNDDLLVLACAGSGKTTTIiCKIVYMI 137
                 555555554444556677777778******9955555443 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0046
                 HHHHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--.......-SEEEEEHHHH CS
      ResIII  40 vaaklierllkkgkeekflflvprkslleqtleefkkflseaykeigkkvsgdkkkakekdstnkkilvttiqsl 114
                 va k+ e+l++  ++e++ +l p++  l + +e+++kf+ ++ + i++k ++ k+++  +++t+ k++++ti++ 
  EFC39285.1 339 VAKKISEYLKRGVPRERIAILSPTNYGLYKVEEQLSKFFIPHIT-IMEKSKSLKEME--RHTTTGKVCLSTIHKS 410
                 6667778888888899************************9875.777777777776..8************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (874 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       723  (0.0403257); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.82u 0.39s 00:00:01.21 Elapsed: 00:00:00.59
# Mc/sec: 4495.45
//
Query:       EFC39286.1  [L=444]
Description: transcriptional intermediary factor 1 alpha [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    3.1e-07   30.3   2.8    3.1e-07   30.3   2.8    3.7  4  zf-RING_UBOX  RING-type zinc-finger
    1.9e-06   27.9   3.2    1.9e-06   27.9   3.2    4.6  4  zf-C3HC4_4    zinc finger of C3HC4-type, RING
      5e-06   26.3   3.5      5e-06   26.3   3.5    3.6  4  zf-C3HC4_2    Zinc finger, C3HC4 type (RING finger)
    5.2e-06   26.2   3.2    5.2e-06   26.2   3.2    4.0  4  zf-C3HC4      Zinc finger, C3HC4 type (RING finger)
    0.00015   21.8   6.3    0.00015   21.8   6.3    5.1  6  zf-B_box      B-box zinc finger
    0.00062   19.6   2.5    0.00062   19.6   2.5    3.9  4  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
     0.0045   17.3   3.0     0.0045   17.3   3.0    4.2  5  zf-RING_2     Ring finger domain
     0.0097   15.7   2.8     0.0097   15.7   2.8    4.1  4  Prok-RING_4   Prokaryotic RING finger family 4
  ------ inclusion threshold ------
      0.028   14.6   2.4      0.028   14.6   2.4    3.5  4  zf-RING_10    zinc RING finger of MSL2
      0.056   13.6   0.1        1.2    9.4   0.0    2.7  3  U-box         U-box domain


Domain annotation for each model (and alignments):
>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.3   2.8   1.7e-10   3.1e-07       1      26 [.      11      38 ..      11      54 .. 0.77
   2 ?   -6.5   3.3        10   1.8e+04       1       5 [.      83      87 ..      79      91 .. 0.65
   3 ?   -0.9   1.3      0.99   1.8e+03      20      25 ..     144     149 ..     137     164 .. 0.77
   4 ?    4.2   0.0     0.025        45      19      26 ..     362     371 ..     349     388 .. 0.75

  Alignments for each domain:
  == domain 1  score: 30.3 bits;  conditional E-value: 1.7e-10
  zf-RING_UBOX  1 CpIClelftdPlvlpCGHtFCreCl..w 26
                  C  C+el++dP vlpCGH+ C +C+   
    EFC39286.1 11 CKFCFELLQDPRVLPCGHSMCTRCImaN 38
                  999********336***********531 PP

  == domain 2  score: -6.5 bits;  conditional E-value: 10
  zf-RING_UBOX  1 CpICl 5 
                  Cp C+
    EFC39286.1 83 CPSCN 87
                  66665 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.99
  zf-RING_UBOX  20 FCreCl 25 
                   FC+eC 
    EFC39286.1 144 FCEECF 149
                   999997 PP

  == domain 4  score: 4.2 bits;  conditional E-value: 0.025
  zf-RING_UBOX  19 tFCreCl..w 26 
                   ++C+eC+  +
    EFC39286.1 362 NICKECIsaK 371
                   79*****541 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.9   3.2   1.1e-09   1.9e-06       1      27 [.      11      37 ..      11      44 .. 0.94
   2 ?   -0.8   1.7         1   1.8e+03      30      42 .]      74      86 ..      68      90 .. 0.72
   3 ?   -3.0   7.0         5   8.9e+03      15      28 ..     139     152 ..     123     156 .. 0.73
   4 ?    1.7   0.0      0.17     3e+02      18      27 ..     361     370 ..     353     381 .. 0.80

  Alignments for each domain:
  == domain 1  score: 27.9 bits;  conditional E-value: 1.1e-09
  zf-C3HC4_4  1 CPiCldYLekPvsleCGhsfClsCiss 27
                C  C ++L++P  l+CGhs+C +Ci +
  EFC39286.1 11 CKFCFELLQDPRVLPCGHSMCTRCIMA 37
                99***********************75 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1
  zf-C3HC4_4 30 kepdgeqllCplC 42
                ++++g  + Cp C
  EFC39286.1 74 NKKEGICFNCPSC 86
                4455556999998 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 5
  zf-C3HC4_4  15 eCGhsfClsCissl 28 
                 +C   fC +C +s+
  EFC39286.1 139 DCNSRFCEECFTSI 152
                 36678999998775 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.17
  zf-C3HC4_4  18 hsfClsCiss 27 
                 +++C +Cis+
  EFC39286.1 361 FNICKECISA 370
                 789*****96 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.3   3.5   2.8e-09     5e-06       2      30 ..      11      38 ..      10      44 .. 0.91
   2 ?   -5.4   3.0        10   1.8e+04      36      40 .]      82      86 ..      79      86 .. 0.79
   3 ?    2.4   6.2     0.082   1.5e+02       2      28 ..     125     150 ..     124     156 .. 0.79
   4 ?   -1.8   0.2       1.6   2.8e+03      22      28 ..     363     369 ..     361     372 .. 0.78

  Alignments for each domain:
  == domain 1  score: 26.3 bits;  conditional E-value: 2.8e-09
  zf-C3HC4_2  2 CpiCldmlkdpsvvtpCgHvfCqkCilrs 30
                C+ C++ l+dp +v pCgH+ C  Ci+  
  EFC39286.1 11 CKFCFELLQDP-RVLPCGHSMCTRCIMAN 38
                ***********.**************975 PP

  == domain 2  score: -5.4 bits;  conditional E-value: 10
  zf-C3HC4_2 36 eCPlC 40
                +CP C
  EFC39286.1 82 NCPSC 86
                58888 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.082
  zf-C3HC4_2   2 CpiCldmlkdpsvvtpCgHvfCqkCil 28 
                 C+ C   + + +    C+ +fC++C+ 
  EFC39286.1 125 CANCETNIVQ-VECEDCNSRFCEECFT 150
                 6667777766.57889*********97 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 1.6
  zf-C3HC4_2  22 fCqkCil 28 
                  C++Ci 
  EFC39286.1 363 ICKECIS 369
                 5999985 PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   3.2   2.9e-09   5.2e-06       1      31 [.      11      40 ..      11      47 .. 0.91
   2 ?   -2.4   2.0       2.5   4.5e+03      37      41 .]      82      86 ..      72      94 .. 0.71
   3 ?    3.6   8.1     0.034        61       1      29 [.     125     152 ..     125     163 .. 0.92
   4 ?   -1.1   0.4         1   1.8e+03      21      27 ..     363     369 ..     361     371 .. 0.80

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 2.9e-09
                -TTT-S--SS-E.E-TTS--B-CHHHHHHHH CS
    zf-C3HC4  1 CpiCleeakepnelleCkHsfCskCirkilk 31
                C+ C+e +++p  +l+C+Hs+C+ Ci   ++
  EFC39286.1 11 CKFCFELLQDPR-VLPCGHSMCTRCIMANIN 40
                9***********.*************98887 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.5
                --TTT CS
    zf-C3HC4 37 kCPlC 41
                +CP C
  EFC39286.1 82 NCPSC 86
                35555 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.034
                 -TTT-S--SS-E.E-TTS--B-CHHHHHH CS
    zf-C3HC4   1 CpiCleeakepnelleCkHsfCskCirki 29 
                 C+ C +++++     +C+ +fC++C ++i
  EFC39286.1 125 CANCETNIVQVE-CEDCNSRFCEECFTSI 152
                 999*******98.************9987 PP

  == domain 4  score: -1.1 bits;  conditional E-value: 1
                 B-CHHHH CS
    zf-C3HC4  21 fCskCir 27 
                 +C++Ci+
  EFC39286.1 363 ICKECIS 369
                 7999996 PP

>> zf-B_box  B-box zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.2       2.3   4.1e+03      22      29 ..       7      14 ..       5      19 .. 0.68
   2 ?    1.3   0.3      0.21   3.9e+02      21      30 ..      26      35 ..      24      39 .. 0.82
   3 ?   -2.6   2.5       3.6   6.4e+03       8      28 ..      82      85 ..      75      96 .. 0.53
   4 !   21.8   6.3   8.4e-08   0.00015       3      41 ..     122     165 ..     120     166 .. 0.89
   5 ?    2.0   0.9      0.13   2.3e+02      29      42 .]     175     186 ..     173     186 .. 0.81
   6 ?   -1.1   0.1       1.2   2.2e+03      25      29 ..     363     367 ..     361     371 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.3
    zf-B_box 22 qqplCeeC 29
                +++ C+ C
  EFC39286.1  7 ESLSCKFC 14
                56778888 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.21
    zf-B_box 21 CqqplCeeCs 30
                C++ +C  C 
  EFC39286.1 26 CGHSMCTRCI 35
                99*******4 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 3.6
    zf-B_box  8 eHknkpatlfCedCqqplCee 28
                +++                 +
  EFC39286.1 82 NCP-----------------S 85
                333.................2 PP

  == domain 4  score: 21.8 bits;  conditional E-value: 8.4e-08
    zf-B_box   3 etkCpeHknkpatlfCedCqqplCeeCstgeHr.....gHevvp 41 
                   +C +++++  +  CedC++ +CeeC t++H       H+  p
  EFC39286.1 122 GETCANCETNIVQVECEDCNSRFCEECFTSIHApkffaSHKKAP 165
                 579*****************************988887788765 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.13
    zf-B_box  29 CstgeHrgHevvpl 42 
                 C  + H++H++vp+
  EFC39286.1 175 C--KRHNNHTCVPI 186
                 4..78999999987 PP

  == domain 6  score: -1.1 bits;  conditional E-value: 1.2
    zf-B_box  25 lCeeC 29 
                 +C+eC
  EFC39286.1 363 ICKEC 367
                 78888 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   2.5   3.5e-07   0.00062       3      31 ..       9      36 ..       7      43 .. 0.90
   2 ?   -1.3   2.6       1.1     2e+03      39      47 ..      82      90 ..      75      93 .. 0.77
   3 !    9.8   5.1   0.00038      0.68       3      35 ..     123     154 ..     121     164 .. 0.89
   4 ?   -1.5   0.1       1.3   2.4e+03      25      30 ..     363     368 ..     359     371 .. 0.76

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 3.5e-07
                SB-TTTSSSBS-EEETTEEEEEE-HHHHH CS
  zf-C3HC4_3  3 eeCviClerprnvvllpCgHlvlCeeCae 31
                  C+ C+e  ++  +lpCgH  +C +C  
  EFC39286.1  9 LSCKFCFELLQDPRVLPCGHS-MCTRCIM 36
                68*******************.*****75 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.1
                B-TTT--B- CS
  zf-C3HC4_3 39 kCpiCrrpi 47
                +Cp C+++ 
  EFC39286.1 82 NCPSCNKEC 90
                688888875 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00038
                 SB-TTTSSSBS-EEETTEEEEEE-HHHHHHHHH CS
  zf-C3HC4_3   3 eeCviClerprnvvllpCgHlvlCeeCaekllk 35 
                 e+C  C ++  +v + +C+   +CeeC++++++
  EFC39286.1 123 ETCANCETNIVQVECEDCNSR-FCEECFTSIHA 154
                 68*******************.*******9975 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 1.3
                 E-HHHH CS
  zf-C3HC4_3  25 lCeeCa 30 
                 +C+eC 
  EFC39286.1 363 ICKECI 368
                 799996 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   3.0   2.5e-06    0.0045       2      32 ..      10      37 ..       9      43 .. 0.79
   2 ?   -1.1   1.3       1.4   2.5e+03      39      43 ..      79      86 ..      69      92 .. 0.68
   3 !    6.1   6.6    0.0078        14       2      33 ..     124     152 ..     123     163 .. 0.75
   4 ?   -3.0   0.2       5.4   9.7e+03      20      29 ..     174     183 ..     167     191 .. 0.63
   5 ?   -1.4   0.0       1.8   3.2e+03      25      31 ..     363     369 ..     360     374 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 2.5e-06
   zf-RING_2  2 eCpICleelssadsvlllpCgHvfhreCler 32
                +C  C+e l   +++++lpCgH+++  C++ 
  EFC39286.1 10 SCKFCFELL---QDPRVLPCGHSMCTRCIMA 37
                7****9666...4556668**********86 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.4
   zf-RING_2 39 t...CPlC 43
                    CP C
  EFC39286.1 79 IcfnCPSC 86
                14558888 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0078
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreClerw 33 
                 +C+ C  ++    +v +++C+  f++eC++ +
  EFC39286.1 124 TCANCETNIV---QVECEDCNSRFCEECFTSI 152
                 6888865663...455668*999*****9864 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 5.4
   zf-RING_2  20 pCgHvfhreC 29 
                 +C+ +  ++C
  EFC39286.1 174 KCKRHNNHTC 183
                 6876555556 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 1.8
   zf-RING_2  25 fhreCle 31 
                 +++eC++
  EFC39286.1 363 ICKECIS 369
                 7999986 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   2.8   5.4e-06    0.0097       1      26 [.      11      36 ..      11      43 .. 0.92
   2 ?    0.3   1.8      0.35   6.3e+02      32      40 ..      82      90 ..      70      95 .. 0.73
   3 ?    0.2   7.1      0.39     7e+02       1      28 [.     125     152 ..     125     156 .. 0.91
   4 ?   -0.2   0.1      0.52   9.4e+02      20      28 ..     363     371 ..     361     374 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 5.4e-06
  Prok-RING_4  1 CvlCgeqekkailepCgHlvCkeCfd 26
                 C++C e  +++++ pCgH +C +C  
   EFC39286.1 11 CKFCFELLQDPRVLPCGHSMCTRCIM 36
                 9***********************75 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.35
  Prok-RING_4 32 sCPlCqrri 40
                  CP C+++ 
   EFC39286.1 82 NCPSCNKEC 90
                 6*****994 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.39
  Prok-RING_4   1 CvlCgeqekkailepCgHlvCkeCfdsk 28 
                  C  C+++  ++  e C+  +C+eCf s 
   EFC39286.1 125 CANCETNIVQVECEDCNSRFCEECFTSI 152
                  8999999999999************875 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.52
  Prok-RING_4  20 vCkeCfdsk 28 
                  +CkeC ++k
   EFC39286.1 363 ICKECISAK 371
                  8****8765 PP

>> zf-RING_10  zinc RING finger of MSL2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   2.4   1.5e-05     0.028       1      33 [.       9      38 ..       9      46 .. 0.85
   2 ?   -3.0   1.0       4.6   8.2e+03      36      45 ..      79      89 ..      72      99 .. 0.57
   3 ?   -3.2   3.3       5.3   9.5e+03      14      29 ..     133     148 ..     121     154 .. 0.55
   4 ?   -1.0   0.0       1.1     2e+03      23      32 ..     361     370 ..     357     373 .. 0.78

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.5e-05
  zf-RING_10  1 lsCvvCckLLvdPlepkekeCqHyvCrlCvgkk 33
                lsC  C +LL+dP       C+H++C +C+  +
  EFC39286.1  9 LSCKFCFELLQDPRV---LPCGHSMCTRCIMAN 38
                89**********965...58*********9765 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.6
  zf-RING_10 36 lkpsCsqCk.d 45
                +  +C++C+ +
  EFC39286.1 79 ICFNCPSCNkE 89
                55566666632 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 5.3
  zf-RING_10  14 lepkekeCqHyvCrlC 29 
                 ++ + ++C+   C  C
  EFC39286.1 133 VQVECEDCNSRFCEEC 148
                 3334455666666655 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.1
  zf-RING_10  23 HyvCrlCvgk 32 
                  ++C+ C+  
  EFC39286.1 361 FNICKECISA 370
                 679***9876 PP

>> U-box  U-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0   0.00065       1.2       4      34 ..       8      39 ..       6      64 .. 0.71
   2 ?    0.9   0.0       0.3   5.4e+02      56      72 ..     104     120 ..      87     121 .. 0.84
   3 ?   -3.9   0.0       9.2   1.7e+04      52      70 ..     228     246 ..     223     247 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00065
                GGB-TTT-SB-SSEEEETTTEEE.EHHHHHHH CS
       U-box  4 efldpitlelmkdPvilpsgvvv.drstiekh 34
                 + ++  +el++dP +lp g+++  r ++++ 
  EFC39286.1  8 SLSCKFCFELLQDPRVLPCGHSMcTRCIMANI 39
                578999**************655155555544 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.3
                 E-HHHHHHHHHHHHHCT CS
       U-box  56 pnlelKekIdefleekr 72 
                  n+ lK  ++++++e++
  EFC39286.1 104 INYDLKSTVENYMMERE 120
                 5899**********987 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 9.2
                 GGSEE-HHHHHHHHHHHHH CS
       U-box  52 dqlipnlelKekIdeflee 70 
                 +q + ++ +  +Id++l++
  EFC39286.1 228 NQETYEMRVNTMIDNYLAQ 246
                 5555666677889998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (444 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1435  (0.0800379); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 2485.30
//
Query:       EFC39287.1  [L=277]
Description: hypothetical protein NAEGRDRAFT_81360 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (277 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       453  (0.0252663); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1577.44
//
Query:       EFC39288.1  [L=428]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.7e-82  276.2   9.0    5.5e-82  276.0   9.0    1.0  1  Serpin          Serpin (serine protease inhibitor)
  ------ inclusion threshold ------
      0.063   13.2   1.2       0.12   12.3   0.5    1.8  2  Peptidase_C3    3C cysteine protease (picornain 3C)
       0.26   11.6   4.1          1    9.7   0.8    2.8  2  T3RM_EcoP15I_C  Type III R-M EcoP15I C-terminal domain


Domain annotation for each model (and alignments):
>> Serpin  Serpin (serine protease inhibitor)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  276.0   9.0   9.2e-86   5.5e-82       2     370 ..      30     424 ..      29     425 .. 0.84

  Alignments for each domain:
  == domain 1  score: 276.0 bits;  conditional E-value: 9.2e-86
                 HHHHHHHHHHHHHHHHSTTSSEEE-HHHHHHHHHHHHHTB-HHHHHHHHHHHTGCC....HCHHHHHHHHHHH.HHHHCS.......SGGTSEEEEEEE CS
      Serpin   2 antkfaldlfkalskekpskNiifSPlsistaLallllGakgetaeellevLglne....sdeeelhealekl.lsrlne.......seekdkelkian 88 
                 a+++f+  lf ++ +e+ ++N+i+SP+si++a+  + lG++get +e+ + L l+e     + e+  e+++k+  s+l++         ++++ l+ian
  EFC39288.1  30 AQNEFSSALFGQFVQENGNGNLIISPFSIYIAMMNCMLGTGGETLREMIDGLFLREsfnsCKMENAVEQFQKWkESELKQysgmiknIVQNESVLSIAN 128
                 689*************************************************88888887444444556666666666667777776345899****** PP

                 EEEEETTSEB-HHHHHHHHHHHS-EEEEE-TTTHHH.HHHHHHHHHHHHTTTSSSSSSSTTSS-TTECEEEEEEEEEEEEBSS--BGGGEEEEEEESSS CS
      Serpin  89 glfvekglklkeeflklakklykaevesvdfkddee.arkkINswvekqTngkIkdllsegsidsdtrlvlvNaiyFkGkWeepFqpeatreekFyvne 186
                 ++++ek+l +k+ef +++ + ++++ + ++fk+ ++  +k+IN+wv+++T+++Ik+l+s+  +dsdt +v+vNaiyF+GkW+++F++++t e++F + +
  EFC39288.1 129 RIYLEKSLGVKNEFINELVDQFDSQTQLANFKGMANiEVKNINAWVASNTKNNIKNLISK--LDSDTLMVIVNAIYFNGKWKHQFNKNRTIEKSFNTLN 225
                 ************************************************************..***********************************99 PP

                 SEEEEEEEEEEE...EEEEEEEETTTTEEEEEEEBGG.SEEEEEEEE........SSTTT.HHHHHHHHSHHHHHHHHHHGEEEEEEE.EEEEE-EEEE CS
      Serpin 187 gekvkvpmMsqe...gkfkyaedeelnakvlelpYkg.nlsmlillP........deekg.leelekkltaerleewlsklkmkkeke.evslPkfkie 271
                 ge  + +mMs e   +kf y+e +  ++++l+lpY++ ++ m+++ P        ++e++  + l++k     l ++ +   ++++k  ++++Pkfk+e
  EFC39288.1 226 GEC-NCQMMSLEdckSKFLYEEMD--DYQILQLPYTDeEYCMTFIKPnddleideENETEfNKWLQSK-----LTDISRLNPSESVKMnRIQIPKFKFE 316
                 987.9****877333455556655..*********7779********765555322222222233344.....44444444444444456********* PP

                 EEE.EHHHHHHH..TTHCGGGSTTTB.BTTTBSS...SSEEEEEEEEEEEEEESSSEEEEEEEEE...ECCTTCS-SSCEEEEECSEEEEEEEETTTTE CS
      Serpin 272 esi.dlkevLqk..lGlkdlFseneadlsgiskk...eplfvsevlhkafievnEeGteaaaata...vatllskksspvefkvdrPFlflireektgl 361
                 +++ ++  +  k  +++++lFs+++ad+s+++++   + ++vs+++hka i+v+E Gt a+aata     +   ++++  ef++drPF f++++ +t++
  EFC39288.1 317 KQFdNIIPTIAKkpFEINRLFSPTNADFSNMLSNpqvDGVCVSQIIHKACIQVDESGTVASAATAvacKRKRRAASEEVYEFIADRPFAFILHHVPTQS 415
                 *996677777554489****************666789**************************9653244556678889******************* PP

                 EEEEEEESS CS
      Serpin 362 iLFlGkvvn 370
                 +LF+Gk+++
  EFC39288.1 416 VLFVGKINE 424
                 ******975 PP

>> Peptidase_C3  3C cysteine protease (picornain 3C)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.5   1.9e-05      0.12      59     164 ..     140     241 ..     117     243 .. 0.86
   2 ?   -2.6   0.0      0.76   4.6e+03      65      85 ..     368     389 ..     353     394 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.9e-05
                   EE.EEEEE-TT--EEEEEEEEESSS--B---GGGS-SS---EEEEEEEE-SSSSTTEEEEEEEEEEEEEE.EETTEEEEEEEEESS---TT-TT-EE CS
  Peptidase_C3  59 sdlevelvdqegmpldlaivklkrgekfkdirkylaarikkgkpvvllinnneagrlivsveavtakgkiktldgtttartlsYkaktkaGmCGgvv 155
                   +++  elvdq++ +  la  k   +  +k+i  ++a++   +++   li + + + l+v v+a+  +gk      ++  rt+   ++t  G C   +
    EFC39288.1 140 NEFINELVDQFDSQTQLANFKGMANIEVKNINAWVASN--TKNNIKNLISKLDSDTLMVIVNAIYFNGKW--KHQFNKNRTIEKSFNTLNGECNCQM 232
                   3466788*****************************54..578888999*******************99..7899*****************9998 PP

                   EE....TTE CS
  Peptidase_C3 156 iakeegngk 164
                   ++ e+ + k
    EFC39288.1 233 MSLEDCKSK 241
                   887776665 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.76
                   EE-TT-.-EEEEEEEEESSS-- CS
  Peptidase_C3  65 lvdqeg.mpldlaivklkrgek 85 
                   +vd+ g + + +++v +kr  +
    EFC39288.1 368 QVDESGtVASAATAVACKRKRR 389
                   4555551456678888888765 PP

>> T3RM_EcoP15I_C  Type III R-M EcoP15I C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1     0.058   3.5e+02      35      64 ..     126     156 ..     100     161 .. 0.82
   2 ?    9.7   0.8   0.00017         1      47      93 ..     178     226 ..     173     230 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.058
  T3RM_EcoP15I_C  35 iekkLYliek.glesealkaLiekldedkef 64 
                     i +++Yl ++ g+++e +++L++++d+++++
      EFC39288.1 126 IANRIYLEKSlGVKNEFINELVDQFDSQTQL 156
                     6678888765589999999999999988877 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00017
  T3RM_EcoP15I_C  47 esealkaLiekldedkefniekivlfgysfe..skelreleenlkqlkn 93 
                     +++++k+Li+kld+d+ + i + ++f+ + +  +++ r++e+  ++l+ 
      EFC39288.1 178 TKNNIKNLISKLDSDTLMVIVNAIYFNGKWKhqFNKNRTIEKSFNTLNG 226
                     6899**********************98776559999999999998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (428 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1458  (0.0813208); expected 358.6 (0.02)
Passed bias filter:                      569  (0.0317363); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 2460.78
//
Query:       EFC39289.1  [L=182]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0016   18.1   2.7     0.0035   17.1   2.7    1.6  1  AT_hook       AT hook motif
  ------ inclusion threshold ------
      0.045   13.5   2.3      0.065   13.0   2.3    1.2  1  RFX5_DNA_bdg  RFX5 DNA-binding domain
       0.07   12.9   4.1      0.088   12.5   4.1    1.2  1  Hydrolase_3   haloacid dehalogenase-like hydrolase


Domain annotation for each model (and alignments):
>> AT_hook  AT hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   2.7   5.8e-07    0.0035       1      11 [.     147     157 ..     147     159 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 5.8e-07
     AT_hook   1 kRkRGRPrKaa 11 
                 kR+RGRPrK++
  EFC39289.1 147 KRPRGRPRKNS 157
                 8********97 PP

>> RFX5_DNA_bdg  RFX5 DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   2.3   1.1e-05     0.065      56     101 ..     135     177 ..     130     182 .] 0.70

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.1e-05
  RFX5_DNA_bdg  56 akqdtedtasdakRkRGRPRkksggsgernstpeksaaavdsaqss 101
                   +k++ e   +  kR RGRPRk s  s +++s+++       s+ s 
    EFC39289.1 135 IKEEEELKKTLPKRPRGRPRKNSFESMNNSSSSNCV---SSSSSSK 177
                   566666666778***********9998877776643...3344444 PP

>> Hydrolase_3  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   4.1   1.5e-05     0.088      76     200 ..       4     133 ..       1     141 [. 0.77

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.5e-05
                  E--B-HHHHHHHHHHHHHTT....CEEEEEESSEEEESTT.THHHHHHHHHCHCTCEEEESHHHHHCHCSESEEEEES-HHHHHHHHHHHHHHCTTTE CS
  Hydrolase_3  76 kstiskedvkeiikllkenn....veillytedkvyvlnkeksekkkkeeektkkkkeeidseeeledeeiakililkdkekldelekelksklnkll 169
                  ++ti+++++  ++ ll +n        +l+++d+ y+  +  + ++++  ++t+ +++++ ++ e+ + ++ k++  k+++++++ +  +k ++ + +
   EFC39289.1   4 TNTIHEQTLLFLLHLLLQNSnddsFLPCLENDDNNYCPVN--NTSTNNTTNNTYANNNIVFEKVEECKLQPSKLIEMKSSNHTSNKKHSMKTLNYNST 99 
                  5777888888888887777767778889999*******99..66777777777777778888888888899999966666666666555555555444 PP

                  ...EEEEESTTEEEEEETT-SHHHHHHHHHHHCT CS
  Hydrolase_3 170 ...titssskgyleimpkgvsKgtalkklakeln 200
                     +i ss + +++ +p ++sK + + +++++l 
   EFC39289.1 100 ttpKINSSYPPHVNTTPSNISKPNNVFFIVSTLE 133
                  567********************99999887775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1195  (0.0666518); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.31s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 1024.34
//
Query:       EFC39290.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.2e-35  120.1   2.3    1.9e-15   56.3   0.0    3.7  4  DUF4116    Domain of unknown function (DUF4116)
     0.0047   16.6   0.1      0.021   14.6   0.0    2.2  2  ubiquitin  Ubiquitin family


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.0   3.3e-12   2.9e-08       1      38 [.      78     116 ..      78     128 .. 0.85
   2 !   12.1   0.1   1.4e-05      0.12      18      45 ..     122     149 ..     117     153 .. 0.87
   3 !   28.3   0.3   1.2e-10   1.1e-06       1      46 [.     130     175 ..     130     179 .. 0.95
   4 !   56.3   0.0   2.1e-19   1.9e-15       1      48 [.     181     228 ..     181     229 .. 0.97

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 3.3e-12
     DUF4116   1 DrEivleavkkngs.alkylseeLknDkeivlkAvkqng 38 
                 Dr+++l +v+k+gs alk + e L+nD+ei+lkAv ++ 
  EFC39290.1  78 DRDVALAVVSKHGSdALKIIHETLRNDREIILKAVSKDD 116
                 9***********988********************9986 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 1.4e-05
     DUF4116  18 ylseeLknDkeivlkAvkqngtalsyas 45 
                 y+ + L++D+ +v++ v+ n + l+ ++
  EFC39290.1 122 YIGKTLRRDRKFVKELVQENWILLKDMD 149
                 89999***************99998776 PP

  == domain 3  score: 28.3 bits;  conditional E-value: 1.2e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 Dr +v+e+v+ n+  lk  + +++ D ei+ +A+k+n+ a++y+++
  EFC39290.1 130 DRKFVKELVQENWILLKDMDLDIREDEEICRAALKRNPRAIRYVHN 175
                 9*******************************************95 PP

  == domain 4  score: 56.3 bits;  conditional E-value: 2.1e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 +rE++le+vk++g++l+y+ ++LknD+ei l A++qn++a++++  +L
  EFC39290.1 181 NREFMLEIVKQYGLSLEYIGKSLKNDREINLTALNQNPNAFRFVGQDL 228
                 8*******************************************9887 PP

>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.39   3.5e+03      41      53 ..     196     208 ..     193     210 .. 0.82
   2 !   14.6   0.0   2.4e-06     0.021       2      72 .]     247     319 ..     246     319 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.39
                 EEETTEEE-TTSB CS
   ubiquitin  41 LiysGkvLedert 53 
                 L y Gk L+++r 
  EFC39290.1 196 LEYIGKSLKNDRE 208
                 7899****99986 PP

  == domain 2  score: 14.6 bits;  conditional E-value: 2.4e-06
                 EEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE...-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   2 tvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvL...edertleeygiqdgstlhlvlrlr 72 
                 ++k++ g+++ + v+++d+ + +  ++ e  g   +  r++++ k++   +de+tl+e+ i ++s+l + +rlr
  EFC39290.1 247 HIKSMAGRDLKVYVNPEDSFRMIRLQVVEAWGN-LDGVRIVHKSKPIpeeDDEKTLKELEINSDSKLTMIFRLR 319
                 799999999999999999999999999988875.6899**********9999*****************99976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       851  (0.047465); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 1804.65
//
Query:       EFC39291.1  [L=292]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    8.1e-22   75.4   9.6     0.0023   17.8   0.0    7.1  7  LRR_6        Leucine Rich repeat
    2.4e-17   62.5   4.5    6.9e-06   25.7   0.3    3.6  3  LRR_8        Leucine rich repeat
    7.3e-11   42.1  20.3     0.0017   18.7   0.6    5.6  7  LRR_4        Leucine Rich repeats (2 copies)
    1.4e-06   28.1   0.6         55    4.9   0.0    7.2  7  LRR_1        Leucine Rich Repeat
  ------ inclusion threshold ------
      0.012   15.5   0.1      0.025   14.5   0.1    1.4  1  F-box-like   F-box-like
      0.044   13.3   0.1      0.095   12.2   0.1    1.6  1  PI-TkoII_IV  DNA polymerase II intein Domain IV
      0.048   13.5   0.0        5.6    6.8   0.0    2.7  2  DUF4347      Domain of unknown function (DUF4347)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.0   2.5e-05     0.064       3      23 ..     113     133 ..     111     134 .. 0.90
   2 !   16.1   0.0   3.3e-06    0.0085       4      24 .]     138     158 ..     135     158 .. 0.90
   3 !   17.8   0.0     9e-07    0.0023       4      24 .]     162     182 ..     159     182 .. 0.94
   4 !    6.5   0.0    0.0038       9.8       4      24 .]     186     206 ..     183     206 .. 0.90
   5 !   11.9   0.1   7.3e-05      0.19       4      24 .]     210     230 ..     207     230 .. 0.93
   6 !    9.5   0.1   0.00042       1.1       3      24 .]     233     254 ..     231     254 .. 0.90
   7 ?   -1.1   0.0       1.1   2.7e+03       4      10 ..     258     264 ..     256     266 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.5e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 + Lt+Ld+  N++g +Ga+ +
  EFC39291.1 113 SQLTKLDIGMNKLGVKGAKEI 133
                 67****************987 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 3.3e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  L+eL++ +N+Ig+eGae ++
  EFC39291.1 138 QLRELNIIYNNIGNEGAEYIS 158
                 59***************9885 PP

  == domain 3  score: 17.8 bits;  conditional E-value: 9e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+Ld+++N ++ eG+++++
  EFC39291.1 162 NLTYLDIACNRMDVEGVKSIC 182
                 8******************98 PP

  == domain 4  score: 6.5 bits;  conditional E-value: 0.0038
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt L++  N I  eGa+ L+
  EFC39291.1 186 QLTDLSIHRNSIEKEGAKYLS 206
                 599**************9885 PP

  == domain 5  score: 11.9 bits;  conditional E-value: 7.3e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt+Ld+++ dI+  Ga+ ++
  EFC39291.1 210 QLTKLDIACSDITHNGAKHIC 230
                 69****************998 PP

  == domain 6  score: 9.5 bits;  conditional E-value: 0.00042
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L++ +N +  + a+ ++
  EFC39291.1 233 NNLTALNIFDNRLKADSAKLIS 254
                 79*************9999875 PP

  == domain 7  score: -1.1 bits;  conditional E-value: 1.1
       LRR_6   4 hLteLdL 10 
                 +L++Ld+
  EFC39291.1 258 NLKYLDI 264
                 89***97 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   0.1   4.3e-07    0.0011      20      61 .]     108     149 ..     106     149 .. 0.94
   2 !   25.7   0.3   2.7e-09   6.9e-06       3      61 .]     139     197 ..     139     197 .. 0.98
   3 !   25.5   0.3   3.1e-09   7.9e-06       2      60 ..     210     268 ..     209     269 .. 0.96

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 4.3e-07
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 a +++s+L+ Ld++ N+l +  ++ +  L++Lr+L++ +N++
  EFC39291.1 108 ALQKMSQLTKLDIGMNKLGVKGAKEIGKLKQLRELNIIYNNI 149
                 6789*********************************99997 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 2.7e-09
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L++L++  N++ + + e  ++l+nL++Ld+ +N++++   +++  L++L+ L + +N +
  EFC39291.1 139 LRELNIIYNNIGNEGAEYISQLENLTYLDIACNRMDVEGVKSICKLKQLTDLSIHRNSI 197
                 89*******************************************************86 PP

  == domain 3  score: 25.5 bits;  conditional E-value: 3.1e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+Ld+ ++ +t+ + +    ++nL+ L++ +N+l+  s++ +s +++L++Ld+ ++ 
  EFC39291.1 210 QLTKLDIACSDITHNGAKHICEMNNLTALNIFDNRLKADSAKLISEMKNLKYLDIHRDE 268
                 79****************************************************99876 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       2.5   6.4e+03      30      39 ..      18      27 ..      12      31 .. 0.63
   2 ?   -3.5   0.0       6.5   1.7e+04      26      33 ..      59      65 ..      54      73 .. 0.53
   3 !    9.0   0.0   0.00075       1.9      15      36 ..     105     125 ..     101     129 .. 0.86
   4 !   14.6   0.7   1.3e-05     0.033       2      34 ..     114     148 ..     113     161 .. 0.80
   5 !   16.0   0.2   4.8e-06     0.012       1      39 [.     137     175 ..     137     180 .. 0.80
   6 !   16.0   0.5   4.8e-06     0.012       2      39 ..     162     197 ..     161     225 .. 0.76
   7 !   18.7   0.6   6.6e-07    0.0017       2      32 ..     234     266 ..     233     271 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.5
                -.-S-----G CS
       LRR_4 30 LsgNnlitdl 39
                L+++n+++d+
  EFC39291.1 18 LNNFNFPDDI 27
                4566677776 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 6.5
                -EEE-.-S CS
       LRR_4 26 keLdLsgN 33
                ++++L ++
  EFC39291.1 59 TKINL-HF 65
                56666.33 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00075
                 E-S-HHH-TT--EEE-.-S--- CS
       LRR_4  15 diplleklpnLkeLdLsgNnli 36 
                  ++ l+k+ +L++Ld+ g+n++
  EFC39291.1 105 VLDALQKMSQLTKLDI-GMNKL 125
                 4778999*********.88887 PP

  == domain 4  score: 14.6 bits;  conditional E-value: 1.3e-05
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNn 34 
                 +L++Ld++ N+l    +   ++kl++L+eL++  Nn
  EFC39291.1 114 QLTKLDIGMNKLGV-KGakeIGKLKQLRELNIIYNN 148
                 79******989884.34355779********97773 PP

  == domain 5  score: 16.0 bits;  conditional E-value: 4.8e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 ++L++L++  N++   +   +++l nL++Ld+  +n+  d+
  EFC39291.1 137 KQLRELNIIYNNIGNEGAeyISQLENLTYLDI-ACNRM-DV 175
                 58************877766557********9.66665.55 PP

  == domain 6  score: 16.0 bits;  conditional E-value: 4.8e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 nL++Ld++ N++   +   + kl++L+ L++++N    ++
  EFC39291.1 162 NLTYLDIACNRMDVEGVksICKLKQLTDLSIHRN----SI 197
                 9*******99*88555554448*********999....33 PP

  == domain 7  score: 18.7 bits;  conditional E-value: 6.6e-07
                 S--EEE--SS---.E-S-..HHH.-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqlt.dipl..lek.lpnLkeLdLsg 32 
                 nL+ L++++N+l+ d  +  l + ++nLk+Ld+++
  EFC39291.1 234 NLTALNIFDNRLKaD--SakLISeMKNLKYLDIHR 266
                 9************55..4456666*********65 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.099   2.5e+02       1      22 [.     114     135 ..     114     136 .. 0.81
   2 ?    4.0   0.0     0.041   1.1e+02       1      20 [.     138     157 ..     138     160 .. 0.74
   3 ?    4.9   0.0     0.022        55       1      23 []     162     184 ..     162     184 .. 0.88
   4 ?   -0.2   0.0         1   2.7e+03       2      21 ..     187     206 ..     186     208 .. 0.75
   5 ?    0.8   0.0      0.47   1.2e+03       2      21 ..     211     230 ..     210     232 .. 0.77
   6 ?    1.4   0.0       0.3   7.6e+02       1      12 [.     234     245 ..     234     255 .. 0.83
   7 ?    2.9   0.0       0.1   2.5e+02       1      12 [.     258     269 ..     258     290 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.099
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L++Ld++ n l+ +++  + +
  EFC39291.1 114 QLTKLDIGMNKLGVKGAKEIGK 135
                 599********98888777665 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.041
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +Lr+L++ +n++++ +++++
  EFC39291.1 138 QLRELNIIYNNIGNEGAEYI 157
                 59****98888877766665 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.022
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL++Ld+  n+ +  +  s+++L
  EFC39291.1 162 NLTYLDIACNRMDVEGVKSICKL 184
                 8*********9988888888876 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 1
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L + +n+++  ++ +++
  EFC39291.1 187 LTDLSIHRNSIEKEGAKYLS 206
                 78899999999877776665 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.47
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L++Ld+    +++ ++ +++
  EFC39291.1 211 LTKLDIACSDITHNGAKHIC 230
                 999**988888877777765 PP

  == domain 6  score: 1.4 bits;  conditional E-value: 0.3
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+ L++ +n+l
  EFC39291.1 234 NLTALNIFDNRL 245
                 89*****99998 PP

  == domain 7  score: 2.9 bits;  conditional E-value: 0.1
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++Ld+ +  +
  EFC39291.1 258 NLKYLDIHRDEI 269
                 8******77665 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.1   9.7e-06     0.025       5      35 ..      24      55 ..      22      59 .. 0.92

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 9.7e-06
  F-box-like  5 PdEiLlqIFsyLpps.dLlrlalVCrrWrrva 35
                Pd+i+++I  yLp +  L+++ l +++W++++
  EFC39291.1 24 PDDICSEIILYLPHEfLLWSGVLISKQWKQII 55
                ************9998899***********99 PP

>> PI-TkoII_IV  DNA polymerase II intein Domain IV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.1   3.7e-05     0.095      13     121 ..     104     212 ..      92     224 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 3.7e-05
                  EHHHHHHTS-GGGCTTEEE.EEESTT-TTHHH.HHHHHHHHHTTSS---TTHHHHHHHHHHCTSEEE-SSSEEES-HHHHHHHHHHHHHHHHH-EEET CS
  PI-TkoII_IV  13 nlvelllklpeeetadivl.tipvkGrknffk.GmlrtlrwifgeekrirtarrylkhleklGyvklkkrGyevldweglkkykklyeklvekvkynG 108
                  n+ + l k+ +    di +  + vkG k++ k   lr l  i+++         y+  le+l y+ +    ++v   +++ k k+l +  +++   + 
   EFC39291.1 104 NVLDALQKMSQLTKLDIGMnKLGVKGAKEIGKlKQLRELNIIYNNIG--NEGAEYISQLENLTYLDIACNRMDVEGVKSICKLKQLTDLSIHRNSIEK 199
                  56666777777777888773589999999977346788888887654..44578*********************************99999999999 PP

                  TTTEEEEEGGGGC CS
  PI-TkoII_IV 109 nkreylvefndlr 121
                  +  +yl e+n+l 
   EFC39291.1 200 EGAKYLSELNQLT 212
                  9999999999986 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0      0.02        52     103     124 ..     150     171 ..     135     180 .. 0.88
   2 ?    6.8   0.0    0.0022       5.6     103     125 ..     198     220 ..     180     229 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.02
     DUF4347 103 geaGeafvekLaqltgadvaAs 124
                 g++G +++++L++lt  d+a +
  EFC39291.1 150 GNEGAEYISQLENLTYLDIACN 171
                 578****************976 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0022
     DUF4347 103 geaGeafvekLaqltgadvaAst 125
                 +++G +++++L+qlt+ d+a s+
  EFC39291.1 198 EKEGAKYLSELNQLTKLDIACSD 220
                 468*****************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (292 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       643  (0.0358637); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1736.47
//
Query:       EFC39292.1  [L=432]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       655  (0.036533); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 2436.19
//
Query:       EFC39293.1  [L=310]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (310 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       477  (0.0266049); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1871.07
//
Query:       EFC39294.1  [L=412]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.7e-24   85.0   0.2    7.3e-23   81.4   0.2    2.1  1  FAD_binding_3   FAD binding domain
    1.9e-06   28.0   0.1    3.8e-06   27.0   0.1    1.5  1  NAD_binding_8   NAD(P)-binding Rossmann-like domain
    0.00012   21.4   0.0     0.0033   16.7   0.0    2.2  2  Pyr_redox_3     Pyridine nucleotide-disulphide oxidoreductase
      0.001   18.4   0.0     0.0018   17.6   0.0    1.4  1  Thi4            Thi4 family
      0.001   17.8   0.0      0.003   16.3   0.0    1.8  2  HI0933_like     HI0933-like protein
     0.0015   18.2   0.0     0.0072   15.9   0.0    1.9  2  DAO             FAD dependent oxidoreductase
     0.0046   16.2   0.0      0.011   15.0   0.0    1.6  2  Pyr_redox_2     Pyridine nucleotide-disulphide oxidoreductase
     0.0058   17.2   0.0      0.015   15.8   0.0    1.7  1  Pyr_redox       Pyridine nucleotide-disulphide oxidoreductase
      0.007   15.4   0.0        1.4    7.9   0.0    2.2  2  SE              Squalene epoxidase
  ------ inclusion threshold ------
      0.023   14.0   0.0       0.77    9.0   0.0    2.2  2  Amino_oxidase   Flavin containing amine oxidoreductase
      0.025   14.6   0.0      0.076   13.0   0.0    1.8  2  NAD_binding_9   FAD-NAD(P)-binding
      0.034   13.2   0.0      0.048   12.7   0.0    1.2  1  Filo_VP35       Filoviridae VP35
        0.1   12.6   0.0        0.2   11.6   0.0    1.5  1  NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogen
       0.13   11.3   0.0       0.53    9.3   0.0    1.9  2  Lycopene_cycl   Lycopene cyclase protein
        0.2   11.5   0.1       0.35   10.7   0.1    1.4  1  3HCDH_N         3-hydroxyacyl-CoA dehydrogenase, NAD binding 


Domain annotation for each model (and alignments):
>> FAD_binding_3  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.4   0.2   6.1e-26   7.3e-23       3     328 ..       5     351 ..       3     356 .. 0.73

  Alignments for each domain:
  == domain 1  score: 81.4 bits;  conditional E-value: 6.1e-26
                    EEEEE--SHHHHHHHHHHHHTTHHEEEEESSSSSCCSSS--EEEHHH...HHHHHHTT-HHHHHHHSEECCCCEEEEEEECCCCCEEEEEHH.CHH CS
  FAD_binding_3   3 dVlIVGaGpaGlmlallLseaGvrvvlvekrsttvvlpradglnqrt...mellrqlGledrilaegapnelmgealynelsdtpkaradle.les 94 
                    +V I+GaGp+Gl la+lL++a ++v + e+ s t    +++ l+  +      ++ +Gl +++l++ +++   +++l+ +   ++   +d +  +s
     EFC39294.1   5 KVTIIGAGPSGLCLATLLQQANIQVSVFERDSITLGRDQGGSLDMHSdygQIAIKGAGLYEEFLKMSRVEGEATKILEST--TLKLLFEDGSaQDS 98 
                    799*************************************99988773334579*************9999989998888..23344444432345 PP

                    CST-CEE--HHHHHHH....HHHHHHHHTEEETCSEEEECCEECCCCCCCEEEECCTTEEEEEEEEEEEE--GTT-HHHHHHTGGEEEEEEEEEEE CS
  FAD_binding_3  95 spervtvypqteleri....LvehaeerglqvrfktevesleqdeegvtaevrdketgeeetvrakYlvGaDGgrStvrktlgiefegeetvyeag 186
                    + e+  +++ +e++r+    L  + +  + +v++++ v  +++ e++ + +++ + ++  + v  + lvG+DG++S+vr++   + ++ ++vy ++
     EFC39294.1  99 TTENEDAFSKPEIDRMdlrnLFLN-ALSPGTVEWNKAVDCIKKIESS-EGQYQINFKDGSSHV-TDLLVGCDGAWSKVRSAFTQTKPTYSGVYFIE 191
                    566666666666666521112233.3455778888888755555544.445554333444355.5******************9988888886554 PP

                    E.EEEEEEC-SCCCTTCCEEEEECCTTEE.......EEEECCE.TEEEEEEEEECCE-GGGSCCCHH..HHHHHHHHHHHH.TTSSCEEEEEEEEE CS
  FAD_binding_3 187 v.ldvlfdadlsdiveplvlilsaesrgv.......mviPlen.tlerfyvqvearaekeersekft..eeevkarlreiv.gektldveieevsa 270
                    + l++  ++dl+       +i  + ++++        +++++n +  rfy  +++++e  e++  f+  +e+vk++l e++ g+++   ++ +v  
     EFC39294.1 192 SkLQLDRNDDLA-----RKVIEMTGKGSLfslynnkGLLAQRNsNHIRFYYCLRMDKELVEQTIHFEkgPEVVKQQLLELFnGWDDSLLDFIRVIE 282
                    414444444666.....455666666666677777778888888**************9999887763379*******998457777777666655 PP

                    EEEE.EEEESS.........SEET.TEEE-GGGTEEE-STTSHHHHHHHHHHHHHHHHHHHHHTTSS-G CS
  FAD_binding_3 271 wtva.qrvaek.........yrkg.rvflaGDAaHihpPtgGqGlNtaiqDavnLawkLaavlkGeAke 328
                     +   +++ ++         ++    v ++GDAaH+++P +G+G N+a+ Da++La  L++   G A+e
     EFC39294.1 283 CNDDfSFIKRPlyslppewdWKTQpGVTIIGDAAHVMTPFAGLGANLALLDAHDLAQFLIHGRDGIASE 351
                    55441444432322333333677779*********************************9988888776 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.1   3.1e-09   3.8e-06       1      31 [.       8      38 ..       8      70 .. 0.86

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 3.1e-09
                   EE--SHHHHHHHHHHHCCTEEEEEE-SSSSS CS
  NAD_binding_8  1 IvGaGlsGlvaAylLakagfdvlllekrdrl 31
                   I+GaG sGl++A lL++a+++v ++e+ + +
     EFC39294.1  8 IIGAGPSGLCLATLLQQANIQVSVFERDSIT 38
                   9*************************98764 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.8e-06    0.0033       2      32 ..       8      37 ..       7      39 .. 0.94
   2 ?    2.3   0.0     0.069        83     233     256 ..     136     159 ..     101     181 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.8e-06
  Pyr_redox_3  2 IiGaGPaGlaaaielkkagledylilEkgni 32
                 IiGaGP Gl  a+ l++a++ ++ + E+++i
   EFC39294.1  8 IIGAGPSGLCLATLLQQANI-QVSVFERDSI 37
                 9*******************.799****987 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.069
  Pyr_redox_3 233 aevkeikekeeeykvktedgkkve 256
                   ++k+i+ +e +y+++++dg+++ 
   EFC39294.1 136 DCIKKIESSEGQYQINFKDGSSHV 159
                  578999*************97743 PP

>> Thi4  Thi4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   1.5e-06    0.0018      18      54 ..       4      40 ..       1      51 [. 0.79

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.5e-06
                EEEEEE--SHHHHHHHHHHHHCTTS-EEEEESS.SS-- CS
        Thi4 18 sDvvivGaGssGLtaayylakkpdlkvailers.vspG 54
                  v i+GaG+sGL  a  l ++ +++v ++er  +++G
  EFC39294.1  4 KKVTIIGAGPSGLCLATLLQQA-NIQVSVFERDsITLG 40
                5799***************999.********9613333 PP

>> HI0933_like  HI0933-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.5e-06     0.003       2      32 ..       5      35 ..       4      41 .. 0.92
   2 ?   -3.8   0.0       3.3   3.9e+03      29      46 ..     196     214 ..     194     215 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.5e-06
                 SEEEE--SHHHHHHHHHHHHTT--EEEE-SS CS
  HI0933_like  2 dviviGgGaAGlmaAisaakrgkrVllleka 32
                 +v +iG+G++Gl  A  +++++ +V ++e+ 
   EFC39294.1  5 KVTIIGAGPSGLCLATLLQQANIQVSVFERD 35
                 799**************************86 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 3.3
                  E-SSSSS-HH.HHHCGGGT CS
  HI0933_like  29 lekakklgrK.ilisGgGr 46 
                  l++++ l+rK i ++G+G 
   EFC39294.1 196 LDRNDDLARKvIEMTGKGS 214
                  78999999994579**996 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0     6e-06    0.0072       2      31 ..       6      37 ..       5      98 .. 0.91
   2 ?   -0.1   0.0      0.47   5.6e+02     180     227 ..     148     190 ..     122     243 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 6e-06
                EEEECTSHHHHHHHHHHHHTT..EEEEESSSS CS
         DAO  2 vviiGGGiiGlstAyeLarrg..Vtllekgdi 31
                v iiG+G  Gl+ A  L++++  V ++e+++i
  EFC39294.1  6 VTIIGAGPSGLCLATLLQQANiqVSVFERDSI 37
                89***************999899******965 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.47
                 EEEEEECTEEEEEEEEEEE--GGGHH.HHHTTCTTTSEEEEEEEEEEEE CS
         DAO 180 wgverttpgendaadavVnaaGawsd.llgllkeldlpispvrgqvlvl 227
                 +++ + ++g+ +  d +V + Gaws+  +        +++p+ + v+ +
  EFC39294.1 148 YQI-NFKDGSSHVTDLLVGCDGAWSKvRS---AF--TQTKPTYSGVYFI 190
                 445.3334655444889*******97544...11..2345555555555 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   9.1e-06     0.011       1      38 [.       4      41 ..       4     110 .. 0.72
   2 ?   -2.7   0.0       2.3   2.7e+03     206     236 ..     138     168 ..     128     178 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 9.1e-06
                 CSEEEE--SHHHHHHHHHHHHHTS-EEEEETTHCHHHC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2  1 kdvvviGgGpAGlaaaltlaqagakvtlvelegtclng 38
                 k+v +iG+Gp Gl +a+ l+qa+++v ++e++  +l++
   EFC39294.1  4 KKVTIIGAGPSGLCLATLLQQANIQVSVFERDSITLGR 41
                 57889999999999999999999999999755555544 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.3
                  EEEEEETTEEEEEEETTSCEEEESEEEE-S- CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 206 vkeidgngeklevvledgeeidadlvvvavG 236
                  +k+i++ + +++   +dg++  +dl+v + G
   EFC39294.1 138 IKKIESSEGQYQINFKDGSSHVTDLLVGCDG 168
                  4566666668889999999999999998877 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   1.3e-05     0.015       1      35 [.       5      39 ..       5      47 .. 0.90

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.3e-05
                EEEEECSSHHHHHHHHHHHHTTSEEEEEESSSSSS CS
   Pyr_redox  1 kvvvvGgGyiglElAgalaelgkkVtvversdkll 35
                kv+++G+G +gl lA+ l++ + +V+v+er +  l
  EFC39294.1  5 KVTIIGAGPSGLCLATLLQQANIQVSVFERDSITL 39
                699***************************87665 PP

>> SE  Squalene epoxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0    0.0069       8.2       3      25 ..     161     183 ..     159     205 .. 0.81
   2 !    7.9   0.0    0.0012       1.4     127     167 ..     304     344 ..     284     359 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0069
          SE   3 kltvvcDGifsklRkelsdnkve 25 
                  l v cDG +sk+R ++++ k++
  EFC39294.1 161 DLLVGCDGAWSKVRSAFTQTKPT 183
                 57899************977765 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0012
          SE 127 nekkGlillGDalnmRHPltggGmtvalnDivllskllkpl 167
                 +++ G+ ++GDa  +  P  g G   al D+  l+++l   
  EFC39294.1 304 KTQPGVTIIGDAAHVMTPFAGLGANLALLDAHDLAQFLIHG 344
                 4669***************************9998877554 PP

>> Amino_oxidase  Flavin containing amine oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   0.0   0.00064      0.77       2      23 ..      14      35 ..      13      40 .. 0.94
   2 ?    2.6   0.0     0.053        64     220     255 ..     124     162 ..     116     172 .. 0.84

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00064
                   HHHHHHHHHHHTTEEEEEEESS CS
  Amino_oxidase  2 aGLaaArqLlsaGfdVtvlEar 23
                   +GL+ A+ L++a+ +V+v+E +
     EFC39294.1 14 SGLCLATLLQQANIQVSVFERD 35
                   9*******************86 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.053
                    TTTEEEETSEEEEEEEE..ETTC.EEEEETTSTEEEESE CS
  Amino_oxidase 220 lrgldirlntrVkeikr..egdg.vtvtledgevveaDa 255
                    l+++++  n+ V  ik+  +++g + ++++dg++   D 
     EFC39294.1 124 LSPGTVEWNKAVDCIKKieSSEGqYQINFKDGSSHVTDL 162
                    56799*************955556*********987776 PP

>> NAD_binding_9  FAD-NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   6.4e-05     0.076       2      36 ..       8      37 ..       7      52 .. 0.82
   2 ?   -2.7   0.0       4.3   5.2e+03     121     151 ..     135     165 ..     117     168 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 6.4e-05
  NAD_binding_9  2 ivGaGprGlavlerLlarakkkspleitlfdpsep 36
                   i+GaGp+Gl++++ Ll++a    ++++ +f+++++
     EFC39294.1  8 IIGAGPSGLCLAT-LLQQA----NIQVSVFERDSI 37
                   9********8876.66664....8*******9776 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 4.3
  NAD_binding_9 121 raevvdleeradgqavlladgaslaadaVvL 151
                     + + ++e +++++++  +dg+s+  d +v 
     EFC39294.1 135 VDCIKKIESSEGQYQINFKDGSSHVTDLLVG 165
                    4556778888889999999999998888775 PP

>> Filo_VP35  Filoviridae VP35
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0     4e-05     0.048     194     244 ..      97     147 ..      48     183 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4e-05
                 XXXXXXXXXX----S-HHHHHHHHHCTSSSSSBHHHHHHHHHHHHHHHTCH CS
   Filo_VP35 194 kvlelseetfskpdlsakdlalllydhlpGfntafhilvqvlsklayksGk 244
                 + +   e++fskp++   dl++l+ + l      + + v  + k+    G+
  EFC39294.1  97 DSTTENEDAFSKPEIDRMDLRNLFLNALSPGTVEWNKAVDCIKKIESSEGQ 147
                 334446899******************988889999999999999766665 PP

>> NAD_Gly3P_dh_N  NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00017       0.2       1      32 [.       5      36 ..       5      45 .. 0.93

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00017
                    -EEEE--SHHHHHHHHHHHTTT--EEEE-S-H CS
  NAD_Gly3P_dh_N  1 kiavlGaGswGtalAkvlaenghevrlwvree 32
                    k++++GaG  G  lA++l++++ +v+++ r++
      EFC39294.1  5 KVTIIGAGPSGLCLATLLQQANIQVSVFERDS 36
                    79*************************99986 PP

>> Lycopene_cycl  Lycopene cyclase protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.0   0.00045      0.53       2      30 ..       6      32 ..       5      41 .. 0.84
   2 ?   -0.7   0.0      0.48   5.8e+02     184     209 ..     231     254 ..     104     267 .. 0.76

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00045
  Lycopene_cycl  2 vvviGaGpAglslAarlteakpglkvvli 30
                   v +iGaGp gl lA  l  ++++++v + 
     EFC39294.1  6 VTIIGAGPSGLCLATLL--QQANIQVSVF 32
                   78***************..7777777665 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.48
  Lycopene_cycl 184 kgltFlYalPldsdrllvEeTelask 209
                    +  +F Y l +d++  lvE+T   +k
     EFC39294.1 231 NHIRFYYCLRMDKE--LVEQTIHFEK 254
                    67889999988876..7888865444 PP

>> 3HCDH_N  3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   0.00029      0.35       1      35 [.       5      39 ..       5      61 .. 0.90

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00029
                EEEEE--SCCHHHHHHHHHHTT-EEEEE-S-HHHH CS
     3HCDH_N  1 kvaviGaGtmGagiaavfasagleVvlvdiseeal 35
                kv++iGaG  G  +a+++ +a+++V ++++++ +l
  EFC39294.1  5 KVTIIGAGPSGLCLATLLQQANIQVSVFERDSITL 39
                79**************************9987665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (412 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       524  (0.0292264); expected 358.6 (0.02)
Passed bias filter:                      483  (0.0269396); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.62u 0.36s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 2374.46
//
Query:       EFC39295.1  [L=972]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   1.3e-163  530.7  60.9    1.2e-15   56.9   0.0   21.5 22  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.026   14.2   1.4       0.63    9.7   0.1    2.7  2  DUF2229   CoA enzyme activase uncharacterised domain (DUF2229
      0.085   12.5   0.3        9.3    6.0   0.1    2.9  2  UPF0181   Uncharacterised protein family (UPF0181)
       0.37   11.1   7.3        5.3    7.4   0.0    4.7  5  ESP       Exocrine gland-secreting peptide


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.3   0.2   1.5e-12   6.9e-09       1      49 []      45      93 ..      45      93 .. 0.96
   2 !   35.4   0.0   1.4e-12   6.3e-09       4      48 ..      73     117 ..      72     119 .. 0.96
   3 !   38.6   0.0   1.4e-13   6.3e-10       1      39 [.     120     159 ..     120     161 .. 0.95
   4 !   48.7   0.2   9.9e-17   4.4e-13       1      49 []     146     194 ..     146     194 .. 0.97
   5 !   36.0   1.4     9e-13     4e-09       1      46 [.     196     240 ..     196     243 .. 0.90
   6 !   43.5   0.3   4.3e-15   1.9e-11       1      49 []     220     268 ..     220     268 .. 0.97
   7 !   24.9   0.1   2.7e-09   1.2e-05       1      32 [.     245     276 ..     245     287 .. 0.95
   8 !   20.9   0.3   4.9e-08   0.00022       1      45 [.     296     342 ..     296     347 .. 0.87
   9 !   37.5   0.2   3.1e-13   1.4e-09       1      48 [.     349     397 ..     349     398 .. 0.94
  10 !   30.1   0.1   6.4e-11   2.9e-07       1      35 [.     400     434 ..     400     445 .. 0.92
  11 !    5.2   0.0    0.0038        17      19      39 ..     442     462 ..     434     469 .. 0.81
  12 !    7.7   0.2   0.00063       2.8       1      32 [.     449     501 ..     449     502 .. 0.67
  13 !   30.2   0.6   6.1e-11   2.7e-07       1      49 []     495     540 ..     495     540 .. 0.93
  14 !   17.0   0.0   7.8e-07    0.0035       1      35 [.     565     599 ..     565     608 .. 0.86
  15 !   30.8   0.1     4e-11   1.8e-07       1      49 []     610     658 ..     610     658 .. 0.99
  16 !   24.5   0.1   3.6e-09   1.6e-05       1      35 [.     660     698 ..     660     711 .. 0.85
  17 !   31.0   0.3   3.5e-11   1.6e-07       4      49 .]     692     736 ..     692     736 .. 0.86
  18 !   56.9   0.0   2.7e-19   1.2e-15       1      48 [.     713     760 ..     713     761 .. 0.97
  19 !   23.8   0.0     6e-09   2.7e-05       1      45 [.     763     806 ..     763     807 .. 0.88
  20 !   36.8   0.3   5.4e-13   2.4e-09       1      49 []     787     834 ..     787     834 .. 0.94
  21 !   38.7   0.0   1.4e-13   6.1e-10       1      49 []     836     884 ..     836     884 .. 0.98
  22 !   33.7   0.0   4.9e-12   2.2e-08       1      48 [.     886     933 ..     886     934 .. 0.95

  Alignments for each domain:
  == domain 1  score: 35.3 bits;  conditional E-value: 1.5e-12
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                +r i  ++++k+g +l  +++eLknDk +v+ Av ++g ++ yase+Lr
  EFC39295.1 45 NRLILCKYLRKDGDYLSRIPDELKNDKTLVKIAVMSSGQSIQYASEKLR 93
                67788899***************************************98 PP

  == domain 2  score: 35.4 bits;  conditional E-value: 1.4e-12
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 +v+ av + g +++y+se+L+ D+eiv  A  ++ +al+y++++L
  EFC39295.1  73 LVKIAVMSSGQSIQYASEKLRADREIVYLAACKHEHALKYVDPDL 117
                 6999**************************************998 PP

  == domain 3  score: 38.6 bits;  conditional E-value: 1.4e-13
     DUF4116   1 DrEivleavkkng.salkylseeLknDkeivlkAvkqngt 39 
                 Dr++v+ +v+  g s+l+++seeL+nD eiv+kA++++++
  EFC39295.1 120 DRDFVMTLVSAKGtSVLEFASEELRNDDEIVKKALEICPY 159
                 9*********88769***********************97 PP

  == domain 4  score: 48.7 bits;  conditional E-value: 9.9e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D Eiv++a++++++ +++l++ ++nD++ivl+ +k++++++s+ ++eL+
  EFC39295.1 146 DDEIVKKALEICPYGFQHLPDQFRNDRNIVLETIKRYPNCFSFTCPELQ 194
                 669********************************************97 PP

  == domain 5  score: 36.0 bits;  conditional E-value: 9e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 D+Ei+lea+k+n++    +s++LknD e++  A+k n+  + ya+e
  EFC39295.1 196 DKEIILEAIKRNNY-QPVISSDLKNDVEFMRMAIKLNSELFQYAPE 240
                 9**********633.5568**************************8 PP

  == domain 6  score: 43.5 bits;  conditional E-value: 4.3e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D E++  a+k n++ ++y++e LknDk+++++ ++ n++ ++++s+eL+
  EFC39295.1 220 DVEFMRMAIKLNSELFQYAPECLKNDKQFIMEQIRTNSSTFKHISPELK 268
                 669********************************************97 PP

  == domain 7  score: 24.9 bits;  conditional E-value: 2.7e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlk 32 
                 D+++++e +++n+s +k++s+eLk D++ivl 
  EFC39295.1 245 DKQFIMEQIRTNSSTFKHISPELKDDRDIVLL 276
                 9*****************************96 PP

  == domain 8  score: 20.9 bits;  conditional E-value: 4.9e-08
     DUF4116   1 DrEivlea.vkkngsalky.lseeLknDkeivlkAvkqngtalsyas 45 
                 D+Eiv+ a ++   +++   +seeL  Dke++l+ ++++ t+++y+ 
  EFC39295.1 296 DKEIVKTAlIDYSAFSIMRtVSEELLLDKEFCLELLEIDQTVIDYVR 342
                 9*******666667877777*************************96 PP

  == domain 9  score: 37.5 bits;  conditional E-value: 3.1e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas.eeL 48 
                 D++++++++++n+ +l+++ e+LknD+e vlkA+    ++l+ya  +eL
  EFC39295.1 349 DKDLIMKLIESNPRSLYFAGEDLKNDRECVLKALHYGADILEYATsDEL 397
                 9**********************************999*****996666 PP

  == domain 10  score: 30.1 bits;  conditional E-value: 6.4e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 D+ iv +a++++g +++ ++e+++nD+++vlkA++
  EFC39295.1 400 DKYIVIKAISQYGGNINSVDEKFQNDRDFVLKAIR 434
                 788*******************************8 PP

  == domain 11  score: 5.2 bits;  conditional E-value: 0.0038
     DUF4116  19 lseeLknDkeivlkAvkqngt 39 
                 ++  ++nD+ei+ +A +  g+
  EFC39295.1 442 IPIAFQNDREILEEAFNYFGH 462
                 667799*********987776 PP

  == domain 12  score: 7.7 bits;  conditional E-value: 0.00063
     DUF4116   1 DrEivleavkkngs...................alky..lseeLknDkeivlk 32 
                 DrEi  ea+  +g                     + +   s+e+k+D+e+vl+
  EFC39295.1 449 DREILEEAFNYFGHpeipesmlndrklyltqvkTYGFrlESSEMKRDRELVLE 501
                 78888888888888666666666666666666633333378888888888876 PP

  == domain 13  score: 30.2 bits;  conditional E-value: 6.1e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vle+ k+     +y++e ++ D+eiv ++vk++g+ ++ as+ Lr
  EFC39295.1 495 DRELVLEYSKNL---PNYIPELYSDDREIVYECVKRDGKLIELASKRLR 540
                 99**99999984...66999999***********************998 PP

  == domain 14  score: 17.0 bits;  conditional E-value: 7.8e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 D ++  e+++k++s+l ++ +e+++D+e++l   k
  EFC39295.1 565 DMDFLEEVLRKHPSSLSFFRNEFSRDREFALLSAK 599
                 679***************************97666 PP

  == domain 15  score: 30.8 bits;  conditional E-value: 4e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEivl a k++g+++  ++ ++++D+e++   v +n++ l  aseeL+
  EFC39295.1 610 DREIVLLASKNDGYCIFGCDVSFRSDFEFMFNVVTNNSHLLVLASEELK 658
                 9**********************************************97 PP

  == domain 16  score: 24.5 bits;  conditional E-value: 3.6e-09
     DUF4116   1 DrEivleavkkngs....alkylseeLknDkeivlkAvk 35 
                 D+E+vl+a+k+n +    +l ++s++L+nD  ++l++ k
  EFC39295.1 660 DKELVLHAMKSNEEptldCLPHISDRLRNDYGFILEISK 698
                 9***********999999*****************9855 PP

  == domain 17  score: 31.0 bits;  conditional E-value: 3.5e-11
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++le+ k+  + l  ++e+L+n+keivl A+ +ng +l+y+s ++r
  EFC39295.1 692 FILEISKHIAN-LFWIPENLRNNKEIVLNAMSKNGMNLRYVSLDFR 736
                 67777777655.778**************************97765 PP

  == domain 18  score: 56.9 bits;  conditional E-value: 2.7e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 ++Eivl+a++kng++l+y+s +++nDkeivl Avkq g+a+++as+ L
  EFC39295.1 713 NKEIVLNAMSKNGMNLRYVSLDFRNDKEIVLVAVKQTGDAIKFASKPL 760
                 79*******************************************977 PP

  == domain 19  score: 23.8 bits;  conditional E-value: 6e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 Dr++v  a+ ++ s +++ls+eL+ D++++l+ +++ng  l+ ++
  EFC39295.1 763 DRQVVSAAIPTCTS-FYFLSKELRMDRDFILENIEKNGQLLDAVP 806
                 88888899999755.99*********************9998666 PP

  == domain 20  score: 36.8 bits;  conditional E-value: 5.4e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr+++le ++kng  l  + + +++Dkeiv+kAv + g++l++as++L+
  EFC39295.1 787 DRDFILENIEKNGQLL-DAVPHFQSDKEIVIKAVMNKGNILNRASDDLK 834
                 9*************66.6666**************************97 PP

  == domain 21  score: 38.7 bits;  conditional E-value: 1.4e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr++v+ av++ g+al+ l+e+L+nDkeivl+A  +++ +l +as  Lr
  EFC39295.1 836 DRQVVMAAVTNSGEALTALDEDLRNDKEIVLAATTSHPESLLHASYQLR 884
                 9********************************************9887 PP

  == domain 22  score: 33.7 bits;  conditional E-value: 4.9e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrE++l+avkkn++ + +l ++L+nD ei+ +A++ + + + +as  L
  EFC39295.1 886 DREFILQAVKKNPKLFAHLEHKLQNDEEIATAAIELDVHQIAHASYRL 933
                 9*************************************9999998766 PP

>> DUF2229  CoA enzyme activase uncharacterised domain (DUF2229)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.1     0.017        76      90     168 ..     187     261 ..     174     296 .. 0.64
   2 ?    9.7   0.1   0.00014      0.63     101     172 ..     789     871 ..     773     925 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.017
     DUF2229  90 eynCpivqglpeviknnleeeikllspvldle.dkk.elakqlleelgiskkeikkAvekAleaqkaf.keelrkkgeelle 168
                 +++Cp  q   e+i +++  ++++++pv++ + +++ e+++ ++   +++ + + + + + l++ k+f  e++r  + ++++
  EFC39295.1 187 SFTCPELQNDKEIILEAI--KRNNYQPVISSDlKNDvEFMRMAI---KLNSE-LFQYAPECLKNDKQFiMEQIRT-NSSTFK 261
                 789***************..689999****99766645555333...33333.3333334455555552333333.334444 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00014
     DUF2229 101 eviknnleeeikllspvldle.dkkelakqlle..........elgiskkeikkAvekAleaqkafkeelrkkgeelleelee 172
                 ++i +n+e++ +ll+ v +++ dk+ + k++++          +l+i+++ + +Av +  ea++a +e+lr+ +e +l+++++
  EFC39295.1 789 DFILENIEKNGQLLDAVPHFQsDKEIVIKAVMNkgnilnrasdDLKIDRQVVMAAVTNSGEALTALDEDLRNDKEIVLAATTS 871
                 567778899999***9****9666667777775587777777788***************************99888885433 PP

>> UPF0181  Uncharacterised protein family (UPF0181)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.1    0.0021       9.3      28      45 ..      79      96 ..      73      98 .. 0.91
   2 ?    3.2   0.0     0.015        69      21      45 ..     838     862 ..     835     864 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0021
     UPF0181 28 mssgeAIalVAqelReeh 45
                mssg+ I+  +++lR++ 
  EFC39295.1 79 MSSGQSIQYASEKLRADR 96
                9**************975 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.015
     UPF0181  21 qeLmaqGmssgeAIalVAqelReeh 45 
                 q  ma   +sgeA     + lR+++
  EFC39295.1 838 QVVMAAVTNSGEALTALDEDLRNDK 862
                 67899999**************976 PP

>> ESP  Exocrine gland-secreting peptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.016        70      20      41 ..     203     224 ..     199     261 .. 0.76
   2 ?    7.4   0.0    0.0012       5.3      29      72 ..     262     304 ..     253     318 .. 0.88
   3 ?   -3.7   0.0       3.3   1.5e+04      32      47 ..     655     670 ..     652     686 .. 0.68
   4 ?   -2.3   0.0       1.2   5.6e+03      22      22 ..     729     729 ..     707     771 .. 0.50
   5 ?   -0.1   0.3      0.26   1.1e+03      33      74 ..     857     907 ..     845     954 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.016
                 XXXXXXXXXXXXXXXXXXXXXX CS
         ESP  20 vLtqTqkestisAdhktnfkiv 41 
                 ++++++ ++ is+d+k++ + +
  EFC39295.1 203 AIKRNNYQPVISSDLKNDVEFM 224
                 6899999***********9864 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0012
                 XXXXXXXXXXXXXXX---TTHHHHHHTTHHHHSSSTHHHHHHHH CS
         ESP  29 tisAdhktnfkivldkidcqnireaiekvlcasdqdktlledfa 72 
                 +is ++k++ +ivl  + ++++  a+e+v + s++dk++++  +
  EFC39295.1 262 HISPELKDDRDIVLLTLYMREFD-AMEMVGKNSKKDKEIVKTAL 304
                 79************999999998.***************99665 PP

  == domain 3  score: -3.7 bits;  conditional E-value: 3.3
                 XXXXXXXXXXXX---T CS
         ESP  32 Adhktnfkivldkidc 47 
                  ++k++++ vl+ +++
  EFC39295.1 655 EELKDDKELVLHAMKS 670
                 5667777777765543 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 1.2
                 X CS
         ESP  22 t 22 
                  
  EFC39295.1 729 R 729
                 1 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 0.26
                 XXXXXXXXXXX---TT.........HHHHHHTTHHHHSSSTHHHHHHHHTT CS
         ESP  33 dhktnfkivldkidcq.........nireaiekvlcasdqdktlledfana 74 
                 d++++++ivl  + +          ++r + e +l+a +++ +l+      
  EFC39295.1 857 DLRNDKEIVLAATTSHpesllhasyQLRTDREFILQAVKKNPKLFAHLEHK 907
                 677888888887777777788887788888888888888888888765433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (972 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       711  (0.0396564); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.84u 0.34s 00:00:01.18 Elapsed: 00:00:00.53
# Mc/sec: 5499.63
//
Query:       EFC39296.1  [L=1563]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      1e-14   55.1   0.0    2.5e-14   53.9   0.0    1.6  1  OTU            OTU-like cysteine protease
    5.5e-07   29.9  40.9    0.00051   20.3   9.3    3.6  3  EGF_2          EGF-like domain
     0.0028   17.6   0.0       0.67   10.1   0.0    3.8  3  NHL            NHL repeat
     0.0031   17.0   7.8      0.066   12.7   0.1    3.4  3  Peptidase_C65  Peptidase C65 Otubain
  ------ inclusion threshold ------
      0.014   14.3   2.7      0.024   13.5   2.7    1.3  1  LMBR1          LMBR1-like membrane protein
      0.027   13.5   0.2      0.027   13.5   0.2    4.2  3  ASC            Amiloride-sensitive sodium channel
      0.041   13.5   0.1         13    5.3   0.0    3.3  3  SGL            SMP-30/Gluconolactonase/LRE-like region
      0.043   12.3   0.0      0.068   11.6   0.0    1.2  1  TrkH           Cation transport protein
      0.099   13.0  31.1      0.095   13.0   8.5    3.6  3  EGF            EGF-like domain
        1.1    9.0   4.3        2.7    7.8   4.3    1.6  1  MSL1_dimer     Dimerisation domain of Male-specific-Lethal 1
        1.4    9.3  20.9       0.11   12.8   2.3    3.0  2  DUF3446        Early growth response N-terminal domain


Domain annotation for each model (and alignments):
>> OTU  OTU-like cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.9   0.0   1.5e-17   2.5e-14       1     127 []     884    1000 ..     884    1000 .. 0.84

  Alignments for each domain:
  == domain 1  score: 53.9 bits;  conditional E-value: 1.5e-17
                  --SS-HHHHHHHHCCCSS.SHCCHHHHHHHHHCHHHHHHTSSHHCCHHHHCCHHH.HHHHTTSTTHHHHHHHHHHHHHHCTS-EEEETTSSSSEEEE CS
         OTU    1 rgDGnCLlravsqqlwgvsdelrkakvseLreklaeylrehseelelfleeeeeg.ylkeiektaawggeleifalahiLrrpIiVlksesgeelvg 96  
                  +gDGnC +r+vs+ql+     +++ +++++r+  +ey++ + +++++f+ +e  + y+k ++k+ +wg++l ++ ++  ++++I V      ++l++
  EFC39296.1  884 TGDGNCQFRSVSDQLY-----GDQTQYQKIRQGAVEYMITNPDMFSPFVCDEPFEdYCKTMKKDTEWGDNLTLQSISLAFNVNIRV------HQLGQ 969 
                  59*************9.....888999*********************98875556******************************......34444 PP

                  -TT-EEE--TTS-GGGS-SS-EEEEEETTEE CS
         OTU   97 lkfegvylplekdkslclkypihlyylgeHy 127 
                   +f  v+ +    + + l+y+    y + H+
  EFC39296.1  970 PSFDIVNYNQPESRLIQLSYHMGEHYNSVHF 1000
                  4555555666777778888888666666666 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4  10.1   2.2e-05     0.036       5      32 .]     696     722 ..     690     722 .. 0.90
   2 !   20.3   9.3   3.2e-07   0.00051       6      32 .]     730     756 ..     727     756 .. 0.92
   3 !    6.9   5.5    0.0051       8.4       7      31 ..     772     795 ..     767     795 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 2.2e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +e C+ +G Cvn+   C C+ g++G  C
  EFC39296.1 696 SEVCSKRGNCVNFD-TCACQEGFFGSEC 722
                 688********999.9************ PP

  == domain 2  score: 20.3 bits;  conditional E-value: 3.2e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C ++G+C+ ++G+C+C+++y+G++C
  EFC39296.1 730 SPCLNGGSCIPETGNCSCPTSYSGAKC 756
                 46********999************** PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0051
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGkt 31 
                  Cgg G+C  +   C+C+ g +G++
  EFC39296.1 772 VCGGKGSCTGFD-FCSCSVGSFGDK 795
                 6********555.7*********85 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   0.00041      0.67       1      23 [.     523     545 ..     523     550 .. 0.85
   2 ?    2.4   0.0      0.12   1.9e+02       4      18 ..     584     599 ..     582     602 .. 0.93
   3 ?   -1.3   0.0       1.7   2.8e+03      13      25 ..     653     665 ..     652     667 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00041
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 +n P +++ +snGd++V+D+ n+
  EFC39296.1 523 LNLPYDLSFNSNGDLFVCDYQNS 545
                 5678899************9887 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.12
                 EEEEEEE.TTTEEEEE CS
         NHL   4 PhGvavd.snGdiyVa 18 
                 P ++av+ ++Gd+++a
  EFC39296.1 584 PVSIAVSkKSGDLFIA 599
                 99***********998 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 1.7
                 TEEEEEECCCTEE CS
         NHL  13 GdiyVaDsenhrv 25 
                 G+iy +D  ++ +
  EFC39296.1 653 GQIYLSDASTNLI 665
                 9******777766 PP

>> Peptidase_C65  Peptidase C65 Otubain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.6   0.0    0.0028       4.6      41      56 ..     879     894 ..     859     899 .. 0.77
   2 !   12.7   0.1     4e-05     0.066     149     208 ..     915     971 ..     906    1031 .. 0.77
   3 ?   -2.6   3.1       1.8   2.9e+03      72     135 ..    1196    1256 ..    1188    1259 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0028
                    EEE-B--SSTHHHHHH CS
  Peptidase_C65  41 siRrvrgDGnCfyRaf 56 
                    ++++v gDGnC +R++
     EFC39296.1 879 YLKKVTGDGNCQFRSV 894
                    6899**********98 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 4e-05
                    HHHHTHHHHGGGS-TT--HHHHHHHHTSSTT--B-HHHHHHHHHHTT--EEEEESSSSGB CS
  Peptidase_C65 149 elkthadeyepFldelstveeFceqevepvnkEaDnvqitaLaealgvkvrVeyldrsve 208
                    ++ t+ d ++pF+ + +  e++c++  ++  +  Dn+ ++ ++ a++v++rV  l +  +
     EFC39296.1 915 YMITNPDMFSPFVCD-EPFEDYCKTM-KKDTEWGDNLTLQSISLAFNVNIRVHQLGQP-S 971
                    777999*********.9*******98.7778889********************9954.2 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.8
                     HHHHHHHHHHHHHHHHH.HTT--HHHHHHHHHHHHHHHHHHHTTSS-HH....HHHHHHTSHHHH CS
  Peptidase_C65   72 evsrikerveklkeale.slgfdeevvedfleaflellkkiekkteeseekaeellkafneqees 135 
                      ++r+++  +k++e+l+    +++ +v++ ++  +e +kk+e+   +s+    el+++ ++q++s
     EFC39296.1 1196 LTKRERKD-KKQREKLSkVEAIKHRTVQNNTDFDEEAIKKMEQPVPSSSM---ELIEQQQKQHHS 1256
                     34444444.444445542667999999***************99988863...566666665555 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   2.7   1.5e-05     0.024     195     384 ..    1179    1345 ..    1117    1353 .. 0.59

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.5e-05
       LMBR1  195 ksdldeelkklyfeaaklntekeeaereledllkevkklrksisesdp.lr.kyleeilkkvPeeiaeklksnenkteeslaklekqlikalqkrer 289 
                  +s+ ++ +++ +++++kl+ ++e + ++ +++l++v++++ ++ ++++ +  + ++++ + vP+               +l++   q+++  +++  
  EFC39296.1 1179 TSTVEDSTSSSKTKEKKLT-KRERKDKKQREKLSKVEAIKHRTVQNNTdFDeEAIKKMEQPVPSSSM------------ELIEQ--QQKQHHSHQGG 1260
                  6777888999999*****9.55555788888999999999999999965554666666666666333............33333..22222222222 PP

       LMBR1  290 tekqwkrllekalelediiknksskekefkssessrrgefakqgklkltptleyywaklllplv.llilsiilvllsiiiilseltkllekpplsl 384 
                   +   ++ + ++       ++k+++ek+  +++++++++ +k  +    p +++y  + l ++v ++ ++i+ +  s i+      + l +p+ sl
  EFC39296.1 1261 GKSSGDQTIVEM------QEDKNKAEKKKDKKDKKDKKKKKKVKHCCKLP-TKWYHIITLVGWVvMIGFCIWYIYNSTINYY----ETLANPTTSL 1345
                  222333333333......22222222222222222222221111222233.4444444444444044444444444444444....4555666555 PP

>> ASC  Amiloride-sensitive sodium channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.3       2.2   3.6e+03      95      99 ..     844     848 ..     787     986 .. 0.60
   2 ?   10.9  19.5   9.6e-05      0.16     126     263 ..    1218    1465 ..    1059    1484 .. 0.72
   3 ?   13.5   0.2   1.6e-05     0.027     386     432 ..    1488    1534 ..    1466    1540 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.2
                 XXXXX CS
                 xxxxx RF
         ASC  95 eekik 99 
                  +++k
  EFC39296.1 844 YNNKK 848
                 11111 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 9.6e-05
                  X..............................................................XXXXXXXXXXXXXXXXXXXXXX............ CS
                  x..............................................................xxxxxxxxxxxxxxxxxxxxxx............ RF
         ASC  126 r..............................................................nlkfakaaksskflrelghele............ 148 
                  +                                                              + k++k++k +k++++ +   +            
  EFC39296.1 1218 HrtvqnntdfdeeaikkmeqpvpsssmelieqqqkqhhshqgggkssgdqtivemqedknkaeKKKDKKDKKDKKKKKKVK---Hccklptkwyhii 1311
                  022233444555555556667777777777777777888889999998888888876654433233333333333333333...1445778888888 PP

                  ......XXXXXXXXXX.X.XXX..XXXXXXXX........................................XXXXXXXXXXXXXXXXXXXX..XXX CS
                  ......xxxxxxxxxxxxxxxx..xxxxxxxx........................................xxxxxxxxxxxxxxxxxxxxxxxxx RF
         ASC  149 ......dlileCsfngekdpCs..kdfteilt........................................eyGnCytfnsnkeknltssrkgags 197 
                         +i  C ++  + + +  +    +l                                         ++ nCy +n  ++  +++++  +g 
  EFC39296.1 1312 tlvgwvVMIGFCIWYIYNSTINyyE----TLAnpttslsyvaklpmafpngsdvsynetgrlieekrinqlgSDFNCYVINNSTTDPFSTHK--TGY 1402
                  8888878888888865332443331....22234455669999999999999999999999999999999999999*****88888888888..*** PP

                  XXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ASC  198 ryglslvlnvqqeeylptseeseaaGfkvlihdpdevpdidkegvsvppgtetsigikpkkikrlp 263 
                  + +++l++ +   +++  +      G ++++h+p++ pd   e+ +++p + +++ +++ ++krl+
  EFC39296.1 1403 MGSIQLYFTITRPDED-VTG--ARIGLQISFHEPGTDPDLLAETNYAMPDMDNVFMLTKVYTKRLK 1465
                  *******977655542.333..389********************************999999996 PP

  == domain 3  score: 13.5 bits;  conditional E-value: 1.6e-05
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ASC  386 eykrenlakvevyfeelnyerleeseaysltdllsdlGGllGLflGa 432 
                    +++  + +++ +++l  + + e  + +++ ll+d+ G+lGL +G+
  EFC39296.1 1488 VGNDDDGVYITIAYSSLVQNNIVEIITGTIEGLLGDIAGILGLTMGI 1534
                  33445679**************************************8 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0         2   3.3e+03      11      40 ..     120     149 ..     113     187 .. 0.65
   2 ?    4.1   0.0     0.018        30      10      88 ..     371     468 ..     367     503 .. 0.64
   3 ?    5.3   0.0     0.008        13      37     144 ..     579     682 ..     529     689 .. 0.71

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2
         SGL  11 egaLlwvDilgqrihrldpatgketvldtp 40 
                 +++L++++   ++i ++d+++++ t +  +
  EFC39296.1 120 NNSLFFSETGFNKIRKFDLSSKQVTNIAGN 149
                 566666666666666666666666655444 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.018
         SGL  10 eegaLlwvDilgqrihrldpatgketv................ldtpe......svGaiaprkd.grlvvasksglalldlasgeletlade.eedekp 84 
                 e+ +L++ D l+ ri ++d++t+  ++                +   +       +G +++  + + +++  + + ++ld++s++++ +a + +e++++
  EFC39296.1 371 EDTSLIFLDSLNYRIRKIDLHTNLVQTmagsgdigydngaastA---SfthptaLIGDTVL--GpNVFLIYDSFKHRILDTSSRTVSDFALPiFESQYQ 464
                 6889***********************66666666555553331...12211123333333..236666666666677788888888777775555555 PP

         SGL  85 llrf 88 
                  +r+
  EFC39296.1 465 GVRS 468
                 5554 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.008
         SGL  37 ldtpesvGaiaprkdgrlvvasksglalldlasgeletladeeedekpllrfNDgvvdpdGrlwfGtmgdeeakgeevgalyrldpdgklervlddlti 135
                 +++ ++v++++ +k+g l +a++++++++d ++ ++et+a +  ++ + +  N   +d++ +  +G  ++  ++ +  g++y  d+++ l r l+ +  
  EFC39296.1 579 ANIVKPVSIAVSKKSGDLFIAQRRTIRRVDSSTLQIETIAGSL-NR-DGIIENGEDIDARSARLIGIEQIILDELT--GQIYLSDASTNLIRRLTPVCD 673
                 5555699*****888*************************995.33.67777877888888778887777777777..777777777665555555555 PP

         SGL 136 pNGlawspd 144
                 +   a+++d
  EFC39296.1 674 SSNYALKQD 682
                 544555555 PP

>> TrkH  Cation transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   4.1e-05     0.068     120     180 ..    1274    1333 ..    1177    1365 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.1e-05
        TrkH  120 rgsaflylseaqkeelggkelrslselikilvvyyvgleilafvllvvliytakaysevvd 180 
                    +++ ++++ +k+ +++k+ +++++ +k+ ++ y ++++++ v++ + ++    y++ ++
  EFC39296.1 1274 EDKNKAEKKKDKKDKKDKKKKKKVKHCCKLPTKWYHIITLVGWVVM-IGFCIWYIYNSTIN 1333
                  57888999*************************************9.99998888988883 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   2.4   0.00014      0.23       6      31 ..     699     720 ..     691     721 .. 0.92
   2 ?   13.0   8.5   5.8e-05     0.095       1      31 [.     727     754 ..     727     755 .. 0.94
   3 ?   -0.6   4.6       1.1   1.7e+03       4      31 ..     769     794 ..     767     795 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00014
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G Cv+      tC C+eG++G+
  EFC39296.1 699 CSKRGNCVNFD----TCACQEGFFGS 720
                 *******9999....*********96 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 5.8e-05
                 GCSTTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 C+  pC+ngG C   + ++ +C Cp+ y+G+
  EFC39296.1 727 CTVSPCLNGGSC--IP-ETGNCSCPTSYSGA 754
                 8889********..99.************96 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 1.1
                 TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   4 np..CsngGtCvdtgrggytCiCpeGytGk 31 
                 np  C + G C     g   C C++G +G+
  EFC39296.1 769 NPtvCGGKGSC----TGFDFCSCSVGSFGD 794
                 77789999999....7799*******8886 PP

>> MSL1_dimer  Dimerisation domain of Male-specific-Lethal 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   4.3    0.0017       2.7      17      29 ..    1244    1256 ..    1243    1258 .. 0.88

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0017
  MSL1_dimer   17 LdLIEQQQqqLqn 29  
                  ++LIEQQQ+q ++
  EFC39296.1 1244 MELIEQQQKQHHS 1256
                  69********887 PP

>> DUF3446  Early growth response N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5  10.9      0.46   7.6e+02      35      76 ..    1067    1106 ..    1054    1114 .. 0.51
   2 ?   12.8   2.3   6.7e-05      0.11      14      61 ..    1143    1191 ..    1131    1199 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.46
     DUF3446   35 sspsssssssssssssssspslscsvaaqqssel.ehiYsaaP 76  
                  ss++ss+ss s  +s s+s++   sv +++s el + ++s  P
  EFC39296.1 1067 SSSASSTSSNSKKNSKSQSSNS--SVGSSKSHELqNTAFS-SP 1106
                  3444445555555555555553..3323333343144555.44 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 6.7e-05
     DUF3446   14 slwaee.llslvsglvgvanppsspsssssssssssssssspslscsva 61  
                  ++++ e ++ ++  l + +npp+s+ s +  sssss s+   s+s+s +
  EFC39296.1 1143 NNFNTEmVIGILLELGSESNPPPSSNSNTIGSSSSSTSTVEDSTSSSKT 1191
                  677888899**99999999999888887777777777777777777663 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1563 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2419  (0.134921); expected 358.6 (0.02)
Passed bias filter:                      580  (0.0323498); expected 358.6 (0.02)
Passed Vit filter:                       117  (0.00652574); expected 17.9 (0.001)
Passed Fwd filter:                        42  (0.00234257); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 1.24u 0.40s 00:00:01.64 Elapsed: 00:00:00.55
# Mc/sec: 8529.08
//
Query:       EFC39297.1  [L=706]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.3e-28   94.8  12.4      3e-07   30.1   0.1    6.7  7  NHL           NHL repeat
    8.1e-14   51.8   0.5    1.6e-13   50.8   0.5    1.5  1  BTB           BTB/POZ domain
     0.0028   17.3   0.1        2.2    7.8   0.1    3.9  2  SGL           SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
      0.021   15.0   2.5         22    5.4   0.1    5.0  6  Arylesterase  Arylesterase
      0.034   14.2   0.6      0.034   14.2   0.6    1.9  2  YqzH          YqzH-like protein


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   0.1   2.5e-08   8.8e-05       1      27 [.      35      62 ..      35      63 .. 0.92
   2 !   21.0   0.0   6.5e-08   0.00023       1      27 [.      93     120 ..      93     121 .. 0.96
   3 ?   -1.8   0.1       1.1     4e+03      14      25 ..     165     176 ..     165     178 .. 0.81
   4 !   30.1   0.1   8.4e-11     3e-07       1      27 [.     209     236 ..     209     237 .. 0.96
   5 !   13.7   0.1   1.4e-05     0.049       1      25 [.     263     288 ..     263     290 .. 0.93
   6 !   10.2   0.0   0.00018      0.63       7      27 ..     327     348 ..     323     349 .. 0.93
   7 ?   -0.6   0.0      0.47   1.7e+03      13      21 ..     606     614 ..     605     617 .. 0.86

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 2.5e-08
                BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL  1 fnyPhGvavd.snGdiyVaDsenhrvqv 27
                +++P Gvav+  ++d+y+aD++nh++++
  EFC39297.1 35 LSSPYGVAVNpYSNDVYIADYRNHCIRK 62
                56789*********************86 PP

  == domain 2  score: 21.0 bits;  conditional E-value: 6.5e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P +v++  +n ++y+aD+ nhr+++
  EFC39297.1  93 LNCPLSVSIHpKNEELYIADYSNHRIRK 120
                 79************************97 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 1.1
                 EEEEEECCCTEE CS
         NHL  14 diyVaDsenhrv 25 
                 diy+ D+ n+ +
  EFC39297.1 165 DIYIIDFVNNKI 176
                 79****888877 PP

  == domain 4  score: 30.1 bits;  conditional E-value: 8.4e-11
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n P+G+  + ++Gd+y+aDs+nhrv++
  EFC39297.1 209 LNGPSGLDFNpTTGDVYIADSNNHRVRK 236
                 799***********************86 PP

  == domain 5  score: 13.7 bits;  conditional E-value: 1.4e-05
                 BSSEEEEEEE.TTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrv 25 
                 +nyP +v+ +  +  iyV+D+ n+r+
  EFC39297.1 263 LNYPYDVSFCtRGQIIYVTDRSNNRI 288
                 79999*****99999**********9 PP

  == domain 6  score: 10.2 bits;  conditional E-value: 0.00018
                 EEEE.TTTEEEEEECCCTEEEE CS
         NHL   7 vavd.snGdiyVaDsenhrvqv 27 
                 +av  +nGd+y +D++n+r+++
  EFC39297.1 327 IAVHaKNGDVYFSDFGNNRIRK 348
                 79999***************97 PP

  == domain 7  score: -0.6 bits;  conditional E-value: 0.47
                 TEEEEEECC CS
         NHL  13 GdiyVaDse 21 
                 +diyV D+e
  EFC39297.1 606 DDIYVIDTE 614
                 79*****87 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.8   0.5   4.5e-17   1.6e-13       3     108 ..     558     663 ..     556     666 .. 0.87

  Alignments for each domain:
  == domain 1  score: 50.8 bits;  conditional E-value: 4.5e-17
                 HHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST...TTTTCCCE....EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHH CS
         BTB   3 elresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk...eieessvs....eielddvepeafealLefiYtgeleitseenleelLaaadll 94 
                  l++ ++ +D+t+++g +kef+ahk +La+ Spy +alf+s+   ++     +    +i+ ++++ +  e++L+++Y g ++++ +  +++ L + + +
  EFC39297.1 558 TLFNDKATSDITIKTG-TKEFYAHKTILASNSPYYEALFNSGfeyQDL----KddiyVIDTEEFSEDLHEIVLKYCY-GVFDVS-SVPINQALPLFKCF 649
                 689999**********.7************************754333....23345899999999999********.789996.99************ PP

                 T-HHHHHHHHHHHH CS
         BTB  95 qiprlkkaceeflk 108
                  ++++k+++ ++l 
  EFC39297.1 650 ALYDVKEMIDYYLN 663
                 *****999998886 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.025        90     134     210 ..      36     121 ..      30     132 .. 0.48
   2 !    7.8   0.1   0.00062       2.2     132     168 ..     208     242 ..     203     307 .. 0.65

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.025
         SGL 134 tipNGlawspdgktlYlaDsltrkiwayd.vdaeggklsnrrvf.adlkkge......gepDGlavDa.eGnvwvAvwgggkvvrf 210
                 + p G+a++p ++ +Y+aD ++++i +++ +d + +++    v  + ++ g       + p ++ +   + ++++A +++++++++
  EFC39297.1  36 SSPYGVAVNPYSNDVYIADYRNHCIRKVSaLDNKITTIAGTGVAgYSGDGGLalhaqlNCPLSVSIHPkNEELYIADYSNHRIRKI 121
                 55566666666666666666666666654133333333333333333333334444433344444444444444444444444444 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.00062
         SGL 132 dltipNGlawspdgktlYlaDsltrkiwaydvdaegg 168
                 +l+ p Gl ++p +  +Y+aDs ++++ ++++++  g
  EFC39297.1 208 QLNGPSGLDFNPTTGDVYIADSNNHRVRKVNCKS--G 242
                 678899***********************99953..2 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.1     0.006        22      50      78 ..      32      60 ..      12      68 .. 0.85
   2 ?    2.7   0.0     0.042   1.5e+02      36      78 ..      76     118 ..      62     123 .. 0.82
   3 ?   -0.2   0.1      0.34   1.2e+03      52      80 ..     150     178 ..     146     182 .. 0.87
   4 ?    1.0   0.0      0.14     5e+02      52      78 ..     208     234 ..     203     240 .. 0.86
   5 ?   -1.4   0.0      0.78   2.8e+03      63      78 ..     273     288 ..     261     291 .. 0.77
   6 ?   -4.0   0.0         5   1.8e+04      53      76 ..     321     344 ..     318     346 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.006
  Arylesterase 50 asglssanGInidadkkyiyvadilresi 78
                   ++lss+ G+ +++    +y+ad  ++ i
    EFC39297.1 32 EAKLSSPYGVAVNPYSNDVYIADYRNHCI 60
                  4679*******************988876 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.042
  Arylesterase  36 tavvYyspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   t+v  ys++      ++l+ +  + i +++  +y+ad  ++ i
    EFC39297.1  76 TGVAGYSGDGGLALHAQLNCPLSVSIHPKNEELYIADYSNHRI 118
                   55666777777777788999999***************99988 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.34
  Arylesterase  52 glssanGInidadkkyiyvadilresihv 80 
                   +l+++  ++i +    iy+ d ++++i +
    EFC39297.1 150 QLYFPQCVKIHPITFDIYIIDFVNNKIRR 178
                   6899999999999999*********9965 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.14
  Arylesterase  52 glssanGInidadkkyiyvadilresi 78 
                   +l+ + G+ +++    +y+ad+ ++ +
    EFC39297.1 208 QLNGPSGLDFNPTTGDVYIADSNNHRV 234
                   577899***************999987 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 0.78
  Arylesterase  63 adkkyiyvadilresi 78 
                   +  ++iyv+d  ++ i
    EFC39297.1 273 TRGQIIYVTDRSNNRI 288
                   56789****9988877 PP

  == domain 6  score: -4.0 bits;  conditional E-value: 5
  Arylesterase  53 lssanGInidadkkyiyvadilre 76 
                   +ss+  I + a++  +y +d  ++
    EFC39297.1 321 ISSPCQIAVHAKNGDVYFSDFGNN 344
                   677788888888888887776555 PP

>> YqzH  YqzH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.2       3.2   1.1e+04      34      54 ..     417     438 ..     414     439 .. 0.61
   2 ?   14.2   0.6   9.6e-06     0.034      22      61 ..     592     631 ..     578     633 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3.2
        YqzH  34 Lveriq.ekkkeqedeDlyeiv 54 
                 L++ i  +++++ e  D ye+v
  EFC39297.1 417 LIDSIMyQQYHDSEWFDKYELV 438
                 5555542566666667888877 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 9.6e-06
        YqzH  22 elmplseeeqkeLveriqekkkeqedeDlyeiveDivYdy 61 
                 e ++ s +e + L++ i    +e+  eDl+eiv   +Y+ 
  EFC39297.1 592 EALFNSGFEYQDLKDDIYVIDTEEFSEDLHEIVLKYCYGV 631
                 67788999****************************9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (706 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.32s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 4079.18
//
Query:       EFC39298.1  [L=490]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      8e-08   32.6   0.3    2.4e-07   31.0   0.3    1.8  1  MACPF     MAC/Perforin domain


Domain annotation for each model (and alignments):
>> MACPF  MAC/Perforin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.3   1.4e-11   2.4e-07      23     209 .]     149     313 ..     146     313 .. 0.83

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 1.4e-11
                 EEEEEEEEEEEEEEES--....B-HHHHHHHHTS-SS--SSTHHH.HHHHHHHH-SEEEEEEEEEEEEEEEEEEEHHHHHHTT--HHHHHHHHHHHHTS CS
       MACPF  23 liiskskcslyqftlkrsnklklseeFlkalneLpsnydsaaedtpyieffekYGTHvitsvtlGGkivyvlkldkeeveklkkkkedclsasagasin 121
                 l+i+ ++ ++++ t++  +++++++eF+  +  Lp ++d +     y++++ ++G  ++t++ +GG i+ ++ +++++   ++ +  d l+ ++  si 
  EFC39298.1 149 LFIADIQKQYFTHTVSL-STIQVTDEFQMIIDLLPYEMDTDL----YMQVITSFGDSIATNIVYGGVIDLTTSVKSCYNDPSMLSYLD-LELQL--SI- 238
                 66777777788888855.599*****************9999....************************************999999.66665..34. PP

                 -SHHHHHHHHHHHHTT-SS-HHHH---EEEEEESS-GGG----HHHHHHHHHHTTTS-EEEEEEEEEGGGGS-TT-HHHHHHHHHHHH CS
       MACPF 122 gkvslkgkkknssetkekksssqesessktlviGGepeseddksktyseWaesvkenpmpIklelvPisellkeeekkeslkkaleeY 209
                      +     +  ++  + +  +++  ++++ GG+p     + ++ +e  ++  +np+p+k+e  Pi   +++ +k+ ++k  +++Y
  EFC39298.1 239 -----DDQ---TDTSSLPNGYIRYHKVAQLDIVGGNP-----QISSKRERVSTFASNPVPVKFETIPIWRAFPDGPKQANMKIIYNNY 313
                 .....222...2333334455667999*********9.....4456677789999**********************99999877777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (490 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       847  (0.0472419); expected 358.6 (0.02)
Passed bias filter:                      659  (0.0367561); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.37s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 2805.76
//
Query:       EFC39299.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.8e-07   31.1   3.4     0.0059   17.4   0.2    3.4  3  WD40         WD domain, G-beta repeat
    3.2e-07   30.5   0.0      0.018   15.3   0.0    3.4  3  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
     0.0024   16.9   2.8       0.97    8.3   0.1    2.8  3  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
  ------ inclusion threshold ------
      0.019   14.6   0.1       0.68    9.5   0.0    2.1  2  CNH          CNH domain
      0.071   13.0   0.3          2    8.4   0.0    3.0  3  BBS2_N       Ciliary BBSome complex subunit 2, N-terminal
       0.11   11.8   3.9        2.2    7.6   0.1    2.9  3  WD40_like    WD40-like domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.2      0.78   2.3e+03      13      35 ..      15      36 ..       2      38 .. 0.66
   2 !   12.3   0.0     8e-05      0.24       6      34 ..     189     218 ..     184     223 .. 0.79
   3 !   17.4   0.2     2e-06    0.0059       2      37 ..     228     266 ..     227     267 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.78
                EEEEEEETTSSEEEEEETTSEEE CS
        WD40 13 vtslafspdgawlasGsdDgtvr 35
                +   af++d + ++ G+ D++ +
  EFC39299.1 15 ILFAAFNQDCSCVSVGT-DCSYK 36
                55556888888888888.88755 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 8e-05
                 EEESS.SSEEEEEEETTSSEEEEEETTSEE CS
        WD40   6 tltGH.ssvtslafspdgawlasGsdDgtv 34 
                  +++H s+v+ ++f++dg++la++s +gtv
  EFC39299.1 189 FIKAHkSDVSIIQFNQDGTMLATASGKGTV 218
                 4689*888*9999*********88656665 PP

  == domain 3  score: 17.4 bits;  conditional E-value: 2e-06
                 EEEEEEE.SS.SS.EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   2 qclrtlt.GH.ss.vtslafspdgawlasGsdDgtvriW 37 
                 ++l+tl+ G     ++s++fs+d+++++ +sd+gtv+++
  EFC39299.1 228 ELLHTLRrGStAArIYSISFSSDSSMVCVSSDKGTVHVF 266
                 57899965775226*************99999****997 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0036        11      45      82 ..     103     139 ..      64     156 .. 0.85
   2 !   15.3   0.0   6.2e-06     0.018      25      81 ..     183     238 ..     170     245 .. 0.80
   3 !    5.9   0.0    0.0051        15      38      69 ..     239     270 ..     233     274 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0036
  ANAPC4_WD40  45 aWkpdgklLavaysdgevrlldaesgkvvhslsvksek 82 
                  + k + + L+v+ +d +++++d++s k+++++++k++ 
   EFC39299.1 103 NVKVSKRRLVVVLQD-KIHIFDISSMKILRTIETKNNL 139
                  556677888888877.8***************999875 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 6.2e-06
  ANAPC4_WD40  25 ngqrvwtleedkedsevrsLaWkpdgklLavaysdge.vrlldaesgkvvhslsvkse 81 
                  n ++v  +  ++++s v+ +++++dg++La a  +g+ +r++++   +++h+l+ +s+
   EFC39299.1 183 NPKQVNFI--KAHKSDVSIIQFNQDGTMLATASGKGTvIRIFSIPGCELLHTLRRGST 238
                  56666666..789999********************6379***********9987766 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0051
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrlldaes 69 
                    ++ s++++ d ++ +v+ ++g+v++++ ++
   EFC39299.1 239 AARIYSISFSSDSSMVCVSSDKGTVHVFKLNQ 270
                  56789999999999*****9999999998766 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.21   6.4e+02      50      89 ..     101     138 ..      93     149 .. 0.63
   2 !    8.3   0.1   0.00033      0.97     185     215 ..     192     223 ..     179     228 .. 0.76
   3 !    7.7   0.1    0.0005       1.5     188     222 ..     240     274 ..     228     276 .] 0.85

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.21
    Ge1_WD40  50 vvnketeeraLlkglkgevldlafahvsskillavdekgs 89 
                 ++n+++++r L+  l+++++   f  +s kil +++ k +
  EFC39299.1 101 ILNVKVSKRRLVVVLQDKIH--IFDISSMKILRTIETKNN 138
                 55666666666666666665..344455555555555555 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00033
    Ge1_WD40 185 eehsliveaafspdGtalatasedGev.kffq 215
                  ++s ++   f  dGt latas  G+v + f 
  EFC39299.1 192 AHKSDVSIIQFNQDGTMLATASGKGTViRIFS 223
                 3446899999************9997526665 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0005
    Ge1_WD40 188 sliveaafspdGtalatasedGevkffqvyledee 222
                 + i + +fs+d   + ++s  G+v+ f++++++e+
  EFC39299.1 240 ARIYSISFSSDSSMVCVSSDKGTVHVFKLNQNQEK 274
                 4789999*********************9988665 PP

>> CNH  CNH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.0   0.00023      0.68     222     267 ..      92     137 ..      80     145 .. 0.86
   2 ?    3.1   0.0      0.02        59     129     158 ..     210     261 ..     173     275 .. 0.62

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00023
         CNH 222 dseleWegkPesvaclepyllafhknfieirsvetgelvqeisgkk 267
                  +el++ +++ +v +++  l+++ ++ i i+++++++++++i  k+
  EFC39299.1  92 ICELNFTSTILNVKVSKRRLVVVLQDKIHIFDISSMKILRTIETKN 137
                 6899999999999999999999999999999999999999998776 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.02
         CNH 129 k....................kklrefqvpaevfsisvl..kpklcvgvakg 158
                                      + lr  ++ a ++sis+   ++++cv++ kg
  EFC39299.1 210 AtasgkgtvirifsipgcellHTLRRGSTAARIYSISFSsdSSMVCVSSDKG 261
                 2444445333333333333334555556669999999999999999998665 PP

>> BBS2_N  Ciliary BBSome complex subunit 2, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.1      0.14   4.3e+02      52      52 ..      63      63 ..      16     128 .. 0.53
   2 ?    8.4   0.0   0.00066         2      15      61 ..     170     213 ..     158     222 .. 0.81
   3 ?   -2.0   0.0       1.1   3.4e+03      12      28 ..     254     270 ..     240     275 .. 0.48

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.14
      BBS2_N 52 k 52
                +
  EFC39299.1 63 S 63
                0 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00066
      BBS2_N  15 attagkvlihnphekeqklkserlsasesevslLninkevtalaagk 61 
                  t++g v+++++ + +   + + ++a++s+vs++++n++ t la+++
  EFC39299.1 170 PTESGDVILYDAINPK---QVNFIKAHKSDVSIIQFNQDGTMLATAS 213
                 59999*****987775...44456788****************9987 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1.1
      BBS2_N  12 laaattagkvlihnphe 28 
                 + +++  g v +++ ++
  EFC39299.1 254 VCVSSDKGTVHVFKLNQ 270
                 33333334444444332 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.2    0.0081        24     112     160 ..      89     137 ..      80     147 .. 0.85
   2 ?   -1.2   0.0      0.34     1e+03      72     103 ..     183     215 ..     170     224 .. 0.58
   3 ?    7.6   0.1   0.00072       2.2       2      34 ..     241     273 ..     240     275 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0081
   WD40_like 112 qleevllgqsseIkeikiennkiysLsesafivfdlfsqnieykisvkd 160
                 +  +  l+ +s I+++k+++ ++    +++  +fd+ s +i++ i+ k+
  EFC39299.1  89 NKAICELNFTSTILNVKVSKRRLVVVLQDKIHIFDISSMKILRTIETKN 137
                 4556668999*******************************99999887 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.34
   WD40_like  72 neeeve.nekieedistvkviddklliGtnkGs 103
                 n ++v+ ++  + d+s+++  +d  ++ t  G+
  EFC39299.1 183 NPKQVNfIKAHKSDVSIIQFNQDGTMLATASGK 215
                 444444133456677777777777666666654 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.00072
   WD40_like   2 eiYsidiskkgslilyGgkddkctvlklesles 34 
                  iYsi +s ++s++ + +++ ++ v+kl+++++
  EFC39299.1 241 RIYSISFSSDSSMVCVSSDKGTVHVFKLNQNQE 273
                 59**************************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       436  (0.0243181); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.54u 0.33s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 1654.87
//
Query:       EFC39300.1  [L=530]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (530 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2792  (0.155725); expected 358.6 (0.02)
Passed bias filter:                      653  (0.0364214); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.83u 0.35s 00:00:01.18 Elapsed: 00:00:00.55
# Mc/sec: 2919.94
//
Query:       EFC39301.1  [L=549]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0076   16.3   5.8      0.019   15.0   5.8    1.6  1  Pinin_SDK_memA  pinin/SDK/memA/ protein conserved region
  ------ inclusion threshold ------
      0.016   15.6   0.3       0.29   11.5   0.3    2.5  2  Gp-FAR-1        Nematode fatty acid retinoid binding protein 


Domain annotation for each model (and alignments):
>> Pinin_SDK_memA  pinin/SDK/memA/ protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   5.8   2.1e-06     0.019      16     112 ..     383     471 ..     377     479 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 2.1e-06
  Pinin_SDK_memA  16 gtLqkfkkeeekqkekeerraeiekrleekakeekeeleerkrekreeleeerraeqkelraleeklelkelmetwhenkkalanflrTkte..P 108
                       +q+fk+++++  + eerr+ i   + e + + ke++    +   ++l     + q ++    e l+++ +m+++ e+++ + nf++ + +  P
      EFC39301.1 383 TQMQQFKQADQELAAIEERRQMIVSNVVEMETQLKEQY----K---RALVSLHDISQLKM---SELLSRETEMRRRIEEMEWMNNFIQYQQTmtP 467
                     5789******9999999*********************....4...55666666666666...4445555588**************88765557 PP

  Pinin_SDK_memA 109 piyY 112
                     p+ +
      EFC39301.1 468 PLQF 471
                     7765 PP

>> Gp-FAR-1  Nematode fatty acid retinoid binding protein (Gp-FAR-1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0     0.062   5.5e+02      70      92 ..     227     249 ..     223     268 .. 0.77
   2 ?   11.5   0.3   3.2e-05      0.29      21      68 ..     373     420 ..     361     454 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.062
    Gp-FAR-1  70 kLspeakeFvkkliakgrkleaq 92 
                 +Lspe+++F + li  + + +a+
  EFC39301.1 227 NLSPETQQFSTSLIPPQEHSRAN 249
                 69***********9665555555 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 3.2e-05
    Gp-FAR-1  21 eekaqlkevvknykgyknedellaalKkkspaLyekaeklqaklkekv 68 
                 +e   l ev+++++++k  d+ laa+ ++   + +++ +++++lke+ 
  EFC39301.1 373 DETILLPEVFTQMQQFKQADQELAAIEERRQMIVSNVVEMETQLKEQY 420
                 55556789************************************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (549 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1021  (0.0569468); expected 358.6 (0.02)
Passed bias filter:                      393  (0.0219198); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.52
# Mc/sec: 3172.25
//
Query:       EFC39302.1  [L=191]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.024   14.8   3.1      0.036   14.2   3.1    1.2  1  DUF4870   Domain of unknown function (DUF4870)
        0.5   10.0   5.4       0.63    9.6   5.4    1.1  1  SUR7      SUR7/PalI family
       0.72    8.6   4.4        1.1    7.9   4.4    1.3  1  DUF2207   Predicted membrane protein (DUF2207)
        2.5    8.6   6.9        6.4    7.3   6.9    1.8  1  DUF2367   Uncharacterized conserved protein (DUF2367)
        4.9    7.0  16.2        1.7    8.5   2.4    2.0  2  DUF4013   Protein of unknown function (DUF4013)


Domain annotation for each model (and alignments):
>> DUF4870  Domain of unknown function (DUF4870)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   3.1     1e-05     0.036      42      96 ..     102     182 ..      91     189 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1e-05
     DUF4870  42 eqgkealNFqislliysiiliv...lsllvli.........................gf.lllllllllllnlvlviiaaikan 96 
                 +q+ eal F + +++++  l++   +s+   +                         gf + l l +l ++   ++iia+i+ +
  EFC39302.1 102 KQAEEALMFALLVTFVMWFLGIgfcFSC---FffvpvmkfrrssdprakqygqygqiGFfITLGLNILSVVVAAIIIIAIIASY 182
                 699***********99877777333333...2345999****************988773224444444444455555555443 PP

>> SUR7  SUR7/PalI family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   5.4   0.00018      0.63     111     178 ..     113     187 ..      77     190 .. 0.71

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00018
        SUR7 111 ltkalfilhiialvlsfislvvgllaicvspdnsr........llsflnlllsvlsflatllaalldtllfvfvrk 178
                 l+++++ ++ i++++s+  +v  ++ + +s d +         +++f++l l++ls++++++  + +++ ++ +  
  EFC39302.1 113 LVTFVMWFLGIGFCFSCFFFVP-VMKFRRSSDPRAkqygqygqIGFFITLGLNILSVVVAAIIIIAIIASYAAAAS 187
                 5566666666777777665444.3333222222223344444459999**9*******999999999999997665 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   4.4   0.00031       1.1     381     427 ..     105     181 ..      93     190 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.00031
     DUF2207 381 kklsalglgliilglilillallllvll..............................lvfllilllillliaiivl 427
                  +  +++l++++++++l+++++++++++                              l++l++++ ++++iaii+ 
  EFC39302.1 105 EEALMFALLVTFVMWFLGIGFCFSCFFFvpvmkfrrssdprakqygqygqigffitlgLNILSVVVAAIIIIAIIAS 181
                 444555555556666666666666655566699*****************999885554444444444444433332 PP

>> DUF2367  Uncharacterized conserved protein (DUF2367)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   6.9    0.0018       6.4       6      91 ..      36     128 ..       2     143 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0018
     DUF2367   6 ipsaavvakaPlplq.lpapkg.aevasasaqqqqqtta.tivvqP....aqsvvvvggCpaCrvgvLeddftclGilcaifffPlGilcCla 91 
                 +p+++ +  +P p+q + +p + + va  + q q+ t++  iv qP    +++  vv+g  a + g   ++     +l+  +++ lGi +C+ 
  EFC39302.1  36 QPTQPNAYGQPYPQQpYYDPSQqVPVAYGQPQPQYYTPQpVIVAQPtvatTTTTTVVNGVSAVGEGKQAEEALMFALLVTFVMWFLGIGFCFS 128
                 45555555555544312233332333333333333344314556776654567789***********99999999****************95 PP

>> DUF4013  Protein of unknown function (DUF4013)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   2.4   0.00046       1.7      61     117 ..      75     136 ..      70     146 .. 0.62
   2 ?    4.8   5.8    0.0064        23      81     120 ..     148     186 ..     141     190 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00046
     DUF4013  61 plii........alltllvalaslaagdsaagallvlallglllalllvllllllfglllpvala 117
                 p+i+        + +t++  ++++ +g++a  al++++l+++++ +l++ +++   ++++pv  +
  EFC39302.1  75 PVIVaqptvattTTTTVVNGVSAVGEGKQAEEALMFALLVTFVMWFLGIGFCFS-CFFFVPV--M 136
                 566666666664444455555666666677777777777788888887766666.4444444..4 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0064
     DUF4013  81 saagallvlallglllalllvllllllfglllpvalarfa 120
                 + ++ + ++++++l l +l+v+++++ + +++++++a+ a
  EFC39302.1 148 QYGQYGQIGFFITLGLNILSVVVAAI-IIIAIIASYAAAA 186
                 56677889999999999998888888.6666666655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1160  (0.0646996); expected 358.6 (0.02)
Passed bias filter:                      470  (0.0262145); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1090.86
//
Query:       EFC39303.1  [L=363]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.024   15.0   0.1        0.9    9.9   0.0    2.6  2  TetR_C_22   Tetracyclin repressor-like, C-terminal domain
      0.049   13.2   0.5      0.049   13.2   0.5    2.5  2  DUF3452     Domain of unknown function (DUF3452)
       0.56   10.3   7.6         25    5.0   0.7    4.4  4  Phg_2220_C  Conserved phage C-terminus (Phg_2220_C)
        3.5    7.8   5.6        8.4    6.6   5.6    1.8  1  EF-hand_2   EF hand


Domain annotation for each model (and alignments):
>> TetR_C_22  Tetracyclin repressor-like, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.2     0.053   2.4e+02      28      67 ..      14      53 ..       3      57 .. 0.83
   2 ?    9.9   0.0    0.0002       0.9       4      36 ..     163     195 ..     160     199 .. 0.88

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.053
   TetR_C_22 28 wlgdqadkalrdedadenralaarladalaplapdedaee 67
                +l+d + k  ++  ++e++++ ++l+++l++++ d+  e+
  EFC39303.1 14 HLADRIRKIQQASSQSEDQTNDKKLEQVLEQIFSDQEEEQ 53
                56777788888889999999*************9976665 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0002
   TetR_C_22   4 qdaldrlidryaemyreePafralwlgdqadka 36 
                 +d+  + i+r+ +++reeP f+ l  ++q   +
  EFC39303.1 163 EDLNSEGIERMKKLFREEPYFSLLSVATQHNSR 195
                 6888999********************997665 PP

>> DUF3452  Domain of unknown function (DUF3452)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   1.2     0.024   1.1e+02      43      87 ..      16      62 ..       6      80 .. 0.60
   2 ?   13.2   0.5   1.1e-05     0.049      44      88 ..     208     257 ..     202     276 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.024
     DUF3452 43 rqeieelernfsvttvif..kkYrqiFeelFlspadkeskrskknsa 87
                 ++i++++++ s +      kk +q+ e++F+++++++++ +k+ ++
  EFC39303.1 16 ADRIRKIQQASSQSEDQTndKKLEQVLEQIFSDQEEEQDQINKRIKK 62
                555666665555544333348999*********99444333333222 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 1.1e-05
     DUF3452  44 qeieelernfsvttvif.....kkYrqiFeelFlspadkeskrskknsaa 88 
                 ++++el ++f+++t i      k+Y+++++e +++p++k+sk+++k+ ++
  EFC39303.1 208 NRLRELSEHFQHSTQIPrsilvKNYQNAYDEYLNTPEKKKSKQEEKKAKM 257
                 5789999999999887666666***************7777777776665 PP

>> Phg_2220_C  Conserved phage C-terminus (Phg_2220_C)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.3     0.014        63       5      36 ..      38      68 ..      36      89 .. 0.88
   2 ?    0.1   0.0      0.19   8.5e+02      48      67 ..     125     144 ..     121     150 .. 0.82
   3 ?    1.1   0.0     0.095   4.3e+02       3      31 ..     152     180 ..     152     188 .. 0.89
   4 ?    5.0   0.7    0.0055        25       3      42 ..     238     277 ..     238     281 .. 0.91

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.014
  Phg_2220_C  5 LNekagkkfkaeskktkklIkarlkegytved 36
                L ++ ++ f  +++++++ I++r+k++y   d
  EFC39303.1 38 LEQVLEQIFS-DQEEEQDQINKRIKKKYIPYD 68
                7788889999.9999***********997666 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.19
  Phg_2220_C  48 WlndtkmekYLrPeTLFkge 67 
                 W n++++e  +  +T+Fk++
  EFC39303.1 125 WSNEEEFEGLICGHTIFKSD 144
                 99***************554 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.095
  Phg_2220_C   3 eyLNekagkkfkaeskktkklIkarlkeg 31 
                 +yL++ ++ k+++ +++ ++ +k++++e+
  EFC39303.1 152 KYLKKDSNGKYEDLNSEGIERMKKLFREE 180
                 59**********99999999999998875 PP

  == domain 4  score: 5.0 bits;  conditional E-value: 0.0055
  Phg_2220_C   3 eyLNekagkkfkaeskktkklIkarlkegytvedlkkVid 42 
                 eyLN+  +kk k+e+kk k  I++ ++++ +++ + ++ +
  EFC39303.1 238 EYLNTPEKKKSKQEEKKAKMTIEEFISSKMDIDTFDDMLQ 277
                 69****************************9999987765 PP

>> EF-hand_2  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   5.6    0.0019       8.4      34      84 ..       8      58 ..       5     268 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0019
   EF-hand_2 34 dsvsisivaevlkeiglssdefdrllsvsqledvLldlysalekkksslgq 84
                 + +++ +a+ +++i+  s++++   + ++le+vL++++s  e+++++ ++
  EFC39303.1  8 TLFNLKHLADRIRKIQQASSQSEDQTNDKKLEQVLEQIFSDQEEEQDQINK 58
                56788999999****************************997766655443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (363 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2323  (0.129567); expected 358.6 (0.02)
Passed bias filter:                      720  (0.0401584); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2167.95
//
Query:       EFC39304.1  [L=215]
Description: hypothetical protein NAEGRDRAFT_73011 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00049   20.2   0.1       0.12   12.5   0.0    2.3  2  SPRY      SPRY domain


Domain annotation for each model (and alignments):
>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.0   0.00082        15      33      76 ..      93     145 ..      54     162 .. 0.70
   2 !   12.5   0.0   6.8e-06      0.12      91     115 ..     190     214 ..     180     215 .] 0.89

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.00082
                 S...TSSTTEEEEETETTEEE......EETESCEEEESSSSTTSEEEEEEETT CS
        SPRY  33 e...gddrgswglcgdngtrt......saeqskaygkqparegdviGvalDle 76 
                     g++++s g+ + +gt+       s + +    +q++++gd+i + +Dl 
  EFC39304.1  93 GeviGWQSESKGIASITGTKEiihavlSDKHTCCKLEQNFETGDIIQIEFDLT 145
                 13448888887777766665555455433333333467999**********87 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 6.8e-06
                 EEEESTTTSSEEEEEEE.STCEEEE CS
        SPRY  91 vaFrnvrgaelfPvvslgngaslki 115
                 ++F +vr+a+++P+vs+++g++l +
  EFC39304.1 190 YPFGDVRFAPFVPAVSVSSGQTLSF 214
                 79*******************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (215 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       350  (0.0195214); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 1299.04
//
Query:       EFC39305.1  [L=1682]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.6e-91  301.2 190.7    1.1e-18   67.8  10.9   15.2 15  Big_9       Bacterial Ig domain
    3.8e-55  184.4 140.5    6.3e-10   39.5   2.5   14.6 13  Cadherin_4  Bacterial cadherin-like domain
    3.5e-17   62.2 108.0    3.6e-07   30.1   0.5   14.6 16  Cadherin_5  Cadherin-like domain
    8.8e-16   58.6   0.2    5.2e-15   56.1   0.1    2.5  2  VWA         von Willebrand factor type A domain
    1.7e-09   38.3   0.4    1.1e-08   35.7   0.2    2.5  2  VWA_2       von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> Big_9  Bacterial Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.8   0.6   5.1e-16   1.8e-12      13      88 ..      57     133 ..      45     135 .. 0.90
   2 !   40.3   5.7   1.1e-13     4e-10       1      88 [.     136     240 ..     136     242 .. 0.79
   3 !   44.4   5.1     6e-15   2.1e-11       5      88 ..     247     331 ..     243     333 .. 0.84
   4 !   15.6   7.9   5.6e-06      0.02       6      90 .]     339     444 ..     334     444 .. 0.76
   5 !   31.9   3.6   4.5e-11   1.6e-07       4      88 ..     448     539 ..     445     540 .. 0.77
   6 !   22.9   7.6   2.9e-08    0.0001       5      89 ..     556     646 ..     553     647 .. 0.81
   7 !   67.8  10.9     3e-22   1.1e-18       3      89 ..     653     740 ..     651     741 .. 0.87
   8 !    9.0   1.6   0.00065       2.3      53      87 ..     741     777 ..     740     780 .. 0.91
   9 !   30.2   5.3   1.6e-10   5.8e-07       4      88 ..     784     865 ..     781     867 .. 0.78
  10 !   11.4  13.0   0.00011      0.41       3      88 ..     871     988 ..     867     989 .. 0.73
  11 !   16.4   6.4   3.1e-06     0.011       3      87 ..     997    1085 ..     995    1087 .. 0.76
  12 !   15.2   8.2   7.8e-06     0.028       1      89 [.    1091    1176 ..    1091    1177 .. 0.87
  13 !   18.9   7.5   5.3e-07    0.0019       4      89 ..    1183    1274 ..    1180    1275 .. 0.80
  14 !   12.6   2.5     5e-05      0.18       3      84 ..    1282    1375 ..    1280    1391 .. 0.65
  15 ?   -4.0   0.1         5   1.8e+04      30      41 ..    1456    1467 ..    1435    1481 .. 0.44

  Alignments for each domain:
  == domain 1  score: 47.8 bits;  conditional E-value: 5.1e-16
       Big_9  13 daPvavddsvtvt.....edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                 + Pvav+d +++      + +vl+nd dp g +++++++    v  p++G+++i ++ ++ y  n  f+g+d+f+Y++++g
  EFC39305.1  57 QRPVAVNDLASTYkniplTINVLSNDYDPKGANISLVQF----VVYPNHGSASIQSNSQVLYKSNGTFAGNDTFSYQITNG 133
                 78**********966667777799**********98877....569*********************************98 PP

  == domain 2  score: 40.3 bits;  conditional E-value: 1.1e-13
       Big_9   1 tatvtvtvtpvndaPvavddsvtvt...edsv..........landtdpdgdaltvtsltvtlvta.....panGtvtinadgtltytpnagfsgtdsf 81 
                 ta+++vt++  n++P av+  vtv+   ++sv           +   dpd+ +l ++++++t +t      ++ G++++++ + + ytp+ gf+g ++f
  EFC39305.1 136 TANASVTIQVLNRPPEAVPIRVTVSknaKNSVinifdyvgdnDEKINDPDNGDL-IQAVSFTNQTIvsgnsAETGSISVDPANGFYYTPAYGFNGVEQF 233
                 78889999999*************955544447776665444335567777777.6666666554477788*********9999*************** PP

       Big_9  82 tYtvsDg 88 
                  Y++sDg
  EFC39305.1 234 AYSISDG 240
                 ******9 PP

  == domain 3  score: 44.4 bits;  conditional E-value: 6e-15
       Big_9   5 tvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpna..gfsgtdsftYtvsDg 88 
                  +tvt  nd+P+avdd++ +++  +     land d++gd+ ++     t++ ++++G + + +  ++ty  +   +   +dsf+Yt+sDg
  EFC39305.1 247 IITVTVSNDPPIAVDDTYRIPKFRSlvldvLANDYDINGDDFNI-----TSALGTGYGAINVGE-KKITYITSGsvNTKYSDSFEYTISDG 331
                 5788888**********9999555555565***********865.....5567899****9995.5*****9998899999*********9 PP

  == domain 4  score: 15.6 bits;  conditional E-value: 5.6e-06
       Big_9   6 vtvtpvndaPvavddsvtvtedsv....landtdpdgdaltvtsltvtlvta...................panGtvtinadgtltytpnagfsgtdsf 81 
                 v ++  n++Pv+ + +vtv++ s+    +    d+dg +l  +  t+t + a                    +  +v+ n + t+ +tp +++  t +f
  EFC39305.1 339 VVISVYNQNPVVYSKTVTVAKSSTnnsiTIDYYDADGKDLI-VPSTITPSLAsvssslqkttnyvniffdcCDWLSVETN-NYTILFTPVSNQVYTQTF 435
                 566667*************955555555558889***9994.44455444447888888888888888855445555555.668*************** PP

       Big_9  82 tYtvsDgsg 90 
                 t+  sDg+g
  EFC39305.1 436 TVVMSDGEG 444
                 *******97 PP

  == domain 5  score: 31.9 bits;  conditional E-value: 4.5e-11
       Big_9   4 vtvtvtpvndaPvavddsvtvt.edsv....landtdpdgdaltvtsltvtlvta......panGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                   +t++ vn++Pvavdd ++ +   +v    +and d++  +    ++++++          ++G++t+ +     y++++gf gtd  +Y +sD 
  EFC39305.1 448 GIITINVVNTPPVAVDDLAECNkNLQVyvnlVANDYDINSGDTA--KIVLSS--VgwnsttLNGGSLTLFNETHALYSAPNGFLGTDVAQYVISDQ 539
                 5699**************999852333666699****9865542..222322..122344599*******9999*********************7 PP

  == domain 6  score: 22.9 bits;  conditional E-value: 2.9e-08
       Big_9   5 tvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgt..ltytpnagfsgtdsftYtvsDgs 89 
                 ++tvt +n +P+ +dd+++++++ +     l+nd+dp++   +v  ++++++++ +n ++ti +  +  l+y  ++++  td +tY v+  +
  EFC39305.1 556 KLTVTVINNPPTPADDTFEISKGVTsilnvLDNDSDPNDGLGSVFIVNFVSASTIKNIQATIVPGTKntLSYA-ASNAEYTDYLTYDVTHQD 646
                 4678888**********9998665566677***********999999999****9999999994433326665.458899******999665 PP

  == domain 7  score: 67.8 bits;  conditional E-value: 3e-22
       Big_9   3 tvtvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDgs 89 
                  +tvt + vndaPvavdds+++  + +      +nd+d +gd  t    tv ++t+p++G+v++ ++  ++ytp++gf gtdsftY+ +Dg+
  EFC39305.1 653 RATVTLQVVNDAPVAVDDSYSTLWNRSvdcsvKDNDSDKNGDLTT---STVHITTNPTHGSVVVLGS-VVRYTPTDGFVGTDSFTYKLNDGT 740
                 578888889*************966663555567*******9765...48999************87.9*********************97 PP

  == domain 8  score: 9.0 bits;  conditional E-value: 0.00065
       Big_9  53 apanGtvtinadgtltytpna..gfsgtdsftYtvsD 87 
                  ++ Gtvt++++ t+ + pn+     g+ sftY + D
  EFC39305.1 741 DSSVGTVTLSDSKTIKFIPNTvsATVGSKSFTYYAYD 777
                 5789*****************9999********8877 PP

  == domain 9  score: 30.2 bits;  conditional E-value: 1.6e-10
       Big_9   4 vtvtvtpvndaPvavddsvtvtedsv......landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                  tv+v+ +n++Pv +  s+t++   +      l+nd dp+gd++++      +v++++  +v+ +   ++ yt+ ++    d+f+Y ++D+
  EFC39305.1 784 GTVNVQVTNTKPVGTGESYTLHWAAPatlfsvLDNDMDPNGDPISL-----YSVSGSTAASVSGS---SVKYTAKKN-GLADTFQYVITDT 865
                 57888888**********99984444444666***********974.....34566665555555...9*****999.8999********6 PP

  == domain 10  score: 11.4 bits;  conditional E-value: 0.00011
       Big_9   3 tvtvtvtp.vndaPvavdds................vtvtedsv.............landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytp 71 
                 t+tv+v    nd P a++ +                +      +             l++    d d+l  + +   ++++  +G+v+++ +  ++ytp
  EFC39305.1 871 TITVNVGFtNNDVPSASNVAtsvhwrtllsqslnqdF------TtattkwkssvsvdLSSGACTDSDSLDTAYF-NGATSSVVGGSVSVS-NKIVSYTP 961
                 4455554489********9944444444444444332......0333344555677888888888889886554.566778999*****9.78****** PP

       Big_9  72 na..........gfsgtdsftYtvsDg 88 
                 +a           +s t sf+++ +Dg
  EFC39305.1 962 SAtsltftgsngAYSATGSFKFQCTDG 988
                 ***********99*************8 PP

  == domain 11  score: 16.4 bits;  conditional E-value: 3.1e-06
       Big_9    3 tvtvtvtpvndaPvavddsvtvtedsv..........landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsD 87  
                  tvtvtvt  n aP+ +  s++++ d +          +a+ +d+dgd++++t++    v++ +  tv+  ++g    t n+   g  +++++  D
  EFC39305.1  997 TVTVTVT--NNAPTGTGKSTSIDRDYTtstydftwaqIATVSDADGDSISYTNF----VSSDSSITVSNIGTGIRLTTSNKLILGLKTIQFRLFD 1085
                  6666666..**********88875555556777999999***********9988....6778888888888887777777666666666666655 PP

  == domain 12  score: 15.2 bits;  conditional E-value: 7.8e-06
       Big_9    1 tatvtvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDgs 89  
                  t+++t+ vt  n aP+ ++ s+ + + ++     l ++td ++d++t    t+t + +++ Gt+t +     ++ +++  sgt ++tYt +D++
  EFC39305.1 1091 TSNLTFSVTFLNSAPICSSSSIDLLKKGSidlatLFSATDSNNDPIT---NTITNSISSTFGTLTGT-----VFKASSTNSGTFQVTYTSTDSQ 1176
                  56789999999**********999866665866666*********98...4688889999****998.....89******************86 PP

  == domain 13  score: 18.9 bits;  conditional E-value: 5.3e-07
       Big_9    4 vtvtvtpvndaPvavddsvtvt...edsvla...ndtdpdgdaltvtsltvtlvta...panGtvtinadgtltytpna.gfsgtdsftYtvsDgs 89  
                   +vtv+  n+ Pva+d ++tv    + +v +   ++td+dg++     lt++++     +   ++ti+++g +t+t  +   +gt + +++vsD++
  EFC39305.1 1183 CSVTVNIYNQIPVANDVTFTVVplaTSNVHTfgyTATDADGSDV----LTFSQTGHscgSIVSSLTISTSGVVTFTRLPtVITGTCTMNVKVSDNN 1274
                  57999999**********99976656666335568999999887....5565444455688899************8885789***********85 PP

  == domain 14  score: 12.6 bits;  conditional E-value: 5e-05
       Big_9    3 tvtvtvtpvndaPvavddsvtvtedsv........landtdpdgdaltvtsltvtlvta...............panGtvtinadgtltytpnagfs 76  
                  t+ +t       P+a+dd ++++++++        l+nd+d  g++ t++  +++                            +   +  + ++   
  EFC39305.1 1282 TAVITFVLSPSTPTANDDRFEINQGQTiriyvwqiLQNDIDEFGSNTTLKLTSIS---CpnsnychktprlvtvN--------GVAAIEVDSDTTTC 1367
                  455555556789******************************9999886533333...23468999666666542........33334444444444 PP

       Big_9   77 gtdsftYt 84  
                    d f+Yt
  EFC39305.1 1368 QADKFQYT 1375
                  44444443 PP

  == domain 15  score: -4.0 bits;  conditional E-value: 5
       Big_9   30 landtdpdgdal 41  
                  l+nd    +++l
  EFC39305.1 1456 LSNDGTTINNTL 1467
                  223332222322 PP

>> Cadherin_4  Bacterial cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.3   0.3   1.6e-11   5.6e-08      12      71 ..      57     113 ..      51     128 .. 0.90
   2 !   11.5   4.0    0.0001      0.36       1      71 [.     137     220 ..     137     221 .. 0.65
   3 !   39.5   2.5   1.8e-13   6.3e-10       5      71 ..     248     325 ..     245     326 .. 0.75
   4 !    5.2   1.6    0.0093        33       7      57 ..     341     386 ..     337     401 .. 0.76
   5 !   29.3   2.1   2.8e-10     1e-06       5      65 ..     450     513 ..     448     520 .. 0.78
   6 !   21.1   3.8     1e-07   0.00036       5      54 ..     557     603 ..     554     635 .. 0.74
   7 !   30.4  11.8   1.2e-10   4.5e-07       3      65 ..     654     714 ..     653     757 .. 0.91
   8 !   26.9   1.2   1.6e-09   5.7e-06       3      58 ..     784     837 ..     782     860 .. 0.85
   9 ?    1.3   5.4      0.15   5.5e+02       2      49 ..     871     955 ..     870     983 .. 0.44
  10 !   14.8   8.5     9e-06     0.032       4      59 ..     997    1052 ..     995    1064 .. 0.76
  11 !    9.6   2.7   0.00039       1.4       2      63 ..    1093    1152 ..    1092    1171 .. 0.88
  12 !   15.9   5.4   4.2e-06     0.015       4      72 .]    1184    1253 ..    1181    1267 .. 0.80
  13 !   13.8   1.0   1.9e-05      0.07       2      55 ..    1282    1337 ..    1281    1390 .. 0.78

  Alignments for each domain:
  == domain 1  score: 33.3 bits;  conditional E-value: 1.6e-11
  Cadherin_4  12 daPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlnadGsft 71 
                 ++Pvav+d a++  + plti   nvl+nd+D+ g  ++ +++ v +++G+ +++++ ++ 
  EFC39305.1  57 QRPVAVNDLASTYKNIPLTI---NVLSNDYDPKGANISLVQFVVYPNHGSASIQSNSQVL 113
                 58******************...**************************98888775554 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.0001
  Cadherin_4   1 atvtitvtgvndaPvavddsatvtedtpltitagnvl....and...tDvdgdd.ltvtavt.......vagtyGtltlnadGsft 71 
                 a++++t++  n +P av+  +tv  ++  ++   n+     +nd   +D+d++d ++++++t        +++ G++++++   f 
  EFC39305.1 137 ANASVTIQVLNRPPEAVPIRVTVSKNAKNSVI--NIFdyvgDNDekiNDPDNGDlIQAVSFTnqtivsgNSAETGSISVDPANGFY 220
                 6789*******************997665542..333333455533389**99955555555222222114578999999955554 PP

  == domain 3  score: 39.5 bits;  conditional E-value: 1.8e-13
  Cadherin_4   5 itvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvag..............tyGtltlnadGsft 71 
                 itvt  nd+P+avdd++ ++   +l+    +vland+D++gdd+ +t++ ++g              t G+++   ++sf+
  EFC39305.1 248 ITVTVSNDPPIAVDDTYRIPKFRSLVL---DVLANDYDINGDDFNITSALGTGygainvgekkityiTSGSVNTKYSDSFE 325
                 9**************************...9*****************986663333333333322333556655555555 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.0093
  Cadherin_4   7 vtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvag 57 
                 +   n++Pv+   ++tv+  ++ +     ++ + +D+dg dl v ++ +++
  EFC39305.1 341 ISVYNQNPVVYSKTVTVAKSSTNNS----ITIDYYDADGKDLIVPST-ITP 386
                 55569************99666555....566899******988665.344 PP

  == domain 5  score: 29.3 bits;  conditional E-value: 2.8e-10
  Cadherin_4   5 itvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd.....ltvtavt.vagtyGtltln 65 
                 it++ vn +Pvavdd a+++ + ++ +   n+ and+D++++d     l+ ++ + ++ ++G+ltl 
  EFC39305.1 450 ITINVVNTPPVAVDDLAECNKNLQVYV---NLVANDYDINSGDtakivLSSVGWNsTTLNGGSLTLF 513
                 9**************************...9*********666455333333333234477899975 PP

  == domain 6  score: 21.1 bits;  conditional E-value: 1e-07
  Cadherin_4   5 itvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavt 54 
                 +tvt  n++P+ +dd++++  + +      nvl+nd+D++++  +v +v+
  EFC39305.1 557 LTVTVINNPPTPADDTFEISKGVTSIL---NVLDNDSDPNDGLGSVFIVN 603
                 79999*****************99999...9********98775555554 PP

  == domain 7  score: 30.4 bits;  conditional E-value: 1.2e-10
  Cadherin_4   3 vtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd.ltvtavtvagtyGtltln 65 
                 +t+t + vndaPvavdds+++  + ++     +v +nd+D +gd  ++ + +t+++t+G++++ 
  EFC39305.1 654 ATVTLQVVNDAPVAVDDSYSTLWNRSVDC---SVKDNDSDKNGDLtTSTVHITTNPTHGSVVVL 714
                 58999999*********************...8*********999777888999****998874 PP

  == domain 8  score: 26.9 bits;  conditional E-value: 1.6e-09
  Cadherin_4   3 vtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagt 58 
                  t++v+ +n  Pv + +s+t    +p+t    +vl+nd D++gd+++  +v+++++
  EFC39305.1 784 GTVNVQVTNTKPVGTGESYTLHWAAPATL--FSVLDNDMDPNGDPISLYSVSGSTA 837
                 599*************************9..5**************9999986443 PP

  == domain 9  score: 1.3 bits;  conditional E-value: 0.15
  Cadherin_4   2 tvtitvtgv.ndaPvavddsatv...................tedtpltitagnvl.andtDvdgddl...................t 49 
                 t+t++v  + nd P a++ + +v                      +++++   ++  +  tD d+ d+                    
  EFC39305.1 871 TITVNVGFTnNDVPSASNVATSVhwrtllsqslnqdfttattKWKSSVSV---DLSsGACTDSDSLDTayfngatssvvggsvsvsnK 955
                 6666666443899*****98888555555444432222111111222223...22234445555444223333333333333333330 PP

  == domain 10  score: 14.8 bits;  conditional E-value: 9e-06
  Cadherin_4    4 titvtgvndaPvavddsatvtedtpltita..gnvlandtDvdgddltvtavtvagty 59  
                  t+tvt +n+aP+ +  s +++ d ++++ +     +a+ +D+dgd++++t +    + 
  EFC39305.1  997 TVTVTVTNNAPTGTGKSTSIDRDYTTSTYDftWAQIATVSDADGDSISYTNFV--SSD 1052
                  8899999***************966664333355569************9985..333 PP

  == domain 11  score: 9.6 bits;  conditional E-value: 0.00039
  Cadherin_4    2 tvtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavt.vagtyGtlt 63  
                  ++t++vt  n aP+ +  s+     +++       l  +tD ++d++t t+++ ++ t Gtlt
  EFC39305.1 1093 NLTFSVTFLNSAPICSSSSIDLLKKGSIDL---ATLFSATDSNNDPITNTITNsISSTFGTLT 1152
                  689***************************...78899********88887762588889887 PP

  == domain 12  score: 15.9 bits;  conditional E-value: 4.2e-06
  Cadherin_4    4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd.ltvtavt..vagtyGtltlnadGsftY 72  
                  ++tv+  n+ Pva+d ++tv   ++ ++   +   ++tD+dg d lt++++         +lt++ +G +t+
  EFC39305.1 1184 SVTVNIYNQIPVANDVTFTVVPLATSNVH--TFGYTATDADGSDvLTFSQTGhsCGSIVSSLTISTSGVVTF 1253
                  89********************9999996..45567999998888999988622122234677777777765 PP

  == domain 13  score: 13.8 bits;  conditional E-value: 1.9e-05
  Cadherin_4    2 tvtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd..ltvtavtv 55  
                  t+ it       P+a+dd +++++++++ i   ++l nd D  g    l  t+++ 
  EFC39305.1 1282 TAVITFVLSPSTPTANDDRFEINQGQTIRIYVWQILQNDIDEFGSNttLKLTSISC 1337
                  566777777789******************99*********765552377777763 PP

>> Cadherin_5  Cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.5     1e-10   3.6e-07       3      97 ..      57     145 ..      55     146 .. 0.91
   2 !   20.5   1.1   9.8e-08   0.00035      35      96 ..     183     251 ..     179     254 .. 0.72
   3 !   14.8   1.7   5.8e-06     0.021      28      88 ..     275     335 ..     253     343 .. 0.74
   4 ?   -0.2   0.1      0.27   9.8e+02       2      44 ..     345     381 ..     344     401 .. 0.76
   5 ?    2.2   0.2     0.048   1.7e+02      57      87 ..     415     445 ..     412     454 .. 0.84
   6 !    9.0   2.0   0.00038       1.4       1      85 [.     455     540 ..     455     550 .. 0.81
   7 ?    3.5   2.1     0.019        70      28      97 ..     584     658 ..     562     660 .. 0.65
   8 !   16.2   5.5   2.1e-06    0.0074      31      93 ..     686     747 ..     661     751 .. 0.68
   9 ?    1.3   1.0     0.093   3.3e+02      50      98 .]     742     791 ..     740     791 .. 0.83
  10 !   10.3   1.7   0.00015      0.54      28      95 ..     814     876 ..     791     879 .. 0.71
  11 ?    0.3   0.1      0.19   6.9e+02      69      97 ..     973    1002 ..     944    1003 .. 0.65
  12 !   11.2   1.7   7.5e-05      0.27       2      96 ..    1004    1097 ..    1003    1100 .. 0.76
  13 !    5.0   1.3    0.0067        24      30      97 ..    1125    1187 ..    1101    1189 .. 0.68
  14 ?    3.2   1.6     0.025        89      33      87 ..    1218    1276 ..    1197    1286 .. 0.78
  15 ?   -1.7   0.0      0.84     3e+03      14      48 ..    1301    1337 ..    1292    1380 .. 0.77
  16 ?   -1.6   0.0      0.75   2.7e+03      56      81 ..    1600    1625 ..    1589    1635 .. 0.85

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 1e-10
  Cadherin_5   3 daPvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasltv 97 
                 ++Pv+ +  +la++ ++ +lti+   +L+n+ D+ g ++s ++  +  ++G+   +++ ++ ++ +  + G+ t+sY+++ g  +t++a+++++v
  EFC39305.1  57 QRPVAVN--DLASTYKNIPLTIN---VLSNDYDPKGANISLVQFVVYPNHGSASIQSNSQVLYKSNGTFAGNDTFSYQITNGY-KTANASVTIQV 145
                 5688886..5899999******9...*****************999999*********************************7.78888888776 PP

  == domain 2  score: 20.5 bits;  conditional E-value: 9.8e-08
  Cadherin_5  35 Dvd.gdtLsvsslta.......daenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttataslt 96 
                 D+d gd ++ +s t        +ae+G++  +    f +tp+  +nG  ++ Y++sDg   t+++ +++t
  EFC39305.1 183 DPDnGDLIQAVSFTNqtivsgnSAETGSISVDPANGFYYTPAYGFNGVEQFAYSISDGY-DTSSSIITVT 251
                 66655555555554444555657778***9999999**********************7.4444555554 PP

  == domain 3  score: 14.8 bits;  conditional E-value: 5.8e-06
  Cadherin_5  28 qLLanasDvdgdtLsvssltadaenGtvv.dngdGtftftpeanynGevtlsYtvsDgeggt 88 
                 ++Lan+ D++gd+ +++s    ++ G +   ++  t+      n + + +++Yt+sDg +++
  EFC39305.1 275 DVLANDYDINGDDFNITSAL-GTGYGAINvGEKKITYITSGSVNTKYSDSFEYTISDGVATS 335
                 59****************95.5557777514455566666677777778*********7554 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.27
  Cadherin_5   2 ndaPvvsse.vtlaagseDtaltitaaqLLanasDvdgdtLsvs 44 
                 n++Pvv s+ vt+a+ s ++++ti+       + D+dg++L v 
  EFC39305.1 345 NQNPVVYSKtVTVAKSSTNNSITID-------YYDADGKDLIVP 381
                 8889887666999999999999998.......667776666665 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.048
  Cadherin_5  57 dngdGtftftpeanynGevtlsYtvsDgegg 87 
                 + ++ t+ ftp +n   + t++   sDgeg+
  EFC39305.1 415 ETNNYTILFTPVSNQVYTQTFTVVMSDGEGT 445
                 567889**********************965 PP

  == domain 6  score: 9.0 bits;  conditional E-value: 0.00038
  Cadherin_5   1 vndaPvvssevtlaagseDtaltitaaqLLanasDvd.gdt..Lsvssl...tadaenGtvvdngdGtftftpeanynGevtlsYtvsDge 85 
                 vn  Pv+ +  +la+ +++ ++ ++   L+an+ D++ gdt  +  ss+   +++ + G+++  ++    +   + + G+   +Y +sD +
  EFC39305.1 455 VNTPPVAVD--DLAECNKNLQVYVN---LVANDYDINsGDTakIVLSSVgwnSTTLNGGSLTLFNETHALYSAPNGFLGTDVAQYVISDQS 540
                 688899886..58899999999999...*********9999664445553233355679999999999999******************85 PP

  == domain 7  score: 3.5 bits;  conditional E-value: 0.019
  Cadherin_5  28 qLLanasDvd.g.dtLsvssl.ta...daenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasltv 97 
                 ++L n+sD++ g  ++ +++  +a   ++ ++t+v     t ++  ++n + +  l+Y+v+   g t+t  a++t+
  EFC39305.1 584 NVLDNDSDPNdGlGSVFIVNFvSAstiKNIQATIVPGTKNTLSYA-ASNAEYTDYLTYDVTHQDGLTSTYRATVTL 658
                 48888888874222333333213333378899***9999999996.456666788999998777777766666665 PP

  == domain 8  score: 16.2 bits;  conditional E-value: 2.1e-06
  Cadherin_5  31 anasDvdgdt.LsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttata 93 
                  n+sD +gd   s + +t++ ++G+vv  g   + +tp+  + G+ +++Y+ +Dg+ ++   t+
  EFC39305.1 686 DNDSDKNGDLtTSTVHITTNPTHGSVVVLG-SVVRYTPTDGFVGTDSFTYKLNDGTDSS-VGTV 747
                 5777877775355566677899*****955.5799********************8544.4554 PP

  == domain 9  score: 1.3 bits;  conditional E-value: 0.093
  Cadherin_5  50 aenGtvvdngdGtftftpeanyn..GevtlsYtvsDgeggtttatasltva 98 
                 ++ Gtv+     t+ f p++     G+ +++Y   D + + t+ t++++v+
  EFC39305.1 742 SSVGTVTLSDSKTIKFIPNTVSAtvGSKSFTYYAYDYN-KKTQGTVNVQVT 791
                 55799999999999**99975544599**********8.888899999885 PP

  == domain 10  score: 10.3 bits;  conditional E-value: 0.00015
  Cadherin_5  28 qLLanasDvdgdtLsvssltadaenGtvvdngdG.tftftpeanynGevtlsYtvsDgeggtttatasl 95 
                 ++L n+ D++gd +s  s++     G++++   G ++ +t ++n   + t++Y ++D+ +++ t t+++
  EFC39305.1 814 SVLDNDMDPNGDPISLYSVS-----GSTAASVSGsSVKYTAKKNGL-ADTFQYVITDTVSQSDTITVNV 876
                 59*****************4.....666666666367777777644.459********98888877765 PP

  == domain 11  score: 0.3 bits;  conditional E-value: 0.19
  Cadherin_5   69 anynGevtlsYtvsDge.ggtttatasltv 97  
                    y+ + +++++ +Dg  ++  + t+++tv
  EFC39305.1  973 GAYSATGSFKFQCTDGMlTANNPGTVTVTV 1002
                  456667777777777741234445555554 PP

  == domain 12  score: 11.2 bits;  conditional E-value: 7.5e-05
  Cadherin_5    2 ndaPvvssevtlaagseDt.altitaaqLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttataslt 96  
                  n+aP+ +++ t  + +  t ++ +t aq +a +sD+dgd++s ++   ++++ tv + g G    t ++   G  t++++  Dg    +t++++++
  EFC39305.1 1004 NNAPTGTGKSTSIDRDYTTsTYDFTWAQ-IATVSDADGDSISYTNFVSSDSSITVSNIGTGIRLTTSNKLILGLKTIQFRLFDGL-HYSTSNLTFS 1097
                  8999999884443443333366677666.799*************988887888889999999999999999************5.3444444444 PP

  == domain 13  score: 5.0 bits;  conditional E-value: 0.0067
  Cadherin_5   30 LanasDvdgdtLs..vssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasltv 97  
                  L  a+D ++d ++  +++ +++++ Gt++    Gt +f+  +  +G+ +++Yt +D +++ +++  s+tv
  EFC39305.1 1125 LFSATDSNNDPITntITN-SISSTFGTLT----GT-VFKASSTNSGTFQVTYTSTDSQAT-SSSACSVTV 1187
                  456889999886511444.3566677777....55.588888889************955.445555555 PP

  == domain 14  score: 3.2 bits;  conditional E-value: 0.025
  Cadherin_5   33 asDvd.gdtLsvssltadaenGtvv....dngdGtftftpe.anynGevtlsYtvsDgegg 87  
                  a+D+d +d L+ s+    ++ G++v        G +tft   +  +G+ t++ +vsD++  
  EFC39305.1 1218 ATDADgSDVLTFSQT--GHSCGSIVssltISTSGVVTFTRLpTVITGTCTMNVKVSDNNLP 1276
                  799995577999988..4445666644447899*999997526679***********9844 PP

  == domain 15  score: -1.7 bits;  conditional E-value: 0.84
  Cadherin_5   14 aagseDtaltitaaqLLanasDvd..gdtLsvsslta 48  
                   ++++++++ i   q+L+n+ D    + tL+ +s++ 
  EFC39305.1 1301 FEINQGQTIRIYVWQILQNDIDEFgsNTTLKLTSISC 1337
                  4678888999999999999999763245588888765 PP

  == domain 16  score: -1.6 bits;  conditional E-value: 0.75
  Cadherin_5   56 vdngdGtftftpeanynGevtlsYtv 81  
                   +n+ G + ++ ++ ynG+ ++++++
  EFC39305.1 1600 KRNASGVVPYDLDNPYNGNNKVQWKI 1625
                  578999999**********9999987 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.4   5.1e+03      29      45 ..      77      95 ..      63     126 .. 0.76
   2 !   56.1   0.1   1.4e-18   5.2e-15       1     117 [.    1402    1514 ..    1402    1565 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.4
                HHHT..BTTTTEEEEEEEE CS
         VWA 29 ekle..vgpegtrvglvqf 45
                + l+  ++p+g++++lvqf
  EFC39305.1 77 NVLSndYDPKGANISLVQF 95
                444433599********99 PP

  == domain 2  score: 56.1 bits;  conditional E-value: 1.4e-18
                  EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHG CS
         VWA    1 DivfvlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssa 97  
                  D vf+lD+Sgs+g  n +++++  k++ ++++++++++ v++v f s+++   +l+++   +++++ l n+ y+ ++t  t  +l  a++ +++ ++
  EFC39305.1 1402 DFVFLLDASGSIGTTNYNSMRTLCKQITGRMSISSDSILVSIVRFHSNATLALKLSNDG--TTINNTLTNMAYEASSTG-TIPGLRVAVD-ALRPAN 1494
                  679******************************************************88..9*****************.999******9.777777 PP

                  TSSTTSEEEEEEEESS--CS CS
         VWA   98 gaRenakkviilltdGksnd 117 
                  g R++a kvi +ltdG  n 
  EFC39305.1 1495 GGRDDADKVIFILTDGVANV 1514
                  77**************9876 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.88   3.2e+03      30      59 ..    1238    1267 ..    1224    1279 .. 0.79
   2 !   35.7   0.2   3.1e-12   1.1e-08       1     106 [.    1403    1510 ..    1403    1511 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.88
       VWA_2   30 allkslpgdrvglvtfsdgpevlipltkdk 59  
                  ++++sl  ++ g+vtf   p+v+++ ++++
  EFC39305.1 1238 SIVSSLTISTSGVVTFTRLPTVITGTCTMN 1267
                  6788889999**********9999876554 PP

  == domain 2  score: 35.7 bits;  conditional E-value: 3.1e-12
       VWA_2    1 lvfvlDtSgSmrngdygptrleaakdaveallksl...pgd..rvglvtfsdgpevlipltkdkakilnalrnleakgggtnlaaaLqlarkalkkr 92  
                  +vf+lD SgS++++     ++  ++ + +++ +++     d   v++v f +++++ ++l+ d ++i+n l n+ +++  t +  +L+ a +al+  
  EFC39305.1 1403 FVFLLDASGSIGTT-----NYNSMRTLCKQITGRMsisS-DsiLVSIVRFHSNATLALKLSNDGTTINNTLTNMAYEASSTGTIPGLRVAVDALRPA 1493
                  59***********8.....79999999999999885532.257***************************************************666 PP

       VWA_2   93 r...kgekrvivlitDg 106 
                  +     + +vi+++tDg
  EFC39305.1 1494 NggrDDADKVIFILTDG 1510
                  666799**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1682 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       939  (0.0523733); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.85u 0.27s 00:00:01.12 Elapsed: 00:00:00.50
# Mc/sec: 10145.17
//
Query:       EFC39306.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-06   28.6   2.1    1.8e-06   28.2   0.6    1.9  2  RNase_H   RNase H
  ------ inclusion threshold ------
      0.017   15.8   0.5      0.064   14.0   0.1    2.2  2  zf-RVT    zinc-binding in reverse transcriptase


Domain annotation for each model (and alignments):
>> RNase_H  RNase H
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.2   0.6     2e-10   1.8e-06       2     140 ..       8     133 ..       7     136 .. 0.68
   2 ?   -2.3   0.0      0.52   4.7e+03     101     122 ..     303     324 ..     277     328 .. 0.77

  Alignments for each domain:
  == domain 1  score: 28.2 bits;  conditional E-value: 2e-10
                 .SEEEEEEEEEECTTTCEEEEEEECTT..EEEEEEECCCCHHHHHHHHHHHHHHHTT.SCSEEEEEES-HHHHHHHHCCCHHHHHTTSSSETTSSBHTT CS
     RNase_H   2 kavvvYtDGsclgnpgeggagavlykegarnisapleeaqtnnraELsAvieaLkalksdekvniytDSkYvvkgitqwvhrwkknawkttseqkpvkn 100
                 +++++ tDGs +   +egg+g+v++k+  ++i  +  +a +    E++A++ a+k   ++ +++i tDS   +k i   +++ +k +++       vk+
  EFC39306.1   8 ENMIIATDGSFK--DNEGGIGIVTEKG--EKINMNAFAAASSFDCEIQAIYIACKM--TKGNIQILTDSMASIK-I---IEGDRKTNNPY------VKA 90 
                 6899******66..889*******988..555555556899999***********8..7889*******77777.3...44433333333......333 PP

                 ..HHHHHHHHHCHCSSEEEEEE-SCCSSS..THHHHHHHHHHHH CS
     RNase_H 101 ..kdlaellkelakkkkvqlkwvkgHaGv..pkgNemaDrlAke 140
                   k+ + +  +++k ++v+ +    H+     + N++aD  A++
  EFC39306.1  91 irKEKQRITLRHIKSHQVETQQMT-HEEKvlIQLNNEADIEANR 133
                 334444555556777777777654.5433344567777766665 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.52
                 HHHHHHHHHCHCSSEEEEEE-S CS
     RNase_H 101 kdlaellkelakkkkvqlkwvk 122
                 k+++++l++  k++++q++ +k
  EFC39306.1 303 KEVYQTLEAWDKAQEIQIEIIK 324
                 6788888888888888888776 PP

>> zf-RVT  zinc-binding in reverse transcriptase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.1       1.1   9.4e+03      30      53 ..      94     117 ..      81     122 .. 0.70
   2 ?   14.0   0.1   7.1e-06     0.064      16      82 ..     183     252 ..     169     254 .. 0.64

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.1
      zf-RVT  30 pkvkfflWlllknrlptadnllkr 53 
                  k ++ l+ + +++++t+++ ++ 
  EFC39306.1  94 EKQRITLRHIKSHQVETQQMTHEE 117
                 566777777777777777776655 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 7.1e-06
      zf-RVT  16 kvklakliWkskappkvkfflWlllknrlpta.dnllkrgies.ssrCqlCgqe.eEtieHlfleCpfak 82 
                 + + +++i ks+++pk k ++   ++ +   a + l +++i +  + C++ + + eE+++H++++C++++
  EFC39306.1 183 NLNAFSKIRKSRIIPKNKTITKNQINIATRAAfNSLPTNNIFTpGNGCPIRDCKeEENTQHAIFNCKKTE 252
                 34667778888888888888775555333322122334444432567999777769**********9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1006  (0.0561102); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2306.91
//
Query:       EFC39307.1  [L=217]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-06   28.1 115.1     0.0069   16.4  35.3    3.8  4  Trypan_PARP  Procyclic acidic repetitive protein (PARP)
  ------ inclusion threshold ------
        1.7    7.3  10.9        1.7    7.3  10.9    1.2  1  Presenilin   Presenilin


Domain annotation for each model (and alignments):
>> Trypan_PARP  Procyclic acidic repetitive protein (PARP)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.7     0.027   2.4e+02      67      90 ..       2      26 ..       1      46 [. 0.36
   2 !   16.4  35.3   7.7e-07    0.0069      47     111 ..      39      99 ..      22     104 .. 0.39
   3 !    7.3  41.9    0.0005       4.5      59     110 ..     102     153 ..      97     155 .. 0.43
   4 !   16.2  34.8   8.9e-07     0.008      60     115 ..     141     196 ..     140     205 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.027
  Trypan_PARP 67 pepepepe.pepepetepeeepepe 90
                 p+p+p+p  ++ + +t+ + +++ +
   EFC39307.1  2 PNPNPNPTqTQTQTQTQTQTQTQTQ 26
                 3333333312222222222222222 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 7.7e-07
  Trypan_PARP  47 tkvsdddtngtdpepepepepepepepepepepetepeeepepepepepepepepepepepepep 111
                  t+ + +    t+++p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p    +p
   EFC39307.1  39 TQTQTQTQTQTQTQPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKP----KP 99 
                  22222222333334444444443333333333333333333333333333333333333....32 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0005
  Trypan_PARP  59 pepepepepepepepepepepetepeeepepepepepepepepepepepepe 110
                  p+p+p p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+
   EFC39307.1 102 PKPKPPPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPK 153
                  3344444444444444444444444444444444444444444444444444 PP

  == domain 4  score: 16.2 bits;  conditional E-value: 8.9e-07
  Trypan_PARP  60 epepepepepepepepepepetepeeepepepepepepepepepepepepepgaat 115
                  +p+p+p+p+p+p+p+p+p+p+++p+++p+p+p+p+p+p+p+p+p+p+p+p+p   t
   EFC39307.1 141 KPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKPKCQT 196
                  57777777777777777777778888888888888888888888888888887766 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3  10.9   0.00019       1.7     240     293 ..      12      60 ..       2     170 .. 0.57

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00019
  Presenilin 240 eaekkkeeasesskeeeseeesseksaqsseseeeseeesseaessaeesseek 293
                 +++++++++++++++++++     ++aq++++++++++++++++++++ + ++k
  EFC39307.1  12 QTQTQTQTQTQTQTQTQTQ-----TRAQTQTQTQTQTQTQTQTQTQPKPKPKPK 60 
                 1111111111111111111.....111111111111111111111111111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (217 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2735  (0.152546); expected 358.6 (0.02)
Passed bias filter:                      846  (0.0471861); expected 358.6 (0.02)
Passed Vit filter:                       239  (0.0133304); expected 17.9 (0.001)
Passed Fwd filter:                        78  (0.00435049); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.30u 0.36s 00:00:01.66 Elapsed: 00:00:00.55
# Mc/sec: 1184.71
//
Query:       EFC39308.1  [L=411]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    0.00041   20.0   1.6       0.86    9.1   0.0    3.0  3  NopRA1        Nucleolar pre-ribosomal-associated protein 1
  ------ inclusion threshold ------
      0.034   14.1   0.3      0.073   13.0   0.3    1.5  1  CSN7a_helixI  COP9 signalosome complex subunit 7a helix I dom


Domain annotation for each model (and alignments):
>> NopRA1  Nucleolar pre-ribosomal-associated protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.8   0.0   0.00013       1.1       2      52 ..      90     141 ..      89     182 .. 0.71
   2 !    9.1   0.0   9.6e-05      0.86     132     201 .]     273     348 ..     240     348 .. 0.78
   3 ?   -0.8   0.1      0.11   9.7e+02      28      65 ..     358     400 ..     350     409 .. 0.58

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00013
      NopRA1   2 gllvlsLssedeeirrlAlavlskllasleesss.fkektqlllllsellet 52 
                 +++++  +s+d  +r+lA+++++ +++ + +  +  +e++++ +l+  l++ 
  EFC39308.1  90 SIAFRGTCSNDYYVRMLAYEIIGMYYNFIVNHVNrNQESDIYEVLVLVLRQV 141
                 678999********************99954333367887777777666662 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 9.6e-05
      NopRA1 132 iLrlladGlrtksDlk.llkrrrvfe.lllslynspll...daklrelilelllr.atrieggattLitrsGllsW 201
                 +L++l  G +t++D++  + ++++++ ll+s+ + +++   +   + +i ++l   +tr+ +  ++L++ ++l+ W
  EFC39308.1 273 YLKVLLYGYQTDEDFMdEYIKNNTIQhLLMSFDQLESSksyQVYQQISICRILIDvITRLRKSREKLLKDFALIDW 348
                 5899**********8775555555550555555444443335577799999998857888899**********999 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.11
      NopRA1  28 asleesssfkek......tqlllllselletllaskseeeekep 65 
                 + + +s++f ++      + l++l++++ +t++ +++ ++++ +
  EFC39308.1 358 NLIISSQTFNSRnnneiiRLLMILICSIYNTSN-NGNTSNNNSN 400
                 444455556666666666778888888888666.3333333444 PP

>> CSN7a_helixI  COP9 signalosome complex subunit 7a helix I domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.3   8.1e-06     0.073      16      44 ..     164     192 ..     160     195 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 8.1e-06
  CSN7a_helixI  16 CeaiLsciEtqverANaeknkaikhkeki 44 
                   C+ iL+++E++ ++ N++k  ++k   k+
    EFC39308.1 164 CNSILKSVEDNSNNSNNNKYDNNKYDSKY 192
                   *******************9998876666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (411 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1653  (0.092197); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2398.53
//
Query:       EFC39309.1  [L=703]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.6e-17   61.5   0.0    1.9e-16   60.2   0.0    1.7  1  Copine         Copine
    0.00093   19.4   0.7     0.0064   16.6   0.2    2.4  2  vWA-TerF-like  vWA found in TerF C terminus
  ------ inclusion threshold ------
      0.047   14.0   0.0       0.15   12.4   0.0    1.8  1  C2             C2 domain
      0.085   12.6   0.3       0.19   11.5   0.3    1.5  1  DUF5127        Domain of unknown function (DUF5127)


Domain annotation for each model (and alignments):
>> Copine  Copine
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.2   0.0   4.3e-20   1.9e-16       6     196 ..     512     695 ..     499     701 .. 0.78

  Alignments for each domain:
  == domain 1  score: 60.2 bits;  conditional E-value: 4.3e-20
      Copine   6 speqpneYekallsvgeilqaydsdklipafGFGaklpsdaevsdefvlnfneenkevegiegvleaYrealpnlqlygPTnfapviekvakiaeasak 104
                 sp+ +n+Yek ++ +++ + +y  +++++ +GFGa l++++ ++ ++   ++ +++ ++  + +l++Yr++++++ l    nf+++i +va +ae+   
  EFC39309.1 512 SPNPLNPYEKCMVGIMRAVYQYGYQREMKMYGFGA-LAPNVVFEMQEKKRVA-RESGIRDEKTMLHTYRRTVKKVLLGLENNFTKIIAEVAAFAER--- 605
                 466789*****************************.7777666666555554.4567888899********************************9... PP

      Copine 105 easqYfvLliitDGvvt.dmketidaivaAsklplSiiivGvGdad.fekmrelddddalkssdgriakRdivqfVdfrdlksnasakeaalak 196
                   ++Yf+ +iitDG    + k t + + +     +S + vGvG++  f+++ +++ +    ++ + +   d+++  +++ l + ++++++ la+
  EFC39309.1 606 -LNHYFICVIITDGDEGiNRKLTLQLLKQSQLCGVSFVFVGVGNKSlFKNLMSFQTN---CRNVTFVKYNDNMELNAMNALREVQQHAREYLAQ 695
                 .899**********99857777777666666668*********87559999999999...3334444455777777777777766666666665 PP

>> vWA-TerF-like  vWA found in TerF C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.21   9.5e+02     135     168 ..     382     415 ..     374     420 .. 0.89
   2 !   16.6   0.2   1.4e-06    0.0064      57     155 ..     564     661 ..     548     690 .. 0.68

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.21
  vWA-TerF-like 135 FwqFvglgkseygvLeklDdlegRvvDNagFfav 168
                    +w F  +gk+e+  + + D l+ R++  ++F  v
     EFC39309.1 382 WWHFNEFGKNEFIGIVRTDILDMREHQTCEFKIV 415
                    69**********9999*********999999655 PP

  == domain 2  score: 16.6 bits;  conditional E-value: 1.4e-06
  vWA-TerF-like  57 dvtladleeyvkeeeegllelkklggvneeapvleevlekvrkepaelptlvlFitDGgvkkkkeie.kalreaskepiFwqFvglgkse.ygvLe 150
                    +  ++d ++++++ ++   +   lg +n+ +++++ev++ ++  + +   + + itDG+   +++ + ++l++++   + + Fvg+g+++ ++ L 
     EFC39309.1 564 ESGIRDEKTMLHTYRRTV-KKVLLGLENNFTKIIAEVAAFAE--RLNHYFICVIITDGDEGINRKLTlQLLKQSQLCGVSFVFVGVGNKSlFKNLM 656
                    455566666665554444.44468999**********99888..55556778899***98777655516667777789**********99999999 PP

  vWA-TerF-like 151 klDdl 155
                     + + 
     EFC39309.1 657 SFQTN 661
                    88763 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.2e-05      0.15       7      92 ..     317     405 ..     311     414 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.2e-05
                 EEEEESSSSSST.TSSCEEEEEEEE...ECEEEEEE-.SCSSSSSSEEEEEEEEEESC..HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHH CS
          C2   7 vieAknLpnkdk.kgssdpyvkvsl...dgkqkakTr.viknslnPvWnekftfevae..leeakLeveVfdndrlskddfiGkveiplstll 92 
                 +  A  L   d  ++s++py  v+    + kq+  T+ ++k+s n ++   f+f ++   + ++++ +e ++++ ++k++fiG v+ ++ ++ 
  EFC39309.1 317 IRDAPIL---DRfSSSCSPYFIVYKdgvKFKQRLYTSeIKKKSPNSTY-RVFSFGLEGerSLDKSMLIEWWHFNEFGKNEFIGIVRTDILDMR 405
                 4444434...333778999*9999955533333334325699999999.77777666666999**********************99987644 PP

>> DUF5127  Domain of unknown function (DUF5127)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.3   4.2e-05      0.19       4      54 ..     126     176 ..     124     193 .. 0.93

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 4.2e-05
     DUF5127   4 iftftaggkveltvtFlSPvlpddldrqSlpfsYltvevkstdgkshsVqv 54 
                 +f+f + +k+++ + F+SP   + l+ qS  fs   ++ + + g+sh+V v
  EFC39309.1 126 TFQFGCVQKMKIFIRFVSPKDAKQLTSQSQSFSQSFYKYNNQMGSSHNVLV 176
                 588999999***************************************976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (703 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       601  (0.0335211); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 3865.76
//
Query:       EFC39310.1  [L=436]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.72   10.1   3.2       0.43   10.9   0.3    2.3  2  DUF3007   Protein of unknown function (DUF3007)


Domain annotation for each model (and alignments):
>> DUF3007  Protein of unknown function (DUF3007)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.3   2.4e-05      0.43      37      75 ..      11      53 ..       4     113 .. 0.83
   2 ?   -2.4   0.2      0.32   5.7e+03      70      92 ..     231     253 ..     226     257 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 2.4e-05
     DUF3007 37 wsqavlvlglvgWvltYll....RvvtkkmTyaqqlkdyeeav 75
                 sq+  v+ ++ W++ +l      v  +  Ty+qq+++y++  
  EFC39310.1 11 SSQLNYVIKIIKWIFNFLNgllnGVQWNFITYKQQKEEYRKIK 53
                578899***********9844445666789*********9865 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.32
     DUF3007  70 dyeeavl.qkrleeltpeelekLq 92 
                 +ye+ v+ qk ++++++e+ e L+
  EFC39310.1 231 EYEQSVFtQKSMQDIEQEN-ETLN 253
                 6888885377788877766.6655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (436 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1428  (0.0796475); expected 358.6 (0.02)
Passed bias filter:                      329  (0.0183502); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 2403.64
//
Query:       EFC39311.1  [L=454]
Description: hypothetical protein NAEGRDRAFT_81296 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.085   12.7   0.0       0.33   10.9   0.0    2.0  2  DUF433    Protein of unknown function (DUF433)


Domain annotation for each model (and alignments):
>> DUF433  Protein of unknown function (DUF433)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       0.5     9e+03      30      41 ..     165     176 ..     159     182 .. 0.61
   2 ?   10.9   0.0   1.8e-05      0.33      13      40 ..     290     317 ..     286     323 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.5
                 TT--HHHHHHHH CS
      DUF433  30 aGesieeiledy 41 
                 +G + eei + y
  EFC39311.1 165 EGLTAEEIDKIY 176
                 466666665555 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 1.8e-05
                 EETTT--BTHHHHHHHHTT--HHHHHHH CS
      DUF433  13 vIrgtRipVetilellaaGesieeiled 40 
                 + +   ipV++ile + +G  +eei+++
  EFC39311.1 290 ILKKKNIPVDFILESYVSGIPVEEIARQ 317
                 667889*******************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (454 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1848  (0.103073); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.36s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 2547.69
//
Query:       EFC39312.1  [L=124]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.8e-27   93.6   0.7    8.3e-27   93.3   0.7    1.1  1  Ribosomal_S10  Ribosomal protein S10p/S20e
  ------ inclusion threshold ------
       0.12   12.6   0.4       0.33   11.1   0.3    1.8  2  CinA_KH        Damage-inducible protein CinA KH domain


Domain annotation for each model (and alignments):
>> Ribosomal_S10  Ribosomal protein S10p/S20e
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.3   0.7   9.3e-31   8.3e-27       1      98 []      25     120 ..      25     120 .. 0.98

  Alignments for each domain:
  == domain 1  score: 93.3 bits;  conditional E-value: 9.3e-31
                    EEEEEESSHHHHHHHHHHHHHHTTSSS-E.E---EEEEEEEEEEEEE--SS--.S--EEEEEEEEEEEEEEEE.E-HHHHHHHS-...S---SS-E CS
  Ribosomal_S10   1 rirlkSydsklLekavkkivraakelgik.vkgpvplPtkrkrvtvlksphvd.kksreqfeirthkRlidisdatketidtllkllqlnlpegVs 94 
                    ri+l++ + k+Lek++ ++vr ak++++k vkgpv++Ptk +++t++ksp+++ ++++++fe+ +hkR+id+ +a+++t++++++   +++++ V+
     EFC39312.1  25 RITLTAKNVKALEKVCADFVREAKNKKVKrVKGPVRMPTKILKITTRKSPCGEgTNTWDKFEMSVHKRVIDL-HAPASTVKDITS---ISMEPNVE 116
                    89**********************************************************************.5***********...9999**** PP

                    EEEE CS
  Ribosomal_S10  95 vevk 98 
                    +e++
     EFC39312.1 117 IEIT 120
                    *996 PP

>> CinA_KH  Damage-inducible protein CinA KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.3   3.7e-05      0.33      37      65 ..      21      49 ..      12      55 .. 0.89
   2 ?   -1.1   0.0      0.24   2.2e+03       7      21 ..      82      96 ..      65     121 .. 0.63

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 3.7e-05
                EEEEEEE...EEHHHHHHHHH....HHHH CS
     CinA_KH 37 evtvRltakaaneeeaealiapveeeire 65
                  ++R+t  a+n ++ e+++a++++e ++
  EFC39312.1 21 IHRIRITLTAKNVKALEKVCADFVREAKN 49
                568**********************9987 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 0.24
                -S--HHHHHHHHGGG CS
     CinA_KH  7 fGigESavaekladl 21
                +   E +v +++ dl
  EFC39312.1 82 WDKFEMSVHKRVIDL 96
                444455555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (124 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       797  (0.0444531); expected 358.6 (0.02)
Passed bias filter:                      528  (0.0294495); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 770.09
//
Query:       EFC39313.1  [L=777]
Description: EVH1 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.2e-60  202.1  12.9    7.2e-60  202.1  12.9    2.6  2  SMK-1     Component of IIS longevity pathway SMK-1


Domain annotation for each model (and alignments):
>> SMK-1  Component of IIS longevity pathway SMK-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  202.1  12.9     4e-64   7.2e-60       2     191 .]     206     395 ..     205     395 .. 0.99
   2 ?    1.0   0.1     0.018   3.3e+02       3      24 ..     650     671 ..     648     694 .. 0.89

  Alignments for each domain:
  == domain 1  score: 202.1 bits;  conditional E-value: 4e-64
       SMK-1   2 edYikkLlelfeeaedleslenLhalcsivktilllndeelleellsdelilgvvGilEydpefpehkanhRefLkqkakfkevipikdeelkkkihqt 100
                 +dYi kL+++f+++edl+s+en+ +l++i+  i+ ++d e+le+l+s ++i++++G+lEydp++p++kanhR+fL++++ fkevip++++++++kihqt
  EFC39313.1 206 SDYILKLFQVFDDCEDLDSVENCRILFKIFSGIIAIDDLEILEILFSKNNIMKLIGVLEYDPDLPTKKANHRNFLNNRVIFKEVIPFNNHNVLDKIHQT 304
                 79************************************************************************************************* PP

       SMK-1 101 yrlqylkDvvLarvlddstlsvLnsliffnqveIvsllqedeefLkelfkllkdeetekekrrelvlllkelcslaknlqlpareelfktL 191
                 +++qy+k+++La+++dd+t+s+L+++if n++ I++ ++ed+efLk++f++l  ++t k+k+r+l ++l e+++l k+ + +++ + +k+L
  EFC39313.1 305 FKIQYIKETILASIIDDQTFSTLSTIIFKNNTMIINSIKEDQEFLKKVFSTLLADDTPKDKQRDLSKFLSEFFALLKHQNINNKIDTYKRL 395
                 *************************************************************************************999986 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.018
       SMK-1   3 dYikkLlelfeeaedleslenL 24 
                 +Y++++ +l+ee++++e+ en 
  EFC39313.1 650 NYVETFAQLIEECDQQENSENN 671
                 8****************99985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (777 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1285  (0.0716716); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.76u 0.32s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 4467.38
//
Query:       EFC39314.1  [L=475]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-46  156.1  28.2    7.3e-12   44.8   0.2   10.3 12  DUF4116      Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.083   13.5   0.1        0.2   12.3   0.1    1.7  1  DUF4296      Domain of unknown function (DUF4296)
      0.083   13.3   0.1       0.98    9.9   0.0    2.5  2  ACP_PD       Acyl carrier protein phosphodiesterase
        0.1   12.8   0.1        1.6    8.9   0.0    2.4  2  Fe-S_biosyn  Iron-sulphur cluster biosynthesis
       0.36   11.0   2.3        1.4    9.1   0.2    2.9  3  KIP1         KIP1-like protein


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.1   9.2e-06     0.033       9      40 ..      48      80 ..      46      84 .. 0.87
   2 !   44.8   0.2     2e-15   7.3e-12       1      48 [.      88     135 ..      88     146 .. 0.97
   3 !   16.0   0.0   2.1e-06    0.0074       4      37 ..     156     189 ..     154     193 .. 0.92
   4 !   30.4   1.1   6.7e-11   2.4e-07       3      46 ..     180     223 ..     178     227 .. 0.91
   5 !   20.5   0.1   8.2e-08    0.0003       1      49 []     203     252 ..     203     252 .. 0.96
   6 !   26.1   0.0   1.5e-09   5.2e-06       2      49 .]     230     277 ..     229     277 .. 0.94
   7 !   19.6   0.3   1.5e-07   0.00055       1      37 [.     254     290 ..     254     299 .. 0.88
   8 !   13.3   0.4   1.4e-05     0.051      16      34 ..     290     308 ..     279     314 .. 0.77
   9 !   27.3   0.2     6e-10   2.1e-06       1      39 [.     300     343 ..     300     346 .. 0.85
  10 !    4.6   0.0    0.0076        27      25      40 ..     346     361 ..     344     368 .. 0.81
  11 !    8.9   0.0   0.00033       1.2       3      18 ..     371     386 ..     369     391 .. 0.81
  12 ?   -1.4   0.1      0.56     2e+03       1      11 [.     435     445 ..     435     449 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 9.2e-06
     DUF4116  9 vkkngsalkylseeLkn.DkeivlkAvkqngta 40
                +  n+++l+++ +++k  D+e+vl+A++++ +a
  EFC39314.1 48 INLNPKVLRFVKNRWKElDREVVLQALRKDIIA 80
                6679***********999**********98665 PP

  == domain 2  score: 44.8 bits;  conditional E-value: 2e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 DrE++l +v++n++alky    ++nDkeivlkA+ qn++ l ya++++
  EFC39314.1  88 DREMALLVVETNPLALKYEHGVWQNDKEIVLKAISQNKNLLVYACDSI 135
                 9*******************************************9975 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 2.1e-06
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 +vl+ vk  +s ++yl+e +k + e+v+k v+ +
  EFC39314.1 156 LVLNGVKEKPSLFNYLPEHMKTNHEFVIKLVELD 189
                 89999*************************9865 PP

  == domain 4  score: 30.4 bits;  conditional E-value: 6.7e-11
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 E+v ++v+ +  + ++++e+Lk+++e++++ vk + +a++ + +
  EFC39314.1 180 EFVIKLVELDTRISEFIPESLKQNREFLMELVKYDRNAFYNCKD 223
                 9************************************9987765 PP

  == domain 5  score: 20.5 bits;  conditional E-value: 8.2e-08
     DUF4116   1 DrEivleavkkngsalkyl.seeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +rE+ +e+vk + +a++++ + +L+  ++++l A+  + ++ls a+ +L+
  EFC39314.1 203 NREFLMELVKYDRNAFYNCkDMDLRGSRQFLLNALSTYRFSLSSAPSHLK 252
                 8******************6689***********************9997 PP

  == domain 6  score: 26.1 bits;  conditional E-value: 1.5e-09
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 r++ l+a++++ ++l  +++ Lk Dke+v++++  ++  l+ as  Lr
  EFC39314.1 230 RQFLLNALSTYRFSLSSAPSHLKDDKEFVMECLTAYPADLDEASSRLR 277
                 89*******************************999999999998876 PP

  == domain 7  score: 19.6 bits;  conditional E-value: 1.5e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 D+E+v+e+++ ++  l  +s++L+ D ++v   +k  
  EFC39314.1 254 DKEFVMECLTAYPADLDEASSRLRDDEQVVELVLKEF 290
                 9*****************************9998854 PP

  == domain 8  score: 13.3 bits;  conditional E-value: 1.4e-05
     DUF4116  16 lkylseeLknDkeivlkAv 34 
                 ++++s++Lk Dk++v+k +
  EFC39314.1 290 FNNASNRLKDDKDFVMKHI 308
                 788*************966 PP

  == domain 9  score: 27.3 bits;  conditional E-value: 6e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk.....qngt 39 
                 D+++v++ ++ ++  ++ ls +Lk+Dkei+lk+       +ng+
  EFC39314.1 300 DKDFVMKHIEEFPQMYQSLSQRLKSDKEIILKCASgggviSNGY 343
                 9*******************************954333336666 PP

  == domain 10  score: 4.6 bits;  conditional E-value: 0.0076
     DUF4116  25 nDkeivlkAvkqngta 40 
                 +D ++vl+ v++n ++
  EFC39314.1 346 HDDDFVLELVERNAHI 361
                 5899999999999765 PP

  == domain 11  score: 8.9 bits;  conditional E-value: 0.00033
     DUF4116   3 Eivleavkkngsalky 18 
                 E++++++++ng++++ 
  EFC39314.1 371 EFAKKCIERNGFCYHL 386
                 8899999999998875 PP

  == domain 12  score: -1.4 bits;  conditional E-value: 0.56
     DUF4116   1 DrEivleavkk 11 
                 DrEiv   +kk
  EFC39314.1 435 DREIVDSWIKK 445
                 88888888887 PP

>> DUF4296  Domain of unknown function (DUF4296)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   5.6e-05       0.2      37      85 ..     277     326 ..     259     328 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 5.6e-05
     DUF4296  37 k.keayyeavlkkygitsaefdsSlvyYsrnpeelekiyekvedrlkkek 85 
                 +  e++ e vlk+++  s+ +++   + ++++ee+ ++y+++++rlk++k
  EFC39314.1 277 RdDEQVVELVLKEFNNASNRLKDDKDFVMKHIEEFPQMYQSLSQRLKSDK 326
                 1367899****************************************987 PP

>> ACP_PD  Acyl carrier protein phosphodiesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00027      0.98      26      84 ..     119     177 ..     114     201 .. 0.75
   2 ?    0.4   0.0      0.25   8.9e+02      61      95 ..     286     321 ..     259     326 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00027
      ACP_PD  26 aqlekneealPerlqrllprmieedwLesYaelegieralqrmarrlkrasklaeaiee 84 
                 +++++n++ l     +++++  +++ L +Y++ + i+ +l++++++++  + l e +++
  EFC39314.1 119 KAISQNKNLLVYACDSIIEEVLRNRELIEYSQEDVINLVLNGVKEKPSLFNYLPEHMKT 177
                 6788899999999999*******************************999955444433 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.25
      ACP_PD  61 ieralqrmarrlkrask.laeaieeleenyaelead 95 
                 + + +++ ++rlk +++ + + iee+ + y+ l++ 
  EFC39314.1 286 VLKEFNNASNRLKDDKDfVMKHIEEFPQMYQSLSQR 321
                 445556666666666655666667777777766654 PP

>> Fe-S_biosyn  Iron-sulphur cluster biosynthesis
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.13   4.6e+02      56     105 ..      63     112 ..      25     117 .. 0.71
   2 ?    8.9   0.0   0.00046       1.6      11      54 ..     316     358 ..     312     392 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.13
                  TTTEEEEE.ETTEEEEEEGGGHHHS.TTEEEEEEEETTEEEEEEETCCEEE CS
  Fe-S_biosyn  56 eeydevle.snggkvyvksyslvfldeglvldfvedlgtlgLksdngildd 105
                  +e d ++  +++ k ++  ysl+ ld ++ l +v +++ l Lk + g+ ++
   EFC39314.1  63 KELDREVVlQALRKDIIAIYSLQALDREMALLVV-ETNPLALKYEHGVWQN 112
                  5555555547777778888999999999999999.7888888888877665 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00046
                  HHHHHHHHCTTECEEEEEECCTSCCGGS..TT.EEEEEEEEESST CS
  Fe-S_biosyn  11 eklkkllaedkkelrLdvddgggpyskgg.Csiggkyslvlvdee 54 
                  + l++ l++dk+ ++L+   ggg  s+g   + ++++ l+lv+++
   EFC39314.1 316 QSLSQRLKSDKE-IILKCASGGGVISNGYfFH-DDDFVLELVERN 358
                  678999999999.**************88799.********9987 PP

>> KIP1  KIP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.61   2.2e+03      32      64 ..     144     176 ..     132     184 .. 0.71
   2 ?   -0.6   0.1       0.4   1.4e+03      24      60 ..     176     212 ..     159     224 .. 0.68
   3 ?    9.1   0.2    0.0004       1.4      45      72 ..     294     321 ..     268     323 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.61
        KIP1  32 klieedadsfakraemyykkrpeLielveefyr 64 
                 +lie  +++  +   +  k++p L++ + e  +
  EFC39314.1 144 ELIEYSQEDVINLVLNGVKEKPSLFNYLPEHMK 176
                 466666666666677778888888888876655 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.4
        KIP1  24 dekvkemlklieedadsfakraemyykkrpeLielve 60 
                  ++ + ++kl+e d   ++   e   ++r+ L+elv+
  EFC39314.1 176 KTNHEFVIKLVELDTRISEFIPESLKQNREFLMELVK 212
                 4445556666666666666666667777777777775 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.0004
        KIP1  45 aemyykkrpeLielveefyrsyrsLaer 72 
                  +     ++ +++++eef ++y+sL +r
  EFC39314.1 294 SNRLKDDKDFVMKHIEEFPQMYQSLSQR 321
                 444455678899*************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (475 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       850  (0.0474092); expected 358.6 (0.02)
Passed bias filter:                      545  (0.0303977); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.50
# Mc/sec: 2874.34
//
Query:       EFC39315.1  [L=842]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00016   21.3  16.3    0.00016   21.3  16.3    4.7  3  Collagen  Collagen triple helix repeat (20 copies)


Domain annotation for each model (and alignments):
>> Collagen  Collagen triple helix repeat (20 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -33.1  83.6         1   1.8e+04       1      58 [.      49     106 ..      10     114 .. 0.80
   2 ?   -4.4  32.8      0.99   1.8e+04       8      44 ..     133     169 ..     130     176 .. 0.52
   3 !   21.3  16.3   9.1e-09   0.00016      16      49 ..     181     214 ..     177     217 .. 0.40

  Alignments for each domain:
  == domain 1  score: -33.1 bits;  conditional E-value: 1
                 XXXXXXXXXXXXXXXXXX-----XXXXEEEE-TTSS-----------------BB--X CS
    Collagen   1 GppGepGepGppGppGkrGepGeaGekGekGpaGekGppGaaGkpGapGekGeaGapg 58 
                 G+pG pG +G++G +G rG pG  G  G kG +G++G +G+ G +G +G++G +G +g
  EFC39315.1  49 GEPGGPGGDGENGGKGGRGGPGGMGGVGGKGGTGARGGNGSSGGNGMNGQDGGNGGNG 106
                 6677777777777777777777777777777777777777777777777777666655 PP

  == domain 2  score: -4.4 bits;  conditional E-value: 0.99
                 XXXXXXXXXXX-----XXXXEEEE-TTSS-------- CS
    Collagen   8 epGppGppGkrGepGeaGekGekGpaGekGppGaaGk 44 
                 +pG+ G++Gk G++G+aG+ GekGp G+ G+ Ga G+
  EFC39315.1 133 QPGKGGMDGKGGSAGSAGKGGEKGPGGPGGRGGAGGA 169
                 3455555555555555555555555555555554443 PP

  == domain 3  score: 21.3 bits;  conditional E-value: 9.1e-09
                 XXX-----XXXXEEEE-TTSS------------- CS
    Collagen  16 GkrGepGeaGekGekGpaGekGppGaaGkpGapG 49 
                 G++G++G++G++G+kG++G+kG+pG++G++G+pG
  EFC39315.1 181 GSNGRNGSDGKSGQKGQEGRKGNPGHTGQDGTPG 214
                 3333333333333333333333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (842 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       546  (0.0304535); expected 358.6 (0.02)
Passed bias filter:                      408  (0.0227564); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 4969.65
//
Query:       EFC39316.1  [L=1219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.3e-60  197.7   9.4    5.2e-07   29.4   0.1   13.2 14  NHL             NHL repeat
    9.3e-17   61.0   4.2      0.047   13.9   0.0    7.9 10  Arylesterase    Arylesterase
    1.2e-09   38.3 102.4    0.00065   20.0   9.1    6.1  6  EGF_2           EGF-like domain
     0.0001   22.6   0.3    1.8e+02    2.6   0.0    7.0  7  Linker_histone  linker histone H1 and H5 family
     0.0019   18.5  72.4       0.11   12.8   7.1    5.9  5  EGF             EGF-like domain
  ------ inclusion threshold ------
       0.39   10.3  11.4          6    6.4   0.1    5.0  6  GTP1_OBG        GTP1/OBG
          2    9.2  80.7       0.05   14.3   6.4    6.6  7  hEGF            Human growth factor-like EGF
        3.5    8.8   5.3         44    5.3   0.6    4.3  3  PPC             Bacterial pre-peptidase C-terminal domain
        5.9    7.0   7.9    1.3e+02    2.7   0.0    5.1  7  SBDS            Shwachman-Bodian-Diamond syndrome (SBDS) prot


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.0     0.054   1.1e+02      16      27 ..      39      50 ..      32      51 .. 0.90
   2 !   29.4   0.1   2.6e-10   5.2e-07       1      27 [.      80     107 ..      80     108 .. 0.96
   3 !   28.1   0.0   6.6e-10   1.3e-06       1      27 [.     137     164 ..     137     165 .. 0.95
   4 !    9.0   0.0   0.00073       1.5       2      27 ..     195     219 ..     194     220 .. 0.85
   5 !   21.0   0.0   1.2e-07   0.00024       1      27 [.     250     277 ..     250     278 .. 0.93
   6 !   13.6   0.0   2.6e-05     0.052       2      27 ..     307     332 ..     306     333 .. 0.95
   7 !   10.7   0.0   0.00022      0.43       3      27 ..     363     387 ..     363     388 .. 0.94
   8 !   29.2   0.0   2.9e-10   5.8e-07       1      27 [.     417     444 ..     417     445 .. 0.95
   9 !   11.1   0.0   0.00016      0.33       1      26 [.     474     500 ..     474     501 .. 0.96
  10 !    6.1   0.0    0.0064        13      14      28 .]     544     558 ..     532     558 .. 0.89
  11 !   25.2   0.0   5.7e-09   1.1e-05       1      27 [.     587     614 ..     587     615 .. 0.96
  12 ?    0.6   0.1      0.35   6.9e+02       2      23 ..     645     666 ..     645     671 .. 0.80
  13 ?   -3.2   0.1       5.7   1.1e+04       5      11 ..     759     765 ..     756     767 .. 0.64
  14 ?   -2.4   0.1         3   5.9e+03       5      12 ..     828     835 ..     828     835 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.054
                EEEECCCTEEEE CS
         NHL 16 yVaDsenhrvqv 27
                ++aD  nhr+++
  EFC39316.1 39 LIADATNHRIRK 50
                79********86 PP

  == domain 2  score: 29.4 bits;  conditional E-value: 2.6e-10
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P G+ vd ++ ++y+aDs+nhr+++
  EFC39316.1  80 LNNPVGIYVDtNSREVYIADSNNHRIRK 107
                 79************************97 PP

  == domain 3  score: 28.1 bits;  conditional E-value: 6.6e-10
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n P+G+++d +nG+i+++Ds+nhr+++
  EFC39316.1 137 LNTPSGIVIDpNNGEIFISDSKNHRIRK 164
                 789***********************97 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00073
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 + P+G+ +    ++++aD +nhr+++
  EFC39316.1 195 YLPNGIDL-YEKELFIADQNNHRIRK 219
                 66888888.5899***********86 PP

  == domain 5  score: 21.0 bits;  conditional E-value: 1.2e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 ++ P+Gv++d +  ++y+aDs+n+r+++
  EFC39316.1 250 LSLPAGVRYDsKRREVYIADSNNQRIRK 277
                 567***********************97 PP

  == domain 6  score: 13.6 bits;  conditional E-value: 2.6e-05
                 SSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavdsnGdiyVaDsenhrvqv 27 
                 n+P++v+++  G+++++Ds n rv++
  EFC39316.1 307 NHPNSVTLNELGEVFISDSQNYRVRK 332
                 79**********************87 PP

  == domain 7  score: 10.7 bits;  conditional E-value: 0.00022
                 SEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvqv 27 
                 yP+G+  + nG+++ aDs nh++++
  EFC39316.1 363 YPRGIISNENGEFFYADSSNHCIRK 387
                 799********************97 PP

  == domain 8  score: 29.2 bits;  conditional E-value: 2.9e-10
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n Ph+va++  +G+iy+aD+en+r+++
  EFC39316.1 417 LNTPHDVALNlATGEIYIADTENNRIRK 444
                 789***********************97 PP

  == domain 9  score: 11.1 bits;  conditional E-value: 0.00016
                 BSSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvq 26 
                 +n+P+Gv +d ++G+++ +D+en+r++
  EFC39316.1 474 LNEPSGVEIDsTSGEVFFSDTENFRIR 500
                 799**********************97 PP

  == domain 10  score: 6.1 bits;  conditional E-value: 0.0064
                 EEEEEECCCTEEEEE CS
         NHL  14 diyVaDsenhrvqvF 28 
                 +iy aDs+n+r+++F
  EFC39316.1 544 EIYFADSGNNRIRKF 558
                 57779********99 PP

  == domain 11  score: 25.2 bits;  conditional E-value: 5.7e-09
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n+P Gv++d +++++y+aD  nhr+++
  EFC39316.1 587 LNFPVGVTYDpKTNQVYIADLSNHRIRK 614
                 79************************97 PP

  == domain 12  score: 0.6 bits;  conditional E-value: 0.35
                 SSEEEEEEETTTEEEEEECCCT CS
         NHL   2 nyPhGvavdsnGdiyVaDsenh 23 
                 n PhG  + +nGd++ +Ds n+
  EFC39316.1 645 NGPHGMILQPNGDVIFSDSTNN 666
                 578888888******9997776 PP

  == domain 13  score: -3.2 bits;  conditional E-value: 5.7
                 EEEEEET CS
         NHL   5 hGvavds 11 
                 +G++v++
  EFC39316.1 759 NGLCVSN 765
                 5777754 PP

  == domain 14  score: -2.4 bits;  conditional E-value: 3
                 EEEEEETT CS
         NHL   5 hGvavdsn 12 
                 hG++v++n
  EFC39316.1 828 HGLCVSNN 835
                 9****754 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.4   0.0   0.00014      0.29      41      78 ..      68     105 ..      55     113 .. 0.86
   2 !   11.5   0.0   0.00013      0.26      37      78 ..     121     162 ..     107     168 .. 0.88
   3 ?    2.8   0.0     0.067   1.3e+02      41      78 ..     182     217 ..     174     223 .. 0.83
   4 !   12.8   0.0   5.3e-05       0.1      41      78 ..     238     275 ..     233     279 .. 0.88
   5 ?   -1.1   0.0       1.1   2.3e+03      31      78 ..     395     442 ..     374     445 .. 0.77
   6 ?   -2.1   0.0       2.3   4.7e+03      41      72 ..     462     493 ..     453     500 .. 0.79
   7 ?   -0.7   0.0      0.83   1.7e+03      53      78 ..     530     555 ..     525     561 .. 0.84
   8 !   13.9   0.0   2.3e-05     0.047      41      78 ..     575     612 ..     554     616 .. 0.86
   9 ?   -3.5   0.0       6.5   1.3e+04      41      73 ..     632     663 ..     632     671 .. 0.75
  10 ?   -2.4   0.0       2.8   5.6e+03      26      65 ..    1170    1212 ..    1166    1214 .. 0.61

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00014
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   y+++ +    ++l+ + GI +d++ + +y+ad+ ++ i
    EFC39316.1  68 YNGDGLDATSAQLNNPVGIYVDTNSREVYIADSNNHRI 105
                   7777778888999********************99998 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 0.00013
  Arylesterase  37 avvYyspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   ++  y++++ +   ++l+++ GI+id+++  i+++d+ ++ i
    EFC39316.1 121 GIAGYNGDDKSADSAQLNTPSGIVIDPNNGEIFISDSKNHRI 162
                   556689999999999**********************99988 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.067
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   y+++ ++   ++l+ +nGI  d  +k +++ad  ++ i
    EFC39316.1 182 YNGDGIEAKFAKLYLPNGI--DLYEKELFIADQNNHRI 217
                   66677777888999****8..678999*****999987 PP

  == domain 4  score: 12.8 bits;  conditional E-value: 5.3e-05
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   y+++++     +ls + G+ +d++++ +y+ad+ ++ i
    EFC39316.1 238 YNGDNILATNCKLSLPAGVRYDSKRREVYIADSNNQRI 275
                   6777777788899*******************988877 PP

  == domain 5  score: -1.1 bits;  conditional E-value: 1.1
  Arylesterase  31 lqlawtavvYyspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   l  a t+   y+++ ++   ++l+++  + ++     iy+ad  ++ i
    EFC39316.1 395 LTIAGTGTKGYNGDGIEATSAQLNTPHDVALNLATGEIYIADTENNRI 442
                   5555566666888888888899999999999999999****9988877 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 2.3
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvad 72 
                   y+++ +  v + l+ + G+ id+    ++ +d
    EFC39316.1 462 YNGDGIMAVDAWLNEPSGVEIDSTSGEVFFSD 493
                   6677777777889999******9998888776 PP

  == domain 7  score: -0.7 bits;  conditional E-value: 0.83
  Arylesterase  53 lssanGInidadkkyiyvadilresi 78 
                   l +++ I++ +    iy ad+ ++ i
    EFC39316.1 530 LATPTEIQYVPSTTEIYFADSGNNRI 555
                   67899999999999999999988877 PP

  == domain 8  score: 13.9 bits;  conditional E-value: 2.3e-05
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadilresi 78 
                   y+++++    + l+++ G+++d++   +y+ad+ ++ i
    EFC39316.1 575 YNGDNMPATRAWLNFPVGVTYDPKTNQVYIADLSNHRI 612
                   7888888888899********************99988 PP

  == domain 9  score: -3.5 bits;  conditional E-value: 6.5
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadi 73 
                   y+++++     +++ + G+ ++++  +i+ +d+
    EFC39316.1 632 YNGNNLTALSTQVNGPHGMILQPNGDVIF-SDS 663
                   77888888888899999999999888887.344 PP

  == domain 10  score: -2.4 bits;  conditional E-value: 2.8
  Arylesterase   26 llemslqlawtavvYyspsev...kvvasglssanGInidadk 65  
                    ll++++ +  + v Y+  +     ++  + ls++n +++++++
    EFC39316.1 1170 LLIITILTVLSCVFYWRKKRKlmeETRTKLLSTPNSLQYSPHQ 1212
                    5555566666777777665431113455668889999998876 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.5         9   1.8e+04      10      15 ..      12      17 ..      12      18 .. 0.83
   2 !   20.0   9.1   3.3e-07   0.00065       6      32 .]     687     712 ..     683     712 .. 0.89
   3 !   10.5  12.8    0.0003      0.59       1      30 [.     717     742 ..     713     745 .. 0.84
   4 !   12.4  14.8   7.9e-05      0.16       6      32 .]     754     779 ..     750     779 .. 0.89
   5 !   14.0  15.5   2.5e-05      0.05       1      30 [.     784     811 ..     784     814 .. 0.84
   6 !   12.2  11.5   9.3e-05      0.19       6      28 ..     823     844 ..     819     848 .. 0.80

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 9
       EGF_2 10 ghGtCv 15
                g+G+C+
  EFC39316.1 12 GQGICD 17
                799998 PP

  == domain 2  score: 20.0 bits;  conditional E-value: 3.3e-07
       EGF_2   6 eiCgghGtC.vnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +   G+C+C++g+ G++C
  EFC39316.1 687 NVCNGRGWCmE--SGKCSCQDGWIGDYC 712
                 68*******44..68************* PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.0003
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 C++   +C ghG Cv+ +  C+C+ g+ G+
  EFC39316.1 717 CEN---DCYGHGRCVSNN-TCECEYGWDGN 742
                 665...5*******9555.9*******996 PP

  == domain 4  score: 12.4 bits;  conditional E-value: 7.9e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ +G Cv+ +  C+C+sg+ G +C
  EFC39316.1 754 NNCNSNGLCVSNN-TCSCQSGWAGTDC 779
                 57*******9555.9************ PP

  == domain 5  score: 14.0 bits;  conditional E-value: 2.5e-05
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGk 30 
                 Cs   ++C+ hG+C++ +  C+C+sg+ G+
  EFC39316.1 784 CSG-ASNCSDHGSCISNN-TCHCNSGWKGN 811
                 776.478*******9555.9********96 PP

  == domain 6  score: 12.2 bits;  conditional E-value: 9.3e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyq 28 
                 ++C++hG Cv+ +  C+C+sg+ 
  EFC39316.1 823 NDCSNHGLCVSNN-TCQCSSGWN 844
                 78*******9555.9*******6 PP

>> Linker_histone  linker histone H1 and H5 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0      0.12   2.3e+02      45      69 ..      43      67 ..      29      68 .. 0.87
   2 ?    2.4   0.0       0.1   2.1e+02      47      69 ..     102     124 ..      87     125 .. 0.87
   3 ?   -0.1   0.0      0.61   1.2e+03      47      69 ..     159     181 ..     151     182 .. 0.88
   4 ?    2.6   0.0     0.088   1.8e+02      47      69 ..     272     294 ..     258     295 .. 0.88
   5 ?    1.1   0.0      0.26   5.2e+02      47      69 ..     382     404 ..     370     405 .. 0.90
   6 ?   -1.1   0.0       1.3   2.5e+03      47      66 ..     439     458 ..     436     462 .. 0.88
   7 ?    1.7   0.0      0.17   3.4e+02      39      67 ..     601     629 ..     593     633 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.12
  Linker_histone 45 llkkalkkgvekgelvqpkgkGasG 69
                      ++ ++k  ++g++v + g+G++G
      EFC39316.1 43 ATNHRIRKVFTNGTIVTIAGNGFAG 67
                    57899*****************998 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.1
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k +++g+++ + g+G++G
      EFC39316.1 102 NHRIRKILQNGKITTIAGTGIAG 124
                     7899****************998 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.61
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k +++g+++ + g+G +G
      EFC39316.1 159 NHRIRKILQNGKITTIAGTGEAG 181
                     6789*************999766 PP

  == domain 4  score: 2.6 bits;  conditional E-value: 0.088
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k +e+g++v + g+G +G
      EFC39316.1 272 NQRIRKILESGIIVTIAGTGEAG 294
                     899***************99776 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.26
  Linker_histone  47 kkalkkgvekgelvqpkgkGasG 69 
                     ++ ++k +++g++  + g+G++G
      EFC39316.1 382 NHCIRKILTNGTILTIAGTGTKG 404
                     67899***************998 PP

  == domain 6  score: -1.1 bits;  conditional E-value: 1.3
  Linker_histone  47 kkalkkgvekgelvqpkgkG 66 
                     ++ ++k +++g+++ + g+G
      EFC39316.1 439 NNRIRKILTNGTITTIAGTG 458
                     67899***********9998 PP

  == domain 7  score: 1.7 bits;  conditional E-value: 0.17
  Linker_histone  39 vskfksllkkalkkgvekgelvqpkgkGa 67 
                     +  ++ l ++ ++k +++g+++ + g+G 
      EFC39316.1 601 QVYIADLSNHRIRKILTNGTITTIAGTGK 629
                     55556778999*************99985 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   2.1   9.6e-05      0.19       4      32 .]     686     711 ..     684     711 .. 0.86
   2 ?    3.7  11.9      0.04        79       1      31 [.     717     742 ..     712     743 .. 0.89
   3 !    8.8   9.0     0.001         2       4      30 ..     754     776 ..     750     778 .. 0.89
   4 ?    5.2  10.8     0.013        26       1      31 [.     784     811 ..     779     812 .. 0.86
   5 !   12.8   7.1   5.6e-05      0.11       1      29 [.     819     844 ..     819     847 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.6e-05
                 TT.STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF   4 np.CsngGtCvdtgrggytCiCpeGytGkr 32 
                  + C+++G C+++g    +C C+ G+ G++
  EFC39316.1 686 LNvCNGRGWCMESG----KCSCQDGWIGDY 711
                 455*******9999....**********86 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.04
                 GCSTTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 CspnpCsngGtCvdtgrggytCiCpeGytGk 31 
                 C  n C ++G+Cv++     tC+C  G++G+
  EFC39316.1 717 CE-NDCYGHGRCVSNN----TCECEYGWDGN 742
                 44.77***********....*********97 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.001
                 TTSTTT-EEEEETTTEEEEEECTTEES CS
         EGF   4 npCsngGtCvdtgrggytCiCpeGytG 30 
                 n+C+ +G Cv++     tC C++G++G
  EFC39316.1 754 NNCNSNGLCVSNN----TCSCQSGWAG 776
                 88***********....********99 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.013
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs   +Cs +G C+++     tC+C +G++G+
  EFC39316.1 784 CSGaSNCSDHGSCISNN----TCHCNSGWKGN 811
                 444457*******9999....*********96 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 5.6e-05
                 GCSTT.STTT-EEEEETTTEEEEEECTTEE CS
         EGF   1 Cspnp.CsngGtCvdtgrggytCiCpeGyt 29 
                 C  ++ Csn+G Cv++     tC+C++G+ 
  EFC39316.1 819 CELTNdCSNHGLCVSNN----TCQCSSGWN 844
                 888555***********....*******97 PP

>> GTP1_OBG  GTP1/OBG
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.2   0.2     0.031        61      54     117 ..      49     112 ..      38     142 .. 0.70
   2 ?    2.3   0.2     0.059   1.2e+02      46     121 ..      98     181 ..      93     195 .. 0.67
   3 ?    0.6   0.2      0.19   3.9e+02      41     109 ..     151     216 ..     148     247 .. 0.63
   4 ?    2.2   0.1     0.059   1.2e+02      64     136 ..     231     310 ..     207     322 .. 0.58
   5 ?    0.5   0.1       0.2   3.9e+02      41     100 ..     431     488 ..     376     533 .. 0.70
   6 ?    6.4   0.1     0.003         6      46     118 ..     548     620 ..     543     671 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.2 bits;  conditional E-value: 0.031
                 GCCCTSSEEE-------BTTTB-------EEEEESTTEEEEETTTTEEEEEE-STT-EEEEE-- CS
    GTP1_OBG  54 ldlkykkkikAenGenGkgknksGkkgkdlvikvPvgtvvkdeetgevladltedgeevlvakG 117
                  ++ ++ +i    G+   g n +G ++++  ++ Pvg  v  ++++  +ad +++  + ++ +G
  EFC39316.1  49 RKVFTNGTIVTIAGNGFAGYNGDGLDATSAQLNNPVGIYVDTNSREVYIADSNNHRIRKILQNG 112
                 45555555555555555667889*****************988777778888777766666555 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.059
                 E-TT--SSGCCCTSSEEE-------BTTTB-------EEEEESTTEEEEE........TTTTEEEEEE-STT-EEEEE-----E CS
    GTP1_OBG  46 adeklntlldlkykkkikAenGenGkgknksGkkgkdlvikvPvgtvvkd........eetgevladltedgeevlvakGGkgG 121
                 ad++ + + ++ ++ ki+   G+   g n + k++++  ++ P g v+          +++++ + ++ ++g+ +++a  G+ G
  EFC39316.1  98 ADSNNHRIRKILQNGKITTIAGTGIAGYNGDDKSADSAQLNTPSGIVIDPnngeifisDSKNHRIRKILQNGKITTIAGTGEAG 181
                 4555556666666777777777777777888899999999*******9741222222244555667777777777777666666 PP

  == domain 3  score: 0.6 bits;  conditional E-value: 0.19
                 -EEEEE-TT--SSGCCCTSSEEE-------BTTTB-------EEEEESTTEEEEETTTTEEEEEE-STT CS
    GTP1_OBG  41 dvileadeklntlldlkykkkikAenGenGkgknksGkkgkdlvikvPvgtvvkdeetgevladltedg 109
                 ++++  ++++  + ++ ++ ki+   G+   g n +G ++k   + +P g  +++  ++ ++ad +++ 
  EFC39316.1 151 EIFISDSKNH-RIRKILQNGKITTIAGTGEAGYNGDGIEAKFAKLYLPNGIDLYE--KELFIADQNNHR 216
                 5555544444.444444467777777777777889999999999999*9999986..333455554444 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.059
                 -------BTTTB----..---EEEEESTTEEEEE........TTTTEEEEEE-STT-EEEEE-----EE-GGGC-C.SSCSS-- CS
    GTP1_OBG  64 AenGenGkgknksGkk..gkdlvikvPvgtvvkd........eetgevladltedgeevlvakGGkgGkGnaafks.stnrapr 136
                 A nG++G     +G +  ++++ +++P g    +        +++++ + ++ e+g  v++a  G+ G  n   ++ s+ + p+
  EFC39316.1 231 AGNGNSGY----NGDNilATNCKLSLPAGVRYDSkrrevyiaDSNNQRIRKILESGIIVTIAGTGEAGFDNILNATqSKVNHPN 310
                 44444443....333333889999999999886522222222344556777778888888888888888886655523344454 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.2
                 -EEEEE-TT--SSGCCCTSSEEE-------BTTTB-------EEEEESTTEEEEETTTTE CS
    GTP1_OBG  41 dvileadeklntlldlkykkkikAenGenGkgknksGkkgkdlvikvPvgtvvkdeetge 100
                 ++++ ad++ n + ++ ++ +i+   G+   g n +G  + d  ++ P g  + + ++ge
  EFC39316.1 431 EIYI-ADTENNRIRKILTNGTITTIAGTGDYGYNGDGIMAVDAWLNEPSGVEIDS-TSGE 488
                 4443.45555556666666777777777777777777777777777777777764.3444 PP

  == domain 6  score: 6.4 bits;  conditional E-value: 0.003
                 E-TT--SSGCCCTSSEEE-------BTTTB-------EEEEESTTEEEEETTTTEEEEEE-STT-EEEEE--- CS
    GTP1_OBG  46 adeklntlldlkykkkikAenGenGkgknksGkkgkdlvikvPvgtvvkdeetgevladltedgeevlvakGG 118
                 ad+  n + +++++ +++   G++ +g n +   ++   ++ Pvg +   ++++  +adl+++  + ++ +G 
  EFC39316.1 548 ADSGNNRIRKFTINGMMTTIAGTSTSGYNGDNMPATRAWLNFPVGVTYDPKTNQVYIADLSNHRIRKILTNGT 620
                 6777888999999999999999999999999999***********9988777777788888887777776664 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.2         9   1.8e+04       4       9 ..      13      18 ..      12      20 .. 0.70
   2 ?    0.8   7.6      0.44   8.8e+02       1      22 []     689     707 ..     689     707 .. 0.91
   3 ?    7.5   8.8    0.0033       6.6       1      22 []     721     739 ..     721     739 .. 0.90
   4 ?    9.9   7.0   0.00059       1.2       1      22 []     756     774 ..     756     774 .. 0.90
   5 ?   11.6   7.4   0.00017      0.33       1      22 []     790     808 ..     790     808 .. 0.90
   6 ?   -3.7   0.4         9   1.8e+04       4      16 ..     811     819 ..     810     820 .. 0.70
   7 ?   14.3   6.4   2.5e-05      0.05       1      22 []     825     843 ..     825     843 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 9
                T-EES. CS
        hEGF  4 gGtCid 9 
                 G+C++
  EFC39316.1 13 QGICDG 18
                589*94 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.44
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn+ G C     ++kC C  G+
  EFC39316.1 689 CNGRGWCM---ESGKCSCQDGW 707
                 99999999...888*******9 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0033
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G+C+    +++C+C  G+
  EFC39316.1 721 CYGHGRCV---SNNTCECEYGW 739
                 ********...446*****999 PP

  == domain 4  score: 9.9 bits;  conditional E-value: 0.00059
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn +G C+    +++C C +G+
  EFC39316.1 756 CNSNGLCV---SNNTCSCQSGW 774
                 9*******...446******** PP

  == domain 5  score: 11.6 bits;  conditional E-value: 0.00017
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+ +G+Ci    +++C+C++G+
  EFC39316.1 790 CSDHGSCI---SNNTCHCNSGW 808
                 999*****...446******** PP

  == domain 6  score: -3.7 bits;  conditional E-value: 9
                 T-EES..-SS.-E CS
        hEGF   4 gGtCidgvggykC 16 
                 +++C      ++C
  EFC39316.1 811 NAQCS----QFTC 819
                 67888....7788 PP

  == domain 7  score: 14.3 bits;  conditional E-value: 2.5e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+n+G C+    +++C+C +G+
  EFC39316.1 825 CSNHGLCV---SNNTCQCSSGW 843
                 ********...446******** PP

>> PPC  Bacterial pre-peptidase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.6       2.7   5.5e+03      11      45 ..      54      92 ..      51     155 .. 0.59
   2 ?    5.3   0.6     0.022        44       6      48 ..     890     932 ..     887     960 .. 0.76
   3 ?    2.0   0.0      0.23   4.5e+02       4      40 ..    1059    1096 ..    1056    1125 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 2.7
                TT-EEEEEES-TT.........SE.EEEE-TT..-SS-EE-ST CS
         PPC 11 agdsltididggti.......dld.Lylldsngtsvaaydans 45
                +g+ +ti+  +g++       d++  +l ++ g  v++   ns
  EFC39316.1 54 NGTIVTIA-GNGFAgyngdglDATsAQLNNPVGIYVDT---NS 92
                45556666.55555777776644455565555422222...11 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.022
                 EEEE-TT-EEEEEES-TT..SEEEEE-TT..-SS-EE-STT-T CS
         PPC   6 sfevpagdsltididggtidldLylldsngtsvaaydansaps 48 
                 sfe+++++ +++di +   +ldL   + + ts +++++n + +
  EFC39316.1 890 SFELNENQHVNVDIGSRIMNLDLSQDKYFITSSWTNSNNLFFT 932
                 8************966666999998888888888877776333 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.23
                  EEEEEE-TT-EEEEEES-TT...SEEEEE-TT..-SS- CS
         PPC    4 vysfevpagdsltididggti.dldLylldsngtsvaa 40  
                  +y++++p+  +l+++  ++++ dl+L++  ++ +s+  
  EFC39316.1 1059 LYQITLPSMKRLSLSCKTISGrDLNLFIGENFKPSYEM 1096
                  7**************77777669999887777666555 PP

>> SBDS  Shwachman-Bodian-Diamond syndrome (SBDS) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0       0.2   3.9e+02      64      81 ..      98     115 ..      69     121 .. 0.82
   2 ?    2.3   0.1     0.088   1.8e+02      61      81 ..     152     172 ..     144     177 .. 0.86
   3 ?   -3.4   0.0       5.5   1.1e+04      64      79 ..     268     283 ..     260     285 .. 0.76
   4 ?    2.7   0.0     0.066   1.3e+02      60      80 ..     374     394 ..     367     400 .. 0.83
   5 ?   -1.0   0.0      0.93   1.8e+03      66      81 ..     437     452 ..     417     456 .. 0.81
   6 ?   -2.0   0.0         2   3.9e+03      70      81 ..     611     622 ..     598     626 .. 0.81
   7 ?   -3.8   0.0       7.1   1.4e+04      28      51 ..    1103    1135 ..    1096    1151 .. 0.68

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.2
                 ---HHHHHHHHHHHSEEE CS
        SBDS  64 teskdeiikeILkkGeiq 81 
                  +s++  i++IL++G+i 
  EFC39316.1  98 ADSNNHRIRKILQNGKIT 115
                 55677889*******996 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.088
                 HHS---HHHHHHHHHHHSEEE CS
        SBDS  61 afgteskdeiikeILkkGeiq 81 
                 +f ++sk+  i++IL++G+i 
  EFC39316.1 152 IFISDSKNHRIRKILQNGKIT 172
                 5777889999********996 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 5.5
                 ---HHHHHHHHHHHSE CS
        SBDS  64 teskdeiikeILkkGe 79 
                  +s+++ i++IL+ G 
  EFC39316.1 268 ADSNNQRIRKILESGI 283
                 567788899***9995 PP

  == domain 4  score: 2.7 bits;  conditional E-value: 0.066
                 HHHS---HHHHHHHHHHHSEE CS
        SBDS  60 kafgteskdeiikeILkkGei 80 
                 ++f  +s++ +i++IL++G+i
  EFC39316.1 374 EFFYADSSNHCIRKILTNGTI 394
                 567778899**********98 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 0.93
                 -HHHHHHHHHHHSEEE CS
        SBDS  66 skdeiikeILkkGeiq 81 
                  +++ i++IL++G+i 
  EFC39316.1 437 TENNRIRKILTNGTIT 452
                 5667899******986 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 2
                 HHHHHHHHSEEE CS
        SBDS  70 iikeILkkGeiq 81 
                  i++IL++G+i 
  EFC39316.1 611 RIRKILTNGTIT 622
                 599******986 PP

  == domain 7  score: -3.8 bits;  conditional E-value: 7.1
                  CTT---HHHHBSSSS-EEETTTT.........E CS
        SBDS   28 egkeidLsevlqsekiFtnaskG.........e 51  
                  +++e+d ++  ++ ++F  + +G          
  EFC39316.1 1103 SNQEMDFENWKSIYQVFYIRVQGlkdsttqftI 1135
                  577888888888888888888885444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       992  (0.0553294); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.90u 0.30s 00:00:01.20 Elapsed: 00:00:00.50
# Mc/sec: 7377.92
//
Query:       EFC39317.1  [L=821]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (821 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 4765.20
//
Query:       EFC39318.1  [L=178]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       345  (0.0192426); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.33s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 1077.59
//
Query:       EFC39319.1  [L=230]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.8e-40  136.2   0.0    8.7e-40  135.6   0.0    1.3  1  UQ_con      Ubiquitin-conjugating enzyme
    0.00081   19.8  11.6     0.0012   19.3  11.6    1.2  1  DUF4171     Domain of unknown function (DUF4171)
     0.0055   17.0   0.1     0.0055   17.0   0.1    2.4  2  RWD         RWD domain
  ------ inclusion threshold ------
      0.034   13.6   8.1      0.046   13.2   8.1    1.1  1  PP1c_bdg    Phosphatase-1 catalytic subunit binding region
       0.06   13.6   9.7      0.097   12.9   9.7    1.3  1  DUF755      Domain of unknown function (DUF755)
       0.11   12.2   0.0       0.17   11.6   0.0    1.4  1  Prok-E2_B   Prokaryotic E2 family B
        0.3   10.8  13.9       0.41   10.3  13.9    1.1  1  Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
       0.53   10.4   4.7       0.72   10.0   4.7    1.2  1  DDHD        DDHD domain
        1.8    9.1  13.3        2.7    8.6  13.3    1.2  1  PAF         PCNA-associated factor histone like domain


Domain annotation for each model (and alignments):
>> UQ_con  Ubiquitin-conjugating enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  135.6   0.0   4.4e-43   8.7e-40       1     139 [.      12     153 ..      12     154 .. 0.96

  Alignments for each domain:
  == domain 1  score: 135.6 bits;  conditional E-value: 4.4e-43
                 HHHHHHHHHHHSTTTTEEEEEEETTEECEEEEEEEB.TTSTTTTEEEEEEEE--TTTTTS--EEEESST-SCTTBETTSBB-CGGGS...TTT--TTSH CS
      UQ_con   1 rlqkelkelakkkpsgisaklvddenlfewkvlikgpedtpYeggvFklelefpedYPlkpPkvkfvtkifHPnvdksGevcldiLk...eekWspalt 96 
                 r++ elk l++++p+gi a ++++++++ +++ i+g ++tpYegg F le+++p++YP++pP+v+f+tki+HPn d+ G++cld+L+   +  W+p+++
  EFC39319.1  12 RMKGELKLLKNQPPHGIAAYPKNEDRIDILEAKIQGTQGTPYEGGEFVLEITLPNNYPHHPPNVRFITKIYHPNFDSGGRICLDLLNmppKGAWKPSIN 110
                 6889*******************99**************************************************************665455****** PP

                 HHHHHHHHHHHHHS--TTS-SSHHHHHHHHHTHHHHHHHHHHH CS
      UQ_con  97 lesvllsiqsLlaepnpesplnkeaakllkkdreeykkkvkey 139
                 +++ l si  L++epn +++l +++ ++++++r+ ++k +ke+
  EFC39319.1 111 ISTLLASIKLLMDEPNGDDGLMADITEQFRNNRQLFEKIAKEW 153
                 ***************************************9986 PP

>> DUF4171  Domain of unknown function (DUF4171)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3  11.6   6.2e-07    0.0012       9      68 ..     158     215 ..     155     227 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 6.2e-07
     DUF4171   9 aitSPlatgskpskklheKpsypsvsssssSksrkrehkkklssssseskkddssssksk 68 
                 aitS + t s ++ k +e  + p+v s+ +S ++ + + +k+++sss+   ddssss   
  EFC39319.1 158 AITSFVTTDSSEQTKEEENNAKPPVESNDKSSEKEK-KVRKINDSSSS-DDDDSSSSSED 215
                 9**************************888876555.56677777773.44444444333 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.1   2.8e-06    0.0055      54      78 ..      57      81 ..      29     128 .. 0.80
   2 ?   -0.1   1.9      0.55   1.1e+03      18      55 ..     146     182 ..     136     218 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 2.8e-06
                EEEEEEEE-SSTTSS--EEEEEECC CS
                xxxxxxxxxxxxxxxxxxxxxxxxx RF
         RWD 54 slkleiklpeeYPeeaPiislsste 78
                +++lei+lp++YP+ +P +++ ++ 
  EFC39319.1 57 EFVLEITLPNNYPHHPPNVRFITKI 81
                699**************99987765 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.55
                 CCCCHT--EE--S-EEEEEEECECCCC....TT-CEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         RWD  18 fevienenysikleikikldededeedsefeekkkpsl 55 
                 fe+i+ +++++k+ i+  +++d++e+++e e+  kp++
  EFC39319.1 146 FEKIA-KEWTKKYAITSFVTTDSSEQTKEEENNAKPPV 182
                 45566.77888888888888888888877555555554 PP

>> PP1c_bdg  Phosphatase-1 catalytic subunit binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   8.1   2.3e-05     0.046      80     141 ..     159     220 ..     140     225 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 2.3e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXX CS
    PP1c_bdg  80 ftatiqtaarekpkdpsdsekdlseksdeessskaeslpespdtsseeeddwe.ssaDeaeel 141
                  t+ + t ++e++k++++ +k   e++d+ s  k++ + + +d+ss+++dd+  ss+De+e l
  EFC39319.1 159 ITSFVTTDSSEQTKEEENNAKPPVESNDKSS-EKEKKVRKINDSSSSDDDDSSsSSEDEEEGL 220
                 5778899999999997777777777666655.6666667777777776666665999999975 PP

>> DUF755  Domain of unknown function (DUF755)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   9.7   4.9e-05     0.097      73     121 ..     166     214 ..     131     217 .. 0.51

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 4.9e-05
      DUF755  73 kkssqthkkkkkksrnvssrsakkksakkrkksssSSssssssssssse 121
                 ++s qt++++++ +  v s+ +++ ++kk +k + SSss+++ ssssse
  EFC39319.1 166 DSSEQTKEEENNAKPPVESNDKSSEKEKKVRKINDSSSSDDDDSSSSSE 214
                 3344444444444444555555555555544444455555555555554 PP

>> Prok-E2_B  Prokaryotic E2 family B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   8.6e-05      0.17      34     107 ..      54     124 ..      26     156 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.6e-05
   Prok-E2_B  34 sggtvdlrlvypdsfpllppavflqdpeqlkllpHintfg.gaLCllee.eldldewdpngsvadvleqlqqvLne 107
                 +gg + l++ +p+++p  pp v+          +H n+++ g +Cl      +  +w+p  ++  +l +++ +++e
  EFC39319.1  54 EGGEFVLEITLPNNYPHHPPNVRFITKI-----YHPNFDSgGRICLDLLnMPPKGAWKPSINISTLLASIKLLMDE 124
                 89********************987655.....7888865599999433344556788888888888888777764 PP

>> Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3  13.9   0.00021      0.41      94     151 ..     165     222 ..     128     229 .. 0.56

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00021
                 --------------..------------------------------------------ CS
  Cwf_Cwc_15  94 eeeakrrkeelleeareidaddedseeeeeeeeeesdddsdsdsdddddedetaeLlr 151
                 +++++++kee  + +  ++++d++se+e++ ++ +++++sd+d++++++ede++ L  
  EFC39319.1 165 TDSSEQTKEEENNAKPPVESNDKSSEKEKKVRKINDSSSSDDDDSSSSSEDEEEGLFH 222
                 2222222223344456788888888777777777777777777777788888888764 PP

>> DDHD  DDHD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   4.7   0.00036      0.72      94     171 ..     132     208 ..     114     229 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00036
        DDHD  94 ltsigaalkqkvsglvsslsallnrslelaeeesaslaessksherasesskasqeskaaesstasssaksskaeekv 171
                 +++i+++ ++ +++l++++++ +++ ++++++ +++++e++k++e++++   +s+ ++++++++  ++++ss++++++
  EFC39319.1 132 MADITEQFRN-NRQLFEKIAKEWTKKYAITSFVTTDSSEQTKEEENNAKPPVESNDKSSEKEKKVRKINDSSSSDDDD 208
                 5566666666.5899999999999999999999999999999999999999999999998888888888777666533 PP

>> PAF  PCNA-associated factor histone like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  13.3    0.0013       2.7      59     122 ..     153     218 ..     151     229 .. 0.56

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0013
         PAF  59 WQKp..IteFfkskssk.keekeNqipddeeakagsskkskkkrksepliqendsdteekkseeeek 122
                 W K+  It+F +  ss+ ++e+eN+ + + e + +ss+k+kk rk +    ++d d+ +++se+ee+
  EFC39319.1 153 WTKKyaITSFVTTDSSEqTKEEENNAKPPVESNDKSSEKEKKVRKINDS-SSSDDDDSSSSSEDEEE 218
                 6664449****77777755677776666778766655555555554433.33333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (230 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1727  (0.0963244); expected 358.6 (0.02)
Passed bias filter:                      683  (0.0380947); expected 358.6 (0.02)
Passed Vit filter:                        97  (0.00541023); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.60u 0.36s 00:00:00.96 Elapsed: 00:00:00.51
# Mc/sec: 1369.09
//
Query:       EFC39320.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 1338.48
//
Query:       EFC39321.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       868  (0.0484132); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1178.61
//
Query:       EFC39322.1  [L=755]
Description: WD40 repeat-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.9e-32  108.9   1.4    5.9e-29   99.7   0.0    3.2  3  BING4CT      BING4CT (NUC141) domain
    1.1e-06   29.2   4.3     0.0016   19.2   0.0    4.7  5  WD40         WD domain, G-beta repeat
    0.00023   19.9   0.0    0.00059   18.6   0.0    1.5  1  MMS1_N       Mono-functional DNA-alkylating methyl methanesul
    0.00091   19.5   0.0         22    5.5   0.0    4.2  4  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> BING4CT  BING4CT (NUC141) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.4       2.2   9.8e+03      55      62 ..      50      57 ..      40      64 .. 0.64
   2 !    6.8   0.0    0.0013       5.7      10      38 ..     324     352 ..     318     355 .. 0.87
   3 !   99.7   0.0   1.3e-32   5.9e-29       2      79 .]     459     537 ..     458     537 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 2.2
     BING4CT 55 tkkqrrer 62
                +kkqr+er
  EFC39322.1 50 EKKQRKER 57
                45666665 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0013
     BING4CT  10 skieslrFvpfeDvlgvghskgissiivP 38 
                 ++i+ ++  p++ v++vgh +g  s++ P
  EFC39322.1 324 DPISCMTPNPYNAVMCVGHLNGTVSMVLP 352
                 567778889******************99 PP

  == domain 3  score: 99.7 bits;  conditional E-value: 1.3e-32
     BING4CT   2 Ylth.klpgskieslrFvpfeDvlgvghskgissiivPGsGepnfdaleanpfetkkqrrereVrsLLeKlqpelItld 79 
                 Yl h + +++++++l+F+p+eD+lgvghs+g+ss+ivPGsG++ +d+   np+ t kq ++ +Vr+LLeK+++e+I+ld
  EFC39322.1 459 YLLHkMPNHTTVSDLSFCPYEDILGVGHSRGFSSLIVPGSGSSSYDSRMPNPYFTDKQVKDFNVRTLLEKIPYEMICLD 537
                 88884455689******************************************************************98 PP

>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0         4   1.8e+04       7      16 ..     215     222 ..     211     224 .. 0.67
   2 ?    1.9   0.0      0.11   4.7e+02      12      35 ..     325     348 ..     315     349 .. 0.86
   3 !   19.2   0.0   3.6e-07    0.0016       9      38 .]     365     395 ..     357     395 .. 0.87
   4 ?    3.6   0.0     0.031   1.4e+02      10      38 .]     422     446 ..     405     446 .. 0.80
   5 ?    1.9   0.1       0.1   4.7e+02       4      25 ..     461     482 ..     459     502 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 4
                 EESSSSEEEE CS
        WD40   7 ltGHssvtsl 16 
                  +GH  ++ l
  EFC39322.1 215 VKGH--ISTL 222
                 5799..8877 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.11
                 SEEEEEEETTSSEEEEEETTSEEE CS
        WD40  12 svtslafspdgawlasGsdDgtvr 35 
                 +++++  +p++a ++ G+ +gtv 
  EFC39322.1 325 PISCMTPNPYNAVMCVGHLNGTVS 348
                 599***********99*9999995 PP

  == domain 3  score: 19.2 bits;  conditional E-value: 3.6e-07
                 SS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   9 GH.ssvtslafspdgawlasGsdDgtvriWd 38 
                  H  ++ +la++p g++++++  D +v++Wd
  EFC39322.1 365 CHqAPIKHLAVDPTGRYMVTSAADDKVKVWD 395
                 79788*************99988*******9 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.031
                 SSSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40  10 HssvtslafspdgawlasGsdDgtvriWd 38 
                 H  +ts+a+s++g   + +  ++tv iW+
  EFC39322.1 422 H--ITSMAVSQSGMVAV-SL-KHTVAIWK 446
                 4..****9999999943.56.*******5 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.1
                 EEEEESSSSEEEEEEETTSSEE CS
        WD40   4 lrtltGHssvtslafspdgawl 25 
                 l++   H+ v++l+f+p+ + l
  EFC39322.1 461 LHKMPNHTTVSDLSFCPYEDIL 482
                 677888988********99986 PP

>> MMS1_N  Mono-functional DNA-alkylating methyl methanesulfonate N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.0   1.3e-07   0.00059      42      80 ..     368     411 ..     362     444 .. 0.70

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 1.3e-07
      MMS1_N  42 qpGqylavDPkgraiavsayekvflvyslkk..keilnr....ea 80 
                  p ++lavDP+gr++++sa++++++v+ + +  +  l+     e+
  EFC39322.1 368 APIKHLAVDPTGRYMVTSAADDKVKVWDIRNtyQ-PLTTvdtlEH 411
                 6889***********************8777642.2332222222 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.6   0.0    0.0087        39      42      90 ..     199     245 ..     180     247 .. 0.84
   2 ?   -0.2   0.0      0.29   1.3e+03      40      65 ..     325     350 ..     304     360 .. 0.81
   3 !    5.5   0.0    0.0048        22      37      70 ..     366     399 ..     355     431 .. 0.86
   4 ?    3.2   0.0     0.024   1.1e+02      27      65 ..     456     494 ..     426     506 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0087
  ANAPC4_WD40  42 rsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclgWg 90 
                   +++++ +g+ L  +  +g+++ ld  + +++h+ + ++    + ++W 
   EFC39322.1 199 YKIQYSLSGRKLLLGGVKGHISTLDWRKFEMLHENHFSEP--CKAVQWL 245
                  5789999**************************9999888..7888886 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.29
  ANAPC4_WD40  40 evrsLaWkpdgklLavaysdgevrll 65 
                   ++++  +p + +++v++ +g+v+++
   EFC39322.1 325 PISCMTPNPYNAVMCVGHLNGTVSMV 350
                  5677777888999********99875 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0048
  ANAPC4_WD40  37 edsevrsLaWkpdgklLavaysdgevrlldaesg 70 
                  ++  +++La  p g+ ++ + +d +v++ d+ ++
   EFC39322.1 366 HQAPIKHLAVDPTGRYMVTSAADDKVKVWDIRNT 399
                  57889************************99875 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.024
  ANAPC4_WD40  27 qrvwtleedkedsevrsLaWkpdgklLavaysdgevrll 65 
                  ++++ l++  +  +v++L++ p + +L v++s g  +l+
   EFC39322.1 456 KEIYLLHKMPNHTTVSDLSFCPYEDILGVGHSRGFSSLI 494
                  55666677788999*****************99976665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (755 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2462  (0.137319); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                       168  (0.00937029); expected 17.9 (0.001)
Passed Fwd filter:                        52  (0.00290033); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.30u 0.37s 00:00:01.67 Elapsed: 00:00:00.58
# Mc/sec: 3898.83
//
Query:       EFC39323.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-20   74.9   2.3    1.9e-20   74.3   2.3    1.3  1  Metallophos      Calcineurin-like phosphoesterase
    1.2e-12   48.2   2.2    1.9e-12   47.6   0.1    2.2  2  Pur_ac_phosph_N  Purple acid Phosphatase, N-terminal domain
    4.5e-12   46.7   0.1    1.6e-11   44.9   0.1    2.0  1  Metallophos_C    Iron/zinc purple acid phosphatase-like prote
    0.00021   21.5   0.0    0.00081   19.6   0.0    1.9  1  Metallophos_2    Calcineurin-like phosphoesterase superfamily
  ------ inclusion threshold ------
      0.067   13.7   0.2       0.31   11.6   0.0    2.2  2  PhoD_N           PhoD-like phosphatase, N-terminal domain
       0.13   12.0   0.0       0.27   11.1   0.0    1.5  1  Soyouz_module    N-terminal region of Paramyxovirinae phospho


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.3   2.3   6.3e-24   1.9e-20       2     204 .]     140     329 ..     139     329 .. 0.70

  Alignments for each domain:
  == domain 1  score: 74.3 bits;  conditional E-value: 6.3e-24
                  EEEEEESBTBTTCCTHHHHHHHHHHHHHHH..TTESEEEEEST..SSSSSHHHHHHHHHHHHHHHH..TSEEEEEC-TTSCHHHHHHHHHHHHHHH.. CS
  Metallophos   2 rilvigDlHlalgggqlddllkllddllre..ekpdlvllaGD..lvdrgdlekellellaalvky..pipvylllGNHegfeeellnkygylgif.. 91 
                   +lv gD+        ++d ++++d + r+  ++  ++l+ GD  +v   + e++++++++   +     p++++ GNHe    + +n+  y+++f  
   EFC39323.1 140 QFLVYGDMD------IFNDGQNTIDSIMRNhmKDTQFILHIGDipYVWNHEHEYKWEKWFDMIEPItsAMPYIVCNGNHE----NASNFTSYKTRFtn 227
                  567777774......444444455555333346779*******887777766666666665555556689**********....99999999999954 PP

                  ..HHHHEHHHCEEETSEEEEEETTEEEEEEEESECEEETHHHHHHHHHHHSCHHHHCCHHHHHH...HHHHTTCSEEEEEESSESSCSSSCSCCHHHH CS
  Metallophos  92 ..sepwrsdaevfnnlplaslgsgslkvlllhGgspellvsldklgslnleleapepgdewlkd...lekrekadwvivlgHsplyrgsgylfgdeal 184
                      +  + ++  n ++++++gs   +++++  +           + + l+         w+++   +++re+++++i+ +H+p+y++++++ +++ +
   EFC39323.1 228 stVSVTTKSNTQSNLYYSFDYGSI--HFITISSE-----------HDYALQ-------TRWMEEdlaKVNREETPFIIFYSHRPMYSSNENHGSYDPI 305
                  443333333455566666666666..44444444...........222333.......67899999999*****************777777777777 PP

                  H....HHHHHTTESEEEEESSSSE CS
  Metallophos 185 e....dllkkygvdlvisGHtHvy 204
                  +    +ll+ky+vdl ++GH+H y
   EFC39323.1 306 RiavePLLRKYKVDLALFGHVHAY 329
                  77777*****************86 PP

>> Pur_ac_phosph_N  Purple acid Phosphatase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.6   0.1   6.4e-16   1.9e-12       1      94 []      23     125 ..      23     125 .. 0.94
   2 ?   -0.4   0.2      0.58   1.7e+03      35      47 ..     227     239 ..     206     271 .. 0.53

  Alignments for each domain:
  == domain 1  score: 47.6 bits;  conditional E-value: 6.4e-16
  Pur_ac_phosph_N   1 peqvhlsltedtstsmtvsWitpektkksvvrygtssda..lestaeatsstyet......tnyksgyshkatltgLepgttYyYrvgddeg.. 84 
                      p+++h++lt+  +++m+v+++t+ k+k++++ y+tss+   l+ +++++ + y++        y++  +h+  l+gL p t+ yYr+  +++  
       EFC39323.1  23 PQGIHIALTG-VESEMSVMFFTQLKSKNYQIIYSTSSNLdiLDVKVKQEVEHYKYivyqvpGMYEELTVHEFILKGLPPATKIYYRIAMKNDet 115
                      899*******.**************************998889999999999999*****999************************7776666 PP

  Pur_ac_phosph_N  85 gwSevysfkT 94 
                      ++Se++sf T
       EFC39323.1 116 TTSETFSFIT 125
                      ********76 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.58
  Pur_ac_phosph_N  35 tssdalestaeat 47 
                      +s+ +++++ + +
       EFC39323.1 227 NSTVSVTTKSNTQ 239
                      2222222222222 PP

>> Metallophos_C  Iron/zinc purple acid phosphatase-like protein C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.9   0.1   5.4e-15   1.6e-11       1      56 [.     355     407 ..     355     413 .. 0.87

  Alignments for each domain:
  == domain 1  score: 44.9 bits;  conditional E-value: 5.4e-15
  Metallophos_C   1 ApvhiviGaAGndegdafkgeppqpewsafrstdyGygrltvhNathLlwefvrss 56 
                    +++hi +G+AG   +   ++++p+pews +r+t++Gy r++v+ + +L++ef r+ 
     EFC39323.1 355 GTIHIHVGTAGFELN---QKWDPKPEWSTYRETNHGYLRIKVFGKRALSVEFLRNG 407
                    79*********7777...346899******************************93 PP

>> Metallophos_2  Calcineurin-like phosphoesterase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.0   2.7e-07   0.00081      21     148 ..     163     366 ..     148     384 .. 0.64

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 2.7e-07
  Metallophos_2  21 ealkevgvdaiihaGDl....eeeep..........evleellelapvlaVrGNnD....................................eevv 66 
                    +++k++  + i+h GD+    +              +++e + +  p +++ GN++                                    ++++
     EFC39323.1 163 NHMKDT--QFILHIGDIpyvwN---HeheykwekwfDMIEPITSAMPYIVCNGNHEnasnftsyktrftnstvsvttksntqsnlyysfdygSIHF 253
                    456666..9*******764442...222234443334555555555**********9999888888877766666666666666666665533334 PP

  Metallophos_2  67 eedvlreaaelgtdlpeeaelelagek..vlliHgdpl............gvkdalaellkeaeegsdvvvcGHtHvp.................. 130
                    +   +++   l+t+  ee+  ++++e+  + ++ ++ +              + a+++ll++  +++d++++GH H                    
     EFC39323.1 254 ITISSEHDYALQTRWMEEDLAKVNREEtpFIIFYSHRPmyssnenhgsydPIRIAVEPLLRK--YKVDLALFGHVHAYertcpiseqgvcdkkkhr 347
                    44444445555555555555555444455444444434579999999988889999999999..9999********99777766666655433333 PP

  Metallophos_2 131 .evekeggvlvvnPGsvge 148
                     + ++ +g+++++ G +g 
     EFC39323.1 348 nYFKNADGTIHIHVGTAGF 366
                    2222225777777777765 PP

>> PhoD_N  PhoD-like phosphatase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0    0.0001      0.31      58      84 ..      89     116 ..      31     123 .. 0.72
   2 ?   -1.7   0.1       1.5   4.4e+03      46      77 ..     221     247 ..     205     254 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.0001
      PhoD_N  58 tvkv.evtgLkpgqeyfYrfragsessp 84 
                 tv+   ++gL+p+++++Yr+ +++ +++
  EFC39323.1  89 TVHEfILKGLPPATKIYYRIAMKNDETT 116
                 55432689*************7775444 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 1.5
      PhoD_N  46 kgtalatseldytvkvevtgLkpgqeyfYrfr 77 
                  +t +++s++ +t k      + +++++Y f 
  EFC39323.1 221 YKTRFTNSTVSVTTKS-----NTQSNLYYSFD 247
                 4444444444444443.....44556666665 PP

>> Soyouz_module  N-terminal region of Paramyxovirinae phosphoprotein (P)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   8.9e-05      0.27      11      32 ..     148     169 ..     147     170 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 8.9e-05
  Soyouz_module  11 eLlelgldvIesiqkaqekpqk 32 
                    +++++g ++I+si+++ +k ++
     EFC39323.1 148 DIFNDGQNTIDSIMRNHMKDTQ 169
                    789**************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.56
# Mc/sec: 2240.96
//
Query:       EFC39324.1  [L=556]
Description: short chain dehydrogenase/reductase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.2e-10   39.1   0.6    4.5e-09   36.1   0.8    2.3  2  adh_short     short chain dehydrogenase
    2.3e-05   24.1   0.1    7.5e-05   22.4   0.1    1.8  1  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
    0.00012   22.0   0.0    0.00021   21.3   0.0    1.3  1  KR            KR domain
  ------ inclusion threshold ------
      0.057   13.5   0.1       0.19   11.8   0.1    1.9  1  EF1G          Elongation factor 1 gamma, conserved domain
       0.15   11.8   0.0       0.27   10.9   0.0    1.3  1  DUF3830       Protein of unknown function (DUF3830)


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.1   0.8   1.2e-12   4.5e-09       2     135 ..     199     353 ..     198     366 .. 0.77
   2 ?   -3.4   0.0       1.5   5.4e+03     161     179 ..     401     419 ..     399     421 .. 0.77

  Alignments for each domain:
  == domain 1  score: 36.1 bits;  conditional E-value: 1.2e-12
                 EEEEESTTSHHHHHHHHHHHHTT-EEEE.EESCHHHHHHHHHHHHHT.TSEEEEEE-TTTSHHHHHHHHHHHHHHH.SSESEEEE---S.......... CS
   adh_short   2 vvlvtGassGIGraiakelakeGakvvv.vdrseekleevakelkee.gakalaiqvDvtdreevealvekavkkl.gkldvLvnNAGi.......... 87 
                 v +v G+++G+G++ia++la+ Ga+ vv +  +e +++e+++++ +  +  + ++++D+++ ++++++v+  ++ +  + +vLv  +            
  EFC39324.1 199 VLMVGGCCEGVGYEIAYALAQLGARKVVlACANEHEAQEAIEKMTDIsRGVVEFMHLDLSSIQSIRQFVNFYQNVMnYECHVLVSTVLCtrqsnmgknt 297
                 55788999****************988866778889999******9988889********************999988999997666554444433344 PP

                 .........S--SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHHHCTTEEEEEEE CS
   adh_short  88 .........tgsgpfselseeewervievNltgvflltravlpamlkqssGrIvnvs 135
                          +++    +++++ +e+ +++N+ g + l+ ++ ++ lk++  r+vnv 
  EFC39324.1 298 snnnssrqlQNQFIGPRFTKDGYEKNFQLNYLGRIILIDMMSDM-LKRNHTRVVNVV 353
                 44443334333333344555556677************997665.779999999996 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 1.5
                 HHHHHHHGGGTEEEEEEEE CS
   adh_short 161 rslakelaptgirvnavaP 179
                 + +ak ++++g+++ ++ P
  EFC39324.1 401 KMFAKKYQQDGVTICCCDP 419
                 5678888899999888877 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.1   2.1e-08   7.5e-05       1     115 [.     204     322 ..     204     368 .. 0.74

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 2.1e-08
                   TTTTSHHHHHHHHHHHTT-E.EEEEESSGGH.HHHHHHHHHHTTSEE..EE--TTSHHHHHHHHHHHHHHH.SSEEEEEE-----EGCSS-GGGH-H CS
  adh_short_C2   1 GaasgIGraiAkalaeeGae.vvltdlneea.kkrveelaeelgaev..lecDVtdeeqvealveevvekf.gklDilvnnagiapklkgpfletsr 92 
                   G  +g+G++iA ala+ Ga+ vvl+ +ne + ++++e++++     v  +++D ++ ++++++v+  ++ +  + ++lv  +  +++ ++   +ts 
    EFC39324.1 204 GCCEGVGYEIAYALAQLGARkVVLACANEHEaQEAIEKMTDISRGVVefMHLDLSSIQSIRQFVNFYQNVMnYECHVLVSTVLCTRQ-SNMGKNTSN 299
                   5568***************779999999999889999998865544455****************9999997789999988877777.444455666 PP

                   HHHHHHHHHHTHHHHHHHHHHHH CS
  adh_short_C2  93 eefdraldvnlyslfllakaalp 115
                   ++  r l+ ++ +   +    ++
    EFC39324.1 300 NNSSRQLQNQFIGPRFTKDGYEK 322
                   66666666555555555444444 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.3   0.0   5.9e-08   0.00021       4      77 ..     201     272 ..     198     301 .. 0.83

  Alignments for each domain:
  == domain 1  score: 21.3 bits;  conditional E-value: 5.9e-08
                 EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHT.T-EEEE----TT-HHHHHHHHHHHHH CS
          KR   4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaeleal.gaevevvaaDvsdkdavealleeika 77 
                 ++ G++ g+G e+a  la+ gar++vl   +   ++++++ i+++++     ve++++D+s+ +++++ ++ +++
  EFC39324.1 201 MVGGCCEGVGYEIAYALAQLGARKVVLACAN---EHEAQEAIEKMTDIsRGVVEFMHLDLSSIQSIRQFVNFYQN 272
                 5667789*********************999...56777789999997445799*************99987665 PP

>> EF1G  Elongation factor 1 gamma, conserved domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   5.2e-05      0.19       1      51 [.     361     418 ..     361     425 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.2e-05
        EF1G   1 kakdplaalpkskfvldewKrkYsnedteek.......alkyfwenfdkeeyslwkve 51 
                 k+++p++ +p+s ++  ++K++Y+++d  +        ++k+f ++++++++++  ++
  EFC39324.1 361 KQQKPMKMIPNSDLNASTFKKAYTEQDYFNYsmrcnllWIKMFAKKYQQDGVTICCCD 418
                 7899*********************998744444556688999999999999887775 PP

>> DUF3830  Protein of unknown function (DUF3830)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   7.5e-05      0.27      41      88 ..     130     178 ..     124     196 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 7.5e-05
                 SSSSEEEEEEE.--SSS---S-SEESS--TTEEEEEEEEHHHHSSTTT- CS
     DUF3830  41 yagneiyvllp.efaatelpaENaTvtPipGdvvlfsfektelgnpgyg 88 
                 + g  +  +++ ++ +t    EN T+ P  G+ +++ f++++ ++p++ 
  EFC39324.1 130 WGGGKTHHNVDdNISTTSTSSENSTISPADGNHMYSMFDNVDSNDPNQS 178
                 55666666665156789999********************998888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (556 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       940  (0.052429); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 3169.91
//
Query:       EFC39325.1  [L=371]
Description: hypothetical protein NAEGRDRAFT_59275 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.5e-07   29.0   0.2    1.5e-06   28.1   0.2    1.5  1  RWP-RK          RWP-RK domain
  ------ inclusion threshold ------
       0.11   12.5   2.0       0.21   11.6   1.7    1.5  1  Pinin_SDK_memA  pinin/SDK/memA/ protein conserved region


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.1   0.2   1.7e-10   1.5e-06       1      47 [.      18      68 ..      18      69 .. 0.86

  Alignments for each domain:
  == domain 1  score: 28.1 bits;  conditional E-value: 1.7e-10
      RWP-RK  1 nltleelqqyFslplkeAAksLgvskttLKricR....elgIsRWPyRkik 47
                +ltl+el+++ +l+ ++AAk Lg s+ +L+ + +    el + RWP  k +
  EFC39325.1 18 QLTLDELKSVLHLSQEQAAKVLGTSSFKLRSLFKkhreELSMVRWPTQKAR 68
                58***********************9888776665555999*****99975 PP

>> Pinin_SDK_memA  pinin/SDK/memA/ protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   1.7   2.4e-05      0.21      57     124 ..      64     137 ..      29     142 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.4e-05
  Pinin_SDK_memA  57 krekreeleeerraeqkelraleeklelke......lmetwhenkkalanflrTktePpiyYlPwkltekteel 124
                      ++ r+++ ++++++ + + ++ee+  ++e      ++    +++ +  n   T+ eP+i YlP+ l  ++  +
      EFC39325.1  64 TQKARQQMLTNNNNNNNIIVKEEEEFPRDEndfpifKKSLIYKQQIKKGNNPFTSIEPKILYLPSPLENNQHNV 137
                     2333444455555555555455666666666777777777888888888889**************99988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       781  (0.0435607); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2310.00
//
Query:       EFC39326.1  [L=203]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
       0.02   14.5   0.5      0.025   14.1   0.5    1.2  1  DUF3053          Protein of unknown function (DUF3053)
      0.044   14.0   0.2      0.098   12.9   0.2    1.7  1  DUF1477          Protein of unknown function (DUF1477)
       0.19   12.3   4.7       0.18   12.4   0.9    2.4  2  Anti-adapt_IraP  Sigma-S stabilisation anti-adaptor protein


Domain annotation for each model (and alignments):
>> DUF3053  Protein of unknown function (DUF3053)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.5   4.2e-06     0.025     108     185 ..     105     185 ..      61     198 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 4.2e-06
     DUF3053 108 eleqqlqnakaqadkaraaLkqpddlkavy....dkayektVtqpanaltpllplaeallqqlvqvgdflqkqgnqvefegn 185
                  l q+l++  +  +++r aLk   +l + +     + y+k++t+ +++++ l ++  ++ +  ++v  ++ k++++ e++++
  EFC39326.1 105 LLLQELTDILS-DREERDALKRKVELEEGFyeycMQFYQKIITENKKKMELLENQFGEIEALSIEVSSYITKRREKLEIQDK 185
                 44444444332.2345556666666655442222699***************************************999875 PP

>> DUF1477  Protein of unknown function (DUF1477)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.2   1.6e-05     0.098      34      71 ..     125     162 ..      78     172 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.6e-05
     DUF1477  34 skrngrklfyelcisfvkklltknslaletlknlfdti 71 
                  k + ++ fye+c++f +k++t+n+ ++e l+n f  i
  EFC39326.1 125 RKVELEEGFYEYCMQFYQKIITENKKKMELLENQFGEI 162
                 45566788***********************9999766 PP

>> Anti-adapt_IraP  Sigma-S stabilisation anti-adaptor protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.9     3e-05      0.18      39      83 ..      72     115 ..      70     117 .. 0.89
   2 ?    0.4   0.2      0.16   9.8e+02      26      34 ..     162     170 ..     146     198 .. 0.56

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3e-05
  Anti-adapt_IraP  39 tlskekvqeliesvekainsalessdevlksdaeLLlkqinrlls 83 
                      +++  +v+el+++  kai++ +e+ ++ + s+++LLl++++++ls
       EFC39326.1  72 KVDAINVKELSKKAVKAIKTDNEQ-NDYTMSETSLLLQELTDILS 115
                      5666789*************9999.889999**********9985 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.16
  Anti-adapt_IraP  26 Vealellls 34 
                      +eal++ +s
       EFC39326.1 162 IEALSIEVS 170
                      455555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (203 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1701  (0.0948742); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1221.87
//
Query:       EFC39327.1  [L=112]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0067   16.1   0.3     0.0081   15.8   0.3    1.0  1  YtxC             YtxC-like family
  ------ inclusion threshold ------
      0.016   15.4   0.0      0.024   14.8   0.0    1.4  1  Bac_DNA_binding  Bacterial DNA-binding protein
       0.13   12.1   1.7        1.8    8.4   0.7    2.2  2  lci              Bacillus cereus group antimicrobial protein


Domain annotation for each model (and alignments):
>> YtxC  YtxC-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.3   1.4e-06    0.0081      93     185 ..       7     102 ..       4     105 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.4e-06
        YtxC  93 keyleeLeeivdkavdeyliekeyqeFiklLkyfveiqepkielvhvvieeng...efilldengkeitkelleelaeelsdselssedllisaLi 185
                 ++ +e+L+e  +  +++y +   y +Fik  ky  ++++pk+ +  v++++++   +f+l d + k+i+   l++ +e  ++  l+ +dl++ +L 
  EFC39327.1   7 RQVVEKLKEDKNVDWNDYPMGYRYGTFIKKSKYEKNVKNPKTGEELVCMRTKSeafSFKLEDFDSKYIELFNLKTWNEVFEKGILNRDDLILEPLF 102
                 677888888888899**************************966555554444123578999999***9888888888899************996 PP

>> Bac_DNA_binding  Bacterial DNA-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0   4.1e-06     0.024      47      75 ..      30      58 ..       6      68 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 4.1e-06
                     TEEEEEEEE--BS-B-TTT--B--B--EE CS
  Bac_DNA_binding 47 FGtfkvkerkartgrnpkTgekvkipark 75
                      Gtf  k + +++ +npkTge+     +k
       EFC39327.1 30 YGTFIKKSKYEKNVKNPKTGEELVCMRTK 58
                     69*******************87663333 PP

>> lci  Bacillus cereus group antimicrobial protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.7    0.0003       1.8      21      35 ..      31      45 ..      29      49 .. 0.90
   2 ?    2.5   0.0     0.022   1.3e+02       4      24 ..      54      74 ..      51      78 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0003
         lci 21 ttwylKgkyydnskg 35
                +t++ K+ky +n+k+
  EFC39327.1 31 GTFIKKSKYEKNVKN 45
                69***********98 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.022
         lci  4 cvkssnGvFAnsFsqdgttwy 24
                c++  +  F+ + ++++ +++
  EFC39327.1 54 CMRTKSEAFSFKLEDFDSKYI 74
                99999999*********9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (112 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       521  (0.0290591); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.53
# Mc/sec: 637.77
//
Query:       EFC39328.1  [L=314]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.066   12.5   0.0       0.12   11.6   0.0    1.4  2  Lactonase  Lactonase, 7-bladed beta-propeller


Domain annotation for each model (and alignments):
>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0      0.33   5.8e+03      88     103 ..      59      74 ..      48      79 .. 0.75
   2 ?   11.6   0.0   6.7e-06      0.12     240     319 ..     243     314 .]     216     314 .] 0.78

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 0.33
                 EEEEEE-TTSSEEEEE CS
   Lactonase  88 pchlsvdedgkllavA 103
                 +ch++v++++++l v+
  EFC39328.1  59 MCHVKVSPSHHCLCVS 74 
                 5777777777777664 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 6.7e-06
                 S-S---EEEEEE-TTSSEEEEEETSSTEEEEEEE-TTT--EEEEEEEE-SSS.--EEEE-TTSSEEEEEETTTTEEEEEE CS
   Lactonase 240 ftgknsaaeIrlspdgkflyvSnRgadsiavfavdeadgtltlveevstegkfPRdfaldpsgklllvanqksdnvtvfe 319
                 ++ k  +a + +   gk ++ Sn g   i++f+ d +      v+ +++  k+P  +++d+   ll+va+q s+++ +f+
  EFC39328.1 243 IRLK-DSAGLTVDYLGKKIFLSNTG--RIIIFDFDGD-----VVGSYKADIKVPCGLDFDKRTGLLYVADQLSNSIKIFK 314
                 3333.56888888889999999965..7999999777.....799999999***************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (314 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       536  (0.0298957); expected 358.6 (0.02)
Passed bias filter:                      424  (0.0236488); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1786.05
//
Query:       EFC39329.1  [L=998]
Description: vacuolar protein sorting 39 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-24   84.8   1.1    5.2e-24   84.8   1.1    2.3  2  Vps39_2   Vacuolar sorting protein 39 domain 2
      0.002   18.0   7.5      0.011   15.7   0.1    4.2  3  Clathrin  Region in Clathrin and VPS
     0.0066   16.7   0.8      0.049   13.9   0.1    2.8  2  DUF2175   Uncharacterized protein conserved in archaea (DUF21
  ------ inclusion threshold ------
      0.097   12.9   0.1        3.1    8.1   0.3    2.4  2  DUF2685   Protein of unknown function (DUF2685)
        4.1    7.7   6.8        1.2    9.5   1.0    3.0  3  Vps39_1   Vacuolar sorting protein 39 domain 1


Domain annotation for each model (and alignments):
>> Vps39_2  Vacuolar sorting protein 39 domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1       3.7   1.3e+04      31      60 ..     747     775 ..     742     792 .. 0.67
   2 !   84.8   1.1   1.5e-27   5.2e-24       1     107 [.     863     969 ..     863     971 .. 0.98

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.7
     Vps39_2  31 sflekalrnslekkreeqvvkklrkaekls 60 
                  +l k ++ ++++ ++e v kkl+ ++ ++
  EFC39329.1 747 GYLLKHIK-ESSRYNKEIVDKKLQTSNLNE 775
                 57778884.455666667777777666554 PP

  == domain 2  score: 84.8 bits;  conditional E-value: 1.5e-27
     Vps39_2   1 lelLskhaerldplevLdllPdelplkdlesflekalrnslekkreeqvvkklrkaeklsveeellklrskkvvvteekvCavCkkrlgesvfvvyPng 99 
                 l+lL+++a+ ++ +evL +lP++ +l++l+ fl +a++ +++++r++ + ++l + ++ +v+ + +k   +++ vt+   C+vC++ +g+ vf+++P++
  EFC39329.1 863 LSLLQRRASDINIIEVLSVLPEHSELRQLSTFLTQAIQFTHHNNRTTLIKNELARNASMQVKARHVKATTRSITVTSTTSCPVCEQPIGNAVFAIFPDQ 961
                 789************************************************************************************************ PP

     Vps39_2 100 svvHlgCa 107
                 svvH++C 
  EFC39329.1 962 SVVHYRCL 969
                 *******6 PP

>> Clathrin  Region in Clathrin and VPS
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   1.1     0.026        92      72     116 ..     551     598 ..     475     613 .. 0.58
   2 !   15.7   0.1     3e-06     0.011      43     122 ..     706     809 ..     666     819 .. 0.75
   3 ?   -2.0   0.0      0.81   2.9e+03       9      41 ..     874     906 ..     855     923 .. 0.64

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.026
                 -TTHHHHHHHT...-SSHHHHHHHHHTTXTHSSHSSXSSSSHCSCHHH CS
    Clathrin  72 dlekvaklcek...adlyeeavilykkinefkkaisllkklkdfddai 116
                 ++ek+ k+  +   ++++e+++ ++++ +++ +a+ l+++l++  +++
  EFC39329.1 551 NIEKIVKRKHEpgfEKYTEQLFKVLTDTGCWRHAALLAHNLGQSTQQV 598
                 555555555442223467777779999999999999999999888887 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 3e-06
                 HHHHHHHHHHHHT..........................T-HHHHHHTTSS---S-TTHHHHHHHT-SSHHHHHHHHHTTXTHSSHSSXSSSSHCSCHH CS
    Clathrin  43 alqtallelyaky..........................ddpqeleeflkknnnydlekvaklcekadlyeeavilykkinefkkaisllkklkdfdda 115
                  ++t++++ +++y                               l++++k+++ y++e v k+++  +l ee + l+  ++++++a+++l k  d+++a
  EFC39329.1 706 RYHTEYAISLIDYvtliypvnldkrlappagteqgdlgkF-RGYLLKHIKESSRYNKEIVDKKLQTSNLNEEKISLFHVMGKHEEALTVLVK-TDLKRA 802
                 5566666666666666666666666666666666555532.256899*****************************************9666.599999 PP

                 HHTTTTT CS
    Clathrin 116 ieyaakv 122
                  ey+ +v
  EFC39329.1 803 EEYCDTV 809
                 9998776 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.81
                 -CCCCHHHHHCTT-HHHHCHHHCCHHHCHTS-- CS
    Clathrin   9 dlsrvvklfeeaglleelleyLekvlkedsken 41 
                 ++ +v   + e++ l++l  +L ++++ ++++n
  EFC39329.1 874 NIIEVLSVLPEHSELRQLSTFLTQAIQFTHHNN 906
                 444445555556666666666666665555443 PP

>> DUF2175  Uncharacterized protein conserved in archaea (DUF2175)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1      0.95   3.4e+03      43      74 ..      51      81 ..      34      90 .. 0.73
   2 !   13.9   0.1   1.4e-05     0.049       4      42 ..     942     980 ..     940     986 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.95
     DUF2175 43 edaaaLleleevlneeivklkelervaedeev 74
                + +a L + +e+l++ + +l e+++v   e++
  EFC39329.1 51 KGKASLFSYKELLEDSVQELTEIKTVDM-EDS 81
                5577899999999999999999999965.333 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 1.4e-05
     DUF2175   4 kCyiCgkeivegekFTft.kkgvvHyeClvekarkklkes 42 
                  C +C++ i +  +F +   ++vvHy Cl ++  +k +++
  EFC39329.1 942 SCPVCEQPIGNA-VFAIFpDQSVVHYRCLISNEDEKKEKN 980
                 599***999765.566555***********9998887775 PP

>> DUF2685  Protein of unknown function (DUF2685)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.08   2.9e+02       9      35 ..     441     466 ..     437     474 .. 0.83
   2 ?    8.1   0.3   0.00086       3.1       3      26 ..     942     965 ..     940     968 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.08
     DUF2685   9 qPideadvtvdtdkGtvHaGqCyqylk 35 
                 +Pi e +   +  +G + aG  ++++ 
  EFC39329.1 441 EPIREKLT-TNFKQGKIKAGIDQNFIT 466
                 69999886.899*************95 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00086
     DUF2685   3 iCvvCKqPideadvtvdtdkGtvH 26 
                  C vC qPi +a  ++  d+  vH
  EFC39329.1 942 SCPVCEQPIGNAVFAIFPDQSVVH 965
                 69*******************999 PP

>> Vps39_1  Vacuolar sorting protein 39 domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1      0.82   2.9e+03      39      78 ..      47      86 ..      31     102 .. 0.71
   2 ?    9.5   1.0   0.00032       1.2      29      82 ..     761     814 ..     749     828 .. 0.77
   3 ?   -3.2   0.0       2.8     1e+04      28      51 ..     874     897 ..     857     932 .. 0.62

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.82
     Vps39_1 39 ekkykeLidlYygkklheeALeLlkeladedeedeedssl 78
                + k+k    l+ +k+l e++++ l+e+   d ed+++ + 
  EFC39329.1 47 SGKLKGKASLFSYKELLEDSVQELTEIKTVDMEDSNQFTT 86
                5566666778899999999999999988865555444443 PP

  == domain 2  score: 9.5 bits;  conditional E-value: 0.00032
     Vps39_1  29 lkdveeiLkkekkykeLidlYygkklheeALeLlkeladedeedeedsslkgek 82 
                  ++v + L+ ++  +e i l++  ++heeAL++l++   +  e+  d+  ++e+
  EFC39329.1 761 KEIVDKKLQTSNLNEEKISLFHVMGKHEEALTVLVKTDLKRAEEYCDTVFEEEQ 814
                 5789999***************************99776644444333333333 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.8
     Vps39_1  28 dlkdveeiLkkekkykeLidlYyg 51 
                 ++ +v  +L +++++++L  +  +
  EFC39329.1 874 NIIEVLSVLPEHSELRQLSTFLTQ 897
                 444455666666666666666544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (998 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1178  (0.0657036); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.84u 0.35s 00:00:01.19 Elapsed: 00:00:00.53
# Mc/sec: 5651.91
//
Query:       EFC39330.1  [L=156]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-08   34.1   9.8    2.2e-08   34.1   9.8    1.5  2  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0      0.82   1.5e+04      29      32 ..      60      63 ..      56      68 .. 0.59
   2 !   34.1   9.8   1.2e-12   2.2e-08       3      38 ..      84     118 ..      82     119 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 0.82
                HHCC CS
     Zn_clus 29 eCtf 32
                 C+ 
  EFC39330.1 60 ICQN 63
                5663 PP

  == domain 2  score: 34.1 bits;  conditional E-value: 1.2e-12
                 -HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus   3 CdnCrkkKvKCdakkPaCsnCkklnleCtfysessk 38 
                 C +Crk ++KCd+  P+Cs C k++++C  y+++++
  EFC39330.1  84 CLSCRKLHRKCDKLLPSCSYCSKRGYNCI-YEKPKR 118
                 *****************************.988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (156 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1338  (0.0746277); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 966.25
//
Query:       EFC39331.1  [L=468]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       857  (0.0477997); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2710.21
//
Query:       EFC39332.1  [L=1860]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.6e-20   73.6   1.6    5.7e-11   42.4   0.9    3.2  2  Myosin_TH1  Unconventional myosin tail, actin- and lipid-bind
    4.5e-12   46.1  11.8    8.6e-09   35.5   0.0    4.3  4  RUN         RUN domain
    2.1e-10   41.0   9.6    4.4e-06   27.1   0.5    4.7  4  PH          PH domain


Domain annotation for each model (and alignments):
>> Myosin_TH1  Unconventional myosin tail, actin- and lipid-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.6   0.0   3.4e-10     2e-06      61     157 ..     465     606 ..     431     638 .. 0.81
   2 !   42.4   0.9   9.5e-15   5.7e-11      47     102 ..     657     712 ..     638     755 .. 0.89

  Alignments for each domain:
  == domain 1  score: 27.6 bits;  conditional E-value: 3.4e-10
  Myosin_TH1  61 lnrssksskrilvlTdkalylldpkkvkvlkrriplseItsvsvsplqDdlvvlhlke.s..kgDlllel............................. 127
                 ++ +++ ++  lvl +++ly++d k++k  ++++ +++I ++  s ++Dd+v +  k+ +  + D+l++                              
  EFC39332.1 465 VGNKNQYKEALLVLGNRNLYIIDSKSFK-TETKVRVNDIVHIVQSGYEDDIVGIVRKKdReeMYDILFQFtetkktrgadetsitvqdeerirgksfan 562
                 567888899*******************.************************99887557545***99999888888888888888888888888888 PP

  Myosin_TH1 128 ..............dfktElvtklskaykkktnkklkvkisdti 157
                                +k+E++  +s  + ++++ +lk+ + + +
  EFC39332.1 563 scsalfkeqeneiyLKKIEFFDYISAIFLSQRGLQLKIFFVNDV 606
                 88888888888888888888888888888777778888777766 PP

  == domain 2  score: 42.4 bits;  conditional E-value: 9.5e-15
  Myosin_TH1  47 dqdekvlFssrvkKlnrssksskrilvlTdkalylldpkkvkvlkrriplseItsv 102
                  +d++vlF+    K n+++k ++r++v+T++aly++dpkk k+ krri+lseI++v
  EFC39332.1 657 FGDKQVLFAGLLGKKNKRNKYQNRTIVITNRALYVFDPKKQKSFKRRIKLSEISRV 712
                 3689**********************************999************998 PP

>> RUN  RUN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.2       1.6   9.3e+03      26      56 ..     104     134 ..      95     152 .. 0.71
   2 ?   -2.0   1.4      0.55   3.3e+03      26      26 ..    1014    1014 ..     883    1095 .. 0.59
   3 !   16.0   0.5   1.5e-06    0.0087      69     134 ..    1598    1663 ..    1511    1665 .. 0.83
   4 !   35.5   0.0   1.4e-12   8.6e-09      65     132 ..    1775    1847 ..    1720    1849 .. 0.72

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.6
         RUN  26 glkkessfwallekvakllteaesllsavqe 56 
                   ++++s+++++ +v+k  ++++  +++  +
  EFC39332.1 104 FTENKDSYTNWFNEVKKWESQKDLYVKSSPQ 134
                 5688999999999998877777766655444 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.55
         RUN   26 g 26  
                  +
  EFC39332.1 1014 N 1014
                  2 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 1.5e-06
         RUN   69 dgkfrawirlaLnekkLskwlelLvsnaellssyYerealvadpefgsillslLvglsaldfslav 134 
                  ++    +i   L e+    ++elL+++++ l++ Ye ++ v d  +++++  l++ l  ++f++++
  EFC39332.1 1598 EALSVQFIYYLLSERSFMFVVELLLTSDAYLKDCYELDSVVLDRRYRDDIYPLMSLLAMFQFTFSL 1663
                  4445569*******************************************************9876 PP

  == domain 4  score: 35.5 bits;  conditional E-value: 1.4e-12
         RUN   65 k.....rsadgkfrawirlaLnekkLskwlelLvsnaellssyYerealvadpefgsillslLvglsaldfsl 132 
                  +      + d kf  +i+ aLn  ++++++e ++++++ l +yY++ alv d++      ++++ +s+l+f+l
  EFC39332.1 1775 EavdnpLDFDFKFETFICYALNRGLMAEFFESILKDRSFLAKYYDQYALVLDKDVIGNTVKYFEIISQLPFDL 1847
                  033444788999***********************************************************98 PP

>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.5   7.4e-10   4.4e-06       3     101 ..      19     119 ..      17     121 .. 0.86
   2 ?    0.9   0.0      0.11   6.6e+02      13      53 ..     466     502 ..     459     550 .. 0.70
   3 !   14.0   0.1   9.1e-06     0.054       4      61 ..     665     721 ..     662     745 .. 0.81
   4 ?    0.7   0.1      0.13   7.6e+02      16      36 ..    1540    1571 ..    1521    1619 .. 0.63

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 7.4e-10
                 EEEEEEEETSSSSCSEEEEEEEEETTEEEEESST.......TCTTESSEEEEEESTTEEEEEEECTTSSSSTSEEEEEESTSSSTEEEEEEESSHHHHH CS
          PH   3 keGwLlkkgsgkkkswkkrwfvLkdsellyyknd.......ksekdkepkgsislsncevvevvatedpkrkfcfelriverngsrtyllqasseeerk 94 
                 +eG+L+kkg++  ++   r+++++++ l+y++ +       + +   +  g+i++ ++++v        + ++++ ++  ++++++++++ ++++++ +
  EFC39332.1  19 IEGFLKKKGKNLINRAPLRYVIVRKDGLYYFDVKkdekngqDQPDLDTCLGFINILDLQSVV-----GDESDNKLTITAEKKKKTKQFVFFTENKDSYT 112
                 89**********999999******************99997777777889**********95.....566666666655555668************** PP

                 HHHHHHH CS
          PH  95 eWikaiq 101
                 +W +  +
  EFC39332.1 113 NWFNEVK 119
                 **99776 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.11
                 SSSCSEEEEEEEEETTEEEEESSTTCTTESSEEEEEESTTE CS
          PH  13 gkkkswkkrwfvLkdsellyykndksekdkepkgsislsnc 53 
                 g+k+++k+  +vL + +l++ +++    +++  +++ ++++
  EFC39332.1 466 GNKNQYKEALLVLGNRNLYIIDSK----SFKTETKVRVNDI 502
                 45669*****************99....5555555554444 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 9.1e-06
                 EEEEEEETSSSSCSEEEEEEEEETTEEEEESSTTCTTESSEEEEEESTTEEEEEEEC....T CS
          PH   4 eGwLlkkgsgkkkswkkrwfvLkdsellyykndksekdkepkgsislsncevvevva....t 61 
                  G L kk +++  +++ r +v+++  l++++++   k+k+ k+ i ls+++ v +++     
  EFC39332.1 665 AGLLGKKNKRN--KYQNRTIVITNRALYVFDPK---KQKSFKRRIKLSEISRVYRNKkkgvL 721
                 57777888887..8*******************...***************99876555542 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.13
                  C........SEEEEEEEEETTE...EEEESST CS
          PH   16 k........swkkrwfvLkdse...llyyknd 36  
                  k        + kkr+f+L+++    l+  k++
  EFC39332.1 1540 KvlydilnhKTKKRFFYLSKDPyeiLSGLKAS 1571
                  055555556899*******8877777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1860 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2257  (0.125885); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.14u 0.37s 00:00:01.50 Elapsed: 00:00:00.58
# Mc/sec: 9614.92
//
Query:       EFC39333.1  [L=123]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-07   31.7   0.0    2.5e-07   30.9   0.0    1.4  1  ESSS           ESSS subunit of NADH:ubiquinone oxidoreductase
     0.0024   17.8   1.0     0.0027   17.6   1.0    1.1  1  FA_desaturase  Fatty acid desaturase


Domain annotation for each model (and alignments):
>> ESSS  ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.9   0.0   2.8e-11   2.5e-07      22      93 ..      21     118 ..       3     122 .. 0.68

  Alignments for each domain:
  == domain 1  score: 30.9 bits;  conditional E-value: 2.8e-11
        ESSS  22 va.........................eeeeenlyekNp.dshGfdkdpvedkenmeavfffgvsivlVlgsvfvaYlpdtsiqeWArrEAerllkrR 93 
                 +                          e+++e++y+ N    +G  + ++ + +++e+ f   + + + l  + +a++pd+s+q WA++EA r+   R
  EFC39333.1  21 AGvrsfqtniaqrggghhdehhdshhdEHHHEEPYTDNDgRLFGIAQGEQYKSQGWEKRFLPLMYGGVLLLVIGLAFKPDYSVQSWAKEEALRRRAAR 118
                 444444445555555555555555555788888887775379*****************964444444444445899**************9986555 PP

>> FA_desaturase  Fatty acid desaturase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   1.0     3e-07    0.0027      59     132 ..      40     117 ..       6     122 .. 0.67

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 3e-07
  FA_desaturase  59 sawrisH.lrHHaytngpdeDpdlaplal...srfeglfryllrlllgllvlg.wllalvlglwlrrlarrrapsksrr 132
                    +++  +H  +HH +++++  D  l+++a+    + +g+ +++l l++g ++l    la+ + +  + +a+ +a +++++
     EFC39333.1  40 EHHDSHHdEHHHEEPYTD-NDGRLFGIAQgeqYKSQGWEKRFLPLMYGGVLLLvIGLAFKPDYSVQSWAKEEALRRRAA 117
                    455566655555555555.66666666668889********99999999999966666666666666666555555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (123 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       506  (0.0282224); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.30s 00:00:00.79 Elapsed: 00:00:00.49
# Mc/sec: 751.62
//
Query:       EFC39334.1  [L=399]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-57  194.2   0.7    3.6e-57  193.6   0.7    1.3  1  MCRS_N    N-terminal region of micro-spherule protein


Domain annotation for each model (and alignments):
>> MCRS_N  N-terminal region of micro-spherule protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  193.6   0.7     2e-61   3.6e-57       1     198 [.      53     253 ..      53     254 .. 0.97

  Alignments for each domain:
  == domain 1  score: 193.6 bits;  conditional E-value: 2e-61
      MCRS_N   1 rWkptDDlaLitaveqtndleavhrgvkFsckFtlkeiqeRWyalLydptiskiavaalrnLhpevvasvqkkalfskeeeellatiksteqptlekfq 99 
                 +W+p+DD++Li++ve++++ e+++ ++kF+++Ft++ei+eRW ++Lydptis+i+ +++++L+     +  k++ +s+ee+++++++++t++    +f+
  EFC39334.1  53 KWCPHDDYLLIKGVEKGMSAEEIRGSIKFERSFTTEEITERWLSILYDPTISQITGKHMNMLQ---SVKNYKRVPWSNEENQIIFKEAETHKEVPLNFE 148
                 7*************************************************************9...3344699*****************877778*** PP

      MCRS_N 100 eLldknaavfypsrtaksLeahwqllkqyqLLpdq.....svqplqkedkvllsfsdaeeelddse.lsesedevleaeleladrkqkreirqLEnels 192
                  ++dk++++++psr++k+Leah+q+++++++++++     ++qp+q++++v ++++d++e++d+++ +se e+evl+a++ ++ ++++++i+++En++s
  EFC39334.1 149 LIYDKYRDCLHPSRCPKTLEAHYQRMRRKGIIKEHissvtETQPIQTPTAVGSTMDDEDEDYDETKtFSELEKEVLNAPIPNDLEMRAQNIQLIENKVS 247
                 ************************************99999***********************999******************************** PP

      MCRS_N 193 rwqvLv 198
                 ++++L+
  EFC39334.1 248 EKNELK 253
                 ***996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1144  (0.0638072); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2429.87
//
Query:       EFC39335.1  [L=183]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.006   16.1   0.6     0.0098   15.5   0.4    1.4  1  Tsp45I    Tsp45I type II restriction enzyme
  ------ inclusion threshold ------
      0.032   13.2   3.5      0.042   12.9   3.5    1.3  1  Pox_G5    Poxvirus G5 protein
       0.56   10.4   5.1        1.7    8.8   0.0    2.6  2  DUF4710   Domain of unknown function (DUF4710)


Domain annotation for each model (and alignments):
>> Tsp45I  Tsp45I type II restriction enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.4   1.6e-06    0.0098      83     133 ..     113     163 ..     103     174 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.6e-06
      Tsp45I  83 rnpetvnrlcgrlyelGldkiyekitepketnrqiGplfkkwvkkgvlglk 133
                 + p+ v+r+  +l   G d iy+ ++   et+rq+    ++ +++++ +++
  EFC39335.1 113 KSPKVVKRILKKLEREGKDTIYDDMSTDSETERQVERWVQDNINSDIKETR 163
                 68*********************************8888777777766554 PP

>> Pox_G5  Poxvirus G5 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   3.5     7e-06     0.042      78     149 ..      50     123 ..      21     144 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 7e-06
      Pox_G5  78 iKeslRekRrealkntikRKreelekleaaiseLdvedllyeeikedlelrikklsfylfLaesn..nlkaile 149
                 +    R+kRr  + + ++ ++++  +l+++  eLd  +++ ee ke+l+ +++  +f  f   ++   +k+il+
  EFC39335.1  50 LDVPKRSKRRWNKGTFTESQMMNSLDLAQKFRELDEFEQVQEECKENLKQKVRSKMFEEFCERKSpkVVKRILK 123
                 5556799****************************************************986554113344433 PP

>> DUF4710  Domain of unknown function (DUF4710)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.0   0.00028       1.7      34      60 ..      22      48 ..      12      52 .. 0.83
   2 ?   -0.9   4.8       0.3   1.8e+03      12      39 ..      76     104 ..      69     128 .. 0.67

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00028
     DUF4710 34 kkkkqklKKyrKnvgKalrlswrcLvl 60
                + +k+ +K +rKnv+ ++  + + +v+
  EFC39335.1 22 EERKESRKAFRKNVRNVFGQTGKAVVV 48
                5689999***********999998887 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.3
     DUF4710  12 lperYepLeed.edqkeakeekkkkkkqk 39 
                 l +++  L e  + q+e ke+ k+k ++k
  EFC39335.1  76 LAQKFRELDEFeQVQEECKENLKQKVRSK 104
                 56788888877234455566666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1915  (0.10681); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.27s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1254.48
//
Query:       EFC39336.1  [L=729]
Description: kinesin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
   7.6e-109  363.7   2.1   7.6e-109  363.7   2.1    3.1  3  Kinesin       Kinesin motor domain
    3.2e-27   95.3   0.3    3.2e-27   95.3   0.3    3.1  3  Microtub_bd   Microtubule binding
  ------ inclusion threshold ------
      0.071   12.8   0.7       0.41   10.3   0.0    2.5  3  HpaB_N        4-hydroxyphenylacetate 3-hydroxylase N terminal
       0.15   12.6   1.9        0.4   11.2   0.3    2.6  2  HisKA_3       Histidine kinase
       0.99    9.7   5.2         15    5.9   0.3    3.2  3  Pdase_M17_N2  M17 aminopeptidase N-terminal domain 2
        1.4    8.6   7.3          1    9.1   1.8    2.7  2  QRPTase_C     Quinolinate phosphoribosyl transferase, C-termi


Domain annotation for each model (and alignments):
>> Kinesin  Kinesin motor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  363.7   2.1  2.5e-112  7.6e-109       1     333 []      48     370 ..      48     370 .. 0.95
   2 ?    0.0   1.1       0.1   3.1e+02     141     207 ..     420     487 ..     385     520 .. 0.72
   3 ?   -0.7   3.2      0.17   5.2e+02       6      60 ..     579     641 ..     530     664 .. 0.70

  Alignments for each domain:
  == domain 1  score: 363.7 bits;  conditional E-value: 2.5e-112
                 EE-SSSHHHHTTTTEBCEEEECTCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHHHHHHHHHHHHHTTSEEEEEEEESTTSSHHHHHTBC.... CS
     Kinesin   1 RvRplnekekeeeeeeeveveeekkeeekkskkenkeeeekkfkFdkvfdeeatqeevyeetakplvesvleGynatifaYGqtgsGKTyTmegk.... 95 
                 R+Rp+n+ ek+++e+ +ve        e+++ + +++++ ++f+Fd++f++e+ qe++++ + kp+ve+v +Gyn+tifaYGqtgsGKT+Tm+g     
  EFC39336.1  48 RFRPMNDMEKTQSEKPIVEFG------ENQNCTIKTRRSVHNFTFDRIFNSETRQEDIFNVVGKPVVEDVCKGYNGTIFAYGQTGSGKTFTMMGAgdsi 140
                 89**************99875......55666677788899********************************************************** PP

                 .....TTTSBSHHHHHHHHHHHHHHHCTTTHEEEEEEEEEEEEEETTEEEETTSTTTTSTSSEBEEEECTTSCCEEETTS--EEESSHHHHHHHHHHHH CS
     Kinesin  96 .....eeeeeGiipraleelFesikkekeekekefsvkvsylEiYneeiyDLLeskkskkkkklkiredskkgevyvkgltevevksaeevlellekge 189
                      + e +G+ipr++++lF+ +++++e    +f v++ ++EiY+e+i DLL+++    kk+lki + + +g ++v+g +e++v+sa+e+++ll+ g+
  EFC39336.1 141 lgyseHPEFKGVIPRSIDYLFRYLESNSE---IKFAVSMCFVEIYMERIKDLLDPS----KKNLKIEKREPRG-IIVSGAREERVTSAREIYQLLKIGA 231
                 ****98899***************98665...69********************99....46799***99988.************************* PP

                 HHHTSTTSSCTSHHCCSEEEEEEEEEEEETTTTTCEEEEEEEEEEEEEEECCCHHHHSSTCHHHHHHHHHHHHHHHHHHHHHHHHHHTCCTSTSCGGGS CS
     Kinesin 190 knrkvaetklneeSSRSHavftitleqknlkeeteekvkisklnLvDLAGsErasktgaaegerlkEaaniNkSLlaLgrvisaLaekkkskhipYRdS 288
                 +nr++a+tk+neeSSRSH+++ ++++qkn++++++   k +kl LvDLAGsE+++ktga +g++l+Ea++iNkSL+aLg vi+aL++  +skh+pYRdS
  EFC39336.1 232 SNRAIAATKMNEESSRSHTILIVMVSQKNITTSET---KFGKLILVDLAGSEKVKKTGA-SGSTLEEAKQINKSLSALGMVITALTDG-NSKHVPYRDS 325
                 *****************************997665...9*******************6.7999************************.********** PP

                 HHHHHTGGGHSSSSEEEEEEEE-TBGGGHHHHHHHHHHHHHHCTT CS
     Kinesin 289 kLTrlLqdsLgGnsktlmivtvspssenleetlstlkfaerakei 333
                 kLTrlLqdsLgGns+t++++++s ss n eetlstl+f+erak+i
  EFC39336.1 326 KLTRLLQDSLGGNSRTTLVINCSFSSFNEEETLSTLRFGERAKKI 370
                 *******************************************97 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.1
                 ETTSTTTTSTSSEBEEEECTTSC.CEEETTS--EEESSHHHHH..HHHHHHHHHHTSTTSSCTSHHCCSE CS
     Kinesin 141 DLLeskkskkkkklkiredskkg.evyvkgltevevksaeevl..ellekgeknrkvaetklneeSSRSH 207
                 +LLe+++   k++++++ ++k++ + ++++++e++vk++++    + ++ +++++ ++  +l    SRS 
  EFC39336.1 420 ELLENSH--IKQEIEVVTKEKEKlKEIIEEMNEITVKQSTKTSrhRSISISSSQKLFNPRRLSMFVSRSA 487
                 4666664..3344555555554445778888888888776654114566666666666666666666665 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.17
                 SHHHHTTTTEBCEEEEC.........TCTCEEEEEEEEECTTSCEEEEESEEEETTS-HHHHHH CS
     Kinesin   6 nekekeeeeeeevevee.........ekkeeekkskkenkeeeekkfkFdkvfdeeatqeevye 60 
                 +e +ke e+e++  +ee         + +e  kkskk++++ ++++ +  +vf++++++ +v e
  EFC39336.1 579 EEINKEMEQEHIRMQEElllkqksldSLEEDLKKSKKNETKWKKETMELSEVFNKTVQS-KVRE 641
                 44333333333333333666666776666777778888888888888888888877653.3333 PP

>> Microtub_bd  Microtubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.3   0.3   1.1e-30   3.2e-27      20     149 .]      41     190 ..      24     190 .. 0.89
   2 ?   -1.9   0.3      0.97   2.9e+03      63      75 ..     423     435 ..     369     470 .. 0.61
   3 ?    1.1   1.4      0.11   3.4e+02      16      63 ..     569     636 ..     562     656 .. 0.69

  Alignments for each domain:
  == domain 1  score: 95.3 bits;  conditional E-value: 1.1e-30
                  TB-EEEEEEECCCS-T.EEEETT..T............TTTEEEE-SEEEECTTHCCCCCCCC.HHHHHHHHTT--EEEEEEES.............. CS
  Microtub_bd  20 GniRvfarvrpelesekakikfp..e.........eekkkkkefsFdrvfeseseqeevfeei.sqlvqsaldgynvcifaygqTGsGKtyTmeg... 102
                   ni v +r rp+++ ek++ + p  e         +++++ ++f+Fdr+f+se+ qe++f+ + + +v+ + +gyn +ifaygqTGsGKt+Tm+g   
   EFC39336.1  41 NNIQVVCRFRPMNDMEKTQSEKPivEfgenqnctiKTRRSVHNFTFDRIFNSETRQEDIFNVVgKPVVEDVCKGYNGTIFAYGQTGSGKTFTMMGagd 138
                  59***********9997555555441444678889999***********************99345777777***********************9** PP

                  ............ST-HCHHHHHHHHHHCCTSCCCCEEEEEEEEEEESS-EEETT CS
  Microtub_bd 103 .......eeeeagmipraveeifetiselkekgwkyeielqfveiynekvqDlL 149
                         + e +g+ipr+++ +f+ ++++   ++k+++++ fveiy e+++DlL
   EFC39336.1 139 silgyseHPEFKGVIPRSIDYLFRYLESN--SEIKFAVSMCFVEIYMERIKDLL 190
                  ***99988999******************..89********************8 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.97
                  HCCCCCCCCHHHH CS
  Microtub_bd  63 eqeevfeeisqlv 75 
                  e++++ +ei++++
   EFC39336.1 423 ENSHIKQEIEVVT 435
                  4444444444433 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.11
                  HHHCTB-EEEEEEECCCS-T.EEEETT...T....................TTTEEEE-SEEEECTTH CS
  Microtub_bd  16 qelkGniRvfarvrpelesekakikfp...e.................eekkkkkefsFdrvfesese 63 
                  +elk ++R+   +++e e+e+++++ +   +                 e+k kk++ ++  vf+++ +
   EFC39336.1 569 KELKEQVRILEEINKEMEQEHIRMQEElllKqksldsleedlkkskknETKWKKETMELSEVFNKTVQ 636
                  799999*******9999999755554444414455666677776766655666777777777776653 PP

>> HpaB_N  4-hydroxyphenylacetate 3-hydroxylase N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.56   1.7e+03     220     259 ..      37      75 ..      25      76 .. 0.84
   2 ?   10.3   0.0   0.00014      0.41     130     185 ..     160     213 ..     129     224 .. 0.86
   3 ?   -2.3   0.3      0.93   2.8e+03      64      94 ..     556     586 ..     532     635 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.56
                 ETT-TTEEEEE-------S..-TTT-TTTTT----EEEEE CS
      HpaB_N 220 pvdapGlklicresfedkleesefdyplssrfdendalvv 259
                  +d + ++++cr    + +e+++ + p+  +f+en+  ++
  EFC39336.1  37 NSDNNNIQVVCRFRPMNDMEKTQSEKPIV-EFGENQNCTI 75 
                 578899******98888788899999999.9999987765 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00014
                 HHHHHHHHHHHT--EEEEES--SS-TTS-GGGSSSTTSB-EEEEE-SSEEEEEEEE CS
      HpaB_N 130 frkyleyvqendlvlthaitdpkgdRskrpseqedpdvyvrvveetddGivVrGak 185
                 + +yle   e ++++++++++  ++R k   +    +  +++++++++Gi+V+Ga+
  EFC39336.1 160 LFRYLESNSEIKFAVSMCFVEIYMERIKDLLD--PSKKNLKIEKREPRGIIVSGAR 213
                 56899999999999999999999***999877..445679***************8 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 0.93
                 EEEEGGG----SHHHHHHHHHHHHHHHHHTT CS
      HpaB_N  64 ekvnrffhiprskeDllkkrkairelarktg 94 
                   +   f i++++++l +++++++e+ +++ 
  EFC39336.1 556 SLTADNFDIEQKNKELKEQVRILEEINKEME 586
                 4455566777777777777777777766654 PP

>> HisKA_3  Histidine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.3   0.00013       0.4      31      66 ..     374     409 ..     366     411 .. 0.84
   2 ?   -2.7   0.1         3     9e+03      31      48 ..     434     451 ..     428     459 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00013
                 TTT-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTH CS
     HisKA_3  31 lekdpekaaeqlreieelarealqevRrllhnLrpa 66 
                 ++ + e +a++l+++ e a+e ++e+R++++ Lr +
  EFC39336.1 374 AKVNRELTAKELKQMLEKAKEEVNELRDIITGLRNK 409
                 555667899*************************65 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 3
                 TTT-HHHHHHHHHHHHHH CS
     HisKA_3  31 lekdpekaaeqlreieel 48 
                 ++k++ek++e ++e++e 
  EFC39336.1 434 VTKEKEKLKEIIEEMNEI 451
                 467778888888888875 PP

>> Pdase_M17_N2  M17 aminopeptidase N-terminal domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.1   3.3e+03      44      93 ..     295     345 ..     254     357 .. 0.67
   2 ?    5.9   0.3     0.005        15      16      67 ..     416     464 ..     372     466 .. 0.88
   3 ?    4.4   0.3     0.014        43      12      70 ..     620     678 ..     610     681 .. 0.88

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.1
  Pdase_M17_N2  44 a...aevsevasvtvavlptkaSRhNcpaRpdaitklVkaavkeakedealdv 93 
                   a   ++  + + +++++l +  S h  p+R   +t+l ++ + +++ + +l++
    EFC39336.1 295 AkqiNKSLSALGMVITALTDGNSKH-VPYRDSKLTRLLQDSLGGNSRT-TLVI 345
                   3122333445556788888888888.4888888888888888887765.4444 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.005
  Pdase_M17_N2  16 taalvafleaavaeliaevaeaktykavaaevsevasvtvavlptkaSRhNc 67 
                   ++++  + +++++++i+ v ++k + +  + ++e++++tv++ +tk+SRh +
    EFC39336.1 416 KFDEELLENSHIKQEIEVVTKEKEKLK--EIIEEMNEITVKQ-STKTSRHRS 464
                   5566666788999*********99999..89999******99.89*****76 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.014
  Pdase_M17_N2  12 LkektaalvafleaavaeliaevaeaktykavaaevsevasvtvavlptkaSRhNcpaR 70 
                    k++t++l ++++++v+++++e+ +++ + +  ++v+e++ + +++l +++S +  ++R
    EFC39336.1 620 WKKETMELSEVFNKTVQSKVRESVRNQNSLSGNNKVVEMLTLEIKALTSQVSFFDVATR 678
                   56788999999*************999999999******************97666666 PP

>> QRPTase_C  Quinolinate phosphoribosyl transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.3     0.078   2.3e+02      73     103 ..     417     451 ..     380     483 .. 0.77
   2 ?    9.1   1.8   0.00033         1      81     128 ..     534     585 ..     524     591 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.078
                 HHHHHTTTSE....EEEEESSHHHHHHHHHHT-SE CS
   QRPTase_C  73 vreavdkevk....ievevesleeleevleaeadi 103
                 ++e++ ++ +    iev ++ +e+l+e++e+  +i
  EFC39336.1 417 FDEELLENSHikqeIEVVTKEKEKLKEIIEEMNEI 451
                 45444222222235888889999999999877655 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00033
                 SEEEEEESSHHHHHHHHHHT-SEEEEES-....-HHHHHHHHHHHHHHSTTS CS
   QRPTase_C  81 vkievevesleeleevleaeadiimLDnf....sveelkkaveelkeknkrv 128
                  k+eve e+ e  +++l+ +++    Dnf    + +elk+ v +l+e+nk++
  EFC39336.1 534 EKMEVEREKTESKNKALQSQVSSLTADNFdieqKNKELKEQVRILEEINKEM 585
                 359**************************55544488999999888888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (729 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3073  (0.171398); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        95  (0.00529868); expected 17.9 (0.001)
Passed Fwd filter:                        30  (0.00167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.04u 0.37s 00:00:01.41 Elapsed: 00:00:00.58
# Mc/sec: 3760.50
//
Query:       EFC39337.1  [L=1316]
Description: hypothetical protein NAEGRDRAFT_72811 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.9e-76  255.7   0.0    1.2e-75  255.0   0.0    1.3  1  ECH_2            Enoyl-CoA hydratase/isomerase
    1.5e-17   63.8   0.0    4.4e-17   62.2   0.0    1.7  2  ECH_1            Enoyl-CoA hydratase/isomerase
    4.6e-16   59.1   1.7      1e-15   58.0   1.7    1.6  1  Pepdidase_M14_N  Cytosolic carboxypeptidase N-terminal domain
    4.6e-12   46.3   0.0    1.3e-11   44.8   0.0    1.7  1  Peptidase_M14    Zinc carboxypeptidase
  ------ inclusion threshold ------
      0.032   13.3   0.0      0.052   12.6   0.0    1.3  1  AstE_AspA        Succinylglutamate desuccinylase / Aspartoacy


Domain annotation for each model (and alignments):
>> ECH_2  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  255.0   0.0   3.5e-79   1.2e-75       2     334 .]     937    1276 ..     936    1276 .. 0.94

  Alignments for each domain:
  == domain 1  score: 255.0 bits;  conditional E-value: 3.5e-79
                  EEEEE--GGGTT-B-HHHHHHHHHHHHHHCC-TT-SEEEEEESSSSECE--B--HHHHHHHHCS-THH.HHHHHHHHHHHHHHHC-SS-EEEEE-BE CS
       ECH_2    2 gvitLnrpkalNaLslemvralkealkewekddevklvvlkgagekafCAGgDvralyeaakegkkee.eeffreeYklnyliatypkpvvalmdGi 97  
                  +++++nrp++ N ++ e++r+l +++k +++++ ++l++l+g g+  ++AG D+r+l++ +++g+ e+  +++r+++kl y+ a++++p++++++G+
  EFC39337.1  937 RCLQINRPRESNRITSEVARDLLHQFKVMDTNPIINLITLSGIGNGFLSAGYDFRELQNLMDKGDYETvYSLVRDTHKLAYYAANCETPTMSVINGL 1033
                  7899*************************************************************998899************************** PP

                  EETHHHHHHTTSSEEEE-TT-EEE--GGGGT----TTHHHHHHCSST...THHHHHHHH---B-HHHHHHTTS--EE--GGGHHHHHHHHHTT.... CS
       ECH_2   98 vmGgGvGlsvhgsfrvvtertvfAmPEtaIGlfPDvGgsyfLsrlpg...elGlylalTGarlkgadalaaglathyvpseklealeeaLaelessd 191 
                  ++G G++l +++++ ++t  ++f+  + a G+fPD+G++++Lsr+++    lG++l+lTGa++k++d++++g+at +  +++ + ++e+L e+++  
  EFC39337.1 1034 MLGPGTSLGTSANYVIATPGSLFSAADSAYGYFPDCGVTMLLSRVNQkheGLGTFLGLTGAQVKSSDLVNCGIATSFGMESMSQYIAERLLEVQTG- 1129
                  ********************************************95423478****************************************9887. PP

                  ....--------......----SHHHHHHHHHHHT.-S.-TTTHHHHHH.......T..--SHHHHHHHHHHHHS-HHHHHHHHHHHHHHTTT--HH CS
       ECH_2  192 eeaveevleelaeeaeeeeeeselaekreaidrlfsad.sveeiveaLek......aeaeedewakktletlkkrsPtslkvtleqlrrgrklssla 281 
                   ++ +++ + + e++e++ ++ ++a +  +i+++fs++ sveei+++L++      +++ e++wa+++le++++ sP+slkvt+++++++++   l+
  EFC39337.1 1130 -ANQDDIHNCIVESTESDVPALSFAFELYKIKEHFSNKkSVEEIIQSLKNtitdstKTKPERDWAANILENMNQLSPLSLKVTFRAIQECDQGLGLD 1225
                  .7778888888888888888777777899******98879*********88887766667788*****************************999** PP

                  HHHHHHHHHHHHHHHHSSHHHHHHHHTTS-------SSSSGGG--HHHHHHH. CS
       ECH_2  282 evlrmElrlalrllaekDfveGvrallvdkdkkPkWkpatleevtdeavealf 334 
                  e++++++r+a+rl+++kDf +Gv+++l     +P W+++++e+v+d++v++lf
  EFC39337.1 1226 ETYQRDYRIASRLIKSKDFKQGVNSVLTGI--EPVWEFESVEKVPDSVVDSLF 1276
                  ***************************997..7*****************998 PP

>> ECH_1  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   62.2   0.0   1.2e-20   4.4e-17       9     170 ..     939    1107 ..     937    1132 .. 0.83
   2 ?   -3.1   0.0       1.1   3.9e+03     185     248 ..    1195    1259 ..    1191    1260 .. 0.77

  Alignments for each domain:
  == domain 1  score: 62.2 bits;  conditional E-value: 1.2e-20
                  EEE--CGCTTEE-HHHHHHHHHHHHHHHHSTTECEEEEEE.BTSEEEEEB-HHHHHHHHC.HHHHHHHCCHH...HHHHHHHHSSSEEEEEE-SEEE CS
       ECH_1    9 iklnrPeavNalsaelltEliqalekleddksvravvLtG.gdkaFaaGadlkemaeeek.akqallkeevl...elwtklytvpkpviaavnGaai 100 
                  +++nrP++ N ++ e+  +l++ ++ +++++ +  + L G g+++ +aG d++e+++ +   +++++ + v    +l   + +++ p+++ +nG  +
  EFC39337.1  939 LQINRPRESNRITSEVARDLLHQFKVMDTNPIINLITLSGiGNGFLSAGYDFRELQNLMDkGDYETVYSLVRdthKLAYYAANCETPTMSVINGLML 1035
                  589*************************************999999***********99875555554444400045555679************** PP

                  THHHHHHHHSSEEEEETTTEEE-GGGGGTS--CTTCHHHHHHHHHHHHHHH..HHHHT-EEEHHHHHHCTSS CS
       ECH_1  101 gGGlelalacDiviaadnasfglnelklGlipgaggtqilarkvGkskAee..illlgkkisaqealkvGlv 170 
                  g G  l+  + +via   + f+++ + +G +p+ g+t  l r   k++     + l+g +++  ++ + G+ 
  EFC39337.1 1036 GPGTSLGTSANYVIATPGSLFSAADSAYGYFPDCGVTMLLSRVNQKHEGLGtfLGLTGAQVKSSDLVNCGIA 1107
                  *********************************999999988665554433114467777777777777765 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.1
                  HHHHHHHHSCHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHCTSHHHHHHHHHHHTCSH--- CS
       ECH_1  185 elaeklaekspaalrqlkealnakle.dalaeqleaeaklfestfskddikeGlqaflEkrkpef 248 
                  +++e++++ sp++l+    a+++  +   l e  + + ++ + +++++d+k+G+++ l   +p +
  EFC39337.1 1195 NILENMNQLSPLSLKVTFRAIQECDQgLGLDETYQRDYRIASRLIKSKDFKQGVNSVLTGIEPVW 1259
                  56677777788888877777777777788889999999999999999999999988666666666 PP

>> Pepdidase_M14_N  Cytosolic carboxypeptidase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.0   1.7   2.8e-19     1e-15       1     107 [.     161     287 ..     161     288 .. 0.84

  Alignments for each domain:
  == domain 1  score: 58.0 bits;  conditional E-value: 2.8e-19
  Pepdidase_M14_N   1 issafdsGnievvsaedkeevelsirkDleksehrqWFyFrvsgar.gekltftiena..gkasypkgwkgy...kvvasydrkeWrrvd...t 85 
                      ++s+f+sGn++ + +   +e++l ++ D e++ h+qWFyF +++a+ g+k++f+i n+  ++++y++g+ ++   +  a + ++ W r     +
       EFC39337.1 161 FESRFESGNLRRAVQIYDYEYDLILKFDVETNGHTQWFYFSIQNAKrGRKYKFNIVNYlkQDSLYNHGMLPLfysTNDALTKGQGWIRSGtdvC 254
                      689************999**************************998***********766677*******866666678899******96665 PP

  Pepdidase_M14_N  86 eyd.......g....gtltiththekdtvyfAy 107
                      +y+       g     t+t+++ h++d +yfAy
       EFC39337.1 255 YYRnnikrkgGsyytLTFTFEVAHDNDVCYFAY 287
                      566666666515533677777777********9 PP

>> Peptidase_M14  Zinc carboxypeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.8   0.0   3.7e-15   1.3e-11      26     193 ..     323     463 ..     297     535 .. 0.80

  Alignments for each domain:
  == domain 1  score: 44.8 bits;  conditional E-value: 3.7e-15
                    TS-EEEEEEE-SSTT..STTST-CEEEEEE-SSTT-HHHHHHHHHHHHHHHHHTTTSHHHHHHHHHEEEEEES-STHHHHHHHHHT-TTTTST-SB CS
  Peptidase_M14  26 egRplkvlkisssat..eaeegkpvvlidggiHarEwigsalllylleqLlsaYgedeeikellddtdiyilpvlNPDGyeysstedrlwrknrsn 119
                    +g++ ++l+i+s a+  +a ++++++++++++H++E  +s +   +++ L+    +  e k l++++ + i+p+lNPDG+   ++        r+ 
     EFC39337.1 323 AGNSCDALTITSFAGdpSALKTRKGIVLTARVHPGESNSSWIIKGVIDFLTG---SSIESKVLRENFIFKIVPMLNPDGVINGNY--------RCA 407
                    6899999****9988889*********************************7...89***************************7........*** PP

                    CTTSSSBS--GGGSSSSSTTSSSSBSSTTSTTBHHSSTT.SHHHHHHH.HHHHHTTEEEEEEEEESSSEEE.ESHS CS
  Peptidase_M14 120 akessceGvDlnRnFpdlwnsegastspcsetyrgpapfsepetravl.efiqkknivlfidlhsysqvil.ypyg 193
                     +     G DlnR +  +     + +++  +t          +t+ ++ +f++++++vlf d+h+ s   + + yg
     EFC39337.1 408 LS-----GSDLNRKW--H-----NPNIKTHPT--------IFHTKKMVlQFQKEREVVLFCDFHGHSRKKNmFMYG 463
                    **.....******99..2.....223333333........34555555499999***********99876656666 PP

>> AstE_AspA  Succinylglutamate desuccinylase / Aspartoacylase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.5e-05     0.052       5     107 ..     348     451 ..     345     524 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.5e-05
                 EEEEE-SSTT-HHHHHHHHHHHHHHHCCC....ESCCEE...EEEESSHHHHHCTSSSSSTT-S-CTTTTTCCCCCSSTCHHHHHHHHHHHHHHHCHCT CS
   AstE_AspA   5 vlisAGvHGnElaGvellrqllkqleead....ilgeit...lvplaNppAiaagsRyipidredLNRaFpgrslgrsldealrateaerladalfaaa 96 
                 ++++A vH  E +  ++++ ++  l   +    +l+e+    +vp+ Np ++ +g  ++ ++ +dLNR +   + +           +++++ +++++ 
  EFC39337.1 348 IVLTARVHPGESNSSWIIKGVIDFLTGSSieskVLRENFifkIVPMLNPDGVINGNYRCALSGSDLNRKWHNPNIK----THPTIFHTKKMVLQFQKER 442
                 78999999999999999999999999888444444444344579************88888*******99876666....4455667777777777444 PP

                 CCCGCEEEEEE CS
   AstE_AspA  97 lpeadivlDLH 107
                   e+ +  D+H
  EFC39337.1 443 --EVVLFCDFH 451
                 ..677777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1316 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1076  (0.0600145); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.92u 0.30s 00:00:01.22 Elapsed: 00:00:00.48
# Mc/sec: 8215.04
//
Query:       EFC39338.1  [L=200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0012   19.0  15.0     0.0081   16.2  15.0    2.3  1  DUF3430   Protein of unknown function (DUF3430)


Domain annotation for each model (and alignments):
>> DUF3430  Protein of unknown function (DUF3430)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2  15.0   4.5e-07    0.0081       5     208 ..       6     195 ..       3     198 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 4.5e-07
     DUF3430   5 fslilllllllnflinsqyinfipyqsekCsgegsssgigysieideCitndnqnnyvfsvftdssdgeiiktnyyedqnCegkpistftfeigsCvst 103
                 f+l+  ++++++ +++ +y+++  y+s +C    +s+ +   i  + C+++   n+    + t++ +  ++++ +++  +C    ++++ f+ g Cv+ 
  EFC39338.1   6 FFLFAAIFVVISGIAQAKYLQIYHYNSRNCL---ESNYVKVDIFREGCFSFE--NYVESQYATCNGSYGYLEIMKNH-IEC---GKDPIVFKLGVCVN- 94 
                 55666677777777*****************...3356777887888*****..66667778888888888888888.***...556677********. PP

     DUF3430 104 pefvnnasnsssyysykvsttdepeiptnsvvtsfyngseCsndsnflyieyftnntcine.sdntysstyyCns..tnqpytqycssknCnnkpi... 196
                          ++   sy v++ d  +  ++ + +  yn+  C+    + +++    + c ++   +  +  y+C    t  ++ +y ss++C+       
  EFC39338.1  95 -------IEDDIVRSYRVTCGD-FVSKEKMFWEMAYNDRRCEKF--VRSATGHVIGKCDATaDFGVGAKVYTCERddTRVQVLTYKSSTQCIGGIRtnq 183
                 .......3344557999***99.888899999999999788876..77777777787766644555667777777555556777777777776555555 PP

     DUF3430 197 ..elsCssennfsn 208
                   +++C+  n f+n
  EFC39338.1 184 twTTECD--NRFQN 195
                 5444664..44444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.31s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1159.12
//
Query:       EFC39339.1  [L=104]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-15   56.3   0.1    3.1e-15   56.1   0.1    1.1  1  Cyt-b5    Cytochrome b5-like Heme/Steroid binding domain


Domain annotation for each model (and alignments):
>> Cyt-b5  Cytochrome b5-like Heme/Steroid binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.1   0.1   1.7e-19   3.1e-15       2      72 ..       7      77 ..       6      79 .. 0.90

  Alignments for each domain:
  == domain 1  score: 56.1 bits;  conditional E-value: 1.7e-19
                HHHHTTTE.CTTEEEEEETTEEEECTTTCCCSTTCSHHHHTTTTSBBHHHHHHTTGGCHHHHHHHHGGEEEE CS
      Cyt-b5  2 leelskhn.gkndlwvairgkVYDvskflskhpGgesailkyaGkDateafksvvhsekdaekllkkylvGk 72
                l+e+++h  +++d w++i gkV  +  + ++hpGge++il+ aGkD t+af++  h +++ +  ++ky vG+
  EFC39339.1  7 LSEVEEHGpNHQDPWIIISGKVVAFGTYKDEHPGGEDVILEWAGKDGTKAFNDAGHGSSA-KSDMQKYIVGE 77
                589****96666******************************************998885.555599****8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (104 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       303  (0.0169); expected 358.6 (0.02)
Passed bias filter:                      245  (0.013665); expected 358.6 (0.02)
Passed Vit filter:                        10  (0.000557756); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.54
# Mc/sec: 581.97
//
Query:       EFC39340.1  [L=166]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-38  131.6   0.0    2.9e-38  131.4   0.0    1.0  1  LMWPc     Low molecular weight phosphotyrosine protein phosph


Domain annotation for each model (and alignments):
>> LMWPc  Low molecular weight phosphotyrosine protein phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  131.4   0.0   1.6e-42   2.9e-38       1     141 [.      11     158 ..      11     159 .. 0.96

  Alignments for each domain:
  == domain 1  score: 131.4 bits;  conditional E-value: 1.6e-42
                 EEEEESSSSSHHHHHHHHHHHHHHHTT-CCCEEEEEEESTST.TT-B--HHHHHHHHHTT..S--TT-BB-BS-HHHHHHSSEEEESSHHHHHHHHHHC CS
       LMWPc   1 vlfvClgNicRSpmAealfrkelekagleekvevdSaGtgal.vgkradpravevlkekg..islsghvarqlskeelaelDlilamdeenkrelesla 96 
                 v+fvClgNicRSpmAe ++ ++++++ ++ ++ vdS+Gt ++ vg++ d r+++++k+    +++++++arq+ +++++++D+il+mde+n+r+++s+ 
  EFC39340.1  11 VCFVCLGNICRSPMAEIVMLALIKEKKAKVDFIVDSCGTASYhVGEEHDDRTLSTCKKYYpwLNTDDMRARQICQDDFEDFDYILVMDESNLRNVNSIR 109
                 89*******************************************************975338999********************************9 PP

                 CT.TGGGGEEEGGGG...SSTSS---HTTSSHHHHHHHHHHHHHHHHHH CS
       LMWPc  97 pe.kekakvkllgey...teqldieDPyygeieafeevldeieeavkkl 141
                  +   kakv+llg y   +++ ++eDPyyg++++fe ++++i+++++++
  EFC39340.1 110 KNkSGKAKVQLLGCYdpeKKNSIVEDPYYGGMSGFESIFKQIKRSLENF 158
                 997789***********999**************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       777  (0.0433376); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 965.07
//
Query:       EFC39341.1  [L=394]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00095   19.1   0.0     0.0054   16.7   0.0    2.2  2  R3H       R3H domain
  ------ inclusion threshold ------
        2.7    9.1   9.0        2.5    9.2   0.1    3.1  3  MRI       Modulator of retrovirus infection


Domain annotation for each model (and alignments):
>> R3H  R3H domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0      0.26   2.4e+03      26      54 ..      63      91 ..      62      92 .. 0.89
   2 !   16.7   0.0     6e-07    0.0054       5      58 ..     206     261 ..     203     263 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.26
                --SHHHHHHHHHHHHSSEEEEEE--SS-S CS
         R3H 26 mssyeRriiHelaeaygleseSvGeepkR 54
                m+ + R +  ++a a  les+ +++ +kR
  EFC39341.1 63 MNEQSRAFTTRIAPAVVLESKKKDKSDKR 91
                88899999999999999999999999888 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 6e-07
                 HHHHHHHHHHH-S..--EEE-----SHHHHHHHHHHHHSSEEEEEE--SS-SEEEE CS
         R3H   5 rvekklaefvkdt..grslefppmssyeRriiHelaeaygleseSvGeepkRrvvv 58 
                 + e ++ +++ ++  + ++ fpp  + +R + H++ ++y + s+ v+ ep Rrv v
  EFC39341.1 206 QWEYIMDKLLLSDedEAQFIFPPGKKKLRHLEHNITDYYRILSRGVDPEPLRRVAV 261
                 55666666665542257************************************977 PP

>> MRI  Modulator of retrovirus infection
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.4      0.21   1.9e+03      39      59 ..      16      41 ..       2      55 .. 0.48
   2 ?    9.2   0.1   0.00028       2.5       1      65 [.      59     126 ..      59     150 .. 0.77
   3 ?    3.5   0.5     0.017   1.5e+02      26      62 ..     349     382 ..     334     390 .. 0.50

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.21
         MRI 39 pelspacsespssss.....gsrsee 59
                +   p++++s ++ss      s+se+
  EFC39341.1 16 DSVQPTSTNSTTTSSslnhdLSSSED 41
                44455555555555422222222222 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00028
         MRI   1 TvYcmnE...aElVDvALgiLiEarkqekpleqlalagadkpelspacsespssssgsrseeedsgkd 65 
                 T Y+mnE   a    +A ++++E++k++k+ ++     a k +  p   +s +  ++ +  e+d+g +
  EFC39341.1  59 TTYFMNEqsrAFTTRIAPAVVLESKKKDKSDKRDFAREAKKMQSKPINENSKKIIKAPSLKEDDHGLE 126
                 789**99555567899***************************9999888777666555555555544 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.017
         MRI  26 kpleqlalagadkpelspacsespssssgsrseeeds 62 
                 k+  q+ l+g  ++ ++ + s  ps+s   +see+ +
  EFC39341.1 349 KAKGQPVLTGQTEAATTEPISPKPSTS---NSEEKPQ 382
                 333444444444444444434444444...5555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1631  (0.0909699); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 2209.37
//
Query:       EFC39342.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-07   31.8   2.9    7.3e-07   29.7   0.1    3.2  3  PH               PH domain
     0.0014   18.9   0.3     0.0063   16.8   0.3    2.2  1  PH_8             Pleckstrin homology domain
     0.0033   17.4  13.0     0.0033   17.4  13.0    2.8  3  CENP-F_leu_zip   Leucine-rich repeats of kinetochore protein 
  ------ inclusion threshold ------
      0.014   15.2   4.8       0.03   14.1   1.2    2.8  3  FAM209           FAM209 family
      0.021   14.9   6.0       0.69   10.0   0.8    2.3  2  Baculo_PEP_C     Baculovirus polyhedron envelope protein, PEP
        0.1   12.8   0.6        0.1   12.8   0.6    2.9  3  DASH_Dad1        DASH complex subunit Dad1
       0.23   11.5  15.9        2.9    8.0   0.8    2.9  2  DUF1664          Protein of unknown function (DUF1664)
       0.43   11.1  27.2       0.16   12.5  13.0    2.6  2  APG6_N           Apg6 coiled-coil region
       0.85   10.1   0.1       0.85   10.1   0.1    3.8  4  PH_11            Pleckstrin homology domain
        2.3    8.4  19.4       0.04   14.0   4.1    4.1  4  bZIP_1           bZIP transcription factor
        6.1    5.6  29.1         12    4.7  29.1    1.4  1  DUF812           Protein of unknown function (DUF812)
        7.5    5.3  24.5        1.6    7.5  13.5    2.3  2  Spc7             Spc7 kinetochore protein
        7.8    7.0  31.6       0.17   12.3  13.5    4.4  5  ZapB             Cell division protein ZapB


Domain annotation for each model (and alignments):
>> PH  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.1   5.3e-10   7.3e-07       2     104 ..      26     114 ..      25     115 .. 0.87
   2 ?   -2.0   0.0       3.7     5e+03      61      80 ..     140     159 ..     125     174 .. 0.67
   3 ?   -2.3   0.0       4.6   6.3e+03      43      56 ..     292     305 ..     280     347 .. 0.63

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 5.3e-10
                 EEEEEEEEETSSSSCSEEEEEEEEETTEEEEESSTTCTTESSEEEEEESTTEEEEEEECTTSSSSTSEEEEEESTSSSTEEEEEEESSHHHHHHHHHHH CS
          PH   2 vkeGwLlkkgsgkkkswkkrwfvLkdsellyykndksekdkepkgsislsncevvevvatedpkrkfcfelriverngsrtyllqasseeerkeWikai 100
                 +k G+L+k+g++ k ++kkr+fvL +      kn        p g+i l++       a+ ++   + f lr       +++ll+a+s+ee+++W++ai
  EFC39342.1  26 IKTGILVKRGQKYK-TFKKRYFVLVS-----DKN----DLDHPLGIIYLKSNAFLNKSAEISESVGYGFTLRSG----AKRFLLAADSPEEKTAWLRAI 110
                 688***********.**********2.....244....599999999999999998764559999999999766....79******************* PP

                 HHHH CS
          PH 101 qsai 104
                  +++
  EFC39342.1 111 DKVM 114
                 9986 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 3.7
                 TTSSSSTSEEEEEESTSSST CS
          PH  61 tedpkrkfcfelriverngs 80 
                 +++ + +++f+l  +e++g+
  EFC39342.1 140 SPTNQPENMFKLDSSENSGP 159
                 56777888888877776664 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 4.6
                 SEEEEEESTTEEEE CS
          PH  43 epkgsislsncevv 56 
                   k+ i+l+n++ +
  EFC39342.1 292 MEKMYIELENITGK 305
                 55777777777754 PP

>> PH_8  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.3   4.6e-06    0.0063       1      88 [.      29     113 ..      29     114 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 4.6e-06
        PH_8   1 gillkkrrkklqgyakRfFvLdlksstlsYyrddnssalrgkiplslaiisaneekreiiidsGaevWeLkasnekdfqeWvealeka 88 
                 gil+k+  +k + ++kR+FvL   + +l+         l+ +  l++++   ++    +++ sGa+ + L a++ ++ ++W +a++k+
  EFC39342.1  29 GILVKRG-QKYKTFKKRYFVLVSDKNDLDHPL--GIIYLKSNAFLNKSAEISESVGYGFTLRSGAKRFLLAADSPEEKTAWLRAIDKV 113
                 6777765.56799********88888888755..335788888888887667777899***************************986 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       2.8   3.8e+03      76      94 ..     114     132 ..     110     135 .. 0.61
   2 ?    4.5   2.8     0.024        33      50      92 ..     171     213 ..     153     235 .. 0.83
   3 !   17.4  13.0   2.4e-06    0.0033      52     133 ..     283     364 ..     273     371 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.8
  CENP-F_leu_zip  76 valrsekeeLekelqkkqe 94 
                      +l+  ke+L+++    ++
      EFC39342.1 114 MTLSASKEKLAQQATARKR 132
                     4566667777766655555 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.024
  CENP-F_leu_zip  50 skaevetlkeeieelaeelreleldLvalrsekeeLekelqkk 92 
                     +k+++  l+++++e    l+++ +++v+l s   +L++el+ +
      EFC39342.1 171 EKEKIDRLQKQKDESLMILQQIDSNFVKLLSSISNLKRELESS 213
                     5888889999999999999999999999999999999999876 PP

  == domain 3  score: 17.4 bits;  conditional E-value: 2.4e-06
  CENP-F_leu_zip  52 aevetlkeeieelaeelreleldLvalrsekeeLekelqkkqervseLeslnsslenlleekEqekvqmkeesk...aaveeLqt 133
                     + +++lk+ +e++  el++++ +++++++++e+L   +++   +++e e+ n++l++ ++e+E e+ ++  + k   ++v++L+t
      EFC39342.1 283 ERLKGLKSTMEKMYIELENITGKVKNVQQDQEDL---IKQTETQIQEFEQENEDLRKRIQELETENEELGHHKKlliKEVKKLRT 364
                     56789*****************************...6677889********************987776666611234444444 PP

>> FAM209  FAM209 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   1.2   2.2e-05      0.03      61     121 ..     152     213 ..     147     233 .. 0.78
   2 ?   -1.2   0.1       1.1   1.6e+03      71      92 ..     224     245 ..     211     260 .. 0.61
   3 ?    1.0   0.1      0.24   3.2e+02     100     120 ..     274     294 ..     232     322 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.2e-05
      FAM209  61 ekskeqtppglrgcsfrsplkKkq.kaspskdyafntltqlemdLvkfvskvrnLKlamatg 121
                 + s+++ p+++++++++s  k k  +   +kd  +  l+q++ + vk++s + nLK  + ++
  EFC39342.1 152 DSSENSGPKNMENSTVNSFEKEKIdRLQKQKDESLMILQQIDSNFVKLLSSISNLKRELESS 213
                 456677788888888888877665167889**************************877554 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.1
      FAM209  71 lrgcsfrsplkKkqkaspskdy 92 
                 ++ +++ ++ +Kk+ +s + d+
  EFC39342.1 224 TKEVTSTPSSRKKKATSSDDDF 245
                 3444445556666666665554 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.24
      FAM209 100 lemdLvkfvskvrnLKlamat 120
                    dL++ v +++ LK +m  
  EFC39342.1 274 TVADLMNPVERLKGLKSTMEK 294
                 557999999999999999965 PP

>> Baculo_PEP_C  Baculovirus polyhedron envelope protein, PEP, C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.4    0.0032       4.5      74     110 ..     173     212 ..     157     233 .. 0.79
   2 ?   10.0   0.8    0.0005      0.69      16      80 ..     276     342 ..     271     354 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0032
  Baculo_PEP_C  74 dalnalq...dtlrneLtnlnsiltnLlssvtNinstLnn 110
                   +++ +lq   d+    L+ ++s+   Llss+ N++  L++
    EFC39342.1 173 EKIDRLQkqkDESLMILQQIDSNFVKLLSSISNLKRELES 212
                   456677766677778899****************999865 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.0005
  Baculo_PEP_C  16 ldLtnvLnairlqnvqilaqlatlldaietqLnalsedlksllaeldtrldtlltn...Ltdalnalq 80 
                    dL n ++ ++ +++++  ++   l++i ++++++++d ++l+++ +t+++++ ++   L + +++l+
    EFC39342.1 276 ADLMNPVERLKGLKSTM-EKMYIELENITGKVKNVQQDQEDLIKQTETQIQEFEQEnedLRKRIQELE 342
                   57888888888888888.88888999999999999999999999999977776654111555555554 PP

>> DASH_Dad1  DASH complex subunit Dad1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       1.7   2.3e+03      26      41 ..      69      84 ..      63      85 .. 0.80
   2 ?   12.8   0.6   7.4e-05       0.1       8      35 ..     187     214 ..     179     218 .. 0.90
   3 ?   -3.0   0.8       6.3   8.7e+03       2      11 ..     327     336 ..     310     344 .. 0.52

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 1.7
   DASH_Dad1 26 aLNRsLEeviavgkeF 41
                 LN+s E + +vg  F
  EFC39342.1 69 FLNKSAEISESVGYGF 84
                5999999999999888 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 7.4e-05
   DASH_Dad1   8 rliqeIaesmeevlnnlnaLNRsLEevi 35 
                 +++q+I +++ ++l+++  L R+LE+++
  EFC39342.1 187 MILQQIDSNFVKLLSSISNLKRELESST 214
                 689**********************985 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 6.3
   DASH_Dad1   2 FerqRdrliq 11 
                 Fe++ + l +
  EFC39342.1 327 FEQENEDLRK 336
                 3333333333 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   0.8    0.0021       2.9      66     105 ..     173     212 ..     164     226 .. 0.91
   2 ?    6.5   8.4    0.0059       8.1      37      98 ..     307     368 ..     283     374 .] 0.50

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0021
     DUF1664  66 sridrvdkkldeqkeiskeikeevtevredlseigedves 105
                 ++idr++k+ de+  i ++i+++  ++ + +s++++++es
  EFC39342.1 173 EKIDRLQKQKDESLMILQQIDSNFVKLLSSISNLKRELES 212
                 79**********************************9986 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0059
     DUF1664  37 rslsdavesvskqleqvseslaatkrhLssridrvdkkldeqkeiskeikeevtevredlse 98 
                 ++ ++  e++ kq e+  ++ ++  ++L +ri++++++ +e  + +k + +ev+++r ++s+
  EFC39342.1 307 KNVQQDQEDLIKQTETQIQEFEQENEDLRKRIQELETENEELGHHKKLLIKEVKKLRTETSQ 368
                 33334444444444444455555555555555555555555555555555555555555554 PP

>> APG6_N  Apg6 coiled-coil region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   6.0     0.053        74      44     100 ..     159     219 ..     120     246 .. 0.78
   2 ?   12.5  13.0   0.00011      0.16      47     117 ..     297     371 ..     274     374 .] 0.53

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.053
      APG6_N  44 k...qdeeleeleee.leklekeeeelleeLkelekereeleaelaaleeelealeeeeer 100
                     +++ +++ e+e +++l+k+++e l  L++++++  +l + +++l++ele    e  +
  EFC39342.1 159 PknmENSTVNSFEKEkIDRLQKQKDESLMILQQIDSNFVKLLSSISNLKRELESSTLETVE 219
                 0444567777777777999*******************************99987766555 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 0.00011
      APG6_N  47 eeleeleeeleklekeeeelle....eLkelekereeleaelaaleeelealeeeeerfwreynelqlellelee 117
                  ele++  +++++++++e+l++    +++e e+e+e+l++ +++le e e+l + ++  ++e ++l++e ++ + 
  EFC39342.1 297 IELENITGKVKNVQQDQEDLIKqtetQIQEFEQENEDLRKRIQELETENEELGHHKKLLIKEVKKLRTETSQPQT 371
                 344444444444444444444311114556666666666666666666666666666666666666666555554 PP

>> PH_11  Pleckstrin homology domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.2      0.29     4e+02       5      23 ..      31      51 ..      27      57 .. 0.67
   2 ?   10.1   0.1   0.00062      0.85      63     103 ..      71     111 ..      38     113 .. 0.66
   3 ?   -0.8   0.5       1.4     2e+03      55      81 ..     167     193 ..     133     242 .. 0.68
   4 ?    0.3   0.3      0.68   9.4e+02      66      93 ..     306     333 ..     287     347 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.29
       PH_11  5 lkkkgsk..aWkrrwfavlkd 23
                l k+g+k  + k+r+f++  d
  EFC39342.1 31 LVKRGQKykTFKKRYFVLVSD 51
                445555555*******65554 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00062
       PH_11  63 idsirssksddllleistetkifflkgdsneeteeWvealk 103
                  +s++ s+s    +++  ++k+f l++ds ee+ +W++a+ 
  EFC39342.1  71 NKSAEISESVGYGFTLRSGAKRFLLAADSPEEKTAWLRAID 111
                 3334445555667889999*******************996 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 1.4
       PH_11  55 lisaalfkidsirssksddllleiste 81 
                 + s++  kid+ + +k ++l++ ++++
  EFC39342.1 167 VNSFEKEKIDRLQKQKDESLMILQQID 193
                 334444455555555555555544444 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.68
       PH_11  66 irssksddllleistetkifflkgdsne 93 
                 +++ ++d+++l+++tet+i  ++ ++++
  EFC39342.1 306 VKNVQQDQEDLIKQTETQIQEFEQENED 333
                 4567889999999999999777776665 PP

>> bZIP_1  bZIP transcription factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.5       1.8   2.5e+03      38      56 ..     192     210 ..     172     216 .. 0.63
   2 ?    3.2   0.3      0.07        96      33      61 ..     283     311 ..     280     314 .. 0.87
   3 ?   14.0   4.1   2.9e-05      0.04      28      59 ..     317     348 ..     311     353 .. 0.89
   4 ?   11.1   4.9   0.00023      0.32      26      62 ..     329     365 ..     328     368 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.8
                 HHHHHHHHHHHHHHHHHHH CS
      bZIP_1  38 LekeNksLkseleelkkev 56 
                 +++   +L s +++lk e 
  EFC39342.1 192 IDSNFVKLLSSISNLKREL 210
                 4444455666666666655 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.07
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  33 rrvkaLekeNksLkseleelkkevekLks 61 
                 +r k L++ ++++  ele+++ +v++ ++
  EFC39342.1 283 ERLKGLKSTMEKMYIELENITGKVKNVQQ 311
                 58899***************999988776 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 2.9e-05
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  28 ieeLerrvkaLekeNksLkseleelkkevekL 59 
                 i++ e++ +++e+eN++L+++++el+ e+e+L
  EFC39342.1 317 IKQTETQIQEFEQENEDLRKRIQELETENEEL 348
                 7888999**********************998 PP

  == domain 4  score: 11.1 bits;  conditional E-value: 0.00023
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_1  26 aeieeLerrvkaLekeNksLkseleelkkevekLksk 62 
                 +e e L +r ++Le+eN++L    + l kev+kL+++
  EFC39342.1 329 QENEDLRKRIQELETENEELGHHKKLLIKEVKKLRTE 365
                 67899*****************************987 PP

>> DUF812  Protein of unknown function (DUF812)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7  29.1    0.0085        12     131     380 ..     116     372 ..      95     374 .] 0.67

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0085
      DUF812 131 aealrsqlaapwlpeeckakqelqgsrkvraf.rtqpleipkaskgkskenskelkefykellplvtaqlssraslvpslleenaaelaaeqeweeean 228
                  +a++++la ++++   +    ++g++ +++  ++++l  +++s++k+ en +++++f ke+++ +++q  ++  +++ + ++  + l++ ++ ++e +
  EFC39342.1 116 LSASKEKLAQQATARKRS--VAVNGNSPTNQPeNMFKLDSSENSGPKNMEN-STVNSFEKEKIDRLQKQKDESLMILQQIDSNFVKLLSSISNLKRELE 211
                 344455555554444433..3455555554440445888889999977776.678999999******99888888889998899999999999999999 PP

      DUF812 229 eqglasrlteeeykkrk.....keklqkrlaeqlrkaalkseeaessasksksdlaellsefseksetdslktkgsrfthaekl..qftke..elakka 318
                 ++ l++   ++e k+       ++k  +   + ++ +  +++ +es++ k + d   +l   + ++  + ++  +   +  ek+  ++++   ++++ +
  EFC39342.1 212 SSTLETVEPNQETKEVTstpssRKKKATSSDDDFSDSGFDTSDSESENVKPTFDPTAILAPSTVADLMNPVERLKGLKSTMEKMyiELENItgKVKNVQ 310
                 999955445555555445555556666666667777777777777777777777777776664333333333222222333333233333333344789 PP

      DUF812 319 eteeelkkkreeeleelqeqieeleskieeleeeikklessikqveeeleeekeeneeleke 380
                 +++e+l k+ e++++e +++ e+l+++i+ele e ++l  + k + +e++++++e+++ + +
  EFC39342.1 311 QDQEDLIKQTETQIQEFEQENEDLRKRIQELETENEELGHHKKLLIKEVKKLRTETSQPQTQ 372
                 9999***************************************9999999999999887766 PP

>> Spc7  Spc7 kinetochore protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   3.2     0.017        24     218     260 ..     171     213 ..     109     240 .. 0.82
   2 ?    7.5  13.5    0.0012       1.6     171     254 ..     287     370 ..     273     374 .] 0.70

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.017
        Spc7 218 kkkelaelqeqleeleekieelkeqkseleeeiaeaervleec 260
                  k+++++lq+q++e+   +++++++  +l + i++ +r le  
  EFC39342.1 171 EKEKIDRLQKQKDESLMILQQIDSNFVKLLSSISNLKRELESS 213
                 4788999999999999999999999999999999999988765 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0012
        Spc7 171 eleeekaeleeeleklqeaaeelesidkeeLeelreelaelkaeieekkkelaelqeqleeleekieelkeqkseleeeiaeae 254
                  l++  +++  ele++  +++++++ +++ ++++  +++e ++e e ++k+++el+++ eel    + l ++ ++l++e+++ +
  EFC39342.1 287 GLKSTMEKMYIELENITGKVKNVQQDQEDLIKQTETQIQEFEQENEDLRKRIQELETENEELGHHKKLLIKEVKKLRTETSQPQ 370
                 233333333344445555666677778888899999999999999999999999999999999998888888888888887765 PP

>> ZapB  Cell division protein ZapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.1      0.24   3.3e+02      15      39 ..     108     132 ..     101     156 .. 0.82
   2 ?   -0.2   1.0         1   1.4e+03       3      24 ..     186     207 ..     166     212 .. 0.46
   3 ?    2.7   1.0      0.13   1.7e+02       3      45 ..     186     228 ..     184     259 .. 0.82
   4 ?    1.0   0.2      0.42   5.8e+02      19      56 ..     274     314 ..     271     320 .. 0.68
   5 ?   12.3  13.5   0.00013      0.17       5      58 ..     316     369 ..     313     373 .. 0.91

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.24
        ZapB  15 kaidtitlLqmeieeLkeeneelke 39 
                  aid++ +L+   e+L ++  + k+
  EFC39342.1 108 RAIDKVMTLSASKEKLAQQATARKR 132
                 6888888888888888888777665 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 1
        ZapB   3 lelLeqLEskiqkaidtitlLq 24 
                 l +L+q  s   k++  i+ L+
  EFC39342.1 186 LMILQQIDSNFVKLLSSISNLK 207
                 2233333333334444444444 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.13
        ZapB   3 lelLeqLEskiqkaidtitlLqmeieeLkeeneelkeenrele 45 
                 l +L+q  s   k++  i+ L+ e+e    e  e ++e +e++
  EFC39342.1 186 LMILQQIDSNFVKLLSSISNLKRELESSTLETVEPNQETKEVT 228
                 66788888999999999*******9999999988888888887 PP

  == domain 4  score: 1.0 bits;  conditional E-value: 0.42
        ZapB  19 titlLqmeieeLkeeneelkeenrele...eeneqlkeere 56 
                 t++ L + +e+Lk  ++++++   ele    ++++ ++++e
  EFC39342.1 274 TVADLMNPVERLKGLKSTMEKMYIELEnitGKVKNVQQDQE 314
                 67778888888888888888888888755545555555554 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 0.00013
        ZapB   5 lLeqLEskiqkaidtitlLqmeieeLkeeneelkeenreleeeneqlkeereaw 58 
                 l +q E++iq+  ++ + L+++i+eL+ eneel   ++ l +e+++l++e ++ 
  EFC39342.1 316 LIKQTETQIQEFEQENEDLRKRIQELETENEELGHHKKLLIKEVKKLRTETSQP 369
                 5677899*****************************************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2633  (0.146857); expected 358.6 (0.02)
Passed bias filter:                      605  (0.0337442); expected 358.6 (0.02)
Passed Vit filter:                       125  (0.00697194); expected 17.9 (0.001)
Passed Fwd filter:                        43  (0.00239835); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.88u 0.35s 00:00:01.23 Elapsed: 00:00:00.52
# Mc/sec: 2170.10
//
Query:       EFC39343.1  [L=657]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (657 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2213  (0.123431); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        36  (0.00200792); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.51u 0.41s 00:00:01.92 Elapsed: 00:00:00.63
# Mc/sec: 3148.89
//
Query:       EFC39344.1  [L=680]
Description: adenylate kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.4e-16   57.8   0.1    1.3e-15   56.8   0.1    1.5  1  Dpy-30          Dpy-30 motif
    2.8e-10   40.5   0.2    3.8e-07   30.3   0.0    3.1  3  ADK             Adenylate kinase
    5.2e-07   30.2  13.3    1.3e-05   25.7   0.9    3.5  2  AAA_17          AAA domain
    0.00055   20.1   6.9     0.0016   18.6   0.0    3.5  3  AAA_33          AAA domain
    0.00074   18.8   1.3    0.00074   18.8   1.3    1.9  2  G-alpha         G-protein alpha subunit
     0.0012   18.3   7.1     0.0012   18.3   7.1    2.2  2  BUD22           BUD22
     0.0024   17.6   0.2      0.007   16.1   0.0    1.9  2  AAA_24          AAA domain
  ------ inclusion threshold ------
      0.076   13.2   6.0        2.5    8.2   0.9    2.2  2  DDHD            DDHD domain
       0.11   12.8   2.8        2.5    8.4   0.0    2.8  3  AAA_22          AAA domain
        3.3    7.7  18.3       0.63   10.1   4.9    2.3  2  TERB2           Telomere-associated protein TERB2
        3.6    7.9   5.7         15    5.9   0.3    2.7  3  SET             SET domain


Domain annotation for each model (and alignments):
>> Dpy-30  Dpy-30 motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   56.8   0.1     8e-19   1.3e-15       1      40 [.     636     675 ..     636     677 .. 0.96

  Alignments for each domain:
  == domain 1  score: 56.8 bits;  conditional E-value: 8e-19
                 -HHHHHHHHTHHHHHHHHHHHHHH--SSHHHHHHHHHHHH CS
      Dpy-30   1 parkYLnktvaPiLlqGLtelAkeRPeDPieyLAeYLlkn 40 
                 p r YL+++v P+L++GL e++  +PeDP++yLAe+L+k+
  EFC39344.1 636 PLRVYLMENVIPVLTKGLIEVCQMQPEDPVDYLAEWLFKQ 675
                 6799**********************************97 PP

>> ADK  Adenylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.7   0.0    0.0043         7       1      27 [.     272     298 ..     272     331 .. 0.88
   2 !   30.3   0.0   2.4e-10   3.8e-07      55     138 ..     409     510 ..     389     520 .. 0.78
   3 ?   -3.4   0.2       5.8   9.5e+03      84     104 ..     600     620 ..     585     637 .. 0.64

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0043
                 EEESTTSSHHHHHHHHHHHHTSEEEEH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK   1 llGaPgaGKGtqaeklvkkyglahlst 27 
                 ++G+PgaGK   ++++++ky l  + +
  EFC39344.1 272 MIGPPGAGKSHYSAQMKRKYRLDVVNS 298
                 58******************9877655 PP

  == domain 2  score: 30.3 bits;  conditional E-value: 2.4e-10
                 --HHHHHHHHHHHHHCH.GTTTEEEEESB-SSHHHHHHH.......HHHHH....HHTSEESEEEEEE--HHHHHHHHHT........GSHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxx.......xxxxx....xxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxx RF
         ADK  55 vpdevvvklvkeeleke.dkkkgfllDGfPRtveqaeal.......eelle....eekvkldlvleldvpeevlveRltg........DneetvkkRle 133
                   d  ++++ + +l+++   ++g++lDGfP+tveqa+ l       ++  e    +++   d+ + ++++e+vl +Rl +        + ++  k+Rle
  EFC39344.1 409 YNDTAITEMFRWKLSQPrLLNHGWILDGFPKTVEQAKLLfikraegDD--EpkgvDDHLFPDYCIIFNCKEKVLEDRLINitdptpghNDQDGFKRRLE 505
                 5788999*********97789***************987433222111..1111123445799************************988999****** PP

                 HHHHH CS
                 xxxxx RF
         ADK 134 tykkq 138
                 +++k+
  EFC39344.1 506 AFNKA 510
                 **986 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 5.8
                 SSHHHHHHHHHHHHHHTSEES CS
                 xxxxxxxxxxxxxxxxxxxxx RF
         ADK  84 Rtveqaealeelleeekvkld 104
                 R+ +qae+ e++l +++ +l+
  EFC39344.1 600 RKRKQAEERERVLRSDAERLE 620
                 666677776666655554444 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.7   0.9   7.7e-09   1.3e-05       1      71 [.     273     347 ..     273     363 .. 0.68
   2 !   11.7   0.0   0.00016      0.26      64     121 ..     421     486 ..     388     498 .. 0.72

  Alignments for each domain:
  == domain 1  score: 25.7 bits;  conditional E-value: 7.7e-09
                 EE-TTSSHHHHHHHHHHHHTEEEEEHHHHHH...HHHHTTTSHSSHHHHC..TSHHHHHHHHHHHHHHHHHHHHHS CS
      AAA_17   1 lGgPGsGKgtqceklvekygfthlsaGdllr...eeakrgglakardemr..klpleekkelqkeaaekiaeeakk 71 
                 +G+PG+GK+++++++++ky + +++ ++++    + +k++++ + ++ ++  k ++e+ k+l+ + +++++e++kk
  EFC39344.1 273 IGPPGAGKSHYSAQMKRKYRLDVVNSSSVISdfeALVKEKEA-TYHNLVQekKDKIEHAKQLRLQKKKELEEKKKK 347
                 69****************************975334444443.222323233556666666666666666666533 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00016
                 HHHHHH.HSSEEEEEE-SEEEETTEEE.......ESSHHHHHHHH..SEEEEEE--HHHHHHHHHH CS
      AAA_17  64 kiaeea.kkkgvlvdghprikeqagfl.......dglpkevleelkpdaiilleadpeeilerrlk 121
                 k+ + +  ++g+++dg+p + eqa++l       d+ pk v + l+pd +i+++++++++ +r+++
  EFC39344.1 421 KLSQPRlLNHGWILDGFPKTVEQAKLLfikraegDDEPKGVDDHLFPDYCIIFNCKEKVLEDRLIN 486
                 44554457899*********99966542222212556677889**************988777764 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.0   9.9e-07    0.0016       2      58 ..     270     326 ..     270     348 .. 0.74
   2 ?    2.0   0.0      0.13   2.1e+02      94     117 ..     463     486 ..     448     512 .. 0.80
   3 ?   -2.7   4.7       3.8   6.2e+03     106     137 ..     567     602 ..     494     608 .. 0.55

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 9.9e-07
      AAA_33   2 vllvGlpGsGKstlaerllkklgavllssdtlrrrlfgtdqqsktdytrvldrlyqi 58 
                 +l++G+pG+GKs+++ ++ +k    +++s ++++  ++  ++++  y ++ ++ ++ 
  EFC39344.1 270 ILMIGPPGAGKSHYSAQMKRKYRLDVVNSSSVISDFEALVKEKEATYHNLVQEKKDK 326
                 69*******************99******9988887775555555555554444433 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.13
      AAA_33  94 rlgvpvrivvvetdeetlkeRlak 117
                 ++ +p+ ++++++ e++l++Rl  
  EFC39344.1 463 DHLFPDYCIIFNCKEKVLEDRLIN 486
                 67799****************976 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3.8
      AAA_33 106 tdeetlkeRlakRaang....ddrsevpeealdrqk 137
                 + e++lke+ ++Raa++    +++ + ++ al+r +
  EFC39344.1 567 PTEKELKEKERRRAAREdeqqKQEQQKHQNALERKR 602
                 455566665555555541113333445555555555 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   1.3   4.5e-07   0.00074      10     120 ..     254     384 ..     248     446 .. 0.72
   2 ?   -1.8   1.0      0.84   1.4e+03      59      90 ..     536     578 ..     493     645 .. 0.51

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 4.5e-07
                 XXXXXXXXXXE..EEEEEEEESTTSSHHHHHHHHHHHCS--.......--HHHH.HCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCC CS
     G-alpha  10 slkaerkarkkkrevkllllGqseSGKsTilkqlkllykkg.......fseeel.atwraviqlnivrsiktilealesleselsesfelqelkerldp 100
                 ++k+e +++++  ++++l++G  + GKs +  q+k+ y+         +s+ e+  + ++  ++n+v+  k+ +e  ++l  +   + el+e k++ ++
  EFC39344.1 254 KIKQEFEKKRNLAPLRILMIGPPGAGKSHYSAQMKRKYRLDvvnsssvISDFEAlVKEKEATYHNLVQEKKDKIEHAKQLRLQK--KKELEEKKKKQEE 350
                 688998888888999********************999777665666644445535567799***************9975555..4466777777777 PP

                 CS-HCHHHH........................H CS
     G-alpha 101 lkkveasliaklssateee..............q 120
                  k+  ++  ++ ++++ee               +
  EFC39344.1 351 AKNDGDDDEDNQEPPQEEDpeepaeedkeeeegS 384
                 7777777777777888777666666555444442 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.84
                 CHHHHHHHHHHHHHHHHHHHHHT.T.................H CS
     G-alpha  59 wraviqlnivrsiktilealesl.eselsesf..........e 90 
                 +++ + + + r+ k il +++++ +++++  +           
  EFC39344.1 536 ITKEVVFETERDEKEILTEVKEFlGKPHNYGPtekelkekerR 578
                 3333333444444445555544323333222233332222220 PP

>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   7.1   7.2e-07    0.0012     103     224 ..     284     401 ..     267     455 .. 0.67
   2 ?    3.5   9.8     0.022        36     125     192 ..     549     617 ..     543     642 .. 0.45

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 7.2e-07
       BUD22 103 ktkalenvtsrLlnsktvkevveeivesvkkllgiekkkkkkeeekkkkkkkkkkkkkkeeeeeeesdkeeesedsedeekeeseddeeeeeededded 201
                 + ++ ++++  ++ns+ v + +e+ v++ +   +  + ++kk++ +++k+ + +kkk+ ee+++++++++++ +d+ed ++e  ++++ ee ++ed+e+
  EFC39344.1 284 SAQMKRKYRLDVVNSSSVISDFEALVKEKEATYHNLV-QEKKDKIEHAKQLRLQKKKELEEKKKKQEEAKNDGDDDED-NQEPPQEEDPEEPAEEDKEE 380
                 5556677777888888888888888887666665444.4444455555555555555555555445555555555555.45555555555555555444 PP

       BUD22 202 aeedeedeeaeerelaqydglla 224
                 +e  ++     ++e+++y+++l+
  EFC39344.1 381 EE--GSPIFVAKQEFEKYKAILD 401
                 33..4556666778888887666 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.022
       BUD22 125 eeivesvkkllgiek...kkkkkeeekkkkkkkkkkkkkkeeeeeeesdkeeesedsedeekeeseddeee 192
                 +ei ++vk++lg +     ++k+ +ek++++++++++++k+e+++ ++  e +++++e+   e+  +++ e
  EFC39344.1 549 KEILTEVKEFLGKPHnygPTEKELKEKERRRAAREDEQQKQEQQKHQNALERKRKQAEE--RERVLRSDAE 617
                 689999******88844422222222222222222222222222122222222222222..1111111111 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.0       4.4   7.2e+03      36      60 ..      23      56 ..      17      67 .. 0.69
   2 !   16.1   0.0   4.3e-06     0.007       2      95 ..     267     345 ..     266     356 .. 0.71

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 4.4
      AAA_24 36 ksldadkfpdie.........swedfldevvela 60
                k ++a++f++++         sw++ ++ ++e +
  EFC39344.1 23 KVIEAAEFNEPKtmillstsmSWAMTRKSFTEAD 56
                5666677776667777777788888888888773 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 4.3e-06
      AAA_24   2 klkiliyGpsgiGKTtlakelgpkplfidtekGlksldadkfpdieswedfldevvelaaeladyktlviDtideleelclaevirqnekaesk 95 
                 +l+il++Gp+g+GK++  +++ ++   +d+ +++  + + +                +++++a+y+ lv    d++e  +   +++++e +e+k
  EFC39344.1 267 PLRILMIGPPGAGKSHYSAQM-KRKYRLDVVNSSSVISDFEAL--------------VKEKEATYHNLVQEKKDKIEHAKQLRLQKKKELEEKK 345
                 579******************.999999999988888877755..............6778888888887666666555555444444443333 PP

>> DDHD  DDHD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.3    0.0024         4     106     163 ..     317     374 ..     259     469 .. 0.56
   2 ?    8.2   0.9    0.0016       2.5     100     170 ..     543     619 ..     500     670 .. 0.45

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0024
        DDHD 106 sglvsslsallnrslelaeeesaslaessksherasesskasqeskaaesstasssak 163
                 ++lv++ +  +++ ++l  +++++l+e++k++e+a+++ ++++ +++  +++ +++ +
  EFC39344.1 317 HNLVQEKKDKIEHAKQLRLQKKKELEEKKKKQEEAKNDGDDDEDNQEPPQEEDPEEPA 374
                 1122222222333333444444444444444433333333333322222222222222 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0016
        DDHD 100 alkqkvsglvsslsallnrslelaeeesaslaessksherasesskasqeskaaesstasssaksskaee..........k 170
                 ++++ +++++++++     +l+   +  ++++e +++++r++++++++q+++++++++a ++++++++e+           
  EFC39344.1 543 ETERDEKEILTEVKE----FLGKPHNYGPTEKELKEKERRRAAREDEQQKQEQQKHQNALERKRKQAEERervlrsdaerL 619
                 333444444444443....22222222222222233333333333333333333333333333322222222333332220 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       5.6   9.2e+03      90     103 ..     177     189 ..     157     199 .. 0.72
   2 ?    8.4   0.0    0.0016       2.5       8      40 ..     270     293 ..     268     353 .. 0.59
   3 ?    3.3   0.6     0.057        93      38      71 ..     531     582 ..     502     642 .. 0.62

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 5.6
      AAA_22  90 avielliiDEaqhl 103
                 +  ++l +DE q  
  EFC39344.1 177 QQ-AFLAVDESQLT 189
                 33.78888888865 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0016
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaeeerp 40 
                 ++ +G++G+GK++  +++++++         r 
  EFC39344.1 270 ILMIGPPGAGKSHYSAQMKRKY---------RL 293
                 5779***********9999998.........22 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.057
      AAA_22  38 erpevv..fvtlpsstsskdllrellralglelka................e 71 
                 ++++++  +v    + + k++l+e+ ++lg ++++                +
  EFC39344.1 531 QKRQCItkEVVFETERDEKEILTEVKEFLGKPHNYgptekelkekerrraaR 582
                 455555446666677799*****************77776555554333320 PP

>> TERB2  Telomere-associated protein TERB2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   5.5     0.051        83      86     189 ..     295     408 ..     282     424 .. 0.60
   2 ?   10.1   4.9   0.00038      0.63      58     155 ..     514     606 ..     509     646 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.051
       TERB2  86 vLppakvqeeirkkigrfiweqdnqslveqssevhsaeepeiakdslleekeeqasklaksaeksatstsksekqlcselk..........eyPvnnvv 174
                 v +  +v  ++ + + +     +n ++ ++ + +h+++   ++k++l+e+k++q + ++++ ++++ + + +e+ +  +++           +  ++  
  EFC39344.1 295 VVNSSSVISDFEALVKEKEATYHNLVQEKKDKIEHAKQLRLQKKKELEEKKKKQEEAKNDGDDDEDNQEPPQEEDPEEPAEedkeeeegspIFVAKQEF 393
                 556666777777777776666666555544444555555555555555555555555566666888888888877777664333444444455555555 PP

       TERB2 175 tgyvsidelkkysGe 189
                 + y  i +lk+ sG 
  EFC39344.1 394 EKYKAILDLKENSGR 408
                 566666555555555 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00038
       TERB2  58 drlTvFhssylsaaknekskksvalgkyvLppakvqeeirkkigrfiweqdnqslveqssevhsaeepeiakdslleekeeqasklaksaeksatsts 155
                 ++lT +   y+ +++ e+ +++++  + v  +++ ++ei   + +f+++ +n   +e++ +++ +++   + +++++e++++++ l+++      ++ 
  EFC39344.1 514 NNLTTYLLGYIEECVTEQKRQCIT-KEVVFETERDEKEILTEVKEFLGKPHNYGPTEKELKEKERRRAAREDEQQKQEQQKHQNALERKR----KQAE 606
                 688999999*********999997.678************************99999988866555555544444444444444432221....1111 PP

>> SET  SET domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       7.8   1.3e+04      54      90 ..      33      69 ..      16     102 .. 0.67
   2 ?    5.9   0.3    0.0092        15      53      95 ..     330     378 ..     159     449 .. 0.75
   3 ?    4.8   0.2     0.021        34      42      91 ..     572     604 ..     466     660 .. 0.63

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 7.8
                HHHHHHTTSSHHHHHHHHHHHHHHHHHHTHHHHHHHX CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         SET 54 elakasastllqklakdqkqaekedtdaalkasskae 90
                 +++  +st+++++  + +  e +++d a k   k +
  EFC39344.1 33 PKTMILLSTSMSWAMTRKSFTEADQDDEAEKPLRKPY 69
                4555566667777777766666666666666655544 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0092
                 HHHHHHHTTSSHHHHHHHHHHHHHHHHHHTHHHHHHHXTTTS......X CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......x RF
         SET  53 kelakasastllqklakdqkqaekedtdaalkasskaesdln......a 95 
                   +  ++++++l++ +k+q++a+++ +d++ ++++  e+d +      +
  EFC39344.1 330 AKQLRLQKKKELEEKKKKQEEAKNDGDDDEDNQEPPQEEDPEepaeedK 378
                 4566689999999999999999999999999999999998864444330 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.021
                 EEXGGXXGGSX.HHHHHHHTTSSHHHHHHHHHHHHHHHHHHTHHHHHHHXT CS
                 xxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         SET  42 lpeapknlaft.kelakasastllqklakdqkqaekedtdaalkasskaes 91 
                 l         + ke++ a+ + + qk +++ +q+           + k ++
  EFC39344.1 572 L---------KeKERRRAAREDEQQKQEQQKHQNAL---------ERKRKQ 604
                 1.........12333444443333333333333333.........322222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (680 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3252  (0.181382); expected 358.6 (0.02)
Passed bias filter:                      986  (0.0549947); expected 358.6 (0.02)
Passed Vit filter:                       244  (0.0136092); expected 17.9 (0.001)
Passed Fwd filter:                        75  (0.00418317); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 1.07u 0.37s 00:00:01.44 Elapsed: 00:00:00.56
# Mc/sec: 3638.43
//
Query:       EFC39345.1  [L=132]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (132 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       657  (0.0366445); expected 358.6 (0.02)
Passed bias filter:                      437  (0.0243739); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 806.48
//
Query:       EFC39346.1  [L=133]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-12   47.6   0.0    3.2e-12   46.8   0.0    1.5  1  PseudoU_synth_2  RNA pseudouridylate synthase


Domain annotation for each model (and alignments):
>> PseudoU_synth_2  RNA pseudouridylate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.8   0.0   1.8e-16   3.2e-12      40     145 ..       6     127 ..       2     130 .. 0.68

  Alignments for each domain:
  == domain 1  score: 46.8 bits;  conditional E-value: 1.8e-16
  PseudoU_synth_2  40 elklvhRLDkatsGllllAksseaanklakafeerkvrKkYlalvfgapeeeegaikkkiskd....................tekqegarrka 113
                       l + hR+D+ tsG+l+l+ksse a+ ++ ++++++v K+Y+a+ + +  ++eg +k +                        ++k+       
       EFC39346.1   6 DLFPLHRIDRLTSGVLILGKSSEVARDFSASLKSKQVGKQYIAVAE-GICPTEGLFKVDYPLMeidpllgiwravhseeskefIKKHYLHHTPL 98 
                      6889*****************************************8.66666665554433334455566666666666655322332223333 PP

  PseudoU_synth_2 114 eeldgkkavtylkvlksgsseksakvslvele 145
                        ++ k+a+t ++vl ++     ++ ++  ++
       EFC39346.1  99 DWNNVKEAETLFQVLYRD---YASNRTVFLCQ 127
                      445566777777777777...55555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (133 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       305  (0.0170115); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 802.32
//
Query:       EFC39347.1  [L=248]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.4e-10   40.1   0.0    5.8e-10   39.7   0.0    1.2  1  2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.7   0.0   3.3e-14   5.8e-10       2     196 .]       4     216 ..       3     216 .. 0.72

  Alignments for each domain:
  == domain 1  score: 39.7 bits;  conditional E-value: 3.3e-14
  2OG-FeII_Oxy_2   2 lllipnflsaeeaaellrelleegpfrqptilggkrvsvqqtllgplgwatdgpgyrysekesvdakplspfpeallrlverlvkaag.....pe 91 
                     +++ip+++++ee ++ ++ + +   + ++   ++  v + ++ l++lg  ++++g   ++  +   + ++++++   + ++++    +     ++
      EFC39347.1   4 IYYIPDYITEEEEKKCVEAIYKDDTSSSYVGEKKGWVCLSKRRLKNLGGIPHPNGMYKESL-PKYITDFRKLLHQKGHSIDKFI---EipsdqVK 94 
                     5899999999999999999996666555555554445555555789999997765444434.6666666666654444444444...35668899 PP

  2OG-FeII_Oxy_2  92 gwspnaalvnfYrdgariglHqDkeesaleapivSlSLGasatfrfgkesree.....eiiailLesGdllvmgges.rkayHgvprikkd.... 176
                     ++++n++l n Y+ g+ i  H+D   +  ++  + lSL +++ + f +e+ +e        ++ Le+ +ll++  e+   ++Hgv+ +++d    
      EFC39347.1  95 NHDYNQVLLNEYECGKGIRPHKDGPLY--SDIALVLSLKTTSLIDFYTEKPTEeneesVLASVFLEPRSLLIFCKEAyTDYFHGVRDVDQDvinp 187
                     *************************77..677777888888888885443222233447789***************55666*********7777 PP

  2OG-FeII_Oxy_2 177 .......tapele......leelrtrRinlTfR 196
                            t    +      +   +t R++lT+R
      EFC39347.1 188 ekcinmqT----AnvsagqIIPRNTTRLSLTIR 216
                     77766553....045558866779*******99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (248 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       571  (0.0318478); expected 358.6 (0.02)
Passed bias filter:                      398  (0.0221987); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.54
# Mc/sec: 1379.71
//
Query:       EFC39348.1  [L=379]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.2e-16   58.5  11.0    6.6e-16   57.9  11.0    1.3  1  zf-C3HC4_3   Zinc finger, C3HC4 type (RING finger)
    1.1e-08   34.7  11.6      2e-08   34.0  11.6    1.4  1  Prok-RING_4  Prokaryotic RING finger family 4
    3.3e-06   27.2   0.1    5.7e-06   26.5   0.1    1.4  1  SPRY         SPRY domain
    0.00014   22.1  11.9    0.00024   21.4  11.9    1.4  1  zf-RING_2    Ring finger domain
      0.007   16.2  13.1      0.014   15.2  13.1    1.5  1  zf-C3HC4_2   Zinc finger, C3HC4 type (RING finger)
  ------ inclusion threshold ------
      0.014   15.3  12.6      0.029   14.3  12.6    1.5  1  zf-RING_5    zinc-RING finger domain
      0.026   13.9  17.3      0.049   13.0  17.3    1.4  1  GAS          Growth-arrest specific micro-tubule binding
        0.3   11.5   6.6       0.54   10.6   6.6    1.3  1  Cgr1         Cgr1 family
       0.42   10.5   8.3        0.9    9.4   8.3    1.5  1  zf-RING_4    RING/Ubox like zinc-binding domain


Domain annotation for each model (and alignments):
>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.9  11.0   3.3e-19   6.6e-16       3      49 ..     327     373 ..     325     374 .. 0.95

  Alignments for each domain:
  == domain 1  score: 57.9 bits;  conditional E-value: 3.3e-19
                 SB-TTTSSSBS-EEETTEEEEEE-HHHHHHHHHTT-B-TTT--B--E CS
  zf-C3HC4_3   3 eeCviClerprnvvllpCgHlvlCeeCaekllkrkkkCpiCrrpiek 49 
                  +Cv+C+++++n+++lpC+Hl++C eCae++++  k+Cp+Cr+ i++
  EFC39348.1 327 LLCVVCQDKRKNTLFLPCKHLCVCAECAESVKSTGKQCPVCRTVISD 373
                 68*****************************99**********9986 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.0  11.6   9.9e-12     2e-08       1      43 [.     329     374 ..     329     377 .. 0.95

  Alignments for each domain:
  == domain 1  score: 34.0 bits;  conditional E-value: 9.9e-12
  Prok-RING_4   1 CvlCgeqekkailepCgHl.vCkeCfdskdls..sCPlCqrrisks 43 
                  Cv+C+ ++k+  + pC+Hl vC eC +s +++  +CP+C++ is+s
   EFC39348.1 329 CVVCQDKRKNTLFLPCKHLcVCAECAESVKSTgkQCPVCRTVISDS 374
                  ******************************9999******999875 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.5   0.1   2.8e-09   5.7e-06       3      97 ..      62     156 ..      60     178 .. 0.82

  Alignments for each domain:
  == domain 1  score: 26.5 bits;  conditional E-value: 2.8e-09
                 EEEEEET..CCTSSEEEEEEEETTSSSSSTSSSTSSTTEEEEETETTEEEEETESCEEEESSSS...TTSEEEEEEETTTTEEEEEETTEEEEEEEEST CS
        SPRY   3 yfevkiq..saeggsisvGlateqtdlsdksgegddrgswglcgdngtrtsaeqskaygkqpar...egdviGvalDleegelsFtkngknlgvaFrnv 96 
                 yfe+ iq  s+++    +Gla+ ++d   + + g+ ++s+g++ d+g +++++ +++ +++  +    gd +Gv+l  +  +  Ftkng     aF+  
  EFC39348.1  62 YFEIFIQhvSEKKPIFAIGLAKPNYD---RGMVGWYDESIGYHADDGYVFHNVGNQHNTENLIGlysFGDSVGVLLIGS--KAYFTKNGVANTKAFELK 155
                 **************************...45559****************7777777777665544489******9888..99******8888888754 PP

                 T CS
        SPRY  97 r 97 
                 +
  EFC39348.1 156 N 156
                 4 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.4  11.9   1.2e-07   0.00024       3      44 .]     329     368 ..     327     368 .. 0.84

  Alignments for each domain:
  == domain 1  score: 21.4 bits;  conditional E-value: 1.2e-07
   zf-RING_2   3 CpICleelssadsvlllpCgHv.fhreClerwlrssstCPlCr 44 
                 C++C+   ++++++l lpC+H   + eC+e    + ++CP+Cr
  EFC39348.1 329 CVVCQ---DKRKNTLFLPCKHLcVCAECAESVKSTGKQCPVCR 368
                 ****9...677889999****659****9996666666****9 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2  13.1     7e-06     0.014       2      40 .]     329     367 ..     328     367 .. 0.91

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 7e-06
  zf-C3HC4_2   2 CpiCldmlkdpsvvtpCgHv.fCqkCilrsLeekneCPlC 40 
                 C +C+d  k++    pC+H   C++C     + +++CP+C
  EFC39348.1 329 CVVCQDKRKNT-LFLPCKHLcVCAECAESVKSTGKQCPVC 367
                 **********7.888****637*******989999***** PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3  12.6   1.5e-05     0.029       2      44 .]     329     369 ..     328     369 .. 0.93

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.5e-05
   zf-RING_5   2 CnkCfeklskeekfyltsCgHi.fCekClkkllekeavCpiCrk 44 
                 C +C +k    ++  +++C+H  +C +C+   +   ++Cp+Cr+
  EFC39348.1 329 CVVCQDKR---KNTLFLPCKHLcVCAECAESVKSTGKQCPVCRT 369
                 88999888...999*******988******************95 PP

>> GAS  Growth-arrest specific micro-tubule binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0  17.3   2.4e-05     0.049      18     108 ..     210     300 ..     209     325 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.4e-05
         GAS  18 nditrnNLelIkslKeeieelkkkeernekelseisqenkrlkepLkkaeeeveeLrkqlknyekdkqslknlkarlkelekelkdlkweh 108
                 nd  ++ L+  + lK+ i +  +++  n+ + ++  +e ++lk ++++++  +e+L++q +   k+ ++l+ +k+rl   ++ +++l++e+
  EFC39348.1 210 NDSANDMLNHCDGLKKLILDVIEQQSVNDSLQKQKDTEIQKLKIEITELQSSNEKLKQQHEITLKENEKLRDVKTRLALNQQDINNLSLEQ 300
                 5667788999999**************************************************************************9886 PP

>> Cgr1  Cgr1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   6.6   0.00027      0.54      36      97 ..     241     302 ..     229     306 .. 0.93

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00027
        Cgr1  36 rqekrkkakaiKklekeLkdekeaerqrrieaikerrkakeEkeRleelaakmhakkveRlk 97 
                 +++k+++ +++K   +eL++  e+ +q++   +ke+ k +  k Rl+  ++ +++  +e+lk
  EFC39348.1 241 QKQKDTEIQKLKIEITELQSSNEKLKQQHEITLKENEKLRDVKTRLALNQQDINNLSLEQLK 302
                 57899999**********************************************99999998 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   8.3   0.00045       0.9       3      45 ..     328     369 ..     327     371 .. 0.77

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00045
   zf-RING_4   3 lCdeeldetdkd.lkpCeCgyqiClfCyhrileeeegrCPaCre 45 
                 lC+ + d++ ++ + pC+ +  +C  C + +++ ++++CP Cr+
  EFC39348.1 328 LCVVCQDKRKNTlFLPCK-HLCVCAECAESVKS-TGKQCPVCRT 369
                 577777666554167887.5679****999996.7********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (379 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2277  (0.127001); expected 358.6 (0.02)
Passed bias filter:                      572  (0.0319036); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.68u 0.36s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2061.22
//
Query:       EFC39349.1  [L=1049]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.5e-09   36.3   1.2     0.0013   19.0   0.3    2.7  2  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   9.2e-07     0.017       2      90 ..     439     524 ..     438     548 .. 0.83
   2 !   19.0   0.3   7.2e-08    0.0013      50     117 ..     616     717 ..     612     718 .. 0.95

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 9.2e-07
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTT CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklf 90 
                 +++l++++ gr++F  F+++ +++e+++F++++ ++ +  + + l k      n++++++ p +++++++  ++l ++l+   ps++ f
  EFC39349.1 439 FRQLMDSENGREIFFAFIQKHSHSEQIEFLQETIRLYQD-NASVLPKCTSPSSNAHIHENTPFSVSLPDNGDNQLGRCLSP--PSSSSF 524
                 899******************************999999.89999999999999999999999999999999988888877..666655 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 7.2e-08
                 HHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS..................................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHH CS
         RGS  50 akeIyneylapsspkelnidkklreelekrleke..................................qpsrklfeeaqeevfellekdsypkFlksel 114
                 +++++n+++ ++spkeln++k+ r+++ + +ek                                   ++  ++f e+ + +   l+ +++++F +s+ 
  EFC39349.1 616 IDNLVNKFILEHSPKELNLSKRQRQKVLDLFEKLknekleflnrevyvegagvkkipytlytdilvteEEFVEIFREIISVINLQLKLECFREFRRSKE 714
                 6789***********************9998888888************************************************************** PP

                 HHH CS
         RGS 115 ylr 117
                 yl+
  EFC39349.1 715 YLD 717
                 986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1049 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1438  (0.0802053); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.88u 0.28s 00:00:01.16 Elapsed: 00:00:00.51
# Mc/sec: 6131.01
//
Query:       EFC39350.1  [L=507]
Description: hypothetical protein NAEGRDRAFT_81313 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       884  (0.0493056); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 3353.02
//
Query:       EFC39351.1  [L=467]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00041   21.1   6.0          5    8.2   0.2    4.7  4  WD40      WD domain, G-beta repeat


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.5   0.0    0.0041        73      20      36 ..      51      67 ..      44      69 .. 0.86
   2 ?    0.3   0.0     0.083   1.5e+03      25      36 ..     109     120 ..      91     121 .. 0.75
   3 !    8.2   0.2   0.00028         5      10      38 .]     227     256 ..     219     256 .. 0.67
   4 !    7.0   0.1   0.00066        12       6      38 .]     354     392 ..     350     392 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0041
                TTSSEEEEEETTSEEEE CS
        WD40 20 pdgawlasGsdDgtvri 36
                +d ++l+s+++Dgt+  
  EFC39351.1 51 DDYHYLLSSHYDGTICC 67
                5788999*******975 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.083
                 EEEEETTSEEEE CS
        WD40  25 lasGsdDgtvri 36 
                 + s+  Dgtvr+
  EFC39351.1 109 VYSANTDGTVRV 120
                 456655****98 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00028
                 SSS.EEEEEEETTSSE......EEEEETTSEEEEEE CS
        WD40  10 Hss.vtslafspdgaw......lasGsdDgtvriWd 38 
                 H++ v+++       +      +as+s+Dg ++ Wd
  EFC39351.1 227 HNDaVNHV------FYieeigcVASASWDGFLKYWD 256
                 63345555......22444444899**********9 PP

  == domain 4  score: 7.0 bits;  conditional E-value: 0.00066
                 EEESS...SSE...EEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   6 tltGH...ssv...tslafspdgawlasGsdDgtvriWd 38 
                 +++ H   ++v   +s++f+p +  +++ + D++ ++Wd
  EFC39351.1 354 IFKCHrtaNDVfapNSIDFNPLHGTFSTTGADKKAYFWD 392
                 678888655666669***9999999986666*******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (467 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       505  (0.0281667); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.41
# Mc/sec: 3430.80
//
Query:       EFC39352.1  [L=999]
Description: transmembrane protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.7e-29  102.4  28.8    2.7e-29  102.4  28.8    2.4  3  RSN1_7TM   Calcium-dependent channel, 7TM region, putative ph
    5.8e-07   29.4   0.6    5.8e-07   29.4   0.6    6.4  8  RSN1_TM    Late exocytosis, associated with Golgi transport
    4.6e-06   27.0   1.1    1.5e-05   25.3   1.1    1.9  1  PHM7_cyt   Cytosolic domain of 10TM putative phosphate transp
     0.0092   16.9   1.0     0.0092   16.9   1.0    5.8  7  DUF4834    Domain of unknown function (DUF4834)
  ------ inclusion threshold ------
      0.027   13.8   1.5      0.048   13.0   1.5    1.3  1  DUF4820    Domain of unknown function (DUF4820)
      0.094   12.8   0.9       0.21   11.6   0.0    2.0  2  Dynamin_N  Dynamin family
       0.16   12.2   0.0       0.16   12.2   0.0    2.9  3  Shisa      Wnt and FGF inhibitory regulator
        4.6    6.9  10.5          2    8.1   0.7    3.2  3  FAM176     FAM176 family


Domain annotation for each model (and alignments):
>> RSN1_7TM  Calcium-dependent channel, 7TM region, putative phosphate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -6.7   2.3         8   1.8e+04     106     111 ..      33      38 ..      22      51 .. 0.41
   2 !  102.4  28.8   1.2e-32   2.7e-29       2     243 ..     591     843 ..     590     850 .. 0.92
   3 ?   -2.8   1.2       1.4   3.2e+03       6      19 ..     939     952 ..     897     965 .. 0.68

  Alignments for each domain:
  == domain 1  score: -6.7 bits;  conditional E-value: 8
    RSN1_7TM 106 lvftla 111
                 l+++++
  EFC39352.1  33 LLVIVM 38 
                 111111 PP

  == domain 2  score: 102.4 bits;  conditional E-value: 1.2e-32
    RSN1_7TM   2 klivtlllvlliifwiipvafvgllsnletltkvlpflkkilelskkllsvvtgllPtlllslllallpiilrllsklqGalsrselelsvvskyfaFl 100
                 k+ ++++++++++f+++pv++v++++++  +  v +++kki+e+   ++sv+ +++P+lll   +al+p++++ l+kl+ + + se  +++++++ +Fl
  EFC39352.1 591 KITIFIVILIIFVFFTTPVVIVSSIDTFFAIPPVTETIKKIVEVGGPMMSVIFQYIPSLLLVASSALIPVFIYQLTKLEDMKTFSEFSRTILRRITIFL 689
                 5789999******************************************************************************************** PP

    RSN1_7TM 101 vvnvFlvftlagtalslleeiidnptsipkllaesl.pkasnFfityillqglagaaleLlqlvklilflikrkfls...........ktprdlaeryt 187
                  +nvF+++tl+ t l+ ++++ +np+s ++   +   +++++ fi++il ++l g a++L+ l +lil+ + ++++s            +p+d+ + + 
  EFC39352.1 690 WLNVFILPTLVLTTLDGITNFFTNPDSLANVFKNLFmSDNGSLFINFILNKTLYGLAFTLMPLLSLILYSVFTLCTSsvskklrisrsMKPKDKLK-WA 787
                 *****************************999875449********************************99988886655555555445666665.77 PP

    RSN1_7TM 188 kppsfdygteypkvllifvialiYsviaPlilpfaliyfllgylvykyqllyvydt 243
                 + +sf+    y++ +li++i++++s ++P+il+++ iyf+l y+v +  +  +y +
  EFC39352.1 788 EGDSFSLEYSYAYSILIMAIVFTFSLFSPFILLVTFIYFTLRYYVERFTIGRIYSH 843
                 8899999****************************************998877776 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 1.4
    RSN1_7TM   6 tlllvlliifwiip 19 
                  l+l+lli+f++i 
  EFC39352.1 939 ILTLFLLIVFFAIE 952
                 34555556666555 PP

>> RSN1_TM  Late exocytosis, associated with Golgi transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.1     0.074   1.6e+02       2      37 ..      23      57 ..      22      83 .. 0.75
   2 !   29.4   0.6   2.6e-10   5.8e-07      55     153 ..     178     290 ..     168     292 .. 0.85
   3 ?   -2.9   2.5       2.3   5.2e+03      10      99 ..     592     605 ..     584     617 .. 0.53
   4 ?   -2.0   0.7       1.2   2.8e+03      91     142 ..     648     696 ..     638     708 .. 0.62
   5 ?   -0.9   0.2      0.57   1.3e+03     121     149 ..     782     813 ..     733     819 .. 0.57
   6 ?    2.2   1.9     0.063   1.4e+02       7      43 ..     817     854 ..     806     864 .. 0.75
   7 ?   -3.1   1.3       2.6   5.9e+03       8      20 ..     907     919 ..     899     937 .. 0.62
   8 ?   -3.6   2.2       3.6   8.1e+03     131     154 ..     926     949 ..     917     951 .. 0.72

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.074
     RSN1_TM  2 lltslvinlvlalvflllFlilRkknkrvYaprtyl 37
                ++++++in++l ++++++++++ + +  +++ r+++
  EFC39352.1 23 VFVTIAINVILLVIVMSIYVCCIR-YCTIFNVRKKK 57
                578999999999999999988743.56666666654 PP

  == domain 2  score: 29.4 bits;  conditional E-value: 2.6e-10
     RSN1_TM  55 WipallkisdeeilekaGLDayvflrflkmlikiflvlavlalivLlPvnatggegedskesk...............sgldklsisnvsegsnrlwah 138
                 W+ a++k +++ ++++ G D + +++f ++l  +f++++vl  + L P+++t++ + d  +++               + l   si+ v    + l++h
  EFC39352.1 178 WFGAAIK-EEKRVIRNYGRDVLTYIKFHQLLWWVFTIMLVLFSALLYPIHITNQGNLDPAQKEkfsknvtglkvgssdQFLVVSSINTVIGRPDILILH 275
                 6666665.7899****************************************999988777777888888888887743346667777777788***** PP

     RSN1_TM 139 vvvayiftglvlyll 153
                 v++++i+++lvl +l
  EFC39352.1 276 VILSVITVALVLAML 290
                 *********999987 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 2.3
     RSN1_TM  10 lvlalvflllFlilRkknkrvYaprtylkgeeertpplpqkglfgWipallkisdeeilekaGLDayvflrflkmlikiflvlavlaliv 99 
                 + +++v+l++F++                                                                             
  EFC39352.1 592 ITIFIVILIIFVF----------------------------------------------------------------------------F 605
                 3333333333333............................................................................3 PP

  == domain 4  score: -2.0 bits;  conditional E-value: 1.2
     RSN1_TM  91 vlavlalivLlPvnatggegedskesksgldklsisnvsegsnrlwahvvva 142
                  l+++a  +L+Pv +++ ++ ++ +   +++++s + +++ + +lw+ v++ 
  EFC39352.1 648 SLLLVASSALIPVFIYQLTKLEDMK---TFSEFSRTILRRITIFLWLNVFIL 696
                 5667777889999888777765443...455555555444466777777665 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 0.57
     RSN1_TM 121 dklsisnvs...egsnrlwahvvvayiftglv 149
                 dkl++++ +    + ++ +  +++a++ft+  
  EFC39352.1 782 DKLKWAEGDsfsLEYSYAYSILIMAIVFTFSL 813
                 44444443322233347788888888888754 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.063
     RSN1_TM   7 vinlvlalvflllFlilRkknkrvYaprtylkg.eeer 43 
                 +i lv+++ f l + + R +  r+Y+ r ++++ +++r
  EFC39352.1 817 FILLVTFIYFTLRYYVERFTIGRIYSHRLLQHHhKKKR 854
                 46678888888888889999********9987643333 PP

  == domain 7  score: -3.1 bits;  conditional E-value: 2.6
     RSN1_TM   8 inlvlalvflllF 20 
                 ++l++++v+++lF
  EFC39352.1 907 VALIMFTVYCMLF 919
                 3333444444444 PP

  == domain 8  score: -3.6 bits;  conditional E-value: 3.6
     RSN1_TM 131 gsnrlwahvvvayiftglvlylly 154
                 +s++++ hv++  i t++ l++++
  EFC39352.1 926 ESQYFIFHVTIEAILTLFLLIVFF 949
                 566777777777777777766654 PP

>> PHM7_cyt  Cytosolic domain of 10TM putative phosphate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.3   1.1   6.7e-09   1.5e-05       2     140 ..     352     513 ..     351     533 .. 0.69

  Alignments for each domain:
  == domain 1  score: 25.3 bits;  conditional E-value: 6.7e-09
    PHM7_cyt   2 rTvlvtgiPkelrse....eklkeffeelypgkv......vesvqivrdvkkldklveerekavrkleaalskykkngkklpkkr...pthklgflglk 87 
                 +T+ + +iPk+++++    + +k++f+++  +        + s   v +++k +kl ++ e  + +le +  +++++ +++pkk+   +++  g  + k
  EFC39352.1 352 FTLEIHNIPKHYTNKalfhQLMKKIFSHNATDLNaptnphILSSYHVINFAKREKLQQKFETQLDNLEGYNWQLETK-NTRPKKKcffQKQDDGDSKRK 449
                 7999**********988877778888776333333332343333455567888899999999999999997655544.445555566644444444556 PP

    PHM7_cyt  88 ligkkvdaidyyrekleeldeeieeerekvkkkp............lgaaFvtfesersaaavak 140
                 li +  dai + +ek+++l+ eie+++e+ + +             +g++ v f+s++s  +++k
  EFC39352.1 450 LI-QSKDAIVFTKEKIRNLNTEIEDLEEELTLSSnypnrisssiqgSGIGYVVFSSRSSIVYALK 513
                 77.556**********************9844332346677777667788888888877766665 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   1.0   4.1e-06    0.0092       8      94 ..      29     120 ..      22     129 .. 0.61
   2 ?   -2.6   0.0       4.9   1.1e+04       4      22 ..     198     217 ..     196     245 .. 0.53
   3 ?   -2.7   0.4       5.3   1.2e+04       4      19 ..     274     289 ..     271     305 .. 0.49
   4 ?   -1.8   0.4       2.9   6.5e+03      72      89 ..     426     441 ..     390     456 .. 0.45
   5 ?   -2.3   5.0         4     9e+03       3      24 ..     592     613 ..     588     630 .. 0.59
   6 ?   -0.8   0.3       1.4   3.2e+03      10      33 ..     817     842 ..     802     873 .. 0.52
   7 ?   -1.1   0.1       1.7   3.7e+03       7      21 ..     939     953 ..     932     992 .. 0.62

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 4.1e-06
     DUF4834   8 lifiiailviglsilsvilrtvfglgsrkkss....ksaqkqfgnstnsnqqksqsrsetkeegeiieeersekeakrk.kiFekdeGEYVd 94 
                 + +i++++v+ + +    + t+f + ++k+      k++++ f ++++++++++++++++++e  ++++++ e+++++k k  +k  +  V+
  EFC39352.1  29 INVILLVIVMSIYVCCIRYCTIFNVRKKKRLIakclKREDELFVEQQSHTRDSENNHNNQEDEIREESNSEREHHESNKgKSLSKTVDQHVE 120
                 33444444455555555566778877776666556677777777777777777776666666555444444455556666888888888776 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 4.9
     DUF4834   4 Llfi.lifiiailviglsil 22 
                 L +i +  ++ +++  + +l
  EFC39352.1 198 LTYIkFHQLLWWVFTIMLVL 217
                 56663333333333322222 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 5.3
     DUF4834   4 Llfilifiiailvigl 19 
                 L +il +i + lv+++
  EFC39352.1 274 LHVILSVITVALVLAM 289
                 3333222222222222 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 2.9
     DUF4834  72 eersekeakrkkiFekde 89 
                 e++++  +++kk F +++
  EFC39352.1 426 ETKNT--RPKKKCFFQKQ 441
                 11111..22333332222 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 4
     DUF4834   3 fLlfilifiiailviglsilsv 24 
                 +  fi+i+ii++++   +++  
  EFC39352.1 592 ITIFIVILIIFVFFTTPVVIVS 613
                 3345555555555555444444 PP

  == domain 6  score: -0.8 bits;  conditional E-value: 1.4
     DUF4834  10 fiiailviglsilsvilrtvfg..lg 33 
                 fi+++ +i +++   + r  +g   +
  EFC39352.1 817 FILLVTFIYFTLRYYVERFTIGriYS 842
                 55555555555555555555553222 PP

  == domain 7  score: -1.1 bits;  conditional E-value: 1.7
     DUF4834   7 ilifiiailviglsi 21 
                 il ++++i+++++ i
  EFC39352.1 939 ILTLFLLIVFFAIEI 953
                 444444444444433 PP

>> DUF4820  Domain of unknown function (DUF4820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   1.5   2.2e-05     0.048     147     227 ..      42     125 ..      29     127 .. 0.58

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.2e-05
     DUF4820 147 iC.srpgrsipvsseldnsartlterksekesaes.seskkrnkee.rdaeseeessedeeeeetvkellekyanenseddsdf 227
                 +C  r  +  +v +++   a+ l+ +++   +++s ++++++n+++ +d+ +ee+ se e++e    + l k ++++ edds+f
  EFC39352.1  42 VCcIRYCTIFNVRKKKRLIAKCLKREDELFVEQQShTRDSENNHNNqEDEIREESNSEREHHESNKGKSLSKTVDQHVEDDSSF 125
                 443555555555555555556665555433333330333333333304444455555555777788889**************9 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   9.3e-05      0.21       7      89 ..       1     114 [.       1     174 [. 0.77
   2 ?   -2.0   0.2       1.5   3.3e+03      58     105 ..     404     471 ..     375     492 .. 0.54

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 9.3e-05
                 TTTTHHHHHHHHHTS--S---SSS---S-EEEEE..............................CCT---CCS...SSEEEET-EB--CHHHHHHHHHH CS
   Dynamin_N   7 qSsGKSSvlnaLlgedilprgpnptTrrplelql..............................geeeeaseravkeelkekekkledfsevreeieke 75 
                 +SsG S ++++L   +++ +g   +T +++++ l                              ++e e   ++++ +  +++ + ++ +e+ree ++e
  EFC39352.1   1 MSSGGSGFIEQLESNPFFKNGGVFVTIAINVILLvivmsiyvcciryctifnvrkkkrliakclKREDELFVEQQSHTRDSENNHNNQEDEIREESNSE 99 
                 69**************************************************99888888888844444344455555555566777777777777777 PP

                 HHHHHT.SSSS--SS CS
   Dynamin_N  76 tekiag.ankgiskk 89 
                 +e +++ ++k+ sk+
  EFC39352.1 100 REHHESnKGKSLSKT 114
                 776664234444433 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.5
                 ET-EB--CHHHHHHHHHHHHHHHTSSSS--SS....................-EEEEEEETTS-SEEE CS
   Dynamin_N  58 kekkledfsevreeieketekiagankgiskk....................villkilsllvkgltl 105
                 +ek +++f+   +++e  + +++++n + +kk                     i++++ ++ + + ++
  EFC39352.1 404 REKLQQKFETQLDNLEGYNWQLETKNTRPKKKcffqkqddgdskrkliqskdAIVFTKEKIRNLNTEI 471
                 44444444444444444444444333333333444444444444444444444455554444444444 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   7.2e-05      0.16      73     166 ..      13     104 ..       3     124 .. 0.44
   2 ?   -3.2   0.1       3.8   8.5e+03      85     105 ..     263     283 ..     231     294 .. 0.50
   3 ?   -1.3   1.6      0.98   2.2e+03      87     104 ..     589     604 ..     555     632 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 7.2e-05
       Shisa  73 gsalevpkdiyvpvlivktifivf..vivgvvvivcccgclkkkqrekrpgrenlssalaev.gpivte..ttsattvvhsrysepqqssssssypgat 166
                 +s+  ++++    ++ ++ ++i++  v+ + v+++  c+++   ++++      + ++l    +  v +  +t ++   h ++ + + ++s+s+  + +
  EFC39352.1  13 ESNPFFKNG--GVFVTIAINVILLviVMSIYVCCIRYCTIFNVRKKKRL-----IAKCLKREdELFVEQqsHTRDSENNHNNQEDEIREESNSEREHHE 104
                 455555533..33344444444440044455555555777654443332.....333333332333332343333333334333444333333333333 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 3.8
       Shisa  85 pvliv.ktifivfvivgvvviv 105
                  ++i+   i+i+ vi+ v+  v
  EFC39352.1 263 NTVIGrPDILILHVILSVIT-V 283
                 34444334555555553222.2 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.98
       Shisa  87 livktifivfvivgvvvi 104
                 ++  tifiv+ i+  +v+
  EFC39352.1 589 ILKITIFIVILII--FVF 604
                 3333444433322..222 PP

>> FAM176  FAM176 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.7   0.00088         2      30      84 ..      27     100 ..      19     129 .. 0.43
   2 ?   -6.0   1.8         8   1.8e+04      28      42 ..     279     293 ..     270     295 .. 0.73
   3 ?    4.7   0.0    0.0094        21      24      57 ..     928     961 ..     916     984 .. 0.68

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00088
      FAM176  30 vcvGLlltLcllviriscrkdle..rlkkkkkklkeeseka.................sededeeeeeeeedss 84 
                 +++  +l ++++ i + c + ++  + +kkk+  ++  +++                 ++++++e  ee++++ 
  EFC39352.1  27 IAINVILLVIVMSIYVCCIRYCTifNVRKKKRLIAKCLKREdelfveqqshtrdsennHNNQEDEIREESNSER 100
                 55555666666666677777776643333333222222222334444333221110001111111111111111 PP

  == domain 2  score: -6.0 bits;  conditional E-value: 8
      FAM176  28 lgvcvGLlltLcllv 42 
                 + + v L+l+++ll 
  EFC39352.1 279 SVITVALVLAMLLLF 293
                 446789999999886 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.0094
      FAM176  24 LlFvlgvcvGLlltLcllviriscrkdlerlkkk 57 
                  +F+  v +  +ltL+ll++  + + +++r+ ++
  EFC39352.1 928 QYFIFHVTIEAILTLFLLIVFFAIEIKMTRDIRT 961
                 499**************99876666665543332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (999 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2218  (0.12371); expected 358.6 (0.02)
Passed bias filter:                      693  (0.0386525); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.04u 0.33s 00:00:01.37 Elapsed: 00:00:00.52
# Mc/sec: 5781.83
//
Query:       EFC39353.1  [L=633]
Description: hypothetical protein NAEGRDRAFT_81315 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0039   17.3   0.0       0.01   15.9   0.0    1.8  1  SAM_2     SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
      0.029   14.6   1.2       0.12   12.7   1.2    2.1  1  Ish1      Putative stress-responsive nuclear envelope protein
      0.035   14.5   0.0      0.075   13.5   0.0    1.6  1  SAM_1     SAM domain (Sterile alpha motif)


Domain annotation for each model (and alignments):
>> SAM_2  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   1.7e-06      0.01       2      65 ..      24      87 ..      23      88 .. 0.93

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.7e-06
                GGHHHHHHHHHHHHTTT..GGGHHHHHHTTCSHHHHHTTSCHHHHHHTTHHHHHHHHHHHHHHHHH CS
       SAM_2  2 eswsledvaeWLrsigl..kqytdnFrdagitgaelllrlteedLkrlGitsvghrkkilkkiqel 65
                + ws+e++ +WL   g+  k ++d   +++++g +++  ++ edL ++Gi      + +l+k+++l
  EFC39353.1 24 KQWSSENLKQWLLDAGYdkKTVVDPIYKQQFDG-SAIIIIKPEDLLDIGIPRGAT-LSLLSKVKDL 87
                57***************99**************.****************77666.9999999998 PP

>> Ish1  Putative stress-responsive nuclear envelope protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   1.2   1.9e-05      0.12       3      20 ..      25      42 ..      23      47 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.9e-05
        Ish1  3 tWSdsdLkkWLdshGipv 20
                 WS ++Lk+WL + G+ +
  EFC39353.1 25 QWSSENLKQWLLDAGYDK 42
                7***********999763 PP

>> SAM_1  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   1.3e-05     0.075       2      63 ..      25      87 ..      24      88 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.3e-05
                CTTHSSHHHHHHHTTS..GGGHHHH.HTTTSSHHHHTTSCHHHHHHCTTTSHHHHHHHHHHHHHH CS
       SAM_1  2 kwsvedVgeWLesigl..gqYadlF.rageidgdaLlllteddLeklgvtllGHrkkIlyaIqrL 63
                +ws e + +WL + g+  +  +d   ++++ dg a+  ++ +dL+++g+ + G  +++l+ +++L
  EFC39353.1 25 QWSSENLKQWLLDAGYdkKTVVDPIyKQQF-DGSAIIIIKPEDLLDIGIPR-GATLSLLSKVKDL 87
                79************9999889999955555.******************99.*******999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (633 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1288  (0.0718389); expected 358.6 (0.02)
Passed bias filter:                      562  (0.0313459); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.48
# Mc/sec: 3936.30
//
Query:       EFC39354.1  [L=583]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-61  207.8   1.0    3.4e-61  207.4   1.0    1.1  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  207.4   1.0   1.9e-65   3.4e-61       2     450 ..      95     551 ..      94     563 .. 0.88

  Alignments for each domain:
  == domain 1  score: 207.4 bits;  conditional E-value: 1.9e-65
                 -SESEHHCCHCHHHHTT.TCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGH.HHHHHH CS
        p450   2 pgptplplvgnllqlgr.keelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfang.ekwkkl 98 
                 pgp+plpl+gnl+q+++ ++++ e+l+ l k+yg++++l + + ++ ++ +p +  e+++k+  e  ++ d++  ++++   +    + +++ e+w ++
  EFC39354.1  95 PGPKPLPLIGNLIQVQTnSKNMSEYLMTLCKQYGDLVKLTVFNFNMLMIANPHLLGELYKKE--ERRNEVDSFRHYKLK-KGQILTPVEMRYdEDWYSI 190
                 8999**********************************************************..566665666666533.4444555666777****** PP

                 HHHHHHHHTSH....STT.THHHHHHHHHHHHHHHHHCCCCHCS..EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSH....HHHHHHHHHHHHHHHHC CS
        p450  99 Rrfltptltsf....gkl.sleelveeeaedlveklrkkagess..elditellskaaldvigsilFgarfdlledek....lselvkaveelssllsk 186
                 R++++ ++         l +l el  + +++l++ l++ +g+ +   ++ +e  s++a+dv++++++g+++    de     + ++ ++v+  ++ ++ 
  EFC39354.1 191 RQLYNIAMKPEyqetITLpQLSELNGDFMRRLIKSLQSVKGSEAfkYVNSSETNSRYAFDVVMKVFLGVKMT---DEVtstlPFDINEFVNYTVHATDV 286
                 *********99877555678888888899999999999999999999**********************965...333233444778888888877744 PP

                 HHHHCCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHCSCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        p450 187 ssvqllllfpllkylptkllrklkeavkklkdlldklieerretldsakksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswa 285
                   v+l   fp++ky  t+ ++ +++ ++k +++++ +i+  + + +++       l  l++++ +k++     de +   ++++l +Gvd t   +  +
  EFC39354.1 287 -AVRLTTKFPMYKYYRTQEYKSFENLMDKSSEYARYCIQRFKTNPSQN-----ARLLELIEER-AKDQ--DRPDERVESVLMQFLQGGVDITVRIMNNC 376
                 .669999999********************************999999.....4566677776.3333..467************************** PP

                 HHHHHHSHHHHHHHHHHHHHHCCTTT..........T-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-T CS
        p450 286 LyeLaknPevqeklreEidevlgdkr..........eptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdp 374
                 ++ La++Pe qek+++E   v+g+ +          ++  ++ +kl+y++ +i E+LRl  + +l++ R++ +d++i+gy+ipk+t+++ +  +    +
  EFC39354.1 377 FHRLAHHPECQEKIYKESVAVFGEPSleevtsedglSINLEQYKKLKYTKHFIDEVLRLNAFGYLTMGRKLDQDTEIGGYMIPKDTMILAMQRWATLKD 475
                 **********************998899************************************************************98877777756 PP

                 TTSSSTTS--GGGGB-TTSCTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSC CS
        p450 375 evfpnPeeFdpeRFldekgnskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileks 450
                 e+ p+ eeF peR ++ +    +++f +lPFG G+R C+G r+A+ el + +++ +++F++  ++  + pp+   +
  EFC39354.1 476 EFVPRGEEFIPERHEKGSPLAPVNNFVSLPFGVGARKCPGSRVATTELLIGIINAVRHFQLCNNNLASFPPSSFDQ 551
                 666***************9999**************************************9888777777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (583 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       827  (0.0461264); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 3473.90
//
Query:       EFC39355.1  [L=580]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-28  100.2   9.7    1.3e-28  100.2   9.7    2.2  2  Nodulin-like  Nodulin-like
    1.3e-27   96.7  31.7    6.5e-15   54.9  13.9    2.1  2  MFS_1         Major Facilitator Superfamily
     0.0063   17.2   0.6       0.46   11.1   0.4    2.5  2  Pex14_N       Peroxisomal membrane anchor protein (Pex14p) co


Domain annotation for each model (and alignments):
>> Nodulin-like  Nodulin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.2   9.7   2.1e-32   1.3e-28       1     185 [.      75     261 ..      75     281 .. 0.92
   2 ?   -2.4   3.1      0.45   2.7e+03      94     157 ..     350     415 ..     343     447 .. 0.51

  Alignments for each domain:
  == domain 1  score: 100.2 bits;  conditional E-value: 2.1e-32
  Nodulin-like   1 rWlvlvaaiwiqsiaGanylFsaySsalKsslgisQkqlnlLavakdlGkalGllsGllaevlplwvvllvgaamglvGYgvvwLvvtesiakl.py 96 
                   rW+ +v    ++ +aG++y Fs++S++lK+   + Q+++n+++ a +lG ++ +l  l+++ l   +  +v+ a+ +  Y+++ L+v++ i+   +y
    EFC39355.1  75 RWIAFVIGAAMMIAAGTQYAFSSISPSLKKRFDLTQTEVNTIGTAANLGTNFSFLFSLVNDFLGARSCSFVSGAFLFGSYFLMALTVSGAIPGAeNY 171
                   8*****999999*******************************************************************************975279 PP

  Nodulin-like  97 wllfllillaanseawlnTaslvtcirnFpe.srgvvvgllkgyaGlsaaiytqlyeailgsdaksllllvalvplvvslvvlylvreve 185
                   ++l  ++++ +ns   + Ta++ t+++nFpe +rg+vvg+l ++ G+s+aiy+  y+ i++ + + ++++ a++  +v+l++  + +  +
    EFC39355.1 172 IALSAFMFIMGNSSGGAYTAAMTTSVKNFPErNRGLVVGVLASFFGISSAIYSGSYQYIFQLQLQPYMIFCAVLGGIVVLILGTVFLDGK 261
                   9****************************9659*********************************************998866665554 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.45
  Nodulin-like  94 lpywllfllill.aanseawl.nTaslvtcirnFpesrgvvvgllkgyaGlsaaiytqlyeailgs 157
                   l +wl fl+i++  + +++ + n +slv++   ++  + ++v +    + l+  ++  l   +l+ 
    EFC39355.1 350 LDFWLAFLVIFIvVGSGITVInNLGSLVLAYGGYNGQQNMMVIVFSICNCLGRLLFGILSDKLLSP 415
                   667776666543134555554145777777766666666666555555555555555555544443 PP

>> MFS_1  Major Facilitator Superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   54.9  13.9   1.1e-18   6.5e-15       4     222 ..      83     362 ..      77     370 .. 0.72
   2 !   43.7  15.9   2.8e-15   1.7e-11       3     171 ..     357     542 ..     345     553 .. 0.84

  Alignments for each domain:
  == domain 1  score: 54.9 bits;  conditional E-value: 1.1e-18
       MFS_1   4 aaflsalarsilgpalplalaedlgispseigllltlyalgaavaslplGrlsdrfGrrr.vlllglllfalglllll.fa......sslwlllvlrvl 94 
                 aa+++a++   +++++++ l++ + ++ +e++++ t+  lg+  +s++++ + d +G+r+  ++ g++lf++ +l++l ++       ++ +l ++ ++
  EFC39355.1  83 AAMMIAAGTQYAFSSISPSLKKRFDLTQTEVNTIGTAANLGT-NFSFLFSLVNDFLGARScSFVSGAFLFGSYFLMALtVSgaipgaENYIALSAFMFI 180
                 344444444445555555*******************99965.5788999***********************5555544244667455559******* PP

       MFS_1  95 qGlgagalfpagaaliadwfpkeergraigllsagfslGailgpllggllasslgWravfyilaivsllafv.lfllllpeepperkrkspkeee.... 188
                 +G  +g++++a+++  ++ fp+++rg+++g+l+++f++++++  +   ++  +l  +  ++++a+++ ++++ l+ ++l  + ++ k++++k+ +    
  EFC39355.1 181 MGNSSGGAYTAAMTTSVKNFPERNRGLVVGVLASFFGISSAIYSGSYQYIF-QLQLQPYMIFCAVLGGIVVLiLGTVFLDGKSSADKNDAGKKVStant 278
                 **********************************************99**9.9999*************988455555544444444444444437777 PP

       MFS_1 189 .......................................................kgtgpaplvpawkallkdpvlwillialllfffg 222
                                                                        ++ +  ++   +k+l +      +++a+l++f++
  EFC39355.1 279 inssqqeatttseegkpivvdpstgelpaeqtlesttmmeedtqtyeedelreklQQLEIPNVN-SLKMLISLD----FWLAFLVIFIV 362
                 7777777777777777777777777777777777777777777777555554442222222222.355555555....44444444433 PP

  == domain 2  score: 43.7 bits;  conditional E-value: 2.8e-15
       MFS_1   3 laaflsalarsilgpalplalaedlgispseigllltlyalgaavaslplGrlsdr.fGrrr.vlllglllfalg.lllll..fa.sslwlllvlrvlq 95 
                 l++f++  +  +++ +l   l  ++g    ++++++ ++++  +++ l++G lsd+ ++++r +  +++l+ ++  ++++   fa  +l  ++ l ++ 
  EFC39355.1 357 LVIFIVVGSGITVINNLG-SLVLAYGGYNGQQNMMVIVFSICNCLGRLLFGILSDKlLSPKRgITRITFLSICIVmMTVIQflFAvMPLEGFYPLIIFL 454
                 333333333333444444.8999999999***************************88999999999999999995555554334444446******** PP

       MFS_1  96 GlgagalfpagaaliadwfpkeergraigllsagfslGa.ilgpllgglla.sslg..............Wravfyilaivsllafvlflll 171
                 G+++g+ +++  ++ ++ f  +  g+   + s+++slG+ ++  +l+g+l+    +              ++a+fyil +++++a+++   l
  EFC39355.1 455 GICYGGTYALTPTFNSERFGAKYFGMNSTIQSMAASLGSyAFSTGLAGYLYqV--NiekprtltchgrpcYEATFYILSLLGCVALII--SL 542
                 ***************************************9***********44..456***************************886..33 PP

>> Pex14_N  Peroxisomal membrane anchor protein (Pex14p) conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   0.4   7.6e-05      0.46      66     150 ..      12      96 ..       1     102 [. 0.48
   2 ?    3.5   0.0     0.017     1e+02      59     145 ..     275     367 ..     257     373 .. 0.38

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 7.6e-05
     Pex14_N  66 aqeesasssatpqpqaasqtsqsspsps...ppaqqqqqqyrpPivtypefltkppkppppPlrtwrdlli.tatalaglgaglyglsk 150
                 ++++s++ +a  +++++s+++++s++ +   + ++  ++q +p iv + +f +     +   lr++r+++  +++a++ ++ag+ ++++
  EFC39355.1  12 SSSTSNQHAAADHEESSSYNNNTSTP-TlieEDYGVYKKQRHPIIVKFLQFKQ---FYQSEKLRKVRRWIAfVIGAAMMIAAGTQYAFS 96 
                 22222333333333333333332222.23445666666666666666655554...444566888888887455666666666666655 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.017
     Pex14_N  59 assaseqaqeesasssatpqpqaasqtsqsspspsppaqqqqqqyrpPivtypefltk.ppkppppPlr.......twrdllitatalaglgagl 145
                 ++++ +++q+e +++s++ +p    +++   + p++++ ++++ + +  +ty+e   +   ++ + P +       ++  +l  ++++  +g+g+
  EFC39355.1 275 TANTINSSQQEATTTSEEGKPIVVDPSTG--ELPAEQTLESTTMMEEDTQTYEEDELReKLQQLEIPNVnslkmliSLDFWLAFLVIFIVVGSGI 367
                 11111111111111121122211111111..1111222222222255666776654443333346666656666665555555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (580 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1111  (0.0619666); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.34s 00:00:01.08 Elapsed: 00:00:00.53
# Mc/sec: 3299.74
//
Query:       EFC39356.1  [L=378]
Description: hypothetical protein NAEGRDRAFT_81320 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       765  (0.0426683); expected 358.6 (0.02)
Passed bias filter:                      509  (0.0283898); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.57
# Mc/sec: 1994.85
//
Query:       EFC39357.1  [L=555]
Description: hypothetical protein NAEGRDRAFT_81322 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    5.8e-16   57.9  24.2    1.3e-05   24.8   1.8    6.2  8  DUF4116    Domain of unknown function (DUF4116)
    0.00091   19.6   0.0     0.0023   18.4   0.0    1.8  1  SMI1_KNR4  SMI1 / KNR4 family (SUKH-1)
     0.0058   16.4   0.2       0.03   14.1   0.0    2.3  2  SUKH_5     SMI1-KNR4 cell-wall


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1         1   6.2e+03      11      24 ..     191     204 ..     190     205 .. 0.82
   2 !   19.4   0.2   1.1e-07   0.00064      12      49 .]     213     250 ..     206     250 .. 0.89
   3 !   23.6   0.4   5.2e-09   3.1e-05       1      49 []     252     300 ..     252     300 .. 0.97
   4 !    8.3   0.4   0.00031       1.8       8      48 ..     284     324 ..     283     344 .. 0.84
   5 ?    2.2   0.3     0.026   1.6e+02       1      15 [.     301     324 ..     301     359 .. 0.58
   6 !   19.1   0.8   1.3e-07   0.00079      15      48 ..     417     450 ..     399     450 .. 0.84
   7 !   24.8   1.8   2.2e-09   1.3e-05       1      33 [.     428     460 ..     428     472 .. 0.94
   8 ?   -3.1   0.0       1.1   6.8e+03      26      37 ..     481     492 ..     480     498 .. 0.60

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1
     DUF4116  11 kngsalkylseeLk 24 
                  n++  ++lse+++
  EFC39357.1 191 YNPFDMEKLSENFS 204
                 58999999999985 PP

  == domain 2  score: 19.4 bits;  conditional E-value: 1.1e-07
     DUF4116  12 ngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++ +l  l++++knD e+++k v  n+ a+ y++e +r
  EFC39357.1 213 HSDILSCLPDKFKNDLELMKKLVVANPEAFGYMPEIIR 250
                 5668999****************99**********987 PP

  == domain 3  score: 23.6 bits;  conditional E-value: 5.2e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D  ++ e++ + + +++ +s++Lk+Dke+   A+  + t++++a+++L+
  EFC39357.1 252 DINFIRELIMRRPRIYRSVSDRLKKDKELFDLACSLDITNFYHAHHSLK 300
                 789*******************************************997 PP

  == domain 4  score: 8.3 bits;  conditional E-value: 0.00031
     DUF4116   8 avkkngsalkylseeLknDkeivlkAvkqngt.alsyaseeL 48 
                 a++ +  +++++ ++Lk Dke++lk +k + + + + +++eL
  EFC39357.1 284 ACSLDITNFYHAHHSLK-DKELALKYCKLSRYlSANDFPDEL 324
                 6777777999******9.**********88854667777665 PP

  == domain 5  score: 2.2 bits;  conditional E-value: 0.026
     DUF4116   1 DrEivleavkkngs.........a 15 
                 D+E++l+++k   +          
  EFC39357.1 301 DKELALKYCKLSRYlsandfpdeL 324
                 677777776644222333333330 PP

  == domain 6  score: 19.1 bits;  conditional E-value: 1.3e-07
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 a++ l+e Lk+D++++++A+k+  ++++ +seeL
  EFC39357.1 417 AFNVLPEHLKKDIDVIKAAIKKRFNIFKILSEEL 450
                 66679***************************98 PP

  == domain 7  score: 24.8 bits;  conditional E-value: 2.2e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkA 33 
                 D ++++ a+kk  +++k lseeLk+D++++l +
  EFC39357.1 428 DIDVIKAAIKKRFNIFKILSEELKQDRDFILYC 460
                 89*****************************98 PP

  == domain 8  score: -3.1 bits;  conditional E-value: 1.1
     DUF4116  26 DkeivlkAvkqn 37 
                 D e++  A+++ 
  EFC39357.1 481 DLEFLEIACNNT 492
                 556666665544 PP

>> SMI1_KNR4  SMI1 / KNR4 family (SUKH-1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   3.8e-07    0.0023       2      51 ..      77     127 ..      76     226 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 3.8e-07
                 --HHHHHHHHHHHTS---HHHHHHHHHHTS..EEEEETT..SEEETTEEEEEE- CS
   SMI1_KNR4   2 ateedlqefekdlgikLPndyreflkltnG..gelfges..nglifglkllsld 51 
                 + eed+q +e+++g k+P  +ref+k+++G  +    +    +l + ++l +++
  EFC39357.1  77 VREEDIQLVEERMGQKFPFHLREFIKIIDGrpA---HSQdlTNLHYTNSLRPFK 127
                 789***************************532...222223555555555544 PP

>> SUKH_5  SMI1-KNR4 cell-wall
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.0     5e-06      0.03      16      46 ..      74     104 ..      51     124 .. 0.81
   2 ?   -1.6   0.0      0.34     2e+03      22      58 ..     207     243 ..     180     254 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 5e-06
                 ..---HHHHHHHHHHHTS---HHHHHHHHHC CS
      SUKH_5  16 lvlpddeeikeaEekLgikfpneykeFlkey 46 
                  +++ +e+i+ +Ee +g kfp  ++eF+k +
  EFC39357.1  74 SQGVREEDIQLVEERMGQKFPFHLREFIKII 104
                 34899***********************976 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.34
                 HHHHHHHHHHTS---HHHHHHHHHC-SEEETTEEE-S CS
      SUKH_5  22 eeikeaEekLgikfpneykeFlkeygdggiggleilg 58 
                  +i +++  ++  +p+++k  l+ + + ++   e +g
  EFC39357.1 207 VKISRYHSDILSCLPDKFKNDLELMKKLVVANPEAFG 243
                 5677888888888888888888877777776655555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       530  (0.029561); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 3210.92
//
Query:       EFC39358.1  [L=610]
Description: PX-domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.6e-08   33.8   1.2      6e-08   32.7   1.2    1.6  1  PX        PX domain
  ------ inclusion threshold ------
      0.027   14.4   0.0      0.054   13.4   0.0    1.5  1  F-box     F-box domain
        7.4    7.2   8.7       0.41   11.2   1.1    2.8  3  DUF2482   Hypothetical protein of unknown function (DUF2482)


Domain annotation for each model (and alignments):
>> PX  PX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.7   1.2     1e-11     6e-08      15     112 ..     492     600 ..     485     601 .. 0.90

  Alignments for each domain:
  == domain 1  score: 32.7 bits;  conditional E-value: 1e-11
                 TTSSEEEEEEEEEETTS..SSEEEEEEEHHHHHHHHHHHHHHHT.......TSTSTSSSTSGSSSSS.CTTSHHHHHHHHHHHHHHHHHHHTSCHHHH. CS
          PX  15 gskkhsyylyevelktg..akewtvkRrYsdFeeLhskLlrkfp.......rvkiPplPkkvlfgsv.rkkdeefiekrrkgLeeyLqrllnhpelrn. 102
                  +k++ yyl+ +++k +    + t+k+rYs+Fe+L +++    +       + ++  +P k +++s     ++++iekr++ +++ L +l+n+    + 
  EFC39358.1 492 ENKHSVYYLIDITMKIEesTYTYTLKKRYSQFEKLFQRMCAVRKtdkivgkNGEVLIFPYKEIIDSLlGTRSKDIIEKRKELFNKILFELVNNLDEYKd 590
                 578899999999999888899******************988888899999889999999999986698999**************************9 PP

                 SHHHHHHHHS CS
          PX 103 sevlteFLev 112
                 +e++  F++ 
  EFC39358.1 591 DEEIMVFFTD 600
                 *******986 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   9.1e-06     0.054      20      40 ..     285     305 ..     284     312 .. 0.91

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 9.1e-06
                 HHHHHHHCTT-HHHHHHHTTH CS
       F-box  20 lsdllalrrVSkgwrilidsd 40 
                 l+++l+lr+V k+w++ id++
  EFC39358.1 285 LKSILRLRLVNKKWKQSIDNP 305
                 689***************986 PP

>> DUF2482  Hypothetical protein of unknown function (DUF2482)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0         3   1.8e+04       5      16 ..     275     286 ..     268     294 .. 0.64
   2 ?   11.2   1.1   6.8e-05      0.41       4      80 ..     430     503 ..     427     525 .. 0.75
   3 ?   -0.8   0.2      0.37   2.2e+03      19      34 ..     575     590 ..     554     602 .. 0.63

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 3
     DUF2482   5 dmtqeeikdlla 16 
                 dm+ ++i ++l+
  EFC39358.1 275 DMKTNDIANMLK 286
                 555555555554 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 6.8e-05
     DUF2482   4 KdmtqeeikdllaeKskeLyelieeikeetdFdillfsai.gvsdgdaqvsssslvvGkivglanlLkneeefkdivn 80 
                 K   ++ei++ ++eK+k L     ++ + t+F+ +++ +  g++ +        + +G i+++a++ +++  +  i  
  EFC39358.1 430 KKSAEKEIIQTVEEKEKALDSFRMKMRKITQFENMVIEKYeGIQAQG----NDASWTGYIFSFASMENKHSVYYLIDI 503
                 556789***************************99998876888776....456679********8888877753322 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.37
     DUF2482  19 skeLyelieeikeetd 34 
                 +k L+el+++++e  d
  EFC39358.1 575 NKILFELVNNLDEYKD 590
                 3346677777777543 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (610 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1022  (0.0570026); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 3588.81
//
Query:       EFC39359.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
     0.0031   17.8   0.2     0.0053   17.0   0.2    1.4  1  Shisa          Wnt and FGF inhibitory regulator
  ------ inclusion threshold ------
      0.038   13.2   0.0      0.076   12.2   0.0    1.4  1  Peptidase_M56  BlaR1 peptidase M56
      0.062   14.2   0.1       0.22   12.4   0.0    1.9  2  EphA2_TM       Ephrin type-A receptor 2 transmembrane domain


Domain annotation for each model (and alignments):
>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.2   8.9e-07    0.0053      61     164 ..     209     301 ..     186     323 .. 0.48

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 8.9e-07
       Shisa  61 lktgreekekqlgsalevpkd...iyvpvlivktifivfvivgvvvivcccgclkkkqrekr........pgrenlssalaev...gpivtettsattv 145
                  +t++++++k+         d   +y +v  ++  f+++++v +  +vc+  c+kk   +++        p + ++ss + e+   +pi  +       
  EFC39359.1 209 HNTNENQYDKM---------DssfTYGMVGGIVGFFVLLIVVTAASLVCVHFCMKKQFFKEKkkpkdrenPDEVPVSSNKEETqrnKPISES------- 291
                 22222222222.........123356667777889999988877777777777766555444233333444444444444444222232222....... PP

       Shisa 146 vhsrysepqqssssssypg 164
                          ++++  ++p+
  EFC39359.1 292 ---------KPKVKYENPT 301
                 .........2222222222 PP

>> Peptidase_M56  BlaR1 peptidase M56
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   1.3e-05     0.076      58     164 ..     181     290 ..     166     297 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.3e-05
  Peptidase_M56  58 vkfetskinsaaskaplasaaskvlddkas...alatdvkkvewktilkillliWivgalilllyliaallvlkkrfvrklgklraeelkeaLkea 150
                      ++ s+  + ++ + ++s +sk+ d++ +   ++  ++ ++ +  ++  ++  ++++++++++ l+ + + +kk+f+++++k ++ e  +++   
     EFC39359.1 181 NMSNLSPNTEFQPMVSINSFVSKDCDSSHNtneNQYDKMDSSFTYGMVGGIVGFFVLLIVVTAASLVCVHFCMKKQFFKEKKKPKDRENPDEVPVS 276
                    3333444444555555666666666666664445555566666666667777788999999999999999999999***99999999999999988 PP

  Peptidase_M56 151 keemqlkrnikirl 164
                    +++ + +rn  i+ 
     EFC39359.1 277 SNKEETQRNKPISE 290
                    88888888877765 PP

>> EphA2_TM  Ephrin type-A receptor 2 transmembrane domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.1   6.6e+03      16      29 ..       2      15 ..       1      39 [. 0.56
   2 ?   12.4   0.0   3.7e-05      0.22       5      56 ..     231     297 ..     227     313 .. 0.39

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.1
    EphA2_TM 16 vilvlvlvrrrskn 29
                v++++++ + ++++
  EFC39359.1  2 VVIFMLISSTQCQK 15
                33333433332222 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 3.7e-05
    EphA2_TM   5 avaglvllvilvilvlvlvrrrsknrkqksdl.....k..........skeekkeeensgkk.glktY 56 
                 +v+ +vll+++ +  lv+v+ + k++  k+++     +          ++e++++++ s++k ++k Y
  EFC39359.1 231 IVGFFVLLIVVTAASLVCVHFCMKKQFFKEKKkpkdrEnpdevpvssnKEETQRNKPISESKpKVK-Y 297
                 444444444444445555544444443333333445515555555333222222222222222222.3 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       982  (0.0547716); expected 358.6 (0.02)
Passed bias filter:                      507  (0.0282782); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2048.39
//
Query:       EFC39360.1  [L=530]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.9e-09   37.2   0.1    4.2e-09   36.1   0.1    1.6  1  KH_1        KH domain
  ------ inclusion threshold ------
       0.05   12.9   0.1       0.11   11.9   0.1    1.5  1  LETM1       LETM1-like protein


Domain annotation for each model (and alignments):
>> KH_1  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.1   0.1   4.7e-13   4.2e-09       9      65 ..     262     330 ..     248     331 .. 0.82

  Alignments for each domain:
  == domain 1  score: 36.1 bits;  conditional E-value: 4.7e-13
                 GHHHHHHTGGGHHHHHHHHHHT-EEEEES.STT.............T.-EEEEEE.SHHHHHHHHHHHH CS
        KH_1   9 slvgriIGkgGsnIkeIreetgakIkvpk.sedeg..........sderevtisG.speavekAkelie 65 
                 +++g+iIG+gG + k++++e+gakI v + ++  +          +++  v i+  ++++vekA+e+i+
  EFC39360.1 262 NFIGLIIGPGGLTQKKLEKESGAKIAVRGkGSVKPgkiptksfadEENLHVLITAdDEDSVEKAAEMIK 330
                 45************************99544444479******7777777777**************96 PP

>> LETM1  LETM1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   1.2e-05      0.11     214     244 ..     337     367 ..     321     370 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 1.2e-05
       LETM1 214 reGvdsLseeeLqeacrsRGlraaglseeel 244
                 +eG ++L++e+L+e++r+RG+ ++g+s++el
  EFC39360.1 337 EEGSNELKKEQLRELARQRGFTIEGMSDAEL 367
                 47*************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (530 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1577  (0.0879581); expected 358.6 (0.02)
Passed bias filter:                      566  (0.031569); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.30s 00:00:01.07 Elapsed: 00:00:00.52
# Mc/sec: 3085.49
//
Query:       EFC39361.1  [L=416]
Description: hypothetical protein NAEGRDRAFT_59290 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.021   14.7   0.2      0.066   13.1   0.0    1.9  2  PB1              PB1 domain
       0.83    8.9  26.6        1.1    8.5  26.6    1.1  1  BUD22            BUD22


Domain annotation for each model (and alignments):
>> PB1  PB1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   7.4e-06     0.066      23      79 ..      83     135 ..      63     139 .. 0.73
   2 ?   -3.8   0.0       1.5   1.3e+04      20      34 ..     214     228 ..     210     235 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 7.4e-06
                 -HHHHHHHHHHHHTSTCCSEEEEEEETTSSEEEESSHHHHHHHHHHHHHTSSCCEEE CS
         PB1  23 sfeeLrakvekrfklsdedvklkYpdedgdlVtitsDeDLeealeearslksktlrl 79 
                 s++ +++ +++   +  ++ k  Y d+++dlV ++++ D++ +l+  ++   + +++
  EFC39361.1  83 SLQGFLNVLKSNGIS-AQSHKFYYVDDEQDLVVLSTEYDFKYMLKILKG---NAIKI 135
                 555555555554444.4888999*********************99865...45555 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 1.5
                 SSS-HHHHHHHHHHH CS
         PB1  20 snisfeeLrakvekr 34 
                 ++i+++eL+++ +k+
  EFC39361.1 214 RTIRLSELLKNAQKE 228
                 678899998876665 PP

>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  26.6   0.00013       1.1      99     279 ..     178     372 ..     157     396 .. 0.45

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.00013
       BUD22  99 eelektkalenvtsrLlnsktvkevveeivesvkkllgiekkkkkkeeekkkkkkkkkkkkkkeeee.............eeesdkeeesedsed...e 181
                 ee   ++al+ v s ++ +k+ + + ++   + ++++ i+ ++  k+++k+k++ kk++k++++ e+             +   ++e e++++e+   e
  EFC39361.1 178 EEHLIEQALDSVFSGIFEKKQERPQPNNSQFNTQRVRTIRLSELLKNAQKEKQE-KKEEKQTRSFEDylaelfgkklaerR---NQEGEQAKKEEskvE 272
                 444455667777777777777776666666666666666661111222222222.22222222222267788999996541...333333333332344 PP

       BUD22 182 ekeeseddeeeeeededdedaeedeedeeaeerelaqydglla...sddeded....eyneetdeesseesdssdssesasesesessekkkkkkkkkk 273
                 ek+  ++++e++ e++++e +ee ++ ee+++  + +  ++++    +de+ed    e++ ++d++ss +s++ +++e + +  s ++e+    +++  
  EFC39361.1 273 EKSVPQQQQESTVEEKKEELKEE-SQPEEKKDTPFLSTSQIISnylIEDEEEDivtdEDDYDSDDQSSVASEQVNQTEVQYPTISAEEES----SNTIP 366
                 44444444444444444444443.333344444444444433346766666663333222233333333333333333322222222222....22222 PP

       BUD22 274 kkakak 279
                 ++++++
  EFC39361.1 367 ETSNEE 372
                 222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3028  (0.168888); expected 358.6 (0.02)
Passed bias filter:                      655  (0.036533); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.81u 0.34s 00:00:01.15 Elapsed: 00:00:00.51
# Mc/sec: 2464.59
//
Query:       EFC39362.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      7e-11   42.3   0.3    1.3e-10   41.4   0.3    1.5  1  Pan3_PK      Pan3 Pseudokinase domain
    2.2e-06   27.2   0.0    1.1e-05   25.0   0.0    1.9  2  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
      0.032   13.5   0.0       0.11   11.7   0.0    1.8  2  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pan3_PK  Pan3 Pseudokinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.4   0.3   2.2e-14   1.3e-10       2      53 ..     304     355 ..     303     356 .] 0.95

  Alignments for each domain:
  == domain 1  score: 41.4 bits;  conditional E-value: 2.2e-14
     Pan3_PK   2 eellkaiaerlleeldsaleesdlleselskelengrlvrlllklgfinerp 53 
                 ++l+++ia r+++el +++++ d++e+el+kelengrl+rll+kl+f+ +++
  EFC39362.1 304 NKLISNIALRYVDELSTMYNYVDTIENELAKELENGRLFRLLVKLNFVAQHE 355
                 68999*******************************************9876 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.0   1.8e-09   1.1e-05      12     124 ..      87     205 ..      86     239 .. 0.86
   2 ?   -0.2   0.0     0.085   5.1e+02     233     248 ..     254     300 ..     205     303 .. 0.61

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 1.8e-09
                 SEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.....SSEEEEEEE--TTEB.HHHHHH..HHSS--HHHHHH CS
     Pkinase  12 fGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.....kdelylvleyvegge.ladlle..rkgslseeeakk 102
                 fG+ ++++++++    ++ +i+++++ + ++  +l+      k+khpniv l++v+++     +++l+++ +y +g e l+++    ++++ +e+++ +
  EFC39362.1  87 FGQSFRVIDSASASPCCLRRISEHQILSIEQ--ALTSADPWFKIKHPNIVSLKQVISTdqfgnDNDLLFIYDYSPGAEtLEEHFFieTSRAPAESTLWS 183
                 8999999999999999999999999999876..99999999***************9999999999*********99875554333388889999**** PP

                 HHHHHHHHHHHHHHTTEE-SS- CS
     Pkinase 103 iakqilegleylHskgiiHrDl 124
                 ++ q l++l+ +Hsk++ +r  
  EFC39362.1 184 LICQCLSALREIHSKNLAYRTF 205
                 *******************965 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.085
                 S...............................-HHHHHHHHHHT-SS CS
     Pkinase 233 i...............................seeakdllkkllkkd 248
                 +                               s e+ d++k ll+ d
  EFC39362.1 254 LlvelmctfrelsdaphalsvlnnsesisckySTELVDFVKTLLQDD 300
                 03333333333333344444445555556666999999999999876 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   1.9e-05      0.11      48     159 ..     118     238 ..      95     267 .. 0.80
   2 ?   -0.2   0.0     0.079   4.7e+02     183     201 ..     243     261 ..     235     288 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.9e-05
                  HHHHHHHHHTS-BTTB--EEEEEE.....SSSSEEEEEE--TTE.BHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE. CS
  Pkinase_Tyr  48 lleeakimkklkhpnivkllgvct.....keepllivteyvkgG.dLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse. 138
                   l+ a+   k+khpniv+l  v++     +++ ll++ +y +g  +L+++   +++++   ++l s++ q  ++++ ++sk+l  r   +  +++   
   EFC39362.1 118 ALTSADPWFKIKHPNIVSLKQVIStdqfgNDNDLLFIYDYSPGAeTLEEHFFIETSRAPAESTLWSLICQCLSALREIHSKNLAYRTFYTNKIIILPg 215
                  55556666799************9777766677********99857887766666999999***************************9999998754 PP

                  ..TTEEEE-STTTHEETTTSSEE CS
  Pkinase_Tyr 139 ..nkvvkisDfGLardiekddey 159
                    nk  k+   G+ + +e+++e 
   EFC39362.1 216 ltNKRFKLNCSGMLDILENTEEA 238
                  44777888777777777666655 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.079
                  EHHHHHHHHHHHHHHHHTT CS
  Pkinase_Tyr 183 tsksDvWsfGvllwEiftl 201
                  ++k D   fG+ll E++++
   EFC39362.1 243 QQKEDFKHFGILLVELMCT 261
                  56778889********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       486  (0.0271069); expected 358.6 (0.02)
Passed bias filter:                      345  (0.0192426); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.43
# Mc/sec: 2502.24
//
Query:       EFC39363.1  [L=347]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.4e-70  235.8   9.8      1e-69  235.7   9.8    1.0  1  Serpin    Serpin (serine protease inhibitor)


Domain annotation for each model (and alignments):
>> Serpin  Serpin (serine protease inhibitor)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  235.7   9.8   5.7e-74     1e-69      50     370 ..      15     342 ..       1     343 [. 0.89

  Alignments for each domain:
  == domain 1  score: 235.7 bits;  conditional E-value: 5.7e-74
                 HHHHTGCCHCHHHHHHHHHHHHHHHCS..SGGTSEEEEEEEEEEEETTSEB-HHHHHHHHHHHS-EEEEE-TTTHHH.HHHHHHHHHHHHTTTSSSSSS CS
      Serpin  50 levLglnesdeeelhealekllsrlne..seekdkelkianglfvekglklkeeflklakklykaevesvdfkddee.arkkINswvekqTngkIkdll 145
                 l+ +g+    e++++  +e++++++n   +++ +++l+++n++f++++++l e++ +l+++ ++a+v s df++++e    kIN++v++ T+g+I++++
  EFC39363.1  15 LDYFGI---IEKDVKPMMEQMMKSFNIenDDDCGTTLSMVNSIFLSDQFTLLESYHSLVNQTFNAKVDSCDFVNNQEgEIAKINKFVSDFTKGMIQNIV 110
                 444444...34556677888888888776678899**************************************************************** PP

                 STTSS-TTECEEEEEEEEEEEEBSS--BGGGEEEEEEE.SSSSEEEEEEEE.EEEEEEEE.....EEETTTTEEEEEEEBGGSEEEEEEEESSTTTHHH CS
      Serpin 146 segsidsdtrlvlvNaiyFkGkWeepFqpeatreekFy.vnegekvkvpmM.sqegkfky.....aedeelnakvlelpYkgnlsmlillPdeekglee 237
                 + + i+++tr+v +N iyF ++W+++F+p++t++++F+ ++ +++v+++mM +++ ++ y     +ede+ ++  ++lpY+++ sm+i++P ++++ ++
  EFC39363.1 111 DCNFIQKTTRIVSLNGIYFAAQWKDQFDPSETKKKPFFtCDGSDSVSIEMMiKKDTRVLYgnddpDEDENPQYHWIKLPYRSEHSMIIIMPMDKTEEND 209
                 **************************************45555556*****98888999999999899999********************55666666 PP

                 HHHHHSHHHHHHHHHHGEEEEEEE.EEEEE-EEEEEEEEHHHHHHH..TTHCGGGSTTTB.BTTTBSSSSEEEEEEEEEEEEEESSSEEEEEEEEEECC CS
      Serpin 238 lekkltaerleewlsklkmkkeke.evslPkfkieesidlkevLqk..lGlkdlFseneadlsgiskkeplfvsevlhkafievnEeGteaaaatavat 333
                 + +k   e+le++    +++  +  ++slPk+ki+e+++l++v+++  +++k++Fs ++a+++++++++ l +++++h+++ie+nEeGt+a+a t ++ 
  EFC39363.1 210 VFDKWIVEKLERMYYFSTES-ITMdRLSLPKMKIKEKVNLNDVFKSepFNMKSMFS-ENANFERMIQNDHLPITDIFHECVIEINEEGTKASAIT-IKG 305
                 66666669999977776655.44449******************97559*******.*********99***************************.888 PP

                 TTCS-SSCEEEEECSEEEEEEEETTTTEEEEEEEESS CS
      Serpin 334 llskksspvefkvdrPFlflireektgliLFlGkvvn 370
                   ++ +s++ f v+rPF++li e+ t+ +LF+ k++n
  EFC39363.1 306 RGKSAKSKFYFDVNRPFVMLITENCTQQVLFISKINN 342
                 99999*****************************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      290  (0.0161749); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 1996.95
//
Query:       EFC39364.1  [L=399]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.8e-12   44.9  10.7    0.00013   21.6   0.0    5.8  7  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
     0.0018   18.9   8.5       0.25   12.0   0.5    4.4  5  RCC1      Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.026   13.9   0.0       0.92    8.8   0.0    2.1  2  PHTB1_N   PTHB1 N-terminus


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.017     1e+02       1      28 [.      10      37 ..      10      38 .. 0.90
   2 ?   -4.2   0.5       2.8   1.7e+04      24      29 ..      67      72 ..      63      72 .. 0.80
   3 !   14.9   0.1   2.8e-06     0.017       4      30 .]      89     115 ..      86     115 .. 0.91
   4 !   21.6   0.0   2.2e-08   0.00013       1      26 [.     148     173 ..     148     177 .. 0.93
   5 !    6.8   0.2     0.001       6.1       1      28 [.     201     228 ..     201     229 .. 0.92
   6 ?    0.7   0.2     0.083     5e+02      22      28 ..     270     276 ..     257     278 .. 0.84
   7 ?   -3.3   0.0       1.5   8.8e+03      11      21 ..     303     313 ..     299     313 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.017
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWGsNsd 28
                +k vs G +    Lt dG++l  G+N++
  EFC39364.1 10 IKEVSTGKDYMTLLTMDGRLLFMGQNTF 37
                6779999999999************985 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 2.8
      RCC1_2 24 GsNsdG 29
                G+N++G
  EFC39364.1 67 GDNGVG 72
                899988 PP

  == domain 3  score: 14.9 bits;  conditional E-value: 2.8e-06
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 v +G y+ ++Lt+d ++ + GsN++GQ
  EFC39364.1  89 VGSGMYFMVVLTSDYRLISSGSNECGQ 115
                 667889********************9 PP

  == domain 4  score: 21.6 bits;  conditional E-value: 2.2e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsN 26 
                 ++++++G+ H ++Lt+dG++ ++G+ 
  EFC39364.1 148 IVKIACGYQHCMILTRDGTMIGTGCS 173
                 799*********************85 PP

  == domain 5  score: 6.8 bits;  conditional E-value: 0.001
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsd 28 
                 ++++ +G++ s  ++++G V+  G++s+
  EFC39364.1 201 IVDIQCGYFSSSCIDANGMVYVVGQESY 228
                 799*****99888***********9986 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.083
      RCC1_2  22 cWGsNsd 28 
                  WGsN+d
  EFC39364.1 270 NWGSNDD 276
                 5****87 PP

  == domain 7  score: -3.3 bits;  conditional E-value: 1.5
      RCC1_2  11 scaLtedGeVl 21 
                 ++a+te+ +++
  EFC39364.1 303 FLAVTESKDIY 313
                 799**998876 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.67     4e+03       1      12 [.      26      37 ..      26      67 .. 0.75
   2 !   12.0   0.5   4.1e-05      0.25       8      50 .]     109     161 ..     104     161 .. 0.55
   3 !    9.1   0.0   0.00034         2       2      50 .]     165     214 ..     164     214 .. 0.68
   4 ?   -2.6   0.0       1.6   9.3e+03       1      15 [.     217     231 ..     217     231 .. 0.82
   5 ?   -2.4   0.2       1.3     8e+03       6      12 ..     270     276 ..     265     278 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.67
                TTEEEEEE--GG CS
        RCC1  1 dGrVysWGrndy 12
                dGr++  G+n++
  EFC39364.1 26 DGRLLFMGQNTF 37
                788988898864 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 4.1e-05
                 E--GGGTTSSSS-........--E.EEEEE-GGGTTS...-EEEEEEETTEEEEE CS
        RCC1   8 GrndyGqLGlgtt........esv.lvPtkveglsgn...rvvkvacGddhtval 50 
                 G+n+ Gq G g++        e+v +  + ++ ++++    +vk+acG++h++ l
  EFC39364.1 109 GSNECGQTGVGQNassmggfsECVfN--KDLQDSKNEilrGIVKIACGYQHCMIL 161
                 66666666666663333333211120..2233333334559***********975 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00034
                 TEEEEEE--GGGTTSSSS-....--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   2 GrVysWGrndyGqLGlgtt....esvlvPtkveglsgnrvvkvacGddhtval 50 
                 G   + G++ + qLG   +    e     ++v++ + +++v++ cG++ + ++
  EFC39364.1 165 GTMIGTGCSYQRQLGPIENdisyE---FTKLVSPETTTPIVDIQCGYFSSSCI 214
                 555667899999999866643332...22556666656*********998775 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 1.6
                 TTEEEEEE--GGGTT CS
        RCC1   1 dGrVysWGrndyGqL 15 
                 +G Vy  G+ +y +L
  EFC39364.1 217 NGMVYVVGQESYTRL 231
                 599*****9888776 PP

  == domain 5  score: -2.4 bits;  conditional E-value: 1.3
                 EEE--GG CS
        RCC1   6 sWGrndy 12 
                  WG+nd+
  EFC39364.1 270 NWGSNDD 276
                 4***997 PP

>> PHTB1_N  PTHB1 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.0   0.00015      0.92     137     179 ..       7      49 ..       1      58 [. 0.86
   2 ?    2.9   0.0    0.0092        55      64      85 ..     191     212 ..     178     225 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.00015
     PHTB1_N 137 vgpfggvkssrdficVqslDGkLsffeqdvvafsrlLpefllP 179
                 ++ + +v++++d +   ++DG+L f+ q+++a+  +L++  lP
  EFC39364.1   7 QIVIKEVSTGKDYMTLLTMDGRLLFMGQNTFALGSVLSGEKLP 49 
                 5667788899*************************99988887 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.0092
     PHTB1_N  64 llletqlkePILqvelgkfvss 85 
                  l++ ++ +PI+++++g+f+ss
  EFC39364.1 191 KLVSPETTTPIVDIQCGYFSSS 212
                 578899*************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (399 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 2287.94
//
Query:       EFC39365.1  [L=201]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.13   12.2   0.0       0.17   11.8   0.0    1.1  1  Y_phosphatase3  Tyrosine phosphatase family


Domain annotation for each model (and alignments):
>> Y_phosphatase3  Tyrosine phosphatase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   9.5e-06      0.17      55     133 ..      99     194 ..      94     195 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 9.5e-06
  Y_phosphatase3  55 DLRspeEreaeaplega.ryvhlpv.................eea.aeeekeeeeaeetlaelYrellesakkayrkvfealad.ee.pvlfHCt 128
                     DL +++E  + +p  ++ + vh  +                  ++ +++ ++e++  +++ +lY+ + +  +++++++ ++ ++ ++  + +HC 
      EFC39365.1  99 DLKDETEYFKANP--HIgELVHWTIignpingtdlpewlrkdLAIyEKKWDREDKLIDRVDQLYNWIHT--QDSIHNLNQDAQSaKAlVFYIHCE 189
                     7777777433355..222344433345555777777776653133366777777777888888887766..699999999999955588899*** PP

  Y_phosphatase3 129 aGKDR 133
                     aG DR
      EFC39365.1 190 AGMDR 194
                     ****9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (201 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      689  (0.0384294); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.33s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 1196.63
//
Query:       EFC39366.1  [L=395]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.004   16.7   0.0        1.7    8.1   0.0    2.3  2  VRP3      Salmonella virulence-associated 28kDa protein
  ------ inclusion threshold ------
        7.3    6.4  16.8        1.6    8.6  12.7    2.0  2  PYST-C1   Plasmodium yoelii subtelomeric region (PYST-C1)


Domain annotation for each model (and alignments):
>> VRP3  Salmonella virulence-associated 28kDa protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.0    0.0007       6.3     103     126 ..     112     135 ..     105     146 .. 0.90
   2 !    8.1   0.0   0.00019       1.7     171     215 ..     255     298 ..     234     315 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0007
                 EEEE-B-GGGHHHHHHHHHHHHT- CS
        VRP3 103 kfhisvqreqvpqafqalsgllfs 126
                 k h sv+r+ vp+af+++ + +f 
  EFC39366.1 112 KIHFSVKRKDVPKAFNVIGKYFFE 135
                 89***************9988875 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00019
                 HHHHHHHHHHHHHHHHHHTT--B----TT-B--TT-SSEEEEETT CS
        VRP3 171 llhktrqfiealesrlsesgivpGeyPesdvrPenwkyvsyrnel 215
                  l+  r++i  +e+ l +++i p  + + d+ P   ky+s+rne 
  EFC39366.1 255 PLRMFRKWIRHVEYLLEKENIEPNGCADGDL-PLGGKYASFRNET 298
                 57788*************************8.9999*******95 PP

>> PYST-C1  Plasmodium yoelii subtelomeric region (PYST-C1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6  12.7   0.00017       1.6      21      50 ..      38      68 ..      32      77 .. 0.80
   2 ?   -3.5   0.1         1     9e+03      20      33 ..     148     161 ..     144     167 .. 0.68

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00017
     PYST-C1 21 ekndIeskhetqLkNnNpkDdkddkddk.kr 50
                +   I  k+  + +NnN+ Dd dd dd+   
  EFC39366.1 38 KMHKITRKSNSKFNNNNNRDDHDDRDDNnSS 68
                5567999**************9999999433 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1
     PYST-C1  20 NekndIeskhetqL 33 
                 +e+  ++sk   +L
  EFC39366.1 148 DEETEVKSKNSGKL 161
                 56666777765555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (395 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       962  (0.0536561); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2338.29
//
Query:       EFC39367.1  [L=385]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0071   16.1   2.4       0.25   11.2   0.0    3.5  4  SAM_3     SAM domain (Sterile alpha motif)
  ------ inclusion threshold ------
      0.055   13.8   0.3      0.055   13.8   0.3    2.6  3  Ish1      Putative stress-responsive nuclear envelope protein


Domain annotation for each model (and alignments):
>> SAM_3  SAM domain (Sterile alpha motif)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.0   2.8e-05      0.25      11      50 ..      26      60 ..      19      64 .. 0.90
   2 ?    2.0   0.2     0.021   1.9e+02       2      15 ..     119     132 ..     118     134 .. 0.89
   3 ?   -1.0   0.0      0.17   1.6e+03       8      22 ..     174     188 ..     173     190 .. 0.88
   4 ?   -1.8   0.0      0.31   2.8e+03      21      33 ..     271     283 ..     269     286 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.8e-05
       SAM_3 11 tpeeVkaWLtakgFskktvesLgklsGaqLfsLskeeLeq 50
                t+e Vk+WL ++g++kk     ++++Ga+L   s+ +L +
  EFC39367.1 26 TTENVKQWLSEEGLDKK-----KNVTGAMLIDQSQSDLST 60
                689*************9.....999999999999998876 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.021
       SAM_3   2 dsiqitqkStpeeV 15 
                 ++i it++S+++eV
  EFC39367.1 119 TEIIITPSSSAQEV 132
                 5899*********9 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.17
       SAM_3   8 qkStpeeVkaWLtak 22 
                 +kSt +e++ +L+++
  EFC39367.1 174 KKSTFDEIHSFLQEH 188
                 589*********986 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 0.31
       SAM_3  21 akgFskktvesLg 33 
                  ++Fs+k +e+++
  EFC39367.1 271 TNEFSEKQTEMFA 283
                 799****999986 PP

>> Ish1  Putative stress-responsive nuclear envelope protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.3   6.1e-06     0.055       3      27 ..      24      47 ..      23      56 .. 0.81
   2 ?   -3.0   0.0       1.1   9.5e+03       7      16 ..     179     188 ..     176     189 .. 0.80
   3 ?   -1.4   0.1      0.33     3e+03       5      11 ..     221     227 ..     214     227 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 6.1e-06
        Ish1  3 tWSdsdLkkWLdshGipvskaastR 27
                 W++++ k+WL++ G+ + k+  t 
  EFC39367.1 24 RWTTENVKQWLSEEGLDK-KKNVTG 47
                7**************996.776665 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.1
        Ish1   7 sdLkkWLdsh 16 
                 ++++++L +h
  EFC39367.1 179 DEIHSFLQEH 188
                 7899999998 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.33
        Ish1   5 SdsdLkk 11 
                 SdsdLk+
  EFC39367.1 221 SDSDLKQ 227
                 8999995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       629  (0.0350828); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 2217.18
//
Query:       EFC39368.1  [L=360]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.036   13.9   0.2      0.097   12.5   0.2    1.7  1  DUF1508   Domain of unknown function (DUF1508)


Domain annotation for each model (and alignments):
>> DUF1508  Domain of unknown function (DUF1508)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.2   5.4e-06     0.097      12      42 ..      65      95 ..      64      97 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.4e-06
                -TTS-EEEEEEEBSSHHHHHHHHHHHHHHTT CS
     DUF1508 12 aaNgevIatsegYsskaaaenGIesVkknap 42
                ++N++ I +s  ++ k++a n I sV + +p
  EFC39368.1 65 HNNNNNIENSPSFTRKSSASNEISSVLSSSP 95
                89************************88776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       966  (0.0538792); expected 358.6 (0.02)
Passed bias filter:                      219  (0.0122148); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.54
# Mc/sec: 2022.71
//
Query:       EFC39369.1  [L=2853]
Description: dedicator of cytokinesis [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-76  256.9  38.5    1.1e-43  149.7  14.2    5.8  5  DHR-2     Dock homology region 2
    3.5e-22   79.2   2.8    1.8e-21   76.9   2.8    2.4  1  DOCK-C2   C2 domain in Dock180 and Zizimin proteins
  ------ inclusion threshold ------
       0.22   11.8   7.9         26    5.2   0.5    4.7  3  DUF5638   Family of unknown function (DUF5638)


Domain annotation for each model (and alignments):
>> DHR-2  Dock homology region 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.1     0.023   1.4e+02     190     230 ..    1000    1040 ..     973    1061 .. 0.85
   2 ?   -3.3   4.3      0.43   2.6e+03      52     210 ..    1432    1577 ..    1368    1594 .. 0.57
   3 !  149.7  14.2   1.8e-47   1.1e-43      42     373 ..    1914    2321 ..    1889    2344 .. 0.77
   4 !   66.7   0.1   2.5e-22   1.5e-18     347     435 ..    2448    2532 ..    2431    2570 .. 0.84
   5 !   52.8   0.1   4.2e-18   2.5e-14     434     524 ..    2601    2704 ..    2588    2707 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.023
       DHR-2  190 teeglvellekaiellkkgelyElaielyklliplyekkrd 230 
                   +  l++ ++ + + ++    +E ++++yk+li +ye +++
  EFC39369.1 1000 INLFLLKFFRLVNNTVSVTPTFEEIADVYKTLIQTYEYEKQ 1040
                  555678888899999999999****************9987 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 0.43
       DHR-2   52 dkelkessfpeqvkellkrlrtvlkatvkmkeekedpemladlqyslansyksspdlritwLeslaekhaenenfsEaaqclihaaaLiaeylkllk 148 
                  ++e +++++++ ++el +++++v ++ +  ++  ++ +   + +++  +   +  d+++t L++l    +e++ + E  ++++    L++  ++ + 
  EFC39369.1 1432 NAESNQKKITTAIEELRRKISQVERDILAAQDSLNQAKQNKTKKSTEPEKKLNHLDVQLTTLKQLLLT-KEKQLLEEFETTKTEKRMLLSVFVQIT- 1526
                  44556667777788888888777777777765555554444444443333335566777777776543.334455555555555555555333333. PP

       DHR-2  149 kipkklgasaFekispnvlkeesesasalkedsgvcdseefteeglvellekaiellkkgel 210 
                  +  ++ ++ ++ ki p          s++  d    d  +f+ + l+ +++++++ ++ g++
  EFC39369.1 1527 TNCDENSLRSLWKIKPASE--D----SNMYHD----DGLHFSSK-LLMIFQMCVQSFEYGGY 1577
                  4444455555556655432..2....233332....34455544.44566666666666653 PP

  == domain 3  score: 149.7 bits;  conditional E-value: 1.8e-47
       DHR-2   42 lktinsyaksdkelkes.........sfpeqvkellkrlrtvlkatvkmk....eekedpemla........dlqyslansyksspdlritwLesla 117 
                  +k+i++ a+++k              +f++ + +l+k+l +++++t++++    + k+ + +++        +l y+++  y++ p+lr+ wLe+la
  EFC39369.1 1914 FKKIENKADQKK----FgqkvlevldQFHDLLSDLSKKLLSLVQDTMSIRatmiKRKQSETSTVtydpfkteELLYRISDNYSKLPELRLAWLEQLA 2006
                  333444333222....12223555556666666666666666666666655444222222223335666666999********************** PP

       DHR-2  118 ekhaenenfsEaaqclihaaaLiaeylkll.............kkipkklgasaFekispnvlkeesesasalkeds....gvcdseefteeglvel 197 
                  + h+   ++ E a+c++ + +L+ +yl +               ++ + l +s+F +isp+++ e + +++ ++++s    g  + ++ + +++v++
  EFC39369.1 2007 SYHKGLAQYEESAHCYLRILSLVFDYLDHQatkkftpnsikteTSVLEILPLSQFYSISPMLI-EFKVNQTGIQTQSllggGNSKYDYMSDQSIVNY 2102
                  ***************************999999999987777656666666**********99.999999999999899977777788899****** PP

       DHR-2  198 lekaiellkkgelyElaielyklliplyekk.rdykklseihkklaelyekivetsks.ekRl.................................. 258 
                  + k+i+ l+ +e++E +i lykllip++e+k  ++++l  i+ +l++ly+k  + +++ ++++                                  
  EFC39369.1 2103 ILKTIDSLELAECFEHCIMLYKLLIPIFESKyANFTQLHIIYDRLTQLYKKCSSFQSTsNSKVptspsdnettnalslsnisslsaskttenetdsr 2199
                  *******************************889******************998777744445555555555666666666666666666666666 PP

       DHR-2  259 .fgtYyRVgFyGkkFeeldgkeyvYkepkltrLseiserlksqysekfg...eekveiikdskpvdkseldpdkaYiqitaVePyfeeeelk....e 347 
                    + YyRV+F G++F+eldgk y+Yk pkl +L+++++++++ y + ++   +++  +++ +++++ +  +++k  iqi +V+P++ + +++    +
  EFC39369.1 2200 vYSFYYRVKFVGRAFGELDGKVYIYKMPKLFKLFKMKNKMLEIYGKDVEvvsKDEAGVVTADDELS-TGSESNKKVIQINHVKPFLPTVDQMkilrK 2295
                  5**********************************************9988555888888888873.445889999**********99999445546 PP

       DHR-2  348 rktsFernnnvnrFvfetPFtksgkk 373 
                  +  +++r  n++  v + P t+++++
  EFC39369.1 2296 KFDDLNRLSNISTSVNSAPSTRGSDR 2321
                  66666677787777777777777754 PP

  == domain 4  score: 66.7 bits;  conditional E-value: 2.5e-22
       DHR-2  347 erktsFernnnvnrFvfetPFtksgkkaqgsleeqwkrrtiLttensfPylkkRlevvskeeielsPievaieeiekkteeleaaikae 435 
                   r ++F+rn n+n F++e     +g     ++++ +k+++ +tte++fP++ +Rlev +++e+ lsPie++ie+i++++++le a+++ 
  EFC39369.1 2448 TRDSEFQRNMNLNHFFYEYSVAAKG----ADITQTYKKKILITTEEYFPNVMTRLEVAEEKEFTLSPIENSIEMIDTQVKKLETAMNSV 2532
                  7999*****************9999....37******************************************************9984 PP

  == domain 5  score: 52.8 bits;  conditional E-value: 4.2e-18
       DHR-2  434 aeppnlktLqmlLqGsvavqVNaGpleiaeaFLsee.....kakelpaekvekLkeafreflkvckeaLelnkkliked........qrelqeeLee 517 
                   +p  ++tLqm+LqGsv + V +Gp ++ e+FL+ e     k+++ +++ ++kL e + +fl  c+++++l++ +i+++        +r l+ eLe+
  EFC39369.1 2601 INPHTVSTLQMILQGSVQARVGEGPKKVVEIFLNREfrerwKVQQGNSDLITKLNERCFRFLLLCDRGVKLHSLIIHSQtptatnnkDRILHAELEK 2697
                  467899******************************9999999999*******************************5555566666999******* PP

       DHR-2  518 gfeklke 524 
                  gf++ k+
  EFC39369.1 2698 GFHEVKS 2704
                  ***9875 PP

>> DOCK-C2  C2 domain in Dock180 and Zizimin proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   76.9   2.8   2.9e-25   1.8e-21       2     189 ..     775     984 ..     774     987 .. 0.71

  Alignments for each domain:
  == domain 1  score: 76.9 bits;  conditional E-value: 2.9e-25
     DOCK-C2   2 gdvrNdlYvtlksgefsskgskssakniqvtvevrds........dgerlekaiyl..g...sgeelvsefrsvvlyhnkqptfneeiKialpielt.. 85 
                 +++rN+lY++++s++fs k+   ++kniq+tv + d+         ++r ++++y+  +   s++        +v+ +n++p+f++eiK  +p+     
  EFC39369.1 775 TNLRNELYIYPQSANFS-KF-AVKNKNIQITVSYNDTdqnfslnnMEQRNKGLFYKpfTsnnSSDRINEGECVSVALKNEKPEFSDEIKCIIPCRYPte 871
                 679*************6.56.5689************777766542222446666533133365666667777999****************9876555 PP

     DOCK-C2  86 ...ekhHLlFtfrhvsceekkk....ekdkeeeekpfgyaflpLlk......edgraflkd...gehelpvykk.elppsgYlslpssrtssseeqkgp 167
                     ++HL+F f++vs +e  +    + + +++++++g++fl+ +k      ++ +++lkd   g++elpvy   + p+++Yl l  +  ++++     
  EFC39369.1 872 dedCRQHLVFKFYNVSHKETIQkkasDVELSQSRTLIGVSFLKVYKkvtttiDKRKIILKDlinGDFELPVYPVlNIPNANYLRLCDQ-IMDPSLV--- 966
                 55569***********976544778844445679************444444444444444555********74457888***87533.2222222... PP

     DOCK-C2 168 sekwldnskdtfkvrtklcSTi 189
                 ++k    + +tfkv++   S i
  EFC39369.1 967 HIK----PSATFKVKIIPYSFI 984
                 344....788888888777755 PP

>> DUF5638  Family of unknown function (DUF5638)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1     0.017     1e+02      17      68 ..    1064    1113 ..    1055    1127 .. 0.84
   2 ?    5.2   0.5    0.0043        26      47      92 ..    1431    1476 ..    1406    1482 .. 0.87
   3 ?    3.9   0.1     0.011        65      39      90 ..    1913    1964 ..    1897    1976 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.017
                  HHHT------HHHHHHHHHHHHHHHHHHHT--SHHHHHHHHHHHHHHHHHHH CS
     DUF5638   17 salfedkelsekikkqlqeiktyYnesftkakkektkeeiveeYeelvllls 68  
                  + + +   ++++   +l +i  ++ e+++  +++ + + +++ Y++++   s
  EFC39369.1 1064 DWIIDTFGKDKNYTTELWKIILFFIEKYN--QHSASSSTVLKIYQKYHFRFS 1113
                  446667778899999*************9..888999999****99987665 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0043
                  --SHHHHHHHHHHHHHHHHHHHHHHTTSS-HHHHHHHHTTT---HH CS
     DUF5638   47 akkektkeeiveeYeelvlllsqvkngeisadeAleaiekktesrk 92  
                   + e+++++i++  eel  ++sqv+   + a++ l++ +++ ++++
  EFC39369.1 1431 RNAESNQKKITTAIEELRRKISQVERDILAAQDSLNQAKQNKTKKS 1476
                  4678899**********************99999999998887765 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.011
                  HHHHHHHT--SHHHHHHHHHHHHHHHHHHHHHHTTSS-HHHHHHHHTTT--- CS
     DUF5638   39 yYnesftkakkektkeeiveeYeelvlllsqvkngeisadeAleaiekktes 90  
                  ++++  +ka ++k +++++e  +++++lls+++++ +s+ +   +i +++ +
  EFC39369.1 1913 FFKKIENKADQKKFGQKVLEVLDQFHDLLSDLSKKLLSLVQDTMSIRATMIK 1964
                  77777799*****************************987766666555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2853 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1454  (0.0810977); expected 358.6 (0.02)
Passed bias filter:                      411  (0.0229238); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.41u 0.32s 00:00:01.73 Elapsed: 00:00:00.53
# Mc/sec: 16095.72
//
Query:       EFC39370.1  [L=491]
Description: mitogen-activated protein kinase ERK1 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-69  233.1   0.0    5.9e-69  232.4   0.0    1.4  1  Pkinase        Protein kinase domain
    1.4e-27   96.6   2.2    3.1e-27   95.5   0.1    2.3  2  Pkinase_Tyr    Protein tyrosine kinase
    0.00014   21.0   0.2    0.00014   21.0   0.2    1.5  2  Haspin_kinase  Haspin like kinase domain
    0.00038   19.9   0.1    0.00065   19.1   0.1    1.4  1  Kdo            Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
       0.42   10.9   5.8         57    4.0   0.0    2.6  2  DUF4611        Domain of unknown function (DUF4611)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  232.4   0.0   1.6e-72   5.9e-69       1     264 []      20     328 ..      20     328 .. 0.93

  Alignments for each domain:
  == domain 1  score: 232.4 bits;  conditional E-value: 1.6e-72
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE......SSEEEEEEE--TTEBHHHHHHHHS CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee......kdelylvleyveggeladllerkg 93 
                 y++l+ +G+Gs+G V  a+++ t+ +vA+Kk+ +  + +    ++lrE+kil  l+hpn++ l++v          +ely+ +++++++ l+++++ ++
  EFC39370.1  20 YQDLNVIGKGSYGIVCAAKDTLTNSKVAIKKVIRCFDHHVFAVRLLREVKILGFLNHPNVIDLKHVQLPfpdrdnFTELYMYTDLMDTD-LKTIIQSSQ 117
                 788999************************************************************988888888999*********66.*******9* PP

                 S--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS...................BCTTTSCGGGS-HHHH.TTS CS
     Pkinase  94 slseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...................ltsfvgtseYlAPEvl.ken 172
                  l++++++++++qil++++y+Hs ++iHrDlKp+NiLi+++ ++Ki+D+Gla+ ++ +++                   lt++v+t++Y+APE+l ++n
  EFC39370.1 118 ELTNDHIQFFMYQILKAVHYIHSGNVIHRDLKPSNILINSDCNIKICDLGLARGYNDGTNanesvlkgllkgqkqmkpkLTEYVVTRWYRAPELLlQSN 216
                 **********************************************************999**********************************9*** PP

                 CBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT........SHH...HHHTTS............................-H CS
     Pkinase 173 eyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg........etkeklpeasei............................se 235
                  y+k+vDvWs+G+i++ell ++p+f+   g++    ++dql+ki++++g        e          i                             +
  EFC39370.1 217 AYGKQVDVWSVGCIFAELLGREPLFR---GSS----HYDQLVKIFDVIGtpkdktdfE------G---IeltdssynilqqikvkpkrdftsifpnaTN 299
                 **************************...554....8899999999999653322221......1...12346677778888***************** PP

                 HHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 236 eakdllkkllkkdpkkRltaeellqhpyl 264
                 +a dll+kll+  pk+R++a+e+l+hpy+
  EFC39370.1 300 DAVDLLEKLLCFSPKQRISASEALEHPYF 328
                 ****************************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   95.5   0.1   8.8e-31   3.1e-27       5     203 ..      24     237 ..      21     281 .. 0.80
   2 ?   -2.7   0.3      0.77   2.8e+03     194     230 ..     381     417 ..     379     422 .. 0.78

  Alignments for each domain:
  == domain 1  score: 95.5 bits;  conditional E-value: 8.8e-31
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH.HHHHHHHHHHHHTS-BTTB--EEEEEE......SSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateee.keelleeakimkklkhpnivkllgvct......keepllivteyvkgGdLlkfLrkk 95 
                  + +G+G++G V+ ++ +     ++ kVa+K++ +  +++    +ll+e+ki+  l+hpn++ l  v +      +  +l++ t++++  dL++ ++++
   EFC39370.1  24 NVIGKGSYGIVCAAKDT----LTNSKVAIKKVIRCFDHHVfAVRLLREVKILGFLNHPNVIDLKHVQLpfpdrdNFTELYMYTDLMDT-DLKTIIQSS 116
                  679*********99988....8999****99966665555499***********************9988743333449999999975.999999997 PP

                  CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEE...............EETTSSTSGGGGS.-HHHH CS
  Pkinase_Tyr  96 ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddey...............vkkeeaklpvkWm.apEsl 177
                    ++lt +++  f++q+ k+++y++s +++Hrdl   N+L++++  +ki+D GLar  ++  +                + k ++ +  +W+ apE l
   EFC39370.1 117 --QELTNDHIQFFMYQILKAVHYIHSGNVIHRDLKPSNILINSDCNIKICDLGLARGYNDGTNAnesvlkgllkgqkqmKPKLTEYVVTRWYrAPELL 212
                  ..9*****************************************************9854433333445554433211122223346678888***87 PP

                  HHSE.EEHHHHHHHHHHHHHHHHTTSS CS
  Pkinase_Tyr 178 kekk.ftsksDvWsfGvllwEiftlge 203
                   +++ + ++ DvWs G +  E++   +
   EFC39370.1 213 LQSNaYGKQVDVWSVGCIFAELLG--R 237
                  55444****************963..4 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 0.77
                  HHHHHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTS CS
  Pkinase_Tyr 194 llwEiftlgespypglkneevleklkegkrlekpekc 230
                  + +E+ t  + p+++  +++ +++ +++++ +  ++ 
   EFC39370.1 381 TRYELQTSMKPPVSTAVQQNNVQQTTNNYQPQSQHYN 417
                  5689999999999999888889999888887766654 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.2   3.8e-08   0.00014     176     257 ..      90     172 ..      29     184 .. 0.67
   2 ?   -4.0   0.2       1.5   5.4e+03      44      63 ..     389     408 ..     372     426 .. 0.54

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 3.8e-08
  Haspin_kinase 176 pdfyseqqlflvlllkdkGtdLeev.klkswkqalsi...fwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRle 257
                    pd  + ++  l+++ + + tdL+++ + ++  +  +i   ++qi+k ++   +  +  HRdL+  niL+++  n+ ++dl l+R  
     EFC39370.1  90 PDRDNFTE--LYMYTDLMDTDLKTIiQSSQELTNDHIqffMYQILKAVHYIHS-GNVIHRDLKPSNILINSDCNIKICDLGLARGY 172
                    44444444..4445555667888875333333333441004555555555543.4677**************************76 PP

  == domain 2  score: -4.0 bits;  conditional E-value: 1.5
  Haspin_kinase  44 islPvkdqvsrdkikkklrn 63 
                    ++ Pv+++v ++++++  +n
     EFC39370.1 389 MKPPVSTAVQQNNVQQTTNN 408
                    34444444444444443333 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.1   1.8e-07   0.00065     103     188 ..     107     188 ..      44     204 .. 0.78

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 1.8e-07
         Kdo 103 qdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDldkarlrlradrwrekdLarLkr 188
                  dL++++++ +el +   +  + ++ ++++ +h+ +v H+dl + nil++ +   +++i+ + l +++    ++ ++e  L+ L++
  EFC39370.1 107 TDLKTIIQSSQELTNDHIQFFMYQILKAVHYIHSGNVIHRDLKPSNILINSDC--NIKICDLGLARGY--NDGTNANESVLKGLLK 188
                 59******99999999999999****************************998..5555544444444..4456666666666665 PP

>> DUF4611  Domain of unknown function (DUF4611)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.0     0.016        57      22      45 ..     177     200 ..     173     208 .. 0.85
   2 ?    3.8   5.8     0.018        65      42      76 ..     405     439 ..     384     455 .. 0.50

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.016
     DUF4611  22 pgeadrlksllsgvaqlreevsel 45 
                 + + + lk+ll g +q++ + +e 
  EFC39370.1 177 NANESVLKGLLKGQKQMKPKLTEY 200
                 455689************999986 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.018
     DUF4611  42 vsellstlveqeaqddvaaagdeeeegededdeee 76 
                 +++ ++++ ++  +++++ ++d+e+++ d+++ e+
  EFC39370.1 405 TTNNYQPQSQHYNHQQQQYDEDDESDEGDDEEVED 439
                 34444444444433333333444433333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1699  (0.0947627); expected 358.6 (0.02)
Passed bias filter:                      554  (0.0308997); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.77u 0.39s 00:00:01.16 Elapsed: 00:00:00.56
# Mc/sec: 2640.72
//
Query:       EFC39371.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-09   37.6   7.7    4.1e-09   36.7   7.7    1.5  1  RGS            Regulator of G protein signaling domain
     0.0022   17.3   0.1     0.0043   16.4   0.1    1.4  1  DUF4420        Putative  PD-(D/E)XK family member, (DUF4420)
      0.005   15.7   0.1     0.0059   15.5   0.1    1.2  1  C12orf66_like  KICSTOR complex C12orf66 like
  ------ inclusion threshold ------
      0.033   13.5   0.0      0.059   12.7   0.0    1.3  1  NicO           High-affinity nickel-transport protein
        5.5    7.6   6.4    6.7e+02    0.9   6.4    2.9  1  COX16          Cytochrome c oxidase assembly protein COX16


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.7   7.7   1.2e-12   4.1e-09       2      84 ..      74     175 ..      73     202 .. 0.80

  Alignments for each domain:
  == domain 1  score: 36.7 bits;  conditional E-value: 1.2e-12
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS................. CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke................. 83 
                 le++l+++++ +lFre+ e+efs en++F+  + ++k +  +    k+ +eI ++++++ s+ e+n++++++ e  k  e++                 
  EFC39371.1  74 LENILKNEDLFNLFREYSEKEFSLENIEFYSVMLKLKVQ--KVVSEKELDEIDDTFIKNYSKYEVNLPSSCKREFYKLKEQAqekthqveysalwqvfg 170
                 89*************************************..5555667**************************9999888855555555555555444 PP

                 ....S CS
         RGS  84 ....q 84 
                      
  EFC39371.1 171 ndlvL 175
                 44444 PP

>> DUF4420  Putative  PD-(D/E)XK family member, (DUF4420)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.1   1.2e-06    0.0043     211     280 ..      38     106 ..      34     109 .. 0.95

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 1.2e-06
     DUF4420 211 yLvvlrleesrtGeslkelvneirelleadpaaldkfeekLakagyldeheekykerrykvrkarfyeVd 280
                 +L+ ++l  +++G  l e+ ++ir+  +++ +  d++e+ L +   ++  +e y+e+++++++ +fy+V 
  EFC39371.1  38 ILCFVFLTMNGGGVVLIEIYKRIRYAKSQKTNSADDLENILKNEDLFNLFRE-YSEKEFSLENIEFYSVM 106
                 79*************************************************5.99*************96 PP

>> C12orf66_like  KICSTOR complex C12orf66 like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   1.7e-06    0.0059     127     169 ..      91     133 ..      45     167 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.7e-06
                    THHHHHHHHHHHHHHHHHGGGSSS--HHHHHHHHSTTTGGG-- CS
  C12orf66_like 127 sfvqarlelldfyeklaslgsskvvnseelvvaldallkkysk 169
                    s ++  le ++fy ++  l+++kvv  +el+   d+ +k+ysk
     EFC39371.1  91 SEKEFSLENIEFYSVMLKLKVQKVVSEKELDEIDDTFIKNYSK 133
                    335667999********************************97 PP

>> NicO  High-affinity nickel-transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.6e-05     0.059      52     128 ..       8      84 ..       4     114 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.6e-05
        NicO  52 vlvavllvvaavlvlrltslsetgaaigteiasFllvilllnllllrklrklfrklerlgrapaaeleaalakrgll 128
                 +++++l++v+ + +   ++ +++ + i+  i  F+++++ +  ++l++++k +r +++++  +a +le++l+++ l 
  EFC39371.1   8 IVICILVAVGTASLDVQQKEYQNVGGIFNTILCFVFLTMNGGGVVLIEIYKRIRYAKSQKTNSADDLENILKNEDLF 84 
                 677888888888888888888888899999**************************99999999*******997544 PP

>> COX16  Cytochrome c oxidase assembly protein COX16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   6.4      0.19   6.7e+02      55      62 ..     144     151 ..      40     198 .. 0.58

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.19
       COX16  55 eeyerlqa 62 
                  e+++l++
  EFC39371.1 144 REFYKLKE 151
                 33333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1533  (0.0855039); expected 358.6 (0.02)
Passed bias filter:                      639  (0.0356406); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.36s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 1118.50
//
Query:       EFC39372.1  [L=441]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-18   66.1   5.5    0.00042   20.0   0.1    5.2  5  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    4.4e-07   30.4   3.2      0.011   16.3   0.0    5.0  5  RCC1      Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   2.1e-06     0.019       1      24 [.      75      98 ..      75      99 .. 0.97
   2 !   13.1   0.0   7.1e-06     0.063       4      30 .]     139     166 ..     132     166 .. 0.91
   3 !   20.0   0.1   4.6e-08   0.00042       3      26 ..     197     220 ..     196     226 .. 0.88
   4 !   15.3   0.1   1.5e-06     0.013       1      24 [.     248     271 ..     248     277 .. 0.95
   5 ?    0.9   0.0     0.047   4.2e+02      11      21 ..     305     315 ..     303     316 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 2.1e-06
      RCC1_2  1 VksvsaGdyHscaLtedGeVlcWG 24
                +ksvs+G +++  L +dG+++ +G
  EFC39372.1 75 IKSVSSGKSFAALLANDGRLFVCG 98
                89*********************9 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 7.1e-06
      RCC1_2   4 vsaGdyHscaLtedGe.VlcWGsNsdGQ 30 
                 +++G y+ +a+++d   +++ G+N++GQ
  EFC39372.1 139 IACGMYFMMAMSDDRSnIFSAGQNECGQ 166
                 99**********99777**********9 PP

  == domain 3  score: 20.0 bits;  conditional E-value: 4.6e-08
      RCC1_2   3 svsaGdyHscaLtedGeVlcWGsN 26 
                 ++s+G+ H++a + dG+++++G+ 
  EFC39372.1 197 KISCGYQHAIAYSKDGNLYGTGCS 220
                 7*********************75 PP

  == domain 4  score: 15.3 bits;  conditional E-value: 1.5e-06
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWG 24 
                 +++v aG ++s+ L+++G V+ +G
  EFC39372.1 248 IIDVQAGFFFSVCLDSEGMVYVTG 271
                 79*********************9 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.047
      RCC1_2  11 scaLtedGeVl 21 
                 +++Lt dG V+
  EFC39372.1 305 AFFLTQDGQVY 315
                 799*******8 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.48   4.3e+03      35      49 ..      72      87 ..      56      88 .. 0.78
   2 ?   -0.8   0.0      0.29   2.6e+03       1       9 [.      91      99 ..      91     100 .. 0.91
   3 !    4.0   0.0    0.0088        79      30      50 .]     126     149 ..     115     149 .. 0.77
   4 !    6.0   0.2    0.0021        19      36      49 ..     194     207 ..     155     208 .. 0.63
   5 !   16.3   0.0   1.2e-06     0.011       1      50 []     211     261 ..     211     261 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.48
                S.-EEEEEEETTEEEE CS
        RCC1 35 n.rvvkvacGddhtva 49
                +  +++v++G ++ ++
  EFC39372.1 72 KmTIKSVSSGKSFAAL 87
                457899****999876 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.29
                TTEEEEEE- CS
        RCC1  1 dGrVysWGr 9 
                dGr++ +G+
  EFC39372.1 91 DGRLFVCGK 99
                9******95 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.0088
                 GGGTTS.....-EEEEEEETTEEEEE CS
        RCC1  30 eglsgn.....rvvkvacGddhtval 50 
                 e++  n     +++ +acG ++ +a+
  EFC39372.1 126 ELS--NkqvvdKFSNIACGMYFMMAM 149
                 344..344889**********99986 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.0021
                 -EEEEEEETTEEEE CS
        RCC1  36 rvvkvacGddhtva 49 
                    k++cG++h +a
  EFC39372.1 194 GLEKISCGYQHAIA 207
                 6789*******987 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 1.2e-06
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS.-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgn.rvvkvacGddhtval 50 
                 dG++y+ G++ ++qLG+ ++  +   +k++ ++ +  +++v +G +++v+l
  EFC39372.1 211 DGNLYGTGCSFQNQLGTIDSGICYEFRKISRPKTDnQIIDVQAGFFFSVCL 261
                 9****************9994444557898888778************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       440  (0.0245412); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 2500.40
//
Query:       EFC39373.1  [L=187]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.11   10.3   0.0       0.13   10.0   0.0    1.0  1  CCDC158   Coiled-coil domain-containing protein 158


Domain annotation for each model (and alignments):
>> CCDC158  Coiled-coil domain-containing protein 158
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   7.5e-06      0.13     858     983 ..      21     148 ..      16     168 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 7.5e-06
     CCDC158 858 slkprllkpasvtrshsnvpssqstasflshhsikaealkedptrdlkqllqelrsvineepavklskaeekgratslgaledrvrdaiiesslrsdic 956
                 +  prl+  a +  + s  ps  s +    hh + +e    +   d++  +  +r v   + a    +   +  + +lg l + + d+  +++  s+i 
  EFC39373.1  21 ANDPRLIAIAFYKPPSSSKPSLSSDSNSNHHHQTVSEYYIYLNPTDKRGYRCIVRLVNSSDMASTFNREYTRSERVGLGILLQFMSDCYSKVMPISQIS 119
                 5679***9999999999****999999999999999998888778999999999999999999999999999999************************ PP

     CCDC158 957 hssstvleteklkssellsr..epvalha 983
                  + +++ + + + ++++l r  ep  lh 
  EFC39373.1 120 IAGNNSHQFNESLGETILGReeEPSFLHG 148
                 ********999999999988335888885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (187 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       349  (0.0194657); expected 358.6 (0.02)
Passed bias filter:                      298  (0.0166211); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1074.80
//
Query:       EFC39374.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.091   12.8   0.3      0.091   12.8   0.3    1.9  2  DUF3551   Protein of unknown function (DUF3551)


Domain annotation for each model (and alignments):
>> DUF3551  Protein of unknown function (DUF3551)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1      0.31   5.6e+03      16      23 ..      18      23 ..       6      37 .. 0.42
   2 ?   12.8   0.3   5.1e-06     0.091      39      69 ..      74     104 ..      65     111 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.31
     DUF3551 16 aaattpAe 23
                +++  +A+
  EFC39374.1 18 SLS--HAA 23
                222..222 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 5.1e-06
     DUF3551  39 pgeCsyatyeqCraaASGrladCivNpraaf 69 
                 +++ ++  ++ C+ +A   +a+C++N ++a+
  EFC39374.1  74 LNNGNFFLLKNCKSTANNGNAYCGTNNFLAY 104
                 567789999*******************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 1414.75
//
Query:       EFC39375.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       718  (0.0400469); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.47u 0.25s 00:00:00.72 Elapsed: 00:00:00.44
# Mc/sec: 1111.63
//
Query:       EFC39376.1  [L=652]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.4e-42  144.9  12.2    3.4e-42  144.9  12.2    2.1  2  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t
    4.9e-26   90.2   8.5    1.4e-25   88.8   8.5    1.8  1  PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
    2.3e-08   33.8   0.0      7e-08   32.2   0.0    1.8  1  E1-E2_ATPase     E1-E2 ATPase
  ------ inclusion threshold ------
      0.017   15.0   1.9      0.017   15.0   1.9    2.0  2  DUF4360          Domain of unknown function (DUF4360)
       0.15   12.3   0.0       0.39   10.9   0.0    1.7  1  ChapFlgA_N       FlgA N-terminal domain


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.6      0.31   1.1e+03     190     200 ..     152     162 ..     113     196 .. 0.48
   2 !  144.9  12.2   9.6e-46   3.4e-42      80     245 ..     335     509 ..     333     513 .. 0.94

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.31
  PhoLip_ATPase_C 190 lyflflllyss 200
                      +yflf++++++
       EFC39376.1 152 CYFLFMAVLQT 162
                      22222222222 PP

  == domain 2  score: 144.9 bits;  conditional E-value: 9.6e-46
  PhoLip_ATPase_C  80 ivlgifdqdvsaelllkyPelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvalet 173
                      ++++++d+dvsa++++k+PelY++gqkn++fn k+f+ w++++l++sl++ff++y++l ds+f dg++ d +++g+++++++++v+ lk+++et
       EFC39376.1 335 FMIAVMDRDVSADVAEKFPELYYQGQKNRFFNAKVFISWVVNSLFHSLVCFFVPYYCLVDSKFLDGHDIDPETIGIVIYSCVLVVISLKLCIET 428
                      6899*********************************************************999****************************** PP

  PhoLip_ATPase_C 174 ktwtliliililgsillyflflllyssllps.........ssefygvleelfsspsfwlvlllvvvvallpdllikvlkrt 245
                      ++wt+++++++ gs+l++ +f+++y s++           ++++++   ++f +p+f++++llv+++++++d+++k + r+
       EFC39376.1 429 SSWTWVNVLIYTGSLLSWPAFIFVYGSIYYIfgypypvisEFYGITERWRIFLTPQFYMIVLLVTFMCCIRDIFWKGFVRM 509
                      ***************************99999******555555555789**************************99876 PP

>> PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.8   8.5   3.8e-29   1.4e-25       2      66 ..     110     174 ..     109     175 .. 0.96

  Alignments for each domain:
  == domain 1  score: 88.8 bits;  conditional E-value: 3.8e-29
  PhoLip_ATPase_N   2 yindreenekkkyasNkIsTsKYtlltFlpknLfeqFrrvaNlYFLviailqliPqisplspvtt 66 
                      ++nd+ +n+++k+ +N+I+T+KYt+++Fl+knL+eqF+r+aN+YFL++a+lq+iP++sp++++t+
       EFC39376.1 110 FANDEMSNATNKFIDNSITTTKYTFYNFLFKNLYEQFHRFANCYFLFMAVLQTIPTLSPTGQFTA 174
                      57999999999****************************************************97 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.2   0.0     2e-11     7e-08       4      78 ..     205     311 ..     203     321 .. 0.82

  Alignments for each domain:
  == domain 1  score: 32.2 bits;  conditional E-value: 2e-11
                   --EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.....EEE-TTTS---S-EE-...........................G-TT CS
  E1-E2_ATPase   4 pptakvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa.....evdesaLTGEslpvek...........................ekgd 68 
                    + a+v+r+++ e+i  k++++GDiv++ +++  p+D ++v++s+      v++s+L GE     k                           +++ 
    EFC39376.1 205 NRIAHVLRGDKFEDIFWKDVKTGDIVKVDNKEPFPCDLILVSSSEsqglcYVETSSLDGETNLKIKrcrhetlelstpealdktrmivecekpNNRL 301
                   56899*************************************776666779**********999998888877777777777777777777444444 PP

                   EE-TT-EEEE CS
  E1-E2_ATPase  69 mvfsGtvvvs 78 
                   + f Gt+v+s
    EFC39376.1 302 YKFEGTMVLS 311
                   4456666665 PP

>> DUF4360  Domain of unknown function (DUF4360)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   1.0      0.67   2.4e+03     113     147 ..      63     103 ..      26     134 .. 0.57
   2 ?   15.0   1.9   4.6e-06     0.017      69     149 ..     568     649 ..     531     652 .] 0.73

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.67
     DUF4360 113 lsgdytltdevdvasavwspC......gesailnintelrl 147
                 ++++y+ t++ ++++   s        g+  ++ni+ +  +
  EFC39376.1  63 INTNYNSTNNPSTQHRSISDMftgnevGAFNTFNIQQQHDA 103
                 23344444444444444444444333344455555555555 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 4.6e-06
     DUF4360  69 favvsadyrGyasldagvtatfqatyyfsgdaeqastqttlsGplsg..dytltdevdvasavwspCgesailnintelrlts 149
                  +v++ +yrG+a  +++++++f  +yy   ++++++ + + ++ +++  + t+t+++ +++  +s  +++ i+ni ++  +ts
  EFC39376.1 568 TSVAKFNYRGFAFSQTEQQGDFLKQYYNGTSSTNNNNNGNNTNTTNNttTTTTTSNTGMNTLPNS-ANDNVIINISNDDIITS 649
                 689999*********************98777665555555555553113444444444443333.35668999998887755 PP

>> ChapFlgA_N  FlgA N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00011      0.39      25      69 ..     261     301 ..     255     304 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00011
  ChapFlgA_N  25 gnldprlrlpacd.eaLevelpsgsrplGrtsvkvrcngpeppwtv 69 
                  + + +l++++c+ e+Le++ p++ ++   t++ v+c++p++  ++
  EFC39376.1 261 LDGETNLKIKRCRhETLELSTPEALDK---TRMIVECEKPNN--RL 301
                 5667899******99999998888655...**********95..44 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (652 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1522  (0.0848904); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.71u 0.29s 00:00:01.00 Elapsed: 00:00:00.48
# Mc/sec: 4121.72
//
Query:       EFC39377.1  [L=1182]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.9e-85  286.6  22.2    1.9e-85  286.6  22.2    2.7  3  PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-t
    8.9e-24   83.0   9.1    8.9e-24   83.0   9.1    2.4  3  PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
    2.5e-11   43.4   0.0    6.2e-11   42.1   0.0    1.6  1  E1-E2_ATPase     E1-E2 ATPase
    3.7e-11   43.0   0.2    3.5e-10   39.8   0.0    2.6  2  Cation_ATPase    Cation transport ATPase (P-type)
    6.1e-10   39.7   0.0    1.8e-06   28.4   0.0    3.1  3  Hydrolase        haloacid dehalogenase-like hydrolase
  ------ inclusion threshold ------
      0.015   15.1   1.7      0.027   14.3   1.7    1.4  1  DUF4360          Domain of unknown function (DUF4360)


Domain annotation for each model (and alignments):
>> PhoLip_ATPase_C  Phospholipid-translocating P-type ATPase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   1.1       1.5   4.6e+03     190     201 ..      38      49 ..      10      78 .. 0.42
   2 ?   -2.1   2.8      0.85   2.5e+03     150     186 ..     256     288 ..     214     341 .. 0.45
   3 !  286.6  22.2   6.2e-89   1.9e-85       1     245 [.     785    1038 ..     785    1042 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.5
  PhoLip_ATPase_C 190 lyflflllyssl 201
                      +yflf+++++++
       EFC39377.1  38 CYFLFMAVLQTI 49 
                      233333333332 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.85
  PhoLip_ATPase_C 150 lqlfgtlvftalvlvvnlkvaletktwtliliililg 186
                      l l+ ++v ++lvl + + +++    wt ++  ++++
       EFC39377.1 256 LILLVLVVQIILVLSCDIALMV----WTNFNAGAWYL 288
                      3333333333333333333333....22222222222 PP

  == domain 3  score: 286.6 bits;  conditional E-value: 6.2e-89
  PhoLip_ATPase_C    1 vraSDyaiaqFrfLkrLLlvhGrwsyrRisklilyffyKnvvftlvqfwfqfyngfsgqslyeswlltlynllftslpvivlgifdqdvsae 92  
                       v+aSDyai+qFrfLkrLLlvhGrwsyrR+skl+ly+fyKn +++l+q+w+ f ng+sg +++++w+++lynl+f+ lp+ivl+++d+dvsa+
       EFC39377.1  785 VNASDYAIGQFRFLKRLLLVHGRWSYRRVSKLVLYCFYKNSLLYLTQLWYIFSNGYSGATVHDKWTIALYNLIFSGLPIIVLAVMDRDVSAD 876 
                       79****************************************************************************************** PP

  PhoLip_ATPase_C   93 lllkyPelYklgqknklfnlktfllwileglyqsliifflsylvlddssfsdgktndlqlfgtlvftalvlvvnlkvaletktwtliliili 184 
                       +++k+PelY++gqkn++fn k+f+ w++++l++sl++ff++y++l ds+f dg++ d +++g+++++++++v+ lk+++et++wt+++++++
       EFC39377.1  877 VAEKFPELYYQGQKNRFFNAKVFISWVVNSLFHSLVCFFVPYYCLVDSKFLDGHDIDPETIGIVIYSCVLVVISLKLCIETSSWTWVNVLIY 968 
                       ************************************************999***************************************** PP

  PhoLip_ATPase_C  185 lgsillyflflllyssllps.........ssefygvleelfsspsfwlvlllvvvvallpdllikvlkrt 245 
                        gs+l++ +f+++y s++           ++++++   ++f +p+f++++llv+++++++d+++k + r+
       EFC39377.1  969 TGSLLSWPAFIFVYGSIYYIfgypypvisEFYGITERWRIFLTPQFYMIVLLVTFMCCIRDIFWKGFVRM 1038
                       ****************99999******555555555789**************************99876 PP

>> PhoLip_ATPase_N  Phospholipid-translocating ATPase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.0   9.1     3e-27   8.9e-24       9      66 ..       3      60 ..       1      61 [. 0.94
   2 ?   -3.6   0.1       3.2   9.5e+03      39      55 ..     250     266 ..     247     270 .. 0.82
   3 ?   -2.6   0.0       1.5   4.6e+03      39      59 ..     415     435 ..     412     439 .. 0.82

  Alignments for each domain:
  == domain 1  score: 83.0 bits;  conditional E-value: 3e-27
  PhoLip_ATPase_N  9 nekkkyasNkIsTsKYtlltFlpknLfeqFrrvaNlYFLviailqliPqisplspvtt 66
                     n+++k+ +N+I+T+KYt+++Fl+knL+eqF+r+aN+YFL++a+lq+iP++sp++++t+
       EFC39377.1  3 NATNKFIDNSITTTKYTFYNFLFKNLYEQFHRFANCYFLFMAVLQTIPTLSPTGQFTA 60
                     45669***************************************************97 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 3.2
  PhoLip_ATPase_N  39 rrvaNlYFLviailqli 55 
                      +r+ N   L+++++q+i
       EFC39377.1 250 ERMINKLILLVLVVQII 266
                      78999999999999998 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.5
  PhoLip_ATPase_N  39 rrvaNlYFLviailqliPqis 59 
                      + + N+  L+ ++ ++iP+ s
       EFC39377.1 415 QDIQNFITLLAVCHTVIPERS 435
                      56789999**********876 PP

>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.1   0.0   2.1e-14   6.2e-11       4     163 ..      91     322 ..      89     334 .. 0.81

  Alignments for each domain:
  == domain 1  score: 42.1 bits;  conditional E-value: 2.1e-14
                   --EEEEE-TTS-EEEEGGG--TTSEEEEETT-B--SEEEEEEE-S.....EEE-TTTS---S-EE-............................... CS
  E1-E2_ATPase   4 pptakvirdgteeeidakelvpGDivllkagdrvpaDgrivegsa.....evdesaLTGEslpvek............................... 64 
                    + a+v+r+++ e+i  k++++GDiv++ +++  p+D ++v++s+      v++s+L GE     k                               
    EFC39377.1  91 NRIAHVLRGDKFEDIFWKDVKTGDIVKVDNKEPFPCDLILVSSSEsqglcYVETSSLDGETNLKIKrcrhetlelstpealdktrmivecekpnnrl 187
                   56899*************************************776666779****************************************999999 PP

                   .................G-TTEE-TT-EEEE.-EEEEEEEE-TTTSTTTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSS CS
  E1-E2_ATPase  65 .................ekgdmvfsGtvvvs.geakavVtatgedtelgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgks 143
                                    ++++ +  G++ ++ + +++v++ tg dt+l   +  ++e+ +k ++++++++kl+  + +v ++++l + +++++++++
    EFC39377.1 188 ykfegtmvlsngkklsiDTEQICLRGSSLKNtDFMIGVAIFTGHDTKL---MMNTKETPHKISKIERMINKLILLVLVVQIILVLSCDIALMVWTNF 281
                   998888888888888888888888888888866788899999999965...6777888899************998888888888777777776666 PP

                   TT.....................HHHHHHHHHHHHHS-TTH CS
  E1-E2_ATPase 144 la.....................eallralallvaaiPcaL 163
                    a                     +    +l ll+  iP+ L
    EFC39377.1 282 NAgawylfrdvvidseyiawngfKGYWTILILLTNLIPISL 322
                   65445555555555555555555555555555555555555 PP

>> Cation_ATPase  Cation transport ATPase (P-type)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.8   0.0   1.2e-13   3.5e-10       8      85 ..     432     523 ..     413     527 .. 0.82
   2 ?   -0.7   0.1      0.53   1.6e+03      38      38 ..     607     607 ..     553     650 .. 0.49

  Alignments for each domain:
  == domain 1  score: 39.8 bits;  conditional E-value: 1.2e-13
  Cation_ATPase   8 f..sensekdevkllGnktEsALlvlaekl............gldteelree....tkkvqeipFnssrKrmsvvlklepekkvrlyvKGApeiil 85 
                       s+n++++      +++E+AL+++a+ l            +++++e   +    ++ + +i+F+s+rKr+sv+++  pe+k+++++KGA  +i+
     EFC39377.1 432 PerSHNKPNEIIYQASSPDEAALVKAAKYLgiefinrttntvTIKIME---NeaieYQVLDIIEFSSDRKRQSVIVRD-PEGKLLIMTKGADSMIY 523
                    255788999999999***************777777777655444444...044459999*****************8.9***********99986 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.53
  Cation_ATPase  38 d 38 
                    d
     EFC39377.1 607 D 607
                    0 PP

>> Hydrolase  haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.0   5.9e-10   1.8e-06       1     149 [.     366     639 ..     366     649 .. 0.77
   2 !    7.5   0.0    0.0015       4.4     172     209 ..     732     770 ..     703     771 .. 0.77
   3 ?   -3.2   0.0       2.9   8.6e+03      78     134 ..    1062    1106 ..    1040    1111 .. 0.68

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 5.9e-10
                 SSEEEEESBTTTBCHHHHHHH...........HHHHH.................CHHHHHHHHHH...............HHCHHHHHHHHHHHHH... CS
                 xxxxxxxxxxxxxxxxxxxxx...........xxxxx.................xxxxxxxxxxx...............xxxxxxxxxxxxxxxx... RF
   Hydrolase   1 iktvvfDkdGTLttgepsved...........vivsa.................alalaaaletg...............sehpigkalvaaakar... 53 
                 i+ ++ Dk+GTLt+ ++   +           +++++                  + l a+ +t+               +  p  +alv+aak +   
  EFC39377.1 366 INYIFSDKTGTLTENKMDYDRpehvknnpnfqFFDERmndgawmneenaqdiqnFITLLAVCHTVipershnkpneiiyqASSPDEAALVKAAKYLgie 464
                 78899********9996666666555666666333337777777777777777744444444444555556666666699999*************554 PP

                 HHHHHHHHHETTTEHHHHTHHHHHHHHHCHHHHHHHHHHHHHHCHHHHHH................................................. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................................................. RF
   Hydrolase  54 sgaltgfatfigrgayaigkpewltaldippdlgaaigsaqsqgrtvall................................................. 103
                  ++ t +++     ++ i + e ++ +     + + i+   ++ r ++++                                                 
  EFC39377.1 465 FINRTTNTV-----TIKIMENEAIEYQ-----VLDIIEFSSDRKRQSVIVrdpegkllimtkgadsmiypllneesvekygpitlehldqfgneglrtl 553
                 444477777.....6777777777777.....5555555555555555555888888888888888888888888888888888888888888888888 PP

                 ..........................................TTHHHHHHHHHHTHHBHTTHHHHHHHHHHTTEEEEEEESSEHHHHH CS
                 ..........................................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 104 ..........................................qaralavftiadplkvkpeaaeavasLkaagievvlltgdnpetae 149
                                                           + + ++  +i+d+  + +++ +++++L++agi++++ltgd  eta 
  EFC39377.1 554 lcaqayldeeeyqqwhreyeeaktslenrqvkvemvgskiekNLQFVGATAIEDK--LQQGVGDTIYELRRAGINIWVLTGDKLETAI 639
                 8888888888888888888888888888888888999***888899999999999..***************************9985 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0015
                 TTTSHHHHHHHHHHHTST.GGGEEEEESSHHHHHHHHHT CS
                 xxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxx RF
   Hydrolase 172 akpspegkvaaireLqgk.peevamVGDgvnDaaalaaA 209
                   +sp++k  ++  ++ +  + ++++GDg nD+++++ A
  EFC39377.1 732 CRVSPKQKSDVVLLIKNNvDSITLAIGDGSNDVSMIQSA 770
                 5678888888888887444445*************9988 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 2.9
                  HHHHCHHHHHHHHHHHHHHCHHHHHHTTHHHHHHHHHHTHHBHTTHHHHHHHHHHTT CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   Hydrolase   78 taldippdlgaaigsaqsqgrtvallqaralavftiadplkvkpeaaeavasLkaag 134 
                  +                ++g  v +++++   v+++++ +kv++ a+  va+++ +g
  EFC39377.1 1062 ENF------------PFEEGLPVKMKKKKKFNVVELQEIKKVFETAVTSVAKFNYRG 1106
                  444............456677777778888888888888888888888888877666 PP

>> DUF4360  Domain of unknown function (DUF4360)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   1.7   9.2e-06     0.027      69     147 ..    1097    1177 ..    1061    1182 .] 0.74

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 9.2e-06
     DUF4360   69 favvsadyrGyasldagvtatfqatyyfsgdaeqa..stqttlsGplsg.dytltdevdvasavwspCgesailnintelrl 147 
                   +v++ +yrG+a  +++++++f  +yy   +++++  + + + ++ +++ + t+t+++ +++  +s+ +++ i+ni ++  +
  EFC39377.1 1097 TSVAKFNYRGFAFSQTEQQGDFLKQYYNGTSSTNNnnNGNNNNTNNTNNtNTTTTSNTGMNTLPNSA-NDNVIINISNDDII 1177
                  689999*********************9877655423333333333443366666666665544444.56688999887766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1238  (0.0690501); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.93u 0.31s 00:00:01.24 Elapsed: 00:00:00.51
# Mc/sec: 7002.61
//
Query:       EFC39378.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    9.8e-07   28.9   0.2    1.6e-06   28.3   0.2    1.2  1  APH             Phosphotransferase enzyme family
      1e-05   25.1   0.0    1.8e-05   24.2   0.0    1.4  1  Pkinase         Protein kinase domain
    1.4e-05   24.8   0.0    2.6e-05   23.9   0.0    1.4  1  Choline_kinase  Choline/ethanolamine kinase
  ------ inclusion threshold ------
      0.025   14.2   0.0      0.046   13.3   0.0    1.4  1  RIO1            RIO1 family
      0.036   14.3   0.1      0.063   13.5   0.1    1.4  1  DotA            Phagosome trafficking protein DotA
      0.037   13.2   0.3      0.061   12.5   0.3    1.3  1  Baculo_ODV-E27  Baculovirus occlusion-derived virus envelope 
       0.04   12.7   0.0       0.06   12.1   0.0    1.1  1  Pkinase_fungal  Fungal protein kinase


Domain annotation for each model (and alignments):
>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.2   6.2e-10   1.6e-06     165     198 ..     231     262 ..     215     266 .. 0.87

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 6.2e-10
                 -EEEE-SS-SGGGEEEC..TTEEEEE---TT-EE CS
         APH 165 ptvllHgDlhpgNllvdpddgrvtGviDfedagl 198
                 + +++H+D++p+N++ ++d+  +  +iD+++a++
  EFC39378.1 231 SLRFCHRDIRPDNVMRTDDGKLI--LIDWGFACA 262
                 578**************665555..*******97 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   0.0   7.2e-09   1.8e-05     117     153 ..     232     268 ..     225     282 .. 0.86

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 7.2e-09
                 TTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS CS
     Pkinase 117 kgiiHrDlKpeNiLidekgelKitDFGlakelesssk 153
                  +++HrD+ p+N++  ++g+l ++D+G+a+ +++++ 
  EFC39378.1 232 LRFCHRDIRPDNVMRTDDGKLILIDWGFACAINETTF 268
                 679****************************999764 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.0     1e-08   2.6e-05     141     176 ..     228     262 ..     202     274 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1e-08
                     HGG-EEEE-S--SGGGEEE.-CTTEEEE--GTT-EE CS
  Choline_kinase 141 lespvvfcHnDlqegNillnkeekklvlIDFEYagy 176
                      + ++ fcH D+ + N++  ++++kl+lID+ +a++
      EFC39378.1 228 VYDSLRFCHRDIRPDNVMR-TDDGKLILIDWGFACA 262
                     566799*************.9************985 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.8e-05     0.046      72     153 ..     185     261 ..     169     269 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.8e-05
                 S--EEEEETTEEEEE--EETTEEGGBHHHCG-HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETT.EEEE--GTTEE CS
        RIO1  72 vPkpielkrhvlvmefigedgvaapklkdveeeeeaeelyeevleemrklykeaglvHaDLSeyNvlvded.kvviIDvsQav 153
                 vP+ i + ++++v  +++  +v+   + +++      + +++++   r++y   +  H D+   Nv+ ++d k+++ID++ a 
  EFC39378.1 185 VPSGISIIKDCIVKFWVK--NVKNRIIPNIR---TPLSPLDTIII-FRVVYDSLRFCHRDIRPDNVMRTDDgKLILIDWGFAC 261
                 777777777777777777..55555555555...33334555555.8**********************999*******8665 PP

>> DotA  Phagosome trafficking protein DotA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   2.4e-05     0.063      12      55 ..     285     328 ..     281     359 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.4e-05
        DotA  12 fdaskllsafgsngkckgeyaeLCeWlggdatavkqvislings 55 
                 +d+++ + ++ ++  c++  ++ C W+++d+ ++ +v+ l +++
  EFC39378.1 285 LDQNTFIRPYKKEYDCESMLKTFCFWFDEDKIEILSVNRLKKAE 328
                 577888999***************************99886654 PP

>> Baculo_ODV-E27  Baculovirus occlusion-derived virus envelope protein EC27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.3   2.4e-05     0.061      51     170 ..     195     320 ..     189     354 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.4e-05
  Baculo_ODV-E27  51 alakyyvelvleltlPdlevlfrnkadlekvaavvysslafvnnrlvPlvvkfvd.mkfvvvedrdtsiPtePilftksl.hsdesvllcsvdra 143
                      + k++v+ v++   P+++       d+  ++ vvy sl f +  + P  v  +d  k++ ++        e   f   + ++ +  l c +d+ 
      EFC39378.1 195 CIVKFWVKNVKNRIIPNIRT-PLSPLDTIIIFRVVYDSLRFCHRDIRPDNVMRTDdGKLILIDWGFACAINETTFFAGIIsFCVDDYLGCVLDQN 288
                     56777777777777888887.445567778999****************99999978888887666666666666665432457899******** PP

  Baculo_ODV-E27 144 silkilekevdvea.....kfenddgkvrvak 170
                     + ++  +ke+d e+      f  d+ k++++ 
      EFC39378.1 289 TFIRPYKKEYDCESmlktfCFWFDEDKIEILS 320
                     *************9776554566666666654 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   2.3e-05      0.06     313     364 ..     219     265 ..     207     270 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 2.3e-05
  Pkinase_fungal 313 rDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsd 364
                      D I ++r  +   ++ HrDi  +N++ t     ++ k +LiD  +a+ +++
      EFC39378.1 219 LDTIIIFRVVYDSLRFCHRDIRPDNVMRT-----DDGKLILIDWGFACAINE 265
                     599************************99.....678999999999988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       503  (0.0280551); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2325.93
//
Query:       EFC39379.1  [L=449]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0044   15.9   0.6     0.0063   15.4   0.6    1.2  1  Androgen_recep  Androgen receptor
  ------ inclusion threshold ------
       0.14   12.7   0.4       0.36   11.4   0.4    1.6  1  Ribosomal_60s   60s Acidic ribosomal protein


Domain annotation for each model (and alignments):
>> Androgen_recep  Androgen receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.6     7e-07    0.0063     179     266 ..      53     137 ..      44     188 .. 0.69

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 7e-07
  Androgen_recep 179 dilaeastmqllqqqqqehhhqqhqhqqqqqqeaavvedsssgrareaagasasskdnylggtstisdsakelckavsvsmglgveal 266
                     d l e st q+ q    +hhhq+hq+qq++q    v   s    +   +   +ss       ts +sd +  l k   +s+ l v  +
      EFC39379.1  53 DHLLE-STTQIAQ-SYHHHHHQHHQQQQHDQLLDMVHLFS-PSNTELISFDFSSSSCSSSNNTSPLSDESPTLSKRSNLSLTLQVPDV 137
                     55555.4556544.44455666666655555555554444.4444444444445555556679******************9998655 PP

>> Ribosomal_60s  60s Acidic ribosomal protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.4     4e-05      0.36      57      82 ..     157     185 ..     132     190 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4e-05
                    XXXXXXXXXXXXXXXXXXX....XX--SS CS
  Ribosomal_60s  57 aaaaaaaaaaeekkkeeeee...Eeeddd 82 
                    ++ +++ + a + kkeeee    +ee+dd
     EFC39379.1 157 VKTEKKRKSAPKRKKEEEESicdDEEEDD 185
                    33444444444455555545698555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (449 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1667  (0.0929779); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.30s 00:00:00.92 Elapsed: 00:00:00.46
# Mc/sec: 2926.80
//
Query:       EFC39380.1  [L=374]
Description: conventional actin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   2.6e-140  467.7   0.0     1e-139  465.7   0.0    1.7  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  465.7   0.0  5.7e-144    1e-139       2     407 .]       2     374 .]       1     374 [] 0.98

  Alignments for each domain:
  == domain 1  score: 465.7 bits;  conditional E-value: 5.7e-144
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 +e   +V+DnGs++++aG+agedaP+av+psl+g+p++r+ +      + yvgdea++k++ +++++p+e+G++++wd++e++w+h++++el+v peeh
  EFC39380.1   2 EEHRPLVIDNGSGMCKAGFAGEDAPRAVFPSLIGRPKQRSIMVgvrykDAYVGDEAMSKKGTITLKYPIEHGIITNWDDIEKIWHHTFYNELRVGPEEH 100
                 67889**********************************9998****99************************************************** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvev 194
                  +llte+plnp+++rek+++i+fE+f+vpa+y+a +avls++asg+stg+v+DsG++v++ vp+ +Gy+L +ai r+dl+G++Lt++l+++l ++    
  EFC39380.1 101 GVLLTEAPLNPKANREKMTQIMFETFRVPAMYVAIQAVLSLYASGRSTGIVLDSGDGVSHTVPIDEGYALPQAILRLDLAGRDLTDYLMKILMER---- 195
                 **********************************************************************************************8.... PP

       Actin 195 tprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpeg..deeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligs 291
                                           ++s++t++e e++++iKe++c+v+ d+e+  +++++sss+e sYeLPDg++i++g+eRf++pE+LF+p+ ig+
  EFC39380.1 196 --------------------------GYSFNTSAECEIVRDIKEKLCYVAFDFETemKKASDSSSIEASYELPDGNVITVGNERFRCPEVLFQPKFIGM 268
                 ..........................9**************************98555566669*********************************** PP

       Actin 292 esaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvs 390
                 e a         gi+e ++++i +cd+d+r++L+ n+v++GG++++ g+ eR++kela++a++++++k++ap+ erkys+WiGGSiL+sl+tfq +w++
  EFC39380.1 269 EAA---------GIHETTFNSIGKCDIDIRKDLYVNVVLSGGTTMFGGIDERMNKELAAMAPASTRIKVVAPP-ERKYSVWIGGSILSSLSTFQPMWIT 357
                 *99.........*************************************************************.************************* PP

       Actin 391 kqEYeEqGssvverkck 407
                  +EYeE G  +v+rkc+
  EFC39380.1 358 AEEYEEAGCVIVRRKCF 374
                 ****************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       342  (0.0190752); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.27s 00:00:00.85 Elapsed: 00:00:00.46
# Mc/sec: 2419.52
//
Query:       EFC39381.1  [L=184]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (184 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       721  (0.0402142); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.48u 0.30s 00:00:00.78 Elapsed: 00:00:00.49
# Mc/sec: 1132.44
//
Query:       EFC39382.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.3e-12   46.9   0.6    2.7e-12   46.6   0.6    1.0  1  OST3_OST6  OST3 / OST6 family, transporter family


Domain annotation for each model (and alignments):
>> OST3_OST6  OST3 / OST6 family, transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.6   0.6   1.5e-16   2.7e-12     168     291 ..      23     151 ..       7     152 .. 0.87

  Alignments for each domain:
  == domain 1  score: 46.6 bits;  conditional E-value: 1.5e-16
   OST3_OST6 168 lrrklllkilksktlwavlslliillftsGymfnqIrgvpfva..kdekgg...isyfaggsqnQfgaEtqivallygllallvilLiklvpriknakv 261
                 l+ +++++    k+l+ vl l+ +++  sG ++  I+++p ++  +d +g+   +  +    ++Q+++E++  ++l ++ +l++i+L+ ++   + +++
  EFC39382.1  23 LKLPSIFEKGLPKMLVFVLLLASYFVICSGIVYDMINEPPSIGsrRDADGRvrpVAVLEYRLNAQYVIEGFSAGFLFTIGGLGFISLNWAADPSTTTRS 121
                 555566666667999***************************82245556544456777777**************************99999999*** PP

   OST3_OST6 262 qrvlvivllvlifllfslllslfriKnpgY 291
                 + ++  ++++li+++++ l+   ++K ++Y
  EFC39382.1 122 RYIFLGLGIFLIIIAYNTLIMFLKMKITNY 151
                 **************************9988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       611  (0.0340789); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.36s 00:00:00.89 Elapsed: 00:00:00.55
# Mc/sec: 843.29
//
Query:       EFC39383.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-11   45.3   0.0    2.8e-11   44.6   0.0    1.4  1  ADH_zinc_N_2     Zinc-binding dehydrogenase
    5.4e-10   39.1   0.1    9.9e-09   35.1   0.0    2.3  2  ADH_N            Alcohol dehydrogenase GroES-like domain
    6.2e-10   39.2   0.0    1.2e-09   38.3   0.0    1.5  1  ADH_zinc_N       Zinc-binding dehydrogenase
    5.7e-06   26.3   0.0    7.6e-06   25.9   0.0    1.1  1  DUF2855          Protein of unknown function (DUF2855)
      0.003   17.4   0.0     0.0062   16.4   0.0    1.5  1  ADH_N_2          N-terminal domain of oxidoreductase
  ------ inclusion threshold ------
      0.011   15.5   0.1      0.024   14.4   0.1    1.5  1  Eno-Rase_NADH_b  NAD(P)H binding domain of trans-2-enoyl-CoA 


Domain annotation for each model (and alignments):
>> ADH_zinc_N_2  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.6   0.0   9.4e-15   2.8e-11       1     133 []     202     331 ..     202     331 .. 0.79

  Alignments for each domain:
  == domain 1  score: 44.6 bits;  conditional E-value: 9.4e-15
                   TT-SEEEETT.STTHH....HHH-TT-EEEEEES-H..HHHH.HHHHHHE..EEEEEEEE----.S-EEE-CHHHCTTT-EEEE--GGG...-.-HH CS
  ADH_zinc_N_2   1 lGAdevidyr.tedfe....aatggegvDvvldtvg..gealleaslkvl..pggGrlvsiggpplsaallkpakkrkgrsvkyeflfsmkasaqad 88 
                   lGAd+v+dy+  +++     ++++ + +D+vld vg  +e++   s+++l  + + ++v+i    ++++++ + +    +s +++ l  ++++ + +
    EFC39383.1 202 LGADQVLDYTkGKEYLthelESLK-GTFDIVLDFVGsyQEYY---SIELLkqDEESQFVTIVH--TPQGISGKVF----GSERAKNLY-AERD-GDQ 286
                   8*********64444479988885.56*********755555...889998655699****96..3566666666....778888888.6888.899 PP

                   HHHHHHHHHHHHH----EE.EEEEGGGHHHHHHHHHSS--SSEEEE CS
  ADH_zinc_N_2  89 ileelaalieeGklrpvvd.rvfpleeaaeAhrylesgrarGKiVl 133
                    l+ ++++++e  l   +  + ++l++a +A +  es+r++GKi+l
    EFC39383.1 287 -LAVILKWLSESGLWKDIPiHILSLDQASQAQKMSESNRTVGKIIL 331
                   .*******98776654444146**********************98 PP

>> ADH_N  Alcohol dehydrogenase GroES-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.1   0.0   3.3e-12   9.9e-09       2      61 ..      37      95 ..      36     100 .. 0.94
   2 ?    2.1   0.1     0.057   1.7e+02      90     106 ..      99     116 ..      93     118 .. 0.77

  Alignments for each domain:
  == domain 1  score: 35.1 bits;  conditional E-value: 3.3e-12
                TEEEEEEEEEEE-HHHHHHHTTSTTTTSSSSEE---EEEEEEEEESTT-CS--TT-EEEE CS
       ADH_N  2 gevlikvkaagiCgsDlhilkggkelevklplilGHEivGeveevgpevkklkvGdrVvv 61
                +++l++ ++ag++  D ++ +    + +++p ilG +++G+v+++g++v+k+k+Gd V+ 
  EFC39383.1 37 DDILVRNQYAGVNPLDCKVRQY-GFYINSYPTILGVDFSGIVVATGSKVTKFKIGDSVCG 95
                79******************99.69*********************************86 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.057
                 S.S-SSSBSEEEECGGGE CS
       ADH_N  90 s.ldGgfaeyvvvpekkl 106
                 + ++G++++yvv++e+++
  EFC39383.1  99 ThIRGTYSQYVVCSESQA 116
                 2599*********98875 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3   0.0   3.9e-13   1.2e-09       1      81 [.     169     249 ..     169     275 .. 0.80

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 3.9e-13
                 HHHHHHHHHHH.HTT-EEEEEESSHHHHHHHHHTTESEEEET...TTCHHHHHHHHHTTTSSEEEEEESSCSHHHHHHHHHCEEE CS
  ADH_zinc_N   1 gvGlaavqlAk.alGaeviavdsseeklelakklGadeviny...keadlverikeltggegvdvvfecvGsgatleaalkllkp 81 
                 gvG+ ++ lAk  ++ae i++ ss++++++++klGad+v++y   ke  l  ++++l g   +d+v+++vG       +++llk 
  EFC39383.1 169 GVGMSGILLAKnYFNAEKIVTISSAKNADFVRKLGADQVLDYtkgKE-YLTHELESLKG--TFDIVLDFVG-SYQEYYSIELLKQ 249
                 8**********889999999999999****************63333.58888888884..9*********.3333345555555 PP

>> DUF2855  Protein of unknown function (DUF2855)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.0   2.5e-09   7.6e-06      91     221 ..      99     237 ..      77     264 .. 0.77

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 2.5e-09
     DUF2855  91 aalmpiYnrylrvsedpay.esde.eealtallrplfetsflledflfd.......dadlsgakvvvllsASsKTAlslayllrkrrkaeegplklvgl 180
                 ++ +  Y +y ++se++a+ ++++ +++  a + + f t+f +  fl++       ++ l+g  +v++++ S+  ++s   l+++  +a     k+v +
  EFC39383.1  99 THIRGTYSQYVVCSESQAAlNPESiSHQVAASCPVTFLTAFQC--FLRHpssksgqKDSLRGK-QVLIIGGSGGVGMSGILLAKNYFNA----EKIVTI 190
                 567789************86555414555556666799**987..555555778855566666.*************988777777775....89**** PP

     DUF2855 181 TSaknrafveslglydkvvsYddlesleaa.....kkv..vivDfagr 221
                 +Sakn++fv++lg  d+v++Y++ ++  +      k +  +++Df g+
  EFC39383.1 191 SSAKNADFVRKLG-ADQVLDYTKGKEYLTHeleslKGTfdIVLDFVGS 237
                 ************9.599****998776655555543335588888776 PP

>> ADH_N_2  N-terminal domain of oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.0   2.1e-06    0.0062      22      91 ..      28      96 ..      14     115 .. 0.80

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.1e-06
     ADH_N_2 22 eeelpelkdGevlvralylSvDPymRgrmndaksyve..pvelgdvmrggavgeVveSknpdfkvGdlVvgl 91
                + +lp+l+++++lvr++y +v P     +++   y++  p+ lg    g +v+  + Sk  +fk Gd V+g 
  EFC39383.1 28 KFDLPQLNEDDILVRNQYAGVNPLDC-KVRQYGFYINsyPTILGVDFSGIVVA--TGSKVTKFKIGDSVCGC 96
                4589*****************99753.344445555546999*******9999..599**********9885 PP

>> Eno-Rase_NADH_b  NAD(P)H binding domain of trans-2-enoyl-CoA reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.1   8.1e-06     0.024      39      68 ..     157     186 ..     142     196 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 8.1e-06
                      .-SEEEEESTSSHHHHHHHHHHHHSS--EE CS
  Eno-Rase_NADH_b  39 gpkkvLviGaStGYGLAsriaaafgagadt 68 
                        k+vL+iG+S G G++  + a+   +a+ 
       EFC39383.1 157 RGKQVLIIGGSGGVGMSGILLAKNYFNAEK 186
                      47**************98777766666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       595  (0.0331865); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 2026.07
//
Query:       EFC39384.1  [L=219]
Description: adenylate kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.6e-54  182.1   0.0    7.9e-54  181.9   0.0    1.0  1  ADK             Adenylate kinase
    3.6e-24   85.7   0.0    6.3e-24   84.9   0.0    1.3  1  AAA_17          AAA domain
    8.3e-15   54.5   0.0    1.5e-14   53.6   0.0    1.5  1  ADK_lid         Adenylate kinase, active site lid
    1.2e-06   29.0   0.0    4.6e-06   27.0   0.0    1.8  2  Hydin_ADK       Hydin Adenylate kinase-like domain
    1.2e-05   25.6   0.0    1.9e-05   24.9   0.0    1.3  1  AAA_33          AAA domain
     0.0034   17.9   0.0      0.011   16.3   0.0    1.8  1  AAA_18          AAA domain
  ------ inclusion threshold ------
      0.017   14.8   0.0      0.026   14.2   0.0    1.2  1  Cytidylate_kin  Cytidylate kinase


Domain annotation for each model (and alignments):
>> ADK  Adenylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.9   0.0   3.1e-57   7.9e-54       2     150 ..      11     195 ..      10     196 .. 0.99

  Alignments for each domain:
  == domain 1  score: 181.9 bits;  conditional E-value: 3.1e-57
                 EESTTSSHHHHHHHHHHHHTSEEEEHHHHHHHHHHCT-HHHHHHHHHHHTTSS--HHHHHHHHHHHHHCHGTTTEEEEESB-SSHHHHHHHHHHHHHHT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK   2 lGaPgaGKGtqaeklvkkyglahlstGdllRaevksgtelGkeakevmdkgelvpdevvvklvkeelekedkkkgfllDGfPRtveqaealeelleeek 100
                  G+Pg+GKGtqa +l k+y+++hlstGd+lR++v+++te+G +ak+ +d+gelv+d++v++++++++ +++++ gf+lDGfPRtv+qaeal+++l++++
  EFC39384.1  11 FGPPGSGKGTQAIQLSKEYEACHLSTGDMLRDAVRNQTEMGLKAKAKIDAGELVSDDIVIGIIRDSIGSPACRYGFILDGFPRTVPQAEALDQMLSDRN 109
                 6************************************************************************************************** PP

                 SEESEEEEEE--HHHHHHHHHT....................................GSHHHHHHHHHHHHHHHHHHHHHHHHTT CS
                 xxxxxxxxxxxxxxxxxxxxxx....................................xxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK 101 vkldlvleldvpeevlveRltg....................................DneetvkkRletykkqtkplidyykkkg 150
                 ++++ vl+l v++ev+v+R++g                                    Dne+ +++Rl+ty+  +  ++ yy++kg
  EFC39384.1 110 TSVEHVLNLGVSDEVVVKRVSGrlthltsgrtynkffkppkvdglddvtgepltqrpdDNENIIRNRLKTYHGYADKVLGYYNQKG 195
                 ***********************************************************************************986 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.9   0.0   2.5e-27   6.3e-24       1     128 [.      11     141 ..      11     144 .. 0.90

  Alignments for each domain:
  == domain 1  score: 84.9 bits;  conditional E-value: 2.5e-27
                 EE-TTSSHHHHHHHHHHHHTEEEEEHHHHHHHHHHTT.TS.HSSHHHHCTSHHHHHHHHHHHHHHHHHHHHHSSEEEEEE-SEEEETTEEEESSHHHHH CS
      AAA_17   1 lGgPGsGKgtqceklvekygfthlsaGdllreeakrg.gl.akardemrklpleekkelqkeaaekiaeeakkkgvlvdghprikeqagfldglpkevl 97 
                 +G+PGsGKgtq+ +l ++y+  hls+Gd+lr+ ++++ ++  ka+ +++ ++l+ ++ +  ++ ++i   a++ g+++dg+pr+  qa++ld++ ++  
  EFC39384.1  11 FGPPGSGKGTQAIQLSKEYEACHLSTGDMLRDAVRNQtEMgLKAKAKIDAGELVSDDIVIGIIRDSIGSPACRYGFILDGFPRTVPQAEALDQMLSD-- 107
                 6******************************8887775334599***************************************************97.. PP

                 HHH..SEEEEEE--HHHHHHHHHHH.T..TST-T CS
      AAA_17  98 eelkpdaiilleadpeeilerrlkd.r..trgrd 128
                 ++ ++++++ l +++e++++r+  + +  t+gr+
  EFC39384.1 108 RNTSVEHVLNLGVSDEVVVKRVSGRlThlTSGRT 141
                 66777****************8777522478886 PP

>> ADK_lid  Adenylate kinase, active site lid
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   53.6   0.0     6e-18   1.5e-14       1      36 []     132     167 ..     132     167 .. 0.96

  Alignments for each domain:
  == domain 1  score: 53.6 bits;  conditional E-value: 6e-18
                 EEE-TTT--EEETTT.B--SSTTB-TTT--.-B--GG CS
     ADK_lid   1 RrvCpkCGrsYhvvf.npPkveglCDkCGepLvqRsD 36 
                 R+++  +Gr+Y+ +f +pPkv+gl+D++GepL+qR+D
  EFC39384.1 132 RLTHLTSGRTYN-KFfKPPKVDGLDDVTGEPLTQRPD 167
                 99**********.766********************9 PP

>> Hydin_ADK  Hydin Adenylate kinase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.0   1.8e-09   4.6e-06       4      50 ..      10      55 ..       8      58 .. 0.91
   2 ?   -1.2   0.1       0.8     2e+03     173     197 ..      66      90 ..      62      91 .. 0.90

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 1.8e-09
   Hydin_ADK  4 vhGaPlsGKtatavtLakkYeaAlltiDsvvleAisdgnssaGlrAr 50
                  G+P sGK + a++L+k+Yea  l+  +++ +A+ ++ ++ Gl+A+
  EFC39384.1 10 FFGPPGSGKGTQAIQLSKEYEACHLSTGDMLRDAVRNQ-TEMGLKAK 55
                57*********************************886.67899986 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.8
   Hydin_ADK 173 edllveIlsERlqlndCyrGvvfDg 197
                 +d+++ I+ + +    C  G ++Dg
  EFC39384.1  66 DDIVIGIIRDSIGSPACRYGFILDG 90 
                 899999****9*99**********9 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.9   0.0   7.4e-09   1.9e-05       3     119 ..       9     133 ..       8     143 .. 0.73

  Alignments for each domain:
  == domain 1  score: 24.9 bits;  conditional E-value: 7.4e-09
      AAA_33   3 llvGlpGsGKstlaerllkklgavllssdtlrr.rlfg.....tdqqskt..dytr....vldr.lyqilnelarkalsagrnvildatnlsrrerarf 88 
                 ++ G+pGsGK t a +l k+  a++ls+ +++r ++++           +    ++    v+d+ +++i+++ +    + ++++ild   ++  + +++
  EFC39384.1   9 VFFGPPGSGKGTQAIQLSKEYEACHLSTGDMLRdAVRNqtemgL-----KakAKIDagelVSDDiVIGIIRDSIG-SPACRYGFILDGFPRTVPQAEAL 101
                 799************************98877736666433221.....22222221122333356667777774.46778999999999999999999 PP

      AAA_33  89 lklarrlgvpvri.vvvetdeetlkeRlakRa 119
                 ++++++ +  v+  + + +++e+  +R+  R 
  EFC39384.1 102 DQMLSDRNTSVEHvLNLGVSDEVVVKRVSGRL 133
                 99999888887551678999999999999885 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   4.2e-06     0.011       3     114 ..      10     133 ..       9     144 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 4.2e-06
      AAA_18   3 ltGtpGvGKttlakeLskrl.gf....gvnlrdvakenglllevdpealdeskrldedkldklldaleenssaleegknlvidghlaeleseaakdikk 96 
                   G+pG+GK t a  Lsk+  ++    g+ lrd +++        ++++d  + + +d +  +++   ++++        ++dg++    +++a d   
  EFC39384.1  10 FFGPPGSGKGTQAIQLSKEYeAChlstGDMLRDAVRNQTEMGLKAKAKIDAGELVSDDIVIGIIRDSIGSPA---CRYGFILDGFPRTVPQAEALDQML 105
                 57****************976669999999999999865555555556666666666664444444444433...223347777777666666666555 PP

      AAA_18  97 ..........vvLtaspeelleRlekRg 114
                             L +s+e+  +R++ R 
  EFC39384.1 106 sdrntsvehvLNLGVSDEVVVKRVSGRL 133
                 6777777777778888888888887776 PP

>> Cytidylate_kin  Cytidylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0     1e-05     0.026       5      35 ..      12      42 ..      10      70 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1e-05
                    -STTSSHHHHHHHHHHHHT-EEEEHHHHHHH CS
  Cytidylate_kin  5 GPagsGKssvaralaeklglkyldtgalYRa 35
                    GP gsGK++ a +l+++ ++  l+tg + R 
      EFC39384.1 12 GPPGSGKGTQAIQLSKEYEACHLSTGDMLRD 42
                    9***************************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       384  (0.0214178); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1279.59
//
Query:       EFC39385.1  [L=465]
Description: poly (ADP-ribose) glycohydrolase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.5e-99  332.8   0.0    3.2e-99  332.4   0.0    1.1  1  PARG_cat    Poly (ADP-ribose) glycohydrolase (PARG)
  ------ inclusion threshold ------
      0.092   13.0   0.1        2.9    8.1   0.0    2.9  3  Ca_chan_IQ  Voltage gated calcium channel IQ domain


Domain annotation for each model (and alignments):
>> PARG_cat  Poly (ADP-ribose) glycohydrolase (PARG)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  332.4   0.0  3.6e-103   3.2e-99       5     335 ..      93     418 ..      90     420 .. 0.97

  Alignments for each domain:
  == domain 1  score: 332.4 bits;  conditional E-value: 3.6e-103
    PARG_cat   5 esekffeevlpklaklalklpslleke.lrlLkqqesesvtlsqeqiaallanaFfclfprqernkseekklpsinfdrlfssessseskaeklkcllh 102
                 +s++f+++v+p++a+l+lk +++l+k+ +++Lk++es+++t+s+  +a++lan+Ffc++ r +  +   k +psin+d+++ +  +++ + +k  +ll+
  EFC39385.1  93 NSDDFLSTVIPFIAHLVLKSEDYLPKQsIQYLKKGESKTLTISKLGAACILANSFFCTWYRLSY-DPLWKYFPSINYDEMYGKFPNFRPQFAKTMMLLN 190
                 6899******************999888*********************************777.8899**************999************* PP

    PARG_cat 103 YFervt......ekepegvvsferkvlskkekiedwsksekklskveveseglIedqskgalqvdFAnkyiGGgvlsrGcvQEeirflinPElivsmLf 195
                 YF rv       +++p+  +sf+r++l+    i++++ s+ +l++v+v+s+g+I d s++a+q+dFAnk+iGG ++s GcvQEei f ++PE+ +++Lf
  EFC39385.1 191 YFARVHksfadySSNPNLGISFTRHYLTP---IPSFEYSDLPLCDVHVNSQGSIAD-SHDAVQIDFANKFIGGASISFGCVQEEIEFSLCPEMNIARLF 285
                 ******99*999999**************...************************.9***************************************** PP

    PARG_cat 196 teklednealvivgaerfssytGYassfrfagdyvdktprdslgrrkteivaiDAlefkkeekekqykkekilRelnKAyvgFksqekekeeeekvgia 294
                 ++++ d+e+++i+gae++s+++GYa s+ +ag+++d  ++ds+g+  ++  aiDAl f+k +  +q++ke+i+Re+ K+++gF+s++++++      i+
  EFC39385.1 286 CHVMGDRESILITGAEQYSKHKGYAFSLDYAGNFID-LNKDSNGNSLKQTSAIDALIFNKLNFLSQWEKETIDREIIKSLSGFSSSKTMDK------IS 377
                 ************************************.899999*9***************************************9999988......** PP

    PARG_cat 295 TGnWGCGaFgGdpeLKaliQllAasqagrelvyytfgdkel 335
                 TGnWGCGaF Gd eLKa+iQ+++as+a+++lvyy+f++ke+
  EFC39385.1 378 TGNWGCGAFLGDVELKAIIQVISASLAQKSLVYYSFQRKEV 418
                 *************************************9987 PP

>> Ca_chan_IQ  Voltage gated calcium channel IQ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0     0.054   4.8e+02      52      73 ..     126     147 ..     109     149 .. 0.79
   2 ?   -1.9   0.0      0.44     4e+03      30      49 ..     358     377 ..     342     386 .. 0.79
   3 ?    8.1   0.0   0.00033       2.9      26      73 ..     389     448 ..     371     453 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.054
  Ca_chan_IQ  52 ekekdelTVGkiYAallildyy 73 
                 ++e++ lT+ k+ Aa ++++ +
  EFC39385.1 126 KGESKTLTISKLGAACILANSF 147
                 344899*********9998876 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.44
  Ca_chan_IQ  30 rkeikkiwpslskklldllv 49 
                 r++ik++    s+k++d++ 
  EFC39385.1 358 REIIKSLSGFSSSKTMDKIS 377
                 88899999999999999885 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.00033
  Ca_chan_IQ  26 deelrkeikkiwpslskklldllvppeke............kdelTVGkiYAallildyy 73 
                 d el+++i+ i  sl++k l +   + ke            k+ +TVG +Y +ll +  +
  EFC39385.1 389 DVELKAIIQVISASLAQKSLVYYSFQRKEvevlaplvedlnKQGITVGALYQSLLKVKQF 448
                 66777777777777777766666666555677777777788999**********977666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (465 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       442  (0.0246528); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2876.84
//
Query:       EFC39386.1  [L=298]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-06   27.4   0.0    1.5e-05   25.1   0.0    2.0  1  NUDIX     NUDIX domain


Domain annotation for each model (and alignments):
>> NUDIX  NUDIX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.1   0.0   8.3e-10   1.5e-05      15      85 ..      37     139 ..      31     204 .. 0.56

  Alignments for each domain:
  == domain 1  score: 25.1 bits;  conditional E-value: 8.3e-10
                 SEEEEEEES..SSSTTT.EESSEEECBT.....TSHHHHHHHHHHHHHHS.EEE.EEE......................EEEEEEEEEEEEEEEEEE. CS
       NUDIX  15 gevLlvrrs..kkpfpg.WelPgGkvep.....gEtpeeAArREleEEtG.lea.ell......................ellgrlhylapydgpygd. 80 
                  ++Ll++r+   k f+   ++PgG +e      g++ + +A+RE +EE+G l + e +                      +                  
  EFC39386.1  37 YKLLLLERNesSKSFAKsSTFPGGALETtdgqlGDEDKVCAIRESFEEAGfLVCkEKVpvkeimqnnwrnvvhneanqfkQ----------------Ml 119
                 569*****977444444367********9*999665559***********7566566655544444222222222222221................02 PP

                 ...............EEEEE CS
       NUDIX  81 ...............eheil 85 
                                +++i+
  EFC39386.1 120 sqynltldldslipyQRWIT 139
                 34444444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (298 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       519  (0.0289475); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 1725.67
//
Query:       EFC39387.1  [L=749]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.1e-32  110.0   0.0    2.6e-31  108.1   0.0    2.1  2  Beta-Casp        Beta-Casp domain
    4.1e-22   79.2   0.3    6.1e-22   78.6   0.3    1.2  1  Lactamase_B      Metallo-beta-lactamase superfamily
    1.2e-19   70.6   0.1      1e-18   67.5   0.0    2.6  3  Lactamase_B_6    Metallo-beta-lactamase superfamily domain
    1.3e-16   60.2   0.0    2.8e-16   59.2   0.0    1.6  1  RMMBL            Zn-dependent metallo-hydrolase RNA specifici
    1.4e-16   60.7   1.6    9.6e-16   58.0   1.0    2.6  2  CPSF73-100_C     Pre-mRNA 3'-end-processing endonuclease poly
    1.5e-07   31.1   0.4      4e-07   29.7   0.4    1.7  1  Lactamase_B_2    Beta-lactamase superfamily domain
    6.3e-05   22.9   0.2    0.00034   20.5   0.2    2.1  1  Lactamase_B_3    Beta-lactamase superfamily domain
     0.0049   16.1   0.0      0.013   14.7   0.0    1.7  2  Beta_lactamase3  Putative beta-lactamase-like family


Domain annotation for each model (and alignments):
>> Beta-Casp  Beta-Casp domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.1   0.0   1.2e-34   2.6e-31       1     110 []     273     394 ..     273     394 .. 0.92
   2 ?   -3.8   0.0       6.9   1.5e+04      58      89 ..     432     463 ..     413     466 .. 0.62

  Alignments for each domain:
  == domain 1  score: 108.1 bits;  conditional E-value: 1.2e-34
                 HHHHHHHH..HCTT...TTS-S.-EEEEE-HHHHHHHHHGGGGGGE-SHH....HHH..H...HH.................HS-SSEEEEES-TTSSS CS
   Beta-Casp   1 aqellylLeelwkekk.ledlk.lpiyldsplaskatevYkeyaeveakslewmesk..ke.eln.................sskgpkvilassgmleg 77 
                 aqell++L+e+w+ ++ l   + +piy++s+la+k+++++++y       +++m++k  k+ +++                 +++gp+vi+as+gml++
  EFC39387.1 273 AQELLLILDEFWETHQdL---QhIPIYYASSLAKKCMTIFQTY-------INMMNDKirKQfDIHnpfvfkhisnlrsiedfQDNGPCVIMASPGMLQS 361
                 7*************9844...338*******************.......99*****9443544489***************999************** PP

                 SHHHHHHHHHTTSTTSEEEESS---TTSHHHHH CS
   Beta-Casp  78 GrsrellkklledprntvilvgyqaegTlgrkl 110
                 G s+el++ +++d++n vi+ gy++ gTl++k+
  EFC39387.1 362 GLSKELFELWCQDAKNGVIIAGYSVDGTLAKKI 394
                 ******************************997 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 6.9
                 .HHHS-SSEEEEES-TTSSSSHHHHHHHHHTT CS
   Beta-Casp  58 elnsskgpkvilassgmlegGrsrellkklle 89 
                  + + k p +il+    ++  r ++ l++  +
  EFC39387.1 432 FIGTIKPPHIILVHGDLANCNRLKHSLQSKFT 463
                 33456678888888887788888887776555 PP

>> Lactamase_B  Metallo-beta-lactamase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.6   0.3   2.7e-25   6.1e-22       4     162 ..      50     218 ..      47     254 .. 0.95

  Alignments for each domain:
  == domain 1  score: 78.6 bits;  conditional E-value: 2.7e-25
                  CSSEEEEEEETTCEEEES--SCHHHHHHHHHHHHHTSGGGGEEEEE-SBSSHHHHTTGGGCTTHHCCEETCCEHHHHCCHCHHHHHHHHHCCHH.... CS
  Lactamase_B   4 dpvnsyliegdggviLiDtGtsteaaraalelaalglkpkdvdavilTHlHlDHiGglgglveatdvpvgavaeeapalfmeeaddaasrkgll.... 97 
                  ++ +++l++ +g+++L+D+G++++++ +a++++   ++p ++d v++TH+HlDH+G+l++++e+t++  ++   +  + ++  + +++++ ++     
   EFC39387.1  50 VGRSAVLLQFKGKTVLFDCGIHPAFTGMASLPFFDTIEPSEIDLVLVTHFHLDHCGALPYFTEHTNFQGRVFMTHPTKAIYKLLLTDFVKVSDVhvdd 147
                  67899*************************************************************************************9999**** PP

                  ......TTCHCGCCEEEEETTTEECCCTEEEEEHECTTSTSCCEEEEEETTCCEEEECTTTSSHHCCCCCC CS
  Lactamase_B  98 ......lagvsadkpdvdeeeldgnaggrralyvtggpghghghgvveygggkvlftGDallagetgridl 162
                           +s +k +  +  +++++ g++++    g++ g+  + ve+ g +vl+tGD++ ++++ +++ 
   EFC39387.1 148 qlfteqNLLDSLKKIELIDYHQELEHNGIKFWCYNAGHVLGAAMFMVEIAGVRVLYTGDFSRQPDRHLLGA 218
                  ******99******************************************************999988776 PP

>> Lactamase_B_6  Metallo-beta-lactamase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.74   1.7e+03     128     144 ..      36      52 ..      21      54 .. 0.82
   2 !   67.5   0.0   4.6e-22     1e-18       1     175 [.      56     220 ..      56     232 .. 0.89
   3 ?   -2.7   0.0       1.5   3.4e+03      23      78 ..     423     476 ..     411     505 .. 0.65

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.74
  Lactamase_B_6 128 ldgltitaynaGhtlGG 144
                     ++l++t++ aG+ +G 
     EFC39387.1  36 GEKLVVTPLGAGNEVGR 52 
                    589***********995 PP

  == domain 2  score: 67.5 bits;  conditional E-value: 4.6e-22
  Lactamase_B_6   1 lLeldnvkiLlDvGwdeskvslesalkelekvi.ptvdliLLshatlehlGayallyakfksklllnipvyatlpvvkLGrvslldlyaskgllgp 95 
                    lL++ + ++L D+G +  +  +  +l + +++  +++dl+L++h  l+h Ga++++     ++   + +v+ t+p++++ +++l+d ++ +++   
     EFC39387.1  56 LLQFKGKTVLFDCGIHPAFTGM-ASLPFFDTIEpSEIDLVLVTHFHLDHCGALPYFT----EHTNFQGRVFMTHPTKAIYKLLLTDFVKVSDVH-- 144
                    79999************97665.5777777764269****************87655....4566799*******************9999775.. PP

  Lactamase_B_6  96 edseeleledideafdkiktlkYsQklelkskldgltitaynaGhtlGGtiWkiskesekivYavdwnhakeshLngaal 175
                    +d++ ++ ++   + +ki+ + Y+Q+le     +g+ +  ynaGh+lG++++ ++    +++Y  d++ + ++hL ga++
     EFC39387.1 145 VDDQLFTEQNLLDSLKKIELIDYHQELE----HNGIKFWCYNAGHVLGAAMFMVEIAGVRVLYTGDFSRQPDRHLLGAET 220
                    88899********************964....479****************************************99976 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.5
  Lactamase_B_6  23 esalkelekviptvd..liLLshatlehlGayallyakfksklllnipvyatlpvvkL 78 
                    +s+ ++ e+ i t+   +i+L h +l+    +    ++ + + +++ +vya++  + +
     EFC39387.1 423 HSDKAQTEEFIGTIKppHIILVHGDLANCNRL---KHSLQ-SKFTDSKVYAPKNCTSI 476
                    55555666666555433677888887777754...33333.44578888888776665 PP

>> RMMBL  Zn-dependent metallo-hydrolase RNA specificity domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.2   0.0   1.2e-19   2.8e-16       1      62 []     408     470 ..     408     470 .. 0.94

  Alignments for each domain:
  == domain 1  score: 59.2 bits;  conditional E-value: 1.2e-19
       RMMBL   1 tipvkarieeidfSgHadknellelirklkprnvilvHGeeeatsalarllkeee.gidvfiP 62 
                 t+p+++++ +i+fS+H+dk+++ e+i ++kp+++ilvHG+   + +l+  l++++ + +v++P
  EFC39387.1 408 TVPLRMSVRTISFSAHSDKAQTEEFIGTIKPPHIILVHGDLANCNRLKHSLQSKFtDSKVYAP 470
                 69*************************************************999855888776 PP

>> CPSF73-100_C  Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.52   1.2e+03     147     193 ..     450     494 ..     421     499 .. 0.81
   2 !   58.0   1.0   4.3e-19   9.6e-16       3     217 .]     503     731 ..     501     731 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.52
  CPSF73-100_C 147 rlerllllLeaqFGedkvielpkepvpgvevkv.dkkeakidletleV 193
                   +++rl+  L+++F ++kv +  +++  ++++ + ++k ak+ l +l V
    EFC39387.1 450 NCNRLKHSLQSKFTDSKVYA--PKNCTSINIMFqGEKRAKV-LGQLAV 494
                   67899999******999654..3467788888867888888.666666 PP

  == domain 2  score: 58.0 bits;  conditional E-value: 4.3e-19
  CPSF73-100_C   3 vsGvLVqkdfklsllapeDLreytgLstttitqkqrlpls..asi.ellkwaleqlfgdve...........eleekekkk................ 69 
                   ++G+L   +f++ ll+++DL+ y++   + ++q++ +pl+  +++ +l+++  ++++ + e                   +                
    EFC39387.1 503 INGILLHHNFQHLLLNEKDLKLYSDVCCSGVKQTLLVPLNdtVPYeQLIRSVFSNVTLETEptevqvkseimD-------Ttddkkedikytpiefa 592
                   89*************************************8334442355655555555555665556665441.......03444566788888888 PP

  CPSF73-100_C  70 .......tllvmgcvtvrveskgev...eleWesnllnDmiADsviavllsvesspasvkrsskkhshshkekleeknshaklskeerlerllllLe 156
                          ++ + g v+++++ +++    ++eW s++ nD+i Ds++ ++l  ++s ++                     ++ +++ ++l ++  +L+
    EFC39387.1 593 aeaakpiVIFIDGVVRIELRLQEKTpcgVIEWPSSAANDTIVDSICNLILYTDKSFHESL------------------LDEGKDELKMLYCIQQMLK 671
                   888887667777999*999987777899*************************9988655..................678899999********** PP

  CPSF73-100_C 157 aqFGedkvielpkepvpgve.vkv.dkkeakidletleVecesevlkdrveavveravetvap 217
                   ++FGe++  +l++  + ++  v   dk  +k++     +ec +e  +  +e v++r+   ++p
    EFC39387.1 672 EHFGECTC-RLSE--NREIDvVDKeDKVIVKVSSMGEIIECVEERNRGFLEIVIRRIFMSMFP 731
                   ******93.3433..445442322366667776666678*****************9887765 PP

>> Lactamase_B_2  Beta-lactamase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.7   0.4   1.8e-10     4e-07       2     165 ..      63     233 ..      62     253 .. 0.67

  Alignments for each domain:
  == domain 1  score: 29.7 bits;  conditional E-value: 1.8e-10
                    EEEES--TT..HHHH.HTCGGS--SSS--..SEEEEE-SS--HHHHGGGGCCCC...C--EEEEEEEEHHHHHHCCTTCGHHHCHTT......... CS
  Lactamase_B_2   2 riLiDagpd..lrqq.alralqPvelrdelppidaVllthaHyDHlaglltlre...lrpkklplyapkgvlavleanfvylaleee......... 82 
                     +L+D+g    + +   l    P     e+++id+Vl+th H DH+  l+ + e   ++++ +  + +k +++ l + fv   + +          
     EFC39387.1  63 TVLFDCGIHpaFTGMaSL----PFFDTIEPSEIDLVLVTHFHLDHCGALPYFTEhtnFQGRVFMTHPTKAIYKLLLTDFVKVSDVHVddqlfteqn 154
                    589999998754333223....333566789***********************755444334444445555555555544433333555444444 PP

                    ...TTEEEEEE-TTSEEEECSTTEEEEEEEE-EE--CTCCE-TTTSEEEEEECTTEEEEEESS-S---HH..HHHHHCT..-SEEEEE-S CS
  Lactamase_B_2  83 ...pavnvheldwgesfelgdggleitatparhksgrrldrnagdtlGlriegggkrvyyigDtgyipee..igerlgg..adlllldit 165
                          +++ +d ++++e +  g+++ +  a h  g          + +++e +g rv+y+gD  + p++  +g++     +d+l+++ t
     EFC39387.1 155 lldSLKKIELIDYHQELEHN--GIKFWCYNAGHVLGA---------AMFMVEIAGVRVLYTGDFSRQPDRhlLGAETPTmsPDVLIVEST 233
                    44445556666666666666..778888888887777.........99999999**********99995533333333244777777766 PP

>> Lactamase_B_3  Beta-lactamase superfamily domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5   0.2   1.5e-07   0.00034       6     133 ..      51     229 ..      49     236 .. 0.71

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 1.5e-07
  Lactamase_B_3   6 ghnsflletagarilvDPf..........kanlgyeppaeeaDlvlisqaledHahletlkql................................. 58 
                    g +++ll+ +g+++l D +                ++++ e+Dlvl+++ + dH+ + +                                     
     EFC39387.1  51 GRSAVLLQFKGKTVLFDCGihpaftgmasL-PFFDTIEPSEIDLVLVTHFHLDHCGALPYFTEhtnfqgrvfmthptkaiykllltdfvkvsdvhv 145
                    8899*************9877777665431.22345566****************87655444578888888888888888888888888888888 PP

  Lactamase_B_3  59 .............aenvkvleegeslevggleiravatshdavggsergenngflleqdgltiyhlGhlahelsseel...kelgrvDvvl 133
                                  +++++++  ++le +g++++  ++ h      + g   +f++e +g+++++ G+ + +++   l        +Dv++
     EFC39387.1 146 ddqlfteqnlldsLKKIELIDYHQELEHNGIKFWCYNAGH------VLG-AAMFMVEIAGVRVLYTGDFSRQPDRHLLgaeTPTMSPDVLI 229
                    8888555555555445555555566666666666555555......555.69****************99976665553223334566666 PP

>> Beta_lactamase3  Putative beta-lactamase-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.0       3.3   7.3e+03     136     170 ..      30      64 ..      28      66 .. 0.83
   2 !   14.7   0.0   5.8e-06     0.013     118     180 ..     149     210 ..     124     239 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 3.3
  Beta_lactamase3 136 yneliyfddltieakaagtflGWvnyllevekkki 170
                      + + iy ++l +++  ag  +G +  ll+++ k++
       EFC39387.1  30 HTQYIYGEKLVVTPLGAGNEVGRSAVLLQFKGKTV 64 
                      67889999999999999999999999888888774 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 5.8e-06
  Beta_lactamase3 118 iveeidierlkrnvkfiryneliyfddltieakaagtflGWvnyllevekkkilayisslslk 180
                         e ++ +  +++ +i y++ ++ + ++  +  ag  lG  ++++e+   + + y+  +s +
       EFC39387.1 149 LFTEQNLLDSLKKIELIDYHQELEHNGIKFWCYNAGHVLGAAMFMVEIAGVR-VLYTGDFSRQ 210
                      4556677777899***********************************9999.8888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (749 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       616  (0.0343577); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.73u 0.36s 00:00:01.08 Elapsed: 00:00:00.53
# Mc/sec: 4278.73
//
Query:       EFC39388.1  [L=985]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-37  129.8  14.8    5.7e-37  127.5  14.8    2.2  1  DUF229           Protein of unknown function (DUF229)
  ------ inclusion threshold ------
      0.018   15.3   2.1       0.13   12.6   0.0    2.9  2  Sigma_reg_N      Sigma factor regulator N-terminal
       0.05   12.7   4.3       0.11   11.6   4.3    1.5  1  ABC2_membrane_3  ABC-2 family transporter protein
      0.051   13.9   0.1      0.051   13.9   0.1    2.6  3  Orf78            Orf78 (ac78)


Domain annotation for each model (and alignments):
>> DUF229  Protein of unknown function (DUF229)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  127.5  14.8   1.3e-40   5.7e-37      36     496 ..     380     893 ..     351     894 .. 0.76

  Alignments for each domain:
  == domain 1  score: 127.5 bits;  conditional E-value: 1.3e-40
      DUF229  36 krln.erlenlkCeyreitrkrdkenlvgksklfkg.kklersvevkvnaeileteCaekgkkivqkdvfnfledrilpkkkkesstekekkkysVlil 132
                 ++ + ++   +kC+  ++++k+++  +v+     ++ kk+ +++  k   +  et    k+++++  + +++++   + +      + +  +  ++l +
  EFC39388.1 380 QI-KdTEIIVAKCSKGSDKAKKTSRDIVTRVAFNPElKKAAEETYTKRVKKLEETDKTLKDQSKK--PKHEYHQFAANIE-----YEYEMMHPVNILNI 470
                 23.22566677788877777777777777777777755555555555555555554444444444..6666666544333.....333367889***** PP

      DUF229 133 glDSlSrmnfaRslprtveflkk...............lghielqgynkVgdnsfpNlvalLtGk.......................ifdekeleadw 193
                  lD +Sr+nf+R+lprtv++l++               + ++++  yn Vg  s++N+ al  G                          ++k l+++ 
  EFC39388.1 471 ILDGTSRSNFIRELPRTVNVLEEieldqkrtmfkkpskHRVFQFFRYNTVGHSSRENIFALENGLkispafmknyfeetsgnfekdepARQQKLLTETL 569
                 ********************97522222222222221134577888******************99***************998888756666666667 PP

      DUF229 194 td.tekkvslDklnfiWkeFkkkGYeTlfaEDi.akiglfnyn........kkGFrk.qPtDhylRplllavekelkyvtreklnClgsredhnvlldy 281
                    +e + s+  ++ iW+  k+ GY T+f     + i +  +n        +  F+    +Dh l  l la ek+l +  +++ +Clgs+ + ++++dy
  EFC39388.1 570 IGaKEGDSSKLITHNIWNIAKQLGYVTMFTSSEcPYIKVKDPNkkklmdtsSHLFNAwHRADHNL--LSLACEKHLFK-SSNNRKCLGSKDLFEHMFDY 665
                 766777777778899**************854336666666662222222255555434589988..66788899887.456677************** PP

      DUF229 282 lrqflerysnsrlfgffwsnslsh.dkfnllealDedllkylkklekkgllentlvlllsDHGlrfgklrktsqGilEerlPlmlirlPpwlretypqa 379
                 +  f  +y +  +f+ ++ ++ +h ++  l++alD +l++++ ++ k+     tl++l s  G   g++  t  G+ E +lPl+ +++P++l+ ++  +
  EFC39388.1 666 TTDFFAKYPGTARFATIHFEESKHiRSRTLMNALDISLARFIVDITKE--HPHTLIVLSSGNGISHGPFYVTDVGQKEHQLPLLNLVVPEHLQLRHKDI 762
                 ************99998888888847788999****************..99*********************************************** PP

      DUF229 380 venlelnknkLttpfDvhatLkdilklaele..dkelqdnnkasee..........ergiSLfdpipknrtCadagIpehwCtCeekkkvttndt.... 462
                 + nl  n+++L+tpfD+ a+L + + + + e     + +++ ++e+            + S+++pi + r C++ag+ + wC C++++++  n +    
  EFC39388.1 763 FTNLARNQQQLVTPFDLYASLAHFMLFPQVElpAHYSLIHHVSTEQeekeekdeyeALAKSILQPIHNPRFCKHAGVDPRWCSCNKYETLDFNTQpysa 861
                 ***********************875433221122222222222222444555566899*******************************999988999 PP

      DUF229 463 lvnraaesvverineklktanlrklCeqlelqkv 496
                 +v+++ +s+v+ +n+ +k+  +++ C ++e ++v
  EFC39388.1 862 IVSTIVKSAVSYVNKIVKP--HKETCLPIESKSV 893
                 99*****************..5****99998876 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.7      0.15   6.9e+02      36      70 ..      53      90 ..      35      94 .. 0.80
   2 ?   12.6   0.0   2.9e-05      0.13       7      45 ..      99     138 ..      96     149 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.15
  Sigma_reg_N 36 yl...aekegnklrevlelaveitsPNvyvdsgsvsqs 70
                 y    +e+  +++ +++++a++ ++P ++  s++++++
   EFC39388.1 53 YSadsLEEGRHEFSNNINSASSTSNPTTTTSSKNYTYT 90
                 4344566778999**************99999888775 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 2.9e-05
  Sigma_reg_N   7 akrksilrivlislivlllifvilvvtllyl.aekegnkl 45 
                   ++k +l ++li l+++++ fv+ ++ +++l ++++g kl
   EFC39388.1  99 QQQKRFLVNILICLAIVIVTFVLGYLVYSKLfNSNNGAKL 138
                  689*********************7666666588888776 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   4.3   2.4e-05      0.11      95     183 ..      39     124 ..      17     136 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.4e-05
  ABC2_membrane_3  95 kgesatvtvlinssnlnss.....kailnalnsllqqlnasalvlqseatstsaninvestqleeelsnvasflvgliliilifitasfiavsi 183
                      ++ +++  +++nss++ +s     +++ n++ns ++++n        ++t +s+n+++++  l++ +++ ++flv +++ ++i i+ ++ + ++
       EFC39388.1  39 TTPNSSSPIVFNSSYSADSleegrHEFSNNINSASSTSN-------PTTTTSSKNYTYTNPKLPKNQQQQKRFLVNILICLAIVIVTFV-LGYL 124
                      578899999******999999999999999999888877.......4689999********999999999**99999888877766664.4344 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.1   1.1e-05     0.051      26      89 ..      69     127 ..      59     139 .. 0.56
   2 ?   -2.6   1.9       1.5   6.9e+03      37      37 ..     175     175 ..     144     212 .. 0.50
   3 ?   -3.1   0.1       2.2   9.7e+03      38      43 ..     437     442 ..     409     471 .. 0.46

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.1e-05
       Orf78  26 ldnddndkaenkkekksaaeknditekesnaaekaqalnillisllavvcvlvllyviyYfvil 89 
                 +++ +++++ +++++++++++++ +       +++q+++ +l+ +l +++++++ +v+ Y v +
  EFC39388.1  69 INSASSTSNPTTTTSSKNYTYTNPKL-----PKNQQQQKRFLVNILICLAIVIVTFVLGYLVYS 127
                 22333333333333333333333333.....344445566777777778888888888877755 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 1.5
       Orf78  37 k 37 
                 +
  EFC39388.1 175 T 175
                 1 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.2
       Orf78  38 kekksa 43 
                  +++s+
  EFC39388.1 437 LKDQSK 442
                 111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (985 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1698  (0.0947069); expected 358.6 (0.02)
Passed bias filter:                      688  (0.0383736); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.87u 0.34s 00:00:01.21 Elapsed: 00:00:00.52
# Mc/sec: 5707.03
//
Query:       EFC39389.1  [L=611]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-07   31.5   0.1    3.3e-06   27.1   0.1    2.7  2  SH2       SH2 domain
     0.0045   17.7   1.5      0.033   14.9   0.3    2.7  2  Cbl_N2    CBL proto-oncogene N-terminus, EF hand-like domain


Domain annotation for each model (and alignments):
>> SH2  SH2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.1   0.1   3.7e-10   3.3e-06       2      57 ..     295     365 ..     294     373 .. 0.88
   2 !    4.8   0.1    0.0033        30      13      61 ..     345     395 ..     341     404 .. 0.79

  Alignments for each domain:
  == domain 1  score: 27.1 bits;  conditional E-value: 3.7e-10
                 EESSSHHHHHHHHHHTTSSTTEEEEEEESSSTTEEEEEEEETT................EEEEEEEEEETTS CS
         SH2   2 yhgkisrkeaerlLleekkdGtFLvReSeskpGdytlsvvedg................kvkhykiqsteng 57 
                 ++g++s  ea++lL   +++Gt++ R+ e++pG++ +svvedg                k  hy ++++ ++
  EFC39389.1 295 FWGSMSSIEAQNLLDG-QEPGTYITRFAENEPGSFYVSVVEDGgdtfgyfdsllmnsnrKTYHYLVRRKRDE 365
                 89************99.**************************99999999999998888888888887776 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0033
                 HHHHT.TSSTTEEEEEEESS.STTEEEEEEEETT.EEEEEEEEEETTSEEEE CS
         SH2  13 rlLle.ekkdGtFLvReSes.kpGdytlsvvedg.kvkhykiqstengkyyi 61 
                 +lL++ ++k+ ++LvR  +   +G++ + +++++ + kh ki+++ ++ y +
  EFC39389.1 345 SLLMNsNRKTYHYLVRRKRDeREGKMYFVLIDSDmDYKHEKIENLFKQ-YHL 395
                 567776889999***876554999999999999999999999998775.554 PP

>> Cbl_N2  CBL proto-oncogene N-terminus, EF hand-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.13   1.1e+03      17      49 ..     124     156 ..     116     168 .. 0.83
   2 !   14.9   0.3   3.7e-06     0.033      43      75 ..     248     280 ..     229     284 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.13
                 TT-SEEEHHHHHHHHHHHH---GGG.HHHHHHH CS
      Cbl_N2  17 gkktivpwkefkealekvhkvesskealaLkst 49 
                 ++++i + ++ k++le++  +++ + +++Lk  
  EFC39389.1 124 TENIINHLQQTKKNLEDLVAISEANARRSLKRS 156
                 56788899999***********99999999975 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 3.7e-06
                 HHHHHHHH-TT-SSEEEHHHHHHHHHHH--GGG CS
      Cbl_N2  43 alaLkstidltcndyisvfefdvFtrlFqPwss 75 
                 a+  k+ id tc++ +s+ +f + +++F P+s+
  EFC39389.1 248 AEFWKNNIDPTCDNVVSMIDFKTTLKWFGPFST 280
                 5556899************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (611 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2512  (0.140108); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.85u 0.31s 00:00:01.15 Elapsed: 00:00:00.49
# Mc/sec: 3728.75
//
Query:       EFC39390.1  [L=247]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-63  213.2   0.2    2.4e-63  212.9   0.2    1.1  1  Rer1      Rer1 family
  ------ inclusion threshold ------
        0.2   10.9   2.7       0.27   10.5   0.0    2.0  2  DUF1538   Protein of unknown function (DUF1538)


Domain annotation for each model (and alignments):
>> Rer1  Rer1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  212.9   0.2   2.7e-67   2.4e-63       9     171 .]       2     184 ..       1     184 [. 0.93

  Alignments for each domain:
  == domain 1  score: 212.9 bits;  conditional E-value: 2.7e-67
        Rer1   9 kyqklldkltpytleRWiatlvllllfllriillqgfyivaYalgiylLnlllafltPkfdpsleeeaaeeeaeega...elpt............... 89 
                 kyq++ld+l   ++ RW ++ +l++lfl+r+i+ +g+yi++Y lgiy++nl++af++Pkf p+ +++++ee++e++    +lp+               
  EFC39390.1   2 KYQSFLDRLNGKKTLRWSVLGFLFFLFLFRVIYFHGWYIICYGLGIYVINLFIAFISPKFRPEEDDDEDEEDEEANLgsaTLPStsvgrnfasgglfgq 100
                 79************************************************************9888766666665555666776888888888999998 PP

        Rer1  90 ..kkdeefrPfirrlpEfkfWlsatkailialvltffevfdvpVfwpiLlvyfivlfvltmrrqikhmikykyvpfdlgKkkyk 171
                   ++ ++ +Pf+rrlpEfkfW+s+tk ++i+l+l+ ++++d+pV+wpiLl y+i+l+++t+r+qi+hmik++y+pf++gKk+y+
  EFC39390.1 101 pkQDADDVKPFVRRLPEFKFWYSLTKGVVISLLLSSTRILDIPVYWPILLGYWIILLAVTLRKQIRHMIKHRYLPFTTGKKSYS 184
                 888999****************************************************************************95 PP

>> DUF1538  Protein of unknown function (DUF1538)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   1.0     0.059   5.3e+02     112     147 ..      22      59 ..      12      62 .. 0.64
   2 ?   10.5   0.0     3e-05      0.27     102     147 ..     119     163 ..     103     171 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.059
     DUF1538 112 glaialgvlrill..gislkylllpgyllvllltllvp 147
                 g+   l ++r+++  g+ +  + l +y++ l++++++p
  EFC39390.1  22 GFLFFLFLFRVIYfhGWYIICYGLGIYVINLFIAFISP 59 
                 55555666666654466666666666777777777666 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 3e-05
     DUF1538 102 vlilavaiGvglaialgvlrillgislkylllpgyllvllltllvp 147
                  + +++  Gv ++++l+ +ril +i++++ +l+gy ++ll + l +
  EFC39390.1 119 KFWYSLTKGVVISLLLSSTRIL-DIPVYWPILLGYWIILLAVTLRK 163
                 56788999************86.89**********99988777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (247 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       701  (0.0390987); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.36s 00:00:00.97 Elapsed: 00:00:00.56
# Mc/sec: 1328.69
//
Query:       EFC39391.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.7e-19   70.2   0.2    2.3e-19   69.8   0.2    1.2  1  Pkinase      Protein kinase domain
    3.7e-11   42.8   0.2    4.7e-11   42.5   0.2    1.1  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.8   0.2   2.6e-23   2.3e-19       1     114 [.     153     282 ..     153     283 .] 0.92

  Alignments for each domain:
  == domain 1  score: 69.8 bits;  conditional E-value: 2.6e-23
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.......HHHHHHHHHHHHHSCTTB--EEEEEEE..SSEEEEEEE--TTEBHHHHHH CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.......kkvlrEikilkklkhpnivrlyevfee..kdelylvleyveggeladlle 90 
                 y+++++lG+Gs+GkV  ++ ++++k +A+K+++k   k  k+        +v+rEi+i+kkl+h+n+vrl+ev+ +  +d lyl+ ey+e+g + ++ e
  EFC39391.1 153 YTVISTLGKGSYGKVKLVL-DNNNKPFAMKIMNKAMLKRVKKagggnllMDVQREIAIMKKLSHQNVVRLFEVIDDrnSDFLYLLIEYAENGAILSMSE 250
                 78899*************9.699************9999999999*9999************************9987899***********9888887 PP

                 ........HHSS--HHHHHHHHHHHHHHHHHH CS
     Pkinase  91 ........rkgslseeeakkiakqilegleyl 114
                         +  ++  +++++++kq +eg++yl
  EFC39391.1 251 tntgeevpKPCKFRLNQIRSYLKQAIEGVQYL 282
                 7778777666778889***************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.5   0.2   5.3e-15   4.7e-11       3     120 ..     155     283 .]     153     283 .] 0.86

  Alignments for each domain:
  == domain 1  score: 42.5 bits;  conditional E-value: 5.3e-15
                  EEEEEEEESSEEEEEEEEET...TTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHT CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkg...ekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct..keepllivteyvkgGdLlkfLrkk 95 
                  + ++lG+G++GkV     ++      k   k ++K +k+    +   ++ +e++imkkl+h+n+v+l  v+   +++ l++++ey+++G +l++ +++
   EFC39391.1 155 VISTLGKGSYGKVKLVLDNNnkpFAMKIMNKAMLKRVKKAGGGNLLMDVQREIAIMKKLSHQNVVRLFEVIDdrNSDFLYLLIEYAENGAILSMSETN 252
                  5689*********99887755444555666777888888888888999************************545555***************99999 PP

                  ......CTTTSBHHHHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr  96 ......ekekltlkdllsfalqvAkGmeyLe 120
                        +  k++l+++ s+  q  +G++yL+
   EFC39391.1 253 tgeevpKPCKFRLNQIRSYLKQAIEGVQYLQ 283
                  99999888999******************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       572  (0.0319036); expected 358.6 (0.02)
Passed bias filter:                      334  (0.018629); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.37s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 1568.72
//
Query:       EFC39392.1  [L=274]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.7e-55  186.3  25.6    7.8e-55  186.1  25.6    1.0  1  ELO       GNS1/SUR4 family
  ------ inclusion threshold ------
       0.06   13.2   0.1       0.11   12.3   0.1    1.4  1  Lig_chan  Ligand-gated ion channel


Domain annotation for each model (and alignments):
>> ELO  GNS1/SUR4 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  186.1  25.6   8.7e-59   7.8e-55       3     248 ..      31     272 ..      29     274 .] 0.87

  Alignments for each domain:
  == domain 1  score: 186.1 bits;  conditional E-value: 8.7e-59
         ELO   3 lsspkvpiliallYlllvllgpklmk.....nrkpfklkalvilhnlflavlSavgfvgmv.k.allevlkkkglvdllckddssdegrlrngllaflv 94 
                 ls++++p+  +++Y ++++l++ +++     +++ f+lk++  lhnlfl++lS++++ g + +   + +++ ++l +++c    + +++++ g+l f++
  EFC39392.1  31 LSHWRYPFFSLIAYTIFIYLFQFIINlkyrkEERVFELKRFTYLHNLFLCILSLFMATGNLlEsIRIYIRNGYSLESVFC----DPQTSTTVGPLNFWT 125
                 789***************666666665442233578***********************9953222333333899999**....788999********* PP

         ELO  95 llfylsKfvEllDTvflvlrkkqvsfLhvYHHatvmllmwaglrfatssgivfivllNsfvHaimYtYYflsalgakklvvpwkrliTslQilQfvvgl 193
                 ++fylsK +El+DTv+++l++++++fLhvYHH++++ l++++l  ++s ++ ++v+ N  +H+imY+YY  +a+g++   v wk+++T lQi Qfv+ l
  EFC39392.1 126 YIFYLSKHYELIDTVLMILKRRPLTFLHVYHHIVTLGLVYVALCDKMSLQW-VAVVTNGYIHVIMYYYYSRAAIGIN---VTWKKYVTILQIGQFVLDL 220
                 **********************************************66555.555*****************99997...69***************** PP

         ELO 194 .laavyllvsytlkkvgCdtsqtpkaairlnllyllslllLFlnffiksylkkkkk 248
                  +  +yl++ y+++ v+C+ s   +++++l+  ++ls+llLFl+f++++y  ++kk
  EFC39392.1 221 vVPQLYLYYLYVAE-VKCSGS---EEVLWLGQGVILSFLLLFLQFYVHTYRVERKK 272
                 88888888887777.9**777...99************************887776 PP

>> Lig_chan  Ligand-gated ion channel
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   1.3e-05      0.11       3      62 ..      32      90 ..      30     100 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 1.3e-05
                XXXXXXXTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHHH.HHHHHHHHHHHHHHHHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxx RF
    Lig_chan  3 evWlsvlvalilvsivlflverfspyewrepeeaaetveneft.lsnslwfslgalvqqGc 62
                + W + +++li  +i+++l++ + + ++r++e+    + ++ft l+n +  +l+ ++  G 
  EFC39392.1 32 SHWRYPFFSLIAYTIFIYLFQFIINLKYRKEERV-F-ELKRFTyLHNLFLCILSLFMATGN 90
                569999************************9554.3.345555166777888999999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       588  (0.032796); expected 358.6 (0.02)
Passed bias filter:                      217  (0.0121033); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.51
# Mc/sec: 1614.21
//
Query:       EFC39393.1  [L=420]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.036   14.4   0.1       0.12   12.7   0.1    1.9  1  zf-Di19      Drought induced 19 protein (Di19), zinc-binding
        7.8    7.2   5.9        2.6    8.7   0.5    2.7  2  ABC_trans_N  ABC-transporter N-terminal
        9.3    6.4  10.0        2.4    8.3   0.8    3.2  3  DUF3560      Domain of unknown function (DUF3560)


Domain annotation for each model (and alignments):
>> zf-Di19  Drought induced 19 protein (Di19), zinc-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1     2e-05      0.12      25      50 ..      43      71 ..      30      76 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2e-05
     zf-Di19 25 HrveskevvCPvCaekvtk...dlvaHlt 50
                 r+++++ vCP+C   v++   ++ +H++
  EFC39393.1 43 KRKTTTYRVCPMCDRAVGNfgtNFKNHFR 71
                578999*******9665533339999985 PP

>> ABC_trans_N  ABC-transporter N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.5   0.00043       2.6      20      56 ..     134     173 ..     109     175 .. 0.63
   2 ?   -0.1   0.7      0.25   1.5e+03      30      44 ..     371     395 ..     287     412 .. 0.57

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00043
  ABC_trans_N  20 e..sssedeeeedseFdlekwlknlreridrdg...ikprkl 56 
                  +  + ++ ++e+d   +l+k++k++ +++ ++     k +k+
   EFC39393.1 134 TvaDGEDVSDEDD--DNLKKFMKSIAKEQKKSSrsrSKKKKV 173
                  1444455555555..89***********99877655666665 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.25
  ABC_trans_N  30 d.........se.Fdlekwlknlre 44 
                            se  d +++l++++ 
   EFC39393.1 371 InsihcdtseSElKDKKRILSQILS 395
                  1333333444455555555555544 PP

>> DUF3560  Domain of unknown function (DUF3560)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.4       0.2   1.2e+03      91     114 ..      24      47 ..       5      51 .. 0.76
   2 ?    8.3   0.8   0.00041       2.4      85     123 ..     135     173 ..     113     174 .. 0.86
   3 ?    2.7   0.1     0.022   1.3e+02      92     122 ..     325     355 ..     299     357 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.2
     DUF3560  91 issddpdaierliekleaekrkqe 114
                 i +d  ++i r+i++ e++krk++
  EFC39393.1  24 IIKDSDQSIIRYINTAEKSKRKTT 47 
                 678888999999999999999876 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.00041
     DUF3560  85 aesnasissddpdaierliekleaekrkqermkaeneii 123
                 +++ +++s +d d ++++++ +++e++k++r++++++++
  EFC39393.1 135 VADGEDVSDEDDDNLKKFMKSIAKEQKKSSRSRSKKKKV 173
                 566677999***********************9999875 PP

  == domain 3  score: 2.7 bits;  conditional E-value: 0.022
     DUF3560  92 ssddpdaierliekleaekrkqermkaenei 122
                 + d+ +++erl+++le++++ +++  ++ e+
  EFC39393.1 325 EYDECEHVERLTKNLEKMIEHNSNELERDEK 355
                 56788999*********99999888877766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (420 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2570  (0.143343); expected 358.6 (0.02)
Passed bias filter:                      863  (0.0481343); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.33s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 2414.33
//
Query:       EFC39394.1  [L=191]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.4e-20   73.5   7.0    6.8e-12   45.7   0.2    2.2  2  EF-hand_7     EF-hand domain pair
    2.8e-17   60.9  14.0    1.2e-08   33.9   0.8    4.2  4  EF-hand_1     EF hand
    3.8e-16   57.6  13.4      1e-07   31.3   0.3    4.0  4  EF-hand_6     EF-hand domain
    3.4e-13   49.2   2.8    2.4e-10   40.1   0.1    3.9  5  EF-hand_8     EF-hand domain pair
    1.5e-08   33.8   8.9    1.3e-06   27.6   0.5    3.0  3  EF-hand_5     EF hand
     0.0077   16.5   0.3        1.1    9.6   0.0    2.3  2  HTH_57        ThcOx helix turn helix domain
  ------ inclusion threshold ------
      0.028   14.7   3.2        1.9    8.8   0.2    2.9  3  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
      0.053   14.4   0.3       0.88   10.5   0.1    2.5  2  EF-hand_11    EF-hand domain
      0.073   13.0   4.9        8.4    6.4   0.2    3.2  3  EF-hand_4     Cytoskeletal-regulatory complex EF hand
      0.081   12.8   2.0        9.9    6.0   0.1    3.0  3  Caleosin      Caleosin related protein
       0.18   12.0   2.6         14    5.9   0.0    3.0  4  Dockerin_1    Dockerin type I domain
       0.21   12.4   5.0         11    7.0   0.2    3.1  3  DUF3887       Protein of unknown function (DUF3887)


Domain annotation for each model (and alignments):
>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   2.1   2.3e-10   3.4e-07       4      69 ..      18      80 ..      15      82 .. 0.90
   2 !   45.7   0.2   4.5e-15   6.8e-12       2      70 ..     112     186 ..     111     187 .. 0.89

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 2.3e-10
   EF-hand_7  4 lkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkd.GvisfdEFlkl 69
                 + +F+++D+d dg ld+ +l+ +++k+    g++ ++  +e+ +l++++++++d   i+fd F++l
  EFC39394.1 18 YRNIFDMFDSDMDGLLDEHDLMLVFTKL----GRTTETNGKEISDLINDLNSSSDkNGITFDQFVEL 80
                5778****************99899998....99999899**********99999669******987 PP

  == domain 2  score: 45.7 bits;  conditional E-value: 4.5e-15
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkifqga.......gegsklsdeelellfkefDtdkdGvisfdEFlkly 70 
                 ++lkeaF+++D ++dg ++k+e+++++ k+ qg          ++++sd e+++lf  +Dt + G ++f+ F+ l+
  EFC39394.1 112 NDLKEAFNLFDENKDGEITKQEFRSMIYKL-QGLgnisesaPGNVSMSDAEIDYLFSIVDTANKGALNFEQFVSLF 186
                 79***********************88875.3445888888999999*************************9876 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.2   1.4     4e-07    0.0006       3      29 .]      19      45 ..      17      45 .. 0.93
   2 ?    1.3   0.0      0.21   3.2e+02      17      26 ..      72      81 ..      68      83 .. 0.86
   3 !   33.9   0.8   7.8e-12   1.2e-08       1      28 [.     113     140 ..     113     141 .. 0.94
   4 !   13.1   0.0   3.5e-05     0.052       1      28 [.     161     188 ..     161     189 .. 0.94

  Alignments for each domain:
  == domain 1  score: 19.2 bits;  conditional E-value: 4e-07
                HHHHHHHTTTSSSEEEHHHHHHHHHHH CS
   EF-hand_1  3 keiFrefDkDgdGkIdfeEfkellkkl 29
                ++iF++fD D dG +d  +++ +++kl
  EFC39394.1 19 RNIFDMFDSDMDGLLDEHDLMLVFTKL 45
                89********************99986 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.21
                EEHHHHHHHH CS
   EF-hand_1 17 IdfeEfkell 26
                I+f++f+el+
  EFC39394.1 72 ITFDQFVELI 81
                9*****9986 PP

  == domain 3  score: 33.9 bits;  conditional E-value: 7.8e-12
                 HHHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellkk 28 
                 +lke+F++fD ++dG I+++Ef++++ k
  EFC39394.1 113 DLKEAFNLFDENKDGEITKQEFRSMIYK 140
                 69***********************987 PP

  == domain 4  score: 13.1 bits;  conditional E-value: 3.5e-05
                 HHHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   1 elkeiFrefDkDgdGkIdfeEfkellkk 28 
                 e++ +F+++D+ + G ++fe+f++l++k
  EFC39394.1 161 EIDYLFSIVDTANKGALNFEQFVSLFTK 188
                 7999*********************987 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   1.1   9.3e-08   0.00014       3      31 .]      19      46 ..      17      47 .. 0.92
   2 ?    0.2   0.1      0.62   9.3e+02      12      26 ..      68      81 ..      62      88 .. 0.78
   3 !   31.3   0.3   6.8e-11     1e-07       1      27 [.     113     139 ..     113     145 .. 0.90
   4 !   10.7   0.1   0.00027      0.41       1      28 [.     161     188 ..     161     190 .. 0.92

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 9.3e-08
   EF-hand_6  3 reaFklfDkdgdGkidaeElrkalrkalg 31
                r +F++fD d dG +d ++l+ +++ +lg
  EFC39394.1 19 RNIFDMFDSDMDGLLDEHDLMLVFT-KLG 46
                889*********************9.676 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.62
   EF-hand_6 12 dgdGkidaeElrkal 26
                d++G i++++++ ++
  EFC39394.1 68 DKNG-ITFDQFVELI 81
                4454.9999998876 PP

  == domain 3  score: 31.3 bits;  conditional E-value: 6.8e-11
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalr 27 
                 +l+eaF+lfD ++dG+i+++E+r+++ 
  EFC39394.1 113 DLKEAFNLFDENKDGEITKQEFRSMIY 139
                 589********************9875 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00027
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalrk 28 
                 e++++F + D+ + G +++e+++++++k
  EFC39394.1 161 EIDYLFSIVDTANKGALNFEQFVSLFTK 188
                 6899*******************99984 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   2.3     0.014        21      27      49 ..      17      39 ..       6      45 .. 0.80
   2 ?    2.0   0.4      0.13   1.9e+02       2      37 ..      30      65 ..      30      81 .. 0.68
   3 ?   -1.2   0.0       1.2   1.9e+03       4      12 ..      71      79 ..      68      87 .. 0.68
   4 !   16.1   0.5     5e-06    0.0075      24      52 ..     110     138 ..     100     141 .. 0.86
   5 !   40.1   0.1   1.6e-13   2.4e-10       2      54 ..     126     188 ..     125     189 .. 0.93

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.014
   EF-hand_8 27 evdilfrefDtdgdGkisfeEFc 49
                  + +f+ fD d dG ++  + +
  EFC39394.1 17 TYRNIFDMFDSDMDGLLDEHDLM 39
                56789************998877 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.13
   EF-hand_8  2 kgkItreelrrilrilglkkglseeevdilfrefDt 37
                +g ++ ++l+   ++lg    ++ +e+ +l++ +  
  EFC39394.1 30 DGLLDEHDLMLVFTKLGRTTETNGKEISDLINDLNS 65
                688899999996677775557899999999886664 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 1.2
   EF-hand_8  4 kItreelrr 12
                 It++ +++
  EFC39394.1 71 GITFDQFVE 79
                578887776 PP

  == domain 4  score: 16.1 bits;  conditional E-value: 5e-06
   EF-hand_8  24 seeevdilfrefDtdgdGkisfeEFcvll 52 
                 +e+++ + f++fD+++dG i++ EF  + 
  EFC39394.1 110 TENDLKEAFNLFDENKDGEITKQEFRSMI 138
                 78889999*****************9875 PP

  == domain 5  score: 40.1 bits;  conditional E-value: 1.6e-13
   EF-hand_8   2 kgkItreelrril.rilglkk.........glseeevdilfrefDtdgdGkisfeEFcvller 54 
                 +g+It++e+r+++ ++ gl           ++s+ e+d lf+ +Dt ++G+++fe F+ l+++
  EFC39394.1 126 DGEITKQEFRSMIyKLQGLGNisesapgnvSMSDAEIDYLFSIVDTANKGALNFEQFVSLFTK 188
                 8**********9966668888**************************************9986 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.9   0.00026      0.39       4      22 ..      21      39 ..      19      42 .. 0.84
   2 !   27.6   0.5   8.7e-10   1.3e-06       1      24 [.     114     137 ..     114     138 .. 0.92
   3 ?   -2.8   0.0       3.7   5.5e+03       4      15 ..     165     176 ..     163     180 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00026
                HHHHH-SS-SSCE-HHHHH CS
   EF-hand_5  4 tFqaiDlNgDGkIskeELk 22
                 F+++D ++DG ++   L+
  EFC39394.1 21 IFDMFDSDMDGLLDEHDLM 39
                5***********9987775 PP

  == domain 2  score: 27.6 bits;  conditional E-value: 8.7e-10
                 HHHHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIskeELktl 24 
                 lk++F+ +D N+DG I+k+E++ +
  EFC39394.1 114 LKEAFNLFDENKDGEITKQEFRSM 137
                 6889*****************986 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 3.7
                 HHHHH-SS-SSC CS
   EF-hand_5   4 tFqaiDlNgDGk 15 
                 +F+ +D+ + G 
  EFC39394.1 165 LFSIVDTANKGA 176
                 688899855555 PP

>> HTH_57  ThcOx helix turn helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.022        32      50      78 ..      69      97 ..      48     101 .. 0.84
   2 !    9.6   0.0   0.00074       1.1      52      89 ..     108     149 ..     101     152 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.022
                HT-B-HHHHHHHHHHHH-HHHHHHHHHHH CS
      HTH_57 50 agnaTeekLselvlekdgvealekFeayL 78
                ++++T ++ +el+ e++++++++k  + L
  EFC39394.1 69 KNGITFDQFVELIGESEDESKGNKLLSFL 97
                5789****************999876655 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00074
                 -B-HHHHHHHH....HHHH-HHHHHHHHHHHHHHHHTT-EEE CS
      HTH_57  52 naTeekLselv....lekdgvealekFeayLqkLielGwlcy 89 
                   Te++L+e      ++kdg+ + ++F +++ kL  lG ++ 
  EFC39394.1 108 MHTENDLKEAFnlfdENKDGEITKQEFRSMIYKLQGLGNISE 149
                 556777776653233589********************9986 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.2     0.023        35      52      83 ..      14      45 ..       5      79 .. 0.82
   2 ?    8.8   0.2    0.0013       1.9      40      83 ..      97     141 ..      73     149 .. 0.64
   3 ?    0.4   0.0      0.53     8e+02      48      75 ..     154     181 ..     144     189 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.023
  SPARC_Ca_bdg 52 ckepvawkFsklDtnsdkvlsksELaplrapl 83
                  ++e+ +  F+ +D + d++l++++L  + ++l
    EFC39394.1 14 HRETYRNIFDMFDSDMDGLLDEHDLMLVFTKL 45
                  45555667999*************99887665 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.0013
  SPARC_Ca_bdg  40 lekkeeeknlke.ckepvawkFsklDtnsdkvlsksELaplrapl 83 
                   l++k+ +k   + +++ ++  F+ +D n+d+ ++k+E +++  +l
    EFC39394.1  97 LTSKKSKKVAGMhTENDLKEAFNLFDENKDGEITKQEFRSMIYKL 141
                   444444444433045667888888888888888888888876655 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.53
  SPARC_Ca_bdg  48 nlkeckepvawkFsklDtnsdkvlsksE 75 
                   n+++   ++ + Fs +Dt + + l+ + 
    EFC39394.1 154 NVSMSDAEIDYLFSIVDTANKGALNFEQ 181
                   6778888999999999999888887665 PP

>> EF-hand_11  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0        10   1.5e+04      36      46 ..      12      22 ..       6      36 .. 0.54
   2 ?   10.5   0.1   0.00059      0.88      22      83 ..     114     187 ..      96     191 .] 0.69

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 10
                EE-HHHHHHHH CS
  EF-hand_11 36 tvsreefraic 46
                   re +r i 
  EFC39394.1 12 NYHRETYRNIF 22
                44444444443 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00059
                 HHHHHHHH-TT-SSEE-HHHHHHHHHH.....HT--.........--HHHHHHHHHTS-B-TTS-EEHHHHHHHHC CS
  EF-hand_11  22 ivqefenfdtlksntvsreefraictr.....rvqi.........ltdeqfdrlwselpvnakgrlkyqdflskls 83 
                 + + f+ fd  k   ++++efr++  +     +  i         ++d ++d l+s +    kg l++++f+s ++
  EFC39394.1 114 LKEAFNLFDENKDGEITKQEFRSMIYKlqglgN--IsesapgnvsMSDAEIDYLFSIVDTANKGALNFEQFVSLFT 187
                 455689999999999*******98765221111..11222222236799999999999999999999999999876 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.2    0.0056       8.4      34      68 ..       7      41 ..       4      76 .. 0.81
   2 ?    2.0   0.1      0.13     2e+02      41      66 ..     110     135 ..      82     143 .. 0.81
   3 ?    5.4   0.0     0.012        17      37      66 ..     154     183 ..     144     188 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0056
   EF-hand_4 34 vlknskleedklekiwdladidedgkldfeefcia 68
                +lk+ + + +   +i+d+ d d dg ld ++++++
  EFC39394.1  7 MLKKENYHRETYRNIFDMFDSDMDGLLDEHDLMLV 41
                7888899999999**************98877655 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.13
   EF-hand_4  41 eedklekiwdladidedgkldfeefc 66 
                 +e+ l++ ++l d ++dg++  +ef 
  EFC39394.1 110 TENDLKEAFNLFDENKDGEITKQEFR 135
                 567899999**********9999995 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.012
   EF-hand_4  37 nskleedklekiwdladidedgkldfeefc 66 
                 n  +++ +++ ++++ d  + g l+fe+f+
  EFC39394.1 154 NVSMSDAEIDYLFSIVDTANKGALNFEQFV 183
                 56788999999******************8 PP

>> Caleosin  Caleosin related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.1     0.064        96      11      35 ..      23      47 ..      15      52 .. 0.86
   2 ?    6.0   0.1    0.0067       9.9       5      32 ..     113     140 ..     109     151 .. 0.73
   3 ?    0.5   0.0      0.33   4.9e+02      92     121 ..     159     188 ..     148     190 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.064
    Caleosin 11 aFfDrdkdGiiypldtyrgfralgf 35
                + fD+d dG++  +d +  f +lg 
  EFC39394.1 23 DMFDSDMDGLLDEHDLMLVFTKLGR 47
                5799999999999999999999985 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0067
    Caleosin   5 vLqqHvaFfDrdkdGiiypldtyrgfra 32 
                  L++ ++ fD++kdG i+ ++  + +++
  EFC39394.1 113 DLKEAFNLFDENKDGEITKQEFRSMIYK 140
                 5667778899999999998886555555 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.33
    Caleosin  92 pqkfeeifskyakekkdaltlkevlellkg 121
                  ++ + +fs  ++ +k+al+++++++l+++
  EFC39394.1 159 DAEIDYLFSIVDTANKGALNFEQFVSLFTK 188
                 56788999999********99999988765 PP

>> Dockerin_1  Dockerin type I domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1     0.064        95      35      56 ..      23      44 ..      15      46 .. 0.83
   2 ?    4.1   0.9     0.036        54       3      44 ..      26      64 ..      24      75 .. 0.75
   3 ?    5.9   0.0    0.0095        14      35      57 ..     119     141 ..      95     142 .. 0.82
   4 ?   -1.8   0.0       2.4   3.6e+03       8      15 ..     153     160 ..     150     163 .. 0.61

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.064
                GGGSTT-SSCESHHHHHHHHHH CS
  Dockerin_1 35 kaaDvNgDGrvnalDallviny 56
                +++D + DG  +  D++lv  +
  EFC39394.1 23 DMFDSDMDGLLDEHDLMLVFTK 44
                5789999999999999998655 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.036
                ETTSSSC-SHHHHHHHHHHCTSSEBTTSCCCHGGGSTT-SSC CS
  Dockerin_1  3 DVNgDgkVnalDalliinylnqregqssssngkaaDvNgDGr 44
                D + Dg  +  D++l+   l    +++ ++ ++  D+ +D +
  EFC39394.1 26 DSDMDGLLDEHDLMLVFTKLG---RTTETNGKEISDLINDLN 64
                778888888888888888888...666666666666666655 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0095
                 GGGSTT-SSCESHHHHHHHHHHH CS
  Dockerin_1  35 kaaDvNgDGrvnalDallvinyL 57 
                 + +D N+DG++++  +  +i +L
  EFC39394.1 119 NLFDENKDGEITKQEFRSMIYKL 141
                 66899*******99988887665 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 2.4
                 SC-SHHHH CS
  Dockerin_1   8 gkVnalDa 15 
                 g+V+  Da
  EFC39394.1 153 GNVSMSDA 160
                 55555555 PP

>> DUF3887  Protein of unknown function (DUF3887)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.2    0.0072        11       7      34 ..      12      39 ..      10      88 .. 0.81
   2 ?    5.8   0.3     0.017        25       4      47 ..     105     147 ..     102     159 .. 0.84
   3 ?   -0.1   0.0       1.2   1.8e+03       8      38 ..     157     187 ..     153     190 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0072
     DUF3887  7 llnsgdyeeaqdlfsedlkealseetle 34
                ++  + y +++d+f++d+   l+e +l+
  EFC39394.1 12 NYHRETYRNIFDMFDSDMDGLLDEHDLM 39
                777899************9999955544 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.017
     DUF3887   4 iiellnsgdyeeaqdlfsedlkealseetleeawkalkeelGef 47 
                 +  + +++d +ea++lf+e+   +++++++ ++   l + lG++
  EFC39394.1 105 VAGMHTENDLKEAFNLFDENKDGEITKQEFRSMIYKL-QGLGNI 147
                 66667899**********************9998877.667766 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 1.2
     DUF3887   8 lnsgdyeeaqdlfsedlkealseetleeawk 38 
                 +++++++ +++ ++   k al++e++ + ++
  EFC39394.1 157 MSDAEIDYLFSIVDTANKGALNFEQFVSLFT 187
                 5667778888888888889999988876655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (191 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       751  (0.0418874); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.58u 0.34s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1094.61
//
Query:       EFC39395.1  [L=417]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    9.8e-49  163.2   3.5    5.7e-17   61.4   0.1    3.9  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.9   0.1   8.1e-15   1.4e-10       6      82 ..      10     114 ..       5     125 .. 0.79
   2 !   58.7   0.2   2.3e-20   4.2e-16       5      92 ..     134     228 ..     130     232 .. 0.89
   3 !   61.4   0.1   3.2e-21   5.7e-17       8      94 ..     252     399 ..     248     402 .. 0.87

  Alignments for each domain:
  == domain 1  score: 40.9 bits;  conditional E-value: 8.1e-15
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH...............CCCSSTTTSCSS.......................HHHHHHHHHHHHHHHGGGT CS
   Mito_carr   6 lkellaGglagavatlvttPldvvKtrlqt...............qkksskksksaa.......................ildvlkkiykeeGlrglyr 66 
                 l+ ++ Gg+a ++++++ +P++++K+ lqt               +                                  i+  +k++ ++eG ++l+r
  EFC39395.1  10 LRIVMFGGIASSITKTLYAPIERLKIELQTcrhlrrqirnqaaasE----------IityaligsstvsmdvaklvrtkgIVGYMKHVAENEGWTSLFR 98 
                 566899************************7666665555444440..........055555666666666666667777******************* PP

                 THHHHHHHHHHHHHHH CS
   Mito_carr  67 Gllpnllrvapasalk 82 
                 G++ n++rv+p++ l 
  EFC39395.1  99 GNGLNITRVIPTRHLS 114
                 ***********98775 PP

  == domain 2  score: 58.7 bits;  conditional E-value: 2.3e-20
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS.......HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqtqkksskksksaa.......ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrl 92 
                 +l  + +++++g+  t++++Pld+v+trl + k  sk+  +++       + +++++++k+eG+ +l++G+++++++++p+  +  ++ye lk+ 
  EFC39395.1 134 FLIVFTSALMSGINLTVFAYPLDLVRTRLTVIKYYSKYHVKSSyfpyfgsAYRCVRELLKHEGMFALWKGMGASMVGIVPYVTCSITTYELLKKN 228
                 6677999************************88877765444478899999*****************************************985 PP

  == domain 3  score: 61.4 bits;  conditional E-value: 3.2e-21
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH................................................................CCCSSTT CS
   Mito_carr   8 ellaGglagavatlvttPldvvKtrlqt................................................................qkksskk 42 
                 +l  G ++  +++++ +P d+v+ r q+                                                                q      
  EFC39395.1 252 KLSYGTISSFLGKTLSYPADTVRRRRQLmgtmpsvidsavishsdihdrslpkpnlikleadefssgitrygstsiktegsastsaleplftQ------ 344
                 5778*******************************************************9999999999998887666665555555554433...... PP

                 TSCSS.......HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHHC CS
   Mito_carr  43 sksaa.......ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrlll 94 
                     +       +++++k+i++eeG+++l+rG+  n lrv+p +a+ fvlye lkr++ 
  EFC39395.1 345 ----KgqpmyknTMHAFKRIIQEEGMAALFRGWRLNALRVFPGHAIHFVLYEELKRMFG 399
                 ....05555555*********************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (417 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       515  (0.0287244); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2402.06
//
Query:       EFC39396.1  [L=334]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-06   28.7   1.8    4.5e-06   27.4   1.8    1.7  1  MRP-L46   39S mitochondrial ribosomal protein L46


Domain annotation for each model (and alignments):
>> MRP-L46  39S mitochondrial ribosomal protein L46
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.4   1.8   2.5e-10   4.5e-06       3     119 .]      79     196 ..      77     196 .. 0.65

  Alignments for each domain:
  == domain 1  score: 27.4 bits;  conditional E-value: 2.5e-10
                 EEEE-B--B--SB-----HHHHHH....HHHHHHHHHHT----HHHHTTHHHH..HHHHHHH---------.....----HHHHHHHHHHHHHHS.... CS
     MRP-L46   3 ikagliLsRpPvvtrelspfEkefYkYqkellerlelefskyfyfkkgtlael..kfkelkkklterdeevardigkpdlrqererndeqeikspks.. 97 
                 +k++ +L+R+P +  +++p+Eke+    +el++     + ++     +   e+  k+  +kk+  +++ +++ +   +++ +  e +d+q+++ +++  
  EFC39396.1  79 LKVAFCLERLPRLGNDMHPIEKEM----NELQKHNNNYYARHKWLDYTEYHEEwmKL--KKKQEGQKNAKKEGPDVHIKVPDPAEMTDKQKLEYERTqg 171
                 899*********************....88887777666555444333333331233..3444445555566667777777777777777777666533 PP

                 ....................----S-SSTT CS
     MRP-L46  98 ...yeealeeda.....rvikpasRvTeaD 119
                    + e           +  kp++R T++D
  EFC39396.1 172 kgyMTE-----GtdywiKNWKPQRRWTKDD 196
                 232222.....245777999*******998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (334 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1078  (0.0601261); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.51
# Mc/sec: 1963.79
//
Query:       EFC39397.1  [L=656]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0011   17.8   1.1     0.0011   17.8   1.1    2.2  2  Condensation  Condensation domain
     0.0013   17.4   0.2     0.0041   15.8   0.2    1.7  1  Transferase   Transferase family


Domain annotation for each model (and alignments):
>> Condensation  Condensation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   1.1   1.2e-07    0.0011      67     161 ..     180     276 ..     148     288 .. 0.71
   2 !    2.0   0.3    0.0074        66     344     442 ..     547     637 ..     517     646 .. 0.68

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.2e-07
                   TTEEEEEE-TT-----EEEE-T..TSSSHHHHHHHHHHHHHTC--SCCCS-.....SEEEEE..EESSTTEEEEEEEEECCT--TTTHHHHHHHHHH CS
  Condensation  67 ngepvQvileerevelevleisdleeseeeeaieefaqkdlqepfdLekgp.....Lfraal..fkiaenrlllllsvHHiivDGvSlgillrdlak 156
                    +  +Qv+l+e +++   +ei+  +e   ee ++ +++ ++ ++ d+ ++p      +r  +   k+++ ++++ +++ H + D+ S++i+l+++a+
    EFC39397.1 180 ITVDIQVLLDENSINPDNIEIE--NE---EELVKLLINHEIIHSWDILRDPnsvqaMWRLTItkSKHTDGKWVCCFTFFHALCDATSIKIFLEEFAS 271
                   5556788888888888888888..33...3456666666666666666554222223444441157999***************************9 PP

                   HHHHH CS
  Condensation 157 lYqql 161
                   l++ +
    EFC39397.1 272 LFDYM 276
                   98655 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.0074
                   S-SSSS-S-SEEEEESSS-HHCCCEEECCCCSEEECEE...E.....SSEEEEEEE..TTSSEEEEEEEETTTS-HHHHHHHHHHHHHHHHHHHHST CS
  Condensation 344 rkesrspLfdpvfsfenylgqeseeeesqlselklsvssveaeeeskydlslease..tngkltikieYntslFdeetierflerlkelleqviehp 438
                   +kes + +f+ +  +en+ gq++  e  + ++  ++++         + +s + ++  ++g+l ++i+Y +s+ + e ++r le +++ le +++h+
    EFC39397.1 547 KKESFQMVFSNIGKLENLTGQNVRFELISAAYSAIGNT---------NGISNIFYTnsRTGELIFSICYPESV-HYEHVQRYLENMMTCLELFANHT 633
                   55555555555666666666655555555555555511.........12222222224799**********97.56789****************99 PP

                   TSBC CS
  Condensation 439 eqkl 442
                    ++l
    EFC39397.1 634 LSPL 637
                   8875 PP

>> Transferase  Transferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.2   4.6e-07    0.0041     142     280 ..     242     454 ..     223     488 .. 0.65

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 4.6e-07
  Transferase 142 kcGgvalgvsvsHaiaDgaSlktfieswaelargekkvtvtplfarelllpr.........peppsvefdqlelrkfsasettevkevvtkkivle.k 229
                   +G  +   ++ Ha +D++S+k f+e++a+l      + + ++ ++el+  +                        +++s+++ ++  ++k+   + k
   EFC39397.1 242 TDGKWVCCFTFFHALCDATSIKIFLEEFASLFDYMYGEVQLVDVEKELMEVKrkalenihsL--------------LPPSPIQILEMLKSKTAPQKkK 325
                  466667777899*******************9999888888888888888883333322221..............4444444444444444433311 PP

  Transferase 230 lsaskleeLkkkasdesngk.............................................................................. 249
                   + s  e     + ++s++                                                                               
   EFC39397.1 326 NDQSPTETSS--STSSSTSStpthhhaesdipkklgklggllfysrfvsqvisynglspiisfplkspypepaqtkvlirhtskltltkliektktld 421
                  1111111111..11111111223444444444466777777777778888888888888888888888888888888888888888888888877777 PP

  Transferase 250 ..patrfesvtallWrcavkarkldesketvlg 280
                    ++  ++s++ l W +  ++ +++  ++t++g
   EFC39397.1 422 ltVTAIVQSIGCLAWVLSSRSYNEKAREKTTFG 454
                  653366788888888888888888877777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (656 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1433  (0.0799264); expected 358.6 (0.02)
Passed bias filter:                      797  (0.0444531); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.75u 0.36s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 3853.63
//
Query:       EFC39398.1  [L=558]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-10   41.4   0.5    2.6e-09   37.2   0.1    2.5  2  SPRY      SPRY domain
    5.1e-09   35.6   1.8     0.0029   18.0   0.0    2.7  2  Ank_3     Ankyrin repeat
    9.9e-07   29.3   0.1    1.8e-06   28.4   0.1    1.4  1  Ank_2     Ankyrin repeats (3 copies)
    4.2e-06   27.2   0.1      0.016   15.8   0.1    2.8  3  Ank_4     Ankyrin repeats (many copies)
    7.1e-06   26.2   0.2     0.0015   18.8   0.3    2.7  3  Ank_5     Ankyrin repeats (many copies)
    7.2e-06   26.2   2.5    0.00031   21.0   0.0    2.6  2  Ank       Ankyrin repeat


Domain annotation for each model (and alignments):
>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.2   0.1   8.7e-13   2.6e-09       2      93 ..     148     237 ..     147     245 .. 0.94
   2 ?    1.6   0.0     0.093   2.8e+02     100     119 ..     345     364 ..     331     365 .. 0.86

  Alignments for each domain:
  == domain 1  score: 37.2 bits;  conditional E-value: 8.7e-13
                 EEEEEEET.CCTSSEEEEEEEETTSSSSSTSSSTSSTTEEEEETETTEEEEETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTEEEEEEE CS
        SPRY   2 hyfevkiq.saeggsisvGlateqtdlsdksgegddrgswglcgdngtrtsaeqskaygkqparegdviGvalDleegelsFtkngknlgvaF 93 
                 +yfe+ +  s ++ si +G++ ++     + + g d+ s+++++d+g +++ +++ + +k +++ gd++G ++ l ++ ++Ft ng  lg  +
  EFC39398.1 148 CYFEISVIrSVKNVSIAIGFSSKDGY--YHAFPGFDDISYAYHSDTGAISHDSKQYEINK-SFQVGDTVGAGIILPQRHVFFTLNGVMLGKFY 237
                 8******99************99999..9999****************************.*************************9998665 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.093
                 SEEEEEEE.STCEEEEESSE CS
        SPRY 100 elfPvvslgngaslkinlgl 119
                  ++Pv+  ++ +++++n+g+
  EFC39398.1 345 VFYPVIGSNAPCTVTTNFGQ 364
                 69****************96 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.0   9.6e-07    0.0029       2      30 ..     440     472 ..     439     473 .. 0.86
   2 !   15.9   0.8   4.7e-06     0.014       5      31 .]     481     507 ..     480     507 .. 0.97

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 9.6e-07
       Ank_3   2 GetpLhlAarsgnl....e.ivkfLlenkgadvn 30 
                 G+++LhlA+  ++     + i+ +Lle kgadvn
  EFC39398.1 440 GQSLLHLACGLQSEpeitTqIINLLLE-KGADVN 472
                 9*************7654257******.9****9 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 4.7e-06
       Ank_3   5 pLhlAarsgnleivkfLlenkgadvna 31 
                 pLh+A++++n++ v  L  ++++d+n+
  EFC39398.1 481 PLHVACKNANITAVNILASHPNIDINI 507
                 9************************97 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.1   6.1e-10   1.8e-06       4      81 ..     412     507 ..     409     509 .. 0.71

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 6.1e-10
       Ank_2   4 AakngnlelvklLl..eg.adpn..k.ngktaLhyAakngnl.ei....vklLleh...ad...ndgrtpLhyAarsghleivklLlek.gadinl 81 
                 ++++ n e ++ +   eg +d+n  +  g++ Lh+A+  +++ ei    + lLle+   ++   ++   pLh+A+++ ++ +v++L  + ++din+
  EFC39398.1 412 CVQSLNIEKMESFFsnEGfTDVNrvSdRGQSLLHLACGLQSEpEIttqiINLLLEKgadVNlttRSLGAPLHVACKNANITAVNILASHpNIDINI 507
                 455422455555554333788888736***********875445443439****988663344566667********999*******777999986 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0012       3.5      25      43 ..     431     448 ..     407     453 .. 0.82
   2 !   15.8   0.1   5.2e-06     0.016      15      52 ..     459     495 ..     458     498 .. 0.90
   3 !    8.5   0.1     0.001         3       4      41 ..     481     517 ..     478     518 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0012
       Ank_4  25 adinaqdnrsGetalhiAa 43 
                  d+n++ +++G+++lh A+
  EFC39398.1 431 TDVNRV-SDRGQSLLHLAC 448
                 68****.888********9 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 5.2e-06
       Ank_4  15 elvrlLlekgadinaqdnrsGetalhiAakrgnveilk 52 
                 +++ lLlekgad+n +  rs   +lh A+k+ n+ ++ 
  EFC39398.1 459 QIINLLLEKGADVNLT-TRSLGAPLHVACKNANITAVN 495
                 5789************.999999**********99885 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.001
       Ank_4   4 aLhyaaisgrlelvrlLlek.gadinaqdnrsGetalhi 41 
                 +Lh a++  ++ +v +L ++ ++din        ta ++
  EFC39398.1 481 PLHVACKNANITAVNILASHpNIDINIL--HKKKTACDF 517
                 7*******************99***987..556666665 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       3.5     1e+04      40      53 ..     354     367 ..     353     369 .. 0.83
   2 ?    4.3   0.0     0.018        53       8      25 ..     432     449 ..     429     457 .. 0.90
   3 !   18.8   0.3     5e-07    0.0015       1      56 []     464     518 ..     459     518 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.5
       Ank_5  40 adlnltdsrGltal 53 
                 a +++t++ G+ ++
  EFC39398.1 354 APCTVTTNFGQIPF 367
                 7899******9987 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.018
       Ank_5   8 dvnrldgggntpLhvAak 25 
                 dvnr   +g++ Lh+A+ 
  EFC39398.1 432 DVNRVSDRGQSLLHLACG 449
                 7999************96 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 5e-07
       Ank_5   1 LlehgpadvnrldgggntpLhvAakygaadvvrlLl.argadlnltdsrGltaldlA 56 
                 Lle+g advn + +    pLhvA+k+ + + v++L   ++ d+n+  +  +ta+d+A
  EFC39398.1 464 LLEKG-ADVNLTTRSLGAPLHVACKNANITAVNILAsHPNIDINILHKK-KTACDFA 518
                 89999.78887777777***************************99999.9999988 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   1.1e-07   0.00031       2      31 ..     440     475 ..     439     476 .. 0.81
   2 ?    4.1   0.9     0.024        71       5      22 ..     481     497 ..     480     509 .. 0.61

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.1e-07
                 SBBHHHHHH..HHTT.....HHHHHHHH.TTTSTTCBT CS
         Ank   2 GnTPLHlAa..tngk.....kriiklLL.hGAnlnald 31 
                 G + LHlA+  +  +     ++ii lLL +GA++n+++
  EFC39398.1 440 GQSLLHLACglQ--SepeitTQIINLLLeKGADVNLTT 475
                 899******541..35667778******99*****987 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.024
                 HHHHHHHHTTHHHHH.HHH CS
         Ank   5 PLHlAatngkkriik.lLL 22 
                 PLH+A+  ++++i+  ++L
  EFC39398.1 481 PLHVAC--KNANITAvNIL 497
                 9****9..55456663355 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (558 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       692  (0.0385967); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 3414.58
//
Query:       EFC39399.1  [L=239]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-09   37.8   0.0    2.9e-09   37.1   0.0    1.3  1  Vma12            Endoplasmic reticulum-based factor for assem
     0.0054   15.4   0.0     0.0065   15.1   0.0    1.1  1  MFS_2            MFS/sugar transport protein
  ------ inclusion threshold ------
      0.048   13.7   1.9      0.066   13.3   1.9    1.1  1  Polysacc_synt_C  Polysaccharide biosynthesis C-terminal domai


Domain annotation for each model (and alignments):
>> Vma12  Endoplasmic reticulum-based factor for assembly of V-ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.1   0.0   4.8e-13   2.9e-09       1     131 [.      74     194 ..      74     199 .. 0.86

  Alignments for each domain:
  == domain 1  score: 37.1 bits;  conditional E-value: 4.8e-13
       Vma12   1 sLlrgskvyvppp.ppkpepspEykallarLraeqeereYkrlinsvdpsqksgktdspsssddeltaqelkevnrqlilvlNiliSvvavffavwial 98 
                 +L++gsk+ + ++ p   ++ p +++l+++L+++   +eY++++++v         d+         ++++++ + ql + l+++++++  f+ ++ ++
  EFC39399.1  74 KLVKGSKIRLTKQtPTITKKDPKWLKLTEQLKKKMADEEYSKMVKNVV----GRPRDE---------REAINSYKGQLGVGLDLVVTMATMFILFFTIS 159
                 59******9999867788999*************************55....222233.........3457999************************* PP

       Vma12  99 rsartp..slpvrvllslvvallVgvAEvvvyaky 131
                 +++++   +++ ++l++l++ ++ ++ + ++++  
  EFC39399.1 160 QYIFEGenKTQNQMLFGLFGLIVGLLIDAILVIVR 194
                 ***98788999***********9999999988765 PP

>> MFS_2  MFS/sugar transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   1.1e-06    0.0065     123     196 ..     119     197 ..     107     221 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 1.1e-06
       MFS_2 123 pvltkdydeRtsltsvrsflsvlggvlaailafllvlilgg.....lkserkgylifaliialLmllgviivvlgtker 196
                 +v ++ +deR+ ++s++ +l v+  +++++ ++ +++++ +     ++++ ++ ++f+l++ ++ ll   i+v++  e+
  EFC39399.1 119 NVVGRPRDEREAINSYKGQLGVGLDLVVTMATMFILFFTISqyifeGENKTQNQMLFGLFGLIVGLLIDAILVIVRGEK 197
                 578899*******************99999888887777667***9888888888888888887777655555554444 PP

>> Polysacc_synt_C  Polysaccharide biosynthesis C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   1.9   1.1e-05     0.066       5      51 ..     146     192 ..     144     202 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.1e-05
  Polysacc_synt_C   5 lalsiiflslstvlssiLqglgrqkialkalvigalvklilnlllip 51 
                      ++ +++f+ ++t++++i+ g ++++  +++ ++g++v l++  +l+ 
       EFC39399.1 146 VTMATMFILFFTISQYIFEGENKTQNQMLFGLFGLIVGLLIDAILVI 192
                      567899999***********************************994 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1478  (0.0824363); expected 358.6 (0.02)
Passed bias filter:                      749  (0.0417759); expected 358.6 (0.02)
Passed Vit filter:                        94  (0.0052429); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 1335.53
//
Query:       EFC39400.1  [L=245]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (245 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1329  (0.0741257); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1401.74
//
Query:       EFC39401.1  [L=782]
Description: NAD-dependent epimerase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      4e-48  164.5   0.5    3.7e-43  148.2   0.2    2.2  2  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase
    1.5e-42  145.7   0.1    1.1e-37  129.8   0.0    2.4  2  Epimerase        NAD dependent epimerase/dehydratase family
    2.5e-09   36.7   0.3    3.7e-05   23.0   0.1    3.3  3  Polysacc_synt_2  Polysaccharide biosynthesis protein
    2.8e-09   36.4   0.7    5.7e-07   28.8   0.5    2.4  2  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
    0.00012   21.3   0.0       0.04   13.1   0.0    2.4  2  NAD_binding_4    Male sterility protein
  ------ inclusion threshold ------
      0.017   14.2   0.0        5.7    5.9   0.0    2.5  2  RmlD_sub_bind    RmlD substrate binding domain
       0.02   14.7   0.0      0.043   13.6   0.0    1.5  1  DUF5315          Disordered region of unknown function (DUF53


Domain annotation for each model (and alignments):
>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   6.7e-06     0.017       1      27 [.     104     130 ..     104     162 .. 0.71
   2 !  148.2   0.2   1.4e-46   3.7e-43      35     331 ..     191     480 ..     169     481 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 6.7e-06
                    EEETTTSHHHHHHHHHHHHCT-CCEEE CS
  GDP_Man_Dehyd   1 LiTGiaGfiGsylaelLlekgyevhgi 27 
                    L+TG aGfiG +lae+L ++++  ++ 
     EFC39401.1 104 LVTGSAGFIGFHLAEKLAKEEFAYWNN 130
                    9******************98876653 PP

  == domain 2  score: 148.2 bits;  conditional E-value: 1.4e-46
                    TTHHHHHCTTT...TTGC..CEEEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHTTSHHHHHHHHTHHHHHHHHHHHHCT..TTSEEEEEE CS
  GDP_Man_Dehyd  35 ntgriehlakdpkeelee..nlklhkgDltDssslerllaevqpdevynLAAqshVdvsfekPeytaevnvlGtlrLLeairalglekkvrfyqaS 128
                     +++ +++ +++++++++  ++++++gD++++s l ++++++ ++ v++LAAq  V++s+++P++++++n+l  ++LLe   +++ ++   f  aS
     EFC39401.1 191 LIEQASTILRKEEADIKPfiDFQVIEGDVCNTSILSEIFEKYTFTHVLHLAAQAGVRYSLKNPQTYIRNNILCQIELLETSVKYQKTNPPVFAYAS 286
                    44555566666667777766899**************************************************************9********** PP

                    EGGGG-S-SS...SSB-TTS--.---SHHHHHHHHHHHHHHHHHHHH---EEEEEE-EEESTTS-TTSCCCHHHHHHHHHHTTS-C-EEC.TTTT- CS
  GDP_Man_Dehyd 129 tsEvYGkvqe...vpqtEttpf.yPrsPYaaaKlyadwivvnyreayglfavngilfnhesprrgetfvtrkitravarialgkqevlyl.Gnlda 219
                    +s vYG+ qe   + ++E+  + +P++ Y+a+K++++ +++ y+  yg++++  ++f  ++p+  +      +   v +i +gk  +ly     + 
     EFC39401.1 287 SSSVYGNIQEfdpSAFHEQMNInKPTNVYSASKISQELFAETYNYLYGIPVIGLRFFTVYGPYGRP---DMALFSWVDQIVKGKPITLYTlEGKEL 379
                    ********9743356999988736***************************************755...5779999********777765266666 PP

                    EEEEEEHHHHHHHHHHHHHCSS---EEE-TT-EEECHHCHHCCHHCCCHHHHHH............TTGGCCCEECGG--SS--SB--B-THHHHH CS
  GDP_Man_Dehyd 220 kRdwghvkDyveamwlmlqqdkpedyviatgethsvrefvelaflelgktiewegkgeeevgrakesgkvvvevdpkyfrpgevdlllgdaskake 315
                     Rd+++++D+v+++ + ++ +      +   e   v ++++l +    k        +++++ +++  +++ +++ ++  p++ + +++d++  +e
     EFC39401.1 380 MRDFTYIDDIVNGIINSMNYGDR----VKREEGRAVHDVFNLGNHTPEK-------VTDMIKYIEKALDKKAKINHVKKPPTDMTITFADITHSQE 464
                    9***************9999863....5667777777777765554433.......23456677788889999*********************** PP

                    HH----SS-HHHHHHH CS
  GDP_Man_Dehyd 316 eLgWkpkvsfeelvre 331
                     L+++pk+++e++vr+
     EFC39401.1 465 LLNFQPKTKLEDGVRK 480
                    **************97 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.6   0.0   1.3e-05     0.033       1      22 [.     103     124 ..     103     166 .. 0.82
   2 !  129.8   0.0   4.2e-41   1.1e-37      38     234 ..     201     405 ..     169     418 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.3e-05
                 EEEETTTSHHHHHHHHHHHHCT CS
   Epimerase   1 ilVtGatGfiGsalvkallekg 22 
                 +lVtG +GfiG +l+++l+++ 
  EFC39401.1 103 VLVTGSAGFIGFHLAEKLAKEE 124
                 79****************9987 PP

  == domain 2  score: 129.8 bits;  conditional E-value: 4.2e-41
                 HHCHHC......EEEE--TT-HHHHHHHHHHHT-SEEEE--S---HHHHHHSHHHHHHHHTHHHHHHHHHHHHH...TCTEEEEEEEGGGGTSCSS.SS CS
   Epimerase  38 arledl......elveldltdrsalerlfkeeqpdavihlAavggvaassedpadfieknlqgtlnlleaarka...gvkrllflsSsevYGkdae.qp 126
                 ++++d+      +++e+d+++ s l ++f+++ +++v+hlAa++gv+ s ++p+ +i++n+  + +lle + k+   ++  + ++sSs+vYG+ +e  p
  EFC39401.1 201 KEEADIkpfidfQVIEGDVCNTSILSEIFEKYTFTHVLHLAAQAGVRYSLKNPQTYIRNNILCQIELLETSVKYqktNPPVFAYASSSSVYGNIQEfDP 299
                 2333337778889***********************************************************88444555****************557 PP

                 ..BSTCSTTS--.--SSHHHHHHHHHHHHHHHHHHHHT-EEEEEEESEEESTTS-TTSTTSHHHHHHHHHHTTSSSEEEET..TST-EEEEEEHHHHHH CS
   Epimerase 127 ..keettltgpl.kpnspYaaaKlageklveayaaqyglnaiilrlfnlyGprngegevsrvipalirkilegkqevtllg..dgtalRdflyveDvae 220
                    +e++   ++ kp++ Y+a+K+  e  +e y+  yg+++i lr f++yGp+   g+++  ++ ++ +i +gk ++tl+     +  Rdf y++D+++
  EFC39401.1 300 saFHEQM---NInKPTNVYSASKISQELFAETYNYLYGIPVIGLRFFTVYGPY---GRPDMALFSWVDQIVKGK-PITLYTleGKELMRDFTYIDDIVN 391
                 7788888...999****************************************...9*****************.9999998566668*********** PP

                 HHHHHHHHHTT-ST CS
   Epimerase 221 aillvlehvdagdk 234
                 +i+  ++  d+ + 
  EFC39401.1 392 GIINSMNYGDRVKR 405
                 ***99998777554 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.017        44       1      22 [.     103     124 ..     103     158 .. 0.86
   2 !   23.0   0.1   1.4e-08   3.7e-05      33     119 ..     186     275 ..     173     281 .. 0.80
   3 !    6.8   0.0    0.0013       3.2     133     243 ..     310     432 ..     307     455 .. 0.74

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.017
                      EEEETTTSHHHHHHHHHHHHHB CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkkk 22 
                      vlvtG++G iG +l ++++k++
       EFC39401.1 103 VLVTGSAGFIGFHLAEKLAKEE 124
                      89***************99875 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 1.4e-08
                      HHHHHHHHHH.........-TTEEEE....E--TT-HHHHHHHTT..T-SEEEE------HHHHHHSHHHHHHHHHHHHHHHHHHHHHTT CS
  Polysacc_synt_2  33 Elklyeieke...leeelkkkklkveivpvigdvrdkerlekaleelkvdvvfhaAAlKhVPlveenpleaiktNvlgtenvieaaieag 119
                      E ++  ie+    l++e ++ k  +++ ++ gdv +++ l++++e+++   v+h AA   V    +np   i++N+l   +++e++++++
       EFC39401.1 186 EINQNLIEQAstiLRKEEADIKPFIDFQVIEGDVCNTSILSEIFEKYTFTHVLHLAAQAGVRYSLKNPQTYIRNNILCQIELLETSVKYQ 275
                      6666666666544333333333334445677************************************************99999998875 PP

  == domain 3  score: 6.8 bits;  conditional E-value: 0.0013
                      S--SHHHHHHHHHHHHHHHGGG--SSS--EEEEEEE-EETTGTTS...SHHHHHHHHHTTSSEEE...S-TT-EEEEE-HHHHHHHHHHHHHH- CS
  Polysacc_synt_2 133 nPtnvmGatKrlaekllqalakeseekktkfvvvRfGNVlgSrGS...viplFkkqikeggpvtv...TdpemtRyfmtieeavqLvlqalala 220
                      +Ptnv+ a+K  +e+++ +++         ++  Rf  V g  G     +  + +qi +g+p+t+     +e++R f  i++ v+ ++++++++
       EFC39401.1 310 KPTNVYSASKISQELFAETYNYLY---GIPVIGLRFFTVYGPYGRpdmALFSWVDQIVKGKPITLytlEGKELMRDFTYIDDIVNGIINSMNYG 400
                      7**************999999988...89999*********99963224556789********8731146899999999999999999998776 PP

                      -SS-.........EEEE--.-EEEHHHHHHHH CS
  Polysacc_synt_2 221 kgge.........ifvldmGepvkivdlakal 243
                      ++ +         +f l    p k++d+ k +
       EFC39401.1 401 DRVKreegravhdVFNLGNHTPEKVTDMIKYI 432
                      54333334455445555555666666666655 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.4   0.0    0.0031       7.9       1      21 [.     104     124 ..     104     144 .. 0.92
   2 !   28.8   0.5   2.2e-10   5.7e-07      48     270 ..     211     438 ..     172     445 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.0031
   3Beta_HSD   1 vvtGgaGFlGralvkeLvrle 21 
                 +vtG+aGF+G +l ++L ++e
  EFC39401.1 104 LVTGSAGFIGFHLAEKLAKEE 124
                 69*************998876 PP

  == domain 2  score: 28.8 bits;  conditional E-value: 2.2e-10
   3Beta_HSD  48 k..viegDvtdkdkleealegvd..vvihlaslvdvag.kltedeimkvnvkGTrnvleacvk...agvrvlvYtSsaevvgpnslgeeilngdEeley 138
                 +  viegDv++++ l+e  e+     v+hla+   v+    + +++ + n+    ++le+ vk   ++ +v+ Y Ss +v g+ ++ ++    +E++++
  EFC39401.1 211 DfqVIEGDVCNTSILSEIFEKYTftHVLHLAAQAGVRYsLKNPQTYIRNNILCQIELLETSVKyqkTNPPVFAYASSSSVYGNIQEFDPSA-FHEQMNI 308
                 14499**************98752269*****999987467789999*************99722145679*********99944444444.7888877 PP

   3Beta_HSD 139 eslhqdaypesKalaEklvlkaNgrtlknggrlyTcaLRpagiyGeg...dkllvpllkqlaklgla.lfkigdeevlsdrvYvgNvawahilAaralq 233
                  ++++++y+ sK   E +    N   l +   +  + LR  ++yG++   d  l+  + q++k + + l+ +  +e + d++Y + ++  +i  + + +
  EFC39401.1 309 -NKPTNVYSASKISQELFAETYNY--LYG---IPVIGLRFFTVYGPYgrpDMALFSWVDQIVKGKPItLYTLEGKELMRDFTYIDDIVNGIINSMNYGD 401
                 .4699******9776655555555..444...58899********9833345788889999998865167777788999*********99887666555 PP

   3Beta_HSD 234 dpkk.kssvagqayfisddsPvesyddfnltllkelgl 270
                   k+ + ++  +++   +++P +   d+   + k+l+ 
  EFC39401.1 402 RVKReEGRAVHDVFNLGNHTPEK-VTDMIKYIEKALDK 438
                 44443557788999999999999.77777777777775 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.0    0.0025       6.4       1      20 [.     105     124 ..     105     146 .. 0.89
   2 !   13.1   0.0   1.5e-05      0.04      63     208 ..     213     347 ..     174     399 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0025
                    EE-TTSHHHHHHHHHHHHHS CS
  NAD_binding_4   1 lTGaTGFLGkvLlekLLrtt 20 
                    +TG+ GF+G +L ekL +++
     EFC39401.1 105 VTGSAGFIGFHLAEKLAKEE 124
                    7***************9875 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 1.5e-05
                    EEEE--TTSGGGG--HHHHHHHHHH--EEEE--SS-S.STTSSE...EHHHHHHHHHHHHHHHTSSS--...-EEEEEEGGGTTS-TTT--SSS-H CS
  NAD_binding_4  63 kvveGDlseprlGLseedlqelaeevdviihsaAtvnfdepyke...llrvNveGtrevlelakklkkl..kvllhvSTayvngeregeveekvye 153
                    +v+eGD+++    + +e +++   + ++++h aA+  + +++k+    +r N++   e+le + k +k+   v+ + S++ v+g+ + e++     
     EFC39401.1 213 QVIEGDVCNTS--ILSEIFEKY--TFTHVLHLAAQAGVRYSLKNpqtYIRNNILCQIELLETSVKYQKTnpPVFAYASSSSVYGNIQ-EFDP---- 299
                    67777777665..667777777..7899*******999999987666899*************9877764569******99999999.6644.... PP

                    ......HHH--EEEETTTCCCHHHHHHHHHHHHHHHHHHHH---EEEEEE-EEE- CS
  NAD_binding_4 154 egekeekldederaklkglpntYeqsKalaEklvrearrrsglpvvivRpsiitg 208
                               e+ + ++ +n Y+ sK   E   ++++   g+pv+ +R  +++g
     EFC39401.1 300 -------SAFHEQMNINKPTNVYSASKISQELFAETYNYLYGIPVIGLRFFTVYG 347
                    .......5556888899999**************999999999998888777776 PP

>> RmlD_sub_bind  RmlD substrate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0    0.0024       6.1       2      29 ..     102     129 ..     101     195 .. 0.83
   2 ?    5.9   0.0    0.0022       5.7      34     156 ..     216     350 ..     185     357 .. 0.73

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0024
                    EEEEESTTSHHHHHHHHHCTTTSEEEEE CS
  RmlD_sub_bind   2 kilvtGanGqlGseLakqlaeeglevla 29 
                    k+lvtG+ G +G +La++la+e++++  
     EFC39401.1 102 KVLVTGSAGFIGFHLAEKLAKEEFAYWN 129
                    79*******************9987654 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0022
                    T--TTSHHHHHHHHHHH--SEEEE------HHHHHHSHHHHHHHHTHHHHHHHHHHHHCT-E....EEEEEEGGGS-S-...TTS-.B-TTS---- CS
  RmlD_sub_bind  34 eldltdaeavaellkeakpdvvvnaAAytavDkaEseeeaayavnaeavealAeaaaavgal....LihvStDyVFdGe...kkrp.YeeddetsP 121
                    e d+ + + + e++++     v ++AA   v    ++++   + n     +l e   +++ +    + + S+  V+       +++  e+ +  +P
     EFC39401.1 216 EGDVCNTSILSEIFEKYTFTHVLHLAAQAGVRYSLKNPQTYIRNNILCQIELLETSVKYQKTnppvFAYASSSSVYGNIqefDPSAfHEQMNINKP 311
                    67888888888899999999999999999999999999888888888888887777665542222378999999996656665556255567889* PP

                    SSHHHHHHHHHHHHHHHH-SSEEE....EEE-SEESSSS CS
  RmlD_sub_bind 122 lnvYGrtKlaGEqavlaagkkali....vRtswvygekg 156
                     nvY ++K+  E   + ++  + i    +R+  vyg +g
     EFC39401.1 312 TNVYSASKISQELFAETYNYLYGIpvigLRFFTVYGPYG 350
                    **********99988775443332223377777777776 PP

>> DUF5315  Disordered region of unknown function (DUF5315)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   1.7e-05     0.043      18      56 ..     144     181 ..     136     195 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.7e-05
     DUF5315  18 aeid.tLddVklsAeegkkthvFgeehekaLeelReaqik 56 
                 ++id +L+ V++s + g   + F++ ++  L+ +R++q++
  EFC39401.1 144 EQIDlALNNVERSVMIG--LDNFNDYYSTDLKYMRKKQLE 181
                 69***************..*******************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (782 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1106  (0.0616878); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.75u 0.37s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 4428.45
//
Query:       EFC39402.1  [L=669]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-55  188.8   2.0      2e-55  188.0   2.0    1.3  1  Pkinase          Protein kinase domain
    9.6e-47  159.4   0.8    1.6e-46  158.7   0.8    1.3  1  Pkinase_Tyr      Protein tyrosine kinase
    7.4e-05   21.7   0.9    0.00025   19.9   0.2    2.0  2  Pkinase_fungal   Fungal protein kinase
     0.0019   18.4   0.0     0.0049   17.1   0.0    1.7  1  Acetyltransf_1   Acetyltransferase (GNAT) family
     0.0035   16.7   0.1      0.018   14.4   0.0    2.0  2  Kinase-like      Kinase-like
     0.0035   16.4   0.1     0.0073   15.4   0.1    1.5  1  Seadorna_VP7     Seadornavirus VP7
  ------ inclusion threshold ------
      0.012   15.5   0.0      0.038   13.9   0.0    1.8  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
      0.014   15.8   0.0      0.039   14.4   0.0    1.8  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
       0.02   14.3   0.1      0.034   13.5   0.1    1.3  1  Kdo              Lipopolysaccharide kinase (Kdo/WaaP) family
       0.19   11.7   0.0       0.47   10.3   0.0    1.6  2  APH              Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  188.0   2.0   1.1e-58     2e-55       2     259 ..       5     261 ..       4     263 .. 0.89

  Alignments for each domain:
  == domain 1  score: 188.0 bits;  conditional E-value: 1.1e-58
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.......SSEEEEEEE--TTEBHHHHHH... CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.......kdelylvleyveggeladlle... 90 
                  +++ lG+Gs G+V+ a +k+t++++A+K+++ ++ ++ +    l+E + l++l+h+n+++++++f +       + +++l+ ey++gg+l++l++   
  EFC39402.1   5 YVIKILGRGSEGQVVLAEHKKTEEQIAIKRMEWSSLDEANI--HLNEAQKLRNLSHRNVIKYLGAFLHqyskkaeTLYVCLCIEYCPGGDLQKLITttc 101
                 57899*****************************9998765..8**********************99899987667788***************9999 PP

                 .HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHH CS
     Pkinase  91 .rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvily 188
                  ++++++e+++ ++a qi+egl+ylH+++iiHrDlKp+NiLid +g+lKi+DFG+++ l++ s +++++gt ++++ E+l+++ y++++D++s Gvil+
  EFC39402.1 102 kKERKMKEKDIVNYAIQIAEGLNYLHENNIIHRDLKPQNILIDASGVLKIGDFGISRVLDTLSMAKTQCGTIDFMSYEMLNKEFYDQSTDMYSFGVILL 200
                 88888********************************************************************************************** PP

                 HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 189 elltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                 +++++   +  + + +k            + ++e +         s+ + +l k ll+++p++R++a++ +
  EFC39402.1 201 QMMAEGKQMMVSMELQK----------NPNFFNEIEHYCVDTMGYSRGLFNLTKLLLSYQPRDRPSAAKTI 261
                 **987666662333332..........233333334444555667*********************98765 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.7   0.8   8.9e-50   1.6e-46       4     257 ..       7     262 ..       5     264 .. 0.90

  Alignments for each domain:
  == domain 1  score: 158.7 bits;  conditional E-value: 8.9e-50
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE...SSSS......EEEEEE--TTEBHHHHH CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct...keep......llivteyvkgGdLlkfL 92 
                   k lG+G+ G+Vv ++ k    k+e+++a+K ++ ++ +e  +  l+ea+ +++l+h+n++k+lg+ +   +  +      +++ +ey++gGdL+k +
   EFC39402.1   7 IKILGRGSEGQVVLAEHK----KTEEQIAIKRMEWSSLDE-ANIHLNEAQKLRNLSHRNVIKYLGAFLhqyS--KkaetlyVCLCIEYCPGGDLQKLI 97 
                  578************999....999********6655555.78889*********************96541..14567779999************* PP

                  HHT..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHH CS
  Pkinase_Tyr  93 rkk..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDv 188
                  +++  +++k++ kd++++a+q+A+G++yL++++++Hrdl  +N+L++ + v ki+DfG++r +   d+ ++++++   + +m+ E+l+++ + +++D+
   EFC39402.1  98 TTTckKERKMKEKDIVNYAIQIAEGLNYLHENNIIHRDLKPQNILIDASGVLKIGDFGISRVL---DTLSMAKTQCGTIDFMSYEMLNKEFYDQSTDM 192
                  9876578999999**************************************************...888888889999******************** PP

                  HHHHHHHHHHHTTSSGTTTTSHHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 189 WsfGvllwEiftlgespypglkneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRptfselve 257
                  +sfGv+l  ++  g++ + +++ ++  +++ + ++ +      ++ l +l k  ++++p++Rp+ ++ ++
   EFC39402.1 193 YSFGVILLQMMAEGKQMMVSMELQKNPNFFnEIEHYCVDTMGYSRGLFNLTKLLLSYQPRDRPSAAKTIK 262
                  *********************999999988444555777888999******************9887765 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.31   5.5e+02     252     311 ..      22      81 ..       8      85 .. 0.71
   2 !   19.9   0.2   1.4e-07   0.00025     316     405 ..     120     200 ..     104     203 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.31
  Pkinase_fungal 252 aevklkksesskkvekrsvdssv.stskrsrlenrvhrrlvispvGkpiekaespkellea 311
                     ++ k++++ + k++e +s d+ + + ++ ++l+  + +r vi+  G  +++++++ e l +
      EFC39402.1  22 EHKKTEEQIAIKRMEWSSLDEANiHLNEAQKLR-NLSHRNVIKYLGAFLHQYSKKAETLYV 81 
                     445566666777777777777777666666654.455688999999999999999988866 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 1.4e-07
  Pkinase_fungal 316 IkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhDLESffyvll 405
                      +g++ L+ + +i+HrD   +Nili         +g+L   D+ ++    ++ s a+++ GT+ Fm+ e+l++e      D+ Sf  +ll
      EFC39402.1 120 AEGLNYLH-ENNIIHRDLKPQNILID-------ASGVLKIGDFGISRVL-DTLSMAKTQCGTIDFMSYEMLNKEFYDQSTDMYSFGVILL 200
                     57888999.****************9.......5666665555555554.45566688**************776888888888866665 PP

>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.0   2.7e-06    0.0049      55     117 .]     578     647 ..     561     647 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 2.7e-06
                     T......TSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHTTESEEEEEEETT..EHHHHHHHHHTTE CS
  Acetyltransf_1  55 d......ekggvayieslaVspeyrgkGlGsaLlealeerareegikkivlaveed..ndaairlYeklGF 117
                     +      ++++++ +  laV+p+ r+kGlG + l  +++   e  +   +  v +d      + +++k+GF
      EFC39402.1 578 HnslissPHKPHWTLLALAVKPKLRKKGLGNEVLMPIIKSSDEASLPI-YTFVYKDegYSSVVDFLKKHGF 647
                     3445555889************************99998665555533.4444444103333777766776 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.32   5.7e+02      16      53 ..       6      44 ..       2      64 .. 0.80
   2 !   14.4   0.0   9.8e-06     0.018     136     189 ..     104     155 ..      70     201 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.32
  Kinase-like 16 rgellkkgdrsvvfevkdqetgeplavkvfllps.eask 53
                 + ++l++g ++ v++++ ++t e++a+k     s + ++
   EFC39402.1  6 VIKILGRGSEGQVVLAEHKKTEEQIAIKRMEWSSlDEAN 44
                 56899**********************988776655555 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 9.8e-06
  Kinase-like 136 ethkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggft 189
                  e++ k+++i    +  q+     +L+++ ++h +++++n+l d  g l++g+f+
   EFC39402.1 104 ERKMKEKDIVNYAI--QIAEGLNYLHENNIIHRDLKPQNILIDASGVLKIGDFG 155
                  23334444444443..445555799***************************97 PP

>> Seadorna_VP7  Seadornavirus VP7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.1   4.1e-06    0.0073     136     187 ..     101     154 ..      95     170 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 4.1e-06
  Seadorna_VP7 136 Cykirvlt....vniivaglkdLmdfhsestnllhGDcnpenlmcDknGylklvDP 187
                   C k r +     vn  +   + L+ +h  ++n++h D +p+n++ D  G+lk+ D 
    EFC39402.1 101 CKKERKMKekdiVNYAIQIAEGLNYLH--ENNIIHRDLKPQNILIDASGVLKIGDF 154
                   555555431111454444457899999..889*********************885 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   2.1e-05     0.038      56     120 ..     594     661 ..     570     666 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.1e-05
  Acetyltransf_10  56 llfVdpeyrgqGigkaLleaveeeaekdgikleltvnasp...yavpfYeklGFkavgeeqeenGirf 120
                       l+V+p+ r++G+g++ l+ +++  +++ + + + v ++      v+f +k+GF++ +e + e+G ++
       EFC39402.1 594 ALAVKPKLRKKGLGNEVLMPIIKSSDEASLPIYTFVYKDEgysSVVDFLKKHGFEVRDEHKPEQGPSL 661
                      579*********************9888776688888776534579***********99998888665 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   0.0   2.2e-05     0.039      29      75 ..     592     648 ..     567     649 .. 0.64

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 2.2e-05
                     E..EEE-GGGTTSSHHHHHHH.H.....TTSEEE...EE.EEEETHH...HHHHHHHHTTEE CS
  Acetyltransf_7  29 r..laVdpeyrgkGiGraLle.a.....aekgii...le.qlelnae...kaikfYeklGFe 75 
                        laV+p+ r+kG+G + l  +     +        ++  ++ + e     ++f +k+GFe
      EFC39402.1 592 LlaLAVKPKLRKKGLGNEVLMpIikssdE----AslpIYtFVYKD-EgysSVVDFLKKHGFE 648
                     1459**************99754233221....022222222222.12345588*******8 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   1.9e-05     0.034     107     155 ..      99     147 ..      24     158 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.9e-05
         Kdo 107 dllakwaelaeelkrallkavgrliaklhragvnHadlyaknillqqee 155
                 + ++k ++++e+   +   +++   + lh+ ++ H+dl ++nil+++ +
  EFC39402.1  99 TTCKKERKMKEKDIVNYAIQIAEGLNYLHENNIIHRDLKPQNILIDASG 147
                 333333334444444445688888999******************9876 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.8   3.3e+03      39      92 ..      48     113 ..       7     128 .. 0.61
   2 ?   10.3   0.0   0.00026      0.47     167     185 ..     130     147 ..     113     161 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.8
                 HHHHHHHHHHHTT-..B--B-CTTBS-EEETTEEEEEEE----EE-SS..........HHHHHHHH CS
         APH  39 revallrlLakagv..pvPevlagdtddeeigllfalieyvpgrsllr..........klsaaqlp 92 
                 +e++ lr+L+ ++v  +  + l+     +e +++ + iey+pg +l            k+ ++++ 
  EFC39402.1  48 NEAQKLRNLSHRNVikYLGAFLHQYSKKAETLYVCLCIEYCPGGDLQKlitttckkerKMKEKDIV 113
                 666667777777666555555565577777788888999999988877665555555555555555 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00026
                 EEE-SS-SGGGEEEC..TT CS
         APH 167 vllHgDlhpgNllvdpddg 185
                  ++H+Dl+p+N+l+d + g
  EFC39402.1 130 NIIHRDLKPQNILID-ASG 147
                 589************.333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (669 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       968  (0.0539907); expected 358.6 (0.02)
Passed bias filter:                      595  (0.0331865); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.72u 0.38s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 3769.98
//
Query:       EFC39403.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.046   13.9   0.0       0.15   12.2   0.0    2.0  1  UvrB_inter  UvrB interaction domain


Domain annotation for each model (and alignments):
>> UvrB_inter  UvrB interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   8.4e-06      0.15      18      55 ..       3      40 ..       1      58 [. 0.80

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 8.4e-06
  UvrB_inter 18 LvelqYer.ndvelkrGtFrvrGdtveifpasaeevair 55
                L+++q++    ve krG+ +++G+ ++i p+++ e++ r
  EFC39403.1  3 LEDVQFHApVVVEKKRGSLSLEGSSIDIAPPQK-ETISR 40
                66777776466799******************5.66555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       789  (0.0440069); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.25s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 2276.47
//
Query:       EFC39404.1  [L=602]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.6e-43  147.0   0.1      1e-42  146.4   0.1    1.3  1  Pyr_redox_2   Pyridine nucleotide-disulphide oxidoreductase
    1.2e-11   43.6   2.8    4.6e-05   22.7   0.2    2.6  2  EF-hand_5     EF hand
    3.7e-11   43.4   0.6    7.4e-10   39.3   0.7    2.8  2  Pyr_redox     Pyridine nucleotide-disulphide oxidoreductase
    4.1e-11   41.6   1.5    0.00018   20.8   0.1    2.6  2  EF-hand_1     EF hand
    1.1e-10   41.8   0.2    0.00082   19.8   0.0    3.1  3  EF-hand_7     EF-hand domain pair
    1.2e-08   34.2   1.3     0.0012   18.6   0.2    2.6  2  EF-hand_6     EF-hand domain
    0.00013   21.7   0.1       0.29   11.0   0.0    2.6  2  EF-hand_8     EF-hand domain pair
     0.0016   18.6   0.1      0.009   16.2   0.2    2.3  2  Dockerin_1    Dockerin type I domain
  ------ inclusion threshold ------
      0.013   15.8   3.2        2.6    8.4   0.1    2.9  3  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
      0.023   14.7   0.1         17    5.5   0.0    3.4  3  EF-hand_4     Cytoskeletal-regulatory complex EF hand


Domain annotation for each model (and alignments):
>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  146.4   0.1   5.6e-46     1e-42       1     288 [.      86     425 ..      86     429 .. 0.90

  Alignments for each domain:
  == domain 1  score: 146.4 bits;  conditional E-value: 5.6e-46
                  CSEEEE--SHHHHHHHHHHHHHTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHH......HHHHCHHHHCCCCHCCTCEEEEESCEEEEETEEEC CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2   1 kdvvviGgGpAGlaaaltlaqagakvtlvelegtclnggcllskallgvaedaeias......evvkklnqgielllgeevvkidpgkkkvklekkke 92 
                  k++v++G+G+A + + + +    ++v++v + ++ ++++++l+ al+g+ + ++i +      + v+k ++ ie++ + e+ ++d++++ +k+++ ++
   EFC39404.1  86 KKLVILGSGWASVGLIQSIDLDLYDVYVV-SPRNYFLFTPMLPAALAGTVSMQSITEpirsviNRVRKDKSLIEYYEA-ECYDVDYERGVIKCKDISN 181
                  589**************************.999999999***************999***777555555555666666.**************66555 PP

                  ...........TCEEEEEESEEEE---EEE-BCTCTTC.TTBEECCSECHHHHHHCCSS-T..................SEEEEES-SHHHHHHHHHH CS
                  ...........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2  93 ...........gdeekiaydklvlAtGssprdlgipGvaenvgklvrtldsaealklkllp..................krivvvGgGyiGvElAaal 161
                              + ++++ydklv+A Gs+p+ +g++Gv ++ + + +  ++a ++++kll+                   ++vvvGgG  G+E+ ++l
   EFC39404.1 182 yvihhqngsdiANDFELKYDKLVIAVGSQPNSFGVKGVDQYSVPM-KQPEHAVKIREKLLDvlesacmpnltdeerqkaLSVVVVGGGHAGIETLGYL 278
                  ***********999************************8888877.9***************************99998899**************** PP

                  HHHT-...............EEEEEESSSSSSTTS-HHHHHHHHHHHHHTTEEEEESCEEEEEEETTEEEEEEETTSCE......EEESEEEE-S-EE CS
                  xxxxx...............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxx RF
  Pyr_redox_2 162 aklgk...............evtlveardrllraldkelsaaleealekeGvevklgtsvkeidgngeklevvledgee......idadlvvvavGvr 238
                   ++ k               ++t+++  d++l+++d ++s+++e+++  ++v++k++++v+e+++n+    vv +d+++      ++   +++ +Gv 
   EFC39404.1 279 VDFVKedisklfpkdiveklKITVIHSSDHILNTYDCKISEMCEKEFIFNNVDLKTNARVVEVRENDL--VVVFKDQQKksepvsLPFGVCIWTTGVA 374
                  999888999999999999999*******************************************9996..444444444457888************* PP

                  ES-HHCS.HCCT-EEEETTEEE--TTSBES.STTEEE-GGGCTECCSS--HH CS
                  xxxxxxx.xxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 239 pstelle.eklglelderggivvdeflrtn.vpgiyaiGDvaggkggpelaq 288
                    +  ++  +   + ++   +vvd +l++    ++yaiGD+  + ++p+l+q
   EFC39404.1 375 QVPLVKKlAENIYKQKNEKSLVVDAHLQVVgLNNVYAIGDCS-KIDQPKLVQ 425
                  **99988966667778999*********866***********.889999887 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.2   1.2e-07   0.00021       4      24 ..     430     450 ..     428     451 .. 0.90
   2 !   22.7   0.2   2.5e-08   4.6e-05       1      24 [.     468     491 ..     468     492 .. 0.94

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.2e-07
                 HHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5   4 tFqaiDlNgDGkIskeELktl 24 
                 +F+++D N+DG Is+ E + l
  EFC39404.1 430 FFEQADINKDGVISFTEMESL 450
                 7****************9876 PP

  == domain 2  score: 22.7 bits;  conditional E-value: 2.5e-08
                 HHHHHHHH-SS-SSCE-HHHHHHH CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIskeELktl 24 
                 lk++F ++D+NgD  +sk+E+k l
  EFC39404.1 468 LKKLFTQADVNGDNVLSKDEFKSL 491
                 789******************987 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0       0.6   1.1e+03       1      44 [.      87     132 ..      87     154 .. 0.76
   2 !   39.3   0.7   4.1e-13   7.4e-10       1      78 [.     261     350 ..     261     354 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.6
                 EEEEECSSHHHHHHHHHHHHTTSEEEEEESSSSSS..TTSSHHHHH CS
   Pyr_redox   1 kvvvvGgGyiglElAgalaelgkkVtvversdkll..rllDeeask 44 
                 k+v++G+G+  + l + +     +V+vv  ++ +l  ++l+++++ 
  EFC39404.1  87 KLVILGSGWASVGLIQSIDLDLYDVYVVSPRNYFLftPMLPAALAG 132
                 5789999998888888876555699999999999976666666654 PP

  == domain 2  score: 39.3 bits;  conditional E-value: 4.1e-13
                 EEEEECSSHHHHHHHHHH.............HHTT..SEEEEEESSSSSSTTSSHHHHHHHHHHHHHTTEEEECSEEEEEEEEETTSEEEEEE CS
   Pyr_redox   1 kvvvvGgGyiglElAgal.............aelg..kkVtvversdkllrllDeeaskilqeklekngievllntkveeiegsedgvesvkl 78 
                 +vvvvGgG  g+E  g+l             +++    k+tv++ sd++l+ +D ++s+++++++  n++++ +n++v+e+++++  v  v++
  EFC39404.1 261 SVVVVGGGHAGIETLGYLvdfvkedisklfpKDIVekLKITVIHSSDHILNTYDCKISEMCEKEFIFNNVDLKTNARVVEVRENDL-V--VVF 350
                 69****************777776665555544436679*******************************************9885.2..555 PP

>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.2   2.8e-07    0.0005       3      28 ..     428     453 ..     426     454 .. 0.90
   2 !   20.8   0.1   9.8e-08   0.00018       2      28 ..     468     494 ..     467     495 .. 0.93

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.8e-07
                 HHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   3 keiFrefDkDgdGkIdfeEfkellkk 28 
                 + +F+ +D ++dG I+f E+ +l+k+
  EFC39404.1 428 ESFFEQADINKDGVISFTEMESLIKA 453
                 679*****************999885 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 9.8e-08
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 lk++F  +D++gd  ++++Efk+l+++
  EFC39404.1 468 LKKLFTQADVNGDNVLSKDEFKSLIQR 494
                 89*********************9876 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       4.3   7.8e+03      40      60 ..     319     337 ..     296     339 .. 0.71
   2 !   19.8   0.0   4.6e-07   0.00082      36      70 ..     417     451 ..     379     452 .. 0.79
   3 !   18.6   0.0     1e-06    0.0019       2      32 ..     466     496 ..     465     515 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 4.3
   EF-hand_7  40 klsdeelellfkefDtdkdGv 60 
                 ++ ++e   +f+++D+  + +
  EFC39404.1 319 EMCEKE--FIFNNVDLKTNAR 337
                 445544..8999999887755 PP

  == domain 2  score: 19.8 bits;  conditional E-value: 4.6e-07
   EF-hand_7  36 gegsklsdeelellfkefDtdkdGvisfdEFlkly 70 
                   + ++  ++ e +f+  D +kdGvisf+E++ l+
  EFC39404.1 417 KIDQPKLVQKYESFFEQADINKDGVISFTEMESLI 451
                 5566677799*********************9875 PP

  == domain 3  score: 18.6 bits;  conditional E-value: 1e-06
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkif 32 
                 +klk  F + D++gd+ l+k+e+++l+++i+
  EFC39404.1 466 QKLKKLFTQADVNGDNVLSKDEFKSLIQRID 496
                 699*************************986 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.1   2.2e-05     0.039       3      27 ..     428     452 ..     426     455 .. 0.91
   2 !   18.6   0.2   6.7e-07    0.0012       1      27 [.     467     493 ..     467     499 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.2e-05
   EF-hand_6   3 reaFklfDkdgdGkidaeElrkalr 27 
                 +++F++ D ++dG i++ E+ ++++
  EFC39404.1 428 ESFFEQADINKDGVISFTEMESLIK 452
                 789*****************99887 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 6.7e-07
   EF-hand_6   1 elreaFklfDkdgdGkidaeElrkalr 27 
                 +l+++F + D++gd+ ++++E++++++
  EFC39404.1 467 KLKKLFTQADVNGDNVLSKDEFKSLIQ 493
                 5899*******************9987 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0    0.0015       2.7      30      47 ..     429     446 ..     424     450 .. 0.87
   2 !   11.0   0.0   0.00016      0.29      30      53 ..     470     493 ..     463     494 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0015
   EF-hand_8  30 ilfrefDtdgdGkisfeE 47 
                 + f  +D+++dG+isf+E
  EFC39404.1 429 SFFEQADINKDGVISFTE 446
                 558899**********99 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00016
   EF-hand_8  30 ilfrefDtdgdGkisfeEFcvlle 53 
                  lf  +D +gd+++s++EF  l +
  EFC39404.1 470 KLFTQADVNGDNVLSKDEFKSLIQ 493
                 59*****************99866 PP

>> Dockerin_1  Dockerin type I domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.0    0.0024       4.3      34      55 ..     431     452 ..     424     453 .. 0.83
   2 !   16.2   0.2     5e-06     0.009       2      57 ..     434     495 ..     433     496 .. 0.95

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0024
                 HGGGSTT-SSCESHHHHHHHHH CS
  Dockerin_1  34 gkaaDvNgDGrvnalDallvin 55 
                  + aD+N+DG ++ + +  +i+
  EFC39404.1 431 FEQADINKDGVISFTEMESLIK 452
                 5789********9999988887 PP

  == domain 2  score: 16.2 bits;  conditional E-value: 5e-06
                 TETTSSSC-SHHHHHHHHHHCT......SSEBTTSCCCHGGGSTT-SSCESHHHHHHHHHHH CS
  Dockerin_1   2 gDVNgDgkVnalDalliinyln......qregqssssngkaaDvNgDGrvnalDallvinyL 57 
                 +D+N+Dg+++ + +  +i++ +      ++++q+ ++  + aDvNgD+  ++  +  +i+++
  EFC39404.1 434 ADINKDGVISFTEMESLIKAKEkeypnfATINQKLKKLFTQADVNGDNVLSKDEFKSLIQRI 495
                 7*************************************************999999999987 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.1       1.8   3.2e+03      86     104 ..     318     337 ..     304     344 .. 0.69
   2 ?    6.2   0.0    0.0068        12      91     110 ..     428     447 ..     416     449 .. 0.88
   3 ?    8.4   0.1    0.0015       2.6      43      83 ..     455     495 ..     449     499 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 1.8
  SPARC_Ca_bdg  86 lehCikpf.lescDadkdkk 104
                    e+C k+f +++ D++++ +
    EFC39404.1 318 SEMCEKEFiFNNVDLKTNAR 337
                   57777777456777766655 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0068
  SPARC_Ca_bdg  91 kpflescDadkdkkislkEw 110
                   + f+e++D +kd+ is +E 
    EFC39404.1 428 ESFFEQADINKDGVISFTEM 447
                   689************99985 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0015
  SPARC_Ca_bdg  43 keeeknlkeckepvawkFsklDtnsdkvlsksELaplrapl 83 
                   ++e  n ++++++++  F++ D+n d+vlsk E ++l + +
    EFC39404.1 455 EKEYPNFATINQKLKKLFTQADVNGDNVLSKDEFKSLIQRI 495
                   4555566778888889999**************99998765 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.34   6.1e+02      52      70 ..     190     208 ..     172     240 .. 0.72
   2 ?    4.0   0.0     0.027        49      43      65 ..     425     447 ..     388     454 .. 0.74
   3 ?    5.5   0.0    0.0092        17      42      67 ..     465     490 ..     458     509 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.34
   EF-hand_4  52 adidedgkldfeefciamr 70 
                 +di +d +l +++++ia+ 
  EFC39404.1 190 SDIANDFELKYDKLVIAVG 208
                 89************99974 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.027
   EF-hand_4  43 dklekiwdladidedgkldfeef 65 
                 +k e+ ++ adi++dg + f e+
  EFC39404.1 425 QKYESFFEQADINKDGVISFTEM 447
                 345678999***********996 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0092
   EF-hand_4  42 edklekiwdladidedgkldfeefci 67 
                 ++kl+k+++ ad++ d+ l  +ef  
  EFC39404.1 465 NQKLKKLFTQADVNGDNVLSKDEFKS 490
                 689********************964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (602 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       817  (0.0455686); expected 358.6 (0.02)
Passed bias filter:                      499  (0.027832); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 3458.52
//
Query:       EFC39405.1  [L=344]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        7.1    6.0  18.7       0.37   10.2   0.3    3.2  3  PBP_sp32  Proacrosin binding protein sp32


Domain annotation for each model (and alignments):
>> PBP_sp32  Proacrosin binding protein sp32
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   5.2     0.053   9.5e+02     150     203 ..       2      54 ..       1      64 [. 0.69
   2 ?   10.2   0.3   2.1e-05      0.37     158     229 ..      76     147 ..      57     156 .. 0.87
   3 ?    5.5   0.7   0.00056        10     188     229 ..     301     342 ..     283     344 .] 0.79

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.053
    PBP_sp32 150 etPivteatstekeafqpwperllnnveellksslslggkekapeakpkeeqll 203
                   P  +  +s+e++       r +++ve+  + + s    +ka+++  + eq l
  EFC39405.1   2 SPPSASSSSSSEQQEASVLGKRSNDQVENSKEEDSSESQSKKATSS-SNMEQSL 54 
                 56888999999999999999*******9977666666445555543.3444434 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 2.1e-05
    PBP_sp32 158 tstekeafqpwperllnnveellksslslggkekapeakpkeeqllekkqeqleehkteekkkqeeqeeeek 229
                 ++ e  +++ +    l ++e+++ks++    + k+p+     e  l+  +eq+ee k+ ++++++  +  ek
  EFC39405.1  76 GVGEYTTYECFSYDELPKIEDIYKSEEGDECQFKQPSFDGTWEWKLKSMKEQIEEFKQLRGNEKRKNNKREK 147
                 567778888888888999*******************99999999***************999998887775 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.00056
    PBP_sp32 188 gkekapeakpkeeqllekkqeqleehkteekkkqeeqeeeek 229
                 gk k  + k k  q    + e+l++ k+  ++kq+e++eee 
  EFC39405.1 301 GKMKPIDIKYKPGQRYALHYENLQKAKQSTTQKQDEKKEEET 342
                 6666666666666666778899**************999984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (344 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1811  (0.10101); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2053.48
//
Query:       EFC39406.1  [L=5468]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   2.7e-143  465.9 1047.5    5.7e-05   23.4   6.1   66.2 66  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.7   5.7   9.4e-08    0.0017       7      32 .]      42      66 ..      37      66 .. 0.92
   2 !    7.9   5.4   0.00022         4      14      32 .]      87     104 ..      83     104 .. 0.87
   3 !   20.6   9.3   2.3e-08   0.00042       5      32 .]     117     143 ..     114     143 .. 0.90
   4 !   16.3   6.2   5.3e-07    0.0095       5      32 .]     156     182 ..     152     182 .. 0.91
   5 !   20.0  10.0   3.7e-08   0.00067       5      32 .]     200     226 ..     197     226 .. 0.91
   6 !   17.4   8.7   2.4e-07    0.0043       5      32 .]     239     265 ..     235     265 .. 0.91
   7 !   20.0  10.0   3.7e-08   0.00067       5      32 .]     283     309 ..     280     309 .. 0.91
   8 !   17.7   7.4   1.9e-07    0.0035       5      32 .]     322     348 ..     318     348 .. 0.91
   9 !   10.8  11.3   2.7e-05      0.49       5      32 .]     366     392 ..     363     392 .. 0.87
  10 !    4.3   8.9    0.0029        53       5      32 .]     405     431 ..     397     431 .. 0.89
  11 !   15.7   9.5     8e-07     0.014       6      32 .]     445     470 ..     436     470 .. 0.85
  12 !    8.8  10.7   0.00011       2.1       5      32 .]     710     736 ..     702     736 .. 0.78
  13 !    7.1   8.0    0.0004       7.2       6      32 .]     750     776 ..     746     776 .. 0.87
  14 !    4.1  11.4    0.0034        60       6      32 .]     790     817 ..     785     817 .. 0.77
  15 ?   -2.8   6.8      0.48   8.7e+03       7      27 ..     821     849 ..     817     852 .. 0.57
  16 !   12.5   7.9   8.3e-06      0.15       5      32 .]    1076    1102 ..    1072    1102 .. 0.88
  17 !   15.2  10.3   1.1e-06     0.021       7      32 .]    1117    1141 ..    1112    1141 .. 0.87
  18 !    6.5   5.5   0.00063        11       7      32 .]    1156    1182 ..    1151    1182 .. 0.87
  19 !    9.1  11.5   9.2e-05       1.7       7      32 .]    1193    1219 ..    1187    1219 .. 0.89
  20 !   11.6   8.4   1.5e-05      0.27       4      32 .]    1231    1258 ..    1229    1258 .. 0.92
  21 !   14.7   9.0   1.7e-06     0.031       5      32 .]    1271    1297 ..    1263    1297 .. 0.86
  22 !   11.5   9.6   1.7e-05       0.3       7      32 .]    1312    1336 ..    1307    1336 .. 0.88
  23 !   19.2   6.2   6.6e-08    0.0012       5      32 .]    1350    1376 ..    1346    1376 .. 0.91
  24 !   17.8   4.4   1.8e-07    0.0032       5      32 .]    1389    1415 ..    1385    1415 .. 0.90
  25 !    8.2   4.5   0.00018       3.2       6      32 .]    1429    1456 ..    1424    1456 .. 0.86
  26 !   16.0   8.1   6.3e-07     0.011       5      32 .]    1469    1495 ..    1465    1495 .. 0.86
  27 !   10.6   8.0   3.1e-05      0.56       6      32 .]    1509    1534 ..    1505    1534 .. 0.84
  28 !    9.3   8.1     8e-05       1.4       5      32 .]    1547    1573 ..    1539    1573 .. 0.85
  29 !   12.8   7.9   6.6e-06      0.12       5      32 .]    1587    1613 ..    1582    1613 .. 0.86
  30 !   16.1   9.6     6e-07     0.011       3      32 .]    1624    1652 ..    1623    1652 .. 0.87
  31 !   13.2   7.0   4.7e-06     0.085       5      32 .]    1665    1691 ..    1661    1691 .. 0.88
  32 !   23.4   6.1   3.2e-09   5.7e-05       7      32 .]    1706    1730 ..    1700    1730 .. 0.94
  33 !   17.4   5.6   2.4e-07    0.0044       5      32 .]    1744    1770 ..    1739    1770 .. 0.88
  34 !    6.7   9.2   0.00054       9.6       6      32 .]    1784    1809 ..    1780    1809 .. 0.86
  35 !   15.0   8.2   1.3e-06     0.024       4      32 .]    1821    1849 ..    1818    1849 .. 0.89
  36 !   13.6   4.4   3.6e-06     0.064       7      32 .]    1864    1888 ..    1859    1888 .. 0.89
  37 !   16.5   9.1   4.4e-07    0.0079       5      32 .]    1901    1927 ..    1897    1927 .. 0.91
  38 !   16.5   8.3   4.5e-07     0.008       5      32 .]    1940    1966 ..    1936    1966 .. 0.90
  39 !   12.4  11.6   8.9e-06      0.16       5      32 .]    1979    2005 ..    1971    2005 .. 0.85
  40 !   11.1   8.7   2.2e-05      0.39       5      32 .]    2018    2044 ..    2014    2044 .. 0.86
  41 !   12.4   8.0   8.8e-06      0.16       5      32 .]    2057    2083 ..    2049    2083 .. 0.85
  42 !   21.3   9.6   1.4e-08   0.00025       5      32 .]    2096    2122 ..    2093    2122 .. 0.89
  43 !   14.0   9.6   2.7e-06     0.049       4      32 .]    2133    2161 ..    2131    2161 .. 0.91
  44 !   17.4   8.3   2.4e-07    0.0043       7      32 .]    2176    2200 ..    2170    2200 .. 0.93
  45 !    4.9   9.6     0.002        35       4      32 .]    2212    2240 ..    2209    2240 .. 0.88
  46 !    7.4   9.6   0.00032       5.8       5      32 .]    2253    2279 ..    2245    2279 .. 0.86
  47 !   17.7   9.8   1.9e-07    0.0034       4      32 .]    2291    2318 ..    2288    2318 .. 0.91
  48 !   14.1   7.7   2.6e-06     0.046       6      32 .]    2332    2357 ..    2328    2357 .. 0.86
  49 !    8.9   7.4   0.00011         2       6      28 ..    2371    2392 ..    2362    2396 .. 0.82
  50 !   16.5   9.1   4.4e-07    0.0079       5      32 .]    2409    2435 ..    2405    2435 .. 0.91
  51 !   19.3   7.8   5.9e-08    0.0011       5      32 .]    2448    2474 ..    2444    2474 .. 0.90
  52 !   13.1  11.3   5.2e-06     0.094       5      32 .]    2487    2513 ..    2479    2513 .. 0.85
  53 !   11.8   7.3   1.4e-05      0.25       4      32 .]    2525    2552 ..    2522    2552 .. 0.89
  54 !   16.0   4.5   6.6e-07     0.012       5      32 .]    2565    2591 ..    2561    2591 .. 0.91
  55 !   17.4   8.3   2.4e-07    0.0043       7      32 .]    2606    2630 ..    2600    2630 .. 0.93
  56 !   12.4   6.7   8.6e-06      0.15       5      32 .]    2643    2669 ..    2639    2669 .. 0.89
  57 !   19.3   7.8   5.9e-08    0.0011       5      32 .]    2682    2708 ..    2678    2708 .. 0.90
  58 !   11.0   7.8   2.4e-05      0.43       5      32 .]    2721    2747 ..    2716    2747 .. 0.87
  59 !   22.1   8.7   8.2e-09   0.00015       6      32 .]    2761    2786 ..    2756    2786 .. 0.91
  60 !   16.3  12.4   5.4e-07    0.0097       5      32 .]    2799    2825 ..    2791    2825 .. 0.83
  61 !   18.2   7.8   1.3e-07    0.0023       6      32 .]    2839    2864 ..    2834    2864 .. 0.88
  62 !   14.5   9.1   1.9e-06     0.034       3      32 .]    2875    2903 ..    2873    2903 .. 0.87
  63 !   10.3  11.4     4e-05      0.71       5      32 .]    2916    2942 ..    2908    2942 .. 0.87
  64 !   11.5   5.4   1.6e-05      0.29       1      32 []    2951    2985 ..    2951    2985 .. 0.71
  65 ?   -2.4   1.3      0.37   6.6e+03      22      32 .]    2987    2997 ..    2984    2997 .. 0.88
  66 !    6.0   2.6   0.00089        16      14      32 .]    3667    3688 ..    3664    3688 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.7 bits;  conditional E-value: 9.4e-08
       EGF_2  7 iCgghGtCvnqcGqCdCdsgyqGktC 32
                 C+g+GtC++ +  C+C +gy+G++C
  EFC39406.1 42 VCSGNGTCIADE-TCSCLTGYSGNNC 66
                6*******9888.8************ PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.00022
       EGF_2  14 CvnqcGqCdCdsgyqGktC 32 
                 C ++  +C Cdsgy+G+ C
  EFC39406.1  87 CQSPD-NCLCDSGYYGPLC 104
                 88888.7***********9 PP

  == domain 3  score: 20.6 bits;  conditional E-value: 2.3e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g+G Cv+++ +C+C+s+y+G++C
  EFC39406.1 117 SRVCSGNGACVDLN-NCQCSSNYFGDDC 143
                 568********999.8************ PP

  == domain 4  score: 16.3 bits;  conditional E-value: 5.3e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ +G C ++  +C C +gy+G++C
  EFC39406.1 156 SLVCSSQGNCTALD-KCLCTDGYSGNNC 182
                 789********999.************* PP

  == domain 5  score: 20.0 bits;  conditional E-value: 3.7e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G Cv+++ +C+C+s+y+G++C
  EFC39406.1 200 STVCSGNGACVDLN-NCQCSSNYFGNDC 226
                 678********999.8************ PP

  == domain 6  score: 17.4 bits;  conditional E-value: 2.4e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C ++  +C+C +gy+G++C
  EFC39406.1 239 SLVCNGQGNCTALD-KCSCTDGYSGNNC 265
                 789********999.************* PP

  == domain 7  score: 20.0 bits;  conditional E-value: 3.7e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G Cv+++ +C+C+s+y+G++C
  EFC39406.1 283 STVCSGNGACVDLN-NCQCSSNYFGNDC 309
                 678********999.8************ PP

  == domain 8  score: 17.7 bits;  conditional E-value: 1.9e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C ++  +C C +gy+G++C
  EFC39406.1 322 SLVCNGQGNCTALD-KCLCTDGYSGNNC 348
                 789********999.************* PP

  == domain 9  score: 10.8 bits;  conditional E-value: 2.7e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C+ +  +C C  gy+G++C
  EFC39406.1 366 STVCSGNGDCIGSD-NCNCLYGYYGDKC 392
                 678********555.7************ PP

  == domain 10  score: 4.3 bits;  conditional E-value: 0.0029
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  + C   G C ++   C+C ++y+G +C
  EFC39406.1 405 ASVCTSLGNCTAPD-SCSCVDNYFGSNC 431
                 578********999.7************ PP

  == domain 11  score: 15.7 bits;  conditional E-value: 8e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghGtC++ + +C C++g+ G  C
  EFC39406.1 445 LVCSGHGTCISYN-NCTCQTGFIGEAC 470
                 68*******9555.8**********99 PP

  == domain 12  score: 8.8 bits;  conditional E-value: 0.00011
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+++G+C+  +  C C +  +G +C
  EFC39406.1 710 EDGCSNNGYCIGNN-TCLCLPDQYGQDC 736
                 556********334.7***********9 PP

  == domain 13  score: 7.1 bits;  conditional E-value: 0.0004
       EGF_2   6 eiCgg.hGtCvnqcGqCdCdsgyqGktC 32 
                 + C++ hG C+++   C+C ++y G  C
  EFC39406.1 750 SVCSNgHGACIAKD-TCSCYPNYNGTWC 776
                 568888*****888.9*********988 PP

  == domain 14  score: 4.1 bits;  conditional E-value: 0.0034
       EGF_2   6 eiCgghGtCvnqcGqCdC..dsgyqGktC 32 
                 + C+g+G+C+ + ++C C   +gy G +C
  EFC39406.1 790 DVCSGRGSCD-FYNNCTCnsTFGYGGFNC 817
                 47*******9.7889***55556656666 PP

  == domain 15  score: -2.8 bits;  conditional E-value: 0.48
       EGF_2   7 iCgg.hGtC.vnqcG......qCdCdsgy 27 
                 iC+g  G+C  +  G       C C  +y
  EFC39406.1 821 ICNGlTGVCtKDRRGicyrpdLCNCTENY 849
                 67777777755455733333257776665 PP

  == domain 16  score: 12.5 bits;  conditional E-value: 8.3e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++C g G+C++ + +C C+   +G++C
  EFC39406.1 1076 NLTCAGKGQCIDYN-KCICKEDSYGDDC 1102
                  789*******8555.************* PP

  == domain 17  score: 15.2 bits;  conditional E-value: 1.1e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+ghG C     +C+Cd+gy+G  C
  EFC39406.1 1117 VCSGHGNCAGRD-KCVCDFGYYGQMC 1141
                  7********555.8*********999 PP

  == domain 18  score: 6.5 bits;  conditional E-value: 0.00063
       EGF_2    7 iCgghGtCvnqcGqCdC..dsgyqGktC 32  
                  +C+ +G+C+ + ++C C    gy G++C
  EFC39406.1 1156 ACNKRGVCE-FYNNCTCnlTLGYGGPDC 1182
                  7*******8.6889***88889999999 PP

  == domain 19  score: 9.1 bits;  conditional E-value: 9.2e-05
       EGF_2    7 iCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                   C+g  +G C++++ +C+C +gy+Gk C
  EFC39406.1 1193 LCSGagRGDCISPN-NCSCADGYYGKWC 1219
                  588888*****999.8**********98 PP

  == domain 20  score: 11.6 bits;  conditional E-value: 1.5e-05
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ Cg  G C ++  +C+C  gy+G tC
  EFC39406.1 1231 NSSVCGEKGNCTAFD-KCSCLEGYYGHTC 1258
                  5789********999.************* PP

  == domain 21  score: 14.7 bits;  conditional E-value: 1.7e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +e+C+g G+Cvn    C+C++ ++G +C
  EFC39406.1 1271 NETCSGKGSCVNYD-TCVCQPEFYGINC 1297
                  899*******9444.7************ PP

  == domain 22  score: 11.5 bits;  conditional E-value: 1.7e-05
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+ghG+Cv +   C C ++y+G+ C
  EFC39406.1 1312 SCSGHGKCVGLD-TCNCTQNYYGPWC 1336
                  6********666.8*********988 PP

  == domain 23  score: 19.2 bits;  conditional E-value: 6.6e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C ++  +C+C +gy+G+ C
  EFC39406.1 1350 STVCSGRGSCSRFD-VCSCLDGYYGPRC 1376
                  678********999.************* PP

  == domain 24  score: 17.8 bits;  conditional E-value: 1.8e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   e C+g GtC+++   C+C++ y+G+ C
  EFC39406.1 1389 TEVCNGVGTCIDLD-ICVCPNTYSGDFC 1415
                  689********999.9************ PP

  == domain 25  score: 8.2 bits;  conditional E-value: 0.00018
       EGF_2    6 eiCgghGtCvnqcGqCdC..dsgyqGktC 32  
                  + C+g+G C ++   C C    gy G +C
  EFC39406.1 1429 SVCSGRGFCTHLD-ICNCdeTLGYEGSNC 1456
                  57********999.9***76679999999 PP

  == domain 26  score: 16.0 bits;  conditional E-value: 6.3e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG+C  +   C+Cd+gy+G +C
  EFC39406.1 1469 STVCSSHGSCTGAD-HCSCDTGYFGSNC 1495
                  578********444.6************ PP

  == domain 27  score: 10.6 bits;  conditional E-value: 3.1e-05
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C+ hG C +  ++C C+ gy+G  C
  EFC39406.1 1509 QVCSRHGFCATY-NNCTCNLGYSGSIC 1534
                  57*******944.58*********988 PP

  == domain 28  score: 9.3 bits;  conditional E-value: 8e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+g+G C +    C+C s  +G++C
  EFC39406.1 1547 KAVCSGRGNCSDID-TCVCLSDAYGDDC 1573
                  567*******7555.8************ PP

  == domain 29  score: 12.8 bits;  conditional E-value: 6.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ +G+C+ +   C C  gy+Gk C
  EFC39406.1 1587 NIVCSSRGHCIGTD-SCNCTEGYYGKFC 1613
                  568********555.5************ PP

  == domain 30  score: 16.1 bits;  conditional E-value: 6e-07
       EGF_2    3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  a+++ C+g+G C +  +qC C+ gy+G++C
  EFC39406.1 1624 ANKSVCSGRGLCSDY-NQCNCSEGYYGDNC 1652
                  56789*******745.5************* PP

  == domain 31  score: 13.2 bits;  conditional E-value: 4.7e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ghG C ++  +C+C s+y+G +C
  EFC39406.1 1665 SKVCSGHGLCSRTD-ECKCASNYFGLNC 1691
                  568*******9777.9*********999 PP

  == domain 32  score: 23.4 bits;  conditional E-value: 3.2e-09
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g+G C +++ qC+C  gy+G++C
  EFC39406.1 1706 VCSGRGECLSPN-QCSCREGYYGDYC 1730
                  6*******9999.************* PP

  == domain 33  score: 17.4 bits;  conditional E-value: 2.4e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C + +  C Cd+  +G++C
  EFC39406.1 1744 QLVCSGRGQCSDMN-TCICDPDAYGPDC 1770
                  789*******8777.9************ PP

  == domain 34  score: 6.7 bits;  conditional E-value: 0.00054
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C+g+G+C+++   C C  + +G  C
  EFC39406.1 1784 IVCSGRGQCIETD-HCNCTENNYGQFC 1809
                  67*******9666.8*********999 PP

  == domain 35  score: 15.0 bits;  conditional E-value: 1.3e-06
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    d++C+g G+C +++  C+C+ + +G +C
  EFC39406.1 1821 QtDLTCSGKGVCAQFN-SCQCFENSFGSDC 1849
                  2689*********899.7************ PP

  == domain 36  score: 13.6 bits;  conditional E-value: 3.6e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +C+ +G+C +++ +C+C+ +y G+ C
  EFC39406.1 1864 ACHSRGSCMSTN-NCSCFLNYLGDEC 1888
                  6*******7555.8************ PP

  == domain 37  score: 16.5 bits;  conditional E-value: 4.4e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g G+C ++   C Cd gy+G++C
  EFC39406.1 1901 TNVCSGKGQCADFD-SCACDEGYYGDNC 1927
                  579*******9999.7************ PP

  == domain 38  score: 16.5 bits;  conditional E-value: 4.5e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ +G+C + + +C+Cd gy+G++C
  EFC39406.1 1940 SSVCSSRGHCTSYE-KCECDEGYFGNNC 1966
                  578*******9777.9************ PP

  == domain 39  score: 12.4 bits;  conditional E-value: 8.9e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ +G C + + +C C ++y+G++C
  EFC39406.1 1979 STVCSSRGECSSYN-NCTCRDNYFGNDC 2005
                  578*******9555.8************ PP

  == domain 40  score: 11.1 bits;  conditional E-value: 2.2e-05
       EGF_2    5 deiCgghGtC.vnqcGqCdCdsgyqGktC 32  
                  +  C+  G+C +   + C C++gy+G  C
  EFC39406.1 2018 SKVCSSKGSCmD--YNICNCSAGYYGSEC 2044
                  789*******66..669************ PP

  == domain 41  score: 12.4 bits;  conditional E-value: 8.8e-06
       EGF_2    5 deiCgghGtCvnqcGq.CdCdsgyqGktC 32  
                  +++C+g+G C+   G+ C+C ++ +G+ C
  EFC39406.1 2057 NSTCSGRGDCI--DGNtCVCMANMFGPMC 2083
                  789*******9..6655*********999 PP

  == domain 42  score: 21.3 bits;  conditional E-value: 1.4e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ghG+Cv+ +  CdCd++y+G tC
  EFC39406.1 2096 SSVCSGHGSCVDVN-DCDCDTNYYGSTC 2122
                  789*******9777.9************ PP

  == domain 43  score: 14.0 bits;  conditional E-value: 2.7e-06
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+g G+C ++  +C+C+ +y G++C
  EFC39406.1 2133 NtSSVCSGFGKCASFD-RCQCEEHYNGNDC 2161
                  45789********999.************* PP

  == domain 44  score: 17.4 bits;  conditional E-value: 2.4e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+ +G C +++ +C+C ++y+G+tC
  EFC39406.1 2176 VCSSRGECSSFN-NCSCRDNYFGDTC 2200
                  7********999.8************ PP

  == domain 45  score: 4.9 bits;  conditional E-value: 0.002
       EGF_2    4 sdeiCgghGtCvnqcGqCdC.dsgyqGktC 32  
                  ++  C  +G C +++  C C + +y+G  C
  EFC39406.1 2212 NSKVCTSRGNCSDFN-TCNCsSINYFGTEC 2240
                  4789*******9999.9***888*****99 PP

  == domain 46  score: 7.4 bits;  conditional E-value: 0.00032
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C   G+Cv+   +CdC++gy+G  C
  EFC39406.1 2253 SSVCYSKGICVDYD-VCDCENGYFGGEC 2279
                  678*******9555.8*********999 PP

  == domain 47  score: 17.7 bits;  conditional E-value: 1.9e-07
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++ C+ +G C +++ +C+C ++y+G+tC
  EFC39406.1 2291 NSSVCSSRGECSSFN-NCSCRDNYFGDTC 2318
                  5789********999.8************ PP

  == domain 48  score: 14.1 bits;  conditional E-value: 2.6e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C+g G+C++ +  C+C+ gy+G+ C
  EFC39406.1 2332 YVCSGKGKCIDYN-TCVCKYGYFGDIC 2357
                  57*******8555.9*********988 PP

  == domain 49  score: 8.9 bits;  conditional E-value: 0.00011
       EGF_2    6 eiCgghGtCvnqc.GqCdCdsgyq 28  
                  + C+g+G C   + G C+C  +y 
  EFC39406.1 2371 LVCSGRGNCT--NfGDCKCRENYM 2392
                  57*******9..446****99996 PP

  == domain 50  score: 16.5 bits;  conditional E-value: 4.4e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g G+C ++   C Cd gy+G++C
  EFC39406.1 2409 TNVCSGKGQCADFD-SCACDEGYYGDNC 2435
                  579*******9999.7************ PP

  == domain 51  score: 19.3 bits;  conditional E-value: 5.9e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG+C + + +C+Cd gy+G++C
  EFC39406.1 2448 SSVCSTHGKCTSYE-KCECDEGYFGNDC 2474
                  578*******9777.9************ PP

  == domain 52  score: 13.1 bits;  conditional E-value: 5.2e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ +G C + + +C+C ++y+G tC
  EFC39406.1 2487 STVCSSRGECSSYN-NCSCRDNYFGSTC 2513
                  578*******9555.8************ PP

  == domain 53  score: 11.8 bits;  conditional E-value: 1.4e-05
       EGF_2    4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++  C  +G C +++  C+C+s ++G+ C
  EFC39406.1 2525 NSKVCTSRGNCSDFN-ICECKSDFYGPVC 2552
                  4789*******9999.**********998 PP

  == domain 54  score: 16.0 bits;  conditional E-value: 6.6e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+  G+C  ++ +C C+ gy+G++C
  EFC39406.1 2565 SSVCSTYGKCTIPE-VCICKEGYFGNDC 2591
                  578*******8799.9************ PP

  == domain 55  score: 17.4 bits;  conditional E-value: 2.4e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+ +G C +++ +C+C ++y+G+tC
  EFC39406.1 2606 VCSSRGECSSFN-NCSCRDNYFGDTC 2630
                  7********999.8************ PP

  == domain 56  score: 12.4 bits;  conditional E-value: 8.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C  +G C +++  C+C+s ++G+ C
  EFC39406.1 2643 STVCTSRGNCSDFN-ICECKSDFYGPVC 2669
                  789*******9999.**********998 PP

  == domain 57  score: 19.3 bits;  conditional E-value: 5.9e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG+C + + +C+Cd gy+G++C
  EFC39406.1 2682 SSVCSTHGKCTSYE-KCECDEGYFGNDC 2708
                  578*******9777.9************ PP

  == domain 58  score: 11.0 bits;  conditional E-value: 2.4e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ +G C + + +C C+++y G +C
  EFC39406.1 2721 SNSCSARGECSSYN-NCTCFTNYWGVDC 2747
                  567*******9555.8***********9 PP

  == domain 59  score: 22.1 bits;  conditional E-value: 8.2e-09
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ +G+C++++ +C+Cd gy+G+tC
  EFC39406.1 2761 TVCSSRGQCIDFN-NCSCDEGYYGPTC 2786
                  67********999.8************ PP

  == domain 60  score: 16.3 bits;  conditional E-value: 5.4e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C +   +C Cd+gy+G +C
  EFC39406.1 2799 NSVCSGRGKCSE-YSNCTCDTGYYGVNC 2825
                  899*******83.469**********99 PP

  == domain 61  score: 18.2 bits;  conditional E-value: 1.3e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+g+G+C + + +C+C ++y+G++C
  EFC39406.1 2839 SVCSGRGVCASYN-NCSCRPHYFGNDC 2864
                  57*******8555.8************ PP

  == domain 62  score: 14.5 bits;  conditional E-value: 1.9e-06
       EGF_2    3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++++ C+ +G+C++ + +C+C + y+G tC
  EFC39406.1 2875 NNNSVCSRRGQCIDYN-NCSCVDTYYGSTC 2903
                  4499********8566.8************ PP

  == domain 63  score: 10.3 bits;  conditional E-value: 4e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g G+Cv+    C C++gy G +C
  EFC39406.1 2916 KSVCSGKGKCVDID-TCNCKTGYNGTNC 2942
                  789*******9666.8************ PP

  == domain 64  score: 11.5 bits;  conditional E-value: 1.6e-05
       EGF_2    1 CsasdeiCgghGtC.vnqcGqCdC.....dsgyqGktC 32  
                  C+  + +C +hG C +   G C+C     +  ++G tC
  EFC39406.1 2951 CKK-EINCTNHGEClI--SGACECytdysQGFWTGFTC 2985
                  777.567*******66..79****65554444556666 PP

  == domain 65  score: -2.4 bits;  conditional E-value: 0.37
       EGF_2   22 dCdsgyqGktC 32  
                  +Cd+ y+G  C
  EFC39406.1 2987 KCDQDYYGELC 2997
                  69******999 PP

  == domain 66  score: 6.0 bits;  conditional E-value: 0.00089
       EGF_2   14 CvnqcG.....qCdCdsgyqGktC 32  
                  C+  +G      C+C++ + G +C
  EFC39406.1 3667 CI--NGvdiagSCKCKDEWIGQYC 3688
                  55..56444337************ PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (5468 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2251  (0.125551); expected 358.6 (0.02)
Passed bias filter:                      344  (0.0191868); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 3.13u 0.35s 00:00:03.48 Elapsed: 00:00:00.93
# Mc/sec: 17782.69
//
Query:       EFC39407.1  [L=507]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-45  154.4   0.0    4.9e-45  153.9   0.0    1.1  1  FMO-like       Flavin-binding monooxygenase-like
    4.3e-21   75.5   0.0    8.8e-18   64.6   0.0    2.1  2  Pyr_redox_3    Pyridine nucleotide-disulphide oxidoreductase
    3.3e-12   46.2   0.0    3.2e-10   39.7   0.0    2.6  3  K_oxygenase    L-lysine 6-monooxygenase (NADPH-requiring)
    2.3e-11   43.5   0.0    1.3e-09   37.7   0.0    2.1  2  Pyr_redox_2    Pyridine nucleotide-disulphide oxidoreductase
      8e-07   29.5   0.2    0.00068   20.1   0.0    2.8  3  Pyr_redox      Pyridine nucleotide-disulphide oxidoreductase
    4.4e-06   26.8   0.1    0.00016   21.8   0.0    2.6  2  NAD_binding_8  NAD(P)-binding Rossmann-like domain
     0.0077   15.8   0.0        3.2    7.2   0.0    3.1  3  DAO            FAD dependent oxidoreductase
  ------ inclusion threshold ------
      0.018   15.0   0.1          7    6.6   0.1    3.6  3  NAD_binding_9  FAD-NAD(P)-binding
      0.021   14.2   0.0        5.6    6.2   0.1    2.1  2  FAD_oxidored   FAD dependent oxidoreductase


Domain annotation for each model (and alignments):
>> FMO-like  Flavin-binding monooxygenase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  153.9   0.0   2.5e-48   4.9e-45       3     374 ..      62     413 ..      60     437 .. 0.88

  Alignments for each domain:
  == domain 1  score: 153.9 bits;  conditional E-value: 2.5e-48
    FMO-like   3 kvaviGaGvsGlasikccleegleptcfersddiGGlwrfkenveeGrasiyksvvsnsskemscfsdfplpedypnflhnsklleylklfakefdllk 101
                 k  ++G+G sGl s  +    g+     +  + iGG w            +y s  + ss+  + f d+p+p  +p f    +++ey++ + k++ +  
  EFC39407.1  62 KFLIVGCGFSGLGSSATLTRYGIPFDIVDTNNVIGGNWS---------VGVYESTHIISSRLTTEFKDYPMPSSFPQFPSCRQMMEYFHDYCKHYRIAE 151
                 67799*********9999999999999999999***996.........469************************************************ PP

    FMO-like 102 yiqfkttvcsvkkrpdfstsGqwevvtekegkkesavfdavmvctGhhvnphlplesfpGiekfkGqyfhsrdykepevfkgkrvlviGlGnsggdiav 200
                  + ++ttv s++      +  +++v  ek+g+k + ++  v++  Ghh    +p  s+ G  kf G ++hs+dykep++fk+krvlviG Gns++d+av
  EFC39407.1 152 RLSLETTVNSIEPVE--NKDSEYKVEFEKNGQKFTRIYKGVIINNGHHWCRRMP--SYEGQSKFTGLLIHSKDYKEPSIFKDKRVLVIGGGNSACDVAV 246
                 ***********8655..5677899****************************99..89***************************************** PP

    FMO-like 201 elsrtaeqvllstrsGswvlsrvsdsGypwdmllvtrfksllknilptalsnwlvekklnkrfnhe.nygl.kpkkralakepvlndelparilaGavk 297
                 e++r  ++  +s r+G + l r    G p   l+   +   l++i+ t ++      k+ + +++e +yg+ +p++r    +p++n el + +  G ++
  EFC39407.1 247 EAARYGKESHISIRRGYYFLPRTL-FGKPSVELIIPYLPLRLQQIIFTLIL------KITTGLDYEkDYGIpTPTHRLFETHPTINSELLQYLKLGEIH 338
                 **********************86.68887767666666666666555554......455566654279985799************************ PP

    FMO-like 298 vkssvkeltetsai.fedgtveedidvvifatGytfafpfleeslvkveknkvslykkvfpanlekptlaiiGliqpl 374
                  ++++k ++    + f++g  e + dv++ +tGy  + p+l++ + k e     l   +f +n  +  l  iGl qp+
  EFC39407.1 339 PHGDIKCFKGGNKVeFKNG-EEREFDVIVCCTGYFTSVPLLDNFVTKTEFGYPKLIHGIFVPN--RKNLIYIGLGQPR 413
                 *********8776626666.6788************************************997..6678889988875 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.6   0.0   4.4e-21   8.8e-18       1     196 [.      64     261 ..      64     299 .. 0.84
   2 !    9.0   0.0   0.00036      0.72     211     289 ..     321     392 ..     311     408 .. 0.72

  Alignments for each domain:
  == domain 1  score: 64.6 bits;  conditional E-value: 4.4e-21
  Pyr_redox_3   1 iIiGaGPaGlaaaielkkagledylilEkgni..gnsiyrypkemtfispsftsekleipdlnaiseetspafslkeeklsrkealeYlrevaksfel 96 
                  +I+G G  Gl++  +l + g+  + i++ +n+  gn     ++++ +is+  t+e   ++d ++  +++ p      + +s ++++eY+  ++k++++
   EFC39407.1  64 LIVGCGFSGLGSSATLTRYGI-PFDIVDTNNVigGNWSVGVYESTHIISSRLTTE---FKDYPM--PSSFP------QFPSCRQMMEYFHDYCKHYRI 149
                  6********************.8*******7644577778899999999776544...555443..44556......469999*************99 PP

  Pyr_redox_3  97 ..piklfeeVesvkk...edegfevetske..tye..AkkviiAtGefdkPnklnipGeek...lvkhyskvkefhkyagqkvvViGgknSavDaAle 182
                    +  l+++V+s+++   +d++++ve +k+  +++   k vii  G     ++++++G++k   l +h++ +ke++ +++++v+ViGg+nSa+D+A+e
   EFC39407.1 150 aeRLSLETTVNSIEPvenKDSEYKVEFEKNgqKFTriYKGVIINNGHHWCRRMPSYEGQSKftgLLIHSKDYKEPSIFKDKRVLVIGGGNSACDVAVE 247
                  4447788999888875436788****99975533311467*******************98766789******************************* PP

  Pyr_redox_3 183 lvrkgaeVtvvtrg 196
                   +r+g+e ++ +r+
   EFC39407.1 248 AARYGKESHISIRR 261
                  ******99988876 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00036
  Pyr_redox_3 211 kpdienrleelvkeekikvlfnaevkeikekeeeykvktedgkkvevkddvvlatGykpdlsflkkslfeldedgrpvl 289
                   p+i+++l +++k +  +++ + ++k  k      kv++++g++ ++ d +v +tGy  ++ +l++ + ++ e g+p+l
   EFC39407.1 321 HPTINSELLQYLKLG--EIHPHGDIKCFK---GGNKVEFKNGEE-REFDVIVCCTGYFTSVPLLDNFVTKT-EFGYPKL 392
                  688888888888777..455554466665...456899***987.444555555**********9666655.8888876 PP

>> K_oxygenase  L-lysine 6-monooxygenase (NADPH-requiring)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0      0.58   1.2e+03     188     203 ..      57      72 ..      40      81 .. 0.76
   2 !   39.7   0.0   1.6e-13   3.2e-10      96     221 ..     138     259 ..     126     267 .. 0.87
   3 ?    3.3   0.0     0.018        37     297     340 ..     328     371 ..     316     373 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.58
  K_oxygenase 188 llakkriaVvGsGqSa 203
                  +++++++++vG+G S+
   EFC39407.1  57 EKTENKFLIVGCGFSG 72 
                  7789999******998 PP

  == domain 2  score: 39.7 bits;  conditional E-value: 1.6e-13
  K_oxygenase  96 kefedYlrWvasqleeqvrfgeeveevepdeeeeeelltveskdaegeeeelearnlvlgvGte..pkiPevleklegkervvHsseylerkeellak 191
                  + f+dY++    ++ e+++ +++v+++ep+e+++ + ++ve  +++g++ ++  + +++  G +  + +P+   + + +  ++Hs++y e      + 
   EFC39407.1 138 EYFHDYCKH--YRIAERLSLETTVNSIEPVENKD-SEYKVEF-EKNGQKFTRIYKGVIINNGHHwcRRMPSYEGQSKFTGLLIHSKDYKEPS--IFKD 229
                  5699***96..578899999***********875.699***9.689****************653389****9999999*********9987..9*** PP

  K_oxygenase 192 kriaVvGsGqSaaeifedllrrqkkvelkl 221
                  kr++V+G+G Sa +++ +++r  k++++++
   EFC39407.1 230 KRVLVIGGGNSACDVAVEAARYGKESHISI 259
                  *******************99988777764 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.018
  K_oxygenase 297 llpnrevesaeaegkgeveltlrneesgeeetlevdavvlATGY 340
                  ll++ ++ +++ +g+ ++    ++ e ++ e+ e+d++v++TGY
   EFC39407.1 328 LLQYLKLGEIHPHGDIKCFKGGNKVEFKNGEEREFDVIVCCTGY 371
                  56666666666666544444555666678899************ PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.7   0.0   6.6e-13   1.3e-09       2     170 ..      62     257 ..      61     273 .. 0.69
   2 ?    3.6   0.0     0.016        31     207     244 ..     344     378 ..     326     391 .. 0.77

  Alignments for each domain:
  == domain 1  score: 37.7 bits;  conditional E-value: 6.6e-13
                  SEEEE--SHHHHHHHHHHHHHTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHH.................................HHHHCHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................................xxxxxxxxx RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaqagakvtlvelegtclnggcllskallgvaedaeias.................................evvkklnqg 66 
                  + +++G G+ Gl  + tl ++g+   +v +++++ +g  ++     gv e ++i+s                                 +    ++  
   EFC39407.1  62 KFLIVGCGFSGLGSSATLTRYGIPFDIV-DTNNVIGGNWSV-----GVYESTHIISsrlttefkdypmpssfpqfpscrqmmeyfhdycK---HYRIA 150
                  568*************************.666666664443.....3333333333344555667888889*999999999988885552...33333 PP

                  CCCCHCCTCEEEE...ESCEEEEETEEECTCEEEEEESEEEE---E.EE-BC.TCTTC.TTBEECCSECHHHHHHCCSS-T.SEEEEES-SHHHHHHH CS
                  xxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxx RF
  Pyr_redox_2  67 ielllgeevvkid...pgkkkvklekkkegdeekiaydklvlAtGs.sprdl.gipGvaenvgklvrtldsaealklkllp.krivvvGgGyiGvElA 158
                   +l l+++v +i+   ++  ++k+e +k+g++++  y+ +++  G  + r++   +G  + +g l   ++s+++ +    + kr++v+GgG+ ++++A
   EFC39407.1 151 ERLSLETTVNSIEpveNKDSEYKVEFEKNGQKFTRIYKGVIINNGHhWCRRMpSYEGQSKFTGLL---IHSKDYKEPSIFKdKRVLVIGGGNSACDVA 245
                  333333334444432244466777667779999999*********64555555999**7887777...3333333333333368************** PP

                  HHHHHHT-EEEE CS
                  xxxxxxxxxxxx RF
  Pyr_redox_2 159 aalaklgkevtl 170
                   ++a++gke ++
   EFC39407.1 246 VEAARYGKESHI 257
                  ********9775 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.016
                  EEEEETTEEEEEEETTSCEEEESEEEE-S-EEES-HHC CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 207 keidgngeklevvledgeeidadlvvvavGvrpstell 244
                  k ++g ++   v+ ++gee + d +v ++G+  s +ll
   EFC39407.1 344 KCFKGGNK---VEFKNGEEREFDVIVCCTGYFTSVPLL 378
                  44555554...999999999999999999998888887 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.0    0.0077        15       2      33 ..      63      94 ..      62      99 .. 0.87
   2 ?   -1.5   0.0       1.9   3.9e+03      57      78 ..     153     176 ..     135     180 .. 0.69
   3 !   20.1   0.0   3.4e-07   0.00068       1      31 [.     231     261 ..     231     270 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0077
                EEEECSSHHHHHHHHHHHHTTSEEEEEESSSS CS
   Pyr_redox  2 vvvvGgGyiglElAgalaelgkkVtvversdk 33
                 ++vG G++gl   ++l+++g    +v+ ++ 
  EFC39407.1 63 FLIVGCGFSGLGSSATLTRYGIPFDIVDTNNV 94
                68*******************99988887765 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.9
                 EECSEEEEEEEEETTS..EEEEEE CS
   Pyr_redox  57 vllntkveeiegsedg..vesvkl 78 
                 + l+t+v++ie  e++   ++v++
  EFC39407.1 153 LSLETTVNSIEPVENKdsEYKVEF 176
                 568899999995444422444555 PP

  == domain 3  score: 20.1 bits;  conditional E-value: 3.4e-07
                 EEEEECSSHHHHHHHHHHHHTTSEEEEEESS CS
   Pyr_redox   1 kvvvvGgGyiglElAgalaelgkkVtvvers 31 
                 +v+v+GgG++++++A ++a++gk+ ++  r+
  EFC39407.1 231 RVLVIGGGNSACDVAVEAARYGKESHISIRR 261
                 79**********************9987666 PP

>> NAD_binding_8  NAD(P)-binding Rossmann-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.0     8e-08   0.00016       1      38 [.      65     102 ..      65     140 .. 0.87
   2 ?    2.1   0.2      0.12   2.3e+02       1      23 [.     234     256 ..     234     259 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 8e-08
                    EE--SHHHHHHHHHHHCCTEEEEEE-SSSSSSGGG-EE CS
  NAD_binding_8   1 IvGaGlsGlvaAylLakagfdvlllekrdrlGGraasy 38 
                    IvG G+sGl   ++L+++g+  +++++++ +GG+++  
     EFC39407.1  65 IVGCGFSGLGSSATLTRYGIPFDIVDTNNVIGGNWSVG 102
                    9*********************************9855 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.12
                    EE--SHHHHHHHHHHHCCTEEEE CS
  NAD_binding_8   1 IvGaGlsGlvaAylLakagfdvl 23 
                    ++G+G s++  A ++a++g++ +
     EFC39407.1 234 VIGGGNSACDVAVEAARYGKESH 256
                    8*****************99765 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0016       3.2       2      77 ..      63     149 ..      62     198 .. 0.71
   2 ?    1.3   0.2      0.11   2.1e+02       1      22 [.     231     252 ..     231     259 .. 0.85
   3 ?    3.3   0.0     0.026        52     179     207 ..     349     378 ..     333     409 .. 0.73

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0016
                 EEEECTSHHHHHHHHHHHHTT..EEEEESSSSTT...SSGGGSSEEEEESSS......STHHSTH..HHHHHHHHHHHHHHHHHHHHSS CS
         DAO   2 vviiGGGiiGlstAyeLarrg..Vtllekgdiag...sgaSgrnsgllhsgl......rylpeas..elarlslealeelreleeelgi 77 
                  +i+G G  Gl+    L+r g    +++ ++ +g   s     ++ +++s l      +  p  s   +++ +++ +e++++++++++i
  EFC39407.1  63 FLIVGCGFSGLGSSATLTRYGipFDIVDTNNVIGgnwSVGVYESTHIISSRLttefkdY--PMPSsfPQFPSCRQMMEYFHDYCKHYRI 149
                 68****************999999******99994421222334444444447666532..3222455559999999999999998665 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.11
                 EEEEECTSHHHHHHHHHHHHTT CS
         DAO   1 dvviiGGGiiGlstAyeLarrg 22 
                 +v++iGGG   + +A e+ar g
  EFC39407.1 231 RVLVIGGGNSACDVAVEAARYG 252
                 59****************9976 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.026
                 EEEEE..EECTEEEEEEEEEEE--GGGHH..HH CS
         DAO 179 vwgve..rttpgendaadavVnaaGawsd..ll 207
                 + +ve  +   ge++++d +V ++G +++  ll
  EFC39407.1 349 GNKVEfkN---GEEREFDVIVCCTGYFTSvpLL 378
                 45563333...777678**********987544 PP

>> NAD_binding_9  FAD-NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6   0.1    0.0035         7       2      45 ..      65     102 ..      64     197 .. 0.77
   2 ?   -1.6   0.0       1.2   2.3e+03       2      25 ..     234     256 ..     233     273 .. 0.62
   3 ?    2.4   0.0     0.069   1.4e+02     126     155 ..     342     371 ..     337     372 .. 0.89

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.0035
  NAD_binding_9   2 ivGaGprGlavlerLlarakkkspleitlfdpsepgagrvwrtd 45 
                    ivG+G++Gl   + L +       +  +++d ++   g+ w+  
     EFC39407.1  65 IVGCGFSGLGSSATLTRY-----GIPFDIVDTNNVI-GGNWSVG 102
                    99******9999999988.....4777778887776.6666655 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.2
  NAD_binding_9   2 ivGaGprGlavlerLlarakkksp 25 
                    ++G+G ++  v+ + ++   k+s+
     EFC39407.1 234 VIGGGNSACDVAVEAARYG-KESH 256
                    6777777777776666553.3333 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.069
  NAD_binding_9 126 dleeradgqavlladgaslaadaVvLAlGh 155
                    d+++ ++g +v  ++g++ ++d +v ++G 
     EFC39407.1 342 DIKCFKGGNKVEFKNGEEREFDVIVCCTGY 371
                    567778888999*****************6 PP

>> FAD_oxidored  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.0    0.0038       7.5       3      43 ..      64     104 ..      63     158 .. 0.92
   2 ?    6.2   0.1    0.0028       5.6       2      26 ..     232     256 ..     231     263 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0038
  FAD_oxidored   3 vVvGGgpaGvaAAiaAaraGakvlLveergvlGGlltsglv 43 
                   ++vG g +G+    +  r G    +v++++v+GG+ + g+ 
    EFC39407.1  64 LIVGCGFSGLGSSATLTRYGIPFDIVDTNNVIGGNWSVGVY 104
                   79**********************************99875 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0028
  FAD_oxidored   2 vvVvGGgpaGvaAAiaAaraGakvl 26 
                   v+V+GGg + +  A+ Aar G++  
    EFC39407.1 232 VLVIGGGNSACDVAVEAARYGKESH 256
                   89*******************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.50
# Mc/sec: 3027.89
//
Query:       EFC39408.1  [L=902]
Description: SNc domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.4e-47  158.5  24.2    3.8e-12   46.6   0.2    6.5  5  SNase          Staphylococcal nuclease homologue
    2.6e-18   66.2   0.0    5.2e-18   65.2   0.0    1.5  1  TUDOR          Tudor domain
    6.8e-06   25.5   0.9    1.4e-05   24.5   0.0    2.0  2  SMN            Survival motor neuron protein (SMN)
    0.00014   22.1   1.3    0.00034   20.8   0.2    2.3  2  Kinesin_assoc  Kinesin-associated
     0.0047   17.4   0.0       0.07   13.6   0.0    3.0  3  Agenet         Agenet domain
  ------ inclusion threshold ------
      0.053   13.7   0.1         11    6.3   0.0    3.1  3  SH3_11         Retroviral integrase C-terminal SH3 domain
      0.093   12.7   0.0       0.25   11.3   0.0    1.7  1  SAWADEE        SAWADEE domain


Domain annotation for each model (and alignments):
>> SNase  Staphylococcal nuclease homologue
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.6   0.2   1.5e-15   3.8e-12       2     108 .]      30     134 ..      29     134 .. 0.90
   2 !   30.1   1.7     2e-10   5.2e-07       3     107 ..     185     316 ..     184     317 .. 0.84
   3 !   37.5   2.3     1e-12   2.7e-09      10     105 ..     374     481 ..     356     483 .. 0.85
   4 !   38.3   0.0   5.6e-13   1.4e-09       2     107 ..     540     641 ..     539     642 .. 0.88
   5 !   14.2   0.2   1.7e-05     0.044      28     107 ..     808     890 ..     797     891 .. 0.85

  Alignments for each domain:
  == domain 1  score: 46.6 bits;  conditional E-value: 1.5e-15
                 EEETTEE-STSSBTTTTTSTTHHHHHHHHHHHHHHCSSEEEEE-SSBSTTSEEEEEEEETTEEHHHHHHHTTSSEE---BTTSTTTHHHHHHHHHHHHH CS
       SNase   2 vrLvgidaPetakpkktvqpfgkeAkeflkklvlqkkvvvleldkkkDkygrllayvylnkknineeLvkeGlArvyevyekneekkkellkaeeeAkk 100
                 + L+++ aP+   +  + +p++ eA+efl+k++++k+ +  ++ +   + g   a+++l+++nine  v++G  +v  + + +++++k+l +++++A +
  EFC39408.1  30 LILADVKAPRLGTKDGEDEPWAFEAREFLRKKLIGKTIRFRVDYT-VKETGMNYATIFLDDENINESVVEAGWGKVKDIKN-QSDDYKKLIALQKAAEE 126
                 5699********9999******************88777776666.67889999*********************777665.789************** PP

                 TT-GGGCT CS
       SNase 101 krkglWse 108
                 ++ g Ws+
  EFC39408.1 127 QKIGVWSN 134
                 ******96 PP

  == domain 2  score: 30.1 bits;  conditional E-value: 2e-10
                 EETTEE-STSSBTTT....TTSTTHHHHHHHHHHHHHHCSSEEEEE-S................SBSTTSEEEEEEEET.......TEEHHHHHHHTTS CS
       SNase   3 rLvgidaPetakpkk....tvqpfgkeAkeflkklvlqkkvvvleldk................kkDkygrllayvyln.......kknineeLvkeGl 74 
                  L g+ +P t k k+     +qpf keAk  ++ ++l+++v+vl +++                +k k  +l ++++++           +eeL+  G+
  EFC39408.1 185 NLTGVYCPSTTKGKEtqqkVAQPFSKEAKTHTEVRLLNRDVTVLFEGIdtpkkdkskdgkdakeQKEKTSNLHGSIIISvdensdkPFTYQEELLMIGY 283
                 588999999998888888899********************99877666664445556555555556677888999988999997666789******** PP

                 SEE---BTTSTTTHHHHHHHHHHHHHTT-GGGC CS
       SNase  75 ArvyevyekneekkkellkaeeeAkkkrkglWs 107
                  +v e   +++++ +++++ae++Ak++rk+lW 
  EFC39408.1 284 VSVDERSAPKSKYAPRFRSAEQKAKNERKNLWV 316
                 **9999999***********************6 PP

  == domain 3  score: 37.5 bits;  conditional E-value: 1e-12
                 STSSBTTT......TTSTTHHHHHHHHHHHHHHCSSEEEEE-S....SBSTTSEEEEEEEETTEEHHHHHHHTTSSEE--.-BTT.STTTHHHHHHHHH CS
       SNase  10 Petakpkk......tvqpfgkeAkeflkklvlqkkvvvleldk....kkDkygrllayvylnkknineeLvkeGlArvye.vyek.neekkkellkaee 96 
                 Pe+++  k      + ++++ eA+e l+++v +k+ +v+++ +     + k+ r   +v +nkk+++ eLv+eG+A v++   ++ ++   + l  ae+
  EFC39408.1 374 PEKKEASKqaeqkpESEQWAWEARELLRSKVAGKEIQVEVDYRrelgTEKKELRRFCTVLVNKKSVAVELVREGYAEVMKlKADEeRSSAFDSLILAEN 472
                 4444444466666699******************9999988777888888999**************************963333589999******** PP

                 HHHHTT-GG CS
       SNase  97 eAkkkrkgl 105
                 eA k++kgl
  EFC39408.1 473 EAIKRQKGL 481
                 *******98 PP

  == domain 4  score: 38.3 bits;  conditional E-value: 5.6e-13
                 EEETTEE-STSSBTTTTTSTTHHHHHHHHHHHHHHCSSEEEEE-SSBSTTSEEEEEEEETTEEHHHHHHHTTSSEE---BTTSTTTHHHHHHHHHHHHH CS
       SNase   2 vrLvgidaPetakpkktvqpfgkeAkeflkklvlqkkvvvleldkkkDkygrllayvylnkknineeLvkeGlArvyevyekneekkkellkaeeeAkk 100
                 ++L+gi  P + kp    ++ ++eAk+ +   ++ ++v+++ + +  Dk   l +++ +n+kn  ++L+++GlA  ++ y k+ +  +el +ae +Akk
  EFC39408.1 540 FSLAGIAIPSSDKPLG--KDLAEEAKQLTLISTSCRDVELVLEAE-VDKASSLTGQMLINGKNYTNTLLEAGLAI-VQPYAKRLKIFEELNEAEGKAKK 634
                 7899******996666..99*******998888877776555444.6****************************.56688899*************** PP

                 TT-GGGC CS
       SNase 101 krkglWs 107
                 ++kg W+
  EFC39408.1 635 AKKGVWK 641
                 ******7 PP

  == domain 5  score: 14.2 bits;  conditional E-value: 1.7e-05
                 HHHHHHHHHCSSEEEEE-SSBSTTSEEEEEEEET...TEEHHHHHHHTTSSEE--..-BTTSTTTHHHHHHHHHHHHHTT-GGGC CS
       SNase  28 eflkklvlqkkvvvleldkkkDkygrllayvyln...kknineeLvkeGlArvye..vyekneekkkellkaeeeAkkkrkglWs 107
                  fl++ +++ + +++++ +  D   +++  v      + n+n+++++ Gl ++ +    ++ +   k +l+ ++ A ++r++lW+
  EFC39408.1 808 TFLRETLMEGEWQLTVEYS--DAGVNYVTLVQNGakqEDNLNKQMIRSGLVFADKklLLSEFKSVAKSYLEEQDFAISRRLNLWE 890
                 6888888888888888888..888888888887788899***********98877645566888999*****************6 PP

>> TUDOR  Tudor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.2   0.0     2e-21   5.2e-18       5     121 ..     678     794 ..     674     795 .. 0.91

  Alignments for each domain:
  == domain 1  score: 65.2 bits;  conditional E-value: 2e-21
                 GEEEEEEEEEEETTEEEEEEGGHHHHHHHHHHHHHHHHTSSCCTCSSS--TT-EEEEEETTTTEEEEEEEEEECTTTEEEEEETTTSBEEEEEGGGEEE CS
       TUDOR   5 ktievvvsaiespskfyiqpkeqskkleklteelqeyyaskkkaellapavgegcvavfsedgkwyRAkiteslddqkveVlfiDyGntetvpvsdlre 103
                 kt  + v+++e+p +fy+q ++  +kl ++ + + e   ++ +  l + +vg  c+a+f+ed+ wyRAk+  s+++ ++ Vl+ D+Gn+e+v++s l+ 
  EFC39408.1 678 KTQTIRVTDFEDPITFYYQGSDVVEKLKTVEKLIAELNVAQLE-ALASATVGSVCLAQFTEDNSWYRAKV-ISVNNANAVVLYSDFGNSEEVAISTLKT 774
                 677889************9999999999888888887666666.7899**********************.**************************** PP

                 --..GGGCSS-BSSEEEEET CS
       TUDOR 104 lp..seleelppqaikcrLa 121
                 +p   +l+++p +a k+rLa
  EFC39408.1 775 IPagNQLLTIPECAQKARLA 794
                 **88899999******9996 PP

>> SMN  Survival motor neuron protein (SMN)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       1.9   4.8e+03     106     138 ..     350     382 ..     338     399 .. 0.51
   2 !   24.5   0.0   5.6e-09   1.4e-05      69     123 ..     725     777 ..     708     791 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 1.9
         SMN 106 gygneeeqnladllteasdededalkeanvnet 138
                 + g+ee+ +l++++t++     ++ ++++  ++
  EFC39408.1 350 NDGQEEKISLSNIRTKKFISYTKKPEKKEASKQ 382
                 456666666776666654322222222222222 PP

  == domain 2  score: 24.5 bits;  conditional E-value: 5.6e-09
         SMN  69 wkvgdscnavwsedgnvypatiasidakkgtcvvvytgygneeeqnladllteas 123
                   vg  c a ++ed   y a + s+++     vv+y+++gn+ee +++ l+t ++
  EFC39408.1 725 ATVGSVCLAQFTEDNSWYRAKVISVNNA--NAVVLYSDFGNSEEVAISTLKTIPA 777
                 579*********************9975..689***************9998655 PP

>> Kinesin_assoc  Kinesin-associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.6   4.2e+03      10      46 ..     442     479 ..     434     539 .. 0.57
   2 !   20.8   0.2   1.3e-07   0.00034      39     119 ..     639     720 ..     591     727 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.6
  Kinesin_assoc  10 klvrelkeeverlk.dlllaqglediidseaeplkegl 46 
                     lvre  +ev +lk d  ++ + + +i +e+e++k+++
     EFC39408.1 442 ELVREGYAEVMKLKaDEERSSAFDSLILAENEAIKRQK 479
                    57788888888887334455555555554444444332 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 1.3e-07
  Kinesin_assoc  39 aeplkeglvll.aseraknlsavtaavaglspssslsalssraesvssleerivfspaseeaierlketekiiaelnetWee 119
                    + +l++ +v + + +++++ ++ ++++  +++ s + + ++++  v++ e+ i+f     + +e+lk  ek+iaeln +  e
     EFC39408.1 639 VWKLEDHTVAFpERKKREQPEQEQKSKPVAQSFSVSHSRKTQTIRVTDFEDPITFYYQGSDVVEKLKTVEKLIAELNVAQLE 720
                    3333333333332233333333333333333334344444455699*******************************76655 PP

>> Agenet  Agenet domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0         5   1.3e+04      23      36 ..     306     319 ..     299     325 .. 0.70
   2 ?   -1.9   0.0       1.8   4.7e+03      18      57 ..     332     363 ..     331     365 .. 0.69
   3 !   13.6   0.0   2.7e-05      0.07      15      40 ..     739     765 ..     735     779 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 5
      Agenet  23 lkvkegdkylVeYd 36 
                 + ++e++ ++V Y+
  EFC39408.1 306 KAKNERKNLWVDYE 319
                 44567788888886 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 1.8
      Agenet  18 frAtilkvkegdkylVeYddlddddgskpleEwvdasdiR 57 
                 f+A +l+v +gd++++  +d       +  eE++++s iR
  EFC39408.1 332 FTARVLEVLSGDTLKIVKND-------G-QEEKISLSNIR 363
                 67888888888888776555.......2.25677777777 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 2.7e-05
      Agenet  15 GaWfrAtilkvkegdkylVeYdd..ldd 40 
                  +W+rA++++v ++  ++V Y d   ++
  EFC39408.1 739 NSWYRAKVISV-NNANAVVLYSDfgNSE 765
                 58*********.99*********43333 PP

>> SH3_11  Retroviral integrase C-terminal SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.78     2e+03       8      28 ..     197     217 ..     192     230 .. 0.75
   2 ?    3.0   0.0     0.045   1.2e+02      30      58 ..     335     363 ..     331     367 .. 0.91
   3 ?    6.3   0.0    0.0042        11      29      59 ..     744     774 ..     738     779 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.78
      SH3_11   8 Gqlvqervarpaslrprwhkp 28 
                 G+  q++va+p s   + h  
  EFC39408.1 197 GKETQQKVAQPFSKEAKTHTE 217
                 77789******9988877754 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.045
      SH3_11  30 tvlevlnprtvvildhlGnnrtvsidnlk 58 
                  vlevl   t+ i+   G +  +s+ n++
  EFC39408.1 335 RVLEVLSGDTLKIVKNDGQEEKISLSNIR 363
                 69***********************9987 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0042
      SH3_11  29 stvlevlnprtvvildhlGnnrtvsidnlkp 59 
                 + v+ v n  +vv+   +Gn   v+i  lk 
  EFC39408.1 744 AKVISVNNANAVVLYSDFGNSEEVAISTLKT 774
                 46999***********************995 PP

>> SAWADEE  SAWADEE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   9.9e-05      0.25       9      44 ..     735     771 ..     732     790 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 9.9e-05
                 -TTTS-EEEEEEEEEEEE-.EEEETTC-GGGEEEEEH CS
     SAWADEE   9 sskDeaWYdvrvflekral.rvkfegfgeeedewvnv 44 
                  ++D++WY ++v+  ++a  +v +++fg+ e+ +++ 
  EFC39408.1 735 FTEDNSWYRAKVISVNNANaVVLYSDFGNSEEVAIST 771
                 579********97665555499*********998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (902 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1027  (0.0572815); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.79u 0.32s 00:00:01.11 Elapsed: 00:00:00.53
# Mc/sec: 5131.55
//
Query:       EFC39409.1  [L=531]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-23   81.9   0.3    7.8e-23   80.7   0.3    1.7  1  Rtt106    Histone chaperone Rttp106-like
    2.6e-22   79.0   1.8    2.4e-17   63.1   0.2    2.8  2  POB3_N    POB3-like N-terminal PH domain
      3e-17   62.3   0.0    1.2e-16   60.3   0.0    2.1  1  SSrecog   Structure-specific recognition protein (SSRP1)


Domain annotation for each model (and alignments):
>> Rtt106  Histone chaperone Rttp106-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.7   0.3   1.3e-26   7.8e-23       2      87 ..     362     447 ..     361     449 .. 0.97

  Alignments for each domain:
  == domain 1  score: 80.7 bits;  conditional E-value: 1.3e-26
      Rtt106   2 gVkasrkakeGlLyflekgllfgfkkPllfiplediesvsfeRvsvtsrtfdlvvelkk.eeveFsmidqeelegidefvkskgiki 87 
                 + k+s+ka+eG+L+flek+++f ++kP+++i++++i+ ++f R+s+ +r fdl++ lk+ ++++F +idq+e e + ef+ksk++k 
  EFC39409.1 362 ALKCSLKANEGQLFFLEKSVFF-LHKPVIYIRHDEIKLIKFLRASSGNRFFDLSIILKNgKSHTFLNIDQNESELLSEFLKSKDLKT 447
                 579*******************.**********************************999************************997 PP

>> POB3_N  POB3-like N-terminal PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.1   0.2   4.1e-21   2.4e-17       2      85 ..       4      91 ..       3      97 .. 0.91
   2 !   14.1   0.1   7.8e-06     0.047      34      86 ..     388     443 ..     384     449 .. 0.90

  Alignments for each domain:
  == domain 1  score: 63.1 bits;  conditional E-value: 4.1e-21
      POB3_N  2 efeniylelsgdsGklrls...esglgwknsktgkv.vqikasdissaqWvrvargyqLrillkdgkvvrfdGFkeedfdkLskllkk 85
                ef++i+l++s ++G++++    e++++wk+ ++++    +k+s+iss++W+ ++rgy+Lr++  d+++v++ GFke+d+++L++++ +
  EFC39409.1  4 EFSHIFLGRSFTQGSIIVDaknEEMFVWKSVGNESIiSAVKKSEISSIDWLYTPRGYELRLWKADDDFVSYLGFKEADYEQLESQIVQ 91
                8***************775445899*********874689**********************99*******************99876 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 7.8e-06
      POB3_N  34 vvqikasdissaqWvrva...rgyqLrillkdgkvvrfdGFkeedfdkLskllkkn 86 
                 v+ i++++i+ ++++r++   r + L+i lk+gk ++f   ++++ + Ls++lk++
  EFC39409.1 388 VIYIRHDEIKLIKFLRASsgnRFFDLSIILKNGKSHTFLNIDQNESELLSEFLKSK 443
                 678999**********98777889*****************************975 PP

>> SSrecog  Structure-specific recognition protein (SSRP1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.3   0.0     2e-20   1.2e-16       1      69 []     109     179 ..     109     179 .. 0.96

  Alignments for each domain:
  == domain 1  score: 60.3 bits;  conditional E-value: 2e-20
     SSrecog   1 GwNwGkaefegselvfqvdnkpafeipls.evsnc.nlagknEvaleFhqdddaaenedqLvEmRfyvPgt 69 
                 G+NwGk  ++gs++++ +++k++f i+l+ ++ nc ++++++E+ leF +d+++++n+ qL+E+Rf++P+t
  EFC39409.1 109 GVNWGKPVIKGSHMMMYFEDKELFSISLAdDIKNCqKIPKNSELLLEFRDDEHTDKNSIQLTEIRFVCPET 179
                 9**************************97369999889*******************************86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (531 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1160  (0.0646996); expected 358.6 (0.02)
Passed bias filter:                      500  (0.0278878); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.31s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 3069.87
//
Query:       EFC39410.1  [L=228]
Description: differentiation-specific calcium binding protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
      2e-20   70.8   5.7    4.4e-06   25.8   0.1    4.1  4  EF-hand_1  EF hand
    2.4e-16   59.9   1.6      2e-10   40.9   0.3    2.5  2  EF-hand_7  EF-hand domain pair
    2.7e-16   58.1   4.1    0.00033   20.3   0.1    4.0  4  EF-hand_6  EF-hand domain
    1.4e-13   49.6   8.4      8e-05   22.0   0.0    4.1  4  EF-hand_5  EF hand
    7.6e-13   48.1   7.1    5.2e-06   26.2   0.1    3.6  3  EF-hand_8  EF-hand domain pair
      2e-05   24.5   2.9       0.39   10.7   0.1    3.3  3  EF-hand_4  Cytoskeletal-regulatory complex EF hand
  ------ inclusion threshold ------
       0.14   12.5   0.1        5.2    7.5   0.0    2.6  2  EF-hand_9  EF-hand domain


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.29   7.5e+02      12      28 ..      71      87 ..      70      88 .. 0.85
   2 !   25.8   0.1   1.7e-09   4.4e-06       2      27 ..     100     125 ..      99     127 .. 0.91
   3 !   19.7   0.2   1.6e-07   0.00042       2      28 ..     136     162 ..     135     163 .. 0.91
   4 !   24.9   0.2   3.5e-09   8.9e-06       4      26 ..     189     211 ..     186     213 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.29
                TSSSEEEHHHHHHHHHH CS
   EF-hand_1 12 DgdGkIdfeEfkellkk 28
                D  G++++ +f +++ k
  EFC39410.1 71 DSKGRLSKPQFEQVVVK 87
                889********998865 PP

  == domain 2  score: 25.8 bits;  conditional E-value: 1.7e-09
                 HHHHHHHHTTTSSSEEEHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellk 27 
                 +++iF++fD D++G++df E+ + l+
  EFC39410.1 100 IDKIFDVFDADKSGYVDFVELATGLS 125
                 79*******************98775 PP

  == domain 3  score: 19.7 bits;  conditional E-value: 1.6e-07
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 lk + +++D ++dG+++++E+++++k+
  EFC39410.1 136 LKFVYNLIDINNDGTVEKNELLSFFKR 162
                 678899******************997 PP

  == domain 4  score: 24.9 bits;  conditional E-value: 3.5e-09
                 HHHHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1   4 eiFrefDkDgdGkIdfeEfkell 26 
                  +F+ +D Dg+G Id+eEf+ ++
  EFC39410.1 189 VAFDRMDLDGSGAIDYEEFMVAV 211
                 69*****************9987 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.1   1.2e-06    0.0031      35      67 ..      70     121 ..      45     125 .. 0.67
   2 !   40.9   0.3   7.9e-14     2e-10       2      70 ..     134     211 ..     133     212 .. 0.90

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 1.2e-06
   EF-hand_7  35 a...................gegsklsdeelellfkefDtdkdGvisfdEFl 67 
                                     g  s+++  +++++f+ fD dk+G+++f E+ 
  EFC39410.1  70 SdskgrlskpqfeqvvvktlGSHSESDLVSIDKIFDVFDADKSGYVDFVELA 121
                 344455555555555555446666656678******************9976 PP

  == domain 2  score: 40.9 bits;  conditional E-value: 7.9e-14
   EF-hand_7   2 eklkeaFkelDtdgdgyldkeellrllrkifqga.........gegsklsdeelellfkefDtdkdGvisfdEFlkly 70 
                 e lk +++++D ++dg ++k+ell+++++++ g          +e  ++ +++l   f+ +D+d++G i+++EF+ ++
  EFC39410.1 134 ELLKFVYNLIDINNDGTVEKNELLSFFKRFYVGQakmngyrlsSERWHTLEKHLSVAFDRMDLDGSGAIDYEEFMVAV 211
                 668999*************************999**99988886666667799*********************9765 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.88   2.3e+03      12      26 ..      71      85 ..      66      90 .. 0.81
   2 !   20.3   0.1   1.3e-07   0.00033       2      27 ..     100     125 ..      99     128 .. 0.90
   3 !   17.3   0.1   1.2e-06    0.0031       2      28 ..     136     162 ..     135     172 .. 0.88
   4 !   19.1   0.0   3.3e-07   0.00086       5      26 ..     190     211 ..     186     219 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.88
   EF-hand_6 12 dgdGkidaeElrkal 26
                d  G +++ ++ ++ 
  EFC39410.1 71 DSKGRLSKPQFEQVV 85
                77899***9999865 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 1.3e-07
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalr 27 
                 ++++F+ fD d++G++d+ El   l+
  EFC39410.1 100 IDKIFDVFDADKSGYVDFVELATGLS 125
                 679******************88776 PP

  == domain 3  score: 17.3 bits;  conditional E-value: 1.2e-06
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalrk 28 
                 l+ +++l+D ++dG++ ++El +++++
  EFC39410.1 136 LKFVYNLIDINNDGTVEKNELLSFFKR 162
                 67799******************9985 PP

  == domain 4  score: 19.1 bits;  conditional E-value: 3.3e-07
   EF-hand_6   5 aFklfDkdgdGkidaeElrkal 26 
                 aF+ +D dg+G id+eE++ a 
  EFC39410.1 190 AFDRMDLDGSGAIDYEEFMVAV 211
                 8*****************8765 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.3   1.9e-06    0.0048       1      23 [.     100     122 ..     100     125 .. 0.89
   2 ?   -2.7   0.0         2   5.1e+03      17      25 .]     131     139 ..     131     139 .. 0.82
   3 !   14.2   0.1   9.1e-06     0.023       7      24 ..     142     159 ..     141     163 .. 0.87
   4 !   22.0   0.0   3.1e-08     8e-05       3      22 ..     190     208 ..     189     211 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.9e-06
                 HHHHHHHH-SS-SSCE-HHHHHH CS
   EF-hand_5   1 lkdtFqaiDlNgDGkIskeELkt 23 
                 +++ F+ +D++++G++++ EL t
  EFC39410.1 100 IDKIFDVFDADKSGYVDFVELAT 122
                 6789**************99977 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2
                 -HHHHHHHH CS
   EF-hand_5  17 skeELktlv 25 
                 +k EL ++v
  EFC39410.1 131 DKKELLKFV 139
                 789*99886 PP

  == domain 3  score: 14.2 bits;  conditional E-value: 9.1e-06
                 HH-SS-SSCE-HHHHHHH CS
   EF-hand_5   7 aiDlNgDGkIskeELktl 24 
                  iD N+DG++ k EL  +
  EFC39410.1 142 LIDINNDGTVEKNELLSF 159
                 69*************764 PP

  == domain 4  score: 22.0 bits;  conditional E-value: 3.1e-08
                 HHHHHH-SS-SSCE-HHHHH CS
   EF-hand_5   3 dtFqaiDlNgDGkIskeELk 22 
                 + F+++Dl+g+G I+ eE++
  EFC39410.1 190 A-FDRMDLDGSGAIDYEEFM 208
                 4.*****************6 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.6   1.3e-05     0.032      28      48 ..     100     120 ..      53     124 .. 0.88
   2 !   10.0   0.1   0.00023      0.59      33      54 ..     141     162 ..     133     162 .. 0.92
   3 !   26.2   0.1     2e-09   5.2e-06      28      54 ..     187     213 ..     180     213 .. 0.89

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.3e-05
   EF-hand_8  28 vdilfrefDtdgdGkisfeEF 48 
                 +d +f+ fD d++G+++f E 
  EFC39410.1 100 IDKIFDVFDADKSGYVDFVEL 120
                 6779*************9875 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00023
   EF-hand_8  33 refDtdgdGkisfeEFcvller 54 
                 +++D+++dG++ ++E + +++r
  EFC39410.1 141 NLIDINNDGTVEKNELLSFFKR 162
                 689**************99986 PP

  == domain 3  score: 26.2 bits;  conditional E-value: 2e-09
   EF-hand_8  28 vdilfrefDtdgdGkisfeEFcvller 54 
                 + + f+++D+dg+G+i++eEF+v +e+
  EFC39410.1 187 LSVAFDRMDLDGSGAIDYEEFMVAVED 213
                 5678*******************9985 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.1    0.0014       3.6      19      66 ..      69     121 ..      52     126 .. 0.64
   2 !    5.4   0.1    0.0069        18      42      65 ..     133     156 ..     126     165 .. 0.84
   3 !   10.7   0.1   0.00015      0.39      42      69 ..     184     211 ..     158     213 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0014
   EF-hand_4  19 lkpednkltgdkvapvlkn...skleed..klekiwdladidedgkldfeefc 66 
                  ++++ +l++ +  +v+ +   s+ e+d   ++ki+d+ d d+ g +df e++
  EFC39410.1  69 SSDSKGRLSKPQFEQVVVKtlgSHSESDlvSIDKIFDVFDADKSGYVDFVELA 121
                 555555566555544432212133333322689****************9986 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0069
   EF-hand_4  42 edklekiwdladidedgkldfeef 65 
                 ++ l+ +++l di++dg+++ +e+
  EFC39410.1 133 KELLKFVYNLIDINNDGTVEKNEL 156
                 5668889***********998886 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00015
   EF-hand_4  42 edklekiwdladidedgkldfeefciam 69 
                 e++l+  +d  d+d  g +d+eef++a+
  EFC39410.1 184 EKHLSVAFDRMDLDGSGAIDYEEFMVAV 211
                 56788899999**************986 PP

>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   0.0     0.002       5.2       1      22 [.     101     122 ..     101     135 .. 0.84
   2 ?    2.0   0.0       0.1   2.6e+02       3      25 ..     139     161 ..     137     173 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.002
   EF-hand_9   1 etvFevcDtqktGrVpvsrlid 22 
                 + +F+v+D +k G V   +l +
  EFC39410.1 101 DKIFDVFDADKSGYVDFVELAT 122
                 579***********98877765 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.1
   EF-hand_9   3 vFevcDtqktGrVpvsrlidyLr 25 
                 v+++ D++  G+V   +l+++ +
  EFC39410.1 139 VYNLIDINNDGTVEKNELLSFFK 161
                 799**********9999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       499  (0.027832); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1350.26
//
Query:       EFC39411.1  [L=624]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
       0.11   12.4   1.1        2.1    8.4   0.1    2.7  2  Ninjurin        Ninjurin
        6.4    7.5   8.0        4.4    8.0   0.9    3.8  3  DUF883          Bacterial protein of unknown function (DUF883


Domain annotation for each model (and alignments):
>> Ninjurin  Ninjurin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.1   0.00023       2.1      37      81 ..      19      63 ..      12      92 .. 0.78
   2 ?    1.5   0.1     0.031   2.8e+02      48      72 ..     246     268 ..     228     300 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00023
    Ninjurin 37 skfyiallvLislSllLqvvvgilliliasklnlekekkerrlnk 81
                 +  ++ l+L ++S++L ++ g++  + +++++l k +++ + n+
  EFC39411.1 19 GNGSMFKLTLAVASIVLIICSGFISAQHQNNKQLAKCHRQLAKNI 63
                5567999******************99888888888887554444 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.031
    Ninjurin  48 slSllLqvvvgilliliasklnlek 72 
                  +S+lL  +  ill l+  k +l++
  EFC39411.1 246 AVSILLLAICSILLCLS--KRSLKN 268
                 47999999999999884..334433 PP

>> DUF883  Bacterial protein of unknown function (DUF883)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.09   8.1e+02      25      53 ..     262     290 ..     261     298 .. 0.78
   2 ?    8.0   0.9   0.00049       4.4       9      56 ..     293     339 ..     285     350 .. 0.84
   3 ?   -0.2   0.6      0.17   1.5e+03      24      68 ..     367     411 ..     345     421 .. 0.61

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.09
      DUF883  25 ageeaeelRerleerlerarerlrdaeea 53 
                 +++++++lR +++  +e+ +e++++ ee+
  EFC39411.1 262 SKRSLKNLRGEIDHLIEDKKETVKKFEEK 290
                 56778889999999999988888887765 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00049
      DUF883   9 slladleellkeaadeageeaeelRerleerlerarerlrdaeeavae 56 
                 +ll+d+++l  ++ de +++++++R+ le++le+ r +++d+e+++ +
  EFC39411.1 293 KLLDDIKNLS-NSLDEKEKQVSDVRAGLEKTLEAERIKISDLEHEISN 339
                 6788888887.5667899************************998776 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.17
      DUF883  24 eageeaeelRerleerlerarerlrdaeeavaerakeaaeaaddy 68 
                 ea e++ +lR+++ee+  +++++ + + ++++  a+e  e  ++y
  EFC39411.1 367 EALEQVLNLRQEIEEEKLALQKKSELLDNSLKITAEELEEMNEQY 411
                 455666666666666666665555555555555554444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (624 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2594  (0.144682); expected 358.6 (0.02)
Passed bias filter:                      657  (0.0366445); expected 358.6 (0.02)
Passed Vit filter:                       113  (0.00630264); expected 17.9 (0.001)
Passed Fwd filter:                        38  (0.00211947); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.21u 0.38s 00:00:01.59 Elapsed: 00:00:00.58
# Mc/sec: 3257.61
//
Query:       EFC39412.1  [L=1405]
Description: SEC7 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      1e-42  145.9   2.7    5.6e-42  143.5   2.7    2.4  1  Sec7      Sec7 domain
    1.6e-20   73.6   7.1    1.6e-20   73.6   7.1    5.5  4  Sec7_N    Guanine nucleotide exchange factor in Golgi transpo
    8.5e-15   54.4   6.7    8.5e-12   44.8   0.3    6.1  5  DUF1981   Domain of unknown function (DUF1981)
    4.7e-14   52.4   6.4    4.7e-14   52.4   6.4    4.3  5  DCB       Dimerisation and cyclophilin-binding domain of Mon2


Domain annotation for each model (and alignments):
>> Sec7  Sec7 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.5   2.7   1.2e-45   5.6e-42       2     183 .]     477     668 ..     476     668 .. 0.91

  Alignments for each domain:
  == domain 1  score: 143.5 bits;  conditional E-value: 1.2e-45
                 HHHHHHHHHHHHH-HHHHHHHHHHCCCCTSS.......HHHHHHHHHHTCCS-HHHHHHHHCSGGHHHHHHHHHHHCTS--TT--HHHHHHHHCCCS-B CS
        Sec7   2 kklleeaaekFnkkpkkgikyliekglleed.......pksiakflketpgldkkklGeylgkekefnkevlkefvdlfdfsglrldeAlRlflssfrl 93 
                 +k+l++++e+Fn++ kkg++y+ + g l+++       + ++a+++ + pg++k+k+Gey++++k  n  vlk+++d+ +fsg+ +++AlR++l  f l
  EFC39412.1 477 RKKLKRGVELFNENLKKGLEYFHQIGRLPDKslditqyELELATLFNTIPGFSKHKVGEYFASPK--NFGVLKKYIDMQSFSGILFEKALRKTLDLFML 573
                 5889************************666455555577788888888****************..******************************** PP

                 -SSHHHHHHHHHHHHHHHHHTTCTC....G-SHHHHHHHHHHHHHHHHHHC-TTS..CCS--HHHHHHCTTTTBTTB---HHHHHHHHHHHHHS-- CS
        Sec7  94 pgEaqkierilekFaekyfeqnpev....fenadavfvLaysiimLntdlhnpqv..kkkmtledFiknnrgindgkdlpeefLeeiYdsIkeeei 183
                 p+E+q+i+r++e+Faeky ++np++    f+n  a+fv+++s++mLnt++hn ++    + t+e+F+++n+ ++  + +++e+ e++Y++++++ei
  EFC39412.1 574 PKESQEINRVIECFAEKYQNDNPDLleteFKNPSACFVFTISVVMLNTEIHNAAMkaLCNSTVESFVERNSLTDA-SCISREYQERVYKNLQDNEI 668
                 **********************95533348*************************443577*********97776.89****************98 PP

>> Sec7_N  Guanine nucleotide exchange factor in Golgi transport N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   2.9      0.44     2e+03      26      93 ..     150     213 ..     108     237 .. 0.67
   2 !   73.6   7.1   3.6e-24   1.6e-20       2     158 .]     264     417 ..     263     417 .. 0.94
   3 ?    1.6   0.8     0.051   2.3e+02      60      98 ..     898     935 ..     868     981 .. 0.72
   4 ?    0.3   0.5      0.13   5.9e+02      64     120 ..    1172    1228 ..    1147    1251 .. 0.71

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 0.44
      Sec7_N  26 lslaersktfsLeLlesvlsnhgdvfrkhpellqllkqklcplLlknlsespsfpvferslrivllLl 93 
                 +++++  + + L+ l+++l+  ++   + ++ll  +k  l  + +    e+++f+v+    +++++++
  EFC39412.1 150 VDISNQDESLQLQFLKTILTAISSCHLSGKSLLIGVKVCLSVHFVSKN-ETNTFSVLK---QVLHMVI 213
                 455666677778888888888888777777776666655544444333.455555555...4444444 PP

  == domain 2  score: 73.6 bits;  conditional E-value: 3.6e-24
      Sec7_N   2 akDaflvfrdLcklinsakskpkflslaersktfsLeLlesvlsnhgdvfrkhpellqllkqklcplLlknlsespsfpvferslrivllLlkkfrseL 100
                 ++Da+lvf+ L   ++ ++ ++    ++e+ k++ ++Ll  v++n g+ + +h+++ + +k+ +c+ Ll nl   +s+++++ +l ++ lL+++f++e+
  EFC39412.1 264 QRDAILVFKYLSASVS-KDFTNG--PFDEKAKLTYIDLLTDVFKNCGRKLLSHQRVFEQVKSIVCQTLLINLVHCKSTQIVLSALGLYQLLMENFLAEM 359
                 58************77.553344..89*********************************************9************************** PP

      Sec7_N 101 ktEievflsllilillesdsslwqrvlaLeilrrlcsdpqllvelylnYDcdeeaknv 158
                 + Ei +++  li+++ +++ s   + l+L +l+++ s+ +l++ ly+n+Dc+ e++n+
  EFC39412.1 360 QYEIYILFFNLIRMIKSKTLSPTFKNLVLSFLKNITSNGELIMRLYVNFDCKVEKRNI 417
                 ***************5559999********************************9997 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.051
      Sec7_N  60 llkqklcplLlknlsespsfpvferslrivllLlkkfrs 98 
                 l  +++cp++++++ +s+++++ ++++  +  L  k+++
  EFC39412.1 898 LWESHICPFISQIA-SSKNTTLALYCIDSLCKLCMKLLE 935
                 55678999999999.777777776666655555554433 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.13
      Sec7_N   64 klcplLlknlsespsfpvferslrivllLlkkfrseLktEievflsllilillesds 120 
                   l  +  k  +e +s +++++ ++ +ll +  f +++++E+ + + ++i+ ll+++ 
  EFC39412.1 1172 ILPTCFRKESKEFKSLKLVTVGCSNLLLFIDLFGENFTEECWMNVCEIIKNLLTENV 1228
                  333333333334556668888889999999999999999999999999999987743 PP

>> DUF1981  Domain of unknown function (DUF1981)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.16   7.3e+02      59      83 ..      94     118 ..      92     119 .. 0.90
   2 ?   -1.2   0.0      0.42   1.9e+03      22      47 ..     372     397 ..     361     401 .. 0.81
   3 !    5.8   0.0    0.0027        12      38      65 ..     792     819 ..     784     830 .. 0.89
   4 !   44.8   0.3   1.9e-15   8.5e-12      11      67 ..     940     996 ..     932    1015 .. 0.88
   5 ?   -1.0   0.0      0.36   1.6e+03      58      82 ..    1072    1097 ..    1066    1126 .. 0.60

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.16
     DUF1981  59 ifgvltaaakeeneslvrlafqilk 83 
                  f+vl+++ k ++ +++ +a+++l+
  EFC39412.1  94 YFKVLNLSCKTKQANIIMIALDLLQ 118
                 599******************9987 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.42
     DUF1981  22 eeimsnnssaeirelvlecveqliqs 47 
                   i s++ s + ++lvl+ +++++++
  EFC39412.1 372 RMIKSKTLSPTFKNLVLSFLKNITSN 397
                 5566888899999*****99999875 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.0027
     DUF1981  38 lecveqliqsraeniksGWktifgvlta 65 
                 l+ + +l +++++nik +W  i+ +++ 
  EFC39412.1 792 LKLLLELAETEGNNIKDAWSDIIDIIAE 819
                 566788999****************976 PP

  == domain 4  score: 44.8 bits;  conditional E-value: 1.9e-15
     DUF1981  11 fkfQkefLkPFeeimsnnssaeirelvlecveqliqsraeniksGWktifgvltaaa 67 
                   +Q++fL+PF  i++++ ++e+r+lv ++v+q++  r++ ik GWk +fg+l+++a
  EFC39412.1 940 IDYQQQFLQPFTRIYQTCLDKEVRKLVTQSVHQIVLVRSSFIKPGWKELFGMLSMTA 996
                 568**************************************************9987 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 0.36
     DUF1981   58 tifgvl.taaakeeneslvrlafqil 82  
                  +i++   t+++++++e++  +af+ l
  EFC39412.1 1072 QILSSYaTVVSNDNREEVQIKAFKAL 1097
                  44444313344455555555565543 PP

>> DCB  Dimerisation and cyclophilin-binding domain of Mon2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.4   6.4   1.1e-17   4.7e-14      22     175 ..      57     217 ..      40     219 .. 0.87
   2 ?   -1.2   0.2      0.31   1.4e+03      28     113 ..     246     338 ..     229     388 .. 0.61
   3 ?    0.3   0.1       0.1   4.7e+02      82     107 ..     876     901 ..     780     904 .. 0.68
   4 ?    3.0   1.6     0.015        69      22      96 ..     867     938 ..     850     981 .. 0.62
   5 ?   -3.9   0.0       2.1   9.5e+03     125     146 ..    1157    1178 ..    1143    1191 .. 0.54

  Alignments for each domain:
  == domain 1  score: 52.4 bits;  conditional E-value: 1.1e-17
         DCB  22 krkhskvkeasekgilkLktikssseeeeqslaeaseeilkPlllacetknpkivqiaLgslqrLisheviseea........iskiietlwkllel.g 111
                  rk  ++k+a+  ++ +Lk ++++  e+e++l+++ + ++k l l+c+tk++ i+ iaL+ lq++++ ++i+  +        ++ ++ tl ++++  +
  EFC39412.1  57 NRKLIELKDACVLVVEHLKVCENNF-EVERDLIQNPNMYFKVLNLSCKTKQANIIMIALDLLQQFMEKNYINFYTkfdenlliTDVMMRTLSECVDIsN 154
                 69999*****************999.789*******************************************444445667756667889999998743 PP

         DCB 112 ve..ielkvLqtllllvttssvvhgdtlakalvlCfrLhfskdnvvqntAaAtlrQlvsvvFeRvv 175
                 ++  ++l+ L+t+l+++++++ + g++l+  + +C ++hf ++n +++ +   l+Q++++v +R+ 
  EFC39412.1 155 QDesLQLQFLKTILTAISSCH-LSGKSLLIGVKVCLSVHFVSKNETNTFS--VLKQVLHMVINRMD 217
                 3359*************9986.89******************99887665..7***********94 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.31
         DCB  28 vkeasekgilkLktikssseeeeqslaeaseeilkPlllacetknpkivqiaL......gslqrLisheviseeaiskiietl.wkllelgve 113
                 vk++  +   +L+++ ++++++   +++ s ++ k + ++    ++k++ i L      ++ ++L+sh+ + e+  s + +tl ++l+++++ 
  EFC39412.1 246 VKDEDRHTHKELTELTQKQRDAILVFKYLSASVSKDFTNGPFDEKAKLTYIDLltdvfkNCGRKLLSHQRVFEQVKSIVCQTLlINLVHCKST 338
                 555555566666666666655566666666666666666666666666655543333334566777777777666666666541445544433 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.1
         DCB  82 slqrLisheviseeaiskiietlwkl 107
                  l++ i+  +++ ++i++i++tlw+ 
  EFC39412.1 876 YLKKVIESLYLNMHRINTILDTLWES 901
                 46777777788888899999999876 PP

  == domain 4  score: 3.0 bits;  conditional E-value: 0.015
         DCB  22 krkhskvkeasekgilkLktikssseeeeqslaeaseeilkPlllac.etknpkivqiaLgslqrLisheviseea 96 
                 k+k++++    +k+i  L    ++    ++ l    e+ + P++    ++kn+ +   +++sl +L  ++++++e+
  EFC39412.1 867 KKKSTNLIFYLKKVIESLYLNMHRI---NTILDTLWESHICPFISQIaSSKNTTLALYCIDSLCKLC-MKLLEQES 938
                 4444444444444444443333333...333444457789999877658999999999999999997.56666666 PP

  == domain 5  score: -3.9 bits;  conditional E-value: 2.1
         DCB  125 lvttssvvhgdtlakalvlCfr 146 
                     +++    +++ ++l +Cfr
  EFC39412.1 1157 SYFSDNSAALKSIFEILPTCFR 1178
                  3333344455556666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       918  (0.051202); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.90u 0.34s 00:00:01.24 Elapsed: 00:00:00.52
# Mc/sec: 8066.32
//
Query:       EFC39413.1  [L=347]
Description: hypothetical protein NAEGRDRAFT_72850 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-08   35.2  26.4    0.00063   20.1   1.5    5.4  6  LRR_4       Leucine Rich repeats (2 copies)
    0.00013   21.8   0.5    0.00013   21.8   0.5    2.3  2  F-box-like  F-box-like
    0.00016   21.5  25.1        1.7    8.9   0.1    7.5  8  LRR_6       Leucine Rich repeat
    0.00094   19.0   0.2     0.0034   17.2   0.2    2.0  1  F-box       F-box domain
     0.0038   16.9  25.6      0.009   15.8   3.9    4.4  3  LRR_8       Leucine rich repeat
  ------ inclusion threshold ------
      0.024   15.3   1.7        4.1    8.2   0.2    3.3  2  LRR_2       Leucine Rich Repeat
      0.029   14.2   0.1       0.28   11.0   0.1    2.3  2  AHD         ANC1 homology domain (AHD)
       0.79    9.7   3.9       0.97    9.4   1.1    2.8  2  LRR_3       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.58   1.3e+03      10      32 ..      75      99 ..      68     105 .. 0.72
   2 !   16.5   3.3   3.9e-06    0.0087       1      36 [.     146     179 ..     146     190 .. 0.88
   3 !   11.7   2.4   0.00012      0.27       1      39 [.     167     205 ..     167     212 .. 0.79
   4 ?    5.2   1.8     0.014        31       2      33 ..     194     231 ..     193     240 .. 0.70
   5 !    7.9   1.5     0.002       4.4       2      39 ..     222     263 ..     221     268 .. 0.68
   6 !   20.1   1.5   2.8e-07   0.00063       2      32 ..     278     314 ..     277     323 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.58
                SS---.E-S-HHH.-TT--EEE-.- CS
       LRR_4 10 nNqlt.dipllek.lpnLkeLdLsg 32
                +N++   ++ + k + nLk + L g
  EFC39413.1 75 SNRVGvALQKITKpFENLKIVKLYG 99
                5777766666778899999998855 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 3.9e-06
                 SS--EEE--SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsgNnli 36 
                 ++ +vL+L++N +  ++l + +++LkeL+L ++n++
  EFC39413.1 146 KKIRVLNLNDNDIEMLELEY-FTKLKELHL-RCNNL 179
                 5789***********99999.*********.77666 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 0.00012
                 SS--EEE--SS---E-S-HH...H-TT.--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpn.LkeLdLsgNnlitdl 39 
                 ++L++L+L+ N+l + + ++    +++ L+ LdLs N    ++
  EFC39413.1 167 TKLKELHLRCNNLHSPSIIQqisECKSqLTCLDLSMN----SF 205
                 79*******9999986664455348889******888....54 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.014
                 S--EEE--SS---E-S-..HH....H.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl..le....k.lpnLkeLdLsgN 33 
                 +L+ LdLs N  + ++   l       + +L++L+Lsg 
  EFC39413.1 194 QLTCLDLSMNSFS-LQHveLIaaneTlNHSLRKLNLSGS 231
                 6999999988866.5554311355544688******986 PP

  == domain 5  score: 7.9 bits;  conditional E-value: 0.002
                 S--EEE--SS---E-S-....HHH.-TT--EEE-...-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl....lek.lpnLkeLdL..sgNnlitdl 39 
                 +L++L+Ls+   +   +    l + ++nL++L+L    ++++td+
  EFC39413.1 222 SLRKLNLSGSEFSG--PvlklL-SrFTNLTHLTLkwMYCTNPTDV 263
                 79******867775..243533.55********864345566676 PP

  == domain 6  score: 20.1 bits;  conditional E-value: 2.8e-07
                 S--EEE--SS-......--E-S-HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNq......ltdiplleklpnLkeLdLsg 32 
                 +L++L+++nN+      l+ i++ ++++nL++L+Ls+
  EFC39413.1 278 KLTSLNFANNKtmltriLKAISNSSSMKNLTYLNLSS 314
                 7*********9**9999999999999*********76 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.5   5.9e-08   0.00013       2      36 ..       3      37 ..       2      41 .. 0.92
   2 ?   -1.5   1.2       1.1   2.5e+03      28      36 ..      55      63 ..      55      71 .. 0.78

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 5.9e-08
  F-box-like  2 srLPdEiLlqIFsyLppsdLlrlalVCrrWrrval 36
                ++LP E++  I ++ ++++++  ++VCr W++++ 
  EFC39413.1  3 QHLPAELINLIMEFCDQYEIIHFTAVCRCWHECIE 37
                69******************************995 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.1
  F-box-like 28 CrrWrrval 36
                CrrW + +l
  EFC39413.1 55 CRRWFNTCL 63
                999987765 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       4.2   9.4e+03      16      23 ..     109     116 ..     108     117 .. 0.80
   2 !    5.4   0.1    0.0099        22       4      15 ..     147     158 ..     144     159 .. 0.88
   3 !    8.9   0.1   0.00076       1.7       3      16 ..     167     180 ..     167     185 .. 0.87
   4 !    5.7   0.2     0.008        18       3      15 ..     193     205 ..     191     208 .. 0.85
   5 !    7.0   0.1    0.0031       6.9       2      16 ..     220     234 ..     219     241 .. 0.88
   6 ?   -1.2   0.4       1.3   2.9e+03       3      12 ..     245     254 ..     245     254 .. 0.81
   7 ?    2.2   0.1      0.11   2.5e+02       4      14 ..     278     288 ..     276     299 .. 0.85
   8 !    5.8   0.0    0.0072        16       3      22 ..     305     324 ..     303     326 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 4.2
       LRR_6  16 gDeGaeaL 23 
                 + eG+ aL
  EFC39413.1 109 NSEGVAAL 116
                 679**999 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0099
       LRR_6   4 hLteLdLsgNdI 15 
                 +++ L+L++NdI
  EFC39413.1 147 KIRVLNLNDNDI 158
                 6899*******9 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.00076
       LRR_6   3 thLteLdLsgNdIg 16 
                 t+L+eL+L++N++ 
  EFC39413.1 167 TKLKELHLRCNNLH 180
                 68**********85 PP

  == domain 4  score: 5.7 bits;  conditional E-value: 0.008
       LRR_6   3 thLteLdLsgNdI 15 
                 + Lt LdLs N +
  EFC39413.1 193 SQLTCLDLSMNSF 205
                 67*********75 PP

  == domain 5  score: 7.0 bits;  conditional E-value: 0.0031
       LRR_6   2 nthLteLdLsgNdIg 16 
                 n++L++L+Lsg +++
  EFC39413.1 220 NHSLRKLNLSGSEFS 234
                 99********98766 PP

  == domain 6  score: -1.2 bits;  conditional E-value: 1.3
       LRR_6   3 thLteLdLsg 12 
                 t+Lt+L L++
  EFC39413.1 245 TNLTHLTLKW 254
                 6899999876 PP

  == domain 7  score: 2.2 bits;  conditional E-value: 0.11
       LRR_6   4 hLteLdLsgNd 14 
                 +Lt+L+ + N+
  EFC39413.1 278 KLTSLNFANNK 288
                 7*******997 PP

  == domain 8  score: 5.8 bits;  conditional E-value: 0.0072
       LRR_6   3 thLteLdLsgNdIgDeGaea 22 
                  +Lt+L+Ls+ ++  e ++ 
  EFC39413.1 305 KNLTYLNLSSSGVKEEDLIE 324
                 58*******98887666665 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.2   1.5e-06    0.0034       5      42 ..       4      41 ..       3      47 .. 0.89

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 1.5e-06
                HS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHH CS
       F-box  5 rLPsevlrhILerLplsdllalrrVSkgwrilidsdrl 42
                 LP e+++ I+e+++  +++ +  V++ w+ +i    l
  EFC39413.1  4 HLPAELINLIMEFCDQYEIIHFTAVCRCWHECIEVRQL 41
                69******************************976555 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   3.9     4e-06     0.009       2      60 ..     147     204 ..     146     205 .. 0.88
   2 ?    4.4   5.6     0.014        31       2      57 ..     194     253 ..     193     254 .. 0.82
   3 ?    4.7   3.4     0.011        25      25      58 ..     277     314 ..     264     316 .. 0.56

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 4e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G..GGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsgNr 60 
                 + ++L+L++N ++ l+ e F+   +Lk+L+L++N+l++  + ++  ++ ++L+ LdLs N 
  EFC39413.1 147 KIRVLNLNDNDIEMLELEYFT---KLKELHLRCNNLHSpsIIQQISECKSQLTCLDLSMNS 204
                 5789*****************...8***********9877778888888888888888875 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.014
                 T-SEEE-TTS-..-SEE-TTSSTT..-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   2 nLtsLdLsnNr..ltslddeaFkg..lsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 +Lt LdLs N+  l++++  a +   +++L+ L+Ls  + +    + +s +++L++L+L 
  EFC39413.1 194 QLTCLDLSMNSfsLQHVELIAANEtlNHSLRKLNLSGSEFSGPVLKLLSRFTNLTHLTLK 253
                 56777777776667777777777766789*************889************995 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.011
                 TT--EEE--SS..---GGGGGGG...TT--S-.EEE--S CS
       LRR_8  25 snLkvLdLsnN..llttlspgaf...sgLpsLrsLdLsg 58 
                  +L++L+  nN   lt++  +a+   s++++L++L+Ls+
  EFC39413.1 277 AKLTSLNFANNktMLTRI-LKAIsnsSSMKNLTYLNLSS 314
                 566666666664334444.23331114466666666664 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.025        56       1      11 [.     168     178 ..     168     184 .. 0.85
   2 ?    8.2   0.2    0.0018       4.1       1      25 [.     222     244 ..     222     244 .. 0.95

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.025
       LRR_2   1 sLKtLhLdsVr 11 
                 +LK LhL+++ 
  EFC39413.1 168 KLKELHLRCNN 178
                 6*******987 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0018
       LRR_2   1 sLKtLhLdsVrfsdedslekLLSgC 25 
                 sL+ L+L+  +fs+   + kLLS +
  EFC39413.1 222 SLRKLNLSGSEFSGP--VLKLLSRF 244
                 8**************..******75 PP

>> AHD  ANC1 homology domain (AHD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   0.00012      0.28       1      42 [.     164     205 ..     164     211 .. 0.90
   2 ?    0.1   0.0      0.33   7.4e+02      13      33 ..     282     302 ..     272     308 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00012
         AHD   1 ekleeLkeLqkklmsltdrkvlqrivdiIeetGlyeitestf 42 
                 e++ +LkeL+ + ++l+ ++++q+i +  ++  +++++ ++f
  EFC39413.1 164 EYFTKLKELHLRCNNLHSPSIIQQISECKSQLTCLDLSMNSF 205
                 5789*********************99988888888888777 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.33
         AHD  13 lmsltdrkvlqrivdiIeetG 33 
                 l+  +++  l ri + I++++
  EFC39413.1 282 LNFANNKTMLTRILKAISNSS 302
                 555678999999999999887 PP

>> LRR_3  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       3.1     7e+03       5      16 ..     151     162 ..     151     163 .. 0.83
   2 ?    9.4   1.1   0.00043      0.97       1      14 [.     168     181 ..     168     181 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3.1
       LRR_3   5 LnmpySkLeKLW 16 
                 Ln+  + +e L 
  EFC39413.1 151 LNLNDNDIEMLE 162
                 899999999985 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00043
       LRR_3   1 nLVeLnmpySkLeK 14 
                 +L+eL++++++L++
  EFC39413.1 168 KLKELHLRCNNLHS 181
                 69**********95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       587  (0.0327403); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.66u 0.28s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1918.86
//
Query:       EFC39414.1  [L=431]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.4e-17   61.0  40.1    1.4e-05   25.3   1.1    6.9  7  LRR_4     Leucine Rich repeats (2 copies)
    1.7e-15   55.6  40.9     0.0073   16.3   0.8    9.5 11  LRR_6     Leucine Rich repeat
    1.3e-10   40.9  40.2    7.5e-05   22.4   9.7    6.3  7  LRR_8     Leucine rich repeat
    3.3e-06   26.7   8.8       0.14   11.7   2.7    3.8  3  LRR_9     Leucine-rich repeat
     0.0001   22.3  31.2       0.34   11.6   0.5    8.6  7  LRR_1     Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.2       0.2     7e+02      16      30 ..      92     106 ..      73     117 .. 0.66
   2 !   25.3   1.1   3.9e-09   1.4e-05       1      39 [.     145     180 ..     145     184 .. 0.94
   3 !   21.3  12.6   7.4e-08   0.00027       1      39 [.     191     230 ..     191     258 .. 0.90
   4 !   12.2   4.6   5.3e-05      0.19       2      35 ..     240     275 ..     239     284 .. 0.81
   5 !   13.6   2.6   1.9e-05     0.067       2      33 ..     264     296 ..     263     301 .. 0.87
   6 !   11.4   0.0   9.3e-05      0.33       3      37 ..     313     347 ..     311     353 .. 0.68
   7 ?   -2.5   0.0       2.2   7.8e+03      28      35 ..     371     378 ..     369     386 .. 0.63

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.2
                 -S-HHH-TT--EEE- CS
       LRR_4  16 iplleklpnLkeLdL 30 
                 ++l+++l +L eL +
  EFC39414.1  92 LELFGNLESLIELEC 106
                 334678999999988 PP

  == domain 2  score: 25.3 bits;  conditional E-value: 3.9e-09
                 SS--EEE--SS---.E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLsgNnlitdl 39 
                 p+Le+L+ ++N+++ +++ l++l+nL++L Ls+N    d+
  EFC39414.1 145 PKLEYLSVRHNNIKgELDRLGNLKNLTSLILSDN----DI 180
                 79***************************99***....76 PP

  == domain 3  score: 21.3 bits;  conditional E-value: 7.4e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 + L++L+LsnN + d  l  ++kl nL++LdL+gN +i+++
  EFC39414.1 191 TTLKYLNLSNNSIGDSFLmdFNKLINLTYLDLNGN-NIGNI 230
                 579***********96669999**********999.77776 PP

  == domain 4  score: 12.2 bits;  conditional E-value: 5.3e-05
                 S--EEE--SS---E-S-HH.H.-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdiplle.k.lpnLkeLdLsgNnl 35 
                 n e L Ls N + + +l + + l +L+ L+L+gNn 
  EFC39414.1 240 NIEQLILSYNLIGEEGLKNyGtLRKLRILNLNGNNI 275
                 7899*****9***877744655*********99943 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 1.9e-05
                 S--EEE--SS---.E-S-HHH-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqlt.diplleklpnLkeLdLsgN 33 
                 +L++L+L++N+++  +  l+ + +L  L++  N
  EFC39414.1 264 KLRILNLNGNNIRnGLKYLSACESLDRLSICAN 296
                 8************99888999********9666 PP

  == domain 6  score: 11.4 bits;  conditional E-value: 9.3e-05
                 --EEE--SS---E-S-HH...H-TT--EEE-.-S---- CS
       LRR_4   3 LevLdLsnNqltdiplle...klpnLkeLdLsgNnlit 37 
                  ++L++s+N + d  +++    l++L+eL L +N  i+
  EFC39414.1 313 VKILHISDNPIGD--GFShfpLLKQLTEL-LANNCEIG 347
                 689*********7..65511136666666.97775555 PP

  == domain 7  score: -2.5 bits;  conditional E-value: 2.2
                 EE-.-S-- CS
       LRR_4  28 LdLsgNnl 35 
                 L+++gNn+
  EFC39414.1 371 LSITGNNF 378
                 67777743 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       2.4   8.8e+03       4      12 ..       3      11 ..       2      12 .. 0.82
   2 ?   -2.9   0.1         3   1.1e+04       3      10 ..      73      80 ..      72      80 .. 0.81
   3 !    9.9   0.0   0.00023      0.82       1      18 [.     143     160 ..     143     160 .. 0.89
   4 !    9.8   0.6   0.00024      0.88       3      20 ..     168     185 ..     166     187 .. 0.86
   5 !   14.2   0.4   9.5e-06     0.034       3      17 ..     191     205 ..     189     206 .. 0.92
   6 !   16.3   0.8     2e-06    0.0073       4      20 ..     216     232 ..     213     236 .. 0.87
   7 !    8.9   0.2   0.00048       1.7       1      21 [.     237     257 ..     237     258 .. 0.92
   8 !    8.9   0.8   0.00046       1.7       3      17 ..     263     277 ..     261     278 .. 0.89
   9 !   12.1   0.0   4.4e-05      0.16       2      17 ..     310     325 ..     309     326 .. 0.93
  10 ?   -2.7   0.1       2.4   8.7e+03      11      17 ..     341     348 ..     340     348 .. 0.72
  11 ?   -0.6   0.0      0.52   1.9e+03       8      16 ..     371     379 ..     370     386 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.4
       LRR_6  4 hLteLdLsg 12
                +L+ +dL++
  EFC39414.1  3 TLEIVDLQC 11
                899999986 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3
       LRR_6  3 thLteLdL 10
                 +L++L L
  EFC39414.1 73 KTLKSLRL 80
                69***987 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00023
       LRR_6   1 snthLteLdLsgNdIgDe 18 
                 + ++L++L++++N+I +e
  EFC39414.1 143 HLPKLEYLSVRHNNIKGE 160
                 5689***********986 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00024
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                  +Lt+L Ls+NdI D G+
  EFC39414.1 168 KNLTSLILSDNDIFDGGC 185
                 68**********988875 PP

  == domain 5  score: 14.2 bits;  conditional E-value: 9.5e-06
       LRR_6   3 thLteLdLsgNdIgD 17 
                 t+L++L+Ls N IgD
  EFC39414.1 191 TTLKYLNLSNNSIGD 205
                 89************9 PP

  == domain 6  score: 16.3 bits;  conditional E-value: 2e-06
       LRR_6   4 hLteLdLsgNdIgDeGa 20 
                 +Lt+LdL+gN+Ig+ Ga
  EFC39414.1 216 NLTYLDLNGNNIGNIGA 232
                 8*************998 PP

  == domain 7  score: 8.9 bits;  conditional E-value: 0.00048
       LRR_6   1 snthLteLdLsgNdIgDeGae 21 
                 sn +++ L Ls+N Ig eG++
  EFC39414.1 237 SNINIEQLILSYNLIGEEGLK 257
                 58899**************97 PP

  == domain 8  score: 8.9 bits;  conditional E-value: 0.00046
       LRR_6   3 thLteLdLsgNdIgD 17 
                 ++L+ L+L+gN+I +
  EFC39414.1 263 RKLRILNLNGNNIRN 277
                 79***********86 PP

  == domain 9  score: 12.1 bits;  conditional E-value: 4.4e-05
       LRR_6   2 nthLteLdLsgNdIgD 17 
                 ++h++ L++s+N IgD
  EFC39414.1 310 SSHVKILHISDNPIGD 325
                 69*************9 PP

  == domain 10  score: -2.7 bits;  conditional E-value: 2.4
       LRR_6  11 sgNd.IgD 17 
                 + N+ IgD
  EFC39414.1 341 ANNCeIGD 348
                 56777*99 PP

  == domain 11  score: -0.6 bits;  conditional E-value: 0.52
       LRR_6   8 LdLsgNdIg 16 
                 L+++gN+++
  EFC39414.1 371 LSITGNNFT 379
                 899****98 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.1      0.48   1.7e+03      18      30 ..      92     104 ..      73     105 .. 0.63
   2 !   21.7   1.1   3.5e-08   0.00013      23      61 .]     143     180 ..     120     180 .. 0.85
   3 !   19.3   5.5     2e-07   0.00071      25      61 .]     191     227 ..     186     227 .. 0.93
   4 !   22.4   9.7   2.1e-08   7.5e-05       2      61 .]     216     275 ..     215     275 .. 0.98
   5 !   11.1   4.7     7e-05      0.25       2      61 .]     240     298 ..     239     298 .. 0.87
   6 !    6.9   0.2    0.0015       5.3       2      59 ..     287     344 ..     286     346 .. 0.79
   7 ?    0.7   0.1      0.13   4.6e+02       6      24 ..     371     389 ..     370     391 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.48
                 TTSSTT-TT--EE CS
       LRR_8  18 deaFkglsnLkvL 30 
                  e F +l++L +L
  EFC39414.1  92 LELFGNLESLIEL 104
                 4667888888776 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 3.5e-08
                 T-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8  23 glsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 +l++L++L+ ++N+++  l  + + +L++L+sL Ls+N++
  EFC39414.1 143 HLPKLEYLSVRHNNIKGeL--DRLGNLKNLTSLILSDNDI 180
                 6****************55..7****************97 PP

  == domain 3  score: 19.3 bits;  conditional E-value: 2e-07
                 TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  25 snLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + Lk+L+LsnN++       f  L +L++LdL+gN++
  EFC39414.1 191 TTLKYLNLSNNSIGDSFLMDFNKLINLTYLDLNGNNI 227
                 67*************99******************97 PP

  == domain 4  score: 22.4 bits;  conditional E-value: 2.1e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+LdL+ N++ +++    +++ n + L Ls+Nl+     +    L++Lr L+L+gN++
  EFC39414.1 216 NLTYLDLNGNNIGNIGANYLSSNINIEQLILSYNLIGEEGLKNYGTLRKLRILNLNGNNI 275
                 8*********************************************************98 PP

  == domain 5  score: 11.1 bits;  conditional E-value: 7e-05
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 n + L+Ls N + + + +   +l++L++L+L+ N+++    + +s ++sL+ L +  N++
  EFC39414.1 240 NIEQLILSYNLIGEEGLKNYGTLRKLRILNLNGNNIRNG-LKYLSACESLDRLSICANHI 298
                 6678999999999999999999**************995.37899999999999888886 PP

  == domain 6  score: 6.9 bits;  conditional E-value: 0.0015
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgN 59 
                 +L +L+++ N++++     F +  s++k+L++s+N +   +s   f  L++L++L  +++
  EFC39414.1 287 SLDRLSICANHINAQAVIEFCQlSSHVKILHISDNPIGDgFS--HFPLLKQLTELLANNC 344
                 79999******999999999996789*********7766455..7777777777766665 PP

  == domain 7  score: 0.7 bits;  conditional E-value: 0.13
                 EE-TTS--SEE-TTSSTT- CS
       LRR_8   6 LdLsnNrltslddeaFkgl 24 
                 L+++ N++t+l  + F ++
  EFC39414.1 371 LSITGNNFTKLAVQKFLKF 389
                 8899999999999888765 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.7   0.1   7.7e-05      0.28      79     127 ..     136     182 ..     112     195 .. 0.80
   2 !   11.7   2.7   3.8e-05      0.14      47     131 ..     196     281 ..     184     286 .. 0.88
   3 !    5.4   0.0    0.0032        12      47      76 ..     316     346 ..     307     383 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 7.7e-05
       LRR_9  79 iaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                   e+++  lP+le l + +n+++  ++ld l +lk+l++l l +n + +
  EFC39414.1 136 SIEEIDVHLPKLEYLSVRHNNIK--GELDRLGNLKNLTSLILSDNDIFD 182
                 34788999************998..68999**********999998865 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 3.8e-05
       LRR_9  47 idlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkey 131
                 ++ls+n i +  l +f  l  l  l ln n i +i+ +   +  n+e+l+l+ n + e + l+   +l+kl++l l  n + n  +y
  EFC39414.1 196 LNLSNNSIGDsfLMDFNKLINLTYLDLNGNNIGNIGANYLSSNINIEQLILSYNLIGEEG-LKNYGTLRKLRILNLNGNNIRNGLKY 281
                 68899999654488999999******************999999************9965.7999***********99999887776 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0032
       LRR_9  47 idlsdndirk.ldgfPllkrlktlllnnnri 76 
                 +++sdn i + +  fPllk+l  ll nn  i
  EFC39414.1 316 LHISDNPIGDgFSHFPLLKQLTELLANNCEI 346
                 57899999754899*************9877 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.2     0.029     1e+02       1      15 [.     146     160 ..     146     167 .. 0.79
   2 ?    3.1   0.2     0.061   2.2e+02       1      14 [.     169     182 ..     169     189 .. 0.87
   3 !    9.4   0.3   0.00051       1.8       2      15 ..     193     206 ..     192     214 .. 0.79
   4 !   11.6   0.5   9.5e-05      0.34       1      21 [.     216     236 ..     216     254 .. 0.94
   5 ?    5.1   3.1     0.013        46       1      13 [.     264     276 ..     264     309 .. 0.81
   6 ?    3.8   0.2     0.034   1.2e+02       3      16 ..     314     327 ..     312     350 .. 0.80
   7 ?   -2.1   0.0         3   1.1e+04       5      14 ..     371     380 ..     370     389 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.029
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 +L++L +++n++ g 
  EFC39414.1 146 KLEYLSVRHNNIKGE 160
                 7**********8544 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.061
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL++L Ls+n +++
  EFC39414.1 169 NLTSLILSDNDIFD 182
                 8*********9965 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00051
       LRR_1   2 LrhLdLsnnpllgl 15 
                 L++L+Lsnn++++ 
  EFC39414.1 193 LKYLNLSNNSIGDS 206
                 9*********9644 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 9.5e-05
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++LdL++n+++++++n+++
  EFC39414.1 216 NLTYLDLNGNNIGNIGANYLS 236
                 8************99999987 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.013
       LRR_1   1 nLrhLdLsnnpll 13 
                 +Lr L+L++n++ 
  EFC39414.1 264 KLRILNLNGNNIR 276
                 7*********982 PP

  == domain 6  score: 3.8 bits;  conditional E-value: 0.034
       LRR_1   3 rhLdLsnnpllglp 16 
                 + L++s+np+++  
  EFC39414.1 314 KILHISDNPIGDGF 327
                 89*******95333 PP

  == domain 7  score: -2.1 bits;  conditional E-value: 3
       LRR_1   5 LdLsnnpllg 14 
                 L +++n+++ 
  EFC39414.1 371 LSITGNNFTK 380
                 7899999864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (431 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       458  (0.0255452); expected 358.6 (0.02)
Passed bias filter:                      295  (0.0164538); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2676.35
//
Query:       EFC39415.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-19   70.6  25.9    1.4e-19   70.2  25.9    1.1  1  CRT-like  CRT-like, chloroquine-resistance transporter-like
  ------ inclusion threshold ------
       0.38   10.7   3.6        1.1    9.3   3.6    1.7  1  Toxin_21  Spider insecticidal peptide


Domain annotation for each model (and alignments):
>> CRT-like  CRT-like, chloroquine-resistance transporter-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.2  25.9   1.6e-23   1.4e-19       2     334 .]      36     387 ..      35     387 .. 0.78

  Alignments for each domain:
  == domain 1  score: 70.2 bits;  conditional E-value: 1.6e-23
    CRT-like   2 liyvvllvlsgviNsillKkvlnklkNy.sfflnqltnfvyvpiffavvly.kllltnd....ipketrsfpkrkFai....mgaLDavsgilvvigav 90 
                 +++v+++++ g++N++ ++ +   ++ y s fl   t+f+y  +f +  ++ +++++++    i +     ++ k +i    +g+  a++gi++  +  
  EFC39415.1  36 IVLVIIYLMGGMMNNLGVQIMGYYMPLYnSGFLLYGTTFMYTSFFIVTEIFlSIVVQKHsfkqIKERWCLYYNKKLIIcvlaLGFFTAFNGIFAQSAIP 134
                 7899***********999998877776633477778889999888776554134444332111333333455666554333378999********9999 PP

    CRT-like  91 stsGslqvllnqaiipitllasllllkerysliqylGAlviilgvvvvlipsllgesse....gnklvfnllllisviPvalSnvykeiafkeveldvl 185
                  +  +l  +l+q++ p+t ++  l+l+++y l q++  l+i+ g++   i s + ++ +    +n+ ++ ++ ++s iP+a+ ++y+e+a+ +++  + 
  EFC39415.1 135 FVDPELTAILTQVSAPLTWIMYPLILRKKYDLGQIGCFLLILSGLLFGSIYSYMNGTGSettfSNSAFWLIISICSAIPTAFETIYQEVAYDSYKAPTF 233
                 99*******************************************98777776653333123369*****************************99998 PP

    CRT-like 186 yLqawvalfqlligilllpvnal.llkpakikfke.ileslkdGlaCllgkntiveev...lscgldeq..kscDdCekawivvllyllvNiiyNilil 277
                  + ++  lf l++    + + ++   +  +++ +  +     + ++C +   ++ e+    ++c  ++   +sc   ++a++   ++++   +y +  +
  EFC39415.1 234 IVLVYYNLFSLIVYAAWMFMTMVpNFGSCNVPAHTpLSMCSMNATTCSAT--QVFEQQgeaFQCFFGNYdvSSCCGGWQATLWTCIFVAGYYVYFVSGS 330
                 88888899999887755555555455666665543133344567777654..45554455447865544116666678999****************** PP

    CRT-like 278 lvlkhagatvlsiastlrlPltnivfslkfivgkevtplsaldvaglliillGlvlY 334
                 ++++++g++vl   ++l  Plt++ f +k +vg+ ++++    +++l+ii lG ++Y
  EFC39415.1 331 YLIEKFGSNVLANLNALLYPLTAVCFWIKPLVGQFSSQPTWWIIVSLIIITLGNIGY 387
                 *******************************************************99 PP

>> Toxin_21  Spider insecticidal peptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   3.6   0.00012       1.1      13      27 ..     304     318 ..     300     321 .. 0.88

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00012
    Toxin_21  13 dCCsGkCaivWtCil 27 
                  CC+G  a +WtCi+
  EFC39415.1 304 SCCGGWQATLWTCIF 318
                 6************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       986  (0.0549947); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.28s 00:00:00.91 Elapsed: 00:00:00.47
# Mc/sec: 3093.78
//
Query:       EFC39416.1  [L=379]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
       0.11   12.9   2.5       0.34   11.3   2.5    1.8  1  DUF5406        Family of unknown function (DUF5406)


Domain annotation for each model (and alignments):
>> DUF5406  Family of unknown function (DUF5406)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   2.5   1.9e-05      0.34      54     109 ..     133     188 ..     120     191 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 1.9e-05
     DUF5406  54 erlgqklsdetyalkllgeddegkewleailindkkdeletedewdaLsemlvkie 109
                  +  +k s+ + +l++l edde + +++ +l++ +k +++ + + ++ +++l+k +
  EFC39416.1 133 TQYATKRSEIKQDLTQLQEDDENQYMFKKVLQQMQKIDMDYQKDIQEYKKYLIKKD 188
                 57788999999******************************************865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (379 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1800  (0.100396); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.24s 00:00:00.80 Elapsed: 00:00:00.42
# Mc/sec: 2690.55
//
Query:       EFC39417.1  [L=831]
Description: abc transmembrane transporter [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.8e-40  136.5  22.5    1.1e-39  136.0  22.5    1.2  1  ABC2_membrane    ABC-2 type transporter
    7.2e-27   94.6   0.3    3.7e-26   92.3   0.1    2.4  3  ABC_tran         ABC transporter
    3.7e-06   26.3  17.1    3.7e-06   26.3  17.1    2.5  3  ABC2_membrane_3  ABC-2 family transporter protein
     0.0015   18.4   0.2      0.093   12.5   0.1    2.4  2  AAA_21           AAA domain, putative AbiEii toxin, Type IV T
  ------ inclusion threshold ------
      0.013   14.9   0.0      0.032   13.7   0.0    1.6  1  SMC_N            RecF/RecN/SMC N terminal domain
      0.017   15.0   0.1      0.017   15.0   0.1    2.5  3  RsgA_GTPase      RsgA GTPase
      0.021   15.1   0.5          1    9.6   0.1    3.2  3  AAA_22           AAA domain
      0.022   13.6   0.4      0.053   12.4   0.1    1.8  2  AAA_35           AAA-like domain


Domain annotation for each model (and alignments):
>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  136.0  22.5     5e-43   1.1e-39       1     210 []     552     763 ..     552     763 .. 0.95

  Alignments for each domain:
  == domain 1  score: 136.0 bits;  conditional E-value: 5e-43
  ABC2_membrane   1 tqikallkreflqrwrdpslgllwrliqplllalvfgtvfgnlg.nsedglnrpgllffsvlflafsaltsvapvferergvlerelvsplyslsa 95 
                    tq+++++ r+fl+++rd   +   r+iq +++a+++g+++++++ ++++++n +gllff v++   +++ + +++f  er  + re+ ++ +s s+
     EFC39417.1 552 TQFLVMFLRSFLNQYRDFKFT-KIRVIQQIIYAILVGFIYFQTKnDQNSVQNKLGLLFFVVTNQWSNSFGTPISIFRGERLYFLRERGAKCFSISS 646
                    69*******************.88********************557777799************888888877777777777************* PP

  ABC2_membrane  96 yvlakvlvelpvsllqalifllivyflvgldls..rfflflllllltalaasslgllisalapsfedasqlaslvllpllllsGffipidsmpkwl 189
                    y+++k+++++++++   + f +ivy+l gl+l+  rf++f+l++l++++aa s+g+++++l++ +e a++l + + + + ++sGf+ +id++p++l
     EFC39417.1 647 YYFGKFFADMLLIIPHPVFFGTIVYLLAGLTLTidRFLMFILIILVLSQAAHSFGMVLAILVRRVEIATMLLPPISTTFHVFSGFYRNIDQIPVYL 742
                    ************************************************************************************************ PP

  ABC2_membrane 190 qwiaylnPltyavealrsnlf 210
                     w+ y++P+ y+++al++n+f
     EFC39417.1 743 AWFTYFSPFNYGFKALIVNEF 763
                    ******************997 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       2.6   5.9e+03     121     135 ..      23      37 ..      13      39 .. 0.76
   2 ?   -3.2   0.0       4.8   1.1e+04      26      48 ..     169     189 ..     169     238 .. 0.65
   3 !   92.3   0.1   1.7e-29   3.7e-26       4     136 ..     260     406 ..     257     407 .. 0.95

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.6
                 HHHHHTSSEEEEEST CS
                 xxxxxxxxxxxxxxx RF
    ABC_tran 121 rallkkpkllllDEp 135
                  + + + ++++lDE 
  EFC39417.1  23 IVHADEENIIILDET 37 
                 45568899*****96 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 4.8
                 HHHHHHTTSS--SEEEEEETTCE CS
                 xxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  26 tLlkllagllkpteGeilldgkd 48 
                 tL+ ++ +l++pt+G+   ++ d
  EFC39417.1 169 TLVDVVKKLVSPTKGSF--RKSD 189
                 78888999999999987..2222 PP

  == domain 3  score: 92.3 bits;  conditional E-value: 1.7e-29
                 EEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH................HHHTCHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................xxxxxxx RF
    ABC_tran   4 vslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren................esdeeie 86 
                 ++   ++g+++ai+ ++GaGK++Ll++lag++k t+Gei ++g  +k+    +l++ +g++ q++ l  +ltvre+                e+ ++++
  EFC39417.1 260 IDGIAYPGSILAIMAPSGAGKTSLLNILAGQTKCTSGEIIINGMVVKN----RLKSLVGYVYQDDLLMGNLTVRETlrysamlklpsttsyqEKMKKVD 354
                 5566789**************************************999....9***********************************999888888** PP

                 HHHHHSTTGGTTCBGESTTS..GGS-HHHHHHHHHHHHHHHTSSEEEEESTT CS
                 xxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  87 kalsklglkelkdtvvkssp..ssLSgGqkqrvalarallkkpkllllDEpt 136
                  +l+ l+l++++dt +++ +  + +SgG+++r+ +a all++p++l+lDEp+
  EFC39417.1 355 YVLQLLKLEKCADTLIGEVGlsKGISGGERKRLGIAIALLTNPPILILDEPS 406
                 ****************999999*****************************7 PP

>> ABC2_membrane_3  ABC-2 family transporter protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   1.9       3.1   6.9e+03      62      94 ..      70     102 ..      24     172 .. 0.46
   2 ?    0.5   0.0      0.11   2.5e+02     280     340 ..     454     591 ..     430     592 .. 0.74
   3 !   26.3  17.1   1.6e-09   3.7e-06     201     343 ..     643     817 ..     641     819 .. 0.75

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 3.1
  ABC2_membrane_3  62 yevdseeeakkalkngdidgilvipkgfskdll 94 
                      +  +++ ++  a++n+  ++  v +++ + +++
       EFC39417.1  70 EISPNTPNLLYAIDNNVDNHHKVYYSNSLSNIE 102
                      333344444444444444444444444444443 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.11
  ABC2_membrane_3 280 lsgffgglfpledlpsalkwi.fsiiPffapglgllrlitgdplwe................................................ 324
                      +sg ++++++++++ +++k+i f ++ ++ p+++ +++it d+ +                                                 
       EFC39417.1 454 ASGKIAYFGSTSKVVKYFKKIgFAMNDNYNPADFVMDMITEDSHAIfahekthesemerinkivdsfekikqqiipsvhdtfelrectlpkvek 547
                      5555555565665556666655778888888888888887774444667777777777777777777777777777777777777777777777 PP

  ABC2_membrane_3 325 ............................illsliilalfavvyl 340
                                                  +++ +i+ +l +++y+
       EFC39417.1 548 stwwtqflvmflrsflnqyrdfkftkirVIQQIIYAILVGFIYF 591
                      77777777777777777777888888888888888888888887 PP

  == domain 3  score: 26.3 bits;  conditional E-value: 1.6e-09
  ABC2_membrane_3 201 splqywlskilgdflvyllqlllilll...afglgipfgnlglllllfllfglayialgyllsslfknsetaqilifivilllsgffgglfple 291
                      s ++y+++k+++d+l+ +   +++  +   + gl ++++ ++ ++l +l+ + a+ ++g++l  l+++ e a  l+++++ ++ +f+g+   ++
       EFC39417.1 643 SISSYYFGKFFADMLLIIPHPVFFGTIvylLAGLTLTIDRFLMFILIILVLSQAAHSFGMVLAILVRRVEIATMLLPPISTTFHVFSGFYRNID 736
                      6689**************887766543333666568888999999999999******************************************* PP

  ABC2_membrane_3 292 dlpsalkwifsiiPffapglgllrli......tgdplwe.............................illsliilalfavvyllla 343
                      ++p +l+w++++ Pf++ +++l+  +            +                             ++ +l+i ++++v + ++a
       EFC39417.1 737 QIPVYLAWFTYFSPFNYGFKALIV-NefggrtI-----DcptdqdescpypnldfildyygmnnglmnTWVNLGIVLGISVGMRIIA 817
                      *****************9988843.23333330.....1444444444444444444444444444447777777777776666665 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.024        55       7      21 ..     275     289 ..     269     352 .. 0.86
   2 !   12.5   0.1   4.1e-05     0.093     238     299 ..     380     439 ..     370     440 .. 0.87

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.024
      AAA_21   7 pNgsGKSnLLdaldl 21 
                 p g+GK++LL +l +
  EFC39417.1 275 PSGAGKTSLLNILAG 289
                 88**********975 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 4.1e-05
      AAA_21 238 SdGtkrllalltallralkkgsllliDEpEngLHPkllrrllellkelsr.ngaQviltTHSp 299
                 S G ++ l+++ all  +   ++l++DEp ++L+ k    +++ ++  ++ +++ vi+t H+p
  EFC39417.1 380 SGGERKRLGIAIALLTNP---PILILDEPSTSLDSKTALDVVQTISHVAKtHNITVIMTIHQP 439
                 889999989999***999...**************9999999999666666789999998877 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0   1.4e-05     0.032     135     195 ..     106     433 ..       6     442 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.4e-05
                 T.................................................................................................. CS
                 x.................................................................................................. RF
       SMC_N 135 e.................................................................................................. 135
                                                                                                                    
  EFC39417.1 106 Pnsstssdethilveddynisldlskiirthekqieehsmkktgssysirkmnskdsaktptetlvdvvkklvsptkgsfrksdvvsyseiyldqfqdw 204
                 244445555555555555555555555555555555555555555555555555555666666666666666677778888888888888888888888 PP

                 ................................................................................................... CS
                 ................................................................................................... RF
       SMC_N 136 ................................................................................................... 135
                                                                                                                    
  EFC39417.1 205 knekhetgaiiswrnicyqvkretsflndiiskslkkegdskmekpskfiqilngidgiaypgsilaimapsgagktsllnilagqtkctsgeiiingm 303
                 888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888888 PP

                 ..........................................................................CS-HHHHHHHHHHHHHHHHCCS--S CS
                 ..........................................................................xxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 ..........................................................................lLSgGektLvalaLlfAiqkvkpap 160
                                                                                            +SgGe++ + +a    i      p
  EFC39417.1 304 vvknrlkslvgyvyqddllmgnltvretlrysamlklpsttsyqekmkkvdyvlqllklekcadtligevglskGISGGERKRLGIA----IALLTNPP 398
                 8888888888888888888888888888888888888888888888888888888888888888888888888899*****966655....5567889* PP

                 EEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 161 lyllDeidaaLDeknvkkvaellkeksknaQfivi 195
                 + +lDe    LD k    v++ + +  k+  + vi
  EFC39417.1 399 ILILDEPSTSLDSKTALDVVQTISHVAKTHNITVI 433
                 ***********************987776555554 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.6   3.5e+03      48      89 ..     124     164 ..     117     181 .. 0.70
   2 ?   15.0   0.1   7.7e-06     0.017     100     130 ..     268     298 ..     260     302 .. 0.89
   3 ?   -2.2   0.0       1.5   3.3e+03      12      42 ..     423     454 ..     409     518 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.6
                  EEEEEEE-GGG--HHHHHHHHHHHHHHTTSEEEE--TTTHTT CS
  RsgA_GTPase  48 epvivlnKiDlleeeeeleelkeelealgyevllvsaktkeg 89 
                  ++ + l+Ki  ++e++ +ee + + +   y++ ++++k++++
   EFC39417.1 124 NISLDLSKIIRTHEKQ-IEEHSMKKTGSSYSIRKMNSKDSAK 164
                  5667788888888888.9998888888889999888886543 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 7.7e-06
                  SEEEEECSTTSSHHHHHHHHCTT-----S-- CS
  RsgA_GTPase 100 ktsvlvGqSGvGKStLinallpelelktgev 130
                  ++ +++ +SG+GK++L+n l+++++   ge+
   EFC39417.1 268 SILAIMAPSGAGKTSLLNILAGQTKCTSGEI 298
                  678999*****************99988887 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 1.5
                  TEES--EEEEEEESTTTT--.HHHHHHHHHHH CS
  RsgA_GTPase  12 kvaNvdqllivvslkepels.lnlldrfLvla 42 
                  +va   ++ +++++++p+ + l+ ld +L+la
   EFC39417.1 423 HVAKTHNITVIMTIHQPRSDiLDYLDNLLLLA 454
                  47888888888888888776235666666655 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.29   6.4e+02      84     135 ..      13      70 ..       2      71 .. 0.57
   2 ?    9.6   0.1   0.00046         1       5      28 ..     267     290 ..     264     314 .. 0.90
   3 ?    0.0   0.0      0.42   9.3e+02      92     131 ..     397     438 ..     340     444 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.29
      AAA_22  84 qalrarav........ielliiDEaqhlrseealeeLrsllnlsrkgvqliLvGtpelrk 135
                 q + +r++          ++i+DE     + ++  e+ + +  ++++++ + +Gtpe+++
  EFC39417.1  13 QSSMTRRRtaivhadeENIIILDETKQN-ETKQTLEIPTTAR-EHTKTKTVNFGTPEIYE 70 
                 4444444423333333466777776665.4444444433333.69999999999999987 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00046
      AAA_22   5 agilvvtGesGtGKTtllrrlleq 28 
                  +il+++++sG+GKT ll+ l+ q
  EFC39417.1 267 GSILAIMAPSGAGKTSLLNILAGQ 290
                 589**************9988766 PP

  == domain 3  score: 0.0 bits;  conditional E-value: 0.42
      AAA_22  92 ielliiDEaqh.lrs...eealeeLrsllnlsrkgvqliLvGtp 131
                 +++li+DE    l+s    ++++++++ ++  ++++++i+ +++
  EFC39417.1 397 PPILILDEPSTsLDSktaLDVVQTISHVAK--THNITVIMTIHQ 438
                 679999999998984245777777777777..999999998765 PP

>> AAA_35  AAA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   2.4e-05     0.053      26      56 ..     262     292 ..     254     307 .. 0.85
   2 ?   -3.0   0.0       1.1   2.4e+03      48      83 ..     417     452 ..     411     473 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2.4e-05
      AAA_35  26 eiekpGalirikapkkmGKtSLlarilakak 56 
                  i  pG+++ i ap+  GKtSLl+ +  ++k
  EFC39417.1 262 GIAYPGSILAIMAPSGAGKTSLLNILAGQTK 292
                 6889*******************97765554 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.1
      AAA_35  48 larilakakqqgyktvsldlqladkeilsdldkflr 83 
                 + +++++++++++ tv + +++  ++il+ ld++l 
  EFC39417.1 417 VVQTISHVAKTHNITVIMTIHQPRSDILDYLDNLLL 452
                 567788888889999999999999999999999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (831 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1305  (0.0727871); expected 358.6 (0.02)
Passed bias filter:                      630  (0.0351386); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.82u 0.32s 00:00:01.13 Elapsed: 00:00:00.49
# Mc/sec: 5101.23
//
Query:       EFC39418.1  [L=193]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    7.3e-07   29.7   0.0    1.5e-06   28.7   0.0    1.6  2  OTU          OTU-like cysteine protease
  ------ inclusion threshold ------
      0.068   13.5   0.0       0.13   12.6   0.0    1.5  1  AAA_assoc_2  AAA C-terminal domain


Domain annotation for each model (and alignments):
>> OTU  OTU-like cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.62   5.6e+03       9      38 ..       3      31 ..       1      53 [. 0.56
   2 !   28.7   0.0   1.7e-10   1.5e-06       2      79 ..      60     141 ..      59     186 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.62
                HHHHHCCCSS.SHCCHHHHHHHHHCHHHHH CS
         OTU  9 ravsqqlwgvsdelrkakvseLreklaeyl 38
                +++s++ + ++ ++++ k ++Lr+ +a+ +
  EFC39418.1  3 KSISRKQFTNFSSNNR-KINYLRNFSASRF 31
                5666555544433222.4566666555544 PP

  == domain 2  score: 28.7 bits;  conditional E-value: 1.7e-10
                 -SS-HHHHHHHHCCCSS.SHCCHHHHHHHHHCHHHHHH.........TSSHHCCHHHHCCHHH..HHHHTTSTTHHHHHHHHHHHHHHC CS
         OTU   2 gDGnCLlravsqqlwgvsdelrkakvseLreklaeylr.........ehseelelfleeeeeg..ylkeiektaawggeleifalahiL 79 
                 +DGnCL+++ s+++       + +++++Lre+ +  +r          +  + +lf+ee +++  yl+  +k + +g+ + + a++ + 
  EFC39418.1  60 SDGNCLYDSLSKGIN------NGKNHQKLREEIVGWMRnnletkidgLEL-KHALFVEEGQSFdeYLNSLSKSGTFGDFTSVVAASRVY 141
                 7*************6......55578899999988888555544433222.22344444433388*************99999999886 PP

>> AAA_assoc_2  AAA C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   1.5e-05      0.13      41      73 ..     158     189 ..     129     193 .] 0.84

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 1.5e-05
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXHHHHH CS
  AAA_assoc_2  41 egkieitledleealqrkalryDkagdehYdli 73 
                  ++ ie++ e+++++ ++  l yD+ + +hYdli
   EFC39418.1 158 SEVIEVNPEHVKNVNKEVWLSYDE-KKQHYDLI 189
                  68899******************9.68*****9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (193 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1125.34
//
Query:       EFC39419.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.029   14.3   0.0      0.049   13.5   0.0    1.3  1  Inhibitor_I48  Peptidase inhibitor clitocypin
      0.077   13.1   0.0       0.31   11.1   0.0    2.1  2  Arm            Armadillo/beta-catenin-like repeat


Domain annotation for each model (and alignments):
>> Inhibitor_I48  Peptidase inhibitor clitocypin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   5.5e-06     0.049      14      91 ..      43     122 ..      32     143 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.5e-06
  Inhibitor_I48  14 atGglyatgngvdkivavasqvpvlfdrqvW...kieavhGkkeaytsisihtlGgnwtskdgesiPetPvvtseesyeff 91 
                    + Ggl    n + + +++asq p+ f+  +    k++  +   ea+   ++  l  +w+sk   +iP+  +  s +   f 
     EFC39419.1  43 SKGGLIILTNFLRDEISIASQKPSCFNMATSllvKLTNMRENIEAFRESGFVKLIAEWFSKSPCPIPQPNL-ESYNAALFN 122
                    6799************************998889*************99999***************7544.444443444 PP

>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0      0.85   7.6e+03       3      15 ..      83      95 ..      82      97 .. 0.81
   2 ?   11.1   0.0   3.5e-05      0.31       4      41 .]     130     166 ..     126     166 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 0.85
                HHHHHHHHTTHHH CS
         Arm  3 enkdavieaGavp 15
                en++a +e+G v+
  EFC39419.1 83 ENIEAFRESGFVK 95
                7999999999886 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 3.5e-05
                 HHHHHHHTTHHHHHHHHTTTSSHHHHHHHHHHHHHHTT CS
         Arm   4 nkdavieaGavppLvrLLssedeevqeeAawALsNLaa 41 
                 +k+++ +a +vp+L+r+ + +d +v   Aa  L+NL+a
  EFC39419.1 130 QKILLSHA-IVPQLIRFANGKDKQVSSFAAKSLWNLSA 166
                 55555566.***************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       533  (0.0297284); expected 358.6 (0.02)
Passed bias filter:                      422  (0.0235373); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1219.90
//
Query:       EFC39420.1  [L=238]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-07   31.4   0.0     0.0077   16.2   0.0    3.7  3  Arm              Armadillo/beta-catenin-like repeat
     0.0059   16.1   0.4      0.016   14.7   0.2    1.8  2  Ribonuc_red_sm   Ribonucleotide reductase, small chain
  ------ inclusion threshold ------
      0.026   14.5   9.1       0.13   12.2   1.5    3.1  2  DUF3361          Domain of unknown function (DUF3361)
      0.039   14.0   4.8       0.38   10.8   0.6    3.0  4  Atx10homo_assoc  Spinocerebellar ataxia type 10 protein domai
        0.1   10.9   0.1       0.18   10.1   0.1    1.3  1  CCD48            Coiled-coil domain-containing protein 48
       0.17   12.3   0.1         61    4.3   0.0    3.3  3  HEAT             HEAT repeat
        2.8    8.6   6.5        2.5    8.8   0.4    2.8  3  MSP7_C           MSP7-like protein C-terminal domain


Domain annotation for each model (and alignments):
>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.0     3e-06    0.0077      11      40 ..      14      45 ..      10      46 .. 0.95
   2 !    8.7   0.0   0.00071       1.8       7      32 ..      73      97 ..      70      99 .. 0.92
   3 ?    1.6   0.0      0.12     3e+02       6      27 ..     214     235 ..     212     238 .] 0.87

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 3e-06
                TTHHHHHHHHTT..TSSHHHHHHHHHHHHHHT CS
         Arm 11 aGavppLvrLLs..sedeevqeeAawALsNLa 40
                +G++p+ ++LL+    d ++++++++ L NLa
  EFC39420.1 14 LGGIPIIISLLNdqQNDKRIVKNVLGILLNLA 45
                7******************************9 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00071
                HHHHTTHHHHHHHHTTTSSHHHHHHH CS
         Arm  7 avieaGavppLvrLLssedeevqeeA 32
                a+ie+ ++ +Lv+L ++ d ++++e 
  EFC39420.1 73 AIIEY-GIGALVNLCEDNDASIRKEM 97
                79999.****************9985 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.12
                 HHHHHTTHHHHHHHHTTTSSHH CS
         Arm   6 davieaGavppLvrLLssedee 27 
                 +++++ G v+  v+ L++++ e
  EFC39420.1 214 KLLVKEGFVEKMVSVLENPNSE 235
                 5799*************88875 PP

>> Ribonuc_red_sm  Ribonucleotide reductase, small chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.42   1.1e+03      44      63 ..      28      47 ..      23      77 .. 0.76
   2 !   14.7   0.2   6.3e-06     0.016     175     241 ..      80     144 ..      68     172 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.42
                    HHHHHHHHHHHHHHHHHHHH CS
  Ribonuc_red_sm 44 edekefikkvlaflalldti 63
                    +++k+++k+vl++l +l t+
      EFC39420.1 28 QNDKRIVKNVLGILLNLATL 47
                    67899999999988766555 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 6.3e-06
                     TSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTT CS
  Ribonuc_red_sm 175 gllpglaeiielilrDeglHtdfagllfkelkeenelenkeleeeveelikeavelEkefitdalpv 241
                     g l +l+e ++  +r e +  + ++ +f+e+++   ++++e++ +v +li   + lE  fit++++ 
      EFC39420.1  80 GALVNLCEDNDASIRKEMVNQENSIKVFSEILKD-AKFTEEMKRNVLSLIS-FLSLEPTFITKIVKA 144
                     7799***************************888.999**********996.7899****9999855 PP

>> DUF3361  Domain of unknown function (DUF3361)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   1.5   5.1e-05      0.13      57     150 ..      19     111 ..      16     114 .. 0.83
   2 ?    4.0   5.3     0.017        44      12      84 ..      58     133 ..      53     237 .. 0.55

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.1e-05
     DUF3361  57 kiasivnksaadasilqrslaiLesivlnsselyelvekevtlesLiehLqssnqe..iqtnalaLlnALllkaddskrkelaetlskkqlrkvil 150
                  i+s +n ++ d++i+++ l iL ++++ ++ + +++++ +    + + L+++++e  i  + +  l  L+   d s rke++++ ++ ++ + il
  EFC39420.1  19 IIISLLNDQQNDKRIVKNVLGILLNLATLDK-CRNEIKSGIS--MIFKVLENHSSElaIIEYGIGALVNLCEDNDASIRKEMVNQENSIKVFSEIL 111
                 68999*********************99998.7888888776..4777777666665589999999999*************99988877766665 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.017
     DUF3361  12 lkllvkiveegkesgeilayaLtafleLmdhgivsW..dtlsdeF.ikkiasivnksaadasilqrslaiLesivl 84 
                 +++++k++e+ + +  i++y + a+++L + +  s   +++++e  ik   +i++  + ++++ ++ l+ +  + l
  EFC39420.1  58 ISMIFKVLENHSSELAIIEYGIGALVNLCEDNDASIrkEMVNQENsIKVFSEILKDAKFTEEMKRNVLSLISFLSL 133
                 5555555555555445555555555555444332221133333220222222222223333333333333332222 PP

>> Atx10homo_assoc  Spinocerebellar ataxia type 10 protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.89   2.3e+03      23      42 ..      11      30 ..       6      45 .. 0.72
   2 ?   10.8   0.6   0.00015      0.38      26      91 ..      55     121 ..      31     128 .. 0.75
   3 ?   -2.0   0.0       1.4   3.7e+03       1      15 [.     120     134 ..     118     143 .. 0.81
   4 ?    3.8   0.1     0.023        59      15      72 ..     162     218 ..     157     233 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.89
  Atx10homo_assoc 23 vreldgleliLsqcniDdnn 42
                     + +l+g+++i+s  n ++n+
       EFC39420.1 11 IHRLGGIPIIISLLNDQQND 30
                     67788888888776655554 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00015
  Atx10homo_assoc  26 ldgleliLsqcniDdnnPfirewailairnLlegneen..qelvaeLeakgvvdeevLeelgleveid 91 
                      ++g+++i +  + ++++  i e++i a+ nL+e+n ++  +e+v++ +  + v +e L++++++ e++
       EFC39420.1  55 KSGISMIFKVLENHSSELAIIEYGIGALVNLCEDNDASirKEMVNQENSIK-VFSEILKDAKFTEEMK 121
                      4689999999999999*******************9875345555544444.6678888888777764 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 1.4
  Atx10homo_assoc   1 fKrelvrllgnlvyk 15 
                      +Kr++++l+++l+ +
       EFC39420.1 120 MKRNVLSLISFLSLE 134
                      699999999999766 PP

  == domain 4  score: 3.8 bits;  conditional E-value: 0.023
  Atx10homo_assoc  15 knkevqdkvreldgleliLsqcniDdnnPfirewailairnLlegneenqelvaeLea 72 
                        ++ q+   +++ l ++ +q+ + +    ir  +++++ nL+ +  e+ ++ + L +
       EFC39420.1 162 MAQKLQNSANDQSLLRILVKQIDLTQL-EQIRSKTVFCVYNLIVSDDESGSIQKLLVK 218
                      566777777777777777777777655.468999********9988887655544444 PP

>> CCD48  Coiled-coil domain-containing protein 48
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.1   6.9e-05      0.18     508     552 ..      28      73 ..      19      83 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 6.9e-05
       CCD48 508 lrdlniskralGkil.lstldacrdpaqeGksgplavldalhrala 552
                   d  i k +lG +l l+tld cr+  + G s  ++vl+     la
  EFC39420.1  28 QNDKRIVKNVLGILLnLATLDKCRNEIKSGISMIFKVLENHSSELA 73 
                 467889******988799********************98877776 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.0     0.024        61       2      17 ..      17      32 ..      17      46 .. 0.81
   2 ?    3.9   0.0     0.031        81       4      18 ..      81      95 ..      79      99 .. 0.88
   3 ?   -1.6   0.0       1.9   4.8e+03      15      27 ..     190     202 ..     189     203 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.024
                HHHHHHHHT-SSHHHH CS
        HEAT  2 lPlllkllsDpspeVR 17
                +P++++ll+D+  + R
  EFC39420.1 17 IPIIISLLNDQQNDKR 32
                79********776655 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.031
                HHHHHHT-SSHHHHH CS
        HEAT  4 lllkllsDpspeVRe 18
                +l++l++D+++++R+
  EFC39420.1 81 ALVNLCEDNDASIRK 95
                6899*********97 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 1.9
                 HHHHHHHHHHHHH CS
        HEAT  15 eVReaAakaLgal 27 
                 ++R+ ++ ++ +l
  EFC39420.1 190 QIRSKTVFCVYNL 202
                 589999**99887 PP

>> MSP7_C  MSP7-like protein C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.2      0.11   2.8e+02      43      81 ..      27      67 ..      21      79 .. 0.75
   2 ?    8.8   0.4   0.00099       2.5      66      98 ..      98     130 ..      69     140 .. 0.77
   3 ?   -0.7   0.0      0.82   2.1e+03      27      38 ..     158     167 ..     132     202 .. 0.53

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.11
      MSP7_C 43 nekEyeiikkLidaffkk..eenenskadslveifkkaLkd 81
                ++++  i+k+ + ++++    ++ +++ +s ++++ k+L++
  EFC39420.1 27 QQNDKRIVKNVLGILLNLatLDKCRNEIKSGISMIFKVLEN 67
                678999*****999998776555556666666666777776 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00099
      MSP7_C  66 skadslveifkkaLkdkkfreefknfiyglYsf 98 
                  ++++ +++f   Lkd kf ee+k  + +l sf
  EFC39420.1  98 VNQENSIKVFSEILKDAKFTEEMKRNVLSLISF 130
                 2344679****************9888777766 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.82
      MSP7_C  27 eskynnfkkeyd 38 
                   ky    ++ +
  EFC39420.1 158 TGKYMA--QKLQ 167
                 444433..1222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (238 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1170  (0.0652574); expected 358.6 (0.02)
Passed bias filter:                      486  (0.0271069); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.45
# Mc/sec: 1586.56
//
Query:       EFC39421.1  [L=499]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.8e-44  150.4   3.5    1.2e-41  142.8   3.5    2.3  1  Oxysterol_BP  Oxysterol-binding protein


Domain annotation for each model (and alignments):
>> Oxysterol_BP  Oxysterol-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.8   3.5   6.9e-46   1.2e-41       2     360 ..     108     490 ..     107     499 .] 0.83

  Alignments for each domain:
  == domain 1  score: 142.8 bits;  conditional E-value: 6.9e-46
                   HHCCHTT.STT-BCCCS---GGGEEEEEHHHHHHHCCTTCHHHHHHHC.SSHHHHHHHHHHHHHHCCCGCT..STSSSEEE---TT-EEEEEETT.. CS
  Oxysterol_BP   2 lwsilkk.ciGkDLskislPvffneplSlLqrlaedleyselLdkaakeddsleRlayVaaFalSsyasti..krrlkKPFNPlLGEtfelvred.. 93 
                   lw+++k+  +  DL ++  P+f++ p+S+L+ ++ + e +  L+   + d++l+R+++ + F+l s+++t+  +    KP+NP+LGE f+  +++  
    EFC39421.1 108 LWQFIKQlQPQVDLLRMCSPIFIMRPISTLELYTYYTEPTLALKVLREMDSELDRMLCCLLFSLISCSNTFgdSFEGLKPYNPILGEEFHAEWHSsv 204
                   566666523899************************************999*******************98744566***************5556 PP

                   ...CEE.....................................EEEEEEEETTTTEEEEEEEE..CTEEEEEEEEEEEEE-SSEEEEEE-SEEEEEE CS
  Oxysterol_BP  94 ...kgf.....................................rfiaEQVsHhPpvsAfhaes..egweldgeikvkskflgkslevkpeGtahlel 148
                      +                                       ++ aEQVsHhPp+sAf +e+   gw+++ ++++  k+  +++++++ G+  l++
    EFC39421.1 205 neqQ-QeeksgekktamwlenwlsnqtsqdqermqemlkecktKVTAEQVSHHPPISAFLMENekCGWSMKSTFQILAKLKMNYVDLNIAGKHLLQV 300
                   6651.156666777788999999999999999**********9********************7778*************************99998 PP

                   ..EEESEEEEEEE--EEEEE-TTTTS-EEEEEEEEEEEETTT--EEEEEEE---SSS---SSEEEEEEEETTS-EEEEEEEETTTEEEEEETTSTTS CS
  Oxysterol_BP 149 ..lkksgehYtwtkpttivhniivgklwvelsgeveitnhstgdkakleFkkkglfsskksnkvegkvkdkkkevlyeisGkwdeelyikkkktekk 243
                     ++ ++e+Y +t p+++++++ +g+ ++ +++ ++++ +++g ++kl+F  +        n+v+g ++d+k+++l +++G+  ++++i+k ++++ 
    EFC39421.1 301 dlKNGETEEYDFTLPHVYANGLFWGSSTITNGEYLKVKCKKSGLTVKLNFG-S-------GNDVSGSLTDRKGKTLLNLKGNICGKINITKGNSSD- 388
                   756889********************************9999999999998.2.......379**************************5555432. PP

                   --EEEEETT..................-.......BSXXGCGSSTTBCCCCCCH-----...GGG--HHHHCCT---.TTGGS-TTBGGG-HHHHHH CS
  Oxysterol_BP 244 eeeedasek..................s.......kvkekeeqeefeseklWkasplpkaeeyygftkfavtlNeieekekslaptDsRlRpDqral 315
                       ++                     s        vk+ +eq+e es+++W++                vt                       ++
    EFC39421.1 389 -LYPST--LlplifksdlpffeaafckSlpfsnelVVKPLHEQKEYESRRVWHE----------------VTY----------------------NI 444
                   .22221..1234566556555554444144556677888888888888888888................777......................67 PP

                   HTT-HHHHHHHHHHHHHHHHHHHHHH..CCTT----SSEEEEETTTT CS
  Oxysterol_BP 316 eegdideAeeeKkrlEekQRerrker..eekkewkpkwFekekdpdt 360
                    + + d+A + K+++Ee QR+++ +   e+k ++++k F+ + +  +
    EFC39421.1 445 LHDNKDKAFDCKHEIEEIQRAKASKLklEGK-THETKIFKPTGHFSK 490
                   78899******************99966665.8******98776444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (499 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1617  (0.0901891); expected 358.6 (0.02)
Passed bias filter:                      618  (0.0344693); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2846.52
//
Query:       EFC39422.1  [L=398]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      0.002   17.9   0.2     0.0065   16.3   0.1    2.0  2  Glyco_hydro2_C5  Glycoside hydrolase family 2 C-terminal doma
  ------ inclusion threshold ------
       0.08   13.1   3.4       0.18   12.0   0.4    2.7  2  MG4              Macroglobulin domain MG4
       0.14   11.3   1.8       0.17   11.0   0.5    1.7  2  TMEM173          Transmembrane protein 173


Domain annotation for each model (and alignments):
>> Glyco_hydro2_C5  Glycoside hydrolase family 2 C-terminal domain 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   1.1e-06    0.0065      20      68 ..     188     236 ..     167     256 .. 0.81
   2 ?   -2.5   0.0      0.77   4.6e+03      11      34 ..     351     374 ..     349     377 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.1e-06
  Glyco_hydro2_C5  20 vtvevvDknGnlvpnadnevtfeveGpGelvgvdngdptslesfksner 68 
                       tv+++D  Gn+v+++ + ++++ eG+G+l g   +  ++  +  sn++
       EFC39422.1 188 TTVRLLDTSGNTVSTSGESISLSWEGSGTLGGSTTATTSNGVATFSNSI 236
                      58*****************************998777766655555544 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.77
  Glyco_hydro2_C5  11 kadgkDlafvtvevvDknGnlvpn 34 
                      + +g++l++v+ +++   G+ v++
       EFC39422.1 351 TRNGNELTVVNQKATQCSGRAVKT 374
                      567888888888888888887776 PP

>> MG4  Macroglobulin domain MG4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.12   7.4e+02      10      17 ..     106     113 ..     100     115 .. 0.88
   2 ?   12.0   0.4     3e-05      0.18       7      81 ..     177     254 ..     174     269 .. 0.75

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.12
         MG4  10 fKpGlPfs 17 
                 +K+GlPfs
  EFC39422.1 106 YKQGLPFS 113
                 9******8 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 3e-05
         MG4   7 pkffKpGlPfsikVlvkdpdgspaknvpVkiea..lkseteekeslttdedGtakfsintpe.daksltitvktkdps 81 
                 p+ +  G  f+ +V++ d+ g+ ++    +i++   +s+t  ++++ t ++G+a fs  ++  ++ s+++++++ + +
  EFC39422.1 177 PTTVNSGQTFTTTVRLLDTSGNTVSTSGESISLswEGSGTLGGSTTATTSNGVATFSNSITVsSSVSAKLKATYTTGG 254
                 566667889*************998765555553233677778888899********998886777888888776655 PP

>> TMEM173  Transmembrane protein 173
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.5   2.8e-05      0.17      13     124 ..       4     117 ..       1     118 [. 0.86
   2 ?   -1.7   0.0      0.21   1.2e+03      29      65 ..     358     394 ..     354     397 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 2.8e-05
                 XXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXX CS
     TMEM173  13 lgdLlkrlcllveellshvnsryrgslwkalracftlnlkslvllllllllylalssdlglslllalalls....lckllvlllglqklslvevseire 107
                  +++l +++l+v    ++ +  ++ sl+ + ++ f+++++s  ++ + +   ++ +s + ++ ++++ l++    ++ ++++ ++    s  +  +++e
  EFC39422.1   4 TKSILAAIMLFVLM-ACAQQVSSQLSLKAVEQNLFRSPRQSCSCIACTCGGGTCPQS-VAAHAYTSFSLTCptgqVVSSYSVNVQSTDGSSFKYYTVSE 100
                 56788888888888.9999999999999999**********9999999999999888.5566666666666667699999999**************** PP

                 XXX-TCHHHHHHHHHHC CS
     TMEM173 108 kkklnvAhGlAwsyYiG 124
                 +    + +Gl +syY G
  EFC39422.1 101 ADFEKYKQGLPFSYYNG 117
                 ***************98 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.21
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
     TMEM173  29 shvnsryrgslwkalracftlnlkslvllllllllyl 65 
                 + vn++  +   +a++++ ++n+k++ +l+++ll+ +
  EFC39422.1 358 TVVNQKATQCSGRAVKTSGSSNIKQASFLIVCLLVLI 394
                 566777777778999999999**99999999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (398 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       965  (0.0538234); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 2246.86
//
Query:       EFC39423.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.13   13.0   0.8       0.24   12.2   0.8    1.4  1  DUF2626   Protein of unknown function (DUF2626)


Domain annotation for each model (and alignments):
>> DUF2626  Protein of unknown function (DUF2626)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.8   1.3e-05      0.24       4      36 ..       1      33 [.       1      44 [. 0.92

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 1.3e-05
     DUF2626  4 mfRvlgfwtgiiavlafvGdliemallflaqta 36
                mf    f+ +i+a+lafvG  + ++l fl+ t+
  EFC39423.1  1 MFNTKQFLVVILALLAFVGTCQAATLAFLSLTV 33
                788889***********************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       940  (0.052429); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1503.50
//
Query:       EFC39424.1  [L=544]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.5e-24   84.1   0.0    1.5e-23   83.4   0.0    1.3  1  HATPase_c    Histidine kinase-, DNA gyrase B-, and HSP90-like
    7.7e-13   48.3   0.2    2.4e-12   46.7   0.2    1.9  1  HisKA        His Kinase A (phospho-acceptor) domain
     0.0056   16.6   0.9      0.029   14.3   0.1    2.6  2  HATPase_c_5  GHKL domain


Domain annotation for each model (and alignments):
>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.4   0.0   2.5e-27   1.5e-23       2     110 ..     407     521 ..     406     523 .. 0.92

  Alignments for each domain:
  == domain 1  score: 83.4 bits;  conditional E-value: 2.5e-27
                 HHHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE.....EETEEEEEEEESSSSSTTHHHTGTCSTTCH.HCSTCHTSTSSSHHHHHHHHHHHHTTTEEEE CS
   HATPase_c   2 dekrLrqiisnlvdNavkfatkageieveika.....seddlvisveDnGiGipkedlkklfekfsq.ddstkrggggtGlGlsivkklvelmgGeiwv 94 
                 d+++L+qi+snl++Navk+++++ge+++++++     ++ ++++  +D G+Gip+  ++ +fe+f+q +++++++   tGlGl+ v  l++ ++G+i+v
  EFC39424.1 407 DSSKLHQILSNLMTNAVKASKQDGEVRLKCEVleetgEKANIRFVCQDFGCGIPQHLIPSIFEPFVQlQNNSQSKVPSTGLGLTTVSHLIKSLEGTINV 505
                 899***************9779999999999876554338****************************99999999************9999******* PP

                 EEETTTEEEEEEEEES CS
   HATPase_c  95 esepgrGttftftlpl 110
                 es+ g+G+tft+ lp+
  EFC39424.1 506 ESQLGKGSTFTVDLPF 521
                 ************9997 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.7   0.2   4.1e-16   2.4e-12       1      66 [.     288     352 ..     288     353 .. 0.96

  Alignments for each domain:
  == domain 1  score: 46.7 bits;  conditional E-value: 4.1e-16
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHC..T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH CS
       HisKA   1 slgrflagvaHELrtPLsailgnaeaLkregklteelkeyletiesearrldhlvedlLdlsriea 66 
                 +++rf+a+v+HE+r P+ + lg +e+Lk++ +l++++ ++++ti+s+   l+ l+ed+L++ ++e+
  EFC39424.1 288 ARSRFMAHVSHEFRCPIMSSLGCLELLKET-ELNDKQNDLVDTIVSSNGILLLLIEDILQIVKLEH 352
                 589************************996.9*******************************996 PP

>> HATPase_c_5  GHKL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1      0.35   2.1e+03      71      88 ..     373     390 ..     318     398 .. 0.72
   2 !   14.3   0.1   4.9e-06     0.029       5      90 ..     410     508 ..     406     521 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.35
  HATPase_c_5  71 lksireivkkykgnlsie 88 
                  lks++ i++ y  n++++
   EFC39424.1 373 LKSMKGIIQGYASNFKVN 390
                  678888888888777766 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 4.9e-06
  HATPase_c_5   5 dlcvilgnlLdNAieacskieeekrfIrltvrekk.ksliisieNsyeg..................ekkklesskskkeehGiGlksireivkkykg 83 
                   l  il+nl+ NA+ a+++    +  ++++v e+  ++  i++  +  +                  +    ++s+sk    G+Gl+++++++k+ +g
   EFC39424.1 410 KLHQILSNLMTNAVKASKQDG--EVRLKCEVLEETgEKANIRFVCQ--DfgcgipqhlipsifepfvQ--LQNNSQSKVPSTGLGLTTVSHLIKSLEG 501
                  6889************99844..34444444433323333333322..22244666666655543322..33355677899***************** PP

  HATPase_c_5  84 nlsieae 90 
                  ++++e +
   EFC39424.1 502 TINVESQ 508
                  *999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (544 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       831  (0.0463495); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 3336.15
//
Query:       EFC39425.1  [L=112]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-12   48.0  25.1    3.1e-07   30.9   7.9    2.4  2  Antistasin  Antistasin family


Domain annotation for each model (and alignments):
>> Antistasin  Antistasin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   9.3   6.2e-09   0.00011       1      26 []      35      61 ..      35      61 .. 0.95
   2 !   30.9   7.9   1.7e-11   3.1e-07       1      26 []      66      92 ..      66      92 .. 0.96

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 6.2e-09
  Antistasin  1 CpslnCelrCpyGyqtDenGCpi.CeC 26
                C+ ++C + C yGy++D  GC+i C C
  EFC39425.1 35 CRNIYCLIPCRYGYKVDRFGCQIaCDC 61
                88888******************9*** PP

  == domain 2  score: 30.9 bits;  conditional E-value: 1.7e-11
  Antistasin  1 CpslnCelrCpyGyqtDenGCpi.CeC 26
                C+ +nC   Cp+Gy++DenGC++ C C
  EFC39425.1 66 CRVYNCLVACPHGYKVDENGCQVaCDC 92
                88899*****************99*** PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (112 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       557  (0.031067); expected 358.6 (0.02)
Passed bias filter:                      187  (0.01043); expected 358.6 (0.02)
Passed Vit filter:                        11  (0.000613531); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.47u 0.27s 00:00:00.74 Elapsed: 00:00:00.46
# Mc/sec: 731.78
//
Query:       EFC39426.1  [L=307]
Description: ankyrin repeat domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.8e-08   33.5   0.0    1.2e-07   32.2   0.0    1.7  1  Ank_2     Ankyrin repeats (3 copies)
      3e-07   30.2   0.1     0.0044   17.4   0.0    2.9  2  Ank_3     Ankyrin repeat
      3e-07   30.9   0.2    6.4e-05   23.4   0.1    1.9  2  Ank_4     Ankyrin repeats (many copies)
    1.2e-06   28.7   0.2      0.016   15.5   0.1    2.6  2  Ank_5     Ankyrin repeats (many copies)
    0.00026   21.3   0.1       0.16   12.5   0.0    2.7  2  Ank       Ankyrin repeat
  ------ inclusion threshold ------
      0.092   12.1   0.0         15    4.8   0.0    2.5  3  MTD       methylene-5,6,7,8-tetrahydromethanopterin dehydroge


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.2   0.0     4e-11   1.2e-07      21      79 ..     158     223 ..     121     227 .. 0.79

  Alignments for each domain:
  == domain 1  score: 32.2 bits;  conditional E-value: 4e-11
       Ank_2  21 dpnkngktaLhyAakngnleivklLleh....ad....ndgrtpLhyAarsghleivklLlekgadi 79 
                  pn  + +aLh+A+ +g++++v +Ll      +d      +rtpL++A+ +g  +i+++Lle+ga +
  EFC39426.1 158 TPN-GNVSALHVAVAKGQVDLVYWLLYRlrcnVDgfgsPGNRTPLFIACLKGKCQIARILLECGACK 223
                 233.4589**************99996456454466667799**********99*******999754 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.9   0.0   0.00041       1.2       4      29 ..     164     189 ..     161     191 .. 0.84
   2 !   17.4   0.0   1.5e-06    0.0044       2      27 ..     197     221 ..     196     221 .. 0.94

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00041
       Ank_3   4 tpLhlAarsgnleivkfLlenkgadv 29 
                 ++Lh+A+  g +++v +Ll    ++v
  EFC39426.1 164 SALHVAVAKGQVDLVYWLLYRLRCNV 189
                 89****************97655555 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 1.5e-06
       Ank_3   2 GetpLhlAarsgnleivkfLlenkga 27 
                 ++tpL++A++ g++ i++ Lle +ga
  EFC39426.1 197 NRTPLFIACLKGKCQIARILLE-CGA 221
                 69********************.986 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.0   4.1e-05      0.12      28      55 .]     155     182 ..     148     182 .. 0.85
   2 !   23.4   0.1   2.1e-08   6.4e-05       3      55 .]     164     217 ..     162     217 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 4.1e-05
       Ank_4  28 naqdnrsGetalhiAakrgnveilklLl 55 
                 n  +++   +alh A+ +g+v+ + +Ll
  EFC39426.1 155 NTNTPNGNVSALHVAVAKGQVDLVYWLL 182
                 5555777779*****************8 PP

  == domain 2  score: 23.4 bits;  conditional E-value: 2.1e-08
       Ank_4   3 taLhyaaisgrlelvrlLlek.gadinaq.dnrsGetalhiAakrgnveilklLl 55 
                 +aLh a+++g+++lv +Ll++ + +++   +++  +t+l iA+++g+ +i++ Ll
  EFC39426.1 164 SALHVAVAKGQVDLVYWLLYRlRCNVDGFgSPG-NRTPLFIACLKGKCQIARILL 217
                 79*****************77667766664444.779*************99987 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   5.3e-06     0.016       7      41 ..     154     188 ..     150     194 .. 0.76
   2 !   10.6   0.0   0.00019      0.56      16      41 ..     197     218 ..     189     224 .. 0.83

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 5.3e-06
       Ank_5   7 advnrldgggntpLhvAakygaadvvrlLl.argad 41 
                 +++n+++g  +++LhvA+ +g  d+v +Ll   +++
  EFC39426.1 154 INTNTPNG-NVSALHVAVAKGQVDLVYWLLyRLRCN 188
                 56666654.46*******************555554 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00019
       Ank_5  16 gntpLhvAakygaadvvrlLlargad 41 
                   tpL +A+ +g ++++r+Ll     
  EFC39426.1 197 NRTPLFIACLKGKCQIARILL----E 218
                 44*******************....3 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.0    0.0063        19       4      27 ..     164     189 ..     162     190 .. 0.80
   2 !   12.5   0.0   5.3e-05      0.16       3      26 ..     198     222 ..     197     228 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0063
                 BHHHHHHHHTTHHHHHHHH.T.TTST CS
         Ank   4 TPLHlAatngkkriiklLL.h.GAnl 27 
                 ++LH+A+  g+++ + +LL + ++n+
  EFC39426.1 164 SALHVAVAKGQVDLVYWLLyRlRCNV 189
                 79*****999999**99994345666 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 5.3e-05
                 BBHHHHHHHHTTHHHHHHHH.TTTS CS
         Ank   3 nTPLHlAatngkkriiklLL.hGAn 26 
                 +TPL +A+  gk +i++ LL +GA+
  EFC39426.1 198 RTPLFIACLKGKCQIARILLeCGAC 222
                 6*******99**********99*97 PP

>> MTD  methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.1   3.3e+03     124     142 ..      52      70 ..      48      71 .. 0.84
   2 ?    4.4   0.0    0.0065        19     146     199 ..      97     149 ..      90     161 .. 0.79
   3 ?    4.8   0.0    0.0051        15     136     193 ..     211     268 ..     207     280 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.1
                 T--HHHHHHHHHHHHHHHH CS
         MTD 124 fLDptemalfnadvlkvLa 142
                  +D + m  f++++ k L+
  EFC39426.1  52 SMDEVSMIRFDSNLFKSLT 70 
                 579999*******999885 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0065
                 HHHHHHHHHHHHHHHHTTT-GGGS-EEEESGGGGGGSS--SSHHHHHHHHHHHH CS
         MTD 146 avRlvqeeldkviekvkagkeielPkividaekaveaaefsnPYakakalaaye 199
                 + + +qe+l+++ie+ + g+ + lP++++++ k++ + + ++ Y   +   +++
  EFC39426.1  97 VSKWIQEHLQTMIEN-QYGDFHPLPHLLVNNYKCLLEVQSNSCYQTMRDWMTLK 149
                 6678999***99996.5667799***********98888888887766655555 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.0051
                 HHHHHHHHTTHHHHHHHHHHHHHHHHTTT-GGGS-EEEESGGGGGGSS--SSHHHHHH CS
         MTD 136 dvlkvLaatGavRlvqeeldkviekvkagkeielPkividaekaveaaefsnPYakak 193
                 ++ ++L ++Ga + ++  + + + +v++ + i   +i++++e+a e+ +f+n + + k
  EFC39426.1 211 QIARILLECGACKKIDCLFSDDVIMVSEYSGIVRQRIMLNSEQAAERLQFTNLHQMIK 268
                 577999**********999888888999999999*****************9776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (307 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1970  (0.109878); expected 358.6 (0.02)
Passed bias filter:                      763  (0.0425568); expected 358.6 (0.02)
Passed Vit filter:                        86  (0.0047967); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 1792.98
//
Query:       EFC39427.1  [L=523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2390  (0.133304); expected 358.6 (0.02)
Passed bias filter:                      611  (0.0340789); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.79u 0.35s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 2851.25
//
Query:       EFC39428.1  [L=486]
Description: leucine-rich repeat, typical subtype-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.7e-27   93.1  46.4     0.0025   17.7   0.5   13.2 13  LRR_6       Leucine Rich repeat
    4.5e-13   49.1  48.5     0.0028   18.0   0.1    8.9  9  LRR_4       Leucine Rich repeats (2 copies)
    4.2e-08   32.7  34.9        1.1   10.0   0.3   11.7 12  LRR_1       Leucine Rich Repeat
     0.0038   17.0  49.4          3    7.7   6.4    9.1  8  LRR_8       Leucine rich repeat
     0.0099   15.8   0.0      0.022   14.7   0.0    1.6  1  F-box-like  F-box-like
  ------ inclusion threshold ------
       0.31   11.3   6.9        1.5    9.0   0.2    4.2  4  YjcQ        YjcQ protein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.1   5.4e-05      0.16       3      23 ..     100     120 ..      99     121 .. 0.89
   2 ?    3.1   0.0      0.04   1.2e+02       4      18 ..     128     142 ..     126     142 .. 0.88
   3 !   10.5   0.1   0.00018      0.53       3      19 ..     154     170 ..     152     170 .. 0.92
   4 !    7.3   0.1    0.0018       5.5       3      24 .]     181     202 ..     179     202 .. 0.87
   5 !    5.1   0.9    0.0092        27       2      15 ..     207     220 ..     206     229 .. 0.81
   6 !   10.1   0.0   0.00024       0.7       3      24 .]     235     256 ..     233     256 .. 0.88
   7 !   10.7   0.1   0.00015      0.46       3      24 .]     289     310 ..     288     310 .. 0.93
   8 ?    4.4   0.3     0.015        46       3      24 .]     316     337 ..     314     337 .. 0.90
   9 !   17.4   0.1   1.1e-06    0.0032       5      22 ..     343     360 ..     340     361 .. 0.90
  10 !   17.7   0.5   8.3e-07    0.0025       4      23 ..     369     388 ..     368     389 .. 0.91
  11 !   12.1   0.1   5.2e-05      0.16       3      24 .]     395     416 ..     394     416 .. 0.93
  12 !    7.2   0.0     0.002       6.1       3      24 .]     422     443 ..     421     443 .. 0.95
  13 ?   -0.8   0.2      0.73   2.2e+03       3      13 ..     449     459 ..     448     460 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 5.4e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt LdL+++ Ig eG++  
  EFC39428.1 100 RNLTGLDLNFCRIGLEGVKLV 120
                 68999*************976 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.04
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +L++L+L++ +I+ e
  EFC39428.1 128 KLKTLSLQWSEIDAE 142
                 7********999875 PP

  == domain 3  score: 10.5 bits;  conditional E-value: 0.00018
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                 + Lt LdL gN IgDeG
  EFC39428.1 154 SQLTDLDLYGNSIGDEG 170
                 579*************9 PP

  == domain 4  score: 7.3 bits;  conditional E-value: 0.0018
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                  +Lt L+L gN++  +G++ L+
  EFC39428.1 181 KNLTRLNLEGNGLEIAGIKHLS 202
                 58***********999988875 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.0092
       LRR_6   2 nthLteLdLsgNdI 15 
                  ++L+ L+L++N +
  EFC39428.1 207 MSNLRDLNLAHNSL 220
                 589*********86 PP

  == domain 6  score: 10.1 bits;  conditional E-value: 0.00024
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 t+Lt+LdLsg +I  +G++ ++
  EFC39428.1 235 TKLTYLDLSGSGIKLAGISTMC 256
                 79************99998765 PP

  == domain 7  score: 10.7 bits;  conditional E-value: 0.00015
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt+L+++g +I+ +G++ La
  EFC39428.1 289 NNLTSLNVKGSQITEKGMSFLA 310
                 69****************9987 PP

  == domain 8  score: 4.4 bits;  conditional E-value: 0.015
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 +++++L L+ N + D G+++L+
  EFC39428.1 316 QKVKSLILTRNLVLDGGLQSLS 337
                 789***************9996 PP

  == domain 9  score: 17.4 bits;  conditional E-value: 1.1e-06
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 +teLdLs N+I+D+G+  
  EFC39428.1 343 ITELDLSNNGISDKGVRH 360
                 79*************976 PP

  == domain 10  score: 17.7 bits;  conditional E-value: 8.3e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L+Ls NdI+++G++ L
  EFC39428.1 369 QLTNLNLSNNDITGKGVSTL 388
                 59***************987 PP

  == domain 11  score: 12.1 bits;  conditional E-value: 5.2e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L+ L+L+ N I +eGae ++
  EFC39428.1 395 SNLQVLNLNNNYIENEGAEHIS 416
                 68*****************986 PP

  == domain 12  score: 7.2 bits;  conditional E-value: 0.002
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L+ L+L+  +I+ eG++ +a
  EFC39428.1 422 RNLKRLELTASGISKEGLKHIA 443
                 68*****************997 PP

  == domain 13  score: -0.8 bits;  conditional E-value: 0.73
       LRR_6   3 thLteLdLsgN 13 
                 ++L +L+++ N
  EFC39428.1 449 SNLSYLNVARN 459
                 6899****999 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0011       3.3       2      30 ..     101     134 ..     100     146 .. 0.80
   2 !   18.0   0.1   9.3e-07    0.0028       2      36 ..     155     193 ..     154     200 .. 0.82
   3 !   12.9   6.1   3.9e-05      0.12       1      36 [.     181     221 ..     181     230 .. 0.76
   4 !    5.5   4.7    0.0082        25       1      32 [.     235     271 ..     235     330 .. 0.85
   5 !    6.8   1.1    0.0031       9.2      24      37 ..     342     354 ..     316     360 .. 0.54
   6 !   14.0   4.1   1.7e-05      0.05       3      40 ..     343     381 ..     341     382 .. 0.80
   7 !   17.0   8.8   1.9e-06    0.0057       2      38 ..     369     409 ..     368     414 .. 0.82
   8 !    8.1   3.5    0.0012       3.7       2      30 ..     396     429 ..     395     440 .. 0.63
   9 ?    2.1   0.2     0.095   2.8e+02      13      33 ..     442     459 ..     422     468 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0011
                 S--EEE--SS---E-S-..HH....H-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl..le....klpnLkeLdL 30 
                 nL+ LdL+ +++  +++  l      + +Lk+L+L
  EFC39428.1 101 NLTGLDLNFCRIG-LEGvkLVasheMMAKLKTLSL 134
                 9**********99.777663356757********9 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 9.3e-07
                 S--EEE--SS---E-S-..HH...H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLsgNnli 36 
                 +L+ LdL +N + d ++  ++    ++nL+ L+L gN  +
  EFC39428.1 155 QLTDLDLYGNSIGDEGSriISesiYMKNLTRLNLEGN-GL 193
                 69************99987225667*********999.55 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 3.9e-05
                 SS--EEE--SS---E-S-..HH...H-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..le...klpnLkeLdLsgNnli 36 
                 +nL+ L+L +N l   +   l+   ++ nL+ L+L +N+l+
  EFC39428.1 181 KNLTRLNLEGNGLEIAGIkhLSesqNMSNLRDLNLAHNSLL 221
                 79*********966333344446757*********999554 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.0082
                 SS--EEE--..SS---E-S-.HH..H-TT--EEE-.- CS
       LRR_4   1 pnLevLdLs..nNqltdipl.le..klpnLkeLdLsg 32 
                 ++L++LdLs  + +l  i+  ++  ++  Lk+L+L  
  EFC39428.1 235 TKLTYLDLSgsGIKLAGISTmCNssNMCGLKKLTLEK 271
                 79*******6557788888884454799999999933 PP

  == domain 5  score: 6.8 bits;  conditional E-value: 0.0031
                 T--EEE-.-S---- CS
       LRR_4  24 nLkeLdLsgNnlit 37 
                   +eLdLs+N  i+
  EFC39428.1 342 RITELDLSNN-GIS 354
                 4566666333.443 PP

  == domain 6  score: 14.0 bits;  conditional E-value: 1.7e-05
                 --EEE--SS---E-S-..HH..H.-TT--EEE-.-S-----GG CS
       LRR_4   3 LevLdLsnNqltdipl..le..k.lpnLkeLdLsgNnlitdld 40 
                  ++LdLsnN ++d +   +     + +L+ L+Ls+N    d++
  EFC39428.1 343 ITELDLSNNGISDKGVrhITtsAvFSQLTNLNLSNN----DIT 381
                 689*********966665226645*********999....886 PP

  == domain 7  score: 17.0 bits;  conditional E-value: 1.9e-06
                 S--EEE--SS---.E-S-..HH..H.-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqlt.dipl..le..k.lpnLkeLdLsgNnlitd 38 
                 +L++L+LsnN +t + +   l   k + nL++L+L +Nn+i++
  EFC39428.1 369 QLTNLNLSNNDITgK-GVstLVssKiISNLQVLNL-NNNYIEN 409
                 79***********44.4447336699*********.8889975 PP

  == domain 8  score: 8.1 bits;  conditional E-value: 0.0012
                 S--EEE--SS---E-S-..HH..H.-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl..le..k.lpnLkeLdL 30 
                 nL+vL+L+nN +   +   ++    + nLk L L
  EFC39428.1 396 NLQVLNLNNNYIENEGAehISksYlIRNLKRLEL 429
                 7888888888777555544114544666777766 PP

  == domain 9  score: 2.1 bits;  conditional E-value: 0.095
                 --E-S-HHH-TT--EEE-.-S CS
       LRR_4  13 ltdiplleklpnLkeLdLsgN 33 
                 + + p+   l nL +L++ +N
  EFC39428.1 442 IAESPF---LSNLSYLNVARN 459
                 444444...999****99887 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0      0.16   4.8e+02       1      12 [.     101     112 ..     101     121 .. 0.84
   2 ?    0.5   0.0      0.51   1.5e+03       1      12 [.     128     139 ..     128     150 .. 0.81
   3 ?    4.2   0.0     0.032        97       2      20 ..     156     174 ..     155     178 .. 0.78
   4 !    6.5   0.1    0.0056        17       1      13 [.     182     194 ..     182     204 .. 0.78
   5 !    6.1   1.4    0.0075        23       1      19 [.     209     231 ..     209     233 .. 0.78
   6 ?    3.1   0.2      0.07   2.1e+02       1      12 [.     236     247 ..     236     316 .. 0.79
   7 ?   -2.0   0.0       3.3   9.8e+03       2      20 ..     318     336 ..     317     338 .. 0.69
   8 !    6.7   0.0    0.0048        14       2      20 ..     343     361 ..     342     363 .. 0.87
   9 !    7.2   0.1    0.0031       9.3       2      20 ..     370     388 ..     369     390 .. 0.85
  10 !   10.0   0.3   0.00038       1.1       1      21 [.     396     416 ..     396     418 .. 0.89
  11 ?   -1.6   0.0       2.6   7.7e+03       1       8 [.     423     430 ..     423     441 .. 0.82
  12 ?   -1.2   0.0       1.8   5.4e+03       1      10 [.     450     459 ..     450     472 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+ LdL+ +++
  EFC39428.1 101 NLTGLDLNFCRI 112
                 7999******98 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.51
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L L +  +
  EFC39428.1 128 KLKTLSLQWSEI 139
                 7******99876 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.032
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ LdL +n++++ +++ +
  EFC39428.1 156 LTDLDLYGNSIGDEGSRII 174
                 889********77776654 PP

  == domain 4  score: 6.5 bits;  conditional E-value: 0.0056
       LRR_1   1 nLrhLdLsnnpll 13 
                 nL++L+L++n l+
  EFC39428.1 182 NLTRLNLEGNGLE 194
                 8*********984 PP

  == domain 5  score: 6.1 bits;  conditional E-value: 0.0075
       LRR_1   1 nLrhLdLsnnpl....lglppns 19 
                 nLr L+L +n+l    ++++ ns
  EFC39428.1 209 NLRDLNLAHNSLllegIQILCNS 231
                 8**********977666665555 PP

  == domain 6  score: 3.1 bits;  conditional E-value: 0.07
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++LdLs+  +
  EFC39428.1 236 KLTYLDLSGSGI 247
                 688888887654 PP

  == domain 7  score: -2.0 bits;  conditional E-value: 3.3
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                  ++L L++n  l+ + +s+
  EFC39428.1 318 VKSLILTRNLVLDGGLQSL 336
                 5889999998766665555 PP

  == domain 8  score: 6.7 bits;  conditional E-value: 0.0048
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                  ++LdLsnn +++++ +++
  EFC39428.1 343 ITELDLSNNGISDKGVRHI 361
                 579********99998886 PP

  == domain 9  score: 7.2 bits;  conditional E-value: 0.0031
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ L+Lsnn ++g++ +++
  EFC39428.1 370 LTNLNLSNNDITGKGVSTL 388
                 899********99988765 PP

  == domain 10  score: 10.0 bits;  conditional E-value: 0.00038
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++L+L+nn +++ ++++++
  EFC39428.1 396 NLQVLNLNNNYIENEGAEHIS 416
                 8***********998888876 PP

  == domain 11  score: -1.6 bits;  conditional E-value: 2.6
       LRR_1   1 nLrhLdLs 8  
                 nL++L L+
  EFC39428.1 423 NLKRLELT 430
                 89***995 PP

  == domain 12  score: -1.2 bits;  conditional E-value: 1.8
       LRR_1   1 nLrhLdLsnn 10 
                 nL +L++ +n
  EFC39428.1 450 NLSYLNVARN 459
                 7999998776 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.19   5.7e+02       1      32 [.     100     134 ..     100     141 .. 0.65
   2 !    6.2   1.5    0.0029       8.7      24      61 .]     153     193 ..     127     193 .. 0.76
   3 !    7.7   6.4     0.001         3       2      37 ..     182     220 ..     181     222 .. 0.62
   4 ?    1.4   0.0     0.093   2.8e+02      49      59 ..     235     245 ..     231     251 .. 0.70
   5 ?    2.5   6.2     0.041   1.2e+02       2      61 .]     290     353 ..     289     353 .. 0.59
   6 !    6.2   8.1    0.0028       8.4       2      61 .]     317     380 ..     316     380 .. 0.82
   7 !    7.0  10.4    0.0016       4.9       1      38 [.     368     408 ..     368     429 .. 0.86
   8 ?    3.4   0.4     0.022        66       2      36 ..     423     460 ..     422     463 .. 0.58

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.19
                 TT-SEEE-TTS-..-SEE-TTSSTT.-TT--EEE- CS
       LRR_8   1 pnLtsLdLsnNr..ltslddeaFkg.lsnLkvLdL 32 
                 +nLt LdL++ r  l++++  a +  + +Lk+L+L
  EFC39428.1 100 RNLTGLDLNFCRigLEGVKLVASHEmMAKLKTLSL 134
                 57777888777755566666666666667777766 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0029
                 -TT--EEE--SS--.....-GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNll.....ttlspgafsgLpsLrsLdLsgNrL 61 
                 +s+L+ LdL  N++     + +s      +++L+ L+L+gN L
  EFC39428.1 153 MSQLTDLDLYGNSIgdegsRIIS--ESIYMKNLTRLNLEGNGL 193
                 67888889988888444422333..556799999999999976 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.001
                 T-SEEE-TTS-..-SEE-TTSSTT.-TT--EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNr..ltslddeaFkg.lsnLkvLdLsnNll 37 
                 nLt+L+L  N   + +++  + ++ +snL+ L+L +N+l
  EFC39428.1 182 NLTRLNLEGNGleIAGIKHLSESQnMSNLRDLNLAHNSL 220
                 677777777764445555555544577777777777765 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.093
                 -S-.EEE--SS CS
       LRR_8  49 psLrsLdLsgN 59 
                 ++L++LdLsg 
  EFC39428.1 235 TKLTYLDLSGS 245
                 46666666664 PP

  == domain 5  score: 2.5 bits;  conditional E-value: 0.041
                 T-SEEE-TTS--SEE-TTSS...TT-TT--EEE--SS.---GGGGGGGTT--.S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaF...kglsnLkvLdLsnN.llttlspgafsgLp.sLrsLdLsgNrL 61 
                 nLtsL++  +++t+ + ++    ++l+++k+L L++N  l+    +++s  + ++++LdLs+N +
  EFC39428.1 290 NLTSLNVKGSQITEKGMSFLassTNLQKVKSLILTRNlVLDG-GLQSLSKSTlRITELDLSNNGI 353
                 677777777777777776551114577888888888844444.2333333222788888888865 PP

  == domain 6  score: 6.2 bits;  conditional E-value: 0.0028
                 T-SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---GGGGG...GGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNllttlspg...afsgLpsLrsLdLsgNrL 61 
                 +++sL+L++N  l +  ++  k+  + ++LdLsnN ++    +   + + +++L+ L+Ls+N++
  EFC39428.1 317 KVKSLILTRNLvLDGGLQSLSKSTLRITELDLSNNGISDKGVRhitTSAVFSQLTNLNLSNNDI 380
                 6899*******88888888888899***********99876651114566899*********97 PP

  == domain 7  score: 7.0 bits;  conditional E-value: 0.0016
                 TT-SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS--- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkg...lsnLkvLdLsnNllt 38 
                 ++Lt+L+LsnN +t+ + ++  +    snL+vL+L+nN ++
  EFC39428.1 368 SQLTNLNLSNNDITGKGVSTLVSskiISNLQVLNLNNNYIE 408
                 58************98888887645689**********997 PP

  == domain 8  score: 3.4 bits;  conditional E-value: 0.022
                 T-SEEE-TTS--.....SEE-TTSSTT-TT--EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrl.....tslddeaFkglsnLkvLdLsnNl 36 
                 nL++L L+ + +     +++  + F  lsnL +L+  +N 
  EFC39428.1 423 NLKRLELTASGIskeglKHIAESPF--LSNLSYLNVARNV 460
                 5666666555431100045555555..5999999999995 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0   7.3e-06     0.022       9      43 ..      44      80 ..      41      82 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 7.3e-06
  F-box-like  9 LlqIFsyLppsdLlr.lalVCrrWrrvaldt.plLWr 43
                L +I+ +Lp++d+l   +lV+ +W rv+ +  p +W+
  EFC39428.1 44 LHEILTFLPFQDILHkYMLVSVQWMRVVMKSvPIFWH 80
                789*********99989***********665588887 PP

>> YjcQ  YjcQ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.4   4.3e+03      67      87 ..     110     130 ..     103     135 .. 0.84
   2 ?    2.7   0.1     0.051   1.5e+02      58      81 ..     263     286 ..     246     293 .. 0.75
   3 ?    9.0   0.2   0.00052       1.5      60      89 ..     292     321 ..     285     324 .. 0.85
   4 ?   -0.3   0.2      0.42   1.2e+03      55      77 ..     393     415 ..     344     447 .. 0.69

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.4
                 -EE-HHHHHHHHHHT-S---X CS
        YjcQ  67 vritlkGleyLkeNsmmkKal 87 
                  ri l+G++  ++  mm+K +
  EFC39428.1 110 CRIGLEGVKLVASHEMMAKLK 130
                 689999999999999999976 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.051
                 .SEE--SS--EE-HHHHHHHHHHT CS
        YjcQ  58 geivisidnvritlkGleyLkeNs 81 
                 g   + ++++ i + G++yL+e  
  EFC39428.1 263 GLKKLTLEKIDIGEGGMQYLAESN 286
                 566788999***********9965 PP

  == domain 3  score: 9.0 bits;  conditional E-value: 0.00052
                 EE--SS--EE-HHHHHHHHHHT-S---XXX CS
        YjcQ  60 ivisidnvritlkGleyLkeNsmmkKalka 89 
                  +++++ ++it+kG+ +L++ + ++K++ +
  EFC39428.1 292 TSLNVKGSQITEKGMSFLASSTNLQKVKSL 321
                 6788999*******************9865 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.42
                 S...SEE--SS--EE-HHHHHHH CS
        YjcQ  55 tkkgeivisidnvritlkGleyL 77 
                 ++++  v++++n +i  +G e++
  EFC39428.1 393 IISNLQVLNLNNNYIENEGAEHI 415
                 23345556666666666666654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       438  (0.0244297); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.69u 0.32s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 2740.73
//
Query:       EFC39429.1  [L=360]
Description: asparaginase family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-77  260.9   0.3    3.4e-69  233.2   0.2    2.0  2  Asparaginase_2   Asparaginase
    0.00037   19.4   0.0    0.00054   18.9   0.0    1.2  1  G_glu_transpept  Gamma-glutamyltranspeptidase
  ------ inclusion threshold ------
      0.093   12.4   0.1         26    4.5   0.1    2.9  3  Thiolase_C       Thiolase, C-terminal domain
        6.5    6.7   7.8         51    3.9   0.3    3.7  4  DUF5633          Family of unknown function (DUF5633)


Domain annotation for each model (and alignments):
>> Asparaginase_2  Asparaginase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  233.2   0.2   7.6e-73   3.4e-69       1     245 [.       9     262 ..       9     286 .. 0.85
   2 !   26.1   0.0   8.6e-10   3.9e-06     250     300 ..     292     342 ..     271     347 .. 0.89

  Alignments for each domain:
  == domain 1  score: 233.2 bits;  conditional E-value: 7.6e-73
                     -EEEEEEEEESE-G-HHHHHHHHHCHHHHHHHHHHHHHTT-.-HHHHHHHHHHHHHCTCCCSSSTTSS-BTTS---EEEEEEETTTTEEEEEEEE CS
  Asparaginase_2   1 pvlvihGGAgsilktkereeavrkalkealeagykvLkegg.saldaVeaavrllEddplfnaGkGsvltedgeveldAsimdgktlraGaVagv 94 
                     p +++hGGA+si+k  + e++  ++ ++a++++y +L +g+  a +a ++a+++lE+d  f+aGkGs l+ +g+ve+dAsim+g++l++GaV+g+
      EFC39429.1   9 PLMIVHGGAWSIPK--DLEQDHIDGTRSAIANVYPALLKGEiDAEEAAVRAIKILENDETFDAGKGSFLNLKGQVEMDASIMNGTSLKSGAVCGI 101
                     579***********..99999*************999886538999************************************************* PP

                     SSBS-HHHHHHHHHHHCS-SEEEHHHHHHHH........HHTT-----CGGG--HHHHHHHHHHHHCCCHS..B-S-BS-TTT...........T CS
  Asparaginase_2  95 krvknpislArlvmeksehvlLvgegAeefa........reqglelvdeesllteerlkelekakkekaekkeaknvsekelk...........a 170
                     + v+npi +Ar+vm+++eh lLvge A efa        + ++l + + e+llt+++l+ l++++++++ ++          +           +
      EFC39429.1 102 QGVRNPICVARMVMNRTEHNLLVGENALEFAksnlktdeERKELLIESVEELLTKRELEFLDRIRNNEEFTSR---------TvfeakdtqpppS 187
                     *******************************555555443344444566667777777777776665544332.........122223334678* PP

                     T---EEEEEE-TTS-EEEEEEE--STTB-TTEE-STTSTTTSEEEETTTEEEEEEE-HHHHCCTTHHHHHHHHHH CS
  Asparaginase_2 171 klgTvGaValDsegnlAaaTSTgGltnklvGRvGDspiiGaGtYAdnkvgAvsaTGkGeeiirellaadivalme 245
                     k+gTvG+V+lD++gn+ aaTSTgG+  k++GR GD+ +iG+Gt+Ad++v+++s+TG+Ge+i+ + ++ + +  +e
      EFC39429.1 188 KRGTVGVVVLDRNGNICAATSTGGTPKKVPGRSGDTGLIGSGTFADSSVAGASSTGWGESIMTIQMTGTLIRWLE 262
                     **************************************************************9998877666555 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 8.6e-10
                     -HHHHHHHHHHCHHHHTTT-EEEEEEETTS-EEEEECSCCCEEEEEETTS- CS
  Asparaginase_2 250 sleeAaekvieeklkrvkgsgGviavdkkGevaaefnsegmlrayakedel 300
                     +++ A+++vie+ +++v+g gG+i+++k+G++a+++n+ +m+ ay+ +d++
      EFC39429.1 292 QVNLATQRVIEYLQEKVNGLGGLIVLSKDGKYAVSHNTDKMSFAYVPADSV 342
                     6778*****************************************988765 PP

>> G_glu_transpept  Gamma-glutamyltranspeptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.0   1.2e-07   0.00054     277     350 ..     138     212 ..     115     226 .. 0.84

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 1.2e-07
                      SSTTTSSSGHCHHHHHT-HHHHHHHHTT.BTTB..SGGGCSCGGCSCG...TTEEEEEEEEETTS-EEEEEEEESS CS
  G_glu_transpept 277 gDpdfvknptelveellskeyakeraklIkdkaatpsseyykaaeaaee..sggTthlsvvDregnaVSltstinl 350
                      +D +  +   e+veell k+ ++   ++I+++++++s ++ +a++++++  + gT+ + v+Dr+gn+ ++tst ++
       EFC39429.1 138 TDEERKELLIESVEELLTKRELEF-LDRIRNNEEFTSRTVFEAKDTQPPpsKRGTVGVVVLDRNGNICAATSTGGT 212
                      566666666799*******99987.678*****99998888888777776799********************875 PP

>> Thiolase_C  Thiolase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1    0.0057        26      32      98 ..      48     115 ..      30     125 .. 0.76
   2 ?   -2.2   0.0      0.69   3.1e+03      40      65 ..     160     185 ..     148     193 .. 0.72
   3 ?    4.4   0.0    0.0062        28      45      78 ..     284     317 ..     271     320 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0057
                 HHHHT--GGGESEEEE--SBHH...HHHHHHHHHT--GGGBSTT--HHHH-B-TTTHHHHHHHHHHHHHH CS
  Thiolase_C  32 lkkagltvedidlfEinEAFaa...qaLavakaldldlekvNvnGGaialGHPlGasGaRivvtllselk 98 
                 ++ ++  v+ i ++E +E F a    +L    ++++d++ +N  G ++  G   G+ G+R  + +++ + 
  EFC39429.1  48 IDAEEAAVRAIKILENDETFDAgkgSFLNLKGQVEMDASIMN--GTSLKSGAVCGIQGVRNPICVARMVM 115
                 56677789999*******997533257888888888888765..99999999999999998777766544 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.69
                 GGESEEEE--SBHHHHHHHHHHHT-- CS
  Thiolase_C  40 edidlfEinEAFaaqaLavakaldld 65 
                 e +d +  nE F++ ++  ak+ +  
  EFC39429.1 160 EFLDRIRNNEEFTSRTVFEAKDTQPP 185
                 44788899999999999888887655 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.0062
                 EEE--SBHHHHHHHHHHHT--GGGBSTT--HHHH CS
  Thiolase_C  45 fEinEAFaaqaLavakaldldlekvNvnGGaial 78 
                  E +E   ++ La+++ +++ +ekvN  GG i l
  EFC39429.1 284 QEKQEPLEQVNLATQRVIEYLQEKVNGLGGLIVL 317
                 57788888999*******************9976 PP

>> DUF5633  Family of unknown function (DUF5633)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.6      0.02        90       6      18 ..      47      59 ..      45      66 .. 0.80
   2 ?    3.9   0.3     0.011        51       7      21 ..     126     140 ..     125     143 .. 0.92
   3 ?   -3.3   0.0       1.9   8.6e+03      31      36 ..     318     323 ..     315     323 .. 0.80
   4 ?    1.6   0.0     0.058   2.6e+02      20      29 ..     343     352 ..     340     354 .. 0.88

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.02
     DUF5633  6 keeAekAAkkALe 18
                +++Ae+AA  A++
  EFC39429.1 47 EIDAEEAAVRAIK 59
                5799****99997 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.011
     DUF5633   7 eeAekAAkkALendp 21 
                 e+A + Ak +L++d+
  EFC39429.1 126 ENALEFAKSNLKTDE 140
                 89***********96 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 1.9
     DUF5633  31 gadGry 36 
                  +dG+y
  EFC39429.1 318 SKDGKY 323
                 69***9 PP

  == domain 4  score: 1.6 bits;  conditional E-value: 0.058
     DUF5633  20 dpiNnsYeva 29 
                 d +Nn +ev+
  EFC39429.1 343 DLVNNTFEVV 352
                 99******96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (360 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       623  (0.0347482); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2064.12
//
Query:       EFC39430.1  [L=568]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-60  205.5   0.8      2e-60  204.9   0.8    1.3  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  204.9   0.8   1.1e-64     2e-60       2     459 ..      87     553 ..      86     557 .. 0.89

  Alignments for each domain:
  == domain 1  score: 204.9 bits;  conditional E-value: 1.1e-64
                 -SESEHHCCHCHHHHTT.TCCHHHHHHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGH.HHHHHH CS
        p450   2 pgptplplvgnllqlgr.keelhevlrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfang.ekwkkl 98 
                 pgp+plpl+gn l +++   + +e++ +l k+yg++++l   + + v+ls+p+++  v   +     +++  +  ++ + + ++   + ++  e w  +
  EFC39430.1  87 PGPKPLPLLGNYLDIKKnATNTQEFFLDLCKEYGEMVKLTAFGVNLVILSDPSLIADVARVEE---RRTILGPSRYYKQTRGLELVPVEMKIeENWNDI 182
                 8999*************999*****************************************95...333344444443445555556666668****** PP

                 HHHHHHHHTSH.STTTHHHHHHHHHHHHHHHHHCCCCHCS.....EEETHHHHHHHHHHHHHHHHHSSHHHT.TTSSHHHHHHHHHHHHHHHHHCHHHH CS
        p450  99 Rrfltptltsf.gklsleelveeeaedlveklrkkagess.....elditellskaaldvigsilFgarfdl.ledeklselvkaveelssllskssvq 190
                 R++++ ++      + +++ ++e+++d +++lrk+ ++ +       +  e  s++a+d+i++++Fg+++   le   + +l+++ ++ +++l     +
  EFC39430.1 183 RQIFNLAMKPEfLDRIVVPQLTEMNSDYIRQLRKNFTKVGenkyrLNNGMEATSRYAFDAIMKVFFGVKMTEeLERGLPFKLDDFSKQAMTVL-DLCSR 280
                 *********99888899****************98777776769889999******************98621444447799*******9999.55669 PP

                 CCCCCHHHTCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHCHCHCSCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
        p450 191 llllfpllkylptkllrklkeavkklkdlldklieerretldsakksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeL 289
                 l+   p++ky+ tk +  ++++ + ++  ++ ++    + l +   s+  fl +l + +   +g  +  ++ +++ + ++l +Gvd ts  + ++Ly L
  EFC39430.1 281 LDYKLPIYKYFKTKEYGIIENMYDSVIANTRYCVDRFGQPLPEG--SKPRFLEILTQRS---EGI-ENAQDKVTTVLSTFLQGGVDLTSRISNFILYRL 373
                 999999**************************************..9***********7...444.5688999999*********************** PP

                 HHSHHHHHHHHHHHHHHCCTTT..........T-HHHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSS CS
        p450 290 aknPevqeklreEidevlgdkr..........eptyddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfp 378
                 a++Pe+qek+++E  e++g+            e+t ++ +kl++++++++E+ R+ ++++++  R++ +d++i+g+++pk t+vi++ y  ++ +e+ p
  EFC39430.1 374 AHHPEYQEKIYQECLEIFGEPTeneilsenglEITPEQYKKLKLTKQFVEEVTRFNSFAYITFGRQLNTDLEIGGFNLPKETVVIFMNYFPSMKDEYVP 472
                 ******************776679*********************************************************************99999* PP

                 STTS--GGGGB-TTSCTESSCTT--TTEEGGGS-TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSCSSEEESSSS CS
        p450 379 nPeeFdpeRFldekgnskrksfaflPFGaGpRnCiGerlArmelklflatlLqnFevelqpetdpppileksglllppkpi 459
                 n+ eF peR ++++    ++ f++lPFG G+R C+G r+A  e +  +++ ++nF+++  + + p++  ++  + + +k++
  EFC39430.1 473 NALEFIPERHDKKSPLAPKSMFSSLPFGVGARKCPGSRIANAEFHFSIINAVRNFKLTKEHAEFPKMETDQITFYISTKKY 553
                 ***************899****************************************75544444444443666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (568 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       438  (0.0244297); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.34s 00:00:01.05 Elapsed: 00:00:00.54
# Mc/sec: 3164.66
//
Query:       EFC39431.1  [L=495]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-30  105.8   0.0    4.3e-30  104.4   0.0    1.8  1  Ras       Ras family
    5.3e-18   65.3   4.5    2.6e-13   50.2   0.3    3.5  3  BTB       BTB/POZ domain
    1.1e-11   45.0   0.0    3.2e-11   43.5   0.0    1.8  1  Roc       Ras of Complex, Roc, domain of DAPkinase


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.4   0.0   7.2e-34   4.3e-30       1     159 [.       6     162 ..       6     165 .. 0.90

  Alignments for each domain:
  == domain 1  score: 104.4 bits;  conditional E-value: 7.2e-34
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 Klv+vGds vGK++ll+  ++++F+e+y +T+   f + ++ + ++++++ +wDT    ++++lr l+y  ++++++++++ +r sfenv+ kw+ e+ 
  EFC39431.1   6 KLVVVGDSKVGKSCLLIASTTNSFPEDYAPTV---FDSVNVIYGNRNYNVGLWDT----DYDRLRALSYLRTDVFFVCFSMVDRISFENVEsKWIPELI 97 
                 99******************************...7778999*************....8*******************************9******* PP

                 HHSTTTSEEEEEEETTTGGG....G-SS-HHHH.HHHHHHHTSEEEEEBTTTTCTHHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee....kravsteeg.eelakelglkfletSAktnenveeafeellre 159
                 ++++ ++pi+LvG K+Dl +    +  v++e   ++l ++l    + tS +  +n++++f+ +++e
  EFC39431.1  98 HHCP-DIPIILVGCKSDLVSnadcDSIVTKEMIeQKLQNSLASLCIITSSRAMYNIDKLFKLAISE 162
                 ****.5************997777666666655145666777888999************988765 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.6   0.2   4.1e-05      0.24       1      44 [.     212     261 ..     212     285 .. 0.81
   2 ?    3.5   0.0     0.014        84      57      97 ..     311     356 ..     288     370 .. 0.70
   3 !   50.2   0.3   4.4e-17   2.6e-13       2      94 ..     391     490 ..     390     492 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4.1e-05
                 HHHHHHHTTTS-EEEEETT.....TEEEEE-HHHHHHH.-HHHHHHHTST CS
         BTB   1 lnelresgelcDvtlvvgd.....gkefkahkavLaar.SpyFkalftsk 44 
                 +++l++s+  cD  +v+ +     + e+kah +vLa+  S++  +lf + 
  EFC39431.1 212 FKNLLDSDFCCDTKFVIYNskkdiDVEIKAHSLVLACVpSKVIGKLFDEV 261
                 68899999***********9999************975599999999876 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.014
                 TTSGHHHHHHHHHHHHHSEEEC-.....CGGGHHHHHHHHHHHT-H CS
         BTB  57 ddvepeafealLefiYtgeleit.....seenleelLaaadllqip 97 
                 + ++++af++lLe+ Y g  e+      +++ l+++ +a  +l+++
  EFC39431.1 311 NTIHHRAFKSLLEIQYYGGSETMrkrckKDQFLNKVKTASTILECE 356
                 678999*********9997777665554444444444444566555 PP

  == domain 3  score: 50.2 bits;  conditional E-value: 4.4e-17
                 HHHHHHTTTS-EEEEETT...TEEEEE-HHHHHHH-HHHHHHHTST..TTTTCCCE......EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHH CS
         BTB   2 nelresgelcDvtlvvgd...gkefkahkavLaarSpyFkalftsk..eieessvs......eielddvepeafealLefiYtgeleitseenleelLa 89 
                 ++++++++ +Dv +v+ +    k f+ hk++L+a  ++F+++f+ +  e   +s+       ei  ++   ++f+al+e++Y+++ +i+ e n++ lL+
  EFC39431.1 391 KKYFDKKTHSDVEIVFSTtdsSKNFHGHKLFLSANCDVFRTMFEANfvE---HSSRqvdlsgEIGENENRISEFHALFEYLYSAHSTIN-ERNAVGLLS 485
                 5789999*********999999************************553...443334588999999*********************7.********* PP

                 HHHHH CS
         BTB  90 aadll 94 
                 +a+ +
  EFC39431.1 486 LANEY 490
                 **988 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.5   0.0   5.3e-15   3.2e-11       1     119 [.       6     113 ..       6     114 .. 0.79

  Alignments for each domain:
  == domain 1  score: 43.5 bits;  conditional E-value: 5.3e-15
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEE..EEEGHHHHCHH. CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalail..vydsrssenlk. 96 
                 K+v+vGds+vGK++ll   ++++f e++ +t+  ++    v  i g  n    +++++ +WDt   +r r+l  +ylr +  +++  ++d+ s+en++ 
  EFC39431.1   6 KLVVVGDSKVGKSCLLIASTTNSFPEDYAPTVFDSVN---V--IYG--N----RNYNVGLWDTD-YDRLRAL--SYLRTDVFFVCfsMVDRISFENVEs 90 
                 99*****************************976663...3..334..2....45889****95.4566666..5666655554422567779999953 PP

                 HHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  97 eWlkelkkvagkspvilvgnkiD 119
                 +W+ el ++++++p+ilvg k D
  EFC39431.1  91 KWIPELIHHCPDIPIILVGCKSD 113
                 7********************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (495 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       664  (0.037035); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 2926.42
//
Query:       EFC39432.1  [L=448]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.048   11.8   5.7      0.077   11.1   5.7    1.3  1  AF-4      AF-4 proto-oncoprotein


Domain annotation for each model (and alignments):
>> AF-4  AF-4 proto-oncoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   5.7   4.3e-06     0.077     411     489 ..     367     448 .]     353     448 .] 0.65

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 4.3e-06
        AF-4 411 skkvstsqqsk.smLeddLklsssedsdeeqapekpksss..apssapqstpesvesahsssaeSeSsSeSeSSSeSDSesE 489
                 sk  ++ + +k s L+  L++  +e +d+ ++ ++++  +    ++a+ ++p+s  + +s++ +    SeSeS SeS+SesE
  EFC39432.1 367 SKAQKRDRRNKmSALKKCLNILYDERDDDLKTKSQSRLDEiiVGAEANWEIPQSAYNPKSKKRKVVAESESESESESESESE 448
                 34444444444599*********99999876666555544113445566677777777777777777777777766777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (448 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       705  (0.0393218); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2760.78
//
Query:       EFC39433.1  [L=348]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.2e-11   43.6   0.3    5.6e-11   42.8   0.3    1.4  1  TLD       TLD
  ------ inclusion threshold ------
      0.071   13.6   0.5       0.12   12.8   0.5    1.3  1  ZapB      Cell division protein ZapB
       0.76    9.8   4.9        1.3    9.0   4.9    1.3  1  FlxA      FlxA-like protein


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.8   0.3   9.4e-15   5.6e-11       1     137 [.     195     347 ..     195     348 .] 0.74

  Alignments for each domain:
  == domain 1  score: 42.8 bits;  conditional E-value: 9.4e-15
         TLD   1 llyssskdgss.....lstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl.....spkfkvykstgknkaylntssdglgf 89 
                 ll++ss+dg+s     l ++  ++ nkgpt ++++ + + ifGa++sq+++ ++   + d+ +flfs+     +++f  + ++ + + +l +s+++l+f
  EFC39433.1 195 LLFRSSRDGFScvasvLANFQTRVSNKGPTFVIFQATSGAIFGAYTSQSLTTACT-QVTDTATFLFSIqsntgEQRFTKLLPQVTTNSVLPCSNQYLAF 292
                 6899999998833333456888888*************************86666.9999*********99998888888888888999999999**** PP

         TLD  90 GggqpkfsLwidsslekgtsrhs........etfengllsg......aseerfkikdiEVWg 137
                 G g   ++L+    +   + r+         + + +    g      ++ + f+++d+EV++
  EFC39433.1 293 GRG---YDLFYGCWVGVVVGRTVpntfpnmgQYYLS----GsgvaysTTGSAFDVTDFEVYS 347
                 *85...666655555544444444122222244443....2555577889999999999997 PP

>> ZapB  Cell division protein ZapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.5   2.1e-05      0.12      18      69 ..      43      96 ..      39      97 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 2.1e-05
        ZapB 18 dtitlLqmeieeLkeeneelkeenreleeeneqlk..eereawqerlkkLLgkl 69
                d +t+Lq e + L+ ++++l++ ++ l+ +n+     + r+a+ +++kk L+ l
  EFC39433.1 43 DWLTSLQSEASSLQVKVNQLEKVIALLTDSNSTISivQVRAAQLAKIKKSLDML 96
                66899***********************99999888899********9988876 PP

>> FlxA  FlxA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   4.9   0.00022       1.3       3      71 ..      34     106 ..      27     112 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00022
        FlxA   3 sssassssss..sgsasqiasLqkQiknlqkqLkelses.deltkeekk.kqqqliqaQIqqlqaQIaqlqqq 71 
                 ss+++ss ++  ++ +s+ +sLq  +++l+k +  l++s ++ +  + + +q   i++ +++l+ +I+ + q 
  EFC39433.1  34 SSTTGSSLRDwlTSLQSEASSLQVKVNQLEKVIALLTDSnSTISIVQVRaAQLAKIKKSLDMLNLEIQTINQA 106
                 22222222223356677778888888888888888888866777766667999***************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (348 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1113  (0.0620782); expected 358.6 (0.02)
Passed bias filter:                      564  (0.0314574); expected 358.6 (0.02)
Passed Vit filter:                        68  (0.00379274); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.48
# Mc/sec: 2172.42
//
Query:       EFC39434.1  [L=244]
Description: abl-interactor [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.06   13.7   3.1      0.088   13.2   1.6    2.1  2  E2F_CC-MB  E2F transcription factor CC-MB domain


Domain annotation for each model (and alignments):
>> E2F_CC-MB  E2F transcription factor CC-MB domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   1.6   4.9e-06     0.088       3      37 ..      17      53 ..      15      91 .. 0.76
   2 ?   -0.3   0.1      0.08   1.4e+03      49      49 ..     115     115 ..      67     162 .. 0.49

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.9e-06
   E2F_CC-MB  3 qelesleeeeqkLDelieklteqlknl.tedeknq.l 37
                +e+++l++ eqk+ ++i++++++ +n  +e++ ++  
  EFC39434.1 17 EEIAKLDQTEQKIGDIINWCSHNYQNSdKEQTYEKtK 53
                79***********************994444444343 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.08
   E2F_CC-MB  49 a 49 
                 +
  EFC39434.1 115 H 115
                 0 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1058  (0.0590105); expected 358.6 (0.02)
Passed bias filter:                      575  (0.0320709); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.27s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 1657.54
//
Query:       EFC39435.1  [L=808]
Description: zf-GRF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    4.1e-21   74.8  26.4      2e-12   47.0   2.9    3.0  3  zf-GRF       GRF zinc finger
  ------ inclusion threshold ------
      0.012   15.5   0.1      0.027   14.3   0.1    1.6  1  F-box-like   F-box-like
      0.029   13.8  21.6      0.045   13.2  21.6    1.3  1  SDA1         SDA1


Domain annotation for each model (and alignments):
>> zf-GRF  GRF zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.0   2.9   3.3e-16     2e-12       1      44 [.      10      52 ..      10      53 .. 0.88
   2 !   38.2   9.7   1.8e-13   1.1e-09       2      43 ..     113     157 ..     112     158 .. 0.93
   3 ?   -4.2   0.3         3   1.8e+04      25      30 ..     311     316 ..     310     320 .. 0.74

  Alignments for each domain:
  == domain 1  score: 47.0 bits;  conditional E-value: 3.3e-16
      zf-GRF  1 plCkcg.rl.avlltvrktgpNkGRkFYkCpkgkekqCgFFkWade 44
                p Ckc  r+ +vl+tv k+gpNkGR+FY+C+k +   C FF+W+++
  EFC39435.1 10 PPCKCAaRPaSVLRTVVKEGPNKGRQFYTCAKSS---CKFFEWVNT 52
                67***986625789*****************999...******997 PP

  == domain 2  score: 38.2 bits;  conditional E-value: 1.8e-13
      zf-GRF   2 lCk.cg.rlavlltvrktgpNkGRkFYkCpkgke.kqCgFFkWad 43 
                  C+ ++ + ++ll v+k+gpNkG+ F++C + ++ ++C+FFkW d
  EFC39435.1 113 CCTnHQtTKCKLLQVSKEGPNKGKLFWACGNTNQsEKCNFFKWFD 157
                 68879999*********************99999899******88 PP

  == domain 3  score: -4.2 bits;  conditional E-value: 3
      zf-GRF  25 FYkCpk 30 
                 FY C  
  EFC39435.1 311 FYNCKS 316
                 9**976 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.1   4.6e-06     0.027       2      35 ..     210     244 ..     209     247 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 4.6e-06
  F-box-like   2 srLPdEiLlqIFsyLpps.dLlrlalVCrrWrrva 35 
                 ++LP E  ++I+ yL    d + + +VC  W+r+ 
  EFC39435.1 210 ANLPVETFSEILKYLQIApDCVKIQRVCVEWKRMS 244
                 68*************6555************9975 PP

>> SDA1  SDA1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2  21.6   7.5e-06     0.045      99     183 ..     724     801 ..     647     808 .] 0.61

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 7.5e-06
        SDA1  99 ddeedwevesdddseedseggwidvesdeeeieesdesedeeeeeeeeeekeekeeeeeeeeeeeeeeeeeeeeeekekkkkkak 183
                  d e++++e++dds e++++++ + ++++ + +++d +e ee+++ +e+++ee+eeeee++ +   +++++ ++++k+++   a+
  EFC39435.1 724 GDYEEEDEEDEDDS-EEENDNFFNFQNNNSDLSSEDGNEPEEDDDYQESNEEEEEEEEESDYS---DDSDSGKKRKKKTR---AT 801
                 22233333333444.455566999998888888888888887777666666655555555422...22222222111111...11 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (808 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1678  (0.0935914); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        23  (0.00128284); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.68u 0.26s 00:00:00.94 Elapsed: 00:00:00.43
# Mc/sec: 5691.18
//
Query:       EFC39436.1  [L=707]
Description: membrane bound adenylate/guanylate cyclase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.2e-23   83.4   0.0    4.7e-23   82.9   0.0    1.2  1  NIT            Nitrate and nitrite sensing
    5.2e-21   75.1   0.0    1.1e-20   74.0   0.0    1.4  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> NIT  Nitrate and nitrite sensing
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   82.9   0.0   5.2e-27   4.7e-23       2     226 ..     124     367 ..     123     370 .. 0.80

  Alignments for each domain:
  == domain 1  score: 82.9 bits;  conditional E-value: 5.2e-27
         NIT   2 LvhaLQkERglsagylasgggerkaaelaaqraatDaalaalr...........alaglarrldallrald.......qLpalRrqv.dtrkldakeav 81 
                 +v++LQ+ERg +a+yl+s + ++   +la++r++tD a+++++           + ++ +r+   + + l        +++++R +v d ++ ++ +++
  EFC39436.1 124 IVNSLQNERGTTALYLGSHK-RQYIIQLAKARNQTDIAIERFLalsvspndiliN-EKWKRTWYLFEDYLGkvtnyskGIGEWRMKVeDVTNETFLPTF 220
                 799**************974.466666**************98888888887662.333444444444442233445699*******997766667776 PP

         NIT  82 aaYtdviaaLldladelaqgspdrelarqlralaalsrakEalsqerallaaalaagrfsaalyaaflslvarqqaalaefraaatpaqralydetv.t 179
                 +  +d ++   dl++ ++++s d++ a   ++++ l + kE+ ++ r l++ ++ +g++s+++ ++f +++ r +++   f+  a+ +  + + + v +
  EFC39436.1 221 QIVSDWNSLTNDLIRVITSQSLDPTFAIIHNSFNLLTSTKEYRGIRRFLGTFGFLNGSLSQSSINSFKEAAIRGRLLRHLFSLQASNDIYEEFHSNVlS 319
                 66666666666666666667778**************************************************99999***999999988888888856 PP

         NIT 180 gpavkaaetlrdr.lastggvdaed....e.eeWfaastaridqlravesrla 226
                 +   +  ++++d  la     + ++    + +eW++++t  +d  r+ve+ ++
  EFC39436.1 320 NDQQNVCQRMEDYvLA-----NYQNltkyTvQEWYDNMTLCMDSFRNVEDGMR 367
                 77999999**999542.....333353344899*****************986 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.0   0.0   1.2e-24   1.1e-20       9     176 ..     455     625 ..     452     631 .. 0.89

  Alignments for each domain:
  == domain 1  score: 74.0 bits;  conditional E-value: 1.2e-24
  Guanylate_cyc   9 vtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaveskeglkvrv 104
                      i+F dI+++t++s++    +++k+Ln + a +  +++++ +y +k++Gd +++++  p    ++++  +e++ ++l   e+v+      ++++ 
     EFC39436.1 455 LDIMFVDIRNYTSMSERLPTDQMFKFLNRYLALVGPIVRRNCGYIDKYMGDGFIALFTEP---GHALKASIEIQNCVLVFNESVSPII-GPISIGC 546
                    569***************999***************************************...7777777888888887777777775.78***** PP

  Guanylate_cyc 105 GihtGpvvagviG.akkprydvwGntvnlAsrmestgk..agkiqvseetyellk....eeqfeltergevevkGkgkl 176
                    Gi +G++ +g+iG  k+++ ++ G++vnl +r+es++k  + ki vs+++ ++ +     ++ +++++g++ v Gk + 
     EFC39436.1 547 GIVRGRCAVGLIGeSKRMDPTIVGDAVNLSARLESLTKyyNAKILVSKSVTDSCSpiwlGDGGTWRSIGKICVVGKRNY 625
                    *************888999******************933468999*****9999999989999999999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (707 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       947  (0.0528195); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 4302.44
//
Query:       EFC39437.1  [L=1457]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-09   38.4   1.4    1.3e-09   38.4   1.4    2.6  2  RGS       Regulator of G protein signaling domain
    1.8e-05   24.5   0.1    5.8e-05   22.9   0.1    2.0  1  NHL       NHL repeat
    2.8e-05   24.4  29.1    0.00089   19.6   6.0    2.6  2  EGF_2     EGF-like domain
     0.0026   17.1   0.1     0.0049   16.3   0.1    1.3  1  Kdo       Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.014   16.0   0.0       0.12   13.0   0.0    2.6  2  Cna_B     Cna protein B-type domain
      0.069   13.7   0.1        0.3   11.6   0.1    2.1  1  Eco57I    Eco57I restriction-modification methylase
       0.35   10.5   2.4       0.69    9.6   0.3    2.4  2  DUF4972   Domain of unknown function (DUF4972)


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.8      0.22   5.7e+02      83     116 ..     845     889 ..     778     890 .. 0.68
   2 !   38.4   1.4     5e-13   1.3e-09       2     116 ..     975    1152 ..     974    1154 .. 0.94

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.22
                 S...........STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS  83 e...........qpsrklfeeaqeevfellekdsypkFlkselyl 116
                 e           +++ + fe   + +   l++  y+   kse+yl
  EFC39437.1 845 EikafeevipnhSEMLNYFESNVKPIVAKLKNHEYQTDYKSEMYL 889
                 25555555666689999*************************996 PP

  == domain 2  score: 38.4 bits;  conditional E-value: 5e-13
                  HHHHHTSHHHHHHHHHHHHHTTCT.HHHHHHHHHHHHHTS.........................................SHHHHHHHHHHHHHHH CS
         RGS    2 leslledqpgrslFreFlesefse.enlsFwlaveefkka.........................................keqeelkkkakeIyne 56  
                  +e++++d+  + lF e+l +  ++ e l+F+ +  e+                                            k+ ++++++a++++++
  EFC39437.1  975 FEHVMNDKECKDLFHEYLTKHAKSaELLDFLNDYREYVVYyfslnlrakpsclikdvwkkvperktepekeseevlvirknKKLDDFHAMARNLMEK 1071
                  799****************988888******************************************************9999999*********** PP

                  HTSTTSTTSSTS-HHHHHHHHHHHCSS......................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHH CS
         RGS   57 ylapsspkelnidkklreelekrleke......................qpsrklfeeaqeevfellekdsypkFlkselyl 116 
                  y+ ++s++e+ni++ +r+ + +r ++                        + ++lf    + v   le d++p+F++s+l  
  EFC39437.1 1072 YIIEGSQHEINISS-CRKDIIQRWNNInnflisdsirttvqgltqvidlLNPETLFRSSSNLVRVDLEYDQFPRFVRSDLVY 1152
                  ************85.777777788888899******************99999*************************9855 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.1   2.3e-08   5.8e-05       1      27 [.     137     164 ..     137     165 .. 0.96

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 2.3e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 fn+P  +a+d snGd+yV+D +nh +++
  EFC39437.1 137 FNRPVHIAIDhSNGDLYVTDQGNHAIRK 164
                 99***********************986 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   6.0   3.5e-07   0.00089       6      28 ..     430     451 ..     421     454 .. 0.83
   2 !   10.2  15.1    0.0003      0.76       8      32 .]     471     494 ..     461     494 .. 0.87

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 3.5e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyq 28 
                   CgghGtC +++ +C+C++g+ 
  EFC39437.1 430 KVCGGHGTCQDTN-KCVCNDGFN 451
                 57*******7666.*******95 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.0003
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 C+ghG+Cv+   +C+C+ gy G++C
  EFC39437.1 471 CSGHGKCVDYD-KCSCNYGYWGDNC 494
                 *******9666.9************ PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   1.9e-06    0.0049     118     175 ..     693     751 ..     679     764 .. 0.82

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.9e-06
         Kdo 118 elkrallkavgrliaklhr.agvnHadlyaknillqqeeeeeaeiwliDldkarlrlra 175
                 e  r+     +++ia++h+ +g+ H d+  kn+ +++ +++e+ ++liD+d ar   ++
  EFC39437.1 693 EGMRKACLSMAKAIARFHNtLGLIHCDIALKNFVIEELGNGELVFILIDFDAARFIKPE 751
                 44555566789*******747******************************99877654 PP

>> Cna_B  Cna protein B-type domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0         2   5.2e+03      10      29 ..      89     108 ..      85     118 .. 0.80
   2 ?   13.0   0.0   4.5e-05      0.12      41      73 ..     365     396 ..     338     407 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2
       Cna_B  10 annqdgkrpesitvqLlang 29 
                 ++nq+ ++ +++ v+L+a g
  EFC39437.1  89 QENQQISKSNQVYVNLVAGG 108
                 6788889999******9977 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 4.5e-05
       Cna_B  41 aennwkytftnLpkydeaGkeikYtVeEeavpg 73 
                  +++  ytf +L +y  +G+ i YtV+Ee+v++
  EFC39437.1 365 MTSTRGYTFGGLGVY-PNGDSIIYTVQEENVKK 396
                 345788*********.9*************986 PP

>> Eco57I  Eco57I restriction-modification methylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   0.00012       0.3       7      68 ..     788     849 ..     784     870 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00012
      Eco57I   7 iGNPPYqeseakkelkaleekakdiyqkFvekalkledkylaliiparfl.asgkglkefrek 68 
                  GN  Yq+++ +++l a + + +++y +F+ + +++ ++ + +i  ++f+ ++++ + e++++
  EFC39437.1 788 TGNEDYQNTT-QRDLYAYGATIEELYDIFLFQITNIINELTDMISNSKFTeEKERLTMEIKAF 849
                 59999***99.999999*********************************7777766666554 PP

>> DUF4972  Domain of unknown function (DUF4972)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.3   0.00027      0.69      34      83 ..     804     852 ..     794     887 .. 0.80
   2 ?   -0.8   0.1      0.46   1.2e+03      93     125 ..    1034    1066 ..    1027    1067 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00027
     DUF4972  34 ytaveevkteiyieqleelinkltdLrdesqyGekkgmYPeesraiLeda 83 
                 y a+ e   +i+  q+++ in+ltd+  +s++ e k++   e +a  e++
  EFC39437.1 804 YGATIEELYDIFLFQITNIINELTDMISNSKFTEEKERLTMEIKAF-EEV 852
                 5566677779**************************9988888874.444 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.46
     DUF4972   93 kikegnkaeaeeeadrlikeakkaieeFkatvr 125 
                  k+ e ++ + +e  + l+   +k++++F+a  r
  EFC39437.1 1034 KVPERKTEPEKESEEVLVIRKNKKLDDFHAMAR 1066
                  555544444455556678889999*****9877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1457 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       977  (0.0544927); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.96u 0.31s 00:00:01.27 Elapsed: 00:00:00.50
# Mc/sec: 8685.59
//
Query:       EFC39438.1  [L=364]
Description: strictosidine synthase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.7e-20   72.9   0.1    4.8e-20   71.5   0.1    1.8  1  Str_synth     Strictosidine synthase
    1.5e-17   64.0   0.0      7e-17   61.8   0.0    1.9  2  SGL           SMP-30/Gluconolactonase/LRE-like region
    0.00081   19.3   0.1        2.8    8.2   0.0    4.1  4  NHL           NHL repeat
     0.0088   16.2   0.1      0.042   14.1   0.1    2.2  2  Arylesterase  Arylesterase
  ------ inclusion threshold ------
       0.17   12.0   1.7         11    6.3   0.0    3.1  4  STT3_PglB_C   STT3/PglB C-terminal beta-barrel domain
          2    9.0   4.2        8.6    7.0   0.0    3.5  4  PQQ_3         PQQ-like domain


Domain annotation for each model (and alignments):
>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.5   0.1   1.6e-23   4.8e-20      10      88 ..     160     238 ..     151     239 .. 0.94

  Alignments for each domain:
  == domain 1  score: 71.5 bits;  conditional E-value: 1.6e-23
   Str_synth  10 gvlyftdsSskydrrqvllallegdktGrllkydkstkvvkvlldkLyfanGialsedgsfvlvcetamkrisrywike 88 
                   +yftdsS  y+r  ++  ++ ++++Grl+k+d +tk+ +v++++L+fanGia+s+d+sf+++ e++   + r+++k+
  EFC39438.1 160 KTVYFTDSSLLYSRLYFVSIVVANNPDGRLFKFDLETKQLQVVISDLKFANGIAVSKDESFLVINECSSGSLRRFYLKG 238
                 68**************************************************************************987 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.8   0.0   2.3e-20     7e-17       2     212 ..      41     283 ..      40     301 .. 0.86
   2 ?   -0.5   0.0      0.25   7.4e+02       8      32 ..     338     362 ..     335     364 .] 0.89

  Alignments for each domain:
  == domain 1  score: 61.8 bits;  conditional E-value: 2.3e-20
         SGL   2 gEGpvwdeeegaLlwvDilgqrihrldpatgketv......................ldtpe....svGaiaprkdgrlvvasksglall..dlasgel 72 
                 +E++vwd+ +  +l++ i  ++i+r++  +g +tv                          +     +G++++ k+++l+va +++ +l     + +++
  EFC39438.1  41 PESIVWDPVHADVLYTGINDGSIMRVNVTSGVSTVyaysvpalnatqravcgtsvlyE---GtcgrVLGMVFD-KNNNLIVADAYKGLLRisRANPSQV 135
                 7**********************************99999999988888877775431...2557799*****.999999998876554447777889* PP

         SGL  73 etladeeedekpllrfNDgvvdpdGr.lwfGtmgdeeakgeev.........galyrldpd.gklervlddltipNGlawspdgktlYlaDsltrkiwa 160
                 e+l+ +  + +p +  N +v  +dG+ ++f++ +   ++ + v         g l+++d + ++l++v++dl+++NG+a+s+d++ l +++   +++ +
  EFC39438.1 136 EVLVNSY-NGVPFKMTNSVVLLKDGKtVYFTDSSLLYSRLYFVsivvannpdGRLFKFDLEtKQLQVVISDLKFANGIAVSKDESFLVINECSSGSLRR 233
                 *****97.556***************9*******999999966999***************999*********************************** PP

         SGL 161 ydvdaeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwggg..kvvrfdp 212
                 + ++  g k +  +vf  +++ +g+ D + +D +Gn  v ++++   +v+ +  
  EFC39438.1 234 FYLK--GRKAGTNDVF--VQDIGGYADNIKTDDDGNFLVGLFSNTtqEVTAIHD 283
                 ***4..6667999999..55666679***************9654226666655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.25
         SGL   8 deeegaLlwvDilgqrihrldpatg 32 
                 d ++g+L+++ +l+  ++r++++tg
  EFC39438.1 338 DVRGGYLYLCSVLNPWLTRVNLSTG 362
                 67899***************99987 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.0   0.00093       2.8       6      23 ..     106     123 ..     103     127 .. 0.82
   2 ?    1.5   0.0      0.12   3.6e+02      15      28 .]     179     192 ..     178     192 .. 0.92
   3 ?    4.4   0.0     0.014        43       3      23 ..     208     229 ..     206     234 .. 0.77
   4 ?   -2.2   0.0       1.7   5.2e+03      10      17 ..     261     268 ..     258     269 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00093
                 EEEEETTTEEEEEECCCT CS
         NHL   6 GvavdsnGdiyVaDsenh 23 
                 G + d+n++++VaD +  
  EFC39438.1 106 GMVFDKNNNLIVADAYKG 123
                 88999*********7765 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.12
                 EEEEECCCTEEEEE CS
         NHL  15 iyVaDsenhrvqvF 28 
                 i+Va++   r+++F
  EFC39438.1 179 IVVANNPDGRLFKF 192
                 89********9998 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.014
                 SEEEEEEETTTEEEEEE.CCCT CS
         NHL   3 yPhGvavdsnGdiyVaD.senh 23 
                 +++G+av+++  ++V + + + 
  EFC39438.1 208 FANGIAVSKDESFLVINeCSSG 229
                 789************9965555 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 1.7
                 ETTTEEEE CS
         NHL  10 dsnGdiyV 17 
                 d++G+++V
  EFC39438.1 261 DDDGNFLV 268
                 799**999 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.74   2.2e+03      53      73 ..     147     167 ..     140     180 .. 0.75
   2 !   14.1   0.1   1.4e-05     0.042      42      73 ..     195     226 ..     158     235 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.74
  Arylesterase  53 lssanGInidadkkyiyvadi 73 
                   +++ n +++  d k +y +d+
    EFC39438.1 147 FKMTNSVVLLKDGKTVYFTDS 167
                   556677777778888887764 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 1.4e-05
  Arylesterase  42 spsevkvvasglssanGInidadkkyiyvadi 73 
                   ++++++vv+s l++anGI ++ d+ ++ + + 
    EFC39438.1 195 ETKQLQVVISDLKFANGIAVSKDESFLVINEC 226
                   57899*******************99988765 PP

>> STT3_PglB_C  STT3/PglB C-terminal beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0     0.026        79      16      39 ..     148     171 ..     139     184 .. 0.83
   2 ?    6.3   0.0    0.0035        11       5      34 ..     196     225 ..     192     238 .. 0.83
   3 ?   -3.3   0.0       3.3   9.9e+03      56      71 ..     277     292 ..     273     293 .. 0.76
   4 ?   -2.3   0.0       1.7     5e+03      44      54 ..     321     331 ..     310     344 .. 0.49

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.026
                  EETTTEEEETTTTEEEETTEEEEE CS
  STT3_PglB_C  16 eLgnGivlskdfkslkiggqkvpv 39 
                  ++ n +vl kd k++++ + ++  
   EFC39438.1 148 KMTNSVVLLKDGKTVYFTDSSLLY 171
                  6899*************9998755 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0035
                  E-EEE-----EEETTTEEEETTTTEEEETT CS
  STT3_PglB_C   5 skaikqknegveLgnGivlskdfkslkigg 34 
                  +k++++  + ++++nGi +skd + l i++
   EFC39438.1 196 TKQLQVVISDLKFANGIAVSKDESFLVINE 225
                  667777788999************999987 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 3.3
                  ..EE--TT--EEEEEE CS
  STT3_PglB_C  56 keteidskaqlyvifm 71 
                  ++t i+++a+l  if+
   EFC39438.1 277 EVTAIHDSAKLKNIFL 292
                  4688999999988887 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 1.7
                  EEEETTTTEEE CS
  STT3_PglB_C  44 eteydkngklk 54 
                   + +dk   ++
   EFC39438.1 321 TVYSDKTATFA 331
                  23334444444 PP

>> PQQ_3  PQQ-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.5      0.25   7.5e+02      20      38 ..      50      68 ..      30      80 .. 0.63
   2 ?   -1.6   0.1       1.4   4.3e+03      28      36 ..      70      78 ..      67     104 .. 0.67
   3 ?    7.0   0.0    0.0029       8.6      20      40 .]     158     196 ..     142     196 .. 0.84
   4 ?   -1.2   0.0       1.1   3.3e+03      19      36 ..     339     357 ..     328     361 .. 0.73

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.25
       PQQ_3 20 dgglvyvgtgdGtlyAlDa 38
                  +++y+g  dG++  ++ 
  EFC39438.1 50 HADVLYTGINDGSIMRVNV 68
                3467888888887766554 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.4
       PQQ_3 28 tgdGtlyAl 36
                +g  t+yA+
  EFC39438.1 70 SGVSTVYAY 78
                555566665 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0029
       PQQ_3  20 dgglvyvgtg..................dGtlyAlDaet 40 
                 dg +vy++++                  dG+l+ +D et
  EFC39438.1 158 DGKTVYFTDSsllysrlyfvsivvannpDGRLFKFDLET 196
                 6779999999999999999999999***********998 PP

  == domain 4  score: -1.2 bits;  conditional E-value: 1.1
       PQQ_3  19 vdgglvyvgtg.dGtlyAl 36 
                 v gg++y  +  +  l+ +
  EFC39438.1 339 VRGGYLYLCSVlNPWLTRV 357
                 6799999987666666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (364 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       477  (0.0266049); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.49
# Mc/sec: 2253.13
//
Query:       EFC39439.1  [L=754]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      4e-24   85.2  21.4    6.6e-24   84.5  21.4    1.4  1  ABC2_membrane  ABC-2 type transporter
    2.1e-11   44.5   0.0    6.5e-11   42.9   0.0    1.9  1  ABC_tran       ABC transporter
    0.00067   19.5   1.7     0.0021   17.9   1.7    1.8  1  PDR_CDR        CDR ABC transporter
     0.0035   16.2   0.2     0.0057   15.5   0.2    1.2  1  ABC_ATPase     Predicted ATPase of the ABC class
     0.0051   16.7   0.7       0.26   11.1   0.0    2.5  2  AAA_21         AAA domain, putative AbiEii toxin, Type IV TA 


Domain annotation for each model (and alignments):
>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.5  21.4   1.8e-27   6.6e-24       3     210 .]     467     672 ..     465     672 .. 0.92

  Alignments for each domain:
  == domain 1  score: 84.5 bits;  conditional E-value: 1.8e-27
  ABC2_membrane   3 ikallkreflqrwrdpslgllwrliqplllalvfgtvfgnlgnsedgl.nrpgllffsvlflafsaltsvapvferergvlerelvsplyslsayv 97 
                    ++ l+ r++l+r+r++   +l +l++ l +++++g+++++++  e+ +  r  ++ f+ l+++ +++t++  + + + ++l +e++s +y++s+++
     EFC39439.1 467 VFFLMARNYLSRIRNWKVEFLIPLLEKLAVSIFIGLLYFQID--EGNMsLRGKIFTFLNLNIS-LTFTASLKNLINQIPMLTQERNSSIYRTSVFF 559
                    67899**********************************987..4556345666777777777.8888888************************* PP

  ABC2_membrane  98 lakvlvelpvsllqalifllivyflvgldls..rfflflllllltalaasslgllisalapsfedasqlaslvllpllllsGffipidsmpkwlqw 191
                    ++k++ +l+ + +++l+f  ivyf+++l+l+  r++ f l++  ++++++s++ ++ +l p     +++++++ ++++l+sG++   ++   wl w
     EFC39439.1 560 ISKTIEDLIETSILSLLFGWIVYFMTNLRLEydRVLTFGLIFATYHWTCVSFAQMLVSLIPVPPLLNLITPVINIMFILTSGVYGF-PNTD-WLSW 653
                    *******************************9999************************************************955.5555.**** PP

  ABC2_membrane 192 iaylnPltyavealrsnlf 210
                    + yln+l+y+++a+  n+f
     EFC39439.1 654 FKYLNYLFYGFKAMSLNEF 672
                    **************99887 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.9   0.0   1.8e-14   6.5e-11       2     136 ..     153     312 ..     152     313 .. 0.92

  Alignments for each domain:
  == domain 1  score: 42.9 bits;  conditional E-value: 1.8e-14
                 EEEEEEEETTSEEEEEESTTSSHHHHHHHHT..TSS--SEEEEEETTCEGGG........B-HHHCCHCEEEE-SS.--S-TTSBHHHH.......... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxxxx.xxxxxxxxxxxx.......... RF
    ABC_tran   2 knvslklkegekvaivGenGaGKStLlklla..gllkpteGeilldgkdlke........qeleslrkeigvlpqe.pqlfpeltvren.......... 79 
                 +nvs  + +g+++ai+G+  +GK+tLl++l+  g++k+  G il++gk +++        ++ +++++ i+ +p++ +   p ltvre           
  EFC39439.1 153 RNVSGFVAPGKITAIIGSALSGKTTLLSILSqrGNYKDFGGLILINGKVVRTckegpcakISSTQYKSLIAHVPKHfTASHPFLTVREIlnftvklklt 251
                 799999************************8445788899***9999999999999999999**************899999******9********** PP

                 ........HHHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTT CS
                 ........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  80 ........esdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpt 136
                          ++e++e +l+k++lke++d+      s+L   +k+r+ +a   + k ++lll  pt
  EFC39439.1 252 svksaltkCREERLEYLLTKYELKEKEDELY----SKLGVAEKRRLHIAVQNVLKHRVLLLEYPT 312
                 9999999777888************999998....*************************98777 PP

>> PDR_CDR  CDR ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   1.7   5.9e-07    0.0021      24      75 ..     685     738 ..     679     744 .. 0.88

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 5.9e-07
     PDR_CDR  24 pGqeyVsGddYlelsfgysssh..lwrnfgiliaflifflalyllatelisaek 75 
                 p + y +G+ +l +++gys  h  +w  fgil  f+i+  +l  + + l+  +k
  EFC39439.1 685 PANYYTNGTYFLYKNYGYSDPHymMWVYFGILTSFWIVCKILSYVGLRLVYGKK 738
                 677899***************9889**************999999888877666 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.2   1.6e-06    0.0057     235     269 ..     153     188 ..     149     193 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.6e-06
                 EEEEEEEE-SSEEEEEE-TTSSHHHHHHHH.HHCCS CS
  ABC_ATPase 235 kkvsGmgipkGvtlIvGggfhGKsTLLeAl.ekGvy 269
                 ++vsG   p ++t+I+G++  GK+TLL+ l ++G y
  EFC39439.1 153 RNVSGFVAPGKITAIIGSALSGKTTLLSILsQRGNY 188
                 689************************998345666 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.2     0.013        48       1      20 [.     164     183 ..     164     219 .. 0.84
   2 !   11.1   0.0   7.2e-05      0.26     259     303 .]     304     348 ..     238     348 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.013
      AAA_21   1 lnvliGpNgsGKSnLLdald 20 
                 ++++iG   sGK++LL +l+
  EFC39439.1 164 ITAIIGSALSGKTTLLSILS 183
                 688888888**********5 PP

  == domain 2  score: 11.1 bits;  conditional E-value: 7.2e-05
      AAA_21 259 sllliDEpEngLHPkllrrllellkelsrngaQviltTHSpllld 303
                 ++ll++ p  gL+    +r+++++k+ ++ g+ v+lt+H p+ll+
  EFC39439.1 304 RVLLLEYPTDGLEFGEASRIIRIMKSIAKMGVGVVLTSHKPSLLE 348
                 89****************************************995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (754 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       763  (0.0425568); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.76u 0.34s 00:00:01.10 Elapsed: 00:00:00.51
# Mc/sec: 4470.14
//
Query:       EFC39440.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.8e-34  115.7   0.4    6.2e-18   64.1   0.0    2.4  2  SH3_1     SH3 domain
    3.9e-29  100.3   0.1    3.7e-14   52.3   0.0    2.3  2  SH3_9     Variant SH3 domain
    2.4e-22   78.3   0.0    2.2e-10   40.0   0.0    2.4  2  SH3_2     Variant SH3 domain
      9e-16   58.2  13.4    1.6e-15   57.4  13.4    1.3  1  BAR       BAR domain
    4.5e-10   39.6  16.0    6.9e-10   39.0  16.0    1.2  1  BAR_3     BAR domain of APPL family
    1.8e-08   34.2  11.7      2e-08   34.1  10.8    1.5  1  Arfaptin  Arfaptin-like domain
  ------ inclusion threshold ------
       0.05   12.8   7.4      0.071   12.3   7.4    1.3  1  Med3      Mediator complex subunit 3 fungal


Domain annotation for each model (and alignments):
>> SH3_1  SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.7   0.1     8e-17     2e-13       1      48 []     317     365 ..     317     365 .. 0.98
   2 !   64.1   0.0   2.4e-21   6.2e-18       1      48 []     382     429 ..     382     429 .. 0.98

  Alignments for each domain:
  == domain 1  score: 49.7 bits;  conditional E-value: 8e-17
                 EESSSBEXSSTTBXEBSTTEEEEEEEECSSSEEEEEETTS.TEEEEEEG CS
       SH3_1   1 iAlYDYeaeesdELsfkkGDviivleksedgWwkgrlkgt.gkeGliPs 48 
                 +A+Y Y+a++s E+sf++G++i v ek+e+gWw+g +  t  k G++Ps
  EFC39440.1 317 KAMYTYDAQDSTEISFTEGETILVYEKEEGGWWRGAREATpTKSGIFPS 365
                 79***************************************9******8 PP

  == domain 2  score: 64.1 bits;  conditional E-value: 2.4e-21
                 EESSSBEXSSTTBXEBSTTEEEEEEEECSSSEEEEEETTSTEEEEEEG CS
       SH3_1   1 iAlYDYeaeesdELsfkkGDviivleksedgWwkgrlkgtgkeGliPs 48 
                 +AlYDYea+es+EL+fk G+vi+v+e+ ++gW+ g++ +t+k+Gl+Ps
  EFC39440.1 382 TALYDYEAQESNELTFKAGEVIEVIEEADGGWFMGKNLSTNKVGLFPS 429
                 59*********************************************8 PP

>> SH3_9  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.0   0.0   1.4e-15   3.5e-12       1      48 [.     318     368 ..     318     369 .. 0.94
   2 !   52.3   0.0   1.4e-17   3.7e-14       1      49 []     383     433 ..     383     433 .. 0.97

  Alignments for each domain:
  == domain 1  score: 46.0 bits;  conditional E-value: 1.4e-15
       SH3_9   1 AlypyepreddeLsLqrGDvitvieesedgWlegsl...tGrtGlvPanyv 48 
                 A+y y++++ +e+s+ +G++i+v e++e+gW++g +     ++G +P+n+v
  EFC39440.1 318 AMYTYDAQDSTEISFTEGETILVYEKEEGGWWRGAReatPTKSGIFPSNFV 368
                 89********************************9765567*********8 PP

  == domain 2  score: 52.3 bits;  conditional E-value: 1.4e-17
       SH3_9   1 AlypyepreddeLsLqrGDvitvieesedgWlegsl..tGrtGlvPanyve 49 
                 Aly+ye++e  eL + +G+vi viee+++gW+ g++  t + Gl+P+n++e
  EFC39440.1 383 ALYDYEAQESNELTFKAGEVIEVIEEADGGWFMGKNlsTNKVGLFPSNFTE 433
                 8**********************************87999********986 PP

>> SH3_2  Variant SH3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.0   0.0   8.6e-14   2.2e-10       2      54 ..     316     368 ..     315     369 .. 0.89
   2 !   36.0   0.0   1.6e-12   4.2e-09       5      53 ..     384     431 ..     382     434 .. 0.91

  Alignments for each domain:
  == domain 1  score: 40.0 bits;  conditional E-value: 8.6e-14
                 EEESS-B-SCGCCB--B-TTEEEEEE..EEEECTTEEEEEE..C.CCEEEEEGCGE CS
       SH3_2   2 vraiedyvgedkseLsfkkGdvikvlslgskdsdgwwegev..g.GrvGlfPsslv 54 
                 ++a+ +y+++d +e+sf++G++i v+   +k+ +gww+g++     + G+fPs++v
  EFC39440.1 316 CKAMYTYDAQDSTEISFTEGETILVY---EKEEGGWWRGAReaTpTKSGIFPSNFV 368
                 79999*********************...***********95423555******98 PP

  == domain 2  score: 36.0 bits;  conditional E-value: 1.6e-12
                 SS-B-SCGCCB--B-TTEEEEEE..EEEECTTEEEEEE..CCCEEEEEGCG CS
       SH3_2   5 iedyvgedkseLsfkkGdvikvlslgskdsdgwwegev..gGrvGlfPssl 53 
                 + dy+++  +eL+fk+G+vi v+   ++ ++gw  g +   ++vGlfPs++
  EFC39440.1 384 LYDYEAQESNELTFKAGEVIEVI---EEADGGWFMGKNlsTNKVGLFPSNF 431
                 569********************...888889999999999********97 PP

>> BAR  BAR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.4  13.4   6.4e-19   1.6e-15       9     238 ..       5     222 ..       3     223 .. 0.86

  Alignments for each domain:
  == domain 1  score: 57.4 bits;  conditional E-value: 6.4e-19
         BAR   9 sqlleekvgkaekTkLDed.FeelerrldvteklieklvkelkeylqanpgarakqivleklkeqplelLaesmieagkelgedssfgkalekygeavk 106
                 +q ++ k+gkae T+ D++ +++l + +++te+  +  +k +++y q   + +  q            ++++++ e g++   +++ g+ l k ge +k
  EFC39440.1   5 KQRIKVKLGKAESTQ-DPEgYNDLRDQVKKTENYAKGALKIVRGYCQKSEAITKVQN-----------EVGQYLVESGMQT--NDEVGESLMKIGEGLK 89 
                 789999*********.9766***************************8888888888...........************9..55568*********** PP

         BAR 107 klaqteeelekrvetnfldplrellekefkeiqkerkklehkrlDyDaakarlkklktkkskkakde...ekaeeelrkAqqkfeesneelkaeLpnll 202
                  la+  + +  ++ ++f++p +e+  ke+k+ +   kk ++krl +Da    +++lk+k + k++ +    + e++ +   +k e + e l++  + l+
  EFC39440.1  90 SLATIHHAMLVNIVEKFIQPATEFK-KEVKDSEVSHKKYDKKRLEFDAQVDLVNSLKQKGE-KVDPQkvqTEEEKQTQFDNEKDEAFEETLEETCDVLV 186
                 *************************.*******************************6554.4444456544444444445555666666666666777 PP

         BAR 203 alevefvnqlqafveaqldfhkqaaqlleqlqqqls 238
                 + +++++ ql++++     f+++ ++l ++l++ l+
  EFC39440.1 187 KRQTKHLAQLNELLLSFHHFFAEGYTLTHDLKEPLE 222
                 788888899999999999999999999999999886 PP

>> BAR_3  BAR domain of APPL family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0  16.0   2.7e-13   6.9e-10      22     234 ..      29     241 ..      24     243 .. 0.77

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 2.7e-13
       BAR_3  22 aeleelekklkkllKlckrlieagkaysaaqkqfaqsLrelkkeskgdeetdesLkkfsellqelenehtilldqaqrsikkpLekFrkedlkevkekk 120
                 + ++++e++ k  lK ++ ++++ +a+ + q+++ q L e  +  ++++e+ esL k++e l+ l+  h  +l ++ +++++p ++F k ++k  + ++
  EFC39440.1  29 DQVKKTENYAKGALKIVRGYCQKSEAITKVQNEVGQYLVESGM--QTNDEVGESLMKIGEGLKSLATIHHAMLVNIVEKFIQPATEFKK-EVKDSEVSH 124
                 5688899999999999999999999999999999988877666..5678899**********************************966.7999999** PP

       BAR_3 121 kkFdkesekleaaleknaqlskkkk...esele...eadnelkatrkkfhqasldyvlqinelqerkkfeiletllsfmqaqltFfhqGyelfkdlepf 213
                 kk+dk++ +++a+++   +l++k +   +++++   e +++ ++++ +  ++ l+  + + +   +++++ l +l +++ +   Ff +Gy l++dl++ 
  EFC39440.1 125 KKYDKKRLEFDAQVDLVNSLKQKGEkvdPQKVQteeEKQTQFDNEKDEAFEETLEETCDVLV---KRQTKHLAQLNELLLSFHHFFAEGYTLTHDLKEP 220
                 ***********998877777766431113444432355566667777777777777776655...4444455555555555667*************99 PP

       BAR_3 214 mkeLsaqlqqlrarfeetaee 234
                 +++L ++ ++  + f++++ e
  EFC39440.1 221 LEKLMEKSNKKASTFKQQTVE 241
                 988888888877779887655 PP

>> Arfaptin  Arfaptin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.1  10.8   7.7e-12     2e-08      11     219 ..       3     208 ..       1     217 [. 0.78

  Alignments for each domain:
  == domain 1  score: 34.1 bits;  conditional E-value: 7.7e-12
                 XXXXXXXXXXXXX--....CHHHH.HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..H-CCGHHHHHHHHHHHHHHHHHHH CS
    Arfaptin  11 itkqvlseklgkkedervitvdde.LeaklevlreiketykelvklaknlskallklsqtekelGdvfkdlskrekqealgeaftatgealrllakqge 108
                 + kq ++ klgk e     t d e  +   ++ +++++  k+ +k+++ + ++   ++++++e G+++ + ++ + + ++ge++ + ge l++la    
  EFC39440.1   3 VFKQRIKVKLGKAES----TQDPEgYNDLRDQVKKTENYAKGALKIVRGYCQKSEAITKVQNEVGQYLVESGM-QTNDEVGESLMKIGEGLKSLATIHH 96 
                 567888888888888....7887634455588999**************************************.889999*************998776 PP

                 HHH.HHHHHHHHHHHHHHHTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..TSTSSTTCHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHHHHHH CS
    Arfaptin 109 all.kalkrfiselntfvnkaieDTllTikkyedarieYrayllklkeasdEldpevakqeekfreaqenvqeake.kfdklrkDvlqKveLLeekrvk 205
                 a+l + +++fi+  +t  +k ++D ++  kky + r+e++a+   ++++++  +  + ++ +  +e+q+++ ++k+  f+   + ++  +   + k+  
  EFC39440.1  97 AMLvNIVEKFIQP-ATEFKKEVKDSEVSHKKYDKKRLEFDAQVDLVNSLKQKGEKVDPQKVQTEEEKQTQFDNEKDeAFEETLEETCDVLVKRQTKHLA 194
                 6550566778776.78889************************99999996554444444555667899997777516877655444333334577777 PP

                 HHHHHHHHHHHHHH CS
    Arfaptin 206 vlskqLalyqnala 219
                  l++ L ++++  a
  EFC39440.1 195 QLNELLLSFHHFFA 208
                 77777777776655 PP

>> Med3  Mediator complex subunit 3 fungal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   7.4   2.8e-05     0.071     108     207 ..     215     313 ..     130     333 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.8e-05
        Med3 108 aknkdksfqlLenLsaynkkGkas..askasvvnstpssaastPttta.tPg..antktaakslpapnatatigtptnsaaaaattatttssqakkPrk 201
                  + k+     Le+L  +++k   +  + + ++v +  +s+ stP  ++ tP   +nt+t + ++++ ++ta+ +t+t+s++a      ++ s akk   
  EFC39440.1 215 HDLKE----PLEKLMEKSNKKASTfkQQTVESVLGGGGSIRSTPSQSSfTPStkSNTETSTSTVTT-TSTAKSSTNTTSTSAVGGMG-AAFSAAKKTES 307
                 44444....455554444333333003344455566777888887543366511555556666655.78888888877766655444.56677888766 PP

        Med3 202 Prqtkk 207
                    t  
  EFC39440.1 308 AAATVL 313
                 655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2035  (0.113503); expected 358.6 (0.02)
Passed bias filter:                      549  (0.0306208); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 2648.97
//
Query:       EFC39441.1  [L=195]
Description: hypothetical protein NAEGRDRAFT_81269 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (195 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       692  (0.0385967); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1236.00
//
Query:       EFC39442.1  [L=556]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-73  247.1   0.3    6.3e-73  245.4   0.1    2.0  2  Dak1      Dak1 domain
    2.3e-35  122.1   0.0    3.8e-35  121.3   0.0    1.4  1  Dak2      DAK2 domain


Domain annotation for each model (and alignments):
>> Dak1  Dak1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  245.4   0.1   7.1e-77   6.3e-73      52     308 ..       1     277 [.       1     280 [. 0.87
   2 ?   -1.8   0.0      0.13   1.1e+03     219     276 ..     369     431 ..     362     438 .. 0.72

  Alignments for each domain:
  == domain 1  score: 245.4 bits;  conditional E-value: 7.1e-77
                 SBSEEEEEEETS---HHHHHHHHHHH--S.......S-EEEEEESSHHHHHHHHHHHHHHHHTT--EEEEEE--B-SSSSSTTCSSSB--THHHHHHHH CS
        Dak1  52 mldaavaGevFaSPsakqilaaikavdsg.......kGvllivkNYtGDvlnfglAaekakaegikvetvvvdDDvavedseekagrRGvagtvlveKi 143
                 ml+aav G+vF+SPs+ qi++ai+av+s        kG+llivkNYtGD+lnf lA e+a ++g++ve+++v+DDv          +RGvagtv+++K+
  EFC39442.1   1 MLTAAVLGAVFTSPSVLQIFKAITAVTSRrrvdeegKGCLLIVKNYTGDILNFRLAREMAIQDGYNVEMIIVGDDVTH--------QRGVAGTVFIHKL 91 
                 9*************************6655666777****************************************98........7************ PP

                 HHHHHHHT--HHHHHHHHHHH........HTT.....EEEEEEEEE--B-TTTSSBSS---TT..EEEETE-TTS---SEEEE---HHH...HHHHHHH CS
        Dak1 144 aGaaAeegasLeevaelaekv........aen.....lrsigvalsactvpgagkpsfelaed..eielGlGiHgEpGvervklksade...lveelle 224
                 +Ga+Ae+g+sL+e+ e++++          +n     +rsig+ l++ ++pg+++p  el++    +elGlGiHgE+Gv r ++++++    + ++++e
  EFC39442.1  92 CGAMAERGDSLSEIFEFMKSKlkitseqvLNNgnesfIRSIGIGLNSISMPGNSEPLYELSDSdpVYELGLGIHGEKGVCRLTFSPTNPvteISNTMIE 190
                 **************9987642122222223333344479********************99874469**************999886543349999*** PP

                 HHHH.....TT-EEEEEEEE-BSS-HHHHHHHHHHHHHHHHHTT-EEEEEEEESSS--TTBEEEEEEEEEE-...HHHHHHHHS-EE CS
        Dak1 225 klledkelkkgdevvllvNglGgtsllelyivarevaelleekgikvvrvlvGeyvTsldmaGfsitllkld...dellelldapve 308
                 +ll ++  +++ +++l++N+lG+t+lle+y +ar v +lle+++i+++rv+vG+++T+l+m+Gfs++ll+l    ++llelld+p+e
  EFC39442.1 191 HLLPKEFSAENLKFALMINNLGSTTLLEMYNIARVVITLLENQNISIERVYVGTFMTALNMHGFSLSLLNLAqnsEQLLELLDTPTE 277
                 ***845566689***********************************************************7566888999999887 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.13
                 HHHHHHHHHH..........TT-EEEEEEEE-BSS-HHHHHHHHHHHHHHHHHTT-EEEEEEE CS
        Dak1 219 veelleklledke.....lkkgdevvllvNglGgtsllelyivarevaelleekgikvvrvlv 276
                 +e + +++l++++     ++   ++ + v + Gg s   +++++ +  + l++++++ ++ ++
  EFC39442.1 369 CESIQQHILKKQDlkmtlAELVYQIGICVQNSGGSSGAIISMFFLRYSKSLKTNSFDHKKAFI 431
                 555666677644432332222567889999999999999999999999999999888877665 PP

>> Dak2  DAK2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  121.3   0.0   4.2e-39   3.8e-35       1     169 [.     355     516 ..     355     520 .. 0.91

  Alignments for each domain:
  == domain 1  score: 121.3 bits;  conditional E-value: 4.2e-39
                 TTS-S-HHHHHHHHHHHHHHHHHC-..--SSHHHHHHHHHHHHHHH--STHHHHHHHHHHHHHHHC.....TT---HHHHHHHHHHHHHHHH---TTSS CS
        Dak2   1 pvGDGDtGtnmargaeavlkaleel..eeaslaevlkalakallsgagGtsGvlysqflralakalkekeeldaedlaaalkaaleaiqavgkarpgdk 97 
                 +vGDGD+G+ ++r++e++++++ ++   + +lae++ +++  + ++ gG+sG+++s f+++ +k+lk++    + d ++a+ +++++++++g +++gd+
  EFC39442.1 355 EVGDGDCGSAIERACESIQQHILKKqdLKMTLAELVYQIGICV-QNSGGSSGAIISMFFLRYSKSLKTN----SFDHKKAFIEGVHGMMELGDSKKGDR 448
                 59*******************9888788889999999998665.777*******************654....5699********************** PP

                 STHHHHHHHHHHHHT...........T---HHHHHHHHHHCCS---SSGGGGGGGGGTTS--HHHHHHHHHH CS
        Dak2  98 TmlDvlrpavealekakdgedlkealekaakaaekgaeaTkellaklgrAsylgerslgvvDpGAvglalil 169
                 TmlD+l+p++e l+++++       +e ++k a++g+++Tk++lak gr++ylg+r lg  DpGA  +  i+
  EFC39442.1 449 TMLDTLIPVSEYLQEQEE----SIDVETIVKVANEGMDSTKSMLAKRGRSRYLGDRVLGFLDPGALCMFDIV 516
                 ***************776....445899*************************************9887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (556 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       443  (0.0247086); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 3647.63
//
Query:       EFC39443.1  [L=433]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (433 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       463  (0.0258241); expected 358.6 (0.02)
Passed bias filter:                      228  (0.0127168); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2596.79
//
Query:       EFC39444.1  [L=563]
Description: arfGTPase-activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.9e-25   88.6   2.5    3.7e-25   88.3   1.1    2.0  2  ArfGap    Putative GTPase activating protein for Arf
    3.9e-09   36.7   5.3    1.8e-08   34.6   5.3    2.2  1  BTB       BTB/POZ domain


Domain annotation for each model (and alignments):
>> ArfGap  Putative GTPase activating protein for Arf
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.3   1.1   4.2e-29   3.7e-25       2     114 ..       8     119 ..       7     122 .. 0.93
   2 ?   -2.4   0.0      0.54   4.8e+03      64      85 ..     405     426 ..     391     447 .. 0.66

  Alignments for each domain:
  == domain 1  score: 88.3 bits;  conditional E-value: 4.2e-29
                 HHHHHHCCSCCCCB-TTT-SBS--EEETTTTEEE-HHHHHHHC.CS.TTT--EEETTTS---HHHHHHHH.HTCHHHHHHHHTTTC-TTTSG-TTCGHH CS
      ArfGap   2 kalkellkepenkvCaDCgakeptWaslnlgvflCieCsgvHr.slgvhiskvrsltldkwedeelellk.algNkkaneileaklpkeekrskssske 98 
                 k++++l++ p+n++CaDC+a++p++a ++  ++ Ci+C+g+ r ++g+h+ + r + ld+w++e+ + +  ++gN+ +n+ilea+l++++++   ++ +
  EFC39444.1   8 KQISQLVSLPGNNKCADCQAPNPRFADIKQFTLSCISCAGIKRtKIGTHVCQLRVVGLDTWKEEHFNAMIeQGGNDAVNRILEAELKDQDRK---EEMK 103
                 67899*************************************9558*******************9987669**************777777...999* PP

                 HHHHHHHHHHTCHTTC CS
      ArfGap  99 kreefirakYeekkfa 114
                 ++++firakYee +++
  EFC39444.1 104 DMTRFIRAKYEEMRWK 119
                 ************9996 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.54
                 HHHHHHHHTCHHHHHHHHTTTC CS
      ArfGap  64 eelellkalgNkkaneileakl 85 
                 + l+++ + gN ++ +i+   +
  EFC39444.1 405 KCLQFISNYGNVNNIKIYLPFN 426
                 5678888888888777776544 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.6   5.3     2e-12   1.8e-08       4     107 ..     440     558 ..     437     560 .. 0.87

  Alignments for each domain:
  == domain 1  score: 34.6 bits;  conditional E-value: 2e-12
                 HHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST...............TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-..CGGGHH CS
         BTB   4 lresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk...............eieessvseielddvepeafealLefiYtgeleit..seenle 85 
                 l+++++ +D+t++++ ++ f+ h+ vL + S++Fk ++ ++               ei ++s+ + ++++   + f +l+++ Y  e++++  +   + 
  EFC39444.1 440 LFNCQKSSDITIKIE-NELFYLHRTVLTSKSSVFKIILDENskfndvknnileidcEIFKNSK-NGNVPNLMVKCFTILFNYFYDFEIDLSkfNFYLMS 536
                 789999*********.6************************9998888888888774444443.47779*********************988667899 PP

                 HHHHHHHHHT-HHHHHHHHHHH CS
         BTB  86 elLaaadllqiprlkkaceefl 107
                  lL++ +++q+++  +++ + l
  EFC39444.1 537 TLLEMSQFYQLDQFHDKINNEL 558
                 99999********999988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (563 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       773  (0.0431145); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 3238.99
//
Query:       EFC39445.1  [L=266]
Description: hypothetical protein NAEGRDRAFT_81270 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-18   67.5   0.0    2.2e-18   67.1   0.0    1.1  1  ATG27          Autophagy-related protein 27
    2.1e-07   30.3   0.1    1.5e-06   27.5   0.0    2.2  2  Man-6-P_recep  Mannose-6-phosphate receptor
     0.0093   16.0   0.0      0.066   13.3   0.1    2.0  2  CIMR           Cation-independent mannose-6-phosphate recepto
  ------ inclusion threshold ------
       0.15   11.9   0.2        4.3    7.3   0.2    2.5  2  DUF1344        Protein of unknown function (DUF1344)


Domain annotation for each model (and alignments):
>> ATG27  Autophagy-related protein 27
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.1   0.0     5e-22   2.2e-18       4     249 ..      14     246 ..      10     259 .. 0.81

  Alignments for each domain:
  == domain 1  score: 67.1 bits;  conditional E-value: 5e-22
       ATG27   4 llallaaasaa..ldCskivvdkglkkydlsklkgphsvstseetppsktnttytldiCeplkkkkdvkkedqCpkgtrvCgitrvikkdekdeitqvi 100
                 +++ll  +s      Cs i+ ++g++  d+skl+ +   ++  +   +  n++++++iC  lkk             ++vC +     +  +++i    
  EFC39445.1  14 ITFLLFESS-IlaQTCS-ITLSDGTS-IDVSKLDTTNGYVSNDD---KDPNYKFYFNICGGLKKP------------SDVCLVDGQAFQ-YSNDINLCY 93 
                 333333333.33589*9.88885777.******77666665554...56699*******888776............789988877775.6778999** PP

       ATG27 101 piggksldpkvtrlkesdekeglrlelkggkygkkkqkaiieflCd..ekslkfksydeee.eeekdvlrlewktkyACekaekdkkdsskkkek...s 193
                 pi +k  +p+vt l+ +dek g+++  +  +  ++++++++e+ Cd    +    +y +e+ +  + v++++ +tk+ C + + d+++  +++ +   +
  EFC39445.1  94 PI-SKPNTPTVTLLNPADEKAGVKVVHQPVSMDRTSRQLSLEISCDvnGPAAPSFKYMKEQiNGGIIVYSFSGSTKSICPGVKPDPNNPTNDS-DlplG 190
                 **.***************************9**************85544445556666667999***************9988888877654.369*5 PP

       ATG27 194 gwGfFtwlfiilflataaYlifgswlNynryGargwDllphgdtirdlPyllkDvv 249
                 + G    +++++++a+++Y+i+g  +   + + +g + +p+  +++dlP l+ D++
  EFC39445.1 191 QYGIGGLIMTLALVALILYFIIGFAILKFKMQKTGTEVIPQFTFWKDLPFLFIDGI 246
                 55655799999999*****999987777779*********************9987 PP

>> Man-6-P_recep  Mannose-6-phosphate receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0     0.067     3e+02      43      68 ..      54      78 ..      38      91 .. 0.72
   2 !   27.5   0.0   3.3e-10   1.5e-06     165     217 ..     194     246 ..     126     263 .. 0.89

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.067
  Man-6-P_recep 43 eekdkytyklrvCreveesaedagli 68
                    ++ +y++ +++C   ++++ d  l+
     EFC39445.1 54 DKDPNYKFYFNICGGLKKPS-DVCLV 78
                   33449********9998854.44555 PP

  == domain 2  score: 27.5 bits;  conditional E-value: 3.3e-10
  Man-6-P_recep 165 vGsillivllslvavyligGflyqrlvvgakGleqiPnyafWqdlGnlvadGC 217
                    +G +++ + l  + +y+i+Gf   ++ ++  G e iP+++fW+dl  l  dG 
     EFC39445.1 194 IGGLIMTLALVALILYFIIGFAILKFKMQKTGTEVIPQFTFWKDLPFLFIDGI 246
                    666666666666778***********************************996 PP

>> CIMR  Cation-independent mannose-6-phosphate receptor repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.3   0.1   1.5e-05     0.066      49     102 ..      26      77 ..      22     104 .. 0.72
   2 ?    0.1   0.0      0.17   7.6e+02      12      45 ..     137     175 ..     127     192 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.5e-05
        CIMR  49 veCqvtdaagkeyDLsaLsrksenweavdtsasgkkkhfyinvCk.peakiegCp 102
                   C++t + g ++D+s+L ++++ +   d+++   + +fy n+C   +  ++ C 
  EFC39445.1  26 QTCSITLSDGTSIDVSKLDTTNG-YVSNDDKDP--NYKFYFNICGgLKKPSDVCL 77 
                 57****************98876.666666666..789******94222334443 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.17
        CIMR  12 Cnetaledapvf..lkedi..gdcsylFewetalACv..e 45 
                 C+ +  + ap f  +ke+i  g+  y F  +t+  C+  +
  EFC39445.1 137 CDVNG-PAAPSFkyMKEQIngGIIVYSFSGSTKSICPgvK 175
                 55443.5555541156666778999999999999998433 PP

>> DUF1344  Protein of unknown function (DUF1344)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.2   0.00095       4.3      10      28 ..      22      40 ..      21      45 .. 0.82
   2 ?    1.8   0.0     0.052   2.4e+02      18      34 ..      75      91 ..      70      92 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00095
     DUF1344 10 kidkkalsitLdDGktYkl 28
                +i +++ sitL+DG +  +
  EFC39445.1 22 SILAQTCSITLSDGTSIDV 40
                6778999*******87665 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.052
     DUF1344 18 itLdDGktYklpeefdi 34
                + L DG+ ++ ++++++
  EFC39445.1 75 VCLVDGQAFQYSNDINL 91
                5789**********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (266 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       806  (0.0449551); expected 358.6 (0.02)
Passed bias filter:                      616  (0.0343577); expected 358.6 (0.02)
Passed Vit filter:                        67  (0.00373696); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.42
# Mc/sec: 1892.50
//
Query:       EFC39446.1  [L=1308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.5e-17   61.8  17.0    3.9e-07   30.0   0.3    5.7  6  Kelch_4    Galactose oxidase, central domain
    3.6e-16   59.4   0.6    1.1e-14   54.7   0.0    3.0  2  BTB        BTB/POZ domain
    2.9e-14   52.9   4.4    6.7e-06   26.3   0.1    5.3  5  Kelch_3    Galactose oxidase, central domain
    5.9e-12   45.0   7.0    1.1e-06   28.1   0.1    4.3  5  Kelch_1    Kelch motif
    3.9e-11   43.3   0.8    3.9e-11   43.3   0.8    2.5  2  RWD        RWD domain
    1.3e-10   40.8   5.5    1.5e-05   24.8   0.1    3.9  4  Kelch_2    Kelch motif
    3.4e-10   39.7  10.5    0.00013   21.8   0.0    4.8  5  Kelch_5    Kelch motif
    1.6e-07   31.4  13.4     0.0035   17.6   0.2    5.3  6  Kelch_6    Kelch motif


Domain annotation for each model (and alignments):
>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.3      0.34   7.6e+02       2      35 ..     549     581 ..     548     581 .. 0.88
   2 !   13.2   0.1   2.9e-05     0.066       1      35 [.     597     632 ..     597     637 .. 0.91
   3 !   23.8   0.1   1.4e-08   3.2e-05       3      49 .]     651     705 ..     650     705 .. 0.92
   4 !   30.0   0.3   1.7e-10   3.9e-07       2      45 ..     707     751 ..     706     755 .. 0.89
   5 ?    1.9   0.1       0.1   2.2e+02       5      41 ..     759     795 ..     756     801 .. 0.74
   6 ?   -1.7   0.0       1.3     3e+03       9      26 ..     814     834 ..     810     839 .. 0.60

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.34
     Kelch_4   2 RaghsatsipdgtiylfGGrgedgtllndlylld 35 
                 R gh++ s+++   + fGG+ e g + +dl  ++
  EFC39446.1 549 RYGHAVASNGNHLWFSFGGIHE-GRVTADLISFN 581
                 889999999999999*******.59999998876 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 2.9e-05
     Kelch_4   1 pRaghsatsi.pdgtiylfGGrgedgtllndlylld 35 
                 pR++h++t+i     +++ GG +e+   ++d+yl+d
  EFC39446.1 597 PRIFHTFTYIvTAEIFVILGGMSENRDYYSDAYLID 632
                 9*********766899999******99*******98 PP

  == domain 3  score: 23.8 bits;  conditional E-value: 1.4e-08
     Kelch_4   3 aghsatsipdgtiylfGGrgedgtllndlyll........dlstntWrrl..gslPs 49 
                 aghsat    +++y+fGG ++d t +n+ly l        ++++n+W r+  ++ Ps
  EFC39446.1 651 AGHSATNF-EDKLYVFGGFSGD-TYSNHLYSLtlrkpkigNAPSNSWIRIdaPNGPS 705
                 79******.69**********9.9********9**************9998777675 PP

  == domain 4  score: 30.0 bits;  conditional E-value: 1.7e-10
     Kelch_4   2 RaghsatsipdgtiylfGGrgedgtllndlylldlstntWrrl...g 45 
                 R+g+s+++  ++ +y++GG +  g++l+dly++dl  + W+++   g
  EFC39446.1 707 RCGCSSVVF-RDILYVYGGNNK-GAFLDDLYAFDLNLKYWTKIvtfG 751
                 9********.69*******999.69****************986554 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.1
     Kelch_4   5 hsatsipdgtiylfGGrgedgtllndlyl.ldlstntW 41 
                 ++++++ ++t+ l+GG++      n + l +++ + tW
  EFC39446.1 759 AQLFATANNTLTLIGGIYVY-RNWNTTVLeFSIDSSTW 795
                 56899999********9973.56666655566666665 PP

  == domain 6  score: -1.7 bits;  conditional E-value: 1.3
     Kelch_4   9 si..pd.gtiylfGGrgedg.t 26 
                 s+  ++ + iy +GG+ + g t
  EFC39446.1 814 SVlqDNqNFIY-TGGIKNLGfT 834
                 33333325666.***9988744 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1      0.14   3.2e+02      68     107 ..     980    1022 ..     906    1026 .. 0.86
   2 !   54.7   0.0   4.7e-18   1.1e-14      21     108 ..    1153    1239 ..    1144    1242 .. 0.93

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.14
                  HHHHHHSEEEC-...CGGGHHHHHHHHHHHT-HHHHHHHHHHH CS
         BTB   68 LefiYtgeleit...seenleelLaaadllqiprlkkaceefl 107 
                  L+f+Y+  ++ +   ++++  el +aa+++++  l +++++ +
  EFC39446.1  980 LQFVYSYSFDPElvrTDKECLELYQAAKKFKLTLLCEMLCNSI 1022
                  899999999999999899*************999888777666 PP

  == domain 2  score: 54.7 bits;  conditional E-value: 4.7e-18
                  EEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHHHHHHHHHHH CS
         BTB   21 kefkahkavLaarSpyFkalftskeieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprlkkaceeflk 108 
                  k + +hk +L  rS++F+++f+ + ++es+++ei+l+d + +++ea+L ++Y+g++++  +en+ el+ aa+ +++p++ + + +f++
  EFC39446.1 1153 KYIIVHKSILVYRSKFFRTMFNMD-FSESKTNEIRLNDTSMQSIEAILYWMYSGKFPTILSENAIELFVAASQYDLPEVRDWARSFIE 1239
                  66889*******************.9******************************98878******************998888876 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.82   1.8e+03      37      49 .]     594     606 ..     563     606 .. 0.61
   2 ?    4.8   0.0     0.016        36       5      47 ..     613     656 ..     612     657 .. 0.86
   3 !   26.3   0.1     3e-09   6.7e-06       1      49 []     659     715 ..     659     715 .. 0.88
   4 !   17.5   0.1   1.6e-06    0.0036       4      36 ..     719     752 ..     717     765 .. 0.86
   5 ?    0.2   0.1      0.45     1e+03      19      32 ..     783     796 ..     766     805 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.82
     Kelch_3  37 lppaRaghaatai 49 
                 +  +R +h+ t+i
  EFC39446.1 594 TINPRIFHTFTYI 606
                 4449999999987 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.016
     Kelch_3   5 yifGGlgddgqdrlndvyvydldtn..tWaeiaslppaRaghaat 47 
                 +i GG    ++d+++d y++d + n  ++++++  p+  agh+at
  EFC39446.1 613 VILGGMS-ENRDYYSDAYLIDCQFNhpNVQRLPVFPSKIAGHSAT 656
                 6778888.79**********7755555***************997 PP

  == domain 3  score: 26.3 bits;  conditional E-value: 3e-09
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydl........dtntWaei..aslppaRaghaatai 49 
                 +d+ly+fGG+   g +++n +y++ l         +n+W +i  ++ p+ R+g +++++
  EFC39446.1 659 EDKLYVFGGFS--GDTYSNHLYSLTLrkpkignaPSNSWIRIdaPNGPSRRCGCSSVVF 715
                 589********..*************77777655556*****99999******999875 PP

  == domain 4  score: 17.5 bits;  conditional E-value: 1.6e-06
     Kelch_3   4 lyifGGlgddgqdrlndvyvydldtntWaei...as 36 
                 ly++GG++   + +l d+y++dl+  +W++i   ++
  EFC39446.1 719 LYVYGGNN--KGAFLDDLYAFDLNLKYWTKIvtfGT 752
                 8*******..*******************9866644 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.45
     Kelch_3  19 ndvyvydldtntWa 32 
                  +v+++++d+ tW 
  EFC39446.1 783 TTVLEFSIDSSTWS 796
                 6899*********7 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       1.6   3.5e+03       2      14 ..     549     561 ..     548     580 .. 0.86
   2 ?   -0.3   0.0      0.36     8e+02      15      37 ..     613     636 ..     607     637 .. 0.87
   3 !   16.7   0.0   1.8e-06    0.0041       3      35 ..     651     683 ..     650     698 .. 0.79
   4 !   28.1   0.1   4.8e-10   1.1e-06       1      42 [.     706     747 ..     706     750 .. 0.96
   5 ?   -0.6   0.1      0.47     1e+03      16      42 ..     771     798 ..     762     799 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.6
                 BBSEEEEEETTEE CS
     Kelch_1   2 ragagavvvggki 14 
                 r+g+++++ g+++
  EFC39446.1 549 RYGHAVASNGNHL 561
                 8999999999987 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.36
                 EEEEEBCS.SSBEEEEEEEETTTT CS
     Kelch_1  15 YviGGsdg.gnalssvevyDpetn 37 
                  ++GG+++   + s+++ +D+  n
  EFC39446.1 613 VILGGMSEnRDYYSDAYLIDCQFN 636
                 5789***999**********9876 PP

  == domain 3  score: 16.7 bits;  conditional E-value: 1.8e-06
                 BSEEEEEETTEEEEEEEBCSSSBEEEEEEEETT CS
     Kelch_1   3 agagavvvggkiYviGGsdggnalssvevyDpe 35 
                 ag++a+ + +k+Yv+GG++g ++++ ++ + ++
  EFC39446.1 651 AGHSATNFEDKLYVFGGFSGDTYSNHLYSLTLR 683
                 689*****************9999988887777 PP

  == domain 4  score: 28.1 bits;  conditional E-value: 4.8e-10
                 BBBSEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEEE CS
     Kelch_1   1 aragagavvvggkiYviGGsdggnalssvevyDpetntWrel 42 
                 +r+g+++vv+++ +Yv GG + g +l++++++D+  + W+++
  EFC39446.1 706 RRCGCSSVVFRDILYVYGGNNKGAFLDDLYAFDLNLKYWTKI 747
                 7*************************************9986 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 0.47
                 EEEEBCS.SSBEEEEEEEETTTTEEEEE CS
     Kelch_1  16 viGGsdg.gnalssvevyDpetntWrel 42 
                  iGG     n   +v  ++  + tW+ l
  EFC39446.1 771 LIGGIYVyRNWNTTVLEFSIDSSTWSAL 798
                 58888888899999999********976 PP

>> RWD  RWD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.3   0.8   1.7e-14   3.9e-11       3     115 ..     291     436 ..     290     437 .. 0.84
   2 ?   -3.6   0.1         6   1.4e+04      29      62 ..     484     533 ..     467     537 .. 0.56

  Alignments for each domain:
  == domain 1  score: 43.3 bits;  conditional E-value: 1.7e-14
                 HHHHHHHHHHHSTTTCCCCH...T--EE--S-EEEEEEECECCCC...........TT-CEEEEEEEEE-SSTT.......SS--EEEEEECC...... CS
                 xxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxxxxxxxx.......xxxxxxxxxxxx...... RF
         RWD   3 qeqEleaLesIypdefevie...nenysikleikikldededeedse.......feekkkpslkleiklpeeYP.......eeaPiislsste...... 78 
                 ++qE+e+L+sIy+++f  i+     + +i+ +++++l +d+d  +++       f+ +  + lkl +k+ + YP       + +P i l+         
  EFC39446.1 291 RSQEIEVLQSIYGEDFAMIDaeqCFEITIRGKLNFELPSDSDIANNHfsiseipFKLS-HVGLKLWVKYVNGYPsqtlpkfKCIPLIDLNRIMslvrsa 388
                 79**************777763444455566777777777777777788888755555.588*************999999999999998888999999 PP

                 ...........SS-HHHHHHHHHHHHHHHHHTTTS--CHHHHHHHHHH CS
                 ...........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         RWD  79 ...........nlpkeqvksleekleelaeenlgepvifalidwlken 115
                            ++++e+++s+  k++ + +e lg ++++++i++++e 
  EFC39446.1 389 sqvhaqlslksQMQEEEIESIYAKIRAKSSELLGYAMVYSFIQEIEEY 436
                 99999999999999*******************************997 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 6
                 -S-EEEEEEECECCCC....................TT-CEEEEEEEEE- CS
                 xxxxxxxxxxxxxxxxxx................xxxxxxxxxxxxxxxx RF
         RWD  29 kleikikldededeedse................feekkkpslkleiklp 62 
                 +++ k+k +e+ +eed +                f+ k+  s++  +k+ 
  EFC39446.1 484 ETSAKYKNKENHEEEDRKkkgctknnavweniqyFKAKNRISIESYVKVE 533
                 34444444444444443355666666666666666666666666555555 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.22   4.9e+02       2      21 ..     549     569 ..     548     589 .. 0.80
   2 !   15.0   0.0   8.2e-06     0.018       3      33 ..     651     678 ..     650     697 .. 0.82
   3 !   24.8   0.1   6.5e-09   1.5e-05       1      44 [.     706     746 ..     706     747 .. 0.97
   4 ?   -2.6   0.1       2.9   6.6e+03      13      45 ..     774     798 ..     769     800 .. 0.66

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.22
     Kelch_2   2 rgghsss.vpggkiyvvGGah 21 
                 r+gh+++  +++  +++GG+h
  EFC39446.1 549 RYGHAVAsNGNHLWFSFGGIH 569
                 899999956688889999993 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 8.2e-06
     Kelch_2   3 gghsssvpggkiyvvGGahtdnpnlsssdvh 33 
                 +ghs++  ++k+yv+GG+    ++ +s++++
  EFC39446.1 651 AGHSATNFEDKLYVFGGF---SGDTYSNHLY 678
                 69****************...7777776664 PP

  == domain 3  score: 24.8 bits;  conditional E-value: 6.5e-09
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44 
                 rr+g+ss+v ++ +yv+GG    n++ + +d++ +dl+ + W++
  EFC39446.1 706 RRCGCSSVVFRDILYVYGGN---NKGAFLDDLYAFDLNLKYWTK 746
                 79******************...*******************97 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 2.9
     Kelch_2  13 kiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                  iyv+  +          +v  +  ++ +W+ +
  EFC39446.1 774 GIYVYRNW--------NTTVLEFSIDSSTWSAL 798
                 56666666........55667777777777755 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.2     0.043        97       5      34 ..     549     577 ..     548     582 .. 0.71
   2 ?    0.0   0.1       0.4   8.9e+02       5      35 ..     598     629 ..     596     632 .. 0.73
   3 !   21.8   0.0     6e-08   0.00013       1      39 [.     646     682 ..     646     685 .. 0.91
   4 !   17.2   0.2   1.6e-06    0.0036       3      39 ..     704     739 ..     704     740 .. 0.90
   5 ?   -3.2   0.0       4.2   9.4e+03       5      24 ..     809     829 ..     809     833 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.043
     Kelch_5   5 Raghcavtvs.ekiYvyGGkvgrdgsvsddv 34 
                 R+gh+++  + + ++ +GG+   +g v+ d+
  EFC39446.1 549 RYGHAVASNGnHLWFSFGGIH--EGRVTADL 577
                 777777777635555588888..88888776 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.4
     Kelch_5   5 Raghcavt.vsekiYv.yGGkvgrdgsvsddvy 35 
                 R  h + + v  +i+v  GG++ ++ ++++d+y
  EFC39446.1 598 RIFHTFTYiVTAEIFViLGGMS-ENRDYYSDAY 629
                 555555542566777768****.8999999999 PP

  == domain 3  score: 21.8 bits;  conditional E-value: 6e-08
     Kelch_5   1 iPppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdl 39 
                 +P+ +agh+a   ++k+Yv+GG++g  + +s+++y L+l
  EFC39446.1 646 FPSKIAGHSATNFEDKLYVFGGFSG--DTYSNHLYSLTL 682
                 59999*******************6..********8877 PP

  == domain 4  score: 17.2 bits;  conditional E-value: 1.6e-06
     Kelch_5   3 ppRaghcavtv.sekiYvyGGkvgrdgsvsddvyvLdl 39 
                 p+R+++c+ +v  + +YvyGG +   g + dd+y +dl
  EFC39446.1 704 PSRRCGCSSVVfRDILYVYGGNN--KGAFLDDLYAFDL 739
                 68******77659**********..99999****9998 PP

  == domain 5  score: -3.2 bits;  conditional E-value: 4.2
     Kelch_5   5 Raghcavt.vsekiYvyGGkv 24 
                 R+  c+v  ++++ +++GG++
  EFC39446.1 809 RTALCSVLqDNQNFIYTGGIK 829
                 677799994457778888865 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.2     0.063   1.4e+02       2      34 ..     549     581 ..     548     584 .. 0.90
   2 ?   -3.6   0.0       7.6   1.7e+04      15      35 ..     613     633 ..     612     634 .. 0.74
   3 !   13.2   0.0   3.8e-05     0.085       3      24 ..     651     679 ..     650     704 .. 0.69
   4 !   17.6   0.2   1.6e-06    0.0035       2      43 ..     707     747 ..     706     752 .. 0.95
   5 ?    2.9   0.1     0.065   1.5e+02       7      42 ..     762     797 ..     757     799 .. 0.86
   6 ?   -2.7   0.0       3.9   8.7e+03       7      31 ..     814     840 ..     809     845 .. 0.55

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.063
     Kelch_6   2 raghslvsvggki.YifGGytdsspylnkvwvyd 34 
                 r+gh+++s g+++ + fGG    +  + +++ ++
  EFC39446.1 549 RYGHAVASNGNHLwFSFGGIHE-GRVTADLISFN 581
                 889**********9999***99.89999998887 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 7.6
     Kelch_6  15 YifGGytdsspylnkvwvydp 35 
                 +i+GG +    y+++ +++d+
  EFC39446.1 613 VILGGMSENRDYYSDAYLIDC 633
                 678888766788888888886 PP

  == domain 3  score: 13.2 bits;  conditional E-value: 3.8e-05
     Kelch_6   3 aghslvsvggkiYifGGytds.......s 24 
                 aghs++   +k+Y+fGG +++       s
  EFC39446.1 651 AGHSATNFEDKLYVFGGFSGDtysnhlyS 679
                 589****************9655555553 PP

  == domain 4  score: 17.6 bits;  conditional E-value: 1.6e-06
     Kelch_6   2 raghslvsvggkiYifGGytdsspylnkvwvydpetksWeql 43 
                 r+g+s+v+  + +Y++GG++  + +l++++ +d+  k W+++
  EFC39446.1 707 RCGCSSVVFRDILYVYGGNNK-GAFLDDLYAFDLNLKYWTKI 747
                 9********************.9****************987 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.065
     Kelch_6   7 lvsvggkiYifGGytdsspylnkvwvydpetksWeq 42 
                 ++++++++ ++GG + + ++   v+ +++++ +W+ 
  EFC39446.1 762 FATANNTLTLIGGIYVYRNWNTTVLEFSIDSSTWSA 797
                 689***********9998999999999***999985 PP

  == domain 6  score: -2.7 bits;  conditional E-value: 3.9
     Kelch_6   7 lvs.vggkiYifGGytds.spylnkvw 31 
                 +v+  +  + + GG ++  +++l k+ 
  EFC39446.1 814 SVLqDNQNFIYTGGIKNLgFTSLAKIS 840
                 444144355666666665577777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1650  (0.0920297); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.00u 0.31s 00:00:01.31 Elapsed: 00:00:00.52
# Mc/sec: 7572.61
//
Query:       EFC39447.1  [L=149]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.03   14.7   1.1        2.4    8.6   0.2    2.4  2  FlaC_arch  Flagella accessory protein C (FlaC)


Domain annotation for each model (and alignments):
>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0    0.0026        46       1      27 [.      83     109 ..      77     113 .. 0.88
   2 ?    8.6   0.2   0.00013       2.4      18      40 ..     123     145 ..     119     146 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0026
   FlaC_arch   1 ridelEnklsklsteletvkkeneels 27 
                 +i  l++++   +++ +t +++  +++
  EFC39447.1  83 KIHILQQEIHAAESKASTYRAQAAKIK 109
                 677899999999999999999999887 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00013
   FlaC_arch  18 tvkkeneelsksveelkenVkdl 40 
                 t ++e +el+  ++elk+nV+dl
  EFC39447.1 123 TYESETKELEMHLKELKKNVQDL 145
                 789999**************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1326  (0.0739584); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.26s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 1012.42
//
Query:       EFC39448.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.6e-09   36.9   0.1     0.0008   19.0   0.0    2.2  2  Esterase_phd   Esterase PHB depolymerase
    0.00083   19.1   0.1      0.017   14.7   0.1    2.3  2  Esterase       Putative esterase
    0.00099   19.0   0.0     0.0015   18.4   0.0    1.4  1  Abhydrolase_2  Phospholipase/Carboxylesterase


Domain annotation for each model (and alignments):
>> Esterase_phd  Esterase PHB depolymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.0   1.3e-06    0.0079     100     147 ..      73     120 ..      67     132 .. 0.89
   2 !   19.0   0.0   1.3e-07    0.0008      15      55 ..     290     330 ..     275     339 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 1.3e-06
  Esterase_phd 100 yvaGlsaGaaladllalhypdvfaavalhsGlalGeaadvisaldvmr 147
                    v+G+ aGa++a ++   + ++   va  sGl++ + ++ +s l++  
    EFC39448.1  73 TVSGFGAGASMAIMMQVAHSQKVGGVASFSGLPYYCVKNNMSRLETCF 120
                   699***********************************9999988765 PP

  == domain 2  score: 19.0 bits;  conditional E-value: 1.3e-07
  Esterase_phd  15 amplvvmlhGctqsveefaaGtrmnlladklGvvvlypeqs 55 
                   +  + v +hGc q+ +ef   +  n +a++  +vvlyp  +
    EFC39448.1 290 CKHIHVAFHGCDQTGDEFPLYSGYNRIAEQNNIVVLYPRTA 330
                   4567899*******************************876 PP

>> Esterase  Putative esterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.1   2.9e-06     0.017     117     205 ..      72     174 ..      57     183 .. 0.78
   2 ?    1.6   0.0     0.029   1.7e+02      12      64 ..     277     327 ..     275     337 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 2.9e-06
                 EEEEEETHHHHHHHHHHHCSTTTCCEEEEES--S-CC.............HCHHHC......TTCCHHHCC-CCCCHCHHCHTTSEEEEEEEECTTBCC CS
    Esterase 117 ravaGqSmGGlgALilalkhpdrFgsvssfSpivnps.............namWgq......eekeawqendpvllakelsaslkalriyldvGtsedd 196
                  +v G+  G+++A+++ + h ++ g v+sfS++ + +                  +      e  e + +   + l+++  ++l+  +iyl++G++++ 
  EFC39448.1  72 LTVSGFGAGASMAIMMQVAHSQKVGGVASFSGLPYYCvknnmsrletcfkH----TekipmsEFMEMFDKFIYFNLIDN-LDHLPSHKIYLQSGSKDKS 165
                 6899****************************9666688777777655550....155544456677777777777765.8999999***********9 PP

                 CHTSCHHHH CS
    Esterase 197 lgeqlsvei 205
                 l++q + + 
  EFC39448.1 166 LTQQAALKS 174
                 998877665 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.029
                 EEE.CC...GGTTTEEEEEEE--TTHHCCHHHHHCHHCCCCHCCT.EEEEEECCC CS
    Esterase  12 vyLPedy..spgrkypvvylldGltgwdqnfrakelleslaregeiaeviivvvp 64 
                 +y P+    ++++  +  ++++G + + ++f+  +++++ a+++     i+v  p
  EFC39448.1 277 IYIPSACqkDETKCKHIHVAFHGCDQTGDEFPLYSGYNRIAEQN----NIVVLYP 327
                 67777766445555577799*****************9988887....4555555 PP

>> Abhydrolase_2  Phospholipase/Carboxylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   2.5e-07    0.0015     105     140 ..      70     105 ..      46     181 .. 0.79

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 2.5e-07
                    GGEEEEEETHHHHHHHHHHHT-SS--SEEEEES--- CS
  Abhydrolase_2 105 sriiigGFSqGaalalylaltlpkklggivafsgal 140
                    ++  + GF+ Ga +a+   ++ ++k+gg+ +fsg  
     EFC39448.1  70 KNLTVSGFGAGASMAIMMQVAHSQKVGGVASFSGLP 105
                    567789****************************63 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      506  (0.0282224); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.28s 00:00:00.77 Elapsed: 00:00:00.41
# Mc/sec: 2460.34
//
Query:       EFC39449.1  [L=716]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-08   34.8   8.7    1.3e-08   34.8   8.7    2.9  3  zf-B_box    B-box zinc finger
    1.5e-08   34.8   0.1    1.5e-08   34.8   0.1    2.3  3  MATH        MATH domain
    2.4e-07   30.5  13.1    2.4e-07   30.5  13.1    2.4  2  zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
    0.00086   19.1   7.1     0.0028   17.5   7.1    1.9  1  DUF1351     Protein of unknown function (DUF1351)
     0.0065   16.8  17.0     0.0065   16.8  17.0    2.4  2  zf-RING_2   Ring finger domain


Domain annotation for each model (and alignments):
>> zf-B_box  B-box zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.7   8.0         5   1.8e+04       4      29 ..     130     156 ..     127     161 .. 0.74
   2 ?   -1.0   0.1      0.59   2.1e+03       3      13 ..     164     173 ..     162     176 .. 0.58
   3 !   34.8   8.7   3.6e-12   1.3e-08       4      41 ..     215     253 ..     213     254 .. 0.94

  Alignments for each domain:
  == domain 1  score: -5.7 bits;  conditional E-value: 5
    zf-B_box   4 tkCpeHknkpat.lfCedCqqplCeeC 29 
                  kC  + nkp +   C  C++ +C  C
  EFC39449.1 130 VKCFLCFNKPSSpHLCPCCSKIVCLGC 156
                 578888876555367999999999999 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.59
    zf-B_box   3 etkCpeHknkp 13 
                 +  Cp++  +p
  EFC39449.1 164 KSSCPNCR-SP 173
                 45566665.44 PP

  == domain 3  score: 34.8 bits;  conditional E-value: 3.6e-12
    zf-B_box   4 tkCpeHknkpatlfCedCqqplCeeC..stgeHrgHevvp 41 
                   C  H+  p++++Ce+C++p+C++C   +++H++H++++
  EFC39449.1 215 EHCSSHD-LPLIYYCETCKEPICSDCamFEEKHKNHKFKK 253
                 57*****.*****************************987 PP

>> MATH  MATH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.1       4.5   1.6e+04      73      96 ..     246     258 ..     240     272 .. 0.52
   2 !   34.8   0.1   4.2e-12   1.5e-08       1     105 [.     405     517 ..     405     523 .. 0.85
   3 ?   -2.7   0.0       1.8   6.4e+03      89     108 ..     602     621 ..     575     649 .. 0.56

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 4.5
        MATH  73 kdthkfekekgwgwgkfiswdkle 96 
                 +++hkf+k            ++++
  EFC39449.1 246 HKNHKFKK-----------VNEVY 258
                 22244443...........33333 PP

  == domain 2  score: 34.8 bits;  conditional E-value: 4.2e-12
        MATH   1 iknfSklk.egesryskveerfnipWrlkikrkng......flglyLrcnkeeelerkwsieveftlklvssngksvkkkdthkfekekgwgwgkfisw 92 
                 i+n+S+l  + e  ys+++++ +++Wrlk++++++      f++++L++ k   l+   +  +++++  + +++k+++++    fe+ ++wg+++f + 
  EFC39449.1 405 IENYSELLkTTEVIYSDPITINGLQWRLKVYPNGTgvakgvFISVFLEMFKG--LTEPKKYHYKVEMVNKRDTSKNIERSFASIFESGECWGYNRFYRV 501
                 6789998735666677************************************..5546899999999999999999**********************9 PP

        MATH  93 dklekky...lvdDsi 105
                 ++l  +    ++dD +
  EFC39449.1 502 SELAGNGfidVDDDVL 517
                 9997544366666665 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 1.8
        MATH  89 fiswdklekkylvdDsiive 108
                 + + ++   k+ +d+s+ ++
  EFC39449.1 602 VQEQENTSLKIEEDNSFSIN 621
                 33333333333333333333 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.5  13.1   6.8e-11   2.4e-07       3      48 ..     130     175 ..     128     177 .. 0.95
   2 ?   -1.8   2.8      0.83     3e+03      25      33 ..     227     235 ..     215     248 .. 0.66

  Alignments for each domain:
  == domain 1  score: 30.5 bits;  conditional E-value: 6.8e-11
                 SB-TTTSSSBS-EEETTEEEEEE-HHHHHHHHHTT-B-TTT--B-- CS
  zf-C3HC4_3   3 eeCviClerprnvvllpCgHlvlCeeCaekllkrkkkCpiCrrpie 48 
                  +C +C+++p++  l+pC+  ++C  Ca+k+ ++k +Cp Cr+p +
  EFC39449.1 130 VKCFLCFNKPSSPHLCPCCSKIVCLGCAKKWISEKSSCPNCRSPLS 175
                 58*****************************************986 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.83
                 E-HHHHHHH CS
  zf-C3HC4_3  25 lCeeCaekl 33 
                 +Ce+C e +
  EFC39449.1 227 YCETCKEPI 235
                 455555544 PP

>> DUF1351  Protein of unknown function (DUF1351)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   7.1   7.7e-07    0.0028      86     203 ..     229     374 ..     185     378 .. 0.64

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 7.7e-07
     DUF1351  86 keaidkideqikefeekekeekkkevkaliselaeeaeveleeieiqekwln................ktvslkkieeei.eaa.kaekikkdre..el 164
                 +   ++i ++   feek k+ k+k+v++ ++e ++  +ve e+++ + k ln                k  +lk+i+e + e    ++ + k  +  +l
  EFC39449.1 229 ETCKEPICSDCAMFEEKHKNHKFKKVNEVYKECVDIVKVESETVKTRLKDLNsltlsieenikritkaKEETLKTINETVeEMRtNLDSLYKS-KlsSL 326
                 5566789999999*******************************9999988865555555555555556666666666662111011111111.12344 PP

     DUF1351 165 ekakaeieekaka.........feleasaylrllkegkslsdvlkqid 203
                  ++k+ i+++++           ++e s+   l++++ ++++v+ +i+
  EFC39449.1 327 VSQKNMIIDEIAMlekltkelgRQIETSPQCVLISKTPDIVRVVDEIN 374
                 444444444444456666666666666666666666666666666666 PP

>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8  17.0   1.8e-06    0.0065       2      44 .]     131     171 ..     130     171 .. 0.80
   2 ?   -2.8   3.4       2.4   8.5e+03      18      30 ..     228     240 ..     211     250 .. 0.67

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 1.8e-06
   zf-RING_2   2 eCpICleelssadsvlllpCg.HvfhreClerwlrssstCPlCr 44 
                 +C +C+   ++++s++l+pC+ ++ +  C+++w+ ++s+CP+Cr
  EFC39449.1 131 KCFLCF---NKPSSPHLCPCCsKIVCLGCAKKWISEKSSCPNCR 171
                 699997...5555566666662679******************9 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.4
   zf-RING_2  18 llpCgHvfhreCl 30 
                 ++ C+  ++ +C+
  EFC39449.1 228 CETCKEPICSDCA 240
                 2347666777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (716 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1823  (0.101679); expected 358.6 (0.02)
Passed bias filter:                      504  (0.0281109); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.45
# Mc/sec: 4795.26
//
Query:       EFC39450.1  [L=1483]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.7e-46  158.1   0.2    5.7e-46  157.0   0.2    1.4  1  Pkinase        Protein kinase domain
    6.4e-36  124.0   0.2    7.3e-34  117.2   0.2    2.2  1  Pkinase_Tyr    Protein tyrosine kinase
    1.1e-24   85.1  16.3    2.7e-05   24.0   0.3   11.1 11  NHL            NHL repeat
    5.8e-07   29.8  55.4     0.0034   17.7  10.0    4.7  4  EGF_2          EGF-like domain
    0.00029   19.9   0.2    0.00063   18.8   0.2    1.5  1  Haspin_kinase  Haspin like kinase domain
     0.0013   19.0  31.3       0.13   12.6   3.3    4.0  3  EGF            EGF-like domain
     0.0027   17.3   0.1        1.4    8.4   0.0    4.2  4  SGL            SMP-30/Gluconolactonase/LRE-like region
     0.0055   15.8   0.1      0.011   14.8   0.1    1.4  1  Seadorna_VP7   Seadornavirus VP7
  ------ inclusion threshold ------
      0.068   13.1   0.2       0.14   12.1   0.2    1.4  1  TMEM154        TMEM154 protein family
      0.099   11.9   0.0       0.16   11.2   0.0    1.2  1  Kinase-like    Kinase-like
       0.17   11.7   0.1       0.35   10.7   0.1    1.4  1  APH            Phosphotransferase enzyme family
       0.19   11.7   0.5       0.47   10.5   0.5    1.6  1  SLIDE          SLIDE
          1    9.5  33.6       0.92    9.6   1.3    4.0  3  EGF_Tenascin   Tenascin EGF domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  157.0   0.2   4.1e-49   5.7e-46       4     260 ..    1180    1473 ..    1178    1475 .. 0.85

  Alignments for each domain:
  == domain 1  score: 157.0 bits;  conditional E-value: 4.1e-49
                  EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH..HHSS..-- CS
     Pkinase    4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle..rkgs..ls 96  
                  +++lGeG++G+V+  +   +g ++AvK+++ ++ + ++ +++  E  +l kl+hpni+++y++ ++++++++ +e+++ ++l+++++  +kg+   s
  EFC39450.1 1180 IKRLGEGGMGSVFMTK--YNGMKIAVKVFDLNNFNISE-DDFKIEAILLSKLRHPNIINFYGISSTPTKRFIAMECMD-KSLESMISslQKGTstCS 1272
                  689**********999..8************9988777.59*************************************.569999998744432233 PP

                  HHHHH.HHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH...TTSCBSHHHHHHHHH CS
     Pkinase   97 eeeak.kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl...keneyskkvDvWslG 184 
                    ++k +i+ ++++g++ylH+ +   iiHrDlKp+NiL+d++g  K++DFGl + l+s++    ts vgt +Y++PE+     e++  +++D++sl+
  EFC39450.1 1273 L-KMKlSIILNVVSGINYLHHLEpnfIIHRDLKPANILLDKNGIAKLCDFGLGRALSSNTVsaITSKVGTYNYMSPELFsddIERGDARSIDIYSLA 1368
                  3.44459*************876677*******************************998789****************6543467799******** PP

                  HHHHHHHHS.S-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS...................................-HHHHHHHHHHT CS
     Pkinase  185 vilyelltg.kppfsgekgkekvekeldqlekilkilgetkeklpeasei...................................seeakdllkkll 245 
                  +il++l+++  +p++++++k  ++ +l++     k   + + +++ +++i                                     e+ +l+++ +
  EFC39450.1 1369 IILWQLVFEiMEPYQSSDTKVLQKLNLEK----PK---TFNSTYHFHKSIceeklrpiipfstleecrewcekfldqeqakyyevIYEMSQLIEQSW 1458
                  ******99835699977777777777777....22...223344444454555567788999999*******************99*********** PP

                  -SSGCCSTTHHHHHT CS
     Pkinase  246 kkdpkkRltaeellq 260 
                  + +p+kR+t  ++l+
  EFC39450.1 1459 SHEPSKRPTSVQILE 1473
                  **********99987 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.2   0.2   5.3e-37   7.3e-34       5     258 ..    1181    1474 ..    1178    1475 .. 0.87

  Alignments for each domain:
  == domain 1  score: 117.2 bits;  conditional E-value: 5.3e-37
                   EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTE..BHHHHHHHTCTT CS
  Pkinase_Tyr    5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgG..dLlkfLrkkeke 98  
                   k+lGeG  G+V++ +++       +k+avK+++ ++ + +++++  ea +++kl+hpni++++g+ +   + +i +e +++   ++ + L+k  ++
   EFC39450.1 1181 KRLGEGGMGSVFMTKYN------GMKIAVKVFDLNNFNISEDDFKIEAILLSKLRHPNIINFYGISSTPTKRFIAMECMDKSleSMISSLQKG-TS 1269
                   89***************......9********99999999***************************99**********98766899999998.99 PP

                   TSBHHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE...EEHHHHH CS
  Pkinase_Tyr   99 kltlkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk...ftsksDv 188 
                   +++lk +ls++l+v +G++yL++ +   ++Hrdl   N+Ll++n ++k++DfGL r++ ++++ ++ +++   +++m+pE +++        + D+
   EFC39450.1 1270 TCSLKMKLSIILNVVSGINYLHHLEpnfIIHRDLKPANILLDKNGIAKLCDFGLGRAL-SSNTVSAITSKVGTYNYMSPELFSDDIergDARSIDI 1364
                   ********************998665669*****************************.66667788888999**********99866555667** PP

                   HHHHHHHHHHHTTSSGT........................................TTTS.HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT- CS
  Pkinase_Tyr  189 WsfGvllwEiftlgesp........................................ypgl.kneevleklkegkrlekpekcpeelyelmkkcwe 243 
                   +s +++lw ++    +p                                        +++l + +e +ek+ ++++ +  e +  e+ +l++++w+
   EFC39450.1 1365 YSLAIILWQLVFEIMEPyqssdtkvlqklnlekpktfnstyhfhksiceeklrpiipFSTLeECREWCEKFLDQEQAKYYE-VIYEMSQLIEQSWS 1459
                   ************9999*8888888888888888888888888888888888888877666655566777777777666655.67788888888888 PP

                   SSGGGS--HHHHHHH CS
  Pkinase_Tyr  244 edpeeRptfselvek 258 
                   ++p++Rpt  +++ek
   EFC39450.1 1460 HEPSKRPTSVQILEK 1474
                   888888888887765 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.4   1.9e+03      17      28 .]     111     123 ..     110     123 .. 0.90
   2 ?    1.6   0.0      0.23   3.2e+02       5      17 ..     188     200 ..     184     204 .. 0.89
   3 ?    0.7   0.0      0.45   6.2e+02      16      25 ..     490     499 ..     490     500 .. 0.90
   4 ?    0.7   0.0      0.46   6.3e+02       2      13 ..     520     531 ..     520     543 .. 0.72
   5 !   14.9   0.1   1.5e-05      0.02       1      25 [.     576     599 ..     576     600 .. 0.94
   6 !   24.0   0.3     2e-08   2.7e-05       1      27 [.     632     657 ..     632     658 .. 0.96
   7 ?    1.0   0.0      0.38   5.2e+02       1      18 [.     688     704 ..     688     710 .. 0.87
   8 !    8.7   0.0    0.0014       1.9       1      26 [.     724     748 ..     724     750 .. 0.94
   9 !   10.3   0.0   0.00041      0.56       6      25 ..     779     798 ..     776     801 .. 0.85
  10 !    9.3   0.1   0.00089       1.2       2      27 ..     830     856 ..     829     857 .. 0.88
  11 !   11.7   0.0   0.00015       0.2       4      27 ..     936     959 ..     934     960 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.4
                 EEE.CCCTEEEEE CS
         NHL  17 VaD.senhrvqvF 28 
                 V+D ++n r +++
  EFC39450.1 111 VCDtNCNAREKQY 123
                 9********9886 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.23
                 EEEEEETTTEEEE CS
         NHL   5 hGvavdsnGdiyV 17 
                 +G++ +s G+iy+
  EFC39450.1 188 SGTCTNSLGEIYI 200
                 79**********8 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.45
                 EEEECCCTEE CS
         NHL  16 yVaDsenhrv 25 
                 +V+D++n+r+
  EFC39450.1 490 IVSDRGNNRL 499
                 79*******8 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.46
                 SSEEEEEEETTT CS
         NHL   2 nyPhGvavdsnG 13 
                 n P+G++++s+ 
  EFC39450.1 520 NGPTGICYLSDR 531
                 68******9764 PP

  == domain 5  score: 14.9 bits;  conditional E-value: 1.5e-05
                 BSSEEEEEEETTTEEEEEECCCTEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrv 25 
                 fn+P G++  + + i+VaDs+nh +
  EFC39450.1 576 FNQPVGLSC-TLDKILVADSHNHAI 599
                 99*******.7************98 PP

  == domain 6  score: 24.0 bits;  conditional E-value: 2e-08
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 fn+P Gv+  +  +i+VaD++nhrv+v
  EFC39450.1 632 FNNPMGVCF-QERNIIVADTNNHRVRV 657
                 89*******.***************98 PP

  == domain 7  score: 1.0 bits;  conditional E-value: 0.38
                 BSSEEEEEEETTTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVa 18 
                 +n+Ph+v +  ++ +y+a
  EFC39450.1 688 LNSPHDVQY-EDNVVYIA 704
                 799******.9*****98 PP

  == domain 8  score: 8.7 bits;  conditional E-value: 0.0014
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P+G+++ s+  i+++Ds+n+r++
  EFC39450.1 724 LNFPTGLSL-STKYIVISDSKNNRLR 748
                 79*******.8*************86 PP

  == domain 9  score: 10.3 bits;  conditional E-value: 0.00041
                 EEEEETTTEEEEEECCCTEE CS
         NHL   6 GvavdsnGdiyVaDsenhrv 25 
                 Gv++++n++iyV+D  n+ +
  EFC39450.1 779 GVTISPNNEIYVSDVLNNLI 798
                 9*************777666 PP

  == domain 10  score: 9.3 bits;  conditional E-value: 0.00089
                 SSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   2 nyPhGvavd.snGdiyVaDsenhrvqv 27 
                 ++P+ ++v+  ++di+ +D++nhr+++
  EFC39450.1 830 ASPSNIVVNpLTNDIIFSDTNNHRIRI 856
                 678889999889*************97 PP

  == domain 11  score: 11.7 bits;  conditional E-value: 0.00015
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 P+G+++++ Gd+y aDs+n r+ +
  EFC39450.1 936 PEGLSISNEGDVYFADSKNLRISK 959
                 9********************976 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   1.1       1.1   1.6e+03      10      18 ..     108     116 ..     107     128 .. 0.79
   2 !   17.7  10.0   2.5e-06    0.0034       7      32 .]     991    1015 ..     988    1015 .. 0.91
   3 !   17.4   7.9   3.1e-06    0.0043       6      32 .]    1029    1054 ..    1024    1054 .. 0.92
   4 !   11.6  13.4   0.00021      0.28       7      32 .]    1067    1091 ..    1059    1091 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 1.1
       EGF_2  10 ghGtCvnqc 18 
                 g+G+C++ c
  EFC39450.1 108 GNGVCDTNC 116
                 7999*9555 PP

  == domain 2  score: 17.7 bits;  conditional E-value: 2.5e-06
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+ hG+C++ + +C+C +gy+G++C
  EFC39450.1  991 SCSSHGSCIDRN-NCQCMNGYTGNSC 1015
                  5*******9888.8************ PP

  == domain 3  score: 17.4 bits;  conditional E-value: 3.1e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+  GtCv+++ +C+C sgy G++C
  EFC39450.1 1029 SVCSYSGTCVSPN-KCECVSGYAGDQC 1054
                  68********999.************* PP

  == domain 4  score: 11.6 bits;  conditional E-value: 0.00021
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+++G+C + +  C C++gy G tC
  EFC39450.1 1067 GCNNRGKCHARN-FCICENGYAGTTC 1091
                  4*******8666.9************ PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.2   4.6e-07   0.00063     109     260 ..    1184    1330 ..    1125    1366 .. 0.59

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 4.6e-07
  Haspin_kinase  109 seklssevyqtkekdkevvlKvipl....evledvtiskelslkelkslklvkgtypglllllqdkvlkekpdfyseqqlflvlllkdkGtdLe 198 
                     +e+ ++ v+ tk +  ++++Kv  l       +d++i+  + l +l+  ++++    g+     ++ +  +  ++ ++ l  ++   +kGt+  
     EFC39450.1 1184 GEGGMGSVFMTKYNGMKIAVKVFDLnnfnISEDDFKIE-AILLSKLRHPNIINFY--GISSTPTKRFIAME--CM-DKSLESMISSLQKGTSTC 1271
                     66666666666666666666666663332222334443.4445555555555533..44443333333333..23.333333333334455443 PP

  Haspin_kinase  199 evklkswkqalsifwqivkiLyvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRlesse 260 
                      +k+k  + +l++    ++ L+  E +f   HRdL+  niL+dkn+   l+d+ l+R+ ss+
     EFC39450.1 1272 SLKMK-LSIILNVVS-GINYLHHLEPNFII-HRDLKPANILLDKNGIAKLCDFGLGRALSSN 1330
                     33332.344444432.34678999999965.***************************8443 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.6   3.3   9.5e-05      0.13       4      31 ..     988    1013 ..     985    1014 .. 0.91
   2 !   11.6   2.7   0.00019      0.26       6      31 ..    1031    1052 ..    1024    1053 .. 0.89
   3 ?    5.6   9.6     0.014        20       6      31 ..    1068    1089 ..    1059    1090 .. 0.83

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 9.5e-05
                  TT..STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 np..CsngGtCvdtgrggytCiCpeGytGk 31  
                  +p  Cs +G C+d      +C+C +GytG+
  EFC39450.1  988 DPssCSSHGSCIDRN----NCQCMNGYTGN 1013
                  6888*******9999....**********7 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00019
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs  GtCv++     +C+C +Gy+G+
  EFC39450.1 1031 CSYSGTCVSPN----KCECVSGYAGD 1052
                  ***********....**********7 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.014
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  C+n+G+C         CiC +Gy+G 
  EFC39450.1 1068 CNNRGKCHARN----FCICENGYAGT 1089
                  *******7777....9********95 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0     0.001       1.4     115     165 ..     497     551 ..     483     561 .. 0.80
   2 ?    0.2   0.0      0.34   4.7e+02     136     165 ..     633     662 ..     588     685 .. 0.66
   3 ?   -0.2   0.0      0.45   6.2e+02     138     211 ..     779     802 ..     725     866 .. 0.62
   4 ?    1.3   0.0      0.16   2.2e+02     151     209 ..     904     959 ..     894     981 .. 0.62

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.001
         SGL 115 galyrldpdgk....lervlddltipNGlawspdgktlYlaDsltrkiwaydvda 165
                   l+ +d dg+    +  ++d+++ p G++  +d + +++ D+ ++ +  y++ +
  EFC39450.1 497 NRLLLIDFDGRnittIASMKDGINGPTGICYLSDRSMVIFSDTGNHVLRYYNIRT 551
                 5566666663334449999***************************999998865 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.34
         SGL 136 pNGlawspdgktlYlaDsltrkiwaydvda 165
                  N +++  +++ +++aD+ ++++ ++dv+ 
  EFC39450.1 633 NNPMGVCFQERNIIVADTNNHRVRVIDVNN 662
                 444444444555555555555555555543 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.45
         SGL 138 GlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfd 211
                 G+ +sp +  +Y+ D l++ i +                                                 ++
  EFC39450.1 779 GVTISPNN-EIYVSDVLNNLIRR-------------------------------------------------IK 802
                 33333322.23333333333333.................................................32 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.16
         SGL 151 aDsltrkiwaydvdaeggklsnrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvr 209
                  Ds++++i +++    ++ +    ++a  ++  g+p Gl + +eG v+ A  ++ ++++
  EFC39450.1 904 SDSANGRIRKISK--VNN-IYMVSTIAGPPDLIGVPEGLSISNEGDVYFADSKNLRISK 959
                 5555555555443..233.4455555444444466666666666666666655555544 PP

>> Seadorna_VP7  Seadornavirus VP7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.1   7.8e-06     0.011     143     188 ..    1279    1322 ..    1270    1343 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 7.8e-06
  Seadorna_VP7  143 tvniivaglkdLmdfhsestnllhGDcnpenlmcDknGylklvDPv 188 
                     +  +v g++ L+  h e ++++h D +p n++ DknG  kl D +
    EFC39450.1 1279 IILNVVSGINYLH--HLEPNFIIHRDLKPANILLDKNGIAKLCDFG 1322
                    4445666777664..667999**********************965 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.2    0.0001      0.14      61      95 ..    1101    1134 ..    1083    1184 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.0001
     TMEM154   61 miiiPlvllillllvviiliqkkkrkrsKddekse 95  
                  ++++ +v+li++ +vv+ili ++ +  +K+++  +
  EFC39450.1 1101 LVAVFAVALIIIGIVVLILIFVFSK-YRKQKKIID 1134
                  48999***************66655.456664444 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00012      0.16     114     215 ..    1247    1352 ..    1242    1378 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00012
  Kinase-like  114 llllpaasvdleilnkvlqkrsethkkletiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvlseve..... 204 
                   ++ +  +   le + + lqk  +t     +++  l  +  i+   +L  + ++h ++++ n+lld++g  +l +f+ L ra  +  +s +      
   EFC39450.1 1247 FIAMECMDKSLESMISSLQKGTSTCSLKMKLSIILNVVSGINYLHHLEPNFIIHRDLKPANILLDKNGIAKLCDFG-LGRALSSNTVSAITskvgt 1341
                   555666677777777777777777444444444444466678888888889************************7.4444444444444434435 PP

  Kinase-like  205 kgfaPpEllgs 215 
                     +  pEl++ 
   EFC39450.1 1342 YNYMSPELFSD 1352
                   56667777765 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   0.00026      0.35     163     193 ..    1293    1321 ..    1282    1325 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00026
                  SS-EEEE-SS-SGGGEEEC..TTEEEEE--- CS
         APH  163 elptvllHgDlhpgNllvdpddgrvtGviDf 193 
                   +p  ++H+Dl+p N+l+d  ++ +  + Df
  EFC39450.1 1293 LEPNFIIHRDLKPANILLD--KNGIAKLCDF 1321
                  567889*************..7766555555 PP

>> SLIDE  SLIDE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.5   0.00034      0.47      16      62 ..    1125    1170 ..    1122    1183 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00034
       SLIDE   16 klkelkellkkkveqyknplqelkikyppsnkgkkeyteeeDrfllv 62  
                  k +++k++++  +   ++ l++ +++ ++++++++ y +eeD+f++ 
  EFC39450.1 1125 KYRKQKKIIDTDLTLDERLLSQTELEISNTSSNRT-YHQEEDKFIIP 1170
                  7889999999999999999*******977777766.*********85 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   8.2     0.009        12       3      28 ..     989    1015 ..     988    1016 .. 0.89
   2 ?    4.1   9.0     0.036        50       6      28 ..    1031    1054 ..    1030    1055 .. 0.91
   3 ?    9.6   1.3   0.00067      0.92       5      28 ..    1067    1091 ..    1066    1092 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.009
  EGF_Tenascin    3 PLGCssRGvCvD.GqCiCDsEYsGDDC 28  
                    P  Css G C+D   C C   Y G+ C
    EFC39450.1  989 PSSCSSHGSCIDrNNCQCMNGYTGNSC 1015
                    667*********447**********99 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.036
  EGF_Tenascin    6 CssRGvCvD.GqCiCDsEYsGDDC 28  
                    Cs  G Cv   +C C s Y+GD C
    EFC39450.1 1031 CSYSGTCVSpNKCECVSGYAGDQC 1054
                    9*******8368************ PP

  == domain 3  score: 9.6 bits;  conditional E-value: 0.00067
  EGF_Tenascin    5 GCssRGvCvD.GqCiCDsEYsGDDC 28  
                    GC  RG C     CiC+  Y+G  C
    EFC39450.1 1067 GCNNRGKCHArNFCICENGYAGTTC 1091
                    9*******76267*********999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       958  (0.053433); expected 358.6 (0.02)
Passed bias filter:                      577  (0.0321825); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 1.05u 0.35s 00:00:01.40 Elapsed: 00:00:00.51
# Mc/sec: 8677.79
//
Query:       EFC39451.1  [L=522]
Description: cation diffusion facilitator [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.8e-20   71.5  12.0    3.5e-19   69.3  12.0    1.8  1  Cation_efflux  Cation efflux family
      2e-12   47.0   0.1    5.9e-12   45.5   0.1    1.7  2  ZT_dimer       Dimerisation domain of Zinc Transporter
  ------ inclusion threshold ------
      0.072   13.5   1.1        7.8    7.0   0.8    2.6  2  GP67           Gene product 67
        1.2    9.5   7.9        9.5    6.6   0.3    2.9  2  Orf78          Orf78 (ac78)


Domain annotation for each model (and alignments):
>> Cation_efflux  Cation efflux family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.3  12.0   7.8e-23   3.5e-19       3     198 ..     199     425 ..     197     426 .. 0.96

  Alignments for each domain:
  == domain 1  score: 69.3 bits;  conditional E-value: 7.8e-23
  Cation_efflux   3 lsllanlilalvelivglltnSlalladafhslsdlvsllllllalkls.rkppderfpfGygrlevlgalvsgllllglavfllleaiqkli... 94 
                    +s+++n++l++ ++ + +l+ Sl+++   + s++d+vs l+l+ + +l  +k  ++++p G  rle+l  ++ +  +  + ++++ e++  +i   
     EFC39451.1 199 ASFWVNILLLFLKVSASFLSISLSVITSTVDSILDIVSGLILVYTNHLRkKKGDSHKYPVGKDRLEPLSFIIFATCMATASLQIIKEGVVTIIqgl 294
                    799**********************************************999999***************************************** PP

  Cation_efflux  95 ....................................kegereihaglalvvalvslvvnlalllilrragrklrsaalkaaalhvlgDaltslgvl 154
                                                            ++   ++ l+v+lv++v++ +l+++++ra    +sa+ +a a+++++D+l++   +
     EFC39451.1 295 vtgdpylpannenliswssqpetlsgemewmlgikvPATFKLFAYSYSLAVMLVAVVLKTILYFLCIRA----KSASCEAYAFDHRNDVLSNSFLV 386
                    **********************************997788999**************************....*****************999888 PP

  Cation_efflux 155 vsalvillfnlksgplaDpvaslligliilysalkllkeslseL 198
                     s++++++    +  ++Dp+ + +++++i+y +++  +e +  L
     EFC39451.1 387 ASLFISMWA---W--WVDPFSATVLSCYIIYGWVGESMEHVTKL 425
                    888887776...4..9**********************999887 PP

>> ZT_dimer  Dimerisation domain of Zinc Transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0         2     9e+03      15      36 ..     143     164 ..     131     165 .. 0.65
   2 !   45.5   0.1   1.3e-15   5.9e-12       4      77 ..     433     506 ..     430     506 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 2
                 T-SS-EEEEEEEEE-S----EE CS
    ZT_dimer  15 svpgvkgvhdlrtrksGskifv 36 
                 + + v+g+ dl t ++ ++ +v
  EFC39451.1 143 QNELVEGFADLYTNTITKDFLV 164
                 3556999999999887666665 PP

  == domain 2  score: 45.5 bits;  conditional E-value: 1.3e-15
                 .HHHHHHHHH.TT-SS-EEEEEEEEE-S----EEEEEEEE-TTS-HHHHHHHHHHHHHHHHHH-TT--EEEEEEE CS
    ZT_dimer   4 eeeeeireii.ksvpgvkgvhdlrtrksGskifvdlhievdgdlsvkeaHeiadevekrikeefpgvadvliHve 77 
                 + +++++ i+ ++++++++v+ + + +sG +i++++h+++++d+s+keaH+i  +++ +i+ ++p+v+++++H++
  EFC39451.1 433 DLIQKLTFIAyNHCEKIVKVDLVTAWYSGMNIIAEIHVVLPPDMSLKEAHNIGAKLQTKIE-SVPEVERCFVHLD 506
                 567788888877899*********************************************5.89*********86 PP

>> GP67  Gene product 67
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.8    0.0017       7.8      38      68 ..     157     191 ..     152     195 .. 0.76
   2 ?    3.7   0.0     0.018        81      19      42 ..     270     293 ..     267     303 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0017
        GP67  38 aiarnfliege....epededededdedsddkddk 68 
                 +i+++fl++ge    e +de ++e+  ds  kdd+
  EFC39451.1 157 TITKDFLVDGEdgylELNDELKEENPIDSSAKDDR 191
                 5899*******333334677777788899999997 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.018
        GP67  19 lfaeamaartidlikeekiaiarn 42 
                 +fa +ma+ ++++ike  ++i + 
  EFC39451.1 270 IFATCMATASLQIIKEGVVTIIQG 293
                 79**************99999765 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   2.5    0.0082        37      27      67 ..      23      59 ..       9      62 .. 0.52
   2 ?    6.6   0.3    0.0021       9.5      70      95 ..     342     367 ..     321     374 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0082
       Orf78 27 dnddndkaenkkekksaaeknditekesnaaekaqalnill 67
                d+++n++ e++++  ++ ++n+ ++++++  +++q + +++
  EFC39451.1 23 DSNNNNNGEQQHDV-EVVARNEEQSTQHQ--QQQQ-QFNVM 59
                34455554444444.44444444444444..2333.33333 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0021
       Orf78  70 llavvcvlvllyviyYfvilrerqks 95 
                  lav+ v v+l  i+Yf+ +r ++ s
  EFC39451.1 342 SLAVMLVAVVLKTILYFLCIRAKSAS 367
                 58999***************998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1976  (0.110213); expected 358.6 (0.02)
Passed bias filter:                      728  (0.0406046); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 3076.46
//
Query:       EFC39452.1  [L=556]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.1e-13   50.9   0.1    1.8e-13   50.1   0.1    1.4  1  UDPGT            UDP-glucoronosyl and UDP-glucosyl transferas
      8e-05   22.7   0.0     0.0002   21.4   0.0    1.7  2  Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal dom
  ------ inclusion threshold ------
      0.054   13.3   0.0       0.11   12.4   0.0    1.4  1  Phage_T4_gp19    T4-like virus tail tube protein gp19


Domain annotation for each model (and alignments):
>> UDPGT  UDP-glucoronosyl and UDP-glucosyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.1   0.1     3e-17   1.8e-13     325     490 ..     380     550 ..     335     556 .] 0.74

  Alignments for each domain:
  == domain 1  score: 50.1 bits;  conditional E-value: 3e-17
       UDPGT 325 llvkWlPqndlLgHPktkAFvtHaGangvyEaisnGvPmvglPlFgdqrdNikrmeak...gaavtlnvkem..tsedllnAlkevindksykenimrL 418
                 ll  ++Pq +l+   k+k F tH Gan+v Ea++ G  ++g P+  dq + ++ +e      a  +  ++ m   se + +A++e++ ++  k+ + + 
  EFC39452.1 380 LLKGFVPQKALMSIEKVKIFFTHCGANSVNEALYFGKLLIGFPYAFDQWKVAHTIEEFqlgRAIYKSREESMvwKSESISQAIHELLYNE-EKRELYKT 477
                 67779*******************************************99888887641114556667777744599**********887.45555555 PP

       UDPGT 419 sslhkDrPvk...PLDravfWiefvmrhkGAkhlRaaahdLtWyqyhsLDvi...gfllavvvtvafiivkeclfvyr 490
                    h    ++    + ra   +e v   +G    + a + LtW+qy+ LD++   +fl+  vv        ++l + r
  EFC39452.1 478 KARHTKSLMRrsgGVKRAAEIVEMVSEVDGDLSWKIADKHLTWWQYYCLDIVlvySFLMYLVVKL-----ACLLCCNR 550
                 5556555444222689**********************************873224555555444.....44444444 PP

>> Glyco_tran_28_C  Glycosyltransferase family 28 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0         2   1.2e+04     122     147 ..     103     128 ..      98     138 .. 0.66
   2 !   21.4   0.0   3.3e-08    0.0002      70     154 ..     393     478 ..     372     500 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 2
                      HSSEEEE-STTCHHHHHHHHCCS--- CS
  Glyco_tran_28_C 122 lvleqkeltpekLeeallelaaeklr 147
                      +vl  k++++  Lee l++la+ +++
       EFC39452.1 103 EVLNGKVINIVPLEERLQKLAKTPQK 128
                      55555666666677777777776665 PP

  == domain 2  score: 21.4 bits;  conditional E-value: 3.3e-08
                      HHHH-EEEECS-CHHHHHHHHTT--EEEE--TT....S-HHHHHHHHH.HHHHHSSEEEE-S....TTCHHHHHHHHCCS---..S---SSC CS
  Glyco_tran_28_C  70 ikaadLvIsRAGagtiaEllalgkplIlvplpeaaenhqdnNakelek.agaalvleqkelt....pekLeeallelaaeklr..laekska 154
                      i++ ++  ++ Ga++++E+l++gk lI +p+      +q + a  +e+ +++  +++ +e +     e++ +a+ el+ ++++  l   +++
       EFC39452.1 393 IEKVKIFFTHCGANSVNEALYFGKLLIGFPYAF----DQWKVAHTIEEfQLGRAIYKSREESmvwkSESISQAIHELLYNEEKreL--YKTK 478
                      67788999*************************....**********966666667766666778899********9998888432..2222 PP

>> Phage_T4_gp19  T4-like virus tail tube protein gp19
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   1.8e-05      0.11      44      89 ..       7      49 ..       2      58 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 1.8e-05
                   EEEEEEE--EEEEEE--HHHHHHHHHHHHT--SSB---EEEEEEEE CS
  Phage_T4_gp19 44 lpgrtkyenltLkrgltsdselvkWfkkvieggvkearknisisll 89
                   +p+  + + +t+k g+++d++l kW+++v+  + +   +++ + ++
     EFC39452.1  7 SPTVSNITLMTVKIGMMADPRLKKWYSQVNGTDAD---RKVHVAVM 49
                   6777788889*******************988776...55666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (556 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       546  (0.0304535); expected 358.6 (0.02)
Passed bias filter:                      371  (0.0206927); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.28s 00:00:00.83 Elapsed: 00:00:00.44
# Mc/sec: 3807.82
//
Query:       EFC39453.1  [L=1508]
Description: serine/threonine protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.1e-48  164.5   0.0    6.9e-48  163.3   0.0    1.5  1  Pkinase         Protein kinase domain
    4.3e-45  154.0   0.2    3.2e-43  147.9   0.2    2.2  1  Pkinase_Tyr     Protein tyrosine kinase
    6.4e-19   67.0   0.0     0.0015   18.5   0.0    7.9  7  NHL             NHL repeat
    8.9e-09   35.6  60.3    0.00068   20.0  11.3    4.9  4  EGF_2           EGF-like domain
     0.0018   17.9   0.4      0.069   12.7   0.0    3.7  4  SGL             SMP-30/Gluconolactonase/LRE-like region
     0.0044   17.0   0.0     0.0087   16.0   0.0    1.4  1  APH             Phosphotransferase enzyme family
       0.01   14.8   2.0      0.028   13.4   0.1    2.5  2  Haspin_kinase   Haspin like kinase domain
  ------ inclusion threshold ------
      0.022   13.6   0.0      0.033   12.9   0.0    1.2  1  Pkinase_fungal  Fungal protein kinase
      0.047   14.1   0.1       0.13   12.7   0.1    1.8  1  SIT             SHP2-interacting transmembrane adaptor protei
      0.074   13.3   0.4        7.2    6.9   0.0    3.9  4  Arylesterase    Arylesterase
      0.094   12.0   0.0       0.27   10.5   0.0    1.8  1  GSDH            Glucose / Sorbosone dehydrogenase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  163.3   0.0   4.2e-51   6.9e-48       4     261 ..    1208    1502 ..    1206    1503 .. 0.83

  Alignments for each domain:
  == domain 1  score: 163.3 bits;  conditional E-value: 4.2e-51
                  EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS-- CS
     Pkinase    4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsls 96  
                  +++lGeG++G+V+  +   +g +vAvK+++ ++ + ++ +++ +E  +l kl+hpni+++y++ ++++++y+++e+++ ++l++++     ++ s++
  EFC39453.1 1208 IKRLGEGGMGSVFMTK--FNGMTVAVKVFDLNNLNISE-EDFKNEAIVLSKLRHPNIINFYGISTSPTKRYIIMECLD-QSLEKVIAklemKQLSFT 1300
                  689**********999..8************9988766.59*************************************.569999988888888899 PP

                  HHHHHHHHHHHHHHHHHHH...HTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH....TTSCBSHHHHHHHHH CS
     Pkinase   97 eeeakkiakqilegleylH...skgiiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl....keneyskkvDvWslG 184 
                   e+  +++ +i++g+eylH    ++iiHrDlK++NiL+d++g+ K++DFGl+k +++ +   lt++ gt+ Y+APE+      +  y ++vD++s  
  EFC39453.1 1301 LEQKLRMLLNIANGIEYLHflkPRRIIHRDLKTANILLDSNGNCKVCDFGLSKSISQATVsaLTNQLGTHFYMAPELFdikpIDPTYATSVDIYSFS 1397
                  99999**************554455*******************************998789***************9876666889********** PP

                  HHHHHHHHS.S-STTTSSHHHHHHHHHHTHHHHHHHCT........SHH...HHHTTS............................-HHHHHHHHHH CS
     Pkinase  185 vilyelltg.kppfsgekgkekvekeldqlekilkilg........etkeklpeasei............................seeakdllkkl 244 
                  +i+++ll++ k p+ +++ +      l++   ++ il+        ++  + ++                                   + +l++++
  EFC39453.1 1398 IIMWQLLFEiKDPYLSKSPEI-----LRK-LGTTSILEqvtsyqltKMICENNH---RpsipfnsieschewcfeympssqdespqIFALSQLIQEC 1485
                  ******986356666333333.....333.222223321112322222223333...1455888899**************99665556899***** PP

                  T-SSGCCSTTHHHHHTS CS
     Pkinase  245 lkkdpkkRltaeellqh 261 
                  ++ dpk R+ +e+++qh
  EFC39453.1 1486 WQTDPKLRPNIEQVIQH 1502
                  ****************9 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  147.9   0.2   1.9e-46   3.2e-43       5     259 .]    1209    1503 ..    1206    1503 .. 0.84

  Alignments for each domain:
  == domain 1  score: 147.9 bits;  conditional E-value: 1.9e-46
                   EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTE..BHHHHHHHTCTT CS
  Pkinase_Tyr    5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgG..dLlkfLrkkeke 98  
                   k+lGeG  G+V++ + +       ++VavK+++ ++ + ++e++ +ea +++kl+hpni++++g+ t+  + +i++e +++   ++   L+ k + 
   EFC39453.1 1209 KRLGEGGMGSVFMTKFN------GMTVAVKVFDLNNLNISEEDFKNEAIVLSKLRHPNIINFYGISTSPTKRYIIMECLDQSleKVIAKLEMK-QL 1297
                   89*************99......9*********9999999*************************************9987433444455555.88 PP

                   TSBHHHHHHHHHHHHHHHHHHH...HTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE....EEHHHH CS
  Pkinase_Tyr   99 kltlkdllsfalqvAkGmeyLe...skklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk....ftsksD 187 
                   ++tl+++l++ l++A+G+eyL+    ++++Hrdl + N+Ll++n  +k++DfGL+++i ++ + ++ +++     +mapE ++ k     + ++ D
   EFC39453.1 1298 SFTLEQKLRMLLNIANGIEYLHflkPRRIIHRDLKTANILLDSNGNCKVCDFGLSKSI-SQATVSALTNQLGTHFYMAPELFDIKPidptYATSVD 1392
                   899***************9987222578******************************.6777778888888999******997767777****** PP

                   HHHHHHHHHHHHTTSSGT........................................TTTSHHHHHHHHHHTTEES-BBTTSBH..HHHHHHHHH CS
  Pkinase_Tyr  188 vWsfGvllwEiftlgesp........................................ypglkneevleklkegkrlekpekcpe..elyelmkkc 241 
                   ++sf++++w ++   ++p                                        ++++   e ++    ++  +  ++ p+  +l +l+++c
   EFC39453.1 1393 IYSFSIIMWQLLFEIKDPylskspeilrklgttsileqvtsyqltkmicennhrpsipFNSI---ESCHEWCFEYMPSSQDESPQifALSQLIQEC 1485
                   ***********************************999999999988888887554333333...233333333333333333332268899**** PP

                   T-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  242 weedpeeRptfselvekl 259 
                   w++dp+ Rp++++++++l
   EFC39453.1 1486 WQTDPKLRPNIEQVIQHL 1503
                   **************9986 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.0      0.68   1.1e+03       4      21 ..     283     300 ..     282     301 .. 0.90
   2 !    7.4   0.0    0.0029       4.8       5      21 ..     377     396 ..     373     401 .. 0.82
   3 !   18.5   0.0   9.2e-07    0.0015       1      26 [.     521     547 ..     521     547 .. 0.95
   4 !    8.0   0.0    0.0019       3.2      15      27 ..     593     605 ..     585     606 .. 0.89
   5 !    9.8   0.0   0.00051      0.83      14      27 ..     684     697 ..     674     698 .. 0.87
   6 ?    5.3   0.0     0.014        22       1      27 [.     817     844 ..     817     845 .. 0.90
   7 !    6.3   0.0    0.0067        11       1      23 [.     872     894 ..     872     899 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.68
                 EEEEEEETTTEEEEEECC CS
         NHL   4 PhGvavdsnGdiyVaDse 21 
                 P G++ ++++ i+  D e
  EFC39453.1 283 PKGLSFLPDDSILTLDHE 300
                 99************9965 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0029
                 EEEEEE.TTTEEEEEE..CC CS
         NHL   5 hGvavd.snGdiyVaD..se 21 
                 + +a + s+G+++VaD  se
  EFC39453.1 377 SAIAFNeSSGELFVADssSE 396
                 5699************6555 PP

  == domain 3  score: 18.5 bits;  conditional E-value: 9.2e-07
                 BSSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvq 26 
                 + +Ph+v +  s+  +y+aDs+nhrv+
  EFC39453.1 521 LDRPHSVYYEgSTRTLYIADSGNHRVR 547
                 679**********************96 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0019
                 EEEEECCCTEEEE CS
         NHL  15 iyVaDsenhrvqv 27 
                 ++++Ds+nhrv++
  EFC39453.1 593 LFISDSNNHRVRW 605
                 799********86 PP

  == domain 5  score: 9.8 bits;  conditional E-value: 0.00051
                 EEEEEECCCTEEEE CS
         NHL  14 diyVaDsenhrvqv 27 
                 +iy+aDs+n+r+++
  EFC39453.1 684 EIYIADSYNNRIRK 697
                 7***********97 PP

  == domain 6  score: 5.3 bits;  conditional E-value: 0.014
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +++P+G++ + +   +y aDs n+r+++
  EFC39453.1 817 LASPTGLSFSpNHSTVYFADSSNNRIRK 844
                 578999999999999***********97 PP

  == domain 7  score: 6.3 bits;  conditional E-value: 0.0067
                 BSSEEEEEEETTTEEEEEECCCT CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenh 23 
                 fn+P+ +a ++nGd+++ D+ ++
  EFC39453.1 872 FNNPRLIATLTNGDVVIGDTLSN 894
                 899999*************7555 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   6.4   4.2e-05     0.068       7      32 .]     967     992 ..     962     992 .. 0.86
   2 !   16.0   7.3   7.2e-06     0.012       6      32 .]    1006    1032 ..    1001    1032 .. 0.84
   3 ?    3.9  11.3     0.042        69       1      32 []    1037    1071 ..    1037    1071 .. 0.91
   4 !   20.0  11.3   4.2e-07   0.00068       5      32 .]    1084    1110 ..    1076    1110 .. 0.88

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 4.2e-05
       EGF_2   7 iCgghGtCvnqcGqCdC.dsgyqGktC 32 
                  C+ +G C ++  +C+C +  y+Gk C
  EFC39453.1 967 VCSSRGECTSPD-NCKCwNGLYTGKEC 992
                 7********999.8***666677**** PP

  == domain 2  score: 16.0 bits;  conditional E-value: 7.2e-06
       EGF_2    6 eiCgg.hGtC.vnqcGqCdCdsgyqGktC 32  
                  + C+  +GtC +  +++C+C +g++G tC
  EFC39453.1 1006 NVCSYgNGTCmI--NNKCQCLDGFYGETC 1032
                  457655****88..889************ PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.042
       EGF_2    1 Csas..deiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  C +   +e Cgg  +G C n+  +C+C + y+G +C
  EFC39453.1 1037 CFSKiiGESCGGpsRGACTNKD-VCKCGQFYTGEQC 1071
                  777778899*********9888.9***********9 PP

  == domain 4  score: 20.0 bits;  conditional E-value: 4.2e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ghG+C  ++G+C+Cd+ y G++C
  EFC39453.1 1084 KSVCSGHGKCQ-ANGRCECDTLYIGDDC 1110
                  678*******7.699************* PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.8     3e+03      46      82 ..     121     158 ..      99     169 .. 0.60
   2 ?   -2.7   0.0       2.2   3.6e+03     113     138 ..     384     407 ..     364     411 .. 0.68
   3 ?   -0.2   0.0      0.37     6e+02     144     165 ..     532     553 ..     515     559 .. 0.82
   4 !   12.7   0.0   4.2e-05     0.069     133     161 ..     817     845 ..     802     931 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.8
         SGL  46 iaprkd.grlvvasksglalldlasgeletladeeede 82 
                  ++  d +++++ s ++++l++ ++g ++ l d+  d+
  EFC39453.1 121 HVDESDeNQIYLSSFYQIYLFNKREGIITLLSDKDFDK 158
                 34433346777777777777777777777777774344 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.2
         SGL 113 evgalyrldpdgklervlddltipNG 138
                 + g+l++ d +   e +l++++i+NG
  EFC39453.1 384 SSGELFVADSS--SENTLEKINISNG 407
                 33666666655..6777777778877 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.37
         SGL 144 dgktlYlaDsltrkiwaydvda 165
                  ++tlY+aDs ++++ ++++d+
  EFC39453.1 532 STRTLYIADSGNHRVRSVQMDT 553
                 5789999999999999999874 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 4.2e-05
         SGL 133 ltipNGlawspdgktlYlaDsltrkiway 161
                 l+ p Gl +sp ++t+Y+aDs +++i + 
  EFC39453.1 817 LASPTGLSFSPNHSTVYFADSSNNRIRKL 845
                 56799********************9875 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   5.3e-06    0.0087     162     196 ..    1307    1352 ..    1269    1355 .. 0.68

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5.3e-06
                  S.............SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH  162 g.............elptvllHgDlhpgNllvdpddgrvtGviDfeda 196 
                                  p++++H+Dl++ N+l+d++++    v Df+++
  EFC39453.1 1307 MllniangieylhfLKPRRIIHRDLKTANILLDSNGNCK--VCDFGLS 1352
                  13334555777777999****************777666..8999876 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.2       3.1   5.1e+03      10      35 ..     439     464 ..     430     479 .. 0.68
   2 !   13.4   0.1   1.7e-05     0.028     230     257 ..    1328    1355 ..    1146    1370 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 3.1
  Haspin_kinase  10 lksrssqsslkhktshssLqkfssss 35 
                    l+ + s+  l +  s+ss+qkf+  +
     EFC39453.1 439 LQIKDSNLFLANTGSQSSIQKFDLAQ 464
                    444556666788899******95443 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 1.7e-05
  Haspin_kinase  230 HRdLhldniLvdknlnvtlidlklsRle 257 
                     HRdL+  niL+d+n+n  ++d+ ls+  
     EFC39453.1 1328 HRDLKTANILLDSNGNCKVCDFGLSKSI 1355
                     ***********************99864 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   2.1e-05     0.033     303     387 ..    1302    1379 ..    1289    1403 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 2.1e-05
  Pkinase_fungal  303 espkellealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlk 387 
                      e+++++l  +++ I+ +  L    +i+HrD  + Nil+      ++ +  + D+ l k++s+  + s+  ++ GT  +ma e+  
      EFC39453.1 1302 EQKLRMLLNIANGIEYLHFLK-PRRIIHRDLKTANILLD-----SNGNCKVCDFGLSKSISQ-ATVSALTNQLGTHFYMAPELFD 1379
                      566777888888898888888.99**************9.....44556689*********7.6666679**********88865 PP

>> SIT  SHP2-interacting transmembrane adaptor protein, SIT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1     8e-05      0.13       2      63 ..    1125    1185 ..    1124    1194 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 8e-05
         SIT    2 llllilallLlllviasllawrmkkrqkkaaeysseqisredeevlqPieddicYanLnlqq 63  
                  l+++il+  L++++i+ ++++r+ +r+kk  e++     ++  ++++  e  ++ + L  + 
  EFC39453.1 1125 LIIVILTTMLVVSLILGVIVYRKNRREKKIIETELSL-DERLLSSTDIYEMSLSHGSLASHA 1185
                  789999***********************98873322.333333444445556666666655 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.0      0.86   1.4e+03      54      71 ..     493     510 ..     489     519 .. 0.91
   2 ?    0.2   0.0      0.53   8.6e+02      51      78 ..     519     546 ..     507     552 .. 0.83
   3 ?    6.9   0.0    0.0044       7.2      43      78 ..     807     842 ..     795     846 .. 0.84
   4 ?   -3.6   0.0       8.2   1.3e+04      58      69 ..    1266    1277 ..    1259    1284 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.86
  Arylesterase  54 ssanGInidadkkyiyva 71 
                   + +nGI  +++   iy+a
    EFC39453.1 493 NNPNGIHCSQVYDEIYIA 510
                   679*************98 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.53
  Arylesterase  51 sglssanGInidadkkyiyvadilresi 78 
                   ++l+ +  + ++   + +y+ad+ ++ +
    EFC39453.1 519 AQLDRPHSVYYEGSTRTLYIADSGNHRV 546
                   5678888999999*********988876 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0044
  Arylesterase  43 psevkvvasglssanGInidadkkyiyvadilresi 78 
                   ++  +  ++ l s++G+ +++++  +y ad+ ++ i
    EFC39453.1 807 GDTSEANVAILASPTGLSFSPNHSTVYFADSSNNRI 842
                   555566677899*******************99988 PP

  == domain 4  score: -3.6 bits;  conditional E-value: 8.2
  Arylesterase   58 GInidadkkyiy 69  
                    GI  ++ k+yi 
    EFC39453.1 1266 GISTSPTKRYII 1277
                    9********994 PP

>> GSDH  Glucose / Sorbosone dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00016      0.27       3      55 ..     763     815 ..     761     863 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00016
                 -EEEEEE-TTS-EEEEET.TTEEEEEE.TTEE.EEEEE-.----STT-SEEEEE CS
        GSDH   3 hPwslaflpdgrlLvter.sGrlrlvkadgklkepiagvpevvakgqgGlldva 55 
                 +P ++ f pd+r+L++e  + r+rlv+++g++ ++iag+ +  + g++   +va
  EFC39453.1 763 NPTKILFYPDNRMLISESsTNRIRLVNENGTI-STIAGTGKFGYGGDTSEANVA 815
                 6999*************96789*********9.999999887776666555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       802  (0.044732); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.90u 0.28s 00:00:01.18 Elapsed: 00:00:00.44
# Mc/sec: 10348.18
//
Query:       EFC39454.1  [L=485]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.5e-63  213.4   2.3    1.4e-50  172.4   0.5    2.1  2  PALP      Pyridoxal-phosphate dependent enzyme
    1.1e-06   28.3   0.0    2.8e-06   27.0   0.0    1.7  1  ACT       ACT domain
     0.0079   16.8   0.0       0.02   15.5   0.0    1.6  1  ACT_4     ACT domain
  ------ inclusion threshold ------
      0.076   13.1   0.0       0.24   11.5   0.0    1.8  1  SH3_12    Xrn1 SH3-like domain


Domain annotation for each model (and alignments):
>> PALP  Pyridoxal-phosphate dependent enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.2   0.1   2.8e-14   1.3e-10       7      66 ..     109     177 ..     103     180 .. 0.84
   2 !  172.4   0.5     3e-54   1.4e-50      92     294 .]     180     384 ..     178     384 .. 0.97

  Alignments for each domain:
  == domain 1  score: 41.2 bits;  conditional E-value: 2.8e-14
                 S--EEEECCTC.......CCCCCE..EEEEEGGGSTTSBTTHHHHHHHHHHHHTTTTTSEEEEEBSSHH CS
        PALP   7 pTPlvrlprls.......kelgvp..lflKlEslnptgSfKdRgaeyllarlkegtgaktvveassGNh 66 
                 pTPl ++  l+       k++ +p  +flK+E+ + tgSfK Rga + la+l+ ++++++vv++s+GNh
  EFC39454.1 109 PTPLQESAVLTqeifgqqKNVLHPrkVFLKYENKHMTGSFKERGAINKLAALDTEQRKRGVVASSAGNH 177
                 78887777777655555455555589*****************************9************9 PP

  == domain 2  score: 172.4 bits;  conditional E-value: 3e-54
                 HHHHHHHHTT-EEEEECCHHHHHHHHHHHHHHHSTTCEE--TTTSHHHHHHHHTHHHHHHHHTTTTEEEEEEE-SSSHHHHHHHHHHHHHSTT-EEEEE CS
        PALP  92 ekvallrllGaevvevggdydeavaaaaelaaegegaylvsqfdnptviegygtiglEileqlggkpdavvvpvGgGgliaGiaaglkerrpdvrvigv 190
                 +kva ++++Gaevv++g+++d+a + a ++ +  e+++lv++f++ ++i+g+gt+glE+leq  + +d++v+p+GgGgli+G+a + k  +p+++v+gv
  EFC39454.1 180 SKVAGTKRYGAEVVLFGESVDDAYQEALRIKEA-ENRVLVHPFNDDAIIAGQGTLGLELLEQS-PYIDTIVCPIGGGGLISGVAIACKTVNPKIKVYGV 276
                 799******************************.*************************9999.7********************************** PP

                 EECTTCGGTTCCS..S.SS..B.SSS.CCSTCSCGTTCCHHHHSEEEEEEEEEEHHHHHHHHHHHHHHHSB-B-HHHHHHHHHH...HHHHHHCCTTC. CS
        PALP 191 epegsdalarslragrrvtvpvsdtiadglavgspselafelldrlvdeivtvsdeealeamrllarregivvepssaaalaal...klreagelkeg. 285
                 ++e+++++ ++ ++ + +tvp + tiadg+av++ ++l+f+++d++vd+ivtv++ e++ a+  l +re+ +ve ++a+ +aal   kl+e ++ + g 
  EFC39454.1 277 QTENVPSMVTAKKNRKSTTVPFHATIADGIAVRRIGDLTFPIIDQFVDDIVTVTESEIAHAVLVLLEREKTLVEGAGATPVAALlsgKLEEVTKTSSGs 375
                 **************************************************************************************9888888888877 PP

                 EEEEEEE-B CS
        PALP 286 drvvviltg 294
                  rv++il+g
  EFC39454.1 376 HRVCCILSG 384
                 8******98 PP

>> ACT  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.0   6.3e-10   2.8e-06       2      54 ..     408     460 ..     407     472 .. 0.78

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 6.3e-10
                 EEEEEEESSTTHHHHHHHHHHHTTSEEEEEEEEEESTTECEEEEEEEEEEHHH CS
         ACT   2 vlrvgvpDrPGlLarvfgaladrgiNidsieqrssedkvagivfvvivvdeed 54 
                 +lr+ vpD+PG La+v+++l+++ +Ni+ + + +     +g++ +vi+  +++
  EFC39454.1 408 RLRTVVPDVPGQLAKVLTLLGELKVNIREVDHERNYNVPVGYTGTVITCQTRG 460
                 68999***********************9998876666555555555555555 PP

>> ACT_4  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.0   4.5e-06      0.02       7      69 ..     407     471 ..     402     473 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 4.5e-06
       ACT_4   7 vrleveaedrkglLaditqviseekanivsvnaktrkk..dglaeikitveVkdvehLsrviakL 69 
                 vrl+ ++ d +g La++++++ e k+ni++v  + + +   g++   it + +  eh+++v ++L
  EFC39454.1 407 VRLRTVVPDVPGQLAKVLTLLGELKVNIREVDHERNYNvpVGYTGTVITCQTRGFEHIENVKNSL 471
                 89999*****************************9888888999999999999999999998877 PP

>> SH3_12  Xrn1 SH3-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   5.4e-05      0.24      12      30 ..     437     459 ..     431     476 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5.4e-05
      SH3_12  12 vrdngk.sVPlGlrGtVVg...r 30 
                 v+++ + +VP+G++GtV+    r
  EFC39454.1 437 VDHERNyNVPVGYTGTVITcqtR 459
                 66767788**********86551 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (485 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       556  (0.0310112); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 2842.52
//
Query:       EFC39455.1  [L=824]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-20   73.5   0.2    1.9e-20   73.5   0.2    2.0  2  TLD       TLD
    2.5e-17   63.1   2.3    4.5e-14   52.6   1.3    4.0  2  BTB       BTB/POZ domain
    6.4e-10   39.1   5.2    2.6e-07   30.7   0.3    3.3  3  BACK      BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   2.2         3   1.8e+04      50      86 ..      25      60 ..       8      87 .. 0.57
   2 !   73.5   0.2   3.1e-24   1.9e-20       2     122 ..     670     800 ..     669     824 .] 0.80

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 3
         TLD 50 kkfygdsesflfslspkfkvykstgknkaylntssdg 86
                + + +++++ + +   +  +++s+++n++   t++ g
  EFC39455.1 25 SSITSSASTSISNTTTTSSIITSNNNNNNGSTTTG-G 60
                33444455555555555555555555555444444.4 PP

  == domain 2  score: 73.5 bits;  conditional E-value: 3.1e-24
         TLD   2 lyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl....spkfkvykstgknkaylntssdglgfGggqp.. 94 
                  ++++kdg+  + +++++++kgp +l+++++++yifG+++s +w+ssn+ + + +++flfsl    ++  + +k ++++ a++++ s+g++fGgg +  
  EFC39455.1 670 AFKATKDGFDSNVFHKMCDQKGPSILVCRTTEGYIFGGYNSVEWNSSNQ-WLKANDTFLFSLinpyNDGPRKLKVKNTQRAVYCHASSGPSFGGGTNlv 767
                 799*****************************************98888.************96654445555557777788888888*********** PP

         TLD  95 ..kfsLwidsslekgtsrhs...etfengllsg 122
                    ++L++ds+l++g+++     +tf  g  s+
  EFC39455.1 768 fdPYDLYLDSTLKRGHTNVGgaySTFRGGFRSD 800
                 ******************996665555555443 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.6   1.3   7.6e-18   4.5e-14       6     107 ..     194     351 ..     189     355 .. 0.78
   2 !    4.9   0.0    0.0049        30      81     110 ..     357     386 ..     350     387 .. 0.87

  Alignments for each domain:
  == domain 1  score: 52.6 bits;  conditional E-value: 7.6e-18
                 HHTTTS-EEEEETT...TEEEEE-HHHHHHH-HHHHHHHTST...........................TTTTCCCE......EEEETTSGHHHHHHHH CS
         BTB   6 esgelcDvtlvvgd...gkefkahkavLaarSpyFkalftsk...........................eieessvs......eielddvepeafealL 68 
                 +++el+Dv+l++g    +++f++hk++L+ rS+yF+++f                              +      s       +e ++++p +fe++L
  EFC39455.1 194 DNEELSDVQLRIGSgknQRTFHCHKVILCQRSEYFRNMFLVSrgmflesgtplstgtslpfsgnsevltN------SfgtrisIVEKPNITPIVFEKVL 286
                 7899*********99999***********************99*99999999999999976655544442......15555558999************ PP

                 HHHHHSEEEC-..........................CGGGHHHHHHHHHHHT-HHHHHHHHHHH CS
         BTB  69 efiYtgeleit..........................seenleelLaaadllqiprlkkaceefl 107
                 ++iYtg++++t                            ++ +++Laaad l + +lk+ c +++
  EFC39455.1 287 QYIYTGRVTFTtqlkhkkikdktvhvthmistddidnVISMCMHVLAAADELILLELKNFCVDYV 351
                 ***********999999976666666666666655554455566666666666666666666665 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0049
                 GGGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  81 eenleelLaaadllqiprlkkaceeflkqs 110
                 +e++  lL +a+++  ++l++ c +f+k++
  EFC39455.1 357 SESAIVLLDLASKYGSEDLIENCFDFIKHN 386
                 6778899*******************9986 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.12   6.9e+02       1      28 [.     328     355 ..     328     357 .. 0.93
   2 !   30.7   0.3   4.3e-11   2.6e-07       3      75 ..     362     433 ..     360     441 .. 0.91
   3 !    8.3   0.0   0.00041       2.5      73     103 .]     563     593 ..     550     593 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.12
        BACK   1 clgilefAeaysceeLaeaakefilknf 28 
                 c+++l  A+ + + eL++ + +++++ +
  EFC39455.1 328 CMHVLAAADELILLELKNFCVDYVKQYI 355
                 999********************99976 PP

  == domain 2  score: 30.7 bits;  conditional E-value: 4.3e-11
        BACK   3 gilefAeaysceeLaeaakefilknfeevlkseeFleLskeqllellssdeLnvesEeevfeavlkWvkhdee 75 
                  +l++A++y+ e+L e + +fi++n  ev++se    +sk  ++++l+s+ L   +E e+f+a+l+W   + e
  EFC39455.1 362 VLLDLASKYGSEDLIENCFDFIKHNAREVIASESLPFVSKLTMKTFLESEYL-AVDEIELFRALLRWGLSQIE 433
                 57899***********************************************.778***********766655 PP

  == domain 3  score: 8.3 bits;  conditional E-value: 0.00041
        BACK  73 deeerkkhlpelLekvRlpllspeyLkevve 103
                 d++  +++  +l++++R+pl++  +L++vve
  EFC39455.1 563 DKQLLRDACMDLISCIRFPLMTAHQLTDVVE 593
                 55556677889****************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (824 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1300  (0.0725082); expected 358.6 (0.02)
Passed bias filter:                      586  (0.0326845); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.87u 0.33s 00:00:01.20 Elapsed: 00:00:00.51
# Mc/sec: 4866.51
//
Query:       EFC39456.1  [L=481]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     1e-101  341.0   0.3   1.2e-101  340.8   0.3    1.0  1  FMO-like         Flavin-binding monooxygenase-like
    8.3e-16   58.1   0.4    2.5e-12   46.7   0.0    2.5  3  Pyr_redox_3      Pyridine nucleotide-disulphide oxidoreductas
    2.8e-12   46.4   0.0    2.1e-10   40.3   0.0    2.2  2  K_oxygenase      L-lysine 6-monooxygenase (NADPH-requiring)
    7.1e-10   38.6   0.0    1.8e-07   30.7   0.0    2.2  2  Pyr_redox_2      Pyridine nucleotide-disulphide oxidoreductas
  ------ inclusion threshold ------
      0.033   13.3   0.1      0.066   12.3   0.1    1.5  1  Prenylcys_lyase  Prenylcysteine lyase
       0.16   12.0   0.2        0.8    9.8   0.0    2.0  2  Shikimate_DH     Shikimate / quinate 5-dehydrogenase


Domain annotation for each model (and alignments):
>> FMO-like  Flavin-binding monooxygenase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  340.8   0.3  4.1e-105  1.2e-101      66     528 ..       1     465 [.       1     472 [. 0.89

  Alignments for each domain:
  == domain 1  score: 340.8 bits;  conditional E-value: 4.1e-105
    FMO-like  66 scfsdfplpedypnflhnsklleylklfakefdllkyiqfkttvcsvkkrpdfstsGqwevvtekegkkesavfdavmvctGhhvnphlplesfpGi.e 163
                 + +sdfp+p+++p fl+++k++eylkl+a +f+l +yi+f+t v +++   ++ ++ +++v+ +k ++   + fd +mvctGhh  p++   +f G+ e
  EFC39456.1   1 MSYSDFPIPDEFPTFLPHEKVVEYLKLYAAKFELEQYIEFNTRVENIDLV-NSGSTDKYKVIIRKGDQLSEETFDHIMVCTGHHSTPNIA--TFEGLkE 96 
                 67*********************************************865.677889******************************985..8***945 PP

    FMO-like 164 kfkGqyfhsrdykep...evfkgkrvlviGlGnsggdiavelsrt.aeqvllstrsGswvlsrvsdsGypwdmllvtrfksllknilptalsnwlvekk 258
                 +fkG+++hs+ yk+p   ++f +k vlv+G+Gnsggdia+el+++ a+qv+lstr+Gsw++ r    G p d +   rf+ +l + + +   ++l+   
  EFC39456.1  97 NFKGNVIHSHSYKNPfdsDMFMNKNVLVVGIGNSGGDIAAELAKNvAKQVILSTRRGSWIIPREL-LGDPLDHV--PRFAWMLPRRVIQYANEFLL-TL 191
                 7*************987789**********************986489***************76.79****86..8*****99988877666665.57 PP

    FMO-like 259 lnkrfnhenyglkpkkralakepvlndelparilaGavkvkssvkeltet..saifedgtveedidvvifatGytfafpfleeslvkv...eknkvsly 352
                 +n  +++ +  l p++r    +p++n el ++i  G+v+v +++ ++     ++ fe+     +id v+ +tGy  +fpf+++   +    e+nkvsly
  EFC39456.1 192 VNGDLKKFSKYLAPRHRFFGSHPTVNSELISKINNGVVRVVPNIVRFSRDghTCRFENDENASNIDTVVICTGYRISFPFFKDGFFEDcfdENNKVSLY 290
                 89999888888************************************87522678****************************99875222699***** PP

    FMO-like 353 kkvfpanlekptlaiiGliqplGsilptvelqarwavrvlkGlkklpsekelleeitekkekkakrfgesksktiqtdyiayldelaaligakpnllsl 451
                 k+vf ++   + +a iGliqp G+i+p++elq+r avr+++G  klpse+e+ +++++k+e +a+r++esk++t+q dy +y dela +ig+kp++   
  EFC39456.1 291 KYVFHPKH-GTGIAFIGLIQPFGAIIPISELQSRVAVRMFRGDYKLPSESEMKQDVEQKREAMASRYTESKRHTVQVDYPHYTDELADIIGVKPQFTKH 388
                 ****9985.578*************************************************************************************** PP

    FMO-like 452 llkdpklalkvffGpcspyqyrlvGpGkweGarkailtqwdrilkplktrvveessklvssfllkvfa.lvvllvall 528
                 l+kdp+l   ++  p  p  yr+        +      + ++++  +k    ++s++ +s+f  k++a + ++++ l+
  EFC39456.1 389 LIKDPQLGSLLLSSPAYPCTYRIEKETSLITSESHQKKEREQAINLIKHYRKQTSKDETSTF-GKILAiIKAVFFLLF 465
                 ***********************988888777777777777777777777777777766666.333331334444444 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.7   0.0   8.2e-16   2.5e-12      80     199 ..      18     155 ..       7     160 .. 0.81
   2 !    9.0   0.0   0.00024      0.73     212     281 ..     214     279 ..     211     292 .. 0.70
   3 ?   -3.9   0.1         2   6.1e+03      43      68 ..     415     440 ..     409     449 .. 0.49

  Alignments for each domain:
  == domain 1  score: 46.7 bits;  conditional E-value: 8.2e-16
  Pyr_redox_3  80 rkealeYlrevaksfelp..iklfeeVesvkk....edegfevetske....tyeAkkviiAtGefdkPnklnipGeek....lvkhyskvk...efh 160
                   ++++eYl+ +a++fel+  i+ +++Ve+++     + ++++v  +k+    + + +++++ tG  + Pn   ++G ++    +v+h++ +k   + +
   EFC39456.1  18 HEKVVEYLKLYAAKFELEqyIEFNTRVENIDLvnsgSTDKYKVIIRKGdqlsEETFDHIMVCTGHHSTPNIATFEGLKEnfkgNVIHSHSYKnpfDSD 115
                  67899************777*********98743233577*****9994333334579******************8854556688999998323446 PP

  Pyr_redox_3 161 kyagqkvvViGgknSavDaAlelvrk.gaeVtvvtrgsei 199
                   + +++v+V+G +nS+ D+A el+++  ++V + tr+ ++
   EFC39456.1 116 MFMNKNVLVVGIGNSGGDIAAELAKNvAKQVILSTRRGSW 155
                  688**********************977889999998766 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00024
  Pyr_redox_3 212 pdienrleelvkeekikvlfnaevkeikekeeeykvktedgkkvevkddvvlatGykpdlsflkkslfel 281
                  p+++++l + ++++ ++v+ n  + + +++   ++ ++e+ ++ ++ d vv++tGy+ ++ f+k+  fe+
   EFC39456.1 214 PTVNSELISKINNGVVRVVPN--IVRFSRD--GHTCRFENDENASNIDTVVICTGYRISFPFFKDGFFED 279
                  555666666666665665555..5555555..456777887888888999**************988876 PP

  == domain 3  score: -3.9 bits;  conditional E-value: 2
  Pyr_redox_3  43 mtfispsftsekleipdlnaiseets 68 
                  + +i+++ +++k   + +n i + ++
   EFC39456.1 415 TSLITSESHQKKEREQAINLIKHYRK 440
                  44555444444444444444444333 PP

>> K_oxygenase  L-lysine 6-monooxygenase (NADPH-requiring)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.3   0.0     7e-14   2.1e-10     100     226 ..      23     153 ..      13     159 .. 0.80
   2 !    3.7   0.0    0.0091        27     322     341 ..     247     266 ..     240     267 .. 0.87

  Alignments for each domain:
  == domain 1  score: 40.3 bits;  conditional E-value: 7e-14
  K_oxygenase 100 dYlrWvasqle..eqvrfgeeveevepdeeeeeelltveskdaegeeeelearnlvlgvG..tepkiPevlekle..gkervvHsseylerkee.lla 190
                  +Yl+  a+++e  + ++f+++ve+++ +++ +++ ++v  + + ++ +e +  ++++ +G  ++p+i + +e l+   k +v+Hs++y +  ++    
   EFC39456.1  23 EYLKLYAAKFEleQYIEFNTRVENIDLVNSGSTDKYKVIIR-KGDQLSEETFDHIMVCTGhhSTPNIAT-FEGLKenFKGNVIHSHSYKNPFDSdMFM 118
                  688888887765367**************998899****95.455566777789999999556777754.5555533469***********9885678 PP

  K_oxygenase 191 kkriaVvGsGqSaaeifedllrrqkkvelklvtrse 226
                  +k+++VvG G S+++i+ +l+++ + +++ l tr+ 
   EFC39456.1 119 NKNVLVVGIGNSGGDIAAELAKNVA-KQVILSTRRG 153
                  99********************987.6777877775 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0091
  K_oxygenase 322 esgeeetlevdavvlATGYr 341
                  ++++e+  ++d+vv++TGYr
   EFC39456.1 247 FENDENASNIDTVVICTGYR 266
                  57788999***********8 PP

>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.7   0.0   6.2e-11   1.8e-07      59     240 ..      30     268 ..       7     272 .. 0.66
   2 !    8.4   0.0   0.00039       1.2      54     114 ..     215     270 ..     176     306 .. 0.68

  Alignments for each domain:
  == domain 1  score: 30.7 bits;  conditional E-value: 6.2e-11
                  HHHCHHHHCCCCHCCTCEEEE.ESC.EEEEETEEECTCEEEEEESEEEE---..EEE-BCTCTTC.TTBEECCSECHHHHHHCCSS-T..SEEEEES- CS
                  xxxxxxxxxxxxxxxxxxxxx.xxx.xxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxx RF
  Pyr_redox_2  59 vvkklnqgielllgeevvkid.pgk.kkvklekkkegdeekiaydklvlAtG..ssprdlgipGvaenvgklvrtldsaealklkllp..krivvvGg 150
                     +l+q ie+ +++e +++   g+  k+k+  +k+++  + ++d+++++tG  s+p++ + +G++en   +v +++s +   +  +   k+++vvG 
   EFC39456.1  30 AKFELEQYIEFNTRVENIDLVnSGStDKYKVIIRKGDQLSEETFDHIMVCTGhhSTPNIATFEGLKENFKGNVIHSHSYKNPFDSDMFmnKNVLVVGI 127
                  446788889999996655544444456777777788899999**********87799999*****9999999999999888877777678******** PP

                  SHHHHHHHHHHHHH.T-EEE......................................................EEESSSSSSTTS-HHHHHHHHHHH CS
                  xxxxxxxxxxxxxx.xxxxx......................................................xxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 151 GyiGvElAaalakl.gkevt......................................................lveardrllraldkelsaaleeal 193
                  G+ G ++Aa+lak  +k+v                                                       ++  r r+  +++   s+    ++
   EFC39456.1 128 GNSGGDIAAELAKNvAKQVIlstrrgswiiprellgdpldhvprfawmlprrviqyaneflltlvngdlkkfskYLAPRHRFFGSHPTVNSEL-ISKI 224
                  **********86663776664555555555555555555555555555555555555555555555555555556677777764444333333.3333 PP

                  HHTTEEEEESCEEEEEEETTEEEE.EEETTSCEEEESEEEE-S-EEES CS
                  xxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 194 ekeGvevklgtsvkeidgngekle.vvledgeeidadlvvvavGvrps 240
                  ++  v+v+   +++++ ++g+  +   ++d++  + d+vv+++G+r+s
   EFC39456.1 225 NNGVVRVV--PNIVRFSRDGH--TcRFENDENASNIDTVVICTGYRIS 268
                  33233333..44446666665..4467777777788888888887776 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00039
                  HHHHHHHHCHHHH.CCCCHCCTCEEEEESCEEEEETEEECTCEEEEEESEEEE---EEE-BC CS
                  xxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2  54 eiasevvkklnqg.ielllgeevvkidpgkkkvklekkkegdeekiaydklvlAtGssprdl 114
                   + se ++k+n+g ++++ +  +v++ ++ +++  e+    de+    d++v++tG +   +
   EFC39456.1 215 TVNSELISKINNGvVRVVPN--IVRFSRDGHTCRFEN----DENASNIDTVVICTGYRISFP 270
                  33337788888884454444..888888887777744....445667888888888654444 PP

>> Prenylcys_lyase  Prenylcysteine lyase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.1   2.2e-05     0.066     142     201 ..      34      98 ..      19     110 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.2e-05
  Prenylcys_lyase 142 v.....inatVtsielksgessslYevtykkesgtesklyDiVviAtPlqkkesni.sfenfsppi 201
                      +      n++V++i+l +++s+ +Y+v   k  + +++++D +++ t  ++   ni +fe++++++
       EFC39456.1  34 LeqyieFNTRVENIDLVNSGSTDKYKVIIRKGDQLSEETFDHIMVCTGHHSTP-NIaTFEGLKENF 98 
                      444445799**********************99**************999554.551566666555 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.52   1.6e+03      58      93 ..      29      65 ..      18      74 .. 0.74
   2 ?    9.8   0.0   0.00027       0.8      10      44 ..     117     151 ..     109     154 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.52
                  .ET-EEEEGCGHHHHHHT-SEEEE.-SSSSS-SB-HH CS
  Shikimate_DH 58 geeiealkleelkellaeadvvis.ataseepileke 93
                  ++++e  ++ e +++++++d+v s +t   ++i++k+
    EFC39456.1 29 AAKFELEQYIEFNTRVENIDLVNSgSTDKYKVIIRKG 65
                  45578888999999******99884566667777765 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00027
                   .TT-EEEEES-SHHHHHHHHHHHCCT-CEEEEEES CS
  Shikimate_DH  10 lkekkvlliGaGemaelvakhLlakgvkkvvvaNR 44 
                   + +k+vl++G G+ +  +a  L+++ +k+v+   R
    EFC39456.1 117 FMNKNVLVVGIGNSGGDIAAELAKNVAKQVILSTR 151
                   6689************************9998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       947  (0.0528195); expected 358.6 (0.02)
Passed bias filter:                      671  (0.0374254); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.71u 0.35s 00:00:01.06 Elapsed: 00:00:00.55
# Mc/sec: 2655.80
//
Query:       EFC39457.1  [L=3743]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
   4.8e-126  411.8 194.7    1.6e-11   44.8   0.3   27.1 27  Big_9       Bacterial Ig domain
    1.2e-57  192.0 120.2    1.7e-06   27.9   0.9   23.3 24  Cadherin_5  Cadherin-like domain
    2.2e-56  188.4 132.4    8.9e-09   35.9   0.2   21.6 21  Cadherin_4  Bacterial cadherin-like domain
    9.6e-46  153.8 453.5    0.00019   21.7  15.3   22.3 22  EGF_2       EGF-like domain
    5.5e-23   82.1   0.2    1.9e-22   80.4   0.2    1.9  1  VWA         von Willebrand factor type A domain
    1.1e-11   45.3   0.3    3.6e-11   43.7   0.3    1.9  1  VWA_2       von Willebrand factor type A domain
  ------ inclusion threshold ------
       0.22   12.2   1.5        2.3    9.0   0.1    3.2  2  DUF2712     Protein of unknown function (DUF2712)
        4.6    7.2   7.5        1.6    8.7   0.0    3.9  4  DUF2808     Protein of unknown function (DUF2808)


Domain annotation for each model (and alignments):
>> Big_9  Bacterial Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.8   8.1e-06     0.018      40      86 ..      77     118 ..      35     122 .. 0.77
   2 !   32.3   0.4   5.4e-11   1.2e-07       6      87 ..     131     221 ..     128     224 .. 0.81
   3 !   31.9   3.5   7.6e-11   1.7e-07       2      88 ..     226     316 ..     225     318 .. 0.84
   4 !   20.5   3.1   2.7e-07    0.0006       1      88 [.     323     431 ..     323     433 .. 0.89
   5 !   44.0   6.0   1.3e-14   2.9e-11       5      89 ..     438     526 ..     436     527 .. 0.86
   6 !   10.9   0.5   0.00026      0.58       6      87 ..     533     618 ..     532     621 .. 0.72
   7 !   29.6   2.1   3.9e-10   8.8e-07       3      88 ..     626     718 ..     624     720 .. 0.77
   8 !   44.8   0.3   7.2e-15   1.6e-11       4      88 ..     725     816 ..     722     818 .. 0.84
   9 !   38.7   2.1   5.5e-13   1.2e-09       2      88 ..     820     910 ..     819     912 .. 0.83
  10 !   14.2   0.6   2.4e-05     0.054       3      88 ..     918    1012 ..     916    1014 .. 0.75
  11 ?    5.7   0.0     0.012        26       2      87 ..    1016    1104 ..    1015    1106 .. 0.70
  12 !    8.8   0.4    0.0012       2.8       8      88 ..    1117    1202 ..    1110    1203 .. 0.62
  13 !   10.4   0.7   0.00038      0.86       1      89 [.    1205    1287 ..    1205    1288 .. 0.81
  14 ?    2.0   0.1      0.16   3.5e+02       2      85 ..    1292    1377 ..    1290    1381 .. 0.63
  15 !    6.8   0.1    0.0051        11      11      88 ..    1393    1478 ..    1383    1480 .. 0.72
  16 !   11.7   0.1   0.00015      0.34      53      86 ..    1537    1570 ..    1518    1573 .. 0.85
  17 !   28.4   0.8   9.4e-10   2.1e-06       2      89 ..    1576    1669 ..    1575    1670 .. 0.85
  18 !   26.7   1.1     3e-09   6.8e-06       4      88 ..    1677    1800 ..    1674    1802 .. 0.89
  19 !   10.9   0.5   0.00027       0.6       3      72 ..    1805    1884 ..    1804    1894 .. 0.76
  20 !   23.7   1.3   2.6e-08   5.9e-05      31      89 ..    1899    1952 ..    1885    1953 .. 0.90
  21 !   28.5   6.4   8.6e-10   1.9e-06       6      88 ..    1959    2049 ..    1956    2051 .. 0.86
  22 !   18.8   2.4   9.3e-07    0.0021       3      88 ..    2054    2153 ..    2052    2154 .. 0.70
  23 !   29.9   0.4   3.2e-10   7.1e-07       5      89 ..    2160    2254 ..    2157    2255 .. 0.83
  24 !    9.4   0.5   0.00078       1.7      37      74 ..    2301    2335 ..    2261    2354 .. 0.76
  25 !   12.8   1.3   6.9e-05      0.15       1      89 [.    2356    2455 ..    2356    2456 .. 0.74
  26 !   12.6   0.1   8.1e-05      0.18       4      85 ..    2464    2553 ..    2461    2558 .. 0.78
  27 ?   -2.7   0.5       4.6     1e+04      20      72 ..    2832    2859 ..    2813    2900 .. 0.55

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 8.1e-06
       Big_9  40 altvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvs 86 
                 +     ++ ++  +p +G++ + +++t+ y  ++ fsg+d+f+Y v+
  EFC39457.1  77 D-----ISQQGLEKPYHGSLRLGSNNTIIYHSEKYFSGNDTFEYYVT 118
                 2.....23345567******************************998 PP

  == domain 2  score: 32.3 bits;  conditional E-value: 5.4e-11
       Big_9   6 vtvtpvndaPvavddsvtvtedsv.............landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsD 87 
                 v +   n+ P av+ +++++++s                  td d+d l+++s    ++t+   G+v+ +++ ++ ytp ++  g dsftYtv+D
  EFC39457.1 131 VSILVMNRDPKAVPLTFEIPKNSHdniidifekndkfGMKVTDDDDDILELVS----VSTPKLSGSVVSSNSKQIIYTPCTNCIGVDSFTYTVTD 221
                 5566669999999999999966666666665554454338999999**99654....589999*******9***********************9 PP

  == domain 3  score: 31.9 bits;  conditional E-value: 7.6e-11
       Big_9   2 atvtvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgt.ltytpna.gfsgtdsftYtvsDg 88 
                  + t+t++ vn++P av d++t++++ +     l+nd+d + d l + s   +++  ++ G+v++++d + l y p a      d f+Y ++D+
  EFC39457.1 226 VSSTITINLVNTPPNAVRDDFTISKNKLatlnvLSNDIDENLDELYIIS---AGTGEGSIGSVVVSTDRKsLIYYPKAdTKPYLDVFSYVITDD 316
                 57799*******************777777777************8654...567789999999996655599999994566789********6 PP

  == domain 4  score: 20.5 bits;  conditional E-value: 2.7e-07
       Big_9   1 tatvtvtvtpvndaPvavdds.vtvtedsv..landtdpdgdaltvtsltvtlvtapanGtvtinadgt....................ltytpnagfs 76 
                 t+t +++vt +n +P a ++  v+v+++s+  +   t  d+d l   +++v++ ++p+ G +++ ++                      l y+p++g s
  EFC39457.1 323 TSTGSIHVTVTNSPPNAPETKqVSVSKNSAnsTIDLTFTDNDILD--TVNVEILSTPKRGYFSFVQQKYidsvdylgqiyvdvlklryqLLYSPEKGVS 419
                 67888999999******9977799987777656677888999985..6889**************8877****************************** PP

       Big_9  77 gtdsftYtvsDg 88 
                  ++sf+++v+Dg
  EFC39457.1 420 YSESFNVKVTDG 431
                 ***********9 PP

  == domain 5  score: 44.0 bits;  conditional E-value: 1.3e-14
       Big_9   5 tvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDgs 89 
                 ++ ++ vn++P+ v+d++t t+++      ++nd d+dgd++++++  ++  ++ ++G v  ++d ++ty +++gf g d++ Y ++Dg+
  EFC39457.1 438 SIIINVVNTPPISVNDTITCTKNNEvvvdvISNDYDVDGDSIKLSTTDWEP-NSFNGGEVFRTDDRSITYKAPQGFVGIDTVRYYITDGE 526
                 5778999************9955555777799***********99877765.556688888888************************96 PP

  == domain 6  score: 10.9 bits;  conditional E-value: 0.00026
       Big_9   6 vtvtpvndaPvavddsvtvt.....edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpna.gfsgtdsftYtvsD 87 
                 +tv+ +  +P+av+d + v+       +vl+nd  p  d + + s+ +t+ +  +   v    ++ + y  +a +    d+f+Y+v D
  EFC39457.1 533 LTVNVQSVKPIAVNDVFFVPkglktFLNVLNNDYSPSKDEILL-SF-ATIRSVEESNVVRSLRNNVYGYEYSAsDVEYVDTFNYKVVD 618
                 46777799********9999554444455***********954.44.333444444444444577999988886788899******99 PP

  == domain 7  score: 29.6 bits;  conditional E-value: 3.9e-10
       Big_9   3 tvtvtvtpvndaPvavddsvtvt..edsv...landtdpdgda..ltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                 ++ vtv+ vn++P avdd ++v+   d v   l+nd d + ++  l v++ t+ +++++    v + +  +l  +p++gf+gt +f Y +sD+
  EFC39457.1 626 SAVVTVKVVNTPPKAVDDVISVSwnRDAVlnvLENDYDENPSDnqLLVVKRTIHGENQTVPTPVIFESGKKLLLSPPNGFTGTFEFFYVISDT 718
                 67899999***********9997665555666889999665540044555666666666666677777778*********************7 PP

  == domain 8  score: 44.8 bits;  conditional E-value: 7.2e-15
       Big_9   4 vtvtvtpvndaPvavddsvtvt......edsvlandtdpdgdaltvtsltvtlvtapanGtvtin..adgt....ltytpnagfsgtdsftYtvsDg 88 
                 ++vtv+ vn++P+a+dd+v+v+        +vl+nd+d dgd l ++s+     t+p++G v+ +  +dgt    ++  ++  f g dsf+Y ++D+
  EFC39457.1 725 AKVTVSIVNHQPIANDDHVSVHwrdgisVINVLQNDSDEDGDILLIKSF-----TQPSKGFVVKKalPDGTevfeYSILASVKFVGIDSFQYEITDN 816
                 68999999*************99887777777************87776.....7899998887767899999555555566**************7 PP

  == domain 9  score: 38.7 bits;  conditional E-value: 5.5e-13
       Big_9   2 atvtvtvtpvndaPvavddsvtvt......edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgt.ltytpnagfsgtdsftYtvsDg 88 
                 +t+tv v+ +n  Pva++ds++v+      e + l+nd d d d+l+++  ++ +  ++  G+ +inadgt + + p+   sg  ++tY++sD+
  EFC39457.1 820 STATVYVNVTNFSPVANEDSYNVHwnaeqqEYEILSNDFDGDSDPLKIVPNSL-IIPSQFRGQTEINADGTaIKFKPS--VSGVFTLTYRISDT 910
                 6788888888**********99987764444444**************98666.6677889*********97888876..56***********6 PP

  == domain 10  score: 14.2 bits;  conditional E-value: 2.4e-05
       Big_9    3 tvtvtvtpvndaPvavdds..vtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgt......ltytpnagfsgtdsftYtvs 86  
                  +vt++vt   d+P   + +  +  t +++     ++   d dgd l ++s   + v +p+nG+++  + g       l+y  n+gf+g+d +++  +
  EFC39457.1  918 KVTFNVT-NLDKPLLRTIEknIHWTMNQPisipiTTFTRDSDGDLLVISS---EFVKQPTNGSIESVNYGDantvpsLVYKKNPGFFGSDIIQVLLT 1010
                  5777777.456666666552333345555556666677889999997654...668999999999998888889999******************** PP

       Big_9   87 Dg 88  
                  Dg
  EFC39457.1 1011 DG 1012
                  *8 PP

  == domain 11  score: 5.7 bits;  conditional E-value: 0.012
       Big_9    2 atvtvtvtpvndaPvavdds........vtvt..edsv.landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsD 87  
                  a +t+ v+++n+ P  +++         +  +   +s+ +a + d d  ++     ++  + a +   +++n+d ++t++p +gf  + + +   sD
  EFC39457.1 1016 AIITIKVNSINQIPLCQSTIkesvfwkdL--PyvRNSLlIAGALDQDSEDI-----VYLKSVANSFNDISVNGD-EITFSPLKGFVEERNAQLIFSD 1104
                  66899999999999999877644333332..03233335667777777765.....466777889999****99.**********988776666666 PP

  == domain 12  score: 8.8 bits;  conditional E-value: 0.0012
       Big_9    8 vtpvndaPvavddsvtvt......edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgt...ltytpnagfs.gtdsftYtvsDg 88  
                  v   + +P a+++   ++        +vl++ +d+dgd+     +++++++  + G+++i  + +   + +t +++ + g+ +f++  +Dg
  EFC39457.1 1117 V--NDSKPQATPTISMIHwsksssLIDVLSTIVDADGDSCD---FSIKSQSDYSIGSASIELNANtkfVKWTVSNDKNlGESTFDIEFTDG 1202
                  3..3677777777744443322224455***********97...55666666555555555333335866777665542788*****9998 PP

  == domain 13  score: 10.4 bits;  conditional E-value: 0.00038
       Big_9    1 tatvtvtvtpvndaPvavddsvtvtedsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpna..gfsgtdsftYtvsDgs 89  
                  t+t+t  v+  n  P++ + +++v+    l nd     d++ ++    +l t p+ G v+  ++ t++y  ++  +  g+ +f Y+v+Dg+
  EFC39457.1 1205 TDTATYRVQVYNNIPIVPQKTIEVHWSKYL-ND---QEDTIYIA----ALLTEPSSGRVEKISTTTVRYYLPEdhSVLGDFTFRYSVTDGT 1287
                  567888888889999999999999988887.55...35677655....56899*******99999****999944555899********97 PP

  == domain 14  score: 2.0 bits;  conditional E-value: 0.16
       Big_9    2 atvtvtvtpvndaPvavddsvtvt........edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtv 85  
                  a+vtv++    d P+ ++ s +++        + + + +  d dgd +      +++v + + G ++i++d +l    ++   g+ + ++++
  EFC39457.1 1292 ANVTVDIV-NRDYPIDASISRSIHwreavsglAINIVPSKNDQDGDLI-----ILNIVESNNPGIFSISNDVNLLVKSEEPLKGDFNASVSI 1377
                  56677776.556777777775555432211224444667777777765.....6788999999*****999888887777555555555555 PP

  == domain 15  score: 6.8 bits;  conditional E-value: 0.0051
       Big_9   11 vndaPvavddsvtvtedsv..........landtdp.dgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88  
                   n+aP+  d  ++++  +            +nd+d  d ++l++++  +++ ++p+   vti ++ tl + p+  + g+ ++++ +sDg
  EFC39457.1 1393 YNHAPTSRDLYFNFHWSTIsrgvyidlvqRSNDIDLqDKSKLNIKH--AQVIAGPDANAVTIVNN-TLYFKPSILEIGNTTIEFIISDG 1478
                  5777777777766653333334466665666999852566677775..56778899999****55.**********************9 PP

  == domain 16  score: 11.7 bits;  conditional E-value: 0.00015
       Big_9   53 apanGtvtinadgtltytpnagfsgtdsftYtvs 86  
                  +  +G+v+i++  ++ty p ++f gt+ f ++ +
  EFC39457.1 1537 PDHGGQVSISTIRNVTYYPKENFVGTEVFAVSYT 1570
                  46789***********************998765 PP

  == domain 17  score: 28.4 bits;  conditional E-value: 9.4e-10
       Big_9    2 atvtvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtin.adgtltytpna..gfsgtdsftYtvsDgs 89  
                  +++tv+v+  n +P  ++ +++++  ++     l+ + d d  +  +  l  +l   ++ Gt++   +dg++t+tpn   gf gt +f Y+++Dg+
  EFC39457.1 1576 SNITVHVNVYNNNPQGAPKDYETHWRNPvlmniLNGAFDEDEYDR-F-YLFPELLEESTTGTLSQIaPDGSVTFTPNVtsGFIGTTTFYYRINDGN 1669
                  6799********************777777777777777777664.3.36678888899***98666**********999**************97 PP

  == domain 18  score: 26.7 bits;  conditional E-value: 3e-09
       Big_9    4 vtvtvtpvndaPvavddsvtvt....edsv.....landtdpdgdaltvtsltvtlvta................................panGtv 59  
                  vt+t++  n +P+  +  +++      d+v      +n td d d+l +  l v++ ++                                +a+Gtv
  EFC39457.1 1677 VTITIN--NNPPTSHTKVLNIMwknfLDGVdfdiiSTNPTDTDSDSLDIPFLFVKSFNQplpfgevsrlsssrvkvqgngdnvilkavihqAAKGTV 1771
                  777777..**********9998445544447777677***********99888877777************************************** PP

       Big_9   60 tinadgtltytpnagfsgtdsftYtvsDg 88  
                  +i ++ t+ y+ + +f g+dsft + sDg
  EFC39457.1 1772 SIIDSKTIKYQSSFSFKGSDSFTLQLSDG 1800
                  ****************************9 PP

  == domain 19  score: 10.9 bits;  conditional E-value: 0.00027
       Big_9    3 tvtvtvtpvndaPvavddsvtvt...edsv...landtd....pdgdaltvtsltvtlvtapanGtvtinadgtltytpn 72  
                  tv + +  +n  P+ +d s+++    +++v   l n td     d d l  ++lt+++ t+p+ G+v++++  +l++t +
  EFC39457.1 1805 TVDLEIDVTNNLPTLSDISIQTLhrlSGNViipLINRTDslkpKDLDILDNDKLTISAFTQPGIGSVVFSDATQLSFTFS 1884
                  788888889**********8886688666677744443311214666666677888899***********9999*99976 PP

  == domain 20  score: 23.7 bits;  conditional E-value: 2.6e-08
       Big_9   31 andtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDgs 89  
                  +n+ d+dgd+l v+s      t+p+ G+v+  ++  +t++p a  + t sf++tvsDg+
  EFC39457.1 1899 SNALDADGDNLFVKS-----FTQPSVGSVSSLNTSHVTFSPVAFKAFTTSFKFTVSDGA 1952
                  599********6665.....58**********9*9**********************96 PP

  == domain 21  score: 28.5 bits;  conditional E-value: 8.6e-10
       Big_9    6 vtvtpvndaPvavdds......vtvtedsvlandtdpdgdaltvtsltvtlvtapanGtvtinad.gtltytpna.gfsgtdsftYtvsDg 88  
                  ++++ +n++P avdds        v + s+l nd d ++d++t++   ++ v+     ++t+n+d  t+ty+ +    +g+dsf+Yt++Dg
  EFC39457.1 1959 FDISITNTNPKAVDDSlnklwsNKVFTFSPLVNDYDDNNDQITIVPELTEKVSRLRSASITVNSDlKTITYSDTGsLTTGSDSFSYTITDG 2049
                  456667**********87777766668888***************99999999999999***96626799998886789***********9 PP

  == domain 22  score: 18.8 bits;  conditional E-value: 9.3e-07
       Big_9    3 tvtvtvtpvndaPvavddsvtvtedsv......landtdpdgdaltvtsltvtlvtapanGtvtin..adgtltytpna...........gfsgtds 80  
                  ++ v +t +n+ P +++ +v+v+ d++      l    d dgdal+++ +     t++  Gt ++   + gt  ytpn            +++  d+
  EFC39457.1 2054 SAIVSITFTNTEPSVESFEVSVKWDQSitfdnlLGRCKDLDGDALSFAGI-----TQGMLGTTQLIdsQIGTSKYTPNRaltytnkpstgNWTVVDT 2145
                  455666667********998888555555555599**********86655.....44333333333124455666666666666666********** PP

       Big_9   81 ftYtvsDg 88  
                  ++Y+ +D+
  EFC39457.1 2146 IQYSCTDS 2153
                  ******96 PP

  == domain 23  score: 29.9 bits;  conditional E-value: 3.2e-10
       Big_9    5 tvtvtpvndaPvavdds...........vtvtedsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDgs 89  
                  t+ +t  n +P  +d s           ++++  s l++ +d +gd++t+t++ + + ++    +v++ ad ++ +   ++f g   f Yt+sDg+
  EFC39457.1 2160 TISITIYNEPPKGNDISisqvrnynnpqISIDGYSILSQSSDSNGDSITITKVKLYD-NQNIETSVVLQADSSIKFKYGKSFIGIQKFYYTISDGQ 2254
                  4555555********997666665555555555555*****************9975.6778999*****************************96 PP

  == domain 24  score: 9.4 bits;  conditional E-value: 0.00078
       Big_9   37 dgdaltvtsltvtlvtapanGtvtinadgtltytpnag 74  
                  dg +++vt +   ++t ++ Gt++   d+tltytpn+ 
  EFC39457.1 2301 DGEPISVT-V-SGTSTLSSVGTISTV-DNTLTYTPNKR 2335
                  78888755.2.3345669********.66*******84 PP

  == domain 25  score: 12.8 bits;  conditional E-value: 6.9e-05
       Big_9    1 tatvtvtvtpvndaPvavdds..vtvtedsv.........landtdpdgda.ltvtsltvtlvtapanGtvtinadgtltytpnagfsgtd.sftYt 84  
                  +at ++ v+  n+aP   + +  ++ + d+           a  tdpd ++  +++s+  +l + +++ t++++ +g++++t  a f  +  +f+++
  EFC39457.1 2356 SATCKIIVNQSNQAPNNPSYTykYSARRDGNnlmifdylvDAAVTDPDSTDsVSIQSI-SSLGSCSDKATISVS-NGKISFTRQATFLASTcTFNIK 2450
                  6899999999999999888886655554444568877754347777776440444443.445555999999999.9***********99888***** PP

       Big_9   85 vsDgs 89  
                   +D++
  EFC39457.1 2451 LQDDD 2455
                  *9986 PP

  == domain 26  score: 12.6 bits;  conditional E-value: 8.1e-05
       Big_9    4 vtvtvtpvndaPvavdds..vtvtedsv......landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtv 85  
                  +++tv+p+  +P av+d+  +t++++        l+nd+d  g + t++ l   ++t  +nG  t+ + +t++    +g    + ++Y++
  EFC39457.1 2464 ASITVNPTISPPLAVSDNimATFNSNRDidvsvlLQNDIDLLGGSFTFDGLFCPDATYCKNGLPTLLNANTVRIPFKTGSCEAEKVQYRI 2553
                  79****************655555333356678899************999999999888888888877787777777777777777766 PP

  == domain 27  score: -2.7 bits;  conditional E-value: 4.6
       Big_9   20 dsvtvt.edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpn 72  
                   ++tv+ ++ ++ n + ++ +                          t+ty  +
  EFC39457.1 2832 SQITVQySGRSVVNQSNIAST--------------------------TFTYVLT 2859
                  223332223333333333333..........................3333333 PP

>> Cadherin_5  Cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   0.0   0.00028      0.63      46      94 ..      83     130 ..      65     134 .. 0.82
   2 !   27.9   0.9   7.8e-10   1.7e-06      32      96 ..     170     233 ..     137     235 .. 0.87
   3 !    8.6   1.1    0.0008       1.8      15      97 ..     247     330 ..     233     333 .. 0.75
   4 !   20.4   1.4   1.7e-07   0.00038       2      86 ..     445     527 ..     444     538 .. 0.77
   5 ?   -1.2   0.2      0.88     2e+03      59      96 ..     593     630 ..     559     633 .. 0.58
   6 !    7.9   0.1    0.0014         3      25      96 ..     656     730 ..     634     731 .. 0.66
   7 !   25.9   0.4   3.3e-09   7.4e-06       1      98 []     732     829 ..     732     829 .. 0.77
   8 !   19.3   0.1   3.7e-07   0.00084      27      98 .]     851     924 ..     832     924 .. 0.81
   9 ?   -2.2   0.1       1.9   4.3e+03      34      67 ..     955     989 ..     951    1015 .. 0.76
  10 ?    3.2   0.0     0.038        86       2      84 ..    1026    1105 ..    1025    1118 .. 0.74
  11 ?    3.6   1.1     0.029        64      28      96 ..    1141    1213 ..    1117    1215 .. 0.72
  12 !   11.7   0.2   8.5e-05      0.19      38      97 ..    1238    1298 ..    1232    1299 .. 0.86
  13 ?    3.0   0.0     0.043        96      34      92 ..    1331    1387 ..    1323    1393 .. 0.79
  14 !    6.4   0.1    0.0038       8.4      28      88 ..    1418    1482 ..    1409    1490 .. 0.83
  15 ?    1.5   0.2      0.13   2.9e+02      41      84 ..    1531    1572 ..    1521    1584 .. 0.70
  16 !   20.3   0.1   1.8e-07   0.00041      29      97 ..    1608    1681 ..    1586    1682 .. 0.79
  17 !    9.5   0.3   0.00042      0.94      37      97 ..    1753    1812 ..    1749    1813 .. 0.87
  18 ?   -0.5   0.0      0.54   1.2e+03      36      69 ..    1853    1885 ..    1839    1895 .. 0.75
  19 !   21.9   0.3   5.5e-08   0.00012      32      97 ..    1900    1963 ..    1894    1964 .. 0.88
  20 !    9.4   3.6   0.00046         1       2      96 ..    1965    2060 ..    1964    2062 .. 0.71
  21 !   16.4   0.2   2.9e-06    0.0065       2      84 ..    2063    2145 ..    2062    2165 .. 0.66
  22 !   26.3   0.3   2.4e-09   5.4e-06       3      89 ..    2168    2258 ..    2166    2265 .. 0.76
  23 ?    1.3   0.0      0.15   3.4e+02      37      70 ..    2301    2335 ..    2295    2363 .. 0.69
  24 !    9.3   0.5   0.00047       1.1      21      92 ..    2387    2461 ..    2366    2469 .. 0.64

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00028
  Cadherin_5  46 ltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatas 94 
                 l+ +  +G++   ++ t+ ++ e+ ++G+ t++Y v+ ge+++ + +  
  EFC39457.1  83 LE-KPYHGSLRLGSNNTIIYHSEKYFSGNDTFEYYVTYGESSSLKVKNR 130
                 43.4569********************************9888776655 PP

  == domain 2  score: 27.9 bits;  conditional E-value: 7.8e-10
  Cadherin_5  32 nasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttataslt 96 
                 +++D d+d L+ +s+++ + +G+vv+ +  ++ +tp +n  G  +++Ytv+D + +t+++t++++
  EFC39457.1 170 KVTDDDDDILELVSVSTPKLSGSVVSSNSKQIIYTPCTNCIGVDSFTYTVTDFN-STVSSTITIN 233
                 689**************************************************8.6666777666 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.0008
  Cadherin_5  15 agseDtaltitaaqLLanasDvdgdtLsvssl.tadaenGtvvdngdG.tftftpeanynGev.tlsYtvsDg.eggtttatasltv 97 
                 ++s+++  t++   +L+n+ D + d+L + s  t + + G+vv   d  +  + p+a+ +  +  +sY ++D+ +   +t+t s++v
  EFC39457.1 247 TISKNKLATLN---VLSNDIDENLDELYIISAgTGEGSIGSVVVSTDRkSLIYYPKADTKPYLdVFSYVITDDlNNPNSTSTGSIHV 330
                 44555555555...9**************99966688889999888865899********887589******954456666666665 PP

  == domain 4  score: 20.4 bits;  conditional E-value: 1.7e-07
  Cadherin_5   2 ndaPvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvsslta...daenGtvvdngdGtftftpeanynGevtlsYtvsDgeg 86 
                 n  P+  ++ t+ + +++++++++   +++n+ Dvdgd+++ s  +    + + G+v +  d ++t++  + + G  t+ Y ++Dge+
  EFC39457.1 445 NTPPISVND-TI-TCTKNNEVVVD---VISNDYDVDGDSIKLSTTDWepnSFNGGEVFRTDDRSITYKAPQGFVGIDTVRYYITDGES 527
                 667766654.34.67778888887...9***********66655543223445699******************************85 PP

  == domain 5  score: -1.2 bits;  conditional E-value: 0.88
  Cadherin_5  59 gdGtftftpe.anynGevtlsYtvsDgeggtttataslt 96 
                  +  + ++   ++ +   t++Y+v D  g t+  +a +t
  EFC39457.1 593 RNNVYGYEYSaSDVEYVDTFNYKVVDVFGLTS-DSAVVT 630
                 5555555543145555669*******996544.555554 PP

  == domain 6  score: 7.9 bits;  conditional E-value: 0.0014
  Cadherin_5  25 taaqLLanasDvd.gdt.LsvssltadaenGtvv...dngdG.tftftpeanynGevtlsYtvsDgeggtttataslt 96 
                 +   +L+n+ D + +d+ L v++ t++ en tv      + G +  + p + ++G+ ++ Y +sD+  ++  a+++++
  EFC39457.1 656 N---VLENDYDENpSDNqLLVVKRTIHGENQTVPtpvIFESGkKLLLSPPNGFTGTFEFFYVISDTFDESNVAKVTVS 730
                 3...7888888876444566666667665655533333444438999*******************988887777765 PP

  == domain 7  score: 25.9 bits;  conditional E-value: 3.3e-09
  Cadherin_5   1 vndaPvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvssltadaenGtvvdn..gdGtftft....peanynGevtlsYtvsDgeggtttata 93 
                 vn++P+++++ +++    D   +i+   +L+n+sD dgd L ++s t+ + +G vv++   dGt +f+        + G  +++Y+++D+ g+++tat+
  EFC39457.1 732 VNHQPIANDD-HVSVHWRDGISVIN---VLQNDSDEDGDILLIKSFTQPS-KGFVVKKalPDGTEVFEysilASVKFVGIDSFQYEITDN-GKSSTATV 824
                 6888888876.44456667767777...******************8666.9****6522699855551111668999***********9.89999999 PP

  Cadherin_5  94 sltva 98 
                  ++v+
  EFC39457.1 825 YVNVT 829
                 99885 PP

  == domain 8  score: 19.3 bits;  conditional E-value: 3.7e-07
  Cadherin_5  27 aqLLanasDvdgdtLsv..sslta.daenGtvvdngdGt.ftftpeanynGevtlsYtvsDgeggtttatasltva 98 
                  ++L+n+ D d+d L++  +sl + ++  G++  n+dGt + f+p    +G  tl+Y++sD+ +++ +++++++v+
  EFC39457.1 851 YEILSNDFDGDSDPLKIvpNSLIIpSQFRGQTEINADGTaIKFKP--SVSGVFTLTYRISDTVSQSLDTKVTFNVT 924
                 469*************9433453357779*********7245666..589**********************9996 PP

  == domain 9  score: -2.2 bits;  conditional E-value: 1.9
  Cadherin_5  34 sDvdgdtLsvssl.tadaenGtvvdngdGtftftp 67 
                  D dgd L +ss    + +nG++ + + G+    p
  EFC39457.1 955 RDSDGDLLVISSEfVKQPTNGSIESVNYGDANTVP 989
                 699*******9853557779999876666655555 PP

  == domain 10  score: 3.2 bits;  conditional E-value: 0.038
  Cadherin_5    2 ndaPvvssevtlaagseDtaltitaaqLLanasDvd.gdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDg 84  
                  n+ P ++s+++ +   +D +++ + + L+a+a D d +d +  +s+  +++  ++  ngd  +tf p + +  e + +   sDg
  EFC39457.1 1026 NQIPLCQSTIKESVFWKDLPYVRN-SLLIAGALDQDsEDIVYLKSV--ANSFNDISVNGDE-ITFSPLKGFVEERNAQLIFSDG 1105
                  677777777777777778887655.889********6677889999..4557899999986.9999999888777777777776 PP

  == domain 11  score: 3.6 bits;  conditional E-value: 0.029
  Cadherin_5   28 qLLanasDvdgdt..Lsvssl.tadaenGtvvdngdG...tftftpeanyn.GevtlsYtvsDgeggtttataslt 96  
                  ++L+ + D+dgd+   s++s  +++ +++++  n++    ++t+  ++  n Ge t++ + +Dg   t tat  ++
  EFC39457.1 1141 DVLSTIVDADGDScdFSIKSQsDYSIGSASIELNANTkfvKWTVSNDK--NlGESTFDIEFTDGY-LTDTATYRVQ 1213
                  6999********9999**998567788889999999833334444444..459***********6.5666665555 PP

  == domain 12  score: 11.7 bits;  conditional E-value: 8.5e-05
  Cadherin_5   38 gdtLsvssltadaenGtvvdngdGtftftpeanyn..GevtlsYtvsDgeggtttatasltv 97  
                  +dt+ +++l ++ ++G v + +  t+ +   ++ +  G+ t+ Y+v+Dg+ ++++a++++++
  EFC39457.1 1238 EDTIYIAALLTEPSSGRVEKISTTTVRYYLPEDHSvlGDFTFRYSVTDGT-EIAEANVTVDI 1298
                  69999999988999******99999999988887777************7.88888888775 PP

  == domain 13  score: 3.0 bits;  conditional E-value: 0.043
  Cadherin_5   34 sDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttat 92  
                   D dgd L + ++  +++ G +   +d +  ++ e+  +G+ + s ++ Dg  ++++a 
  EFC39457.1 1331 NDQDGD-LIILNIVESNNPGIFSISNDVNLLVKSEEPLKGDFNASVSIFDGI-SVANAH 1387
                  678887.556666567779********************************6.444444 PP

  == domain 14  score: 6.4 bits;  conditional E-value: 0.0038
  Cadherin_5   28 qLLanasDvd.gdt..Lsvssl.tadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggt 88  
                  +L++   D+d +d+  L+++    ++  +++ v+  + t  f+p     G++t+++ +sDg   +
  EFC39457.1 1418 DLVQRSNDIDlQDKskLNIKHAqVIAGPDANAVTIVNNTLYFKPSILEIGNTTIEFIISDGFEDS 1482
                  5788888888766667***99844567788999999*************************7554 PP

  == domain 15  score: 1.5 bits;  conditional E-value: 0.13
  Cadherin_5   41 LsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDg 84  
                  L v +l   ++ G+v      ++t+ p++n+ G+  +  + + g
  EFC39457.1 1531 LDVIQL--PDHGGQVSISTIRNVTYYPKENFVGTEVFAVSYTTG 1572
                  455555..44479999999999***********98776544444 PP

  == domain 16  score: 20.3 bits;  conditional E-value: 1.8e-07
  Cadherin_5   29 LLanasDvd.gdtLsv.ssltadaenGtvv.dngdGtftftpe..anynGevtlsYtvsDgeggtttatasltv 97  
                  +L++a D d  d      +l  ++++Gt+     dG++tftp+  + + G++t+ Y+++Dg+  + ++ +++t+
  EFC39457.1 1608 ILNGAFDEDeYDRFYLfPELLEESTTGTLSqIAPDGSVTFTPNvtSGFIGTTTFYYRINDGNKVSLPTPVTITI 1681
                  78888888855663332455567789**995579********8557899*************999999999988 PP

  == domain 17  score: 9.5 bits;  conditional E-value: 0.00042
  Cadherin_5   37 dgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasltv 97  
                  +gd++  +++  +a++Gtv      t+ ++    ++G+ +++ + sDg  + +t  ++++v
  EFC39457.1 1753 NGDNVILKAVIHQAAKGTVSIIDSKTIKYQSSFSFKGSDSFTLQLSDGY-NLVTVDLEIDV 1812
                  5788888888888899********************************7.77777777776 PP

  == domain 18  score: -0.5 bits;  conditional E-value: 0.54
  Cadherin_5   36 vdgdtLsvssltadaenGtvvdngdGtftftpea 69  
                   d+d+L++s+ t+  + G+vv     + +ft  +
  EFC39457.1 1853 LDNDKLTISAFTQ-PGIGSVVFSDATQLSFTFSN 1885
                  489********85.55999997777777776555 PP

  == domain 19  score: 21.9 bits;  conditional E-value: 5.5e-08
  Cadherin_5   32 nasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasltv 97  
                  na D+dgd+L v+s t+ +  G+v + +   +tf p a    ++++++tvsDg  ++++++ ++++
  EFC39457.1 1900 NALDADGDNLFVKSFTQPS-VGSVSSLNTSHVTFSPVAFKAFTTSFKFTVSDGA-QQVEKQFDISI 1963
                  899************8665.9*****************9999***********6.67777766665 PP

  == domain 20  score: 9.4 bits;  conditional E-value: 0.00046
  Cadherin_5    2 ndaPvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvs.slta...daenGtvvdngdG.tftftpeanyn.GevtlsYtvsDgeggtttat 92  
                  n +P++ ++ +l++   ++ +t++    L n+ D ++d+++++ +lt    + ++++++ n+d  t+t+  +   + G+ ++sYt++Dg  +t++a 
  EFC39457.1 1965 NTNPKAVDD-SLNKLWSNKVFTFS---PLVNDYDDNNDQITIVpELTEkvsRLRSASITVNSDLkTITYSDTGSLTtGSDSFSYTITDGV-ATSSAI 2056
                  666666655.66666677777777...577888888999887524544333445799**999965999999987655************7.666677 PP

  Cadherin_5   93 aslt 96  
                  +s+t
  EFC39457.1 2057 VSIT 2060
                  7766 PP

  == domain 21  score: 16.4 bits;  conditional E-value: 2.9e-06
  Cadherin_5    2 ndaPvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvsslta.daenGtvvdngdGtftftpeanyn...GevtlsYtvsDg 84  
                  n +P v+s  ++ +++ D+++t++  +LL   +D dgd+Ls +++t+   ++ +++d + Gt  +tp+   +    + t ++tv D+
  EFC39457.1 2063 NTEPSVES-FEV-SVKWDQSITFD--NLLGRCKDLDGDALSFAGITQgMLGTTQLIDSQIGTSKYTPNRALTytnKPSTGNWTVVDT 2145
                  67777775.344.78889999988..9******************763334456779999999999986543222233334444443 PP

  == domain 22  score: 26.3 bits;  conditional E-value: 2.4e-09
  Cadherin_5    3 daPvvssevtlaagse..DtaltitaaqLLanasDvdgdtLsvsslta...daenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtt 89  
                  + P+ ++ ++++++++  + ++ i+  ++L++ sD +gd+++++++++   ++ + +vv ++d ++ f+  + + G  ++ Yt+sDg+ + t
  EFC39457.1 2168 EPPKGND-ISISQVRNynNPQISIDGYSILSQSSDSNGDSITITKVKLydnQNIETSVVLQADSSIKFKYGKSFIGIQKFYYTISDGQLENT 2258
                  5555554.3333333311558999999******************976544566799******************************84433 PP

  == domain 23  score: 1.3 bits;  conditional E-value: 0.15
  Cadherin_5   37 dgdt..LsvssltadaenGtvvdngdGtftftpean 70  
                  dg+   ++vs+ ++ ++ Gt+ +  d t t+tp++ 
  EFC39457.1 2301 DGEPisVTVSGTSTLSSVGTIST-VDNTLTYTPNKR 2335
                  44441156667766677899886.99*******986 PP

  == domain 24  score: 9.3 bits;  conditional E-value: 0.00047
  Cadherin_5   21 altitaaqLLanasDvd.gdtLsvsslta...daenGtvvdngdGtftftpeanyn.GevtlsYtvsDgeggtttat 92  
                  +l+i    + a ++D+d  d++s++s++     ++++t+   ++G+++ft +a +   + t++ + +D+  + t+at
  EFC39457.1 2387 NLMIFDYLVDAAVTDPDsTDSVSIQSISSlgsCSDKATIS-VSNGKISFTRQATFLaSTCTFNIKLQDDD-ELTPAT 2461
                  4555544445789****88999999986544444456665.49************735679*****9997.444443 PP

>> Cadherin_4  Bacterial cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1     0.096   2.2e+02       5      68 ..     131     199 ..     129     203 .. 0.73
   2 !   28.1   3.0     1e-09   2.3e-06       4      67 ..     229     290 ..     226     292 .. 0.89
   3 ?    4.6   1.4     0.022        50       2      61 ..     325     381 ..     324     390 .. 0.75
   4 !   30.2   6.2   2.4e-10   5.3e-07       4      72 .]     438     506 ..     437     506 .. 0.81
   5 !   11.4   0.0   0.00018       0.4       5      54 ..     533     581 ..     532     599 .. 0.87
   6 !   22.2   0.9   7.4e-08   0.00017       3      58 ..     627     681 ..     625     711 .. 0.80
   7 !   35.9   0.2     4e-12   8.9e-09       4      66 ..     726     785 ..     724     793 .. 0.89
   8 !   27.7   0.6   1.4e-09   3.1e-06       2      69 ..     821     889 ..     820     891 .. 0.83
   9 ?    1.0   0.2      0.29   6.6e+02       3      63 ..     919     978 ..     917     986 .. 0.64
  10 ?    2.6   0.0     0.095   2.1e+02      34      67 ..    1140    1176 ..    1113    1180 .. 0.63
  11 ?    0.0   0.7      0.61   1.4e+03       2      67 ..    1291    1356 ..    1290    1358 .. 0.80
  12 !    9.0   0.0   0.00095       2.1       2      72 .]    1577    1647 ..    1576    1647 .. 0.86
  13 ?    4.9   0.6     0.019        42       5      67 ..    1677    1776 ..    1675    1781 .. 0.58
  14 !   10.7   1.0   0.00029      0.65       2      67 ..    1805    1876 ..    1804    1883 .. 0.74
  15 !   11.2   0.7    0.0002      0.44      25      67 ..    1875    1927 ..    1870    1932 .. 0.84
  16 !   11.7   2.5   0.00014      0.31       5      58 ..    1959    2023 ..    1957    2044 .. 0.64
  17 !   21.1   0.1   1.6e-07   0.00036       5      64 ..    2057    2113 ..    2053    2140 .. 0.85
  18 !   11.2   1.2    0.0002      0.44       4      71 ..    2160    2233 ..    2158    2234 .. 0.78
  19 ?   -3.5   1.3       7.5   1.7e+04      40      63 ..    2299    2322 ..    2276    2330 .. 0.57
  20 !    6.5   0.2    0.0059        13       1      62 [.    2357    2432 ..    2357    2441 .. 0.63
  21 !   15.1   0.1   1.2e-05     0.026       4      53 ..    2465    2514 ..    2463    2563 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.096
  Cadherin_4   5 itvtgvndaPvavddsatvtedtpltitagnvl.......andtDvdgddltvtavtvagtyGtltlnadG 68 
                 +++   n +P av+ +++++ ++  +i   ++           tD d+d l  ++v++    G+++ +++ 
  EFC39457.1 131 VSILVMNRDPKAVPLTFEIPKNSHDNII--DIFekndkfgMKVTDDDDDILELVSVSTPKLSGSVVSSNSK 199
                 5677789999999999999997777752..33343333335689999999*******99999999877665 PP

  == domain 2  score: 28.1 bits;  conditional E-value: 1e-09
  Cadherin_4   4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtav.tvagtyGtltlnad 67 
                 tit++ vn +P av d +t+  +  +t    nvl+nd D + d+l + ++ t+ g+ G+++++ d
  EFC39457.1 229 TITINLVNTPPNAVRDDFTISKNKLATL---NVLSNDIDENLDELYIISAgTGEGSIGSVVVSTD 290
                 9***************************...*************8776651558899***99876 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.022
  Cadherin_4   2 tvtitvtgvndaPvavdd.satvtedtpltitagnvlandtDvdgddltvtavtvagtyGt 61 
                 t +i+vt +n +P a     ++v  +++ ++   +++ +d+D+  d++ v +++ ++  G 
  EFC39457.1 325 TGSIHVTVTNSPPNAPETkQVSVSKNSANST--IDLTFTDNDI-LDTVNVEILS-TPKRGY 381
                 779***********98762578888766554..4888777777.6778888887.677665 PP

  == domain 4  score: 30.2 bits;  conditional E-value: 2.4e-10
  Cadherin_4   4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvag...tyGtltlnadGsftY 72 
                 +i ++ vn +P+ v+d++t+t ++ +++   +v++nd+Dvdgd++  ++++  +   ++G++   +d s+tY
  EFC39457.1 438 SIIINVVNTPPISVNDTITCTKNNEVVV---DVISNDYDVDGDSIKLSTTDWEPnsfNGGEVFRTDDRSITY 506
                 799*************************...9************6555555444334667777777777777 PP

  == domain 5  score: 11.4 bits;  conditional E-value: 0.00018
  Cadherin_4   5 itvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd..ltvtavt 54 
                 +tv+ +   P+av+d++ v+ +  +     nvl+nd+ +  d+  l++++++
  EFC39457.1 533 LTVNVQSVKPIAVNDVFFVPKGLKTFL---NVLNNDYSPSKDEilLSFATIR 581
                 58999999*************999988...99********999877776654 PP

  == domain 6  score: 22.2 bits;  conditional E-value: 7.4e-08
  Cadherin_4   3 vtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd..ltvtavtvagt 58 
                 + +tv  vn +P avdd+++v  +  ++    nvl+nd+D +  d  l v+  t+ g+
  EFC39457.1 627 AVVTVKVVNTPPKAVDDVISVSWNRDAVL---NVLENDYDENPSDnqLLVVKRTIHGE 681
                 579********************999999...99******774432466666666555 PP

  == domain 7  score: 35.9 bits;  conditional E-value: 4e-12
  Cadherin_4   4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlna 66 
                  +tv  vn +P+a+dd ++v   + +++   nvl nd+D dgd l ++++t ++++G ++  a
  EFC39457.1 726 KVTVSIVNHQPIANDDHVSVHWRDGISV--INVLQNDSDEDGDILLIKSFT-QPSKGFVVKKA 785
                 69*******************9888888..5********************.*****988655 PP

  == domain 8  score: 27.7 bits;  conditional E-value: 1.4e-09
  Cadherin_4   2 tvtitvtgvndaPvavddsatv...tedtpltitagnvlandtDvdgddltvtavtv.agty..GtltlnadGs 69 
                 t+t+ v+ +n +Pva+ ds++v   +e++   i     l+nd D d+d+l ++  ++  +++  G+  +nadG+
  EFC39457.1 821 TATVYVNVTNFSPVANEDSYNVhwnAEQQEYEI-----LSNDFDGDSDPLKIVPNSLiIPSQfrGQTEINADGT 889
                 889999999************955455666666.....**************999854555556*********9 PP

  == domain 9  score: 1.0 bits;  conditional E-value: 0.29
  Cadherin_4   3 vtitvtgvndaPv..avddsatvtedtpltitagnvlandtDvdgddltvtavtv.agtyGtlt 63 
                 vt++vt   d P   +   ++  t ++p++i+   +++   D dgd l +++  v ++t+G++ 
  EFC39457.1 919 VTFNVT-NLDKPLlrTIEKNIHWTMNQPISIP---ITTFTRDSDGDLLVISSEFVkQPTNGSIE 978
                 555555.2355653445567778889999997...44445677777777655444499999875 PP

  == domain 10  score: 2.6 bits;  conditional E-value: 0.095
  Cadherin_4   34 gnvlandtDvdgdd..ltvtavtvagty....Gtltlnad 67  
                   +vl++ +D+dgd+  +++++ +   +y     ++ lna+
  EFC39457.1 1140 IDVLSTIVDADGDScdFSIKSQS---DYsigsASIELNAN 1176
                  48************555555444...34232234555555 PP

  == domain 11  score: 0.0 bits;  conditional E-value: 0.61
  Cadherin_4    2 tvtitvtgvn.daPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlnad 67  
                   +++tv+ vn d P+ +  s ++   +++++ a n+    +D dgd +  ++v  +++ G +++++d
  EFC39457.1 1291 EANVTVDIVNrDYPIDASISRSIHWREAVSGLAINIVPSKNDQDGDLIILNIVE-SNNPGIFSISND 1356
                  678999999857799888888888888888888899999999999998888887.677788888766 PP

  == domain 12  score: 9.0 bits;  conditional E-value: 0.00095
  Cadherin_4    2 tvtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd...ltvtavtvagtyGtlt.lnadGsftY 72  
                  ++t++v+  n++P  ++  +++   +p+     n+l+ + D d  d   l    +    t Gtl+ + +dGs+t+
  EFC39457.1 1577 NITVHVNVYNNNPQGAPKDYETHWRNPVLM---NILNGAFDEDEYDrfyLFPELLE-ESTTGTLSqIAPDGSVTF 1647
                  68****************************...9*********8776644445555.9999**984677****98 PP

  == domain 13  score: 4.9 bits;  conditional E-value: 0.019
  Cadherin_4    5 itvtgvndaPvavddsatvtedtpltita.gnvlandtDvdgddl......................tvtavt..................vagtyG 60  
                  +t+t  n++P+    + ++   + l + + + + +n tD d+d+l                      +    +                   ++++G
  EFC39457.1 1677 VTITINNNPPTSHTKVLNIMWKNFLDGVDfDIISTNPTDTDSDSLdipflfvksfnqplpfgevsrlS----SsrvkvqgngdnvilkaviHQAAKG 1769
                  677777***********999988888877455558888888888655555444444444444444441....0333333333333333332344557 PP

  Cadherin_4   61 tltlnad 67  
                  t+++ ++
  EFC39457.1 1770 TVSIIDS 1776
                  7777555 PP

  == domain 14  score: 10.7 bits;  conditional E-value: 0.00029
  Cadherin_4    2 tvtitvtgvndaPvavddsatvtedtplt......itagnvlandtD.vdgddltvtavtvagtyGtltlnad 67  
                  tv++ ++ +n+ P+ +d s+++    + +      + ++++   d D  d+d lt++a+t ++  G++++++ 
  EFC39457.1 1805 TVDLEIDVTNNLPTLSDISIQTLHRLSGNviipliNRTDSLKPKDLDiLDNDKLTISAFT-QPGIGSVVFSDA 1876
                  899*****************997754444222221333555566777557888*******.9******99875 PP

  == domain 15  score: 11.2 bits;  conditional E-value: 0.0002
  Cadherin_4   25 edtpltitagnvl...........andtDvdgddltvtavtvagtyGtltlnad 67  
                  + t+l++t  nvl           +n+ D+dgd l v+++t +++ G+++  ++
  EFC39457.1 1875 DATQLSFTFSNVLggsialdilkeSNALDADGDNLFVKSFT-QPSVGSVSSLNT 1927
                  5678888778999999999999*******************.*****9986555 PP

  == domain 16  score: 11.7 bits;  conditional E-value: 0.00014
  Cadherin_4    5 itvtgvndaPvavddsa.tvtedtpltitagnvlandtDvdgddltvtavt.............vagt 58  
                  +++  +n +P avdds      +  +t+   + l nd+D ++d++t++                v+ +
  EFC39457.1 1959 FDISITNTNPKAVDDSLnKLWSNKVFTF---SPLVNDYDDNNDQITIVPELtekvsrlrsasitVNSD 2023
                  578889**********747899******...89***********988765312322222222222222 PP

  == domain 17  score: 21.1 bits;  conditional E-value: 1.6e-07
  Cadherin_4    5 itvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltl 64  
                  +++t +n  P ++   ++v  d+++t+  +n+l+   D dgd+l+++++t +g  Gt  l
  EFC39457.1 2057 VSITFTNTEPSVESFEVSVKWDQSITF--DNLLGRCKDLDGDALSFAGIT-QGMLGTTQL 2113
                  788999*********************..6*******************9.887776443 PP

  == domain 18  score: 11.2 bits;  conditional E-value: 0.0002
  Cadherin_4    4 titvtgvndaPvavddsatvte...dtpltitagnvlandtDvdgddltvtavtv.agty..GtltlnadGsft 71  
                  ti++t  n +P  +d s++      + +++i+  ++l+  +D +gd++t+t v++ ++++   +++l+ad s+ 
  EFC39457.1 2160 TISITIYNEPPKGNDISISQVRnynNPQISIDGYSILSQSSDSNGDSITITKVKLyDNQNieTSVVLQADSSIK 2233
                  8999999*********996443354677888889*******************864333333788888887765 PP

  == domain 19  score: -3.5 bits;  conditional E-value: 7.5
  Cadherin_4   40 dtDvdgddltvtavtvagtyGtlt 63  
                  + D +  ++tv+++++  + Gt++
  EFC39457.1 2299 AFDGEPISVTVSGTSTLSSVGTIS 2322
                  455544456667777666777765 PP

  == domain 20  score: 6.5 bits;  conditional E-value: 0.0059
  Cadherin_4    1 atvtitvtgvndaPvavddsa..tv.tedtpltitagnvl..andtDvdgdd.ltvtavt..........vagtyGtl 62  
                  at  i v+  n+aP     ++  ++  +++ l i   + l  a  tD+d+ d +++++++          ++ ++G +
  EFC39457.1 2357 ATCKIIVNQSNQAPNNPSYTYkySArRDGNNLMIF--DYLvdAAVTDPDSTDsVSIQSISslgscsdkatISVSNGKI 2432
                  78999*********977776633331334555554..33345889****7777****998333333333233344544 PP

  == domain 21  score: 15.1 bits;  conditional E-value: 1.2e-05
  Cadherin_4    4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtav 53  
                  +itv+++  +P av d++ +t ++   i+   +l nd D  g+++t+ ++
  EFC39457.1 2465 SITVNPTISPPLAVSDNIMATFNSNRDIDVSVLLQNDIDLLGGSFTFDGL 2514
                  8***************997777777777667999*********9998875 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.6   2.1         8   1.8e+04      14      22 ..    2695    2701 ..    2694    2706 .. 0.73
   2 !   17.8  10.8   1.4e-06    0.0032       1      32 []    2973    3005 ..    2973    3005 .. 0.87
   3 !   12.0  12.9   9.2e-05      0.21       5      32 .]    3016    3044 ..    3010    3044 .. 0.87
   4 !   13.7  10.1   2.8e-05     0.062       6      32 .]    3058    3085 ..    3053    3085 .. 0.88
   5 !   12.1  12.9   8.5e-05      0.19       5      32 .]    3096    3124 ..    3090    3124 .. 0.89
   6 !   14.1  10.2     2e-05     0.045       6      32 .]    3138    3165 ..    3133    3165 .. 0.88
   7 !   13.7   7.7   2.8e-05     0.063       7      32 .]    3180    3206 ..    3173    3206 .. 0.88
   8 !   12.4  10.9     7e-05      0.16       6      32 .]    3220    3247 ..    3216    3247 .. 0.90
   9 !   12.1  13.6   8.9e-05       0.2       5      32 .]    3258    3286 ..    3252    3286 .. 0.90
  10 !    9.1  15.3   0.00073       1.6       1      32 []    3291    3325 ..    3291    3325 .. 0.91
  11 !   12.2  14.2   8.3e-05      0.19       5      32 .]    3336    3364 ..    3330    3364 .. 0.89
  12 !   17.5  16.9   1.8e-06    0.0039       1      32 []    3369    3396 ..    3369    3396 .. 0.94
  13 !   12.8  14.6   5.2e-05      0.12       5      32 .]    3407    3435 ..    3401    3435 .. 0.89
  14 !   13.6  15.6   2.9e-05     0.064       1      32 []    3440    3466 ..    3438    3466 .. 0.85
  15 !   10.0  19.4   0.00039      0.87       1      32 []    3477    3503 ..    3472    3503 .. 0.81
  16 !   11.7  18.1   0.00011      0.25       1      32 []    3508    3534 ..    3507    3534 .. 0.87
  17 !   12.8  15.8   5.3e-05      0.12       1      32 []    3539    3565 ..    3537    3565 .. 0.87
  18 !   16.2  13.7   4.5e-06      0.01       1      32 []    3570    3596 ..    3570    3596 .. 0.88
  19 !   18.2  17.1   1.1e-06    0.0025       1      32 []    3596    3627 ..    3596    3627 .. 0.95
  20 !   21.7  15.3   8.3e-08   0.00019       1      32 []    3627    3658 ..    3627    3658 .. 0.96
  21 !   21.1  15.3   1.3e-07    0.0003       1      32 []    3663    3690 ..    3659    3690 .. 0.91
  22 ?    5.2   9.9     0.013        29       8      32 .]    3709    3732 ..    3702    3732 .. 0.82

  Alignments for each domain:
  == domain 1  score: -4.6 bits;  conditional E-value: 8
       EGF_2   14 CvnqcGqCd 22  
                  C   cG+C+
  EFC39457.1 2695 CS--CGECK 2701
                  77..88774 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 1.4e-06
       EGF_2    1 Csas..deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C a    + C+ghG Cv++   C+C+sgy+G  C
  EFC39457.1 2973 CFAKsgASSCSGHGLCVQPD-LCQCNSGYTGTEC 3005
                  555556778********888.9************ PP

  == domain 3  score: 12.0 bits;  conditional E-value: 9.2e-05
       EGF_2    5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  + +C+g   GtC  ++  C+C++g++G +C
  EFC39457.1 3016 NFACSGtsKGTCTGPN-TCQCQTGWTGTDC 3044
                  778***99*****888.9************ PP

  == domain 4  score: 13.7 bits;  conditional E-value: 2.8e-05
       EGF_2    6 eiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                    C+g   GtC+++   C+C++g++G +C
  EFC39457.1 3058 GSCSGssKGTCISKD-TCQCQTGWTGSDC 3085
                  5699999*****888.9************ PP

  == domain 5  score: 12.1 bits;  conditional E-value: 8.5e-05
       EGF_2    5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  +++C+g  +G+C+++   C+C++g++G+ C
  EFC39457.1 3096 SSACSGpsQGSCISKD-TCQCQTGWTGPEC 3124
                  789**********888.9************ PP

  == domain 6  score: 14.1 bits;  conditional E-value: 2e-05
       EGF_2    6 eiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                    C+g   GtC+++   C+C++g++G +C
  EFC39457.1 3138 GSCSGssKGTCISKD-TCQCQDGWTGSDC 3165
                  5699999*****888.9************ PP

  == domain 7  score: 13.7 bits;  conditional E-value: 2.8e-05
       EGF_2    7 iCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                   C+g   GtCv++   C+C++g++G +C
  EFC39457.1 3180 SCSGssKGTCVSKS-SCSCQTGWTGFDC 3206
                  5999889****888.7************ PP

  == domain 8  score: 12.4 bits;  conditional E-value: 7e-05
       EGF_2    6 eiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  + Cgg  +G+C ++   C+C++g++G +C
  EFC39457.1 3220 SVCGGssRGSCTSKD-TCQCQTGWTGSDC 3247
                  6799999****9888.8************ PP

  == domain 9  score: 12.1 bits;  conditional E-value: 8.9e-05
       EGF_2    5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  +++Cgg   GtC +++  C+C++g++G +C
  EFC39457.1 3258 SSACGGstKGTCTAPN-SCSCKTGWTGSDC 3286
                  688**********999.7************ PP

  == domain 10  score: 9.1 bits;  conditional E-value: 0.00073
       EGF_2    1 Csas..deiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  C ++   ++Cgg   GtC  +   C+C++g++G +C
  EFC39457.1 3291 CFSNtgTSACGGssKGTCTGPD-TCQCQTGWTGSDC 3325
                  777778889**********787.9************ PP

  == domain 11  score: 12.2 bits;  conditional E-value: 8.3e-05
       EGF_2    5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  +++Cgg   GtC +++  C+C+sg++G +C
  EFC39457.1 3336 SSACGGstKGTCTAPN-TCSCQSGWSGSDC 3364
                  789**********999.9************ PP

  == domain 12  score: 17.5 bits;  conditional E-value: 1.8e-06
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C+ +   C+g+G+C +++  C+C+sg++G +C
  EFC39457.1 3369 CPGN---CNGRGSCSAPN-SCSCNSGWTGSDC 3396
                  8877...********999.7************ PP

  == domain 13  score: 12.8 bits;  conditional E-value: 5.2e-05
       EGF_2    5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32  
                  +++Cgg   GtC +++  C+C+sg++G +C
  EFC39457.1 3407 SSACGGstKGTCTAPN-SCSCNSGWSGSDC 3435
                  789**********999.7************ PP

  == domain 14  score: 13.6 bits;  conditional E-value: 2.9e-05
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cs +   Cg +G+C ++ G C+C+sg++G+tC
  EFC39457.1 3440 CSGG---CG-NGVCSSP-GSCSCNSGWSGATC 3466
                  7766...86.7***955.58************ PP

  == domain 15  score: 10.0 bits;  conditional E-value: 0.00039
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cs +   Cg +G+C ++ G C+C+sg++G++C
  EFC39457.1 3477 CSGG---CG-NGYCSSP-GSCSCNSGWSGASC 3503
                  5555...76.7***955.58************ PP

  == domain 16  score: 11.7 bits;  conditional E-value: 0.00011
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cs +   Cg +G+C +  G C+C+sg++G tC
  EFC39457.1 3508 CSGG---CG-NGYCSS-PGTCSCNSGWSGTTC 3534
                  7777...97.7***94.46************* PP

  == domain 17  score: 12.8 bits;  conditional E-value: 5.3e-05
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cs +   Cg +G C +  G+C C+sg++G tC
  EFC39457.1 3539 CSGG---CG-NGFCSA-PGKCTCNSGWSGTTC 3565
                  7776...87.7***94.56************* PP

  == domain 18  score: 16.2 bits;  conditional E-value: 4.5e-06
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cs++   Cg +G+C ++ G C+C+sg++G+tC
  EFC39457.1 3570 CSSG---CG-NGVCSSP-GSCSCNSGWSGATC 3596
                  9988...*7.6***955.58************ PP

  == domain 19  score: 18.2 bits;  conditional E-value: 1.1e-06
       EGF_2    1 Csas.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C ++ +++C+g+G+Cv ++  C+C+sg++G+ C
  EFC39457.1 3596 CTTPvCSTCNGRGSCVGPE-SCSCNSGWSGNLC 3627
                  8899999*********999.6***********9 PP

  == domain 20  score: 21.7 bits;  conditional E-value: 8.3e-08
       EGF_2    1 Csas.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C+++ +++C+g+GtCv ++  C+C+sg++G+ C
  EFC39457.1 3627 CQTPvCSTCNGRGTCVGPE-SCSCSSGWTGNLC 3658
                  999*************999.6***********9 PP

  == domain 21  score: 21.1 bits;  conditional E-value: 1.3e-07
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C ++   C+ghGtC  ++  C+C+sg++G+ C
  EFC39457.1 3663 CTNN---CNGHGTCTGPN-TCSCNSGWSGAAC 3690
                  7665...********888.9***********9 PP

  == domain 22  score: 5.2 bits;  conditional E-value: 0.013
       EGF_2    8 CgghGtCvnqcGqCdCdsgyq.GktC 32  
                   +g+G Cv   G C+C   y+ G++C
  EFC39457.1 3709 SWGQGRCV--SGACVCIGPYYcGAQC 3732
                  589*****..******666666***9 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.4   0.2   8.3e-26   1.9e-22       1     117 [.    2580    2693 ..    2580    2705 .. 0.94

  Alignments for each domain:
  == domain 1  score: 80.4 bits;  conditional E-value: 8.3e-26
                  EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHG CS
         VWA    1 DivfvlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssa 97  
                  D+vf++DgS s+++ n+ + k+f +++ ++l+vgp  tr+g+vq+ss++++e +ln+ +s +++ + ++n+ ++ + t+    ++++a+e + ++ +
  EFC39457.1 2580 DVVFIVDGSYSISDANWVSLKSFFSNITQSLNVGPSATRIGIVQYSSDATVELDLNSGTSSNAIVNRISNIAQKKSATA-SIYGIDKAVELMVSQGR 2675
                  9**********************************************************************99999999.667*******9999999 PP

                  TSSTTSEEEEEEEESS--CS CS
         VWA   98 gaRenakkviilltdGksnd 117 
                  +  +  +k++i +tdG+sn+
  EFC39457.1 2676 S--DVPNKLFIHVTDGQSNM 2693
                  9..45599**********98 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.7   0.3   1.6e-14   3.6e-11       1     107 []    2581    2690 ..    2581    2690 .. 0.90

  Alignments for each domain:
  == domain 1  score: 43.7 bits;  conditional E-value: 1.6e-14
       VWA_2    1 lvfvlDtSgSmrngdygptrleaakdaveallksl...p.gdrvglvtfsdgpevliplt..kdkakilnalrnleakgggtnlaaaLqlarkal.k 90  
                  +vf++D+S S+++      ++  +k++ +++ +sl   p  +r+g+v++s++++v+++l+  ++ ++i n++ n+ +k+ +t    ++++a +++ +
  EFC39457.1 2581 VVFIVDGSYSISDA-----NWVSLKSFFSNITQSLnvgPsATRIGIVQYSSDATVELDLNsgTSSNAIVNRISNIAQKKSATASIYGIDKAVELMvS 2672
                  79***********9.....8*************999996588*****************86789****************************97644 PP

       VWA_2   91 krr.kgekrvivlitDge 107 
                  ++r    ++  +++tDg+
  EFC39457.1 2673 QGRsDVPNKLFIHVTDGQ 2690
                  4444677888899***96 PP

>> DUF2712  Protein of unknown function (DUF2712)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.2       0.6   1.3e+03      44      83 ..     816     855 ..     809     859 .. 0.85
   2 ?    9.0   0.1     0.001       2.3      59     112 ..    2024    2079 ..    2014    2082 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.6
     DUF2712  44 EGkgsvatywlektGllkikvskthdvkqgsgehkYsAys 83 
                 +Gk s+at +++ t  + +   ++++v+ ++ +  Y+  s
  EFC39457.1 816 NGKSSTATVYVNVTNFSPVANEDSYNVHWNAEQQEYEILS 855
                 59999********999999999999999999998887665 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.001
     DUF2712   59 llkikvskthdvkqgsgehkYsAys..easqqnvalaaennnytaksyevsGyWde 112 
                  l++i +s+t ++ +gs  + Y       +s + v+++ +n + + +s+evs  Wd+
  EFC39457.1 2024 LKTITYSDTGSLTTGSDSFSYTITDgvATSSAIVSITFTNTEPSVESFEVSVKWDQ 2079
                  55679****************965511567889**********************7 PP

>> DUF2808  Protein of unknown function (DUF2808)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.0   0.00071       1.6      64     120 ..    1184    1242 ..    1132    1252 .. 0.66
   2 ?   -3.7   0.1       4.6     1e+04      54     110 ..    1644    1699 ..    1635    1700 .. 0.69
   3 ?   -3.2   0.1       3.5   7.8e+03      13      61 ..    1928    1974 ..    1921    2005 .. 0.54
   4 ?   -0.1   0.2      0.37   8.2e+02      43      93 ..    2174    2225 ..    2146    2228 .. 0.70

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00071
     DUF2808   64 afvgttrnkgeklpleevv...wdkenrtieitfdePippgktvtvvlknvrNPrfgGtY 120 
                  + + +++ +++++++e +     d  + +++++ + Pi p+kt++v ++++ N + + +Y
  EFC39457.1 1184 VSN-DKNLGESTFDIEFTDgylTDTATYRVQVYNNIPIVPQKTIEVHWSKYLNDQEDTIY 1242
                  222.233445555553333568999****************************9988777 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 4.6
     DUF2808   54 dikfdlkkveafvgt.....trnkgeklpleevvwdkenrtieitfdePippgktvtvvlkn 110 
                   ++f ++ ++ f+gt     + n+g+k++l      +   ti+i+ ++P +  k +++ +kn
  EFC39457.1 1644 SVTFTPNVTSGFIGTttfyyRINDGNKVSL------PTPVTITINNNPPTSHTKVLNIMWKN 1699
                  566777777777777555555555655555......45568999999999999999999887 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 3.5
     DUF2808   13 alttgksvnrwgarYyltievpkdagealakltisqpdfvedikfdlkk 61  
                   + t+++v     +  ++++v++ a++  ++++is+ +   + k   ++
  EFC39457.1 1928 SHVTFSPVAFKAFTTSFKFTVSDGAQQVEKQFDISITNT--NPKAVDDS 1974
                  555555555555677888888888866667888888874..33333333 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.37
     DUF2808   43 kltisqpdfvedikfdlkkveafvgttrnkgeklpleevv.wdkenrtieit 93  
                   ++isq +++++ ++  +  ++  ++++++g+++++ +v+  d++n + +++
  EFC39457.1 2174 DISISQVRNYNNPQISIDGYSILSQSSDSNGDSITITKVKlYDNQNIETSVV 2225
                  5778887766777777778888887788888888886666767666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (3743 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       842  (0.046963); expected 358.6 (0.02)
Passed bias filter:                      342  (0.0190752); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 1.46u 0.35s 00:00:01.81 Elapsed: 00:00:00.56
# Mc/sec: 20272.02
//
Query:       EFC39458.1  [L=649]
Description: LRR_RI domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      2e-16   58.5  61.1     0.0022   17.9   0.9   15.3 18  LRR_6       Leucine Rich repeat
    4.5e-11   42.8  71.2    6.9e-06   26.3   2.0   11.3 13  LRR_4       Leucine Rich repeats (2 copies)
    0.00011   21.9  55.9     0.0029   17.3   3.4    9.5 10  LRR_8       Leucine rich repeat
  ------ inclusion threshold ------
      0.067   13.9   7.1          2    9.2   0.2    6.6  6  LRR_2       Leucine Rich Repeat
      0.078   12.9   0.5       0.23   11.4   0.1    2.0  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.1   0.0   2.1e-05     0.076       4      24 .]      87     107 ..      84     107 .. 0.92
   2 !   10.6   0.2   0.00013      0.47       3      23 ..     113     133 ..     111     134 .. 0.89
   3 !    6.1   0.1    0.0037        13       4      24 .]     142     162 ..     141     162 .. 0.91
   4 !    6.4   0.1     0.003        11       4      15 ..     170     181 ..     167     182 .. 0.89
   5 !    7.9   0.3   0.00097       3.5       3      15 ..     195     207 ..     193     208 .. 0.90
   6 ?    2.2   0.1     0.067   2.4e+02       4      18 ..     223     237 ..     222     243 .. 0.81
   7 ?   -2.7   0.3       2.5     9e+03       3      10 ..     247     254 ..     245     255 .. 0.82
   8 ?    0.4   0.0      0.25   9.1e+02       3      11 ..     272     280 ..     270     281 .. 0.83
   9 ?   -2.1   0.0       1.5   5.6e+03       2      15 ..     294     307 ..     293     308 .. 0.80
  10 ?   -1.6   0.1       1.1   3.9e+03       5      14 ..     322     331 ..     319     333 .. 0.82
  11 !    7.1   0.0    0.0017       6.2       3      19 ..     417     433 ..     415     438 .. 0.89
  12 ?   -1.2   0.0      0.83     3e+03       3      15 ..     444     456 ..     442     457 .. 0.87
  13 !   17.9   0.9   6.2e-07    0.0022       3      23 ..     470     490 ..     468     491 .. 0.91
  14 !   10.8   0.1   0.00011      0.41       1      23 [.     495     517 ..     495     518 .. 0.91
  15 ?   -1.1   0.1      0.78   2.8e+03       2      11 ..     523     532 ..     522     535 .. 0.79
  16 ?    4.2   0.0     0.015        55      11      23 ..     545     557 ..     543     558 .. 0.80
  17 !    6.4   0.5     0.003        11       3      24 .]     563     584 ..     561     584 .. 0.88
  18 ?   -2.6   0.0       2.3   8.1e+03       5      20 ..     618     633 ..     617     635 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.1e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  L++L+Ls+N++g  Ga+ +a
  EFC39458.1  87 RLESLNLSFNNFGSYGAKLIA 107
                 59***************9997 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00013
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++L+eL L+g+ I +eG+  L
  EFC39458.1 113 MNLRELILNGCTIHGEGLDYL 133
                 79***************9765 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0037
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt L L+ ++++D+ +++La
  EFC39458.1 142 KLTGLGLARCCLTDKAIQKLA 162
                 7899************99997 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.003
       LRR_6   4 hLteLdLsgNdI 15 
                 +L++LdL +N+I
  EFC39458.1 170 NLKYLDLEYNHI 181
                 8**********9 PP

  == domain 5  score: 7.9 bits;  conditional E-value: 0.00097
       LRR_6   3 thLteLdLsgNdI 15 
                 ++L+eL++s++++
  EFC39458.1 195 CNLKELNVSHCGL 207
                 89*********97 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.067
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +L++L+Ls+  I De
  EFC39458.1 223 SLEALNLSFTAILDE 237
                 79*******988665 PP

  == domain 7  score: -2.7 bits;  conditional E-value: 2.5
       LRR_6   3 thLteLdL 10 
                  +L++L+L
  EFC39458.1 247 KKLKTLHL 254
                 589***98 PP

  == domain 8  score: 0.4 bits;  conditional E-value: 0.25
       LRR_6   3 thLteLdLs 11 
                 + Lt+Ld+s
  EFC39458.1 272 PQLTYLDIS 280
                 679*****9 PP

  == domain 9  score: -2.1 bits;  conditional E-value: 1.5
       LRR_6   2 nthLteLdLsgNdI 15 
                 + +L++L +  + +
  EFC39458.1 294 CEKLKTLIMDRCRL 307
                 789****9988865 PP

  == domain 10  score: -1.6 bits;  conditional E-value: 1.1
       LRR_6   5 LteLdLsgNd 14 
                 +++L+L++N 
  EFC39458.1 322 IETLSLMDNV 331
                 689*****96 PP

  == domain 11  score: 7.1 bits;  conditional E-value: 0.0017
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                 +++t  dL +N++gDeG
  EFC39458.1 417 RNVTIIDLYDNELGDEG 433
                 7899************9 PP

  == domain 12  score: -1.2 bits;  conditional E-value: 0.83
       LRR_6   3 thLteLdLsgNdI 15 
                 ++L++L L +N I
  EFC39458.1 444 HNLRKLLLGYNAI 456
                 79****9****98 PP

  == domain 13  score: 17.9 bits;  conditional E-value: 6.2e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt+LdL++N +gD G++ L
  EFC39458.1 470 KSLTHLDLKYNLLGDNGLIQL 490
                 68****************998 PP

  == domain 14  score: 10.8 bits;  conditional E-value: 0.00011
       LRR_6   1 snthLteLdLsgNdIgDeGaeaL 23 
                 + ++L+ LdL  N+I+ eG++ L
  EFC39458.1 495 HLSNLRILDLEINGITKEGIKYL 517
                 5789***************9987 PP

  == domain 15  score: -1.1 bits;  conditional E-value: 0.78
       LRR_6   2 nthLteLdLs 11 
                  ++L +L+L 
  EFC39458.1 523 MSNLNSLNLD 532
                 6899999995 PP

  == domain 16  score: 4.2 bits;  conditional E-value: 0.015
       LRR_6  11 sgNdIgDeGaeaL 23 
                 + N+IgDeG e L
  EFC39458.1 545 QQNKIGDEGFEML 557
                 67*******7765 PP

  == domain 17  score: 6.4 bits;  conditional E-value: 0.003
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L  L +s+N++g+e a+ La
  EFC39458.1 563 NNLLDLCVSYNELGNESAKVLA 584
                 6888899***********9997 PP

  == domain 18  score: -2.6 bits;  conditional E-value: 2.3
       LRR_6   5 LteLdLsgNdIgDeGa 20 
                 L +L + + +I+ eG+
  EFC39458.1 618 LHTLRVLYSEISPEGI 633
                 6677777778888886 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.9   0.00082         3      14      34 ..      77      97 ..      67     102 .. 0.65
   2 !    8.9   3.4   0.00056         2       2      33 ..      87     123 ..      86     155 .. 0.88
   3 !   10.9   1.5   0.00014      0.49       2      39 ..     142     184 ..     141     194 .. 0.66
   4 !   14.5   2.4     1e-05     0.037       2      33 ..     170     205 ..     169     215 .. 0.87
   5 !    8.0   0.9    0.0011       4.1       2      32 ..     223     256 ..     222     265 .. 0.78
   6 !    9.5   0.2   0.00038       1.4      19      42 ..     268     291 ..     259     293 .. 0.75
   7 !    5.3   0.1    0.0081        29       2      33 ..     296     330 ..     295     335 .. 0.87
   8 ?   -2.7   0.1       2.7   9.5e+03       7      19 ..     371     384 ..     371     394 .. 0.73
   9 ?    1.2   0.2      0.16   5.7e+02       2      17 ..     418     433 ..     409     440 .. 0.68
  10 !   26.3   2.0   1.9e-09   6.9e-06       2      38 ..     445     484 ..     444     490 .. 0.87
  11 !   17.7   1.8   9.8e-07    0.0035       1      37 [.     470     510 ..     470     515 .. 0.83
  12 !    8.2   1.0   0.00099       3.6       2      31 ..     498     532 ..     497     535 .. 0.82
  13 ?    2.5   1.2     0.059   2.1e+02       9      35 ..     545     574 ..     544     584 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00082
                -E-S-.HH.H.-TT--EEE-.-S- CS
       LRR_4 14 tdipl.le.k.lpnLkeLdLsgNn 34
                      l+ + l  L++L+Ls+Nn
  EFC39458.1 77 E---DlLScQyLERLESLNLSFNN 97
                2...2433544*********9997 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00056
                 S--EEE--SS---E-S-.HH...H.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl.le...k.lpnLkeLdLsgN 33 
                 +Le+L+Ls N+  + +  l    k l nL+eL L+g+
  EFC39458.1  87 RLESLNLSFNNFGSYGAkLIaesKyLMNLRELILNGC 123
                 79************99993346777*******99998 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 0.00014
                 S--EEE--SS---E-S-..HH....H-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..le....klpnLkeLdLsgNnlitdl 39 
                 +L+ L L+ ++ltd     l+    +l nLk+LdL  N  i+ +
  EFC39458.1 142 KLTGLGLARCCLTDKAIqkLAnnksNLENLKYLDLEYN-HIEMI 184
                 67777788777775222443356756*********777.55444 PP

  == domain 4  score: 14.5 bits;  conditional E-value: 1e-05
                 S--EEE--SS---E-S-...HHH-TT.--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpn.LkeLdLsgN 33 
                 nL++LdL  N++  i++   +++lp  LkeL++s++
  EFC39458.1 170 NLKYLDLEYNHIEMIEFtnlIRNLPCnLKELNVSHC 205
                 9****************8865598888******998 PP

  == domain 5  score: 8.0 bits;  conditional E-value: 0.0011
                 S--EEE--SS---E-S-...HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsg 32 
                 +Le L+Ls + + d  l   ++kl++Lk+L+L +
  EFC39458.1 223 SLEALNLSFTAILDEHLevlCNKLKKLKTLHLVR 256
                 6999*****99998444554447********955 PP

  == domain 6  score: 9.5 bits;  conditional E-value: 0.00038
                 HHH-TT--EEE-.-S-----GGGG CS
       LRR_4  19 leklpnLkeLdLsgNnlitdldeL 42 
                 l klp+L++Ld+s+ n  + l++L
  EFC39458.1 268 LDKLPQLTYLDISNVNATSILSDL 291
                 456*********997676666666 PP

  == domain 7  score: 5.3 bits;  conditional E-value: 0.0081
                 S--EEE--SS---E-S-HH..H.-TT--EEE-.-S CS
       LRR_4   2 nLevLdLsnNqltdiplle..k.lpnLkeLdLsgN 33 
                 +L++L    ++l++++ ++  + l   ++L+L +N
  EFC39458.1 296 KLKTLIMDRCRLKTFDQFQdsNyLSGIETLSLMDN 330
                 89***************888866********9555 PP

  == domain 8  score: -2.7 bits;  conditional E-value: 2.7
                 E--SS---E-S-.H CS
       LRR_4   7 dLsnNqltdipl.l 19 
                 +L +N++++i++ +
  EFC39458.1 371 NLVDNKVSKINPkF 384
                 56789999888754 PP

  == domain 9  score: 1.2 bits;  conditional E-value: 0.16
                 S--EEE--SS---E-S CS
       LRR_4   2 nLevLdLsnNqltdip 17 
                 n +++dL +N l d +
  EFC39458.1 418 NVTIIDLYDNELGDEG 433
                 6677777777777644 PP

  == domain 10  score: 26.3 bits;  conditional E-value: 1.9e-09
                 S--EEE--SS---E-S-HH....H-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdiplle....klpnLkeLdLsgNnlitd 38 
                 nL++L L+ N +++ip++e    +l++L++LdL  N l++d
  EFC39458.1 445 NLRKLLLGYNAIKEIPSPEechsNLKSLTHLDLKYN-LLGD 484
                 9****************8888977*********556.8776 PP

  == domain 11  score: 17.7 bits;  conditional E-value: 9.8e-07
                 SS--EEE--SS---E-S-HH.....H-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdiplle.....klpnLkeLdLsgNnlit 37 
                 ++L++LdL  N l d +l++      l nL+ LdL + n it
  EFC39458.1 470 KSLTHLDLKYNLLGDNGLIQlvknpHLSNLRILDL-EINGIT 510
                 68****************66667877999******.655665 PP

  == domain 12  score: 8.2 bits;  conditional E-value: 0.00099
                 S--EEE--SS---E-S-..HH...H-TT--EEE-. CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLs 31 
                 nL++LdL  N +t+ +   l     + nL +L+L 
  EFC39458.1 498 NLRILDLEINGITKEGIkyLVespHMSNLNSLNLD 532
                 9*******88***988887335666********95 PP

  == domain 13  score: 2.5 bits;  conditional E-value: 0.059
                 -SS---E-S-...HHH.-TT--EEE-.-S-- CS
       LRR_4   9 snNqltdipl...lek.lpnLkeLdLsgNnl 35 
                 ++N++ d ++   l++ l nL  L +s N  
  EFC39458.1 545 QQNKIGDEGFemlLNSnLNNLLDLCVSYN-E 574
                 67999999999988855*******88888.3 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.5    0.0041        15      45      60 ..      82      97 ..      73      98 .. 0.77
   2 !    5.8   1.5    0.0032        11      23      45 ..      84     106 ..      81     125 .. 0.56
   3 !   11.7   2.7   4.7e-05      0.17      22      61 .]     166     207 ..     153     207 .. 0.80
   4 !    8.6   1.5   0.00042       1.5       3      58 ..     224     281 ..     222     284 .. 0.86
   5 !   13.4   0.2   1.4e-05     0.049       2      61 .]     248     307 ..     247     307 .. 0.82
   6 !    5.1   0.1    0.0052        19       2      37 ..     296     332 ..     295     335 .. 0.92
   7 ?   -0.7   0.0      0.35   1.2e+03      23      37 ..     415     429 ..     411     437 .. 0.78
   8 !   17.3   3.4   8.1e-07    0.0029      24      61 .]     443     482 ..     417     482 .. 0.76
   9 ?    2.0   2.0     0.049   1.8e+02      24      39 ..     496     511 ..     493     533 .. 0.51
  10 ?   -2.1   2.2      0.92   3.3e+03      22      38 ..     560     576 ..     557     586 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0041
                GTT--S-.EEE--SS- CS
       LRR_8 45 fsgLpsLrsLdLsgNr 60
                ++ L++L+sL+Ls N+
  EFC39458.1 82 CQYLERLESLNLSFNN 97
                5667888888888887 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0032
                 T-TT--EEE--SS---GGGGGGG CS
       LRR_8  23 glsnLkvLdLsnNllttlspgaf 45 
                  l++L++L+Ls N+  +  ++ +
  EFC39458.1  84 YLERLESLNLSFNNFGSYGAKLI 106
                 46677777777777666665544 PP

  == domain 3  score: 11.7 bits;  conditional E-value: 4.7e-05
                 TT-TT--EEE--SS---GGG.GGGGTT--.S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttls.pgafsgLp.sLrsLdLsgNrL 61 
                 ++l+nLk+LdL +N ++ ++  + +++Lp +L++L++s++ L
  EFC39458.1 166 SNLENLKYLDLEYNHIEMIEfTNLIRNLPcNLKELNVSHCGL 207
                 479***********9999864667777776788888888865 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.00042
                 -SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G.GGGGGGTT--S-.EEE--S CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsg 58 
                 L+ L+Ls++ + + + e+  + l++Lk+L+L + + +  + + +++ Lp+L++Ld+s+
  EFC39458.1 224 LEALNLSFTAILDEHLEVLCNkLKKLKTLHLVRVSVDGsFKKIVLDKLPQLTYLDISN 281
                 8889999999777777777777***********9999889999************998 PP

  == domain 5  score: 13.4 bits;  conditional E-value: 1.4e-05
                 T-SEEE-TTS--S.EE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrlt.slddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L++L+L + +   s ++ +  +l++L++Ld+sn + t++    ++++++L+ L ++++rL
  EFC39458.1 248 KLKTLHLVRVSVDgSFKKIVLDKLPQLTYLDISNVNATSI-LSDLRSCEKLKTLIMDRCRL 307
                 68999999999551455555666***********999998.58**************9987 PP

  == domain 6  score: 5.1 bits;  conditional E-value: 0.0052
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNll 37 
                 +L++L+ ++ rl+  d+ + ++ ls+ ++L+L +N  
  EFC39458.1 296 KLKTLIMDRCRLKTFDQFQDSNyLSGIETLSLMDNVF 332
                 79******************************99965 PP

  == domain 7  score: -0.7 bits;  conditional E-value: 0.35
                 T-TT--EEE--SS-- CS
       LRR_8  23 glsnLkvLdLsnNll 37 
                  l+n++++dL +N+l
  EFC39458.1 415 YLRNVTIIDLYDNEL 429
                 477888888888876 PP

  == domain 8  score: 17.3 bits;  conditional E-value: 8.1e-07
                 -TT--EEE--SS---GG..GGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttl..spgafsgLpsLrsLdLsgNrL 61 
                 ++nL+ L L++N ++ +   +++ s+L+sL++LdL +N L
  EFC39458.1 443 MHNLRKLLLGYNAIKEIpsPEECHSNLKSLTHLDLKYNLL 482
                 8899999999999999732468888999999999999976 PP

  == domain 9  score: 2.0 bits;  conditional E-value: 0.049
                 -TT--EEE--SS---G CS
       LRR_8  24 lsnLkvLdLsnNlltt 39 
                 lsnL++LdL  N +t 
  EFC39458.1 496 LSNLRILDLEINGITK 511
                 5666666666665543 PP

  == domain 10  score: -2.1 bits;  conditional E-value: 0.92
                 TT-TT--EEE--SS--- CS
       LRR_8  22 kglsnLkvLdLsnNllt 38 
                 ++l+nL  L  s+N+l 
  EFC39458.1 560 SNLNNLLDLCVSYNELG 576
                 57999999999999885 PP

>> LRR_2  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.76   2.7e+03       2      13 ..      88     100 ..      87     105 .. 0.81
   2 ?   -0.9   0.0      0.85     3e+03       1      12 [.     170     181 ..     170     194 .. 0.70
   3 ?    9.2   0.2   0.00056         2       1      20 [.     248     265 ..     248     267 .. 0.77
   4 ?    0.2   0.0       0.4   1.4e+03       1      12 [.     296     307 ..     296     314 .. 0.77
   5 ?   -1.4   0.0       1.2   4.4e+03       4      12 ..     324     332 ..     323     337 .. 0.80
   6 ?   -1.6   0.0       1.4   5.2e+03      14      22 ..     550     558 ..     546     559 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.76
       LRR_2   2 LKtLhLdsVrf.s 13 
                 L +L+L+ + f s
  EFC39458.1  88 LESLNLSFNNFgS 100
                 899*****99954 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.85
       LRR_2   1 sLKtLhLdsVrf 12 
                 +LK L L+++ +
  EFC39458.1 170 NLKYLDLEYNHI 181
                 599999998866 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00056
       LRR_2   1 sLKtLhLdsVrfsdedslek 20 
                 +LKtLhL +V  ++   + k
  EFC39458.1 248 KLKTLHLVRVSVDGS--FKK 265
                 6*********95544..766 PP

  == domain 4  score: 0.2 bits;  conditional E-value: 0.4
       LRR_2   1 sLKtLhLdsVrf 12 
                 +LKtL  d++r 
  EFC39458.1 296 KLKTLIMDRCRL 307
                 69***9999987 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 1.2
       LRR_2   4 tLhLdsVrf 12 
                 tL+L +++f
  EFC39458.1 324 TLSLMDNVF 332
                 9*****997 PP

  == domain 6  score: -1.6 bits;  conditional E-value: 1.4
       LRR_2  14 dedslekLL 22 
                 +++++e+LL
  EFC39458.1 550 GDEGFEMLL 558
                 5669****8 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1   6.5e-05      0.23       6      36 ..       6      37 ..       6      41 .. 0.87
   2 ?   -3.6   0.0         3   1.1e+04      21      36 ..     148     163 ..     137     165 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 6.5e-05
  F-box-like  6 dEiLlqIFsyLppsdLlr.lalVCrrWrrval 36
                d+ L +I+ ++p  dLl  + lV++++++ a+
  EFC39458.1  6 DDCLFHILTFVPSLDLLKnCLLVSKQFQENAR 37
                678*******988898888********99875 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 3
  F-box-like  21 LlrlalVCrrWrrval 36 
                 L+r++l+ +  + +a+
  EFC39458.1 148 LARCCLTDKAIQKLAN 163
                 8899999888877775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (649 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 3644.82
//
Query:       EFC39459.1  [L=137]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.6e-07   29.6   1.4    7.6e-07   29.4   0.2    1.7  2  PTH2             Peptidyl-tRNA hydrolase PTH2
     0.0022   17.2  14.1     0.0026   17.0  14.1    1.0  1  Astro_capsid_p   Turkey astrovirus capsid protein
     0.0024   17.2   0.2     0.0026   17.1   0.2    1.1  1  Zip              ZIP Zinc transporter
  ------ inclusion threshold ------
      0.051   12.8   0.6      0.055   12.7   0.6    1.1  1  Med13_C          Mediator complex subunit 13 C-terminal domai
       0.11   11.6   8.5       0.12   11.5   8.5    1.1  1  Pes-10           Pes-10
       0.17   11.6  11.1        0.2   11.3  11.1    1.1  1  Cwf_Cwc_15       Cwf15/Cwc15 cell cycle control protein
       0.27   11.5  14.2       0.33   11.2  14.2    1.1  1  RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc3
       0.29   11.2   6.6       0.38   10.8   6.6    1.2  1  RXT2_N           RXT2-like, N-terminal
       0.35    8.8   5.5       0.46    8.4   5.5    1.1  1  Dicty_REP        Dictyostelium (Slime Mold) REP protein
       0.58    8.2  13.2       0.64    8.0  13.2    1.1  1  DNA_pol_phi      DNA polymerase phi
       0.66    9.3  15.3       0.38   10.0  10.8    2.0  2  NOA36            NOA36 protein
        0.7    9.2   3.4       0.87    8.9   3.4    1.1  1  DUF4820          Domain of unknown function (DUF4820)
        2.7    8.0   7.5          4    7.4   7.5    1.2  1  DUF3439          Domain of unknown function (DUF3439)
        2.9    6.0  11.6        3.2    5.9  11.6    1.0  1  Nop14            Nop14-like family
          3    7.0   6.4        3.5    6.8   6.4    1.1  1  TRAP_alpha       Translocon-associated protein (TRAP), alpha 
        3.4    6.7  15.7          4    6.5  15.7    1.1  1  DUF2457          Protein of unknown function (DUF2457)
        3.6    5.8   8.9        4.2    5.5   8.9    1.1  1  CDC45            CDC45-like protein


Domain annotation for each model (and alignments):
>> PTH2  Peptidyl-tRNA hydrolase PTH2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       2.9     3e+03      95     101 ..      55      61 ..      30      84 .. 0.58
   2 !   29.4   0.2   7.2e-10   7.6e-07       2      26 ..     109     133 ..     108     137 .] 0.92

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2.9
                 EEEEEEE CS
        PTH2  95 TvlaigP 101
                 T     P
  EFC39459.1  55 TTTTTTP 61 
                 3333333 PP

  == domain 2  score: 29.4 bits;  conditional E-value: 7.2e-10
                 EEEEEEESSSSS-HHHHHHHHHHHH CS
        PTH2   2 kmvlvvrkDLkmskGkiaaqcahAa 26 
                 k++l+vr+D++m+kGk++aqc+hA 
  EFC39459.1 109 KLLLLVRTDVNMQKGKMCAQCGHAR 133
                 789********************96 PP

>> Astro_capsid_p  Turkey astrovirus capsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0  14.1   2.4e-06    0.0026     221     295 ..      41     119 ..      21     121 .. 0.67

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 2.4e-06
                     ..XXXX.........XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXX CS
  Astro_capsid_p 221 egederktg...aeeeisdpsdeedeevsdeetdtevesdeDeddevdrfDletsye..SeaeDddvennRvtLlnTliN 295
                     +++ + +++   ++++   ++++ ++++ ++ +++++e+ eDe d+ d+fD+e+s e  S++eDdd   + ++L+ T +N
      EFC39459.1  41 STSTPSNVEpvtTTTTTTTTPEASSTTTIEKKEENDDEDWEDEGDDDDEFDEEESGEdySDEEDDD-PKKLLLLVRTDVN 119
                     4444455552112333333444444666778889999999************99866669999999.5666666666555 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.2   2.4e-06    0.0026      76     171 ..      10     105 ..       1     133 [. 0.87

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 2.4e-06
         Zip  76 plagllvllGflllllveklltmivekksshkektpkkasssssesaakksvsndkveeseekedhvaeadtdadskeelrngkqeksesekeqas 171
                 pl    + +G l + + e ll   +++++  ++ tp++ +  +++  +  + +++++++ e+ke+++ e+++d+  +  + +++++ ++ ++e+ +
  EFC39459.1  10 PLILSSFAVGVLSVKFCEWLLLKRKDEEKIVSTSTPSNVEPVTTTTTTTTTPEASSTTTIEKKEENDDEDWEDEGDDDDEFDEEESGEDYSDEEDD 105
                 6667788999999**************999**************************************************9999999988887654 PP

>> Med13_C  Mediator complex subunit 13 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.6   5.2e-05     0.055     163     225 ..      42     103 ..      16     124 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.2e-05
     Med13_C 163 sstplstPqdsscthilvfptsattqstpttfasedanaedtpedsseeddsdallvdltdet 225
                 +stp ++ +++++t+ ++++++a++++t  + ++ d+++++++ d+++e d + +  d++de 
  EFC39459.1  42 TSTPSNV-EPVTTTTTTTTTPEASSTTTIEKKEENDDEDWEDEGDDDDEFDEEESGEDYSDEE 103
                 2344444.3444444444444444444444444444444444444444445555555544443 PP

>> Pes-10  Pes-10
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   8.5   0.00011      0.12     181     214 ..      64     103 ..      27     119 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00011
      Pes-10 181 e......edseeddddiededeedesssstdsgiesedeE 214
                        +++e+dd+d+ede ++d+++++++sg +  deE
  EFC39459.1  64 SstttieKKEENDDEDWEDEGDDDDEFDEEESGEDYSDEE 103
                 044444244556669******************9998888 PP

>> Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3  11.1   0.00019       0.2      83     150 ..      49     111 ..      26     122 .. 0.41

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00019
                 -------------------------..----------------------------------------- CS
  Cwf_Cwc_15  83 kekkeeeeeeeeeeakrrkeelleeareidaddedseeeeeeeeeesdddsdsdsdddddedetaeLl 150
                 +  +++++++++ ea  ++  ++e+++e d++d ++ e +++  +e d++++ ++ +d+++d+ ++Ll
  EFC39459.1  49 EPVTTTTTTTTTPEASSTT--TIEKKEENDDEDWED-EGDDD--DEFDEEESGEDYSDEEDDDPKKLL 111
                 2222222222233333333..555543333333332.22222..233334444444444455555554 PP

>> RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc31
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2  14.2   0.00032      0.33     170     211 ..      65     105 ..      28     107 .. 0.51

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00032
  RNA_pol_3_Rpc31 170 lleklkelaeeeddeeekkekedeeeee.eeeeddefdddded 211
                         ++ e++ee+dd e+++++ d+++e  eee  ++++d+++d
       EFC39459.1  65 STTTI-EKKEENDD-EDWEDEGDDDDEFdEEESGEDYSDEEDD 105
                      22223.33444444.3454444443333678888888877743 PP

>> RXT2_N  RXT2-like, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   6.6   0.00036      0.38      54      94 ..      59     110 ..      31     116 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00036
      RXT2_N  54 k........kekekeekeeeeedeegdeededdddee...eaeaaeenpykk 94 
                 +        + ++kee+++e+ ++egd++de d++e+    +++++++p k+
  EFC39459.1  59 TtpeassttTIEKKEENDDEDWEDEGDDDDEFDEEESgedYSDEEDDDPKKL 110
                 0333333333444455555566666666666555555765677788888776 PP

>> Dicty_REP  Dictyostelium (Slime Mold) REP protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   5.5   0.00044      0.46     246     316 ..      42     109 ..      30     129 .. 0.52

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00044
   Dicty_REP 246 nsqpskeknkttttttttttttsqartrkrkaidddklsenqakekkknskksdddpqsdfskkssrksgs 316
                 +s ps+ +     ttttttttt++a  +  + +++++  e+ + e  ++ +  ++++++d+s+  +++  +
  EFC39459.1  42 TSTPSNVE---PVTTTTTTTTTPEASSTTTIEKKEENDDEDWEDEGDDDDEFDEEESGEDYSDEEDDDPKK 109
                 23333333...334444444444443333333333444444445555666666667777788777766554 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0  13.2   0.00061      0.64     639     682 ..      70     106 ..      44     124 .. 0.48

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00061
  DNA_pol_phi 639 edededeeddeeeeeeddeededseedddeeesdedeededded 682
                  e+++e++++d e+e++dd+e        deees ed +de+d+d
   EFC39459.1  70 EKKEENDDEDWEDEGDDDDE-------FDEEESGEDYSDEEDDD 106
                  22222222222222222222.......22222222222222222 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0  10.8   0.00036      0.38     263     304 ..      63     104 ..      22     110 .. 0.53
   2 ?    1.7   0.1      0.13   1.4e+02      61      74 ..     120     133 ..     116     136 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00036
       NOA36 263 lasgddeddegdedddddddeedddeeeddedeeeeeeeese 304
                  +s++  ++++++dd+d +de ddd+e d+e++ e+ ++e++
  EFC39459.1  63 ASSTTTIEKKEENDDEDWEDEGDDDDEFDEEESGEDYSDEED 104
                 233333333333344443444444443333333333332222 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.13
       NOA36  61 vqrlpicakcgkvk 74 
                 +q+  +ca+cg+ +
  EFC39459.1 120 MQKGKMCAQCGHAR 133
                 79999******976 PP

>> DUF4820  Domain of unknown function (DUF4820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   3.4   0.00082      0.87     161     223 ..      44     106 ..      16     110 .. 0.53

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00082
     DUF4820 161 ldnsartlterk.sekesaesseskkrnkeerdaeseeessedeeeeetvkellekyanensed 223
                 + ++++ +t+ + + ++ ++ss+++ ++kee+d e+ e++  d+++e   +e  e y +e+ +d
  EFC39459.1  44 TPSNVEPVTTTTtTTTTPEASSTTTIEKKEENDDEDWEDEG-DDDDEFDEEESGEDYSDEEDDD 106
                 33333333333303333333333334444444444444444.3477888888999999886443 PP

>> DUF3439  Domain of unknown function (DUF3439)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   7.5    0.0038         4      42      65 ..      46      69 ..      30      74 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0038
     DUF3439 42 siicpttttttttttttmpttttl 65
                s + p ttttttttt    +ttt+
  EFC39459.1 46 SNVEPVTTTTTTTTTPEASSTTTI 69
                567899999999999988888887 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  11.6     0.003       3.2     357     402 ..      69     105 ..      30     125 .. 0.43

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.003
       Nop14 357 edddlveseseeeeeeeeedeeeeedeeeeeeeeededdlsdlese 402
                 +++         +ee+++ed e+e d+++e +eee+ +d sd+e++
  EFC39459.1  69 IEK---------KEENDDEDWEDEGDDDDEFDEEESGEDYSDEEDD 105
                 111.........1112222222222222222333333333222211 PP

>> TRAP_alpha  Translocon-associated protein (TRAP), alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   6.4    0.0033       3.5      18      68 ..      60     109 ..      40     127 .. 0.55

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0033
  TRAP_alpha  18 ssatkvvaaaaaeedevddelvdveaedeeveeeeeeeeeeeeeeeedeee 68 
                 + +++++++ +++e++ d++ +d   +d+e +eee+  e+ ++ee++d ++
  EFC39459.1  60 TPEASSTTTIEKKEENDDEDWEDEGDDDDEFDEEES-GEDYSDEEDDDPKK 109
                 233333344444444444445564444444444444.44455555555543 PP

>> DUF2457  Protein of unknown function (DUF2457)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  15.7    0.0038         4      52      91 ..      69     108 ..      53     124 .. 0.54

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0038
     DUF2457  52 eeeeeeeddeedeeddddddddeddded.ddeedededdds 91 
                  e++e e+d+ed ed+ dddd+ d++e  +d  de++dd +
  EFC39459.1  69 IEKKE-ENDDEDWEDEGDDDDEFDEEESgEDYSDEEDDDPK 108
                 34433.44444444443433333333332555666664443 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   8.9     0.004       4.2     121     164 ..      64     106 ..      47     121 .. 0.59

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.004
       CDC45 121 eayealeeeeesdeedeeeeeeddddeeeeeeeeedeedeeede 164
                 ++  ++e++ee+d+ed  e+e dddde +eee+ ed +dee+d+
  EFC39459.1  64 SSTTTIEKKEENDDED-WEDEGDDDDEFDEEESGEDYSDEEDDD 106
                 4445555555555433.444445554555555555444444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (137 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1312  (0.0731775); expected 358.6 (0.02)
Passed bias filter:                      671  (0.0374254); expected 358.6 (0.02)
Passed Vit filter:                       122  (0.00680462); expected 17.9 (0.001)
Passed Fwd filter:                        25  (0.00139439); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.58u 0.37s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 796.77
//
Query:       EFC39460.1  [L=240]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-19   68.4   0.1    7.6e-19   67.7   0.1    1.3  1  GST_C_3   Glutathione S-transferase, C-terminal domain
    3.1e-10   40.1   0.0    5.2e-10   39.4   0.0    1.4  1  GST_C     Glutathione S-transferase, C-terminal domain
    7.2e-06   26.3   0.0    1.7e-05   25.0   0.0    1.7  1  GST_N     Glutathione S-transferase, N-terminal domain
    2.8e-05   24.0   0.0      5e-05   23.2   0.0    1.5  1  GST_C_2   Glutathione S-transferase, C-terminal domain
     0.0043   17.4   0.0     0.0098   16.3   0.0    1.6  1  GST_N_3   Glutathione S-transferase, N-terminal domain
  ------ inclusion threshold ------
      0.087   12.6   0.1          8    6.3   0.0    2.4  2  GST_C_6   Glutathione S-transferase, C-terminal domain
       0.14   12.5   0.0       0.46   10.8   0.0    1.9  2  GST_N_2   Glutathione S-transferase, N-terminal domain


Domain annotation for each model (and alignments):
>> GST_C_3  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.7   0.1     3e-22   7.6e-19      17      97 ..     128     218 ..     111     220 .. 0.84

  Alignments for each domain:
  == domain 1  score: 67.7 bits;  conditional E-value: 3e-22
                 HH..HHHHHHHHHHHHCHHHHHHHHHHCHGTSSSSTTS--HHHHHHHHHHHHHHHH.......TCC...CC-HHHHHHHHHHHTSHHHHHHHC CS
     GST_C_3  17 ea..ekkkefleerlpkflkyfekvlkkkgggylvgdklTyADlalfqvldgleea.......eal...kkfpklkalyervearpkikaYle 97 
                 e+  +k + +l+e+lpk l++fe++l+  g++ylvg+k++yAD+alf +ld+++e+       + l   ++ ++lk+l++rv+ar++i+++l+
  EFC39460.1 128 ESieQKIQIILKEKLPKLLQFFERALE-GGKEYLVGGKISYADIALFYALDTYTEVlgsyfenQ-LnsgEELKNLKQLHARVKAREGIQKHLN 218
                 33668888999****************.7777**************************999752.2467999******************996 PP

>> GST_C  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.4   0.0     2e-13   5.2e-10      18      93 .]     129     211 ..     107     211 .. 0.84

  Alignments for each domain:
  == domain 1  score: 39.4 bits;  conditional E-value: 2e-13
                 HHHHHHHHHHHHHHHHHHHHHHHHHH.TSSSSSTTSSCHHHHHHHHHHH.HHHHHTTTTT.....TTTSHHHHHHHHHHHTSH CS
       GST_C  18 ekkeelvdealekvaevlsaleeelk.kqdylvGdkltlADialvpiln.wlqrlglafg.....qekfpnlkawlerimarp 93 
                   +++ + +++ek+ + l+++e  l+ ++ ylvG k+++ADial+ +l+ + + lg  f+      e+ +nlk+ + r+ ar+
  EFC39460.1 129 SIEQKIQIILKEKLPKLLQFFERALEgGKEYLVGGKISYADIALFYALDtYTEVLGSYFEnqlnsGEELKNLKQLHARVKARE 211
                 56677788899**************************************75555566666777777***********999886 PP

>> GST_N  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.0   0.0   6.8e-09   1.7e-05       3      75 ..       6      81 ..       4      82 .. 0.89

  Alignments for each domain:
  == domain 1  score: 25.0 bits;  conditional E-value: 6.8e-09
                EEEESSSTSHTHHHHHHHHHHTT-EEEEEEECSTTTCGGCHHHHHHCTT.....S-SSEEEETTEEEESHHHHHHHHH CS
       GST_N  3 ltlysirgsprahrirlllaakgveyevvpldfeageekspellklnpl.....gkvPaLedngkkltESraIleYia 75
                lt++s rg   ++ ir+ la  gv+y +v++ +    eks+ +++l +        +P  +d+   l++S  I++Y+ 
  EFC39460.1  6 LTYFSSRG--KSELIRIILADCGVDYDEVNVGVWHPTEKSDAFKQLVESktlafDSLPSYQDDQILLVQSSSIVRYLG 81
                79******..********************9987777777777776666666************************96 PP

>> GST_C_2  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.0   1.9e-08     5e-05       7      54 ..     138     187 ..      96     207 .. 0.79

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 1.9e-08
                 HHHHCCHCHHHCTTT---SS..CTTCS--HHHHHHHHHHH.HHHHHHHS- CS
     GST_C_2   7 aleqldaaldaleahLadsp.flfGdqptlaDialapflv.rlraagpgf 54 
                 ++e+l + l ++e+ L+++  +l G+++++aDial+  l  ++++ g +f
  EFC39460.1 138 LKEKLPKLLQFFERALEGGKeYLVGGKISYADIALFYALDtYTEVLGSYF 187
                 577888999999************************99884445555555 PP

>> GST_N_3  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   3.8e-06    0.0098      12      72 ..      17      85 ..       9      93 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.8e-06
                HHHHHHHHHT--EEEE--...-TTTTHHHHHHH-.....TT--SSEEETTS-EEESHHHHHHHHHHHH- CS
     GST_N_3 12 rvrlaLnekglpvevvev...tpgehdeellakn.....plgkvPvLeddgealtdSlaIidyLeelyp 72
                 +r++L  +g+++ +v+v   +p+e+++++++           +P  +dd+  l  S++I++yL ++++
  EFC39460.1 17 LIRIILADCGVDYDEVNVgvwHPTEKSDAFKQLVesktlAFDSLPSYQDDQILLVQSSSIVRYLGKKFG 85
                68*************99944448889999999994444555568********************99986 PP

>> GST_C_6  Glutathione S-transferase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.015        39      41      63 ..     129     151 ..     119     152 .. 0.81
   2 ?    6.3   0.0    0.0031         8      13      62 ..     155     205 ..     151     207 .. 0.71

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.015
     GST_C_6  41 plespelrellk.eypNLvaycer 63 
                  +e++ ++ +lk ++p+L+++ er
  EFC39460.1 129 SIEQK-IQIILKeKLPKLLQFFER 151
                 45555.999*************99 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0031
     GST_C_6  13 gdkkyFfGdkPtslDAlvFGhlaqilytplespelrellk...eypNLvayce 62 
                 g k+y+ G k++ +D ++F +    +++ l+s  +++ l+   e++NL ++  
  EFC39460.1 155 GGKEYLVGGKISYADIALF-YALDTYTEVLGSY-FENQLNsgeELKNLKQLHA 205
                 6799****88*********.6666656667777.6666665556777766655 PP

>> GST_N_2  Glutathione S-transferase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   0.00018      0.46       8      69 ..      18      82 ..      15      83 .. 0.83
   2 ?   -2.4   0.0       2.4   6.1e+03      28      41 ..     188     201 ..     177     225 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00018
                HHHHHHHCT--EEEEEEH...-TTSHHHHHHHHCTTT.....SSSEEE-CTTEEEESHHHHHHHHHH CS
     GST_N_2  8 vlialalkglediisvvvlepkgfekseefprlnprg.....tVPvLwdkdgqvineSseIlrylet 69
                ++i la +g+++    v  + ++ eks+ f++l  +      ++P  +d d+  ++ Ss I+ryl++
  EFC39460.1 18 IRIILADCGVDYDEVNVGVW-HPTEKSDAFKQLVESKtlafdSLPSYQD-DQILLVQSSSIVRYLGK 82
                6999*******998888556.46778999*9999777455567*****8.878999*********86 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.4
                 .-TTSHHHHHHHHC CS
     GST_N_2  28 pkgfekseefprln 41 
                 +++ + +ee+++l+
  EFC39460.1 188 ENQLNSGEELKNLK 201
                 56666666665554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (240 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       542  (0.0302304); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.54u 0.31s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 1452.70
//
Query:       EFC39461.1  [L=622]
Description: TPR domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-16   58.3   5.2    4.7e-08   32.5   0.0    4.5  4  TPR_1     Tetratricopeptide repeat
    3.9e-15   54.7  10.0    1.8e-06   27.6   0.0    4.8  4  TPR_2     Tetratricopeptide repeat
      2e-10   40.0   8.2    0.00044   20.2   0.1    5.2  5  TPR_8     Tetratricopeptide repeat
      1e-08   35.4   6.3    5.1e-05   23.5   0.4    3.3  4  TPR_12    Tetratricopeptide repeat
      2e-06   28.1   0.2        0.2   12.4   0.0    4.0  3  TPR_6     Tetratricopeptide repeat
     0.0014   19.2   0.0        1.6    9.5   0.0    2.5  2  TPR_16    Tetratricopeptide repeat
     0.0023   18.0   0.0      0.021   15.0   0.0    2.3  2  TPR_9     Tetratricopeptide repeat
     0.0024   17.8   1.4        2.9    8.1   0.1    3.6  3  TPR_7     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.036   14.3   3.2          2    8.7   0.5    2.7  2  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
      0.055   13.9   3.1          2    9.0   0.1    3.9  3  TPR_17    Tetratricopeptide repeat
       0.11   12.4   2.8        0.1   12.5   0.5    2.2  3  F-box     F-box domain


Domain annotation for each model (and alignments):
>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.3   1.6e-07   0.00027       3      30 ..     143     170 ..     141     173 .. 0.92
   2 ?    3.7   0.0     0.036        59      21      30 ..     279     288 ..     275     292 .. 0.80
   3 !   32.5   0.0   2.9e-11   4.7e-08       3      31 ..     300     328 ..     299     329 .. 0.94
   4 ?   -0.5   0.1      0.78   1.3e+03       6      18 ..     340     352 ..     336     361 .. 0.63

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.6e-07
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALel 30 
                 a y lG++y+ +g+++eA  +++k +e+
  EFC39461.1 143 AEYLLGMCYHGNGDFKEAAIHFQKSIEH 170
                 779***********************97 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.036
                 HHHHHHHHHH CS
       TPR_1  21 leyyekALel 30 
                 +ey+++A+el
  EFC39461.1 279 VEYFNRAIEL 288
                 79*******9 PP

  == domain 3  score: 32.5 bits;  conditional E-value: 2.9e-11
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHHS CS
       TPR_1   3 alynlGnayfklgkydeAleyyekALeln 31 
                 ++yn+G++y++lg+++ A+e++ k ++l 
  EFC39461.1 300 SYYNRGLCYYYLGELETAIEDFTKSISLM 328
                 6*************************985 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 0.78
                 HHHHHHHHTT-HH CS
       TPR_1   6 nlGnayfklgkyd 18 
                  ++++y +lg+ +
  EFC39461.1 340 MRAATYGRLGMIK 352
                 5666666666544 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.25   4.1e+02       2      31 ..      90     119 ..      89     121 .. 0.83
   2 !   19.7   0.1   3.7e-07    0.0006       5      30 ..     145     170 ..     142     172 .. 0.93
   3 !    8.9   0.3    0.0011       1.8       3      30 ..     261     288 ..     259     292 .. 0.92
   4 !   27.6   0.0   1.1e-09   1.8e-06       4      32 ..     301     329 ..     299     331 .. 0.95

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.25
       TPR_2   2 ealynlGlayyklgdyeeAleafekAleld 31 
                 ++l ++  a +++ dy  A++++ +Al+l 
  EFC39461.1  90 KLLIQRCIARLEQPDYGLAKDDMLEALSLM 119
                 6677777888888899***********985 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 3.7e-07
       TPR_2   5 ynlGlayyklgdyeeAleafekAlel 30 
                 y lG++y  +gd++eA+ +f+k++e+
  EFC39461.1 145 YLLGMCYHGNGDFKEAAIHFQKSIEH 170
                 89*********************986 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0011
       TPR_2   3 alynlGlayyklgdyeeAleafekAlel 30 
                 ++ + G +yy    y+  +e+f++A+el
  EFC39461.1 261 LYIRAGVSYYSGTYYANGVEYFNRAIEL 288
                 68999**********************9 PP

  == domain 4  score: 27.6 bits;  conditional E-value: 1.1e-09
       TPR_2   4 lynlGlayyklgdyeeAleafekAleldP 32 
                 +yn+Gl+yy+lg++e A+e+f k+++l P
  EFC39461.1 301 YYNRGLCYYYLGELETAIEDFTKSISLMP 329
                 9**************************99 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       2.3   3.8e+03      16      30 ..     104     118 ..     102     118 .. 0.91
   2 !   12.9   0.1   6.1e-05     0.099       5      29 ..     145     169 ..     145     169 .. 0.96
   3 !    6.2   0.2    0.0084        14       4      30 ..     262     288 ..     260     291 .. 0.91
   4 !   20.2   0.1   2.7e-07   0.00044       3      30 ..     300     327 ..     298     329 .. 0.94
   5 ?    0.5   0.1      0.58   9.5e+02       2      19 ..     343     360 ..     337     362 .. 0.64

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 2.3
                 -HHHHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekalel 30 
                 dy  Ak  + +al+l
  EFC39461.1 104 DYGLAKDDMLEALSL 118
                 7899********997 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 6.1e-05
                 HHHHHHHHHTT-HHHHHHHHHHHHH CS
       TPR_8   5 ynlgsiylklgdyeeAkeyyekale 29 
                 y+lg++y+  gd++eA   ++k +e
  EFC39461.1 145 YLLGMCYHGNGDFKEAAIHFQKSIE 169
                 89********************997 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0084
                 HHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkeyyekalel 30 
                 y + g  y +   y + +ey+++a+el
  EFC39461.1 262 YIRAGVSYYSGTYYANGVEYFNRAIEL 288
                 7888999999999************97 PP

  == domain 4  score: 20.2 bits;  conditional E-value: 2.7e-07
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylklgdyeeAkeyyekalel 30 
                 +yyn g++y  lg++e A+e + k ++l
  EFC39461.1 300 SYYNRGLCYYYLGELETAIEDFTKSISL 327
                 8*************************98 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.58
                 CHHHHHHHHHHHTT-HHH CS
       TPR_8   2 eayynlgsiylklgdyee 19 
                   y +lg+i +k +d  +
  EFC39461.1 343 ATYGRLGMIKEKEQDEYK 360
                 457777777777666555 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       4.2   6.8e+03       8      37 ..      94     123 ..      87     130 .. 0.65
   2 !   13.4   0.0   4.3e-05      0.07      49      74 ..     145     170 ..     142     174 .. 0.75
   3 !   23.5   0.4   3.1e-08   5.1e-05      19      74 ..     275     327 ..     257     329 .. 0.83
   4 ?   -1.9   0.0       2.7   4.3e+03       3      18 ..     342     357 ..     338     362 .. 0.49

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 4.2
      TPR_12   8 nlaavlrrlgrydeAlellekaleiarrll 37 
                 ++  + +++ +y  A +   +al +++++ 
  EFC39461.1  94 QRCIARLEQPDYGLAKDDMLEALSLMNATG 123
                 555555666677778888888888887774 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 4.3e-05
      TPR_12  49 rnLgrlyralgryeeAlelleealai 74 
                 + Lg++y+  g+++eA  +++++++ 
  EFC39461.1 145 YLLGMCYHGNGDFKEAAIHFQKSIEH 170
                 56788888888888888888888775 PP

  == domain 3  score: 23.5 bits;  conditional E-value: 3.1e-08
      TPR_12  19 ydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAlelleealai 74 
                 y+   e++++a+e+ +++   +++++ ++++n g +y++lg++e A+e +++++ +
  EFC39461.1 275 YANGVEYFNRAIELGESY---QSEYLESSYYNRGLCYYYLGELETAIEDFTKSISL 327
                 8999***********888...556699*************************9976 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 2.7
      TPR_12   3 atalnnlaavlrrlgr 18 
                 a+++ +l+++  + ++
  EFC39461.1 342 AATYGRLGMIKEKEQD 357
                 4445455555544444 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0    0.0022       3.6       2      25 ..     143     166 ..     142     170 .. 0.89
   2 ?    2.2   0.1      0.21   3.3e+02       5      28 ..     264     287 ..     260     288 .. 0.88
   3 !   12.4   0.0   0.00012       0.2       2      25 ..     300     323 ..     299     326 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0022
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealer 25 
                 A y+l+++y   gd  +A   +++
  EFC39461.1 143 AEYLLGMCYHGNGDFKEAAIHFQK 166
                 77********988*****999998 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.21
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   5 klalsyrklgdtdkAlealerlik 28 
                 +++ sy++++ +++ +e+++r i+
  EFC39461.1 264 RAGVSYYSGTYYANGVEYFNRAIE 287
                 678*****99***********996 PP

  == domain 3  score: 12.4 bits;  conditional E-value: 0.00012
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
       TPR_6   2 AlyklalsyrklgdtdkAlealer 25 
                 ++y+++l+y+ lg+ ++A+e + +
  EFC39461.1 300 SYYNRGLCYYYLGELETAIEDFTK 323
                 69*********99******98876 PP

>> TPR_16  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.0   0.00097       1.6      36      64 ..     143     171 ..     139     175 .. 0.88
   2 !    7.0   0.0    0.0056       9.1      18      57 ..     280     321 ..     265     326 .. 0.74

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00097
      TPR_16  36 AllllgdaalrqgrlaeAaalyraalraa 64 
                 A +llg ++  +g+++eAa  +++ +++ 
  EFC39461.1 143 AEYLLGMCYHGNGDFKEAAIHFQKSIEHR 171
                 669*****************999988775 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0056
      TPR_16  18 aaleaalkrdpssPd...aaeAllllgdaalrqgrlaeAaaly 57 
                 +++++a++++ +s +      +++++g++++ +g+l+ A++ +
  EFC39461.1 280 EYFNRAIELG-ESYQseyLESSYYNRGLCYYYLGELETAIEDF 321
                 5666666666.33334666679******************655 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.68   1.1e+03      36      59 ..     148     171 ..     145     189 .. 0.85
   2 !   15.0   0.0   1.3e-05     0.021      32      70 ..     301     342 ..     299     344 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.68
       TPR_9  36 GlllaqlGclsaAladLeaylala 59 
                 G++++  G++++A+  ++  +++ 
  EFC39461.1 148 GMCYHGNGDFKEAAIHFQKSIEHR 171
                 899***********9999888775 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.3e-05
       TPR_9  32 rrdRGlllaqlGclsaAladLeaylalap...dapdaeaira 70 
                 ++ RGl+++ lG l++A++d+   ++l p   ++++++++ra
  EFC39461.1 301 YYNRGLCYYYLGELETAIEDFTKSISLMPllkQRDAVYLMRA 342
                 689************************999988888888886 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       2.3   3.7e+03      11      24 ..      81      94 ..      80     106 .. 0.82
   2 !    6.3   0.0    0.0068        11       4      27 ..     146     169 ..     145     183 .. 0.87
   3 !    8.1   0.1    0.0018       2.9       1      28 [.     300     327 ..     300     336 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 2.3
       TPR_7 11 rlGdyeeAielyeq 24
                +++d+e++++l+ q
  EFC39461.1 81 NDNDREQLAKLLIQ 94
                57999**9999887 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0068
       TPR_7   4 nLarlysrlGdyeeAielyeqsLa 27 
                  L+ +y+  Gd++eA+ ++++s++
  EFC39461.1 146 LLGMCYHGNGDFKEAAIHFQKSIE 169
                 69999***************9665 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.0018
       TPR_7   1 aLlnLarlysrlGdyeeAielyeqsLal 28 
                 +++n + +y  lG+ e+Aie +++s+ l
  EFC39461.1 300 SYYNRGLCYYYLGELETAIEDFTKSISL 327
                 6999*******************97754 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.1     0.016        25      25      49 ..     143     167 ..     136     174 .. 0.81
   2 ?    8.7   0.5    0.0012         2       5      49 ..     282     324 ..     271     342 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.016
                 HHHHHHHHHHHTT-HHHHHHHHHCT CS
      ANAPC3  25 dayllAlclylngqykrAyellrka 49 
                 + yll+ c+  ng++k+A   ++k+
  EFC39461.1 143 AEYLLGMCYHGNGDFKEAAIHFQKS 167
                 689*************998666665 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0012
                 HHHHHHHHHHHH.HHH--HHHHHHH.HHHHHHTT-HHHHHHHHHCT CS
      ANAPC3   5 yknAiflaerllaaetespedayll.AlclylngqykrAyellrka 49 
                 ++ Ai l+e ++   +e +e++y+  +lc+y +g+ ++A+e + k+
  EFC39461.1 282 FNRAIELGESYQ---SEYLESSYYNrGLCYYYLGELETAIEDFTKS 324
                 445666666655...77777777756*************9987776 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.31     5e+02      17      32 ..     145     160 ..     140     161 .. 0.88
   2 ?    9.0   0.1    0.0012         2      15      34 .]     300     319 ..     298     319 .. 0.94
   3 ?    0.4   0.1      0.66   1.1e+03      15      34 .]     337     356 ..     336     356 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.31
      TPR_17  17 nnLAelllknGdlmtA 32 
                 ++L+ +++ nGd+++A
  EFC39461.1 145 YLLGMCYHGNGDFKEA 160
                 67999999****9998 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.0012
      TPR_17  15 aynnLAelllknGdlmtArq 34 
                 +y+n++ +++ +G+l+tA++
  EFC39461.1 300 SYYNRGLCYYYLGELETAIE 319
                 8*****************86 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.66
      TPR_17  15 aynnLAelllknGdlmtArq 34 
                 +y ++A ++ ++G  ++++q
  EFC39461.1 337 VYLMRAATYGRLGMIKEKEQ 356
                 799**********9888876 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.5   6.3e-05       0.1       3      39 ..     376     412 ..     374     414 .. 0.91
   2 ?   -3.1   0.0       4.9     8e+03      10      22 ..     453     465 ..     447     475 .. 0.61
   3 ?   -2.7   0.0       3.7     6e+03      13      22 ..     565     574 ..     564     575 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 6.3e-05
                 HHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTT CS
       F-box   3 lsrLPsevlrhILerLplsdllalrrVSkgwrilids 39 
                 l  L ++ l+hI+++L ++ +l +++  k  r+l++s
  EFC39461.1 376 LRLLDDDTLCHIMSFLQTRQVLVMSSLNKYSRNLVKS 412
                 55688999**************************997 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 4.9
                 HHHHHHHTS-HHH CS
       F-box  10 vlrhILerLplsd 22 
                  ++h+L++  l++
  EFC39461.1 453 MVNHVLQHSLLKH 465
                 5677777744444 PP

  == domain 3  score: -2.7 bits;  conditional E-value: 3.7
                 HHHHTS-HHH CS
       F-box  13 hILerLplsd 22 
                 +I e+Lp +d
  EFC39461.1 565 QIVEYLPITD 574
                 799****998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (622 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       958  (0.053433); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.49
# Mc/sec: 3805.08
//
Query:       EFC39462.1  [L=607]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-08   32.3   3.0    1.1e-07   31.3   3.0    1.6  1  SHOCT     Short C-terminal domain


Domain annotation for each model (and alignments):
>> SHOCT  Short C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.3   3.0   6.3e-12   1.1e-07       3      28 .]     580     605 ..     580     605 .. 0.96

  Alignments for each domain:
  == domain 1  score: 31.3 bits;  conditional E-value: 6.3e-12
       SHOCT   3 LekLkeLyarGeIteEEFeakKakLL 28 
                 L+kL eL+ +G++teEEF+akK++ L
  EFC39462.1 580 LKKLGELRKAGILTEEEFQAKKKQVL 605
                 89*********************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (607 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.49
# Mc/sec: 3754.94
//
Query:       EFC39463.1  [L=434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.6e-11   43.5   0.0     0.0013   19.3   0.0    5.0  5  RCC1      Regulator of chromosome condensation (RCC1) repeat
    4.5e-10   39.1  13.4    5.8e-05   22.8   0.9    5.1  6  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.22     2e+03      36      49 ..      48      61 ..      29      62 .. 0.78
   2 ?    2.1   0.0     0.033     3e+02      25      50 .]     142     172 ..     122     172 .. 0.73
   3 !   11.3   0.0   4.7e-05      0.42       1      50 []     175     225 ..     175     225 .. 0.76
   4 ?    3.6   0.0     0.012   1.1e+02       3      43 ..     230     270 ..     228     276 .. 0.74
   5 !   19.3   0.0   1.4e-07    0.0013       6      50 .]     285     331 ..     283     331 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.22
                -EEEEEEETTEEEE CS
        RCC1 36 rvvkvacGddhtva 49
                ++ ++++G d+ ++
  EFC39463.1 48 DICDIVAGEDFAIF 61
                899*******9887 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.033
                 EEEE-GGGTTS.....-EEEEEEETTEEEEE CS
        RCC1  25 vPtkveglsgn.....rvvkvacGddhtval 50 
                  Pt+++ ls +     r+v+   G+ h ++l
  EFC39463.1 142 QPTLLSKLSMDlfggeRIVHCGLGNEHALFL 172
                 3877766665566677***********9986 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 4.7e-05
                 TTEEEEEE--GGGTTSS....SS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGl....gttesvlvPtkveglsgnrvvkvacGddhtval 50 
                 +G+V++ G n+ GqL +     +++ v +Pt   +    ++vkv++ ++ +++l
  EFC39463.1 175 SGKVFGSGANSSGQLANakwySDQKFVQLPTDHIPD---KIVKVFATYNTSFVL 225
                 59***************6554333333558877553...9******99999986 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.012
                 EEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacG 43 
                 +V+s+G  +y+  G++ ++++ +  +v+ + ++++v++  G
  EFC39463.1 230 EVWSCGDTTYNASGHKANQNNKTTELVKIPIDEKIVDIEPG 270
                 7**************99977755555555555677777666 PP

  == domain 5  score: 19.3 bits;  conditional E-value: 1.4e-07
                 EEE--GGGTTSSSS-..--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   6 sWGrndyGqLGlgtt..esvlvPtkveglsgnrvvkvacGddhtval 50 
                  +G n++ q G+  t  e+ + P  + ++++++++k++cG++ ++ +
  EFC39463.1 285 VFGYNNFSQFGRSETlaERIDGPHPLDTFPNENIQKIVCGGYNSIII 331
                 69**********9999888899********99**********99875 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.1     0.033     3e+02       1      21 [.      49      69 ..      49      74 .. 0.86
   2 ?   -2.1   0.0      0.41   3.7e+03      11      21 ..     117     128 ..     115     128 .. 0.72
   3 !   22.8   0.9   6.5e-09   5.8e-05       7      30 .]     165     188 ..     161     188 .. 0.97
   4 !   16.7   0.1   5.1e-07    0.0045       1      25 [.     212     236 ..     212     243 .. 0.86
   5 ?   -2.9   0.0      0.74   6.7e+03      21      30 .]     284     293 ..     284     293 .. 0.80
   6 !    3.2   0.0    0.0087        78       3      19 ..     320     336 ..     318     342 .. 0.79

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.033
      RCC1_2  1 VksvsaGdyHscaLtedGeVl 21
                + ++ aG ++++++ + G+ +
  EFC39463.1 49 ICDIVAGEDFAIFVNRAGNCY 69
                5799******99999988765 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.41
      RCC1_2  11 scaLted.GeVl 21 
                 +c+L++  G V+
  EFC39463.1 117 FCVLVNRhGQVY 128
                 699997548776 PP

  == domain 3  score: 22.8 bits;  conditional E-value: 6.5e-09
      RCC1_2   7 GdyHscaLtedGeVlcWGsNsdGQ 30 
                 G+ H+++Lte+G+V++ G Ns+GQ
  EFC39463.1 165 GNEHALFLTESGKVFGSGANSSGQ 188
                 899********************9 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 5.1e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGs 25 
                 +++v a ++ s++Lte++eV+++G+
  EFC39463.1 212 IVKVFATYNTSFVLTENNEVWSCGD 236
                 6788889999**************8 PP

  == domain 5  score: -2.9 bits;  conditional E-value: 0.74
      RCC1_2  21 lcWGsNsdGQ 30 
                 l +G N++ Q
  EFC39463.1 284 LVFGYNNFSQ 293
                 579*9*9876 PP

  == domain 6  score: 3.2 bits;  conditional E-value: 0.0087
      RCC1_2   3 svsaGdyHscaLtedGe 19 
                 ++ +G+y s++++ d +
  EFC39463.1 320 KIVCGGYNSIIISQDRK 336
                 799*********99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       307  (0.0171231); expected 358.6 (0.02)
Passed bias filter:                      267  (0.0148921); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 2836.56
//
Query:       EFC39464.1  [L=1651]
Description: ATP dependent helicase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.9e-12   47.4   0.0    1.9e-12   47.4   0.0    2.0  1  HA2           Helicase associated domain (HA2)
    4.9e-12   45.9  27.4    1.8e-07   31.2   6.9    4.6  2  IBR           IBR domain, a half RING-finger domain
      4e-11   42.8   1.7      8e-05   22.8   0.1    3.1  2  Kelch_6       Kelch motif
    7.5e-10   39.0   0.1    3.1e-09   37.1   0.0    2.1  2  OB_NTP_bind   Oligonucleotide/oligosaccharide-binding (OB)-fo
    1.3e-06   28.5   0.1      0.041   14.2   0.0    3.7  3  Kelch_3       Galactose oxidase, central domain
    2.9e-06   27.2   0.2    0.00041   20.3   0.0    2.9  3  Kelch_4       Galactose oxidase, central domain
    3.8e-06   26.4   4.4      0.043   13.4   0.1    3.7  4  Kelch_1       Kelch motif
    5.4e-05   22.9   0.6     0.0034   17.2   0.5    3.2  2  KH_1          KH domain
    0.00041   20.3  13.6    0.00041   20.3  13.6    3.9  2  zf-RING_UBOX  RING-type zinc-finger
     0.0073   16.3   0.2        2.3    8.3   0.1    3.0  2  Kelch_2       Kelch motif
     0.0074   16.1   8.9      0.071   12.9   0.4    3.9  4  SLS           Mitochondrial inner-membrane-bound regulator
     0.0083   16.0  11.6     0.0083   16.0  11.6    4.8  2  zf-C3HC4_3    Zinc finger, C3HC4 type (RING finger)
  ------ inclusion threshold ------
      0.087   12.8   0.0        7.2    6.7   0.0    3.3  3  Kelch_5       Kelch motif


Domain annotation for each model (and alignments):
>> HA2  Helicase associated domain (HA2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.4   0.0   1.4e-15   1.9e-12       1      78 [.     673     768 ..     673     816 .. 0.78

  Alignments for each domain:
  == domain 1  score: 47.4 bits;  conditional E-value: 1.4e-15
         HA2   1 AlelLvalgALdeegnlTelGrkmaelPlsprlakmLlaaaeleegcldevitivAalsveeifleeneeekeeeee....................e 78 
                 +l++L++l+ +de++n+T++G++ +++ ++p+la+m++ +++l  g+ de+i++v+++s ++++  ++++ +  e++                    +
  EFC39464.1 673 SLKNLTDLQFVDEKQNITQMGKQASKMEIEPSLARMIIEGINL--GIGDEIIQLVSIMSFSNMIYAKSKSTDYLEKDimkvstskeggdlitllhifQ 768
                 6899************************************777..***************99999999887776666666666666655555554441 PP

>> IBR  IBR domain, a half RING-finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.4  12.5   2.4e-10   3.3e-07       3      62 .]    1526    1585 ..    1524    1585 .. 0.89
   2 !   31.2   6.9   1.3e-10   1.8e-07      12      53 ..    1594    1634 ..    1587    1640 .. 0.90

  Alignments for each domain:
  == domain 1  score: 30.4 bits;  conditional E-value: 2.4e-10
         IBR    3 yeklklkkslesdpn.lkwCprpdCeaiieksegcksvtCskCgfefCfnCkkewHeglsC 62  
                    +++ +k+le +pn +k+C ++ C++i+  +++ + ++C++C++ +C++C+++ H+gl+C
  EFC39464.1 1526 QAQYAVEKYLERHPNdFKHCSSAHCSGIVCIDQS-QVAHCQSCNKTYCIKCNEPPHPGLDC 1585
                  568999******9888**********99977777.3457*********************9 PP

  == domain 2  score: 31.2 bits;  conditional E-value: 1.3e-10
         IBR   12 les.dpnlkwCprpdCeaiieksegcksvtCskCgfefCfnCk 53  
                  +e+ + n+k Cp  +C++ iek+ gc+++tC  Cg  fC+ C+
  EFC39464.1 1594 IEWkKANTKPCP--KCKNNIEKNGGCNHITCYYCGAHFCWLCG 1634
                  6776889*****..****************************7 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.1   5.8e-08     8e-05       4      49 ..     116     163 ..     113     165 .. 0.91
   2 !   18.0   0.2   1.8e-06    0.0025       5      43 ..     169     208 ..     164     216 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 5.8e-08
     Kelch_6   4 ghslvsvggkiYifGGytds..spylnkvwvydpetksWeqlpplpvp 49 
                 ++ + s  + iYi+GG +ds  s+y ++v ++++et +We +++++++
  EFC39464.1 116 PPIADSKRNCIYIVGGISDSgaSQYAKDVVKISLETFVWEVIGSINIY 163
                 5567788999**********************************9964 PP

  == domain 2  score: 18.0 bits;  conditional E-value: 1.8e-06
     Kelch_6   5 hslvsvgg.kiYifGGytdsspylnkvwvydpetksWeql 43 
                  s+ ++ + +i +fGGy+ s +++++++ +++++k W++l
  EFC39464.1 169 QSSLLWKEkFIIVFGGYNTSCSATSDILAFNVDSKEWSTL 208
                 4556688769**********77889************986 PP

>> OB_NTP_bind  Oligonucleotide/oligosaccharide-binding (OB)-fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       6.2   8.6e+03      34      49 ..     449     464 ..     448     465 .. 0.70
   2 !   37.1   0.0   2.3e-12   3.1e-09       2      79 ..     825     903 ..     824     905 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 6.2
                  E-TTSTTTTT...TSS CS
  OB_NTP_bind  34 ihpsSvlaknekekep 49 
                  +h  Sv++ ++++k+p
   EFC39464.1 449 FHRRSVNFTQQQQKPP 464
                  799*****75455544 PP

  == domain 2  score: 37.1 bits;  conditional E-value: 2.3e-12
                  HHHHHHHHTTCEEEEEE...TTCCEEETTTCEEEEE-TTSTTTTT...TSSSEEEEEEEEESSSEEEEEEEEE-HHHHHHH CS
  OB_NTP_bind   2 raillaGlypqiarkdp...skkdyktartktrvfihpsSvlaknekekepewvvytelvettklylrdltaidpawLllf 79 
                   ++++ +++++ a+       k+ yk ++ + ++fih sS  +   ++++ ++v+y elv+t kl+++++t+i+ +++ +f
   EFC39464.1 825 TRCVCCSMFDNFAYFHGiinGKRVYKILSSNMEAFIHGSSFSNY--SSEPIDYVIYGELVKTEKLFMKNVTPISLESIKPF 903
                  678999999999975556646777****99*********98775..679999**********************9998777 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.5   0.0    0.0017       2.4       2      36 ..     124     159 ..     123     172 .. 0.83
   2 !   14.2   0.0     3e-05     0.041       3      34 ..     178     208 ..     176     218 .. 0.88
   3 ?    1.0   0.0       0.4   5.6e+02       2      33 ..     253     290 ..     252     299 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0017
     Kelch_3   2 drlyifGGlgddg.qdrlndvyvydldtntWaeias 36 
                 +++yi+GG  d+g  ++ +dv  ++l+t  W+ i+s
  EFC39464.1 124 NCIYIVGGISDSGaSQYAKDVVKISLETFVWEVIGS 159
                 78*********5559999*********999998865 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 3e-05
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydldtntWaei 34 
                 ++ +fGG++ ++  +++d +++++d+ +W ++
  EFC39464.1 178 FIIVFGGYN-TSCSATSDILAFNVDSKEWSTL 208
                 689******.89*****************976 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.4
     Kelch_3   2 drlyifGGlgd.....dg.qdrlndvyvydldtntWae 33 
                 ++l i+GG+ d     +  + ++++v+++ ld  +W +
  EFC39464.1 253 NTLIIYGGNIDcfvekTQiNRPTHQVFLFHLDESEWNS 290
                 8999****999999875569999999999999988865 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.057        79      15      45 ..     126     158 ..     119     160 .. 0.81
   2 !   20.3   0.0     3e-07   0.00041       2      44 ..     165     208 ..     164     213 .. 0.90
   3 ?   -2.8   0.0         5   6.9e+03      10      20 ..     250     260 ..     248     261 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.057
     Kelch_4  15 iylfGGrgedg..tllndlylldlstntWrrlg 45 
                 iy++GG+++ g  +  +d+ +++l+t  W+ +g
  EFC39464.1 126 IYIVGGISDSGasQYAKDVVKISLETFVWEVIG 158
                 9**********9988888888888887776665 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 3e-07
     Kelch_4   2 Raghsatsi.pdgtiylfGGrgedgtllndlylldlstntWrrl 44 
                  +++++  +     i++fGG+++  ++ +d+ ++++ +++W++l
  EFC39464.1 165 AMYCQSSLLwKEKFIIVFGGYNTSCSATSDILAFNVDSKEWSTL 208
                 67888888878899*********989***************987 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 5
     Kelch_4  10 ipdgtiylfGG 20 
                 ++ +t++++GG
  EFC39464.1 250 TQENTLIIYGG 260
                 4789******9 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.1   3.1e-05     0.043      11      43 ..     123     158 ..     121     160 .. 0.94
   2 !   11.6   0.1   0.00011      0.16      14      41 ..     179     207 ..     179     208 .. 0.95
   3 ?    0.1   0.0      0.46   6.3e+02      12      40 ..     253     289 ..     249     290 .. 0.89
   4 ?   -3.7   0.0       6.8   9.3e+03       6      17 ..    1562    1573 ..    1560    1573 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 3.1e-05
                 TTEEEEEEEBCS...SSBEEEEEEEETTTTEEEEEC CS
     Kelch_1  11 ggkiYviGGsdg...gnalssvevyDpetntWrelp 43 
                 +++iY++GG ++   +++ ++v  +++et  W+ + 
  EFC39464.1 123 RNCIYIVGGISDsgaSQYAKDVVKISLETFVWEVIG 158
                 599*****************************9875 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00011
                 EEEEEEBCS.SSBEEEEEEEETTTTEEEE CS
     Kelch_1  14 iYviGGsdg.gnalssvevyDpetntWre 41 
                 i v+GG++  ++a+s++ ++++ +++W+ 
  EFC39464.1 179 IIVFGGYNTsCSATSDILAFNVDSKEWST 207
                 78*************************96 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.46
                 TEEEEEEEBCS........SSBEEEEEEEETTTTEEE CS
     Kelch_1  12 gkiYviGGsdg........gnalssvevyDpetntWr 40 
                 + + + GG  +        +++++ v+ + + + +W 
  EFC39464.1 253 NTLIIYGGNIDcfvektqiNRPTHQVFLFHLDESEWN 289
                 7788999999999999999*****************6 PP

  == domain 4  score: -3.7 bits;  conditional E-value: 6.8
                  EEEEETTEEEEE CS
     Kelch_1    6 gavvvggkiYvi 17  
                  +++  ++k Y+i
  EFC39464.1 1562 AHCQSCNKTYCI 1573
                  789999****98 PP

>> KH_1  KH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.15   2.1e+02       7      32 ..     992    1018 ..     987    1034 .. 0.70
   2 !   17.2   0.5   2.5e-06    0.0034      14      65 ..    1403    1449 ..    1399    1450 .. 0.89

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.15
                  GGGHHHHHHTGGGHHHHHHH.HHH.T-E CS
        KH_1    7 PsslvgriIGkgGsnIkeIr.eet.gak 32  
                  +s+ v+++IG+g +++k +   e  +++
  EFC39464.1  992 DSK-VRALIGRGMQVVKLLFpGEFvKCN 1018
                  555.*********999987654555555 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 2.5e-06
                  HHTGGGHHHHHHHHHHT-EEEEESSTT...T.-EEEEEE.SHHHHHHHHHHHH CS
        KH_1   14 iIGkgGsnIkeIreetgakIkvpksedegsderevtisG.speavekAkelie 65  
                  iIG++G+++k+++e++g +I+++       +++++ i   ++e +++ k++i+
  EFC39464.1 1403 IIGNQGKVLKSLQEKYGGRIDFD-Y-----KQKIISINSsDQEEINNFKQEIR 1449
                  9*************99*****97.4.....4689***8879999999999886 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.1      0.68   9.4e+02       2      11 ..      41      50 ..      41      53 .. 0.91
   2 !   20.3  13.6     3e-07   0.00041       1      38 [.    1467    1502 ..    1467    1503 .. 0.87

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.68
  zf-RING_UBOX  2 pIClelftdP 11
                  pICle+ t+P
    EFC39464.1 41 PICLESSTEP 50
                  9*****9999 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 3e-07
  zf-RING_UBOX    1 CpIClelftdPlv.lpCGHtFCreClwelskslegafkC 38  
                    CpIC+ + ++P v l+CGH++Cr+C   + +  +++f C
    EFC39464.1 1467 CPICYGPKENP-VlLSCGHSLCRDCF--ICQLDQMTFNC 1502
                    ***********.636**********9..77777888877 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.025        35      10      22 ..     122     133 ..     113     155 .. 0.72
   2 !    8.3   0.1    0.0017       2.3       2      44 ..     166     207 ..     165     208 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.025
     Kelch_2  10 pggkiyvvGGaht 22 
                  +++iy+vGG+ +
  EFC39464.1 122 KRNCIYIVGGI-S 133
                 489*******9.2 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0017
     Kelch_2   2 rgghsssvpggk.iyvvGGahtdnpnls.ssdvhvldlekhvWee 44 
                 ++++ss  +  k i+v+GG+   n+++s +sd+  ++ ++++W+ 
  EFC39464.1 166 MYCQSSLLWKEKfIIVFGGY---NTSCSaTSDILAFNVDSKEWST 207
                 67888888866648899***...7776549*************86 PP

>> SLS  Mitochondrial inner-membrane-bound regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       2.8   3.9e+03      37      73 ..     223     260 ..     221     265 .. 0.79
   2 ?   -3.3   1.0       4.8   6.6e+03     175     210 ..     505     540 ..     462     543 .. 0.67
   3 !    6.0   0.0    0.0067       9.2      32      96 ..     921     987 ..     907    1006 .. 0.81
   4 !   12.9   0.4   5.1e-05     0.071      40      95 ..    1403    1459 ..    1395    1467 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 2.8
         SLS  37 fflLl.tgngklLqnlsrihgakielnrsenklritAt 73 
                 ++lL  +g + + ++++ + +++i  n +en+l+i++ 
  EFC39464.1 223 IYLLVeAGMQLVTNKWASQFDKSIPSNTQENTLIIYGG 260
                 566665555666677889999**************985 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 4.8
         SLS 175 lseallavtssskskn.ttlrlvekekdypfrdeesl 210
                 l +++  ++sss+s+n t++ +v++e dy +++++s 
  EFC39464.1 505 LDQVE-ITSSSSNSSNsTNFGNVDTEGDYIMKENSST 540
                 33333.3455555666678888888888887776665 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0067
         SLS  32 lsprefflLltgngklLqnlsrihgakielnrsenklrit.Atkstaeyieasineil.knittetv 96 
                 l    f+ L ++ng lL+ l+ + g  +e+++++n+l ++ +   ++e+i++ + +++ ++ ++e +
  EFC39464.1 921 LTRGIFDCLNANNGALLEYLRLNIGSIVEMDPDRNELVVYlSEGDQVETILKYVYDTAvQRSNNEFL 987
                 66778999************999*****************9999*******9997765144444444 PP

  == domain 4  score: 12.9 bits;  conditional E-value: 5.1e-05
         SLS   40 LltgngklLqnlsrihgakielnrsenklrit.Atkstaeyieasineilknittet 95  
                  +++++gk+L+ l+++ g +i+++ +++ ++i+ ++++ +++ +++i++il++ +t++
  EFC39464.1 1403 IIGNQGKVLKSLQEKYGGRIDFDYKQKIISINsSDQEEINNFKQEIRNILESHQTTN 1459
                  66899***************************999****************988865 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0  11.6     6e-06    0.0083       3      44 ..    1465    1506 ..    1463    1510 .. 0.91
   2 ?    3.4   1.0     0.052        72      34      49 ..    1597    1613 ..    1584    1614 .. 0.84

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 6e-06
                  SB-TTTSSSBS-EEETTEEEEEE-HHHHHHHHH.TT-B-TTT- CS
  zf-C3HC4_3    3 eeCviClerprnvvllpCgHlvlCeeCaekllk.rkkkCpiCr 44  
                  e C+iC+  ++n vll CgH  lC +C+   l+ ++ +C  C 
  EFC39464.1 1465 EDCPICYGPKENPVLLSCGHS-LCRDCFICQLDqMTFNCCECD 1506
                  57*******************.******998888999999996 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.052
                  HH.TT-B-TTT--B--E CS
  zf-C3HC4_3   34 lk.rkkkCpiCrrpiek 49  
                  +k ++k Cp C+ +iek
  EFC39464.1 1597 KKaNTKPCPKCKNNIEK 1613
                  445899********986 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.0       0.2   2.8e+02      15      34 ..     124     144 ..     113     152 .. 0.70
   2 ?    6.7   0.0    0.0052       7.2      15      41 ..     177     202 ..     164     203 .. 0.76
   3 ?   -1.6   0.0       2.1     3e+03      12      24 ..     250     262 ..     245     267 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.2
     Kelch_5  15 ekiYvyGGkvg.rdgsvsddv 34 
                 + iY+ GG++    +++  dv
  EFC39464.1 124 NCIYIVGGISDsGASQYAKDV 144
                 67********65566666666 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0052
     Kelch_5  15 ekiYvyGGkvgrdgsvsddvyvLdlps 41 
                   i+v+GG+++ + s+++d++ +++ s
  EFC39464.1 177 KFIIVFGGYNT-SCSATSDILAFNVDS 202
                 45********6.889999999888876 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 2.1
     Kelch_5  12 tvsekiYvyGGkv 24 
                 t ++ +++yGG +
  EFC39464.1 250 TQENTLIIYGGNI 262
                 566789*****86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1651 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1850  (0.103185); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 1.06u 0.37s 00:00:01.43 Elapsed: 00:00:00.58
# Mc/sec: 8557.94
//
Query:       EFC39465.1  [L=375]
Description: hypothetical protein NAEGRDRAFT_72694 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   6.2e-123  410.4   0.0   3.5e-122  407.9   0.0    1.8  1  Actin     Actin
     0.0037   16.1   0.0      0.048   12.5   0.0    2.2  2  MreB_Mbl  MreB/Mbl protein


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  407.9   0.0  3.9e-126  3.5e-122       2     407 .]       3     375 .]       2     375 .] 0.97

  Alignments for each domain:
  == domain 1  score: 407.9 bits;  conditional E-value: 3.9e-126
       Actin   2 devsavVlDnGssttraGyagedaPkavipslvgkprgrkvea....klyvgde.altkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeeh 95 
                 +e sa+VlDnGs++++aG++g ++P++v+psl+++p ++k+++     ++vgde ++++r+++ vr+p+e+Gvv++w+ +e++w+hv+ + l+vd e+h
  EFC39465.1   3 QEYSAIVLDNGSCSIKAGFSGCENPQVVFPSLIASPLKSKESEnikeIYLVGDEaKIDSRKNVMVRYPIEHGVVTNWEGMEQIWRHVFSQ-LQVDCENH 100
                 6889******************************8888776657777899****66669****************************987.******** PP

       Actin  96 pllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvev 194
                 p+llt+pp np+++rek++Ei+fE+f++p++y++  avls+fa+g++tg+v+DsG++ t +vp+++  +L++a+rr+d +G++L+ ++ ++ls++    
  EFC39465.1 101 PVLLTQPPCNPKQNREKMTEIMFETFRIPSMYVSIPAVLSLFATGRTTGIVLDSGDGATNIVPIFESHALEYAVRRLDWAGRDLDYYMSRILSER---- 195
                 **********************************************************************************************8.... PP

       Actin 195 tprylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligses 293
                                           + s+ t ee+ +++eiKe++c+v+ d+ ++ e+ s+s +++YeLPDg+ +++g+eRf++pE+ F+p+lig e+
  EFC39465.1 196 --------------------------GFSFFTREEMDIVREIKEKLCYVALDFDKEMENTSNSLDVDYELPDGNILTIGNERFRCPEVFFKPHLIGIEE 268
                 ..........................78**************************9999999************************************99 PP

       Actin 294 aleeekskllgiselivaainacdvdl.rpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapee.erkysaWiGGSiLAslgtfqqlwvs 390
                 +         gi+e+i+++i +cdvd+ + +L+ n+v++GG++++ g+ +Rl+kel++la+ ++k+ ++ +   +rk+ +WiGGSiL+s+  fq+ w+ 
  EFC39465.1 269 Q---------GIHEVIINSIGKCDVDIgHLNLYGNVVLSGGSTMFTGIGKRLQKELSELAPYSMKISVVDSLGfDRKFLSWIGGSILSSMTAFQSDWIV 358
                 9.........*****************999*****************************************999************************* PP

       Actin 391 kqEYeEqGssvverkck 407
                  +EY+E Gss+v+rkc+
  EFC39465.1 359 SREYKEVGSSIVHRKCF 375
                 ****************6 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.0   5.4e-06     0.048      35     104 ..      46     110 ..      10     185 .. 0.84
   2 ?    1.4   0.0     0.012   1.1e+02     275     297 ..     293     315 ..     267     328 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 5.4e-06
                 TT--EEEESHHHHTTTTS-GTTEEEE-SEETTEESSHHHHHHHHHHHHHHHHTSS-SS--EEEEEE-SS- CS
    MreB_Mbl  35 ktkkvlavGeeAkkmlgktpgnikavrPlkdGviadlevaeellkyfikkvkkkkslskprvvicvPsgi 104
                 + k+++ vG+eAk     +++n+ +  P+++Gv+++ e  e++ ++++++++ +  +++  v+++ P + 
  EFC39465.1  46 NIKEIYLVGDEAKI---DSRKNVMVRYPIEHGVVTNWEGMEQIWRHVFSQLQVD--CENHPVLLTQPPCN 110
                 3688999*****95...57899****************************9986..56666666666554 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.012
                 H-EEEESGGGGSBTHHHHHHHHH CS
    MreB_Mbl 275 rgivltGGgallkgldkllseet 297
                   +vl+GG++++ g+ k l++e+
  EFC39465.1 293 GNVVLSGGSTMFTGIGKRLQKEL 315
                 5699***************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       357  (0.0199119); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2324.82
//
Query:       EFC39466.1  [L=103]
Description: histone H4 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.7e-10   40.3   0.1    3.3e-10   40.0   0.1    1.1  1  CENP-T_C        Centromere kinetochore component CENP-T histo
    2.3e-05   24.8   0.1    2.6e-05   24.6   0.1    1.2  1  Histone         Core histone H2A/H2B/H3/H4
    7.3e-05   22.9   0.1     0.0001   22.4   0.1    1.3  1  TAF             TATA box binding protein associated factor (T
    0.00012   22.3   0.0    0.00017   21.8   0.0    1.3  1  CBFD_NFYB_HMF   Histone-like transcription factor (CBF/NF-Y) 
    0.00014   22.1   0.2    0.00017   21.9   0.2    1.3  1  CENP-S          CENP-S protein
    0.00054   20.0   0.0    0.00066   19.7   0.0    1.1  1  TFIID-31kDa     Transcription initiation factor IID, 31kD sub
      0.007   16.3   0.1     0.0099   15.9   0.1    1.2  1  Bromo_TP        Bromodomain associated
  ------ inclusion threshold ------
      0.029   14.3   0.2      0.035   14.0   0.2    1.2  1  Ribosomal_S17e  Ribosomal S17


Domain annotation for each model (and alignments):
>> CENP-T_C  Centromere kinetochore component CENP-T histone fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.0   0.1   1.5e-13   3.3e-10      13      79 ..      30      96 ..      20      99 .. 0.87

  Alignments for each domain:
  == domain 1  score: 40.0 bits;  conditional E-value: 1.5e-13
    CENP-T_C 13 vkklakrfakasgskaklekealkalekasdkffeqvgeDLeayakHagRKtidesDvilLmkrqrk 79
                + k a r   ++g  ++++ + ++   +++++f+e v +D  +y++Ha+RKt+ + Dv+  +krq++
  EFC39466.1 30 ITKPAIRRLARRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALKRQGR 96
                45555555555677889************************************************86 PP

>> Histone  Core histone H2A/H2B/H3/H4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.1   1.1e-08   2.6e-05      77     129 ..      40      92 ..      16      94 .. 0.88

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 1.1e-08
                 TTSSSXEEXHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXSEEXHHHHHHHHH CS
     Histone  77 sekedlrisaeavlalqealEallvelfeeAnllakhaKRvTitpkDiqlArr 129
                 +++  +ris++  +   ++l+++l+ +  +A  +++ha+R+T+t+ D+  A++
  EFC39466.1  40 RRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALK 92 
                 467788999999999999******************************99987 PP

>> TAF  TATA box binding protein associated factor (TAF)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.1   4.5e-08    0.0001       5      66 .]      31      92 ..      27      92 .. 0.85

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 4.5e-08
                -HHHHHHHHHHTT---B-HHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-SSB-HHHHHHHH- CS
         TAF  5 pkesvkviAeslGitnLsdeaaalLaedveyrlkeivqeaakfmrhskRqkLtvaDvdsALr 66
                +k +++ +A   G++ +s     +    ++  l +++++a+ +++h++R++ t+ Dv +AL+
  EFC39466.1 31 TKPAIRRLARRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALK 92
                66677888888888888877777777777888999*************************98 PP

>> CBFD_NFYB_HMF  Histone-like transcription factor (CBF/NF-Y) and archaeal histone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.8   0.0   7.5e-08   0.00017       7      65 .]      34      91 ..      28      91 .. 0.91

  Alignments for each domain:
  == domain 1  score: 21.8 bits;  conditional E-value: 7.5e-08
                   HHHHHHHCCTTXS-B-HHHHHHHHHHHHHHHHHHHHHHHHHHCCTTSSCE-HHHHHHHH CS
  CBFD_NFYB_HMF  7 rvkkImksdpdarkiakdAkeliaecveefieelaseAaeickkekrKtikaehiklAv 65
                   +++++ +   ++++i+ +  +    +++ f+e + + A+ ++++++rKt++  ++  A+
     EFC39466.1 34 AIRRLARRG-GVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYAL 91
                   578888888.999999999999999*****************************98876 PP

>> CENP-S  CENP-S protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.2   7.7e-08   0.00017      40      73 ..      61      94 ..      23      97 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 7.7e-08
      CENP-S 40 kqlenlakDLeaFakHAkRstittdDvlLlaRrn 73
                + len+ +D  ++ +HA+R+t+t  Dv+  ++r+
  EFC39466.1 61 NFLENVIRDAVTYTEHARRKTVTSMDVVYALKRQ 94
                56899**********************9998885 PP

>> TFIID-31kDa  Transcription initiation factor IID, 31kD subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.0     3e-07   0.00066      11      70 ..      35      94 ..      31     101 .. 0.88

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 3e-07
  TFIID-31kDa 11 ihliLaslgvteyeerVvlqLldfayrytssvLedAkvlaehakkkevslddvrlAiqsr 70
                 i+ + +  gv+ ++ ++++    +  ++  +v++dA ++ eha++k+v+  dv  A++ +
   EFC39466.1 35 IRRLARRGGVKRISGQIYDETRTVLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALKRQ 94
                 566667789999999999999999******************************999865 PP

>> Bromo_TP  Bromodomain associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.1   4.4e-06    0.0099      35      70 ..      58      93 ..      46      97 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 4.4e-06
                HHHHHHHHHHHHHHHHHTTSS-SS--HHHHHHHHHH CS
    Bromo_TP 35 iaqkYirelgeqaksfaehagRseptlkDvvltLqe 70
                +++++++++ ++a  + eha+R ++t  Dvv +L++
  EFC39466.1 58 VLKNFLENVIRDAVTYTEHARRKTVTSMDVVYALKR 93
                78899999**************************97 PP

>> Ribosomal_S17e  Ribosomal S17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.2   1.5e-05     0.035      43      86 ..      20      64 ..      14      93 .. 0.82

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.5e-05
                    -SHHHHHHHHHHHHHHHH.TTSS--SS---HHHHHHHHHHH---- CS
  Ribosomal_S17e 43 skklrnkiaGyvthlmkr.iqkgpvrgislklqeeererrdnyvp 86
                     k lr +iaG ++  ++r  ++g v+ is ++ +e r   +n+  
      EFC39466.1 20 KKVLRDNIAGITKPAIRRlARRGGVKRISGQIYDETRTVLKNFLE 64
                    5789**************6689***********999987777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (103 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       722  (0.04027); expected 358.6 (0.02)
Passed bias filter:                      587  (0.0327403); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.53u 0.36s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 575.87
//
Query:       EFC39467.1  [L=471]
Description: silent information regulator family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-52  177.6   0.6    2.4e-51  174.2   0.0    2.2  2  SIR2      Sir2 family
    7.8e-17   61.4  17.8    7.8e-17   61.4  17.8    2.0  2  zf-UBP    Zn-finger in ubiquitin-hydrolases and other protein
  ------ inclusion threshold ------
       0.22   11.6   0.0       0.49   10.5   0.0    1.6  2  Milton    Kinesin associated protein


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   1.0     0.062   3.7e+02      97     134 ..      61     112 ..      55     154 .. 0.71
   2 !  174.2   0.0     4e-55   2.4e-51       1     177 []     196     384 ..     196     384 .. 0.93

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.062
                 ETTEEEEEEEETTTSBEEECCGGHCHHHCCTT...............B-TTT CS
        SIR2  97 elHGslakakcvkcekkldkeelqeeieaekvp..............ecekc 134
                 ++H ++++  c kc+  +   + ++++ ++ ++               c +c
  EFC39467.1  61 HCHSTAENWFCLKCQDVCCSRYQKSHMLHHYEKtghalvlsladhslYCYEC 112
                 8999999999***999776655444444333324455666666655555555 PP

  == domain 2  score: 174.2 bits;  conditional E-value: 4e-55
                 -GGGGGGGT---SSS.TTSHHHHSCHHHHSSHHHHHHHHHHHHH..HHHHHHHHHHCCTSS--HHHHHHHHHHHTTCEEEEEES-SSSHHHHTT-S..S CS
        SIR2   1 GAGiStesGipdfRs.keGlyaklakeelaspealfskkllvee..vfyniarellaeeaepnaaHkalkklekkgkllrliTQNiDgLekkaGsk..k 94 
                 GAG+St++GipdfR   +Gly++l+k++l +p+a+f+ k+l ++  +f ++ r+ ++  ++p++aH+++k le+k+kl+rl+TQNiDgLe k+G++  +
  EFC39467.1 196 GAGLSTSAGIPDFRTpGTGLYDNLQKYNLPHPTAIFELKYLPTNphPFFHLSRDFISSGYKPTKAHYFIKLLEEKNKLKRLYTQNIDGLEAKSGITkeH 294
                 9**************9*************************999999************************************************9899 PP

                 EEETTEEEEEEEETTTSBEEECCGGHCHHH...CCTT.B-TTTCCBEEEEE--CTSB-SHHHHHHHH.HH...HH-SEEEEES--STSTT CS
        SIR2  95 vvelHGslakakcvkcekkldkeelqeeie...aekvpecekcgkllkpdvvfFGealpdklkklie.kv...eeadlllviGtSlkVap 177
                 +v++HG     +c++c+k+++ +e+ +++    + ++p+c+kcg+++kpd+v+FGe+lp+k+ ++++ ++   +++++++viGtSl+V+p
  EFC39467.1 295 LVNCHGMYDIGHCIECSKEYSLSEIVKKMGtdeEVQIPKCDKCGHIVKPDIVLFGESLPNKYVDCCKsDLlrsKDCEVFIVIGTSLSVYP 384
                 *************************9999732244678*********************9999988865433389*************98 PP

>> zf-UBP  Zn-finger in ubiquitin-hydrolases and other protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.4  17.8   1.3e-20   7.8e-17       1      63 [.      59     120 ..      59     121 .. 0.97
   2 ?   -3.0   0.1       1.6   9.7e+03      14      20 ..     334     340 ..     327     342 .. 0.83

  Alignments for each domain:
  == domain 1  score: 61.4 bits;  conditional E-value: 1.3e-20
                 -TTTH--.SSEEEETTT--EEE-TTTT-HHHHHHHHH---EEEETTT--EEETTTTEEBE-GC CS
      zf-UBP   1 CseCnsenknlWlCLkCghvgCgrksnghalkHyeetrHplavdlstlsvycyscddevedke 63 
                 C +C+s+  ++W+CLkC  v C r++++h+l+Hye+t+H+l+++l + s+ycy+cd +ve+k+
  EFC39467.1  59 CRHCHST-AENWFCLKCQDVCCSRYQKSHMLHHYEKTGHALVLSLADHSLYCYECDAYVENKT 120
                 9****99.9**************************************************9986 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.6
                 ETTT--E CS
      zf-UBP  14 CLkCghv 20 
                 C kCgh+
  EFC39467.1 334 CDKCGHI 340
                 7789887 PP

>> Milton  Kinesin associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       1.4   8.6e+03      26      53 ..       4      31 ..       3      38 .. 0.79
   2 ?   10.5   0.0   8.2e-05      0.49      72     124 ..     136     189 ..     100     215 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.4
      Milton 26 sSssstPrssvyggdgssvsldnrtssi 53
                sS + +P  ++y+ +g + ++  +t + 
  EFC39467.1  4 SSDTNKPNNTCYEIAGVGFAVAPKTDCP 31
                6888899999999999888888888774 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 8.2e-05
      Milton  72 GvPGapGak.dLeaALrrLslrrenylserrffevereRkllalaagtysydee 124
                   PGa Ga  ++e+A+ +L +  e    e++  + e+e++++ la++ +s  +e
  EFC39467.1 136 EYPGANGASvEMEEAIEKLRNVSEAIEEEKKKVDSEKEKAFEILAEKIQSASDE 189
                 36*****8659**********************************555444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (471 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1399  (0.07803); expected 358.6 (0.02)
Passed bias filter:                      788  (0.0439511); expected 358.6 (0.02)
Passed Vit filter:                        66  (0.00368119); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.51
# Mc/sec: 2788.59
//
Query:       EFC39468.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.059   13.1   0.4       0.15   11.8   0.3    1.7  1  DDE_3     DDE superfamily endonuclease


Domain annotation for each model (and alignments):
>> DDE_3  DDE superfamily endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.3   8.4e-06      0.15     103     135 ..     129     164 ..     111     173 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 8.4e-06
       DDE_3 103 e....adrlellylPpySPelNpiEivwsklkrellk 135
                      ++ l+l+y+P+yS  lN ++++ ++l r++ +
  EFC39468.1 129 TqtiiWKPLVLHYFPSYSKSLN-VKNWMHILRRRFTH 164
                 155557889*************.69999999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       613  (0.0341904); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.35s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 1523.90
//
Query:       EFC39469.1  [L=854]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-58  197.5   0.1    5.1e-58  195.8   0.1    1.9  2  GTP_EFTU     Elongation factor Tu GTP binding domain
    3.3e-21   75.1   0.0    9.2e-21   73.7   0.0    1.9  1  EFG_C        Elongation factor G C-terminus
      6e-20   71.2   0.0    1.2e-19   70.2   0.0    1.5  1  EFG_IV       Elongation factor G, domain IV
    4.1e-13   49.2   0.0    8.9e-13   48.1   0.0    1.6  1  EFG_II       Elongation Factor G, domain II
    1.1e-10   41.8   0.0      3e-10   40.3   0.0    1.8  1  GTP_EFTU_D2  Elongation factor Tu domain 2
     0.0005   19.9   0.0     0.0011   18.8   0.0    1.5  1  RF3_C        Class II release factor RF3, C-terminal domain
     0.0075   16.3   0.1      0.017   15.2   0.1    1.6  1  MMR_HSR1     50S ribosome-binding GTPase
  ------ inclusion threshold ------
       0.13   12.8   0.1         30    5.1   0.0    2.5  2  MycE_N       MycE methyltransferase N-terminal


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  195.8   0.1   2.3e-61   5.1e-58       2     194 .]      18     340 ..      17     340 .. 0.90
   2 ?   -2.2   0.0       1.1   2.5e+03      42      60 ..     549     567 ..     529     581 .. 0.76

  Alignments for each domain:
  == domain 1  score: 195.8 bits;  conditional E-value: 2.3e-61
                 CEEEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHHHHHSTHCHSHHHHHHTSCSSCEEEEEE.....TTCSSEEEEEEEESSSGGGHHHHHHHHHT-S CS
    GTP_EFTU   2 rirnigiighvDhGKtTLtdrLlyktgaiskkgekaeeervlDtlkeErergiTiksaaisle.....ketkkylinliDtPGHvdFskevirglrvlD 95 
                 +irni+ii+hvDhGK+TLtd+L  ++g +++    a+e+rv+D  k+E e+giTiks+  s+      ke +++l+nliD+PGH+dFs+ev+++lr++D
  EFC39469.1  18 KIRNISIIAHVDHGKSTLTDQLALAAGLVDE--DAAGEKRVCDVDKNEIEKGITIKSTSLSMVlenpdKENDHHLVNLIDCPGHIDFSSEVSTALRITD 114
                 79*****************************..666778*************************999779999************************** PP

                 EEEEEEETTTBSTHHHHHHHHHHHHTTTEEEEEEESCGSTHHHHHHHHHHHHHHHHHH.........HHHHHHHHHTTT........TTEEEEEEBTTT CS
    GTP_EFTU  96 gavlvvdaveGvepqteevlrlalkegvpiivfiNKmDrlkaelkeiveevkqklsrk.........eeklekygekge........kevpvvfgSalk 177
                 gavl+vda+eG   qte+v+r+ l+e++++++fiNK+Drl++e++ + ee +q++ r          ++         +         +++++fgS++ 
  EFC39469.1 115 GAVLIVDAAEGCRGQTETVIRQSLQERIRPVLFINKVDRLIEEMQFTEEESYQNFLRIiesvnallsTY---------SdesvsvdpVDCNIAFGSGKM 204
                 *******************************************************88866665555422.........2334455556889******** PP

                 TBTHH.............................................................................................. CS
    GTP_EFTU 178 gegvk.............................................................................................. 182
                 g++++                                                                                              
  EFC39469.1 205 GWAFTleqfaqlyskkfklpvekvinklwgenyydhstkkfttepysstsgqqlkhtfcefilepifkifklvrehqissegilptdleniisalsipl 303
                 **9998899999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999 PP

                 .........................HHHHHHHHHSHH CS
    GTP_EFTU 183 .........................tllealvellps 194
                                          +l+++++++lps
  EFC39469.1 304 tkeekrkepkllaksimrkflpahkPLVQMIINHLPS 340
                 9999999999999999999999998899999999885 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.1
                 THCHSHHHHHHTSCSSCEE CS
    GTP_EFTU  42 vlDtlkeErergiTiksaa 60 
                  l +l+eE +rgi ik + 
  EFC39469.1 549 CLKNLEEEYARGIQIKKSP 567
                 478999*******999874 PP

>> EFG_C  Elongation factor G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.7   0.0   4.1e-24   9.2e-21       2      86 ..     733     818 ..     732     840 .. 0.97

  Alignments for each domain:
  == domain 1  score: 73.7 bits;  conditional E-value: 4.1e-24
                 EEEEEEEEEEEEECCCCCCHHHHHHHCT-EEEEEEEE..TTEEEEEEEEEGGG-TTHHHCHHHCTTTS-EEEEEEEEEEE--HHHH CS
       EFG_C   2 llEPivkveievpeeyvgkvisdlssrrGeiedmeqd.asgrviieaeiPlaeligfateLrslTkGegsfsmefsgYeevpgdkl 86 
                 l+EP++ ve+++p++++g v+s +s+rrG i+++e   ++  v i++++P+ e++g+ +eLr +T+G++  +++fs+++ ++ ++ 
  EFC39469.1 733 LVEPMYLVEVQCPQSVMGSVYSVISNRRGVIKSTEMViGTPLVSITGNLPVLESFGLTEELRGVTQGQAFPQCSFSHWKVMEDNVY 818
                 89**********************************999*****************************************999876 PP

>> EFG_IV  Elongation factor G, domain IV
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   70.2   0.0   5.5e-23   1.2e-19      12     120 ..     619     729 ..     613     730 .. 0.96

  Alignments for each domain:
  == domain 1  score: 70.2 bits;  conditional E-value: 5.5e-23
                 -CCHCCCCCCCHTSSSHCCCCCEEEECCTTTTSSEEEEE--STCCCHCCCCHHHHCCCCCCTTS-TTTS--EESEEEEEEEEE--T..TTC-HHHHHHH CS
      EFG_IV  12 pvkereeklkkqsggdgqyakvileiePleegsgnefvdetkggqvpkeyieavekGfqealkeGplagepvtdvkvtLldgslhe..vdsseaafkpa 108
                 ++++r+++l    ++d+   k i++++P+  +++n++v++tk + + +e++++v++ fq+   +G l++e +++v +++ d+ lh+  ++++++++ +a
  EFC39469.1 619 DQNKRAKILEIDFEWDPSITKRIWSFGPEADKGSNILVNATKSVDYINEIQQYVVTSFQQSSSSGGLCDEAMRGVLFKFNDCNLHAdsIHRGAGQILQA 717
                 5566999******************************************************************************************** PP

                 HCHHHHHHHHCC CS
      EFG_IV 109 arralkeallkA 120
                 ++r++ ++ l+A
  EFC39469.1 718 TSRVMTASQLRA 729
                 *******99888 PP

>> EFG_II  Elongation Factor G, domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.1   0.0     4e-16   8.9e-13       4      72 ..     495     562 ..     493     565 .. 0.93

  Alignments for each domain:
  == domain 1  score: 48.1 bits;  conditional E-value: 4e-16
      EFG_II   4 PvislaiepkskadedklskaLarlleEDptlrverdeeTketilsGmGelHleivverlkreykveve 72 
                 Pv+++ +ep++ ad  ++ + L+rl++ Dp l+ +++ ++++ il   GelHlei +++l++ey   ++
  EFC39469.1 495 PVVQMGVEPANPADLSRFVEGLKRLVQSDPLLECKQN-DSGQHILGTAGELHLEICLKNLEEEYARGIQ 562
                 9*********************************987.8************************976555 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.3   0.0   1.3e-13     3e-10       2      74 .]     400     476 ..     399     476 .. 0.95

  Alignments for each domain:
  == domain 1  score: 40.3 bits;  conditional E-value: 1.3e-13
                  EEEEEEEEESEEETTEEEEEEC.TCTTSEE......EEEEEEEEEEETEEESEEETTSEEEEEEEESSCCSGSSTTCEEE CS
  GTP_EFTU_D2   2 tvalgrvysGtlkkGdevrilg.ndtskke......ivtrissletfhededeavaganaGvivaikgledaiivGdtlt 74 
                  ++al+r++sG l    +vrilg n++   +       +t i++l+++ ++ +e +  a +G iv+i+gl++ ii+++tlt
   EFC39469.1 400 FIALARIFSGSLTQSTKVRILGpNYD---PiakkdvFHTSIQRLLVMVGKNTESITQASCGAIVGIVGLDKYIIKSCTLT 476
                  689*******************9987...6666999******************************************96 PP

>> RF3_C  Class II release factor RF3, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   4.8e-07    0.0011      12      86 ..     498     571 ..     491     603 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 4.8e-07
                 EEEEEESSGGGHHHHHHHHHHHHHCTSSEEEEET.TSS-EEEEESSTHHHHHHHHHHHHHH---EEEEE-S--EE CS
       RF3_C  12 farvrlkdplkrkqlrkgleqLaeEGavqvfkeeeageelilgaVGqLQfeVveeRlknEYgvevrleslpysla 86 
                  + v+ ++p    ++ +gl+ L +       k++ ++ + ilg+ G+L +e+  + l++EY   +++++ p  + 
  EFC39469.1 498 QMGVEPANPADLSRFVEGLKRLVQSDPLLECKQN-DSGQHILGTAGELHLEICLKNLEEEYARGIQIKKSPPVVT 571
                 566899999999************9998888887.7899**********************99999988774333 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.1   7.4e-06     0.017       2     112 ..      22     148 ..      21     150 .. 0.61

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 7.4e-06
                 EEEEESTTSSHHHHHHHHH.............TSTEEESSST...TSSSSEEEEEEE...ETTEE.......EEEEECGGCSSHHHHHHHHHHHHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinalt.............gekaivsdkp...gtTrdinegrvk...lkgke.......ielvDtpGliegaseekglgkaflale 74 
                 + i+ +   GKStL  +l              ++++ v +     g T++ +   +        +       ++l+D+pG i+       ++ ++    
  EFC39469.1  22 ISIIAHVDHGKSTLTDQLAlaaglvdedaageKRVCDVDKNEiekGITIKSTSLSMVlenP---DkendhhlVNLIDCPGHID-------FSSEVSTAL 110
                 667778889*********9666666655553222344433222338888887777764340...23445555********776.......566666656 PP

                 C.TSEEEEEEETTTTCSHHHHHHHHHHHHHTTSEEEEEE CS
    MMR_HSR1  75 e.adlillvvdaseeklkpldeeleelleeakkplilvl 112
                 + +d ++l+vda+ e+ + + e++ +   +++++ +l +
  EFC39469.1 111 RiTDGAVLIVDAA-EGCRGQTETVIRQSLQERIRPVLFI 148
                 657********88.5566665555544433333344444 PP

>> MycE_N  MycE methyltransferase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.0     0.013        30      33      82 ..       6      56 ..       4      69 .. 0.85
   2 ?    4.9   0.0     0.015        34      60      98 ..     104     145 ..      98     146 .. 0.88

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.013
      MycE_N 33 dElvfRadleelpvdevsvqlalsaggeelsvlvaVgkggpv.veagesaa 82
                +E++ R+ l+ ++  ++s+   + +g+ +l   +a+++g +   +age+  
  EFC39469.1  6 KEILERLLLDSNKIRNISIIAHVDHGKSTLTDQLALAAGLVDeDAAGEKRV 56
                69*************************************976666666554 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.015
      MycE_N  60 eelsvlvaVgkggpv...veagesaaaaatveqdleelvral 98 
                  e+s+ +++++g++    +++g  ++++ +++q+l+e +r +
  EFC39469.1 104 SEVSTALRITDGAVLivdAAEGCRGQTETVIRQSLQERIRPV 145
                 579999*******9887788899999999********99976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (854 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       687  (0.0383178); expected 358.6 (0.02)
Passed bias filter:                      599  (0.0334096); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.75u 0.30s 00:00:01.05 Elapsed: 00:00:00.48
# Mc/sec: 5365.79
//
Query:       EFC39470.1  [L=464]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00051   19.8   0.0    0.00086   19.0   0.0    1.3  1  Abhydrolase_1  alpha/beta hydrolase fold
     0.0079   16.4   3.8     0.0079   16.4   3.8    2.1  2  Popeye         Popeye protein conserved region
  ------ inclusion threshold ------
      0.012   14.9   0.0      0.019   14.2   0.0    1.3  1  Hydrolase_4    Serine aminopeptidase, S33
      0.033   12.9   0.0       0.06   12.0   0.0    1.3  1  Ndr            Ndr family
      0.077   13.5   0.0       0.35   11.3   0.0    2.1  2  Sperm_Ag_HE2   Sperm antigen HE2
        1.1    9.8   4.0         14    6.3   0.9    2.6  2  OAD_gamma      Oxaloacetate decarboxylase, gamma chain


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.0   2.9e-07   0.00086      16     133 ..     262     371 ..     255     382 .. 0.76

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 2.9e-07
                    GTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB.CHHSHHHHHHHHHHHHHHCTTSSEE.EEEETHHHHHHHHHHHHHGGGEEEEEEESECSSC CS
  Abhydrolase_1  16 waerglapaLakdgfdvillDlrGvgySspapacinddygtasvaddldrildalgddklt.lvGhSmGGmialayaaeyperVkalvllgaidpa 110
                    ++   ++++L   g + +++D +G gyS+     + +d +t     +++ +l + g + ++ +vG+  GG i   +a+e+pe Vk+l++l+  +p 
     EFC39470.1 262 YYD--IQRYLTALGRRSCIYDKPGLGYSDYLYKDQ-KDEST-----FYYNFLTSIGEKTPYvMVGWGGGGHIIYKFALEHPELVKSLTFLDVFPPG 349
                    444..566677779999999999999999888764.34444.....6789999999999999******************************6666 PP

                    CHHHHHHHHHHHHHHCHHCHHHH CS
  Abhydrolase_1 111 aslieaqrqqaksfpdffdgyaa 133
                    +++ +  +   ++ +++f++y +
     EFC39470.1 350 IEFTSM-KDLKNWSQEQFNTYKN 371
                    666554.4455556666666655 PP

>> Popeye  Popeye protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   1.9       2.1   6.1e+03      40      71 ..      42      73 ..      12      77 .. 0.64
   2 !   16.4   3.8   2.6e-06    0.0079      24      76 ..      93     144 ..      86     152 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.1
                xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      Popeye 40 lalwawlvvCaldiflWnlllvlinlaqllyl 71
                 a ++ +++    + lW ++l+ +  aq++y+
  EFC39470.1 42 TASYGPVYIVNQFVGLWLCVLLTFFSAQTVYI 73
                34455555555555677777777777777776 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 2.6e-06
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      Popeye  24 lgllvlrsllvlGflllalwawlvvCaldiflWnlllvlinlaqllyllyklr 76 
                 +++l++ ++lv  f+l++l++      +d+++W++l+++i+l+ ++ l+++ +
  EFC39470.1  93 VNILYFGVILVGSFILFVLYSRAG-TRPDAIVWTILIMIICLLNVIALICRWY 144
                 678999999999999999999876.59*********************99865 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   6.4e-06     0.019      13     103 ..     259     339 ..     254     371 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 6.4e-06
  Hydrolase_4  13 laehsgryaelaeaLaaqGfavyalDhrGhGrsegkrghvpsfddyvdDlaafvekvkeehpelplfllGhSmGGliallyllrypdkvag 103
                  +a     y ++ ++L+a G   +++D  G G s+    ++++ ++++  + +         +++p +++G   GG i  +++l++p+ v+ 
   EFC39470.1 259 YA----DYYDIQRYLTALGRRSCIYDKPGLGYSDYLYKDQKDESTFYYNFLTS------IGEKTPYVMVGWGGGGHIIYKFALEHPELVKS 339
                  44....4668999********************98888888888887666444......46778**********************96665 PP

>> Ndr  Ndr family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0     2e-05      0.06     103     134 ..     316     347 ..     310     374 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 2e-05
                 EEEETHHHHHHHHHHHHSGGGEEEEEEES--- CS
         Ndr 103 glGvgaGAyilarfalkhperveglvLinits 134
                  +G g G  i+ +fal+hpe+v++l  +++ +
  EFC39470.1 316 MVGWGGGGHIIYKFALEHPELVKSLTFLDVFP 347
                 5899*********************9988776 PP

>> Sperm_Ag_HE2  Sperm antigen HE2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.95   2.8e+03       3      25 ..      52      74 ..      50      83 .. 0.81
   2 ?   11.3   0.0   0.00012      0.35       2      32 ..     188     220 ..     187     240 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.95
  Sperm_Ag_HE2  3 psfvsLLLvaLLfpGsSrassvn 25
                   +fv L L +LL   s+++ +++
    EFC39470.1 52 NQFVGLWLCVLLTFFSAQTVYIE 74
                  68999******988777777775 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00012
  Sperm_Ag_HE2   2 lpsfvsLLLvaLLfpGsSrassvnhqateg..p 32 
                   l+ f+ L++  LL++GsS as++    ++g   
    EFC39470.1 188 LLRFIFLIFLGLLISGSSAASNIKNYPMKGklI 220
                   778999*****************9988887443 PP

>> OAD_gamma  Oxaloacetate decarboxylase, gamma chain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.1      0.03        91      13      37 ..     122     146 ..     121     158 .. 0.87
   2 ?    6.3   0.9    0.0048        14      15      36 ..     191     212 ..     180     219 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.03
   OAD_gamma  13 vVFvvLilLslvislfskiikkkak 37 
                 +V ++Li+++ +++++  i ++++ 
  EFC39470.1 122 IVWTILIMIICLLNVIALICRWYSS 146
                 8999***************999875 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0048
   OAD_gamma  15 FvvLilLslvislfskiikkka 36 
                 F++Li+L l+is  s+ ++ k+
  EFC39470.1 191 FIFLIFLGLLISGSSAASNIKN 212
                 9***********9999887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (464 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       881  (0.0491383); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.69u 0.34s 00:00:01.03 Elapsed: 00:00:00.52
# Mc/sec: 2663.96
//
Query:       EFC39471.1  [L=461]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (461 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.49
# Mc/sec: 2833.98
//
Query:       EFC39472.1  [L=447]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-32  113.1  10.5    1.1e-31  109.9  10.5    2.3  1  Glucan_synthase  1,3-beta-glucan synthase component


Domain annotation for each model (and alignments):
>> Glucan_synthase  1,3-beta-glucan synthase component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.9  10.5   5.9e-36   1.1e-31     112     476 ..     100     443 ..      35     447 .] 0.73

  Alignments for each domain:
  == domain 1  score: 109.9 bits;  conditional E-value: 5.9e-36
  Glucan_synthase 112 dlpfyliGfkssep.eytlrtriWaslrsqtLyrtvsGfmnYskalkllyrvenaslvellseesekleeeleelaerKfklv.vamqryakfk 203
                      ++ + +  fk ++  + + ++r   sl+ qt+y+tv+G+  ++k ++  y++ + +  + +s +   + ++ + l e+ f  +   m + +k++
       EFC39472.1 100 KFKWISDRFKLDTLnRTQDEIRKIMSLKEQTIYKTVKGLADFKKGMEDYYSILDCNEEDRISVNYYLCLQKYHGLDENYFPKIeEDMSEIQKKR 193
                      3333333455444303456799999**********************99998777767777777777777777777777754412343333332 PP

  Glucan_synthase 204 kee....kenaelllkaypelkiayldeeaeeeeeekeyysvLidgsseideengkrkekyrirLsGnpilGdGKsdnqnhaiiftRGeyiqvi 293
                       +     +++ + l  ++p ++  y ++ + ++  + e+  +  +  ++i  ++ k ++  +i+       G+GKs nq ++ +f +G y+  +
       EFC39472.1 194 IQSeidfTNEINELCMEFPFIRRIYEKQIS-DQFIKIEHLDSYFNN-CQIL-DSVKLQR--KIN---CKFYGEGKSMNQLNSAMFLKGKYMLSL 279
                      222000123333566666666655544433.233333333333333.3443.2222222..232...2468*********************** PP

  Glucan_synthase 294 DanqdnyleEclKirsvLaefeeleleskkpyaeeiekeeekepvailGaREyiFsenigvLgdiaagkEqtFgtlfaRtlaeiggklHYGHPD 387
                      D+n d y  E +K   +++e  + +                     i G R + ++  ++ +g+ +a  E  F+    +++  +g++lHYG  D
       EFC39472.1 280 DSNMDAYYFEGIKFPCLMQEVMNSK-----S--------------HIFGMRTHTYTAFTSQVGKNMACAEHVFVATCYKAMCLLGSRLHYGNAD 354
                      ******************9976655.....2..............499********************************************** PP

  Glucan_synthase 388 flnaifmttRGGvsKaqkglhlnEDiyaGmnallRgGrikHseYiqcGKGRDlGfgsilnFttKigaGmgEqlLsReyyylgtqlpldR 476
                      +l++ f++ +G  + a++ l+l+ED++ G  +l  gG i+ se +  GKGR+  +++   F tKi+ G + q  s   y l + lpl  
       EFC39472.1 355 ILDREFFIEKGLFADADRYLNLSEDVFLGKRCLKFGGIIRYSEGVTFGKGRETNLKESAGFYTKIAGGAAMQSSSSIEYELNSSLPLCM 443
                      *************************************************************************************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (447 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       622  (0.0346924); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 2506.12
//
Query:       EFC39473.1  [L=351]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-15   58.1   0.0    3.1e-15   56.9   0.0    1.7  2  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
    1.2e-09   38.6   0.0    3.2e-09   37.3   0.0    1.8  1  2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
  ------ inclusion threshold ------
      0.018   15.4   0.0      0.049   14.0   0.0    1.7  1  2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
      0.025   14.8   1.2      0.069   13.4   0.0    2.3  2  PhyH            Phytanoyl-CoA dioxygenase (PhyH)
          6    6.9  16.6         12    5.9  16.6    1.5  1  YL1             YL1 nuclear protein
        7.9    6.6   9.0        1.3    9.1   4.9    1.8  2  DUF4717         Domain of unknown function (DUF4717)


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       3.3   9.9e+03      54      70 ..      44      72 ..      13      91 .. 0.47
   2 !   56.9   0.0     1e-18   3.1e-15       5      95 ..     248     350 ..     244     351 .] 0.87

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 3.3
                    ..................---TT-EEEEE CS
  2OG-FeII_Oxy_3 54 k............eavkikpkkgrlvlFe 70
                    +            e++ ++  ++++++  
      EFC39473.1 44 EeyddedfgeeeyEEEVVEISENEMLALL 72
                    03333344444444444444555555544 PP

  == domain 2  score: 56.9 bits;  conditional E-value: 1e-18
                     EE.-TT-EEEEE-SS--....--TT.-.EEEEEEEEE.....E.T-B--EEE..................---TT-EEEEE-..B-TEEE--B.- CS
  2OG-FeII_Oxy_3   5 ry.gegqeykpHvDnfe....keegsgqrrltvllyLne.kes.eeGGelelyekdk........eavkikpkkgrlvlFesdellpHevlpvtk 84 
                      y  +g +y++H D+f     +e   +qr++t+lly+n+ +++  +GG+l+++ k +         ++ i p +grlvlF s+ l +Hev+   k
      EFC39473.1 248 LYkSHGTYYEKHRDSFPsngkDEGPLDQRKVTALLYMNTeWKDeSDGGQLKIFIKPEnaskhterTTKLINPTAGRLVLFLSGAL-DHEVMASFK 341
                     5756799*********999986666689************55559*******9988899***998899999***********988.6*****754 PP

                     SS-EEEEEEEE CS
  2OG-FeII_Oxy_3  85 ggeRlsltgwi 95 
                       +R++lt w+
      EFC39473.1 342 --DRVALTSWL 350
                     ..9*******7 PP

>> 2OG-FeII_Oxy_4  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.3   0.0   1.1e-12   3.2e-09       8      92 ..     252     350 ..     244     351 .] 0.72

  Alignments for each domain:
  == domain 1  score: 37.3 bits;  conditional E-value: 1.1e-12
  2OG-FeII_Oxy_4   8 kgdvllnHdDvle.........geRrvayilyleeeWk.eddGGaL.llsddeg......dvtksivPkwnqlvlFev.keshsvaevasvaeke 84 
                     +g+++ +H D++          ++R+v+ +ly+++eWk e+dGG+L  + + e+      + tk i P+ ++lvlF +   +h+v      + k+
      EFC39473.1 252 HGTYYEKHRDSFPsngkdegplDQRKVTALLYMNTEWKdESDGGQLkIFIKPENaskhteRTTKLINPTAGRLVLFLSgALDHEVMA----SFKD 342
                     678888888886334555555579*************83569****444544422222325799*************9444687776....4579 PP

  2OG-FeII_Oxy_4  85 RlsisgWf 92 
                     R++++ W+
      EFC39473.1 343 RVALTSWL 350
                     *******8 PP

>> 2OG-FeII_Oxy_5  Putative 2OG-Fe(II) oxygenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   1.6e-05     0.049      52      92 ..     302     342 ..     275     347 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.6e-05
  2OG-FeII_Oxy_5  52 parkeeakeenqslvdvkpkeGdlvlFPs.wlrHevlpnege 92 
                     ++ +++ k++++++  ++p++G+lvlF s  l+Hev+++  +
      EFC39473.1 302 KP-ENASKHTERTTKLINPTAGRLVLFLSgALDHEVMASFKD 342
                     33.3345567899999***********87579*****98665 PP

>> PhyH  Phytanoyl-CoA dioxygenase (PhyH)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.2      0.46   1.4e+03      29      67 ..      35      73 ..       7     110 .. 0.56
   2 ?   13.4   0.0   2.3e-05     0.069       3      68 ..     115     177 ..     113     263 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.46
                HHHCHTTCCSEEEEECEEESTTCCCEECCCHHCHHHHTT CS
        PhyH 29 ldralesgdkidfffeekaaadedglleksinkvghflh 67
                +d+a +++d+  +  + ++++ e++ +e s+n+   +l+
  EFC39473.1 35 NDDAEYEDDEEYDDEDFGEEEYEEEVVEISENEMLALLD 73
                233333333333333333333333333444444444444 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 2.3e-05
                 HHSEEEETTSS-HHHHHHHHHHHHHH.......HHHCHTTCCSEEEEECEEESTTCCCEECCCHHCHHHHTTH CS
        PhyH   3 edGylviegflsaeevealraeieal.......ldralesgdkidfffeekaaadedglleksinkvghflhp 68 
                  +Gy+v+++f++ e+ +++++ +++l       +        ++   +e +a++  +++   ++  v  +lhp
  EFC39473.1 115 NNGYVVVDNFIPFEQAQEIHDLAKKLshtfkpaC--------EMKMSYEDEAEDTFRDNT--ARSDVIRWLHP 177
                 69***********************955555553........444444444444433333..33333333343 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9  16.6     0.004        12      20      62 ..      19      62 ..       5      93 .. 0.68

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.004
                x....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..x RF
         YL1 20 e....edelellFaEeedDeefeseeeeeeeensDsdfdsdeedee..s 62
                +    +d   ++FaEe dD+e+e++ee   +  +D+df ++e +ee  +
  EFC39473.1 19 NkggeDDQPTTTFAEENDDAEYEDDEE---Y--DDEDFGEEEYEEEvvE 62
                14542444445***********97654...4..6788866666555442 PP

>> DUF4717  Domain of unknown function (DUF4717)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   4.9   0.00043       1.3       4      42 ..      39      77 ..      35      93 .. 0.86
   2 ?   -3.1   0.1       2.7   8.2e+03      11      21 ..     152     162 ..     148     171 .. 0.46

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00043
     DUF4717  4 eksqkekvsskdqgqeqfEEhFvaSSvGElwqvvdmaqq 42
                e + +e+   +d g+e++EE+ v  S  E++ ++d +q+
  EFC39473.1 39 EYEDDEEYDDEDFGEEEYEEEVVEISENEMLALLDQQQD 77
                56778999999************************8775 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 2.7
     DUF4717  11 vsskdqgqeqf 21 
                 +s +d+ ++ f
  EFC39473.1 152 MSYEDEAEDTF 162
                 33333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (351 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       840  (0.0468515); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 2076.61
//
Query:       EFC39474.1  [L=382]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.2e-13   49.5   0.0    1.7e-12   48.0   0.0    1.7  1  Radical_SAM  Radical SAM superfamily
    1.5e-06   28.1   0.1    5.4e-06   26.4   0.1    2.0  2  HemN_C       HemN C-terminal domain
  ------ inclusion threshold ------
      0.012   15.6   0.2      0.063   13.2   0.0    2.2  2  MarR         MarR family
       0.11   13.0   0.0       0.28   11.7   0.0    1.6  1  HTH_27       Winged helix DNA-binding domain


Domain annotation for each model (and alignments):
>> Radical_SAM  Radical SAM superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.0   0.0   3.9e-16   1.7e-12      47     151 ..      31     142 ..      20     148 .. 0.90

  Alignments for each domain:
  == domain 1  score: 48.0 bits;  conditional E-value: 3.9e-16
                  SEEEEEESSTGGGSTTHHHHHHHHHHTC......CCTEEEEEEECSSCHGHHHHHHHHHTT-SEEEEEEBSSSHHHHHHHHTCTSHHHHHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Radical_SAM  47 vkevilgggepllypdfvellerlakla......vpgiritvetngtlpdeeklerllelgvdrvslgleaaddekvlklmnrghtfeevlealeklr 138
                     v++ggg+p+   +++++    + l+      ++g++i++e+n+t ++  kl+ + ++g++rvs+g++++d+e +lk ++r h++e+ l+a++++r
   EFC39474.1  31 LVSVFFGGGTPSTMHPLAMEKIISHGLEmfgksrEDGVEISMEANPTSIEYGKLKDFHRAGINRVSIGVQSFDSE-CLKSLGREHSIEDALNAIDIAR 127
                  5679**********99999999999999***********************************************.********************** PP

                  HTTSET..EEEEEEE CS
                  xxxxxx..xxxxxxx RF
  Radical_SAM 139 eagikr..vvdrivg 151
                  +  +++  ++d ++g
   EFC39474.1 128 NTFGEDsiSIDLMFG 142
                  995555766666665 PP

>> HemN_C  HemN C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.3   5.7e+03      37      50 ..     200     213 ..     194     213 .. 0.85
   2 !   26.4   0.1   1.2e-09   5.4e-06       1      55 [.     298     355 ..     298     370 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.3
      HemN_C  37 llaaaleklqeqGL 50 
                 l+++++e++ ++GL
  EFC39474.1 200 LYEFTIEECKKHGL 213
                 57999*****9998 PP

  == domain 2  score: 26.4 bits;  conditional E-value: 1.2e-09
      HemN_C   1 lspedrleEeiilgLRl.reGldlaafeqrfgld.leell.aaaleklqeqGLLeldg 55 
                 l++e+++eE++++gLR+  eG++ + + + +++  +e+ll a+ +++l+++G+++l +
  EFC39474.1 298 LTEEQQIEELFMMGLRMpKEGVSESSLRAINPELsFEKLLnANMIKQLENHGYIKLIK 355
                 799**************************666558******************97643 PP

>> MarR  MarR family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.31   1.4e+03      15      35 ..     146     169 ..     136     170 .. 0.66
   2 ?   13.2   0.0   1.4e-05     0.063      36      59 .]     340     363 ..     335     363 .. 0.96

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.31
                 STTEEHH...HHHHHHTS-HHHHH CS
        MarR  15 qgplsvs...eLakklgvskstvt 35 
                 + +   +    Lak+l+++ s+++
  EFC39474.1 146 HKNNPSIwknSLAKALSLNLSHLS 169
                 44433333558*******999876 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 1.4e-05
                 HHHHHHHHTTSEEEEEETTSTTSE CS
        MarR  36 rvldrLekkGlieRskspeDrRev 59 
                 +++++Le +G+i+  k ++D+R+v
  EFC39474.1 340 NMIKQLENHGYIKLIKEENDKRIV 363
                 79********************97 PP

>> HTH_27  Winged helix DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   6.2e-05      0.28      15      59 ..     318     362 ..     301     365 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 6.2e-05
      HTH_27  15 rrrrkkladlcgrlnvedshisyslkkLtekGLvertgdeadrre 59 
                  + +++l+++   l +e+  +++++k+L+++G+++  + e d+r 
  EFC39474.1 318 GVSESSLRAINPELSFEKLLNANMIKQLENHGYIKLIKEENDKRI 362
                 56688999999***********************99999999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (382 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       517  (0.028836); expected 358.6 (0.02)
Passed bias filter:                      407  (0.0227007); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2405.41
//
Query:       EFC39475.1  [L=734]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.023   15.0   3.8      0.068   13.5   3.8    1.8  1  RGS           Regulator of G protein signaling domain
      0.037   14.2   0.2        0.2   11.9   0.2    2.3  1  Arylesterase  Arylesterase
        1.6    9.0   3.8        4.1    7.7   0.5    2.5  2  zf-AN1        AN1-like Zinc finger


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   3.8   1.1e-05     0.068       8      93 ..     585     670 ..     561     686 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.1e-05
                 SHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHH CS
         RGS   8 dqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrlekeqpsrklfeea 93 
                 +++   + +e++ +e s en + ++  e++k++++q   ++ ++++ + y+a +s  elni++++r++  + l++++ s+  + e+
  EFC39475.1 585 NSAFQIMMKEYCVKEMSLENYNCYMFLERLKEKTDQLIDLTVIQQLEKDYFALNSIYELNIPSNVRKSFYELLKQVEDSHAQLCEM 670
                 555666789************************555555566*****************************999986555444444 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.2   3.4e-05       0.2      23      60 ..     349     386 ..     340     397 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 3.4e-05
  Arylesterase  23 fllllemslqlawtavvYyspsevkvvasglssanGIn 60 
                    l ++ ++ + + + ++ ys ++v++++sg++   GI 
    EFC39475.1 349 LLPIIVFYFEIHFSIIIVYSCKNVRNAISGFILTGGIL 386
                   4668999*****************************95 PP

>> zf-AN1  AN1-like Zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.2     0.059   3.5e+02      12      22 ..      19      29 ..       3      30 .. 0.80
   2 ?    7.7   0.5   0.00068       4.1      12      26 ..     291     305 ..     283     310 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.059
      zf-AN1 12 lpfkCryCgkv 22
                ++f+C +C+++
  EFC39475.1 19 IVFTCGTCNGN 29
                34******986 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.00068
      zf-AN1  12 lpfkCryCgkvFClk 26 
                 l  +C  C++++C++
  EFC39475.1 291 LLPQCTACKNDYCEE 305
                 4569*********86 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (734 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1075  (0.0599587); expected 358.6 (0.02)
Passed bias filter:                      434  (0.0242066); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.54
# Mc/sec: 4078.85
//
Query:       EFC39476.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1387  (0.0773607); expected 358.6 (0.02)
Passed bias filter:                      497  (0.0277205); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 917.67
//
Query:       EFC39477.1  [L=299]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1020  (0.0568911); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1700.67
//
Query:       EFC39478.1  [L=302]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-11   43.8   0.1    2.1e-06   28.5   0.0    2.5  2  Rxt3      Histone deacetylation protein Rxt3
    3.5e-08   33.4   0.0    7.2e-08   32.4   0.0    1.4  1  LCCL      LCCL domain


Domain annotation for each model (and alignments):
>> Rxt3  Histone deacetylation protein Rxt3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5   0.0   2.4e-10   2.1e-06      16      45 ..      75     104 ..      61     108 .. 0.81
   2 !   13.0   0.0   1.5e-05      0.13      96     127 .]     110     141 ..     104     141 .. 0.90

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 2.4e-10
        Rxt3  16 eivarrelWGtdvYtdDSDvvaaliHsGfi 45 
                 +   +r+++Gtd+Y+d +D+++a+ H+G++
  EFC39478.1  75 KSKDNRKIFGTDIYSDSTDIILACQHMGLL 104
                 45679***********************98 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 1.5e-05
        Rxt3  96 pekkDlhvtlliLpkLekYastvrygikSRew 127
                 +++k + vt+li  + +kY++t+r++++SR+w
  EFC39478.1 110 SNSKGILVTVLIEKPPSKYEATFRNNVRSRSW 141
                 5678899************************* PP

>> LCCL  LCCL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.4   0.0     8e-12   7.2e-08      30      92 ..      76     144 ..      67     148 .. 0.91

  Alignments for each domain:
  == domain 1  score: 32.4 bits;  conditional E-value: 8e-12
                 -SSS--EESSSSEETTSBHHHHHHHHTSS......-TT-EEEEEEEE--B-S---EE-SS-EEE--S-B CS
        LCCL  30 kdekasvvGskvYssdSsICkAAihaGvi......dnkgglvvvtiveelkeykgskqngieSeslskk 92 
                 ++++ +++G+++Ys+++ I  A  h G++      ++kg lv+v i++  ++y+++ +n+++S s+++ 
  EFC39478.1  76 SKDNRKIFGTDIYSDSTDIILACQHMGLLqdlplsNSKGILVTVLIEKPPSKYEATFRNNVRSRSWTNI 144
                 455689****************************9999999**********************998875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (302 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       426  (0.0237604); expected 358.6 (0.02)
Passed bias filter:                      328  (0.0182944); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1861.36
//
Query:       EFC39479.1  [L=417]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.1e-25   87.0   0.7    1.5e-23   83.2   0.0    2.5  2  SEP          SEP domain
    5.8e-14   52.0   0.0    1.1e-13   51.2   0.0    1.5  1  UBX          UBX domain
      5e-12   45.4   0.7      1e-11   44.4   0.2    1.9  2  UBA_4        UBA-like domain
  ------ inclusion threshold ------
       0.04   13.6   0.0      0.083   12.5   0.0    1.6  1  TAP_C        TAP C-terminal domain
       0.12   12.6   0.6       0.38   11.0   0.0    2.0  2  Spore_GerAC  Spore germination B3/ GerAC like, C-terminal
        2.5    8.1   4.9         23    5.0   0.0    3.0  3  Inp1         Inheritance of peroxisomes protein 1
        4.3    7.0  14.3       0.81    9.3   4.8    2.1  2  DUF966       Domain of unknown function (DUF966)


Domain annotation for each model (and alignments):
>> SEP  SEP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1      0.16   4.1e+02      55      76 .]     183     204 ..     181     204 .. 0.81
   2 !   83.2   0.0   5.7e-27   1.5e-23       1      76 []     229     301 ..     229     301 .. 0.97

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.16
         SEP  55 rrneeykppkkpkfkaFsGsGr 76 
                 ++  ey+ + k+++  F+GsGr
  EFC39479.1 183 KTRSEYDDELKQNKPKFEGSGR 204
                 5678899988888888****96 PP

  == domain 2  score: 83.2 bits;  conditional E-value: 5.7e-27
         SEP   1 ltlwknGFsvdDGelrsyddpenaeflesikkGevPeelekvekgeevevnledrrneeykppkkpkfkaFsGsGr 76 
                 +t+w++GF+vdDG+lr yddp+n +f+e+i++G +P+el+  e+g ++ vnl +r+  ++ +++k +fkaF GsGr
  EFC39479.1 229 ITFWADGFTVDDGPLRLYDDPQNVQFMEAINRGFAPRELA--EPGVDIAVNLLNRKTDKWAEQPK-QFKAFVGSGR 301
                 8***************************************..9*******************987.69******96 PP

>> UBX  UBX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.2   0.0   4.1e-17   1.1e-13       3      80 ..     342     415 ..     340     416 .. 0.91

  Alignments for each domain:
  == domain 1  score: 51.2 bits;  conditional E-value: 4.1e-17
                 TSSEEEEEEEETTSTEEEEEEESSSBHHHHHHHHHHHCCCCCTSEEEEETTTTEEGGCCCCSBCCCCTTTSCEEEEEE CS
         UBX   3 aedatrlqiRlpdGsrlvrrFkksdtlesvyeyVdsklfekeepFqLltsfPrreltksdkktLsdlgllpnstlvle 80 
                 ++++t+lqiRl+dG rlv +F+ ++t+  +++++++    ++  F+++t+fP++ lt++   t++++ +l+ +t++++
  EFC39479.1 342 NKPTTSLQIRLADGGRLVGKFNLTHTIGHIRQFIRQSKPSAD--FDIMTQFPNKVLTDDH-LTIEEA-GLKGATIIQK 415
                 6899*****************************998876553..9**************8.******.9999999876 PP

>> UBA_4  UBA-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.4   0.2     4e-15     1e-11       2      41 ..       4      43 ..       3      45 .. 0.94
   2 ?   -3.8   0.0       4.9   1.2e+04       6      13 ..     292     299 ..     291     299 .. 0.84

  Alignments for each domain:
  == domain 1  score: 44.4 bits;  conditional E-value: 4e-15
       UBA_4  2 eliaqFqaiTGadeekArqlLeannWdLerAislyFdsge 41
                e i+qF+ iT++++ +A+++Le++++d e+Ai+ yF + e
  EFC39479.1  4 EVIEQFKTITNTNDSVAQFYLESAGGDFETAITNYFSNAE 43
                679*********************************9876 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 4.9
       UBA_4   6 qFqaiTGa 13 
                 qF+a+ G+
  EFC39479.1 292 QFKAFVGS 299
                 9***9985 PP

>> TAP_C  TAP C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   3.2e-05     0.083       2      36 ..       5      39 ..       4      46 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.2e-05
                HHHHHHHHH-B-HHHHHHHHSSTTT-HHHHHHHHH CS
       TAP_C  2 mvqafstqtgMnlewsqkcLeqnnWdyerAlqvFe 36
                 +++f t t+ n   +q +Le+++ d+e A+ ++ 
  EFC39479.1  5 VIEQFKTITNTNDSVAQFYLESAGGDFETAITNYF 39
                689****************************9975 PP

>> Spore_GerAC  Spore germination B3/ GerAC like, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1      0.85   2.2e+03      49      80 ..     179     216 ..     138     231 .. 0.59
   2 ?   11.0   0.0   0.00015      0.38      47      75 ..     324     352 ..     303     375 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.85
                  EEEEEE.EEEEEEE-SSSEEEEE......EEEEEEEEE CS
  Spore_GerAC  49 veissskskikvkiengkpsfdi......kiklegdie 80 
                   +  +++s+++ +++++kp+f+       + +++ +++
   EFC39479.1 179 ERGAKTRSEYDDELKQNKPKFEGsgrrlgNTEASSSLI 216
                  44556666677777777777764222222444444433 PP

  == domain 2  score: 11.0 bits;  conditional E-value: 0.00015
                  .EEEEEEE.EEEEEEE-SSSEEEEEEEEE CS
  Spore_GerAC  47 vsveissskskikvkiengkpsfdikikl 75 
                   ++++sss+s++kv+++n+kp+ +++i+l
   EFC39479.1 324 KTTVSSSSSSNLKVEVDNNKPTTSLQIRL 352
                  4678888999**************99987 PP

>> Inp1  Inheritance of peroxisomes protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.3      0.52   1.3e+03      23      47 ..      87     111 ..      62     117 .. 0.56
   2 ?    5.0   0.0    0.0091        23      33      73 ..     217     256 ..     195     259 .. 0.65
   3 ?    3.1   0.7     0.035        90      21      53 ..     311     343 ..     291     357 .. 0.62

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.52
        Inp1  23 sssssssaeasdvdsesessetllw 47 
                 s +ss+++++s+++s+s+s+++ ++
  EFC39479.1  87 SVPSSNQPTTSSTSSNSSSTSKKPV 111
                 3444444444444444443333343 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.0091
        Inp1  33 sdvdsesessetllwksktertiAkgpLeIyripqsvafLs 73 
                 + +++++e+  t+++   +  t+  gpL++y  pq+v+f++
  EFC39479.1 217 KAEEKKKEKEVTITFW-ADGFTVDDGPLRLYDDPQNVQFME 256
                 2222222222355554.5678999***************86 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.035
        Inp1  21 sssssssssaeasdvdsesessetllwkskter 53 
                 sssssssss++ ++++  s+ss++l ++++ ++
  EFC39479.1 311 SSSSSSSSSSSVPKTTVSSSSSSNLKVEVDNNK 343
                 344444444455555555555556666666554 PP

>> DUF966  Domain of unknown function (DUF966)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   4.8   0.00032      0.81     112     253 ..      93     223 ..      70     237 .. 0.62
   2 ?    3.0   2.0     0.026        68     110     141 ..     308     339 ..     276     356 .. 0.50

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00032
      DUF966 112 s.rsaeeasssssssevavseassesespesskarr.kssssaeleeykvykaeeeeeaaeegaadastqtddkrrrsretkketasrgvstedeeeek 208
                 + ++++++s sss+s++ v+++   +++ + ++ +     ++++ ++ + y + ++++ ++   a+ s   dd+++ + +  k+ ++rg +t+ e  ++
  EFC39479.1  93 QpTTSSTSSNSSSTSKKPVTSSGGGRKFASLRDYSGdDDDEKPNSKDNRYYAGGSRNSGQQIIGANDSDDDDDENHFADKVFKAAQERGAKTRSEYDDE 191
                 2123344444444555555555555555555554443455999*********99999999999999999999999999998888888888886666554 PP

      DUF966 209 eekestelsreeispppsssspseksssgktetlesLiradvski 253
                  ++++ + + +               + g+te   sLi+a+ +k 
  EFC39479.1 192 LKQNKPKFEGSG-------------RRLGNTEASSSLIKAEEKKK 223
                 433333333222.............22333344444444444433 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.026
      DUF966 110 pasrsaeeasssssssevavseassesespes 141
                 + s+s++++sssss ++++vs++ss++   e+
  EFC39479.1 308 SSSSSSSSSSSSSSVPKTTVSSSSSSNLKVEV 339
                 22233344444444445555544444433333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (417 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1280  (0.0713927); expected 358.6 (0.02)
Passed bias filter:                      573  (0.0319594); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.68u 0.36s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 2453.90
//
Query:       EFC39480.1  [L=355]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.3e-06   27.7   0.0    2.3e-06   27.7   0.0    2.7  3  NYN_YacP        YacP-like NYN domain
     0.0022   18.3   1.1      0.037   14.3   0.0    2.9  3  PIN_9           PIN like domain
  ------ inclusion threshold ------
      0.015   15.9   4.8      0.015   15.9   4.8    2.0  2  SPT6_acidic     Acidic N-terminal SPT6
      0.021   14.7   0.7      0.052   13.4   0.1    1.9  1  Helicase_RecD   Helicase
       0.76    9.8   4.1          1    9.4   1.3    2.5  2  Toprim_Crpt     C-terminal repeat of topoisomerase
        2.1    8.6   5.5        3.1    8.0   0.2    2.8  3  Minor_capsid_1  Minor capsid protein


Domain annotation for each model (and alignments):
>> NYN_YacP  YacP-like NYN domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0         1   3.1e+03      60      87 ..      10      36 ..       3      40 .. 0.72
   2 ?   -0.4   2.6      0.33   9.9e+02     145     160 ..     138     153 ..     107     169 .. 0.46
   3 !   27.7   0.0   7.6e-10   2.3e-06       1     120 [.     190     319 ..     190     329 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1
                T----T.T-EEEE--TT--HHHHHHHHH CS
    NYN_YacP 60 eeeekaeglevvytkegetADsvIeklv 87
                +  e++ g++  y  ++++ D++Ie+ +
  EFC39480.1 10 NASEPI-GIKLNYIMKKHDDDQIIEQSL 36
                334444.89999999999999*999865 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.33
                 HSGGGGHHHHHHHHHC CS
    NYN_YacP 145 kkkklekklskeelek 160
                 +++k e++l+k+e+++
  EFC39480.1 138 SERKAERELKKQERQE 153
                 2222222222222222 PP

  == domain 3  score: 27.7 bits;  conditional E-value: 7.6e-10
                 EEEEHHHHHHHSHHHHT--.HHHHHHHHHHHHHHH.HHHHHHH--E.......EEEEE-TTTS---TT----T.T-EEEE--TT-...-HHHHHHHHHH CS
    NYN_YacP   1 llvDGYNvigawpelkklkekesleaaRekLieel.anyqsfkgye.......vivVFDAqkvkgseeeeekaeglevvytkege...tADsvIeklva 88 
                 +++DG N+  ++++l+ l  k++ +++ e+L+ ++  +y++f++++       ++vVFDA +++ + ++++   g  vv ++++e    AD++  +l++
  EFC39480.1 190 IIIDGNNLFFQTSTLRGLILKSKKKHQVEELLVHMaKKYSQFSETTfnqklnlMHVVFDASSNQVNGTSND---GTFVVSSAKKEgftIADDMLVELAN 285
                 79**************998888777777776555415799998754222233378******9999999884...456777777653336*********9 PP

                 HC--TT..--EEEE---CSSCTGGGGCTEEEE-H CS
    NYN_YacP  89 elrkek..eevvVvTSDraeqlvvfgkGAlrlsa 120
                 +++ +    ++  vTSDr  +    + GA+++ +
  EFC39480.1 286 RQNIAGtlDSCLFVTSDRGLRERLKSIGAKCIKS 319
                 999877889*********************9977 PP

>> PIN_9  PIN like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.5       0.2     6e+02      48      81 ..     139     172 ..     125     182 .. 0.73
   2 ?   -1.8   0.0       1.3   3.8e+03      71      88 ..     212     229 ..     190     241 .. 0.64
   3 !   14.3   0.0   1.2e-05     0.037      74     111 ..     274     317 ..     262     318 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.2
       PIN_9  48 gkgkertaakvalsLaerceiveaeeekaDdail 81 
                 ++++er+  k  ++ ++r +  e+++ +aDd+il
  EFC39480.1 139 ERKAERELKKQERQEKRRFQNEESQKIHADDVIL 172
                 4445555555556667778888888899***997 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.3
       PIN_9  71 aeeekaDdailelakeld 88 
                 ++++++++ ++++ak++ 
  EFC39480.1 212 KKKHQVEELLVHMAKKYS 229
                 234557777777777665 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 1.2e-05
       PIN_9  74 ekaDdailelakeldaa......vlvTnDreLkkrllekgipvi 111
                   aDd+++ela++ ++a       +vT+Dr+L++rl++ g + i
  EFC39480.1 274 TIADDMLVELANRQNIAgtldscLFVTSDRGLRERLKSIGAKCI 317
                 459*******9987654222232789***********9998876 PP

>> SPT6_acidic  Acidic N-terminal SPT6
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.2       4.5   1.3e+04      33      33 ..      71      71 ..      48      93 .. 0.48
   2 ?   15.9   4.8   4.9e-06     0.015      20      80 ..     117     187 ..     107     191 .. 0.55

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 4.5
  SPT6_acidic 33 e 33
                  
   EFC39480.1 71 I 71
                 1 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 4.9e-06
  SPT6_acidic  20 FIvddd.......eeeeeeeese.e...eeekkrrkkkkkrre...eeedaLdedDldLieentgvkvkrkkkkf 80 
                  FIvd          ++ ++++se +   e +k++r++k+   +   ee++++  dD  L+ e tg+ +k +  ++
   EFC39480.1 117 FIVDFKirmkkskKDKVSNDKSErKaerELKKQERQEKR---RfqnEESQKIHADDVILVDESTGIASKMNP-EI 187
                  666655554443323333333332221122223333333...24435669***************9998753.55 PP

>> Helicase_RecD  Helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   1.7e-05     0.052      45     125 ..     120     206 ..      93     208 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.7e-05
  Helicase_RecD  45 flakglealglke...eekkkkaekaelrvrkqrieyiapdellklkeqadllvvDEAAaiplpllkkl....lekfkrvvlatTvhG 125
                     ++  +++ + ++    ++++kae+   ++++q+ + ++ +e +k + + d+++vDE+  i  ++  ++    +++++ ++ ++T+ G
     EFC39480.1 120 DFKIRMKKSKKDKvsnDKSERKAERELKKQERQEKRRFQNEESQKIH-ADDVILVDESTGIASKMNPEIsriiIDGNNLFFQTSTLRG 206
                    44444444443334424444444434444446666666667777755.68*******9999988754443334666666666777766 PP

>> Toprim_Crpt  C-terminal repeat of topoisomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   1.3   0.00034         1      28      45 ..      70      87 ..      60      93 .. 0.89
   2 ?   -0.7   0.0      0.49   1.5e+03      29      42 ..     201     214 ..     199     221 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00034
  Toprim_Crpt 28 ktgllkGFksKkgkkFdA 45
                 k+ ++k+Fk K+gkkF A
   EFC39480.1 70 KIVKVKDFKAKSGKKFRA 87
                 56679***********99 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.49
  Toprim_Crpt  29 tgllkGFksKkgkk 42 
                  t++l+G++ K++kk
   EFC39480.1 201 TSTLRGLILKSKKK 214
                  88899999888776 PP

>> Minor_capsid_1  Minor capsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0         2     6e+03      81      98 ..      67      84 ..      49      87 .. 0.64
   2 ?    2.5   0.3     0.056   1.7e+02      36      83 ..     149     197 ..     114     204 .. 0.66
   3 ?    8.0   0.2     0.001       3.1       6      47 ..     217     259 ..     212     271 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2
  Minor_capsid_1 81 keyiitkvipvyalsdei 98
                    k  +i kv+ ++a+s + 
      EFC39480.1 67 KSVKIVKVKDFKAKSGKK 84
                    455677777777777665 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.056
  Minor_capsid_1  36 idktvqvagrd.nskqkkknavifidkkysspliersvkdavvydGkey 83 
                      +++ +   ++ +s++ + + vi +d+        + + +++++dG+++
      EFC39480.1 149 QERQEKRRFQNeESQKIHADDVILVDESTGIASKMNPEISRIIIDGNNL 197
                     34444444444468888899999999999888888888999***99875 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.001
  Minor_capsid_1   6 idsviykkykeesdfgdpvyeeslvienvRid.ktvqvagrdn 47 
                     ++++ ++  k+ s+f++ +++++l + +v +d  ++qv+g++n
      EFC39480.1 217 VEELLVHMAKKYSQFSETTFNQKLNLMHVVFDaSSNQVNGTSN 259
                     6778888999**********************77888888873 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (355 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2135  (0.119081); expected 358.6 (0.02)
Passed bias filter:                      541  (0.0301746); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.45
# Mc/sec: 2352.44
//
Query:       EFC39481.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       423  (0.0235931); expected 358.6 (0.02)
Passed bias filter:                      284  (0.0158403); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.38u 0.20s 00:00:00.58 Elapsed: 00:00:00.37
# Mc/sec: 1381.80
//
Query:       EFC39482.1  [L=609]
Description: hypothetical protein NAEGRDRAFT_59262 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-11   42.3   0.3      0.011   15.3   0.0    4.2  4  Kelch_1   Kelch motif
    2.5e-10   40.2   0.3       0.25   11.4   0.0    5.9  5  Kelch_4   Galactose oxidase, central domain
    4.9e-07   29.9   1.4    0.00037   20.7   0.0    4.5  4  Kelch_3   Galactose oxidase, central domain
    9.9e-07   28.5   0.6       0.88    9.7   0.0    4.8  4  Kelch_2   Kelch motif
      3e-06   27.1   2.0        2.1    8.4   0.0    4.8  4  Kelch_5   Kelch motif
    0.00024   21.3   0.8          1    9.7   0.0    5.3  5  Kelch_6   Kelch motif


Domain annotation for each model (and alignments):
>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.79   2.3e+03      13      27 ..     174     189 ..     172     190 .. 0.76
   2 !   15.3   0.0   3.8e-06     0.011       3      40 ..     282     332 ..     281     334 .. 0.91
   3 !   13.0   0.1   1.9e-05     0.057       2      42 ..     423     475 ..     422     477 .. 0.96
   4 !    8.7   0.0   0.00042       1.3      23      42 ..     536     555 ..     503     557 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.79
                 EEEEEEEBCS.SSBEE CS
     Kelch_1  13 kiYviGGsdg.gnals 27 
                 ki  +GG+++ ++ ++
  EFC39482.1 174 KIVFFGGYFHeNQESN 189
                 67779***99777766 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 3.8e-06
                 BSEEEEEETTEEEEEEEBCS.............SSBEEEEEEEETTTTEEE CS
     Kelch_1   3 agagavvvggkiYviGGsdg.............gnalssvevyDpetntWr 40 
                 a++   +vg +iYv+GG+                +++s v+++D++ ++++
  EFC39482.1 282 ANHKILSVGKEIYVFGGHYMkwneltednqndaEKRTSFVYIFDTKRKKFE 332
                 6889999*******************9999999999999999999988776 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 1.9e-05
                 BBSEEEEEETTEEEEEEEBCS............SSBEEEEEEEETTTTEEEEE CS
     Kelch_1   2 ragagavvvggkiYviGGsdg............gnalssvevyDpetntWrel 42 
                 r g+ +v v+g  Y+ GG  +            + + +sv+ ++++t+++++l
  EFC39482.1 423 RFGHNVVNVNGVAYIYGGKLRkqynsgnpdqvnPHSDDSVYSFNFRTGQFSRL 475
                 789**********************************************9987 PP

  == domain 4  score: 8.7 bits;  conditional E-value: 0.00042
                 SSBEEEEEEEETTTTEEEEE CS
     Kelch_1  23 gnalssvevyDpetntWrel 42 
                  n+l++++v+D    +W+++
  EFC39482.1 536 TNFLDDCYVFDILRSEWSKV 555
                 689***************98 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.59   1.8e+03      13      22 ..     173     182 ..     159     190 .. 0.81
   2 !    5.5   0.0    0.0058        17      13      43 ..     291     333 ..     281     342 .. 0.81
   3 !    5.6   0.2    0.0052        16       2      45 ..     423     480 ..     422     484 .. 0.71
   4 !    9.0   0.0   0.00047       1.4       1      28 [.     485     513 ..     485     517 .. 0.77
   5 !   11.4   0.0   8.3e-05      0.25      25      47 ..     536     558 ..     528     562 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.59
     Kelch_4  13 gtiylfGGrg 22 
                  +i+ fGG+ 
  EFC39482.1 173 EKIVFFGGYF 182
                 57999***86 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0058
     Kelch_4  13 gtiylfGGrgedg............tllndlylldlstntWrr 43 
                  +iy+fGG + +             ++ + +y++d++ +++++
  EFC39482.1 291 KEIYVFGGHYMKWneltednqndaeKRTSFVYIFDTKRKKFEQ 333
                 6899999988764578888888999999999999999999875 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0052
     Kelch_4   2 RaghsatsipdgtiylfGGrgedg.........tllndl..ylldlstntWrrl....g 45 
                 R+gh ++ + +g  y++GG   +           +++d   y +++ t++++rl     
  EFC39482.1 423 RFGHNVVNV-NGVAYIYGGKLRKQynsgnpdqvNPHSDDsvYSFNFRTGQFSRLriksH 480
                 777888888.6888888887776666778888855555434889999999999866444 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00047
     Kelch_4   1 pRaghsatsipd.gtiylfGGrgedgtll 28 
                 pR++h+++ ip  + + + GG++   ++l
  EFC39482.1 485 PRMFHAMVEIPEnNCFLMMGGQNVTEQVL 513
                 9*********8835566688988766666 PP

  == domain 5  score: 11.4 bits;  conditional E-value: 8.3e-05
     Kelch_4  25 gtllndlylldlstntWrrlgsl 47 
                 + +l+d+y++d+   +W++++++
  EFC39482.1 536 TNFLDDCYVFDILRSEWSKVKQS 558
                 479****************9664 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.14   4.3e+02       2      18 ..     173     189 ..     172     206 .. 0.76
   2 ?   -0.4   0.3      0.53   1.6e+03       1       9 [.     290     298 ..     290     300 .. 0.87
   3 !   20.7   0.0   1.2e-07   0.00037       2      47 ..     433     492 ..     432     494 .. 0.81
   4 ?    2.2   0.0     0.081   2.4e+02      13      35 ..     534     556 ..     530     567 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.14
     Kelch_3   2 drlyifGGlgddgqdrl 18 
                 +++++fGG+   +q+++
  EFC39482.1 173 EKIVFFGGYFHENQESN 189
                 689*******8766666 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.53
     Kelch_3   1 gdrlyifGG 9  
                 g ++y+fGG
  EFC39482.1 290 GKEIYVFGG 298
                 5689****9 PP

  == domain 3  score: 20.7 bits;  conditional E-value: 1.2e-07
     Kelch_3   2 drlyifGGlgd....dgqdrl.......ndvyvydldtntWaei....aslppaRaghaat 47 
                 + +yi+GG+ +    +g +++        +vy++++ t+++ ++     + p +R++ha++
  EFC39482.1 433 GVAYIYGGKLRkqynSG-NPDqvnphsdDSVYSFNFRTGQFSRLriksHDKPHPRMFHAMV 492
                 679*******9999633.3334667779**************887777779********97 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.081
     Kelch_3  13 dgqdrlndvyvydldtntWaeia 35 
                   +++l d yv+d+ + +W ++ 
  EFC39482.1 534 EATNFLDDCYVFDILRSEWSKVK 556
                 567899********777777552 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.013        40      12      29 ..     173     192 ..     159     197 .. 0.74
   2 !    9.7   0.0   0.00029      0.88       4      43 ..     283     332 ..     280     337 .. 0.74
   3 !    6.5   0.1    0.0029       8.8       2      22 ..     423     452 ..     422     476 .. 0.69
   4 ?    1.9   0.0     0.083   2.5e+02      30      49 .]     540     559 ..     538     559 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.013
     Kelch_2  12 gkiyvvGGa..htdnpnlss 29 
                  ki+++GG+  +++++n++s
  EFC39482.1 173 EKIVFFGGYfhENQESNDKS 192
                 79*******88555555544 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00029
     Kelch_2   4 ghsssvpggkiyvvGGa.........htdnpnls.ssdvhvldlekhvWe 43 
                  h + ++g  iyv+GG+         +++n+ ++ +s v+++d++ +++e
  EFC39482.1 283 NHKILSVGKEIYVFGGHymkwnelteDNQNDAEKrTSFVYIFDTKRKKFE 332
                 677889999********888888888666666652566677777776665 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0029
     Kelch_2   2 rgghsssvpggkiyvvGGa.........ht 22 
                 r+gh ++ ++g  y++GG           +
  EFC39482.1 423 RFGHNVVNVNGVAYIYGGKlrkqynsgnPD 452
                 89****************777776555544 PP

  == domain 4  score: 1.9 bits;  conditional E-value: 0.083
     Kelch_2  30 sdvhvldlekhvWeevtplg 49 
                 +d +v+d    +W++v+++g
  EFC39482.1 540 DDCYVFDILRSEWSKVKQSG 559
                 67799***********9976 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.0   0.00071       2.1      14      33 ..     172     190 ..     157     193 .. 0.63
   2 !    5.8   0.0    0.0048        14       6      22 ..     282     298 ..     277     298 .. 0.84
   3 !    6.7   0.1    0.0025       7.4       5      28 ..     423     444 ..     419     454 .. 0.82
   4 ?    1.4   0.0      0.11   3.2e+02       2      24 ..     483     507 ..     483     547 .. 0.54

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00071
     Kelch_5  14 sekiYvyGGkvgrdgsvsdd 33 
                 +eki ++GG+ + +++ s+d
  EFC39482.1 172 KEKIVFFGGYFH-ENQESND 190
                 499********7.5555554 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0048
     Kelch_5   6 aghcavtvsekiYvyGG 22 
                 a+h +  v+ +iYv+GG
  EFC39482.1 282 ANHKILSVGKEIYVFGG 298
                 678888899*******9 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0025
     Kelch_5   5 RaghcavtvsekiYvyGGkvgrdg 28 
                 R+gh +v v++  Y+yGGk   ++
  EFC39482.1 423 RFGHNVVNVNGVAYIYGGKL--RK 444
                 899999999*********97..44 PP

  == domain 4  score: 1.4 bits;  conditional E-value: 0.11
     Kelch_5   2 PppRaghcavtvs..ekiYvyGGkv 24 
                 P pR+ h++v  +  +  +++GG +
  EFC39482.1 483 PHPRMFHAMVEIPenNCFLMMGGQN 507
                 5578888888774224477777776 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.37   1.1e+03      12      23 ..     173     184 ..     166     207 .. 0.74
   2 !    9.7   0.0   0.00035         1       2      42 ..     281     333 ..     280     344 .. 0.86
   3 ?    0.8   0.5      0.23   6.8e+02       4      22 ..     425     443 ..     422     486 .. 0.54
   4 ?   -0.6   0.0      0.61   1.8e+03       1      23 [.     485     509 ..     485     522 .. 0.70
   5 ?    1.9   0.0       0.1     3e+02      24      43 ..     536     555 ..     529     558 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.37
     Kelch_6  12 gkiYifGGytds 23 
                 +ki+ fGGy + 
  EFC39482.1 173 EKIVFFGGYFHE 184
                 799******885 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00035
     Kelch_6   2 raghslvsvggkiYifGGytds............spylnkvwvydpetksWeq 42 
                 +a h + svg  iY+fGG +              +++++ v+++d + k++eq
  EFC39482.1 281 HANHKILSVGKEIYVFGGHYMKwneltednqndaEKRTSFVYIFDTKRKKFEQ 333
                 678999************99888989988888888888888888888888886 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.23
     Kelch_6   4 ghslvsvggkiYifGGytd 22 
                 gh +v v+g  Yi+GG   
  EFC39482.1 425 GHNVVNVNGVAYIYGGKLR 443
                 5666666666677777543 PP

  == domain 4  score: -0.6 bits;  conditional E-value: 0.61
     Kelch_6   1 praghslvsvg..gkiYifGGytds 23 
                 pr++h++v +   + + ++GG++  
  EFC39482.1 485 PRMFHAMVEIPenNCFLMMGGQNVT 509
                 6889999774422589999**9975 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.1
     Kelch_6  24 spylnkvwvydpetksWeql 43 
                 +++l++ +v+d+    W+++
  EFC39482.1 536 TNFLDDCYVFDILRSEWSKV 555
                 67899************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (609 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       816  (0.0455129); expected 358.6 (0.02)
Passed bias filter:                      372  (0.0207485); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.43u 0.23s 00:00:00.66 Elapsed: 00:00:00.39
# Mc/sec: 4681.76
//
Query:       EFC39483.1  [L=186]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       962  (0.0536561); expected 358.6 (0.02)
Passed bias filter:                      401  (0.022366); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.49u 0.25s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 1267.98
//
Query:       EFC39484.1  [L=462]
Description: adenylate kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.8e-11   43.7   0.1    1.1e-10   41.8   0.1    2.2  1  ADK       Adenylate kinase
    1.1e-07   32.3   0.0      3e-07   31.0   0.0    1.8  1  AAA_17    AAA domain
     0.0093   16.5   0.0      0.024   15.2   0.0    1.9  1  ABC_tran  ABC transporter
  ------ inclusion threshold ------
      0.026   15.1   0.0      0.072   13.6   0.0    1.8  1  AAA_18    AAA domain


Domain annotation for each model (and alignments):
>> ADK  Adenylate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.8   0.1   2.5e-14   1.1e-10       1      94 [.     111     197 ..     111     322 .. 0.88

  Alignments for each domain:
  == domain 1  score: 41.8 bits;  conditional E-value: 2.5e-14
                 EEESTTSSHHHHHHHHHHHHTSEE..EEHHHHHHHHHHCT-HHHHHHHHHHHTTSS--HHHHHHHHHHHHHCHGTTTEEEEESB-SSHHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         ADK   1 llGaPgaGKGtqaeklvkkyglah..lstGdllRaevksgtelGkeakevmdkgelvpdevvvklvkeelekedkkkgfllDGfPRtveqaealee 94 
                 l+GaPgaGKGt  + + ++ gl+   ++  dll +         +e+k++ d g+l++d  v++ v  +l +++ ++g ++DGfPRt  qa+ +  
  EFC39484.1 111 LVGAPGAGKGTMLKFINSQRGLTSkpITVSDLLNS---------EEMKKIKDSGRLISDAQVIEAVFTKLLDPEYENGVIVDGFPRTPVQAQCIAL 197
                 79**************9998765333999999965.........4789999****************************************97654 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.0   0.0   6.6e-11     3e-07       1     121 [.     112     242 ..     112     254 .. 0.65

  Alignments for each domain:
  == domain 1  score: 31.0 bits;  conditional E-value: 6.6e-11
                 EE-TTSSHHHHHHHHHHHHTEEE..EEHHHHHHHHHHTTTSHSSHHHHCTSHHHHHHHHHHHHHHHHHHHHHSSEEEEEE-SEEEETTEEEESSHHHHH CS
      AAA_17   1 lGgPGsGKgtqceklvekygfth..lsaGdllreeakrgglakardemrklpleekkelqkeaaekiaeeakkkgvlvdghprikeqagfldglpkevl 97 
                 +G PG+GKgt+++ +  + g+t   ++ +dll +e    +++k +d    + l  + ++ + +  k+ + + ++gv+vdg+pr+  qa+ ++ l + +l
  EFC39484.1 112 VGAPGAGKGTMLKFINSQRGLTSkpITVSDLLNSE----EMKKIKDS---GRLISDAQVIEAVFTKLLDPEYENGVIVDGFPRTPVQAQCIALLYDLML 203
                 7**************98777665459******866....44333443...456667788888888888888999**********999987665554443 PP

                 H...HH.............SEEEE.EE--HHHHHHHHHH CS
      AAA_17  98 e...elk...........pdaiil.leadpeeilerrlk 121
                 +   e++           p++ ++ l +d++  +er l+
  EFC39484.1 204 QfrhEFQsdsvvsqkfrrPSFRLCvLFVDEKISVERQLS 242
                 221222222222222223555444355555555555555 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   5.3e-06     0.024      10      51 ..     105     150 ..     103     293 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 5.3e-06
                 TTSEEEEEESTTSSHHHHHHHHTTSS--SEEEE....EETTCEGGG CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxx RF
    ABC_tran  10 egekvaivGenGaGKStLlkllagllkpteGei....lldgkdlke 51 
                 + e++ +vG  GaGK t+lk +  +   t+  i    ll+++++k+
  EFC39484.1 105 PKEIYWLVGAPGAGKGTMLKFINSQRGLTSKPItvsdLLNSEEMKK 150
                 67999******************99988888883333233333333 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   1.6e-05     0.072       3     113 ..     111     243 ..     110     256 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.6e-05
      AAA_18   3 ltGtpGvGKttlakeLskrlgf...gvnlrdvakenglllevdpealdeskrldedkldklldaleenssaleegknlvidghlaeleseaakdikk.. 96 
                 l G+pG+GK t+ k +++  g+    + ++d++  +++    d       ++ d ++ ++++++l         ++ +++dg++  +++++ + + +  
  EFC39484.1 111 LVGAPGAGKGTMLKFINSQRGLtskPITVSDLLNSEEMKKIKDSG----RLISDAQVIEAVFTKLLDPEY----ENGVIVDGFPRTPVQAQCIALLYdl 201
                 89**************88876666777777777777777777777....889999999999999999644....7777999999988877766555555 PP

      AAA_18  97 .........................vvLtaspeelleRlekR 113
                                           vL +++++  eR   R
  EFC39484.1 202 mlqfrhefqsdsvvsqkfrrpsfrlCVLFVDEKISVERQLSR 243
                 555555555555555555555555555555555555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (462 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.69u 0.36s 00:00:01.04 Elapsed: 00:00:00.55
# Mc/sec: 2519.74
//
Query:       EFC39485.1  [L=214]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       974  (0.0543254); expected 358.6 (0.02)
Passed bias filter:                      249  (0.0138881); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1308.72
//
Query:       EFC39486.1  [L=111]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.095   13.0   0.1       0.12   12.6   0.1    1.2  1  Retrotrans_gag  Retrotransposon gag protein


Domain annotation for each model (and alignments):
>> Retrotrans_gag  Retrotransposon gag protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   6.8e-06      0.12      22      57 ..      54      90 ..      40     104 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6.8e-06
  Retrotrans_gag 22 sidasesWkdlkkaflktflpserkdq.leeelsslr 57
                    + ++++s+++lk++fl+ f ps ++++  ++e+  ++
      EFC39486.1 54 RLYEIDSYDKLKQEFLDSFKPSTKSEEeIQREIEVIS 90
                    344499***************7766541455565555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (111 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1023  (0.0570584); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.38u 0.23s 00:00:00.61 Elapsed: 00:00:00.41
# Mc/sec: 806.75
//
Query:       EFC39487.1  [L=488]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.7e-26   92.6   0.0    2.8e-26   91.9   0.0    1.4  1  FAD_binding_4  FAD binding domain
    7.9e-07   29.1   1.2    1.6e-06   28.1   0.4    2.0  2  BBE            Berberine and berberine like


Domain annotation for each model (and alignments):
>> FAD_binding_4  FAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.9   0.0   3.1e-30   2.8e-26       1     138 [.      57     191 ..      57     192 .. 0.97

  Alignments for each domain:
  == domain 1  score: 91.9 bits;  conditional E-value: 3.1e-30
                    EEEEEEESSHHHHHHHHHHHHHCTSCEEEESSSTTEESTTCSCCEEEEEETTS--EEEEETTTTEEEEETTSBHHHHHHHHHHHTTECSSGGGTTC CS
  FAD_binding_4   1 paavvrpeseeevaaalrlaneaglpvlvrGgGssllgqavatggvvldlsrlnrileideeegtatveaGvtlgdlvealaakglllglepgsgi 96 
                    p+++ +++++e+v++++++a+e+ lp+++r+g +s+ g ++ ++ +++d+sr+++ +e+d ++  a+++aGv+  ++  al+ kgl++    g++ 
     EFC39487.1  57 PRVITYCKTVEHVRKCIAFAREHALPIRIRSGAHSYEGFSTGDEVMIIDVSRMKS-IELDMQKLEARIGAGVQNIEIFTALKDKGLIAV--GGACP 149
                    78999***********************************99999**********.8************************99999999..9**** PP

                    GSBHHHTTTTT-EETTEEGG--HHGTEEEEEEEETTSEEEEE CS
  FAD_binding_4  97 pgtvGGaiatnagGygsekyGlirdnvlglevvladGevvrl 138
                    +++v G++++++++  s+  Gl +d v ++e+v+ +G+++++
     EFC39487.1 150 TVGVCGFVMGGGWSFSSRYFGLGCDSVIEFEIVDYEGNLLTV 191
                    **************************************9987 PP

>> BBE  Berberine and berberine like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.2   1.1e+04      13      27 ..     413     428 ..     404     429 .. 0.68
   2 !   28.1   0.4   1.8e-10   1.6e-06       2      45 ..     443     488 .]     442     488 .] 0.92

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.2
                 HHHHHHHG.GGHHHHH CS
         BBE  13 ewgerYFg.gNferLv 27 
                 +w+++ +  +N e Lv
  EFC39487.1 413 QWEDEQYAkENKEWLV 428
                 6777666658887776 PP

  == domain 2  score: 28.1 bits;  conditional E-value: 1.8e-10
                 -TTS--GGG-HHHHHHHHG.GG..HHHHHHHHHHH-TT--S--TT-- CS
         BBE   2 YvNyrdldlgkewgerYFg.gN..ferLvkvKtkyDPdNvFrneqsI 45 
                 + N++ ++l+ ++ ++Y+g ++   e+L kvK +yDP  +F + q++
  EFC39487.1 443 FTNFPLIELK-DYRKQYYGrEEwrQEKLSKVKYQYDPLRIFSHSQGV 488
                 78********.********5547889*******************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (488 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.48
# Mc/sec: 3043.00
//
Query:       EFC39488.1  [L=426]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-38  127.5  31.3    0.00011   22.0   0.0   15.0 15  LRR_6     Leucine Rich repeat
    3.7e-32  109.9  22.2    8.1e-07   28.7   0.7    7.4  9  LRR_8     Leucine rich repeat
    1.2e-25   89.2  37.8     0.0014   19.0   0.4   10.6 13  LRR_4     Leucine Rich repeats (2 copies)
    4.1e-08   32.7  21.4        3.6    8.5   0.3   12.7 15  LRR_1     Leucine Rich Repeat
    7.7e-07   28.8  13.8      0.031   13.8   0.5    5.1  5  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
        1.8    8.9   7.2        2.6    8.4   0.1    4.1  5  DUF424    Protein of unknown function (DUF424)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.0     0.082   2.4e+02       5      23 ..      34      53 ..      32      54 .. 0.84
   2 !    6.8   0.0    0.0027       7.9       3      23 ..      81     101 ..      79     102 .. 0.90
   3 !   16.2   0.0   2.5e-06    0.0075       5      24 .]     107     126 ..     104     126 .. 0.92
   4 !    9.0   0.0   0.00052       1.6       5      23 ..     131     149 ..     128     150 .. 0.91
   5 !   13.8   0.0   1.6e-05     0.046       5      23 ..     155     173 ..     152     174 .. 0.91
   6 !   12.0   0.0   5.8e-05      0.17       5      21 ..     179     195 ..     176     198 .. 0.90
   7 ?    4.6   0.3     0.013        39       4      17 ..     202     215 ..     200     215 .. 0.91
   8 ?    1.4   0.1      0.14   4.3e+02       4      16 ..     225     237 ..     222     245 .. 0.85
   9 ?    4.5   0.2     0.015        44       5      17 ..     250     262 ..     248     262 .. 0.88
  10 !   17.4   0.1   1.1e-06    0.0032       7      24 .]     276     293 ..     271     293 .. 0.90
  11 !    5.4   0.0    0.0077        23       4      24 .]     297     317 ..     294     317 .. 0.89
  12 !   11.3   0.1   9.8e-05      0.29       4      21 ..     321     338 ..     320     341 .. 0.89
  13 !    8.0   0.0    0.0011       3.4       4      23 ..     345     364 ..     342     365 .. 0.85
  14 !   22.0   0.0   3.6e-08   0.00011       5      24 .]     370     389 ..     367     389 .. 0.94
  15 ?    0.3   0.1      0.32   9.7e+02       5      19 ..     394     408 ..     391     408 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.082
       LRR_6  5 LteLdLsgNd.IgDeGaeaL 23
                L++L+L  N  I  +G + +
  EFC39488.1 34 LKKLNLENNSnIHPSGFKYI 53
                89*******99998886666 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0027
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +Lt+L ++gN Ig eGa+ +
  EFC39488.1  81 KSLTYLLITGNYIGVEGAKYI 101
                 58****************977 PP

  == domain 3  score: 16.2 bits;  conditional E-value: 2.5e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+ L+++ N+Ig eGa+ ++
  EFC39488.1 107 LKQLHIANNNIGPEGAKHIS 126
                 99***************986 PP

  == domain 4  score: 9.0 bits;  conditional E-value: 0.00052
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L+++ N+I+ +Ga+ +
  EFC39488.1 131 LTILNIRANEITVDGAKFI 149
                 9***************977 PP

  == domain 5  score: 13.8 bits;  conditional E-value: 1.6e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++ gNdI DeGa+ +
  EFC39488.1 155 LTVLNIIGNDICDEGAKFI 173
                 9***************977 PP

  == domain 6  score: 12.0 bits;  conditional E-value: 5.8e-05
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt Ld+s N+Ig  Ga+
  EFC39488.1 179 LTNLDISVNNIGENGAK 195
                 9**************98 PP

  == domain 7  score: 4.6 bits;  conditional E-value: 0.013
       LRR_6   4 hLteLdLsgNdIgD 17 
                 ++t+L++ +N I+D
  EFC39488.1 202 NITKLNIGFNSIND 215
                 689*********98 PP

  == domain 8  score: 1.4 bits;  conditional E-value: 0.14
       LRR_6   4 hLteLdLsgNdIg 16 
                  Lt L++++ +Ig
  EFC39488.1 225 QLTDLNVNSSCIG 237
                 59*********98 PP

  == domain 9  score: 4.5 bits;  conditional E-value: 0.015
       LRR_6   5 LteLdLsgNdIgD 17 
                 Lt+L++++N I++
  EFC39488.1 250 LTHLSIASNSISN 262
                 9********9985 PP

  == domain 10  score: 17.4 bits;  conditional E-value: 1.1e-06
       LRR_6   7 eLdLsgNdIgDeGaeaLa 24 
                 +Ld+s+N IgD G+++++
  EFC39488.1 276 KLDISDNRIGDNGVQSIS 293
                 7**************996 PP

  == domain 11  score: 5.4 bits;  conditional E-value: 0.0077
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  LteL++s+ dI+  G++ ++
  EFC39488.1 297 QLTELNVSSIDITPIGIQYIC 317
                 69***********99999887 PP

  == domain 12  score: 11.3 bits;  conditional E-value: 9.8e-05
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                 +Lt+L +++N+Ig +Ga 
  EFC39488.1 321 NLTYLIIAHNNIGVKGAN 338
                 69**************95 PP

  == domain 13  score: 8.0 bits;  conditional E-value: 0.0011
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 hL  L++  N +gDeGa+ +
  EFC39488.1 345 HLAQLSIYNNAVGDEGAKFI 364
                 78888999999******977 PP

  == domain 14  score: 22.0 bits;  conditional E-value: 3.6e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L++ +N+IgDeG++aL+
  EFC39488.1 370 LTFLNIGSNEIGDEGVKALS 389
                 999***************96 PP

  == domain 15  score: 0.3 bits;  conditional E-value: 0.32
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 LteL+  +N+I+ eG
  EFC39488.1 394 LTELNTVDNNISEEG 408
                 89999999***9887 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.7   0.2   0.00011      0.34      22      56 ..      29      64 ..      14      69 .. 0.71
   2 !   25.1   0.1   3.7e-09   1.1e-05       2      61 .]      82     141 ..      81     141 .. 0.97
   3 !   27.1   0.3   8.9e-10   2.7e-06       2      61 .]     106     165 ..     105     165 .. 0.98
   4 !   27.1   0.3   8.4e-10   2.5e-06       2      61 .]     130     189 ..     129     189 .. 0.98
   5 !   20.7   0.5   8.9e-08   0.00027       2      58 ..     178     233 ..     177     236 .. 0.95
   6 !   28.7   0.7   2.7e-10   8.1e-07       2      58 ..     249     305 ..     248     308 .. 0.97
   7 !   19.2   0.6   2.6e-07   0.00076       2      60 ..     297     355 ..     296     356 .. 0.96
   8 !   20.7   0.4   8.8e-08   0.00026       2      61 .]     321     380 ..     320     380 .. 0.97
   9 !   14.7   0.1   6.6e-06      0.02      19      61 .]     362     404 ..     353     404 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00011
                TT-TT--EEE--SS---GGGGGGGT...T--S-.EEE- CS
       LRR_8 22 kglsnLkvLdLsnNllttlspgafs...gLpsLrsLdL 56
                 +++ Lk L+L nN  + ++p  f    +L++L+ L++
  EFC39488.1 29 DSMKELKKLNLENN--SNIHPSGFKyicSLEQLTDLYM 64
                6799**********..5666666651115666666655 PP

  == domain 2  score: 25.1 bits;  conditional E-value: 3.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L ++ N++ + + +    +++Lk L++ nN++    ++ +sgL++L+ L+++ N +
  EFC39488.1  82 SLTYLLITGNYIGVEGAKYIGEMKQLKQLHIANNNIGPEGAKHISGLEQLTILNIRANEI 141
                 79********************************************************86 PP

  == domain 3  score: 27.1 bits;  conditional E-value: 8.9e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L+ L++ nN++   + +  +gl++L++L+++ N++t+  ++ +s +++L+ L++ gN++
  EFC39488.1 106 QLKQLHIANNNIGPEGAKHISGLEQLTILNIRANEITVDGAKFISEMKQLTVLNIIGNDI 165
                 79********************************************************97 PP

  == domain 4  score: 27.1 bits;  conditional E-value: 8.4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+++ N +t+ + ++ + +++L+vL++  N +    ++ +sg+++L+ Ld+s N++
  EFC39488.1 130 QLTILNIRANEITVDGAKFISEMKQLTVLNIIGNDICDEGAKFISGMKQLTNLDISVNNI 189
                 79*******************************************************997 PP

  == domain 5  score: 20.7 bits;  conditional E-value: 8.9e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +Lt+Ld+s N++ + + +  + + n + L+++ N+++    ++f  +++L+ L++++
  EFC39488.1 178 QLTNLDISVNNIGENGAKYVSEMLNITKLNIGFNSINDC-VECFGKMKQLTDLNVNS 233
                 7*************************************8.49************976 PP

  == domain 6  score: 28.7 bits;  conditional E-value: 2.7e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 +Lt L++ +N++++ + +  ++++n+  Ld+s+N++     +++s +++L++L++s+
  EFC39488.1 249 QLTHLSIASNSISNYEASHISQMKNVIKLDISDNRIGDNGVQSISEMNQLTELNVSS 305
                 79****************************************************986 PP

  == domain 7  score: 19.2 bits;  conditional E-value: 2.6e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 +Lt+L++s+  +t ++ +   ++ nL++L + +N++ +  ++ +s +++L +L + +N 
  EFC39488.1 297 QLTELNVSSIDITPIGIQYICKMDNLTYLIIAHNNIGVKGANQISEMKHLAQLSIYNNA 355
                 79****************************************************99985 PP

  == domain 8  score: 20.7 bits;  conditional E-value: 8.8e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+L++ +N++ + +  + + +++L  L++ nN      ++ +s +++L++L++ +N +
  EFC39488.1 321 NLTYLIIAHNNIGVKGANQISEMKHLAQLSIYNNAVGDEGAKFISEMEQLTFLNIGSNEI 380
                 8*********************************************************86 PP

  == domain 9  score: 14.7 bits;  conditional E-value: 6.6e-06
                 TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++ + +++L+ L++++N++     +a+sg+++L++L+  +N++
  EFC39488.1 362 KFISEMEQLTFLNIGSNEIGDEGVKALSGMKQLTELNTVDNNI 404
                 4556699******************************999987 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.25   7.4e+02      15      29 ..       4      18 ..       1      27 [. 0.81
   2 !    8.2   2.5    0.0012       3.5      10      36 ..      18      45 ..       9      52 .. 0.72
   3 !    5.6   3.2    0.0077        23       2      33 ..      33      67 ..      32      94 .. 0.78
   4 !   12.3   0.0   5.8e-05      0.17       1      37 [.      81     118 ..      81     129 .. 0.81
   5 !   14.0   0.0   1.8e-05     0.053       2      39 ..     130     165 ..     129     168 .. 0.84
   6 !    6.1   0.1    0.0052        16      20      36 ..     174     189 ..     167     194 .. 0.71
   7 !   13.7   1.6   2.2e-05     0.065       1      37 [.     177     214 ..     177     219 .. 0.81
   8 !   12.5   0.8   5.1e-05      0.15       2      32 ..     202     233 ..     201     239 .. 0.85
   9 !    5.7   0.1    0.0069        21       2      16 ..     249     263 ..     235     273 .. 0.61
  10 !   16.3   0.6   3.3e-06    0.0098       2      38 ..     249     286 ..     248     287 .. 0.88
  11 !   19.0   0.4   4.5e-07    0.0014       1      41 [.     272     310 ..     272     313 .. 0.84
  12 !   12.2   0.0   6.2e-05      0.18       2      36 ..     321     356 ..     320     360 .. 0.75
  13 !   16.0   0.1   4.2e-06     0.012       2      34 ..     369     403 ..     368     416 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.25
                E-S-HHH-TT--EEE CS
       LRR_4 15 diplleklpnLkeLd 29
                 +p+le++ nL++++
  EFC39488.1  4 QLPFLENIANLRVIN 18
                5899999*****997 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.0012
                SS---.E-S-HHH-TT--EEE-.-S--- CS
       LRR_4 10 nNqlt.diplleklpnLkeLdLsgNnli 36
                nN +    + l +++ Lk+L+L +N++i
  EFC39488.1 18 NNEVGfNCEILDSMKELKKLNLENNSNI 45
                5566644444778*********888665 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0077
                S--EEE--SS.---.E-S-HH...H-TT--EEE-.-S CS
       LRR_4  2 nLevLdLsnN.qlt.diplle...klpnLkeLdLsgN 33
                 L++L+L nN ++  +  +++   +l +L+ L+++++
  EFC39488.1 33 ELKKLNLENNsNIHpS--GFKyicSLEQLTDLYMTFC 67
                7999999999889954..6554556888888888665 PP

  == domain 4  score: 12.3 bits;  conditional E-value: 5.8e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L + +N +   +   ++ +++Lk+L++  Nn+i+
  EFC39488.1  81 KSLTYLLITGNYIGVEGAkyIGEMKQLKQLHI-ANNNIG 118
                 689***********766675446*********.555664 PP

  == domain 5  score: 14.0 bits;  conditional E-value: 1.8e-05
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitdl 39 
                 +L++L+++ N +t +++  + + +++L++L++ gN    d+
  EFC39488.1 130 QLTILNIRANEIT-VDGakFISeMKQLTVLNIIGN----DI 165
                 79******88***.667675555*********999....76 PP

  == domain 6  score: 6.1 bits;  conditional E-value: 0.0052
                 HH-TT--EEE-.-S--- CS
       LRR_4  20 eklpnLkeLdLsgNnli 36 
                 +++++L+ Ld+s N +i
  EFC39488.1 174 SGMKQLTNLDISVN-NI 189
                 45888888888556.33 PP

  == domain 7  score: 13.7 bits;  conditional E-value: 2.2e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 ++L++Ld+s N++ + +    + + n ++L++ g+n i+
  EFC39488.1 177 KQLTNLDISVNNIGENGAkYVSeMLNITKLNI-GFNSIN 214
                 58*******99****99983344*********.555654 PP

  == domain 8  score: 12.5 bits;  conditional E-value: 5.1e-05
                 S--EEE--SS---E-S-.HHH-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpnLkeLdLsg 32 
                 n ++L+++ N + d    ++k+++L+ L++++
  EFC39488.1 202 NITKLNIGFNSINDCVEcFGKMKQLTDLNVNS 233
                 789**********77777999*********44 PP

  == domain 9  score: 5.7 bits;  conditional E-value: 0.0069
                 S--EEE--SS---E- CS
       LRR_4   2 nLevLdLsnNqltdi 16 
                 +L++L++++N ++  
  EFC39488.1 249 QLTHLSIASNSISNY 263
                 355555555555544 PP

  == domain 10  score: 16.3 bits;  conditional E-value: 3.3e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +L++L++++N ++  +   +++++n  +Ld+s+N +i+d
  EFC39488.1 249 QLTHLSIASNSISNYEAshISQMKNVIKLDISDN-RIGD 286
                 69************99976558*********999.7765 PP

  == domain 11  score: 19.0 bits;  conditional E-value: 4.5e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdlde 41 
                 +n ++Ld+s+N++ d +   ++ + +L+eL++s+     d+++
  EFC39488.1 272 KNVIKLDISDNRIGDNGVqsISEMNQLTELNVSSI----DITP 310
                 6999***********99985445*********886....7766 PP

  == domain 12  score: 12.2 bits;  conditional E-value: 6.2e-05
                 S--EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 nL++L +++N++  + +   ++ +++L +L++  Nn +
  EFC39488.1 321 NLTYLIIAHNNIG-VKGanqISEMKHLAQLSI-YNNAV 356
                 9*******99988.334244445*********.66655 PP

  == domain 13  score: 16.0 bits;  conditional E-value: 4.2e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 +L++L++++N + d +   l+++++L+eL+  +Nn
  EFC39488.1 369 QLTFLNIGSNEIGDEGVkaLSGMKQLTELNTVDNN 403
                 79************99999889********65773 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0         6   1.8e+04       1      10 [.      13      24 ..      13      27 .. 0.64
   2 !    8.5   0.3    0.0012       3.6       2      20 ..      34      50 ..      33      57 .. 0.82
   3 ?    0.4   0.0      0.54   1.6e+03       2      14 ..      59      74 ..      58      83 .. 0.65
   4 ?    0.1   0.0      0.67     2e+03       1      14 [.      82      95 ..      79     103 .. 0.78
   5 ?    2.9   0.0     0.083   2.5e+02       1      22 [.     106     127 ..     106     128 .. 0.77
   6 ?   -0.3   0.0      0.96   2.9e+03       2      13 ..     131     142 ..     130     151 .. 0.78
   7 ?    0.8   0.0      0.41   1.2e+03       1      18 [.     154     171 ..     154     176 .. 0.75
   8 ?    0.8   0.0      0.41   1.2e+03       2      12 ..     179     189 ..     178     199 .. 0.82
   9 ?    2.0   1.1      0.16   4.8e+02       1      13 [.     202     218 ..     202     246 .. 0.73
  10 ?    3.4   0.0     0.058   1.7e+02       1      20 [.     249     268 ..     249     271 .. 0.78
  11 ?    3.7   0.0     0.047   1.4e+02       3      21 ..     275     293 ..     273     295 .. 0.79
  12 ?   -0.8   0.0       1.4   4.2e+03       2      12 ..     298     308 ..     297     319 .. 0.69
  13 ?    3.5   0.0     0.052   1.5e+02       1      21 [.     321     341 ..     321     346 .. 0.87
  14 ?    3.8   0.0     0.043   1.3e+02       2      21 ..     370     389 ..     369     391 .. 0.83
  15 ?   -2.6   0.1       5.5   1.6e+04       2      12 ..     394     405 ..     393     410 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 6
       LRR_1  1 nLrhLd..Lsnn 10
                nLr+++  ++ n
  EFC39488.1 13 NLRVINneVGFN 24
                788887445555 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0012
       LRR_1  2 LrhLdLsnnpllglppnsf 20
                L++L+L+nn++  ++p+ f
  EFC39488.1 34 LKKLNLENNSN--IHPSGF 50
                9*********7..566555 PP

  == domain 3  score: 0.4 bits;  conditional E-value: 0.54
       LRR_1  2 LrhLdLsnnpl...lg 14
                L+ L+++ + +   + 
  EFC39488.1 59 LTDLYMTFCYFrlpIA 74
                88899****9844444 PP

  == domain 4  score: 0.1 bits;  conditional E-value: 0.67
       LRR_1  1 nLrhLdLsnnpllg 14
                +L++L +++n ++ 
  EFC39488.1 82 SLTYLLITGNYIGV 95
                5889999***9855 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.083
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 +L+ L++ nn+++  ++ ++++
  EFC39488.1 106 QLKQLHIANNNIGPEGAKHISG 127
                 5999******997666666665 PP

  == domain 6  score: -0.3 bits;  conditional E-value: 0.96
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L+++ n ++
  EFC39488.1 131 LTILNIRANEIT 142
                 999***999875 PP

  == domain 7  score: 0.8 bits;  conditional E-value: 0.41
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L++ +n + + ++ 
  EFC39488.1 154 QLTVLNIIGNDICDEGAK 171
                 599****99998766655 PP

  == domain 8  score: 0.8 bits;  conditional E-value: 0.41
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ Ld+s n++
  EFC39488.1 179 LTNLDISVNNI 189
                 899****9997 PP

  == domain 9  score: 2.0 bits;  conditional E-value: 0.16
       LRR_1   1 nLrhLdLsnnpl....l 13 
                 n ++L+++ n++    +
  EFC39488.1 202 NITKLNIGFNSIndcvE 218
                 67889999999833331 PP

  == domain 10  score: 3.4 bits;  conditional E-value: 0.058
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+hL + +n++++ +++++
  EFC39488.1 249 QLTHLSIASNSISNYEASHI 268
                 59*********976666655 PP

  == domain 11  score: 3.7 bits;  conditional E-value: 0.047
       LRR_1   3 rhLdLsnnpllglppnsfq 21 
                  +Ld+s+n++++ + +s++
  EFC39488.1 275 IKLDISDNRIGDNGVQSIS 293
                 68*******9887777765 PP

  == domain 12  score: -0.8 bits;  conditional E-value: 1.4
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L++s+  +
  EFC39488.1 298 LTELNVSSIDI 308
                 999**987655 PP

  == domain 13  score: 3.5 bits;  conditional E-value: 0.052
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++L + +n+++ +++n ++
  EFC39488.1 321 NLTYLIIAHNNIGVKGANQIS 341
                 8***********988888765 PP

  == domain 14  score: 3.8 bits;  conditional E-value: 0.043
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L++++n +++ +  +++
  EFC39488.1 370 LTFLNIGSNEIGDEGVKALS 389
                 999*******9988887776 PP

  == domain 15  score: -2.6 bits;  conditional E-value: 5.5
       LRR_1   2 LrhLd.Lsnnpl 12 
                 L++L+ + nn+ 
  EFC39488.1 394 LTELNtVDNNIS 405
                 889986677765 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.7     0.015        45      59     119 ..       4      63 ..       1      87 [. 0.76
   2 !    9.6   0.1   0.00019      0.58      63     128 ..     104     168 ..      95     184 .. 0.80
   3 !    6.9   0.4    0.0014         4      43     143 ..     178     275 ..     172     283 .. 0.66
   4 !   13.8   0.5     1e-05     0.031      47     127 ..     277     358 ..     270     374 .. 0.88
   5 ?    1.9   0.0     0.047   1.4e+02      86     128 ..     363     407 ..     356     417 .. 0.67

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.015
       LRR_9  59 gfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklells 119
                 ++P+l+ +  l + nn +   + ++ +++ +l++l l nn+  + + ++ + sl++l+ l 
  EFC39488.1   4 QLPFLENIANLRVINNEVGF-NCEILDSMKELKKLNLENNSNIHPSGFKYICSLEQLTDLY 63 
                 689*********99999865.5556677899999999999866666667777777766554 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00019
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk 128
                 +k+lk l ++nn i   + +    l +l+ l +  ne++  +  + + ++k+l++l ++ n ++++
  EFC39488.1 104 MKQLKQLHIANNNIGPEGAKHISGLEQLTILNIRANEITVDGA-KFISEMKQLTVLNIIGNDICDE 168
                 899*********9987777777777777777788888876555.8999*************99975 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0014
       LRR_9  43 qfdtidlsdndirkldg..fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviykl 139
                 q+  +d+s n+i +     +  +  +  l +  n i    e +++ + +l+ l ++++++  l+ +  + s+++l+ ls+ +n+++n        i ++
  EFC39488.1 178 QLTNLDISVNNIGENGAkyVSEMLNITKLNIGFNSINDCVECFGK-MKQLTDLNVNSSCIG-LCGIVFISSFNQLTHLSIASNSISNY---EASHISQM 271
                 555666666666653221123344455566666777666666665.567888888888875.9999*****************99874...44455555 PP

       LRR_9 140 kqlr 143
                 k++ 
  EFC39488.1 272 KNVI 275
                 5554 PP

  == domain 4  score: 13.8 bits;  conditional E-value: 1e-05
       LRR_9  47 idlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 +d+sdn i +  ++++  +++l  l +++  i+ i+ +    + nl+ l++++n++   +  + + ++k+l  ls+ +n+v +
  EFC39488.1 277 LDISDNRIGDngVQSISEMNQLTELNVSSIDITPIGIQYICKMDNLTYLIIAHNNIGVKGA-NQISEMKHLAQLSIYNNAVGD 358
                 689999996433899999**************************************97776.99***************9975 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.047
       LRR_9  86 vlPnleelvltnnelqelad..ldPlaslkklellsllknpvtnk 128
                 ++ ++e+l + n   +e++d  ++ l  +k+l+ l  ++n ++++
  EFC39488.1 363 FISEMEQLTFLNIGSNEIGDegVKALSGMKQLTELNTVDNNISEE 407
                 555566665555444444443369999999999999999999875 PP

>> DUF424  Protein of unknown function (DUF424)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       1.7   5.2e+03      45      58 ..      29      45 ..      13      47 .. 0.72
   2 ?   -0.4   0.0      0.47   1.4e+03      28      58 ..     109     136 ..     103     144 .. 0.74
   3 ?    8.4   0.1   0.00086       2.6      42      66 ..     144     168 ..     138     178 .. 0.86
   4 ?   -2.3   0.1       1.8   5.4e+03      27      54 ..     275     299 ..     248     306 .. 0.59
   5 ?    1.1   0.1      0.16   4.7e+02      29      63 ..     349     380 ..     342     407 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.7
                HHHHHHHHH...EEEEE CS
      DUF424 45 eaikeLeka...tiaNi 58
                +++keL+k+    ++Ni
  EFC39488.1 29 DSMKELKKLnleNNSNI 45
                68889998866666666 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.47
                 EEE--HHHH--EEE-HHHHHHHHHHHEEEEE CS
      DUF424  28 llnvsegfyggelaseeeaikeLekatiaNi 58 
                 +l++++  +g e a   + i+ Le++ti Ni
  EFC39488.1 109 QLHIANNNIGPEGA---KHISGLEQLTILNI 136
                 56666666666666...77889999999998 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.00086
                 -HHHHHHHHHHHEEEEEESHHHHHH CS
      DUF424  42 seeeaikeLekatiaNivgeeavvl 66 
                 + +++i+e++++t+ Ni+g++++++
  EFC39488.1 144 DGAKFISEMKQLTVLNIIGNDICDE 168
                 56789****************9986 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 1.8
                 EEEE--HHHH--EEE-HHHHHHHHHHHE CS
      DUF424  27 lllnvsegfyggelaseeeaikeLekat 54 
                 ++l +s   +g + +   ++i+e++++t
  EFC39488.1 275 IKLDISDNRIGDNGV---QSISEMNQLT 299
                 444455555555544...4555555554 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.16
                 EE--HHHH--EEE-HHHHHHHHHHHEEEEEESHHH CS
      DUF424  29 lnvsegfyggelaseeeaikeLekatiaNivgeea 63 
                 l++ +  +g e a   ++i+e+e++t  Ni  +e+
  EFC39488.1 349 LSIYNNAVGDEGA---KFISEMEQLTFLNIGSNEI 380
                 5666666666666...9999999999999965555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (426 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       618  (0.0344693); expected 358.6 (0.02)
Passed bias filter:                      336  (0.0187406); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.66u 0.35s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 2423.62
//
Query:       EFC39489.1  [L=182]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0017   18.4  21.1     0.0077   16.3  21.2    2.1  1  DUF3430   Protein of unknown function (DUF3430)
  ------ inclusion threshold ------
      0.084   13.1   1.1         11    6.3   0.1    3.0  3  DUF4841   Domain of unknown function (DUF4841)


Domain annotation for each model (and alignments):
>> DUF3430  Protein of unknown function (DUF3430)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3  21.2   8.5e-07    0.0077       1     144 [.       1     150 [.       1     159 [. 0.66

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 8.5e-07
     DUF3430   1 MKllfslilllllllnfl....insqyinfipyqsekCsgegsssgigysieideCitnd..........nqnnyvfsvftdssdgeiiktnyyedqnC 85 
                 MK ++  i+ll +    l    +n+q++    y+++kCs+          i +++C +n           ++++  +s+     ++++++ ++y d+ C
  EFC39489.1   1 MKAIILSIVLLAF----LaitsVNGQFLRSSVYTDSKCSSTLP--MLDLYIPSTNCTSNPnctgnnintlFTTSQCTSTVPSIGSKNTLQLSIYSDTTC 93 
                 8884444444333....33345*****************4444..55555555555555555555488877777777888888899999999999**** PP

     DUF3430  86 e.gkpistftfeigsCvstpefvn....nasnsssyysykvsttdepeiptnsvvtsfyngseC 144
                   g+ + ++ f  ++Cv  p++++     +++  +     +s +      +++v +s yng  C
  EFC39489.1  94 AsGNLVVSQIFPLDTCVVVPSVGSykstACRYLTV-----YSDSV-CTNVKQTVDFSAYNG-VC 150
                 *7777777**********99888833332222222.....22222.222456666666666.66 PP

>> DUF4841  Domain of unknown function (DUF4841)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.1    0.0012        11       4      19 ..      27      42 ..      25      52 .. 0.82
   2 ?    3.8   0.0    0.0075        68       4      19 ..      86     101 ..      84     108 .. 0.81
   3 ?   -0.8   0.0      0.21   1.8e+03       4      14 ..     127     137 ..     125     148 .. 0.77

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0012
     DUF4841  4 SiytDeaCseesllae 19
                S+ytD +Cs   ++++
  EFC39489.1 27 SVYTDSKCSSTLPMLD 42
                9********9888876 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.0075
     DUF4841   4 SiytDeaCseesllae 19 
                 Siy+D  C   +l++ 
  EFC39489.1  86 SIYSDTTCASGNLVVS 101
                 9*******88777665 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.21
     DUF4841   4 SiytDeaCsee 14 
                  +y+D  C++ 
  EFC39489.1 127 TVYSDSVCTNV 137
                 5899*999875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       585  (0.0326287); expected 358.6 (0.02)
Passed bias filter:                      271  (0.0151152); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.55
# Mc/sec: 998.17
//
Query:       EFC39490.1  [L=394]
Description: kinase C2 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-12   47.3   0.0    4.1e-12   46.3   0.0    1.6  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.3   0.0   2.3e-16   4.1e-12       3      91 ..      10     100 ..       8     113 .. 0.91

  Alignments for each domain:
  == domain 1  score: 46.3 bits;  conditional E-value: 2.3e-16
                 EEEEEEEEESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEE.EEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHH CS
          C2   3 levtvieAknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWn.ekftfevaeleeakLeveVfdndrlskddfiGkveiplstl 91 
                 l +t++++  Lp+ d  +s+d+y++v++     +  + kT+vi+++ nP+Wn   f+ +v+   ++ + +eV+d+d   kd+++ +v++pl +l
  EFC39490.1  10 LNLTIHSGYSLPKADLLSSIDAYCVVYVpllgGKLDIIKTKVIDDNANPTWNaALFRTDVDA--SRDMLIEVWDKDA-LKDEIVCRVNVPLPRL 100
                 899****************************99999*******9999*****6678888888..89999********.9***********9874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (394 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       533  (0.0297284); expected 358.6 (0.02)
Passed bias filter:                      412  (0.0229795); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2193.02
//
Query:       EFC39491.1  [L=276]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (276 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1728  (0.0963802); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1602.02
//
Query:       EFC39492.1  [L=182]
Description: rho GDP-dissociation inhibitor family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-53  181.1   0.2    2.1e-53  181.0   0.2    1.0  1  Rho_GDI   RHO protein GDP dissociation inhibitor


Domain annotation for each model (and alignments):
>> Rho_GDI  RHO protein GDP dissociation inhibitor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  181.0   0.2   1.2e-57   2.1e-53      22     195 .]       5     179 ..       1     179 [. 0.91

  Alignments for each domain:
  == domain 1  score: 181.0 bits;  conditional E-value: 1.2e-57
     Rho_GDI  22 qkslkeqleldkdDesLrryKeqLLgsakvdleavetnepe.vkilkltilsser..pdevleldltedleklkkkaftlkegseyklkisFkvsneiv 117
                 + s++++l++d +DesLr+yKeqLLg+a+  +   +t++p+ v++++  +  ++   pd+  e+d +e+  +l++++ ++keg++y + ++++v+++iv
  EFC39492.1   5 NESIDQILNKDTEDESLRKYKEQLLGAAAKGI--PKTDDPRrVVVETFGLRFPDGehPDIIREVDTKEKVATLENEPINIKEGVKYLFIVTYRVQHDIV 101
                 56999*********************977643..366666548888888888765116677789999999***************************** PP

     Rho_GDI 118 sGlkYvqtvwktgvkvdkskemlGsysPqqeeyeyeleeeeaPsGllarGsYsakskfvDDDkkvyleleysfeikkd 195
                   l++v+t++kt v+vd++++m+Gsy+P++e+y+y+ + + aPsG+larGs++a++kfvDDD k++le++ys+ ikkd
  EFC39492.1 102 PALHFVNTIKKTMVTVDQQNTMMGSYGPRAEPYTYKSQPQYAPSGMLARGSFKANTKFVDDDGKCHLEMNYSLVIKKD 179
                 *****************************************************************************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       434  (0.0242066); expected 358.6 (0.02)
Passed bias filter:                      359  (0.0200234); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.26s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1304.60
//
Query:       EFC39493.1  [L=186]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-47  160.6   0.0    2.7e-47  160.4   0.0    1.0  1  Ras       Ras family
    8.3e-18   64.7   0.0    1.3e-17   64.1   0.0    1.3  1  Roc       Ras of Complex, Roc, domain of DAPkinase
    8.2e-11   41.7   0.0    9.8e-11   41.4   0.0    1.1  1  Arf       ADP-ribosylation factor family


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  160.4   0.0   4.5e-51   2.7e-47       1     161 [.       7     171 ..       7     172 .. 0.98

  Alignments for each domain:
  == domain 1  score: 160.4 bits;  conditional E-value: 4.5e-51
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 K+v+vGd+avGKt+ll  +++++F+e+y +T+ +d+y++++++dg++vkle+wDT     +++lr+l+y +++++l++++  +++s+ n++ kw+ e++
  EFC39493.1   7 KIVVVGDGAVGKTCLLWVYANNSFPETYVPTV-FDNYKTTVSLDGRTVKLELWDTG---IYDRLRPLSYPGTQVFLICFSTVDETSYANIRtKWYPEVN 101
                 9*******************************.**********************5...7*******************************9******* PP

                 HHSTTTSEEEEEEETTTGGG.......G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee.......kravsteegeelakelg.lkfletSAktnenveeafeellreil 161
                 ++ +  vpivLvG+KvDl+e         ++s + ge+l  e++ +k++e+SAkt+++v+ +f+e++r++l
  EFC39493.1 102 HHSD-GVPIVLVGTKVDLREmgdksqgGDNISPQLGEKLKAEIKaIKYVECSAKTQQGVKMVFDEAIRAVL 171
                 ***9.7******************99999*************999**********************9875 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.1   0.0   2.1e-21   1.3e-17       1     120 []       7     118 ..       7     118 .. 0.84

  Alignments for each domain:
  == domain 1  score: 64.1 bits;  conditional E-value: 2.1e-21
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCH. CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenl. 95 
                 K+v+vGd++vGKt+ll  + +++f e++ +t+  +++t+ v +++g       ++vkl++WDt+    ++ l+pl + + +++++++    ++s++n+ 
  EFC39493.1   7 KIVVVGDGAVGKTCLLWVYANNSFPETYVPTVFDNYKTT-V-SLDG-------RTVKLELWDTGI---YDRLRPLSYPGTQVFLICFStvdETSYANIr 93 
                 9*******************************9998764.3.4544.......6799******95...5556677788888888887544377888883 PP

                 HHHHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  96 keWlkelkkvagkspvilvgnkiDl 120
                  +W+ e++++++  p++lvg+k+Dl
  EFC39493.1  94 TKWYPEVNHHSDGVPIVLVGTKVDL 118
                 58*********************95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.4   0.0   1.6e-14   9.8e-11      12     169 ..       3     164 ..       1     170 [. 0.83

  Alignments for each domain:
  == domain 1  score: 41.4 bits;  conditional E-value: 1.6e-14
                 TTEEEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEEEEE...TTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHH CS
         Arf  12 kkelrilllGLDnaGKtTilkklkleelvt.tvPTigfnveelei...knlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLka 106
                 +ke++i+++G  + GKt +l  + ++++ +  vPT+  n ++      +++k+++wD G  ++lRpl    ++ t++ + +  ++d++  ++ +++   
  EFC39493.1   3 SKEMKIVVVGDGAVGKTCLLWVYANNSFPEtYVPTVFDNYKTTVSldgRTVKLELWDTGIYDRLRPL---SYPGTQVFLICFSTVDETSYANIRTKWYP 98 
                 79********9999************9976379***99988633335599****************9...589*********************99998 PP

                 HCTSGCCTTSEEEEEEE-TTSTTSS-HH....HHHHHTTGGGSS.SSSSEEEEEEBTTTTBTHHHHHH CS
         Arf 107 lleeeelkevallvlaNKqDlpealsee....elrellgleelk.gkrkleiqkcsavkgeglkegle 169
                  ++++    v++++++ K Dl+e  +++    +++ +lg + lk   + ++ ++csa +++g+k  ++
  EFC39493.1  99 EVNHH-SDGVPIVLVGTKVDLREMGDKSqggdNISPQLGEK-LKaEIKAIKYVECSAKTQQGVKMVFD 164
                 88765.589************98776651111566666654.5525678999**********998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (186 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.46u 0.29s 00:00:00.75 Elapsed: 00:00:00.46
# Mc/sec: 1210.71
//
Query:       EFC39494.1  [L=168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       991  (0.0552736); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.47
# Mc/sec: 1082.34
//
Query:       EFC39495.1  [L=346]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.8e-25   88.3   0.2    5.8e-25   88.3   0.2    1.9  2  Band_7    SPFH domain / Band 7 family
     0.0097   15.4   0.8      0.017   14.7   0.8    1.3  1  LBP_M     Lacto-N-biose phosphorylase central domain
  ------ inclusion threshold ------
      0.011   15.4   0.2      0.011   15.4   0.2    1.7  2  Band_7_1  SPFH domain-Band 7 family
      0.038   13.8   9.9      0.062   13.1   9.9    1.4  1  DUF724    Protein of unknown function (DUF724)
       0.33   10.7   2.8       0.88    9.3   0.2    2.2  2  DUF5449   Family of unknown function (DUF5449)
       0.84    9.9   6.1        1.2    9.4   6.1    1.1  1  ICA69     Islet cell autoantigen ICA69, C-terminal domain


Domain annotation for each model (and alignments):
>> Band_7  SPFH domain / Band 7 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.3   0.2   1.9e-28   5.8e-25       2     176 ..      37     229 ..      36     233 .. 0.93
   2 ?   -1.8   0.5       0.9   2.7e+03     159     177 ..     254     272 ..     231     286 .. 0.61

  Alignments for each domain:
  == domain 1  score: 88.3 bits;  conditional E-value: 1.9e-28
      Band_7   2 iieegevgvvvrfGklsrvlepGlhfilPfgrsvtvvsvr.vqtldvsv......................sltvptkDglpvtidvtviyrvpddapk 77 
                 +++++ev +v+  Gk+sr+l  G+h+ lPf++sv+ v    +++ + ++                      +l+v tkD +++++++++ +++  ++ k
  EFC39495.1  37 TVSTNEVVLVEYLGKYSRTLTSGFHILLPFVESVKEVTWIrTIEDTLTRrtklstvrtgristsevmfdfpALDVSTKDRIIAKVNGIMFFKI-VNPYK 134
                 7999******99*****************9999994443335555555577777799999999999999999*********************.***** PP

      Band_7  78 lvaaveresanldnlirrvlesalrevisemtleellsnreelaeelknelneqlrkyGvevldvritdidpppevaqalaakqaaeaeaqaeiaraea 176
                 +v+++     +l + +++++  + r +is+ tl+e +++++ +++ + ++ +   + +Gv ++ ++i++i+ p+ +++++++   a++eaqae ++ +a
  EFC39495.1 135 AVYEI----SDLYQSMEQLVYTSMRDAISKITLDEAIEGKSTIKASIHEDFKGLENSWGVKLTKFDIQSIEAPESIQKSIEKLVSAQREAQAELEKTRA 229
                 *****....*************************************************************************************99987 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.9
      Band_7 159 akqaaeaeaqaeiaraeae 177
                 +++ +ea ++a++ +a+ae
  EFC39495.1 254 KRNIMEANTEAQVLKAKAE 272
                 4444444444444444433 PP

>> LBP_M  Lacto-N-biose phosphorylase central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.8   5.5e-06     0.017     123     199 ..     215     292 ..     204     307 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 5.5e-06
       LBP_M 123 Gvdkevgatlstdkynleaeekhfitedveeeldfg.eevkniyalegevevlaekdgevklavneyGkGrsvYlsgl 199
                   ++e +a+l++ +  +ea++ ++ te+  + l++  ++++ni   + e++vl++k+++ ++ +++ +k  ++Yl+ +
  EFC39495.1 215 SAQREAQAELEKTRALQEAKKLKIQTEQEIQLLECDaKNKRNIMEANTEAQVLKAKAESEAMNIEKMAKAEAIYLEKI 292
                 567899999999999999988777777666666665155699********************************9865 PP

>> Band_7_1  SPFH domain-Band 7 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.4   0.2   3.7e-06     0.011     128     208 ..     137     215 ..     110     218 .. 0.81
   2 ?   -3.0   0.2       1.7     5e+03     152     187 ..     242     280 ..     228     298 .. 0.51

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 3.7e-06
    Band_7_1 128 fdteeiseqlkslivtrlsdvlaeskipvldlaakseelaeklkealkeelaeyGlelekleienislpeevekaldkras 208
                 ++ +++ +++ +l+ t++ d+++  ki++ +    ++++ + ++e  k   ++ G++l+k+ i++i+ pe+++k ++k +s
  EFC39495.1 137 YEISDLYQSMEQLVYTSMRDAIS--KITLDEAIEGKSTIKASIHEDFKGLENSWGVKLTKFDIQSIEAPESIQKSIEKLVS 215
                 55667777888888888888875..566666666677888999999999889************************99776 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.7
    Band_7_1 152 skipvldlaaksee..l.aeklkealkeelaeyGlelek 187
                 ++i +l+ +ak+++  + a++ +++lk++ ++  +++ek
  EFC39495.1 242 QEIQLLECDAKNKRniMeANTEAQVLKAKAESEAMNIEK 280
                 445555554443321121222233344444444444444 PP

>> DUF724  Protein of unknown function (DUF724)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   9.9   2.1e-05     0.062      89     177 ..     205     295 ..     147     303 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 2.1e-05
      DUF724  89 alqsrlnkLlslkdeqtklleerkklekkieeeesekr..kleeeidelekkilelerqlallkekkeaadkeiarlkseaekleeeledv 177
                 ++q+ ++kL+s + e +  le++++l++  + + + ++  +l e  ++++++i+e ++++++lk+k e+++ +i ++ + ++ + e++ +v
  EFC39495.1 205 SIQKSIEKLVSAQREAQAELEKTRALQEAKKLKIQTEQeiQLLECDAKNKRNIMEANTEAQVLKAKAESEAMNIEKMAKAEAIYLEKILSV 295
                 578999*****99988888888777765544444444400444455699****************************99988877777766 PP

>> DUF5449  Family of unknown function (DUF5449)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   0.2   0.00029      0.88      19      79 ..     141     202 ..     128     231 .. 0.79
   2 ?    1.6   0.2     0.069   2.1e+02      32     103 ..     269     338 ..     239     342 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00029
     DUF5449  19 klltkvlkaaieklderisqiivndkdnskeilltsihkfykyaneel.tefkkesvkkvef 79 
                 +l++++ + +   + + is+i +++  ++k  + +sih+ +k  ++    +++k +++++e+
  EFC39495.1 141 DLYQSMEQLVYTSMRDAISKITLDEAIEGKSTIKASIHEDFKGLENSWgVKLTKFDIQSIEA 202
                 577887788888999************************99976664313455555555544 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.069
     DUF5449  32 lderisqiivndkdnskeilltsihkfykyaneeltefkkesvkkvefvkGtpdGkviiklkdgkelklddi 103
                  +     + +++  ++++i+l  i  +  +++e l  ++ke  k++e    + +   ii ++++k + ++++
  EFC39495.1 269 AKAESEAMNIEKMAKAEAIYLEKILSVKGISQEYL--LQKEYTKSIEHLAKSGNRTFIIPFESAKYFGMNNV 338
                 44445556688888999999999999999988876..68999999999999999999999999999888876 PP

>> ICA69  Islet cell autoantigen ICA69, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   6.1    0.0004       1.2      29     130 ..     204     302 ..     181     320 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0004
       ICA69  29 eeeeededeqlisLddekqakessekakedskkkkkevdekiskslsdkllseseselldlkeeeevakdl.lvdslegedaekddlsllneiLspssl 126
                 e+ ++  + +l+s + e qa+ ++ +a ++ kk k +++++i+  ++d  ++++++  +++++e +v k +  +++++ e+  k +  +l++iLs +  
  EFC39495.1 204 ESIQKSIE-KLVSAQREAQAELEKTRALQEAKKLKIQTEQEIQLLECD--AKNKRN-IMEANTEAQVLKAKaESEAMNIEKMAKAEAIYLEKILSVKGI 298
                 34444455.999999999888888877777777767766777766666..444455.678888888666551577999*****************9766 PP

       ICA69 127 eege 130
                 +++ 
  EFC39495.1 299 SQEY 302
                 6554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1595  (0.088962); expected 358.6 (0.02)
Passed bias filter:                      415  (0.0231469); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 2040.35
//
Query:       EFC39496.1  [L=2816]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
   4.6e-112  367.0 254.2    7.4e-12   45.9   8.3   25.1 26  Big_9       Bacterial Ig domain
    6.6e-66  218.9 172.4    6.6e-09   36.3   7.5   21.1 21  Cadherin_4  Bacterial cadherin-like domain
    1.8e-46  156.1 144.5    3.9e-09   36.4   2.1   21.9 23  Cadherin_5  Cadherin-like domain
    6.8e-20   72.0   1.3    2.2e-19   70.4   0.7    2.3  2  VWA         von Willebrand factor type A domain
    1.1e-09   38.8   0.7      5e-09   36.8   0.7    2.2  1  VWA_2       von Willebrand factor type A domain
     0.0063   16.5   7.7       0.18   11.8   0.2    6.6  7  Cadherin_3  Cadherin-like
  ------ inclusion threshold ------
       0.13   11.8   0.0       0.31   10.5   0.0    1.6  1  Spo0M       SpoOM protein


Domain annotation for each model (and alignments):
>> Big_9  Bacterial Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.6   0.1   6.2e-14   1.6e-10       4      88 ..      49     133 ..      46     135 .. 0.91
   2 !   33.4   0.2   2.2e-11   5.6e-08       4      88 ..     139     233 ..     136     235 .. 0.81
   3 !   40.6   5.4   1.3e-13   3.3e-10       6      88 ..     241     325 ..     237     326 .. 0.86
   4 !   23.9   5.0     2e-08   5.1e-05       6      88 ..     333     435 ..     328     437 .. 0.71
   5 !   37.3   3.6   1.4e-12   3.6e-09       4      87 ..     441     526 ..     438     529 .. 0.87
   6 !   15.8   3.5   6.9e-06     0.018       6      88 ..     543     626 ..     540     628 .. 0.71
   7 !   45.9   8.3   2.9e-15   7.4e-12       2      87 ..     632     722 ..     631     725 .. 0.80
   8 !   15.6   5.2   8.2e-06     0.021      32      88 ..     743     794 ..     727     795 .. 0.87
   9 !   18.2   1.4   1.2e-06    0.0032       7      88 ..     803     887 ..     799     888 .. 0.82
  10 !   37.9   1.4   8.7e-13   2.2e-09      10      88 ..     899     983 ..     890     985 .. 0.85
  11 ?   -0.7   0.1      0.99   2.5e+03      58      88 ..     990    1020 ..     984    1021 .. 0.75
  12 !   11.6   3.2   0.00014      0.36       2      88 ..    1027    1117 ..    1025    1119 .. 0.76
  13 !   18.7   5.0   8.7e-07    0.0022       2      88 ..    1121    1218 ..    1120    1220 .. 0.85
  14 !    7.9   2.0     0.002       5.2      30      86 ..    1258    1312 ..    1225    1316 .. 0.67
  15 !   12.2   1.6   9.1e-05      0.23      60      89 ..    1312    1342 ..    1308    1343 .. 0.81
  16 !   34.7   9.0   8.4e-12   2.2e-08       3      88 ..    1347    1436 ..    1345    1438 .. 0.81
  17 !   20.8   3.3   1.8e-07   0.00047       5      46 ..    1443    1490 ..    1439    1536 .. 0.80
  18 ?   -2.4   0.1       3.2   8.2e+03      32      78 ..    1574    1621 ..    1509    1627 .. 0.49
  19 !    6.6   1.4    0.0051        13      42      88 ..    1678    1727 ..    1661    1729 .. 0.72
  20 !   15.8   9.4   7.1e-06     0.018       3      74 ..    1730    1820 ..    1728    1836 .. 0.70
  21 !   23.1   4.7   3.6e-08   9.3e-05       5      89 ..    1841    1931 ..    1839    1932 .. 0.85
  22 ?    3.7   3.8     0.041   1.1e+02       8      88 ..    1940    2029 ..    1933    2031 .. 0.58
  23 !   18.3   1.6   1.1e-06    0.0029       5      88 ..    2037    2133 ..    2033    2134 .. 0.74
  24 !   18.7   2.2   8.6e-07    0.0022       2      48 ..    2141    2195 ..    2140    2244 .. 0.78
  25 ?   -2.2   0.1       2.8   7.2e+03      30      66 ..    2240    2275 ..    2198    2288 .. 0.66
  26 ?   -4.4   1.4         7   1.8e+04      25      70 ..    2726    2771 ..    2716    2787 .. 0.53

  Alignments for each domain:
  == domain 1  score: 41.6 bits;  conditional E-value: 6.2e-14
       Big_9   4 vtvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                 v + v +  ++P+ ++d +++ + ++     l nd+dp g +lt+       vt+p +G++++++ g + yt   +++g+d+f+Y+v++g
  EFC39496.1  49 VMISVGAGVQNPTLKPDYYELYKKTPsklypLLNDIDPRGGNLTIL-----NVTQPLHGKAVLSSAGMVIYTSIGSYAGNDTFEYSVTNG 133
                 55777778899***********99999999999*********9754.....579**********************************98 PP

  == domain 2  score: 33.4 bits;  conditional E-value: 2.2e-11
       Big_9   4 vtvtvtpvndaPvavddsvtvtedsv.............landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                   v  +  n+aP +vd ++tv+++s               a   d+dgd+l++t++      +p+ G++   +++ l ytp+ gf+  + ++Yt+sDg
  EFC39496.1 139 EHVYLSILNRAPEVVDMTYTVNKNSKknsfdlfgyesemGAKIKDIDGDDLSITDII---LVSPNVGSLISFDQNYLYYTPAYGFNNIELLNYTISDG 233
                 45555566**************7777777787777777677999********99874...456677777666677**********************9 PP

  == domain 3  score: 40.6 bits;  conditional E-value: 1.3e-13
       Big_9   6 vtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgt.ltytpna.gfsgtdsftYtvsDg 88 
                 +t++ +nd+P+a++d++t+t++ +     l+nd d++gd++++t     ++  ++ G v i++d++ + y p +  +  td f+Y ++Dg
  EFC39496.1 241 ITINVANDKPTAEPDTYTITKNALgtfniLDNDFDINGDNISIT-----TAGLGSSGVVLISSDNSnIEYIPKPfVAPYTDAFEYEITDG 325
                 777778**************888888999***********9754.....567889999999955545*******98999**********9 PP

  == domain 4  score: 23.9 bits;  conditional E-value: 2e-08
       Big_9   6 vtvtpvndaPvavddsvtvtedsv..landtdpdgdaltvtsltvtlvta...................panGtvtinadgt....ltytpnagfsgtd 79 
                 v v+ vn +P+++d  ++v+++s   l   t  d d l   ++t+t+v++                   p++  ++++   +    l+ytp++g   td
  EFC39496.1 333 VFVKIVNSPPTVSDKVFNVAKNSKnnLLDLTFSDPDVLD--TVTLTAVSKlargnsslsvtssmasvyyPTGDFLQVK---KnlysLVYTPDQGVIYTD 426
                 66888**************97777665544444445664..4666777775666666666666666666555555555...04456************* PP

       Big_9  80 sftYtvsDg 88 
                 sf+++vsDg
  EFC39496.1 427 SFKVKVSDG 435
                 ********9 PP

  == domain 5  score: 37.3 bits;  conditional E-value: 1.4e-12
       Big_9   4 vtvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsD 87 
                 +t+t++ v  +Pv v+d+vt ++++      ++nd  + gd l+   l+++++t+  +G+++  +d+++ y p++gf g+d+ +Y v +
  EFC39496.1 441 ATITINVVPSPPVPVNDTVTCQKNGQvsldvISNDYSASGDVLK---LNFASSTSNFGGKLVKIDDNNVKYEPAKGFLGQDEAQYIVIN 526
                 79999999*************855554777788**********7...67889999999999888899******************9866 PP

  == domain 6  score: 15.8 bits;  conditional E-value: 6.9e-06
       Big_9   6 vtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtin.adgtltytpnagfsgtdsftYtvsDg 88 
                 v v+ vn +Pvav+ ++tv+++ +     l    dp+gd+++++s+    + ++ + +++++ ++ ++ y + ++    d +++tv D 
  EFC39496.1 543 VLVNVVNSPPVAVPLTLTVSKGLTsalnlLRDSYDPNGDSINYNSI----AKSTYGVSLSFTsGNANVNYAALSS-VYVDYVDFTVVDI 626
                 668999*************944444455599*********987654....4444445555554466677766555.7777888888775 PP

  == domain 7  score: 45.9 bits;  conditional E-value: 2.9e-15
       Big_9   2 atvtvtvtpvndaPvavddsvtvtedsv....landtdpdgdaltvtsltvtlvtapanGtvtinadgt.ltytpnagfsgtdsftYtvsD 87 
                 + +t t++ vndaPv vdd++ v+ +      l+ ++d+dgd+l v+s+t  ++ + +  t+t  +dg  +t + ++++ g+dsft+ vsD
  EFC39496.1 632 QVATATINVVNDAPVPVDDTAAVSWNRIiipvLTYASDIDGDSLHVESFTQGSKGSVSRVTLTDGTDGLqFTTSGSNNYVGSDSFTFVVSD 722
                 5678888889**************77777777***************986655555555555555554256666777*************9 PP

  == domain 8  score: 15.6 bits;  conditional E-value: 8.2e-06
       Big_9  32 ndtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                 n td+d  +     +tv+++t ++ G+v+ +++ t+t+t n+g  g  ++t+t +Dg
  EFC39496.1 743 NVTDIDSQDS----VTVKDATVGSCGSVSKTSS-TVTFTSNKGSVGVCTVTITFTDG 794
                 8888887774....89*************9966.**********************8 PP

  == domain 9  score: 18.2 bits;  conditional E-value: 1.2e-06
       Big_9   7 tvtpvndaPvavddsvtvt..edsv......landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpna.gfsgtdsftYtvsDg 88 
                 +v+ +n+ P a++ s+tv+  +  +       ++ +d+d+dal+++   v ++  ++ G+ +in+d  l++t ++    gt ++ ++ +Dg
  EFC39496.1 803 NVNVQNQDPSAAPISTTVHwsK--SqaiidiMSTLSDADNDALSYS---V-SSYDSTFGSPSINSDKALVWTLPQtPKLGTTQIVISFTDG 887
                 78888*************9543..434778799**********854...3.456799***************7765778888888888887 PP

  == domain 10  score: 37.9 bits;  conditional E-value: 8.7e-13
       Big_9  10 pvndaPvavddsvtvt........edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDg 88 
                  +n aP+av+ +++ +        + + l+  +d dgd+l+++s t+ +vtapa+G+++i ++ ++ y  ++   g++s+tY+++Dg
  EFC39496.1 899 VQNVAPTAVAKTISSKwsaclsgiTIDILSECSDNDGDSLSFDS-TTPIVTAPAQGSASIVSS-KVYYKQSTASVGSYSITYKITDG 983
                 4699********6666555554447777***************9.788*************76.9*********************9 PP

  == domain 11  score: -0.7 bits;  conditional E-value: 0.99
       Big_9   58 tvtinadgtltytpnagfsgtd.sftYtvsDg 88  
                  ++t+n +  + yt  +  + +d +ftY++ Dg
  EFC39496.1  990 SITVNCT-FVKYTLKKPPTLSDkTFTYKAFDG 1020
                  5566633.688999988888888*****9998 PP

  == domain 12  score: 11.6 bits;  conditional E-value: 0.00014
       Big_9    2 atvtvtvtpvndaPvavddsvtvt....edsv....landtdpdgdaltvtsltvtlvtapanGtvtinadgt..ltytpnagfsgtdsftYtvsDg 88  
                  atvtv v ++  +P ++d+s+t +    +d+v     ++ td+dgd  +   l++ ++ ++a+ ++   ++g   + yt na f  tds ++  sDg
  EFC39496.1 1027 ATVTVKVVNA-NKPQISDQSTTAHwrtvKDGVsytvYDTLTDADGDYYS---LSF-GSGSSAYCSLIDLSNGIkgVKYTRNA-FDSTDSCKVVLSDG 1117
                  7888888855.56888888877774444444467556677888888775...556.5677889999999999999****876.899**********9 PP

  == domain 13  score: 18.7 bits;  conditional E-value: 8.7e-07
       Big_9    2 atvtvtvtpvndaPvavddsvtvt........edsvlandtdpdgdaltvtsltvtlvtapanGtvtin.adgtltytpna...gfsgtdsftYtvs 86  
                  + +t+t ++ n  Pva++ ++  +        + +vl+++td+d  +  + s+ +++ ++  +G+   n  +g++ y p++    + gtd++ Yt+s
  EFC39496.1 1121 SAATLTTNSYNNVPVAANFTLDYSggniqygiSIDVLSSATDADIQDVPFLSI-LSVGNSKLYGSEAANiVNGQVFYFPDQslvKALGTDTVAYTIS 1216
                  67899*************995555223335556677*************9997.88888999999888889*************9************ PP

       Big_9   87 Dg 88  
                  Dg
  EFC39496.1 1217 DG 1218
                  *9 PP

  == domain 14  score: 7.9 bits;  conditional E-value: 0.002
       Big_9   30 landtdpdgdaltvtsltvtlvtapanGtvtin..adgtltytpnagfsgtdsftYtvs 86  
                  l+   d+   +    + +v+++ + ++G+v+++  +  t+ty p+ ++ g++ f+  vs
  EFC39496.1 1258 LTKIADATKLD----TTVVQGSEPNQGGSVVVSsvDEKTVTYKPSGSYLGNEIFKLNVS 1312
                  55554444333....346788899999999998667888*************9998876 PP

  == domain 15  score: 12.2 bits;  conditional E-value: 9.1e-05
       Big_9   60 tina.dgtltytpnagfsgtdsftYtvsDgs 89  
                  ++++   ++t+t  ag   t +ftY vsDg+
  EFC39496.1 1312 SLSGdKKSFTFTNVAGNVATQTFTYVVSDGK 1342
                  44430447*********************96 PP

  == domain 16  score: 34.7 bits;  conditional E-value: 8.4e-12
       Big_9    3 tvtvtvtpvndaPvavdds.....vtvt...edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsg.tdsftYtvsDg 88  
                  + tvt++ +n aP a++ +     +tv+     ++l+  td dgd+l++ts+     t+++nG v+  ++ ++ y p++  +g t sftY+v Dg
  EFC39496.1 1347 SKTVTISITNNAPSATPITiskhwATVQgglDINLLSVVTDSDGDSLSITSF-----TQTNNGAVSSINSTSVKYIPTPLTAGfTTSFTYSVYDG 1436
                  557777777**********6666555555555555************99887.....78999999999899********7777266********9 PP

  == domain 17  score: 20.8 bits;  conditional E-value: 1.8e-07
       Big_9    5 tvtvtpvndaPvavddsvtvt.edsv.....landtdpdgdaltvtsl 46  
                  tvt++ +n++Pvavdd++tv+ ++++     + nd d d+d + +++l
  EFC39496.1 1443 TVTISITNTPPVAVDDTITVHwTNNTlylkpVVNDYDLDNDYIYINKL 1490
                  5566666*************8744445988888********9887765 PP

  == domain 18  score: -2.4 bits;  conditional E-value: 3.2
       Big_9   32 ndtdpdgdaltvtsltvtlvta....................panGtvtinadgtltytpnagfsgt 78  
                                       +                    ++ Gt+ ++++g + ++ +++ + +
  EFC39496.1 1574 DQ-------------------SfpssnvlsfspgvycfpqglSGSGTILLSGSGLYIFSISTNLNAN 1621
                  22...................1333333333333444444456777777777777777766665554 PP

  == domain 19  score: 6.6 bits;  conditional E-value: 0.0051
       Big_9   42 tvtsltvtlvta.panGtvtinadgtltytpna..gfsgtdsftYtvsDg 88  
                  +++s+t+ +v   +++  +++ +d   +y  n+  +   tdsf+Yt++D 
  EFC39496.1 1678 SLNSVTFGSVVIpTGQTALELQSDKLTVYYKNTfiNGPATDSFQYTITDQ 1727
                  455666655555144555677777666666666898899**********5 PP

  == domain 20  score: 15.8 bits;  conditional E-value: 7.1e-06
       Big_9    3 tvtvtvtp...vndaPvavdds.......vtvtedsvla.ndtdpdgdaltvtsltvtlvtapanGtvtin..adgtltytpna...........g 74  
                  t +v +     +n+aPva++ s        t+t+ sv++   +d+d d+l+     + +vt++++Gt t++  ++gt++ytp++            
  EFC39496.1 1730 TSNVAIVKlvfTNTAPVATSFSagkvtwkNTLTTASVVSkYCSDADKDSLS-----LFGVTQGKYGTTTVTdsTSGTIVYTPSSsisytsvdsngA 1820
                  555555556669********8887777766666677755589999999996.....447788888888777558899*****99665555544433 PP

  == domain 21  score: 23.1 bits;  conditional E-value: 3.6e-08
       Big_9    5 tvtvtpvndaPvavddsvtvtedsv.........landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDgs 89  
                  t+ v   n+aP  ++ s++v+ d++         l  +td++gd+++v+s++    ++ ++ +v ++++ t   t  +++ g+  f++t +Dg+
  EFC39496.1 1841 TFSVVVYNTAPKSASKSLSVQRDTSnptvtlndlLVGATDAEGDSISVSSVS--MISQNTGASVLLSSN-TAKLTYITSYLGSIVFSFTLTDGQ 1931
                  4556666**********9999888778888888799************9875..567888888888866.88888889**************96 PP

  == domain 22  score: 3.7 bits;  conditional E-value: 0.041
       Big_9    8 vtpvndaPvavddsvtvtedsv...........landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpna..gfsgtdsftYtvsDg 88  
                  vt +  +   vd ++++t+ds+           l++    d  +l      +++++  + G++  n+++ ltyt n+  + +g+   tY+ s+ 
  EFC39496.1 1940 VTITGAPFYCVDYTISTTKDSSavtfetdlkskLSSYCVNDVCTLA----LASTASLNGVGSIAANGNNLLTYTQNSksSSNGESYSTYSYSNR 2029
                  4433444445555566665555544443334444433333333333....23455668888888888888******988888998888887765 PP

  == domain 23  score: 18.3 bits;  conditional E-value: 1.1e-06
       Big_9    5 tvtvtpvndaPvavddsvtvt....edsv.........landtdpdgdaltvtsltvtlvta...panGtvtinadgtltytpnagfsgtdsftYtv 85  
                  ++ ++  n aP++ d +++ +    +            l++  dpd ++  ++  ++++v +   ++  +++i++d+++ +  n++f g+ sf+  v
  EFC39496.1 2037 KIIINQPNNAPTVYDYTYSYSisraS--NdyvtfdyvsLSSSDDPDASDS-IVLSSISSVGTcttSSISSLSITSDNQIKFLRNPSFIGSCSFSLVV 2130
                  688999*********99554432431..2445777777777778876664.4433444444467799999*************************** PP

       Big_9   86 sDg 88  
                  sD+
  EFC39496.1 2131 SDS 2133
                  **8 PP

  == domain 24  score: 18.7 bits;  conditional E-value: 8.6e-07
       Big_9    2 atvtvtvtpvndaPvavddsvtvtedsv........landtdpdgdaltvtsltv 48  
                   t+++t++++  +Pvav+d+v++t ++         l nd d  g + ++t ++ 
  EFC39496.1 2141 KTAKITINAISSPPVAVNDAVSTTYNTYidipvstlLGNDYDSLGGTFSFTGINC 2195
                  799*****************999955555555566699****9999988766544 PP

  == domain 25  score: -2.2 bits;  conditional E-value: 2.8
       Big_9   30 landtdpdgdaltvtsltvtlvtapanGtvtinadgt 66  
                  + +d+d    +  ++++++t  t + n  +++  dg+
  EFC39496.1 2240 IKSDSDSTTATA-IVTVSYTKCTCSLNMDIVFVLDGS 2275
                  445666555443.566677777767777766666666 PP

  == domain 26  score: -4.4 bits;  conditional E-value: 7
       Big_9   25 tedsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgt..ltyt 70  
                  te ++l n + p + + t+  +  t ++  a G+ t  +dgt   +yt
  EFC39496.1 2726 TEKTTLINNVLPYDESATF--FLGTKDSDIAVGSTTTWQDGTsmSSYT 2771
                  4555666666666666654..444555555556555555666443444 PP

>> Cadherin_4  Bacterial cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0     3e-06    0.0076       5      72 .]      51     114 ..      46     114 .. 0.90
   2 !   10.3   0.0   0.00033      0.84      11      62 ..     147     204 ..     137     219 .. 0.81
   3 !   36.3   7.5   2.6e-12   6.6e-09       4      69 ..     240     301 ..     238     303 .. 0.95
   4 !    9.6   0.6   0.00053       1.4       7      55 ..     335     380 ..     330     422 .. 0.81
   5 !   25.1   2.7   8.1e-09   2.1e-05       3      63 ..     441     499 ..     439     533 .. 0.77
   6 !   19.5   1.1   4.4e-07    0.0011       6      61 ..     544     595 ..     541     617 .. 0.87
   7 !   28.9   5.2   5.1e-10   1.3e-06       3      63 ..     634     689 ..     632     718 .. 0.83
   8 ?    1.8   2.4      0.15   3.8e+02      39      66 ..     743     777 ..     728     783 .. 0.71
   9 !   15.3   0.4   9.2e-06     0.024       6      67 ..     803     862 ..     800     866 .. 0.92
  10 !   14.7   0.2   1.4e-05     0.036      10      64 ..     900     957 ..     892     969 .. 0.88
  11 !    9.6   0.4   0.00054       1.4       3      59 ..    1027    1084 ..    1025    1095 .. 0.73
  12 !    8.9   2.1   0.00092       2.4       3      61 ..    1123    1184 ..    1121    1216 .. 0.77
  13 ?    0.4   0.3      0.39     1e+03      36      70 ..    1257    1301 ..    1224    1302 .. 0.62
  14 !   25.1   5.2   8.1e-09   2.1e-05       3      66 ..    1348    1410 ..    1346    1416 .. 0.82
  15 !   17.5   3.7   1.8e-06    0.0047       4      53 ..    1443    1490 ..    1441    1548 .. 0.73
  16 !   16.5   4.2   3.7e-06    0.0095      10      72 .]    1741    1804 ..    1729    1804 .. 0.82
  17 !   17.9   1.9   1.4e-06    0.0035       4      65 ..    1841    1905 ..    1838    1925 .. 0.80
  18 ?   -2.5   0.7       3.3   8.5e+03      16      68 ..    1949    2002 ..    1935    2008 .. 0.56
  19 !    6.6   1.0    0.0047        12       4      70 ..    2037    2112 ..    2034    2114 .. 0.65
  20 !   33.6   3.5   1.8e-11   4.6e-08       2      61 ..    2142    2207 ..    2141    2218 .. 0.84
  21 ?   -1.4   0.6       1.5   3.8e+03      24      71 ..    2726    2782 ..    2715    2787 .. 0.70

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 3e-06
  Cadherin_4   5 itvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlnadGsftY 72 
                 i+v +  ++P+ ++d ++    tp        l nd D+ g+ lt+  vt ++ +G  +l++ G + Y
  EFC39496.1  51 ISVGAGVQNPTLKPDYYELYKKTPSKL---YPLLNDIDPRGGNLTILNVT-QPLHGKAVLSSAGMVIY 114
                 66777778999999**********999...7889****************.***********998877 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00033
  Cadherin_4  11 ndaPvavddsatvtedtpltitagnvl.......andtDvdgddltvtavtv.agtyGtl 62 
                 n aP +vd ++tv+ ++  +    ++        a   D+dgddl++t + + +++ G+l
  EFC39496.1 147 NRAPEVVDMTYTVNKNSKKNSF--DLFgyesemgAKIKDIDGDDLSITDIILvSPNVGSL 204
                 99*************9998853..555666677699***********9875437777776 PP

  == domain 3  score: 36.3 bits;  conditional E-value: 2.6e-12
  Cadherin_4   4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlnadGs 69 
                  it++ +nd P+a++d++t+t ++  t+   n+l+nd D++gd +++t++   g+ G + +++d s
  EFC39496.1 240 VITINVANDKPTAEPDTYTITKNALGTF---NILDNDFDINGDNISITTAG-LGSSGVVLISSDNS 301
                 59**************************...*****************998.79*******99976 PP

  == domain 4  score: 9.6 bits;  conditional E-value: 0.00053
  Cadherin_4   7 vtgvndaPvavddsatvtedtpltitagnvlandtDvd.gddltvtavtv 55 
                 v  vn +P+++d +++v+ ++  +    ++  + +D+d  d++t tav+ 
  EFC39496.1 335 VKIVNSPPTVSDKVFNVAKNSKNNL--LDL--TFSDPDvLDTVTLTAVSK 380
                 889*******************999..466..688888567799999982 PP

  == domain 5  score: 25.1 bits;  conditional E-value: 8.1e-09
  Cadherin_4   3 vtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtv.agtyGtlt 63 
                 +tit++ v  +Pv v+d++t+  +++++    +v++nd+ + gd l  + ++  ++ +G l+
  EFC39496.1 441 ATITINVVPSPPVPVNDTVTCQKNGQVSL---DVISNDYSASGDVLKLNFASStSNFGGKLV 499
                 79***************************...9************66554443034445544 PP

  == domain 6  score: 19.5 bits;  conditional E-value: 4.4e-07
  Cadherin_4   6 tvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGt 61 
                  v+ vn +Pvav+ + tv  + +      n+l + +D++gd++ +++++   tyG 
  EFC39496.1 544 LVNVVNSPPVAVPLTLTVSKGLTSAL---NLLRDSYDPNGDSINYNSIA-KSTYGV 595
                 699******************99999...9******************9.888884 PP

  == domain 7  score: 28.9 bits;  conditional E-value: 5.1e-10
  Cadherin_4   3 vtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtlt 63 
                 +t t++ vndaPv vdd+a+v  +  +      vl+ ++D+dgd+l v ++t +g++G+++
  EFC39496.1 634 ATATINVVNDAPVPVDDTAAVSWNRIIIP----VLTYASDIDGDSLHVESFT-QGSKGSVS 689
                 5889999***************9998876....9*****************9.99999643 PP

  == domain 8  score: 1.8 bits;  conditional E-value: 0.15
  Cadherin_4  39 ndtDvdgdd.ltvtavt......vagtyGtltlna 66 
                 n tD+d++d +tv+ +t      v+ t  t+t+ +
  EFC39496.1 743 NVTDIDSQDsVTVKDATvgscgsVSKTSSTVTFTS 777
                 99****8888*****99333333344556777766 PP

  == domain 9  score: 15.3 bits;  conditional E-value: 9.2e-06
  Cadherin_4   6 tvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlnad 67 
                 +v+ +n++P a++ s tv    +  i   ++ ++ +D+d+d+l+++  + + t G+ ++n+d
  EFC39496.1 803 NVNVQNQDPSAAPISTTVHWSKSQAI--IDIMSTLSDADNDALSYSVSSYDSTFGSPSINSD 862
                 799***************99777776..49******************************98 PP

  == domain 10  score: 14.7 bits;  conditional E-value: 1.4e-05
  Cadherin_4  10 vndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavt...vagtyGtltl 64 
                 +n aP+av+ +++    + l++ + ++l+  +D dgd+l++ ++t   +a+++G+ ++
  EFC39496.1 900 QNVAPTAVAKTISSKWSACLSGITIDILSECSDNDGDSLSFDSTTpivTAPAQGSASI 957
                 799**********999888888778***************999987767999998876 PP

  == domain 11  score: 9.6 bits;  conditional E-value: 0.00054
  Cadherin_4    3 vtitvtgvn.daPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagty 59  
                  +t+tv  vn + P ++d+s t+   t   + + +v ++ tD+dgd  + +  +++ +y
  EFC39496.1 1027 ATVTVKVVNaNKPQISDQSTTAHWRTVKDGVSYTVYDTLTDADGDYYSLSFGSGSSAY 1084
                  4666666663469******9988877777777789**********9665555544555 PP

  == domain 12  score: 8.9 bits;  conditional E-value: 0.00092
  Cadherin_4    3 vtitvtgvndaPvavddsatvte...dtpltitagnvlandtDvdgdd...ltvtavtvagtyGt 61  
                  +t+t +  n+ Pva++ +        +  ++i   +vl+ +tD+d +d   l++ +v  +  yG+
  EFC39496.1 1123 ATLTTNSYNNVPVAANFTLDYSGgniQYGISI---DVLSSATDADIQDvpfLSILSVGNSKLYGS 1184
                  69999***********9986555111455556...9*********66558999999987888876 PP

  == domain 13  score: 0.4 bits;  conditional E-value: 0.39
  Cadherin_4   36 vlandtDvdgddltvtavtvagtyG..........tltlnadGsf 70  
                   l+   D+   d+tv++ +  +++G          t+t+ ++Gs+
  EFC39496.1 1257 PLTKIADATKLDTTVVQGSEPNQGGsvvvssvdekTVTYKPSGSY 1301
                  456667777777888888856666655555555555666666666 PP

  == domain 14  score: 25.1 bits;  conditional E-value: 8.1e-09
  Cadherin_4    3 vtitvtgvndaPvavddsat...vtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlna 66  
                   t+t+  +n+aP a++ +++   +t ++ l i   n+l+  tD dgd+l++t++t ++++G ++  +
  EFC39496.1 1348 KTVTISITNNAPSATPITISkhwATVQGGLDI---NLLSVVTDSDGDSLSITSFT-QTNNGAVSSIN 1410
                  58999999*********996444788888999...********************.89999887544 PP

  == domain 15  score: 17.5 bits;  conditional E-value: 1.8e-06
  Cadherin_4    4 titvtgvndaPvavddsatvte.dtpltitagnvlandtDvdgddltvtav 53  
                  t+t+  +n +Pvavdd++tv   +++l         nd+D d+d + ++ +
  EFC39496.1 1443 TVTISITNTPPVAVDDTITVHWtNNTLYL---KPVVNDYDLDNDYIYINKL 1490
                  7888889************9763555555...5678********9866654 PP

  == domain 16  score: 16.5 bits;  conditional E-value: 3.7e-06
  Cadherin_4   10 vndaPvavddsa.tvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlna..dGsftY 72  
                  +n aPva+  sa  vt  ++lt+ a  v    +D+d d+l+  +vt +g yGt t+ +  +G++ Y
  EFC39496.1 1741 TNTAPVATSFSAgKVTWKNTLTT-ASVVSKYCSDADKDSLSLFGVT-QGKYGTTTVTDstSGTIVY 1804
                  7*******987659999999998.46677779**************.*****97776534788877 PP

  == domain 17  score: 17.9 bits;  conditional E-value: 1.4e-06
  Cadherin_4    4 titvtgvndaPvavddsatvtedtpltita.gnvlandtDvdgddltvtavtv..agtyGtltln 65  
                  t++v   n aP  +  s +v  dt+  + +  ++l  +tD++gd+++v++v+   ++t+ ++ l+
  EFC39496.1 1841 TFSVVVYNTAPKSASKSLSVQRDTSNPTVTlNDLLVGATDAEGDSISVSSVSMisQNTGASVLLS 1905
                  6778888**************99886655559*******************96424444444444 PP

  == domain 18  score: -2.5 bits;  conditional E-value: 3.3
  Cadherin_4   16 avddsatvtedtpltitagnvlandtDvd.gddltvtavtvagtyGtltlnadG 68  
                   vd ++++t d+++++ + ++ +  +    +d  t + +++a  +G  ++ a+G
  EFC39496.1 1949 CVDYTISTTKDSSAVTFETDLKSKLSSYCvNDVCTLALASTASLNGVGSIAANG 2002
                  677788888876655545666665555432444555555555555555555554 PP

  == domain 19  score: 6.6 bits;  conditional E-value: 0.0047
  Cadherin_4    4 titvtgvndaPvavddsa....tvtedtpltitagnvlandtDvdgdd.ltvtavt.....vagtyGtltlnadGsf 70  
                   i ++  n+aP++ d ++    + + ++ +t++    l+   D+d  d +  ++++     ++ +  +l++ +d ++
  EFC39496.1 2037 KIIINQPNNAPTVYDYTYsysiSRASNDYVTFD-YVSLSSSDDPDASDsIVLSSISsvgtcTTSSISSLSITSDNQI 2112
                  689************987333356779999995.4445777789965557667666222222334456777777665 PP

  == domain 20  score: 33.6 bits;  conditional E-value: 1.8e-11
  Cadherin_4    2 tvtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvag......tyGt 61  
                  t+ it+++   +Pvav+d++++t +t + i+  ++l+nd+D  g+++++t+++  +      t Gt
  EFC39496.1 2142 TAKITINAISSPPVAVNDAVSTTYNTYIDIPVSTLLGNDYDSLGGTFSFTGINCPTgdstycTAGT 2207
                  899*************************************************85322332223355 PP

  == domain 21  score: -1.4 bits;  conditional E-value: 1.5
  Cadherin_4   24 tedtpltitagnvl...........andtDvd.gddltvtavtvagtyGtltlnadGsft 71  
                  te t+l +   nvl           + d+D+  g ++t++  t   +y +    + Gs+t
  EFC39496.1 2726 TEKTTLIN---NVLpydesatfflgTKDSDIAvGSTTTWQDGTSMSSYTNYQSKQPGSYT 2782
                  66666666...7777777777777799999885556888888766666666666666655 PP

>> Cadherin_5  Cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   0.0   9.6e-08   0.00025      30      89 ..      80     138 ..      73     145 .. 0.85
   2 !   24.0   0.3   1.1e-08   2.8e-05      26      95 ..     174     243 ..     146     246 .. 0.75
   3 !   15.1   0.8   6.7e-06     0.017       2      87 ..     247     328 ..     244     336 .. 0.70
   4 ?    2.1   1.0     0.073   1.9e+02      39      97 ..     386     447 ..     338     448 .. 0.63
   5 !    9.9   0.6   0.00028      0.72      28      85 ..     470     528 ..     452     539 .. 0.80
   6 ?    1.5   1.3      0.11   2.9e+02      25      96 ..     567     639 ..     548     641 .. 0.72
   7 !   24.8   2.7   6.3e-09   1.6e-05      21      85 ..     658     724 ..     641     737 .. 0.73
   8 !   10.7   2.1   0.00016       0.4      32      88 ..     743     798 ..     734     807 .. 0.85
   9 !    6.0   0.2    0.0046        12      28      85 ..     830     888 ..     807     898 .. 0.75
  10 !   14.8   0.2     8e-06      0.02      27      95 ..     924     993 ..     900     997 .. 0.70
  11 ?   -1.6   0.2       1.1   2.7e+03      75      97 ..    1011    1033 ..    1007    1034 .. 0.86
  12 ?   -3.2   1.4       3.4   8.6e+03      32      93 ..    1064    1125 ..    1043    1128 .. 0.69
  13 !   15.8   0.4   4.1e-06      0.01       2      88 ..    1131    1222 ..    1130    1231 .. 0.76
  14 ?    1.5   0.1      0.11   2.9e+02      40      82 ..    1269    1312 ..    1255    1314 .. 0.66
  15 !    9.9   1.7   0.00027       0.7      62      97 ..    1319    1354 ..    1311    1355 .. 0.87
  16 !   27.3   3.1     1e-09   2.7e-06      27      97 ..    1379    1448 ..    1355    1449 .. 0.79
  17 ?   -2.4   0.0       1.9   4.9e+03      51      80 ..    1598    1627 ..    1595    1628 .. 0.88
  18 ?    1.1   0.1      0.15   3.9e+02      69      91 ..    1710    1734 ..    1677    1740 .. 0.70
  19 !   15.3   1.3   5.7e-06     0.015       2      77 ..    1742    1810 ..    1741    1844 .. 0.76
  20 !   36.4   2.1   1.5e-12   3.9e-09       2      97 ..    1848    1942 ..    1847    1943 .. 0.85
  21 !    4.9   0.1    0.0099        25      12      87 ..    1953    2032 ..    1944    2040 .. 0.66
  22 !    5.3   0.2    0.0076        19      30      97 ..    2073    2147 ..    2043    2148 .. 0.69
  23 ?   -0.2   0.1      0.39   9.9e+02       5      64 ..    2154    2209 ..    2151    2256 .. 0.73

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 9.6e-08
  Cadherin_5  30 LanasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtt 89 
                 L n+ D+ g +L++ ++t+   +G+ v  + G + +t    y G+ t++Y+v+ g +++t
  EFC39496.1  80 LLNDIDPRGGNLTILNVTQ-PLHGKAVLSSAGMVIYTSIGSYAGNDTFEYSVTNGWTTAT 138
                 56888999*********85.55********************************963332 PP

  == domain 2  score: 24.0 bits;  conditional E-value: 1.1e-08
  Cadherin_5  26 aaqLLanasDvdgdtLsvssl.tadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasl 95 
                 ++++ a+++D+dgd+Ls++++  ++ + G++++       +tp+  +n    l+Yt+sDg +  ++  +++
  EFC39496.1 174 ESEMGAKIKDIDGDDLSITDIiLVSPNVGSLISFDQNYLYYTPAYGFNNIELLNYTISDGYA-NVSGVITI 243
                 55677899************96778889*****9999999********************84.44455555 PP

  == domain 3  score: 15.1 bits;  conditional E-value: 6.7e-06
  Cadherin_5   2 ndaPvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvssltadaenGtvv.dngdGtftftpeanyn.GevtlsYtvsDgegg 87 
                 nd+P+++ +  + +++++   t++   +L n+ D++gd++s++   + + +G v  +  + ++ + p+      +  ++Y+++Dg  +
  EFC39496.1 247 NDKPTAEPD--TYTITKNALGTFN---ILDNDFDINGDNISITTAGLGS-SGVVLiSSDNSNIEYIPKPFVApYTDAFEYEITDGALT 328
                 666666654..3456666666666...9****************98777.677762555567888887544423459********633 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.073
  Cadherin_5  39 dtLsvssl..tadaenGtvvdngdG..tftftpeanynGevtlsYtvsDgeggtttatasltv 97 
                  +Lsv+s   ++   +G++ + +    + ++tp++    + +++ +vsDg   ++ at++++v
  EFC39496.1 386 SSLSVTSSmaSVYYPTGDFLQVKKNlySLVYTPDQGVIYTDSFKVKVSDGV-DVAYATITINV 447
                 3477766522334456777765555336789*******************6.67777777766 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00028
  Cadherin_5  28 qLLanasDvdgdtLsvssl.tadaenGtvvdngdGtftftpeanynGevtlsYtvsDge 85 
                 ++++n+  + gd L+ +   ++++  G++v+  d ++ ++p++ + G+ + +Y v  ++
  EFC39496.1 470 DVISNDYSASGDVLKLNFAsSTSNFGGKLVKIDDNNVKYEPAKGFLGQDEAQYIVINTN 528
                 578888899999998887734456679**************************996654 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.11
  Cadherin_5  25 taaqLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGev.tlsYtvsDgegg.tttataslt 96 
                 +a +LL +  D++gd+++ +s+ a+++ G   +   G+  ++ +a  +  v  +++tv D  g+ +  ata+++
  EFC39496.1 567 SALNLLRDSYDPNGDSINYNSI-AKSTYGVSLSFTSGNANVNYAALSSVYVdYVDFTVVDIDGAiSQVATATIN 639
                 4456******************.567789888888888888877777766635788898888773445666666 PP

  == domain 7  score: 24.8 bits;  conditional E-value: 6.3e-09
  Cadherin_5  21 altitaaqLLanasDvdgdtLsvssltadaenGtvv.....dngdG.tftftpeanynGevtlsYtvsDge 85 
                  ++i    +L+ asD+dgd+L+v+s t+  ++G+v      d  dG +ft    +ny G+ ++++ vsD  
  EFC39496.1 658 RIIIP---VLTYASDIDGDSLHVESFTQ-GSKGSVSrvtltDGTDGlQFTTSGSNNYVGSDSFTFVVSDYG 724
                 44554...8999**************86.44676654444488899999999*****************73 PP

  == domain 8  score: 10.7 bits;  conditional E-value: 0.00016
  Cadherin_5  32 nasDvd.gdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggt 88 
                 n++D+d +d+++v++ t+ +  G+v +    t+tft ++   G  t++ t +Dg  ++
  EFC39496.1 743 NVTDIDsQDSVTVKDATVGS-CGSVSK-TSSTVTFTSNKGSVGVCTVTITFTDGLLNS 798
                 89****9999******9766.899887.889**********************96444 PP

  == domain 9  score: 6.0 bits;  conditional E-value: 0.0046
  Cadherin_5  28 qLLanasDvdgdtLsvssltadaenGtvvdngdGtftft.peanynGevtlsYtvsDge 85 
                 ++++  sD+d+d+Ls s  ++d++ G+   n+d   ++t p++   G++++  + +Dg 
  EFC39496.1 830 DIMSTLSDADNDALSYSVSSYDSTFGSPSINSDKALVWTlPQTPKLGTTQIVISFTDGW 888
                 588899********9999999*************9888845555668888888888884 PP

  == domain 10  score: 14.8 bits;  conditional E-value: 8e-06
  Cadherin_5  27 aqLLanasDvdgdtLsvsslta...daenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasl 95 
                  ++L++ sD dgd+Ls +s t    + ++G+       ++ ++  +   G+ +++Y+++Dg  +t+++++++
  EFC39496.1 924 IDILSECSDNDGDSLSFDSTTPivtAPAQGSASI-VSSKVYYKQSTASVGSYSITYKITDGI-QTSSNSITV 993
                 469**************99743333444666555.55788899999999************6.444444443 PP

  == domain 11  score: -1.6 bits;  conditional E-value: 1.1
  Cadherin_5   75 vtlsYtvsDgeggtttatasltv 97  
                   t++Y+  Dg   +++at++++v
  EFC39496.1 1011 KTFTYKAFDGALYSSAATVTVKV 1033
                  58********9999999999877 PP

  == domain 12  score: -3.2 bits;  conditional E-value: 3.4
  Cadherin_5   32 nasDvdgdtLsvssltadaenGtvvdngdG..tftftpeanynGevtlsYtvsDgeggtttata 93  
                    +D+dgd  s s  + +++  +++d ++G   + +t +  ++ + + +   sDg  +t++at+
  EFC39496.1 1064 TLTDADGDYYSLSFGSGSSAYCSLIDLSNGikGVKYTRN-AFDSTDSCKVVLSDGF-STSAATL 1125
                  468889888666655556667899988888433444433.4888888999999997.4444444 PP

  == domain 13  score: 15.8 bits;  conditional E-value: 4.1e-06
  Cadherin_5    2 ndaPvvssevtlaagseDtaltitaaqLLanasDvd.gdt..LsvssltadaenGtvvdn.gdGtftftpeanyn...GevtlsYtvsDgeggt 88  
                  n+ Pv+++  tl     + ++ i+  ++L+ a+D+d +d   Ls+ s+  ++  G+ ++n  +G++ + p++      G+ t+ Yt+sDg +++
  EFC39496.1 1131 NNVPVAAN-FTLDYSGGNIQYGIS-IDVLSSATDADiQDVpfLSILSVGNSKLYGSEAANiVNGQVFYFPDQSLVkalGTDTVAYTISDGLSTS 1222
                  55566654.466555555566666.789********878799******88888887765538*********9887777************7544 PP

  == domain 14  score: 1.5 bits;  conditional E-value: 0.11
  Cadherin_5   40 tLsvssltadaenGtvv.dngdG.tftftpeanynGevtlsYtvs 82  
                  t  v++    ++ G+vv +  d  t+t++p   y G+  ++ +vs
  EFC39496.1 1269 TTVVQGS-EPNQGGSVVvSSVDEkTVTYKPSGSYLGNEIFKLNVS 1312
                  3344444.4555677664444444************998888776 PP

  == domain 15  score: 9.9 bits;  conditional E-value: 0.00027
  Cadherin_5   62 tftftpeanynGevtlsYtvsDgeggtttatasltv 97  
                  +ftft  a    + t++Y vsDg+ +++++t+++++
  EFC39496.1 1319 SFTFTNVAGNVATQTFTYVVSDGKDTSASKTVTISI 1354
                  79999999999999**********999999999987 PP

  == domain 16  score: 27.3 bits;  conditional E-value: 1e-09
  Cadherin_5   27 aqLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynG.evtlsYtvsDgeggtttatasltv 97  
                   +LL+ ++D dgd+Ls++s t+++ nG v + +  ++ + p+    G +++++Y+v Dg  +t+++t+++++
  EFC39496.1 1379 INLLSVVTDSDGDSLSITSFTQTN-NGAVSSINSTSVKYIPTPLTAGfTTSFTYSVYDGY-TTISNTVTISI 1448
                  35******************9776.9****************999994569********7.77778888776 PP

  == domain 17  score: -2.4 bits;  conditional E-value: 1.9
  Cadherin_5   51 enGtvvdngdGtftftpeanynGevtlsYt 80  
                  ++Gt+   g G + f   +n n + + s+t
  EFC39496.1 1598 GSGTILLSGSGLYIFSISTNLNANFQWSFT 1627
                  579*******************99988875 PP

  == domain 18  score: 1.1 bits;  conditional E-value: 0.15
  Cadherin_5   69 anynGev..tlsYtvsDgeggttta 91  
                  +  nG++  +++Yt++D  +++  a
  EFC39496.1 1710 TFINGPAtdSFQYTITDQIATSNVA 1734
                  4456765448*******98766655 PP

  == domain 19  score: 15.3 bits;  conditional E-value: 5.7e-06
  Cadherin_5    2 ndaPvvssevtlaagseDtaltitaaqLLan.asDvdgdtLsvsslta.daenGtvvdngdGtftftpeanynGevtl 77  
                  n aPv++s    +ag+   + t+t+a+++++  sD+d+d+Ls  ++t+ + ++ tv+d   Gt+++tp +       +
  EFC39496.1 1742 NTAPVATS---FSAGKVTWKNTLTTASVVSKyCSDADKDSLSLFGVTQgKYGTTTVTDSTSGTIVYTPSSS------I 1810
                  88999985...56777777888999998876269************75245566788***********864......3 PP

  == domain 20  score: 36.4 bits;  conditional E-value: 1.5e-12
  Cadherin_5    2 ndaPvvssevtlaagseDt.altitaaqLLanasDvdgdtLsvssl.tadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttataslt 96  
                  n aP+ +s+ +l +++ Dt + t+t ++LL +a+D++gd++svss+  +++++G  v  +  t  +t  + y G++ +s+t +Dg+  ++t + ++t
  EFC39496.1 1848 NTAPKSASK-SL-SVQRDTsNPTVTLNDLLVGATDAEGDSISVSSVsMISQNTGASVLLSSNTAKLTYITSYLGSIVFSFTLTDGQ-LSSTYNYNVT 1941
                  888988865.55.7888886889***********************5568889999999**************************9.5555566555 PP

  Cadherin_5   97 v 97  
                  +
  EFC39496.1 1942 I 1942
                  5 PP

  == domain 21  score: 4.9 bits;  conditional E-value: 0.0099
  Cadherin_5   12 tlaagseDtaltitaaqLLanasDv...dgdtLsvssltadaenGtvvdngdG..tftftpeanynGevtlsYtvsDgegg 87  
                  t+++++  +a+t++ ++L ++ s     d  tL  +s +  ++ G++++ng+   t+t + ++  nGe   +Y+ s   g+
  EFC39496.1 1953 TISTTKDSSAVTFE-TDLKSKLSSYcvnDVCTLALASTASLNGVGSIAANGNNllTYTQNSKSSSNGESYSTYSYSNRAGQ 2032
                  55444444455555.66655555541114556888888888889*********4455555567788999888887776665 PP

  == domain 22  score: 5.3 bits;  conditional E-value: 0.0076
  Cadherin_5   30 LanasDvd.gdtLsvsslta.....daenGtvvdngdGtftftpeanynGevtlsYtvsDgegg.tttatasltv 97  
                  L+   D+d +d++  ss++      +++  ++   +d ++ f  +  + G+ ++s  vsD      +++ta++t+
  EFC39496.1 2073 LSSSDDPDaSDSIVLSSISSvgtctTSSISSLSITSDNQIKFLRNPSFIGSCSFSLVVSDSDLRnPISKTAKITI 2147
                  67788999888876666644344555667888899*************************964325566666665 PP

  == domain 23  score: -0.2 bits;  conditional E-value: 0.39
  Cadherin_5    5 PvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvssltadaenGtvvdngdGtft 64  
                  Pv+ ++  + +++ +t + i  ++LL n+ D  g t s ++++  +  G+ +    Gt t
  EFC39496.1 2154 PVAVND--AVSTTYNTYIDIPVSTLLGNDYDSLGGTFSFTGINCPT--GDSTYCTAGTPT 2209
                  666654..457888999999999********999999999998766..555554555544 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       4.7   1.2e+04     102     119 ..     876     895 ..     870     911 .. 0.69
   2 !   70.4   0.7   8.5e-23   2.2e-19       1     116 [.    2267    2381 ..    2267    2385 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 4.7
                 TSEEEEEEEESS--CSS..H CS
         VWA 102 nakkviilltdGksndg..d 119
                 ++++++i +tdG  +++   
  EFC39496.1 876 GTTQIVISFTDGWVSKTasY 895
                 7899********99764442 PP

  == domain 2  score: 70.4 bits;  conditional E-value: 8.5e-23
                  EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHT..BTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHH CS
         VWA    1 DivfvlDgSgsmgeenfekvkefikklvekle..vgpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyaleklfks 95  
                  DivfvlDgS+s++++n+ ++++f+++l   +   ++p+ t++g++qfs+++ t+ +l+d +sk+++l+a++++ +  ++t+    ++++a++ ++++
  EFC39496.1 2267 DIVFVLDGSSSIDAGNWINMQNFASNLTVGFGsnISPTATKIGIIQFSTTTVTHLDLKDGTSKTAVLNAISSAGQLKSSTN-SILGINNAVSMVLSQ 2362
                  9*******************************766*************************************877777777.889********9999 PP

                  HGTSSTTSEEEEEEEESS--C CS
         VWA   96 sagaRenakkviilltdGksn 116 
                   ++  + ++k++i +tdG sn
  EFC39496.1 2363 GRK--DITRKLLIHITDGMSN 2381
                  999..7789*********886 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.7     2e-12     5e-09       1     106 [.    2268    2378 ..    2268    2379 .. 0.89

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 2e-12
       VWA_2    1 lvfvlDtSgSmrngdygptrleaakdaveallksl.....p.gdrvglvtfsdgpevliplt..kdkakilnalrnleakgggtnlaaaLqlarkal 89  
                  +vfvlD+S S+ +g     ++  +++++++l   +     p  +++g+++fs++  ++++l+  ++k+++lna+ +  + +  tn   +++ a +++
  EFC39496.1 2268 IVFVLDGSSSIDAG-----NWINMQNFASNLTVGFgsnisPtATKIGIIQFSTTTVTHLDLKdgTSKTAVLNAISSAGQLKSSTNSILGINNAVSMV 2359
                  79************.....8**********99966666887577*****************87789****************************976 PP

       VWA_2   90 .kkrr.kgekrvivlitDg 106 
                   +++r   +++ +++itDg
  EFC39496.1 2360 lSQGRkDITRKLLIHITDG 2378
                  444445789999******9 PP

>> Cadherin_3  Cadherin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.3   3.2e+03      87     111 .]     109     133 ..      90     133 .. 0.92
   2 !   11.8   0.2   7.2e-05      0.18       8     111 .]     332     435 ..     327     435 .. 0.86
   3 ?    1.0   0.0      0.16     4e+02      83     111 .]     955     983 ..     943     983 .. 0.93
   4 ?   -1.5   0.0      0.98   2.5e+03       7      25 ..    1027    1045 ..    1024    1061 .. 0.83
   5 ?   -1.0   0.0      0.69   1.8e+03      74     111 .]    1392    1436 ..    1347    1436 .. 0.67
   6 ?   -3.2   0.1       3.3   8.5e+03      88     110 ..    1703    1726 ..    1699    1727 .. 0.83
   7 ?   -0.2   0.0      0.38   9.7e+02       5      54 ..    2141    2188 ..    2137    2198 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.3
  Cadherin_3  87 aglvvyvhdgseslsdsfsfqvtDG 111
                 ag v+y+  gs + +d f+++vt+G
  EFC39496.1 109 AGMVIYTSIGSYAGNDTFEYSVTNG 133
                 7899******99**********998 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 7.2e-05
  Cadherin_3   8 eitikpvndeaPvlttntglrvlegsskvittenLsaeDeDtppeeltytvvrgpsnG..rlelkga...pgekvtsFtqadidaglvvyvhdgsesls 101
                 ++ +k vn  +P+++ +  ++v ++s++ +   +L+ +D+D   + +t+t v+++ +G   l+++++      ++  F q + +  ++vy+ d+   ++
  EFC39496.1 332 YVFVKIVNS-PPTVSDKV-FNVAKNSKNNLL--DLTFSDPDVL-DTVTLTAVSKLARGnsSLSVTSSmasVYYPTGDFLQVKKNLYSLVYTPDQGVIYT 425
                 677888998.99999777.*********998..9*********.9**********88866899888854444455589999889999999999989*** PP

  Cadherin_3 102 dsfsfqvtDG 111
                 dsf+++v+DG
  EFC39496.1 426 DSFKVKVSDG 435
                 *********9 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.16
  Cadherin_3  83 adidaglvvyvhdgseslsdsfsfqvtDG 111
                 a i +++v+y+++  +  s s+++++tDG
  EFC39496.1 955 ASIVSSKVYYKQSTASVGSYSITYKITDG 983
                 678899********9*************9 PP

  == domain 4  score: -1.5 bits;  conditional E-value: 0.98
  Cadherin_3    7 leitikpvndeaPvlttnt 25  
                   ++t+k vn ++P+++ ++
  EFC39496.1 1027 ATVTVKVVNANKPQISDQS 1045
                  5799999*******99876 PP

  == domain 5  score: -1.0 bits;  conditional E-value: 0.69
  Cadherin_3   74 gekvtsFtqa......didaglvvyvhdg.seslsdsfsfqvtDG 111 
                  + ++tsFtq+       i++ +v y+ +  + +++ sf+++v DG
  EFC39496.1 1392 SLSITSFTQTnngavsSINSTSVKYIPTPlTAGFTTSFTYSVYDG 1436
                  445556665422212257777777777765667777777777776 PP

  == domain 6  score: -3.2 bits;  conditional E-value: 3.3
  Cadherin_3   88 glvvyvhdg.seslsdsfsfqvtD 110 
                    v+y+++  + + +dsf++++tD
  EFC39496.1 1703 LTVYYKNTFiNGPATDSFQYTITD 1726
                  57899998766799*********9 PP

  == domain 7  score: -0.2 bits;  conditional E-value: 0.38
  Cadherin_3    5 ftleitikpvndeaPvlttntglrvlegsskvittenLsaeDeDtppeel 54  
                  +t +iti+ +   +Pv + n  ++ + ++   i  ++L  +D+D+     
  EFC39496.1 2141 KTAKITINAISS-PPVAV-NDAVSTTYNTYIDIPVSTLLGNDYDSLGGTF 2188
                  6889******99.55555.66699999*****************976555 PP

>> Spo0M  SpoOM protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00012      0.31      70     132 ..    1332    1396 ..    1299    1403 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00012
                  EEEEEEEE--EEE-TT-EEEEEEEEE--TT-----TT--EEEEEEEEESS..S--EEEEEEEEE- CS
       Spo0M   70 elarvrvaeaftiepgeereipfelelpletPitlggakvwleTeldiag..avDpgDkDpleve 132 
                  +  ++ v+++    + ++ +i ++ + p  tPit+++   +++ +ldi+    v  +D D l++ 
  EFC39496.1 1332 QTFTYVVSDGKDTSASKTVTISITNNAPSATPITISKHWATVQGGLDINLlsVVTDSDGDSLSIT 1396
                  4556789999999999********************************96214566777777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2816 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       606  (0.0338); expected 358.6 (0.02)
Passed bias filter:                      254  (0.014167); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.30u 0.33s 00:00:01.63 Elapsed: 00:00:00.57
# Mc/sec: 14889.78
//
Query:       EFC39497.1  [L=212]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (212 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       792  (0.0441742); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.25s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1372.44
//
Query:       EFC39498.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-19   70.6   0.6    2.6e-19   69.8   0.6    1.4  1  TLD       TLD
     0.0089   16.0   0.0      0.018   15.1   0.0    1.6  1  Kelch_4   Galactose oxidase, central domain


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.8   0.6   2.9e-23   2.6e-19       1     138 [.     133     283 .]     133     283 .] 0.83

  Alignments for each domain:
  == domain 1  score: 69.8 bits;  conditional E-value: 2.9e-23
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkss.nkkfygdsesflfsl.....spkfkvyks.....tgkn.kaylntssdgl 87 
                 lly++s+dg++ ++++ k++n+g t+++ik + + ifG+++s  w+ +  ++f  +++ flfsl     + +fk +++     ++++   ++++s+ g+
  EFC39498.1 133 LLYKASRDGFQSKQFHTKCDNQGATVTIIKADTGAIFGGYTSAAWNTTvMSQFAYSERAFLFSLvsnsgEERFKKLNQlappnSPSQgRSIYSHSRFGP 231
                 79*******************************************5441458**************99977888888776655333355666666679* PP

         TLD  88 gfGggqpkfsLwidsslekgtsrhs.....etfengllsgaseerfkikdiEVWgl 138
                 +fGgg   ++L+i s+ +++t + +       f+ + l+g s ++  +kdiEV++l
  EFC39498.1 232 TFGGG---HDLYICSNAHENTGSYChpntyADFGKEYLAG-SYKEWLVKDIEVYSL 283
                 ***95...79999999888766666664666677999996.99**********975 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0     2e-06     0.018       3      40 ..     154     200 ..     153     218 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2e-06
     Kelch_4   3 aghsatsipdgtiylfGGrgedg.........tllndlylldlstnt 40 
                 +g+++t i  +t ++fGG+++ +         + +  ++l++l +n+
  EFC39498.1 154 QGATVTIIKADTGAIFGGYTSAAwnttvmsqfAYSERAFLFSLVSNS 200
                 689******************88999999999999999999999994 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       670  (0.0373696); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1778.62
//
Query:       EFC39499.1  [L=483]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.2e-09   36.5   0.0    3.2e-08   34.0   0.0    2.3  2  PseudoU_synth_1  tRNA pseudouridine synthase
     0.0063   16.1   5.6     0.0092   15.6   5.6    1.2  1  SR-25            Nuclear RNA-splicing-associated protein
  ------ inclusion threshold ------
      0.046   13.5   0.2      0.094   12.5   0.2    1.5  1  Repressor_Mnt    Regulatory protein Mnt
       0.95   10.3   8.1        2.4    9.0   0.0    2.6  2  Colicin-DNase    DNase/tRNase domain of colicin-like bacterio
        1.5    7.5   6.3          2    7.1   6.3    1.2  1  Presenilin       Presenilin


Domain annotation for each model (and alignments):
>> PseudoU_synth_1  tRNA pseudouridine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.52   1.9e+03      41      62 ..     162     183 ..      45     216 .. 0.65
   2 !   34.0   0.0     9e-12   3.2e-08       4     108 .]     297     413 ..     294     413 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.52
  PseudoU_synth_1  41 kellvvtvkgsgFldhqVRamv 62 
                      k+  +++++ + ++d++V a+ 
       EFC39499.1 162 KNCKDIRLQRACRTDRGVSAVR 183
                      2222666666666666666554 PP

  == domain 2  score: 34.0 bits;  conditional E-value: 9e-12
  PseudoU_synth_1   4 elvGthdfgsfckqkqek.kntvrtileaaieevsge.ekellvvtvkgsgFldhqVRamvgvlfav........gqgklspedvkellnakk. 86 
                      +++G h f +f+ + +++  ++ r+++  +i e + e + +++v++++g++F+ hq+R m+g+++a         +   ++  +v++  +    
       EFC39499.1 297 HFEGIHLFHNFTVDAKPGsDSSRRHVKTLKIIEQNLEgDLPHVVIEISGRSFMLHQIRMMIGTVIALmrgmapnmNTTVQDNTIVNDFFENLFk 390
                      89*********77777776677777777777644333035677*********************999787777773344444444444443332 PP

  PseudoU_synth_1  87 .rkkiavetapavglvlfhvrYd 108
                       ++++  ++ap +gl+l + +++
       EFC39499.1 391 aQTEVLLPMAPSEGLFLDNLDFP 413
                      34457899999999998887776 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   5.6   2.6e-06    0.0092      61     123 ..      12      74 ..       1      95 [. 0.53

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.6e-06
       SR-25  61 rrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkkkkkkkekkkakekakae 123
                  +++s+++     s+ ++ sss+ +++++ k+ k+k + +++++kk+kk+++k+++++k++ +
  EFC39499.1  12 PTTTSTTDGTTVGSTTTTISSSELVNEQNDKKRKNKFNNNNNNNKKNKKQNNKQQNSNKERDD 74 
                 334555555566666666666666666666666666666555555333333333333333333 PP

>> Repressor_Mnt  Regulatory protein Mnt
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.2   2.6e-05     0.094       8      19 ..     433     444 ..     432     445 .. 0.93

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 2.6e-05
                    HHHHHHHHHHHH CS
  Repressor_Mnt   8 ADeqaElvKKtV 19 
                    ADe+aE++KK V
     EFC39499.1 433 ADEHAEIFKKDV 444
                    9*********87 PP

>> Colicin-DNase  DNase/tRNase domain of colicin-like bacteriocin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   5.0      0.14     5e+02      27      61 ..      36      70 ..      14      81 .. 0.57
   2 ?    9.0   0.0   0.00067       2.4      25      75 ..     199     249 ..     174     256 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.14
  Colicin-DNase 27 srevqfksankklkeelakdpklankftkeqleqi 61
                   ++e + k+ ++k+ ++ ++++k++++ +k+q +++
     EFC39499.1 36 VNEQNDKKRKNKFNNNNNNNKKNKKQNNKQQNSNK 70
                   44455555555555555555555555333333333 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00067
  Colicin-DNase  25 kksrevqfksankklkeelakdpklankftkeqleqikkgkkpngytWHHh 75 
                    k++ +++ ++  k l +++++  + +n    +q++ ++ +++p+ ++ HH 
     EFC39499.1 199 KDTFKFNNEELCKTLNDRINNHVRIKNLNLMDQIKIFNIQRVPSRFVLHHW 249
                    2344555556667777778877666666557899999*************5 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   6.3   0.00056         2     239     312 ..       6      78 ..       1     115 [. 0.49

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00056
  Presenilin 239 eeaekkkeeasesskeeeseeesseksaqsse...seeeseeesseaessaeesseekeseessesseeeeeeeeee 312
                 +e+++  +++s+++ ++  +++++ +s    +   +e+++++++++ ++++++++++k++++++++s++e+++e+++
  EFC39499.1   6 QETTTIPTTTSTTDGTTVGSTTTTISS----SelvNEQNDKKRKNKFNNNNNNNKKNKKQNNKQQNSNKERDDEDAD 78 
                 222222222222222222222222211....1233344444444444444444444444444444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (483 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2645  (0.147526); expected 358.6 (0.02)
Passed bias filter:                      882  (0.049194); expected 358.6 (0.02)
Passed Vit filter:                       171  (0.00953762); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.86u 0.31s 00:00:01.17 Elapsed: 00:00:00.51
# Mc/sec: 2867.62
//
Query:       EFC39500.1  [L=502]
Description: membrane protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.5e-07   29.5   0.1    2.6e-05   24.1   0.1    3.1  2  Thioredoxin  Thioredoxin


Domain annotation for each model (and alignments):
>> Thioredoxin  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.1   1.5e-09   2.6e-05       3      61 ..      14      78 ..      12      91 .. 0.83
   2 ?    1.6   0.0     0.015   2.7e+02      73      93 ..     146     166 ..     114     175 .. 0.80

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.5e-09
                 EESSHHHHHHHHTT....TSSEEEEEEE-TTSHHHHCHHHHHHHHHHHCTT..TSEEEEEETTTS CS
  Thioredoxin  3 lvltkenFeeevak....ekklvlveFyApwCghCkalaPeleklaeelkd..kvklakvdvden 61
                 +  + ++Fe+++      +++ ++++  A+wCg+C ++ +++ek+  ++ d  ++ +  +d ++ 
   EFC39500.1 14 VYENVTEFEKALLTnqntPNHVLVLDVHATWCGKCNSVLSTFEKINMDYGDdhQIIFGVLDSQKL 78
                 5667788999987755556778899************************9988999998887765 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.015
                  SSEEEEEETTEEEEEEESS-H CS
  Thioredoxin  73 iPtlklfkngkevkkyegare 93 
                   P +++fk+g+ ++k+ g ++
   EFC39500.1 146 EPHFLIFKEGELIRKIRGVNT 166
                  599********9999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (502 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3662  (0.20425); expected 358.6 (0.02)
Passed bias filter:                      560  (0.0312343); expected 358.6 (0.02)
Passed Vit filter:                       176  (0.0098165); expected 17.9 (0.001)
Passed Fwd filter:                        77  (0.00429472); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.44u 0.40s 00:00:01.84 Elapsed: 00:00:00.58
# Mc/sec: 2590.09
//
Query:       EFC39501.1  [L=358]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-13   49.6  15.2    3.7e-13   49.6  15.2    3.7  3  DUF2040   Coiled-coil domain-containing protein 55 (DUF2040)


Domain annotation for each model (and alignments):
>> DUF2040  Coiled-coil domain-containing protein 55 (DUF2040)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   3.3     0.042   7.5e+02      14      77 ..      52     113 ..      41     119 .. 0.70
   2 !   49.6  15.2   2.1e-17   3.7e-13      30     121 .]     146     238 ..     136     238 .. 0.85
   3 ?   -6.1  11.4         1   1.8e+04      51      86 ..     288     323 ..     259     357 .. 0.54

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.042
     DUF2040  14 svydYDevYDslkeakekkkakkkeekkerkpkYienLlkaaekRkrereraeerklqkereae 77 
                 s+++ De  +++ + k++++++kk +++++++ +  +L +++++ k+ +  +      ++ e e
  EFC39501.1  52 SLFEEDE--EQIVDTKSNNNNQKKGQQHSSHAHFYAKLQQEKNNDKKPSMNIDVSSWGRDEEDE 113
                 5555555..4566667777777777888889999999999998888877776666666666655 PP

  == domain 2  score: 49.6 bits;  conditional E-value: 2.1e-17
     DUF2040  30 ekkkakkk.eekkerkpkYienLlkaaekRkrereraeerklqkereaegdefadkekFVTsaYkkkleelkkleeeekrreeeeekkdvtkk 121
                 ++++ + + e+kk + +kYi +L+k ae Rk+e+e+a+ r++qk+ ea+    ++ + FVT+ Yk+ l+e++++ e+++++ + e ++dvtkk
  EFC39501.1 146 NQNEVTVEgESKKPEGSKYIAHLVKVAEDRKKEKELAQMRRVQKQAEANSATTSETQVFVTEEYKQYLKEQERWTEQKEKQLQDEINNDVTKK 238
                 3333332303334566**************************************************************************986 PP

  == domain 3  score: -6.1 bits;  conditional E-value: 1
     DUF2040  51 LlkaaekRkrereraeerklqkereaegdefadkek 86 
                  l++  +R+ e+e+  e+k +++ e       +ke 
  EFC39501.1 288 ALEETINRNDEQELSSEKKRKRQDEDISTTATNKED 323
                 234444566666666666655555555555555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (358 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3347  (0.186681); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.82u 0.36s 00:00:01.18 Elapsed: 00:00:00.58
# Mc/sec: 1852.83
//
Query:       EFC39502.1  [L=466]
Description: Hypothetical protein NAEGRDRAFT_72760 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.1e-06   26.0   0.0    1.4e-05   24.8   0.0    1.6  1  F-box-like  F-box-like
    7.6e-06   25.7   0.0    3.1e-05   23.7   0.0    2.1  1  F-box       F-box domain
  ------ inclusion threshold ------
      0.069   13.5   0.3      0.069   13.5   0.3    3.8  4  PRANC       PRANC domain
       0.34   11.3   3.6        2.4    8.6   0.2    3.2  3  FRB_dom     FKBP12-rapamycin binding domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   0.0   3.2e-09   1.4e-05       2      38 ..      95     131 ..      94     133 .. 0.93

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 3.2e-09
  F-box-like   2 srLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldt 38 
                 + LP+EiL++I+ yL+  +++ l + ++r++++++++
  EFC39502.1  95 NELPNEILVHILIYLNGAQIIKLECLSKRFYQLIHHE 131
                 68*******************************9765 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.7   0.0     7e-09   3.1e-05       2      38 ..      93     129 ..      92     133 .. 0.94

  Alignments for each domain:
  == domain 1  score: 23.7 bits;  conditional E-value: 7e-09
                 HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHT CS
       F-box   2 tlsrLPsevlrhILerLplsdllalrrVSkgwrilid 38 
                 ++ +LP+e+l hIL +L+   ++ l + Sk++++li 
  EFC39502.1  93 SFNELPNEILVHILIYLNGAQIIKLECLSKRFYQLIH 129
                 6899******************************996 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.3   1.5e-05     0.069      46      95 ..      66     117 ..      40     119 .. 0.79
   2 ?   -2.3   0.1       1.3   5.6e+03      35      64 ..     136     165 ..     123     175 .. 0.64
   3 ?    1.5   0.1     0.086   3.8e+02      51      74 ..     224     247 ..     203     250 .. 0.86
   4 ?   -0.2   0.5      0.28   1.2e+03      16      49 ..     378     413 ..     368     436 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.5e-05
       PRANC  46 ksakkrykliekaievlnnicsk..kslWnlLPiEIkykIleyLndkdLknl 95 
                 +s++  ++l+e+  e l n  ++   ++ n LP+EI  +Il yLn  ++ +l
  EFC39502.1  66 DSMTGSSSLLEEHHELLLNSSRNiiANSFNELPNEILVHILIYLNGAQIIKL 117
                 5555555666666666666666666789*****************9998776 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.3
       PRANC  35 kiYgklikkiiksakkrykliekaievlnn 64 
                  +Y+k+i++    +k+++k  ++++  l n
  EFC39502.1 136 RNYNKKIRRGRIPSKEKRKHQRRLSINLAN 165
                 678888888766666666655555554444 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.086
       PRANC  51 rykliekaievlnnicskkslWnl 74 
                  + ++ekai++l++ ++++s+ n 
  EFC39502.1 224 EKYNLEKAIRSLEDEITSHSYFNE 247
                 56789***********99999886 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.28
       PRANC  16 inllvrlinkkklkklk.sl.kiYgklikkiiksak 49 
                 +++  r+++k    k++ sl +iY k  kk  + +k
  EFC39502.1 378 TSMSNRTLSKVDNEKVQsSLnTIYAKWFKKWGEIIK 413
                 468888888888888885446888888887544444 PP

>> FRB_dom  FKBP12-rapamycin binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1       0.1   4.5e+02      33      63 ..       1      31 [.       1      33 [. 0.87
   2 ?   -0.8   0.0      0.46   2.1e+03      11      32 ..      76      96 ..      62     149 .. 0.51
   3 ?    8.6   0.2   0.00055       2.4       8      47 ..     336     375 ..     333     407 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.1
     FRB_dom 33 mlklleplhellekgpetlreasFaqafgre 63
                ml + e+lhe+ e + ++++e++ ++af+++
  EFC39502.1  1 MLPQQESLHEQEEVNSNSIMEDAIVEAFEND 31
                55667899***99999************975 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.46
     FRB_dom 11 ElwhegLeeAsrlyfgeknvea 32
                E  he L ++sr + + +++++
  EFC39502.1 76 EEHHELLLNSSRNIIA-NSFNE 96
                4444444444444433.23333 PP

  == domain 3  score: 8.6 bits;  conditional E-value: 0.00055
     FRB_dom   8 lwhElwhegLeeAsrlyfgeknveamlklleplhellekg 47 
                 + + +  + LeeA ++ f++++  +m+k+++++h +   +
  EFC39502.1 336 TQESQAQQLLEEAYAHDFKDRQDVGMIKFIHEMHFNNPIT 375
                 566788899************************9665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (466 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       778  (0.0433934); expected 358.6 (0.02)
Passed bias filter:                      354  (0.0197445); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2689.15
//
Query:       EFC39503.1  [L=619]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.6e-21   74.8   0.7      3e-20   73.2   0.7    1.8  1  VWA              von Willebrand factor type A domain
    9.8e-11   42.3   0.0    2.3e-10   41.1   0.0    1.7  1  Methyltransf_12  Methyltransferase domain
    6.8e-10   39.5   0.7    6.8e-10   39.5   0.7    1.9  1  VWA_2            von Willebrand factor type A domain
    7.9e-10   38.8   0.0    1.3e-09   38.1   0.0    1.4  1  Methyltransf_23  Methyltransferase domain
    1.1e-09   38.9   0.0    4.8e-09   36.8   0.0    2.2  1  Methyltransf_25  Methyltransferase domain
      5e-08   33.5   0.0      2e-07   31.6   0.0    2.1  2  Methyltransf_11  Methyltransferase domain
    1.2e-05   25.2   0.0    2.6e-05   24.1   0.0    1.6  1  Methyltransf_31  Methyltransferase domain
    0.00016   21.3   0.0    0.00037   20.1   0.0    1.6  1  Methyltransf_PK  AdoMet dependent proline di-methyltransferas
  ------ inclusion threshold ------
      0.014   14.9   0.2       0.12   12.0   0.0    2.4  3  MTS              Methyltransferase small domain
      0.083   12.0   0.2       0.25   10.4   0.0    1.8  2  DREV             DREV methyltransferase
      0.086   12.3   0.2         15    5.2   0.1    2.5  2  ATP_synth_reg    ATP synthase regulation


Domain annotation for each model (and alignments):
>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.2   0.7   1.8e-23     3e-20       1     116 [.       2     116 ..       2     120 .. 0.94

  Alignments for each domain:
  == domain 1  score: 73.2 bits;  conditional E-value: 1.8e-23
                 EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHT..BTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHG CS
         VWA   1 DivfvlDgSgsmgeenfekvkefikklvekle..vgpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssa 97 
                 DivfvlDgS+s++++n+ ++++f+++l   +   ++p+ t++g++qfs+++ t+ +l+d +sk+++l+a++++ +  ++t+    ++++a++ ++++ +
  EFC39503.1   2 DIVFVLDGSSSIDAGNWINMQNFASNLTVGFGsnISPTATKIGIIQFSTTTVTHLDLKDGTSKTAVLNAISSAGQLKSSTN-SILGINNAVSMVLSQGR 99 
                 9*******************************766*************************************877777777.889********999999 PP

                 TSSTTSEEEEEEEESS--C CS
         VWA  98 gaRenakkviilltdGksn 116
                 +  + ++k++i +tdG sn
  EFC39503.1 100 K--DITRKLLIHITDGMSN 116
                 9..7789*********886 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.1   0.0   1.4e-13   2.3e-10       1      99 []     504     616 ..     504     616 .. 0.82

  Alignments for each domain:
  == domain 1  score: 41.1 bits;  conditional E-value: 1.4e-13
  Methyltransf_12   1 LeiGcGtGsllrallekl..pdieytgvDispsaiedakeklakrennnnnnv.elealdlldldgg...........ssfDlvvasnvlhhlk 80 
                      +++G+GtG+l+ ++l++   +  ++ +vD+s+ ++ + + k+ k  n+n   + e  +++ +dl+             +++ ++ +  v+hhl+
       EFC39503.1 504 MDFGAGTGTLTLMFLNHYlsQIERIDAVDVSSGMLSQLQDKITKLTNDNMLTCgEKIVINNIDLELAeqslhpislnkGKYNVIMSGMVFHHLE 597
                      69***************995555566*********9999999999988765542222233333333345899********************** PP

  Methyltransf_12  81 direvldnirklLkpgGrl 99 
                      +i e ++ i + L+pgG++
       EFC39503.1 598 NIPEKIKLISSYLAPGGMF 616
                      *****************86 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.5   0.7   4.2e-13   6.8e-10       1     106 [.       3     113 ..       3     114 .. 0.89

  Alignments for each domain:
  == domain 1  score: 39.5 bits;  conditional E-value: 4.2e-13
       VWA_2   1 lvfvlDtSgSmrngdygptrleaakdaveallksl.....p.gdrvglvtfsdgpevliplt..kdkakilnalrnleakgggtnlaaaLqlarkal.k 90 
                 +vfvlD+S S+ +g     ++  +++++++l   +     p  +++g+++fs++  ++++l+  ++k+++lna+ +  + +  tn   +++ a +++ +
  EFC39503.1   3 IVFVLDGSSSIDAG-----NWINMQNFASNLTVGFgsnisPtATKIGIIQFSTTTVTHLDLKdgTSKTAVLNAISSAGQLKSSTNSILGINNAVSMVlS 96 
                 79************.....8**********99966666887577*****************87789****************************97644 PP

       VWA_2  91 krr.kgekrvivlitDg 106
                 ++r   +++ +++itDg
  EFC39503.1  97 QGRkDITRKLLIHITDG 113
                 4445789999******9 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.1   0.0   8.1e-13   1.3e-09      20     117 ..     497     618 ..     473     619 .] 0.69

  Alignments for each domain:
  == domain 1  score: 38.1 bits;  conditional E-value: 8.1e-13
  Methyltransf_23  20 lraggrvLdiGcGtGillevl.rengfsvtgvDlspeaveiae....................kakkaqkdqfdeqeaae.......pqgkfdl 85 
                       +++  v+d+G+GtG+l+  +   +  +++ +D+ ++ +++++                      +++++    e    +       ++gk+++
       EFC39503.1 497 SNSNLLVMDFGAGTGTLTLMFlNHYLSQIERIDAVDVSSGMLSqlqdkitkltndnmltcgekIVINNIDLELAE----QslhpislNKGKYNV 586
                      3566689********988777444444555555555555555544476666666666666665222222222223....13444777999**** PP

  Methyltransf_23  86 IvlrevlehvpdppellrqiatllkpgGylll 117
                      I + +v++h+++ pe ++ i ++l+pgG ++l
       EFC39503.1 587 IMSGMVFHHLENIPEKIKLISSYLAPGGMFIL 618
                      ****************************9876 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.0     3e-12   4.8e-09       1      97 []     503     614 ..     503     614 .. 0.83

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 3e-12
                      EEEET-TTSHHHHHHHCTS..TSSEEEEEESSHHHHHHHHHHHHH..........TTT......TEEEEESBCCGBSSSTTTEEEEEEESTGGG CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrl..gkakvtgvDiseemleaareraee..........egl......nvefvqgdaedlpfedgsfDlvvssgalhh 76 
                      v+d+G+GtG+ltl++++++  + +++ +vD+s++ml + + ++ +          e        ++e+ +++++ +++++g++++++s +++hh
       EFC39503.1 503 VMDFGAGTGTLTLMFLNHYlsQIERIDAVDVSSGMLSQLQDKITKltndnmltcgE-KivinniDLELAEQSLHPISLNKGKYNVIMSGMVFHH 595
                      89****************99669*****************8888877655544441.04555447777888888899***********555*** PP

                      SSHHHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  77 lsdedlekalkeiarvLkpgG 97 
                      l+  ++++ +k i++ L pgG
       EFC39503.1 596 LE--NIPEKIKLISSYLAPGG 614
                      97..89999***********9 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       5.9   9.7e+03      18      34 ..      49      66 ..      28      76 .. 0.56
   2 !   31.6   0.0   1.2e-10     2e-07       2      96 .]     505     618 ..     504     618 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 5.9
                     T.SEEEEEES-HHHHHHH CS
  Methyltransf_11 18 g.arvvgvDlskemlkla 34
                       ++v+ +Dl + + k+a
       EFC39503.1 49 StTTVTHLDLKDGTSKTA 66
                     245666666666665555 PP

  == domain 2  score: 31.6 bits;  conditional E-value: 1.2e-10
                      EET-TTSHHHHHHHHTT....SEEEEEES-HHHHHHHHHHCCHHT-...............EEEETTEECCCTSS-TT-EEEEEEES-CCC-CC CS
  Methyltransf_11   2 dvGcGtGrlaealakrg....arvvgvDlskemlklakekaseegl...............kvefvvadaeklpfednsfDlvvssevlhhved 76 
                      d+G+GtG l+  + +++    +r+ +vD+s  ml + ++k+ +  +                +e+ +++++ + ++++++ +++s +v+hh+e+
       EFC39503.1 505 DFGAGTGTLTLMFLNHYlsqiERIDAVDVSSGMLSQLQDKITKLTNdnmltcgekivinniDLELAEQSLHPISLNKGKYNVIMSGMVFHHLEN 598
                      99************8888899****************9999999999978888877777666666999999999******************** PP

                      HHHHHHHHHHHEEEEEEEEE CS
  Methyltransf_11  77 pekalkeiaRvLkpgGllvi 96 
                        + +k i   L pgG++++
       EFC39503.1 599 IPEKIKLISSYLAPGGMFIL 618
                      *****************985 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0   1.6e-08   2.6e-05       2     109 ..     498     618 ..     497     619 .] 0.84

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 1.6e-08
  Methyltransf_31   2 dkglrvlDlGCGtGeltfelaeelgpkae.vvGiDiseeaielArenaqklgldnveFeq.....gdiee.lekl.led.....ekfDlilsne 82 
                      +++l v+D G+GtG+lt+ +     +++e +  +D s  ++++ + +  kl  dn+  +       +i   l ++ l++      k+++i+s  
       EFC39503.1 498 NSNLLVMDFGAGTGTLTLMFLNHYLSQIErIDAVDVSSGMLSQLQDKITKLTNDNMLTCGekiviNNIDLeLAEQsLHPislnkGKYNVIMSGM 591
                      68999*************99987777777799**********************998777333324444334444444499999********** PP

  Methyltransf_31  83 vlnaladpdkileeiervlkpggilli 109
                      v+++l + ++ ++ i+++l pgg +++
       EFC39503.1 592 VFHHLENIPEKIKLISSYLAPGGMFIL 618
                      ************************997 PP

>> Methyltransf_PK  AdoMet dependent proline di-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.0   2.3e-07   0.00037      52     159 ..     496     618 ..     480     619 .] 0.79

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 2.3e-07
  Methyltransf_PK  52 gkrevkvaldcGaGiGrvtknlLlkll...skvDlvepvekflekakeelae.........ekkkvgkvyvvglqeftPe.....egrYdliWi 128
                        ++++ ++d GaG G +t  +L ++l   +++D v++ + +l+++++++++         ++k v + + + l e + +     +g+Y++i  
       EFC39503.1 496 LSNSNLLVMDFGAGTGTLTLMFLNHYLsqiERIDAVDVSSGMLSQLQDKITKltndnmltcGEKIVINNIDLELAEQSLHpislnKGKYNVIMS 589
                      45778899***************99995556789999999*********9999999888886666666666666443322335659******** PP

  Methyltransf_PK 129 qWcvghLtDedlvaflkrckkalkpnGlivv 159
                        +  hL  e++ + +k   ++l+p+G++++
       EFC39503.1 590 GMVFHHL--ENIPEKIKLISSYLAPGGMFIL 618
                      ******9..5788888999999999999876 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       4.7   7.7e+03      10      44 ..      94     123 ..      91     128 .. 0.66
   2 ?   -0.7   0.0      0.55     9e+02      38      91 ..     210     261 ..     208     269 .. 0.74
   3 ?   12.0   0.0   7.1e-05      0.12      34      77 ..     502     547 ..     489     580 .. 0.67

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 4.7
                 STTTTS--HHHHHHHHHCHCCTCSEEEEET-TTSH CS
         MTS  10 vFskdklDkGsklLletlpkelsgkvlDlGcGaGv 44 
                 v s+++ D+  klL++  +      +  l cG+G+
  EFC39503.1  94 VLSQGRKDITRKLLIHITDG-----MSNLPCGMGA 123
                 56777777777777755444.....3458888886 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.55
                 ET-TTSHHHHHHHHHTTC.EEEEEESBHHHHHHHHHHHHHTTGC.EEEEE-STTT CS
         MTS  38 lGcGaGvlgaalakespeaevtlvdvdarAlesakenleankle.vevvasdvle 91 
                 l +G+G l ++  +  p+   +l+ vd+  l s  +++ +n ++ v+ ++++vl 
  EFC39503.1 210 LSSGYGQLQIQKMNYDPN---NLIVVDWSDLSSVYQTVIDNSCNlVDSTQTNVLV 261
                 678999999999998888...3445567778888888888888877777777765 PP

  == domain 3  score: 12.0 bits;  conditional E-value: 7.1e-05
                 EEEEET-TTSHHHHHHHHHT.TC.E.EEEEESBHHHHHHHHHHHHH CS
         MTS  34 kvlDlGcGaGvlgaalakes.peae.vtlvdvdarAlesakenlea 77 
                  v+D+G+G+G l++++++++ +++e +++vdv+   l   +  +++
  EFC39503.1 502 LVMDFGAGTGTLTLMFLNHYlSQIErIDAVDVSSGMLSQLQDKITK 547
                 499***********998876245557999*9998888777665544 PP

>> DREV  DREV methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.98   1.6e+03       8      41 ..     251     285 ..     245     296 .. 0.79
   2 ?   10.4   0.0   0.00015      0.25      94     136 ..     499     545 ..     472     574 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.98
        DREV   8 lseslq.alfvaslpdaetqsflenskklsanlfi 41 
                 l +s q +++v++   +   ++l ++  +s++l +
  EFC39503.1 251 LVDSTQtNVLVPLSSSGYSIQYLGKTLSKSSYLNY 285
                 6777774689999999999*******999999854 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00015
        DREV  94 edkklldlGaGdGeitkrvaptfee....vyatelsetmrdrlkkkk 136
                  +  ++d+GaG G +t +  +++      + a ++s+ m  +l+ k 
  EFC39503.1 499 SNLLVMDFGAGTGTLTLMFLNHYLSqierIDAVDVSSGMLSQLQDKI 545
                 455689**********9988874322444**************9875 PP

>> ATP_synth_reg  ATP synthase regulation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0     0.015        25      18      37 ..     177     196 ..     174     198 .. 0.94
   2 ?    5.2   0.1    0.0093        15       1      23 [.     379     402 ..     379     403 .. 0.95

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.015
  ATP_synth_reg  18 fNsyTlrGRaNvvlAtYagi 37 
                    +Ns T+ G  N  + tY++i
     EFC39503.1 177 LNSWTVGGASNPEKSTYGSI 196
                    8*****************98 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0093
  ATP_synth_reg   1 MAGgeeadq.kltGlskyfNsyTl 23 
                    M Gg++ +q   +G s ++Ns+T+
     EFC39503.1 379 MSGGSQYTQgTVKGPSGVINSTTV 402
                    99999******************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (619 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       632  (0.0352502); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.49
# Mc/sec: 3766.69
//
Query:       EFC39504.1  [L=571]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00043   20.0   3.6      0.002   17.9   0.2    3.6  4  LRR_8     Leucine rich repeat
      0.001   19.4  14.7     0.0039   17.6   0.7    6.1  5  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0       0.4   3.6e+03      47      57 ..     166     176 ..     164     177 .. 0.72
   2 !   17.9   0.2   2.2e-07     0.002      24      61 .]     246     283 ..     241     283 .. 0.93
   3 ?   -2.4   0.0      0.48   4.3e+03      20      24 ..     310     314 ..     298     329 .. 0.48
   4 ?   -0.1   0.0     0.091   8.2e+02      24      34 ..     442     452 ..     426     465 .. 0.65

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.4
                 T--S-.EEE-- CS
       LRR_8  47 gLpsLrsLdLs 57 
                 gL++L++Ld+s
  EFC39504.1 166 GLENLKFLDVS 176
                 67778877765 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 2.2e-07
                 -TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  24 lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 l+n + Ld snNl+t +s + + +L+++++L +s N +
  EFC39504.1 246 LPNIEKLDVSNNLITEFSIRKLFSLEKIKELKVSTNEI 283
                 89********************************9976 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 0.48
                 SSTT- CS
       LRR_8  20 aFkgl 24 
                 +Fk l
  EFC39504.1 310 FFKAL 314
                 33333 PP

  == domain 4  score: -0.1 bits;  conditional E-value: 0.091
                 -TT--EEE--S CS
       LRR_8  24 lsnLkvLdLsn 34 
                 ++nL++L+L +
  EFC39504.1 442 FPNLNYLSLCY 452
                 46666666665 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0      0.01        94      17      32 ..     159     177 ..     149     186 .. 0.68
   2 !   17.6   0.7   4.3e-07    0.0039       1      33 [.     247     281 ..     247     294 .. 0.86
   3 ?    0.9   0.3     0.078     7e+02      21      30 ..     319     329 ..     287     359 .. 0.65
   4 ?    1.8   0.2     0.041   3.6e+02      19      35 ..     439     452 ..     417     464 .. 0.76
   5 ?   -1.3   0.1      0.37   3.3e+03       3      25 ..     487     509 ..     485     532 .. 0.59

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.01
                 S-...HHH-TT--EEE-.- CS
       LRR_4  17 pl...leklpnLkeLdLsg 32 
                 p    + +l nLk Ld+s 
  EFC39504.1 159 PYwdfCPGLENLKFLDVST 177
                 44443336********964 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 4.3e-07
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgN 33 
                 pn e+Ld snN +t+++    + +l + keL +s N
  EFC39504.1 247 PNIEKLDVSNNLITEFSIrklF-SLEKIKELKVSTN 281
                 799************9997744.6*********888 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.078
                 H.-TT--EEE- CS
       LRR_4  21 k.lpnLkeLdL 30 
                 + lp+L++L +
  EFC39504.1 319 SlLPKLTSLRV 329
                 44666666654 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.041
                 HHH-TT--EEE-.-S-- CS
       LRR_4  19 leklpnLkeLdLsgNnl 35 
                  e +pnL +L+L  + +
  EFC39504.1 439 SECFPNLNYLSL--C-Y 452
                 4469*******9..3.3 PP

  == domain 5  score: -1.3 bits;  conditional E-value: 0.37
                 --EEE--SS---E-S-HHH.-TT- CS
       LRR_4   3 LevLdLsnNqltdipllek.lpnL 25 
                 L++L+L  +++t ++  +k l+ L
  EFC39504.1 487 LIKLNLL-CKVTIFGASYKaLTTL 509
                 6667766.4666544433222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (571 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       427  (0.0238162); expected 358.6 (0.02)
Passed bias filter:                      343  (0.019131); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.29s 00:00:00.89 Elapsed: 00:00:00.47
# Mc/sec: 3669.96
//
Query:       EFC39505.1  [L=375]
Description: Enoyl-CoA hydratase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.3e-37  127.5   0.0    8.5e-37  126.8   0.0    1.3  1  ECH_1     Enoyl-CoA hydratase/isomerase
    4.5e-25   88.8   0.1    8.1e-25   88.0   0.1    1.4  1  ECH_2     Enoyl-CoA hydratase/isomerase
  ------ inclusion threshold ------
      0.057   13.6   1.8        0.1   12.7   1.8    1.4  1  SPT16     FACT complex subunit (SPT16/CDC68)
       0.31   11.0   2.8       0.67    9.9   2.3    1.7  1  YliH      Biofilm formation protein (YliH/bssR)


Domain annotation for each model (and alignments):
>> ECH_1  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  126.8   0.0   1.9e-40   8.5e-37       3     246 ..      88     353 ..      86     358 .. 0.82

  Alignments for each domain:
  == domain 1  score: 126.8 bits;  conditional E-value: 1.9e-40
                 ETTEEEEEE--CGCTTEE-HHHHHHHHHHHH..HHHHSTTECEEEEEEBTS...........EEEEEB-HHHHHHHHC....HHHHHHHCCHHH.HHHH CS
       ECH_1   3 eagvaviklnrPeavNalsaelltEliqale..kleddksvravvLtGgdk...........aFaaGadlkemaeeek....akqallkeevle.lwtk 83 
                 ++++ vi++nrPe++N+l++e+   + + +e  ++ +++ + a++LtG +            aF+aG+d   ++e+      ++++ +++ +++ l  +
  EFC39505.1  88 HKTIGVITINRPEKMNSLCPETAVQFKALMEssRITNNNRLAAIILTGAPPapdsegkmnhpAFSAGGDYDFLLERIDdtpfNNANRMSQFYDSfLSPL 186
                 6799*********************99999833466999*********763233334444448******776665533333533333333333314457 PP

                 HHHSSSEEEEEE-SEEETHHHHHHHHSSEEEEETTTEEE-GGGGGTS--CTTCHHHHHHHHHHHHHHHHHHHT-EEEHHHHHHCTSSSEEESG.GGHHH CS
       ECH_1  84 lytvpkpviaavnGaaigGGlelalacDiviaadnasfglnelklGlipgaggtqilarkvGkskAeeilllgkkisaqealkvGlvdkvvpe.eqlle 181
                 l+ +p+p+ia ++G+a+g+Gl +a a+Di+++  +a+ + n++k+Gl pg+g +  l+  vG++ A ++ll+g+ i+aq a++ G+v  v+       +
  EFC39505.1 187 LRICPVPTIACMSGHAVGAGLGIACATDIRVMEATAKMSFNFVKIGLSPGMGSSLLLPYLVGHQVASYMLLTGDLITAQKAKEYGVVLDVMEGaTACRH 285
                 889****************************************************************************************98466778 PP

                 HHHHHHHHHHHSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCTSHHHH...HHHHHHHTCSH- CS
       ECH_1 182 ealelaeklaekspaalrqlkealnakledalaeqleaeaklfestfskddik...eGlqaflEkrkp 246
                    e+a ++a++s  a r   +al+ +     ++ ++ e++ + + f+ +++k   + ++   E+rk+
  EFC39505.1 286 RSFEIAVQIAKSSHIASRLCLHALRVQKIAGITACMYRESDAQVQSFADEEMKsliMEMKDKEERRKA 353
                 899********************999988888888999999999999998988666666665666665 PP

>> ECH_2  Enoyl-CoA hydratase/isomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.0   0.1   1.8e-28   8.1e-25       1     250 [.      91     357 ..      91     372 .. 0.76

  Alignments for each domain:
  == domain 1  score: 88.0 bits;  conditional E-value: 1.8e-28
                 .EEEEE--GGGTT-B-HHHHHHHHHHHHH..HCC-TT-SEEEEEESSSS..........ECE--B--HHHHHHHHCS-THHHHHHHHHHH..HHHHHHC CS
       ECH_2   1 vgvitLnrpkalNaLslemvralkealke..wekddevklvvlkgagek..........afCAGgDvralyeaakegkkeeeeffreeYk..lnyliat 85 
                 +gvit+nrp+++N+L  e + ++k+ +++  + ++++ ++++l+ga +           af+AGgD   l e ++++  ++++ +++ Y+  l  l+  
  EFC39505.1  91 IGVITINRPEKMNSLCPETAVQFKALMESsrITNNNRLAAIILTGAPPApdsegkmnhpAFSAGGDYDFLLERIDDTPFNNANRMSQFYDsfLSPLLRI 189
                 689**********************998622689999********95545555567777*****************9555444455555433899**** PP

                 -SS-EEEEE-BEEETHHHHHHTTSSEEEE-TT-EEE--GGGGT----TTHHHHHHCSST.THHHHHHHH---B-HHHHHHTTS--EE--GGGH...HHH CS
       ECH_2  86 ypkpvvalmdGivmGgGvGlsvhgsfrvvtertvfAmPEtaIGlfPDvGgsyfLsrlpg.elGlylalTGarlkgadalaaglathyvpsekl...eal 180
                 +p p++a m G ++G G+G+++ + +rv+  +++++   ++IGl P  G s +L+ l g +++ y+ lTG+ ++++ a + g+   +++ +      ++
  EFC39505.1 190 CPVPTIACMSGHAVGAGLGIACATDIRVMEATAKMSFNFVKIGLSPGMGSSLLLPYLVGhQVASYMLLTGDLITAQKAKEYGVVLDVMEGATAcrhRSF 288
                 ********************************************************96659**********************9999987765222444 PP

                 HHHHHTT........--------......----SHHHHHHHHHHHT.-S-TTTHHHHHH..T..--SHHHH CS
       ECH_2 181 eeaLaelessdeeaveevleelaeeaeeeeeeselaekreaidrlfsadsveeiveaLek.aeaeedewak 250
                 e a++ ++ss + a + +l++l+ ++ +  + + + ++ +a  + f+++++++++ ++++ +e+++++  +
  EFC39505.1 289 EIAVQIAKSS-HIASRLCLHALRVQKIAGIT-ACMYRESDAQVQSFADEEMKSLIMEMKDkEERRKAKKQQ 357
                 4444443332.44445555555544444433.445455666666777889999999998632222222333 PP

>> SPT16  FACT complex subunit (SPT16/CDC68)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   1.8   2.3e-05       0.1      67     118 ..     317     368 ..     287     373 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2.3e-05
       SPT16  67 ikeltfrskdekklqevfreikelkkkvkkreaekkekedlveqekLilsks 118
                 i   ++r++d++  + + +e+k+l  ++k +e+++k k++  ++ekL l k+
  EFC39505.1 317 ITACMYRESDAQVQSFADEEMKSLIMEMKDKEERRKAKKQQEKEEKLRLAKE 368
                 67789******98888999****************************99886 PP

>> YliH  Biofilm formation protein (YliH/bssR)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   2.3   0.00015      0.67      46      82 ..     337     373 ..     325     375 .] 0.89

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00015
        YliH  46 lfelnrelrdkalrlqlaldqeerdalrraeealaaa 82 
                 +  l  e++dk  r + + +qe+ + lr+a+ea aaa
  EFC39505.1 337 MKSLIMEMKDKEERRKAKKQQEKEEKLRLAKEAAAAA 373
                 556899***************************9998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1606  (0.0895755); expected 358.6 (0.02)
Passed bias filter:                      669  (0.0373138); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 2064.99
//
Query:       EFC39506.1  [L=368]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (368 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       737  (0.0411066); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 2264.57
//
Query:       EFC39507.1  [L=244]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.6e-13   50.5   0.0    3.4e-13   50.1   0.0    1.1  1  Thioredoxin_4  Thioredoxin
    7.6e-06   25.8   0.0     0.0031   17.3   0.0    2.5  1  DSBA           DSBA-like thioredoxin domain


Domain annotation for each model (and alignments):
>> Thioredoxin_4  Thioredoxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.1   0.0   3.8e-17   3.4e-13       3     152 ..      47     223 ..      45     238 .. 0.82

  Alignments for each domain:
  == domain 1  score: 50.1 bits;  conditional E-value: 3.8e-17
                    SSSEEES-..TT-SEEEEEEE-TT-HHHHHHHHHHH.HHHHHHHHTT......SEEEEEEE-..---..S.TTTHHHHHHHTT--TTHHHHHHHHH CS
  Thioredoxin_4   3 etdiviGn..pdApvtvieyedlrCphCakfeeeve.klleeyidtG......kvkfiirdfpldke..k.eslkaamaarcageespeaflaika 86 
                    +++++iGn  p+  v  + + dl+Cp Ca+ ++++  +l++ y ++G      kv f  + +pl+++  + +s +  ++ + + + + +  +++ +
     EFC39507.1  47 KNSWTIGNssPNTLVEFEMFLDLTCPDCATHFQSITkPLVQYYFNNGtsgnqdKVVFSLHLMPLPMHiaGfYSAQTYSIVSKFSKADRNVCWKFLD 142
                    578999983345666667788*********99998869********9999************9997632588999999999999999999999999 PP

                    HHHTHHHHTTS-.HHHHH...................HHHHHTS-------HHHHHHHHHHHHHHT--SS-EEEETTEEE- CS
  Thioredoxin_4  87 llysqqeewaes.lkelaae..............aldkdekfeacleeekldalveaeskeakkagiestPtfiingekve 152
                    l++s+q+ ++++ lk++ ++               l  +e+  + +++++  a+++ +   a+ +g+ +tP f++ng +v 
     EFC39507.1 143 LFFSNQSPASNAnLKNMNQAqifnliyatyvqplGLISYEQYLSEMNSQSSFAQAASMFGYATSRGLYGTPFFFVNGVNVF 223
                    99999988877755555544567778888888878888***************************************9963 PP

>> DSBA  DSBA-like thioredoxin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.5e-07    0.0031     118     182 ..     162     226 ..      62     231 .. 0.67

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.5e-07
                 S-TSSHHHHHHHHHHTTS..HHHHHHHHTSHHHHHHHHHHHHHHHHTT-SSSSEEEETTCEEEESS CS
        DSBA 118 qaitddqellevaekaGl.daeeldealeseavkeavrentaaaqslgvtGvPtvvvdgkrmvfGa 182
                 ++i+     +  ++ +Gl + e++   ++s+    + +     a s+g++G+P+++v+g +++ G 
  EFC39507.1 162 AQIFNLI-YATYVQPLGLiSYEQYLSEMNSQSSFAQAASMFGYATSRGLYGTPFFFVNGVNVFNGY 226
                 4455554.566677788889999************************************9777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (244 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       780  (0.0435049); expected 358.6 (0.02)
Passed bias filter:                      480  (0.0267723); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 1676.08
//
Query:       EFC39508.1  [L=1239]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-52  178.4   0.7    2.7e-52  177.8   0.7    1.3  1  Pkinase         Protein kinase domain
    7.6e-30  104.0   0.2    1.2e-29  103.5   0.2    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    2.7e-28   96.6   0.6    0.00079   19.3   0.0    9.3  8  NHL             NHL repeat
      3e-06   27.0   1.3       0.19   11.3   0.0    5.9  7  SGL             SMP-30/Gluconolactonase/LRE-like region
    7.3e-05   21.7   0.0    0.00014   20.7   0.0    1.4  1  Pkinase_fungal  Fungal protein kinase
    9.6e-05   22.3   1.3      0.065   13.2   0.0    4.6  3  SBBP            Beta-propeller repeat
     0.0014   18.5   0.4     0.0035   17.2   0.4    1.6  1  TMEM154         TMEM154 protein family
     0.0029   16.9   1.1     0.0062   15.8   1.1    1.5  1  7TM_GPCR_Srw    Serpentine type 7TM GPCR chemoreceptor Srw
     0.0055   16.3   3.5      0.011   15.2   3.5    1.5  1  DUF5385         Family of unknown function (DUF5385)
     0.0079   16.1   0.8     0.0079   16.1   0.8    1.8  2  RIFIN           Rifin
  ------ inclusion threshold ------
      0.012   15.2   1.8      0.027   14.1   0.7    2.0  2  RIO1            RIO1 family
      0.017   14.7   0.4      0.037   13.6   0.4    1.5  1  Stevor          Subtelomeric Variable Open Reading frame
      0.018   15.0   0.2      0.039   13.9   0.2    1.5  1  FixQ            Cbb3-type cytochrome oxidase component FixQ
      0.033   14.4   0.1      0.083   13.1   0.1    1.7  1  DPM3            Dolichol-phosphate mannosyltransferase subuni
      0.034   14.2   0.4      0.074   13.1   0.4    1.5  1  PspB            Phage shock protein B
      0.045   13.8   0.1       0.11   12.6   0.1    1.6  1  CD20            CD20-like family
      0.062   12.8   0.3       0.15   11.6   0.3    1.6  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL
      0.073   13.4   0.4       0.28   11.6   0.4    1.9  1  Ly49            Ly49-like protein, N-terminal region
      0.081   13.2   0.3        0.2   12.0   0.3    1.6  1  Orf78           Orf78 (ac78)
       0.18   11.7   2.9       0.61   10.0   0.7    2.4  2  TMCCDC2         Transmembrane and coiled-coil domain-containi
       0.26   11.4   4.8       0.98    9.5   4.8    2.1  1  EGF_Tenascin    Tenascin EGF domain
       0.32   10.7   2.6        0.7    9.6   2.6    1.5  1  ASFV_J13L       African swine fever virus J13L protein
       0.37   11.2  12.6       0.97    9.9  12.6    1.8  1  EGF_2           EGF-like domain
       0.95    8.8   6.7        1.3    8.4   0.2    3.8  4  MRJP            Major royal jelly protein
        6.8    6.2   8.4         18    4.8   8.4    1.7  1  SKG6            Transmembrane alpha-helix domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  177.8   0.7   3.7e-55   2.7e-52       2     264 .]     983    1238 ..     982    1238 .. 0.90

  Alignments for each domain:
  == domain 1  score: 177.8 bits;  conditional E-value: 3.7e-55
                  EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEE.EEEE--TTEBHHHHHHHHSS--H CS
     Pkinase    2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely.lvleyveggeladllerkgslse 97  
                  +++ k+G+G+fG+V++a++ +t+   A+K ik ++ ++ ++  +++E   l ++ hpni+++ ++f +k+el+ + +ey ++g+l++ll+  +++se
  EFC39508.1  983 KDMVKIGSGGFGSVFRAFDVKTNSFKALKAIKFQSYSELNQ--FMKEGLQLLNMAHPNIIKVNDMFVDKNELLvIEMEYYDKGDLTSLLK--VQISE 1075
                  6788******************************9999776..*************************99988477*************6..78*** PP

                  HHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHH CS
     Pkinase   98 eeakkiakqilegleylH.skgiiHrDlKpeNiLidekge....lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilye 189 
                  + +k+++ q+l++ley+H +k++iHrD+K +Ni+i+e  +    + ++DFGla+  + s   +s++gt+ +l+PE+  + +y+ ++Dv+slGv++y+
  EFC39508.1 1076 TLLKSVLFQMLNALEYIHeEKKLIHRDVKESNIFIKELTQdyiqVVLADFGLARDNSLSA-NNSYCGTPMFLSPELGLGASYGFNTDVYSLGVTIYQ 1171
                  ******************6667**************6444578899*********99988.9*********************************** PP

                  HHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase  190 lltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264 
                  l+t  +  +   ++ +++k+  q   + +il   +e++++++  s e+++l+ +++ kd  +R+ a++ll+ py+
  EFC39508.1 1172 LMTHDTTTA--ISHLHFSKDSSQ---VKQIL---TENMQKPNIYSTELIELVIEMVGKDSATRPQARQLLKYPYF 1238
                  *****9999..222334444444...55665...679999999*******************************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.5   0.2   1.6e-32   1.2e-29       6     256 ..     987    1233 ..     982    1235 .. 0.83

  Alignments for each domain:
  == domain 1  score: 103.5 bits;  conditional E-value: 1.6e-32
                   EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEE.EE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr    6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeeplliv.teyvkgGdLlkfLrkkekekl 100 
                   k+G+G fG+V+++       k++   a+K +k ++ +e  +++++e   + ++ hpni+k+  + +++++ll++ +ey ++GdL + L+ +    +
   EFC39508.1  987 KIGSGGFGSVFRAFDV----KTNSFKALKAIKFQSYSE-LNQFMKEGLQLLNMAHPNIIKVNDMFVDKNELLVIeMEYYDKGDLTSLLKVQ----I 1073
                   89***********988....455555778886555555.99*************************7777655559************998....8 PP

                   BHHHHHHHHHHHHHHHHHHHH.TTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHH CS
  Pkinase_Tyr  101 tlkdllsfalqvAkGmeyLes.kklvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsf 191 
                   + + l s+ +q+ +++ey+++ kkl+Hrd+   N++++e      +v ++DfGLard     + +++++      +++pE     ++  ++Dv+s 
   EFC39508.1 1074 SETLLKSVLFQMLNALEYIHEeKKLIHRDVKESNIFIKEltqdYIQVVLADFGLARDN----SLSANNSYCGTPMFLSPELGLGASYGFNTDVYSL 1165
                   888888999**********86267**************97754558899*******98....55555566666679******************** PP

                   HHHHHHHHTTSSGT.TTTSHHHHHHHHHHT..TEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr  192 GvllwEiftlgesp.ypglkneevleklke..gkrlekpekcpeelyelmkkcweedpeeRptfselv 256 
                   Gv+++ ++t+  ++ +++l+ ++  +++k+   ++++kp+  ++el el+ +   +d + Rp+ ++l+
   EFC39508.1 1166 GVTIYQLMTHDTTTaISHLHFSKDSSQVKQilTENMQKPNIYSTELIELVIEMVGKDSATRPQARQLL 1233
                   ********9766542444455554555544225679***************************99986 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.9   0.0   5.9e-05     0.042       1      22 [.     107     129 ..     107     134 .. 0.87
   2 !   14.2   0.0   4.8e-05     0.035       1      27 [.     163     188 ..     163     189 .. 0.95
   3 ?    5.5   0.0     0.027        19       1      27 [.     212     238 ..     212     239 .. 0.92
   4 ?    2.4   0.0      0.26   1.8e+02       4      27 ..     276     299 ..     273     300 .. 0.89
   5 !   15.6   0.0   1.7e-05     0.012       1      26 [.     334     360 ..     334     362 .. 0.93
   6 !   11.9   0.1   0.00026      0.19       1      27 [.     391     416 ..     391     417 .. 0.93
   7 !   19.3   0.0   1.1e-06   0.00079       1      28 []     511     538 ..     511     538 .. 0.96
   8 ?    1.1   0.0      0.68   4.9e+02       2      16 ..     792     807 ..     791     811 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 5.9e-05
                 BSSEEEEEEE.TTTEEEEEECCC CS
         NHL   1 fnyPhGvavd.snGdiyVaDsen 22 
                 +nyPh+v v+ ++G+iy+aD+ n
  EFC39508.1 107 LNYPHSVHVSnTTGEIYIADTFN 129
                 79******************644 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 4.8e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +nyP+ ++v sn+++y aDs n+r+++
  EFC39508.1 163 LNYPQAIRV-SNNEVYFADSANNRIRK 188
                 79*******.8**************97 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.027
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +++P+++ v+s+G++y  + +n+ ++v
  EFC39508.1 212 LYNPTSIEVSSDGNVYFLEKNNQKIRV 238
                 689*************99999999988 PP

  == domain 4  score: 2.4 bits;  conditional E-value: 0.26
                 EEEEEEETTTEEEEEECCCTEEEE CS
         NHL   4 PhGvavdsnGdiyVaDsenhrvqv 27 
                 ++G+avd  G+iy ++s+ +rv +
  EFC39508.1 276 CRGIAVDLEGNIYMSESYANRVLK 299
                 68***********99999999975 PP

  == domain 5  score: 15.6 bits;  conditional E-value: 1.7e-05
                 BSSEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvq 26 
                 +n+P+++++d s   +y++Ds+nhrv 
  EFC39508.1 334 LNFPQSLVMDsSYQSLYISDSNNHRVI 360
                 79***********************96 PP

  == domain 6  score: 11.9 bits;  conditional E-value: 0.00026
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+G+ + +nG +y++D++n r+++
  EFC39508.1 391 LNNPNGLFY-NNGILYISDTGNRRIRI 416
                 799******.6***********99986 PP

  == domain 7  score: 19.3 bits;  conditional E-value: 1.1e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 ++yP+  +vd+nG ++++Ds+n+ ++++
  EFC39508.1 511 LRYPTAFTVDQNGTLIICDSGNQLIRKY 538
                 78***********************987 PP

  == domain 8  score: 1.1 bits;  conditional E-value: 0.68
                 SSEEEEEEE.TTTEEE CS
         NHL   2 nyPhGvavd.snGdiy 16 
                 ++P++++v+ s+G+i+
  EFC39508.1 792 SNPNSIVVSeSTGEIF 807
                 58***********996 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       1.2   8.5e+02      10      37 ..      62     102 ..      53     164 .. 0.55
   2 !   11.3   0.0   0.00027      0.19     144     211 ..     172     240 ..     159     245 .. 0.85
   3 ?    0.9   0.0      0.39   2.8e+02     188     215 ..     278     305 ..     260     315 .. 0.75
   4 ?    3.7   0.0     0.053        38       2      37 ..     337     380 ..     336     434 .. 0.65
   5 ?    1.1   0.0      0.34   2.4e+02     184     214 ..     512     542 ..     481     556 .. 0.75
   6 ?   -2.3   0.0       3.7   2.6e+03     115     151 ..     773     809 ..     736     824 .. 0.64
   7 ?   -0.9   0.0       1.4   9.9e+02      86     159 ..    1040    1109 ..    1018    1117 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.2
         SGL  10 eegaLlwvDilgqrihrldpatgketv.............l 37 
                 ++g+L++v+  +  i +l+ +t++ t+             +
  EFC39508.1  62 NGGELYFVEEENHIIRKLSFVTNNITTiagngtagysdgvA 102
                 56778888888888888888888777733333333333331 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00027
         SGL 144 dgktlYlaDsltrkiwaydvdaeggkls.nrrvfadlkkgegepDGlavDaeGnvwvAvwgggkvvrfd 211
                  ++ +Y+aDs++++i ++  d + +++  n    +d++ +  +p ++ v ++Gnv+    +++k+++++
  EFC39508.1 172 SNNEVYFADSANNRIRKITTDGSITTIAgNGMQHFDTEFFLYNPTSIEVSSDGNVYFLEKNNQKIRVIE 240
                 5789*****************9977775155666999999999*************9999999998876 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.39
         SGL 188 GlavDaeGnvwvAvwgggkvvrfdpdGk 215
                 G+avD eGn+++    +++v ++d   k
  EFC39508.1 278 GIAVDLEGNIYMSESYANRVLKLDISTK 305
                 8889999999988888888877776555 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.053
         SGL   2 gEGpvwdeeegaLlwvDilgqrihrldpatgketv........l 37 
                 +++ v d   ++L+ +D  + r++r++ ++++           +
  EFC39508.1 337 PQSLVMDSSYQSLYISDSNNHRVIRYNISSDTVYRvagngtagY 380
                 67788888888888888888888888777766655333333330 PP

  == domain 5  score: 1.1 bits;  conditional E-value: 0.34
         SGL 184 gepDGlavDaeGnvwvAvwgggkvvrfdpdG 214
                  +p  ++vD++G ++++  g++ +++++   
  EFC39508.1 512 RYPTAFTVDQNGTLIICDSGNQLIRKYNDTT 542
                 5577788888888888888888888887664 PP

  == domain 6  score: -2.3 bits;  conditional E-value: 3.7
         SGL 115 galyrldpdgklervlddltipNGlawspdgktlYla 151
                 g l +l+++gk+  ++   + pN + +s+ +  +++a
  EFC39508.1 773 GRLKKLNKEGKVDIIMVFYSNPNSIVVSESTGEIFFA 809
                 5555555555555555555555555555555555554 PP

  == domain 7  score: -0.9 bits;  conditional E-value: 1.4
         SGL   86 lrfNDgvvdpdGrlwfGtmgdeeakgeevgalyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiw 159 
                  +++ND+ vd++  l +  m++  +++   ++l++++ + ++ +    +++ N+l   +++k+l++ D  +  i+
  EFC39508.1 1040 IKVNDMFVDKNE-LLVIEMEYYDKGDL--TSLLKVQIS-ETLLKSVLFQMLNALEYIHEEKKLIHRDVKESNIF 1109
                  578999999886.77778888888888..899999999.33333444677899999999999999999888876 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0     2e-07   0.00014     308     386 ..    1077    1151 ..    1066    1165 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 2e-07
  Pkinase_fungal  308 ll.ealrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievl 386 
                      ll ++l + +++++  +++++++HrD+ e Ni i + +++   + +L+D+ la + s  s+   ++   GT+ F++ e+ 
      EFC39508.1 1077 LLkSVLFQMLNALEYIHEEKKLIHRDVKESNIFIKELTQD-YIQVVLADFGLARDNSL-SA---NNSYCGTPMFLSPELG 1151
                      55147889999************************76555.8999*********9997.33...34589*****997765 PP

>> SBBP  Beta-propeller repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.1      0.24   1.7e+02      13      27 ..     213     227 ..     212     228 .. 0.93
   2 !   13.2   0.0     9e-05     0.065      15      28 ..     276     289 ..     272     290 .. 0.90
   3 ?    1.5   0.1      0.43   3.1e+02       4      24 ..     498     523 ..     498     523 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.24
        SBBP  13 tygngIavDsnGNiY 27 
                 +++++I v s+GN+Y
  EFC39508.1 213 YNPTSIEVSSDGNVY 227
                 689************ PP

  == domain 2  score: 13.2 bits;  conditional E-value: 9e-05
        SBBP  15 gngIavDsnGNiYv 28 
                 ++gIavD +GNiY+
  EFC39508.1 276 CRGIAVDLEGNIYM 289
                 89***********6 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.43
        SBBP   4 tqlG....gpgast.ygngIavDsnG 24 
                 tq+G    + ++++ y++  +vD+nG
  EFC39508.1 498 TQIGtvpgFDDNKLrYPTAFTVDQNG 523
                 788888886666677**********9 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.2   0.4   4.9e-06    0.0035      42     103 ..     873     935 ..     853     972 .. 0.54

  Alignments for each domain:
  == domain 1  score: 17.2 bits;  conditional E-value: 4.9e-06
     TMEM154  42 eslssaelsnesdqlelvlmiiiPlv..ll..illllvviiliqkkkrkrsKddekseaesdelds 103
                 +   s+e s++++ + +++  ++P     l  +++++++iili  + rk++K +  ++ +++ ++s
  EFC39508.1 873 QLRISPESSKQQETQVVLIATLVPILsvFLliVIIVILIIILI-FYFRKKKKSN--ENLNLEMIES 935
                 4444566666666666677788996411330033334444455.4445555555..4444443333 PP

>> 7TM_GPCR_Srw  Serpentine type 7TM GPCR chemoreceptor Srw
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   1.1   8.7e-06    0.0062     155     233 ..     854     932 ..     842     943 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 8.7e-06
  7TM_GPCR_Srw 155 wkpdknCaefpekysetrYvlvvselftandglllkiflliegiiskiipsillpiltilLiieLrkakkkrkklsssk 233
                   +  +++C+ + +++  +   l +s  ++++++  + +  +++ i+s ++  ++++il i+Li+  rk kk++++l+ + 
    EFC39508.1 854 CVSPNQCNCTLNYSGNECSQLRISPESSKQQETQVVLIATLVPILSVFLLIVIIVILIIILIFYFRKKKKSNENLNLEM 932
                   4556777633333344444556666666666666666677799999*****************************9333 PP

>> DUF5385  Family of unknown function (DUF5385)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   3.5   1.6e-05     0.011       5      35 ..     900     930 ..     898     940 .. 0.67

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.6e-05
     DUF5385   5 fliiliiiiiiilvivfllrkkkkqkeeeka 35 
                 ++++++ii+i i++ +f++rkkkk++e+ + 
  EFC39508.1 900 VFLLIVIIVILIIILIFYFRKKKKSNENLNL 930
                 4566666666667777887999998887554 PP

>> RIFIN  Rifin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.8   1.1e-05    0.0079     271     313 ..     886     928 ..     859     933 .. 0.67
   2 ?   -2.1   0.1       3.9   2.8e+03     148     206 ..    1016    1085 ..     986    1123 .. 0.56

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.1e-05
       RIFIN 271 attaslqtai.iasivaivvIvLimvIIYLiLRYrRKkKmkkKl 313
                 +++  + t + i s+  ++vI++ ++II Li  +r+KkK ++ l
  EFC39508.1 886 TQVVLIATLVpILSVFLLIVIIV-ILIIILIFYFRKKKKSNENL 928
                 33333334331455555555555.55666**********99876 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 3.9
       RIFIN  148 e......ageaagikaviellkkllklselkekkleslitatnyknvtslvkaikeeyeescll.....k 206 
                  +      +  ++g++    +  +++k++++  +k e l+ + +y ++  l++ +k +++e+ l+     +
  EFC39508.1 1016 QsyselnQFMKEGLQLLNMAHPNIIKVNDMFVDKNELLVIEMEYYDKGDLTSLLKVQISETLLKsvlfqM 1085
                  2322322233677777766677777788886666666677888889999999998888777665444321 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.7   3.7e-05     0.027      62     141 ..    1032    1112 ..     995    1128 .. 0.74
   2 ?   -1.5   0.0       2.2   1.6e+03      48     100 ..    1179    1231 ..    1169    1234 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 3.7e-05
                  HHHHHHTT--S--EEEEETTEEEEE--EETTEEGGBHHHCG.-HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEET CS
        RIO1   62 LkrleeagvpvPkpielkrhvlvmefigedgvaapklkdve.eeeeaeelyeevleemrklykeaglvHaDLSeyNvlvde 141 
                  L+ ++   ++v +    k++ lv e+   d+  ++ l +v+ +e+ +++++ ++l++++ + +e +l+H D+ e N++++e
  EFC39508.1 1032 LNMAHPNIIKVNDMFVDKNELLVIEMEYYDKGDLTSLLKVQiSETLLKSVLFQMLNALEYIHEEKKLIHRDVKESNIFIKE 1112
                  333444446676666667777776665555777777777776799********************************9976 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 2.2
                  HHHHHHHHHHHHHHHHHHHHTT--S--EEEEETTEEEEE--EETTEEGGBHHH CS
        RIO1   48 rklvklwaekEfrnLkrleeagvpvPkpielkrhvlvmefigedgvaapklkd 100 
                   ++++l   k  ++ k++ +++++ P+ +  +   lv e++g+d    p+ ++
  EFC39508.1 1179 TAISHLHFSKDSSQVKQILTENMQKPNIYSTELIELVIEMVGKDSATRPQARQ 1231
                  56777778888899999999999999999999999*******99988888765 PP

>> Stevor  Subtelomeric Variable Open Reading frame
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.4   5.2e-05     0.037     232     264 ..     893     924 ..     866     927 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 5.2e-05
      Stevor 232 afepygiaalvllilavvliiLYiwlyrRRKnS 264
                 ++ p  +++++l++++v+lii+ i+ +r++K+S
  EFC39508.1 893 TLVPI-LSVFLLIVIIVILIIILIFYFRKKKKS 924
                 44443.5778899999***************99 PP

>> FixQ  Cbb3-type cytochrome oxidase component FixQ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.2   5.4e-05     0.039       5      36 ..     893     924 ..     891     927 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 5.4e-05
        FixQ   5 alrgfadswgllflvllfygvviyafrpgnrk 36 
                 +l+ +   ++l++ ++++++++i+ fr++++ 
  EFC39508.1 893 TLVPILSVFLLIVIIVILIIILIFYFRKKKKS 924
                 77888899**********************86 PP

>> DPM3  Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1   0.00012     0.083      31      88 ..     885     942 ..     872     945 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 0.00012
        DPM3  31 skvqdevvpvlPlwalvlfGayslatlgygvltfndcpeaakeLqkeikeAkadLrkk 88 
                 ++++  ++ ++P++ ++l+ +  ++ +++ ++ f+ +++  ++L+ e++e k+d  + 
  EFC39508.1 885 ETQVVLIATLVPILSVFLLIVIIVILIIILIFYFRKKKKSNENLNLEMIESKNDITAT 942
                 45555668899******************************************99876 PP

>> PspB  Phage shock protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.4    0.0001     0.074       4      37 ..     897     930 ..     892     941 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 0.0001
        PspB   4 flavpliifvlfVapiWLiLHYrskkkrskglsa 37 
                 +l v l i+++++++i Li+++r+kkk++++l+ 
  EFC39508.1 897 ILSVFLLIVIIVILIIILIFYFRKKKKSNENLNL 930
                 5667778888888899999*********999975 PP

>> CD20  CD20-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   0.00015      0.11      52     122 ..     881     953 ..     879     969 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 0.00015
        CD20  52 ekrstkllvklslllnlvslvlalaGiillilslalltsaeelkesesdl..tsstsrcsskesseeeesray 122
                 +k++ + +v++ +l  ++s++l ++ i++li  l++++  ++  +++++l  ++s+++ + +  +e e s+++
  EFC39508.1 881 SKQQETQVVLIATLVPILSVFLLIVIIVILIIILIFYFRKKKKSNENLNLemIESKNDITATDFPESEASIFF 953
                 788889999****************************************977666666665555555555555 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.3   0.00021      0.15      95     166 ..    1053    1124 ..    1047    1140 .. 0.90

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00021
  YrbL-PhoP_reg   95 lvvekirdadGnvaktLedlvkkeeltaelkeaLdefleelldnhivtndlsakNivvkknsegeeelvlvD 166 
                     lv+e+     G++   L+  +++  l+  l + L+++     + + + +d++ +Ni++k+  ++  ++vl D
     EFC39508.1 1053 LVIEMEYYDKGDLTSLLKVQISETLLKSVLFQMLNALEYIHEEKKLIHRDVKESNIFIKELTQDYIQVVLAD 1124
                     7899999999***************************999999**********************9999998 PP

>> Ly49  Ly49-like protein, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.4   0.00039      0.28       6      46 ..     890     931 ..     887     960 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00039
                 XXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXX.XXXXXXX CS
        Ly49   6 livvalgILclllL.vtvavLvtkifqysqekheleetlnls 46 
                 li+  + IL ++lL v++++L++ ++ y ++k++ +e lnl+
  EFC39508.1 890 LIATLVPILSVFLLiVIIVILIIILIFYFRKKKKSNENLNLE 931
                 566777899766661555566666677889999999999975 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.3   0.00027       0.2      57      89 ..     880     913 ..     850     932 .. 0.46

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00027
       Orf78  57 aekaqalnilli.sllavvcvlvllyviyYfvil 89 
                 ++k+q+++++li +l+ +++v++l+ +i+  +i+
  EFC39508.1 880 SSKQQETQVVLIaTLVPILSVFLLIVIIVILIII 913
                 2333333333331333333333333333322222 PP

>> TMCCDC2  Transmembrane and coiled-coil domain-containing protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.1      0.62   4.5e+02      95     125 ..     572     602 ..     553     604 .. 0.74
   2 ?   10.0   0.7   0.00085      0.61      23      69 ..     878     924 ..     870     934 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.62
     TMCCDC2  95 lanpegaelkiqdnknlllslglqekilkkl 125
                 la + ++ + + +++nl+l  +lq k +k+l
  EFC39508.1 572 LAMSGNNLILYSQSENLVLQYNLQSKGVKNL 602
                 444555556667789***********99987 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00085
     TMCCDC2  23 getsvpqqtnlglldnlaptvqvilkiiflillaiGlyalwkrsirs 69 
                  e+s+ q+t+  l+  l p++ v l i+++++l+i l+  +++  +s
  EFC39508.1 878 PESSKQQETQVVLIATLVPILSVFLLIVIIVILIIILIFYFRKKKKS 924
                 578999*******************9999999988877666665555 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   4.8    0.0014      0.98       9      29 .]     851     872 ..     842     872 .. 0.91

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.0014
  EGF_Tenascin   9 RGvCvD.GqCiCDsEYsGDDCs 29 
                   RG Cv   qC C  +YsG++Cs
    EFC39508.1 851 RGQCVSpNQCNCTLNYSGNECS 872
                   9****747*************9 PP

>> ASFV_J13L  African swine fever virus J13L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   2.6   0.00098       0.7      33      62 ..     899     927 ..     888     946 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00098
   ASFV_J13L  33 tiliaivvliiiiivliylfssrkkkaaaa 62 
                 ++++ iv+++i+ii+li+ f  +k k+   
  EFC39508.1 899 SVFLLIVIIVILIIILIFYFRKKK-KSNEN 927
                 566778888888888998886544.44444 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9  12.6    0.0014      0.97       5      32 .]     843     871 ..     837     871 .. 0.91

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.0014
       EGF_2   5 deiCgg..hGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+g  +G+Cv+++ qC C  +y+G+ C
  EFC39508.1 843 SDACNGieRGQCVSPN-QCNCTLNYSGNEC 871
                 789**********999.************* PP

>> MRJP  Major royal jelly protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.0      0.39   2.8e+02     172     215 ..     259     304 ..     196     328 .. 0.68
   2 ?    8.4   0.2    0.0017       1.3      77     105 ..     347     375 ..     325     392 .. 0.81
   3 ?   -2.1   0.0       2.6   1.9e+03      76      94 ..     401     419 ..     385     421 .. 0.81
   4 ?   -0.8   0.4       1.1     8e+02     117     252 ..     927    1055 ..     917    1066 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.39
        MRJP 172 vsyeefkdlgkrg..sqstakavdkngvlffglvnesaivcwnesk 215
                 +  ++f ++ +    +++ + avd +g++++++   + +++ ++s+
  EFC39508.1 259 SLGQGFVYMAETQllTACRGIAVDLEGNIYMSESYANRVLKLDIST 304
                 3445555555555668899999999999999999888888888776 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0017
        MRJP  77 tfvYiaDakgkgliVYdladdkswRvesn 105
                    Yi+D+ ++++i Y++++d+ +Rv  n
  EFC39508.1 347 QSLYISDSNNHRVIRYNISSDTVYRVAGN 375
                 458**********************9866 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 2.6
        MRJP  76 dtfvYiaDakgkgliVYdl 94 
                 +++ Yi+D++++++ ++++
  EFC39508.1 401 NGILYISDTGNRRIRIVSN 419
                 5899********9988775 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 1.1
        MRJP  117 tiagesfqlkdGifglalspvtndgrtLYFhplaSeklysVptevLrneslaenn.vsyeefkdlgkrgsqstakavdkngvlffglvnesaivcwn 212 
                  +++ e ++ k+ i ++++ +++   + ++F p+  ++  s +t+   ++s + +  +  +++ ++g+ g  s+ +a+d +++ f + ++  +  ++ 
  EFC39508.1  927 NLNLEMIESKNDITATDFPESE---ASIFFRPTMEFQSVSSSTNGTSSSSSSFDPlSRFKDMVKIGSGGFGSVFRAFDVKTNSFKA-LKAIKFQSYS 1019
                  5666677777777777774433...5699999998888888888877777777776677788888887799999999999998755.5566889999 PP

        MRJP  213 eskpysrenlktvarneetlqfvsdlkideregeeelwvL 252 
                  e +++ +e l+ +++   +++ v+d+ +d+    +el+v+
  EFC39508.1 1020 ELNQFMKEGLQLLNMAHPNIIKVNDMFVDK----NELLVI 1055
                  999999999999999999999999999999....566665 PP

>> SKG6  Transmembrane alpha-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   8.4     0.025        18      21      38 .]     904     921 ..     903     921 .. 0.92

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.025
        SKG6  21 aViiivLlailifvrRRk 38 
                 +Vii++L++ilif+ R+k
  EFC39508.1 904 IVIIVILIIILIFYFRKK 921
                 8**************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1239 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1325  (0.0739026); expected 358.6 (0.02)
Passed bias filter:                      773  (0.0431145); expected 358.6 (0.02)
Passed Vit filter:                       157  (0.00875676); expected 17.9 (0.001)
Passed Fwd filter:                        26  (0.00145016); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              25  [number of targets reported over threshold]
# CPU time: 1.04u 0.36s 00:00:01.40 Elapsed: 00:00:00.51
# Mc/sec: 7367.20
//
Query:       EFC39509.1  [L=1200]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      0.006   16.2   2.2      0.016   14.8   2.2    1.7  1  Exonuc_VII_L  Exonuclease VII, large subunit
  ------ inclusion threshold ------
      0.017   14.5   0.8      0.017   14.5   0.8    2.7  2  FliD_C        Flagellar hook-associated protein 2 C-terminus
      0.065   14.1   0.5      0.065   14.1   0.5    7.9  7  zf-C2H2_4     C2H2-type zinc finger
      0.077   12.7   0.0       0.18   11.5   0.0    1.6  1  PGAP1         PGAP1-like protein
       0.38   11.4   2.5       0.67   10.6   0.9    2.3  2  SlyX          SlyX
        6.8    7.2  15.8         13    6.3   4.9    2.9  2  ZapB          Cell division protein ZapB


Domain annotation for each model (and alignments):
>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   2.2   5.3e-06     0.016     141     218 ..      79     162 ..      74     278 .. 0.71

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.3e-06
  Exonuc_VII_L 141 dkaeleeqleelerrlekaikrlleekkqrleklasrlkspeellerkrqrldeleerleralkkq........lkkkrerleelk 218
                   d  +l e+l++++   +++ +++l ++k ++ekl++++++ +++l+r++++ld+lee+l++ ++++        +  + e+l+e +
    EFC39509.1  79 DCYQLYEKLRHMTTTKSNNSDEKLIKQKDQIEKLRKKVSQLKSMLTRREEKLDSLEEKLSKIHHHKlvklviaaI--EDEKLHEQQ 162
                   556788999999999999999***************************************955555666655331..222222222 PP

>> FliD_C  Flagellar hook-associated protein 2 C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.5   0.8   5.8e-06     0.017     168     238 ..      71     137 ..      27     139 .. 0.83
   2 ?   -1.4   1.1      0.42   1.3e+03      49      89 ..     975    1013 ..     973    1020 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 5.8e-06
                 ..SXSHHHHHHHHHHHHHSTT.SHHHHHHHHXXXXHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH CS
      FliD_C 168 tsdsglatrlenllksyvkssngtlqtasknltkqikdldkkiedldkrletleerlkkqfaalekavskl 238
                  + +g+ t+ ++l +++       ++t+s+n ++++ + +++ie+l k++++l+++l+++ ++l+++ +kl
  EFC39509.1  71 LNRNGVCTDCYQLYEKLRHM----TTTKSNNSDEKLIKQKDQIEKLRKKVSQLKSMLTRREEKLDSLEEKL 137
                 46778888877777776644....489**************************************998876 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.42
                  SCCCCCCHCHHHHHHHHCCCCCCCCCS..-----XXXXXXX CS
      FliD_C   49 tdkikealkeFVdaYNalvteinektkekedeikdeekaks 89  
                  + ++ + l++F d  N+ + +i+e +k    +i+++ k+++
  EFC39509.1  975 VIGLFNILNKFFDDVNTAISNIQEFSKT--SNIEKKRKKSN 1013
                  5566777899999999999999998884..34444333332 PP

>> zf-C2H2_4  C2H2-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       2.6   7.7e+03       6      20 ..      77      90 ..      75      92 .. 0.51
   2 ?   14.1   0.5   2.2e-05     0.065       3      24 .]     702     723 ..     700     723 .. 0.96
   3 ?   -0.7   0.5       1.2   3.7e+03       9      24 .]     922     938 ..     920     938 .. 0.72
   4 ?   -2.5   3.4       4.6   1.4e+04       2      14 ..    1072    1084 ..    1071    1089 .. 0.81
   5 ?  -12.9  13.8         6   1.8e+04       3       3 ..    1117    1117 ..    1102    1141 .. 0.58
   6 ?   -3.1   4.5         6   1.8e+04       1      14 [.    1144    1155 ..    1144    1163 .. 0.75
   7 ?   -5.7   2.6         6   1.8e+04       2       9 ..    1166    1172 ..    1165    1180 .. 0.62

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.6
   zf-C2H2_4  6 CgksFsskkaLlrHl 20
                C+  +   ++ lrH+
  EFC39509.1 77 CTDCY-QLYEKLRHM 90
                55555.333346666 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 2.2e-05
   zf-C2H2_4   3 CpiCgksFsskkaLlrHlkthH 24 
                 C+ C+++F + k++l+H+ ++H
  EFC39509.1 702 CKECNQPFVRLKSFLKHVMNVH 723
                 *******************999 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 1.2
   zf-C2H2_4   9 sFsskkaL.lrHlkthH 24 
                 +F ++ +L ++H   hH
  EFC39509.1 922 VFVDSLKLmKSHKDLHH 938
                 67766665277*****9 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 4.6
   zf-C2H2_4    2 kCpiCgksFsskk 14  
                  kC  C + F++++
  EFC39509.1 1072 KCGDCFRLFCDSC 1084
                  7********8765 PP

  == domain 5  score: -12.9 bits;  conditional E-value: 6
   zf-C2H2_4    3 C 3   
                  C
  EFC39509.1 1117 C 1117
                  2 PP

  == domain 6  score: -3.1 bits;  conditional E-value: 6
   zf-C2H2_4    1 fkCpiCgksFsskk 14  
                  f C+ C   F++++
  EFC39509.1 1144 FVCESC--HFRTQS 1155
                  78****..996654 PP

  == domain 7  score: -5.7 bits;  conditional E-value: 6
   zf-C2H2_4    2 kCpiCgks 9   
                  +C+ C   
  EFC39509.1 1166 ICDSC-VK 1172
                  69999.33 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   5.9e-05      0.18      28     112 ..     302     390 ..     290     400 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5.9e-05
       PGAP1  28 aeayqelrkllknqnkke.ldfftvdfneelsa...ldGrtlldqaeylndaIkyIlslysssekeptsviliGHSmGGivaraaltlk 112
                 ++ y+++++ +++q +++  +ff+   +  +s+   + G t + +a++l+d +k+I ++++  + ++ s  ++G S  G+   ++++  
  EFC39509.1 302 DQLYKSKEEIVPSQIASHiCQFFATTIDGSVSFplmFAGCTKSSHADFLEDQVKKIKEQFERIQLNNYSFQVVGFSSDGLTGNLTFFQT 390
                 45677789999999999988**********99655589**************************************9999887776654 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.9   0.00022      0.67      10      49 ..     100     139 ..      80     147 .. 0.81
   2 ?   -2.1   0.0       2.1   6.3e+03      34      51 ..     348     365 ..     344     370 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00022
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XX CS
        SlyX  10 iklafqedtieeLndvvaeqqqqidrlqrqlrllaerlke 49 
                 +kl  q d+ie+L + v +    ++r +++l+ l+e+l++
  EFC39509.1 100 EKLIKQKDQIEKLRKKVSQLKSMLTRREEKLDSLEEKLSK 139
                 5677788888888888888888888888888888888765 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 2.1
                 HHHHHHHHHHHHT-XXXX CS
        SlyX  34 drlqrqlrllaerlkele 51 
                 d l+ q+++++e+++ ++
  EFC39509.1 348 DFLEDQVKKIKEQFERIQ 365
                 667888888888887666 PP

>> ZapB  Cell division protein ZapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   4.9    0.0044        13      18      52 ..     107     141 ..     100     176 .. 0.84
   2 ?    5.4   3.1    0.0084        25      23      65 ..     620     662 ..     618     667 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0044
        ZapB  18 dtitlLqmeieeLkeeneelkeenreleeeneqlk 52 
                 d+i++L++++++Lk      +e+ + lee++++  
  EFC39509.1 107 DQIEKLRKKVSQLKSMLTRREEKLDSLEEKLSKIH 141
                 89**************************9998875 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0084
        ZapB  23 LqmeieeLkeeneelkeenreleeeneqlkeereawqerlkkL 65 
                 L  e+eeL +++++ k++++  eee +q  e  ++++e  + +
  EFC39509.1 620 LELEYEELTRKKYKKKNKKKLTEEEEDQILEKENSFTEMFDYI 662
                 788***********************99999999888766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1200 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2403  (0.134029); expected 358.6 (0.02)
Passed bias filter:                      615  (0.034302); expected 358.6 (0.02)
Passed Vit filter:                        96  (0.00535445); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.99u 0.36s 00:00:01.35 Elapsed: 00:00:00.53
# Mc/sec: 6771.71
//
Query:       EFC39510.1  [L=366]
Description: hypothetical protein NAEGRDRAFT_81271 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.071   13.0   0.3      0.071   13.0   0.3    1.9  2  FWWh           Protein of unknown function
      0.074   13.6   0.0      0.087   13.4   0.0    1.3  1  Abhydrolase_6  Alpha/beta hydrolase family


Domain annotation for each model (and alignments):
>> FWWh  Protein of unknown function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.2      0.34   3.1e+03      60      83 ..     144     168 ..     115     186 .. 0.60
   2 ?   13.0   0.3   7.9e-06     0.071       5      54 ..     239     288 ..     236     324 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.34
        FWWh  60 keeqdklfnriaen.YvkLllkvqr 83 
                 ++++d++++r a   Y +   ++q+
  EFC39510.1 144 RQSRDHVLSRSASVwYSNYVKEQQQ 168
                 3334555555554412333333333 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 7.9e-06
        FWWh   5 PnevelkkildkvlraqkfkkklkkelkklllseeskallldsFWwffle 54 
                  +++++ + + kvlr+ ++++++ +++ +++ s+  ++++  sFWw    
  EFC39510.1 239 ARDLKFLHPMAKVLRSYPEEPTIVEQFMNHVESDGWDEVFAKSFWWAQDS 288
                 57788888999***********************************7554 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   9.7e-06     0.087       1      81 [.      89     196 ..      89     355 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 9.7e-06
                    EEEE--.GC.....GC..HHHHHHHHCCTCEEEEE--TTST.................S-GGCS--HHH.CHHH..HHHHCCTT...........T CS
  Abhydrolase_6   1 vlllHG.agssassWl..vapLaallaagvhvlapDlpGhG.................rsdpppldled.ladl..aalldelaa.........gg 64 
                    v+l+HG +g+ as+++     L + +  +v  l + +p++                  r  ++++ l++ +  +  ++++ e  +          +
     EFC39510.1  89 VVLCHGcFGF-ASQFFfiEKKLIESGKFRV--LNYWYPSYRqsiersssglydflnehR-QSRDHVLSRsA-SVwySNYVKEQQQqetsdeisnED 179
                    89****5443.4555424667777777774..555555553233322222333333321.22222222221.111222222222244445555477 PP

                    TSEEEEEETCHHHHHHH CS
  Abhydrolase_6  65 gpvvlvGHSlGGalala 81 
                      ++ v HS+G +++  
     EFC39510.1 180 ESFHFVTHSMGSMIVRN 196
                    888**********9877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       708  (0.0394891); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.44u 0.20s 00:00:00.64 Elapsed: 00:00:00.34
# Mc/sec: 3227.41
//
Query:       EFC39511.1  [L=349]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.2e-12   46.9   0.9    2.2e-12   46.9   0.9    2.5  3  Prefoldin    Prefoldin subunit
    0.00045   20.2   0.8    0.00045   20.2   0.8    3.0  2  Prefoldin_3  Prefoldin subunit
  ------ inclusion threshold ------
       0.29   10.5   8.4       0.11   11.9   3.3    2.2  2  PMSI1        Protein missing in infertile sperm 1, putative


Domain annotation for each model (and alignments):
>> Prefoldin  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.9   0.9   3.7e-16   2.2e-12      16      95 ..      34     121 ..      18     133 .. 0.77
   2 ?   -2.5   1.7       0.8   4.8e+03      81     114 ..     141     172 ..     137     178 .. 0.58
   3 ?   -1.7   0.1      0.44   2.6e+03      19      34 ..     211     226 ..     206     242 .. 0.65

  Alignments for each domain:
  == domain 1  score: 46.9 bits;  conditional E-value: 3.7e-16
                 HHHHHHHHHHHHHHHHHTT.......-TT-EEEEEEE..TTEEEEEE--STTEEEEEEETTEEEEEEHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  16 keaieelektletlktlkk......edegkevlvplg..aglyvkaevkdtdkvlvdlGagyyveksleeAiellkkkleelekqlek 95 
                 ++ai ++ektle  k+l k      +   +  ++p+g  + ++++++++ t++++v+lG++y+++ s+ +A e+lk++++++ + le+
  EFC39511.1  34 RKAIQDYEKTLEEYKELYKtltfipQSLKQSCMIPIGthQLAFMPGQLVQTNEITVSLGENYFIKTSAYQAREILKRRIKKVMEKLEQ 121
                 344555555555555555555555558888889998833569*************************************998888776 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 0.8
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  81 llkkkleelekqlekleeeleklkdqittleanl 114
                 +lk++ ++ ++  e+++++ e   ++++++ +++
  EFC39511.1 141 ILKEEQKKSKREEEEYQDMSEA--TKLEQMFREM 172
                 6777777777777777776553..2333333333 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.44
                 HHHHHHHHHHHHHHTT CS
   Prefoldin  19 ieelektletlktlkk 34 
                  ++ e++le+l++l+ 
  EFC39511.1 211 RKDEEDILEILEELER 226
                 5566777777777777 PP

>> Prefoldin_3  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.8   7.5e-08   0.00045       2      89 ..      35     124 ..      17     131 .. 0.73
   2 ?   -0.2   2.7      0.17     1e+03       7      55 ..     142     189 ..     136     231 .. 0.75

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 7.5e-08
  Prefoldin_3   2 kslyklreweaeydglkeeisalkeeddateedllriard...f.egslvtekEveeilGekqgvtrskqQvvdlisrRiDYVkqniktlek 89 
                  k +++++++ +ey++l + ++ +++  + +++ ++ i+     f  g+lv+ +E+ + lGe+  ++ s+ Q  ++++rRi  V + ++   k
   EFC39511.1  35 KAIQDYEKTLEEYKELYKTLTFIPQ--SLKQSCMIPIGTHqlaFmPGQLVQTNEITVSLGENYFIKTSAYQAREILKRRIKKVMEKLEQERK 124
                  3445555555555555555555544..55555555555432225369*********************************999888776555 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.17
  Prefoldin_3   7 lreweaeydglkeeisalkeeddateedllriardfegslvtekEveei 55 
                  l+e +++ ++ +ee+++++e  +  e+ +++++ + +gsl +  E+e+i
   EFC39511.1 142 LKEEQKKSKREEEEYQDMSE-ATKLEQMFREMEMNSNGSLPDFSEMEDI 189
                  66667777777788888855.4555566777777777777777777665 PP

>> PMSI1  Protein missing in infertile sperm 1, putative
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1     0.054   3.2e+02     118     182 ..      13      78 ..       2      79 .. 0.62
   2 ?   11.9   3.3   1.9e-05      0.11      29     166 ..     200     339 ..     192     346 .. 0.68

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.054
       PMSI1 118 anaqeaeirltsslpkstlkstedelasektlskwstaGstpsrwp.kpsptalpppedlrlvLlp 182
                 +n+  ++ +l  + ++ +l+  +  + +ektl++++ +  t +  p ++ ++ + p    +l  +p
  EFC39511.1  13 NNNNLNKKELERQFTEVALRHRKAIQDYEKTLEEYKELYKTLTFIPqSLKQSCMIPIGTHQLAFMP 78 
                 222222334556677888899999999999999999998877654414556777777666776665 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 1.9e-05
       PMSI1  29 rtdlprktrvtledeeDavaeadrLagPaaaeLLastvatgisksklsqieedgsleegvvinarkndtesesestssstagssss..rfaanaqeaei 125
                 r +l  + + t  deeD+    ++L    a ++    v+ +++k+ +++ +e+++ ee      +k  ++   ++ ++ t g+s+   +  +++q++  
  EFC39511.1 200 RDELYYRHKTTRKDEEDILEILEELEREEATDMKKGGVNINLNKHIEEEEDEEDEGEEFGE--EEKRLQQDILKYFHRATGGASTEpkQQPKKSQQPPK 296
                 66688899*****************************999999998887544444444443..334333333334444444444334466677888876 PP

       PMSI1 126 rltsslpkstlk..stedelasektlskwstaGstpsrwpkps 166
                 + +s ++ +t+    ++d l+s++++ k s   +t ++++k+s
  EFC39511.1 297 QSSSTMKDTTSFniVERDALPSQSSIFKASPGNTTHEQPKKVS 339
                 6666666665543456788888888888776666666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (349 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2135  (0.119081); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2254.49
//
Query:       EFC39512.1  [L=849]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.6e-68  231.2   1.5    1.6e-68  231.2   1.5    1.7  2  Glyco_hydro_44  Glycoside hydrolase family 44
    8.5e-21   74.0  66.3    7.7e-05   23.0   7.5    5.4  5  EGF_2           EGF-like domain


Domain annotation for each model (and alignments):
>> Glyco_hydro_44  Glycoside hydrolase family 44
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  231.2   1.5   1.7e-72   1.6e-68       2     234 .]      85     328 ..      84     328 .. 0.95
   2 ?   -2.1   0.1      0.34   3.1e+03      19      51 ..     482     514 ..     461     548 .. 0.70

  Alignments for each domain:
  == domain 1  score: 231.2 bits;  conditional E-value: 1.7e-72
                     EE-GGGTTT.................EEESHHHHHTT--GGEEEEE--SSEEES--.SE..E--GG....G-SSSTTEEE............... CS
  Glyco_hydro_44   2 snagsDWyfeniased.........sssdefletnkkagaksllTvpligyvakdkasg..sfseskygeqaapdsrwke.......dagngvas 78 
                     +n+++DW+f+ni++e          s++++f++t++k+g+k +lT +ligy++ d++s+  +fs++kyg+q +++++ +        dagng+++
      EFC39512.1  85 HNTAQDWFFMNIPDEIesgqilpngSAATMFMDTANKHGSKLMLTASLIGYTPLDDRSKkwGFSVAKYGSQLETECTRTGfpswcmgDAGNGKKT 179
                     7***********9887999*****9999***************************999999***************6665999999999999998 PP

                     ..EES--SS---SS--SSSSEEEHHH.....HHHHHHHHH--TSTTS--EEEESS-GGGHHHH-TTT--S---HHHHHHHHHHHHHHHHHH-TT- CS
  Glyco_hydro_44  79 dgvkikktaelsltpdptdtsvyadeeftkewvnhlvkklgsasatgvkfysLDNEpelWssTHrdvhpekvtydellertidlAkavkaadpda 173
                     ++ ++  t     ++dp++ts+ +de+++ +w+++++++      t vk++sLDNE++lW+sTH+dvhp+++tyde+++ t ++Aka+k+ d+++
      EFC39512.1 180 GNIYV--T-----GNDPAETSKVIDENYVVNWIKYMKSRG-----TPVKLWSLDNEMDLWHSTHHDVHPNPITYDEMWTLTEKYAKAIKTEDSTI 262
                     88888..6.....89**********************994.....79************************************************ PP

                     EEEEEEE-SHHHHTTT-.......TTCT..T-SSHHHHHHHHHHHHHHHHTS-S-SEEEEEE---- CS
  Glyco_hydro_44 174 evlGpaswgwtayfqsaa.....epdkaahgnvwfldyyLdqmkeaekkaGkRlLDvldlHyYpqa 234
                     +++Gp+swg+++y++s a      +d++ah+n +++dyyL++++e++k++G  l+D+ld+HyYpqa
      EFC39512.1 263 KTFGPNSWGHCGYYYSPAdgcssGADRQAHSNLPLIDYYLTKVCEYKKNTGILLVDYLDIHYYPQA 328
                     ****************9889988899**************************************96 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.34
                     EEESHHHHHTT--GGEEEEE--SSEEES--.SE CS
  Glyco_hydro_44  19 ssdefletnkkagaksllTvpligyvakdkasg 51 
                     s++ ++  ++k  ++s + ++l+g v k+k+ +
      EFC39512.1 482 SNTLYIVLVNKLTSASSVSLQLAGDVGKSKSIT 514
                     555577778888888999999999999988554 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   6.0   8.7e-08   0.00078       6      32 .]     581     606 ..     576     606 .. 0.85
   2 !   18.8   7.1   1.7e-07    0.0016       6      32 .]     629     654 ..     624     654 .. 0.85
   3 !   18.3   6.3   2.5e-07    0.0023       6      32 .]     671     696 ..     667     696 .. 0.86
   4 !   23.0   7.5   8.6e-09   7.7e-05       6      32 .]     716     741 ..     712     741 .. 0.87
   5 !   19.3   7.4   1.2e-07    0.0011       6      32 .]     764     789 ..     759     789 .. 0.85

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 8.7e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g G+C +    C Cd++++G++C
  EFC39512.1 581 AVCSGFGKCLKND-TCTCDASHSGAKC 606
                 57*******7444.7************ PP

  == domain 2  score: 18.8 bits;  conditional E-value: 1.7e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+g G+C +    C Cds+++G +C
  EFC39512.1 629 AVCSGFGKCLKND-TCTCDSSHTGSKC 654
                 57*******7444.7************ PP

  == domain 3  score: 18.3 bits;  conditional E-value: 2.5e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g GtC +    C Cds+++G +C
  EFC39512.1 671 SVCSGFGTCLKND-TCTCDSKHTGVKC 696
                 57*******7444.7************ PP

  == domain 4  score: 23.0 bits;  conditional E-value: 8.6e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g GtCv+ ++ C Cds+++G++C
  EFC39512.1 716 SVCSGFGTCVK-NNTCTCDSKHTGAKC 741
                 57*******94.459************ PP

  == domain 5  score: 19.3 bits;  conditional E-value: 1.2e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g GtC +    C Cds+++G++C
  EFC39512.1 764 TVCSGFGTCLKND-TCTCDSKHTGAQC 789
                 67*******7444.7************ PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (849 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       728  (0.0406046); expected 358.6 (0.02)
Passed bias filter:                      338  (0.0188521); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.82u 0.33s 00:00:01.14 Elapsed: 00:00:00.56
# Mc/sec: 4552.47
//
Query:       EFC39513.1  [L=115]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.1e-05   24.6   6.3    5.3e-05   23.3   6.3    1.6  1  Pmp3        Proteolipid membrane potential modulator
  ------ inclusion threshold ------
      0.041   14.0   0.0      0.055   13.6   0.0    1.2  1  DUF872      Eukaryotic protein of unknown function (DUF872)
       0.26   11.1   1.4       0.45   10.4   0.2    1.8  2  Flavi_NS2B  Flavivirus non-structural protein NS2B


Domain annotation for each model (and alignments):
>> Pmp3  Proteolipid membrane potential modulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.3   6.3   8.9e-09   5.3e-05       2      48 ..      51     108 ..      50     109 .. 0.82

  Alignments for each domain:
  == domain 1  score: 23.3 bits;  conditional E-value: 8.9e-09
        Pmp3   2 illillaiilPPlaValk..........sG.csadllinilLtllgylPgviHAfyii 48 
                 ++l+  ai++PPla  +           +G    +++++  Lt+l+y+Pg++H ++ i
  EFC39513.1  51 LMLLTTAILFPPLAMGILlrfhlkhpmeKGeKVRQIVVCAMLTMLCYVPGLLHVIFAI 108
                 577788*********99856767666666655556******************99988 PP

>> DUF872  Eukaryotic protein of unknown function (DUF872)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   9.2e-06     0.055      40      99 ..      41     109 ..      10     113 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 9.2e-06
      DUF872  40 kknrkvvlaallLlllGlvL..lllgvvilvep....seGvssavf...lvlGlllfiPGvYhvvyiyl 99 
                  +n  +   +l+Ll++ ++   l++g+++  +      +G++        +l +l+++PG+ hv+++ l
  EFC39513.1  41 DENSGSSSCSLMLLTTAILFppLAMGILLRFHLkhpmEKGEKVRQIvvcAMLTMLCYVPGLLHVIFAIL 109
                 4555566666666666665533455555443212244567665433233678899**********9876 PP

>> Flavi_NS2B  Flavivirus non-structural protein NS2B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.2   7.6e-05      0.45      32      71 ..      12      50 ..       6      60 .. 0.76
   2 ?   -0.7   0.1       0.2   1.2e+03      26      43 ..      83     100 ..      63     104 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 7.6e-05
  Flavi_NS2B 32 GGllialvvvaGrvddlelkklaevsweeeaeisGasari 71
                GG++i+ +  +  ++d e++k+ + s  +e e sG+s+  
  EFC39513.1 12 GGVVIVNIP-SSASSDDEIRKAKNSSSRKEDENSGSSSCS 50
                555555544.44555669******************9865 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.2
  Flavi_NS2B  26 lGPlivGGllialvvvaG 43 
                 +  ++v  +l +l  v G
  EFC39513.1  83 VRQIVVCAMLTMLCYVPG 100
                 445777777777766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (115 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       679  (0.0378716); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 628.70
//
Query:       EFC39514.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.066   13.2   0.1      0.094   12.7   0.1    1.3  1  FGAR-AT_N  Formylglycinamide ribonucleotide amidotransferase 
      0.098   12.3   2.0       0.13   12.0   2.0    1.1  1  Syntaxin   Syntaxin


Domain annotation for each model (and alignments):
>> FGAR-AT_N  Formylglycinamide ribonucleotide amidotransferase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1   1.1e-05     0.094      19      62 ..      89     144 ..      77     167 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.1e-05
   FGAR-AT_N  19 vleqlLeygdkleeeeeege............lllVvPRlGtiSpWsSkAtdIahn 62 
                  le+lL+ ++++++++++++            +l V+P + t S + S A+  a  
  EFC39514.1  89 FLENLLQSNSNANTAQPKKNkqskrtkrssadVLAVIPQTTTSSYYTSAASTTAFA 144
                 68889988888555554444456677777888****************99876655 PP

>> Syntaxin  Syntaxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   2.0   1.4e-05      0.13      24      98 ..      49     124 ..      43     141 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 1.4e-05
    Syntaxin  24 klkkqneesktstraksvk.lkkrmesdikeikkraesvkarLeaLdksnkenekks.gegsavdRirksqtaaLrk 98 
                 +l+ + +++  +t+++s+k  k++ + d+++i+  +  v + Le+L +sn ++++ + ++++ ++R+++s +++L  
  EFC39514.1  49 ELGTTDSDISMKTDSNSSKkRKRKGSMDVTNIEDDS-MVCSFLENLLQSNSNANTAQpKKNKQSKRTKRSSADVLAV 124
                 566777777788888888878999999999998876.566789999888876665555************9999975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1409  (0.0785878); expected 358.6 (0.02)
Passed bias filter:                      317  (0.0176809); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 1090.53
//
Query:       EFC39515.1  [L=498]
Description: acyl-CoA thioester hydrolase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.9e-13   48.3   0.0    3.1e-05   24.2   0.0    2.4  2  4HBT      Thioesterase superfamily


Domain annotation for each model (and alignments):
>> 4HBT  Thioesterase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.0   1.2e-08   0.00021       7      74 ..     139     212 ..     138     216 .. 0.92
   2 !   24.2   0.0   1.7e-09   3.1e-05       2      74 ..     367     438 ..     366     441 .. 0.79

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 1.2e-08
                 HHHHHHHHHHHHHHHHHTTST......TEEEEEEEEEEEESS-BBTTCEEEEEEEEEEEESSEEEEEEEEEETT CS
        4HBT   7 GvylallDeaagaalrslggr......gilvvvvelsidflrpvrlgdeltvearvlrlgrtsavvevevrded 74 
                 G++l+ lD  ag+++ ++ ++       ++v+++ ++i+  +p+ +  +l++ ++v+ +g++s+++++ev++ +
  EFC39515.1 139 GRLLEDLDALAGEVAYKHSDGfdkrrpLTIVTAAIDRIELQKPIIPFFDLEIVGKVTCTGKSSMEIRIEVHSLK 212
                 6777779999*********99**********************777779*********************9865 PP

  == domain 2  score: 24.2 bits;  conditional E-value: 1.7e-09
                 SSB-HHHHHHHHHHHHHHHHHHTTSTTEEEEEEEEEEEESS-BBTTCEEEEEEEEEEEESSEEEEEEEEEETT CS
        4HBT   2 GvvhgGvylallDeaagaalrslggrgilvvvvelsidflrpvrlgdeltvearvlrlgrtsavvevevrded 74 
                 G ++gG +l+ + e + + +    ++ + v+ +  +  flrpv +g++++++ +++++g +s+++++e++  d
  EFC39515.1 367 GKIFGGFLLKEAYELGFLTAYMFTKH-KPVFLALNENSFLRPVEVGSVVEFTSQIVYAGEKSLEIRCEIWVLD 438
                 56666666666666666666666666.66666666678********************************766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (498 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       696  (0.0388198); expected 358.6 (0.02)
Passed bias filter:                      460  (0.0256568); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 3200.32
//
Query:       EFC39516.1  [L=235]
Description: membrane protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.9e-21   74.5  11.7    1.6e-20   73.8  11.7    1.3  1  DUF2306   Predicted membrane protein (DUF2306)


Domain annotation for each model (and alignments):
>> DUF2306  Predicted membrane protein (DUF2306)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   73.8  11.7   9.1e-25   1.6e-20       2     146 ..      69     222 ..      68     223 .. 0.96

  Alignments for each domain:
  == domain 1  score: 73.8 bits;  conditional E-value: 9.1e-25
     DUF2306   2 vlHialalvalllGalqlvkrlrak.rpklHrlaGrvyvlavllaalsglflsvyatgglvlllgflllallwlvftvlalvairrrdfaaHrawmirs 99 
                 + H+++++v+ +l+++ql+  +r+    k+H+l+G++++++++++ +s++ l   + +g++  l   ++a+ +lv +++++ ++rr+dfaaHr+w  r 
  EFC39516.1  69 LGHVVCGGVVFVLSPFQLLGVMRKMvGGKVHKLLGQITFVSAVVSVISSILLVLTSKMGILCQLATFVFAPYTLVCIYKSFESARRKDFAAHREWACRM 167
                 78*********************9999************************************************************************ PP

     DUF2306 100 Yalalaavtlrlvllvlil........lvgedfetayavlsllawvpnlvvaell 146
                 +al+++++  r+++ ++          lv+ + +++ a   +++wv + ++ e++
  EFC39516.1 168 WALCFGVFYMRILVTIAKNvlcapdawLVTATAHKLFAFEFIAGWVTSCLFVEWY 222
                 ************98887767999*9999999999999***********9999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (235 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       707  (0.0394333); expected 358.6 (0.02)
Passed bias filter:                      285  (0.015896); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.44u 0.25s 00:00:00.69 Elapsed: 00:00:00.41
# Mc/sec: 1700.87
//
Query:       EFC39517.1  [L=1002]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.5e-29  102.2   0.0    5.6e-29  101.1   0.0    1.5  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    1.6e-05   24.8   3.9    8.8e-05   22.4   3.9    2.3  1  dCache_1       Cache domain
     0.0011   18.9   0.1     0.0029   17.6   0.1    1.7  1  TPR_2          Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.033   14.0   0.1       0.11   12.4   0.1    1.9  1  TPR_1          Tetratricopeptide repeat
      0.074   12.6   0.0       0.14   11.7   0.0    1.3  1  TBK1_CCD1      TANK-binding kinase 1 coiled-coil domain 1
        0.7   10.1   2.5       0.38   10.9   0.3    1.7  2  TPR_9          Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  101.1   0.0   1.9e-32   5.6e-29       7     174 ..     724     899 ..     721     908 .. 0.85

  Alignments for each domain:
  == domain 1  score: 101.1 bits;  conditional E-value: 1.9e-32
  Guanylate_cyc   7 devtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLd....mlealeevaveske 98 
                     + ti+F+dI++ft++s++ +p+++++ + e++  + e +  ++++ +k+iGd+ m+  g+p+ +a    + ++ aL     m +  ++ + e k+
     EFC39517.1 724 GNLTIFFSDIENFTTISEELDPEMLIQHVSEYFHVLTEEIIYENGTLDKYIGDSVMAFWGAPDTSAISGLRGCRAALRcqqrMSDLRRKWQREAKP 819
                    689***********************************************************6666665566666665000055555666677799 PP

  Guanylate_cyc  99 glkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgk..agkiqvseetyellk.eeqfeltergevevkGkg 174
                     ++ r+G+h+G++v+g iG   + +++++G++vnlAsr+e t k  +  i +se+t  +    eq e++++++++vkGk+
     EFC39517.1 820 LFRCRIGLHSGSCVVGNIGsIWRLNFTIIGDSVNLASRLEGTNKfyGTSILLSEDTFLQPYvAEQLEVRKIDQISVKGKS 899
                    9******************889********************993355677799998877789***************75 PP

>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   3.9   2.9e-08   8.8e-05      54     181 ..     374     499 ..     267     501 .. 0.84

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 2.9e-08
    dCache_1  54 easreslqallksilksnpdisgvylvdadGqviassdpssppnlegtddpadrdwykealaggggkpvisdpy...vdqt.ggkpvitiavpiyd.ds 147
                 e   +++q+ +   ++ ++ ++++y++++ G++ +++d +   +     dp++ ++yk al+ ++   v  d+    +  + + + ++ + + +y+ ++
  EFC39517.1 374 EGQFDNMQRVFLMKQANDETFQSFYYFSKYGKLRTVTDSELMDKW----DPTQGEFYKLALKHKE-ALVPMDVQwqgS--SiEERIYTCYQSNVYSpYD 465
                 444566666666666777999************998776666555....9**************8.676677766443..35699************88 PP

    dCache_1 148 gkfiGvlaadldldnlqdllsniklgetgyvfiv 181
                  +f+G+  +++++ +l+d+++++ ++++++v iv
  EFC39517.1 466 STFLGMTSINVNIKYLSDFVRSFYVSPNSFVAIV 499
                 9**********************99999999998 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.1   9.6e-07    0.0029       5      34 .]     943     972 ..     941     972 .. 0.95

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 9.6e-07
       TPR_2   5 ynlGlayyklgdyeeAleafekAleldPnn 34 
                 y+++l  y++gd+++Al +fe++l++ P++
  EFC39517.1 943 YERALEMYASGDFAQALLFFEECLKIRPED 972
                 899*************************86 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.1   3.7e-05      0.11      12      34 .]     950     972 ..     941     972 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.7e-05
                 HHTT-HHHHHHHHHHHHHHSTTH CS
       TPR_1  12 fklgkydeAleyyekALelnPnn 34 
                 +  g++ +Al ++e++L+++P++
  EFC39517.1 950 YASGDFAQALLFFEECLKIRPED 972
                 778******************86 PP

>> TBK1_CCD1  TANK-binding kinase 1 coiled-coil domain 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   4.6e-05      0.14      90     154 ..     664     727 ..     646     740 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.6e-05
   TBK1_CCD1  90 nlepsEldeiselhkkllrlssslerieeslqeiknklipeellsdewvkdegsqsedRnveklk 154
                 nle++  +++++  +++++ls ++++++++++ +k k++p+ell d + + ++     R+v  l 
  EFC39517.1 664 NLEAPKTSKVYNTTTEIHELSIAFDKMKTTVRSFK-KFVPNELLRDMLKNGNEITLGGRLVGNLT 727
                 677888999************************96.7*********9998888777777766655 PP

>> TPR_9  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1         5   1.5e+04      13      21 ..     798     806 ..     797     809 .. 0.84
   2 ?   10.9   0.3   0.00013      0.38      30      71 ..     940     981 ..     937     983 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 5
       TPR_9  13 ralavverl 21 
                 +al++++r+
  EFC39517.1 798 AALRCQQRM 806
                 799**9998 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00013
       TPR_9  30 eerrdRGlllaqlGclsaAladLeaylalapdapdaeairaq 71 
                 + +++R+l  + +G++++Al  +e +l + p++   +++r++
  EFC39517.1 940 RQIYERALEMYASGDFAQALLFFEECLKIRPEDGPSRTLRER 981
                 789************************************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1002 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       889  (0.0495845); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.83u 0.31s 00:00:01.13 Elapsed: 00:00:00.47
# Mc/sec: 6342.92
//
Query:       EFC39518.1  [L=714]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-05   24.7   0.8     0.0002   21.6   0.1    2.7  2  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.1   1.1e-08    0.0002       2     117 ..      75     286 ..      74     287 .. 0.92
   2 ?   -0.2   0.1     0.063   1.1e+03      84     113 ..     683     712 ..     634     713 .. 0.74

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 1.1e-08
                 HHHHHTSHHHHHHHHHHHHH.TTCTHHHHHHHHHHHHHTS........................................................... CS
         RGS   2 leslledqpgrslFreFles.efseenlsFwlaveefkka........................................................... 40 
                 +++++e ++ r++F ++l +   ++e ++F+ + ee+k+a                                                           
  EFC39518.1  75 FTEVMEVEAARNHFYDYLTNiALCNETVHFLRDFEEYKNAyflrfgnrllpnssfttssssttstprnstgtslfgrrktggntpqtldtksvrslnfv 173
                 78999*************9835699************************************************************************** PP

                 ..................SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS...................STTTTTTHHHHHHHHHHHH CS
         RGS  41 ..................keqeelkkkakeIyneylapsspkelnidkklreelekrleke...................qpsrklfeeaqeevfelle 102
                                   +  +   + a +I+++y+  + +    i+kk++++ e+  +++                      ++lf  +  +v++ ++
  EFC39518.1 174 ndifsgvvasssvaepyvNAIKICYALASVIMEKYIIGGLNLPNIINKKVKNNWETL-QNVyeanqwpeeayhfitmvelLSPENLFSTVYLAVLTDMK 271
                 *****************9999999999*********777776667777777665544.3336889*************998889*************** PP

                 HHHHHHHHTSHHHHH CS
         RGS 103 kdsypkFlkselylr 117
                  d++p++ +s++ ++
  EFC39518.1 272 LDQFPRYSRSDFLKN 286
                 ***********9876 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.063
                 STTTTTTHHHHHHHHHHHHHHHHHHHHTSH CS
         RGS  84 qpsrklfeeaqeevfellekdsypkFlkse 113
                 + + +lf+ + e+  ++ +++ y++Fl+s 
  EFC39518.1 683 KDDFHLFKTLRENMKTYPNRSWYSEFLNSS 712
                 456677777777778887888888888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (714 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       805  (0.0448993); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.51
# Mc/sec: 4207.30
//
Query:       EFC39519.1  [L=196]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (196 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       633  (0.0353059); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1125.34
//
Query:       EFC39520.1  [L=807]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.5e-19   67.4   0.6    3.2e-17   62.5   0.1    2.6  2  BACK      BTB And C-terminal Kelch
    2.6e-11   43.7   1.5    1.4e-10   41.3   1.5    2.3  1  BTB       BTB/POZ domain
    1.2e-06   28.6   0.3    2.8e-06   27.4   0.3    1.6  1  SPRY      SPRY domain


Domain annotation for each model (and alignments):
>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.027   1.6e+02       5      31 ..     397     423 ..     395     427 .. 0.92
   2 !   62.5   0.1   5.3e-21   3.2e-17      12      99 ..     435     523 ..     425     527 .. 0.94

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.027
        BACK   5 lefAeaysceeLaeaakefilknfeev 31 
                 le+A++y   +La+ ++ +++kn++e+
  EFC39520.1 397 LEIADKYMFVDLASICEAYLEKNLNEF 423
                 689********************9875 PP

  == domain 2  score: 62.5 bits;  conditional E-value: 5.3e-21
        BACK  12 sceeLaeaakefilknfeevlkseeFleL.skeqllellssdeLnvesEeevfeavlkWvkhdeeerkkhlpelLekvRlpllspeyLk 99 
                 + ++L+ +a +fi ++f  ++k+ + + + ++e +l+++s+d+Lnv++E+++++a+l Wv++d + rkk++p lL+++Rl+ lspe L+
  EFC39520.1 435 KYQSLKTKASQFIAQKFFIICKNGQLNLIgDVETVLNIISRDDLNVRTEDDILNAALLWVEYDFQVRKKYFPTLLNHIRLQYLSPECLH 523
                 6789**********************9985789*****************************************************997 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.3   1.5   2.4e-14   1.4e-10      20     110 ..     311     419 ..     294     420 .. 0.83

  Alignments for each domain:
  == domain 1  score: 41.3 bits;  conditional E-value: 2.4e-14
                 TEEEEE-HHHHHHH-HHHHHHHTST...................TTTTCCCEEEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHHT-HHH CS
         BTB  20 gkefkahkavLaarSpyFkalftsk...................eieessvseielddvepeafealLefiYtgeleitseenleelLaaadllqiprl 99 
                  ++++++ka+L+ +Sp+Fk+++ +k                    + +++ +e ++   + ++f ++++ +Yt e++   e + + lL++ad++ + +l
  EFC39520.1 311 STTLYVNKAILSLYSPFFKEMMFGKmktkcdfieimdhsvmecpDFHNNQDQENDIGYEDVRIFCIMIKTMYTLEVDCL-ECDSAPLLEIADKYMFVDL 408
                 6799*********************9999*99988888887776333333335666667777999*************8.******************* PP

                 HHHHHHHHHHH CS
         BTB 100 kkaceeflkqs 110
                 + +ce +l+++
  EFC39520.1 409 ASICEAYLEKN 419
                 ********987 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.4   0.3   4.8e-10   2.8e-06       4      98 ..     682     776 ..     679     802 .. 0.82

  Alignments for each domain:
  == domain 1  score: 27.4 bits;  conditional E-value: 4.8e-10
                 EEEEETCCTSSEEEEEEEETTSSSSSTSSSTSSTTEEEEETETTEEEEETESCEEEESSSS...TTSEEEEEEETTT.TEEEEEETTEEEEEEEESTTT CS
        SPRY   4 fevkiqsaeggsisvGlateqtdlsdksgegddrgswglcgdngtrtsaeqskaygkqpar...egdviGvalDlee.gelsFtkngknlgvaFrnvrg 98 
                 f  k++++ +g i +G+++ +++l+++      +  w++   ng+ +++  s +y + +++   +gd+  v +Dl + g+lsF kn + lg+aF+++ +
  EFC39520.1 682 FNLKVNKTAQGIINIGICKADVNLNGNLN---YENGWCYYLYNGHTCHNFHSLHYDD-NFGgggTGDTFKVQVDLRTnGTLSFVKNSQPLGIAFQEIVK 776
                 7788889999*************888865...5667**********9*********9.887666789*******97626***************98654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (807 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1382  (0.0770818); expected 358.6 (0.02)
Passed bias filter:                      479  (0.0267165); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.78u 0.32s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 4627.10
//
Query:       EFC39521.1  [L=463]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.3e-09   37.6   5.0     0.0091   15.7   0.3    4.4  3  DUF4116    Domain of unknown function (DUF4116)
     0.0079   16.5   0.3       0.24   11.8   0.0    2.8  3  RNaseH_C   T4 RNase H, C terminal
  ------ inclusion threshold ------
       0.12   12.0   1.6       0.56    9.8   0.1    2.3  2  Tenui_NCP  Tenuivirus major non-capsid protein


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0   0.00038       2.3       8      41 ..     233     269 ..     226     282 .. 0.79
   2 !   15.7   0.3   1.5e-06    0.0091       6      43 ..     289     326 ..     284     327 .. 0.82
   3 !   12.9   0.2   1.2e-05     0.071       1      31 [.     405     436 ..     400     450 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00038
     DUF4116   8 avkkngsalkylseeLknDkei...vlkAvkqngtal 41 
                  +k + + + yls eL++D ei   v++  + +++++
  EFC39521.1 233 FLKVHANFYPYLSVELRRDPEIlgaVKQLFETDPDSF 269
                 5677788999***********9888888888888654 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 1.5e-06
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngt.alsy 43 
                  +++ +n+s+l +l ++L++Dke+ +k +k +++ +++y
  EFC39521.1 289 FNLFNINSSHL-FLHHSLRKDKEFTIKLMKHYPYlVYPY 326
                 56778899999.*********************636666 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 1.2e-05
     DUF4116   1 DrEivleavkkngsalky.lseeLknDkeivl 31 
                 Dr+++le +++ + ++   +s+eL+n++e+++
  EFC39521.1 405 DRDVILEEISRRNVIFLSiASPELRNNREFIK 436
                 77888877776655555538**********97 PP

>> RNaseH_C  T4 RNase H, C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       1.4   8.1e+03      52      71 ..      79      98 ..      61     110 .. 0.73
   2 !   11.8   0.0     4e-05      0.24       5      43 ..     212     255 ..     209     270 .. 0.77
   3 ?    1.1   0.2     0.077   4.6e+02      63      91 ..     390     418 ..     370     435 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.4
                HH-GGGHHHHS-HHHHHHHH CS
    RNaseH_C 52 asdreelkkllteeeyaryk 71
                ++ + +lk+ lt+    ry+
  EFC39521.1 79 TNMQFHLKVWLTNCASGRYH 98
                56667788888888888886 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 4e-05
                 HHHHHHHHH....EBGGGTBE-TTS-TTHH.HH--TT------- CS
    RNaseH_C   5 idimtkilk....Gdkkdnvaslkvrsdfy.ftrveGerapsvk 43 
                 id m k +k    Gdkkd v  lkv+++fy +  ve +r p + 
  EFC39521.1 212 IDNMKKYVKimqeGDKKDLVEFLKVHANFYpYLSVELRRDPEIL 255
                 5667666554456****************977899999999874 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.077
                 -HHHHHHHHHHHHHH-GGGS-HHHHHHHH CS
    RNaseH_C  63 teeeyarykenlklldfdyipeniadsiv 91 
                  e+ +  yk n  l d d i e+i+   v
  EFC39521.1 390 NEHFHRNYKTNEYLEDRDVILEEISRRNV 418
                 3444456*****************97544 PP

>> Tenui_NCP  Tenuivirus major non-capsid protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   9.4e-05      0.56      54     117 ..      30      91 ..      15      99 .. 0.82
   2 ?    0.7   0.1     0.057   3.4e+02      56      81 ..     298     324 ..     276     337 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 9.4e-05
   Tenui_NCP  54 cvyiayhhpletdtlfikvhkhipefchsflshllggedddnalidiglffnmlqpslggwitk 117
                   + a +h  e + l+ k hk+  e++h + s  l  e+  n + + g f nm q  l  w+t+
  EFC39521.1  30 TTFDAIYHTEEKNDLIDKWHKYCQELAHDYDSPALSNEQLANLINQFG-FTNM-QFHLKVWLTN 91 
                 566788899999*************************99988666666.5565.8889999885 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.057
   Tenui_NCP  56 yiayhhpletdtlf.ikvhkhipefch 81 
                 ++  hh l  d  f ik+ kh p +++
  EFC39521.1 298 HLFLHHSLRKDKEFtIKLMKHYPYLVY 324
                 56689***99987659*****998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (463 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       628  (0.0350271); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2819.84
//
Query:       EFC39522.1  [L=1208]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.5e-52  176.4   0.5    4.5e-51  173.6   0.5    2.0  1  Pkinase_Tyr     Protein tyrosine kinase
    1.8e-49  168.5   0.1    3.3e-49  167.6   0.1    1.4  1  Pkinase         Protein kinase domain
     0.0093   15.9   0.1      0.015   15.2   0.1    1.2  1  APH             Phosphotransferase enzyme family
  ------ inclusion threshold ------
        0.1   11.4   0.2       0.16   10.7   0.2    1.2  1  Pkinase_fungal  Fungal protein kinase
       0.22   11.4  28.4       0.11   12.3  14.8    5.0  3  Beta_helix      Right handed beta helix region
        6.5    7.0   9.6         17    5.6   0.2    5.1  5  Pentapeptide_3  Pentapeptide repeats (9 copies)


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  173.6   0.5   1.5e-54   4.5e-51       1     259 []     913    1201 ..     913    1201 .. 0.86

  Alignments for each domain:
  == domain 1  score: 173.6 bits;  conditional E-value: 1.5e-54
                   EEEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHH..HHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHH CS
  Pkinase_Tyr    1 lelgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateee..keelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrk 94  
                   ++++k++GeG  ++V+ g+++      +++Va+K+lk + +e +  +ee+ +ea+++++l+hpn++ ++gvc+ e++ +ivtey+++G L+ f+ +
   EFC39522.1  913 ITIEKRIGEGGSANVFLGSWS------NINVAIKSLKYDFSEGSinNEEFEKEAAVLSRLRHPNVLIFYGVCMTEKSKYIVTEYMENGALDRFISN 1002
                   57899****************......9********998777654499************************************************ PP

                   T...CTTTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.... CS
  Pkinase_Tyr   95 k...ekekltlkdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.... 181 
                   +   + ++ +++++l++ l++++Gm yL+s k  ++Hrdl   NvLl++++++k+sDfGL + + ++  +++ +++   + +++pE++ + +    
   EFC39522.1 1003 SkysNFTNQHFQNVLKILLHISNGMIYLHSLKpaIIHRDLKPGNVLLNDKNQAKVSDFGLVKLV-SNTVQTNMTKQIGTILYCSPETFVSDTqien 1097
                   933333444567799**************987779****************************9.66666778888999*******9977665665 PP

                   .EEHHHHHHHHHHHHHHHHTTSSGT.......................TTTSHHHHHHHHHHTTEES-BBT...TSBHHHHHHHHHHT-SSGGGS- CS
  Pkinase_Tyr  182 .ftsksDvWsfGvllwEiftlgesp.......................ypglkneevleklkegkrlekpe...kcpeelyelmkkcweedpeeRp 250 
                      sk Dv+sf++++wE+f   ++p                       +   +  e+ + ++++++l +++   +c + + +lm++cw+++p+eRp
   EFC39522.1 1098 kEASKIDVYSFAIIMWEMFFR-ATPfqhvkntfkvpplvingqrpllpFDVSNRDEINQWITTNTQLFTNDdtiECVQLFINLMTECWKHNPSERP 1192
                   577888*************95.56658899999999999999999986555567778888999999887762225777888*************** PP

                   -HHHHHHHH CS
  Pkinase_Tyr  251 tfselvekl 259 
                   +f+++ e l
   EFC39522.1 1193 SFNKIYELL 1201
                   ****99865 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  167.6   0.1   1.1e-52   3.3e-49       3     259 ..     915    1198 ..     913    1201 .. 0.83

  Alignments for each domain:
  == domain 1  score: 167.6 bits;  conditional E-value: 1.1e-52
                  EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH..HHSS-- CS
     Pkinase    3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle..rkgsls 96  
                   ++++GeG++++V+ +   +++  vA+K +k +  + + + +++ +E ++l +l+hpn++ +y+v+ ++++ y+v+ey+e+g l+++++  + ++++
  EFC39522.1  915 IEKRIGEGGSANVFLGS--WSNINVAIKSLKYDFSEGSINnEEFEKEAAVLSRLRHPNVLIFYGVCMTEKSKYIVTEYMENGALDRFISnsKYSNFT 1009
                  6799************9..9***********99777666559***********************************************65444588 PP

                  HHHHH...HHHHHHHHHHHHHHHTT..EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH.....TTSCBSHHHHHH CS
     Pkinase   97 eeeak...kiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl.....keneyskkvDvW 181 
                  +++ +   ki+ +i +g+ ylHs +  iiHrDlKp N+L+++k++ K++DFGl+k ++++ +  +t+++gt  Y++PE        en+  +k+Dv+
  EFC39522.1 1010 NQHFQnvlKILLHISNGMIYLHSLKpaIIHRDLKPGNVLLNDKNQAKVSDFGLVKLVSNTVQtnMTKQIGTILYCSPETFvsdtqIENKEASKIDVY 1106
                  886663336788999*******98888********************************99999**************99877644477799***** PP

                  HHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT....SHH...HHHTTS.............-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase  182 slGvilyelltgkppfsgekgkekvekeldqlekilkilg....etkeklpeasei.............seeakdllkkllkkdpkkRltaeell 259 
                  s ++i++e++++ +pf++ k++ kv   + + ++ l  ++    +   +++++ +               + +++l+++++k +p++R++++++ 
  EFC39522.1 1107 SFAIIMWEMFFRATPFQHVKNTFKVPPLVINGQRPLLPFDvsnrD---EINQWITTntqlftnddtiecVQLFINLMTECWKHNPSERPSFNKIY 1198
                  *****************8888776655544433322222232242...222222225557888888899999******************99886 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.1     5e-06     0.015     163     196 ..    1032    1063 ..    1008    1066 .. 0.76

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 5e-06
                  SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH  163 elptvllHgDlhpgNllvdpddgrvtGviDfeda 196 
                  +l++ ++H+Dl+pgN+l+++ ++    v Df+++
  EFC39522.1 1032 SLKPAIIHRDLKPGNVLLNDKNQAK--VSDFGLV 1063
                  6899***************554444..7777776 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.2   5.3e-05      0.16     249     379 ..     870    1082 ..     820    1091 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 5.3e-05
  Pkinase_fungal  249 sskaevklkksesskkvekrsvdssvstskrsr............................................................ 281 
                      ss +++k ++ ++ ++ +++ v+s+++tsk ++                                                            
      EFC39522.1  870 SSGGSTKYRSLTNDTELSQSLVKSNSKTSKYQKddsfiipieeitiekrigeggsanvflgswsninvaikslkydfsegsinneefekeaav 962 
                      344444444444444444444444444444444566677777777777777777777777777777777777777777777777777777777 PP

  Pkinase_fungal  282 ............................lenrvhrrlvispvGkpi..ekaespkellealrDaIkghrsLflkagiLHrDiSenNilitdsk 344 
                                                  +en  + r + +++      +++++++++l  + +    + sL     i+HrD   +N+l++d+ 
      EFC39522.1  963 lsrlrhpnvlifygvcmtekskyivteyMENGALDRFISNSKYSNFtnQHFQNVLKILLHISNGMIYLHSLK--PAIIHRDLKPGNVLLNDK- 1052
                      777777777777777777777777777766777777776665555411467777777777777777777776..89**************55. PP

  Pkinase_fungal  345 kegerkglLiDLDlakelsddssesgarertGTle 379 
                          ++  ++D+ l k +s+ + + +  +++GT+ 
      EFC39522.1 1053 ----NQAKVSDFGLVKLVSN-TVQTNMTKQIGTIL 1082
                      ....5556777777777775.44444567777765 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.9   8.2         6   1.8e+04     122     132 ..     332     344 ..     226     422 .. 0.50
   2 ?   12.3  14.8   3.7e-05      0.11      10     137 ..     476     639 ..     335     679 .. 0.69
   3 ?   -1.7   0.1      0.76   2.3e+03      13      69 ..    1065    1100 ..    1045    1111 .. 0.52

  Alignments for each domain:
  == domain 1  score: -5.9 bits;  conditional E-value: 6
                 -TT..---EEES- CS
  Beta_helix 122 dss..snvtvtnN 132
                  +   + vt+tn+
  EFC39522.1 332 HTFacNYVTFTNC 344
                 2222222222222 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 3.7e-05
                 E..EEESEEEES-SS-SEEE-SSS-.EEES-EEES..-SS-SEEE-TT...-S-EEES-EEE---......................SEEE-TT.--S- CS
  Beta_helix  10 n.vtiknntisnsggyGiylrgssnvvienneian..nsgsGiyilgs...snntisnntisdnn......................gggialf.gasn 79 
                 + v ++n++++ns+++++++++ ++  i+ +e++n   ++sG +++     +n  i+++++ +n                       +++++    + +
  EFC39522.1 476 SqVLFSNSKFYNSYDSAVTIQSVQRLFIDYCEFYNnlATFSGAAVRVKylaANLFIRGSKFINNRvtcnlypmsrygafcgggaisiESAVNDAkFTPP 574
                 135677777777777777777777777777777776656666666655667666666666666666666666655544444333333222221112222 PP

                 -EEES-EEES-...SS-SEE-T.T-S--EEES-EEESTT....--SEE---TT....---EEES-EEES- CS
  Beta_helix  80 nlienneitdn...ggsGiyln.yssnntienNiidnna....gsGividdss....snvtvtnNtitnn 137
                   +++ +++ n   +g  iy+  +s+++ ++++++ nn+    g ++++++      s     ++t+++n
  EFC39522.1 575 YEFNGVNFIGNyadRGGAIYFPtGSYQLNFQYSQFVNNTarlsGGAMFFNQATlptlS-----GCTLNGN 639
                 2233333333344422255555446666666666666666665444444444443333.....3333333 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.76
                  EESEEEES-..SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---S CS
  Beta_helix   13 iknntisns..ggyGiylrgssnvvienneiannsgsGiyilgssnntisnntisdnng 69  
                  +  nt++ +  +                       + G  +++s+++ +s+ +i++  +
  EFC39522.1 1065 LVSNTVQTNmtK-----------------------QIGTILYCSPETFVSDTQIENKEA 1100
                  333333333333.......................444444444555555555554432 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   0.2    0.0058        17      17      33 ..     390     406 ..     386     411 .. 0.74
   2 ?    2.2   0.2     0.069   2.1e+02       1      36 [.     480     518 ..     476     521 .. 0.71
   3 ?   -1.2   0.0      0.79   2.4e+03      22      36 ..     576     592 ..     566     596 .. 0.59
   4 ?   -1.7   0.0       1.2   3.5e+03      22      35 ..     603     618 ..     597     618 .. 0.78
   5 ?   -0.1   0.2      0.37   1.1e+03      15      29 ..     614     632 ..     603     641 .. 0.63

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0058
  Pentapeptide_3  17 FsgaasFsnadFgsadF 33 
                     Fs+ +sF+na F++++ 
      EFC39522.1 390 FSSVTSFQNAIFENITM 406
                     78888888888876554 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.069
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaa...sFsnadF..gsadFsga 36 
                     Fs++ F+++   + a+ ++++   + + + F  + a+Fsga
      EFC39522.1 480 FSNSKFYNS--YDSAVTIQSVqrlFIDYCEFynNLATFSGA 518
                     666777776..666666666666668888888558888887 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.79
  Pentapeptide_3  22 sFsnadF..gsadFsga 36 
                      F++ +F  + ad  ga
      EFC39522.1 576 EFNGVNFigNYADRGGA 592
                     46666666336666665 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 1.2
  Pentapeptide_3  22 sFsnadF..gsadFsg 35 
                     +F+ ++F  ++a++sg
      EFC39522.1 603 NFQYSQFvnNTARLSG 618
                     8999999955999876 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 0.37
  Pentapeptide_3  15 atFsgaa.sFsnadF...g 29 
                     a+ sg+a +F++a++   +
      EFC39522.1 614 ARLSGGAmFFNQATLptlS 632
                     5566666666666664333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1208 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       841  (0.0469072); expected 358.6 (0.02)
Passed bias filter:                      448  (0.0249875); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.52
# Mc/sec: 6999.93
//
Query:       EFC39523.1  [L=492]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.5e-07   30.1   1.2    9.7e-07   29.1   1.2    1.6  1  RGS            Regulator of G protein signaling domain
     0.0094   15.8   0.1      0.019   14.9   0.1    1.4  1  Phage_NinH     Phage NinH protein
  ------ inclusion threshold ------
       0.45   10.4   1.9       0.59   10.0   0.6    1.9  2  Deltameth_res  Deltamethrin resistance


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.1   1.2   1.6e-10   9.7e-07       3     115 ..      14     182 ..      12     185 .. 0.82

  Alignments for each domain:
  == domain 1  score: 29.1 bits;  conditional E-value: 1.6e-10
                 HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS......................................SHHHHHHHHHHHHHHHHTSTTST CS
         RGS   3 eslledqpgrslFreFlesefseenlsFwlaveefkka......................................keqeelkkkakeIyneylapssp 63 
                 e+ ++ ++ r++F++Fle+ +++e + F  +v e+ ++                                      ++ ++l++k+++I++++l+ + +
  EFC39523.1  14 EEAIKCSQFRRVFQQFLEKHHNQESILFINKVIEYTEEykkiagisadnfslmmlketqqletdvarrvsvqkivrRNLDSLQEKMNAIVKTFLQVGGE 112
                 666777889***********************9999999999**********************************999******************** PP

                 TSSTS-HHHHHHHHHHHCSS..................STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHH CS
         RGS  64 kelnidkklreelekrleke..................qpsrklfeeaqeevfellekdsypkFlksely 115
                 +elni  + r++l+   e++                      kl+  +   ++  l    ++kF +s+ +
  EFC39523.1 113 QELNIGPHQRSSLKLWKETSeklnnetfsfdsqeildeLHPGKLLGSIILVILVDLGMGHFTKFSRSDQF 182
                 *****99988877766555554555566666666666544456666666666666666666666666666 PP

>> Phage_NinH  Phage NinH protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1   3.1e-06     0.019      11      54 ..      67     109 ..      65     113 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 3.1e-06
  Phage_NinH  11 lLvetyGnqtEvARrlkcsRatvRkYvrDkeakqHAivngvLmv 54 
                 +L et+   t+vARr++ +   vR+ ++  + k+ Aiv   L v
  EFC39523.1  67 MLKETQQLETDVARRVSVQ-KIVRRNLDSLQEKMNAIVKTFLQV 109
                 89999999********887.58****************988765 PP

>> Deltameth_res  Deltamethrin resistance
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0         1     6e+03       9      18 ..     238     247 ..     238     249 .. 0.89
   2 ?   10.0   0.6   9.9e-05      0.59       6      23 ..     470     487 ..     468     490 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1
  Deltameth_res   9 dwkeqysakq 18 
                    dwk  y++++
     EFC39523.1 238 DWKVVYEKNN 247
                    8******998 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 9.9e-05
  Deltameth_res   6 PeGdwkeqysakqrkYNa 23 
                    P  +w+ ++++ q+kYN 
     EFC39523.1 470 PNRSWFMEWKESQSKYNS 487
                    8889*************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (492 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       850  (0.0474092); expected 358.6 (0.02)
Passed bias filter:                      529  (0.0295053); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2825.51
//
Query:       EFC39524.1  [L=272]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-22   79.7  25.9    7.9e-08   32.5   4.0    6.7  8  LRR_4     Leucine Rich repeats (2 copies)
    1.7e-21   74.3  28.1     0.0029   17.5   0.0    8.1  8  LRR_6     Leucine Rich repeat
    2.2e-21   75.3  23.5    7.9e-07   28.7   0.1    5.9  8  LRR_8     Leucine rich repeat
    9.7e-10   37.6  21.9        2.5    9.0   0.0    8.5  9  LRR_1     Leucine Rich Repeat
    2.7e-05   24.1   3.9     0.0029   17.6   0.4    2.3  2  LRR_5     BspA type Leucine rich repeat region (6 copies)
    0.00077   19.0   8.1        0.4   10.2   3.3    3.5  3  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
      0.088   13.4   0.0       0.22   12.2   0.0    1.6  1  MgtE_N    MgtE intracellular N domain
      0.098   12.8   0.0       0.15   12.2   0.0    1.2  1  MukF_C    MukF C-terminal domain


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.1      0.64   1.4e+03      23      32 ..       2      12 ..       1      28 [. 0.75
   2 !    5.9   0.0     0.008        18      13      31 ..      38      56 ..      27      62 .. 0.67
   3 !   14.1   3.1   2.1e-05     0.047       2      35 ..      49      85 ..      48      88 .. 0.85
   4 !   32.5   4.0   3.5e-11   7.9e-08       2      39 ..      98     135 ..      97     143 .. 0.88
   5 !    6.3   0.0    0.0062        14      18      36 ..     139     157 ..     135     165 .. 0.76
   6 !    7.1   0.0    0.0035       7.9       2      29 ..     145     175 ..     144     183 .. 0.76
   7 !   15.1   0.0     1e-05     0.023       2      38 ..     170     206 ..     169     210 .. 0.77
   8 !   20.7   0.1   1.8e-07    0.0004       1      35 [.     216     252 ..     216     269 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.64
                TT--EEE-..- CS
       LRR_4 23 pnLkeLdL.sg 32
                 nL eLdL ++
  EFC39524.1  2 NNLVELDLhWR 12
                68889998554 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.008
                --E-S-HHH-TT--EEE-. CS
       LRR_4 13 ltdiplleklpnLkeLdLs 31
                l  ++ +++++nL+eL++s
  EFC39524.1 38 LGYFGDIGGMDNLTELNVS 56
                444455667********93 PP

  == domain 3  score: 14.1 bits;  conditional E-value: 2.1e-05
                S--EEE--.SS---E-S-...HHH-TT--EEE-.-S-- CS
       LRR_4  2 nLevLdLs.nNqltdipl...leklpnLkeLdLsgNnl 35
                nL++L+ s n  ++  +    + kl nL +L++s+Nnl
  EFC39524.1 49 NLTELNVSwN-GIKGCDDtqpIVKLQNLVKLNISRNNL 85
                9*******77.***9999775559************65 PP

  == domain 4  score: 32.5 bits;  conditional E-value: 3.5e-11
                 S--EEE--SS---E-S-.HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpnLkeLdLsgNnlitdl 39 
                 nL+ Ld+snN l d++  ++k++nL++Ld+s+N +++++
  EFC39524.1  98 NLTDLDISNNSLDDLSYlFSKMKNLTVLDVSEN-RLSPF 135
                 9****************8778*********999.76666 PP

  == domain 5  score: 6.3 bits;  conditional E-value: 0.0062
                 -HHH-TT--EEE-.-S--- CS
       LRR_4  18 lleklpnLkeLdLsgNnli 36 
                 +++ l +L+ Ld+s+N  i
  EFC39524.1 139 SISELVQLTDLDISDNREI 157
                 4444999******999655 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.0035
                 S--EEE--SS-.--E-S-HH..H-TT--EEE CS
       LRR_4   2 nLevLdLsnNq.ltdiplle..klpnLkeLd 29 
                 +L+ Ld+s+N+ + + + ++  ++++L+ L 
  EFC39524.1 145 QLTDLDISDNReIGEEGAISisGMKQLRILK 175
                 6999****99559988884443699999986 PP

  == domain 7  score: 15.1 bits;  conditional E-value: 1e-05
                 S--EEE--SS---E-S-.HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl.leklpnLkeLdLsgNnlitd 38 
                 +L++L +++  l +    +++++nL++Ld+sgN +i+d
  EFC39524.1 170 QLRILKFRDIELGEAAKiFSQMDNLTQLDISGN-FIDD 206
                 678888888667754446889***********9.8865 PP

  == domain 8  score: 20.7 bits;  conditional E-value: 1.8e-07
                 SS--EEE--.SS---E-S-...HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLs.nNqltdipl...leklpnLkeLdLsgNnl 35 
                 +nL++Ld s n  +td +    +e++pnL+++ +++N +
  EFC39524.1 216 QNLTYLDASwN-DITDAGVkiiCENMPNLTSIFINEN-P 252
                 79*******76.****999988779*********999.3 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       1.6   3.7e+03       3      10 ..       2       9 ..       1      11 [. 0.83
   2 !   11.2   0.1   0.00014      0.31       4      16 ..      49      61 ..      48      62 .. 0.91
   3 !   17.2   0.6   1.7e-06    0.0037       3      24 .]      73      94 ..      71      94 .. 0.92
   4 !    5.5   2.1    0.0093        21       4      17 ..      98     111 ..      95     112 .. 0.91
   5 !    7.2   0.0    0.0026       5.9       3      17 ..     120     134 ..     118     141 .. 0.80
   6 !   15.0   0.0   8.3e-06     0.019       5      24 .]     146     166 ..     144     166 .. 0.94
   7 !   14.6   0.2   1.2e-05     0.026       4      24 .]     193     213 ..     192     213 .. 0.93
   8 !   17.5   0.0   1.3e-06    0.0029       3      21 ..     216     234 ..     214     237 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1.6
       LRR_6  3 thLteLdL 10
                ++L eLdL
  EFC39524.1  2 NNLVELDL 9 
                6899***9 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00014
       LRR_6  4 hLteLdLsgNdIg 16
                +LteL++s+N+I 
  EFC39524.1 49 NLTELNVSWNGIK 61
                79*********96 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 1.7e-06
       LRR_6  3 thLteLdLsgNdIgDeGaeaLa 24
                ++L +L++s N+++++Ga+ L+
  EFC39524.1 73 QNLVKLNISRNNLSNKGAKLLS 94
                89*****************986 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.0093
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +Lt Ld+s N ++D
  EFC39524.1  98 NLTDLDISNNSLDD 111
                 7*********9998 PP

  == domain 5  score: 7.2 bits;  conditional E-value: 0.0026
       LRR_6   3 thLteLdLsgNdIgD 17 
                  +Lt Ld+s N ++ 
  EFC39524.1 120 KNLTVLDVSENRLSP 134
                 58*********9986 PP

  == domain 6  score: 15.0 bits;  conditional E-value: 8.3e-06
       LRR_6   5 LteLdLsgNd.IgDeGaeaLa 24 
                 Lt Ld+s+N  Ig eGa++++
  EFC39524.1 146 LTDLDISDNReIGEEGAISIS 166
                 9*****************996 PP

  == domain 7  score: 14.6 bits;  conditional E-value: 1.2e-05
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt Ld+sgN I+D+G++ ++
  EFC39524.1 193 NLTQLDISGNFIDDKGIKLIS 213
                 69***************9885 PP

  == domain 8  score: 17.5 bits;  conditional E-value: 1.3e-06
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 ++Lt+Ld s+NdI+D+G++
  EFC39524.1 216 QNLTYLDASWNDITDAGVK 234
                 79***************98 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.8   3.9e+03      49      56 ..       2       9 ..       1      15 [. 0.59
   2 ?   -3.6   0.0       4.3   9.6e+03      47      58 ..      25      36 ..      23      36 .. 0.63
   3 ?    4.3   0.0     0.015        34      45      61 .]      44      60 ..      42      60 .. 0.83
   4 !   26.8   8.1   1.5e-09   3.3e-06       2      61 .]      49     109 ..      48     109 .. 0.94
   5 !   28.7   0.1   3.5e-10   7.9e-07      20      60 ..     115     155 ..     113     155 .. 0.97
   6 ?   -1.4   0.0      0.91     2e+03      21      31 ..     165     175 ..     161     178 .. 0.55
   7 !   24.1   0.0   9.7e-09   2.2e-05      19      61 .]     186     228 ..     184     228 .. 0.96
   8 ?    2.2   0.1     0.067   1.5e+02      23      36 ..     239     252 ..     235     271 .. 0.72

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.8
                -S-.EEE- CS
       LRR_8 49 psLrsLdL 56
                ++L +LdL
  EFC39524.1  2 NNLVELDL 9 
                44455554 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 4.3
                T--S-.EEE--S CS
       LRR_8 47 gLpsLrsLdLsg 58
                 L+++r+L +++
  EFC39524.1 25 KLKQVRKLSVTH 36
                677777777655 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.015
                GTT--S-.EEE--SS-- CS
       LRR_8 45 fsgLpsLrsLdLsgNrL 61
                + g+ +L++L++s+N +
  EFC39524.1 44 IGGMDNLTELNVSWNGI 60
                56899999999999976 PP

  == domain 4  score: 26.8 bits;  conditional E-value: 1.5e-09
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+L++s N +++ dd++    l+nL  L++s+N+l+   ++ +s L +L+ Ld+s+N L
  EFC39524.1  49 NLTELNVSWNGIKGCDDTQPIVkLQNLVKLNISRNNLSNKGAKLLSKLVNLTDLDISNNSL 109
                 8*************999886555************************************87 PP

  == domain 5  score: 28.7 bits;  conditional E-value: 3.5e-10
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                  F++++nL+vLd s+N+l+ ++ +++s L +L+ Ld+s+Nr
  EFC39524.1 115 LFSKMKNLTVLDVSENRLSPFDVESISELVQLTDLDISDNR 155
                 599*************************************6 PP

  == domain 6  score: -1.4 bits;  conditional E-value: 0.91
                 STT-TT--EEE CS
       LRR_8  21 FkglsnLkvLd 31 
                  +g+++L++L+
  EFC39524.1 165 ISGMKQLRILK 175
                 34555555554 PP

  == domain 7  score: 24.1 bits;  conditional E-value: 9.7e-09
                 TSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  19 eaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + F+++ nL+ Ld+s N ++    + +sg+ +L++Ld s+N++
  EFC39524.1 186 KIFSQMDNLTQLDISGNFIDDKGIKLISGMQNLTYLDASWNDI 228
                 67***************************************97 PP

  == domain 8  score: 2.2 bits;  conditional E-value: 0.067
                 T-TT--EEE--SS- CS
       LRR_8  23 glsnLkvLdLsnNl 36 
                 +++nL+++ +++N 
  EFC39524.1 239 NMPNLTSIFINENP 252
                 67888888888774 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.1       1.6   3.6e+03       1       9 [.       3      11 ..       3      19 .. 0.82
   2 !    6.7   0.0    0.0061        14       1      12 [.      49      60 ..      49      70 .. 0.85
   3 !    7.5   1.1    0.0033       7.4       1      23 []      74      96 ..      74      96 .. 0.88
   4 !    8.6   0.3    0.0015       3.3       1      15 [.      98     112 ..      98     119 .. 0.80
   5 ?    5.6   0.0     0.015        33       1      21 [.     121     141 ..     121     143 .. 0.80
   6 ?    2.2   0.0      0.19   4.3e+02       2      13 ..     146     157 ..     145     167 .. 0.81
   7 !    9.0   0.0    0.0011       2.5       1      20 [.     193     212 ..     193     215 .. 0.83
   8 ?    5.6   0.0     0.015        33       1      14 [.     217     230 ..     217     239 .. 0.82
   9 ?   -0.8   0.1       1.8     4e+03       1      20 [.     242     261 ..     242     266 .. 0.70

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 1.6
       LRR_1  1 nLrhLdLsn 9 
                nL +LdL +
  EFC39524.1  3 NLVELDLHW 11
                899***976 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0061
       LRR_1  1 nLrhLdLsnnpl 12
                nL++L++s+n +
  EFC39524.1 49 NLTELNVSWNGI 60
                8*********87 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0033
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                nL +L++s+n+l+++++  +++L
  EFC39524.1 74 NLVKLNISRNNLSNKGAKLLSKL 96
                899*********99998888776 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.0015
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL+ Ld+snn+l++l
  EFC39524.1  98 NLTDLDISNNSLDDL 112
                 899*********554 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++Ld+s n+l+ +  +s++
  EFC39524.1 121 NLTVLDVSENRLSPFDVESIS 141
                 8**********9766666665 PP

  == domain 6  score: 2.2 bits;  conditional E-value: 0.19
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ Ld+s+n+ +
  EFC39524.1 146 LTDLDISDNREI 157
                 889******864 PP

  == domain 7  score: 9.0 bits;  conditional E-value: 0.0011
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL+ Ld+s+n+++++++  +
  EFC39524.1 193 NLTQLDISGNFIDDKGIKLI 212
                 89**********88877665 PP

  == domain 8  score: 5.6 bits;  conditional E-value: 0.015
       LRR_1   1 nLrhLdLsnnpllg 14 
                 nL++Ld s+n +++
  EFC39524.1 217 NLTYLDASWNDITD 230
                 8*********9976 PP

  == domain 9  score: -0.8 bits;  conditional E-value: 1.8
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL+++ ++ np + ++ n +
  EFC39524.1 242 NLTSIFINENPVEEKGCNML 261
                 89999999999755555544 PP

>> LRR_5  BspA type Leucine rich repeat region (6 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.4   1.3e-06    0.0029      34     117 ..      73     158 ..      70     169 .. 0.88
   2 !    7.8   0.2    0.0013         3      51     112 ..     186     251 ..     166     271 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.3e-06
       LRR_5  34 tslksitlps.slteigsyaFsncssltsitipssltsigeyaFsncsslkeitlpsn.lttigssaFsnc.slesitipssvtkig 117
                 ++l +++++  +l++ g +  s+  +lt+++i+++     +y Fs++++l+ +++++n l+ ++ +++s+  +l+++ i+++ ++ig
  EFC39524.1  73 QNLVKLNISRnNLSNKGAKLLSKLVNLTDLDISNNSLDDLSYLFSKMKNLTVLDVSENrLSPFDVESISELvQLTDLDISDN-REIG 158
                 688899997637**********************999999***************9988***********88*******876.4554 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0013
       LRR_5  51 yaFsncssltsitips.sltsigeyaFsncsslkeitlpsn.lttigssaF.snc.slesitipss 112
                 ++Fs++++lt+++i+   ++  g +  s++++l+ ++ + n +t+ g +++ +n+ +l+si i+++
  EFC39524.1 186 KIFSQMDNLTQLDISGnFIDDKGIKLISGMQNLTYLDASWNdITDAGVKIIcENMpNLTSIFINEN 251
                 578888888888887525777778888888888888876443888887775366788888888765 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   3.3   0.00018       0.4      41     125 ..      47     132 ..      19     157 .. 0.79
   2 !    6.9   0.6    0.0018         4      86     162 ..     118     188 ..      99     196 .. 0.67
   3 !    4.9   0.1    0.0074        17      46     118 ..     196     270 ..     189     272 .] 0.68

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00018
       LRR_9  41 ldqfdtidlsdndirkldgf.Pl..lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 +d +  +++s n i+  d+  P   l+ l  l ++ n + + + +l   l nl+ l ++nn+l++l+ l  + ++k+l++l + +n +
  EFC39524.1  47 MDNLTELNVSWNGIKGCDDTqPIvkLQNLVKLNISRNNLSNKGAKLLSKLVNLTDLDISNNSLDDLSYL--FSKMKNLTVLDVSENRL 132
                 577777888999999887642432256777788889999999999999999999999999999999985..67888888888777765 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.0018
       LRR_9  86 vlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlldfrkvklkereeaeklf 162
                  + nl+ l +++n+l    d++ + +l +l+ l + +n  + ++      i  +kqlr+l fr + l e   a+k+f
  EFC39524.1 118 KMKNLTVLDVSENRLSP-FDVESISELVQLTDLDISDNREIGEE--GAISISGMKQLRILKFRDIELGE---AAKIF 188
                 34556666666666655.47788888888888888888766555..45678889999999999988776...55555 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.0074
       LRR_9  46 tidlsdndi..rkldgfPllkrlktlllnnnrivriaeg.leevlPnleelvltnnelqeladldPlaslkklell 118
                  +d+s n i  + +  +  ++ l  l  + n i+  + + + e +Pnl+++ +++n ++e +  + l s+kk ++l
  EFC39524.1 196 QLDISGNFIddKGIKLISGMQNLTYLDASWNDITDAGVKiICENMPNLTSIFINENPVEEKGC-NMLSSFKKWKNL 270
                 55555554421334555567777788888888988876625799************9998764.677777776655 PP

>> MgtE_N  MgtE intracellular N domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   9.7e-05      0.22      16      68 ..     170     222 ..     163     248 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 9.7e-05
                 HHHHHHHHHS-HHHHHHHHCTS-CCCCCHHHHCS-HHHHHHHHCCS-HHHHHH CS
      MgtE_N  16 eeraallrllpkeeaaevleeldedlqeeliealsdeelaelleeldsDdaad 68 
                 + r++ +r ++  eaa++++++d  +q ++  ++ d++  +l++ +++    d
  EFC39524.1 170 QLRILKFRDIELGEAAKIFSQMDNLTQLDISGNFIDDKGIKLISGMQNLTYLD 222
                 678888999*************************************9765555 PP

>> MukF_C  MukF C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   6.9e-05      0.15      25     151 ..     108     236 ..     100     241 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 6.9e-05
                 HGGGS-EEEEEE----EEE--XXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX. CS
      MukF_C  25 dyfdepwlltvadaerlldlrdeelalrdeevtGelP..eeleyeeleeieeqlaerieealavykekgkpldlaevlrdylakyPksqhfdvarllv. 120
                 + +d ++l+   ++  +ld+ +++l+  d e++ el   ++l+  + +ei e+ a +i+ + +    k + ++l+e  +  +++  +   +d++  ++ 
  EFC39524.1 108 SLDDLSYLFSKMKNLTVLDVSENRLSPFDVESISELVqlTDLDISDNREIGEEGAISISGMKQLRILKFRDIELGEAAK-IFSQMDNLTQLDISGNFId 205
                 5677788888888899999999999999*****999733589999999****9999999998888889999****9876.56778888899**987772 PP

                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
      MukF_C 121 dqavrlGvaeedlsglqpeWkaindaGakvq 151
                 d+ ++l    ++l+ l ++W+ i daG k+ 
  EFC39524.1 206 DKGIKLISGMQNLTYLDASWNDITDAGVKII 236
                 579************************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (272 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       407  (0.0227007); expected 358.6 (0.02)
Passed bias filter:                      282  (0.0157287); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.59u 0.34s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1562.31
//
Query:       EFC39525.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-08   35.1   0.1    2.4e-08   34.7   0.1    1.2  1  Metallophos  Calcineurin-like phosphoesterase


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.7   0.1   1.4e-12   2.4e-08       4     203 ..      41     272 ..      38     273 .. 0.64

  Alignments for each domain:
  == domain 1  score: 34.7 bits;  conditional E-value: 1.4e-12
                  EEEESBTBTTCCTHHHHHHHHHHHH............HHHTTESEEEEESTSSSSS..HHHHHHHHHHHHHHHHTSEEEEEC-TTSCHHHHHHHHHHH CS
  Metallophos   4 lvigDlHlalgggqlddllkllddl............lreekpdlvllaGDlvdrg..dlekellellaalvkypipvylllGNHegfeeellnkygy 87 
                   + +D+H       ++++++l++++            + e k  ++ l+GD+ d    ++e++++e+ a+++k    v+++ GNHe ++ ++ +  ++
   EFC39525.1  41 QLASDVH-----LEFPQVKALISNVaeedgkisretnIIEAKGEVLGLLGDIGDPFslEYEQFVMEQ-AEKFK---IVFIVTGNHE-YYRNIISE-TD 127
                  5689***.....9999999999777444444444444333566777788******977888888888.55555...39********.55555555.55 PP

                  HHHHHHHHEHHHCEEETSEEEEEETTE.EEEEEEESE.....CEEE..............THHHHHHHHHHHSCHHHHCC.........HHHHHH... CS
  Metallophos  88 lgifsepwrsdaevfnnlplaslgsgs.lkvlllhGg.....spel..............lvsldklgslnleleapepg.........dewlkd... 153
                  + i+   +++d+ vf n  ++++ + s  ++ ++ G      +  l                ++++ +                     +e l +   
   EFC39525.1 128 QRIMDICKKKDNLVFLNKSSFVYENESgKRIRFVGGTlwtnvP--LkerskveysmndyrRIKTNSEK-----------CvtisetiemHERLVEyir 212
                  6666666666677777777777666667677777777555330..14444442333323223333333...........1444555556666666677 PP

                  .HHHHTTCSEEEEEESSESSCSSSCSCCHHHHH..........HHHHHTTESEEEEESSSS CS
  Metallophos 154 .lekrekadwvivlgHsplyrgsgylfgdeale..........dllkkygvdlvisGHtHv 203
                     ++ + +++ vl+H+ +   +g + +de +            +++  ++  + +GHtH+
   EFC39525.1 213 kECEKHPEETIAVLTHHSPF-INGTVLEDEMFLasgmatnldhIIKQHSNISFWGFGHTHR 272
                  688999999***********.55555555555566666777744499999**********7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       810  (0.0451782); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.48
# Mc/sec: 2029.56
//
Query:       EFC39526.1  [L=944]
Description: rho GTPase activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.2e-24   84.5   0.1    6.2e-24   84.5   0.1    2.8  3  RhoGAP    RhoGAP domain


Domain annotation for each model (and alignments):
>> RhoGAP  RhoGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   84.5   0.1   3.5e-28   6.2e-24       1     148 [.     314     489 ..     314     493 .. 0.89
   2 ?   -3.1   1.6      0.35   6.3e+03      78     109 ..     652     684 ..     613     709 .. 0.60
   3 ?   -2.5   0.9      0.22   3.9e+03      77      98 ..     823     844 ..     790     872 .. 0.58

  Alignments for each domain:
  == domain 1  score: 84.5 bits;  conditional E-value: 3.5e-28
                 BHHHHHHHHHHHHHT.......TTSTTTTTS-S-HHHHHHHHHHHHHTGGGCT.......TTTTSCHHHHHHHHHHHHHHSSSTTTTGGHHHHHHHHHT CS
      RhoGAP   1 Piivekcvefiekrg.......ldtegiyRvsgskarvkelreafdkgkavds.......dleeedvhavaslLKrfLrelpepLltkelyeelieaak 85 
                 P++++ c +f+++++       +  egi+R+ gsk ++++  ++f++  a             ++d h va+l+KrfLre+++pLl++e y+e+i++ +
  EFC39526.1 314 PFVLRACFHFLKSNDpssqtprVANEGIFRQAGSKVKIEKFMKKFNTLLAFPTifpngihFPPNTDAHLVADLIKRFLREMQDPLLSYEKYDEFIRLFE 412
                 899*********99977666667789**********************999889*****9999********************************9766 PP

                 SSSHHHH............HHHHHHHHTTS-HHHHHHHHHHHHHHHH..HHHTHHHH---HHHHHHHHHHHHHT-TS CS
      RhoGAP  86 sedeeer............lealkellekLPkenrdtLryLlehLkr..vaenskenkMtaknLaivfaPtLlrpks 148
                  + + +             le+ k+l+++LP++n+++Lr Ll+ L+   + e++ ++kMt+k +aiv++ +L+  ++
  EFC39526.1 413 PHADVDGitqeaskdyfhvLESTKRLVHTLPQVNQAVLRELLSILRMasIGEYANDTKMTPKTMAIVMSTNLMFVPQ 489
                 6444444566667789999*************************98522778999*****************98776 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 0.35
                 HHHH.HHHTSSSHHHHHHHHHHHHTTS-HHHHH CS
      RhoGAP  78 eeli.eaaksedeeerlealkellekLPkenrd 109
                  el  e  ++ ++e+ +++l e+le   ke+ +
  EFC39526.1 652 IELKkESFNNLQKEDSVKNLTETLEIIQKEKAE 684
                 444433444455555555555555544444443 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.22
                 HHHHHHHHTSSSHHHHHHHHHH CS
      RhoGAP  77 yeelieaaksedeeerlealke 98 
                 ye+ +e+ ++e++e + +  ++
  EFC39526.1 823 YEKALETLRNENQESERKLQQK 844
                 3444433333333333222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (944 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3715  (0.207206); expected 358.6 (0.02)
Passed bias filter:                      522  (0.0291148); expected 358.6 (0.02)
Passed Vit filter:                       169  (0.00942607); expected 17.9 (0.001)
Passed Fwd filter:                        39  (0.00217525); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.42u 0.33s 00:00:01.75 Elapsed: 00:00:00.56
# Mc/sec: 5116.72
//
Query:       EFC39527.1  [L=164]
Description: hypothetical protein NAEGRDRAFT_72699 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0054   16.6   0.0     0.0083   16.0   0.0    1.2  1  F-box-like      F-box-like
  ------ inclusion threshold ------
      0.038   13.0  14.2       0.05   12.6   3.3    2.1  2  DUF5098         Domain of unknown function (DUF5098)
      0.057   13.7   0.9       0.09   13.1   0.9    1.3  1  Synapsin        Synapsin, N-terminal domain
        0.1   12.5   0.8       0.14   12.0   0.1    1.6  2  F-box           F-box domain
       0.11   12.3  16.6       0.65    9.7  16.7    1.8  1  FAM184          Family with sequence similarity 184, A and B
       0.23   11.2  12.2        0.1   12.4   7.9    2.2  2  SKA2            Spindle and kinetochore-associated protein 2
       0.43   10.8  18.6       0.91    9.8   3.3    2.2  2  Seryl_tRNA_N    Seryl-tRNA synthetase N-terminal domain
        1.2    9.5   7.5        1.6    9.1   0.1    3.2  3  PRANC           PRANC domain
        2.2    8.3  13.0        2.8    8.0   3.7    2.4  2  DUF1664         Protein of unknown function (DUF1664)
        3.5    8.2  11.2       0.87   10.2   1.9    2.3  2  DUF1053         Domain of Unknown Function (DUF1053)
        4.6    7.6  21.0          2    8.8   9.6    2.1  2  YlqD            YlqD protein
        8.4    6.6  13.7        6.4    7.0  11.5    2.0  2  Fib_alpha       Fibrinogen alpha/beta chain family


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   5.6e-06    0.0083       3      45 ..       6      48 ..       4      50 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 5.6e-06
  F-box-like  3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrl 45
                +LP E+ ++IFs L+ + L ++    ++ ++       +Wr+l
  EFC39527.1  6 DLPSELQIEIFSILSVKHLGNILSINKKIHEQLVQSETFWRTL 48
                8*********************999999999887777999997 PP

>> DUF5098  Domain of unknown function (DUF5098)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   3.5    0.0027         4     144     214 ..      28      97 ..      10     103 .. 0.86
   2 ?   12.6   3.3   3.4e-05      0.05      49     103 ..     107     161 ..      98     164 .] 0.93

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.0027
     DUF5098 144 eesnellkaeisksdkelqelkkkYkeillnflkiqkahyknll..eevdidrflfdevselkkeifydfpes 214
                  ++n++++++ ++s+  ++ l k+Y +++ +     ++ +++l   e+v++  f   e+ e+kk +  df e 
  EFC39527.1  28 LSINKKIHEQLVQSETFWRTLIKNYSKVIGEKAYRVEQASQELFeiENVKKQ-F--IEMIEMKKRKAEDFQEM 97 
                 5789***************************999999999999977888888.4..67889999989999875 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 3.4e-05
     DUF5098  49 llemsdkqravfdeltrlyeitvvkeldallkkledkiaelneeekkfekklkel 103
                  lem +k+ +  +e++ l + t++ +l++ ++ l+++ + ++++++++e+klk+ 
  EFC39527.1 107 ELEMVQKEMNAQNETVLLLGGTISDQLNNRIESLKQQAESVKKQKEEIEEKLKKT 161
                 47**************************************************987 PP

>> Synapsin  Synapsin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.9     6e-05      0.09      13      88 ..      42     120 ..      33     129 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 6e-05
    Synapsin  13 ktdwskyfrg.kklsGeydirVEqaefselnlvaysdkgl.vvdlkvsrngtkvvrsfkpdfvlvrqhvrd.aagedyr 88 
                 +t w  + ++ +k+ Ge   rVEqa+ + +++ +  ++ + ++++k+++ +     s++ +++l+  ++ + + +++ +
  EFC39527.1  42 ETFWRTLIKNySKVIGEKAYRVEQASQELFEIENVKKQFIeMIEMKKRKAEDFQEMSMQLEYMLIELEMVQkEMNAQNE 120
                 556777777636899****************99977765448999999999999999*******998877733333333 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.1   9.7e-05      0.14       2      26 ..       3      27 ..       2      36 .. 0.85
   2 ?   -3.3   0.1       6.2   9.3e+03      33      38 ..      45      50 ..      43      52 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 9.7e-05
                HHHHS-HHHHHHHHHTS-HHHHHHH CS
       F-box  2 tlsrLPsevlrhILerLplsdllal 26
                ++ +LPse+  +I++ L+ ++l ++
  EFC39527.1  3 NFVDLPSELQIEIFSILSVKHLGNI 27
                5779***************998775 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 6.2
                HHHHHT CS
       F-box 33 wrilid 38
                wr li+
  EFC39527.1 45 WRTLIK 50
                999998 PP

>> FAM184  Family with sequence similarity 184, A and B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  16.7   0.00044      0.65      92     195 ..      57     158 ..      31     163 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00044
      FAM184  92 aehsqkvvelsreveev...krkFeeklrqfaqlqeqle..qekekaLeelrkkhreeveeLlkeqeaqsekllkeqekleekhkaeveklkeeveele 185
                  e + +v + s+e+ e+   k++F e ++     + ++e  qe +  Le +      e+e ++ke +aq+e++l    ++++++++++e+lk+++e+++
  EFC39527.1  57 GEKAYRVEQASQELFEIenvKKQFIEMIE---MKKRKAEdfQEMSMQLEYM----LIELEMVQKEMNAQNETVLLLGGTISDQLNNRIESLKQQAESVK 148
                 44455555666655444000444443333...2222222123444444443....358***************************************** PP

      FAM184 186 kekkklveey 195
                 k+k++++e  
  EFC39527.1 149 KQKEEIEEKL 158
                 ***9998875 PP

>> SKA2  Spindle and kinetochore-associated protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.3      0.23   3.5e+02      54      75 ..      63      84 ..      29      93 .. 0.61
   2 ?   12.4   7.9   6.9e-05       0.1      10      80 ..      93     163 ..      86     164 .] 0.90

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.23
        SKA2 54 lqaLkeqceellaekkelidki 75
                +++ ++++ e+ + kk+ i+ i
  EFC39527.1 63 VEQASQELFEIENVKKQFIEMI 84
                4444444444445555444444 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 6.9e-05
        SKA2  10 lFqkaesdLdyvqhrLekefqqsypdnaeNpvkLlerlk.kvkeelqaLkeqceellaekkelidkirttlv 80 
                  Fq+++ +L+y    Le+  ++  ++n e ++ L   ++ ++++++++Lk+q+e + ++k+e+ +k+++t++
  EFC39527.1  93 DFQEMSMQLEYMLIELEMVQKEMNAQN-ETVLLLGGTISdQLNNRIESLKQQAESVKKQKEEIEEKLKKTII 163
                 59***************9999999998.5999999999747*************************999875 PP

>> Seryl_tRNA_N  Seryl-tRNA synthetase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   3.3   0.00061      0.91      28     104 ..      24     101 ..      19     102 .. 0.86
   2 ?    5.7  11.5     0.012        17      28     100 ..      91     161 ..      86     164 .] 0.82

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00061
                   HHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCTS CS
  Seryl_tRNA_N  28 vdelleldekrrelqveleel.qaerNelskeIgkakkkkedaeeliaevkelkeelkaleaelkeleaeleklllai 104
                   +  +l++++k  e  v+ e + ++  ++ sk Ig++  + e+a++ + e++++k+++ ++ +  k   ++++++ +++
    EFC39527.1  24 LGNILSINKKIHEQLVQSETFwRTLIKNYSKVIGEKAYRVEQASQELFEIENVKKQFIEMIEMKKRKAEDFQEMSMQL 101
                   56788888888888888887548899************99******************99999999999998887765 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.012
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCTTS-TCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH CS
  Seryl_tRNA_N  28 vdelleldekrrelqveleelqaerNelskeIgkakkkkedaeeliaevkelkeelkaleaelkeleaelekl 100
                    +++ e+  + + + +ele +q+e N+ ++++  +       ++l +++++lk++ + ++++ +e+e++l+k 
    EFC39527.1  91 AEDFQEMSMQLEYMLIELEMVQKEMNAQNETVLLLGGT--ISDQLNNRIESLKQQAESVKKQKEEIEEKLKKT 161
                   577888889999999****************9888875..477888888888888888888888888888875 PP

>> PRANC  PRANC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.1    0.0011       1.6      72      96 ..       4      28 ..       1      29 [. 0.90
   2 ?    1.3   0.2       0.3   4.5e+02      25      62 ..      32      70 ..      29      88 .. 0.56
   3 ?    2.0   0.4      0.18   2.7e+02      40      68 ..     132     160 ..     127     163 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0011
       PRANC 72 WnlLPiEIkykIleyLndkdLknll 96
                   LP E++++I++ L+ k+L n+l
  EFC39527.1  4 FVDLPSELQIEIFSILSVKHLGNIL 28
                568******************9997 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.3
       PRANC 25 kkklkklk.slkiYgklikkiiksakkrykliekaievl 62
                kk   +l  s ++++ lik+  k + ++   +e+a++ l
  EFC39527.1 32 KKIHEQLVqSETFWRTLIKNYSKVIGEKAYRVEQASQEL 70
                333444432335555555555555555555555555544 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.18
       PRANC  40 likkiiksakkrykliekaievlnnicsk 68 
                  +++ i+s+k+  + ++k  e ++++++k
  EFC39527.1 132 QLNNRIESLKQQAESVKKQKEEIEEKLKK 160
                 67899999******999999999999887 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   3.7    0.0019       2.8      56     112 ..      62     117 ..      46     131 .. 0.62
   2 ?    6.0   1.4    0.0079        12      62      90 ..     131     159 ..     127     162 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0019
     DUF1664  56 slaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveg 112
                  ++++ ++L  +i++v k+  e++e++k  +e+ +e++ +l+ +  ++e v++ ++ 
  EFC39527.1  62 RVEQASQELF-EIENVKKQFIEMIEMKKRKAEDFQEMSMQLEYMLIELEMVQKEMNA 117
                 4555555554.4777777777777777777777777777777766666666665444 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0079
     DUF1664  62 rhLssridrvdkkldeqkeiskeikeevt 90 
                 ++L++ri+++ ++ +++k+ ++ei+e+++
  EFC39527.1 131 DQLNNRIESLKQQAESVKKQKEEIEEKLK 159
                 56778888888888888888888887765 PP

>> DUF1053  Domain of Unknown Function (DUF1053)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   2.5       0.1   1.5e+02      54      85 ..      71     100 ..      31     112 .. 0.75
   2 ?   10.2   1.9   0.00058      0.87      28      64 ..     121     162 ..     106     164 .] 0.79

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.1
     DUF1053  54 eelderleqaIdglsskklwkrsedlkkftli 85 
                  e+++  +q I+++  kk   + ed++++++ 
  EFC39527.1  71 FEIENVKKQFIEMIEMKKR--KAEDFQEMSMQ 100
                 4778888899999999999..9****998865 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00058
     DUF1053  28 ri.....eiplkksklqdkkersasekarleeelderleqaI 64 
                 ++      i ++ +++ ++++++a+++++++ee++e+l+++I
  EFC39527.1 121 TVlllggTISDQLNNRIESLKQQAESVKKQKEEIEEKLKKTI 162
                 33566667888888888999*******************998 PP

>> YlqD  YlqD protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   9.6    0.0013         2      21     102 ..      30     117 ..      28     122 .. 0.92
   2 ?    4.6   3.5     0.026        39      22      50 ..     130     158 ..     125     163 .. 0.49

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0013
        YlqD  21 lqqqlqaqieqldkelqqLefqakrlikeikkqsaq......qieeiqeqvekekserlekkkqllqqleqvqkLelgsevkqgqves 102
                 + +++++q+ q ++ ++ L  +  ++i e++   +q      +ie++++q+ + ++  + k +++++   q++ + ++ e++q+++++
  EFC39527.1  30 INKKIHEQLVQSETFWRTLIKNYSKVIGEKAYRVEQasqelfEIENVKKQFIEMIEMKKRKAEDFQEMSMQLEYMLIELEMVQKEMNA 117
                 567899999999999999999999999999988887899999*******************************************987 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.026
        YlqD  22 qqqlqaqieqldkelqqLefqakrlikei 50 
                  +ql+++ie l+++ + ++ q++++++++
  EFC39527.1 130 SDQLNNRIESLKQQAESVKKQKEEIEEKL 158
                 34444444444444444444444444444 PP

>> Fib_alpha  Fibrinogen alpha/beta chain family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       1.2   1.8e+03      89     113 ..      26      51 ..      19      58 .. 0.59
   2 ?    7.0  11.5    0.0043       6.4      35     127 ..      54     146 ..      42     162 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.2
                 CCCHHHHHHHCCH.HHHHHHHHHHHH CS
   Fib_alpha  89 eilrlketidaqe.snirvLqnvles 113
                 +il ++++i +q  ++  + ++++++
  EFC39527.1  26 NILSINKKIHEQLvQSETFWRTLIKN 51 
                 67777777777775554444554444 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0043
                 HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHH.HHHHHHHHHHHHH CS
   Fib_alpha  35 kdlekleneleeisnstkeaeelvkeikdslrekqkskkdndnvikksskeleeeilrlketidaqesnirvLqnvlesn.eqkiqkLeqdidq 127
                 k + +   ++e++s++  e+e++ k+  ++++ k+++++d +++  +++ +l  e + ++++++aq +++  L ++++++ +++i+ L+q+ ++
  EFC39527.1  54 KVIGEKAYRVEQASQELFEIENVKKQFIEMIEMKKRKAEDFQEMSMQLEYMLI-ELEMVQKEMNAQNETVLLLGGTISDQlNNRIESLKQQAES 146
                 555555668999999999*********************99***********9.9******************99887653789*****98765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (164 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3214  (0.179263); expected 358.6 (0.02)
Passed bias filter:                      726  (0.0404931); expected 358.6 (0.02)
Passed Vit filter:                        97  (0.00541023); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.68u 0.34s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 916.29
//
Query:       EFC39528.1  [L=743]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-21   76.7   0.7    1.6e-21   76.7   0.7    1.6  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.0      0.47   8.5e+03      50      68 ..     396     414 ..     388     421 .. 0.75
   2 !   76.7   0.7     9e-26   1.6e-21       8     180 ..     535     713 ..     529     715 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 0.47
  Guanylate_cyc  50 kvykvktiGdaymvvsglp 68 
                    k+ +v+t+ d+y  ++ + 
     EFC39528.1 396 KIVEVSTVRDTYNLTCTVV 414
                    5889999999998887765 PP

  == domain 2  score: 76.7 bits;  conditional E-value: 9e-26
  Guanylate_cyc   8 evtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevaves....ke 98 
                    ++t+l++ I++f++ls++++  + ++++ e+y+++ ++++++ +  +k+i  + mv  + +  ++a+h +++++ a++ +e +e  + +       
     EFC39528.1 535 SMTVLYCGINNFATLSEKTETTAFIRIITEYYSSISQVIEAHCGIIDKFIEGTVMVFWNEKsFRCANHESRACKTAIECMEVIEDLNSKWkilmGI 630
                    79******************************************************988775789999***************9888887465569 PP

  Guanylate_cyc  99 glkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgka.gkiqvseetyellkeeqfeltergevevkGkgkletyf 180
                    +l++ +Gi +G++++g++G ++++ ++v+G++ n+A r++s++++ g i vs e ++  + e+f ++ ++  +++Gk++ ++++
     EFC39528.1 631 QLDISIGITCGEMLVGCLGsKSRMSFTVIGDECNIALRLQSLAQNfGSILVSGEIVDKVR-EEFIFHFVDLLKLRGKSNSTCIY 713
                    9******************999*********************86599***********9.***************99988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (743 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       999  (0.0557198); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 4147.79
//
Query:       EFC39529.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.037   14.3   0.3      0.057   13.7   0.3    1.2  1  EI24      Etoposide-induced protein 2.4 (EI24)


Domain annotation for each model (and alignments):
>> EI24  Etoposide-induced protein 2.4 (EI24)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.3   3.2e-06     0.057      95     155 ..     213     276 ..     200     280 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3.2e-06
                 HHHHHHHHHHHHHH.HHTTHHH....HHHHH..HHHHHHHHHHHHHHHHH-HHHHHHHHHCTHH CS
        EI24  95 lllllllllvllpl.liPvvglilsplllsw..ltayfycfeyldlaagrsleerrallerrra 155
                 +l+++l+ +++l l ++ ++ ++ +p++l++   + ++  +e+ d+ ++++  +r ++l+++ +
  EFC39529.1 213 ILMVILCIILVLSLaILAGIYIVTAPIALFLivYYEKITIIEFDDEKREVRMTSRARYLREHFI 276
                 7888999999999987788998888888888444556799********************9965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1318  (0.0735122); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.33s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2260.92
//
Query:       EFC39530.1  [L=290]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00015   21.4   0.0    0.00063   19.4   0.0    2.1  1  HeH       HeH/LEM domain
  ------ inclusion threshold ------
      0.044   13.5   0.0      0.088   12.5   0.0    1.5  1  PTCRA     Pre-T-cell antigen receptor


Domain annotation for each model (and alignments):
>> HeH  HeH/LEM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0     7e-08   0.00063       5      32 ..       7      35 ..       6      38 .. 0.89

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 7e-08
         HeH  5 tVaqLRriLvehgveyPsnaK.KadLveL 32
                tVa L++iL e+++e+P  a  Ka Lv+L
  EFC39530.1  7 TVAGLKEILEENNIEIPKGAHlKAHLVKL 35
                9****************999768888887 PP

>> PTCRA  Pre-T-cell antigen receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   9.8e-06     0.088      33     108 ..     204     277 ..     198     288 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 9.8e-06
       PTCRA  33 vappgldspiwfsaGnGsaldaftyGpspaadGtwtslaqlslpseelaaweplvchtgpgageksrstqplqlsg 108
                 + + +  +++ f     ++ d+ t G + ++d  +++ +++ l+ e+ ++ e++v +t+ +++ ++r t+p++l  
  EFC39530.1 204 IQAGNSTNNVKFNNNTNTTNDTNTQGTTTSSDAIYAN-TRIKLENEDKES-ETIVKKTKIKSDVENRITKPIKLRK 277
                 66777889999*99999*****************987.699*****9988.9*********************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (290 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1990  (0.110993); expected 358.6 (0.02)
Passed bias filter:                      279  (0.0155614); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.34s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 1609.71
//
Query:       EFC39531.1  [L=484]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      5e-61  205.8   0.0    8.2e-61  205.1   0.0    1.3  1  SRP54           SRP54-type protein, GTPase domain
    2.5e-21   76.1   0.8    7.1e-21   74.7   0.1    2.1  1  SRP_SPB         Signal peptide binding domain
    1.6e-12   47.5   4.1    1.6e-12   47.5   4.1    2.7  3  SRP54_N         SRP54-type protein, helical bundle domain
    0.00041   20.5   0.0    0.00074   19.7   0.0    1.4  1  AAA_33          AAA domain
    0.00082   18.4   0.1     0.0026   16.8   0.0    1.8  2  MeaB            Methylmalonyl Co-A mutase-associated GTPase M
     0.0038   16.6   0.0     0.0099   15.2   0.0    1.8  1  6PF2K           6-phosphofructo-2-kinase
      0.004   16.2   0.1     0.0072   15.4   0.1    1.3  1  Glyco_hydro_53  Glycosyl hydrolase family 53
  ------ inclusion threshold ------
      0.011   15.7   0.1      0.036   13.9   0.0    1.8  2  APS_kinase      Adenylylsulphate kinase
      0.012   16.0   0.0      0.032   14.6   0.0    1.7  1  AAA_16          AAA ATPase domain
      0.015   14.9   1.0       0.34   10.5   1.0    2.4  1  cobW            CobW/HypB/UreG, nucleotide-binding domain
      0.018   15.3   0.3       0.06   13.6   0.1    2.1  2  AAA_22          AAA domain
      0.051   13.6   0.2       0.15   12.1   0.2    1.9  1  AAA_14          AAA domain
      0.057   13.3   1.4        1.7    8.5   0.1    2.7  2  AAA_31          AAA domain
      0.066   12.9   0.2       0.19   11.4   0.2    1.9  1  AAA_24          AAA domain
      0.075   12.7   0.0       0.24   11.1   0.0    1.9  2  AAA_30          AAA domain
      0.082   13.3   2.3       0.11   12.9   0.4    2.2  1  AAA_17          AAA domain
       0.11   12.3   1.1       0.23   11.2   0.2    2.0  2  ATP_bind_1      Conserved hypothetical ATP binding protein
       0.13   12.4   1.2       0.19   11.8   0.2    1.8  2  Xpo1            Exportin 1-like protein
       0.13   12.6   0.2       0.44   10.8   0.2    1.9  1  ArgoMid         Mid domain of argonaute
       0.14   11.7   0.1        3.4    7.2   0.1    2.4  2  AAA_25          AAA domain
       0.81   10.1   3.6        1.1    9.7   0.3    2.9  3  AAA             ATPase family associated with various cellula


Domain annotation for each model (and alignments):
>> SRP54  SRP54-type protein, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  205.1   0.0   9.6e-64   8.2e-61       2     196 .]     100     295 ..      99     295 .. 0.98

  Alignments for each domain:
  == domain 1  score: 205.1 bits;  conditional E-value: 9.6e-64
                 EEEEEEESTTSSHHHHHHHHHHHHHHTTS-EEEEEESTSSTTHHHHHHHHHHHTTEEEEESSTTSCHHHHHHHHHHHHHHTTSSEEEEEE--SSTTHHH CS
       SRP54   2 nvillvGlqGaGKTttlaKLaallkkegkkvllvaaDtfRaaAveQLktlaeklgvpvikkkeeadpaavakeavekakeekidvvlvDTaGrlqndke 100
                 nvil++Gl GaGKTtt++K a  +kk+g k+++v   tfR +A++ L+++  +  +p++++  e+dp+++ak++ve++k+e++d+++vDT+ r  ++++
  EFC39531.1 100 NVILFIGLRGAGKTTTASKFAMFYKKKGFKCAIVNSNTFRTGAFDSLRHNSLRDTIPFYGNVFETDPIKIAKDGVETFKKENYDLIIVDTSARTIQEES 198
                 89************************************************************************************************* PP

                 HHHHHHHHHHHHSSSEEEEEEETTBHTHHHHHHHHHHHHS.SCSEEEEESTTSSSSTTHHHHHHHHHTS-EEEEE-SSSTTGEEE--HHHHHHHHHT CS
       SRP54 101 lmeelkkikkvvkpdevllvldattgqeavkqakaFkeav.gitgviltklDgdakgGaalsiaaelklPikfigvGekiedleefdperlvsrllg 196
                 l+ee+k i+++++p++++lv+d+ +gq+  +q+++Fk+++  ++++iltklDg++kgG+als+ a++k+Pi+fig+Ge ++ l++f+ e +vsrllg
  EFC39531.1 199 LFEEMKLISEAITPNDIILVMDSKIGQSIKEQVTTFKSRIpTLGSIILTKLDGHSKGGGALSAIAATKTPISFIGTGEYYDSLQPFEVEGFVSRLLG 295
                 **************************************9957999**************************************************95 PP

>> SRP_SPB  Signal peptide binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.7   0.1   8.4e-24   7.1e-21       2      97 ..     328     425 ..     327     426 .. 0.89

  Alignments for each domain:
  == domain 1  score: 74.7 bits;  conditional E-value: 8.4e-24
                 SCTHHHHHHHHHHHCCCCCCHHHHCCC......H...CCCCCHHHHHHHHHTTSBHHHHHSGCG-......HHHHHHHHHHTTS-HHHHHHHHHHHHHH CS
     SRP_SPB   2 ftlrdlleqlqqikkmGplskllsmiPgmsae.akaeeeaekklkrieaiidSMTkeErdspekllk....esRkrRiArGsGtsvqevnellkqfeqm 95 
                 ft+rdl+eql +i +mGp s++lsmi g+s+  +   e +e k+k++ +i+ SM + E+d  + + k    +sR+ RiArGsG + ++v ell++++q+
  EFC39531.1 328 FTMRDLKEQLLSIVNMGPPSRVLSMIFGFSEFpK--IEGQEYKVKKYLTIMGSMNETELDCAD-FTKlsdmQSRILRIARGSGKNSKDVVELLDNYKQF 423
                 9***************************886653..344589*******************99.55455556**************************9 PP

                 HH CS
     SRP_SPB  96 kk 97 
                 ++
  EFC39531.1 424 QS 425
                 86 PP

>> SRP54_N  SRP54-type protein, helical bundle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.5   4.1   1.9e-15   1.6e-12       1      75 []       6      81 ..       6      81 .. 0.93
   2 ?   -0.9   0.1       2.3     2e+03      15      55 ..     191     230 ..     187     237 .. 0.73
   3 ?   -2.3   0.0       6.5   5.6e+03       3      23 ..     437     456 ..     436     463 .. 0.65

  Alignments for each domain:
  == domain 1  score: 47.5 bits;  conditional E-value: 1.9e-15
                HHHHHHHHHHHHCCSSCGHHHHHHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHCTTS.S-HHHHHHHHHHHHH CS
     SRP54_N  1 LgkklnsalkklsgkskideedleealkeleeaLleaDVgvkvvkklienvkkkavgekk.lkpkqqvkkivkdeL 75
                L+++l++al  ++++s+ d++ ++ +lke+ +aLleaDV+ + v ++ + +k++  ++++ +++k+ +k+i+k+eL
  EFC39531.1  6 LSSQLSNALLTIHSQSVMDDKSVNKFLKEISKALLEADVNCEQVVQVYNGIKEELDNMSQdVNRKKNIKRILKKEL 81
                799************************************************9966444448*************98 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 2.3
                 SSCGHHHH.HHHHHHHHHHHHHHTT--HHHHHHHHHHHHHHH CS
     SRP54_N  15 kskideed.leealkeleeaLleaDVgvkvvkklienvkkka 55 
                 +++i ee  +ee +k + ea   +D+ + + +k+ +++k+ +
  EFC39531.1 191 ARTIQEESlFEE-MKLISEAITPNDIILVMDSKIGQSIKE-Q 230
                 567877773555.999999988888877777777777766.4 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 6.5
                 HHHHHHHHHHCCSSCGHHHHH CS
     SRP54_N   3 kklnsalkklsgkskideedl 23 
                 +k+++a++ ++++ ++   d+
  EFC39531.1 437 SKIQDAFNTFRNN-ELEHLDW 456
                 7999999986655.4555555 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   0.0   8.6e-07   0.00074       1      72 [.     101     183 ..     101     208 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 8.6e-07
      AAA_33   1 lvllvGlpGsGKstlaerl...lkklg..avllssdtlrrrlfg.....tdqqsktdytr.vldrlyqilnelarkalsagrn 72 
                 ++l++Gl G+GK+t a +    +kk g  + +++s+t+r+  f      + ++++  y + ++++ ++i ++ ++   +++++
  EFC39531.1 101 VILFIGLRGAGKTTTASKFamfYKKKGfkCAIVNSNTFRTGAFDslrhnSLRDTIPFYGNvFETDPIKIAKDGVETFKKENYD 183
                 89****************86767888899***********9999433332233333333312233444555555555555555 PP

>> MeaB  Methylmalonyl Co-A mutase-associated GTPase MeaB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0     3e-06    0.0026      20      64 ..      90     134 ..      86     152 .. 0.91
   2 ?   -3.2   0.0       3.9   3.3e+03     207     232 ..     402     427 ..     374     453 .. 0.54

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 3e-06
                 HHHGGG-S-SEEEEEEE-TTSSHHHHHHHHHHHHHCTT--EEEEE CS
        MeaB  20 erllakaGraqvvGltGvPGaGkstlvealglelrrrGkrvavla 64 
                 +++ +  G+ +v+ + G+ GaGk t+ +++++ ++++G + a++ 
  EFC39531.1  90 KAIKPVKGKQNVILFIGLRGAGKTTTASKFAMFYKKKGFKCAIVN 134
                 6788999***********************************984 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 3.9
                 EEEEBCCCTBSHHHHHHHHHHHHHHH CS
        MeaB 207 vlktsavegeGidelvdaieehrevl 232
                 + + s+++ + + el+d+ ++++++ 
  EFC39531.1 402 IARGSGKNSKDVVELLDNYKQFQSTN 427
                 23333344444444444444444333 PP

>> 6PF2K  6-phosphofructo-2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   1.2e-05    0.0099       9      59 ..      95     145 ..      89     221 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.2e-05
                 T..S-EEEEEESSTTSSHHHHHHHHHHHHHHTT--EEEEEHHHHHHHHHSS CS
       6PF2K   9 lknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreaska 59 
                  k ++ vi+++GL+  gKt++++k   + k  g+++ + n   +r  a  +
  EFC39531.1  95 VKGKQNVILFIGLRGAGKTTTASKFAMFYKKKGFKCAIVNSNTFRTGAFDS 145
                 5677889******************************99999888766555 PP

>> Glyco_hydro_53  Glycosyl hydrolase family 53
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.1   8.4e-06    0.0072     112     205 ..      25     129 ..      17     156 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 8.4e-06
  Glyco_hydro_53 112 kkavydyTkdvlkklkeagvlpel.VqvGNEinsgllwsegk...kenwek.....lakllnsgikavkevstnikvviHl..angedaaskkai 195
                     +k v ++ k++ k+l ea+v+ e+ Vqv N i+++l + +++   k+n ++     l+kl+  g+ka+k v+ + +v++ +      ++++ + +
      EFC39531.1  25 DKSVNKFLKEISKALLEADVNCEQvVQVYNGIKEELDNMSQDvnrKKNIKRilkkeLCKLFDPGVKAIKPVKGKQNVILFIglRGAGKTTTASKF 119
                     678999**************987527******999866555556766665411112799***********9999999876511455555556666 PP

  Glyco_hydro_53 196 fkklskagvd 205
                     + + +k+g +
      EFC39531.1 120 AMFYKKKGFK 129
                     6666666655 PP

>> APS_kinase  Adenylylsulphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       2.8   2.4e+03      52      64 ..      65      77 ..      34      87 .. 0.69
   2 ?   13.9   0.0   4.3e-05     0.036       3      48 ..     100     145 ..      98     152 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.8
                SHHHHHHHHHHHH CS
  APS_kinase 52 seedRkenirrva 64
                ++ +Rk+ni+r+ 
  EFC39531.1 65 QDVNRKKNIKRIL 77
                4457999999984 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 4.3e-05
                 EEEEEESSTTSSHHHHHHHHHHHHHHTT--EEEEEHHHHTTTTTTT CS
  APS_kinase   3 vvvwltGlsgsGKstianalekkLvekgisvylLdGdnvRhgLnkd 48 
                  v+++ Gl g+GK+t a +++   ++kg ++ +++ ++ R+g    
  EFC39531.1 100 NVILFIGLRGAGKTTTASKFAMFYKKKGFKCAIVNSNTFRTGAFDS 145
                 6899*********************************999986655 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   3.8e-05     0.032      19      52 ..      95     135 ..      89     221 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 3.8e-05
      AAA_16  19 vrsgrpelvllsGesGvGKsslvrellralekd........g 52 
                 v +g  +++l++G +G GK++ + +++  ++k+         
  EFC39531.1  95 V-KGKQNVILFIGLRGAGKTTTASKFAMFYKKKgfkcaivnS 135
                 4.56669********************999999444333321 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   1.0   0.00039      0.34       2     155 ..     101     254 ..     100     268 .. 0.70

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00039
                 EEEEEESTTCCHHHHHHHHH..CT--SS-EEEEESS-SSCHCCCCCCHCCCT.EEEETTTTECCH.CTT-HHHHHHHHHHHHTT-SEEEEEECTTTTHH CS
        cobW   2 vtvltGflGsGKTtLlnhll..enraglklavivNefgevsiDaellretgveivelenGciCct.lredllkelealeereerldviliEttGlaePa 97 
                 v+++ G  G+GKTt  ++     +++g k+a++  +   ++   +l +++   ++ +  G +  t   + +   +e ++++  ++d+i++ t+      
  EFC39531.1 101 VILFIGLRGAGKTTTASKFAmfYKKKGFKCAIVNSNTFRTGAFDSLRHNSLRDTIPF-YGNVFETdPIKIAKDGVETFKKE--NYDLIIVDTSARTIQE 196
                 566778889999999998888888899999988655444544434433443334444.35555552333344444444444..59********966666 PP

                 HHHTT.SHHHHHCCCECEEEEEEETTTH.CCHCCHHHHHHHHHHTSSEEEEE-HHHHCH CS
        cobW  98 pvaft.eeelksdltldavvavvDaknleaeeekieekaedqlaaadllvlnKtDllde 155
                 +++f+  + +++++t + ++ v+D+ ++ ++ +++ +++++ + +   ++l+K D  ++
  EFC39531.1 197 ESLFEeMKLISEAITPNDIILVMDS-KIGQSIKEQVTTFKSRIPTLGSIILTKLDGHSK 254
                 66577466677799999********.66689999999*****************98766 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1     7e-05      0.06       4      31 ..      98     125 ..      95     218 .. 0.88
   2 ?   -3.0   0.0       9.2   7.9e+03      46      78 ..     385     416 ..     379     430 .. 0.66

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 7e-05
      AAA_22   4 tagilvvtGesGtGKTtllrrlleqlde 31 
                 ++++++ +G  G+GKTt++ ++++ +++
  EFC39531.1  98 KQNVILFIGLRGAGKTTTASKFAMFYKK 125
                 7899*******************99853 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 9.2
      AAA_22  46 tlpsstsskdllrellralglelkaerlsseel 78 
                 +++  t+++d+ +++lr+   ++k+  ++  el
  EFC39531.1 385 DCADFTKLSDMQSRILRIARGSGKN-SKDVVEL 416
                 6777777777777777777765555.4444444 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.2   0.00018      0.15       2      49 ..      99     154 ..      98     241 .. 0.67

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00018
      AAA_14   2 rkilvitGaRrvGKTtllkqlikell........vkkesilyinldderdkkladp 49 
                 +++++  G+R +GKTt + +++  +         v+++ +   ++d+ r  +l+d+
  EFC39531.1  99 QNVILFIGLRGAGKTTTASKFAMFYKkkgfkcaiVNSNTFRTGAFDSLRHNSLRDT 154
                 578999************99974444456777777777777777777777666654 PP

>> AAA_31  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.1     0.002       1.7      12      37 ..     109     134 ..      99     155 .. 0.87
   2 ?    2.7   0.1      0.12     1e+02     109     126 ..     172     190 ..     160     195 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.002
      AAA_31  12 GvGKTTtsvnlaaalaklgkkvLlvD 37 
                 G GKTTt+ ++a++  k+g k  +v+
  EFC39531.1 109 GAGKTTTASKFAMFYKKKGFKCAIVN 134
                 79*******************98886 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.12
      AAA_31 109 ellekvk.deYDyiiiDcp 126
                 + +e++k ++YD+ii+D++
  EFC39531.1 172 DGVETFKkENYDLIIVDTS 190
                 5566665156*******86 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.2   0.00022      0.19       3      74 ..     100     190 ..      98     233 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00022
      AAA_24   3 lkiliyGpsgiGKTtlakel.......gpkplfidtek.Glksldadkfpdie..swedfldevvel..............aaeladyktlviDti 74 
                 + il +G  g+GKTt+a+++       g k ++++ +   + + d       +  s+ d + ++  +                ++++y+ +++Dt 
  EFC39531.1 100 NVILFIGLRGAGKTTTASKFamfykkkGFKCAIVNSNTfRTGAFDSL-----RhnSLRDTIPFYGNVfetdpikiakdgveTFKKENYDLIIVDTS 190
                 679999**************777644322333332222223333333.....23344444444444466678888888888778889999999985 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00028      0.24      13      51 ..      95     132 ..      89     199 .. 0.87
   2 ?   -2.1   0.0       3.1   2.6e+03     145     177 ..     422     453 ..     410     458 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00028
      AAA_30  13 lltsgdrvavltGpAGtGKttalkalreaweaaggrvig 51 
                 + ++ + v +  G  G+GKtt+ ++ +  ++++g++ ++
  EFC39531.1  95 VKGK-QNVILFIGLRGAGKTTTASKFAMFYKKKGFKCAI 132
                 4444.459999*********************9987655 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 3.1
      AAA_30 145 gigtaeLtevvRqkeseeraaalalregdaeea 177
                 ++++++  +++R k+s++++a + +r+++ e  
  EFC39531.1 422 QFQSTNHPNIIRKKSSKIQDAFNTFRNNELE-H 453
                 5555555679999999999999999998876.4 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.4   0.00013      0.11       1     111 [.     105     221 ..     105     233 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 0.00013
                 EE-TTSSHHHHHHHHH...HHHTEEE.EEHHHHHHHHHHTT.TSHSSHHHHC...TSHHHHHHHHHHHHHHHHHHHHHSSEEEEEE-SEEEETTEEEES CS
      AAA_17   1 lGgPGsGKgtqceklv...ekygfth.lsaGdllreeakrg.glakardemr...klpleekkelqkeaaekiaeeakkkgvlvdghprikeqagfldg 91 
                 +G+ G+GK+t ++k +   +k gf+  +  +  +r  a ++   ++ rd +    ++ + +  ++ k   e+ ++e + + ++vd+ +r+ +++ ++++
  EFC39531.1 105 IGLRGAGKTTTASKFAmfyKKKGFKCaIVNSNTFRTGAFDSlRHNSLRDTIPfygNVFETDPIKIAKDGVETFKKE-NYDLIIVDTSARTIQEESLFEE 202
                 5999***********9444444666423448888866654423344556555433555555555666666666655.45679**********9999999 PP

                 SHHHHHHHH..SEEEEEE-- CS
      AAA_17  92 lpkevleelkpdaiillead 111
                 ++  + e + p+ iil+ ++
  EFC39531.1 203 MKL-ISEAITPNDIILVMDS 221
                 997.8899999888887654 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.2   0.00027      0.23       2      31 ..     105     134 ..     104     137 .. 0.96
   2 ?   -2.7   0.0       4.9   4.2e+03     183     217 ..     392     426 ..     366     438 .. 0.56

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00027
  ATP_bind_1   2 vGpaGsGKttfvgalseilelrgrsvavvN 31 
                 +G  G+GKtt  ++++ +++++g ++a+vN
  EFC39531.1 105 IGLRGAGKTTTASKFAMFYKKKGFKCAIVN 134
                 899**************************9 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 4.9
  ATP_bind_1 183 vealslllekeeekykklaeaiaelleefalvlrf 217
                 + +++  +    +   k+ ++++ell++++  +++
  EFC39531.1 392 LSDMQSRILRIARGSGKNSKDVVELLDNYKQFQST 426
                 22333222222244556666677777766666555 PP

>> Xpo1  Exportin 1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   0.00022      0.19       5      82 ..       7      83 ..       4      99 .. 0.80
   2 ?   -2.4   0.1       5.1   4.3e+03      59     104 ..     389     439 ..     368     455 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00022
                HHHHHHHHHHHHHHHT..TTTSTTHHHHHHHHHCT.HHHHHHHHHHHHHHHHHHHTSHTTTSCHHHHHHHHHHHHHHHHH CS
        Xpo1  5 rnklaealaelflqey..pnnWpsffddllsllssspsglelllriLkvlpeEiadfsrskleqerrndlkdllrsnvqk 82
                 ++l+ al ++  q     ++ ++f++++ ++l   +  +e + ++ + ++eE+ ++s+     +r++++k+ l++++ k
  EFC39531.1  7 SSQLSNALLTIHSQSVmdDKSVNKFLKEISKALLEADVNCEQVVQVYNGIKEELDNMSQ---DVNRKKNIKRILKKELCK 83
                67888888888888875567899*******999999******************87765...456666666666665444 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 5.1
                 SHTTTSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC.....HHHHHH CS
        Xpo1  59 fsrskleqerrndlkdllrsnvqkilelllqileqsqskk.....qsselv 104
                 f + +  q+r  ++ +   +n ++++ell ++ + +++++     ++s+ +
  EFC39531.1 389 FTKLSDMQSRILRIARGSGKNSKDVVELLDNYKQFQSTNHpniirKKSSKI 439
                 555455555555555555555666666666665555544444444444444 PP

>> ArgoMid  Mid domain of argonaute
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.2   0.00051      0.44      25      83 ..      13      69 ..       9      70 .. 0.88

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00051
     ArgoMid 25 Ailcfasqrkvkenkledfikqlvkiskdvgisleekpeirkyadderevetlfkdlkk 83
                A+l+ +sq+ ++++++++f+k++ k + +++++ e  + +  y+  ++e++++ +d+++
  EFC39531.1 13 ALLTIHSQSVMDDKSVNKFLKEISKALLEADVNCE--QVVQVYNGIKEELDNMSQDVNR 69
                789999***********************998765..5677799999999999999877 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.1     0.004       3.4      26      55 ..      92     121 ..      86     129 .. 0.85
   2 ?    1.7   0.0      0.19   1.6e+02     135     156 ..     175     195 ..     153     202 .. 0.84

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.004
      AAA_25  26 vkgllpagelallaGapgtGKttlaldlal 55 
                 +k +  ++ ++l++G +g+GKtt a+  a 
  EFC39531.1  92 IKPVKGKQNVILFIGLRGAGKTTTASKFAM 121
                 5666678899***************99886 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.19
      AAA_25 135 aaieevegvrlvviDplsralg 156
                 ++ ++ e+++l+++D+ +r+ +
  EFC39531.1 175 ETFKK-ENYDLIIVDTSARTIQ 195
                 56777.89********999876 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       4.4   3.8e+03      84      95 ..      26      37 ..       2      86 .. 0.58
   2 ?    9.7   0.3    0.0013       1.1       1     109 [.     102     265 ..     102     285 .. 0.53
   3 ?   -2.1   0.0       5.6   4.8e+03      70      70 ..     423     423 ..     376     451 .. 0.51

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 4.4
                HHHHHHHHHHHH CS
         AAA 84 rvvnqLlteldg 95
                + vn++l+e+++
  EFC39531.1 26 KSVNKFLKEISK 37
                333333333322 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.0013
                 EEEESSTTSSHHHHHHHHHHHHT...HEEEEEETTTCSSS............................................STTHHHHHHHH..HH CS
         AAA   1 vllyGppGtGKTllakavakelg...vefleisgsellsk............................................yvgesekkire..lf 50 
                 +l++G  G GKT++a+  a   +   +++  ++  +++                                              +v  s++ i+e  lf
  EFC39531.1 102 ILFIGLRGAGKTTTASKFAMFYKkkgFKCAIVNSNTFRTGafdslrhnslrdtipfygnvfetdpikiakdgvetfkkenydliIVDTSARTIQEesLF 200
                 69**************99988742234444444444442234444444555555555555555555555556666666666666555555555432255 PP

                 HHHHHTS...TS..EEEEEET.GGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEE CS
         AAA  51 keakeka...kp..silfiDE.idalaksrsgseseeeervvnqLlteldgvkkkeskvivigat 109
                 +e+k  +   +p   il++D  i + +k++ ++ ++   ++ + +lt+ldg +k  + +  i+at
  EFC39531.1 201 EEMKLISeaiTPndIILVMDSkIGQSIKEQVTTFKSRIPTLGSIILTKLDGHSKGGGALSAIAAT 265
                 55544444553331444444223333333322223333344566666666666664444444444 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 5.6
                 H CS
         AAA  70 l 70 
                 +
  EFC39531.1 423 F 423
                 2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (484 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1147  (0.0639746); expected 358.6 (0.02)
Passed bias filter:                      798  (0.0445089); expected 358.6 (0.02)
Passed Vit filter:                       119  (0.00663729); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              21  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.48
# Mc/sec: 3010.59
//
Query:       EFC39532.1  [L=1822]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.3e-08   32.8   6.4    7.3e-08   32.8   6.4    2.4  2  GPS        GPCR proteolysis site, GPS, motif
      4e-07   30.3  77.1      0.042   14.2   9.0    6.1  6  EGF_2      EGF-like domain
    6.1e-06   26.5   6.2    9.4e-06   25.9   0.2    3.7  3  RGS        Regulator of G protein signaling domain
  ------ inclusion threshold ------
       0.54   10.6   9.8        1.1    9.5   9.8    1.4  1  RSB_motif  RNSP1-SAP18 binding (RSB) motif
        7.7    6.2  13.3      0.056   13.2   0.6    3.1  3  Claudin_2  PMP-22/EMP/MP20/Claudin tight junction


Domain annotation for each model (and alignments):
>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.4   2.7         5   1.8e+04       2      22 ..     211     230 ..     211     239 .. 0.67
   2 !   32.8   6.4     2e-11   7.3e-08       2      43 ..     958     995 ..     957     997 .. 0.88

  Alignments for each domain:
  == domain 1  score: -5.4 bits;  conditional E-value: 5
         GPS   2 sCvfWdeeneetgsWsteGCe 22 
                 +Cv ++   e  ++++ + Ce
  EFC39532.1 211 KCVSYN-RCECYNGYNGSECE 230
                 599997.44446778888886 PP

  == domain 2  score: 32.8 bits;  conditional E-value: 2e-11
         GPS   2 sCvfWdeeneetgsWsteGCeltesdnknetvCsCnHLtsFA 43 
                  C +W   ne+  sW ++GCe   s+n+ +++C+CnH+t F+
  EFC39532.1 958 ACKYW---NETGQSWESNGCE-FLSSNSLNIQCQCNHTTLFS 995
                 5****...56779********.5556*************997 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   7.0   0.00017       0.6       7      29 ..      38      60 ..      30      62 .. 0.80
   2 !   13.6  13.5   1.8e-05     0.065       4      32 .]     199     229 ..     196     229 .. 0.83
   3 !   14.2   9.0   1.2e-05     0.042       6      32 .]     245     270 ..     242     270 .. 0.88
   4 !    9.8   5.0   0.00028         1       6      32 .]     284     314 ..     279     314 .. 0.73
   5 !   10.8   5.8   0.00014      0.51       7      32 .]     337     366 ..     332     366 .. 0.77
   6 ?   -2.4   0.2       1.8   6.5e+03      20      24 ..     985     989 ..     977     991 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00017
       EGF_2  7 iCgghGtCvnqcGqCdCdsgyqG 29
                +C+g+G+C ++ G+C C +  +G
  EFC39532.1 38 TCSGNGICSSSSGNCICLDLSSG 60
                7********9*******766665 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 1.8e-05
       EGF_2   4 s...deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                     d +C+ +G+Cv+  ++C+C +gy G  C
  EFC39532.1 199 KtinDGACNSNGKCVSY-NRCECYNGYNGSEC 229
                 4446899*******955.59***********9 PP

  == domain 3  score: 14.2 bits;  conditional E-value: 1.2e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C g+G C +++  C C+sg++G+ C
  EFC39532.1 245 NVCAGNGNCTSTN-YCTCKSGFYGPIC 270
                 67*******9777.5*********988 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00028
       EGF_2   6 eiCgghGtCvnqcGqCdC.....dsgyqGktC 32 
                 + C+g G+C  + G C C     + +  G++C
  EFC39532.1 284 NVCSGKGKCL-PDGTCLCydvndNVKVNGPKC 314
                 68*******9.78*****77733333336666 PP

  == domain 5  score: 10.8 bits;  conditional E-value: 0.00014
       EGF_2   7 iCgghGtC.vnqcGq....CdCdsgyqGktC 32 
                 +C+ hG+C  n++      C C  gy+G+ C
  EFC39532.1 337 ACSSHGYCsFNTT-AltggCACTEGYFGDIC 366
                 6*******65544.12444*********988 PP

  == domain 6  score: -2.4 bits;  conditional E-value: 1.8
       EGF_2  20 qCdCd 24 
                 qC+C+
  EFC39532.1 985 QCQCN 989
                 79997 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.1      0.22   7.9e+02       5      59 ..    1106    1160 ..    1102    1164 .. 0.84
   2 !   25.9   0.2   2.6e-09   9.4e-06       5      82 ..    1352    1431 ..    1348    1445 .. 0.88
   3 ?   -0.1   0.1      0.31   1.1e+03      63      85 ..    1459    1481 ..    1448    1574 .. 0.63

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.22
                  HHTSHHHHHHHHHHHHHTTCTHHHH.HHHHHHHHHTSSHHHHHHHHHHHHHHHHTS CS
         RGS    5 lledqpgrslFreFlesefseenls.FwlaveefkkakeqeelkkkakeIyneyla 59  
                  ++ ++    +F ++l + ++ e l+ F+ +   f ++ ++++  +k+ ++++ +l+
  EFC39532.1 1106 IIVNSITITAFISYLYQVTRFELLKyFYHKLAIFSNS-KEKKEGEKVLKVVKSFLS 1160
                  7778889999*********999998678899999999.888888889999999985 PP

  == domain 2  score: 25.9 bits;  conditional E-value: 2.6e-09
                  HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCS CS
         RGS    5 lledqpgrslFreFlesefseenlsFwlaveefkka..keqeelkkkakeIyneylapsspkelnidkklreelekrlek 82  
                   l+++ g+sl + F+++efs en++++   ++ + a     +elk+ ++ ++++y++++s +e+ni+++lr++l + l++
  EFC39532.1 1352 FLDSEEGCSLMEWFCKKEFSLENVQLYTYLKQNECAlnGGIKELKSFFTTLFETYIKSGSVNEVNIPSNLRKNLLSILKD 1431
                  578889********************98888777776689999******************************9988876 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.31
                  TTSSTS-HHHHHHHHHHHCSSST CS
         RGS   63 pkelnidkklreelekrlekeqp 85  
                  p+++ id+++r+ ++k+ + +++
  EFC39532.1 1459 PTSITIDNRTRKIVKKFTHVVSK 1481
                  45555555555555555443322 PP

>> RSB_motif  RNSP1-SAP18 binding (RSB) motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   9.8   0.00031       1.1      15      81 ..    1755    1818 ..    1739    1820 .. 0.65

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00031
   RSB_motif   15 ereekerkrkrsrseekarerrrerskskekrreskaskekkkeeeppakllDdlFrkTkatPciYw 81  
                  ++ +++rk+k sr+++     +++r++sk+++r+++++     + ++++ +lD lF+k k   c Y+
  EFC39532.1 1755 KKAKNQRKEKVSRRKK---SSKKNRNNSKSSKRGRSERVSIPIKKSSKKYSLDSLFKKSKNRKCRYF 1818
                  3333333333333332...2222456666677777767788888899999**********9999887 PP

>> Claudin_2  PMP-22/EMP/MP20/Claudin tight junction
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.5      0.55     2e+03      88     121 ..    1019    1049 ..     974    1091 .. 0.57
   2 ?    0.5   0.7      0.13   4.5e+02      74     142 ..    1143    1220 ..    1121    1249 .. 0.59
   3 ?   13.2   0.6   1.6e-05     0.056      86     150 ..    1267    1342 ..    1258    1356 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.55
   Claudin_2   88 larfvqvlliLslvlivlavvlgllallkqsvll 121 
                  ++++  +++i s vl+vl +v+     + +s+++
  EFC39532.1 1019 VYGS--IFFIVSCVLMVLLIVFRNYQPV-KSRFV 1049
                  3333..3466666666654444333333.33333 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.13
   Claudin_2   74 eeeivsisatsllalarfvqvlliLslvlivla...vvlgllallkqsv.......lllkaagilfllagvlgllavvv 142 
                  +e++  +++    + + +   +++Lsl+  +++   ++++ + l++++v       +++   +++++l+  l+ +++++
  EFC39532.1 1143 KEKKEGEKVLKVVKSFLSTR-IMLLSLISGFIGnlmFWTLWVILVRTNVlvgrdytYVVSISFTCIILSICLLIVGLII 1220
                  44444444433333333333.5666666666653325666677777777888888655555555555554444444443 PP

  == domain 3  score: 13.2 bits;  conditional E-value: 1.6e-05
   Claudin_2   86 lalarfvqvlliLslvlivlavvlgllallkqsv...........lllkaagilfllagvlgllavvvfiesvkkv 150 
                  + ++r+ +++++ +++++v+  ++gl++  +q++            +l +a+++f+ +g  +l+ +v    +++ +
  EFC39532.1 1267 PLYFRVEMIFFVVCFIFLVCNQIIGLSGISSQKRmivndsvsmafEILYLASYCFVFGGYSLLVLLVSKLRKSNES 1342
                  6799999********************************9999996677777999999999999998887777544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1822 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1883  (0.105025); expected 358.6 (0.02)
Passed bias filter:                      420  (0.0234257); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.13u 0.34s 00:00:01.47 Elapsed: 00:00:00.49
# Mc/sec: 11162.92
//
Query:       EFC39533.1  [L=213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.014   15.6   0.2      0.091   13.0   0.0    2.1  2  Syntaxin-18_N  SNARE-complex protein Syntaxin-18 N-terminus


Domain annotation for each model (and alignments):
>> Syntaxin-18_N  SNARE-complex protein Syntaxin-18 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.1     0.059   1.1e+03      48      72 ..     108     132 ..      88     146 .. 0.71
   2 ?   13.0   0.0   5.1e-06     0.091      29      61 ..     163     195 ..     140     205 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.059
  Syntaxin-18_N  48 AkeilkhItkLrkfLleirkaYlnv 72 
                    ++ +lk+It+ + fL+++++a +n+
     EFC39533.1 108 SRLLLKSITSNEPFLANNQSAPINI 132
                    4557888888888888888776666 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 5.1e-06
  Syntaxin-18_N  29 krkkkrlkkskekdeFikeAkeilkhItkLrkf 61 
                    ++k+ ++++ +e+ e+++ ++++lk++ +L ++
     EFC39533.1 163 SKKELEPSSLQENVEYLQHCYQLLKNVGELMDM 195
                    56777888889999****************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       584  (0.0325729); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.50
# Mc/sec: 1279.44
//
Query:       EFC39534.1  [L=1560]
Description: serine/threonine-protein kinase Nek3 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.1e-57  193.9   5.7    3.9e-39  134.6   0.0    2.9  2  Pkinase      Protein kinase domain
    3.4e-44  151.1   3.2    4.3e-28   98.3   0.0    2.5  2  Pkinase_Tyr  Protein tyrosine kinase
    0.00044   20.8   0.0       0.11   13.2   0.0    3.4  3  RCC1         Regulator of chromosome condensation (RCC1) repe


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  134.6   0.0   6.5e-43   3.9e-39       2     259 ..     983    1252 ..     982    1254 .. 0.85
   2 !   58.2   3.4   1.3e-19   7.9e-16      54     260 ..    1353    1557 ..    1347    1559 .. 0.79

  Alignments for each domain:
  == domain 1  score: 134.6 bits;  conditional E-value: 6.5e-43
                  EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS.CTTB--EEEEEEE.......SSEEEEEEE--TTEBHHHHHH CS
     Pkinase    2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk.hpnivrlyevfee.......kdelylvleyveggeladlle 90  
                    l+k+GeG+ G V+k+++++t+  vA+K+  +  +++k  k++ r + ++ k++ h+n+v++++ f e       +  l +v++++++g+l+d+l+
  EFC39534.1  983 IILKKMGEGTEGAVFKCFDRTTHSFVALKRCTEVMDQDKI-KEMNRHLDLVMKISdHKNLVTIVKKFVErkgemfnDYGLNVVMNFIPHGTLFDHLN 1078
                  5789***************************999888877.589999999999988*******998888889998667788***************9 PP

                  ....HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.TTSCBSHHH CS
     Pkinase   91 ....rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge....lKitDFGlakelessskltsfvgtseYlAPEvl.keneyskkv 178 
                      +   l   e  ++a  i +g++ lH +++i+rDlK+eNiL+d++++     Ki+DFGl ++++ +    s+ gt+  +APE + ++ +++++ 
  EFC39534.1 1079 qyrnDPNYLHYPEWLSFAIDISTGIDQLHYQNFIYRDLKSENILLDSEKNgklfCKISDFGLLTRWDPRA-SVSRKGTPLTMAPEYMdSNLKIDRSG 1174
                  775444458888999*******************************65556799**************99.8999************666677**** PP

                  HHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase  179 DvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259 
                  D++slG+++yellt +  +  + ++  +++ +++  + +  +     k+ e++ +++ +++l+ ++l+++   R+ a +++
  EFC39534.1 1175 DIFSLGCVFYELLTLERDLTINGQRFLMHEAIRN-NQAATHF--RLCKTLERNGFPPLVQRLVISMLQRKAYLRPQAYQVV 1252
                  *****************99955555555555555.2222222..234566777889*******************999987 PP

  == domain 2  score: 58.2 bits;  conditional E-value: 1.3e-19
                  HHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HH....HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE...EEE-SG CS
     Pkinase   54 klkhpnivrlyevfeekdelylvleyveggeladllerkgslsee....eakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDF 142 
                  +++h++iv+ +e f++++++y+++ +++gg+l d+ + ++  +e+     +k+ ++q++ ++ ++H+++ +H  l  eNi ++ ++ +   ++i+ +
  EFC39534.1 1353 QFHHEHIVQKVEEFTDERSFYIITTHLKGGNLLDFCKSNKLTEEKivssLLKNAMAQLCDAVVHIHERKKVHLGLCCENIRFHlSSWQsmeIMISVL 1449
                  567*********************************954444444444499*****************************87754433556****** PP

                  TTSEESSSSCS.BCTTTSCGGGS-HHHH...TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-H CS
     Pkinase  143 Glakelesssk.ltsfvgtseYlAPEvl...keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseise 235 
                  + +  +++ +k   ++     ++ PE     +++e s ++D++slG+i+y+l+t+            ++  ++++e+ + +     e+  + ++ +e
  EFC39534.1 1450 DSVMDVSELEKgIPNQLLYNVFI-PEYHcrhNDKELSFASDIFSLGLIFYQLITRDLKTT-------FR-VMTETEMNASV-----EEQLKLHSTNE 1532
                  *******9999866666666676.555556666788******************976544.......11.22221222222.....2234456779* PP

                  HHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase  236 eakdllkkllkkdpkkRltaeellq 260 
                  e+++l+ ++l+++p++R+ a+++++
  EFC39534.1 1533 ELIQLIIEMLSWEPSRRPNAKQIKS 1557
                  **********************975 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   98.3   0.0   7.2e-32   4.3e-28       4     218 ..     985    1215 ..     982    1255 .. 0.76
   2 !   51.1   2.3   1.8e-17   1.1e-13      57     259 .]    1353    1559 ..    1344    1559 .. 0.84

  Alignments for each domain:
  == domain 1  score: 98.3 bits;  conditional E-value: 7.2e-32
                   EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEESSSS.......EEEEEE--TTEBHHHH CS
  Pkinase_Tyr    4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkkl.khpnivkllgvctkeep.......llivteyvkgGdLlkf 91  
                    kk+GeG+ G V+++  +    +++  Va+K ++e +++++ +e+ + +++ +k+ +h+n+v ++   ++++        l +v++++++G+L ++
   EFC39534.1  985 LKKMGEGTEGAVFKCFDR----TTHSFVALKRCTEVMDQDKIKEMNRHLDLVMKIsDHKNLVTIVKKFVERKGemfndygLNVVMNFIPHGTLFDH 1076
                   689************988....88999************************99999********999884433357777799************** PP

                   HHHT..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE CS
  Pkinase_Tyr   92 Lrkk..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk 181 
                   L++   + + l++ + lsfa++++ G++ L+ ++++ rdl + N+Ll++    + ++kisDfGL  +   d +   + ++k     mapE ++++ 
   EFC39534.1 1077 LNQYrnDPNYLHYPEWLSFAIDISTGIDQLHYQNFIYRDLKSENILLDSekngKLFCKISDFGLLTRW--DPRA--SVSRKGTPLTMAPEYMDSNL 1168
                   *986336788999***********************************96666679**********99..3332..23333333459*****9876 PP

                   .EEHHHHHHHHHHHHHHHHTTSSGT.........TTTSHHHHHHHHH CS
  Pkinase_Tyr  182 .ftsksDvWsfGvllwEiftlgesp.........ypglkneevlekl 218 
                    +  + D++s G + +E++tl ++          ++ ++n+++++++
   EFC39534.1 1169 kIDRSGDIFSLGCVFYELLTLERDLtingqrflmHEAIRNNQAATHF 1215
                   499999**************877663444444433333344433333 PP

  == domain 2  score: 51.1 bits;  conditional E-value: 1.8e-17
                   TS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHT..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEE..ETTEEEE-STT CS
  Pkinase_Tyr   57 klkhpnivkllgvctkeepllivteyvkgGdLlkfLrkk..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLls..enkvvkisDfG 148 
                   +++h++iv+ +   t+e++ +i+t  +kgG+Ll+f +++  ++ek+  + l + ++q+++++ +++++k vH  l++ N+  +  + + + i    
   EFC39534.1 1353 QFHHEHIVQKVEEFTDERSFYIITTHLKGGNLLDFCKSNklTEEKIVSSLLKNAMAQLCDAVVHIHERKKVHLGLCCENIRFHlsSWQSMEIMISV 1448
                   67***********************************9965677777788888999************************7552155566666444 PP

                   THEETTTSSEEEETTSSTSGGGGS-HHHH...HHSEEEHHHHHHHHHHHHHHHHTTS.SGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHH CS
  Pkinase_Tyr  149 LardiekddeyvkkeeaklpvkWmapEsl...kekkftsksDvWsfGvllwEiftlg.espypglkneevleklkegkrlekpekcpeelyelmkk 240 
                   L +++++ +e +k   ++l ++   pE     ++k+++ +sD++s G + + ++t   +++++ ++++e+ + ++e+ +l+  +   eel +l+ +
   EFC39534.1 1449 L-DSVMDVSELEKGIPNQLLYNVFIPEYHcrhNDKELSFASDIFSLGLIFYQLITRDlKTTFRVMTETEMNASVEEQLKLHSTN---EELIQLIIE 1540
                   4.4555889999999999999999999752225667****************99976256778889999999999999987765...9******** PP

                   HT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  241 cweedpeeRptfselvekl 259 
                    ++ +p++Rp+ +++ ++l
   EFC39534.1 1541 MLSWEPSRRPNAKQIKSRL 1559
                   **************99876 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.2   0.0   1.8e-05      0.11       3      41 ..     244     284 ..     242     293 .. 0.76
   2 ?   -1.8   0.0      0.82   4.9e+03      32      45 ..     386     399 ..     380     399 .. 0.75
   3 ?    3.2   0.0     0.024   1.4e+02       4      42 ..     414     454 ..     413     457 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.8e-05
                 EEEEEE--GGGTTSSSS-..--EEEEEE-.GGGTTS-EEEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt..esvlvPtkv.eglsgnrvvkva 41 
                 +++  G+nd+++LGlg++   +v vP+++  ++++++v k++
  EFC39534.1 244 HIWVAGCNDDYRLGLGHNmpLTV-VPSLLrYNFKNRKVRKIC 284
                 57889*************75333.699994345555888876 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.82
                 GTTS-EEEEEEETT CS
        RCC1  32 lsgnrvvkvacGdd 45 
                 l g++++k++c dd
  EFC39534.1 386 LFGKEIIKISCSDD 399
                 44569******986 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.024
                 EEEEE--GGGTTSSSS---EEEEEE-GGGTTS..-EEEEEE CS
        RCC1   4 VysWGrndyGqLGlgttesvlvPtkveglsgn..rvvkvac 42 
                 +++ G+n  G  G g   + + P++++++++n  ++ +  c
  EFC39534.1 414 IWGLGNNMSGIFGVGLARTFNGPKEITFFKENgiEIEDLKC 454
                 7999**********99988889********99888877776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1560 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       856  (0.0477439); expected 358.6 (0.02)
Passed bias filter:                      423  (0.0235931); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.96u 0.31s 00:00:01.27 Elapsed: 00:00:00.52
# Mc/sec: 9074.93
//
Query:       EFC39535.1  [L=691]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.2e-21   74.6   5.0    7.2e-21   74.6   5.0    2.3  2  CBFB_NFYA        CCAAT-binding transcription factor (CBF-B/NF


Domain annotation for each model (and alignments):
>> CBFB_NFYA  CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   74.6   5.0     4e-25   7.2e-21       2      56 .]     382     438 ..     381     438 .. 0.93
   2 ?   -1.3   0.5      0.19   3.4e+03      31      50 ..     613     632 ..     590     636 .. 0.71

  Alignments for each domain:
  == domain 1  score: 74.6 bits;  conditional E-value: 4e-25
   CBFB_NFYA   2 plyVNakQynrIlkRReaRakleaelkl..rkarkkylheSRhkhAmrRpRgpgGRF 56 
                 ++yVN+kQy+rIlkRR aRakle+++k   + + k y+++SRh++A +R RgpgGRF
  EFC39535.1 382 TIYVNPKQYQRILKRRVARAKLEQQMKNagQYKDKSYKYNSRHEWAKKRARGPGGRF 438
                 69**********************9998755666**********************9 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.19
   CBFB_NFYA  31 karkkylheSRhkhAmrRpR 50 
                   +kk+   SR+ h    pR
  EFC39535.1 613 LVHKKFSTLSRQSHHATTPR 632
                 344999999**999555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (691 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1412  (0.0787551); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.79u 0.31s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 4024.70
//
Query:       EFC39536.1  [L=328]
Description: hypothetical protein NAEGRDRAFT_72718 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      9e-19   67.5  32.6    4.5e-10   39.7  12.6    2.5  2  zf-RING_2      Ring finger domain
    7.7e-15   54.6  33.8    9.5e-08   31.9  14.3    2.5  2  zf-RING_5      zinc-RING finger domain
    6.4e-13   48.5  25.0    5.8e-07   29.4   6.1    3.5  3  zf-RING_UBOX   RING-type zinc-finger
      5e-11   42.1  25.0    1.5e-05   24.7  10.0    2.8  2  zf-RING_11     RING-like zinc finger
    1.3e-10   41.1  14.8    8.5e-07   28.9   3.7    2.5  2  zf-ANAPC11     Anaphase-promoting complex subunit 11 RING-H2 
      1e-09   38.1  27.5    5.6e-05   22.9  10.8    2.5  2  zf-C3HC4_3     Zinc finger, C3HC4 type (RING finger)
    1.4e-09   38.1  27.3    6.1e-05   23.2  10.2    2.9  2  zf-rbx1        RING-H2 zinc finger domain
    2.3e-09   36.9  31.1    7.7e-05   22.5  12.5    2.7  2  zf-C3HC4_2     Zinc finger, C3HC4 type (RING finger)
    1.2e-08   34.7  35.0    3.1e-05   23.7  14.3    2.6  2  zf-C3HC4       Zinc finger, C3HC4 type (RING finger)
    0.00021   21.2   9.8    0.00021   21.2   9.8    3.9  3  Prok-RING_1    Prokaryotic RING finger family 1
     0.0003   20.6  34.3      0.037   13.9  14.5    4.2  4  Prok-RING_4    Prokaryotic RING finger family 4
    0.00036   20.1  25.7    0.00084   18.9   8.0    2.8  3  Zn_ribbon_17   Zinc-ribbon, C4HC2 type
  ------ inclusion threshold ------
      0.011   15.9  30.3      0.068   13.3   9.9    3.2  3  zf-C3HC4_4     zinc finger of C3HC4-type, RING
      0.024   14.4   1.1      0.037   13.8   0.0    1.9  2  IQ             IQ calmodulin-binding motif
       0.04   14.2  11.2       0.04   14.2  11.2    3.2  3  zf-RING-like   RING-like domain
       0.16   12.4   1.1       0.85   10.1   0.2    2.2  2  DUF2779        Domain of unknown function(DUF2779)
       0.39   10.9  26.4      0.064   13.4   4.6    3.5  4  Zf_RING        KIAA1045 RING finger
        4.4    7.3  27.4       0.43   10.5   9.4    2.9  2  PHD            PHD-finger
        5.7    7.2  29.7        4.2    7.6  10.2    3.4  3  FANCL_C        FANCL C-terminal domain


Domain annotation for each model (and alignments):
>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.5  12.0   4.1e-11   3.9e-08       3      44 .]     110     155 ..     108     155 .. 0.83
   2 !   39.7  12.6   4.7e-13   4.5e-10       2      44 .]     271     316 ..     270     316 .. 0.84

  Alignments for each domain:
  == domain 1  score: 33.5 bits;  conditional E-value: 4.1e-11
   zf-RING_2   3 CpICleelssadsvlllpCgHvfhreClerwlrssst.....CPlCr 44 
                 CpIC+e++  +d v+++ CgHv+h++Cl+ + ++++      CP+Cr
  EFC39536.1 110 CPICFESFAFNDIVCITNCGHVYHQNCLQSF-ERCNIwrkrsCPMCR 155
                 ****************************774.4443345557****9 PP

  == domain 2  score: 39.7 bits;  conditional E-value: 4.7e-13
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreCl...erwlrssst.CPlCr 44 
                 eCpICl++++  ++++++ CgH+fh++Cl   e++++s+++ CP+Cr
  EFC39536.1 271 ECPICLCAFKG-RKCTITSCGHIFHEKCLssfEKFIESKNQkCPVCR 316
                 9********75.6666566*********96666779999999****9 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4  11.5   1.3e-09   1.2e-06       2      43 ..     110     155 ..     109     156 .. 0.98
   2 !   31.9  14.3     1e-10   9.5e-08       1      44 []     271     317 ..     271     317 .. 0.98

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 1.3e-09
   zf-RING_5   2 CnkCfeklskeekfyltsCgHifCekClkkll....ekeavCpiCr 43 
                 C++Cfe++  ++ +++t+CgH+++++Cl+        +++ Cp+Cr
  EFC39536.1 110 CPICFESFAFNDIVCITNCGHVYHQNCLQSFErcniWRKRSCPMCR 155
                 **********************************9*9********8 PP

  == domain 2  score: 31.9 bits;  conditional E-value: 1e-10
   zf-RING_5   1 hCnkCfeklskeekfyltsCgHifCekClkkll....ekeavCpiCrk 44 
                 +C++C + + k +k+ +tsCgHif+ekCl+        k+++Cp+Cr+
  EFC39536.1 271 ECPICLCAF-KGRKCTITSCGHIFHEKCLSSFEkfieSKNQKCPVCRQ 317
                 6********.************************************97 PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.4   6.1   6.2e-10   5.8e-07       1      39 []     110     152 ..     110     152 .. 0.82
   2 !   25.7   6.9   8.9e-09   8.4e-06       1      39 []     272     313 ..     272     313 .. 0.82
   3 ?    3.6   0.2     0.072        68       1       9 [.     312     320 ..     312     325 .. 0.81

  Alignments for each domain:
  == domain 1  score: 29.4 bits;  conditional E-value: 6.2e-10
  zf-RING_UBOX   1 CpIClelft..dPlv..lpCGHtFCreClw.elskslegafkCP 39 
                   CpIC+e+f   d  v  ++CGH+++++Cl+  ++ +  ++++CP
    EFC39536.1 110 CPICFESFAfnDI-VciTNCGHVYHQNCLQsFERCNIWRKRSCP 152
                   ******9976555.55359**********778888888899998 PP

  == domain 2  score: 25.7 bits;  conditional E-value: 8.9e-09
  zf-RING_UBOX   1 CpIClelft...dPlvlpCGHtFCreClw.elskslegafkCP 39 
                   CpICl  f+     ++++CGH+F+++Cl   +++ ++++ kCP
    EFC39536.1 272 CPICLCAFKgrkC-TITSCGHIFHEKCLSsFEKFIESKNQKCP 313
                   *********6431.4569**********557788888888888 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.072
  zf-RING_UBOX   1 CpIClelft 9  
                   Cp+C++ + 
    EFC39536.1 312 CPVCRQIYV 320
                   ******985 PP

>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   7.0   7.1e-08   6.7e-05       2      29 .]     110     137 ..     109     137 .. 0.97
   2 !   24.7  10.0   1.5e-08   1.5e-05       1      29 []     271     298 ..     271     298 .. 0.86

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 7.1e-08
  zf-RING_11   2 CsICLeefkpgqalfilpCsHtFHfkCI 29 
                 C IC e+f+ ++ + i+ C+H++H++C+
  EFC39536.1 110 CPICFESFAFNDIVCITNCGHVYHQNCL 137
                 ***************************6 PP

  == domain 2  score: 24.7 bits;  conditional E-value: 1.5e-08
  zf-RING_11   1 eCsICLeefkpgqalfilpCsHtFHfkCI 29 
                 eC ICL  fk  ++  i++C+H+FH kC+
  EFC39536.1 271 ECPICLCAFKGRKCT-ITSCGHIFHEKCL 298
                 9********765555.66**********6 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   3.4   3.5e-06    0.0033      31      80 ..     106     157 ..      84     163 .. 0.73
   2 !   28.9   3.7     9e-10   8.5e-07      26      82 ..     263     320 ..     247     323 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 3.5e-06
                 TTS--TTCSTTTTTS.-EEEBTTS-EEEHHHHHHHHHHHS.TSSB-TTTSSB CS
  zf-ANAPC11  31 fdGtcpsckfpGddc.plvlGkckhnfhlhcilkwletet.skglcpmcrqt 80 
                  +  cp c         + + +c h++h+ c++ +   +   k  cpmcr +
  EFC39536.1 106 LEDGCPICFESFAFNdIVCITNCGHVYHQNCLQSFERCNIwRKRSCPMCRLE 157
                 5677999965544440455789************99987626789*****64 PP

  == domain 2  score: 28.9 bits;  conditional E-value: 9e-10
                 TT-SBTTS--TT..CSTTTTTS-EEEBTTS-EEEHHHHHHHHHHHSTS.SB-TTTSSB-- CS
  zf-ANAPC11  26 icrvsfdGtcps..ckfpGddcplvlGkckhnfhlhcilkwletetsk.glcpmcrqtfk 82 
                 + r + d  cp   c f G +c++   +c h+fh++c+  + +  +sk ++cp+crq+++
  EFC39536.1 263 LGREEKDEECPIclCAFKGRKCTI--TSCGHIFHEKCLSSFEKFIESKnQKCPVCRQIYV 320
                 557777888997225788999986..69***********998876665278******986 PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   8.7     3e-07   0.00028       3      44 ..     108     155 ..     106     159 .. 0.85
   2 !   22.9  10.8   5.9e-08   5.6e-05       2      46 ..     269     318 ..     268     322 .. 0.90

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 3e-07
                 SB-TTTSSS..BS-.EEETTEEEEEE-HHHHHHHHH....TT-B-TTT- CS
  zf-C3HC4_3   3 eeCviCler..prn.vvllpCgHlvlCeeCaekllk....rkkkCpiCr 44 
                 + C+iC+e+    + v++ +CgH+ + ++C++++++    rk++Cp+Cr
  EFC39536.1 108 DGCPICFESfaFNDiVCITNCGHV-YHQNCLQSFERcniwRKRSCPMCR 155
                 56******766555256668****.99*******99************9 PP

  == domain 2  score: 22.9 bits;  conditional E-value: 5.9e-08
                 GSB-TTTSS..SBS-EEETTEEEEEE-HHHHHHHHH....TT-B-TTT--B CS
  zf-C3HC4_3   2 deeCviCle..rprnvvllpCgHlvlCeeCaekllk....rkkkCpiCrrp 46 
                 deeC+iCl   + r++++  CgH+ + e+C+++++k    +++kCp+Cr+ 
  EFC39536.1 269 DEECPICLCafKGRKCTITSCGHI-FHEKCLSSFEKfiesKNQKCPVCRQI 318
                 789*****9445999*********.*********99**9**********95 PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   9.1   7.3e-07   0.00069       9      55 .]     105     155 ..     102     155 .. 0.86
   2 !   23.2  10.2   6.4e-08   6.1e-05       7      55 .]     265     316 ..     259     316 .. 0.78

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 7.3e-07
     zf-rbx1   9 eleeacieckapgdeecpvvlGeCgHaFHlhCiskWlkt....rkvCPlcr 55 
                 +le+ c+ c ++   +  v + +CgH++H++C+++  +     +++CP+cr
  EFC39536.1 105 HLEDGCPICFESFAFNDIVCITNCGHVYHQNCLQSFERCniwrKRSCPMCR 155
                 7888899988887776567778*************99999998999****8 PP

  == domain 2  score: 23.2 bits;  conditional E-value: 6.4e-08
     zf-rbx1   7 rneleeaciec..kapgdeecpvvlGeCgHaFHlhCiskWlkt....rkvCPlcr 55 
                 r+e +e+c+ c   ++g++ c+++   CgH FH +C+s+  k     +++CP+cr
  EFC39536.1 265 REEKDEECPIClcAFKGRK-CTITS--CGHIFHEKCLSSFEKFieskNQKCPVCR 316
                 6777888887522677777.99887..**********9876666668999****8 PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8  10.6   5.6e-07   0.00053       2      40 .]     110     154 ..     109     154 .. 0.79
   2 !   22.5  12.5   8.1e-08   7.7e-05       1      40 []     271     315 ..     271     315 .. 0.82

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 5.6e-07
  zf-C3HC4_2   2 CpiCldml..kdpsvvtpCgHvfCqkCilr....sLeekneCPlC 40 
                 CpiC++++  +d + +t+CgHv++q+C++      + +k +CP+C
  EFC39536.1 110 CPICFESFafNDIVCITNCGHVYHQNCLQSfercNIWRKRSCPMC 154
                 ******86327889999**********98622244557789***9 PP

  == domain 2  score: 22.5 bits;  conditional E-value: 8.1e-08
  zf-C3HC4_2   1 kCpiCldmlkdp.svvtpCgHvfCqkCi...lrsLeekn.eCPlC 40 
                 +CpiCl  +k    ++t CgH f++kC+    + +e+kn +CP+C
  EFC39536.1 271 ECPICLCAFKGRkCTITSCGHIFHEKCLssfEKFIESKNqKCPVC 315
                 6********95415778**********7222568999999***** PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4  12.7   6.4e-06    0.0061       1      41 []     110     154 ..     110     154 .. 0.88
   2 !   23.7  14.3   3.3e-08   3.1e-05       1      41 []     272     315 ..     272     315 .. 0.96

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 6.4e-06
                 -TTT-S--SS-E...E-TTS--B-CHHHHHHHHC..TSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepn..elleCkHsfCskCirkilks..rkkvkCPlC 41 
                 CpiC+e ++ ++   +++C+H ++++C+++  +    +k++CP+C
  EFC39536.1 110 CPICFESFAFNDivCITNCGHVYHQNCLQSFERCniWRKRSCPMC 154
                 ******998777669*************9988877777888**** PP

  == domain 2  score: 23.7 bits;  conditional E-value: 3.3e-08
                 -TTT-S--SS-E..E-TTS--B-CHHHHHHHHC..TSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepn.elleCkHsfCskCirkilks..rkkvkCPlC 41 
                 CpiCl+ +k  + +++ C+H f++kC+++  k+  +k++kCP+C
  EFC39536.1 272 CPICLCAFKGRKcTITSCGHIFHEKCLSSFEKFieSKNQKCPVC 315
                 *********9888****************999999********* PP

>> Prok-RING_1  Prokaryotic RING finger family 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   9.8   2.2e-07   0.00021       4      42 ..     107     144 ..     104     155 .. 0.87
   2 ?    4.0   6.4     0.051        48       3      40 ..     268     303 ..     266     309 .. 0.81
   3 ?    4.9   0.6     0.027        26       3      12 ..     308     317 ..     306     322 .. 0.83

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 2.2e-07
  Prok-RING_1   4 gkkCpvCgkelkeedDiVvCpeCgtpyHraCyekagkCv 42 
                  ++ Cp+C + ++ + DiV  ++Cg +yH++C + +++C 
   EFC39536.1 107 EDGCPICFESFAFN-DIVCITNCGHVYHQNCLQSFERCN 144
                  578********998.***********************5 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.051
  Prok-RING_1   3 tgkkCpvCgkelkeedDiVvCpeCgtpyHraCyekagk 40 
                  ++++Cp+C  ++k  +   + + Cg  +H +C + ++k
   EFC39536.1 268 KDEECPICLCAFKGRK--CTITSCGHIFHEKCLSSFEK 303
                  6789*********994..34479*********998776 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.027
  Prok-RING_1   3 tgkkCpvCgk 12 
                  +++kCpvC++
   EFC39536.1 308 KNQKCPVCRQ 317
                  79******98 PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.3     0.089        84      32      39 ..     109     116 ..     101     123 .. 0.75
   2 ?    4.8  13.7     0.028        26       1      38 [.     110     156 ..     110     162 .. 0.82
   3 ?    1.8   1.0      0.24   2.3e+02      29      37 ..     268     276 ..     264     281 .. 0.75
   4 !   13.9  14.5   3.9e-05     0.037       3      39 ..     276     318 ..     272     324 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.089
  Prok-RING_4  32 sCPlCqrr 39 
                  +CP+C + 
   EFC39536.1 109 GCPICFES 116
                  8****765 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.028
  Prok-RING_4   1 CvlCgeq...ekkailepCgHlvCkeCfdskdls......sCPlCqr 38 
                  C +C e+   +  + +  CgH+  ++C++s +        sCP+C+ 
   EFC39536.1 110 CPICFESfafNDIVCITNCGHVYHQNCLQSFERCniwrkrSCPMCRL 156
                  7788887777778899************998544477888*****95 PP

  == domain 3  score: 1.8 bits;  conditional E-value: 0.24
  Prok-RING_4  29 dlssCPlCq 37 
                  + + CP+C 
   EFC39536.1 268 KDEECPICL 276
                  5568****5 PP

  == domain 4  score: 13.9 bits;  conditional E-value: 3.9e-05
  Prok-RING_4   3 lCgeqekkailepCgHlvCkeCfdsk......dlssCPlCqrr 39 
                  lC+ +++k  + +CgH++ ++C++s       +++ CP+C++ 
   EFC39536.1 276 LCAFKGRKCTITSCGHIFHEKCLSSFekfiesKNQKCPVCRQI 318
                  79999*****************9987544443555******86 PP

>> Zn_ribbon_17  Zinc-ribbon, C4HC2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   9.8    0.0095         9       7      36 ..     110     140 ..     104     155 .. 0.69
   2 ?   -1.8   0.1       2.7   2.5e+03       4      12 ..     148     156 ..     145     158 .. 0.79
   3 !   18.9   8.0   8.9e-07   0.00084       4      47 ..     269     314 ..     266     316 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0095
  Zn_ribbon_17   7 CayCelavkgrvvlc.gvCeHvlHasCarew 36 
                   C +C  +   + ++c ++C+Hv H++C+++ 
    EFC39536.1 110 CPICFESFAFNDIVCiTNCGHVYHQNCLQSF 140
                   777777666666666479*********9874 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2.7
  Zn_ribbon_17   4 lksCayCel 12 
                   ++sC +C l
    EFC39536.1 148 KRSCPMCRL 156
                   678999987 PP

  == domain 3  score: 18.9 bits;  conditional E-value: 8.9e-07
  Zn_ribbon_17   4 lksCayCelavkgrvvlcgvCeHvlHasCarew..fenddlaeCps 47 
                    ++C +C  a kgr +  ++C+H+ H+ C+++   f + + ++Cp+
    EFC39536.1 269 DEECPICLCAFKGRKCTITSCGHIFHEKCLSSFekFIESKNQKCPV 314
                   679***************************9866677777799997 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4  12.0    0.0053         5       1      42 []     110     154 ..     110     154 .. 0.86
   2 ?   13.3   9.9   7.2e-05     0.068       1      42 []     272     315 ..     272     315 .. 0.91
   3 ?    5.0   0.5      0.03        28       1      13 [.     312     325 ..     312     326 .. 0.90

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0053
  zf-C3HC4_4   1 CPiCldY..LekPvsl.eCGhsfClsCisslqkepdgeqllCplC 42 
                 CPiC +   +++ v + +CGh++ ++C++s+   +   + +Cp+C
  EFC39536.1 110 CPICFESfaFNDIVCItNCGHVYHQNCLQSFERCNIWRKRSCPMC 154
                 ****98623567787769**************99999999****9 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 7.2e-05
  zf-C3HC4_4   1 CPiCldYLe..kPvsleCGhsfClsCisslqkepdgeqllCplC 42 
                 CPiCl  ++  k +  +CGh+f  +C+ss+ k  ++++  Cp+C
  EFC39536.1 272 CPICLCAFKgrKCTITSCGHIFHEKCLSSFEKFIESKNQKCPVC 315
                 ****9999644677889*************************** PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.03
  zf-C3HC4_4   1 CPiCld.YLekPvs 13 
                 CP+C++ Y +kP+s
  EFC39536.1 312 CPVCRQiYVKKPIS 325
                 ****98799***98 PP

>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.2       7.6   7.2e+03       7      19 ..     137     149 ..     136     149 .. 0.73
   2 ?   13.8   0.0   3.9e-05     0.037       3      21 .]     175     193 ..     173     193 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 7.6
                 HHHHHHHHHHHHH CS
          IQ   7 IQaawRGylaRkr 19 
                 +Q++ R    Rkr
  EFC39536.1 137 LQSFERCNIWRKR 149
                 7888788888886 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 3.9e-05
                 HHHHHHHHHHHHHHHHHHH CS
          IQ   3 aaikIQaawRGylaRkryk 21 
                 +a+  Q+ +RG ++Rk y+
  EFC39536.1 175 CALMVQSLCRGNVMRKIYR 193
                 7999************997 PP

>> zf-RING-like  RING-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9  11.4     0.074        70       1      43 []     110     154 ..     110     154 .. 0.78
   2 ?   -0.6   0.2       1.8   1.7e+03      33      43 .]     265     275 ..     261     275 .. 0.80
   3 ?   14.2  11.2   4.3e-05      0.04       8      43 .]     278     315 ..     272     315 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.074
  zf-RING-like   1 CeaC.keivtqGvrCsnesCnvrlHvdCfqhyirthss..kkCpkC 43 
                   C +C ++ ++  + C  ++C   +H++C+q + r +    ++Cp C
    EFC39536.1 110 CPICfESFAFNDIVCI-TNCGHVYHQNCLQSFERCNIWrkRSCPMC 154
                   66663346788999*8.9*************98764333389**99 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 1.8
  zf-RING-like  33 rthsskkCpkC 43 
                   r++++++Cp C
    EFC39536.1 265 REEKDEECPIC 275
                   5677899**99 PP

  == domain 3  score: 14.2 bits;  conditional E-value: 4.3e-05
  zf-RING-like   8 vtqGvrCsnesCnvrlHvdC...fqhyirthsskkCpkC 43 
                   +++G +C+ +sC  ++H++C   f+++i +++++kCp C
    EFC39536.1 278 AFKGRKCTITSCGHIFHEKClssFEKFI-ESKNQKCPVC 315
                   789*****************44445677.78889***** PP

>> DUF2779  Domain of unknown function(DUF2779)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.1      0.76   7.2e+02      11      71 ..      26      55 ..       9     140 .. 0.64
   2 ?   10.1   0.2    0.0009      0.85      37     112 ..     163     238 ..     144     253 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.76
     DUF2779 11 alPpfdgtkpYqqipfqfSlhilqeegevehkeflaespntdpreelieeLikiiekegsv 71
                  P+ +++k ++ ++fq                                e++++++++g +
  EFC39536.1 26 NKPYLQNEKLWTAVAFQQ-------------------------------EFTESLNNHGLL 55
                334455555555555554...............................444444443332 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.0009
     DUF2779  37 gevehkeflaespntdpreelieeLikiiekegsvvvynksfEksrlkelaqlfpeykeelkqiienlvDlldlfk 112
                 +++ h + l++      ++ +  + ++ i+++  +  y + +Ek ++++l ++ ++++ ++ q  +n+ D l+ + 
  EFC39536.1 163 ETKLHLSLLKNTCALMVQSLCRGNVMRKIYRRLYFAKYPDRHEKYCVSKLSSINERLESRVIQDEKNVDDFLKRID 238
                 4456777777777777888899999**************************9999999999998888888777655 PP

>> Zf_RING  KIAA1045 RING finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   4.6   6.8e-05     0.064       5      41 ..     107     144 ..     104     150 .. 0.90
   2 ?   -2.6   0.0       6.5   6.1e+03      31      49 ..     206     224 ..     203     229 .. 0.71
   3 ?    7.8   6.5    0.0036       3.4       3      41 ..     267     305 ..     265     312 .. 0.81
   4 ?    0.3   0.1      0.82   7.7e+02      17      30 ..     307     320 ..     299     324 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 6.8e-05
     Zf_RING   5 delCeiC.evytaeelypCRvCtkvfHegClrklgylq 41 
                 ++ C iC e ++ ++++    C +v+H++Cl++++ ++
  EFC39536.1 107 EDGCPICfESFAFNDIVCITNCGHVYHQNCLQSFERCN 144
                 567****999**999999999***********998876 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 6.5
     Zf_RING  31 egClrklgylqdesalell 49 
                 + C+ kl  ++++  + ++
  EFC39536.1 206 KYCVSKLSSINERLESRVI 224
                 4699999988877666655 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0036
     Zf_RING   3 eedelCeiCevytaeelypCRvCtkvfHegClrklgylq 41 
                 e+de C iC       +     C ++fHe+Cl ++++  
  EFC39536.1 267 EKDEECPICLCAFKGRKCTITSCGHIFHEKCLSSFEKFI 305
                 689******8877777778888**********9987665 PP

  == domain 4  score: 0.3 bits;  conditional E-value: 0.82
     Zf_RING  17 eelypCRvCtkvfH 30 
                 ++  +C vC +++ 
  EFC39536.1 307 SKNQKCPVCRQIYV 320
                 56678999998885 PP

>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   9.4   0.00045      0.43       2      50 ..     110     155 ..     109     157 .. 0.82
   2 ?    1.8   9.9      0.24   2.3e+02      19      50 ..     287     316 ..     269     318 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00045
                 BTTTTSTTSTTSCEEEETTTSCEEETTTSSSTHSHHSHHSSTBSSTTTH CS
         PHD   2 CavCkkksdeeeelvqCdgCkrwfHqkClkppleseekpegewlCekCk 50 
                 C +C + s + +++v+  +C++ +Hq+Cl+  ++ +    ++  C+ C+
  EFC39536.1 110 CPICFE-SFAFNDIVCITNCGHVYHQNCLQSFERCNIW--RKRSCPMCR 155
                 9*****.999*****99************988773333..346788886 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.24
                 TTTSCEEETTTSSSTHSHHSHHSSTBSSTTTH CS
         PHD  19 dgCkrwfHqkClkppleseekpegewlCekCk 50 
                  +C++ fH kCl+  ++  e +  +  C+ C+
  EFC39536.1 287 TSCGHIFHEKCLSSFEKFIESK--NQKCPVCR 316
                 58**********9998855544..57899997 PP

>> FANCL_C  FANCL C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   9.2      0.02        19       3      42 ..     108     142 ..     106     157 .. 0.81
   2 ?   -1.4   1.0       2.9   2.7e+03       4      36 ..     150     183 ..     142     197 .. 0.62
   3 ?    7.6  10.2    0.0044       4.2       3      60 ..     270     314 ..     268     325 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.02
                 -S-SSS--SS-TT-----B--S-TT----B-SGGGHHHHH CS
     FANCL_C   3 veCgiCyayrldsgevpdisCdnekCnkkfHsaCLkeWlr 42 
                   C+iC+  +       di+C  ++C++ +H++CL+ + r
  EFC39536.1 108 DGCPICFESFA----FNDIVCI-TNCGHVYHQNCLQSFER 142
                 57*****9988....8899996.68**********97655 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.9
                 S-SSS--SS-.TT-----B--S-TT----B-SGG CS
     FANCL_C   4 eCgiCyayrl.dsgevpdisCdnekCnkkfHsaC 36 
                 +C++C  +   ++++  + s   + C++ + s C
  EFC39536.1 150 SCPMCRLEDYqRKETKLHLSLLKNTCALMVQSLC 183
                 5777765554133344445555666666666666 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0044
                 -S-SSS--SS-TT-----B--S-TT----B-SGGGHHHHHHHHSSS-TTT--EEE-TT CS
     FANCL_C   3 veCgiCyayrldsgevpdisCdnekCnkkfHsaCLkeWlrslkesrqsfdvlfGeCPy 60 
                  eC+iC++ +          C  ++C+++fH++CL  + + +++  q       +CP 
  EFC39536.1 270 EECPICLCAFK------GRKCTITSCGHIFHEKCLSSFEKFIESKNQ-------KCPV 314
                 69******999......456888899*********986555555544.......4444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (328 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1324  (0.0738468); expected 358.6 (0.02)
Passed bias filter:                      565  (0.0315132); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.59u 0.26s 00:00:00.85 Elapsed: 00:00:00.48
# Mc/sec: 2052.57
//
Query:       EFC39537.1  [L=350]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.063   14.0   0.2        0.2   12.5   0.2    1.8  1  TraD_N    F sex factor protein N terminal


Domain annotation for each model (and alignments):
>> TraD_N  F sex factor protein N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.2   1.1e-05       0.2      12      77 ..      92     156 ..      88     166 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 1.1e-05
      TraD_N  12 glllwlrlsqevflnglyYwaieeyvslknligsaafydiktikitlasllakkwihlaaeqllek 77 
                 + l++l l    fl +++Yw  e+ + + ++i+s  f d k  k tl+    ++ ++l+++ ll++
  EFC39537.1  92 SNLFVLCLMVSSFLLVFWYWDKERDGVFFQIINS-EFLDEKIWKETLENGQSQPFVKLNGKILLKN 156
                 567888888899**********************.9999999******************999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (350 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       589  (0.0328518); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.37s 00:00:00.97 Elapsed: 00:00:00.57
# Mc/sec: 1843.25
//
Query:       EFC39538.1  [L=1776]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
          0 1114.5 114.0    1.7e-15   56.4   0.0   36.7 40  DUF4116          Domain of unknown function (DUF4116)
    2.3e-06   27.6   0.1        2.8    8.1   0.0    7.5 10  DUF1667          Protein of unknown function (DUF1667)
  ------ inclusion threshold ------
      0.074   13.2   4.0    1.2e+02    2.8   0.0    6.2  6  DUF4853          Domain of unknown function (DUF4853)
       0.15   12.0   0.0       0.91    9.6   0.0    2.4  1  CholecysA-Rec_N  Cholecystokinin A receptor, N-terminal
       0.48   10.0  16.8       0.52    9.9   0.1    6.4  6  IL6              Interleukin-6/G-CSF/MGF family


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.4   0.9   1.1e-14   4.1e-11       5      49 .]      92     136 ..      88     136 .. 0.95
   2 !   50.9   0.1   2.7e-17   9.6e-14       1      49 []     138     186 ..     138     186 .. 0.99
   3 !   40.9   0.0   3.4e-14   1.2e-10       1      49 []     188     238 ..     188     238 .. 0.95
   4 !   22.3   0.0   2.2e-08   7.8e-05      13      49 .]     261     297 ..     240     297 .. 0.75
   5 !   47.9   0.1   2.2e-16     8e-13       1      49 []     299     347 ..     299     347 .. 0.99
   6 !   35.6   0.1   1.5e-12   5.5e-09      18      49 .]     341     372 ..     338     372 .. 0.97
   7 !   53.3   0.3   4.6e-18   1.7e-14       1      49 []     349     397 ..     349     397 .. 0.99
   8 !   51.5   0.3   1.7e-17   6.1e-14       1      49 []     374     422 ..     374     422 .. 0.98
   9 !   52.4   0.6   8.8e-18   3.2e-14       1      49 []     399     447 ..     399     447 .. 0.99
  10 !   54.2   0.1   2.4e-18   8.7e-15       1      49 []     424     472 ..     424     472 .. 0.97
  11 !   56.4   0.0   4.8e-19   1.7e-15       1      49 []     449     497 ..     449     497 .. 0.98
  12 !   36.8   0.8   6.5e-13   2.3e-09       1      38 [.     499     536 ..     499     539 .. 0.94
  13 !   40.5   0.1   4.5e-14   1.6e-10      10      49 .]     539     578 ..     534     578 .. 0.92
  14 !   54.6   0.0   1.8e-18   6.6e-15       1      49 []     580     628 ..     580     628 .. 0.99
  15 !   32.3   0.0   1.7e-11     6e-08       1      46 [.     630     675 ..     630     676 .. 0.98
  16 !   21.1   0.0   5.4e-08   0.00019      12      45 ..     691     724 ..     689     725 .. 0.86
  17 !   17.7   0.0   6.1e-07    0.0022       1      35 [.     705     738 ..     705     751 .. 0.88
  18 !   26.4   0.1   1.2e-09   4.1e-06       1      43 [.     754     797 ..     754     800 .. 0.90
  19 !   38.8   0.5   1.6e-13   5.7e-10       3      47 ..     806     848 ..     804     849 .. 0.94
  20 !   10.9   0.1   7.9e-05      0.28       3      37 ..     855     889 ..     853     901 .. 0.91
  21 !   41.1   0.0     3e-14   1.1e-10       1      49 []     902     950 ..     902     950 .. 0.95
  22 !   28.7   0.0   2.2e-10     8e-07       1      49 []     952    1000 ..     952    1000 .. 0.97
  23 !   46.9   0.1   4.4e-16   1.6e-12       1      47 [.    1002    1048 ..    1002    1050 .. 0.96
  24 !   16.6   0.1   1.4e-06    0.0049       2      41 ..    1053    1092 ..    1053    1100 .. 0.88
  25 !   25.6   0.2     2e-09   7.3e-06       1      46 [.    1102    1147 ..    1102    1151 .. 0.85
  26 !   40.7   0.2     4e-14   1.4e-10       1      47 [.    1153    1199 ..    1153    1202 .. 0.94
  27 !   29.9   0.1   9.6e-11   3.4e-07       1      46 [.    1204    1249 ..    1204    1252 .. 0.96
  28 !   17.7   0.1   6.2e-07    0.0022       8      46 ..    1261    1299 ..    1254    1302 .. 0.90
  29 !   36.5   0.1   8.4e-13     3e-09       1      49 []    1303    1352 ..    1303    1352 .. 0.96
  30 !   35.6   0.4   1.6e-12   5.6e-09       7      49 .]    1335    1377 ..    1335    1377 .. 0.97
  31 !   36.1   0.5   1.1e-12   3.8e-09       1      49 []    1354    1402 ..    1354    1402 .. 0.98
  32 !   45.7   0.0   1.1e-15     4e-12       1      49 []    1379    1427 ..    1379    1427 .. 0.96
  33 !   44.2   0.0   3.2e-15   1.2e-11       4      49 .]    1407    1452 ..    1404    1452 .. 0.96
  34 !   26.9   0.4   8.1e-10   2.9e-06       5      49 .]    1478    1522 ..    1478    1522 .. 0.96
  35 !   39.9   0.0   6.8e-14   2.4e-10       1      49 []    1524    1572 ..    1524    1572 .. 0.97
  36 !   25.2   0.1   2.8e-09   9.9e-06       2      36 ..    1575    1609 ..    1574    1611 .. 0.93
  37 !   30.9   0.1   4.5e-11   1.6e-07      11      44 ..    1610    1643 ..    1609    1648 .. 0.94
  38 !   27.5   0.2   5.2e-10   1.9e-06       1      46 [.    1649    1694 ..    1649    1697 .. 0.96
  39 !   18.8   0.1   2.6e-07   0.00095       1      44 [.    1674    1717 ..    1674    1720 .. 0.94
  40 !   15.4   0.0   3.3e-06     0.012       2      47 ..    1722    1766 ..    1721    1768 .. 0.94

  Alignments for each domain:
  == domain 1  score: 42.4 bits;  conditional E-value: 1.1e-14
     DUF4116   5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                  l+a+ k g+ l+++s++L+nDke+vl A+k ++++++yas+eL+
  EFC39538.1  92 FLKALPKRGNLLENASDSLRNDKELVLLAIKEDKSSIKYASDELK 136
                 589999*************************************97 PP

  == domain 2  score: 50.9 bits;  conditional E-value: 2.7e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEi+l +++  gs+l+yls+eLk D eiv+ Av+++g+a+ +aseeLr
  EFC39538.1 138 DREIALIVLEDAGSNLEYLSDELKADYEIVKIAVQNDGDAFQFASEELR 186
                 9***********************************************8 PP

  == domain 3  score: 40.9 bits;  conditional E-value: 3.4e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk..qngtalsyaseeLr 49 
                 D+E++l a++k gsal++++eeLk D++iv+ A+    ngt++s+a++++r
  EFC39538.1 188 DKELALIALDKSGSALEFCPEELKADIDIVISAIAksYNGTVFSHAHPKFR 238
                 9**********************************55599*******9987 PP

  == domain 4  score: 22.3 bits;  conditional E-value: 2.2e-08
     DUF4116  13 gsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 gs    ls+eLk+D+e+v + +  ng+ l+ ++eeL+
  EFC39538.1 261 GSLVSDLSDELKQDREVVEAVLLVNGSDLREIPEELQ 297
                 3344459****************************97 PP

  == domain 5  score: 47.9 bits;  conditional E-value: 2.2e-16
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr++vl+avk++g++ +y+ +e+k+D ei+l+A+ +n  a  y+s+eL+
  EFC39538.1 299 DRDLVLKAVKSDGYVMEYVVDEFKSDQEIALAAISSNARACGYVSDELK 347
                 9**********************************************97 PP

  == domain 6  score: 35.6 bits;  conditional E-value: 1.5e-12
     DUF4116  18 ylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 y+s+eLk+D+e+v++A+k+n ++l+y++++L+
  EFC39538.1 341 YVSDELKQDREFVKQAIKINADVLEYVDDSLK 372
                 9****************************997 PP

  == domain 7  score: 53.3 bits;  conditional E-value: 4.6e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+v++a+k+n  +l+y++++Lk D+eiv+ Av++ng + +yas++L+
  EFC39538.1 349 DREFVKQAIKINADVLEYVDDSLKDDREIVKMAVRKNGRIVEYASDNLK 397
                 9*********************************************997 PP

  == domain 8  score: 51.5 bits;  conditional E-value: 1.7e-17
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrEiv+ av+kng + +y+s++LknD ei+l A++ ++ alsy+s++++
  EFC39538.1 374 DREIVKMAVRKNGRIVEYASDNLKNDEEIALIALEEDPRALSYLSDDIK 422
                 9*********************************************986 PP

  == domain 9  score: 52.4 bits;  conditional E-value: 8.8e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Ei+l a++ ++ al yls+++kn++eiv+kA+++ng++l+yas+e++
  EFC39538.1 399 DEEIALIALEEDPRALSYLSDDIKNNIEIVKKALRKNGSVLEYASDEIK 447
                 9**********************************************96 PP

  == domain 10  score: 54.2 bits;  conditional E-value: 2.4e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + Eiv++a++kngs+l+y+s+e+k ++eiv++A+k  g+al++a+ee +
  EFC39538.1 424 NIEIVKKALRKNGSVLEYASDEIKENIEIVKAAIKVRGSALEFAPEEVK 472
                 68********************************************975 PP

  == domain 11  score: 56.4 bits;  conditional E-value: 4.8e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + Eiv+ a+k  gsal++++ee k+D+eiv++Av+q+g+al yas+eL+
  EFC39538.1 449 NIEIVKAAIKVRGSALEFAPEEVKSDREIVKQAVRQDGSALAYASDELK 497
                 68*********************************************97 PP

  == domain 12  score: 36.8 bits;  conditional E-value: 6.5e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 D Eiv+ a+++n +al+y+s+++knD++++l+++k  +
  EFC39538.1 499 DFEIVKLALSSNTNALQYVSDNIKNDRDLCLQIIKLKS 536
                 88*********************************765 PP

  == domain 13  score: 40.5 bits;  conditional E-value: 4.5e-14
     DUF4116  10 kkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++ gs+l+yl++e+knD+eiv++ vk+ng  l++as eL+
  EFC39538.1 539 SRWGSILEYLNDEMKNDREIVMELVKNNGRELEFASAELK 578
                 56699*******************************9997 PP

  == domain 14  score: 54.6 bits;  conditional E-value: 1.8e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eivl av+ ngsal+y+s++LknD+ +vl+Av ++g+al+y s+eL+
  EFC39538.1 580 DKEIVLMAVSENGSALEYASSDLKNDRGVVLRAVMKSGDALEYTSKELK 628
                 9**********************************************97 PP

  == domain 15  score: 32.3 bits;  conditional E-value: 1.7e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 DrEiv  a++ +g a+ ++s+eLk+D+ +v+ A++++g +l+y+ +
  EFC39538.1 630 DREIVSTAIRMDGRAFAHASDELKKDISLVMVALENDGRVLEYVTK 675
                 9******************************************976 PP

  == domain 16  score: 21.1 bits;  conditional E-value: 5.4e-08
     DUF4116  12 ngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 n ++lk++se+L++D+e+++  ++ ng +++ ++
  EFC39538.1 691 NYNSLKFASERLRSDREFAKTVCQFNGGNIEDLP 724
                 899******************9999987776665 PP

  == domain 17  score: 17.7 bits;  conditional E-value: 6.1e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 DrE+++ +++ ng +++ l+ ++k D+ei+l  + 
  EFC39538.1 705 DREFAKTVCQFNGGNIEDLP-KFKGDREIALLSLL 738
                 9*******************.********997665 PP

  == domain 18  score: 26.4 bits;  conditional E-value: 1.2e-09
     DUF4116   1 DrEivleavkkngsalky.lseeLknDkeivlkAvkqngtalsy 43 
                 DrE++++++++   +  + lseeL +D++++++ +k+ng++l  
  EFC39538.1 754 DREFMTKLLDHGIAVEPKiLSEELLSDRDFIKRLIKNNGSVLQE 797
                 9**********987777758********************9975 PP

  == domain 19  score: 38.8 bits;  conditional E-value: 1.6e-13
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 Ei ++a+k   s+++y+++eL++D+eiv+kA+k +g++l+y+++e
  EFC39538.1 806 EIYMNALKC--SYIRYFPSELQSDREIVKKALKMDGSILRYIDDE 848
                 899999999..99*****************************997 PP

  == domain 20  score: 10.9 bits;  conditional E-value: 7.9e-05
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqn 37 
                 E+v+ +v+  +++++++ +e+ ++ ++v+ Avk  
  EFC39538.1 855 ELVKICVRDSSYVFEHACKEFASNLQVVMTAVKER 889
                 9********************************65 PP

  == domain 21  score: 41.1 bits;  conditional E-value: 3e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +r++v+ av  +g +l+y+seeLk D+eiv+ Av+ ng+al +a  eLr
  EFC39538.1 902 NRDFVKFAVYLDGRCLEYASEELKADREIVKIAVQENGDALAFAALELR 950
                 8****************************************99977766 PP

  == domain 22  score: 28.7 bits;  conditional E-value: 2.2e-10
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  D Eivleav+  g al ++ ++++nD+ iv  Av+++ ta++yas eL+
  EFC39538.1  952 DYEIVLEAVRCSGGALLFAGSKFTNDRYIVTTAVENYYTAFRYASAELQ 1000
                  569******************************************9996 PP

  == domain 23  score: 46.9 bits;  conditional E-value: 4.4e-16
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47  
                  DrE+v+ +++k +++++yl+ eL nDkei++ A++++g+ ++ya+ +
  EFC39538.1 1002 DREFVMRIIEKEPNVYEYLPVELLNDKEILMTAIRKSGDLIKYAPLH 1048
                  9*******************************************955 PP

  == domain 24  score: 16.6 bits;  conditional E-value: 1.4e-06
     DUF4116    2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtal 41  
                  r++ + a+++  ++++y++ eL+nD  +v+ A+ ++g  +
  EFC39538.1 1053 RDVYMTAIQSSKYSINYIPFELRNDPKLVKIALPSCGLEY 1092
                  8999****************************99998776 PP

  == domain 25  score: 25.6 bits;  conditional E-value: 2e-09
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46  
                  DrE++l av  n  ++ky++e+++nD e++ +A+ + + +l  +++
  EFC39538.1 1102 DRELCLRAVIENRDNIKYVPEKFRNDPEFISEALVKQPLVLAKLPD 1147
                  9*******9999999******************7666666666665 PP

  == domain 26  score: 40.7 bits;  conditional E-value: 4e-14
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47  
                  D++  l++v++ g+ l+yl+e++k+D+eiv+ A++ +g++l y+ +e
  EFC39538.1 1153 DKQALLKLVRIEGCLLEYLPENIKKDREIVMTAIQEYGSSLQYVFDE 1199
                  78889***************************************965 PP

  == domain 27  score: 29.9 bits;  conditional E-value: 9.6e-11
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46  
                  D+Ei+l a+k++ sa++y+ e+L +D+++vl+ +   g +l+y++e
  EFC39538.1 1204 DKEIALAAMKTDRSAIRYVHESLLSDRDVVLASLYYEGASLKYLDE 1249
                  9*************************************99*99987 PP

  == domain 28  score: 17.7 bits;  conditional E-value: 6.2e-07
     DUF4116    8 avkkngsalkylseeLknDkeivlkAvkqngtalsyase 46  
                  avk    +lky+s +L  Dke+ + Av+ ++ta++ya+ 
  EFC39538.1 1261 AVKESYDSLKYVSIDLWEDKEFTKYAVECDSTAIRYACS 1299
                  7898999*****************************985 PP

  == domain 29  score: 36.5 bits;  conditional E-value: 8.4e-13
     DUF4116    1 DrEivleavkkng.salkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  D+Ei+  a+ + g ++l+yl+ +L+n +e++lkAv +ng++++y+ e+L+
  EFC39538.1 1303 DKEIANAALNHKGvEILQYLPLDLRNEREFALKAVANNGDSIKYLNEHLK 1352
                  99********99868********************************997 PP

  == domain 30  score: 35.6 bits;  conditional E-value: 1.6e-12
     DUF4116    7 eavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  +av +ng ++kyl+e Lk D eiv +A++++++a++++s+e++
  EFC39538.1 1335 KAVANNGDSIKYLNEHLKEDLEIVERAIESSKDAYKFISKEMQ 1377
                  79**************************************986 PP

  == domain 31  score: 36.1 bits;  conditional E-value: 1.1e-12
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  D Eiv  a+++   a+k++s+e++n+ ++ lk vk++g  l+yas++L+
  EFC39538.1 1354 DLEIVERAIESSKDAYKFISKEMQNNEQVTLKVVKKDGLLLDYASNDLK 1402
                  89*********************************************97 PP

  == domain 32  score: 45.7 bits;  conditional E-value: 1.1e-15
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  ++++ l++vkk+g+ l y+s++Lkn+  +vl+Avkqng+a+++ase++r
  EFC39538.1 1379 NEQVTLKVVKKDGLLLDYASNDLKNNLSVVLAAVKQNGSAIRFASEDMR 1427
                  57788*****************************************997 PP

  == domain 33  score: 44.2 bits;  conditional E-value: 3.2e-15
     DUF4116    4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  +vl avk+ngsa++++se+++n+k+++l A++q+g+++ y+s+eL+
  EFC39538.1 1407 VVLAAVKQNGSAIRFASEDMRNNKQVALVALNQSGKSFVYLSKELQ 1452
                  8*******************************************97 PP

  == domain 34  score: 26.9 bits;  conditional E-value: 8.1e-10
     DUF4116    5 vleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  ++ea+ +   +lk +s++Lk+D  +vl + k+n ++l++ase L+
  EFC39538.1 1478 IKEAINHRATILKLASDDLKSDSKFVLDCFKKNRKSLKHASETLK 1522
                  6899999999********************************997 PP

  == domain 35  score: 39.9 bits;  conditional E-value: 6.8e-14
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49  
                  DrE++l a+ +ng+al+yl   +++D eiv kAv  ng al++as +L+
  EFC39538.1 1524 DREFALLAIAINGLALEYLAIPFRSDYEIVQKAVSVNGRALKFASADLQ 1572
                  9*****************9999***********************8885 PP

  == domain 36  score: 25.2 bits;  conditional E-value: 2.8e-09
     DUF4116    2 rEivleavkkngsalkylseeLknDkeivlkAvkq 36  
                  ++ivl avk++g+a k++++eLk+D ei++  +k 
  EFC39538.1 1575 KQIVLDAVKNCGLAVKFAPSELKKDLEIAKISLKT 1609
                  79***************************998885 PP

  == domain 37  score: 30.9 bits;  conditional E-value: 4.5e-11
     DUF4116   11 kngsalkylseeLknDkeivlkAvkqngtalsya 44  
                  +ng+++++l+e+L+nD e+v + vk++g+++ ++
  EFC39538.1 1610 SNGKSFEFLDESLRNDDEFVRESVKRYGNCIQFL 1643
                  79*****************************998 PP

  == domain 38  score: 27.5 bits;  conditional E-value: 5.2e-10
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46  
                  +rE++  a+kkng  l yl++e++ Dke+v  A +q+ ++++yas 
  EFC39538.1 1649 NRELCELALKKNGRLLDYLPNEYTFDKELVAVATNQCVNSIRYASR 1694
                  8*******************************************95 PP

  == domain 39  score: 18.8 bits;  conditional E-value: 2.6e-07
     DUF4116    1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44  
                  D+E+v  a  ++ ++++y+s  L++D+e++  ++k+n++ +++a
  EFC39538.1 1674 DKELVAVATNQCVNSIRYASRFLRSDIEFMTPIIKKNPFLIRHA 1717
                  8999999999****************************998876 PP

  == domain 40  score: 15.4 bits;  conditional E-value: 3.3e-06
     DUF4116    2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyasee 47  
                  +++v+ av++ng++l+ l e++  +ke v  A+ qn++a++y+ e 
  EFC39538.1 1722 EDMVKVAVSTNGLVLRRLAERFI-NKETVRIAISQNKHAIRYVGEG 1766
                  7999******************9.9*****************9875 PP

>> DUF1667  Protein of unknown function (DUF1667)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.1   0.0   0.00078       2.8       5      46 ..     440     483 ..     437     499 .. 0.90
   2 ?    0.9   0.0      0.13   4.6e+02       5      33 ..     546     574 ..     545     589 .. 0.78
   3 ?    0.1   0.0      0.23   8.3e+02       5      31 ..     571     597 ..     566     605 .. 0.86
   4 !    4.6   0.0    0.0092        33       5      38 ..     621     654 ..     617     662 .. 0.83
   5 ?   -2.7   0.0       1.7   6.2e+03       5      25 ..     869     889 ..     869     893 .. 0.86
   6 ?    0.9   0.0      0.13   4.6e+02       5      29 ..     918     942 ..     915     958 .. 0.85
   7 ?   -3.8   0.0       3.8   1.4e+04       6      23 ..     969     986 ..     968     987 .. 0.86
   8 ?   -0.8   0.0      0.46   1.6e+03       6      35 ..     994    1023 ..     992    1049 .. 0.61
   9 ?   -2.3   0.0       1.3   4.7e+03       5      29 ..    1395    1419 ..    1394    1423 .. 0.86
  10 ?   -3.0   0.0       2.2     8e+03       5      41 ..    1565    1601 ..    1562    1606 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00078
     DUF1667   5 eYakkEvtnpkRivtstvkveggelplvp..Vktsepipkekif 46 
                 eYa +E+++   iv + +kv+g++l+  p  Vk++++i k+ + 
  EFC39538.1 440 EYASDEIKENIEIVKAAIKVRGSALEFAPeeVKSDREIVKQAVR 483
                 7********************9998887666*******998875 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.13
     DUF1667   5 eYakkEvtnpkRivtstvkveggelplvp 33 
                 eY ++E++n + iv+ +vk +g el+  +
  EFC39538.1 546 EYLNDEMKNDREIVMELVKNNGRELEFAS 574
                 68899999999999999999988877655 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.23
     DUF1667   5 eYakkEvtnpkRivtstvkveggelpl 31 
                 e+a +E++n k iv   v  +g++l+ 
  EFC39538.1 571 EFASAELKNDKEIVLMAVSENGSALEY 597
                 79*************999999887665 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.0092
     DUF1667   5 eYakkEvtnpkRivtstvkveggelplvpVktse 38 
                 eY  kE++n + iv + ++++g +++  +   ++
  EFC39538.1 621 EYTSKELKNDREIVSTAIRMDGRAFAHASDELKK 654
                 79******************99887766655555 PP

  == domain 5  score: -2.7 bits;  conditional E-value: 1.7
     DUF1667   5 eYakkEvtnpkRivtstvkve 25 
                 e+a kE+ +  ++v++ vk +
  EFC39538.1 869 EHACKEFASNLQVVMTAVKER 889
                 58999999********99865 PP

  == domain 6  score: 0.9 bits;  conditional E-value: 0.13
     DUF1667   5 eYakkEvtnpkRivtstvkveggel 29 
                 eYa +E+++ + iv   v+ +g++l
  EFC39538.1 918 EYASEELKADREIVKIAVQENGDAL 942
                 8**************9999988765 PP

  == domain 7  score: -3.8 bits;  conditional E-value: 3.8
     DUF1667   6 YakkEvtnpkRivtstvk 23 
                 +a + +tn + ivt+ v+
  EFC39538.1 969 FAGSKFTNDRYIVTTAVE 986
                 78889999*******985 PP

  == domain 8  score: -0.8 bits;  conditional E-value: 0.46
     DUF1667    6 YakkEvtnpkRivtstvkveggelplvpVk 35  
                  Ya +E+   +  v+ +++ e + ++ +pV 
  EFC39538.1  994 YASAELQRDREFVMRIIEKEPNVYEYLPVE 1023
                  666666666666666666666666666664 PP

  == domain 9  score: -2.3 bits;  conditional E-value: 1.3
     DUF1667    5 eYakkEvtnpkRivtstvkveggel 29  
                  +Ya ++++n   +v + vk +g+++
  EFC39538.1 1395 DYASNDLKNNLSVVLAAVKQNGSAI 1419
                  6*****************9998765 PP

  == domain 10  score: -3.0 bits;  conditional E-value: 2.2
     DUF1667    5 eYakkEvtnpkRivtstvkveggelplvpVktsepip 41  
                  ++a +++ n k+iv   vk  g +++  p   +++++
  EFC39538.1 1565 KFASADLQNTKQIVLDAVKNCGLAVKFAPSELKKDLE 1601
                  7999999999999999998887777777766666655 PP

>> DUF4853  Domain of unknown function (DUF4853)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0      0.57     2e+03      47     102 ..     253     310 ..     246     325 .. 0.74
   2 ?   -0.2   0.0      0.28     1e+03      47      99 ..     354     406 ..     318     414 .. 0.84
   3 ?    2.8   0.0     0.033   1.2e+02      15      95 ..     423     502 ..     415     518 .. 0.80
   4 ?   -2.5   0.0       1.5   5.3e+03      68     109 ..     556     596 ..     546     602 .. 0.83
   5 ?    1.0   0.0      0.12   4.4e+02      68     112 ..     631     674 ..     617     687 .. 0.88
   6 ?    2.3   0.0     0.046   1.7e+02      47      96 ..    1554    1603 ..    1545    1618 .. 0.83

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 0.57
                 G-EEEEE--EEEEE.---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEE.EEEET CS
     DUF4853  47 etgyrlasrtlyip.eidfddlrevveeelkplGfkysekpderdkdesrtv.vwgde 102
                 e+g+++   +l+ + + + ++ revve+ l  +G +++e p+e + d   ++ ++ ++
  EFC39538.1 253 EEGCSFFFGSLVSDlSDELKQDREVVEAVLLVNGSDLREIPEELQSDRDLVLkAVKSD 310
                 556666655665554455566699*******************999999988555554 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.28
                 G-EEEEE--EEEEE---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EEEEE CS
     DUF4853  47 etgyrlasrtlyipeidfddlrevveeelkplGfkysekpderdkdesrtvvw 99 
                 ++ +++++ +l+    + +d re+v+ +++++G  ++   d+ ++de+  +++
  EFC39538.1 354 KQAIKINADVLEYVDDSLKDDREIVKMAVRKNGRIVEYASDNLKNDEEIALIA 406
                 577888889999999999999*************9999999999999988854 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.033
                 HHHHTTHHHHHHHTS-EEEEE--EEEEE--GGG-EEEEE--EEEEE---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-E CS
     DUF4853  15 aiiaireelateeggelgvegkdyvsacgtgdetgyrlasrtlyipeidfddlrevveeelkplGfkysekpderdkdesr 95 
                   i+i+++ ++++g +l  + +d+++++ +  +  +++++  l+++  +++  re+v+++++++G ++    de ++d + 
  EFC39538.1 423 NNIEIVKKALRKNGSVLE-YASDEIKENIEIVKAAIKVRGSALEFAPEEVKSDREIVKQAVRQDGSALAYASDELKDDFEI 502
                 557889999999999888.778889999899999************9999999************9999988888777655 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 1.5
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEE CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyGgsls 109
                 re+v e +k +G +++    e ++d++ ++++ +e +G  l+
  EFC39538.1 556 REIVMELVKNNGRELEFASAELKNDKEIVLMAVSE-NGSALE 596
                 78999999999999999999999999999988887.787776 PP

  == domain 5  score: 1.0 bits;  conditional E-value: 0.12
                 HHHHHHT.--TTEEEEEE-SS--TTS-EEEEEEET.TS-EEEEEE CS
     DUF4853  68 revveeelkplGfkysekpderdkdesrtvvwgderyGgslsvky 112
                 re+v+++++ +G ++    de +kd s ++v+ ++ +G +l+  +
  EFC39538.1 631 REIVSTAIRMDGRAFAHASDELKKDISLVMVALEN-DGRVLEYVT 674
                 89**************************9988888.899998766 PP

  == domain 6  score: 2.3 bits;  conditional E-value: 0.046
                  G-EEEEE--EEEEE---HHHHHHHHHHT.--TTEEEEEE-SS--TTS-EE CS
     DUF4853   47 etgyrlasrtlyipeidfddlrevveeelkplGfkysekpderdkdesrt 96  
                  ++ +++++r l++++ d +   ++v +++k  G++++  p e +kd +  
  EFC39538.1 1554 QKAVSVNGRALKFASADLQNTKQIVLDAVKNCGLAVKFAPSELKKDLEIA 1603
                  67899********************************9999999987654 PP

>> CholecysA-Rec_N  Cholecystokinin A receptor, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00025      0.91       2      22 ..     276     296 ..     275     301 .. 0.90

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00025
  CholecysA-Rec_N   2 evvdaSlLgNGtnitdilCdl 22 
                      evv+a lL+NG+++ +i+ +l
       EFC39538.1 276 EVVEAVLLVNGSDLREIPEEL 296
                      9*************9998776 PP

>> IL6  Interleukin-6/G-CSF/MGF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       1.3   4.5e+03      98     115 ..     151     168 ..     116     189 .. 0.62
   2 ?    3.6   0.2     0.012        42     100     161 ..     364     429 ..     357     456 .. 0.83
   3 ?    9.9   0.1   0.00015      0.52      83     151 ..     526     596 ..     490     629 .. 0.86
   4 ?   -0.2   0.0      0.17   6.2e+02      99     145 ..    1167    1214 ..    1158    1231 .. 0.80
   5 ?    0.9   0.3     0.083     3e+02     100     150 ..    1344    1394 ..    1341    1432 .. 0.87
   6 ?    1.3   0.1     0.062   2.2e+02      98     174 ..    1662    1741 ..    1642    1752 .. 0.74

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.3
                 HHHHHHHHT--HHHHHHH CS
         IL6  98 iyleylqnkfegekenvk 115
                 + leyl ++++ + e vk
  EFC39538.1 151 SNLEYLSDELKADYEIVK 168
                 345555555555555443 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.012
                 HHHHHHT--HHHHHHHHHHHHHHHHHHHHHHHHHHHS----....----HHHHHHH--S-SS-SSH CS
         IL6 100 leylqnkfegekenvkalqkstkaliqilkqkvknleeitt....pdPttnasllaklqsqeeWlk 161
                 ley+ + +++++e vk   ++   +++    ++kn eei++     dP + + l + ++ + e +k
  EFC39538.1 364 LEYVDDSLKDDREIVKMAVRKNGRIVEYASDNLKNDEEIALialeEDPRALSYLSDDIKNNIEIVK 429
                 99************99999999999*************9873333467777777777776666665 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00015
                 -S-S..---HHHHHHHHHHHHHHHHT--HHHHHHHHHHHHHHHHHHHHHHHHHHHS--------HHHHHHH CS
         IL6  83 eicl..lkittGllefqiyleylqnkfegekenvkalqkstkaliqilkqkvknleeittpdPttnaslla 151
                 + cl  +k+ + ++ + + leyl++++++++e v +l k+    ++    ++kn +ei++     n s l+
  EFC39538.1 526 DLCLqiIKLKSSFSRWGSILEYLNDEMKNDREIVMELVKNNGRELEFASAELKNDKEIVLMAVSENGSALE 596
                 66764479999**********************9999999999999************9977666666555 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.17
                  HHHHHHHT--HHHHH.HHHHHHHHHHHHHHHHHHHHHHS--------H CS
         IL6   99 yleylqnkfegeken.vkalqkstkaliqilkqkvknleeittpdPtt 145 
                   leyl ++ ++++e  + a+q+   +l  ++ +++ + +ei++    t
  EFC39538.1 1167 LLEYLPENIKKDREIvMTAIQEYGSSLQYVFDEEILKDKEIALAAMKT 1214
                  589999999999998456788888889899999988888888765555 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.083
                  HHHHHHT--HHHHHHHHHHHHHHHHHHHHHHHHHHHS--------HHHHHH CS
         IL6  100 leylqnkfegekenvkalqkstkaliqilkqkvknleeittpdPttnasll 150 
                  ++yl+++++++ e v+   +s k   + + ++++n e++t+ +   +  ll
  EFC39538.1 1344 IKYLNEHLKEDLEIVERAIESSKDAYKFISKEMQNNEQVTLKVVKKDGLLL 1394
                  68999****99999999999999999*************997666555555 PP

  == domain 6  score: 1.3 bits;  conditional E-value: 0.062
                  HHHHHHHHT--HHHHHHHHHHHHHHHHHHHHHHHHHHHS--------HHHHHHH--S-.SS-SSH..HHHHHHHHHHHHH CS
         IL6   98 iyleylqnkfegekenvkalqkstkaliqilkqkvknleeittpdPttnasllaklqs.qeeWlk..nttiklilrsled 174 
                    l+yl n++  +ke v +  ++    i+   + ++   e  tp    n  l+   +  +e+ +k   +t  l+lr+l +
  EFC39538.1 1662 RLLDYLPNEYTFDKELVAVATNQCVNSIRYASRFLRSDIEFMTPIIKKNPFLIRHANRiSEDMVKvaVSTNGLVLRRLAE 1741
                  569*************9999999999999999999888888888888888887766541344444113466788888855 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1776 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       800  (0.0446204); expected 358.6 (0.02)
Passed bias filter:                      397  (0.0221429); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.99u 0.32s 00:00:01.31 Elapsed: 00:00:00.52
# Mc/sec: 10252.25
//
Query:       EFC39539.1  [L=1610]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      9e-15   53.9   0.0      0.051   13.6   0.0    6.3  6  NHL           NHL repeat
    2.6e-09   37.4   1.6    8.6e-09   35.7   1.6    2.0  1  RGS           Regulator of G protein signaling domain
    8.1e-09   35.9   4.5    2.1e-08   34.5   4.5    1.8  1  GPS           GPCR proteolysis site, GPS, motif
    6.9e-06   25.8   0.0    0.00022   20.9   0.0    2.8  2  SGL           SMP-30/Gluconolactonase/LRE-like region
     0.0046   16.3   0.0      0.016   14.5   0.0    1.8  1  Lactonase     Lactonase, 7-bladed beta-propeller
  ------ inclusion threshold ------
      0.012   15.8   0.0        0.2   11.9   0.0    3.2  3  Arylesterase  Arylesterase
      0.059   13.8   9.3       0.16   12.4   9.3    1.7  1  EGF_2         EGF-like domain
      0.073   12.7   0.3        0.3   10.7   0.0    2.2  2  DUF2321       Uncharacterized protein conserved in bacteria (
      0.078   13.1   0.0       0.81    9.8   0.0    2.8  2  Str_synth     Strictosidine synthase
       0.12   12.3   0.1       0.64   10.0   0.0    2.2  2  PD40          WD40-like Beta Propeller Repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.0    0.0022       3.9       7      25 ..      73      91 ..      67      94 .. 0.79
   2 ?    3.9   0.0     0.036        64       1      22 [.     128     149 ..     128     155 .. 0.90
   3 !   13.6   0.0   2.8e-05     0.051       1      28 []     230     257 ..     230     257 .. 0.93
   4 !   13.4   0.0   3.4e-05     0.061       1      28 []     289     317 ..     289     317 .. 0.94
   5 !    6.9   0.0    0.0037       6.7       3      26 ..     339     362 ..     338     364 .. 0.90
   6 ?   -2.2   0.0       3.1   5.5e+03       2      13 ..     744     756 ..     744     757 .. 0.77

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0022
                EEEETTTEEEEEECCCTEE CS
         NHL  7 vavdsnGdiyVaDsenhrv 25
                v v + + i+V Ds++hr+
  EFC39539.1 73 VLVKDANTIIVVDSGSHRL 91
                5555899***********8 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.036
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 +n+P++v+ ++++ ++ +D++n
  EFC39539.1 128 LNSPSSVVFMDSDTVLFTDTNN 149
                 799****************999 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 2.8e-05
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 ++ P+++a++s++ +y++Dse++ ++ +
  EFC39539.1 230 LQKPTSLAMSSSDILYICDSETNLIKRY 257
                 689********************99876 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 3.4e-05
                 BSSEEEEEEE.TTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqvF 28 
                 +n+P+G+a++ ++  +y+aD+ +  ++vF
  EFC39539.1 289 LNNPQGIALSpDGKMLYIADTDSGKIKVF 317
                 79********88888*************9 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0037
                 SEEEEEEETTTEEEEEECCCTEEE CS
         NHL   3 yPhGvavdsnGdiyVaDsenhrvq 26 
                  P G+ v snG +y +D+++ ++ 
  EFC39539.1 339 KPVGLYVHSNGTLYFTDTNTLQIG 362
                 69*****************98875 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 3.1
                 SSEEEEEEE.TTT CS
         NHL   2 nyPhGvavd.snG 13 
                 n P++++v+ +++
  EFC39539.1 744 NKPTDLVVFaKDN 756
                 67******95554 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.7   1.6   4.8e-12   8.6e-09       3      83 ..    1449    1531 ..    1447    1593 .. 0.81

  Alignments for each domain:
  == domain 1  score: 35.7 bits;  conditional E-value: 4.8e-12
                  HHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS CS
         RGS    3 eslledqpgrslFreFlesefseenlsFwlaveefkka..keqeelkkkakeIyneylapsspkelnidkklreelekrleke 83  
                  ++ le++  +++F +F+++efs enl+++l+  +  +   k   e+++ +++Iy+ y++++s +e+ni++++r++ ++ + k 
  EFC39539.1 1449 NQYLENPIFLKIFDSFCRKEFSLENLQLYLHLTKNSNIieKGLAEIIEFINNIYDDYVKSGSIREVNIPSDCRKSFASMVAKL 1531
                  67799****************************9999988899999****************************999888775 PP

>> GPS  GPCR proteolysis site, GPS, motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   4.5   1.2e-11   2.1e-08       2      43 ..    1041    1080 ..    1040    1082 .. 0.86

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 1.2e-11
         GPS    2 sCvfWdeeneetgsWsteGCel.tesdnknetvCsCnHLtsFA 43  
                  +C +W   ne+ ++W+t+GC+l   ++ + e+vCsC+H+t F+
  EFC39539.1 1041 ICKYW---NETMSKWDTDGCTLkSLNSATGEIVCSCTHTTLFS 1080
                  7****...7889********9874444899**********997 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.0      0.14   2.4e+02     141     165 ..     238     261 ..     202     268 .. 0.78
   2 !   20.9   0.0   1.2e-07   0.00022     126     207 ..     282     361 ..     275     368 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.14
         SGL 141 wspdgktlYlaDsltrkiwaydvda 165
                 +s+ ++ lY++Ds t+ i +y+v++
  EFC39539.1 238 MSS-SDILYICDSETNLIKRYNVSS 261
                 443.578999999999999999975 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 1.2e-07
         SGL 126 lervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge..gepDGlavDaeGnvwvAvwgggkv 207
                 l  +  +l+ p G+a+spdgk lY+aD+  +ki ++++++++     r+ +a+ k g   ++p Gl v ++G ++ +  ++ ++
  EFC39539.1 282 LDPLSHNLNNPQGIALSPDGKMLYIADTDSGKIKVFNIEKNTI----RTILAESKYGIsvSKPVGLYVHSNGTLYFTDTNTLQI 361
                 56677889999***************************87776....4444444433344448888888888888776666555 PP

>> Lactonase  Lactonase, 7-bladed beta-propeller
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.0   8.7e-06     0.016     289     326 ..     288     325 ..     280     345 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 8.7e-06
                 SSS.--EEEE-TTSSEEEEEETTTTEEEEEEEETTTTE CS
   Lactonase 289 egkfPRdfaldpsgklllvanqksdnvtvferdaetGk 326
                 + ++P  +al+p+gk+l++a+ +s+++ vf+++++t +
  EFC39539.1 288 NLNNPQGIALSPDGKMLYIADTDSGKIKVFNIEKNTIR 325
                 56789999***********************9999854 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       3.8   6.8e+03      52      84 ..     229     260 ..     222     262 .. 0.79
   2 ?   11.9   0.0   0.00011       0.2      52      85 ..     288     321 ..     278     322 .. 0.84
   3 ?   -2.9   0.0       4.5   8.2e+03       6      39 ..     828     861 ..     827     875 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 3.8
  Arylesterase  52 glssanGInidadkkyiyvadilresihvmkkh 84 
                   gl+ ++ + +++ + ++y+ d+  + i ++++ 
    EFC39539.1 229 GLQKPTSLAMSSSD-ILYICDSETNLIKRYNVS 260
                   67778888887754.99****999999999876 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00011
  Arylesterase  52 glssanGInidadkkyiyvadilresihvmkkhk 85 
                    l+ + GI +++d k++y+ad    +i v++ +k
    EFC39539.1 288 NLNNPQGIALSPDGKMLYIADTDSGKIKVFNIEK 321
                   6889*****************9888887776655 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 4.5
  Arylesterase   6 vGpdsfyatndhyFgdnfllllemslqlawtavv 39 
                   vG+ s+y   ++  ++    l++  l+   ++ v
    EFC39539.1 828 VGLGSLYSMSEKNLTTSVSNLIIQNLDSYLGNSV 861
                   8999999999999999988888888887766644 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   9.3   8.8e-05      0.16       5      32 .]     391     417 ..     388     417 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 8.8e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+G C ++   C+C  g+ G++C
  EFC39539.1 391 SSVCSGRGNCAKTD-TCSCRVGFVGNQC 417
                 789*******8555.8************ PP

>> DUF2321  Uncharacterized protein conserved in bacteria (DUF2321)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       4.2   7.6e+03      33      48 ..     453     468 ..     451     470 .. 0.82
   2 ?   10.7   0.0   0.00017       0.3      70     117 ..    1518    1567 ..    1498    1573 .. 0.81

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.2
     DUF2321  33 GektitkcpkCsteir 48 
                 G + i +c kC ++i 
  EFC39539.1 453 GINFIWNCEKCAMPID 468
                 6778999****99995 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00017
     DUF2321   70 kkCgkpyPWtkakleaak..elieeleelsddekeklkaslpdllvdtpk 117 
                  + C k++    akl+ a+  el++e++ +s+ +k++l a+l+d++vd+ k
  EFC39539.1 1518 SDCRKSFASMVAKLKNANnlELVDEKQSVSKTKKNSLPANLSDMVVDNIK 1567
                  4677888888899998874478*************************976 PP

>> Str_synth  Strictosidine synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.0   0.00045      0.81      10      82 ..     242     315 ..     234     322 .. 0.74
   2 ?   -1.5   0.0       1.5   2.8e+03       4      18 ..     344     357 ..     342     360 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00045
   Str_synth  10 gvlyftdsSsky.drrqvllallegdktGrllkydkstkvvkvlldkLyfanGialsedgsfvlvcetamkris 82 
                 ++ly+ ds ++  +r++v+  lle         +  +  +   l ++L  + Gials+dg+ + +++t   +i+
  EFC39539.1 242 DILYICDSETNLiKRYNVSSKLLETVVGSGENPFTSENDALDPLSHNLNNPQGIALSPDGKMLYIADTDSGKIK 315
                 7777777766651447777777776665555677777778888999*******************999888765 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.5
   Str_synth   4 dvdeetgvlyftdsS 18 
                  v+++ g lyftd+ 
  EFC39539.1 344 YVHSN-GTLYFTDTN 357
                 57888.*******75 PP

>> PD40  WD40-like Beta Propeller Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   0.0   0.00036      0.64      13      28 ..     294     309 ..     287     317 .. 0.81
   2 ?   -2.5   0.1         3   5.4e+03       4      19 ..     931     946 ..     930     947 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00036
                 EEEE-TTSSEEEEEEE CS
        PD40  13 aPsfSPDGkrlaFsSd 28 
                 ++++SPDGk+l+++ +
  EFC39539.1 294 GIALSPDGKMLYIADT 309
                 689*********9866 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 3
                 --SSSS.EEEEEE-TT CS
        PD40   4 ltntpgnegaPsfSPD 19 
                 +t+ + n++  sfS+D
  EFC39539.1 931 ITSANINITYSSFSKD 946
                 5666778899999999 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1610 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1328  (0.0740699); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 1.00u 0.35s 00:00:01.35 Elapsed: 00:00:00.56
# Mc/sec: 8653.35
//
Query:       EFC39540.1  [L=367]
Description: hypothetical protein NAEGRDRAFT_72728 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.3e-98  329.0   0.0    1.8e-97  326.5   0.0    1.8  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  326.5   0.0    1e-101   1.8e-97       5     406 ..       2     366 ..       1     367 [] 0.96

  Alignments for each domain:
  == domain 1  score: 326.5 bits;  conditional E-value: 1e-101
       Actin   5 savVlDnGssttraGyagedaPkavipslvgkprgrkvea.....klyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeehpll 98 
                 +++++DnGs  +++Gy+  + P +++p+l+gkp++  + +      +yvg++a +k + ++ r+p+e G+++dwd+++++w++ + + ++  +e+  +l
  EFC39540.1   2 QTLIVDNGSFKIKLGYSNSELP-LDFPTLLGKPKQIYNWQgygdkGDYVGEDAANKGGIIQARYPMEYGIITDWDDMTRIWNYGFNK-FNGSREDELIL 98 
                 79*******************9.79********99866558888899*************************************976.9999******* PP

       Actin  99 ltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGk.aLteqlkellssknvevtp 196
                 ++e++  p++ rek+++i+fE f++ ++y+a + vl+++ sg +tg+v+D G+s t ++p+++G +L++++ ++++ ++  + +++ el++s+      
  EFC39540.1  99 MSENCGVPKSHREKMTQIMFEDFNFGGMYVALQGVLALYGSGNTTGVVLDGGESCTRAIPIYEGHALHNSVLELKFVSRdVIVDNMVELFKSR------ 191
                 ***************************************************************************87751689*********8...... PP

       Actin 197 rylikkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesal 295
                                         +++++t++e+++++eiKe   +v+ + e++ + s++s+  +YeLPDg+ i++g+eRfk +E+LF p++ g+e+a 
  EFC39540.1 192 ------------------------NYEFRTTSEKRIVREIKELFGYVALNYEEELKLSEESILIDYELPDGTIINIGKERFKSTEVLFSPNIFGMEEA- 265
                 ........................799*********************************************************************99. PP

       Actin 296 eeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEY 394
                         g++e+++++i ++d d+r+e+++niv++GG+++++g+ eR++kel++ + + +k+ +   + +r y +W GG i+Asl++f+++++ ++EY
  EFC39540.1 266 --------GVAEIVFNSIGKSDLDMRREFFSNIVLAGGTTMFRGFAERMHKELSE-LAPTMKIHVKDLP-NRNYLTWKGGCIFASLSNFNNMCIKREEY 354
                 ........***********************************************.6677999999999.***************************** PP

       Actin 395 eEqGssvverkc 406
                 eE+G+ +v+r+c
  EFC39540.1 355 EESGPTIVHRRC 366
                 ***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (367 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       394  (0.0219756); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.50
# Mc/sec: 2195.96
//
Query:       EFC39541.1  [L=169]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.1e-13   49.8   0.4    4.8e-13   49.1   0.4    1.4  1  MAPEG           MAPEG family
  ------ inclusion threshold ------
      0.022   14.0   0.1      0.029   13.6   0.1    1.2  1  ABC_membrane_3  ABC transporter transmembrane region


Domain annotation for each model (and alignments):
>> MAPEG  MAPEG family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.1   0.4   5.4e-17   4.8e-13      20     129 ..      41     163 ..      11     164 .. 0.75

  Alignments for each domain:
  == domain 1  score: 49.1 bits;  conditional E-value: 5.4e-17
                 HHHHHHTT--SS---S...........SH....HHHHHHHHHHHHHHHHHHHHHHHHHHHHH.T..............-HHHHHHHHHHHHHHHHHHHH CS
       MAPEG  20 vkerrkakiaigegkana.....pralddklppklqrairahgNflEyvplfllavllaeltga..............etglaallaaafvvaRvlhal 99 
                 +++ +k+k +       +     +++++   + +++ a + h+N++E+v +f+ +++ + +                 ++ + ++l+a+f+++R+++++
  EFC39541.1  41 MATKKKQKQGVN-----NsdsslEDQKPSSWASRAELAGNIHRNDIENVLPFIMIAIPYVIVSTmsynsttdpqyslwNAIVGNILMASFTLSRMVYFF 134
                 333333333222.....1444454444444555777799**********9999999988886446889999999988889999**************** PP

                 HHHH-..SGGGHHHHHHHHHHHHHHHHHHH CS
       MAPEG 100 gyiaggpppgRslgflltllvllvlsllal 129
                 +y  +  +p+R+l+++ +ll +++l ++++
  EFC39541.1 135 MYWFN-LQPWRTLVWFWGLLSTVSLGIYTI 163
                 ****9.******************998776 PP

>> ABC_membrane_3  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1   3.2e-06     0.029      38     131 ..       8     100 ..       4     139 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3.2e-06
  ABC_membrane_3  38 ddllagkvaqlliyalvvllliligaarrivDTRaysrIyaelavevvleqrqqdldtSkvaarlalsrelv.dFlEkhlPtlitavvsivgavv 131
                     +++l+g v ++ +++  v++   i  + +++DT a  +  ++ +v+   +   +d++ S+ a+r +l+ ++  + +E+ lP +++a+  ++++ +
      EFC39541.1   8 NAVLQGFVYNVFLLMFRVFIAAQITGVSKMIDTMATKK-KQKQGVN-NSDSSLEDQKPSSWASRAELAGNIHrNDIENVLPFIMIAIPYVIVSTM 100
                     89*******************************98665.5555555.49999******************96478**********9988777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (169 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       873  (0.0486921); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1059.39
//
Query:       EFC39542.1  [L=413]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
     0.0048   15.6   0.0     0.0078   15.0   0.0    1.2  1  DCAF17       DDB1- and CUL4-associated factor 17
  ------ inclusion threshold ------
      0.072   13.4   0.0       0.45   10.8   0.0    2.3  3  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> DCAF17  DDB1- and CUL4-associated factor 17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.0   8.7e-07    0.0078      24     114 ..     286     376 ..     279     378 .. 0.94

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 8.7e-07
      DCAF17  24 kSkspiayesgriylenyrncysslkaePkklyklpklskseKiedallcespleevlveesdekpsllaltannwllrlsadtgeelekv 114
                 +S + + y + +i l   ++cy  ++++P ++ykl +++k   i  a+ ++sp  ++   + + k +l+a+  ++ +  ++++ g+++++v
  EFC39542.1 286 ESCHGLGYSTSEIQLTFLSYCYEQAENSPLSIYKLNATQKFPSITKAMQLASPNFQTNLAALNDKRTLIAIGLKDGIQIVNVENGQVVKQV 376
                 56777899999**************************************************************************999987 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0      0.46   4.1e+03      45      81 ..     206     241 ..     190     251 .. 0.68
   2 ?   -2.1   0.0      0.55     5e+03      43      73 ..     247     276 ..     225     282 .. 0.60
   3 ?   10.8   0.0     5e-05      0.45      49      83 ..     350     383 ..     316     398 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 0.46
  ANAPC4_WD40  45 aWkpdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                   +++d+ +  +  + ++   ld++sgk+ + ++ +++
   EFC39542.1 206 VFRQDNGVVYFL-ARNTFMELDVSSGKIFNYYDWSND 241
                  555555554444.344455578899998888777666 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.55
  ANAPC4_WD40  43 sLaWkpdgklLavaysdgevrlldaesgkvv 73 
                  ++a+  +g  + + y+++ ++++++++  +v
   EFC39542.1 247 KMAYAGNGW-FSIIYNNNLLSFYSIKNNYIV 276
                  555555553.456677777777777777666 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 5e-05
  ANAPC4_WD40  49 dgklLavaysdgevrlldaesgkvvhslsvkseka 83 
                  + +l+a++ +dg ++++++e+g+vv++++ +s ++
   EFC39542.1 350 KRTLIAIGLKDG-IQIVNVENGQVVKQVPRESGTS 383
                  456899999999.8**************9998864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (413 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       687  (0.0383178); expected 358.6 (0.02)
Passed bias filter:                      513  (0.0286129); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2369.80
//
Query:       EFC39543.1  [L=705]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.6e-32  113.2  10.5      3e-19   69.6   0.0    2.9  3  UvrD_C           UvrD-like helicase C-terminal domain
    4.2e-30  105.4  13.2    1.2e-20   74.2   5.9    3.4  4  UvrD-helicase    UvrD/REP helicase N-terminal domain
    6.6e-24   84.9   0.1    2.3e-23   83.1   0.0    2.0  2  AAA_19           AAA domain
    9.4e-12   44.6   0.4    1.2e-10   41.0   0.4    2.3  1  UvrD_C_2         UvrD-like helicase C-terminal domain
      0.001   18.5   0.1      0.054   12.9   0.0    3.3  4  PhoH             PhoH-like protein
     0.0015   18.3   0.0      0.062   13.0   0.0    2.5  1  AAA_30           AAA domain
     0.0015   18.2   5.9      0.016   14.8   0.0    3.2  3  AAA_12           AAA domain
     0.0049   16.6   0.2         22    4.7   0.0    4.0  3  Viral_helicase1  Viral (Superfamily 1) RNA helicase
      0.006   16.4   3.0     0.0076   16.1   0.0    2.3  2  AAA_11           AAA domain
  ------ inclusion threshold ------
      0.013   15.3   0.2       0.13   12.2   0.2    2.6  2  DUF2373          Uncharacterised conserved protein (DUF2373)
      0.031   14.5   1.1        2.5    8.4   0.1    2.9  2  AAA_22           AAA domain
      0.043   13.6   0.6        1.4    8.7   0.4    2.6  2  AAA_26           AAA domain
      0.052   13.3   0.0       0.13   12.0   0.0    1.7  1  HTH_38           Helix-turn-helix domain
      0.053   13.9   0.8      0.053   13.9   0.8    2.9  3  DUF4200          Domain of unknown function (DUF4200)
      0.089   12.9   0.2        6.3    7.0   0.0    3.5  3  Hydrolase_6      Haloacid dehalogenase-like hydrolase
       0.09   12.9   3.5      0.043   13.9   0.6    1.9  2  PseudoU_synth_2  RNA pseudouridylate synthase
       0.28   11.1   7.7      0.028   14.4   1.5    2.7  2  ResIII           Type III restriction enzyme, res subunit


Domain annotation for each model (and alignments):
>> UvrD_C  UvrD-like helicase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.1      0.72   7.6e+02     189     202 ..     209     230 ..      19     320 .. 0.61
   2 !   44.8   6.5   9.8e-15     1e-11       2     148 ..     371     513 ..     370     524 .. 0.77
   3 !   69.6   0.0   2.9e-22     3e-19     232     347 ..     531     686 ..     492     688 .. 0.62

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.72
                 x........xxxxxxxxxxxxx RF
      UvrD_C 189 l........elllkkiektaee 202
                 +        e ++k+++++ e+
  EFC39543.1 209 KgktyistkESIIKEMKEQLEK 230
                 0333333322222222222222 PP

  == domain 2  score: 44.8 bits;  conditional E-value: 9.8e-15
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      UvrD_C   2 vLekNyRStksLlkaankflenilnrralekekktvekge.kivvleaeteeeEaekiaatikallekneklediavLvRsnkdadkiskaLkkegipf 99 
                 +L +NyRS ks++ a+n+f++  +++       + +++++  i++ ++ t++ E ++ia++i+ l +k   ++dia+L+R   ++ +++  Lk+++ip+
  EFC39543.1 371 KLRRNYRSMKSIVLASNRFMKTSTEN-------SIETDSQdAITLNNFSTRDGEFQYIANQIQILNNKGVSYNDIAILMRRSTNTSELESILKNKKIPI 462
                 699*****************888888.......78888887999999***************************************************8 PP

                 xxxxxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxx..xxxxxxxxx RF
      UvrD_C 100 nvvdeekfFkreeikdilaylk...llankqdkialkrilkrl..vlgigkatv 148
                     ++   ++  + +++ ++     +  ++ ++++k i+k++  ++gig++++
  EFC39543.1 463 S---KNAKDDTRVMLNLMKLICdgvEIKDEKFTKSMKWIIKHFiyFKGIGEKSF 513
                 7...33335555556666555311123334444566666666411355555555 PP

  == domain 3  score: 69.6 bits;  conditional E-value: 2.9e-22
                 x.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxx............................xxxxxxxxxxxxxxxxxx RF
      UvrD_C 232 r.....kkeeklenlreLysllkelekkeeeeeveek........lneileia............................tLseseleeskkkekipi 289
                       +k++kle+  +++++++el +   ++                                                 + ++++ ++s++ + i i
  EFC39543.1 531 PtkgkaPKKDKLEKFIRFFTVINELAAGLANTT---FlklaetiqK------KfnwddpliidglglndelvtsdlidsliSFNDETYNNSSDGKGIHI 620
                 233322333366666666666666666333333...1333444440......244444444444444444444455553334445555566656***** PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx........xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
      UvrD_C 290 iTiHqAKGlEFdvVflagleegtfPsyrskk........ekrleEEkRlfYVaiTRAkkrLfisys 347
                  T+H+AKG E+  Vf+ ++++g +P   +++          +  EE R+fYVaiTRAk+ L+++ +
  EFC39543.1 621 CTVHRAKGREWKHVFVPEVQDGVMPLIKKSDpiqlkkqqIVHEGEEDRIFYVAITRAKEWLYLTNN 686
                 *************************4444436666655566789******************9976 PP

>> UvrD-helicase  UvrD/REP helicase N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.6       5.1   5.4e+03     131     192 ..      41      54 ..      11      88 .. 0.42
   2 !   44.3   0.7   1.5e-14   1.6e-11       4     152 ..     121     248 ..     118     277 .. 0.79
   3 !   74.2   5.9   1.2e-23   1.2e-20     169     314 ..     222     364 ..     211     365 .. 0.71
   4 ?   -1.9   1.1       1.8   1.9e+03     147     160 ..     484     497 ..     387     642 .. 0.57

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 5.1
                    HHHHHHHHHSCHSHTTTTHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHCHHHHHHHHHHHT CS
  UvrD-helicase 131 qqellkelleksaddslnldkkkleklikelsksrnikkeelslskskaeelrelvskakek 192
                    + e +k l                                                   +++
     EFC39543.1  41 VVEFFKPLK------------------------------------------------SKENS 54 
                    111111111................................................11111 PP

  == domain 2  score: 44.3 bits;  conditional E-value: 1.5e-14
                    HHHHHHHS.-SSEEEEEE-TTSSHHHHHHHHHHHHHHTSSSTGGGEEEEESSHHHHHHHHHHHHHHHHHCCHHCTT-HHHHHHHHHCTTSEEEEHH CS
  UvrD-helicase   4 eqreaias.lggpilveAsAGsGKTfvlaerilrlikeeeiepdrilvvTFTnkAaeElkeRieealkkaeqessdderlrlalqnlseanisTlH 98 
                    +q   i++ + + ++v A +G GKT vl+ r  + i+++   +  +l+vTF + A++E++eR+++   +                  ++ ++ T+H
     EFC39543.1 121 DQLGVIENdSAKYLVVQAPPGGGKTLVLTFRAKKIIETN--PNACLLLVTFSRDATREIQERLQKYGVE------------------KRYDVKTIH 196
                    66777777789999*****************99999988..6677********************7554..................468****** PP

                    HHHHHHHHHHHGGTT..SHTTTEEECHHHHHHCCHHHHHHHHHSCHSHTTTTHHHH CS
  UvrD-helicase  99 sfcqkilkkeanrig..ldpnfrildeedeedlkqqellkelleksaddslnldkk 152
                    +f++ i +k+  + +  +  + +i++e +e+  k++  l e +ek+     +++++
     EFC39543.1 197 AFALSICRKYGAKGKtyISTKESIIKEMKEQLEKKNVTLTETVEKYV----DWAQD 248
                    ***********998888888888888888777777777777776433....33333 PP

  == domain 3  score: 74.2 bits;  conditional E-value: 1.2e-23
                    HHHCCCHHHHHCHHHHHHHHHHHTTCCTTHHC.HSSTSCSHHHHHHHHHHHHHHHHHHHHTCEEHHHHHHHHHHHHHH.CHHHHHHHHHHSSEEEE CS
  UvrD-helicase 169 keelslskskaeelrelvskakekqlspkelk.kafekasdlqkkiaeflkeyqeqkkeenalDfsdllhallellee.neelaealrerykeili 262
                    ke ++  ++k   l e+v+k+ +  +++  ++ +a+e a+  +k++ ++++e+ + +     l +s l+ +++ +l++ ++  +++++++y  +li
     EFC39543.1 222 KEMKEQLEKKNVTLTETVEKYVDWAQDEYAREvSANEFATSDYKAALTIYEEIAKSM-----LTLSSLMREACYILTSnHQGSRDFYQQHYSDVLI 312
                    233333333333333333333333332222220222456666666666666665543.....7899***********96777899*********** PP

                    SSGGG-BHHHHHHHHHHHTTTTTEEEEE-GGG--GGGGTB-THHHHHHHHHS CS
  UvrD-helicase 263 DEyQDTnkiQyrilkllasgheelfmvGDpkQsIYgFRgAdielflkkkkdf 314
                    DE+QDT+ +Qy+++k+++ ++  + + GDp Q+IY+F gA+ ++f k  +df
     EFC39543.1 313 DEFQDTSTVQYKFMKMIIGEKTRFSVFGDPHQAIYSFLGAQEKIFDKIMEDF 364
                    *********************************************9998887 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 1.8
                    TTHHHHHHHHHHHH CS
  UvrD-helicase 147 lnldkkkleklike 160
                    ++++ +k+ k +k 
     EFC39543.1 484 VEIKDEKFTKSMKW 497
                    33333333333332 PP

>> AAA_19  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.1   0.0   2.2e-26   2.3e-23       8     145 ..     129     349 ..     122     350 .. 0.92
   2 ?   -2.9   0.0       7.4   7.8e+03     102     113 ..     629     641 ..     554     649 .. 0.60

  Alignments for each domain:
  == domain 1  score: 83.1 bits;  conditional E-value: 2.2e-26
      AAA_19   8 lkekvllvtaGpGtGKTrvlkhivallvelggvkpeeillvaftgrAakelrerlaalgae....atTiHrlal......................... 77 
                  ++k l+v a+pG GKT vl+ + + ++e++  + + +llv+f + A++e++erl+++g+e     +TiH++al                         
  EFC39543.1 129 DSAKYLVVQAPPGGGKTLVLTFRAKKIIETN--PNACLLLVTFSRDATREIQERLQKYGVEkrydVKTIHAFALsicrkygakgktyistkesiikemk 225
                 567899************************9..4477889*******************999**********99************************* PP

      AAA_19  78 .....................................................ldfddlltealelle..eaeeekklqeee.llivDEfqdvdelqyr 120
                                                                      l++ +l+ ea  +l   ++ ++++ q+++  +++DEfqd++ +qy+
  EFC39543.1 226 eqlekknvtltetvekyvdwaqdeyarevsanefatsdykaaltiyeeiaksmLTLSSLMREACYILTsnHQGSRDFYQQHYsDVLIDEFQDTSTVQYK 324
                 ******************************************999999999998888888888888888644556677778889*************** PP

      AAA_19 121 LlkallgekkklllvGDpdQliyvf 145
                 ++k + gek+++ ++GDp+Q+iy+f
  EFC39543.1 325 FMKMIIGEKTRFSVFGDPHQAIYSF 349
                 *********99************99 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 7.4
      AAA_19 102 eee.llivDEfqd 113
                 +e+ +++v E+qd
  EFC39543.1 629 REWkHVFVPEVQD 641
                 3444666666665 PP

>> UvrD_C_2  UvrD-like helicase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.0   0.4   1.1e-13   1.2e-10       3      51 ..     619     683 ..     617     684 .. 0.93

  Alignments for each domain:
  == domain 1  score: 41.0 bits;  conditional E-value: 1.1e-13
    UvrD_C_2   3 yaltihkaQGsefpaVivfdpdlaaarmgel...................rrrlLYtavTRAreklil 51 
                 ++ t+h+a+G e+++V+v  p+  +  m+ l                     r++Y+a+TRA+e+l+l
  EFC39543.1 619 HICTVHRAKGREWKHVFV--PEVQDGVMP-LikksdpiqlkkqqivhegeEDRIFYVAITRAKEWLYL 683
                 688***************..999999877.5699*********************************9 PP

>> PhoH  PhoH-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0       0.4   4.3e+02      19      46 ..     131     158 ..     119     182 .. 0.77
   2 ?   -1.5   0.0       1.4   1.4e+03      31      78 ..     210     241 ..     192     272 .. 0.58
   3 !   12.9   0.0   5.1e-05     0.054     123     158 ..     310     345 ..     302     374 .. 0.91
   4 ?   -1.0   0.0      0.98     1e+03      83     123 ..     597     636 ..     589     641 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.4
                 -SEEEEE--TTSSTTHHHHHHHHHHHHT CS
        PhoH  19 ndivfaiGpaGtGKtylavalavealkk 46 
                  + +++ +p G GKt++ +  a ++++ 
  EFC39543.1 131 AKYLVVQAPPGGGKTLVLTFRAKKIIET 158
                 45678899*******9988877776665 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.4
                 STTHHHHHHHHHHHHTTS-SEEEEEE-S-..-TT----SS---------T CS
        PhoH  31 GKtylavalavealkkkkvkriiltrpav..eageelGflpgdleekvdp 78 
                 GKty+++                     +  e++e+l   + +l+e v+ 
  EFC39543.1 210 GKTYISTKES------------------IikEMKEQLEKKNVTLTETVEK 241
                 5555554444..................3333344444444444444444 PP

  == domain 3  score: 12.9 bits;  conditional E-value: 5.1e-05
                 EEE-SGGG--HHHHHHHHTTB-TT-EEEEEE----- CS
        PhoH 123 vilDEAQnttkeqmkmfltRlGenskvvvtGdvtqi 158
                 v++DE Q+t++ q k + + +Ge++++ v Gd++q 
  EFC39543.1 310 VLIDEFQDTSTVQYKFMKMIIGEKTRFSVFGDPHQA 345
                 89*******************************996 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.98
                 HHHHHTTTS-TTCHHHHHHTTSEEEEEGGGGTT--B-SEEE CS
        PhoH  83 lydaLkdllgaekvekllekgkievaplaymRGrTlndafv 123
                 l+d+L ++ ++e++++  + + i++  ++  +Gr  ++ fv
  EFC39543.1 597 LIDSLISF-NDETYNNSSDGKGIHICTVHRAKGREWKHVFV 636
                 55555554.5788888999999************9998887 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.0   5.8e-05     0.062      15      79 ..     128     201 ..     117     407 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 5.8e-05
      AAA_30  15 tsgdrvavltGpAGtGKttalkal.reaweaa.ggrviglAptgkaAkvLaeelg...i....eastiakllkr 79 
                 ++++++ v+++p+G GKt +l+   ++++e++ +  +++++ +  a ++++e l+   +    + +ti+ +  +
  EFC39543.1 128 NDSAKYLVVQAPPGGGKTLVLTFRaKKIIETNpNACLLLVTFSRDATREIQERLQkygVekryDVKTIHAFALS 201
                 4667799**************9764899999977888999999999999**86653332444478888877644 PP

>> AAA_12  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       2.5   2.6e+03     118     151 ..     168     198 ..     151     253 .. 0.65
   2 ?    3.5   2.0     0.046        48      61     135 ..     381     459 ..     343     487 .. 0.69
   3 !   14.8   0.0   1.5e-05     0.016     141     197 ..     610     686 ..     533     688 .. 0.80

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.5
      AAA_12 118 tpYraqvellkkklkekeeeksekeievntvdgf 151
                 t+ r+  + ++++l++   ek+    +v+t+ +f
  EFC39543.1 168 TFSRDATREIQERLQKYGVEKR---YDVKTIHAF 198
                 4445555555555555544443...455555544 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.046
      AAA_12  61 eepleplvfidvekseeekekke......ksyiNeeEaelvvklvekllkkgseeerkkigvitpYraqvellkkklkeke 135
                 +  l+   f++++++++ +++++      +  + + E + +++ ++ l +kg++   ++i+++   ++  + l++ lk+k+
  EFC39543.1 381 SIVLASNRFMKTSTENSIETDSQdaitlnNFSTRDGEFQYIANQIQILNNKGVSY--NDIAILMRRSTNTSELESILKNKK 459
                 3444455666666666555555555666555667788888888888888888887..899998888888888888888654 PP

  == domain 3  score: 14.8 bits;  conditional E-value: 1.5e-05
      AAA_12 141 ke......ievntvdgfQGrekdviilslVRsn.............ekkeig.flkderrlNValTRAkskliivGn 197
                 ++      i++ tv +  Gre++ +++  V+               +k++i    ++ r + Va+TRAk+ l++  n
  EFC39543.1 610 NNssdgkgIHICTVHRAKGREWKHVFVPEVQDGvmplikksdpiqlKKQQIVhEGEEDRIFYVAITRAKEWLYLTNN 686
                 22345666************************555555556666665555442667888899********9987655 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.0     0.021        22       2      53 ..     135     184 ..     134     201 .. 0.82
   2 ?    2.2   0.0      0.12   1.2e+02      62     103 ..     306     348 ..     284     453 .. 0.66
   3 ?    4.5   0.0     0.025        26     181     231 ..     617     682 ..     591     685 .. 0.70

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.021
  Viral_helicase1   2 vvhGvpGcGKStlirkllrtsliltvnrptaelltegkpklpnlsvrtvdsf 53 
                      vv++ pG GK+ ++   +++  i+ +n++++ ll   + +++++  ++++++
       EFC39543.1 135 VVQAPPGGGKTLVLTFRAKK--IIETNPNACLLLVTFSRDATREIQERLQKY 184
                      89999**********99999..999999977777776677777777777765 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.12
  Viral_helicase1  62 kgkililDEylllhaGyill.laalskaklvilfGDplQipfh 103
                      ++  +++DE++   + + ++  + + +   + +fGDp Q  ++
       EFC39543.1 306 HYSDVLIDEFQDTSTVQYKFmKMIIGEKTRFSVFGDPHQAIYS 348
                      577789999999988888884444455567889******8776 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.025
  Viral_helicase1 181 gvrevttvhevqGltfdkVtlvllketdlelis................esrenllvAlTRhrkslv 231
                      g + + tvh + G ++++V +   ++  + li+                e++  ++vA+TR+++ l+
       EFC39543.1 617 GIH-ICTVHRAKGREWKHVFVPEVQDGVMPLIKksdpiqlkkqqivhegEEDRIFYVAITRAKEWLY 682
                      444.788888888888888776665555555556666666677777777668889999999998765 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   1.0       1.1   1.1e+03      26     175 ..      33      61 ..       5     101 .. 0.53
   2 !   16.1   0.0   7.2e-06    0.0076      19     171 ..     133     286 ..     118     320 .. 0.59

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.1
      AAA_11  26 PGtgKTktivellsqllsrrkseeeksakpriLvCapSNaAvDellerllrglldsegekykpkivRvgneeeriseavksvsleekvekrlekeekaq 124
                 P + K kt+ve+++ l                                                                                   
  EFC39543.1  33 PDSKKQKTVVEFFKPLK---------------------------------------------------------------------------------- 49 
                 33444444444444442.................................................................................. PP

      AAA_11 125 lakeiskeleklakelrafeeeeekeklkkskekskskleqerrklkkerk 175
                                                        ++e++++++ ++
  EFC39543.1  50 ---------------------------------------SKENSTSSSPSQ 61 
                 .......................................222222222222 PP

  == domain 2  score: 16.1 bits;  conditional E-value: 7.2e-06
      AAA_11  19 itliqGPPGtgKTktivellsqllsrrkseeeksakpriLvCapSNaAvDellerllr.....glldsegekykpkivRvgneeeriseavksvsleek 112
                   ++q PPG gKT +++   +++        e ++++++L+ + S  A  e+ erl +     +   ++     ++i+R + ++ ++  ++k+  ++e+
  EFC39543.1 133 YLVVQAPPGGGKTLVLTFRAKKI-------IETNPNACLLLVTFSRDATREIQERLQKygvekRYDVKTIHAFALSICRKYGAKGKTYISTKESIIKEM 224
                 5689***********99999999.......4689************************53222222222333344777766666445555555555555 PP

      AAA_11 113 vekrlekee..kaqlakeiskeleklakelrafeeeeek.eklkkskekskskleqerrklk 171
                  e+  +k+   + +  k ++ +++++a+e++a+e   ++ ++ ++ +e+ ++++ + ++ ++
  EFC39543.1 225 KEQLEKKNVtlTETVEKYVDWAQDEYAREVSANEFATSDyKAALTIYEEIAKSMLTLSSLMR 286
                 55555444344333444444444444444443333333233333333333333333344444 PP

>> DUF2373  Uncharacterised conserved protein (DUF2373)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       1.4   1.5e+03      31      51 ..      30      51 ..      25      57 .. 0.74
   2 ?   12.2   0.2   0.00012      0.13      14      49 ..     490     524 ..     476     535 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 1.4
     DUF2373 31 eeips.eyfellleYlkglkGg 51
                + ip+ + +++++e++k lk++
  EFC39543.1 30 STIPDsKKQKTVVEFFKPLKSK 51
                56665156889*******9986 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00012
     DUF2373  14 KFsKqkQnwLlkhlfdaeeipseyfellleYlkglk 49 
                 KF K    w++kh+  ++ i ++ fe  l+Ylk+ +
  EFC39543.1 490 KFTKSM-KWIIKHFIYFKGIGEKSFEKYLQYLKDQE 524
                 566654.6*************************976 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.4   0.1    0.0023       2.5       4      91 ..     130     233 ..     126     237 .. 0.73
   2 ?    4.0   0.1     0.052        55      19      86 ..     236     319 ..     233     342 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.0023
      AAA_22   4 tagilvvtGesGtGKTtllrrlleqldeeakaee..................erpevvfvtlpsst.sskdllrellralglelkaerlsseelleale 83 
                 +a+ lvv +++G GKT++l   +++  +e +                     er + + v+   +  +   ++  ++r++g ++k++  ++e +++ + 
  EFC39543.1 130 SAKYLVVQAPPGGGKTLVLTFRAKKI-IETN--PnaclllvtfsrdatreiqERLQKYGVEKRYDVkTIHAFALSICRKYGAKGKTYISTKESIIKEMK 225
                 78899************998877776.2222..245778888888877776655555566666666788888888888888888887777777778888 PP

      AAA_22  84 qalrarav 91 
                 ++l+++ v
  EFC39543.1 226 EQLEKKNV 233
                 88877765 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.052
      AAA_22  19 Ttllrrlleqldeeakaee...........erpevvfvtlpsst.sskdllrellralglelka.....erlsseellealeqal 86 
                 T ++++++++++ +++a+e           + + +++ ++++s+ ++++l+re + +l++++ +     + + s+ l++ +++ +
  EFC39543.1 236 TETVEKYVDWAQ-DEYAREvsanefatsdyKAALTIYEEIAKSMlTLSSLMREACYILTSNHQGsrdfyQQHYSDVLIDEFQDTS 319
                 678899999985.55555569999999998888888999999999*********9999998887666633333333335555555 PP

>> AAA_26  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.4    0.0013       1.4      26      97 ..      36     117 ..      32     138 .. 0.80
   2 ?    1.9   0.0      0.16   1.7e+02      74     123 ..     552     602 ..     504     605 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0013
      AAA_26  26 krkgvkvgyfKPiqtgie.........ededselikellgldqtyelpeplalsaplspelaarqegedidlekiv..kelek 97 
                 k++++ v +fKP+ ++ +         ++++++++++ + ++ ++   +p+    pl p++++++++ +id + iv   e++k
  EFC39543.1  36 KKQKTVVEFFKPLKSKENstssspsqeQEQNPDDTQSQIEVSPSSIIETPTSS-LPLHPFFQKKKKKATIDCNAIVpvVEVPK 117
                 5667789******99999888888886678*******9999998775555544.59***************999987744444 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.16
      AAA_26  74 spelaarqegedid.lekivkelekdadivvVEGagglgvpiteellnadi 123
                  +elaa + +++   l++ +++  + +d+++++G+g  ++ +t++l++  i
  EFC39543.1 552 INELAAGLANTTFLkLAETIQKKFNWDDPLIIDGLGLNDELVTSDLIDSLI 602
                 445555566555544777778888889***********9999999887765 PP

>> HTH_38  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   0.00013      0.13      11      36 ..     423     448 ..     423     448 .. 0.96

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00013
      HTH_38  11 eeIerllaeGlslreIArrLgrspsT 36 
                 ++I++l ++G s+ +IA ++ rs++T
  EFC39543.1 423 NQIQILNNKGVSYNDIAILMRRSTNT 448
                 68*********************998 PP

>> DUF4200  Domain of unknown function (DUF4200)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.8     5e-05     0.053      19      92 ..     211     284 ..     203     290 .. 0.90
   2 ?    2.5   0.2      0.18   1.9e+02      15      95 ..     350     431 ..     346     459 .. 0.84
   3 ?   -3.1   0.2       9.6     1e+04      46      56 ..     512     522 ..     510     544 .. 0.57

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 5e-05
     DUF4200  19 keeiqrleealkqreeelekkeqeleedllkfdkflkendakraralkkaeeerklkkekeaeikklkaeietl 92 
                 k  i ++e  +k+ +e+lekk+  l e+++k+    ++  a+ + a++ a +  k+     +ei+k    ++ l
  EFC39543.1 211 KTYISTKESIIKEMKEQLEKKNVTLTETVEKYVDWAQDEYAREVSANEFATSDYKAALTIYEEIAKSMLTLSSL 284
                 5568899*********************************************************9987777666 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.18
     DUF4200  15 leakkeeiqrleealkqre.eelekkeqeleedllkfdkflkendakraralkkaeeerklkkekeaeikklkaeietlkse 95 
                 l+a+++ + +++e + ++   +l+++ + ++  +l  ++f+k   +++++   + ++  ++   ++ e + + ++i+ l+++
  EFC39543.1 350 LGAQEKIFDKIMEDFPSATiLKLRRNYRSMKSIVLASNRFMKTSTENSIETDSQDAITLNNFSTRDGEFQYIANQIQILNNK 431
                 567788888888888665427999999999999*****************99999999999999999999999999988865 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 9.6
     DUF4200  46 dllkfdkflke 56 
                 +++k+ ++lk+
  EFC39543.1 512 SFEKYLQYLKD 522
                 34444444444 PP

>> Hydrolase_6  Haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.1      0.46   4.9e+02      40      97 ..     170     226 ..     144     231 .. 0.79
   2 ?   -1.2   0.0       2.1   2.2e+03      30      57 ..     286     313 ..     271     347 .. 0.73
   3 ?    7.0   0.0     0.006       6.3      29      52 ..     676     699 ..     641     704 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.46
                  -SS-HHHHHHHHHHTT----GGGEEEHHHHHHHHHHHHSXXXEEEEESXHHHHHHHHH CS
  Hydrolase_6  40 sskseeeyakkleklgvditeeqvvtsataaaeylkkrkadkkvlvigeeglreelke 97 
                  s+   +e++++l+k gv+ +  +v t +  a  + +k  a++k ++  +e + +e+ke
   EFC39543.1 170 SRDATREIQERLQKYGVEKR-YDVKTIHAFALSICRKYGAKGKTYISTKESIIKEMKE 226
                  34455889999999999865.5677777888888888888999999999999998887 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 2.1
                  T-EEEEEE---SS-HHHHHHHHHHTT-- CS
  Hydrolase_6  30 gkpvvllTNnsskseeeyakkleklgvd 57 
                     +++lT n + s++ y+++ +++ +d
   EFC39543.1 286 REACYILTSNHQGSRDFYQQHYSDVLID 313
                  5578999999999999999888766555 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.006
                  TT-EEEEEE---SS-HHHHHHHHH CS
  Hydrolase_6  29 agkpvvllTNnsskseeeyakkle 52 
                  + k+ ++lTNnss++ ++++++l+
   EFC39543.1 676 RAKEWLYLTNNSSSNSSTFIERLK 699
                  448899***************997 PP

>> PseudoU_synth_2  RNA pseudouridylate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       9.3   9.8e+03     117     132 ..      37      52 ..      17      76 .. 0.62
   2 ?   13.9   0.6     4e-05     0.043      54     131 ..     164     277 ..     163     311 .. 0.72

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 9.3
  PseudoU_synth_2 117 dgkkavtylkvlksgs 132
                      ++k  v+ +k+lks+ 
       EFC39543.1  37 KQKTVVEFFKPLKSKE 52 
                      4455555555555553 PP

  == domain 2  score: 13.9 bits;  conditional E-value: 4e-05
  PseudoU_synth_2  54 llllAksseaanklakafeerkvrKkYlalvf..................................gapeeeegaikkkiskd........... 102
                      lll+++s++a ++ ++ +++++v+K+Y + +                                   +               +           
       EFC39543.1 164 LLLVTFSRDATREIQERLQKYGVEKRYDVKTIhafalsicrkygakgktyistkesiikemkeqleK---------------Knvtltetveky 242
                      79***************************99888888888888666655554444444333333332...............144444445555 PP

  PseudoU_synth_2 103 ......tekqegarrkaeeldgkkavtylkvlksg 131
                             + +e+  ++ +++d k a t+++ +++ 
       EFC39543.1 243 vdwaqdEYAREVSANEFATSDYKAALTIYEEIAKS 277
                      55556677777777888888888888888777765 PP

>> ResIII  Type III restriction enzyme, res subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   1.5   2.6e-05     0.028      22     122 ..     128     231 ..      94     372 .. 0.82
   2 ?   -3.3   0.1       7.6     8e+03      68     110 ..     510     550 ..     504     584 .. 0.51

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 2.6e-05
                 .TTSEEE.EEESTTSTHHHHHHHHHHHH-S.....-EEEEESSHHHHHHHHHHGGGGTGG....GEEEESSS-B--.......-SEEEEEHHHHHHTH. CS
      ResIII  22 krdkrgl.ikmaTGtGKTlvaaklierllkkgkeekflflvprkslleqtleefkkflseaykeigkkvsgdkkkakekdstnkkilvttiqsldadse 119
                 ++  ++l ++++ G GKTlv++  ++++ + +++   l++  +++ +   +e+++k+  e++ +++++      ++ +k   + k +++t +s+ ++++
  EFC39543.1 128 NDSAKYLvVQAPPGGGKTLVLTFRAKKIIETNPNACLLLVTFSRDATREIQERLQKYGVEKRYDVKTIHA-FALSICRKYGAKGKTYISTKESIIKEMK 225
                 5555666599***********************9999999999**************9999987444422.2222224555667777777777777775 PP

                 ...... CS
      ResIII 120 ee...e 122
                 e+   +
  EFC39543.1 226 EQlekK 231
                 553330 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 7.6
                 HHHHHHGGGGTGG....GEEEESSS-B--.......-SEEEEE CS
      ResIII  68 eqtleefkkflseaykeigkkvsgdkkkakekdstnkkilvtt 110
                 e+  e++ ++l+++ +   +kv  ++k + +kd+ +k i ++t
  EFC39543.1 510 EKSFEKYLQYLKDQETPS-TKVPTKGKAP-KKDKLEKFIRFFT 550
                 556666666666665432.2222233333.2344444443333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (705 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1390  (0.077528); expected 358.6 (0.02)
Passed bias filter:                      466  (0.0259914); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.85u 0.34s 00:00:01.19 Elapsed: 00:00:00.58
# Mc/sec: 3668.89
//
Query:       EFC39544.1  [L=496]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.033   14.4   3.2       0.17   12.1   3.2    2.3  1  HALZ      Homeobox associated leucine zipper


Domain annotation for each model (and alignments):
>> HALZ  Homeobox associated leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   3.2   9.6e-06      0.17      20      43 .]     468     491 ..     464     491 .. 0.92

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.6e-06
        HALZ  20 dydsLkkenekLkaelqeLkeklq 43 
                 d+++L+ke ekL++ ++eLk+k q
  EFC39544.1 468 DFNALLKEQEKLLNNIRELKNKIQ 491
                 9********************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2132  (0.118913); expected 358.6 (0.02)
Passed bias filter:                      351  (0.0195772); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.34s 00:00:01.00 Elapsed: 00:00:00.53
# Mc/sec: 2819.41
//
Query:       EFC39545.1  [L=777]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.7e-41  140.9   0.1    4.7e-41  140.9   0.1    2.3  2  Pkinase         Protein kinase domain
    2.5e-32  112.2   0.0    5.6e-32  111.0   0.0    1.6  1  Pkinase_Tyr     Protein tyrosine kinase
    0.00079   18.8   0.0     0.0013   18.1   0.0    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
     0.0012   18.3   0.0     0.0077   15.6   0.0    2.0  1  Kinase-like     Kinase-like
  ------ inclusion threshold ------
      0.042   12.6   0.1      0.042   12.6   0.1    2.7  3  Pkinase_fungal  Fungal protein kinase
       0.22   12.0   3.3        2.2    8.7   2.0    2.7  2  Mvb12           ESCRT-I subunit Mvb12
        6.4    7.8   9.7         41    5.2   0.4    2.8  2  DUF4834         Domain of unknown function (DUF4834)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.6       1.2   3.2e+03     202     242 ..      41      79 ..      26      83 .. 0.58
   2 !  140.9   0.1   1.8e-44   4.7e-41       1     259 [.     376     658 ..     376     661 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.2
                 HHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHH CS
     Pkinase 202 gkekvekeldqlekilkilgetkeklpeaseiseeakdllk 242
                 +++k ++++++  +  ++l+ ++++ p+++++se + +l++
  EFC39545.1  41 DRNKEKSNVQN--NNNNTLKVQQQEHPRRKSFSEMLHNLIT 79 
                 22333333333..3334444556677888888888877775 PP

  == domain 2  score: 140.9 bits;  conditional E-value: 1.8e-44
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE........SSEEEEEEE--TTEBHHHHHH. CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee........kdelylvleyveggeladlle. 90 
                 ye le++G+GsfGkVykav+k+++ +v +Kki+ +++++ ++  +l E   ++k++ p+++ + +++ +          +l+lv+ey++ g+l+++++ 
  EFC39545.1 376 YEILEEVGRGSFGKVYKAVRKSDRVTVGIKKINCDDINNAND--ALVEFWPIRKISYPQLISIQDIYFSksdnefssLFTLCLVMEYMDDGDLEQFINg 472
                 7899*********************************99886..*********************99886777765444678****************9 PP

                 ...HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTEEEE-SGTTSEESSSSCS.....BCTTTSCGGGS-HHHH........... CS
     Pkinase  91 ...rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekgelKitDFGlakelesssk.....ltsfvgtseYlAPEvl........... 169
                    + ++++e+++ +++ q+ +gl++lH +g++HrD+Kp+NiL++ + +e Ki+DFGl  +l+s ++     + s  gt +Y +PE             
  EFC39545.1 473 hkdQGQTIQEAHLLSLMIQMSAGLNHLHLNGLLHRDIKPKNILLSsKFKECKIGDFGLIYNLRSLTSknlndTISSAGTIKYQSPECHigvkditelds 571
                 9977777**************************************56666***********999888899999999**********9668888877765 PP

                 TT........SCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 170 ke........neyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                 ke         +y  ++D+Ws+G++++el  g+++++    +  + + +++ +++        +  ++ s+  e + +l+ ++l+ +pk+R+  e+l+
  EFC39545.1 572 KEpiaptslfMNYIYSSDIWSMGIVFLEL-VGCEILN---FSP-YIMAMKDQQQFHG------LIRKRCSKYHEGFANLIISMLSLEPKDRPDSEKLV 658
                 1156666677899***************9.6777777...233.3333333233333......345789999********************998877 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.0   0.0   2.2e-35   5.6e-32       3     259 .]     378     661 ..     376     661 .. 0.83

  Alignments for each domain:
  == domain 1  score: 111.0 bits;  conditional E-value: 2.2e-35
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE.SSSS.......EEEEEE--TTEBHHHHH CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct.keep.......llivteyvkgGdLlkfL 92 
                  + +++G+G+fGkV+++  k    +++v+V +K+++ +  ++  ++ l e   ++k++ p+++++  ++  k+++       l++v+ey++ GdL++f+
   EFC39545.1 378 ILEEVGRGSFGKVYKAVRK----SDRVTVGIKKINCDDINN-ANDALVEFWPIRKISYPQLISIQDIYFsKSDNefsslftLCLVMEYMDDGDLEQFI 470
                  6799*************99....999********8877766.7888889999***************99533336889999***************** PP

                  HHT..CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEET.TEEEE-STTTHEET..TTSSEEEETTSSTSGGGGS-HHHHHHSE.... CS
  Pkinase_Tyr  93 rkk..ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsen.kvvkisDfGLardi..ekddeyvkkeeaklpvkWmapEslkekk.... 181
                  + +  + ++++  +lls+++q+++G+++L+ + l+Hrd+  +N+Lls++ k +ki+DfGL  ++   ++++ +++ ++   +k+ +pE+    k    
   EFC39545.1 471 NGHkdQGQTIQEAHLLSLMIQMSAGLNHLHLNGLLHRDIKPKNILLSSKfKECKIGDFGLIYNLrsLTSKNLNDTISSAGTIKYQSPECHIGVKdite 568
                  98833566778889********************************986269********99984334556688889999*********887777889 PP

                  ...............EEHHHHHHHHHHHHHHHHTTSS...GTTTTS.HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr 182 ...............ftsksDvWsfGvllwEiftlge...spypgl.kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselvekl 259
                                 +  +sD+Ws G++  E++       spy    k++   ++  +g   ++ +k +e +++l+ + ++ +p++Rp+ ++lv++l
   EFC39545.1 569 ldskepiaptslfmnYIYSSDIWSMGIVFLELVGCEIlnfSPYIMAmKDQ---QQ-FHGLIRKRCSKYHEGFANLIISMLSLEPKDRPDSEKLVRTL 661
                  99************999***************974432124553331222...33.333334445567889999999************99999876 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   5.1e-07    0.0013      58     160 ..     418     522 ..     379     531 .. 0.83

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 5.1e-07
         Kdo  58 avrEfrllkrLeeagvavpkpvaagavkvgle..yrAlllterlegaqdLedllakwaelaeelkrall....kavgrliaklhragvnHadlyaknil 150
                 a  Ef  +++    ++  ++ +++     ++   ++  l++e +++  dLe++++ +++ +++ ++a+l     +  +  + lh  g+ H+d+ +knil
  EFC39545.1 418 ALVEFWPIRKISYPQLISIQDIYFSKSDNEFSslFTLCLVMEYMDD-GDLEQFINGHKDQGQTIQEAHLlslmIQMSAGLNHLHLNGLLHRDIKPKNIL 515
                 56788888888999999999999999999888888999******98.69******99998888888765221157888899****************** PP

         Kdo 151 lqqeeeeeae 160
                 l  +     e
  EFC39545.1 516 LSSKF---KE 522
                 *9998...33 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0     3e-06    0.0077     147     288 .]     484     651 ..     442     651 .. 0.65

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 3e-06
  Kinase-like 147 lllTlqlirlaa...nLqakglvhgkftvdnllldekgg.lmlggftaLvrag..tkvvlseve.....kgfaPpEll.gsrgg..ytrknk...... 224
                  +ll l +i++ a   +L+ +gl+h +++++n+ll  k++  ++g+f+ ++     t+  l+ +        ++ pE   g +       k+       
   EFC39545.1 484 HLLSL-MIQMSAglnHLHLNGLLHRDIKPKNILLSSKFKeCKIGDFGLIYNLRslTSKNLNDTIssagtIKYQSPECHiGVKDIteLDSKEPiaptsl 580
                  33444.55555511167779*****************96489****9988554114444544445666655677765414443334344433111112 PP

  Kinase-like 225 .tkmthkldaWqlGlviyr.iwclklPltlateeakeew.....kfklckkipekvkaLlkkfLqlsqedR 288
                   +++ ++ d W +G+v +  + c  l +      +k +      + k+c k  e  + L++ +L l+ +dR
   EFC39545.1 581 fMNYIYSSDIWSMGIVFLElVGCEILNFSPYIMAMKDQQqfhglIRKRCSKYHEGFANLIISMLSLEPKDR 651
                  256778999******99972568888777666555555433566778999999999999999999988887 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   2.0      0.58   1.5e+03     249     277 ..      27      60 ..       7      91 .. 0.39
   2 ?   12.6   0.1   1.6e-05     0.042     300     346 ..     481     522 ..     473     559 .. 0.74
   3 ?   -0.1   0.4      0.12   3.1e+02     260     295 ..     704     741 ..     637     771 .. 0.48

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.58
  Pkinase_fungal 249 sskaevklkksesskkvekrsvdssv......sts 277
                     ++++++++++++s+++ +k++++ ++      + +
      EFC39545.1  27 PPQSSSDSNNNNSNDR-NKEKSNVQNnnnntlKVQ 60 
                     2222222222222111.111111111011112222 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 1.6e-05
  Pkinase_fungal 300 ekaespkellealrDaIkghrsLflkagiLHrDiSenNilitdskke 346
                     ++     +ll+ +++  +g++ L+   g+LHrDi  +Nil+  + ke
      EFC39545.1 481 QE----AHLLSLMIQMSAGLNHLH-LNGLLHRDIKPKNILLSSKFKE 522
                     44....35888888889999****.99**************966333 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.12
  Pkinase_fungal 260 esskkvekrsvdssv..stskrsrlenrvhrrlvispv 295
                     +  +++++++ dss+  s+s++s+ + r+++   ++++
      EFC39545.1 704 SKDDHRSQHQQDSSTssSESEKSNNNRRTLSLHSVKDF 741
                     11111111222222222333333333344444444444 PP

>> Mvb12  ESCRT-I subunit Mvb12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   2.0   0.00087       2.2       8      59 ..      43      94 ..      38     101 .. 0.86
   2 ?    1.2   0.0      0.19     5e+02      26      48 ..     236     258 ..     209     269 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00087
                ESSSTTS------------------HHHHHHHHHHHHHHHHHHHHHHHHHTH CS
       Mvb12  8 nklgedfPkeklsklevpelkleelqptkemlepwykecdelvealekhdks 59
                nk  +++ +++ + l+v++ + +++++ +eml+  ++e+d+l+++  +h ++
  EFC39545.1 43 NKEKSNVQNNNNNTLKVQQQEHPRRKSFSEMLHNLITENDNLISDKYNHSDE 94
                777788888999*****************************99877666544 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.19
                 -------HHHHHHHHHHHHHHHH CS
       Mvb12  26 elkleelqptkemlepwykecde 48 
                 +++l+++ +t+eml+ ++ +c+ 
  EFC39545.1 236 AMQLDNISATSEMLHNYIMKCKP 258
                 468899999**********9985 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   3.4     0.016        42      28      85 ..       8      70 ..       3      74 .. 0.38
   2 ?    5.2   0.4     0.016        41      24      73 ..     682     730 ..     672     744 .. 0.50

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.016
     DUF4834 28 tvfglgsrkkss.........ksaqkqfgnstnsnqqksqsrsetkeegeiieeersekeakrkkiF 85
                +++gl + ++ s         +s +   +n++nsn +++++++ +++++++ + +++e+  +r+k F
  EFC39545.1  8 SFMGLDKSSSTSsptptttppQSSS--DSNNNNSNDRNKEKSNVQNNNNNTLKVQQQEH--PRRKSF 70
                5555444444334555444332222..22222222222222233333333333333333..455666 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.016
     DUF4834  24 vilrtvfglgsrkkss..ksaqkqfgnstnsnqqksqsrsetkeegeiieee 73 
                  i r+++++g+  k+        + ++  +++q++++s+++++e++++++++
  EFC39545.1 682 EIHRQLLSVGKSVKGIflG---TKDSKDDHRSQHQQDSSTSSSESEKSNNNR 730
                 5667777766666666221...222222233333333333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (777 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1627  (0.0907468); expected 358.6 (0.02)
Passed bias filter:                      588  (0.032796); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.83u 0.35s 00:00:01.18 Elapsed: 00:00:00.52
# Mc/sec: 4461.27
//
Query:       EFC39546.1  [L=253]
Description: hypothetical protein NAEGRDRAFT_81289 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.011   15.7   0.1       0.02   14.9   0.1    1.4  1  tRNA_anti-codon  OB-fold nucleic acid binding domain


Domain annotation for each model (and alignments):
>> tRNA_anti-codon  OB-fold nucleic acid binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.9   0.1   1.1e-06      0.02       1      62 [.      73     138 ..      73     166 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.1e-06
                      EEEEEEEEEEEEEEETTEEEEEEEETTEEEEEEEET....HHHHHHHTTS-TTSEEEEEEEEEECT CS
  tRNA_anti-codon   1 VtvaGrvtsisdrsggkvifidlrDgtgriqvvlfr....eeatklaenlkeGdvvrvtGrvkrrp 62 
                      Vt+++ +++     +++ +++ l+Dgtgr+ v+l      +++++    +++G ++r++G ++ ++
       EFC39546.1  73 VTLVAQIVKFTNEPEKRKLNLFLDDGTGRMSVILYAidteKKFEACGGVIENGLFLRIYGILNIDN 138
                      77888888888788899999*******************999******************998874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.29s 00:00:00.80 Elapsed: 00:00:00.45
# Mc/sec: 1675.83
//
Query:       EFC39547.1  [L=221]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.2e-12   48.4   0.4    1.2e-12   48.4   0.4    2.6  2  CDP-OH_P_transf  CDP-alcohol phosphatidyltransferase


Domain annotation for each model (and alignments):
>> CDP-OH_P_transf  CDP-alcohol phosphatidyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.4   0.4   6.9e-17   1.2e-12       2      66 .]      20      82 ..      19      82 .. 0.86
   2 ?   -3.9   6.2         1   1.8e+04      27      35 ..     149     163 ..      84     203 .. 0.60

  Alignments for each domain:
  == domain 1  score: 48.4 bits;  conditional E-value: 6.9e-17
                     -HHHHHHHHHHHHHHHHHGGGS-H..HHHHHHHHHHHHHTTHHHHHHHHTT---HHHHHHHHHHH CS
  CDP-OH_P_transf  2 lPnaiTllrlllsvlailllltyyplvlailllliasltDalDGklARrlnqvstlGkllDslaD 66
                     +Pn+i +lr++ls+l+++ ++ +yp  + i+++  ++++D+lDG  AR +nq s++G++lD + D
       EFC39547.1 20 IPNLIGYLRVFLSLLSFF-IYESYP-GTVIVIYTTSFVLDGLDGIAARHYNQCSRFGAVLDMVTD 82
                     8****************6.545554.4555556799****************999*******998 PP

  == domain 2  score: -3.9 bits;  conditional E-value: 1
                      .HHHHHHH......H CS
  CDP-OH_P_transf  27 lvlailll......l 35 
                      +++ail++      +
       EFC39547.1 149 TFMAILCVgnelfyV 163
                      444444433332220 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (221 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       580  (0.0323498); expected 358.6 (0.02)
Passed bias filter:                      233  (0.0129957); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.30s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 1339.03
//
Query:       EFC39548.1  [L=717]
Description: hypothetical protein NAEGRDRAFT_81290 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (717 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1391  (0.0775838); expected 358.6 (0.02)
Passed bias filter:                      449  (0.0250432); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.77u 0.36s 00:00:01.12 Elapsed: 00:00:00.55
# Mc/sec: 3907.43
//
Query:       EFC39549.1  [L=163]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
       0.11   12.7   0.2       0.22   11.7   0.2    1.5  1  CRISPR_Cas2  CRISPR associated protein Cas2


Domain annotation for each model (and alignments):
>> CRISPR_Cas2  CRISPR associated protein Cas2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.2   1.2e-05      0.22      33      61 ..      46      73 ..      34      79 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 1.2e-05
                 TTEEEEEESHHHHHHHHHHHHHHSHTTTC CS
  CRISPR_Cas2 33 ySVFegelseaqleklkkrlkkiidpeed 61
                  SVFe el+++q+++l k l++ ++++ d
   EFC39549.1 46 VSVFEFELTDKQAKDLPKILRQQKNEN-D 73
                 5**********************9987.5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (163 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1071  (0.0597356); expected 358.6 (0.02)
Passed bias filter:                      634  (0.0353617); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.33s 00:00:00.84 Elapsed: 00:00:00.51
# Mc/sec: 970.19
//
Query:       EFC39550.1  [L=378]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-09   38.6   0.0      0.011   16.3   0.0    3.6  3  RCC1      Regulator of chromosome condensation (RCC1) repeat
    6.5e-05   22.6   3.1        3.4    7.6   0.1    3.7  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.0   1.7e-05      0.15       2      22 ..       9      30 ..       9      55 .. 0.81
   2 !    5.3   0.0    0.0033        30      37      50 .]     101     114 ..      72     114 .. 0.85
   3 !   16.3   0.0   1.2e-06     0.011       3      49 ..     292     341 ..     290     342 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.7e-05
                TEEEEEE--GGGTTSSSS-.-- CS
        RCC1  2 GrVysWGrndyGqLGlgtt.es 22
                G+++s+G n++Gq+ + ++ ++
  EFC39550.1  9 GELFSFGGNSKGQCACSSKaKN 30
                99************99888533 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0033
                 EEEEEEETTEEEEE CS
        RCC1  37 vvkvacGddhtval 50 
                 v   acG +h+v++
  EFC39550.1 101 VNEFACGRNHSVLI 114
                 6678*******986 PP

  == domain 3  score: 16.3 bits;  conditional E-value: 1.2e-06
                 EEEEEE--GGGTTSSSS-..--EEEEEE-.GGGTTS-EEEEEEETTEEEE CS
        RCC1   3 rVysWGrndyGqLGlgtt..esvlvPtkv.eglsgnrvvkvacGddhtva 49 
                 ++y++G n+++qLGl+    +s++v   + e+l++ ++++v  G+ ++++
  EFC39550.1 292 KIYCCGANQNNQLGLKEPkyNSSTVHEYLsELLERFNFIDVKYGHGFSLV 341
                 69*************77766444333333255554499999999999986 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.1   0.00038       3.4      18      30 .]       9      21 ..       8      21 .. 0.97
   2 !    6.9   0.0   0.00061       5.4       5      19 ..     105     119 ..     101     124 .. 0.90
   3 !    5.9   0.5    0.0012        11      17      30 .]     290     303 ..     288     303 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00038
      RCC1_2 18 GeVlcWGsNsdGQ 30
                Ge++++G Ns GQ
  EFC39550.1  9 GELFSFGGNSKGQ 21
                89**********9 PP

  == domain 2  score: 6.9 bits;  conditional E-value: 0.00061
      RCC1_2   5 saGdyHscaLtedGe 19 
                 ++G++Hs+ + +d++
  EFC39550.1 105 ACGRNHSVLICNDWK 119
                 8**********9975 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.0012
      RCC1_2  17 dGeVlcWGsNsdGQ 30 
                 +++++c+G N + Q
  EFC39550.1 290 NNKIYCCGANQNNQ 303
                 899******99987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (378 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1561  (0.0870656); expected 358.6 (0.02)
Passed bias filter:                      535  (0.0298399); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 2093.73
//
Query:       EFC39551.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
      0.011   15.9   0.7      0.011   15.9   0.7    2.4  2  ATPase_gene1  Putative F0F1-ATPase subunit Ca2+/Mg2+ transpor
      0.014   15.2   3.5      0.014   15.2   3.5    1.6  1  Imp-YgjV      Bacterial inner membrane protein
      0.058   13.6   0.7      0.058   13.6   0.7    1.6  2  DUF2534       Protein of unknown function (DUF2534)


Domain annotation for each model (and alignments):
>> ATPase_gene1  Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.9   0.7   1.8e-06     0.011      29      51 ..      82     105 ..      67     107 .. 0.94
   2 ?    0.5   1.0      0.11   6.8e+02       3      24 ..     113     134 ..     111     152 .. 0.75

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.8e-06
  ATPase_gene1  29 fgt.spwfliiglllGlaaGfynv 51 
                   f+t +p++ ++++++G+a Gfy++
    EFC39551.1  82 FNTsQPVWILLLSMAGVACGFYSM 105
                   8899******************97 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.11
  ATPase_gene1   3 lasqiGielvapillggllGyw 24 
                   +++   +++va++  +++lG +
    EFC39551.1 113 MFMYSLVNFVAFVHSCFYLGPF 134
                   6666667899999999999955 PP

>> Imp-YgjV  Bacterial inner membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   3.5   2.4e-06     0.014       5      74 ..      92     161 ..      88     164 .. 0.92

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 2.4e-06
    Imp-YgjV   5 iigllalllgilsfqqkddrrllllqlvsnllfalhfalLgaytaalsnllsavRtllslktrkkkvmll 74 
                 +++++++++g++s+  +d   +++++lv  ++f+ + + Lg  +++   +l+++  +l l  + k v ++
  EFC39551.1  92 LLSMAGVACGFYSMATRDPLGMFMYSLVNFVAFVHSCFYLGPFAGTSHLILNSMSFVLLLLNQIKSVGYV 161
                 57899**************************************************999998877777666 PP

>> DUF2534  Protein of unknown function (DUF2534)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.7   9.8e-06     0.058      36      78 ..      51      94 ..      42      96 .. 0.84
   2 ?   -3.3   0.2       1.8   1.1e+04      59      63 ..     115     119 ..     110     131 .. 0.53

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 9.8e-06
     DUF2534 36 dqYnlPlseWt.tsmfliqgamvavYslvftvllsiPlafyfLg 78
                +qYn P +    + mf  q ++++v s+ f + +s P++++ L+
  EFC39551.1 51 KQYNRPANLANlANMFSFQLFLIFVLSVLFLFNTSQPVWILLLS 94
                58999987554268*************************99885 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.8
     DUF2534  59 vYslv 63 
                 +Yslv
  EFC39551.1 115 MYSLV 119
                 44444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       892  (0.0497518); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.33s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1045.72
//
Query:       EFC39552.1  [L=375]
Description: tartrate resistant acid phosphatase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.1e-14   53.3   1.4    7.3e-14   52.7   1.4    1.2  1  Metallophos  Calcineurin-like phosphoesterase


Domain annotation for each model (and alignments):
>> Metallophos  Calcineurin-like phosphoesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.7   1.4   4.1e-18   7.3e-14       1     203 [.      91     305 ..      91     306 .. 0.68

  Alignments for each domain:
  == domain 1  score: 52.7 bits;  conditional E-value: 4.1e-18
                  EEEEEEESBTBTTCCTHHHHHHHHHHHHHHHTTESEEEEESTSSSSSHHHHHHHHH.HHHHHHH........TSEEEEEC-TTSCHHHHHHHHHHHHH CS
  Metallophos   1 lrilvigDlHlalgggqlddllkllddllreekpdlvllaGDlvdrgdlekellel.laalvky........pipvylllGNHegfeeellnkygylg 89 
                  lr+lv+gD++  +++ +  ++++ + ++ + +k+ +v+  GD+++  ++e+ +++  ++ +++         + ++++llGNH+ ++ +++ + +y +
   EFC39552.1  91 LRFLVVGDMG--RADDGQKAVAASMGKFCKTQKCHFVIGIGDNIYNYGVEN-VNDEqFKSKFEDiynvdgieDLKWHMLLGNHD-YRGNVQAQIDYTK 184
                  69********..88888888888888888888******99**888887777.66664555555577889999************.4445555555544 PP

                  HHHHHHEHHHCEEETSEEEEEETTEEEEEEEESECEEE....THHHHHHHHHHHSCHHHHCCHHHHHH...HHHHTTCSEEEEEESSESSCSSSCSCC CS
  Metallophos  90 ifsepwrsdaevfnnlplaslgsgslkvlllhGgspel....lvsldklgslnleleapepgdewlkd...lekrekadwvivlgHsplyrgsgylfg 180
                  i s+ w  ++ ++  +  + l +   +v  +  ++ ++    ++ l+k  +l+ +   ++++ ++l     + + +++ w++v+gH+ +y ++g   +
   EFC39552.1 185 I-SNRWVLPSHFYTLVKNSTLSGF--DVSMVMLDTSPFvsfwTDPLMKSSNLESQYKRKQEQLDMLDGvlsTNQGKNNSWTLVFGHHHIY-SGGIGGN 278
                  4.5555555333333333332222..3333333333333344444444444444444444444444445555999***************.7777777 PP

                  HHHHH....HHHHHTTESEEEEESSSS CS
  Metallophos 181 deale....dllkkygvdlvisGHtHv 203
                  ++ ++    ++ +ky+v l+ +GH+H 
   EFC39552.1 279 SKDMMntflPYMEKYQVPLYTCGHVHL 305
                  777777999*****************5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (375 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       724  (0.0403815); expected 358.6 (0.02)
Passed bias filter:                      557  (0.031067); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 2449.80
//
Query:       EFC39553.1  [L=893]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.4e-70  237.2  12.8    2.4e-70  237.2  12.8    2.3  3  E3_UFM1_ligase  E3 UFM1-protein ligase 1


Domain annotation for each model (and alignments):
>> E3_UFM1_ligase  E3 UFM1-protein ligase 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  237.2  12.8   1.4e-74   2.4e-70       2     266 ..      11     305 ..      10     310 .. 0.96
   2 ?   -3.0   0.1      0.25   4.5e+03     136     158 ..     404     426 ..     391     439 .. 0.63
   3 ?   -3.0   0.6      0.24   4.3e+03      15     208 ..     547     564 ..     531     598 .. 0.52

  Alignments for each domain:
  == domain 1  score: 237.2 bits;  conditional E-value: 1.4e-74
  E3_UFM1_ligase   2 ieeLqaqlqsaQeaks...sqkLSernvieivnkliekkll...dlihtldGkeYlTpeqLekeikdelekagGRvnlvdLakilnvdlshiekk 90 
                     ie+Lq+q++++Q+++    s+kL+e+n+ie+++++++++     +l++t+dGkeY+T++q+e e++  lek gGR+n ++L+k+l+vd++++e+ 
      EFC39553.1  11 IEQLQQQFEQVQQESLsggSYKLNEHNIIELIQYIKKQDPNfaeQLCFTSDGKEYITRDQIEYELQILLEKYGGRINKNELPKLLRVDFTYLEQP 105
                     99************9877789*****************99999**************************************************** PP

  E3_UFM1_ligase  91 aeeivkedke.lqlvqg.elitksYldsiaeeineklqeagqvsiaelakqydlpvdflke.llekrlgkiikgrld.gevlyTeafvarqkakv 181
                     ++++++++    +l++g e++t sYl+s+++eine l+ +g + i++l+kq+ lp+df+ke +++k+++ +++g +  +++lyTe+++++ k++ 
      EFC39553.1 106 IHNLIQKQIVlPDLINGcEILTPSYLESVVMEINELLKLSGYIYIGTLTKQLFLPSDFIKEhIITKYMHLLLNGTIFsNNSLYTEKYINNLKSIT 200
                     ********9989*************************************************99999999999998866***************** PP

  E3_UFM1_ligase 182 rGalsaitkptll.ssllkk..................veleekllqslleeLikekeikGslkagrelyiPtiyskaqeewvesfykqngyiey 257
                     +G++++it++ +  ++llk                   +e+e +l+q+++++Lik+k+i+G+l+ +++ly+P+iy+k+ +++v++f+++ngy+++
      EFC39553.1 201 IGICNSITSRSMEcNDLLKVtkkfylmnesngneyaddIEIELELYQNIVKDLIKNKQINGTLQVNSTLYVPNIYEKMATDQVCKFIHSNGYVSV 295
                     ********987655999999999************************************************************************ PP

  E3_UFM1_ligase 258 dalkk.lgis 266
                     +++++ lg++
      EFC39553.1 296 ERVESmLGYK 305
                     ***9967665 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.25
  E3_UFM1_ligase 136 lakqydlpvdflkellekrlgki 158
                     + ++y ++v+++ ++l+++ ++i
      EFC39553.1 404 FDNRYIMTVEMIDQILNDQFKSI 426
                     45667777777777777666543 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 0.24
  E3_UFM1_ligase  15 akssqkLSernvieivnkliekklldlihtldGkeYlTpeqLekeikdelekagGRvnlvdLakilnvdlshiekkaeeivkedkelqlvqgeli 109
                      k +qkLS                                                                                       
      EFC39553.1 547 MKLEQKLSSEL------------------------------------------------------------------------------------ 557
                     33333333222.................................................................................... PP

  E3_UFM1_ligase 110 tksYldsiaeeineklqeagqvsiaelakqydlpvdflkellekrlgkiikgrldgevlyTeafvarqkakvrGalsaitkptllssllkkvele 204
                                                                                                                 ++e
      EFC39553.1 558 --------------------------------------------------------------------------------------------NVE 560
                     ............................................................................................222 PP

  E3_UFM1_ligase 205 ekll 208
                     ekl 
      EFC39553.1 561 EKLN 564
                     2222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (893 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2089  (0.116515); expected 358.6 (0.02)
Passed bias filter:                      385  (0.0214736); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.92u 0.34s 00:00:01.26 Elapsed: 00:00:00.58
# Mc/sec: 4652.33
//
Query:       EFC39554.1  [L=756]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (756 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1575  (0.0878465); expected 358.6 (0.02)
Passed bias filter:                      233  (0.0129957); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 1.03u 0.38s 00:00:01.41 Elapsed: 00:00:00.60
# Mc/sec: 3786.19
//
Query:       EFC39555.1  [L=430]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.9e-09   36.5   0.1    0.00027   20.8   0.0    3.0  2  NHL           NHL repeat
      6e-06   26.5  68.7      0.015   15.6  13.1    5.3  5  EGF_2         EGF-like domain
    5.6e-05   22.8   0.0    9.6e-05   22.0   0.0    1.3  1  Ras           Ras family
    5.7e-05   23.3  52.5     0.0013   19.0  10.5    5.0  4  EGF           EGF-like domain
  ------ inclusion threshold ------
      0.023   15.3  26.2      0.031   14.9   9.1    5.9  7  hEGF          Human growth factor-like EGF
       0.14   12.3   0.1       0.68   10.2   0.0    2.1  2  Arylesterase  Arylesterase


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.0     4e-05      0.12       1      23 [.      52      74 ..      52      78 .. 0.88
   2 !   20.8   0.0   9.2e-08   0.00027       1      27 [.     109     136 ..     109     137 .. 0.91

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4e-05
                BSSEEEEEEETTTEEEEEECCCT CS
         NHL  1 fnyPhGvavdsnGdiyVaDsenh 23
                f+ P Gva+  nG+++++D++n+
  EFC39555.1 52 FRIPYGVALGMNGELFITDTNNN 74
                67788****************98 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 9.2e-08
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +++P G++vd  nG iyV+D++n+rv++
  EFC39555.1 109 LSSPYGIVVDqLNGTIYVCDFGNSRVRK 136
                 56788*********************97 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.9         3   8.9e+03      11      15 ..     148     152 ..     141     157 .. 0.70
   2 !   14.1   8.1   1.5e-05     0.045       7      30 ..     166     188 ..     163     189 .. 0.90
   3 !   15.5  11.7   5.4e-06     0.016       1      28 [.     196     221 ..     196     224 .. 0.82
   4 !   15.6  13.1   5.1e-06     0.015       6      30 ..     235     258 ..     231     259 .. 0.81
   5 !    5.6   4.3     0.007        21       1      16 [.     266     280 ..     260     284 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 3
       EGF_2  11 hGtCv 15 
                 +G Cv
  EFC39555.1 148 NGNCV 152
                 78887 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 1.5e-05
       EGF_2   7 iCgghGtCvnqcGqCdCdsgyqGk 30 
                  C+ghG C +++  C C+ g+ G 
  EFC39555.1 166 VCSGHGNCQSSN-HCNCQEGWNGS 188
                 5*******9777.8*******996 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 5.4e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyq 28 
                 C++   +C+g+G+C++ +  C+C+sg+ 
  EFC39555.1 196 CESI-GNCNGNGKCISNN-TCECQSGWN 221
                 7664.67*******9555.9*******6 PP

  == domain 4  score: 15.6 bits;  conditional E-value: 5.1e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGk 30 
                 ++C+g+G+C+ ++  C+C+sg+ G+
  EFC39555.1 235 NNCNGNGQCI-SNSTCECQSGWRGN 258
                 68*******8.4558********97 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.007
       EGF_2   1 CsasdeiCgghGtCvn 16 
                 C a  ++C+g+G+C++
  EFC39555.1 266 CDAL-SQCNGNGKCIS 280
                 4443.68*******84 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0   3.2e-08   9.6e-05      55     157 ..     285     409 ..     266     413 .. 0.82

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 3.2e-08
                 ETTSGGGHHHHHHHHTTESEEEEEEETTBH....HHHHTHH.HHHHHHHHHSTTTSEEEEEEETTTGGG..................G-SS-HHHHHHH CS
         Ras  55 TAGqeefkslrelyyrdaegillvyditsr....esfenvk.kwveeikrvaeenvpivLvGnKvDlee..................kravsteegeel 130
                 T Gqee + l     ++++ ++++y+i+s     + +e+ + +++ ei++  + n ++++vG+K+D+ +                  k     + g++l
  EFC39555.1 285 TPGQEELRPLSYDKPSKCHIFIMCYAISSPvmmiKCLEDFSdRFLPEIQSFLDYNRSVLVVGTKSDICDysktgdfrlgkywnsylcK--KYDSYGKKL 381
                 89*************************9983333566777778999*******99**************9999999999999865322..234568999 PP

                 HHHHT.SEEEEEBTTTTCTHHHHHHHHH CS
         Ras 131 akelg.lkfletSAktnenveeafeell 157
                 ++ +g + ++ tS ++  ++ee+ + ++
  EFC39555.1 382 SQWMGaVSYVTTSSREFVGLEELEDLIV 409
                 9999989999999999888887655555 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   5.8   0.00092       2.7       6      31 ..     167     188 ..     156     189 .. 0.81
   2 !    9.9   9.9    0.0003       0.9       1      28 [.     196     220 ..     196     222 .. 0.93
   3 !   19.0  10.5   4.3e-07    0.0013       1      31 [.     231     258 ..     231     259 .. 0.95
   4 ?    3.4   2.6     0.032        96       1      15 [.     266     281 ..     266     285 .. 0.72

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00092
                 STTT-EEEEETTTEEEEEECTTEEST CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytGk 31 
                 Cs++G C      + +C C+eG+ G+
  EFC39555.1 167 CSGHGNCQ----SSNHCNCQEGWNGS 188
                 *******5....555*********96 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0003
                 GCS.TTSTTT-EEEEETTTEEEEEECTTE CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGy 28 
                 C + ++C+++G+C+++     tC+C++G+
  EFC39555.1 196 CESiGNCNGNGKCISNN----TCECQSGW 220
                 88889********9999....*******9 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 4.3e-07
                 GCS.TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF   1 Csp.npCsngGtCvdtgrggytCiCpeGytGk 31 
                 C++ n+C+++G C++++    tC+C++G+ G+
  EFC39555.1 231 CNDlNNCNGNGQCISNS----TCECQSGWRGN 258
                 ***888***********....*********97 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.032
                 GCS.TTSTTT-EEEEE CS
         EGF   1 Csp.npCsngGtCvdt 15 
                 C+    C+++G+C+++
  EFC39555.1 266 CDAlSQCNGNGKCISN 281
                 566456*******764 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.1       2.1   6.2e+03       8      17 ..     117     128 ..     114     128 .. 0.74
   2 ?   -3.3   0.5       5.6   1.7e+04       3      16 ..     148     156 ..     147     156 .. 0.60
   3 ?    4.3   9.9     0.023        68       1      22 []     167     185 ..     167     185 .. 0.96
   4 ?   14.2   9.1   1.7e-05      0.05       1      22 []     202     220 ..     202     220 .. 0.91
   5 ?   14.9   9.1     1e-05     0.031       1      22 []     237     255 ..     237     255 .. 0.98
   6 ?    4.1   3.5     0.026        79       1      12 [.     272     282 ..     272     285 .. 0.76
   7 ?   -3.3   0.0       5.6   1.7e+04      12      16 ..     367     371 ..     366     372 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.1
                 S..-SS...-EE CS
        hEGF   8 idgvgg..ykCi 17 
                 +d+ +g  y+C+
  EFC39555.1 117 VDQLNGtiYVCD 128
                 577788889996 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 5.6
                 TT-EES..-SS.-E CS
        hEGF   3 ngGtCidgvggykC 16 
                 n G C+     ++C
  EFC39555.1 148 N-GNCV----YPVC 156
                 3.4788....5666 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.023
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 C+++G C+    ++ C C  G+
  EFC39555.1 167 CSGHGNCQ---SSNHCNCQEGW 185
                 ********...8899******* PP

  == domain 4  score: 14.2 bits;  conditional E-value: 1.7e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G Ci    +++C+C +G+
  EFC39555.1 202 CNGNGKCI---SNNTCECQSGW 220
                 ********...446******** PP

  == domain 5  score: 14.9 bits;  conditional E-value: 1e-05
                 --TT-EES..-SS.-EE--TTX CS
        hEGF   1 CnngGtCidgvggykCiCpPGy 22 
                 Cn++G+Ci   ++ +C+C +G+
  EFC39555.1 237 CNGNGQCI--SNS-TCECQSGW 255
                 ********..999.******** PP

  == domain 6  score: 4.1 bits;  conditional E-value: 0.026
                 --TT-EES..-S CS
        hEGF   1 CnngGtCidgvg 12 
                 Cn++G Ci   +
  EFC39555.1 272 CNGNGKCI-SNN 282
                 ********.444 PP

  == domain 7  score: -3.3 bits;  conditional E-value: 5.6
                 SS.-E CS
        hEGF  12 ggykC 16 
                 ++y C
  EFC39555.1 367 NSYLC 371
                 89999 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.55   1.6e+03      37      76 ..      36      74 ..      11      82 .. 0.76
   2 ?   10.2   0.0   0.00023      0.68      41      73 ..      97     129 ..      58     137 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.55
  Arylesterase 37 avvYyspsevkvvasglssanGInidadkkyiyvadilre 76
                  + + ys++     a+++  + G+ +  +   ++++d  ++
    EFC39555.1 36 NQIAYSGDGGLAIAASFRIPYGVALGMNGE-LFITDTNNN 74
                  456688888888899999999998877654.677776555 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00023
  Arylesterase  41 yspsevkvvasglssanGInidadkkyiyvadi 73 
                   ys++     a++lss+ GI++d+ +  iyv d 
    EFC39555.1  97 YSGDGGLAIAAKLSSPYGIVVDQLNGTIYVCDF 129
                   7777888899********************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (430 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       598  (0.0333538); expected 358.6 (0.02)
Passed bias filter:                      222  (0.0123822); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.56
# Mc/sec: 2303.16
//
Query:       EFC39556.1  [L=220]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.7e-67  224.4   2.7    9.5e-67  224.0   2.7    1.1  1  DPCD            DPCD protein family
  ------ inclusion threshold ------
       0.91   10.1   5.7        2.2    8.9   0.7    2.7  3  Pih1_fungal_CS  Fungal Pih1 CS domain
        4.8    8.2   7.7       0.93   10.5   1.3    2.6  2  Lipocalin_4     Lipocalin-like domain


Domain annotation for each model (and alignments):
>> DPCD  DPCD protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  224.0   2.7   1.6e-70   9.5e-67       8     188 ..      29     207 ..      24     209 .. 0.96

  Alignments for each domain:
  == domain 1  score: 224.0 bits;  conditional E-value: 1.6e-70
        DPCD   8 akktsliqdgkrkvhykfedgkemvEEYdvktdellvRkwrkksklgkekeWevevGeeekkanaaseeelikesssnPilvrkdtkksfqwRiRNlpY 106
                   +ts+++dg+rk+h+++e+g emvEE+d++t++ll+Rk+r+ s lg e++W++e+G e k++n    ++li+ s+ nPi++rkdt++ fqwR+RN+ Y
  EFC39556.1  29 PYTTSVVADGRRKFHTTYENGVEMVEEFDLQTNQLLLRKRRTVSILG-EGTWTIEIGGEVKSFNP--IHDLIAPSTVNPIFMRKDTSTLFQWRVRNCFY 124
                 6789****************************************995.677***********999..99****************************** PP

        DPCD 107 pkevysvtvdeeereivvrTtNkKYyKklsipdldrl.klkleqealsfahanntLiisYkKPkeileaekellkelkklkak 188
                 + +vy+v++d+e++eiv+ TtNkKYyK++sipd++++ k+kl++e+lsf+ +nntLiisY KP+ il++e++ ++el+++k++
  EFC39556.1 125 EPNVYKVNIDHEKQEIVISTTNKKYYKRFSIPDMKESpKTKLNDESLSFKLENNTLIISYVKPDLILKKERAKEMELASMKSE 207
                 **********************************99879*****************************************987 PP

>> Pih1_fungal_CS  Fungal Pih1 CS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       0.7   4.2e+03      35      50 ..      54      69 ..      41      74 .. 0.73
   2 ?    8.9   0.7   0.00037       2.2      23      56 ..     119     152 ..     104     160 .. 0.76
   3 ?    2.8   0.1     0.028   1.7e+02      29      53 ..     165     189 ..     157     202 .. 0.77

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 0.7
  Pih1_fungal_CS 35 vsYdakeneLiiknln 50
                     ++d ++n+L++++ +
      EFC39556.1 54 EEFDLQTNQLLLRKRR 69
                    5788899999988765 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00037
  Pih1_fungal_CS  23 ieselesskdlevsYdakeneLiiknlntqeyke 56 
                     + +   +++ ++v+ d++++e++i+ +n+++yk+
      EFC39556.1 119 VRNCFYEPNVYKVNIDHEKQEIVISTTNKKYYKR 152
                     4555667889**********************75 PP

  == domain 3  score: 2.8 bits;  conditional E-value: 0.028
  Pih1_fungal_CS  29 sskdlevsYdakeneLiiknlntqe 53 
                     + +d ++s++ ++n+Lii++ + + 
      EFC39556.1 165 KLNDESLSFKLENNTLIISYVKPDL 189
                     56677899**********9887655 PP

>> Lipocalin_4  Lipocalin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   2.6      0.47   2.8e+03      72      72 ..      49      49 ..       6     114 .. 0.57
   2 ?   10.5   1.3   0.00016      0.93      26      70 ..     138     192 ..      76     208 .. 0.65

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.47
                 S CS
  Lipocalin_4 72 g 72
                 g
   EFC39556.1 49 G 49
                 2 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00016
                  ..EEE-S.S..S-EEE----..SS----..-EEEEEEEETTTTEEEE.......T CS
  Lipocalin_4  26 syitfna.ntttfesyttydggscnesk..desgtytisgnkltitv.......t 70 
                   +i ++  n++ +++++  d +++  +k  des  +++++n+l i++        
   EFC39556.1 138 QEIVISTtNKKYYKRFSIPDMKESPKTKlnDESLSFKLENNTLIISYvkpdlilK 192
                  222222212344445555555444333366***************9966666552 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (220 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.45u 0.26s 00:00:00.71 Elapsed: 00:00:00.42
# Mc/sec: 1563.94
//
Query:       EFC39557.1  [L=433]
Description: hypothetical protein NAEGRDRAFT_81229 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.1e-79  265.6   1.7    4.8e-79  265.0   1.7    1.2  1  IFT46_B_C  Intraflagellar transport complex B protein 46 C te


Domain annotation for each model (and alignments):
>> IFT46_B_C  Intraflagellar transport complex B protein 46 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  265.0   1.7   2.7e-83   4.8e-79       7     212 .]     201     425 ..     193     425 .. 0.94

  Alignments for each domain:
  == domain 1  score: 265.0 bits;  conditional E-value: 2.7e-83
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...... CS
   IFT46_B_C   7 yenlevsaeikelfeyitrYtpqeieldtkLkpFipdyiPavGdiDaflKvprpdeked...kLGLtvlDePsaeqSdptvldlklrevskks...... 96 
                 ++++++s+e+kelf+yi+rY+p+eieldtkLkpFipdy++avG++D f+K++rpd ked   +LGL+v+DeP+ +qSdptv++l+l+ ++k        
  EFC39557.1 201 LSKMNISNELKELFTYINRYKPHEIELDTKLKPFIPDYMAAVGELDPFIKLKRPDLKEDeldDLGLKVIDEPNPSQSDPTVVTLDLTYQMKGDrtssta 299
                 5789**************************************************8877755589**********************6666665666666 PP

                 ...........XXX.XXXXXXXXXXXXXXHHHHHHHHHHHHHHHHHH-TT----SS----TTGGGS---HHHHHHHTT----TT-TT--HHHHHHHHHH CS
   IFT46_B_C  97 ...........aakekskvvksienaeknpkkidkWiedieelhkkkppptveyskkmpdieelmqewpeefeealkkvklpsaeldlsLeeyvkiica 184
                            aak++++++ks+e  + n+k i kWi+di+elhkkkppptv+ysk + d+++l+q wp++fee+l+k++lp a+ld++Leeyvkiic+
  EFC39557.1 300 aessnlssgivAAKKPETIIKSVE--SGNDKLILKWINDIRELHKKKPPPTVTYSKVNVDFTQLIQAWPDAFEEELAKTDLPGADLDVDLEEYVKIICS 396
                 7888999999988889******99..899********************************************************************** PP

                 HHT----.THHHHHHHHHHHHHHHHHHHH CS
   IFT46_B_C 185 ildiPve.ksliesLhlLFtlYlefknsq 212
                 +ldiPv+ ++liesLh+LFtlYl+fk++q
  EFC39557.1 397 LLDIPVYdGHLIESLHVLFTLYLDFKTNQ 425
                 *******99*****************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (433 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       839  (0.0467957); expected 358.6 (0.02)
Passed bias filter:                      356  (0.0198561); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 2641.86
//
Query:       EFC39558.1  [L=1008]
Description: rabGTPase-activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.4e-46  158.1   6.9    6.6e-46  156.7   6.9    1.8  1  RabGAP-TBC  Rab-GTPase-TBC domain
    1.1e-07   32.3   6.0    8.3e-05   23.1   0.9    2.9  2  Ank_2       Ankyrin repeats (3 copies)
    2.1e-06   27.9   0.4       0.84   10.2   0.0    3.7  3  Ank         Ankyrin repeat
    2.5e-06   27.7   0.4    0.00037   20.7   0.1    3.0  2  Ank_5       Ankyrin repeats (many copies)
      3e-05   24.5   0.2        1.9    9.2   0.1    3.5  3  Ank_4       Ankyrin repeats (many copies)
    0.00029   21.0   0.8          3    8.7   0.0    3.9  3  Ank_3       Ankyrin repeat


Domain annotation for each model (and alignments):
>> RabGAP-TBC  Rab-GTPase-TBC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  156.7   6.9   2.2e-49   6.6e-46       2     214 ..     751     958 ..     750     959 .. 0.90

  Alignments for each domain:
  == domain 1  score: 156.7 bits;  conditional E-value: 2.2e-49
  RabGAP-TBC   2 elRgevWklllgyepevkrlkksekkqeksekeksklekseeskelsqIkkDvprtfp.es.esfknkqgqnqLeriLkaysiynpevgYcqGmndiva 98 
                 e+Rge+W +l +++           k+++s+ +++ ++     k+ +qI+ D++r f+ ++ + +++++ q  L++iL+ay++yn ++gY+qGm+ i+a
  EFC39558.1 751 EVRGEAWFYLTRAH---------ILKKQNSKLYSDLKQRPLTMKDSKQIDVDIKREFReHRlFAHRYGKYQVILFNILRAYCNYNVKLGYTQGMSSIAA 840
                 78*********993.........44555555555555555555669************5559************************************* PP

  RabGAP-TBC  99 plllvsldeeeaFwcfvsLl..ekyklrdlytsslpglkrklkvleellkkkdpklykhl.keegldlelfaikwfltlflrefpletvlrlwDlll.e 193
                 +ll ++l+ee+aFw+f+s++  ++y+++++y+ +lpg+ ++  vl ++l+kk++k++k + +e g+ ++ f+++w++  +l+++++++++ +wDl+l e
  EFC39558.1 841 MLL-MYLNEEDAFWVFCSIMegQNYNMQEMYFAGLPGVYKATFVLTNILSKKMKKFMKAFeNEDGIGFNSFCTRWYMLNMLTQIHFDIAVLIWDLYLsE 938
                 ***.999*****************************************************6668******************************55549 PP

  RabGAP-TBC 194 gekfvllrvalailklleeel 214
                 g+k+ + +v++a+++ +++ l
  EFC39558.1 939 GNKV-IHSVSMAFIRIFKKNL 958
                 9988.***********99876 PP

>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.3   0.7   0.00027      0.81      37      76 ..     508     553 ..     420     564 .. 0.76
   2 !   23.1   0.9   2.8e-08   8.3e-05      24      79 ..     576     639 ..     555     642 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00027
       Ank_2  37 gnleivklLleh....ad....ndgrtpLhyAarsghleivklLlekg 76 
                 g   ++kl++++    ++    ++g+t+Lh+A+  +h+ +  lL++++
  EFC39558.1 508 G--VFAKLIVKEeiltLNsiepESGNTALHAAINGDHIGTSSLLCKCK 553
                 4..445666664555533444666778888887435666666666443 PP

  == domain 2  score: 23.1 bits;  conditional E-value: 2.8e-08
       Ank_2  24 k.ngktaLhyAakngnleivklLleh.......adndgrtpLhyAarsghleivklLlekgadi 79 
                 +  ++t+Lh+++ ++  +++ lLl++       +d +g+t+L++Aa + ++ i    +e+g d+
  EFC39558.1 576 NkRKETPLHISVLKNFANVAHLLLQNgskafelTDANGNTALQLAAIYEREAISHSICEHGGDV 639
                 13779**********99*******9667787877799***********9977777888887676 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.1   0.00067         2       2      14 ..     530     542 ..     529     559 .. 0.68
   2 !   10.2   0.0   0.00028      0.84       4      24 ..     581     602 ..     579     610 .. 0.81
   3 ?    4.4   0.0      0.02        58       1      11 [.     612     625 ..     612     651 .. 0.72

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00067
                 SBBHHHHHHHHTT CS
         Ank   2 GnTPLHlAatngk 14 
                 GnT+LH A+++++
  EFC39558.1 530 GNTALHAAINGDH 542
                 9********6665 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00028
                 BHHHHHHHHTT.HHHHHHHH.TT CS
         Ank   4 TPLHlAatngk.kriiklLL.hG 24 
                 TPLH+ +  ++ +++++lLL +G
  EFC39558.1 581 TPLHISVL-KNfANVAHLLLqNG 602
                 *****885.55599******667 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.02
                 TSBBHHHHHH...H CS
         Ank   1 dGnTPLHlAa...t 11 
                 +GnT+L lAa   +
  EFC39558.1 612 NGNTALQLAAiyeR 625
                 8********95542 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   0.0     0.026        77      13      28 ..     527     542 ..     522     544 .. 0.84
   2 !   20.7   0.1   1.2e-07   0.00037       8      56 .]     571     620 ..     568     620 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.026
       Ank_5  13 dgggntpLhvAakyga 28 
                  + gnt+Lh A+++ +
  EFC39558.1 527 PESGNTALHAAINGDH 542
                 5789********9887 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 1.2e-07
       Ank_5   8 dvnrldgggntpLhvAakygaadvvrlLlargadlnltdsrG.ltaldlA 56 
                 +++ ++++++tpLh+++ ++ a+v+ lLl +g+ ++  ++ + +tal+lA
  EFC39558.1 571 NIDQYNKRKETPLHISVLKNFANVAHLLLQNGSKAFELTDANgNTALQLA 620
                 5677888889*******************88887765555555*****99 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.5   0.0    0.0043        13      28      46 ..     523     541 ..     511     549 .. 0.79
   2 !    8.6   0.0   0.00095       2.9      28      55 .]     573     599 ..     553     599 .. 0.87
   3 !    9.2   0.1   0.00064       1.9      16      46 ..     594     624 ..     593     630 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.0043
       Ank_4  28 naqdnrsGetalhiAakrg 46 
                 n   ++sG+talh A+ + 
  EFC39558.1 523 NSIEPESGNTALHAAINGD 541
                 555699*********9554 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.00095
       Ank_4  28 naqdnrsGetalhiAakrgnveilklLl 55 
                 +   n++ et+lhi +++++ ++++lLl
  EFC39558.1 573 DQY-NKRKETPLHISVLKNFANVAHLLL 599
                 444.888******************997 PP

  == domain 3  score: 9.2 bits;  conditional E-value: 0.00064
       Ank_4  16 lvrlLlekgadinaqdnrsGetalhiAakrg 46 
                 +++lLl++g    + ++++G+tal+ Aa  +
  EFC39558.1 594 VAHLLLQNGSKAFELTDANGNTALQLAAIYE 624
                 6899****98888888***********9655 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0      0.12   3.6e+02       2      14 ..     530     542 ..     529     561 .. 0.71
   2 !    8.7   0.0     0.001         3       3      26 ..     580     602 ..     578     605 .. 0.90
   3 !    6.0   0.0    0.0077        23       1      29 [.     612     639 ..     612     641 .. 0.84

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.12
       Ank_3   2 GetpLhlAarsgn 14 
                 G+t+Lh A+  ++
  EFC39558.1 530 GNTALHAAINGDH 542
                 9*****6665444 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.001
       Ank_3   3 etpLhlAarsgnleivkfLlenkg 26 
                 etpLh+ ++ +  +++++Ll+ +g
  EFC39558.1 580 ETPLHISVLKNFANVAHLLLQ-NG 602
                 8*******************9.56 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.0077
       Ank_3   1 nGetpLhlAarsgnleivkfLlenkgadv 29 
                 nG+t+L lAa + + +i + ++e +g dv
  EFC39558.1 612 NGNTALQLAAIYEREAISHSICE-HGGDV 639
                 7************9997777777.67776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1008 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1532  (0.0854482); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.85u 0.33s 00:00:01.18 Elapsed: 00:00:00.52
# Mc/sec: 5841.38
//
Query:       EFC39559.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.7e-49  160.0  31.6    0.00026   20.8   0.1   15.0 16  LRR_6         Leucine Rich repeat
    5.4e-28   96.5  30.8      3e-07   30.1   0.6    6.5  8  LRR_8         Leucine rich repeat
    1.1e-27   95.6  42.1    7.6e-05   23.0   0.2    9.0  9  LRR_4         Leucine Rich repeats (2 copies)
    9.8e-08   31.7   8.6      0.044   13.3   0.4    4.2  4  LRR_9         Leucine-rich repeat
    3.3e-07   29.9  23.8         14    6.8   0.0   11.4 11  LRR_1         Leucine Rich Repeat
    6.2e-07   29.4   2.5       0.39   10.5   0.1    6.0  7  DUF4347       Domain of unknown function (DUF4347)
    0.00035   21.1   0.3        7.1    7.3   0.0    4.6  5  Apo-VLDL-II   Apovitellenin I (Apo-VLDL-II)
  ------ inclusion threshold ------
       0.94    8.9  12.0         11    5.5   0.1    4.8  5  RNA_pol_I_TF  RNA polymerase I specific initiation factor
        1.3    9.6  11.4        2.2    8.8   0.2    4.6  3  SF3A3         Pre-mRNA-splicing factor SF3A3, of SF3a complex
        2.4    7.9  11.9          4    7.2   0.9    4.1  6  DUF4869       Domain of unknown function (DUF4869)


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.2       3.2   5.7e+03      10      16 ..       8      15 ..       8      17 .. 0.74
   2 !   15.7   0.0     6e-06     0.011       5      24 .]      28      47 ..      25      47 .. 0.92
   3 !   20.8   0.1   1.5e-07   0.00026       5      23 ..      52      70 ..      49      71 .. 0.92
   4 !   12.7   0.0   5.9e-05      0.11      12      24 .]      83      95 ..      73      95 .. 0.84
   5 ?    5.5   0.0     0.011        20       5      22 ..     100     117 ..      97     118 .. 0.81
   6 !   12.2   0.0   8.5e-05      0.15       5      24 .]     124     143 ..     120     143 .. 0.89
   7 !    8.0   0.1    0.0018       3.2       5      23 ..     148     166 ..     145     166 .. 0.92
   8 !   11.8   0.1   0.00011       0.2       4      23 ..     171     190 ..     168     191 .. 0.90
   9 ?    2.4   0.0      0.11     2e+02       4      23 ..     195     214 ..     192     215 .. 0.88
  10 !   14.8   0.0   1.2e-05     0.022       5      23 ..     220     238 ..     217     239 .. 0.91
  11 ?    5.2   0.0     0.014        25      11      24 .]     250     263 ..     241     263 .. 0.75
  12 !   17.4   0.1   1.8e-06    0.0032       4      24 .]     267     287 ..     264     287 .. 0.90
  13 !   17.5   0.0   1.6e-06    0.0029       5      24 .]     292     311 ..     289     311 .. 0.93
  14 !   10.8   0.1   0.00024      0.43       5      24 .]     316     335 ..     313     335 .. 0.86
  15 !   14.0   0.1   2.1e-05     0.038       5      23 ..     340     358 ..     337     358 .. 0.92
  16 ?   -2.6   0.1       4.5   8.1e+03       4      10 ..     363     369 ..     361     369 .. 0.81

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 3.2
       LRR_6 10 LsgNd.Ig 16
                +s+N+ Ig
  EFC39559.1  8 ISCNNnIG 15
                68888798 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 6e-06
       LRR_6  5 LteLdLsgNdIgDeGaeaLa 24
                Lt+L +s+N+Ig eGa+ ++
  EFC39559.1 28 LTHLYISSNKIGVEGAKYIS 47
                9***************9885 PP

  == domain 3  score: 20.8 bits;  conditional E-value: 1.5e-07
       LRR_6  5 LteLdLsgNdIgDeGaeaL 23
                Lt Ld+s+N+Ig eG+e +
  EFC39559.1 52 LTNLDISYNNIGAEGVEHI 70
                9****************98 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 5.9e-05
       LRR_6 12 gNdIgDeGaeaLa 24
                +N+IgDeGa+ L+
  EFC39559.1 83 HNNIGDEGAKHLS 95
                9*********996 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.011
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+L  ++N+Ig eG++ 
  EFC39559.1 100 LTYLYTAFNNIGVEGVKY 117
                 66666689********96 PP

  == domain 6  score: 12.2 bits;  conditional E-value: 8.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +L++ +N++gDeGa+ L+
  EFC39559.1 124 LSYLNICSNKVGDEGAKYLS 143
                 789*************9885 PP

  == domain 7  score: 8.0 bits;  conditional E-value: 0.0018
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++s  +I  +G+e +
  EFC39559.1 148 LTNLNISNSNICAKGVEHI 166
                 9***************986 PP

  == domain 8  score: 11.8 bits;  conditional E-value: 0.00011
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L++s N+Ig eGa+ +
  EFC39559.1 171 QLTILNISTNNIGIEGAKYI 190
                 69***************977 PP

  == domain 9  score: 2.4 bits;  conditional E-value: 0.11
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L++ + +I+ eGa+ +
  EFC39559.1 195 QLTCLNIYYSNIDIEGAKYI 214
                 59***************987 PP

  == domain 10  score: 14.8 bits;  conditional E-value: 1.2e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++s+N+Ig eGa+ +
  EFC39559.1 220 LTDLNISYNNIGIEGAKYI 238
                 9***************977 PP

  == domain 11  score: 5.2 bits;  conditional E-value: 0.014
       LRR_6  11 sgNd.IgDeGaeaLa 24 
                   N+ I DeGa+ ++
  EFC39559.1 250 Y-NNyICDEGAKYIS 263
                 4.555******9885 PP

  == domain 12  score: 17.4 bits;  conditional E-value: 1.8e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt L++ +N+IgDeGa+ ++
  EFC39559.1 267 QLTNLNIYSNNIGDEGAKYIS 287
                 69***************9885 PP

  == domain 13  score: 17.5 bits;  conditional E-value: 1.6e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+s N+Ig +G++ +a
  EFC39559.1 292 LTNLDISVNQIGAKGVKYIA 311
                 9****************987 PP

  == domain 14  score: 10.8 bits;  conditional E-value: 0.00024
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L+ s N+I DeGa+ ++
  EFC39559.1 316 LTILSASLNNIRDEGAKYIS 335
                 8888889*********9885 PP

  == domain 15  score: 14.0 bits;  conditional E-value: 2.1e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt Ld+s+N+I+ eG++++
  EFC39559.1 340 LTNLDISSNNISIEGVKCF 358
                 9***************985 PP

  == domain 16  score: -2.6 bits;  conditional E-value: 4.5
       LRR_6   4 hLteLdL 10 
                 hLt L++
  EFC39559.1 363 HLTVLEI 369
                 9**9986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.6   1.7e-10     3e-07       2      61 .]       3      62 ..       2      62 .. 0.97
   2 !   23.3   1.1   2.3e-08   4.1e-05       2      61 .]      51     110 ..      50     110 .. 0.97
   3 !   22.1   2.3   5.3e-08   9.4e-05       2      61 .]     123     182 ..     122     182 .. 0.98
   4 !   13.2   0.1   3.2e-05     0.058      22      61 .]     191     230 ..     183     230 .. 0.92
   5 !   13.6   0.1   2.4e-05     0.044       3      61 .]     196     254 ..     194     254 .. 0.81
   6 !   17.3   0.9   1.6e-06    0.0029       2      61 .]     243     302 ..     242     302 .. 0.94
   7 !   16.8   3.2   2.4e-06    0.0043       2      61 .]     267     326 ..     266     326 .. 0.97
   8 !   19.7   0.7     3e-07   0.00054       2      55 ..     315     368 ..     314     370 .. 0.93

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 1.7e-10
                T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +Lt+L+ +nN++ + + +  + l++L++L++s+N++ +  ++ +s L++L+ Ld+s+N++
  EFC39559.1  3 SLTKLISCNNNIGVEEAKYISELKQLTHLYISSNKIGVEGAKYISELKQLTNLDISYNNI 62
                79999999999***********************************************97 PP

  == domain 2  score: 23.3 bits;  conditional E-value: 2.3e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+Ld+s N++ + + e   +l++L+ L + +N++    ++ +s L++L++L+   N++
  EFC39559.1  51 QLTNLDISYNNIGAEGVEHIGNLKQLTFLCIYHNNIGDEGAKHLSALKQLTYLYTAFNNI 110
                 7*****************************************************999986 PP

  == domain 3  score: 22.1 bits;  conditional E-value: 5.3e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +L++L++++N+  + + +  + l++L+ L++sn ++     + +  +++L+ L++s N++
  EFC39559.1 123 QLSYLNICSNKVGDEGAKYLSELKQLTNLNISNSNICAKGVEHITEMNQLTILNISTNNI 182
                 799*******************************************************97 PP

  == domain 4  score: 13.2 bits;  conditional E-value: 3.2e-05
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  +l++L+ L++ + +++   ++ +s +++L+ L++s+N++
  EFC39559.1 191 GKLKQLTCLNIYYSNIDIEGAKYISEMKQLTDLNISYNNI 230
                 57999*********************************97 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 2.4e-05
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 Lt L++  +++   + +  + +++L+ L++s+N++    ++ +  L++L+ L++ +N +
  EFC39559.1 196 LTCLNIYYSNIDIEGAKYISEMKQLTDLNISYNNIGIEGAKYIGKLKQLTCLTIYNNYI 254
                 66666667777777777888899999999999999999999999999999999988865 PP

  == domain 6  score: 17.3 bits;  conditional E-value: 1.6e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L + nN++ + + +  + l++L+ L++ +N++    ++ +s L++L+ Ld+s N++
  EFC39559.1 243 QLTCLTIYNNYICDEGAKYISELNQLTNLNIYSNNIGDEGAKYISELKQLTNLDISVNQI 302
                 6888999999999999999*************************************9997 PP

  == domain 7  score: 16.8 bits;  conditional E-value: 2.4e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L++ +N++ + + +  + l++L+ Ld+s N++     + ++ L++L+ L  s N++
  EFC39559.1 267 QLTNLNIYSNNIGDEGAKYISELKQLTNLDISVNQIGAKGVKYIAELNQLTILSASLNNI 326
                 79****************************************************999987 PP

  == domain 8  score: 19.7 bits;  conditional E-value: 3e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 +Lt+L+ s N++ + + +  + l++L+ Ld+s+N+++    ++f+ +++L+ L 
  EFC39559.1 315 QLTILSASLNNIRDEGAKYISELKQLTNLDISSNNISIEGVKCFEEMKHLTVLE 368
                 68899999999***************************99**********9996 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.3      0.24   4.3e+02      22      36 ..       1      14 [.       1      26 [. 0.80
   2 !   23.0   0.2   4.2e-08   7.6e-05       1      34 [.      26      61 ..      26      66 .. 0.84
   3 !   15.5   0.0   9.7e-06     0.017       1      34 [.      74     109 ..      74     117 .. 0.87
   4 !   12.7   1.9   7.5e-05      0.13       2      35 ..     123     157 ..     122     165 .. 0.86
   5 !   13.5   0.2   4.2e-05     0.076       2      39 ..     171     208 ..     170     213 .. 0.75
   6 !   17.4   0.1   2.4e-06    0.0043       1      37 [.     218     255 ..     218     265 .. 0.85
   7 !   17.2   0.7   2.8e-06    0.0051       2      36 ..     267     302 ..     266     306 .. 0.85
   8 !   18.2   1.5   1.3e-06    0.0024       2      38 ..     315     351 ..     314     357 .. 0.82
   9 !   15.4   0.4     1e-05     0.018       1      30 [.     338     369 ..     338     371 .] 0.87

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.24
                -TT--EEE-.-S--- CS
       LRR_4 22 lpnLkeLdLsgNnli 36
                +++L++L +s Nn+i
  EFC39559.1  1 MKSLTKL-ISCNNNI 14
                7899999.8778877 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 4.2e-08
                SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4  1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34
                ++L++L++s+N++   +   ++ l++L+ Ld+s Nn
  EFC39559.1 26 KQLTHLYISSNKIGVEGAkyISELKQLTNLDISYNN 61
                58************766676445*********9994 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 9.7e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 ++L++L++ +N++ d +   l+ l++L++L+  +Nn
  EFC39559.1  74 KQLTFLCIYHNNIGDEGAkhLSALKQLTYLYTAFNN 109
                 58*************99998778********87773 PP

  == domain 4  score: 12.7 bits;  conditional E-value: 7.5e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 +L +L++ +N++ d +   l+ l++L+ L++s+  +
  EFC39559.1 123 QLSYLNICSNKVGDEGAkyLSELKQLTNLNISNS-N 157
                 7889**********99998778*********654.3 PP

  == domain 5  score: 13.5 bits;  conditional E-value: 4.2e-05
                 S--EEE--.SS.---E-S-HHH-TT--EEE-..-S-----G CS
       LRR_4   2 nLevLdLs.nN.qltdiplleklpnLkeLdL.sgNnlitdl 39 
                 +L++L++s nN  +     ++kl++L+ L++  +N  i d+
  EFC39559.1 171 QLTILNIStNNiGIEGAKYIGKLKQLTCLNIyYSN--I-DI 208
                 69******77555666666889*********4334..5.66 PP

  == domain 6  score: 17.4 bits;  conditional E-value: 2.4e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 ++L+ L++s N++  i++   ++kl++L+ L++  Nn+i 
  EFC39559.1 218 KQLTDLNISYNNIG-IEGakyIGKLKQLTCLTI-YNNYIC 255
                 589******99999.777565668*********.888994 PP

  == domain 7  score: 17.2 bits;  conditional E-value: 2.8e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L++ +N++ d +   ++ l++L+ Ld+s N +i
  EFC39559.1 267 QLTNLNIYSNNIGDEGAkyISELKQLTNLDISVN-QI 302
                 69************99986445*********555.87 PP

  == domain 8  score: 18.2 bits;  conditional E-value: 1.3e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 +L++L+ s N+++d +   ++ l++L+ Ld+s+N +i +
  EFC39559.1 315 QLTILSASLNNIRDEGAkyISELKQLTNLDISSN-NI-S 351
                 69******88****99986445*********888.44.4 PP

  == domain 9  score: 15.4 bits;  conditional E-value: 1e-05
                 SS--EEE--SS---E-S-...HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdL 30 
                 ++L++Ld+s+N+++ i++   +e +++L++L +
  EFC39559.1 338 KQLTNLDISSNNIS-IEGvkcFEEMKHLTVLEI 369
                 58***********9.777788889*******87 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.0    0.0001      0.18      60     127 ..      22      88 ..       6     105 .. 0.84
   2 !    7.3   0.4    0.0017       3.1      57     145 ..     112     199 ..     106     206 .. 0.60
   3 !   13.3   0.4   2.4e-05     0.044      43     129 ..     219     306 ..     214     321 .. 0.77
   4 !    5.3   0.1    0.0072        13      42      99 ..     290     349 ..     278     369 .. 0.40

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.0001
       LRR_9  60 fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 +  lk+l  l++++n+i   + +    l +l++l ++ n++   + ++ + +lk+l++l++ +n + +
  EFC39559.1  22 ISELKQLTHLYISSNKIGVEGAKYISELKQLTNLDISYNNIGAEG-VEHIGNLKQLTFLCIYHNNIGD 88 
                 456899999********9999999999*************99755.69***************99865 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0017
       LRR_9  57 ldgfPllkrlktlllnnnrivriaegleevlPnle...elvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrll 145
                 ++g+ ++ +lk l+  n    +++++ +++l +l+   +l ++n+++     ++ ++++++l++l + +n +  +       i klkql+ l
  EFC39559.1 112 VEGVKYIIKLKQLSYLNICSNKVGDEGAKYLSELKqltNLNISNSNICAK-GVEHITEMNQLTILNISTNNIGIEG---AKYIGKLKQLTCL 199
                 56667777777766666666666666666665555000555566666543.4688888888888888877765432...2335666666655 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 2.4e-05
       LRR_9  43 qfdtidlsdndirkldg...fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                 q+  +++s n+i  ++g   +  lk+l +l + nn i+  + +    l +l++l + +n++ + +  + + +lk+l++l +  n + +k 
  EFC39559.1 219 QLTDLNISYNNIG-IEGakyIGKLKQLTCLTIYNNYICDEGAKYISELNQLTNLNIYSNNIGDEGA-KYISELKQLTNLDISVNQIGAKG 306
                 5556677777763.44400045577888999*******************************9988.89999****99999999887764 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.0072
       LRR_9  42 dqfdtidlsdndi..rkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnne 99 
                  q+  +d+s n+i  + +  +  l++l +l+ + n i+  + +    l +l++l +++n+
  EFC39559.1 290 KQLTNLDISVNQIgaKGVKYIAELNQLTILSASLNNIRDEGAKYISELKQLTNLDISSNN 349
                 444444555555411122222222233333333333333333333333333333333333 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       9.6   1.7e+04       7      13 ..       8      14 ..       3      23 .. 0.57
   2 !    6.8   0.0    0.0075        14       1      21 [.      27      47 ..      27      49 .. 0.79
   3 ?    5.2   0.0     0.024        43       2      22 ..      52      72 ..      51      73 .. 0.79
   4 ?    2.9   0.0      0.14   2.5e+02       2      23 .]      76      97 ..      75      97 .. 0.87
   5 ?    1.9   0.0       0.3   5.4e+02       2      21 ..     124     143 ..     123     145 .. 0.77
   6 ?    1.5   0.1      0.41   7.4e+02       2      13 ..     148     159 ..     147     168 .. 0.76
   7 ?    2.4   0.2       0.2   3.5e+02       2      13 ..     172     183 ..     171     210 .. 0.78
   8 ?    4.0   0.1      0.06   1.1e+02       2      14 ..     220     232 ..     219     265 .. 0.76
   9 ?    3.3   0.0      0.11   1.9e+02       2      22 ..     268     288 ..     267     289 .. 0.80
  10 ?    1.6   0.0      0.37   6.6e+02       2      13 ..     292     303 ..     291     329 .. 0.72
  11 ?    5.9   0.0     0.015        26       2      21 ..     340     359 ..     339     361 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 9.6
       LRR_1  7 Lsnnpll 13
                +s n+++
  EFC39559.1  8 ISCNNNI 14
                4444443 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.0075
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                +L+hL++s+n ++  ++ +++
  EFC39559.1 27 QLTHLYISSNKIGVEGAKYIS 47
                59********99777766665 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.024
       LRR_1  2 LrhLdLsnnpllglppnsfqn 22
                L+ Ld+s+n+++  + +++ n
  EFC39559.1 52 LTNLDISYNNIGAEGVEHIGN 72
                899*******97777777766 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.14
       LRR_1  2 LrhLdLsnnpllglppnsfqnL 23
                L+ L + +n++++ ++ +++ L
  EFC39559.1 76 LTFLCIYHNNIGDEGAKHLSAL 97
                899********99999998865 PP

  == domain 5  score: 1.9 bits;  conditional E-value: 0.3
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L +L++++n  ++ ++ +++
  EFC39559.1 124 LSYLNICSNKVGDEGAKYLS 143
                 889******98777777665 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.41
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L++sn ++ 
  EFC39559.1 148 LTNLNISNSNIC 159
                 899***999884 PP

  == domain 7  score: 2.4 bits;  conditional E-value: 0.2
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L++s n+++
  EFC39559.1 172 LTILNISTNNIG 183
                 999***888873 PP

  == domain 8  score: 4.0 bits;  conditional E-value: 0.06
       LRR_1   2 LrhLdLsnnpllg 14 
                 L+ L++s+n+++ 
  EFC39559.1 220 LTDLNISYNNIGI 232
                 8889999999833 PP

  == domain 9  score: 3.3 bits;  conditional E-value: 0.11
       LRR_1   2 LrhLdLsnnpllglppnsfqn 22 
                 L+ L++ +n++++ ++ +++ 
  EFC39559.1 268 LTNLNIYSNNIGDEGAKYISE 288
                 899***999998888877765 PP

  == domain 10  score: 1.6 bits;  conditional E-value: 0.37
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ Ld+s n+++
  EFC39559.1 292 LTNLDISVNQIG 303
                 899****99983 PP

  == domain 11  score: 5.9 bits;  conditional E-value: 0.015
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ Ld+s+n+++  +  +f+
  EFC39559.1 340 LTNLDISSNNISIEGVKCFE 359
                 899*******9888888887 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.68   1.2e+03      97     123 ..       9      35 ..       5      40 .. 0.80
   2 ?    3.1   0.0     0.042        76      95     122 ..      31      58 ..      17      72 .. 0.76
   3 ?   -1.4   0.0      0.99   1.8e+03      86     117 ..      72     101 ..      51     109 .. 0.67
   4 !    5.3   0.0     0.009        16      98     125 ..     130     157 ..      87     160 .. 0.86
   5 ?    0.5   0.0      0.27   4.9e+02     105     120 ..     209     224 ..     161     251 .. 0.65
   6 !   10.5   0.1   0.00022      0.39      78     123 ..     256     299 ..     211     307 .. 0.75
   7 ?    3.3   0.0     0.038        68     103     124 ..     327     348 ..     308     352 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.68
     DUF4347  97 gCnvAageaGeafvekLaqltgadvaA 123
                 +Cn   g +  +++++L+qlt+  +++
  EFC39559.1   9 SCNNNIGVEEAKYISELKQLTHLYISS 35 
                 7888888889999********998865 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.042
     DUF4347  95 lYgCnvAageaGeafvekLaqltgadva 122
                 lY  +   g +G +++++L+qlt+ d++
  EFC39559.1  31 LYISSNKIGVEGAKYISELKQLTNLDIS 58 
                 45555555678*************9995 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 0.99
     DUF4347  86 alsedadillYgCnvAageaGeafvekLaqlt 117
                 +l++   + +Y  n++ +  G + +++L+qlt
  EFC39559.1  72 NLKQLTFLCIYHNNIGDE--GAKHLSALKQLT 101
                 455555667777777654..888888888887 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.009
     DUF4347  98 CnvAageaGeafvekLaqltgadvaAst 125
                 C+   g++G +++++L+qlt+ +++ s+
  EFC39559.1 130 CSNKVGDEGAKYLSELKQLTNLNISNSN 157
                 66667899***************99875 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.27
     DUF4347 105 aGeafvekLaqltgad 120
                 +G +++++++qlt  +
  EFC39559.1 209 EGAKYISEMKQLTDLN 224
                 3555555555555555 PP

  == domain 6  score: 10.5 bits;  conditional E-value: 0.00022
     DUF4347  78 eelaqwgealsedadillYgCnvAageaGeafvekLaqltgadvaA 123
                 +e a++ ++l++  ++ +Y+ n++ +  G +++++L+qlt+ d++ 
  EFC39559.1 256 DEGAKYISELNQLTNLNIYSNNIGDE--GAKYISELKQLTNLDISV 299
                 44556668899999*********876..***************964 PP

  == domain 7  score: 3.3 bits;  conditional E-value: 0.038
     DUF4347 103 geaGeafvekLaqltgadvaAs 124
                  ++G +++++L+qlt+ d++++
  EFC39559.1 327 RDEGAKYISELKQLTNLDISSN 348
                 478***************9865 PP

>> Apo-VLDL-II  Apovitellenin I (Apo-VLDL-II)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.47   8.5e+02      21      49 ..      30      58 ..      16      71 .. 0.82
   2 ?    5.4   0.0     0.015        27      20      62 ..     101     143 ..      98     155 .. 0.84
   3 ?    2.9   0.0     0.095   1.7e+02      21      61 ..     126     167 ..     118     182 .. 0.76
   4 ?   -0.0   0.0      0.75   1.3e+03      26      67 ..     227     268 ..     223     274 .. 0.82
   5 !    7.3   0.0     0.004       7.1      25      65 ..     298     338 ..     293     344 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.47
  Apo-VLDL-II 21 yvyeavnkvsPkvaqflvdivqipvvlet 49
                 ++y + nk+    a+++ +  q + +  +
   EFC39559.1 30 HLYISSNKIGVEGAKYISELKQLTNLDIS 58
                 57889999999999999999998876655 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.015
  Apo-VLDL-II  20 ayvyeavnkvsPkvaqflvdivqipvvletrniliketakvsi 62 
                  +y+y a+n +     +++++  q + +  + n +  e ak   
   EFC39559.1 101 TYLYTAFNNIGVEGVKYIIKLKQLSYLNICSNKVGDEGAKYLS 143
                  699******************9999999999988888887654 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.095
  Apo-VLDL-II  21 yvyeavnkvsPkvaqflvdivqipvvl.etrniliketakvs 61 
                  y+  + nkv    a++l +  q + +  +  ni +k   +++
   EFC39559.1 126 YLNICSNKVGDEGAKYLSELKQLTNLNiSNSNICAKGVEHIT 167
                  666778****************98775144566667666665 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 0.75
  Apo-VLDL-II  26 vnkvsPkvaqflvdivqipvvletrniliketakvsilfeql 67 
                  +n +    a+++ +  q + ++   n++  e ak    ++ql
   EFC39559.1 227 YNNIGIEGAKYIGKLKQLTCLTIYNNYICDEGAKYISELNQL 268
                  677777889999999999999999999999999976555555 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.004
  Apo-VLDL-II  25 avnkvsPkvaqflvdivqipvvletrniliketakvsilfe 65 
                  +vn++  k  +++++  q ++++++ n +  e ak    + 
   EFC39559.1 298 SVNQIGAKGVKYIAELNQLTILSASLNNIRDEGAKYISELK 338
                  79***************************999999655555 PP

>> RNA_pol_I_TF  RNA polymerase I specific initiation factor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.1       0.8   1.4e+03      35      55 ..      16      36 ..       6      57 .. 0.79
   2 ?    5.5   0.1    0.0059        11      17      56 ..      46      85 ..      34      97 .. 0.83
   3 ?    3.9   0.3     0.018        33      13      58 ..     138     183 ..     126     190 .. 0.83
   4 ?   -0.4   0.1      0.38   6.8e+02      34      57 ..     255     278 ..     221     317 .. 0.71
   5 ?    3.7   0.1     0.021        39      16      59 ..     309     352 ..     293     360 .. 0.84

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.8
  RNA_pol_I_TF 35 syktkhienltqllhlnilrr 55
                   ++ k i++l+ql hl i+++
    EFC39559.1 16 VEEAKYISELKQLTHLYISSN 36
                  557788999999999988765 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0059
  RNA_pol_I_TF 17 likskglevlpdskseirsyktkhienltqllhlnilrrn 56
                   ++ k l  l+ s ++i  +  +hi nl+ql +l+i ++n
    EFC39559.1 46 ISELKQLTNLDISYNNIGAEGVEHIGNLKQLTFLCIYHNN 85
                  5556666677777888888999**************9998 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.018
  RNA_pol_I_TF  13 kanflikskglevlpdskseirsyktkhienltqllhlnilrrnwk 58 
                    a++l++ k l  l+ s+s+i  +  +hi++++ql  lni+ +n  
    EFC39559.1 138 GAKYLSELKQLTNLNISNSNICAKGVEHITEMNQLTILNISTNNIG 183
                   56777888888888888999999999***************99965 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.38
  RNA_pol_I_TF  34 rsyktkhienltqllhlnilrrnw 57 
                    ++  k i++l+ql  lni ++n 
    EFC39559.1 255 CDEGAKYISELNQLTNLNIYSNNI 278
                   555678899999999999998886 PP

  == domain 5  score: 3.7 bits;  conditional E-value: 0.021
  RNA_pol_I_TF  16 flikskglevlpdskseirsyktkhienltqllhlnilrrnwkl 59 
                   + ++ + l +l  s ++ir++  k i++l+ql  l i+++n ++
    EFC39559.1 309 YIAELNQLTILSASLNNIRDEGAKYISELKQLTNLDISSNNISI 352
                   5567788899999**************************99876 PP

>> SF3A3  Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.39     7e+02      33      63 ..      20      51 ..       6      74 .. 0.64
   2 ?    8.8   0.2    0.0012       2.2      13      63 ..      99     147 ..      90     155 .. 0.81
   3 ?   -0.0   3.7      0.71   1.3e+03      24      24 ..     253     253 ..     183     343 .. 0.63

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.39
       SF3A3 33 qYLesfdkfseip.kkqkkskeYkeYlkeLle 63
                +Y++++++++++  +++k   e  +Y++eL++
  EFC39559.1 20 KYISELKQLTHLYiSSNKIGVEGAKYISELKQ 51
                45555555544443444444444555555443 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.0012
       SF3A3  13 DLnelyeeylnlkeikldYlqYLesfdkfseip.kkqkkskeYkeYlkeLle 63 
                  L+ ly++++n+     + ++Y+ +++++s+++  ++k  +e  +Yl+eL++
  EFC39559.1  99 QLTYLYTAFNNIGV---EGVKYIIKLKQLSYLNiCSNKVGDEGAKYLSELKQ 147
                 58899*******95...88888888888888887666778888888888865 PP

  == domain 3  score: -0.0 bits;  conditional E-value: 0.71
       SF3A3  24 l 24 
                 +
  EFC39559.1 253 Y 253
                 2 PP

>> DUF4869  Domain of unknown function (DUF4869)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0         1   1.9e+03      72     100 ..      34      62 ..       8      70 .. 0.70
   2 ?    7.2   0.9    0.0022         4      56     106 ..     114     164 ..     108     190 .. 0.82
   3 ?   -1.3   0.1      0.94   1.7e+03      76     100 ..     206     230 ..     168     250 .. 0.72
   4 ?   -0.0   0.1      0.37   6.7e+02      63     106 ..     217     260 ..     207     276 .. 0.67
   5 ?    5.1   0.2    0.0095        17      67     104 ..     269     306 ..     249     326 .. 0.78
   6 ?   -0.6   0.0      0.54   9.7e+02      73     108 ..     323     358 ..     303     364 .. 0.67

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 1
     DUF4869  72 nvsacGdnCakwlleiakkkdltinlrhi 100
                    ++G   ak++ e+ + ++l i+ ++i
  EFC39559.1  34 SSNKIGVEGAKYISELKQLTNLDISYNNI 62 
                 34456777788888888877777776665 PP

  == domain 2  score: 7.2 bits;  conditional E-value: 0.0022
     DUF4869  56 GvktLlllanedekifnvsacGdnCakwlleiakkkdltinlrhimdfgek 106
                 Gvk ++ l++     ++  ++Gd  ak+l e+ + ++l i+ ++i   g +
  EFC39559.1 114 GVKYIIKLKQLSYLNICSNKVGDEGAKYLSELKQLTNLNISNSNICAKGVE 164
                 9999999999999999999*********************99998877643 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.94
     DUF4869  76 cGdnCakwlleiakkkdltinlrhi 100
                 +    ak++ e+ + +dl i+ ++i
  EFC39559.1 206 IDIEGAKYISEMKQLTDLNISYNNI 230
                 4445567777777777777766655 PP

  == domain 4  score: -0.0 bits;  conditional E-value: 0.37
     DUF4869  63 lanedekifnvsacGdnCakwlleiakkkdltinlrhimdfgek 106
                 +++  +  +   ++G   ak++ ++ + + lti  ++i d g k
  EFC39559.1 217 MKQLTDLNISYNNIGIEGAKYIGKLKQLTCLTIYNNYICDEGAK 260
                 55555555556677777788888888888888877777776644 PP

  == domain 5  score: 5.1 bits;  conditional E-value: 0.0095
     DUF4869  67 dekifnvsacGdnCakwlleiakkkdltinlrhimdfg 104
                  +  +   ++Gd  ak++ e+ + ++l i++++i   g
  EFC39559.1 269 TNLNIYSNNIGDEGAKYISELKQLTNLDISVNQIGAKG 306
                 4555666789*******************999986655 PP

  == domain 6  score: -0.6 bits;  conditional E-value: 0.54
     DUF4869  73 vsacGdnCakwlleiakkkdltinlrhimdfgekkF 108
                 + ++ d  ak++ e+ + ++l i+ ++i   g k F
  EFC39559.1 323 LNNIRDEGAKYISELKQLTNLDISSNNISIEGVKCF 358
                 446678888888888888888888777766555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       500  (0.0278878); expected 358.6 (0.02)
Passed bias filter:                      242  (0.0134977); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.62u 0.35s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2242.50
//
Query:       EFC39560.1  [L=236]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.7e-06   26.4   1.7    8.3e-06   25.6   1.7    1.3  1  zf-CCCH    Zinc finger C-x8-C-x5-C-x3-H type (and similar)
     0.0021   18.1   3.3     0.0033   17.4   3.3    1.3  1  zf_CCCH_4  Zinc finger domain


Domain annotation for each model (and alignments):
>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   1.7   9.3e-10   8.3e-06       5      25 ..      49      69 ..      48      70 .. 0.97

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 9.3e-10
                CBCHHHHHS--TTGGG-SSBS CS
     zf-CCCH  5 lCrffmrtGyCkyGdrCkFaH 25
                +C  + + G+C +G++CkF H
  EFC39560.1 49 PCEAYEKDGFCARGSTCKFKH 69
                7******************** PP

>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   3.3   3.7e-07    0.0033       1      19 []      50      69 ..      50      69 .. 0.97

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 3.7e-07
   zf_CCCH_4  1 Ckfflq.GtCkkGdkCrFaH 19
                C  + + G C +G+ C+F H
  EFC39560.1 50 CEAYEKdGFCARGSTCKFKH 69
                899***************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (236 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       948  (0.0528752); expected 358.6 (0.02)
Passed bias filter:                      390  (0.0217525); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.55u 0.26s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1517.29
//
Query:       EFC39561.1  [L=263]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (263 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       463  (0.0258241); expected 358.6 (0.02)
Passed bias filter:                      362  (0.0201908); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1673.33
//
Query:       EFC39562.1  [L=146]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (146 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       539  (0.030063); expected 358.6 (0.02)
Passed bias filter:                      441  (0.024597); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 903.36
//
Query:       EFC39563.1  [L=279]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
       0.02   14.1   1.0      0.033   13.3   1.0    1.3  1  PDEase_II  cAMP phosphodiesterases class-II


Domain annotation for each model (and alignments):
>> PDEase_II  cAMP phosphodiesterases class-II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   1.0   1.8e-06     0.033     135     224 ..       8     107 ..       6     123 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.8e-06
                 --GGGSTT-......-EEEEE--TT--EE-SSSSEEEEE...........EEEEEEE-TTT--EEE........EEEEEEEET.TT--EEEEE-S---- CS
   PDEase_II 135 Pnlpsfkrvnl..islvklielepkelnkltettldvvanefsfsvkvktfevnhgslikknsevl........Ssaflftde.vskesilvfgDvesd 222
                 P+l s     +  + +++l  + ++ l       +   + +f  s ++  f++ h+s i  ns++l        S++ +f +  +s++ ++v  D +++
  EFC39563.1   8 PSLSSITNTLMiiLMMINLLSMVHSSLCASS-SSWTQKHGDFYMSNSIPDFPLSHSSWISMNSPMLtkmnlkldSTSLIFANApLSGKLLMVLDDDNQQ 105
                 5666665442222445555555566555554.667777889999*********************999************9864899999999988877 PP

                 -T CS
   PDEase_II 223 ls 224
                 l+
  EFC39563.1 106 LV 107
                 65 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (279 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       535  (0.0298399); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.31s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1759.40
//
Query:       EFC39564.1  [L=256]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-62  210.4   2.2    1.7e-62  210.0   2.2    1.1  1  DUF1264   Protein of unknown function (DUF1264)
  ------ inclusion threshold ------
      0.037   14.2   0.6      0.074   13.3   0.2    1.9  1  zf-nanos  Nanos RNA binding domain


Domain annotation for each model (and alignments):
>> DUF1264  Protein of unknown function (DUF1264)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  210.0   2.2   1.9e-66   1.7e-62       2     150 ..      35     180 ..      34     197 .. 0.95

  Alignments for each domain:
  == domain 1  score: 210.0 bits;  conditional E-value: 1.9e-66
     DUF1264   2 kpvkkikahlnafhvyaddpkrqveahhycshlnedlrQcliydsdekdarLigvEYiiseklfetLpeeEkklWHsHeyEvksGllvlpakagvpeaa 100
                 +p+++i++h+++ h ya+d+kr + ahhycsh++ d++Qc+iydsd++da+Lig+EYii+e++++tL+ eE+klWHsH+yEvk Gl+++p   ++p+ +
  EFC39564.1  35 APLHRIHNHICGVHGYAHDMKRSITAHHYCSHIRPDFHQCVIYDSDSPDAKLIGIEYIITEETYNTLDPEEQKLWHSHQYEVKGGLITCP---HIPQLV 130
                 79****************************************************************************************...9***** PP

     DUF1264 101 eeaeleevvklYGKtyhlWqvdrgdklPlGapqLmmsftedgqvklklvk 150
                 e++ +++++k+YGKt+h+Wqvd++ +lPlG pqLmm++t+++++ ++ v+
  EFC39564.1 131 EHQIMKHIIKTYGKTFHTWQVDTQPDLPLGIPQLMMAYTREENMPEAHVR 180
                 *****************************************999866554 PP

>> zf-nanos  Nanos RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.2   8.3e-06     0.074       9      33 ..     104     128 ..      62     133 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 8.3e-06
    zf-nanos   9 eseevyssHslkdedgrvtCPvLrk 33 
                 e+++ + sH+   + g +tCP++ +
  EFC39564.1 104 EEQKLWHSHQYEVKGGLITCPHIPQ 128
                 8899*****************9765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (256 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.24s 00:00:00.73 Elapsed: 00:00:00.43
# Mc/sec: 1789.16
//
Query:       EFC39565.1  [L=650]
Description: hypothetical protein NAEGRDRAFT_44741 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     1e-260  866.1   8.1   1.2e-260  865.9   8.1    1.0  1  HSP70           Hsp70 protein
    1.8e-18   66.5   5.0    3.9e-17   62.1   0.0    3.0  3  MreB_Mbl        MreB/Mbl protein
     0.0048   16.2   0.1      0.031   13.5   0.1    2.1  2  Hydantoinase_A  Hydantoinase/oxoprolinase
  ------ inclusion threshold ------
      0.011   16.1   0.1      0.048   14.0   0.0    2.1  2  CPL             CPL (NUC119) domain
      0.023   14.0   2.0       0.24   10.6   0.5    2.4  2  EAP30           EAP30/Vps36 family
       0.03   14.7   0.6         12    6.4   0.0    3.4  3  FtsA            Cell division protein FtsA
      0.033   13.2   1.5       0.47    9.4   0.1    2.7  3  DDR             Diol dehydratase reactivase ATPase-like domai
      0.069   12.6   0.0          4    6.8   0.0    2.4  2  BcrAD_BadFG     BadF/BadG/BcrA/BcrD ATPase family
       0.53   10.5   5.1         14    5.9   1.6    2.8  2  Cys_rich_FGFR   Cysteine rich repeat
        5.6    7.0  11.5        2.8    7.9   8.3    2.1  3  Erp_C           Erp protein C-terminus


Domain annotation for each model (and alignments):
>> HSP70  Hsp70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  865.9   8.1  6.5e-264  1.2e-260       1     599 []      10     611 ..      10     611 .. 0.98

  Alignments for each domain:
  == domain 1  score: 865.9 bits;  conditional E-value: 6.5e-264
                 EEEEEEXSSEEEEEEEETTEEEEEXXTTSXSSEESEEEEXTTSEEETHHHHHCTTTTGGGEEEXGGGTTTXBTTSHHHHHHHTTXSSEEEEETTSBEEE CS
       HSP70   1 viGiDLGttnsvvavmeggkievianeegnrttPsvvaFtkkerlvGeaAkrqavtnpkntvfsvKrliGrkfsdpevqkeikelpykvvkkengkavv 99 
                 +iGiDLGtt+s+v+v  g+++e+i n++gnrttPs+vaFt++erl+G+aAk+q+++np+ntvf++KrliGrkfsd++vq ++k++p+kv +k+++k+++
  EFC39565.1  10 AIGIDLGTTYSCVGVYMGDNVEIIPNDQGNRTTPSYVAFTDEERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFSDSTVQDDMKHWPFKVITKSDEKPYI 108
                 59************************************************************************************************* PP

                 EEEETTE..EEEHHHHHHHHHHHHHHHHHHHHTSBEEEEEEEEXTTXXHHHHHHHHHHHHHTTXEEEEEEEHHHHHHHHHHTCCSSSCEEEEEEEEXSS CS
       HSP70 100 eveaage..kftpeqisamvLkklketaeaylgkkvtdavitvPaYfndaqRqatkdAgkiAGLnvlRivNepTAaalaYGldkkdkernvlvyDlGgg 196
                 +ve++ge   ftpeqis+mvL+k+k++ e+ylgk+v++avitvPaYfnd+qRqatkdAg+iAGL+vlRi+NepTAaa+aYGl+kk  ernvl++DlGgg
  EFC39565.1 109 QVEYKGEshVFTPEQISSMVLTKMKDISEQYLGKQVKKAVITVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKG-ERNVLIFDLGGG 206
                 *******999***************************************************************************9.************ PP

                 XEEEEEEEEETTEEEEEEEEEETTXSHHHHHHHHHHHHHHHHHHHHSXXGGGSHHHHHHHHHHHHHHHHHTTTSSCSEEEEEEEEEETTTEEEEEEEEH CS
       HSP70 197 tfdvSilelekGvfevkaTagDthlGGedfDealvehlveefkkkegidlskdkkalqrlkeaaekaKkeLSsskqteinleietvdedgkdlseklsR 295
                 tfdvSil++e+GvfevkaTagDthlGGedfD+ +v+++++efk+k++ d++++++al+rl++a+e+aK++LSs  +++++++++++++ g dl+++++R
  EFC39565.1 207 TFDVSILNIEDGVFEVKATAGDTHLGGEDFDNLMVQFCCQEFKRKYKKDIQENPRALRRLRTACERAKRNLSS--AANASINVDSIMD-GIDLDISMTR 302
                 *************************************************************************..899999******9.********** PP

                 HHHHHHHHHHHHHTHHHHHHHHHHCTEEGGGCSEEEEESGGGGSHHHHHHHHHHTT.CHHBSSSHTTTHHHHHHHHHHHHHCTCGCSHCCEEEEBESS- CS
       HSP70 296 akfeelvedllertlepvekalkdaklkkeeidevvlvGGstRiPkvqelvkelfg.kepsktvnpDeavaiGAAvqagvlsgeeevkdllllDvtpLs 393
                 akfe+l++dl++++ epv+k+l+d++l+k +id+vvlvGGstRiPkvqe+++e+f+ ke+++++npDeava+GAAvq+gvl+g  + +++ll DvtpLs
  EFC39565.1 303 AKFEQLNMDLFKKCFEPVKKVLQDSGLDKAQIDDVVLVGGSTRIPKVQEMLREFFNgKELCRSINPDEAVAYGAAVQGGVLTG--KETKVLLIDVTPLS 399
                 *******************************************************99**************************..9999********** PP

                 EEEEETTTEEEEEESTTCBSSEEEEEEEEESSTTSSSEEEEEEESSSSBGGGSEEEEEEEEECESSCSTTCSEEEEEEEEETTSCEEEEEEETTTCCEE CS
       HSP70 394 lgietlggvmtkliernttiptkksqvfstaadnqtaveievlqgerelvkdnkllgsfeldgippaprGvpqieVtfdidanGiltvsakdketgkee 492
                 lgiet+ggvmtkliern tip kks++fst+adnqtav+i+v++ger+l+kdn+llg+f+l+gippaprGvp+ieVtf+id nGi++vsakd+++gk++
  EFC39565.1 400 LGIETAGGVMTKLIERNSTIPCKKSEIFSTYADNQTAVTIQVFEGERTLTKDNHLLGRFNLEGIPPAPRGVPKIEVTFEIDSNGIMKVSAKDTSSGKTQ 498
                 *************************************************************************************************** PP

                 EEEEECCSS.SBHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..GGGSTHHHH....HHHHHHHHHHHCHTTSSCHHHHHHHHH CS
       HSP70 493 eitieaseg.lseeeiekmvkdaeesaeedkkkkeaieakneaeelvyslekkleee..aekvseaek....ekvesaieeLkeeleeeekeeieakte 584
                 +iti++++g ls+eeie+mvk+a+e+++ dk+ ke+i+akn++e+++y+++++ ++   + k+s+a+k    ++ e+ i++L+++ ++ +k++ie++++
  EFC39565.1 499 NITIKNEQGrLSKEEIEEMVKKAKEMEQFDKELKEKIDAKNQLEAYAYQMKSTADDPnlSGKLSDADKntikKTCEEVINWLDNN-STYSKDDIEKRRK 596
                 *********9*********************************************988999*******55555555666666666.45669******** PP

                 HHHHHHHHHHHHHHH CS
       HSP70 585 elkkvvekiaeklye 599
                 el+  + +i++kly+
  EFC39565.1 597 ELEGKCAPIISKLYQ 611
                 **********99986 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.0     0.028        50       3      50 ..      10      63 ..       8      80 .. 0.64
   2 !   62.1   0.0   2.2e-20   3.9e-17      76     316 ..     126     377 ..     118     384 .. 0.81
   3 ?    2.0   0.8      0.04        72     212     271 ..     477     534 ..     470     539 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.028
                EEEEEE-SSEEEE..EETTTEEEE.......EEES-EEEETTT--EEEESHHHHTTT CS
    MreB_Mbl  3 dlgiDLGtantlv..yvkgkgivl.......nepsvvAikkktkkvlavGeeAkkml 50
                 +giDLGt+   v  y+ ++  ++       + ps vA++ +++    +G+ Ak+ +
  EFC39565.1 10 AIGIDLGTTYSCVgvYMGDNVEIIpndqgnrTTPSYVAFTDEER---LIGDAAKNQV 63
                69******998865588887655522222222477777765544...3466666555 PP

  == domain 2  score: 62.1 bits;  conditional E-value: 2.2e-20
                 HHHHHHHHHHHTSS-S.S--EEEEEE-SS--HHHHHHHHHHHHHTT-SEEEEEEHHHHHHHHTT--TTSSS-EEEEEE-SS-EEEEEEETTEEE..... CS
    MreB_Mbl  76 ellkyfikkvkkkksl.skprvvicvPsgiteverrAvkeaakkaGarevllieeplaAAiGaglpveepsgnmvvdiGggttevavislggiv..... 168
                 +++ + +k+++++    + ++ vi+vP   ++ +r+A k+a   aG +   +i+ep aAAi  gl+ +  +  ++ d+Gggt +v+++ + + v     
  EFC39565.1 126 SMVLTKMKDISEQYLGkQVKKAVITVPAYFNDSQRQATKDAGAIAGLEVLRIINEPTAAAIAYGLNKKGERNVLIFDLGGGTFDVSILNIEDGVfevka 224
                 5555666666665443256789*******************************************************************9987622222 PP

                 EEEEES-SHHHHHHHHHHHH....HHHHSEE--HH..HHHHHHHHH-BSS--HHHH.EEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHHHHH CS
    MreB_Mbl 169 tsksvrvaGdeldeaiikyi....rkkynlliGer..taekikieigsavkeeeee.kmeikGrdlvtglpkevevsseevrealkepvsaiveavkev 260
                 t+   +++G+++d+ ++++     ++ky+  i e+    ++++++   a+ + ++  + +i+   ++ g+   ++++ ++ ++   + +++  e vk+v
  EFC39565.1 225 TAGDTHLGGEDFDNLMVQFCcqefKRKYKKDIQENprALRRLRTACERAKRNLSSAaNASINVDSIMDGIDLDISMTRAKFEQLNMDLFKKCFEPVKKV 323
                 2345789**********9963333788888888751144566666666655544447999*************************************** PP

                 HHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS-.EEE-SSTTTHHHHHHH CS
    MreB_Mbl 261 LektppeLaadivdrgivltGGgallkgldkllseetglp.vkvaedpltcvakGtg 316
                 L++   + a   +d  +vl+GG++ +  ++++l+e ++ +    + +p ++va G++
  EFC39565.1 324 LQDSGLDKA-Q-ID-DVVLVGGSTRIPKVQEMLREFFNGKeLCRSINPDEAVAYGAA 377
                 **9876643.3.44.58999***************9876515567789999999875 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.04
                 S--HHHHEEEEEEEETTTTCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHTS-HHHHHH CS
    MreB_Mbl 212 vkeeeeekmeikGrdlvtglpkevevsseevrealkepvsaiveavkevLektppeLaad 271
                 ++ +++  m+++ +d  +g  +++++++e+ r   ke+++++v+++ke +e+   eL   
  EFC39565.1 477 FEIDSNGIMKVSAKDTSSGKTQNITIKNEQGR-LSKEEIEEMVKKAKE-MEQFDKELKEK 534
                 555666789******************99866.457888999988876.57777777665 PP

>> Hydantoinase_A  Hydantoinase/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.5   0.1   1.7e-05     0.031      24     103 ..     142     222 ..     124     231 .. 0.71
   2 ?   -0.5   0.0      0.33     6e+02     225     282 ..     316     376 ..     299     379 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.7e-05
  Hydantoinase_A  24 kslekrgakarlmvmqsdGglv.sadearkkpvetilSGPaaGvvgaaatsklagekkvItfDmGGTstDvsl..ikdgevev 103
                     k+++k+ ++ + ++ +s+   + +a ++ +  v  i+  P a ++++    +++ge++v+ fD+GG ++Dvs   i+dg +ev
      EFC39565.1 142 KQVKKAVITVPAYFNDSQRQATkDAGAIAGLEVLRIINEPTAAAIAYGL--NKKGERNVLIFDLGGGTFDVSIlnIEDGVFEV 222
                     5555555556666666665443255666666677788889888888888..99*****************9962255666655 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.33
  Hydantoinase_A 225 manavrklsvergldpkeltlvvfGGaG...aqhaaalaeelgvkkvivppyagvlsalGm 282
                       ++v+k++++ gld+ +   vv  G++   + + ++l e ++ k+      +  ++a+G+
      EFC39565.1 316 CFEPVKKVLQDSGLDKAQIDDVVLVGGStriPKVQEMLREFFNGKELCRSINPDEAVAYGA 376
                     5688999*********999988876666344445555555566665555555555555555 PP

>> CPL  CPL (NUC119) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0         3   5.4e+03      96     130 ..      97     132 ..      88     137 .. 0.79
   2 ?   14.0   0.0   2.7e-05     0.048      14      66 ..     562     613 ..     560     642 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 3
         CPL  96 eaiaklakgdlvaeekdeelhliek.pfgsrlLKaL 130
                 + i k+ ++++ + e ++e h++   + +s++L ++
  EFC39565.1  97 KVITKSDEKPYIQVEYKGESHVFTPeQISSMVLTKM 132
                 567888888888888999999988767777887665 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 2.7e-05
         CPL  14 sgrdgryfspeviklLkegdelakktSKKdaevRrkELleaispallsaiakn 66 
                 s  d++ +++   ++++  d+++ + SK d e RrkEL  +++p + ++ ++ 
  EFC39565.1 562 SDADKNTIKKTCEEVINWLDNNS-TYSKDDIEKRRKELEGKCAPIISKLYQQG 613
                 5678889999999999999**99.9*******************988776655 PP

>> EAP30  EAP30/Vps36 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.0     0.049        87      29      67 ..     234     270 ..     226     310 .. 0.80
   2 ?   10.6   0.5   0.00013      0.24      29      68 ..     512     550 ..     483     596 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.049
       EAP30  29 qdleallakfkesLvklaekhkakiksdpafraqftkmc 67 
                 +d ++l+ +f    +++ +k+k++i+++p   ++ ++ c
  EFC39565.1 234 EDFDNLMVQFCC--QEFKRKYKKDIQENPRALRRLRTAC 270
                 577888888887..99*************9777766644 PP

  == domain 2  score: 10.6 bits;  conditional E-value: 0.00013
       EAP30  29 qdleallakfkesLvklaekhkakiksdpafraqftkmca 68 
                 +++e++ +k+ke ++++ +++k+ki ++++ +a   +m +
  EFC39565.1 512 EEIEEMVKKAKE-MEQFDKELKEKIDAKNQLEAYAYQMKS 550
                 689*********.*****************9998888755 PP

>> FtsA  Cell division protein FtsA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0065        12       1      32 [.      11      40 ..      11     171 .. 0.86
   2 ?    4.5   0.0     0.025        46       4      89 ..     202     360 ..     199     379 .. 0.59
   3 ?   -0.5   0.0      0.96   1.7e+03      40      52 ..     513     525 ..     393     611 .. 0.69

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0065
                EEEEE-SSSEEEEEEETTEEEEEEEES-.-HHH CS
                xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxx RF
        FtsA  1 alvDiGagktdvavaedgalvhlrvigv.ggng 32
                +++D+G++ ++v v+ ++   ++++i+  +gn 
  EFC39565.1 11 IGIDLGTTYSCVGVYMGD---NVEIIPNdQGNR 40
                58***************7...888888765554 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.025
                 EE-SSSEEEEEEETTEEEE.....EEEES-....-HHHHHHH......................HHHHHT--HHHHHHHHHHH--S--........... CS
                 xxxxxxxxxxxxxxxxxxx.....xxxxxx....xxxxxxxx......................xxxxxxxxxxxxxxxxxxxxxxxx........... RF
        FtsA   4 DiGagktdvavaedgalvh.....lrvigv....ggngitkd......................iakalrtaveeAerikikyGsala........... 60 
                 D+G+g+ dv++++ +  v+               gg+ +++                       + + lrta e A+r   + +   +           
  EFC39565.1 202 DLGGGTFDVSILNIEDGVFevkatA----GdthlGGEDFDNLmvqfccqefkrkykkdiqenprALRRLRTACERAKRNLSSAA---Nasinvdsimdg 293
                 7777777777777654332333231....1223344444444555555555555666677766666777777777777773322...223355555555 PP

                 ...EEEEEHHHHH...........................................GGGGSTTHHHHHHHHHT-. CS
                 ...xxxxxxxxxx...........................................xxxxxxxxxxxxxxxxxxx RF
        FtsA  61 ...ekeigrkels...........................................ggsalpnleelaeralspk 89 
                    +                                                    g++ +p+++e++++ ++ k
  EFC39565.1 294 idlD--------IsmtrakfeqlnmdlfkkcfepvkkvlqdsgldkaqiddvvlvgGSTRIPKVQEMLREFFNGK 360
                 5441........044444455666777777777888888888888888888889999999999999999998543 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.96
                 HHT--HHHHHHHH CS
                 xxxxxxxxxxxxx RF
        FtsA  40 alrtaveeAerik 52 
                  + + v++A++++
  EFC39565.1 513 EIEEMVKKAKEME 525
                 3333344444444 PP

>> DDR  Diol dehydratase reactivase ATPase-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.1   0.00026      0.47     132     166 ..     195     228 ..     170     231 .. 0.81
   2 ?    1.6   0.0     0.062   1.1e+02     273     296 ..     332     355 ..     307     364 .. 0.82
   3 ?   -2.0   0.2      0.77   1.4e+03      84     113 ..     513     541 ..     482     550 .. 0.68

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00026
         DDR 132 ekplailDlGaGstDaalieeegevkavhlAGAGe 166
                 e+++ i DlG+G+ D ++++ e+ v  v  A AG+
  EFC39565.1 195 ERNVLIFDLGGGTFDVSILNIEDGVFEVK-ATAGD 228
                 56799***************999998864.77776 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.062
         DDR 273 rdidfvvlvGgsalDfEipelvtd 296
                  +id vvlvGgs+    ++e++ +
  EFC39565.1 332 AQIDDVVLVGGSTRIPKVQEMLRE 355
                 5899********988888888766 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 0.77
         DDR  84 glaamvktdklqmqkiaeeleeelgvkvev 113
                  + +mvk +  +m++  +el+e+++ k ++
  EFC39565.1 513 EIEEMVK-KAKEMEQFDKELKEKIDAKNQL 541
                 4667774.4557888888888887777665 PP

>> BcrAD_BadFG  BadF/BadG/BcrA/BcrD ATPase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0    0.0023         4       1      50 [.      11      61 ..      11      91 .. 0.94
   2 ?    3.3   0.0     0.027        49     202     265 ..     320     378 ..     266     380 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0023
                 EEEEE-SS.EEEEEEEETTTEEEEEEEE--TTS-HHH.........HHHHH CS
  BcrAD_BadFG  1 vGiDgGsT.ttkavlmdekgevlgrgitnsanlesvrfeaaekvleealte 50
                 +GiD+G+T ++  v m ++ e++ + + n +  + v f++ e+ + +a ++
   EFC39565.1 11 IGIDLGTTySCVGVYMGDNVEIIPNDQGNRTTPSYVAFTDEERLIGDAAKN 61
                 7*******889**********************************999875 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.027
                  HHHHHHHHHHTT---SS.EEEESGGGG-HHHHHHH.....HHHH-S-EE--GGGGGHHHHHHHH CS
  BcrAD_BadFG 202 ialrvialisrsggvtdevtltGGvakneaavkelrklvkenygevkininpdsiytgalGAal 265
                  +++ +       +++ d+v+l+GG  +  + v   ++++ e +++++   ++ ++ + a GAa+
   EFC39565.1 320 VKKVLQDSGLDKAQI-DDVVLVGGSTRI-PKV---QEMLREFFNGKELCRSINPDEAVAYGAAV 378
                  444444444444445.339999999999.434...34478888888888999999999999985 PP

>> Cys_rich_FGFR  Cysteine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   1.6    0.0079        14       3      30 ..     245     272 ..     244     275 .. 0.96
   2 ?    5.0   0.1     0.016        28      10      39 ..     544     576 ..     538     608 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0079
  Cys_rich_FGFR   3 CkqlllrlqeevaeDykldpkLqkaCkd 30 
                    C++ ++++++++ e+ ++ + L +aC++
     EFC39565.1 245 CQEFKRKYKKDIQENPRALRRLRTACER 272
                    **************************96 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.016
  Cys_rich_FGFR  10 l...qeevaeDykldpkLqkaCkddiekfCsdi 39 
                    +   ++  a+D +l+ kL++a k+ i+k C+++
     EFC39565.1 544 YayqMKSTADDPNLSGKLSDADKNTIKKTCEEV 576
                    4445778899********************874 PP

>> Erp_C  Erp protein C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0       6.3   1.1e+04      34      48 ..      41      55 ..      39      59 .. 0.83
   2 ?   -2.8   0.0       3.2   5.7e+03     110     125 ..     310     325 ..     254     328 .. 0.58
   3 ?    7.9   8.3    0.0016       2.8      44     131 ..     498     587 ..     478     593 .. 0.79

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 6.3
       Erp_C 34 tgpvyddftdgnkai 48
                t p y  ftd+++ i
  EFC39565.1 41 TTPSYVAFTDEERLI 55
                7899*****998766 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 3.2
       Erp_C 110 leklkskleevkkylk 125
                 ++ +k  +e vkk l+
  EFC39565.1 310 MDLFKKCFEPVKKVLQ 325
                 2333444445555544 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.0016
       Erp_C  44 gnkaiyktwgdledeedeglgkllkelsdtrdelrtklnegnk..ayivlekepklkenvnvseikedleklkskleevkkylkdedkfe 131
                 +n +i++  g l +ee e++ k  ke+ +  +el+ k++  n+  ay  + k      n++      d + +k   eev ++l++++ + 
  EFC39565.1 498 QNITIKNEQGRLSKEEIEEMVKKAKEMEQFDKELKEKIDAKNQleAYAYQMKSTADDPNLSGKLSDADKNTIKKTCEEVINWLDNNSTYS 587
                 678899999******************************9997335555554443333443333445677799************99874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (650 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1963  (0.109487); expected 358.6 (0.02)
Passed bias filter:                      874  (0.0487478); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.85u 0.36s 00:00:01.21 Elapsed: 00:00:00.55
# Mc/sec: 3565.65
//
Query:       EFC39566.1  [L=280]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      4e-20   72.1   0.0    7.3e-20   71.2   0.0    1.4  1  DDE_3        DDE superfamily endonuclease
  ------ inclusion threshold ------
      0.044   12.9   0.0      0.072   12.1   0.0    1.3  1  GHL13        Hypothetical glycosyl hydrolase family 13
       0.14   12.3   0.0        1.8    8.7   0.1    2.2  1  Hydrolase_6  Haloacid dehalogenase-like hydrolase


Domain annotation for each model (and alignments):
>> DDE_3  DDE superfamily endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.2   0.0   1.2e-23   7.3e-20       2     137 ..     105     242 ..     104     246 .. 0.91

  Alignments for each domain:
  == domain 1  score: 71.2 bits;  conditional E-value: 1.2e-23
       DDE_3   2 vvfiDEsgfqlgt.vrrrawakkGkrer.leeygrrgrvnligaldekgglafv....tfeetlnaedfaeflerlletalqakkivlilDnasiHkse 94 
                 ++fiDEs+++ ++  rrr+ + kG+ +r  + + +++r ++i+ +++  g +++    t+e+ +++ +f +f+++l++ +++    v ++Dn s+H++e
  EFC39566.1 105 LFFIDESTVTYTDlARRRGHSLKGTPARnSSHHVSNKRFSIIACINRLVGVVYCevidTTEKGVDQIIFSNFMDTLKHLIPK--DKVCVMDNSSVHNKE 201
                 89****99999999*************98999999************9987775333367888999****************..68899********** PP

       DDE_3  95 slrelveeeadrlellylPpySPelNpiEivwsklkrellkrr 137
                 +l++ ++e  +++++l+  +ySP++  iE ++s+lk+el++++
  EFC39566.1 202 TLVDSMKE--AGIHVLFQSRYSPDYTLIEFCFSWLKSELKREE 242
                 ********..*****************************9954 PP

>> GHL13  Hypothetical glycosyl hydrolase family 13
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   1.2e-05     0.072     172     232 ..      40     100 ..      32     115 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.2e-05
                 TT--S-HHHHHTSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH.-TT-EEEEEEEHHHHHSG CS
       GHL13 172 aglpesiaeiradpellakwtklktkalidfteelakrvrayr.kpelktaRnlyaevvlnp 232
                 + l++si+ei  ++  l++ +++ktk l  +t++  + +++yr kp+++  R ly+e vl  
  EFC39566.1  40 QELQQSIKEIFGNEISLSQLSDVKTKILN-ITNKKVELLSNYRkKPHIQQHRKLYRELVLGF 100
                 5799*********************9875.666666677777669************99965 PP

>> Hydrolase_6  Haloacid dehalogenase-like hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.1   0.00031       1.8      25      80 ..      66     124 ..      63     230 .. 0.87

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00031
                  HHHHTT-EEEEEE---SS-HHHHHHHH.HH..TT----GGGEEEHHHHHHHHHHHHSXX CS
  Hydrolase_6  25 alraagkpvvllTNnsskseeeyakkl.ek..lgvditeeqvvtsataaaeylkkrkad 80 
                  +l+ ++k+v ll+N  +k+  + + kl ++  lg++i++  ++  +t+++  l++r+++
   EFC39566.1  66 ILNITNKKVELLSNYRKKPHIQQHRKLyRElvLGFEIDDLFFIDESTVTYTDLARRRGH 124
                  577789*************9999999988856699999999999999999999987764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       701  (0.0390987); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.31s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1594.47
//
Query:       EFC39567.1  [L=347]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.3e-31  105.9   8.5    0.00066   19.5   0.0    8.8  9  LRR_6       Leucine Rich repeat
    1.5e-23   82.3   8.3      2e-10   40.3   0.5    5.3  5  LRR_8       Leucine rich repeat
    1.8e-15   56.8  14.1    6.8e-05   23.2   0.2    6.6  6  LRR_4       Leucine Rich repeats (2 copies)
    1.3e-06   28.1   3.1        4.9    8.1   0.0    7.0  8  LRR_1       Leucine Rich Repeat
    1.2e-05   24.9   1.6       0.19   11.2   0.1    3.7  4  LRR_9       Leucine-rich repeat
    0.00085   19.3   3.0      0.014   15.3   0.1    3.1  3  LRR_5       BspA type Leucine rich repeat region (6 copies)
  ------ inclusion threshold ------
      0.015   15.1   1.2        1.3    8.9   0.7    2.8  3  FTH         FTH domain
      0.094   12.6   0.2       0.18   11.8   0.2    1.5  1  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       5.1   1.1e+04       4      11 ..      98     105 ..      96     106 .. 0.74
   2 !   17.1   0.0   1.8e-06    0.0041       5      21 ..     145     161 ..     142     163 .. 0.93
   3 !   16.0   0.0     4e-06     0.009       3      24 .]     167     188 ..     165     188 .. 0.94
   4 !   11.6   0.0    0.0001      0.23       5      24 .]     193     212 ..     190     212 .. 0.95
   5 !   16.3   0.0   3.3e-06    0.0073       4      24 .]     216     236 ..     213     236 .. 0.93
   6 ?    1.8   0.0      0.15   3.3e+02      14      24 .]     250     260 ..     239     260 .. 0.74
   7 !    9.6   0.1   0.00046         1      12      23 ..     272     283 ..     263     284 .. 0.85
   8 !   19.5   0.0   2.9e-07   0.00066       5      24 .]     289     308 ..     286     308 .. 0.94
   9 !   10.0   0.0   0.00034      0.77       4      23 ..     312     331 ..     309     331 .. 0.91

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 5.1
       LRR_6   4 hLteLdLs 11 
                  LteL++ 
  EFC39567.1  98 QLTELQID 105
                 59999875 PP

  == domain 2  score: 17.1 bits;  conditional E-value: 1.8e-06
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 LteL +s+N++gDeGa+
  EFC39567.1 145 LTELKISSNKFGDEGAK 161
                 9**************97 PP

  == domain 3  score: 16.0 bits;  conditional E-value: 4e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 t Lt+L++++N Ig  Ga+aL+
  EFC39567.1 167 TQLTKLEIKSNRIGKLGAKALC 188
                 67*******************8 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 0.0001
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L+eL +s N +g +Ga++++
  EFC39567.1 193 LKELRISENALGASGAKSIS 212
                 9****************996 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 3.3e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                  Lt+L + +N++g eGa+a++
  EFC39567.1 216 QLTTLTIDYNQLGPEGAKAIS 236
                 59*****************96 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.15
       LRR_6  14 dIgDeGaeaLa 24 
                 +Ig +Ga++++
  EFC39567.1 250 QIGAAGAKSIS 260
                 7*******996 PP

  == domain 7  score: 9.6 bits;  conditional E-value: 0.00046
       LRR_6  12 gNdIgDeGaeaL 23 
                 gN IgD+Ga+a+
  EFC39567.1 272 GNAIGDKGAKAI 283
                 8**********9 PP

  == domain 8  score: 19.5 bits;  conditional E-value: 2.9e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L+Ls+N+Ig eGa+a++
  EFC39567.1 289 LTSLHLSFNHIGFEGAKAIS 308
                 9*****************96 PP

  == domain 9  score: 10.0 bits;  conditional E-value: 0.00034
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +L++L+++ N ++ eGa+ L
  EFC39567.1 312 NLRYLNMTTNPLSSEGAQLL 331
                 8****************876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0      0.26   5.8e+02      44      56 ..      92     104 ..      82     106 .. 0.73
   2 !    6.0   0.0    0.0044       9.8       2      36 ..     120     154 ..     119     160 .. 0.79
   3 !   40.3   0.5   8.9e-14     2e-10       2      61 .]     168     227 ..     167     227 .. 0.98
   4 !   28.0   0.0   6.1e-10   1.4e-06       1      61 []     239     299 ..     239     299 .. 0.99
   5 !   22.5   0.1   3.2e-08   7.2e-05      18      61 .]     280     323 ..     273     323 .. 0.87

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.26
                 GGTT--S-.EEE- CS
       LRR_8  44 afsgLpsLrsLdL 56 
                 +f+ +++L++L +
  EFC39567.1  92 VFEKMNQLTELQI 104
                 5677777777765 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.0044
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNl 36 
                 +Lt+L++++    + + +    +++L++L++s+N+
  EFC39567.1 120 QLTKLSVCSCTEDVEQVKLIGEMKQLTELKISSNK 154
                 67788887777777777777779999999999997 PP

  == domain 3  score: 40.3 bits;  conditional E-value: 8.9e-14
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L + +Nr+ +l+ +a  +l+ Lk+L +s+N l    ++++s+L++L+ L++++N+L
  EFC39567.1 168 QLTKLEIKSNRIGKLGAKALCNLKELKELRISENALGASGAKSISQLKQLTTLTIDYNQL 227
                 8*********************************************************98 PP

  == domain 4  score: 28.0 bits;  conditional E-value: 6.1e-10
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 pnLt+L++++ ++ + + ++ +++++L +L+   N +    ++a+  +++L+sL+Ls N++
  EFC39567.1 239 PNLTNLSICSDQIGAAGAKSISKMKQLLTLSADGNAIGDKGAKAIGEMKQLTSLHLSFNHI 299
                 79*********************************************************98 PP

  == domain 5  score: 22.5 bits;  conditional E-value: 3.2e-08
                 TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  18 deaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  +a   +++L++L+Ls N + +  ++a+s L++Lr+L+++ N+L
  EFC39567.1 280 AKAIGEMKQLTSLHLSFNHIGFEGAKAISELKNLRYLNMTTNPL 323
                 567778999*************99**************999987 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.2   0.1    0.0015       3.4       2      35 ..     120     154 ..      90     162 .. 0.80
   2 !   18.4   0.1   9.5e-07    0.0021       1      33 [.     167     201 ..     167     207 .. 0.89
   3 !   13.0   0.2   4.6e-05       0.1       2      37 ..     192     228 ..     191     231 .. 0.83
   4 !    6.8   0.2    0.0044       9.8       2      35 ..     216     250 ..     215     258 .. 0.74
   5 ?    3.9   0.1     0.035        79       1      33 [.     239     273 ..     239     279 .. 0.78
   6 !   23.2   0.2     3e-08   6.8e-05       1      37 [.     287     324 ..     287     332 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0015
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnl 35 
                 +L++L+  + +  d++   l + +++L+eL +s+N +
  EFC39567.1 120 QLTKLSVCS-CTEDVEQvkLIGeMKQLTELKISSN-K 154
                 566666666.4446666554455*********999.4 PP

  == domain 2  score: 18.4 bits;  conditional E-value: 9.5e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 ++L++L + +N++ +++   l +l+ LkeL +s+N
  EFC39567.1 167 TQLTKLEIKSNRIGKLGAkaLCNLKELKELRISEN 201
                 68****************88667*********999 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 4.6e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                  L++L +s N l   +   +++l++L++L++  N +++
  EFC39567.1 192 ELKELRISENALGASGAksISQLKQLTTLTIDYN-QLG 228
                 79***********766676557*********667.775 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0044
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 +L++L +  Nql   +   ++ +pnL+ L++ +  +
  EFC39567.1 216 QLTTLTIDYNQLGPEGAkaISEIPNLTNLSICSD-Q 250
                 7999999999999444455445*******98443.4 PP

  == domain 5  score: 3.9 bits;  conditional E-value: 0.035
                 SS--EEE--.SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLs.nNqltdipl..leklpnLkeLdLsgN 33 
                 pnL++L++  + q+   +   ++k+++L +L+  gN
  EFC39567.1 239 PNLTNLSICsD-QIGAAGAksISKMKQLLTLSADGN 273
                 78999999977.999888876667999999998777 PP

  == domain 6  score: 23.2 bits;  conditional E-value: 3e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L+Ls N++   +   ++ l+nL++L+++ N +++
  EFC39567.1 287 KQLTSLHLSFNHIGFEGAkaISELKNLRYLNMTTN-PLS 324
                 58************666676445*********667.654 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0         8   1.8e+04      14      21 ..      51      58 ..      37      59 .. 0.71
   2 ?   -2.7   0.0       7.9   1.8e+04       2      10 ..     121     129 ..     120     132 .. 0.81
   3 ?    2.1   0.0      0.21   4.6e+02       1      17 [.     144     160 ..     144     166 .. 0.79
   4 ?    3.9   0.0     0.052   1.2e+02       2      23 .]     169     190 ..     168     190 .. 0.93
   5 ?    0.1   0.0       0.9     2e+03       2      20 ..     193     211 ..     192     214 .. 0.74
   6 ?    1.8   0.0      0.26   5.7e+02       2      13 ..     217     235 ..     216     261 .. 0.75
   7 ?    4.3   0.0     0.038        86       1      17 [.     288     304 ..     288     310 .. 0.74
   8 !    8.1   0.0    0.0022       4.9       1      22 [.     312     333 ..     312     334 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 8
       LRR_1 14 glppnsfq 21
                ++++++f+
  EFC39567.1 51 SKLSACFS 58
                46777886 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 7.9
       LRR_1   2 LrhLdLsnn 10 
                 L++L ++++
  EFC39567.1 121 LTKLSVCSC 129
                 888999888 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.21
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L +s+n +++ ++
  EFC39567.1 144 QLTELKISSNKFGDEGA 160
                 599*******9977665 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.052
       LRR_1   2 LrhLdLsnnpllglppnsfqnL 23 
                 L++L + +n+++ l++ +++nL
  EFC39567.1 169 LTKLEIKSNRIGKLGAKALCNL 190
                 99**************999997 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.9
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L++L +s n l+  ++ s+
  EFC39567.1 193 LKELRISENALGASGAKSI 211
                 9******998865555555 PP

  == domain 6  score: 1.8 bits;  conditional E-value: 0.26
       LRR_1   2 LrhLdLsnnpl.......l 13 
                 L++L + +n+l       +
  EFC39567.1 217 LTTLTIDYNQLgpegakaI 235
                 8999999999855544442 PP

  == domain 7  score: 4.3 bits;  conditional E-value: 0.038
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L+Ls n+++  ++
  EFC39567.1 288 QLTSLHLSFNHIGFEGA 304
                 599********965555 PP

  == domain 8  score: 8.1 bits;  conditional E-value: 0.0022
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nLr+L+++ npl++ +++ +qn
  EFC39567.1 312 NLRYLNMTTNPLSSEGAQLLQN 333
                 8***********9999888887 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0     0.089     2e+02      89     124 ..      95     130 ..      74     137 .. 0.66
   2 !   11.2   0.1   8.6e-05      0.19      56     130 ..     135     208 ..     129     227 .. 0.62
   3 !    5.4   0.0    0.0051        11      62     126 ..     213     276 ..     207     281 .. 0.86
   4 !    7.3   0.0    0.0014       3.1      63     142 ..     262     339 ..     255     345 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.089
       LRR_9  89 nleelvltnnelqeladldPlaslkklellsllknp 124
                 ++++l   +    +  dl+ +++lk+l+ ls+ +++
  EFC39567.1  95 KMNQLTELQIDWVREIDLKRIVDLKQLTKLSVCSCT 130
                 555443222232334578899999999999998875 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 8.6e-05
       LRR_9  56 kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkke 130
                 ++  +  +k+l  l +++n+    + ++   + +l++l + +n++ +l+  + l +lk+l+ l + +n++ +   
  EFC39567.1 135 QVKLIGEMKQLTELKISSNKFGDEGAKIIGGMTQLTKLEIKSNRIGKLGA-KALCNLKELKELRISENALGASGA 208
                 55555567777777777777777777777777777777777777777776.777777777777777776655443 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0051
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                  lk+l tl ++ n++   + +    +Pnl++l + ++++   +  + + ++k+l +ls   n++ 
  EFC39567.1 213 QLKQLTTLTIDYNQLGPEGAKAISEIPNLTNLSICSDQIGAAGA-KSISKMKQLLTLSADGNAIG 276
                 689999********99999999999**************99887.89999999999998777765 PP

  == domain 4  score: 7.3 bits;  conditional E-value: 0.0014
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkql 142
                 +k+l tl+ + n i   + +    + +l++l l+ n++   +  + + +lk+l++l + +np++++   +l    kl++l
  EFC39567.1 262 MKQLLTLSADGNAIGDKGAKAIGEMKQLTSLHLSFNHIGFEGA-KAISELKNLRYLNMTTNPLSSEGA-QLLQNMKLPKL 339
                 788888888999998777777777889999*******986665.99****************987643.33444555555 PP

>> LRR_5  BspA type Leucine rich repeat region (6 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.24   5.3e+02      75      94 ..      92     110 ..      49     142 .. 0.57
   2 !   15.3   0.1   6.3e-06     0.014      12     101 ..     168     261 ..     159     276 .. 0.65
   3 ?    1.9   0.2     0.088     2e+02      47     110 ..     277     342 ..     236     347 .] 0.57

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.24
       LRR_5  75 aFsncsslkeitlpsnltti 94 
                 +F+++++l+e+++   +++i
  EFC39567.1  92 VFEKMNQLTELQI-DWVREI 110
                 4444555555554.334444 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 6.3e-06
       LRR_5  12 nltsitipss.vtsIgeyaFsnctslksitlpss.lteigsyaFsncssltsitip.ssltsigeyaFsncsslkeitlps.nlttigssaFsn 101
                 +lt+++i+s+ + ++g +a +n ++lk++ ++++ l   g ++ s+ ++lt++ti  ++l   g +a s++ +l+++++ s ++   g +++s+
  EFC39567.1 168 QLTKLEIKSNrIGKLGAKALCNLKELKELRISENaLGASGAKSISQLKQLTTLTIDyNQLGPEGAKAISEIPNLTNLSICSdQIGAAGAKSISK 261
                 6677777754366777777777777777777765577777777777777777777524677777777777777777777542355555555555 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.088
       LRR_5  47 eigsyaFsncssltsitip.ssltsigeyaFsncsslkeitlpsn.lttigssaFsncslesitip 110
                   g +a  ++++lts+ ++ +++   g +a s+ ++l+ +++ +n l++ g +  +n++l +++i 
  EFC39567.1 277 DKGAKAIGEMKQLTSLHLSfNHIGFEGAKAISELKNLRYLNMTTNpLSSEGAQLLQNMKLPKLIID 342
                 444555556666666666523444445667777777777777666677777777777777777665 PP

>> FTH  FTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   0.7   0.00056       1.3      42     107 ..      97     161 ..      76     179 .. 0.91
   2 ?    3.4   0.0     0.027        61      39     110 ..     188     260 ..     168     271 .. 0.73
   3 ?   -1.9   0.0       1.1   2.5e+03      83     111 ..     305     333 ..     286     338 .. 0.71

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00056
         FTH  42 gtLeeIelsseeeeeefeelveleQWKnAkklkiessklssfpiehlfhFeefeikldkfsvedai 107
                 ++L e+++ ++ +e +++++v+l+Q  +   ++++ +  + + i ++ +++e++i+ +kf  e a+
  EFC39567.1  97 NQLTELQI-DWVREIDLKRIVDLKQLTKLSVCSCTEDVEQVKLIGEMKQLTELKISSNKFGDEGAK 161
                 679999*9.999***************************999*****************9887776 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.027
         FTH  39 fkagtLeeIelsseeeeeefeelveleQWKnAkklkiessklssf...piehlfhFeefeikldkfsvedaikir 110
                 ++ + L+e+++  +e+        +  Q K+  +l+i+ + l  +    i ++ ++++++i+ d++ +  a+ i 
  EFC39567.1 188 CNLKELKELRI--SENALGASGAKSISQLKQLTTLTIDYNQLGPEgakAISEIPNLTNLSICSDQIGAAGAKSIS 260
                 45566888888..66666666666777778888888888777555555888888888888888888777776665 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.1
         FTH  83 fpiehlfhFeefeikldkfsvedaikird 111
                 + i +l ++  ++++++ +s+e a  + +
  EFC39567.1 305 KAISELKNLRYLNMTTNPLSSEGAQLLQN 333
                 36788888888888888888888877766 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   7.9e-05      0.18       6      36 ..      15      48 ..      15      53 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 7.9e-05
  F-box-like  6 dEiLlqIFsyL.ppsd..LlrlalVCrrWrrval 36
                d+++ +I+s+L ++    L+ ++l +++W +v+ 
  EFC39567.1 15 DDVCYEILSFLgDDWKfvLTKCTLISKQWLEVIK 48
                678999*****66663559************995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (347 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       424  (0.0236488); expected 358.6 (0.02)
Passed bias filter:                      255  (0.0142228); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.55u 0.32s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2170.49
//
Query:       EFC39568.1  [L=424]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.1    8.3  10.1        3.9    7.4   7.2    2.7  2  DUF3557   Domain of unknown function (DUF3557)


Domain annotation for each model (and alignments):
>> DUF3557  Domain of unknown function (DUF3557)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   7.2   0.00022       3.9      24     121 ..      61     178 ..      51     187 .. 0.87
   2 ?   -2.3   0.0      0.21   3.8e+03      58      90 ..     246     282 ..     228     300 .. 0.60

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00022
     DUF3557  24 nklsisskgilriPsnlklkvknLeisgserdkilealrplldesslplkslevedt.................kvsnldhpivqnaklLilngeytnp 105
                 + +s s++ i + ++nl +k k+++is++ + ++++  ++ +++s+   +++e+  +                  ++++ hp+++++ + +l++e    
  EFC39568.1  61 KLFSNSQNLIAKQVENLLFKWKEVDISHETSIETFNHQQSQFQNSEREYSQIEMDAEffksrkqsnfelsnqmeANKKIPHPLFEKSSISSLHNEPNEK 159
                 45888999999*******************************************999999999999999988888889999999999999999997776 PP

     DUF3557 106 rn...slllalknkrvhie 121
                  +   + l++++++r++i 
  EFC39568.1 160 AKlqvEILQRMEKQRLNIL 178
                 6689999999999999987 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.21
     DUF3557  58 lealrplldesslplkslevedt....kvsnldhpiv 90 
                  ++l+p+l++s+ p   ++ + +     +++ +h+ +
  EFC39568.1 246 RSMLQPYLQKSNQPQFYINGNLEneifFNTMYNHDEI 282
                 5677888888886654444333344553444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (424 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1428  (0.0796475); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.24s 00:00:00.78 Elapsed: 00:00:00.42
# Mc/sec: 3024.73
//
Query:       EFC39569.1  [L=166]
Description: 40S ribosomal protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-32  111.2   3.2    1.1e-31  108.9   1.4    2.3  2  Ribosomal_S17_N  Ribosomal_S17 N-terminal
    5.9e-26   90.4   2.4    8.8e-26   89.8   2.4    1.3  1  Ribosomal_S17    Ribosomal protein S17


Domain annotation for each model (and alignments):
>> Ribosomal_S17_N  Ribosomal_S17 N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  108.9   1.4   1.3e-35   1.1e-31       1      69 []       8      83 ..       8      83 .. 0.89
   2 ?    1.8   0.0     0.036   3.2e+02      20      50 ..     103     133 ..      89     148 .. 0.75

  Alignments for each domain:
  == domain 1  score: 108.9 bits;  conditional E-value: 1.3e-35
                     --SSS----SS--------------...........--------TT----GGGGS-----TTSSSSSS----S-EE CS
  Ribosomal_S17_N  1 qterafqkQetvflnkkkskeekkkkkkk.......kryvknvglgfktPkeAiegtYiDkKCPFtGnvsirGriL 69
                     q++rafqkQe+vfl +k+   +k k  k        +r++kn+glgf+tPk+Ai+g+YiDkKCPFtGnvsirGriL
       EFC39569.1  8 QNQRAFQKQESVFLGNKRGLLKKLKDGKItdqerrkVRFFKNIGLGFSTPKTAIQGQYIDKKCPFTGNVSIRGRIL 83
                     89***************7666555544336677888***************************************8 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.036
                      ------....--------TT----GGGGS-- CS
  Ribosomal_S17_N  20 keekkkkkkkkryvknvglgfktPkeAiegt 50 
                       + +kk ++ ++ +knv+  ++   eA eg+
       EFC39569.1 103 LKYEKKYNRYEKRHKNVAAHISPAFEAHEGD 133
                      4555666666889999999888888888875 PP

>> Ribosomal_S17  Ribosomal protein S17
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   89.8   2.4   9.9e-30   8.8e-26       1      68 []      85     153 ..      85     153 .. 0.98

  Alignments for each domain:
  == domain 1  score: 89.8 bits;  conditional E-value: 9.9e-30
                    EEEEE--STTEEEEEEEEEEEETTTTEEEEEEEEEEEE-TTTS.--TT-EEEEEEECECSSSEEEEEEE CS
  Ribosomal_S17   1 GvVvsdkmdkTvvVrverlvkhpkykkyvkrrkkylahdenns.vkvGDiVrieecrPlSktkrfvvve 68 
                    GvV s+km +T +Vr+++l++ +ky++y+kr+k++ ah ++ + +++GD+V i+ecrPlSkt+rf+vv+
     EFC39569.1  85 GVVKSHKMARTLIVRRDYLKYEKKYNRYEKRHKNVAAHISPAFeAHEGDVVVIGECRPLSKTVRFNVVK 153
                    99****************************************99***********************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (166 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       794  (0.0442858); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.42u 0.26s 00:00:00.68 Elapsed: 00:00:00.41
# Mc/sec: 1204.63
//
Query:       EFC39570.1  [L=214]
Description: hypothetical protein NAEGRDRAFT_81232 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0007   20.1   1.9      0.027   15.0   0.1    2.3  2  DUF4773   Domain of unknown function (DUF4773)


Domain annotation for each model (and alignments):
>> DUF4773  Domain of unknown function (DUF4773)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.2    0.0024        43      15      51 ..      62      98 ..      59     106 .. 0.86
   2 !   15.0   0.1   1.5e-06     0.027      29      98 ..     108     182 ..      99     191 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0024
     DUF4773 15 lnlkalklkkkvCvnvkynpedlslkvkvslnekvll 51
                l+ k +k k+  C   ++++++ +++++vs+n++ + 
  EFC39570.1 62 LKSKLMKAKEASCHYSNISKDQKAFECDVSVNQTIVG 98
                667889999***********************98875 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 1.5e-06
     DUF4773  29 nvkynpedlslkvkvslnekvllkktisakn.pppiCvpl..leklakvCvrlsdik..akeenlkaCleleakl 98 
                 +v+++ +++s  v++ +++ v+++k+++ ++ + piCv    l kl+++C+ +s++k  +++e ++a ++l++k+
  EFC39570.1 108 SVDVDLKTESAIVQIVFDGMVIYNKNLTIADlTVPICVTPaaLDKLISLCLDFSQLKfdVNKECFRAFVSLDLKI 182
                 4556667788899**************9655278***88778889**********99544566677777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (214 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       634  (0.0353617); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.32s 00:00:00.80 Elapsed: 00:00:00.48
# Mc/sec: 1331.69
//
Query:       EFC39571.1  [L=566]
Description: hypothetical protein NAEGRDRAFT_59227 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-12   45.9  12.5    3.7e-07   29.7   4.1    2.2  2  Fuseless  Fuseless
  ------ inclusion threshold ------
      0.077   12.5   0.1      0.077   12.5   0.1    2.2  2  DUF1700   Protein of unknown function (DUF1700)


Domain annotation for each model (and alignments):
>> Fuseless  Fuseless
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   1.2   1.6e-08   0.00014       3      36 ..     340     374 ..     336     423 .. 0.57
   2 !   29.7   4.1   4.1e-11   3.7e-07     242     299 .]     450     511 ..     444     511 .. 0.90

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 1.6e-08
    Fuseless   3 rllDflislviitplvvlyWrgtwllldiy.lfpd 36 
                  +l++l+ +++i  +v+++Wrgtw l++ y +f +
  EFC39571.1 340 DVLEILVTILLINFCVASFWRGTWVLIESYvVFGG 374
                 56777777777777777777777777777754432 PP

  == domain 2  score: 29.7 bits;  conditional E-value: 4.1e-11
    Fuseless 242 vledafllvsfigvvnvWrGlwnlldlyllp....dkpklsawlthvigflllvllnasnsl 299
                 ++e + ++++++g v +WrG++ ++d+y+ p    +++ +s wl+h++g++++++  + nsl
  EFC39571.1 450 IVEKVHVYIVAVGCVFCWRGVFGIWDSYIAPymdkENQIISGWLSHGLGLVFVLIFGCMNSL 511
                 7899**********************9888744335899*******************9997 PP

>> DUF1700  Protein of unknown function (DUF1700)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   8.5e-06     0.077      79     171 ..     327     417 ..     295     421 .. 0.72
   2 ?   -0.3   2.6     0.075   6.7e+02      96     158 ..     444     506 ..     437     514 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8.5e-06
     DUF1700  79 skailavigLsllnlilvlipliviislvlsllvvalallvsplvllvksllkgfeelslnvfvsigllglGllllivayylvkilykltvky 171
                  +++   ++ + l+++ +l+ +++i + v+s++ ++ +l+ s +v  ++s  ++ + + l ++++ig+ ++G++ l+ ++   + ++ ++ ky
  EFC39571.1 327 KSKVCWNMSFLGLDVLEILVTILLINFCVASFWRGTWVLIESYVVFGGTSPERAAQ-INL-IYLGIGIASVGFFQLLSVVVSNHDVHTILHKY 417
                 34556667777777777888999999999999*99999999988888887665544.443.8**********976666666666666666665 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.075
     DUF1700  96 vlipliviislvlsllvvalallvsplvllvksllkgfeelslnvfvsigllglGllllivay 158
                 +l  l ++  + + ++ v++++   +++ +  s +  +++   ++  +    glGl+++++  
  EFC39571.1 444 ILSFLWIVEKVHVYIVAVGCVFCWRGVFGIWDSYIAPYMDKENQIISGWLSHGLGLVFVLIFG 506
                 2333333334444444455555666666666666666666666699999999***99998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (566 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       990  (0.0552178); expected 358.6 (0.02)
Passed bias filter:                      474  (0.0264376); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.29s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 3487.19
//
Query:       EFC39572.1  [L=392]
Description: hypothetical protein NAEGRDRAFT_81234 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.3e-07   31.2   0.0    5.9e-07   29.9   0.0    1.7  1  RNA_ligase       RNA ligase
  ------ inclusion threshold ------
       0.16   12.2   0.0        0.3   11.3   0.0    1.4  1  Herpes_heli_pri  Herpesvirus helicase-primase complex compone


Domain annotation for each model (and alignments):
>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.9   0.0   6.6e-11   5.9e-07       3     160 ..      72     273 ..      70     276 .. 0.74

  Alignments for each domain:
  == domain 1  score: 29.9 bits;  conditional E-value: 6.6e-11
                 EEEEEE-SSEEEEEEEE.TT.............................................EEEEETTCEBCTTTHHHHHHTHHHHHHHHHHHHH CS
  RNA_ligase   3 vvvtEKlDGtnfriylv.ke.............................................vgvasRsqilpfgeekfkefkrwaaalrkklkek 55 
                 v ++EK+DG+++++    k+                                             + + s+++ +      +++f+  a+   + l++ 
  EFC39572.1  72 VFAQEKIDGSQLSVKRMyKDemelveknsccgrddddeeegdsenvvetpsslpefvkdtdretqLVFRSKRGPI-----GCDTFFGDAVRSVSTLADL 165
                 679***********8876336778888677777777777777777777777777775555555555555555555.....4555666666666688888 PP

                 ..ECCEEEEEEEES.....SS..TT.SS.EEEEEEEEEEECTTBECE--HHHHHHHHHCCT..B..EEEEE.SS..HHHHHCCC...H.HHHTC--EEE CS
  RNA_ligase  56 laneelilyGElig....hsikygg.lpkefyvFdifdirdkeeqrylspdevealakglg..tvpvlyegkfl..aaeellel.l.l.skgnkrEGlV 142
                 l+ +++   GE ++      i yg+  ++ f++F i +    e++ yl+p  +++ a+++g  +  +ly+g  +  +++e+++    + +     EG+V
  EFC39572.1 166 LR-PNWTYRGETVTrlrhTRILYGRiPKHSFVLFEIQN----EKGHYLPPNLIQEEAERIGfeYSQILYQGILDfkKLKEVANNsKsQlGGFAMIEGIV 259
                 88.77*********999555599999889999999994....59*********888888999999***99988876666666668334566779***** PP

                 EEESSSSBETTEBSEEEE CS
  RNA_ligase 143 ikpeselyknkgraifKv 160
                  k    +ykn +  +fK+
  EFC39572.1 260 TK----MYKNGKMSSFKL 273
                 **....555444666665 PP

>> Herpes_heli_pri  Herpesvirus helicase-primase complex component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   3.3e-05       0.3      18      72 ..     248     304 ..     232     315 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3.3e-05
  Herpes_heli_pri  18 desildlleevvslyfknrrsaafWlvPlsfleskpvaP..klpvdclapklfiltk 72 
                      +     ++e +v+ ++kn++ ++f lv +++ e+k ++     +++ l  kl++++k
       EFC39572.1 248 QLGGFAMIEGIVTKMYKNGKMSSFKLVAKQYKETKTKKImkINEFSELDKKLKVIAK 304
                      4455679*************************9996653103468888888888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (392 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1057  (0.0589548); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.25s 00:00:00.77 Elapsed: 00:00:00.42
# Mc/sec: 2792.54
//
Query:       EFC39573.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.081   13.1   0.1        1.9    8.7   0.0    3.0  4  DUF5329   Family of unknown function (DUF5329)


Domain annotation for each model (and alignments):
>> DUF5329  Family of unknown function (DUF5329)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0      0.72   1.3e+04      62      87 ..      14      39 ..      12      42 .. 0.72
   2 ?    8.7   0.0   0.00011       1.9      35      69 ..     197     231 ..     181     250 .. 0.83
   3 ?    0.3   0.0     0.046   8.3e+02      47      90 ..     260     303 ..     253     305 .. 0.77
   4 ?   -2.4   0.0      0.32   5.7e+03      45      57 ..     395     407 ..     379     433 .. 0.66

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 0.72
     DUF5329 62 SsisgkpYqvkcadgkkveskewLke 87
                S ++g++ +   ++++ ++ +++L++
  EFC39573.1 14 SLMTGEEETFTSSGSAGQHRNRYLEK 39
                67778777777777777777777765 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00011
     DUF5329  35 eHLrrKykklekkvktaedFieelAskSsisgkpY 69 
                  HL++ + +++ k+k++++F     s S is +p 
  EFC39573.1 197 LHLKSEWYYMDGKLKSTDSFRLDPTSDSFISTRPI 231
                 6*****************************99985 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.046
     DUF5329  47 kvktaedFieelAskSsisgkpYqvkcadgkkveskewLkeelk 90 
                 ++k++e F+  l     + g++Y  k  +++ + + ++L++ +k
  EFC39573.1 260 QLKDTEGFVYVLDIGCKVNGEEYLPKSFEDQLRVAIQYLQTYIK 303
                 48888999988888888889999888888888888888887666 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 0.32
     DUF5329  45 ekkvktaedFiee 57 
                 +k  k++ +Fi++
  EFC39573.1 395 AKDHKSIGSFIDN 407
                 2335666667765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       759  (0.0423336); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.50
# Mc/sec: 2726.23
//
Query:       EFC39574.1  [L=172]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (172 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       512  (0.0285571); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.49
# Mc/sec: 1048.80
//
Query:       EFC39575.1  [L=597]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.1e-08   33.8   0.0    8.1e-07   29.6   0.0    2.6  2  Methyltransf_11  Methyltransferase domain
    1.2e-07   31.7   0.1    2.3e-07   30.8   0.1    1.5  1  Methyltransf_23  Methyltransferase domain
    7.1e-07   28.1   0.0    1.2e-06   27.4   0.0    1.3  1  Methyltransf_29  Putative S-adenosyl-L-methionine-dependent m
    1.4e-05   25.7   0.0    6.8e-05   23.5   0.0    2.2  2  Methyltransf_25  Methyltransferase domain
    6.5e-05   22.8   0.3    0.00026   20.8   0.0    2.1  3  Methyltransf_31  Methyltransferase domain
     0.0019   19.0   0.1      0.028   15.2   0.0    2.7  3  DIOX_N           non-haem dioxygenase in morphine synthesis N
     0.0036   17.5   4.1        0.3   11.3   0.2    2.8  2  TFIID_NTD2       WD40 associated region in TFIID subunit, NTD
     0.0046   16.5   0.0      0.017   14.7   0.0    1.9  2  Methyltransf_PK  AdoMet dependent proline di-methyltransferas
     0.0077   16.9   0.0      0.033   14.9   0.0    2.2  1  Methyltransf_12  Methyltransferase domain
  ------ inclusion threshold ------
      0.013   15.3   0.8       0.04   13.7   0.8    1.8  1  PRELI            PRELI-like family
      0.024   14.0   0.0      0.052   12.9   0.0    1.5  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family


Domain annotation for each model (and alignments):
>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.6   0.0     5e-10   8.1e-07      46      96 .]     190     241 ..     145     241 .. 0.67
   2 ?    0.9   0.0      0.43   7.1e+02      75      93 ..     391     409 ..     383     410 .. 0.83

  Alignments for each domain:
  == domain 1  score: 29.6 bits;  conditional E-value: 5e-10
                      EETTEECCCT.SS-TT-EEEEEEES-CCC-..CCHHHHHHHHHHHEEEEEEEEE CS
  Methyltransf_11  46 efvvadaekl.pfednsfDlvvssevlhhv..edpekalkeiaRvLkpgGllvi 96 
                      +fv  d  +l  +++ns+Dl++++  lhh    +++ ++ke++R+L+p+G++++
       EFC39575.1 190 KFVPYD--QLhDIPSNSVDLITCFIGLHHYtdTELNLYMKELKRILRPNGIFIL 241
                      344444..443899****************9989*****************985 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.43
                      CCHHHHHHHHHHHEEEEEE CS
  Methyltransf_11  75 edpekalkeiaRvLkpgGl 93 
                      + ++ +++ + Rv+k +Gl
       EFC39575.1 391 KFWKLFFNSCTRVMKRDGL 409
                      668889***********96 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   0.1   1.4e-10   2.3e-07      74     164 ..     196     299 ..     119     300 .. 0.76

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 1.4e-10
  Methyltransf_23  74 qeaaepqgkfdlIvlrevlehvpd..ppellrqiatllkpgGylllseplaslkedrllld...........wlylvpagrhisffsarslkel 154
                      q  + p+++ dlI+++ +l+h  d  +  +++ ++++l+p+G ++l+e++++ ++ +++ +            ++++++ + ++f s ++++ +
       EFC39575.1 196 QLHDIPSNSVDLITCFIGLHHYTDteLNLYMKELKRILRPNGIFILREHDVDNEHMESMVHvahnifnaltgLTFEDNEKEFRHFRSMKEWNSI 289
                      22344889***************966779********************9998555555554566666666677889999************** PP

  Methyltransf_23 155 leeaGlevve 164
                      ++ +G+ ++e
       EFC39575.1 290 CKSFGFYNLE 299
                      ******8875 PP

>> Methyltransf_29  Putative S-adenosyl-L-methionine-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.4   0.0   7.5e-10   1.2e-06     159     253 ..     180     277 ..     126     298 .. 0.78

  Alignments for each domain:
  == domain 1  score: 27.4 bits;  conditional E-value: 7.5e-10
  Methyltransf_29 159 LeRgvpailavlg.tkrl.pyPsrsfdlihCsrCridwteed.gilllevdRvlRpgGyfvlsappvyerkeeelkeeqkeleeltkslCwklv 249
                      LeR+  + ++ +    +l   Ps+s dli C   + ++t+++  +++ e++R+lRp+G f+l  ++v ++++e   +  +++ + ++ l ++  
       EFC39575.1 180 LERKSLTPVGKFVpYDQLhDIPSNSVDLITCFIGLHHYTDTElNLYMKELKRILRPNGIFILREHDVDNEHMESMVHVAHNIFNALTGLTFEDN 273
                      666555555544313344257*****************988746899************************99999999999999999988877 PP

  Methyltransf_29 250 akkk 253
                      +k+ 
       EFC39575.1 274 EKEF 277
                      7665 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   4.2e-08   6.8e-05      46      97 .]     187     237 ..     148     237 .. 0.67
   2 ?   -2.5   0.0       5.3   8.6e+03      80      97 .]     391     408 ..     384     408 .. 0.79

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 4.2e-08
                      TTEEEEESBC.CGBSSSTTTEEEEEEESTGGGSSHHHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  46 lnvefvqgda.edlpfedgsfDlvvssgalhhlsdedlekalkeiarvLkpgG 97 
                      +  +fv  d  +d+  +++s+Dl++++ +lhh++d +l  ++ke++r+L+p+G
       EFC39575.1 187 PVGKFVPYDQlHDI--PSNSVDLITCFIGLHHYTDTELNLYMKELKRILRPNG 237
                      45566665542334..689*******988**********************99 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 5.3
                      HHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  80 edlekalkeiarvLkpgG 97 
                      + ++ +++ + rv+k +G
       EFC39575.1 391 KFWKLFFNSCTRVMKRDG 408
                      45778999*******998 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.8   6.2e+03      63      76 ..     127     142 ..      99     182 .. 0.68
   2 !   20.8   0.0   1.6e-07   0.00026      66     128 ..     200     260 ..     167     291 .. 0.76
   3 ?   -2.9   0.0       3.2   5.3e+03      55      86 ..     454     486 ..     445     497 .. 0.59

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.8
  Methyltransf_31  63 iee.lekl.ledekfD 76 
                      i e le++ l+ +kfD
       EFC39575.1 127 ISElLESNiLHNRKFD 142
                      4444444444445554 PP

  == domain 2  score: 20.8 bits;  conditional E-value: 1.6e-07
  Methyltransf_31  66 leklledekfDlilsnevl..naladpdkileeiervlkpggilliedprllaelpakveeeska 128
                      ++     +++Dli+++  l  ++ ++++ +++e++r l+p+gi++++++++  e  +++ +  ++
       EFC39575.1 200 IP----SNSVDLITCFIGLhhYTDTELNLYMKELKRILRPNGIFILREHDVDNEHMESMVHVAHN 260
                      44....389*******8885566667789999******************766666666666553 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 3.2
  Methyltransf_31  55 nveFeqgdieelekl.ledekfDlilsnevlna 86 
                      n++  q+ i ++e    + ek D+ + ne++n+
       EFC39575.1 454 NITTIQAIISAKEDIrSTLEKCDIHIINETMND 486
                      444444444444433333478888888877754 PP

>> DIOX_N  non-haem dioxygenase in morphine synthesis N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   0.0   1.7e-05     0.028      18      56 ..     225     263 ..     211     267 .. 0.88
   2 ?   -1.2   0.0       2.1   3.4e+03      23      41 ..     287     305 ..     268     318 .. 0.79
   3 ?   -0.7   0.0       1.4   2.3e+03      16      38 ..     574     596 ..     569     597 .] 0.87

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1.7e-05
      DIOX_N  18 vaeqlreAcrevGffyvvnhgvpeelidelfeaareFFa 56 
                  +++l++ +r  G+f++ +h+v++e ++ + ++a++ F+
  EFC39575.1 225 YMKELKRILRPNGIFILREHDVDNEHMESMVHVAHNIFN 263
                 6799********************************996 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 2.1
      DIOX_N  23 reAcrevGffyvvnhgvpe 41 
                  + c+++Gf  ++n ++++
  EFC39575.1 287 NSICKSFGFYNLENYQLQH 305
                 6789******999988764 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 1.4
      DIOX_N  16 aavaeqlreAcrevGffyvvnhg 38 
                 +++++ lreA+ ++G+ ++  h+
  EFC39575.1 574 KNLIQFLREAMNQTGLEQIQIHD 596
                 578899**********9999986 PP

>> TFIID_NTD2  WD40 associated region in TFIID subunit, NTD2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.2   0.00019       0.3       8     119 ..     208     322 ..     202     337 .. 0.80
   2 !    6.7   0.5    0.0048       7.9      69     121 ..     535     587 ..     501     595 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00019
                 HHHHHHHHHHHHTS-HHHHHHHGGGHHH..HHHHHHHHHHHTT-HHH....HHHHHHHHGGGGGGGHH.HHHHHTT--SHHHHHHSHHHHHHHHS-EEE CS
  TFIID_NTD2   8 ekayelLkkwiessldiykpeLsrllyP..vFvhlyLelvakgaeee....akkFfekfkedhealhkedlkkLasisspehleenelakafrenkyri 100
                  + +  L+++ ++ l++y +eL+r+l P  +F+    + v ++++e+    a++ f+++ +   +  +++ ++++s+++ + + ++    ++  ++y++
  EFC39575.1 208 ITCFIGLHHYTDTELNLYMKELKRILRPngIFILREHD-VDNEHMESmvhvAHNIFNALTGLTFEDNEKEFRHFRSMKEWNSICKSFGFYNL--ENYQL 303
                 567999**********************5556655555.55555555588889999999997666777789999999999998887777666..99*** PP

                 EEEHHHHHHHHHHHHHTT- CS
  TFIID_NTD2 101 klskaafelLlrfLeekek 119
                 +  +++++l++ +++ek+ 
  EFC39575.1 304 QHGDSTIDLMTAYVNEKDG 322
                 *************999875 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0048
                 H.HHHHHTT--SHHHHHHSHHHHHHHHS-EEEEEEHHHHHHHHHHHHHTT-HH CS
  TFIID_NTD2  69 kedlkkLasisspehleenelakafrenkyriklskaafelLlrfLeekekav 121
                 + ++ k++s+ + +++e+ +++ + ++++ ++ + + ++++L++fL+e  +++
  EFC39575.1 535 NPNIIKFSSLVKCQEIENYQVVPNNEHHNETVIIYSVSVKNLIQFLREAMNQT 587
                 5578999****************************************988874 PP

>> Methyltransf_PK  AdoMet dependent proline di-methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.7   0.0     1e-05     0.017     113     167 ..     188     249 ..     128     261 .. 0.81
   2 ?   -2.5   0.0       1.8     3e+03     180     213 ..     463     495 ..     456     496 .. 0.75

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1e-05
  Methyltransf_PK 113 lqeftPe.......egrYdliWiqWcvghLtDedlvaflkrckkalkpnGlivvkenvakee 167
                      + +f+P        +++ dli +   + h tD +l  ++k  k+ l+pnG+++++e    +e
       EFC39575.1 188 VGKFVPYdqlhdipSNSVDLITCFIGLHHYTDTELNLYMKELKRILRPNGIFILREHDVDNE 249
                      45555544444555788999999999*****************************9866655 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.8
  Methyltransf_PK 180 rseaklkklfkkagLklvaeelqkglPkelypvk 213
                       +++ +++ ++k+++++++e++  +  + ly+vk
       EFC39575.1 463 SAKEDIRSTLEKCDIHIINETMN-DKREYLYHVK 495
                      56788999999***999988765.4456677776 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.0     2e-05     0.033      64      99 .]     185     239 ..     151     239 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 2e-05
  Methyltransf_12  64 g.................ssfDlvvas.nvlhhl.kdirevldnirklLkpgGrl 99 
                                        +s+Dl++++ ++ h++  +++ +++++++ L+p+G++
       EFC39575.1 185 LtpvgkfvpydqlhdipsNSVDLITCFiGLHHYTdTELNLYMKELKRILRPNGIF 239
                      3455555555555556669********555555588899**************85 PP

>> PRELI  PRELI-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.8   2.4e-05      0.04      38     136 ..     487     592 ..     474     595 .. 0.72

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.4e-05
                 EEEEEEEEESSTTS......TTTSSSEEEEEEEEEEEEETTTTEEEEEEEE.SSSTTTEEEEEEEEEEEETTTT....EEEEEEEEEE..HHHHHHHHH CS
       PRELI  38 eRlitlqvrvPrwl......kkligvaktvyvleesvvdlkkrtlkletrN.ltfssllkveErvvYkphpens..ekTvlkqeakisvkgslfglssk 127
                 +R    +v++Pr+l      ++l++ + +++++e      ++ +++++  N ++fssl+k++E   Y++ p+n+  + Tv+  ++++  k+ +  l ++
  EFC39575.1 487 KREYLYHVKLPRFLpftqslQHLAKQTPYAQLEEIAGNQMVNVKITIRNPNiIKFSSLVKCQEIENYQVVPNNEhhNETVIIYSVSV--KNLIQFLREA 583
                 555566666666642221114466766667777777777778888888888459*******************95556666666666..5567899999 PP

                 HHHHHHHHH CS
       PRELI 128 veklllkkf 136
                 +++++l+++
  EFC39575.1 584 MNQTGLEQI 592
                 999999987 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   3.2e-05     0.052      65     217 ..     153     299 ..     133     313 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.2e-05
                      HHHHHHHHHEEEEEES-HHHHHHHHHHHHHHTSSTEEEEE--TTT-TTS-T-EEEEEEES-GGG-S-HHHHH..HHHHHHEEEEEEEEEEEE-- CS
  Ubie_methyltran  65 lsdsvgekgkvvvlDinenmLkvgekklkeegkinieflqanaeeLpfeddsfDvvtvsfGlrnvtDklkaL..keayrvlkpGGrlvvlefsk 156
                      +++ +++k+kv +  +  n  + + + l++++ + +   +   +  +   +s D++t   Gl   tD++  L  ke+ r+l+p G+++  e   
       EFC39575.1 153 FTNLLKKKFKVSGSSFVVNDKERATDVLERKSLTPVGKFVPYDQLHDIPSNSVDLITCFIGLHHYTDTELNLymKELKRILRPNGIFILRE-HD 245
                      56667777777777777777777777777777777766666666667788*****************98765449**********987666.46 PP

                      --SHHHHHHHHHHHH.HHHHHHHHHHS-HHHHHHHHHHHHHS--HHHHHHHHHHTTEEEEE CS
  Ubie_methyltran 157 velpllsqayelyskevlPvlGkllakdldsyryLvesirafPdqetlkeliedaGfksve 217
                      v ++ ++   ++    +    G  + ++ +++r       +f  +++ +++ +  Gf + e
       EFC39575.1 246 VDNEHMESMVHVAHNIFNALTGLTFEDNEKEFR-------HFRSMKEWNSICKSFGFYNLE 299
                      777777666555544444566666766666654.......455555666666666665555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (597 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       794  (0.0442858); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.69u 0.34s 00:00:01.03 Elapsed: 00:00:00.53
# Mc/sec: 3384.62
//
Query:       EFC39576.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-23   82.3   0.3    4.7e-23   81.6   0.3    1.3  1  SAS-6_N   Centriolar protein SAS N-terminal


Domain annotation for each model (and alignments):
>> SAS-6_N  Centriolar protein SAS N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.6   0.3   2.6e-27   4.7e-23       1      83 [.     109     189 ..     109     191 .. 0.97

  Alignments for each domain:
  == domain 1  score: 81.6 bits;  conditional E-value: 2.6e-27
                 EEEEEEETTEEEEEEEEEEEHHHHHHHHHHCTB-S-CCCHHHHHHHHHHHHHHS...SSEEEECCTTTSSEEEEEEEEE-SSB CS
     SAS-6_N   1 lrieltdenDlfflytleiseedFeelkeeqnLlvdFaeFpsklikllnscqkpekkkylavlslekdegqakLsivetneFk 83 
                 +++elt+e+Dlff+y++++ +++F  l+++q+L+vdF ++p+ l k+ln c k e++++l++l +e+d+ ++ L++v+++e+k
  EFC39576.1 109 VKLELTSESDLFFHYSHTVGRQQFIGLQQSQKLMVDFPNYPKMLSKMLNACVK-EPESFLCILIMERDG-KGLLNFVQNMEYK 189
                 689************************************************88.799******999999.************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       390  (0.0217525); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.32s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 1118.04
//
Query:       EFC39577.1  [L=409]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1490  (0.0831056); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.52
# Mc/sec: 2345.55
//
Query:       EFC39578.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.6e-17   60.3  46.3      0.016   15.2   0.3   10.5 10  LRR_6     Leucine Rich repeat
    1.5e-15   56.7  57.0    4.2e-07   29.6  11.6    5.3  5  LRR_8     Leucine rich repeat
    4.7e-13   49.1  62.0    0.00012   22.4   6.5    6.8  8  LRR_4     Leucine Rich repeats (2 copies)
    0.00026   20.5   8.4     0.0023   17.5   5.8    2.7  2  LRR_9     Leucine-rich repeat
  ------ inclusion threshold ------
      0.013   16.0  47.7        1.1   10.1   1.0   10.3  9  LRR_1     Leucine Rich Repeat
       0.04   14.1   4.6        5.6    7.3   0.6    3.6  3  YjcQ      YjcQ protein


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.8   0.0    0.0028       8.3       6      23 ..       2      19 ..       1      20 [. 0.89
   2 !   15.2   0.3   5.2e-06     0.016       4      20 ..      24      40 ..      22      44 .. 0.89
   3 !   13.9   0.2   1.4e-05     0.043       4      22 ..      48      66 ..      45      68 .. 0.88
   4 !    8.4   0.8    0.0008       2.4       2      20 ..      70      88 ..      69      92 .. 0.88
   5 !   14.6   0.3   8.3e-06     0.025       1      23 [.      93     115 ..      93     116 .. 0.92
   6 ?    2.9   1.6     0.049   1.5e+02       3      15 ..     119     131 ..     117     132 .. 0.85
   7 !    9.8   0.3   0.00029      0.85       3      17 ..     142     156 ..     140     157 .. 0.87
   8 ?    4.6   0.1     0.014        42       4      18 ..     168     183 ..     167     189 .. 0.80
   9 !    6.3   0.1    0.0039        12       3      24 .]     192     214 ..     190     214 .. 0.90
  10 !    5.9   0.1     0.005        15      11      23 ..     224     236 ..     215     237 .. 0.75

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0028
       LRR_6  6 teLdLsgNdIgDeGaeaL 23
                ++L+Ls  +I+ +G++ +
  EFC39578.1  2 ESLNLSNSEITSSGISQF 19
                89************9976 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 5.2e-06
       LRR_6  4 hLteLdLsgNdIgDeGa 20
                +L+eLdLs+N I+ eGa
  EFC39578.1 24 NLQELDLSSNLINSEGA 40
                8***************9 PP

  == domain 3  score: 13.9 bits;  conditional E-value: 1.4e-05
       LRR_6  4 hLteLdLsgNdIgDeGaea 22
                +Lt+L L++N I++eG+  
  EFC39578.1 48 NLTSLALNDNSITGEGLRN 66
                8***************976 PP

  == domain 4  score: 8.4 bits;  conditional E-value: 0.0008
       LRR_6  2 nthLteLdLsgNdIgDeGa 20
                 t+LteL L  N+Ig +Ga
  EFC39578.1 70 LTNLTELFLDNNNIGSVGA 88
                689***************8 PP

  == domain 5  score: 14.6 bits;  conditional E-value: 8.3e-06
       LRR_6   1 snthLteLdLsgNdIgDeGaeaL 23 
                 snt+++ L Ls N I DeG+e +
  EFC39578.1  93 SNTNIKFLTLSNNSIADEGLENF 115
                 69******************965 PP

  == domain 6  score: 2.9 bits;  conditional E-value: 0.049
       LRR_6   3 thLteLdLsgNdI 15 
                  +L +L+L++N++
  EFC39578.1 119 KSLIHLNLNFNNV 131
                 5799*******97 PP

  == domain 7  score: 9.8 bits;  conditional E-value: 0.00029
       LRR_6   3 thLteLdLsgNdIgD 17 
                   L+ Ld+++N+++D
  EFC39578.1 142 KLLKQLDIQHNNLTD 156
                 569***********9 PP

  == domain 8  score: 4.6 bits;  conditional E-value: 0.014
       LRR_6   4 hLteLdLsgNd.IgDe 18 
                 +++eLdLs N+ ++++
  EFC39578.1 168 SIEELDLSENKkLSGK 183
                 679*******988765 PP

  == domain 9  score: 6.3 bits;  conditional E-value: 0.0039
       LRR_6   3 thLteLdLsgNd.IgDeGaeaLa 24 
                 ++L  L++ +N  +gD  ++ La
  EFC39578.1 192 RKLSILNIGSNPkLGDLSLSHLA 214
                 68999***********9999987 PP

  == domain 10  score: 5.9 bits;  conditional E-value: 0.005
       LRR_6  11 sgNdIgDeGaeaL 23 
                 + ++I+D+G+ ++
  EFC39578.1 224 NNCGITDKGLVKF 236
                 5677******986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   9.3   3.7e-10   1.1e-06       4      61 .]       2      59 ..       1      59 [. 0.97
   2 !   29.6  11.6   1.4e-10   4.2e-07       2      61 .]      48     107 ..      47     107 .. 0.98
   3 !   13.3   7.6   1.8e-05     0.053      19      61 .]     113     154 ..     111     154 .. 0.92
   4 !    9.8   2.2   0.00021      0.63       3      45 ..     144     185 ..     142     190 .. 0.75
   5 !    8.5   8.8   0.00056       1.7       4      60 ..     170     225 ..     168     225 .. 0.80

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 3.7e-10
                SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  4 tsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61
                +sL+Lsn+ +ts + ++F  l+nL++LdLs+Nl+++  ++ +s+L +L+sL L++N +
  EFC39578.1  2 ESLNLSNSEITSSGISQFGILKNLQELDLSSNLINSEGANYLSSLYNLTSLALNDNSI 59
                69******************************************************86 PP

  == domain 2  score: 29.6 bits;  conditional E-value: 1.4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLtsL L++N++t+ +   F++l+nL++L L nN++ ++ ++ +s+ +++++L+Ls+N +
  EFC39578.1  48 NLTSLALNDNSITGEGLRNFSNLTNLTELFLDNNNIGSVGANYLSSNTNIKFLTLSNNSI 107
                 8*********************************************************87 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 1.8e-05
                 TSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8  19 eaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 e F +l++L +L+L+ N+ ++ l    +s ++ L++Ld+++N+L
  EFC39578.1 113 ENFGNLKSLIHLNLNFNNVQRgL--IYLSECKLLKQLDIQHNNL 154
                 579**************999954..69***************98 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00021
                 -SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGG CS
       LRR_8   3 LtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgaf 45 
                 L+ Ld+++N+lt+ +   F++   + ++LdLs+N  + ls ++f
  EFC39578.1 144 LKQLDIQHNNLTDQELIDFFDkELSIEELDLSEN--KKLSGKSF 185
                 8899999999999887655555889999999999..44444555 PP

  == domain 5  score: 8.5 bits;  conditional E-value: 0.00056
                 SEEE-TTS--SEE-TTSSTT...-TT--EEE--SS.---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   4 tsLdLsnNrltslddeaFkg...lsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsgNr 60 
                 ++LdLs N+  +l+ ++Fk+    ++L +L++++N +l  l   ++s+L+sL  L+L+ N+
  EFC39578.1 170 EELDLSENK--KLSGKSFKNickQRKLSILNIGSNpKLGDL---SLSHLASLNLLTLRANN 225
                 678888886..455555555433789***************...6*************996 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   6.9   2.8e-06    0.0084       4      42 ..       2      49 ..       1      50 [. 0.80
   2 !   22.4   6.5   3.9e-08   0.00012       2      39 ..      48      86 ..      47      93 .. 0.88
   3 !   18.1   7.0   9.1e-07    0.0027       1      34 [.      95     130 ..      95     135 .. 0.90
   4 !   16.2   6.4   3.5e-06     0.011       1      36 [.     119     155 ..     119     164 .. 0.84
   5 !   11.6   3.3   9.7e-05      0.29       3      36 ..     144     180 ..     142     187 .. 0.81
   6 !   11.6   3.1   9.9e-05       0.3       3      42 ..     169     210 ..     167     215 .. 0.77
   7 ?    1.7   0.2      0.13   3.9e+02       2      15 ..     217     230 ..     216     239 .. 0.87
   8 ?   -1.8   0.1       1.6   4.9e+03      22      37 ..     260     274 ..     248     279 .. 0.63

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 2.8e-06
                -EEE--SS---E-S-HH.H.-TT--EEE-.-S.......-----GGGG CS
       LRR_4  4 evLdLsnNqltdiplle.k.lpnLkeLdLsgN.......nlitdldeL 42
                e+L+Lsn  +t+ +  + + l+nL+eLdLs+N       n++++l++L
  EFC39578.1  2 ESLNLSNSEITSSGISQfGiLKNLQELDLSSNlinsegaNYLSSLYNL 49
                78****99***988855666*********9997777777777776665 PP

  == domain 2  score: 22.4 bits;  conditional E-value: 3.9e-08
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39
                nL++L L++N +t  +l  +++l+nL+eL L +Nn+i+++
  EFC39578.1 48 NLTSLALNDNSITGEGLrnFSNLTNLTELFL-DNNNIGSV 86
                9************988866669*********.88899887 PP

  == domain 3  score: 18.1 bits;  conditional E-value: 9.1e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNn 34 
                 +n ++L LsnN + d +l  +++l++L +L+L++Nn
  EFC39578.1  95 TNIKFLTLSNNSIADEGLenFGNLKSLIHLNLNFNN 130
                 799************99977779*********8885 PP

  == domain 4  score: 16.2 bits;  conditional E-value: 3.5e-06
                 SS--EEE--SS---.E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqlt.diplleklpnLkeLdLsgNnli 36 
                 ++L++L+L+ N+++  +  l+ ++ Lk+Ld+ +Nnl 
  EFC39578.1 119 KSLIHLNLNFNNVQrGLIYLSECKLLKQLDIQHNNLT 155
                 68************77666778*********888543 PP

  == domain 5  score: 11.6 bits;  conditional E-value: 9.7e-05
                 --EEE--SS---E-S-HHH-TT...--EEE-.-S--- CS
       LRR_4   3 LevLdLsnNqltdiplleklpn...LkeLdLsgNnli 36 
                 L+ Ld+++N+ltd +l+  +++    +eLdLs+N ++
  EFC39578.1 144 LKQLDIQHNNLTDQELIDFFDKelsIEELDLSENKKL 180
                 899**********999664555556*********665 PP

  == domain 6  score: 11.6 bits;  conditional E-value: 9.9e-05
                 --EEE--.SS---E-S-HH...H-TT--EEE-.-S-----GGGG CS
       LRR_4   3 LevLdLs.nNqltdiplle...klpnLkeLdLsgNnlitdldeL 42 
                  e+LdLs n +l+   +++   k  +L  L++ +N++++dl+ L
  EFC39578.1 169 IEELDLSeNKKLSGK-SFKnicKQRKLSILNIGSNPKLGDLS-L 210
                 689****6669**54.4552445666******99******95.5 PP

  == domain 7  score: 1.7 bits;  conditional E-value: 0.13
                 S--EEE--SS---E CS
       LRR_4   2 nLevLdLsnNqltd 15 
                 nL +L  +n+ +td
  EFC39578.1 217 NLLTLRANNCGITD 230
                 89999*******98 PP

  == domain 8  score: -1.8 bits;  conditional E-value: 1.6
                 -TT--EEE-.-S---- CS
       LRR_4  22 lpnLkeLdLsgNnlit 37 
                 +  L+eL L++ ++i+
  EFC39578.1 260 NIALEEL-LNQASFIE 274
                 4458888.75555555 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   0.1   0.00019      0.55      46     101 ..       3      60 ..       1      64 [. 0.80
   2 !   17.5   5.8   7.6e-07    0.0023      23     127 ..      27     133 ..      24     159 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00019
       LRR_9  46 tidlsdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelq 101
                 +++ls+ +i    + +f  lk l+ l l++n i   + +   +l nl++l l++n+++
  EFC39578.1   3 SLNLSNSEITSsgISQFGILKNLQELDLSSNLINSEGANYLSSLYNLTSLALNDNSIT 60 
                 5677888886433788999999999999999999999999999999999999999875 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 7.6e-07
       LRR_9  23 eldlrgykipv.ienlGatldqfdtidlsdndir..kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklell 118
                 eldl ++ i     n  ++l  + ++ l+dn i    l +f  l  l  l+l+nn i  ++ +   +  n++ l l+nn++ + + l+ + +lk+l  l
  EFC39578.1  27 ELDLSSNLINSeGANYLSSLYNLTSLALNDNSITgeGLRNFSNLTNLTELFLDNNNIGSVGANYLSSNTNIKFLTLSNNSIADEG-LENFGNLKSLIHL 124
                 666666665431456667888889999******63369*******************************************9854.6889999999998 PP

       LRR_9 119 sllknpvtn 127
                  l  n v +
  EFC39578.1 125 NLNFNNVQR 133
                 888877765 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0      0.17     5e+02       3      16 ..       2      15 ..       1      21 [. 0.75
   2 ?   10.1   1.0   0.00036       1.1       1      23 []      24      46 ..      24      46 .. 0.92
   3 ?    6.7   0.6    0.0046        14       1      23 []      48      70 ..      48      70 .. 0.96
   4 ?    6.0   0.4    0.0078        23       1      21 [.      72      92 ..      72      94 .. 0.90
   5 ?    4.4   0.3     0.027        80       1      23 []      96     118 ..      96     118 .. 0.83
   6 ?    4.0   0.5     0.036   1.1e+02       1      12 [.     120     131 ..     120     142 .. 0.81
   7 ?    4.9   0.1     0.019        56       2      14 ..     144     157 ..     143     166 .. 0.75
   8 ?    2.0   0.1      0.16   4.9e+02       2      19 ..     169     184 ..     168     190 .. 0.68
   9 ?    2.5   2.8      0.12   3.5e+02       1      20 [.     193     213 ..     193     236 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.17
       LRR_1  3 rhLdLsnnpllglp 16
                ++L+Lsn  +++ +
  EFC39578.1  2 ESLNLSNSEITSSG 15
                79*****9986544 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00036
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                nL++LdLs+n + + ++n++++L
  EFC39578.1 24 NLQELDLSSNLINSEGANYLSSL 46
                8***********99999999876 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0046
       LRR_1  1 nLrhLdLsnnpllglppnsfqnL 23
                nL++L L++n+++g + + f+nL
  EFC39578.1 48 NLTSLALNDNSITGEGLRNFSNL 70
                8*******************997 PP

  == domain 4  score: 6.0 bits;  conditional E-value: 0.0078
       LRR_1  1 nLrhLdLsnnpllglppnsfq 21
                nL++L L nn++++ ++n+++
  EFC39578.1 72 NLTELFLDNNNIGSVGANYLS 92
                8***********999999887 PP

  == domain 5  score: 4.4 bits;  conditional E-value: 0.027
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 n + L Lsnn++ + + + f nL
  EFC39578.1  96 NIKFLTLSNNSIADEGLENFGNL 118
                 7899********88888877776 PP

  == domain 6  score: 4.0 bits;  conditional E-value: 0.036
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L hL+L+ n+ 
  EFC39578.1 120 SLIHLNLNFNNV 131
                 699*******85 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.019
       LRR_1   2 LrhLdLsnnpl.lg 14 
                 L+ Ld+ +n+l ++
  EFC39578.1 144 LKQLDIQHNNLtDQ 157
                 899*******9544 PP

  == domain 8  score: 2.0 bits;  conditional E-value: 0.16
       LRR_1   2 LrhLdLsnnpllglppns 19 
                  ++LdLs n    l+  s
  EFC39578.1 169 IEELDLSENK--KLSGKS 184
                 699***9998..344444 PP

  == domain 9  score: 2.5 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnp.llglppnsf 20 
                 +L  L++++np l++l+ +++
  EFC39578.1 193 KLSILNIGSNPkLGDLSLSHL 213
                 6889*******3344444444 PP

>> YjcQ  YjcQ protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.54   1.6e+03      62      78 ..      28      44 ..       4      49 .. 0.66
   2 ?    7.3   0.6    0.0019       5.6      34      84 ..      47      98 ..      19     102 .. 0.70
   3 ?    6.6   0.1     0.003       8.9      58      82 ..     217     242 ..     142     252 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.54
                --SS--EE-HHHHHHHH CS
        YjcQ 62 isidnvritlkGleyLk 78
                + +++  i ++G +yL+
  EFC39578.1 28 LDLSSNLINSEGANYLS 44
                44555667777777776 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0019
                HHHHHHHHHHHTSEE--EESSS.....SEE--SS--EE-HHHHHHHHHHT-S- CS
        YjcQ 34 fndiiemlveegyikGvkvkktkk..geivisidnvritlkGleyLkeNsmmk 84
                +n +   l + + i+G  +++  +  +   +++dn +i + G +yL++N+ +k
  EFC39578.1 47 YNLTSLALND-NSITGEGLRNFSNltNLTELFLDNNNIGSVGANYLSSNTNIK 98
                5555555544.456555555544443788999*****************9765 PP

  == domain 3  score: 6.6 bits;  conditional E-value: 0.003
                 .SEE--SS--EE-HHHH.HHHHHHT- CS
        YjcQ  58 geivisidnvritlkGl.eyLkeNsm 82 
                 +  ++  +n  it kGl ++L+eNs 
  EFC39578.1 217 NLLTLRANNCGITDKGLvKFLQENSN 242
                 5566778999******659*****96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       680  (0.0379274); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.61u 0.34s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1818.14
//
Query:       EFC39579.1  [L=414]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.41   10.6   0.0       0.41   10.6   0.0    3.0  3  PX        PX domain
        4.9    7.1  36.7        6.7    6.6  36.7    1.2  1  TFIIA     Transcription factor IIA, alpha/beta subunit


Domain annotation for each model (and alignments):
>> PX  PX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   4.6e-05      0.41      73     112 ..      40      79 ..      11      80 .. 0.85
   2 ?   -2.4   5.1       0.5   4.5e+03      54      73 ..     137     184 ..     111     262 .. 0.72
   3 ?   -2.9   0.0      0.75   6.7e+03      60      71 ..     294     304 ..     281     325 .. 0.53

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 4.6e-05
                 CTTSHHHHHHHHHHHHHHHHHHHTSCHHHHSHHHHHHHHS CS
          PX  73 rkkdeefiekrrkgLeeyLqrllnhpelrnsevlteFLev 112
                 + +d +++e+rr ++e  L++++ h +++  + +++F ev
  EFC39579.1  40 EEFDYDIVEERRLSFEIILREMADHHQIVIAPLFRRFVEV 79 
                 68999********************************886 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.5
                 HHTTSTSTSSSTSGSSSSS............................C CS
          PX  54 kfprvkiPplPkkvlfgsv............................r 73 
                 + ++v+iPp P+ +++++                             +
  EFC39579.1 137 QQVTVIIPPPPQQQTVKTAspqppveavspvspqqpqtsipvrtqqeQ 184
                 334899999999999987566666666666655555555555555550 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 0.75
                 STSSSTSGSSSS CS
          PX  60 iPplPkkvlfgs 71 
                 + plP+k+  ++
  EFC39579.1 294 V-PLPPKRKSQE 304
                 4.4444443332 PP

>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.6  36.7   0.00074       6.7      45     288 ..      85     328 ..      79     409 .. 0.42

  Alignments for each domain:
  == domain 1  score: 6.6 bits;  conditional E-value: 0.00074
       TFIIA  45 efpwdpkpeeaqspqfvlqlpqslkqalqasaaaa........sqapastsqslpslvipagksvqsltanssaataatfslpakleppvqipagvtlq 135
                  fp d++ ++ ++  + +  p  + + ++ s++a         s+ ++  s+++ +++ip + + q +++ s +   ++ s+ + ++p+  ip+ ++++
  EFC39579.1  85 VFPSDFNINSYTARRKSTVTPRDQPKHQSISKKAPpppppssqSSVNQLDSEQQVTVIIPPPPQQQTVKTASPQPPVEAVSPVSPQQPQTSIPVRTQQE 183
                 566666555544444433333322222221111112333333233333344444444555553333333233335556666666666666666655555 PP

       TFIIA 136 tasgqlykvnvqasgaqqiaaqplqqvvqqsqgsaaqssvaalqaqsqqaqalaepqqqlekqqqqqqqqqqqqqqq.qvqqqqqeesqqaqqasqeqv 233
                 ++s+    + v+ ++++q+ +qp+ +vv  +++ ++ s ++a q+q    q+ +++qqq++    ++ +qqq+   +  +++  + ++q++q+ + + +
  EFC39579.1 184 QPSPV---SPVKRNSQSQLEQQPVPEVVDPNTPVIILSPTTAQQSQ----QQFSQQQQQAQ---PTVPHQQQPVDVStFIEEMRM-QHQNRQSLKSNPT 271
                 55532...22377777777788888886665555554444443322....22223233311...111111122221212222221.1111111111111 PP

       TFIIA 234 ag.sqvessqtdgaedaleeespv..legelsaeeeagaqkeelsreeidri.reealk 288
                 ++  qv+ + ++  ed  e ++ v     ++s+e+++   + e s+++++r+ +ee+++
  EFC39579.1 272 SPvVQVSEPVKELDEDVIEVRQ-VplPPKRKSQERTSSP-QYENSKTDARRFtEEESTD 328
                 1213333333333333333211.1223333333333332.2333334444443222111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (414 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1570  (0.0875676); expected 358.6 (0.02)
Passed bias filter:                      468  (0.026103); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 2417.07
//
Query:       EFC39580.1  [L=153]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.2e-20   71.5   0.0      1e-19   71.2   0.0    1.0  1  Polyketide_cyc2  Polyketide cyclase / dehydrase and lipid tra
      0.001   19.3   0.1     0.0013   19.0   0.1    1.4  1  Polyketide_cyc   Polyketide cyclase / dehydrase and lipid tra


Domain annotation for each model (and alignments):
>> Polyketide_cyc2  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   71.2   0.0   1.1e-23     1e-19       1     141 [.       3     151 ..       3     152 .. 0.85

  Alignments for each domain:
  == domain 1  score: 71.2 bits;  conditional E-value: 1.1e-23
                      EEEEEEEEEESS-HHHHHHHHTTTTGGGGT-TTEEEEECSESTSSSTTTEEEEECCCS........SEEEEEEEEEETTTTEEEEEEE..SSS- CS
  Polyketide_cyc2   1 mvkvtvsvviaappekVwalvsdfenwprWhpevarveleggggpargvegtvrvggr........gtvreelvevdpegrllsyriv.kpvpv 85 
                      +vkv +s+vi+a++e+Vw +v +f+++p+W   v+++ legg ++   + g+vrv+++        +++re+l+++d ++++++y+i  +p+p+
       EFC39580.1   3 QVKVYRSAVINASVETVWQVVKNFNELPKWTGVVSDSVLEGGMQD--NSIGCVRVVSLlnpnpqddRPIREQLIAYDSRNHSFTYKILsGPKPF 94 
                      5899*********************************99986666..667****99999999999888*********99********7767776 PP

                      T...SEEEEEEEEECCET..EEEEEEEEEEEE--TT--HHHHHHHHHHHHHHHHHHHHHHH CS
  Polyketide_cyc2  86 a...nyvatwtvtpdggg..trvtwtgefdagplggpfekpaaakavkgdleagLerLkar 141
                      +    y at+t+    +   t ++w+ ef +      ++ + ++k+ ++ + +g++ L+++
       EFC39580.1  95 EyfnEYYATVTLVKITDSnqTFIEWKSEFTC----PQGNQEQFEKFAGAVYMKGIKSLQQQ 151
                      5333777888888866655588********8....55566778999999999999999875 PP

>> Polyketide_cyc  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.1   1.4e-07    0.0013       1      35 [.      12      45 ..      12     134 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 1.4e-07
                    ESS-HHHHHHHHTTTGGCCSCCCCEEEEEE.SSSE CS
  Polyketide_cyc  1 vpapadqvyalvadvesypeflphcssvevleeae 35
                    ++a++++v+++v +++ +p+++  +s+++ le   
      EFC39580.1 12 INASVETVWQVVKNFNELPKWTGVVSDSV-LEGGM 45
                    79********************9888654.33333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (153 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       521  (0.0290591); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 1018.66
//
Query:       EFC39581.1  [L=144]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0046   17.4   1.4     0.0066   16.9   1.4    1.2  1  LPAM_1          Prokaryotic membrane lipoprotein lipid attach
  ------ inclusion threshold ------
       0.03   14.7   5.3       0.03   14.7   5.3    3.3  2  Mfp-3           Foot protein 3


Domain annotation for each model (and alignments):
>> LPAM_1  Prokaryotic membrane lipoprotein lipid attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   1.4   7.4e-07    0.0066       1      17 [.       1      17 [.       1      17 [. 0.99

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 7.4e-07
      LPAM_1  1 MKKillalgalllLsGC 17
                M K++ al+a+llL++C
  EFC39581.1  1 MNKFIAALVATLLLASC 17
                9**************** PP

>> Mfp-3  Foot protein 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   5.3   3.3e-06      0.03       3      53 ..       2      58 ..       1      63 [. 0.76
   2 ?  -28.4  44.4         2   1.8e+04      28      35 ..      99     106 ..      59     142 .. 0.52

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 3.3e-06
       Mfp-3  3 nssvsvlvvlvliGsfavesdaadyyGpnyGpp....rryG..Ggyynrynryarry 53
                n  ++ lv+ +l+ s  v+ + ++ yG nyG        yG  Gg yn+y + ++ y
  EFC39581.1  2 NKFIAALVATLLLASCLVNCQYSNNYGTNYGTSggsgSNYGvtGGNYNQYGQNTQSY 58
                556889************************976222256665567777777666655 PP

  == domain 2  score: -28.4 bits;  conditional E-value: 2
       Mfp-3  28 yGpnyGpp 35 
                 yG  yG p
  EFC39581.1  99 YGGGYGIP 106
                 34444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (144 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       506  (0.0282224); expected 358.6 (0.02)
Passed bias filter:                      243  (0.0135535); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.46
# Mc/sec: 934.07
//
Query:       EFC39582.1  [L=243]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       914  (0.0509789); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.47
# Mc/sec: 1561.14
//
Query:       EFC39583.1  [L=385]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.1e-12   46.7   0.0    9.5e-12   45.1   0.0    1.9  1  C2              C2 domain
  ------ inclusion threshold ------
      0.043   13.8   0.9        6.2    6.9   0.2    2.6  2  DiSB-ORF2_chro  Putative virion glycoprotein of insect viruse


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.1   0.0   1.1e-15   9.5e-12       4     100 ..       3     103 ..       1     105 [. 0.92

  Alignments for each domain:
  == domain 1  score: 45.1 bits;  conditional E-value: 1.1e-15
                 EEEEEEEESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEEEEEEEEESC..HTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHHTTHH CS
          C2   4 evtvieAknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWnekftfevae..leeakLeveVfdndrlskddfiGkveiplstllsgee 96 
                 +++ ++A nLp+ d  gs+d y+ v++       + +kT+v+kns +P+W  kft ++ +  + ++ + v ++d+d+++++df+ +++i++ +ll+  +
  EFC39583.1   3 HFKLHSASNLPKADTIGSIDGYALVKIpisgGLYTEFKTSVVKNSYDPKW--KFTCPIVHnpDTSRDVIVVIMDHDKVGQNDFVCHCRISFVNLLTPCR 99 
                 67899*****************9999999888889***************..7888777778999**************************99999988 PP

                 HHEE CS
          C2  97 aegw 100
                 ++ w
  EFC39583.1 100 KNTW 103
                 8888 PP

>> DiSB-ORF2_chro  Putative virion glycoprotein of insect viruses
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   0.2   0.00069       6.2      28      50 ..      64      86 ..      54      87 .. 0.88
   2 ?    4.8   0.0    0.0032        28      12      38 ..     283     309 ..     276     314 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00069
  DiSB-ORF2_chro 28 nCsdvsvvildktfyGqetvvCh 50
                       dv vvi+d+   Gq++ vCh
      EFC39583.1 64 TSRDVIVVIMDHDKVGQNDFVCH 86
                    567899****************9 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0032
  DiSB-ORF2_chro  12 VyRtndwfFqeCtLPPnCsdvsvvild 38 
                     +y  +d+fF +C+   + +d ++  ld
      EFC39583.1 283 IYMIEDYFFIKCDWDSSNGDEVIGLLD 309
                     78899*******988888777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (385 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 2398.87
//
Query:       EFC39584.1  [L=490]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.051   13.9   0.1        0.2   12.0   0.0    2.0  2  Desmo_N   Viral Desmoplakin N-terminus


Domain annotation for each model (and alignments):
>> Desmo_N  Viral Desmoplakin N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0      0.56     1e+04      43      64 ..     366     387 ..     360     402 .. 0.69
   2 ?   12.0   0.0   1.1e-05       0.2      24      70 ..     434     480 ..     424     488 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 0.56
     Desmo_N  43 vlilkPslkknsaemdalplli 64 
                 ++ + Psl+ n++   +    i
  EFC39584.1 366 IVQMVPSLRFNAITLRTRDDDI 387
                 7778888888888777665444 PP

  == domain 2  score: 12.0 bits;  conditional E-value: 1.1e-05
     Desmo_N  24 akiktledyeeklreihkvvlilkPslkknsaemdalpllimqflsd 70 
                 a++   +++   +  +h+ v+++kP  kkn+a+   l+ l  q+ls+
  EFC39584.1 434 ARLAQCQEFSISVHCLHNFVIAFKPNQKKNAAKKRMLQKLKEQLLSS 480
                 566777889999999**************************9*9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (490 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       653  (0.0364214); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2931.60
//
Query:       EFC39585.1  [L=370]
Description: actin binding protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-29  102.6   0.0    1.5e-14   53.9   0.0    2.2  2  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
  ------ inclusion threshold ------
       0.03   12.1   5.7      0.037   11.8   5.7    1.1  1  Retinal      Retinal protein
        3.9    5.8   6.5        5.4    5.3   6.5    1.1  1  Herpes_pp85  Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV U


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.8   0.0   3.8e-16   2.3e-12       2     120 ..      13     133 ..      12     134 .. 0.94
   2 !   53.9   0.0   2.4e-18   1.5e-14       2     118 ..     235     353 ..     234     355 .. 0.95

  Alignments for each domain:
  == domain 1  score: 46.8 bits;  conditional E-value: 3.8e-16
                  HHHHHHHCTTT..SSEEEEEEECTT.TEEEEEESS-.HHHHHHHHHHTTT-EEEEEEEEEECCSECCEEEEEEEEE--TTS-HHHHHHHHHHHHHHHH CS
  Cofilin_ADF   2 keafkelksgk.ktkyilfkidddk.eeivveeege.tyeelreelpeseprYavydveyehddeskrsklvfIswvPdsapikqkmlyasskdalkk 96 
                   +a+ +++s++  t+++++++ d   + ++++++ge  ++e++e+++ +++ Y++ ++e + d+ s + k+ f+ +v+d++++  ++ +  + +++ +
   EFC39585.1  13 ADAIADVRSDQtPTNWMVCGYVDGAvKVLELKAKGEgGVDEMKEQFKATNAYYGLARIEEMIDS-SLTIKFAFVKFVGDDLKPLLRAGITPQVGDITT 109
                  5899****************8777669999999999988********************99998.********************************* PP

                  HCTTSEEEEEE-CGGCCSHHHHHH CS
  Cofilin_ADF  97 elkgisveieatdldelteeelke 120
                  ++k ++v++ +t++de+++  ++e
   EFC39585.1 110 KFKPYHVDMYITSQDEISQHVIEE 133
                  ******************988765 PP

  == domain 2  score: 53.9 bits;  conditional E-value: 2.4e-18
                  HHHHHHHCTTT..SSEEEEEEECTT.TEEEEEESS-.HHHHHHHHHHTTT-EEEEEEEEEECCSECCEEEEEEEEE--TTS-HHHHHHHHHHHHHHHH CS
  Cofilin_ADF   2 keafkelksgk.ktkyilfkidddk.eeivveeege.tyeelreelpeseprYavydveyehddeskrsklvfIswvPdsapikqkmlyasskdalkk 96 
                  +ea+++++++   t+++ +++ +++ +++++  +ge  ++e++++   + + +++++v+   dd s++ k+vf++  +d++ ++ k  ++++k+++  
   EFC39585.1 235 QEAIRSVRNDGdATNWMSITYAPNSkTKLTLLGKGEgGVDEMKDSWGPTGVYFGLVRVTEIIDD-SETVKFVFVHMLGDNVHPMLKGRVSTHKGQVEA 331
                  799******999**********99978899989999988*******888**********99998.********************************* PP

                  HCTTSEEEEEE-CGGCCSHHHH CS
  Cofilin_ADF  97 elkgisveieatdldelteeel 118
                   l+ ++ ++++t++de+++eel
   EFC39585.1 332 LLQPYHTTFFTTNKDEISQEEL 353
                  ********************97 PP

>> Retinal  Retinal protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   5.7   6.3e-06     0.037    1028    1087 ..     157     214 ..     127     237 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 6.3e-06
     Retinal 1028 radkrqkslpsshrp.aqpslptvqsspspplsprapsPpasprvlspptskkrtsppaqh 1087
                    + rq+ l s+ +  +q+s++++ + +sp++s++++sP +s+ +++ p s   +sp +  
  EFC39585.1  157 DNEERQRRLDSHVKLqQQSSSSSTVGTSSPTTSTATSSPVRSASTTTRPVS---SSPRPST 214 
                  4566778888888764778889999****************9999998887...4444443 PP

>> Herpes_pp85  Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   6.5    0.0009       5.4     420     521 ..     118     211 ..     101     222 .. 0.59

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0009
  Herpes_pp85 420 veevelqrlsavvieavarktGlslkrviekldraplgqesepeitegrdlfadvfrrpvtdaaasssassssssasPnsvslpsdrssstrtrvPas 517
                  +       +s  vie    k  +s  +v+ek +   +        +e+r+   d   +   ++ +ss+  +ss + s    s p  rs+st t  P+s
   EFC39585.1 118 MYITSQDEISQHVIEELVGKASMSRSNVMEKHEGEKIQ-----RDNEERQRRLDSHVKLQQQSSSSSTVGTSSPTTSTAT-SSP-VRSASTTT-RPVS 207
                  5555566899999999999***********99984443.....3355554455555555555555555555544444444.223.35555433.2444 PP

  Herpes_pp85 518 syss 521
                  s  +
   EFC39585.1 208 SSPR 211
                  4333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1169  (0.0652016); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.72u 0.36s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 2018.56
//
Query:       EFC39586.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0041   17.2   0.9     0.0055   16.7   0.9    1.1  1  DUF5391   Family of unknown function (DUF5391)


Domain annotation for each model (and alignments):
>> DUF5391  Family of unknown function (DUF5391)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.9   3.1e-07    0.0055      44     124 ..      88     170 ..      77     178 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 3.1e-07
     DUF5391  44 nslgmwksiGiillfylvpl....llyilgikalrfvmailcgvGllidlvllavvflslllsdseassllgvivlciasiivnv 124
                 ns+gm      + lfy++ +    ++yi g+   rfv  +l+g+  +++  ++  +   + ++++ea  ++  +  c   i+  v
  EFC39586.1  88 NSMGMRLKF--VYLFYFLMVgslgFIYIDGVTQTRFVFYVLIGAEFILNSLVIRNIERNIPMAKKEALNMFMTLFSCANRIVLQV 170
                 666766554..555555543333579******************************99999999999888888889988887665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       493  (0.0274974); expected 358.6 (0.02)
Passed bias filter:                      289  (0.0161191); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.54
# Mc/sec: 996.76
//
Query:       EFC39587.1  [L=667]
Description: histidine kinase ATPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    9.7e-18   64.4   1.4    3.8e-17   62.5   0.1    2.6  4  Response_reg  Response regulator receiver domain
    6.1e-16   58.9   0.0      2e-15   57.2   0.0    2.0  1  HATPase_c     Histidine kinase-, DNA gyrase B-, and HSP90-lik
    1.5e-07   31.4   1.3    1.2e-06   28.4   0.0    2.5  2  HisKA         His Kinase A (phospho-acceptor) domain


Domain annotation for each model (and alignments):
>> Response_reg  Response regulator receiver domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.5   8.9e+03      65     100 ..      94     129 ..      92     140 .. 0.70
   2 ?   -3.1   0.0       1.5     9e+03       1      19 [.     401     419 ..     401     444 .. 0.76
   3 ?   -1.0   0.0      0.33     2e+03      77     104 ..     438     465 ..     418     471 .. 0.82
   4 !   62.5   0.1   6.4e-21   3.8e-17       2     111 ..     549     661 ..     548     662 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.5
                   HHHCTTTSEEEEEESSTSHHHHHHHHHCTESEEEES CS
  Response_reg  65 ireedpelpviiltahseeedavealkagaddflsK 100
                   +r+++++lp  ilt+ +  ed+    +++a+ +++ 
    EFC39587.1  94 MRRRKNSLPSSILTSSECLEDLSIDHSIDANTIIAS 129
                   788888899999998888887777777777777665 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 1.5
                   EEEESSSHHHHHHHHHHHH CS
  Response_reg   1 vlivdDdplvrellrqlle 19 
                   + ivd +  +r++l+++l+
    EFC39587.1 401 IYIVDSNICLRRVLTDYLR 419
                   6789999999999998887 PP

  == domain 3  score: -1.0 bits;  conditional E-value: 0.33
                   EESSTSHHHHHHHHHCTESEEEESSG-H CS
  Response_reg  77 ltahseeedavealkagaddflsKpfdp 104
                   ++ ++ ++ ++  ++ +++d ++K+f+ 
    EFC39587.1 438 ISNTDVNKLLITIYSDEMNDSIQKQFES 465
                   6667777888899999999****99975 PP

  == domain 4  score: 62.5 bits;  conditional E-value: 6.4e-21
                   EEESSSHHHHHHHHHHHHHTTEEEEEEESSHHHHHHHHHHHH..ESEEEEESSCSSSEHHHHHHHHHHCT..TTSEEEEEESSTSHHHHHHHHHCTE CS
  Response_reg   2 livdDdplvrellrqlleeegyeevaeaedgkealellkeek..vdlillDinmpgmdGlellkeireed..pelpviiltahseeedavealkaga 94 
                   l+vdD++++r++l+++l+  g+ e+++ae+g  a+e++ke+   + +i++D+ mp ++G e ++ ir++   +++ ++++ta+   e+++   +ag 
    EFC39587.1 549 LVVDDNEINRKVLQKMLKMVGFDEIDVAENGLVAFEKFKENPtkYRIIFMDLLMPFVSGKESCELIRNHTtkSNTLIVAVTANIW-ETKEMLCQAGF 644
                   8*************************************998888*************************9555566666666654.6666667**** PP

                   SEEEESSG-HHHHHHHH CS
  Response_reg  95 ddflsKpfdpeeLlkal 111
                   d ++ Kp+  ++L k l
    EFC39587.1 645 DSVIYKPILLNNLQKEL 661
                   ********999998865 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.2   0.0   3.4e-19     2e-15       1     110 [.     211     368 ..     211     370 .. 0.81

  Alignments for each domain:
  == domain 1  score: 57.2 bits;  conditional E-value: 3.4e-19
                 EHHHHHHHHHHHHHHHHHHHHSTTTEEEEEEEE...................EE...........TEEEEEEEESSSSSTTHHHTGTCSTTCH...... CS
   HATPase_c   1 gdekrLrqiisnlvdNavkfatkageieveika...................se...........ddlvisveDnGiGipkedlkklfekfsq...... 63 
                 gd+ ++ q++ n+++N++k+ tk+g + ++++                    ++           + l+i   D+G Gi+ + +k lf++f +      
  EFC39587.1 211 GDQVKISQVLMNIISNSIKY-TKKGYVMITCDLckdtdfakfgldekalksiRDnltlgneeeevVFLKINCNDTGLGISLNSMKTLFKPFRTienssp 308
                 68999***************.********88888777766666655555444014444455667889999***************99999999999999 PP

                 ............HCSTCHT....STSSSHHHHHHHHHHHHTTTEEEEEEETTTEEEEEEEEES CS
   HATPase_c  64 ............ddstkrg....gggtGlGlsivkklvelmgGeiwvesepgrGttftftlpl 110
                             + +        + ++GlGlsi+k++++ m+G+i vese g Gt + + lpl
  EFC39587.1 309 sfeqyyskyenqK-EI--AnssfSDRNGLGLSICKRFCDVMHGKIGVESEVGNGTNISILLPL 368
                 9988887776632.22..1345569**********************************9998 PP

>> HisKA  His Kinase A (phospho-acceptor) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.0     2e-10   1.2e-06       1      46 [.      45      87 ..      45      96 .. 0.88
   2 ?    1.1   0.3     0.069   4.1e+02      18      65 ..     103     161 ..     103     163 .. 0.62

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 2e-10
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHC..T-HSSCHHHHHHHHH CS
       HisKA  1 slgrflagvaHELrtPLsailgnaeaLkregklteelkeyleties 46
                s+++f+ +++HE r+PL+++ g +++Lk      e+l ++ e+  +
  EFC39587.1 45 SKTKFIGNLSHEVRNPLHGVVGSIQILKH---EAERLNRFTESSLR 87
                799************************99...57999998887665 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.069
                 HHHHHHHHHHHC.............T-HSSCHHHHHHHHHHHHHHHHHHHHHHHHCCHH CS
       HisKA  18 sailgnaeaLkre...........gklteelkeyletiesearrldhlvedlLdlsrie 65 
                 s+il  +e L++            ++ +++  e++++i +++  l+++ ++ L+ls +e
  EFC39587.1 103 SSILTSSECLEDLsidhsidantiIASNQSSVELIDDIYNNSILLLNIFSRSLQLSNLE 161
                 67888888888866555555555555555666666666666666666666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (667 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1009  (0.0562775); expected 358.6 (0.02)
Passed bias filter:                      552  (0.0307881); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.30s 00:00:01.03 Elapsed: 00:00:00.49
# Mc/sec: 4075.27
//
Query:       EFC39588.1  [L=457]
Description: cofactor-independent phosphoglycerate mutase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-49  168.1   0.0    2.6e-49  167.4   0.0    1.4  1  PhosphMutase   2,3-bisphosphoglycerate-independent phosphogly
    7.2e-31  107.4   0.0    8.9e-31  107.1   0.0    1.0  1  Metalloenzyme  Metalloenzyme superfamily
    0.00025   20.8   0.0      0.025   14.2   0.0    2.2  2  Phosphodiest   Type I phosphodiesterase / nucleotide pyrophos
  ------ inclusion threshold ------
      0.022   14.2   0.0       0.31   10.4   0.0    2.1  2  Sulfatase      Sulfatase


Domain annotation for each model (and alignments):
>> PhosphMutase  2,3-bisphosphoglycerate-independent phosphoglycerate mutase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  167.4   0.0   5.8e-53   2.6e-49       1     170 []      55     239 ..      55     239 .. 0.97

  Alignments for each domain:
  == domain 1  score: 167.4 bits;  conditional E-value: 5.8e-53
                   HHTSEEEEEE-----------TCHHHHTT--HHCH---HHHHHHHHTT----TT-EEEEEEEEEEC..TTCEEETTGGG-.-TTHHHHHHHT-EEE. CS
  PhosphMutase   1 AkkGetGlldtvpegiapgSdvAnlsilGydpkkyytGRGplEAlgiGlelkpgdvafRcnlvtvdeedgiiidrragristeeakeLikalneel. 96 
                   A+ G+ Gl+d+v++g+a+gSd+A++si+Gydp+ +y+GRG +E +g+Gl+++pgd+af++n++t++++++i++ rra+r+++e ++ L+++l++++ 
    EFC39588.1  55 AACGVNGLMDPVQPGLACGSDTAHMSIFGYDPRLHYKGRGSFETIGAGLDMSPGDIAFKSNFATWNSKTNIVELRRADRHFEEMGPILCDYLQQQCe 151
                   788********************************************************************************************** PP

                   .......TTEEEEEEE-STTEEEEEE....--S-B--S--..SSTTS------BS.......SGGGHHHHHHHHHHHHHHHHHHHHSHHH CS
  PhosphMutase  97 ......eegvevkfypgveyrhllvl....lsdkitdtdpphdkegkeikellplk......seeaketaellnelieksqeiLedhpvN 170
                         +++++v++++++e+r+ + +    ls +it tdp   +++ e+ ++ p+k       e+ak+t++l+n+l++ ++e L++h++N
    EFC39588.1 152 ekgfnaKHNCTVSIKYATEHRCGVKVsgknLSGDITGTDP--LVDDLELVKCEPVKglkgeeLEKAKRTSDLVNDLSHFIYEQLSKHEIN 239
                   ****95499*******************************..************967999987799***********************9 PP

>> Metalloenzyme  Metalloenzyme superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.1   0.0     2e-34   8.9e-31       3     221 ..      21     410 ..      19     437 .. 0.93

  Alignments for each domain:
  == domain 1  score: 107.1 bits;  conditional E-value: 2e-34
                    EEEEEETTBB----GGGTT...HHHS--HHHHHHHHH.......SEEEEEESSSTT----HHHHHHHH............................ CS
                    xxxxxxxxxxxxxxxxxxx...xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............................ RF
  Metalloenzyme   3 vvlvvlDGlGeapadelna...ihvAktPtldkLkkeaPerwlikahgtavglpeddmgnsevgHlel............................ 67 
                    +  v +DG+Ge + +el+    ++ A+tP++d+L++        + +g++ +++ +   +s+++H+++                            
     EFC39588.1  21 ICFVMIDGIGEVNIEELGKktaLQSAQTPNMDRLAAC-------GVNGLMDPVQPGLACGSDTAHMSIfgydprlhykgrgsfetigagldmspgd 109
                    678999********87766666*************99.......89************************************************** PP

                    ................................................................................................ CS
                    ................................................................................................ RF
  Metalloenzyme  68 ................................................................................................ 67 
                                                                                                                    
     EFC39588.1 110 iafksnfatwnsktnivelrradrhfeemgpilcdylqqqceekgfnakhnctvsikyatehrcgvkvsgknlsgditgtdplvddlelvkcepvk 205
                    ************************************************************************************************ PP

                    ...................................HHHHTT-----EEEEEEEE-S---SS.HHHHHT--EEEE--SHH................. CS
                    ...................................xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxx................. RF
  Metalloenzyme  68 ...................................lrisetvkfahvtffwnggrsgyfnp.leereeipsdtvitfdl................. 110
                                                       +r +e+++ a+++++++ g+  +++p  e+  ++++  v+++ +                 
     EFC39588.1 206 glkgeelekakrtsdlvndlshfiyeqlskheinkQRKQEGKNEANIVLLRGCGVCIDVPPfSERHPGLRGMLVAPTAIiaglgksvgmelkkveg 301
                    ***********************************999***********************6677789**************************** PP

                    ...STT--HHHHHHHHHHHH.C.C.-SEEEEEE-HHHHHHHTT-HHHHHHHHHHHHHHHHHHHTTS-TTTE..EEEEE-SSB--TTTSS....... CS
                    ...xxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxx RF
  Metalloenzyme 111 ...qpemkavevaekaldails.gkfdlvvvniknaDmvGHtgdleatiaaieaaDeavkeildaieqvdg..ilvvtADHgnaedmvkrdkqplT 200
                         +++  ++ +  l+ + + ++f++ +++ik  D  GH+g++  + + ie+ D+++++++d+ e+ ++  ++v+t+DH+++  +++       
     EFC39588.1 302 asgDYRTNLTKKGKGFLEHLVNgDEFNFGFCHIKAVDDTGHDGNFVLKKEFIEKSDQMIGMLMDEFEKRKQrvVFVITGDHSTPCYYKD------- 390
                    ***999999999999999986515799**************************************9986642289**************....... PP

                    .-----EEEEEESTT----S- CS
                    xxxxxxxxxxxxxxxxxxxxx RF
  Metalloenzyme 201 sHtlepVPilivgkglapdkv 221
                     H+ epVP++i g+ l+ ++ 
     EFC39588.1 391 -HSYEPVPLIISGNYLNLEQY 410
                    .************99986444 PP

>> Phosphodiest  Type I phosphodiesterase / nucleotide pyrophosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.5   0.0    0.0047        21      19      42 ..      46      68 ..      22      81 .. 0.82
   2 !   14.2   0.0   5.6e-06     0.025     170     233 ..     321     383 ..     226     397 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0047
                  STSHHHHHHHHHSEEESEEE-SSS CS
  Phosphodiest 19 ellpnlaaLakegvsapnlrpvfP 42
                    +pn+++La +gv++  ++pv P
    EFC39588.1 46 AQTPNMDRLAACGVNGL-MDPVQP 68
                  49***************.999987 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 5.6e-06
                   T...SSESEEEEEECCCHHHHHHH-TTSHHHHHHHHHHHHHHHHHHHHHHHTTGTTTEEEEEEES-- CS
  Phosphodiest 170 l...ekpdlllvyleetDtvgHkfGpdspevedalrrvDkaigdLlealderglsaetniilvSDHG 233
                   l   ++ ++ ++++ ++D  gH    +    ++ +++ D++ig L+++ ++r  ++ + +++++DH 
    EFC39588.1 321 LvngDEFNFGFCHIKAVDDTGHDG--NFVLKKEFIEKSDQMIGMLMDEFEKR--KQRVVFVITGDHS 383
                   246699999999**********65..4344578999****************..99**********7 PP

>> Sulfatase  Sulfatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0     0.039   1.7e+02       4      37 ..      22      59 ..      20      63 .. 0.84
   2 ?   10.4   0.0   6.9e-05      0.31     217     255 ..     352     388 ..     345     423 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.039
                EEEEESSE-TTGSGGGTTTSCS....SHHHHHHHHTSE CS
   Sulfatase  4 vliladdlgagdlglyggktat....tpnldrlaeegl 37
                 ++++d  g  +++  g kta     tpn+drla+ g+
  EFC39588.1 22 CFVMIDGIGEVNIEELGKKTALqsaqTPNMDRLAACGV 59
                58999999999999999999666667********7766 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 6.9e-05
                 HHHHHHHHHHHHHHHHHHTTTGGGEEEEEEESSSSCCCG CS
   Sulfatase 217 sveyvDdligrvlaaLeenglldntlvvftSDhgaslee 255
                 ++e  D++ig +++++  ++ ++ +++v+t+Dh    + 
  EFC39588.1 352 FIEKSDQMIGMLMDEF--EKRKQRVVFVITGDHSTPCYY 388
                 7899************..999999*********988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (457 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       546  (0.0304535); expected 358.6 (0.02)
Passed bias filter:                      457  (0.0254894); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2660.12
//
Query:       EFC39589.1  [L=799]
Description: CAMK family protein kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.1e-28  100.3   1.4    2.3e-28   99.3   1.4    1.5  1  Pkinase         Protein kinase domain
    3.6e-19   69.1   0.1    7.4e-19   68.0   0.1    1.5  1  Pkinase_Tyr     Protein tyrosine kinase
    1.9e-08   33.9  44.8    0.00022   20.9   1.7    8.7  8  DUF4116         Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.045   13.1   0.0      0.082   12.3   0.0    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
       0.14   12.2   1.4       0.35   10.9   0.0    2.4  3  Glyco_hydro_4C  Family 4 glycosyl hydrolase C-terminal domain


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.3   1.4   6.5e-32   2.3e-28       5     212 ..      91     299 ..      88     370 .. 0.79

  Alignments for each domain:
  == domain 1  score: 99.3 bits;  conditional E-value: 6.5e-32
                 EEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHH CS
     Pkinase   5 eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseeeakki 103
                 +k+GeG+ G Vy ++  + + + AvK+i+  +++ ++    + E+  ++klkh++i+++ +++  ++e+++ ++y e+g+l+++ +   +l+  ++ +i
  EFC39589.1  91 KKIGEGGGGDVYLVK--KGNTMKAVKHIRSFSNEYSR----FDEVFQIAKLKHDHIIEIDDYYLINNEFCFEMDYYEKGSLETYKN---KLTVGQLFQI 180
                 89*************..67788899999988777655....69***************************************9998...5********* PP

                 HHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH..........TTSCBSHHHHHHHHHHHHH CS
     Pkinase 104 akqilegleylHskgiiHrDlKpeNiLidekge....lKitDFGlakelessskltsfvgtseYlAPEvl..........keneyskkvDvWslGvily 188
                 a qi ++++y+ +++++HrD+K +NiL++e  +    + +tDFG++ + +s ++++  +gt++Y  PE+            e ++++++D+++lGv+l 
  EFC39589.1 181 ACQISSAIKYISEQELCHRDVKIANILVKEITDsniyVVLTDFGVSFKKNSYKPYQFKTGTEQYYDPEIEkyfntekrglLEFPFKTETDLYALGVTLE 279
                 *****************************64334588********************************97777654433347889************9 PP

                 HHHHSS-STTTSSHHHHHHHHHHT CS
     Pkinase 189 elltgkppfsgekgkekvekeldq 212
                  l +++++ s    ke    +++ 
  EFC39589.1 280 RLSNKTTINSTPLLKE----IITS 299
                 9988888776322222....2222 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.0   0.1   2.1e-22   7.4e-19       5     199 ..      91     282 ..      88     340 .. 0.81

  Alignments for each domain:
  == domain 1  score: 68.0 bits;  conditional E-value: 2.1e-22
                  EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSBH CS
  Pkinase_Tyr   5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekltl 102
                  kk+GeG  G+V+  +        ++  avK +++ ++e    + ++e+  + klkh++i+++   ++ +++ ++ ++y ++G+L+++     k+klt+
   EFC39589.1  91 KKIGEGGGGDVYLVKKG------NTMKAVKHIRSFSNEY---SRFDEVFQIAKLKHDHIIEIDDYYLINNEFCFEMDYYEKGSLETY-----KNKLTV 174
                  78999999999987655......6677999997766666...678999999**********************************98.....5689** PP

                  HHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..........EEHHH CS
  Pkinase_Tyr 103 kdllsfalqvAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk..........ftsks 186
                   +l+++a q++++++y+++++l Hrd+   N+L++e    n  v ++DfG++ + +   +y+  + ++   +++ pE+ k+ +          f++++
   EFC39589.1 175 GQLFQIACQISSAIKYISEQELCHRDVKIANILVKEitdsNIYVVLTDFGVSFKKN---SYKPYQFKTGTEQYYDPEIEKYFNtekrgllefpFKTET 269
                  ***********************************98887889*********9884...4444445555567888887665555578999999***** PP

                  HHHHHHHHHHHHH CS
  Pkinase_Tyr 187 DvWsfGvllwEif 199
                  D ++ Gv+l  + 
   EFC39589.1 270 DLYALGVTLERLS 282
                  *******996554 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.17     6e+02      11      22 ..     183     194 ..     178     209 .. 0.74
   2 !    7.3   1.0    0.0011       3.9       6      48 ..     339     379 ..     338     390 .. 0.85
   3 !   20.9   1.7   6.1e-08   0.00022       1      49 []     466     512 ..     451     512 .. 0.98
   4 !    5.3   0.8    0.0046        17       6      49 .]     521     570 ..     518     594 .. 0.72
   5 !    6.1   3.1    0.0026       9.2       1      48 [.     625     671 ..     625     672 .. 0.77
   6 ?    1.5   0.3     0.069   2.5e+02      15      29 ..     663     677 ..     650     683 .. 0.72
   7 ?    4.1   0.1     0.011        40      13      42 ..     710     738 ..     695     744 .. 0.71
   8 !   13.2   1.3   1.6e-05     0.056       1      30 [.     746     775 ..     746     776 .. 0.97

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.17
     DUF4116  11 kngsalkylsee 22 
                 + +sa+ky+se 
  EFC39589.1 183 QISSAIKYISEQ 194
                 557899999975 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0011
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 l+a+  n++++ +++  + ++k ++ k + +n +++++++++L
  EFC39589.1 339 LHACVMNPNCFIFCP--YNKNKRFIYKVLDINHHIFEMVPDDL 379
                 567777899999999..55899999999999999999999998 PP

  == domain 3  score: 20.9 bits;  conditional E-value: 6.1e-08
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +r iv   +kk  ++++++s  ++ D ei+   +++n++++ ++s eLr
  EFC39589.1 466 NRNIVFSFIKKVEECFQHCS--YRDDEEIIQYVLEKNPKFITFISFELR 512
                 799*****************..9************************98 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.0046
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngt......alsyaseeLr 49 
                 +e+++ ++s +  lse   +D+ +++ A+k +++      +++ ++e+L+
  EFC39589.1 521 KEILEVDPSFYSSLSEISLKDRLFAKLAMKGCKSqrdfdsNFDCLPEDLK 570
                 67777788888888877777887777776666555555667777777765 PP

  == domain 5  score: 6.1 bits;  conditional E-value: 0.0026
     DUF4116   1 DrEivleavkkngsalkyls.eeLknDkeivlkAvkqngtalsyaseeL 48 
                 D E+v +++++ +  +++ls ++Lk + ei+++    n t ++++s++L
  EFC39589.1 625 DIELVNQIIEISPDLYENLScNNLK-NNEIIIETYL-NHTYYPRLSKDL 671
                 89******************77788.6666666665.444567777776 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.069
     DUF4116  15 alkylseeLknDkei 29 
                 ++  ls++Lk D e+
  EFC39589.1 663 YYPRLSKDLKLDDEF 677
                 5777********998 PP

  == domain 7  score: 4.1 bits;  conditional E-value: 0.011
     DUF4116  13 gsalkylseeLknDkeivlkAvkqngtals 42 
                 g+ l+  s++L  Dke++l ++++ + a+ 
  EFC39589.1 710 GLLLYLESKDL-DDKEFMLPILEKFPRAYL 738
                 55555556555.699999999998888875 PP

  == domain 8  score: 13.2 bits;  conditional E-value: 1.6e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeiv 30 
                 D+Ei++ +++kn ++++ l+  +++D ei+
  EFC39589.1 746 DKEIIKMVIRKNDEIYEDLDTTFQKDEEIL 775
                 9***************************96 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   2.3e-05     0.082     123     167 ..     180     224 ..     162     233 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.3e-05
         Kdo 123 llkavgrliaklhragvnHadlyaknillqqeeeeeaeiwliDld 167
                 +  ++  +i+ + + +++H+d+ + nil+++  + ++ ++l D+ 
  EFC39589.1 180 IACQISSAIKYISEQELCHRDVKIANILVKEITDSNIYVVLTDFG 224
                 556899999***********************9999999999995 PP

>> Glyco_hydro_4C  Family 4 glycosyl hydrolase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0      0.72   2.6e+03      58     124 ..      32     121 ..      31     146 .. 0.41
   2 ?   -2.2   0.1         1   3.7e+03      52      69 ..     444     460 ..     367     525 .. 0.59
   3 ?   10.9   0.0   9.7e-05      0.35       2      79 ..     600     686 ..     599     768 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 0.72
                     ECGGHHCTTSS..HCHHHH...SHHHHHHH..........HHHHHHHHHHHTTTTTHHHHHHH............SSCHTS-SHHHHHHHHHH CS
  Glyco_hydro_4C  58 teysrhyaEYvp.ylkrea...peliekek..........traevvkevekelfeelekekle............lekrsgeyavdiieaivt 124
                     t++  h+  ++p  +++ +   ++l++             ++ae  +++e+ l++++ ++  +            ++k ++ +av+ i++  +
      EFC39589.1  32 TSGPTHF--FMPeTYEQAIpkkKKLMDY-VnidienkvqlPEAESRNAIEHYLTTNVGASYCKkigeggggdvylVKKGNTMKAVKHIRSFSN 121
                     5566677..5555333222221122221.0232221222222222222333333333222222333444444444444444445555555544 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1
                     HHSSEEECGGHHCTTSS. CS
  Glyco_hydro_4C  52 rlgllpteysrhyaEYvp 69 
                     +l++l+   sr++  Y+p
      EFC39589.1 444 QLEILVYYNSRFF-KYFP 460
                     2223333333333.3333 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 9.7e-05
                     EEETTEEEEEEEECTTEEHHHHHHHHHHH.HHHHHHCTGGGTSHHHHHHHHHHSSEEECGGHHCTTSS............HCHHHHSHHH CS
  Glyco_hydro_4C   2 aGlNHlaWllkledkGeDlypelrelvee.dewleeiaekkaervridllrrlgllpteysrhyaEYvp...........ylkreapeli 79 
                      G  Hl+   +++++G++l+++  + +e  ++ +e   +   e+ +++ l++ ++++ +y++h+  Y p           ++ ++ ++li
      EFC39589.1 600 QGFSHLIHAIEVKEQGNELMQKCSDDIELvNQIIEISPDL-YENLSCNNLKNNEIIIETYLNHT--YYPrlskdlklddeFQAKHLKKLI 686
                     5889*********99********99887643333333333.677999*****************..888655544333332222223333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (799 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       990  (0.0552178); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.77u 0.38s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 4372.17
//
Query:       EFC39590.1  [L=362]
Description: hypothetical protein NAEGRDRAFT_60876 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   1.1e-120  403.0   0.0   4.7e-120  400.9   0.0    1.9  1  Actin     Actin


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  400.9   0.0  2.6e-124  4.7e-120       3     407 .]       3     362 .]       1     362 [] 0.96

  Alignments for each domain:
  == domain 1  score: 400.9 bits;  conditional E-value: 2.6e-124
       Actin   3 evsavVlDnGssttraGyagedaPkavipslvgkprgrkveaklyvgdealtkrpelevrspvedGvvedwdaveelwehvlkeelkvdpeehplllte 101
                 e+ a+V+DnGs++++aG++g+daP++v+ps++g+p++ ++++++yvgdea++kr+ l++r+p+++G+v++wd++e++w h++++el+v pee+p+l++e
  EFC39590.1   3 EEVALVIDNGSGMCKAGFSGDDAPRVVFPSIIGQPKHLSEMSEFYVGDEAQSKRGLLNLRNPINQGIVNNWDDMERIWFHTFYNELRVAPEEYPILMSE 101
                 6779*********************************************************************************************** PP

       Actin 102 pplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairrsdlgGkaLteqlkellssknvevtpryli 200
                  +ln +++re + +i+fEkf vpaly+a+ avl+++asgkstg++v+sG+sv          +L +ai ++dlgG++Lt++l+++l+++          
  EFC39590.1 102 VSLNLKTNREMMSQIMFEKFCVPALYVANRAVLALYASGKSTGMIVNSGDSV----------MLCHAILKMDLGGRDLTNYLMKMLTER---------- 180
                 *************************************************875..........7999**********************8.......... PP

       Actin 201 kkkkvveaessaekeelekltesyktleeeevleeiKesvcevsedpeg....deekss....sspeksYeLPDgseiklgeeRfkvpEiLFdpsligs 291
                                     ++ +++++e+e++++ Ke++c+ + d+++              +  +k Y +P+g++++lg+eRf++pEiLF+p++i  
  EFC39590.1 181 --------------------GYTFTNTAEREIVRDRKEKLCYLALDFQEemnsV----VreepTIDRKLYDIPEGNVVTLGNERFRCPEILFHPNMIDV 255
                 ....................9**************************9654332....14454788888****************************** PP

       Actin 292 esaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvs 390
                 es+        +gi+e+++++i +cd+d+r+eL+ ni ++GGn++++g+t+R++kel++la++++++k++ap+ erkys+WiGGS+LA  +tf++ w++
  EFC39590.1 256 ESK--------VGIHEMTFNSIGQCDPDIRKELFGNIFLSGGNTMFEGITDRMSKELTALAPESFNIKVTAPP-ERKYSTWIGGSMLALSSTFKDNWMT 345
                 999........9*************************************************************.************************* PP

       Actin 391 kqEYeEqGssvverkck 407
                 +++YeE G+ +++rkc+
  EFC39590.1 346 REDYEEVGPAIIHRKCF 362
                 ****************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       305  (0.0170115); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 2032.47
//
Query:       EFC39591.1  [L=182]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-65  219.2   0.2    2.7e-65  219.1   0.2    1.0  1  Arf            ADP-ribosylation factor family
      5e-14   52.2   0.0    5.5e-14   52.1   0.0    1.1  1  Ras            Ras family
    1.5e-13   50.6   1.6    5.1e-11   42.3   0.5    2.3  2  G-alpha        G-protein alpha subunit
      8e-13   48.2   0.1      1e-12   47.9   0.1    1.0  1  SRPRB          Signal recognition particle receptor beta subu
    1.7e-12   47.6   0.2    2.5e-12   47.1   0.2    1.2  1  Roc            Ras of Complex, Roc, domain of DAPkinase
    3.1e-09   36.5   0.1    3.9e-09   36.2   0.1    1.1  1  Gtr1_RagA      Gtr1/RagA G protein conserved region
    0.00057   19.9   0.0    0.00084   19.4   0.0    1.2  1  MMR_HSR1       50S ribosome-binding GTPase
  ------ inclusion threshold ------
      0.068   12.0   0.1      0.083   11.7   0.1    1.1  1  DUF1015        Protein of unknown function (DUF1015)
       0.13   11.1   0.0       0.17   10.8   0.0    1.1  1  Vmethyltransf  Viral methyltransferase


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  219.1   0.2   1.4e-68   2.7e-65       5     174 ..      15     181 ..      11     182 .] 0.97

  Alignments for each domain:
  == domain 1  score: 219.1 bits;  conditional E-value: 1.4e-68
                 HHGGTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHH CS
         Arf   5 laklklkkkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakee 103
                 l+ l++ +ke++il+lGLD+aGKt  l+k++l+e v+t+PTigfn e +++k+++f+v+D+GGq+k+R+lW++Y+++t+a+if+vDs+d+eR++ea e 
  EFC39591.1  15 LKGLFE-NKEAKILFLGLDAAGKTSALYKIQLDENVSTIPTIGFNAEVIQYKKVTFRVFDIGGQDKIRKLWRHYYQSTNAIIFIVDSNDTERFKEAAET 112
                 677777.9******************************************************************************************* PP

                 HHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 104 LkalleeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlses 174
                 L+++++++ lk+++llv+aNKqDlp a++ +++ ++l+l+e+k  ++++iq csa++g+gl egl+wls++
  EFC39591.1 113 LREVMQDDLLKDAKLLVWANKQDLPRAANVKDMVNTLKLHEIK--QEWYIQPCSALSGNGLFEGLDWLSSK 181
                 *******************************************..9**********************976 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.1   0.0   2.8e-17   5.5e-14       1     149 [.      25     171 ..      25     182 .] 0.82

  Alignments for each domain:
  == domain 1  score: 52.1 bits;  conditional E-value: 2.8e-17
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++++G  a GKts l++   d+   + ++Tig++  +    ++ k+v+++++D  Gq++ ++l + yy+++++i+ + d +++e f+++++ ++e+ +
  EFC39591.1  25 KILFLGLDAAGKTSALYKIQLDENV-STIPTIGFNAEV----IQYKKVTFRVFDIGGQDKIRKLWRHYYQSTNAIIFIVDSNDTERFKEAAETLREVMQ 118
                 899**************98888855.669***887654....66799********************************************99999887 PP

                 HST.TTSEEEEEEETTTGGGG-SS-HH.HHHHHHHHHTSEEEE.EBTTTTCTH CS
         Ras 100 vae.envpivLvGnKvDleekravste.egeelakelglkfle.tSAktnenv 149
                     ++ ++++ +nK Dl +  +v+   +  +l++ ++  +++ +SA + +++
  EFC39591.1 119 DDLlKDAKLLVWANKQDLPRAANVKDMvNTLKLHEIKQEWYIQpCSALSGNGL 171
                 666689*************9888875514455666555555544888877766 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.3   0.0    0.0011       2.3      22      45 ..      22      45 ..      16      51 .. 0.87
   2 !   42.3   0.5   2.6e-14   5.1e-11     186     281 ..      52     136 ..      46     140 .. 0.94

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0011
                .EEEEEEEESTTSSHHHHHHHHHH CS
     G-alpha 22 revkllllGqseSGKsTilkqlkl 45
                +e k+l+lG +  GK++ l +++l
  EFC39591.1 22 KEAKILFLGLDAAGKTSALYKIQL 45
                589****************99995 PP

  == domain 2  score: 42.3 bits;  conditional E-value: 2.6e-14
                 ----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHH CS
     G-alpha 186 lktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDi 281
                 ++t+G++   ++++ k++fr++d+gGq + rk W +++++++aiiF+v           ++ + r++e+ +  +e+++  llk++++++  nK D+
  EFC39591.1  52 IPTIGFNAEVIQYK-KVTFRVFDIGGQDKIRKLWRHYYQSTNAIIFIVD----------SNDTERFKEAAETLREVMQDDLLKDAKLLVWANKQDL 136
                 789**********9.********************************97..........67789******************************97 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.9   0.1     5e-16     1e-12       2     137 ..      22     149 ..      21     158 .. 0.86

  Alignments for each domain:
  == domain 1  score: 47.9 bits;  conditional E-value: 5e-16
                 ---EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHH CS
       SRPRB   2 skpavllvGlsdsGKTslftrLttdsvkktvtSq.essaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEll 99 
                 ++ ++l++Gl  +GKTs + ++  d+  +t   +  +  + ++   k+ ++++ D+ G++k+r kl  +  + +s  +++f+vDS  d  + ke AE l
  EFC39591.1  22 KEAKILFLGLDAAGKTSALYKIQLDENVSTIPTIgFNAEVIQY---KKVTFRVFDIGGQDKIR-KLWRH--YYQSTNAIIFIVDSN-DTERFKEAAETL 113
                 56789**************************999778888888...9***************9.56666..678899*******97.7888******** PP

                 HHHHHHHHHHTT---EEEEEE-TTSTT---HHHHHHHH CS
       SRPRB 100 yeilliteklkdavdiliACnKqelflakspklikdaL 137
                  e++ +  + k   ++l+  nKq+l  a + k + + L
  EFC39591.1 114 REVMQDDLL-K-DAKLLVWANKQDLPRAANVKDMVNTL 149
                 ****99984.4.45799999****99887777666655 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.1   0.2   1.2e-15   2.5e-12       1     119 [.      25     135 ..      25     136 .. 0.76

  Alignments for each domain:
  == domain 1  score: 47.1 bits;  conditional E-value: 1.2e-15
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHH.. CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssenlke.. 97 
                 K++++G  ++GKts l +++ d+   ++ +tig +    +             kkv+++++D++Gq+++r+l ++y+++ +++i+++ds++ e++ke  
  EFC39591.1  25 KILFLGLDAAGKTSALYKIQLDEN-VSTIPTIGFNAEVIQ------------YKKVTFRVFDIGGQDKIRKLWRHYYQSTNAIIFIVDSNDTERFKEaa 110
                 99***************9987665.577899999874322............35799******************************977665555500 PP

                 .HHHHHHHH..CSSS-EEEEEE-TT CS
         Roc  98 .Wlkelkkv..agkspvilvgnkiD 119
                   l+e+ +    +++++++ +nk D
  EFC39591.1 111 eTLREVMQDdlLKDAKLLVWANKQD 135
                 0555554332244567778889988 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.2   0.1     2e-12   3.9e-09       1     136 [.      25     149 ..      25     164 .. 0.83

  Alignments for each domain:
  == domain 1  score: 36.2 bits;  conditional E-value: 2e-12
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletl 98 
                 k+L++G   +GKts    ++ +++  + ++   ti  + + +  ++++t+ ++D+gGq+++ +        + +++ +++i+++D++++e ++e+ etl
  EFC39591.1  25 KILFLGLDAAGKTSA---LY-KIQLDENVSTIPTIGFNAEVI-QYKKVTFRVFDIGGQDKIRKLW-----RHYYQSTNAIIFIVDSNDTErFKEAAETL 113
                 89***********95...44.5566666777799*9999988.6999************998775.....88999************9977******** PP

   Gtr1_RagA  99 keilealrqyspeakvfvlihKmDliqedereeifeer 136
                 +e+++   +  ++ak+ v  +K Dl +  + ++++++ 
  EFC39591.1 114 REVMQD--DLLKDAKLLVWANKQDLPRAANVKDMVNTL 149
                 ***995..7889************98876666665554 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   4.2e-07   0.00084       1     114 []      25     133 ..      25     133 .. 0.66

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 4.2e-07
                 EEEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.TTCSHHHHHHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflaleeadlillvvdas.eeklkpldeele 98 
                 +++++G   +GK++ + ++      vs +p  T+  n + +++k+  +++ D+ G  +  + + +l +++ +  ++++i+++vd++ +e +k+  e+l 
  EFC39591.1  25 KILFLGLDAAGKTSALYKIQL-DENVSTIP--TIGFNAEVIQYKKVTFRVFDIGG-QD--KIR-KLWRHYYQ--STNAIIFIVDSNdTERFKEAAETLR 114
                 58899*********9999954.34555555..444444444444677********.43..222.34444443..479*******777556777778887 PP

                 HHHHH...TTSEEEEEEES CS
    MMR_HSR1  99 ellee...akkplilvlnk 114
                 e++++   ++ +l++ +nk
  EFC39591.1 115 EVMQDdllKDAKLLVWANK 133
                 7776566556666666665 PP

>> DUF1015  Protein of unknown function (DUF1015)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   4.2e-05     0.083      14      99 ..      62     141 ..      52     162 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.2e-05
     DUF1015  14 v.laevasppYDviseeearelakknpysflrlilpeadledeedeedryekaaetleewleegvlvqdekpalyvyeqtfedggrv 99 
                 +  ++v+ + +D+  +++ r+l ++  +s+  +i+   d   ++d+e r+++aaetl+e++++++l +d+k  ++  +q+  +    
  EFC39591.1  62 IqYKKVTFRVFDIGGQDKIRKLWRHYYQSTNAIIFIV-D---SNDTE-RFKEAAETLREVMQDDLL-KDAKLLVWANKQDLPR-AAN 141
                 4678899999999999999999999999999999953.2...33434.******************.8887766666666654.555 PP

>> Vmethyltransf  Viral methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   8.3e-05      0.17      51     106 ..      68     123 ..      59     151 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 8.3e-05
  Vmethyltransf  51 pstildiggn.klshlkrgrsnvqhhdcnplldprDvaRyterelslesalssledk 106
                     + + digg+ k+++l r+  +++++ +  ++d+ D +R  e+++ l+++++++  k
     EFC39591.1  68 TFRVFDIGGQdKIRKLWRHY-YQSTNAIIFIVDSNDTERFKEAAETLREVMQDDLLK 123
                    677899987559**999884.435566**********************99988776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (182 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       778  (0.0433934); expected 358.6 (0.02)
Passed bias filter:                      574  (0.0320152); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.56u 0.34s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 1064.78
//
Query:       EFC39592.1  [L=218]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.5e-18   64.7   0.1    2.8e-09   36.7   0.0    2.2  2  adh_short     short chain dehydrogenase
      1e-07   31.8   0.0    0.00014   21.5   0.0    2.1  2  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
     0.0083   16.1   0.1      0.012   15.5   0.1    1.2  1  KR            KR domain


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   0.1   4.7e-10   2.8e-06       2      63 ..      16      71 ..      15      75 .. 0.83
   2 !   36.7   0.0   4.8e-13   2.8e-09     143     192 ..      73     122 ..      70     125 .. 0.91

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 4.7e-10
                EEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHHH CS
   adh_short  2 vvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkeegakalaiqvDvtdree 63
                v l++G s G+Gr+++k ++ +G kv++++rs +k+    + lke+   a+++q+Dvt+ ++
  EFC39592.1 16 VWLIVGTSTGFGREFVKSVLHRGEKVIATARSLDKI----QDLKEL--XAHTMQLDVTSDQA 71
                669*******************************99....444443..489*******5544 PP

  == domain 2  score: 36.7 bits;  conditional E-value: 4.8e-13
                 -TTBHHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHHHHHHCT CS
   adh_short 143 vagvaaYsAsKaavagltrslakelaptgirvnavaPGlvdTdmakelre 192
                 v+++  Y+A+K+av++++++l++e+a  gi+v++v PG+++Td+  +++ 
  EFC39592.1  73 VKVGGLYCATKFAVEAISEALKDEVAHLGIKVVVVEPGYFRTDLLSSSNM 122
                 567889*************************************9988765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.3   0.0   0.00013      0.76       1      55 [.      21      71 ..      21      76 .. 0.88
   2 !   21.5   0.0   2.4e-08   0.00014     136     200 ..      74     137 ..      68     146 .. 0.81

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00013
                  TTTTSHHHHHHHHHHHTT-EEEEEESSGGHHHHHHHHHHHTTSEEEE--TTSHHH CS
  adh_short_C2  1 GaasgIGraiAkalaeeGaevvltdlneeakkrveelaeelgaevlecDVtdeeq 55
                  G   g Gr+ +k++  +G +v++t ++ ++   +++l+e l a+ +++DVt++++
    EFC39592.1 21 GTSTGFGREFVKSVLHRGEKVIATARSLDK---IQDLKE-LXAHTMQLDVTSDQA 71
                  66789********************99998...888865.8899*******9986 PP

  == domain 2  score: 21.5 bits;  conditional E-value: 2.4e-08
                   TTTTHHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTGGGGSTTHHHHHHHHHHHSTTSS CS
  adh_short_C2 136 pnynaygaaKaalealtrylAvelgpkgiRvNavspgpikTlaasgikgfdelleelearaplgr 200
                   +    y+a+K a+ea++ +l  e+++ gi+v +v pg+ +T++ s+ + +++ ++ + +  p+ +
    EFC39592.1  74 KVGGLYCATKFAVEAISEALKDEVAHLGIKVVVVEPGYFRTDLLSSSN-MKDAKKTISDYEPIYK 137
                   55569**************************************88765.6666666666666655 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1     2e-06     0.012       3     108 ..      17     128 ..      15     131 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 2e-06
                 EEEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-.....EEEE----TT-HHHHHHHHHHHHHHS..S---EEEE------- CS
          KR   3 ylitGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealga.....evevvaaDvsdkdavealleeikaee..ppikGvihaAgvlrd 94 
                  li+G   g+G+e+++  +++g++ ++ ++Rs  + +d k+l a+  +l++     +v+v  +  + k avea+ e++k+e     ik v+   g +r+
  EFC39592.1  17 WLIVGTSTGFGREFVKSVLHRGEK-VIATARSLDKIQDLKELXAHTMQLDVtsdqaSVKVGGLYCATKFAVEAISEALKDEVahLGIKVVVVEPGYFRT 114
                 79*******************975.77899996444444443333333333222227788788888888999999999888766678899999999999 PP

                 --TTT--HHHHHHH CS
          KR  95 klleemtaedleqv 108
                 +ll++ +++d ++ 
  EFC39592.1 115 DLLSSSNMKDAKKT 128
                 99888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       533  (0.0297284); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.54
# Mc/sec: 1212.38
//
Query:       EFC39593.1  [L=665]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.2e-68  228.2   0.2    7.6e-68  227.4   0.2    1.4  1  Arf       ADP-ribosylation factor family
    1.8e-12   47.0   0.0    1.8e-12   47.0   0.0    1.6  1  SRPRB     Signal recognition particle receptor beta subunit
      3e-12   46.4   0.5    8.9e-12   44.9   0.0    2.0  2  Ras       Ras family
    2.3e-11   43.9   1.7    2.7e-11   43.7   0.0    2.1  2  Roc       Ras of Complex, Roc, domain of DAPkinase
    2.8e-09   36.6   7.1    9.8e-08   31.5   0.0    3.1  3  G-alpha   G-protein alpha subunit
    0.00015   22.0   0.1    0.00045   20.4   0.1    1.9  1  BTB       BTB/POZ domain
    0.00031   20.8   2.0    0.00045   20.3   0.0    2.2  2  MMR_HSR1  50S ribosome-binding GTPase
  ------ inclusion threshold ------
       0.13   12.8   2.9       0.34   11.4   2.9    1.7  1  DUF3391   Domain of unknown function (DUF3391)
       0.28   10.7   0.0       0.28   10.7   0.0    2.1  3  GTP_EFTU  Elongation factor Tu GTP binding domain
        5.6    8.2   0.0        5.6    8.2   0.0    3.4  1  DUF2971   Protein of unknown function (DUF2971)
        7.3    6.3   7.4         15    5.3   7.4    1.5  1  DUF3464   Photosynthesis affected mutant 68


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  227.4   0.2   4.6e-71   7.6e-68       9     174 ..     477     641 ..     472     642 .. 0.97

  Alignments for each domain:
  == domain 1  score: 227.4 bits;  conditional E-value: 4.6e-71
                 TT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHH CS
         Arf   9 klkkkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLkal 107
                    +kelr l lG+D++GKtT+l+klkl+e+vtt+PTigfnve++ +kn k+t+wDvGG  klR lW++Y+++t++v+fvvDs+dr+Rleea ++L++l
  EFC39593.1 477 SHLHKELRFLNLGIDASGKTTLLYKLKLDEVVTTIPTIGFNVETVDYKNAKITMWDVGGAYKLRALWRHYYQNTNGVVFVVDSNDRDRLEEAADDLHKL 575
                 55689********************************************************************************************** PP

                 CTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 108 leeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlses 174
                  +e+elk++++l+laNKqDlp+a+s +e++++++l++l+ ++k+ iq+c+a++gegl+eglew +es
  EFC39593.1 576 AKEDELKDCPILILANKQDLPNAMSVAEIADKMKLTSLS-QKKWFIQACCALTGEGLYEGLEWAVES 641
                 ***************************************.***********************9876 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.0   0.0   1.1e-15   1.8e-12       5     136 ..     484     607 ..     480     617 .. 0.88

  Alignments for each domain:
  == domain 1  score: 47.0 bits;  conditional E-value: 1.1e-15
                 EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHHHHH CS
       SRPRB   5 avllvGlsdsGKTslftrLttdsvkktvtSq.essaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEllyei 102
                 ++l +G+  sGKT+l+ +L  d+v +t   +  +  + ++   k+ k+t+ D+ G  klr     +  + ++  g+vfvvDS  d  +++e A+ l ++
  EFC39593.1 484 RFLNLGIDASGKTTLLYKLKLDEVVTTIPTIgFNVETVDY---KNAKITMWDVGGAYKLRALW-RH--YYQNTNGVVFVVDSN-DRDRLEEAADDLHKL 575
                 68889**************************899999999...9****************855.44..578899*******97.7788*********** PP

                 HHHHHHHTT---EEEEEE-TTSTT---HHHHHHH CS
       SRPRB 103 lliteklkdavdiliACnKqelflakspklikda 136
                 + + e   +  +ili  nKq+l  a s   i d+
  EFC39593.1 576 AKEDE--LKDCPILILANKQDLPNAMSVAEIADK 607
                 99999..445789999******999998888776 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.2       1.2     2e+03      69     102 ..      53      86 ..      47     107 .. 0.64
   2 !   44.9   0.0   5.5e-15   8.9e-12       4     154 ..     487     636 ..     484     643 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.2
                 HTTESEEEEEEETTBHHHHHTHHHHHHHHHHHST CS
         Ras  69 yrdaegillvyditsresfenvkkwveeikrvae 102
                 +r+++  ++ y i ++e+ +++++  +++++ +e
  EFC39593.1  53 IRKVQNSMIYYLIRDEETKSDAADQKQQVETETE 86 
                 5556666666666666666655555555555444 PP

  == domain 2  score: 44.9 bits;  conditional E-value: 5.5e-15
                 EEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHST CS
         Ras   4 lvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrvae 102
                  +G  a GKt+ll++   d+  ++ ++Tig++    +  vd k++k+++wD  G  + ++l + yy++++g++ v d ++r+ +e++++ ++++ +  e
  EFC39593.1 487 NLGIDASGKTTLLYKLKLDEVVTT-IPTIGFNVE--T--VDYKNAKITMWDVGGAYKLRALWRHYYQNTNGVVFVVDSNDRDRLEEAADDLHKLAKEDE 580
                 589999*************98875.9***87654..3..5667788899***************************************88888888888 PP

                 .TTSEEEEEEETTTGGGG-SS-HHHHH.HHH..HHHTSEEEEEBTTTTCTHHHHHH CS
         Ras 103 .envpivLvGnKvDleekravsteege.ela..kelglkfletSAktnenveeafe 154
                  +++pi++++nK Dl +   v +   + +l   ++++     + A t e++ e +e
  EFC39593.1 581 lKDCPILILANKQDLPNAMSVAEIADKmKLTslSQKKWFIQACCALTGEGLYEGLE 636
                 899*************9777654322202221122223333466666666666555 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.5       8.4   1.4e+04      28      42 ..      75      89 ..      59     104 .. 0.45
   2 !   43.7   0.0   1.7e-14   2.7e-11       4     119 ..     487     594 ..     484     595 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 8.4
                EETTTTEEEEEEECG CS
         Roc 28 ekstigvdfltkevt 42
                 ++  +v++ t++++
  EFC39593.1 75 ADQKQQVETETEKTN 89
                333333333333322 PP

  == domain 2  score: 43.7 bits;  conditional E-value: 1.7e-14
                 EESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHHHHHHH CS
         Roc   4 lvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssenlkeWlkel 102
                  +G  ++GKt+ll ++  d++  ++ +tig ++ t ++            k+ k+ +WD++G  + r+l ++y+++ + +++v+ds++ ++l+e  ++l
  EFC39593.1 487 NLGIDASGKTTLLYKLKLDEVV-TTIPTIGFNVETVDY------------KNAKITMWDVGGAYKLRALWRHYYQNTNGVVFVVDSNDRDRLEEAADDL 572
                 589999***********99996.568*****9966433............346799*****************************99999888877777 PP

                 HHHCS.....SS-EEEEEE-TT CS
         Roc 103 kkvag.....kspvilvgnkiD 119
                 +k a+     ++p+++++nk D
  EFC39593.1 573 HKLAKedelkDCPILILANKQD 594
                 777652222256999*****99 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   1.4       0.5   8.1e+02      89     133 ..      60     111 ..       8     223 .. 0.63
   2 !    8.1   0.1   0.00079       1.3      18      45 ..     476     504 ..     468     506 .. 0.81
   3 !   31.5   0.0     6e-11   9.8e-08     180     281 ..     506     595 ..     500     599 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.5
                 .......HHHC-SS-SCCCS-HCHHHH..................HHCCHHC-HCHHHH CS
     G-alpha  89 f......elqelkerldplkkveasliaklssateee........qeiefnpraevged 133
                 +      ++++ ++++d+ ++ve +  + ++  +++e        +      ++++ +d
  EFC39593.1  60 MiyylirDEETKSDAADQKQQVETETEK-TNDENNQEkkeenkekK------EEKIPND 111
                 0444443333333444444444444333.22222222222222222......2222222 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00079
                 XXE...EEEEEEEESTTSSHHHHHHHHHH CS
     G-alpha  18 rkk.krevkllllGqseSGKsTilkqlkl 45 
                  +   +e+++l lG + SGK+T+l +lkl
  EFC39593.1 476 ISHlHKELRFLNLGIDASGKTTLLYKLKL 504
                 44456799****************99985 PP

  == domain 3  score: 31.5 bits;  conditional E-value: 6e-11
                 HHHCS-----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE- CS
     G-alpha 180 DilkarlktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnK 278
                  ++++ ++t+G++  +++++ + +++++dvgG+ + r+ W +++++++ ++F+v           ++   rlee+ +  +++ ++ +lk++pi+++ nK
  EFC39593.1 506 EVVTT-IPTIGFNVETVDYK-NAKITMWDVGGAYKLRALWRHYYQNTNGVVFVVD----------SNDRDRLEEAADDLHKLAKEDELKDCPILILANK 592
                 44444.79***********9.********************************98..........55569***************************** PP

                 HHH CS
     G-alpha 279 lDi 281
                  D+
  EFC39593.1 593 QDL 595
                 *97 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.1   2.8e-07   0.00045       9     108 ..     138     257 ..     130     260 .. 0.81

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 2.8e-07
                 TTS-EEEEETT.TEEEEE-HHHHHHH-HHHHHHHTST........TTTTCCCE.....EEEETTSGHHHHHHHHHHHHHSEEEC-............CG CS
         BTB   9 elcDvtlvvgd.gkefkahkavLaarSpyFkalftsk........eieessvs.....eielddvepeafealLefiYtgeleit............se 81 
                 el+  t+ + d +k++ + +  L   S++F+ +++s+        +      +       e ++ + e f+  +efi+ g+l ++            ++
  EFC39593.1 138 ELVYFTIHIPDiKKKLLVSRELLLLESKVFEGMLNSEmlesksneM------TlqkeqAQEGEKSSCEYFDLAMEFIHVGKLGVSktsfnenvsniiEW 230
                 5555677777778999999******************665544421......13333334457778889****************************** PP

                 GGHHHHHHHHHHHT-HHHHHHHHHHHH CS
         BTB  82 enleelLaaadllqiprlkkaceeflk 108
                 ++l  lL++ad +qi++l +a+++ + 
  EFC39593.1 231 KDLLGLLRIADEYQIESLSRAISRVVN 257
                 ******************999987765 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.5       2.5   4.2e+03      69      99 ..      52      83 ..      38     108 .. 0.48
   2 !   20.3   0.0   2.8e-07   0.00045       6     114 .]     489     592 ..     485     592 .. 0.74

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 2.5
                HHHHHHCTSEEEEEEETT......TTCSHHHHHHHHH CS
    MMR_HSR1 69 aflaleeadlillvvdas......eeklkpldeelee 99
                a++++++ ++i ++++ +           ++++++e 
  EFC39593.1 52 AIRKVQN-SMIYYLIRDEetksdaA----DQKQQVET 83
                4444333.66666665233432220....22222222 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 2.8e-07
                 ESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.TTCSHHHHHHHHHHHHH CS
    MMR_HSR1   6 GrpNvGKStLinaltgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflaleeadlillvvdas.eeklkpldeeleellee 103
                 G   +GK+tL+ +l  ++  v+ +p  T+  n ++v++k+ +i+++D+ G ++     + l +++ +  +++ +++vvd++ ++ l++   +l++l +e
  EFC39593.1 489 GIDASGKTTLLYKLKLDE-VVTTIP--TIGFNVETVDYKNAKITMWDVGGAYK----LRALWRHYYQ--NTNGVVFVVDSNdRDRLEEAADDLHKLAKE 578
                 555689999999996543.345555..77778888888899*********887....4466666665..578*******77644677777788887776 PP

                 ...TTSEEEEEEES CS
    MMR_HSR1 104 ...akkplilvlnk 114
                    ++ p+++++nk
  EFC39593.1 579 delKDCPILILANK 592
                 77777788888887 PP

>> DUF3391  Domain of unknown function (DUF3391)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   2.9   0.00021      0.34      36     100 ..      49     107 ..      27     143 .. 0.70

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00021
     DUF3391  36 seadierLrasgiqeVwidtdksdeeelagldvpaaeaaeeakaaeesaeleeekqerperleae 100
                 +e+ i+++++s i +++ d + + ++  ++++v+ +++++++++++e++e+ +ek+      e++
  EFC39593.1  49 NEEAIRKVQNSMIYYLIRDEETKSDAADQKQQVETETEKTNDENNQEKKEENKEKK------EEK 107
                 7899*************999995555555555555555444444444444444433......333 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.3   2.1         7   1.1e+04      38     157 ..      84      97 ..      65     120 .. 0.49
   2 ?   -2.6   0.0         2   3.3e+03      14      23 ..     493     502 ..     485     510 .. 0.82
   3 ?   10.7   0.0   0.00017      0.28      60     149 ..     518     611 ..     504     644 .. 0.77

  Alignments for each domain:
  == domain 1  score: -4.3 bits;  conditional E-value: 7
                 HHHSTHCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTBSTHHHHHHHHHHHHTTTEEEEEEESCGSTH CS
    GTP_EFTU  38 eeervlDtlkeErergiTiksaaisleketkkylinliDtPGHvdFskevirglrvlDgavlvvdaveGvepqteevlrlalkegvpiivfiNKmDrlk 136
                 e+e++ D +++E+                                                                                      
  EFC39593.1  84 ETEKTNDENNQEK-------------------------------------------------------------------------------------- 96 
                 1222223222222...................................................................................... PP

                 HHHHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU 137 aelkeiveevkqklsrkeekl 157
                                      
  EFC39593.1  97 --------------------K 97 
                 ....................2 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2
                 SSHHHHHHHH CS
    GTP_EFTU  14 hGKtTLtdrL 23 
                 +GKtTL+ +L
  EFC39593.1 493 SGKTTLLYKL 502
                 6*****9877 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.00017
                 EEEEETTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB..STHHHHHHHHHHHHTTTE...EEEEEESCGST.HHHHHHHHHHHHHH CS
    GTP_EFTU  60 aisleketkkylinliDtPGHvdFskevirglrvlDgavlvvdaveG..vepqteevlrlalkegvp...iivfiNKmDrl.kaelkeiveevkqk 149
                 + ++  ++k+ +i++ D  G  +      + ++ ++g+v+vvd+++    e+    + +la++ +++   i ++ NK D +   ++ ei++++k +
  EFC39593.1 518 VETV--DYKNAKITMWDVGGAYKLRALWRHYYQNTNGVVFVVDSNDRdrLEEAADDLHKLAKEDELKdcpILILANKQDLPnAMSVAEIADKMKLT 611
                 3333..5999999999999999999999999*************9766699999999999999999888688889*****9766777887777733 PP

>> DUF2971  Protein of unknown function (DUF2971)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.0    0.0034       5.6       1      25 [.     542     566 ..     542     608 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0034
     DUF2971   1 mWrhYgdnhkGvclgfdkeklkedt 25 
                 +WrhY +n +Gv+++ d+++ ++  
  EFC39593.1 542 LWRHYYQNTNGVVFVVDSNDRDRLE 566
                 6****************99755444 PP

>> DUF3464  Photosynthesis affected mutant 68
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   7.4    0.0091        15      14      55 ..      70     112 ..      44     115 .. 0.62

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0091
     DUF3464  14 rkkkpkkkkkskkakkeek.ekakeeekkdkeekeeaaiPevV 55 
                 +k+ ++++k++ ++++e++ +++++e+k++++ek+e++iP+++
  EFC39593.1  70 TKSDAADQKQQVETETEKTnDENNQEKKEENKEKKEEKIPNDL 112
                 22233333333333333333566666677777777788**875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2680  (0.149478); expected 358.6 (0.02)
Passed bias filter:                     1026  (0.0572257); expected 358.6 (0.02)
Passed Vit filter:                       168  (0.00937029); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.94u 0.36s 00:00:01.29 Elapsed: 00:00:00.54
# Mc/sec: 3731.71
//
Query:       EFC39594.1  [L=789]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.2e-57  195.7   0.0      7e-39  134.1   0.0    3.1  3  A_deaminase  Adenosine/AMP deaminase


Domain annotation for each model (and alignments):
>> A_deaminase  Adenosine/AMP deaminase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.6   0.0   3.6e-13   6.4e-09       2      68 ..     110     175 ..     109     185 .. 0.93
   2 !  134.1   0.0   3.9e-43     7e-39     152     326 ..     182     356 ..     176     358 .. 0.97
   3 !   23.1   0.0   2.2e-09     4e-05      83     273 ..     508     700 ..     490     749 .. 0.83

  Alignments for each domain:
  == domain 1  score: 35.6 bits;  conditional E-value: 3.6e-13
                  S-EEEEEEECCCSS-HHHHHHHHHHHCHT..SS-SCCCCCCCCHCHCCHHHHCCHCCCHHCCCHHHT CS
  A_deaminase   2 lpKvdlHvHldgclnpktllrlakkkgikeldekvveedeklltlqekfesLkeflydlsvdvlvlh 68 
                  lpK++lH Hldg+++ +t+++lak++g++ l+  +vee+ kl+   ++ +sL e+l+ +++ ++v++
   EFC39594.1 110 LPKAELHRHLDGSVRVETIIELAKEQGVD-LPSFDVEELRKLVSVTNDCTSLVEYLRGFDISLSVMQ 175
                  8**************************99.************************************9 PP

  == domain 2  score: 134.1 bits;  conditional E-value: 3.9e-43
                  HHHHHCCCCCCCCCCCCC-TTSTTGGGHHHHHCCCCHTT-EEEEEESSSS-CHHHHHHHHCS--SCECE-GGGGGSHHHHHHHHHCT-EEEE-HHHHC CS
  A_deaminase 152 elasyyrdytvvnldllndekiepaslflklraeagkstllltpHaGEagglehvveAllllkaerigHGvrlrkdpvLqyllalaqiplevcPlSNv 249
                  + a +yrd++v ++dl++ e+++ ++++ ++++    + l  t H+GEa g e++++ ++ ++a+rigHG++l++ p+L +  a+++ip+e+c +SN 
   EFC39594.1 182 QIAWRYRDRGVCAFDLAGPENGFSSKNHASAFELVHRKMLNCTLHSGEASGWESIQDSIRYCGANRIGHGTHLKENPDLTQYVANHRIPIEICITSNL 279
                  66789********************************************************************************************* PP

                  CCSST-TTTT-CHHHHHHTT-EEEE--BSCCCCT-SHHHHHHHHHHHHT--HHHHHHHHHHHHHCSSS-HHHHHHHC CS
  A_deaminase 250 algafleyaenPlkeflerglnvslntDDPlqfgttLieeYaiaaqvfklseedlaelarNsvkqsflsadekkkll 326
                  +++a ++ +e+P++ef++ g+ +   tD+  ++++tL+eeY  ++++f+++ +++ +l   + +++fl+   k++l 
   EFC39594.1 280 QTKAIQKFEEHPVREFFDYGIVLVPCTDNTTVSNVTLSEEYLLIQNQFGFDVKEIVKLIDYGFRSAFLDLSIKNRLR 356
                  *************************************************************************9985 PP

  == domain 3  score: 23.1 bits;  conditional E-value: 2.2e-09
                  CCCHCTTCCCCCCCCSHHHHHHH-GCSTCCHHHHCCCCCCCCCCHCCT-EEEEEECCETT.TCCGHCCCHHHHHHCCCCCCCCCCCC..C-TTSTTGG CS
  A_deaminase  83 kdlakdfvkylevifsPlfeatagpqlpelevvlkvvdgfdsvedeskvkerlilvksrk.peewseeinelasyyrdytvvnldll..ndekiepas 177
                  +++a++ v yle+++ P++++++g  l+ +ev++ +v  +++  +   +++ l++    +     + ++  l +   ++ +v+++    ndek+    
   EFC39594.1 508 EKAAAEHVFYLELQVRPTMHTKRG--LSAQEVLDVMVVTINECSKRYNIQVGLVVYGDFTsDGLDQLKELSLLTIRNKKNLVGFGFFgyNDEKGAILP 603
                  678999999***************..**********************99988776555534444444555555555568999998611566666666 PP

                  GHHHHHCCCCHTT-EEEEEESSSS-CHHHHHHHHCS--SCECE-GGGGGSHHHHHHHHHCT-EEEE-HHH..HCCCSST-TTTT-CHHHHHHTT-EEE CS
  A_deaminase 178 lflklraeagkstllltpHaGEagglehvveAllllkaerigHGvrlrkdpvLqyllalaqiplevcPlS..NvalgafleyaenPlkeflerglnvs 273
                  +   +++   ++++ +   aG   +  +v  A+ +++a+r++   ++  +p ++  l ++ +p+e++ +    + ++ ++e a   ++ fl+rg++v+
   EFC39594.1 604 ELIPVFNMLKNHQINVCCSAGFYNP-LSVIPAIHDVGASRLSGCFSIHSSPSVMSYLCDNGVPIEISMTDtlKNLTKEVNEFAGSAVRLFLDRGIKVA 700
                  699******************7655.5777899999*****************************9987622578999*****************997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (789 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       494  (0.0275531); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 4592.78
//
Query:       EFC39595.1  [L=280]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.4e-05   23.6   0.0    0.00011   22.9   0.0    1.3  1  Methyltransf_25  Methyltransferase domain
  ------ inclusion threshold ------
      0.051   13.0   0.3      0.075   12.4   0.3    1.2  1  Spermine_synth   Spermine/spermidine synthase domain


Domain annotation for each model (and alignments):
>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.0   1.2e-08   0.00011       4      94 ..     120     211 ..     118     213 .. 0.86

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 1.2e-08
                      ET-TTSHHHHHHHCTS....TSSEEEEEESSHHHHHHHHHHHHHTTTTEEEEESBCCGBSSSTTTEEEEEEEST.GGGSSHHHHHHHHHHHHHH CS
  Methyltransf_25   4 lGcGtGrltlalakrl....gkakvtgvDiseemleaareraeeeglnvefvqgdaedlpfedgsfDlvvssga.lhhlsdedlekalkeiarv 92 
                      +G G G ++++l k      + ++v  ++++e+ +++++e a ++  ++ef+ ++  d++  + s D+v+++++ l hl+++ +++++++++++
       EFC39595.1 120 VGVGLGAVLKRLEKLNhlmeQFENVKVLEPNETIIRKCKEIATSS--KIEFLSCEYLDIS--KCSADIVMLQMEyLKHLDNKSIAQLIQNCRNI 209
                      79999999999988864454389*******************655..8999988887776..668**************************998 PP

                      EE CS
  Methyltransf_25  93 Lk 94 
                       k
       EFC39595.1 210 AK 211
                      77 PP

>> Spermine_synth  Spermine/spermidine synthase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.3   8.4e-06     0.075       8      91 ..     103     196 ..      97     222 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 8.4e-06
                     HHHHHHCCSSST-EEEEESSTTSHHHHHHTTSTT-....SEEEEEES-HHHHHHHHHHSHHHHTT.....CGGCTTEEE.EESTCHHHHCTCSS CS
  Spermine_synth   8 iahvplmlhknpkevLiiGGgDGgvlrevvkhntv....ekitlvdiDqkvidfskkflpslais.....afndarvkl.vlgdgfkflkayek 91 
                     ++ v  + ++++k  +i+G g G vl+++ k+n +    e++ + +  + +i  +k++  s +i+      ++ +++   ++++ +++lk + +
      EFC39595.1 103 LGQVIESCKSEKKSLIIVGVGLGAVLKRLEKLNHLmeqfENVKVLEPNETIIRKCKEIATSSKIEflsceYLDISKCSAdIVMLQMEYLKHLDN 196
                     5555556666777778888889***********878999*******************999999977775556677777777777777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (280 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       796  (0.0443973); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1727.48
//
Query:       EFC39596.1  [L=150]
Description: cofilin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.6e-23   82.1   0.7    2.9e-23   81.9   0.7    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
     0.0029   17.6   0.5     0.0037   17.3   0.5    1.2  1  SelP_C       Selenoprotein P, C terminal region


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.9   0.7   3.3e-27   2.9e-23       2     121 .]      12     144 ..      11     144 .. 0.94

  Alignments for each domain:
  == domain 1  score: 81.9 bits;  conditional E-value: 3.3e-27
                  HHHHHHHCTTT.....SSEEEEEEECTTTEEEEEESS-...HHHHHHHHHHTTT-EEEEEEEEEECCS........ECCEEEEEEEEE--TTS-HHHH CS
  Cofilin_ADF   2 keafkelksgk....ktkyilfkidddkeeivveeege...tyeelreelpeseprYavydveyehdd........eskrsklvfIswvPdsapikqk 84 
                  +++++e+++gk    ++k++++k+++   +i++++e +   +++el+++lp ++ r+++y++++e ++        e+ r+k++f++w+P+++++k+k
   EFC39596.1  12 IKTYEEMRMGKgsnkDKKFLVLKMQES--SIQIDQELTqlsSLDELTSNLPPKNSRFICYHLSFEMPSqnetcqirEGIRTKMMFLTWCPNETNVKEK 107
                  689**********9999*******976..69999866677899***********************99999999999999***********99***** PP

                  HHHHHHHHHHHHHCTTSEEEEEE-CGGCCSHHHHHHH CS
  Cofilin_ADF  85 mlyasskdalkkelkgisveieatdldelteeelkek 121
                    +a++ +++k++l+g+s +i++++++e++e+++ ek
   EFC39596.1 108 FQVAATVKTVKQKLNGLSATIHCSTKSEIDEKSMIEK 144
                  ********************************99886 PP

>> SelP_C  Selenoprotein P, C terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.5   4.1e-07    0.0037      32     124 ..      40     135 ..      12     146 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 4.1e-07
      SelP_C  32 rcinqllcklsk....dseaalssccchcrhlifektgsaitcqcaenlpslcsc.qgllaeekviescqcrlppaacqisqqlnpteasakcscknk 124
                   i+q l +ls      s++ ++     c hl fe      tcq +e + +          e +v e  q+     ++  +q+ln + a+ +cs k +
  EFC39596.1  40 IQIDQELTQLSSldelTSNLPPKNSRFICYHLSFEMPSQNETCQIREGIRTKMMFlTWCPNETNVKEKFQVAATVKTV--KQKLNGLSATIHCSTKSE 135
                 4577777777752222466678899999*******************99876554045567889***99987665554..6************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       854  (0.0476323); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.36u 0.26s 00:00:00.62 Elapsed: 00:00:00.41
# Mc/sec: 1091.98
//
Query:       EFC39597.1  [L=1038]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.08   13.3   0.8       0.26   11.6   0.8    1.9  1  HBS1_N    HBS1 N-terminus


Domain annotation for each model (and alignments):
>> HBS1_N  HBS1 N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.8   1.4e-05      0.26      44      76 ..     607     639 ..     594     641 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.4e-05
      HBS1_N  44 tvtekqikeAlwkyyyDvekaldyllnkfkkkk 76 
                 + +++q+ + l +++ +v+ + dy++++++kk+
  EFC39597.1 607 EYSDHQLAQVLAEHENNVQSSADYIMQQYVKKT 639
                 3599***************************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1038 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1160  (0.0646996); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.87u 0.30s 00:00:01.17 Elapsed: 00:00:00.49
# Mc/sec: 6308.13
//
Query:       EFC39598.1  [L=130]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       564  (0.0314574); expected 358.6 (0.02)
Passed bias filter:                      416  (0.0232026); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.32s 00:00:00.84 Elapsed: 00:00:00.53
# Mc/sec: 742.74
//
Query:       EFC39599.1  [L=430]
Description: fatty acid desaturase domain protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (430 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       642  (0.0358079); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.49
# Mc/sec: 2655.73
//
Query:       EFC39600.1  [L=250]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (250 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       649  (0.0361983); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.34s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 1405.80
//
Query:       EFC39601.1  [L=198]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.6e-10   40.0  10.6      6e-10   39.3  10.6    1.4  1  zf-RING_2      Ring finger domain
    1.3e-07   31.3   9.8    2.2e-07   30.6   9.8    1.4  1  zf-C3HC4_2     Zinc finger, C3HC4 type (RING finger)
    1.1e-06   28.5   4.9    1.1e-06   28.5   4.9    2.1  2  zf-RING_UBOX   RING-type zinc-finger
    3.3e-06   27.3  11.1    9.1e-06   25.9  11.1    1.8  1  zf-rbx1        RING-H2 zinc finger domain
    4.8e-06   26.3  10.4    7.9e-06   25.6  10.4    1.4  1  zf-C3HC4       Zinc finger, C3HC4 type (RING finger)
    1.2e-05   25.0   6.8    1.8e-05   24.5   6.8    1.3  1  zf-C3HC4_3     Zinc finger, C3HC4 type (RING finger)
    1.9e-05   24.3   6.4    1.9e-05   24.3   6.4    2.3  2  zf-RING_11     RING-like zinc finger
    0.00076   19.5   2.2     0.0016   18.4   2.2    1.6  1  zf-ANAPC11     Anaphase-promoting complex subunit 11 RING-H2 
     0.0073   16.2   9.6      0.012   15.5   9.6    1.4  1  zf-RING_5      zinc-RING finger domain
  ------ inclusion threshold ------
      0.038   13.6   5.4      0.066   12.9   5.4    1.3  1  Zn_ribbon_17   Zinc-ribbon, C4HC2 type
       0.25   11.2   8.9        0.9    9.4   9.1    1.7  2  zf-RING_4      RING/Ubox like zinc-binding domain
        0.3   11.0  10.4         20    5.2  11.9    2.3  2  Prok-RING_4    Prokaryotic RING finger family 4
       0.33   11.1   4.9        1.1    9.4   4.9    1.8  2  Zf_RING        KIAA1045 RING finger
       0.66   10.2   8.5        7.6    6.8   8.7    2.2  2  FANCL_C        FANCL C-terminal domain
       0.86    9.5   8.0        1.7    8.6   8.0    1.5  1  PHD            PHD-finger
       0.92    9.7  10.3        1.9    8.7  10.3    1.6  1  zf-C3HC4_4     zinc finger of C3HC4-type, RING
       0.95    9.8   7.4        2.5    8.5   7.4    1.8  1  zf-RING-like   RING-like domain
          2    8.6   9.5          4    7.6   9.5    1.5  1  RINGv          RING-variant domain
        2.2    8.2   7.1        1.3    8.9   0.2    2.9  3  Rad50_zn_hook  Rad50 zinc hook motif


Domain annotation for each model (and alignments):
>> zf-RING_2  Ring finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.3  10.6   6.4e-13     6e-10       2      43 ..      97     138 ..      96     139 .. 0.87

  Alignments for each domain:
  == domain 1  score: 39.3 bits;  conditional E-value: 6.4e-13
   zf-RING_2   2 eCpICleelssadsvlllpCgHvfhreClerwlrssstCPlC 43 
                  CpICle +++++  +l++C+H fh++C e+w ++s++CP+C
  EFC39601.1  97 ICPICLELYTRDNPQILCKCSHGFHFQCSEEWKQRSNECPVC 138
                 6*****8887766655669*********************** PP

>> zf-C3HC4_2  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.6   9.8   2.4e-10   2.2e-07       2      40 .]      98     138 ..      97     138 .. 0.93

  Alignments for each domain:
  == domain 1  score: 30.6 bits;  conditional E-value: 2.4e-10
  zf-C3HC4_2   2 CpiCldmlk..dpsvvtpCgHvfCqkCilrsLeekneCPlC 40 
                 CpiCl+ +   +p  + +C H+f+ +C  ++ +++neCP+C
  EFC39601.1  98 CPICLELYTrdNPQILCKCSHGFHFQCSEEWKQRSNECPVC 138
                 *******9544899999**************999******* PP

>> zf-RING_UBOX  RING-type zinc-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.5   4.9   1.2e-09   1.1e-06       1      39 []      98     136 ..      98     136 .. 0.90
   2 ?    2.7   0.2      0.14   1.3e+02       1       8 [.     135     142 ..     135     154 .. 0.83

  Alignments for each domain:
  == domain 1  score: 28.5 bits;  conditional E-value: 1.2e-09
  zf-RING_UBOX   1 CpIClelft..dP.lvl.pCGHtFCreClwelskslegafkCP 39 
                   CpIClel+t  +P + l +C+H F+ +C     ++++++  CP
    EFC39601.1  98 CPICLELYTrdNPqI-LcKCSHGFHFQCS---EEWKQRSNECP 136
                   ***********9953.559**********...88999999998 PP

  == domain 2  score: 2.7 bits;  conditional E-value: 0.14
  zf-RING_UBOX   1 CpIClelf 8  
                   Cp+C+  +
    EFC39601.1 135 CPVCFRKL 142
                   ****9765 PP

>> zf-rbx1  RING-H2 zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9  11.1   9.6e-09   9.1e-06      12      54 ..      96     138 ..      90     139 .. 0.88

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 9.6e-09
     zf-rbx1  12 eacieckapgdeecpvvlGeCgHaFHlhCiskWlktrkvCPlc 54 
                 + c+ c +  +++ p +l +C+H FH++C ++W +++++CP+c
  EFC39601.1  96 DICPICLELYTRDNPQILCKCSHGFHFQCSEEWKQRSNECPVC 138
                 6688888777777899999************************ PP

>> zf-C3HC4  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6  10.4   8.4e-09   7.9e-06       1      41 []      98     138 ..      98     138 .. 0.95

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 8.4e-09
                 -TTT-S--SS-E...E-TTS--B-CHHHHHHHHCTSSB--TTT CS
    zf-C3HC4   1 CpiCleeakepn..elleCkHsfCskCirkilksrkkvkCPlC 41 
                 CpiCle ++  n   l +C H f+++C +++ +  ++++CP+C
  EFC39601.1  98 CPICLELYTRDNpqILCKCSHGFHFQCSEEWKQ--RSNECPVC 138
                 ********9999889******************..7788**** PP

>> zf-C3HC4_3  Zinc finger, C3HC4 type (RING finger)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.5   6.8   1.9e-08   1.8e-05       2      46 ..      95     141 ..      94     145 .. 0.85

  Alignments for each domain:
  == domain 1  score: 24.5 bits;  conditional E-value: 1.9e-08
                 GSB-TTTSS...SBS-EEETTEEEEEE-HHHHHHHHHTT-B-TTT--B CS
  zf-C3HC4_3   2 deeCviCle...rprnvvllpCgHlvlCeeCaekllkrkkkCpiCrrp 46 
                  ++C+iCle   r+   +l++C H  +  +C+e++++r+++Cp+C r+
  EFC39601.1  95 ADICPICLElytRDNPQILCKCSHG-FHFQCSEEWKQRSNECPVCFRK 141
                 579******66434447999*****.*******************776 PP

>> zf-RING_11  RING-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.3   6.4     2e-08   1.9e-05       2      28 ..      98     124 ..      98     125 .. 0.98
   2 ?    0.7   0.1      0.49   4.6e+02       1       8 [.     134     141 ..     134     145 .. 0.84

  Alignments for each domain:
  == domain 1  score: 24.3 bits;  conditional E-value: 2e-08
  zf-RING_11   2 CsICLeefkpgqalfilpCsHtFHfkC 28 
                 C ICLe +++++  ++ +CsH FHf+C
  EFC39601.1  98 CPICLELYTRDNPQILCKCSHGFHFQC 124
                 **************9************ PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.49
  zf-RING_11   1 eCsICLee 8  
                 eC +C  +
  EFC39601.1 134 ECPVCFRK 141
                 8****865 PP

>> zf-ANAPC11  Anaphase-promoting complex subunit 11 RING-H2 finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   2.2   1.7e-06    0.0016      34      80 ..      97     141 ..      89     147 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.7e-06
                 --TTC.STTTTTS-EEEBTTS-EEEHHHHHHHHHHHSTSSB-TTTSSB CS
  zf-ANAPC11  34 tcpsc.kfpGddcplvlGkckhnfhlhcilkwletetskglcpmcrqt 80 
                  cp c ++   d p +l kc+h fh  c  +w +++   + cp+c ++
  EFC39601.1  97 ICPIClELYTRDNPQILCKCSHGFHFQCSEEWKQRS---NECPVCFRK 141
                 6999944567788999****************7654...689999654 PP

>> zf-RING_5  zinc-RING finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   9.6   1.3e-05     0.012       2      42 ..      98     138 ..      97     140 .. 0.95

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.3e-05
   zf-RING_5   2 CnkCfeklskeekfyltsCgHifCekClkkllekeavCpiC 42 
                 C++C e ++ + + +l +C+H f+ +C  + ++++++Cp+C
  EFC39601.1  98 CPICLELYTRDNPQILCKCSHGFHFQCSEEWKQRSNECPVC 138
                 ********99999*****************999******** PP

>> Zn_ribbon_17  Zinc-ribbon, C4HC2 type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   5.4   6.9e-05     0.066       7      47 ..      98     137 ..      92     141 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 6.9e-05
  Zn_ribbon_17   7 CayC.elavkgrvvlcgvCeHvlHasCarewfenddlaeCps 47 
                   C +C el  + +  +  +C H  H++C +ew +  +  eCp+
    EFC39601.1  98 CPIClELYTRDNPQILCKCSHGFHFQCSEEWKQRSN--ECPV 137
                   777755666666666679*************88888..9997 PP

>> zf-RING_4  RING/Ubox like zinc-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.9   0.1     0.051        48      34      47 ..      92     105 ..      85     106 .. 0.76
   2 ?    9.4   9.1   0.00096       0.9       1      43 [.      98     138 ..      98     142 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.9 bits;  conditional E-value: 0.051
   zf-RING_4  34 eeeegrCPaCreeY 47 
                 e+e+ +CP C e Y
  EFC39601.1  92 EDEADICPICLELY 105
                 467899****9888 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00096
   zf-RING_4   1 cplCdeeldetdkdlkpCeCgyqiClfCyhrileeeegrCPaC 43 
                 cp+C e    +d+    C+C + +   C ++ ++  ++ CP C
  EFC39601.1  98 CPICLELY-TRDNPQILCKCSHGFHFQCSEEWKQ-RSNECPVC 138
                 9***9877.88999999***********999996.69****** PP

>> Prok-RING_4  Prokaryotic RING finger family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.1     0.039        37      25      38 ..      89     103 ..      86     111 .. 0.68
   2 ?    5.2  11.9     0.021        20       3      40 ..     100     142 ..      98     145 .. 0.77

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.039
  Prok-RING_4  25 fdskdls.sCPlCqr 38 
                  f+++d +  CP+C +
   EFC39601.1  89 FEEEDEAdICPICLE 103
                  556655558****75 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.021
  Prok-RING_4   3 lCgeq...ekkailepCgHlvCkeCfdskdls..sCPlCqrri 40 
                  +C e    ++  il  C H +  +C ++++     CP+C r++
   EFC39601.1 100 ICLELytrDNPQILCKCSHGFHFQCSEEWKQRsnECPVCFRKL 142
                  5554333388899****************54445*****9986 PP

>> Zf_RING  KIAA1045 RING finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   4.9    0.0012       1.1       4      43 ..      94     134 ..      91     141 .. 0.85
   2 ?   -1.4   0.0       2.8   2.6e+03      33      45 ..     138     150 ..     134     160 .. 0.70

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0012
     Zf_RING   4 edelCeiC.evytaee.lypCRvCtkvfHegClrklgylqde 43 
                 e ++C iC e yt+++ ++ C+ C++ fH +C ++ +++++e
  EFC39601.1  94 EADICPIClELYTRDNpQILCK-CSHGFHFQCSEEWKQRSNE 134
                 5689*********987478887.***********99998765 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 2.8
     Zf_RING  33 Clrklgylqdesa 45 
                 C+rkl y+ +++ 
  EFC39601.1 138 CFRKLIYMYEDEE 150
                 8888888776655 PP

>> FANCL_C  FANCL C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   8.7    0.0081       7.6       4      46 ..      97     134 ..      94     147 .. 0.82
   2 ?    2.0   0.1      0.26   2.4e+02       3      12 ..     133     142 ..     131     162 .. 0.69

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.0081
                 S-SSS--SS-TT-----B--S-TT----B-SGGGHHHHHHHHS CS
     FANCL_C   4 eCgiCyayrldsgevpdisCdnekCnkkfHsaCLkeWlrslke 46 
                  C+iC+         p+i C   kC++ fH +C +eW +  +e
  EFC39601.1  97 ICPICLELYT--RDNPQILC---KCSHGFHFQCSEEWKQRSNE 134
                 5999998766..66799**9...8*************876655 PP

  == domain 2  score: 2.0 bits;  conditional E-value: 0.26
                 -S-SSS--SS CS
     FANCL_C   3 veCgiCyayr 12 
                  eC++C+ + 
  EFC39601.1 133 NECPVCFRKL 142
                 5788887654 PP

>> PHD  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   8.0    0.0018       1.7       1      37 [.      97     132 ..      97     141 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0018
                 SBTTTTSTTSTTSCEEEETTTSCEEETTTSSSTHSHH CS
         PHD   1 rCavCkkksdeeeelvqCdgCkrwfHqkClkpplese 37 
                 +C +C +  + ++  ++C +C++ fH +C +  ++++
  EFC39601.1  97 ICPICLELYTRDNPQILC-KCSHGFHFQCSEEWKQRS 132
                 6******77789******.6*********98776633 PP

>> zf-C3HC4_4  zinc finger of C3HC4-type, RING
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7  10.3     0.002       1.9       1      42 []      98     138 ..      98     138 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.002
  zf-C3HC4_4   1 CPiCldYLe..kPvsl.eCGhsfClsCisslqkepdgeqllCplC 42 
                 CPiCl++ +  +P  l +C h f ++C +++ + +++    Cp+C
  EFC39601.1  98 CPICLELYTrdNPQILcKCSHGFHFQCSEEWKQRSNE----CPVC 138
                 ******986447855449*********9998887744....9999 PP

>> zf-RING-like  RING-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   7.4    0.0026       2.5       1      43 []      98     138 ..      98     138 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 0.0026
  zf-RING-like   1 CeaCkeivtqG...vrCsnesCnvrlHvdCfqhyirthsskkCpkC 43 
                   C +C e+ t+    ++C+   C+  +H +C ++    ++s++Cp C
    EFC39601.1  98 CPICLELYTRDnpqILCK---CSHGFHFQCSEEWK--QRSNECPVC 138
                   666666666643336887...**********9955..77779**** PP

>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   9.5    0.0042         4       1      48 []      98     138 ..      98     138 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0042
                 ETTTTEE-SSSS--B-SS--STCCCSB-HHHHHHHHHHTCT-SB-TTT CS
       RINGv   1 CriCleeeeeseplispCkCrGslklvHesClekWldekeantqCeiC 48 
                 C iCle  + ++p i  CkC+     +H +C e+W +    +++C +C
  EFC39601.1  98 CPICLELYTRDNPQI-LCKCSH---GFHFQCSEEWKQR---SNECPVC 138
                 99****999999654.6***96...79********887...899*999 PP

>> Rad50_zn_hook  Rad50 zinc hook motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       2.8   2.6e+03       6      16 ..      68      78 ..      65      80 .. 0.77
   2 ?    1.9   0.4      0.21     2e+02       7      25 ..      84     101 ..      80     103 .. 0.83
   3 ?    8.9   0.2    0.0014       1.3      13      29 ..     126     142 ..     125     142 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.8
                   HHHHHHHHHHT CS
  Rad50_zn_hook  6 eelnkkieelk 16
                   +e +k+ie+lk
     EFC39601.1 68 LEKQKRIEKLK 78
                   67788999887 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.21
                    HHHHHHHHHTT-SEE-TTT CS
  Rad50_zn_hook   7 elnkkieelkeakgcCPlC 25 
                    ++++  ee  ea+  CP C
     EFC39601.1  84 LFEEVFEEEDEAD-ICPIC 101
                    6777788889999.9**** PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0014
                    HHHTT-SEE-TTT--EE CS
  Rad50_zn_hook  13 eelkeakgcCPlCgRel 29 
                    ee k++ + CP+C R+l
     EFC39601.1 126 EEWKQRSNECPVCFRKL 142
                    57789999*****9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (198 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1113  (0.0620782); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        19  (0.00105974); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              19  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1164.00
//
Query:       EFC39602.1  [L=616]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.2e-19   69.9   0.1    7.4e-19   68.2   0.0    2.0  2  HhH-GPD        HhH-GPD superfamily base excision DNA repair p
    9.1e-11   41.7   0.1    2.7e-09   37.0   0.1    2.5  1  NUDIX_4        NUDIX domain
    2.2e-08   33.5   0.0    6.7e-08   32.0   0.0    1.9  1  HHH            Helix-hairpin-helix motif
    0.00021   21.5   7.6    0.00038   20.7   7.6    1.4  1  EndIII_4Fe-2S  Iron-sulfur binding domain of endonuclease III
  ------ inclusion threshold ------
      0.048   14.3   0.0       0.86   10.3   0.0    2.6  2  HHH_5          Helix-hairpin-helix domain
      0.074   13.0   0.0       0.15   12.0   0.0    1.5  1  PrgU           PrgU-like protein
        3.8    8.1  12.4        6.2    7.4   0.2    3.5  3  DUF3391        Domain of unknown function (DUF3391)


Domain annotation for each model (and alignments):
>> HhH-GPD  HhH-GPD superfamily base excision DNA repair protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.2   0.0   2.9e-22   7.4e-19       1      99 [.      86     235 ..      86     242 .. 0.94
   2 ?   -3.5   0.0       5.7   1.5e+04      13      26 ..     495     508 ..     485     521 .. 0.56

  Alignments for each domain:
  == domain 1  score: 68.2 bits;  conditional E-value: 2.9e-22
                 HHHHHHTTS-HHHHHHHHHHHHHHHSHCSHHHHHHSHHHHHHHHHTTSTTHHHHHHHHHHHHHHHH................................. CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx................................. RF
     HhH-GPD   1 vsailsqqtsderanriierlferfgfptpedladadeekLrelirelGfyrrKakyikelArilv................................. 66 
                 vs+i+ qqt++e++++++ ++++r  fpt++dlada+ ++ + ++++lG+y r+a+y+ ++A+ +v                                 
  EFC39602.1  86 VSEIMLQQTQVETVKTYFLKWMKR--FPTVKDLADATVDDAVGIWSGLGYY-RRARYLYNAAKYIVekinkpikneeiisddedddeekkriiyklpdn 181
                 79**********************..8************************.*********************************************** PP

                 .....................S-SSS--TTSHHHHHHHHHHTTSSSSTTHHHHH CS
                 .....................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
     HhH-GPD  67 .....................gkpdvlivvDvhvrrilkrlrsikekktkkkve 99 
                                      ++   ++vvD +v r++ rl+ i+e+    k++
  EFC39602.1 182 vkdlmqlpgvgrytagaiasiAFSRTASVVDGNVFRVFARLKRIEEDIAVNKTA 235
                 *********************555689*****************9985555554 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 5.7
                 HHHHHHHHHHHHHS CS
                 xxxxxxxxxxxxxx RF
     HhH-GPD  13 ranriierlferfg 26 
                 +a +i+++++++f+
  EFC39602.1 495 VASKIFKQFKKTFK 508
                 34555555555554 PP

>> NUDIX_4  NUDIX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.0   0.1     1e-12   2.7e-09       7     110 .]     343     502 ..     336     502 .. 0.61

  Alignments for each domain:
  == domain 1  score: 37.0 bits;  conditional E-value: 1e-12
                 EC.TEEEEEE--TTSSSTT-EE-S..........EEE-TTS-HH.........H........................HHHHHHHS-E.......EE.. CS
     NUDIX_4   7 dd.grvllekRpekgllggLwefP..........ggeeegeele.........e........................alareelgie.......ve.. 52 
                  d +  l ekRp++ llgg w fP          +    +e++e         +                        +                v+  
  EFC39602.1 343 GDvDSCLFEKRPKETLLGGTWHFPfviiqdtkaeE----EENEEdsedeegskKkkpkkqakktkattkaaassseseH--------FiklkeflVKeg 429
                 4567899*****************99998554321....1112222233344404444444444444433222222221........022222220122 PP

                 .....EEEE....EEEEEEETTEEEEEEEEEE.......EEE.S..---EEEEEEGGGGGGS---CCCHCCHHH CS
     NUDIX_4  53 .....elep....gtvkHvftHfrltltvylv.......rveegeeapaelrwvtpeeleeyalptavrkllea 110
                      ++ p     +v HvftH+  t ++y +       ++e+ ++++++++w+  ++ +  +++t+  k++++
  EFC39602.1 430 fvqdkSI-PfeyhASVDHVFTHINQTNHIYSCsdkylikDLEDSNSEEDQWKWFANSQRKSQGISTVASKIFKQ 502
                 3323322.334456899*******************9887775555555*********************9985 PP

>> HHH  Helix-hairpin-helix motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.0   0.0   2.6e-11   6.7e-08       5      30 .]     177     202 ..     173     202 .. 0.91

  Alignments for each domain:
  == domain 1  score: 32.0 bits;  conditional E-value: 2.6e-11
                 HHTSSHHHHHTSTT-SHHHHHHHHHH CS
         HHH   5 lipasreeLlalPGVGpktAeaIlsy 30 
                   p+++++L++lPGVG++tA+aI+s+
  EFC39602.1 177 KLPDNVKDLMQLPGVGRYTAGAIASI 202
                 579********************986 PP

>> EndIII_4Fe-2S  Iron-sulfur binding domain of endonuclease III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   7.6   1.5e-07   0.00038       1      17 []     287     303 ..     287     303 .. 0.99

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 1.5e-07
  EndIII_4Fe-2S   1 CTARkPkCeaCPLaDlC 17 
                    C +R+PkC +CPLa+ C
     EFC39602.1 287 CIPRNPKCTECPLAEVC 303
                    9***************9 PP

>> HHH_5  Helix-hairpin-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.37   9.6e+02      23      36 ..     110     123 ..     104     132 .. 0.83
   2 ?   10.3   0.0   0.00034      0.86       2      48 ..     183     230 ..     182     232 .. 0.82

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.37
                 --SHHHHHHS-HHH CS
       HHH_5  23 iesvedlaaadvee 36 
                 + +v dla+a+v++
  EFC39602.1 110 FPTVKDLADATVDD 123
                 789*******9987 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00034
                 HHHHTSTT--HHHHHHHHTTT--SHHHHHHS-H.HHHHTSTTS-HHHH CS
       HHH_5   2 eeLlsvsGiGpktAlallsaGiesvedlaaadv.eeLakipGiGkktA 48 
                 ++L++++G+G+ tA a++s  ++  + +++ +v   +a+++ i ++ A
  EFC39602.1 183 KDLMQLPGVGRYTAGAIASIAFSRTASVVDGNVfRVFARLKRIEEDIA 230
                 799***************998888899999988555777888877766 PP

>> PrgU  PrgU-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0     6e-05      0.15       5     104 ..     257     358 ..     253     360 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 6e-05
        PrgU   5 aiqekdltlqwrgn.tgklvkvrlkntramemwynkqiteeniqeittlniikngksla.levypeksiyvkpnlgrinvpvffiktpinrgvfeeifg 101
                  +++ dl l+ r n tg + +  +   r++ +  n + te  + e+   n   +   +a +e+yp k    k     +   +f+    ++  +fe+   
  EFC39602.1 257 VLEKEDLELKHRYNvTGDFNQAVMELGRTVCIPRNPKCTECPLAEVCEANKALEKEEIAtVEIYPVKNKKTKKRTQVVSCCIFYKEGDVDSCLFEKRPK 355
                 566789******986899*****************************99976665555439*********************************99888 PP

        PrgU 102 etl 104
                 etl
  EFC39602.1 356 ETL 358
                 876 PP

>> DUF3391  Domain of unknown function (DUF3391)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.0       0.2   5.1e+02      67     126 ..      66     156 ..      49     162 .. 0.68
   2 ?    7.4   0.2    0.0024       6.2      53     115 ..     370     416 ..     359     459 .. 0.56
   3 ?    1.5   5.6      0.16     4e+02      65     125 ..     532     592 ..     489     610 .. 0.67

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.2
     DUF3391  67 dvpaaeaaeeakaaeesaeleeekqerperleaere...............................eleraeklyeeakqlvrslfsdvr 126
                 d+++  +a+e+ ++++ + l +e+  ++++ e+ ++                                ++ra+ ly+ ak +v+++ + ++
  EFC39602.1  66 DEDDDVKATEELHQRAYEVLVSEIMLQQTQVETVKTyflkwmkrfptvkdladatvddavgiwsglgYYRRARYLYNAAKYIVEKINKPIK 156
                 3344444445555555555555555555555555558888888888888888888888888888888889999999999999988876655 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0024
     DUF3391  53 idtdksdeeelagldvpaaeaaeeakaaeesaeleeekqerperleaereeleraeklyeeak 115
                 i+  k +eee++++d++++e                 k+++p+++ ++ ++ ++a++  +e++
  EFC39602.1 370 IQDTK-AEEEENEEDSEDEEGS---------------KKKKPKKQAKKTKATTKAAASSSESE 416
                 44444.2233333333333222...............22222222222233333333333333 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.16
     DUF3391  65 gldvpaaeaaeeakaaeesaeleeekqerperleaereeleraeklyeeakqlvrslfsdv 125
                 + +++++  ++++  +e+ ++ e  + +++e++e+ ++e+++++   + +k+++++  ++ 
  EFC39602.1 532 SAETKEENSESSSSDEEVMKDDEVVRISKQEVKEKVKDEIKQVKMETRLSKRVAKRTSEES 592
                 2333344444444444444444444444455555555588888888888888887766655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (616 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2824  (0.15751); expected 358.6 (0.02)
Passed bias filter:                      546  (0.0304535); expected 358.6 (0.02)
Passed Vit filter:                       106  (0.00591221); expected 17.9 (0.001)
Passed Fwd filter:                        38  (0.00211947); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.97u 0.38s 00:00:01.35 Elapsed: 00:00:00.57
# Mc/sec: 3253.05
//
Query:       EFC39603.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.7e-36  120.5  16.4    0.00096   19.0   0.0    9.7 10  LRR_6     Leucine Rich repeat
    8.5e-19   67.4  22.9     0.0025   18.2   0.3    6.6  8  LRR_4     Leucine Rich repeats (2 copies)
    7.9e-18   64.0  22.6    1.2e-06   28.2   0.4    5.7  6  LRR_8     Leucine rich repeat
    7.8e-05   22.7  11.4         44    5.2   0.1    8.8  9  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
      0.037   13.9   0.4       0.12   12.2   0.2    2.0  2  YqbF      YqbF, hypothetical protein domain
      0.038   13.5   5.2        6.8    6.2   0.1    3.7  5  LRR_9     Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.9   0.0   0.00057       1.7       4      23 ..     102     121 ..     101     122 .. 0.91
   2 !   15.3   0.0   5.1e-06     0.015       4      24 .]     126     146 ..     123     146 .. 0.93
   3 !    6.5   0.1    0.0034        10       4      23 ..     150     169 ..     147     170 .. 0.88
   4 !   14.6   0.0   8.1e-06     0.024       5      19 ..     175     189 ..     172     194 .. 0.88
   5 !   14.0   0.0   1.3e-05     0.038       3      24 .]     221     242 ..     219     242 .. 0.91
   6 !   19.0   0.0   3.2e-07   0.00096       5      24 .]     247     266 ..     244     266 .. 0.95
   7 !   18.4   0.7   4.9e-07    0.0015       3      24 .]     269     290 ..     267     290 .. 0.92
   8 !   15.7   0.0   3.6e-06     0.011       3      23 ..     294     314 ..     292     315 .. 0.91
   9 !   10.1   0.2   0.00024      0.72       3      16 ..     318     331 ..     316     332 .. 0.90
  10 ?   -3.1   0.0         4   1.2e+04       5      14 ..     344     353 ..     343     353 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00057
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt L++ +N +g eGa+ +
  EFC39603.1 102 KLTRLSIDYNRVGVEGASFI 121
                 79***************976 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 5.1e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L++ +N+Ig eGa++++
  EFC39603.1 126 NLTSLSILFNGIGPEGAKSIS 146
                 8*****************996 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0034
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt+L ++ N++g eG +++
  EFC39603.1 150 NLTSLFINVNQLGSEGTKSI 169
                 89**************8887 PP

  == domain 4  score: 14.6 bits;  conditional E-value: 8.1e-06
       LRR_6   5 LteLdLsgNdIgDeG 19 
                 Lt Ld+sgN++g eG
  EFC39603.1 175 LTCLDISGNHLGPEG 189
                 9*************9 PP

  == domain 5  score: 14.0 bits;  conditional E-value: 1.3e-05
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 + Lt L++s+N I+ eGa+ L+
  EFC39603.1 221 RQLTILNVSYNYIDSEGAKYLS 242
                 579***************9885 PP

  == domain 6  score: 19.0 bits;  conditional E-value: 3.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L + +N+Ig eGa++++
  EFC39603.1 247 LTTLRIDSNNIGPEGAKSIC 266
                 9*****************98 PP

  == domain 7  score: 18.4 bits;  conditional E-value: 4.9e-07
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++Lt L++ +N IgDeG+ +++
  EFC39603.1 269 QNLTNLNVDSNAIGDEGILSIS 290
                 89****************9986 PP

  == domain 8  score: 15.7 bits;  conditional E-value: 3.6e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                  +L++L+ s N+IgDeGa+++
  EFC39603.1 294 KNLKYLNASMNGIGDEGAQSI 314
                 58****************998 PP

  == domain 9  score: 10.1 bits;  conditional E-value: 0.00024
       LRR_6   3 thLteLdLsgNdIg 16 
                 t Lt L++s+N+Ig
  EFC39603.1 318 TQLTNLNISCNKIG 331
                 77***********8 PP

  == domain 10  score: -3.1 bits;  conditional E-value: 4
       LRR_6   5 LteLdLsgNd 14 
                 L  L++ +N+
  EFC39603.1 344 LVILEIGFNK 353
                 77899*9996 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.1   0.0   1.6e-05     0.048       1      36 [.     101     137 ..     101     150 .. 0.79
   2 !    6.7   0.2    0.0034        10      20      37 ..     146     162 ..     137     173 .. 0.75
   3 !   15.9   0.8   4.5e-06     0.013       2      35 ..     150     184 ..     149     191 .. 0.86
   4 !   11.6   0.4   9.6e-05      0.29       1      36 [.     173     209 ..     173     221 .. 0.79
   5 !   10.4   0.2   0.00024      0.71       1      37 [.     197     234 ..     197     240 .. 0.85
   6 !   14.6   0.2   1.1e-05     0.034       2      36 ..     222     257 ..     221     261 .. 0.86
   7 !   18.2   0.3   8.4e-07    0.0025       1      37 [.     269     307 ..     269     316 .. 0.86
   8 !   13.7   0.5   2.1e-05     0.064       1      35 [.     318     353 ..     318     355 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 1.6e-05
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L+ L++  N++   +  + + ++nL++L++ +N  i
  EFC39603.1 101 KKLTRLSIDYNRVGVEGAsFIGeMKNLTSLSILFN-GI 137
                 69**********99666676666********9888.55 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0034
                 HH-TT--EEE-.-S---- CS
       LRR_4  20 eklpnLkeLdLsgNnlit 37 
                 +kl nL++L + + n+++
  EFC39603.1 146 SKLENLTSLFI-NVNQLG 162
                 46999999999.666884 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 4.5e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 nL++L ++ Nql + +   ++ l++L+ Ld+sgN  
  EFC39603.1 150 NLTSLFINVNQLGSEGTksISELKQLTCLDISGN-H 184
                 9*******99***988886445***********9.3 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 9.6e-05
                 SS--EEE--SS---.E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqlt.dipl..leklpnLkeLdLsgNnli 36 
                 ++L+ Ld+s+N+l  + +   ++kl++L++L +  Nn i
  EFC39603.1 173 KQLTCLDISGNHLGpE-GTkyIGKLTQLTQLII-CNNEI 209
                 589***********44.4467778*******87.55565 PP

  == domain 5  score: 10.4 bits;  conditional E-value: 0.00024
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 ++L+ L + nN + +  l + + l +L+ L++s N +i+
  EFC39603.1 197 TQLTQLIICNNEIYSERLkFIGeLRQLTILNVSYN-YID 234
                 689999******99988886655*********999.885 PP

  == domain 6  score: 14.6 bits;  conditional E-value: 1.1e-05
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 +L++L+ s N + + +   l+ +++L++L + +N +i
  EFC39603.1 222 QLTILNVSYNYIDSEGAkyLSEMKQLTTLRIDSN-NI 257
                 69************99998778*********666.34 PP

  == domain 7  score: 18.2 bits;  conditional E-value: 8.4e-07
                 SS--EEE--SS---E-S-HH...H-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpnLkeLdLsgNnlit 37 
                 +nL++L+  +N + d + l+   k++nLk+L+ s N  i+
  EFC39603.1 269 QNLTNLNVDSNAIGDEGILSiseKMKNLKYLNASMN-GIG 307
                 79*************999777779********8445.665 PP

  == domain 8  score: 13.7 bits;  conditional E-value: 2.1e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 ++L++L++s N++ +  l  ++++++L  L + g+n+
  EFC39603.1 318 TQLTNLNISCNKIGENVLklFGGMKQLVILEI-GFNK 353
                 68*******99***999998889*********.5444 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       2.5   7.5e+03      35      45 ..      36      46 ..      35      47 .. 0.51
   2 !   17.2   1.1   1.1e-06    0.0033       2      61 .]     102     161 ..     101     161 .. 0.95
   3 !   22.0   3.9   3.5e-08    0.0001       2      61 .]     126     185 ..     125     185 .. 0.98
   4 !   28.2   0.4     4e-10   1.2e-06       2      61 .]     198     257 ..     197     257 .. 0.98
   5 !   12.8   3.7   2.5e-05     0.074       2      61 .]     270     330 ..     269     330 .. 0.94
   6 !   15.8   1.3     3e-06    0.0088       2      60 ..     295     353 ..     294     353 .. 0.89

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.5
                S---GGGGGGG CS
       LRR_8 35 Nllttlspgaf 45
                N +t +s ++f
  EFC39603.1 36 NYCTKISSQWF 46
                45555555555 PP

  == domain 2  score: 17.2 bits;  conditional E-value: 1.1e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L+++ Nr  + + ++   ++nL++L++  N +    ++++s L++L+sL ++ N+L
  EFC39603.1 102 KLTRLSIDYNRVGVEGASFIGEMKNLTSLSILFNGIGPEGAKSISKLENLTSLFINVNQL 161
                 79*********99888888888**********************************9997 PP

  == domain 3  score: 22.0 bits;  conditional E-value: 3.5e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLtsL++ +N +   + ++ ++l+nL++L ++ N+l +   +++s L++L+ Ld+sgN+L
  EFC39603.1 126 NLTSLSILFNGIGPEGAKSISKLENLTSLFINVNQLGSEGTKSISELKQLTCLDISGNHL 185
                 9*********************************************************98 PP

  == domain 4  score: 28.2 bits;  conditional E-value: 4e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L+++nN + s + ++   l++L++L+ s+N +++  ++ +s +++L+ L +++N++
  EFC39603.1 198 QLTQLIICNNEIYSERLKFIGELRQLTILNVSYNYIDSEGAKYLSEMKQLTTLRIDSNNI 257
                 89********************************************************97 PP

  == domain 5  score: 12.8 bits;  conditional E-value: 2.5e-05
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+L++++N + + +  + +  ++nLk+L+ s N +    ++++ ++++L+ L++s N++
  EFC39603.1 270 NLTNLNVDSNAIGDEGILSISEkMKNLKYLNASMNGIGDEGAQSILSMTQLTNLNISCNKI 330
                 9**********999998888888**********************************9987 PP

  == domain 6  score: 15.8 bits;  conditional E-value: 3e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 nL++L+ s N + + + ++  ++++L+ L++s+N++     + f g+++L  L +  N+
  EFC39603.1 295 NLKYLNASMNGIGDEGAQSILSMTQLTNLNISCNKIGENVLKLFGGMKQLVILEIGFNK 353
                 78899999999999999999999999999999999999889999999999999998885 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0       0.5   1.5e+03       1      12 [.     102     113 ..     102     124 .. 0.79
   2 ?   -1.2   0.0       1.8   5.5e+03       1      22 [.     126     147 ..     126     148 .. 0.69
   3 ?    1.0   0.1      0.34     1e+03       1      20 [.     150     169 ..     150     172 .. 0.77
   4 ?    5.2   0.1     0.015        44       2      12 ..     175     185 ..     174     206 .. 0.75
   5 ?    4.3   0.0     0.029        86       1      20 [.     222     241 ..     222     244 .. 0.80
   6 ?    2.1   0.0      0.15   4.5e+02       1      21 [.     246     266 ..     246     268 .. 0.74
   7 ?    1.0   0.1      0.36   1.1e+03       1      19 [.     270     288 ..     270     291 .. 0.77
   8 ?    3.3   0.0     0.063   1.9e+02       1      21 [.     295     315 ..     295     317 .. 0.87
   9 ?    1.3   0.1      0.29   8.6e+02       2      12 ..     320     330 ..     319     341 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.5
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L + +n+ 
  EFC39603.1 102 KLTRLSIDYNRV 113
                 79*******986 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 1.8
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL++L +  n ++  ++ s+++
  EFC39603.1 126 NLTSLSILFNGIGPEGAKSISK 147
                 8999999777776666666655 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.34
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nL++L ++ n+l++ +  s+
  EFC39603.1 150 NLTSLFINVNQLGSEGTKSI 169
                 8*********9976665555 PP

  == domain 4  score: 5.2 bits;  conditional E-value: 0.015
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ Ld+s+n+l
  EFC39603.1 175 LTCLDISGNHL 185
                 899*******9 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.029
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L+ L++s+n +++ ++ ++
  EFC39603.1 222 QLTILNVSYNYIDSEGAKYL 241
                 599********987776665 PP

  == domain 6  score: 2.1 bits;  conditional E-value: 0.15
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L + +n+++  ++ s++
  EFC39603.1 246 QLTTLRIDSNNIGPEGAKSIC 266
                 599****99998666666655 PP

  == domain 7  score: 1.0 bits;  conditional E-value: 0.36
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL+ L++ +n +++ ++ s
  EFC39603.1 270 NLTNLNVDSNAIGDEGILS 288
                 899******9886666555 PP

  == domain 8  score: 3.3 bits;  conditional E-value: 0.063
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nL++L+ s n +++ +++s+ 
  EFC39603.1 295 NLKYLNASMNGIGDEGAQSIL 315
                 8*********99999988876 PP

  == domain 9  score: 1.3 bits;  conditional E-value: 0.29
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ L++s n +
  EFC39603.1 320 LTNLNISCNKI 330
                 899*****987 PP

>> YqbF  YqbF, hypothetical protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0      0.96   2.9e+03      33      40 ..      44      51 ..      42      54 .. 0.85
   2 ?   12.2   0.2   4.1e-05      0.12      13      34 ..      55      76 ..      52      85 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.96
                TTEEEEE- CS
        YqbF 33 efFevree 40
                 +F v++e
  EFC39603.1 44 QWFRVIKE 51
                79****98 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 4.1e-05
                EEBT-EEEE-HHHHHHHHHSTT CS
        YqbF 13 FklgveedVekeiynYLqdnef 34
                F l+ e ++++e ++YL + ef
  EFC39603.1 55 FSLNFEHKINNERVDYLMKSEF 76
                999***************9998 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.0      0.14   4.3e+02      89     125 ..      79     113 ..      61     119 .. 0.70
   2 ?    0.7   0.1       0.1   3.1e+02     107     124 ..     119     136 ..      90     154 .. 0.58
   3 ?    4.6   0.0     0.007        21      63     124 ..     124     184 ..     107     202 .. 0.79
   4 ?    6.2   0.1    0.0023       6.8      63     146 ..     148     227 ..     141     239 .. 0.66
   5 ?    5.5   0.5    0.0036        11      60     124 ..     241     305 ..     220     325 .. 0.76

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.14
       LRR_9  89 nleelvltnnelqeladldPlaslkklellsllknpv 125
                 n+ e+ + n     +ad+  l  +kkl+ ls+  n v
  EFC39603.1  79 NIMEVTVENPG--LIADVRFLQAVKKLTRLSIDYNRV 113
                 55444444443..368899999999999999977766 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.1
       LRR_9 107 dPlaslkklellsllknp 124
                   + ++k+l++ls+l n 
  EFC39603.1 119 SFIGEMKNLTSLSILFNG 136
                 334456666666666654 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.007
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                 +k l +l++  n i   + +    l nl++l ++ n+l + ++ + + +lk+l++l +  n 
  EFC39603.1 124 MKNLTSLSILFNGIGPEGAKSISKLENLTSLFINVNQLGSEGT-KSISELKQLTCLDISGNH 184
                 5666677777777777777777788999999999999999988.899999999999887775 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0023
       LRR_9  63 lkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                 l+ l +l++n n++   + +    l +l++l +++n+l   ++ + + +l +l+ l + +n + ++   rl  i  l+ql++l+
  EFC39603.1 148 LENLTSLFINVNQLGSEGTKSISELKQLTCLDISGNHLGPEGT-KYIGKLTQLTQLIICNNEIYSE---RLKFIGELRQLTILN 227
                 5666777777777776666666667777777777777776666.6666677777766666666543...566666666666664 PP

  == domain 5  score: 5.5 bits;  conditional E-value: 0.0036
       LRR_9  60 fPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknp 124
                 +  +k+l tl +++n i   + +   +l nl++l + +n + + + l    ++k+l++l    n 
  EFC39603.1 241 LSEMKQLTTLRIDSNNIGPEGAKSICTLQNLTNLNVDSNAIGDEGILSISEKMKNLKYLNASMNG 305
                 44578888999999999988888888999999999999999999999888899999988766555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       365  (0.0203581); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 2352.53
//
Query:       EFC39604.1  [L=447]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
        3.5    6.9   8.0       0.29   10.4   1.0    2.5  3  FtsK_SpoIIIE   FtsK/SpoIIIE family
        7.2    6.7  50.1       0.29   11.2   8.4    5.2  5  DUF1664        Protein of unknown function (DUF1664)


Domain annotation for each model (and alignments):
>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   1.0   3.3e-05      0.29     102     187 ..      13      97 ..       6     111 .. 0.81
   2 ?   -0.4   0.6     0.065   5.8e+02     106     126 ..     151     171 ..     128     251 .. 0.60
   3 ?   -2.5   0.1       0.3   2.7e+03     124     164 ..     222     258 ..     202     305 .. 0.54

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 3.3e-05
                   HHHHHHHHHHHHHHHHHHHHHHHHTT-SSHHHHHHHHHHHHHTT---B-TT-......................-----------B CS
  FtsK_SpoIIIE 102 peralraleeLvkemeeryalfreagvrsiaaydgeiaedpldifgdvflvlDnyddlaaeneritsLsnqgpsygvhvlvtagre 187
                    e+++  le+   ++++  + ++e+  +++++++++ ++++++ f+ + l +D  ++  ++n +  +L + g++  v++l ++ ++
    EFC39604.1  13 KEEVMTRLEKSSGKLQRTNEALQEQLKQERNKAEEQYQKAKQE-FEQIRLAIDSCKKSTTRNDQLFALLKDGLEQKVEILQEQLAQ 97 
                   5677777888888899999999999999999988888887777.899********************************9887443 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.065
                   HHHHHHHHHHHHHHHHHHHHT CS
  FtsK_SpoIIIE 106 lraleeLvkemeeryalfrea 126
                   l++l++L++e++e  ++ +++
    EFC39604.1 151 LNLLNQLCEELREKNEIVQKT 171
                   556666666666666444332 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 0.3
                   HHTT-SSHHHHHHHHHHHHHTT---B-TT-........... CS
  FtsK_SpoIIIE 124 reagvrsiaaydgeiaedpldifgdvflvlDnyddlaaene 164
                        ++i+++ + ++e+++++ +    +l    +l+++ne
    EFC39604.1 222 ITVLENQIESATKNMKEQEKKSAKYKKAYL----ELRQKNE 258
                   444444444444444444444333222222....3333333 PP

>> DUF1664  Protein of unknown function (DUF1664)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.9   4.4   0.00068       6.1      59     113 ..      11      66 ..       7      75 .. 0.82
   2 ?   -1.2  11.8      0.23     2e+03      58     124 .]     120     186 ..      84     186 .. 0.88
   3 ?    4.8   2.2    0.0031        27      58     109 ..     219     270 ..     196     277 .. 0.81
   4 ?    2.3   0.6     0.018   1.6e+02      56     121 ..     252     317 ..     244     325 .. 0.65
   5 ?   11.2   8.4   3.3e-05      0.29      54     119 ..     320     392 ..     286     397 .. 0.80

  Alignments for each domain:
  == domain 1  score: 6.9 bits;  conditional E-value: 0.00068
     DUF1664  59 atkrhLssridrvdkkldeqke.iskeikeevtevredlseigedvesvkeavegl 113
                 ++k++ + r+++   kl+ ++e +++++k+e ++++e+ ++ ++++e+++ a+ + 
  EFC39604.1  11 SQKEEVMTRLEKSSGKLQRTNEaLQEQLKQERNKAEEQYQKAKQEFEQIRLAIDSC 66 
                 78999999999999999987652688999999999999999999999999888765 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.23
     DUF1664  58 aatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveglesklerieekQ 124
                 ++  ++Ls++i++++++ ++ ++ s++ k+e++ +++  +e++e+ e v+++v+  e + + ++e+Q
  EFC39604.1 120 RNMNENLSEKINELQDENKSLIQSSEKDKAELNLLNQLCEELREKNEIVQKTVQLNEDQFQMLKEQQ 186
                 556789************************************************9999999998887 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.0031
     DUF1664  58 aatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkea 109
                 ++    L+++i++  k+++eq++ s++ k+   e+r++ ++++ +++ + +a
  EFC39604.1 219 QKIITVLENQIESATKNMKEQEKKSAKYKKAYLELRQKNEQLEGEIKVLTHA 270
                 5555668999999999999999999999999999999999999999988765 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.018
     DUF1664  56 slaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeaveglesklerie 121
                 +l++  ++L+ +i+ + +  ++   +   + e  +++++++  + +++e++ + + +l++k +++e
  EFC39604.1 252 ELRQKNEQLEGEIKVLTHASQDRDLLRDRVVELTKTAENEMLLTTQNMEKLMTRFGNLDEKSTQLE 317
                 566666677777777666666666666666666666666666666777777777777777666665 PP

  == domain 5  score: 11.2 bits;  conditional E-value: 3.3e-05
     DUF1664  54 s.......eslaatkrhLssridrvdkkldeqkeiskeikeevtevredlseigedvesvkeavegleskler 119
                         +  a+  ++L++++  +++k + q+++ +e+++++++++++ ++ +e ++  +e+v +le++++r
  EFC39604.1 320 ElkacyerDRFAEENKELKNKVSDLNSKYETQMKLVNELTSQLKSLKKKKNDYKESSKRNQELVLELEEQVNR 392
                 344444657889999******************************************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (447 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      4266  (0.237939); expected 358.6 (0.02)
Passed bias filter:                      517  (0.028836); expected 358.6 (0.02)
Passed Vit filter:                       203  (0.0113224); expected 17.9 (0.001)
Passed Fwd filter:                        94  (0.0052429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 1.78u 0.34s 00:00:02.12 Elapsed: 00:00:00.68
# Mc/sec: 1989.60
//
Query:       EFC39605.1  [L=477]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (477 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       869  (0.048469); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 2902.21
//
Query:       EFC39606.1  [L=332]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    6.7e-27   94.1  15.0    4.9e-13   49.6   1.1    3.5  3  Big_9       Bacterial Ig domain
      2e-13   50.1   7.7      9e-07   28.8   1.8    2.3  2  Cadherin_5  Cadherin-like domain
    6.6e-13   49.1  12.1    4.4e-09   36.8   0.6    3.7  3  Cadherin_4  Bacterial cadherin-like domain
  ------ inclusion threshold ------
      0.066   12.2   0.0      0.093   11.7   0.0    1.1  1  Vps16_C     Vps16, C-terminal region


Domain annotation for each model (and alignments):
>> Big_9  Bacterial Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.6   1.1   1.1e-16   4.9e-13      11      87 ..      57     134 ..      47     136 .. 0.87
   2 !   41.8   3.8     3e-14   1.4e-10       1      89 [.     138     242 ..     138     243 .. 0.80
   3 !    8.7   0.0   0.00064       2.9       1      18 [.     244     261 ..     244     282 .. 0.89

  Alignments for each domain:
  == domain 1  score: 49.6 bits;  conditional E-value: 1.1e-16
       Big_9  11 vndaPvavddsvtvt.....edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsD 87 
                    +Pva++d +++      + +vl nd dp g +lt+t+    +v++p++Gtv i +  +++y+   +fsg+d+f+Y vs+
  EFC39606.1  57 GYNPPVAANDFASTYkrmpvTVDVLINDNDPRGGNLTLTQ----IVNQPKYGTVKILSRSQVVYQSIGSFSGNDTFSYEVSN 134
                 4679**********966666666699**********9775....69**********************************97 PP

  == domain 2  score: 41.8 bits;  conditional E-value: 3e-14
       Big_9   1 tatvtvtvtpvndaPvavddsvtvtedsv.............landtdpdgdaltvtsltvtlvta...panGtvtinadgtltytpnagfsgtdsftY 83 
                 ta++tvtv+  n++P av+    ++++                +  +d+d+d l vt +  ++v +   ++ G++++++ + + ytp +gf+g + f+Y
  EFC39606.1 138 TANATVTVQVLNRPPQAVPIYKKISKNAHkalvdifnyvgdnDERISDIDNDVLYVTGFADQQVISgnaQSLGSIEVDTYNGFLYTPVTGFNGIEKFNY 236
                 78999999999********9955553333335455444433344889********9998766665577799********99****************** PP

       Big_9  84 tvsDgs 89 
                 t+sDg+
  EFC39606.1 237 TISDGN 242
                 ****97 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.00064
       Big_9   1 tatvtvtvtpvndaPvav 18 
                 ta+ tvtv+ +ndaP+a 
  EFC39606.1 244 TASSTVTVEVENDAPIAG 261
                 78999999999*****95 PP

>> Cadherin_5  Cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.4   4.2e-09   1.9e-05      13      96 ..      67     146 ..      58     148 .. 0.82
   2 !   28.8   1.8     2e-10     9e-07      33      97 ..     183     253 ..     181     254 .. 0.83

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 4.2e-09
  Cadherin_5  13 laagseDtaltitaaqLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttataslt 96 
                  a++ +  ++t++   +L n+ D+ g +L+ +++  + + Gtv   +  +++++    ++G+ t+sY+vs     t++at++++
  EFC39606.1  67 FASTYKRMPVTVD---VLINDNDPRGGNLTLTQIVNQPKYGTVKILSRSQVVYQSIGSFSGNDTFSYEVSNSF-VTANATVTVQ 146
                 4555566666666...9*****************99999*******************************996.5555555555 PP

  == domain 2  score: 28.8 bits;  conditional E-value: 2e-10
  Cadherin_5  33 asDvdgdtLsvsslta.......daenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasltv 97 
                 +sD+d+d L v++ +        +++ G++  +    f +tp + +nG  +++Yt+sDg+  t+++t++++v
  EFC39606.1 183 ISDIDNDVLYVTGFADqqvisgnAQSLGSIEVDTYNGFLYTPVTGFNGIEKFNYTISDGN-DTASSTVTVEV 253
                 69**********9954567777666679998777777**********************8.77778888776 PP

>> Cadherin_4  Bacterial cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.6   9.9e-13   4.4e-09      11      67 ..      58     111 ..      47     130 .. 0.85
   2 !   10.1   1.5   0.00022      0.97       1      55 [.     139     202 ..     139     226 .. 0.64
   3 !    7.8   0.1    0.0011       5.1       1      16 [.     245     260 ..     245     269 .. 0.90

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 9.9e-13
  Cadherin_4  11 ndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlnad 67 
                  ++Pva++d a++    p+t+   +vl nd+D+ g+ lt t++  ++ yGt+ + + 
  EFC39606.1  58 YNPPVAANDFASTYKRMPVTV---DVLINDNDPRGGNLTLTQIVNQPKYGTVKILSR 111
                 579******************...9****************9999******776554 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00022
  Cadherin_4   1 atvtitvtgvndaPvavddsatvtedtpltita..gnvland...tDvdgddltvtavt....v 55 
                 a++t+tv+  n +P av+    +  ++     +    v +nd   +D+d+d l vt+++    +
  EFC39606.1 139 ANATVTVQVLNRPPQAVPIYKKISKNAHKALVDifNYVGDNDeriSDIDNDVLYVTGFAdqqvI 202
                 6899**************87666665544433222334455444499*********99733331 PP

  == domain 3  score: 7.8 bits;  conditional E-value: 0.0011
  Cadherin_4   1 atvtitvtgvndaPva 16 
                 a+ t+tv+  ndaP+a
  EFC39606.1 245 ASSTVTVEVENDAPIA 260
                 5679***********9 PP

>> Vps16_C  Vps16, C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   2.1e-05     0.093      75     114 ..     145     184 ..     130     206 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.1e-05
     Vps16_C  75 fkllredplalklYkkfmkksdratLydlynq.dDnkqela 114
                  ++l+  p a+++Ykk+ k + ++ L d++n   Dn + ++
  EFC39606.1 145 VQVLNRPPQAVPIYKKISK-NAHKALVDIFNYvGDNDERIS 184
                 5899***************.788889999974256666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (332 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       896  (0.0499749); expected 358.6 (0.02)
Passed bias filter:                      568  (0.0316805); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 1914.88
//
Query:       EFC39607.1  [L=963]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.7e-65  221.4   0.0    1.1e-36  126.8   0.0    2.3  2  Beta-lactamase   Beta-lactamase
  ------ inclusion threshold ------
      0.044   13.8   0.0      0.099   12.7   0.0    1.5  1  DUF4715          Domain of unknown function (DUF4715)
      0.064   12.9   0.0         17    4.9   0.0    3.1  3  Beta-lactamase2  Beta-lactamase enzyme family
      0.071   12.4   0.1       0.18   11.1   0.1    1.6  1  FAM194           FAM194 protein


Domain annotation for each model (and alignments):
>> Beta-lactamase  Beta-lactamase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  126.8   0.0   2.4e-40   1.1e-36      16     323 ..      58     376 ..      49     382 .. 0.82
   2 !   92.1   0.0   8.8e-30   3.9e-26      19     314 ..     553     822 ..     540     833 .. 0.78

  Alignments for each domain:
  == domain 1  score: 126.8 bits;  conditional E-value: 2.4e-40
                     EEEEEEEETTEEEEEEEEEEEETTTTEEESTTSBEEEGGGHHHHHHHHHHHHHHTTSSCTTSBGGGTST.....TCTTGGGTTEBHHHHHTTHSS CS
  Beta-lactamase  16 GvavavvrdgkvvldkggGvadleggrpvtadtlfriaSvtKtftaaavlqlveeGkldLddpVskylP.....efagpgkgkiTlrdLltHtsG 105
                     G++ a++ ++++v +  +G   ++g+++ t dt +riaSvtKtf++aa+++l +eG++dLd+ V++ +P     + ++    + T r+L ++ sG
      EFC39607.1  58 GASTAILFRNETVGEVFAG--IAQGNQKPTRDTKYRIASVTKTFVSAAMMALRDEGLIDLDQSVCDFVPefctfPNPDGLSSNFTFRQLSSYLSG 150
                     7888888888888777776..477888*********************************************99778888899************ PP

                     CSSSSTSTTCTSHHHTHHHHHHHHHH..SBSSSSTTSCEE-SHHHHHHHHHHHHHHHTSHHHHHHHHHTTTTTTSTTEES.STTGGGGGGBEEEE CS
  Beta-lactamase 106 lpdlfasdlleeaaadaaellralat..lppkyapGtkwgYsntgygllgellekvtgrsleqllreeilrpLgmkdtel.gppesgdprdaagy 197
                     lp++ a+  l+  ++   ++++++++  l ++++  +  +Ysn+gy+ lg++le +++ s+eq ++ +il+ Lgmk+ ++ + +      +a gy
      EFC39607.1 151 LPRE-APCVLTACDYSNGQIMQRIKEngLFLVRDGDHYPIYSNLGYSFLGHALESAAKISFEQVIQSRILDKLGMKNSGFvNKDNLNNLILAEGY 244
                     *999.5555555555667******982255788899999******************999******************9835666788999**** PP

                     EEETCEEECSCETTHHHHCTTTBEEEEHHHHHHHH.........HHHHHCCSSSSHHHHHHHHHHHTSEEEECTTEEEECECSSEEEEECCH.TE CS
  Beta-lactamase 198 tgngpearappanlpaeaegagglistardlarfl.........glalegglllsaetlaqltaklssgttrpagiraglglGwvladktga.pg 282
                     +++ + +  +    +++  +a+g++s+++dl  ++          + + ++++ s++tl+++     + ++  + + a++gl w + +++   ++
      EFC39607.1 245 HESERIYTNNKTISWSQ--PAAGMYSSIADLTLYVknlmnafanYGNKMETSIMSRQTLREF----LNAQHVLPHGSAAVGLSWEMVHYPFLgGW 333
                     99888888888888888..89**************999975444333333333333333333....44444444455556999998888888899 PP

                     EEEEEE..STEEEEEEEECGGTEEEEEEESBCSSHHHHHHHHH CS
  Beta-lactamase 283 tfghtG..ggygtyvfvdpeanlvvavltnrdppnedaaedar 323
                     ++ ++G  ggy++ v+++p  +++v+ l +rd ++++ a + +
      EFC39607.1 334 AIMKSGliGGYNAQVVMIPHCEMAVITLLSRDDGAQSLALQSA 376
                     999999**************************99888776655 PP

  == domain 2  score: 92.1 bits;  conditional E-value: 8.8e-30
                     EEEEETT.EEEEEEEEEEEETTTTEEESTTSBEEEGGGHHHHHHHHHHHHHHTTSS.CTTSBGGGTST....TCTTGGGTTEBHHHHHTTHSSCS CS
  Beta-lactamase  19 vavvrdg.kvvldkggGvadleggrpvtadtlfriaSvtKtftaaavlqlveeGkl.dLddpVskylP....efagpgkgkiTlrdLltHtsGlp 107
                     + v  +g +v++++  G          t  t f i+ +t +ft++a+l   e+G++ +Lddp+ kylP    +   p ++++T+r+L++H sGlp
      EFC39607.1 553 IQVNYKGqQVIMFTF-G--------SSTDSTSFNIGTLTQLFTSTAILIAKEKGLIkSLDDPIVKYLPqivyQENLPFENNMTIRQLMNHASGLP 638
                     555555505555555.6........9****************************9857**************666667777*************9 PP

                     SSSTSTTCTSHHHTH.HHHHHHHHHSBSSSSTTSCEE-SHHHHHHHHHHHHHHHT.SHHHHHHHHHTTTTTTSTTEESSTTGGGGGGBEEEEEEE CS
  Beta-lactamase 108 dlfasdlleeaaada.aellralatlppkyapGtkwgYsntgygllgellekvtg.rsleqllreeilrpLgmkdtelgppesgdprdaagytgn 200
                        + d++++   ++ + + + +a+++   +  t ++ s +g+++lg+l++ ++g  s+ q+++++il+pL+m+d ++++++      a+ +   
      EFC39607.1 639 IIAPCDDTDTCSLNWnQYVEKTMAEQHIIQPSSTLRTFSTIGFSILGRLIASLKGvVSFNQFVTDNILTPLKMTDSGFKSASFL----ASNS--- 726
                     99999999999999988888888999999999999*********************************************7777....4444... PP

                     TCEEECSCETTHHHHCTTTBEEEEHHHHHHHH.........HHHHHCCSSSSHHHHHHHHHHHTSEEEECTTEEEECECSSEEEEECCHTEEEEE CS
  Beta-lactamase 201 gpearappanlpaeaegagglistardlarfl.........glalegglllsaetlaqltaklssgttrpagiraglglGwvladktgapgtfgh 286
                                         ++s++rd+ +fl            +++++      ++ l+  +  +   ++  ++     w+ +++++       
      EFC39607.1 727 -------------------EMYSSIRDVSKFLncisgihreCSIIKKESSRLLHLRNLLSNDKAMSMSLGSFEHEFSNGIWFASKYGSI------ 796
                     ...................469************9866664222222222222333333333333333333333332334555555555...... PP

                     EESTEEEEEEEECGGTEEEEEEESBCSS CS
  Beta-lactamase 287 tGggygtyvfvdpeanlvvavltnrdpp 314
                        gy++yv+++ + +l v+vl+++d +
      EFC39607.1 797 --KGYSSYVAMNDDLDLSVVVLSSSDNN 822
                     ..89*******************99986 PP

>> DUF4715  Domain of unknown function (DUF4715)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   2.2e-05     0.099      11      75 ..     700     762 ..     695     780 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 2.2e-05
     DUF4715  11 lvkvntlqgkkmvesglqsgdfslseslssclpsqadleillqkvagvqreledfkkealkaihr 75 
                 +v+ n l   km +sg++s  f  s+  s    s  d+ ++l+ ++g+ re   +kke+ + +h 
  EFC39607.1 700 FVTDNILTPLKMTDSGFKSASFLASN--SEMYSSIRDVSKFLNCISGIHRECSIIKKESSRLLHL 762
                 6888999*************997665..5778899***********************9988884 PP

>> Beta-lactamase2  Beta-lactamase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0    0.0038        17      12      44 ..      87     119 ..      85     120 .. 0.90
   2 ?    1.7   0.0     0.038   1.7e+02      91     167 ..     230     308 ..     228     321 .. 0.75
   3 ?    1.7   0.0     0.038   1.7e+02     146     189 ..     752     804 ..     708     816 .. 0.66

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0038
                      TS-EE-GGGGHHHHHHHHHHHHHCTSTGTT-EE CS
  Beta-lactamase2  12 deefpaaStiKvpillalleavlegklslderl 44 
                      d+++  aS+ K ++ +a+++  +eg ++ld+ +
       EFC39607.1  87 DTKYRIASVTKTFVSAAMMALRDEGLIDLDQSV 119
                      78999**********888888889******986 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.038
                      HTHHHHHHHHHHCTHTTSB--SHTTCCHHHTTSS.TTEE-HHHHHHHHHHHHHT..TSSHHHHHHHHHHT-STTTTTTTT CS
  Beta-lactamase2  91 lgleavnawlkelglretrlrrklpdleaadkdk.rntttardlarllealarg..ellspeelleilsnqqfrdrlaag 167
                      + ++++n+++ + g++e + + + +++  + +     +++ +dl+   + l++   ++ ++    +i+s+q+ r+ l a+
       EFC39607.1 230 VNKDNLNNLILAEGYHESERIYTNNKTISWSQPAaGMYSSIADLTLYVKNLMNAfaNYGNK-METSIMSRQTLREFLNAQ 308
                      67899999999999999988888777765555542458999***********974333333.34567*******999876 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.038
                      SHHH.....HHHHHHHT-STTTTTTTTTT....TTSEEEEEEEEETTEEEEEE CS
  Beta-lactamase2 146 lspe.....elleilsnqqfrdrlaaglp....egvrvahKtGeldgvrhdvG 189
                      +++e     +l+++lsn +  ++    ++     g+++a+K G+++g  + v+
       EFC39607.1 752 IKKEssrllHLRNLLSNDKAMSMSLGSFEhefsNGIWFASKYGSIKGYSSYVA 804
                      44445544555555665444444433333444499*********999776665 PP

>> FAM194  FAM194 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.1     4e-05      0.18     125     187 ..     553     613 ..     550     630 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 4e-05
      FAM194 125 ikvrilsqdkivitFlalkesaklnvGtklklidpseklsklskaelllaelkkriqklldkl 187
                 i+v+ ++q+ i++tF + + s ++n+Gt ++l ++  +   + k++ l+++l   i k l ++
  EFC39607.1 553 IQVNYKGQQVIMFTFGSSTDSTSFNIGTLTQLFTS--TAILIAKEKGLIKSLDDPIVKYLPQI 613
                 89999*************************99995..44444455566777666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (963 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       644  (0.0359195); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.80u 0.34s 00:00:01.14 Elapsed: 00:00:00.53
# Mc/sec: 5433.85
//
Query:       EFC39608.1  [L=396]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.8e-37  127.1   0.1    8.7e-32  110.0   0.2    3.3  2  Arf        ADP-ribosylation factor family
    1.5e-08   34.9   0.0    4.2e-08   33.4   0.0    1.7  1  Roc        Ras of Complex, Roc, domain of DAPkinase
    1.7e-07   30.8   2.3    5.9e-07   29.0   0.2    2.5  2  G-alpha    G-protein alpha subunit
    3.2e-05   23.4   0.3    0.00047   19.6   0.3    2.1  1  Gtr1_RagA  Gtr1/RagA G protein conserved region
    5.1e-05   22.9   0.0    9.8e-05   22.0   0.0    1.5  1  Ras        Ras family
     0.0014   18.1   0.1      0.022   14.2   0.1    2.3  2  SRPRB      Signal recognition particle receptor beta subunit
  ------ inclusion threshold ------
      0.016   15.3   0.0      0.031   14.3   0.0    1.4  1  MMR_HSR1   50S ribosome-binding GTPase


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  110.0   0.2   3.4e-35   8.7e-32      16     135 ..      16     121 ..       5     134 .. 0.91
   2 !    9.9   0.0   0.00019      0.48     147     174 ..     346     373 ..     319     374 .. 0.82

  Alignments for each domain:
  == domain 1  score: 110.0 bits;  conditional E-value: 3.4e-35
                 EEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHHHHHHHCTSGCCT CS
         Arf  16 rilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeakeeLkalleeeelk 114
                 r+lllGLD++GKt              + Tig+nve+++  +++++++DvGG++++R+lW++Y+++ +a+ifv+Ds++ +Rl+ea++eL++ll++e+l+
  EFC39608.1  16 RVLLLGLDGSGKT--------------INTIGYNVETIKCGKYELNIFDVGGKKHIRSLWNCYYDNNQAIIFVIDSSEPTRLREARRELRKLLSDERLS 100
                 6777777777775..............68********************************************************************** PP

                 TSEEEEEEE-TTSTTSS-HHH CS
         Arf 115 evallvlaNKqDlpealseee 135
                 + ++l++ NK D  +a+s++ 
  EFC39608.1 101 HLPFLIMINKVDCCKAMSHTS 121
                 *****************9875 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00019
                 SSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 147 gkrkleiqkcsavkgeglkeglewlses 174
                 gk++ ++q c+a+ g g+ +g+ w++++
  EFC39608.1 346 GKKQYHLQPCCALDGGGIMQGFAWMCSY 373
                 6899********************9876 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.4   0.0   1.7e-11   4.2e-08      33     119 ..      21     112 ..       9     113 .. 0.74

  Alignments for each domain:
  == domain 1  score: 33.4 bits;  conditional E-value: 1.7e-11
                 TEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHHHCHHHHHHHHHHHCSSS.....-EEEEEE-TT CS
         Roc  33 gvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrssenlkeWlkelkkvagks.....pvilvgnkiD 119
                 g+d + k++++i    ++ k  k++lni+D++G++++rsl ++y+ +++++i+v+ds++ ++l+e  +el+k  +++     p+++++nk+D
  EFC39608.1  21 GLDGSGKTINTIGYNVETIKCGKYELNIFDVGGKKHIRSLWNCYYDNNQAIIFVIDSSEPTRLREARRELRKLLSDErlshlPFLIMINKVD 112
                 5566666665554333344556799*******************************999888888777777765433222337889999999 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1     0.063   1.6e+02      24      37 ..      13      28 ..       3      29 .. 0.76
   2 !   29.0   0.2   2.3e-10   5.9e-07     187     281 ..      30     113 ..      26     129 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.063
                E..EEEEEESTTSSHH CS
     G-alpha 24 v..kllllGqseSGKs 37
                v  ++lllG ++SGK+
  EFC39608.1 13 VpkRVLLLGLDGSGKT 28
                2449***********8 PP

  == domain 2  score: 29.0 bits;  conditional E-value: 2.3e-10
                 ---SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHH CS
     G-alpha 187 ktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDi 281
                  t+G +  +++++ k+e++i+dvgG++  r  W+ ++d+ +aiiF++           +++ +rl+e+ +  +++++ + l + p++++ nK+D 
  EFC39608.1  30 NTIGYNVETIKCG-KYELNIFDVGGKKHIRSLWNCYYDNNQAIIFVID----------SSEPTRLREARRELRKLLSDERLSHLPFLIMINKVDC 113
                 4666666666668.9*******************************87..........44468999999999********************997 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.6   0.3   1.8e-07   0.00047      33     132 ..      30     122 ..       6     132 .. 0.76

  Alignments for each domain:
  == domain 1  score: 19.6 bits;  conditional E-value: 1.8e-07
   Gtr1_RagA  33 atidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletlkeilealrqyspeakvfvlihKmDliqedere 130
                  ti  + ++++  g+ +ln++D+gG++++         ++ + n +++i+V+D+++   l+e+ ++l+++l+   +   ++ + ++i+K+D  + + ++
  EFC39608.1  30 NTIGYNVETIK-CGKYELNIFDVGGKKHIRSL-----WNCYYDNNQAIIFVIDSSEPTrLREARRELRKLLSD--ERLSHLPFLIMINKVDCCKAMSHT 120
                 35666777774.7999*********9987655.....58899999*********9764488888899988875..5567899*********99988776 PP

   Gtr1_RagA 131 ei 132
                 + 
  EFC39608.1 121 SS 122
                 65 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0   3.8e-08   9.8e-05      42     118 ..      38     115 ..      17     152 .. 0.82

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 3.8e-08
                 EETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHHST.TTSEEEEEEETTTGGG CS
         Ras  42 evdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrvae.envpivLvGnKvDlee 118
                 +++  +++l+i+D  G+ + +sl + yy + ++i+ v d ++ + ++++++ ++++ +  + +++p++++ nKvD  +
  EFC39608.1  38 TIKCGKYELNIFDVGGKKHIRSLWNCYYDNNQAIIFVIDSSEPTRLREARRELRKLLSDERlSHLPFLIMINKVDCCK 115
                 34556899******************************************77777666665689***********987 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.1     0.056   1.4e+02       4      17 ..      15      28 ..      13      38 .. 0.91
   2 !   14.2   0.1   8.8e-06     0.022      47     129 ..      42     118 ..      20     162 .. 0.84

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.056
                -EEEEE-STTSSHH CS
       SRPRB  4 pavllvGlsdsGKT 17
                ++vll+Gl  sGKT
  EFC39608.1 15 KRVLLLGLDGSGKT 28
                589**********9 PP

  == domain 2  score: 14.2 bits;  conditional E-value: 8.8e-06
                 GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHHHHHHHHHHHHTT---EEEEEE-TTSTT--- CS
       SRPRB  47 kgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEllyeilliteklkdavdiliACnKqelflaks 129
                  + +l++ D+ G++++r+ l +   + ++ ++++fv+DS+ +p +++e    l ++l++      ++++li  nK +   a s
  EFC39608.1  42 GKYELNIFDVGGKKHIRS-LWNC--YYDNNQAIIFVIDSS-EPTRLREARRELRKLLSDER--LSHLPFLIMINKVDCCKAMS 118
                 456789999999999996.6666..678889********8.78999**9999******998..56788999999999877655 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   1.2e-05     0.031      12     114 .]       5     110 ..       3     110 .. 0.67

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.2e-05
                 HHHHHHHHHTSTE..EESSSTTSSSSEEEEEEE...ETTEEEEEEECGGCSSHHHHHH.HHHHHHHHHHCTSEEEEEEETT.TTCSHHHHHHHHHHHHH CS
    MMR_HSR1  12 KStLinaltgeka..ivsdkpgtTrdinegrvk...lkgkeielvDtpGliegaseek.glgkaflaleeadlillvvdas.eeklkpldeeleellee 103
                 KS +++ ++ +++     d  g+T++++ ++v+    ++ e+++ D+ G  + ++    +l + + +++  ++i++v+d+s  + l++ ++el +ll++
  EFC39608.1   5 KSKVFREIVPKRVllLGLDGSGKTINTIGYNVEtikCGKYELNIFDVGG--K-KH--IrSLWNCYYDNN--QAIIFVIDSSePTRLREARRELRKLLSD 96 
                 66666666666442122455677777766666654366799********..3.22..235777777644..69******77522678888888888866 PP

                 ...TTSEEEEEEES CS
    MMR_HSR1 104 ...akkplilvlnk 114
                    ++ p+++++nk
  EFC39608.1  97 erlSHLPFLIMINK 110
                 77888899999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (396 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       736  (0.0410508); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 2570.53
//
Query:       EFC39609.1  [L=543]
Description: hypothetical protein NAEGRDRAFT_81259 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (543 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       775  (0.0432261); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.46
# Mc/sec: 3560.51
//
Query:       EFC39610.1  [L=808]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.8e-54  183.0   0.2    1.6e-53  182.0   0.2    1.5  1  Peptidase_M60  Peptidase M60, enhancin and enhancin-like
  ------ inclusion threshold ------
      0.049   13.5   3.7      0.057   13.3   0.5    2.3  2  DUF4493        Domain of unknown function (DUF4493)


Domain annotation for each model (and alignments):
>> Peptidase_M60  Peptidase M60, enhancin and enhancin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  182.0   0.2   1.8e-57   1.6e-53      14     270 .]     348     595 ..     344     595 .. 0.91

  Alignments for each domain:
  == domain 1  score: 182.0 bits;  conditional E-value: 1.8e-57
  Peptidase_M60  14 teeeWketlenskapvaelvgkrviltvpteslkklsevdveellklydrvvelvnevagldkrsgapkervkapvrlvadrqisaGfahagypst 109
                    ++++Wk+t++n+++p++e++++++++ v++  +++l+e   + +++ + +v+el++e+++++          ++++r+++d+ is+G++h+gyp++
     EFC39610.1 348 ADSDWKNTIRNYPGPWVEVESDYFVFNVESSYARNLTE--LTSVTNYWKKVLELYYELSQRP--------IRDYKERMQIDIDISIGYMHSGYPIM 433
                    589***********************************..8********************8........5668899999**************** PP

  Peptidase_M60 110 afppssksel..lnvedl....rksg.WgllHElGHnqQvrpgwkwvggttEvtnNvlslyvqekltgidsrrkvsitgadeaanglkgwaretna 198
                    af+++   ++  +n+  +    ++ g Wg++HElGHn+Q    w++++ + Evt+N++sly +e + ++ +++ +s++++++ +++ kg++++ + 
     EFC39610.1 434 AFQDQNEGTIkaVNPANMalasKTPGrWGHYHELGHNFQ-VSDWTYSQ-AVEVTCNIFSLYLEENFPDSANTYGKSFNPPRGLETTFKGNTQDYKG 527
                    **44444333113333322222577**************.788*9999.*********************************************** PP

  Peptidase_M60 199 keylekgkdlLvffgqlklyfgwdfykklleaarkqetlteenkegdkqdefmkkasklakkdLtdFFekwg 270
                    +++ ++    L f+++l ++fgw  ++k + ++ +    t + +e +k d+++ + sk+++++L +F+++w+
     EFC39610.1 528 DWTSAG----LLFYLDLIQAFGWVSIRKAFAEYYTAASGTLPTSEDEKRDQWVVRYSKIVGRNLGPFCDAWS 595
                    **8888....***************************9999999999************************6 PP

>> DUF4493  Domain of unknown function (DUF4493)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.1     0.073   6.5e+02     127     168 ..     225     269 ..     218     301 .. 0.70
   2 ?   13.3   0.5   6.3e-06     0.057     154     210 ..     688     746 ..     645     760 .. 0.90

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.073
     DUF4493 127 vtvstga..ggsltfdktetrk.agYfkageesstltvtlkgtkk 168
                 v++ t+   g++++ + ++ ++  +Yfk+++ ++t+++  ++ ++
  EFC39610.1 225 VSFYTAYfeGSPFVASTKDLSEvNAYFKLEQIQNTFSLYGNVSTD 269
                 555555555666777777777789******766666666666333 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 6.3e-06
     DUF4493 154 eesstltvtlkgtkkngktvtketeeittvkagdhykltlkvke.detgslgititv.d 210
                 +++++l+ t  +t++ng ++t  t++++ vk g+ +k+++++k+ ++ gs++ +i++ d
  EFC39610.1 688 DGTTSLNSTAVVTNNNGTSITLSTNVVEFVKSGQLLKFSFQAKNsVKIGSFTTSIKIlD 746
                 578999999999*******************************9988999999999955 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (808 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       710  (0.0396006); expected 358.6 (0.02)
Passed bias filter:                      467  (0.0260472); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.77u 0.33s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 4597.72
//
Query:       EFC39611.1  [L=1515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      4e-77  255.1 131.1    2.9e-12   47.2   5.2   13.8 12  Big_9       Bacterial Ig domain
    1.4e-42  144.2 104.8    6.2e-10   39.6   4.2   12.9 11  Cadherin_4  Bacterial cadherin-like domain
    4.6e-22   77.8  73.1    8.6e-06   25.6   1.9   13.6 13  Cadherin_5  Cadherin-like domain
    3.9e-13   50.0   0.0    1.2e-12   48.4   0.0    1.9  1  VWA         von Willebrand factor type A domain
    3.7e-10   40.4   0.0      1e-09   39.0   0.0    1.8  1  VWA_2       von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> Big_9  Bacterial Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.7   0.7   1.7e-13     6e-10      14      87 ..      51     125 ..      40     127 .. 0.86
   2 !   43.2   3.9   1.4e-14     5e-11       1      89 [.     129     233 ..     129     234 .. 0.83
   3 !   46.0   5.6   1.9e-15   6.7e-12       1      89 [.     235     324 ..     235     325 .. 0.89
   4 !   15.4   5.4   6.8e-06     0.024       3      89 ..     328     437 ..     326     438 .. 0.79
   5 !   37.5   4.4   8.3e-13     3e-09       5      89 ..     443     534 ..     441     535 .. 0.88
   6 !   47.2   5.2     8e-16   2.9e-12       3      88 ..     548     649 ..     547     650 .. 0.87
   7 !    5.5   0.7    0.0078        28      67      89 ..     658     680 ..     651     681 .. 0.83
   8 !   14.7   9.2   1.1e-05     0.039       5      88 ..     686     835 ..     684     837 .. 0.80
   9 !    8.0   6.0    0.0013       4.6       1      69 [.     838     916 ..     838     925 .. 0.69
  10 !   21.2   5.3   9.9e-08   0.00036       3      89 ..     928    1011 ..     926    1012 .. 0.81
  11 !   15.1   1.6   8.1e-06     0.029       3      89 ..    1016    1108 ..    1014    1109 .. 0.72
  12 !   18.7   0.5   6.2e-07    0.0022       3      86 ..    1115    1210 ..    1113    1214 .. 0.86

  Alignments for each domain:
  == domain 1  score: 39.7 bits;  conditional E-value: 1.7e-13
       Big_9  14 aPvavddsvtvt.....edsvlandtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsD 87 
                  P  ++d +t+      + +vl nd dp g +lt+t+    +v++p++Gtv i +  +++y+   +fsg+d+f+Y vs+
  EFC39611.1  51 SPQPQPDFATTYkrvpiTVDVLINDNDPRGGNLTLTQ----IVDQPKYGTVKILSRSQVVYQSIGSFSGNDTFSYEVSN 125
                 67777888888766656667799**********9775....69**********************************97 PP

  == domain 2  score: 43.2 bits;  conditional E-value: 1.4e-14
       Big_9   1 tatvtvtvtpvndaPvavdds..vtvtedsv...........landtdpdgdaltvtsltvtlvta...panGtvtinadgtltytpnagfsgtdsftY 83 
                 ta++tvtv+  n++P av+    ++ +++ +            +  td+d+d l vt +  ++vt+   ++ G ++i++ + + ytp +gf+g ++f+Y
  EFC39611.1 129 TANATVTVQVLNRPPQAVPIYkkISKNANKAlvdifnyigdnDEKITDIDNDVLYVTGFADQQVTSgnaQSLGAIEIDPYNGFLYTPVNGFNGIEQFKY 227
                 78999999999********884444445555555555544433489***********99888888888899**************************** PP

       Big_9  84 tvsDgs 89 
                 t+sDg+
  EFC39611.1 228 TISDGN 233
                 ****97 PP

  == domain 3  score: 46.0 bits;  conditional E-value: 1.9e-15
       Big_9   1 tatvtvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpna..gfsgtdsftYtvsDgs 89 
                 ta+ tvtv+ +ndaPva+dd + +++ s+     l+nd d++gd+ +     vt + ++++G + +  d t++y  ++      tdsf+Y++sD++
  EFC39611.1 235 TASSTVTVEVENDAPVATDDVYRIPKYSSlelliLQNDYDINGDDFN-----VTNAVGAGYGALRVQ-DKTVVYFTSSvlTKKYTDSFEYSISDSQ 324
                 78999999999**************99888888899*********86.....566789*********.66877777777999************86 PP

  == domain 4  score: 15.4 bits;  conditional E-value: 6.8e-06
       Big_9   3 tvtvtvtpvndaPvavddsvtvtedsv...la.ndtdpdgdaltvtsltvtlvta........................panGtvtinadgtltytpna 73 
                 ++ v v+  n+ P++ + +vtv + s+   ++   +dpdg +     +++t vt+                         +  +v+ n + t++ytp++
  EFC39611.1 328 SAVVSVQVYNTEPTVYSKTVTVGKSSSnnlISiDYSDPDGKDV----VVLTKVTPalaslnpaasmqvakgtkrvnldcCDWVSVETN-NYTIVYTPTP 421
                 556677777*************96666555444889*****98....56778888889999999999999999999955444445544.668******* PP

       Big_9  74 gfsgtdsftYtvsDgs 89 
                 g   + +++++ +Dg+
  EFC39611.1 422 GVVYSQTLDISMTDGE 437
                 **************96 PP

  == domain 5  score: 37.5 bits;  conditional E-value: 8.3e-13
       Big_9   5 tvtvtpvndaPvavddsvtvtedsv.....landtdpdgdaltvtsltvtlvta..panGtvtinadgtltytpnagfsgtdsftYtvsDgs 89 
                 ++t++ vn +Pvavdd+vt ++++      land d++  + ++ +lt ++ ++   ++G+v+i +   + y +++g   td  +Y++ D s
  EFC39611.1 443 KITINVVNNPPVAVDDTVTCNKNQQvlinvLANDYDVNPGDTELLQLTNNGWQSttKNGGSVSIYNATHVLYVAPKGSLATDVASYRIYDQS 534
                 589999**************9777778888*******998888888877654445599*******999********************9975 PP

  == domain 6  score: 47.2 bits;  conditional E-value: 8e-16
       Big_9   3 tvtvtvtpvndaPvavddsvtvt.....edsvlandtdpdgdaltvtsltvtlvta................panGtvtinadgtltytpnagfsgtds 80 
                 t ++ ++ +n +Pv vdd +t++     + +vl+nd dp+ d ++    t+++v+                 p+nG v++ +d +++ytpn+ f g d+
  EFC39611.1 548 TGKISINIINNPPVPVDDVFTISkglnaTLNVLNNDYDPNFDLIS----TINSVDRstvknilatiieiyqnPSNGVVEVISD-SVRYTPNTAFVGVDT 641
                 557888889*************9888766777*********9986....334444445789********************99.*************** PP

       Big_9  81 ftYtvsDg 88 
                 f+Y+ +Dg
  EFC39611.1 642 FQYKLNDG 649
                 *******8 PP

  == domain 7  score: 5.5 bits;  conditional E-value: 0.0078
       Big_9  67 ltytpnagfsgtdsftYtvsDgs 89 
                 ++ t ++   gt +++YtvsDg+
  EFC39611.1 658 FVSTQTSATVGTKQIKYTVSDGN 680
                 5667778899***********97 PP

  == domain 8  score: 14.7 bits;  conditional E-value: 1.1e-05
       Big_9   5 tvtvtpvndaPvavddsvtvt......edsvlandtdpdgdaltvtsltvtlvta............................................ 53 
                 +v+v  +n++Pva +d++t +      + sv +nd d+d d+++++s++ ++++                                             
  EFC39611.1 686 NVNVLVTNTKPVAFADAYTYHwaapkqTLSVMSNDKDADLDPISIKSVSGSAAAVkngndidytpkkdvvygkwnspvsvslanvcsdidtldipyvaf 784
                 5788889**********9999777655555599***********9998655544488888888888888888888888888888888888888888888 PP

       Big_9  54 ......panGtvtinadgtltytpna...........gfsgtdsftYtvsDg 88 
                        a+G+ +++++ t+t+tp+             ++ t+sf+++  Dg
  EFC39611.1 785 ngvisnVAGGSTSLSGT-TVTFTPSVtslvftqisgnLYNATASFKFQCFDG 835
                 88888888888888876.8888888888888888888788888888877776 PP

  == domain 9  score: 8.0 bits;  conditional E-value: 0.0013
       Big_9   1 tatvtvtvtpvndaPvavddsvtvtedsv.............landtdpdgdaltvtsltvtlvtapanGtvtinadgtlty 69 
                 t+t +vt+   n aP+ +  +v+++ d +              an  d+dgd+ t+t+l+   v+++     t++++ ++t+
  EFC39611.1 838 TSTGNVTIILSNNAPTGTGKTVNIARDYTkttydftwseiatYANP-DVDGDSVTITNLVS--VDSSITVEQTVSGTKQITF 916
                 67888999999**********8888555545566666665535566.9********98744..4444444444455556776 PP

  == domain 10  score: 21.2 bits;  conditional E-value: 9.9e-08
       Big_9    3 tvtvtvtpvndaPvavdds.vtvtedsv..la...ndtdpdgdaltvtsltvtlvtapanGtvtinadgtltytpnagfsgtdsftYtvsDgs 89  
                  ++t+tv   n aP+    s + +++ ++  l+   + td ++d++t   +t++  ++++ Gt++ +     ++t++a  +gt++f+Yt++D++
  EFC39611.1  928 KLTFTVIFSNSAPTCGVVStIYLNKKGSvdLStkfSGTDSNNDPIT---FTLS-GSPGSLGTLSGK-----VFTASATNTGTVTFSYTATDTQ 1011
                  68999999*******997756666555536446679999*****98...5554.678999999988.....9*******************85 PP

  == domain 11  score: 15.1 bits;  conditional E-value: 8.1e-06
       Big_9    3 tvtvtvtpvndaPvavddsvtvt..edsv...la.ndtdpdgdaltvtsltvtlvtapanGtvtin.adgtltytpna.gfsgtdsftYtvsDgs 89  
                  + ++++  +n +P a+d+ + +   +ds+   l+  +td+dgd+lt+t+ +    + +    v++n a+g +t+       sgt   +++vsD++
  EFC39611.1 1016 SCSIQIIIQNANPSANDTIFYIYptADSLshyLSyKATDADGDTLTYTAGSN-NCS-SISTGVSMNsASGLITFKRIYtVVSGTCKMSVSVSDSN 1108
                  668899999**********7774436666777558**********9886532.333.44444666658889998754437889999999999986 PP

  == domain 12  score: 18.7 bits;  conditional E-value: 6.2e-07
       Big_9    3 tvtvtvtpvndaPvavddsvtvtedsv........landtdpdgdaltvtsltvtlvta....panGtvtinadgtltytpnagfsgtdsftYtvs 86  
                  ++t+t   v   Pva dd ++++++++        land d  g++ t+t l+++  +a     +   vt+n+   +  + +++    d f Yt +
  EFC39611.1 1115 NATITFVIVPIDPVARDDRFSIPQGQTirifasqiLANDNDELGTSSTLTLLNISCPDAtychKQPRFVTVNDEIAVEVDSDQNTCQADKFRYTMT 1210
                  567777778889***********999999999999************9998877766669999777889999888899999999999999999988 PP

>> Cadherin_4  Bacterial cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.4   0.3   4.7e-09   1.7e-05      13      66 ..      51     101 ..      41     121 .. 0.85
   2 !    9.3   1.6   0.00048       1.7       1      57 [.     130     191 ..     130     214 .. 0.63
   3 !   35.7   2.3   2.8e-12     1e-08       1      66 [.     236     297 ..     236     304 .. 0.90
   4 !    5.4   1.5    0.0078        28       4      54 ..     330     377 ..     327     417 .. 0.74
   5 !   39.6   4.2   1.7e-13   6.2e-10       5      64 ..     444     506 ..     442     520 .. 0.78
   6 !   19.7   7.4   2.7e-07   0.00096       2      64 ..     548     623 ..     547     674 .. 0.84
   7 !   16.8   5.6   2.2e-06     0.008       4      57 ..     686     737 ..     685     821 .. 0.88
   8 ?    3.1   7.5      0.04   1.4e+02       2      53 ..     840     895 ..     839     915 .. 0.68
   9 !    5.7   2.4    0.0064        23       2      72 .]     928    1003 ..     927    1006 .. 0.71
  10 !   13.3   0.1   2.8e-05       0.1       4      54 ..    1018    1066 ..    1015    1089 .. 0.75
  11 !   21.0   0.9   1.1e-07   0.00039       3      54 ..    1116    1167 ..    1114    1198 .. 0.86

  Alignments for each domain:
  == domain 1  score: 25.4 bits;  conditional E-value: 4.7e-09
  Cadherin_4  13 aPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlna 66 
                 +P  ++d at+    p+t+   +vl nd+D+ g+ lt t++  ++ yGt+ + +
  EFC39611.1  51 SPQPQPDFATTYKRVPITV---DVLINDNDPRGGNLTLTQIVDQPKYGTVKILS 101
                 68889999***********...9*****************999******77655 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00048
  Cadherin_4   1 atvtitvtgvndaPvavdd..satvtedtpltitagnvl....andtDvdgddltvtavtvag 57 
                 a++t+tv+  n +P av+    ++ + + +l+    n +    +  tD+d+d l vt+++ + 
  EFC39611.1 130 ANATVTVQVLNRPPQAVPIykKISKNANKALVD-IFNYIgdndEKITDIDNDVLYVTGFADQQ 191
                 6899*************9621455566666653.3455553336679**********997322 PP

  == domain 3  score: 35.7 bits;  conditional E-value: 2.8e-12
  Cadherin_4   1 atvtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGtltlna 66 
                 a+ t+tv+  ndaPva+dd++ ++  ++l      +l nd+D++gdd+ vt +   + yG l +++
  EFC39611.1 236 ASSTVTVEVENDAPVATDDVYRIPKYSSLEL---LILQNDYDINGDDFNVTNAV-GAGYGALRVQD 297
                 5679***************************...79**************9986.56799998865 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.0078
  Cadherin_4   4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd.ltvtavt 54 
                  ++v+  n  P++   ++tv   ++ +     +  + +D+dg d +  t vt
  EFC39611.1 330 VVSVQVYNTEPTVYSKTVTVGKSSSNNL----ISIDYSDPDGKDvVVLTKVT 377
                 6788888999999999999998888777....556779****9966668887 PP

  == domain 5  score: 39.6 bits;  conditional E-value: 1.7e-13
  Cadherin_4   5 itvtgvndaPvavddsatvtedtpltitagnvlandtDvd.gdd..ltvtavt...vagtyGtltl 64 
                 it++ vn++Pvavdd++t++ ++++ i   nvland+Dv+ gd+  l+ t      ++ ++G++++
  EFC39611.1 444 ITINVVNNPPVAVDDTVTCNKNQQVLI---NVLANDYDVNpGDTelLQLTNNGwqsTTKNGGSVSI 506
                 9**************************...**********54446644443323234567788776 PP

  == domain 6  score: 19.7 bits;  conditional E-value: 2.7e-07
  Cadherin_4   2 tvtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgdd.ltvtavt...............vagtyGtltl 64 
                 t  i+++  n++Pv vdd++t+  +  +t    nvl+nd+D++ d   t+++v+                ++++G + +
  EFC39611.1 548 TGKISINIINNPPVPVDDVFTISKGLNATL---NVLNNDYDPNFDLiSTINSVDrstvknilatiieiyQNPSNGVVEV 623
                 66899*************************...9********9988556666654445555555555445667777665 PP

  == domain 7  score: 16.8 bits;  conditional E-value: 2.2e-06
  Cadherin_4   4 titvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavtvag 57 
                 +++v  +n  Pva +d++t    +p ++   +v +nd D+d d++++++v++++
  EFC39611.1 686 NVNVLVTNTKPVAFADAYTYHWAAPKQT--LSVMSNDKDADLDPISIKSVSGSA 737
                 589999************9877777766..477*****************9654 PP

  == domain 8  score: 3.1 bits;  conditional E-value: 0.04
  Cadherin_4   2 tvtitvtgvndaPvavddsatvtedtplt...itagnvl.andtDvdgddltvtav 53 
                 t ++t+   n+aP+ +  +++++ d + t   +t   +      Dvdgd++t+t +
  EFC39611.1 840 TGNVTIILSNNAPTGTGKTVNIARDYTKTtydFTWSEIAtYANPDVDGDSVTITNL 895
                 6789*****************99974444233433333323345899999999875 PP

  == domain 9  score: 5.7 bits;  conditional E-value: 0.0064
  Cadherin_4    2 tvtitvtgvndaPv.avddsatvtedtpltitagnvlandtDvdgddltvtavtvagtyGt.......ltlnadGsftY 72  
                  ++t+tv   n aP+  v  ++  +  +++  +        tD ++d++t+t     g+ Gt        +  ++G++t+
  EFC39611.1  928 KLTFTVIFSNSAPTcGVVSTIYLNKKGSVDLS---TKFSGTDSNNDPITFTLSGSPGSLGTlsgkvftASATNTGTVTF 1003
                  589***********888889999999999993...33467888889999988776777775333332244444555554 PP

  == domain 10  score: 13.3 bits;  conditional E-value: 2.8e-05
  Cadherin_4    4 titvtgvndaPvavddsa.tvtedtpltitagnvlandtDvdgddltvtavt 54  
                  +i++  +n +P a+d  +   +  ++l+     +   +tD+dgd+lt+ta +
  EFC39611.1 1018 SIQIIIQNANPSANDTIFyIYPTADSLSH---YLSYKATDADGDTLTYTAGS 1066
                  8999************9835566777777...79999************987 PP

  == domain 11  score: 21.0 bits;  conditional E-value: 1.1e-07
  Cadherin_4    3 vtitvtgvndaPvavddsatvtedtpltitagnvlandtDvdgddltvtavt 54  
                  +tit   v  +Pva dd +++++++++ i a ++land+D  g + t t ++
  EFC39611.1 1116 ATITFVIVPIDPVARDDRFSIPQGQTIRIFASQILANDNDELGTSSTLTLLN 1167
                  7899999999******************************988886655544 PP

>> Cadherin_5  Cadherin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.4   0.2   1.1e-07   0.00038      23      96 ..      68     137 ..      52     139 .. 0.85
   2 !   25.6   1.9   2.4e-09   8.6e-06      33      97 ..     174     244 ..     172     245 .. 0.80
   3 !   12.8   1.2   2.4e-05     0.088       2      94 ..     246     332 ..     245     336 .. 0.70
   4 !    7.6   2.3   0.00099       3.6       1      85 [.     449     534 ..     449     543 .. 0.74
   5 !   11.0   1.0   9.2e-05      0.33      49      88 ..     615     653 ..     557     663 .. 0.73
   6 !    7.1   0.4    0.0015       5.3      61      92 ..     656     686 ..     650     692 .. 0.72
   7 !    7.9   0.1   0.00082       2.9      28      70 ..     715     753 ..     693     767 .. 0.79
   8 ?    0.2   0.1      0.21   7.7e+02      69      92 ..     820     842 ..     762     847 .. 0.74
   9 !    8.1   0.5   0.00072       2.6       2      63 ..     849     912 ..     848     933 .. 0.75
  10 !    7.9   0.2    0.0008       2.9      64      94 ..     990    1020 ..     965    1024 .. 0.82
  11 !    8.8   0.8   0.00043       1.5      31      96 ..    1050    1119 ..    1029    1121 .. 0.81
  12 ?    2.3   0.0     0.047   1.7e+02      15      84 ..    1135    1212 ..    1125    1225 .. 0.64
  13 ?    2.3   0.1     0.046   1.7e+02      54      81 ..    1431    1458 ..    1422    1469 .. 0.86

  Alignments for each domain:
  == domain 1  score: 20.4 bits;  conditional E-value: 1.1e-07
  Cadherin_5  23 titaaqLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttataslt 96 
                 t    ++L n+ D+ g +L+ +++  + + Gtv   +  +++++    ++G+ t+sY+vs     t++at++++
  EFC39611.1  68 T---VDVLINDNDPRGGNLTLTQIVDQPKYGTVKILSRSQVVYQSIGSFSGNDTFSYEVSNSF-VTANATVTVQ 137
                 3...459*****************98999*******************************996.5555555554 PP

  == domain 2  score: 25.6 bits;  conditional E-value: 2.4e-09
  Cadherin_5  33 asDvdgdtLsvsslta.......daenGtvvdngdGtftftpeanynGevtlsYtvsDgeggtttatasltv 97 
                 ++D+d+d L v++ +        +++ G +  +    f +tp + +nG  +++Yt+sDg+  t+++t++++v
  EFC39611.1 174 ITDIDNDVLYVTGFADqqvtsgnAQSLGAIEIDPYNGFLYTPVNGFNGIEQFKYTISDGN-DTASSTVTVEV 244
                 79*********99843455555545567787888888**********************8.77778888776 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 2.4e-05
  Cadherin_5   2 ndaPvvssevtlaagseDtaltitaaqLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpe.anynGevtlsYtvsDgeggtttatas 94 
                 ndaPv++++  + ++ + ++l +    +L+n+ D++gd+ +v++  + a+ G +  +    + ft      + + +++Y++sD ++ + +a +s
  EFC39611.1 246 NDAPVATDD--VYRIPKYSSLELL---ILQNDYDINGDDFNVTNA-VGAGYGALRVQDKTVVYFTSSvLTKKYTDSFEYSISDSQA-SGSAVVS 332
                 777777765..4456666666555...89***************9.577799998866655666665234446789********84.3334444 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.00099
  Cadherin_5   1 vndaPvvssevtlaagseDtaltitaaqLLanasDvd.gdt..Lsvssl...tadaenGtvvdngdGtftftpeanynGevtlsYtvsDge 85 
                 vn+ Pv+ ++  + + ++++++ i+   +Lan+ Dv+ gdt  L+ ++    +++++ G+v   +   + +   +    +   sY++ D +
  EFC39611.1 449 VNNPPVAVDD--TVTCNKNQQVLIN---VLANDYDVNpGDTelLQLTNNgwqSTTKNGGSVSIYNATHVLYVAPKGSLATDVASYRIYDQS 534
                 7999999976..44899999****9...*********999999888775333345556677666656666666666666777789998875 PP

  == domain 5  score: 11.0 bits;  conditional E-value: 9.2e-05
  Cadherin_5  49 daenGtvvdngdGtftftpeanynGevtlsYtvsDgeggt 88 
                 + +nG vv+   +++ +tp++ + G  t++Y+ +Dg   +
  EFC39611.1 615 NPSNG-VVEVISDSVRYTPNTAFVGVDTFQYKLNDGIFDS 653
                 33344.455567789*********************6443 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.0015
  Cadherin_5  61 GtftftpeanynGevtlsYtvsDgeggtttat 92 
                  +f+ t ++   G+ +++YtvsDg+ +t+  +
  EFC39611.1 656 VKFVSTQTSATVGTKQIKYTVSDGNKNTI-GN 686
                 566777778888************95554.44 PP

  == domain 7  score: 7.9 bits;  conditional E-value: 0.00082
  Cadherin_5  28 qLLanasDvdgdtLsvssltadaenGtvvdngdGtftftpean 70 
                 ++++n++D+d d +s++s++   +++  v+ng++ + +tp+++
  EFC39611.1 715 SVMSNDKDADLDPISIKSVS---GSAAAVKNGND-IDYTPKKD 753
                 4789***************5...34566777665.88899887 PP

  == domain 8  score: 0.2 bits;  conditional E-value: 0.21
  Cadherin_5  69 anynGevtlsYtvsDgeggtttat 92 
                 + yn +++++++  Dg ++ +t +
  EFC39611.1 820 NLYNATASFKFQCFDGIST-STGN 842
                 3489999999999999744.3344 PP

  == domain 9  score: 8.1 bits;  conditional E-value: 0.00072
  Cadherin_5   2 ndaPvvsse.vtlaagseDtaltitaaqLLanas.DvdgdtLsvssltadaenGtvvdngdGtf 63 
                 n+aP+ +++ v++a+    t++ +t +++ + a  Dvdgd++++++l   +++ tv +   Gt 
  EFC39611.1 849 NNAPTGTGKtVNIARDYTKTTYDFTWSEIATYANpDVDGDSVTITNLVSVDSSITVEQTVSGTK 912
                 88999998867787778888888998888776544************65554666666666654 PP

  == domain 10  score: 7.9 bits;  conditional E-value: 0.0008
  Cadherin_5   64 tftpeanynGevtlsYtvsDgeggtttatas 94  
                  +ft  a  +G+vt+sYt +D++ ++++ +++
  EFC39611.1  990 VFTASATNTGTVTFSYTATDTQLTSSSCSIQ 1020
                  58999999*************9555554444 PP

  == domain 11  score: 8.8 bits;  conditional E-value: 0.00043
  Cadherin_5   31 anasDvdgdtLsvsslta...daenGtvvdngdGtftftpe.anynGevtlsYtvsDgeggtttataslt 96  
                   +a+D+dgdtL+ ++ +    + ++G  ++ + G +tf+   +  +G+ ++s +vsD ++ + +++a++t
  EFC39611.1 1050 YKATDADGDTLTYTAGSNncsSISTGVSMNSASGLITFKRIyTVVSGTCKMSVSVSDSNTPSGKSNATIT 1119
                  579********997654333355678889999******98725578************998888888776 PP

  == domain 12  score: 2.3 bits;  conditional E-value: 0.047
  Cadherin_5   15 agseDtaltitaaqLLanasDvdgdt..Lsvsslta.....daenGtvv.dngdGtftftpeanynGevtlsYtvsDg 84  
                  ++ +++++ i a+q+Lan+ D  g +  L+  +++       +++  +v  n +  + ++ ++n   + ++ Yt + +
  EFC39611.1 1135 SIPQGQTIRIFASQILANDNDELGTSstLTLLNISCpdatyCHKQPRFVtVNDEIAVEVDSDQNTCQADKFRYTMTTA 1212
                  56678899999**********987654477777765444443444444413444466677777777777777777655 PP

  == domain 13  score: 2.3 bits;  conditional E-value: 0.046
  Cadherin_5   54 tvvdngdGtftftpeanynGevtlsYtv 81  
                  t  +n++G +  +p++ ynG+ +++++v
  EFC39611.1 1431 TWKRNSNGVVPNDPDNPYNGNNKVQWKV 1458
                  556899*****************99998 PP

>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.4   0.0   3.4e-16   1.2e-12       1     116 [.    1235    1346 ..    1235    1353 .. 0.92

  Alignments for each domain:
  == domain 1  score: 48.4 bits;  conditional E-value: 3.4e-16
                  EEEEEEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTGSGGGGSSC-HHHHHHHHHHHHHHHHG CS
         VWA    1 DivfvlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfssevktefslndysskeellsalnnlkysgggttntgkalkyaleklfkssa 97  
                  D vf+lD+S+s+g  nf+ +++  +++ +++++  + ++v++v f s+++    l+++   + +++ l+++ky  g t+    +l +a++ +++ ++
  EFC39611.1 1235 DFVFLLDSSQSIGVPNFNLIRDLCQRITGRMKLADDAVKVSIVRFHSSATLTLALSTDG--SLINKTLSTMKYDAGFTA-QVPGLRAAVN-ALRPEN 1327
                  679******************************************************88..899******999998888.666*****99.677777 PP

                  TSSTTSEEEEEEEESS--C CS
         VWA   98 gaRenakkviilltdGksn 116 
                  g R++a kvi +ltdG  n
  EFC39611.1 1328 GGRADADKVIYILTDGLAN 1346
                  77**************776 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.0   2.9e-13     1e-09       1     106 [.    1236    1343 ..    1236    1344 .. 0.93

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 2.9e-13
       VWA_2    1 lvfvlDtSgSmrngdygptrleaakdaveallksl..pgd..rvglvtfsdgpevlipltkdkakilnalrnleakgggtnlaaaLqlarkalkkrr 93  
                  +vf+lD+S+S++ +     ++  ++d+ +++ +++  ++d  +v++v f +++++ + l++d + i++ l  +++++g t    +L+ a +al+ ++
  EFC39611.1 1236 FVFLLDSSQSIGVP-----NFNLIRDLCQRITGRMklADDavKVSIVRFHSSATLTLALSTDGSLINKTLSTMKYDAGFTAQVPGLRAAVNALRPEN 1327
                  59************.....8*************886633356***************************************************7777 PP

       VWA_2   94 ...kgekrvivlitDg 106 
                     + + +vi+++tDg
  EFC39611.1 1328 ggrADADKVIYILTDG 1343
                  7889***********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       727  (0.0405488); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.91u 0.34s 00:00:01.25 Elapsed: 00:00:00.53
# Mc/sec: 8673.82
//
Query:       EFC39612.1  [L=515]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-85  285.6   2.2    7.7e-85  285.4   2.2    1.0  1  p450      Cytochrome P450


Domain annotation for each model (and alignments):
>> p450  Cytochrome P450
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  285.4   2.2   4.3e-89   7.7e-85      26     461 ..      75     509 ..      52     511 .. 0.88

  Alignments for each domain:
  == domain 1  score: 285.4 bits;  conditional E-value: 4.3e-89
                 HHHHHHHH-SEEEEEETTEEEEEEESHHHHHHHHCTSTTTTCEESSHHHHHHHHHTTTTSSSTTCGHHHHHHHHHHHHHHHTSHSTT.THHHHHHHHHH CS
        p450  26 lrklqkkygpifrlklgskpvvvlsgpeavkevlikkgeefsgrpdeallatsrkpfkgkgvlfangekwkklRrfltptltsfgkl.sleelveeeae 123
                 +++++     ++r+ + + ++v++ + ++ ke +++k+  +s++ ++ ++++  ++f ++ +   + ++wk+++++ +p++  + +l  + e   e+++
  EFC39612.1  75 FDEFSDG-NGVLRMSFVRGNTVMIKNKQMLKEFFVTKQ--SSFE-KPEFIYSMFEMFGQNVLSAPDVSDWKRHHKVAHPAFSID-NLqYMCEEAVECTD 168
                 5555544.357888888999*****************6..5555.4445555454665555555556****************9.8879999999999* PP

                 HHHHHHHCCCCHCS....EEETHHHHHHHHHHHHHHHHHSSHHHTTTSSHHHHHHHHHHHHHHHHHCHHHHCCCCCH.HHTCCSCHHHHHHHHHHHHHH CS
        p450 124 dlveklrkkagess....elditellskaaldvigsilFgarfdlledeklselvkaveelssllskssvqllllfp.llkylptkllrklkeavkklk 217
                  lv+++  +++ +s      +i e +s ++++v+g+  ++++f+ + d+++s ++++ ++++ l+sk      ++ +  ++y +++ l  +++av +++
  EFC39612.1 169 LLVDRWINSHSGKSfelkDDEIGEAMSTVTVEVLGRAGLKVSFG-MFDREDSHAEEFKNAVNLLVSKGLLVQRFFGKnPFLYKWSQRLLGVDKAVSIVN 266
                 *****99999999877777778899*******************.888889999999999999998876433333334777777777788899****** PP

                 HHHHHHHHHHHHCHCHC..SCSSCSHHHHHHHHCTTCTCTSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHCCTTTT-H CS
        p450 218 dlldklieerretldsa..kksrrdfldalllakkekkgesklsdeelaatvlellfaGvdTtsstlswaLyeLaknPevqeklreEidevlgdkrept 314
                  +l++ i +r+++l+s+  + s++d l++l++a    +++ +l+d el+ + l +l+aG +Ttss l+w+LyeLak+Pe+q++ reEi++vl++k +p 
  EFC39612.1 267 RVLNNSIVDRKKELESDfgNFSKKDILSLLVKAN--AEEK-TLTDMELKSNSLIFLLAGEETTSSSLQWVLYELAKHPEYQKRAREEINSVLPNKAKPN 362
                 *******************999***********6..5555.7**************************************************99999** PP

                 HHHCCT-HHHHHHHHHHHHHSCSSTTEEEEESSSCEEETTEEE-TT-EEEEEHHHHHT-TTTSSSTTS--GGGGB-TTS.CTESSCTT--TTEEGGGS- CS
        p450 315 yddlqklpyldavikEtLRlhpvvplllpRevtkdvvirgylipkGtevivnlyalhrdpevfpnPeeFdpeRFldekg.nskrksfaflPFGaGpRnC 412
                 y+ +q lp+++ vi E+LRlhp+v  ++ +++ k+v++++y ipk+t v v++y+++r++e++++Pee++p+RF d +  n+++++f fl F++G R C
  EFC39612.1 363 YETVQALPFTTGVILEALRLHPPVF-SVAKQTVKNVKLGDYEIPKNTLVTVFIYGVNRSKEYWKDPEEYQPDRFMDMELrNKSQHDFTFLSFSMGQRKC 460
                 *************************.**************************************************9999888**************** PP

                 TTHHHHHHHHHHHHHHHHHHEEEEESTSTSGGEEESSCSSEEESSSSEE CS
        p450 413 iGerlArmelklflatlLqnFevelqpetdpppileksglllppkpikl 461
                 iG ++A++e  ++l++lLqnFe++l +++++++    + ++++p ++kl
  EFC39612.1 461 IGFQFAQLEACMILVRLLQNFEFTLLNDESKEKVRAMKNVTIRPANLKL 509
                 **************************99999998888788888888776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (515 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       804  (0.0448435); expected 358.6 (0.02)
Passed bias filter:                      547  (0.0305092); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 3035.73
//
Query:       EFC39613.1  [L=608]
Description: hypothetical protein NAEGRDRAFT_81263 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      2e-09   37.8   3.6    2.8e-09   37.3   0.5    2.3  2  RGS       Regulator of G protein signaling domain
  ------ inclusion threshold ------
        0.2   12.4   0.1        3.8    8.3   0.0    2.3  2  YukD      WXG100 protein secretion system (Wss), protein YukD


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.2     0.012   1.1e+02      32      66 ..     444     478 ..     442     482 .. 0.76
   2 !   37.3   0.5   3.1e-13   2.8e-09       6      98 ..     470     574 ..     465     588 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.012
                 HHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSS CS
         RGS  32 laveefkkakeqeelkkkakeIyneylapsspkel 66 
                   ve++kk+k+++  +k+  +I++ +l ++ +  +
  EFC39613.1 444 AIVEDYKKSKKEKMQTKQELSIVEIFLRNKKTYDI 478
                 569******666666666999******88877666 PP

  == domain 2  score: 37.3 bits;  conditional E-value: 3.1e-13
                 HTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.............STTTTTTH CS
         RGS   6 ledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke.............qpsrklfe 91 
                 l +++   ++ ++ ++++++e ++ w+++++fkk+ +++++ +  k I+n+yl +++p eln++ +lr++    +e++             + s++lfe
  EFC39613.1 470 LRNKKTYDILLDYARRSYCQESVQCWKDIQKFKKS-SKKNRPRVGKFIFNTYLLENAPVELNLPADLRANSIVTIETAlfetnqgtttkskKISKRLFE 567
                 66777888999************************.*********************************999999988999999999999888899999 PP

                 HHHHHHH CS
         RGS  92 eaqeevf 98 
                 e++ ++ 
  EFC39613.1 568 EVELHCV 574
                 8887775 PP

>> YukD  WXG100 protein secretion system (Wss), protein YukD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.0   0.00043       3.8      47      75 ..     132     160 ..     131     160 .. 0.94
   2 ?    1.4   0.0     0.059   5.3e+02       8      28 ..     522     542 ..     519     561 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00043
                 -EEEEGGGEEEETTSBCGGGT--TT-EEE CS
        YukD  47 wsLarvggapLsgdrtLaeagVrDGdlLv 75 
                 ++L + ++++L+g++tL +  + DG +Lv
  EFC39613.1 132 YRLNVETKQVLEGKQTLVQPKIEDGTTLV 160
                 7899999*******************996 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.059
                 -TTTEEEEEEETTSBTTHHHH CS
        YukD   8 agnrrvDlaLPadvpvaellp 28 
                  +n+ v+l LPad+ +  ++ 
  EFC39613.1 522 LENAPVELNLPADLRANSIVT 542
                 578889********9999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (608 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1551  (0.0865079); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 3649.94
//
Query:       EFC39614.1  [L=1048]
Description: Hypothetical protein NAEGRDRAFT_72637 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1048 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2417  (0.13481); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.95u 0.35s 00:00:01.29 Elapsed: 00:00:00.55
# Mc/sec: 5721.85
//
Query:       EFC39615.1  [L=330]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      1e-16   60.8  11.3    2.9e-06   27.4   0.5    6.5  7  PPR_2           PPR repeat family
    1.5e-16   59.8   3.2      4e-07   29.6   0.0    4.7  4  PPR_1           PPR repeat
    6.6e-14   51.1  11.9    3.2e-05   23.9   0.2    6.1  7  PPR             PPR repeat
    7.4e-08   32.0   0.0    1.6e-06   27.7   0.0    2.5  2  PPR_long        Pentacotripeptide-repeat region of PRORP
    0.00047   20.5   1.6    0.00079   19.8   1.1    1.7  1  RPN6_N          26S proteasome regulatory subunit RPN6 N-term
     0.0021   18.1   6.9      0.028   14.5   0.0    4.2  5  PPR_3           Pentatricopeptide repeat domain
  ------ inclusion threshold ------
      0.016   15.0   0.3       0.17   11.8   0.0    2.6  3  ATP13           Mitochondrial ATPase expression
      0.052   12.0   0.0      0.076   11.4   0.0    1.1  1  Hydantoinase_B  Hydantoinase B/oxoprolinase
      0.064   13.8   0.4       0.25   11.9   0.4    2.1  1  EF-G-binding_N  Elongation factor G-binding protein, N-termin
       0.11   12.5   0.0       0.22   11.6   0.0    1.4  1  DUF4427         Protein of unknown function (DUF4427)


Domain annotation for each model (and alignments):
>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1      0.12   2.1e+02      15      37 ..      39      61 ..      35      63 .. 0.78
   2 ?   -2.8   0.0       4.4   7.9e+03      17      32 ..     115     130 ..     106     135 .. 0.80
   3 ?   -2.9   0.0       4.6   8.2e+03       9      28 ..     157     176 ..     155     186 .. 0.78
   4 !   25.1   0.1   8.5e-09   1.5e-05      19      49 ..     218     251 ..     189     252 .. 0.80
   5 !   27.4   0.5   1.6e-09   2.9e-06       1      48 [.     238     286 ..     238     286 .. 0.94
   6 !   14.5   0.0   1.7e-05      0.03       8      28 ..     281     301 ..     274     305 .. 0.91
   7 !   12.7   0.0   6.1e-05      0.11       6      25 ..     311     330 .]     310     330 .] 0.97

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.12
       PPR_2 15 kkgkveeAfklfneMkkrglePn 37
                k++++   ++++  Mkk g   n
  EFC39615.1 39 KRNEIMNTLEFYRRMKKEGSIIN 61
                5677788899*******996555 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 4.4
       PPR_2  17 gkveeAfklfneMkkr 32 
                 g++e A  l++  kkr
  EFC39615.1 115 GDIETARTLLKLLKKR 130
                 7888888888888876 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 4.6
       PPR_2   9 lIsglckkgkveeAfklfne 28 
                 l++   + g+v  A+ ++  
  EFC39615.1 157 LLQIIINTGDVTGAINFLRN 176
                 77788889999999988765 PP

  == domain 4  score: 25.1 bits;  conditional E-value: 8.5e-09
       PPR_2  19 veeAfklfneMkkrgl...ePnsyTysilikglc 49 
                 ++ A++lfn+M +      +P+++T+++li+g++
  EFC39615.1 218 MKRAMELFNWMDESDQvlvPPDEFTFTTLIRGYA 251
                 899**********854477*************86 PP

  == domain 5  score: 27.4 bits;  conditional E-value: 1.6e-09
       PPR_2   1 pdvvtyNtlIsglckkgkveeAfklfneMkkr.glePnsyTysilikgl 48 
                 pd +t++tlI g++  +++++A++lfn+M    g +P + T  i+i g+
  EFC39615.1 238 PDEFTFTTLIRGYALINDMSMAMELFNQMSTEyGMKPPTLTKDIIIEGF 286
                 899***************************955****999999999886 PP

  == domain 6  score: 14.5 bits;  conditional E-value: 1.7e-05
       PPR_2   8 tlIsglckkgkveeAfklfne 28 
                 ++I g+ k+g++e+Af++f++
  EFC39615.1 281 IIIEGFIKEGNIEKAFQFFKD 301
                 79*****************97 PP

  == domain 7  score: 12.7 bits;  conditional E-value: 6.1e-05
       PPR_2   6 yNtlIsglckkgkveeAfkl 25 
                 yN+lI+g+ ++g++ +Af+l
  EFC39615.1 311 YNSLITGFTHEGNLTKAFEL 330
                 9*****************97 PP

>> PPR_1  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.7   0.4      0.24   4.3e+02      23      33 ..     218     228 ..     217     229 .. 0.86
   2 !   29.6   0.0   2.2e-10     4e-07       4      34 .]     237     267 ..     236     267 .. 0.96
   3 !   12.6   0.0   4.7e-05     0.085      12      31 ..     281     300 ..     271     301 .. 0.90
   4 !   13.4   0.0   2.7e-05     0.048      10      29 ..     311     330 .]     310     330 .] 0.98

  Alignments for each domain:
  == domain 1  score: 0.7 bits;  conditional E-value: 0.24
                 HHHHHHHHHHH CS
       PPR_1  23 vdeAfelfdeM 33 
                 +++A+elf+ M
  EFC39615.1 218 MKRAMELFNWM 228
                 689*****977 PP

  == domain 2  score: 29.6 bits;  conditional E-value: 2.2e-10
                 ---HHHHHHHHHHHHHTS-HHHHHHHHHHHH CS
       PPR_1   4 kPdvvTYNtLIdGlCkaGrvdeAfelfdeMe 34 
                  Pd +T++tLI G+   +++  A+elf++M+
  EFC39615.1 237 PPDEFTFTTLIRGYALINDMSMAMELFNQMS 267
                 7*****************************5 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 4.7e-05
                 HHHHHHHHTS-HHHHHHHHH CS
       PPR_1  12 tLIdGlCkaGrvdeAfelfd 31 
                 ++I G+ k+G++++Af++f+
  EFC39615.1 281 IIIEGFIKEGNIEKAFQFFK 300
                 89****************97 PP

  == domain 4  score: 13.4 bits;  conditional E-value: 2.7e-05
                 HHHHHHHHHHTS-HHHHHHH CS
       PPR_1  10 YNtLIdGlCkaGrvdeAfel 29 
                 YN+LI G+  +G++ +Afel
  EFC39615.1 311 YNSLITGFTHEGNLTKAFEL 330
                 ******************98 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1      0.11   2.1e+02      20      30 ..      47      57 ..      36      58 .. 0.83
   2 ?   -0.4   0.0         1   1.8e+03      14      29 ..     115     130 ..     113     130 .. 0.88
   3 ?   -1.8   0.0       2.7   4.9e+03       2      12 ..     192     202 ..     191     205 .. 0.81
   4 ?   -1.8   0.1       2.8     5e+03      16      24 ..     218     226 ..     218     231 .. 0.80
   5 !   23.9   0.2   1.8e-08   3.2e-05       1      27 [.     241     267 ..     241     269 .. 0.95
   6 !   12.4   0.0   8.3e-05      0.15       5      25 ..     281     301 ..     280     307 .. 0.91
   7 !   14.6   0.0   1.7e-05      0.03       3      22 ..     311     330 .]     310     330 .] 0.97

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.11
         PPR 20 lelfkeMkekG 30
                le++++Mk++G
  EFC39615.1 47 LEFYRRMKKEG 57
                799******99 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 1
         PPR  14 GkleeAlelfkeMkek 29 
                 G++e A  l+k +k++
  EFC39615.1 115 GDIETARTLLKLLKKR 130
                 999********99985 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 2.7
         PPR   2 tynslIsgyck 12 
                 +++++++g+ k
  EFC39615.1 192 AFTVVLNGLIK 202
                 68999999987 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 2.8
         PPR  16 leeAlelfk 24 
                 ++ A+elf+
  EFC39615.1 218 MKRAMELFN 226
                 5789***97 PP

  == domain 5  score: 23.9 bits;  conditional E-value: 1.8e-08
         PPR   1 vtynslIsgycknGkleeAlelfkeMk 27 
                 +t+++lI+gy+  +++++A+elf++M 
  EFC39615.1 241 FTFTTLIRGYALINDMSMAMELFNQMS 267
                 69************************5 PP

  == domain 6  score: 12.4 bits;  conditional E-value: 8.3e-05
         PPR   5 slIsgycknGkleeAlelfke 25 
                 ++I g+ k+G++e+A+++fk+
  EFC39615.1 281 IIIEGFIKEGNIEKAFQFFKD 301
                 589****************96 PP

  == domain 7  score: 14.6 bits;  conditional E-value: 1.7e-05
         PPR   3 ynslIsgycknGkleeAlel 22 
                 ynslI g+ ++G+l +A+el
  EFC39615.1 311 YNSLITGFTHEGNLTKAFEL 330
                 9*****************97 PP

>> PPR_long  Pentacotripeptide-repeat region of PRORP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.12   2.2e+02      23      48 ..      39      64 ..      25     134 .. 0.54
   2 !   27.7   0.0   8.7e-10   1.6e-06      23     146 ..     163     297 ..     147     302 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.12
                HHT-HHHHHHHHHHHHHSSS---HHH CS
    PPR_long 23 kekDaaaAlelydkavaegvrlaqyh 48
                k++ +++ le y ++++eg  +++++
  EFC39615.1 39 KRNEIMNTLEFYRRMKKEGSIINSNK 64
                55666666666666666664444332 PP

  == domain 2  score: 27.7 bits;  conditional E-value: 8.7e-10
                 HHT-HHHHHHHHHHHHHSSS---HHH....HHHHHHHHHHC....HCSTTTHHHHHHHHHHHHHHHHH...TT----HHHHHHHHHHHHHTT-HHHHHH CS
    PPR_long  23 kekDaaaAlelydkavaegvrlaqyh....ynvllylcskae...aaseskknkalargfevfeamka...kgvspnEatvtalarlaaakedgdlafe 111
                  ++D+++A++   +a++e+ + a+y+    + v+l+ + k     +++ +++   ++r++e f+ m++     v+p E t+t+l+r  a  +d  +a e
  EFC39615.1 163 NTGDVTGAINFLRNAKNEHGQTAPYIgtsaFTVVLNGLIKEIkvfNPTCEHNLVVMKRAMELFNWMDEsdqVLVPPDEFTFTTLIRGYALINDMSMAME 261
                 689************9988666655333339999996666541224444455566999*****999986545689************************ PP

                 HHHHHH.HH-S---HHHHHHHHHHHHHTT-HHHHHH CS
    PPR_long 112 lvkeme.kagvsPrLRsyaPaLaayckagdadkale 146
                 l ++m+ ++g++P   + + ++  + k g+++ka++
  EFC39615.1 262 LFNQMStEYGMKPPTLTKDIIIEGFIKEGNIEKAFQ 297
                 *****7699***9999******************97 PP

>> RPN6_N  26S proteasome regulatory subunit RPN6 N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   1.1   4.4e-07   0.00079      12      93 ..      29     117 ..      18     140 .. 0.77

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 4.4e-07
      RPN6_N  12 aeelykeilskks..kede....ealreqeqalleLgelyrdqkkaeeLaelikesrsflssiaK.aKta.KlvrtLldlf.skipnslel 93 
                   e y+++l+k++     +     +  ++e ++++  +ly+d k+++ L e+ +e++ fl++  K +Kt  ++v tLld++ ++i++  ++
  EFC39615.1  29 TFENYEQVLKKRNeiM--NtlefYRRMKKEGSIINSNKLYQDGKQQSPLFEVYREVKFFLKANEKgSKTQlRVVETLLDKLvETIKEVGDI 117
                 5578999999999542..33556666789*********************************99967886589******862455555444 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.1       2.3   4.1e+03      36      45 ..      48      57 ..      35      58 .. 0.59
   2 ?   -2.0   0.1       2.2     4e+03      21      43 ..     107     129 ..     104     130 .. 0.81
   3 ?   -1.6   0.0       1.6   2.9e+03      19      42 ..     155     178 ..     153     181 .. 0.76
   4 !   14.5   0.0   1.6e-05     0.028      13      57 ..     238     283 ..     224     289 .. 0.84
   5 ?    4.5   0.0      0.02        37      18      36 ..     311     329 ..     307     330 .] 0.91

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 2.3
       PPR_3 36 evlermkkkg 45
                e   rmkk+g
  EFC39615.1 48 EFYRRMKKEG 57
                3345899987 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 2.2
       PPR_3  21 LLtayanagnkklalevlermkk 43 
                 L + ++ +g+ + a   l+ +kk
  EFC39615.1 107 LVETIKEVGDIETARTLLKLLKK 129
                 67778889999999999998887 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 1.6
       PPR_3  19 thLLtayanagnkklalevlermk 42 
                 t LL+ ++n+g+   a + l   k
  EFC39615.1 155 TKLLQIIINTGDVTGAINFLRNAK 178
                 789999999999887777666655 PP

  == domain 4  score: 14.5 bits;  conditional E-value: 1.6e-05
       PPR_3  13 ldvvtYthLLtayanagnkklalevlermk.kkgikPtvvtyNail 57 
                 +d  t+t+L+++ya+  +   a+e +++m  + g kP  +t  +i+
  EFC39615.1 238 PDEFTFTTLIRGYALINDMSMAMELFNQMStEYGMKPPTLTKDIII 283
                 6778*************************63669999888877776 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.02
       PPR_3  18 YthLLtayanagnkklale 36 
                 Y++L+t++   gn+  a+e
  EFC39615.1 311 YNSLITGFTHEGNLTKAFE 329
                 9*************99987 PP

>> ATP13  Mitochondrial ATPase expression
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       4.9   8.8e+03      82     108 ..      38      64 ..      30      70 .. 0.61
   2 ?   11.8   0.0   9.4e-05      0.17      48      87 ..     233     272 ..     213     281 .. 0.82
   3 ?   -0.6   0.0      0.63   1.1e+03      60      77 ..     282     299 ..     275     305 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 4.9
       ATP13  82 kkYpeielkkefWeellewaiiltskk 108
                 kk +ei +  ef++++ +   i++s+k
  EFC39615.1  38 KKRNEIMNTLEFYRRMKKEGSIINSNK 64 
                 444556666677777766666665555 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 9.4e-05
       ATP13  48 splyP.tselLkaivssfsynneiesAlklvdkfskkYpei 87 
                  +l+P +  + ++++ +++  n+++ A++l +++s++Y+ +
  EFC39615.1 233 QVLVPpDEFTFTTLIRGYALINDMSMAMELFNQMSTEYG-M 272
                 445442888999**************************9.4 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.63
       ATP13  60 ivssfsynneiesAlklv 77 
                 i+++f+++++ie+A+++ 
  EFC39615.1 282 IIEGFIKEGNIEKAFQFF 299
                 8999**********9875 PP

>> Hydantoinase_B  Hydantoinase B/oxoprolinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   4.2e-05     0.076     138     206 ..      52     120 ..      47     137 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4.2e-05
  Hydantoinase_B 138 eifeEGlrippvklveegeleedvlelllanvRtpednlgDlkAqiaanqvgerrlkelieeyGldtve 206
                      + +EG +i++ kl+++g+++  ++e+ ++   +++ n+   k+q+  +++  ++l e i+e+G  +  
      EFC39615.1  52 RMKKEGSIINSNKLYQDGKQQSPLFEVYREVKFFLKANEKGSKTQLRVVETLLDKLVETIKEVGDIETA 120
                     6789*************************9999*****************************9964444 PP

>> EF-G-binding_N  Elongation factor G-binding protein, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.4   0.00014      0.25       5      73 ..      95     175 ..      93     179 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00014
  EF-G-binding_N   5 yqYnfIkkqveqllnayrsvnDkkvveavkalaaekIlel.............fpelseeqkelLeqiddiktkekaeklLe 73 
                      q  +++  +++l+++ + v D ++ +++  l++++I +              + +l+++ ++lL+ i ++ + + a ++L+
      EFC39615.1  95 TQLRVVETLLDKLVETIKEVGDIETARTLLKLLKKRIDNCnemglssenivlqL-KLKPKITKLLQIIINTGDVTGAINFLR 175
                     688899999******************************988888888877633.477777888877777777777666665 PP

>> DUF4427  Protein of unknown function (DUF4427)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00012      0.22      59     104 ..      76     121 ..      62     132 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00012
     DUF4427  59 vkvskeGrylldlnlasvdrdlrrkealakelarllkqefdleaGr 104
                  +v +e +++l+ n+ +++ +lr  e+l  +l   +k+  d+e+ r
  EFC39615.1  76 FEVYREVKFFLKANEKGSKTQLRVVETLLDKLVETIKEVGDIETAR 121
                 6799**************************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (330 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1322  (0.0737353); expected 358.6 (0.02)
Passed bias filter:                      703  (0.0392102); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.67u 0.38s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 1801.87
//
Query:       EFC39616.1  [L=397]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.4e-14   52.2   0.1    1.2e-13   50.8   0.1    1.7  1  DNA_mis_repair  DNA mismatch repair protein, C-terminal domai
    1.3e-13   51.0   0.3    1.3e-13   51.0   0.3    2.2  3  HATPase_c_3     Histidine kinase-, DNA gyrase B-, and HSP90-l
    4.8e-06   27.1   0.4    1.1e-05   25.9   0.4    1.7  1  HATPase_c       Histidine kinase-, DNA gyrase B-, and HSP90-l
  ------ inclusion threshold ------
       0.57    9.7   8.0       0.25   10.9   5.3    1.8  2  PEARLI-4        Arabidopsis phospholipase-like protein (PEARL
        1.2    7.6  22.5        1.7    7.1  22.5    1.3  1  Macoilin        Macoilin family
        2.1    7.6  12.5        1.6    8.0  10.9    1.5  2  NOA36           NOA36 protein


Domain annotation for each model (and alignments):
>> DNA_mis_repair  DNA mismatch repair protein, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.8   0.1   3.9e-17   1.2e-13       3      81 ..     306     387 ..     304     394 .. 0.88

  Alignments for each domain:
  == domain 1  score: 50.8 bits;  conditional E-value: 3.9e-17
                     HHHHHHHHCCEEEEEEEETT...EEEEEEEE-CC..G-BTTGGEEEEEETTEEE--HHHHHHHHHHHHCCSSSSSB-EEEEEEE CS
  DNA_mis_repair   3 avlgkevaenlleiekeeeq...lkieGfiskpe..lsrskrdkqflfvNgRlvkskelkkaireaYkellpkgrypvvvLnle 81 
                     +++g +  ++l +++  +++   +ki+Gfis pe  + rs++d+qfl+vN+R+v+ ++++k+i+e+Yk ++++++yp+++ +++
      EFC39616.1 306 SIFGLKDFKKLQKVDFIQNDphfIKINGFISLPEkgCGRSSNDRQFLYVNNRPVDLPKITKCINEIYK-EFNRNQYPIFI-YMK 387
                     689999999**9**977777789**********878********************************.89999999864.444 PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       2.4   7.1e+03      95     109 ..      17      31 ..      11      56 .. 0.52
   2 ?   -1.9   0.3      0.92   2.8e+03     114     114 ..      78      78 ..      42     130 .. 0.59
   3 !   51.0   0.3   4.2e-17   1.3e-13       2     106 ..     185     289 ..     184     317 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 2.4
  HATPase_c_3  95 egesstltldvdkid 109
                  + ++stlt+++++  
   EFC39616.1  17 KKTTSTLTIKRKANT 31 
                  333444555554333 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 0.92
  HATPase_c_3 114 k 114
                  +
   EFC39616.1  78 N 78 
                  2 PP

  == domain 3  score: 51.0 bits;  conditional E-value: 4.2e-17
  HATPase_c_3   2 slekAlaelvdNsldAdaenvkievnknrgktgeivieDdGkGmseeelknalrlatsskeak.rkstslGkkGi.GlklAslslgkkltvitkkege 97 
                  sl++++ el++NsldA+++ ++i++ +     + i + D+G+G+s+++++n  + +++sk  + ++ + ++ +G+ G  l+s+s  ++l+++tk+e++
   EFC39616.1 185 SLTSVIKELIENSLDASSTFIEIKFTNMG--LECIEVSDNGNGISKNNFENIVKKHNTSKLINfTDLENISTFGFrGEALSSISCMAELQIFTKTESD 280
                  67899*********************964..6899******************99999999774577889****99********************99 PP

  HATPase_c_3  98 sstltldvd 106
                  +  + + +d
   EFC39616.1 281 KLGNLIYYD 289
                  886666655 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.9   0.4   3.8e-09   1.1e-05       4      73 ..     184     256 ..     181     297 .. 0.74

  Alignments for each domain:
  == domain 1  score: 25.9 bits;  conditional E-value: 3.8e-09
                 HHHHHHHHHHHHHHHHHHSTTTEEEEEEEEEE.TEEEEEEEESSSSSTTHHHTGTCSTTCH......HCSTCHTSTS CS
   HATPase_c   4 krLrqiisnlvdNavkfatkageieveikase.ddlvisveDnGiGipkedlkklfekfsq......ddstkrgggg 73 
                 + L+ +i++l++N++++  +++ ie++ +  + +  +i+v+DnG Gi+k++ +++ +k+ +       d ++++++g
  EFC39616.1 184 ISLTSVIKELIENSLDA--SSTFIEIKFT--NmGLECIEVSDNGNGISKNNFENIVKKHNTsklinfTDLENISTFG 256
                 67999***********7..5566666666..4468899***************999987776677664444444433 PP

>> PEARLI-4  Arabidopsis phospholipase-like protein (PEARLI 4)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   5.3   8.2e-05      0.25       2      84 ..      80     180 ..      79     204 .. 0.69
   2 ?   -3.3   0.0       1.8   5.3e+03      54      80 ..     270     296 ..     263     307 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 8.2e-05
    PEARLI-4   2 dkdsvlLfpelllspqerkesesitlvhrkyetp............sedeeeekkneepveLpdes......qsftlaeiskmkglktyeikeelqsvl 82 
                 ++ s +Lf++l++sp++  + +++ l++ + +++             ++++e++++e+p+e  de       + +t +ei + k+++ +  ++ ++ + 
  EFC39616.1  80 NNRSFSLFNQLISSPSSSSSTNNNKLNQSNNNITviplpednnnddENNNDENNNDEDPIENNDENnkdeeeEEITNEEIFQSKSIISKLSNNSIHRIC 178
                 67799*************999999999999998889******998844555555556666665554111111445666777777776665555555555 PP

    PEARLI-4  83 se 84 
                 s 
  EFC39616.1 179 SG 180
                 54 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.8
    PEARLI-4  54 esqsftlaeiskmkglktyeikeelqs 80 
                 e q ft +e +k+  l+ y+  ++++ 
  EFC39616.1 270 ELQIFTKTESDKLGNLIYYDHDQNITK 296
                 678899999999999988876666554 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1  22.5   0.00058       1.7     263     401 ..       9     169 ..       2     249 .. 0.74

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.00058
    Macoilin 263 kssrsdskkkhehnesvdsklqekeymenkskskrlsksessgsesellvee..svkskssssssssnknskkasagsagssnssskkhsessksvtss 359
                 +++ ++++kk + + ++++k++  + +++++++ ++  s+ss+s  +++ ++  s++s +sssssssn+n+++ s +  ++  ss+ + s++++++ + 
  EFC39616.1   9 NNNINNTTKKTTSTLTIKRKANTSNLIASELSPSPSPISSSSSSCITTTPQSssSTSSIASSSSSSSNNNNNNRSFSLFNQLISSPSSSSSTNNNKLNQ 107
                 344556666667678899999999999999999999988888887776655400455556667777777777777777888888877766655544433 PP

    Macoilin 360 s...................ssknskkqklpaGkssaalkdaaenslpnnqlskkdalv.rL 401
                 s                   ++++++ ++ p  ++ +++kd+ e+ ++n+++ + + ++ +L
  EFC39616.1 108 SnnnitviplpednnnddenNNDENNNDEDPIENNDENNKDEEEEEITNEEIFQSKSIIsKL 169
                 33789999999987777653333334446788888889999999999999986555544344 PP

>> NOA36  NOA36 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0  10.9   0.00052       1.6     266     303 ..     104     154 ..      49     160 .. 0.46
   2 ?   -3.2   0.0       1.4   4.2e+03      44      70 ..     341     367 ..     335     369 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00052
       NOA36 266 g................ddeddegdedddddddeedddeeeddedeeeeeeees 303
                 +                +++dde+++d++++d   +d  e++de++++eeeee 
  EFC39616.1 104 KlnqsnnnitviplpedNNNDDENNNDENNND---EDPIENNDENNKDEEEEEI 154
                 02222222233333211233333333333332...2323333333333333333 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.4
       NOA36  44 kcerkqknrafcyfcqsvqrlpicakc 70 
                  c r  ++r f y  +    lp  +kc
  EFC39616.1 341 GCGRSSNDRQFLYVNNRPVDLPKITKC 367
                 588999999999998888888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2278  (0.127057); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.78u 0.39s 00:00:01.17 Elapsed: 00:00:00.55
# Mc/sec: 2179.73
//
Query:       EFC39617.1  [L=587]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (587 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       639  (0.0356406); expected 358.6 (0.02)
Passed bias filter:                      293  (0.0163422); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.28s 00:00:00.94 Elapsed: 00:00:00.49
# Mc/sec: 3576.42
//
Query:       EFC39618.1  [L=461]
Description: rho GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    3.3e-29  101.6   0.0    1.3e-28   99.6   0.0    2.1  2  Ras         Ras family
    5.4e-09   36.3   0.4    5.8e-07   29.8   0.0    3.2  2  Roc         Ras of Complex, Roc, domain of DAPkinase
     0.0019   18.1   0.4     0.0019   18.1   0.4    2.3  3  F-box       F-box domain
  ------ inclusion threshold ------
      0.022   14.7   0.5       0.06   13.3   0.5    1.7  1  MIT_C       Phospholipase D-like domain at C-terminus of MIT
      0.029   13.8   0.0        0.1   12.1   0.0    1.9  2  Arf         ADP-ribosylation factor family
      0.043   13.7   0.5       0.11   12.5   0.1    1.9  2  F-box-like  F-box-like
       0.19   11.5   1.2        0.3   10.8   0.2    1.8  2  DUF4597     Domain of unknown function (DUF4597)


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1       0.8     2e+03      92      92 ..     208     208 ..     173     261 .. 0.50
   2 !   99.6   0.0   5.3e-32   1.3e-28       1     160 [.     278     440 ..     278     442 .. 0.95

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.8
                 H CS
         Ras  92 k 92 
                 +
  EFC39618.1 208 R 208
                 2 PP

  == domain 2  score: 99.6 bits;  conditional E-value: 5.3e-32
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 K+v vGd+avGKt+ll r+ +++++++y++T+ +d+++ +++v++k++++         ++++lr+l+y +++ +l+ ++  s++sf nv  kw+ ei+
  EFC39618.1 278 KVVAVGDGAVGKTTLLKRYSSGDYPNDYIPTV-FDNHNISVKVEDKTYSI---------DYDRLRPLSYPGTSLFLVNFSCVSEASFFNVVtKWLPEIR 366
                 89******************************.99999999999999988.........5**************************988776******* PP

                 HHSTTTSEEEEEEETTTGGG.............G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  99 rvaeenvpivLvGnKvDlee.............kravsteegeelakelg.lkfletSAktnenveeafeellrei 160
                 ++++   p++Lv +K+D ++             ++ +++e+ge +ak++g ++++etS kt ++++++   +lr+i
  EFC39618.1 367 HHCT--APVALVNTKIDYRTdsilnkefilkyeEKPITFEQGELMAKNMGcATYIETSSKTGYGLDDLSSVILRTI 440
                 ***9..6*******************************************999************99988888876 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.4      0.32   8.2e+02      13      52 ..     200     238 ..     196     245 .. 0.76
   2 !   29.8   0.0   2.3e-10   5.8e-07       1     119 [.     278     381 ..     278     382 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.32
                 HHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTT CS
         Roc  13 tsllkrfvedkfsekekstigvdfltkevtkikgvendkk 52 
                 + ++++++++k + ke+ t +v+ + ++v+  k++e + k
  EFC39618.1 200 SRIFDSYLRKKSNYKENLTQAVQAIMSKVE-KKNIERTLK 238
                 56889999999999999**99999998874.455555444 PP

  == domain 2  score: 29.8 bits;  conditional E-value: 2.3e-10
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHH.HCH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srss.enl 95 
                 Kvv vGd++vGKt+llkr+ ++++ +++ +t+  +    ++               ++++ D     +++ l+pl + + +l+++ +    + s+ + +
  EFC39618.1 278 KVVAVGDGAVGKTTLLKRYSSGDYPNDYIPTVFDNH---NI---------------SVKVEDKTYSIDYDRLRPLSYPGTSLFLVNFScvsEASFfNVV 358
                 9*****************************984433...33...............33344555566899**************988766444552556 PP

                 HHHHHHHHHHCSSS-EEEEEE-TT CS
         Roc  96 keWlkelkkvagkspvilvgnkiD 119
                  +Wl e++++++ +pv lv +kiD
  EFC39618.1 359 TKWLPEIRHHCT-APVALVNTKID 381
                 99******9995.79999999999 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.4   7.3e-07    0.0019       6      37 ..     125     156 ..     123     158 .. 0.93
   2 ?   -2.0   0.0       1.5   3.7e+03      23      30 ..     343     350 ..     333     351 .. 0.80
   3 ?   -2.8   0.1       2.5   6.3e+03       3      14 ..     429     440 ..     429     440 .. 0.85

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 7.3e-07
                 S-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHH CS
       F-box   6 LPsevlrhILerLplsdllalrrVSkgwrili 37 
                 + +++ r +L++L+  dl  l +VSk++ri++
  EFC39618.1 125 VNDDIFRTVLSFLSIQDLMKLHLVSKSLRICT 156
                 6799**************************96 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 1.5
                 HHHHCTT- CS
       F-box  23 llalrrVS 30 
                 l+++++VS
  EFC39618.1 343 LVNFSCVS 350
                 899****9 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 2.5
                 HHHS-HHHHHHH CS
       F-box   3 lsrLPsevlrhI 14 
                 l++L+s +lr I
  EFC39618.1 429 LDDLSSVILRTI 440
                 5799**999987 PP

>> MIT_C  Phospholipase D-like domain at C-terminus of MIT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.5   2.3e-05      0.06       3      55 ..     185     237 ..     184     262 .. 0.76

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.3e-05
       MIT_C   3 sYeslfgkylddateikiedpYirarhqi.rnlvrllellvkkskklkkikLlT 55 
                 sY+ ++ ky+ d+t+  i d+Y+r++  + +nl++ ++++++k  ++k+i+ + 
  EFC39618.1 185 SYDYVLCKYVFDTTQSRIFDSYLRKKSNYkENLTQAVQAIMSK-VEKKNIERTL 237
                 8***********************99887369******99999.3334443333 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.84   2.2e+03     129     158 ..     226     254 ..     218     270 .. 0.67
   2 ?   12.1   0.0   3.9e-05       0.1      15      52 ..     277     314 ..     261     328 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.84
                 TSS-HHHHHHHTTGGGSSSSSSEEEEEEBT CS
         Arf 129 ealseeelrellgleelkgkrkleiqkcsa 158
                 + +++++++++l++ee+k +rk   q cs 
  EFC39618.1 226 SKVEKKNIERTLKIEEVK-QRKDGRQYCSK 254
                 567788888889999988.66655555555 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 3.9e-05
                 EEEEEEESTTSSHHHHHHHHHHSSCEE.CSSSSSEEEEE CS
         Arf  15 lrilllGLDnaGKtTilkklkleelvt.tvPTigfnvee 52 
                 ++++ +G  + GKtT+lk++++++  +  +PT+  n  +
  EFC39618.1 277 FKVVAVGDGAVGKTTLLKRYSSGDYPNdYIPTVFDNH-N 314
                 79999**9999***********999775899985543.3 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   4.1e-05      0.11       7      47 ..     128     169 ..     127     170 .. 0.82
   2 ?   -2.8   0.0       2.4     6e+03      16      27 ..     252     263 ..     250     263 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 4.1e-05
  F-box-like   7 EiLlqIFsyLppsdLlrlalVCrrWrrvaldt.plLWrrlvl 47 
                 +i  +++s+L+ +dL  l lV+++ r ++l+t  + W   ++
  EFC39618.1 128 DIFRTVLSFLSIQDLMKLHLVSKSLRICTLTTeDQYWEDFYF 169
                 6777899*****************999997775677776665 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 2.4
  F-box-like  16 LppsdLlrlalV 27 
                  + s+Ll+ ++V
  EFC39618.1 252 CSKSELLNYSHV 263
                 56789****998 PP

>> DUF4597  Domain of unknown function (DUF4597)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       3.3   8.5e+03       7      15 ..      50      59 ..      47      61 .. 0.67
   2 ?   10.8   0.2   0.00012       0.3      23      54 ..      85     117 ..      81     120 .. 0.87

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 3.3
     DUF4597  7 ssneea.PvL 15
                s++eea PvL
  EFC39618.1 50 SNKEEAqPVL 59
                5666765888 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00012
     DUF4597  23 Pdii.itPPtPtgmtlpRDsrravwlDetgsys 54 
                 Pd++ + PPt t++t ++   +++   et+s++
  EFC39618.1  85 PDVLtVSPPTTTSITSSKKDGKSITKSETSSFN 117
                 6764389**********************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (461 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1144  (0.0638072); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.70u 0.31s 00:00:01.01 Elapsed: 00:00:00.52
# Mc/sec: 2677.13
//
Query:       EFC39619.1  [L=120]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      0.002   18.7   0.6     0.0027   18.3   0.6    1.2  1  NDUFB11          NADH-ubiquinone oxidoreductase 11 kDa subuni
  ------ inclusion threshold ------
       0.05   13.5   0.2      0.075   13.0   0.2    1.2  1  End_beta_barrel  Beta barrel domain of bacteriophage endosial
       0.11   10.9   0.6        0.2   10.2   0.2    1.6  2  PAF-AH_p_II      Platelet-activating factor acetylhydrolase, 


Domain annotation for each model (and alignments):
>> NDUFB11  NADH-ubiquinone oxidoreductase 11 kDa subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.3   0.6   4.5e-07    0.0027      11      67 ..      41      98 ..      33     113 .. 0.80

  Alignments for each domain:
  == domain 1  score: 18.3 bits;  conditional E-value: 4.5e-07
     NDUFB11 11 lilrlmedPkerdrkarehvyevkekckklkelwsl.PlrPyGfwtferhnaqlakda 67
                li   m   k+  +  r +vye +e+ k+ k  w+l     yG wt  r  +++ +d 
  EFC39619.1 41 LIDNNMMRTKDLIESRRIRVYEEEERMKQRKLEWQLlSYSSYGNWTRTRSQVKFLQDK 98
                555555555666667799*************9998637899**************996 PP

>> End_beta_barrel  Beta barrel domain of bacteriophage endosialidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.2   1.2e-05     0.075      41      67 ..      20      46 ..      12      53 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
                     STT--EEEEEEEEEETTEEEEE-S--- CS
  End_beta_barrel 41 vtGvsGnmtvatvidkntftvttsntq 67
                     + Gv G +tva+++++n+   +++n+ 
       EFC39619.1 20 ILGVVGGITVASILNQNAISTLIDNNM 46
                     67****************999888865 PP

>> PAF-AH_p_II  Platelet-activating factor acetylhydrolase, isoform II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0     0.068     4e+02     142     143 ..      39      40 ..       2      77 .. 0.41
   2 ?   10.2   0.2   3.3e-05       0.2     346     378 ..      86     117 ..      64     118 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.068
                  EE CS
  PAF-AH_p_II 142 at 143
                   t
   EFC39619.1  39 ST 40 
                  22 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 3.3e-05
                  HHHHHHHHHHHHHHT--SSGGGGHHHHTT-STT CS
  PAF-AH_p_II 346 iankaslaFLqkhldlkkdfdqwdnlveglden 378
                    +++ ++FLq++l+ +k+ + wd  ++glde+
   EFC39619.1  86 TRTRSQVKFLQDKLE-HKERNVWDDMIQGLDEK 117
                  5689**********9.*************9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (120 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       986  (0.0549947); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.54u 0.33s 00:00:00.87 Elapsed: 00:00:00.52
# Mc/sec: 691.53
//
Query:       EFC39620.1  [L=521]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.2    8.8   6.0        1.2    9.7   1.0    3.1  3  PCI       PCI domain


Domain annotation for each model (and alignments):
>> PCI  PCI domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   1.0   6.6e-05       1.2       8      72 ..      68     153 ..      61     165 .. 0.88
   2 ?   -2.3   0.1      0.35   6.2e+03      57      87 ..     389     420 ..     362     422 .. 0.66
   3 ?   -1.3   0.0      0.17     3e+03       2      35 ..     461     494 ..     461     500 .. 0.82

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 6.6e-05
                 HHHHHTSHHHHHHHHHHH......................HHHHHHHTTHHHHHHHHHHHHHHHHHHHHHHCESEEEHHHHHHHHTS CS
         PCI   8 kalrsgnlsgfseelkdl......................eeelladdglaqllesLekkvrerllrqvskiyssislerlaklldl 72 
                 k ++++ +s +s +++++                      ++++ + ++++q++++ e +++++++ ++++  + +++++l kl++l
  EFC39620.1  68 KLMKNQVISFYSAAVQKFisigdsfyyydlviyqfmqvllCKNIERSPYMRQYVPE-ETNLIRECIGKIIRMNQYLDYSKLGKLFEL 153
                 566677788899999999999999999999999999999****************9.77888999********************98 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.35
                 CESEEEHHHHHHHHTSSH.HHHHHHHHHHHHT CS
         PCI  57 iyssislerlaklldlsv.devEkilvklIrd 87 
                  +s ++++r+++  + +  ++v +++++ +++
  EFC39620.1 389 NQSVFEMSRISEHDQTFIiNNVKELIIQIVNN 420
                 45556666666666666677777777777765 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.17
                 HHHHHHHHHHHTSHHHHHHHHHHHHHHHHHHTTH CS
         PCI   2 sysdllkalrsgnlsgfseelkdleeelladdgl 35 
                 s+++ l+ l++  + ++ e +kd+ ++ll + ++
  EFC39620.1 461 SFREYLNVLYKHAWYDVHERMKDHVKTLLGKNNI 494
                 58899999999999999******98877776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (521 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1204  (0.0671538); expected 358.6 (0.02)
Passed bias filter:                      551  (0.0307323); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 2913.71
//
Query:       EFC39621.1  [L=463]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.3e-07   29.7  10.5    1.8e-06   28.0  10.5    2.0  1  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain
  ------ inclusion threshold ------
       0.03   14.5   0.2      0.064   13.4   0.2    1.5  1  CD225     Interferon-induced transmembrane protein
       0.14   12.5   0.0       0.29   11.4   0.0    1.5  1  TPR_12    Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0  10.5     3e-10   1.8e-06       2      38 ..      58      93 ..      57      96 .. 0.88

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 3e-10
                S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCC CS
     Zn_clus  2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysessk 38
                +Cd Cr  +++Cd+ kP+C  C  ++ +C+ ys   k
  EFC39621.1 58 SCDGCRVNHRRCDRTKPSCHGCSLRGMTCK-YSTNYK 93
                8*****************************.655444 PP

>> CD225  Interferon-induced transmembrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.2   1.1e-05     0.064      23      51 ..     151     179 ..     150     183 .. 0.94

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.1e-05
       CD225  23 vAlvySvkvrdrkmvGdvegAqsasstAk 51 
                 +Al+yS+k++   ++G++e++++++++Ak
  EFC39621.1 151 AALYYSIKASCECQMGNIEKSEKSAKQAK 179
                 79**************************9 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   4.9e-05      0.29       2      50 ..     150     200 ..     149     201 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4.9e-05
      TPR_12   2 vatalnn.laavlrrlgrydeAlellekaleiarrllGpdh.pltattlrn 50 
                 +a++++   a++++++g+ +++++  ++a +  +++++ ++   +a+t+ n
  EFC39621.1 150 MAALYYSiKASCECQMGNIEKSEKSAKQAKDYLSKVFDSHSsTRVAITYLN 200
                 677788779************************999777665777777776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (463 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1107  (0.0617435); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 2764.12
//
Query:       EFC39622.1  [L=265]
Description: TCCD-inducible-PARP-like domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.1e-27   96.9   2.3    7.7e-27   94.1   2.3    2.2  1  PARP      Poly(ADP-ribose) polymerase catalytic domain


Domain annotation for each model (and alignments):
>> PARP  Poly(ADP-ribose) polymerase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.1   2.3   4.3e-31   7.7e-27      21     194 ..     101     263 ..      64     264 .. 0.73

  Alignments for each domain:
  == domain 1  score: 94.1 bits;  conditional E-value: 4.3e-31
                 EEEEEEEEE..EEEETTHHHHCGCCGG.....SS-EEEEEEEE-GGGHHHHHHH-S--S-TTS-GGGSTTSSSEEEBSSHHHHHGGG--BSSS-EEEEE CS
        PARP  21 yklkileif..rvqregeaerfqekkk.....lrnrrlLfHGsrltnvasilsqGLriappeapvtGymfGkGiYfAddaskSanYcktsekkgsglll 112
                 y++ +  i+    q  + +++f++ k       +n+++L+HG++ +++ si ++G+  + ++a++ G  fG G+YfA+  skS +Yc++ + +++  l+
  EFC39622.1 101 YQDPLNSIQvqTEQLAKTSKSFEWMKTvglngGMNEKYLWHGTKPEFISSISEHGF--DERVASL-GGLFGAGVYFAEYCSKSDQYCTP-DRNNEYSLF 195
                 4444433330033333455667777769999999**********************..*******.999*******************9.7788888** PP

                 EEEEE--SEEEESS--T.GCCGGTT-SEEEE-EEEEEGG.EEETTE--S-E..EE-S--SSSEEE-EEEESSGGGEEEEEEEEEE CS
        PARP 113 LaeValGdikeltkady.lekakkgkksvkgkgktepesivekdgvPlgks..satkyesseleyneyvvydkeqvrlkYLlevk 194
                 L++V+lG   +++     ++++              +    e +g+ ++    +  +++ s++ y+e +vyd  q++++Y++++k
  EFC39622.1 196 LCRVLLGR--QIYYTPKrMTNE--------------R-RPPEINGTNRRVFdsVIGNSNASNSAYRELIVYDRYQCYPEYIIKYK 263
                 ********..222222213222..............2.22334443333222145566667799*******************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (265 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       707  (0.0394333); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.29s 00:00:00.85 Elapsed: 00:00:00.49
# Mc/sec: 1628.74
//
Query:       EFC39623.1  [L=192]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.05   13.7   0.3      0.098   12.7   0.3    1.4  1  NPP       Pro-opiomelanocortin, N-terminal region


Domain annotation for each model (and alignments):
>> NPP  Pro-opiomelanocortin, N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.3   5.5e-06     0.098      12      28 ..      75      91 ..      72      97 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.5e-06
         NPP 12 ssEaslleCikaCrsdl 28
                +s+++++e+ik C+ + 
  EFC39623.1 75 DSDTNMMEFIKYCKLES 91
                79************764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (192 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2249  (0.125439); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1223.91
//
Query:       EFC39624.1  [L=617]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    7.4e-55  185.1   0.1    1.5e-54  184.1   0.1    1.5  1  Arf        ADP-ribosylation factor family
    5.9e-11   42.6   0.0    1.2e-10   41.6   0.0    1.5  1  Roc        Ras of Complex, Roc, domain of DAPkinase
    5.2e-10   39.1   0.0    9.5e-10   38.3   0.0    1.5  1  Ras        Ras family
    5.4e-10   39.0   0.0    9.1e-10   38.3   0.0    1.3  1  SRPRB      Signal recognition particle receptor beta subunit
    8.8e-10   38.3   9.3    4.4e-06   26.1   0.1    2.8  3  G-alpha    G-protein alpha subunit
      4e-07   29.6   0.7    1.5e-06   27.7   0.0    2.1  2  Gtr1_RagA  Gtr1/RagA G protein conserved region
    8.8e-07   29.1   0.3    1.6e-06   28.3   0.3    1.5  1  BTB        BTB/POZ domain
    2.5e-06   27.5   0.0    5.7e-06   26.4   0.0    1.6  1  MMR_HSR1   50S ribosome-binding GTPase
  ------ inclusion threshold ------
      0.057   13.5   0.1        1.4    9.0   0.0    2.4  2  Dynamin_N  Dynamin family


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  184.1   0.1   7.4e-58   1.5e-54       3     174 ..     419     591 ..     417     592 .. 0.96

  Alignments for each domain:
  == domain 1  score: 184.1 bits;  conditional E-value: 7.4e-58
                 HHHHGGTT.TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGG...GGGGGGCTTESEEEEEEETT-CTTHH CS
         Arf   3 silaklklkkkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklR...plWknYfektdavifvvDsadreRle 98 
                 +i +k++  + +lr lllGLD++GKtTil+++k++e   t+PTigfnve+le  + ++ +wD+GG+ek R   ++Wk+Y+++td ++fv+Ds+dr+Rl+
  EFC39624.1 419 KIPEKVNYINTKLRFLLLGLDSSGKTTILNQFKSGEPGVTTPTIGFNVETLERGTAEICIWDIGGNEKNRspqKVWKHYLSNTDCILFVLDSNDRQRLQ 517
                 56677888899********************************************************99955569************************ PP

                 HHHHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf  99 eakeeLkalleeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlses 174
                 ea ++L+++l+++elk++++lv+aNKqD+++++s+ el +ll+l++ +  +k+++q+c+a++g gl++glew +++
  EFC39624.1 518 EATDDLNRILKDDELKNCPILVFANKQDISTSMSRVELVSLLKLHTFR--QKWYVQSCCAITGLGLSDGLEWAIQT 591
                 ***********************************************9..9*********************9876 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.6   0.0   6.1e-14   1.2e-10       2     119 ..     433     545 ..     432     546 .. 0.78

  Alignments for each domain:
  == domain 1  score: 41.6 bits;  conditional E-value: 6.1e-14
                 EEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTT...T-HHHHCTSCEEEEEEEGHHHHCHHH CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrs...lhplylreaalailvydsrssenlke 97 
                  +l+G  ++GKt++l++f +++    +++tig ++ t e    +g        + ++ iWD++G+e+ rs   + ++yl++ +++++v+ds++ ++l+e
  EFC39624.1 433 FLLLGLDSSGKTTILNQFKSGEP-GVTTPTIGFNVETLE----RG--------TAEICIWDIGGNEKNRSpqkVWKHYLSNTDCILFVLDSNDRQRLQE 518
                 689****************9887.56689****996643....12........45799*********9974447799*************998888877 PP

                 HHHHHHHH.....CSSS-EEEEEE-TT CS
         Roc  98 Wlkelkkv.....agkspvilvgnkiD 119
                   ++l++       +++p+++ +nk D
  EFC39624.1 519 ATDDLNRIlkddeLKNCPILVFANKQD 545
                 6666655421122457899999***98 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3   0.0   4.8e-13   9.5e-10       2     132 ..     433     563 ..     432     594 .. 0.76

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 4.8e-13
                 EEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHH...HHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHH CS
         Ras   2 lvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefks...lrelyyrdaegillvyditsresfenvkkwveei 97 
                 ++l+G  + GKt++l++f +++ +   ++Tig++  t    ++  ++++ iwD  G e+ +s   + + y++++++il v d ++r+ ++++++ ++ i
  EFC39624.1 433 FLLLGLDSSGKTTILNQFKSGE-PGVTTPTIGFNVET----LERGTAEICIWDIGGNEKNRSpqkVWKHYLSNTDCILFVLDSNDRQRLQEATDDLNRI 526
                 689***************9999.78889***877654....566788899********98752227789************************888888 PP

                 HHHST.TTSEEEEEEETTTGGG.G-SS-HHHHHHHHH CS
         Ras  98 krvae.envpivLvGnKvDlee.kravsteegeelak 132
                  +  e +n+pi++ +nK D+++    v+  +  +l+ 
  EFC39624.1 527 LKDDElKNCPILVFANKQDISTsMSRVELVSLLKLHT 563
                 7777779*************98433444444444444 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.3   0.0   4.6e-13   9.1e-10       3     129 ..     430     551 ..     428     559 .. 0.85

  Alignments for each domain:
  == domain 1  score: 38.3 bits;  conditional E-value: 4.6e-13
                 --EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHHH CS
       SRPRB   3 kpavllvGlsdsGKTslftrLttdsvkktvtSq.essaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAElly 100
                 k ++ll+Gl  sGKT+++++  +++   t   +  +  +l+       ++ + D+ G+ek r+  +    + s+   ++fv+DS  d ++++e  + l 
  EFC39624.1 430 KLRFLLLGLDSSGKTTILNQFKSGEPGVTTPTIgFNVETLER---GTAEICIWDIGGNEKNRSPQKVWKHYLSNTDCILFVLDSN-DRQRLQEATDDLN 524
                 5689********************999888888555555554...7789999**********866666669999*********97.77789999***** PP

                 HHHHHHHHHTT---EEEEEE-TTSTT--- CS
       SRPRB 101 eilliteklkdavdiliACnKqelflaks 129
                  il + e   ++ +il+  nKq+++++ s
  EFC39624.1 525 RILKDDE--LKNCPILVFANKQDISTSMS 551
                 *****99..346899*********99865 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.8       1.3   2.6e+03     254     299 ..      62     108 ..      42     154 .. 0.61
   2 !   17.9   0.2   6.8e-07    0.0014      21      44 ..     428     451 ..     413     463 .. 0.81
   3 !   26.1   0.1   2.2e-09   4.4e-06     187     281 ..     460     546 ..     456     549 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.3
                 HHHHHHCCCC-GGG.TTSEEEEEEE-HHHHHHHCCCS-GGGCCTT-- CS
     G-alpha 254 slklFkeicnnkll.kntpiiLflnKlDileeKlkkgklskyfpsye 299
                 s k+++++++ +    +++  ++  K+ +le K ++  ++ ++p++ 
  EFC39624.1  62 SPKIYHDLFKVEQChDDSENSFLIKKFNLLETKKETIYFTIHIPEIR 108
                 55555555554444344444445555555555555555555555554 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 6.8e-07
                 ..EEEEEEEESTTSSHHHHHHHHH CS
     G-alpha  21 krevkllllGqseSGKsTilkqlk 44 
                 ++++++lllG ++SGK+Til+q+k
  EFC39624.1 428 NTKLRFLLLGLDSSGKTTILNQFK 451
                 3479*******************9 PP

  == domain 3  score: 26.1 bits;  conditional E-value: 2.2e-09
                 ---SEEEEEEECT-TEEEEEEEE-SS...HHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHH CS
     G-alpha 187 ktvGisetkfevdsklefrivdvgGq...rserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDi 281
                 +t+G++  ++e + + e+ i+d+gG    rs +k W+++++++d+i+F+            ++  +rl+e+ +  + i++  +lkn+pi++f nK Di
  EFC39624.1 460 PTIGFNVETLERG-TAEICIWDIGGNeknRSPQKVWKHYLSNTDCILFVLD----------SNDRQRLQEATDDLNRILKDDELKNCPILVFANKQDI 546
                 5666666666667.8999*******8222456799**************65..........55679*******************************8 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.4      0.43   8.7e+02      91     143 ..      58     110 ..      24     129 .. 0.72
   2 !   27.7   0.0   7.8e-10   1.5e-06       2     133 ..     433     556 ..     432     571 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.43
   Gtr1_RagA  91 leedletlkeilealrqyspeakvfvlihKmDliqedereeifeerkeeiree 143
                  +++  ++ + l ++ q++ + +   li K+ l++ ++++  f+ +  eir++
  EFC39624.1  58 ANNNSPKIYHDLFKVEQCHDDSENSFLIKKFNLLETKKETIYFTIHIPEIRKK 110
                 444445555566678999999999999****9998888888887777777665 PP

  == domain 2  score: 27.7 bits;  conditional E-value: 7.8e-10
   Gtr1_RagA   2 vLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletlk 99 
                  LL+G  +sGKt++ +    ++   +    + ti  + +++   g  ++ +wD+gG e+    +  +  ++ ++n + +++V+D+++r+ l+e+ ++l+
  EFC39624.1 433 FLLLGLDSSGKTTILN----QFKSGEPGVTTPTIGFNVETL-ERGTAEICIWDIGGNEKNRSPQ--KVWKHYLSNTDCILFVLDSNDRQrLQEATDDLN 524
                 69**********9765....556666666678999999999.5899************998886..888999***************9779******** PP

   Gtr1_RagA 100 eilealrqyspeakvfvlihKmDliqedereeif 133
                 +il+   +  ++  + v+ +K D  +++ r e++
  EFC39624.1 525 RILKD--DELKNCPILVFANKQDISTSMSRVELV 556
                 **996..6678899999******99999988776 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.3   8.1e-10   1.6e-06      19     108 ..     106     210 ..      88     213 .. 0.86

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 8.1e-10
                 T.TEEEEE-HHHHHHH-HHHHHHHTSTTTTTCCCEEEEETTSGHH...HHHHHHHHHHHSEEEC-............CGGGHHHHHHHHHHHT-HHHHH CS
         BTB  19 d.gkefkahkavLaarSpyFkalftskeieessvseielddvepe...afealLefiYtgeleit............seenleelLaaadllqiprlkk 101
                 + +k++ + +   +  S++F+a+++ + ++es+++e++l+++e +    fe+++efi+ g+l ++             +++l elL++ad +qi++l++
  EFC39624.1 106 EiRKKLLVSRELIMLESKVFEAMLNIE-MAESKSNEMTLQNCEKSwcdYFEMVIEFIHVGKLGLSkrlfnendariiGWKDLLELLKIADEYQIESLIR 203
                 4467777888888999***********.99*999********9855559****************************9********************* PP

                 HHHHHHH CS
         BTB 102 aceeflk 108
                 a+++ + 
  EFC39624.1 204 AISRVVN 210
                 9988766 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.4   0.0   2.9e-09   5.7e-06       2     114 .]     433     543 ..     432     543 .. 0.76

  Alignments for each domain:
  == domain 1  score: 26.4 bits;  conditional E-value: 2.9e-09
                 EEEEESTTSSHHHHHHHHHTSTEEESSSTTSSSSEEEEEEE..ETT.EEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETT.TTCSHHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltgekaivsdkpgtTrdinegrvk..lkg.keielvDtpGliegaseekglgkaflaleeadlillvvdas.eeklkpldee 96 
                 ++++G   +GK+t++n+          +pg+T+ ++ ++v+  ++g  ei ++D+ G  e++++ +++ k++l+  ++d il+v+d++ ++ l++   +
  EFC39624.1 433 FLLLGLDSSGKTTILNQFKS------GEPGVTTPTIGFNVEtlERGtAEICIWDIGG-NEKNRSPQKVWKHYLS--NTDCILFVLDSNdRQRLQEATDD 522
                 5789************9964......57777777777777665344599********.8877777788888886..689*******7773357777788 PP

                 HHHHHHH...TTSEEEEEEES CS
    MMR_HSR1  97 leellee...akkplilvlnk 114
                 l+++l++   ++ p+++ +nk
  EFC39624.1 523 LNRILKDdelKNCPILVFANK 543
                 888876666677777777776 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.1      0.12   2.4e+02       4      18 ..     436     450 ..     433     462 .. 0.85
   2 ?    9.0   0.0   0.00068       1.4     101     157 ..     474     530 ..     456     543 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.12
                 EEBTTTTHHHHHHHH CS
   Dynamin_N   4 vGsqSsGKSSvlnaL 18 
                 +G  SsGK+++ln+ 
  EFC39624.1 436 LGLDSSGKTTILNQF 450
                 6778*********85 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00068
                 -SEEEEE---B-SSSGTTSHHHHHHHSTTEEEEEEEETTS-CCC-.CHHHHHHHHSTT CS
   Dynamin_N 101 kgltlvDlPGldsvnkrdqelvkeyikkadiilavtsanhdlsns.ealflarevdpk 157
                  ++ + D  G    n   q++ k+y+ + d il+v+++n     +   ++l+r ++++
  EFC39624.1 474 AEICIWDIGGNE-KNRSPQKVWKHYLSNTDCILFVLDSNDRQRLQeATDDLNRILKDD 530
                 556666765544.577777********************9776662344555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (617 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       701  (0.0390987); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 3642.40
//
Query:       EFC39625.1  [L=286]
Description: FBOX domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0002   21.2   0.0    0.00043   20.1   0.0    1.5  1  F-box-like  F-box-like
    0.00027   20.7   0.1    0.00069   19.4   0.0    1.7  2  F-box       F-box domain


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.0   4.8e-08   0.00043       5      39 ..      63      97 ..      62      98 .. 0.95

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 4.8e-08
  F-box-like  5 PdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtp 39
                PdE+  +I+ yLp +  ++++ V++++rrv  +tp
  EFC39625.1 63 PDEVVKEILNYLPSECTISVSSVSKQFRRVWKNTP 97
                9*****************************98886 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   7.7e-08   0.00069       7      39 ..      63      95 ..      63      98 .. 0.96
   2 ?   -3.5   0.0       1.2   1.1e+04      10      20 ..     246     256 ..     236     256 .. 0.73

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 7.7e-08
                -HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHTT CS
       F-box  7 PsevlrhILerLplsdllalrrVSkgwrilids 39
                P+ev+++IL +Lp    ++ ++VSk +r+++++
  EFC39625.1 63 PDEVVKEILNYLPSECTISVSSVSKQFRRVWKN 95
                9*****************************986 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.2
                 HHHHHHHTS-H CS
       F-box  10 vlrhILerLpl 20 
                 ++++ ++++++
  EFC39625.1 246 IIEKAISYMDP 256
                 88999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (286 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       855  (0.0476881); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 1626.30
//
Query:       EFC39626.1  [L=274]
Description: FBOX domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    9.4e-05   22.2   0.0    0.00021   21.1   0.0    1.6  1  F-box       F-box domain
     0.0055   16.6   0.0      0.015   15.1   0.0    1.6  2  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.065   13.1   0.1        1.2    9.1   0.0    2.3  2  F-box_4     F-box


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.1   0.0   3.5e-08   0.00021       7      38 ..      54      85 ..      54      88 .. 0.97

  Alignments for each domain:
  == domain 1  score: 21.1 bits;  conditional E-value: 3.5e-08
                -HHHHHHHHHTS-HHHHHHHCTT-HHHHHHHT CS
       F-box  7 PsevlrhILerLplsdllalrrVSkgwrilid 38
                P+e++++IL +++ ++ + +++VS  +r++++
  EFC39626.1 54 PDEIIEQILNFMNYKSSIQASSVSQQFRRAWK 85
                9****************************997 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   0.0   2.6e-06     0.015       5      38 ..      54      87 ..      53      89 .. 0.93
   2 ?   -2.8   0.0         1   6.1e+03      25      29 ..     183     187 ..     179     188 .. 0.84

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 2.6e-06
  F-box-like  5 PdEiLlqIFsyLppsdLlrlalVCrrWrrvaldt 38
                PdEi+ qI+ +++ ++ ++++ V+ ++rr+   t
  EFC39626.1 54 PDEIIEQILNFMNYKSSIQASSVSQQFRRAWKQT 87
                9****************************97666 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1
  F-box-like  25 alVCr 29 
                 +lVC+
  EFC39626.1 183 TLVCK 187
                 89**9 PP

>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.0   0.00019       1.2       5      53 ..      50      96 ..      46     124 .. 0.75
   2 ?    1.5   0.0     0.045   2.7e+02      66      94 ..     153     181 ..     140     192 .. 0.83

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00019
     F-box_4  5 LssLPlevlqhiaslLDsfsLsqLslvskllrevcssllqergiVllkW 53
                L s P e++++i++++   s +q s vs+++r   +++   +giV  + 
  EFC39626.1 50 LGSQPDEIIEQILNFMNYKSSIQASSVSQQFRRAWKQT--PHGIVYTMV 96
                6788***************************9865553..455655555 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.045
     F-box_4  66 kikkkvwefstlfskvksWkfedvsslse 94 
                 k+kk+  +fs+++sk++ + +e +s++  
  EFC39626.1 153 KTKKQSENFSNAISKITGFDYERTSKMDY 181
                 66778889**************9999965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (274 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       907  (0.0505884); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.53
# Mc/sec: 1544.72
//
Query:       EFC39627.1  [L=591]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.2e-69  231.4  32.4    5.7e-37  127.3  13.0    2.3  2  Chromate_transp  Chromate transporter
  ------ inclusion threshold ------
       0.11   12.5   1.1       0.26   11.2   1.1    1.6  1  Flavi_NS4A       Flavivirus non-structural protein NS4A
        7.6    6.9  16.3        5.8    7.3   0.0    4.6  5  Phage_holin_5_2  Phage holin family Hol44, in holin superfami


Domain annotation for each model (and alignments):
>> Chromate_transp  Chromate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  109.8  11.4   2.3e-35   1.4e-31       1     153 [.      94     260 ..      94     265 .. 0.83
   2 !  127.3  13.0   9.5e-41   5.7e-37       3     155 ..     420     581 ..     418     583 .. 0.90

  Alignments for each domain:
  == domain 1  score: 109.8 bits;  conditional E-value: 2.3e-35
  Chromate_transp   1 lelflfflkiGllifGGgyavipllreevverkgwlteeefldglalaqalPGPiavnlatfvGylilgvlGaliatlgfflPsfllilllapl 94 
                      +++ ++++ +Gll+fGG+ a+i++l+e +v++++w+t e+f++++a++q+lPGP++++l++ +G   +g lG+l+++++f lP +++++ +  l
       EFC39627.1  94 WDITSSMIPLGLLSFGGPAAHISILQENFVTKRQWVTLEQFTELFAVCQSLPGPTSTQLVIALGTIHAGYLGGLLSFIFFALPTAIIMACAGVL 187
                      567889999***********************99*******************************955*************************9 PP

  Chromate_transp  95 lek..lrk..nplvkaaleglnaavvglilaaalslakk.........iallaflllllfkvs.pilvillaa 153
                      l+   + +    ++k al+g  +a+v ++l+aa++l ++         ++++af++ ++++ +  +l++++++
       EFC39627.1 188 LKDqnVTEmfPYYLKVALNGFSCAAVSIVLHAAYTLSSRlttdrisrtLLIAAFAVFIIWQKWyTVLIVMFCG 260
                      999442224334599*******************765557778888875566666655555554444444443 PP

  == domain 2  score: 127.3 bits;  conditional E-value: 9.5e-41
  Chromate_transp   3 lflfflkiGllifGGgyavipllreevverkgwlteeefldglalaqalPGPiavnlatfvGylil.gvlGaliatlgfflPsfllilllapll 95 
                       ++ f++iG+lifGGg++v+p++ +e+ e  g+lte+ fl+g+al  alPGP++ n++++vG   +  v+Ga+i+++++flP+fl++ +++p++
       EFC39627.1 420 WAEGFYRIGSLIFGGGHVVLPMILNEFSE-LGYLTEDSFLNGFALQSALPGPMF-NISAYVGGI-MgDVVGAVICWVALFLPAFLFVWGALPFW 510
                      5678***********************99.78*********************9.********9.559************************** PP

  Chromate_transp  96 eklrknplvkaaleglnaavvglilaaalslakk...........iallaflllllfkvspilvillaall 155
                      +++r++++vk++l+g+na++vg++++a++ l+              +++++l+l +++++  lvil+a+++
       EFC39627.1 511 HRYRQKQIVKSILKGVNATSVGFVFTAVYILWLGsvpnlhiasacTVVFSILMLSVYDIPAPLVILAAGAI 581
                      ***99************************664447788998888867888889999999955677777665 PP

>> Flavi_NS4A  Flavivirus non-structural protein NS4A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   1.1   4.4e-05      0.26      72     115 ..     524     566 ..     518     574 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4.4e-05
  Flavi_NS4A  72 kGlsktsialltviassallflasvkpthiaavillef.vlmvll 115
                 kG++ ts++   v ++ ++l+l+sv   hia +  + f +lm+ +
  EFC39627.1 524 KGVNATSVG--FVFTAVYILWLGSVPNLHIASACTVVFsILMLSV 566
                 677777766..577899************9876655542677554 PP

>> Phage_holin_5_2  Phage holin family Hol44, in holin superfamily V
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.0   0.00096       5.8       6      49 ..      85     127 ..      83     144 .. 0.77
   2 ?    1.2   0.9     0.076   4.6e+02      32      71 ..     179     220 ..     152     222 .. 0.63
   3 ?    6.7   0.4    0.0015       9.1      19      46 ..     248     275 ..     236     283 .. 0.83
   4 ?   -1.3   0.3      0.47   2.8e+03      29      41 ..     485     497 ..     474     538 .. 0.54
   5 ?   -2.1   0.2      0.82   4.9e+03      30      52 ..     531     554 ..     526     581 .. 0.56

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.00096
  Phage_holin_5_2   6 yiiGeilKktekvkdkyIPlilgiiGiilgvvivftadfqaedi 49 
                      +++G+ lK +  + + +IPl l+ +G+  + + ++  +f  +  
       EFC39627.1  85 FFLGYLLKLWD-ITSSMIPLGLLSFGGPAAHISILQENFVTKRQ 127
                      689*******7.***************99977666644443333 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.076
  Phage_holin_5_2  32 iilgvvivfta..dfqaedilifg.....aiiqGilsggastglnQl 71 
                      ii++ ++v+++  ++ +             ++ G+ ++++s+ l+ +
       EFC39627.1 179 IIMACAGVLLKdqNVTEM-----FpyylkVALNGFSCAAVSIVLHAA 220
                      333333333321333333.....134455999999999999999865 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.0015
  Phage_holin_5_2  19 kdkyIPlilgiiGiilgvvivftadfqa 46 
                      +++y +li++++G++++vv  +t++f +
       EFC39627.1 248 QKWYTVLIVMFCGGFINVVFEYTQIFYQ 275
                      679**************99999975554 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.47
  Phage_holin_5_2  29 iiGiilgvvivft 41 
                      ++G++++ v++f+
       EFC39627.1 485 VVGAVICWVALFL 497
                      4555555444444 PP

  == domain 5  score: -2.1 bits;  conditional E-value: 0.82
  Phage_holin_5_2  30 iGiilgvvivfta.dfqaedilif 52 
                      +G ++++v++++  ++++  i+ +
       EFC39627.1 531 VGFVFTAVYILWLgSVPNLHIASA 554
                      566666666555445555444442 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (591 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1269  (0.0707792); expected 358.6 (0.02)
Passed bias filter:                      571  (0.0318478); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 3369.51
//
Query:       EFC39628.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.3e-18   64.5   0.1    3.2e-11   43.0   0.0    2.4  3  adh_short     short chain dehydrogenase
    4.9e-13   49.2   0.0    2.4e-05   24.0   0.0    2.4  3  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
  ------ inclusion threshold ------
      0.026   13.8   0.0      0.041   13.1   0.0    1.2  1  Pho88         Phosphate transport (Pho88)
      0.054   13.0   1.1      0.087   12.3   0.3    1.9  2  ANAPC4        Anaphase-promoting complex, cyclosome, subunit 
       0.11   12.4   0.0       0.27   11.1   0.0    1.6  2  KR            KR domain


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.0   0.0     9e-15   3.2e-11       1      93 [.      25     120 ..      25     130 .. 0.91
   2 ?   -3.2   0.0       1.4   4.9e+03      91     124 ..     199     232 ..     196     240 .. 0.73
   3 !   19.0   0.0   2.1e-07   0.00077     131     186 ..     257     316 ..     243     322 .. 0.83

  Alignments for each domain:
  == domain 1  score: 43.0 bits;  conditional E-value: 9e-15
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT...TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSG CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee...gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpf 93 
                 k+++vtG+   IG+++a  l++ Gakv+v+ r ++++    k++k+     +++l+++++++d ++v ++ + ++k+++++++L+nNA+ t ++p 
  EFC39628.1  25 KAAIVTGGRIKIGLQTALVLLRLGAKVIVTTRFASDALLKFKKCKDFsewYDRLLIYPLNLKDGKSVIDFTQYIKKNFKQIHILINNAAQTVKRPL 120
                 789**************************999999998888999987667899***********************************99777665 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 1.4
                 SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHH CS
   adh_short  91 gpfselseeewervievNltgvflltravlpaml 124
                 ++ s++s +e+ ++  +N +++  l+ ++++ m+
  EFC39628.1 199 EKLSDVSVTEIVESQMINTVSPTILASELFEIMK 232
                 5667777777777777888888888888877776 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 2.1e-07
                 EEEEEEGGGTSB-TTBH....HHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEESSBSSHH CS
   adh_short 131 IvnvsSvagkvpvagva....aYsAsKaavagltrslakelaptgirvnavaPGlvdTdm 186
                 I+nv+S  g+ +  g +       +sKa +++ltrs ++ +a+ gi vn+v +G v++++
  EFC39628.1 257 IINVTSHEGQFETSGKSdshiQTNTSKASLNMLTRSCSEYYARNGILVNSVDTGWVSSAL 316
                 999999999776655431111678*******************************99876 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.0   6.8e-09   2.4e-05       6      82 ..      36     117 ..      33     144 .. 0.83
   2 ?   -3.3   0.0       1.5   5.3e+03      87     118 ..     201     232 ..     195     235 .. 0.71
   3 !   22.6   0.0   1.8e-08   6.6e-05     122     178 ..     256     316 ..     246     338 .. 0.78

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 6.8e-09
                   HHHHHHHHHHHTT-EEEEEESSGGH....HHHHHHHHHHTTSE.EEE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EG CS
  adh_short_C2   6 IGraiAkalaeeGaevvltdlneea....kkrveelaeelgae.vlecDVtdeeqvealveevvekfgklDilvnnagiapk 82 
                   IG ++A  l + Ga+v++t +  ++     k+++++ e +++  +++++ +d ++v ++ + ++++f++++il+nna+ + k
    EFC39628.1  36 IGLQTALVLLRLGAKVIVTTRFASDallkFKKCKDFSEWYDRLlIYPLNLKDGKSVIDFTQYIKKNFKQIHILINNAAQTVK 117
                   9****************9987554433534777777777777756*********************************9887 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.5
                   GGGH-HHHHHHHHHHHTHHHHHHHHHHHHHCT CS
  adh_short_C2  87 fletsreefdraldvnlyslfllakaalplmk 118
                   + ++s  e+ + + +n+ s + la ++ ++mk
    EFC39628.1 201 LSDVSVTEIVESQMINTVSPTILASELFEIMK 232
                   56677777777777888888877777777776 PP

  == domain 3  score: 22.6 bits;  conditional E-value: 1.8e-08
                   EEEEEEEGGGTSBSTTTT....HHHHHHHHHHHHHHHHHHHHGGGTEEEEEEEE--BHCTG CS
  adh_short_C2 122 sivnlssvgaervvpnyn....aygaaKaalealtrylAvelgpkgiRvNavspgpikTla 178
                    i+n++s  ++  +++ +      +++Ka+l+ ltr++   ++++gi vN+v  g++   +
    EFC39628.1 256 FIINVTSHEGQFETSGKSdshiQTNTSKASLNMLTRSCSEYYARNGILVNSVDTGWVSSAL 316
                   58999999887665554444567899*******************************9765 PP

>> Pho88  Phosphate transport (Pho88)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.0   1.2e-05     0.041     123     164 ..      90     134 ..      81     152 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1.2e-05
       Pho88 123 simplknllesnlvkihllgkpaegdLkRPFkaaagllgaa...e 164
                 s++ + + +++n  +ih+l ++a   +kRP +  ++ll++     
  EFC39628.1  90 SVIDFTQYIKKNFKQIHILINNAAQTVKRPLEYYKSLLKSEqkyL 134
                 89999999*************************999996532232 PP

>> ANAPC4  Anaphase-promoting complex, cyclosome, subunit 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       0.8   2.9e+03     172     194 ..      53      75 ..      42      80 .. 0.74
   2 ?   12.3   0.3   2.4e-05     0.087      28      68 ..      92     136 ..      89     263 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.8
      ANAPC4 172 kaeellqviseelkqfkaFinWl 194
                 + +++ +++    k++k+F++W 
  EFC39628.1  53 VTTRFASDALLKFKKCKDFSEWY 75 
                 56667777777788999999996 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 2.4e-05
      ANAPC4  28 qslleyinetlkeiseewkealelldrklrnledelkeeg....e 68 
                  + ++yi++++k+i+  +++a ++  r l+ ++++lk+e+    +
  EFC39628.1  92 IDFTQYIKKNFKQIHILINNAAQTVKRPLEYYKSLLKSEQkyltK 136
                 6789**********************************9955541 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   7.5e-05      0.27       4      97 ..      28     120 ..      26     126 .. 0.83
   2 ?   -3.4   0.0       2.1   7.5e+03     145     162 ..     187     204 ..     186     216 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 7.5e-05
                 EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE---------T CS
          KR   4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvlrdkll 97 
                 ++tGG  ++Gl++a  l++ ga+ + +++R a+    + ++ + +++   +  ++++ + d ++v    + ik+++++i+  i+ A  + +++l
  EFC39628.1  28 IVTGGRIKIGLQTALVLLRLGAKVI-VTTRFASDALLKFKKCKDFSEWYDRLLIYPLNLKDGKSVIDFTQYIKKNFKQIHILINNAAQTVKRPL 120
                 89*******************9865.56787666666667888888888899999999999999999999999999999999998887766666 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.1
                 T-HHHHHHHHHHHHHHHH CS
          KR 145 gqanYaaaNaflDalaey 162
                 +q++Y  +N++ + l + 
  EFC39628.1 187 EQVDYRPTNSWNEKLSDV 204
                 589999999998888665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       688  (0.0383736); expected 358.6 (0.02)
Passed bias filter:                      421  (0.0234815); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.34s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2055.33
//
Query:       EFC39629.1  [L=370]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.9e-69  227.2  18.3    4.2e-11   43.1   0.3    7.9  8  Sel1      Sel1 repeat
    5.5e-06   26.4  10.4       0.92   10.0   0.1    5.8  6  TPR_17    Tetratricopeptide repeat
      0.001   19.6   1.4        5.1    8.0   0.0    4.3  5  TPR_6     Tetratricopeptide repeat
     0.0075   16.5  11.7      0.059   13.7   0.0    5.8  7  TPR_12    Tetratricopeptide repeat
     0.0091   15.8   0.2     0.0091   15.8   0.2    8.1  9  TPR_1     Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.062   13.4   0.1      0.062   13.4   0.1    7.8 10  TPR_2     Tetratricopeptide repeat
       0.23   11.4  13.8         14    5.7   0.0    5.9  7  TPR_10    Tetratricopeptide repeat
       0.36   11.1   5.5         55    4.1   4.1    3.6  2  ANAPC3    Anaphase-promoting complex, cyclosome, subunit 3
        8.4    6.2  26.9        2.8    7.7   2.7    6.2  6  TPR_11    TPR repeat


Domain annotation for each model (and alignments):
>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.7   0.2   5.2e-13     1e-09       2      38 .]      82     116 ..      81     116 .. 0.94
   2 !   42.3   0.0   3.8e-14   7.5e-11       1      38 []     117     152 ..     117     152 .. 0.97
   3 !   20.1   0.2   3.7e-07   0.00075       2      38 .]     154     184 ..     153     184 .. 0.85
   4 !   30.0   1.0   2.9e-10   5.8e-07       1      38 []     185     220 ..     185     220 .. 0.94
   5 !   39.4   0.0   3.2e-13   6.3e-10       2      37 ..     222     255 ..     221     256 .. 0.93
   6 ?   -0.9   0.0       1.5     3e+03      28      38 .]     276     286 ..     275     286 .. 0.89
   7 !   43.1   0.3   2.1e-14   4.2e-11       2      38 .]     288     322 ..     287     322 .. 0.93
   8 !   19.3   0.0   6.9e-07    0.0014       3      32 ..     325     353 ..     324     354 .. 0.90

  Alignments for each domain:
  == domain 1  score: 38.7 bits;  conditional E-value: 5.2e-13
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  A+++LG   +y+nG+gv+ D++kA++wyek+Aeq++
  EFC39629.1  82 IAQNNLG--AAYQNGTGVDIDYKKAVYWYEKSAEQNN 116
                 69*****..777***********************86 PP

  == domain 2  score: 42.3 bits;  conditional E-value: 3.8e-14
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +eA+++LG  yly++Glgvpk++e A++++ek+A+q++
  EFC39629.1 117 SEAQFNLG--YLYQEGLGVPKNIEIALQFFEKSANQNH 152
                 79******..999***********************98 PP

  == domain 3  score: 20.1 bits;  conditional E-value: 3.7e-07
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                  A+++LG     ++      D++kA++w++kA ++G+
  EFC39629.1 154 KAQNNLG--V--QYLA--IGDKSKALYWFKKASDNGY 184
                 5888999..7..7775..77**************996 PP

  == domain 4  score: 30.0 bits;  conditional E-value: 2.9e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 a A+y+LG fy    G+ v+k+p  A+ wy k+Ae G+
  EFC39629.1 185 AKAQYNLGGFY--ARGDAVEKNPFTAFDWYLKSAEGGY 220
                 68******888..***99*****************985 PP

  == domain 5  score: 39.4 bits;  conditional E-value: 3.2e-13
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                 ++++++G   +y+nG gv++D++ +i+w+ekAA+qG
  EFC39629.1 222 HSQHNVG--IMYFNGIGVKQDYQIGIQWLEKAASQG 255
                 79*****..777***********************9 PP

  == domain 6  score: -0.9 bits;  conditional E-value: 1.5
        Sel1  28 ewyekAAeqGd 38 
                  w+e+ A++Gd
  EFC39629.1 276 NWLEQLANKGD 286
                 6*******997 PP

  == domain 7  score: 43.1 bits;  conditional E-value: 2.1e-14
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqGd 38 
                 +A+++LG   +y  G+gv+ D+ kAi+w++kAA+qG+
  EFC39629.1 288 SAQNNLG--AMYNMGTGVKEDKAKAIYWLQKAADQGN 322
                 8******..666************************7 PP

  == domain 8  score: 19.3 bits;  conditional E-value: 6.9e-07
        Sel1   3 AmyrLGmfylylnGl.gvpkDpekAiewyek 32 
                 ++++LG   +ylnG  gvpkD ekA+ ++ k
  EFC39629.1 325 SLFNLG--AIYLNGGeGVPKDLEKARSLFSK 353
                 689***..666****99**********9987 PP

>> TPR_17  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0      0.21   4.2e+02       8      25 ..      76      93 ..      74     105 .. 0.83
   2 !    8.7   0.1    0.0012       2.5       2      24 ..     108     128 ..     107     136 .. 0.86
   3 !   10.0   0.1   0.00046      0.92       4      33 ..     146     173 ..     143     174 .. 0.86
   4 ?   -1.3   0.1         2   3.9e+03      12      23 ..     184     195 ..     179     204 .. 0.69
   5 ?   -0.6   0.0       1.1   2.3e+03       9      24 ..     283     298 ..     278     311 .. 0.70
   6 !    7.1   0.0    0.0039       7.8       9      27 ..     319     337 ..     314     349 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.21
      TPR_17  8 ldPnnadaynnLAelllk 25
                 d  ++ a nnL+ ++ +
  EFC39629.1 76 ADTGDSIAQNNLGAAYQN 93
                57789999******9985 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.0012
      TPR_17   2 ylkaleldPnnadaynnLAelll 24 
                 y+k++  + nn++a +nL++l+ 
  EFC39629.1 108 YEKSA--EQNNSEAQFNLGYLYQ 128
                 66666..88************96 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00046
      TPR_17   4 kaleldPnnadaynnLAelllknGdlmtAr 33 
                 k++  + n+++a nnL++ +l +Gd+ +A+
  EFC39629.1 146 KSA--NQNHVKAQNNLGVQYLAIGDKSKAL 173
                 555..99******************99886 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 2
      TPR_17  12 nadaynnLAell 23 
                 +a+a +nL+ ++
  EFC39629.1 184 YAKAQYNLGGFY 195
                 566667776555 PP

  == domain 5  score: -0.6 bits;  conditional E-value: 1.1
      TPR_17   9 dPnnadaynnLAelll 24 
                 ++ ++ a nnL+  + 
  EFC39629.1 283 NKGDVSAQNNLGAMYN 298
                 5667777788877664 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.0039
      TPR_17   9 dPnnadaynnLAelllknG 27 
                 d  n ++++nL+ ++l+ G
  EFC39629.1 319 DQGNDNSLFNLGAIYLNGG 337
                 78899***********977 PP

>> TPR_6  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.0   0.0    0.0025       5.1       1      25 [.     118     146 ..     118     150 .. 0.89
   2 ?   -1.1   0.0       1.9   3.8e+03       6      20 ..     159     173 ..     158     179 .. 0.83
   3 ?   -3.2   0.1       8.9   1.8e+04       2      10 ..     187     195 ..     185     200 .. 0.64
   4 ?   -1.8   0.0       3.2   6.3e+03       3      21 ..     296     310 ..     293     312 .. 0.46
   5 !    6.9   0.0    0.0056        11       2      26 ..     325     354 ..     324     356 .. 0.90

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.0025
                 HHHHHHHHHHHHH....HHHHHHHHHHHH CS
       TPR_6   1 dAlyklalsyrkl....gdtdkAlealer 25 
                 +A+++l+++y+++    ++ + Al+ +e+
  EFC39629.1 118 EAQFNLGYLYQEGlgvpKNIEIALQFFEK 146
                 79**********66999999999999987 PP

  == domain 2  score: -1.1 bits;  conditional E-value: 1.9
                 HHHHHHHHHHHHHHH CS
       TPR_6   6 lalsyrklgdtdkAl 20 
                 l+  y++ gd++kAl
  EFC39629.1 159 LGVQYLAIGDKSKAL 173
                 788899978999996 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 8.9
                 HHHHHHHHH CS
       TPR_6   2 Alyklalsy 10 
                 A+y+l+  y
  EFC39629.1 187 AQYNLGGFY 195
                 777777555 PP

  == domain 4  score: -1.8 bits;  conditional E-value: 3.2
                 HHHHHHHHHHHH.HHHHHHH CS
       TPR_6   3 lyklalsyrklg.dtdkAle 21 
                 +y+++      g + dkA++
  EFC39629.1 296 MYNMGT-----GvKEDKAKA 310
                 444432.....334455555 PP

  == domain 5  score: 6.9 bits;  conditional E-value: 0.0056
                 HHHHHHHHHHHH.....HHHHHHHHHHHHH CS
       TPR_6   2 Alyklalsyrkl.....gdtdkAlealerl 26 
                 +l++l+  y+++     +d +kA+ ++ ++
  EFC39629.1 325 SLFNLGAIYLNGgegvpKDLEKARSLFSKI 354
                 69*********77**************987 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.3   0.3     0.024        49      44      73 ..      80     113 ..      66     117 .. 0.70
   2 ?    3.5   0.3     0.044        87      59      73 ..      96     113 ..      79     130 .. 0.62
   3 !   13.7   0.0     3e-05     0.059      29      72 ..     140     180 ..     135     182 .. 0.83
   4 ?   -2.4   0.0         3   6.1e+03       3      15 ..     185     197 ..     183     199 .. 0.77
   5 ?   -3.3   0.0       5.9   1.2e+04      17      30 ..     239     252 ..     238     254 .. 0.80
   6 ?    0.2   0.1      0.47   9.3e+02      59      71 ..     305     317 ..     279     320 .. 0.57
   7 ?   -1.0   0.0       1.1   2.3e+03      25      46 ..     343     364 ..     342     367 .. 0.65

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.024
      TPR_12  44 tattlrnLgrlyr.alg...ryeeAlelleeala 73 
                  +++++nLg +y+  +g   +y++A++++e++ +
  EFC39629.1  80 DSIAQNNLGAAYQnGTGvdiDYKKAVYWYEKSAE 113
                 5677778888875466677788999999988865 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.044
      TPR_12  59 g...ryeeAlelleeala 73 
                 g   +y++A++++e++ +
  EFC39629.1  96 GvdiDYKKAVYWYEKSAE 113
                 344466666666666644 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 3e-05
      TPR_12  29 aleiarrllGpdhpltattlrnLgrlyralgryeeAlelleeal 72 
                 al+ ++++ +    + + +++nLg  y+a g+  +Al+++++a 
  EFC39629.1 140 ALQFFEKSANQ---NHVKAQNNLGVQYLAIGDKSKALYWFKKAS 180
                 77777777444...5689************************96 PP

  == domain 4  score: -2.4 bits;  conditional E-value: 3
      TPR_12   3 atalnnlaavlrr 15 
                 a+a++nl+ +++r
  EFC39629.1 185 AKAQYNLGGFYAR 197
                 6788899988865 PP

  == domain 5  score: -3.3 bits;  conditional E-value: 5.9
      TPR_12  17 grydeAlellekal 30 
                 ++y+  +++leka 
  EFC39629.1 239 QDYQIGIQWLEKAA 252
                 68888999999986 PP

  == domain 6  score: 0.2 bits;  conditional E-value: 0.47
      TPR_12  59 gryeeAlelleea 71 
                 ++ ++A+++l++a
  EFC39629.1 305 EDKAKAIYWLQKA 317
                 3556666666665 PP

  == domain 7  score: -1.0 bits;  conditional E-value: 1.1
      TPR_12  25 llekaleiarrllGpdhpltat 46 
                  leka+ +++++ +p+   +a+
  EFC39629.1 343 DLEKARSLFSKIKNPETKKAAE 364
                 4677777777777777666555 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1     0.076   1.5e+02       3      12 ..      83      92 ..      81      93 .. 0.85
   2 ?    3.0   0.2     0.048        96      16      31 ..     100     115 ..     100     118 .. 0.88
   3 ?    1.6   0.2      0.14   2.8e+02       2      12 ..     118     128 ..     117     129 .. 0.87
   4 ?   -0.8   0.0      0.81   1.6e+03      16      27 ..     136     147 ..     135     151 .. 0.84
   5 !   15.8   0.2   4.6e-06    0.0091       2      27 ..     154     179 ..     153     180 .. 0.96
   6 ?   -0.4   0.2      0.59   1.2e+03       1       8 [.     185     192 ..     185     197 .. 0.82
   7 ?    0.2   0.1      0.38   7.6e+02       3      11 ..     289     297 ..     287     299 .. 0.84
   8 ?   -2.1   0.5         2   4.1e+03      16      27 ..     306     317 ..     304     319 .. 0.82
   9 ?    3.0   0.2      0.05     1e+02       3      15 ..     325     337 ..     324     338 .. 0.82

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.076
                HHHHHHHHHH CS
       TPR_1  3 alynlGnayf 12
                a +nlG+ay+
  EFC39629.1 83 AQNNLGAAYQ 92
                789******7 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.048
                 -HHHHHHHHHHHHHHS CS
       TPR_1  16 kydeAleyyekALeln 31 
                 +y++A+  yek  e n
  EFC39629.1 100 DYKKAVYWYEKSAEQN 115
                 7**********98876 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.14
                 HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayf 12 
                 +a +nlG++y+
  EFC39629.1 118 EAQFNLGYLYQ 128
                 799*******7 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 0.81
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 + + Al+++ek 
  EFC39629.1 136 NIEIALQFFEKS 147
                 7788******95 PP

  == domain 5  score: 15.8 bits;  conditional E-value: 4.6e-06
                 HHHHHHHHHHHHTT-HHHHHHHHHHH CS
       TPR_1   2 kalynlGnayfklgkydeAleyyekA 27 
                 ka +nlG+ y+  g+  +Al  ++kA
  EFC39629.1 154 KAQNNLGVQYLAIGDKSKALYWFKKA 179
                 899**********************9 PP

  == domain 6  score: -0.4 bits;  conditional E-value: 0.59
                 HHHHHHHH CS
       TPR_1   1 akalynlG 8  
                 aka ynlG
  EFC39629.1 185 AKAQYNLG 192
                 89*****9 PP

  == domain 7  score: 0.2 bits;  conditional E-value: 0.38
                 HHHHHHHHH CS
       TPR_1   3 alynlGnay 11 
                 a +nlG++y
  EFC39629.1 289 AQNNLGAMY 297
                 889****99 PP

  == domain 8  score: -2.1 bits;  conditional E-value: 2
                 -HHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekA 27 
                 +  +A+   +kA
  EFC39629.1 306 DKAKAIYWLQKA 317
                 668999999998 PP

  == domain 9  score: 3.0 bits;  conditional E-value: 0.05
                 HHHHHHHHHHHTT CS
       TPR_1   3 alynlGnayfklg 15 
                 +l+nlG++y++ g
  EFC39629.1 325 SLFNLGAIYLNGG 337
                 689******9755 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.5     3e+03       3      12 ..      83      92 ..      81      93 .. 0.82
   2 ?    4.6   0.2     0.021        42      16      31 ..     100     115 ..     100     118 .. 0.90
   3 ?    1.0   0.1      0.31   6.2e+02       2      12 ..     118     128 ..     117     129 .. 0.87
   4 ?   -1.0   0.0       1.3   2.6e+03      16      28 ..     136     148 ..     135     151 .. 0.79
   5 ?   13.4   0.1   3.1e-05     0.062       2      27 ..     154     179 ..     153     181 .. 0.94
   6 ?   -2.1   0.1       2.9   5.8e+03       1      12 [.     185     196 ..     185     199 .. 0.76
   7 ?   -2.8   0.0       4.8   9.6e+03      15      28 ..     239     252 ..     238     253 .. 0.78
   8 ?    1.5   0.2       0.2   4.1e+02      15      29 ..     305     319 ..     304     324 .. 0.83
   9 ?    1.3   0.1      0.24   4.8e+02       3      15 ..     325     337 ..     323     338 .. 0.84
  10 ?   -1.0   0.0       1.3   2.6e+03      15      26 ..     342     353 ..     342     354 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.5
       TPR_2  3 alynlGlayy 12
                a +nlG ay 
  EFC39629.1 83 AQNNLGAAYQ 92
                789****996 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.021
       TPR_2  16 dyeeAleafekAleld 31 
                 dy++A+ ++ek+ e +
  EFC39629.1 100 DYKKAVYWYEKSAEQN 115
                 8**********99987 PP

  == domain 3  score: 1.0 bits;  conditional E-value: 0.31
       TPR_2   2 ealynlGlayy 12 
                 ea +nlG++y 
  EFC39629.1 118 EAQFNLGYLYQ 128
                 899******96 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.3
       TPR_2  16 dyeeAleafekAl 28 
                 + e Al++fek+ 
  EFC39629.1 136 NIEIALQFFEKSA 148
                 67889*****986 PP

  == domain 5  score: 13.4 bits;  conditional E-value: 3.1e-05
       TPR_2   2 ealynlGlayyklgdyeeAleafekA 27 
                 +a +nlG  y++ gd  +Al +f+kA
  EFC39629.1 154 KAQNNLGVQYLAIGDKSKALYWFKKA 179
                 7899*********************9 PP

  == domain 6  score: -2.1 bits;  conditional E-value: 2.9
       TPR_2   1 aealynlGlayy 12 
                 a+a ynlG  y+
  EFC39629.1 185 AKAQYNLGGFYA 196
                 688999996665 PP

  == domain 7  score: -2.8 bits;  conditional E-value: 4.8
       TPR_2  15 gdyeeAleafekAl 28 
                 +dy+  ++++ekA 
  EFC39629.1 239 QDYQIGIQWLEKAA 252
                 67888899999995 PP

  == domain 8  score: 1.5 bits;  conditional E-value: 0.2
       TPR_2  15 gdyeeAleafekAle 29 
                  d ++A+ +++kA  
  EFC39629.1 305 EDKAKAIYWLQKAAD 319
                 5889*********76 PP

  == domain 9  score: 1.3 bits;  conditional E-value: 0.24
       TPR_2   3 alynlGlayyklg 15 
                  l+nlG +y++ g
  EFC39629.1 325 SLFNLGAIYLNGG 337
                 59*******9866 PP

  == domain 10  score: -1.0 bits;  conditional E-value: 1.3
       TPR_2  15 gdyeeAleafek 26 
                 +d+e+A+ +f k
  EFC39629.1 342 KDLEKARSLFSK 353
                 588999999876 PP

>> TPR_10  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   0.4     0.014        28       4      14 ..      83      93 ..      82      94 .. 0.91
   2 ?   -1.5   0.0       1.3   2.7e+03      17      29 ..     100     112 ..      98     113 .. 0.85
   3 ?    5.7   0.0    0.0069        14       4      28 ..     155     179 ..     153     180 .. 0.94
   4 ?   -2.1   0.0         2   4.1e+03       2      13 ..     185     196 ..     185     199 .. 0.79
   5 ?    0.2   0.0      0.37   7.4e+02       4      14 ..     223     233 ..     221     233 .. 0.88
   6 ?    4.5   0.3     0.017        35       3      12 ..     288     297 ..     287     302 .. 0.88
   7 ?   -2.3   0.1       2.4   4.7e+03       7      16 ..     328     337 ..     325     339 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.014
      TPR_10  4 slnNLanalrq 14
                ++nNL++a+++
  EFC39629.1 83 AQNNLGAAYQN 93
                79*******86 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 1.3
      TPR_10  17 rydeAealleeal 29 
                 +y++A+ ++e++ 
  EFC39629.1 100 DYKKAVYWYEKSA 112
                 7899******985 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0069
      TPR_10   4 slnNLanalrqrgrydeAealleea 28 
                 ++nNL++ + + g+  +A+ ++++a
  EFC39629.1 155 AQNNLGVQYLAIGDKSKALYWFKKA 179
                 79******************99987 PP

  == domain 4  score: -2.1 bits;  conditional E-value: 2
      TPR_10   2 AsslnNLanalr 13 
                 A ++ NL+  + 
  EFC39629.1 185 AKAQYNLGGFYA 196
                 56899***9995 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.37
      TPR_10   4 slnNLanalrq 14 
                 s++N ++++++
  EFC39629.1 223 SQHNVGIMYFN 233
                 89*******85 PP

  == domain 6  score: 4.5 bits;  conditional E-value: 0.017
      TPR_10   3 sslnNLanal 12 
                 s++nNL++++
  EFC39629.1 288 SAQNNLGAMY 297
                 79*******9 PP

  == domain 7  score: -2.3 bits;  conditional E-value: 2.4
      TPR_10   7 NLanalrqrg 16 
                 NL++++ + g
  EFC39629.1 328 NLGAIYLNGG 337
                 9****98766 PP

>> ANAPC3  Anaphase-promoting complex, cyclosome, subunit 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   4.1     0.027        55       4      58 ..     100     155 ..      98     192 .. 0.67
   2 ?    2.5   0.0     0.088   1.7e+02       7      38 ..     309     338 ..     304     368 .. 0.64

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.027
                 -HHHHHHHHHHHH.HHH--HHHHHHHHHHHHHT....T-HHHHHHHHHCTSHHHC-HHH CS
      ANAPC3   4 nyknAiflaerllaaetespedayllAlclyln....gqykrAyellrkaklnskslgc 58 
                 +yk+A+ ++e+    e++++e+ + l++ + +     ++ + A+++++k+  n ++ ++
  EFC39629.1 100 DYKKAVYWYEKSA--EQNNSEAQFNLGYLYQEGlgvpKNIEIALQFFEKS-ANQNHVKA 155
                 6999999999998..88888888888888776422224455666666666.44455554 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.088
                 HHHHHHHHHH.HHH--HHHHHHHHHHHHHTT- CS
      ANAPC3   7 nAiflaerllaaetespedayllAlclylngq 38 
                 +Ai ++ ++   ++ ++++++ l+  +++ g+
  EFC39629.1 309 KAIYWLQKAA--DQGNDNSLFNLGAIYLNGGE 338
                 5666666666..77777777777777777665 PP

>> TPR_11  TPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1      0.06   1.2e+02      30      39 ..      83      92 ..      80      94 .. 0.85
   2 ?    7.7   2.7    0.0014       2.8       9      39 ..     100     128 ..     100     129 .. 0.86
   3 ?   -0.5   0.0      0.52     1e+03      25      42 .]     150     167 ..     149     167 .. 0.76
   4 ?    2.8   2.1     0.049        97       4      36 ..     163     193 ..     160     203 .. 0.83
   5 ?    0.6   0.1      0.23   4.7e+02      27      42 .]     286     300 ..     283     300 .. 0.79
   6 ?    5.0   0.5    0.0095        19      12      40 ..     309     335 ..     306     337 .. 0.80

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.06
      TPR_11 30 ayynLGlayy 39
                a +nLG+ay+
  EFC39629.1 83 AQNNLGAAYQ 92
                789******8 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0014
      TPR_11   9 kyeeAieaYkkAlkldPdnaeayynLGlayy 39 
                 +y++A+ +Y+k  +   +n ea +nLG++y+
  EFC39629.1 100 DYKKAVYWYEKSAEQ--NNSEAQFNLGYLYQ 128
                 6999*******9986..577999******98 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.52
      TPR_11  25 PdnaeayynLGlayykqG 42 
                 ++ + a +nLG+ y++ G
  EFC39629.1 150 QNHVKAQNNLGVQYLAIG 167
                 5667899****9887665 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.049
      TPR_11   4 yyeqGkyeeAieaYkkAlkldPdnaeayynLGl 36 
                 y + G+  +A+ ++kkA   d+ +a a ynLG 
  EFC39629.1 163 YLAIGDKSKALYWFKKAS--DNGYAKAQYNLGG 193
                 777888889999999997..8999999999995 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.23
      TPR_11  27 naeayynLGlayykqG 42 
                 +++a +nLG a+y++G
  EFC39629.1 286 DVSAQNNLG-AMYNMG 300
                 67899****.777666 PP

  == domain 6  score: 5.0 bits;  conditional E-value: 0.0095
      TPR_11  12 eAieaYkkAlkldPdnaeayynLGlayyk 40 
                 +Ai +++kA   d+ n + ++nLG++y++
  EFC39629.1 309 KAIYWLQKAA--DQGNDNSLFNLGAIYLN 335
                 6899999987..56677799****99985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (370 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       486  (0.0271069); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.54
# Mc/sec: 2064.93
//
Query:       EFC39630.1  [L=970]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    5.3e-57  193.6  28.5    5.3e-57  193.6  28.5    2.0  2  G-alpha       G-protein alpha subunit
    2.4e-44  151.7   0.2    9.9e-44  149.7   0.2    2.1  1  Pkinase       Protein kinase domain
    1.8e-26   93.0   0.2    2.6e-24   85.9   0.2    2.5  1  Pkinase_Tyr   Protein tyrosine kinase
    1.7e-07   30.9   0.4    9.7e-07   28.4   0.4    2.2  2  Arf           ADP-ribosylation factor family
    0.00035   20.6   0.8       0.21   11.7   0.2    3.2  3  MMR_HSR1      50S ribosome-binding GTPase
     0.0013   18.1   3.4     0.0085   15.5   2.0    2.3  2  Gtr1_RagA     Gtr1/RagA G protein conserved region
     0.0058   17.1   1.2     0.0058   17.1   1.2    2.8  2  ABC_tran      ABC transporter
  ------ inclusion threshold ------
      0.028   13.9   0.5      0.074   12.6   0.2    2.0  2  GTP_EFTU      Elongation factor Tu GTP binding domain
      0.073   12.8   0.0       0.24   11.2   0.0    1.9  1  AAA_29        P-loop containing region of AAA domain
       0.12   12.3   0.0        0.2   11.6   0.0    1.3  1  APH           Phosphotransferase enzyme family
        3.5    8.1   6.3        7.1    7.1   0.5    3.4  3  RNA_helicase  RNA helicase


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  193.6  28.5   3.3e-60   5.3e-57      26     349 ..      28     549 ..      17     554 .. 0.79
   2 ?   -3.4   0.1       2.5   4.1e+03     156     166 ..     725     735 ..     633     764 .. 0.56

  Alignments for each domain:
  == domain 1  score: 193.6 bits;  conditional E-value: 3.3e-60
                 EEEEESTTSSHHHHHHHHHHHCS--.....--HHHHHC.CHHHHHHHHHHHHHHHHHHHHHT..T.................................. CS
     G-alpha  26 llllGqseSGKsTilkqlkllykkg.....fseeelat.wraviqlnivrsiktilealesl..eselsesf........................... 89 
                 + llG+seSGKsTi+k+ + ly+++     +s++e ++ ++  +q  iv++ik  ++ +e++  +++l   +                           
  EFC39630.1  28 VALLGTSESGKSTIFKSCRSLYGNAqfcnfHSTQENRIlIKTSLQYEIVHHIKRAIKFMEQFvaNNSLL--Sdnngssnaitsasreavsntsmpnler 124
                 789*******************9999***9899999999**********************74333332..2346777888888899999999999999 PP

                 ................................................................................................... CS
     G-alpha  90 ................................................................................................... 89 
                                                                                                                    
  EFC39630.1 125 kastrhdrrlsdelinlvksnpsqfsdrsilsnsfdenalgddsllgisavstamrhsklletssastsssglspsslgqsspltskttsndsqkpslf 223
                 999997777777777777777777777777777777777777777777666666666666666666555555555555555555555555555555554 PP

                 ............HHHC-SS-SCCCS-HCHHHH..........HHCCHHC-HCHHH............................................ CS
     G-alpha  90 ............elqelkerldplkkveasliaklssateeeqeiefnpraevge............................................ 132
                             +                                         +                                            
  EFC39630.1 224 nrgrttfandeiN-----------------------------------------Qqqqfdvnmnmsnenrrrnslissfqfewnkaeekivnrikfist 281
                 4444444332220.........................................133333333333333334444444444444444444444555555 PP

                 .....................HHHHHCCSHHHHHHHCCGCCTT..--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEEEEE CS
     G-alpha 133 .....................dikaLwndpgiqelyerrnkik..lednaeyFlddleritspdYlptddDilkarlktvGisetkfevdsklefrivd 208
                                      dika+w + +++ l+ + ++++  +++n+ yF+++++ri+++dY+pt+dD  k+r++t+Gi+ +++++++++ ++++d
  EFC39630.1 282 ktmnerswhidyegglkelksDIKAIWRNNAVRYLFMNATDFNfhISENIVYFMKNINRIFKEDYKPTEDDYFKMRVQTTGINSVDVKISKSTVVKVYD 380
                 555566666666666677777**************997777774367*******************************************9******** PP

                 E-SSHHHHHGTCCCT.TTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSE..EEEEEE-HHHHHHHCCCS..-GGGCCTT--... CS
     G-alpha 209 vgGqrserkkWvpff.ddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntp..iiLflnKlDileeKlkkg..klskyfpsye... 299
                 +gG r erkkW+ ++  + d+i+++vs+++fd +  +++++n+l+es+++ k++c++  ++n +  ++++lnK+D+++eK++++  ++s +fp++e   
  EFC39630.1 381 TGGERCERKKWALLLeAKPDVIVYVVSVADFDVNSCDQKNKNKLQESIEVLKSVCQEMNMRNLEseFVIVLNKMDVFKEKIEEKdkSISVIFPDFEkqg 479
                 ************9998899**************************************999876555***************66667************* PP

                 ....................H.CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHH CS
     G-alpha 300 ....................grkndlesvlkylrnkFeeihkeksnnrrkiythftsatdtkevqkvies 349
                                     + +n +++  ky+ + F +i++ + + +++i+++ +sa+d+  v+  +e+
  EFC39630.1 480 fhvsafttitastgginlstEPQNVFDNSRKYIGRLFYNIIRTELKSKKSIHMYEMSAIDKSFVKYLFEE 549
                 *******************7777779999*********************************99999976 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 2.5
                 -TTHHHHHCTH CS
     G-alpha 156 ednaeyFlddl 166
                   +++  ++++
  EFC39630.1 725 IQELNQNFNEI 735
                 11111112222 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  149.7   0.2   6.1e-47   9.9e-44       1     257 [.     687     960 ..     687     965 .. 0.85

  Alignments for each domain:
  == domain 1  score: 149.7 bits;  conditional E-value: 6.1e-47
                 EEEEEEEEEESSEEEEEEEETT..TTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEE.......................SSEEE CS
     Pkinase   1 yekleklGeGsfGkVykaveke..tgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfee.......................kdely 74 
                 y  ++++G G+ G  y + ek+  ++k +++K+ik + +++ ++   ++Eik l +l+h++i  + ++f e                       +  l+
  EFC39630.1 687 YAIKKRIGLGAQGAAYIVSEKDstEKKFYVMKRIKLRTIQELNQ--NFNEIKSLYSLRHEYINSIHDFFVEqkestiiadtigvgasesdagkqEYVLC 783
                 67899*********99987765115778***********99886..89**********************99********************8777778 PP

                 EEEE--TTEBHHHHHH.......HHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE..EEE-SGTTSEESSSSCSBCTTTSCGGG CS
     Pkinase  75 lvleyveggeladlle.......rkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge..lKitDFGlakelessskltsfvgtseY 163
                 ++le+++gg+l  +l        +++ +s++ + ++++++ ++l ++H kg +HrDlKpeNi+++ + +   l+i+DFGl++ ++s +  +  vgt+ Y
  EFC39630.1 784 IILEFCKGGDLRMYLDrfkkkngASSLVSQTLVVNWLRKLTAALVFIHTKGYLHRDLKPENIFFNdN-ERdeLRIGDFGLSCFVKSVE--NAKVGTECY 879
                 **********9888888877766666699999********************************953.3346**************88..999****** PP

                 S-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHH CS
     Pkinase 164 lAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaee 257
                 ++PE  k+++ys+++D+WslGvi++e+l++++    +++ +k+ + + +      i        + ++  see++d+++  l+ dp  R++ +e
  EFC39630.1 880 MSPEQAKGQDYSASSDIWSLGVIILEILSQRMTDV-KEELSKNPNFVSD------IC------NELKDIYSEELLDFVQMTLQLDPAARPSSSE 960
                 ***************************99887665.2222222222222......22......2334445********************9765 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   85.9   0.2   1.6e-27   2.6e-24       3     254 ..     689     960 ..     687     965 .. 0.78

  Alignments for each domain:
  == domain 1  score: 85.9 bits;  conditional E-value: 1.6e-27
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSS.......................EE CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeep.......................ll 77 
                  ++k++G Ga G  +  + k  +++++   ++K +k ++ +e  ++ ++e+k + +l+h+ i +++ + +++++                       l+
   EFC39630.1 689 IKKRIGLGAQGAAYIVSEK--DSTEKKFYVMKRIKLRTIQE-LNQNFNEIKSLYSLRHEYINSIHDFFVEQKEstiiadtigvgasesdagkqeyvLC 783
                  5678888888888877777..44444555578886666555.777778999999999999999999888555557888888888888889999999** PP

                  EEEE--TTEBHHHHHHHT.....CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETT..EEEE-STTTHEETTTSSEEEETTSSTSG CS
  Pkinase_Tyr  78 ivteyvkgGdLlkfLrkk.....ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenk..vvkisDfGLardiekddeyvkkeeaklp 168
                  i++e++kgGdL+ +L +      +++ ++ + ++++  ++ +++ ++++k ++Hrdl   N++ ++n+    +i+DfGL+  +      ++++ +   
   EFC39630.1 784 IILEFCKGGDLRMYLDRFkkkngASSLVSQTLVVNWLRKLTAALVFIHTKGYLHRDLKPENIFFNDNErdELRIGDFGLSCFV-----KSVENAKVGT 876
                  ***************98745554444556666789999**************************9865448************.....3334444555 PP

                  GGGS-HHHHHHSEEEHHHHHHHHHHHHHHHHTTSSGTTTTS..HHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHH CS
  Pkinase_Tyr 169 vkWmapEslkekkftsksDvWsfGvllwEiftlgespypgl..kneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfse 254
                    +m+pE  k + ++ +sD+Ws Gv++ Ei+++  + +++   kn ++++ + +    e  +  +eel ++++  ++ dp+ Rp+ se
   EFC39630.1 877 ECYMSPEQAKGQDYSASSDIWSLGVIILEILSQRMTDVKEElsKNPNFVSDICN----ELKDIYSEELLDFVQMTLQLDPAARPSSSE 960
                  68******************************8777766543455555555544....4456678999999999********998665 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0         1   1.6e+03      18      33 ..      29      44 ..      25      53 .. 0.86
   2 !   28.4   0.4   5.9e-10   9.7e-07      39     134 ..     354     463 ..     346     490 .. 0.78

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1
                EEEESTTSSHHHHHHH CS
         Arf 18 lllGLDnaGKtTilkk 33
                 llG  ++GK+Ti k 
  EFC39630.1 29 ALLGTSESGKSTIFKS 44
                57999********975 PP

  == domain 2  score: 28.4 bits;  conditional E-value: 5.9e-10
                 CEECSSSSSEEEEEEEE.TTEEEEEEEE-SSGGGGGGGGGGCT.TESEEEEEEETT-CT..........THHHHHHHHHHHCTSGCCT..TSEEEEEEE CS
         Arf  39 lvttvPTigfnveelei.knlkftvwDvGGqeklRplWknYfe.ktdavifvvDsadre..........RleeakeeLkalleeeelk..evallvlaN 123
                 ++  v T+g n+ +++i k   ++v+D GG++  R+ W   +e k d++++vv +ad +          +l+e+ e Lk++ +e +++  e  ++++ N
  EFC39630.1 354 FKMRVQTTGINSVDVKIsKSTVVKVYDTGGERCERKKWALLLEaKPDVIVYVVSVADFDvnscdqknknKLQESIEVLKSVCQEMNMRnlESEFVIVLN 452
                 5566789*********94556689***************998725799****965543222222223349***************99966689****** PP

                 -TTSTTSS-HH CS
         Arf 124 KqDlpealsee 134
                 K+D+ +   ee
  EFC39630.1 453 KMDVFKEKIEE 463
                 ***97655444 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   0.0    0.0077        13       2      19 ..      28      45 ..      27     149 .. 0.90
   2 !   11.7   0.2   0.00013      0.21      31     114 .]     358     453 ..     338     453 .. 0.64
   3 ?   -2.9   0.0       4.3     7e+03      44      62 ..     756     772 ..     742     791 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0077
                EEEEESTTSSHHHHHHHH CS
    MMR_HSR1  2 vaivGrpNvGKStLinal 19
                va++G + +GKSt++++ 
  EFC39630.1 28 VALLGTSESGKSTIFKSC 45
                89************9875 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 0.00013
                 TSSSSEEEEEEEETT.EEEEEEECGGCSSHHHHHHHHHHHHHHHHCT..SEEEEEEETT...........TTCSHHHHHHHHHHHHH.....TTSEEEE CS
    MMR_HSR1  31 gtTrdinegrvklkg.keielvDtpGliegaseekglgkaflaleea..dlillvvdas...........eeklkpldeeleellee.....akkplil 110
                   T+ in   vk+++ + ++++Dt G  e     + ++k+++ l ea  d+i++vv+++           ++kl++  e l+++ +e      + ++++
  EFC39630.1 358 VQTTGINSVDVKISKsTVVKVYDTGG--E-----RCERKKWALLLEAkpDVIVYVVSVAdfdvnscdqknKNKLQESIEVLKSVCQEmnmrnLESEFVI 449
                 5788999999998887889*******..4.....445566665555444*******9777777777654422333333333333333555556666788 PP

                 EEES CS
    MMR_HSR1 111 vlnk 114
                 vlnk
  EFC39630.1 450 VLNK 453
                 8887 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 4.3
                 TTEEEEEEECGGCSSHHHH CS
    MMR_HSR1  44 kgkeielvDtpGliegase 62 
                 ++++ +++Dt G +  ase
  EFC39630.1 756 QKESTIIADTIG-VG-ASE 772
                 446789999999.65.222 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.11   1.8e+02       2      29 ..      28      55 ..      27      90 .. 0.78
   2 !   15.5   2.0   5.2e-06    0.0085      33     131 ..     359     464 ..     337     488 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.11
   Gtr1_RagA  2 vLLmGksgsGKtsmrsiiFdnylardtl 29
                v L+G s+sGK+++ +   + y   +  
  EFC39630.1 28 VALLGTSESGKSTIFKSCRSLYGNAQFC 55
                5699*********987665555555555 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 5.2e-06
   Gtr1_RagA  33 atidveksevrflgnltlnlwDcgGqeafvee...ylssqkeeifrnvgvliyVfDve...........sreleedletlkeilealrqyspeakvfvl 117
                 +t+ ++  +v++++  ++++ D gG +   ++    l+ +        +v++yV+ v            +++l+e++e lk++ +++   + e ++ + 
  EFC39630.1 359 QTTGINSVDVKISKSTVVKVYDTGGERCERKKwalLLEAK-------PDVIVYVVSVAdfdvnscdqknKNKLQESIEVLKSVCQEMNMRNLESEFVIV 450
                 577899999****************998877733233333.......3455555433333344777654446*************************** PP

   Gtr1_RagA 118 ihKmDliqederee 131
                 ++KmD  +e+ +e+
  EFC39630.1 451 LNKMDVFKEKIEEK 464
                 *******9876654 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   1.2   3.6e-06    0.0058       7     110 ..      21     135 ..      17     260 .. 0.82
   2 ?   -2.3   0.0       3.6   5.8e+03      42      67 ..     449     474 ..     415     511 .. 0.66

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 3.6e-06
                 EEETTSEEEEEESTTSSHHHHHHHHTTSS--.........SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.....HHHTCHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxx RF
    ABC_tran   7 klkegekvaivGenGaGKStLlkllagllkp.........teGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.....esdeeiekalsk 91 
                 +++   +va++G + +GKSt++k    l+ +         +e +i l +++l+++  ++ ++ i++++q    ++ l   +n     + ++   +a+s+
  EFC39630.1  21 TIHTIPVVALLGTSESGKSTIFKSCRSLYGNaqfcnfhstQENRI-LIKTSLQYEIVHHIKRAIKFMEQFVANNSLL--SDNngssnAITSASREAVSN 116
                 6666779***************98777776666699999888888.55699******************93333333..33334445444445555555 PP

                 STTGGTTCBGESTTSGGS- CS
                 xxxxxxxxxxxxxxxxxxx RF
    ABC_tran  92 lglkelkdtvvksspssLS 110
                  ++++l+ +  +++++ LS
  EFC39630.1 117 TSMPNLERKASTRHDRRLS 135
                 5555555555444445554 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 3.6
                 EEETTCEGGGB-HHHCCHCEEEE-SS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  42 illdgkdlkeqeleslrkeigvlpqe 67 
                 i l++ d+ ++++e+ +k+i+v++ +
  EFC39630.1 449 IVLNKMDVFKEKIEEKDKSISVIFPD 474
                 34455555555666666666666555 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.5   2.4e+03       3      21 ..      25      43 ..      23      52 .. 0.82
   2 ?   12.6   0.2   4.6e-05     0.074     119     185 ..     436     547 ..     327     640 .. 0.73

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.5
                EEEEEEEESTTSSHHHHHH CS
    GTP_EFTU  3 irnigiighvDhGKtTLtd 21
                i  ++++g  ++GK+T+  
  EFC39630.1 25 IPVVALLGTSESGKSTIFK 43
                667899999*******975 PP

  == domain 2  score: 12.6 bits;  conditional E-value: 4.6e-05
                 HHTTTE.....EEEEEESCGSTHHHHHHHHHHHHHHHHHH.........................................HHHHHHHHHTTTTTEEEE CS
    GTP_EFTU 119 lkegvp.....iivfiNKmDrlkaelkeiveevkqklsrk.........................................eeklekygekgekevpvv 171
                 ++++++     +++++NKmD  k++++e  + ++  + +                                           + ++    ++ k ++++
  EFC39630.1 436 QEMNMRnleseFVIVLNKMDVFKEKIEEKDKSISVIFPDFekqgfhvsafttitastgginlstepqnvfdnsrkyigrlfYNIIRTELKSK-KSIHMY 533
                 33333333366***********9999999999998773335556666666666666666666666666666666555555333333333222.577777 PP

                 EEBTTTTBTHHHHH CS
    GTP_EFTU 172 fgSalkgegvktll 185
                  +Sa+++  vk l+
  EFC39630.1 534 EMSAIDKSFVKYLF 547
                 77777776655444 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   0.00015      0.24      24      42 ..      27      45 ..      15      60 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00015
      AAA_29 24 atlltGpsGsGKSTllDAi 42
                ++ l G+s+sGKST++ + 
  EFC39630.1 27 VVALLGTSESGKSTIFKSC 45
                6789***********8665 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   0.00012       0.2      70     185 ..     713     851 ..     695     864 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00012
                 EEEEEE----EE-SS.HHHHHHHHHHHHHHHHHHCCHHCH.-STTTB-...............................SHHCHTCCHHHHHHCHHHCC CS
         APH  70 lfalieyvpgrsllr.klsaaqlpellealgeflaalhqvdpaalpla...............................dflaqdlellrqlesatarl 136
                  f+++ ++  r++ + +++ ++++ l+   +e++  +h++  ++   +                               ++l+ +l+ + + + a   +
  EFC39630.1 713 KFYVMKRIKLRTIQElNQNFNEIKSLYSLRHEYINSIHDFFVEQKESTiiadtigvgasesdagkqeyvlciilefckgGDLRMYLDRFKKKNGA--SS 809
                 58888888888888888888888888888888888888884444444466666666666655555555555555555444443344444444444..44 PP

                 CGCCTCCHHHHHHHHHHHHHHHH--SSS-EEEE-SS-SGGGEEEC..TT CS
         APH 137 laselldlleeleeqvlaalaallpgelptvllHgDlhpgNllvdpddg 185
                 l s++l        ++l++l a l     ++ lH+Dl+p N+ ++ d+ 
  EFC39630.1 810 LVSQTLV-----V-NWLRKLTAALVFIHTKGYLHRDLKPENIFFN-DNE 851
                 4444444.....1.255555555555789****************.444 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1      0.12     2e+02       2      26 ..      29      52 ..      28     130 .. 0.76
   2 ?   -2.5   0.1       4.2   6.9e+03      55      87 ..     232     268 ..     214     277 .. 0.61
   3 ?    7.1   0.5    0.0044       7.1      52     101 ..     405     448 ..     403     452 .. 0.85

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.12
  RNA_helicase  2 wlyGpsgeGKStlakeLakallkkl 26
                   l G s  GKSt+ k+ +++l ++ 
    EFC39630.1 29 ALLGTSESGKSTIFKS-CRSLYGNA 52
                  5789**********99.88887554 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 4.2
  RNA_helicase  55 idDfgqvkdee...nps.dlaelirlvsstpyplnma 87 
                    d+++q+++     n s +    + l+ss++++ n+a
    EFC39630.1 232 NDEINQQQQFDvnmNMSnENRRRNSLISSFQFEWNKA 268
                   4555555533330233334444566777777776666 PP

  == domain 3  score: 7.1 bits;  conditional E-value: 0.0044
  RNA_helicase  52 vvvidDfgqvkdee.npsdlaelirlvsstpyplnmasleekgtlftSkvv 101
                   vv + Df  ++ ++ n++ l+e i++ +s+  ++nm +le+       ++v
    EFC39630.1 405 VVSVADFDVNSCDQkNKNKLQESIEVLKSVCQEMNMRNLES-------EFV 448
                   677889999997777999*********************94.......455 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (970 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1208  (0.0673769); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.90u 0.37s 00:00:01.27 Elapsed: 00:00:00.56
# Mc/sec: 5174.62
//
Query:       EFC39631.1  [L=128]
Description: hypothetical protein NAEGRDRAFT_81235 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.039   13.5   1.0       0.04   13.5   1.0    1.2  1  RAG1_imp_bd  RAG1 importin binding


Domain annotation for each model (and alignments):
>> RAG1_imp_bd  RAG1 importin binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   1.0   2.2e-06      0.04       3      82 ..       3      76 ..       1     123 [. 0.74

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.2e-06
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXXXXXX CS
  RAG1_imp_bd  3 slPdelqhpyskfseWKFKLFrvrslekapeesetekekkaelaasleakpeveldkesaageksvlklcllkkskenve 82
                 + P + +   sk s++K   F v+  +k+p+++ t++++++++  s+++ +++++d++  + ++       lk+++e v+
   EFC39631.1  3 NTPPNNTTSSSKMSNFKLFSFLVKKRKKTPTNNSTSTDQQTDSPRSSNSDTDMMIDTSPRTMTS------SLKHTPEYVD 76
                 5666777788999*99999999****************98888888888888887754442222......3333444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (128 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1194  (0.066596); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.43u 0.31s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 864.87
//
Query:       EFC39632.1  [L=1023]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.7e-14   53.7   0.5    4.4e-14   52.4   0.5    1.6  1  Rad51     Rad51
    8.4e-08   31.8   0.3    1.8e-07   30.8   0.3    1.5  1  ATPase    KaiC
    9.8e-05   22.0   0.0    0.00017   21.2   0.0    1.3  1  AAA_25    AAA domain
     0.0082   15.6   0.0        1.5    8.3   0.0    2.4  2  RecA      recA bacterial DNA recombination protein
  ------ inclusion threshold ------
       0.19   11.3   0.2        2.5    7.6   0.2    2.2  1  CobU      Cobinamide kinase / cobinamide phosphate guanyltran
        8.9    6.9  33.5        1.4    9.4   0.2    8.7  8  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> Rad51  Rad51
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.4   0.5   1.5e-17   4.4e-14      26     251 ..     796    1014 ..     793    1018 .. 0.72

  Alignments for each domain:
  == domain 1  score: 52.4 bits;  conditional E-value: 1.5e-17
                  HHHHHTSSEESSSEEEEEESTTSSHHHHHHHHHHHTTS-TTTS--SSEEEEEESSS---G..GGGHHHH.HHT.T--HHHHGGGEEEEE--ST.... CS
       Rad51   26 lDelLgGGietgsiteifGefrsGktqlchtlcvtvqlplelgGgegkavyidtegtfrp..erlveia.ery.kldkeevlenvayaRayti.... 114 
                  +++l +GGi+   itei+G   sGk+ +c +      ++ ++      +v  dte       +r+  +  +r  ++ ++e+ e++       +    
  EFC39632.1  796 FNTLFHGGIPLNMITEIVGATTSGKSEFCLSAVSDLLMEFDKF----GCVIFDTEVKQANifQRIYFMMkNRNpDMSESEIEERILKKCTIIHvass 888 
                  78899************************76544444444444....47888999654432267765544676788877776666554433223111 PP

                  THHHHHHHHTHHHHHHS-EEEEEEETTTGGGCH-------.THHHHHHHHHHHHHHHHHHHHH--EEEEEEE-------.------------HHHHH CS
       Rad51  115 ehqeellqqaaallaedkfallivDsvtalyRtdfsgrge.lakRqqklgkllrtLrkladefevavvitnqvvaqvdgqaalfsadpkkPigGlvl 210 
                   +  + l+++ + + e++++l+++Ds+++l   +f+g++    +R   l   ++ L++l ++f+v v++tn  +++ ++             +G  +
  EFC39632.1  889 KELIDSLDNLEEFIFEKNIKLIVIDSLATLSTKEFQGKEGgAFERASILQTEATLLKQLNEKFKVGVLVTNSLSSSDEA------------QLGINW 973 
                  555555668889999**********************8651669****************************9988666............456667 PP

                  HHH-SEEEEEEE-STTEEEEEEES-SSS-S-EEEEEEETTE CS
       Rad51  211 ahasttRlalrkgkgeeRivkvvdsPnlpeleavfaigeeG 251 
                   h +  Rl++ k  +++ i+ +v+s    + ++ + + + G
  EFC39632.1  974 YHFVNHRLKIYKIGESKAIINIVKSSIANNVNIHVNMADLG 1014
                  77777777777777777777777776666666666665555 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8   0.3   5.9e-11   1.8e-07       4     139 ..     792     926 ..     791     987 .. 0.68

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 5.9e-11
      ATPase   4 gIeglDeilkgGipegrvvlitGepGtGKtifalqFlikgaekygepgvfv.tveepa....edlrenakslGwdlekleeegklaiidasesaeesae 97 
                 +I+ + ++++gGip + ++ i+G + +GK+ f+l  +   ++++++ g  +  +e ++    + ++  +k+   d+ + e e++  i+   +     ++
  EFC39632.1 792 YIPSFNTLFHGGIPLNMITEIVGATTSGKSEFCLSAVSDLLMEFDKFGCVIfDTEVKQanifQRIYFMMKNRNPDMSESEIEER--ILKKCTI----IH 884
                 799*****************************************9976555267888844444444445555555555554432..2333332....33 PP

      ATPase  98 ekdkedleelieelaeaikeikakrvviDsitglayeekeav 139
                   ++++l   +++l+e i e+++k +viDs+++l+++e + +
  EFC39632.1 885 VASSKELIDSLDNLEEFIFEKNIKLIVIDSLATLSTKEFQGK 926
                 3345556666689*********************66655443 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.2   0.0   5.8e-08   0.00017      19     155 ..     793     919 ..     789     938 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.2 bits;  conditional E-value: 5.8e-08
      AAA_25  19 ppprrwlvkgllpagelallaGapgtGKttlaldlalavatGkpwlgpvapeqgkVlyvsaEdsedelrrRlravgealrddarllvldlagv.eslpL 116
                 +p+ + l++g +p++ ++ ++Ga+ +GK+ ++l+ + +++   ++       +  +++ ++E +++++ +R++ +++++++d  +  +   +  ++ ++
  EFC39632.1 793 IPSFNTLFHGGIPLNMITEIVGATTSGKSEFCLSAVSDLLM--EF------DKFGCVIFDTEVKQANIFQRIYFMMKNRNPDMSESEIEE-RIlKKCTI 882
                 6778899********************************94..22......3458***********************955544444442.33355566 PP

      AAA_25 117 fakdrggtlltadvdaleaaieevegvrlvviDplsral 155
                 ++  +  +l+++ +d+le+ i e ++++l+viD+l+ + 
  EFC39632.1 883 IHVASSKELIDS-LDNLEEFIFE-KNIKLIVIDSLATLS 919
                 666667777776.69********.99*********9765 PP

>> RecA  recA bacterial DNA recombination protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0   0.00049       1.5      46      77 ..     800     831 ..     793     853 .. 0.84
   2 !    4.8   0.0    0.0056        17     119     152 ..     894     926 ..     882    1008 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00049
                 SSSSEETTSEEEEEESTTSSHHHHHHHHHHHH CS
        RecA  46 GiGGlpkGriieiyGpessGkttlalhaiaea 77 
                   GG+p   i+ei G+ +sGk+ ++l+a+++ 
  EFC39632.1 800 FHGGIPLNMITEIVGATTSGKSEFCLSAVSDL 831
                 569************************99875 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.0056
                 HHHHHHHHHTTT--SEEEEE-TTT---STT---- CS
        RecA 119 aleiadalvrsgaidlivvdsvaalvpkaeieGe 152
                 +l+ ++ ++    i liv+ds+a+l  k e +G+
  EFC39632.1 894 SLDNLEEFIFEKNIKLIVIDSLATLSTK-EFQGK 926
                 688889999999************9876.55554 PP

>> CobU  Cobinamide kinase / cobinamide phosphate guanyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.2   0.00084       2.5      55     126 ..     890     961 ..     810     969 .. 0.75

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00084
        CobU  55 etveepldlaealkeeekkevvLvDcltlwltnllleeeaek.veekleeeveellealkelkatvvlVsnEv 126
                 e++++  +l+e + e++  + +++D+l+++ t+ ++ +e  +  ++++ ++ ++ll++l+e+ +  vlV+n +
  EFC39632.1 890 ELIDSLDNLEEFIFEKNI-KLIVIDSLATLSTKEFQGKEGGAfERASILQTEATLLKQLNEKFKVGVLVTNSL 961
                 455666677777766665.899999999999999998776665667999999999999999999999999975 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   1.4     0.022        65       1      30 [.     138     171 ..     135     178 .. 0.66
   2 ?    3.9   0.2     0.026        79      19      38 ..     276     295 ..     264     308 .. 0.79
   3 ?    1.9   0.1      0.11   3.3e+02       1      28 [.     328     354 ..     328     365 .. 0.81
   4 ?    9.4   0.2   0.00048       1.4      15      39 ..     392     416 ..     383     442 .. 0.85
   5 ?    0.5   0.0      0.31   9.4e+02       5      31 ..     583     608 ..     581     614 .. 0.77
   6 ?    2.5   2.0     0.074   2.2e+02      19      39 ..     622     639 ..     616     685 .. 0.81
   7 ?   -1.9   0.0       1.8   5.3e+03      22      33 ..     698     709 ..     688     718 .. 0.66
   8 ?   -1.8   0.1       1.6   4.9e+03      21      36 ..     894     909 ..     886     918 .. 0.62

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.022
                 SS--EEE--...SS---E-S-..HHH-TT--EEE- CS
       LRR_4   1 pnLevLdLs...nNqltdipl..leklpnLkeLdL 30 
                 pn e+L+L+   +N+l  +++  +    nL++L++
  EFC39632.1 138 PNIEELYLNisySNNLAIFQPnqFL-WNNLQHLTV 171
                 6777777777566999955553422.344888876 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.026
                 HHH-TT--EEE-.-S----- CS
       LRR_4  19 leklpnLkeLdLsgNnlitd 38 
                 l+++ nL++L+++g   i++
  EFC39632.1 276 LSSFSNLRQLYINGSKSIEK 295
                 55799*******88755555 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.11
                 SS--EEE--SS---E-S-HHH-TT--EE CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeL 28 
                 p+L++L++s+++l  + +  kl  L++L
  EFC39632.1 328 PKLKNLCISGCKLI-LHSSTKLARLRYL 354
                 79999999999988.6667778888887 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.00048
                 E-S-.HHH-TT--EEE-.-S-----G CS
       LRR_4  15 dipl.leklpnLkeLdLsgNnlitdl 39 
                 +i+l ++++++L++L+Ls+ n++ d+
  EFC39632.1 392 SISLaFNNMKHLRQLYLSDINKV-DV 416
                 56667889*********997777.55 PP

  == domain 5  score: 0.5 bits;  conditional E-value: 0.31
                 EEE--SS---E-S-HHH-TT--EEE-. CS
       LRR_4   5 vLdLsnNqltdiplleklpnLkeLdLs 31 
                 +L++  ++ t + +++++++ +++ Ls
  EFC39632.1 583 ELSID-TNCTVVKPPQNMDSITHFKLS 608
                 55555.56788889999*****99996 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.074
                 HHH-TT--EEE-.-S-----G CS
       LRR_4  19 leklpnLkeLdLsgNnlitdl 39 
                 ++kl nL++L+L g+   tdl
  EFC39632.1 622 IQKLSNLTSLSLRGF---TDL 639
                 456888888888554...344 PP

  == domain 7  score: -1.9 bits;  conditional E-value: 1.8
                 -TT--EEE-.-S CS
       LRR_4  22 lpnLkeLdLsgN 33 
                 +   keL+Ls  
  EFC39632.1 698 IYCIKELNLSAK 709
                 556788888554 PP

  == domain 8  score: -1.8 bits;  conditional E-value: 1.6
                 H-TT--EEE-.-S--- CS
       LRR_4  21 klpnLkeLdLsgNnli 36 
                 +l+nL+e+    N ++
  EFC39632.1 894 SLDNLEEFIFEKNIKL 909
                 4778887744656554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1023 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       700  (0.0390429); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.48
# Mc/sec: 6409.90
//
Query:       EFC39633.1  [L=616]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    6.5e-60  202.9   0.0    1.1e-59  202.1   0.0    1.4  2  AMP-binding    AMP-binding enzyme
    2.7e-05   25.0   0.2    5.8e-05   24.0   0.2    1.6  1  AMP-binding_C  AMP-binding enzyme C-terminal domain
  ------ inclusion threshold ------
      0.015   15.3   0.0      0.035   14.2   0.0    1.6  1  Peptidase_C42  Beet yellows virus-type papain-like endopeptid


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  202.1   0.0   1.9e-63   1.1e-59       4     421 ..      41     502 ..      38     504 .. 0.80
   2 ?   -3.2   0.0      0.39   2.3e+03      16      38 ..     547     571 ..     541     571 .. 0.81

  Alignments for each domain:
  == domain 1  score: 202.1 bits;  conditional E-value: 1.9e-63
                  HHHHSTTSEEEEECCSTEEEEHHHHHHHHHHHHHHHHHTTSSTT-EEEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHHTESEEE.. CS
  AMP-binding   4 qaaktpdkvalvdsgegqtlTYreldervnrlAagLrslGvkkgdrVaillpnspewvvallailkaGavvvplnptltaeelayiledseakvli.. 99 
                  +a++++  +al   ++g  ++Y+ l++ ++++Aa L++ G+kkgd Va  lp + e++ +l+a++++G+v++pl+ +l+++e+a ++++ ++k+ +  
   EFC39633.1  41 HANTKKSNPALCEFNTGDEISYATLRQSSTAFAAKLLECGLKKGDIVATSLPFMKEHIYLLFACMRLGVVIAPLDLRLKEHEIAKCFDAIRPKMYFfl 138
                  6788889999966567999******************99*********************************************************88 PP

                  .....ETCTCCC.HHHHHHHHSCC-EECEEEEESCCS-HCCHCCCHCCCCSCTTS............................-TSCCCS-BTTSEEE CS
  AMP-binding 100 .....atvdsel.leklleaaakleavklvivldadellkeeelkeeeeseekae............................kpeeeeelkpddlay 163
                       a  d +  +++l ++ +k  ++ + ++++  +++ke++l ++                                        e++++p+d+a+
   EFC39633.1 139 gqtpvA--DFRPmVSNLMKNYKK-TETGTGTITHWVQFQKEKDLVIDG------AigildfvanvkslfifdylkswvgggvaY--HESQVSPNDPAI 225
                  754321..333334444444443.333444455555555555555555......0334557778899999999********742..44589******* PP

                  EEEE--SSSS-EEEEEEHHHHHHHHHHHH...HHHCSCCTTT-EEEESS-TTSCHHHHHHHHHHHHTT-EEEE-TTCGCCHHHHHHHHHHHHT-SEEE CS
  AMP-binding 164 iiYTSGTTGkPKGVmlshrnlvanvaslk...letrfklkeddvvlsilplahifglilelllallsGatvvllpkdaaldpklllelieklkvtvia 258
                  ii+T G+TG+PK++ lsh+n++ +   lk   ++  +  +e+ v+l+ lp +h+  ++   ++++++G+++v+l+ ++a +    l++iek+kv+++ 
   EFC39633.1 226 IIFTTGSTGNPKAAKLSHANIIIQNIGLKrafFD-PWAKDETVVMLCNLPPSHVGCITEQFFTTIYAGGSCVILHIFDAEK---SLQAIEKYKVNCLG 319
                  ************************9998865322.2333456777999***************************999933...37************ PP

                  EEHHHHHHHHHCCCHHCHHHHCCGTT-SEEEEESS-EBHHHHHHHHHHHTCEEEEEEEEGGGSSECEE....CHCTTTCTSTTS-B............ CS
  AMP-binding 259 gvPrvleallesgalkaakkakdlsslrlvllggeplspellrffralfgeevlegYGlTEttgvvtv....lpleedkkklgsvG............ 340
                   +P++++   + ++ +    ++dlssl+l++ gg+++  + l++++   +  +  g GlTEt+g+vt+    +   +  +   s+G            
   EFC39633.1 320 QIPALFQLQWRLPNYS----KYDLSSLKLAIYGGQAVTTQFLEKMQTMAPL-ICSGLGLTETAGFVTYsqlgV---GVSEIMASIGydsplcpisvre 409
                  *******999975544....67*************************9886.**************9986541...3334556677666665555555 PP

                  EE-TTEEEEEE-TTTSCBEETTSEEEEEEEETTS-SEBTT-...HHHHHHHEEE..............TCC.EEEEEEEEEEETTSEEEEEEECCCEE CS
  AMP-binding 341 kplpgvevkivDeetgepvpdgeeGellvrgpgvmkgYlkk...peataeafds..............egr.wlrTGDlgrldedGyleivgRkkdli 420
                  +p+    v+i+  e     +  e+Ge+++ gp+++ gY++    pe+ ae++ +              +++  l TGD+g +d +  l++  R k +i
   EFC39633.1 410 PPVLVDGVYIAGAE----KKASEVGEVCFTGPQIFVGYHGAdenPEL-AETMRQtivpltiekkeskdPNDfILYTGDVGSYD-NLGLHFASRRKFVI 501
                  77777778887776....457899***************95233444.444444567789999999754788***********.7779*******999 PP

                  E CS
  AMP-binding 421 k 421
                  k
   EFC39633.1 502 K 502
                  8 PP

  == domain 2  score: -3.2 bits;  conditional E-value: 0.39
                  E..CCSTEEEEHHHHHHHHHHHHHH CS
  AMP-binding  16 d..sgegqtlTYreldervnrlAag 38 
                     ++e++++T +++ +++n++Aa+
   EFC39633.1 547 ElkDKEDKSITVSDVMKACNEMAAY 571
                  34467899**************986 PP

>> AMP-binding_C  AMP-binding enzyme C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.0   0.2   9.7e-09   5.8e-05      10      76 .]     523     591 ..     512     591 .. 0.82

  Alignments for each domain:
  == domain 1  score: 24.0 bits;  conditional E-value: 9.7e-09
                    TTEEEEEEE-----TTS---EEEEEE------..HHHHHHHHHHHHT-TTTS-SEEEE-.S---B-TTS- CS
  AMP-binding_C  10 paVaeaaVvGvpdevkGealvafVvlkdgsea..leeeLkahvrkelgpyavpkkvvfv.delpktrsGK 76 
                    +++a +++vGv++e+  e +v+++ lkd +++  +  ++++ +  e+++y++p++vvf+ +++p++r  K
     EFC39633.1 523 EKIARVGAVGVDHEIFSEGIVVLIELKDKEDKsiTVSDVMKAC-NEMAAYKRPSHVVFLtSDMPLNRVAK 591
                    4699***********99*********96642246889999988.799**********88579****9887 PP

>> Peptidase_C42  Beet yellows virus-type papain-like endopeptidase C42
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   5.8e-06     0.035       3      67 ..     290     356 ..     288     363 .. 0.88

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 5.8e-06
  Peptidase_C42   3 lkdGlCYlaHvaevcafllrvfreadlalGafPtvaklkarl..vreyGkealklglrGaytsrsvf 67 
                    +  G C + H++++  +l+ + + +   lG  P  ++l+ rl   ++y  ++lkl+++G ++ +  f
     EFC39633.1 290 YAGGSCVILHIFDAEKSLQAIEKYKVNCLGQIPALFQLQWRLpnYSKYDLSSLKLAIYGGQAVTTQF 356
                    6789**********99999988888889*************944579************98877655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (616 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       425  (0.0237046); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.25s 00:00:00.73 Elapsed: 00:00:00.41
# Mc/sec: 4513.88
//
Query:       EFC39634.1  [L=794]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.7e-79  265.0   0.4    1.1e-78  264.5   0.4    1.2  1  PhoPQ_related  PhoPQ-activated pathogenicity-related protein
    9.8e-35  120.4   5.7    2.2e-34  119.2   5.7    1.6  1  Trypsin        Trypsin
     0.0004   21.3   0.2     0.0011   19.8   0.2    1.8  1  Trypsin_2      Trypsin-like peptidase domain


Domain annotation for each model (and alignments):
>> PhoPQ_related  PhoPQ-activated pathogenicity-related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  264.5   0.4   1.8e-82   1.1e-78       1     366 []      34     401 ..      34     401 .. 0.95

  Alignments for each domain:
  == domain 1  score: 264.5 bits;  conditional E-value: 1.8e-82
  PhoPQ_related   1 lkdyvekedeelkyeltetkelegvtiyileltSQkWskeklvd.pslwkHkltivvPke.kkleetalllisggsnenvkkkskesesetlaeia 94 
                    l++yv+++++  +y+l +t++++++t+y+l++t  +  +  +v  +s+w   +t+ vP + +k++++a ++ +ggs    ++ s++  +++++  +
     EFC39634.1  34 LANYVASPESVTSYTLLSTVQTTVATVYVLNVTTLSFLTPAEVGvRSTWFNYVTVSVPISlDKTKSQATVYFTGGS----NTGSVPGVDAIITPYS 125
                    789*********************************998877752679***********98999************....6667778888999999 PP

  PhoPQ_related  95 retkavvaelsdvPnqpltfeddgk..arkEDdlvAytwrkfleeekdetlplllpmtkaavraMdlvqeflkel.klkiekFvvsGaSKRGWttw 187
                      tk+v ++++d+Pnqp+t++ d++  +r+ED+++A+ w++f++++++ + + +lpm+ka   a+d+v +f+k++ +++i ++ v GaSKRGW++ 
     EFC39634.1 126 YATKSVGVTVYDIPNQPITYASDPTqaSRSEDAIIAFGWKRFINDTANVNYVTQLPMVKASKIALDVVTKFVKSTvNYEIATWNVIGASKRGWSSI 221
                    9*********************98744799********************************************99******************** PP

  PhoPQ_related 188 ltaivDkrvkaivPvvidilnlekqlkhqlkaYGewslaledYvaegidellktpefkkLlkivDplsYlerltipkyiinasgDdffvpdstkfy 283
                    l a vD+rv+++vP vi+++ +++++++++++   w+ a+ dY+a+g+++ + t  f+kL+kivDp++Y +  +i ky +++ gD+ff p+  +  
     EFC39634.1 222 LLAGVDSRVTSLVPAVIPVWHTKEVFERTYNNICYWPPAMADYIAAGVTNDMFTTGFEKLTKIVDPVNYPRLDQISKYQVLSLGDEFFSPELNDLG 317
                    *********************************************************************6555*********************** PP

  PhoPQ_related 284 fekLkgekalrivPnssHglsnkevveslvafvklvaagkelPeleweieesegtiklkvkssea.pekvklwtatnesarDfR 366
                    +++++g+k++r++Pn++H+l  ++v++ l ++  + ++g ++P+++++ +  ++ + +kvk ++  p++v+lw+atn++ r fR
     EFC39634.1 318 YDSIEGDKYVRYIPNTGHSLAGSDVFQVLLSYQVARLSGVTMPRFTFSHRFVDEGVIVKVKIQNNrPSRVVLWSATNPNGREFR 401
                    ********************************9999***********9999998999999977666*****************9 PP

>> Trypsin  Trypsin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  119.2   5.7   3.7e-38   2.2e-34       6     221 .]     476     732 ..     472     732 .. 0.89

  Alignments for each domain:
  == domain 1  score: 119.2 bits;  conditional E-value: 3.7e-38
                 ETTTTSSTTEEEEEETTC.....EEEEEEEEEETTEEEEEGGGTTT.......GGGEEEEESESBTTSCTTT......EEEEEEEEEEEETTEBTTTTT CS
     Trypsin   6 eaqkgsfpwqvslsvksg.....khlCgGslisenwvlTAaHCvsn.......asdvkvvlgehnlkksegk......eqklkvekvivhpnynpstld 86 
                 +a++++fp+ vs++++ +     +h+CgGs+i ++++lTAaHC  +       +s++++v g+++l++  +k       q+++v+ ++ h++y+ +++ 
  EFC39634.1 476 QASPQEFPFLVSIQYQDSssstpQHICGGSVIASKYILTAAHCNFEdsgavtnPSKLTIVYGTNSLSSCPSKvgtysaCQRVQVKSITNHEKYDGNNVV 574
                 78999**********9999************************777799999999999988887777655555556668******************** PP

                 TTEEEEEESSSSTSBSSBHCCBBCSTTHTTSTTTEEEEEESSBSSTSS..BSSBEEEEEEEEEEHHHHHHH.TTTTSTTTEEEEESTTSSSBCTTTTTT CS
     Trypsin  87 nDiallklkepvklgdtvrpiclpaassslpvgttclvsGwgrtkekg..ksdtlqevevpvvsretcksa.ykgkvtenmlcagakeggkdacqGDSG 182
                 nD+a+ +l+++++l  t + + +p +++  +vgt  +++Gwg t+++    s+ ++++  p+v+++ c+s  ++   ++ ++cag+  +g dac GDSG
  EFC39634.1 575 NDVAIYELASDISLP-TANIAMIPMTNA--AVGTPHYIIGWGLTNDNVgtASNYMMKGLAPLVDDKYCNSLgLDMSQSKGQICAGS-GNGIDACSGDSG 669
                 ***********4443.333333444455..9************888888*********************88666689********.578********* PP

                 SEEEETTT....................EEEEEEEEE.SSSSCTTS...EEEEEEGGGGHHHH CS
     Trypsin 183 GPlvcsdg....................elvGivswg.kgcakgnr...pgvytkvssyldwi 221
                 G l ++ +                     + G+vs+g +gc+        gvyt v+++++wi
  EFC39634.1 670 GGLAMQVQinsgssnssnttsgattklwVVSGLVSYGpEGCGVSSSysnRGVYTSVAYFKSWI 732
                 ******************************************99877779************9 PP

>> Trypsin_2  Trypsin-like peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.2   1.9e-07    0.0011       3     140 ..     504     672 ..     502     685 .. 0.62

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 1.9e-07
   Trypsin_2   3 GflvgsdglilTnaHvvdsadgaav..............kaikkkveeagadgrevpakvvaadp......elDlAllkvssderaglpplplgp..se 79 
                 G +++s + ilT+aH+  +++ga+                +  +kv    a  r++  ++   +         D+A++++   ++ +lp++ ++    +
  EFC39634.1 504 GSVIASKY-ILTAAHCNFEDSGAVTnpskltivygtnslSSCPSKVGTYSACQRVQVKSITNHEKydgnnvVNDVAIYEL--ASDISLPTANIAMipMT 599
                 67899999.********77777777566666665555554444444444445555444444444477764444*******..55555555554443333 PP

   Trypsin_2  80 alkggepvyvvGyplggeksgsvssGivsgvve..............sesaasgegesflqtdaatspGsSGGpl 140
                 ++++g+p y++G +l +++ g++s+ ++ g+ +              s+s+ ++   s    da    G SGG l
  EFC39634.1 600 NAAVGTPHYIIGWGLTNDNVGTASNYMMKGLAPlvddkycnslgldmSQSKGQICAGSGNGIDACS--GDSGGGL 672
                 344566*******99999988777777777777776666665544443333333333333555555..6666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (794 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       600  (0.0334653); expected 358.6 (0.02)
Passed bias filter:                      363  (0.0202465); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.29s 00:00:01.02 Elapsed: 00:00:00.50
# Mc/sec: 4743.09
//
Query:       EFC39635.1  [L=340]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.012   15.9   0.0       0.95    9.8   0.0    2.4  2  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
       0.65   10.1   2.1        1.1    9.4   0.1    2.5  3  NHL          NHL repeat


Domain annotation for each model (and alignments):
>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.0    0.0092        82      49      74 ..     192     218 ..     187     223 .. 0.87
   2 ?    9.8   0.0   0.00011      0.95       1      89 [.     234     321 ..     234     324 .. 0.84

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0092
  ANAPC4_WD40  49 dgklLavaysdg.evrlldaesgkvvh 74 
                   g+l++va  d+ +++l+d+ +g++++
   EFC39635.1 192 RGNLIVVADTDNkRLKLYDSLDGNLLK 218
                  699*****9999789******999886 PP

  == domain 2  score: 9.8 bits;  conditional E-value: 0.00011
  ANAPC4_WD40   1 lswcptmDLiAlatedgellvfRlngqrvwtleedkedsevrsLaWkpdgklLavaysdg.evrlldaesgkvvhslsvksekavtclgW 89 
                  + ++ + DL+ +++ +++   + l+ +  +++++ ++ +++ +L+++p+ +   +  s++  + +++ es kv ++++ + +  v+++++
   EFC39635.1 234 MIYSKELDLFLIVSREKSFFKCKLSHNLQFEASQLSTTQSIWCLCYEPSSRKVLFPNSNSsLICVMNLESMKVEKEYKGEGT--VSSISF 321
                  689*********************************************9876666666552678899999999888876655..777776 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1      0.51   4.5e+03       7      16 ..      80      89 ..      79      89 .. 0.82
   2 ?   -3.7   0.0       1.8   1.6e+04      21      27 ..     154     160 ..     154     160 .. 0.82
   3 ?    9.4   0.1   0.00012       1.1      11      26 ..     192     207 ..     189     209 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.51
                EEEETTTEEE CS
         NHL  7 vavdsnGdiy 16
                v ++++G+i+
  EFC39635.1 80 VYLNDDGNII 89
                67889**996 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 1.8
                 CCTEEEE CS
         NHL  21 enhrvqv 27 
                 e+++++v
  EFC39635.1 154 ETNCIWV 160
                 6799998 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00012
                 TTTEEEEEECCCTEEE CS
         NHL  11 snGdiyVaDsenhrvq 26 
                  ++ i+VaD+ n r++
  EFC39635.1 192 RGNLIVVADTDNKRLK 207
                 6899*********985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (340 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       376  (0.0209716); expected 358.6 (0.02)
Passed bias filter:                      268  (0.0149478); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.48u 0.24s 00:00:00.72 Elapsed: 00:00:00.43
# Mc/sec: 2366.16
//
Query:       EFC39636.1  [L=285]
Description: FabG domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.9e-16   58.1   0.0    3.1e-14   52.9   0.2    2.3  2  adh_short       short chain dehydrogenase
    1.2e-11   44.7   0.0    1.9e-11   44.0   0.0    1.2  1  adh_short_C2    Enoyl-(Acyl carrier protein) reductase
    2.3e-06   27.7   0.1      4e-06   26.9   0.1    1.3  1  KR              KR domain
      0.003   16.8   0.1      0.004   16.3   0.1    1.2  1  PAE             Pectinacetylesterase
  ------ inclusion threshold ------
       0.11   12.3   0.0       0.21   11.4   0.0    1.6  1  NAD_binding_10  NAD(P)H-binding


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.9   0.2   8.6e-18   3.1e-14       1      99 [.       4     104 ..       4     145 .. 0.82
   2 ?    2.4   0.0     0.026        92     160     190 ..     178     208 ..     168     212 .. 0.86

  Alignments for each domain:
  == domain 1  score: 52.9 bits;  conditional E-value: 8.6e-18
                 SEEEEESTTSHHHHHHHHHHHHTT-EEEEEESCHHHHHHHHHHHHHT..TSEEEEEE-TTTSHHHHHHHHHHHHHHHSSESEEEE---SS--SSGGGCS CS
   adh_short   1 kvvlvtGassGIGraiakelakeGakvvvvdrseekleevakelkee..gakalaiqvDvtdreevealvekavkklgkldvLvnNAGitgsgpfsels 97 
                 k +l +G++sGIGra+a +la++ ++v +++rse++ +e+++e++++  + k+ +i+vD t ++++e++ e+ +k++++ld  v   Gi+++g+  e++
  EFC39636.1   4 KQALCVGGTSGIGRALAIKLASQKINVSIMGRSEQAGKEIIEEMQKLnpQGKFEMISVDATLMKDIERVCEEYKKNHDRLDYCVLTQGIANMGARTETK 102
                 57899******************************************99999*************************************8888777765 PP

                 HH CS
   adh_short  98 ee 99 
                 e 
  EFC39636.1 103 EG 104
                 53 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.026
                 HHHHHHHHGGGTEEEEEEEESSBSSHHHHHH CS
   adh_short 160 trslakelaptgirvnavaPGlvdTdmakel 190
                 ++sl+++  +++i  +  +PG+++T+  +el
  EFC39636.1 178 MDSLSRDEGNENIAFMHQYPGFIATQWGREL 208
                 6789999999***************987765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   44.0   0.0   5.3e-15   1.9e-11       3     140 ..      12     151 ..      10     155 .. 0.81

  Alignments for each domain:
  == domain 1  score: 44.0 bits;  conditional E-value: 5.3e-15
                   TTSHHHHHHHHHHHTT-EEEEEESSGGH.HHHHHHHHHHTTSE.E..EE--TTSHHHHHHHHHHHHHHHSSEEEEEE-----EGCSS-GGGH-HHHH CS
  adh_short_C2   3 asgIGraiAkalaeeGaevvltdlneea.kkrveelaeelgae.v..lecDVtdeeqvealveevvekfgklDilvnnagiapklkgpfletsreef 95 
                    sgIGra+A +la++  +v ++ ++e+a k+ +ee+++  ++  +  + +D+t  +++e++ ee ++++++lD++v   gia+   g   + ++e++
    EFC39636.1  12 TSGIGRALAIKLASQKINVSIMGRSEQAgKEIIEEMQKLNPQGkFemISVDATLMKDIERVCEEYKKNHDRLDYCVLTQGIANM--GA-RTETKEGL 105
                   69**************************8887777777555334455************************************9..44.45568999 PP

                   HHHHHHHTHHHHHHHHHHHHHCTSC..CEEEEEEEGGGTSBSTTTTH CS
  adh_short_C2  96 draldvnlyslfllakaalplmkeg..gsivnlssvgaervvpnyna 140
                   +  l+   y+ +l++++++ l++++   s v + sv +  ++ +y++
    EFC39636.1 106 EFKLALHYYGRMLFIRQLQDLLRSTskNSNVKVLSVLS-AGIHSYTH 151
                   9999999*************888774545555444422.34555555 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.9   0.1   1.1e-09     4e-06       4      93 ..       7      94 ..       5     107 .. 0.86

  Alignments for each domain:
  == domain 1  score: 26.9 bits;  conditional E-value: 1.1e-09
                EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE------ CS
          KR  4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkdavealleeikaeeppikGvihaAgvlr 93
                l +GG+ g+G++la  la++ + ++ +++Rs++a ++  +++++l+ +g + e++++D +  +++e++ ee+k++++++  ++ + g+++
  EFC39636.1  7 LCVGGTSGIGRALAIKLASQ-KINVSIMGRSEQAGKEIIEEMQKLNPQG-KFEMISVDATLMKDIERVCEEYKKNHDRLDYCVLTQGIAN 94
                679***************98.56899*****877777777777777766.89***********************999998887777765 PP

>> PAE  Pectinacetylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.1   1.1e-06     0.004      97     191 ..      77     176 ..      55     194 .. 0.78

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 1.1e-06
         PAE  97 nwNrvkvrYC...dgasfsGdveevdkst....klyFrGqrilqaviedLlekglkkakkvlLsGcSAGglaailhcdklrellpkeakvkclsda.Gf 187
                 + N+ ++ YC   +g +  G + e++++      l++ G+  +   ++dLl+   k+++  +Ls  SAG + +++h+d+l   l++++++k+ +da Gf
  EFC39636.1  77 KKNHDRLDYCvltQGIANMGARTETKEGLefklALHYYGRMLFIRQLQDLLRSTSKNSNVKVLSVLSAG-IHSYTHMDDLD--LKQNYTLKNAADAsGF 172
                 55666666664444555666666443333444499*********************************7.889******97..9999*******96477 PP

         PAE 188 Flda 191
                 + d 
  EFC39636.1 173 YNDL 176
                 7665 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   5.9e-05      0.21       1      59 [.      10      74 ..      10     180 .. 0.66

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 5.9e-05
                    TTTSHHHHHHHHHHHHC-T-EEEEEETTHHHCH.......HHHCTTTCEEEE--TT-CCHHHHHHT CS
  NAD_binding_10  1 GAtGkvGrllvkellargghevtalvRnpekla.......eleaeeglevvegdvtdvedlaealk 59
                    G+t ++Gr+l+ +l++++ ++v ++ R+++  +       +l  + + e++++d+t  +d++++++
      EFC39636.1 10 GGTSGIGRALAIKLASQK-INVSIMGRSEQAGKeiieemqKLNPQGKFEMISVDATLMKDIERVCE 74
                    99***************5.*********76555111111144455688888999888888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (285 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       626  (0.0349155); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.67u 0.36s 00:00:01.03 Elapsed: 00:00:00.58
# Mc/sec: 1474.96
//
Query:       EFC39637.1  [L=298]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.04   14.3   0.2       0.04   14.3   0.2    1.9  2  DUF4379   Probable Zinc-ribbon domain
      0.062   13.5   2.0      0.062   13.5   2.0    2.3  2  CHCH      CHCH domain


Domain annotation for each model (and alignments):
>> DUF4379  Probable Zinc-ribbon domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.2   4.5e-06      0.04       5      44 ..      93     132 ..      91     140 .. 0.85
   2 ?   -3.0   0.2       1.1     1e+04      45      56 .]     235     246 ..     234     246 .. 0.59

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 4.5e-06
     DUF4379   5 keWdye.knpdlkpeevtpgskkkvwWkCakCgheWeasvs 44 
                 k W+   k  dl+p+e+    k+ + W C + g++We+ v+
  EFC39637.1  93 KSWSNReKILDLSPKEFESVGKEVANWDCLE-GETWEKFVN 132
                 6788663559*********************.*****9887 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1.1
     DUF4379  45 nrt.kgsskCpkC 56 
                 +r+ +++  C  C
  EFC39637.1 235 DRIvNRKM-CEAC 246
                 56524444.9998 PP

>> CHCH  CHCH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0         1   8.9e+03      18      29 ..      29      42 ..      25      44 .. 0.64
   2 ?   13.5   2.0   6.9e-06     0.062       6      34 ..     254     283 ..     253     284 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1
                S..TTTTHHHHHHH CS
        CHCH 18 e..fskCrkefeaf 29
                +  +s C  +f ++
  EFC39637.1 29 QntSSPCNPLFNKL 42
                33488998887655 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 6.9e-06
                 HHHHHHHHHCTS.STTTTHHHHHHHHHHHC CS
        CHCH   6 keylkClkdnsd.efskCrkefeafkeCvk 34 
                 k+ ++C+++n + ef+kC   ++a+  C++
  EFC39637.1 254 KQIQTCFEKNLNsEFDKCLLDNDAYSRCIE 283
                 899*********56**************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (298 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       810  (0.0451782); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1878.42
//
Query:       EFC39638.1  [L=712]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    5.7e-09   36.6   0.0    1.7e-08   35.1   0.0    1.8  2  NAD_binding_1   Oxidoreductase NAD-binding domain
    9.1e-09   35.4   0.0    2.4e-07   30.9   0.0    2.5  2  Putative_PNPOx  Pyridoxamine 5'-phosphate oxidase
    6.2e-06   26.5   0.1    0.00081   19.7   0.0    2.9  2  FAD_binding_6   Oxidoreductase FAD-binding domain
    6.5e-05   23.1   0.1     0.0005   20.2   0.0    2.2  2  NAD_binding_6   Ferric reductase NAD binding domain


Domain annotation for each model (and alignments):
>> NAD_binding_1  Oxidoreductase NAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0       3.9   1.8e+04      25      47 ..      76      98 ..      68     113 .. 0.62
   2 !   35.1   0.0   3.8e-12   1.7e-08       1     105 [.     578     689 ..     578     692 .. 0.88

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3.9
                   CSEEEEEEEESSGCGSTTHHHHH CS
  NAD_binding_1 25 ktkvvlvyGnrteedllyreele 47
                   ++ +  +++++++++++ ++ + 
     EFC39638.1 76 ECWCSSIWATPKQHEMYSKQSTL 98
                   45555677777777776665443 PP

  == domain 2  score: 35.1 bits;  conditional E-value: 3.8e-12
                    EEEEGGGGHHHHHHHHHHHHH.CT......TCSEEEEEEEESSGCGSTTHHHHHHHHHHCTT.EEEEEEEESSCTTTSSSEESSHHHHHHHHHHHH CS
  NAD_binding_1   1 miagGtGiaPvrsvlrailee.ak......dktkvvlvyGnrteedllyreeleelakklpg.rlkvvavvsreeagweggkgrvqdalleellsl 88 
                    +++gG Gi+P++s++r  ++  ++      d  ++ +++  +  +d+ ++ el+++++k    +l++  +  ++ + ++ +  r++ +ll el++ 
     EFC39638.1 578 FLSGGIGITPFMSMIRGTFHSiQDsildikDAPHIQWIHSEKFVNDIPFKSELDQYKEKGIInQLNYCVTRMQDVSMEDVKCQRLDMKLLSELVK- 672
                    689*****************96669****9999***********************766554677777777777778888999************. PP

                    SSTTEEEEEECSHHHHH CS
  NAD_binding_1  89 kkeethvyvCGppgMik 105
                    + ee  vyvCGp ++ +
     EFC39638.1 673 DVEERVVYVCGPTPFNE 689
                    89**********99876 PP

>> Putative_PNPOx  Pyridoxamine 5'-phosphate oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.064   2.9e+02       2      38 ..      52      89 ..      51     120 .. 0.84
   2 !   30.9   0.0   5.3e-11   2.4e-07       4      88 .]     273     364 ..     270     364 .. 0.88

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.064
                    HHHHHHHHHHSSEEEEEEEETT.SEEEEEEEEEEEETT CS
  Putative_PNPOx  2 deelreflaeskavvlATvded.GrPnvspvllkagdg 38
                    +ee+ +fl e+ +v++A+ d++ +  ++s ++  + + 
      EFC39638.1 52 PEEFHSFLMERFVVFVASFDKEtNECWCSSIWATPKQH 89
                    579999**************654889999888776655 PP

  == domain 2  score: 30.9 bits;  conditional E-value: 5.3e-11
                     HHHHHHHHSSEEEEEEEETTSEEEEEEEEEEEETTT.......TEEEEEEETTSHHHHHHHHH-EEEEEEEETTGSEEEEEEEEEEEESCHH CS
  Putative_PNPOx   4 elreflaeskavvlATvdedGrPnvspvllkagdgr.......dgivfatnadsrklrnleenprvallflddelgrgvrieGtaelvsdge 88 
                      + +f+ ++++++++Tv+++   ++s++++ +g+ r          ++ +  ++++l+n e+ + ++llf+d++ g  +++ G++++ +++e
      EFC39638.1 273 NVIKFILGADTMMISTVHPEKGADCSHRGGRPGFIRiidrdtlVWGDYVGKGMFQTLGNTENCSSAGLLFIDFDHGHILQLTGNIQVTWREE 364
                     55689999******************************9965523345679999********************************988775 PP

>> FAD_binding_6  Oxidoreductase FAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       1.1   4.8e+03      62      86 ..     161     185 ..     152     192 .. 0.78
   2 !   19.7   0.0   1.8e-07   0.00081       2      87 ..     440     541 ..     439     553 .. 0.77

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 1.1
                    EEEEEEE--TT-HHHHHHHCS-TT- CS
  FAD_binding_6  62 elellvkvypgGkmsqaLdelkigd 86 
                    +++ l+k+ ++G + ++L++ + +d
     EFC39638.1 161 HFNQLIKISKDGTIIKILKSPNEND 185
                    6777899999999999998766555 PP

  == domain 2  score: 19.7 bits;  conditional E-value: 1.8e-07
                    EEEEEEEECCTTEEEEEEEESTTTS-----TT-EEEEEECETTCCEEEEEE.BSS..............T..TECCEEEEEEE--TT-HHHHHH.H CS
  FAD_binding_6   2 lkltekeevsedtrifrfklpsekqklglpvGqhvflrlkikgeaviRsYtpiss..............e..nekGelellvkvypgGkmsqaL.d 80 
                    +kl+++++++++++ f f++ + + ++ +++Gq+   +l+ +   ++Rs+t+ s+                 ne++++e+ vk++  Gk s+ L +
     EFC39638.1 440 AKLVSVKKITDEISSFGFEILEGHRNITYLPGQYATFTLSLDH-PYMRSWTVSSAmylippskdgniesGpsNETNNFEISVKKISLGKTSSWLhQ 534
                    6899************************************777.5******877433333333333322133678899999999999999999955 PP

                    CS-TT-E CS
  FAD_binding_6  81 elkigdt 87 
                     +kig+t
     EFC39638.1 535 DAKIGET 541
                    5999976 PP

>> NAD_binding_6  Ferric reductase NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.1e-07    0.0005       4      80 ..     576     652 ..     574     670 .. 0.78
   2 ?   -0.4   0.0      0.25   1.1e+03     135     151 ..     675     691 ..     663     695 .. 0.69

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.1e-07
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxx.xxxxxx RF
  NAD_binding_6   4 vllvagGiGitpfisilkdllkkskkealktkkikliwvvressslewfkdvL.neleeeksegnieihiYl.Tseyea 80 
                    vl+++gGiGitpf+s+++ ++  ++ + l++k +  i  + +++ ++ +     +el ++k++g i+  +Y+ T+++++
     EFC39638.1 576 VLFLSGGIGITPFMSMIRGTFHSIQDSILDIKDAPHIQWIHSEKFVNDIP--FkSELDQYKEKGIINQLNYCvTRMQDV 652
                    99***********************9999999998887777777777654..239999999997777666653777776 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.25
                    xxxxxxxxxxxxxxxxx RF
  NAD_binding_6 135 ssvgvfvCGppklvkev 151
                    ++  v+vCGp+ +++ +
     EFC39638.1 675 EERVVYVCGPTPFNESL 691
                    444699****9998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (712 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       424  (0.0236488); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.68u 0.30s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 4052.54
//
Query:       EFC39639.1  [L=406]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-46  158.9   0.1    2.1e-46  158.3   0.1    1.2  1  ThiF             ThiF family
  ------ inclusion threshold ------
      0.021   15.2   0.0       0.12   12.8   0.0    2.2  2  NAD_binding_7    Putative NAD(P)-binding
      0.044   13.9   0.1       0.11   12.7   0.1    1.7  1  NAD_binding_2    NAD binding domain of 6-phosphogluconate deh
       0.17   11.2   0.6       0.45    9.9   0.0    1.9  2  2-Hacid_dh_C     D-isomer specific 2-hydroxyacid dehydrogenas
        1.2    9.3   4.3       0.54   10.4   1.1    2.1  2  ASL_C            Adenylosuccinate lyase C-terminal
        1.5    9.0   5.2         24    5.2   2.2    2.9  2  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
        5.4    7.2   8.3         16    5.7   8.3    1.8  1  bZIP_2           Basic region leucine zipper
        8.5    5.9   8.7       0.15   11.6   0.9    2.2  3  UDPG_MGDP_dh_N   UDP-glucose/GDP-mannose dehydrogenase family
        9.2    5.6  16.1          2    7.8   5.2    2.9  3  GBP_C            Guanylate-binding protein, C-terminal domain


Domain annotation for each model (and alignments):
>> ThiF  ThiF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.3   0.1     1e-49   2.1e-46       1     241 [.      49     298 ..      49     304 .. 0.86

  Alignments for each domain:
  == domain 1  score: 158.3 bits;  conditional E-value: 1e-49
                 THHHHHH..HHH.HHHHHHHTSEEEEE--SHHHHHHHHHHHHHTTTEEEEEESSB--GGGGGTBTTS-GGGTTSBHHHHHHHHHHHT-TTSEEEEEES- CS
                 xxxxxxx..xxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF   1 ysrqlal..lge.dgqekLrdskvllvGaGglGsellknLalsGvgkltlvDnDkielsNlnRqflfreediGkpKaevaaealqeinpdveveavter 96 
                 ysr +al  +g  +++ek+r+ +v++vG+Gg+G  ++++L ++G+gkl l+D+D ++l N+nR f  +++++G+ K+++ +e l++inpdv  e+   +
  EFC39639.1  49 YSRLMALssMGIvKNYEKIREFTVAVVGLGGVGAVVCEMLTRCGIGKLILFDFDIVSLANMNRLFF-TPDQVGMTKVDASKETLSKINPDVVFETCSYN 146
                 67777778888889**************************************************98.******************************** PP

                 CCG.CCS-HHHHTT-...........SEEEEESSSHHHHHHHHHHHHHHT-EEEEE..EEETTEEEEEEEEECCS-ECTSS-T....GGS.EECCCCEE CS
                 xxx.xxxxxxxxxxx...........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxx....xxxxxxxxxxxx RF
        ThiF  97 itd.etvleellesv...........DlVvdalDniearrlvnracvkkgipliea..gtlgfegqvvviipgktgcyeCldp....sstedptekkvp 177
                 it+ ++  + +++++           DlV+ ++Dn+ear+++nrac +  i ++e+  +  +++g++++++pg t+cyeC +p    s  ++ +++ v+
  EFC39639.1 147 ITSlDN-FDTFMNTIntgnlltngkvDLVLSCVDNFEARVAINRACNELNIRWMESgvSEDAVSGHIQFMVPGLTACYECAPPlvvaSGVKQVKREGVC 244
                 ***999.4688555566666666677*****************************7226679*******************999954444444444444 PP

                 HHHHHHCTE-B-HHHHHHHHHHHHHHHHHHHTTBCGGGCCEEEECCTTTTEEEEECCEEEEEEC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF 178 lctsiagnipaiatttavvaglaalellkllsgkeklenslltqvdllesrfenvelerakksk 241
                 +         ++ tt+++ agl+++ +lk+l  +  +  ++l  + + + +f +++++++++++
  EFC39639.1 245 AA--------SLPTTMGITAGLLVQSVLKYLL-RFGKISYYL-GYSAINDYFPTMKVRPNPQCS 298
                 44........6********************5.443666666.677777889999998888774 PP

>> NAD_binding_7  Putative NAD(P)-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.8   0.0   6.1e-05      0.12       4      87 ..      66     196 ..      64     206 .. 0.75
   2 ?   -1.8   0.1       2.2   4.4e+03      55      82 ..     347     374 ..     309     395 .. 0.56

  Alignments for each domain:
  == domain 1  score: 12.8 bits;  conditional E-value: 6.1e-05
  NAD_binding_7   4 dlkgkkvlvvGgGevAarkvrklleag.akvtvvapevkeele.............elvklaeeelekd........................... 58 
                    ++++ +v vvG G v+a  ++ l ++g  k+++ + ++ + ++              +v++++e+l+k                            
     EFC39639.1  66 KIREFTVAVVGLGGVGAVVCEMLTRCGiGKLILFDFDIVSLANmnrlfftpdqvgmTKVDASKETLSKInpdvvfetcsynitsldnfdtfmntin 161
                    68899**********************778999888863333355666777666564455555554333555666666666677666677777777 PP

  NAD_binding_7  59 ......legadlviaatddrelneriaeaakarri 87 
                            ++dlv+ ++d+ e + +i +a+ + +i
     EFC39639.1 162 tgnlltNGKVDLVLSCVDNFEARVAINRACNELNI 196
                    777765566*********************99887 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2.2
  NAD_binding_7  55 lekdlegadlviaatddrelneriaeaa 82 
                    + +++e++d+   a  +++l++ + ++ 
     EFC39639.1 347 VADEVEDIDIHSHAHRHEDLSHGLEYQY 374
                    3444555555555555555555555444 PP

>> NAD_binding_2  NAD binding domain of 6-phosphogluconate dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.1   5.4e-05      0.11       2     150 ..      72     234 ..      71     242 .. 0.74

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 5.4e-05
                    EEEE--SHHHHHHHHHHHHTT-.EEEEE-...SSHHHHHHHHHTT....EEE-SSHHHHHHHC......SEEEE-SSSHHHHHHHHHS..HCCC-- CS
  NAD_binding_2   2 igfiGlGvMGsnmalnllkagy.kvavyn...rtkekveelvaeg....akaaesieelvasl......dvvitmvkagkavdevieg..llealk 81 
                    ++++GlG  G+  ++ l++ g+ k+++++   ++ +++++l  +     ++ ++  +e ++++      ++    +++ ++ d++++     + l 
     EFC39639.1  72 VAVVGLGGVGAVVCEMLTRCGIgKLILFDfdiVSLANMNRLFFTPdqvgMTKVDASKETLSKInpdvvfETCSYNITSLDNFDTFMNTinTGNLLT 167
                    789999999999999998888646778883333446666665543556677777778888888885555455556677777777777744447778 PP

                    TT-EEEE-S--.-HHHHHHHHHHHHHTT-EEEEEEEESHHHHHHHT-EEEEEEE-HHHHHHHHHHHHHHE CS
  NAD_binding_2  82 kgdilidgsts.spedtrelakelkekglkfldaPVSGGeegAekGtLsimvGGseeafervkpvleaig 150
                    +g++ +  s + ++e+   ++++++e ++++++ +VS   e A +G +++mv G  + +e + p+  a g
     EFC39639.1 168 NGKVDLVLSCVdNFEARVAINRACNELNIRWMESGVS---EDAVSGHIQFMVPGLTACYECAPPLVVASG 234
                    88887666666257888899999**********9998...89******************9999876655 PP

>> 2-Hacid_dh_C  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.9   0.0   0.00022      0.45      32      66 ..      65     100 ..      48     119 .. 0.87
   2 ?   -2.2   0.2       1.1   2.2e+03      65      91 ..     374     400 ..     370     401 .. 0.73

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 0.00022
                   S-GTTSEEEEES-SHHHHHHHHHHHHTT-.EEEEES CS
  2-Hacid_dh_C  32 kelsgktvGiiGlGrIGqavakrlkafgm.kviayd 66 
                   +++++ tv+++GlG +G  v ++l+  g+ k+i +d
    EFC39639.1  65 EKIREFTVAVVGLGGVGAVVCEMLTRCGIgKLILFD 100
                   679999*******************99987777666 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.1
                   ESSSHHHHHCHHHHTCEECSHHHHHHH CS
  2-Hacid_dh_C  65 ydrskkkeeeeeelgvelvsleellae 91 
                   y++++kk +e+e ++ve ++l+el+++
    EFC39639.1 374 YEHHNKKVDEKELVNVENQDLDELMKQ 400
                   555556566677778899999999986 PP

>> ASL_C  Adenylosuccinate lyase C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   1.1   0.00027      0.54      29      92 ..       5      70 ..       1      75 [. 0.83
   2 ?   -2.4   0.1       2.4   4.8e+03      78      94 ..     381     399 ..     360     403 .. 0.47

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00027
                HHHHHHCCEEE-HHHHHHHHHT-.GGGGHHHHHHHHHHTT-TTHHHHHHHHHTTS.---HHHHHHH CS
       ASL_C 29 sllkglsklevneealaedLden.wevlaEaiqtvlrregiekpYeklkeltrgk.kitkeslkef 92
                +  + +++le + + l+++L+++ ++v+ E i ++  + + ++pY +l +l       + e+++ef
  EFC39639.1  5 QSEERIKQLEEEVASLKNQLQNQqQKVIREKISVISSEVKDDNPYSRLMALSSMGiVKNYEKIREF 70
                5667899999999*******887489***********************99876635556677776 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.4
                 HHTTS..---HHHHHHHHH CS
       ASL_C  78 ltrgk..kitkeslkefie 94 
                 +  ++  ++++++l+e+++
  EFC39639.1 381 VDEKElvNVENQDLDELMK 399
                 2222233444455555544 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.1       4.4   8.7e+03     119     124 ..      21      26 ..       5      54 .. 0.53
   2 ?    5.2   2.2     0.012        24       1      39 [.      72     108 ..      72     209 .. 0.66

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.4
                      HHHHHH CS
  Sacchrp_dh_NADP 119 kekake 124
                      k + ++
       EFC39639.1  21 KNQLQN 26 
                      333332 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.012
                      EEEE--SHHHHHHHHHHHCTCCT-GEEEEEESSHHHHHH CS
  Sacchrp_dh_NADP   1 vliiGaGsvGqavaellarhfdvdaeitvadrskeklea 39 
                      v ++G G+vG +v e+l r +    ++++ d++  +l++
       EFC39639.1  72 VAVVGLGGVGAVVCEMLTRCGIG--KLILFDFDIVSLAN 108
                      56888888888888888887633..55555555555444 PP

>> bZIP_2  Basic region leucine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   8.3     0.008        16      26      53 ..       2      29 ..       1      30 [. 0.89

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.008
                HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
      bZIP_2 26 keeeleervkeLeeeNaqLrqkveqLek 53
                 +++ eer+k+Leee a L++++++ ++
  EFC39639.1  2 SQQQSEERIKQLEEEVASLKNQLQNQQQ 29
                6899*****************9998765 PP

>> UDPG_MGDP_dh_N  UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.1       3.7   7.4e+03     101     113 ..      14      26 ..       4      47 .. 0.47
   2 ?   11.6   0.9   7.8e-05      0.15       2      41 ..      71     111 ..      70     174 .. 0.87
   3 ?   -3.5   0.1       3.2   6.5e+03      43      58 ..     386     401 ..     378     404 .. 0.72

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 3.7
                     HHHHHHHHHHHHC CS
  UDPG_MGDP_dh_N 101 esaarsiaealkk 113
                     e+ + s+++ l++
      EFC39639.1  14 EEEVASLKNQLQN 26 
                     3333333333333 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 7.8e-05
                     EEEEE--STTHHHHHHHHHHCT.SEEEEE-S-HHHHHHHCT CS
  UDPG_MGDP_dh_N   2 kisviGlGYvGlvtaavlaeig.hevigvDideekvdklns 41 
                     +++v+GlG vG+v + +l + g  ++i+ D d    +++n+
      EFC39639.1  71 TVAVVGLGGVGAVVCEMLTRCGiGKLILFDFDIVSLANMNR 111
                     699*******************669*******999999987 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 3.2
                     S-SS--TTHHHHHHHH CS
  UDPG_MGDP_dh_N  43 kipiyepgLeelvkka 58 
                      +++++++L+el+k+ 
      EFC39639.1 386 LVNVENQDLDELMKQL 401
                     4677889999999986 PP

>> GBP_C  Guanylate-binding protein, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   5.2   0.00099         2     230     275 ..       2      47 ..       1      53 [. 0.90
   2 ?    4.7   0.0    0.0084        17     103     161 ..     122     182 ..     118     189 .. 0.90
   3 ?   -2.6   2.4       1.4   2.8e+03     224     252 ..     377     405 ..     311     406 .] 0.61

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00099
       GBP_C 230 eeqrmeakeksleehvkqLkekleeereklleeqerllekklkeqe 275
                 ++q+ e+++k+lee+v+ Lk++l+++++k+++e+ ++++++ k  +
  EFC39639.1   2 SQQQSEERIKQLEEEVASLKNQLQNQQQKVIREKISVISSEVKDDN 47 
                 589999********************************99988765 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.0084
       GBP_C 103 eslekkkedflkkneeasekkCsallqkl..seeleekikqgtfskpggyklfleekdkle 161
                 +++++ ke ++k n +   + Cs  + +l  +++ ++ i++g+  ++g+ +l l  +d++e
  EFC39639.1 122 TKVDASKETLSKINPDVVFETCSYNITSLdnFDTFMNTINTGNLLTNGKVDLVLSCVDNFE 182
                 688999******************9999966789*****************9998888776 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.4
       GBP_C 224 eekqkeeeqrmeakeksleehvkqLkekl 252
                 ++k+ +e++ ++ +++ l+e +kqL+e +
  EFC39639.1 377 HNKKVDEKELVNVENQDLDELMKQLNESM 405
                 22333344445555556666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (406 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2220  (0.123822); expected 358.6 (0.02)
Passed bias filter:                     1047  (0.058397); expected 358.6 (0.02)
Passed Vit filter:                       138  (0.00769703); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.76u 0.33s 00:00:01.09 Elapsed: 00:00:00.51
# Mc/sec: 2399.43
//
Query:       EFC39640.1  [L=708]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (708 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       695  (0.038764); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 4079.22
//
Query:       EFC39641.1  [L=292]
Description: rho GTPase activating protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.6e-35  120.2   0.0    1.5e-34  119.0   0.0    1.6  2  RhoGAP    RhoGAP domain


Domain annotation for each model (and alignments):
>> RhoGAP  RhoGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  119.0   0.0   8.5e-39   1.5e-34       1     148 [.      99     245 ..      99     250 .. 0.96
   2 ?   -3.0   0.0      0.33   5.9e+03      58      75 ..     262     281 ..     255     286 .. 0.55

  Alignments for each domain:
  == domain 1  score: 119.0 bits;  conditional E-value: 8.5e-39
                 BHHHHHHHHHHHHHTTTSTTTTTS-S-HHHHHHHHHHHHHTGGGCTTTTTSCHHHHHHHHHHHHHHSSSTTTTGGHHHHHHHHHTSSSHHHHHHHHHHH CS
      RhoGAP   1 PiivekcvefiekrgldtegiyRvsgskarvkelreafdkgkavdsdleeedvhavaslLKrfLrelpepLltkelyeelieaaksedeeerlealkel 99 
                 P+i ++c e +ek   d egi+Rv+gs+ +++++ + +d+g  v  +l+ ++ ++vaslLK+++relp+pLlt+e y++++++ ++e+ e+  e +k+l
  EFC39641.1  99 PLIAYHCFERLEKFV-DKEGIFRVPGSSVEIDKIVKDVDSGIVV--NLKTYSCNTVASLLKKYIRELPDPLLTYEGYNDWTKLSSMENTEQAREFMKKL 194
                 8999********975.****************************..8**************************************************** PP

                 HTTS-HHHHHHHHHHHHHHHHHHH..THHHH---HHHHHHHHHHHHHT-TS CS
      RhoGAP 100 lekLPkenrdtLryLlehLkrvae..nskenkMtaknLaivfaPtLlrpks 148
                 +  LP++nr+++ +Ll++L++++e  n +  +Mt +nLa +++ ++l+p+ 
  EFC39641.1 195 FIALPPCNRSLFISLLSLLRKISEppNIETSRMTESNLAFIWGMNILKPPG 245
                 ************************888888*****************9985 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.33
                 HHHHHH..HHHSSSTTTTGG CS
      RhoGAP  58 slLKrf..LrelpepLltke 75 
                  ++K++  Lre  ++L+ ++
  EFC39641.1 262 FCIKEYhrLREVYQQLVNEH 281
                 55555544555555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (292 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       607  (0.0338558); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.48
# Mc/sec: 1827.88
//
Query:       EFC39642.1  [L=1287]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.1e-34  118.5   2.4    3.1e-34  118.5   2.4    1.7  2  Pkinase        Protein kinase domain
      3e-17   62.8   0.1    5.5e-17   61.9   0.1    1.3  1  Pkinase_Tyr    Protein tyrosine kinase
    0.00041   20.4   0.0     0.0011   19.0   0.0    1.7  1  SPRY           SPRY domain
  ------ inclusion threshold ------
      0.076   12.5   0.1       0.22   11.0   0.1    1.7  1  YrbL-PhoP_reg  PhoP regulatory network protein YrbL
        2.9    7.4   5.1        9.7    5.7   5.1    1.8  1  EVI2A          Ectropic viral integration site 2A protein (EV


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  118.5   2.4   8.7e-38   3.1e-34      68     264 .]     416     634 ..     401     634 .. 0.75
   2 ?   -3.8   0.0       1.8   6.4e+03      49      75 ..    1198    1225 ..    1197    1239 .. 0.77

  Alignments for each domain:
  == domain 1  score: 118.5 bits;  conditional E-value: 8.7e-38
                 EESSEEEEEEE--TTEBHHHHHH........HHSS--HH........HHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE.............. CS
     Pkinase  68 eekdelylvleyveggeladlle........rkgslsee........eakkiakqilegleylHskgiiHrDlKpeNiLidekge.............. 136
                 ++ +++++++ey++g+ l+++++               +           +++ ++le ++ylH++++iHrDlKp+Ni+++ + +              
  EFC39642.1 416 KNFRYYCILMEYCSGKILDQFISdlneitkeS------KglktltmdVRFSWFIKLLEVMNYLHQNKVIHRDLKPQNIIVQYDSDnlknnfeeeirkit 508
                 5567889**********999999665555441......14444444155699*****************************633336666777788888 PP

                 EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT..SHH...HHHTTS CS
     Pkinase 137 lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg..etkeklpeasei 233
                 lKi+DFGlak+l +++++++++gt+ Y+APEv  + ey+ kvDv+slG+i++++ +  ++      ++ + + +++    ++++   +  +++ +++ +
  EFC39642.1 509 LKIIDFGLAKQLVHQNSTSTICGTRAYVAPEVKPGAEYDYKVDVYSLGIIFMQVSATLTVKD---FQQLIDQRARRYNIDFWLFMrsNHYFEFIHEHVF 604
                 ****************************************************9955544433...3333333333322223333324455666666666 PP

                 -HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 234 seeakdllkkllkkdpkkRltaeellqhpyl 264
                 +   k+++k +++  +++R +a+ell+hp++
  EFC39642.1 605 DIGSKRIVKMMVC-AREERKSAAELLEHPVI 634
                 6666776666655.6789**********975 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 1.8
                  HHHHHHHSCTTB--EEEEEEE.SSEEEE CS
     Pkinase   49 ikilkklkhpnivrlyevfee.kdelyl 75  
                  i++++++ h+ i  ++ev+++ +de +l
  EFC39642.1 1198 ISLHQRIMHSSIFPFIEVLSTpNDECLL 1225
                  688999************9993444444 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   61.9   0.1   1.5e-20   5.5e-17      75     199 ..     420     563 ..     410     584 .. 0.86

  Alignments for each domain:
  == domain 1  score: 61.9 bits;  conditional E-value: 1.5e-20
                  SEEEEEE--TTEBHHHHHHHT........CTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE..............TTEEEE-STTTH CS
  Pkinase_Tyr  75 pllivteyvkgGdLlkfLrkk........ekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse..............nkvvkisDfGLa 150
                   ++i++ey++g  L++f+ +           ++lt++  +s+ +++ + m+yL+++k++Hrdl  +N++++               + + ki DfGLa
   EFC39642.1 420 YYCILMEYCSGKILDQFISDLneitkeskGLKTLTMDVRFSWFIKLLEVMNYLHQNKVIHRDLKPQNIIVQYdsdnlknnfeeeirKITLKIIDFGLA 517
                  579***************99999999887788999999*********************************99999*******998889********* PP

                  EETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHHHHH CS
  Pkinase_Tyr 151 rdiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsfGvllwEif 199
                  +++ ++++++   +      ++apE+    ++  k Dv+s G++ + + 
   EFC39642.1 518 KQLVHQNSTS---TICGTRAYVAPEVKPGAEYDYKVDVYSLGIIFMQVS 563
                  ***4444443...33445679**********************998774 PP

>> SPRY  SPRY domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.0   3.1e-07    0.0011       2     105 ..    1108    1213 ..    1107    1230 .. 0.65

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 3.1e-07
                  EEEEEEETCCTSSEEEEEE......EETTSSSSSTSSSTSSTTEEEEETETTEEEEETESCEEEESSSSTTSEEEEEEETTTTEEEEEETTEEE..E CS
        SPRY    2 hyfevkiqsaeggsisvGl......ateqtdlsdksgegddrgswglcgdngtrtsaeqskaygkqparegdviGvalDleegelsFtkngknl..g 90  
                  +y+ev+i++  ++++s+Gl      + +++  +++ +   ++g +g+     ++  +   k+ +   a+ gd+iG++l +e+ge+ Ft ng+ l   
  EFC39642.1 1108 FYYEVQIHRLISSKVSIGLmarsniSENNCVDRKYAF-QAQEG-FGCIMSADKK--EILYKELEI-IAHCGDTIGCGL-TEQGEVYFTMNGIFLfsI 1198
                  8******************544444444444333333.23333.3333322222..345566666.8899********.566*********988544 PP

                  EEEESTTTSSEEEEE CS
        SPRY   91 vaFrnvrgaelfPvv 105 
                     + + ++  fP++
  EFC39642.1 1199 SLHQRIMHSSIFPFI 1213
                  444445555677766 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   6.1e-05      0.22     127     157 ..     464     494 ..     445     500 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 6.1e-05
  YrbL-PhoP_reg 127 aLdefleelldnhivtndlsakNivvkknse 157
                    +L e +++l +n+++ +dl+++Ni+v+++s 
     EFC39642.1 464 KLLEVMNYLHQNKVIHRDLKPQNIIVQYDSD 494
                    5778899*******************99886 PP

>> EVI2A  Ectropic viral integration site 2A protein (EVI2A)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   5.1    0.0027       9.7      20     108 ..     113     202 ..      96     226 .. 0.72

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0027
       EVI2A  20 llpqtkanytelwavnetawds.iiqnktngrnksensntnpvtpevdkks.kstetletetsspsvslapkseeelttpsvvrnsssttq 108
                  + q ++n++ ++++n+t++++  + n++  +n+++n ntn + + +  +  +  + ++++ + +   l  +s ++ ++ps+ ++ s+t +
  EFC39642.1 113 NSNQQQPNQNGFPQTNTTSSSPpLFLNHQ-QHNNTRNVNTNQQQAYFPSQFhNHHNYPQVPLTFTPSPLYVQSPSNSYVPSPSNSYSTTGT 202
                 577999**********9998862566776.7777788888887777655543888999999887777788888888899985544443333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1287 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       899  (0.0501422); expected 358.6 (0.02)
Passed bias filter:                      482  (0.0268838); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.99u 0.33s 00:00:01.32 Elapsed: 00:00:00.55
# Mc/sec: 7003.24
//
Query:       EFC39643.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.023   13.8   2.5      0.038   13.1   2.5    1.4  1  FAM199X   Protein family FAM199X
        2.6    7.6  25.2      0.083   12.5  17.4    2.1  2  SR-25     Nuclear RNA-splicing-associated protein
        3.3    6.8  17.7        5.2    6.2  17.7    1.2  1  Med3      Mediator complex subunit 3 fungal


Domain annotation for each model (and alignments):
>> FAM199X  Protein family FAM199X
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   2.5   6.3e-06     0.038     178     238 ..     413     479 ..     376     505 .. 0.71

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 6.3e-06
     FAM199X 178 kqvrnyikehsprqra...sstreswkrssyssastsgvsaasssna...smvssassstasvgssa 238
                 k++ nyik+ + +  +   +st ++ k s++ + + +   +asss+    s  ssasssta++++++
  EFC39643.1 413 KDILNYIKQLGDKSTPvatTSTSNGKKPSKHHTKAPATQKGASSSTEkseSTTSSASSSTATTTATT 479
                 7899****98887765211566777788888777666666666665500155555555555554443 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.9      0.16   9.3e+02      30      51 ..      12      33 ..       2      51 .. 0.44
   2 ?   12.5  17.4   1.4e-05     0.083      42     115 ..     432     504 ..     405     508 .] 0.43

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.16
       SR-25 30 sssasksqsrkassasekeeer 51
                sss++++q++++ +++e e+++
  EFC39643.1 12 SSSSAEEQKEEEEQTAEDEAQD 33
                2222222222222333333333 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 1.4e-05
       SR-25  42 ssasekee.erskekkkkkrrrssssssssssssssssssssssssdd..rkkrgkkkdkkkkkkkkkkkkkkekkk 115
                 +s+s+ ++  +++ k+  +++  sss+++s s++ss+sss++ ++  +   ++++ +k++ ++kkk+       kk 
  EFC39643.1 432 TSTSNGKKpSKHHTKAPATQKGASSSTEKSESTTSSASSSTATTTATTegGEQKQPNKRRNHHKKKQ----AFVKKE 504
                 3344444323333344444444444444444443333333333333331233333333222222222....222222 PP

>> Med3  Mediator complex subunit 3 fungal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2  17.7   0.00087       5.2     135     213 ..     426     500 ..     418     508 .] 0.60

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.00087
        Med3 135 asvvnstpssaastPtttatPgantktaakslpapnata.......tigtptnsaaaaattatttssqakkPrkPrqtkkaaakaa 213
                  + v++t +s +  P    t   +t++           a          t + s+++a+ttatt + + k+P k r   k + +a 
  EFC39643.1 426 STPVATTSTSNGKKPSKHHTKAPATQKG----------AsssteksESTTSSASSSTATTTATTEGGEQKQPNKRRNHHK-KKQAF 500
                 3344555555555555544443333333..........13333332555666888899999999************9877.34443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2121  (0.1183); expected 358.6 (0.02)
Passed bias filter:                      629  (0.0350828); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.79u 0.33s 00:00:01.12 Elapsed: 00:00:00.56
# Mc/sec: 2744.77
//
Query:       EFC39644.1  [L=294]
Description: abc transporter B family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.5e-33  115.0   0.0      6e-33  114.3   0.0    1.4  1  ABC_tran     ABC transporter
      2e-07   30.7   2.0     0.0001   21.8   0.1    2.3  2  SMC_N        RecF/RecN/SMC N terminal domain
    0.00017   21.3   0.1    0.00044   19.9   0.1    1.7  1  AAA_29       P-loop containing region of AAA domain
    0.00038   20.9   0.3       0.15   12.5   0.1    2.3  2  AAA          ATPase family associated with various cellular a
     0.0005   20.0   0.0     0.0015   18.5   0.0    1.7  1  RsgA_GTPase  RsgA GTPase
    0.00066   20.1   0.9     0.0041   17.5   0.9    2.0  1  AAA_16       AAA ATPase domain
     0.0022   18.3   0.3      0.097   12.9   0.0    2.3  2  AAA_22       AAA domain
     0.0039   16.9   1.1       0.11   12.1   0.0    2.3  2  AAA_30       AAA domain
      0.004   16.9   0.0     0.0088   15.8   0.0    1.5  2  AAA_15       AAA ATPase domain
     0.0054   16.7   0.2      0.093   12.7   0.0    2.5  2  AAA_5        AAA domain (dynein-related subfamily)
  ------ inclusion threshold ------
      0.011   15.7   0.1       0.13   12.1   0.0    2.4  3  Rad17        Rad17 P-loop domain
      0.013   14.4   0.6      0.018   13.8   0.0    1.5  2  ABC_ATPase   Predicted ATPase of the ABC class
      0.015   14.6   0.0       0.11   11.7   0.0    2.1  2  Zeta_toxin   Zeta toxin
      0.015   15.8   0.5      0.037   14.6   0.1    2.0  1  AAA_18       AAA domain
      0.018   14.8   0.4        1.3    8.8   0.2    2.3  2  AAA_21       AAA domain, putative AbiEii toxin, Type IV TA sy
      0.027   14.6   0.2       0.16   12.1   0.0    2.0  2  DUF87        Helicase HerA, central domain
      0.043   13.3   0.1       0.14   11.7   0.0    1.9  2  AAA_7        P-loop containing dynein motor region
      0.047   12.8   0.0      0.088   12.0   0.0    1.4  1  G-alpha      G-protein alpha subunit
      0.073   12.8   0.2       0.35   10.6   0.0    2.1  2  AAA_24       AAA domain
      0.086   13.1   0.6       0.59   10.4   0.6    2.1  1  SbcCD_C      Putative exonuclease SbcCD, C subunit
        0.1   12.1   0.2          4    7.0   0.0    2.2  2  AAA_25       AAA domain
       0.11   12.4   0.1       0.93    9.4   0.0    2.3  2  APS_kinase   Adenylylsulphate kinase


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  114.3   0.0   7.3e-36     6e-33       3     137 .]      33     191 ..      31     191 .. 0.88

  Alignments for each domain:
  == domain 1  score: 114.3 bits;  conditional E-value: 7.3e-36
                 EEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGG.B-HHHCCHCEEEE-SS--S-TTSBHHHH..................... CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxx..................... RF
    ABC_tran   3 nvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlke.qeleslrkeigvlpqepqlfpeltvren..................... 79 
                 + sl++k g+ +a+vG++G+GKSt++ ll + ++p++G+i++dg d+ e +++   r+ +g+++qep lf ++ ++ n                     
  EFC39644.1  33 DFSLDIKSGQQIALVGPSGSGKSTIVGLLEKFYTPNKGTIKIDGVDVAElDPMWLHRNCLGIVSQEPVLFAGT-IKYNiayallgpndsvesgkvvtme 130
                 789**********************************************999*********************.99999*******9999999998777 PP

                 .....HHHTCHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 .....xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  80 .....esdeeiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137
                      +++++++ ++   +l+e+ dt++++++ sLSgGqkqr+a+arall++pk+lllDE+t+
  EFC39644.1 131 qvenaAKRANAHSFIM--DLPEKYDTILGEKGVSLSGGQKQRIAIARALLQDPKILLLDEATS 191
                 6653333333444444..444467*************************************96 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.2    0.0023       1.9      25      41 ..      42      58 ..      31      66 .. 0.84
   2 !   21.8   0.1   1.3e-07    0.0001     136     210 ..     162     232 ..     123     245 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0023
                SEEEEEESTTSSHHHHH CS
                xxxxxxxxxxxxxxxxx RF
       SMC_N 25 sftaivGpNGSGKsnll 41
                +  a+vGp GSGKs ++
  EFC39644.1 42 QQIALVGPSGSGKSTIV 58
                45789*********997 PP

  == domain 2  score: 21.8 bits;  conditional E-value: 1.3e-07
                 CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SSHHHCCC-SCEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 136 lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislreemlekadklvg 210
                 +LSgG+k+ +a+a        +   + llDe  +aLD +  + v   l+e  k    i+i++r +++ ++d ++ 
  EFC39644.1 162 SLSGGQKQRIAIARA----LLQDPKILLLDEATSALDTESERLVQAALDELMKGRTTICIAHRLTTVINSDVICV 232
                 69*****99888754....345556899**************************************999987654 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.1   5.3e-07   0.00044      16      40 ..      35      59 ..      27      73 .. 0.75

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 5.3e-07
      AAA_29 16 tieidlkgatlltGpsGsGKSTllD 40
                +++i+  + + l+GpsGsGKST++ 
  EFC39644.1 35 SLDIKSGQQIALVGPSGSGKSTIVG 59
                5667644499*************95 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5   0.0     0.013        11       2      18 ..      45      61 ..      44      90 .. 0.80
   2 !   12.5   0.1   0.00018      0.15      17      98 ..     134     214 ..     115     240 .. 0.70

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.013
                EEESSTTSSHHHHHHHH CS
         AAA  2 llyGppGtGKTllakav 18
                 l+Gp G GK++++  +
  EFC39644.1 45 ALVGPSGSGKSTIVGLL 61
                699*********99765 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 0.00018
                 HHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTS.....TSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTT CS
         AAA  17 avakelgvefleisgsellskyvgesekkirelfkeakeka.....kpsilfiDEidalaksrsgseseeeervvnqLlteldgvkk 98 
                   ak ++++ + ++++e  + ++ge+  ++++  k+  + a     +p+il++DE+ +   ++      +e+ v+++L + ++g ++
  EFC39644.1 134 NAAKRANAHSFIMDLPEKYDTILGEKGVSLSGGQKQRIAIArallqDPKILLLDEATSALDTE------SERLVQAALDELMKGRTT 214
                 334445799999999999999888877666655554222222345779***********9999......777788888888877766 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   0.0   1.8e-06    0.0015      64     120 ..       5      62 ..       2      75 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 1.8e-06
                  HHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHC CS
  RsgA_GTPase  64 eleelkeelealgyevllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinall 120
                  ++e++k ++e +g+++ + s  +++ +++ +  +k+ + ++lvG+SG GKSt++  l 
   EFC39644.1   5 KIEQVKGDIEITGVDFAYPSRPNTNVMTDFSLDIKSgQQIALVGPSGSGKSTIVGLLE 62 
                  478999999999*********999*******999998****************98886 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.9   5.1e-06    0.0041      25     161 ..      42     207 ..      34     226 .. 0.54

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 5.1e-06
      AAA_16  25 elvllsGesGvGKsslvrellralekd...................ggiflrgkcdqlesaipy..........salaqalareellrqlldeaesael 94 
                 + + l+G+sG+GKs++v  l + ++ +                   +                +          + +a ++ +  +  +ll + +s e 
  EFC39644.1  42 QQIALVGPSGSGKSTIVGLLEKFYTPNkgtikidgvdvaeldpmwlH----------------RnclgivsqepVLFAGTI-KYNIAYALLGPNDSVES 123
                 5689*************999998888854444444444444222220................122222222212266666.44666666666555444 PP

      AAA_16  95 eawrekleeala.......................avpelagaeasrllellkrllallsrderplvlvlDdlq.wadeaslqllaaLlrl 161
                 +   +  + + a                        + +l+g +++r++ +  r+l      ++p +l+lD++   +d++s  l +a l++
  EFC39644.1 124 GKVVTMEQVENAakranahsfimdlpekydtilgeKGVSLSGGQKQRIAIA--RAL-----LQDPKILLLDEATsALDTESERLVQAALDE 207
                 444444444433444444444444444444444333333333333333333..333.....245667777777755566666666666655 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9   0.0   0.00012     0.097       5      30 ..      41      66 ..      37      94 .. 0.81
   2 ?    3.1   0.1      0.13   1.1e+02      80     109 ..     166     205 ..     120     225 .. 0.60

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 0.00012
      AAA_22  5 agilvvtGesGtGKTtllrrlleqld 30
                 + ++++G+sG+GK+t +  l + ++
  EFC39644.1 41 GQQIALVGPSGSGKSTIVGLLEKFYT 66
                56789***********9999888875 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.13
      AAA_22  80 ealeqalrarav...ielliiDEaqh.lr..s....eeal 109
                  + ++ + ara    +++l++DEa   l+  s    ++al
  EFC39644.1 166 GQKQRIAIARALlqdPKILLLDEATSaLDteSerlvQAAL 205
                 3333333334434455699999998877664333444444 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.1   0.0   0.00014      0.11      20      49 ..      43      72 ..      36      81 .. 0.82
   2 ?    3.1   0.2     0.084        68      81     115 ..     168     207 ..     123     215 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00014
      AAA_30 20 vavltGpAGtGKttalkalreaweaaggrv 49
                  +l+Gp G+GK+t+++ l++ ++ ++g++
  EFC39644.1 43 QIALVGPSGSGKSTIVGLLEKFYTPNKGTI 72
                56899***************9999886554 PP

  == domain 2  score: 3.1 bits;  conditional E-value: 0.084
      AAA_30  81 k.....grarlepgtllivDEagmvdtkqlaallkaaeka 115
                 k     +ra l++ ++l+ DEa  +  ++ ++l++aa ++
  EFC39644.1 168 KqriaiARALLQDPKILLLDEATSALDTESERLVQAALDE 207
                 044445556677789*******999999999999998764 PP

>> AAA_15  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.0   1.1e-05    0.0088      16      65 ..      33      79 ..      31      90 .. 0.84
   2 ?   -3.5   0.0       7.7   6.3e+03     216     238 ..     245     269 ..     231     289 .. 0.54

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.1e-05
      AAA_15 16 dveidlsee.ltvliGkNnsGKSsilealdlFlnnkekknkkvikiekedl 65
                d+++d+++     l+G+ +sGKS+i+ +l++F + +    k +iki+  d+
  EFC39644.1 33 DFSLDIKSGqQIALVGPSGSGKSTIVGLLEKFYTPN----KGTIKIDGVDV 79
                6777888777889********************988....77888877665 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 7.7
      AAA_15 216 sllgklkekileealqekl..eeel 238
                 s l+k+++ i+++ +++++  +ee+
  EFC39644.1 245 SELIKIPQGIYRNLAEKQMifTEEK 269
                 4455555555554333333442222 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.0   0.00011     0.093       3      25 ..      45      67 ..      43      76 .. 0.82
   2 ?    1.2   0.0      0.41   3.3e+02      20      78 ..     136     193 ..     123     217 .. 0.64

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 0.00011
                EEE--SSSSHHHHHHHGGGGBS- CS
       AAA_5  3 lLvGppGtgKselaerlaaalnr 25
                 LvGp+G+gKs+++  l ++++ 
  EFC39644.1 45 ALVGPSGSGKSTIVGLLEKFYTP 67
                69***************999843 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.41
                 GGGBS--EEEEE--TT--HHHHH--B--..........--------G-SEEEEESGGG-- CS
       AAA_5  20 aaalnreveyvqltrdtteedlkgrreik.ngttslvdsplvraaregeilvlDEverae 78 
                 a++ n+  +++ l++  ++++++g+  ++ +g+++ +  ++    + ++il+lDE + a 
  EFC39644.1 136 AKRANAHSFIMDLPE--KYDTILGEKGVSlSGGQKQRIAIARALLQDPKILLLDEATSAL 193
                 444466666666666..5566666666664444444444444445699999999988775 PP

>> Rad17  Rad17 P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   0.00016      0.13      39      71 ..      35      67 ..      27      85 .. 0.80
   2 ?    0.8   0.0      0.51   4.1e+02     126     165 ..     174     213 ..     125     228 .. 0.74
   3 ?   -2.9   0.0       6.5   5.3e+03      19      37 ..     261     279 ..     255     284 .. 0.73

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00016
       Rad17 39 vLesrkkriLLisGPsGCgkstvvkvLskelgi 71
                +L+ +  + + + GPsG gkst+v  L k +++
  EFC39644.1 35 SLDIKSGQQIALVGPSGSGKSTIVGLLEKFYTP 67
                5666666767789**************998766 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.51
       Rad17 126 GddlrtdkklilvedlPnkfyrdsdalrevirkylrssea 165
                    l  d k++l+++  +   ++s++l +  +  l+ +++
  EFC39644.1 174 ARALLQDPKILLLDEATSALDTESERLVQAALDELMKGRT 213
                 4556678899999999999999998888877777766665 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 6.5
       Rad17  19 eelavhkkkieevkewlka 37 
                 +++    +k+e+v++ ++ 
  EFC39644.1 261 KQMIFTEEKVEDVEDVMDV 279
                 4556667899999998875 PP

>> ABC_ATPase  Predicted ATPase of the ABC class
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.1       2.6   2.1e+03     242     264 ..      38      61 ..      36      63 .. 0.74
   2 ?   13.8   0.0   2.2e-05     0.018     298     353 ..     137     193 ..     126     246 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.6
                 E-SS.EEEEEE-TTSSHHHHHHHH CS
  ABC_ATPase 242 ipkG.vtlIvGggfhGKsTLLeAl 264
                 i+ G  +++vG+   GKsT++  l
  EFC39644.1  38 IKSGqQIALVGPSGSGKSTIVGLL 61 
                 56665567899999*****87655 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 2.2e-05
                 EEE--TTTB---CCC--ST.TEEESS--HHHHHHHHHHHHHHTT-SEEEEEGGGS-H CS
  ABC_ATPase 298 kgvDispFinnLPegkdtt.kfstedASGStsqAanimealeagakllLiDEDtsAt 353
                 k+++  +Fi +LPe+ dt         SG   q  +i++al  + k+lL+DE tsA 
  EFC39644.1 137 KRANAHSFIMDLPEKYDTIlGEKGVSLSGGQKQRIAIARALLQDPKILLLDEATSAL 193
                 6788999***********965566678****************************96 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00014      0.11      19      60 ..      44      85 ..      32      90 .. 0.89
   2 ?    0.1   0.0       0.5     4e+02      73     112 ..     190     232 ..     186     252 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00014
  Zeta_toxin 19 illgGqpGAGKselaellkdelerqgnvvrldpDdlRelhPe 60
                i l+G +G+GKs++  ll++  +++++ +++d+ d+ el P+
  EFC39644.1 44 IALVGPSGSGKSTIVGLLEKFYTPNKGTIKIDGVDVAELDPM 85
                7799****************************9888777775 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.5
  Zeta_toxin  73 seltqkdaselvekllqeaiengyniive...gtlrspdvvkk 112
                  +  + ++ +lv+ +l+e+++ +  i +    +t  + dv++ 
  EFC39644.1 190 TSALDTESERLVQAALDELMKGRTTICIAhrlTTVINSDVICV 232
                 55667789999999****9999998876533345555555555 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.1   4.5e-05     0.037       1      25 [.      44      70 ..      44     147 .. 0.72

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 4.5e-05
      AAA_18  1 IlltGtpGvGKttlakeLskrlgf....g 25
                I+l G++G+GK+t+   L+k   +    g
  EFC39644.1 44 IALVGPSGSGKSTIVGLLEKF--YtpnkG 70
                89****************663..234463 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.8   0.2    0.0015       1.3       3      19 ..      45      61 ..      44      80 .. 0.86
   2 ?    4.2   0.0      0.04        33     236     272 ..     162     195 ..     124     225 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.8 bits;  conditional E-value: 0.0015
      AAA_21  3 vliGpNgsGKSnLLdal 19
                +l+Gp gsGKS++  +l
  EFC39644.1 45 ALVGPSGSGKSTIVGLL 61
                79**********97766 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.04
      AAA_21 236 elSdGtkrllalltallralkkgsllliDEpEngLHP 272
                 +lS G+k+ +a++ all+++   ++ll+DE  + L+ 
  EFC39644.1 162 SLSGGQKQRIAIARALLQDP---KILLLDEATSALDT 195
                 57999999999999999999...9******8888876 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   0.00019      0.16      14      48 ..      34      65 ..      24      75 .. 0.74
   2 ?    0.3   0.0      0.74     6e+02      52     130 ..     140     210 ..     123     285 .. 0.59

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00019
       DUF87 14 vyldlnklvtrHlAilgsTGsGKSntvavLleell 48
                 +ld+++   + +A +g +GsGKS+ v++L e+ +
  EFC39644.1 34 FSLDIKS--GQQIALVGPSGSGKSTIVGLL-EKFY 65
                5677744..4889**************976.5555 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.74
       DUF87  52 gatililDpHGEYgkalekllsekvkvitpspsakdkelkinpwsldpeelldlleeddkpaaavqrsvleealdqaka 130
                 +a+  i D    Y ++l     ek + ++     +++++ i  ++l+   +l l e  + ++ ++++++++ ald++ +
  EFC39644.1 140 NAHSFIMDLPEKYDTIL----GEKGVSLSGG---QKQRIAIARALLQDPKILLLDEA-TSALDTESERLVQAALDELMK 210
                 44555555555555555....3333333332...34445555555554444444333.444444455555555555543 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   0.00017      0.14      28      51 ..      36      59 ..      23      74 .. 0.80
   2 ?   -2.7   0.0       4.4   3.6e+03     125     148 ..     254     278 ..     245     289 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00017
       AAA_7 28 lllknkkpvllvGptGtGKtviik 51
                l +k+++++ lvGp+G+GK++i+ 
  EFC39644.1 36 LDIKSGQQIALVGPSGSGKSTIVG 59
                557999***************986 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 4.4
       AAA_7 125 llRqlldyggwYdrkkl.efkeikd 148
                 + R l ++++++  +k+ +++++ d
  EFC39644.1 254 IYRNLAEKQMIFTEEKVeDVEDVMD 278
                 4566666666666666434444444 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   0.00011     0.088      23      50 ..      41      68 ..      25      97 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 0.00011
                EEEEEEEESTTSSHHHHHHHHHHHCS-- CS
     G-alpha 23 evkllllGqseSGKsTilkqlkllykkg 50
                  ++ l+G s+SGKsTi+  l+++y+++
  EFC39644.1 41 GQQIALVGPSGSGKSTIVGLLEKFYTPN 68
                45899*****************999875 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00043      0.35       2      22 ..      41      61 ..      40      84 .. 0.82
   2 ?   -0.8   0.0       1.3     1e+03     107     133 ..     193     222 ..     167     229 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00043
      AAA_24  2 klkiliyGpsgiGKTtlakel 22
                +++i+++Gpsg+GK+t++  l
  EFC39644.1 41 GQQIALVGPSGSGKSTIVGLL 61
                6789************98766 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.3
      AAA_24 107 laeefrrllkk.lqelrk..nvifiahekt 133
                 l +e  rl+++ l+el k  + i+iah  t
  EFC39644.1 193 LDTESERLVQAaLDELMKgrTTICIAHRLT 222
                 566777777777888888888888888766 PP

>> SbcCD_C  Putative exonuclease SbcCD, C subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.6   0.00073      0.59      54      85 ..     178     202 ..     135     207 .. 0.73

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00073
     SbcCD_C  54 yssaegrepalrlvfLDEAFsklDeesiatll 85 
                 +       +++++++LDEA s lD es + + 
  EFC39644.1 178 L-------QDPKILLLDEATSALDTESERLVQ 202
                 3.......3489*************9977665 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0    0.0049         4      32      50 ..      40      58 ..      21      61 .. 0.88
   2 ?    3.0   0.1     0.083        68      98     184 ..     138     224 ..     117     226 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0049
      AAA_25 32 agelallaGapgtGKttla 50
                 g  ++l+G++g+GK+t++
  EFC39644.1 40 SGQQIALVGPSGSGKSTIV 58
                567789***********85 PP

  == domain 2  score: 3.0 bits;  conditional E-value: 0.083
      AAA_25  98 rddarllvldlagveslpLfakdrggtl..ltadvdaleaaieevegvrlvviDplsralggdensnsdv..galvealeriarrtgaavl 184
                 r++a+ +++dl+++ ++ L +k+   +l   + +  a+++a+ +  +++ + +D  ++al+ ++++  ++  ++l++    i+ +++ +++
  EFC39644.1 138 RANAHSFIMDLPEKYDTILGEKG--VSLsgGQKQRIAIARALLQ--DPKILLLDEATSALDTESERLVQAalDELMKGRTTICIAHRLTTV 224
                 45677788888777666666543..2221123333356666666..79**********999966655443368888888888888777765 PP

>> APS_kinase  Adenylylsulphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0       0.9   7.4e+02     131     151 ..      13      32 ..       7      37 .. 0.71
   2 ?    9.4   0.0    0.0011      0.93       3      38 ..      42      76 ..      40      82 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.9
                 SSSHTTTSS-----SS-SEEE CS
  APS_kinase 131 ikeftGidspYeaPenpelvv 151
                 i e+tG+d +Y +  n++++ 
  EFC39644.1  13 I-EITGVDFAYPSRPNTNVMT 32 
                 4.69*******6655655554 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.0011
                EEEEEESSTTSSHHHHHHHHHHHHHHTT--EEEEEH CS
  APS_kinase  3 vvvwltGlsgsGKstianalekkLvekgisvylLdG 38
                  + l G sgsGKsti   lek   + ++ ++ +dG
  EFC39644.1 42 QQIALVGPSGSGKSTIVGLLEKF-YTPNKGTIKIDG 76
                568899***********999964.444445555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (294 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       647  (0.0360868); expected 358.6 (0.02)
Passed bias filter:                      490  (0.02733); expected 358.6 (0.02)
Passed Vit filter:                        86  (0.0047967); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              22  [number of targets reported over threshold]
# CPU time: 0.63u 0.36s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 1659.23
//
Query:       EFC39645.1  [L=429]
Description: elongation factor 1 alpha [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    9.5e-29  100.3   0.0    1.4e-28   99.8   0.0    1.2  1  GTP_EFTU     Elongation factor Tu GTP binding domain
    4.4e-19   68.8   0.0      9e-19   67.8   0.0    1.6  1  GTP_EFTU_D3  Elongation factor Tu C-terminal domain
    1.9e-10   41.0   0.4      2e-09   37.7   0.0    2.7  3  GTP_EFTU_D2  Elongation factor Tu domain 2
      0.001   19.0   0.1      0.002   18.0   0.1    1.6  1  GTP_EFTU_D4  Elongation factor Tu domain 4
     0.0021   18.1   0.0     0.0068   16.5   0.0    1.9  1  MMR_HSR1     50S ribosome-binding GTPase


Domain annotation for each model (and alignments):
>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   99.8   0.0   3.9e-32   1.4e-28       3     183 ..       6     207 ..       4     217 .. 0.81

  Alignments for each domain:
  == domain 1  score: 99.8 bits;  conditional E-value: 3.9e-32
                 EEEEEEEESTTSSHHHHHHHHHHHTTSSCHHHHHH...HHHST............HCHSHHHHHHTSCSSCEEEEEETTCSSEEEEEEEESSSGGGHHH CS
    GTP_EFTU   3 irnigiighvDhGKtTLtdrLlyktgaiskkgeka...eeerv............lDtlkeErergiTiksaaisleketkkylinliDtPGHvdFske 86 
                 ++ i+++g vD+GK+TL +rLl+++g+++++  ++   e+               l ++ eE +rg +i+ a    e  tk+++in+iD+P  + F+k 
  EFC39645.1   6 TLSIVFLGRVDSGKSTLAGRLLHSLGTVNDSIIERlqvES--RefgfakthyanvLSRTREETRRGRSIHLAYSRAE--TKHFHINIIDAP-AAPFVKS 99 
                 67899**********************9998777765422..2457888888888**********************..************.799**** PP

                 HHHHHHT-SEEEEEEETTTB.STHHHHHHHHHHHHTTTE..EEEEEESCGST.....HHHHHHHHHHHHHHHHHHHHHHHHHHHTTTTTEEEEEEBTTT CS
    GTP_EFTU  87 virglrvlDgavlvvdaveG.vepqteevlrlalkegvp..iivfiNKmDrl.....kaelkeiveevkqklsrkeeklekygekgekevpvvfgSalk 177
                 +irg++++++ ++v+da++G  e+qt + + l  +   +  +i+++NKmD +     ++++kei++   +k+       +  g+kg+    ++++Sa++
  EFC39645.1 100 MIRGISQANVGIIVLDAESGsLEQQTVKEILLTTQSLGEfqLIFCVNKMDSMfvansETKFKEIQNSEMSKI------YKMHGYKGD--PLLIPVSAWT 190
                 ********************888888877777766544345***********97777777777777777676......555577764..679******* PP

                 TBTHH...........H CS
    GTP_EFTU 178 gegvk...........t 183
                 g++v            t
  EFC39645.1 191 GDNVVdccdmkwykgpT 207
                 **999444444444444 PP

>> GTP_EFTU_D3  Elongation factor Tu C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   67.8   0.0   2.5e-22     9e-19       5     111 ..     318     421 ..     314     422 .. 0.89

  Alignments for each domain:
  == domain 1  score: 67.8 bits;  conditional E-value: 2.5e-22
                  ECCEEEEEEESSS..SS-BSTT-EEEEESSS-EEEEEEEEEEECCSSTTSB-BSS-SSCCSTT-CEEEEEEECCEEEE--TTTHCCCCEEEEECTTCE CS
  GTP_EFTU_D3   5 htkfeAqvyilekerhtpitagYrpvlyirtadvtgkvveLlskldkktekvsekkpefvkpGdnvivevelikpialekgseypqlGrFaiReggrT 102
                  +  f+A++++l++   t+i  gY+p +++++ +  ++++++ +  +   + + +++p+ ++ G+ + v +++ +pi le+ +++p+lG+F +R++g  
   EFC39645.1 318 VLCFKAEIIVLKR---TAIKIGYKPTFHCHSLQTRCQFIQFYECSKMPLKTERKENPSELRRGQVARVLLKPDNPISLETLQNIPKLGKFIMRDNGCV 412
                  567*********9...*************************65444433444459******************************************* PP

                  EEEEEEEEE CS
  GTP_EFTU_D3 103 vaaGvvtei 111
                    +G+v++i
   EFC39645.1 413 CVVGIVKDI 421
                  ******998 PP

>> GTP_EFTU_D2  Elongation factor Tu domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.0       2.9     1e+04      50      59 ..     105     114 ..      96     120 .. 0.74
   2 ?   -0.4   0.0      0.43   1.5e+03      21      43 ..     153     176 ..     145     188 .. 0.81
   3 !   37.7   0.0   5.7e-13     2e-09       3      73 ..     241     307 ..     240     308 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.9
                  TTSEEEEEEE CS
  GTP_EFTU_D2  50 aganaGviva 59 
                    an+G+iv+
   EFC39645.1 105 SQANVGIIVL 114
                  5678888886 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.43
                  EECTCTTSEE.EEEEEEEEEEETE CS
  GTP_EFTU_D2  21 ilgndtskke.ivtrissletfhe 43 
                  +  ++t+ ke + ++ s+++++h+
   EFC39645.1 153 VANSETKFKEiQNSEMSKIYKMHG 176
                  433778888899999****99997 PP

  == domain 3  score: 37.7 bits;  conditional E-value: 5.7e-13
                  EEEEEEEESEEETTEEEEEECTCTTSEEEEEEEEEEEEETEEESEEETTSEEEEEEEESSCCSGSSTTCEE CS
  GTP_EFTU_D2   3 valgrvysGtlkkGdevrilgndtskkeivtrissletfhededeavaganaGvivaikgledaiivGdtl 73 
                  +++g+++sG+lk + ++r  +n   kk  +++i s+e f+e++ ea ag+ + +++  +  +d ++ G++l
   EFC39645.1 241 IVFGKIESGILKLDSKLRCTPN---KKVPHVTIESIEIFRERVSEAKAGQFVTIKLQNVRRSD-VKSGMVL 307
                  79*****************664...55678*********************************.******9 PP

>> GTP_EFTU_D4  Elongation factor Tu domain 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.0   0.1   5.6e-07     0.002       8      72 ..     230     295 ..     224     308 .. 0.85

  Alignments for each domain:
  == domain 1  score: 18.0 bits;  conditional E-value: 5.6e-07
                  EEEEEEETCCCEEEEEEEEEEEEETT-EEEETTE.EEE..EEEEEEETTEEESEEETT-EEEEEEES CS
  GTP_EFTU_D4   8 lpgvvfrrsdpaivGvevlgGvikpgvklikedGrevG..eilqiqdkgkkleeakaGqevaisieg 72 
                  + +v ++r +p++ G ++ +G++k + kl  +  ++v   +i +i+  +++++eakaGq v i +++
   EFC39645.1 230 ISKVYNKRGKPIVFG-KIESGILKLDSKLRCTPNKKVPhvTIESIEIFRERVSEAKAGQFVTIKLQN 295
                  5677899********.*************999999997225789*******************9976 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0   1.9e-06    0.0068       2     102 ..       9     131 ..       8     155 .. 0.55

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1.9e-06
                 EEEEESTTSSHHHHHHHHHT......................STEEESSSTTSSSSEEEEEEEETTEE............................... CS
    MMR_HSR1   2 vaivGrpNvGKStLinaltg......................ekaivsdkpgtTrdinegrvklkgke............................... 47 
                 ++++Gr  +GKStL  +l+                       +k                       +                               
  EFC39645.1   9 IVFLGRVDSGKSTLAGRLLHslgtvndsiierlqvesrefgfAKT----------------------Hyanvlsrtreetrrgrsihlaysraetkhfh 85 
                 899****************73334433333333333333323111......................11222223333444444444555555555555 PP

                 EEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETTTTCSHHHHHHHHHHHH CS
    MMR_HSR1  48 ielvDtpGliegaseekglgkaflaleeadlillvvdaseeklkpldeeleelle 102
                 i+++D p           ++  ++ + +a++ ++v+da++++l++  ++++e+l 
  EFC39645.1  86 INIIDAPA-AP------FVKSMIRGISQANVGIIVLDAESGSLEQ--QTVKEILL 131
                 ********.44......2455555566799999999988554433..44444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (429 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       409  (0.0228122); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2497.90
//
Query:       EFC39646.1  [L=570]
Description: hypothetical protein NAEGRDRAFT_59232 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (570 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       794  (0.0442858); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.33s 00:00:01.03 Elapsed: 00:00:00.55
# Mc/sec: 3140.41
//
Query:       EFC39647.1  [L=304]
Description: hypothetical protein NAEGRDRAFT_59233 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.015   15.5   4.0      0.015   15.5   4.0    2.7  4  PSCyt3    Protein of unknown function (DUF1588)


Domain annotation for each model (and alignments):
>> PSCyt3  Protein of unknown function (DUF1588)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       0.3   5.3e+03      40      40 ..      51      51 ..      20      85 .. 0.48
   2 ?    1.0   0.2     0.028   5.1e+02      22      64 ..     107     153 ..      92     159 .. 0.50
   3 ?   15.5   4.0   8.6e-07     0.015      17      78 ..     154     222 ..     143     227 .. 0.65
   4 ?   -2.7   0.1      0.41   7.4e+03      55      70 ..     270     286 ..     249     292 .. 0.49

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.3
      PSCyt3 40 p 40
                +
  EFC39647.1 51 T 51
                2 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.028
      PSCyt3  22 pvkRgkwvreklLcekl.ppppanv.pelkeeeeee...lttrerlea 64 
                 p  R k +r +l+ ++  +++ +n  ++ +++ + +    t+r++ +a
  EFC39647.1 107 PYLRRKSIRVDLVLKQQqEQAKKNSaKKSTKKVS-NnelETLRKEKKA 153
                 5667777777665544404444444222222222.1234577776655 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 8.6e-07
      PSCyt3  17 eeetspvkRgkwvreklLcekl.ppppanv...pelkeeeeee...lttrerleahrsaeaCasCHeli 78 
                  +e++ + +g++++ +lL ++l ++p +++   +e ++e++++     + e ++++++ ++C++CH+ i
  EFC39647.1 154 LKEENSILKGRLMQMELLFKELiRNPSTKIvknQECQTESKSTntsSCQTETIQKKQTFSECSKCHKCI 222
                 5678899******999998776155666666422223333333332345555666666677*****987 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 0.41
      PSCyt3  55 e.lttrerleahrsaea 70 
                 +   tr+++ ++ ++++
  EFC39647.1 270 NwRKTRQEFLNQIKKDK 286
                 12345555554444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3281  (0.183); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.32s 00:00:01.02 Elapsed: 00:00:00.55
# Mc/sec: 1667.27
//
Query:       EFC39648.1  [L=473]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.1e-91  308.0   0.0    1.3e-91  307.7   0.0    1.0  1  tRNA-synt_1   tRNA synthetases class I (I, L, M and V)
     0.0013   17.5   0.5      0.054   12.2   0.3    2.3  2  tRNA-synt_1g  tRNA synthetases class I (M)


Domain annotation for each model (and alignments):
>> tRNA-synt_1  tRNA synthetases class I (I, L, M and V)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  307.7   0.0   1.4e-95   1.3e-91      52     498 ..       2     465 ..       1     471 [. 0.93

  Alignments for each domain:
  == domain 1  score: 307.7 bits;  conditional E-value: 1.4e-95
  tRNA-synt_1  52 virykrmkGkevlyvpGwDhaGlaieakvekklgak..ekkerkklgreefrekvrewkaeyaeeirkqvkrlGvsvDfdreylTldkeleeavkevf 147
                  + r++ + G+  + ++ +D++Gl+ie++ ekk g+     +e ++lg ++++e++ ++  e ++e+++ ++r+G+++Df++   T +++++e+v+++f
   EFC39648.1   2 ISRFAFQFGYGLDCRFVMDCHGLPIEYEFEKKRGKLawSYSEIEELGIAKYNEECEKISIEHMDEWKNGLSRMGRWLDFSNTCSTSQPKYMENVWKIF 99 
                  678888999999*******************9887511456899****************************************************** PP

  tRNA-synt_1 148 vrladkgliyrgkklvnwstklktalselEv.eykdkkdalihvafpladkee....vklviaTTtP.eTllgdtavavnpeldyv..itkeklilae 237
                  ++l d+ liy+  kl+++s  ++++ls++E+ ++ ++++  i+++ +l  ++e    + l+     P + ll+++a++vnpe dyv  it++++il +
   EFC39648.1 100 KELWDNKLIYKDVKLLPFSIGCASPLSDIEAkNHLNVDSLEITISIELISDKEkfkgTFLMTSCMNPcWKLLANVALCVNPEKDYVkiITGKEYILSR 197
                  *******************************6667999999******976666676667777777788*******************99******976 PP

  tRNA-synt_1 238 allkslvkke.sekkiledergkeLegkevelpl.....vnrkipiiaddyvdkeaGtGvVkiaPahdedDyevgkkynl....evinildedgtlte 325
                      s ++k+ +e+ki+++++g+eL+g+++ + +     ++ +++ii      +e+GtG++++aP+   +Dy+++++       e+++++de g+   
   EFC39648.1 198 ----SYYEKHfKEEKIVDTFKGHELVGLTYVPAFeyysnNEGSFRIIPSSDPVTETGTGIIHLAPGLSLQDYNICNELRFvessELPCPIDETGKCLL 291
                  ....5677887889***********************99999*****99888889*********************999999999************* PP

  tRNA-synt_1 326 eaaefeglkvfdarkkvveelkekglllkaekiehsvpfcerskkpiiyrateqWfvrvkeladaalkavekvqfvpkskekryaswleniqdWciSR 423
                  + +efeg +v++  +++v++l+ + +llk+ek +     c+ s+  +iy+a+e Wf  +k+++ + l++ ++v++ p+   +r+ +  ++ + W iS+
   EFC39648.1 292 KGSEFEGKYVDHLSNQLVKNLTLRSMLLKKEKRTSYQNSCWISGRTLIYKAVEGWFLDMKSINTKYLENCKNVKWFPENIANRFSN--NQYEFWLISK 387
                  ************************************************************************************99..56778***** PP

  tRNA-synt_1 424 qrwWGhriplfvsketeevvvreelkelvagreeeeaekkalekeakdkl.....kkekgelekdedvlDvWFsSgswpf 498
                  +r+WG+++p+++s++ ee++v+e+++el++   + ++  +++++e++d+l      +e+  l++++ v+D WF+Sg  + 
   EFC39648.1 388 SRYWGTPLPIWMSEDGEEIIVVESIEELEK--LTGKSGLENIHREFIDHLtipspTREHVILKRVPYVFDGWFESGCFHL 465
                  *********************999999998..77777788889*******99998888899***************9875 PP

>> tRNA-synt_1g  tRNA synthetases class I (M)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.0   0.0     0.004        36      83     132 ..      78     127 ..      11     133 .. 0.79
   2 !   12.2   0.3   6.1e-06     0.054     166     239 ..     328     400 ..     316     409 .. 0.80

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.004
                   ---SEEEETTSHHHHHHHHHHHHHHHHTT-EEEEEEEEEEETTTTEEE-G CS
  tRNA-synt_1g  83 isfdkygrttseehkelvqeifkklkekgliyekeieqlycpkderflpd 132
                   + f++  +t++ +  e v +ifk+l +++liy+      ++  + + l+d
    EFC39648.1  78 LDFSNTCSTSQPKYMENVWKIFKELWDNKLIYKDVKLLPFSIGCASPLSD 127
                   56778889999999999***************998888888888777777 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 6.1e-06
                   ...........EEE.EEEEEE-GGGGHHHHHHHH.HH-TTSHHHHHHHH.HHHHT----EE-ESS-SSS-EET...T CS
  tRNA-synt_1g 166 npksaisgskpevketehlffklskfekklkewieeeekeleenvkkivkewlkegLkdlaisrdldwGipvP...g 239
                   +  + isg++ ++k  e +f++++++++k+ e   ++    +   ++i++ + +++ + + is+   wG p+P    
    EFC39648.1 328 QNSCWISGRTLIYKAVEGWFLDMKSINTKYLENC-KNV---KWFPENIANRFSNNQYEFWLISKSRYWGTPLPiwmS 400
                   568**********************999877777.343...44445677788899999**************97763 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (473 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       488  (0.0272185); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.33s 00:00:01.01 Elapsed: 00:00:00.55
# Mc/sec: 2591.62
//
Query:       EFC39649.1  [L=371]
Description: acetyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.4e-10   38.7   0.1    1.6e-09   38.0   0.1    1.4  1  Acetyltransf_1   Acetyltransferase (GNAT) family
    5.1e-07   29.8   0.0    1.3e-06   28.6   0.0    1.6  1  Acetyltransf_9   Acetyltransferase (GNAT) domain
    5.2e-07   29.5   0.0    1.2e-06   28.4   0.0    1.5  1  FR47             FR47-like protein
    9.9e-06   25.5   0.0    1.9e-05   24.6   0.0    1.4  1  Acetyltransf_10  Acetyltransferase (GNAT) domain
    3.2e-05   24.3   0.0    5.7e-05   23.5   0.0    1.4  1  Acetyltransf_7   Acetyltransferase (GNAT) domain
    0.00087   18.8   0.2     0.0018   17.8   0.2    1.6  1  Acetyltransf_15  Putative acetyl-transferase
     0.0074   16.4   0.0      0.015   15.4   0.0    1.4  1  Acetyltransf_CG  GCN5-related N-acetyl-transferase
  ------ inclusion threshold ------
      0.011   16.5   0.0      0.019   15.6   0.0    1.5  1  Acetyltransf_3   Acetyltransferase (GNAT) domain


Domain annotation for each model (and alignments):
>> Acetyltransf_1  Acetyltransferase (GNAT) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.0   0.1   7.2e-13   1.6e-09      34     117 .]     265     352 ..     226     352 .. 0.88

  Alignments for each domain:
  == domain 1  score: 38.0 bits;  conditional E-value: 7.2e-13
                     EEEEEEETTEEEEEEEEEEEET.......TSTTEEEEEEEEESGGGTTSSHHHHHHHHHHHHHHHTTESEEEEEEETTEHHHHHHHHHTTE CS
  Acetyltransf_1  34 gllvaeedgeliGfisllkipd.......ekggvayieslaVspeyrgkGlGsaLlealeerareegikkivlaveedndaairlYeklGF 117
                      +++++e++e++   ++l  ++       e+ ++a+i+s+a + ++rg+G++++ + +l+e a+ +g++ + l+ +e+    ++lY klGF
      EFC39649.1 265 DYVIILENNEIASAGMILYGNEleskdykENSNCAAIYSIATRDQFRGRGYATMIVVTLMELAKLRGYDHVILHASESG---CNLYSKLGF 352
                     56679999**99999999999999*****99*************************************99999888887...****99**9 PP

>> Acetyltransf_9  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.6   0.0   5.6e-10   1.3e-06      41     126 ..     263     353 ..     234     354 .. 0.83

  Alignments for each domain:
  == domain 1  score: 28.6 bits;  conditional E-value: 5.6e-10
                     TSEEEEEEETTEEEEEEEE...EEEEEEETTEEEEEEEEEEEEE-CCGTTS-HHHHHHHHHHHHHHHTT--EEEE--SS..HHHHHTTT-E CS
  Acetyltransf_9  41 esrvlgaedngelvgqlal...lplelnvpGktlkaagvtgVavapehrgrgvlskLlaraleemreegqplsllfPss..ipiYrrfGye 126
                      s+++++ +n+e+++  ++   + le + + ++ ++a+++++a+  + rgrg+++ ++ +++e ++ +g+  ++l++s+   ++Y ++G+e
      EFC39649.1 263 LSDYVIILENNEIASAGMIlygNELESKDYKENSNCAAIYSIATRDQFRGRGYATMIVVTLMELAKLRGYDHVILHASEsgCNLYSKLGFE 353
                     47899999999999986652224677777779*********************************************773369*******8 PP

>> FR47  FR47-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.4   0.0   5.4e-10   1.2e-06      20      80 ..     297     355 ..     290     360 .. 0.85

  Alignments for each domain:
  == domain 1  score: 28.4 bits;  conditional E-value: 5.4e-10
                 TTSSEEEEEE-GGG-SSSHHHHHHHHHHHHHHHS-S-EEEEEETT-HHHHHHHHHHT-EEE CS
        FR47  20 dggelgalqvlpehrrrGlgsrlvkalakeiaergktvllvvvasNtpsirlyeklGfeki 80 
                 +  +++++ +++++r+rG+++ +v  l +    rg++ +++   + +  ++ly+klGfek 
  EFC39649.1 297 NCAAIYSIATRDQFRGRGYATMIVVTLMELAKLRGYDHVILH--ASESGCNLYSKLGFEKK 355
                 55789**********************987777**9987664..44678*********986 PP

>> Acetyltransf_10  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.6   0.0   8.6e-09   1.9e-05      52     108 ..     296     354 ..     256     362 .. 0.84

  Alignments for each domain:
  == domain 1  score: 24.6 bits;  conditional E-value: 8.6e-09
  Acetyltransf_10  52 s...hisllfVdpeyrgqGigkaLleaveeeaekdgikleltvnaspyavpfYeklGFka 108
                      s    i+ ++ ++++rg+G++++++ ++ e a+ +g+  ++ ++as    ++Y klGF++
       EFC39649.1 296 SncaAIYSIATRDQFRGRGYATMIVVTLMELAKLRGYD-HVILHASESGCNLYSKLGFEK 354
                      1566999****************************999.*******************97 PP

>> Acetyltransf_7  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   2.5e-08   5.7e-05      12      76 .]     273     354 ..     262     354 .. 0.59

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 2.5e-08
                     TEEE..EEEEEEEES...........TCTEEEEE-GGGTTSSHHHHHHHH....TT.SEEEEEEEEETHH.HHHHHHHHTTEEE CS
  Acetyltransf_7  12 gkiv..Gfialslld...........aeitrlaVdpeyrgkGiGraLlea....ae.kgiileqlelnae.kaikfYeklGFee 76 
                     ++i   G+i +  +            a i  +a++ ++rg+G+++ ++      a+ +g+   ++ l+a+    ++Y klGFe+
      EFC39649.1 273 NEIAsaGMILYGNELeskdykensncAAIYSIATRDQFRGRGYATMIVVTlmelAKlRGYD--HVILHASeSGCNLYSKLGFEK 354
                     3333334444333336666655555445555****************86333332256733..334422225688*******95 PP

>> Acetyltransf_15  Putative acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.2   7.9e-07    0.0018      62     137 ..     289     353 ..     184     356 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 7.9e-07
  Acetyltransf_15  62 lvssilieknvleiYtlyvsekyrgkGlakklLeeslkelkknYkvdnelllaLHlnpkDksMnisfalYyslgFr 137
                      +   + +++n   iY++ + +++rg+G+a +++    +el    k++  + ++LH +++         lY++lgF 
       EFC39649.1 289 SK-DYKENSNCAAIYSIATRDQFRGRGYATMIVVTL-MELA---KLRGYDHVILHASES------GCNLYSKLGFE 353
                      33.478899999*****************9988766.5554...566666888888865......45566666665 PP

>> Acetyltransf_CG  GCN5-related N-acetyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   6.7e-06     0.015      16      58 ..     291     332 ..     274     338 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 6.7e-06
  Acetyltransf_CG  16 eYevrkegvldfthTeVpeelrGkGiAkkLvkaalddareegl 58 
                      +Y+ ++++  +++ + + +++rG+G+A  +v + ++ a+ +g+
       EFC39649.1 291 DYK-ENSNCAAIYSIATRDQFRGRGYATMIVVTLMELAKLRGY 332
                      788.8889****************************9998876 PP

>> Acetyltransf_3  Acetyltransferase (GNAT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.6   0.0   8.5e-06     0.019      54     122 ..     264     340 ..     211     353 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 8.5e-06
  Acetyltransf_3  54 ygwaivlkdtgviGsvglrdleeedee........aelgymla.ps.fwgkGyateavralleyafeelglerlvavid 122
                       ++i+l+++ +i s+g+  + +e e+        +   y +a ++ f+g+Gyat  v  l+e+a +  g+++++ +++
      EFC39649.1 264 SDYVIILENN-EIASAGMILYGNELESkdykensnCAAIYSIAtRDqFRGRGYATMIVVTLMELA-KLRGYDHVILHAS 340
                     3388877666.788888888888887788999999777777777778******************.6777777766554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       620  (0.0345808); expected 358.6 (0.02)
Passed bias filter:                      373  (0.0208043); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.53
# Mc/sec: 2109.16
//
Query:       EFC39650.1  [L=154]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      6e-34  115.6   1.2    8.6e-34  115.1   0.7    1.5  2  ubiquitin      Ubiquitin family
    1.4e-19   69.9   5.9    1.4e-19   69.9   5.9    1.8  2  Ribosomal_S27  Ribosomal protein S27a
    1.2e-16   60.3   0.7    1.8e-16   59.7   0.7    1.3  1  Rad60-SLD      Ubiquitin-2 like Rad60 SUMO-like
    2.3e-05   24.7   0.2      9e-05   22.9   0.2    1.8  1  Ubiquitin_2    Ubiquitin-like domain
    2.9e-05   24.1   1.3    0.00019   21.5   1.0    2.2  2  Rad60-SLD_2    Ubiquitin-2 like Rad60 SUMO-like
     0.0032   17.4   0.1     0.0049   16.8   0.1    1.3  1  TBK1_ULD       TANK binding kinase 1 ubiquitin-like domain
     0.0033   17.7   1.7     0.0035   17.6   0.2    1.8  2  Ubiquitin_5    Ubiquitin-like domain
     0.0038   17.7   0.8     0.0053   17.3   0.8    1.2  1  DUF2407        DUF2407 ubiquitin-like domain
     0.0041   17.1   2.9        1.8    8.7   0.2    2.9  3  Ubiquitin_4    Ubiquitin-like domain
     0.0082   16.0   0.0      0.012   15.4   0.0    1.3  1  Sde2_N_Ubi     Silencing defective 2 N-terminal ubiquitin dom


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.1   0.7   4.8e-37   8.6e-34       1      72 []       3      74 ..       3      74 .. 0.99
   2 ?   -3.3   0.0       4.5     8e+03      56      70 ..     108     122 ..     107     123 .. 0.72

  Alignments for each domain:
  == domain 1  score: 115.1 bits;  conditional E-value: 4.8e-37
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC39650.1  3 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 74
                9********************************************************************986 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 4.5
                 GHTTSTTEEEEEEES CS
   ubiquitin  56 eygiqdgstlhlvlr 70 
                 +y ++++ +++++ r
  EFC39650.1 108 YYEVTNDGKVVCNRR 122
                 688888888887765 PP

>> Ribosomal_S27  Ribosomal protein S27a
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   0.1       4.8   8.6e+03       6      17 ..      16      27 ..      16      29 .. 0.78
   2 !   69.9   5.9   8.1e-23   1.4e-19       3      44 ..     107     147 ..     106     148 .. 0.97

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 4.8
                   CESSSSSEEESS CS
  Ribosomal_S27  6 kvddsgkverlr 17
                   +v++++++e  +
     EFC39650.1 16 EVESNDTIENVK 27
                   588999999876 PP

  == domain 2  score: 69.9 bits;  conditional E-value: 8.1e-23
                    SSCCESSSSSEEESS-B-SS-S-TTSBEEECTTEEEESSTTT CS
  Ribosomal_S27   3 kyYkvddsgkverlrkeCpreCGaGvfMAehkdRkyCGkCgl 44 
                    kyY+v ++gkv + r+ Cp+ CG+Gv MA h+dR+yCGkC+l
     EFC39650.1 107 KYYEVTNDGKVVCNRRTCPK-CGPGVLMAAHEDRQYCGKCHL 147
                    9*******************.********************7 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.7   0.7   9.9e-20   1.8e-16       1      72 []       1      71 [.       1      71 [. 0.98

  Alignments for each domain:
  == domain 1  score: 59.7 bits;  conditional E-value: 9.9e-20
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC39650.1  1 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 71
                89************************************.******************************986 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.2     5e-08     9e-05      16      80 ..      13      69 ..       2      70 .. 0.86

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 5e-08
                 EEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2 16 serrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80
                  +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC39650.1 13 ITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 69
                 55667899************************99........5667899*********9999995 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   1.0   1.1e-07   0.00019      12     103 ..      10      87 ..       1     100 [. 0.72
   2 ?    0.4   0.0      0.38   6.9e+02      46      70 ..     104     128 ..      94     147 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 1.1e-07
                  S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE---SS----.XXXXXX CS
  Rad60-SLD_2  12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvvrenlsekksekkakka 103
                  G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+r    +kk+ kk++ +
   EFC39650.1  10 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVLRLRGGKKKKRKKKNFK 87 
                  66.6667788889999999998.....5566644..34559*****************54433......57*****9988888777774432 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.38
                  -SCCCEEEEETTEEE-TTSBCCCCS CS
  Rad60-SLD_2  46 ksvndlklilaGkiLennktlkelr 70 
                   + ++  + ++Gk+  n +t  +++
   EFC39650.1 104 IEKKYYEVTNDGKVVCNRRTCPKCG 128
                  56677788999**999999988885 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   2.7e-06    0.0049      19      53 ..      17      51 ..       4      71 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 2.7e-06
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53
                +++++t++++  +++++  i++++Q l+f g++l 
  EFC39650.1 17 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 51
                6899****************************973 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.2     2e-06    0.0035      32      93 ..      11      73 ..       4      78 .. 0.85
   2 ?    1.1   0.5      0.28     5e+02      14      35 ..      65      86 ..      62     123 .. 0.74

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 2e-06
  Ubiquitin_5 32 kkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93
                 k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+l
   EFC39650.1 11 KTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLRL 73
                 55678888888999999**********************************999875477776 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.28
  Ubiquitin_5 14 AtlellLprdkrketkeekkkl 35
                  tl+l+L  +  k++k++kk++
   EFC39650.1 65 STLHLVLRLRGGKKKKRKKKNF 86
                 5788888877777556545543 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.8     3e-06    0.0053      14      80 ..      13      85 ..       6     108 .. 0.69

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3e-06
     DUF2407 14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslasslklpees..........vsdkaeksk 80
                ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++   ++e++          +++k++k++
  EFC39650.1 13 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTlhlvlrlrggKKKKRKKKN 85
                566666..6789999999999987..67777789**************98655554545887776654222222222 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.2   0.00099       1.8       1      32 [.       1      32 [.       1      36 [. 0.94
   2 !    6.4   0.0    0.0051       9.1      58      86 ..      43      70 ..      39      73 .. 0.84
   3 ?    1.1   0.0      0.23   4.2e+02      30      75 ..      82     127 ..      77     129 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00099
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32
                 +++ vk l g+++ ++v++n t++++k  i+ 
   EFC39650.1  1 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 32
                 7899*************************997 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0051
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L+f g++L+ d  +l++y i+++s+l+ v
   EFC39650.1 43 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 70
                 889999986.6789************976 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.23
  Ubiquitin_4  30 ierkvelklkrekekkkisWkyvWktycLsfegekLkddkaklkey 75 
                   +++++  +k+++++k++    + k+y+ + ++ k+ +++ +  ++
   EFC39650.1  82 KKKNFKSPKKAAHKHKNVPLLPIEKKYYEVTNDGKVVCNRRTCPKC 127
                  5678888899999999999999999999999999999988876665 PP

>> Sde2_N_Ubi  Silencing defective 2 N-terminal ubiquitin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   6.9e-06     0.012       2      89 ..       2      77 ..       1      79 [. 0.85

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 6.9e-06
  Sde2_N_Ubi  2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGGK 89
                +++v+++ g+    t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGGK
  EFC39650.1  2 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGGK 77
                8999*99996....999*****************998877555.45555554.66..99999****999999....9**********9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1323  (0.0737911); expected 358.6 (0.02)
Passed bias filter:                      704  (0.039266); expected 358.6 (0.02)
Passed Vit filter:                        85  (0.00474092); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.53
# Mc/sec: 869.11
//
Query:       EFC39651.1  [L=486]
Description: predicted protein, partial [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-50  173.6  11.7    1.9e-36  127.0  10.5    2.2  2  TFIIA        Transcription factor IIA, alpha/beta subunit
  ------ inclusion threshold ------
        1.3    8.8   7.5        2.4    8.0   7.5    1.3  1  Sigma70_ner  Sigma-70, non-essential region
        2.5    6.2  13.7        3.5    5.7  13.7    1.1  1  Nop14        Nop14-like family
        2.6    7.5  11.8        0.5    9.9   6.8    1.9  2  PPP4R2       PPP4R2
        3.4    5.8  11.2        5.2    5.2  11.2    1.2  1  CDC45        CDC45-like protein
        5.2    5.0  19.7        7.4    4.5  19.7    1.1  1  DNA_pol_phi  DNA polymerase phi


Domain annotation for each model (and alignments):
>> TFIIA  Transcription factor IIA, alpha/beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.8   0.0   2.8e-15   8.4e-12       2      98 ..      15     116 ..      14     154 .. 0.65
   2 !  127.0  10.5   6.3e-40   1.9e-36     306     415 .]     380     486 .]     344     486 .] 0.83

  Alignments for each domain:
  == domain 1  score: 45.8 bits;  conditional E-value: 2.8e-15
       TFIIA   2 YrsvIedVIesvredFeeeGvdeqvLeeLkqlWesKllqskaaefpwdpkpeeaqspqfvlqlpqslkqalq.asaaaa.....sqapastsqslpslv 94 
                 Yrs I++V ++++e F eeG ++ v++eLk+lW  K+ +s+a+   w+  p ++ s      +++s ++a + +++aaa      + ++s++  ++s +
  EFC39651.1  15 YRSLIDEVAAGIQEIFVEEGYNSDVINELKKLWGDKIGESGAVP-AWNITPGQSSSRGSNRGAAASRNAARSrNQNAAAsssntAIPTQSSQLGTQSTQ 112
                 ********************************************.9*8888886666555554444444433222222212222222222222222222 PP

       TFIIA  95 ipag 98 
                 i+++
  EFC39651.1 113 INQS 116
                 2222 PP

  == domain 2  score: 127.0 bits;  conditional E-value: 6.3e-40
       TFIIA 306 sladlseilqlDGagddsdeeeeeeesdedsdsessddedeqveEDplNSdDDvddeddddlfdtdnvivCqYDKvhRsKNKWKftLKDGvmtvnGkdY 404
                  +++ ++  q+DGa+dd+de++e+++s+ed+++e+  +++  + E+ l SdDDv+d++d+d   t n+i+ qY+Kv+R+KN+WK+tLK G+m+++GkdY
  EFC39651.1 380 GNNNNPNFRQYDGANDDDDEDDEDDDSEEDEEEEEPSKSAASTGEEELGSDDDVEDDKDPD---TPNIILAQYEKVTRHKNRWKCTLKCGIMHLDGKDY 475
                 333788999***********888888877766555555566699************99999...*********************************** PP

       TFIIA 405 VFsKAiGeaEW 415
                 +F+K +G++EW
  EFC39651.1 476 LFNKLTGDFEW 486
                 *********** PP

>> Sigma70_ner  Sigma-70, non-essential region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.0   7.5   0.00081       2.4      27      84 ..     391     456 ..     375     470 .. 0.56

  Alignments for each domain:
  == domain 1  score: 8.0 bits;  conditional E-value: 0.00081
  Sigma70_ner  27 dGflDeeeeeeeeeeeedeeeeeee..........eddd..eeeseseaadeeelkeealekfeelreqy 84 
                  dG +D++  +e++e++++ee+eeee          e  +  +++++ e+++    ++ +l+++e++  + 
   EFC39651.1 391 DGANDDD--DEDDEDDDSEEDEEEEepsksaastgE--EelGSDDDVEDDKDPDTPNIILAQYEKVTRHK 456
                  5666622..222222222222222223344555422..13455555555555556666777777776665 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7  13.7    0.0012       3.5     348     409 ..     380     440 ..     354     464 .. 0.40

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0012
       Nop14 348 eeededdfeedddlveseseeeeeeeeedeeeeedeeeeeeeeededdlsdleseeeeeede 409
                 +++++ +f + d ++++++e++e +++++e+eee+e +++ +++ e++l ++++ e++++ +
  EFC39651.1 380 GNNNNPNFRQYDGANDDDDEDDE-DDDSEEDEEEEEPSKSAASTGEEELGSDDDVEDDKDPD 440
                 44444444444422222222221.11111111111111112222222222222222222222 PP

>> PPP4R2  PPP4R2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.2      0.19   5.5e+02     166     206 ..      78     118 ..      32     125 .. 0.67
   2 ?    9.9   6.8   0.00017       0.5     190     261 ..     362     436 ..     327     453 .. 0.54

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.19
      PPP4R2 166 keedkansssqedsedvslvsipwvdekteselspfikeid 206
                  +++ a s +q+    +s + ip+  ++ ++++++ ++  d
  EFC39651.1  78 ASRNAARSRNQNAAASSSNTAIPTQSSQLGTQSTQINQSQD 118
                 34444556666667777777777766666666666655544 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00017
      PPP4R2 190 vdekteselspfikeidsimsvnlgfedeeekeedd...neseesaseseeiteekdesvkveekdddeeddeed 261
                 +d ++  +l+p +++    ++ n++f + +  ++dd   +e+++s++++ee+  +k+  ++ ee+  +++d e+d
  EFC39651.1 362 LDTNKRLRLDPNSNDARLGNNNNPNFRQYDGANDDDdedDEDDDSEEDEEEEEPSKSAASTGEEELGSDDDVEDD 436
                 455555566666666555555555555544444433322222222222222222233333333322233333333 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2  11.2    0.0017       5.2     136     183 ..     391     439 ..     364     466 .. 0.41

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0017
       CDC45 136 deeeeeeddddeeeeeeeeedeedeeedeeeskkkrk.sksdeeeesdd 183
                 d  ++++d+dde++++ee+e+ee+ +++  ++++++  s++d e+++d 
  EFC39651.1 391 DGANDDDDEDDEDDDSEEDEEEEEPSKSAASTGEEELgSDDDVEDDKDP 439
                 2222323333233333322222222222222222332233333332222 PP

>> DNA_pol_phi  DNA polymerase phi
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5  19.7    0.0025       7.4     639     684 ..     395     440 ..     378     458 .. 0.49

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.0025
  DNA_pol_phi 639 edededeeddeeeeeeddeededseedddeeesdedeededdedvd 684
                  +d+ded+edd++ee+e++ee ++s  +  eee  +d++ edd+d d
   EFC39651.1 395 DDDDEDDEDDDSEEDEEEEEPSKSAASTGEEELGSDDDVEDDKDPD 440
                  3334444444444444444444444444444445555544444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (486 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1031  (0.0575046); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                       104  (0.00580066); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.75u 0.36s 00:00:01.10 Elapsed: 00:00:00.54
# Mc/sec: 2697.85
//
Query:       EFC39652.1  [L=420]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.054   13.4   0.5       0.16   11.9   0.2    1.9  2  VapB_antitoxin  Bacterial antitoxin of type II TA system, Vap
      0.062   13.5   0.2        4.5    7.5   0.1    3.2  3  Sep15_SelM      Sep15/SelM redox domain


Domain annotation for each model (and alignments):
>> VapB_antitoxin  Bacterial antitoxin of type II TA system, VapB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0      0.97   8.7e+03      32      41 ..     197     206 ..     197     209 .. 0.79
   2 ?   11.9   0.2   1.8e-05      0.16      24      42 ..     350     370 ..     347     377 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 0.97
                     XXX------- CS
  VapB_antitoxin  32 LreLiqrrkr 41 
                     L+e+i r++ 
      EFC39652.1 197 LKEFITRPEI 206
                     899**99875 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 1.8e-05
                     XXXXXXXXXXX------..-H CS
  VapB_antitoxin  24 KrEaVnlALreLiqrrk..re 42 
                     ++E+Vn A++ L+qr+k  ++
      EFC39652.1 350 QKELVNIAIKKLLQREKdfSK 370
                     79**************97744 PP

>> Sep15_SelM  Sep15/SelM redox domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.32   2.9e+03      15      40 ..      32      57 ..      28      58 .. 0.83
   2 ?    1.6   0.0     0.036   3.2e+02      18      50 ..     198     227 ..     190     232 .. 0.82
   3 ?    7.5   0.1    0.0005       4.5      15      39 ..     270     294 ..     264     296 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.32
                HHHHHHTTTHH.HHBTTEEEEEESS- CS
  Sep15_SelM 15 pevkaFvkedaaakfpnlevkyvrga 40
                 ++  F+ ++ ++   +l +++v+++
  EFC39652.1 32 QQISGFICKKDGPFGGSLVITHVNNQ 57
                5789999999989999******9976 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.036
                 HHHTTTHH.HHBTTEEEEEESS---EEEEE-SS CS
  Sep15_SelM  18 kaFvkedaaakfpnlevkyvrgapPkLillded 50 
                 k+F++       ++l  +    + P L+l+d d
  EFC39652.1 198 KEFITRPE---IQSLSCELCGKKEPHLVLYDFD 227
                 77777666...8999999999*********965 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0005
                 HHHHHHTTTHH.HHBTTEEEEEESS CS
  Sep15_SelM  15 pevkaFvkedaaakfpnlevkyvrg 39 
                 ++v+ F+k++   k +nlev+y  +
  EFC39652.1 270 RQVADFIKNEEYRKMNNLEVRYEYN 294
                 69*******************9865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (420 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1165  (0.0649785); expected 358.6 (0.02)
Passed bias filter:                      478  (0.0266607); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.50
# Mc/sec: 2505.32
//
Query:       EFC39653.1  [L=820]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.5e-05   24.9   2.7      4e-05   23.5   2.7    1.7  1  dCache_1       Cache domain
    3.7e-05   23.4   0.2     0.0023   17.6   0.1    2.4  2  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
  ------ inclusion threshold ------
      0.054   13.3   0.1       0.15   11.8   0.1    1.7  1  ATP_bind_1     Conserved hypothetical ATP binding protein
      0.067   12.8   0.5       0.19   11.3   0.5    1.8  1  Baculo_11_kDa  Baculovirus 11 kDa family
       0.77    9.8   3.0       0.39   10.8   0.2    1.8  2  RP-C_C         Replication protein C C-terminal region


Domain annotation for each model (and alignments):
>> dCache_1  Cache domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   2.7   1.1e-08     4e-05       6     207 ..      78     316 ..      76     368 .. 0.59

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 1.1e-08
    dCache_1   6 qaeeqllglaeqlanniedvlds....lenlaetlasnpslqdlleepnraneasreslqallksilksn........................pdis. 75 
                 +a eq++ l++ + ++i+++++     ++++a  la + +  ++            + ++  l+ ++++                         +  + 
  EFC39653.1  78 AALEQVDVLITNMNEKIQAFMNGqlipAKYIADSLADDYH--NYHI----------DFADTVLTYLYQRIktfgvtvtnfclgeqgnnalyafsA--Dv 162
                 5667777777777777777777744444455555555422..2222..........222222222211111112222222222222222222221..01 PP

    dCache_1  76 ..............gvylvdadGqv.iassdpssppnleg.....tddpadrdwykealaggg..gkpvisdpyvdqtggkpvitiavpiyd....dsg 148
                               ++ ++ a+ +  ++  +p+            t+ + ++d+y e ++  +   +  ++ py   + g   ++ ++piy+    +sg
  EFC39653.1 163 ktkslalamkrqkgNFVVYAANMTTgLY--NPN------SystniTYAVGKTDYYLESIELMKmyPDGAFGAPYKVIN-GPQSTYWSTPIYNrtelPSG 252
                 1111111111122122222233332343..333......0333449*************9998887777888896566.999*********96555444 PP

    dCache_1 149 ..kfiGvlaadldldnlqdllsniklgetgyvfivd.sdGniiahpd..kdllgknlrdelkaq 207
                   + iG + ++++ld + ++ls ik+ e+gyv + + +++ ii ++   +d + k+++ ++  +
  EFC39653.1 253 kkNRIGFAKINISLDAIAQFLSAIKVLEKGYVILSEyGNDYIIGSSLtiPDIVLKRMKATNVTT 316
                 5577********************************6666666665577888877777776544 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0     0.015        52      45     116 ..     305     402 ..     297     411 .. 0.79
   2 !   17.6   0.1   6.3e-07    0.0023       6     169 ..     532     697 ..     530     711 .. 0.83

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.015
  Guanylate_cyc  45 lldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmleal.eevavesk.........................eglkvrvGihtGpvvag 114
                    +l++ k ++v t G   +++  l+++k +++++  ++ L +++++ e++ v+s+                          +  v +G++ G +++g
     EFC39653.1 305 VLKRMKATNVTTRGAGTLMTKLLQHQKDNNLNETTDIRLTLTNDAgESFLVSSSpyiffnlkwrmtlvfderevkngiiMSSYVIIGVSIGVCLLG 400
                    5667777777788877777777777888888888888888888887788888767788888888888888888886666666788*********** PP

  Guanylate_cyc 115 vi 116
                    vi
     EFC39653.1 401 VI 402
                    *9 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 6.3e-07
  Guanylate_cyc   6 ydevtilFadIvgftalssahspievvklLnelyarfdelldekk.vykvktiGdaymvvsglpeekaahaaklaelaLdmleal.eevaveskeg 99 
                    ++e++i++  +++ ++ s + +  ++ +l+ +  +++ ++++  k   ++k   + y++++  ++++aa++++ +++ L +l++l e+ +++++++
     EFC39653.1 532 MKECAIIYLTVPNLNEDSYEFESGMLSNLISKALTSISTICKTSKaDLQIKSY-NEYVITFTDKNPQAAALETSLKI-LTLLNSLnETLSKDNQPK 625
                    67889999999999999999999999****************99966788887.88999999998888888777776.899999989999999*** PP

  Guanylate_cyc 100 lkvrvGihtGpvvagviG.akkprydvwGntvnlAsrmestgkagkiqv..seetyellkeeqfeltergeve 169
                    +k+     +G  ++g +G ++++ + ++G  +n A  ++  ++  +i +    + y+  k ++f ++ ++++ 
     EFC39653.1 626 IKMCASGASGNGIMGNVGsKQMRFFAMIGSVINRAKELNEFSNFLDIPIvcDWSSYKFTK-QSFIFRPVERIF 697
                    ******************66777789*****************99999933234444444.777777777666 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.1   4.2e-05      0.15     123     220 ..     534     630 ..     516     640 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 4.2e-05
  ATP_bind_1 123 alvvvyLvDsqrltdptkfisgllsalsamlrlelPhvvvlnkfDllkek.lekeleffedvealslllekeeekykklaeaiaelleefalvlrflpl 220
                 +  ++yL  ++  +d+ +f sg+ls l   + +++ ++   +k+Dl  ++ +e+ + f     +  +l+++   k  +l +++ e+l++ +     +++
  EFC39653.1 534 ECAIIYLTVPNLNEDSYEFESGMLSNLISKALTSISTICKTSKADLQIKSyNEYVITFTDKNPQAAALETS--LKILTLLNSLNETLSKDNQPKIKMCA 630
                 445689999999999*******************************7766677777776655555555444..46777888888888877777444444 PP

>> Baculo_11_kDa  Baculovirus 11 kDa family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.5   5.4e-05      0.19      27      80 ..      35      89 ..      22      93 .. 0.64

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5.4e-05
  Baculo_11_kDa 27 srNrsflrdFvLvicglvvfvvivlfilLlvvi.lknaeaeeaekekrektllaN 80
                   + Nr fl  F+L i  ++++ ++++ ++  + i +    ++ea+  +    l+ N
     EFC39653.1 35 NSNRNFLLKFILSIRLFLIIAIVLIVLMTAIPIwSAAYTMNEAAALEQVDVLITN 89
                   67************98877644443333333330333444455555555555555 PP

>> RP-C_C  Replication protein C C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.2   0.00011      0.39      22     114 ..     447     538 ..     440     547 .. 0.75
   2 ?   -2.3   0.3       1.1   3.9e+03      36      70 ..     752     785 ..     731     798 .. 0.58

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00011
      RP-C_C  22 laeleelleelealreevenalesalkaenssanesqnerhiqnsnpdsssesepasekereekeaaaasaeaepsekksvplglvlkacPei 114
                 +++l+e +++l ++r+ + + + ++l+ ++ ++++ ++++ ++n  +  +s +e++s+ + ++ ++++ s++++   ++ ++lgl +k c  i
  EFC39653.1 447 YSSLTETVRWLGEIRAFIPDSVLNQLEMTKLETEDDKQDNNHHNAYESFHSRKESRSHMSHSSGNHSKISKKEN-IANNLFKLGLSMKECAII 538
                 67899***************999999999999998866666666666455555556666665555555555554.567889999999999755 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1.1
      RP-C_C  36 reevenalesalkaenssanesqnerhiqnsnpds 70 
                 +e+v+n+l s+l++++ss+ e +  ++ ++  ++s
  EFC39653.1 752 QEQVDNIL-SHLSSHKSSGVEDKVVERLEHLLTKS 785
                 56667776.55666666655553333333222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (820 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1544  (0.0861175); expected 358.6 (0.02)
Passed bias filter:                      685  (0.0382063); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.81u 0.36s 00:00:01.17 Elapsed: 00:00:00.54
# Mc/sec: 4601.69
//
Query:       EFC39654.1  [L=134]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0012   19.2   1.6     0.0019   18.5   1.6    1.3  1  LPAM_1    Prokaryotic membrane lipoprotein lipid attachment s
  ------ inclusion threshold ------
       0.13   12.7   0.5       0.23   11.9   0.5    1.3  1  YvfG      YvfG protein


Domain annotation for each model (and alignments):
>> LPAM_1  Prokaryotic membrane lipoprotein lipid attachment site
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.5   1.6   2.2e-07    0.0019       1      17 [.       1      17 [.       1      17 [. 0.99

  Alignments for each domain:
  == domain 1  score: 18.5 bits;  conditional E-value: 2.2e-07
      LPAM_1  1 MKKillalgalllLsGC 17
                M K++ al+a+llL++C
  EFC39654.1  1 MNKFITALVATLLLAAC 17
                9**************** PP

>> YvfG  YvfG protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.5   2.5e-05      0.23      11      35 ..      47      72 ..      44      80 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 2.5e-05
                HHHHHHHC-SS.S-CCHHHHHH.HHH CS
        YvfG 11 nlkeyieqneayedkiqalnaY.Ykv 35
                n+ +y +  ++y ++i+a+n+  Y +
  EFC39654.1 47 NYNQYAQNTQSYLNQINAVNSNpYSS 72
                999*****************953555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (134 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       541  (0.0301746); expected 358.6 (0.02)
Passed bias filter:                      278  (0.0155056); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.43u 0.30s 00:00:00.73 Elapsed: 00:00:00.46
# Mc/sec: 869.87
//
Query:       EFC39655.1  [L=165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1044  (0.0582297); expected 358.6 (0.02)
Passed bias filter:                      534  (0.0297841); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.46u 0.25s 00:00:00.71 Elapsed: 00:00:00.44
# Mc/sec: 1138.94
//
Query:       EFC39656.1  [L=195]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.065   13.2   1.1       0.28   11.2   0.0    2.4  2  RAMP             Receptor activity modifying family
       0.24    9.5   6.3      0.029   12.6   2.5    1.3  2  Glucan_synthase  1,3-beta-glucan synthase component
        6.6    6.7  15.5        9.6    6.1  15.5    1.2  1  DUF5090          Domain of unknown function (DUF5090)
        8.7    5.6  15.6         13    5.1  15.6    1.3  1  TssN             Type VI secretion system, TssN


Domain annotation for each model (and alignments):
>> RAMP  Receptor activity modifying family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   6.3e-05      0.28      38     100 ..      15      77 ..       2      84 .. 0.74
   2 ?   -0.6   0.6      0.29   1.3e+03      88     108 ..     157     177 ..     136     179 .. 0.49

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 6.3e-05
        RAMP  38 ekvaeklgcfwPnklveeffleiHkkyFsncsleeealedppeeillalilvpillilllval 100
                  + +  +   +P+++ e+++++ H++  +  ++++  l++  +e ++   lv ++lill+v+l
  EFC39656.1  15 DQSQGGMAAHYPQSQLEDLLIQQHESESKAEKVKRILLTNILTERIIQTCLVVVMLILLVVYL 77 
                 5666678899**************998887777777776666666666666666666665555 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.29
        RAMP  88 lvpillilllvalvvwkskrs 108
                 ++  l+ l+l  ++v k krs
  EFC39656.1 157 MTLELFSLVLSIVMVIKKKRS 177
                 222233344444555666665 PP

>> Glucan_synthase  1,3-beta-glucan synthase component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   2.5   6.5e-06     0.029     732     814 ..      37     121 ..      21     128 .. 0.82
   2 ?   -3.7   0.1      0.53   2.4e+03     187     191 ..     159     163 ..     135     186 .. 0.50

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 6.5e-06
  Glucan_synthase 732 geesekeskdvkrasllnlllseiilellvvl..llliaylfinsqtgvkeaeatnsvlrlaivsllpillnvvvllvlfalsll 814
                      ++ese+++++vkr  l+n+l++ ii ++lvv+  +ll+ ylf+ s ++ +   +   +++l++ +l +i++++   ++l+ +  +
       EFC39656.1  37 QHESESKAEKVKRILLTNILTERIIQTCLVVVmlILLVVYLFLGSVEEKAFIGTIALLIKLVLSALSVIICSFGNYFILIGVCAI 121
                      56788888999***********99998766551156789*******99999999999*************999888888776544 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 0.53
  Glucan_synthase 187 erKfk 191
                       + f 
       EFC39656.1 159 LELFS 163
                      11111 PP

>> DUF5090  Domain of unknown function (DUF5090)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1  15.5    0.0021       9.6      45     177 ..      52     180 ..      41     190 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0021
     DUF5090  45 vknlklkdiikitlllkavllipiyllviaengnkldflksksriifltlikivlsilvdlvvyfselsslfkvflllkiikllitlivllalsistgl 143
                 + n+ ++ ii   l++ +++l+ +yl+ +  +   + f+  +  +i l+l  ++  i+ ++  yf  ++  +  f+ + +    ++++++++ + +   
  EFC39656.1  52 LTNILTERIIQTCLVVVMLILLVVYLFLGSVEE--KAFIGTIALLIKLVL-SALSVIICSFGNYFILIGVCAIQFVSILVGD-SLLFLIMFFPNER-VF 145
                 5799999*********************55555..479999999999988.4466677777777777777776666655554.4555555555555.57 PP

     DUF5090 144 filvlsliylllcl.iidllflyYlaiylkrlesd 177
                  + vl+ iy ++ l +++l++   + i+ kr e+ 
  EFC39656.1 146 DTAVLIPIYSMMTLeLFSLVLSIVMVIKKKRSETK 180
                 78899999998887356666666677788887774 PP

>> TssN  Type VI secretion system, TssN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1  15.6    0.0029        13      10     114 ..      65     170 ..      55     187 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0029
        TssN  10 lavilllilsliakknkllkkkkliiyi.Llaglvlalpgllgf.lknefvpygyillqilylllGilhlylllkkffkelkekk.ilfeilltlivil 105
                 l+v++l il+++      +++k +i +i Ll+ lvl+ ++++   ++n f+++g  ++q++++l+G   l+ l+  f +e   ++ +l+ i  +++  l
  EFC39656.1  65 LVVVML-ILLVVYLFLGSVEEKAFIGTIaLLIKLVLSALSVIICsFGNYFILIGVCAIQFVSILVGDSLLF-LIMFFPNERVFDTaVLIPIYSMMTLEL 161
                 333333.33333333456788888866536677888777777776***********************999.888888777777756666666666666 PP

        TssN 106 lglvlfvlv 114
                 ++lvl +++
  EFC39656.1 162 FSLVLSIVM 170
                 666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (195 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1606  (0.0895755); expected 358.6 (0.02)
Passed bias filter:                      583  (0.0325172); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.62u 0.33s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1106.76
//
Query:       EFC39657.1  [L=362]
Description: LamG domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    5.3e-18   65.6   0.0      8e-18   65.0   0.0    1.2  1  Laminin_G_3  Concanavalin A-like lectin/glucanases superfamil
  ------ inclusion threshold ------
      0.021   14.9   0.0      0.033   14.3   0.0    1.3  1  DUF1080      Domain of Unknown Function (DUF1080)
      0.073   12.7   0.2       0.29   10.8   0.2    2.0  1  Pentaxin     Pentaxin family


Domain annotation for each model (and alignments):
>> Laminin_G_3  Concanavalin A-like lectin/glucanases superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.0   0.0   1.3e-21     8e-18      15     151 ..      69     212 ..      56     213 .. 0.81

  Alignments for each domain:
  == domain 1  score: 65.0 bits;  conditional E-value: 1.3e-21
  Laminin_G_3  15 ptssfTvsaWvkpdslpsaaqiiis.sssdg.rgfelgl..dgsgrlrfsvnagngaeesvtsgasvpageWtHvavtydggtlrlYvNGvevgsa.t 107
                  p +++T  aWv p++ ++  +i+ s  ++++  gf++ l  d    l  + ++   + + v+s +sv+ geW+H++vt+  g++r+Y+NG+++  + +
   EFC39657.1  69 PFDELTMMAWVHPTKHGD-IRIFDSsVAGENfAGFGFDLhmDKVRFLGSRRDDVAVGVNCVSSRRSVRIGEWNHCCVTFKKGEMRFYINGELDVVHlS 165
                  58899************9.6777767667778566655511444455556666677888999*****************************9988856 PP

  Laminin_G_3 108 ltggllsatsgplviGrdp...ggddpfdGlidevriynralsaaeI 151
                  +   l+++  + l iG ++   +g+ ++ G + ++ ++n als+  +
   EFC39657.1 166 DLKMLDPPLQNKLCIGYSMighPGSGYYEGFMSQMSVWNVALSDNHV 212
                  666688889999******997667*******************9876 PP

>> DUF1080  Domain of Unknown Function (DUF1080)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   5.5e-06     0.033     121     149 ..     131     159 ..      78     180 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 5.5e-06
                 --S--TTSEEEEEEEEETTEEEEEETTEE CS
     DUF1080 121 kaakppgeWntyeiivkgdrvtvwlNGvl 149
                 + + ++geWn++ +++k+ +++ ++NG+l
  EFC39657.1 131 RRSVRIGEWNHCCVTFKKGEMRFYINGEL 159
                 567889*********************97 PP

>> Pentaxin  Pentaxin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.2   4.9e-05      0.29      74     170 ..     128     219 ..      45     225 .. 0.69

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 4.9e-05
                 EEEE-SS-SSSEEEEEEEEETTTTEEEEEETTEEEEEE.E-STT--B-SSEEEEESS-BSCTTCTCSGGGB--EEEEEEEEESS---HHHHHHHHHT- CS
    Pentaxin  74 vlvkvseekvepvhvCasWesssGivelwvdGkplvkk.slkkgytvgaeasiilGqeqDsyGGkfdasqslvGelsdlnlWdyvLspeeiktvykga 170
                 v ++ s +  e++h C++++  +G++ ++++G++ v + s  k      + ++ +G     +      s  ++G +s++ +W+++Ls +++++ ++ +
  EFC39657.1 128 VSSRRSVRIGEWNHCCVTFK--KGEMRFYINGELDVVHlSDLKMLDPPLQNKLCIGYSMIGHP----GSGYYEGFMSQMSVWNVALSDNHVEMCSRKN 219
                 33344444559*******96..8*********8755441555555556667788887654443....45679999*************9999988766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (362 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       360  (0.0200792); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.63u 0.36s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 1964.41
//
Query:       EFC39658.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    8.5e-37  126.5   0.0    4.8e-26   91.4   0.0    2.2  2  adh_short     short chain dehydrogenase
      6e-24   84.9   0.0      2e-18   66.8   0.0    2.1  2  adh_short_C2  Enoyl-(Acyl carrier protein) reductase
     0.0013   18.7   0.1      0.012   15.5   0.1    2.0  2  KR            KR domain


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.0   0.0   6.3e-12   3.8e-08       4      62 ..       7      66 ..       4      82 .. 0.88
   2 !   91.4   0.0   8.1e-30   4.8e-26      67     191 ..      93     224 ..      87     227 .. 0.92

  Alignments for each domain:
  == domain 1  score: 33.0 bits;  conditional E-value: 6.3e-12
                EEESTTSHHHHHHHHHHHH.TT-EEEEEESCHHHHHHHHHHHHHTTSEEEEEE-TTTSHH CS
   adh_short  4 lvtGassGIGraiakelak.eGakvvvvdrseekleevakelkeegakalaiqvDvtdre 62
                +vtG s+GIG+ iak l    G +vv++++++ekle+ +k ++++g +a ai vD+++ +
  EFC39658.1  7 IVTGSSRGIGLHIAKSLSClHGHTVVITGSNKEKLENSLKDIHQLGGEAAAICVDLSQPT 66
                8***************97527888888*****************************9765 PP

  == domain 2  score: 91.4 bits;  conditional E-value: 8.1e-30
                 HHHHHHHHHSSESEEEE---S....S--SSGGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHH.HCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHH CS
   adh_short  67 lvekavkklgkldvLvnNAGi....tgsgpfselseeewervievNltgvflltravlpaml.kqssGrIvnvsSvagkvpvagvaaYsAsKaavaglt 160
                 +++ a+ +++++d Lv NAG+    ++ ++ ++ ++++ ++v++vNl +v++l++ +lp++  +  +GrI  vsS a+  +  g++aY++sKaa++++ 
  EFC39658.1  93 IFNFAMRNFKRVDRLVCNAGVigpiQNISQWNHEQATDLNQVFQVNLISVMQLCHYCLPELRkSPDGGRILLVSSGAATRAIDGWSAYCTSKAALNHFG 191
                 678899***************987666666667777779*********************9977889******************************** PP

                 HHHHHHHGGGT..EEEEEEEESSBSSHHHHHHC CS
   adh_short 161 rslakelaptg..irvnavaPGlvdTdmakelr 191
                 ++l  e ++++  + + ++ PG+vdT+m++++r
  EFC39658.1 192 MCLDLEERKQEkpVGILSIRPGVVDTQMQEQIR 224
                 ******9999899****************9987 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0     1e-06    0.0062       1      54 [.      10      66 ..      10      81 .. 0.86
   2 !   66.8   0.0   3.3e-22     2e-18      58     215 ..      92     261 ..      87     271 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1e-06
                  TTTTSHHHHHHHHHH.HTT-EEEEEESSGGH.HHHHHHHHHHTTSE.EEE--TTSHH CS
  adh_short_C2  1 GaasgIGraiAkala.eeGaevvltdlneea.kkrveelaeelgae.vlecDVtdee 54
                  G  +gIG +iAk+l   +G +vv+t  n+e+ +++++++++ +g++ ++ +D ++++
    EFC39658.1 10 GSSRGIGLHIAKSLScLHGHTVVITGSNKEKlENSLKDIHQLGGEAaAICVDLSQPT 66
                  5679********997369*************999*****999888745****99875 PP

  == domain 2  score: 66.8 bits;  conditional E-value: 3.3e-22
                   HHHHHHHHHHSSEEEEEE-----EG..CSS-GGGH-HHHHHHHHHHHTHHHHHHHHHHHHHCTSC...CEEEEEEEGGGTSBSTTTTHHHHHHHHHH CS
  adh_short_C2  58 alveevvekfgklDilvnnagiapk..lkgpfletsreefdraldvnlyslfllakaalplmkeg...gsivnlssvgaervvpnynaygaaKaale 149
                   ++++ ++++f+++D lv nag+  +    ++  + +  +++++++vnl s+++l++++lp ++++   g+i+ +ss +a+r++++ +ay+++Kaal+
    EFC39658.1  92 EIFNFAMRNFKRVDRLVCNAGVIGPiqNISQWNHEQATDLNQVFQVNLISVMQLCHYCLPELRKSpdgGRILLVSSGAATRAIDGWSAYCTSKAALN 188
                   578999*******************654455555678899********************55444466***************************** PP

                   HHHHHHHHHHGG..GTEEEEEEEE--BHCTGGGGSTT.....HHHHHHHHHHHSTTSS-B-HHHHHHHHHHHC CS
  adh_short_C2 150 altrylAvelgp..kgiRvNavspgpikTlaasgikg.....fdelleelearaplgrlgtpeevaeaalfLa 215
                   ++  +l  e  +  k + + ++ pg+++T+++++i+      + + ++++ + +  ++l +pe+++e+ + L+
    EFC39658.1 189 HFGMCLDLEERKqeKPVGILSIRPGVVDTQMQEQIRTvgnveSMKDYKNFVNLHENKELESPEKIGEILACLV 261
                   **999998888733567788999***********998443211122344556666677779999999999887 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   2.1e-06     0.012       4      66 ..       7      66 ..       5      83 .. 0.85
   2 ?    0.9   0.0     0.062   3.7e+02     100     159 ..     126     190 ..      93     203 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 2.1e-06
                EEETTTSHHHHHHHHHHHHHHS-EEEEE-SS..--HHHHHHHHHHHHTT-EEEE----TT-HH CS
          KR  4 litGGlGgLGlelarwlaekgarhlvllsRsaaadedskaliaelealgaevevvaaDvsdkd 66
                ++tG   g+Gl++a+ l   + +++v+++ +   +e+ ++ ++ +++lg e  ++ +D+s+++
  EFC39658.1  7 IVTGSSRGIGLHIAKSLSCLHGHTVVITGSN---KEKLENSLKDIHQLGGEAAAICVDLSQPT 66
                89***************************99...45666689999999999999999999876 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.062
                 --HHHHHHHHTTTTHHHHHHHHHTTT.....S--SEEEEEEEHHHHH--TT-HHHHHHHHHHHHH CS
          KR 100 mtaedleqvlapKvkGawnLhelled.....esldffvlfSSiagllgsagqanYaaaNaflDal 159
                  +a dl+qv++  +  + +L +++ +      +   ++l+SS a++    g ++Y +  a l+ +
  EFC39658.1 126 EQATDLNQVFQVNLISVMQLCHYCLPelrksPDGGRILLVSSGAATRAIDGWSAYCTSKAALNHF 190
                 45556677777766666666555444355223344688999999999999999999888877765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       593  (0.0330749); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.27s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1795.04
//
Query:       EFC39659.1  [L=816]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.9e-38  132.4   6.7    7.9e-38  130.4   6.7    1.9  1  Peptidase_S8  Subtilase family


Domain annotation for each model (and alignments):
>> Peptidase_S8  Subtilase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  130.4   6.7   4.4e-42   7.9e-38       1     282 [.     274     623 ..     274     653 .. 0.83

  Alignments for each domain:
  == domain 1  score: 130.4 bits;  conditional E-value: 4.4e-42
                   -TT-EEEEECS-B-TT-TTTGGGEEE..EEEE---TTSG.GGEETT-SS-TT-SC-SSS....HHHHHHHHHH-B........SSSSSB-SSTTSEE CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxxxxxx RF
  Peptidase_S8   1 gkgvlvavlDtGvdpshpdlsvttdgerklvdvideegagfngadsettstnwarddngnsieHGthvAGiaaan......apeegekngvapgaki 91 
                   gk+ +v+ +DtG++ +h+ + ++  +        + +  +fn+++    +  +  d ng    HG+hvAGi+a+       + +++++ngva +ak+
    EFC39659.1 274 GKNQIVSYIDTGISVEHCLFYDKNAT--------NYTSINFNHKKVVGIEGMDMIDTNG----HGSHVAGIIAGDlssrypSSSMSKRNGVAKNAKL 358
                   7999****************944222........33344699*****999999999999....****************999999************ PP

                   EEEE-SSTTSB-HH..HHHHHHHHHHHH.CT-SEEEE-EE..SCETTCHHCHHHHHH...................................HHHHH CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxx..xxxxxxxxxxxxxxx...................................xxxxx RF
  Peptidase_S8  92 lsvkvldtsggsmetgteliraieeaae.dkvdvinmslg..estslpktgrsieal...................................ainra 150
                   + + + +  +gs  ++ +l + +++a +  + +++++s+g   s+   ++ r++  l                                   +++++
    EFC39659.1 359 YVIDFSSSADGSVASNYDLQGMLNRAYNlAGSRIHSNSWGckPSSYSCDYNRVCYRLkqngqrgaivndtecmaekgvkchqqclgysdqasLMDQF 455
                   **********9999999***********************994444555555555556666666666777777999999999999999999*99*** PP

                   H.CC.T-EEEEE--SS-T-HHEEE-TTCEECTTTSTTCEEEEEES.......................TTSSB-TT--B-TT.......-EEEE-S- CS
                   xxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.......................xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Peptidase_S8 151 vnkk.gvlvviSaGNngktgsslqagspvgtpstsknvitvgayt.......................tegkiapfSsrGpssdgklkpdivapGgn 223
                    +++ ++++v ++GN+g    +++ ++++++p+t+kn ++vga+                            +  fS +Gp++dg++kpd++apG  
    EFC39659.1 456 LYDHdDMIIVQASGNSG----NISLLESISAPATAKNLLSVGAVHnyytsycnstsmsaskceskystFSMGMPLFSGKGPTMDGRNKPDVMAPGHF 548
                   ****9************....7899*****************************************99666699**********************9 PP

                   CCCCCCCCCHHHTTTHHEEEE-SHHHCHHHHHHHHHHHHHHHTT..--HHH......................HHHHHHCCS- CS
                   xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxx......................xxxxxxxxxx RF
  Peptidase_S8 224 ivstwsrqsnnsaglssyqsmsGTSmAsPnaagaaAlllsalpk..ltpet......................vraallntAq 282
                   i+s  s  +      +++ + sGTSm++P ++g+aAl++++l +  +  e                       ++a l+++A 
    EFC39659.1 549 IMSAKSGST------CDFVALSGTSMSTPGVSGSAALVREYLTAnnY--ERlryfnlnntlgenetlsvsgtlIKAFLIHSAL 623
                   554444444......6699*********************9887441..3333444444455555566666777777777775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (816 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.33s 00:00:01.08 Elapsed: 00:00:00.52
# Mc/sec: 4766.66
//
Query:       EFC39660.1  [L=382]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
  ------ inclusion threshold ------
      0.026   15.1   0.1      0.059   14.0   0.1    1.6  1  YdaT_toxin       Putative bacterial toxin ydaT


Domain annotation for each model (and alignments):
>> YdaT_toxin  Putative bacterial toxin ydaT
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.1   3.3e-06     0.059      24      83 ..     280     339 ..     270     346 .. 0.85

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 3.3e-06
  YdaT_toxin  24 ekvreLtPailavLPleyrarllnvdsfmsrlavlekeiseakvavllgapkhqkikels 83 
                 + v   +Pa++  +P+e r+ +++++++   la+++ e+ +  v  l++ + +q  +++s
  EFC39660.1 280 QSVMLGMPALQIEIPMEVRKDMISNEALLDELAKAIVETYKKSVLQLFNKDWEQVETKIS 339
                 6677789********************************999988888888877666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (382 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2153  (0.120085); expected 358.6 (0.02)
Passed bias filter:                      609  (0.0339673); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.51
# Mc/sec: 2240.69
//
Query:       EFC39661.1  [L=178]
Description: ARF/SAR family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.3e-64  214.9   0.1      6e-64  214.7   0.1    1.0  1  Arf              ADP-ribosylation factor family
    4.8e-14   52.3   0.0    5.8e-14   52.0   0.0    1.1  1  Ras              Ras family
    3.4e-12   46.6   0.1    4.7e-12   46.2   0.1    1.2  1  Roc              Ras of Complex, Roc, domain of DAPkinase
    1.2e-11   44.4   1.7    1.6e-08   34.1   0.2    2.3  2  G-alpha          G-protein alpha subunit
    2.3e-10   40.2   0.0    2.8e-10   39.9   0.0    1.1  1  SRPRB            Signal recognition particle receptor beta su
    5.3e-07   29.2   0.0    6.9e-07   28.8   0.0    1.2  1  Gtr1_RagA        Gtr1/RagA G protein conserved region
    0.00037   20.5   0.0    0.00057   19.9   0.0    1.3  1  MMR_HSR1         50S ribosome-binding GTPase
  ------ inclusion threshold ------
       0.18   11.7   0.0       0.27   11.1   0.0    1.3  1  Arabinose_Iso_C  L-arabinose isomerase C-terminal domain


Domain annotation for each model (and alignments):
>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  214.7   0.1   2.7e-67     6e-64       3     174 ..       7     177 ..       5     178 .] 0.96

  Alignments for each domain:
  == domain 1  score: 214.7 bits;  conditional E-value: 2.7e-67
                 HHHHGGTT..TTEEEEEEEESTTSSHHHHHHHHHHSSCEECSSSSSEEEEEEEETTEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHH CS
         Arf   3 silaklklk.kkelrilllGLDnaGKtTilkklkleelvttvPTigfnveeleiknlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleea 100
                 +++++l l  +k+++il+lGLD+aGKt  l+k++l+e v+t+PTigfn e +++k ++f+v+D+GGq+k+R lW++Y++ tdavif+vDs+dreR+ee 
  EFC39661.1   7 NMIKNLSLFeNKQAKILFLGLDAAGKTSTLYKIQLDENVNTIPTIGFNAEVIQYKRVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVDSNDRERFEEV 105
                 56666665449**************************************************************************************** PP

                 HHHHHHHCTSGCCTTSEEEEEEE-TTSTTSS-HHHHHHHTTGGGSSSSSSEEEEEEBTTTTBTHHHHHHHHHHH CS
         Arf 101 keeLkalleeeelkevallvlaNKqDlpealseeelrellgleelkgkrkleiqkcsavkgeglkeglewlses 174
                 +e L++++e+  l++++llv+aNKqDlp a++ ++l+++l+l+++k  ++++iq csa++g+gl egl+wls++
  EFC39661.1 106 SETLHKVMEDPSLSNAKLLVWANKQDLPRAANVTDLAKILQLNSIK--QDWYIQPCSAMNGTGLFEGLDWLSSK 177
                 **********************************************..9**********************976 PP

>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.0   0.0   2.6e-17   5.8e-14       1     147 [.      21     165 ..      21     177 .. 0.81

  Alignments for each domain:
  == domain 1  score: 52.0 bits;  conditional E-value: 2.6e-17
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikr 99 
                 K++++G  a GKts l++   d+   + ++Tig++  +    ++ k+v+++++D  Gq++ ++l + yy+++++++ + d ++re fe+v++ ++++ +
  EFC39661.1  21 KILFLGLDAAGKTSTLYKIQLDENV-NTIPTIGFNAEV----IQYKRVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVDSNDRERFEEVSETLHKVME 114
                 899**************98888865.569***887654....66789********************************************99999998 PP

                 HST.TTSEEEEEEETTTGGGG-SS-H.HHHHHHHHHHTSEEEE.EBTTTTC CS
         Ras 100 vae.envpivLvGnKvDleekravst.eegeelakelglkfle.tSAktne 147
                   + +n ++++ +nK Dl +  +v+  ++  +l + ++  +++ +SA + +
  EFC39661.1 115 DPSlSNAKLLVWANKQDLPRAANVTDlAKILQLNSIKQDWYIQpCSAMNGT 165
                 8888999***********998877641344444444443444336666665 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.2   0.1   2.1e-15   4.7e-12       1     119 [.      21     131 ..      21     132 .. 0.76

  Alignments for each domain:
  == domain 1  score: 46.2 bits;  conditional E-value: 2.1e-15
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEEGHHH...HCHH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvydsrss...enlk 96 
                 K++++G  ++GKts l +++ d+   ++ +tig +    +             k+v+++++D++Gq+++r+l ++y+++ +++i+++ds++    e+++
  EFC39661.1  21 KILFLGLDAAGKTSTLYKIQLDEN-VNTIPTIGFNAEVIQ------------YKRVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVDSNDRerfEEVS 106
                 99***************9987665.67799***9874322............35799******************************966550114555 PP

                 HHHHHHHHH..CSSS-EEEEEE-TT CS
         Roc  97 eWlkelkkv..agkspvilvgnkiD 119
                 e l+++ +    +++++++ +nk D
  EFC39661.1 107 ETLHKVMEDpsLSNAKLLVWANKQD 131
                 5554444432234667888899998 PP

>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.1   0.00018       0.4      19      45 ..      17      41 ..       3      47 .. 0.81
   2 !   34.1   0.2     7e-12   1.6e-08     186     281 ..      48     132 ..      41     135 .. 0.89

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00018
                XE..EEEEEEEESTTSSHHHHHHHHHH CS
     G-alpha 19 kkkrevkllllGqseSGKsTilkqlkl 45
                +  ++ k+l+lG +  GK+++l +++l
  EFC39661.1 17 N--KQAKILFLGLDAAGKTSTLYKIQL 41
                3..489*****************9995 PP

  == domain 2  score: 34.1 bits;  conditional E-value: 7e-12
                 ----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHH CS
     G-alpha 186 lktvGisetkfevdsklefrivdvgGqrserkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDi 281
                 ++t+G++   ++++  ++fr++d+gGq + r  W ++++++da+iF+v           ++   r+ee  +  +++++ + l n+++++  nK D+
  EFC39661.1  48 IPTIGFNAEVIQYK-RVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVD----------SNDRERFEEVSETLHKVMEDPSLSNAKLLVWANKQDL 132
                 6899*********9.********************************97..........4455799999999999999999999999999999986 PP

>> SRPRB  Signal recognition particle receptor beta subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.9   0.0   1.3e-13   2.8e-10       2     128 ..      18     136 ..      17     150 .. 0.87

  Alignments for each domain:
  == domain 1  score: 39.9 bits;  conditional E-value: 1.3e-13
                 ---EEEEE-STTSSHHHHHHHHHHSS---B---S.S-EEETTG...GGTT-SEEEETT-GCCSHHHHHHHHHHGGEEEEEEEEETTS-HHHHHHHHHHH CS
       SRPRB   2 skpavllvGlsdsGKTslftrLttdsvkktvtSq.essaalkvksekgskltliDfPGheklrqklleklkaksslkglvfvvDStidpkevkevAEll 99 
                 ++ ++l++Gl  +GKTs + ++  d+  +t   +  +  + ++   k  ++++ D+ G++k+r+   +   + +   +++f+vDS  d  + +ev E l
  EFC39661.1  18 KQAKILFLGLDAAGKTSTLYKIQLDENVNTIPTIgFNAEVIQY---KRVQFRVFDIGGQDKIRTLWRH---YYNGTDAVIFIVDSN-DRERFEEVSETL 109
                 6889****************************99878888888...99***************85554...578899*******97.78889******* PP

                 HHHHHHHHHHTT---EEEEEE-TTSTT-- CS
       SRPRB 100 yeilliteklkdavdiliACnKqelflak 128
                  +++ +  +   + ++l+  nKq+l  a 
  EFC39661.1 110 HKVMEDPSL--SNAKLLVWANKQDLPRAA 136
                 ****99984..45689999*****97665 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.8   0.0   3.1e-10   6.9e-07       1     124 [.      21     133 ..      21     153 .. 0.82

  Alignments for each domain:
  == domain 1  score: 28.8 bits;  conditional E-value: 3.1e-10
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrlgatidveksevrflgnltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesre.leedletl 98 
                 k+L++G   +GKts    ++ +++  + ++   ti  + + +  ++ +++ ++D+gGq+++ +        + ++  +++i+++D+++re +ee  etl
  EFC39661.1  21 KILFLGLDAAGKTST---LY-KIQLDENVNTIPTIGFNAEVI-QYKRVQFRVFDIGGQDKIRTLW-----RHYYNGTDAVIFIVDSNDRErFEEVSETL 109
                 89***********95...44.556666777778999999888.6899************987764.....789999***********997799999999 PP

   Gtr1_RagA  99 keilealrqyspeakvfvlihKmDli 124
                 ++++e  +    +ak+ v  +K Dl 
  EFC39661.1 110 HKVMEDPS--LSNAKLLVWANKQDLP 133
                 99998754..4567778888888875 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   0.0   2.6e-07   0.00057       2     114 .]      22     129 ..      21     129 .. 0.68

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 2.6e-07
                 EEEEESTTSSHHHHHHHH.HTSTEEESSSTTSSSSEEEEEEEETTEEEEEEECGGCSSHHHHHHHHHHHHHHHHC.TSEEEEEEETT.TTCSHHHHHHH CS
    MMR_HSR1   2 vaivGrpNvGKStLinal.tgekaivsdkpgtTrdinegrvklkgkeielvDtpGliegaseekglgkaflalee.adlillvvdas.eeklkpldeel 97 
                 ++++G   +GK++ + ++ ++e++ +  +p  T+  n + +++k+ ++++ D+ G  +      +++  ++   + +d+++++vd++ +e ++++ e+l
  EFC39661.1  22 ILFLGLDAAGKTSTLYKIqLDENVNT--IP--TIGFNAEVIQYKRVQFRVFDIGG-QD------KIRTLWRHYYNgTDAVIFIVDSNdRERFEEVSETL 109
                 8899*******999999834444444..44..444444444444667********.44......3444444444458********77756799999999 PP

                 HHHHHH...TTSEEEEEEES CS
    MMR_HSR1  98 eellee...akkplilvlnk 114
                 ++++e+   ++ +l++ +nk
  EFC39661.1 110 HKVMEDpslSNAKLLVWANK 129
                 99987677766667776665 PP

>> Arabinose_Iso_C  L-arabinose isomerase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00012      0.27       3      78 ..      62     137 ..      60     139 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00012
                      EEEE---TTTS-S--EEEE-BB--EEEEEEEEEE-SSSEEEEEEEEEEE--SS--TT--S-EE.EEEESS-HHHHHH CS
  Arabinose_Iso_C   3 rlevhplgiGgkedparlvFeakagkavvvslvdlgdrfrlivnevevvkpeeelpkLpvara.lwkpkpdlktaae 78 
                      r++ + ++iGg+++  +l  +  +g++ v+ +vd +dr r+   + e++++  e p+L  a+  +w  k+dl +aa+
       EFC39661.1  62 RVQFRVFDIGGQDKIRTLWRHYYNGTDAVIFIVDSNDRERFEEVS-ETLHKVMEDPSLSNAKLlVWANKQDLPRAAN 137
                      788999*****************************8877764333.3444446678888888527999999988875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (178 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       563  (0.0314016); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        51  (0.00284455); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.51u 0.31s 00:00:00.82 Elapsed: 00:00:00.48
# Mc/sec: 1110.21
//
Query:       EFC39662.1  [L=933]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.6e-11   43.0   0.1      1e-10   41.5   0.1    1.8  1  Pkinase         Protein kinase domain
      2e-07   30.6  44.7     0.0074   16.0   2.3    9.3  8  DUF4116         Domain of unknown function (DUF4116)
      1e-05   25.2   0.1    2.1e-05   24.2   0.1    1.6  1  RCC1_2          Regulator of chromosome condensation (RCC1) r
    6.3e-05   22.4   0.0    0.00011   21.5   0.0    1.5  1  Pkinase_Tyr     Protein tyrosine kinase
  ------ inclusion threshold ------
      0.012   16.0   1.7        2.7    8.5   0.1    2.8  2  SopA            SopA-like central domain
      0.046   14.3   0.6        1.9    9.2   0.1    2.5  2  RCC1            Regulator of chromosome condensation (RCC1) r
       0.12   12.4   0.4       0.39   10.8   0.0    2.0  2  Glyco_hydro_4C  Family 4 glycosyl hydrolase C-terminal domain
        2.6    8.6  10.3        4.8    7.8   0.3    4.2  4  EF-G-binding_N  Elongation factor G-binding protein, N-termin


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.5   0.1   4.4e-14     1e-10     117     212 ..     203     308 ..     201     379 .. 0.69

  Alignments for each domain:
  == domain 1  score: 41.5 bits;  conditional E-value: 4.4e-14
                 TTEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH..........TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSS CS
     Pkinase 117 kgiiHrDlKpeNiLidekge....lKitDFGlakelessskltsfvgtseYlAPEvl..........keneyskkvDvWslGvilyelltgkppfsgek 201
                 k+++HrD+K +NiL++e  +    + +tDFG++ + +s ++++  +gt++Y  PE+            e ++++++D+++lGv+l  l +++++ s   
  EFC39662.1 203 KELCHRDVKIANILVKEITDsniyVVLTDFGVSFKKNSYKPYQFKTGTEQYYDPEIEkyfntekrglLEFPFKTETDLYALGVTLERLSNKTTINSTPL 301
                 6789************64334588********************************97777654433347889************99988887766222 PP

                 HHHHHHHHHHT CS
     Pkinase 202 gkekvekeldq 212
                  k    ++++ 
  EFC39662.1 302 LK----EIITS 308
                 22....22222 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.1   1.1   0.00023       0.5       6      48 ..     348     388 ..     347     389 .. 0.91
   2 !   16.0   2.3   3.3e-06    0.0074       1      49 []     475     522 ..     456     522 .. 0.97
   3 ?    3.3   0.2      0.03        67       6      49 .]     531     580 ..     528     580 .. 0.77
   4 ?    4.6   0.3     0.012        26       1      48 [.     551     603 ..     551     604 .. 0.84
   5 ?    0.6   0.5      0.21   4.7e+02      24      36 ..     689     701 ..     614     715 .. 0.71
   6 !    5.3   3.1    0.0072        16       1      31 [.     760     791 ..     760     818 .. 0.81
   7 ?    2.2   0.0     0.066   1.5e+02      25      41 ..     856     872 ..     831     879 .. 0.76
   8 !   13.7   0.7   1.7e-05     0.038       1      30 [.     881     910 ..     881     911 .. 0.97

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00023
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 l+a+  n+++lk+++  + ++k ++ k + +n  ++++++++L
  EFC39662.1 348 LHACVMNPNCLKFCP--YNKNKRFIYKVLDNNHRIFEMVPDDL 388
                 678888*********..559*********************99 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 3.3e-06
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas.eeLr 49 
                 +r iv   +kk  ++++++s  ++ D ei+   +++n++++  +s +eLr
  EFC39662.1 475 NRNIVFSFIKKVEECFQHCS--YRDDEEIIQYVLEKNPKFITDISsDELR 522
                 799*****************..9********************9988898 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.03
     DUF4116   6 leavkkngsalkylseeLknDkeivlkAvkqngt......alsyaseeLr 49 
                 +e+++ ++  +  lse+  +D+ +++ A+k +++      +++ ++e+L+
  EFC39662.1 531 KEILEVDPTFYASLSESSLKDRLFAKLAMKGCKSqrdfdsNFNCLPEDLK 580
                 67777888888889999888998888888877766667778999999886 PP

  == domain 4  score: 4.6 bits;  conditional E-value: 0.012
     DUF4116   1 DrEivleavkkngs......alkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 Dr +++ a+k + s      +++ l+e+Lk   ++ ++++  n++ +  + ++L
  EFC39662.1 551 DRLFAKLAMKGCKSqrdfdsNFNCLPEDLK-TQDFFIEIITENSKTFHNLKDHL 603
                 89999999998877777888*********9.99999999999998887666665 PP

  == domain 5  score: 0.6 bits;  conditional E-value: 0.21
     DUF4116  24 knDkeivlkAvkq 36 
                 ++D +++lk++ +
  EFC39662.1 689 QHDADFILKIITR 701
                 4577777777765 PP

  == domain 6  score: 5.3 bits;  conditional E-value: 0.0072
     DUF4116   1 DrEivleavkkngsalkyls.eeLknDkeivl 31 
                 D E+v e++++++  +++ls ++L+n+  i+ 
  EFC39662.1 760 DIELVNEIIEIYPALYENLScNNLRNNQIIIE 791
                 89******************888998776654 PP

  == domain 7  score: 2.2 bits;  conditional E-value: 0.066
     DUF4116  25 nDkeivlkAvkqngtal 41 
                  Dke++l ++++ + a+
  EFC39662.1 856 DDKEFMLPILEKFPRAY 872
                 57777777777776666 PP

  == domain 8  score: 13.7 bits;  conditional E-value: 1.7e-05
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeiv 30 
                 D+Ei++ +++k+ +++++l+  +++D ei+
  EFC39662.1 881 DKEIIKMVIRKYDEIYEHLDTTFQKDEEIL 910
                 9***************************96 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   0.1   9.4e-09   2.1e-05       1      30 []     123     152 ..     123     152 .. 0.97

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 9.4e-09
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +k+vs+G+ H  +L+e+G V++ G N++ Q
  EFC39662.1 123 IKKVSSGYGHCAVLLENGQVFTRGLNNYNQ 152
                 79*************************998 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.0   5.1e-08   0.00011     122     200 ..     203     292 ..     201     360 .. 0.73

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 5.1e-08
                  TTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE..........EEHHHHHHHHHHHHHHHHT CS
  Pkinase_Tyr 122 kklvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk..........ftsksDvWsfGvllwEift 200
                  k+l Hrd+   N+L++e    n  v ++DfG++ + +   +y+  + ++   +++ pE+ k+ +          f++++D ++ Gv+l  + +
   EFC39662.1 203 KELCHRDVKIANILVKEitdsNIYVVLTDFGVSFKKN---SYKPYQFKTGTEQYYDPEIEKYFNtekrgllefpFKTETDLYALGVTLERLSN 292
                  7899************98887889*********9884...4444445555567888887665555578999999************9965554 PP

>> SopA  SopA-like central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.2    0.0075        17      31     104 ..     358     441 ..     352     450 .. 0.64
   2 ?    8.5   0.1    0.0012       2.7      19      56 ..     478     520 ..     470     601 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0075
                 HTSTTTTC-HH.HHHHHHHHHHHHHH.---.HHHHHHTHHHHHHH......HHHTTTHHHHTHHHHHHHHH.HHHC-TT.-HHHH CS
        SopA  31 lshaPYidepl.iaewlqeveerffa.afD.imrqqrvlevllDt......FdrnkelmvkhsalFiqvia.qaltavd.tdatk 104
                 l  +PY ++   i + l++   r f+ ++D ++  + v + + D        +rnk+ ++k  +l  q+i+ ++l+ v+ +++ +
  EFC39662.1 358 LKFCPYNKNKRfIYKVLDNN-HRIFEmVPDdLLDENIVRKSIRDVrsvlifQNRNKACIDKFKSLISQLIDvHVLRNVQyNTGKR 441
                 56688877654144444444.44444355533333334444444466666469*****************868999998666555 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0012
                 HHGGGHHHHHHHHTSTTTTC-HHHHHHHHHHHHHHHH.....- CS
        SopA  19 slksvaesllkilshaPYidepliaewlqeveerffa.....a 56 
                 ++ s+++ + + + h+ Y d+  i +++ e + +f+       
  EFC39662.1 478 IVFSFIKKVEECFQHCSYRDDEEIIQYVLEKNPKFITdissdE 520
                 55678999999************************99553331 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.078   1.7e+02      35      50 .]     120     136 ..     112     136 .. 0.77
   2 ?    9.2   0.1   0.00083       1.9       1      20 [.     139     158 ..     139     185 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.078
                 S.-EEEEEEETTEEEEE CS
        RCC1  35 n.rvvkvacGddhtval 50 
                 n  ++kv++G+ h+++l
  EFC39662.1 120 NsGIKKVSSGYGHCAVL 136
                 33899*********986 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00083
                 TTEEEEEE--GGGTTSSSS- CS
        RCC1   1 dGrVysWGrndyGqLGlgtt 20 
                 +G+V++ G n+y+q+ +g+ 
  EFC39662.1 139 NGQVFTRGLNNYNQCANGDV 158
                 69**************9987 PP

>> Glyco_hydro_4C  Family 4 glycosyl hydrolase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       1.9   4.2e+03      58     102 ..     458     518 ..     404     546 .. 0.50
   2 ?   10.8   0.0   0.00017      0.39       3      70 ..     736     812 ..     735     871 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.9
                     ECGGHHCTTSS.............HCHHHHSHHHHHHH.....HHHHHHHHHHHTTTTTHHH CS
  Glyco_hydro_4C  58 teysrhyaEYvp............ylkreapeliekek.....traevvkevekelfeelek 102
                      ey+  + +Y+p            ++k+ ++e  ++       +  + v e + ++++++++
      EFC39662.1 458 VEYDSLFFNYFPfkykfnrnivfsFIKK-VEECFQHCSyrddeEIIQYVLEKNPKFITDISS 518
                     3666666677776665444444443331.222222211222222222333344444444444 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00017
                     EETTEEEEEEEECTTEEHHHHHHHHHHH.HHHHHHCTGGGTSHHHHHHHHHHSSEEECGGHHCTTSS............H CS
  Glyco_hydro_4C   3 GlNHlaWllkledkGeDlypelrelvee.dewleeiaekkaervridllrrlgllpteysrhyaEYvp...........y 70 
                     G  Hl+   +++++G++l+++  + +e  +e +e + +   e+ +++ lr+ ++++ +y++h+  Y+p           +
      EFC39662.1 736 GFSHLIHAIEVKEQGNELMQKCSDDIELvNEIIEIYPAL-YENLSCNNLRNNQIIIETYLNHT--YFPrlskdlklddeF 812
                     788*********99********99887665555555555.57799******************..999744443322221 PP

>> EF-G-binding_N  Elongation factor G-binding protein, N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.3    0.0021       4.8      11      56 ..     412     457 ..     409     462 .. 0.91
   2 ?   -1.8   0.1         2   4.5e+03      10      39 ..     483     511 ..     476     537 .. 0.51
   3 ?    4.7   0.1      0.02        44      46      77 ..     621     653 ..     587     658 .. 0.86
   4 ?   -1.0   0.1       1.2   2.6e+03      26      65 ..     881     919 ..     872     932 .. 0.59

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0021
  EF-G-binding_N  11 kkqveqllnayrsvnDkkvveavkalaaekIlelfpelseeqkelL 56 
                     k ++++  +  ++  D +v++ v+ ++ ++I+  +++lse q e+L
      EFC39662.1 412 KACIDKFKSLISQLIDVHVLRNVQYNTGKRIQIEMEKLSESQLEIL 457
                     78999999999*********************99999*****9998 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 2
  EF-G-binding_N  10 IkkqveqllnayrsvnDkkvveavkalaae 39 
                     Ikk ve+  + ++   D+++++ v +   +
      EFC39662.1 483 IKK-VEECFQHCSYRDDEEIIQYVLEKNPK 511
                     332.34444444444444444444444444 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.02
  EF-G-binding_N  46 pelseeqkelLeqiddik.tkekaeklLeeLke 77 
                     ++  + ++++L++i + k ++e++ek+L+ L e
      EFC39662.1 621 EDRRKMDRDILRKILSDKfSSEEIEKILNCLSE 653
                     555666799********************9987 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.2
  EF-G-binding_N  26 DkkvveavkalaaekIlelfpelseeqkelLeqiddiktk 65 
                     Dk++++ v     ++I e +    ++++e+L+ ++++k++
      EFC39662.1 881 DKEIIKMVIRKY-DEIYEHLDTTFQKDEEILSVLNEPKSS 919
                     555555555543.345555555556666666666665533 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (933 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       856  (0.0477439); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.78u 0.33s 00:00:01.11 Elapsed: 00:00:00.52
# Mc/sec: 5402.09
//
Query:       EFC39663.1  [L=2481]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.4e-45  153.4   7.9    8.4e-45  153.4   7.9    3.4  3  REJ       REJ domain
    1.1e-27   96.1 338.1    0.00013   22.3   7.7   23.3 21  EGF_2     EGF-like domain
  ------ inclusion threshold ------
       0.14   10.8   0.2        0.2   10.2   0.2    1.1  1  Cullin    Cullin family


Domain annotation for each model (and alignments):
>> REJ  REJ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -9.0   6.8         3   1.8e+04     258     258 ..     707     707 ..     627     792 .. 0.55
   2 !    3.6   0.0     0.004        24     103     181 ..    1648    1710 ..    1627    1736 .. 0.61
   3 !  153.4   7.9   1.4e-48   8.4e-45     136     449 ..    1840    2141 ..    1766    2143 .. 0.81

  Alignments for each domain:
  == domain 1  score: -9.0 bits;  conditional E-value: 3
         REJ 258 k 258
                  
  EFC39663.1 707 T 707
                 1 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.004
         REJ  103 LdGseSyDpdeddhsqsqlsYeWlcrrsqpmngrnndnpllnidpealsgtllssstssltfpaselvanltynftltv 181 
                  L++ +S   d+       l+++W+c++  +++  ++  +l +++++ ++          + + +  l a++ y +++ v
  EFC39663.1 1648 LNAFDSVSLDRR-----PLTFSWTCTNGPSSEDQSKLSSLISSQKSGYK----------INMRTAGLSAGI-YSIQVAV 1710
                  555555555544.....58899999666644444444444444444444..........444444444442.4444444 PP

  == domain 3  score: 153.4 bits;  conditional E-value: 1.4e-48
         REJ  136 rnndnpllnidpeals.......................gtllssstssltfpaselvanltynftltvskrsrksasteqtilvvdgepplvsiec 209 
                  +  d +++++dp  +s                       g ++ ss    + +  ++ ++ ty+ft +++k+srk++ t    l+++ + +++++++
  EFC39663.1 1840 SVPDITQSKDDPIEFSisvkdpsntqdvlslstncvdstGLNCPSSPEDASTFRASFSSG-TYTFTAVATKGSRKAKATLTISLIDSAKDKIIRVSI 1935
                  444445555555555555555555555555555555567666666666666668889999.8************999999999999*********** PP

         REJ  210 isncngkvnpndrlvllasclncakdlkdvtfeWslsqtseeysllpdkatsslttgterprLvikenkLqsgesyaltlrvtdkegkksglasisf 306 
                  isn++ ++ + ++  +l++ ++++k l + +f+W                 s++ + ++ + L+i + +L sg+sy +tl   + +g+ksg as +f
  EFC39663.1 1936 ISNVDLTTVDPTKDLYLTY-NTLDK-LLSPSFSW----------------VSETGDESKASLLTIPSANLVSGASYVVTL--LVDDGDKSGIASLTF 2012
                  *****99999999888888.44444.778999**................678888888999******************..899999999****** PP

         REJ  307 kvnepPtgGtcsvtPlegvaletaftvrC.qgwtDkdqPLgYevsysqrrasgpyrllyegsnnisisviLPvGppqqdykvtvmvsVyDnkgarvs 402 
                  +vn+pPt+Gt++v+P+ gval+++f+++C +gw+D+++PL++++ + +++as++++  +e+s+ +s sv LP++ +  + ++ v+++VyD++ga+++
  EFC39663.1 2013 TVNSPPTKGTFEVYPEIGVALSDSFDLKCgNGWSDPQTPLKFQF-FYYDSASTKWNSFTEKSERQSASVQLPQPAS--GTSLRVKAVVYDSLGAASE 2106
                  ********************************************.*******************************..89***************** PP

         REJ  403 vsltitVkppavnnstieellenrtrnenelskllesgdtqrakqll 449 
                    +t+t+++ +++++            +++ls++++ +dt ++++ +
  EFC39663.1 2107 SETTVTITKLSAAAA------------TSALSVIASGKDTVTLAAAS 2141
                  **************9............88888888888887777665 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   7.6   0.00069       4.1       6      23 ..      37      54 ..      33      63 .. 0.74
   2 !    9.6   7.8    0.0002       1.2       7      32 .]     226     251 ..     221     251 .. 0.79
   3 !   10.8   8.4     8e-05      0.48       5      28 ..     264     286 ..     260     289 .. 0.83
   4 !    9.7   8.4   0.00019       1.1       6      32 .]     302     328 ..     293     328 .. 0.87
   5 ?    2.7   5.3     0.028   1.7e+02       1      25 [.     335     358 ..     335     361 .. 0.75
   6 !   22.3   7.7   2.2e-08   0.00013       5      32 .]     515     541 ..     511     541 .. 0.91
   7 !   14.9  11.4   4.2e-06     0.025       5      32 .]     555     580 ..     547     580 .. 0.88
   8 !   11.8   9.7   4.1e-05      0.24       6      32 .]     596     621 ..     591     621 .. 0.87
   9 !   15.6   9.4   2.5e-06     0.015       1      32 []     779     805 ..     777     805 .. 0.92
  10 !   11.1  11.8   6.4e-05      0.38       8      32 .]     823     844 ..     818     844 .. 0.86
  11 !    7.1   9.3    0.0012       7.1       5      32 .]     859     887 ..     854     887 .. 0.77
  12 !   18.4  14.9   3.6e-07    0.0021       5      32 .]    1042    1067 ..    1038    1067 .. 0.92
  13 !   12.6   7.6   2.3e-05      0.14       7      32 .]    1228    1252 ..    1224    1252 .. 0.94
  14 !   16.5   8.9   1.4e-06    0.0083       5      32 .]    1265    1291 ..    1257    1291 .. 0.89
  15 ?   -1.7  10.2      0.65   3.9e+03       8      27 ..    1306    1324 ..    1301    1342 .. 0.58
  16 !   18.2   7.0   4.1e-07    0.0024       5      32 .]    1355    1381 ..    1351    1381 .. 0.90
  17 ?    2.0  13.3     0.045   2.7e+02       5      29 ..    1394    1419 ..    1390    1436 .. 0.86
  18 !   10.6  12.9   9.4e-05      0.56       1      32 []    1441    1470 ..    1441    1470 .. 0.88
  19 ?    1.6   0.8      0.06   3.6e+02      22      32 .]    1472    1482 ..    1472    1482 .. 0.95
  20 !   15.2   6.4   3.4e-06      0.02       1      27 [.    1486    1510 ..    1486    1514 .. 0.87
  21 ?   -1.8   1.5      0.71   4.2e+03      14      32 .]    1516    1530 ..    1515    1530 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.00069
       EGF_2  6 eiCgghGtCvnqcGq.CdC 23
                e C+g+G C+ ++G+ C+C
  EFC39663.1 37 ESCNGRGFCN-PEGNsCRC 54
                57********.77877*** PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.0002
       EGF_2   7 iCgghGtCvnqcGqCdC..dsgyqGktC 32 
                  C+g+G+C +  G C+C  +  + G +C
  EFC39663.1 226 VCNGRGICTE-SG-CKCnsPEVWGGSDC 251
                 6*******93.35.***77777888888 PP

  == domain 3  score: 10.8 bits;  conditional E-value: 8e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyq 28 
                 +  C+g GtCv+++ +C C  g++
  EFC39663.1 264 SKVCNGKGTCVATN-NCTCTGGHY 286
                 678*******9666.8****9998 PP

  == domain 4  score: 9.7 bits;  conditional E-value: 0.00019
       EGF_2   6 eiCgghGtCvnqcGqCdC.dsgyqGktC 32 
                 + C+g G+C +    CdC + +y+G +C
  EFC39663.1 302 NVCSGAGKCTADD-TCDCiNLSYTGSNC 328
                 78*******8666.8************* PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.028
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdC.ds 25 
                 C++    C+ +G+C n+   C+C ++
  EFC39663.1 335 CES-AKSCHYRGSCLNSS-LCSCtND 358
                 665.367*******8555.8***654 PP

  == domain 6  score: 22.3 bits;  conditional E-value: 2.2e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 d+ C+g+G+C+ ++ qC C++gy G  C
  EFC39663.1 515 DNVCSGNGQCIGLN-QCLCKAGYNGTFC 541
                 799********777.************9 PP

  == domain 7  score: 14.9 bits;  conditional E-value: 4.2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +++C+g+G C  + G C+C+++++G +C
  EFC39663.1 555 KLACSGNGNCT-FSG-CSCKASFYGSDC 580
                 789*******8.688.************ PP

  == domain 8  score: 11.8 bits;  conditional E-value: 4.1e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                   C+ hG C + + +C+C +gy G  C
  EFC39663.1 596 FVCNSHGNCTTDN-VCVCGQGYNGTFC 621
                 67*******9555.9***********9 PP

  == domain 9  score: 15.6 bits;  conditional E-value: 2.5e-06
       EGF_2   1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 C+  d  C +hG+C+  +G+C Cdsgy G  C
  EFC39663.1 779 CK--DIVC-VHGKCI--EGVCNCDSGYIGTLC 805
                 77..6789.6*****..*************99 PP

  == domain 10  score: 11.1 bits;  conditional E-value: 6.4e-05
       EGF_2   8 CgghGtCvnqcGqCdCdsgyqGktC 32 
                 C  +GtC   +G+C+Cd+gy+G  C
  EFC39663.1 823 CY-NGTCL--EGKCSCDTGYTGTMC 844
                 65.6****..************999 PP

  == domain 11  score: 7.1 bits;  conditional E-value: 0.0012
       EGF_2   5 deiCgghGtCvnqcGqCdC...dsgyq.GktC 32 
                 +++C  +GtC    G+C C   ++ ++ G+tC
  EFC39663.1 859 NNQCV-NGTCL--AGKCICqstPDYFYyGPTC 887
                 45574.8****..9*****999666556***9 PP

  == domain 12  score: 18.4 bits;  conditional E-value: 3.6e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  d  C+ hGtC   +G+C Cdsgy G++C
  EFC39663.1 1042 DVSCSDHGTCK--NGRCICDSGYEGNNC 1067
                  567********..*************** PP

  == domain 13  score: 12.6 bits;  conditional E-value: 2.3e-05
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+g G+C++q  +C+C +gy G +C
  EFC39663.1 1228 VCSGKGSCISQD-VCRCVTGYDGTNC 1252
                  7********999.9***********9 PP

  == domain 14  score: 16.5 bits;  conditional E-value: 1.4e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g G+Cv++   C C+sg +G++C
  EFC39663.1 1265 ASVCSGKGSCVAPD-TCICKSGSTGAKC 1291
                  679********999.9************ PP

  == domain 15  score: -1.7 bits;  conditional E-value: 0.65
       EGF_2    8 CgghGtCvnqcGqCdCdsgy 27  
                  C+ +G C+++   C C+ ++
  EFC39663.1 1306 CSLRGACNATD-TCICKGNF 1324
                  77777777555.67775444 PP

  == domain 16  score: 18.2 bits;  conditional E-value: 4.1e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ Cg +G C +++ +C+C sgy+G  C
  EFC39663.1 1355 SSVCGSRGECTAPN-NCSCRSGYSGSIC 1381
                  678********999.8*********988 PP

  == domain 17  score: 2.0 bits;  conditional E-value: 0.045
       EGF_2    5 deiCgg..hGtCvnqcGqCdCdsgyqG 29  
                  ++ Cgg  +G+C++++  C+C +++  
  EFC39663.1 1394 SNVCGGstRGKCIAPN-TCECVANWNN 1419
                  789**********999.9***999974 PP

  == domain 18  score: 10.6 bits;  conditional E-value: 9.4e-05
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cs+  e+C+ hG+C++   +C+C+ ++ G  C
  EFC39663.1 1441 CSP-TETCNSHGSCDSNF-KCVCNGNFDGEFC 1470
                  877.599*******9444.8**********99 PP

  == domain 19  score: 1.6 bits;  conditional E-value: 0.06
       EGF_2   22 dCdsgyqGktC 32  
                  +C+sg+ G++C
  EFC39663.1 1472 SCKSGFVGDKC 1482
                  5********** PP

  == domain 20  score: 15.2 bits;  conditional E-value: 3.4e-06
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgy 27  
                  Csa  ++C+ hGtC  ++G C+C  +y
  EFC39663.1 1486 CSA-ATTCNSHGTCT-KTGTCYCTGNY 1510
                  998.599*******8.699****8877 PP

  == domain 21  score: -1.8 bits;  conditional E-value: 0.71
       EGF_2   14 CvnqcGqCdCdsgyqGktC 32  
                  C+   G  +C +g+ G+ C
  EFC39663.1 1516 CI--PG--KCLNGFRGDAC 1530
                  55..55..89999999999 PP

>> Cullin  Cullin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.2   3.4e-05       0.2     300     405 ..    2156    2266 ..    2113    2268 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 3.4e-05
      Cullin  300 e..kektedakkyveklLelkdkfdklvkeafn...ndkefekaldeafeefvnknkvnsksaellakYiDelLkkglkglseeeleekldkvlvlf 391 
                  e  ++++++a+++ e++L+ + k + + + +     n+ +f++++  ++++ + +++++sk+ e lak +    k+++ +ls++ +e + + +  ++
  EFC39663.1 2156 EqkAAIQQAASSITEAFLNQQAKAEAVTSVSSAsaeNSLSFTASVSASVAKGLVSDSTTSKVVENLAKTTSAVVKSSSASLSNSAIEGTTSTANNFL 2252
                  13377899999************99999777765568999********9999988889*************************************** PP

      Cullin  392 ryiedKDvFekyYk 405 
                  +yi  K v +++++
  EFC39663.1 2253 DYIVKKGVTKRVFS 2266
                  *****988777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2481 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1626  (0.0906911); expected 358.6 (0.02)
Passed bias filter:                      296  (0.0165096); expected 358.6 (0.02)
Passed Vit filter:                        59  (0.00329076); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.43u 0.34s 00:00:01.77 Elapsed: 00:00:00.59
# Mc/sec: 12654.57
//
Query:       EFC39664.1  [L=665]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.8e-34  117.9   1.0    9.9e-34  116.6   1.0    1.7  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    2.7e-20   72.5   0.0    4.2e-11   42.8   0.0    2.5  2  PAS            PAS fold
    6.4e-15   55.3   1.1      8e-09   35.7   0.1    3.3  3  PAS_9          PAS domain
    4.1e-09   36.7   0.0    0.00015   22.0   0.0    2.3  2  PAS_4          PAS fold
    0.00064   20.3   0.0        2.8    8.6   0.0    3.1  2  PAS_10         PAS domain
     0.0033   17.5   2.7     0.0064   16.6   2.7    1.4  1  DUF4778        Domain of unknown function (DUF4778)
  ------ inclusion threshold ------
      0.032   14.3   0.0       0.12   12.4   0.0    1.9  2  PAS_8          PAS domain
      0.046   14.4   0.2       0.51   11.0   0.0    2.7  3  PAS_2          PAS fold


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  116.6   1.0   4.4e-37   9.9e-34       5     166 ..     436     639 ..     433     662 .. 0.87

  Alignments for each domain:
  == domain 1  score: 116.6 bits;  conditional E-value: 4.4e-37
  Guanylate_cyc   5 sydevtilFadIvgftalssahspievvklLnelyarfdelldekk....vykvktiGdaymvvsglp............................ 68 
                    + +++t++++dIvgft+l++ +sp  vv++L +++++fd+++ +k+    ++k+ktiGd+y v+sgl                             
     EFC39664.1 436 ELQNCTMMYCDIVGFTELANGKSPSIVVHMLHDIFSCFDDIVYSKQhnstLEKIKTIGDCYFVASGLDndsstnnkkqisktnsnvnnmltsptne 531
                    6799*************************************988777899********************************************98 PP

  Guanylate_cyc  69 eekaahaaklaelaLdmlealeevaves.....keglkvrvGihtGp..vvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellk. 156
                     ++++ + ++++ +L m+++le+   ++       +l+vr+Giht    v a v+G  k+ yd++G +v ++  +e+tg++g++++se+  +  k 
     EFC39664.1 532 IPSTNGTMCCVRAGLSMIQELEQLVSKNsdligDSSLQVRIGIHTSHrgVTAAVVGHMKRTYDLFGSDVLVTQLIEATGQPGQVHLSETSFNAIKs 627
                    899999***************6665555355555**********9744499**************************************9999998 PP

  Guanylate_cyc 157 ..eeqfelterg 166
                      + +f +t r 
     EFC39664.1 628 neKLSFLFTPRY 639
                    776677777663 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.2   0.0   1.3e-09     3e-06       2      81 ..     128     207 ..     127     240 .. 0.84
   2 !   42.8   0.0   1.9e-14   4.2e-11       4     112 ..     289     400 ..     286     401 .. 0.89

  Alignments for each domain:
  == domain 1  score: 27.2 bits;  conditional E-value: 1.3e-09
                 HHHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC CS
         PAS   2 dlraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl 81 
                 dl+++++s  +pi+v D +  i y N  aee +G+    v+g+ l++l+++e+  e ++++e  + +++   ++ +s+ +
  EFC39664.1 128 DLVEQFQSCGCPIIVFDSNLTIEYLNNQAEEVFGFYSLAVMGEYLSELLSHESTMEIKRAIEDFIGDTSLDLNMSVSLST 207
                 67889999********************************************9889999988887777777777776666 PP

  == domain 2  score: 42.8 bits;  conditional E-value: 1.9e-14
                 HHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHTT-ECCCCEEEEC....TTSSEEEEEEEEEEEEE CS
         PAS   4 raileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqgeesrageisfkl....rdgrpihlevraspvrd 98 
                 +ai e +  pi+ ++e+g i  +N+a +  +++s +ev+gk++ +l  ++ +   ++ ++++++++ e+r ++  + +    + g+pi++e+r+s ++d
  EFC39664.1 289 EAITEISVIPIISINEQGTIQIFNSASTATFHYSKKEVIGKNVKMLCTPKIRM-NHDDFLKRYLTTGEKRVVDCVRSVkgqtKEGKPIPIELRVSEIID 386
                 5666667789**************************************99886.88888888888888888877666679******************* PP

                 TTEEEEEEEEEEEE CS
         PAS  99 aggeilgflgvlrd 112
                 + ++   f+ ++rd
  EFC39664.1 387 PISKKSSFVAFVRD 400
                 *************9 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.0   2.9e-06    0.0065       3      54 ..     139     188 ..     137     247 .. 0.84
   2 !   35.7   0.1   3.6e-12     8e-09       4     101 ..     299     400 ..     295     403 .. 0.92
   3 ?   -1.4   0.0       1.3   2.8e+03       9      40 ..     510     541 ..     502     569 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 2.9e-06
       PAS_9   3 gilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraal 54 
                 +i++ +++ +i+y N++a++++G+ + +v+g ++++l+  + e+  ++++a+
  EFC39664.1 139 PIIVFDSNLTIEYLNNQAEEVFGFYSLAVMGEYLSELL--SHESTMEIKRAI 188
                 67776699***************99999**********..444444444443 PP

  == domain 2  score: 35.7 bits;  conditional E-value: 3.6e-12
       PAS_9   4 ilidnpdgrilyaNeaalrllGyspeevlgksitdlf..vtdpeanerlraaleqgrk..kerevevvlirkngetfwvlltaspvkdd.dgelvgiiv 97 
                 i+ +n++g+i  +N a    + ys++ev+gk++++l+  +   +++++l+++l +g+k    + + v  ++k+g++++++l++s ++d  +++   +++
  EFC39664.1 299 IISINEQGTIQIFNSASTATFHYSKKEVIGKNVKMLCtpKIRMNHDDFLKRYLTTGEKrvVDCVRSVKGQTKEGKPIPIELRVSEIIDPiSKKSS-FVA 396
                 44478********************************99999999***************99************************999777766.789 PP

       PAS_9  98 ilrD 101
                 ++rD
  EFC39664.1 397 FVRD 400
                 9998 PP

  == domain 3  score: -1.4 bits;  conditional E-value: 1.3
       PAS_9   9 pdgrilyaNeaalrllGyspeevlgksitdlf 40 
                 ++  i + N  ++++l +  +e+  ++ t+++
  EFC39664.1 510 NKKQISKTNSNVNNMLTSPTNEIPSTNGTMCC 541
                 33447799999999998889998888888887 PP

>> PAS_4  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.0   6.8e-08   0.00015       3      57 ..     135     189 ..     133     192 .. 0.91
   2 !   12.3   0.0   6.9e-05      0.16       6      85 ..     297     381 ..     293     402 .. 0.78

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 6.8e-08
       PAS_4   3 slpdalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralr 57 
                 s  ++++v+d++++++y+N++a+e+fg+   +++G+ l ell++e+  ++ ra++
  EFC39664.1 135 SCGCPIIVFDSNLTIEYLNNQAEEVFGFYSLAVMGEYLSELLSHESTMEIKRAIE 189
                 56789****************************************9988888775 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 6.9e-05
       PAS_4   6 dalavldpdgrvlyaNaaaaelfgappeellGktlaellpeedaarleralrrvlegeepi.efleelll....pgeerhyelrl 85 
                  +++ ++++g+++  N a+ + f+++ +e++Gk +  l ++  + ++++ l+r l+++e    ++   +     +g++ ++elr+
  EFC39664.1 297 IPIISINEQGTIQIFNSASTATFHYSKKEVIGKNVKMLCTPKIRMNHDDFLKRYLTTGEKRvVDCVRSVKgqtkEGKPIPIELRV 381
                 589999******************************999999**********999887643033333333566666666666665 PP

>> PAS_10  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0    0.0013       2.8       6      64 ..     134     193 ..     131     227 .. 0.81
   2 !    8.3   0.0    0.0016       3.5      10      79 ..     297     368 ..     289     380 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0013
      PAS_10   6 nstpieltflDdnlqirrFtpaakklfklip.advGrpladihpkkavknveeviealrt 64 
                 +s    ++ +D+nl i + +++a+++f + + a +G+ l+++ ++++  ++++ ie+++ 
  EFC39664.1 134 QSCGCPIIVFDSNLTIEYLNNQAEEVFGFYSlAVMGEYLSELLSHESTMEIKRAIEDFIG 193
                 566778999******************998735679999999888888888888887765 PP

  == domain 2  score: 8.3 bits;  conditional E-value: 0.0016
      PAS_10  10 ieltflDdnlqirrFtpaakklfklipad.vGrpladihpkkavknveevi.ealrtgekdevevvvpkngk 79 
                 i ++ ++++  i  F+ a++  f++ +++ +G +++ + ++k+  n  +++   l tgek +v+ v++++g+
  EFC39664.1 297 IPIISINEQGTIQIFNSASTATFHYSKKEvIGKNVKMLCTPKIRMNHDDFLkRYLTTGEKRVVDCVRSVKGQ 368
                 78999******************99877626******98888888888777256778888888888886665 PP

>> DUF4778  Domain of unknown function (DUF4778)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   2.7   2.9e-06    0.0064     107     289 ..      48     232 ..      26     253 .. 0.81

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 2.9e-06
     DUF4778 107 aahkklfgneslrkreraskkrekgqrkierrlklakragigsesaarqngkRrrkelkekedeekselneiaelldgqdaaervkkeleakslpnseg 205
                 + + kl  n+s    +r  +k +k++ +i ++ ++a+ ++ +s++ + + +  +  e++++e ee+  + +++e ++  + + +  ++ + + +++  +
  EFC39664.1  48 NLQAKLQHNNSRGISSRMLSKLNKTNSTISNSSSIASTSNYSSTYKSSEYSTDSTSEAERNEMEEEAFVITTLEEYSLLNDLVEQFQSCGCPIIVFDSN 146
                 4566777788888888899999999999*********************************88888888777777777776777777777777777777 PP

     DUF4778 206 lgesraslelskrskvrangsaska.lkelsserakelreLirklnervglerdle.kLleAlkkldLedketekdkkekrnkevs 289
                 l+      ++++ ++      + ++ ++ ls+e++ e+++ i++++  + l+ + +  L + +k l++    +++++ke+r+kev 
  EFC39664.1 147 LTIEYLNNQAEEVFGFYSLAVMGEYlSELLSHESTMEIKRAIEDFIGDTSLDLNMSvSLSTSMKDLKIPYVLVSQQEKERRKKEVM 232
                 7777767777777777555555555155689*********************9975489*********999999999999999964 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   5.6e-05      0.12      13      43 ..     139     167 ..     130     190 .. 0.73
   2 ?   -2.9   0.0       3.5   7.8e+03      23      45 ..     308     331 ..     290     348 .. 0.65

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 5.6e-05
       PAS_8  13 giavvdlgdrivdvNqaalellGysadlkge 43 
                 +i+v+d + +i + N++a+e +G+   +++ 
  EFC39664.1 139 PIIVFDSNLTIEYLNNQAEEVFGFY--SLAV 167
                 899***4446*************55..4443 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 3.5
       PAS_8  23 ivdvNqaalellGys.adlkgell 45 
                 i   N a    ++ys ++++g+ +
  EFC39664.1 308 IQIFNSASTATFHYSkKEVIGKNV 331
                 555788888888888888777766 PP

>> PAS_2  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00023      0.51      11      69 ..     132     190 ..     128     220 .. 0.86
   2 ?   -1.6   0.0       1.9   4.2e+03      42      58 ..     311     338 ..     283     379 .. 0.65
   3 ?   -1.6   0.1       1.9   4.3e+03      26      47 ..     512     536 ..     508     583 .. 0.65

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00023
                 EE-TTSEEEEEETTTTEEEEEETTHHHHCSS-CCCCTTTCCCCCSECTTHHHHCCHS-C CS
       PAS_2  11 liQPfGcllavdekslrvlqvSeNaaemLglteekllgtdlralltassaalLekalsa 69 
                 + Q+ Gc + v +++l++  + + a+e+ g+ +   +g+ l++ll+++s++ +++a++ 
  EFC39664.1 132 QFQSCGCPIIVFDSNLTIEYLNNQAEEVFGFYSLAVMGEYLSELLSHESTMEIKRAIED 190
                 56999*************************************************99875 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.9
                 -...........CCCCTTTCCCCCSECT CS
       PAS_2  42 t...........eekllgtdlralltas 58 
                             +++ +g++++ l t++
  EFC39664.1 311 FnsastatfhysKKEVIGKNVKMLCTPK 338
                 3333333333436777899998888876 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 1.9
                 TEEEEEETTHHHHCSS-CCCC...T CS
       PAS_2  26 lrvlqvSeNaaemLglteekl...l 47 
                  ++ +   N+++mL+  +++    +
  EFC39664.1 512 KQISKTNSNVNNMLTSPTNEIpstN 536
                 5677888899999998755444441 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1577  (0.0879581); expected 358.6 (0.02)
Passed bias filter:                      516  (0.0287802); expected 358.6 (0.02)
Passed Vit filter:                        58  (0.00323498); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.75u 0.35s 00:00:01.10 Elapsed: 00:00:00.54
# Mc/sec: 3694.12
//
Query:       EFC39665.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.2e-27   97.1   0.7    6.3e-27   94.7   0.0    2.4  3  DUF2263   Uncharacterized protein conserved in bacteria (DUF2


Domain annotation for each model (and alignments):
>> DUF2263  Uncharacterized protein conserved in bacteria (DUF2263)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.7   0.0   3.5e-31   6.3e-27       3     145 ..      68     238 ..      66     239 .. 0.79
   2 ?   -0.7   0.0     0.094   1.7e+03      42      73 ..     259     290 ..     246     299 .. 0.77
   3 ?   -3.0   0.3      0.47   8.3e+03      99     121 ..     365     387 ..     362     389 .. 0.72

  Alignments for each domain:
  == domain 1  score: 94.7 bits;  conditional E-value: 3.5e-31
                 HHHHHHHHTEEE-TTS-EEE-HHH......HHHHHHT-EEE-H.............................HHHHHHEEES--HHHHHHHHHHH-... CS
     DUF2263   3 etleilekgeylnskgekvdlrea......veaavkgtklysp...................kkaastseeeeeetkievteestleaarrlvkee... 73 
                 +t++i+++++yl + +++ + +++      ve+   +     +                    + +s+ ++ +e+t++ v++ ++++ a ++++e    
  EFC39665.1  68 QTIDICRDQYYLYNFKNHRNSKNRidddeiVEKVSLKE----ElmiqssvgtlfirnegqviPTLNSSDNSIQEKTRVLVINGDCVDVAFKIQDELvks 162
                 56666666666544333333333311112222222222....13333566666666788888678999999*********************9888999 PP

                 ....SS--EEEEE--SSSTTTTGGGT--SHHHHHHHHBSHHHHHTT-HHHHHHHHHH--TT--S-EEEEEEEEEEE CS
     DUF2263  74 ....gekvavLNfASaknpGGGflnGakAQEEsLarsSaLyasllkaeefYeahrakrsplysdamiYSpeVpvfr 145
                     +e+va+LN+A+ + pGGG+++G  AQEE+L+r+S+Ly++l ++ +  ++hr+ ++p+  +++ +Sp+V +fr
  EFC39665.1 163 gkmqNERVAILNMANPNTPGGGYQSGCGAQEENLFRRSNLYQCLDNKVDQLDKHRKWSYPIGHESACFSPNVLFFR 238
                 9***9**********************************************************************9 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.094
                 ........HHHHHHEEES--HHHHHHHHHHH- CS
     DUF2263  42 aastseeeeeetkievteestleaarrlvkee 73 
                 aa+ ++++++++ki  +++ t+ea+ +++  +
  EFC39665.1 259 AAAVPNKSKNTEKIDGRNNGTIEAIFKVAILN 290
                 5667788999999*9*********99987555 PP

  == domain 3  score: -3.0 bits;  conditional E-value: 0.47
                 HHHHHHHHBSHHHHHTT-HHHHH CS
     DUF2263  99 QEEsLarsSaLyasllkaeefYe 121
                 Q E+ +  S +++s  + +++Ye
  EFC39665.1 365 QREEDFTDSQYIYSYENVDDYYE 387
                 54555667888888888888886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       753  (0.041999); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.61u 0.30s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 2301.29
//
Query:       EFC39666.1  [L=398]
Description: 3-phosphoinositide-dependent protein kinase-1 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.2e-65  220.1   0.0    4.4e-65  219.7   0.0    1.2  1  Pkinase         Protein kinase domain
    2.5e-30  105.6   0.0    4.7e-30  104.7   0.0    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
    4.8e-24   84.5   2.4    4.8e-24   84.5   2.4    1.6  2  PH_3            PH domain
     0.0015   18.2   0.8       0.27   10.8   0.4    2.4  2  FTA2            Kinetochore Sim4 complex subunit FTA2
  ------ inclusion threshold ------
       0.06   12.7   0.0       0.11   11.8   0.0    1.4  1  Kinase-like     Kinase-like
       0.08   12.8   0.0        0.2   11.6   0.0    1.6  1  Sushi_2         Beta-2-glycoprotein-1 fifth domain
      0.084   11.6   0.0       0.14   10.9   0.0    1.3  1  Pkinase_fungal  Fungal protein kinase
       0.16   11.9   0.0       0.48   10.3   0.0    1.6  2  APH             Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  219.7   0.0     2e-68   4.4e-65       2     264 .]      10     286 ..       9     286 .. 0.94

  Alignments for each domain:
  == domain 1  score: 219.7 bits;  conditional E-value: 2e-68
                 EEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH.HHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS--HHH CS
     Pkinase   2 ekleklGeGsfGkVykaveketgkivAvKkikkekakkkke.kkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgslseee 99 
                   l++lG+G++++V+  + k++g ++A K+ikk+   k+k+ ++v +E ++l+ l+hpni+ l+ ++++kd+ly+vle+++ggela ++e+ g ls + 
  EFC39666.1  10 DFLKQLGKGAYSEVFLTKYKKSGTHYATKVIKKDFVIKEKKiNTVKMEKEVLNMLSHPNIISLFCTYQDKDHLYFVLELAPGGELAGIIEKYGPLSLDA 108
                 5689******************************9999999899******************************************************* PP

                 HHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS...............BCTTTSCGGGS-HHHHTTSCBSHHHHHHHH CS
     Pkinase 100 akkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssk...............ltsfvgtseYlAPEvlkeneyskkvDvWsl 183
                  ++++++++ gle++Hsk+i+HrDlKpeN++++e+ +lKitDFG ak l+ +++               + +fvgt +Y++PE+lk+ + s+++D+W+l
  EFC39666.1 109 SRFYMAELIMGLEHIHSKNILHRDLKPENLILSEDLHLKITDFGTAKILKLTKPltsdgeefeepvlyvKGTFVGTAHYVSPEILKDLPQSESSDIWAL 207
                 ***************************************************9999*************999**************************** PP

                 HHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTT......HHHHHTSGGG CS
     Pkinase 184 GvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRlt......aeellqhpyl 264
                 G+ily++ltgk++f ge++    + ++++   i+ i   + + ++ ++++++ a d+++++++ + ++Rl+      +++l+qhp++
  EFC39666.1 208 GCILYNFLTGKQLFDGESQ----YLIFQK---ITAIE-REGLIIDDEEDLDPVAVDFIRQVCAFEAENRLGsrqrggMSSLKQHPFF 286
                 ***************3333....334444...44444.457889999***********************99999999999999998 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  104.7   0.0   2.1e-33   4.7e-30       3     223 ..      11     238 ..       9     272 .. 0.78

  Alignments for each domain:
  == domain 1  score: 104.7 bits;  conditional E-value: 2.1e-33
                  EEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr   3 lgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekl 100
                  + k+lG+Ga+++V+  ++k++ ++  +kV+ K +    +e++ + +  e ++++ l+hpni++l   + ++++l++v+e+++gG+L   ++k    +l
   EFC39666.1  11 FLKQLGKGAYSEVFLTKYKKSGTHYATKVIKKDF--VIKEKKINTVKMEKEVLNMLSHPNIISLFCTYQDKDHLYFVLELAPGGELAGIIEKY--GPL 104
                  789****************554444455444444..3455556778889999***************************************98..999 PP

                  BHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEE............EETTSSTSGGGGS-HHHHHHSEEEHHH CS
  Pkinase_Tyr 101 tlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddey............vkkeeaklpvkWmapEslkekkftsks 186
                  +l+    +++++  G+e+++sk+++Hrdl   N +lse+ + ki+DfG a+ ++ ++              ++k++     ++++pE+lk+   +++s
   EFC39666.1 105 SLDASRFYMAELIMGLEHIHSKNILHRDLKPENLILSEDLHLKITDFGTAKILKLTKPLtsdgeefeepvlYVKGTFVGTAHYVSPEILKDLPQSESS 202
                  9999999*****************************************888775444431111112333334555555566788************** PP

                  HHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHHHTTEE CS
  Pkinase_Tyr 187 DvWsfGvllwEiftlgespypglkneevleklkegkr 223
                  D+W+ G +l+  +t g++ + g ++  +++k+++ +r
   EFC39666.1 203 DIWALGCILYNFLT-GKQLFDGESQYLIFQKITAIER 238
                  *************9.**99999999988888865544 PP

>> PH_3  PH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.1       5.6   1.3e+04      17      24 ..      43      50 ..      36      65 .. 0.54
   2 !   84.5   2.4   2.1e-27   4.8e-24       2      76 ..     313     387 ..     312     397 .. 0.95

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 5.6
        PH_3 17 givkKrkg 24
                 +v K+k+
  EFC39666.1 43 DFVIKEKK 50
                33333332 PP

  == domain 2  score: 84.5 bits;  conditional E-value: 2.1e-27
        PH_3   2 rwerfleegelilkqgivkKrkglfarkRqllltdgPrLiyvDpekmekkGeIplskelkvevknskkFlihtpk 76 
                 rw++fl ++e ++++++v Kr+ ++a+kRql+ltd+Pr++y+Dpekm++kG Ip+s+el v  kns++F+i+t +
  EFC39666.1 313 RWSKFLMKNENVVYTALVIKRRRFTAKKRQLILTDKPRILYIDPEKMIVKGIIPWSNELYVVKKNSREFHIQTVE 387
                 8**********************************************************************9965 PP

>> FTA2  Kinetochore Sim4 complex subunit FTA2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.4   0.00012      0.27      21      69 ..       6      55 ..       1      68 [. 0.70
   2 !    5.4   0.0    0.0055        12     178     206 ..     113     141 ..      95     155 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00012
        FTA2 21 ekdiefleyLgkglhsiVlkvkirgk..eYALKlFrfleaeeleeaeedlk 69
                 +d++fl+ Lgkg+ s V+  k++++   YA K+ ++      e++ ++ k
  EFC39666.1  6 REDFDFLKQLGKGAYSEVFLTKYKKSgtHYATKVIKKDFVI-KEKKINTVK 55
                479*************999888887666*****97665332.223333444 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0055
        FTA2 178 lpkllrdlkklhklgIvvrDlkeenyidg 206
                 + +l+  l+ +h+  I++rDlk+en+i +
  EFC39666.1 113 MAELIMGLEHIHSKNILHRDLKPENLILS 141
                 6788899******************9843 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0     5e-05      0.11     144     200 ..     108     163 ..      99     219 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5e-05
  Kinase-like 144 iarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtkvvl 200
                  ++r ++ ++li    ++++k ++h +++++nl+l e+  l++++f+     +   +l
   EFC39666.1 108 ASRFYM-AELIMGLEHIHSKNILHRDLKPENLILSEDLHLKITDFGTAKILKLTKPL 163
                  566777.78888899******************************876555555555 PP

>> Sushi_2  Beta-2-glycoprotein-1 fifth domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   8.8e-05       0.2      13      51 ..      44      85 ..      36      99 .. 0.73

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.8e-05
     Sushi_2 13 vlykgek...vkiedllknrvlHgekvsffCknkekkCsytv 51
                +++k++k   vk+e+ + n+++H +++s+fC  ++k+  y v
  EFC39666.1 44 FVIKEKKintVKMEKEVLNMLSHPNIISLFCTYQDKDHLYFV 85
                34444441226788888999************9999887766 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   6.2e-05      0.14     314     387 ..     115     194 ..     112     214 .. 0.65

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 6.2e-05
  Pkinase_fungal 314 DaIkghrsLflkagiLHrDiSenNilitds.kkegerkglLiDLDlakelsddsses.......garertGTleFmaievlk 387
                     + I g++  +  ++iLHrD   +N+++ ++ + + ++ g    L l k l  d + +       ++++ +GT+ +++ e+lk
      EFC39666.1 115 ELIMGLEHIH-SKNILHRDLKPENLILSEDlHLKITDFGTAKILKLTKPLTSDGE-EfeepvlyVKGTFVGTAHYVSPEILK 194
                     6699999999.****************9663333333333333444444433222.13333333336677777777777776 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.7   3.7e+03       3      31 ..      13      43 ..      12     116 .. 0.63
   2 ?   10.3   0.0   0.00021      0.48     166     197 ..     126     155 ..     118     157 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.7
                EEE--.SSCEEEEEEETT.-.-EEEEEE-TT CS
         APH  3 relsggasnrtylvttpa.g.ryvlrrnppa 31
                ++l+ ga++ ++l + ++ g +y+ +++ + 
  EFC39666.1 13 KQLGKGAYSEVFLTKYKKsGtHYATKVIKKD 43
                6788888888888888887567777775544 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00021
                 EEEE-SS-SGGGEEEC..TTEEEEE---TT-E CS
         APH 166 tvllHgDlhpgNllvdpddgrvtGviDfedag 197
                 + +lH+Dl+p Nl++  +d ++  + Df++a+
  EFC39666.1 126 KNILHRDLKPENLILS-EDLHL-KITDFGTAK 155
                 5689************.66776.799999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (398 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       601  (0.0335211); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2221.31
//
Query:       EFC39667.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.01   16.1   2.2      0.032   14.5   2.2    1.8  2  Med21     Subunit 21 of Mediator complex
      0.018   14.0   0.0      0.045   12.7   0.0    1.5  2  Amidase   Amidase
        1.6    9.4  10.4        5.1    7.8   1.9    3.3  3  SlyX      SlyX
        2.7    8.1   8.5        8.2    6.5   1.3    2.6  2  FlxA      FlxA-like protein


Domain annotation for each model (and alignments):
>> Med21  Subunit 21 of Mediator complex
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.1      0.16   7.3e+02     102     132 ..      44      74 ..      32      83 .. 0.70
   2 ?   14.5   2.2   7.2e-06     0.032      26      90 ..      77     157 ..      50     159 .. 0.69

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.16
       Med21 102 eqeerikeLeeelreveeereekvkekeell 132
                 ++   i eL ++l+++ ++     +e e  l
  EFC39667.1  44 DNSLLISELRKQLENAHHQIVLLQREFEIHL 74 
                 5555688888888888887776666665555 PP

  == domain 2  score: 14.5 bits;  conditional E-value: 7.2e-06
       Med21  26 lntshdpsplseqdpsspsaapalakip.................qeekeepepdspeefaatqrelardlilkeqqIeyLI 90 
                 ++++h+ + l+ +d+++   +  l+ ++                 + +k++ + +s+++ ++ ++el +d+++ +q I +L 
  EFC39667.1  77 VHHQHEIELLK-KDHTIELLQRDLEYHSgirkvattseidqikngDYSKQSDDDNSRTNAKDGIDELTQDIVTLQQHIHKLL 157
                 44444444444.3333333333333333555555666888999987889999999***********************9996 PP

>> Amidase  Amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0     1e-05     0.045      41      90 ..       5      54 ..       2      55 .. 0.93
   2 ?   -1.8   0.0      0.25   1.1e+03     301     340 ..     115     154 ..      83     158 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1e-05
                ......TTTT-EEEEETTB--TTSB--TTSGGGTT-B-SS--HHHHHHHH CS
     Amidase 41 rgkekgpLhGvPisvKDnidvkgvpttaGskalenypaekDatvverLkk 90
                +++++  L+ + +s+K+n+   g++++ +s  l n    +++ +++ L+k
  EFC39667.1  5 TKEQDETLTNCCFSIKENYPMMGMQSSVSSIELLNDSLADNSLLISELRK 54
                4688999*****************************************98 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.25
                 TT-SSSSS---SS-SCCCCCCCHHHHCCS-HHHHHHHHHH CS
     Amidase 301 arylgvryerlsetkvlsellpksraellgeevkrrielg 340
                  +  +++y + s++++ ++  +  ++el +++v+ + + +
  EFC39667.1 115 DQIKNGDYSKQSDDDNSRTNAKDGIDELTQDIVTLQQHIH 154
                 3445566677777777788888888888888888777665 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   1.9    0.0011       5.1      18      52 ..      34      68 ..      31      82 .. 0.86
   2 ?    1.2   0.2      0.13   5.9e+02      26      40 ..      85      99 ..      71     117 .. 0.66
   3 ?    4.6   0.2     0.011        50      17      36 ..     137     156 ..     133     159 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0011
                HHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXX CS
        SlyX 18 tieeLndvvaeqqqqidrlqrqlrllaerlkelee 52
                 ie Lnd +a+    i++l++ql+  + ++  l+ 
  EFC39667.1 34 SIELLNDSLADNSLLISELRKQLENAHHQIVLLQR 68
                5899*******************999998866555 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.13
                HHHHHHHHHHHHHHH CS
        SlyX 26 vaeqqqqidrlqrql 40
                + + +++i+ lqr l
  EFC39667.1 85 LLKKDHTIELLQRDL 99
                333444455555544 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.011
                 HHHHHHHHHHHHHHHHHHHH CS
        SlyX  17 dtieeLndvvaeqqqqidrl 36 
                 d i+eL + ++  qq i +l
  EFC39667.1 137 DGIDELTQDIVTLQQHIHKL 156
                 77999999999999999998 PP

>> FlxA  FlxA-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.6   1.0    0.0035        16      16      38 ..      46      68 ..      29      99 .. 0.77
   2 ?    6.5   1.3    0.0018       8.2       4      37 ..     124     157 ..     110     160 .] 0.77

  Alignments for each domain:
  == domain 1  score: 5.6 bits;  conditional E-value: 0.0035
        FlxA 16 asqiasLqkQiknlqkqLkelse 38
                +  i++L+kQ++n+  q+  l+ 
  EFC39667.1 46 SLLISELRKQLENAHHQIVLLQR 68
                4458999******9999987765 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0018
        FlxA   4 ssasssssssgsasqiasLqkQiknlqkqLkels 37 
                  ++ + +s ++ ++ i +L++ i +lq+ + +l 
  EFC39667.1 124 KQSDDDNSRTNAKDGIDELTQDIVTLQQHIHKLL 157
                 4566677777778888888888888888888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1328  (0.0740699); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.54u 0.33s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 944.65
//
Query:       EFC39668.1  [L=840]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.7e-05   23.5  11.8    0.00041   20.2   0.3    2.8  2  zf-CCCH    Zinc finger C-x8-C-x5-C-x3-H type (and similar)
     0.0045   16.7  12.0       0.28   11.0   5.5    2.5  2  zf-CCCH_4  CCCH-type zinc finger
  ------ inclusion threshold ------
        2.6    8.2  12.0        2.2    8.4   1.2    3.1  2  zf_CCCH_4  Zinc finger domain
        5.9    6.3   4.9        5.4    6.4   0.7    2.1  2  DUF2868    Protein of unknown function (DUF2868)


Domain annotation for each model (and alignments):
>> zf-CCCH  Zinc finger C-x8-C-x5-C-x3-H type (and similar)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.1   5.8    0.0024        11       5      19 ..     482     495 ..     480     504 .. 0.78
   2 !   20.2   0.3   9.2e-08   0.00041       1      25 [.     543     567 ..     543     569 .. 0.96

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0024
                 CBCHHHHHS--TTGG CS
     zf-CCCH   5 lCrffmrtGyCkyGd 19 
                 +Cr++++ G Ck+G+
  EFC39668.1 482 PCRDHFK-GKCKFGS 495
                 8******.******7 PP

  == domain 2  score: 20.2 bits;  conditional E-value: 9.2e-08
                 -HCHCBCHHHHHS--TTGGG-SSBS CS
     zf-CCCH   1 yktelCrffmrtGyCkyGdrCkFaH 25 
                 +kte C+ ++   +C  G +CkF H
  EFC39668.1 543 KKTEVCMKHSSIQSCGNGKNCKFLH 567
                 69*********************** PP

>> zf-CCCH_4  CCCH-type zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.0   5.5   6.3e-05      0.28       1      22 []     481     503 ..     481     503 .. 0.97
   2 !    9.3   0.5   0.00022         1      10      21 ..     556     567 ..     554     567 .. 0.95

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 6.3e-05
   zf-CCCH_4   1 rlCpyfakGsCrfGd.nCrFsHd 22 
                 ++C+  +kG+C+fG+  C +sHd
  EFC39668.1 481 KPCRDHFKGKCKFGSgICPYSHD 503
                 79********************9 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00022
   zf-CCCH_4  10 sCrfGdnCrFsH 21 
                 sC  G nC+F+H
  EFC39668.1 556 SCGNGKNCKFLH 567
                 799********* PP

>> zf_CCCH_4  Zinc finger domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   3.8     0.023     1e+02       1      13 [.     483     495 ..     483     502 .. 0.85
   2 ?    8.4   1.2    0.0005       2.2       8      19 .]     556     567 ..     551     567 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.023
   zf_CCCH_4   1 CkfflqGtCkkGd 13 
                 C+   +G+Ck+G+
  EFC39668.1 483 CRDHFKGKCKFGS 495
                 99999*******8 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0005
   zf_CCCH_4   8 tCkkGdkCrFaH 19 
                 +C +G +C+F+H
  EFC39668.1 556 SCGNGKNCKFLH 567
                 7*********** PP

>> DUF2868  Protein of unknown function (DUF2868)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.2     0.042   1.9e+02     177     226 ..     273     354 ..     233     396 .. 0.56
   2 ?    6.4   0.7    0.0012       5.4     177     253 ..     434     516 ..     409     518 .. 0.71

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.042
     DUF2868 177 a.......................aapePeaapepkaeaepepasep.........advlelelderlaelelraglgvrva 226
                 +                       a+++Pe++p  ++ ++++++++          +++ +le +e+ ++++l+++l+ +++
  EFC39668.1 273 NigggnnlvgfnttgnnglgnkesAKKKPEPQPVSQKSKSKKKNDKAkaaqevkplVETPKLEKEEKSEQEKLDEELAKKLQ 354
                 4555555555555555566666555555555555555444444444466777777733333333333334444444333333 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0012
     DUF2868 177 a.....aapePeaapepkaeaepepasepadvlelelderlaelelraglgvrvaasaadgGrld.drearsrvlaslaesap 253
                 +     ++++ e++p+pk+e +++p +e+++ +e++ + +++e+  ++  +   + ++++g +++   ++rs  +++++e+++
  EFC39668.1 434 NskknkNKKKNEPTPQPKKEEKEKPEPEKVEKVETKTKTEAKEEGYNKPCRDHFKGKCKFGSGICpYSHDRSFYIKYQQEHPD 516
                 03333456777777777777777777777777777777777766777777777999999*99999888889999999999864 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (840 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2713  (0.151319); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                       111  (0.00619109); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.09u 0.35s 00:00:01.44 Elapsed: 00:00:00.56
# Mc/sec: 4532.46
//
Query:       EFC39669.1  [L=773]
Description: Ku70/Ku80 beta-barrel domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.2e-43  148.4   0.1    4.7e-43  147.3   0.1    1.6  1  Ku          Ku70/Ku80 beta-barrel domain
    2.1e-41  140.8   2.9    5.5e-41  139.5   2.9    1.8  1  Ku_PK_bind  Ku C terminal domain like
    1.6e-15   57.5   0.3    1.6e-15   57.5   0.3    2.4  3  Ku_N        Ku70/Ku80 N-terminal alpha/beta domain
    2.6e-06   28.0   0.2    1.5e-05   25.6   0.2    2.4  1  Ku_C        Ku70/Ku80 C-terminal arm


Domain annotation for each model (and alignments):
>> Ku  Ku70/Ku80 beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  147.3   0.1   1.1e-46   4.7e-43       1     203 [.     245     443 ..     245     444 .. 0.91

  Alignments for each domain:
  == domain 1  score: 147.3 bits;  conditional E-value: 1.1e-46
          Ku   1 igggvsipVklykateeakkpkfkk...ldketne....pvkvetkyvcsdt.ge.vdeedivkgyeyGgevvpltkeelekiksfdskglkllgFvpl 90 
                 i+g+++ipV++yk+te+++ p+ k    ++++ n+     v++e+ y++ d+ ++ ++++++vk+y+yG+++vp++    + +k   skg+++lgF+++
  EFC39669.1 245 IAGNIKIPVWVYKKTEKTSLPTAKRlslVSRRANTggdgDVQMERCYYSYDDpDNqIEKDKTVKAYKYGKNFVPFNIVNEKALKYKSSKGITVLGFTDE 343
                 6799****************99999665666666699**99**********99899*********************9999666633************ PP

          Ku  91 seilkeylsikssyfiyPddkdekgstkafsaLveamleskkvaivrfvlrskskprlvaLvPqeeelsseeekeglvlvtLpfaddiRslkfpsldee 189
                 ++i++++++  ++y ++++ +d  ++  a+s++++a+ e+++v+i ++v+r++ +p+l+ L+P+   +  ++  e+l+++ Lpfa+diR+++f s+   
  EFC39669.1 344 KNIDRSHFMA-ETYSFIAKPDDPFAQI-ALSSFIRALSELEMVMIITYVYRDDLEPKLGFLYPH---IGTNS--ECLYFNALPFAEDIREYPFKSF--- 432
                 ********88.8888888899999999.************************************...65554..7*********************... PP

          Ku 190 eeekknkpteeqld 203
                    ++ k +eeql+
  EFC39669.1 433 ---STVKHSEEQLQ 443
                 ...78899999997 PP

>> Ku_PK_bind  Ku C terminal domain like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.5   2.9   1.2e-44   5.5e-41       1     119 [.     630     745 ..     630     746 .. 0.98

  Alignments for each domain:
  == domain 1  score: 139.5 bits;  conditional E-value: 1.2e-44
  Ku_PK_bind   1 dPvedFkkllaqkdeedlvekavkqlksvIeqlvedslgdssydkaveclkalReeaieeeepelyNdFlrdlkkklqseggdrrefWkelvkkeklgl 99 
                 +P +dF ++l++kd  d v+ka+++++ vI++lv+ds++d++y+k+++c+k+lRe++i+e ep+++N+Fl++lk++++ + g+r++fW +++++++++l
  EFC39669.1 630 NPTKDFSEMLNRKDV-DMVDKAIQEMQVVIFKLVNDSIEDQYYEKVLACIKTLREGCIREAEPNQFNNFLKKLKQSYS-K-GKREDFWCSFIVQNNISL 725
                 79************9.9************************************************************9.5.9***************** PP

  Ku_PK_bind 100 IskdeaessdvteeeAkeFl 119
                 I++de+++s+vte+eAk+Fl
  EFC39669.1 726 ITQDECDESEVTEDEAKKFL 745
                 *******************9 PP

>> Ku_N  Ku70/Ku80 N-terminal alpha/beta domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.5   0.3   3.6e-19   1.6e-15       2     168 ..      15     175 ..      14     187 .. 0.87
   2 ?   -2.0   0.1      0.53   2.4e+03      83     118 ..     648     683 ..     607     691 .. 0.65
   3 ?   -2.1   0.2       0.6   2.7e+03      22      44 ..     737     760 ..     717     761 .. 0.73

  Alignments for each domain:
  == domain 1  score: 57.5 bits;  conditional E-value: 3.6e-19
                 EEEEEE-SHHHHCTTCCSCCHHHHHHHHHHHHHHHHHHCTCSEEEEEEEESSSSTBS......TTTCTTEEEEEECCCHHHHHHHHHHCCHHHCCHHHH CS
        Ku_N   2 vvfviDvspaMfesskeeespfelalkciaellkrkvisrskDlIavvlygtdesen......keqlenitvlreldlpdaellkelkqivesedasve 94 
                 +v++ Dv+++    s++e   fe a+  i+ l+k k+  ++kD++++vl+gt++++n      + ++eni+  + +d+ + +l k  ++i  +      
  EFC39669.1  15 LVIIFDVGKSLGTRSRDE---FEKAKRAITLLIKMKMRYSPKDEVGFVLVGTKKTKNhlndeyEGEYENIYIEQAIDTVSLDLFKIVDSINID------ 104
                 778888888887776664...669**************************************99******************99999999999...... PP

                 CCCTTSS-TTHHHHHHHHHHHHHH.TTSSESEEEEEEEESSSSTCC..GHHHHHHHHHHHHHHHHHHCTEEEEEEEC CS
        Ku_N  95 glaedssqasllsaLivclellqk.vgkklskkriflftdlddpfe..dsdklelilqklkakDlrderieldllkL 168
                  +++ s +++l +a+iv+ +++++ +gk+   kri++++d     +  d+d  e i q       r+++++++++ L
  EFC39669.1 105 -TIGMSPEGDLFDAVIVATDMIKDrCGKRKYAKRIVIVSDAGGTEIsvDNDTRENIYQG-----MRNQDVKVNVIGL 175
                 .9***********************99*999*********9999886666666666666.....6666666666655 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.53
                 HCCHHHCCHHHHCCCTTSS-TTHHHHHHHHHHHHHH CS
        Ku_N  83 kqivesedasveglaedssqasllsaLivclellqk 118
                 ++ +++ +   ++l++ds + + ++ +++c++ l++
  EFC39669.1 648 DKAIQEMQVVIFKLVNDSIEDQYYEKVLACIKTLRE 683
                 334444444667777777777777777777777776 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.6
                 HHHHHHHHHHHHHHHHHHCTCS.E CS
        Ku_N  22 pfelalkciaellkrkvisrsk.D 44 
                   ++a+k ++e++++ vi++++ D
  EFC39669.1 737 TEDEAKKFLTEAVIAAVIQEESeD 760
                 447899999999999999987655 PP

>> Ku_C  Ku70/Ku80 C-terminal arm
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.2   3.2e-09   1.5e-05       2      72 ..     469     550 ..     468     559 .. 0.78

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 3.2e-09
                 --GGG---HHHHHHHHHHHHHHTT---.............---SS--HH..HHHHHHH-....HHHHHHHHHHHHH..HHHHH. CS
        Ku_C   2 ydpskfpNPsLqrhykiLqalAldedlpe...........eledktlpk..yeaidkragslleewkelfeleeedkekkkekr 72 
                 ++p ++ NP +q++y +L+ +Al +++p+            +e +      y ++ ++ +++  ++k lf+++e ++++k  kr
  EFC39669.1 469 MKPTCIYNPLVQHFYDCLHVRALKPNDPLppveplitkfcYPEMNP--EsfYYKLMEKTKEHRLKFKSLFPTKEVEADSKLGKR 550
                 79***************************77777776544222222..255677778888999999999999999887555554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (773 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       853  (0.0475766); expected 358.6 (0.02)
Passed bias filter:                      488  (0.0272185); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.53
# Mc/sec: 4428.76
//
Query:       EFC39670.1  [L=333]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.019   15.1   0.0      0.042   14.0   0.0    1.6  1  DUF3105   Protein of unknown function (DUF3105)


Domain annotation for each model (and alignments):
>> DUF3105  Protein of unknown function (DUF3105)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   2.3e-06     0.042      35      72 ..      45      82 ..      29     121 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 2.3e-06
     DUF3105 35 pvpnenaVHnLehGavvllYdpklpaeqvekLkklvka 72
                ++p+   V+ Le G++ ++Y+pk+ +e v++L+++ k 
  EFC39670.1 45 QQPQHINVKLLEFGHIYFFYKPKVMQEHVNNLDQVQKL 82
                667778899***********************999883 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (333 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       864  (0.0481901); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 1998.29
//
Query:       EFC39671.1  [L=140]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.5e-09   37.2   4.8    4.3e-05   23.8   0.7    3.1  3  LRR_4     Leucine Rich repeats (2 copies)
    4.2e-09   36.0   2.7     0.0004   20.1   0.0    2.5  2  LRR_8     Leucine rich repeat
      6e-08   32.1   1.9      0.033   14.2   0.0    4.2  4  LRR_6     Leucine Rich repeat
    0.00035   20.7   3.7        3.5    8.5   0.0    4.2  3  LRR_1     Leucine Rich Repeat
  ------ inclusion threshold ------
      0.079   12.5   0.5      0.093   12.3   0.5    1.2  1  cobW      CobW/HypB/UreG, nucleotide-binding domain


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.8   0.7   1.2e-08   4.3e-05       2      39 ..      46      84 ..      45      88 .. 0.82
   2 !   11.5   0.4   8.6e-05      0.31       3      36 ..      90     124 ..      77     128 .. 0.67
   3 !   13.4   0.1   2.2e-05      0.08       2      27 ..     113     140 .]     112     140 .] 0.85

  Alignments for each domain:
  == domain 1  score: 23.8 bits;  conditional E-value: 1.2e-08
                S--EEE--SS---E-S-HHH-TT--EEE-.-S.-----G CS
       LRR_4  2 nLevLdLsnNqltdiplleklpnLkeLdLsgN.nlitdl 39
                nLe+L++s N +++ ++l+kl +Lk+L +s N  +i+++
  EFC39671.1 46 NLEHLSISCNSIRKGEFLQKLEQLKSLRMSMNcMNIESI 84
                9*******99******************96652344555 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 8.6e-05
                 --EEE--..SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   3 LevLdLs..nNqltdiplleklpnLkeLdLsgNnli 36 
                 L+ Ld    + ++   + +++l +L++L++s+N  i
  EFC39671.1  90 LTCLDVEecGINVDRASTISQLEQLRYLNVSNN-EI 124
                 555555522223344444668*********666.55 PP

  == domain 3  score: 13.4 bits;  conditional E-value: 2.2e-05
                 S--EEE--SS---E-S-...HHH-TT--E CS
       LRR_4   2 nLevLdLsnNqltdipl...leklpnLke 27 
                 +L++L+ snN +  i++   ++k++nL++
  EFC39671.1 113 QLRYLNVSNNEIG-IEGmrlISKMKNLET 140
                 79***********.888885447****96 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.7   2.7e-06    0.0098      21      59 ..      41      77 ..      35      79 .. 0.88
   2 !   20.1   0.0   1.1e-07    0.0004       2      52 ..      89     139 ..      88     140 .] 0.91

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 2.7e-06
                STT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8 21 FkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59
                 +++ nL++L++s+N+++  +   ++ L++L+sL +s N
  EFC39671.1 41 LERMINLEHLSISCNSIRKGE--FLQKLEQLKSLRMSMN 77
                67899*************985..99********999977 PP

  == domain 2  score: 20.1 bits;  conditional E-value: 1.1e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-. CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLr 52 
                 +Lt Ld+    +++ + ++ ++l++L++L+ snN++     + +s +++L+
  EFC39671.1  89 QLTCLDVEECGINVDRASTISQLEQLRYLNVSNNEIGIEGMRLISKMKNLE 139
                 7999********************************998888888888886 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.6   0.1    0.0013       4.5       4      15 ..      46      57 ..      44      59 .. 0.89
   2 ?    3.8   0.0      0.02        73       5      15 ..      69      79 ..      65      85 .. 0.87
   3 ?    3.1   0.0     0.035   1.3e+02       5      16 ..      90     101 ..      87     103 .. 0.88
   4 !   14.2   0.0   9.2e-06     0.033       5      23 ..     114     132 ..     110     133 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0013
       LRR_6  4 hLteLdLsgNdI 15
                +L++L++s+N I
  EFC39671.1 46 NLEHLSISCNSI 57
                8*********98 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.02
       LRR_6  5 LteLdLsgNdI 15
                L++L +s N++
  EFC39671.1 69 LKSLRMSMNCM 79
                9********96 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.035
       LRR_6   5 LteLdLsgNdIg 16 
                 Lt Ld+  ++I+
  EFC39671.1  90 LTCLDVEECGIN 101
                 9********996 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 9.2e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++L++s N+Ig eG+  +
  EFC39671.1 114 LRYLNVSNNEIGIEGMRLI 132
                 9**************9877 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.2    0.0016       5.8       1      12 [.      46      57 ..      46      67 .. 0.83
   2 ?    2.4   0.1       0.1   3.7e+02       2      12 ..      69      79 ..      68     111 .. 0.65
   3 !    8.5   0.0   0.00098       3.5       1      12 [.     113     124 ..     113     135 .. 0.80

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0016
       LRR_1  1 nLrhLdLsnnpl 12
                nL+hL +s n++
  EFC39671.1 46 NLEHLSISCNSI 57
                8*********98 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.1
       LRR_1  2 LrhLdLsnnpl 12
                L++L +s n+ 
  EFC39671.1 69 LKSLRMSMNCM 79
                77777777773 PP

  == domain 3  score: 8.5 bits;  conditional E-value: 0.00098
       LRR_1   1 nLrhLdLsnnpl 12 
                 +Lr+L++snn +
  EFC39671.1 113 QLRYLNVSNNEI 124
                 59********98 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.5   2.6e-05     0.093      31      99 ..      22      90 ..       9     127 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.6e-05
                EEESS-SSCHCCCCCCHCCCT.EEEETTTTECCH..CTT-HHHHHHHHHHHHTT-SEEEEEECTTTTHHHH CS
        cobW 31 vivNefgevsiDaellretgveivelenGciCct..lredllkelealeereerldviliEttGlaePapv 99
                +i ++f +  iD+el  ++ + +++le   i c+   + ++l++le+l++++ +++++ iE+  +  P+++
  EFC39671.1 22 IIDGDFDQPLIDGELFLDCLERMINLEHLSISCNsiRKGEFLQKLEQLKSLRMSMNCMNIES--IKLPKQL 90
                7899***************999***********985678*************6666666665..3333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (140 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       414  (0.0230911); expected 358.6 (0.02)
Passed bias filter:                      277  (0.0154498); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 851.61
//
Query:       EFC39672.1  [L=5213]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.8e-90  296.9 642.0    0.00013   22.2   8.0   40.5 40  EGF_2     EGF-like domain


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   7.3   2.6e-07    0.0046       5      32 .]      86     112 ..      81     112 .. 0.91
   2 !   12.7   6.6     7e-06      0.13       7      32 .]     136     164 ..     131     164 .. 0.84
   3 !   14.4  10.3   2.1e-06     0.038       4      32 .]     175     203 ..     169     203 .. 0.89
   4 !    8.6   7.2   0.00013       2.4       7      32 .]    2148    2174 ..    2144    2174 .. 0.77
   5 !   16.4  12.2   4.8e-07    0.0087       6      32 .]    2184    2210 ..    2179    2210 .. 0.90
   6 !   17.1  11.4   2.9e-07    0.0052       5      32 .]    2223    2249 ..    2219    2249 .. 0.91
   7 !    9.5   8.5   7.1e-05       1.3       5      32 .]    2263    2289 ..    2259    2289 .. 0.87
   8 !   12.2   8.8   9.9e-06      0.18       5      32 .]    2302    2328 ..    2298    2328 .. 0.86
   9 !   12.8   6.1   6.6e-06      0.12       5      32 .]    2341    2367 ..    2337    2367 .. 0.87
  10 !   19.8   8.0   4.2e-08   0.00076       5      32 .]    2380    2406 ..    2376    2406 .. 0.91
  11 !    6.7  10.7   0.00054       9.6       5      32 .]    2419    2445 ..    2411    2445 .. 0.89
  12 !   14.9   5.0   1.5e-06     0.026       5      32 .]    2458    2484 ..    2454    2484 .. 0.86
  13 !    8.6  12.1   0.00014       2.5       4      32 .]    2495    2523 ..    2493    2523 .. 0.88
  14 !   13.0  13.3   5.8e-06       0.1       3      32 .]    2755    2783 ..    2753    2783 .. 0.87
  15 !   22.2   8.0   7.4e-09   0.00013       4      32 .]    2795    2823 ..    2793    2823 .. 0.88
  16 !   14.4   8.1   2.1e-06     0.037       6      32 .]    2838    2863 ..    2833    2863 .. 0.90
  17 !   14.1   6.5   2.6e-06     0.046       6      32 .]    2877    2902 ..    2873    2902 .. 0.89
  18 !   14.3  13.0   2.3e-06     0.041       5      32 .]    2915    2941 ..    2907    2941 .. 0.85
  19 !   17.9   8.6   1.7e-07     0.003       5      32 .]    2954    2980 ..    2950    2980 .. 0.89
  20 !   12.8   8.7   6.4e-06      0.11       6      32 .]    2994    3019 ..    2990    3019 .. 0.90
  21 !    6.9  10.7   0.00045       8.1       5      32 .]    3032    3058 ..    3029    3058 .. 0.90
  22 !   10.1   6.2   4.4e-05      0.79       7      32 .]    3073    3097 ..    3068    3097 .. 0.91
  23 !   14.7   9.2   1.6e-06     0.029       5      32 .]    3110    3136 ..    3106    3136 .. 0.92
  24 !   19.6   7.9   4.8e-08   0.00086       6      32 .]    3150    3175 ..    3146    3175 .. 0.92
  25 !   20.6  11.6   2.4e-08   0.00043       5      32 .]    3188    3214 ..    3185    3214 .. 0.91
  26 !   17.9   5.2   1.7e-07     0.003       6      32 .]    3228    3253 ..    3224    3253 .. 0.90
  27 !   20.1   5.8   3.5e-08   0.00062       5      32 .]    3266    3292 ..    3262    3292 .. 0.91
  28 !   18.3   8.4   1.3e-07    0.0023       5      32 .]    3305    3331 ..    3301    3331 .. 0.84
  29 !   15.5  11.5   9.1e-07     0.016       4      32 .]    3342    3370 ..    3340    3370 .. 0.89
  30 !   10.3   8.8     4e-05      0.73       5      32 .]    3383    3409 ..    3379    3409 .. 0.90
  31 !    8.6   5.4   0.00013       2.4       5      32 .]    3422    3448 ..    3418    3448 .. 0.85
  32 !   16.1   9.3   5.9e-07     0.011       6      32 .]    3462    3487 ..    3457    3487 .. 0.91
  33 !   14.0   9.1   2.7e-06     0.048       4      32 .]    3498    3526 ..    3492    3526 .. 0.89
  34 !   16.2  12.4   5.6e-07      0.01       4      32 .]    3537    3565 ..    3531    3565 .. 0.87
  35 !   17.6   3.1     2e-07    0.0036       7      32 .]    3580    3604 ..    3576    3604 .. 0.94
  36 !   12.1   7.3   1.1e-05       0.2       5      32 .]    3617    3643 ..    3609    3643 .. 0.90
  37 !   15.1   9.6   1.2e-06     0.022       5      32 .]    3656    3682 ..    3648    3682 .. 0.88
  38 !    4.7   7.2    0.0022        39       1      28 [.    3737    3760 ..    3737    3769 .. 0.78
  39 ?   -1.0   1.3      0.14   2.5e+03      23      32 .]    3772    3781 ..    3765    3781 .. 0.87
  40 !    6.0   3.7    0.0009        16      18      32 .]    4473    4487 ..    4465    4487 .. 0.82

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 2.6e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                  +iC+g+G C n + +C+C+ g++G  C
  EFC39672.1  86 INICSGRGNCTNDT-ECECQLGFYGEEC 112
                 589*******9899.9***********9 PP

  == domain 2  score: 12.7 bits;  conditional E-value: 7e-06
       EGF_2   7 iCgghGtCvnqcGq...CdCdsgyqGktC 32 
                 +C+ghG C  + ++   C C+ +++G +C
  EFC39672.1 136 TCSGHGNCSWLSNEtssCTCEEQFFGTHC 164
                 7*******866663455************ PP

  == domain 3  score: 14.4 bits;  conditional E-value: 2.1e-06
       EGF_2   4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + +++C+g GtCv+++  C C +gy+G  C
  EFC39672.1 175 NsSSTCSGYGTCVDFN-TCNCTDGYTGLAC 203
                 24899********999.9*********999 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.00013
       EGF_2    7 iCgghGtCvnqcGqCdCds..gyqGktC 32  
                   C+ +G+C++++ +C+C+s  gy G  C
  EFC39672.1 2148 VCNERGKCISSN-NCSCNStlGYGGSEC 2174
                  7********888.8***76336666666 PP

  == domain 5  score: 16.4 bits;  conditional E-value: 4.8e-07
       EGF_2    6 eiCgg.hGtCvnqcGqCdCdsgyqGktC 32  
                   +C+g +GtC++++  C+C+ gy+Gk+C
  EFC39672.1 2184 GECHGeRGTCIAPE-TCQCKEGYYGKYC 2210
                  68************.9************ PP

  == domain 6  score: 17.1 bits;  conditional E-value: 2.9e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g G+C++++ +C+C++gy+G  C
  EFC39672.1 2223 SLVCKGFGQCNDFN-NCSCQPGYSGSEC 2249
                  789********999.8************ PP

  == domain 7  score: 9.5 bits;  conditional E-value: 7.1e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+g+G C ++   C+C+ +y G  C
  EFC39672.1 2263 SFVCSGRGNCSQKD-SCSCFEHYIGYEC 2289
                  678********777.6*********999 PP

  == domain 8  score: 12.2 bits;  conditional E-value: 9.9e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                   + C+g G+C +    C C+s+y+G  C
  EFC39672.1 2302 TNVCNGYGSCTAND-MCNCSSNYFGEFC 2328
                  679*******9555.8***********9 PP

  == domain 9  score: 12.8 bits;  conditional E-value: 6.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +e C+ +G+C  ++ +C+C+ +y+G  C
  EFC39672.1 2341 SEVCHRRGICWPFN-NCSCEEHYYGQEC 2367
                  789*******7567.8***********9 PP

  == domain 10  score: 19.8 bits;  conditional E-value: 4.2e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG+C +++ +C C+++y+G++C
  EFC39672.1 2380 SLVCSTHGKCSSFE-NCTCSDKYYGNHC 2406
                  789***********.8************ PP

  == domain 11  score: 6.7 bits;  conditional E-value: 0.00054
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ghG+C ++   C+C +++ G +C
  EFC39672.1 2419 SSVCSGHGSCTSPD-TCQCGANRLGLNC 2445
                  689********999.9******999999 PP

  == domain 12  score: 14.9 bits;  conditional E-value: 1.5e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hGtC +  + C+C+ +y G+ C
  EFC39672.1 2458 SSVCSSHGTCTDY-NICKCFLNYDGPFC 2484
                  578*******744.48***********9 PP

  == domain 13  score: 8.6 bits;  conditional E-value: 0.00014
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+g+G+Cv+++  C+C + + G +C
  EFC39672.1 2495 NdSNVCSGNGKCVDFN-SCQCGNRFGGENC 2523
                  34899********999.7***999999999 PP

  == domain 14  score: 13.0 bits;  conditional E-value: 5.8e-06
       EGF_2    3 asdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +++++C+g+G+C++ +  C+C+ g +G +C
  EFC39672.1 2755 NDNSTCSGNGQCIDYN-SCKCNYGAYGTDC 2783
                  3489********9555.7************ PP

  == domain 15  score: 22.2 bits;  conditional E-value: 7.4e-09
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +  C+g+G+C++ + +C+C+sgy+G +C
  EFC39672.1 2795 NeSFVCSGRGSCIANE-VCECNSGYFGEYC 2823
                  45678********777.9************ PP

  == domain 16  score: 14.4 bits;  conditional E-value: 2.1e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C+g+G+C ++   C+C+ gy+G +C
  EFC39672.1 2838 FVCSGQGSCTSPD-TCKCNIGYSGMDC 2863
                  57********999.9***********9 PP

  == domain 17  score: 14.1 bits;  conditional E-value: 2.6e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ hG+C+++   C+C++gy G  C
  EFC39672.1 2877 TVCNSHGSCIAPD-TCFCKTGYLGQWC 2902
                  67********999.9*********987 PP

  == domain 18  score: 14.3 bits;  conditional E-value: 2.3e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+g+G+C++ + +C+C+  y+G tC
  EFC39672.1 2915 KYVCSGRGSCISYN-NCQCNHTYYGSTC 2941
                  789*******9555.8************ PP

  == domain 19  score: 17.9 bits;  conditional E-value: 1.7e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +C+g+GtCv+    C+C+++y+G++C
  EFC39672.1 2954 NKTCSGRGTCVDID-TCVCSNNYYGNNC 2980
                  679*******9666.8************ PP

  == domain 20  score: 12.8 bits;  conditional E-value: 6.4e-06
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ +GtCv ++  C+C ++y G +C
  EFC39672.1 2994 SVCSSRGTCVGFN-TCSCLNNYMGSQC 3019
                  68********777.9************ PP

  == domain 21  score: 6.9 bits;  conditional E-value: 0.00045
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g G+C +++ +C+C +g +G +C
  EFC39672.1 3032 SSVCSGKGICGEFN-NCSCLQGNFGQNC 3058
                  678*******9899.8***********9 PP

  == domain 22  score: 10.1 bits;  conditional E-value: 4.4e-05
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C g GtCv++   C C+s+  G  C
  EFC39672.1 3073 VCTGYGTCVDTD-TCACSSNSLGSRC 3097
                  6*******9777.9**********99 PP

  == domain 23  score: 14.7 bits;  conditional E-value: 1.6e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG C +++  C C+++y+G  C
  EFC39672.1 3110 SLVCSSHGNCTSPN-TCTCQDHYSGSRC 3136
                  678********999.9***********9 PP

  == domain 24  score: 19.6 bits;  conditional E-value: 4.8e-08
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ hG+C +++ +C C+++y+G tC
  EFC39672.1 3150 SVCNSHGYCSSFN-NCICSANYYGSTC 3175
                  57********999.8************ PP

  == domain 25  score: 20.6 bits;  conditional E-value: 2.4e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hGtC n++ +C C+sgy+G +C
  EFC39672.1 3188 SSVCSSHGTCSNFN-NCTCKSGYSGSKC 3214
                  789********999.8************ PP

  == domain 26  score: 17.9 bits;  conditional E-value: 1.7e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                    C+g+GtC++ +  C+C   y+Gk+C
  EFC39672.1 3228 KVCSGRGTCIDIE-TCSCLKDYFGKHC 3253
                  57*******9778.8************ PP

  == domain 27  score: 20.1 bits;  conditional E-value: 3.5e-08
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG+C+++  +C+C+++y+G +C
  EFC39672.1 3266 SSVCSSHGQCISAD-KCSCSAHYFGTNC 3292
                  689********999.************* PP

  == domain 28  score: 18.3 bits;  conditional E-value: 1.3e-07
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+ hG+C +  + C+C+sgy+G +C
  EFC39672.1 3305 SYVCSAHGSCKDY-NLCECKSGYYGSNC 3331
                  789*******744.48************ PP

  == domain 29  score: 15.5 bits;  conditional E-value: 9.1e-07
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+ghG+C +++  C C+ g +G++C
  EFC39672.1 3342 NqSSVCSGHGSCTDSN-TCICNHGSYGDNC 3370
                  56789*******8788.9************ PP

  == domain 30  score: 10.3 bits;  conditional E-value: 4e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ hG C ++  +C C+ +y+G +C
  EFC39672.1 3383 SSVCSYHGPCHSPD-NCTCNEKYTGRNC 3409
                  789*******9999.8************ PP

  == domain 31  score: 8.6 bits;  conditional E-value: 0.00013
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  +  C+  G C +   +C+C+s y G+ C
  EFC39672.1 3422 SKVCNSVGNCSKVD-ECHCPSEYAGPWC 3448
                  778*******9666.8*********988 PP

  == domain 32  score: 16.1 bits;  conditional E-value: 5.9e-07
       EGF_2    6 eiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + C+ +G C +++  C+C+s+y+G +C
  EFC39672.1 3462 NVCNSRGNCSTLN-HCSCNSSYTGSNC 3487
                  68********788.9************ PP

  == domain 33  score: 14.0 bits;  conditional E-value: 2.7e-06
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + ++ C+ +G+Cv++  qC+C  +y+G +C
  EFC39672.1 3498 NsSSVCNSRGKCVEFD-QCECAENYFGMNC 3526
                  35899********999.**********999 PP

  == domain 34  score: 16.2 bits;  conditional E-value: 5.6e-07
       EGF_2    4 s.deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  + +e+C g+G+C +    C+C+ gy+G++C
  EFC39672.1 3537 NsSETCTGRGSCTSHD-TCVCNKGYSGPDC 3565
                  3589********8666.8************ PP

  == domain 35  score: 17.6 bits;  conditional E-value: 2e-07
       EGF_2    7 iCgghGtCvnqcGqCdCdsgyqGktC 32  
                   C+++G+C ++   C+C+++ +G +C
  EFC39672.1 3580 VCSQRGVCSDLD-TCECEPNSFGSDC 3604
                  6*******9999.9************ PP

  == domain 36  score: 12.1 bits;  conditional E-value: 1.1e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+ +G C++++  CdC+  y+G++C
  EFC39672.1 3617 SLVCQSRGRCESFN-HCDCNLPYFGPNC 3643
                  689********999.9************ PP

  == domain 37  score: 15.1 bits;  conditional E-value: 1.2e-06
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C ++   C+C++gy G +C
  EFC39672.1 3656 ELVCSGNGQCTDFD-TCKCKDGYLGFNC 3682
                  789*******9999.9*********999 PP

  == domain 38  score: 4.7 bits;  conditional E-value: 0.0022
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyq 28  
                  C ++   C ++G C +    C+C s++ 
  EFC39672.1 3737 CANN---CFNNGECKSDL-TCKCYSSFE 3760
                  8877...*******7666.6***88875 PP

  == domain 39  score: -1.0 bits;  conditional E-value: 0.14
       EGF_2   23 CdsgyqGktC 32  
                  C +gy+G +C
  EFC39672.1 3772 CLNGYYGINC 3781
                  99*******9 PP

  == domain 40  score: 6.0 bits;  conditional E-value: 0.0009
       EGF_2   18 cGqCdCdsgyqGktC 32  
                   G+C+C +gy G +C
  EFC39672.1 4473 SGECKCADGYIGTHC 4487
                  369************ PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (5213 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2223  (0.123989); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        83  (0.00462937); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 2.29u 0.34s 00:00:02.63 Elapsed: 00:00:00.68
# Mc/sec: 23210.88
//
Query:       EFC39673.1  [L=822]
Description: acyl-CoA dehydrogenase family member [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      7e-36  124.3   0.0    1.3e-35  123.4   0.0    1.4  1  APH             Phosphotransferase enzyme family
    5.1e-34  117.6   4.0    8.3e-34  117.0   4.0    1.3  1  Acyl-CoA_dh_1   Acyl-CoA dehydrogenase, C-terminal domain
    7.7e-17   61.3   0.0    2.2e-16   59.8   0.0    1.9  1  Acyl-CoA_dh_M   Acyl-CoA dehydrogenase, middle domain
    2.1e-12   47.4   3.9    1.4e-11   44.8   4.1    2.1  2  Acyl-CoA_dh_2   Acyl-CoA dehydrogenase, C-terminal domain
    3.1e-12   47.2   0.0    6.5e-12   46.1   0.0    1.6  1  Acyl-CoA_dh_N   Acyl-CoA dehydrogenase, N-terminal domain
    1.1e-06   28.2   0.2    2.5e-06   27.0   0.2    1.5  1  EcKinase        Ecdysteroid kinase
     0.0037   16.9   0.2     0.0085   15.7   0.2    1.5  1  Choline_kinase  Choline/ethanolamine kinase


Domain annotation for each model (and alignments):
>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  123.4   0.0   5.2e-39   1.3e-35       2     215 ..      35     303 ..      34     311 .. 0.89

  Alignments for each domain:
  == domain 1  score: 123.4 bits;  conditional E-value: 5.2e-39
                 EEEE--.SSCEEEEEE...........ETT-.......-EEEEEE-TT...S-HHHHHHHHHHHHHHHHTT-B--B-CTTBS-EEETTEEEEEEE---- CS
         APH   2 vrelsggasnrtylvt...........tpag.......ryvlrrnppa...raaeeirrevallrlLakagvpvPevlagdtddeeigllfalieyvpg 79 
                 + ++s+g+sn++++v+           +  +       ++vlr +pp+    +a +i re+a+++ L+  g+pvP ++ ++   e+ig++f+l+e+v g
  EFC39673.1  35 IVQFSDGQSNPSFKVViqlaptttsskD--QqqqvntiELVLRKKPPGkllPSAHDIYREYAIMKSLHSIGFPVPNMYLYCRETEVIGTEFYLMEFVRG 131
                 67899***********999998876541..14567789**********77777888889999************************************* PP

                 EE-SS.....................HHHHHHHHHHHHHHHHHHCCHHCH.-STTTB-................SHHCHTCCHHHHHHCHHHCCCGCCT CS
         APH  80 rsllr.....................klsaaqlpellealgeflaalhqvdpaalpla................dflaqdlellrqlesatarllasel 141
                 r++ +                     +l+a++++e+  +++ +l +lh+v  +++ ++                   ++  + +rq+  +t++++ase+
  EFC39673.1 132 RIFKDatftqmhkvvgggvsdakgpdQLTADDRREMMIDFVKTLSRLHSV--NFRDFEllnglykqaasslnnnNGQKKENYYERQITTWTRQYVASET 228
                 **************************9***********************..44444455677766666666665556778888*************** PP

                 CCHHHHHHHHHHHHHHHH--S...SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-EEEECCHHHHCCHHHCSCH CS
         APH 142 ldlleeleeqvlaalaallpg...elptvllHgDlhpgNllvdpddgrvtGviDfedaglgpplyDlavllrswtse 215
                 ++  e + + ++ +l+++ p     ++ +++HgD++ +N++++p+++rv++v+D+e+++lg+p++Dla+ ++++  +
  EFC39673.1 229 HE-NETMNR-LIKWLPQNIPQetlTESSCITHGDYKFDNVIFHPTENRVIAVLDWELSTLGHPIADLAYSCMYYHFP 303
                 **.888888.*************************************************************776554 PP

>> Acyl-CoA_dh_1  Acyl-CoA dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.0   4.0   3.2e-37   8.3e-34       1     148 [.     656     817 ..     656     819 .. 0.95

  Alignments for each domain:
  == domain 1  score: 117.0 bits;  conditional E-value: 3.2e-37
                    TBHHHHHTTTT--S-----..-SHHHHHHHHHHHHHHHTSB-CC-BGGGSHHHHHHHHHHHHHHHHHHHHHHHHHH--------..HHHHHHHHHH CS
  Acyl-CoA_dh_1   1 gkGfrvametlnheRlavaaaalglarraleealeyarrrkafgkplidhqlvreklaemaaeleaarllvyraaealdagkpd..raeasmaKlf 94 
                    g+Gf++a+ +l  +R+ +a++++gla+r +e+++++a+ rk+fgk+l +h ++++ ++e ++++e+arllv++aa+++d+ + +  rae++m+K+ 
     EFC39673.1 656 GQGFNIAQARLGPGRIHHAMRMIGLAERTFEQMVRRAKARKTFGKTLSQHAIIQQYIGESRIDIEQARLLVLKAAYMIDKVGAKhaRAEIAMIKIA 751
                    79******************************************************************************999889********** PP

                    HHHHHHHHHHHHHHHHGGGTT..........SGGGH..HHHHHHHTHHHHHSSS-HHHHHHHHHHH CS
  Acyl-CoA_dh_1  95 aselaqevadlamqllGgaGy..........leeyp..verlyrdarvlrigeGtseiqrniiarr 148
                    ++++  +vad+a+q++G++G+           ee +  ++r +  ar l++++G++e+++  +a++
     EFC39673.1 752 VPRATKRVADRAIQVFGAEGLmtspadytspIEESAfsIARVWIGARQLQLADGPDEVHLINLAKQ 817
                    *********************99999999984444455**********************999986 PP

>> Acyl-CoA_dh_M  Acyl-CoA dehydrogenase, middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.8   0.0   8.5e-20   2.2e-16       1      92 [.     540     637 ..     540     644 .. 0.83

  Alignments for each domain:
  == domain 1  score: 59.8 bits;  conditional E-value: 8.5e-20
                    EEE---.SS-SS-GGG---EE.EEETT.EEEEEEEEEEEETTTT-SEEEEEEE.TS---...----EEEEEEE..GGGEEE-----BSS-TTS-EE CS
  Acyl-CoA_dh_M   1 afalTE.pqaGsdvasvktta.aerdggeyvlnGeKiwitnaaiatlalvlar.tekpd...rarglslflvprdapgvsvrrieeklGlrglptg 90 
                    +f +TE  ++ sd+++v++t  +++dg++y++nG K++it+a++  + +++++ +++p+    +++ s++l+p dapgv+++r   + Gl+++p+g
     EFC39673.1 540 CFSMTEyNNSSSDATNVRSTIkKTQDGKHYIINGVKWFITGAGDKRCKFTIFMgQTNPEhpsVHHRQSMVLIPLDAPGVKLERAAITFGLDDAPSG 635
                    9*****5555***********88899999***************66666666653444456789999**************99999********88 PP

                    EE CS
  Acyl-CoA_dh_M  91 el 92 
                    + 
     EFC39673.1 636 HW 637
                    74 PP

>> Acyl-CoA_dh_2  Acyl-CoA dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.59   1.5e+03     104     131 ..     118     145 ..     115     147 .. 0.82
   2 !   44.8   4.1   5.3e-15   1.4e-11       3     112 ..     673     774 ..     671     777 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.59
                    HCGGGGGBTT-HHHHHHHHHHHHCTSGG CS
  Acyl-CoA_dh_2 104 aaGgsalrkesplqRlwRDahaaaaHaa 131
                    ++G+  +++e +  R++ Da+ +++H +
     EFC39673.1 118 VIGTEFYLMEFVRGRIFKDATFTQMHKV 145
                    66777777777888************86 PP

  == domain 2  score: 44.8 bits;  conditional E-value: 5.3e-15
                    HHHHHHHHHHHHHHHHHHHHHHHHCTTT-------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHHHHHHHHHH CS
  Acyl-CoA_dh_2   3 iaavalGaAraalaefvelarervrassgekladdpatqlalaeaaarldAAralleraaaraealaaagkevtvedraearraaalavelaiaav 98 
                    +a+ ++G+A+++++++v +a++r++  +g++l+++ ++q+ ++e++ ++++Ar+l+++aa+ + ++   g++     rae+++ ++++ + + +++
     EFC39673.1 673 HAMRMIGLAERTFEQMVRRAKARKT--FGKTLSQHAIIQQYIGESRIDIEQARLLVLKAAYMIDKV---GAK---HARAEIAMIKIAVPRATKRVA 760
                    7999*********************..***********************************5543...333...3589***************** PP

                    HHHHHHCGGGGGBT CS
  Acyl-CoA_dh_2  99 dalfeaaGgsalrk 112
                    d++++++G+ +l +
     EFC39673.1 761 DRAIQVFGAEGLMT 774
                    ***********975 PP

>> Acyl-CoA_dh_N  Acyl-CoA dehydrogenase, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.1   0.0   2.5e-15   6.5e-12       6     112 ..     418     535 ..     413     536 .. 0.81

  Alignments for each domain:
  == domain 1  score: 46.1 bits;  conditional E-value: 2.5e-15
                    HHHHHHHHHHHHHTHH.......HHHHHHHHTS.......GH...HHHHHHHHHTTCTSTTS-GGGTS--S-HHHHHHHHHHHHHH-HHHHH.HHH CS
  Acyl-CoA_dh_N   6 alrdtvrefaeeelap.......haaewdeege.......fp...relwkklaelGllgitvpeeygGagldyleaaivaeelaradaglal.llg 83 
                     l++++ +f++e++ p       ++       +       +p   +el +k+++ Gl++  +   +    l+++e+a++ae ++r  ++ ++   +
     EFC39673.1 418 RLKEKLEKFMNEHIYPgekifenQI-------HemkdkwdTPpilEELKEKAKKEGLWNFFLVHHHPTEHLTNVEYAVLAEIMGRSFIAPEVfNCN 506
                    5788999999999999333322223.......1233333433355899*****************99999***************99998887888 PP

                    HHHHTTHHHHHHHS-HHHHHHHHHHHHTT CS
  Acyl-CoA_dh_N  84 vhsslvapailrfGteeqkrryLpklasg 112
                    + ++ +++++++fGt+eqk++yL++l++g
     EFC39673.1 507 APDTGNMEVLMKFGTPEQKEKYLKPLLDG 535
                    899999*********************99 PP

>> EcKinase  Ecdysteroid kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.0   0.2   9.7e-10   2.5e-06     139     260 ..     190     296 ..     164     303 .. 0.65

  Alignments for each domain:
  == domain 1  score: 27.0 bits;  conditional E-value: 9.7e-10
    EcKinase 139 pevfkelkkglleedyvssalkeafeelleellkaalealreelpelekeaekleklkenlferllelve.....ekeeefnvlnHGDlwvnNimfkyd 232
                 +                   +k+a ++l ++  ++  +++++++ +++++  + e  +++ ++rl + +      e+ +e + ++HGD+   N++f+ +
  EFC39673.1 190 NG-----------------LYKQAASSLNNNNGQKKENYYERQITTWTRQYVASETHENETMNRLIKWLPqnipqETLTESSCITHGDYKFDNVIFHPT 271
                 33.................33344444444444444455555555554444444444444444444444334444779999***************999 PP

    EcKinase 233 eegepedvilvDFQlsrygSpalDLlyf 260
                 e+     +  +D+ ls +g p+ DL+y+
  EFC39673.1 272 ENR---VIAVLDWELSTLGHPIADLAYS 296
                 884...78899***************97 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.7   0.2   3.3e-06    0.0085      67     185 ..     167     295 ..     155     308 .. 0.63

  Alignments for each domain:
  == domain 1  score: 15.7 bits;  conditional E-value: 3.3e-06
                     HHHHHHHHHHHHTTCHH.TTSSSS-HHHHHHHHHHHCCS.TT..ECHHGGCCHCCCTHHHHHHH......HHTHHHHH.H.....CHGG-EEEE- CS
  Choline_kinase  67 iskkiAkklaelHsleleseskespslwktmqkwllnkeaqtkakkekkkkqlklinledleke......leklekll.e.....elespvvfcH 149
                     ++    k l +lHs+++ +  +  + l+k+  +    ++++ ++k++ ++ q+++++ + + +e      +++l k+l +      l ++    H
      EFC39673.1 167 MMIDFVKTLSRLHSVNF-RDFELLNGLYKQAASS--LNNNNGQKKENYYERQITTWTRQYVASEthenetMNRLIKWLpQnipqeTLTESSCITH 258
                     66677899999999999.5666666667766666..3333333344444444444433333322000001344444443344443444557889* PP

                     S--SGGGEEE.-CTTEEE.E--GTT-EEEEHHHHHHH CS
  Choline_kinase 150 nDlqegNillnkeekklv.lIDFEYagynyrgfDlan 185
                      D    N++++ +e++++ + D+E ++      Dla 
      EFC39673.1 259 GDYKFDNVIFHPTENRVIaVLDWELSTLGHPIADLAY 295
                     **********88877765278*********9999995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (822 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       787  (0.0438954); expected 358.6 (0.02)
Passed bias filter:                      582  (0.0324614); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.78u 0.33s 00:00:01.11 Elapsed: 00:00:00.50
# Mc/sec: 4914.13
//
Query:       EFC39674.1  [L=2320]
Description: dedicator of cytokinesis 4 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.2e-24   84.0  27.1    5.3e-23   81.5  27.1    2.3  1  DHR-2     Dock homology region 2
    2.4e-05   24.2   1.4    2.4e-05   24.2   1.4    3.1  3  DOCK-C2   C2 domain in Dock180 and Zizimin proteins
     0.0071   16.4   0.7      0.064   13.4   0.7    2.7  1  SEA       SEA domain


Domain annotation for each model (and alignments):
>> DHR-2  Dock homology region 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.5  27.1   8.8e-27   5.3e-23      42     521 ..    1826    2305 ..    1777    2311 .. 0.80

  Alignments for each domain:
  == domain 1  score: 81.5 bits;  conditional E-value: 8.8e-27
       DHR-2   42 lktinsyaksdkelkessfpeqvkellkrlrtvlkatvkmkeekedpemladlq......yslansyk..sspdlritwLeslaekhaenenfsEaa 130 
                   + + ++        e +f+++++ l++ l+ +lk+   ++ ++++   +++ q       +  +s+k  s+ +l+ ++L+ la+++++++ ++Ea 
  EFC39674.1 1826 KELMVELLG---PEAEDEFANKMDVLMESLHHLLKQIRDIEAASTNDPNTMNFQnqeksfKNALKSFKknSNVQLYFKYLHLLASMQKSRKRYIEAG 1919
                  333333332...23344788888888888888888888887444443444544445666656667777544489*********************** PP

       DHR-2  131 qclihaaaLiaeylkllkkipkklgasaFekispnvlkeesesasalkedsgvcdseefteeglvellekaiellkkgelyElaielyklliplyek 227 
                   + +++a+++         ++++++++ F+   p+   e+   ++++k                ++l++++i+l++kg+ +E ai+l+++l  +y++
  EFC39674.1 1920 LAIFQHAQMLN--------FNSNIELPLFSDNYPE---EP---ECTRK----------------IKLYKEVIDLFEKGKDWERAISLNEELRVIYKN 1986
                  *******9998........3355678888877774...33...23444................59******************************* PP

       DHR-2  228 krdykklseihkklaelyekivetsksekRlfgtYyRVgFyGkkFeeldgkeyvYkepkltrLseiserlksqysekfgeekveiikdskpvdksel 324 
                  k++y +ls +h++ ++ly+kiv+    + R   +Yy VgFyGk   ++++  +++  +  ++L+++ + +k +++ +  + ++    d++++  +  
  EFC39674.1 1987 KMNYAELSVVHSEESKLYKKIVT----SIREYNKYYFVGFYGK---SMSNTNFIFNAH-HQKLADFVNFIKLKFKGATIKREIPSSFDETKF--R-- 2071
                  ***********************....89*************9...799******876.589*********999999997666655555555..3.. PP

       DHR-2  325 dpdkaYiqitaVePyfeeeelk....................erktsFernnnvnrFvfetP...Ftksgkkaqg.......sleeqwkrrtiLtte 391 
                   ++ + i    VeP  + +e++                     +++++++ +n++ F   +     t+++ ++ g       s+ +q     ++ ++
  EFC39674.1 2072 TSEQQVIFLAPVEPSSQ-QEINsfmdettgedsfklldptisPKIQQYHKSHNIKVFKRVKVkreQTEEKSASAGnmdepkqSMDDQDGSIFFFAIK 2167
                  44555666678999655.4553366889999***********9************997655522255555455559****988************** PP

       DHR-2  392 nsfPylkkRlevvskeeielsPievaieeiekkteeleaaikae.....ppnlktLqmlLqGsvavqVNaGpleiaeaFLsee...kakelpaekve 480 
                  + fP++ +  ev +k+ ++l+ +evai  +e ++ ++++++ ++     +  + +L   L G ++  + +G+ +  e +Ls+e   + +e ++  +e
  EFC39674.1 2168 KPFPNMYTIQEVREKKLFKLNSLEVAIYYLELRIHAVQELVVSHklnesNLLTASLDSELTGLIDPRIHGGIYKDVERYLSPEaleNLTEENQLLIE 2264
                  ***************************************99986455445667889999************************7765555678899* PP

       DHR-2  481 kLkeafreflkvckeaLelnkklikedqrelqeeLeegfek 521 
                  k k  +++++  +ke+L   +k +++++ ++   Le++f++
  EFC39674.1 2265 KYKTRLSQLAYQLKEGLTQRRKHVSKQNLQMSVYLEKKFKN 2305
                  ***************************************86 PP

>> DOCK-C2  C2 domain in Dock180 and Zizimin proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.2   1.4   4.1e-09   2.4e-05       3     193 ..     977    1143 ..     975    1145 .. 0.74
   2 ?   -1.8   0.1      0.38   2.3e+03      86     127 ..    1851    1909 ..    1836    1957 .. 0.67
   3 ?   -3.6   0.0       1.3     8e+03      19      42 ..    2283    2306 ..    2276    2311 .. 0.73

  Alignments for each domain:
  == domain 1  score: 24.2 bits;  conditional E-value: 4.1e-09
     DOCK-C2    3 dvrNdlYvtlksgefsskgskssakniqvtvevrdsdgerlekaiylgsgeelvsefrsvvlyhnkqptfneeiKialpieltekhHLlFtfrhvsc 99  
                  d+rNd+Y+++k++  +    + ++  ++ +++++ +dg ++ ++ +    +  ++ +rs+++ + k+p+++e++ +++  ++ +++ ++F+f+ v++
  EFC39674.1  977 DIRNDIYINVKNVLNK----NVKTLFVEAKMYIKGKDGMTI-QCDI----NRKQRVYRSAIV-RMKNPSWSEILLVNVNSHQLQSAIIVFEFYVVNT 1063
                  89**********9874....345677888899999999888.6666....345788888885.56*******************************9 PP

     DOCK-C2  100 eekkkekdkeeeekpfgyaflpLlkedgraflkd....gehelpvykkelppsgYlslpssrtssseeqkgpsekwldnskdtfkvrtklcSTiltq 192 
                  ++      ++ e +p  +a++   +  g+  l+     +   lp y    ++ g+ ++ + +++++ +q   +     ++ +++ + ++++ST    
  EFC39674.1 1064 KK------NAYEISPDFFAYFHVDD--GTRTLTLgnetQIDPLPCYD--FTK-GFTNIHEFDQNEPIKQ---KC----QKNAKLCLAVNVVSTSIAI 1142
                  42......33456788888888864..55445532244667799998..667.9998876654444444...23....3778899999999997765 PP

     DOCK-C2  193 d 193 
                  +
  EFC39674.1 1143 N 1143
                  5 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.38
     DOCK-C2   86 ekhHLlFtfrhvsceekkk.................ekdkeeeekpfgyaflpLlkedg 127 
                  + hHLl  +r++ + + ++                 +++k++++  + + +l Ll + +
  EFC39674.1 1851 SLHHLLKQIRDIEAASTNDpntmnfqnqeksfknalKSFKKNSNVQLYFKYLHLLASMQ 1909
                  55889999999887544448877776666666666655555556666677776666444 PP

  == domain 3  score: -3.6 bits;  conditional E-value: 1.3
     DOCK-C2   19 skgskssakniqvtvevrdsdger 42  
                  ++++  s++n+q++v++ ++ ++ 
  EFC39674.1 2283 QRRKHVSKQNLQMSVYLEKKFKND 2306
                  466788999******999886654 PP

>> SEA  SEA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.7   1.1e-05     0.064      18      60 ..    1867    1909 ..    1859    1918 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.1e-05
         SEA   18 ladpsSaefkslardieelldevfqksslkkqyigsevlrlrp 60  
                   +dp++++f++ +++++++l+ + ++s+++ +++  ++l+  +
  EFC39674.1 1867 TNDPNTMNFQNQEKSFKNALKSFKKNSNVQLYFKYLHLLASMQ 1909
                  589**********************************987755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2320 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1059  (0.0590663); expected 358.6 (0.02)
Passed bias filter:                      376  (0.0209716); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.13u 0.35s 00:00:01.48 Elapsed: 00:00:00.52
# Mc/sec: 13377.28
//
Query:       EFC39675.1  [L=1692]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.7e-53  179.5   0.1    1.4e-52  178.0   0.1    1.9  1  Guanylate_cyc  Adenylate and Guanylate cyclase catalytic doma
    4.9e-12   46.0   1.2    2.1e-11   44.0   0.2    2.7  3  PAS_9          PAS domain
    2.9e-05   24.0   0.0    5.9e-05   23.0   0.0    1.6  1  PAS            PAS fold
     0.0066   15.9   0.2     0.0066   15.9   0.2    2.1  2  HNOBA          Heme NO binding associated
  ------ inclusion threshold ------
      0.013   16.1   0.1      0.058   14.0   0.0    2.1  2  PAS_10         PAS domain
      0.058   13.6   0.9         25    5.2   0.2    4.0  3  zf-AD          Zinc-finger associated domain (zf-AD)
       0.33   10.8   2.7         12    5.8   0.3    2.8  2  TIM21          TIM21


Domain annotation for each model (and alignments):
>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  178.0   0.1   5.5e-56   1.4e-52       3     182 ..    1494    1677 ..    1492    1678 .. 0.96

  Alignments for each domain:
  == domain 1  score: 178.0 bits;  conditional E-value: 5.5e-56
  Guanylate_cyc    3 aesydevtilFadIvgftalssahspievvklLnelyarfdelldekkvykvktiGdaymvvsglp.eekaahaaklaelaLdmlealeevave 95  
                     ae++d++t +F+d+vgft++ss  +p ++v +Ln++++ fd l+d+++++k+ktiGday +v g++ +ek +h ++ +++a+d+++ +++ ++e
     EFC39675.1 1494 AEKFDDMTCFFSDMVGFTKMSSTLNPTQLVGMLNNVVNGFDALIDKHNLEKIKTIGDAYFCVGGIKlSEKDDHPERTLKFAIDVFQVVRSYNEE 1587
                     6899*************************************************************9999*******************999988 PP

  Guanylate_cyc   96 s....keglkvrvGihtGpvvagviGakkprydvwGntvnlAsrmestgkagkiqvseetyellkeeqfeltergevevkGkgkletyfle 182 
                     +     +++++r+G++tG+ vagviG+kk+ yd+wG++vn+Asrmest+ +g+iq+s +tye  k+ +fe++er +vevkGkg   ty+l+
     EFC39675.1 1588 HrlefGHQINIRIGLNTGESVAGVIGTKKFAYDLWGDAVNTASRMESTSLSGRIQISLSTYERVKHIGFEFEER-SVEVKGKGLCNTYLLS 1677
                     867666*****************************************************************998.69***********985 PP

>> PAS_9  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       2.2   5.5e+03      78     102 ..      66      90 ..      39      92 .. 0.81
   2 ?   -3.3   0.0       4.4   1.1e+04      16      40 ..     640     666 ..     635     696 .. 0.55
   3 !   44.0   0.2   8.2e-15   2.1e-11       2     103 ..    1349    1454 ..    1348    1455 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.2
       PAS_9  78 vlltaspvkdddgelvgiivilrDi 102
                   +t s ++++++ ++ +i+ ++D 
  EFC39675.1  66 SSITSSIMRNGQQAIFTFISSMKDR 90 
                 5688899999999999999999996 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 4.4
       PAS_9  16 aNeaalrllG.ys.peevlgksitdlf 40 
                 +N+++lr++  y  +  +      +++
  EFC39675.1 640 MNKSFLRIYArYLeEVKFDSETANEFY 666
                 799999997754313334444455555 PP

  == domain 3  score: 44.0 bits;  conditional E-value: 8.2e-15
       PAS_9    2 dgilidnpdgrilyaNeaalrllGyspeevlgksitdlfvtdpeanerlraaleqgrk........kerevevvlirkngetfwvlltaspvkdddg 90  
                  dg +++n+ ++i+ +N+aa +++  +  + lg+s+t lf  d +++++l++++ ++ +        + ++v++++ rkn+++f+++++++    d++
  EFC39675.1 1349 DGAVLCNSACEIEIFNPAAQKMFNCKQSDTLGTSLTSLF--DRNNRDELSRLISELIQstlttkesQGETVDLDCLRKNQTKFPAKVNLFSTLFDNK 1443
                  788999*********************************..999999999999999999999***************************99988899 PP

       PAS_9   91 elvgiivilrDit 103 
                   ++   ++++D+t
  EFC39675.1 1444 PVIT--CFIKDVT 1454
                  9999..******9 PP

>> PAS  PAS fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   2.3e-08   5.9e-05       3     113 .]    1340    1453 ..    1338    1453 .. 0.85

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 2.3e-08
                  HHHHHHHSSSEEEEEETTSBEEEECHHHHHHHSSTHHHCTTSBGGGGBSTTHHHHHHHHHHHHHHHT.T-ECCCCEEEEC....TTSSEEEEEEEEE CS
         PAS    3 lraileslpdpifvvDedgrilyvNaaaeellGlsreevlgkslldliheeddaelaelleqlleqg.eesrageisfkl....rdgrpihlevras 94  
                  +r+il+s  d+ ++ +   +i  +N+aa+++++ ++++ lg sl  l+  + ++el +l+++l++++ + ++++  +++l    ++++++++ v+  
  EFC39675.1 1340 VRNILNSVVDGAVLCNSACEIEIFNPAAQKMFNCKQSDTLGTSLTSLFDRNNRDELSRLISELIQSTlTTKESQGETVDLdclrKNQTKFPAKVNLF 1436
                  799*********************************************9999999999999999753244444444444455999999999999999 PP

                  EEEETTEEEEEEEEEEEES CS
         PAS   95 pvrdaggeilgflgvlrdi 113 
                  ++++  +    + ++++d+
  EFC39675.1 1437 STLFDNKP--VITCFIKDV 1453
                  98888776..899999886 PP

>> HNOBA  Heme NO binding associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   2.3       2.7     7e+03     163     210 ..     815     861 ..     810     863 .. 0.83
   2 !   15.9   0.2   2.6e-06    0.0066     193     221 .]    1458    1486 ..    1452    1486 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 2.7
       HNOBA 163 srelvlagiqqsaelelaldqleeksaeLeesmkeleeekkrtdeLLy 210
                  +++vl+  q +++++l++  l +  +e+  s+++ ++  +++ eLL 
  EFC39675.1 815 NQQIVLQMSQSQNSVSLQK-ALPQIYHEMVLSLEQSDQSVEKITELLK 861
                 6788888888888888888.8899999999999999999999998886 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 2.6e-06
       HNOBA  193 esmkeleeekkrtdeLLysmiPkevAerL 221 
                  ++++ l eekk++++LL s++P++vA+rL
  EFC39675.1 1458 KQLALLAEEKKKSENLLRSILPESVASRL 1486
                  677889*********************98 PP

>> PAS_10  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       3.3   8.4e+03      36      67 ..    1014    1045 ..    1009    1065 .. 0.61
   2 ?   14.0   0.0   2.3e-05     0.058       2      70 ..    1341    1410 ..    1340    1426 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 3.3
      PAS_10   36 padvGrpladihpkkavknveeviealrtgek 67  
                   +++Gr+l++  ++ +++ + ++  +l +   
  EFC39675.1 1014 FSQIGRTLKTYEKNIKKELISNIYTELGKYTH 1045
                  57999999999877666666666666655444 PP

  == domain 2  score: 14.0 bits;  conditional E-value: 2.3e-05
      PAS_10    2 nnlLnstpieltflDdnlqirrFtpaakklfklipad.vGrpladihpkkavknveeviealrtgekdev 70  
                   n+Lns+  + +  ++  +i  F+paa+k+f+ +++d +G +l+++  +++ +++ ++i +l+++   ++
  EFC39675.1 1341 RNILNSVVDGAVLCNSACEIEIFNPAAQKMFNCKQSDtLGTSLTSLFDRNNRDELSRLISELIQSTLTTK 1410
                  5999*****************************998857*******999999999999988887765444 PP

>> zf-AD  Zinc-finger associated domain (zf-AD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.0     0.045   1.1e+02      45      75 ..    1184    1214 ..    1171    1215 .. 0.89
   2 ?    5.2   0.2    0.0096        25      11      55 ..    1381    1424 ..    1373    1427 .. 0.88
   3 ?   -0.1   0.0      0.45   1.2e+03      13      46 ..    1533    1568 ..    1526    1570 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.045
       zf-AD   45 pekiCesCleklqefyeFrekcveanellqe 75  
                   +k Ce+C +      eF+ +cv+ ne l++
  EFC39675.1 1184 TTKACENCSSLESIVDEFVVSCVKLNEDLMK 1214
                  5679*********************999875 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0096
       zf-AD   11 eellsifdtsnssislaeileeltglelepddslpekiCesClek 55  
                   +l s+fd++n++ +l+++++el + +l++++s +e++  +Cl+k
  EFC39675.1 1381 TSLTSLFDRNNRD-ELSRLISELIQSTLTTKESQGETVDLDCLRK 1424
                  57899******99.***************9999999888888765 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.45
       zf-AD   13 llsifdtsnss..islaeileeltglelepddslpe 46  
                  ++ + d+ n +  +++ + + ++ g++l+++d+ pe
  EFC39675.1 1533 FDALIDKHNLEkiKTIGDAYFCVGGIKLSEKDDHPE 1568
                  56667777777789***************9998876 PP

>> TIM21  TIM21
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.3    0.0045        12       4      37 ..     983    1016 ..     978    1030 .. 0.83
   2 ?    4.0   0.1     0.016        42       8      42 ..    1254    1289 ..    1249    1304 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0045
                  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXT CS
       TIM21    4 eatkntlsliivlagvgvtglvlYlilselfsps 37  
                   +t++ l++ + ++gv v+++v +l+ + +f ++
  EFC39675.1  983 TFTNDYLYFFVSIGGVYVICAVSFLLYMKIFFSQ 1016
                  5678899**********************98764 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.016
                  XXXXXXXXXXXXXXXXXX.XXXXXXXXXXXTHHHHH CS
       TIM21    8 ntlsliivlagvgvtglv.lYlilselfspsgdtki 42  
                   ++s++iv + +g +++v ++l+l+++f + ++++ 
  EFC39675.1 1254 PSVSMVIVFGVLGAICIVsIFLMLRSIFKSHSKNTE 1289
                  456777777777887776589**********99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1692 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1739  (0.0969937); expected 358.6 (0.02)
Passed bias filter:                      661  (0.0368676); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 1.11u 0.35s 00:00:01.46 Elapsed: 00:00:00.54
# Mc/sec: 9373.91
//
Query:       EFC39676.1  [L=241]
Description: hypothetical protein NAEGRDRAFT_81258 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       563  (0.0314016); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 1402.74
//
Query:       EFC39677.1  [L=724]
Description: hypothetical protein NAEGRDRAFT_59247 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (724 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2544  (0.141893); expected 358.6 (0.02)
Passed bias filter:                      319  (0.0177924); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.81u 0.30s 00:00:01.11 Elapsed: 00:00:00.51
# Mc/sec: 4232.41
//
Query:       EFC39678.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.5e-06   27.5   0.0    6.2e-06   26.2   0.0    1.8  1  Fibrinogen_C  Fibrinogen beta and gamma chains, C-terminal gl
    0.00036   20.9   6.3    0.00036   20.9   6.3    3.0  2  EGF_2         EGF-like domain
  ------ inclusion threshold ------
       0.15   12.1   0.0       0.51   10.4   0.0    1.9  1  EFG_C         Elongation factor G C-terminus


Domain annotation for each model (and alignments):
>> Fibrinogen_C  Fibrinogen beta and gamma chains, C-terminal globular domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.0     1e-09   6.2e-06      14      47 ..     216     247 ..     201     292 .. 0.88

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 1e-09
                   -S-EEEEE-SSTTS--EEEEEE-SCCCS-EEEEE CS
  Fibrinogen_C  14 ktsglytitpdkakkafevyCdmetdggGWtvlq 47 
                   + sgly i+p ++   ++vyCdm+tdggGWt++ 
    EFC39678.1 216 EGSGLYQIKPGNT--VMTVYCDMDTDGGGWTMFA 247
                   5699****99876..99**************996 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   5.3      0.19   1.1e+03      14      32 .]     122     135 ..     112     135 .. 0.79
   2 !   20.9   6.3   5.9e-08   0.00036       6      32 .]     149     174 ..     144     174 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.19
       EGF_2  14 CvnqcGqCdCdsgyqGktC 32 
                 C+   G   C sg+ G +C
  EFC39678.1 122 CN--QG---CASGWAGINC 135
                 77..66...99******99 PP

  == domain 2  score: 20.9 bits;  conditional E-value: 5.9e-08
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +++ +C+C+s y G++C
  EFC39678.1 149 SVCSGRGNCTSSN-KCSCKSPYIGDNC 174
                 68*******9888.************* PP

>> EFG_C  Elongation factor G C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   8.5e-05      0.51      39      67 ..     267     295 ..     255     307 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 8.5e-05
                 .TTEEEEEEEEEGGG-TTHHHCHHHCTTT CS
       EFG_C  39 asgrviieaeiPlaeligfateLrslTkG 67 
                 ++++ +i+++iP+++l++ +t++r+ T  
  EFC39678.1 267 TTTNDTITFHIPTSDLMNISTQIRASTDS 295
                 58899********************9964 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       675  (0.0376485); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 3036.65
//
Query:       EFC39679.1  [L=592]
Description: hypothetical protein NAEGRDRAFT_59249 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (592 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1111  (0.0619666); expected 358.6 (0.02)
Passed bias filter:                      399  (0.0222544); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.71u 0.31s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 3331.69
//
Query:       EFC39680.1  [L=229]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (229 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       417  (0.0232584); expected 358.6 (0.02)
Passed bias filter:                      270  (0.0150594); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.55u 0.30s 00:00:00.85 Elapsed: 00:00:00.52
# Mc/sec: 1315.82
//
Query:       EFC39681.1  [L=512]
Description: RGS domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.9e-06   27.1   3.1    1.1e-05   25.6   3.1    1.8  1  RGS          Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.044   14.1   0.0       0.12   12.7   0.0    1.7  1  DDE_Tnp_1_5  Transposase DDE domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   3.1   1.3e-09   1.1e-05       5     117 ..     330     491 ..     327     492 .. 0.90

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 1.3e-09
                 HHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS............................................SHHHHHHHHHHHHHHHHTS CS
         RGS   5 lledqpgrslFreFlesefseenlsFwlaveefkka............................................keqeelkkkakeIyneyla 59 
                  +ed  +r +F+  +e+e+s+en  ++++++ +++                                             + + +  + a+eI+ e+l+
  EFC39681.1 330 TMEDDGLRAVFKIHCEKEKSSENYLLLEKIQYYRSLcerslelqaklfrddpnsdsssdisesahpakkkkesslereynELEVKKYEVAFEIFTEFLE 428
                 578889**********************************************************************8854444444455********** PP

                 TTSTTSSTS-HHHHHHHHHHHCSS......STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS  60 psspkelnidkklreelekrleke......qpsrklfeeaqeevfellekdsypkFlkselylr 117
                      ++ni++ l++ ++++l k       +  +++f+ +++e++ ++  d +++F +s  ++r
  EFC39681.1 429 VTGVMSVNISHLLVNAVKDKLDKYndkqidSLPEDMFNVLEKETCLVMM-DTHHRFKQSLAFQR 491
                 *********************9988999988899999999999998885.78899999999875 PP

>> DDE_Tnp_1_5  Transposase DDE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   1.4e-05      0.12      22      91 ..      80     148 ..      69     157 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 1.4e-05
  DDE_Tnp_1_5  22 kkngkrgrpqvysdaaiqtcltvkvlfklplRqlqGfvqsllklaglellvpdystlsrraktlevkipv 91 
                   ++gk g +   s ++++tc  v  l ++ l  l G+v  ++ l+ l   +   s ++  +k++++ i +
   EFC39681.1  80 SESGKSGSSFSHSKLMLRTCCGVVELTSMKLACLAGMVVTVFGLLVL-AAISIASFVMATNKSTDILINI 148
                  5679****************************************998.4455556666666666665544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (512 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1813  (0.101121); expected 358.6 (0.02)
Passed bias filter:                      588  (0.032796); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.72u 0.32s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 2998.76
//
Query:       EFC39682.1  [L=505]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.8e-18   65.6   1.3    1.3e-17   64.7   0.7    1.9  2  DUF563    Protein of unknown function (DUF563)


Domain annotation for each model (and alignments):
>> DUF563  Protein of unknown function (DUF563)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0      0.34     6e+03      61      75 ..      85      99 ..      30     127 .. 0.55
   2 !   64.7   0.7   7.2e-22   1.3e-17      72     208 ..     266     411 ..     148     412 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.34
      DUF563 61 epvhveklivpvppr 75
                 + +++kl++ +p  
  EFC39682.1 85 DRDFIRKLLMDHPIN 99
                223333444444444 PP

  == domain 2  score: 64.7 bits;  conditional E-value: 7.2e-22
      DUF563  72 vpprssggfqgallp...klrdrlrerlnlekr..kkp.trvlyisRlkagsRrilNeeevlkllp.krg....fevvdpeslsfeeqiklfssakviv 159
                   +r  ++++  ++    ++  +++++++ ++   k+p  ++l i R   ++R i+N +e+ k l+ ++g    +++ +  ++sf eqi++ + a+vi+
  EFC39682.1 266 FESRVVPRPPKEAILmtnQYFSFIKQSYGYSNEkrKNPkLNILLIRR--VKNRVITNLDEIYKTLKiNYGdvceIQIRENFKHSFDEQIAYHQWADVII 362
                 44444444444444366688889999998888876333579999***..99***************9999987777666669***************** PP

      DUF563 160 gphGsgltnliFmppgttvielvppnrldnsfenlaallglkyayvlge 208
                  +hG+  tn++  ++gt++ie+ +p++++++f   a+ll l+++ ++g+
  EFC39682.1 363 VSHGADETNTFLTREGTVIIEVESPQHYEPYFPVYAHLLKLRHYMFRGS 411
                 ********************************************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (505 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.25s 00:00:00.84 Elapsed: 00:00:00.44
# Mc/sec: 3432.19
//
Query:       EFC39683.1  [L=649]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.088   13.4   1.1        6.8    7.4   0.0    2.5  2  Ipi1_N    Rix1 complex component involved in 60S ribosome mat


Domain annotation for each model (and alignments):
>> Ipi1_N  Rix1 complex component involved in 60S ribosome maturation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0   0.2     0.004        73       9      65 ..     369     428 ..     362     449 .. 0.72
   2 ?    7.4   0.0   0.00038       6.8      42      89 ..     587     630 ..     574     641 .. 0.73

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.004
      Ipi1_N   9 slllyirsAmTHispdIredslkfLdllLevapeelvssawvktLnnflallg.wsk..e 65 
                 ++ll    ++  i+   r+ ++ +L+  ++ ++  + s a+v +  +f++++  ws+  +
  EFC39683.1 369 NILLICFISLVEITYFARNFTMPILNFAIDDVGGTIRSAAFVCMALCFCSMIVhWSHtlD 428
                 56666667777788888999999**********9966666***********962444441 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.00038
      Ipi1_N  42 eelvssawvktLnnflallgwskeksskgstsakatsssssskktskk 89 
                 e ++s+a  ++Ln+ +++l +++e+s++ +t+    sss +s+k +k+
  EFC39683.1 587 E-SCSEAVHRILNCEIGCLARKEEESTNTETNH--PSSSHNSRK-TKA 630
                 3.36666779***********887777777775..666667666.333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (649 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1321  (0.0736795); expected 358.6 (0.02)
Passed bias filter:                      508  (0.028334); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.37s 00:00:01.12 Elapsed: 00:00:00.53
# Mc/sec: 3678.26
//
Query:       EFC39684.1  [L=366]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (366 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       754  (0.0420548); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.25s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 2382.28
//
Query:       EFC39685.1  [L=1148]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-06   27.3   3.0    1.9e-06   27.3   3.0    4.2  2  G-alpha   G-protein alpha subunit


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?  -18.4  42.5         1   1.8e+04      24     240 ..       1     310 [.       1     687 [. 0.74
   2 !   27.3   3.0   1.1e-10   1.9e-06     217     347 ..     837    1004 ..     833    1009 .. 0.77

  Alignments for each domain:
  == domain 1  score: -18.4 bits;  conditional E-value: 1
                 EEEEEEESTTSSHHHHHHHHHHHCS--..--HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCC...CS-HCHHHH........ CS
     G-alpha  24 vkllllGqseSGKsTilkqlkllykkg..fseeelatwraviqlnivrsiktilealesleselsesfelqelkerldp...lkkveasliaklssate 117
                 +k+ll G +eSG sT+++q+kll +     s++  +t  +   +n+ ++ ++  ++ es +++++ + ++qe   +l +   +k+ +++ ++++ss++e
  EFC39685.1   1 MKILLYGMAESGLSTLFNQFKLLPNSVplLSQNTTQTNSNTSSNNTSNNNNSNSNNNES-NNNIDGNNHHQEQITSLTEdttIKQHDENNNNTFSSPEE 98 
                 69*******************99865565555544555555555555544444444444.333322223333333332201123333333333333333 PP

                 ....................................................HHCCHHC-HCHHH.................................. CS
     G-alpha 118 ee..................................................qeiefnpraevge.................................. 132
                 +e                                                              +                                  
  EFC39685.1  99 DEtpssssaitlspstdttkpavpsqalkpslkrptisplqftpppsnsrktI-----------Ttlanpssssttspqevfqsnhpthikflkrrkqa 186
                 33666665555555555555555555555555444444444444433333330...........03444444444444444445555544444444444 PP

                 .............HHHHHCCSHHHHHHHCCG.CCTT--TTHHHHHCT.HHHHCST..T----CHHHHCS-----SEEEEEEEC.T-TEEEEEEEE-SSH CS
     G-alpha 133 .............dikaLwndpgiqelyerr.nkiklednaeyFldd.leritsp..dYlptddDilkarlktvGisetkfev.dsklefrivdvgGqr 213
                                + L + + + +  err   +++++ ++ Fl + + r +    +Y+++++  l      ++ s  ++++ ++++++++++v  + 
  EFC39685.1 187 fnehflknlpnafLTQLLISFKLLIHHAERRdLLFSMDERLQEFLMErIVRDARLesNYVKNSSSTLLIV-APSSSSSNNINInNNNNNLNLLNVVTSS 284
                 4455444544443222222333333333333255556677777766444443333357888777766663.3333444444443347778888888888 PP

                 HHHHGTCCCTTTECEEEEEEEGGGTT- CS
     G-alpha 214 serkkWvpffddvdaiiFlvslsefdq 240
                 s  ++  + ++dv+++i + + s ++ 
  EFC39685.1 285 SSSQQLSSSYSDVETLI-VPPSSSINN 310
                 88888888888888776.334444444 PP

  == domain 2  score: 27.3 bits;  conditional E-value: 1.1e-10
                  HGTCCCTTTECEEEEEEEGGGTT-.....B-SS-T..TSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGG.CCTT--...... CS
     G-alpha  217 kkWvpffddvdaiiFlvslsefdq.....vlyede..kvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgklsk.yfpsye...... 299 
                  + W+ +    ++++F v+l ++ +     v y d+  ++ ++  sl+ F++  n k++ + pi+L ++ +D++e+    ++l++   +++e      
  EFC39685.1  837 NEWIMCCYASNMVVFAVNLCDYLKsilvkVEYSDKlmEKKKISYSLEKFEQCANGKYFSELPIVLCFTFVDVFEQGQHYNPLTEqQKSDIEqivqql 933 
                  67********************8876665445554445999***********************************998888772333333666666 PP

                  ......................H.CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEE.EE-TT-HHHHHHHH CS
     G-alpha  300 ......................grkndlesvlkylrnkFeeihkeksnnrrkiyth.ftsatdtkevqkvi 347 
                                        ++ +  ++ +++++++++++ +++++++++  ++ + +++d++ +++v+
  EFC39685.1  934 npasygqkktenaplnvhtkldQKRKPWHDSCEFIIQQYIHLATAEQRRKQVRESFvVLNCIDSRRTAQVL 1004
                  67777788888888888887767777789999**********88775444333333244589999999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1148 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2274  (0.126834); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.13u 0.36s 00:00:01.48 Elapsed: 00:00:00.52
# Mc/sec: 6608.55
//
Query:       EFC39686.1  [L=508]
Description: hypothetical protein NAEGRDRAFT_59188 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      9e-63  212.3   0.2    1.2e-62  211.9   0.2    1.1  1  Metallopep    Putative peptidase family
     0.0018   18.5   0.9     0.0058   16.8   0.0    2.4  3  Reprolysin_5  Metallo-peptidase family M12
  ------ inclusion threshold ------
      0.026   15.1   0.0      0.091   13.3   0.0    2.0  1  Reprolysin_3  Metallo-peptidase family M12B Reprolysin-like


Domain annotation for each model (and alignments):
>> Metallopep  Putative peptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  211.9   0.2     2e-66   1.2e-62       2     389 ..       4     373 ..       3     410 .. 0.81

  Alignments for each domain:
  == domain 1  score: 211.9 bits;  conditional E-value: 2e-66
  Metallopep   2 ievenlqdneevsqpvvlvkGkisekk....sekkkgkvkvehndksfppltwpvndseFKalvhLspgenrltve...........kesevasseltl 85 
                 i + n+qdn++  ++++ + G i+ ++    s+ ++++  + +++ +  +++w+v +s FKal+ Ls+g n+l+++            + + + s ++ 
  EFC39686.1   4 ISLSNHQDNSTYGYSLLRLCGAIKGHSktntSNGAQNQWLLITQQPANKTTRWEVRESSFKALILLSEGVNTLQLKlesnpneilgnFTFTYDASLINN 102
                 567899*****99999988888776552111333445555556776688888************************99999999776666667777777 PP

  Metallopep  86 nykpleqnppvhlvilvakdsdgtfdapeaklekeegndldaaikklrlaarLlQaftaeklrrkglgrrtFrleeevetdtlvqesetlrsevkvhvl 184
                   +  +  ++v +v  v+ d+dg+f++ e        ++ + a +kl +aa + Q+f ae l++    ++tF le e   d          +  +v ++
  EFC39686.1 103 WNRENKMIKRVIPVHFVCSDHDGSFQSIE------GCQTAEIARQKLGVAALMYQTFCAEALKH----NKTFGLEMES--DR--------TNMPHVMTF 181
                 777777788999***************77......566899*********************98....58******99..22........345789*** PP

  Metallopep 185 rsektvaelrdldlAQQnskakdedeLfqiaaealkksgepesdkkvkvavllldthydkkrklitgHaALGGggseikLaiFGshglyswPssleevv 283
                 +s+k +     +  A   +      + ++ + e+l++++   ++ +  + ++l+ ++y++++++++  +ALGGg+    La+     lys++++++e+v
  EFC39686.1 182 KSKKWTRS---ALEALGDHWNDGGCAGWSAIYEELEEHD--MHNPNFIYFCVLAGSKYNTTTHKTQMGTALGGGK----LALWTDCTLYSYAKNVDEIV 271
                 **999888...3333333333444467***********8..577789999999**********************....******************** PP

  Metallopep 284 pafldatrvdtaevanDsnergtywealaitlGAflHEiGHllglpHqedGvmlrdydalnrsfttreaeskrtkskgkrkvlpkeectwsrldalrfr 382
                 +++ld+++vd++++ +Ds +rg+yw++++++lGA++HE+GH++g+pH++ G+m+r++d++nr f++ e+  +  +++   k + + ++ w+  ++  ++
  EFC39686.1 272 KCLLDNRKVDVNKLPDDSCYRGSYWANYSTGLGAAMHELGHCFGCPHTPGGIMARGFDDFNRFFMISEPGDN--QAII-TK-THELGAFWEDSSIAIIL 366
                 *******************************************************************99543..2222.11.23445555555555555 PP

  Metallopep 383 yhpsfal 389
                  hp+   
  EFC39686.1 367 KHPVVGS 373
                 5555555 PP

>> Reprolysin_5  Metallo-peptidase family M12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.9   0.0       2.1   1.2e+04      10      29 ..      94     113 ..      92     116 .. 0.73
   2 !   16.8   0.0   9.7e-07    0.0058     137     161 ..     297     321 ..     235     329 .. 0.85
   3 ?   -3.1   0.1       1.2   7.4e+03     122     149 ..     395     424 ..     385     425 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.9 bits;  conditional E-value: 2.1
  Reprolysin_5  10 aaDcsfvaafggdaaaqani 29 
                    +D+s+ ++++ ++++ +++
    EFC39686.1  94 TYDASLINNWNRENKMIKRV 113
                   58999999997754666655 PP

  == domain 2  score: 16.8 bits;  conditional E-value: 9.7e-07
  Reprolysin_5 137 vstatevqvvaHElGHnfGavHDcd 161
                    + +t + + +HElGH fG++H++ 
    EFC39686.1 297 ANYSTGLGAAMHELGHCFGCPHTPG 321
                   4577889999************985 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 1.2
  Reprolysin_5 122 agsvstrveks..nsvvvstatevqvvaHE 149
                   ++sv+t+ ++   ++v  ++ + + ++ HE
    EFC39686.1 395 VSSVNTNSMMDchYYVCGKSFENDSSFEHE 424
                   445555544448788888888889999998 PP

>> Reprolysin_3  Metallo-peptidase family M12B Reprolysin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   0.0   1.5e-05     0.091     106     124 .]     301     319 ..     272     319 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 1.5e-05
  Reprolysin_3 106 vgadtvaHEiGHnfganHt 124
                   +g  +++HE+GH fg +Ht
    EFC39686.1 301 TGLGAAMHELGHCFGCPHT 319
                   455899************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       537  (0.0299515); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.25s 00:00:00.77 Elapsed: 00:00:00.41
# Mc/sec: 3728.69
//
Query:       EFC39687.1  [L=397]
Description: hypothetical protein NAEGRDRAFT_82752 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.9e-18   66.0   0.0    9.1e-18   64.8   0.0    1.6  1  AAT       Acyl-coenzyme A:6-aminopenicillanic acid acyl-trans


Domain annotation for each model (and alignments):
>> AAT  Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.8   0.0   5.1e-22   9.1e-18       6     225 ..     139     383 ..     135     384 .. 0.83

  Alignments for each domain:
  == domain 1  score: 64.8 bits;  conditional E-value: 5.1e-22
                 ..EEEEEEEE-S-S--EEEEE--S.......SS--EEEE..SSSS-SEEEEEETTS-EEEE-T...TS-TTT---------HHHHHHH.--SHHHHHHT CS
         AAT   6 gkllgrNeDldpetlsnrflvvased.....sgfaslgy..agslpGrtdGiNeaGLavtinl...lslkklrakGfprafitRllLekcesveeAvel 94 
                 +++lg+NeD+dp t +  +lv+ ++      + f ++ y  ag+lpG+ ++ +++ La ++n    l l k  ++G++r+f+ R + e ++++ ++ e 
  EFC39687.1 139 TAILGHNEDADPYTQDYDYLVKSCIKtndqaEPFVFVAYhyAGQLPGNAFAWTKY-LALSTNAqfpLVLPKA-GYGLGRNFVNRKVYE-SKTIAQVTET 234
                 469*********************88999**5555555544***********999.9999965333555666.9**************.********** PP

                 HHHH....TTTS-SEEEEEEETTEEEEEEE-SSS-EE................EEEESS..EEEEE-SS-S-GGGSSS-----HHHHHHHHHHHHHHCS CS
         AAT  95 lkei....praaginyivldaagnaavveveasskvc................sirean..ealahtNHfvnetleaenqnilesSisRlerlqellsq 171
                 l +     + + + n+  l + +  a++e+ + +                   ++ + +  +++ h+N + n ++ +      +sS +R +r+ + ++ 
  EFC39687.1 235 LSKFsgmlASGFASNVAPLYDTQSSALYEMRSFENAPrvnnsiamsmhsilpfNVLSSSgqSFYFHVNMYRNLSVPEF---LDPSSVHRTARFNQFTKI 330
                 ***98866555555666566666777676654333333679999999999999777777889********88888776...899*********998876 PP

                 SSSBHHHHHHHT---STTTSSSS-...BSSSEEEEEEE-TTS--EEEEEE--TT CS
         AAT 172 kesaeeaiellkDredepysvlrrksfkswenTiltalydlaarkaklvlgnpk 225
                  +++ ++++ll D++d++++++r+  ++++ +T++t+l+ l  rk++++ +npk
  EFC39687.1 331 ETEE-QVLALLGDTYDKEFPIYRQPTKTDDASTVATVLFNLITRKVTVYNKNPK 383
                 6666.********************************************99997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       468  (0.026103); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.60u 0.30s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2460.43
//
Query:       EFC39688.1  [L=331]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-06   29.0   1.5     0.0005   20.4   0.1    3.0  3  Helicase_C  Helicase conserved C-terminal domain
    0.00083   19.2   0.1     0.0023   17.7   0.1    1.8  1  DEAD        DEAD/DEAH box helicase
  ------ inclusion threshold ------
       0.13   11.6   0.0       0.34   10.2   0.0    1.6  1  CMS1        U3-containing 90S pre-ribosomal complex subunit


Domain annotation for each model (and alignments):
>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0018        11      10      59 ..      28      84 ..      20     106 .. 0.82
   2 ?   -1.8   0.0      0.63   3.8e+03      12      54 ..     126     166 ..     117     171 .. 0.68
   3 !   20.4   0.1   8.4e-08    0.0005       2     101 ..     186     282 ..     185     286 .. 0.84

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0018
                H....HHTTTTSEEEEEESSHHHHHHHHHHHHHT...TSTEEEESTTSTHHHHHHHH CS
  Helicase_C 10 l....kleeeggkilifvntidrlekvklllekk...gikvavlhgelpqnereeil 59
                +    k+e +++k++++ n +  ++ v +ll+++   +ikv+ l  + + n+ + il
  EFC39688.1 28 VermkKEETRKKKTIVIGNGKMWFYTVGYLLKTFggdEIKVCNLVEDQTYNQENIIL 84
                2333589999************88888***99999888****999999888877665 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.63
                 HTTTTSEEEEEESSHHHHHHHHHHHHHTTSTEEEESTTSTHHH CS
  Helicase_C  12 leeeggkilifvntidrlekvklllekkgikvavlhgelpqne 54 
                 l++++ +i  f+ +++++ +  +l  k+ i + +l+ e ++n+
  EFC39688.1 126 LRNVNCQIFWFSSKRNDFTNEIYL--KSPIVIEPLQDEKSTNQ 166
                 478888899999999877534444..66677777777776666 PP

  == domain 3  score: 20.4 bits;  conditional E-value: 8.4e-08
                 HHHHHHHHHHHTTTTSEEEEEESSHHHHHHHHHHHHHTTSTEEEESTTSTHHHHHHHHHHHHTTSSSEEEESGGGTSSSTSTTESEEEESSSSSSHHHH CS
  Helicase_C   2 kleallellkleeeggkilifvntidrlekvklllekkgikvavlhgelpqnereeileqfnkgesdvLiatdvaerGidipkvnlVinfdlprnvtsy 100
                 k+e+l +ll    +  ++ i++nt +r+ +++  le+++ ++ +lh e++ +e e+ +++f++  ++ Li ++     +++ + +  +n+dlp++ ++y
  EFC39688.1 186 KPETLPDLL--DYISAQCAIYCNTYERAIEISRALEREHHTAHCLHNEMSDSEIEQKINDFRNAIVQNLIISNYKFPKLNF-NPKITVNYDLPWQNDKY 281
                 667777776..678999*********7755555579999***********************9999999999988888999.68888999999988888 PP

                 H CS
  Helicase_C 101 i 101
                 +
  EFC39688.1 282 V 282
                 6 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.1   3.9e-07    0.0023      94     145 ..      77     125 ..      21     138 .. 0.72

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 3.9e-07
                 HHTTCSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  94 ldngvdivvgtpgrlddllstgklnlsqvrflVlDEadrlldqgfsdfinri 145
                   n+ +i++gtp+++ +ll++g++n+ ++++lV+D  d+l+   f   +++i
  EFC39688.1  77 Y-NQENIILGTPDKINELLESGNVNCTDINLLVVDQPDELSR--FDLSMHAI 125
                 2.6689*********************************987..44444444 PP

>> CMS1  U3-containing 90S pre-ribosomal complex subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.2   0.0   5.6e-05      0.34     163     209 ..      65     111 ..      56     119 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 5.6e-05
        CMS1 163 hikleesvtylkksrigiavGtpgRildLleeeslsvdeLkrivlDa 209
                  ik+ + v     ++  i +Gtp++i +Lle + +++ +++ +v+D 
  EFC39688.1  65 EIKVCNLVEDQTYNQENIILGTPDKINELLESGNVNCTDINLLVVDQ 111
                 5777777777777888899**************************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (331 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       926  (0.0516482); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.58u 0.26s 00:00:00.84 Elapsed: 00:00:00.45
# Mc/sec: 2227.39
//
Query:       EFC39689.1  [L=342]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-05   24.8   0.0    2.6e-05   24.1   0.0    1.5  1  DEAD        DEAD/DEAH box helicase
     0.0016   18.8   0.9      0.014   15.7   0.1    2.6  2  Helicase_C  Helicase conserved C-terminal domain
  ------ inclusion threshold ------
       0.03   13.7   0.1       0.14   11.4   0.0    1.9  2  CMS1        U3-containing 90S pre-ribosomal complex subunit


Domain annotation for each model (and alignments):
>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.1   0.0   4.3e-09   2.6e-05      93     149 ..      95     149 ..      40     163 .. 0.79

  Alignments for each domain:
  == domain 1  score: 24.1 bits;  conditional E-value: 4.3e-09
                 HHHTTCSEEEEEHHHHHHHHHCTSSHCTTEEEEEEETHHHHHHTTTHHHHHHHHHHS CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD  93 kldngvdivvgtpgrlddllstgklnlsqvrflVlDEadrlldqgfsdfinrilnql 149
                 k + ++d+++gtp+++ dll++g +n++++++lV+D  d+  +  f   +++il+++
  EFC39689.1  95 KYQGNYDVLIGTPEKIKDLLESGIVNCKDISLLVVDQLDEWNE--FNLNMHEILRNV 149
                 233459*******************************999877..555666665555 PP

>> Helicase_C  Helicase conserved C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   0.1      0.08   4.8e+02      40      66 ..      57      83 ..      19     192 .. 0.67
   2 !   15.7   0.1   2.4e-06     0.014       2     100 ..     205     301 ..     204     303 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.08
                TSTEEEESTTSTHHHHHHHHHHHHTTS CS
  Helicase_C 40 gikvavlhgelpqnereeileqfnkge 66
                +i++++  g +     ++ l+ f  +e
  EFC39689.1 57 NITIVIGKGYMWFHTVRHLLKTFGGDE 83
                555555566565555665555553222 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 2.4e-06
                 HHHHHHHHHHHTTTTSEEEEEESSHHHHHH.HHHHHHHTTSTEEEESTTSTHHHHHHHHHHHHTTSSS.EEEESGGGTSSSTSTTESEEEESSSSSSHH CS
  Helicase_C   2 kleallellkleeeggkilifvntidrlek.vklllekkgikvavlhgelpqnereeileqfnkgesd.vLiatdvaerGidipkvnlVinfdlprnvt 98 
                 kle l +ll  e +  +++i++n+ + ++   ++l + +++ v +l  +++  e e+  ++f++g+++  Li  +     + + + ++Vinf+lp++ +
  EFC39689.1 205 KLEVLEALL--ETIPINTVIYCNSDNVANGiSNYL-QAHNLAVSCLSKDMSELEIEQKTNEFREGNVQlHLILANLKVSRLKF-NPRVVINFNLPWQND 299
                 667777776..89999**********886656777.5668****************************888888887777888.79*********9988 PP

                 HH CS
  Helicase_C  99 sy 100
                 +y
  EFC39689.1 300 KY 301
                 77 PP

>> CMS1  U3-containing 90S pre-ribosomal complex subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   2.4e-05      0.14     179     209 ..     101     131 ..      84     150 .. 0.81
   2 ?   -0.7   0.0      0.12   7.3e+02      66      81 ..     244     259 ..     218     262 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 2.4e-05
        CMS1 179 giavGtpgRildLleeeslsvdeLkrivlDa 209
                  + +Gtp++i dLle + ++++++  +v+D 
  EFC39689.1 101 DVLIGTPEKIKDLLESGIVNCKDISLLVVDQ 131
                 5779*************************96 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.12
        CMS1  66 lkriekDlsdveLeDk 81 
                 +  + kD+s++e+e k
  EFC39689.1 244 VSCLSKDMSELEIEQK 259
                 456789******9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (342 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       570  (0.0317921); expected 358.6 (0.02)
Passed bias filter:                      324  (0.0180713); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.59u 0.33s 00:00:00.92 Elapsed: 00:00:00.53
# Mc/sec: 1955.08
//
Query:       EFC39690.1  [L=160]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (160 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       597  (0.033298); expected 358.6 (0.02)
Passed bias filter:                      381  (0.0212505); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.30s 00:00:00.82 Elapsed: 00:00:00.50
# Mc/sec: 967.19
//
Query:       EFC39691.1  [L=551]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.49    8.9  20.7       0.63    8.5  20.7    1.1  1  Macoilin  Macoilin family


Domain annotation for each model (and alignments):
>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5  20.7   3.5e-05      0.63     253     377 ..      14     145 ..       2     235 .. 0.54

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 3.5e-05
    Macoilin 253 leyrekkksakssrsdskkkhehnesvdsklqekeymenkskskrlsksessgsesel..lveesvkskssssssssn..........knskkasagsa 339
                  ++r+++++++++r++s+++h+h+   ++++++ +   n+  +   +++++++  ++   +++ ++  ++ss++s  +          +n+++++++  
  EFC39691.1  14 QQQRNSDSDHQHHRQHSRNHHHHH---HHHHHQRNNNYNHRGNYDEYQNNNPTMRENSnhHHQYNIPYSHSSATS--QqggryfeqlnNNNNRHQQQYR 107
                 334444444444444444433333...222222333333333333333333333333300333333333333333..2358899998644444444455 PP

    Macoilin 340 gssnssskkhsessksvtsssssknskkqklpaGkssa 377
                 g  +sss++ + s  s +sss+s+  +k++ p  +s++
  EFC39691.1 108 GGNQSSSNQVRFSIPSSSSSSNSSRIEKNREPESHSAK 145
                 55566666666555555555555555666665444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (551 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1585  (0.0884043); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        56  (0.00312343); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.76u 0.31s 00:00:01.07 Elapsed: 00:00:00.55
# Mc/sec: 3017.36
//
Query:       EFC39692.1  [L=614]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.4e-15   57.6   1.5    7.8e-14   52.0   0.9    3.4  2  RGS          Regulator of G protein signaling domain
      2e-06   27.4   0.0    3.3e-06   26.7   0.0    1.3  1  START        START domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.0   0.9   8.7e-18   7.8e-14      11     115 ..      39     230 ..      29     233 .. 0.96
   2 ?    1.0   0.0     0.054   4.9e+02      93     115 ..     435     457 ..     410     459 .. 0.88

  Alignments for each domain:
  == domain 1  score: 52.0 bits;  conditional E-value: 8.7e-18
                 HHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..................................................................... CS
         RGS  11 grslFreFlesefseenlsFwlaveefkka..................................................................... 40 
                  ++ F +Fl++e +   l+F+ +++e+ ++                                                                     
  EFC39692.1  39 IMNGFLDFLKNELNASSLEFLVKIDEYSNShnsstfysngssvnnvnspagllpsiqtstttistisigsplspsvsstsftspgrkvqrkdslkdlte 137
                 56779********************************************************************************************** PP

                 ..........SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS........STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHH CS
         RGS  41 ..........keqeelkkkakeIyneylapsspkelnidkklreelekrleke........qpsrklfeeaqeevfellekdsypkFlksely 115
                           +++ ++k+kakeI++++l+++s++++n+++++r+ + ++ eke          +++lf+ea +ev   l+ ds+ +Flks  +
  EFC39692.1 138 hnsifsqpfnNNKISRKAKAKEIIDKFLNDHSAHQVNLSSQIRDAVLRNYEKEcsrgggenDINPHLFDEARTEVSLQLKCDSFVRFLKSHSF 230
                 ********9999999999******************************************999***************************988 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.054
                 HHHHHHHHHHHHHHHHHHTSHHH CS
         RGS  93 aqeevfellekdsypkFlksely 115
                 + + + +++++  +++F+k + y
  EFC39692.1 435 ILNIIDDTMSNVKFERFVKGPTY 457
                 55667899***********9999 PP

>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.0   3.6e-10   3.3e-06      93     199 ..     460     565 ..     431     573 .. 0.87

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 3.6e-10
                 EEEEEEE--TT..-SS-EEEEEEEEEEE....TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEEXEEXXSSXXHHHHHHHH CS
       START  93 alqlyvaelvalsplspRdfvflRsire...lgdgsyvivdrSvtseqnppesssvvRaellpSgilieplgnghskvtwvehvdlkgwlpkwllrslv 188
                 ++   ++++++  p+s R f++  sir    ++  +y+i+ rS + +  p  s+++++ + ++ g +ie+l++ h+++t    vd++g+ p +l++  +
  EFC39692.1 460 SYLSSKMKMAW--PMSDRQFLIGTSIRDetfDSYNGYTILRRSHDCKEVPL-SKGCIK-GIFLGGVVIEKLSEKHTRFTASGFVDMGGKFPLSLFNKIL 554
                 45556778888..***************99999********9988776666.9*****.89************************************** PP

                 HHHHHHHHHHH CS
       START 189 ksglaegaktw 199
                 + ++++g+   
  EFC39692.1 555 SLRQSKGVENV 565
                 *9999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (614 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       836  (0.0466284); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.61u 0.33s 00:00:00.94 Elapsed: 00:00:00.47
# Mc/sec: 3921.55
//
Query:       EFC39693.1  [L=612]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-11   44.0   0.6    4.6e-05   23.9   0.0    4.7  5  Ank_2     Ankyrin repeats (3 copies)
      2e-06   28.2   0.0     0.0099   16.4   0.0    3.7  4  Ank_4     Ankyrin repeats (many copies)
     0.0018   18.6   0.0          6    7.8   0.0    4.5  5  Ank_3     Ankyrin repeat


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.3   7.8e+03      66      81 ..      73      87 ..      60      91 .. 0.53
   2 ?    0.6   0.1      0.15   8.9e+02      24      49 ..     193     220 ..     168     238 .. 0.70
   3 !   23.9   0.0   7.8e-09   4.6e-05      13      73 ..     243     311 ..     232     321 .. 0.78
   4 !   11.8   0.0   4.6e-05      0.27      25      60 ..     327     369 ..     310     376 .. 0.75
   5 ?    1.6   0.0     0.072   4.3e+02      51      73 ..     411     437 ..     383     471 .. 0.52

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.3
       Ank_2 66 leivklLlekgadinl 81
                +e+++ Ll + a+i++
  EFC39693.1 73 QECLEELL-SLAHITQ 87
                47777777.4456655 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.15
       Ank_2  24 kngktaLhyAakngnleivklLleh..a 49 
                 +++++++h++ak+ + +i++  ++    
  EFC39693.1 193 EFDMNVVHLSAKHAQADILQHVISSacC 220
                 2668999999999999999988874442 PP

  == domain 3  score: 23.9 bits;  conditional E-value: 7.8e-09
       Ank_2  13 vklLlegadpnkngktaLhyAakngnleivklLleh..........adndgrtpLhyAarsghleivklLl 73 
                  + Ll+++d   ++ t+++yA+++g++ i+ +L+++          ad++g  p h+A + +++ei + L 
  EFC39693.1 243 TNALLSSVDK--QNATPIFYAVQSGSNGICAFLCSFkivqdqlnlhADRYGFLPVHWALKRKQFEISDTLQ 311
                 4667755553..679*******************95566566666677***********999999988875 PP

  == domain 4  score: 11.8 bits;  conditional E-value: 4.6e-05
       Ank_2  25 ngktaLhyAakngnleivklLleh.......adndgrtpLhyA 60 
                  g+++Lh+A+++ + e +++L +         +++ +++L+++
  EFC39693.1 327 LGESVLHIAVREKSMESIEYLAKTkpgillkKNSQEENALFVC 369
                 7899********99999*****966777765668888999887 PP

  == domain 5  score: 1.6 bits;  conditional E-value: 0.072
       Ank_2  51 ndgrtpLhyAarsg....hleivklLl 73 
                  +gr++L+ ++ ++     + i+++L 
  EFC39693.1 411 GHGRNILMESIAKNdmssFYAILQYLY 437
                 334455555554422222234444443 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.0         3   1.8e+04      35      52 ..     195     212 ..     192     212 .. 0.74
   2 !   16.4   0.0   1.7e-06    0.0099       3      50 ..     256     306 ..     254     310 .. 0.84
   3 !    6.9   0.0    0.0016       9.7       3      43 ..     330     370 ..     328     382 .. 0.83
   4 ?   -1.0   0.0      0.48   2.9e+03      26      44 ..     442     468 ..     421     469 .. 0.65

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 3
       Ank_4  35 GetalhiAakrgnveilk 52 
                 +++ +h  ak+ + +il+
  EFC39693.1 195 DMNVVHLSAKHAQADILQ 212
                 567789999888877775 PP

  == domain 2  score: 16.4 bits;  conditional E-value: 1.7e-06
       Ank_4   3 taLhyaaisgrlelvrlLlekgad...inaqdnrsGetalhiAakrgnvei 50 
                 t+++ya++sg   ++++L ++++    +n  ++r+G+ ++h A+kr ++ei
  EFC39693.1 256 TPIFYAVQSGSNGICAFLCSFKIVqdqLNLHADRYGFLPVHWALKRKQFEI 306
                 89****************988854345444489**************9997 PP

  == domain 3  score: 6.9 bits;  conditional E-value: 0.0016
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhiAa 43 
                 ++Lh a+ +  +e++++L  +++ i   +n++ e+al  ++
  EFC39693.1 330 SVLHIAVREKSMESIEYLAKTKPGILLKKNSQEENALFVCL 370
                 799***************99999999999999999998877 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.48
       Ank_4  26 d.........inaqdnrsGetalhiAak 44 
                 +          n++ ++++ +++h +++
  EFC39693.1 442 StkqrlipilFNEV-DSQQKNLMHLCVQ 468
                 13334555568888.9999999999986 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       2.3   1.4e+04       6      23 ..      60      77 ..      60      79 .. 0.87
   2 ?    4.2   0.0     0.015        89       3      23 ..     255     275 ..     253     279 .. 0.86
   3 ?   -0.9   0.0       0.7   4.2e+03       1      17 [.     290     306 ..     290     318 .. 0.78
   4 !    7.8   0.0     0.001         6       2      23 ..     328     349 ..     327     356 .. 0.86
   5 ?   -0.9   0.0      0.66   3.9e+03       1      20 [.     412     435 ..     412     440 .. 0.70

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.3
       Ank_3  6 LhlAarsgnleivkfLle 23
                L++A+  g +++v+ +le
  EFC39693.1 60 LYQAVIKGMISRVQECLE 77
                678999999999999998 PP

  == domain 2  score: 4.2 bits;  conditional E-value: 0.015
       Ank_3   3 etpLhlAarsgnleivkfLle 23 
                  tp+++A+ sg+  i+ fL+ 
  EFC39693.1 255 ATPIFYAVQSGSNGICAFLCS 275
                 79***********99999976 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.7
       Ank_3   1 nGetpLhlAarsgnlei 17 
                 +G  p h+A++   +ei
  EFC39693.1 290 YGFLPVHWALKRKQFEI 306
                 577899***99999885 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.001
       Ank_3   2 GetpLhlAarsgnleivkfLle 23 
                 Ge+ Lh+A+r  + e +++L +
  EFC39693.1 328 GESVLHIAVREKSMESIEYLAK 349
                 99************99999987 PP

  == domain 5  score: -0.9 bits;  conditional E-value: 0.66
       Ank_3   1 nGetpLhlAarsgnl....eivkf 20 
                 +G+++L++ +  ++     +i+++
  EFC39693.1 412 HGRNILMESIAKNDMssfyAILQY 435
                 69999**99999887332224555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (612 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       880  (0.0490825); expected 358.6 (0.02)
Passed bias filter:                      425  (0.0237046); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.78u 0.36s 00:00:01.14 Elapsed: 00:00:00.57
# Mc/sec: 3209.28
//
Query:       EFC39694.1  [L=438]
Description: hypothetical protein NAEGRDRAFT_81187 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (438 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       393  (0.0219198); expected 358.6 (0.02)
Passed bias filter:                      257  (0.0143343); expected 358.6 (0.02)
Passed Vit filter:                        14  (0.000780858); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 2425.37
//
Query:       EFC39695.1  [L=960]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00021   21.3   0.0    0.00042   20.3   0.0    1.4  1  CHASE     CHASE domain
  ------ inclusion threshold ------
      0.015   15.3   0.0      0.037   14.0   0.0    1.6  1  PAS_8     PAS domain


Domain annotation for each model (and alignments):
>> CHASE  CHASE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   0.0   4.6e-08   0.00042      26     179 ..     419     555 ..     406     561 .. 0.80

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 4.6e-08
       CHASE  26 lgwaprvpaaeraafeaevraegfpdftirpage.rdeyfpivyiePlagnnaalGlDllseperrealerardtgrpvlsgpvrLvqededgqagfll 123
                 ++w  +v+++  ++f  +  +  ++ f i    +  + y+  + ++P++  ++ +G+ ++ ep+ re l+ a++t+ +++ gp+  ++    +q++++ 
  EFC39695.1 419 ISWDYNVDPDKFDEFAMKTSQ--YQYFNIIHTFGmTRNYT-LTEVYPMNVLKSLVGQEIGIEPNHREQLQIAIETNSTTIYGPFLTIN----NQYSLMA 510
                 566667777777777777533..33444444333134555.9*******************************************887....9****** PP

       CHASE 124 ylPvyrkegpetveerraallGfvyavfriddlleklllqlgaaeagldlaiyDgt 179
                  +P+ +          + +++Gf  +v++++++++++ l  ++  ++ +++ yD++
  EFC39695.1 511 QQPILDF---------NLNFWGFSLVVLEFGEIFQQVNL--TSLLENYSIRFYDNK 555
                 *****99.........336****************6665..467889999999943 PP

>> PAS_8  PAS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   4.2e-06     0.037      17      53 ..     699     737 ..     684     744 .. 0.76

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 4.2e-06
       PAS_8  17 vdlgd..rivdvNqaalellGys..adlkgellgqllpvlr 53 
                 +d  +  +i  vN+ +l l+Gy+   +l   +l+q+lp ++
  EFC39695.1 699 ID--EsaLINTVNRPFLTLFGYNdeSELENVDLQQILPLFD 737
                 55..3346999************888877777788888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (960 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1865  (0.104021); expected 358.6 (0.02)
Passed bias filter:                      459  (0.025601); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.91u 0.34s 00:00:01.25 Elapsed: 00:00:00.56
# Mc/sec: 5155.81
//
Query:       EFC39696.1  [L=354]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.8e-55  187.7  10.2    3.5e-55  187.5  10.2    1.1  1  Peptidase_C1    Papain family cysteine protease
      1e-05   24.5   2.7      0.012   14.4   0.0    2.1  2  Peptidase_C1_2  Peptidase C1-like family
     0.0026   17.6   0.0     0.0055   16.6   0.0    1.6  1  Propeptide_C1   Peptidase family C1 propeptide


Domain annotation for each model (and alignments):
>> Peptidase_C1  Papain family cysteine protease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  187.5  10.2   5.9e-59   3.5e-55       1     216 [.     132     349 ..     132     351 .. 0.89

  Alignments for each domain:
  == domain 1  score: 187.5 bits;  conditional E-value: 5.9e-59
                   STSCEETTTTTTG.SG---B-TSSBTHHHHHHHHHHHHHHHHHHS.SS---B-HHHHHHHSTTTSTGGGBB-HHHHHHHHHHTEBEBTTTS--SSSC CS
  Peptidase_C1   1 lpesvDwrekgga.vtpvkdqgsCGsCWafsavgaledrlaiktk.kklvslSeqelvdCskeenegCnGGlmenafeyikkggivtekdypYkake 95 
                   lp ++D+r++    + +v+dq++CG+CWafsa+ +l  rl+i+t+ k++v lS +  v+C++ +n+ C+GG+ ++a+++++++g + +++ pY + +
    EFC39696.1 132 LPMNFDARTQWRGcIPAVRDQQTCGACWAFSATYVLAHRLCIATNgKTNVVLSPEYQVQCDT-MNKACQGGYLKYAWSFLERTGTTVDSCIPYASGR 227
                   6999*****55334*******************************99**************9.9******************************666 PP

                   S........SS-CGCGGGSEEBEESEEEEEESSBHHHHHHHHHHHSSEEEEEECCSHHHHTEESSEESSTSCETSS-EEEEEEEEEEEETTEEEEEE CS
  Peptidase_C1  96 g........gkCkkkkkkekvakikgygkvkenseealkkalakngPvsvaidaseedfqlYksGvyketecsktelnhavlivGygvengkkyWiv 184
                             kCk ++++++++k k+ + ++    +++k+a++++g v+  +++++ df++Y+sGvyk+ + + t   hav+++G+gve+g++yW++
    EFC39696.1 228 AtfssgtcpAKCKVSTQSMTMYKAKNSRYISG--VNNIKAAIMSYGSVQSGFTIYR-DFMSYRSGVYKHVSTT-TLGGHAVALIGWGVESGTNYWLA 320
                   66888666666666666555666666666665..799*******************.6***********8666.488******************** PP

                   E-SBTTTSTBTTEEEEESSSSTGGGTTSSEEE CS
  Peptidase_C1 185 kNsWgtdwgekGYiriargknnecgieseava 216
                    NsWg++wg++GY++ia+g   ecgie++++a
    EFC39696.1 321 VNSWGSNWGMSGYFKIAQG---ECGIENQVYA 349
                   *****************98...8*****9986 PP

>> Peptidase_C1_2  Peptidase C1-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0     2e-06     0.012      57     105 ..     148     197 ..     131     203 .. 0.86
   2 !    9.7   1.0   5.5e-05      0.33     358     398 ..     299     337 ..     288     341 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 2e-06
                     S--B--BSSTHHHHHHHHHHHHHHHHHCT.-SS--B-HHHHHHHHHHHHH CS
  Peptidase_C1_2  57 evtnqkqsGRCWlFaalnvlRlkllkklk.lkefelsqaylffwDklEka 105
                      v +q++ G CW F+a+ vl ++l    +   ++ ls  y+   D ++ka
      EFC39696.1 148 AVRDQQTCGACWAFSATYVLAHRLCIATNgKTNVVLSPEYQVQCDTMNKA 197
                     5889******************9976665156899*****9999999887 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 5.5e-05
                     ---EEEEEEEEEE-TTSSEEEEEEE-SBTTTSTBTTEEEEE CS
  Peptidase_C1_2 358 lmtHamvltgvdvdddgkvtkwkvEnsWGedsGekGyfvms 398
                     l  Ha+ l+g  v  +  ++ w   nsWG + G  Gyf ++
      EFC39696.1 299 LGGHAVALIGWGV--ESGTNYWLAVNSWGSNWGMSGYFKIA 337
                     5569******999..4446779999*************876 PP

>> Propeptide_C1  Peptidase family C1 propeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.0   9.3e-07    0.0055       3      31 ..      75     106 ..      74     109 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 9.3e-07
                    HHHHHHHHHC.T-SEEE---..-SSBSHHHHH CS
  Propeptide_C1   3 defIdyiNsk.nttWkAgrN..Fdnttlsyik 31 
                    +e+Id+iN +   +WkA  +  F+n ++s+ +
     EFC39696.1  75 KELIDKINANeTLGWKATEYprFANLSISEAR 106
                    79********999************9999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (354 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       496  (0.0276647); expected 358.6 (0.02)
Passed bias filter:                      340  (0.0189637); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.52
# Mc/sec: 2054.52
//
Query:       EFC39697.1  [L=1223]
Description: WD40 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.9e-17   63.3   0.3    7.6e-05   23.4   0.0    5.4  4  WD40         WD domain, G-beta repeat
    0.00035   20.8   0.0        2.7    8.4   0.0    3.6  3  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.3   0.0    0.0096        86      23      38 .]     534     548 ..     523     548 .. 0.82
   2 !   15.3   0.0     3e-06     0.027       6      38 .]     557     611 ..     552     611 .. 0.77
   3 !   13.6   0.0     1e-05     0.093       2      38 .]     628     666 ..     627     666 .. 0.81
   4 !   23.4   0.0   8.5e-09   7.6e-05       8      38 .]     940     971 ..     931     971 .. 0.90

  Alignments for each domain:
  == domain 1  score: 4.3 bits;  conditional E-value: 0.0096
                 SEEEEEETTSEEEEEE CS
        WD40  23 awlasGsdDgtvriWd 38 
                 ++l ++ +Dg + +Wd
  EFC39697.1 534 PML-TCYEDGRISVWD 548
                 444.799********9 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 3e-06
                 EEESS.SSEEEEE.....................EETTSSEEEEEETTSEEEEEE CS
        WD40   6 tltGH.ssvtsla.....................fspdgawlasGsdDgtvriWd 38 
                  l GH   +t+                       + p  ++l++Gs D+++++Wd
  EFC39697.1 557 NLNGHrLTITCAVpifaqgtlisqssedsnlyfqYTPFAQFLLTGSGDKSIKLWD 611
                 56788555777777777888888877777777778888888****99*******9 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 1e-05
                 EEEEEEESS.SSEEEEE.EETTSSEEEEEETTSEEEEEE CS
        WD40   2 qclrtltGH.ssvtsla.fspdgawlasGsdDgtvriWd 38 
                 +++rt   H ssv+++   ++ ++ ++s+s Dg++ +W+
  EFC39697.1 628 NPVRTMNIHeSSVRCIElLNDGSPRFCSASNDGKICLWN 666
                 68999999*999****994444455678999*******8 PP

  == domain 4  score: 23.4 bits;  conditional E-value: 8.5e-09
                 ESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   8 tGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 ++H s +t +++ ++g+ +a+G +Dgt+r+Wd
  EFC39697.1 940 EAHsSTITTMCTLHYGHIIATGAEDGTIRLWD 971
                 489666*************************9 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.021   1.9e+02      54      86 ..     536     567 ..     495     569 .. 0.86
   2 !    5.5   0.0    0.0024        21       8      87 ..     611     687 ..     606     692 .. 0.81
   3 !    8.4   0.0    0.0003       2.7      33      67 ..     938     972 ..     910     983 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.021
  ANAPC4_WD40  54 avaysdgevrlldaesgkvvhslsvksekavtc 86 
                     y+dg++++ da + k v +l+ ++  ++tc
   EFC39697.1 536 LTCYEDGRISVWDATNSKRVANLNGHRL-TITC 567
                  5679******************998887.5877 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.0024
  ANAPC4_WD40   8 DLiAlatedgellvfRlngqrvwtleedkedsevrsLaWkpdgk.lLavaysdgevrlldaesgkvvhslsvksekavtcl 87 
                  D+ A+ +++g+   f ln  r +++    ++s+vr+++  +dg+  ++ a +dg++ l +  +g++++ ++  ++ +++ +
   EFC39697.1 611 DISAIWSTSGQAPTFNLNPVRTMNI----HESSVRCIELLNDGSpRFCSASNDGKICLWNWFTGELLQVINRREDGCISNM 687
                  5566666666666666666666666....8999*********97579**********************999999888776 PP

  == domain 3  score: 8.4 bits;  conditional E-value: 0.0003
  ANAPC4_WD40  33 eedkedsevrsLaWkpdgklLavaysdgevrllda 67 
                  ++++++s+++ ++  + g+++a + +dg++rl d 
   EFC39697.1 938 QAEAHSSTITTMCTLHYGHIIATGAEDGTIRLWDT 972
                  56788999************************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1223 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1239  (0.0691059); expected 358.6 (0.02)
Passed bias filter:                      347  (0.0193541); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.92u 0.33s 00:00:01.25 Elapsed: 00:00:00.52
# Mc/sec: 7071.51
//
Query:       EFC39698.1  [L=345]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.6e-11   41.4  11.9    1.5e-10   40.8  11.9    1.2  1  G-alpha   G-protein alpha subunit
  ------ inclusion threshold ------
        0.1   11.6   0.0       0.15   11.1   0.0    1.2  1  PhnJ      Phosphonate metabolism protein PhnJ


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.8  11.9   1.6e-14   1.5e-10     127     350 ..      49     292 ..       3     295 .. 0.71

  Alignments for each domain:
  == domain 1  score: 40.8 bits;  conditional E-value: 1.6e-14
                 -HCHHHHHHHHCCSHHHHHHHCCG.CCTT--TTHHHHHCTHHHHCSTT----CHHHHCS-----SEEEEEEECT-TEEEEEEEE-SSHHHHHGTCCCTT CS
     G-alpha 127 raevgedikaLwndpgiqelyerr.nkiklednaeyFlddleritspdYlptddDilkarlktvGisetkfevdsklefrivdvgGqrserkkWvpffd 224
                  + ++e + +Lw+  ++ e+y+++ + +++++n+e F d+++ + +   l     i+  + +t+G++    ++d +++++i++  G+r         ++
  EFC39698.1  49 PISFVELLLDLWKFRIFAEFYYENmDRFYFNENLELFVDKMRMHREDGILFDPLRII--SKETLGFTAAVKKLD-NNSITIIENRGTRPDT-----NLN 139
                 4567779999**********997779**************99888887777333443..456************.*************552.....344 PP

                 TECEEEEEEEGGGTT-B-SS-TT............SBHHHHHHHHHHCCCC-GGGT....TSEEEEEEE-HHHHHHHCCCS.-GGGCCTT--....... CS
     G-alpha 225 dvdaiiFlvslsefdqvlyedek............vnrleeslklFkeicnnkllk....ntpiiLflnKlDileeKlkkg.klskyfpsye....... 299
                   ++++ +vsl +  ++  +de+             ++++ +l+ F++i +++ lk    nt+++++++K D+l+++l+k   + ++    e       
  EFC39698.1 140 AKKVLVLTVSLVDC-MISVKDESnllnlttftsypNSKFDSALSFFEDIAKSRALKdfqqNTRVCILFTKADLLMKRLEKFeTFPRH----Ekeeckti 233
                 44445555555544.223333322333334444449999*************77664555999***************665555553....32334565 PP

                 .....H.CCH......HHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHHHHHHHH CS
     G-alpha 300 .....grknd......lesvlkylrnkFeeihkeksnnrrkiythftsatdtkevqkviesv 350
                      +   +       ++v++y+ n+F ei++++  ++ ++ +h+++a++++ev++ +e +
  EFC39698.1 234 qrneiS---NlrnffmERNVINYVVNEFYEILRKSGMESIEFDYHIINALNEEEVNRAFELI 292
                 554441...14556768999*************9999999*****************99877 PP

>> PhnJ  Phosphonate metabolism protein PhnJ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   1.6e-05      0.15      93     145 ..     120     171 ..     102     204 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 1.6e-05
        PhnJ  93 kteeatliqtrhriPeeklkedqilvlqvPipeplrvvepseaetkklhaeed 145
                 + ++ t+i  r   P+++l+++++lvl v + + +  v+ +++   +l + + 
  EFC39698.1 120 DNNSITIIENRGTRPDTNLNAKKVLVLTVSLVDCMISVKDESN-LLNLTTFTS 171
                 456789****************************999876543.333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (345 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       615  (0.034302); expected 358.6 (0.02)
Passed bias filter:                      335  (0.0186848); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.52
# Mc/sec: 2003.93
//
Query:       EFC39699.1  [L=309]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-16   59.2   7.8    8.4e-16   58.3   7.8    1.5  1  RGS             Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.023   14.4   0.7      0.049   13.4   0.5    1.7  1  TBCC            Tubulin binding cofactor C
      0.056   13.4   0.8       0.14   12.2   0.3    1.9  2  DUF5644         Family of unknown function (DUF5644)
      0.062   13.2   5.1      0.088   12.7   0.3    2.7  3  IBN_N           Importin-beta N-terminal domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.3   7.8   1.9e-19   8.4e-16       9     118 .]     130     241 ..     121     241 .. 0.92

  Alignments for each domain:
  == domain 1  score: 58.3 bits;  conditional E-value: 1.9e-19
                 HHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.....STTTTTTHHHHHHHHHHHH CS
         RGS   9 qpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke.....qpsrklfeeaqeevfelle 102
                 ++  + F eFl+se +   l+F+++v ef ++    e k+ a+ ++++y+++ s++e+ni +++re + k  ++      q s+++fe+a +ev   l+
  EFC39699.1 130 HDENESFSEFLKSECNLAPLEFYQKVTEFTTK---PEKKELARYLIKNYIKERSNSEINIANNVREVILKEYKECkhnnsQVSSNIFEKACNEVKLSLK 225
                 556789*******8888*************99...778999*************************99988887778889******************* PP

                 HHHHHHHHTSHHHHHH CS
         RGS 103 kdsypkFlkselylrl 118
                 +ds+++F+ se +++l
  EFC39699.1 226 NDSFTRFVASEQFSKL 241
                 *************875 PP

>> TBCC  Tubulin binding cofactor C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.5   1.1e-05     0.049       6      54 ..     176     224 ..     173     239 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.1e-05
                 E-S-BS-EEEE-S--S-EEEES-BS-EEE----SS-EEEES-BS-EEE- CS
        TBCC   6 isnlsdctiylldplssvtiddcknctivlgpvsgsvfiedcenctivv 54 
                 i++ s+++i + +++++v +++ k+c+   ++vs+ +f + c+++++++
  EFC39699.1 176 IKERSNSEINIANNVREVILKEYKECKHNNSQVSSNIFEKACNEVKLSL 224
                 67889****************************************9876 PP

>> DUF5644  Family of unknown function (DUF5644)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0       1.1   4.7e+03      19      30 ..     129     140 ..     113     146 .. 0.62
   2 ?   12.2   0.3   3.1e-05      0.14      11      42 ..     151     183 ..     143     187 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.1
     DUF5644  19 tkeereelekyl 30 
                 +++e e+++++l
  EFC39699.1 129 NHDENESFSEFL 140
                 356777777776 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 3.1e-05
     DUF5644  11 ffkk.aefltkeereelekylklnlitpkkndd 42 
                 f++k +ef tk e++el++yl  n+i+ ++n++
  EFC39699.1 151 FYQKvTEFTTKPEKKELARYLIKNYIKERSNSE 183
                 5655269********************999875 PP

>> IBN_N  Importin-beta N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       1.1     5e+03      51      70 ..     101     120 ..      91     121 .. 0.66
   2 ?    2.1   0.1     0.042   1.9e+02      30      64 ..     163     194 ..     150     198 .. 0.71
   3 ?   12.7   0.3     2e-05     0.088      25      73 ..     224     270 ..     204     271 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.1
                 CCHCGSXHHHHHHHHHHHHH CS
       IBN_N  51 eekqslpseekeqIrnnlln 70 
                 e  q+l  +++e  rn+++n
  EFC39699.1 101 ESPQPLERSIREMARNYVIN 120
                 34447888888888888887 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.042
                 HHHHHHHHHHHHHHHHHGGSCCCHCGSXHHHHHHH CS
       IBN_N  30 evRqlAalyLknlitkhWsdeeekqslpseekeqI 64 
                 e + lA  ++kn+i+ +  +++e  ++ ++++e I
  EFC39699.1 163 EKKELARYLIKNYIKER--SNSEI-NIANNVREVI 194
                 55678888999***999..33333.7777777665 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 2e-05
                 TTSHHHHHHHHHHHHHHHHHHHGGSCCCHCGSXHHHHHHHHHHHHHHHH CS
       IBN_N  25 seselevRqlAalyLknlitkhWsdeeekqslpseekeqIrnnllnllg 73 
                  +++  +R+ A+ ++ +li k+++  ++++sl+s++ ++I +++ +++g
  EFC39699.1 224 LKNDSFTRFVASEQFSKLILKKFN--QANKSLDSNNSTEILESIFESIG 270
                 456669****************99..4444**********999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1566  (0.0873445); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.28s 00:00:00.84 Elapsed: 00:00:00.46
# Mc/sec: 2037.23
//
Query:       EFC39700.1  [L=392]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.4e-23   80.7   0.2    1.5e-22   79.5   0.1    1.7  2  BLUF            Sensors of blue-light using FAD
    1.6e-22   80.0   1.1    2.4e-22   79.4   1.1    1.2  1  Guanylate_cyc   Adenylate and Guanylate cyclase catalytic dom
  ------ inclusion threshold ------
       0.07   12.6   0.2       0.14   11.6   0.2    1.5  1  Pneumovirus_M2  Pneumovirus matrix protein 2 (M2)


Domain annotation for each model (and alignments):
>> BLUF  Sensors of blue-light using FAD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.5   0.1   2.5e-26   1.5e-22       3      92 .]      14     107 ..      12     107 .. 0.91
   2 ?   -2.9   0.0       1.3   7.9e+03      16      31 ..     198     213 ..     194     239 .. 0.69

  Alignments for each domain:
  == domain 1  score: 79.5 bits;  conditional E-value: 2.5e-26
                 EEEEEEEE..TTS-HHHHHHHHHHHHHHHHHHTEEEEEEEETTEEEEEEEEEHHHHHHHHHHHHT-TTEEEEEEEEEEEES...S-SSTTCSSE CS
        BLUF   3 rliYvSka.aeelseeeleeileesrenNkelgitGvLlydegvflQvLEGeeeaveelyerIkkDpRhkdvevleeeeie...ersFskwsmg 92 
                 r+ YvS +    ++e+  ++il+ ++++N++++itGvL++ +++f+Q++EG+++++e+l+++I +D+Rh++v +++++  e   +r F++w+m+
  EFC39700.1  14 RIQYVSLStLGVITEKMKTKILTVATKENSKHNITGVLICVRDMFFQIIEGKTADIEQLFANIVNDSRHNNVACVDKSYFEsedDRMFPSWDMK 107
                 7899*96537788899999*********************************************************99876445899******6 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 1.3
                 HHHHHHHHHHHHHHHH CS
        BLUF  16 eeeleeileesrenNk 31 
                  ++l+ei+++sr+  +
  EFC39700.1 198 YTTLTEIISQSRSVAE 213
                 5677888888876544 PP

>> Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.4   1.1     4e-26   2.4e-22      11     182 ..     190     368 ..     182     369 .. 0.86

  Alignments for each domain:
  == domain 1  score: 79.4 bits;  conditional E-value: 4e-26
  Guanylate_cyc  11 ilFadIvgftalssahs....pievvklLnelyarfdelldekkvykvktiGdaymvvsglpeekaahaaklaelaLdmlealeevaves....ke 98 
                    ++F+d+v++t+l +  s      e+v++Ln  +a++ e+++e+++   k iGd+ m+ ++ +     + +k+++++L++le l++ + e+    ++
     EFC39700.1 190 VVFIDLVNYTTLTEIISqsrsVAEIVRILNLFFACVMEIVEEHGGDITKLIGDCVMCHFDGK-----DSQKAIDCSLKILERLDHLRYETtdpfEK 280
                    89********9998777777789************************************999.....56677777777777777777777555667 PP

  Guanylate_cyc  99 glkvrvGihtGpvvagviG..akkprydvwGntvnlAsrmestgkagkiqv..seetyellkeeqfeltergevevkG.kgkletyfle 182
                     +   +Gi++G+v++g +G   +k +y+v+G++vn+ +r++s + + +  +   e++++ l +e++ ++  g++e+kG ++++ +y +e
     EFC39700.1 281 LIYCTIGISKGEVILGNVGtvGRKLDYTVIGDSVNTSARLQSFASTTQYYLifDENVKNDLINEDYVIS-CGSIELKGkRNTVNAYTIE 368
                    8899***************77799********************9999877678999999997777665.59******55677777775 PP

>> Pneumovirus_M2  Pneumovirus matrix protein 2 (M2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.2   2.4e-05      0.14      57     110 ..      42      96 ..      27     127 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 2.4e-05
  Pneumovirus_M2  57 dsienitkasacv.alskllkelneddvkklrdnkvddskkvalynlvlsyiess 110
                     +s++nit    cv  ++  ++e +  d+ +l  n v+ds++ ++  +  sy+es+
      EFC39700.1  42 NSKHNITGVLICVrDMFFQIIEGKTADIEQLFANIVNDSRHNNVACVDKSYFESE 96 
                     6789********945999999********************************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (392 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       695  (0.038764); expected 358.6 (0.02)
Passed bias filter:                      464  (0.0258799); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.62u 0.27s 00:00:00.89 Elapsed: 00:00:00.49
# Mc/sec: 2384.03
//
Query:       EFC39701.1  [L=473]
Description: START domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00021   20.8   0.0     0.0011   18.4   0.0    2.0  1  START     START domain


Domain annotation for each model (and alignments):
>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.0   6.4e-08    0.0011      17     189 ..     260     449 ..     248     462 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 6.4e-08
                 C-TT-EEEEE.CCTTEEEEEEESSS-.SCEEEEEEEECCSCHHHHHHHHHCCCGGGTTCT-TT-SEEEEEEEECTT.......EEEEEEEE--TT..-S CS
       START  17 eeegWvllvdsengdevlqkveeskv.ksgealraigvvdmvaallveellkdaeyraqWdktlasaetvevissg.......galqlyvaelvalspl 107
                 ++ +W l++ +++g  v++++++++      a+r++g++ + +++ +e ++++  y++  ++ +++  +ve   s         +++++ + +   +++
  EFC39701.1 260 DSSVWTLEA-EKDGVSVYSRPVDNQEgGLELAFRISGLLKASVEEAFEATRNVH-YKVVQKNAIEEGRVVEDHYSTpdedgelYDIVYQRTPSPN-TYI 355
                 567899999.77777777777766653444589999999999999999999988.8888788888888776543333455777677777777777.678 PP

                 S-.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.............-TTSEE-EESSEEEEEEEECTCEEEEEEEEXEEXXSSXXHHHHHHHHH CS
       START 108 sp.RdfvflRsirelgdgsyvivdrSvtseqnppe............sssvvRaellpSgilieplgnghskvtwvehvdlkgwlpkwllrslvk 189
                  + R+f ++R+ +e  +g+ +i +rS++ ++  p+            +++ + ++   S   +e  ++  sk+ ++++++l+gw+p  l++ l+k
  EFC39701.1 356 IAkREFFSARYFTE-IEGKKLIFERSININDLAPQtlksmkkipgfnEPGAIEGTIKFSIVEFEAISETSSKFEVISKMNLNGWIPMKLINNLMK 449
                 888***********.7788889999*99887777533322222334445556666666666666666666*******************999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (473 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       504  (0.0281109); expected 358.6 (0.02)
Passed bias filter:                      380  (0.0211947); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2624.77
//
Query:       EFC39702.1  [L=428]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.16   11.9   0.0       0.33   10.8   0.0    1.5  1  Reprolysin_2  Metallo-peptidase family M12B Reprolysin-like


Domain annotation for each model (and alignments):
>> Reprolysin_2  Metallo-peptidase family M12B Reprolysin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   1.9e-05      0.33     113     135 ..     171     193 ..     147     195 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 1.9e-05
  Reprolysin_2 113 tansgsaveetkeidvvaHEvGH 135
                   t++ g++ ++ ++ d+vaHE GH
    EFC39702.1 171 TDDKGDTIYTCQSPDIVAHETGH 193
                   6899******************* PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (428 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       687  (0.0383178); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2434.43
//
Query:       EFC39703.1  [L=149]
Description: cofilin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      5e-22   78.0   0.3    5.7e-22   77.8   0.3    1.0  1  Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein


Domain annotation for each model (and alignments):
>> Cofilin_ADF  Cofilin/tropomyosin-type actin-binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.8   0.3   3.2e-26   5.7e-22       2     121 .]      11     143 ..      10     143 .. 0.92

  Alignments for each domain:
  == domain 1  score: 77.8 bits;  conditional E-value: 3.2e-26
                  HHHHHHHCTTT.....SSEEEEEEECTTTEEEEEESS-...HHHHHHHHHHTTT-EEEEEEEEEECCS........ECCEEEEEEEEE--TTS-HHHH CS
  Cofilin_ADF   2 keafkelksgk....ktkyilfkidddkeeivveeege...tyeelreelpeseprYavydveyehdd........eskrsklvfIswvPdsapikqk 84 
                  ++ ++e+++gk    ++k++++k+ ++  +i++++e +   +++el+++lp ++ r+++y++++e +         e++r+k++f++w+P+++++k+k
   EFC39703.1  11 IKSYEEMRMGKgankDKKFLVLKMHEN--SIQIDQELTklsSLDELTANLPPKNTRFICYHLSFEMPTqnensgirEGTRTKMMFLTWCPNETKVKEK 106
                  689***********999*******987..58888855566799*******************9999888899999999*************99***** PP

                  HHHHHHHHHHHHHCTTSEEEEEE-CGGCCSHHHHHHH CS
  Cofilin_ADF  85 mlyasskdalkkelkgisveieatdldelteeelkek 121
                    +a++ +++k++l+g+s +i+++ + e++e+ + ek
   EFC39703.1 107 FQVAATVKTVKEKLNGLSATIHCSVKGEIDEKLMIEK 143
                  *******************************988775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (149 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       645  (0.0359752); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.35s 00:00:00.89 Elapsed: 00:00:00.54
# Mc/sec: 833.86
//
Query:       EFC39704.1  [L=135]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.6e-16   59.3   0.1    4.5e-16   59.0   0.1    1.1  1  C2        C2 domain


Domain annotation for each model (and alignments):
>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.0   0.1   2.5e-20   4.5e-16       4      92 ..       5      96 ..       2     107 .. 0.89

  Alignments for each domain:
  == domain 1  score: 59.0 bits;  conditional E-value: 2.5e-20
                EEEEEEEESSSSSSTTSSCEEEEEEEE...ECEEEEEE-SCSSSSSSEEEEEEEEEESCHTTSEEEEEEEEECSSSTEEEEEEEEEEGHHHH CS
          C2  4 evtvieAknLpnkdkkgssdpyvkvsl...dgkqkakTrviknslnPvWnekftfevaeleeakLeveVfdndrlskddfiGkveiplstll 92
                ++  ++A+nLp+ d+ g++d+y+++++      + + T  i++ +nPvWn ++  e++ + +++++ve++d+d++++ddf+ +++i++s++l
  EFC39704.1  5 QFILHSATNLPKADVVGTIDAYAVIKIpceTCVKEYVTPFINDDENPVWNFECPSEIYMNTNDEITVEIWDKDTFTRDDFVANCQISISNIL 96
                667899*********************777777777777789999*******************************************9965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (135 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       409  (0.0228122); expected 358.6 (0.02)
Passed bias filter:                      274  (0.0152825); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.30s 00:00:00.83 Elapsed: 00:00:00.51
# Mc/sec: 789.32
//
Query:       EFC39705.1  [L=592]
Description: hypothetical protein NAEGRDRAFT_81193 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (592 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       550  (0.0306766); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.51
# Mc/sec: 3511.08
//
Query:       EFC39706.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.075   13.3   2.6       0.13   12.5   2.6    1.4  1  UPF0060   Uncharacterised BCR, YnfA/UPF0060 family


Domain annotation for each model (and alignments):
>> UPF0060  Uncharacterised BCR, YnfA/UPF0060 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   2.6   7.1e-06      0.13       4      92 ..      39     130 ..      36     144 .. 0.69

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.1e-06
     UPF0060   4 sillfllaalaeigGaylvwlwlreaksvllalvaaillavygflatlqp.aafGrvyaayGGv..fvvlallwglvvdgvkldlydwiGal 92 
                  i+l l+a l+   G  lv  +++++  v++++  +illa+yg++++ ++ a +      y  v   ++  +l   ++d+v+ + +  i  +
  EFC39706.1  39 GIMLGLIALLSLNRGFLLVNFGIKDEIIVMVGMSISILLALYGWFVSNRStAIYKSKNLIYCIVamSIADMILTKHLLDSVNFTPFTNIDLF 130
                 577778888888889999***************************99888444444444454431134444556666777766666655555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       669  (0.0373138); expected 358.6 (0.02)
Passed bias filter:                      234  (0.0130515); expected 358.6 (0.02)
Passed Vit filter:                        12  (0.000669307); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.49
# Mc/sec: 924.70
//
Query:       EFC39707.1  [L=677]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    0.00054   20.2   0.0        1.3    9.3   0.0    3.2  3  TPR_12     Tetratricopeptide repeat
    0.00089   18.8   0.4      0.002   17.7   0.4    1.5  1  SoxE       Sulfocyanin (SoxE) domain
  ------ inclusion threshold ------
      0.084   12.7   0.6         34    4.5   0.1    4.1  4  TPR_1      Tetratricopeptide repeat
       0.32   10.9   4.0       0.35   10.8   1.6    2.2  2  IQ         IQ calmodulin-binding motif


Domain annotation for each model (and alignments):
>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.0      0.62   2.8e+03      48      71 ..      85      98 ..      75      99 .. 0.61
   2 !    6.7   0.0    0.0019       8.7      14      65 ..     231     280 ..     220     297 .. 0.61
   3 !    9.3   0.0    0.0003       1.3       5      35 ..     352     382 ..     349     389 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.62
      TPR_12 48 lrnLgrlyralgryeeAlelleea 71
                l          +++ +Al+++e+ 
  EFC39707.1 85 L----------NNFGDALSFFEKY 98
                4..........4555555555554 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0019
      TPR_12  14 rrlgrydeAlellekaleiarrllGpdhpltattlrnLgrlyralgryeeAl 65 
                 +r+++y  +l + + al  ++ +  +++++ +  + n ++++ ++++y++A+
  EFC39707.1 231 MRRKKYNSSLNFAKIALKKFSHY--GNSEYSSFFYLNVATVLCLMKNYADAQ 280
                 55666666666666666666655..555556666666666666666666664 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.0003
      TPR_12   5 alnnlaavlrrlgrydeAlellekaleiarr 35 
                 a++n  ++ ++ + y++A +l+ kal+ia+ 
  EFC39707.1 352 AYHNFSLCKAHFQSYTKAVKLCTKALDIAKP 382
                 7899999*********************975 PP

>> SoxE  Sulfocyanin (SoxE) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.4   4.4e-07     0.002      20     102 ..     119     200 ..     101     218 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 4.4e-07
        SoxE  20 vvsssasnlfnfnGtsnGqlkiyiPagwsvlvklvneeslphnlvlvqnntaiPns..leissdGkillivGattsnyavsGiss 102
                 + ss a n + fnG     lkiy+  g ++ ++++n+  ++ ++ +++n+  i n+   +i +  ki     a++sn +++  s+
  EFC39707.1 119 SSSSEAINGLTFNGL---TLKIYVIIGCNLAFEYTNKGNISTAVDVLLNTFDIVNEnlKKIVKRSKIQSASRASSSNSTSRATSA 200
                 344445567777776...49******************************99987623589999999999999999977766655 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.3   0.0      0.25   1.1e+03      14      26 ..      85      97 ..      83      99 .. 0.87
   2 ?    1.9   0.0     0.049   2.2e+02       5      22 ..     143     160 ..     143     162 .. 0.88
   3 ?   -0.1   0.0      0.22   9.6e+02       4      20 ..     263     279 ..     261     281 .. 0.90
   4 ?    4.5   0.1    0.0076        34      17      30 ..     366     379 ..     364     381 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.3 bits;  conditional E-value: 0.25
                TT-HHHHHHHHHH CS
       TPR_1 14 lgkydeAleyyek 26
                l+++ +Al ++ek
  EFC39707.1 85 LNNFGDALSFFEK 97
                899*********9 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.049
                 HHHHHHHHHTT-HHHHHH CS
       TPR_1   5 ynlGnayfklgkydeAle 22 
                 +nl+  y ++g+   A++
  EFC39707.1 143 CNLAFEYTNKGNISTAVD 160
                 799********9998875 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.22
                 HHHHHHHHHHTT-HHHH CS
       TPR_1   4 lynlGnayfklgkydeA 20 
                 + n + ++  +++y +A
  EFC39707.1 263 YLNVATVLCLMKNYADA 279
                 8899999*******999 PP

  == domain 4  score: 4.5 bits;  conditional E-value: 0.0076
                 HHHHHHHHHHHHHH CS
       TPR_1  17 ydeAleyyekALel 30 
                 y +A++ + kAL +
  EFC39707.1 366 YTKAVKLCTKALDI 379
                 89**********98 PP

>> IQ  IQ calmodulin-binding motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0      0.47   2.1e+03       6      13 ..     181     188 ..     180     188 .. 0.86
   2 ?   10.8   1.6   7.8e-05      0.35       2      19 ..     622     639 ..     621     640 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.47
                 HHHHHHHH CS
          IQ   6 kIQaawRG 13 
                 kIQ+a R+
  EFC39707.1 181 KIQSASRA 188
                 8***9995 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 7.8e-05
                 HHHHHHHHHHHHHHHHHH CS
          IQ   2 kaaikIQaawRGylaRkr 19 
                 +a+ik Q ++R  laRkr
  EFC39707.1 622 QAVIKVQQFFRKVLARKR 639
                 79***************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (677 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2385  (0.133025); expected 358.6 (0.02)
Passed bias filter:                      554  (0.0308997); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.78u 0.32s 00:00:01.10 Elapsed: 00:00:00.49
# Mc/sec: 4113.76
//
Query:       EFC39708.1  [L=451]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-36  126.1   0.2    2.6e-36  125.1   0.2    1.5  1  MT-A70    MT-A70
  ------ inclusion threshold ------
      0.014   16.0   2.4      0.014   16.0   2.4    2.9  3  CDRT4     CMT1A duplicated region transcript 4 protein
       0.38   10.8  30.4        2.3    8.2   1.7    2.4  2  YL1       YL1 nuclear protein
        2.5    7.3  37.7       0.37   10.1   3.4    2.2  2  BUD22     BUD22
        4.4    7.4  31.9       0.72    9.9   3.4    2.8  3  NST1      Salt tolerance down-regulator


Domain annotation for each model (and alignments):
>> MT-A70  MT-A70
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  125.1   0.2   7.2e-40   2.6e-36       1     172 []     272     450 ..     272     450 .. 0.89

  Alignments for each domain:
  == domain 1  score: 125.1 bits;  conditional E-value: 7.2e-40
                 ECEEEE---BHHCC..HTT..--SS--B-HHHHHTS-GGGCECC.EEEEEEEEETTCHHHHHHHHHHHCT-EEEEEEEEEEE-TTSCBS-BS-TTSSSB CS
      MT-A70   1 fdviiidPpweeklvarkk..elpyktlneeelkaLpipelldk.rslvflWvtnrellelkrellkkWglelveeltwlkinklgepiatlesgavlk 96 
                 fdvi++dPpw+  + +  +   + yk l++++++ ++i++l++k ++++f+Wv n +  ++  e+++kWg++ v+e+tw+k +k+ ++ +    g  l+
  EFC39708.1 272 FDVILMDPPWQLATSNPLRgvAISYKPLSDKHIQSMDISSLQEKnGGFLFVWVINAKYVKT-LEMIEKWGYKFVDEITWVKQTKHRRLAK--GHGYYLQ 367
                 9**********99966555889********************99899********999999.9********************5555554..67899** PP

                 B-EEEEEEEEES---TTT.TTB-TTS.....SBSEEEEE-CTTTSS-THHHHHHHHHCTCS-EEEET--G..--TTEEEEETT CS
      MT-A70  97 kskEhllvgvkgnvkrstdkiinknv.....dtdliisperehsrKPpelfellehllesarkLelFaRs..lrpgwltvGne 172
                 ++kE++++++k ++ +  ++++++        +d+i+s +r++s+KP+ l++ +e+++++ + Le+F+R   lr+ w+t+Gne
  EFC39708.1 368 HAKENCIIAIKNTTPEREKEMMEAARqkvtsLCDVILSDRRGQSQKPEDLYHFIEQMVPDGKYLEIFGRRnnLRDYWVTIGNE 450
                 ***********99877766655444334566789***********************************999*********97 PP

>> CDRT4  CMT1A duplicated region transcript 4 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   8.2       2.9   1.1e+04      44     112 ..      39     109 ..      23     133 .. 0.59
   2 ?   16.0   2.4   3.8e-06     0.014      16     116 ..     159     260 ..     151     269 .. 0.81
   3 ?   -1.9   0.1       1.4   4.9e+03      55      74 ..     367     386 ..     344     415 .. 0.55

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 2.9
       CDRT4  44 lkaleesrreskqnkkssiiqlkrrkss...kssa.elvlkdtlsetmlsvwesysvlavgptvvPeptllqt 112
                   ++++++ ++ +nk+ s +  +r+k+s    +sa   + + ++ +t  s  +s s+++ ++ ++ +  ++++
  EFC39708.1  39 S-SSDDDESNNSKNKRKSRVSSSRSKPSlslTTSAsSSSTRKQQQQTKQSNSSS-STSSSSSRIIRRISNHHV 109
                 3.3444455555566666667788887622222320333444445555555444.556666666665555554 PP

  == domain 2  score: 16.0 bits;  conditional E-value: 3.8e-06
       CDRT4  16 dpWPayvtytspvvkrliekskareleclkaleesrreskqnkkssiiq.lkrrksskssaelvlkdtlsetmlsvwesysvlavgptvvPeptllqtd 113
                 d    y  y s+v   l+ ++   e  c+++ e++++e++++ +ss       ++s+++s+  +l d  se   + + s  ++ + +t+  + + ++td
  EFC39708.1 159 DEVSPYLKYPSSVLLMLLQHQESEEQHCAEEEEKKKKEKRKKSSSSKSSnSVDKRSAEFSSSSTLNDGDSELDSTALPSEPIMLTESTIPKHCVPIRTD 257
                 55566999**********************99999998877766665441445789**************99999999988777777776677778888 PP

       CDRT4 114 sre 116
                 +r+
  EFC39708.1 258 VRN 260
                 886 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.4
       CDRT4  55 kqnkkssiiqlkrrksskss 74 
                 ++ k+  ii +k   +++  
  EFC39708.1 367 QHAKENCIIAIKNTTPEREK 386
                 55555555555554444333 PP

>> YL1  YL1 nuclear protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6  21.2     0.001       3.7      32     185 ..      14     146 ..      11     157 .. 0.51
   2 ?    8.2   1.7   0.00065       2.3      63      98 ..     180     215 ..     174     262 .. 0.55

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.001
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1  32 edDeefeseeeeeeeensDsdfdsdeedeesdeeedeeegekelerqerkkrkkekkkrkaqkkkskkkkkkqkkkkkkkidpqakeprpkkkserasw 130
                  dDe++e++e +++   s+    s++  e s++++de+++ k     +rk r   +  r +++ + +++ ++++++k++         ++ k+s+ +s 
  EFC39708.1  14 SDDEDYEENEPQQKH-YSE----SSSASEYSSSDDDESNNSK----NKRKSR--VSSSRSKPSLSLTTSASSSSTRKQQ---------QQTKQSNSSSS 92 
                 69*****99888776.466....4444445666666655544....444444..2344445666777777666666666.........33333332222 PP

                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxx RF
         YL1 131 lpaeslltpkrRkssRastvenkeqleerlkereerrkkile.rmrkkaarkkkkk 185
                 +++ s+ +   R+ s  ++ ++++   e lk+   +r++i     +k++ ++++ +
  EFC39708.1  93 TSS-SS-SRIIRRISNHHVKKHQAVDWEVLKQILVKRRQIYDlELKKAQLEREASR 146
                 222.22.2234666666655444444444555544444444424444444444433 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00065
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
         YL1  63 deeedeeegekelerqerkkrkkekkkrkaqkkksk 98 
                 ++ee+  ++e+e +++e++k+ +++k +++ +k s+
  EFC39708.1 180 ESEEQHCAEEEEKKKKEKRKKSSSSKSSNSVDKRSA 215
                 233333333333223333333222222222222222 PP

>> BUD22  BUD22
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0  26.4     0.015        53     192     283 ..      12      96 ..       5     101 .. 0.57
   2 ?   10.1   3.4    0.0001      0.37     136     285 ..     177     233 ..     104     276 .. 0.50

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.015
       BUD22 192 eeeededdedaeedeedeeaeerelaqydgllasddededeyneetdeesseesdssdssesasesesessekkkkkkkkkkkkakakkvts 283
                 ++++ded e+ e  +++  +e+ ++++y    +s+d+de+ +n++++ +s+ +s++s++s s   s s+ss++ k+++++k++++++++++s
  EFC39708.1  12 SSSDDEDYEENE-PQQKHYSESSSASEY----SSSDDDES-NNSKNKRKSRVSSSRSKPSLSLTTSASSSSTR-KQQQQTKQSNSSSSTSSS 96 
                 333333333222.233334444444444....35555555.48999999999999999999999999988888.444444444444433333 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.0001
       BUD22 136 giekkkkkkeeekkkkkkkkkkkkkkeeeeeeesdkeeesedsedeekeeseddeeeeeededdedaeedeedeeaeerelaqydgllasddededeyn 234
                 + ++                                                                                             ++
  EFC39708.1 177 QHQE---------------------------------------------------------------------------------------------SE 182
                 2111.............................................................................................11 PP

       BUD22 235 eetdeesseesdssdssesasesesessekkkkkkkkkkkkakakkvt.sst 285
                 e++  e++e+++++++++s s+++s+s + k++++ +++++ +   ++ +st
  EFC39708.1 183 EQHCAEEEEKKKKEKRKKSSSSKSSNSVD-KRSAEFSSSSTLNDGDSElDST 233
                 11111111111111111111111111111.1222222222222222222333 PP

>> NST1  Salt tolerance down-regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3  19.4     0.022        80       8     101 ..      20     111 ..      11     150 .. 0.55
   2 ?    9.9   3.4    0.0002      0.72      19      68 ..     178     227 ..     174     251 .. 0.64
   3 ?   -2.1   0.0      0.98   3.5e+03     107     119 ..     437     449 ..     434     450 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.022
        NST1   8 nsqeqqqqqqdknevdeksqvesskrkkkkkkkkknrsnsnnqneesstslstsksvaittssarsvknnppsvssaalrsakkvskdrsiwnt 101
                  ++e qq++  +++ +++ + +  ++ ++ k+k+k+r++s   + + s  +s+s+s + +++++   +n+++s+ss+++r  +++s+ +   ++
  EFC39708.1  20 EENEPQQKHYSESSSASEYSSSDDDESNNSKNKRKSRVSSSRSKPSLSLTTSASSSSTRKQQQQTKQSNSSSSTSSSSSRIIRRISNHH--VKK 111
                 22222222222222222222233333344445566777776666666666666665565555555555556666666666666655544..333 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0002
        NST1  19 knevdeksqvesskrkkkkkkkkknrsnsnnqneesstslstsksvaitt 68 
                 ++e +e++  e++++kkk+k+kk + s+s n  +++s + s s++     
  EFC39708.1 178 HQESEEQHCAEEEEKKKKEKRKKSSSSKSSNSVDKRSAEFSSSSTLNDGD 227
                 33334444444555555555566677778888888888888888665544 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.98
        NST1 107 reklkeFWlsLgE 119
                 r++l+++W+ +g+
  EFC39708.1 437 RNNLRDYWVTIGN 449
                 89*******9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2755  (0.153662); expected 358.6 (0.02)
Passed bias filter:                      550  (0.0306766); expected 358.6 (0.02)
Passed Vit filter:                       138  (0.00769703); expected 17.9 (0.001)
Passed Fwd filter:                        58  (0.00323498); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.19u 0.37s 00:00:01.56 Elapsed: 00:00:00.54
# Mc/sec: 2524.78
//
Query:       EFC39709.1  [L=600]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.2e-86  281.8  37.6    1.2e-11   44.1   0.1   14.5 13  DUF4116   Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
      0.075   12.7   0.5       0.22   11.2   0.5    1.9  1  HBB       Helical and beta-bridge domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.9   0.0   2.5e-13   2.2e-09       2      49 .]      10      56 ..       9      56 .. 0.92
   2 !   43.8   0.0   1.7e-15   1.5e-11       1      49 []      33      81 ..      33      81 .. 0.99
   3 !   31.1   0.0   1.5e-11   1.4e-07       1      45 [.      83     127 ..      83     132 .. 0.94
   4 !   33.5   0.0   2.8e-12   2.5e-08       1      35 [.     133     167 ..     133     190 .. 0.74
   5 !    3.5   0.1    0.0064        57       4      39 ..     182     218 ..     179     222 .. 0.65
   6 !   14.2   4.3   3.1e-06     0.028       2      42 ..     228     268 ..     227     315 .. 0.90
   7 !   24.6   0.2   1.7e-09   1.5e-05       1      31 [.     333     363 ..     333     371 .. 0.94
   8 !    8.8   0.0   0.00015       1.4      15      34 ..     371     390 ..     364     392 .. 0.86
   9 !   18.4   0.0   1.5e-07    0.0014      18      36 ..     397     415 ..     390     416 .. 0.84
  10 !   44.1   0.1   1.4e-15   1.2e-11       1      48 [.     405     451 ..     405     452 .. 0.96
  11 !   43.6   0.9   1.9e-15   1.7e-11       1      38 [.     454     492 ..     454     499 .. 0.90
  12 !   28.7   0.1   9.1e-11   8.2e-07       2      49 .]     480     533 ..     480     533 .. 0.91
  13 !   25.4   0.8   9.4e-10   8.4e-06       1      39 [.     506     548 ..     506     574 .. 0.92

  Alignments for each domain:
  == domain 1  score: 36.9 bits;  conditional E-value: 2.5e-13
     DUF4116  2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                rE+vl+avkkng+ l +   ++ +D+eiv++A++qng+ l ya  eLr
  EFC39709.1 10 RELVLQAVKKNGNDLMK-YQKFNSDREIVIAAIRQNGNGLFYAGVELR 56
                9************6666.678889*******************99998 PP

  == domain 2  score: 43.8 bits;  conditional E-value: 1.7e-15
     DUF4116  1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49
                DrEiv  a+++ng+ l y+  eL+nD+e+v + +k n + ++y+s+eL+
  EFC39709.1 33 DREIVIAAIRQNGNGLFYAGVELRNDREVVRESMKVNQHTFYYMSDELK 81
                9**********************************************97 PP

  == domain 3  score: 31.1 bits;  conditional E-value: 1.5e-11
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 Dr ++leavk  + +++y++ e+knD+ ++ +A   ng++l +++
  EFC39709.1  83 DRSLALEAVKEIPGSIRYAPGEIKNDRSFIVEAALLNGKVLQFLD 127
                 899****************************************97 PP

  == domain 4  score: 33.5 bits;  conditional E-value: 2.8e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvk 35 
                 DrEiv +av+++g+a+ky++ee+++D  ++l  ++
  EFC39709.1 133 DREIVENAVSQYGYAIKYAPEEFQRDESLMLGVIR 167
                 9**************************99776555 PP

  == domain 5  score: 3.5 bits;  conditional E-value: 0.0064
     DUF4116   4 ivleavkkn...gsalkylseeLknDkeivlkAvkqngt 39 
                 ++l++vk +    +a+k   e+ +n ke++l A+++ng+
  EFC39709.1 182 LILKYVKEHnggYLAIKL--ERCCNVKEVILGALENNGS 218
                 566666633222224444..6778899999999999997 PP

  == domain 6  score: 14.2 bits;  conditional E-value: 3.1e-06
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtals 42 
                 rE++l  +k n++++++++e++kn k++  kA   n+t+l+
  EFC39709.1 228 REFILDMLKENWEIFEKADENIKNEKQVYTKAFGLNCTFLE 268
                 9***********************99999999999999874 PP

  == domain 7  score: 24.6 bits;  conditional E-value: 1.7e-09
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivl 31 
                 Dr++vl+av  + ++l ++s++Lk D++++ 
  EFC39709.1 333 DRDFVLQAVYLDEKYLSFASDSLKDDFDFMV 363
                 9****************************95 PP

  == domain 8  score: 8.8 bits;  conditional E-value: 0.00015
     DUF4116  15 alkylseeLknDkeivlkAv 34 
                 + + +s++Lk+D +++l+A+
  EFC39709.1 371 NMRDASPRLKSDPQFILRAL 390
                 67889*************97 PP

  == domain 9  score: 18.4 bits;  conditional E-value: 1.5e-07
     DUF4116  18 ylseeLknDkeivlkAvkq 36 
                 ++++eL+ D+++++kAv++
  EFC39709.1 397 KAPKELRADRDFMMKAVQK 415
                 49***************96 PP

  == domain 10  score: 44.1 bits;  conditional E-value: 1.4e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 Dr+++++av+k g +l+++s++LknDke+vl A+k + +++s+as+ L
  EFC39709.1 405 DRDFMMKAVQK-GTHLYHASDDLKNDKELVLTAIKGSYSNISHASKGL 451
                 9**********.9*******************************9855 PP

  == domain 11  score: 43.6 bits;  conditional E-value: 1.9e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkq.ng 38 
                 DrE++ e++k++g++lkyls+++knD+e++l A ++ n+
  EFC39709.1 454 DREFIIEVLKIDGNCLKYLSKSFKNDRELILTAAQSiNP 492
                 9*******************************9984255 PP

  == domain 12  score: 28.7 bits;  conditional E-value: 9.1e-11
     DUF4116   2 rEivleavkkngsalky..lseeLknDkeivlkAvkqngtal....syaseeLr 49 
                 rE++l a ++ + ++ y  + e +  D+e+++++ kq+g+ +    sy+s+e+r
  EFC39709.1 480 RELILTAAQSINPYIDYelCYELFPTDREVMMECTKQYGYEMipynSYLSDEFR 533
                 8**********999999878*******************9666669*****998 PP

  == domain 13  score: 25.4 bits;  conditional E-value: 9.4e-10
     DUF4116   1 DrEivleavkkngs....alkylseeLknDkeivlkAvkqngt 39 
                 DrE+++e+ k++g+    +  yls+e++ Dke++ ++  +n +
  EFC39709.1 506 DREVMMECTKQYGYemipYNSYLSDEFRFDKEFMFQIAASNNS 548
                 9************998888888**************9887765 PP

>> HBB  Helical and beta-bridge domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.5   2.5e-05      0.22     103     140 ..     320     356 ..     212     357 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.5e-05
                 TS.TTTEEEEEE.STT.EECCCCS-TCCHHHHHHHCHC CS
         HBB 103 ssdeedYvrlvskeegesLeavcldPskalrflkerls 140
                 + + ++Y++ +s+++++ L+av+ld  k l+f +++l+
  EFC39709.1 320 DDQIHEYLHHFSSDRDFVLQAVYLD-EKYLSFASDSLK 356
                 344579*******************.******999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (600 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       715  (0.0398795); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.48
# Mc/sec: 3765.66
//
Query:       EFC39710.1  [L=393]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     0.0042   16.7   6.9     0.0079   15.8   6.9    1.5  1  DUF2968       Protein of unknown function (DUF2968)
     0.0057   16.5   0.5     0.0057   16.5   0.5    2.1  2  MCPsignal     Methyl-accepting chemotaxis protein (MCP) signa
     0.0098   15.8   1.1     0.0098   15.8   1.1    2.3  3  Phage_Mu_Gam  Bacteriophage Mu Gam like protein
  ------ inclusion threshold ------
       0.06   13.8   0.5       0.06   13.8   0.5    3.0  3  FlaC_arch     Flagella accessory protein C (FlaC)
      0.085   12.9  14.4      0.067   13.2   3.5    2.3  2  Laminin_II    Laminin Domain II
       0.38   10.3   6.3       0.56    9.7   6.3    1.2  1  Exonuc_VII_L  Exonuclease VII, large subunit
        1.2    9.7   5.2       0.72   10.4   0.7    2.5  2  SLED          SLED domain
        1.9    8.6   7.5       0.56   10.3   0.7    2.5  2  zf-CRD        Cysteine rich domain with multizinc binding reg
          4    6.2   8.4         11    4.8   8.6    1.7  1  LMBR1         LMBR1-like membrane protein
        8.5    6.7   8.9        1.8    8.9   1.6    2.4  2  DUF948        Bacterial protein of unknown function (DUF948)


Domain annotation for each model (and alignments):
>> DUF2968  Protein of unknown function (DUF2968)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   6.9   4.4e-06    0.0079     107     179 ..     137     207 ..     103     208 .. 0.80

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 4.4e-06
     DUF2968 107 qkaqlerqiaasearaerLqadlavarqQeqavaerQkqarkeaaaLeaqreaaqaqlralqrqirqLqaqqe 179
                 +k +l ++ia +++    L++ ++++++Q ++v + Q++  +e++aL+++ +++q+ l+++  ++r+L+++ +
  EFC39710.1 137 DKLHLSNLIAGTSK--DILEKIIEIKKDQSEEVRKLQHSNETETKALDTKLDKMQKSLDDVVDEVRKLDEKMN 207
                 55555555555444..34777899********************************************99876 PP

>> MCPsignal  Methyl-accepting chemotaxis protein (MCP) signalling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.2      0.47   8.5e+02     138     168 ..      87     117 ..      69     124 .. 0.73
   2 !   16.5   0.5   3.2e-06    0.0057      86     149 ..     147     211 ..     136     218 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.47
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   MCPsignal 138 aevadlvqeiaaaseeqsasieevnqaveev 168
                 + v++l++e+    ++qs  i+ +nq  e+ 
  EFC39710.1  87 KTVKSLMREMMLILSDQSDNIKIMNQHAEHH 117
                 2477788888888888888888888877765 PP

  == domain 2  score: 16.5 bits;  conditional E-value: 3.2e-06
                 HHHHHHHHHH..............HHHHH.HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH CS
   MCPsignal  86 qaakeiealiieiqkeindsvesleetrq.rveegselveetgealkeiveavaevadlvqeiaa 149
                  ++k+i + iiei+k+  + v+ l+++++ +++   ++ ++ +++l ++v++v ++++ ++++ +
  EFC39710.1 147 GTSKDILEKIIEIKKDQSEEVRKLQHSNEtETKALDTKLDKMQKSLDDVVDEVRKLDEKMNNLHV 211
                 56899999999*************999861555556789***********************976 PP

>> Phage_Mu_Gam  Bacteriophage Mu Gam like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.7       0.9   1.6e+03      13      65 ..      91     121 ..      66     137 .. 0.54
   2 !   15.8   1.1   5.5e-06    0.0098      12      90 ..     150     225 ..     143     243 .. 0.91
   3 ?   -3.1   0.0       3.5   6.4e+03      51      71 ..     273     293 ..     252     302 .. 0.49

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.9
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCTHHHH CS
  Phage_Mu_Gam  13 elkreleeieaeaneeiaaikekleaeleplkkeieylesllkqYaeankdeL 65 
                    l re+  i ++  ++i+ ++                      q ae++k+ +
    EFC39710.1  91 SLMREMMLILSDQSDNIKIMN----------------------QHAEHHKQRI 121
                   444444444444444444443......................2222222222 PP

  == domain 2  score: 15.8 bits;  conditional E-value: 5.5e-06
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCTHHHH-..-----EE-SS-EE--------- CS
  Phage_Mu_Gam  12 aelkreleeieaeaneeiaaikekleaeleplkkeieylesllkqYaeankdeLfkdgktKslklpfGkvgfrkstpkv 90 
                   +++ +++ ei+++  ee+ ++++  e+e+++l+++ +++++ l   +++ + +L  d+k   l + + +++f+ +++k 
    EFC39710.1 150 KDILEKIIEIKKDQSEEVRKLQHSNETETKALDTKLDKMQKSLDDVVDEVR-KL--DEKMNNLHVLYSELKFKGNPSKP 225
                   56778999*******************************************.66..69999***********9988875 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 3.5
                   HHHHHHHHHCTHHHH-..--- CS
  Phage_Mu_Gam  51 esllkqYaeankdeLfkdgkt 71 
                    +l+ + + +n+  +  ++kt
    EFC39710.1 273 INLIGEQCNSNQTYINFKTKT 293
                   333333333333333333333 PP

>> FlaC_arch  Flagella accessory protein C (FlaC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.1      0.85   1.5e+03      31      41 ..      83      93 ..      81      97 .. 0.87
   2 ?   -0.7   0.4       1.1   1.9e+03      13      36 ..     104     127 ..      93     136 .. 0.72
   3 ?   13.8   0.5   3.3e-05      0.06       6      44 ..     175     213 ..     172     222 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.85
   FlaC_arch 31 eelkenVkdll 41
                e+++++Vk l+
  EFC39710.1 83 EMVEKTVKSLM 93
                79999999998 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.1
   FlaC_arch  13 steletvkkeneelsksveelken 36 
                 s +++ + +  e+ ++ +e+l+++
  EFC39710.1 104 SDNIKIMNQHAEHHKQRIEKLEDQ 127
                 556667777778888888888764 PP

  == domain 3  score: 13.8 bits;  conditional E-value: 3.3e-05
   FlaC_arch   6 EnklsklsteletvkkeneelsksveelkenVkdllsLY 44 
                 E++ + l+t+l+ ++k+++++ ++v +l+e+ ++l  LY
  EFC39710.1 175 ETETKALDTKLDKMQKSLDDVVDEVRKLDEKMNNLHVLY 213
                 778889**************************9998888 PP

>> Laminin_II  Laminin Domain II
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   3.8     0.011        21      37      99 ..      82     145 ..      69     150 .. 0.81
   2 ?   13.2   3.5   3.7e-05     0.067      10      97 ..     147     237 ..     142     248 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.011
                 XXXXXXXXXXXX.XXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH...HHHHHHHHHHHH CS
  Laminin_II  37 nrsveetnekvk.dankairdArrsvkkLeklapqLldklkelkqleeassslsdniseikelI 99 
                 ++ ve+t + +  +++ ++ d ++++k +++ a+   +++++l+ +++  + ls++   + +lI
  EFC39710.1  82 EEMVEKTVKSLMrEMMLILSDQSDNIKIMNQHAEHHKQRIEKLEDQQVILEMLSQDKLHLSNLI 145
                 5667777776663777788999************************999888888755555555 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 3.7e-05
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXX--TTTTTGGGHHHHHHHHHH.....HHHHHHHHHH CS
  Laminin_II  10 etakevleqlaplsqnlentkeklseinrs.veetnekvkdankairdArrsvkkLeklapqLldklkelkqleeasss..lsdniseike 97 
                  t k +le++ +++++ +++  kl++ n++  +  + k+++++k ++d+ ++v+kL++++++L    +elk + ++s+   ls  + + ke
  EFC39710.1 147 GTSKDILEKIIEIKKDQSEEVRKLQHSNETeTKALDTKLDKMQKSLDDVVDEVRKLDEKMNNLHVLYSELKFKGNPSKPsmLSTFLGRGKE 237
                 5667777888888888877777777777661334567888999********************9999999999988765677777766666 PP

>> Exonuc_VII_L  Exonuclease VII, large subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   6.3   0.00031      0.56     129     256 ..      76     216 ..      71     249 .. 0.53

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00031
  Exonuc_VII_L 129 pTPtaaAelvvpdkaeleeqleeler...rlekaikrlleekkqrleklasrlkspeellerkrqrldeleerleralkkq.lkkkrerleelkerl 221
                    TP  + e+v +  + l +++  + +      k ++++ e++kqr+ekl+ +     e+l++++ +l++l +  ++ + ++ ++ k+ + ee++ +l
    EFC39710.1  76 VTPNLVEEMVEKTVKSLMREMMLILSdqsDNIKIMNQHAEHHKQRIEKLEDQQ-VILEMLSQDKLHLSNLIAGTSKDILEKiIEIKKDQSEEVR-KL 170
                   56666666666555444333322222000233456677788888888886544.3567777777888777766666655553333333333333.33 PP

  Exonuc_VII_L 222 k....ekleekkerlkklkerle.......lleekkerleeleekl 256
                   +    +++++ +++l+k++++l+       +l+ek ++l+ l ++l
    EFC39710.1 171 QhsneTETKALDTKLDKMQKSLDdvvdevrKLDEKMNNLHVLYSEL 216
                   2133355555556666666666633332224555555554444444 PP

>> SLED  SLED domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.3      0.53   9.6e+02      33      86 ..      85     125 ..      73     146 .. 0.51
   2 ?   10.4   0.7    0.0004      0.72      37     102 ..     149     216 ..     142     219 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.53
        SLED  33 vslvlkevlqalvnaaykpkqvlklLkkgeggeveiitakiegkshtvklpvve 86 
                 v++ +k ++ +++ +  +++  +k +++++             + h+++++ +e
  EFC39710.1  85 VEKTVKSLMREMMLILSDQSDNIKIMNQHA-------------EHHKQRIEKLE 125
                 444445555555555555555555555544.............23333333333 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.0004
        SLED  37 lkevlqalvnaaykpkqvlklLkkgeggeveiitakieg..kshtvklpvvesakevadfleklcekl 102
                  k++l++++++++++++ +++L+  +++e++ + +k+++  ks  + +  v++ +e  + l+ l ++l
  EFC39710.1 149 SKDILEKIIEIKKDQSEEVRKLQHSNETETKALDTKLDKmqKSLDDVVDEVRKLDEKMNNLHVLYSEL 216
                 699***********************99999****999877888888888888777777777666665 PP

>> zf-CRD  Cysteine rich domain with multizinc binding regions
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.1   1.2      0.22   3.9e+02      79     130 ..      64     118 ..      50     145 .. 0.65
   2 ?   10.3   0.7   0.00031      0.56      66     118 ..     153     206 ..     141     229 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.1 bits;  conditional E-value: 0.22
      zf-CRD  79 eevlegneveqkilkdylaek.gltlqdvlkevlekldkge..lkrtrkklnlse 130
                  + +++n+ ++ ++ + ++e+ ++t++++++e++  l++++  +k ++++ ++++
  EFC39710.1  64 YNQYKENRDQSIVTPNLVEEMvEKTVKSLMREMMLILSDQSdnIKIMNQHAEHHK 118
                 5555556655555555555543678888888888888766633333444433333 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00031
      zf-CRD  66 Lkpi..eekliekipeevlegneveqkilkdylaekgltlqdvlkevlekldkge 118
                 L++i   +k +++  +++ ++ne+e+k l++ l +++++l+dv++e ++kld++ 
  EFC39710.1 153 LEKIieIKKDQSEEVRKLQHSNETETKALDTKLDKMQKSLDDVVDE-VRKLDEKM 206
                 554444345555666788999***********************99.67887665 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.8   8.6    0.0062        11     193     244 ..     158     213 ..      63     304 .. 0.72

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0062
       LMBR1 193 eiksdldeelkkly....feaaklntekeeaereledllkevkklrksisesdplr 244
                 eik+d +ee +kl+    +e + l+t+++++++ l+d+++ev+kl++++++ + l+
  EFC39710.1 158 EIKKDQSEEVRKLQhsneTETKALDTKLDKMQKSLDDVVDEVRKLDEKMNNLHVLY 213
                 5666666666666522236888999************************9999422 PP

>> DUF948  Bacterial protein of unknown function (DUF948)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   1.0      0.17   3.1e+02      31      71 ..      85     125 ..      79     142 .. 0.80
   2 ?    8.9   1.6   0.00099       1.8      32      77 ..     164     209 ..     149     216 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.17
      DUF948  31 aaatieelekqvdpilkevedllakvnelledvneklekvd 71 
                 +++t+++l++++  il +  d ++ +n+ +e  ++++ek++
  EFC39710.1  85 VEKTVKSLMREMMLILSDQSDNIKIMNQHAEHHKQRIEKLE 125
                 67899999999999999999999888888888888888776 PP

  == domain 2  score: 8.9 bits;  conditional E-value: 0.00099
      DUF948  32 aatieelekqvdpilkevedllakvnelledvneklekvdplteav 77 
                 ++ +++l++  +  +k +++ l+k+++ l+dv +++ k+d+ ++++
  EFC39710.1 164 SEEVRKLQHSNETETKALDTKLDKMQKSLDDVVDEVRKLDEKMNNL 209
                 5678888888888888999999999999999999999999887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (393 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2367  (0.132021); expected 358.6 (0.02)
Passed bias filter:                      648  (0.0361426); expected 358.6 (0.02)
Passed Vit filter:                        75  (0.00418317); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.76u 0.36s 00:00:01.12 Elapsed: 00:00:00.56
# Mc/sec: 2129.50
//
Query:       EFC39711.1  [L=732]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.9e-05   24.3   0.0    4.8e-05   23.0   0.0    1.7  1  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
    7.2e-05   23.0   2.9    0.00014   22.2   1.1    2.4  3  RGS       Regulator of G protein signaling domain
    8.5e-05   23.1   0.1       0.74   10.5   0.0    2.5  2  RCC1      Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.083   12.5   0.3       0.14   11.8   0.3    1.3  1  DUF5023   Domain of unknown function (DUF5023)


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   1.1e-08   4.8e-05       1      30 []     244     273 ..     244     273 .. 0.94

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 1.1e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +k+vs+G++H ++L+e+G V++ G N + Q
  EFC39711.1 244 IKKVSSGYRHCVVLLENGQVFTRGFNYHNQ 273
                 79********************99998877 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.5   6.8e+03       5      30 ..     182     209 ..     177     211 .. 0.72
   2 ?   -2.5   0.0       1.4   6.1e+03      61      92 ..     405     435 ..     388     444 .. 0.70
   3 !   22.2   1.1     3e-08   0.00014       2     114 ..     603     723 ..     602     726 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.5
                 HHTSHHHHHHHHHHHHHTTCT..HHHHH CS
         RGS   5 lledqpgrslFreFlesefse..enlsF 30 
                 +++d++ ++lF  F+++ +    en +F
  EFC39711.1 182 VIDDPSPVKLFSCFCRDLQIIvlENNKF 209
                 567788999*****99865444555555 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.4
                 TSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHH CS
         RGS  61 sspkelnidkklreelekrlekeqpsrklfee 92 
                  + ++  id+kl +++    ++ ++s + + +
  EFC39711.1 405 TARRKRRIDSKLASTVSISTNQ-KKSVSFYSK 435
                 4445668888888887777777.555555555 PP

  == domain 3  score: 22.2 bits;  conditional E-value: 3e-08
                 HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS..........STTTTTT CS
         RGS   2 leslledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke..........qpsrklf 90 
                 +++ll++   r+++r + ++e+s enl++++  e+++k+     ++k   eI  +y+++ +p e+n++++ r +  + le e            +r+l+
  EFC39711.1 603 IQKLLKETEFREMLRVYSRNEHSIENLALYEVLEQIRKS--GVVTHKNLLEIHHNYIQMFAPFEINLSSDGRFKFMELLEREanvpysdldeIIMRELL 699
                 789************************************..7778888**************************9999999988888888887888888 PP

                 HHHHHHHHHHHHHHHHHHHHTSHH CS
         RGS  91 eeaqeevfellekdsypkFlksel 114
                  ++ + + +l  ++ y+++l++++
  EFC39711.1 700 INLTDTISRLETTSEYEDWLETKK 723
                 888888888888888888888776 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0   0.00023         1      24      50 .]     230     257 ..     214     257 .. 0.81
   2 !   10.5   0.0   0.00017      0.74       1      35 [.     260     307 ..     260     320 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00023
                 EEEEE-GGGTTS.-EEEEEEETTEEEEE CS
        RCC1  24 lvPtkveglsgn.rvvkvacGddhtval 50 
                 +vP++v+++  n  ++kv++G++h+v+l
  EFC39711.1 230 DVPVEVATPLFNsGIKKVSSGYRHCVVL 257
                 78****9988888************986 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.00017
                 TTEEEEEE--GGGTTSSSS-...--EEE.........E.EE-GGGTTS CS
        RCC1   1 dGrVysWGrndyGqLGlgtt...esvlv.........P.tkveglsgn 35 
                 +G+V++ G+n ++q+ +g++   e+  +         P t v+++s+n
  EFC39711.1 260 NGQVFTRGFNYHNQCANGDDtdiEEYFKlgfqnldynPnTNVNTFSQN 307
                 6****************9996543331122333333566666666655 PP

>> DUF5023  Domain of unknown function (DUF5023)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.3   3.2e-05      0.14     107     149 ..     361     405 ..     339     434 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.2e-05
     DUF5023 107 dhslldklntfstdddegyyyalvddqckvimtywcet..fiddi 149
                   +ll+ + ++s+d++  y ya   d+  v+mt w e+  ++d+ 
  EFC39711.1 361 KNTLLQEVASLSSDEELDYMYACCSDDDLVMMTAWNESnfLLDET 405
                 56899******************************9963234554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (732 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       794  (0.0442858); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.29s 00:00:00.96 Elapsed: 00:00:00.47
# Mc/sec: 4717.53
//
Query:       EFC39712.1  [L=491]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.3e-46  159.2   0.0    1.8e-46  158.8   0.0    1.2  1  Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
    1.6e-12   47.8   0.1      1e-10   42.0   0.0    2.9  3  Pyr_redox    Pyridine nucleotide-disulphide oxidoreductase
      0.006   17.0   0.1      0.014   15.8   0.1    1.5  1  Clp1         Pre-mRNA cleavage complex II protein Clp1
  ------ inclusion threshold ------
      0.046   13.3   0.0       0.17   11.4   0.0    1.8  2  DAO          FAD dependent oxidoreductase
       0.48    9.6   6.1        6.4    5.9   0.2    3.1  3  Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase


Domain annotation for each model (and alignments):
>> Pyr_redox_2  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.8   0.0   4.9e-50   1.8e-46       2     294 .]      89     406 ..      88     406 .. 0.91

  Alignments for each domain:
  == domain 1  score: 158.8 bits;  conditional E-value: 4.9e-50
                  SEEEE--SHHHHHHHHHHHHHTS-EEEEETTHCHHHCSHHHHCHHHHHHHHHHHHH......HHHHCHHHH.CCCCHCCTCEEEEESCEEEEETEEEC CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2   2 dvvviGgGpAGlaaaltlaqagakvtlvelegtclnggcllskallgvaedaeias......evvkklnqg.ielllgeevvkidpgkkkvklekkke 92 
                  ++v++G+G+AG+++ +++   +++v +v   ++++++++ll+  ++g+ e ++i++             ++ ++++ g ++v++d+++++v ++ + e
   EFC39712.1  89 NLVILGSGWAGFRLIKKIDLEKYNVNVV-TPRNHFLFTPLLPGSACGTVELRSIIEpvrravH------HEdYHYYEG-KAVAVDTENQRVICKPNYE 178
                  68**************************.999999999******************6665432......444999999.9********9999987776 PP

                  .TCEEEEEESEEEE---EEE-BCTCTTC.TTBEECCSECHHHHHHCCSS-T..................SEEEEES-SHHHHHHHHHHHHHT-..... CS
                  .xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..................xxxxxxxxxxxxxxxxxxxxxxxx..... RF
  Pyr_redox_2  93 .gdeekiaydklvlAtGssprdlgipGvaenvgklvrtldsaealklkllp..................krivvvGgGyiGvElAaalaklgk..... 166
                   + ++++ ydklv+A G+  +d+gi+Gv+++++ l +++ +a+ ++++ ++                   ++v+vG+G++GvE+Aa+ ++l       
   EFC39712.1 179 nDPNFTLPYDKLVVAVGCDVNDFGIKGVKDYTFPL-KEISHARTIRQQITQcferasnpstpvhlretlLHFVIVGAGATGVEFAAECHDLIRdlsrn 275
                  6899************************7777766.**************************9999999999***************99996668899 PP

                  .........EEEEEESSSSSSTTS-HHHHHHHHHHHHHTTEEEEESCEEEEEEETTEEEEEEETTSCEEEESEEEE-S-EEES-HHCSHCCT-EEEET CS
                  .........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Pyr_redox_2 167 .........evtlveardrllraldkelsaaleealekeGvevklgtsvkeidgngeklevvledgeeidadlvvvavGvrpstelleeklglelder 255
                             t++ea++++l+a+d++l+++ ++ ++++ ++++++++vke+ + ++   ++l+dg+ i++ ++v+++  ++s+ +  ++l +   ++
   EFC39712.1 276 fppeimeevSMTVIEAGSTVLSAFDSSLQKYTQKFFRRNHIKIRTNQQVKEVLSPNS---LKLQDGSIIECGMIVWSA--EISQ-G--RQLPIDP-KT 364
                  999999987899*****************************************9998...9****************9..6663.3..4555554.78 PP

                  TEEE--TTSBES.STTEEE-GGGC..TECCSS--HHHHHHHH CS
                  xxxxxxxxxxxx.xxxxxxxxxxx..xxxxxxxxxxxxxxxx RF
  Pyr_redox_2 256 ggivvdeflrtn.vpgiyaiGDva..ggkggpelaqaAvqqG 294
                   +i vd++l ++  ++i+a+GD+   ++    ++aq+A+qqG
   EFC39712.1 365 KKIIVDDHLHVKgFDNIWALGDISliETVPLAATAQVAQQQG 406
                  99*********99***********99999999********98 PP

>> Pyr_redox  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       3.4   1.2e+04      39      53 ..      60      74 ..      53      84 .. 0.69
   2 ?    2.3   0.0     0.069   2.5e+02       2      37 ..      90     127 ..      89     137 .. 0.85
   3 !   42.0   0.0   2.8e-14     1e-10       1      67 [.     248     328 ..     248     338 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 3.4
                SHHHHHHHHHHHHHT CS
   Pyr_redox 39 Deeaskilqeklekn 53
                ++++sk+++ek+ +n
  EFC39712.1 60 ENTLSKEIREKIMEN 74
                566777777777665 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.069
                 EEEECSSHHHHHHHHHHHHTTSEEEEEESSSSSS..TT CS
   Pyr_redox   2 vvvvGgGyiglElAgalaelgkkVtvversdkll..rl 37 
                 +v++G+G+ g  l + +   + +V vv  ++++l  +l
  EFC39712.1  90 LVILGSGWAGFRLIKKIDLEKYNVNVVTPRNHFLftPL 127
                 89***********9999999999999999999995555 PP

  == domain 3  score: 42.0 bits;  conditional E-value: 2.8e-14
                 EEEEECSSHHHHHHHHHHHHTT..............SEEEEEESSSSSSTTSSHHHHHHHHHHHHHTTEEEECSEEEEEEE CS
   Pyr_redox   1 kvvvvGgGyiglElAgalaelg..............kkVtvversdkllrllDeeaskilqeklekngievllntkveeie 67 
                 + v+vG+G +g+E+A++ ++l                + tv+e+++++l+++D  ++k++q+ +++n+i++++n++v+e+ 
  EFC39712.1 248 HFVIVGAGATGVEFAAECHDLIrdlsrnfppeimeeVSMTVIEAGSTVLSAFDSSLQKYTQKFFRRNHIKIRTNQQVKEVL 328
                 679***************664446667777888866677****************************************96 PP

>> Clp1  Pre-mRNA cleavage complex II protein Clp1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.1   3.8e-06     0.014      35     101 ..      56     121 ..      21     128 .. 0.70

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 3.8e-06
                 -----TS-EEEE-.--GGGTT.EEEEEESSSS....TCCTT--EEEEEEEEEEETTTTEEEEEESSSS CS
        Clp1  35 ekeseetklekveepsselqn.silavsqasakdseeevldssvlGFvyVtevdeekkkltvLsPvpg 101
                 +++ e+t  +++  +++ ++n +++a  +a++k+++  +l s  +GF +++++d ek +++v +P ++
  EFC39712.1  56 SSSVENTLSKEI--REKIMENqKVIASQSANKKKQNLVILGSGWAGFRLIKKIDLEKYNVNVVTPRNH 121
                 222233333333..34677764688888888999999****************************876 PP

>> DAO  FAD dependent oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   4.8e-05      0.17     165     298 ..     158     278 ..     131     297 .. 0.71
   2 ?   -1.8   0.0      0.51   1.8e+03     152     176 ..     306     331 ..     286     381 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 4.8e-05
                 ESECEEEEEEEETCEEEEEEECTEEEE.............EEEEEEE--GGGHHHHHTTCTTTSEEEEEEEEEEEEEECCTHSTGSGCSEEEEE.EEET CS
         DAO 165 egtevtgleeedgkvwgverttpgend.............aadavVnaaGawsdllgllkeldlpispvrgqvlvlkplseklvspaailpvpe.tddd 249
                 eg ++++++ e+   ++v                       +d++V+a G+    +   +++   i++v+ + + lk++s +   +++i +++e  +++
  EFC39712.1 158 EG-KAVAVDTEN---QRV--------IckpnyendpnftlPYDKLVVAVGCD---V---NDF--GIKGVKDYTFPLKEISHARTIRQQITQCFErASNP 236
                 44.444443332...122........112222222445557799********...5...555..78***************8888889999999***** PP

                 TTTEEEEEETTSEEEEEESSEEETTCSSTSCSHHHHHHHHHHHHHHSGG CS
         DAO 250 grgvyvtprkdgrvlvGgtadeesgdddpevdeedidellealrklfPq 298
                 ++ v+++ ++ + v+vG+ a      +     ++++++l++ l++ fP 
  EFC39712.1 237 STPVHLRETLLHFVIVGAGA---T--G--VEFAAECHDLIRDLSRNFPP 278
                 *********99999999976...2..2..23346788888888888865 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.51
                 HHHH.HHHTT-EEEESECEEEEEEEE CS
         DAO 152 lara.aealGveilegtevtgleeed 176
                 + ++ +++++++i+++ +v+++  ++
  EFC39712.1 306 YTQKfFRRNHIKIRTNQQVKEVLSPN 331
                 44443889999999999999974443 PP

>> Pyr_redox_3  Pyridine nucleotide-disulphide oxidoreductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.1      0.22   7.9e+02     231     262 ..      47      78 ..       6     115 .. 0.52
   2 ?    5.9   0.2    0.0018       6.4       1      18 [.     250     267 ..     250     272 .. 0.89
   3 ?    5.6   0.1    0.0022       7.9      82     110 ..     302     330 ..     270     350 .. 0.83

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.22
  Pyr_redox_3 231 fnaevkeikekeeeykvktedgkkvevkddvv 262
                  +n++v + + +++e ++++e  +k+ ++++v+
   EFC39712.1  47 SNQSVSNSTSSSVENTLSKEIREKIMENQKVI 78 
                  22222222222222222222222222222222 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.0018
  Pyr_redox_3   1 iIiGaGPaGlaaaielkk 18 
                  +I+GaG+ G+++a e+ +
   EFC39712.1 250 VIVGAGATGVEFAAECHD 267
                  7*************9976 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0022
  Pyr_redox_3  82 ealeYlrevaksfelpiklfeeVesvkke 110
                   + +Y+++  ++++++i+++++V++v + 
   EFC39712.1 302 SLQKYTQKFFRRNHIKIRTNQQVKEVLSP 330
                  5679********************99765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (491 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1384  (0.0771934); expected 358.6 (0.02)
Passed bias filter:                      717  (0.0399911); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.52
# Mc/sec: 2834.56
//
Query:       EFC39713.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       604  (0.0336884); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.28s 00:00:00.82 Elapsed: 00:00:00.49
# Mc/sec: 1665.02
//
Query:       EFC39714.1  [L=386]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (386 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       849  (0.0473534); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.56u 0.25s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 2603.82
//
Query:       EFC39715.1  [L=1299]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.05   13.9   0.0       0.49   10.7   0.0    2.4  2  TPR_12    Tetratricopeptide repeat
      0.064   13.3   0.0       0.27   11.2   0.0    2.0  2  IalB      Invasion associated locus B (IalB) protein


Domain annotation for each model (and alignments):
>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   5.4e-05      0.49      11      65 ..     885     940 ..     875     944 .. 0.90
   2 ?   -0.2   0.0      0.14   1.2e+03      14      45 ..    1153    1184 ..    1141    1189 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 5.4e-05
      TPR_12  11 avlrrlgrydeAlellekaleiarrl.lGpdhpltattlrnLgrlyralgryeeAl 65 
                 ++++r g   +A + +eka +++     +p+  +ta t+ nL+ ++  +g++e A 
  EFC39715.1 885 LCYQRFGLTKQAHDSFEKAKNLVLFNpSDPNLFNTACTYVNLALYCNSSGDPENAN 940
                 59999******************88877888899******************9885 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.14
      TPR_12   14 rrlgrydeAlellekaleiarrllGpdhplta 45  
                  +   ry e +++++ +l++a++ll+++   ++
  EFC39715.1 1153 FLTSRYPELCANFNPSLDLAESLLEKKGRSLS 1184
                  556799999**************998876655 PP

>> IalB  Invasion associated locus B (IalB) protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0      0.91   8.2e+03      51      77 ..     228     255 ..     222     256 .. 0.80
   2 ?   11.2   0.0     3e-05      0.27      65     107 ..     866     908 ..     861     915 .. 0.94

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.91
        IalB  51 vvlPlgvllpagvslk.vDdkkavelpf 77 
                   lP + ++  g+ ++ +Dd+++++++f
  EFC39715.1 228 CSLPNNYQIGGGLIFSnIDDNEPQQQQF 255
                 578888899888887449****999998 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 3e-05
        IalB  65 lkvDdkkavelpfstClpdgCvaelelddellaalkkgktltl 107
                 l+v+d + ++l+f++ l++ C+ ++ l+++  ++++k+k+l l
  EFC39715.1 866 LSVNDDQRTNLAFMFSLQTLCYQRFGLTKQAHDSFEKAKNLVL 908
                 79999**********************************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1374  (0.0766356); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.91u 0.32s 00:00:01.23 Elapsed: 00:00:00.54
# Mc/sec: 7273.14
//
Query:       EFC39716.1  [L=538]
Description: chromodomain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.7e-13   49.2   0.7    8.3e-13   48.0   0.7    1.6  1  Chromo    Chromo (CHRromatin Organisation MOdifier) domain
    0.00044   19.9   0.1     0.0009   19.0   0.1    1.5  1  QLQ       QLQ


Domain annotation for each model (and alignments):
>> Chromo  Chromo (CHRromatin Organisation MOdifier) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   48.0   0.7   9.3e-17   8.3e-13       1      52 [.     480     528 ..     480     529 .. 0.96

  Alignments for each domain:
  == domain 1  score: 48.0 bits;  conditional E-value: 9.3e-17
                 EEEEEEEEEEEETTEECEEEEEEETTSTGGGTEEEEGGGCSSHSHHHHHHHH CS
      Chromo   1 yeVerIidhrtdkdgleleYlVKWkglpysentWEpeenlekcfqelideFk 52 
                 y+Ve+++ ++++++ + +eYlVKW+g+ +++n+W  e+++ ++   li++F+
  EFC39716.1 480 YTVEKVLRKKIRESSE-PEYLVKWQGYGEEDNSWVKESDMLDK--ALIQNFR 528
                 78**************.***********************988..89**995 PP

>> QLQ  QLQ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.0   0.1     1e-07    0.0009       2      30 ..     114     142 ..     113     143 .. 0.93

  Alignments for each domain:
  == domain 1  score: 19.0 bits;  conditional E-value: 1e-07
         QLQ   2 FtaqQlqeLkaQilAfKyLsknqPvPpeL 30 
                 F ++Q  +L aQilA+ y+ k+q +P ++
  EFC39716.1 114 FLPDQMFQLFAQILAYEYIRKGQTIPNSV 142
                 789***********************775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (538 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2196  (0.122483); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        61  (0.00340231); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.48
# Mc/sec: 3392.60
//
Query:       EFC39717.1  [L=225]
Description: hypothetical protein NAEGRDRAFT_81199 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        1.5    9.1   7.7       0.36   11.1   1.9    2.6  3  CdiA_C    Contact-dependent growth inhibition CdiA C-terminal
        4.6    7.8  14.3      0.065   13.7   1.5    2.9  3  DUF4724   Domain of unknown function (DUF4724)


Domain annotation for each model (and alignments):
>> CdiA_C  Contact-dependent growth inhibition CdiA C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   1.9     4e-05      0.36      24      74 ..      53     104 ..      39     108 .. 0.74
   2 ?    0.4   0.0     0.087   7.8e+02      25      49 ..      87     111 ..      78     117 .. 0.63
   3 ?   -0.2   0.4      0.13   1.2e+03      21      37 ..     194     213 ..     187     222 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 4e-05
      CdiA_C  24 niisnilkkakkQaknivlnlrd.sdlsieeikegieralkwpkkglkelii 74 
                   +sn  k++kkQakn+++n +  s  + +++++ ++   k  kk+ k+ +i
  EFC39717.1  53 GLVSNKKKNVKKQAKNVLINTTSsSFFPSSNVSSTFVFETKHSKKNTKQAMI 104
                 568899999999*********9624445778888777766665577777666 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.087
      CdiA_C  25 iisnilkkakkQaknivlnlrdsdl 49 
                 ++    k +kk +k  ++n+++ +l
  EFC39717.1  87 TFVFETKHSKKNTKQAMINANQLPL 111
                 5555556667777777777776665 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 0.13
      CdiA_C  21 ngk..niisnilkkakk.Qa 37 
                 +++  n+i++i k+ k    
  EFC39717.1 194 ETCfnNTIQKIEKSNKMkKH 213
                 44454788888777655344 PP

>> DUF4724  Domain of unknown function (DUF4724)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   1.8      0.27   2.5e+03      25      36 ..      60      71 ..       7      86 .. 0.58
   2 ?    0.5   2.8     0.097   8.7e+02      26      65 ..      61     105 ..      52     134 .. 0.64
   3 ?   13.7   1.5   7.2e-06     0.065       8      86 ..     138     211 ..     136     218 .. 0.75

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.27
     DUF4724 25 kPlfvqsktnlv 36
                k +  q+k  l+
  EFC39717.1 60 KNVKKQAKNVLI 71
                233334444444 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.097
     DUF4724  26 Plfvqsktnlvtvasss...ts..dhtssldskyvdvvsdqifls 65 
                  +  q+k  l+ ++sss   +s    t  +++k+ ++ + q++++
  EFC39717.1  61 NVKKQAKNVLINTTSSSffpSSnvSSTFVFETKHSKKNTKQAMIN 105
                 555688888888888773322311333446778887777776654 PP

  == domain 3  score: 13.7 bits;  conditional E-value: 7.2e-06
     DUF4724   8 frqfavladtsfnyvkvkPlfvqsktnlvtvassstsdhtssldskyvdvvsdqiflslspkgresekpkeekskekql 86 
                 f+qf +l  t     kv Pl+  s tnl t +sss+   t      + d +s q +++ls +   +++ +  ++ +k  
  EFC39717.1 138 FQQFNMLVST-----KVIPLVDYSPTNLSTLSSSSSLSNTVQSPVTEFDACSVQNSPKLSNETCFNNTIQKIEKSNKMK 211
                 7888888877.....9**************9999988788877888999999999999998866555544333323333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (225 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1133  (0.0631937); expected 358.6 (0.02)
Passed bias filter:                      271  (0.0151152); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1368.53
//
Query:       EFC39718.1  [L=457]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (457 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       835  (0.0465726); expected 358.6 (0.02)
Passed bias filter:                      403  (0.0224776); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2894.15
//
Query:       EFC39719.1  [L=437]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-12   47.5   1.2      2e-07   31.6   0.1    2.9  3  Methyltransf_25  Methyltransferase domain
    5.2e-12   46.3   0.4      3e-09   37.4   0.2    3.1  2  Methyltransf_11  Methyltransferase domain
    8.9e-11   41.9   0.0    3.9e-10   39.8   0.0    1.9  1  Methyltransf_23  Methyltransferase domain
    3.1e-10   40.7   1.2    2.3e-08   34.7   0.3    2.7  2  Methyltransf_12  Methyltransferase domain
    2.6e-09   37.1   1.7    1.6e-07   31.2   1.7    2.5  1  Methyltransf_31  Methyltransferase domain
    0.00028   20.3   0.0      0.018   14.4   0.0    2.4  1  Ubie_methyltran  ubiE/COQ5 methyltransferase family
     0.0031   17.0   0.0      0.052   13.0   0.0    2.5  2  Methyltransf_4   Putative methyltransferase
  ------ inclusion threshold ------
      0.024   14.2   0.1        1.8    8.1   0.0    2.5  2  MTS              Methyltransferase small domain
      0.053   13.2   0.0       0.15   11.7   0.0    1.8  1  TPMT             Thiopurine S-methyltransferase (TPMT)


Domain annotation for each model (and alignments):
>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       7.9   1.6e+04      27      46 ..      76      95 ..      68     123 .. 0.73
   2 !   31.6   0.1     1e-10     2e-07       1      59 [.     174     233 ..     174     257 .. 0.85
   3 !   14.5   0.0   2.3e-05     0.045      53      97 .]     262     303 ..     232     303 .. 0.66

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 7.9
                     EESSHHHHHHHHHHHHHTTT CS
  Methyltransf_25 27 vDiseemleaareraeeegl 46
                     vDis + +++ +++ +++++
       EFC39719.1 76 VDISNGTCQEDKQKQQNQSM 95
                     67777777777766665544 PP

  == domain 2  score: 31.6 bits;  conditional E-value: 1e-10
                      EEEET-TTSHHHHHHHCTSTSSEEEEEESSHHHHHHHHHHHHH...TTT.TEEEEESBCCGBS CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrlgkakvtgvDiseemleaareraee...egl.nvefvqgdaedlp 59 
                      v+d++cG+G+ t++lakr+    v+g Dis++++++a++ + e   e + n+ f ++ ae+l 
       EFC39719.1 174 VVDVACGPGNATFDLAKRC--DFVIGADISQAQIDKAERILGEhrdE-FpNLIFDCACAENLT 233
                      89****************9..9****************888774423.258888888877775 PP

  == domain 3  score: 14.5 bits;  conditional E-value: 2.3e-05
                      SBCCGBSSSTTTEEEEEEESTGGGSSHHHHHHHHHHHHHHEEEEE CS
  Methyltransf_25  53 gdaedlpfedgsfDlvvssgalhhlsdedlekalkeiarvLkpgG 97 
                       + ++ +++ + fDl++++ +lh+++    ek+++++ +vLk+gG
       EFC39719.1 262 NNQQQEEENYEFFDLITVACSLHWFD---FEKFFAQADKVLKKGG 303
                      333334467779******76699986...89*************9 PP

>> Methyltransf_11  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.4   2.8e+03      23      43 ..      75      95 ..      57     116 .. 0.76
   2 !   37.4   0.2   1.5e-12     3e-09       1      95 [.     175     306 ..     175     307 .. 0.79

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.4
                     EEES-HHHHHHHHHHCCHHT- CS
  Methyltransf_11 23 gvDlskemlklakekaseegl 43
                      vD+s+ + +  k+k++++ +
       EFC39719.1 75 HVDISNGTCQEDKQKQQNQSM 95
                     689999999999988888875 PP

  == domain 2  score: 37.4 bits;  conditional E-value: 1.5e-12
                      EEET-TTSHHHHHHHHTTSEEEEEES-HHHHHHHHHHCCHHT-...EEEE....................................TTEECCCT CS
  Methyltransf_11   1 LdvGcGtGrlaealakrgarvvgvDlskemlklakekaseegl...kvef....................................vvadaekl 55 
                      +dv+cG G  + +lakr+  v+g D+s+++++ a++   e +    +  +                                      ++ ++ 
       EFC39719.1 175 VDVACGPGNATFDLAKRCDFVIGADISQAQIDKAERILGEHRDefpN--LifdcacaenltdlvekhrstlkkyqhevshstcddeNNSNNQQQ 266
                      59*****************************9996655555534452..033557788888889999999999999999988876522222222 PP

                      .SS-TT-EEEEEEES-CCC-CCHHHHHHHHHHHEEEEEEEE CS
  Methyltransf_11  56 .pfednsfDlvvssevlhhvedpekalkeiaRvLkpgGllv 95 
                         + + fDl+++  +lh++ d ek+++++ +vLk+gG+l+
       EFC39719.1 267 eEENYEFFDLITVACSLHWF-DFEKFFAQADKVLKKGGYLI 306
                      1223369*************.7*****************98 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.8   0.0   1.9e-13   3.9e-10       2     140 ..     147     330 ..     146     346 .. 0.73

  Alignments for each domain:
  == domain 1  score: 39.8 bits;  conditional E-value: 1.9e-13
  Methyltransf_23   2 daqreeelsdklerll.pk..lraggrvLdiGcGtG.illevlrengfs.vtgvDlspeaveiae............................. 61 
                      +++r++++ ++ +++  pk   +a++ v+d++cG G  + +++  ++++ v+g D+s +++++ae                             
       EFC39719.1 147 ERYRPRYPPALFDKMImPKleGFASKVVVDVACGPGnATFDLA--KRCDfVIGADISQAQIDKAErilgehrdefpnlifdcacaenltdlvek 238
                      5666666555555544355446999***********4456655..3455267****************************************** PP

  Methyltransf_23  62 ...kakkaqkdqfdeqeaaepqg........kfdlIvlrevlehvp..dppellrqiatllkpgGylllseplaslkedrllldwlylvpag 140
                         + kk+q++  ++ +++e++          +++  l+ v ++++  d+++ ++q+ + lk gGyl+  ++  +  ++++++++  ++ ++
       EFC39719.1 239 hrsTLKKYQHEVSHSTCDDENNSnnqqqeeeNYEFFDLITVACSLHwfDFEKFFAQADKVLKKGGYLIAWTYFLNTFSNEKAEQIITDFYNS 330
                      99966666666666666666444555566665555555566666666677******************999988889999988874444444 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       7.3   1.4e+04      26      39 ..      76      89 ..      60     101 .. 0.63
   2 !   34.7   0.3   1.1e-11   2.3e-08       1      99 []     175     305 ..     175     305 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 7.3
  Methyltransf_12 26 vDispsaiedakek 39
                     vDis   ++  k+k
       EFC39719.1 76 VDISNGTCQEDKQK 89
                     56666666222222 PP

  == domain 2  score: 34.7 bits;  conditional E-value: 1.1e-11
  Methyltransf_12   1 LeiGcGtGsllralleklpdieytgvDispsaiedakeklakrennnnnnvelealdlldldgg.............................. 64 
                      +++ cG G+ ++ l+++     ++g Dis+++i d++e++  ++++ + n+ ++   +++l +                               
       EFC39719.1 175 VDVACGPGNATFDLAKR--CDFVIGADISQAQI-DKAERILGEHRDEFPNLIFDCACAENLTDLvekhrstlkkyqhevshstcddennsnnqq 265
                      599***********999..55555*********.999999999999*****9998877776666778*************************** PP

  Methyltransf_12  65 ......ssfDlvvasnvlhhlkdirevldnirklLkpgGrl 99 
                            + fDl+++++ lh++ d +++++++ k+Lk+gG+l
       EFC39719.1 266 qeeenyEFFDLITVACSLHWF-DFEKFFAQADKVLKKGGYL 305
                      ********************6.*****************87 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.2   1.7     8e-11   1.6e-07       5     110 ..     172     308 ..     170     351 .. 0.80

  Alignments for each domain:
  == domain 1  score: 31.2 bits;  conditional E-value: 8e-11
  Methyltransf_31   5 lrvlDlGCGtGeltfelaeelgpkae.vvGiDiseeaielArenaqklgld..nveFeqgdieeleklled....................... 72 
                      ++v+D++CG G+ tf la++     + v+G Dis+  i +A+ ++ ++  +  n+ F  + +e+l  l+e+                       
       EFC39719.1 172 KVVVDVACGPGNATFDLAKRC----DfVIGADISQAQIDKAERILGEHRDEfpNLIFDCACAENLTDLVEKhrstlkkyqhevshstcddenns 261
                      679***************653....33****************8776654444**999988888776655557888888888888888888888 PP

  Methyltransf_31  73 ..........ekfDlilsnevlnaladpdkileeiervlkpggillie 110
                                e fDli+  + l +  d +k++ ++ +vlk+gg+l++ 
       EFC39719.1 262 nnqqqeeenyEFFDLITVACSL-HWFDFEKFFAQADKVLKKGGYLIAW 308
                      8888888888888888888888.999999****************965 PP

>> Ubie_methyltran  ubiE/COQ5 methyltransferase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.0     9e-06     0.018      47     150 ..     170     306 ..     156     320 .. 0.68

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 9e-06
                      -TTEEEEES-TT-HHHHHHHHHHHHHH................................EEEEEES-HHHHHHHHHHHHHHTSS..TEEEEE-- CS
  Ubie_methyltran  47 rgakvlDvagGtgDlafklsdsvgekg................................kvvvlDinenmLkvgekklkeegki..nieflqan 106
                       ++ v+Dva+G g+ +f+l++  +                                     ++ D+ e+  ++ +k  +e + +  + e  ++n
       EFC39719.1 170 ASKVVVDVACGPGNATFDLAKRCDFVIgadisqaqidkaerilgehrdefpnlifdcacAENLTDLVEKHRSTLKKYQHEVSHStcDDEN-NSN 262
                      456799**************9987665677889999999999999999999877766663334444443333333333333333112233.344 PP

                      TTT-TTS-.T-EEEEEEES-GGG-S-HHHHHHHHHHHEEEEEEEE CS
  Ubie_methyltran 107 aeeLpfed.dsfDvvtvsfGlrnvtDklkaLkeayrvlkpGGrlv 150
                       ++ ++e+ + fD++tv+  l  + D +k + +a +vlk GG l+
       EFC39719.1 263 NQQQEEENyEFFDLITVACSLHWF-DFEKFFAQADKVLKKGGYLI 306
                      444444445889999999999866.89999999999999999876 PP

>> Methyltransf_4  Putative methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.0   0.0   2.6e-05     0.052       3      71 ..     172     239 ..     170     245 .. 0.87
   2 ?    0.9   0.0      0.14   2.7e+02      98     121 ..     290     313 ..     288     342 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.6e-05
                     EEEEEET-TTSHHHHHHHHHSTTSEEEEEES-HHHHHHHHHHHHHC..TTSSEEEEES-CCCHHHHCS-TT CS
  Methyltransf_4   3 pvvleiGcGkGeflvalAkknPdknflGiEirvkvvakvlkkieal..elkNlrilrgdalkvllelledg 71 
                     +vv+++ cG G+++ +lAk+     ++G +i++  ++k+ +  +++  e+ Nl   +  a + l++l+e++
      EFC39719.1 172 KVVVDVACGPGNATFDLAKRC--DFVIGADISQAQIDKAERILGEHrdEFPNLIFDCACA-ENLTDLVEKH 239
                     799***************985..789***************9999888999998888877.7888887775 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.14
                     HHHHHHHHHEEEEEEEEEEESHHH CS
  Methyltransf_4  98 ellkelarvLkkgGvlelaTDvee 121
                     ++ +++ +vLkkgG+l + T + +
      EFC39719.1 290 KFFAQADKVLKKGGYLIAWTYFLN 313
                     6888999*********99887443 PP

>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.0   0.00092       1.8      23      78 ..     162     215 ..     159     236 .. 0.80
   2 ?    3.4   0.0     0.024        48     119     136 ..     289     306 ..     236     330 .. 0.92

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00092
                 HHHHCHCCTCSEEEEET-TTSHHHHHHHHHTTC.EEEEEESBHHHHHHHHHHHHHT CS
         MTS  23 LletlpkelsgkvlDlGcGaGvlgaalakespeaevtlvdvdarAlesakenlean 78 
                 ++ +l+  +s+ v+D++cG G  +  lak+++   v   d++ + ++ a++ l ++
  EFC39719.1 162 IMPKLEGFASKVVVDVACGPGNATFDLAKRCDF--VIGADISQAQIDKAERILGEH 215
                 566777778899*****************9988..788888888888888766655 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.024
                 HHHHHHHHHHEEEEEEEE CS
         MTS 119 eeliaeAkeaLkegGeLl 136
                 e+++a+A ++Lk+gG L+
  EFC39719.1 289 EKFFAQADKVLKKGGYLI 306
                 789************986 PP

>> TPMT  Thiopurine S-methyltransferase (TPMT)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   7.7e-05      0.15      45      88 ..     178     219 ..     155     232 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 7.7e-05
                 T-TT-HHHHHH-BTTEEEEEE-S-HHHHHHHHHHHTTSGGGGGE CS
        TPMT  45 lCGkaldlvwlAeqgrevvGvelselAvekffeeanlepkvkel 88 
                  CG +     lA++ ++v+G ++s++ + k  +e+ l ++ +e+
  EFC39719.1 178 ACGPGNATFDLAKRCDFVIGADISQAQIDK--AERILGEHRDEF 219
                 6*****************************..688888887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (437 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       996  (0.0555525); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2490.64
//
Query:       EFC39720.1  [L=1319]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    4.7e-57  193.7  33.6    4.3e-31  108.6  21.8    2.2  2  ABC_membrane  ABC transporter transmembrane region
    5.6e-49  166.2   0.2    1.3e-29  103.4   0.0    2.7  2  ABC_tran      ABC transporter
    6.1e-07   29.1  11.4     0.0005   19.6   0.2    3.8  4  SMC_N         RecF/RecN/SMC N terminal domain
    4.6e-06   26.6   0.0       0.03   14.3   0.1    2.5  2  RsgA_GTPase   RsgA GTPase
    7.9e-06   25.9   1.0       0.15   12.2   0.1    2.7  2  MMR_HSR1      50S ribosome-binding GTPase
    1.5e-05   24.6   1.8       0.16   11.7   0.1    2.6  2  AAA_29        P-loop containing region of AAA domain
     0.0011   19.4   0.1       0.31   11.4   0.0    2.9  2  AAA_16        AAA ATPase domain
     0.0014   18.5   6.5      0.082   12.7   0.5    3.4  3  AAA_21        AAA domain, putative AbiEii toxin, Type IV TA s
     0.0029   17.4   0.3       0.46   10.2   0.0    2.5  2  AAA_24        AAA domain
     0.0066   16.7   0.4        4.7    7.5   0.0    3.2  3  AAA_22        AAA domain
     0.0083   16.7   9.1       0.15   12.5   0.3    3.2  3  AAA_23        AAA domain
     0.0094   16.3   0.3         32    5.0   0.0    3.8  3  RNA_helicase  RNA helicase
  ------ inclusion threshold ------
      0.011   15.9   1.2        6.5    7.0   0.0    3.0  3  Roc           Ras of Complex, Roc, domain of DAPkinase
      0.019   15.0   1.8          1    9.4   0.0    2.8  2  Dynamin_N     Dynamin family
      0.025   14.1   0.1        3.5    7.1   0.0    2.3  2  AAA_7         P-loop containing dynein motor region
       0.08   11.6   0.1       0.14   10.7   0.1    1.3  1  RdRP          RNA dependent RNA polymerase
       0.11   12.3   0.1         19    5.0   0.0    2.4  2  DEAD          DEAD/DEAH box helicase
       0.12   12.3   0.3         25    4.9   0.0    3.5  3  AAA_5         AAA domain (dynein-related subfamily)
       0.13   12.2   0.1         19    5.1   0.0    2.6  2  NACHT         NACHT domain
       0.13   11.8   0.0         16    5.0   0.0    2.3  2  AAA_25        AAA domain
       0.13   11.9   0.0        4.2    7.0   0.0    2.6  2  AAA_30        AAA domain
          2    8.4   9.5        4.7    7.2   0.1    3.7  4  DUF87         Helicase HerA, central domain


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   91.0   3.9   1.2e-28     1e-25      78     274 .]     206     399 ..     196     399 .. 0.95
   2 !  108.6  21.8   5.2e-34   4.3e-31       5     269 ..     750    1013 ..     747    1018 .. 0.92

  Alignments for each domain:
  == domain 1  score: 91.0 bits;  conditional E-value: 1.2e-28
                   HHHHHHHHCSTHHHHHHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane  78 rklfkkilrqpmsffdtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqk 174
                   +++f+k+ r   s  ++  +Gel++++++d+++l  ++ e + l++++++++vg  ++++++g + +++++  ++ +++v  v+ak+l+k++ + +k
    EFC39720.1 206 ASIFQKLTRITPSARSKFESGELTNLFSTDTNRLAGVIIELHDLWLTPIMIIVGMTLIILFFGFS-AVAGILAMIAFAPVLGVLAKLLTKIETELSK 301
                   689*************************************************************8.8****************************** PP

                   HHHHHHHHHHHHHHTHHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHH CS
  ABC_membrane 175 avakassvaeEslsgirtVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailf 271
                   + +++ +v+ E+l+gir Vk f  e+++ e+  +a+ ++++  +k a++ + ++  t + ++++ + +++++++++  gel+++++++ l+lf ++ 
    EFC39720.1 302 HKDERIKVMSEILNGIRIVKFFVFEDKMKERVYDARAKEYQGLRKGALI-RCFQLLTSATTSVVGSGVTFISHYYM-GGELTMSNMFTGLVLFETFR 396
                   *****************************************97777776.56778899999999999999999999.88*****************9 PP

                   HHH CS
  ABC_membrane 272 gal 274
                   ++l
    EFC39720.1 397 TPL 399
                   986 PP

  == domain 2  score: 108.6 bits;  conditional E-value: 5.2e-34
                    HHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHSCHHH CS
  ABC_membrane    5 illailagvlsplfplvlgrildtlldkgdpetealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtnsvGe 99  
                    ill i+  ++s+ + l+ + +++++++ ++ +   ++ y +++l++g +++++ +++s ++++ + + s +l++k+++ +lr+p+ ffd+n+vG+
    EFC39720.1  750 ILLCIFLSFASLGTKLLSQMWISFMNM-NTFQM-SIANYVWIYLVIGCLDSLILFIRSGFYSYGSLKSSLKLHNKMLEGVLRAPILFFDQNPVGR 842 
                    667777788889999999999999999.55555.5************************************************************ PP

                    HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHH CS
  ABC_membrane  100 llsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgirtVk 194 
                    +l+r+t d++  ++ + +++ + +  +l+++ ++i++ ++ + + +v+++i ++++l+++++   ++++++ e+ a++++ s++   l+gi t+k
    EFC39720.1  843 ILNRFTQDINATDNEMLFTIPVAINIILNILLTIILISTITPLFLVVIVPIGLVFYLIQIYYRVSSREIRRLESIARSPSLSHFSSCLQGINTIK 937 
                    *********************************************************************************************** PP

                    HTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT.TSSTHHHHHHHHHHHHH CS
  ABC_membrane  195 afgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvis.gelsvgdlvvflslfai 269 
                    a+  +e+  +  + +++ a k +  +  +n++l++++q+l+ ++++++++f++   ++   + ++ l   ++++ +
    EFC39720.1  938 ALLVHEQIFHDCNRKIDFATKHSHFRFAINRWLGIRIQVLAQIVVFFTALFAIIARHTtTYIAPSLLALSITYSLQ 1013
                    *************************************************999887766334444555555555555 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.1   0.0   3.9e-19   3.2e-16       1     134 [.     480     616 ..     480     619 .. 0.75
   2 !  103.4   0.0   1.6e-32   1.3e-29       1     137 []    1085    1233 ..    1085    1233 .. 0.96

  Alignments for each domain:
  == domain 1  score: 60.1 bits;  conditional E-value: 3.9e-19
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH............HHHTCHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx............xxxxxxxx RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren............esdeeiek 87 
                 lkn++l+l++g+++ ++G++G+GKS+L++ ++g +   +G++ ++             +++    ++p + +++ vren            +     ek
  EFC39720.1 480 LKNINLTLEKGKLYCLIGNTGSGKSSLFSSIYGDTVIVNGSVSVN-----------PYSKLTLSDENPWMINGT-VRENiifdksldfdseK----YEK 562
                 79****************************************665...........455555666666666666.66666666666533322....333 PP

                 HHHHSTTGG.......TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEES CS
                 xxxxxxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  88 alsklglke.......lkdtvvksspssLSgGqkqrvalarallkkpkllllDE 134
                 +l+  +l          +++ +++s+ +LS Gqk r+ lara  ++++++l+D 
  EFC39720.1 563 VLDVCQLRSdlagfqnYDQSEIGYSGINLSLGQKHRIGLARACYSNSDIILMDS 616
                 333333333333333367899999*****************************6 PP

  == domain 2  score: 103.4 bits;  conditional E-value: 1.6e-32
                  EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH......HHHTCHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxx RF
    ABC_tran    1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren......esdeeiekalsk 91  
                  lk +++++ +g+kv+ivG++G+GKS+Ll  l + l+ ++G+i++dg +++++ l++lr+++ ++pq+p lf ++ +r n        d+ei  al++
  EFC39720.1 1085 LKSINFTIDPGTKVGIVGRSGSGKSSLLISLFRFLEADSGNIKIDGYNISDIGLKRLRQSLLIIPQQPVLFTGT-IRYNldifneFTDKEIWSALER 1180
                  789***********************************************************************.99999***97777889999999 PP

                  STTGG.......TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                  xxxxx.......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   92 lglke.......lkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137 
                  + lk+       + d++v++++ ++S G++q v+lar++l+k+k++++DE ta
  EFC39720.1 1181 VHLKNkirsmekKLDEPVTENGGNFSIGERQLVSLARCILRKAKIIIFDESTA 1233
                  9999999999999999**9*******************************996 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.0   0.3    0.0043       3.5      25      44 ..     491     510 ..     480     514 .. 0.84
   2 ?   -2.3   0.0         3   2.4e+03     153     211 ..     603     662 ..     555     666 .. 0.71
   3 !    7.7   0.4    0.0026       2.1      27      50 ..    1098    1120 ..    1085    1136 .. 0.73
   4 !   19.6   0.2   6.2e-07    0.0005     117     212 ..    1168    1276 ..    1153    1280 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0043
                 SEEEEEESTTSSHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnlldAi 44 
                 ++ +++G+ GSGKs+l+ +i
  EFC39720.1 491 KLYCLIGNTGSGKSSLFSSI 510
                 46789************999 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 3
                 HHCCS--SEEEECTTTTTS-HHHHHHH.HHHHHHHCTTSEEEEE-SSHHHCCC-SCEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 153 iqkvkpaplyllDeidaaLDeknvkkv.aellkeksknaQfivislreemlekadklvgv 211
                    ++ + + l+D     +D++  kk+  + +    k+   i i+++ ++l+ ad+++ +
  EFC39720.1 603 RACYSNSDIILMDSSLNSIDARLCKKIfRDCIMDYLKDRTRILITHSLQLLKMADEVIVL 662
                 445666667777766666666555444134555666666689999999999999998765 PP

  == domain 3  score: 7.7 bits;  conditional E-value: 0.0026
                  EEEEESTTSSHHHHHHHHHHHCTT CS
                  xxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N   27 taivGpNGSGKsnlldAilFvLGe 50  
                    ivG+ GSGKs+ll ++ F + e
  EFC39720.1 1098 VGIVGRSGSGKSSLLISL-FRFLE 1120
                  359************999.65544 PP

  == domain 4  score: 19.6 bits;  conditional E-value: 6.2e-07
                  EE-HHHHHHHHHCTT-STT.................CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE- CS
                  xxxxxxxxxxxxxxxxxxx.................xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N  117 evtkkevsellesagiske.................lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivis 196 
                  e t ke+ + le+++++ +                 ++S Ge++Lv+la        ++a + ++De  a  D++  + v ++++e+ k+a +i ++
  EFC39720.1 1168 EFTDKEIWSALERVHLKNKirsmekkldepvtenggNFSIGERQLVSLARC----ILRKAKIIIFDESTAFVDHQADALVQKIVREEFKHATIITVA 1260
                  5677888888888888888888888888999999999**********9876....578899************************************ PP

                  SSHHHCCC-SCEEEEE CS
                  xxxxxxxxxxxxxxxx RF
       SMC_N  197 lreemlekadklvgvt 212 
                  +r +++ ++dk++ + 
  EFC39720.1 1261 HRLDTIIDSDKIIVME 1276
                  *******999998765 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.1   3.6e-05      0.03      86     131 ..     476     522 ..     437     526 .. 0.80
   2 !    9.7   0.0   0.00092      0.75      88     126 ..    1083    1122 ..    1005    1130 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 3.6e-05
                  THTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT-----S--- CS
  RsgA_GTPase  86 tkegleelkellkd.ktsvlvGqSGvGKStLinallpelelktgevs 131
                  ++  l++++  l++ k+ +l+G++G GKS+L  ++ +++ +  g+vs
   EFC39720.1 476 SSPILKNINLTLEKgKLYCLIGNTGSGKSSLFSSIYGDTVIVNGSVS 522
                  455677888888888********************999887777776 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00092
                   TTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT---- CS
  RsgA_GTPase   88 egleelkellkd.ktsvlvGqSGvGKStLinallpelelk 126 
                     l++++  ++    + +vG SG GKS+L+ +l   le+ 
   EFC39720.1 1083 PVLKSINFTIDPgTKVGIVGRSGSGKSSLLISLFRFLEAD 1122
                   456777888887344559***********98887665555 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.5   0.1    0.0003      0.25       3      27 ..     494     518 ..     493     540 .. 0.88
   2 !   12.2   0.1   0.00018      0.15       1      24 [.    1097    1121 ..    1097    1135 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.0003
                 EEEESTTSSHHHHHHHHHTSTEEES CS
    MMR_HSR1   3 aivGrpNvGKStLinaltgekaivs 27 
                 +++G++ +GKS+L++++ g+++iv+
  EFC39720.1 494 CLIGNTGSGKSSLFSSIYGDTVIVN 518
                 69****************9987774 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00018
                  EEEEEESTTSSHHHHHHHHHTS.TE CS
    MMR_HSR1    1 evaivGrpNvGKStLinaltge.ka 24  
                  +v+ivGr+ +GKS+L+ +l++  +a
  EFC39720.1 1097 KVGIVGRSGSGKSSLLISLFRFlEA 1121
                  69**************999875444 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.1    0.0002      0.16      20      41 ..     488     509 ..     469     526 .. 0.79
   2 !   11.6   0.2   0.00022      0.18      18      39 ..    1091    1112 ..    1085    1123 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.0002
      AAA_29  20 dlkg.atlltGpsGsGKSTllDA 41 
                 + kg  + l+G++GsGKS+l+ +
  EFC39720.1 488 E-KGkLYCLIGNTGSGKSSLFSS 509
                 3.446899***********9855 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00022
      AAA_29   18 eidlkgatlltGpsGsGKSTll 39  
                  +id+   + ++G+sGsGKS+ll
  EFC39720.1 1091 TIDPGTKVGIVGRSGSGKSSLL 1112
                  666666788***********98 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.047        39      25      44 ..     491     510 ..     480     531 .. 0.82
   2 !   11.4   0.0   0.00038      0.31      28      52 ..    1099    1143 ..    1085    1250 .. 0.68

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.047
      AAA_16  25 elvllsGesGvGKsslvrel 44 
                  l  l+G+ G+GKssl  ++
  EFC39720.1 491 KLYCLIGNTGSGKSSLFSSI 510
                 56679**********98766 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00038
      AAA_16   28 llsGesGvGKsslvrellralekd....................g 52  
                   ++G sG+GKssl+ +l+r le+d                     
  EFC39720.1 1099 GIVGRSGSGKSSLLISLFRFLEADsgnikidgynisdiglkrlrQ 1143
                  589***************999999666655555555555555541 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1       7.3     6e+03      28      80 ..     140     192 ..     126     213 .. 0.76
   2 !    7.6   0.1    0.0035       2.8       2      21 ..     493     512 ..     492     562 .. 0.84
   3 !   12.7   0.5    0.0001     0.082       3     130 ..    1099    1218 ..    1098    1309 .. 0.76

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 7.3
      AAA_21  28 dvegltdelsggggirkipslldlydpeipfefeieeflsqgvryryglrler 80 
                   + ++ e   +++i+k p+ + ++++ + fe ++ ++ +++ ry  ++   +
  EFC39720.1 140 QEIEDNFEGLQHSDIPKLPKHIQTDNIYPIFEKSFKHVYLKKRRYYSEAGNLW 192
                 55667777788888888888888888888888888888888888877665555 PP

  == domain 2  score: 7.6 bits;  conditional E-value: 0.0035
      AAA_21   2 nvliGpNgsGKSnLLdaldl 21 
                  +liG  gsGKS+L+  +++
  EFC39720.1 493 YCLIGNTGSGKSSLFSSIYG 512
                 68*************99964 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 0.0001
      AAA_21    3 vliGpNgsGKSnLLdaldllarldrdvegltdelsggggirkipslldlydpeipfefeieeflsqgvryryglrlersqv.....eeklssvetll 94  
                  +++G+ gsGKS+LL  l  +             + ++g+i+++ + +  +  +   +  ++  ++q v +++ +r + +++     +e +s++e+++
  EFC39720.1 1099 GIVGRSGSGKSSLLISLFRF------------LEADSGNIKIDGYNISDIGLKRLRQSLLI-IPQQPVLFTGTIRYNLDIFneftdKEIWSALERVH 1182
                  69**********99777555............46677777777777777777777777777.88999988888888888888888************ PP

      AAA_21   95 esgllldkrsleeedvfnpeargirggvsvfslkel 130 
                  ++  ++  + + +e+v+ + +  + g ++  sl+  
  EFC39720.1 1183 LKNKIRSMEKKLDEPVTENGGNFSIGERQLVSLARC 1218
                  **9999999999999988766666665555555555 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.029        24       5      30 ..     493     518 ..     489     530 .. 0.85
   2 !   10.2   0.0   0.00056      0.46       3      80 ..    1096    1237 ..    1095    1253 .. 0.71

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.029
      AAA_24   5 iliyGpsgiGKTtlakelgpkplfid 30 
                 ++++G  g+GK++l +++  ++++++
  EFC39720.1 493 YCLIGNTGSGKSSLFSSIYGDTVIVN 518
                 79*************99977777765 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00056
      AAA_24    3 lkiliyGpsgiGKTtlakelgpkplfidtekGlksldadkfpdie........................swedfldevvel................ 59  
                   k+ i+G sg+GK++l+ +l   + f+  + G  ++d+ ++ di                         +    ld ++e+                
  EFC39720.1 1096 TKVGIVGRSGSGKSSLLISL---FRFLEADSGNIKIDGYNISDIGlkrlrqslliipqqpvlftgtiryN----LDIFNEFtdkeiwsalervhlkn 1185
                  6899****************...99999999999999999999966666666666666666666633332....33333334444666777777777 PP

      AAA_24   60 ...............................aaeladyktlviDtideleel 80  
                                                 ++ l++ k++++D  + ++++
  EFC39720.1 1186 kirsmekkldepvtenggnfsigerqlvslaRCILRKAKIIIFDESTAFVDH 1237
                  7777777777777777777777777777777777777777777777777765 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.2     0.024        20       4      22 ..     489     507 ..     486     515 .. 0.86
   2 ?   -2.9   0.0       9.3   7.6e+03      43      70 ..    1022    1051 ..    1008    1059 .. 0.77
   3 !    7.5   0.0    0.0058       4.7      10      47 ..    1100    1130 ..    1096    1245 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.024
      AAA_22   4 tagilvvtGesGtGKTtll 22 
                 + ++ +++G +G+GK+ l 
  EFC39720.1 489 KGKLYCLIGNTGSGKSSLF 507
                 567899**********885 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 9.3
      AAA_22   43 v..fvtlpsstsskdllrellralglelka 70  
                  +  fv+l ss++s +   + ++++++e+ +
  EFC39720.1 1022 IryFVDLESSMTSVERIVHYCNNIDSEAPT 1051
                  155899999999999999999999988777 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.0058
      AAA_22   10 vtGesGtGKTtllrrlleqldeeakaeeerpevvfvtl 47  
                  ++G sG+GK+ ll  l++ l++       +++ ++++ 
  EFC39720.1 1100 IVGRSGSGKSSLLISLFRFLEA-------DSGNIKIDG 1130
                  89****************9975.......555555554 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.3   0.00019      0.15      12      39 ..     482     510 ..     474     512 .. 0.80
   2 ?   -2.5   0.3       7.5   6.1e+03      76     110 ..     684     722 ..     651     735 .. 0.59
   3 !    8.9   0.3    0.0024         2      13      65 ..    1090    1138 ..    1085    1315 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00019
      AAA_23  12 dqeidF.skgltlItGpNGaGKTTildAi 39 
                 + ++ + + +l++++G++G+GK++++  i
  EFC39720.1 482 NINLTLeKGKLYCLIGNTGSGKSSLFSSI 510
                 4444554558***************9766 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 7.5
      AAA_23  76 eltfenkdgry....trsiererelskkkgkttkkakle 110
                 +l  e++++++      +i++e+++sk+ +k    + + 
  EFC39720.1 684 KLITEDDNNEKseesSPEISEEKPKSKTTEKGSESKGKL 722
                 444455555444444455555555555544444444444 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0024
      AAA_23   13 qeidFskgltlItGpNGaGKTTildAiklaLygetprlsrksgrgfeksdvei 65  
                  ++id + ++  I+G  G+GK+++l  +   L  ++   ++ +  g++ sd+ +
  EFC39720.1 1090 FTIDPGTKV-GIVGRSGSGKSSLLISLFRFLEADS---GNIKIDGYNISDIGL 1138
                  455555444.9************977766665543...333334556666554 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0       0.2   1.6e+02       2      19 ..     494     511 ..     493     564 .. 0.86
   2 ?    5.0   0.0     0.039        32      28      71 ..     661     704 ..     646     714 .. 0.78
   3 ?    4.0   0.0      0.08        66       3      27 ..    1100    1124 ..    1098    1135 .. 0.81

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.2
  RNA_helicase   2 wlyGpsgeGKStlakeLa 19 
                   +l G++g GKS+l  ++ 
    EFC39720.1 494 CLIGNTGSGKSSLFSSIY 511
                   789*********998865 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.039
  RNA_helicase  28 lkkkdsvysrnpeddfwdgYtgqevvvidDfgqvkdeenpsdla 71 
                     +++++++++p +d++d+Y+  + +  dD +++++e++p++ +
    EFC39720.1 661 VLQQGEIVAKGPLKDIMDSYDFSKLITEDDNNEKSEESSPEISE 704
                   56779999**********************98888775665544 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.08
  RNA_helicase    3 lyGpsgeGKStlakeLakallkklk 27  
                    ++G+sg GKS+l  +L + l+ +++
    EFC39720.1 1100 IVGRSGSGKSSLLISLFRFLEADSG 1124
                    79**********9999988876664 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0    0.0079       6.5       3      24 ..     494     515 ..     492     532 .. 0.88
   2 ?    6.1   0.1     0.015        12       1      20 [.    1097    1116 ..    1097    1141 .. 0.83
   3 ?   -1.5   0.0       3.3   2.7e+03      69     119 ..    1212    1264 ..    1207    1265 .. 0.58

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0079
                 EEESSTTSSHHHHHHCHCT-CC CS
         Roc   3 vlvGdsgvGKtsllkrfvedkf 24 
                 +l+G++g+GK+sl++++  d++
  EFC39720.1 494 CLIGNTGSGKSSLFSSIYGDTV 515
                 79************99988775 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.015
                  EEEEESSTTSSHHHHHHCHC CS
         Roc    1 KvvlvGdsgvGKtsllkrfv 20  
                  Kv +vG sg+GK+sll ++ 
  EFC39720.1 1097 KVGIVGRSGSGKSSLLISLF 1116
                  899************97665 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 3.3
                  TTTT-HHHHCTSCEEEEEEEGH.HHHCHHHHHHHH.HHHCSSS-EEEEEE-TT CS
         Roc   69 frslhplylreaalailvydsr.ssenlkeWlkel.kkvagkspvilvgnkiD 119 
                    sl+++ lr+a+++i+   +   +++++  ++++ +++ +++ +i v+ ++D
  EFC39720.1 1212 LVSLARCILRKAKIIIFDESTAfVDHQADALVQKIvREEFKHATIITVAHRLD 1264
                  55666667777766654433331235666777766245567778888888877 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.0    0.0013         1       3      31 ..     495     523 ..     494     582 .. 0.88
   2 ?    3.6   0.6     0.073        60       1      18 [.    1098    1115 ..    1098    1120 .. 0.87

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0013
                 EEEBTTTTHHHHHHHHHTS--S---SSS- CS
   Dynamin_N   3 vvGsqSsGKSSvlnaLlgedilprgpnpt 31 
                 ++G++ sGKSS+  ++ g+ + ++g+  +
  EFC39720.1 495 LIGNTGSGKSSLFSSIYGDTVIVNGSVSV 523
                 79*******************99988655 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.073
                  EEEEEBTTTTHHHHHHHH CS
   Dynamin_N    1 iavvGsqSsGKSSvlnaL 18  
                  + +vG   sGKSS+l +L
  EFC39720.1 1098 VGIVGRSGSGKSSLLISL 1115
                  679***********9776 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0    0.0043       3.5      26      53 ..     483     510 ..     477     527 .. 0.88
   2 ?    4.3   0.0      0.03        25      30      60 ..    1092    1122 ..    1086    1133 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0043
       AAA_7  26 lelllknkkpvllvGptGtGKtviikdl 53 
                 ++l l+++k  +l+G+tG+GK+++ +++
  EFC39720.1 483 INLTLEKGKLYCLIGNTGSGKSSLFSSI 510
                 578899999**************99874 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.03
       AAA_7   30 lknkkpvllvGptGtGKtviikdllkkldke 60  
                  ++ + +v +vG +G+GK++++ +l++ l+ +
  EFC39720.1 1092 IDPGTKVGIVGRSGSGKSSLLISLFRFLEAD 1122
                  666788999***********99998887754 PP

>> RdRP  RNA dependent RNA polymerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.1   0.00018      0.14     327     369 ..     626     669 ..     605     689 .. 0.79

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00018
        RdRP 327 lkalv.keslrklkekarIpvpksatllgvaDetgvLkegevfv 369
                 +k+++ +  ++ lk++ rI +  s  ll  aDe  vL++ge+  
  EFC39720.1 626 CKKIFrDCIMDYLKDRTRILITHSLQLLKMADEVIVLQQGEIVA 669
                 344330345677999***************************84 PP

>> DEAD  DEAD/DEAH box helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0     0.023        19       8      34 ..     483     510 ..     479     534 .. 0.81
   2 ?    4.5   0.0     0.031        26      13     147 ..    1094    1248 ..    1084    1259 .. 0.71

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.023
                 HHHHH.TTCEEEEEESTTSSHHHHHHHH CS
                 xxxxx.xxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   8 iplil.gggdvlvaaeTGsGKTlaflip 34 
                 i+l+l +g+  ++ ++TGsGK+  f+  
  EFC39720.1 483 INLTLeKGKLYCLIGNTGSGKSSLFSSI 510
                 66777466788999*********99865 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.031
                  TTCEEEEEESTTSSHHHHHHHHHHHHHHHS...............TTSTS-EEEEEESSHH.HHHHHHH.HHHHHTTTSTSEEEEEETTSSHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx...............xxxxxxxxxxxxxxxx.xxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   13 gggdvlvaaeTGsGKTlaflipvlqivyet...............kgktgpkalivePtre.Laeqtln.nlkkfkkyidlrvlliiggvaardqls 92  
                   g +v + ++ GsGK+   li +++ + e                  k+  + l++ P +  L   t++ nl  f +++d ++ + ++ v  +++++
  EFC39720.1 1094 PGTKVGIVGRSGSGKSSL-LISLFRFL-EAdsgnikidgynisdiGLKRLRQSLLIIPQQPvLFTGTIRyNLDIFNEFTDKEIWSALERVHLKNKIR 1188
                  566778888889999876.67777444.444565655555555553444467777777764255555541555555668866668899999999999 PP

                  HHHTTCSEEEEEHHHHHHHHHCTSSH.....CTTEEEEEEETHHHHHHTTTHHHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        DEAD   93 kldngvdivvgtpgrlddllstgkln.....lsqvrflVlDEadrlldqgfsdfinriln 147 
                   +++++d  v+  g  +++ +++ ++     l++ +++++DE   + d +    +++i++
  EFC39720.1 1189 SMEKKLDEPVTENGGNFSIGERQLVSlarciLRKAKIIIFDESTAFVDHQADALVQKIVR 1248
                  99999999999999999988766655556669999********99999988888888876 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.031        25       3      18 ..     494     509 ..     493     528 .. 0.89
   2 ?    2.2   0.0       0.2   1.6e+02       4      23 ..    1100    1119 ..    1097    1128 .. 0.82
   3 ?    0.1   0.0      0.93   7.5e+02      70     113 ..    1247    1292 ..    1198    1314 .. 0.76

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.031
                 EEE--SSSSHHHHHHH CS
       AAA_5   3 lLvGppGtgKselaer 18 
                 +L+G++G+gKs+l  +
  EFC39720.1 494 CLIGNTGSGKSSLFSS 509
                 9**********99876 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.2
                  EE--SSSSHHHHHHHGGGGB CS
       AAA_5    4 LvGppGtgKselaerlaaal 23  
                  +vG +G+gKs+l  +l ++l
  EFC39720.1 1100 IVGRSGSGKSSLLISLFRFL 1119
                  79**********98887777 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.93
                  EEESGGG--.HHHHHHHHHHHHSSEEE..-SSSEEE---....... CS
       AAA_5   70 vlDEverae.sevlnsLlslleerrllleeggelvkakndd.ller 113 
                  v +E+++a    v+ +L ++++ +++ ++e ge   + +++ ll++
  EFC39720.1 1247 VREEFKHATiITVAHRLDTIIDSDKIIVMEFGEILEVGSPKeLLKQ 1292
                  4567777777778888888888888888888888877777666665 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.045        37       3      20 ..     493     510 ..     491     513 .. 0.87
   2 ?    5.1   0.0     0.024        19       5      22 ..    1100    1117 ..    1097    1126 .. 0.83

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.045
                 EEEEC-TTTCHHHHHHHH CS
       NACHT   3 vilqGeaGsGKTtLlqkl 20 
                  +l G  GsGK+ L  ++
  EFC39720.1 493 YCLIGNTGSGKSSLFSSI 510
                 699***********9887 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.024
                  EEC-TTTCHHHHHHHHHH CS
       NACHT    5 lqGeaGsGKTtLlqklal 22  
                  + G++GsGK+ Ll +l +
  EFC39720.1 1100 IVGRSGSGKSSLLISLFR 1117
                  89***********98876 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.0      0.02        16      22      53 ..     480     510 ..     462     521 .. 0.78
   2 ?    4.1   0.0     0.036        30      30      54 ..    1092    1116 ..    1067    1121 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.02
      AAA_25  22 rrwlvkgllpagelallaGapgtGKttlaldl 53 
                 ++  +   l +g+l  l+G +g+GK+ l +++
  EFC39720.1 480 LK-NINLTLEKGKLYCLIGNTGSGKSSLFSSI 510
                 44.6677889****************998775 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.036
      AAA_25   30 lpagelallaGapgtGKttlaldla 54  
                  +  g+ + ++G++g+GK+ l+++l 
  EFC39720.1 1092 IDPGTKVGIVGRSGSGKSSLLISLF 1116
                  567788889*************985 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.0      0.29   2.4e+02      14      37 ..     487     509 ..     481     515 .. 0.79
   2 ?    7.0   0.0    0.0051       4.2      21     114 ..    1098    1248 ..    1089    1262 .. 0.68

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.29
      AAA_30  14 ltsgdrvavltGpAGtGKttalka 37 
                 l++  ++ +l G  G+GK+ + ++
  EFC39720.1 487 LEK-GKLYCLIGNTGSGKSSLFSS 509
                 344.46999**********98776 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0051
      AAA_30   21 avltGpAGtGKttalkalreaweaa.g.grviglAptgkaAkvLaeelgi.......eastiakllkrlk........................... 81  
                  + ++G+ G+GK+ +l +l + +ea+ g  ++ g+  +    k+L+++l i        + ti   l+  +                           
  EFC39720.1 1098 VGIVGRSGSGKSSLLISLFRFLEADsGnIKIDGYNISDIGLKRLRQSLLIipqqpvlFTGTIRYNLDIFNeftdkeiwsalervhlknkirsmekkl 1194
                  5689**************9999999655777888888888888887665433333333333333333332555555555556666777777777777 PP

      AAA_30   82 .....................grarlepgtllivDEagmvdtkqlaallkaaek 114 
                                       +r  l++++++i DE+     +q++al++++ +
  EFC39720.1 1195 depvtenggnfsigerqlvslARCILRKAKIIIFDESTAFVDHQADALVQKIVR 1248
                  788888888888888888877556667778888888888888888888877655 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       2.5     2e+03     153     201 ..     443     491 ..     410     496 .. 0.79
   2 ?    4.1   0.8     0.052        43      28      44 ..     495     511 ..     491     521 .. 0.85
   3 ?    7.2   0.1    0.0058       4.7      25      46 ..    1097    1118 ..    1088    1128 .. 0.85
   4 ?   -0.5   0.1       1.3   1.1e+03      50     124 ..    1220    1300 ..    1173    1317 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 2.5
       DUF87 153 ekeelrklknqaiarlldkledllrkggsfsnsstdliallleklekeg 201
                 ++ee++ l++++ + l d   ++++ ++s+++ s+ +++++   lek++
  EFC39720.1 443 KAEENKDLNDSISSPLVDFAIKFKNATISWGEHSSPILKNINLTLEKGK 491
                 567888899999999999999*********9999999999966665554 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.052
       DUF87  28 ilgsTGsGKSntvavLl 44 
                  +g TGsGKS + +++ 
  EFC39720.1 495 LIGNTGSGKSSLFSSIY 511
                 689********998885 PP

  == domain 3  score: 7.2 bits;  conditional E-value: 0.0058
       DUF87   25 HlAilgsTGsGKSntvavLlee 46  
                   ++i+g++GsGKS +  +L++ 
  EFC39720.1 1097 KVGIVGRSGSGKSSLLISLFRF 1118
                  589***********99999875 PP

  == domain 4  score: -0.5 bits;  conditional E-value: 1.3
       DUF87   50 kkgatililDpHGEYgkal.....ekllsekvkvitpspsakdkelkinpwsldpeelldllee.ddkpaaavqrsvleea 124 
                   ++a+i+i+D    +++ +     +k ++e++k+ t+   a      i+ +++ + e+ ++le+ + k++ ++++s ++++
  EFC39720.1 1220 LRKAKIIIFDESTAFVDHQadalvQKIVREEFKHATIITVAHRLDTIIDSDKIIVMEFGEILEVgSPKELLKQEDSNFYKL 1300
                  578889999988888888877777555555555555555557777788888888888888888875555555544444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1319 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1234  (0.068827); expected 358.6 (0.02)
Passed bias filter:                      680  (0.0379274); expected 358.6 (0.02)
Passed Vit filter:                        82  (0.0045736); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              22  [number of targets reported over threshold]
# CPU time: 1.12u 0.33s 00:00:01.45 Elapsed: 00:00:00.52
# Mc/sec: 7671.56
//
Query:       EFC39721.1  [L=251]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.1e-31  108.1   0.0    4.4e-29  102.1   0.0    2.2  1  2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_2  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  102.1   0.0   2.5e-33   4.4e-29       5     196 .]      77     248 ..      73     248 .. 0.80

  Alignments for each domain:
  == domain 1  score: 102.1 bits;  conditional E-value: 2.5e-33
  2OG-FeII_Oxy_2   5 ipnflsaeeaaellrelleegpfrqptilg.gkrvsvqqtllgplgwatdgpgyrysekesvdakplspfpeallrlverlvkaagpegwspnaa 98 
                     i nf+s+ +++ l++++l+++ + ++t++  gk+v + +  +      +              + ++s++pe l  l+er++k   +++++++ +
      EFC39721.1  77 ISNFVSKPDSKVLFNKILSTCTWKTKTYNYgGKDVISPREFC------G---------I--SSQSEWSKIPE-LISLKERIEK---FTNHTFTYC 150
                     556666666666666666666665555553244444444434......1.........1..23568999***.********98...99******* PP

  2OG-FeII_Oxy_2  99 lvnfYrdga.riglHqDkees.aleapivSlSLGasatfrfg.......kesreeeiiailLesGdllvmggesrkay.Hgvprikkdtapelel 183
                     ++n Y+dg+ +i +H+Dke+  + + pivS+SLG++++f+f+       k++++ +ii+  L++G+++vm+ e++++y H++p+ ++        
      EFC39721.1 151 FINKYKDGNdSIYWHSDKEKGlKKGCPIVSISLGQERDFQFRpkisknsKQQKDGNIIEKNLPDGSMVVMNYETQEYYeHSLPKRRN-------- 237
                     *******************776999****************99898887777888***********************999988888........ PP

  2OG-FeII_Oxy_2 184 eelrtrRinlTfR 196
                         + R+nlTfR
      EFC39721.1 238 --IHNIRLNLTFR 248
                     ..5789******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (251 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       729  (0.0406604); expected 358.6 (0.02)
Passed bias filter:                      365  (0.0203581); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.30s 00:00:00.86 Elapsed: 00:00:00.50
# Mc/sec: 1518.60
//
Query:       EFC39722.1  [L=894]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
  ------ inclusion threshold ------
      0.063   12.0   0.1       0.73    8.5   0.0    2.2  2  Glyco_hydro_15  Glycosyl hydrolases family 15


Domain annotation for each model (and alignments):
>> Glyco_hydro_15  Glycosyl hydrolases family 15
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.5   0.0   4.1e-05      0.73      87     135 ..     535     583 ..     531     669 .. 0.89
   2 ?    0.9   0.0    0.0085   1.5e+02     176     223 ..     833     889 ..     791     893 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.5 bits;  conditional E-value: 4.1e-05
                     CTS-BTTB-TTSCGGGG--EE-TTS-B--S-..-S--BTTHHHHHHHHH CS
  Glyco_hydro_15  87 agkvekfketqstkgLhakyftktgstvvGddewghlQlDatslyllal 135
                      +k++k+ke+qs+++L  +++  t + ++     +++Q+D+ + ++l l
      EFC39722.1 535 TEKSRKSKESQSKNSLSFEKKIETSDSFTSIVSIKKPQVDTMARFALHL 583
                     5799***************************************999977 PP

  == domain 2  score: 0.9 bits;  conditional E-value: 0.0085
                     --ECEEHH..HHHHHHHHHHHHHHHHHHCT-HH.........HHCCHHHHHHHHHHH CS
  Glyco_hydro_15 176 enqgeselnassvgmakAlleaideadlfgakg.........daqlvektkdeilnk 223
                      n+ ++ +na+s+   +  +eai+++++f +k+           +l+ek k +i ++
      EFC39722.1 833 RNEWQPYINATSLYWERKCDEAIAILNEFLDKSiengkadlpTINLLEKIKRQIDKE 889
                     56678899**********************999999988888888888888887765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (894 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       801  (0.0446762); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.27s 00:00:00.90 Elapsed: 00:00:00.45
# Mc/sec: 5919.23
//
Query:       EFC39723.1  [L=529]
Description: aldehyde dehydrogenase 2 family [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   2.5e-170  567.0   0.1   2.9e-170  566.7   0.1    1.0  1  Aldedh    Aldehyde dehydrogenase family


Domain annotation for each model (and alignments):
>> Aldedh  Aldehyde dehydrogenase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  566.7   0.1  1.6e-174  2.9e-170       1     462 []      50     516 ..      50     516 .. 0.97

  Alignments for each domain:
  == domain 1  score: 566.7 bits;  conditional E-value: 1.6e-174
                 EET-SS.SEEEEEETTTCEEEEEEE-B-HHHHHHHHHHHHHHHH.HHTTS-HHHHHHHHHHHHHHHHHTHHHHHHHHHHHH---HHHHHH.HHHHHHHH CS
      Aldedh   1 wveses.etievinPatgeviakvpaataedvdaavaaAkeafk.awaklpaeeRaeiLrkaadlleerkeelaeletletGkplaeara.eveeaidv 96 
                 +ve+++ +++ v+nPat+e+i+++++ata+dvd+av+ A+++f+  w++  +++R ++++k+adl+e++++ +a+le++++Gkp    r+ ++  ++++
  EFC39723.1  50 FVEGKEgKKFSVYNPATEEEICQISEATAADVDDAVRVARNTFEnVWRNYAPSQRVRLMNKWADLIERDADYIADLECIDNGKPRDMVRNvDIYLVLQC 148
                 567777577***********************************88***************************************************** PP

                 HHHHHHHHHHHSEEEEEECTTEEEEEEEEE-SEEEEEE-SSSCCHHHHHHHHHHHHTT-EEEEEE-TTSHHHHHHHHHHHHHTTS-TTSEEE--SSTCC CS
      Aldedh  97 lryyaelaeklegevlpssegklalvrrePlGvvgaItPWNfPlllaawklapalaaGNtvvlKPaeetplsalllaelfeeaglPkgvlnvvtgsgse 195
                 +ryya++a+k++g+++p++++ +a+++reP+Gv+g+I+PWNfPll+a+wk+ap+la+GN+ +lK ae+tplsal++a+l++eag+P+gv++v++g g++
  EFC39723.1 149 IRYYAGWADKINGKTIPVDSDFFAYTQREPVGVCGQIVPWNFPLLMATWKWAPCLATGNVSILKTAEQTPLSALYVAKLAHEAGFPPGVIQVLSGFGET 247
                 ******************99******************************************************************************* PP

                 HHHHHHH-TTESEEEEES-HHHHHHHHHH.HHCTTSEEEEEE---EEEEE-TTS.H...HHHHHHHHHHHHHGGGGTSTTSEEEEEEEHHHHHHHHHHH CS
      Aldedh 196 vgealvehpevdkvsftGstevgrkiaka.aaknlkrvtlElGGknplivleda.D...ldkaveaivkgafgnaGQvCiaasrllvqesiydefvekl 289
                 vg+al++h +vdk+sftGstevg+ki+ a +++nlkrvtlElGGk++liv+ d+ D   l+kav+ + +g+f+n+GQvC++ sr++v ++iy++f++  
  EFC39723.1 248 VGNALTHHMDVDKISFTGSTEVGKKILGAsSKTNLKRVTLELGGKSALIVMGDVkDratLEKAVNIANQGTFFNQGQVCTCSSRVFVASNIYEDFLKIS 346
                 *****************************66699***************98776434449*************************************** PP

                 HHHHHT--BS-TTSTT-SB---SSHHHHHHHHHHHHHHHHTTSEEEE-TTE.SB-SSSTTEE--EEEES-TTTSHHHHS---SSEEEEEEES..SHHHH CS
      Aldedh 290 veaakklkvgdpldedtdvGPliseaqlekvekyveeakeegaklllGgereeaglekgyfvePtvlanvtpdmriaqeEiFGPVlsvikfk..deeea 386
                 +e a+k  vg+p+d++t+ G+++se+q++k+++y+e +k++  +l++Gg   e+  +kgyfv+Ptv+a+v++ ++iaqeEiFGPV+sv+kf+  ++e+a
  EFC39723.1 347 KELAEKRVVGNPFDSKTEQGAQVSEEQFNKIMSYIEYGKNN-TRLVTGG---ERAHAKGYFVKPTVFADVEDTHKIAQEEIFGPVMSVLKFDhdNVEDA 441
                 ***************************************95.6******...7789***********************************97789*** PP

                 HHHHHSSSEESEEEEE-SBHHHHHHHHHHS-SSEEEESSSST--TTTSEB--CGGGEES-BSHHHHHHHTEEEEEE CS
      Aldedh 387 ieiaNdteyGLaagvftkdleraervaerleaGnvyiNdsttgaaealpfgGvkqSglGreggkegleeytevktv 462
                 i+ aN++eyGLaagv+t dl++a+rv++ l+aG++++N+++++  +   fgG+k+Sg Gr+ g+++l+eyte k+v
  EFC39723.1 442 IRRANKSEYGLAAGVITHDLNQAHRVTSGLRAGTIWVNTWNAFFSNI-EFGGYKMSGQGRDLGEHALDEYTENKSV 516
                 *******************************************9999.************************9987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (529 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       784  (0.043728); expected 358.6 (0.02)
Passed bias filter:                      629  (0.0350828); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 3255.36
//
Query:       EFC39724.1  [L=1150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.8e-50  170.6   0.2    4.6e-48  163.8   0.1    2.6  2  Pkinase_Tyr      Protein tyrosine kinase
    9.2e-47  159.6   0.2    1.7e-46  158.7   0.2    1.4  1  Pkinase          Protein kinase domain
    1.1e-13   51.4  32.5    3.9e-09   36.5  17.5    3.9  3  Beta_helix       Right handed beta helix region
    3.3e-07   29.8  37.7    9.4e-06   25.1  19.3    3.3  4  NosD             Periplasmic copper-binding protein (NosD)
    1.7e-05   24.0   0.2      4e-05   22.7   0.2    1.6  1  Haspin_kinase    Haspin like kinase domain
  ------ inclusion threshold ------
       0.03   14.2   0.0      0.052   13.5   0.0    1.3  1  APH              Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.78   2.3e+03     103     122 ..      36      55 ..      26      58 .. 0.75
   2 !  163.8   0.1   1.5e-51   4.6e-48       2     259 .]     846    1141 ..     845    1141 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.78
                  HHHHHHHHHHHHHHHHHHHT CS
  Pkinase_Tyr 103 kdllsfalqvAkGmeyLesk 122
                  ++ + +  +++k+meyL+ +
   EFC39724.1  36 TSQFLVNNEISKAMEYLQFN 55 
                  555667789********865 PP

  == domain 2  score: 163.8 bits;  conditional E-value: 1.5e-51
                   EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHH..HHHHT CS
  Pkinase_Tyr    2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlk..fLrkk 95  
                    + kk++eG  G V++gt+k       ++Va+Kt+k+++++  ++++ +e++++ ++++p+i++++gvc+ e++++++te++++G+L+   +L + 
   EFC39724.1  846 DIVKKVAEGGNGVVYKGTWK------GIEVAIKTIKAKNES--RDDFENEISLLASIRNPHILNFYGVCVTENETFMITEFLENGSLEGiiYLSRI 933 
                   57799***************......9********665555..69******************************************964488888 PP

                   CTTTSBHHHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE......EE CS
  Pkinase_Tyr   96 ekekltlkdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk......ft 183 
                    + kl+++++l++ ++vA Gm+yL+s +  +vHrdl   N+Ll++++++k++DfGL+r++ ++++ ++ +++   + +++pE+++  +        
   EFC39724.1  934 GQFKLSFHEKLRILYEVAIGMDYLHSLTpkIVHRDLKPGNILLDKDMHCKVCDFGLSRTV-NQNTNHSITRNVGTLFYLSPEMFEIDQtkvdphNV 1028
                   999**********************96444******************************.77777888889999********9877767888788 PP

                   HHHHHHHHHHHHHHHHTTSSGT......................................TTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHH CS
  Pkinase_Tyr  184 sksDvWsfGvllwEiftlgesp......................................ypglkneevleklkegkrlekpekcpeelyelmkkc 241 
                   sk D +sfG+++wE+f     p                                      ++++++ +    + e+ +  k +++  e  el k+c
   EFC39724.1 1029 SKIDTYSFGIIMWELFFEL-APftenrktvrmlhedensnnlntinmlhlvskgkrpsipFESIEEVREWLLIYEEDKKFKGANIVLEYFELTKQC 1123
                   99*************9843.4457999****************************99988888877777777788888888899************ PP

                   T-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  242 weedpeeRptfselvekl 259 
                   w+e+p+ Rp+f+ +v+kl
   EFC39724.1 1124 WSEQPSTRPEFNVIVKKL 1141
                   **************9987 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  158.7   0.2   5.8e-50   1.7e-46       4     261 ..     848    1140 ..     845    1142 .. 0.83

  Alignments for each domain:
  == domain 1  score: 158.7 bits;  conditional E-value: 5.8e-50
                  EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH....HHSS-- CS
     Pkinase    4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle....rkgsls 96  
                  ++k+ eG++G+Vyk++  ++g +vA+K+ik ++++ +   ++ +Ei++l++++ p+i+++y+v+ +++e ++++e++e+g+l+ ++      + +ls
  EFC39724.1  848 VKKVAEGGNGVVYKGT--WKGIEVAIKTIKAKNESRD---DFENEISLLASIRNPHILNFYGVCVTENETFMITEFLENGSLEGIIYlsriGQFKLS 939 
                  68999***********..9***********9988874...489****************************************99988865555677 PP

                  HHHHHHHHHHHHHHHHHHHHTT..EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS..BCTTTSCGGGS-HHHH.....TTSCB.SHHHHHHHH CS
     Pkinase   97 eeeakkiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk..ltsfvgtseYlAPEvl.....keney.skkvDvWsl 183 
                   +e  +i+++++ g++ylHs    i+HrDlKp NiL+d++ + K++DFGl++ ++++++   t  vgt  Yl+PE+      k  ++  +k+D +s 
  EFC39724.1  940 FHEKLRILYEVAIGMDYLHSLTpkIVHRDLKPGNILLDKDMHCKVCDFGLSRTVNQNTNhsITRNVGTLFYLSPEMFeidqtKVDPHnVSKIDTYSF 1036
                  778889*************87555*******************************999999***************99876544566689******* PP

                  HHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.....SHH...HHHTTS.............................-HHHHHHHHHHT- CS
     Pkinase  184 Gvilyelltgkppfsgekgkekvekeldqlekilkilg.....etkeklpeasei.............................seeakdllkkllk 246 
                  G+i++el+++  pf +++++ ++ +e ++  ++  i       + k                                        e  +l k++++
  EFC39724.1 1037 GIIMWELFFELAPFTENRKTVRMLHEDENSNNLNTINMlhlvsKGK--------RpsipfesieevrewlliyeedkkfkganiVLEYFELTKQCWS 1125
                  ***************6665555544444433222222232333222........02234444577799999999999999999999999******** PP

                  SSGCCSTTHHHHHTS CS
     Pkinase  247 kdpkkRltaeellqh 261 
                  ++p++R+ ++ ++++
  EFC39724.1 1126 EQPSTRPEFNVIVKK 1140
                  ******999888775 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.1   8.4   9.2e-05      0.27      23     139 ..     273     400 ..     217     401 .. 0.66
   2 !   36.5  17.5   1.3e-12   3.9e-09       4     139 ..     381     524 ..     377     543 .. 0.84
   3 !   11.9   0.2     5e-05      0.15      78     138 ..     546     613 ..     526     636 .. 0.76

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 9.2e-05
                 S-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---....SEEE-TT--S--EEES-EEES-SS-SEE-TT-S-.-EEES-EEESTT.. CS
  Beta_helix  23 gyGiylrgssnvvienneiannsgsGiyilgssnntisnntisdnn....gggialfgasnnlienneitdnggsGiylnyssn.ntienNiidnna.. 114
                 +   ++ + +n +ien+ +++     +  ++++n+ i+n+t+ + +    +  +++ +++   + n+++ +  +  + +  s+  ++i  +i++nn+  
  EFC39724.1 273 RLRWTVSSVTNLIIENSLFED-FLVEMTFKQVTNVLIRNSTFIRDYldykEESVNALQGNSFRVINCTFQHAYS--FLFVRSYIfVSIDSSIVSNNQlm 368
                 444456677777888777777.8888888888888888888855554444556677777777777777777743..33332222345555555555555 PP

                 .......--SEE---TT---EEES-EEES-SS CS
  Beta_helix 115 .......gsGividdsssnvtvtnNtitnnkg 139
                         +Gi   +s+ +v v+n+ ++nn g
  EFC39724.1 369 kenlisvFYGIIAIQSCITVMVSNSQFSNNEG 400
                 54455554565555555577788888888875 PP

  == domain 2  score: 36.5 bits;  conditional E-value: 1.3e-12
                 EE-SS-E.EEESEEEES-....SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-T CS
  Beta_helix   4 singssnvtiknntisns....ggyGiylrgssnvvienneiannsgsGiyilgssnntisnntisdnngggialfgasnnlienneitdnggsGiyln 98 
                  i ++ +v ++n+++sn+     ++++yl + +  +++n+ ++nns s i  ++ +n  ++n + +         +  sn  +e+n++++ g  Giy++
  EFC39724.1 381 AIQSCITVMVSNSQFSNNegyeRASALYLSDVNVFHVRNCQFTNNSASSIFSNSYPNRMFDNDKSYYW-------YTVSNCKFEGNTCNKEGC-GIYIS 471
                 55555567777777777777779******************************999999999998844.......599*************87.***** PP

                 T-S--EEES-EEESTT....--SEE---TT---EEES-EEES-S.........S CS
  Beta_helix  99 yssnntienNiidnna....gsGividdsssnvtvtnNtitnnk.........g 139
                 +s ++ti+nNi+ nn+    g++++i  ++ + ++ nN + +nk          
  EFC39724.1 472 DSIDLTIQNNIFLNNTaqygGAALFIKIGA-RAVILNNLFIGNKvlynnllrqP 524
                 ******************************.9999********97766666663 PP

  == domain 3  score: 11.9 bits;  conditional E-value: 5e-05
                 S--EEES-EEES-....SS-SEE-TT-S--EEES-EEESTT...--SEE---TT.---EEES-EEES-S CS
  Beta_helix  78 snnlienneitdn....ggsGiylnyssnntienNiidnna...gsGividdss.snvtvtnNtitnnk 138
                 s + +  n++++n    gg  +++   s + i+n+++ +n+   g ++++++ s  ++++++N+++ n+
  EFC39724.1 546 SESKLLANTFINNealyGG-SLFFVRESLVEISNSTFIGNKakrGGAMFYYSPSvEQTEIFDNVFKENV 613
                 5555566777777555333.57777899**************986666666666899999******998 PP

>> NosD  Periplasmic copper-binding protein (NosD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.4      0.29   8.5e+02      61     124 ..     252     314 ..     224     345 .. 0.55
   2 !   10.2  10.5   0.00011      0.33      25     143 ..     309     442 ..     279     444 .. 0.82
   3 !   25.1  19.3   3.1e-09   9.4e-06      20     174 ..     358     515 ..     326     524 .. 0.86
   4 !   20.1  10.4   1.1e-07   0.00032      32     188 ..     437     631 ..     435     638 .. 0.66

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.29
        NosD  61 yGihlensesntiedntlssnesGialmsssnntlenNtisnnenyGillsdssnntisnNtis 124
                 yG ++++    +++++++ +++   +++s +n ++en+ + +     ++ ++ +n  i+n t+ 
  EFC39724.1 252 YGEYYVTGLTAIYNNSEIHETRLRWTVSSVTNLIIENSLFEDFLV-EMTFKQVTNVLIRNSTFI 314
                 444444444444445555555555555555544555555555444.555555555545544443 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00011
        NosD  25 egseisnneisnsrdgilldnssnntitgntienl.....ryGihlensesntiedntlssne.....sGialmsssnn.tlenNtisnnen....yGi 108
                 ++s+    +++  ++++ + + +++++ ++t+++        +  +++ +s+++++n+l + +     +Gi+  +s+ + +++n+ +snne+       
  EFC39724.1 309 RNSTFIRDYLDYKEESVNALQGNSFRVINCTFQHAysflfVRSYIFVSIDSSIVSNNQLMKENlisvfYGIIAIQSCITvMVSNSQFSNNEGyeraSAL 407
                 56666778888888899999999999999999998777775555555555578888887777668889*********888************9998899 PP

        NosD 109 llsdssnntisnNtisnnnkGiflensssntitgN 143
                 +lsd +   ++n +++nn++   ++ns  n++ +N
  EFC39724.1 408 YLSDVNVFHVRNCQFTNNSASSIFSNSYPNRMFDN 442
                 ****************8888888888899998888 PP

  == domain 3  score: 25.1 bits;  conditional E-value: 3.1e-09
        NosD  20 qlensegseisnneisnsrdgi.lldnssnntitgntienl.....ryGihlensesntiedntlssnesGialmsssnntlenNtisnnenyGillsd 112
                   + ++++++ +++++++ +gi +++++ ++ +++++++n+     +++++l++ +   ++++++++n++  ++++s       N++ +n++ + +  +
  EFC39724.1 358 DSSIVSNNQLMKENLISVFYGIiAIQSCITVMVSNSQFSNNegyerASALYLSDVNVFHVRNCQFTNNSASSIFSNSY-----PNRMFDNDK-SYYWYT 450
                 445568888888888888888878888899999999999999999999*********************999999*99.....899999999.9***** PP

        NosD 113 ssnntisnNtisnnnkGiflensssntitgNriesn.qkiGil..llsssegntiynNyFinnse 174
                  sn++ ++Nt  +++ Gi++++s + ti++N + +n  ++G    +++ + +  i nN Fi+n++
  EFC39724.1 451 VSNCKFEGNTCNKEGCGIYISDSIDLTIQNNIFLNNtAQYGGAalFIKIGARAVILNNLFIGNKV 515
                 ***********************99999999999996355554447999999**********986 PP

  == domain 4  score: 20.1 bits;  conditional E-value: 1.1e-07
        NosD  32 neisnsrdgilldnssnntitgntienlryGihlensesntiedntlssne.....sGialmsssnntlenNtisnnen................yGil 109
                 n++ ++ ++ + ++ sn++++gnt++++  Gi++++s + ti++n++ +n+     ++++++   + ++ nN +++n+                     
  EFC39724.1 437 NRMFDNDKSYYWYTVSNCKFEGNTCNKEGCGIYISDSIDLTIQNNIFLNNTaqyggAALFIKIGARAVILNNLFIGNKVlynnllrqpastfyygG--- 532
                 566677777788899999999999999999999999999999999999999885323333344445599999999999886555555555555440... PP

        NosD 110 lsdssn...................ntisnNtisnnnkGiflens....ssntitgNriesnqkiGilllsssegntiynNyFinnsenvkydgsn... 182
                      +                   nt  nN++++ ++ +f+++s    s++t+ gN+ ++  +  ++   s e+ +i++N F +n  ++ +d  +   
  EFC39724.1 533 -----GgavsiittqlglseskllaNTFINNEALYGGSLFFVRESlveiSNSTFIGNKAKRG-GAMFYYSPSVEQTEIFDNVFKENVAEIGNDLLTsvv 625
                 .....044444445556666333334444444455566666666666666666666666666.66677788889999******8888877776444455 PP

        NosD 183 nneWnt 188
                    W++
  EFC39724.1 626 ALDWDN 631
                 566655 PP

>> Haspin_kinase  Haspin like kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.2   1.4e-08     4e-05      96     263 ..     839     999 ..     787    1013 .. 0.64

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 1.4e-08
  Haspin_kinase  96 ilneadlasllndseklssevyqtkekdkevvlKvipl..evledvtiskelslkelkslklvkgtypglllllqdkvlkekpdfyseqqlflvll 189
                    i+ ++d++ +++ +e+  + vy+ + k  ev++K i    e  +d++ + ++ l+  ++ ++++    g+ +  ++  + ++  f +++ l  +++
     EFC39724.1 839 IISPKDIDIVKKVAEGGNGVVYKGTWKGIEVAIKTIKAknESRDDFENE-ISLLASIRNPHILNFY--GVCVTENETFMITE--FLENGSLEGIIY 929
                    5555555555555555555555555555555555555544444444332.2333444444444432..44444444444433..556666666666 PP

  Haspin_kinase 190 lkdkGtdLeevklkswkqalsifwqivkiL.yvaEtkfeFEHRdLhldniLvdknlnvtlidlklsRlessegkv 263
                    l   G    ++kl s+++ l+i+++++  + y+     +  HRdL+ +niL+dk ++  ++d+ lsR  +++ + 
     EFC39724.1 930 LSRIG----QFKL-SFHEKLRILYEVAIGMdYLHSLTPKIVHRDLKPGNILLDKDMHCKVCDFGLSRTVNQNTNH 999
                    65544....4554.677888999999887733444567899**************************98655554 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   1.7e-05     0.052     164     196 ..     960     990 ..     942     993 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1.7e-05
                 S-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 164 lptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                 l + ++H+Dl+pgN+l+d  d ++  v Df+++
  EFC39724.1 960 LTPKIVHRDLKPGNILLD-KDMHC-KVCDFGLS 990
                 66779*************.44544.58888876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       682  (0.0380389); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.97u 0.35s 00:00:01.31 Elapsed: 00:00:00.58
# Mc/sec: 5993.98
//
Query:       EFC39725.1  [L=175]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.036   12.8   0.0      0.042   12.6   0.0    1.1  1  DUF3808   Protein of unknown function (DUF3808)


Domain annotation for each model (and alignments):
>> DUF3808  Protein of unknown function (DUF3808)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   2.4e-06     0.042     296     339 ..      41      83 ..      33     126 .. 0.87

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 2.4e-06
     DUF3808 296 ieesqselkqvkhlclfelaltlvylheykeaaesfleLlklsk 339
                 i + ++++k ++ +++++++    +++ey + +++ ++Ll++++
  EFC39725.1  41 I-KLEDPQKTFHMMIVWDKTKPENHQLEYTTIMNDLKKLLSENN 83 
                 5.678899********************************9997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (175 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       554  (0.0308997); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.52
# Mc/sec: 1018.51
//
Query:       EFC39726.1  [L=766]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.8e-51  173.2   1.1    1.5e-50  172.0   1.1    1.6  1  Pkinase         Protein kinase domain
    2.5e-34  118.8   0.4    4.6e-34  117.9   0.4    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
     0.0043   16.4   0.4       0.01   15.2   0.1    1.7  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
     0.0066   15.3   0.0     0.0066   15.3   0.0    2.5  2  Pkinase_fungal  Fungal protein kinase
  ------ inclusion threshold ------
        0.1   13.0   0.6       0.31   11.4   0.1    2.1  2  DUF3874         Domain of unknonw function from B. Theta Gene
       0.15   12.6   0.7       0.88   10.1   0.0    2.6  3  SF3A3           Pre-mRNA-splicing factor SF3A3, of SF3a compl


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  172.0   1.1     5e-54   1.5e-50       4     246 ..     508     765 ..     505     766 .] 0.88

  Alignments for each domain:
  == domain 1  score: 172.0 bits;  conditional E-value: 5e-54
                 EEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS.--HHHHH CS
     Pkinase   4 leklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladllerkgs.lseeeak 101
                 +++lG GsfG+V+ +++++ ++++AvKki  + +++ k+ k+ +E +i+k+l+h+nivr+++v  ++d  ++++e+++gg+l+++l+r  + lse+ ++
  EFC39726.1 508 IKTLGVGSFGNVMLCFDSNANEMMAVKKILYSAESQVKQ-KIEKETTIMKSLNHENIVRFKGVEFSNDFCFILMEFLSGGSLKQVLKRMNKgLSEAVVQ 605
                 789*****************************9999886.9**********************************************55555******* PP

                 HHHHHHHHHHHHHHHTT...EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS............BCTTTSCGGGS-HHHH.TTSCB..SHHHHHHH CS
     Pkinase 102 kiakqilegleylHskg...iiHrDlKpeNiLidekgelKitDFGlakelesssk............ltsfvgtseYlAPEvl.keney..skkvDvWs 182
                  ++kqil +l+ylH+ +   i HrDlK+eNiL+++ + +K++DFG ak + ++s+            ++ ++gt  +l+ E l +e+ y  s+  D+Ws
  EFC39726.1 606 LYLKQILVALKYLHEDRdepIYHRDLKSENILLKNAEIIKLADFGEAKLICKNSHldksrqdgsltkTKAMTGTIPFLSIEQLrGETCYkrSHMPDIWS 704
                 **************877788**************9999************999999**********9999*************744555457778**** PP

                 HHHHHHHHHHSS-STTTSSHHHHHHHHHHT..HHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT- CS
     Pkinase 183 lGvilyelltgkppfsgekgkekvekeldq..lekilkilgetkeklpeaseiseeakdllkkllk 246
                 lG++++e+l g++++ +      + ++l++      ++i ++     + +s is++++dl++k+l+
  EFC39726.1 705 LGMTILEMLIGRNIWFSL-----YPANLTTeyQYVEFMINNTHLIYENIPSYISPQLRDLITKCLS 765
                 **************9933.....333333311233345555555666788999***********96 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  117.9   0.4   1.5e-37   4.6e-34       4     242 ..     508     764 ..     506     766 .] 0.83

  Alignments for each domain:
  == domain 1  score: 117.9 bits;  conditional E-value: 1.5e-37
                  EEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTSB CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekeklt 101
                   k+lG G+fG+V+ +  +    ++++  avK++  +a+++ k+++ +e++imk+l+h+niv++ gv  +++  +i++e+++gG+L++ L++  ++ l+
   EFC39726.1 508 IKTLGVGSFGNVMLCFDS----NANEMMAVKKILYSAESQVKQKIEKETTIMKSLNHENIVRFKGVEFSNDFCFILMEFLSGGSLKQVLKRM-NKGLS 600
                  689**********99877....89999****************************************************************9.99999 PP

                  HHHHHHHHHHHHHHHHHHHHTT...EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEE.........EETTSSTSGGGGS-HHHHHHSEEEHHH. CS
  Pkinase_Tyr 102 lkdllsfalqvAkGmeyLeskk...lvHrdlaarNvLlsenkvvkisDfGLardiekddey.........vkkeeaklpvkWmapEslkekkftsks. 186
                     +  +  q+  +++yL++ +   + Hrdl + N+Ll++ +++k++DfG a+ i k+++          +k++  +  + ++++E l+ +++ ++s 
   EFC39726.1 601 EAVVQLYLKQILVALKYLHEDRdepIYHRDLKSENILLKNAEIIKLADFGEAKLICKNSHLdksrqdgslTKTKAMTGTIPFLSIEQLRGETCYKRSh 698
                  999999************98655559************************9999866655543333444455566667899********999655554 PP

                  ..HHHHHHHHHHHHHTTSSGT....TTTS..HHHHHHHHHHTTEES...-BBTTSBHHHHHHHHHHT CS
  Pkinase_Tyr 187 ..DvWsfGvllwEiftlgesp....ypgl..kneevleklkegkrl...ekpekcpeelyelmkkcw 242
                    D+Ws G+++ E++  g++     yp    ++ + +e++ ++++l   + p++++++l +l++kc+
   EFC39726.1 699 mpDIWSLGMTILEMLI-GRNIwfslYPANltTEYQYVEFMINNTHLiyeNIPSYISPQLRDLITKCL 764
                  55************98.66543344333223667777777666664333679999999999999997 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0      0.83   2.5e+03      55      75 ..     447     467 ..     396     468 .. 0.65
   2 !   15.2   0.1   3.4e-06      0.01      92     173 ..     576     656 ..     534     668 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 0.83
         Kdo  55 rtravrEfrllkrLeeagvav 75 
                 + +   E++++k+L+ a+v+v
  EFC39726.1 447 EYKQWLEVDNIKELQGAKVKV 467
                 455567899999999888887 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 3.4e-06
         Kdo  92 AlllterlegaqdLedllakwae.laeelkrallkavgrliaklhr...agvnHadlyaknillqqeeeeeaeiwliDldkarlrl 173
                  ++l+e l g  +L+++l++ ++ l+e++ +  lk++  + + lh+     ++H+dl   nill+++e     i l D+  a+l  
  EFC39726.1 576 CFILMEFLSG-GSLKQVLKRMNKgLSEAVVQLYLKQILVALKYLHEdrdEPIYHRDLKSENILLKNAE----IIKLADFGEAKLIC 656
                 5899999998.59*******999**********************7322569**************99....77788887766655 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -8.0   9.0         6   1.8e+04     236     299 ..     265     348 ..     120     363 .. 0.54
   2 !   15.3   0.0   2.2e-06    0.0066     318     391 ..     614     696 ..     594     705 .. 0.68

  Alignments for each domain:
  == domain 1  score: -8.0 bits;  conditional E-value: 6
  Pkinase_fungal 236 krkvvsssssqe...................lsskaevklkksesskkvekrsvdssvstskrsr.................lenrvhrrlvisp 294
                     k+++ s+ss++e                   +s+ a+ ++++ +       ++v                            l+ +  ++++ s 
      EFC39726.1 265 KNDSPSNSSESEeslllvpsktrsvspsslnTSPPAAPANTATNL------KKV----------VtnvkntnsektqtthayLKRKSISFVISSA 343
                     111111111111233444444444433332222222222222222......222..........0222222222222344444445555555555 PP

  Pkinase_fungal 295 vGkpi 299
                        + 
      EFC39726.1 344 TTSKS 348
                     44444 PP

  == domain 2  score: 15.3 bits;  conditional E-value: 2.2e-06
  Pkinase_fungal 318 ghrsLfl..kagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesga.........rertGTleFmaievlkgee...H 391
                     +++ L++  +  i HrD   +Nil+      + +   L+D+  ak + ++s+ +++         +  tGT++F++ie l+ge     
      EFC39726.1 614 ALKYLHEdrDEPIYHRDLKSENILLK-----NAEIIKLADFGEAKLICKNSHLDKSrqdgsltktKAMTGTIPFLSIEQLRGETcykR 696
                     55666651145699************.....455666777766665554333332222233444589**************8554442 PP

>> DUF3874  Domain of unknonw function from B. Theta Gene description (DUF3874)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.1    0.0001      0.31       4      31 ..     124     151 ..     121     168 .. 0.91
   2 ?   -2.7   0.0       2.6   7.7e+03      27      43 ..     254     271 ..     251     274 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.0001
     DUF3874   4 aeelfkscFraaeeeeegewlsaaeIfe 31 
                  e +f+s F++a+eeee+++l  +e++ 
  EFC39726.1 124 KENVFNSSFKFASEEEEAKYLDMVEVMT 151
                 599******************9999975 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.6
     DUF3874  27 aeIfevLkkknp.aalrg 43 
                 ++If+  +kk++  ++++
  EFC39726.1 254 SQIFKNTQKKSKnDSPSN 271
                 789999999998555555 PP

>> SF3A3  Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1       1.6   4.6e+03      18      35 ..      60      75 ..      36      96 .. 0.64
   2 ?   10.1   0.0   0.00029      0.88       1      45 [.     133     179 ..     133     193 .. 0.72
   3 ?   -3.5   0.0       5.3   1.6e+04      17      25 ..     447     455 ..     436     466 .. 0.59

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.6
       SF3A3 18 yeeylnlkeikldYlqYL 35
                +++yl+ ke    Y q+L
  EFC39726.1 60 HKSYLKSKE--DVYNQFL 75
                444444442..2344444 PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00029
       SF3A3   1 lFsgeEqyGkylDLnelyeeylnlkeik..ldYlqYLesfdkfseip 45 
                 +F  eE+  kylD+ e+ +ey + + ++   + ++ ++s+++++++p
  EFC39726.1 133 KFASEEEEAKYLDMVEVMTEYTDSDFLNstSSSISSIRSISSIKSLP 179
                 599*******************9985433455555566666666666 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 5.3
       SF3A3  17 lyeeylnlk 25 
                  y+++l+++
  EFC39726.1 447 EYKQWLEVD 455
                 244444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (766 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1423  (0.0793686); expected 358.6 (0.02)
Passed bias filter:                      418  (0.0233142); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.52
# Mc/sec: 4420.79
//
Query:       EFC39727.1  [L=371]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.3e-43  148.6   0.2    3.5e-26   92.1   0.0    2.2  2  CTP_transf_like  Cytidylyltransferase-like
    2.8e-07   30.6   2.0     0.0066   16.4   0.1    3.4  2  FAD_syn          FAD synthetase


Domain annotation for each model (and alignments):
>> CTP_transf_like  Cytidylyltransferase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   92.1   0.0   3.9e-30   3.5e-26       2     142 ..      20     146 ..      19     147 .. 0.95
   2 !   54.6   0.1   1.4e-18   1.3e-14       1      93 [.     215     306 ..     215     363 .. 0.86

  Alignments for each domain:
  == domain 1  score: 92.1 bits;  conditional E-value: 3.9e-30
                      EEE--TT--HHHHHHHHHHHHHSSES.EEEEEESSTHCSST-.SCSSTHHHHHHHHHHHTTCTTEEEEEEESEHHHHHHHTTTTEEEEEEEHHH CS
  CTP_transf_like   2 agGtFDpiHlGHlrlleqakklleed.livgvpsdeppkkkk.kplasaeeRlemlelakevdevisvdpweltrevlkklkpdklylvigadv 93 
                      ++G+FD+ H+GH+++++qa +l+ +  l+vgv+sde+  + k +++++a+eR+e+++ +k+vd vi+++p++++ e lkk+++d  y v+g+d 
       EFC39727.1  20 LDGCFDMMHFGHANVIRQAYNLFPNVkLLVGVHSDEEILRHKgPTIMKANERYEHVRSCKWVDGVIEDAPYVTDLEMLKKYNVD--YCVHGDDI 111
                      79************************************99977*****************************************..******96 PP

                      HHHHHCHHHHHHHHHHHHHEEEEEEHTTCEEEEEEECCTTTCSHHHHHH CS
  CTP_transf_like  94 ledfsewkeleeilgnvklvvvsrpekqanvllkaekrtngiSstkire 142
                        +f  +++ e+ ++  + ++           ++  +rt+g+S+t+i+ 
       EFC39727.1 112 --SF--DENGEDSYKAIRQAGL----------MMIVPRTEGVSTTDIIG 146
                      ..55..89*******9999999..........88889**********86 PP

  == domain 2  score: 54.6 bits;  conditional E-value: 1.4e-18
                      EEEE--TT--HHHHHHHHHHHHHSSESEEEEEESSTHCSST-...SCSSTHHHHHHHHHHHTTCTTEEEEEEESEHHHHHHHTTTTEEEEEEEH CS
  CTP_transf_like   1 lagGtFDpiHlGHlrlleqakklleedlivgvpsdeppkkkk...kplasaeeRlemlelakevdevisvdpweltrevlkklkpdklylviga 91 
                      +++G FD++H GH++ l+ akkl+++ livg++ d++  ++k   +p+++ +eRl  +  +++vd+vi  +p+ +t+++++  k++  ++v g 
       EFC39727.1 215 YVDGAFDMFHTGHIEFLKAAKKLGDY-LIVGLHEDKVISQFKgphHPIMNIHERLLSVLSCRYVDDVIIGAPFIVTQDLVDVMKIN--IVVSGT 305
                      689***********************.**************6699********************************999999999..665554 PP

                      HH CS
  CTP_transf_like  92 dv 93 
                       v
       EFC39727.1 306 -V 306
                      .4 PP

>> FAD_syn  FAD synthetase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.1   7.4e-07    0.0066       4     134 ..      13     128 ..       9     141 .. 0.71
   2 !    8.0   0.2   0.00028       2.5      10      33 ..     215     238 ..     209     282 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 7.4e-07
     FAD_syn   4 edegavvtlGnFDGvHlGHqallkkaveaakekglpsvvvtFephPrevlakekaparLttleeklelleelg.vdavlvvdFtkefaelsaeeFiekl 101
                 ++++++   G FD +H GH +++++a ++  + +  ++v + +   +e+l+  ++  ++++ +e++e ++++  vd v+               ++++l
  EFC39727.1  13 NTTKTIWLDGCFDMMHFGHANVIRQAYNLFPNVK--LLVGVHSD--EEILR--HKGPTIMKANERYEHVRSCKwVDGVIE-----------DAPYVTDL 94 
                 555566666******************9985544..44444443..56676..667779999999999999887787763...........33333332 PP

     FAD_syn 102 ..lveklkvkavvvGfdfrfGkkregdvellkelg 134
                   l+ k++v + v G+d +f +++e++ + ++++g
  EFC39727.1  95 emLK-KYNVDYCVHGDDISFDENGEDSYKAIRQAG 128
                 2044.788888888888888888888888877765 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00028
     FAD_syn  10 vtlGnFDGvHlGHqallkkaveaa 33 
                  + G+FD +H GH + lk a+++ 
  EFC39727.1 215 YVDGAFDMFHTGHIEFLKAAKKLG 238
                 5559**************999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (371 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       455  (0.0253779); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.52
# Mc/sec: 2163.59
//
Query:       EFC39728.1  [L=388]
Description: hypothetical protein NAEGRDRAFT_81204 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (388 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       825  (0.0460148); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 2269.96
//
Query:       EFC39729.1  [L=814]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-27   95.1   2.4    2.5e-26   91.7   0.3    3.3  3  DUF4209   Domain of unknown function (DUF4209)


Domain annotation for each model (and alignments):
>> DUF4209  Domain of unknown function (DUF4209)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.1      0.67   1.2e+04      28      45 ..      76      96 ..      61     105 .. 0.65
   2 !   91.7   0.3   1.4e-30   2.5e-26       1      89 []     200     296 ..     200     296 .. 0.96
   3 ?    1.2   0.0     0.024   4.3e+02      44      74 ..     465     494 ..     452     515 .. 0.73

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 0.67
     DUF4209 28 s...dlLaseelkeilgeela 45
                    +++++++l e+l++++ 
  EFC39729.1 76 YedvKIMNEKKLYEWLESKME 96
                244567888888888877765 PP

  == domain 2  score: 91.7 bits;  conditional E-value: 1.4e-30
     DUF4209   1 lErllrdlielagkktrkkkkekeklls........dlLaseelkeilgeelalilrvllgpprglNLRNvvwHGfiseeefsksllsllllllasl 89 
                 lEr+l+dl++l++kk+++++++  ++++        +lL+ ee++e+lg+e+++i+r++ gp +glNLRNv+wHGf+++e+f+++++s+l+ll++s+
  EFC39729.1 200 LERTLGDLLLLVSKKSKDNPNDLVSIIEnfrelkinELLMVEEIEEALGKEFVFIFRCFSGPLQGLNLRNVLWHGFLDSENFPRCFASFLILLIISI 296
                 7*********************88888888888899**********************************************************986 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.024
     DUF4209  44 lalilrvllgpprglNLRNvvwHGfiseeef 74 
                 +  ++ +l+  + g+ +R  + HG+++++++
  EFC39729.1 465 MLSLFDILF-FKDGPRIRDKLSHGVVDPHQI 494
                 445555555.7889999********999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (814 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       920  (0.0513135); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.49
# Mc/sec: 4985.24
//
Query:       EFC39730.1  [L=501]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.6e-12   46.7   0.0    1.4e-08   34.7   0.1    4.0  3  cNMP_binding  Cyclic nucleotide-binding domain


Domain annotation for each model (and alignments):
>> cNMP_binding  Cyclic nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.1   0.0    0.0013        24      15      33 ..     190     207 ..     174     226 .. 0.77
   2 ?   -0.1   0.0     0.055   9.9e+02      66      84 ..     269     287 ..     241     290 .. 0.74
   3 !   34.7   0.1   7.6e-13   1.4e-08       2      89 .]     330     446 ..     329     446 .. 0.83

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.0013
                   SB-SEEEEEEES-EEEEEE CS
  cNMP_binding  15 dpadslyivlsGevrvyrl 33 
                   ++++++y+vl+G+++++ +
    EFC39730.1 190 KKPQYFYVVLKGSISLT-S 207
                   4579**********995.3 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.055
                   EEESSTEEEEEEEHHHHHH CS
  cNMP_binding  66 vvAltdsellalprddfle 84 
                    vA ++s +l++p +  ++
    EFC39730.1 269 WVANEESDILRIPTEVYNN 287
                   6899********9987665 PP

  == domain 3  score: 34.7 bits;  conditional E-value: 7.6e-13
                   EEE-TT-EEE-TTSB-SEEEEEEES-EEEE...........EEETTS.EEEEEEE-TTEEESHHHHH..................HTS--SSEEEES CS
  cNMP_binding   2 rsfkagevifrqGdpadslyivlsGevrvy...........rlsedgkevvlavlgpGdlfGelall..................tgeprtatvvAl 69 
                   ++++  ++i++qG p++ +y+++sGev+v            +++e  + v l +l+++++fGe+ ll                  +  +r a++ + 
    EFC39730.1 330 QHLPSRHTIIKQGRPGNMMYFIKSGEVAVLrrlkfqdtvgvKTTEFVRFVELSRLKQKEYFGERVLLacvnenlnesktdisisnNYCSRLASIYTT 426
                   688999***********************97777666555555555577788899********999999888888888777776533458888**** PP

                   STEEEEEEEHHHHHHHHHH- CS
  cNMP_binding  70 tdsellalprddflellqqd 89 
                   t++ l++++r +f +++++d
    EFC39730.1 427 TETILYCINRTSFSNFFNKD 446
                   ***************99875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (501 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       864  (0.0481901); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 2926.18
//
Query:       EFC39731.1  [L=888]
Description: transportin 1 isoform 2-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.8e-28   98.6   3.0    9.7e-13   48.3   0.0   10.2 10  HEAT_EZ        HEAT-like repeat
    1.1e-15   56.4   9.0       0.29   11.5   0.0   10.4 10  HEAT           HEAT repeat
    2.9e-10   40.4   0.0      0.033   14.2   0.0    4.7  5  Cnd1           non-SMC mitotic condensation complex subunit 1
      5e-09   36.4   0.0    0.00084   19.7   0.0    5.7  5  HEAT_2         HEAT repeats
    1.3e-08   34.6   1.9    1.6e-07   31.1   0.1    3.2  2  IBN_N          Importin-beta N-terminal domain
    7.3e-08   32.9   0.2     0.0016   19.0   0.0    5.4  5  Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
    4.7e-06   26.3   0.0        1.3    8.6   0.0    4.4  3  CLASP_N        CLASP N terminal
    1.4e-05   24.9   2.3        4.6    7.4   0.0    6.4  7  Arm            Armadillo/beta-catenin-like repeat
    9.4e-05   21.2   0.9        1.3    7.5   0.2    3.9  4  Adaptin_N      Adaptin N terminal region
     0.0004   20.2   0.0      0.094   12.6   0.0    4.1  4  DUF3437        Domain of unknown function (DUF3437)
  ------ inclusion threshold ------
      0.043   13.6   0.0         18    5.1   0.0    3.0  2  TFCD_C         Tubulin folding cofactor D C terminal
       0.57   10.2   4.7         13    5.8   0.5    4.5  4  Xpo1           Exportin 1-like protein


Domain annotation for each model (and alignments):
>> HEAT_EZ  HEAT-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       3.2   4.7e+03      27      52 ..     126     152 ..     126     155 .. 0.64
   2 ?    4.9   0.0     0.027        40      22      49 ..     167     194 ..     149     197 .. 0.85
   3 ?    3.0   0.0      0.11   1.6e+02      30      52 ..     218     240 ..     202     242 .. 0.68
   4 ?    2.9   0.1      0.11   1.6e+02      21      37 ..     298     314 ..     290     318 .. 0.82
   5 !   48.3   0.0   6.5e-16   9.7e-13       1      54 [.     415     468 ..     415     469 .. 0.98
   6 !    6.3   0.0    0.0096        14       3      33 ..     500     530 ..     500     534 .. 0.91
   7 ?    5.4   0.0     0.018        26      10      43 ..     548     586 ..     545     601 .. 0.81
   8 !   11.0   0.0   0.00032      0.48       3      55 .]     681     733 ..     679     733 .. 0.93
   9 ?    1.1   0.0       0.4   5.9e+02      23      41 ..     742     760 ..     734     764 .. 0.86
  10 ?    2.2   0.0      0.18   2.7e+02      10      34 ..     772     796 ..     765     801 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 3.2
     HEAT_EZ  27 peilpaLlalLnddsd.eVRaaAagaL 52 
                 p+ + +Ll lL +++       +  +L
  EFC39731.1 126 PQCISQLLTLLGNSNNqQLVDGTMACL 152
                 678899999995555425465555555 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.027
     HEAT_EZ  22 lqplvpeilpaLlalLnddsdeVRaaAa 49 
                  ++++++++p L+++++ ++  +R++A+
  EFC39731.1 167 YAQQLTVLIPVLIKFMEYPNEGIRKNAL 194
                 4568999**************9999997 PP

  == domain 3  score: 3.0 bits;  conditional E-value: 0.11
     HEAT_EZ  30 lpaLlalLnddsdeVRaaAagaL 52 
                 l+ L +  nd s + R++A++a+
  EFC39731.1 218 LRSLFNIANDNSVTLRKYACRAF 240
                 444557777777788******96 PP

  == domain 4  score: 2.9 bits;  conditional E-value: 0.11
     HEAT_EZ  21 llqplvpeilpaLlalL 37 
                  lq ++p+++p Ll+ +
  EFC39731.1 298 ILQNHLPQLVPVLLSKM 314
                 6899*********9766 PP

  == domain 5  score: 48.3 bits;  conditional E-value: 6.5e-16
     HEAT_EZ   1 wrvRraAawaLGrlaggepellqplvpeilpaLlalLnddsdeVRaaAagaLgn 54 
                 w+vR++A++aLG++  g++  + +++p+++p+Lla  nd++++VR  +++ L++
  EFC39731.1 415 WPVRESAILALGAVSDGCMTGMLQHLPKLIPYLLAVINDEKPLVRNITCWSLSR 468
                 9***************************************************98 PP

  == domain 6  score: 6.3 bits;  conditional E-value: 0.0096
     HEAT_EZ   3 vRraAawaLGrlaggepellqplvpeilpaL 33 
                 v++aA +a+++l+++++ l+ p+++ il   
  EFC39731.1 500 VQEAASSAFATLEENAKTLVIPYLKPILETI 530
                 89***********************999866 PP

  == domain 7  score: 5.4 bits;  conditional E-value: 0.018
     HEAT_EZ  10 aLGrlaggepellqp..lvpeilpaLl...alLnddsde 43 
                 a+ +la   + +l++  +++ i+p+L+   + L+dd+++
  EFC39731.1 548 AIRTLADSVGSHLNKpiFIQLIIPPLItkwNNLMDDDKD 586
                 56556788888888889*************666666653 PP

  == domain 8  score: 11.0 bits;  conditional E-value: 0.00032
     HEAT_EZ   3 vRraAawaLGrlaggepellqplvpeilpaLlalLnddsdeVRaaAagaLgnl 55 
                 vR +++ ++G la ++ e+l+  +p+ lp  +a  n + ++V  +A++ +g +
  EFC39731.1 681 VRQSGLGVIGDLAKNGIEYLKNGLPQFLPIIIANINPKAQSVCNNACWSFGEI 733
                 9999*******************************86666**********986 PP

  == domain 9  score: 1.1 bits;  conditional E-value: 0.4
     HEAT_EZ  23 qplvpeilpaLlalLndds 41 
                 + + +ei p +++ Ln++s
  EFC39731.1 742 ASYATEIFPKMIPILNSPS 760
                 56889***********987 PP

  == domain 10  score: 2.2 bits;  conditional E-value: 0.18
     HEAT_EZ  10 aLGrlaggepellqplvpeilpaLl 34 
                 ++Gr+a ++p+ ++p++p+i + L+
  EFC39731.1 772 TIGRIALVCPQIVAPNLPVICKNLC 796
                 79****************9966665 PP

>> HEAT  HEAT repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.045        67       4      21 ..      93     110 ..      90     117 .. 0.86
   2 !    7.4   0.0     0.004         6       1      28 [.     174     201 ..     174     203 .. 0.92
   3 ?    3.6   0.1     0.068     1e+02       5      28 ..     221     244 ..     218     246 .. 0.83
   4 ?    2.0   0.0      0.22   3.3e+02      11      28 ..     373     390 ..     370     393 .. 0.85
   5 !   10.5   0.0   0.00042      0.63       1      31 []     401     432 ..     401     432 .. 0.83
   6 !   11.5   0.0   0.00019      0.29       1      29 [.     443     471 ..     443     473 .. 0.92
   7 ?    1.9   0.1      0.23   3.5e+02       5      27 ..     489     511 ..     485     515 .. 0.78
   8 ?    6.0   0.0     0.012        17       1      30 [.     666     695 ..     666     696 .. 0.93
   9 ?    3.0   0.0       0.1   1.5e+02       1      27 [.     707     733 ..     707     736 .. 0.90
  10 ?   -3.1   0.1       9.4   1.4e+04       2      10 ..     788     796 ..     788     796 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.045
                 HHHHHHT-SSHHHHHHHH CS
        HEAT   4 lllkllsDpspeVReaAa 21 
                 lll++l D+ p++R++A 
  EFC39731.1  93 LLLEALGDDIPFIRSTAG 110
                 589************996 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.004
                 HHHHHHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   1 llPlllkllsDpspeVReaAakaLgala 28 
                 l+P+l+k ++ p+  +R++A+ ++ ++ 
  EFC39731.1 174 LIPVLIKFMEYPNEGIRKNALSSILQFF 201
                 79********************998875 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.068
                 HHHHHT-SSHHHHHHHHHHHHHHH CS
        HEAT   5 llkllsDpspeVReaAakaLgala 28 
                 l +  +D+s   R+ A++a++ l+
  EFC39731.1 221 LFNIANDNSVTLRKYACRAFVLLL 244
                 66778**************98775 PP

  == domain 4  score: 2.0 bits;  conditional E-value: 0.22
                 -SSHHHHHHHHHHHHHHH CS
        HEAT  11 DpspeVReaAakaLgala 28 
                 D++++ R+ +a +L  l+
  EFC39731.1 373 DSDWSLRKCSATSLDLLS 390
                 9**********9997665 PP

  == domain 5  score: 10.5 bits;  conditional E-value: 0.00042
                 HHHHHHHHHT-SSHH.HHHHHHHHHHHHHHCS CS
        HEAT   1 llPlllkllsDpspe.VReaAakaLgalaevl 31 
                 llP + + ++ + p  VRe+A++aLga++ ++
  EFC39731.1 401 LLPQIEQKMNGEVPWpVRESAILALGAVSDGC 432
                 6777777777778877***********99887 PP

  == domain 6  score: 11.5 bits;  conditional E-value: 0.00019
                 HHHHHHHHHT-SSHHHHHHHHHHHHHHHH CS
        HEAT   1 llPlllkllsDpspeVReaAakaLgalae 29 
                 l+P ll  ++D+ p VR  ++++L + a+
  EFC39731.1 443 LIPYLLAVINDEKPLVRNITCWSLSRYAR 471
                 79**********************98776 PP

  == domain 7  score: 1.9 bits;  conditional E-value: 0.23
                 HHHHHT-SSHHHHHHHHHHHHHH CS
        HEAT   5 llkllsDpspeVReaAakaLgal 27 
                 +l+ + D++  V eaA  a+++l
  EFC39731.1 489 ILSKMLDNNKCVQEAASSAFATL 511
                 444445**************987 PP

  == domain 8  score: 6.0 bits;  conditional E-value: 0.012
                 HHHHHHHHHT-SSHHHHHHHHHHHHHHHHC CS
        HEAT   1 llPlllkllsDpspeVReaAakaLgalaev 30 
                 ll++l  +++D  ++VR++ +  +g+la++
  EFC39731.1 666 LLDVLFICIKDRFSDVRQSGLGVIGDLAKN 695
                 788999999******************986 PP

  == domain 9  score: 3.0 bits;  conditional E-value: 0.1
                 HHHHHHHHHT-SSHHHHHHHHHHHHHH CS
        HEAT   1 llPlllkllsDpspeVReaAakaLgal 27 
                 +lP+++ +++ ++ +V  +A++++g++
  EFC39731.1 707 FLPIIIANINPKAQSVCNNACWSFGEI 733
                 689999999889999**********99 PP

  == domain 10  score: -3.1 bits;  conditional E-value: 9.4
                 HHHHHHHHT CS
        HEAT   2 lPlllklls 10 
                 lP+++k+l+
  EFC39731.1 788 LPVICKNLC 796
                 799***996 PP

>> Cnd1  non-SMC mitotic condensation complex subunit 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.9   0.0   0.00024      0.36      26      89 ..      94     159 ..      88     202 .. 0.77
   2 ?    1.3   0.1      0.21   3.1e+02      68     117 ..     183     234 ..     166     274 .. 0.49
   3 ?    0.8   0.1      0.31   4.6e+02      16      71 ..     211     269 ..     188     315 .. 0.72
   4 !   14.2   0.0   2.2e-05     0.033       5     116 ..     420     541 ..     416     556 .. 0.76
   5 !    7.4   0.0    0.0029       4.3      21     106 ..     665     758 ..     654     794 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00024
        Cnd1  26 LrkrLkDedpyVRktaaivvakLilndmvk.ekgflselakll.eDenprVvanalaalteiseks 89 
                 L ++L D+ p +R ta  ++a ++  d ++ + + +s+l++ll + +n++ v+ + a+l+++ e +
  EFC39731.1  94 LLEALGDDIPFIRSTAGTLIAFIFFWDQIEaWPQCISQLLTLLgNSNNQQLVDGTMACLSKVCEDN 159
                 56789******************76666662666*********888889***********999885 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.21
        Cnd1  68 eDenprVvanalaalteisekse..naiynllpdiisklsdalnecsewgqi 117
                 e +n+ +++nal+++ +  + ++  +ai  ++  ++ +l +  n+ s   ++
  EFC39731.1 183 EYPNEGIRKNALSSILQFFQLDPvpTAITDNMDAYLRSLFNIANDNSVTLRK 234
                 5555555555555555555553222444455444444444433332222222 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.31
        Cnd1  16 pnlveylvepLrkrLkDedpyVRktaaivvakL..ilndmvkekg.flselaklleDen 71 
                 ++ +++++  L +  +D++ + Rk a  ++  L  i + + +    +++ + ++   ++
  EFC39731.1 211 TDNMDAYLRSLFNIANDNSVTLRKYACRAFVLLldIPHYLKQAIStVIEYMIHCTASDD 269
                 55578888888899999999999999888887744434333322246666666664444 PP

  == domain 4  score: 14.2 bits;  conditional E-value: 2.2e-05
        Cnd1   5 lairtlg......cirvpnlveylvepLrkrLkDedpyVRktaaivvakL...ilnd.mvkekg.flselaklleDenprVvanalaalteiseksena 92 
                  ai +lg      +  + + + +l++ L + ++De+p VR+ +   +++    i ++ + k  + +l+ +++ + D+n+ V++ a +a+  + e+++++
  EFC39731.1 420 SAILALGavsdgcMTGMLQHLPKLIPYLLAVINDEKPLVRNITCWSLSRYarwIVEQpLDKYFEpVLAAILSKMLDNNKCVQEAASSAFATLEENAKTL 518
                 555555544444333444556678999999*******************9999666625555557999999999*********************9999 PP

        Cnd1  93 iynllpdiisklsdalnecsewgq 116
                 ++  l+ i+  + +a  ++ +++ 
  EFC39731.1 519 VIPYLKPILETIASAF-QIYQKKN 541
                 9999999999988653.3444444 PP

  == domain 5  score: 7.4 bits;  conditional E-value: 0.0029
        Cnd1  21 ylvepLrkrLkDedpyVRktaaivvakLilndm.vkekg...flselaklleDenprVvanalaalteisek.se...naiynllpdiisklsd 106
                 +l++ L  ++kD+ + VR+  + v+  L +n++   ++g   fl  +   ++ + ++V +na  ++ ei  k ++   + + +++p++i  l++
  EFC39731.1 665 KLLDVLFICIKDRFSDVRQSGLGVIGDLAKNGIeYLKNGlpqFLPIIIANINPKAQSVCNNACWSFGEITVKiGPeiaSYATEIFPKMIPILNS 758
                 57778889********************99986233444355666777777888899***************6442334456677777776664 PP

>> HEAT_2  HEAT repeats
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.22   3.2e+02      24      57 ..      82     115 ..      52     153 .. 0.68
   2 ?    3.6   0.0      0.06        90      32      55 ..     174     197 ..     165     216 .. 0.83
   3 ?    0.5   0.0      0.56   8.3e+02       3      38 ..     220     263 ..     218     279 .. 0.57
   4 !   19.7   0.0   5.7e-07   0.00084      10      85 ..     411     506 ..     398     509 .. 0.69
   5 ?    1.5   0.0      0.27     4e+02       6      58 ..     672     733 ..     664     760 .. 0.75

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.22
      HEAT_2  24 LgrignpealpaLvellededpavRraaaeaLga 57 
                 L +i  + ++ +L+e+l d+ p +R +a + ++ 
  EFC39731.1  82 LTDIEKEHLRLLLLEALGDDIPFIRSTAGTLIAF 115
                 3366666777788889999999999888776664 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.06
      HEAT_2  32 alpaLvellededpavRraaaeaL 55 
                 ++p L++++e +++ +R++a  ++
  EFC39731.1 174 LIPVLIKFMEYPNEGIRKNALSSI 197
                 589999999999**9999998765 PP

  == domain 3  score: 0.5 bits;  conditional E-value: 0.56
      HEAT_2   3 aLlqalendpdpevrraairaLg...rignp........ealpaLve 38 
                  L +++ nd +  +r+ a+ra     +i  p        +++++++ 
  EFC39731.1 220 SLFNIA-NDNSVTLRKYACRAFVlllDI--PhylkqaisTVIEYMIH 263
                 577778.999999999999998764422..22233112233444444 PP

  == domain 4  score: 19.7 bits;  conditional E-value: 5.7e-07
      HEAT_2  10 ndpdpevrraairaLg..........rignpealpaLvellededpavRraaaeaLgaig............dpealpaLkellddddddvvReaAae 85 
                     + vr  ai aLg           ++ p+++p+L+ +++de+p vR   +++L++++            +p  +++L ++l  d++  v+eaA +
  EFC39731.1 411 GEVPWPVRESAILALGavsdgcmtgmLQHLPKLIPYLLAVINDEKPLVRNITCWSLSRYArwiveqpldkyfEPVLAAILSKML--DNNKCVQEAASS 506
                 355677**********999999887666778*************************9885444344433333355556666655..355566666655 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.27
      HEAT_2   6 qalendpdpevrraairaLg..........rignpealpaLvellededpavRraaaeaLgai 58 
                   + +d + +vr+  + ++g          + g p+ lp+++  ++ +   v  +a+++ g+i
  EFC39731.1 672 ICI-KDRFSDVRQSGLGVIGdlakngieylKNGLPQFLPIIIANINPKAQSVCNNACWSFGEI 733
                 455.89999999999999995555544422223347788888888888889999999998877 PP

>> IBN_N  Importin-beta N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.1   0.1   1.1e-10   1.6e-07       4      74 .]      34     100 ..      32     100 .. 0.92
   2 ?    0.8   0.1       0.3   4.6e+02       7      30 ..     121     143 ..     120     145 .. 0.87

  Alignments for each domain:
  == domain 1  score: 31.1 bits;  conditional E-value: 1.1e-10
                 HHHHHHC.STCHHHHHHHHHHC.TTSHHHHHHHHHHHHHHHHHHHGGSCCCHCGSXHHHHHHHHHHHHHHHHH CS
       IBN_N   4 qLkqlek.qpgflsallqilan.seselevRqlAalyLknlitkhWsdeeekqslpseekeqIrnnllnllgs 74 
                 +L+q++   ++f+++l++i+++ +e ++  Rq+A+l+Lk +++++        sl++ eke++r  ll++lg+
  EFC39731.1  34 KLQQFNDnVHDFNNYLVHIFSKcKEVDPADRQAAGLILKANLKQKLV------SLTDIEKEHLRLLLLEALGD 100
                 69*****9**************55555799***************99......****************9985 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.3
                 HHHCSTCHHHHHHHHHHCTTSHHH CS
       IBN_N   7 qlekqpgflsallqilansesele 30 
                 q e  p++ s+ll +l ns+++ +
  EFC39731.1 121 QIEAWPQCISQLLTLLGNSNNQ-Q 143
                 66778***************99.4 PP

>> Vac14_Fab1_bd  Vacuolar 14 Fab1-binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.3   0.1      0.18   2.6e+02      21      51 ..     210     240 ..     201     246 .. 0.86
   2 ?    2.4   0.1      0.16   2.4e+02      18      49 ..     247     278 ..     241     284 .. 0.87
   3 !   19.0   0.0   1.1e-06    0.0016       3      89 ..     418     505 ..     416     513 .. 0.94
   4 ?    0.5   0.0      0.63   9.4e+02      21      74 ..     700     753 ..     680     762 .. 0.77
   5 ?   -3.1   0.0       8.2   1.2e+04      55      86 ..     819     849 ..     814     854 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.3 bits;  conditional E-value: 0.18
  Vac14_Fab1_bd  21 ikeyleeivkpvlkcfsDkdsrvRyyacEsl 51 
                    i++ ++  +++++++ +D++  +R yac ++
     EFC39731.1 210 ITDNMDAYLRSLFNIANDNSVTLRKYACRAF 240
                    67788999999*****************886 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.16
  Vac14_Fab1_bd  18 ekkikeyleeivkpvlkcfsDkdsrvRyyacE 49 
                     + +k+ ++++++ +++c   +d+ +   acE
     EFC39731.1 247 PHYLKQAISTVIEYMIHCTASDDETLSLEACE 278
                    55689999*****************9999999 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 1.1e-06
  Vac14_Fab1_bd   3 rkggligLaavaialekkikeyleeivkpvlkcfsDkdsrvRyyacEslyniakvakgevlk.llneifdalvklvaDsdesvksgae 89 
                    r+ ++++L av+ +  + + ++l ++++ +l++++D+   vR  +c sl   a+ + ++ l  +++ ++ a+ + + D+++ v+++a+
     EFC39731.1 418 RESAILALGAVSDGCMTGMLQHLPKLIPYLLAVINDEKPLVRNITCWSLSRYARWIVEQPLDkYFEPVLAAILSKMLDNNKCVQEAAS 505
                    78899*************************************************9999988659*********************996 PP

  == domain 4  score: 0.5 bits;  conditional E-value: 0.63
  Vac14_Fab1_bd  21 ikeyleeivkpvlkcfsDkdsrvRyyacEslyniakvakgevlkllneifdalv 74 
                    +k+ l ++++++++ ++ k + v   ac s+  i+ ++  e+ ++ +eif  ++
     EFC39731.1 700 LKNGLPQFLPIIIANINPKAQSVCNNACWSFGEITVKIGPEIASYATEIFPKMI 753
                    566677888888888888888888888888888888888888888888887665 PP

  == domain 5  score: -3.1 bits;  conditional E-value: 8.2
  Vac14_Fab1_bd  55 akvakgevlkllneifdalvklvaDsdesvks 86 
                    +k+  + ++++++ ++d++++ ++D  +++k+
     EFC39731.1 819 IKANPSGAVQHFSFVLDTISN-CTDPSQELKN 849
                    577777889999999998876.5677777776 PP

>> CLASP_N  CLASP N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0   0.00086       1.3      72     208 ..      66     205 ..      35     223 .. 0.81
   2 !    8.4   0.0   0.00096       1.4      16     126 ..     410     516 ..     397     529 .. 0.85
   3 ?    3.2   0.0     0.037        56      48     103 ..     701     756 ..     688     761 .. 0.85

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00086
     CLASP_N  72 tgchllkelaiqlkeqldpm.veillptLlkllgdtKkiisqnan..qalaallsnasfspri.lqvlsvalqdKnvqpReysaiwLkilltrfeshks 166
                 +++++lk  ++q   +l     e+l  +Ll+ lgd    i+++a   +a+  ++ +++  p+   q+l+++ +  n+q+    +  L+ + ++    + 
  EFC39731.1  66 AAGLILKANLKQKLVSLTDIeKEHLRLLLLEALGDDIPFIRSTAGtlIAFIFFWDQIEAWPQCiSQLLTLLGNSNNQQLVDGTMACLSKVCEDNY-AQF 163
                 56667777777777775555478888899999999999999988622566778999999999989999999999999999999999999999888.555 PP

     CLASP_N 167 kleasllldliekslkkgleDanptVRetaRstfweffkvwP 208
                 + ++ + l  + ++l+k++e +n ++R++a s + +ff+  P
  EFC39731.1 164 EGDYAQQLTVLIPVLIKFMEYPNEGIRKNALSSILQFFQLDP 205
                 55666667889***************************9877 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00096
     CLASP_N  16 etelnwdaReknilklrslikgnvpedaveelleclkqlleailkalssLrttlsstgchllkelaiqlkeq.ldpmveillptLlkllgdtKkiisqn 113
                 + e  w  Re++il l     g v++ +   +l++l +l+  +l  +++    + +  c  l++ a+   eq ld++ e +l  +l  + d+ k + ++
  EFC39731.1 410 NGEVPWPVRESAILAL-----GAVSDGCMTGMLQHLPKLIPYLLAVINDEKPLVRNITCWSLSRYARWIVEQpLDKYFEPVLAAILSKMLDNNKCVQEA 503
                 6677777777777776.....66777778888888888888888888888888889999999****9999999************************** PP

     CLASP_N 114 anqalaallsnas 126
                 a+ a+a+l +na+
  EFC39731.1 504 ASSAFATLEENAK 516
                 *********9998 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.037
     CLASP_N  48 leclkqlleailkalssLrttlsstgchllkelaiqlkeqldpmveillptLlkll 103
                  ++l q+l  i+ +++    ++++++c  + e++   ++++++++  ++p ++  l
  EFC39731.1 701 KNGLPQFLPIIIANINPKAQSVCNNACWSFGEITVKIGPEIASYATEIFPKMIPIL 756
                 34455899999***************************************998765 PP

>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.4   2.1e+03       8      33 ..       4      32 ..       2      32 .. 0.82
   2 ?    1.9   0.1      0.16   2.4e+02       4      28 ..     121     144 ..     120     156 .. 0.78
   3 !    7.4   0.0    0.0031       4.6      14      34 ..     175     195 ..     169     198 .. 0.92
   4 ?   -3.3   0.0       7.6   1.1e+04      23      36 ..     227     240 ..     222     244 .. 0.76
   5 ?    2.7   0.0     0.095   1.4e+02      14      39 ..     444     469 ..     438     471 .. 0.87
   6 ?    5.3   0.0     0.014        21      14      40 ..     708     734 ..     705     735 .. 0.87
   7 ?   -3.2   0.0       6.7     1e+04      20      40 ..     755     777 ..     749     777 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.4
                HHHTTHHHHHHHHTT...TSSHHHHHHHH CS
         Arm  8 vieaGavppLvrLLs...sedeevqeeAa 33
                v +  ++++ ++LL     +++++q+e++
  EFC39731.1  4 VPNEQGLQQVMELLInsrKGSTQIQKECT 32
                66788999999999988899999999986 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.16
                 HHHHHHHTTHHHHHHHHTT.TSSHHH CS
         Arm   4 nkdavieaGavppLvrLLs.sedeev 28 
                 +++a  ++  + +L++LL  s ++++
  EFC39731.1 121 QIEAWPQC--ISQLLTLLGnSNNQQL 144
                 67777777..*********7777765 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.0031
                 HHHHHHHTTTSSHHHHHHHHH CS
         Arm  14 vppLvrLLssedeevqeeAaw 34 
                 +p+L+++++ ++e+++++A++
  EFC39731.1 175 IPVLIKFMEYPNEGIRKNALS 195
                 9******************97 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 7.6
                 TSSHHHHHHHHHHH CS
         Arm  23 sedeevqeeAawAL 36 
                 + ++++++ A++A 
  EFC39731.1 227 DNSVTLRKYACRAF 240
                 56778888899885 PP

  == domain 5  score: 2.7 bits;  conditional E-value: 0.095
                 HHHHHHHTTTSSHHHHHHHHHHHHHH CS
         Arm  14 vppLvrLLssedeevqeeAawALsNL 39 
                 +p L++ +++e++ v+   +w Ls  
  EFC39731.1 444 IPYLLAVINDEKPLVRNITCWSLSRY 469
                 8999*******************965 PP

  == domain 6  score: 5.3 bits;  conditional E-value: 0.014
                 HHHHHHHTTTSSHHHHHHHHHHHHHHT CS
         Arm  14 vppLvrLLssedeevqeeAawALsNLa 40 
                 +p+ ++ ++ + ++v+ +A+w  + ++
  EFC39731.1 708 LPIIIANINPKAQSVCNNACWSFGEIT 734
                 688888889999*********999886 PP

  == domain 7  score: -3.2 bits;  conditional E-value: 6.7
                 HTT..TSSHHHHHHHHHHHHHHT CS
         Arm  20 LLs..sedeevqeeAawALsNLa 40 
                  L+  s++ +++e+   +++ +a
  EFC39731.1 755 ILNspSTNNSLVENLSVTIGRIA 777
                 56767899999999988888775 PP

>> Adaptin_N  Adaptin N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.0    0.0031       4.6     231     320 ..     127     230 ..      48     239 .. 0.60
   2 !    7.1   0.1    0.0012       1.7     374     510 ..     124     273 ..     105     287 .. 0.66
   3 !    7.5   0.2   0.00085       1.3     100     227 ..     386     563 ..     379     632 .. 0.57
   4 ?   -1.9   0.0      0.62   9.3e+02     114     194 ..     665     753 ..     656     766 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0031
                 HHHHHHCGGCGCSSCH.HHHHHHHHCCHCCCCST.........HHHCCHHCHHHHHHSSCCTCHHHHHCHHHHHHHHX..XTTTT.TTTCCCCSXXT.T CS
   Adaptin_N 231 ellesllnllqssnna.Vlletvnlivelapkne.........livlavnaLvrllsskdenlryvaLrtllkivkke..pkavq.hldlkifllkt.d 315
                 +++ +ll+ll +snn  ++  t  ++ ++ ++n           ++ ++ +L+++++ ++e++r  aL ++l+  + +  p+a++ + d  +++l +  
  EFC39731.1 127 QCISQLLTLLGNSNNQqLVDGTMACLSKVCEDNYaqfegdyaqQLTVLIPVLIKFMEYPNEGIRKNALSSILQFFQLDpvPTAITdNMDAYLRSLFNiA 225
                 566666666664433313333444444332222223444544557788888999999999999999999988888888777888775555444443214 PP

                 SXHHH CS
   Adaptin_N 316 ddvsi 320
                  d s+
  EFC39731.1 226 NDNSV 230
                 45555 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.0012
                 HHHHHHHHHHHHHTTXXHHH.HHHHHHHHHHHHHHS.TTTSTTCHHHHCCTCCG....XXSHH..HHHHHHHHHHHTTTTXTT.......HHHHHHCTT CS
   Adaptin_N 374 daewvldvllellslsgesv.kdeivevirdliqkv.pelheeiiekLaellek....iesee..araaaiWllGeygelvsn...te.sasdllrsla 460
                  + ++++ ll ll +s++   +d  ++ + ++ + + ++  +  +++L  l+      +e+++  +r++a+  + ++ +l +    +  ++  +lrsl 
  EFC39731.1 124 AWPQCISQLLTLLGNSNNQQlVDGTMACLSKVCEDNyAQFEGDYAQQLTVLIPVlikfMEYPNegIRKNALSSILQFFQLDPVptaITdNMDAYLRSLF 222
                 566788888888888765444888888888887644144455567777777777766655555667888888777777776666674447888888888 PP

                 TTTTTSXHHHHHHHHHHHHHHHHCXGC.C.THXHHHHHHHHHHHXXSHHHH CS
   Adaptin_N 461 ekfvlesekvklqiltalvKlyltspd.ketqekliqlvlslatssdlevr 510
                 +   ++s++++ +++ a+v l +  +  k+  + +i+++ +++ s+d  + 
  EFC39731.1 223 NIANDNSVTLRKYACRAFVLLLDIPHYlKQAISTVIEYMIHCTASDDETLS 273
                 888888888888888888777766653122233555555555555555555 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.00085
                 HHHHCCC--CCCHHHHHHHHHHHHT-SSH.HHHHHHHHHHHHCCCC....CHHCCCCCHHHHHHHCTT-SSH........................... CS
   Adaptin_N 100 LrvLssirvpelaedlapaikkllkdrsp.yvrkkAalailklykk....dpdllrkqlveeikellsdkdp........................... 166
                 L  Ls++  ++++++l+p+i++ ++ + p  vr +A+la+ ++ +       + l+k l++ +   ++d++p                           
  EFC39731.1 386 LDLLSNVFGSSILPYLLPQIEQKMNGEVPwPVRESAILALGAVSDGcmtgMLQHLPK-LIPYLLAVINDEKPlvrnitcwslsryarwiveqpldkyfe 483
                 556666666666666666666666666666666666666655544433222222223.34444444455555444444444444444444444444444 PP

                 ...............HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHH......HCS-HHHHHHHHHHHCC---SSHHHH CS
   Adaptin_N 167 ...............gvvlaAvalleeikkndrlllkllpklvrrLcnll......teldpwlqvkiiklltrlarqepeer 227
                                 v+ aA +++  ++ n +    ++p+l  +L+++       +  + ++    i++l + + ++  ++
  EFC39731.1 484 pvlaailskmldnnkCVQEAASSAFATLEENAKT--LVIPYLKPILETIAsafqiyQKKNIFILYDAIRTLADSVGSHLNKP 563
                 4444444444444448888888888888545544..6666666666666555566555666666666666655555555555 PP

  == domain 4  score: -1.9 bits;  conditional E-value: 0.62
                 HHHHHHHHHHT-SSHHHHHHHHHHHHHCCCCCHHCCCCC...HHHHHHHCTT-SSHHHHHHHHHHHHHH..HCCCCCCC...HHHHHHH CS
   Adaptin_N 114 dlapaikkllkdrspyvrkkAalailklykkdpdllrkq...lveeikellsdkdpgvvlaAvalleei..kkndrlll...kllpklv 194
                 +l++ ++ ++kdr + vr++ +  i +l k+  + l++    +++ i+  ++ k ++v  +A   + ei  k  +++++   ++ pk++
  EFC39731.1 665 KLLDVLFICIKDRFSDVRQSGLGVIGDLAKNGIEYLKNGlpqFLPIIIANINPKAQSVCNNACWSFGEItvKIGPEIASyatEIFPKMI 753
                 57777888999999999999999999999996666654322258888888888888999999888888865555555444444444444 PP

>> DUF3437  Domain of unknown function (DUF3437)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.0       1.1   1.7e+03      26      55 ..      10      39 ..       4      47 .. 0.79
   2 ?    1.6   0.0      0.18   2.7e+02       4      46 ..     418     461 ..     417     473 .. 0.80
   3 ?   -3.2   0.0       5.7   8.5e+03      24      51 ..     480     508 ..     475     510 .. 0.67
   4 !   12.6   0.0   6.3e-05     0.094       2      60 ..     806     864 ..     805     879 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 1.1
     DUF3437 26 lpevleeLaraardpapirktvkktlseFk 55
                l +v+e L + ++ +++i+k+ +  l++F 
  EFC39731.1 10 LQQVMELLINSRKGSTQIQKECTLKLQQFN 39
                66788888888887779******9999997 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.18
     DUF3437   4 rhaavlglsAlvlafpydvPkwlpevleeLaraardpap.irkt 46 
                 r +a+l+l+A+   +   + ++lp+++  L +  +d++p +r+ 
  EFC39731.1 418 RESAILALGAVSDGCMTGMLQHLPKLIPYLLAVINDEKPlVRNI 461
                 5689***********************99999888888526654 PP

  == domain 3  score: -3.2 bits;  conditional E-value: 5.7
     DUF3437  24 kwlpevlee.Laraardpapirktvkktl 51 
                 k+  +vl++ L+++  +++ +++++++++
  EFC39731.1 480 KYFEPVLAAiLSKMLDNNKCVQEAASSAF 508
                 67778888845555555557888888776 PP

  == domain 4  score: 12.6 bits;  conditional E-value: 6.3e-05
     DUF3437   2 lerhaavlglsAlvlafpydvPkwlpevleeLaraardpapirktvkktlseFkrthqD 60 
                 +er  + +gl+A ++a+p    ++   vl ++++++  +++ +++  ++l+ Fk+   D
  EFC39731.1 806 IEREHGYAGLCAAIKANPSGAVQHFSFVLDTISNCTDPSQELKNEFVQILQGFKQGMGD 864
                 67888999****************************9999*************986655 PP

>> TFCD_C  Tubulin folding cofactor D C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.0     0.012        18      18      85 ..     189     255 ..     187     259 .. 0.84
   2 ?    4.9   0.0     0.014        21      63      94 ..     745     776 ..     726     787 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.012
      TFCD_C  18 vRavAgkvlqrllhndpakipsiphreel.ekifpeeeeedlnwnspsevfprlvqLLqlpeyresvle 85 
                 +R  A + ++++++ dp + +   ++++  +++f+    +d ++   + + +++v LL++p y ++ ++
  EFC39731.1 189 IRKNALSSILQFFQLDPVPTAITDNMDAYlRSLFNIA--NDNSVTLRKYACRAFVLLLDIPHYLKQAIS 255
                 7999************997566666666668899877..7888899999**************998876 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.014
      TFCD_C  63 psevfprlvqLLqlpeyresvleGlvvSvGgl 94 
                 ++e+fp+++++L+ p+ + s++e l v++G +
  EFC39731.1 745 ATEIFPKMIPILNSPSTNNSLVENLSVTIGRI 776
                 6899*************************976 PP

>> Xpo1  Exportin 1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.8   0.5    0.0088        13       3      52 ..     104     155 ..     103     240 .. 0.82
   2 ?    1.7   0.0      0.16   2.4e+02      82     145 ..     442     504 ..     433     508 .. 0.68
   3 ?   -1.5   0.0       1.5   2.3e+03      81     137 ..     610     675 ..     599     684 .. 0.72
   4 ?   -3.3   0.0       5.7   8.4e+03      26      56 ..     849     878 ..     830     882 .. 0.54

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0088
                 HHHHHHHHHHHHHHHHHTTTTSTTHHHHHHHHHCT...HHHHHHHHHHHHHH CS
        Xpo1   3 flrnklaealaelflqeypnnWpsffddllsllsss..psglelllriLkvl 52 
                 f+r+    ++a +f  +  + Wp+++++ll ll +s  ++ ++ ++  L+ +
  EFC39731.1 104 FIRSTAGTLIAFIFFWDQIEAWPQCISQLLTLLGNSnnQQLVDGTMACLSKV 155
                 7888888899999999999*************99964555566666655544 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.16
                 HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHTTTS-HHHHHTSCHHHHHHHHC.CSCCCHHHH CS
        Xpo1  82 kilelllqileqsqskkqsselveavLkclsswvswidiglivnnpllnllfqlL.sdpelreaa 145
                 k++  ll +++  +       ++  +L  +++w+ + ++++ +++ l  +l ++L ++++++eaa
  EFC39731.1 442 KLIPYLLAVINDEKPL--VRNITCWSLSRYARWIVEQPLDKYFEPVLAAILSKMLdNNKCVQEAA 504
                 4444444444444433..3566666788888999999*******999999999995555666666 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1.5
                 HHHHHHHHHHHHHHHHCC......HHHHHHHHHHHHHHHHTT..TS-HHHHHT.SCHHHHHHHHCC CS
        Xpo1  81 qkilelllqileqsqskk......qsselveavLkclsswvs..widiglivn.npllnllfqlLs 137
                 + ++  +++i+++ ++ +      +  e v  +L+ ++  ++    ++++i+  ++ll++lf  ++
  EFC39731.1 610 EPVFHRCIKIIQTIFEIDqkrpqeADREFVICSLDLIGGILEglGPNVNQILTtSKLLDVLFICIK 675
                 556666666666666666666676778888888888888888877889999996779999987774 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 5.7
                 THHHHHHHHHCT.HHHHHHHHHHHHHHHHHH CS
        Xpo1  26 sffddllsllssspsglelllriLkvlpeEi 56 
                 + f ++l+ +++++   ++ +  L+++pe+i
  EFC39731.1 849 NEFVQILQGFKQGMG-DQAWISYLTSIPEDI 878
                 344444444444332.224455566666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (888 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       549  (0.0306208); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.86u 0.35s 00:00:01.21 Elapsed: 00:00:00.53
# Mc/sec: 4999.59
//
Query:       EFC39732.1  [L=443]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.81    9.2  11.0      0.088   12.3   5.0    2.1  2  E1-E2_ATPase  E1-E2 ATPase


Domain annotation for each model (and alignments):
>> E1-E2_ATPase  E1-E2 ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   5.0   4.9e-06     0.088      94     179 ..     181     263 ..     175     265 .. 0.88
   2 ?   -0.5   0.3     0.043   7.7e+02     142     166 ..     283     304 ..     268     316 .. 0.62

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.9e-06
                   TTTTSTTS--------HHHHHHHHHHHHHHHHHHHHHHHHHHS-STTTSSTTHHHHHHHHHHHHHS-TTHHHHHHHHHHHHHHHHH CS
  E1-E2_ATPase  94 lgkiarlveeakskktplqkkldklgkvlvpvvlliallvflialllgkslaeallralallvaaiPcaLplavplalalgarrla 179
                    ++i++l+++ +skk+  + +l  l++++++ ++li+++++l  +l++     +l+   a++++ +P  L++ +++  ++  rrl+
    EFC39732.1 181 WSHIVDLIKSNQSKKKLSKYNLILLISIYIFNAFLIIIAIVLCSILKTS---VYLFALAAVAMILVPTILIVSFTTYGIVIYRRLK 263
                   579********99999999999999999999999999999999977655...589999*****************99988888875 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.043
                   SSTTHHHHHHHHHHHHHS-TTHHHH CS
  E1-E2_ATPase 142 kslaeallralallvaaiPcaLpla 166
                   +   +al+++++l+++++P  + + 
    EFC39732.1 283 N---TALFFGFVLAIIFVPTFISTW 304
                   2...567778888888888776555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (443 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1332  (0.074293); expected 358.6 (0.02)
Passed bias filter:                      375  (0.0209158); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.26s 00:00:00.92 Elapsed: 00:00:00.46
# Mc/sec: 2871.71
//
Query:       EFC39733.1  [L=223]
Description: START domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-12   47.7   0.1    1.5e-12   47.4   0.1    1.0  1  START           START domain
  ------ inclusion threshold ------
      0.058   13.6   0.2       0.53   10.5   0.2    2.0  1  Polyketide_cyc  Polyketide cyclase / dehydrase and lipid tran


Domain annotation for each model (and alignments):
>> START  START domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.4   0.1   1.7e-16   1.5e-12      19     190 ..      20     195 ..      15     212 .. 0.83

  Alignments for each domain:
  == domain 1  score: 47.4 bits;  conditional E-value: 1.7e-16
                 TT-EEEEE.CCTTEEEEEEESSS-SCEEEEEEEECCSCHHHHHHHHHCCCGGGTTCT-TT-SEEEEEEEECTT...EEEEEEEE--TT..-SS-.EEEE CS
       START  19 egWvllvdsengdevlqkveeskvksgealraigvvdmvaallveellkdaeyraqWdktlasaetvevissg...galqlyvaelvalsplsp.Rdfv 113
                  gW ++ ++e  + + +kv ++   s   ++  gvv  ++ +++e  ++++ yr   ++t  +a+ ve  +++    ++ + ++ l  ++ l++ Rdf 
  EFC39733.1  20 VGWEKDTENEHVTLYCKKVYKE--LSNPSIKFTGVVNYPLDEVFEVSRNVK-YRIHMNETTVEAKWVEEPQQDsegKSYDVFYTRLKGPNALVShRDFI 115
                 6899999999999999999773..355556666666666665555555555.99999****************99989999999999999********* PP

                 EEEEEEE..TTS-EEEEEEEE..E-TTS--.-TTSEE-EESSEEEEEEEECTCE.EEEEEEEXEEXXSSXXHHHHHHHHHH CS
       START 114 flRsire.lgdgsyvivdrSv..tseqnppesssvvRaellpSgilieplgngh.skvtwvehvdlkgwlpkwllrslvks 190
                 ++R +   +  + +    rS+  + +q ++  s+v+R+e  ++ + +e++ +g+ +k+t++ +v+++gwlp+ ++  + k+
  EFC39733.1 116 IAREWWYdEANKAWWMIMRSIpyDGPQGKE-VSGVIRGEFVIQAFKFESVNDGKaTKFTIMAQVEYGGWLPSGVIGFFQKK 195
                 *****9988899999999998445667777.7***************************************9887655555 PP

>> Polyketide_cyc  Polyketide cyclase / dehydrase and lipid transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.2   5.9e-05      0.53       2     129 ..      54     204 ..      53     205 .. 0.59

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 5.9e-05
                     SS-HHHHHHHHTTTGGCCSCCCCEEEEEE.SSSEE.......E.............................EEECSTTSSCEEEEEEEEEEETT CS
  Polyketide_cyc   2 papadqvyalvadvesypeflphcssvevleeaes....glsa.............................dlevgfggltesftarvtldppe 63 
                     ++p+d+v+++ ++v    +++   ++++++ee ++                                     +   +++++ +s   +  ++++ 
      EFC39733.1  54 NYPLDEVFEVSRNVKYRIHMNETTVEAKWVEEPQQdsegK--SydvfytrlkgpnalvshrdfiiarewwydEANKAWWMIMRSIPYDGPQGKEV 146
                     5666666666666666666666666666666666544320..13334444455555555555555555555444444444444443333333333 PP

                     T..EEECTTCCCCCEEEEEEEECTECCEEECEEEEEEEEEEEE-SSCHHHHHHHHHHHHHHHHHHHHH CS
  Polyketide_cyc  64 e..itfklvegdfkslegkWtieslppnsggtrtkvalevdfkfaspllgalvgqvaervldellaal 129
                     +  i+        +    + ++es+ +   g++tk ++  +++ +++l+  ++g++++++  ++ + l
      EFC39733.1 147 SgvIRG-------EFVIQAFKFESVND---GKATKFTIMAQVEYGGWLPSGVIGFFQKKIPLDMKDKL 204
                     322111.......22234577889998...****************************9999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (223 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       384  (0.0214178); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.32s 00:00:00.81 Elapsed: 00:00:00.47
# Mc/sec: 1422.86
//
Query:       EFC39734.1  [L=183]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        9.8    6.5  12.6        2.2    8.6   2.4    2.1  2  DUF996    Protein of unknown function (DUF996)


Domain annotation for each model (and alignments):
>> DUF996  Protein of unknown function (DUF996)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   2.4   0.00012       2.2      36      97 ..       6      69 ..       1      87 [. 0.56
   2 ?    3.7   2.8    0.0038        68      44      92 ..      89     143 ..      81     168 .. 0.55

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00012
      DUF996 36 siialvvailalllvlgalatalelpgleeaaslilllllvliiayvlliis..avflkksyel 97
                +++ lv++ l  l+++++++  l+  + ++  + i +++l+l i++++ iis  ++f  ++ye+
  EFC39734.1  6 EVVLLVFVLLSSLTTFFTSIPNLNQVDHDCSGQSIYFVILALAIVALVEIISlaTTFQLSVYEE 69
                3444444444444555555555555555555558999999998888888887213444555555 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.0038
      DUF996  44 ilalllvlgalatalelpgleeaas............lilllllvliiayvlliisavflk 92 
                 ++ l  ++++la +++++ l e+++            +++      i++++++ +sa+++ 
  EFC39734.1  89 VFSLSCWIVRLALIITSTSLIEGPAcikssiytldlhYFV------IAMWIFWAASALLII 143
                 5666666667777776666666666444443333322222......444444444444332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (183 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       875  (0.0488036); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.57u 0.29s 00:00:00.85 Elapsed: 00:00:00.51
# Mc/sec: 1080.48
//
Query:       EFC39735.1  [L=346]
Description: hypothetical protein NAEGRDRAFT_59212 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-07   31.0   6.2    4.7e-06   26.1   0.3    3.6  3  RPEL      RPEL repeat


Domain annotation for each model (and alignments):
>> RPEL  RPEL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.7   0.2    0.0029        53      15      23 ..      87      95 ..      87      95 .. 0.90
   2 !   26.1   0.3   2.6e-10   4.7e-06       1      23 [.     124     146 ..     124     146 .. 0.96
   3 !    2.2   0.0    0.0085   1.5e+02       8      17 ..     235     244 ..     233     244 .. 0.90

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.0029
        RPEL 15 LvernILpe 23
                L ernIL++
  EFC39735.1 87 LRERNILRD 95
                88*****97 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 2.6e-10
        RPEL   1 sLerKLshRPtreELvernILpe 23 
                 sL +KL++RP+ e L++r+I+p+
  EFC39735.1 124 SLSQKLENRPNIEQLEQRGIIPF 146
                 899******************96 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.0085
        RPEL   8 hRPtreELve 17 
                 +RP++ +Lv+
  EFC39735.1 235 RRPSKKDLVD 244
                 6*******95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1495  (0.0833845); expected 358.6 (0.02)
Passed bias filter:                      377  (0.0210274); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.33s 00:00:01.00 Elapsed: 00:00:00.54
# Mc/sec: 1937.57
//
Query:       EFC39736.1  [L=242]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.9e-23   80.8   0.0    1.8e-22   79.8   0.0    1.5  1  Peptidase_C97  PPPDE putative peptidase domain
  ------ inclusion threshold ------
      0.012   15.9   0.0      0.027   14.8   0.0    1.6  1  LRAT           Lecithin retinol acyltransferase
      0.058   13.8   0.1        0.1   13.0   0.1    1.4  1  SVIP           Small VCP/p97-interacting protein
       0.45   10.6   1.6       0.52   10.4   0.4    1.6  2  WLM            WLM domain


Domain annotation for each model (and alignments):
>> Peptidase_C97  PPPDE putative peptidase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   79.8   0.0     4e-26   1.8e-22       2     122 ..       8     112 ..       7     147 .. 0.81

  Alignments for each domain:
  == domain 1  score: 79.8 bits;  conditional E-value: 4e-26
                    EEEEEEEETT...TTHHHHHHHHHHSS-----EEEEEEETTEEEE--T.....T-SEEESTT-STT-.S-SEEEEEEEE---HHHHHHHHHHHHTT CS
  Peptidase_C97   2 kvelivyDlsldkkglarrvyptllGkkieGiyhtgvevygleyafggkekeegGifelkpgttsegakpresieigeTevteeevraileelsse 97 
                    ++ l+vyDl+ d++    +  +++ G    Giyh+g+++ g+ey+fg       G fe +p++  + +  r si + + e++++++ +i++e+s+e
     EFC39736.1   8 EIHLNVYDLV-DNN----N--LYVYGL---GIYHSGLQIGGTEYTFGR-----EGAFEHEPKK-APAVPLRDSIFLATIELPRDRIVSIVDEVSKE 87 
                    689*******.333....2..445788...9***************99.....9*********.8888**************************** PP

                    --GGG-BTTTB-HHHHHHHHHHHHH CS
  Peptidase_C97  98 ytgdkYnLiskNCnhFtdelvdfLt 122
                    ++ +kY+L+++NCnh++++l +++ 
     EFC39736.1  88 FNTQKYHLLNRNCNHYAKALYERII 112
                    *******************988764 PP

>> LRAT  Lecithin retinol acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.8   0.0   5.9e-06     0.027      89     120 ..      72     106 ..      45     109 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.9e-06
                 --HHHHHHHHHH...HTT-E-SCGHHCHHHHHHHH CS
        LRAT  89 lpneeviqrAee...lvGeveYsllsnNCEhFvty 120
                 lp++++++   e      +++Y+ll++NC h++  
  EFC39736.1  72 LPRDRIVSIVDEvskEFNTQKYHLLNRNCNHYAKA 106
                 4555555444443227788*************976 PP

>> SVIP  Small VCP/p97-interacting protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   2.3e-05       0.1      18      37 ..     219     238 ..     198     241 .. 0.79

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.3e-05
        SVIP  18 tpdaeerRrqqaEAAekRqe 37 
                 + +ae rR++++ AAekR  
  EFC39736.1 219 EDSAESRRERMLKAAEKRMS 238
                 45789*************75 PP

>> WLM  WLM domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0      0.77   3.4e+03      44      61 ..      86     103 ..      83     107 .. 0.84
   2 ?   10.4   0.4   0.00012      0.52     141     190 ..     162     237 ..     150     238 .. 0.75

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 0.77
         WLM  44 tElaPkeanlLGlNvnkG 61 
                  E+  ++++lL  N n+ 
  EFC39736.1  86 KEFNTQKYHLLNRNCNHY 103
                 589999999**9999995 PP

  == domain 2  score: 10.4 bits;  conditional E-value: 0.00012
         WLM 141 ksaeeeeekealekagiagkgarlGgrseekt..........................rskasareliaaAaerRl 190
                 + +e+++ ++ ++ + ++g+g+ l +r+e+k+                          +s +s+re +++Aae+R+
  EFC39736.1 162 TADEASSTGAGSKFSAFQGSGRSLSAREEPKKsssgglfnsmfskdqsqdieipayyeDSAESRRERMLKAAEKRM 237
                 3345666667777777777777887777755557788888888888888888888888*****************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (242 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       521  (0.0290591); expected 358.6 (0.02)
Passed bias filter:                      429  (0.0239277); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.33s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1432.32
//
Query:       EFC39737.1  [L=439]
Description: Hypothetical protein NAEGRDRAFT_72470 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00046   20.0   0.2     0.0022   17.9   0.0    2.3  2  F-box-like  F-box-like
     0.0043   16.9   1.1       0.02   14.8   0.1    2.7  3  F-box       F-box domain
  ------ inclusion threshold ------
       0.83    9.9   9.6         11    6.4   0.0    4.4  5  LRR_6       Leucine Rich repeat
        5.1    7.7  21.2       0.88   10.1   2.5    5.1  5  LRR_4       Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   0.0   4.8e-07    0.0022       9      46 ..      55      91 ..      52      93 .. 0.94
   2 ?   -2.3   0.0         1   4.5e+03       7      17 ..     128     138 ..     127     144 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 4.8e-07
  F-box-like  9 LlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrlv 46
                L  I s+L+ sd+ +l+lVCr  ++++++   +W++l+
  EFC39737.1 55 LALIISFLEKSDIGNLSLVCREAKQATYSS-TVWNELC 91
                6789***********************999.****998 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 1
  F-box-like   7 EiLlqIFsyLp 17 
                 + +++IF++L+
  EFC39737.1 128 DFICRIFERLN 138
                 56899**9885 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0         1   4.7e+03      31      43 ..      29      41 ..      29      44 .. 0.77
   2 !   14.8   0.1   4.5e-06      0.02      11      46 ..      55      90 ..      50      92 .. 0.84
   3 ?   -2.1   0.0      0.87   3.9e+03      10      19 ..     129     138 ..     127     140 .. 0.79

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1
                HHHHHHHTTHHHH CS
       F-box 31 kgwrilidsdrlw 43
                k++r+++++    
  EFC39737.1 29 KRVRNYCNNHPSR 41
                799****987765 PP

  == domain 2  score: 14.8 bits;  conditional E-value: 4.5e-06
                HHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHHH CS
       F-box 11 lrhILerLplsdllalrrVSkgwrilidsdrlwcks 46
                l  I+++L+ sd+ +l++V++  ++++ s   w + 
  EFC39737.1 55 LALIISFLEKSDIGNLSLVCREAKQATYSSTVWNEL 90
                778*******************99998887777665 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 0.87
                 HHHHHHHTS- CS
       F-box  10 vlrhILerLp 19 
                  ++ I+erL+
  EFC39737.1 129 FICRIFERLN 138
                 5889****97 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.1       2.8   1.2e+04       4       9 ..     172     177 ..     170     177 .. 0.85
   2 ?    2.2   0.2     0.052   2.4e+02       3      16 ..     250     264 ..     248     266 .. 0.80
   3 ?    4.7   0.1    0.0082        37       1      12 [.     274     285 ..     274     288 .. 0.87
   4 ?    6.4   0.0    0.0024        11       3      18 ..     297     312 ..     296     318 .. 0.83
   5 ?   -2.0   0.0       1.2   5.3e+03       3      13 ..     321     331 ..     320     333 .. 0.80

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 2.8
       LRR_6   4 hLteLd 9  
                 hL+ Ld
  EFC39737.1 172 HLKILD 177
                 999998 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.052
       LRR_6   3 thLteLdLsgNd.Ig 16 
                  hLt+ +Ls+   I+
  EFC39737.1 250 KHLTSISLSWTSnIS 264
                 69*******976665 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.0082
       LRR_6   1 snthLteLdLsg 12 
                 ++ +L++LdLsg
  EFC39737.1 274 KCKNLKKLDLSG 285
                 5899*******8 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.0024
       LRR_6   3 thLteLdLsgNdIgDe 18 
                 t+++ Ld+s++ ++D 
  EFC39737.1 297 TTIEVLDISSCLFDDT 312
                 799**********997 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 1.2
       LRR_6   3 thLteLdLsgN 13 
                 ++L+ ++Ls+ 
  EFC39737.1 321 PYLKFVNLSST 331
                 68999***985 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   3.6      0.28   1.3e+03      19      36 ..     164     181 ..     149     196 .. 0.57
   2 ?   -1.4   0.1      0.79   3.5e+03       8      26 ..     184     202 ..     182     203 .. 0.81
   3 ?    3.6   0.3     0.021        94      11      31 ..     238     260 ..     224     273 .. 0.68
   4 ?   10.1   2.5    0.0002      0.88       2      35 ..     251     288 ..     250     300 .. 0.72
   5 ?    4.5   0.2     0.011        50       3      40 ..     299     336 ..     297     339 .. 0.77

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.28
                 HHH-TT--EEE-.-S--- CS
       LRR_4  19 leklpnLkeLdLsgNnli 36 
                 l  l  L++L + +N+ i
  EFC39737.1 164 LDCLECLEHLKILDNSTI 181
                 223556666665566444 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.79
                 --SS---E-S-HHH-TT-- CS
       LRR_4   8 LsnNqltdiplleklpnLk 26 
                 L+nN l  i l++kl + k
  EFC39737.1 184 LFNNSLMPIRLPKKLESIK 202
                 7899999999988888776 PP

  == domain 3  score: 3.6 bits;  conditional E-value: 0.021
                 S---E-S-HHH-TT--EEE-... CS
       LRR_4  11 NqltdiplleklpnLkeLdL..s 31 
                 N ++  ++   l++L++++L  +
  EFC39737.1 238 NEIKFQSPKVDLKHLTSISLswT 260
                 45885555446********9633 PP

  == domain 4  score: 10.1 bits;  conditional E-value: 0.0002
                 S--EEE--..SS---E-S-HH....H-TT--EEE-.-S-- CS
       LRR_4   2 nLevLdLs..nNqltdiplle....klpnLkeLdLsgNnl 35 
                 +L++++Ls  + ++++ + ++    k++nLk+LdLsg ++
  EFC39737.1 251 HLTSISLSwtS-NIST-EYFNnlmgKCKNLKKLDLSGSTF 288
                 68888888876.7884.345567767*********99744 PP

  == domain 5  score: 4.5 bits;  conditional E-value: 0.011
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S-----GG CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdld 40 
                  evLd+s++   d  l  ++ lp Lk ++Ls+  li +ld
  EFC39737.1 299 IEVLDISSCLFDDTTLtmIACLPYLKFVNLSST-LI-PLD 336
                 6899999988888666766679********776.55.776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (439 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       706  (0.0393775); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.30s 00:00:00.95 Elapsed: 00:00:00.52
# Mc/sec: 2532.93
//
Query:       EFC39738.1  [L=449]
Description: hypothetical protein NAEGRDRAFT_83269 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
   1.7e-157  523.7   0.0   2.1e-157  523.4   0.0    1.1  1  Biopterin_H  Biopterin-dependent aromatic amino acid hydroxyl
  ------ inclusion threshold ------
       0.12   12.2   0.1       0.29   11.0   0.1    1.6  1  ACT          ACT domain


Domain annotation for each model (and alignments):
>> Biopterin_H  Biopterin-dependent aromatic amino acid hydroxylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  523.4   0.0  2.3e-161  2.1e-157       1     330 [.      99     436 ..      99     437 .. 0.99

  Alignments for each domain:
  == domain 1  score: 523.4 bits;  conditional E-value: 2.3e-161
  Biopterin_H   1 pwfPrkisdlDklaklvlkygaeldadhpgfkDkeyrkrrkeiadialnykhgepiprveyteeeiktWkevykklkklypthaCkeyleafklleke 98 
                  pwfP+ki+d+D++a+++l++ga l+adhpgf+D+eyr+rrk+iadialnykhg+pipr++yte+e+ktW+ +ykkl++lyp++aC++y++ f+l+e++
   EFC39738.1  99 PWFPTKIADIDHFARECLEAGAVLQADHPGFHDQEYRDRRKMIADIALNYKHGSPIPRIDYTETENKTWSIIYKKLTALYPKYACEQYNNLFPLFEQN 196
                  8************************************************************************************************* PP

  Biopterin_H  99 cgysedniPqledvskfLkektGfklRPvaGllsaRdfLaglafrvfqstqYiRhsskplytpePdvvhellGhvplladkefaqfsqeiglaslGas 196
                  cg++ed+iPql+dvs+fL ++tGf++RPv+Gll++RdfL++lafrvf+stqYiRh+skp+ytpePdvvhe+lGh+pllad++fa+fsq+iglaslGas
   EFC39738.1 197 CGFKEDKIPQLQDVSDFLLSSTGFRIRPVSGLLTSRDFLNALAFRVFHSTQYIRHHSKPYYTPEPDVVHEMLGHMPLLADSDFAEFSQQIGLASLGAS 294
                  ************************************************************************************************** PP

  Biopterin_H 197 deeieklatlywftvefglckqngelkaygaGllssygelkyalsd.......kpevkpfdpektaeqeyqiteyqpvYfvaesfedakeklrkfakt 287
                  deei++l++lyw+++efg+ k+ng+lkaygaGllss+gel+y +s        kpe+ pf pe +a++ y+it+yqp+Y+v+es+e++k+ +r+++++
   EFC39738.1 295 DEEIDRLVRLYWYCLEFGILKENGSLKAYGAGLLSSFGELEYGCSGidaetgkKPEYLPFVPEDAANRVYPITHYQPIYYVVESLESCKDLIRRYVNN 392
                  ********************************************9888888889*****************************************987 PP

  Biopterin_H 288 .lkrpfsvrydpytqsvevldskekikkllkelkeelklleeal 330
                   l+rpf+++y+pyt++v+vlds+ek+ +l+k+++++++ll+++l
   EFC39738.1 393 sLDRPFQLKYNPYTSTVDVLDSQEKLISLTKTIQNNMDLLKSSL 436
                  7***************************************9987 PP

>> ACT  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   3.2e-05      0.29      19      59 ..      34      73 ..      33      78 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 3.2e-05
                HHHHHTTSEEEEEEEEEESTTECEEEEEEEEEEHHHHHHHH CS
         ACT 19 galadrgiNidsieqrssedkvagivfvvivvdeedleevl 59
                ++++++++N+++ie+r+ +    + +++v+ vde + ++++
  EFC39738.1 34 AVFSKHNVNLIKIESRPNRF-DKKVIDFVVNVDEGVSKDIV 73
                79**************9853.36777777777777776666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (449 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       516  (0.0287802); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 2681.80
//
Query:       EFC39739.1  [L=560]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (560 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1740  (0.0970495); expected 358.6 (0.02)
Passed bias filter:                      261  (0.0145574); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.70u 0.28s 00:00:00.98 Elapsed: 00:00:00.51
# Mc/sec: 3305.92
//
Query:       EFC39740.1  [L=346]
Description: mRNA decapping protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-33  115.1   0.4    2.6e-33  114.4   0.4    1.3  1  DCP1      Dcp1-like decapping family
  ------ inclusion threshold ------
       0.16   11.9   2.8        2.2    8.2   0.1    2.4  2  DUF1825   Domain of unknown function (DUF1825)


Domain annotation for each model (and alignments):
>> DCP1  Dcp1-like decapping family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  114.4   0.4   2.9e-37   2.6e-33       1     115 [.      42     156 ..      42     158 .. 0.95

  Alignments for each domain:
  == domain 1  score: 114.4 bits;  conditional E-value: 2.9e-37
                 HHHHHHHHHHHH-TTEEEEEEEEEEEEEEEEETTTTEEEEEEEEEEEEEEEETT...S-EEEEEEESSSS--EEEEESSGGGEEEETTEEEEEETTTEE CS
        DCP1   1 rkelnlrvLqrldpsiesildtashvvlYkfnessqeWektdieGtLfvvkrske..pryglivlNrkslenliedltkelelelqgeyliyrteeeev 97 
                 r+++n+ vL+r d+ i++i +t  hvv+Ykf+  + +W+k ++eG++f+v+r++   p+y+++v+Nrks++++ +d+tk+lele++++y++yrt+ + +
  EFC39740.1  42 RQQMNIGVLKRKDKFITTIHSTFDHVVFYKFQ--DDSWDKLEVEGAMFIVERNEPkfPKYRIVVMNRKSSDDFRQDITKDLELEVHHPYVFYRTKGRII 138
                 689****************************9..689***************76445****************************************** PP

                 EEEEESSHHHHHHHHHHH CS
        DCP1  98 fgiWfyeeedreriasll 115
                  giWfy++ ++ ++ +l+
  EFC39740.1 139 KGIWFYKSLQCIEFNDLI 156
                 ***********9988765 PP

>> DUF1825  Domain of unknown function (DUF1825)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   0.1   0.00025       2.2      29      70 ..      76     117 ..      57     125 .. 0.89
   2 ?    3.5   0.3    0.0076        68       2      48 ..     268     316 ..     267     325 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00025
     DUF1825  29 kygkfdreGkkifiekleelleryrilmkrlelsddflakmt 70 
                 ++ k++ eG    +e+ e    +yri++   + sddf  ++t
  EFC39740.1  76 SWDKLEVEGAMFIVERNEPKFPKYRIVVMNRKSSDDFRQDIT 117
                 6789999********************9999******87765 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.0076
     DUF1825   2 gffdseivqqeakelfqdyqeli..qlgskygkfdreGkkifiekleel 48 
                  ff+s   qq    +  +y +++  +  +++gk     k +fi++l   
  EFC39740.1 268 HFFNSSANQQVSTVVEPEYSSVLsqECVQQFGKRKFVTKEMFINQLMFT 316
                 599999999999999999999873347899**************98655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (346 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       723  (0.0403257); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.56
# Mc/sec: 1871.87
//
Query:       EFC39741.1  [L=593]
Description: aldehyde dehydrogenase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   5.3e-130  434.0   0.1   6.7e-130  433.7   0.1    1.0  1  Aldedh    Aldehyde dehydrogenase family
  ------ inclusion threshold ------
      0.077   12.0   2.1       0.67    8.9   2.0    2.2  1  LuxC      Acyl-CoA reductase (LuxC)


Domain annotation for each model (and alignments):
>> Aldedh  Aldehyde dehydrogenase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  433.7   0.1  7.4e-134  6.7e-130       6     461 ..      63     536 ..      58     537 .. 0.93

  Alignments for each domain:
  == domain 1  score: 433.7 bits;  conditional E-value: 7.4e-134
                 SSE.EEEEETTTCEEEEE.EE-B-HHHHHHHHHHHHHHHHHHTTS-HHHHHHHHHHHHHHHHHTHHHHHHHHHHHH---HHHHHH.HHHHHHHHHHHHH CS
      Aldedh   6 set.ievinPatgeviak.vpaataedvdaavaaAkeafkawaklpaeeRaeiLrkaadlleerkeelaeletletGkplaeara.eveeaidvlryya 101
                 +++ i+++nP tge++++ vpa++++dv++ +++Ak+af++w+k+++e+R+++L  + d + ++k+e+++  +++tGk++ ea   ev  +++ +r+ +
  EFC39741.1  63 GRQmIPCTNPGTGEELCDpVPAMNTQDVEERISSAKKAFEGWSKTSFEDRKRVLLHLLDNILKHKHEIVAKSCKDTGKTMFEAHLgEVVMTCEKIRWLT 161
                 44449**********997689***************************************************************99************* PP

                 HHHHH.HSEEE..EEE.CTTEEEEEEEEE-SEEEEEE-SSSCCHHHHHHHHHHHHTT-EEEEEE-TTSHHHHHHHHH.HHHHT....TS-TTSEEE--S CS
      Aldedh 102 elaek.legev..lps.segklalvrrePlGvvgaItPWNfPlllaawklapalaaGNtvvlKPaeetplsalllae.lfeea....glPkgvlnvvtg 191
                 +  e+ l+ e+  +p     k a+v++ PlGv+g+I+PWN+P+  a+ ++++al aGN+vv+K +e +++s++ l e l+++a    g+ ++ +++++g
  EFC39741.1 162 TRGEQfLSPETrhVPLmMIYKVATVQYLPLGVIGMIVPWNYPFQNAINAIIAALFAGNSVVIKVSEWATWSSVELYEhLVQDAlikaGFSPDTVQFIVG 260
                 *****88888744555448999**************************************************777652555555555************ PP

                 STCCHHHHHHH-TTESEEEEES-HHHHHHHHHHHHCTTSEEEEEE---EEEEE-TTSHHHHHHHHHHHHHHGGGGTSTTSEEEEEEEHHHHHHHHHHHH CS
      Aldedh 192 sgsevgealvehpevdkvsftGstevgrkiakaaaknlkrvtlElGGknplivledaDldkaveaivkgafgnaGQvCiaasrllvqesiydefveklv 290
                  g e+g+al+++++  +v f+Gs e+g+k++ aa++nl++vtlElGGk+p+iv+eda++d av+ +++++++n GQ+Ciaa+rl+v+e+i+d+fv+k v
  EFC39741.1 261 FG-EAGNALAKSKNTSHVFFIGSPEIGKKVMMAATENLTPVTLELGGKDPFIVCEDANVDIAVDVAIRASLYNCGQNCIAAERLYVHEKIHDKFVAKAV 358
                 88.6*********************************************************************************************** PP

                 HHHHT--BS-TTS........TT-SB---SSHHHHHHHHHHHHHHHHTTSEEEE-TTE.SB-SSSTTEE--EEEES-TTTSHHHHS---SSEEEEEEES CS
      Aldedh 291 eaakklkvgdpld........edtdvGPliseaqlekvekyveeakeegaklllGgereeaglekgyfvePtvlanvtpdmriaqeEiFGPVlsvikfk 381
                 e +k+l++    +        e +d+G+++ + + ek+ek++++a++ gakl+lGg  +++ + kg f+ePt+l++v++dm+++q+E+FGPV++++k k
  EFC39741.1 359 ELMKSLRQRPTCTkdcalepeEINDIGAMTMSTSIEKIEKVIQDAVKGGAKLVLGG--KRNPNLKGQFLEPTLLTEVKNDMNVVQDEVFGPVVTIVKWK 455
                 *******99864445666666789********************************..678899*********************************** PP

                 SHHHHHHHHHSSSEESEEEEE-SBHHHHHHHHHHS-SSEEEESSSST--TTT.SEB--CGGGEES-BSHHHHHHHTEEEEE CS
      Aldedh 382 deeeaieiaNdteyGLaagvftkdleraervaerleaGnvyiNdsttgaaea.lpfgGvkqSglGreggkegleeytevkt 461
                 deee+i +aN+t y+L+++vf+ d +raer+ +rl aG  ++Nd+  +   + lpfgGvk Sg+Gr++g+egl+++t  k+
  EFC39741.1 456 DEEEVIGMANSTCYALGSYVFAGDQKRAERIGNRLVAGLTMVNDYGLSYLIQdLPFGGVKVSGFGRFNGPEGLRAFTIQKS 536
                 *********************************************666665569**********************98886 PP

>> LuxC  Acyl-CoA reductase (LuxC)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   2.0   7.5e-05      0.67      87     307 ..     188     403 ..      86     441 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 7.5e-05
        LuxC  87 aqprglvlhvlsgNvpll.pvmsilqglLvknvnllkvSssdpflaaallkslad...vdenhtladslsvvyfksgdtkleeeivqnaDvvvawGgee 181
                 + p g++  +++ N p   ++ +i+ +l ++n  ++kvS      +++l+  l++   +++++       +v f +  ++l+++   n   v   G+ e
  EFC39741.1 188 YLPLGVIGMIVPWNYPFQnAINAIIAALFAGNSVVIKVSEWATWSSVELYEHLVQdalIKAGFSPDTVQFIVGFGEAGNALAKSK--NTSHVFFIGSPE 284
                 5666666666666766532566777777777777777777777777777777665222223222222233566666666666654..666677777777 PP

        LuxC 182 aikaiseklkpgkq..likfGakvSfavvdkealeeealdkaaeraAkDiivfd.QqAClspqvvfvekddkieidefaeaLaaaLekrarilpkakld 277
                   k +   +  +     ++ G k  f v + +      +d a+  +A   + ++  q C+++  ++v   +ki+ + +a+a+  +L k++r  p+ ++d
  EFC39741.1 285 IGKKVMMAATENLTpvTLELGGKDPFIVCEDAN-----VDIAV-DVAIRASLYNcGQNCIAAERLYVH--EKIHDKFVAKAV--ELMKSLRQRPTCTKD 373
                 666666644444331145567777777666555.....33333.34444455663589**********..689999999999..*************** PP

        LuxC 278 edeaakisskraelklkylladekkvvssk 307
                  + +++ ++++  +++  ++++ +kv+ + 
  EFC39741.1 374 CALEPEEINDIGAMTMSTSIEKIEKVIQDA 403
                 ********************9999998654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (593 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       558  (0.0311228); expected 358.6 (0.02)
Passed bias filter:                      496  (0.0276647); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.37s 00:00:01.10 Elapsed: 00:00:00.55
# Mc/sec: 3250.00
//
Query:       EFC39742.1  [L=406]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   2.4e-146  487.5   0.2   2.8e-146  487.3   0.2    1.0  1  PGK       Phosphoglycerate kinase


Domain annotation for each model (and alignments):
>> PGK  Phosphoglycerate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  487.3   0.2  1.6e-150  2.8e-146       1     377 [.       6     393 ..       6     394 .. 0.94

  Alignments for each domain:
  == domain 1  score: 487.3 bits;  conditional E-value: 1.6e-150
                 GGGS--TT-EEEEEE-----EECTTEES--HHHHHHHHHHHHHHHTT-E.EEEEE--S--TTS-.GGG-SHHHHHHHHHHHTT-EEEESSTTSHHHHHH CS
         PGK   1 vkdldlkgkrvlvRvDfNvplkkegkitddtriraalpTikyllekgak.vvllsHlgrpkgek.eklslkpvaerLsellgkeVkfvedvvgeeveea 97 
                 ++d+d++gkrvl RvD+Nvplk+ g i+d+tri+++lpT+ky+l++ga+ vvl+sHlgrp+g+  ++++l+pva++L++llg++V+f++d+vg++ e+a
  EFC39742.1   6 IEDVDFSGKRVLARVDYNVPLKN-GIIKDNTRIKETLPTLKYILDHGASqVVLMSHLGRPDGKVvPEATLEPVAKELEKLLGEPVRFAKDCVGPDSEKA 103
                 68*******************87.**********************9988***********9766********************************99 PP

                 HHT-TTT-EEEES-GGGSTTTT.......TT-HHHHHHHHHT-SEEEE--GGGTTS--TTTTHHHHCSEEEE-HHHHHHHHHHHHHHHS--SSEEEEEE CS
         PGK  98 iaelkegevllLeNvrfykeEe.......kndeelakklasladvyVnDAFgtahrahaStvgiakvlsaaaGllmekElealskvlenperplvailG 189
                 + e k  +++lLeN+r+++eEe       ++ e+++++la+++dvyVnDAFgtahrah+S+vg++++   + G+l++kEl++++k+l +p++p+vailG
  EFC39742.1 104 VLEEK-AKIVLLENLRYHPEEEvlkgtpeEDVEKFRTQLAKYGDVYVNDAFGTAHRAHSSMVGLKRLGCCVSGYLLKKELDYFRKALVEPSKPFVAILG 201
                 99876.99*************8555544233447********************************9877***************************** PP

                 ES-HHHCHHHHHHHTTT-SEEEEETCHHHHHHHH.TT-B-TTSS--GGGHHHHHHHHHHHHHHT-EEE--SEEEEESS.S.STTS.EEEECCG--TT-E CS
         PGK 190 GakvsdkikvienLlekvdkliigGgmantFlka.qgleigkslveedklelakellekakkkgvkillpvDvvvake.e.aekeakvveveaipedem 285
                 Gakv+dkik+ien+l+kvd++ii Ggma+tF k+  g++igksl++ed ++++++llekakk+gvk+++p+D+v+a++ + +++++  ++++ ip++ m
  EFC39742.1 202 GAKVKDKIKLIENMLDKVDEMIIVGGMAFTFKKVcFGVSIGKSLFDEDGAKIVEKLLEKAKKNGVKLHFPIDHVCADAlTeTAQKSVYTDEQGIPDNLM 300
                 **********************************9*****************************************98522333356669999****** PP

                 EEEE-HHHHHHHHHHHCC-SEEEEES-SS-TTSGCCCHHHHHHHHHHHHHCH.TSEEEEESHHHHHHHHHTT-GGGSSEEESSSHHHHHHHCT CS
         PGK 286 alDigpktielfaeaikeaktvvwnGpmGvfeiekfakGTkaiakalaeatk.galsivGGgdsaaaveklgladkvshvStGGgAsLelLeg 377
                 +lDigpk++elf+e+i +akt vwnGp+Gvfei++f++G+  +++a+a at+ g++si+GGgd+++ v++ + ++kvsh+StGGgAsLelLeg
  EFC39742.1 301 GLDIGPKSVELFREVILNAKTLVWNGPAGVFEIKQFSAGSIGLLDAVATATEqGLVSIIGGGDTVSLVQNNNAQNKVSHISTGGGASLELLEG 393
                 *************************************************9999***************************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (406 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       671  (0.0374254); expected 358.6 (0.02)
Passed bias filter:                      605  (0.0337442); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.35s 00:00:01.03 Elapsed: 00:00:00.54
# Mc/sec: 2251.65
//
Query:       EFC39743.1  [L=612]
Description: leucine-rich repeat domain protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      1e-12   48.1  47.6    4.8e-05   23.6   1.0    9.8 12  LRR_4       Leucine Rich repeats (2 copies)
    8.4e-09   35.1  40.3     0.0039   16.9   0.1    7.9  9  LRR_8       Leucine rich repeat
    1.7e-07   30.7  24.9      0.047   13.8   0.4    9.7 11  LRR_6       Leucine Rich repeat
    5.1e-06   26.1  12.3    0.00042   19.9   3.0    3.7  3  LRR_9       Leucine-rich repeat
  ------ inclusion threshold ------
      0.027   14.3   0.1       0.07   13.0   0.1    1.7  1  F-box-like  F-box-like
      0.086   13.4  22.0         11    7.0   0.1    9.5 10  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.2      0.12   3.5e+02      10      30 ..     113     131 ..     106     137 .. 0.71
   2 ?    3.4   0.2     0.038   1.1e+02       2      30 ..     125     154 ..     125     164 .. 0.70
   3 !    7.6   0.1    0.0018       5.3       1      33 [.     147     181 ..     147     188 .. 0.75
   4 !    6.6   0.1    0.0036        11      13      39 ..     235     254 ..     221     272 .. 0.61
   5 ?   -0.5   0.0      0.62   1.9e+03      19      35 ..     328     344 ..     307     355 .. 0.63
   6 !    5.7   0.8    0.0069        21      18      36 ..     350     367 ..     333     377 .. 0.69
   7 !   12.8   2.6   4.1e-05      0.12       1      40 [.     355     392 ..     355     398 .. 0.82
   8 !   22.1   0.3   5.1e-08   0.00015       1      44 []     379     423 ..     379     423 .. 0.93
   9 !   23.6   1.0   1.6e-08   4.8e-05       2      36 ..     404     437 ..     403     444 .. 0.94
  10 !    7.3   7.0    0.0023       6.8       1      42 [.     425     468 ..     425     471 .. 0.79
  11 ?    1.4   7.4      0.16   4.7e+02       1      32 [.     450     480 ..     450     512 .. 0.86
  12 !   14.0   0.1   1.7e-05      0.05       1      39 [.     546     588 ..     546     593 .. 0.77

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.12
                 SS---.E-S-HHH-TT--EEE- CS
       LRR_4  10 nNqlt.diplleklpnLkeLdL 30 
                 +  ++ d+++   l nL++L+L
  EFC39743.1 113 G--ISkDFDFSL-LYNLEKLSL 131
                 4..666777766.999999999 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.038
                 S--EEE--...SS---E-S-HHH-TT--EEE- CS
       LRR_4   2 nLevLdLs...nNqltdiplleklpnLkeLdL 30 
                 nLe+L+L+   ++++ d  +++ lp+Lk+L L
  EFC39743.1 125 NLEKLSLRsqgHTMVPD--SIQCLPKLKSLQL 154
                 79999999543355554..6667999999987 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0018
                 SS--EEE--SS---E-S-HH...H-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdiplle...klpnLkeLdLsgN 33 
                 p+L++L L+   + +   +e   klp+L+eL++ +N
  EFC39743.1 147 PKLKSLQLFK-FIITATHIEswtKLPKLEELSVKHN 181
                 7899999997.3444555444557*********888 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0036
                 --E-S-HHH-TT--EEE-.-S-----G CS
       LRR_4  13 ltdiplleklpnLkeLdLsgNnlitdl 39 
                 ++ +++   lp+L+ L Ls +    d+
  EFC39743.1 235 ISIVEP---LPKLTFLKLSYC----DI 254
                 555555...666666666655....33 PP

  == domain 5  score: -0.5 bits;  conditional E-value: 0.62
                 HH.H-TT--EEE-.-S-- CS
       LRR_4  19 le.klpnLkeLdLsgNnl 35 
                 ++ k+  Lk L++  N++
  EFC39743.1 328 FNpKFSALKRLSV-PNSF 344
                 3356899999998.4433 PP

  == domain 6  score: 5.7 bits;  conditional E-value: 0.0069
                 -HHH-TT--EEE-.-S--- CS
       LRR_4  18 lleklpnLkeLdLsgNnli 36 
                  ++ ++nL+eL++++  +i
  EFC39743.1 350 DFSMFKNLTELNVNET-KI 367
                 3567*********665.54 PP

  == domain 7  score: 12.8 bits;  conditional E-value: 4.1e-05
                 SS--EEE--SS---E-S-HH..H-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdiplle..klpnLkeLdLsgNnlitdld 40 
                 +nL++L+ + +++    ll+  k+++L++L++  N    d++
  EFC39743.1 355 KNLTELNVNETKIGNKVLLAisKMTQLTSLNIGKN----DIT 392
                 79************544444548*********889....775 PP

  == domain 8  score: 22.1 bits;  conditional E-value: 5.1e-08
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGGXX CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeLkn 44 
                 ++L++L+++ N +t+  +  l+kl+nL+ LdL ++  ++d+++L++
  EFC39743.1 379 TQLTSLNIGKNDITKNVFkhLKKLDNLTALDLEDC-GVKDITPLAK 423
                 68*************99999999*********999.******9975 PP

  == domain 9  score: 23.6 bits;  conditional E-value: 1.6e-08
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnli 36 
                 nL+ LdL ++ ++di +l+kl++ ++L+L  Nn++
  EFC39743.1 404 NLTALDLEDCGVKDITPLAKLTKITKLNL-KNNYL 437
                 9****************************.88898 PP

  == domain 10  score: 7.3 bits;  conditional E-value: 0.0023
                 SS--EEE--SS---.E-S-HH...H.-TT--EEE-.-S-----GGGG CS
       LRR_4   1 pnLevLdLsnNqlt.diplle...k.lpnLkeLdLsgNnlitdldeL 42 
                 ++ ++L+L nN l+ +  +l+   + lpnL++L+ s+ n +t+l +L
  EFC39743.1 425 TKITKLNLKNNYLKgE--WLQklvSyLPNLRKLN-SEGNELTSLAPL 468
                 6889**********55..76666666*******9.454588888776 PP

  == domain 11  score: 1.4 bits;  conditional E-value: 0.16
                 SS--EEE--SS---E-S-HHH-TT--EEE-.- CS
       LRR_4   1 pnLevLdLsnNqltdiplleklpnLkeLdLsg 32 
                 pnL++L+  +N lt++ +l+ l+n ++L L  
  EFC39743.1 450 PNLRKLNSEGNELTSLAPLSLLTNIQKLKL-K 480
                 7899999889********999***999999.3 PP

  == domain 12  score: 14.0 bits;  conditional E-value: 1.7e-05
                 SS--EEE--SS---E-S-...HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl...lek.lpnLkeLdLsgNnlitdl 39 
                 ++L++LdL+ N+lt+ +     ++ lp ++++++s+N +  ++
  EFC39743.1 546 TSLRTLDLQKNNLTEKGVniiSKSyLPFMQKVNVSENKYYASI 588
                 79********9***54445643366*********999665555 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.3   3.4e-05       0.1      15      56 ..     113     154 ..     105     156 .. 0.80
   2 !   16.9   0.1   1.3e-06    0.0039       2      60 ..     125     182 ..     124     182 .. 0.94
   3 !    5.0   0.0    0.0071        21      19      35 ..     165     181 ..     156     201 .. 0.59
   4 ?    4.1   0.1     0.013        39      32      61 .]     230     254 ..     220     254 .. 0.78
   5 !   11.4   1.1   6.9e-05      0.21       3      61 .]     335     391 ..     333     391 .. 0.83
   6 !   15.0   3.1   5.3e-06     0.016       2      59 ..     356     413 ..     355     415 .. 0.91
   7 !   10.8   4.0   0.00011      0.32       2      61 .]     404     462 ..     403     462 .. 0.88
   8 !    5.8   4.9    0.0038        11       1      55 [.     450     502 ..     450     502 .. 0.96
   9 !    6.4   0.3    0.0025       7.5      25      39 ..     546     560 ..     525     583 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.4e-05
                 EE-TTSSTT.-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8  15 slddeaFkg.lsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 ++++++ ++ l nL+ L+L++   +t+ p+++++Lp+L+sL L
  EFC39743.1 113 GISKDFDFSlLYNLEKLSLRSQ-GHTMVPDSIQCLPKLKSLQL 154
                 55555544449********997.78888*************99 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 1.3e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                 nL++L+L++   t ++d+    l++Lk+L+L    +t  + +++  Lp+L++L + +N+
  EFC39743.1 125 NLEKLSLRSQGHTMVPDSIQC-LPKLKSLQLFKFIITATHIESWTKLPKLEELSVKHNP 182
                 899**********99988766.**************99999****************95 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0071
                 TSSTT-TT--EEE--SS CS
       LRR_8  19 eaFkglsnLkvLdLsnN 35 
                 e+ ++l++L++L+ ++N
  EFC39743.1 165 ESWTKLPKLEELSVKHN 181
                 44444555555555555 PP

  == domain 4  score: 4.1 bits;  conditional E-value: 0.013
                 --SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  32 LsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 Ls+ +++ +     + Lp+L++L Ls++++
  EFC39743.1 230 LSHGSISIV-----EPLPKLTFLKLSYCDI 254
                 555555555.....48***********987 PP

  == domain 5  score: 11.4 bits;  conditional E-value: 6.9e-05
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 L++L++ n+ + + +d + +  +nL++L+ ++ ++      a+s +++L+sL++  N++
  EFC39743.1 335 LKRLSVPNSFIGNRNDFSMF--KNLTELNVNETKIGNKVLLAISKMTQLTSLNIGKNDI 391
                 66666666666666665555..9**************999*****************97 PP

  == domain 6  score: 15.0 bits;  conditional E-value: 5.3e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 nLt+L+++ +++ +    a +++++L++L+++ N +t    + +  L +L+ LdL+++
  EFC39743.1 356 NLTELNVNETKIGNKVLLAISKMTQLTSLNIGKNDITKNVFKHLKKLDNLTALDLEDC 413
                 8999999999999999999****************99977799999999999999976 PP

  == domain 7  score: 10.8 bits;  conditional E-value: 0.00011
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 nLt LdL +   +++ + a  +l++ + L+L+nN l+    ++  s Lp+Lr+L+ +gN L
  EFC39743.1 404 NLTALDLEDCGVKDITPLA--KLTKITKLNLKNNYLKGeWLQKLVSYLPNLRKLNSEGNEL 462
                 7999999999999998855..679**********99999668*************999976 PP

  == domain 8  score: 5.8 bits;  conditional E-value: 0.0038
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLd 55 
                 pnL++L+   N ltsl + +    +n + L+L++ + + + +  +++L +L++Ld
  EFC39743.1 450 PNLRKLNSEGNELTSLAPLSLL--TNIQKLKLKSLKFSDIKEMQLQHLLKLEYLD 502
                 79****************9998..8****************************97 PP

  == domain 9  score: 6.4 bits;  conditional E-value: 0.0025
                 TT--EEE--SS---G CS
       LRR_8  25 snLkvLdLsnNlltt 39 
                 ++L++LdL  N+lt 
  EFC39743.1 546 TSLRTLDLQKNNLTE 560
                 566666666666664 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0         4   1.2e+04       3      10 ..     147     154 ..     146     155 .. 0.84
   2 ?    1.6   0.0      0.12   3.7e+02       3      13 ..     171     181 ..     169     182 .. 0.88
   3 !    7.3   0.0    0.0018       5.5       3      23 ..     242     262 ..     240     262 .. 0.88
   4 ?   -3.5   0.0       5.3   1.6e+04       2      10 ..     308     316 ..     307     318 .. 0.79
   5 ?    3.8   0.1     0.024        72       4      18 ..     356     370 ..     355     376 .. 0.85
   6 !    7.2   0.2     0.002       5.9       3      16 ..     379     392 ..     377     394 .. 0.89
   7 ?    4.8   0.1     0.012        36       4      17 ..     404     417 ..     401     418 .. 0.92
   8 ?    1.5   0.1      0.13   3.9e+02       3      13 ..     425     435 ..     423     440 .. 0.81
   9 ?   -2.9   0.0       3.4     1e+04       7      16 ..     476     485 ..     472     486 .. 0.48
  10 ?   -1.9   0.0       1.6   4.8e+03       7      21 ..     503     517 ..     497     517 .. 0.76
  11 !   13.8   0.4   1.6e-05     0.047       1      20 [.     544     563 ..     544     563 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4
       LRR_6   3 thLteLdL 10 
                 ++L++L+L
  EFC39743.1 147 PKLKSLQL 154
                 68****98 PP

  == domain 2  score: 1.6 bits;  conditional E-value: 0.12
       LRR_6   3 thLteLdLsgN 13 
                 ++L+eL++++N
  EFC39743.1 171 PKLEELSVKHN 181
                 79********9 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0018
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++Lt L Ls++dI  + a+++
  EFC39743.1 242 PKLTFLKLSYCDIKKVDAICI 262
                 78***********99888775 PP

  == domain 4  score: -3.5 bits;  conditional E-value: 5.3
       LRR_6   2 nthLteLdL 10 
                 +th++ L+L
  EFC39743.1 308 STHIEDLEL 316
                 789999988 PP

  == domain 5  score: 3.8 bits;  conditional E-value: 0.024
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +LteL+++  +Ig++
  EFC39743.1 356 NLTELNVNETKIGNK 370
                 7************97 PP

  == domain 6  score: 7.2 bits;  conditional E-value: 0.002
       LRR_6   3 thLteLdLsgNdIg 16 
                 t Lt+L++  NdI+
  EFC39743.1 379 TQLTSLNIGKNDIT 392
                 78***********8 PP

  == domain 7  score: 4.8 bits;  conditional E-value: 0.012
       LRR_6   4 hLteLdLsgNdIgD 17 
                 +Lt+LdL ++++ D
  EFC39743.1 404 NLTALDLEDCGVKD 417
                 79********9988 PP

  == domain 8  score: 1.5 bits;  conditional E-value: 0.13
       LRR_6   3 thLteLdLsgN 13 
                 t++t+L+L+ N
  EFC39743.1 425 TKITKLNLKNN 435
                 899******99 PP

  == domain 9  score: -2.9 bits;  conditional E-value: 3.4
       LRR_6   7 eLdLsgNdIg 16 
                 +L L++ +++
  EFC39743.1 476 KLKLKSLKFS 485
                 5555544444 PP

  == domain 10  score: -1.9 bits;  conditional E-value: 1.6
       LRR_6   7 eLdLsgNdIgDeGae 21 
                 +L++++ dIg eGa+
  EFC39743.1 503 KLSITSMDIGEEGAK 517
                 677787799999986 PP

  == domain 11  score: 13.8 bits;  conditional E-value: 1.6e-05
       LRR_6   1 snthLteLdLsgNdIgDeGa 20 
                 +nt+L++LdL+ N+++ +G+
  EFC39743.1 544 TNTSLRTLDLQKNNLTEKGV 563
                 59**************9886 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.5   0.1   0.00022      0.66      48     125 ..     108     183 ..     102     208 .. 0.83
   2 ?    0.4   0.5      0.13   3.9e+02      62     127 ..     331     393 ..     306     401 .. 0.65
   3 !   19.9   3.0   1.4e-07   0.00042      41     123 ..     402     485 ..     390     509 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00022
       LRR_9  48 dlsdndirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 dls + i k  +f ll  l+ l+l +   + + + + ++lP+l++l l +  ++  ++++  ++l+kle ls+ +np 
  EFC39743.1 108 DLSLEGISKDFDFSLLYNLEKLSLRSQGHTMVPDSI-QCLPKLKSLQLFKFIIT-ATHIESWTKLPKLEELSVKHNPE 183
                 667777888888999999*****9999888776665.89*********998776.5789**************99984 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.13
       LRR_9  62 llkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                  +  lk l++ n  i + ++    +  nl+el +++ ++ + + l  + ++ +l++l + kn +t+
  EFC39743.1 331 KFSALKRLSVPNSFIGNRND--FSMFKNLTELNVNETKIGNKV-LLAISKMTQLTSLNIGKNDITK 393
                 45566666666666654433..346677888888888887755.4567777777777777777765 PP

  == domain 3  score: 19.9 bits;  conditional E-value: 1.4e-07
       LRR_9  41 ldqfdtidlsdndirkldgfPllkrlktlllnnnriv.riaegleevlPnleelvltnnelqeladldPlaslkklellsllkn 123
                 ld + ++dl d  ++++  +  l ++  l l+nn +     ++l  +lPnl++l   +nel++la l  l++++kl+l sl  +
  EFC39743.1 402 LDNLTALDLEDCGVKDITPLAKLTKITKLNLKNNYLKgEWLQKLVSYLPNLRKLNSEGNELTSLAPLSLLTNIQKLKLKSLKFS 485
                 89999*****************************997356789999*************9999999999999999988877544 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   2.3e-05      0.07       7      41 ..      47      82 ..      45      88 .. 0.86

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 2.3e-05
  F-box-like  7 EiLlqIFsyLppsdLlr.lalVCrrWrrvaldtplL 41
                ++L  IF++L+ s L+r ++ VC +W+++ ++ p L
  EFC39743.1 47 DVLGVIFDFLDYSFLSRkCRFVCLQWNEAFCNMPVL 82
                57888***********************98777766 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1      0.51   1.5e+03       1      19 [.     125     142 ..     125     153 .. 0.75
   2 ?    0.7   0.0      0.44   1.3e+03       1      12 [.     172     183 ..     172     196 .. 0.83
   3 ?    1.1   0.0      0.33   9.8e+02       1      13 [.     243     260 ..     243     270 .. 0.77
   4 ?   -3.3   0.0         6   1.8e+04       2      12 ..     335     345 ..     334     351 .. 0.69
   5 ?   -1.7   0.1       2.6   7.8e+03       1       8 [.     356     363 ..     356     375 .. 0.82
   6 ?    3.4   0.1     0.057   1.7e+02       1      20 [.     380     399 ..     380     402 .. 0.71
   7 ?    2.6   0.0       0.1   3.1e+02       1      12 [.     404     415 ..     404     422 .. 0.81
   8 ?    1.2   0.0      0.29   8.8e+02       2      12 ..     427     437 ..     426     450 .. 0.73
   9 ?    1.6   0.6      0.22   6.7e+02       1      20 [.     451     470 ..     451     477 .. 0.85
  10 ?    7.0   0.1    0.0036        11       1      21 [.     547     567 ..     547     569 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.51
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 nL++L L+++      p+s
  EFC39743.1 125 NLEKLSLRSQGH-TMVPDS 142
                 8******99876.344444 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.44
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L++L + +np 
  EFC39743.1 172 KLEELSVKHNPE 183
                 7*********95 PP

  == domain 3  score: 1.1 bits;  conditional E-value: 0.33
       LRR_1   1 nLrhLdLsnnpl.....l 13 
                 +L+ L Ls++ +     +
  EFC39743.1 243 KLTFLKLSYCDIkkvdaI 260
                 7999******98555554 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 6
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L + n ++
  EFC39743.1 335 LKRLSVPNSFI 345
                 78888766554 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 2.6
       LRR_1   1 nLrhLdLs 8  
                 nL++L+++
  EFC39743.1 356 NLTELNVN 363
                 89****86 PP

  == domain 6  score: 3.4 bits;  conditional E-value: 0.057
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L+++ n ++     ++
  EFC39743.1 380 QLTSLNIGKNDITKNVFKHL 399
                 599********864444444 PP

  == domain 7  score: 2.6 bits;  conditional E-value: 0.1
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL+ LdL+++  
  EFC39743.1 404 NLTALDLEDCGV 415
                 89********75 PP

  == domain 8  score: 1.2 bits;  conditional E-value: 0.29
       LRR_1   2 LrhLdLsnnpl 12 
                  ++L+L nn l
  EFC39743.1 427 ITKLNLKNNYL 437
                 689******98 PP

  == domain 9  score: 1.6 bits;  conditional E-value: 0.22
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 nLr+L+ ++n l++l p s+
  EFC39743.1 451 NLRKLNSEGNELTSLAPLSL 470
                 8**********988877665 PP

  == domain 10  score: 7.0 bits;  conditional E-value: 0.0036
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +Lr+LdL  n+l+ ++ n ++
  EFC39743.1 547 SLRTLDLQKNNLTEKGVNIIS 567
                 69**********988888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (612 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       547  (0.0305092); expected 358.6 (0.02)
Passed bias filter:                      326  (0.0181828); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 3544.90
//
Query:       EFC39744.1  [L=435]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.045   14.3   0.0      0.045   14.3   0.0    2.8  4  DUF3899   Domain of unknown function (DUF3899)


Domain annotation for each model (and alignments):
>> DUF3899  Domain of unknown function (DUF3899)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0      0.55   9.9e+03      44      57 ..      56      71 ..      42     100 .. 0.52
   2 ?   -3.4   0.1       0.8   1.4e+04      35      55 ..     151     171 ..     150     187 .. 0.48
   3 ?   -1.9   0.1      0.27   4.9e+03      40      54 ..     257     274 ..     247     288 .. 0.60
   4 ?   14.3   0.0   2.5e-06     0.045      44      83 ..     394     435 .]     368     435 .] 0.76

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.55
     DUF3899 44 skkddsyyeykek..k 57
                 k ++ yy+y ++  +
  EFC39744.1 56 MKVVRYYYNYYKPtpQ 71
                4566666666665331 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 0.8
     DUF3899  35 klkklflkkskkddsyyeyke 55 
                 +++++f+++++k+  ++e k 
  EFC39744.1 151 RIREYFINRRNKKLALEETKP 171
                 566666655444444444333 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.27
     DUF3899  40 flkk...skkddsyyeyk 54 
                 +++k   +k+ ++y e +
  EFC39744.1 257 IWRKiftNKEFEKYKESN 274
                 444444366666666554 PP

  == domain 4  score: 14.3 bits;  conditional E-value: 2.5e-06
     DUF3899  44 skkddsyyeykek..kkesskkstrplliiGlllivlsivll 83 
                  kk+d+y+++ ++  kk++s  ++r  +i+G l +++s ++l
  EFC39744.1 394 HKKEDDYIQESKEqeKKNHSPLWMRSAVIAGALGLAVSSIIL 435
                 455566655555546777799****************98875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (435 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       734  (0.0409393); expected 358.6 (0.02)
Passed bias filter:                      318  (0.0177366); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.51
# Mc/sec: 2561.76
//
Query:       EFC39745.1  [L=463]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.4e-22   79.0   0.0    6.5e-22   77.6   0.0    1.8  2  Acyltransferase  Acyltransferase


Domain annotation for each model (and alignments):
>> Acyltransferase  Acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.6   0.0   3.6e-26   6.5e-22       3     134 ..      28     173 ..      26     174 .. 0.90
   2 ?   -3.7   0.0      0.48   8.6e+03      66      81 ..     191     206 ..     188     221 .. 0.67

  Alignments for each domain:
  == domain 1  score: 77.6 bits;  conditional E-value: 3.6e-26
  Acyltransferase   3 rvtglenlpekgpailvaNHqsy.lDvlllwlllyksngprnvviiakkellsipllgflmrllgfifidR...........ksnaraagslen 84 
                        +g en+p+++p+i+v NH    +D+l+l   +  sn  r ++ +ak+el+++p++gf+m+llg+i+i R           + + +  ++++ 
       EFC39745.1  28 SARGTENIPKDRPVIFVVNHYNGlVDALFLYSEV--SN--RLIRGVAKQELFNLPVVGFFMKLLGIIPIIRpcdvngkdleeQRKLSNLAAINA 117
                      56789***************9998*******977..55..89**********************************888765555555556666 PP

  Acyltransferase  85 iselleegklvviFPEGtrsregellpfkkGlvrlaakak......kgvpivPvai 134
                      ++e+l  g  +viFPEGt  +++ +l+ k+G++r+a  +       +++++vPv++
       EFC39745.1 118 MAEVLIDGHCIVIFPEGTSHNNSDILTIKTGFARAAFTCLekcenlDKIYLVPVGL 173
                      6679999********************************999***********985 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 0.48
  Acyltransferase  66 gfifidRksnaraags 81 
                      + i+idR++ +++++ 
       EFC39745.1 191 KEIPIDRNDLQEYQQD 206
                      5699999666666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (463 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       690  (0.0384851); expected 358.6 (0.02)
Passed bias filter:                      444  (0.0247643); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 2636.18
//
Query:       EFC39746.1  [L=716]
Description: transcription initiation factor TFIID subunit [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.6e-50  167.9  15.4    2.8e-10   40.6   0.1    6.7  6  WD40         WD domain, G-beta repeat
      1e-37  129.2   5.9    2.2e-37  128.2   5.9    1.6  1  TFIID_NTD2   WD40 associated region in TFIID subunit, NTD2 do
      4e-14   52.7   0.2     0.0073   16.6   0.0    4.9  5  ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
    6.1e-06   25.2   4.4      0.021   13.5   0.0    3.7  3  Nup160       Nucleoporin Nup120/160
    0.00017   20.7   0.1        6.9    5.5   0.0    4.1  4  Ge1_WD40     WD40 region of Ge1, enhancer of mRNA-decapping p
     0.0099   15.8   0.1      0.024   14.6   0.1    1.7  1  LisH         LisH
  ------ inclusion threshold ------
      0.011   15.1   0.0          6    6.1   0.0    3.4  4  WD40_like    WD40-like domain
        3.3    7.4  13.6      0.025   14.3   4.5    2.0  2  Cwf_Cwc_15   Cwf15/Cwc15 cell cycle control protein
        5.7    5.4  15.6      0.023   13.3   6.7    1.4  2  TFIIF_alpha  Transcription initiation factor IIF, alpha subun


Domain annotation for each model (and alignments):
>> WD40  WD domain, G-beta repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.0    0.0019       3.8      20      38 .]     391     409 ..     363     409 .. 0.85
   2 !   36.7   0.1   2.5e-12     5e-09       6      38 .]     444     477 ..     438     477 .. 0.90
   3 !   21.9   0.1   1.2e-07   0.00023       4      37 ..     484     518 ..     481     519 .. 0.89
   4 !   40.6   0.1   1.4e-13   2.8e-10       3      38 .]     525     561 ..     523     561 .. 0.96
   5 !   35.9   0.3   4.3e-12   8.5e-09       1      38 []     565     603 ..     565     603 .. 0.97
   6 !   30.4   0.2   2.3e-10   4.6e-07       5      38 .]     611     645 ..     607     645 .. 0.92

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0019
                 TTSSEEEEEETTSEEEEEE CS
        WD40  20 pdgawlasGsdDgtvriWd 38 
                 ++g+ +a+G  D t++ W+
  EFC39746.1 391 RNGPVIAAGFADSTIKCWN 409
                 577789***89*******8 PP

  == domain 2  score: 36.7 bits;  conditional E-value: 2.5e-12
                 EEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   6 tltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 tl GH ++v+sl+f++d++wl+s+s+D+tvr+W+
  EFC39746.1 444 TLIGHsGPVYSLSFNSDQQWLLSSSEDCTVRLWN 477
                 589**777*************************8 PP

  == domain 3  score: 21.9 bits;  conditional E-value: 1.2e-07
                 EEEEESSSS.EEEEEEETTSSEEEEEETTSEEEEE CS
        WD40   4 lrtltGHss.vtslafspdgawlasGsdDgtvriW 37 
                 + +++GH+  v+ ++fsp   ++a++s D+t r+W
  EFC39746.1 484 VVVYKGHQYaVWNVSFSPTDYMFATASHDRTARLW 518
                 5689***446**************9999******* PP

  == domain 4  score: 40.6 bits;  conditional E-value: 1.4e-13
                 EEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   3 clrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 ++r++ GH  +v +++f+p+ +++a+Gs D+tvr+Wd
  EFC39746.1 525 PVRVFAGHlADVECVKFHPNCNYVATGSSDKTVRLWD 561
                 799************************99*******9 PP

  == domain 5  score: 35.9 bits;  conditional E-value: 4.3e-12
                 TEEEEEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   1 gqclrtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 g+c+r + GH +s++ lafs+dg++ as++dDg v +Wd
  EFC39746.1 565 GECMRMFIGHhGSINTLAFSHDGRYCASAGDDGQVLVWD 603
                 68********999**************99*********9 PP

  == domain 6  score: 30.4 bits;  conditional E-value: 2.3e-10
                 EEEESS.SSEEEEEEETTSSEEEEEETTSEEEEEE CS
        WD40   5 rtltGH.ssvtslafspdgawlasGsdDgtvriWd 38 
                 +++ GH ++v+sl+f+++ ++las+s D tvr+W+
  EFC39746.1 611 YKFIGHtKPVWSLDFNRNDTFLASASLDSTVRVWS 645
                 6789**999*************************5 PP

>> TFIID_NTD2  WD40 associated region in TFIID subunit, NTD2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  128.2   5.9   1.1e-40   2.2e-37       7     129 ..      97     219 ..      92     220 .. 0.97

  Alignments for each domain:
  == domain 1  score: 128.2 bits;  conditional E-value: 1.1e-40
                 HHHHHHHHHHHHHTS-HHHHHHHGGGHHHHHHHHHHHHHHTT-HHHHHHHHHHHGGGGGGGHH.HHHHHTT--SHHHHHHSHHHHHHHHS-EEEEEEHH CS
  TFIID_NTD2   7 yekayelLkkwiessldiykpeLsrllyPvFvhlyLelvakgaeeeakkFfekfkedhealhkedlkkLasisspehleenelakafrenkyriklska 105
                 + +ay++L +w+ ssl+iyk+eL ++lyPvFvh+yLelv+k+++eea+kF++k+k +h+++h +d+ +L+s+++pe +++ne+ k++ ++k+ i+ls+a
  EFC39746.1  97 FLQAYQSLTDWVFSSLEIYKNELIQVLYPVFVHCYLELVSKNHSEEARKFLNKYKTQHSHFHYDDILTLQSLQTPEIVNQNEFSKRLLSHKFIIRLSEA 195
                 679************************************************************************************************ PP

                 HHHHHHHHHHHTT-HHHHHHHHHH CS
  TFIID_NTD2 106 afelLlrfLeekekavllkilneh 129
                 +f+lL++fL+++++  ll+iln++
  EFC39746.1 196 SFHLLMKFLQDSSELRLLSILNRF 219
                 *********************986 PP

>> ANAPC4_WD40  Anaphase-promoting complex subunit 4 WD40 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0       2.8   5.5e+03      49      66 ..     392     409 ..     391     425 .. 0.78
   2 !   11.6   0.0   0.00014      0.27      38      81 ..     449     492 ..     442     502 .. 0.86
   3 !   16.6   0.0   3.6e-06    0.0073       2      76 ..     498     571 ..     497     577 .. 0.82
   4 !   15.8   0.0   6.2e-06     0.012      38      88 ..     575     624 ..     570     626 .. 0.87
   5 ?    5.6   0.0      0.01        20      38      67 ..     617     646 ..     613     661 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 2.8
  ANAPC4_WD40  49 dgklLavaysdgevrlld 66 
                  +g ++a +++d++++  +
   EFC39746.1 392 NGPVIAAGFADSTIKCWN 409
                  678888888888887655 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00014
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvkse 81 
                  ++ v sL+++ d + L  + +d +vrl ++++++ v  ++ ++ 
   EFC39746.1 449 SGPVYSLSFNSDQQWLLSSSEDCTVRLWNVNNAESVVVYKGHQY 492
                  67899*****************************9998887776 PP

  == domain 3  score: 16.6 bits;  conditional E-value: 3.6e-06
  ANAPC4_WD40   2 swcptmDLiAlatedg..ellv.fRlngqrvwtleedkedsevrsLaWkpdgklLavaysdgevrlldaesgkvvhsl 76 
                  s++pt  ++A a++d   +l+v  R+   rv+ +    +   v++++++p+ +  a + sd +vrl d+++g++++ +
   EFC39746.1 498 SFSPTDYMFATASHDRtaRLWVtDRVTPVRVFAG----HLADVECVKFHPNCNYVATGSSDKTVRLWDVQTGECMRMF 571
                  6888888888888775224665348888899988....8899*******************************99876 PP

  == domain 4  score: 15.8 bits;  conditional E-value: 6.2e-06
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrlldaesgkvvhslsvksekavtclg 88 
                   ++++ La+++dg+  a a +dg+v + d+ sgk+  ++  +++  v +l+
   EFC39746.1 575 HGSINTLAFSHDGRYCASAGDDGQVLVWDIGSGKIAYKFIGHTK-PVWSLD 624
                  6789*********************************9977766.466665 PP

  == domain 5  score: 5.6 bits;  conditional E-value: 0.01
  ANAPC4_WD40  38 dsevrsLaWkpdgklLavaysdgevrllda 67 
                   + v sL ++ ++++La a  d++vr+ ++
   EFC39746.1 617 TKPVWSLDFNRNDTFLASASLDSTVRVWSM 646
                  67899*********************9875 PP

>> Nup160  Nucleoporin Nup120/160
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.8   0.8     0.019        37     228     253 ..     459     484 ..     439     520 .. 0.84
   2 !   13.5   0.0   1.1e-05     0.021     225     255 ..     538     570 ..     532     607 .. 0.85
   3 !    7.9   0.1   0.00054       1.1     229     280 ..     628     686 ..     620     705 .. 0.67

  Alignments for each domain:
  == domain 1  score: 2.8 bits;  conditional E-value: 0.019
                 .TTTEEEEEETT-EEEEEETTTTEEE CS
      Nup160 228 igqtylfalsrdgkLrvWnlltgkcl 253
                 ++q+ l++ s d ++r+Wn++++  +
  EFC39746.1 459 SDQQWLLSSSEDCTVRLWNVNNAESV 484
                 39999****************98655 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 1.1e-05
                 ......TTTEEEEEETT-EEEEEETTTTEEEEE CS
      Nup160 225 vvei..gqtylfalsrdgkLrvWnlltgkclat 255
                 +v+   + +y+++ s+d+++r+W+++tg c++ 
  EFC39746.1 538 CVKFhpNCNYVATGSSDKTVRLWDVQTGECMRM 570
                 565566789*********************986 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.00054
                 TTTEEEEEETT-EEEEEETTTTEEEEEEE--........-SSSTTS--SSEESEEESSS CS
      Nup160 229 gqtylfalsrdgkLrvWnlltgkclatidll.......rdeeaqdessskstldpaess 280
                 ++t+l+++s+d ++rvW+  +   + + + +       +++  + ++ +  +++p++++
  EFC39746.1 628 NDTFLASASLDSTVRVWSMFDTIDTGSVEGSqsaaqilKEKKLELDKHKIISKEPYKTY 686
                 789***************97766665544443455555444444444444444555555 PP

>> Ge1_WD40  WD40 region of Ge1, enhancer of mRNA-decapping protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.7   0.0    0.0063        13     159     220 ..     419     482 ..     410     485 .. 0.84
   2 !    4.9   0.0    0.0054        11     146     217 ..     483     563 ..     477     570 .. 0.73
   3 !    5.5   0.0    0.0034       6.9     184     216 ..     572     604 ..     566     608 .. 0.89
   4 ?    0.4   0.0      0.13   2.6e+02     190     217 ..     620     647 ..     606     654 .. 0.80

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0063
    Ge1_WD40 159 svdmiaskygsgelsveeiee.gllkieehs.liveaafspdGtalatasedGevkffqvyled 220
                 + +  +++y+s++l+ +e++e  +  +  hs  + + +f +d   l  +sed +v+++ v+  +
  EFC39746.1 419 NTKSYQRNYESINLEDNENREcQYDTLIGHSgPVYSLSFNSDQQWLLSSSEDCTVRLWNVNNAE 482
                 556778999****99999988455566777769**************************98765 PP

  == domain 2  score: 4.9 bits;  conditional E-value: 0.0054
    Ge1_WD40 146 llvltrgdkaeiwsvdmiaskygsgelsveeieegllkieehsl.........iveaafspdGtalatasedGevkffqvy 217
                  +v+ +g++  +w+v+   ++y    +s +++ +  +  + ++          + +  f p+   +at s+d +v+++ v 
  EFC39746.1 483 SVVVYKGHQYAVWNVSFSPTDYMFATASHDRTARLWVTDRVTPVrvfaghladVECVKFHPNCNYVATGSSDKTVRLWDVQ 563
                 567788899999999988888887777777666654444433334455555559999999999999999999999999986 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0034
    Ge1_WD40 184 ieehsliveaafspdGtalatasedGevkffqv 216
                 i +h  i + afs dG   a a  dG+v  + +
  EFC39746.1 572 IGHHGSINTLAFSHDGRYCASAGDDGQVLVWDI 604
                 67888999********************99987 PP

  == domain 4  score: 0.4 bits;  conditional E-value: 0.13
    Ge1_WD40 190 iveaafspdGtalatasedGevkffqvy 217
                 + +  f  + t la as d +v+ + ++
  EFC39746.1 620 VWSLDFNRNDTFLASASLDSTVRVWSMF 647
                 5566788889**************9887 PP

>> LisH  LisH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.1   1.2e-05     0.024       6      27 .]      36      57 ..      35      57 .. 0.96

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.2e-05
                HHHHHHHHCT-HHHHHHHHHHT CS
        LisH  6 LIydYLvkeGyeetAeaFekEa 27
                L+  YL+  Gy+ + +a+e+Ea
  EFC39746.1 36 LVIKYLQQQGYHRSLKALEEEA 57
                8999*****************8 PP

>> WD40_like  WD40-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.012        23       2      50 ..     451     499 ..     450     517 .. 0.86
   2 ?    6.1   0.0     0.003         6       5      57 ..     538     590 ..     534     612 .. 0.78
   3 ?    1.5   0.0     0.075   1.5e+02       5      81 ..     580     655 ..     576     669 .. 0.73
   4 ?   -2.5   0.0       1.3   2.6e+03     266     294 ..     679     707 ..     676     709 .. 0.81

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.012
   WD40_like   2 eiYsidiskkgslilyGgkddkctvlkleslesvsivesfedSvifvkl 50 
                 ++Ys+ ++ + + +l  ++d ++++ ++++ esv + ++ +  v  v +
  EFC39746.1 451 PVYSLSFNSDQQWLLSSSEDCTVRLWNVNNAESVVVYKGHQYAVWNVSF 499
                 69********************************999988877766665 PP

  == domain 2  score: 6.1 bits;  conditional E-value: 0.003
   WD40_like   5 sidiskkgslilyGgkddkctvlkleslesvsivesfedSvifvklldddlil 57 
                  + + ++ ++++ G+ d+++++ +++++e + ++ + + S+    + +d  + 
  EFC39746.1 538 CVKFHPNCNYVATGSSDKTVRLWDVQTGECMRMFIGHHGSINTLAFSHDGRYC 590
                 57788999***********************9999999999877776666554 PP

  == domain 3  score: 1.5 bits;  conditional E-value: 0.075
   WD40_like   5 sidiskkgslilyGgkddkctvlkleslesvsivesfedSvifvklldddlilv.vtlDGtillslleneeeveneki 81 
                 ++ +s++g + +  g+d ++ v ++ s+++ + + + +  v    +  +d +l  ++lD t+        +++++ ++
  EFC39746.1 580 TLAFSHDGRYCASAGDDGQVLVWDIGSGKIAYKFIGHTKPVWSLDFNRNDTFLAsASLDSTVRVWS--MFDTIDTGSV 655
                 677889999999999999999999999999999999999999999999998885367888883333..3334555555 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 1.3
   WD40_like 266 dketfkllesgvGviydmkfenntiyvgG 294
                 +ke +k + s+   +y++kf+++ ++v G
  EFC39746.1 679 SKEPYKTYYSKQTPVYSLKFTQQDFMVAG 707
                 56777888889999999999999999887 PP

>> Cwf_Cwc_15  Cwf15/Cwc15 cell cycle control protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   1.7       2.7   5.5e+03     127     152 ..      14      35 ..       2      56 .. 0.46
   2 ?   14.3   4.5   1.3e-05     0.025     111     170 ..     243     299 ..     225     308 .. 0.70

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 2.7
                 -------------------------- CS
  Cwf_Cwc_15 127 eesdddsdsdsdddddedetaeLlrE 152
                   +    ++ s++  + de+   ++E
  EFC39746.1  14 MVD----EQTSSSTRNGDEQSDKMKE 35 
                 122....2222222223333333333 PP

  == domain 2  score: 14.3 bits;  conditional E-value: 1.3e-05
                 ------------------------------------------------------------ CS
  Cwf_Cwc_15 111 idaddedseeeeeeeeeesdddsdsdsdddddedetaeLlrELekikreraeekerkere 170
                 +d+d +++++  +++++++d + ++d+d++dd+de +++    +ki  e  e++e++e+ 
  EFC39746.1 243 MDHDIKSQQQ--KKKRKSEDVEGSDDDDSEDDDDEFEAIFGRNKKISWEV-ENREKEEAL 299
                 5666666544..34445566677778888888899999998889998886.455555554 PP

>> TFIIF_alpha  Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.3   1.5         5     1e+04     373     386 ..      11      23 ..       2      38 .. 0.34
   2 ?   13.3   6.7   1.2e-05     0.023     341     426 ..     250     332 ..     242     349 .. 0.57

  Alignments for each domain:
  == domain 1  score: -5.3 bits;  conditional E-value: 5
                  XXXXXXXXXXXXXX CS
  TFIIF_alpha 373 slvkakKkkekkke 386
                  s ++   ++ + + 
   EFC39746.1  11 SNMMVDEQTSS-ST 23 
                  33333332221.11 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 1.2e-05
                  XXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXX CS
  TFIIF_alpha 341 kklkkkkkekdkkdSddeedsddsDideedsvslvkakKk.kekkkeekvdsnessagnsrparpspeqkdskskrkaaseeskspv 426
                  + ++kkk+++++ + +d++ds+d+D++     +++ ++Kk   + ++++ +++ + ++  +p  p++ q + ++++k     +++ +
   EFC39746.1 250 Q-QQKKKRKSEDVEGSDDDDSEDDDDEF---EAIFGRNKKiSWEVENREKEEALAATAVVQPTAPTAPQPSRRGRKKKGAATAQQEI 332
                  2.23333333233333444444444333...34555555515556677778889999999999999998887776666544444433 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (716 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       991  (0.0552736); expected 358.6 (0.02)
Passed bias filter:                      541  (0.0301746); expected 358.6 (0.02)
Passed Vit filter:                        71  (0.00396006); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.78u 0.28s 00:00:01.06 Elapsed: 00:00:00.48
# Mc/sec: 4496.99
//
Query:       EFC39747.1  [L=948]
Description: BRCT domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.4e-10   40.2   0.3    2.3e-09   37.5   0.3    2.5  1  BRCT_2    BRCT domain, a BRCA1 C-terminus domain
      3e-09   36.9   0.2    0.00075   19.5   0.0    3.0  2  BRCT_3    BRCA1 C Terminus (BRCT) domain
    4.1e-08   33.5   0.8    4.1e-08   33.5   0.8    3.6  3  BRCT      BRCA1 C Terminus (BRCT) domain


Domain annotation for each model (and alignments):
>> BRCT_2  BRCT domain, a BRCA1 C-terminus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.5   0.3   3.8e-13   2.3e-09       1      82 [.     359     452 ..     359     455 .. 0.84

  Alignments for each domain:
  == domain 1  score: 37.5 bits;  conditional E-value: 3.8e-13
      BRCT_2   1 ksklFeglrFYindaepspsreklkklIeknGGevveti.....tsa...vyiviaesneee....laekrkrrvvspkyIkdCikkgkllple 82 
                 k+klF ++rF i+++  ++++ekl+k+I++ +G++ ++      +s+   ++++i+e+++++     a   + ++++ ++I+d+i ++kl+  e
  EFC39747.1 359 KKKLFANMRFVISNSLIESDKEKLEKKIKEENGTIIRQLsssnlDSCeigKTVLISEKTSTKptylIALLLDIPILKKDWIFDSITEKKLITDE 452
                 589**********99999*****************6555555554445547788888887779*9999999******************98554 PP

>> BRCT_3  BRCA1 C Terminus (BRCT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.2   0.1   5.7e-06     0.034       3      89 ..     363     450 ..     361     461 .. 0.70
   2 !   19.5   0.0   1.3e-07   0.00075       2      87 ..     494     576 ..     493     586 .. 0.86

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 5.7e-06
      BRCT_3   3 lkdlkillvseqk..efeelWseilklaGaavvkkekseaee.islgkldvvvtdsscpeevlkkaeqlkipvvSteWviQsLIegevlk 89 
                 +++++ ++ ++    + e+l ++ +k   ++++++ +s + + ++ gk +v++++++ ++ +   a  l+ip++ ++W+  s+ e++++ 
  EFC39747.1 363 FANMRFVISNSLIesDKEKLEKK-IKEENGTIIRQLSSSNLDsCEIGK-TVLISEKTSTKPTYLIALLLDIPILKKDWIFDSITEKKLIT 450
                 55566555554433232334444.444555566665555544499999.9999*****************************99998765 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 1.3e-07
      BRCT_3   2 ilkdlkillvseqkefeelWseilklaGaavvkkekseaeeislgkldvvvtdss.cpeevlkkaeqlkipvvSteWviQsLIegev 87 
                 i+ + ++ +  ++ke  + W +il ++Ga + ++ +++++e   g+  ++v ds+ ++ee ++ka+++k+p++  e ++Q +I+ e+
  EFC39747.1 494 IFYGCRVKILGNEKE-LSSWISILVAGGAIIDNELTTQTSE---GSNFIFVKDSNkLTEEDVEKATSMKLPILDGESLLQIVITLER 576
                 8999*********98.899*****99999887777776666...666788999888************************9998665 PP

>> BRCT  BRCA1 C Terminus (BRCT) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.5       1.1   6.9e+03      35      60 ..     196     217 ..     154     233 .. 0.54
   2 !   33.5   0.8   6.9e-12   4.1e-08       2      79 .]     359     443 ..     358     443 .. 0.87
   3 ?    3.4   0.1     0.016        97       4      73 ..     493     565 ..     490     571 .. 0.64

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.1
                 EEESSCSTTSSEEEESSSHSHHHHHH CS
        BRCT  35 kvttevskktthlvvgepesrslkyl 60 
                 +    ++ k     ++e  +++++++
  EFC39747.1 196 ST---LTIKPKAKSTKEK-KEKKEKK 217
                 22...2222222223333.3333333 PP

  == domain 2  score: 33.5 bits;  conditional E-value: 6.9e-12
                 TTTTTTTEEEEEEESTSSHHHHHHHHHHHHTTCEE........ESSCSTTSSEEEESSSHSHHHHHHHHHHTTSEEEETHHHHHHH CS
        BRCT   2 kellfhgckfvitgvldnftrdeleelikehGGkv........ttevskktthlvvgepesrslkylealklnipivheewlldci 79 
                 k +lf ++ fvi ++l + ++++le++ike  G++         ++     t l+  ++ s++  yl al l ipi++ +w++d+i
  EFC39747.1 359 KKKLFANMRFVISNSLIESDKEKLEKKIKEENGTIirqlsssnLDSCEIGKTVLISEKT-STKPTYLIALLLDIPILKKDWIFDSI 443
                 579********************************977766666666666666666666.99999*******************97 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.016
                 TTTTTEEEEEEESTSSHHHHHHHHHHHHTTCEE....ESSCSTTSSEEEESSS.HSHHHHHHHHHHTTSEEEETH CS
        BRCT   4 llfhgckfvitgvldnftrdeleelikehGGkv....ttevskktthlvvgep.esrslkylealklnipivhee 73 
                  +f+gc + i    ++ + +++ +++   G+ +    tt+ s+  ++++v+++  ++ + +++a + + pi++ e
  EFC39747.1 493 RIFYGCRVKI--LGNEKELSSWISILVAGGAIIdnelTTQTSEGSNFIFVKDSnKLTEEDVEKATSMKLPILDGE 565
                 5788888888..666666777788888888888666655555555566666664444445777777777777655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (948 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2542  (0.141781); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                       115  (0.00641419); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.14u 0.38s 00:00:01.52 Elapsed: 00:00:00.57
# Mc/sec: 5049.33
//
Query:       EFC39748.1  [L=219]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
          5    7.6   9.6        3.9    8.0   2.5    2.2  2  Afi1      Docking domain of Afi1 for Arf3 in vesicle traffick


Domain annotation for each model (and alignments):
>> Afi1  Docking domain of Afi1 for Arf3 in vesicle trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.7    0.0035        62      78     126 ..       8      55 ..       2      59 .. 0.58
   2 ?    8.0   2.5   0.00022       3.9      56     120 ..     123     174 ..      90     196 .. 0.52

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0035
        Afi1  78 kkksededdvdeedeeeeddnedldelskdeeek.agegepllyvlnvvn 126
                 +    ++++v+ee+e+   ++ d+++++k ++e+ + ++e ++ +l++v 
  EFC39748.1   8 SPPATQTSEVIEEKEVT--LTADESKVTKEDKENlEITEEYTINYLSLVD 55 
                 33333455666666665..4445545444444555899999999999885 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00022
        Afi1  56 dtsteeeeleeeekknklekrkkkksededdvdeedeeeeddnedldelskdeeekagegeplly 120
                 d+s +ee++ee+  k+kl++rk+kk+ +e+++++ ++ e d +e            + ++++++y
  EFC39748.1 123 DKSLKEEDEEEN-GKSKLRNRKSKKETEETEESNGSKLEADYEE------------NLKKKNPIY 174
                 333333333222.2333333333333322222222222222222............333333444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (219 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1729  (0.0964359); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1274.20
//
Query:       EFC39749.1  [L=237]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
       0.12   10.8  11.8       0.17   10.3  11.8    1.1  1  TMEM214        TMEM214, C-terminal, caspase 4 activator
       0.18   10.6   5.5        0.2   10.4   5.5    1.1  1  Presenilin     Presenilin
       0.85    8.0  11.3        1.1    7.7  11.3    1.0  1  Peptidase_S64  Peptidase family S64
       0.91   10.1  15.7      0.066   13.7   8.7    2.0  2  CFIA_Pcf11     Subunit of cleavage factor IA Pcf11


Domain annotation for each model (and alignments):
>> TMEM214  TMEM214, C-terminal, caspase 4 activator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3  11.8   3.8e-05      0.17      11     115 ..      52     169 ..      46     173 .. 0.77

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 3.8e-05
     TMEM214  11 kksknldkkvlakaekkkiaenapkled............llplkqvktlye.ldfekenkkqnkeqvpekstseaeekkksnkkkkkkksekkkeepk 96 
                 k +k+++kk+++ ++kkk  +++    d            ++pl+  ++ y+ +d + e+++ + +q pe+++ +  ++  ++ ++kkk+s++++ ++ 
  EFC39749.1  52 KTPKKNKKKTKKTQQKKKELSESSEDDDeqaeesesgdeiIIPLSGNRNKYKiVDEDDEEEEMELKQEPEEEMYSLFSQELKRTERKKKQSSSSAPKEL 150
                 4455554433333334443333333333667778889999*************9*****99999999***99999988888888899999999999999 PP

     TMEM214  97 ekkpktledAlkaidvael 115
                 ++k+kt e A+   d +e+
  EFC39749.1 151 STKVKTEEPAIAVCDCSEF 169
                 ***********99999887 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   5.5   4.4e-05       0.2     234     305 ..      54     144 ..      27     203 .. 0.50

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 4.4e-05
  Presenilin 234 eseeeeeaekkkeeasesskeeeseeesseksaqsse.........................seeeseeesseaessaeesseeke.....seessess 302
                 +++++++++k++++++e s+++e+++e++e      e                         +     ee+ e ++++ee+  +       ++e+++++
  EFC39749.1  54 PKKNKKKTKKTQQKKKELSESSEDDDEQAE------EsesgdeiiiplsgnrnkykivdeddE-----EEEMELKQEPEEEMYSLFsqelkRTERKKKQ 141
                 222222222222222222222222222222......223445588888888777766543331.....2222222222211111110000011111111 PP

  Presenilin 303 eee 305
                 +++
  EFC39749.1 142 SSS 144
                 111 PP

>> Peptidase_S64  Peptidase family S64
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7  11.3   0.00024       1.1       8     105 ..      57     149 ..      45     169 .. 0.43

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00024
  Peptidase_S64   8 kkkkkdeeskekksle.psksnskskesgesssslkelrpifesekaseeessaeedsstelaesssekssskqssSlfSks.rktystkqssaks 101
                    +kk  +++++++k++e + +s++++++++es+s  + + p      ++++ +  +ed+++e  e + +++ + +  SlfS++ ++t   k+ s++s
     EFC39749.1  57 NKK--KTKKTQQKKKElSESSEDDDEQAEESESGDEIIIPLS---GNRNKYKIVDEDDEEE--EMELKQEPEEEMYSLFSQElKRTERKKKQSSSS 145
                    222..2222222222202222323334444444344444442...2333333333333333..3455566666778****5423343333333333 PP

  Peptidase_S64 102 sssk 105
                    + ++
     EFC39749.1 146 APKE 149
                    2222 PP

>> CFIA_Pcf11  Subunit of cleavage factor IA Pcf11
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   8.7   1.5e-05     0.066      26      87 ..      42     111 ..      40     114 .. 0.91
   2 ?    0.1   1.8      0.26   1.1e+03      48      71 ..     128     151 ..     107     168 .. 0.44

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.5e-05
                 XXTHHCHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX........HHHHT-EEEE-TTTST CS
  CFIA_Pcf11  26 fkddeivstksssnktskkasknaatqassssanesseksentsls........adlekkyVvVPesstd 87 
                 f dd ivs+ ++++k++kk++k+++++++ s+++e +++++++s s        +  ++ky +V e++++
  EFC39749.1  42 FTDDYIVSSPKTPKKNKKKTKKTQQKKKELSESSEDDDEQAEESESgdeiiiplSGNRNKYKIVDEDDEE 111
                 99*************************999999999999998888899*****99999999999999875 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.26
                 XXXXXXXXXXXXXXXXXXXXXXXX CS
  CFIA_Pcf11  48 naatqassssanesseksentsls 71 
                  +++ + ++ ++++s++s+ ++ls
  EFC39749.1 128 FSQELKRTERKKKQSSSSAPKELS 151
                 333333333333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (237 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2531  (0.141168); expected 358.6 (0.02)
Passed bias filter:                      776  (0.0432818); expected 358.6 (0.02)
Passed Vit filter:                       107  (0.00596798); expected 17.9 (0.001)
Passed Fwd filter:                        22  (0.00122706); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.69u 0.35s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 1396.92
//
Query:       EFC39750.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    4.8e-19   67.9   7.1    4.8e-19   67.9   7.1    1.7  2  Synaptobrevin  Synaptobrevin
    4.4e-05   23.4   0.0    6.8e-05   22.8   0.0    1.3  1  Longin         Regulated-SNARE-like domain
     0.0011   18.0   1.3     0.0012   17.9   1.3    1.1  1  LMBR1          LMBR1-like membrane protein
     0.0025   16.6   0.7      0.003   16.4   0.7    1.1  1  DUF2207        Predicted membrane protein (DUF2207)
      0.003   17.6   0.5     0.0049   16.9   0.5    1.3  1  DUF1676        Protein of unknown function (DUF1676)
  ------ inclusion threshold ------
      0.022   14.7   0.2          5    7.0   0.1    2.2  2  NACHT          NACHT domain
      0.034   14.4   6.6      0.064   13.6   6.6    1.5  1  Sigma_reg_N    Sigma factor regulator N-terminal
      0.052   13.9   2.9      0.069   13.5   2.0    1.7  1  GAT            GAT domain
      0.066   12.9   3.4        0.2   11.4   3.4    1.7  1  EMC3_TMCO1     Integral membrane protein EMC3/TMCO1-like
       0.12   12.5   0.2       0.29   11.3   0.2    1.6  1  YHS            YHS domain
       0.22   11.8   0.2       0.35   11.1   0.2    1.4  1  Shisa          Wnt and FGF inhibitory regulator
       0.73    9.9   4.6        1.5    8.9   4.6    1.5  1  TPPK_C         Thiamine pyrophosphokinase C terminal
        1.5    9.0   3.7        3.9    7.7   3.7    1.7  1  DUF2749        Protein of unknown function (DUF2749)
        1.6    8.6   5.8        3.1    7.7   5.8    1.5  1  ODV-E18        Occlusion-derived virus envelope protein ODV-E
        8.9    7.4   9.3          6    7.9   6.8    2.1  2  DUF4834        Domain of unknown function (DUF4834)


Domain annotation for each model (and alignments):
>> Synaptobrevin  Synaptobrevin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.1       2.7   3.2e+03      12      25 ..      79      93 ..      69      99 .. 0.70
   2 !   67.9   7.1     4e-22   4.8e-19       2      87 ..     108     193 ..     107     195 .. 0.91

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 2.7
                   HHCCCC.HHCCHHHH CS
  Synaptobrevin 12 vdevkd.imkeNidk 25
                   +dev++ ++k+N+dk
     EFC39750.1 79 IDEVENeTLKNNLDK 93
                   678876145666776 PP

  == domain 2  score: 67.9 bits;  conditional E-value: 4e-22
                    XXHHHHHHHHHHCCCCHHCCHHHHCHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHTXXXXXXXXXXXXXXXXXXXXXX CS
  Synaptobrevin   2 ndklakikaevdevkdimkeNidkvlergekldeLvdktenLqssaqqFkkqarklkrkmwwknmkliiililvvlililiiiivi 87 
                    ndk++++++e+d+v+d+m eN+dk+l+++  +d L + te+L+++ ++F++  +klk  m  + + +i+i i++++i+i ii+iv+
     EFC39750.1 108 NDKIQRLQNEIDKVRDVMVENVDKILANQVVMDGLIETTEELAQQGEEFQRGGKKLKWSMRKRLIIIILIAIIIFAIIIAIIVIVL 193
                    89**********************************************************99999777777777777777777765 PP

>> Longin  Regulated-SNARE-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   5.6e-08   6.8e-05       3      59 ..      31      86 ..      29     104 .. 0.89

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 5.6e-08
      Longin  3 lilkkishsspqkltythdsytfhylaedgltylviadesyprrlaFafLeeikreF 59
                ++++k+++++  k  +t+d+ ++++  ++++ y +ia+++ ++r+  ++++e+++e 
  EFC39750.1 31 KVIPKLERTN-HKRVLTNDDNNIYVKYSGRYYYFCIATQEIKQRVSWSLIDEVENET 86
                6899998665.999999999*********************************9985 PP

>> LMBR1  LMBR1-like membrane protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.9   1.3     1e-06    0.0012     256     374 ..      81     195 ..      16     210 .. 0.64

  Alignments for each domain:
  == domain 1  score: 17.9 bits;  conditional E-value: 1e-06
       LMBR1 256 eeiaeklks..nenkteeslaklekqlikalqkrertekqwkrllekalelediiknksskekefksses..srrgefakqgklkltptleyywaklll 350
                 e+ +e+lk+  ++n  +e+++  ++    ++q+ +++ ++ +  + +   + +i+ n+   +  ++ +e+  ++ +ef + g     ++l++ ++k+l 
  EFC39750.1  81 EVENETLKNnlDKNLLKEKVKFYNNPDNDKIQRLQNEIDKVRDVMVEN--VDKILANQVVMDGLIETTEElaQQGEEFQRGG-----KKLKWSMRKRLI 172
                 233333333333333555666666667777999999999999988887..79999999999999999999955555665553.....477788888777 PP

       LMBR1 351 plvllilsiilvllsiiiilselt 374
                  ++ li+ ii++++++ii+++ ++
  EFC39750.1 173 -IIILIAIIIFAIIIAIIVIVLIS 195
                 .55555555555555555553232 PP

>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.7   2.5e-06     0.003     327     417 ..      79     191 ..      28     202 .. 0.64

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.5e-06
     DUF2207 327 fdkseeg..ks.......lkeikkyakkskkkakkfkkalkkwksavkk.......................kergyfdkkgkkklkklsalglgliil 393
                  d++e++  k+       +++ k y + +++k ++++++++k+++ + +                       ++ + f++ gkk +++++  ++++i++
  EFC39750.1  79 IDEVENEtlKNnldknllKEKVKFYNNPDNDKIQRLQNEIDKVRDVMVEnvdkilanqvvmdglietteelaQQGEEFQRGGKKLKWSMRKRLIIIILI 177
                 33333332222555455445555555555556677777777766666667777************9999999889999999888888888877777777 PP

     DUF2207 394 glilillallllvlllvfllilll 417
                 ++i++ ++++ +v          +
  EFC39750.1 178 AIIIFAIIIAIIV----------I 191
                 7776543332222..........1 PP

>> DUF1676  Protein of unknown function (DUF1676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.5   4.1e-06    0.0049      52     153 ..     106     200 ..      67     201 .. 0.61

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 4.1e-06
     DUF1676  52 eelsreeeeare........eelekllleklerflkshslevklpeeldaegaeesisrsleedneegRkkkkkkkklkkmllplllalklklklLlpl 142
                 + ++       +        +++++ ++e+++++l++  +   l e+++ e a++     +e   + g kk  k   +k  ++++l+a+ + + +++++
  EFC39750.1 106 PDND-------KiqrlqneiDKVRDVMVENVDKILANQVVMDGLIETTE-ELAQQG----EE-F-QRGGKKL-KWSMRKRLIIIILIAIIIFAIIIAII 189
                 2222.......12233344799***************988888877754.333332....22.1.1344344.33333445555555555888888888 PP

     DUF1676 143 algllallagK 153
                 ++ l+ + agK
  EFC39750.1 190 VIVLISVFAGK 200
                 88899999998 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.7   0.0     0.011        13      84     122 ..       6      41 ..       1      54 [. 0.70
   2 ?    7.0   0.1    0.0042         5      63     104 ..     112     158 ..     108     179 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.011
                 EEEEE-STT-SS-TCH..........HHHHHCTTTTT--E CS
       NACHT  84 LlilDglDelvtdlgqkekqpvr.tlLselirkkllpeas 122
                  l+ Dg+D ++++++q   q++r +lL + i+k l ++++
  EFC39750.1   6 FLVTDGADVIAEHPSQ---QKLRsVLLDKVIPK-LERTNH 41 
                 6999************...55550566666666.555555 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0042
                 TS--SSS-CCHHHHCCSCCCEE...EEEE-STT-SS-TCH....... CS
       NACHT  63 pepaapvsevwavllelperlL...lilDglDelvtdlgq..kekqp 104
                 + ++ ++++v+ v++e+ +++L    ++Dgl e+ ++l q  +e q+
  EFC39750.1 112 QRLQNEIDKVRDVMVENVDKILanqVVMDGLIETTEELAQqgEEFQR 158
                 567888999**********************9999999885544444 PP

>> Sigma_reg_N  Sigma factor regulator N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   6.6   5.3e-05     0.064       9      45 ..     168     205 ..     161     211 .] 0.71

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 5.3e-05
  Sigma_reg_N   9 rksilrivlislivlllifvil.vvtllylaekegnkl 45 
                  rk ++ i+li++i++ +i++i+ +v+++ +a k +++ 
   EFC39750.1 168 RKRLIIIILIAIIIFAIIIAIIvIVLISVFAGKGSSNN 205
                  78899999999999999999998888888844444333 PP

>> GAT  GAT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   2.0   5.8e-05     0.069       5      73 ..      94     158 ..      88     161 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 5.8e-05
         GAT   5 klLsemLsstepdeellenellkeLyetckamqpriqklieetadeedllaelLqlNDeLnnvlerYer 73 
                 +lL+e ++ ++++    +n+ ++ L +++ +++  +++ ++++  ++ +++ l+++ +eL +  e ++r
  EFC39750.1  94 NLLKEKVKFYNNP----DNDKIQRLQNEIDKVRDVMVENVDKILANQVVMDGLIETTEELAQQGEEFQR 158
                 5899999999855....5*************************666669999********998887776 PP

>> EMC3_TMCO1  Integral membrane protein EMC3/TMCO1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   3.4   0.00017       0.2      24     112 ..      64     188 ..      62     199 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00017
  EMC3_TMCO1  24 giltgllsellqkllidkkkmekeqkrekelqkrarelqkngdklklkklekrqeelmedqsem................................... 87 
                 +i+t+ + + +++ lid    e+e  +++  ++  +e  k +++   +k+++ q+e+ +    m                                   
  EFC39750.1  64 CIATQEIKQRVSWSLIDEV--ENETLKNNLDKNLLKEKVKFYNNPDNDKIQRLQNEIDKVRDVMvenvdkilanqvvmdglietteelaqqgeefqrgg 160
                 788888899999***9999..88888888888889999999999999*************9999*********************************** PP

  EMC3_TMCO1  88 ..mmdqmkpmivtmipq.iliffwlnsf 112
                   ++ +m++ ++++i++ i+if+ + ++
  EFC39750.1 161 kkLKWSMRKRLIIIILIaIIIFAIIIAI 188
                 **66666555555555505555555544 PP

>> YHS  YHS domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.2   0.00024      0.29      10      29 ..      45      64 ..      40      67 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00024
         YHS 10 vdkekaeekseYkGkeYyFc 29
                ++++    +++Y G+ YyFc
  EFC39750.1 45 LTNDDNNIYVKYSGRYYYFC 64
                678888899*********** PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.2    0.0003      0.35      80     119 ..     169     205 ..     130     211 .] 0.62

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.0003
       Shisa  80 kdiyvpvlivktifivfvivgvvvivcccgclkkkqrekr 119
                 k     ++i+  ++i+f i+++++++++++++  k+++++
  EFC39750.1 169 K---RLIIIILIAIIIFAIIIAIIVIVLISVFAGKGSSNN 205
                 2...356666777777777788888888888888877665 PP

>> TPPK_C  Thiamine pyrophosphokinase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   4.6    0.0013       1.5      16      37 ..     177     199 ..     171     205 .. 0.88

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.0013
      TPPK_C  16 llllvlAaLvAvavallvsp.ag 37 
                 ++ ++ A+++A++v++l+s  ag
  EFC39750.1 177 IAIIIFAIIIAIIVIVLISVfAG 199
                 7889**************97666 PP

>> DUF2749  Protein of unknown function (DUF2749)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   3.7    0.0033       3.9       1      37 [.     167     206 ..     167     210 .. 0.65

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0033
     DUF2749   1 msprilIvlvia...vaagagtilwlvvqpragtsgsgea 37 
                 m++r +I++ ia    a+  + i+ +++   ag  +s+++
  EFC39750.1 167 MRKRLIIIILIAiiiFAIIIAIIVIVLISVFAGKGSSNNN 206
                 7788888887774334555666666666666888888765 PP

>> ODV-E18  Occlusion-derived virus envelope protein ODV-E18
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   5.8    0.0026       3.1      25      59 ..     174     208 ..     166     211 .] 0.74

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0026
     ODV-E18  25 sllltilvvlviiillvllvqssstGsdssssnan 59 
                  +l++i++  +ii+++v+++ s  +G+ ss  n+ 
  EFC39750.1 174 IILIAIIIFAIIIAIIVIVLISVFAGKGSSNNNST 208
                 56788888888888888888888888888877754 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0       6.3   7.6e+03      78      94 ..      38      55 ..      30      57 .. 0.68
   2 ?    7.9   6.8     0.005         6       3      39 ..     171     207 ..     169     211 .] 0.71

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 6.3
     DUF4834 78 eakrkkiFekdeGE.YVd 94
                + ++k++ ++d+ + YV 
  EFC39750.1 38 RTNHKRVLTNDDNNiYVK 55
                467888887776544665 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.005
     DUF4834   3 fLlfilifiiailviglsilsvilrtvfglgsrkkss 39 
                 ++ +ili ii+ ++i ++i+ v++  + g+gs +++s
  EFC39750.1 171 LIIIILIAIIIFAIIIAIIVIVLISVFAGKGSSNNNS 207
                 4566688888888888888888888887888776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2728  (0.152156); expected 358.6 (0.02)
Passed bias filter:                     1121  (0.0625244); expected 358.6 (0.02)
Passed Vit filter:                       161  (0.00897987); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.63u 0.35s 00:00:00.98 Elapsed: 00:00:00.49
# Mc/sec: 1284.38
//
Query:       EFC39751.1  [L=665]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-22   77.4  18.0    9.4e-06   25.3   0.0    9.4  9  LRR_6           Leucine Rich repeat
    1.8e-15   56.4  16.6    3.3e-05   23.6   0.7    5.0  4  LRR_8           Leucine rich repeat
    8.8e-14   51.4  27.6     0.0063   16.9   1.2    7.2  8  LRR_4           Leucine Rich repeats (2 copies)
    2.1e-12   46.9   0.1    6.5e-12   45.3   0.1    1.9  1  Lip_prot_lig_C  Bacterial lipoate protein ligase C-terminus
    9.1e-05   22.5  13.5        1.9    9.3   2.2    7.2  6  LRR_1           Leucine Rich Repeat
     0.0011   18.9   0.0     0.0079   16.1   0.0    2.2  1  BPL_LplA_LipB   Biotin/lipoate A/B protein ligase family
  ------ inclusion threshold ------
       0.15   12.7   3.5        1.2    9.7   0.2    3.2  3  ING             Inhibitor of growth proteins N-terminal histo


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.1       4.8   1.2e+04      12      20 ..     337     345 ..     335     346 .. 0.81
   2 ?    2.9   0.1     0.056   1.4e+02      15      23 ..     422     430 ..     420     431 .. 0.89
   3 !    9.8   0.0   0.00034      0.86       4      23 ..     435     454 ..     432     455 .. 0.90
   4 !   19.1   0.1   3.5e-07   0.00089       3      19 ..     489     505 ..     487     510 .. 0.90
   5 ?    5.2   0.0      0.01        26       4      23 ..     514     533 ..     511     534 .. 0.88
   6 !    9.8   0.5   0.00034      0.86       4      24 .]     538     558 ..     535     558 .. 0.89
   7 !   25.3   0.0   3.7e-09   9.4e-06       3      21 ..     586     604 ..     584     607 .. 0.88
   8 !    5.4   0.0    0.0085        22       5      23 ..     612     630 ..     609     631 .. 0.91
   9 ?    3.8   0.0     0.028        71       5      18 ..     636     649 ..     635     649 .. 0.90

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 4.8
       LRR_6  12 gNdIgDeGa 20 
                  Nd++ eG+
  EFC39751.1 337 NNDFSKEGI 345
                 799****96 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.056
       LRR_6  15 IgDeGaeaL 23 
                 IgDeGa+ +
  EFC39751.1 422 IGDEGASMI 430
                 9*****988 PP

  == domain 3  score: 9.8 bits;  conditional E-value: 0.00034
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt+Ld+s+ +I+  G+ ++
  EFC39751.1 435 QLTYLDISFTGISYNGMRSI 454
                 59**************9987 PP

  == domain 4  score: 19.1 bits;  conditional E-value: 3.5e-07
       LRR_6   3 thLteLdLsgNdIgDeG 19 
                  +Lt+Ld+++N+IgDeG
  EFC39751.1 489 KKLTHLDITYNEIGDEG 505
                 68**************9 PP

  == domain 5  score: 5.2 bits;  conditional E-value: 0.01
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt+L++  N++ +eG + +
  EFC39751.1 514 NLTYLEMPNNQLRNEGFKMI 533
                 8***************7766 PP

  == domain 6  score: 9.8 bits;  conditional E-value: 0.00034
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt+L++s Nd++ e ++ L+
  EFC39751.1 538 NLTHLNISNNDFNCESMKHLC 558
                 8***********999999887 PP

  == domain 7  score: 25.3 bits;  conditional E-value: 3.7e-09
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                  +LteLdLs+NdIg+eGa+
  EFC39751.1 586 KYLTELDLSCNDIGNEGAK 604
                 68****************8 PP

  == domain 8  score: 5.4 bits;  conditional E-value: 0.0085
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 L++L+L+  +++ eG++ L
  EFC39751.1 612 LQSLQLAQTNLDSEGVKYL 630
                 99**************987 PP

  == domain 9  score: 3.8 bits;  conditional E-value: 0.028
       LRR_6   5 LteLdLsgNdIgDe 18 
                 Lt Ld+s N I+ e
  EFC39751.1 636 LTDLDVSENSIDAE 649
                 99********9876 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.2   0.0    0.0004         1      12      58 ..     421     467 ..     410     469 .. 0.82
   2 !   15.0   0.9     6e-06     0.015      22      61 .]     486     525 ..     482     525 .. 0.94
   3 !   17.2   6.5   1.2e-06    0.0031       2      59 ..     514     571 ..     514     573 .. 0.94
   4 !   23.6   0.7   1.3e-08   3.3e-05       2      61 .]     587     646 ..     584     647 .. 0.97

  Alignments for each domain:
  == domain 1  score: 9.2 bits;  conditional E-value: 0.0004
                 --SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--S CS
       LRR_8  12 rltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsg 58 
                 r+ + + ++  ++++L++Ld+s   ++    +++ +L++L++L  s+
  EFC39751.1 421 RIGDEGASMIGQMKQLTYLDISFTGISYNGMRSIGQLTNLTQLIFSS 467
                 555556778889******************************97665 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 6e-06
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 ++l++L++Ld+++N++     + +s L +L++L + +N+L
  EFC39751.1 486 RNLKKLTHLDITYNEIGDEGSQFISELLNLTYLEMPNNQL 525
                 79************************************98 PP

  == domain 3  score: 17.2 bits;  conditional E-value: 1.2e-06
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 nLt+L   nN+l + + ++ ++l+nL++L++snN  +  s + +  L++L+sL   ++
  EFC39751.1 514 NLTYLEMPNNQLRNEGFKMISKLENLTHLNISNNDFNCESMKHLCELKNLTSLEAFNT 571
                 79***************************************************87665 PP

  == domain 4  score: 23.6 bits;  conditional E-value: 1.3e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  Lt+LdLs+N + + + +  + l++L++L+L + +l++   + ++ L +L+ Ld+s N +
  EFC39751.1 587 YLTELDLSCNDIGNEGAKYVSELKQLQSLQLAQTNLDSEGVKYLVRLDQLTDLDVSENSI 646
                 59*******************************************************986 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.014        37      19      33 ..     430     444 ..     396     450 .. 0.78
   2 !    8.4   0.1    0.0012         3       1      29 [.     434     464 ..     434     474 .. 0.76
   3 !    8.0   0.1    0.0016       4.1      19      37 ..     485     502 ..     478     512 .. 0.80
   4 !   16.5   0.3   3.4e-06    0.0087       1      37 [.     489     526 ..     489     531 .. 0.88
   5 !   15.7   4.8   5.9e-06     0.015       2      39 ..     514     549 ..     513     552 .. 0.87
   6 !   16.9   1.2   2.4e-06    0.0063       1      39 [.     561     598 ..     561     602 .. 0.88
   7 !   12.4   0.4   6.6e-05      0.17       1      40 [.     610     647 ..     610     655 .. 0.90
   8 ?   -0.7   0.0      0.86   2.2e+03      19      30 ..     654     665 .]     645     665 .] 0.77

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.014
                 HHH-TT--EEE-.-S CS
       LRR_4  19 leklpnLkeLdLsgN 33 
                 ++++++L++Ld+s+ 
  EFC39751.1 430 IGQMKQLTYLDISFT 444
                 557********9764 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0012
                 SS--EEE--SS---E-S-..HHH-TT--EEE CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLd 29 
                 ++L++Ld+s + ++  +   +++l+nL++L 
  EFC39751.1 434 KQLTYLDISFTGISYNGMrsIGQLTNLTQLI 464
                 589******98888766665447*****994 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0016
                 HHH-TT--EEE-.-S---- CS
       LRR_4  19 leklpnLkeLdLsgNnlit 37 
                 l++l++L++Ld++ N  i+
  EFC39751.1 485 LRNLKKLTHLDITYN-EIG 502
                 778*********888.554 PP

  == domain 4  score: 16.5 bits;  conditional E-value: 3.4e-06
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlit 37 
                 ++L++Ld+  N + d ++ + + l nL++L +  Nn+++
  EFC39751.1 489 KKLTHLDITYNEIGDEGSqFISeLLNLTYLEM-PNNQLR 526
                 69************999996655*********.999996 PP

  == domain 5  score: 15.7 bits;  conditional E-value: 5.9e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39 
                 nL++L   nNql+  ++  ++kl nL++L++s+N    d+
  EFC39751.1 514 NLTYLEMPNNQLRNEGFkmISKLENLTHLNISNN----DF 549
                 9************777777779*********999....54 PP

  == domain 6  score: 16.9 bits;  conditional E-value: 2.4e-06
                 SS--EEE--SS---E-S-..HHH.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitdl 39 
                 +nL++L  +n+ +t+ +   +++ l+ L+eLdLs N    d+
  EFC39751.1 561 KNLTSLEAFNTGITSNDVklIANhLKYLTELDLSCN----DI 598
                 79****************975566*********888....76 PP

  == domain 7  score: 12.4 bits;  conditional E-value: 6.6e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-----GG CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdld 40 
                 ++L++L L++++l + +   l  l++L+ Ld+s+N    ++d
  EFC39751.1 610 KQLQSLQLAQTNLDSEGVkyLVRLDQLTDLDVSEN----SID 647
                 58************999998778************....665 PP

  == domain 8  score: -0.7 bits;  conditional E-value: 0.86
                 HHH-TT--EEE- CS
       LRR_4  19 leklpnLkeLdL 30 
                 l+ +++L+eL++
  EFC39751.1 654 LNEMKQLEELSI 665
                 56799***9986 PP

>> Lip_prot_lig_C  Bacterial lipoate protein ligase C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.3   0.1   2.6e-15   6.5e-12       1      63 [.     286     348 ..     286     371 .. 0.94

  Alignments for each domain:
  == domain 1  score: 45.3 bits;  conditional E-value: 2.6e-15
                     --EESEEEEEEETTEEEEEEEEEETTEEEEEEEEESBSSSSHCHHHHHHHTTSBSSHHHHHHH CS
  Lip_prot_lig_C   1 spefnvkkkkrfdwGtvevrldvekgiIkdikiyGDffgpkdieeleekLigvkyekeaieea 63 
                     +p+f+++ +++fdwG v++++d ++g+I ++k+y+D + p  +e +ee L++  ++ke i ++
      EFC39751.1 286 TPDFSNNIETKFDWGLVDLHIDYKAGKIANVKMYSDVLFPVFVEIVEEGLVNNDFSKEGIDNF 348
                     69********************************************************99875 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0      0.98   2.5e+03       2      11 ..     436     445 ..     435     464 .. 0.73
   2 !    8.1   0.0    0.0019       4.8       1      21 [.     490     510 ..     490     512 .. 0.83
   3 ?    0.8   0.1      0.47   1.2e+03       1      15 [.     514     528 ..     514     536 .. 0.75
   4 !    9.3   2.2   0.00075       1.9       1      22 [.     538     559 ..     538     586 .. 0.87
   5 ?    4.2   0.1     0.037        95       2      17 ..     588     603 ..     587     624 .. 0.81
   6 ?   -1.5   0.0       2.7     7e+03       2      12 ..     636     646 ..     635     657 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.98
       LRR_1   2 LrhLdLsnnp 11 
                 L++Ld+s   
  EFC39751.1 436 LTYLDISFTG 445
                 99***97654 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.0019
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L+hLd+++n +++ +++ ++
  EFC39751.1 490 KLTHLDITYNEIGDEGSQFIS 510
                 7***********888877766 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.47
       LRR_1   1 nLrhLdLsnnpllgl 15 
                 nL++L + nn+l + 
  EFC39751.1 514 NLTYLEMPNNQLRNE 528
                 8*********99544 PP

  == domain 4  score: 9.3 bits;  conditional E-value: 0.00075
       LRR_1   1 nLrhLdLsnnpllglppnsfqn 22 
                 nL+hL++snn + + +  +++ 
  EFC39751.1 538 NLTHLNISNNDFNCESMKHLCE 559
                 8**********97777777664 PP

  == domain 5  score: 4.2 bits;  conditional E-value: 0.037
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L++LdLs n +++ ++
  EFC39751.1 588 LTELDLSCNDIGNEGA 603
                 99*******9965554 PP

  == domain 6  score: -1.5 bits;  conditional E-value: 2.7
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ Ld+s n++
  EFC39751.1 636 LTDLDVSENSI 646
                 8889*999997 PP

>> BPL_LplA_LipB  Biotin/lipoate A/B protein ligase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.0   3.1e-06    0.0079      10     131 .]      85     192 ..      79     192 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 3.1e-06
                    HHHH..GCGGG--TT-EEEEEEESS-B-B--B-TTSEEEEEEEEESS...-CCGTHHHHHHHHHHH.HHHH......HHTT-TTEEEETTTEEEE. CS
  BPL_LplA_LipB  10 tllkeslnsselesgglvvvrrqtgGrnvwhspkgeltyslllspeqktfqnrvlelyvsllvlav.lealgyrdskpgiegipvfikwpnDlyv. 103
                    ++ +++ n++  e++ + +vrr +gG +v+++  g+ ++++l  +e           y  +l +++ +e+l       +  +i+ +  ++nDl + 
     EFC39751.1  85 QNPFKECNLARMEQDDVNLVRRRSGGGAVYQD-MGNSIFTFLSPKE----------SYSKELNFKIlMESL------NNGFNINSELSGRNDLILs 163
                    455678999***********************.6777777666644..........455555555414555......455666666669******9 PP

                    .TTEEEEEEEEEEEETTS-EEEEEEEEEE CS
  BPL_LplA_LipB 104 .ngrKlaGiavtstrgktlhhivigvgvn 131
                      +rK++G+a ++ + +  hh++++++++
     EFC39751.1 164 dCKRKISGSAFKQGKDVCFHHGTMLLNLD 192
                    889**********************9987 PP

>> ING  Inhibitor of growth proteins N-terminal histone-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.2   0.00049       1.2       7      82 ..     343     432 ..     338     440 .. 0.74
   2 ?   -0.2   0.1      0.61   1.6e+03      18      58 ..     486     528 ..     484     543 .. 0.73
   3 ?    1.3   0.0       0.2   5.1e+02      17      45 ..     582     610 ..     579     639 .. 0.78

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00049
                 TSGGGHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..............TS..S-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         ING   7 dsvenLPlelqrnltelreiDakvqellkeidskiekfl..............kngslqknekeeelsriqeelkeaqelldeKiqlaqq 82 
                 + ++n+ +++++++++l +iD   +e+l + ++++++++              k+ +++  +   +l++++   ++a++++de   ++ q
  EFC39751.1 343 EGIDNFESWTKERIKLLPNIDDASKEILTNFSKQLSSWIqfkdcitniekiypKKITHEVLQNITKLEKVNYVDIAAIRIGDEGASMIGQ 432
                 4699***********************************888888777777664444455555555555555555666666665555555 PP

  == domain 2  score: -0.2 bits;  conditional E-value: 0.61
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHH..TS..S-HHHHHHH CS
         ING  18 rnltelreiDakvqellkeidskiekfl..kngslqknekeee 58 
                 rnl++l  +D  ++e+ +e ++ i+++l  +  ++ +n+ ++e
  EFC39751.1 486 RNLKKLTHLDITYNEIGDEGSQFISELLnlTYLEMPNNQLRNE 528
                 89999999******99999999999999775555555555444 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.2
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
         ING  17 qrnltelreiDakvqellkeidskiekfl 45 
                   +l+ l e+D +++++ +e  ++++++ 
  EFC39751.1 582 ANHLKYLTELDLSCNDIGNEGAKYVSELK 610
                 5789999**********999999988877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (665 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.71u 0.33s 00:00:01.04 Elapsed: 00:00:00.52
# Mc/sec: 3861.08
//
Query:       EFC39752.1  [L=808]
Description: rhoGEF domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-36  126.5   2.8    1.4e-36  126.5   2.8    2.5  2  RhoGEF    RhoGEF domain
  ------ inclusion threshold ------
      0.061   13.4   0.1       0.28   11.3   0.0    2.2  2  GIIM      Group II intron, maturase-specific domain
      0.078   13.3   0.0       0.24   11.7   0.0    1.8  1  HA        Helicase associated domain


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  126.5   2.8   2.3e-40   1.4e-36       1     182 []      21     206 ..      21     206 .. 0.91
   2 ?   -1.8   1.4      0.54   3.2e+03      44      44 ..     467     467 ..     369     542 .. 0.55

  Alignments for each domain:
  == domain 1  score: 126.5 bits;  conditional E-value: 2.3e-40
                 HHHHHHHHHHHHHHHHHHHHHHTHCCCHHCT.....CCHHHHHHHHC.TTHHHHHHHHHHHH...HHHHHHHH.HHHTTSS-S-SHHHHHHHHSTHHHH CS
      RhoGEF   1 vikElleTErsYvrdLkvlvevylkplsele.....vlseeeikiiF.snieeilelhrsfl...leeLeerlkeseeqkeaqsigdvflkfadkfkkY 90 
                 ++kE+l+TE++Y+++L +l ++y kpl+el      ++++e  ++iF + +  i + + +++   +e++e   +e+ ++  ++++g++fl++a+ +k Y
  EFC39752.1  21 IMKEILDTEKNYIEELDILEDFYAKPLRELIgqkqkFITKELHSKIFkGDLVIIRKTNGELYgelIENFE---MERANKVPNKTFGQIFLQYAPFIKGY 116
                 789*************************88899999999999999**88999999999555544333333...355888999***************** PP

                 HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHTSGGGTT--HHHHTTHHHHHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHHHHH CS
      RhoGEF  91 seYcsnypnalkllkelskknkkfkafleeaeerpecskldLeslLikPvqRlprYpLLLkellkntpeshpdyealkkaleaikevaseiN 182
                 + Y ++++n+ ++l+  +k+nk +++++++  +r+e+++ +L  lLi+P+qR+prY+LLL+el+++t++ ++dy+ l++al++i+eva+e+N
  EFC39752.1 117 TRYFNEFDNINATLEDIRKNNKPLQQWMDD--QRREAKNKPLGGLLITPIQRVPRYKLLLTELVRYTSPYNKDYSMLQNALKEISEVATELN 206
                 ****************9999999******9..6677799**************************************************998 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.54
                 T CS
      RhoGEF  44 n 44 
                 n
  EFC39752.1 467 N 467
                 2 PP

>> GIIM  Group II intron, maturase-specific domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   4.7e-05      0.28      18      71 ..      99     152 ..      92     158 .. 0.88
   2 ?   -3.6   0.0         2   1.2e+04      14      30 ..     478     494 ..     476     496 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 4.7e-05
        GIIM  18 gvsleelirklnpilrGWanYyrlg.vakrvfskldhyirrrLrrwllrkhkkkk 71 
                 +++ +++  ++ p+++G++ Y++ + +  ++++++ +  ++ L +w+  +++ +k
  EFC39752.1  99 NKTFGQIFLQYAPFIKGYTRYFNEFdNINATLEDI-RKNNKPLQQWMDDQRREAK 152
                 67888999999************************.999*******999988755 PP

  == domain 2  score: -3.6 bits;  conditional E-value: 2
        GIIM  14 rsskgvsleelirklnp 30 
                 +ss+++++ee+++ +n 
  EFC39752.1 478 KSSSKKKQEEMANIVNE 494
                 57788999999998886 PP

>> HA  Helicase associated domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   4.1e-05      0.24      14      48 ..     118     154 ..     114     178 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 4.1e-05
          HA  14 eykaehGhlnvP..ekteenpsLgkWvakqRqqykkg 48 
                 +y +e  + n      +++n++L +W  +qR++ k++
  EFC39752.1 118 RYFNEFDNINATleDIRKNNKPLQQWMDDQRREAKNK 154
                 6778888888777766799**************9654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (808 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1502  (0.0837749); expected 358.6 (0.02)
Passed bias filter:                      566  (0.031569); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.82u 0.35s 00:00:01.17 Elapsed: 00:00:00.55
# Mc/sec: 4412.70
//
Query:       EFC39753.1  [L=388]
Description: DUF367 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-54  182.9   0.0    2.8e-54  182.2   0.0    1.3  1  Ribo_biogen_C    Ribosome biogenesis protein, C-terminal
    5.5e-09   35.7   0.1    1.3e-08   34.5   0.1    1.6  1  RLI              Possible Fer4-like domain in RNase L inhibit
  ------ inclusion threshold ------
      0.073   13.3  11.9       0.12   12.7  11.9    1.3  1  GAGA_bind        GAGA binding protein-like family
          3    6.0  45.4      0.091   11.0  26.3    2.0  2  Nop14            Nop14-like family
        8.2    4.7  10.3         12    4.1  10.3    1.2  1  SID-1_RNA_chan   dsRNA-gated channel SID-1
          9    4.3  15.7         15    3.6  15.7    1.2  1  Hid1             High-temperature-induced dauer-formation pro


Domain annotation for each model (and alignments):
>> Ribo_biogen_C  Ribosome biogenesis protein, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  182.2   0.0   9.2e-58   2.8e-54       1     127 []     199     325 ..     199     325 .. 0.99

  Alignments for each domain:
  == domain 1  score: 182.2 bits;  conditional E-value: 9.2e-58
                    EEE-TT-SSB--GGGHHHHHHT-EEEE---TTT--GGGTTT-E....EB--S-B--STTTTT-BS---HHHHHHHHHHHTT-HHHHHHHHTSSTTH CS
  Ribo_biogen_C   1 ivlspkakkvlspaDreiveksgiavvdcsWarleevkfkklkakeerlLPyLvAaNpvnYgkplkLscvEAlaaalyilglkeeaeellskfkwg 96 
                    +vl+p++k+ +s aDre+v+++g +vvdcsW+ l+ v+f+klk++++rlLPyLvAaNpvnYg+plkLsc+EAla+++yi+glkeea++ll+kfkwg
     EFC39753.1 199 VVLTPQGKQSVSAADREVVKEHGACVVDCSWNCLDMVPFHKLKSPNNRLLPYLVAANPVNYGRPLKLSCAEALAGTMYICGLKEEAKALLAKFKWG 294
                    89********************************************************************************************** PP

                    HHHHHHCHHHHHHH.TT--HHHHHHHHHHHH CS
  Ribo_biogen_C  97 eeFlelnkelleeYakckdseevvevqkeyl 127
                    ++F+eln +lle+Y++ck+s+evv+vq++y+
     EFC39753.1 295 HSFIELNYDLLEAYSQCKNSAEVVAVQQDYI 325
                    ****************************996 PP

>> RLI  Possible Fer4-like domain in RNase L inhibitor, RLI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.5   0.1   4.3e-12   1.3e-08       3      24 ..     163     184 ..     161     191 .. 0.91

  Alignments for each domain:
  == domain 1  score: 34.5 bits;  conditional E-value: 4.3e-12
                 EEEES---------TTHHHHHT CS
         RLI   3 lAivdadqCdPKKCtgkkcarf 24 
                 lA++d+ qCd K+Ctgkk++r+
  EFC39753.1 163 LAMWDFQQCDSKRCTGKKLERM 184
                 9*******************96 PP

>> GAGA_bind  GAGA binding protein-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7  11.9     4e-05      0.12      89     204 ..      51     173 ..      14     184 .. 0.59

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 4e-05
   GAGA_bind  89 kalleednalaalqmlrp...lesqlqeaeapelekeevasselveesavveke.eaakkrqqgk...rpkepkakkakkaarkpkeegedlalkkakr 180
                 ++ +e  ++  +++m r+    e++++e+e+++ ekee++s+e  ees+  e+e +++k++        ++++k+kk+ + +r +++++e+ + k + +
  EFC39753.1  51 YKAMEMLDNESSMEMERKkkpIEDSEEEEEEEKEEKEEEKSEEEEEESEEEEEEeKSEKPKIDDGefqPQRVQKTKKQMRLERLAQRKSEKEKEKPEVK 149
                 555666666677777775222333333333333333333333333333333333344455544332213566677777777777888887666677788 PP

   GAGA_bind 181 sksekksvdlvingielDestiPi 204
                 + ++kk+++  i+    D  +   
  EFC39753.1 150 KEAPKKKTNFPIDLAMWDFQQCDS 173
                 899999999999988888766555 PP

>> Nop14  Nop14-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0  26.3     3e-05     0.091     349     440 ..      58     149 ..       3     163 .. 0.32
   2 ?    1.2  11.1     0.028        84     302     354 ..     330     385 ..     310     388 .] 0.53

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 3e-05
       Nop14 349 eededdfeedddl.veseseeeeeeeeedeeeeedeeeee.....eeeededdlsdleseeeeeedeleeel.leeekkaaeekkekk.....kkkkks 435
                 +++++ ++e +++  e+++eeeeee+ee+eee+++eeeee     eee++e+ + d+ + + +  ++ ++++ l       e     +     ++k+k+
  EFC39753.1  58 DNESSMEMERKKKpIEDSEEEEEEEKEEKEEEKSEEEEEEseeeeEEEKSEKPKIDDGEFQPQRVQKTKKQMrL-------E-----RlaqrkSEKEKE 144
                 22222222221110111111111111111111111111110000011111222222221211111111111121.......1.....121111222222 PP

       Nop14 436 eekak 440
                 + + k
  EFC39753.1 145 KPEVK 149
                 22222 PP

  == domain 2  score: 1.2 bits;  conditional E-value: 0.028
       Nop14 302 eeeekkkkkkke...asaDdldddfvleeeeeeeefglgkgl.ka.taeeeeeededd 354
                 +e+++k+k++++    saDdl  +++++++e+ee  g++++l +  ++ eeee+d+d+
  EFC39753.1 330 KEASSKEKSDSSgniVSADDLYGEYFTKDDENEE-EGVEDDLvEPlSD-EEEEDDDDE 385
                 2333333333335668899988888877755555.4666666322212.111111111 PP

>> SID-1_RNA_chan  dsRNA-gated channel SID-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1  10.3    0.0042        12     151     225 ..      68     146 ..      38     151 .. 0.67

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.0042
  SID-1_RNA_chan 151 eekrvkessssesaseslesvssavrsesessveeesdydtleeiesd....knvirtkkvlvvsdlsrkdkrvlekky 225
                     ++k +++s+++e++++++++ +++ ++e+es+ eee++ +  ++i+      ++v +tkk++ ++ l++++++++++k 
      EFC39753.1  68 KKKPIEDSEEEEEEEKEEKEEEKSEEEEEESEEEEEEEKSEKPKIDDGefqpQRVQKTKKQMRLERLAQRKSEKEKEKP 146
                     333344444444444444444444455555555555555555555533666699**************99988888775 PP

>> Hid1  High-temperature-induced dauer-formation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6  15.7    0.0049        15     569     672 ..      52     151 ..      38     166 .. 0.37

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.0049
        Hid1 569 ealrnltlesaseeiersnesarldsideeeeenssessrieesrsesrspslsevpelksslaitddeskaereksatessssqavsqlremsekara 667
                 +a+  l  es++e +er+++    ds++eeeee+++++++ +e+++e+++ +++e++++k ++  ++ + +  ++++++   +  a+   ++ +ek++ 
  EFC39753.1  52 KAMEMLDNESSME-MERKKK-PIEDSEEEEEEEKEEKEEEKSEEEEEESEEEEEEEKSEKPKIDDGEFQPQRVQKTKKQMRLERLAQR--KSEKEKEKP 146
                 4555555555442.222222.1222222222222222222222222222332333333333333333333333332222222222222..222222222 PP

        Hid1 668 kesae 672
                 + ++e
  EFC39753.1 147 EVKKE 151
                 22222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (388 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2774  (0.154721); expected 358.6 (0.02)
Passed bias filter:                      944  (0.0526521); expected 358.6 (0.02)
Passed Vit filter:                       346  (0.0192983); expected 17.9 (0.001)
Passed Fwd filter:                       112  (0.00624686); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.28u 0.42s 00:00:01.70 Elapsed: 00:00:00.59
# Mc/sec: 1991.33
//
Query:       EFC39754.1  [L=526]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.97    9.7   8.6        2.6    8.3   8.6    1.7  1  RGCC      Response gene to complement 32 protein family


Domain annotation for each model (and alignments):
>> RGCC  Response gene to complement 32 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   8.6   0.00015       2.6      61     110 ..       3      52 ..       1      58 [. 0.93

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00015
        RGCC  61 krrssasvsDsGisdsesadslnrsslsfsdekLnsptasspslssplvv 110
                 krrs+ sv  s  s s s + +++  +++ d   n  tass++lss++v 
  EFC39754.1   3 KRRSTSSVGSSTASSSSSMSVVQQRGFNLYDGSTNHSTASSTTLSSNSVS 52 
                 9*****************************************99988764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (526 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1010  (0.0563333); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.67u 0.34s 00:00:01.01 Elapsed: 00:00:00.53
# Mc/sec: 2992.11
//
Query:       EFC39755.1  [L=248]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.5e-12   46.5   1.2    7.4e-12   45.8   1.2    1.3  1  Gly_transf_sug  Glycosyltransferase sugar-binding region cont


Domain annotation for each model (and alignments):
>> Gly_transf_sug  Glycosyltransferase sugar-binding region containing DXD motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.8   1.2   4.1e-16   7.4e-12      12      95 ..      12      89 ..       3      92 .. 0.74

  Alignments for each domain:
  == domain 1  score: 45.8 bits;  conditional E-value: 4.1e-16
  Gly_transf_sug 12 akahpdyqvvvlskelekvrvaildlefllsdtp....wfeeakkllplfialsDllRlaiLykyGGiYlDtDvivlkslrnsigaee 95
                     + + +++++  +++          l+fl +++     +f   ++l+p  + ++D++Rla+Lyk GG Y+D+D i+lk+l ++++ ++
      EFC39755.1 12 YESNSKFKYIYYNDDAV--------LQFLIDNYGensdEFHAFNNLIPF-AYKIDFWRLAVLYKIGGYYSDIDSILLKDL-DKWIENN 89
                    45566677777777755........555555533333477766667765.99****************************.***9776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (248 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       467  (0.0260472); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1514.36
//
Query:       EFC39756.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1184  (0.0660383); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.50
# Mc/sec: 740.10
//
Query:       EFC39757.1  [L=605]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (605 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       955  (0.0532657); expected 358.6 (0.02)
Passed bias filter:                      314  (0.0175135); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.69u 0.33s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 3360.15
//
Query:       EFC39758.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.1e-13   48.2  10.7     0.0047   16.9   0.2    6.9  7  LRR_6     Leucine Rich repeat
    7.2e-13   48.5  15.2      6e-07   29.7   0.7    5.1  6  LRR_4     Leucine Rich repeats (2 copies)
    1.8e-12   46.8   9.6    0.00016   21.4   0.6    4.2  3  LRR_8     Leucine rich repeat
  ------ inclusion threshold ------
      0.014   15.9  12.3        5.3    8.0   0.1    5.5  4  LRR_1     Leucine Rich Repeat
       0.19   11.7   0.8         22    5.0   0.1    3.0  3  Stn1_C    Telomere capping C-terminal wHTH


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.2     0.007        25       6      17 ..      24      35 ..      22      36 .. 0.85
   2 ?    0.6   0.0      0.22     8e+02      13      23 ..      55      65 ..      44      66 .. 0.76
   3 ?   -1.2   0.0      0.83     3e+03       4      17 ..      70      83 ..      68      84 .. 0.75
   4 !   12.2   0.0   4.3e-05      0.15       5      23 ..      95     113 ..      92     114 .. 0.91
   5 !    6.4   0.0     0.003        11      12      24 .]     140     152 ..     139     152 .. 0.87
   6 !    7.1   0.1    0.0017       6.3       4      23 ..     156     175 ..     155     176 .. 0.91
   7 !   16.9   0.2   1.3e-06    0.0047       3      24 .]     180     201 ..     178     201 .. 0.95

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.007
       LRR_6  6 teLdLsgNdIgD 17
                 +Ld+s+N I++
  EFC39758.1 24 IALDISFNSIDN 35
                58********87 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.22
       LRR_6 13 NdIgDeGaeaL 23
                Nd++ eG+++L
  EFC39758.1 55 NDFNLEGIKSL 65
                99999999998 PP

  == domain 3  score: -1.2 bits;  conditional E-value: 0.83
       LRR_6  4 hLteLdLsgNdIgD 17
                ++t L +  N+Ig 
  EFC39758.1 70 NITNLGIGPNKIGT 83
                56778888899985 PP

  == domain 4  score: 12.2 bits;  conditional E-value: 4.3e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+LdL++N I+ eGa+ +
  EFC39758.1  95 LTALDLRCNYITMEGAQYI 113
                 9***************987 PP

  == domain 5  score: 6.4 bits;  conditional E-value: 0.003
       LRR_6  12 gNdIgDeGaeaLa 24 
                  NdI+ eGa+ ++
  EFC39758.1 140 LNDITAEGAQLIS 152
                 7********9885 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.0017
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                 +Lt L++  N+I+  Ga+ +
  EFC39758.1 156 SLTFLSIGQNNISSLGAKFI 175
                 69**************9976 PP

  == domain 7  score: 16.9 bits;  conditional E-value: 1.3e-06
       LRR_6   3 thLteLdLsgNdIgDeGaeaLa 24 
                 ++L++Ld+  N I+ eG++a++
  EFC39758.1 180 RNLRTLDIHNNTIDLEGVQAIC 201
                 79*******************8 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.1      0.34   1.2e+03      23      33 ..       2      12 ..       1      18 [. 0.70
   2 !   15.1   1.1   6.5e-06     0.023       2      39 ..      22      57 ..      21      65 .. 0.68
   3 !    8.2   0.3   0.00096       3.4       2      36 ..      46      81 ..      46      90 .. 0.83
   4 !    8.9   0.0   0.00057         2       2      37 ..      70     106 ..      69     109 .. 0.76
   5 ?    4.6   0.1     0.013        46       2      30 ..      94     124 ..      93     129 .. 0.60
   6 !   29.7   0.7   1.7e-10     6e-07       2      41 ..     156     196 ..     155     199 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.34
                TT--EEE-.-S CS
       LRR_4 23 pnLkeLdLsgN 33
                 nL+ Ld+ +N
  EFC39758.1  2 RNLTGLDICFN 12
                68888887454 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 6.5e-06
                S--EEE--SS---E-S-..HHH-TT--EEE-.-S-----G CS
       LRR_4  2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdl 39
                +L+ Ld+s N +       +++++nL++L +  N    d+
  EFC39758.1 22 QLIALDISFNSIDNNRIkiISGMKNLTKLRCFAN----DF 57
                5888999976766666664445*********334....33 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00096
                S--EEE--..SS---E-S-HHH-TT--EEE-.-.S--- CS
       LRR_4  2 nLevLdLs..nNqltdiplleklpnLkeLdLsg.Nnli 36
                nL++L ++  + +l  i +l +++n + L + g N +i
  EFC39758.1 46 NLTKLRCFanDFNLEGIKSLVSMKNITNLGI-GpN-KI 81
                89******85478999999999*******99.546.55 PP

  == domain 4  score: 8.9 bits;  conditional E-value: 0.00057
                 S--EEE--.SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLs.nNqltdipl..leklpnLkeLdLsgNnlit 37 
                 n ++L ++ n ++ + +   l+ +++L+ LdL ++n+it
  EFC39758.1  70 NITNLGIGpN-KIGTAETkaLSEMKQLTALDL-RCNYIT 106
                 5556666634.888877877677*********.999995 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.013
                 S--EEE--SS---E-S-..HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdL 30 
                 +L+ LdL+ N +t  +   ++ l nL eL +
  EFC39758.1  94 QLTALDLRCNYITMEGAqyISELHNLPELFI 124
                 6888888888888433344223666666666 PP

  == domain 6  score: 29.7 bits;  conditional E-value: 1.7e-10
                 S--EEE--SS---E-S-..HHH.-TT--EEE-.-S-----GGG CS
       LRR_4   2 nLevLdLsnNqltdipl..lek.lpnLkeLdLsgNnlitdlde 41 
                 +L++L++++N++++++   +++ l nL++Ld+ +Nn i dl++
  EFC39758.1 156 SLTFLSIGQNNISSLGAkfIGNgLRNLRTLDI-HNNTI-DLEG 196
                 7*****************75555*********.88888.8765 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.4   0.7   0.00048       1.7      24      55 ..      20      51 ..       2      57 .. 0.71
   2 !   19.5   0.0   1.7e-07   0.00061       2      56 ..      70     124 ..      63     127 .. 0.90
   3 !   21.4   0.6   4.3e-08   0.00016       2      38 ..     156     193 ..     140     203 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.4 bits;  conditional E-value: 0.00048
                -TT--EEE--SS---GGGGGGGTT--S-.EEE CS
       LRR_8 24 lsnLkvLdLsnNllttlspgafsgLpsLrsLd 55
                + +L  Ld+s N+++  + + +sg+++L++L 
  EFC39758.1 20 MDQLIALDISFNSIDNNRIKIISGMKNLTKLR 51
                56677777777777777777777777777775 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 1.7e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdL 56 
                 n t+L +  N++   + +a + +++L+ LdL++N +t   ++ +s L++L +L +
  EFC39758.1  70 NITNLGIGPNKIGTAETKALSEMKQLTALDLRCNYITMEGAQYISELHNLPELFI 124
                 789999999***************************9999999999999988876 PP

  == domain 3  score: 21.4 bits;  conditional E-value: 4.3e-08
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNllt 38 
                 +Lt L++  N+++sl+ ++  + l+nL++Ld+ nN+++
  EFC39758.1 156 SLTFLSIGQNNISSLGAKFIGNgLRNLRTLDIHNNTID 193
                 57889999999999999999888999999999999886 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   2.6     0.093   3.3e+02       2      12 ..      23      33 ..       3      65 .. 0.69
   2 ?    3.7   0.0     0.039   1.4e+02       2      21 ..      95     114 ..      94     124 .. 0.78
   3 ?    3.4   0.1     0.049   1.8e+02       1      19 [.     156     174 ..     156     177 .. 0.82
   4 ?    8.0   0.1    0.0015       5.3       1      21 [.     181     201 ..     181     203 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.093
       LRR_1  2 LrhLdLsnnpl 12
                L  Ld+s n++
  EFC39758.1 23 LIALDISFNSI 33
                44455555554 PP

  == domain 2  score: 3.7 bits;  conditional E-value: 0.039
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ LdL+ n ++  ++++++
  EFC39758.1  95 LTALDLRCNYITMEGAQYIS 114
                 999******99666655554 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.049
       LRR_1   1 nLrhLdLsnnpllglppns 19 
                 +L+ L +++n++++l++  
  EFC39758.1 156 SLTFLSIGQNNISSLGAKF 174
                 6999*******99888765 PP

  == domain 4  score: 8.0 bits;  conditional E-value: 0.0015
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 nLr+Ld+ nn ++  + ++++
  EFC39758.1 181 NLRTLDIHNNTIDLEGVQAIC 201
                 8*********98655555555 PP

>> Stn1_C  Telomere capping C-terminal wHTH
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.1    0.0061        22      48      81 ..      43      76 ..      22      77 .. 0.82
   2 ?    3.6   0.0     0.016        59      50      89 ..      95     135 ..      85     153 .. 0.81
   3 ?   -1.9   0.0      0.87   3.1e+03      55      71 ..     185     201 ..     172     204 .. 0.53

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0061
      Stn1_C 48 risvlikLqcltgtidykqireklklpelskkli 81
                 ++ l+kL+c +   +++ i++ ++++++++  i
  EFC39758.1 43 GMKNLTKLRCFANDFNLEGIKSLVSMKNITNLGI 76
                5678999******************999998765 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.016
      Stn1_C  50 svlikLqcltgtid.ykqireklklpelskkliidvfkesl 89 
                  + + L+c+ +t++  ++i e  +lpel  + i  v+ke +
  EFC39758.1  95 LTALDLRCNYITMEgAQYISELHNLPELFINQIPLVVKEPI 135
                 56789999999998456799999999999999999999865 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.87
      Stn1_C  55 Lqcltgtidykqirekl 71 
                 L +   tid++ ++ ++
  EFC39758.1 185 LDIHNNTIDLEGVQAIC 201
                 33444444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       411  (0.0229238); expected 358.6 (0.02)
Passed bias filter:                      330  (0.0184059); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.54u 0.30s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 1263.49
//
Query:       EFC39759.1  [L=412]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    0.00038   20.7  11.1    0.00038   20.7  11.1    5.1  5  Tup_N           Tup N-terminal
     0.0059   16.7  44.8      0.038   14.1   4.9    4.8  5  Cnn_1N          Centrosomin N-terminal motif 1
  ------ inclusion threshold ------
       0.27   11.1  20.0        1.2    9.0  11.0    2.8  2  Vip3A_N         Vegetative insecticide protein 3A N terminal
        3.8    7.5  53.5       0.59   10.1   6.2    3.3  3  CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein C
        9.9    6.2  51.9        3.7    7.6  14.0    3.1  3  UPF0242         Uncharacterised protein family (UPF0242) N-te


Domain annotation for each model (and alignments):
>> Tup_N  Tup N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   3.2      0.76   2.7e+03      10      25 ..      99     114 ..      78     143 .. 0.57
   2 ?    1.3   0.6      0.12   4.2e+02       6      43 ..     137     170 ..     129     194 .. 0.78
   3 !   20.7  11.1   1.1e-07   0.00038      15      74 ..     203     262 ..     190     265 .. 0.90
   4 !    6.8   1.6    0.0024       8.5      37      76 ..     267     308 ..     260     309 .. 0.82
   5 ?    0.9   0.4      0.16   5.8e+02      33      64 ..     329     360 ..     310     367 .. 0.69

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 0.76
       Tup_N  10 kqEfdalsqeasslka 25 
                 k+E ++  +e++++k+
  EFC39759.1  99 KKEMKQKDEEIEKIKM 114
                 3333333333333322 PP

  == domain 2  score: 1.3 bits;  conditional E-value: 0.12
       Tup_N   6 LdavkqEfdalsqeasslkaqkdeyelkiqsqiqElqq 43 
                 L  vk E d+  +++ +l+ + +e+++++++    + +
  EFC39759.1 137 LSSVKYENDSTVKKNVKLECKIEELDHSMTE----MIK 170
                 7788899999999999999999999987664....444 PP

  == domain 3  score: 20.7 bits;  conditional E-value: 1.1e-07
       Tup_N  15 alsqeasslkaqkdeyelkiqsqiqElqqirqtlyeLeeahrkikqqYEeeiarLkaeLe 74 
                 +   e+++l+ + + + +k++++++El+++ + + +L+++  k k++YE  i++L++e +
  EFC39759.1 203 KQLLENQQLDVKSQQLQNKVKQNLKELAKLTNLVSQLQMESVKSKKEYESSIQKLREEYK 262
                 55568889999999******************************************9965 PP

  == domain 4  score: 6.8 bits;  conditional E-value: 0.0024
       Tup_N  37 qiqElqq..irqtlyeLeeahrkikqqYEeeiarLkaeLesr 76 
                 +++E+qq  + q+  + +   +k k  YE +i  Lk+eL++ 
  EFC39759.1 267 KVSEMQQsfLPQHYVDTDDDLTKQKVFYETQIISLKKELKQL 308
                 4677776556788889999999*****************985 PP

  == domain 5  score: 0.9 bits;  conditional E-value: 0.16
       Tup_N  33 kiqsqiqElqqirqtlyeLeeahrkikqqYEe 64 
                  ++    E+ ++++ +  L+ +  ++k q  e
  EFC39759.1 329 TLSDRNGEISKLKSVVISLNDQLAELKSQLAE 360
                 46667778888888888888888888887643 PP

>> Cnn_1N  Centrosomin N-terminal motif 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.2      0.13   4.7e+02      48      65 ..      91     108 ..      82     109 .. 0.82
   2 !   13.8  10.2   1.3e-05     0.047       3      62 ..     103     168 ..     100     177 .. 0.91
   3 ?    1.2   5.9      0.11     4e+02      36      69 ..     200     232 ..     176     239 .. 0.76
   4 !   14.1   4.9   1.1e-05     0.038       3      67 ..     248     313 ..     246     318 .. 0.90
   5 !    4.7   1.0    0.0096        35      36      62 ..     335     361 ..     312     370 .. 0.51

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.13
      Cnn_1N  48 lkveveslqkelkekkkl 65 
                 +k +ve+ +ke+k+k+++
  EFC39759.1  91 MKSDVEHVKKEMKQKDEE 108
                 689999999999999986 PP

  == domain 2  score: 13.8 bits;  conditional E-value: 1.3e-05
      Cnn_1N   3 rEqeeqidkLkKENFdLKLriyfLeerleklse......eqkeellkenielkveveslqkelkek 62 
                 +  +e+i+k+k EN  L+ ri +++ rl++++        ++++++k+n++l+ ++e+l +++ e+
  EFC39759.1 103 KQKDEEIEKIKMENLVLRTRIEEMQIRLTENERnlssvkYENDSTVKKNVKLECKIEELDHSMTEM 168
                 66789**************************999*****9*******************9998776 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.11
      Cnn_1N  36 eqkeellkenielkveveslqkelkekkkllrea 69 
                   k++ll en +l v+ ++lq+++k+  k+l ++
  EFC39759.1 200 LYKKQLL-ENQQLDVKSQQLQNKVKQNLKELAKL 232
                 4455555.5**************99999988876 PP

  == domain 4  score: 14.1 bits;  conditional E-value: 1.1e-05
      Cnn_1N   3 rEqeeqidkLkKENFdLKLriyfLeer.leklseeqkeellkenielkveveslqkelkekkkllr 67 
                 +E+e++i+kL+ E  +   ++ ++++  l +   ++ ++l k+ +  ++++ sl+kelk+++++ +
  EFC39759.1 248 KEYESSIQKLREEYKNQLGKVSEMQQSfLPQHYVDTDDDLTKQKVFYETQIISLKKELKQLQDRYE 313
                 9*************************95566666***************************98765 PP

  == domain 5  score: 4.7 bits;  conditional E-value: 0.0096
      Cnn_1N  36 eqkeellkenielkveveslqkelkek 62 
                  ++ +l +  i l +++++l+ +l e 
  EFC39759.1 335 GEISKLKSVVISLNDQLAELKSQLAES 361
                 444455555555555555555555554 PP

>> Vip3A_N  Vegetative insecticide protein 3A N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2   0.7    0.0012       4.2     103     155 ..      70     122 ..      63     151 .. 0.81
   2 ?    9.0  11.0   0.00034       1.2      35     143 ..     200     313 ..     164     327 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0012
     Vip3A_N 103 lrvylpkitsmlsdvmkqnyalslqieylskqlqeisdkldiinvnvlinstl 155
                 l  +  +it  lsd  k +y +  ++e++ k++++  + ++ i+++ l+  t 
  EFC39759.1  70 LDNFQGRITKYLSDNEKVKYLMKSDVEHVKKEMKQKDEEIEKIKMENLVLRTR 122
                 5667789***************************9999999999877765553 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00034
     Vip3A_N  35 ltldeilknqqllndisgkldgvngslndliaqgnlntelskeilkianeqn....qvlndvnnkldaintmlrvylpki.tsmlsdvmkqnyalslqi 128
                 l   ++l nqql  +  +  + v+ +l++l    nl ++l  e +k  +e +    ++ ++ +n+l  +  m + +lp+      +d+ kq+     qi
  EFC39759.1 200 LYKKQLLENQQLDVKSQQLQNKVKQNLKELAKLTNLVSQLQMESVKSKKEYEssiqKLREEYKNQLGKVSEMQQSFLPQHyVDTDDDLTKQKVFYETQI 298
                 444567888887666666667899999999999999999999999988886511214556789***************86156778899********** PP

     Vip3A_N 129 eylskqlqeisdkld 143
                   l k+l+++ d+ +
  EFC39759.1 299 ISLKKELKQLQDRYE 313
                 **********99875 PP

>> CENP-F_leu_zip  Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1  15.4   0.00073       2.6      29     105 ..      91     167 ..      79     173 .. 0.89
   2 ?    0.1  17.4      0.21   7.4e+02      55     137 ..     177     263 ..     166     266 .. 0.82
   3 ?   10.1   6.2   0.00017      0.59      57     122 ..     294     363 ..     268     375 .. 0.79

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00073
  CENP-F_leu_zip  29 LerelemseenqekvileaEtskaevetlkeeieelaeelreleldLvalrsekeeLekelqkkqervseLeslnss 105
                     +++++e ++++  +   e E+ k+e   l++ iee++ +l+e e +L++++ e+++  k+  k   +++eL+ +  +
      EFC39759.1  91 MKSDVEHVKKEMKQKDEEIEKIKMENLVLRTRIEEMQIRLTENERNLSSVKYENDSTVKKNVKLECKIEELDHSMTE 167
                     6789999999999999999999999999*******************************************988665 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.21
  CENP-F_leu_zip  55 etlkeeieelaeelreleldLvalr....sekeeLekelqkkqervseLeslnsslenlleekEqekvqmkeeskaaveeLqtqlke 137
                      +l ++   l +el+e e  + +l      e+++L+ + q+ q++v++  +   +l+nl++++ +e v+ k+e+++++++L+ + k+
      EFC39759.1 177 HSLTDQFSILCKELTEREGSIMELYkkqlLENQQLDVKSQQLQNKVKQNLKELAKLTNLVSQLQMESVKSKKEYESSIQKLREEYKN 263
                     56677777777777777777776664555699**************987777789***************************99886 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.00017
  CENP-F_leu_zip  57 lkeeieelaeelreleldLvalr....sekeeLekelqkkqervseLeslnsslenlleekEqekvqmke 122
                      +++i  l++el++l+   ++ r    + +e+L + l + + ++s L+s+  sl+ +l e+  + ++ ++
      EFC39759.1 294 YETQIISLKKELKQLQDRYETQRklsnESNETLLRTLSDRNGEISKLKSVVISLNDQLAELKSQLAESRQ 363
                     47899999999999999999988787788999************************99998777444443 PP

>> UPF0242  Uncharacterised protein family (UPF0242) N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6  14.0     0.001       3.7      74     177 ..      92     202 ..      65     204 .. 0.75
   2 ?    5.2  16.6    0.0055        20      87     163 ..     202     280 ..     188     286 .. 0.84
   3 ?    4.1   9.0     0.013        46      75     152 ..     291     366 ..     282     374 .. 0.70

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.001
     UPF0242  74 eaklteldeglktkeealeelqeeeeeLkeeldakeeelerlkeenqqLqekleaiae.......dfeelkleleeqLaekqellqeyqetieeqrsvl 165
                 ++ +   ++++k+k+e++e+ + e+  L+ ++++++  l + +++  +++ +   +++        +eel   + e ++ k   ++ +  +++ + ++l
  EFC39759.1  92 KSDVEHVKKEMKQKDEEIEKIKMENLVLRTRIEEMQIRLTENERNLSSVKYENDSTVKknvklecKIEELDHSMTEMIKMKDSVIHSLTDQFSILCKEL 190
                 2233333367899999999999999999999888888888888877788777777777777787799******************************** PP

     UPF0242 166 ekrqdqieqLes 177
                  +r+  i +L  
  EFC39759.1 191 TEREGSIMELYK 202
                 ***999999865 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.0055
     UPF0242  87 keealeelq..eeeeeLkeeldakeeelerlkeenqqLqekleaiaedfeelkleleeqLaekqellqeyqetieeqrs 163
                 k++ le+ q   + ++L++++++  +el++l++   qLq++  ++++++e + ++l e+ +++  +++e+q+++  q+ 
  EFC39759.1 202 KKQLLENQQldVKSQQLQNKVKQNLKELAKLTNLVSQLQMESVKSKKEYESSIQKLREEYKNQLGKVSEMQQSFLPQHY 280
                 4556666652258899**********************************************************99985 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.013
     UPF0242  75 aklteldeglktkeealeelqeeeee.LkeeldakeeelerlkeenqqLqekleaiaedfeelkleleeqLaekqellq 152
                 ++  e++  +   +++l++lq++ e  +k   ++ e++l+ l  +n +++ kl+ ++   ++++ el++qLae ++l +
  EFC39759.1 291 KVFYETQ--IISLKKELKQLQDRYETqRKLSNESNETLLRTLSDRNGEIS-KLKSVVISLNDQLAELKSQLAESRQLKK 366
                 4444444..44555566666665443033334566788888999999998.9999999999**********99888765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (412 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3592  (0.200346); expected 358.6 (0.02)
Passed bias filter:                      556  (0.0310112); expected 358.6 (0.02)
Passed Vit filter:                       111  (0.00619109); expected 17.9 (0.001)
Passed Fwd filter:                        53  (0.0029561); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.21u 0.35s 00:00:01.56 Elapsed: 00:00:00.58
# Mc/sec: 2139.76
//
Query:       EFC39760.1  [L=768]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-25   88.6   0.1    7.8e-25   87.3   0.1    1.8  1  DUF547    Protein of unknown function, DUF547
  ------ inclusion threshold ------
      0.061   13.9   0.1       0.29   11.7   0.1    2.2  1  QIL1      MICOS complex subunit MIC13, QIL1
      0.081   13.2  16.6      0.047   14.0  10.1    3.7  3  RGS       Regulator of G protein signaling domain
       0.23   11.2   8.6        2.2    8.1   8.2    2.5  2  DUF285    Mycoplasma protein of unknown function, DUF285
       0.53   10.9   5.1        1.4    9.5   0.0    3.3  4  LuxT_C    Tetracycline repressor LuxT C-terminal domain


Domain annotation for each model (and alignments):
>> DUF547  Protein of unknown function, DUF547
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   87.3   0.1   2.2e-28   7.8e-25       5     122 ..     382     507 ..     378     508 .. 0.91

  Alignments for each domain:
  == domain 1  score: 87.3 bits;  conditional E-value: 2.2e-28
      DUF547   5 s.reeklAfwiNlYNalvlhaileyg..pesnvkrlslfkkaayniggqslslddIehgiLrkn.....lsrlkkkarderrkyaleqpdprihfaLvc 95 
                 + +eekl f+iN+YN+l+lha+l  g  p+ +v +  +++k +yn+ggq++sl+dI +giL++n     ++ ++ k++d+r++ + ++  p ++f L +
  EFC39760.1 382 KsDEEKLTFFINAYNLLLLHALLVSGsmPQVEVTNIIFYRKVRYNLGGQEYSLQDIFNGILQCNqmkclIYGKAFKKNDARKANIPNKTFPEVYFGLIN 480
                 5499*******************9999988889999999*************************77776444444559********************* PP

      DUF547  96 gsascpplriytaerleeqLeaaaeeF 122
                  ++ +p+lriy++ +l ++L+++++++
  EFC39760.1 481 MTKYSPKLRIYEPTSLLDKLKENTKDY 507
                 *************************99 PP

>> QIL1  MICOS complex subunit MIC13, QIL1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   8.1e-05      0.29      16      73 ..     496     561 ..     492     564 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 8.1e-05
        QIL1  16 lykkakeyipPyvdevkkklcle.......vpklpsveevkf.slveyWNkgVkkvfsflselPty 73 
                 l+ k+ke+ + y+d++ + l+++        + lps+ +  + +l++ W++ V++v++++++l t+
  EFC39760.1 496 LLDKLKENTKDYFDRYVQVLPSDqhptellEIALPSQLKEHKcELKNFWKSDVTTVIKTVNNLSTA 561
                 5667777777777766555555456666888888888766665*******************9875 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0  10.1   1.3e-05     0.047       1     113 [.      52     254 ..      52     260 .. 0.88
   2 ?   -3.5   0.1       3.3   1.2e+04      61     100 ..     334     373 ..     329     377 .. 0.63
   3 ?   -2.8   0.0       2.1   7.4e+03      53      77 ..     451     475 ..     439     513 .. 0.64

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.3e-05
                 -HHHHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS.....................................................SHHHHH CS
         RGS   1 sleslledqpgrslFreFlesefseenlsFwlaveefkka.....................................................keqeel 46 
                 s+e++l+ + g+s+F +Fl +ef++en+  + + + +                                                        +e +e 
  EFC39760.1  52 SVENILSCPLGVSYFYKFLSEEFNKENILAYYELKSLIDYllyskkkmdwvidtsdvyrddisdvssissanssfisntnseqsikyvnttsvDEIREC 150
                 5789************************999999999888999***********************************************888888888 PP

                 HHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS......................................STTTTTTHHHHHHHHHHHHHHHHH CS
         RGS  47 kkkakeIyneylapsspkelnidkklreelekrleke......................................qpsrklfeeaqeevfellekdsyp 107
                  k++++  ++y++ ss  e+ni++ +++++ + ++                                        ++ ++++ee+++  +  l +d+++
  EFC39760.1 151 FKRIQQFKKTYFDASSLFEINISSTMKKKVLESISFTkevqdfishtqktdddsistnscsqmieetlnkmhsnlEKIQTVLEELKTDLLHNL-SDPFQ 248
                 888999999*********************999987778899999999999999999999999999997777766666667777777776666.48899 PP

                 HHHTSH CS
         RGS 108 kFlkse 113
                 +F++s+
  EFC39760.1 249 RFMSSD 254
                 998886 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 3.3
                 TSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHHHHHHHHHH CS
         RGS  61 sspkelnidkklreelekrlekeqpsrklfeeaqeevfel 100
                 + ++e n +++++e   + l k++++ + +e+ q+e+f+l
  EFC39760.1 334 KTSCESNESEAVVELNFDDLGKSETCCNKYEKFQHETFDL 373
                 5556666666666666666666677777777777777765 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 2.1
                 HHHHHTSTTSTTSSTS-HHHHHHHH CS
         RGS  53 Iyneylapsspkelnidkklreele 77 
                 Iy + ++++ +++ ni++k++ e+ 
  EFC39760.1 451 IYGKAFKKNDARKANIPNKTFPEVY 475
                 7777777777788888888776664 PP

>> DUF285  Mycoplasma protein of unknown function, DUF285
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   8.2   0.00061       2.2      21      95 ..     114     192 ..      92     227 .. 0.65
   2 ?    0.4   0.2      0.14   5.1e+02      16      60 ..     203     249 ..     188     254 .. 0.66

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00061
      DUF285  21 wdtskvtdmssmFegakkfnqdiskwdtssVtnmssmFkeatsfnq...diss.WdtsnvtnmssmFkeaksfnqdiss 95 
                  d+s++ + +s F ++++ +q+i+  +t sV ++++ Fk+ ++f++   d ss ++++  ++m++   e  sf++++++
  EFC39760.1 114 SDVSSISSANSSFISNTNSEQSIKYVNTTSVDEIRECFKRIQQFKKtyfDASSlFEINISSTMKKKVLESISFTKEVQD 192
                 3677777777778888888888888888888888888877777666444333334444445555555555555555544 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.14
      DUF285  16 qdiskwdtskv..tdmssmFegakkfnqdiskwdtssVtnmssmFke 60 
                 ++is+   s++  +++++m ++ +k+++ +++ +t+   n+s+ F++
  EFC39760.1 203 DSISTNSCSQMieETLNKMHSNLEKIQTVLEELKTDLLHNLSDPFQR 249
                 55555555544223578888888888888888888888888877765 PP

>> LuxT_C  Tetracycline repressor LuxT C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.0         2   7.1e+03      23      46 ..     125     132 ..     112     162 .. 0.54
   2 ?    2.1   0.2     0.078   2.8e+02      26      68 ..     179     221 ..     152     228 .. 0.75
   3 ?    9.5   0.0    0.0004       1.4       6      56 ..     229     279 ..     226     283 .. 0.89
   4 ?   -3.4   0.0       4.2   1.5e+04      12      41 ..     579     609 ..     577     613 .. 0.66

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 2
      LuxT_C  23 SWvealeqaefkavlrlllslvss 46 
                 S++                s+++s
  EFC39760.1 125 SFI----------------SNTNS 132
                 333................33333 PP

  == domain 2  score: 2.1 bits;  conditional E-value: 0.078
      LuxT_C  26 ealeqaefkavlrlllslvssseqaeektaqalnklrelavek 68 
                 ++le+  f   ++ ++s+++++++ +  t  +++ ++e + ++
  EFC39760.1 179 KVLESISFTKEVQDFISHTQKTDDDSISTNSCSQMIEETLNKM 221
                 56888889999999*******8888888888888887776444 PP

  == domain 3  score: 9.5 bits;  conditional E-value: 0.0004
      LuxT_C   6 elvleqLDfssadaleeSWvealeqaefkavlrlllslvssseqaeektaq 56 
                 ++vle+L +  +++l+  ++ +++++e+  ++ l+ls+ ++++  +e + +
  EFC39760.1 229 QTVLEELKTDLLHNLSDPFQRFMSSDEMYECMALFLSSQGDDTYHRERVLN 279
                 789******99***************************9997777766655 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 4.2
      LuxT_C  12 LDfssadaleeSW.vealeqaefkavlrlll 41 
                 +D ss+++++ S  +++ e +  k+vl +l+
  EFC39760.1 579 IDSSSLSDVSTSRsITSAEADIRKNVLDYLM 609
                 7888877777663256666677778887776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (768 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1556  (0.0867868); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.48
# Mc/sec: 4829.43
//
Query:       EFC39761.1  [L=451]
Description: beta-tubulin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.5e-70  235.4   0.0    1.2e-69  234.4   0.0    1.5  1  Tubulin          Tubulin/FtsZ family, GTPase domain
    3.6e-41  140.3   0.1    5.5e-41  139.7   0.1    1.3  1  Tubulin_C        Tubulin C-terminal domain
    3.6e-05   24.1   0.0    9.8e-05   22.6   0.0    1.7  1  Misat_Tub_SegII  Misato Segment II tubulin-like domain
    0.00063   19.0   0.0     0.0029   16.9   0.0    1.9  2  Tubulin_2        Tubulin like
     0.0011   18.6   0.0     0.0022   17.7   0.0    1.5  1  Tubulin_3        Tubulin domain


Domain annotation for each model (and alignments):
>> Tubulin  Tubulin/FtsZ family, GTPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  234.4   0.0   3.4e-73   1.2e-69       1     196 [.       3     211 ..       3     212 .. 0.99

  Alignments for each domain:
  == domain 1  score: 234.4 bits;  conditional E-value: 3.4e-73
                 EEEEEEEHHHHHHHHHHHHH...HHHCH..............HHHT.....TTEEEEE....EEESBHHHHHTS-GS........EEEE--CCCCTTC- CS
     Tubulin   1 eiivigvGqcGnqignelwellakehgiqsdg..........dslesfFsesgkveyiprsvaidtdpqvlneikags..elfnpnklllgkegagnng 87 
                 ei++i+ GqcGnqig ++we++ +ehg++++g          ++++++++e   ++y+pr++++d++p ++++++ag+  ++f+p+++++g++gagnn+
  EFC39761.1   3 EIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGayhgdsdlqlERINVYYNEATGGRYVPRAILMDLEPGTMDSVRAGPygQIFRPDNFVFGQTGAGNNW 101
                 79**************************98889******************999********************************************* PP

                 -TT-HHHHHHHHHHTHHHHHHHHTT-SE.SEEEEEEETTSSHHHHHHHHHHHHHHHTSTTSEEEEEEEE--.GG.G-HHHHHHHHHHHHHHHHT-SEEE CS
     Tubulin  88 aggypevgkeaaeeileeirkevekcdslqgffitaslgGGTGSGlgpvilevlkeeypkalvvtvvvlPs.efsevvvepynailalkelieesdavi 185
                 a+g+++ g+e+++++l+ +rke+e+cd+lqgf+i +slgGGTGSG+g++++++++eeyp+++++t++v+Ps + s+ vvepyna l++++l+e++d v+
  EFC39761.1 102 AKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVFPSpKVSDTVVEPYNATLSVHQLVENADEVM 200
                 *************************************************************************************************** PP

                 EEEHHHHHCCS CS
     Tubulin 186 vidNdaLlkil 196
                 +idN+aL++i+
  EFC39761.1 201 CIDNEALYDIC 211
                 **********8 PP

>> Tubulin_C  Tubulin C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  139.7   0.1   1.5e-44   5.5e-41       1     125 [.     261     382 ..     261     383 .. 0.99

  Alignments for each domain:
  == domain 1  score: 139.7 bits;  conditional E-value: 1.5e-44
                 TTC-EEEEEEESSSCTTTTTCS-HHHHHHHHHTCSGGGBSSSTSTTTSSEEEEEEEEEESSSHHHHHHHHHHHHHTTTS-BSTTSTTTEEEEEEECECT CS
   Tubulin_C   1 PrlhFlltsyaPlvsaekaavektsvqdvtrallepknimvkvdprkgkylaiallirGdvepkevnkavqrikekkkaqfveWiptgikvalnkkspy 99 
                 PrlhF+l+++aPl+s+ +++++ ++v ++t++++++kn+m+++dpr+g+yl++++++rG++++kev++++ ++++k++++fveWip++ik ++++ +p 
  EFC39761.1 261 PRLHFFLIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAASDPRHGRYLTASAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDIPPR 359
                 9************************************************************************************************** PP

                 -TTTSSCEEEEEEEEGGGHHHHHHHH CS
   Tubulin_C 100 vkkqskvsvlmlaNttsiaelfkrll 125
                 + k+    +++++N+t+i+e+fkr++
  EFC39761.1 360 GLKMA---ATFIGNSTAIQEMFKRVS 382
                 **999...****************86 PP

>> Misat_Tub_SegII  Misato Segment II tubulin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.0   2.7e-08   9.8e-05       1      68 [.       2      71 ..       2      87 .. 0.76

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 2.7e-08
  Misat_Tub_SegII  1 rEivtlqlGnyaNyvgtHfWNtQesyftydeeeeesevdhdvlfre...getkqgqvtytPRllivDlkgs 68
                     rEiv +q G+  N +g+ fW +  +    d++    + d+d++       +++ +   y+PR++++Dl+ +
       EFC39761.1  2 REIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGA-YHGDSDLQLERinvYYNEATGGRYVPRAILMDLEPG 71
                     8********************9998887788777.45555555433111223566789*********9754 PP

>> Tubulin_2  Tubulin like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.9   0.0     8e-07    0.0029     138     203 ..     112     176 ..      97     194 .. 0.78
   2 ?   -0.7   0.0      0.18   6.4e+02      53     104 ..     302     348 ..     248     354 .. 0.72

  Alignments for each domain:
  == domain 1  score: 16.9 bits;  conditional E-value: 8e-07
   Tubulin_2 138 alrdaikrlrgsage.eeglnvfVvgSLaGGTGSGiflDvayllrkilkeekqkvkiiglvllPdvf 203
                  ++++++ +r++a++ + +  + ++ SL GGTGSG+   ++  +r+++++      ++ ++++P+v 
  EFC39761.1 112 LIDSVLDVVRKEAEScDCLQGFQIAHSLGGGTGSGMGTLLISKIREEYPDRMM--MTFSVFPSPKVS 176
                 566666666665555555566789**************************997..589999999985 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.18
   Tubulin_2  53 detaekageslksrekealsissaevdr.ilrnllreetasaypsieeWlppe 104
                 ++ + + g++l++++++   +s +evd+ +l+ +      +++++  eW+p++
  EFC39761.1 302 ASDP-RHGRYLTASAMFRGRMSTKEVDEqMLNVQN-----KNSSYFVEWIPNN 348
                 2233.567788888888889999999751555553.....3344677999765 PP

>> Tubulin_3  Tubulin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   6.2e-07    0.0022      64     148 ..     120     198 ..     102     238 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 6.2e-07
   Tubulin_3  64 lrpfaeecdqlrglqvftgvddaWG.GfaakylerlrdeygkksilvWvlaleeklkkkkkaklerklkklnkarslkelseqasl 148
                 +r+ ae cd l+g+q+  +     G G ++  + ++r+ey+ + ++++ +   +++ +      +  ++  n + s+++l e+a  
  EFC39761.1 120 VRKEAESCDCLQGFQIAHSLGGGTGsGMGTLLISKIREEYPDRMMMTFSVFP-SPKVS------DTVVEPYNATLSVHQLVENADE 198
                 6999***************99887769***************9987776533.22222......1223445555566666555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (451 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       533  (0.0297284); expected 358.6 (0.02)
Passed bias filter:                      445  (0.0248201); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.68u 0.34s 00:00:01.02 Elapsed: 00:00:00.57
# Mc/sec: 2384.81
//
Query:       EFC39762.1  [L=666]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-16   59.2   1.3    1.4e-15   57.6   1.3    1.9  1  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   57.6   1.3   7.5e-20   1.4e-15      12     115 ..     141     250 ..     136     253 .. 0.94

  Alignments for each domain:
  == domain 1  score: 57.6 bits;  conditional E-value: 7.5e-20
                 HHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTST..TSSTS-HHHHHHHHHHHCSS....STTTTTTHHHHHHHHHHHHHH CS
         RGS  12 rslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapssp..kelnidkklreelekrleke....qpsrklfeeaqeevfellekd 104
                 +++FreFl+ e ++  l+F++ + ++++ ++++e+ ++ak I+++++++s +  k+ln++++l++++ +++e+e    ++  +lf++a +ev   l++d
  EFC39762.1 141 LEAFREFLQYERNSAPLEFLQLIPTYREISNSNERYQQAKYIVETFVDDSLTsdKQLNLPNALKDQIVNQFEDEctpsNTPTNLFDQAMTEVTISLKTD 239
                 689********************************************9986544999*******************999999***************** PP

                 HHHHHHTSHHH CS
         RGS 105 sypkFlksely 115
                 s+++F++s+ +
  EFC39762.1 240 SFSRFITSNQF 250
                 ********998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (666 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1179  (0.0657594); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.73u 0.34s 00:00:01.07 Elapsed: 00:00:00.53
# Mc/sec: 3796.48
//
Query:       EFC39763.1  [L=516]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.3e-78  263.2  10.7    5.5e-78  262.9  10.7    1.0  1  Serpin    Serpin (serine protease inhibitor)
  ------ inclusion threshold ------
        1.9    8.9   5.0        3.5    8.0   1.3    2.6  2  DHHA1     DHHA1 domain


Domain annotation for each model (and alignments):
>> Serpin  Serpin (serine protease inhibitor)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  262.9  10.7   6.1e-82   5.5e-78       5     369 ..     119     512 ..     116     514 .. 0.84

  Alignments for each domain:
  == domain 1  score: 262.9 bits;  conditional E-value: 6.1e-82
                 HHHHHHHHHHHHHSTTSSEEE-HHHHHHHHHHHHHTB-HHHHHHHHHHHTGCC............HCHHHHHHHHHHH.HHHHCS.......SGGTSEE CS
      Serpin   5 kfaldlfkalskekpskNiifSPlsistaLallllGakgetaeellevLglne............sdeeelhealekl.lsrlne.......seekdke 83 
                 +f+  lf        ++N+++SP+si++++  +  G+++e+ +e+ + L l++            +       ++e++  ++l++         +++++
  EFC39763.1 119 EFSSALFSIKVGL--KENVVMSPFSIFICFLNCMVGTNNESLTEIIDGLFLSKsydsvgnfntlkE-------KFENWkKTELEKytnmikiLIQTNDT 208
                 5666666544444..49********************************99887777744443331.......34444333333366666665568*** PP

                 EEEEEEEEEETTSEB-HHHHHHHHHHHS-EEEEE-TTTHHH.HHHHHHHHHHHHTTTSSSSSSSTTSS-TTECEEEEEEEEEEEEBSS--BGGGEEEEE CS
      Serpin  84 lkianglfvekglklkeeflklakklykaevesvdfkddee.arkkINswvekqTngkIkdllsegsidsdtrlvlvNaiyFkGkWeepFqpeatreek 181
                 l+ian++++++++++ke fl++++  +++++e vdf ++++  ++ IN+wve++T++ I+dlls+ +i+++t++vlvNaiyF+GkW+++F+ ++t +++
  EFC39763.1 209 LSIANRIYLQETVQIKEPFLQELESKFDSQAERVDFMNKPSaQVRLINKWVEDKTRKYIRDLLSDTDINRQTIMVLVNAIYFNGKWKYQFKNRSTFKKS 307
                 *************************************************************************************************** PP

                 EESSSSEEE..EEEEE..EEEEEEEEEEETTTTEEEEEEEBGG.SEEEEEEEESSTTT.HHHHHHHHSHHH...HHHHHHHGEEEEEEE.EEEEE-EEE CS
      Serpin 182 Fyvnegekv..kvpmM..sqegkfkyaedeelnakvlelpYkg.nlsmlillPdeekg.leelekkltaer...leewlsklkmkkeke.evslPkfki 270
                 F++ ++++   k +mM  s ++kf ya+ +  ++++l+lpY++ ++ m+++ P+e+ +  ee e+ +++     l+++++ + ++ +k  ++ +Pkfk+
  EFC39763.1 308 FRTISNPSGgdKCDMMhmSSDKKFCYANLD--EYQLLQLPYSDeDYCMTFIKPNENVTlNEETENDFNQWIiekLQDVTQLQPNTFVKVdRIEIPKFKF 404
                 **5444443348888833555888888877..9********776*********888886779999999655333666666666555555788******* PP

                 EEEE.EHHHHHHH..TTHCGGGSTTTB.BTTTBSS..SSEEEEEEEEEEEEEESSSEEEEEEEEE.....ECCTTCS-SSCEEEEECSEEEEEEEETTT CS
      Serpin 271 eesi.dlkevLqk..lGlkdlFseneadlsgiskk..eplfvsevlhkafievnEeGteaaaata.....vatllskksspvefkvdrPFlflireekt 359
                 + ++ +l + +++  +++k++Fs ++ad+s ++++  +++++s+v+hkafi+v+E Gt aaaata        +++k +++ +f++drPF+f++++ +t
  EFC39763.1 405 QATLpNLVQSFREdpFNIKNIFS-SQADFSSMLANsnDQVHISNVIHKAFIQVDESGTVAAAATAmggrgGGRAMKKFTPSYQFIADRPFVFILQHLPT 502
                 ***99******87568*******.*********55569******************************9637899************************ PP

                 TEEEEEEEES CS
      Serpin 360 gliLFlGkvv 369
                 ++iLF Gk++
  EFC39763.1 503 NTILFTGKIN 512
                 ********97 PP

>> DHHA1  DHHA1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.1     0.049   4.4e+02       7      76 ..     213     286 ..     210     305 .. 0.68
   2 ?    8.0   1.3   0.00039       3.5      92     116 ..     452     478 ..     405     479 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.049
                 HHHHHHHHHHCHHHHHHHHHHHHHHHTCEEEC..TCEEEEEECHCCHHHHHHHHHHHHHHTHG..BT.TCEEEEE CS
       DHHA1   7 erkelekeleelkealaklkaeellekaeevk..gvkvlvaevgeewdagalgiaadklkskl..kk.pvivfva 76 
                 +r  l++ ++ ++ +l++ +++++ ++ae+v+  +++ + +++ ++w  + ++ ++ +l+s    ++ ++ v+v 
  EFC39763.1 213 NRIYLQETVQIKEPFLQE-LESKFDSQAERVDfmNKPSAQVRLINKWVEDKTRKYIRDLLSDTdiNRqTIMVLVN 286
                 566677777645555555.56789999999999966666666668888888888888888844436634444443 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.00039
                 H..SS-HHHHHHHHHHHTTCCEEEETC CS
       DHHA1  92 d..gvdagelakeaaaklgggGGGHdl 116
                 +  +vd +  + +aa+++gg+GGG+++
  EFC39763.1 452 AfiQVDESGTVAAAATAMGGRGGGRAM 478
                 34445555555569***********87 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (516 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       994  (0.0554409); expected 358.6 (0.02)
Passed bias filter:                      469  (0.0261587); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.68u 0.29s 00:00:00.97 Elapsed: 00:00:00.49
# Mc/sec: 3141.72
//
Query:       EFC39764.1  [L=293]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1634  (0.0911373); expected 358.6 (0.02)
Passed bias filter:                      394  (0.0219756); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.54u 0.29s 00:00:00.83 Elapsed: 00:00:00.47
# Mc/sec: 1888.79
//
Query:       EFC39765.1  [L=1374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      5e-55  186.7   7.0    7.9e-55  186.0   7.0    1.3  1  Pkinase         Protein kinase domain
    2.6e-32  112.1   1.9    3.9e-32  111.6   1.9    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    5.2e-16   57.8   5.6    0.00026   20.9   0.0    7.6  7  NHL             NHL repeat
    5.1e-07   28.8   0.1    8.6e-07   28.1   0.1    1.2  1  Pkinase_fungal  Fungal protein kinase
     0.0044   16.6   1.3      0.011   15.3   1.3    1.6  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL
     0.0055   16.3   2.3      0.013   15.1   2.3    1.6  1  RIO1            RIO1 family
     0.0072   15.9   5.4      0.022   14.3   5.4    1.8  1  ComR_TPR        ComR tetratricopeptide
     0.0078   16.6   7.5      0.017   15.5   7.5    1.6  1  EGF_2           EGF-like domain
  ------ inclusion threshold ------
      0.071   12.4   0.3       0.12   11.7   0.3    1.4  1  Kinase-like     Kinase-like
      0.072   12.4   0.8       0.13   11.6   0.8    1.3  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
       0.28   11.5   3.9       0.82   10.0   3.9    1.8  1  EGF             EGF-like domain
        3.8    8.3   5.8         10    7.0   5.8    1.8  1  hEGF            Human growth factor-like EGF


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  186.0   7.0   5.3e-58   7.9e-55       1     264 []    1115    1373 ..    1115    1373 .. 0.91

  Alignments for each domain:
  == domain 1  score: 186.0 bits;  conditional E-value: 5.3e-58
                  EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEE.EE--TTEBHHHHHHHHSS-- CS
     Pkinase    1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylv.leyveggeladllerkgsls 96  
                  y++++++G+G+fG+Vyk+++ +++k  A+K +k e  ++ +  ++++E + l++++h+ni+++ ++f ++d+l+++ ++y e g+l++l ++  + s
  EFC39765.1 1115 YSNITRIGQGAFGSVYKVTDLKKNKLKAIKLVKFETLTDLN--TIMKEASQLNHINHSNIIKINDYFITNDNLLIIdMDYFELGDLTKLKQE--NCS 1207
                  678899*****************************999876..5***************************999666**********99985..89* PP

                  HHHHHHHHHHHHHHHHHHH.HTTEE-SS-SGGGEEEETTTE....EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHH CS
     Pkinase   97 eeeakkiakqilegleylH.skgiiHrDlKpeNiLidekge....lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvily 188 
                  e+ +k+i+kq+l++l+y+H +++iiHrD+K+ Ni+i++       + ++DFGlak++++ +  +s+ gt+ Y++PEv  +++ys ++D++slG+ +y
  EFC39765.1 1208 EKIVKQILKQMLNALKYVHeEMHIIHRDIKQTNIFIKKMTSdnidIVLADFGLAKKYQEMT-GQSYAGTPLYMSPEVALGSSYSYNTDIFSLGISIY 1303
                  *******************7788**************53334688**************98.9********************************** PP

                  HHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase  189 elltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264 
                  +++t+    s      ++  + +q e+ +kil++ ++k   + e s+e+++++ k+l+kd ++R++a++ll+ +y+
  EFC39765.1 1304 QIMTNDLATS-----ISNLLMGNQAENAIKILKN-QMKESAHCEYSDELIEIVLKMLEKDANQRPSASQLLSLKYF 1373
                  ******9999.....2334567777889999965.7888888889**************************99997 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.6   1.9   2.6e-35   3.9e-32       5     256 ..    1119    1368 ..    1115    1370 .. 0.83

  Alignments for each domain:
  == domain 1  score: 111.6 bits;  conditional E-value: 2.6e-35
                   EEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEE.EE--TTEBHHHHHHHTCTTT CS
  Pkinase_Tyr    5 kklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeeplliv.teyvkgGdLlkfLrkkekek 99  
                   +++G+GafG+V++ t      kk+   a+K +k e+  +  + +++ea+ +++++h ni+k+    + +++lli+ ++y + GdL k  +++   +
   EFC39765.1 1119 TRIGQGAFGSVYKVTDL----KKNKLKAIKLVKFETLTD-LNTIMKEASQLNHINHSNIIKINDYFITNDNLLIIdMDYFELGDLTKL-KQE---N 1205
                   68***********9988....5556669****8777776.9***********************9998888777769********875.443...6 PP

                   SBHHHHHHHHHHHHHHHHHHHH.TTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHH CS
  Pkinase_Tyr  100 ltlkdllsfalqvAkGmeyLes.kklvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWs 190 
                   ++ k + ++  q+ ++++y+++ ++++Hrd+   N+++++    n  + ++DfGLa++     +  + ++      +m+pE+   ++++ ++D++s
   EFC39765.1 1206 CSEKIVKQILKQMLNALKYVHEeMHIIHRDIKQTNIFIKKmtsdNIDIVLADFGLAKKY----QEMTGQSYAGTPLYMSPEVALGSSYSYNTDIFS 1297
                   88888889999*********75278**************97776778999*******99....3444555555667******************** PP

                   HHHHHHHHHTTSSGT.....TTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr  191 fGvllwEiftlgesp.....ypglkneevleklkegkrlekpekcpeelyelmkkcweedpeeRptfselv 256 
                    G+ ++ i+t+   +     + g ++e++++ lk++ + ++  + ++el e++ k +e+d+++Rp+ s+l+
   EFC39765.1 1298 LGISIYQIMTNDLATsisnlLMGNQAENAIKILKNQMKESAHCEYSDELIEIVLKMLEKDANQRPSASQLL 1368
                   *********9654333333344456666777777777777777779********************99986 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   0.0   0.00095       1.4       3      23 ..      75      95 ..      73     100 .. 0.89
   2 !    7.7   0.0    0.0026       3.8       1      27 [.     130     157 ..     130     158 .. 0.89
   3 !   20.9   0.0   1.7e-07   0.00026       1      28 []     172     199 ..     172     199 .. 0.97
   4 ?    1.3   0.0      0.28   4.2e+02       6      18 ..     277     289 ..     277     297 .. 0.84
   5 !    9.9   0.0   0.00053      0.79       1      27 [.     330     355 ..     330     356 .. 0.87
   6 ?   -1.2   0.0       1.7   2.5e+03       1      18 [.     798     816 ..     798     816 .. 0.89
   7 ?    3.5   0.0     0.055        82       8      26 ..     919     938 ..     913     940 .. 0.79

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00095
                SEEEEEEETTTEEEEEECCCT CS
         NHL  3 yPhGvavdsnGdiyVaDsenh 23
                +P+G+++  nGd++VaD  +h
  EFC39765.1 75 SPTGLSAGLNGDVFVADADRH 95
                699***************999 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0026
                 BSSEEEEEEE.TTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenhrvqv 27 
                 +n P+ ++v+  nGd+++aDs n+ +++
  EFC39765.1 130 LNTPTAISVNpLNGDLFIADSLNNKIRI 157
                 6889******99********98888765 PP

  == domain 3  score: 20.9 bits;  conditional E-value: 1.7e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 fn+P+Gv v+snG  y++D+ n+ ++++
  EFC39765.1 172 FNNPRGVYVSSNGFAYISDTDNNLIKKY 199
                 9************************987 PP

  == domain 4  score: 1.3 bits;  conditional E-value: 0.28
                 EEEEETTTEEEEE CS
         NHL   6 GvavdsnGdiyVa 18 
                 G+ v+++G+iy +
  EFC39765.1 277 GIYVSNGGEIYTS 289
                 899********86 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00053
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 f++P+++ + +++ i+VaD  n+++++
  EFC39765.1 330 FYEPSSLII-TQNAIIVADKSNSCIRK 355
                 778888888.69*************87 PP

  == domain 6  score: -1.2 bits;  conditional E-value: 1.7
                 BSSEEEEEEE.TTTEEEEE CS
         NHL   1 fnyPhGvavd.snGdiyVa 18 
                 fn  +G++v  ++Gd+++a
  EFC39765.1 798 FNLINGLTVEdTTGDLLIA 816
                 777899***99*****997 PP

  == domain 7  score: 3.5 bits;  conditional E-value: 0.055
                 EEETTTEEEEEE.CCCTEEE CS
         NHL   8 avdsnGdiyVaD.senhrvq 26 
                  v +nGdi++ D s+++ v+
  EFC39765.1 919 YVKKNGDIIILDgSGTSLVR 938
                 5559********99998875 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.1   0.1   5.8e-10   8.6e-07     311     398 ..    1214    1296 ..    1201    1298 .. 0.85

  Alignments for each domain:
  == domain 1  score: 28.1 bits;  conditional E-value: 5.8e-10
  Pkinase_fungal  311 alrDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhDLE 398 
                       l++ +++++  +++  i+HrDi   Ni i  + + ++   +L+D+ lak++++ + +s      GT+ +m+ ev  g++ sy  D+ 
      EFC39765.1 1214 ILKQMLNALKYVHEEMHIIHRDIKQTNIFIK-KMTSDNIDIVLADFGLAKKYQEMTGQS----YAGTPLYMSPEVALGSSYSYNTDIF 1296
                      56777888899999999**************.555578999************866666....58************99999999985 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   1.3   7.2e-06     0.011     106     166 ..    1197    1257 ..    1143    1267 .. 0.88

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 7.2e-06
  YrbL-PhoP_reg  106 nvaktLedlvkkeeltaelkeaLdefleelldnhivtndlsakNivvkknsegeeelvlvD 166 
                     ++ k  ++ ++++ +++ lk+ L++++    + hi+ +d++  Ni++kk   ++ ++vl D
     EFC39765.1 1197 DLTKLKQENCSEKIVKQILKQMLNALKYVHEEMHIIHRDIKQTNIFIKKMTSDNIDIVLAD 1257
                     5555556678889999999*************************************99999 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.1   2.3   8.8e-06     0.013      55     144 ..    1157    1248 ..    1128    1265 .. 0.85

  Alignments for each domain:
  == domain 1  score: 15.1 bits;  conditional E-value: 8.8e-06
                  HHHHHHHHHHHHHTT.--S--EEEEETTEEE..EE--EETTEEGGBHHHCG.-HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETTEE CS
        RIO1   55 aekEfrnLkrleeag.vpvPkpielkrhvlv..mefigedgvaapklkdve.eeeeaeelyeevleemrklykeaglvHaDLSeyNvlvdedkv 144 
                    kE ++L+ +++++ +++ +    +++ l+  m++ +     ++klk+ + +e+  +++++++l++++ + +e++++H D+ + N+++++   
  EFC39765.1 1157 IMKEASQLNHINHSNiIKINDYFITNDNLLIidMDYFE--LGDLTKLKQENcSEKIVKQILKQMLNALKYVHEEMHIIHRDIKQTNIFIKKMTS 1248
                  47999999999998878999999999999994455665..8889999999977999*******************************9987544 PP

>> ComR_TPR  ComR tetratricopeptide
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   5.4   1.5e-05     0.022      76     148 ..    1171    1245 ..    1148    1265 .. 0.87

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 1.5e-05
                  HHHHH-SS--HHH.HHHHHH.HHHHHCCS-TTSHHH..HHHHHHHHHHHHHTTTS-GGGHHHHHHHHHHHHHHHH CS
    ComR_TPR   76 eqvkkkkkyslND.lLiidl.Yltclsveklkeklfdkklfeklvekllnqeesleeedlfllrdvllsaltvll 148 
                  + +k + ++ +ND lLiid+ Y++  +  klk++  ++k+++++++++ln  ++++ee+ ++ rd+  + + ++ 
  EFC39765.1 1171 NIIKINDYFITNDnLLIIDMdYFELGDLTKLKQENCSEKIVKQILKQMLNALKYVHEEMHIIHRDIKQTNIFIKK 1245
                  557778899999979999998*******************************************99887777665 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   7.5   1.1e-05     0.017       5      32 .]    1030    1056 ..    1026    1056 .. 0.87

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 1.1e-05
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g+G+C +   +C+C+ g+ G  C
  EFC39765.1 1030 ENVCNGNGQCSDID-VCQCKIGFEGQFC 1056
                  789*******7555.9***********9 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.3     8e-05      0.12      68     256 ..    1134    1318 ..    1127    1361 .. 0.67

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 8e-05
  Kinase-like   68 llrgknpeqAkdhlrlllpfdlvkiqkkkpfiqlkskesiywvvnallllpaa.svdleilnkvlqkrsethkkletiarlllTlqlirlaanLqa 162 
                   + ++kn+ +A + +++    dl +i k     +  ++ +i  + ++++   +   +d++ +      + ++++  e+i +++l  q+++   + ++
   EFC39765.1 1134 D-LKKNKLKAIKLVKFETLTDLNTIMKEASQLNHINHSNIIKINDYFITNDNLlIIDMDYFELGDLTKLKQENCSEKIVKQIL-KQMLNALKYVHE 1227
                   5.467888888888888888999999888888888888888776666665553256887776433333334455567788999.789999999987 PP

  Kinase-like  163 k.glvhgkftvdnllldekg....glmlggftaLvragtkvvlsevekgfaPpEllgsrggytrknktkmthkldaWqlGlviyriwclklPltla 253 
                   +  ++h +++ +n++ ++       ++l +f+      +k++  ++ +++a   l  s           +++++d   lG++iy i   +l +   
   EFC39765.1 1228 EmHIIHRDIKQTNIFIKKMTsdniDIVLADFGL----AKKYQ-EMTGQSYAGTPLYMSPEV---ALGSSYSYNTDIFSLGISIYQIMTNDLATSIS 1315
                   538************998651111567777764....45555.677777777666666444...456799*****************999977655 PP

  Kinase-like  254 tee 256 
                     +
   EFC39765.1 1316 NLL 1318
                   444 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.8   8.4e-05      0.13     104     167 ..    1197    1259 ..    1183    1270 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.4e-05
         Kdo  104 dLedllakwaelaeelkrallkavgrliaklhr.agvnHadlyaknillqqeeeeeaeiwliDld 167 
                  dL++l ++  + +e+  +++lk+   + +  h+ +++ H+d+   ni++++  ++++ i+l D+ 
  EFC39765.1 1197 DLTKLKQE--NCSEKIVKQILKQMLNALKYVHEeMHIIHRDIKQTNIFIKKMTSDNIDIVLADFG 1259
                  67766664..7999999***************6369***************************96 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.0   3.9   0.00055      0.82       4      31 ..    1031    1054 ..    1028    1055 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00055
                  TTSTTT-EEEEETTTEEEEEECTTEEST CS
         EGF    4 npCsngGtCvdtgrggytCiCpeGytGk 31  
                  n C+++G C d       C+C++G+ G 
  EFC39765.1 1031 NVCNGNGQCSDID----VCQCKIGFEGQ 1054
                  55*******9999....********995 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   5.8    0.0067        10       1      22 []    1033    1051 ..    1033    1051 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0067
                  --TT-EES..-SS.-EE--TTX CS
        hEGF    1 CnngGtCidgvggykCiCpPGy 22  
                  Cn++G+C d     +C+C+ G+
  EFC39765.1 1033 CNGNGQCSDI---DVCQCKIGF 1051
                  ********44...59****998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       683  (0.0380947); expected 358.6 (0.02)
Passed bias filter:                      339  (0.0189079); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.87u 0.36s 00:00:01.23 Elapsed: 00:00:00.55
# Mc/sec: 7521.39
//
Query:       EFC39766.1  [L=432]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.022   15.2   2.8        7.8    7.1   0.0    4.5  5  LRR_4     Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1     0.023   4.2e+02      22      38 ..     236     252 ..     229     257 .. 0.68
   2 ?   -0.1   0.2      0.08   1.4e+03       3      18 ..     239     255 ..     237     291 .. 0.55
   3 ?   -0.1   0.1     0.081   1.5e+03      21      30 ..     291     300 ..     267     304 .. 0.80
   4 ?    7.1   0.0   0.00043       7.8      19      36 ..     322     339 ..     311     349 .. 0.74
   5 ?    2.0   0.0     0.018   3.2e+02      21      33 ..     381     393 ..     369     409 .. 0.76

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.023
                 -TT--EEE-..-S----- CS
       LRR_4  22 lpnLkeLdL.sgNnlitd 38 
                 l++Lk L + sg+  ++d
  EFC39766.1 236 LTSLKNLRIvSGC-ILDD 252
                 6777777776777.5555 PP

  == domain 2  score: -0.1 bits;  conditional E-value: 0.08
                 --EEE--.SS---E-S- CS
       LRR_4   3 LevLdLs.nNqltdipl 18 
                 L++L +  ++ l d+++
  EFC39766.1 239 LKNLRIVsGCILDDVQS 255
                 44444443344444444 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.081
                 H-TT--EEE- CS
       LRR_4  21 klpnLkeLdL 30 
                  +pnL+++++
  EFC39766.1 291 MCPNLEKISI 300
                 4899999887 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.00043
                 HHH-TT--EEE-.-.S--- CS
       LRR_4  19 leklpnLkeLdLsg.Nnli 36 
                 l+ lp+Lk+L+L g + +i
  EFC39766.1 322 LKALPKLKHLNL-GvCHQI 339
                 445********9.425455 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.018
                 H.-TT--EEE-.-S CS
       LRR_4  21 k.lpnLkeLdLsgN 33 
                 + lpnL +L + gN
  EFC39766.1 381 GmLPNLYYLEI-GN 393
                 45*********.66 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (432 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       360  (0.0200792); expected 358.6 (0.02)
Passed bias filter:                      240  (0.0133861); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 2446.14
//
Query:       EFC39767.1  [L=369]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00011   21.5   0.1    0.00031   20.1   0.1    1.8  1  CHZ              Histone chaperone domain CHZ


Domain annotation for each model (and alignments):
>> CHZ  Histone chaperone domain CHZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.1   0.1   1.7e-08   0.00031       8      34 .]      85     109 ..      84     109 .. 0.85

  Alignments for each domain:
  == domain 1  score: 20.1 bits;  conditional E-value: 1.7e-08
         CHZ   8 EIDtsNIIsgGRRTRgktiDfakaaek 34 
                 E D sNI+  G R R+k++++++ +ek
  EFC39767.1  85 EFDSSNIVA-GTR-RRKNVNYKSLEEK 109
                 569*****9.666.6*******99886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (369 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2775  (0.154777); expected 358.6 (0.02)
Passed bias filter:                      602  (0.0335769); expected 358.6 (0.02)
Passed Vit filter:                        93  (0.00518713); expected 17.9 (0.001)
Passed Fwd filter:                        27  (0.00150594); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 2103.74
//
Query:       EFC39768.1  [L=1118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    6.8e-54  183.0   1.0    1.1e-53  182.3   1.0    1.3  1  Pkinase         Protein kinase domain
    8.2e-31  107.2   0.3    1.2e-30  106.6   0.3    1.2  1  Pkinase_Tyr     Protein tyrosine kinase
    5.9e-07   28.6   0.1    1.1e-06   27.7   0.1    1.4  1  Pkinase_fungal  Fungal protein kinase
      0.003   17.5   2.2      0.006   16.5   2.2    1.4  1  TMEM154         TMEM154 protein family
  ------ inclusion threshold ------
      0.011   15.6   3.6      0.029   14.3   3.6    1.6  1  DUF3377         Domain of unknown function (DUF3377)
      0.033   14.5  21.6       0.82   10.1   8.7    2.7  2  EGF_2           EGF-like domain
      0.061   12.7   0.1        0.1   11.9   0.1    1.2  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
      0.063   13.3   7.6         11    6.3   0.0    5.6  7  NHL             NHL repeat
      0.087   12.9   3.8        7.2    6.7   0.0    4.8  5  DUF5074         Domain of unknown function (DUF5074)
      0.087   12.7   0.8       0.19   11.6   0.8    1.5  1  Tmemb_9         TMEM9
      0.091   12.3   0.1       0.26   10.8   0.1    1.7  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL
       0.16   11.8   6.1       0.11   12.3   3.2    2.1  2  ECSCR           Endothelial cell-specific chemotaxis regulato
       0.58    9.9   3.1        1.1    9.0   3.1    1.4  1  ASFV_J13L       African swine fever virus J13L protein
        1.8    8.5   4.3        4.5    7.3   4.3    1.6  1  DUF4389         Domain of unknown function (DUF4389)


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  182.3   1.0   8.4e-57   1.1e-53       3     264 .]     861    1117 ..     859    1117 .. 0.89

  Alignments for each domain:
  == domain 1  score: 182.3 bits;  conditional E-value: 8.4e-57
                  EEEEEEEESSEEEEEEEETTT.TEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEE.EEEE--TTEBHHHHHHHHSS--H CS
     Pkinase    3 kleklGeGsfGkVykaveket.gkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdely.lvleyveggeladllerkgslse 97  
                  ++ ++G+G+fG+V+k+++++  +ki AvK +k e+ ++ +  ++++E + + +++hpni+ + ++f +kd+l+ + ++y e+g+l+++ + k + se
  EFC39768.1  861 NMVRIGQGAFGSVFKVTDTKCgNKIKAVKFVKFESFTDLN--TIMKEASQFSNIRHPNILIINDYFITKDNLLcMDMDYFENGDLTRFTK-KETCSE 954 
                  5679*************98761567799999999999876..5************************999976599************97.799*** PP

                  HHHHHHHHHHHHHHHHHHHT.TEE-SS-SGGGEEEE.TTTE...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHHTTSCBSHHHHHHHHHHHHHH CS
     Pkinase   98 eeakkiakqilegleylHsk.giiHrDlKpeNiLid.ekge...lKitDFGlakelessskltsfvgtseYlAPEvlkeneyskkvDvWslGvilye 189 
                  + ++ki+kq+l++l+y+Hs+ +iiHrD+Kp+Ni+i   +g+   + ++DFGlak+ ++ +  +s+ gt+ +++PE+  ++ ys ++D++slGv +y+
  EFC39768.1  955 DIIRKIMKQVLSALDYVHSElSIIHRDIKPSNIFIRnLSGNdieVVLADFGLAKKHQEMK-GHSYAGTPLFMSPEIALGSCYSFNTDIFSLGVSIYQ 1050
                  ******************6526*************954555677***********99988.9*********************************** PP

                  HHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase  190 lltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeellqhpyl 264 
                  ++t+ +  s   g+     + +q  + + il   +++++ +++ s+e+ +++ k+l++++++R++a+++lq py+
  EFC39768.1 1051 IMTKDETIS--IGNL---LMGNQSANAVSIL---TKQMEAEQQYSNELMEIVIKMLDRNQETRPSARQILQMPYF 1117
                  *********..3332...3444444455665...569999**********************************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  106.6   0.3   9.6e-34   1.2e-30       6     257 ..     864    1113 ..     860    1114 .. 0.86

  Alignments for each domain:
  == domain 1  score: 106.6 bits;  conditional E-value: 9.6e-34
                   EEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEE.SSSSEEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr    6 klGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvct.keepllivteyvkgGdLlkfLrkkekekl 100 
                   ++G+GafG+V++ t +  k   +   avK +k e+  +  + +++ea+ +++++hpni+ +    + k++ l++ ++y ++GdL  f +k+   ++
   EFC39768.1  864 RIGQGAFGSVFKVTDT--KCG-NKIKAVKFVKFESFTD-LNTIMKEASQFSNIRHPNILIINDYFItKDNLLCMDMDYFENGDLTRFTKKE---TC 952 
                   79**********9988..444.44459****8777776.99******************99998874677799**************9887...78 PP

                   BHHHHHHHHHHHHHHHHHHHHT.TEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSEEEHHHHHHHH CS
  Pkinase_Tyr  101 tlkdllsfalqvAkGmeyLesk.klvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekkftsksDvWsf 191 
                   + + + +++ qv ++++y++s+ +++Hrd+   N+++++    +  v ++DfGLa+++    +  k ++      +m+pE+   + ++ ++D++s 
   EFC39768.1  953 SEDIIRKIMKQVLSALDYVHSElSIIHRDIKPSNIFIRNlsgnDIEVVLADFGLAKKH----QEMKGHSYAGTPLFMSPEIALGSCYSFNTDIFSL 1044
                   8888889************987469************98887677999********99....44455555566679******************** PP

                   HHHHHHHHTTSSGT.TTTS.HHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr  192 GvllwEiftlgesp.ypgl.kneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRptfselve 257 
                   Gv ++ i+t+ e+  + +l + ++ ++++    k++e+ ++ ++el+e++ k +++++e Rp+ +++++
   EFC39768.1 1045 GVSIYQIMTKDETIsIGNLlMGNQSANAVsILTKQMEAEQQYSNELMEIVIKMLDRNQETRPSARQILQ 1113
                   *********88865244445666666666588999*****************************99975 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.7   0.1     9e-10   1.1e-06     313     397 ..     962    1041 ..     951    1044 .. 0.84

  Alignments for each domain:
  == domain 1  score: 27.7 bits;  conditional E-value: 9e-10
  Pkinase_fungal  313 rDaIkghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgeeHsyrhDL 397 
                      ++++ ++   +++  i+HrDi   Ni i +  + ++ + +L+D+ lak++++ + +s      GT+ Fm+ e+  g+  s+  D+
      EFC39768.1  962 KQVLSALDYVHSELSIIHRDIKPSNIFIRNL-SGNDIEVVLADFGLAKKHQEMKGHS----YAGTPLFMSPEIALGSCYSFNTDI 1041
                      556677777888889**************54.55699**************876666....58**********999999999887 PP

>> TMEM154  TMEM154 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   2.2   4.6e-06     0.006      45      92 ..     771     822 ..     756     842 .. 0.63

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 4.6e-06
     TMEM154  45 ssaelsnesdqlelvlmiiiPlv..llillllvv..iiliqkkkrkrsKdde 92 
                 s  +l+n+++   lv+ i+iP v   li++++vv  iil  +kk+k  K +e
  EFC39768.1 771 SLDNLANDQSTTVLVVAIVIPIVgiGLIIVIIVVvvIILLSMKKKKAVKRNE 822
                 4456778888888899999**9843233333333003333344444444443 PP

>> DUF3377  Domain of unknown function (DUF3377)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   3.6   2.2e-05     0.029      20      59 ..     777     819 ..     770     821 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 2.2e-05
     DUF3377  20 ddeesgtvnaiaVvvPlv...LllciLvliyailq.frrkgtpr 59 
                 +d+ s+tv ++a+v+P+v   L+++i+v++++il  +++k + +
  EFC39768.1 777 NDQ-STTVLVVAIVIPIVgigLIIVIIVVVVIILLsMKKKKAVK 819
                 455.999*********9877777777777776666699998765 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   4.9   0.00093       1.2      17      32 .]     713     728 ..     703     728 .. 0.76
   2 ?   10.1   8.7   0.00064      0.82       5      32 .]     741     767 ..     737     767 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00093
       EGF_2  17 qcGqCdCdsgyqGktC 32 
                 +++ CdC sg++G++C
  EFC39768.1 713 FNNTCDCLSGFYGDKC 728
                 4458************ PP

  == domain 2  score: 10.1 bits;  conditional E-value: 0.00064
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g G+Cv +   C C +g+ G  C
  EFC39768.1 741 SKSCNGKGSCVGLD-ICNCITGFDGQFC 767
                 567********666.8***********9 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.1   8.1e-05       0.1     104     170 ..     942    1008 ..     927    1016 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 8.1e-05
         Kdo  104 dLedllakwaelaeelkrallkavgrliaklhr.agvnHadlyaknillqqeeeeeaeiwliDldkar 170 
                  dL+ + +k ++ +e   r+++k+v  +    h+ + + H+d+ + ni++++  ++++e++l D+  a+
  EFC39768.1  942 DLTRFTKK-ETCSEDIIRKIMKQVLSALDYVHSeLSIIHRDIKPSNIFIRNLSGNDIEVVLADFGLAK 1008
                  78888886.779999*****************73689***************99*********97655 PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0      0.47     6e+02      15      27 ..      48      60 ..      41      61 .. 0.92
   2 ?   -2.9   0.0       7.2   9.2e+03       2      16 ..     152     159 ..     151     161 .. 0.54
   3 ?   -2.6   0.0       5.6   7.2e+03      13      21 ..     277     285 ..     277     286 .. 0.80
   4 ?   -1.3   0.0       2.2   2.8e+03       8      21 ..     380     394 ..     377     395 .. 0.82
   5 ?    0.1   0.1      0.75   9.7e+02      15      22 ..     448     455 ..     445     455 .. 0.82
   6 ?    4.4   0.0     0.034        44       6      18 ..     495     508 ..     494     508 .. 0.94
   7 ?    6.3   0.0    0.0086        11      11      27 ..     617     633 ..     613     634 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.47
                EEEEECCCTEEEE CS
         NHL 15 iyVaDsenhrvqv 27
                +y  D  n+++++
  EFC39768.1 48 VYLVDKSNNCIRK 60
                799********87 PP

  == domain 2  score: -2.9 bits;  conditional E-value: 7.2
                 SSEEEEEEETTTEEE CS
         NHL   2 nyPhGvavdsnGdiy 16 
                 ++       +nGd++
  EFC39768.1 152 CF-------PNGDLV 159
                 44.......566666 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 5.6
                 TEEEEEECC CS
         NHL  13 GdiyVaDse 21 
                 G iyVa+ +
  EFC39768.1 277 GKIYVANGY 285
                 89****854 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 2.2
                 EEE.TTTEEEEEECC CS
         NHL   8 avd.snGdiyVaDse 21 
                 + d +++ iy+ D +
  EFC39768.1 380 CRDpNQNLIYIIDKN 394
                 778899*****9976 PP

  == domain 5  score: 0.1 bits;  conditional E-value: 0.75
                 EEEEECCC CS
         NHL  15 iyVaDsen 22 
                 iyVaD+++
  EFC39768.1 448 IYVADYCR 455
                 9****985 PP

  == domain 6  score: 4.4 bits;  conditional E-value: 0.034
                 EEEEE.TTTEEEEE CS
         NHL   6 Gvavd.snGdiyVa 18 
                 G++v+ +nGdiy++
  EFC39768.1 495 GLSVNpKNGDIYIC 508
                 99**********97 PP

  == domain 7  score: 6.3 bits;  conditional E-value: 0.0086
                 TTTEEEEEECCCTEEEE CS
         NHL  11 snGdiyVaDsenhrvqv 27 
                  nGdi++ Ds+n+ +++
  EFC39768.1 617 ENGDIIILDSGNNIIRK 633
                 69**********97766 PP

>> DUF5074  Domain of unknown function (DUF5074)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.2      0.39     5e+02      28      86 ..     172     226 ..     165     243 .. 0.74
   2 ?    0.1   0.1      0.62     8e+02       7      33 ..     277     303 ..     272     370 .. 0.58
   3 ?    0.3   0.0      0.54     7e+02      44      78 ..     374     402 ..     358     410 .. 0.74
   4 ?    6.7   0.0    0.0056       7.2       5      34 ..     444     473 ..     440     481 .. 0.88
   5 ?   -2.6   0.0       4.2   5.4e+03     101     113 ..     495     507 ..     493     508 .. 0.88

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.39
     DUF5074  28 ktvelpelsiesswyawtptslcasttenaLYfiggsswfsgkkiykydidtetlseel 86 
                 +t+ ++ ++i++s    + t +  s+ + ++Y+      +s+  iyky+ +t + s+++
  EFC39768.1 172 DTLRMRYFQINYSNPISSITGFGNSFDNGTMYIGF----VSSDGIYKYQNETLQDSSKI 226
                 56666667778888778888888888888888854....55999****88887766554 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.62
     DUF5074   7 GnvWaasgtkLvkinpktlevktvelp 33 
                 G++++a+g ++++ n  +l+  +v   
  EFC39768.1 277 GKIYVANGYRIYEANLDDLSLRKVGGI 303
                 889999777777777777776655433 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.54
     DUF5074  44 wtptslcasttenaLYfiggsswfsgkkiykydid 78 
                    +s+c   ++n +Y+i+++       + kyd +
  EFC39768.1 374 MDMNSFCRDPNQNLIYIIDKN------VLKKYDEK 402
                 56679999999*******999......44555544 PP

  == domain 4  score: 6.7 bits;  conditional E-value: 0.0056
     DUF5074   5 kDGnvWaasgtkLvkinpktlevktvelpe 34 
                 +D  +++a   ++++i+pktl++++v+ +e
  EFC39768.1 444 YDNMIYVADYCRIIQIDPKTLKYQKVAGKE 473
                 6999******************99998666 PP

  == domain 5  score: -2.6 bits;  conditional E-value: 4.2
     DUF5074 101 girvdpvtdelyl 113
                 g+ v+p+++++y+
  EFC39768.1 495 GLSVNPKNGDIYI 507
                 899********97 PP

>> Tmemb_9  TMEM9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.8   0.00015      0.19      10     115 ..     741     848 ..     734     862 .. 0.55

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00015
     Tmemb_9  10 skkcnceg.vvlpklsdevkgkelefcprCeCkyesRntttikvvviivivvislLviYmlflllldplln.krkkkasyqehtneedetseslssasq 106
                 sk+cn +g  v   + + ++g + +fc r +      +  t  +vv ivi ++++ +i +++++++  ll+ k+kk+++ +e  n    ++++++s+s 
  EFC39768.1 741 SKSCNGKGsCVGLDICNCITGFDGQFCERSSLDNLANDQSTTVLVVAIVIPIVGIGLIIVIIVVVVIILLSmKKKKAVKRNEIANATIVEMSDFPSSSV 839
                 566766542233345568999999999998877655555555556666666666544444444444444442334566666666666444455554444 PP

     Tmemb_9 107 slelrarsn 115
                   +++  sn
  EFC39768.1 840 IISSSMGSN 848
                 333333333 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.1    0.0002      0.26     112     166 ..     949    1003 ..     935    1011 .. 0.84

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.0002
  YrbL-PhoP_reg  112 edlvkkeeltaelkeaLdefleelldnhivtndlsakNivvkknsegeeelvlvD 166 
                     ++ ++++ + + +k+ L ++     ++ i+ +d++++Ni++++ s ++ e+vl D
     EFC39768.1  949 KETCSEDIIRKIMKQVLSALDYVHSELSIIHRDIKPSNIFIRNLSGNDIEVVLAD 1003
                     46778888888899999999999999**********************9999998 PP

>> ECSCR  Endothelial cell-specific chemotaxis regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       1.6     2e+03      70      83 ..       7      20 ..       2      33 .. 0.76
   2 ?   12.3   3.2   8.8e-05      0.11      12      47 ..     776     815 ..     768     863 .. 0.67

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.6
       ECSCR 70 escstaigekdsit 83
                 s+ t igekds  
  EFC39768.1  7 SSTKTIIGEKDSFG 20
                567899*****975 PP

  == domain 2  score: 12.3 bits;  conditional E-value: 8.8e-05
       ECSCR  12 psptsetvltvaa....fgvisfivilvvvviilvsvvsl 47 
                     s tvl va      g+  +ivi+vvvviil+s+   
  EFC39768.1 776 ANDQSTTVLVVAIvipiVGIGLIIVIIVVVVIILLSMKKK 815
                 5667899999986222246666788888888998887543 PP

>> ASFV_J13L  African swine fever virus J13L protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0   3.1   0.00087       1.1      34      61 ..     788     819 ..     772     834 .. 0.66

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00087
   ASFV_J13L  34 iliaiv....vliiiiivliylfssrkkkaaa 61 
                 i+i iv    +++ii++v+i l+s +kkka  
  EFC39768.1 788 IVIPIVgiglIIVIIVVVVIILLSMKKKKAVK 819
                 44444422213445556678899999999865 PP

>> DUF4389  Domain of unknown function (DUF4389)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   4.3    0.0035       4.5      11      46 ..     783     818 ..     781     821 .. 0.89

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0035
     DUF4389  11 mllfaivlslaslvlwvvvvvqflivLvtgrpnepL 46 
                 +l++aiv+ +++++l++v++v+++i+L++ ++ +++
  EFC39768.1 783 VLVVAIVIPIVGIGLIIVIIVVVVIILLSMKKKKAV 818
                 799*************************97777665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1049  (0.0585086); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        74  (0.00412739); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.85u 0.30s 00:00:01.14 Elapsed: 00:00:00.50
# Mc/sec: 6724.10
//
Query:       EFC39769.1  [L=259]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.4e-14   51.2   1.2    5.6e-05   23.0   0.0    3.5  3  NHL       NHL repeat


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.9   0.0   4.5e-05       0.8       6      26 ..      64      84 ..      60      86 .. 0.86
   2 !   15.5   0.0   7.3e-07     0.013       1      22 [.     114     135 ..     114     139 .. 0.94
   3 !   23.0   0.0   3.1e-09   5.6e-05       1      28 []     155     182 ..     155     182 .. 0.93

  Alignments for each domain:
  == domain 1  score: 9.9 bits;  conditional E-value: 4.5e-05
                EEEEETTTEEEEEECCCTEEE CS
         NHL  6 GvavdsnGdiyVaDsenhrvq 26
                G++  +n++i+V+D+ +  ++
  EFC39769.1 64 GICSGNNDEIFVSDCVRGLIF 84
                9*************9887776 PP

  == domain 2  score: 15.5 bits;  conditional E-value: 7.3e-07
                 BSSEEEEEEETTTEEEEEECCC CS
         NHL   1 fnyPhGvavdsnGdiyVaDsen 22 
                 fn+P++++v  nGd+++aD++n
  EFC39769.1 114 FNSPSSLSVAINGDLWIADTNN 135
                 99******************99 PP

  == domain 3  score: 23.0 bits;  conditional E-value: 3.1e-09
                 BSSEEEEEEETTTEEEEEECCCTEEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqvF 28 
                 fn P Gv v++n+ +y+aDs+n+ ++++
  EFC39769.1 155 FNKPLGVYVSNNNILYIADSGNNVIKKY 182
                 99********************977765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (259 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       605  (0.0337442); expected 358.6 (0.02)
Passed bias filter:                      484  (0.0269954); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.51u 0.27s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1740.89
//
Query:       EFC39770.1  [L=1243]
Description: hypothetical protein NAEGRDRAFT_72393 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.5e-20   73.5   0.1    3.9e-20   72.2   0.1    1.7  1  G8          G8 domain
     0.0047   16.2  10.5     0.0081   15.5   0.5    4.0  4  NosD        Periplasmic copper-binding protein (NosD)
     0.0052   16.7   7.9     0.0052   16.7   7.9    4.5  4  Beta_helix  Right handed beta helix region
  ------ inclusion threshold ------
      0.027   15.5   0.0      0.076   14.0   0.0    1.8  1  CHRD        CHRD domain


Domain annotation for each model (and alignments):
>> G8  G8 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.2   0.1   8.6e-24   3.9e-20      10     123 .]      45     166 ..      38     166 .. 0.89

  Alignments for each domain:
  == domain 1  score: 72.2 bits;  conditional E-value: 8.6e-24
          G8  10 egdnvvIpagktvlld.vsspklrsllve..GtLifsddksdielnaeyilvqggGkleiGteeepfkgkatItLyG......teewsstelpdlgaKv 99 
                 +++ +vI++g++vl+  + + k+ s++v+  G+Lif d+ + +++n+++i v+g++++++G+ ++p+ +k+tIt+yG      t  +++ ++ +lg+K+
  EFC39770.1  45 AESAIVITSGQKVLIKtSPPVKYGSITVQsgGSLIF-DN-KFMNINVNHIRVEGNASFIMGSTSCPIYKKITITFYGprstenTLGTDPYDNANLGNKG 141
                 67899**********9355556**************.88.9*************************************99887777788889******* PP

          G8 100 lavsngGtlelhGqprkk.twtkLa 123
                 +a  +g t++++Gq  +   wt+L+
  EFC39770.1 142 IAFLTGATVQVVGQLINDkAWTRLN 166
                 *************7765439***96 PP

>> NosD  Periplasmic copper-binding protein (NosD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.4   0.1    0.0089        40     150     181 ..      66      96 ..      36     116 .. 0.78
   2 ?   -1.5   0.2      0.28   1.2e+03      40     101 ..     141     212 ..     123     237 .. 0.51
   3 !   15.5   0.5   1.8e-06    0.0081      59     132 ..     306     387 ..     282     432 .. 0.73
   4 ?    1.2   0.0     0.041   1.8e+02      43      87 ..     613     656 ..     575     661 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.0089
        NosD 150 kiGilllsssegntiynNyFinnsenvkydgs 181
                 k+G   + +s g +i++N F+n ++n   +++
  EFC39770.1  66 KYGSI-TVQSGGSLIFDNKFMNINVNHIRVEG 96 
                 67888.9999**********997766554443 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.28
        NosD  40 gilldnssnntitgntienl....ryGihlensesntiedntlssne..sGialmsssnn.tle...nNtis 101
                 gi++ +  ++++ g  i++      ++  l+n++s+t++++++ + +  + i+l+s+    +++    N  s
  EFC39770.1 141 GIAFLTGATVQVVGQLINDKawtrLNATALKNTSSITLKESVTGMWSvgDDILLTSTDYGeVVDfkiMNDTS 212
                 555555555555555555544444455555555555555555544443333444444433233222222223 PP

  == domain 3  score: 15.5 bits;  conditional E-value: 1.8e-06
        NosD  59 l...ryGihlenses........ntiedntlssne.sGialmsssnntlenNtisnnenyGillsdssn..ntisnNtisnnnkGifl 132
                 +   ryG+hl   ++          i +n + +++ + i++++s+n  ++nN+  n +++ ++l+d s+  n+ +nN       G+++
  EFC39770.1 306 GlmgRYGLHLHLLKDtskqistqFMIANNAIWNSYqRCIVIHDSRNILVKNNICFNITGHAFYLEDGSEfgNEFRNN------LGVKV 387
                 24558999988877777889988899999999999899999999988999999999999*****9999844444444......44443 PP

  == domain 4  score: 1.2 bits;  conditional E-value: 0.041
        NosD  43 ldnssnntitgntienlryGihlensesntiedntlssne.sGial 87 
                 +++ s ++++     n   G+++ ns++ ++ +nt ++n+ +Gi+ 
  EFC39770.1 613 VSHRSRKQLES--AVNKLFGLTFINSNKFYALNNTPYDNQrMGIWA 656
                 45555555555..345568999999999999999999999899976 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   1.0     0.061   2.7e+02      23      62 ..      67     104 ..      37     231 .. 0.64
   2 !   16.7   7.9   1.2e-06    0.0052      57     137 ..     329     420 ..     321     435 .. 0.47
   3 !    5.2   0.2    0.0037        17      13     120 ..     498     656 ..     492     665 .. 0.56
   4 ?   -4.3   1.0       3.2   1.4e+04     125     147 ..    1067    1089 ..    1049    1101 .. 0.54

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.061
                 S-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES- CS
  Beta_helix  23 gyGiylrgssnvvienneiannsgsGiyilgssnntisnn 62 
                 +  i+++++++ +i +n++ n + + i+++g   + i ++
  EFC39770.1  67 YGSITVQSGGS-LIFDNKFMNINVNHIRVEGN-ASFIMGS 104
                 55666677776.44447777766666666663.3333222 PP

  == domain 2  score: 16.7 bits;  conditional E-value: 1.2e-06
                 -EEES-EEE---SEEE-TT--S--EEES-EEES-SS-SEE-TT-S-..-EEES-EEESTT....--SEE---TT.....---EEES-EEES- CS
  Beta_helix  57 ntisnntisdnngggialfgasnnlienneitdnggsGiylnyssn..ntienNiidnna....gsGividdss.....snvtvtnNtitnn 137
                 + i nn i ++++  i + ++ n l++nn +++  g+ +yl++ s   n ++nN    ++    ++ ++i +s+     +++t  nNt+ +n
  EFC39770.1 329 FMIANNAIWNSYQRCIVIHDSRNILVKNNICFNITGHAFYLEDGSEfgNEFRNNLGVKVNpvgdADQLQIIPSDcdasvYWITNPNNTFIGN 420
                 34444444444444455555555555555555554445555443333344444444444444444444444444444444444444444444 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.0037
                 EESEEEES-SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EE.......E---............SEEE-TT--S--EEES-EEES-SS CS
  Beta_helix  13 iknntisnsggyGiylrgssnvvienneiannsgsGiyilgssnntisnnti.......sdnn............gggialfgasnnlienneitdngg 92 
                 +  +t +++ +yG +++g+    +e n +a   ++++ i+  ++ ti++n+i          +             +   l++++  +i++ e+++ +g
  EFC39770.1 498 FFRFTAYKNRDYGAWVKGGVL-YLE-NFLA--FDNNVQITAPKGPTITRNSImigetsnV--GdssfrskvdvggRTRPQLYASDELIIRGYEVYEDDG 590
                 556666777777777776665.666.3333..4667777777888999999877765440..2555556666666455555555555555555555543 PP

                 -......................................SEE-TT-S--EEES-EEESTT--SEE- CS
  Beta_helix  93 s......................................GiylnyssnntienNiidnnagsGivi 120
                                                        G+++ +s+     nN+ ++n+++Gi  
  EFC39770.1 591 PqllynctfinfipdaykasgavshrsrkqlesavnklfGLTFINSNKFYALNNTPYDNQRMGIWA 656
                 333333333333333333334444444555555555666777777777777777777777777754 PP

  == domain 4  score: -4.3 bits;  conditional E-value: 3.2
                  ---EEES-EEES-SSEEEE-TT- CS
  Beta_helix  125 snvtvtnNtitnnkgaGiavvgs 147 
                  +++  + +t+t+n++a+ +v+g 
  EFC39770.1 1067 TDNLNSFSTVTGNGDASYEVNGE 1089
                  33333555666666555555554 PP

>> CHRD  CHRD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.0   1.7e-05     0.076      82     116 .]     998    1032 ..     925    1032 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1.7e-05
        CHRD   82 aatlteeqlaalkagelyvnvhteefpgGeiRGql 116 
                    +l+ +++ al++g+++v ++t+++p+G +R ql
  EFC39770.1  998 LLDLSYQEQVALLKGQMFVKLSTTQNPTGHLRAQL 1032
                  44555566667999*******************97 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1243 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       406  (0.0226449); expected 358.6 (0.02)
Passed bias filter:                      353  (0.0196888); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.87u 0.34s 00:00:01.21 Elapsed: 00:00:00.53
# Mc/sec: 7081.82
//
Query:       EFC39771.1  [L=171]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (171 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       776  (0.0432818); expected 358.6 (0.02)
Passed bias filter:                      224  (0.0124937); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.27s 00:00:00.77 Elapsed: 00:00:00.46
# Mc/sec: 1114.61
//
Query:       EFC39772.1  [L=318]
Description: silent information regulator family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.1e-52  176.1   0.0    8.3e-52  175.7   0.0    1.2  1  SIR2             Sir2 family
     0.0027   17.3   1.1     0.0027   17.3   1.1    1.8  2  Desulfoferrod_N  Desulfoferrodoxin, N-terminal domain
  ------ inclusion threshold ------
       0.14   12.3   3.0       0.34   11.0   3.0    1.7  1  PHD_4            PHD-finger
       0.48   10.5   3.1       0.42   10.7   0.3    2.2  2  XPA_N            XPA protein N-terminal


Domain annotation for each model (and alignments):
>> SIR2  Sir2 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  175.7   0.0   1.8e-55   8.3e-52       1     177 []      41     233 ..      41     233 .. 0.92

  Alignments for each domain:
  == domain 1  score: 175.7 bits;  conditional E-value: 1.8e-55
                 -GGGGGGGT---SSS.TTSHHHH..SCHHHHSSHHHHHHHHHHHHH..HHHHHHHHHHCCTSS--HHHHHHHHHHHTTCEEEEEES-SSSHHHHTT-S. CS
        SIR2   1 GAGiStesGipdfRs.keGlyak..lakeelaspealfskkllvee..vfyniarellaeeaepnaaHkalkklekkgkllrliTQNiDgLekkaGsk. 93 
                 GAG+St++GipdfR   +Gl+ +  l+k+e+++p+ +f++ +++e+  +f + +++ +a+e++p+++H ++k l++k+kl+rl+TQNiDgLe+k+G++ 
  EFC39772.1  41 GAGLSTSCGIPDFRTpGKGLFVNgsLDKYEVKDPTSIFEIGYFKENpiPFFERMKNFIATEYKPSKTHFFIKLLQDKNKLMRLYTQNIDGLERKSGVSd 139
                 9**************9*****863378889*****************99************************************************99 PP

                 .SEEETTEEEEEEEETTTSBEEECCGGHCHHHCCTT......B-TTTCCBEEEEE--CTSB-SHHHHHHH....HHHHH-SEEEEES--STSTT CS
        SIR2  94 .kvvelHGslakakcvkcekkldkeelqeeieaekvp.....ecekcgkllkpdvvfFGealpdklkkli....ekveeadlllviGtSlkVap 177
                   +v++HG+l++ +c++c+k+++ ++l++++++e+++     +c+ cg+++k+dvv++Ge+lpdk+ +++    +k +++ l++viGtSl+V+p
  EFC39772.1 140 eLLVHCHGKLHTSHCMHCKKQFTLQYLRDQMTSESEEevqipKCNVCGNIVKTDVVLYGEDLPDKFGECVfqdlKKHKNCKLFIVIGTSLQVYP 233
                 899***********************9999987765556666***********************99986332257789*************98 PP

>> Desulfoferrod_N  Desulfoferrodoxin, N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.9   1.7         4   1.8e+04       9      12 ..     154     157 ..     153     157 .. 0.88
   2 !   17.3   1.1     6e-07    0.0027       2      17 ..     176     191 ..     175     197 .. 0.89

  Alignments for each domain:
  == domain 1  score: -4.9 bits;  conditional E-value: 4
                      -TTT CS
  Desulfoferrod_N   9 CevC 12 
                      C++C
       EFC39772.1 154 CMHC 157
                      ***9 PP

  == domain 2  score: 17.3 bits;  conditional E-value: 6e-07
                      -TT-EEE-TTT--EEE CS
  Desulfoferrod_N   2 eklevYkCevCGniVe 17 
                      e+ ++ kC+vCGniV+
       EFC39772.1 176 EEVQIPKCNVCGNIVK 191
                      678999*********7 PP

>> PHD_4  PHD-finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   3.0   7.6e-05      0.34       3      43 ..     150     193 ..     149     220 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 7.6e-05
       PHD_4   3 vtaaCivCgedgkedevv...eeesetpsslmeCsvCyeivHpe 43 
                 +t+ C++C+++ + +      ++ese++ ++  C+vC +iv  +
  EFC39772.1 150 HTSHCMHCKKQFTLQYLRdqmTSESEEEVQIPKCNVCGNIVKTD 193
                 799*******9988865555555688888999********9776 PP

>> XPA_N  XPA protein N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.3   9.4e-05      0.42       3      18 ..     153     168 ..     151     169 .. 0.91
   2 ?   -1.0   0.2      0.41   1.9e+03       2       8 ..     181     187 ..     181     191 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 9.4e-05
       XPA_N   3 kCdeCgkefldSyLld 18 
                 +C++C+k+f  +yL d
  EFC39772.1 153 HCMHCKKQFTLQYLRD 168
                 8*************87 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.41
       XPA_N   2 pkCdeCg 8  
                 pkC  Cg
  EFC39772.1 181 PKCNVCG 187
                 5677676 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       859  (0.0479112); expected 358.6 (0.02)
Passed bias filter:                      592  (0.0330191); expected 358.6 (0.02)
Passed Vit filter:                        55  (0.00306766); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.49
# Mc/sec: 1948.97
//
Query:       EFC39773.1  [L=555]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.069   13.7   0.1       0.15   12.6   0.1    1.5  1  PIGA      PIGA (GPI anchor biosynthesis)


Domain annotation for each model (and alignments):
>> PIGA  PIGA (GPI anchor biosynthesis)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.1   8.6e-06      0.15      29      72 ..     287     333 ..     272     337 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 8.6e-06
        PIGA  29 evtlptvlstlpllrnillreki...divhghqalstlaheailhak 72 
                 ++ l ++++ +p +++++++eki   div +h ++ tl + +i+++k
  EFC39773.1 287 KSLLENLFKLFPKCKHLVITEKIamlDIVNSHISARTLEKITIMYSK 333
                 678899***************9866689**********999999876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (555 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       748  (0.0417201); expected 358.6 (0.02)
Passed bias filter:                      320  (0.0178482); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.50
# Mc/sec: 3367.74
//
Query:       EFC39774.1  [L=647]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
  ------ inclusion threshold ------
      0.081   13.0   2.8       0.22   11.6   2.8    1.7  1  Duffy_binding  Duffy binding domain


Domain annotation for each model (and alignments):
>> Duffy_binding  Duffy binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   2.8   1.2e-05      0.22     104     153 ..     516     587 ..     490     609 .. 0.72

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.2e-05
  Duffy_binding 104 ekkkeekleenlkkifkkieeklkk......................nseklredwWeanreeiWkamtcal 153
                    ++++++++e+n+++  +  e++ ++                       ++++ ++wWe  r ++W+ +   +
     EFC39774.1 516 QSTTVNEIESNINENDNSVESTFNElesikeldtdsefdlfvknikeANNSKLNEWWESSRCQVWESIKKGV 587
                    4555566666665554444444444555777777888888888888777888999***********997665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (647 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1304  (0.0727313); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.74u 0.33s 00:00:01.07 Elapsed: 00:00:00.51
# Mc/sec: 3797.98
//
Query:       EFC39775.1  [L=583]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.8e-12   45.2   2.8    9.8e-12   45.2   2.8    2.7  3  RGS       Regulator of G protein signaling domain


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.2   2.8   5.4e-16   9.8e-12      11     118 .]      85     195 ..      81     195 .. 0.94
   2 ?   -0.8   0.1     0.096   1.7e+03      61      91 ..     230     259 ..     202     270 .. 0.72
   3 ?   -3.5   0.1      0.69   1.2e+04      60      79 ..     550     570 ..     528     574 .. 0.57

  Alignments for each domain:
  == domain 1  score: 45.2 bits;  conditional E-value: 5.4e-16
                 HHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS...STTTTTTHHHHHHHHHHHHHHHH CS
         RGS  11 grslFreFlesefseenlsFwlaveefkkakeqeelkkkakeIyneylapsspkelnidkklreelekrleke...qpsrklfeeaqeevfellekdsy 106
                  ++lF eFle e++   l+F ++ +efk  k+ +++ k  +e+++ y+++ s+++ln++++++e+  k + k    ++  ++f+ + ++++  l +d y
  EFC39775.1  85 FVQLFHEFLELEQNVMTLKFIFKLDEFKLLKSAKNRFKLGHELVDIYVKDCSANQLNLPNHVKENFMKEFAKCsikETPVTIFDPIFSHIHYSLGTDNY 183
                 579***********************************************************999999888877779999******************* PP

                 HHHHTSHHHHHH CS
         RGS 107 pkFlkselylrl 118
                  +F+ s+ly ++
  EFC39775.1 184 MRFVGSDLYAKF 195
                 *********886 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.096
                 TSTTSSTS-HHHHHHHHHHHCSSSTTTTTTH CS
         RGS  61 sspkelnidkklreelekrlekeqpsrklfe 91 
                 +++  l++++kl++ +++r ++ q s++ fe
  EFC39775.1 230 KMSDNLSLSDKLVQAIQDRESN-QVSNESFE 259
                 4456788999999999999777.88888887 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 0.69
                 TTSTTSS.TS-HHHHHHHHHH CS
         RGS  60 psspkel.nidkklreelekr 79 
                 +  +++  +id+++ +++ ++
  EFC39775.1 550 ERREQSTdSIDSQTINTIIDY 570
                 333334446777777776665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (583 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       663  (0.0369792); expected 358.6 (0.02)
Passed bias filter:                      321  (0.017904); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.45
# Mc/sec: 3883.74
//
Query:       EFC39776.1  [L=401]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      3e-14   53.3   0.0    5.3e-13   49.2   0.0    2.1  1  Abhydrolase_1    alpha/beta hydrolase fold
    5.7e-13   48.7   0.0    2.6e-12   46.5   0.0    1.9  1  Hydrolase_4      Serine aminopeptidase, S33
    2.3e-06   28.4   0.0    3.1e-06   28.0   0.0    1.2  1  Abhydrolase_6    Alpha/beta hydrolase family
     0.0024   17.5   0.0      0.078   12.5   0.0    2.4  2  DLH              Dienelactone hydrolase family
  ------ inclusion threshold ------
      0.019   14.4   0.0       0.17   11.3   0.0    2.1  2  Peptidase_S9     Prolyl oligopeptidase family
      0.063   13.2   0.0        0.1   12.5   0.0    1.2  1  BAAT_C           BAAT / Acyl-CoA thioester hydrolase C termin
       0.15   11.0   0.0       0.23   10.3   0.0    1.3  1  Chlorophyllase2  Chlorophyllase enzyme


Domain annotation for each model (and alignments):
>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.2   0.0   2.1e-16   5.3e-13       2     256 ..     101     388 ..     100     389 .. 0.81

  Alignments for each domain:
  == domain 1  score: 49.2 bits;  conditional E-value: 2.1e-16
                    EEEEE-STTTCGGGGTTGHHHHHHHHTTSEEEEEEETTSTTSSSTTTGB..............................CHHSHHHHHHHHH.HHH CS
  Abhydrolase_1   2 vlvilhGlpgssdvwaerglapaLakdgfdvillDlrGvgySspapacin.............................ddygtasvaddld.ril 67 
                    +l++ hG+p+s+ + ++r l   +++ g+ vi++D+rG+  Ss++  + +                             ++y ++ +a+d++  + 
     EFC39776.1 101 LLIFMHGYPESALLCYGRYLDHFIQQ-GYWVIAPDMRGYNTSSKPVPEGVdlkqinnglpseltfeslkkylqdlngiaNEYIDVKLAKDYQlLVT 195
                    79***************999999998.*******************99889****************************99***********5559 PP

                    HHCTTSSEEEEEETHHHHHHHHHHHHHGGGEEEEEEESECSSCCHHHHHHHHHHHHHHCHHCHHHHHHHHHHHHHHHHCCSCHHHHHHHHHHHHHH CS
  Abhydrolase_1  68 dalgddkltlvGhSmGGmialayaaeyperVkalvllgaidpaaslieaqrqqaksfpdffdgyaadcarnpagplladelaaleqrhrlvdalkf 163
                    +  +  k + + h++G ++ ++   eype + + vl  a             ++++  ++   ++ ++  ++   ++ + l+al +++ l  +++f
     EFC39776.1 196 EYAKRTKAIFISHDWGAATLTYTMREYPEIIEKAVLGVA-------------IRANQGKYIKENFGPFLTQVYKSWYVFFLQALGLSDYLFRKNDF 278
                    9**************************************.............77777888888888888888888888888888888777777777 PP

                    ........HCHHHCCHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHC...THHHHSEEEEEEETTCSSSCH.HHHHHHHHC.....HTSEEE CS
  Abhydrolase_1 164 ........pdkskrfpssgsdnasslatgalksieqwpttdsaklllrlre...lknvlaptlvisgtsDplvpp.kaledlaql.....lpkkrl 242
                             d ++r  + +   a+ + ++   s+ +++  +++++  +  +     +v++p+l++++++D++ ++  ++  l+++      +k+++
     EFC39776.1 279 afllnfgvFDEEGRKGRLSAEEAKFWLQNIRSSFTTATSFYRGAFRSQSKRsfdKEKVNVPVLFLHAENDRYLTEeTSQFALREAlteeaQKKSKV 374
                    887777884444444444444444444444444444444444444444333533366777***************9999999999655554449** PP

                    EEEETCSSSHHHHS CS
  Abhydrolase_1 243 vvisdagHlafleg 256
                    +++  + H++++ g
     EFC39776.1 375 FIVKESSHWVQFYG 388
                    ***********986 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   46.5   0.0     1e-15   2.6e-12       3     219 ..      98     370 ..      96     384 .. 0.83

  Alignments for each domain:
  == domain 1  score: 46.5 bits;  conditional E-value: 1e-15
  Hydrolase_4   3 pkavvvlvHGlaehsg.ryaelaeaLaaqGfavyalDhrGhGrse................gkrghvpsfddyvdDlaafv............ekvke 71 
                  ++++++++HG+ e++   y +  +++ +qG+ v+a D rG+  s                 +    ++s+++y++Dl+ +             + +++
   EFC39776.1  98 NQKLLIFMHGYPESALlCYGRYLDHFIQQGYWVIAPDMRGYNTSSkpvpegvdlkqinnglPSELTFESLKKYLQDLNGIAneyidvklakdyQLLVT 195
                  67899********98537999**************************************9999999************99878888888887767776 PP

  Hydrolase_4  72 ehpel.plfllGhSmGGliallyllrypdkvaglilsaPalkikaklkappllklllkllgkllpklqv...........................sn 141
                  e+ ++ + + + h +G+++ +  + +yp+ +++++l + a++ ++    + +++ +  +l +++++++v                            +
   EFC39776.1 196 EYAKRtKAIFISHDWGAATLTYTMREYPEIIEKAVL-GVAIRANQ---GKYIKENFGPFLTQVYKSWYVfflqalglsdylfrkndfafllnfgvfDE 289
                  665556***********************7777777.66666664...5789999***********************************99976633 PP

  Hydrolase_4 142 nlkadslsrdpevvaayeadplv.hgkitvrlllelldamkrleeraakitlPllllhGeaDkvvdpeas.....relyerlgs 219
                  +  +    r  ++ a++    +  ++++ +++++++++ +++   +++k+++P+l+lh+e+D+   +e s     ++l e++++
   EFC39776.1 290 EGRKG---RLSAEEAKFWLQNIRsSFTTATSFYRGAFRSQSKRSFDKEKVNVPVLFLHAENDRYLTEETSqfalrEALTEEAQK 370
                  33333...3444445566666666999****************************************99944443333344433 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.0   0.0   1.2e-09   3.1e-06       1     218 [.     102     392 ..     102     394 .. 0.48

  Alignments for each domain:
  == domain 1  score: 28.0 bits;  conditional E-value: 1.2e-09
                    EEEE--GC.....GC.HH.HHHHHHCCTCEEEEE--TTSTS-GGCS.................--HHHCHHHHHHHCCTT................ CS
  Abhydrolase_6   1 vlllHGagssassWl.va.pLaallaagvhvlapDlpGhGrsdppp.................ldledladlaalldelaa............... 62 
                    ++++HG  ++ s+ l ++  L  +  +g+ v+apD +G+  ++++p                 l++e l  +++ l+++a+               
     EFC39776.1 102 LIFMHG--YPESALLcYGrYLDHFIQQGYWVIAPDMRGYN-TSSKPvpegvdlkqinnglpseLTFESLKKYLQDLNGIANeyidvklakdyqllv 194
                    79****..555555444414444445557779*******6.3332234555555555555555555554333333333333444444445555555 PP

                    .....TTSEEEEEETCHHH.HHHHHHHCC...EE.EEES-...............----TTTS----TTHHHHHH............TT-CCCCHC CS
  Abhydrolase_6  63 ....gggpvvlvGHSlGGa.lalaaapla.lvvg.vlldp.............pptalpagllaaalelllalla............llrllawls 126
                         + +++ + H++G+a l    + ++ ++++ vl  +                        ++l+++ + +             l+r+     
     EFC39776.1 195 teyaKRTKAIFISHDWGAAtLTYTMREYPeIIEKaVLGVAiranqgkyikenfG----------PFLTQVYKSWYvfflqalglsdyLFRK----- 275
                    555588888********8844444444556444444444433344443332221..........222222211112222211112122222..... PP

                    CH..............S-HSCCCCHHHCCCCHCHCCCGHHHHCCHHCHTTCCHHTT-TTGC..........EEE.CTT-C.........HHHHCHH CS
  Abhydrolase_6 127 re..............plprlfladedadaawrarlarlaallaglgllpaaawadlpvpl..........lvl.ggeDp.........lvprlle 188
                     +               +  ++ a+e+    w ++ +    ++++++   + a++    +           l l +++D+         +    l+
     EFC39776.1 276 -NdfafllnfgvfdeeGRKGRLSAEEA--KFWLQNIRSSFTTATSFY---RGAFRSQSKRSfdkekvnvpvLFLhAENDRylteetsqfA----LR 361
                    .12333222223222234446666444..444444444443333333...2233333333334444444446664799998887744443....55 PP

                    CCCH...STTEEETCE...SSS-HHHHSHHHHH CS
  Abhydrolase_6 189 rlla...qagarlpvvlpgaGHlphleepdeva 218
                    ++l+   q + ++  +++ ++H++++   ++++
     EFC39776.1 362 EALTeeaQKKSKV-FIVKESSHWVQF-YGEKFI 392
                    5555554488888.**********99.877765 PP

>> DLH  Dienelactone hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.039        99      34      49 ..     121     136 ..     117     181 .. 0.82
   2 !   12.5   0.0     3e-05     0.078     124     187 ..     314     382 ..     302     394 .. 0.75

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.039
         DLH  34 erlaeeGYvalaPdlY 49 
                 + ++++GY ++aPd+ 
  EFC39776.1 121 DHFIQQGYWVIAPDMR 136
                 67899*********94 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 3e-05
         DLH 124 aavafYG...lspekeleeaakikapilalfgeeDefipade.vekleealk.aanvdlelkvYpgagH 187
                  a +fY     s +k+  + +k+++p+l+l++e+D   + ++    l+eal+ +a+++ ++ + ++  H
  EFC39776.1 314 TATSFYRgafRSQSKRSFDKEKVNVPVLFLHAENDRYLTEETsQFALREALTeEAQKKSKVFIVKESSH 382
                 556666547667777888999*****************9998433677776514566666666665555 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.13   3.4e+02      11      30 ..     124     143 ..     118     158 .. 0.81
   2 ?   11.3   0.0   6.7e-05      0.17     136     194 ..     330     390 ..     303     401 .] 0.74

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.13
                   HCCT-EEEEE--TTSSTTHC CS
  Peptidase_S9  11 adrGyvvvvanirGsggyGe 30 
                    ++Gy v+++++rG +  ++
    EFC39776.1 124 IQQGYWVIAPDMRGYNTSSK 143
                   489***********876665 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 6.7e-05
                   CGGG-----EEEEEEETT-SSS-THHH.HHHHHHHH.--S-SEEEEEETTS-SSTTSSHHH CS
  Peptidase_S9 136 pldnvkaypplLlihGlaDdrvppaea.lklvaaLq.kkgknvlllifpdegHgvgkprak 194
                     d+ k+++p+L++h+++D   + +++ + l +aL+ +++k++++ i +++ H+v+    k
    EFC39776.1 330 SFDKEKVNVPVLFLHAENDRYLTEETSqFALREALTeEAQKKSKVFIVKESSHWVQFYGEK 390
                   3455569************88866443256678999777888************9954444 PP

>> BAAT_C  BAAT / Acyl-CoA thioester hydrolase C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   3.9e-05       0.1     104     164 ..     326     385 ..     299     388 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 3.9e-05
                 GCCCB--GGG--SEEEEEEETT-SSS-HHHHHHHHHHHHHCTT--.--EEEEETTB-S--- CS
      BAAT_C 104 aekalipvekakgpillvvgedDknwpSkesaekaserLkkagkkvevqlltYpkaGHlie 164
                 ++k  ++ ek + p+l++ +e+D+ +  ++s   + e L+++ +k + ++ + +++ H ++
  EFC39776.1 326 QSKRSFDKEKVNVPVLFLHAENDRYLTEETSQFALREALTEEAQK-KSKVFIVKESSHWVQ 385
                 56788999*********************************9999.888888888888765 PP

>> Chlorophyllase2  Chlorophyllase enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   9.2e-05      0.23      19      57 ..     101     140 ..      94     183 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 9.2e-05
  Chlorophyllase2  19 vllflhGyl.llnslYsqlLkhiashgfivvapqlykvae 57 
                      +l+f+hGy      +Y + L h    g+ v+ap +   ++
       EFC39776.1 101 LLIFMHGYPeSALLCYGRYLDHFIQQGYWVIAPDMRGYNT 140
                      699*****978889*******************7665322 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (401 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       814  (0.0454013); expected 358.6 (0.02)
Passed bias filter:                      609  (0.0339673); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 2431.81
//
Query:       EFC39777.1  [L=386]
Description: RINGv domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-11   43.1   7.3    7.2e-11   42.0   7.3    1.6  1  RINGv     RING-variant domain


Domain annotation for each model (and alignments):
>> RINGv  RING-variant domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   42.0   7.3     4e-15   7.2e-11       1      48 []      68     118 ..      68     118 .. 0.88

  Alignments for each domain:
  == domain 1  score: 42.0 bits;  conditional E-value: 4e-15
                 ETTTTEE-SSSS--B-SS--STCCCSB-HHHHHHHHHH...TCT-SB-TTT CS
       RINGv   1 CriCleeeeeseplispCkCrGslklvHesClekWlde...keantqCeiC 48 
                 Cr C+   + +++ i pCkC+Gs+k+vH+ Cl++W +    +++   C+iC
  EFC39777.1  68 CRCCHGVLTANDDYIAPCKCTGSMKFVHRYCLDQWRSVspkASSFYACDIC 118
                 ***********************************999544444445***9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (386 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1280  (0.0713927); expected 358.6 (0.02)
Passed bias filter:                      519  (0.0289475); expected 358.6 (0.02)
Passed Vit filter:                        60  (0.00334653); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.30s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2390.22
//
Query:       EFC39778.1  [L=416]
Description: histone deacetylase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.1e-31  110.5   0.1    6.6e-31  107.9   0.1    2.2  1  Hist_deacetyl  Histone deacetylase domain
  ------ inclusion threshold ------
       0.13   12.1   0.0       0.26   11.2   0.0    1.4  1  NIL            NIL domain


Domain annotation for each model (and alignments):
>> Hist_deacetyl  Histone deacetylase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  107.9   0.1   7.3e-35   6.6e-31       9     280 ..      76     326 ..      68     371 .. 0.80

  Alignments for each domain:
  == domain 1  score: 107.9 bits;  conditional E-value: 7.3e-35
                    HHHHHHHHHT.THHHHCCE.EE-----HHHHTTTS-HHHHHHHHCHHHHCHHT.TTHCCHHHCCTSTSSSSSTHCTTTCCHHHHHHHHHHHHHHHH CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl   9 saileslaesvglldelelliqpseatkeellkvHskeYlelleslsnelkkkeeakekeleeiasklldddtpvspktlkaallavgavleavda 104
                    +++ ++l es  +l+  e +  p ++  + +++vH+ +++++  + + + k+ +        +i           ++ + + + +++ga+l a + 
     EFC39778.1  76 IQVPKALSESNAVLKT-E-IKVPDPIPIDLVKQVHDHDFVDKFLDGTISPKDMK--------RIGFG------EWNEAVRNRVIHTIGATLCATKD 155
                    4567778887666644.3.35777888888888999999888765443333332........22211......23456677778888999888888 PP

                    HHTTSSSEEEETTSS--TT-BTTB-BTTBSS-HHHHHHHHHHH..CC-.SS-EEEEE-SSS--HHHHHHCT..T-TTEEEEEEEE-CCTSTTSS-- CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxx.xxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 105 vlsgsvkaafvlvrPpgHHakaseasGFClvNnvaiaikylqa..khe.lkrvailDvDvHhGnGteeafy..sdpdvltlSiHryegifyPgtga 195
                     l+ + ++      ++gHH+  ++ sG+C+ N+++ia +yl +    +  ++ +++D+DvH+G+Gt+++++  ++ + +t+S+H   ++ +P + +
     EFC39778.1 156 ALNLNESRRSSNLAGGGHHSFYDRGSGYCIWNDIVIAGQYLINsgAIGeGRKYLVIDLDVHQGDGTSNLCRllHSGKSFTFSMHC--KHNFPIHKE 249
                    88776667777779******99*******************6645444368*******************977899*********..667**4333 PP

                    TT---SGGGTTSEEEEEE-TT-BHHHHHHHHHHCHHHHHCCH--..SEEEEEE-STTBTTSTT-S-BB-HHHHHHHHHHHCCCHGS- CS
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Hist_deacetyl 196 ledlgegkgkgfnlnvpleegtgdeeylkvfeeilrpvleefkP..dlilvsaGfDalkgdplgelnlsvegykeltkklaeladkv 280
                              ++ + v+le++++de+yl++++ +l  + +e++   d+i  + G+D l+gd+lg+l+ls eg+ +  +++ae+a+++
     EFC39778.1 250 ----------KSDWDVELEDNMKDETYLRILSDCLDTLEQEHRGkiDFIFFQSGVDVLQGDRLGRLSLSLEGVLKRDQMVAEFAERM 326
                    ..........35789**********************99999554499**********************************99864 PP

>> NIL  NIL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   2.9e-05      0.26      25      66 ..     284     325 ..     268     329 .. 0.80

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 2.9e-05
                 T-EEEEEEEEEEEETTEEEEEEEEEEES-HHHHHHHHHHHHH CS
         NIL  25 glevnIlqGsveriqgtpfGqlvielsgsqesiaaalqylrk 66 
                 ++++ + q +v+ +qg ++G+l ++l+g  ++ + + +++++
  EFC39778.1 284 KIDFIFFQSGVDVLQGDRLGRLSLSLEGVLKRDQMVAEFAER 325
                 68999*********************9966666666666665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (416 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       628  (0.0350271); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.63u 0.31s 00:00:00.94 Elapsed: 00:00:00.52
# Mc/sec: 2408.66
//
Query:       EFC39779.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0035   17.1   1.9      0.078   12.8   0.0    3.6  4  RCC1_2           Regulator of chromosome condensation (RCC1) 
  ------ inclusion threshold ------
      0.096   13.1   0.6        1.1    9.7   0.2    2.6  2  Imm45            Immunity protein 45
       0.11   11.3   0.0       0.17   10.8   0.0    1.2  1  Tyr-DNA_phospho  Tyrosyl-DNA phosphodiesterase


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0     0.087   5.2e+02       8      17 ..     123     132 ..     117     132 .. 0.80
   2 ?   -1.7   0.2      0.45   2.7e+03      17      26 ..     190     199 ..     182     202 .. 0.75
   3 !   12.8   0.0   1.3e-05     0.078       1      28 [.     223     250 ..     223     252 .. 0.94
   4 ?   -0.9   0.0      0.26   1.6e+03       6      16 ..     288     298 ..     286     300 .. 0.80

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.087
      RCC1_2   8 dyHscaLted 17 
                  +H+++L+ed
  EFC39779.1 123 TDHAIILMED 132
                 59******97 PP

  == domain 2  score: -1.7 bits;  conditional E-value: 0.45
      RCC1_2  17 dGeVlcWGsN 26 
                 + +++ +G+N
  EFC39779.1 190 NRDIHICGQN 199
                 5568889988 PP

  == domain 3  score: 12.8 bits;  conditional E-value: 1.3e-05
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsd 28 
                 V+s+ +G+++++a++ dG++++ GsN++
  EFC39779.1 223 VISLKSGNFFFIAVLKDGRIVSGGSNGY 250
                 89999********************987 PP

  == domain 4  score: -0.9 bits;  conditional E-value: 0.26
      RCC1_2   6 aGdyHscaLte 16 
                 +G+yH ++ t 
  EFC39779.1 288 SGNYHIFGRTK 298
                 8****988775 PP

>> Imm45  Immunity protein 45
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.2   0.0      0.16   9.7e+02      14      38 ..      39      63 ..      32      74 .. 0.82
   2 ?    9.7   0.2   0.00018       1.1      68      87 ..      76      95 ..      63     100 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.2 bits;  conditional E-value: 0.16
       Imm45 14 vlrvpgvyPyedevvdfivveaesa 38
                 +rv    P+ +++vd  v ++  +
  EFC39779.1 39 EVRVCCSEPFGKKIVDVNVKKMIRE 63
                5799999*********998887665 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00018
       Imm45 68 vvglstaWlienWqkwvYpe 87
                v +lst W+++ W +++Y  
  EFC39779.1 76 VSSLSTLWVMDRWSRKIYTI 95
                5789**************75 PP

>> Tyr-DNA_phospho  Tyrosyl-DNA phosphodiesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.8   0.0   2.8e-05      0.17     177     255 ..       9      92 ..       3     118 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 2.8e-05
                      HHTHHHHHTEE-GGGT-EEEEE---TTS--..........HHHHHHHHHHHTCT..T----EEEEEEE-SBB---S-.SSS---H CS
  Tyr-DNA_phospho 177 kklieklkkyDfsevrvaliaSvPgrhkgs......ktkwGlakLkkalkelplekeekskeleivaqvSSigslgstekwlkne 255
                      + l +klk  Df+e ++ +i S P +++++      ++ +G + +   +k++   + + +   ei + vSS+++l   ++w +++
       EFC39779.1   9 SLLSQKLKWDDFKEGQIDFIQSFPFQYQNEevrvccSEPFGKKIVDVNVKKMIR-EYNIPALREIGCIVSSLSTLWVMDRWSRKI 92 
                      567899999******************999999**9999999988888888866.45556688************9989998775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       550  (0.0306766); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 2755.45
//
Query:       EFC39780.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       515  (0.0287244); expected 358.6 (0.02)
Passed bias filter:                      312  (0.017402); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.37u 0.25s 00:00:00.62 Elapsed: 00:00:00.39
# Mc/sec: 1686.73
//
Query:       EFC39781.1  [L=269]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-30  105.0  20.1    1.7e-30  105.0  20.1    2.1  2  F_actin_bund_C  F actin bundling C terminal
  ------ inclusion threshold ------
          8    5.7   9.3        9.9    5.4   7.4    1.8  2  DUF4407         Domain of unknown function (DUF4407)


Domain annotation for each model (and alignments):
>> F_actin_bund_C  F actin bundling C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.4     0.036   3.2e+02      35      57 ..      62      84 ..      54      89 .. 0.78
   2 !  105.0  20.1   1.8e-34   1.7e-30       1      86 [.     164     249 ..     164     251 .. 0.96

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.036
  F_actin_bund_C 35 AkneLaqmkseDqlelnkaelta 57
                     +neL  ++++D l+ n    ta
      EFC39781.1 62 SQNELDEAQAADFLQKNGKTRTA 84
                    69**********99888655555 PP

  == domain 2  score: 105.0 bits;  conditional E-value: 1.8e-34
  F_actin_bund_C   1 ekAleefqaqkrareakmkeLeakaalgGVkgmaAkneLaqmkseDqlelnkaeltaeaakrkAeKavkeedalaekkkaaeeeee 86 
                     e+A++ef+aqkrare++ k+Le+k++l GVkg++AkneLaqm+s+Dq+e+nk+e+t++aakrkA K++++e++la+kkk++e ee+
      EFC39781.1 164 ENAISEFYAQKRARENRLKDLEEKSDLVGVKGLQAKNELAQMQSQDQTEMNKLEMTLNAAKRKALKNPSGEQLLAQKKKQQEDEEK 249
                     79***************************************************************************888887775 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0     0.059   5.3e+02     194     209 ..      61      81 ..      25     108 .. 0.57
   2 ?    5.4   7.4    0.0011       9.9     117     204 ..     164     257 ..     148     268 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.059
     DUF4407 194 aaqaelaelkakld......at 209
                   q+el+e++a  d      +t
  EFC39781.1  61 GSQNELDEAQAA-DflqkngKT 81 
                 233333333333.222221122 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0011
     DUF4407 117 qeeakelkeqlaaaltaelaeleaqia.............alqaeidaaearldalraeaqkeldgtkgtgttgvaGkgpaakekkaqldaaqaelael 202
                 +++++e+ +q + a +++l+      +             ++++e+++ +++ ++++++++  l+ +k +  ++  G+   a++kk+q d+ +++l+e 
  EFC39781.1 164 ENAISEFYAQKR-ARENRLK------DleeksdlvgvkglQAKNELAQMQSQDQTEMNKLEMTLNAAKRKALKNPSGEQLLAQKKKQQEDEEKKKLEEG 255
                 233333322222.2344444......244455599999999999999****999******999999999999999*****************9999986 PP

     DUF4407 203 ka 204
                 + 
  EFC39781.1 256 RL 257
                 55 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (269 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1707  (0.0952089); expected 358.6 (0.02)
Passed bias filter:                      392  (0.021864); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.29s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1601.82
//
Query:       EFC39782.1  [L=305]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (305 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       562  (0.0313459); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        16  (0.000892409); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.62u 0.32s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 1670.55
//
Query:       EFC39783.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-07   31.9  15.5    1.3e-07   31.9  15.5    3.6  3  EamA      EamA-like transporter family


Domain annotation for each model (and alignments):
>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.8  11.0         1   1.8e+04       2      56 ..     120     185 ..     119     300 .. 0.61
   2 ?   -0.9   4.6     0.096   1.7e+03       5      56 ..     249     302 ..     245     344 .. 0.64
   3 !   31.9  15.5     7e-12   1.3e-07      36     135 ..     350     452 ..     309     454 .. 0.86

  Alignments for each domain:
  == domain 1  score: -4.8 bits;  conditional E-value: 1
        EamA   2 lgillallaalfwaiyfvlskillrkv....spltltfvrfliagill........liiallkegkl 56 
                 lg+l ++ +  ++++ +++s++l ++     +p +l++ ++ +a++ll        li++l +++k+
  EFC39783.1 120 LGWLACISVHTLYGTHPIFSRYLQSQSpnkfPP-MLLVTSCHMAALLLysprilflLIVYLRNKWKN 185
                 688888999999999999999884444222133.444456666666665665544345555555554 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.096
        EamA   5 llallaalfwaiyfvls..killrkvspltltfvrfliagillliiallkegkl 56 
                 l+al + ++ a+ +v+   ++++r+ ++ +++++  +++ i+ +i  ++  +  
  EFC39783.1 249 LFALSSPFTLAFVTVFVynRWFIRDSHTKETFGLKAILSMIATFIGGAIIIIGS 302
                 556666666444444443388888888888888777777777766555544444 PP

  == domain 3  score: 31.9 bits;  conditional E-value: 7e-12
        EamA  36 vrfl.iagillliiallkegkl.aklslkdwllllllgllgtvlafllffyalkktsasnaslitslePvftlilsvlllgeklt.lkqllgivlillG 131
                 +++l + +i+ ++ a + +++l a+l+ kdw  ++ + +l  ++a++l + a+  +++++++ i++l  + t+++s+l+l+e+l+ ++qllg++++ll+
  EFC39783.1 350 YQLLiLVFIFAVPSAIFDDWTLwARLNSKDWGMFFGFTILVYMMANGLNILAIGLLGSTKVGSIIALRLISTIVFSSLILQESLKsIWQLLGCIIVLLS 448
                 6665478888899999999999**************************************************************6369*********** PP

        EamA 132 vlli 135
                 v + 
  EFC39783.1 449 VTYF 452
                 9875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1747  (0.0974399); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.74u 0.34s 00:00:01.08 Elapsed: 00:00:00.54
# Mc/sec: 2883.93
//
Query:       EFC39784.1  [L=575]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      1e-17   64.9   0.0    4.1e-17   63.0   0.0    2.0  2  VWA          von Willebrand factor type A domain
      9e-11   42.4   0.0    2.9e-10   40.7   0.0    1.9  1  VWA_2        von Willebrand factor type A domain
    1.9e-05   24.7   0.0    0.00018   21.5   0.0    2.1  2  VWA_3        von Willebrand factor type A domain
  ------ inclusion threshold ------
      0.028   14.9   0.2      0.082   13.4   0.2    1.7  1  Arrestin_C   Arrestin (or S-antigen), C-terminal domain
      0.043   13.9   1.2      0.045   13.8   0.1    1.7  2  DUF1013      Protein of unknown function (DUF1013)
      0.056   13.6   0.0       0.19   11.8   0.0    1.9  1  Ocnus        Janus/Ocnus family (Ocnus)
      0.059   13.2   0.2        3.5    7.5   0.0    2.9  3  MOZART1      Mitotic-spindle organizing gamma-tubulin ring as
      0.073   13.3   0.0       0.17   12.1   0.0    1.5  1  ASH          Abnormal spindle-like microcephaly-assoc'd, ASPM
       0.09   12.7   0.0       0.21   11.5   0.0    1.6  1  ChiC         Chitinase C
       0.12   12.3   0.3        3.6    7.5   0.1    2.6  2  RsgA_GTPase  RsgA GTPase


Domain annotation for each model (and alignments):
>> VWA  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.0   0.0   2.3e-20   4.1e-17       4     172 ..      36     197 ..      33     202 .. 0.91
   2 ?   -2.4   0.0       2.8     5e+03     111     132 ..     463     481 ..     440     519 .. 0.52

  Alignments for each domain:
  == domain 1  score: 63.0 bits;  conditional E-value: 2.3e-20
                 EEEE-STTSCHHHHHHHHHHHHHHHHHHTBTTTTEEEEEEEESSSEEEEEETTSHCHHHHHHHHHHTG.SGGGGSSC-HHHHHHHHHHHHHHHHGTSST CS
         VWA   4 fvlDgSgsmgeenfekvkefikklveklevgpegtrvglvqfssevktefslndysskeellsalnnl.kysgggttntgkalkyaleklfkssagaRe 101
                 ++ D+S sm ++   ++ +    +v++l  ++++ ++ ++ fss+  +++++ +  + +++l+++ ++ +   gg tn+g a ++al  + +++     
  EFC39784.1  36 ILGDTSPSMKDDSCCQMFSTTRGVVKQLHEQNKDNQFTIIEFSSKCAVHARVCS--DLDTILEKVPKVrTANLGGGTNLGGAFNEALIIIKNEMTD--- 129
                 677***********************************************9999..669********98555555555**********99999999... PP

                 TSEEEEEEEESS--CSS.HTHHHHHHHHGCTEEEEEEEESSSHHHHHHHHHSSSSCHHCEEEESSHHHHHHH CS
         VWA 102 nakkviilltdGksndg.dpkeaaneakeqgikvfavGvgnadekelLnkiasepgeghvftvtdfeeleel 172
                 + +k++ ++tdG ++d+ +  + an +k +++++ ++Gvg+  +k+++++i+  +g    +  +++++l+e+
  EFC39784.1 130 KRRKFLFVFTDGFPDDKiEAINRANDLKLANVDICCIGVGSGIDKSFIQTISPQKG----YHIQEWSKLNET 197
                 779***********9988**********************************9999....888888877765 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 2.8
                 ESS--CSSHTHHHHHHHHGCTE CS
         VWA 111 tdGksndgdpkeaaneakeqgi 132
                 + G+  d   ke ++++k+   
  EFC39784.1 463 AQGDRGD---KELIEKLKKMYQ 481
                 3344433...222222222222 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.7   0.0   1.6e-13   2.9e-10       6     106 ..      39     141 ..      34     142 .. 0.94

  Alignments for each domain:
  == domain 1  score: 40.7 bits;  conditional E-value: 1.6e-13
       VWA_2   6 DtSgSmrngdygptrleaakdaveallkslpgdrvglvtfsdgpevlipltkdkakilnalrnleak..gggtnlaaaLqlarkalkkrr.kgekrviv 101
                 DtS Sm ++    + +++ +  v++l +++++++++++ fs++  v++ +++d ++il+++ ++++   gggtnl+ a++ a  ++k++   ++++ ++
  EFC39784.1  39 DTSPSMKDD-SCCQMFSTTRGVVKQLHEQNKDNQFTIIEFSSKCAVHARVCSDLDTILEKVPKVRTAnlGGGTNLGGAFNEALIIIKNEMtDKRRKFLF 136
                 9*****996.5689***************************************************99*******************998889999**** PP

       VWA_2 102 litDg 106
                 ++tDg
  EFC39784.1 137 VFTDG 141
                 ****9 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.5   0.0     1e-07   0.00018       5     146 ..      36     181 ..      33     185 .. 0.83
   2 ?    0.4   0.0       0.3   5.4e+02      43      95 ..     437     486 ..     434     535 .. 0.63

  Alignments for each domain:
  == domain 1  score: 21.5 bits;  conditional E-value: 1e-07
       VWA_3   5 ivvDvsssmsaen.klvkdaLsvalrqLptnd...kiavllfgtkprplfpgsravsaaelqealqkike.lels.lgasnlegaLkeal...rqpakp 94 
                 i+ D+s sm++     + ++ + +++qL ++    +++++ f +k   +  ++r++s  +l+ +l+k+ + ++++  g++nl ga +eal   + +   
  EFC39784.1  36 ILGDTSPSMKDDScCQMFSTTRGVVKQLHEQNkdnQFTIIEFSSK---CAVHARVCS--DLDTILEKVPKvRTANlGGGTNLGGAFNEALiiiKNEMTD 129
                 99*******99989899999999****987763357999999999...9999**999..9******9977577776889*********99777677888 PP

       VWA_3  95 gevrsvilltDgssaqgeervsdlisrar.ekirfhalglgsslsaamlqaLA 146
                 +++++++++tDg ++ + e +  +  + + +++ + ++g gs +++  +q+++
  EFC39784.1 130 KRRKFLFVFTDGFPDDKIEAINRAN-DLKlANVDICCIGVGSGIDKSFIQTIS 181
                 99***********977774444444.444599**********99999999876 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.3
       VWA_3  43 gtkprplfpgsravsaaelqealqkikelelslgasnlegaLkealrqpakpg 95 
                  ++ + +++++ ++++ ++  +l+++++   ++g  +l   Lk+  +  +   
  EFC39784.1 437 EMSESIMTKQIEKCDENQVHCILFFLAQ--GDRGDKELIEKLKKMYQE-SLGY 486
                 5565666777888888888888888887..777888888888877764.2333 PP

>> Arrestin_C  Arrestin (or S-antigen), C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.2   4.6e-05     0.082       5      52 ..     210     257 ..     207     310 .. 0.74

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 4.6e-05
                 EEEEEEES-SEEETT--EEEEEEEEE-SSSEEEEEEEEEEEEEEEESS CS
  Arrestin_C   5 vsleaslpkkgyvpGetipvtvkidndskkkvkkikvslvqhvdvcaf 52 
                 v ++ +l  + y++Ge++++ v+i nds k++   +v   ++ +++++
  EFC39784.1 210 VRIKFTLKNRPYHIGENVKIMVTIINDSDKEIPAGTVIKFNRNSYFDS 257
                 78899999**********************987655555555555444 PP

>> DUF1013  Protein of unknown function (DUF1013)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   2.5e-05     0.045      53     132 ..      10      93 ..       1     100 [. 0.70
   2 ?   -4.2   0.1         9   1.6e+04      25      38 ..     441     454 ..     437     458 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.5e-05
     DUF1013  53 ekkkkgkrytpvskRqdkpdaiaw...llknhpelkdaqiakLvgtTketieairdrthwnsani.kpkdPvtlgLcsqkdLda 132
                 +++  +kr  p+ k++dk +  ++   l ++ p +kd   +++ +tT+  ++++ ++++ n+ +i +     ++     +dLd+
  EFC39784.1  10 SENDSTKRDRPMKKKTDKTHEAVHvgiLGDTSPSMKDDSCCQMFSTTRGVVKQLHEQNKDNQFTIiEFSSKCAVHARVCSDLDT 93 
                 3677788999*******986544323267899*************************999975541444444443333345555 PP

  == domain 2  score: -4.2 bits;  conditional E-value: 9
     DUF1013  25 qltreeiercekde 38 
                  + +++ie+c++++
  EFC39784.1 441 SIMTKQIEKCDENQ 454
                 56678899999887 PP

>> Ocnus  Janus/Ocnus family (Ocnus)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   0.00011      0.19      18      68 ..      59     110 ..      53     115 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00011
       Ocnus  18 ilikvkeeekeeekeivrglkkaeyhadifekveeelekl.glevkclGGGr 68 
                 ++ +++e++k+++ +i+   +k+++ha +  ++ + lek+ ++++  lGGG 
  EFC39784.1  59 VVKQLHEQNKDNQFTIIEFSSKCAVHARVCSDLDTILEKVpKVRTANLGGGT 110
                 566888999999***************************978********95 PP

>> MOZART1  Mitotic-spindle organizing gamma-tubulin ring associated
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       2.5   4.4e+03      32      38 ..     264     270 ..     263     273 .. 0.81
   2 ?    2.2   0.0     0.085   1.5e+02       6      20 ..     509     523 ..     505     524 .. 0.87
   3 ?    7.5   0.0     0.002       3.5      15      33 ..     543     561 ..     543     561 .. 0.92

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.5
     MOZART1  32 nGVnPea 38 
                 +GV+Pe+
  EFC39784.1 264 SGVDPES 270
                 79***97 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.085
     MOZART1   6 ilheiSqlLntgLDr 20 
                 ++ + S+lLn+++D+
  EFC39784.1 509 VIEQVSTLLNVNIDS 523
                 67889*******995 PP

  == domain 3  score: 7.5 bits;  conditional E-value: 0.002
     MOZART1  15 ntgLDretLsicvkLienG 33 
                 n  +D+etL i++kL ++G
  EFC39784.1 543 NFEIDKETLVILLKLFDKG 561
                 6789***********9988 PP

>> ASH  Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   9.6e-05      0.17      20      85 ..     222     289 ..     214     291 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.6e-05
                 --EEEEEEE-EEESS-SS-.-EEEEEEEE.--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
         ASH  20 kvGssaerlLtveNpseep.aevkvskvp.aaekgfsveetelevqpgesvtltvtwtPteegavrev 85 
                  +G++ +  +t+ N+s+++    +v k++ ++ +  +  +t+  v+p++s t+++++ P++  +vr++
  EFC39784.1 222 HIGENVKIMVTIINDSDKEiPAGTVIKFNrNSYFDSKTFKTKSGVDPESSATFEIELYPKDGATVRDI 289
                 68999************886444555555033334444445599*****************9999986 PP

>> ChiC  Chitinase C
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   0.00012      0.21      57      92 ..     230     266 ..     194     272 .. 0.77

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00012
        ChiC  57 klkitNnstktlPgGteleFdlpt.sapdnvkdqsgl 92 
                  ++i N s k++P+Gt ++F+  +   +++ k +sg+
  EFC39784.1 230 MVTIINDSDKEIPAGTVIKFNRNSyFDSKTFKTKSGV 266
                 45789***************97651456666777765 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.0   0.0     0.095   1.7e+02     105     121 ..     340     356 ..     321     386 .. 0.83
   2 ?    7.5   0.1     0.002       3.6      41      75 ..     482     516 ..     438     544 .. 0.74

  Alignments for each domain:
  == domain 1  score: 2.0 bits;  conditional E-value: 0.095
                  ECSTTSSHHHHHHHHCT CS
  RsgA_GTPase 105 vGqSGvGKStLinallp 121
                   G  G GKS++ n+++ 
   EFC39784.1 340 FGIIGSGKSSFFNRIVT 356
                  6888*********9976 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.002
                  HHHHTT-EEEEEEE-GGG--HHHHHHHHHHHHHHT CS
  RsgA_GTPase  41 laeekgiepvivlnKiDlleeeeeleelkeeleal 75 
                  +    g +p+++++K+D + e+e+ +++ e++++l
   EFC39784.1 482 ESLGYGYQPLVIVTKMDEVREQETKKQVIEQVSTL 516
                  44456789***************666665555443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (575 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       750  (0.0418317); expected 358.6 (0.02)
Passed bias filter:                      455  (0.0253779); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.64u 0.27s 00:00:00.91 Elapsed: 00:00:00.47
# Mc/sec: 3668.19
//
Query:       EFC39785.1  [L=409]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    4.5e-16   59.3   0.0    7.9e-16   58.5   0.0    1.4  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
    1.8e-09   37.1   0.0    2.8e-09   36.5   0.0    1.2  1  Polysacc_synt_2  Polysaccharide biosynthesis protein
    0.00018   21.4   0.0    0.00029   20.8   0.0    1.3  1  KR               KR domain
     0.0033   16.5   0.0     0.0051   15.9   0.0    1.3  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
     0.0099   15.4   0.0      0.015   14.8   0.0    1.3  1  Epimerase        NAD dependent epimerase/dehydratase family
  ------ inclusion threshold ------
      0.032   14.3   0.0       0.15   12.2   0.0    1.9  2  Shikimate_DH     Shikimate / quinate 5-dehydrogenase
        0.1   12.0   0.0       0.14   11.5   0.0    1.2  1  GDP_Man_Dehyd    GDP-mannose 4,6 dehydratase


Domain annotation for each model (and alignments):
>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.5   0.0   3.1e-19   7.9e-16       1     130 []      31     168 ..      31     168 .. 0.94

  Alignments for each domain:
  == domain 1  score: 58.5 bits;  conditional E-value: 3.1e-19
                      EEEE--.SHHHHHHHHHHHCTCCT-G..EEEEEESSHHHHHHHHCHH.......TTTCEEEEE--TTTHHHHHHHHHTTS..SEEEE-SSGG.. CS
  Sacchrp_dh_NADP   1 vliiGa.GsvGqavaellarhfdvda..eitvadrskeklealaaka.......lgvrfeaialdaenyeavLaallkeg..dlvvnlsppi.. 80 
                      vl++G+ Gs G+ ++  l + +dv +  ei++a+r+++++++  +++       +++r+++  +d++++++ L+  l+++   lv++  +p+  
       EFC39785.1  31 VLVLGGyGSFGKRITSQLFKDNDVNTpqEIVIAGRNLASANQFRDELiqntsssSSFRVQTSLVDVNDERS-LKDCLQQTkpNLVIHTCGPFqg 123
                      7999999*****************99**************9999999************************.********************99 PP

                      GHHHHHHHHHHHT-EEEESS-BCGCCSCHCCSHHHHHTHHHHHHCTSEEE CS
  Sacchrp_dh_NADP  81 ssldvlkaCietgvhyvdtsiskeertnyalreavlklkekakeagvtav 130
                      ++  v++ Ci++g++y+d s      +  ++ +   kl++ka ++ v av
       EFC39785.1 124 QNFHVAEQCIDRGINYIDLSD-----SREFVANFSDKLHDKAVKNDVLAV 168
                      999***************766.....666799999999999999988876 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.5   0.0   1.1e-12   2.8e-09       1      84 [.      31     117 ..      31     120 .. 0.91

  Alignments for each domain:
  == domain 1  score: 36.5 bits;  conditional E-value: 1.1e-12
                      EEEETTTSHHHHHHHHHHHHH....B-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT..T-SEEEE- CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkk....kpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrdkerlekaleelkvdvvfha 84 
                      vlv G+ Gs+G+++++q+ k     +p++i++  r+  +  ++++el +++++ + ++++ + + dv+d+++l+++l+++k+++v+h+
       EFC39785.1  31 VLVLGGYGSFGKRITSQLFKDndvnTPQEIVIAGRNLASANQFRDELIQNTSS-SSSFRVQTSLVDVNDERSLKDCLQQTKPNLVIHT 117
                      89****************997666689*******************8877766.4558889**************************7 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.8   0.0   1.1e-07   0.00029       3      88 ..      31     117 ..      30     147 .. 0.83

  Alignments for each domain:
  == domain 1  score: 20.8 bits;  conditional E-value: 1.1e-07
                 EEEETTTSHHHHHHHHHHHH....HHS-EEEEE-SS...--HHHHHHHHHHHHT.T-EEEE----TT-HHHHHHHHHHHHHHSS---EEEE- CS
          KR   3 ylitGGlGgLGlelarwlae....kgarhlvllsRs.aaadedskaliaeleal.gaevevvaaDvsdkdavealleeikaeeppikGviha 88 
                 +l+ GG+G++G+ ++ +l +    +  +++v+ +R+ a+a++  ++li++ +++   +v++  +Dv d+ +++ +l++ k +      vih+
  EFC39785.1  31 VLVLGGYGSFGKRITSQLFKdndvNTPQEIVIAGRNlASANQFRDELIQNTSSSsSFRVQTSLVDVNDERSLKDCLQQTKPNL-----VIHT 117
                 69*****************9555566899*******445566667899998887578********************998544.....4554 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0     2e-06    0.0051       1      81 [.      32     123 ..      32     140 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 2e-06
   3Beta_HSD   1 vvtGgaGFlGralvkeLvrlee...lkevrvlD......lrespelleelskvnvkk..viegDvtdkdkleealegvdvvihlaslvdvag 81 
                 +v+Gg G  G+++ ++L++ ++    +e+ ++        ++++el +++s++      +  +Dv+d+ +l++ l++ + ++++++  + +g
  EFC39785.1  32 LVLGGYGSFGKRITSQLFKDNDvntPQEIVIAGrnlasaNQFRDELIQNTSSSSSFRvqTSLVDVNDERSLKDCLQQTKPNLVIHTCGPFQG 123
                 69****************998833246777776886666444444444333333222348899**************998888887877777 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   5.8e-06     0.015       1      72 [.      31     118 ..      31     138 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 5.8e-06
                 EEEETTTSHHHHHHHHHHHHCT.....SEEEEEES-STTTTCHHCHHC...........EEEE--TT-HHHHHHHHHHHT-SEEEE-- CS
   Epimerase   1 ilVtGatGfiGsalvkallekg.....yevigldrlssasntarledl...........elveldltdrsalerlfkeeqpdavihlA 72 
                 +lV+G+ G  G+ ++ +l + +     +e++   r+  + n+ r+e +           +   +d+ d+ +l++ +++++p+ vih  
  EFC39785.1  31 VLVLGGYGSFGKRITSQLFKDNdvntpQEIVIAGRNLASANQFRDELIqntsssssfrvQTSLVDVNDERSLKDCLQQTKPNLVIHTC 118
                 79****************999999998885555555455555555555899*******9999************************84 PP

>> Shikimate_DH  Shikimate / quinate 5-dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   5.7e-05      0.15      12      62 ..      28      83 ..      16      98 .. 0.77
   2 ?   -0.8   0.0      0.58   1.5e+03      66     101 ..     153     188 ..     124     199 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 5.7e-05
                  T-EEEEES.-SHHHHHHHHHHHCC....T-CEEEEEESSHHHHHHHHHHHT.ET-E CS
  Shikimate_DH 12 ekkvlliG.aGemaelvakhLlak....gvkkvvvaNRtlerakelaeelkgeeie 62
                  + +vl++G  G  +++++++L +     + +++v+a+R+l+ a+++++el ++ ++
    EFC39785.1 28 SFRVLVLGgYGSFGKRITSQLFKDndvnTPQEIVIAGRNLASANQFRDELIQNTSS 83
                  5678888637***********9864333689******************9776554 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.58
                   GCGHHHHHHT-SEEEE-SSSSS-SB-HHHHHCCHHH CS
  Shikimate_DH  66 leelkellaeadvvisataseepilekeeveealkk 101
                    ++l++   ++dv+ ++ as+ p l+++ ++e+lk+
    EFC39785.1 153 SDKLHDKAVKNDVLAVCGASTVPGLSSAVLNEVLKH 188
                   466777777888888888888888877777777765 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   5.6e-05      0.14       1      81 [.      32     116 ..      32     126 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 5.6e-05
                    EEETTTSHHHHHHHHHHHHC....T-CCEEEEEEESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHHT-SEEEE CS
  GDP_Man_Dehyd   1 LiTGiaGfiGsylaelLlek....gyevhgivrrsssfntgriehlakdpkeeleenlklhkgDltDssslerllaevqpdevyn 81 
                    L+ G+ G  G  ++ +L +       + ++i  r+ + + +  ++l ++ +++ + +++   +D++D++sl++ l++++p+ v++
     EFC39785.1  32 LVLGGYGSFGKRITSQLFKDndvnTPQEIVIAGRNLASANQFRDELIQNTSSSSSFRVQTSLVDVNDERSLKDCLQQTKPNLVIH 116
                    78899999999999999987333223344455555555556778999999888888999*************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       491  (0.0273858); expected 358.6 (0.02)
Passed bias filter:                      476  (0.0265492); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.60u 0.26s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 2664.96
//
Query:       EFC39786.1  [L=401]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      3e-34  114.2  24.1    1.7e-05   24.5   0.0   11.4 11  LRR_6        Leucine Rich repeat
    4.9e-25   87.1  21.1    6.3e-08   32.3   0.3    5.6  6  LRR_8        Leucine rich repeat
      1e-15   57.6  43.2     0.0012   19.2   1.8    8.5  7  LRR_4        Leucine Rich repeats (2 copies)
      1e-06   28.4  17.5         20    6.2   0.0   10.2 12  LRR_1        Leucine Rich Repeat
    0.00078   19.3   0.3       0.58   10.0   0.1    4.3  5  DUF4347      Domain of unknown function (DUF4347)
  ------ inclusion threshold ------
      0.057   13.6   0.4        4.9    7.3   0.0    2.8  3  Mannitol_dh  Mannitol dehydrogenase Rossmann domain
      0.092   12.7   0.1       0.24   11.3   0.0    1.7  2  F-box-like   F-box-like
       0.14   12.0   0.5       0.38   10.7   0.2    1.9  2  F-box        F-box domain
       0.16   12.1   0.0        9.2    6.4   0.0    2.3  2  VirE_N       VirE N-terminal domain


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0      0.98   1.9e+03       7      16 ..     112     121 ..     110     123 .. 0.83
   2 !   15.6   0.3     6e-06     0.012       3      20 ..     132     149 ..     130     152 .. 0.91
   3 !    8.0   0.0    0.0017       3.3       4      23 ..     157     176 ..     154     177 .. 0.89
   4 !   16.7   0.0   2.6e-06    0.0052       4      23 ..     181     200 ..     178     201 .. 0.90
   5 !    6.0   0.0    0.0071        14       5      24 .]     206     225 ..     204     225 .. 0.94
   6 !    8.5   0.0    0.0012       2.3       5      17 ..     230     242 ..     227     244 .. 0.89
   7 !   11.2   0.1   0.00015       0.3       5      23 ..     276     294 ..     274     295 .. 0.92
   8 !   15.4   0.1   6.9e-06     0.014       4      23 ..     299     318 ..     296     319 .. 0.88
   9 !   24.5   0.0   8.7e-09   1.7e-05       4      24 .]     323     343 ..     320     343 .. 0.92
  10 !   12.3   0.1   6.7e-05      0.13       5      21 ..     348     364 ..     345     367 .. 0.87
  11 ?    2.7   0.0     0.086   1.7e+02       5      22 ..     372     388 ..     369     390 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.98
       LRR_6   7 eLdLsgNdIg 16 
                 +L++s N + 
  EFC39786.1 112 TLNVSENTFE 121
                 8******875 PP

  == domain 2  score: 15.6 bits;  conditional E-value: 6e-06
       LRR_6   3 thLteLdLsgNdIgDeGa 20 
                  hLt Ld+s N IgDeG+
  EFC39786.1 132 KHLTNLDISINLIGDEGV 149
                 6****************8 PP

  == domain 3  score: 8.0 bits;  conditional E-value: 0.0017
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L++s N Ig +Ga+ +
  EFC39786.1 157 QLTNLNISNNMIGEKGAQYI 176
                 59**************9876 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 2.6e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L++++N+Ig eG++ L
  EFC39786.1 181 QLTCLNINSNHIGSEGVKFL 200
                 59***************966 PP

  == domain 5  score: 6.0 bits;  conditional E-value: 0.0071
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L++Ld+ ++ Ig +Ga+ L+
  EFC39786.1 206 LRTLDMVYCYIGEVGAKYLS 225
                 9***************9885 PP

  == domain 6  score: 8.5 bits;  conditional E-value: 0.0012
       LRR_6   5 LteLdLsgNdIgD 17 
                 Lt+Ld+ +N+I++
  EFC39786.1 230 LTHLDVECNNING 242
                 9**********85 PP

  == domain 7  score: 11.2 bits;  conditional E-value: 0.00015
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L+++ N+I+ +Ga+ +
  EFC39786.1 276 LTDLNVANNGISAKGAKFI 294
                 99**************977 PP

  == domain 8  score: 15.4 bits;  conditional E-value: 6.9e-06
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  L  L++ +N+Ig eGa+ +
  EFC39786.1 299 RLVNLNIGHNNIGKEGAKFI 318
                 6889*************977 PP

  == domain 9  score: 24.5 bits;  conditional E-value: 8.7e-09
       LRR_6   4 hLteLdLsgNdIgDeGaeaLa 24 
                 +Lt Ld+s+N I+DeGa++++
  EFC39786.1 323 KLTCLDISCNSIQDEGAKCIS 343
                 8*****************996 PP

  == domain 10  score: 12.3 bits;  conditional E-value: 6.7e-05
       LRR_6   5 LteLdLsgNdIgDeGae 21 
                 Lt+L++++N+I+ +Ga 
  EFC39786.1 348 LTSLNINSNNINKKGAN 364
                 9**************95 PP

  == domain 11  score: 2.7 bits;  conditional E-value: 0.086
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+L +++N IgD Ga  
  EFC39786.1 372 LTYLKIRFN-IGDNGARN 388
                 888888887.99999865 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.1   3.2   0.00052         1       3      61 .]      85     144 ..      83     144 .. 0.87
   2 !   26.7   2.1   1.7e-09   3.4e-06       2      61 .]     133     192 ..     132     192 .. 0.98
   3 !   20.8   0.0   1.2e-07   0.00024       2      59 ..     205     261 ..     204     263 .. 0.95
   4 !   12.5   1.9   4.7e-05     0.093      21      61 .]     270     310 ..     261     310 .. 0.75
   5 !   13.6   1.0   2.2e-05     0.044       3      52 ..     276     325 ..     274     327 .. 0.84
   6 !   32.3   0.3   3.1e-11   6.3e-08       2      59 ..     323     380 ..     322     380 .. 0.97

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.00052
                 -SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  +sL +++ + + + d + F+ ++   +L+ s+N+ +  + + + +L++L+ Ld+s N +
  EFC39786.1  85 IQSLTVNRRNrIIAFDCQLFNLMKDISTLNVSENTFENGHCKYIGQLKHLTNLDISINLI 144
                 566667654449999****************************************99876 PP

  == domain 2  score: 26.7 bits;  conditional E-value: 1.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+Ld+s N + + + +  ++l++L+ L++snN +    ++ +  +++L+ L++++N++
  EFC39786.1 133 HLTNLDISINLIGDEGVGYLRKLKQLTNLNISNNMIGEKGAQYIGKMKQLTCLNINSNHI 192
                 8*********************************************************98 PP

  == domain 3  score: 20.8 bits;  conditional E-value: 1.2e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +L++Ld    ++ +++ +  + +++L++Ld  +N+++   ++ +  L+ L++L+  +N
  EFC39786.1 205 ELRTLDMVYCYIGEVGAKYLSEMKQLTHLDVECNNINGG-AKYLGELKELTYLNAKYN 261
                 79************************************9.7*************9998 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 4.7e-05
                 STT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  21 FkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                  ++l+ L+ L+  nN ++   ++ +s +++L  L++ +N++
  EFC39786.1 270 LSRLELLTDLNVANNGISAKGAKFISEMNRLVNLNIGHNNI 310
                 56777888888888888888888888888888888888876 PP

  == domain 5  score: 13.6 bits;  conditional E-value: 2.2e-05
                 -SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-. CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLr 52 
                 Lt L++ nN +++ + ++ + +++L  L++++N++    ++ +s++++L+
  EFC39786.1 276 LTDLNVANNGISAKGAKFISEMNRLVNLNIGHNNIGKEGAKFISQMKKLT 325
                 899999999999999999999************99877666666666665 PP

  == domain 6  score: 32.3 bits;  conditional E-value: 3.1e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgN 59 
                 +Lt Ld+s+N++++ + ++ + +++L++L++++N+++   ++ ++ +++L++L ++ N
  EFC39786.1 323 KLTCLDISCNSIQDEGAKCISEMKQLTSLNINSNNINKKGANYIAEMNQLTYLKIRFN 380
                 7999**************************************************9988 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.8   1.3     0.041        81       1      33 [.      83     118 ..      63     123 .. 0.78
   2 !   19.2   1.8   6.2e-07    0.0012       1      36 [.     132     168 ..     132     171 .. 0.88
   3 !   17.0   0.0   2.9e-06    0.0058       1      38 [.     180     218 ..     180     222 .. 0.85
   4 !    6.6   0.0    0.0055        11      19      36 ..     224     240 ..     216     252 .. 0.78
   5 !    9.7   0.4   0.00059       1.2       2      36 ..     252     286 ..     251     296 .. 0.89
   6 !   16.2   0.3   5.4e-06     0.011       2      37 ..     299     335 ..     298     339 .. 0.82
   7 !   14.3   8.3   2.1e-05     0.042       1      35 [.     322     358 ..     322     397 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.8 bits;  conditional E-value: 0.041
                 SS--EEE--.SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLs.nNqltdipl..leklpnLkeLdLsgN 33 
                 +n ++L  +  N++  ++   ++ +++  +L++s+N
  EFC39786.1  83 QNIQSLTVNrRNRIIAFDCqlFNLMKDISTLNVSEN 118
                 477777788778877766663444888999999888 PP

  == domain 2  score: 19.2 bits;  conditional E-value: 6.2e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++Ld+s N + d +   l+kl++L+ L++s+N  i
  EFC39786.1 132 KHLTNLDISINLIGDEGVgyLRKLKQLTNLNISNN-MI 168
                 68*******88****9999999**********665.55 PP

  == domain 3  score: 17.0 bits;  conditional E-value: 2.9e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L+ L++++N++ + +   l+ l+ L++Ld+  + +i+ 
  EFC39786.1 180 KQLTCLNINSNHIGSEGVkfLKELKELRTLDMVYC-YIGE 218
                 589***********998895555*********888.7765 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.0055
                 HHH-TT--EEE-.-S--- CS
       LRR_4  19 leklpnLkeLdLsgNnli 36 
                 l+ +++L++Ld+ ++n+i
  EFC39786.1 224 LSEMKQLTHLDV-ECNNI 240
                 4559*******9.55555 PP

  == domain 5  score: 9.7 bits;  conditional E-value: 0.00059
                 S--EEE--SS---.E-S-HHH-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqlt.diplleklpnLkeLdLsgNnli 36 
                  L++L+   N l  d+  l+ l  L+ L++  Nn i
  EFC39786.1 252 ELTYLNAKYNILGdDVRYLSRLELLTDLNV-ANNGI 286
                 7************99999888*********.66676 PP

  == domain 6  score: 16.2 bits;  conditional E-value: 5.4e-06
                 S--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 +L +L++++N++ + +   ++++++L+ Ld+s N  i+
  EFC39786.1 299 RLVNLNIGHNNIGKEGAkfISQMKKLTCLDISCN-SIQ 335
                 5889*********999995446*********555.554 PP

  == domain 7  score: 14.3 bits;  conditional E-value: 2.1e-05
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S-- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnl 35 
                 ++L+ Ld+s N ++d +   ++ +++L++L++++Nn 
  EFC39786.1 322 KKLTCLDISCNSIQDEGAkcISEMKQLTSLNINSNNI 358
                 69*******99****99996445*********88842 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0         9   1.8e+04       4      12 ..     112     120 ..     111     128 .. 0.70
   2 ?   -1.0   0.1       2.4   4.8e+03       2      12 ..     134     144 ..     130     155 .. 0.59
   3 ?    4.1   0.0     0.052     1e+02       2      20 ..     158     176 ..     157     179 .. 0.77
   4 ?    3.6   0.2     0.075   1.5e+02       2      20 ..     182     200 ..     181     203 .. 0.76
   5 ?    2.0   0.0      0.24   4.8e+02       2      16 ..     206     220 ..     205     227 .. 0.77
   6 ?    4.5   0.0     0.038        76       1      14 [.     229     241 ..     229     251 .. 0.76
   7 ?   -1.0   0.0       2.4   4.7e+03       2      15 ..     253     265 ..     252     274 .. 0.74
   8 ?   -1.4   0.0       3.3   6.6e+03       2      13 ..     276     287 ..     275     296 .. 0.76
   9 ?    1.8   0.0      0.28   5.6e+02       2      13 ..     300     311 ..     299     320 .. 0.75
  10 ?    6.2   0.0      0.01        20       1      21 [.     323     343 ..     323     345 .. 0.89
  11 ?    6.2   0.0     0.011        21       1      20 [.     347     366 ..     347     369 .. 0.83
  12 ?    0.3   0.1      0.88   1.7e+03       2      12 ..     372     382 ..     371     400 .. 0.67

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 9
       LRR_1   4 hLdLsnnpl 12 
                 +L++s n +
  EFC39786.1 112 TLNVSENTF 120
                 688887765 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2.4
       LRR_1   2 LrhLdLsnnpl 12 
                 L+ Ld+s n +
  EFC39786.1 134 LTNLDISINLI 144
                 55567775555 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.052
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ L++snn ++ ++++++
  EFC39786.1 158 LTNLNISNNMIGEKGAQYI 176
                 899******9977766665 PP

  == domain 4  score: 3.6 bits;  conditional E-value: 0.075
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ L++++n++++ +   +
  EFC39786.1 182 LTCLNINSNHIGSEGVKFL 200
                 899*******977666555 PP

  == domain 5  score: 2.0 bits;  conditional E-value: 0.24
       LRR_1   2 LrhLdLsnnpllglp 16 
                 Lr+Ld+ ++ ++  +
  EFC39786.1 206 LRTLDMVYCYIGEVG 220
                 9********986555 PP

  == domain 6  score: 4.5 bits;  conditional E-value: 0.038
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L+hLd++ n++ +
  EFC39786.1 229 QLTHLDVECNNI-N 241
                 59*****99987.3 PP

  == domain 7  score: -1.0 bits;  conditional E-value: 2.4
       LRR_1   2 LrhLdLsnnpllgl 15 
                 L++L+  +n+l g 
  EFC39786.1 253 LTYLNAKYNIL-GD 265
                 89999999999.44 PP

  == domain 8  score: -1.4 bits;  conditional E-value: 3.3
       LRR_1   2 LrhLdLsnnpll 13 
                 L+ L++ nn ++
  EFC39786.1 276 LTDLNVANNGIS 287
                 677999999875 PP

  == domain 9  score: 1.8 bits;  conditional E-value: 0.28
       LRR_1   2 LrhLdLsnnpll 13 
                 L  L++++n+++
  EFC39786.1 300 LVNLNIGHNNIG 311
                 6779*****984 PP

  == domain 10  score: 6.2 bits;  conditional E-value: 0.01
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L+ Ld+s n++ + ++ +++
  EFC39786.1 323 KLTCLDISCNSIQDEGAKCIS 343
                 7999********999999987 PP

  == domain 11  score: 6.2 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L++++n++  +++n++
  EFC39786.1 347 QLTSLNINSNNINKKGANYI 366
                 599****9999988888776 PP

  == domain 12  score: 0.3 bits;  conditional E-value: 0.88
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L ++ n++
  EFC39786.1 372 LTYLKIRFNIG 382
                 89999988886 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.12   2.4e+02     103     129 ..     145     169 ..     144     175 .. 0.82
   2 !   10.0   0.1   0.00029      0.58      56     139 ..     169     253 ..     151     262 .. 0.78
   3 ?   -1.5   0.0      0.98   1.9e+03     102     121 ..     286     305 ..     279     313 .. 0.82
   4 ?    2.1   0.0     0.079   1.6e+02     103     123 ..     311     331 ..     308     340 .. 0.87
   5 ?   -0.1   0.0      0.36   7.2e+02     103     124 ..     335     356 ..     330     366 .. 0.81

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.12
     DUF4347 103 geaGeafvekLaqltgadvaAstdltG 129
                 g++G  +++kL+qlt+ ++  s++ +G
  EFC39786.1 145 GDEGVGYLRKLKQLTNLNI--SNNMIG 169
                 68999***********999..555666 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 0.00029
     DUF4347  56 GsegalqLgnt.elnaenlekya..eelaqwgealsedadillYgCnvAageaGeafvekLaqltgadvaAstdltGnaalggdWeL 139
                 G++ga ++g+  +l+  n+++++  +e  ++ ++l+e +++ +  C +++   G +++++++qlt+ dv  ++   G++ lg   eL
  EFC39786.1 169 GEKGAQYIGKMkQLTCLNINSNHigSEGVKFLKELKELRTLDMVYCYIGEV--GAKYLSEMKQLTHLDVECNNINGGAKYLGELKEL 253
                 899999999977999999998664555556679999999**9999**9875..*****************99999888888865555 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 0.98
     DUF4347 102 ageaGeafvekLaqltgadv 121
                  +++G +f++++++l++ ++
  EFC39786.1 286 ISAKGAKFISEMNRLVNLNI 305
                 46799*********999887 PP

  == domain 4  score: 2.1 bits;  conditional E-value: 0.079
     DUF4347 103 geaGeafvekLaqltgadvaA 123
                 g++G +f++++++lt  d++ 
  EFC39786.1 311 GKEGAKFISQMKKLTCLDISC 331
                 678*************99975 PP

  == domain 5  score: -0.1 bits;  conditional E-value: 0.36
     DUF4347 103 geaGeafvekLaqltgadvaAs 124
                 +++G + +++++qlt  ++ ++
  EFC39786.1 335 QDEGAKCISEMKQLTSLNINSN 356
                 4689999********9999865 PP

>> Mannitol_dh  Mannitol dehydrogenase Rossmann domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.3   0.0    0.0025       4.9      11      77 ..     120     185 ..     117     235 .. 0.81
   2 ?   -0.6   0.0      0.68   1.4e+03      18      76 ..     199     255 ..     193     299 .. 0.54
   3 ?    3.1   0.1      0.05     1e+02      25      90 ..     300     364 ..     285     386 .. 0.69

  Alignments for each domain:
  == domain 1  score: 7.3 bits;  conditional E-value: 0.0025
                  HHHHTHHHHHHHHTT--TT-EEEEEE-STTHHHHHHHTTTT-EEEEE-SSS---EEEE--EEEEEEG CS
  Mannitol_dh  11 fhRahqayiddLlaeegldwgivevnlrevdareaLkaqdelyvviekgeeskearlvgsvnavlsv 77 
                  f  +h  yi++L + ++ld++i  ++++ v    +Lk+  +l++   +  ++k a+ +g+++++   
   EFC39786.1 120 FENGHCKYIGQLKHLTNLDISINLIGDEGVGYLRKLKQLTNLNISNNM-IGEKGAQYIGKMKQLTCL 185
                  677999************************997888888888877777.99999999***9987544 PP

  == domain 2  score: -0.6 bits;  conditional E-value: 0.68
                  HHHHHHTT--TT-EEEEEE-STTHHHHHHHTTTT-EEEEE-SSS---EEEE--EEEEEE CS
  Mannitol_dh  18 yiddLlaeegldwgivevnlrevdareaLkaqdelyvviekgeeskearlvgsvnavls 76 
                  ++++L +   ld+ ++ +++  ++  +++k+  +l v+  +   +  a+  g+++++ +
   EFC39786.1 199 FLKELKELRTLDMVYCYIGEVGAKYLSEMKQLTHLDVECNN--INGGAKYLGELKELTY 255
                  66666666777777777777777776666666666666555..3333333333333333 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.05
                  T--TT-EEEEEE-STTHHHHHHHTTTT-EEEEE-SSS---EEEE--EEEEEEGGG-HHHHHHHHTS CS
  Mannitol_dh  25 eegldwgivevnlrevdareaLkaqdelyvviekgeeskearlvgsvnavlsveedlealieamae 90 
                    +l++g  +++++ +++++++k+  +l +   +  +++ a+ +++++++ s + + +++ ++ a+
   EFC39786.1 300 LVNLNIGHNNIGKEGAKFISQMKKLTCLDISCNS-IQDEGAKCISEMKQLTSLNINSNNINKKGAN 364
                  4556666666666666667777777777777776.7777777777777777777766666666555 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00012      0.24       6      35 ..      31      62 ..      31      67 .. 0.85
   2 ?   -3.1   0.0       3.9   7.7e+03      27      41 ..      90     103 ..      88     105 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00012
  F-box-like  6 dEiLlqIFsyL.ppsdLlr.lalVCrrWrrva 35
                +++L +I+s+L +++ ++  ++lV+++++++ 
  EFC39786.1 31 NDVLYEILSFLdDFKFIVTtCTLVSSQFANIS 62
                689********889955555********9986 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 3.9
  F-box-like  27 VCrrWrrvaldtplL 41 
                 V rr r +a+d+ +L
  EFC39786.1  90 VNRRNRIIAFDC-QL 103
                 778889999999.77 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.2   0.00019      0.38       6      44 ..      29      69 ..      25      73 .. 0.91
   2 ?   -2.6   0.0       2.8   5.7e+03      12      19 ..     387     394 ..     387     395 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00019
                S-HHHHHHHHHTS-HHH..HHHHCTT-HHHHHHHTTHHHHH CS
       F-box  6 LPsevlrhILerLplsd..llalrrVSkgwrilidsdrlwc 44
                 +++vl +IL++L+     +  + +VS  + ++ ++++l +
  EFC39786.1 29 FSNDVLYEILSFLDDFKfiVTTCTLVSSQFANISKKLKLSL 69
                589********************************999866 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 2.8
                 HHHHHTS- CS
       F-box  12 rhILerLp 19 
                 r+IL++Lp
  EFC39786.1 387 RNILKQLP 394
                 79***998 PP

>> VirE_N  VirE N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.4   0.0    0.0046       9.2       5      76 ..     157     228 ..     153     252 .. 0.87
   2 ?    3.4   0.0     0.039        77      19      81 ..     289     351 ..     282     379 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0046
      VirE_N   5 klpavtpaaefsggrkekklkkynglvvlDidhlaskeeaeelrrllkedpqtllaFvspsgrGvKifvrie 76 
                 +l  + ++ ++ g+++++ + k+ +l +l i+  +  +e ++++++lke+  + ++++ + + G K +  ++
  EFC39786.1 157 QLTNLNISNNMIGEKGAQYIGKMKQLTCLNINSNHIGSEGVKFLKELKELRTLDMVYCYIGEVGAKYLSEMK 228
                 666677788889999****************9888879***************9999999999998877666 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.039
      VirE_N  19 rkekklkkynglvvlDidhlaskeeaeelrrllkedpqtllaFvspsgrGvKifvrierpdge 81 
                 +++k + ++n+lv l i h +  +e +++  ++k++  + ++  s++ +G K +  +++ ++ 
  EFC39786.1 289 KGAKFISEMNRLVNLNIGHNNIGKEGAKFISQMKKLTCLDISCNSIQDEGAKCISEMKQLTSL 351
                 567889999**********9999999*************99999*****99999988876554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (401 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       688  (0.0383736); expected 358.6 (0.02)
Passed bias filter:                      367  (0.0204696); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.59u 0.34s 00:00:00.93 Elapsed: 00:00:00.49
# Mc/sec: 2466.49
//
Query:       EFC39787.1  [L=1116]
Description: GAL4 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    8.2e-09   35.4  13.6    8.2e-09   35.4  13.6    1.7  2  Zn_clus   Fungal Zn(2)-Cys(6) binuclear cluster domain


Domain annotation for each model (and alignments):
>> Zn_clus  Fungal Zn(2)-Cys(6) binuclear cluster domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.4  13.6   4.6e-13   8.2e-09       2      39 ..     344     381 ..     343     382 .. 0.89
   2 ?   -3.7   0.5       0.8   1.4e+04       8      15 ..     495     502 ..     494     507 .. 0.63

  Alignments for each domain:
  == domain 1  score: 35.4 bits;  conditional E-value: 4.6e-13
                 S-HHHHHCT---STSSSS-HHHHHCTHHHCCCCTCCCE CS
     Zn_clus   2 aCdnCrkkKvKCdakkPaCsnCkklnleCtfysesskr 39 
                 aC++Cr ++ +Cd+k P+Cs C+k +l+C++ + +++r
  EFC39787.1 344 ACTRCRERHKRCDRKLPQCSYCEKQGLQCVYTTPKKQR 381
                 9*****************************55555555 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 0.8
                 HCT---ST CS
     Zn_clus   8 kkKvKCda 15 
                 k+K+ C+ 
  EFC39787.1 495 KRKSSCET 502
                 66777754 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1116 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2308  (0.12873); expected 358.6 (0.02)
Passed bias filter:                      307  (0.0171231); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 1.24u 0.37s 00:00:01.61 Elapsed: 00:00:00.59
# Mc/sec: 5728.09
//
Query:       EFC39788.1  [L=131]
Description: Hypothetical protein NAEGRDRAFT_72432 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.7e-10   40.0   0.0    5.3e-10   39.0   0.0    1.5  2  F-box-like  F-box-like
    6.4e-05   22.7   0.3    0.00052   19.8   0.0    2.5  2  F-box       F-box domain
  ------ inclusion threshold ------
       0.11   12.1   0.0       0.64    9.6   0.0    2.4  2  F-box_5     F-box


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.0   0.0   8.9e-14   5.3e-10       2      47 ..       3      49 ..       2      50 .. 0.89
   2 ?   -3.7   0.0         2   1.2e+04      30      37 ..      60      67 ..      59      68 .. 0.74

  Alignments for each domain:
  == domain 1  score: 39.0 bits;  conditional E-value: 8.9e-14
  F-box-like  2 srLPdEiLlqIFsy.Lp.psdLlrlalVCrrWrrvaldtplLWrrlvl 47
                ++LP+Ei+ qIF++ ++ p+++l+ ++VC++++++  +t  +W ++ l
  EFC39788.1  3 DSLPNEIIEQIFEFgIEiPQEILSHSRVCKQFYEILENT-KMWENVKL 49
                79**********985544889*****************9.***99865 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 2
  F-box-like 30 rWrrvald 37
                rW +++++
  EFC39788.1 60 RWSQLISN 67
                78888865 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.8   0.0   8.7e-08   0.00052       3      43 ..       2      44 ..       2      47 .. 0.86
   2 ?   -2.8   0.0       1.1   6.6e+03       2      11 ..      60      69 ..      59      76 .. 0.54

  Alignments for each domain:
  == domain 1  score: 19.8 bits;  conditional E-value: 8.7e-08
                HHHS-HHHHHHHHHTS-HHH....HHHHCTT-HHHHHHHTTHHHH CS
       F-box  3 lsrLPsevlrhILerLplsd....llalrrVSkgwrilidsdrlw 43
                l++LP+e++++I+e+   ++    +l+ +rV+k ++ ++ + + w
  EFC39788.1  2 LDSLPNEIIEQIFEF--GIEipqeILSHSRVCKQFYEILENTKMW 44
                579************..44446****************9987776 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.1
                HHHHS-HHHH CS
       F-box  2 tlsrLPsevl 11
                 +s+L s  +
  EFC39788.1 60 RWSQLISNPI 69
                5666655444 PP

>> F-box_5  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.6   0.0   0.00011      0.64       4      35 ..       5      37 ..       2      42 .. 0.75
   2 ?   -2.2   0.0      0.53   3.2e+03      16      22 ..      65      71 ..      63      79 .. 0.67

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 0.00011
                -GGGTHHHHHCC.---HHHHHHHTTS-HHHHHH CS
     F-box_5  4 fpDeVlecVlpy.itsprDRnAvSlVCkrWYei 35
                +p+e++e+++++ i+ p+   + S VCk+ Yei
  EFC39788.1  5 LPNEIIEQIFEFgIEIPQEILSHSRVCKQFYEI 37
                56677777777666667777788********98 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 0.53
                ---HHHH CS
     F-box_5 16 itsprDR 22
                i++p DR
  EFC39788.1 65 ISNPIDR 71
                5566665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (131 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      489  (0.0272742); expected 358.6 (0.02)
Passed Vit filter:                        44  (0.00245412); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.35s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 728.09
//
Query:       EFC39789.1  [L=529]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.9e-36  122.4   8.1    4.5e-06   26.5   0.2    9.1  9  Arm              Armadillo/beta-catenin-like repeat
    7.7e-09   35.9   0.1      0.072   13.6   0.0    5.2  5  HEAT_EZ          HEAT-like repeat
    0.00024   21.3   2.2        5.3    7.4   0.0    5.7  7  RICTOR_V         Rapamycin-insensitive companion of mTOR, dom
      0.002   18.1   0.2          1    9.4   0.0    3.1  3  Atx10homo_assoc  Spinocerebellar ataxia type 10 protein domai
  ------ inclusion threshold ------
       0.14   12.1   0.0       0.77    9.7   0.0    2.1  2  Phage_NinH       Phage NinH protein
       0.22   11.4   0.2       0.22   11.4   0.2    2.1  3  DUF4868          Domain of unknown function (DUF4868)


Domain annotation for each model (and alignments):
>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.0     0.057   1.7e+02       1      24 [.     106     129 ..     106     133 .. 0.85
   2 !    8.2   0.1   0.00086       2.6      28      41 .]     160     173 ..     159     173 .. 0.89
   3 !   26.5   0.2   1.5e-09   4.5e-06       2      40 ..     176     216 ..     175     217 .. 0.96
   4 !   11.7   0.0     7e-05      0.21       4      40 ..     222     262 ..     219     263 .. 0.85
   5 !   15.1   0.0   6.1e-06     0.018       5      38 ..     270     302 ..     266     305 .. 0.89
   6 !    8.3   0.0   0.00083       2.5       8      38 ..     316     347 ..     310     349 .. 0.93
   7 !   23.3   0.0   1.6e-08   4.8e-05       5      41 .]     357     393 ..     353     393 .. 0.95
   8 !   21.2   0.1   7.1e-08   0.00021       3      41 .]     397     437 ..     395     437 .. 0.95
   9 ?   -0.4   0.0      0.43   1.3e+03       5      22 ..     487     504 ..     479     511 .. 0.65

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.057
                 SHHHHHHHHHTTHHHHHHHHTTTS CS
         Arm   1 nsenkdavieaGavppLvrLLsse 24 
                 +++ + +vi++G+   L +L++ +
  EFC39789.1 106 SNQLITQVIDSGIPTMLAKLIDEQ 129
                 5788999**********9999854 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00086
                 HHHHHHHHHHHHTT CS
         Arm  28 vqeeAawALsNLaa 41 
                 +q+eA+wAL+N ++
  EFC39789.1 160 LQFEAVWALTNVSS 173
                 69*********875 PP

  == domain 3  score: 26.5 bits;  conditional E-value: 1.5e-09
                 HHHHHHHHHTTHHHHHHHHTT..TSSHHHHHHHHHHHHHHT CS
         Arm   2 senkdavieaGavppLvrLLs..sedeevqeeAawALsNLa 40 
                 s ++++v+++G+++  ++L++      +++e++ wAL+N++
  EFC39789.1 176 SAHTQHVVSLGCIEKILKLIEcnGSCADLVEQCFWALGNIC 216
                 7789************************************9 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 7e-05
                 HHHHHHHTTHHHHHHHHTT....TSSHHHHHHHHHHHHHHT CS
         Arm   4 nkdavieaGavppLvrLLs....sedeevqeeAawALsNLa 40 
                  +d+v ++Ga+ + + + +    +   + +++A+wAL+N+ 
  EFC39789.1 222 YRDLVLSHGALSIMLPFFKtnptTYRLSFLRNATWALANMM 262
                 68888999999999999998888899999**********86 PP

  == domain 5  score: 15.1 bits;  conditional E-value: 6.1e-06
                 HHHHHHTTHHHHHHHHTT.TSSHHHHHHHHHHHHH CS
         Arm   5 kdavieaGavppLvrLLs.sedeevqeeAawALsN 38 
                 +++v +a   p+ ++L++  +deev+ + +wALs+
  EFC39789.1 270 IEYVKDA--FPIMIDLIQnQTDEEVLIDTCWALSH 302
                 6777777..9***********************97 PP

  == domain 6  score: 8.3 bits;  conditional E-value: 0.00083
                 HHHTTHHHHHHHHTT.TSSHHHHHHHHHHHHH CS
         Arm   8 vieaGavppLvrLLs.sedeevqeeAawALsN 38 
                  i+aG+ ++ v++L+   +  vq +A++ L+N
  EFC39789.1 316 FINAGVTKRVVSFLNhGSSYAVQSPALRILGN 347
                 599****************************9 PP

  == domain 7  score: 23.3 bits;  conditional E-value: 1.6e-08
                 HHHHHHTTHHHHHHHHTTTSSHHHHHHHHHHHHHHTT CS
         Arm   5 kdavieaGavppLvrLLssedeevqeeAawALsNLaa 41 
                 +d+v e+G +++L   L++ ++++++eA+w LsN++a
  EFC39789.1 357 TDHVLESGLLEVLPLILDHSKQGMKKEAVWILSNITA 393
                 799********************************96 PP

  == domain 8  score: 21.2 bits;  conditional E-value: 7.1e-08
                 HHHHHHHHTTHHHHHHHHTT..TSSHHHHHHHHHHHHHHTT CS
         Arm   3 enkdavieaGavppLvrLLs..sedeevqeeAawALsNLaa 41 
                 ++ +  i+aG v++ ++ L+     ++v++eA wA++N+++
  EFC39789.1 397 PQVQKAIDAGLVQQALDILNnnESPVSVKKEAFWAVRNICD 437
                 789999**********************************6 PP

  == domain 9  score: -0.4 bits;  conditional E-value: 0.43
                 HHHHHHTTHHHHHHHHTT CS
         Arm   5 kdavieaGavppLvrLLs 22 
                 ++ v ++G+++    ++s
  EFC39789.1 487 IQSVKDYGVIETIEGMMS 504
                 566777777776666666 PP

>> HEAT_EZ  HEAT-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       1.6   4.7e+03      26      44 ..     118     131 ..     110     134 .. 0.77
   2 !    5.3   0.0    0.0094        28       3      55 .]     160     215 ..     159     215 .. 0.59
   3 !   13.6   0.0   2.4e-05     0.072       5      53 ..     252     301 ..     247     302 .. 0.89
   4 ?    4.4   0.0     0.018        54       5      55 .]     339     391 ..     335     391 .. 0.66
   5 !    9.2   0.0   0.00057       1.7       5      55 .]     382     435 ..     378     435 .. 0.89

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.6
     HEAT_EZ  26 vpeilpaLlalLnddsdeV 44 
                 +p +l+ L+     d++eV
  EFC39789.1 118 IPTMLAKLI-----DEQEV 131
                 677888899.....99998 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.0094
     HEAT_EZ   3 vRraAawaLGrlaggepellqp.lvpeilpaLlalL.nd.dsdeVRaaAagaLgnl 55 
                 +++ A+waL ++ +g + + q  +    +   l+l  ++ ++++  +++ +aLgn+
  EFC39789.1 160 LQFEAVWALTNVSSGSSAHTQHvVSLGCIEKILKLIeCNgSCADLVEQCFWALGNI 215
                 68999****88776655554441333333333344433347777778888888876 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 2.4e-05
     HEAT_EZ   5 raAawaLGr.laggepellqplvpeilpaLlalLnddsd.eVRaaAagaLg 53 
                 r+A waL++ +  g p     +v+++ p ++ l ++  d eV   +++aL+
  EFC39789.1 252 RNATWALANmMR-GKPSVSIEYVKDAFPIMIDLIQNQTDeEVLIDTCWALS 301
                 89*******666.99999999*************665555**********8 PP

  == domain 4  score: 4.4 bits;  conditional E-value: 0.018
     HEAT_EZ   5 raAawaLGr.laggepel....lqplvpeilpaLlalLnddsdeV..RaaAagaLgnl 55 
                   A++ LG+ + +g++      l+  + e+lp+ l     d+++   ++ A++ L+n+
  EFC39789.1 339 SPALRILGNvIGSGNDTStdhvLESGLLEVLPLIL-----DHSKQgmKKEAVWILSNI 391
                 55777888876666666633335555556666666.....6666666*********97 PP

  == domain 5  score: 9.2 bits;  conditional E-value: 0.00057
     HEAT_EZ   5 raAawaLGr.....laggepellqplvpeilpaLlalLnddsd.eVRaaAagaLgnl 55 
                   A+w L++     ++++ +  +++lv+++l+ L    n++s+ +V++ A +a +n+
  EFC39789.1 382 KEAVWILSNitagtVPQVQKAIDAGLVQQALDILN---NNESPvSVKKEAFWAVRNI 435
                 689****888888899999999999*********9...88888999*******9987 PP

>> RICTOR_V  Rapamycin-insensitive companion of mTOR, domain 5
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.1   0.1     0.037   1.1e+02       6      37 ..     164     196 ..     163     202 .. 0.84
   2 !    7.4   0.0    0.0018       5.3       5      40 ..     207     243 ..     203     246 .. 0.81
   3 ?    1.4   0.0      0.13   3.8e+02       3      38 ..     251     286 ..     250     292 .. 0.81
   4 ?   -2.3   0.0       1.8   5.5e+03      22      53 ..     315     346 ..     298     350 .. 0.72
   5 ?    1.3   0.1      0.14   4.1e+02       4      39 ..     382     418 ..     380     436 .. 0.55
   6 ?    1.1   0.0      0.16   4.9e+02       3      17 ..     425     439 ..     423     463 .. 0.76
   7 ?   -2.4   0.0       1.9   5.7e+03      20      39 ..     487     506 ..     481     510 .. 0.73

  Alignments for each domain:
  == domain 1  score: 3.1 bits;  conditional E-value: 0.037
    RICTOR_V   6 aLWaiGhigsselGie.lldeydivedivelae 37 
                 a Wa+ ++ s  +  +  + +  ++e+i++l+e
  EFC39789.1 164 AVWALTNVSSGSSAHTqHVVSLGCIEKILKLIE 196
                 79********777766688888*******9987 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0018
    RICTOR_V   5 aaLWaiGhigsselGie.lldeydivedivelaeesp 40 
                 ++ Wa+G+i+    G++ l+ ++ +++ ++  +++ p
  EFC39789.1 207 QCFWALGNICGDSVGYRdLVLSHGALSIMLPFFKTNP 243
                 899*******999999988888888887777776665 PP

  == domain 3  score: 1.4 bits;  conditional E-value: 0.13
    RICTOR_V   3 lKaaLWaiGhigsselGielldeydivedivelaee 38 
                 l+ a Wa++++   +  +++ +  d+++ +++l+++
  EFC39789.1 251 LRNATWALANMMRGKPSVSIEYVKDAFPIMIDLIQN 286
                 78999******9999888877777788887777776 PP

  == domain 4  score: -2.3 bits;  conditional E-value: 1.8
    RICTOR_V  22 lldeydivedivelaeespvlslRGtafyvLg 53 
                 l+ +  + +++v+  ++ +++ +   a+ +Lg
  EFC39789.1 315 LFINAGVTKRVVSFLNHGSSYAVQSPALRILG 346
                 44455888888888888888888887777776 PP

  == domain 5  score: 1.3 bits;  conditional E-value: 0.14
    RICTOR_V   4 KaaLWaiGhigs.selGie.lldeydivedivelaees 39 
                 K a W++ +i + +   ++  +d   +v++ +++ ++ 
  EFC39789.1 382 KEAVWILSNITAgTVPQVQkAIDA-GLVQQALDILNNN 418
                 788888888866334444435554.6666555555544 PP

  == domain 6  score: 1.1 bits;  conditional E-value: 0.16
    RICTOR_V   3 lKaaLWaiGhigsse 17 
                 +K a Wa+ +i+  +
  EFC39789.1 425 KKEAFWAVRNICDLP 439
                 599********9854 PP

  == domain 7  score: -2.4 bits;  conditional E-value: 1.9
    RICTOR_V  20 ielldeydivedivelaees 39 
                 i+ +++y ++e+i  ++ ++
  EFC39789.1 487 IQSVKDYGVIETIEGMMSST 506
                 67778888888887777665 PP

>> Atx10homo_assoc  Spinocerebellar ataxia type 10 protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.2   0.0     0.007        21       5      61 ..     164     220 ..     160     242 .. 0.88
   2 ?   -2.5   0.0       1.8   5.4e+03       6      35 ..     342     375 ..     338     378 .. 0.64
   3 !    9.4   0.0   0.00035         1       1      70 [.     380     447 ..     380     461 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.007
  Atx10homo_assoc   5 lvrllgnlvyknkevqdkvreldgleliLsqcniDdnnPfirewailairnLlegne 61 
                       v  l+n++  +++  + v++l+ +e iL+ ++ + +   + e++ +a+ n++ ++ 
       EFC39789.1 164 AVWALTNVSSGSSAHTQHVVSLGCIEKILKLIECNGSCADLVEQCFWALGNICGDSV 220
                      56678999999999999*********************99***********998875 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.8
  Atx10homo_assoc   6 vrllgnlv.yknkevqdkvreldg...leliLsq 35 
                      +r+lgn++   n +  d v e +    l+liL++
       EFC39789.1 342 LRILGNVIgSGNDTSTDHVLESGLlevLPLILDH 375
                      6788887524577778888886652225667765 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 0.00035
  Atx10homo_assoc   1 fKrelvrllgnlvyknkevqdkvreldgleliLsqcniDdnnPfirewailairnLlegneenqelvaeL 70 
                      +K+e v +l+n++       +k  + + ++  L+  n +++   +++ a +a+rn+++    n ++v+ L
       EFC39789.1 380 MKKEAVWILSNITAGTVPQVQKAIDAGLVQQALDILNNNESPVSVKKEAFWAVRNICD--LPNEKVVKYL 447
                      69999*******9998877777778999*********99999999************7..4566666665 PP

>> Phage_NinH  Phage NinH protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.82   2.5e+03       8      35 ..     118     144 ..     114     151 .. 0.75
   2 ?    9.7   0.0   0.00026      0.77       5      28 ..     496     519 ..     494     524 .. 0.90

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.82
  Phage_NinH   8 iPdlLvetyGnqtEvARrlkcsRatvRk 35 
                 iP +L +    q EvA+  + s +  R 
  EFC39789.1 118 IPTMLAKLIDEQ-EVAKYFNISEGSTRT 144
                 899998887776.899988877776665 PP

  == domain 2  score: 9.7 bits;  conditional E-value: 0.00026
  Phage_NinH   5 vktiPdlLvetyGnqtEvARrlkc 28 
                 + ti  ++  t  n tE AR++ +
  EFC39789.1 496 IETIEGMMSSTSSNETELARKILS 519
                 689******************965 PP

>> DUF4868  Domain of unknown function (DUF4868)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       2.6   7.7e+03      16      36 ..      35      55 ..      32      64 .. 0.80
   2 ?   -2.1   0.2         1   3.1e+03     107     158 ..     122     138 ..      86     165 .. 0.46
   3 ?   11.4   0.2   7.5e-05      0.22      92     136 ..     484     528 ..     472     529 .] 0.87

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 2.6
     DUF4868 16 kklflykkiypitrlkkskkl 36
                k+++l k++  +++l+ks+ +
  EFC39789.1 35 KEVWLQKQKVRNNLLNKSRAR 55
                789999999999999999865 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 1
     DUF4868 107 veklkeyveindlkklrklakikkkgvllykqedlieklkkvpklklnikfe 158
                 + kl++                                   + ++   ++++
  EFC39789.1 122 LAKLID-----------------------------------EQEVAKYFNIS 138
                 333322...................................22222222222 PP

  == domain 3  score: 11.4 bits;  conditional E-value: 7.5e-05
     DUF4868  92 qkviseieelglienveklkeyveindlkklrklakikkkgvlly 136
                 ++vi++++++g+ie +e + +  + n+++ +rk+++i ++++l++
  EFC39789.1 484 ETVIQSVKDYGVIETIEGMMSSTSSNETELARKILSIVNNRELEM 528
                 579****************99999999999**********99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (529 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       771  (0.043003); expected 358.6 (0.02)
Passed bias filter:                      581  (0.0324056); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.68u 0.34s 00:00:01.02 Elapsed: 00:00:00.53
# Mc/sec: 3013.11
//
Query:       EFC39790.1  [L=336]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.4e-19   70.9   0.6    6.1e-19   68.8   0.6    1.8  1  Nucleotid_trans  Nucleotide-diphospho-sugar transferase
     0.0077   15.8   0.6      0.011   15.3   0.6    1.3  1  Glyco_transf_8   Glycosyl transferase family 8
  ------ inclusion threshold ------
      0.057   13.3   0.2       0.76    9.7   0.2    2.4  1  DUF3695          Protein of unknown function (DUF3695)
      0.081   13.6   0.4         16    6.2   0.0    2.6  2  DUF5395          Family of unknown function (DUF5395)


Domain annotation for each model (and alignments):
>> Nucleotid_trans  Nucleotide-diphospho-sugar transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   68.8   0.6   1.4e-22   6.1e-19      39     212 .]     117     320 ..      91     320 .. 0.83

  Alignments for each domain:
  == domain 1  score: 68.8 bits;  conditional E-value: 1.4e-22
  Nucleotid_trans  39 kdeefksktykkmswrkvrlllellklGynvllsDvDvvWlrnpfpll....kyedaDvlvssDsldgttadelknli.NsGfffvrateatka 127
                       ++e  +k ++ ++ +k+ ++ + +k G+nvl+sD+Dvv ++np++++    ++ + D++++     + ++ ++++   N+G+++v++ +++++
       EFC39790.1 117 IQRELFTKHWEFVTLLKPIMVWKCVKKGFNVLFSDLDVVLFQNPTDFMrtypDTSKFDIIFQIETCGTYESLHRDDIKiNTGVYYVKSEPKSIQ 210
                      5566667889999***********************************7555449*******98777776666666657*************** PP

  Nucleotid_trans 128 llkkwaeelasesglw......................Dqdvfnlllregaake...sglkvrvLdtalfvngkgyfvqvrdeeevktkkkpva 196
                      +l++w++ +  +  ++                      Dq+++n l+ +  ++       ++++L+  +f+n++ y + v  e   + k+++v+
       EFC39790.1 211 FLETWMKPILIDILTMfipvdvslldgpnpngrteptnDQAILNALVTKLKKNGnmdFVNSIGYLPVQKFPNKCQYTAIVGPEIDETGKNEMVL 304
                      ********9999665689999****************************766547666679***************9994444444446799** PP

  Nucleotid_trans 197 vhanycsgkedKlkrl 212
                       h+n+    ++Kl++l
       EFC39790.1 305 FHINGVWMSRQKLNYL 320
                      **99998888888876 PP

>> Glyco_transf_8  Glycosyl transferase family 8
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.6   2.5e-06     0.011      49     129 ..      90     171 ..      41     200 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 2.5e-06
  Glyco_transf_8  49 klnklassykevlellesdkksledf..esklklrspkylsllnylR.lylpelfpkldkilylDaDvvvqgdlseLwdldlk.g 129
                     +l++l +++ ++++      ++++++  +  + +  +k++   ++l+ +++++ ++k   +l+ D Dvv +++ +++++++ +  
      EFC39790.1  90 RLDQLDKDVEKFYK---NFMEQFKEKgeNVIQRELFTKHWEFVTLLKpIMVWKCVKKGFNVLFSDLDVVLFQNPTDFMRTYPDtS 171
                     34444444433321...112222222446789***************7889*************************999998844 PP

>> DUF3695  Protein of unknown function (DUF3695)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.2   0.00017      0.76      42      74 ..      92     124 ..      73     212 .. 0.90

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00017
     DUF3695  42 DsLDfrLksrYdhhrelfkekvevllqreTiqa 74 
                 D+LD  ++  Y++  e fkek e ++qre +++
  EFC39790.1  92 DQLDKDVEKFYKNFMEQFKEKGENVIQRELFTK 124
                 99***************************8776 PP

>> DUF5395  Family of unknown function (DUF5395)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.0    0.0035        16      26      54 ..      34      61 ..      12      72 .. 0.86
   2 ?    4.8   0.1      0.01        46      24      50 ..      88     115 ..      81     122 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0035
     DUF5395 26 tleeLDenlakelkkrgdfkgksqvevfm 54
                +l+eLD  + k+lkkr  +++ + + v m
  EFC39790.1 34 DLDELDGSIMKNLKKR-IYSSLTDIPVEM 61
                79*************9.888877787777 PP

  == domain 2  score: 4.8 bits;  conditional E-value: 0.01
     DUF5395  24 gktleeLDenlakelkkr.gdfkgksqv 50 
                  + l++LD++++k  k+  ++fk k++ 
  EFC39790.1  88 ETRLDQLDKDVEKFYKNFmEQFKEKGEN 115
                 5689************987899988654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (336 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1017  (0.0567237); expected 358.6 (0.02)
Passed bias filter:                      703  (0.0392102); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.61u 0.31s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2062.00
//
Query:       EFC39791.1  [L=932]
Description: BTB domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.6e-41  138.4   1.7    5.2e-08   33.0   0.1    6.7  6  Kelch_3   Galactose oxidase, central domain
    8.2e-36  121.4  12.3    2.9e-08   33.5   0.4    7.1  7  Kelch_5   Kelch motif
    7.6e-34  115.0   6.4    8.1e-09   34.9   0.3    6.3  6  Kelch_1   Kelch motif
    1.1e-33  115.0   5.7    2.8e-08   33.6   0.3    6.5  6  Kelch_4   Galactose oxidase, central domain
    1.5e-31  107.6   9.9    5.5e-08   32.8   0.2    6.3  6  Kelch_6   Kelch motif
    1.4e-30  105.8   0.6    1.2e-19   70.5   0.2    3.9  3  BTB       BTB/POZ domain
    2.3e-24   84.4   3.6    5.8e-05   22.9   0.1    6.8  6  Kelch_2   Kelch motif
    0.00026   21.0   0.3        1.8    8.7   0.0    3.3  3  BTB_3     BTB/POZ domain
    0.00068   18.7   0.1     0.0038   16.3   0.0    2.2  2  RAG2      Recombination activating protein 2
      0.001   19.1   0.3      0.071   13.2   0.1    2.8  2  BACK      BTB And C-terminal Kelch


Domain annotation for each model (and alignments):
>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.1   0.0   2.8e-06    0.0051       2      30 ..      33      62 ..      32      77 .. 0.93
   2 !   29.6   0.0   3.3e-10   5.9e-07       2      49 .]     119     173 ..     118     173 .. 0.91
   3 !   33.0   0.1   2.9e-11   5.2e-08       3      47 ..     177     222 ..     175     223 .. 0.91
   4 !   31.4   0.0   8.9e-11   1.6e-07       1      47 [.     225     273 ..     225     275 .. 0.84
   5 !   14.6   0.0   1.7e-05     0.031       2      46 ..     277     327 ..     276     327 .. 0.81
   6 ?    5.4   0.0     0.013        24       3      26 ..     333     359 ..     331     380 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.1 bits;  conditional E-value: 2.8e-06
     Kelch_3  2 drlyifGGlgd.dgqdrlndvyvydldtnt 30
                 ++yi+GG++   gq ++n++ vy+l++++
  EFC39791.1 33 QYMYIYGGADKaEGQHFSNSFVVYNLESGE 62
                59************************9986 PP

  == domain 2  score: 29.6 bits;  conditional E-value: 3.3e-10
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWaei........aslppaRaghaatai 49 
                 ++lyi+GG     ++++n++y++d+++ +W ++         +  pa +gh++ +i
  EFC39791.1 119 CTLYIYGGQL-EKGTASNSLYRFDIESMEWLKVkcsarhsaQDILPALYGHTTNVI 173
                 68********.78******************8878988887889********9886 PP

  == domain 3  score: 33.0 bits;  conditional E-value: 2.9e-11
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydldtntWa..ei.aslppaRaghaat 47 
                 ++yifGG +  g+++ nd+ v+d+++ntW   ++ +  p++R+gh+++
  EFC39791.1 177 KMYIFGGTD--GTNYFNDLMVIDTESNTWVreKTqGVKPSPRYGHTCV 222
                 7********..*******************85558889********85 PP

  == domain 4  score: 31.4 bits;  conditional E-value: 8.9e-11
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaei...aslpp.aRaghaat 47 
                 +++lyifGG +   q   nd+y++dldt tW+ i   +++ +  R++h+a 
  EFC39791.1 225 NNSLYIFGGGN--DQHLFNDLYSLDLDTLTWKHIkieGTTDSaKRVHHTAN 273
                 699********..58999**************555486665569****986 PP

  == domain 5  score: 14.6 bits;  conditional E-value: 1.7e-05
     Kelch_3   2 drlyifGGlgddgqdrlndvyvydldtntWa..ei.....aslppaRaghaa 46 
                 +++ +fGGl  +   ++nd+ v+dl+   W+  +      ++ pp  +gh+a
  EFC39791.1 277 NKMIVFGGLV-NAHSHSNDLMVLDLEHFRWDieKPyvdknSPAPPSLVGHSA 327
                 89********.889999********877777652245555888999*99996 PP

  == domain 6  score: 5.4 bits;  conditional E-value: 0.013
     Kelch_3   3 rlyifGGlgd...dgqdrlndvyvydl 26 
                 +l+i+GG+ +   ++++ +n+vy + +
  EFC39791.1 333 KLWIIGGKFAendSSTQISNNVYTLET 359
                 69*******9887779999****9876 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.2   0.4   5.5e-08   9.9e-05       4      41 ..      21      60 ..      20      61 .. 0.93
   2 !    9.0   0.0   0.00077       1.4      16      41 ..     120     144 ..     106     145 .. 0.79
   3 !   18.4   0.1   8.6e-07    0.0015       3      42 .]     163     201 ..     163     201 .. 0.87
   4 !   33.5   0.4   1.6e-11   2.9e-08       2      41 ..     213     250 ..     213     251 .. 0.97
   5 !   16.4   0.0   3.6e-06    0.0065       5      42 .]     267     303 ..     265     303 .. 0.88
   6 !   23.6   0.0   2.1e-08   3.8e-05       2      37 ..     319     357 ..     318     359 .. 0.94
   7 ?   -1.8   0.0       1.9   3.3e+03      18      27 ..     687     697 ..     687     712 .. 0.72

  Alignments for each domain:
  == domain 1  score: 22.2 bits;  conditional E-value: 5.5e-08
     Kelch_5  4 pRaghcavtvs.ekiYvyGGkvg.rdgsvsddvyvLdlps 41
                +R+ h++v+ + +++Y+yGG +  +++++s+ + v++l+s
  EFC39791.1 21 QRYFHSSVIINkQYMYIYGGADKaEGQHFSNSFVVYNLES 60
                7*******9977**********8899************98 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00077
     Kelch_5  16 kiYvyGGkvgrdgsvsddvyvLdlps 41 
                  +Y+yGG   + g +s+ +y++d++s
  EFC39791.1 120 TLYIYGGQL-EKGTASNSLYRFDIES 144
                 49*******.89999********987 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 8.6e-07
     Kelch_5   3 ppRaghca.vtvsekiYvyGGkvgrdgsvsddvyvLdlpsf 42 
                 p+++gh + v++++k+Y++GG +g   ++++d+ v d++s+
  EFC39791.1 163 PALYGHTTnVIDGTKMYIFGGTDG--TNYFNDLMVIDTESN 201
                 689*****55678**********6..*******99888876 PP

  == domain 4  score: 33.5 bits;  conditional E-value: 1.6e-11
     Kelch_5   2 PppRaghcavtvsekiYvyGGkvgrdgsvsddvyvLdlps 41 
                 P+pR+gh  v +++++Y++GG +  d+++++d+y Ldl +
  EFC39791.1 213 PSPRYGHTCVHYNNSLYIFGGGN--DQHLFNDLYSLDLDT 250
                 99*********************..9***********986 PP

  == domain 5  score: 16.4 bits;  conditional E-value: 3.6e-06
     Kelch_5   5 RaghcavtvsekiYvyGGkvgrdgsv.sddvyvLdlpsf 42 
                 R +h a +  +k++v+GG v  + ++ s+d+ vLdl+ f
  EFC39791.1 267 RVHHTANIIANKMIVFGGLV--NAHShSNDLMVLDLEHF 303
                 899*****************..55555*********876 PP

  == domain 6  score: 23.6 bits;  conditional E-value: 2.1e-08
     Kelch_5   2 PppRaghcavtvsekiYvyGGkvg...rdgsvsddvyvL 37 
                 Pp++ gh+a ++++k++++GGk +   ++ ++s++vy+L
  EFC39791.1 319 PPSLVGHSAQMAGTKLWIIGGKFAendSSTQISNNVYTL 357
                 9***********************99999999*****98 PP

  == domain 7  score: -1.8 bits;  conditional E-value: 1.9
     Kelch_5  18 YvyGGkvg.rd 27 
                 Y+y+G v+ + 
  EFC39791.1 687 YLYSGNVSiNF 697
                 99***997433 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.5   0.1    0.0002      0.35       7      43 ..      28      67 ..      21      69 .. 0.83
   2 !   14.4   0.0   1.2e-05     0.021      13      41 ..     120     149 ..     115     152 .. 0.89
   3 !   34.9   0.3   4.5e-12   8.1e-09       7      41 ..     171     205 ..     166     208 .. 0.91
   4 !   31.8   0.0   4.2e-11   7.5e-08       1      40 [.     215     254 ..     215     257 .. 0.96
   5 !   18.0   0.0   8.7e-07    0.0016       2      39 ..     267     305 ..     266     310 .. 0.94
   6 ?    2.6   0.0     0.057     1e+02       3      23 ..     323     348 ..     321     356 .. 0.74

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.0002
                EEEETTEEEEEEEBCS...SSBEEEEEEEETTTTEEEEEC CS
     Kelch_1  7 avvvggkiYviGGsdg...gnalssvevyDpetntWrelp 43
                +     ++Y+ GG d    + +++s+ vy++e+++ ++l+
  EFC39791.1 28 VIINKQYMYIYGGADKaegQHFSNSFVVYNLESGEYHCLN 67
                4444579***************************998876 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 1.2e-05
                 EEEEEEEBCS.SSBEEEEEEEETTTTEEEE CS
     Kelch_1  13 kiYviGGsdg.gnalssvevyDpetntWre 41 
                  +Y+ GG+ + g+a++s++++D e+ +W +
  EFC39791.1 120 TLYIYGGQLEkGTASNSLYRFDIESMEWLK 149
                 69**********************999965 PP

  == domain 3  score: 34.9 bits;  conditional E-value: 4.5e-12
                 EEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEEE CS
     Kelch_1   7 avvvggkiYviGGsdggnalssvevyDpetntWre 41 
                  v  g+k+Y++GG dg n+ ++++v+D+e+ntW +
  EFC39791.1 171 NVIDGTKMYIFGGTDGTNYFNDLMVIDTESNTWVR 205
                 58899****************************87 PP

  == domain 4  score: 31.8 bits;  conditional E-value: 4.2e-11
                 BBBSEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEE CS
     Kelch_1   1 aragagavvvggkiYviGGsdggnalssvevyDpetntWr 40 
                 +r+g+++v  ++ +Y++GG++++   ++++ +D+ t tW 
  EFC39791.1 215 PRYGHTCVHYNNSLYIFGGGNDQHLFNDLYSLDLDTLTWK 254
                 7**************************************7 PP

  == domain 5  score: 18.0 bits;  conditional E-value: 8.7e-07
                 BBSEEEEEETTEEEEEEEBCS.SSBEEEEEEEETTTTEE CS
     Kelch_1   2 ragagavvvggkiYviGGsdg.gnalssvevyDpetntW 39 
                 r +++a  + +k+ v+GG  + ++ +++++v+D+e   W
  EFC39791.1 267 RVHHTANIIANKMIVFGGLVNaHSHSNDLMVLDLEHFRW 305
                 99********************************98888 PP

  == domain 6  score: 2.6 bits;  conditional E-value: 0.057
                 BSEEEEEETTEEEEEEEBCS.....S CS
     Kelch_1   3 agagavvvggkiYviGGsdg.....g 23 
                  g++a   g+k+ +iGG +       
  EFC39791.1 323 VGHSAQMAGTKLWIIGGKFAendssT 348
                 578888889********998544444 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   0.0   0.00011      0.19       2      40 ..      22      62 ..      21      68 .. 0.84
   2 !   28.2   0.0   7.8e-10   1.4e-06       5      41 ..     111     147 ..     109     158 .. 0.92
   3 !   25.6   0.4   5.1e-09   9.2e-06       4      42 ..     167     204 ..     166     214 .. 0.89
   4 !   33.6   0.3   1.5e-11   2.8e-08       1      42 [.     215     254 ..     215     263 .. 0.94
   5 !   10.1   0.0   0.00034      0.62       2      38 ..     267     302 ..     266     320 .. 0.85
   6 ?    1.5   0.0      0.17     3e+02       4      32 ..     324     355 ..     323     359 .. 0.75

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00011
     Kelch_4  2 RaghsatsipdgtiylfGGrgedg..tllndlylldlstnt 40
                R +hs++ i++ + y++GG+       ++n   +++l++++
  EFC39791.1 22 RYFHSSVIINKQYMYIYGGADKAEgqHFSNSFVVYNLESGE 62
                89******************997455666666669999886 PP

  == domain 2  score: 28.2 bits;  conditional E-value: 7.8e-10
     Kelch_4   5 hsatsipdgtiylfGGrgedgtllndlylldlstntW 41 
                 h++t++ + t+y++GG+ e+gt++n ly++d+++ +W
  EFC39791.1 111 HTMTQVSKCTLYIYGGQLEKGTASNSLYRFDIESMEW 147
                 ******999*************************999 PP

  == domain 3  score: 25.6 bits;  conditional E-value: 5.1e-09
     Kelch_4   4 ghsatsipdgtiylfGGrgedgtllndlylldlstntWr 42 
                 gh++ +i++ + y+fGG  +    +ndl ++d+++ntW 
  EFC39791.1 167 GHTTNVIDGTKMYIFGGTDGT-NYFNDLMVIDTESNTWV 204
                 8*******9***********8.7***************3 PP

  == domain 4  score: 33.6 bits;  conditional E-value: 1.5e-11
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtllndlylldlstntWr 42 
                 pR gh+++   ++++y+fGG +++  l+ndly ldl t tW+
  EFC39791.1 215 PRYGHTCVHY-NNSLYIFGGGNDQ-HLFNDLYSLDLDTLTWK 254
                 8*********.7***********9.9***************7 PP

  == domain 5  score: 10.1 bits;  conditional E-value: 0.00034
     Kelch_4   2 RaghsatsipdgtiylfGGrgedgtllndlylldlst 38 
                 R++h+a  i  ++ ++fGG  +  + +ndl +ldl+ 
  EFC39791.1 267 RVHHTANIIA-NKMIVFGGLVNAHSHSNDLMVLDLEH 302
                 99*******6.78888******889999999999975 PP

  == domain 6  score: 1.5 bits;  conditional E-value: 0.17
     Kelch_4   4 ghsatsipdgtiylfGGrgedg....tllndly 32 
                 ghsa   +  +++++GG  +++    +++n++y
  EFC39791.1 324 GHSAQMAG-TKLWIIGGKFAENdsstQISNNVY 355
                 67777774.89******9988767777777666 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.7   0.2   6.6e-05      0.12       2      38 ..      22      61 ..      22      64 .. 0.89
   2 !   19.3   0.0   5.7e-07     0.001       4      42 ..     110     149 ..     108     152 .. 0.88
   3 !   25.7   0.1   5.5e-09   9.9e-06       4      41 ..     167     204 ..     164     206 .. 0.89
   4 !   32.8   0.2     3e-11   5.5e-08       1      43 [.     215     256 ..     215     257 .. 0.94
   5 !   16.7   0.0   3.8e-06    0.0067       2      41 ..     267     306 ..     266     307 .. 0.94
   6 ?    0.2   0.0      0.59   1.1e+03       4      21 ..     324     341 ..     320     355 .. 0.79

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 6.6e-05
     Kelch_6  2 raghslvsvgg.kiYifGGytds..spylnkvwvydpetk 38
                r++hs+v+++  + Yi+GG++ +    ++n++ vy++e++
  EFC39791.1 22 RYFHSSVIINKqYMYIYGGADKAegQHFSNSFVVYNLESG 61
                78********87*********9999667899999999987 PP

  == domain 2  score: 19.3 bits;  conditional E-value: 5.7e-07
     Kelch_6   4 ghslvsvgg.kiYifGGytdsspylnkvwvydpetksWeq 42 
                 +h+++ v   ++Yi+GG+   ++++n+++++d+e++ W +
  EFC39791.1 110 QHTMTQVSKcTLYIYGGQLEKGTASNSLYRFDIESMEWLK 149
                 57777777778*******999*****************65 PP

  == domain 3  score: 25.7 bits;  conditional E-value: 5.5e-09
     Kelch_6   4 ghslvsvgg.kiYifGGytdsspylnkvwvydpetksWe 41 
                 gh++ +++g k YifGG ++ ++y+n+++v+d e+++W 
  EFC39791.1 167 GHTTNVIDGtKMYIFGGTDG-TNYFNDLMVIDTESNTWV 204
                 79996666659*********.9****************6 PP

  == domain 4  score: 32.8 bits;  conditional E-value: 3e-11
     Kelch_6   1 praghslvsvggkiYifGGytdsspylnkvwvydpetksWeql 43 
                 pr+gh++v +++++YifGG +d+   +n+++ +d++t +W+++
  EFC39791.1 215 PRYGHTCVHYNNSLYIFGGGNDQ-HLFNDLYSLDLDTLTWKHI 256
                 799*******************7.578*************996 PP

  == domain 5  score: 16.7 bits;  conditional E-value: 3.8e-06
     Kelch_6   2 raghslvsvggkiYifGGytdsspylnkvwvydpetksWe 41 
                 r++h++ ++ +k  +fGG++++++++n+++v+d+e  +W+
  EFC39791.1 267 RVHHTANIIANKMIVFGGLVNAHSHSNDLMVLDLEHFRWD 306
                 789999****************************999996 PP

  == domain 6  score: 0.2 bits;  conditional E-value: 0.59
     Kelch_6   4 ghslvsvggkiYifGGyt 21 
                 ghs+  +g k++i+GG  
  EFC39791.1 324 GHSAQMAGTKLWIIGGKF 341
                 566666888*******75 PP

>> BTB  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.5   0.0   2.7e-08   4.8e-05       2     108 ..     379     516 ..     378     518 .. 0.83
   2 !   70.5   0.2   6.9e-23   1.2e-19       8     109 ..     619     725 ..     614     727 .. 0.89
   3 !    7.9   0.0     0.002       3.6      78     110 ..     727     758 ..     723     759 .. 0.88

  Alignments for each domain:
  == domain 1  score: 23.5 bits;  conditional E-value: 2.7e-08
                 HHHHHHTTTS-EEEEETTTEEEEE-HHHHHHH-HHHHHHHTST.....................TTTTCCCE.......EEEETTSGHHHHHHHHHHHH CS
         BTB   2 nelresgelcDvtlvvgdgkefkahkavLaarSpyFkalftsk.....................eieessvs.......eielddvepeafealLefiY 72 
                  +l +s++++D +l  + g+ ++ah+ +  ar+p +++                          +              + + ++v++  f+ lLe++Y
  EFC39791.1 379 SSLIDSEDYSDTILEYN-GQFYHAHRPIIYARAPLLYRECMRLssndivnvgdaadalmkkkkhK------AtekyeelKQKSEKVKSYGFRGLLEYLY 470
                 5678999**********.9****************985332222358*********997544331......235666666667999999********** PP

                 HSEEEC-..........CGGGHHHHHHHHHHHT-HHHHHHHHHHHH CS
         BTB  73 tgeleit..........seenleelLaaadllqiprlkkaceeflk 108
                 t+++ +            +  + el+ +a  + ++rl ++c+++l+
  EFC39791.1 471 TDRVGLLdgedipvdvdIRCCIYELIFLAVAFSLDRLFALCSKHLD 516
                 ****9999999999999679999******************99987 PP

  == domain 2  score: 70.5 bits;  conditional E-value: 6.9e-23
                 TTTS-EEEEETT.TEEEEE-HHHHHHH-HHHHHHHTST.....TTTTCCCE......EEEETTSGHHHHHHHHHHHHHSEEEC-CGGGHHHHHHHHHHH CS
         BTB   8 gelcDvtlvvgd.gkefkahkavLaarSpyFkalftsk.....eieessvs......eielddvepeafealLefiYtgeleitseenleelLaaadll 94 
                 ++ cDv + vg  ++++ +h+++L +rS++F++++++k     +             e el+ + p++f+ +L+++Y+g+++i+  +  +elL aa+ +
  EFC39791.1 619 QSNCDVLFSVGAeKERIACHRCILNSRSKFFRRMLSNKpqqqhS------IgmtkidEFELTGIRPQVFKLVLQYLYSGNVSIN-FDISVELLVAAEVY 710
                 478********999************************444332......3466666**************************7.9************* PP

                 T-HHHHHHHHHHHHH CS
         BTB  95 qiprlkkaceeflkq 109
                 q++rl  +c++ +++
  EFC39791.1 711 QLERLSLMCQSVIEK 725
                 *********999876 PP

  == domain 3  score: 7.9 bits;  conditional E-value: 0.002
                 C-CGGGHHHHHHHHHHHT-HHHHHHHHHHHHHH CS
         BTB  78 itseenleelLaaadllqiprlkkaceeflkqs 110
                 i+  +n+  ++++ad +++++l + c++f+ ++
  EFC39791.1 727 IH-PGNASTIFSIADSYDVKHLRETCTYFIVHN 758
                 54.789999********************9875 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.2   0.0   0.00016      0.29       5      46 ..      25      67 ..      21      69 .. 0.83
   2 !   10.2   0.0   0.00033      0.59      14      47 ..     121     152 ..     109     154 .. 0.91
   3 !   17.1   0.0   2.2e-06     0.004       2      44 ..     165     205 ..     164     210 .. 0.90
   4 !   22.9   0.1   3.3e-08   5.8e-05       1      43 [.     215     254 ..     215     258 .. 0.97
   5 !   11.0   0.0   0.00019      0.34       2      43 ..     267     306 ..     266     310 .. 0.83
   6 !    6.4   0.0    0.0051       9.1       2      39 ..     322     359 ..     321     360 .. 0.92

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00016
     Kelch_2  5 hsssvp.ggkiyvvGGahtdnpnlsssdvhvldlekhvWeevt 46
                hss+ +  + +y++GGa+  ++ ++s+++ v++le+ +  +++
  EFC39791.1 25 HSSVIInKQYMYIYGGADKAEGQHFSNSFVVYNLESGEYHCLN 67
                5666444899*************************98888877 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00033
     Kelch_2  14 iyvvGGahtdnpnlsssdvhvldlekhvWeevtp 47 
                 +y++GG    +++ +s++++ +d e+ +W +v++
  EFC39791.1 121 LYIYGGQ--LEKGTASNSLYRFDIESMEWLKVKC 152
                 8******..********************99988 PP

  == domain 3  score: 17.1 bits;  conditional E-value: 2.2e-06
     Kelch_2   2 rgghsssvp.ggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44 
                 ++gh++ v+ g k+y++GG    ++  +++d++v d+e+++W +
  EFC39791.1 165 LYGHTTNVIdGTKMYIFGGT---DGTNYFNDLMVIDTESNTWVR 205
                 789999999788********...*******************87 PP

  == domain 4  score: 22.9 bits;  conditional E-value: 3.3e-08
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWe 43 
                 +r+gh+++  ++ +y++GG    n+ + ++d++ ldl++ +W+
  EFC39791.1 215 PRYGHTCVHYNNSLYIFGGG---NDQHLFNDLYSLDLDTLTWK 254
                 7*******************...*******************7 PP

  == domain 5  score: 11.0 bits;  conditional E-value: 0.00019
     Kelch_2   2 rgghsssvpggkiyvvGGahtdnpnls.ssdvhvldlekhvWe 43 
                 r++h++  + +k++v+GG     + +s s+d++vldle+ +W+
  EFC39791.1 267 RVHHTANIIANKMIVFGGL---VNAHShSNDLMVLDLEHFRWD 306
                 89999999***********...666662579999999999998 PP

  == domain 6  score: 6.4 bits;  conditional E-value: 0.0051
     Kelch_2   2 rgghsssvpggkiyvvGGahtdnpnlsssdvhvldlek 39 
                 ++ghs+ + g k+ ++GG ++ n+++ +++++v+ le+
  EFC39791.1 322 LVGHSAQMAGTKLWIIGGKFAENDSSTQISNNVYTLET 359
                 79*****************************9997776 PP

>> BTB_3  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.2   2.1e+03      48      69 ..     452     473 ..     430     498 .. 0.69
   2 !    8.7   0.0   0.00099       1.8      11      84 ..     635     707 ..     626     725 .. 0.72
   3 !    8.2   0.0    0.0014       2.5      72     101 ..     738     767 ..     730     772 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.2
       BTB_3  48 evaegisaevfraildyykkGv 69 
                 + +e++ +  fr +l+y  +  
  EFC39791.1 452 QKSEKVKSYGFRGLLEYLYTDR 473
                 4567899999******976544 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00099
       BTB_3  11 fvvdkelfrahPdtllgrmfgsslesnltk.pnekGeyevaegisaevfraildyykkGvikcPpgvsvkelrea 84 
                   +++ +++++   ++ rm++++ +++    + +  e+e+ +gi  +vf+ +l+y  +G ++    +sv+ l  a
  EFC39791.1 635 IACHRCILNSRS-KFFRRMLSNKPQQQHSIgMTKIDEFEL-TGIRPQVFKLVLQYLYSGNVSINFDISVELLVAA 707
                 555555555543.456788887765554441555556665.69*********************99999877665 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.0014
       BTB_3  72 cPpgvsvkelreacdyllipfnaetvkcen 101
                   ++  vk+lre+c y+++   ++  k++n
  EFC39791.1 738 IADSYDVKHLRETCTYFIVHNMSKVRKTNN 767
                 567889***********9976665555665 PP

>> RAG2  Recombination activating protein 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.1e-06    0.0038      18     108 ..      99     183 ..      86     202 .. 0.81
   2 ?   -1.2   0.0      0.45     8e+02      80      92 ..     209     221 ..     193     237 .. 0.74

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.1e-06
                 -----SS-EEEEE-S-S.SS--EEEEEEEEETTTEEEEEEEEEEEEEE-SS-EEEEEEEE--BSS---S-BS-EEEEEEETTEEEEEEE-- CS
        RAG2  18 ylpplrypaictlkasdesekeqylihGGktpnnelsdklyilslvskankkvtlrctekelvgdvpearyGhtlsvvysrGksavvlfGG 108
                  +p  + p +++ + ++  +k++  i+GG+      s++ly + ++s +     ++c+ ++ + d+  a yGht +v+     +++ +fGG
  EFC39791.1  99 LFPNAKLPKLSQHTMTQ-VSKCTLYIYGGQLEKGTASNSLYRFDIESMEWL--KVKCSARHSAQDILPALYGHTTNVIDG---TKMYIFGG 183
                 56677777777777766.66677779****************999998765..569*********************964...44566777 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.45
                 BSS---S-BS-EE CS
        RAG2  80 vgdvpearyGhtl 92 
                 +g  p++ryGht 
  EFC39791.1 209 QGVKPSPRYGHTC 221
                 5667899999985 PP

>> BACK  BTB And C-terminal Kelch
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.062   1.1e+02       4      28 ..     703     727 ..     700     729 .. 0.88
   2 !   13.2   0.1     4e-05     0.071       4      41 ..     735     773 ..     732     791 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.062
        BACK   4 ilefAeaysceeLaeaakefilknf 28 
                 +l  Ae y++e+L+ +++++i+k++
  EFC39791.1 703 LLVAAEVYQLERLSLMCQSVIEKKI 727
                 6778*****************9987 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 4e-05
        BACK   4 ilefAeaysceeLaeaakefilknfeevlkseeFle.Ls 41 
                 i+++A++y +++L+e+++ fi +n+++v k++++++ Ls
  EFC39791.1 735 IFSIADSYDVKHLRETCTYFIVHNMSKVRKTNNYKKdLS 773
                 899*****************************9987444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (932 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1212  (0.0676); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.82u 0.31s 00:00:01.12 Elapsed: 00:00:00.50
# Mc/sec: 5615.34
//
Query:       EFC39792.1  [L=906]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.2e-11   43.6   0.0    1.8e-10   40.6   0.0    2.2  2  Glycos_transf_1  Glycosyl transferases group 1
    3.6e-10   40.4   0.0    8.6e-10   39.2   0.0    1.6  1  Glyco_trans_1_4  Glycosyl transferases group 1
     0.0011   19.4   0.0     0.0024   18.2   0.0    1.6  1  Glyco_trans_1_2  Glycosyl transferases group 1
  ------ inclusion threshold ------
      0.015   15.3   0.0      0.031   14.3   0.0    1.5  1  Glyco_transf_4   Glycosyltransferase Family 4
       0.17   11.9   0.0        0.4   10.7   0.0    1.6  1  INCENP_ARK-bind  Inner centromere protein, ARK binding region


Domain annotation for each model (and alignments):
>> Glycos_transf_1  Glycosyl transferases group 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.15   5.3e+02       6      37 ..     666     697 ..     661     733 .. 0.79
   2 !   40.6   0.0   5.1e-14   1.8e-10      82     170 ..     761     859 ..     753     861 .. 0.91

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.15
                      HHHTTTTTT-EEEEEESS-TTTTTHHHHHHHH CS
  Glycos_transf_1   6 rkklgknekkkiilsvgrlekeKgvdllikaf 37 
                       k+l  + + + ++sv   e++Kg+++l+ a+
       EFC39792.1 666 VKQLDYRPNHYHFFSVFKYEERKGPEYLLNAY 697
                      5666666777889999999999*****99996 PP

  == domain 2  score: 40.6 bits;  conditional E-value: 5.1e-14
                      HSSSHHHHHHCESEEEEEESSBSS-HHHHHHHHTT--EEEETTTTHCHHCHTTT............SEEEE-TT-HHHHHHHHHHHHHSHHHHH CS
  Glycos_transf_1  82 sredleellknadifvlpsisEgfGivllEAmaaglpviasnaggpaevvkdge............tGllvkpnnaealaeairklledeelre 163
                      + + +++l++  d+fvl  + Eg G++  EAm+ glp+i + +gg +e  +d+             + ++++++   +l   +r++  ++++++
       EFC39792.1 761 PTTVMPQLYHLMDCFVLATRGEGYGLPFAEAMSMGLPTIGTRYGGQLEFMNDNNsylidiekrkpdQEFVIPKV--RHLRHLLRQVYANRKESK 852
                      5566899**********************************************************666666666..****************** PP

                      HHHHHHH CS
  Glycos_transf_1 164 rlgenar 170
                      ++g+nar
       EFC39792.1 853 KMGRNAR 859
                      ******8 PP

>> Glyco_trans_1_4  Glycosyl transferases group 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.2   0.0   2.4e-13   8.6e-10       6     119 ..     678     821 ..     674     837 .. 0.71

  Alignments for each domain:
  == domain 1  score: 39.2 bits;  conditional E-value: 2.4e-13
                      EES--.-GG.GTHHHHHHHH.HHHH.H.HEEEEEES......---..........HHHHHHHTT-.............T...TEEEE---...T CS
  Glyco_trans_1_4   6 fvGrl.eenvkgvdllleav.pllrkk.dvrlvivG......dgprp........eeleelaagl.............e..erveftGfv...e 64 
                      f++ + +e++kg ++ll+a   + +k  dv+l+i        +g r+        ++       +             +  + v ++ +v   +
       EFC39792.1 678 FFSVFkYEERKGPEYLLNAYfSEFAKVkDVTLHIQTyifmhpNG-RDeevvemeiDK-------VrqaflmkhpeltkDdlPFVNIMSHViptT 763
                      55666667889999999999999996645888888844433322.222233333322.......222223333333321225699999999744 PP

                      HHHHHHHH-SEEEE--..---SHHHHHHHHTT-EEEE-TGGGTTT--.TTSSEE--TT CS
  Glyco_trans_1_4  65 dlaellaaadvfvaPs..egfglkllEamaaglpvVatdvggiaevv.gengllvppg 119
                       +++l++ +d+fv+ +  eg gl   Eam++glp++ t+ gg  e++  +n +l++ +
       EFC39792.1 764 VMPQLYHLMDCFVLATrgEGYGLPFAEAMSMGLPTIGTRYGGQLEFMnDNNSYLIDIE 821
                      5***************999***********************9999977788998644 PP

>> Glyco_trans_1_2  Glycosyl transferases group 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.2   0.0   6.7e-07    0.0024       7      90 ..     780     875 ..     771     877 .. 0.89

  Alignments for each domain:
  == domain 1  score: 18.2 bits;  conditional E-value: 6.7e-07
  Glyco_trans_1_2   7 rsespnlrlfEaaacGafaltddaegleelftpgk.............evilfedleelaekiryllanpeerraiaeaarervlaehtydhra 87 
                      r e+  l + Ea+ +G + + ++  g+ e+ ++++             e+++   +  l   +r++ an++e ++++++ar +v+++ + +   
       EFC39792.1 780 RGEGYGLPFAEAMSMGLPTIGTRYGGQLEFMNDNNsylidiekrkpdqEFVI-PKVRHLRHLLRQVYANRKESKKMGRNARIWVENNISHNAVN 872
                      557788899*************99999999999999***********55555.899******************************99887776 PP

  Glyco_trans_1_2  88 eql 90 
                      +ql
       EFC39792.1 873 QQL 875
                      666 PP

>> Glyco_transf_4  Glycosyltransferase Family 4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   8.7e-06     0.031     131     169 ..     609     647 ..     572     648 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 8.7e-06
  Glyco_transf_4 131 lrradrviavSeatadelrerygvppekitVipnGvDle 169
                     l+ +d +  +S ++ d l+  ygv+p+ki V+p +vD+e
      EFC39792.1 609 LKYVDELWLPSSFLVDPLINTYGVDPDKIFVVPEPVDIE 647
                     7788889999***************************98 PP

>> INCENP_ARK-bind  Inner centromere protein, ARK binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0   0.00011       0.4      21      52 ..     616     647 ..     614     648 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00011
  INCENP_ARK-bind  21 WAqspeLrqaLikqepiDpdeiFGpikplnle 52 
                      W  s+ L   Li+ + +Dpd+iF  ++p+++e
       EFC39792.1 616 WLPSSFLVDPLINTYGVDPDKIFVVPEPVDIE 647
                      6668889999*************999999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (906 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1151  (0.0641977); expected 358.6 (0.02)
Passed bias filter:                      512  (0.0285571); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.83u 0.33s 00:00:01.15 Elapsed: 00:00:00.53
# Mc/sec: 5180.15
//
Query:       EFC39793.1  [L=438]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
      4e-08   33.0  12.3     0.0014   18.6   0.0    6.9  7  Arm         Armadillo/beta-catenin-like repeat
     0.0004   19.7   2.0      0.033   13.4   0.0    2.7  3  SIL1        Nucleotide exchange factor SIL1
     0.0035   17.2   2.1          8    6.3   0.0    3.4  3  CK2S        Casein Kinase 2 substrate
  ------ inclusion threshold ------
      0.021   14.8   7.4      0.039   13.9   0.6    2.7  2  DUF3361     Domain of unknown function (DUF3361)
      0.063   12.7   6.8      0.077   12.4   1.0    3.4  3  DUF5578     Family of unknown function (DUF5578)
       0.14   12.4   2.1        2.8    8.1   0.3    3.2  3  RTP1_C1     Required for nuclear transport of RNA pol II C-te
        0.6   10.5   2.1        2.1    8.8   0.1    2.8  3  REV1_C      DNA repair protein REV1 C-terminal domain
        0.6   10.1  11.8       0.26   11.3   3.5    3.1  3  SYCP2_ARLD  Synaptonemal complex 2 armadillo-repeat-like doma


Domain annotation for each model (and alignments):
>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.0   0.0   0.00031       0.7       5      29 ..      63      88 ..      60      89 .. 0.89
   2 !   18.6   0.0   6.1e-07    0.0014       1      40 [.      97     138 ..      97     139 .. 0.96
   3 ?    1.7   0.0      0.13     3e+02      12      39 ..     152     180 ..     151     182 .. 0.89
   4 ?   -0.2   0.9      0.53   1.2e+03      21      40 ..     202     221 ..     202     222 .. 0.86
   5 ?    1.4   0.0      0.16   3.6e+02       5      23 ..     229     247 ..     225     252 .. 0.81
   6 ?    0.9   0.0      0.23   5.2e+02      11      40 ..     277     304 ..     268     305 .. 0.77
   7 ?   -0.2   0.0      0.53   1.2e+03      13      26 ..     340     353 ..     337     356 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.0 bits;  conditional E-value: 0.00031
                HHHHHHTTHHHHHHHHTT.TSSHHHH CS
         Arm  5 kdavieaGavppLvrLLs.sedeevq 29
                 +++ e+G++  L++LL+ s d++++
  EFC39793.1 63 AEELLEMGGISTLLELLHdSLDPRIC 88
                57899*****************9985 PP

  == domain 2  score: 18.6 bits;  conditional E-value: 6.1e-07
                 SHHHHHHHHHTTHHHHHHHHTT..TSSHHHHHHHHHHHHHHT CS
         Arm   1 nsenkdavieaGavppLvrLLs..sedeevqeeAawALsNLa 40 
                 n+e++++++ +G+v   +rLL+   + +  +e A++AL NL 
  EFC39793.1  97 NDECREEIVAQGGVSEVCRLLKkkVDETLAVEYATGALLNLV 138
                 79**************************************95 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.13
                 THHHHHHHHTT.TSSHHHHHHHHHHHHHH CS
         Arm  12 GavppLvrLLs.sedeevqeeAawALsNL 39 
                 ++ ++L + L+ + ++e q+++ + +sNL
  EFC39793.1 152 NIFKILGQALEnDLSTEAQTNSISLISNL 180
                 6778899999999***************9 PP

  == domain 4  score: -0.2 bits;  conditional E-value: 0.53
                 TTTSSHHHHHHHHHHHHHHT CS
         Arm  21 LssedeevqeeAawALsNLa 40 
                 L+s + +++  ++ +++N++
  EFC39793.1 202 LNSLHSNIVSLSLNCVWNIC 221
                 67888899999999*****9 PP

  == domain 5  score: 1.4 bits;  conditional E-value: 0.16
                 HHHHHHTTHHHHHHHHTTT CS
         Arm   5 kdavieaGavppLvrLLss 23 
                 ++ + +a+++p+L + Lss
  EFC39793.1 229 TRKLMNANILPALGEALSS 247
                 556779*******999987 PP

  == domain 6  score: 0.9 bits;  conditional E-value: 0.23
                 TTHHHHHHHHTTTSSHHHHHHHHHHHHHHT CS
         Arm  11 aGavppLvrLLssedeevqeeAawALsNLa 40 
                 +  ++  ++L ++ed +  + A +A++N++
  EFC39793.1 277 C--IEEMIELVNCEDLKKATGASTAVWNIS 304
                 4..777788888888888889999****97 PP

  == domain 7  score: -0.2 bits;  conditional E-value: 0.53
                 HHHHHHHHTTTSSH CS
         Arm  13 avppLvrLLssede 26 
                 ++  Lv+LL+ e  
  EFC39793.1 340 VLSCLVTLLTKEES 353
                 7899*****95544 PP

>> SIL1  Nucleotide exchange factor SIL1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.4   0.0   1.5e-05     0.033      93     216 ..      18     153 ..       7     171 .. 0.67
   2 ?    1.9   0.1     0.048   1.1e+02      81     173 ..      96     186 ..      89     199 .. 0.67
   3 !    4.4   0.4     0.008        18      99     155 ..     316     375 ..     297     378 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.5e-05
        SIL1  93 kpefvkelfeelselsk.....kksdvliKRylsilqeLlqnsefvtkyekkskletLieiyeikdkqikikvlelledllleeee............. 173
                 +p+fv +l e l+el+k     ++++   K++++i+  L +++e++++  +  +++tL e+   + +++  ++  +l ++ +++e              
  EFC39793.1  18 RPNFVGSLEESLKELKKklstgNSQTAAWKKVIGIIFSLSTEDETAEELLEMGGISTLLEL---LHDSLDPRICGILLNVSNNDECreeivaqggvsev 113
                 489999999999999999999999*******************999999444455555555...55555556666666666555444456777776543 PP

        SIL1 174 ksevkkrsaeeeeedvqewaselskfiqdkeidelhvrkfFns 216
                    +kk ++ +e+  v+  +  l +++qd+++ e ++ k+ n 
  EFC39793.1 114 CRLLKK-KV-DETLAVEYATGALLNLVQDEKSRE-DFIKYSNI 153
                 222233.22.334467788888888888777776.44444444 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.048
        SIL1  81 NNpeavenvlekkpefvkelfeelselskkksdvli.KRylsilqeLlqnsefvtky.ekkskletLieiy.eikdkqikikvlelledllleeee 173
                 NN e+ e+++ +    v+e++  l++   k +++l+     + l +L+q++++ +++ + ++ ++ L +   + ++ ++++  ++l+++l +++ e
  EFC39793.1  96 NNDECREEIVAQG--GVSEVCRLLKK---KVDETLAvEYATGALLNLVQDEKSREDFiKYSNIFKILGQALeNDLSTEAQTNSISLISNLIMDRAE 186
                 6666666666544..35555555544...3334444044457888999998777777666778999999995558999999999999999998855 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.008
        SIL1  99 elfeelselsk....kksdvliKRylsilqeLlqnsefvtkyekkskletLieiyeikdkq 155
                 ++++ ls+l +    +k+     ++ls l  Ll+++e++ +y   ++ + Li++y++++ +
  EFC39793.1 316 KTLSSLSKLLEsvlkEKDIKSVEKVLSCLVTLLTKEESMVEY-FVNDRNGLIQVYKLLETE 375
                 3444444433344436666677889********999999999.566999999999988766 PP

>> CK2S  Casein Kinase 2 substrate
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.0     0.053   1.2e+02      66     105 ..      23      62 ..      18      80 .. 0.84
   2 !    6.3   0.0    0.0036         8      66     102 ..     251     287 ..     205     301 .. 0.81
   3 !    6.2   0.1    0.0039       8.8      54     101 ..     323     370 ..     302     388 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.053
        CK2S  66 ealeevlakLrekleelqkvrdsleklvrdalqlyeekad 105
                  +lee l++L++kl++ ++ + +++k     ++l  e+  
  EFC39793.1  23 GSLEESLKELKKKLSTGNSQTAAWKKVIGIIFSLSTEDET 62 
                 589***********************99999988877666 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0036
        CK2S  66 ealeevlakLrekleelqkvrdsleklvrdalqlyee 102
                 e + + l++++ ++e++++++d+l++  ++  +l++ 
  EFC39793.1 251 EDAGNCLVCMSMVMEHVDELTDDLKECIEEMIELVNC 287
                 5566789********************9999999874 PP

  == domain 3  score: 6.2 bits;  conditional E-value: 0.0039
        CK2S  54 pdlqerLrekqlealeevlakLrekleelqkvrdsleklvrdalqlye 101
                 + l++ L ek ++++e+vl +L   l++ +++++ + + ++   q+y+
  EFC39793.1 323 KLLESVLKEKDIKSVEKVLSCLVTLLTKEESMVEYFVNDRNGLIQVYK 370
                 337889*********************999999999988887777776 PP

>> DUF3361  Domain of unknown function (DUF3361)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.6   1.8e-05     0.039       3     133 ..      63     189 ..      62     237 .. 0.79
   2 ?    3.6   1.5     0.026        58      25     127 ..     249     350 ..     228     362 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 1.8e-05
     DUF3361   3 AqeFisrdGlkllvkiveegkesgeilayaLtafleLmdhgivsWdtlsdeFikkiasivnksaadasilqrslaiLesivlnsselyelvekevtles 101
                 A+e ++++G+++l+++++++  + +    +   +l++ + + +  +++ +  +++++  ++k+  ++  ++ ++  L ++v+ +++  + ++    ++ 
  EFC39793.1  63 AEELLEMGGISTLLELLHDS-LDPR----ICGILLNVSNNDECREEIVAQGGVSEVCRLLKKKVDETLAVEYATGALLNLVQDEKSREDFIKYSNIFKI 156
                 56777777777777777776.2233....3333455666667777888888899999999999777888999*************************** PP

     DUF3361 102 LiehLqssnqe.iqtnalaLlnALllkaddskr 133
                 L + L+++ ++  qtn+++L+  L++   +s r
  EFC39793.1 157 LGQALENDLSTeAQTNSISLISNLIMDRAESIR 189
                 *****8775544*********999987665544 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.026
     DUF3361  25 sgeilayaLtafleLmdhgivsWdtlsdeFikkiasivnksaad.asilqrslaiLesivlnsselyelvekevt..lesLie.hLqssnqeiqtnala 119
                 +ge   ++L ++  +m+h     d l+ e+i+++++ vn +  d ++ + +s+a+ + i +n++ l + ++++    l++L+e  L++++ +   ++l+
  EFC39793.1 249 EGEDAGNCLVCMSMVMEHVDELTDDLK-ECIEEMIELVNCE--DlKKATGASTAVWN-ISQNDY-LASCISNKTLssLSKLLEsVLKEKDIKSVEKVLS 342
                 6677788999999*****888888885.79*********99..43455566666655.555555.6666666543333343331344455556667777 PP

     DUF3361 120 LlnALllk 127
                  l +Ll+k
  EFC39793.1 343 CLVTLLTK 350
                 77777766 PP

>> DUF5578  Family of unknown function (DUF5578)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   1.0   3.4e-05     0.077      81     114 ..      48      81 ..      37     234 .. 0.87
   2 ?    1.1   0.1     0.098   2.2e+02     153     195 ..     306     349 ..     275     358 .. 0.81
   3 ?   -0.7   0.0      0.33   7.4e+02      99     119 ..     412     432 ..     390     437 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.4e-05
     DUF5578  81 kaigiflsaasgkrylieFlEiGGvltlleilgl 114
                 k igi  s ++ ++   e lE+GG+ tlle+l  
  EFC39793.1  48 KVIGIIFSLSTEDETAEELLEMGGISTLLELLHD 81 
                 789****************************964 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.098
     DUF5578 153 aeclakskseetqeeaqkllesla.egnPkyqkqvykglialla 195
                  ++la++ s++t ++ +klles+  e + k  ++v + l++ll+
  EFC39793.1 306 NDYLASCISNKTLSSLSKLLESVLkEKDIKSVEKVLSCLVTLLT 349
                 56899999999999999999986514566777777777777765 PP

  == domain 3  score: -0.7 bits;  conditional E-value: 0.33
     DUF5578  99 FlEiGGvltlleilglkqlke 119
                  lEiG v  ll++++lkq++ 
  EFC39793.1 412 LLEIGIVTELLDLITLKQVST 432
                 69**************99875 PP

>> RTP1_C1  Required for nuclear transport of RNA pol II C-terminus 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.1      0.29   6.4e+02      24      51 ..     135     163 ..     105     181 .. 0.62
   2 ?    0.7   0.0      0.26   5.8e+02      14      81 ..     168     234 ..     159     247 .. 0.82
   3 ?    8.1   0.3    0.0013       2.8      18      76 ..     316     377 ..     307     393 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.29
     RTP1_C1  24 rkli.ekkskeavldiekilkllleaLkd 51 
                  +l+  +ks+e+ ++ ++i+k+l +aL++
  EFC39793.1 135 LNLVqDEKSREDFIKYSNIFKILGQALEN 163
                 22220234444666666777776666665 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.26
     RTP1_C1  14 pvrahglvlLrkliekkskeavldiekilkllleaLkdedsYvYLnaikgLvaLadvfpeevlklLle 81 
                   +++ ++l+++li ++  e++ d e++++ +   L+   s +   + +++ +++   +ee++++L++
  EFC39793.1 168 EAQTNSISLISNLIMDRA-ESIRDNEEMFSAIACGLNSLHSNIVSLSLNCVWNICVERDEEITRKLMN 234
                 567788999999999997.8888889999988888888888888888888888888888888888876 PP

  == domain 3  score: 8.1 bits;  conditional E-value: 0.0013
     RTP1_C1  18 hglvlLrkliekkske.avldiekilkllleaLkdedsYv..YLnaikgLvaLadvfpeevl 76 
                 + l++L+kl+e+  ke +++++ek+l+ l++ L++e+s v  ++n  +gL ++ +  ++e+l
  EFC39793.1 316 KTLSSLSKLLESVLKEkDIKSVEKVLSCLVTLLTKEESMVeyFVNDRNGLIQVYKLLETEIL 377
                 67899999999876555999******************986666666777766666666665 PP

>> REV1_C  DNA repair protein REV1 C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.96   2.1e+03      17      45 ..     104     132 ..      98     174 .. 0.58
   2 ?   -2.2   0.1       2.6   5.8e+03      21      37 ..     265     281 ..     262     298 .. 0.65
   3 ?    8.8   0.1   0.00094       2.1      24      57 ..     319     351 ..     307     373 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.96
      REV1_C  17 gPneeDvealakyLkkvveeerdlekava 45 
                    +  v  +++ Lkk v e   +e a+ 
  EFC39793.1 104 IVAQGGVSEVCRLLKKKVDETLAVEYATG 132
                 55555555555556655555555544443 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 2.6
      REV1_C  21 eDvealakyLkkvveee 37 
                 e v+ l++ Lk+++ee 
  EFC39793.1 265 EHVDELTDDLKECIEEM 281
                 56777888888888333 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00094
      REV1_C  24 ealakyLkkvveeerdlekavavlkwlrvlleee 57 
                   l+k L++v+ +e+d++ +++vl +l  ll +e
  EFC39793.1 319 SSLSKLLESVL-KEKDIKSVEKVLSCLVTLLTKE 351
                 56889999999.99**************999998 PP

>> SYCP2_ARLD  Synaptonemal complex 2 armadillo-repeat-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.3   0.2      0.28   6.2e+02      19      64 ..     136     182 ..     117     204 .. 0.57
   2 ?    1.9   0.1     0.086   1.9e+02      47      81 ..     201     235 ..     192     248 .. 0.79
   3 ?   11.3   3.5   0.00012      0.26      29     137 ..     310     415 ..     298     434 .. 0.67

  Alignments for each domain:
  == domain 1  score: 0.3 bits;  conditional E-value: 0.28
  SYCP2_ARLD  19 ellq.ekeeevsqkyskqllnkLdklinkeLdkn.efknvsllLkciq 64 
                 +l+q ek++e  +kys+ +++ L +++ ++L  + + +++sl+ + i 
  EFC39793.1 136 NLVQdEKSREDFIKYSN-IFKILGQALENDLSTEaQTNSISLISNLIM 182
                 45554555555556654.445555555555544313344555544444 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.086
  SYCP2_ARLD  47 eLdknefknvsllLkciqkflkndgeeglsllikq 81 
                  L+    + vsl L+c+ +++ + +ee +  l++ 
  EFC39793.1 201 GLNSLHSNIVSLSLNCVWNICVERDEEITRKLMNA 235
                 5666666789***********99888887777665 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 0.00012
  SYCP2_ARLD  29 sqkyskqllnkLdklinkeLdknefknvsllLkciqkflkndgeeglslli..kqgLvqkmvswfekakeflileenekneslinliEdffdvalvisk 125
                    +s++ l+ L kl+   L ++++k+v  +L c+  +l+++++   + ++  + gL+q + + +e+  e+l +   +++++      df  ++  i+ 
  EFC39793.1 310 ASCISNKTLSSLSKLLESVLKEKDIKSVEKVLSCLVTLLTKEES-MVEYFVndRNGLIQ-VYKLLET--EILSIPIYQEEST-YRKCLDFSIMISCICS 403
                 55678999***************************999988443.33444422678887.4455553..4444433333333.3344477777777777 PP

  SYCP2_ARLD 126 isseGkiqllds 137
                   +eG + ll+ 
  EFC39793.1 404 EIKEGEKALLEI 415
                 778888877775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (438 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       881  (0.0491383); expected 358.6 (0.02)
Passed bias filter:                      491  (0.0273858); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.64u 0.28s 00:00:00.92 Elapsed: 00:00:00.49
# Mc/sec: 2700.10
//
Query:       EFC39794.1  [L=309]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    2.1e-32  112.3   8.9    2.7e-32  111.9   8.9    1.1  1  Reticulon        Reticulon
  ------ inclusion threshold ------
       0.86   10.0   3.7        5.7    7.4   0.8    3.0  3  Bombolitin       Bombolitin family


Domain annotation for each model (and alignments):
>> Reticulon  Reticulon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  111.9   8.9     3e-36   2.7e-32       2     156 ..     117     274 ..     116     275 .. 0.97

  Alignments for each domain:
  == domain 1  score: 111.9 bits;  conditional E-value: 3e-36
   Reticulon   2 adlllWrnkkksgivlgglllllllfellgysllslvsklllllllvlflwaeyagllnkskp...pepelelseesvreladsllellnkalselrrl 97 
                 ad+l+Wrn  +++ v++++ +l+ll++ ++++l++l+ k++++ +l+++ + ++ ++++ +++   p +++e+s+e v+++++ +++++n++l+   ++
  EFC39794.1 117 ADILMWRNIFVTVPVFLAIQALFLLLCKYEFTLVNLIGKVVFIQVLISVGYMVVFKIIQNNPNhtfPFQNVEISQELVNKIVTGIVANVNSGLKYYLDI 215
                 8***********************************************************85557777******************************* PP

   Reticulon  98 algedlklflkvalllyilsilgslfslltllyigvvlaftvPllYekyedeIdalvek 156
                 ++ ++l ++l + ++++i+s+lg+ + + t+ly+++ ++ft+Pl+Ye+++deId++++ 
  EFC39794.1 216 LSCKELGKTLAFGVVVLIVSWLGKKMAGETFLYLALNVLFTLPLIYEWKQDEIDSVLKI 274
                 *******************************************************9986 PP

>> Bombolitin  Bombolitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.7   0.0     0.043   3.9e+02       5      15 ..     214     226 ..     212     227 .. 0.73
   2 ?   -3.3   0.0       1.7   1.5e+04       9      15 ..     236     242 ..     233     242 .. 0.67
   3 ?    7.4   0.8   0.00063       5.7       5      11 ..     296     302 ..     294     303 .. 0.93

  Alignments for each domain:
  == domain 1  score: 1.7 bits;  conditional E-value: 0.043
  Bombolitin   5 DILA..KLGKVLA 15 
                 DIL    LGK LA
  EFC39794.1 214 DILSckELGKTLA 226
                 77754349***99 PP

  == domain 2  score: -3.3 bits;  conditional E-value: 1.7
  Bombolitin   9 KLGKVLA 15 
                  LGK +A
  EFC39794.1 236 WLGKKMA 242
                 5999665 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.00063
  Bombolitin   5 DILAKLG 11 
                 DILAKLG
  EFC39794.1 296 DILAKLG 302
                 ******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (309 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1014  (0.0565564); expected 358.6 (0.02)
Passed bias filter:                      492  (0.0274416); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.30s 00:00:00.87 Elapsed: 00:00:00.48
# Mc/sec: 1931.72
//
Query:       EFC39795.1  [L=522]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    7.1e-36  123.9   0.0      1e-35  123.4   0.0    1.2  1  BCS1_N        BCS1 N terminal
    4.9e-15   56.1   0.0    1.6e-13   51.2   0.0    2.3  1  AAA           ATPase family associated with various cellular 
    0.00022   21.6   0.0    0.00044   20.7   0.0    1.5  1  AAA_16        AAA ATPase domain
     0.0018   18.3   0.0     0.0036   17.3   0.0    1.5  1  AAA_5         AAA domain (dynein-related subfamily)
      0.002   17.1   0.0     0.0031   16.5   0.0    1.2  1  AAA_6         Hydrolytic ATP binding site of dynein motor reg
     0.0024   17.1   0.0      0.004   16.3   0.0    1.2  1  DUF815        Protein of unknown function (DUF815)
     0.0049   16.7   0.0      0.008   16.0   0.0    1.3  1  AAA_11        AAA domain
  ------ inclusion threshold ------
      0.012   15.4   0.0       0.02   14.6   0.0    1.4  1  AAA_24        AAA domain
      0.017   14.6   0.0      0.032   13.7   0.0    1.4  1  AAA_7         P-loop containing dynein motor region
      0.046   14.1   0.0       0.11   12.9   0.0    1.7  1  RNA_helicase  RNA helicase
      0.046   14.2   0.0       0.39   11.2   0.0    2.3  2  ABC_tran      ABC transporter
      0.051   13.3   0.0      0.099   12.4   0.0    1.4  1  RuvB_N        Holliday junction DNA helicase RuvB P-loop doma
      0.062   13.6   0.0       0.18   12.1   0.0    1.8  1  AAA_22        AAA domain
      0.075   13.6   0.0       0.25   11.9   0.0    1.9  2  AAA_18        AAA domain
      0.093   12.1   0.0       0.15   11.4   0.0    1.2  1  ATPase        KaiC
       0.11   12.7   0.1       0.23   11.7   0.1    1.4  1  AAA_28        AAA domain
       0.21   11.3   0.0       0.35   10.6   0.0    1.2  1  AAA_30        AAA domain


Domain annotation for each model (and alignments):
>> BCS1_N  BCS1 N terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  123.4   0.0   9.9e-39     1e-35       9     187 .]      80     254 ..      72     254 .. 0.87

  Alignments for each domain:
  == domain 1  score: 123.4 bits;  conditional E-value: 9.9e-39
      BCS1_N   9 rrllselaslirrrflvsveissdDeaydwvlaWlsaqpasrrsrelsvetrtksrssdssaeedededeeedgkkkkplrylPavgtthlfrykgrll 107
                 + ++s++  l++++f+++++i+++Deay+w+++Wl++ + s++s++l++ +++++ + +s +++ ++     ++k++ p++++P++g  h++++kg+ +
  EFC39795.1  80 TFWYSSINYLFQKNFVSKLQINNNDEAYHWFMYWLAEDSYSQDSNHLAILASKTHFDFSSFKHNPSE-----KDKHSVPIKFIPSPG-IHYLKFKGKTI 172
                 5567888889***************************************999888876666555322.....235799*********.7********** PP

      BCS1_N 108 avtRereekssdsetga....peetltltclgrsreilkeLleearelalkkqegktviyraaagsggeWrrvasRpkRplstV 187
                  ++ er+ +s  s   +    p e+++++cl+ s++ lke++ ++++++l++++gkt iy +  ++   W++  s+ kRp stV
  EFC39795.1 173 KISYERNLSSGASLG-SspnsPSEQIEISCLATSPNFLKEFIIDCQQKYLESKHGKTLIYLPD-SYCDFWEPRISKLKRPPSTV 254
                 ***999555444333.357789***************************************88.89*****************9 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.2   0.0   1.5e-16   1.6e-13       2     130 ..     290     436 ..     289     438 .. 0.80

  Alignments for each domain:
  == domain 1  score: 51.2 bits;  conditional E-value: 1.5e-16
                 EEESSTTSSHHHHHHHHHHHHTHEEEEEETTTCSSSSTTHHHHHHHHHHHHHHHTSTSEEEEEETGGGHHHHH.......................... CS
         AAA   2 llyGppGtGKTllakavakelgvefleisgsellskyvgesekkirelfkeakekakpsilfiDEidalaksr.......................... 74 
                 llyGppGtGKT+++ a+a  l+ +++ i+ s+        + ++++ l+ +   +   si+++++ida +++                           
  EFC39795.1 290 LLYGPPGTGKTSTVTALAGALDKNICCINISNKN-----LNDDNLNSLLLNTPFN---SIILLEDIDACFSAPikmerkqtrpphpsqpeasddnsvse 380
                 9********************8887666666666.....55999***99886554...7***********99988999999999987777777665543 PP

                 TTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEESSGGGSTHHHHS.TTSSEEEET CS
         AAA  75 sgseseeeervvnqLlteldgvkkkeskvivigatnrpdkldpallr.gRfdrkiei 130
                  +++ + ++ ++  Ll+ +dgv  +e+  i+ ++tn++d+l++al+r gR+d+k+ i
  EFC39795.1 381 LSTHGTGSNVTLGGLLNCIDGVVAQEG-RILFMTTNHIDRLPDALIRpGRIDVKYLI 436
                 333445556667778888888777655.9999*********************9877 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   0.0   4.1e-07   0.00044      25      63 ..     287     324 ..     278     424 .. 0.65

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 4.1e-07
      AAA_16  25 elvllsGesGvGKsslvrellralekdggiflrgkcdql 63 
                 +  ll+G++G+GK+s v++l+ al k+ + +++  ++ l
  EFC39795.1 287 RGYLLYGPPGTGKTSTVTALAGALDKN-ICCINISNKNL 324
                 778******************999988.66666666555 PP

>> AAA_5  AAA domain (dynein-related subfamily)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   3.4e-06    0.0036       3      34 ..     290     321 ..     288     333 .. 0.85

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 3.4e-06
                 EEE--SSSSHHHHHHHGGGGBS--EEEEE--T CS
       AAA_5   3 lLvGppGtgKselaerlaaalnreveyvqltr 34 
                 lL GppGtgK++ +  la al +++  ++++ 
  EFC39795.1 290 LLYGPPGTGKTSTVTALAGALDKNICCINISN 321
                 9********************99988887754 PP

>> AAA_6  Hydrolytic ATP binding site of dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   0.0     3e-06    0.0031      34      68 ..     288     322 ..     281     333 .. 0.87

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 3e-06
       AAA_6  34 ggapaGpagtGKtEtvkdLakalakqvvvfncsdq 68 
                 g  ++Gp gtGKt tv  La al k ++ +n+s++
  EFC39795.1 288 GYLLYGPPGTGKTSTVTALAGALDKNICCINISNK 322
                 56689**************************9975 PP

>> DUF815  Protein of unknown function (DUF815)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   3.8e-06     0.004      56     116 ..     289     347 ..     285     355 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 3.8e-06
      DUF815  56 vLLwGarGtGKSslvkallneyaeegLrlievekedlkelpklvellrerperfilfvDDL 116
                  LL+G  GtGK s+v al  ++ ++++  i++++++l++ ++l +ll ++p + i+++ D+
  EFC39795.1 289 YLLYGPPGTGKTSTVTALAGAL-DKNICCINISNKNLND-DNLNSLLLNTPFNSIILLEDI 347
                 59***************98877.567999********98.89999999***9999999986 PP

>> AAA_11  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   7.6e-06     0.008      20      45 ..     289     320 ..     278     360 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 7.6e-06
      AAA_11  20 tliqGPPGtgKTktivellsqllsr......r 45 
                  l+ GPPGtgKT+t+++l  +l ++      +
  EFC39795.1 289 YLLYGPPGTGKTSTVTALAGALDKNicciniS 320
                 5899**************99995434444432 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.6   0.0   1.9e-05      0.02       5      44 ..     289     330 ..     286     357 .. 0.84

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.9e-05
      AAA_24   5 iliyGpsgiGKTtlakel....gpkplfidtekGlksldadkfp 44 
                 +l+yGp+g+GKT++++ l     +++ +i++ +  k+l++d+++
  EFC39795.1 289 YLLYGPPGTGKTSTVTALagalDKNICCINISN--KNLNDDNLN 330
                 689*************99998888888888877..777777765 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.0     3e-05     0.032      33      67 ..     286     319 ..     265     332 .. 0.82

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 3e-05
       AAA_7  33 kkpvllvGptGtGKtviikdllkkldkekylslti 67 
                 ++  ll+Gp GtGKt++++ l  +ldk+ + +++i
  EFC39795.1 286 RRGYLLYGPPGTGKTSTVTALAGALDKNIC-CINI 319
                 66789*********************5444.3333 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.0   0.00011      0.11       2      26 ..     290     314 ..     289     342 .. 0.82

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 0.00011
  RNA_helicase   2 wlyGpsgeGKStlakeLakallkkl 26 
                   +lyGp+g+GK+++++ La al k++
    EFC39795.1 290 LLYGPPGTGKTSTVTALAGALDKNI 314
                   69*****************999888 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0       1.6   1.7e+03      57      80 ..      82     121 ..      63     184 .. 0.68
   2 ?   11.2   0.0   0.00037      0.39      14      55 ..     289     330 ..     283     338 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 1.6
                 CCHCEEEE-SS--S-TTSBHHHH.................H CS
                 xxxxxxxxxxxxxxxxxxxxxxx.................x RF
    ABC_tran  57 lrkeigvlpqepqlfpeltvren.................e 80 
                 + ++i +l+q+ ++ ++l++ +n                 +
  EFC39795.1  82 WYSSINYLFQK-NFVSKLQINNNdeayhwfmywlaedsysQ 121
                 56788999999.45555556666667777777666655431 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00037
                 EEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkpteGeilldgkdlkeqele 55 
                 + + G+ G+GK++ + +lag l+++   i++ +k+l++++l+
  EFC39795.1 289 YLLYGPPGTGKTSTVTALAGALDKNICCINISNKNLNDDNLN 330
                 5689********************999999999999997765 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   9.4e-05     0.099      37      93 ..     290     347 ..     286     353 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 9.4e-05
      RuvB_N  37 llyGpPGlGkttlakiiakelgvklkitsgPvle.kagdlaalltnleekdvlfidei 93 
                 llyGpPG Gkt+  + +a  l+ ++        + +  +l +ll n   + ++++++i
  EFC39795.1 290 LLYGPPGTGKTSTVTALAGALDKNICCINISNKNlNDDNLNSLLLNTPFNSIILLEDI 347
                 8********************9998754433222134567788877777777777666 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   0.00017      0.18       8      31 ..     289     312 ..     286     354 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 0.00017
      AAA_22   8 lvvtGesGtGKTtllrrlleqlde 31 
                  +++G++GtGKT ++  l+  ld+
  EFC39795.1 289 YLLYGPPGTGKTSTVTALAGALDK 312
                 589**************9999853 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00023      0.25       2      28 ..     290     329 ..     290     361 .. 0.75
   2 ?   -2.5   0.0       6.7   7.1e+03      30      69 ..     451     490 ..     436     514 .. 0.62

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00023
      AAA_18   2 lltGtpGvGKttlakeLskrl.gf............gvnl 28 
                 ll G+pG+GKt+   +L+  l ++             +nl
  EFC39795.1 290 LLYGPPGTGKTSTVTALAGALdKNiccinisnknlnDDNL 329
                 589**************88876666775555333343333 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 6.7
      AAA_18  30 dvakenglllevdpealdeskrldedkldklldaleenss 69 
                 ++ +e ++ + + ++ + e+k++++  +++l+  ++ +  
  EFC39795.1 451 FYPREYDCADLFCAKIFAEHKEIRRFTCAELQGHFMSHKH 490
                 4445555555555556777888888888888888777743 PP

>> ATPase  KaiC
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.4   0.0   0.00015      0.15       7      35 ..     273     302 ..     268     320 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.4 bits;  conditional E-value: 0.00015
      ATPase   7 glDeil.kgGipegrvvlitGepGtGKtif 35 
                 gl++   + Gip +r +l++G pGtGKt  
  EFC39795.1 273 GLEKWYnDHGIPFRRGYLLYGPPGTGKTST 302
                 567777679******************965 PP

>> AAA_28  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   0.00022      0.23       3      21 ..     290     308 ..     289     321 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00022
      AAA_28   3 vitGgestGKTtlleaLaa 21 
                  + G+++tGKT+++ aLa 
  EFC39795.1 290 LLYGPPGTGKTSTVTALAG 308
                 589**************94 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00033      0.35      22      44 ..     290     312 ..     286     319 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00033
      AAA_30  22 vltGpAGtGKttalkalreawea 44 
                 +l Gp+GtGKt +++al+ a+++
  EFC39795.1 290 LLYGPPGTGKTSTVTALAGALDK 312
                 688*************9988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (522 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       659  (0.0367561); expected 358.6 (0.02)
Passed bias filter:                      558  (0.0311228); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              17  [number of targets reported over threshold]
# CPU time: 0.71u 0.35s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 2906.75
//
Query:       EFC39796.1  [L=1165]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    7.2e-38  127.8  46.3      4e-10   39.1   4.3    6.8  7  Pentapeptide    Pentapeptide repeats (8 copies)
    2.3e-28   98.2  43.2    1.3e-12   47.7   1.2    5.5  6  Pentapeptide_4  Pentapeptide repeats (9 copies)
    1.5e-13   50.6  34.7    3.9e-07   30.1   0.9    5.6  7  Pentapeptide_3  Pentapeptide repeats (9 copies)
    1.8e-05   25.0   0.2    0.00017   21.9   0.0    2.6  2  BTB_2           BTB/POZ domain
     0.0024   18.1   0.7     0.0024   18.1   0.7    3.2  3  RGS             Regulator of G protein signaling domain
  ------ inclusion threshold ------
        7.8    6.4   9.9        0.1   12.5   0.5    2.7  4  Prefoldin       Prefoldin subunit


Domain annotation for each model (and alignments):
>> Pentapeptide  Pentapeptide repeats (8 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.5   0.0    0.0046        14      11      40 .]     518     547 ..     517     547 .. 0.95
   2 !   39.1   4.3   1.3e-13     4e-10       2      39 ..     549     586 ..     549     586 .. 0.98
   3 !   37.0   9.3   6.3e-13   1.9e-09       2      40 .]     584     622 ..     583     622 .. 0.98
   4 ?    2.8   0.0     0.032        94      15      26 ..     629     640 ..     628     644 .. 0.41
   5 !   31.3   4.1   3.9e-11   1.2e-07       3      40 .]     653     690 ..     653     690 .. 0.97
   6 !   32.1   4.2   2.2e-11   6.5e-08       3      39 ..     693     729 ..     693     729 .. 0.98
   7 ?   -3.0   0.0         2     6e+03      29      36 ..     741     748 ..     740     749 .. 0.45

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0046
                   SCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide  11 anLsganlsgAnLtgAnlsgAdLsganLsg 40 
                    +Ls+ +l+  +L + ++++ + +++++sg
    EFC39796.1 518 VKLSNIDLKLVSLKDLDIRKIQITDSDFSG 547
                   58**************************98 PP

  == domain 2  score: 39.1 bits;  conditional E-value: 1.3e-13
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEEC CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLs 39 
                   nLs++n+sg+nL+g+ ++ AnL +Anl+ +dL+ +n++
    EFC39796.1 549 NLSEVNFSGCNLRGCTFEKANLAHANLTLCDLRYTNFT 586
                   9************************************7 PP

  == domain 3  score: 37.0 bits;  conditional E-value: 6.3e-13
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   n++ AnL+g +L ganlsgA ++++n+++++L+g++L++
    EFC39796.1 584 NFTSANLTGGSLGGANLSGALFDNTNFTNTNLKGCDLTN 622
                   9************************************97 PP

  == domain 4  score: 2.8 bits;  conditional E-value: 0.032
                   ECCCESEEECT- CS
  Pentapeptide  15 ganlsgAnLtgA 26 
                   g+ ls+A++++A
    EFC39796.1 629 GCVLSNAKMNRA 640
                   333333333333 PP

  == domain 5  score: 31.3 bits;  conditional E-value: 3.9e-11
                   -TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEECT CS
  Pentapeptide   3 LsgAnLsganLsganlsgAnLtgAnlsgAdLsganLsg 40 
                   L g++Lsg+++++ n+s+ +L+++n+s++ L+++++++
    EFC39796.1 653 LFGVDLSGCSMKQFNFSNMDLSSSNFSNTILNQSDFTN 690
                   679*********************************97 PP

  == domain 6  score: 32.1 bits;  conditional E-value: 2.2e-11
                   -TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEEC CS
  Pentapeptide   3 LsgAnLsganLsganlsgAnLtgAnlsgAdLsganLs 39 
                   Ls+An+s++++ ++ +s++  tg+ +++++L+++n+s
    EFC39796.1 693 LSNANFSNSSMAECIFSRCLITGTKFINTNLRNCNMS 729
                   89*********************************97 PP

  == domain 7  score: -3.0 bits;  conditional E-value: 2
                   TT-EECCE CS
  Pentapeptide  29 sgAdLsga 36 
                   sgA+L+g+
    EFC39796.1 741 SGAKLNGT 748
                   34444443 PP

>> Pentapeptide_4  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1         2   5.9e+03      12      27 ..     417     433 ..     413     435 .. 0.73
   2 !   17.6   0.0   1.1e-06    0.0033      30      69 ..     517     556 ..     515     557 .. 0.93
   3 !   47.7   1.2   4.5e-16   1.3e-12       3      70 ..     540     607 ..     538     609 .. 0.96
   4 !   35.9   4.6     2e-12     6e-09       3      70 ..     555     622 ..     555     644 .. 0.77
   5 !   22.9   9.0   2.4e-08   7.1e-05      12      77 .]     604     688 ..     599     688 .. 0.67
   6 !   28.3   3.4   5.1e-10   1.5e-06       4      65 ..     684     747 ..     682     760 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2
  Pentapeptide_4  12 klsn.vnFsearlrdcn 27 
                      +++ ++F e +++dc+
      EFC39796.1 417 MFKEvTDFDEEHFIDCD 433
                     56665788888898886 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 1.1e-06
  Pentapeptide_4  30 ecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfs 69 
                     e++lsn  ++  +l+d+d+++++++++ Fsg+nl++vnfs
      EFC39796.1 517 EVKLSNIDLKLVSLKDLDIRKIQITDSDFSGMNLSEVNFS 556
                     578899999999***************************8 PP

  == domain 3  score: 47.7 bits;  conditional E-value: 4.5e-16
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsd 70 
                     +t++ f + +ls+vnFs ++lr+c+F+ ++l ++n++ c+l+ ++f+ ++l+  s+ g nl+++ f++
      EFC39796.1 540 ITDSDFSGMNLSEVNFSGCNLRGCTFEKANLAHANLTLCDLRYTNFTSANLTGGSLGGANLSGALFDN 607
                     7999**************************************************************75 PP

  == domain 4  score: 35.9 bits;  conditional E-value: 2e-12
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsd 70 
                     f+ c +++c+++++n+++a+l  c++++++++++n++  +l  ++++++ + +++F++ nlk++ + +
      EFC39796.1 555 FSGCNLRGCTFEKANLAHANLTLCDLRYTNFTSANLTGGSLGGANLSGALFDNTNFTNTNLKGCDLTN 622
                     67788888888888888888888888888888888777777777777777777777777777777643 PP

  == domain 5  score: 22.9 bits;  conditional E-value: 2.4e-08
  Pentapeptide_4  12 klsnvnFsearlrdcnFtecrl.......snvn...........FdecnlsdvdfaevdlkrasFsgcnlknvnfsd.klkdidF 77 
                      ++n+nF++++l++c++t++         sn++            +  +l  vd++++++k  +Fs+++l+++nfs+  l++ dF
      EFC39796.1 604 LFDNTNFTNTNLKGCDLTNIASestgcvlSNAKmnrakvneeflRSAKTLFGVDLSGCSMKQFNFSNMDLSSSNFSNtILNQSDF 688
                     4555555555555555555555444444433334444455665467788889***********************7648999988 PP

  == domain 6  score: 28.3 bits;  conditional E-value: 5.1e-10
  Pentapeptide_4   4 trcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkra..sFsgcnlkn 65 
                      ++ f n++lsn+nFs++ + +c F+ c ++ ++F ++nl++++ + +++ ++   +sg  l++
      EFC39796.1 684 NQSDFTNTALSNANFSNSSMAECIFSRCLITGTKFINTNLRNCNMSVINPESTgyFISGAKLNG 747
                     6789****************************************99999888855556666655 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.8   0.1       5.2   1.6e+04      18      30 ..     419     431 ..     418     433 .. 0.46
   2 ?   -3.8   0.0       5.2   1.6e+04      38      46 ..     540     547 ..     534     549 .. 0.60
   3 !   30.1   0.9   1.3e-10   3.9e-07       2      46 ..     551     592 ..     550     594 .. 0.95
   4 !   18.1   2.1   7.6e-07    0.0023       1      39 [.     585     621 ..     585     625 .. 0.85
   5 ?   -2.7   0.0       2.3   6.9e+03       3      18 ..     629     643 ..     628     650 .. 0.67
   6 !   11.6   8.5     8e-05      0.24       2      47 ..     659     701 ..     653     702 .. 0.83
   7 !   15.3   1.8   5.5e-06     0.016       2      38 ..     694     728 ..     693     732 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.8 bits;  conditional E-value: 5.2
  Pentapeptide_3  18 sgaasFsnadFgs 30 
                     +  ++F++ +F +
      EFC39796.1 419 KEVTDFDEEHFID 431
                     4445555555543 PP

  == domain 2  score: -3.8 bits;  conditional E-value: 5.2
  Pentapeptide_3  38 FtgdvdFsg 46 
                     +t d+dFsg
      EFC39796.1 540 IT-DSDFSG 547
                     45.666665 PP

  == domain 3  score: 30.1 bits;  conditional E-value: 1.3e-10
  Pentapeptide_3   2 sganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsg 46 
                     s++nFsg+ ++rg+tF++a +  +a+++ +d++ ++Ft  ++++g
      EFC39796.1 551 SEVNFSGC-NLRGCTFEKA-NLAHANLTLCDLRYTNFT-SANLTG 592
                     899*****.**********.9*****************.999976 PP

  == domain 4  score: 18.1 bits;  conditional E-value: 7.6e-07
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFt 39 
                     F+ an++g  ++ ga+ sga  F+n++F++ ++ g+  t
      EFC39796.1 585 FTSANLTGG-SLGGANLSGAL-FDNTNFTNTNLKGCDLT 621
                     888999999.99999999996.99999999999998766 PP

  == domain 5  score: -2.7 bits;  conditional E-value: 2.3
  Pentapeptide_3   3 ganFsgaadFrgatFs 18 
                     g+++s+a  + +a  +
      EFC39796.1 629 GCVLSNA-KMNRAKVN 643
                     6777777.77776655 PP

  == domain 6  score: 11.6 bits;  conditional E-value: 8e-05
  Pentapeptide_3   2 sganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvdFsga 47 
                     sg+++++  +F++   s++ +Fsn+ ++ +dF ++  + +++Fs++
      EFC39796.1 659 SGCSMKQF-NFSNMDLSSS-NFSNTILNQSDFTNTALS-NANFSNS 701
                     67777888.8888888888.899999999999999999.9999998 PP

  == domain 7  score: 15.3 bits;  conditional E-value: 5.5e-06
  Pentapeptide_3   2 sganFsgaadFrgatFsgaasFsnadFgsadFsgarF 38 
                     s+anFs++ ++ ++ Fs++   +++ F + +++++++
      EFC39796.1 694 SNANFSNS-SMAECIFSRCL-ITGTKFINTNLRNCNM 728
                     78899999.99999999996.7777777777777776 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.71   2.1e+03      25      63 ..     328     363 ..     304     379 .. 0.68
   2 !   21.9   0.0   5.5e-08   0.00017       1      69 [.     387     452 ..     387     473 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.71
                 TTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS. CS
       BTB_2  25 LgkllkteelddydeetneyffDRspklFetiLnyyrtg 63 
                 ++k  +    +  + +t+++ fD s k  e+ L+y+ ++
  EFC39796.1 328 FKKKIN---ESESTCQTKAVVFDQSIKQLESKLEYLSSQ 363
                 333333...344555678899999999999999998875 PP

  == domain 2  score: 21.9 bits;  conditional E-value: 5.5e-08
                 EEEEETTEEEEEEHHHHHTS...TTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-B--- CS
       BTB_2   1 vklnVgGtrfetskstLsrk...pdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtggkLhrp 69 
                 vkl+VgG + ++  stL +    p++ L+++ k  e+ d+   ++e f+D + +lF  iL+++r  gk+ ++
  EFC39796.1 387 VKLDVGGEIINVALSTLLNTeyePTSSLASMFK--EVTDF---DEEHFIDCDVELFLLILHWLRF-GKISVN 452
                 89***************8654458899999988..34444...4568*****************9.777765 PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.6   0.1       4.5   1.3e+04      59      92 ..     234     265 ..     223     267 .. 0.67
   2 ?   -0.3   0.6      0.42   1.2e+03      11      66 ..     305     357 ..     297     388 .. 0.54
   3 !   18.1   0.7   7.9e-07    0.0024      10      81 ..     785     859 ..     776     930 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.6 bits;  conditional E-value: 4.5
                 STTSTTSSTS-HHHHHHHHHHHCSSSTTTTTTHH CS
         RGS  59 apsspkelnidkklreelekrlekeqpsrklfee 92 
                  +s+++ l+++ k+ +++ + +    ++ k++e+
  EFC39796.1 234 CQSCKQVLDLEAKTHNNCGNMFCS--ECLKCMEK 265
                 456666778888888888887777..66666665 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.42
                 HHHHHHHHHHHTTCTHHHHHHHHHHHHHTS..SHHHHHHHHHHHHHHHHTSTTSTTSS CS
         RGS  11 grslFreFlesefseenlsFwlaveefkka..keqeelkkkakeIyneylapsspkel 66 
                 +    r F ++  ++++ s++++v+ + k+  +e+e++ ++  +++++ + ++ +++l
  EFC39796.1 305 L----RGFFKNHMESKCSSYLEEVDVYFKKkiNESESTCQTKAVVFDQSI-KQLESKL 357
                 3....444444444455566666665544434444444444445555545.4444444 PP

  == domain 3  score: 18.1 bits;  conditional E-value: 7.9e-07
                 HHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHC CS
         RGS  10 pgrslFreFlesefseenlsFwlaveefkka...keqeelkkkakeIyneylapsspkelnidkklreelekrle 81 
                 +   l+++F e+ef++en+  w++v ++ ++    +   ++++ +eI + ++ + s+ e+n++++++++  k + 
  EFC39796.1 785 YFYGLLKNFAEKEFASENILIWEKVRTISSNytnYNALVTVEDLREIERDFIRNYSEYEINLSSDCKKKFYKLIF 859
                 5667899*********************999876677777888***********************999776654 PP

>> Prefoldin  Prefoldin subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       4.6   1.4e+04      84     102 ..     120     138 ..     111     145 .. 0.57
   2 ?   12.5   0.5   3.4e-05       0.1      68     115 ..     325     372 ..     324     375 .. 0.94
   3 ?   -1.8   0.4      0.92   2.7e+03      87     110 ..     479     502 ..     469     504 .. 0.85
   4 ?   -3.9   0.0       4.2   1.3e+04      86     109 ..     981    1004 ..     976    1006 .. 0.77

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 4.6
                 HHHHHHHHHHHHHHHHHHH CS
   Prefoldin  84 kkleelekqlekleeelek 102
                  +++ +++q+e++ +++ +
  EFC39796.1 120 PRVAVMNSQQENFRKSIME 138
                 5555555555555555544 PP

  == domain 2  score: 12.5 bits;  conditional E-value: 3.4e-05
                 TEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  68 gyyveksleeAiellkkkleelekqlekleeeleklkdqittleanla 115
                 ++y +k+++e++ +++ k    ++++++le +le+l++q  +le +++
  EFC39796.1 325 DVYFKKKINESESTCQTKAVVFDQSIKQLESKLEYLSSQSRELEGKIS 372
                 79**************************************99997766 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.92
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin  87 eelekqlekleeeleklkdqittl 110
                 + l+++++k+  e+ek+k++i+ +
  EFC39796.1 479 DLLTESITKFGIEIEKKKSRIKHY 502
                 578999999999999999999865 PP

  == domain 4  score: -3.9 bits;  conditional E-value: 4.2
                  HHHHHHHHHHHHHHHHHHHHHHHH CS
   Prefoldin   86 leelekqlekleeeleklkdqitt 109 
                  +e+ +kq++ l  + ++lkdq+ +
  EFC39796.1  981 KEQFRKQFQPLLVNTKELKDQHSS 1004
                  567788888888888999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1165 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1555  (0.086731); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.92u 0.32s 00:00:01.24 Elapsed: 00:00:00.53
# Mc/sec: 6643.86
//
Query:       EFC39797.1  [L=446]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0009   19.0   0.2     0.0027   17.5   0.2    1.9  1  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
     0.0021   18.6   0.1       0.09   13.4   0.0    3.2  3  RCC1      Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.2     3e-07    0.0027       1      30 []     225     254 ..     225     254 .. 0.92

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 3e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 V+++ +Gd+H +aL+ dG+V   GsNs+ Q
  EFC39797.1 225 VTKLECGDFHVLALLKDGTVAVGGSNSSNQ 254
                 67889***************9999999988 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0       0.3   2.7e+03      26      50 .]     161     187 ..     131     187 .. 0.59
   2 !   13.4   0.0     1e-05      0.09      26      50 .]     215     238 ..     197     238 .. 0.83
   3 ?    0.8   0.0     0.088   7.9e+02       2      45 ..     242     282 ..     241     286 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.3
                 EEE-GGGTTS..-EEEEEEETTEEEEE CS
        RCC1  26 Ptkveglsgn..rvvkvacGddhtval 50 
                 P++ ++  g    + ++ c +++++++
  EFC39797.1 161 PRREMPNVGFpyVINHIGCCYSFSCCV 187
                 544444444455566799999999885 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 1e-05
                 EEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1  26 PtkveglsgnrvvkvacGddhtval 50 
                 Pt+++ l+ ++v+k  cGd+h++al
  EFC39797.1 215 PTLIQDLK-KPVTKLECGDFHVLAL 238
                 9*****99.5*************97 PP

  == domain 3  score: 0.8 bits;  conditional E-value: 0.088
                 TEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETT CS
        RCC1   2 GrVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGdd 45 
                 G V   G+n+ +qL    t++ + P  v ++   +++ +++G++
  EFC39797.1 242 GTVAVGGSNSSNQLTSDATHTYNQPFGVLFS---NISNIFSGSN 282
                 5666669999****99999999999999665...7888888877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (446 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       478  (0.0266607); expected 358.6 (0.02)
Passed bias filter:                      341  (0.0190195); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.27s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 2833.30
//
Query:       EFC39798.1  [L=454]
Description: esterase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.8e-13   48.6   0.1    3.8e-12   46.5   0.0    1.9  2  Abhydrolase_3  alpha/beta hydrolase fold
    1.9e-10   40.2   0.0      2e-09   36.8   0.0    2.1  1  Say1_Mug180    Steryl acetyl hydrolase
    0.00032   20.1   0.0    0.00056   19.4   0.0    1.4  1  DUF2235        Uncharacterized alpha/beta hydrolase domain (D
     0.0051   16.7   0.0       0.02   14.8   0.0    2.0  1  Lipase_3       Lipase (class 3)
  ------ inclusion threshold ------
      0.014   14.9   0.1      0.032   13.7   0.1    1.6  1  Peptidase_S9   Prolyl oligopeptidase family
      0.024   13.9   0.0      0.072   12.4   0.0    1.7  2  Hydrolase_4    Serine aminopeptidase, S33
      0.048   13.2   0.0      0.098   12.2   0.0    1.4  1  DUF3089        Protein of unknown function (DUF3089)
       0.05   13.6   0.0        6.4    6.7   0.0    2.4  2  UPF0227        Uncharacterised protein family (UPF0227)


Domain annotation for each model (and alignments):
>> Abhydrolase_3  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.2      0.54   1.2e+03       1       9 [.     212     220 ..     212     255 .. 0.71
   2 !   46.5   0.0   1.7e-15   3.8e-12      44     209 ..     272     431 ..     270     433 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.54
                    EEEE--STT CS
  Abhydrolase_3   1 lvyfHGGGf 9  
                    l+y+HGGG 
     EFC39798.1 212 LFYIHGGGG 220
                    6899*9985 PP

  == domain 2  score: 46.5 bits;  conditional E-value: 1.7e-15
                    -TTHHHHHHHHHHHHHHHTHHHHTETTCEEEEEEETHHHHHHHHHHHHHHHTT---..EEEEEEESE-SSTSSTTSHHHHHCHHTTTSSSSCHHHH CS
  Abhydrolase_3  44 pfPaavedalaalrwlaeqawelgadpsrivlaGdSaGGnlaaavalrardegepk..vagqvliyPvtdlertesesikkaeeladgplltraal 137
                     f  +++d+++a++wl e+     +dp+ iv++GdS GG  +a+++ ++ +e +++  +   v ++   d+   + +s++++ + ++  +  ++++
     EFC39798.1 272 SFEEQLQDCMDAYKWLIEK-----YDPKDIVFMGDSFGGAVVANLLAKIGAELGIEkqPYMAVTLSGFFDT---TVKSFREHFDIENSVIAAPNNI 359
                    588899************9.....9*********************9999984333448888888887655...446664443447777789**** PP

                    HHHHHHHSS.GGGGGSTTTSGGGCS-SST---EEEEEETT-TTHHHHHHHHHHHHHTT--EEEEEETTEETTG CS
  Abhydrolase_3 138 dlfwrlylp.eadrddplaspllaedlsglpptlvvvaefDplrdegeayaerlraagvevelieyegmvHgf 209
                    d++ +ly +  +++   ++   + ++++   ++l+v   ++    e++++a  l+++  +v++i  +g vHg+
     EFC39798.1 360 DIMEELYPNiPDSLVPIRFDSSVISTFK-DTKMLIVYSNHEEVTFENKQFASLLQSQHPNVTVIAEDGHVHGY 431
                    *******965555544455433333455.56899*************************************98 PP

>> Say1_Mug180  Steryl acetyl hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.0   8.9e-13     2e-09     117     343 ..     204     423 ..     182     446 .. 0.73

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 8.9e-13
  Say1_Mug180 117 fdPkvDpvllylHGGg.f...alklipvtlvfLsnlrklfpdmailvsDYtvtaakdqskk........YplqvleslavydylvkskgfknvvvlGd 202
                    P+  +vl y+HGGg f     +l+  ++v   n r  ++  +i  + Y ++  +++  k        +  q+ +++  y++l++    k++v +Gd
   EFC39798.1 204 DSPDKKKVLFYIHGGGgFgncCDGLQVSSMVEYLNGRDDHSIHTIFSVAYRLMGLDEEERKnkskfassFEEQLQDCMDAYKWLIEKYDPKDIVFMGD 301
                  468889*******976352113456667777778888888888999******976554332112222227789************************* PP

  Say1_Mug180 203 SaGGnlvLslllkl.sklnkvvlPkkaiaiSPWlnltildekekeylkasdklDvlclkglelfgklyvnnrepeeelktdefvnieknfdievWsei 299
                  S GG +v +ll k+  +l+ +  P  a+++S + ++t+ + +e   ++   +    + +  +++++ly n          d++v i   fd +v s  
   EFC39798.1 302 SFGGAVVANLLAKIgAELGIEKQPYMAVTLSGFFDTTVKSFREHFDIE---NSVIAAPNNIDIMEELYPNI--------PDSLVPIR--FDSSVIST- 385
                  *************5368888889**************66555554444...33344556777888887554........56666664..58887665. PP

  Say1_Mug180 300 lekckllityGddEilkdqikllidkiselkeksysepknvlid 343
                   +++k+li+y ++E + +++k +++ ++  +      p+  +i+
   EFC39798.1 386 FKDTKMLIVYSNHEEVTFENKQFASLLQSQH------PNVTVIA 423
                  7999999999999999999999998887333......4444444 PP

>> DUF2235  Uncharacterized alpha/beta hydrolase domain (DUF2235)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.4   0.0   2.5e-07   0.00056      67     122 ..     263     321 ..     196     359 .. 0.64

  Alignments for each domain:
  == domain 1  score: 19.4 bits;  conditional E-value: 2.5e-07
     DUF2235  67 klldgafgsgld...ehvveaYeflmrnyepgDeIylfGFSRG.AytaRalagmlekvGl 122
                 +  ++ f+s+++   +++++aY++l+++y+p D I+++G S G A +a +la++ +++G+
  EFC39798.1 263 RKNKSKFASSFEeqlQDCMDAYKWLIEKYDPKD-IVFMGDSFGgAVVANLLAKIGAELGI 321
                 3336678888872224689************65.8899***9747788888888888887 PP

>> Lipase_3  Lipase (class 3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   8.8e-06      0.02      31      90 ..     241     320 ..     222     352 .. 0.77

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 8.8e-06
                 TT-EEEHHHHHHHH................S-HHHHHHHHHHH...HHHHTT-EEEEEEEETHHHHH.HHHHHHHHHHTT CS
    Lipase_3  31 eggkvhsgfleaye................eslreqvlkelkr...llekypeysivvtGHSLGgal.AlLaaldlveng 90 
                 ++ ++h+ f  ay+                 s++eq++++++    l+eky    iv+ G S+Gga+ A L+a   +e g
  EFC39798.1 241 DDHSIHTIFSVAYRlmgldeeerknkskfaSSFEEQLQDCMDAykwLIEKYDPKDIVFMGDSFGGAVvANLLAKIGAELG 320
                 678899999999999999999999998888777788887776555588888899***********963777776666655 PP

>> Peptidase_S9  Prolyl oligopeptidase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   0.1   1.4e-05     0.032      44      83 ..     276     313 ..     271     433 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.4e-05
                   HHHHHHHHHHHHHHTTS--GGGEEEEEETHHHHHHHHHHH CS
  Peptidase_S9  44 efdDfiaaaealakegyvdserlaitGgSyGGyltgaaln 83 
                   +++D+++a ++l++++  d++ ++ +G S+GG +++ +l+
    EFC39798.1 276 QLQDCMDAYKWLIEKY--DPKDIVFMGDSFGGAVVANLLA 313
                   689*********9985..99*************9988776 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   3.2e-05     0.072      51      96 ..     269     314 ..     256     333 .. 0.90
   2 ?   -2.5   0.0       1.1   2.5e+03     192     226 ..     389     423 ..     384     430 .. 0.57

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 3.2e-05
  Hydrolase_4  51 hvpsfddyvdDlaafvekvkeehpelplfllGhSmGGliallyllr 96 
                    +sf++ ++D+  +++ + e++  + ++ +G S GG++++++l++
   EFC39798.1 269 FASSFEEQLQDCMDAYKWLIEKYDPKDIVFMGDSFGGAVVANLLAK 314
                  5689**************************************9976 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 1.1
  Hydrolase_4 192 lPllllhGeaDkvvdpeasrelyerlgsk..dktlkl 226
                  + +l++++ +++v+ ++++  ++  l+s+  ++t+  
   EFC39798.1 389 TKMLIVYSNHEEVTFENKQ--FASLLQSQhpNVTVIA 423
                  5688888888888886666..3333333300444444 PP

>> DUF3089  Protein of unknown function (DUF3089)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.0   4.4e-05     0.098      47     115 ..     247     315 ..     242     335 .. 0.84

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 4.4e-05
     DUF3089  47 rvfaPrYRqatlaal.lteeedaekaldlAyaDvaaAfeaylakenkgrPiiLaGhsQGallllrLlkee 115
                 ++f+  YR + l+    +++++ ++ ++   +D  +A+++ ++k +    i+++G s G++++ +Ll++ 
  EFC39798.1 247 TIFSVAYRLMGLDEEeRKNKSKFASSFEEQLQDCMDAYKWLIEKYDPK-DIVFMGDSFGGAVVANLLAKI 315
                 68999999999999844566666999999**********999988654.7****************9875 PP

>> UPF0227  Uncharacterised protein family (UPF0227)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0     0.014        31      39      69 ..      45      75 ..       8     107 .. 0.80
   2 ?    6.7   0.0    0.0028       6.4      39     177 ..     274     436 ..     258     445 .. 0.74

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.014
     UPF0227 39 kedpqqalkeleklvaelgddnillvGssLG 69
                ++  q+++  +e++++++++ ++ l+GssL 
  EFC39798.1 45 ENCYQYLVDLIESQLKNSSPLKLSLIGSSLS 75
                5667999999*******************96 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0028
     UPF0227  39 kedpqqalkeleklvaelgddnillvGssLGGyyatrlgerfglrq.vllnPalkplenlagklgeeavqstqetyvleeyhiielkalelsr...... 130
                 +e+ q+ +   + l++++ +++i+ +G s GG + + l ++ g +  +   P      +l+g+ +  +v+s  e++ +e+  i++ + +++ +      
  EFC39798.1 274 EEQLQDCMDAYKWLIEKYDPKDIVFMGDSFGGAVVANLLAKIGAELgIEKQPY--MAVTLSGFFDT-TVKSFREHFDIENSVIAAPNNIDIMEelypni 369
                 6778899999999*******************988887777776543445554..45678899998.88888999999999999888888888888888 PP

     UPF0227 131 ...............lkrperilvllskqDevldyrravaef....raaaeiveddg.dHafkdvse 177
                                  +  ++l++ s + ev   ++++a +    ++ ++++ +dg  H+   +  
  EFC39798.1 370 pdslvpirfdssvisTFKDTKMLIVYSNHEEVTFENKQFASLlqsqHPNVTVIAEDGhVHGYPLFHS 436
                 8888888888888776667778888888888877666665542332455666666665676655555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (454 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       645  (0.0359752); expected 358.6 (0.02)
Passed bias filter:                      537  (0.0299515); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.61u 0.28s 00:00:00.89 Elapsed: 00:00:00.45
# Mc/sec: 3004.45
//
Query:       EFC39799.1  [L=727]
Description: hypothetical protein NAEGRDRAFT_52226 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    2.7e-05   23.9   1.5    8.9e-05   22.3   1.5    1.9  1  F-box       F-box domain
     0.0039   17.0   0.6     0.0086   16.0   0.6    1.6  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.023   14.6   1.0      0.053   13.4   1.0    1.6  1  F-box_4     F-box


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.3   1.5   1.5e-08   8.9e-05       2      37 ..      17      52 ..      16      57 .. 0.93

  Alignments for each domain:
  == domain 1  score: 22.3 bits;  conditional E-value: 1.5e-08
                HHHHS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHHH CS
       F-box  2 tlsrLPsevlrhILerLplsdllalrrVSkgwrili 37
                +l++LP e l  I++++++++l++  ++Sk++r ++
  EFC39799.1 17 SLDDLPREMLFCIMSYCDPRSLVNVICCSKNLRTIT 52
                689******************************986 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.6   1.4e-06    0.0086       2      35 ..      19      52 ..      18      57 .. 0.91

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 1.4e-06
  F-box-like  2 srLPdEiLlqIFsyLppsdLlrlalVCrrWrrva 35
                ++LP E L  I sy +p++L+++ + ++  r+++
  EFC39799.1 19 DDLPREMLFCIMSYCDPRSLVNVICCSKNLRTIT 52
                78**************************999997 PP

>> F-box_4  F-box
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   1.0   8.8e-06     0.053       3      43 ..      16      56 ..      14      59 .. 0.94

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 8.8e-06
     F-box_4  3 dsLssLPlevlqhiaslLDsfsLsqLslvskllrevcssll 43
                +sL++LP e+l  i+s+ D  sL+++   sk lr ++ ++l
  EFC39799.1 16 QSLDDLPREMLFCIMSYCDPRSLVNVICCSKNLRTITMQIL 56
                689*********************************99887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (727 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       482  (0.0268838); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 4714.45
//
Query:       EFC39800.1  [L=649]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (649 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1178  (0.0657036); expected 358.6 (0.02)
Passed bias filter:                      352  (0.019633); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.64u 0.29s 00:00:00.93 Elapsed: 00:00:00.46
# Mc/sec: 4223.15
//
Query:       EFC39801.1  [L=323]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    5.3e-37  127.2   0.0    8.3e-37  126.6   0.0    1.3  1  adh_short        short chain dehydrogenase
    1.3e-17   64.1   0.0    1.7e-17   63.8   0.0    1.1  1  adh_short_C2     Enoyl-(Acyl carrier protein) reductase
    1.7e-10   41.1   0.0    2.8e-10   40.4   0.0    1.3  1  KR               KR domain
     0.0019   17.4   0.1      0.003   16.7   0.1    1.4  1  Polysacc_synt_2  Polysaccharide biosynthesis protein


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  126.6   0.0   1.8e-40   8.3e-37       2     187 ..      43     243 ..      42     251 .. 0.92

  Alignments for each domain:
  == domain 1  score: 126.6 bits;  conditional E-value: 1.8e-40
                 EEEEESTTSHHHHHHHHHHHHTT..-EEEEEESCHHHHHHHHHHHHHT....TSEEEEEE-TTTSHHHHHHHHHHHHHHH.SSESEEEE---SS--SSG CS
   adh_short   2 vvlvtGassGIGraiakelakeG..akvvvvdrseekleevakelkee....gakalaiqvDvtdreevealvekavkkl.gkldvLvnNAGitgsgpf 93 
                 ++++tGassGIG ++ +++ + G   k+v+++r+ ekl+e+++ + +e    g +++++++Dv+  ee+++l+e  +k l +++dv++ NAG + +++f
  EFC39801.1  43 HIIITGASSGIGEQLLRHYCTIGkrNKIVITARNVEKLQELKEIMLKEysgkGHEIFCVKTDVSVDEECKNLIELSAKYLnERIDVIYLNAGRSAVQMF 141
                 79*****************99883356888**********988766666766889*******************99998899***************** PP

                 GGCSHHH.HHHHHHHHTHHHHHHHHHHHHHHH..HCTTEEEEEEEEGGGTSB-TTBHHHHHHHHHHHHHHHHHHHHHGGGT.....EEEEEEEESSBSS CS
   adh_short  94 selseee.wervievNltgvflltravlpaml..kqssGrIvnvsSvagkvpvagvaaYsAsKaavagltrslakelaptg.....irvnavaPGlvdT 184
                 ++ ++ +  ++++e+N++g +  t  +++++   ++s  +I  vsS ag+ +v   +aYs+sK+a++g+ ++l+ el ++g     +++++v+PG+v+T
  EFC39801.1 142 AQATNLDgHRSLMETNFFGCVTPTFYLMKHLRekQESHCSICVVSSLAGLSGVCYRTAYSSSKFALHGFYEALKLELLKEGiygkkVTISIVCPGFVKT 240
                 **999999**********************997677889***************************************99988899************* PP

                 HHH CS
   adh_short 185 dma 187
                 ++ 
  EFC39801.1 241 QIH 243
                 986 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.8   0.0   3.8e-21   1.7e-17       1     188 [.      48     252 ..      48     276 .. 0.77

  Alignments for each domain:
  == domain 1  score: 63.8 bits;  conditional E-value: 3.8e-21
                   TTTTSHHHHHHHHHHHTT-E..EEEEESSGGH.HHHHHHHHHHTTSE...E..EE--TTSHHHHHHHHHHHHHHH.SSEEEEEE-----EGCSS-GG CS
  adh_short_C2   1 GaasgIGraiAkalaeeGae..vvltdlneea.kkrveelaeelgae...v..lecDVtdeeqvealveevvekf.gklDilvnnagiapklkgpfl 88 
                   Ga sgIG+++ +++   G +  +v+t +n e+ ++  e + +e++ +   +  +++DV+ +e++++l+e  ++ + +++D++  nag +   +  + 
    EFC39801.1  48 GASSGIGEQLLRHYCTIGKRnkIVITARNVEKlQELKEIMLKEYSGKgheIfcVKTDVSVDEECKNLIELSAKYLnERIDVIYLNAGRSAV-QMFAQ 143
                   899*************997555*********9555555556666633334469****************99999999*************9.45555 PP

                   GH-HHHHHHHHHHHTHHH....HHHHHHHHHHCTSCCEEEEEEEGGGTSBSTTTTHHHHHHHHHHHHHHHHHHHHGGGTE.....EEEEEEE--BHC CS
  adh_short_C2  89 etsreefdraldvnlysl....fllakaalplmkeggsivnlssvgaervvpnynaygaaKaalealtrylAvelgpkgi.....RvNavspgpikT 176
                    t+ ++ +  +++n+ ++    f+l+k++++  +++ si  +ss+++  +v   +ay+ +K al+++  +l  el ++gi     ++  v+pg++kT
    EFC39801.1 144 ATNLDGHRSLMETNFFGCvtptFYLMKHLREKQESHCSICVVSSLAGLSGVCYRTAYSSSKFALHGFYEALKLELLKEGIygkkvTISIVCPGFVKT 240
                   5899***********9971111455555555555559**************************************997654443399********** PP

                   TGGGGSTTHHHH CS
  adh_short_C2 177 laasgikgfdel 188
                   ++  ++ g+++ 
    EFC39801.1 241 QIHFNALGTENK 252
                   996555443332 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.4   0.0   6.3e-14   2.8e-10       4     161 ..      45     212 ..      43     225 .. 0.83

  Alignments for each domain:
  == domain 1  score: 40.4 bits;  conditional E-value: 6.3e-14
                 EEETTTSHHHHHHHHHHHHHH.S-EEEEE-SS...--HHHHHHHHHHHHTT-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE---------TTT CS
          KR   4 litGGlGgLGlelarwlaekg.arhlvllsRsa.aadedskaliaelealgaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvlrdkllee 99 
                 +itG+  g+G +l r+ +  g ++++v+++R+  + +e ++ +++e + +g e+ +v+ Dvs  ++ ++l+e   +   ++i  ++  Ag ++ +++++
  EFC39801.1  45 IITGASSGIGEQLLRHYCTIGkRNKIVITARNVeKLQELKEIMLKEYSGKGHEIFCVKTDVSVDEECKNLIELSAKYLnERIDVIYLNAGRSAVQMFAQ 143
                 8********************7778*******734455566699****************************99887789*****************99 PP

                 --HHH.....HHHHHTTTTHHHHHHHHHTTT..S--SEEEEEEEHHHHH--TT-HHHHHHHHHHHHHHH CS
          KR 100 mtaed.....leqvlapKvkGawnLhelled..esldffvlfSSiagllgsagqanYaaaNaflDalae 161
                  t+ d     +e+ +   v+ +  L + l++  es   + ++SS+agl g   +++Y++    l+++ e
  EFC39801.1 144 ATNLDghrslMETNFFGCVTPTFYLMKHLREkqESHCSICVVSSLAGLSGVCYRTAYSSSKFALHGFYE 212
                 987552111144445566788889999998854455567889****************99888887766 PP

>> Polysacc_synt_2  Polysaccharide biosynthesis protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.7   0.1   6.8e-07     0.003       1      74 [.      44     116 ..      44     160 .. 0.83

  Alignments for each domain:
  == domain 1  score: 16.7 bits;  conditional E-value: 6.8e-07
                      EEEETTTSHHHHHHHHHHHHH.B-SEEEEEES-HHHHHHHHHH......-TTEEEE....E--TT-HHHHHHHTT CS
  Polysacc_synt_2   1 vlvtGagGsiGselvrqilkk.kpkkiillerdElklyeiekeleeelkkkklkveivpvigdvrdkerlekale 74 
                      +++tGa+  iG++l+r+ ++  k +ki++  r+  kl+e+++ + +e++ k  +++  +v +dv   e++++++e
       EFC39801.1  44 IIITGASSGIGEQLLRHYCTIgKRNKIVITARNVEKLQELKEIMLKEYSGKGHEIF--CVKTDVSVDEECKNLIE 116
                      79****************9998999******************9999999877555..77778887777777766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (323 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       808  (0.0450667); expected 358.6 (0.02)
Passed bias filter:                      637  (0.035529); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.59u 0.28s 00:00:00.87 Elapsed: 00:00:00.47
# Mc/sec: 2075.75
//
Query:       EFC39802.1  [L=140]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (140 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       448  (0.0249875); expected 358.6 (0.02)
Passed bias filter:                      288  (0.0160634); expected 358.6 (0.02)
Passed Vit filter:                        13  (0.000725082); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.45
# Mc/sec: 935.32
//
Query:       EFC39803.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.3e-09   36.9   1.2    1.1e-05   24.6   0.1    3.9  4  EF-hand_1      EF hand
    6.3e-09   36.2   5.1    9.7e-09   35.6   1.7    2.2  2  EF-hand_7      EF-hand domain pair
    2.4e-08   33.2  10.2    7.2e-06   25.5   0.2    4.1  4  EF-hand_6      EF-hand domain
    1.9e-05   23.9   7.3     0.0031   16.9   0.0    3.2  3  EF-hand_5      EF hand
  ------ inclusion threshold ------
      0.019   14.8   2.7      0.019   14.8   2.7    2.8  3  EF-hand_8      EF-hand domain pair
       0.13   12.6   0.2        2.2    8.7   0.2    2.3  1  SPARC_Ca_bdg   Secreted protein acidic and rich in cysteine C
       0.14   12.2   0.0       0.49   10.4   0.0    1.7  2  Grp7_allergen  Group 7 allergen


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   1.7       2.2   5.7e+03       1      10 [.      42      51 ..      42      52 .. 0.84
   2 !   24.6   0.1   4.4e-09   1.1e-05       2      28 ..      98     124 ..      97     125 .. 0.93
   3 ?    0.3   0.3      0.25   6.3e+02      11      24 ..     131     144 ..     131     146 .. 0.84
   4 !   18.0   0.1   5.5e-07    0.0014       2      22 ..     146     166 ..     145     168 .. 0.93

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.2
                HHHHHHHHHT CS
   EF-hand_1  1 elkeiFrefD 10
                e++ +Fr fD
  EFC39803.1 42 EFDLFFRFFD 51
                6888999999 PP

  == domain 2  score: 24.6 bits;  conditional E-value: 4.4e-09
                 HHHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEfkellkk 28 
                 l+ iF+ +D Dg+G I+++E+++++++
  EFC39803.1  98 LRYIFEYYDGDGSGVIERDELLSFMQD 124
                 688**********************85 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.25
                 TTSSSEEEHHHHHH CS
   EF-hand_1  11 kDgdGkIdfeEfke 24 
                 k+gd  I+ e+  +
  EFC39803.1 131 KNGDEDISEEDISD 144
                 79*******99766 PP

  == domain 4  score: 18.0 bits;  conditional E-value: 5.5e-07
                 HHHHHHHHTTTSSSEEEHHHH CS
   EF-hand_1   2 lkeiFrefDkDgdGkIdfeEf 22 
                 ++e+  + D+DgdG I++ E 
  EFC39803.1 146 VDEMLHDCDVDGDGNISYHEI 166
                 79*****************96 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.1      0.15   3.8e+02      27      60 ..      30      57 ..      21      76 .. 0.68
   2 !   35.6   1.7   3.8e-12   9.7e-09       4      66 ..      98     166 ..      95     169 .. 0.83

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.15
   EF-hand_7 27 llrkifqgagegsklsdeelellfkefDtdkdGv 60
                +l++      +  +  ++e +l+f+ fD +  G 
  EFC39803.1 30 FLEN-----LTSRE-LKKEFDLFFRFFDYRPTGN 57
                5554.....33333.4467888888888766664 PP

  == domain 2  score: 35.6 bits;  conditional E-value: 3.8e-12
   EF-hand_7   4 lkeaFkelDtdgdgyldkeellrllrkifqga..gegsklsdeelellfkef....DtdkdGvisfdEF 66 
                 l+++F+ +D dg+g ++++ell++++   ++     ++++s+e + +l++e+    D d+dG is+ E 
  EFC39803.1  98 LRYIFEYYDGDGSGVIERDELLSFMQDVQEALskNGDEDISEEDISDLVDEMlhdcDVDGDGNISYHEI 166
                 7899*******************999887777887777777777666666666666**********996 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.6      0.21   5.3e+02       2      16 ..      43      57 ..      42      61 .. 0.79
   2 !   25.5   0.2   2.8e-09   7.2e-06       2      28 ..      98     124 ..      97     134 .. 0.90
   3 ?    0.1   0.1       0.4     1e+03       9      24 ..     129     144 ..     127     151 .. 0.80
   4 !   10.4   0.1   0.00021      0.53       8      23 ..     152     167 ..     145     173 .. 0.82

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.21
   EF-hand_6  2 lreaFklfDkdgdGk 16
                ++ +F+ fD+  +G 
  EFC39803.1 43 FDLFFRFFDYRPTGN 57
                6679*****988885 PP

  == domain 2  score: 25.5 bits;  conditional E-value: 2.8e-09
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrkalrk 28 
                 lr++F+++D dg+G i ++El +++++
  EFC39803.1  98 LRYIFEYYDGDGSGVIERDELLSFMQD 124
                 89**********************995 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.4
   EF-hand_6   9 fDkdgdGkidaeElrk 24 
                 + k+gd  i+ e++ +
  EFC39803.1 129 LSKNGDEDISEEDISD 144
                 5689999999999866 PP

  == domain 4  score: 10.4 bits;  conditional E-value: 0.00021
   EF-hand_6   8 lfDkdgdGkidaeElr 23 
                   D+dgdG i+++E+ 
  EFC39803.1 152 DCDVDGDGNISYHEIL 167
                 67************97 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   1.4       2.2   5.8e+03       4       9 ..      46      51 ..      42      52 .. 0.78
   2 !   16.9   0.0   1.2e-06    0.0031       5      25 .]     102     122 ..      98     122 .. 0.92
   3 !   10.4   0.1   0.00014      0.35       9      20 ..     154     165 ..     145     167 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 2.2
                HHHHH- CS
   EF-hand_5  4 tFqaiD 9 
                +F+ +D
  EFC39803.1 46 FFRFFD 51
                799999 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 1.2e-06
                 HHHH-SS-SSCE-HHHHHHHH CS
   EF-hand_5   5 FqaiDlNgDGkIskeELktlv 25 
                 F+  D +g+G I ++EL  ++
  EFC39803.1 102 FEYYDGDGSGVIERDELLSFM 122
                 999**************9886 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.00014
                 -SS-SSCE-HHH CS
   EF-hand_5   9 DlNgDGkIskeE 20 
                 D++gDG Is  E
  EFC39803.1 154 DVDGDGNISYHE 165
                 9********998 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.3       3.9     1e+04      26      36 ..      41      51 ..      40      51 .. 0.71
   2 ?    9.3   0.1   0.00039         1      28      54 ..      98     124 ..      86     125 .. 0.85
   3 ?   14.8   2.7   7.5e-06     0.019       2      48 ..     110     166 ..     109     169 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 3.9
   EF-hand_8 26 eevdilfrefD 36
                +e+d  fr fD
  EFC39803.1 41 KEFDLFFRFFD 51
                67777788887 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00039
   EF-hand_8  28 vdilfrefDtdgdGkisfeEFcvller 54 
                 ++ +f + D dg+G+i  +E + ++++
  EFC39803.1  98 LRYIFEYYDGDGSGVIERDELLSFMQD 124
                 57899999****************986 PP

  == domain 3  score: 14.8 bits;  conditional E-value: 7.5e-06
   EF-hand_8   2 kgkItreelrrilrilglkk.......glseeevdilfref....DtdgdGkisfeEF 48 
                 +g+I r+el +++  ++ +        ++see++ +l++e+    D dgdG is+ E 
  EFC39803.1 110 SGVIERDELLSFMQDVQ-EAlskngdeDISEEDISDLVDEMlhdcDVDGDGNISYHEI 166
                 79***********7762.22455778**************99999*********9886 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7   0.2   0.00084       2.2      88     109 ..     144     165 ..      53     168 .. 0.61

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00084
  SPARC_Ca_bdg  88 hCikpflescDadkdkkislkE 109
                     ++++l+ cD+d d++is +E
    EFC39803.1 144 DLVDEMLHDCDVDGDGNISYHE 165
                   345788999******9999988 PP

>> Grp7_allergen  Group 7 allergen
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   0.00019      0.49      67     151 ..      24     104 ..      20     106 .. 0.88
   2 ?   -1.0   0.0      0.62   1.6e+03     148     180 .]     118     150 ..     109     150 .. 0.76

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00019
  Grp7_allergen  67 desvleveadvgiralaftykisvkfldlGPtasvavdvayirflleaiididgivvlkdFkLkelgnlklkltGlglldwlaei 151
                    + + ++++ +   r+l+ ++++  +f+d  Pt+++  d+   +++++ + d d++     F+ ke+ +l+ kl+   ll +++e+
     EFC39803.1  24 STEQIQFLENLTSRELKKEFDLFFRFFDYRPTGNLLRDI---NLFMKILADEDFETPSPIFDSKEVSKLQKKLQS-RLLRYIFEY 104
                    566788888999999999*****************8876...7889999***********************986.578899887 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 0.62
  Grp7_allergen 148 laeifvdvitkllknkvkevvesriadliaakL 180
                    l  ++ dv   l kn  +++ e+ i+dl++ +L
     EFC39803.1 118 LLSFMQDVQEALSKNGDEDISEEDISDLVDEML 150
                    666777888888899999999999999998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       714  (0.0398237); expected 358.6 (0.02)
Passed bias filter:                      577  (0.0321825); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.40u 0.26s 00:00:00.66 Elapsed: 00:00:00.38
# Mc/sec: 1409.49
//
Query:       EFC39804.1  [L=1885]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0028   17.8   0.3      0.021   15.0   0.0    2.6  2  DUF3467          Protein of unknown function (DUF3467)
  ------ inclusion threshold ------
      0.011   16.1   1.3      0.011   16.1   1.3    5.3  6  RNA_pol_Rpb4     RNA polymerase Rpb4
      0.064   13.4   0.0       0.63   10.3   0.0    2.9  2  TPR_2            Tetratricopeptide repeat
      0.074   12.9   0.2       0.35   10.7   0.0    2.2  2  Methyltransf_14  C-methyltransferase C-terminal domain
       0.12   12.6   1.1        5.3    7.3   0.0    3.3  3  DUF1858          Domain of unknown function (DUF1858)
       0.52   10.6   5.5        2.9    8.2   0.0    4.7  6  YnfE             Uncharacterized YnfE-like


Domain annotation for each model (and alignments):
>> DUF3467  Protein of unknown function (DUF3467)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1       1.6   4.9e+03      42      79 ..     578     613 ..     565     617 .. 0.76
   2 !   15.0   0.0   7.1e-06     0.021      33      88 ..    1527    1594 ..    1490    1615 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1.6
     DUF3467  42 iidFlqlv.pgrpearvksrvvlspaaakqlvaaLqknl 79 
                 +++Fl++  + ++++   +r v    + +++v++L++ l
  EFC39804.1 578 MLVFLKTAtELLQQSSKDERMVF---RIERFVKILDEAL 613
                 57888888788888888888775...6778888888876 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 7.1e-06
     DUF3467   33 ivmt.spsEfiidF...........lqlvpgrpearvksrvvlspaaakqlvaaLqknldlyetrfGe 88  
                  ++++ + s+++i F           l l++++++    + v++++ +   l++ Lq+++++y t+f++
  EFC39804.1 1527 YIKHfGSSDIYISFlvrngkldaaiLYLFKKQMSQSLFVDVIVTYCVKYGLMKFLQNVIKQYDTTFTK 1594
                  56777999******877777666666699999999*******************************95 PP

>> RNA_pol_Rpb4  RNA polymerase Rpb4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1       2.4   7.1e+03      43      78 ..     105     140 ..     100     143 .. 0.72
   2 ?    2.4   0.8     0.063   1.9e+02      27      92 ..     219     293 ..     178     304 .. 0.71
   3 ?   -2.8   0.1       2.6   7.7e+03      70      92 ..     431     457 ..     401     482 .. 0.63
   4 ?   -3.4   0.0       3.8   1.1e+04      31      57 ..    1445    1471 ..    1434    1520 .. 0.48
   5 ?   -1.7   0.2       1.1   3.4e+03      39      68 ..    1586    1615 ..    1578    1649 .. 0.70
   6 ?   16.1   1.3   3.6e-06     0.011      40     106 ..    1780    1854 ..    1757    1870 .. 0.78

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 2.4
                   HHHHHHHHHHHCTHHTTSSHHH.HHHHHHHHTTSTST CS
  RNA_pol_Rpb4  43 kilkktleyltnkfsrlkneek.fnelvellksfeLt 78 
                   k+l + ++y+   f  l ++++  ++++++l+s++Lt
    EFC39804.1 105 KELVRHMKYIYS-FRLLSKKKStTETVITTLSSTGLT 140
                   555566788887.666655444499999***999987 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.063
                   C........CCCCHHSHCHTCHHCHHHHHHHHHHHCTHHTTSSHHH..HHHHHHHHTTSTSTHHHHHHHHHCSTSS CS
  RNA_pol_Rpb4  27 e........ddkisekeevkgnlnkilkktleyltnkfsrlkneek..fnelvellksfeLtkaEklqlvnlkPes 92 
                   +        ++ i+ k++ +++l  i++++l   +    + ++ e+   + +++ l +  L k  ++ ++   P+s
    EFC39804.1 219 KnifkqlieNKAIALKSRPNNQLIDIIYESLFIADI-SDKEYSDEQfkLTRIFTSLDEELLSKQKLIDIIQASPSS 293
                   044433432444888999999999999999887776.55555555533788999999999***********99987 PP

  == domain 3  score: -2.8 bits;  conditional E-value: 2.6
                   HHHTTST...STHHHHHHH.HHCSTSS CS
  RNA_pol_Rpb4  70 ellksfe...LtkaEklql.vnlkPes 92 
                   ++l + +    +k+E+++l ++l+P++
    EFC39804.1 431 KKLAENDfkfTNKKEIANLlIDLAPSQ 457
                   333332244567888887536777765 PP

  == domain 4  score: -3.4 bits;  conditional E-value: 3.8
                    CHHSHCHTCHHCHHHHHHHHHHHCTHH CS
  RNA_pol_Rpb4   31 isekeevkgnlnkilkktleyltnkfs 57  
                    ++ ++ ++++ ++ l++ l  l+ ++s
    EFC39804.1 1445 KYCLTLTPQQKQQLLNRILAILEGAPS 1471
                    455555566666666666655555333 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 1.1
                    CHHCHHHHHHHHHHHCTHHTTSSHHH.HHHH CS
  RNA_pol_Rpb4   39 gnlnkilkktleyltnkfsrlkneek.fnel 68  
                    ++ ++ + k++ ylt   +++ n+++  n l
    EFC39804.1 1586 KQYDTTFTKCYPYLTA-TCKYLNQKQaLNLL 1615
                    667889999999***9.66665555533333 PP

  == domain 6  score: 16.1 bits;  conditional E-value: 3.6e-06
                    HHCHHHHHHHH.HHHCTHHTTSSHHH.HHHHHHHHTTST....STHHHHHHHHHCSTSSHHHHHHHSTTGTT...T CS
  RNA_pol_Rpb4   40 nlnkilkktle.yltnkfsrlkneek.fnelvellksfe....LtkaEklqlvnlkPesavelktlieelee...r 106 
                    + + i+++ ++ y+++  +  kn+ek +++l++  k+       +++ ++ l+  k+++++++k++++++++   +
    EFC39804.1 1780 DWDAIINNIIKlYIKE-MNDEKNAEKfIAKLRNDSKKVRacllCNRFKAAYLIAVKCDNLDDVKLIFDYCNQvdsK 1854
                    5678999999989998.777777777666677777766699866**************************963333 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.0       4.8   1.4e+04      13      28 ..     939     954 ..     936     956 .. 0.74
   2 ?   10.3   0.0   0.00021      0.63       3      33 ..    1423    1453 ..    1422    1454 .. 0.93

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 4.8
       TPR_2  13 klgdyeeAleafekAl 28 
                  ++dy+ Ale  ek l
  EFC39804.1 939 DADDYNLALEMAEKGL 954
                 6778888888888766 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 0.00021
       TPR_2    3 alynlGlayyklgdyeeAleafekAleldPn 33  
                  ++ ++G  ++ lg+y++A++ ++ +l l P+
  EFC39804.1 1423 IWTQWGITLLTLGKYKQARDKLKYCLTLTPQ 1453
                  58899***********************996 PP

>> Methyltransf_14  C-methyltransferase C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.0       1.4   4.1e+03     118     147 ..     336     365 ..     331     368 .. 0.70
   2 ?   10.7   0.0   0.00012      0.35      21      87 ..     481     548 ..     476     566 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.4
  Methyltransf_14 118 speklkeekpdyvlilaW.nlkeeileqlae 147
                      ++e++++++p ++++l+W n+k  i+e+++ 
       EFC39804.1 336 DQENFSNMRP-LIILLSWdNYKSDITERHNI 365
                      4555566655.66778886899999999875 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00012
  Methyltransf_14  21 vseavaellaeEkaagldeletyaeFaervekvkeellalllelkaegkkvvgYGAaa.kgntllnyc 87 
                      ++++++e  ++E++  l+ l+ y +++e+++ v+++ +++l++lk+ + ++v  ++ + + +tl n +
       EFC39804.1 481 KRPQLRETTENERNIDLTLLRAYFAIHEAIQIVRNKSTSILDSLKSIEDSIVNISSESyRLSTLENIF 548
                      578999********************************************998876431445665555 PP

>> DUF1858  Domain of unknown function (DUF1858)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.1       1.7   5.2e+03       6      46 ..     152     187 ..     151     190 .. 0.80
   2 ?    7.3   0.0    0.0018       5.3       3      21 ..     694     715 ..     693     722 .. 0.81
   3 ?    2.1   0.0     0.074   2.2e+02       6      30 ..    1225    1251 ..    1219    1254 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 1.7
                 BHHHHHHH-GGGHHHHHHTTGGGGGSCCHHTTHHHHSBHHH CS
     DUF1858   6 tIgelleeyPelaevLvelGfhclgcpsllktvakvetleq 46 
                  Ige+ e+ P la +L ++ f+ ++ +s       +e+le 
  EFC39804.1 152 LIGEMYEKCPFLAFYLERNAFEFINGKS-----ILIEKLEN 187
                 69***********999999998887777.....66666665 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0018
                 TTSBHHHHHHH-GGGH...HHH CS
     DUF1858   3 kdttIgelleeyPela...evL 21 
                 kd+++ge+++++P+++   +vL
  EFC39804.1 694 KDKSVGEIIQKFPNFItlfDVL 715
                 9**************9555555 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.074
                  BHHHHHHH-GGGH..HHHHHTTGGGGG CS
     DUF1858    6 tIgelleeyPela..evLvelGfhclg 30  
                  ++  +l e Pel   ++L+e+G++ l+
  EFC39804.1 1225 KVSRILNELPELQndDLLIEYGMKALS 1251
                  6889999******999*******9885 PP

>> YnfE  Uncharacterized YnfE-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.66     2e+03      51      78 .]     522     549 ..     510     549 .. 0.83
   2 ?   -0.9   0.0      0.71   2.1e+03       1      17 [.     775     791 ..     775     800 .. 0.86
   3 ?   -2.1   0.0       1.6   4.9e+03      32      43 ..    1175    1186 ..    1173    1188 .. 0.84
   4 ?   -2.5   0.0       2.1   6.3e+03      62      75 ..    1376    1389 ..    1373    1390 .. 0.89
   5 ?   -1.2   0.0      0.84   2.5e+03      21      53 ..    1661    1696 ..    1649    1701 .. 0.71
   6 ?    8.2   0.0   0.00099       2.9      32      69 ..    1760    1797 ..    1756    1805 .. 0.81

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.66
        YnfE  51 edfDevvdavvkcAagDlsleeLeevyr 78 
                 ++   + d++v++ ++   l+ Le++++
  EFC39804.1 522 DSLKSIEDSIVNISSESYRLSTLENIFQ 549
                 6677899******************996 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.71
        YnfE   1 eiLrqYvelvkknieti 17 
                 eiLr+Y+e+ k ++  +
  EFC39804.1 775 EILRKYIEVEKTKSTSL 791
                 89*******99987665 PP

  == domain 3  score: -2.1 bits;  conditional E-value: 1.6
        YnfE   32 qkeqlelYekqL 43  
                  +k+qle+Y   L
  EFC39804.1 1175 KKDQLEQYTASL 1186
                  79******8776 PP

  == domain 4  score: -2.5 bits;  conditional E-value: 2.1
        YnfE   62 kcAagDlsleeLee 75  
                  +cA g +sl++L +
  EFC39804.1 1376 NCAIGSISLSDLSQ 1389
                  6**********975 PP

  == domain 5  score: -1.2 bits;  conditional E-value: 0.84
        YnfE   21 DYeGkeeDlekq...keqlelYekqLkqesssdedf 53  
                       e+D++kq    +++ +Y k+++ +    ++f
  EFC39804.1 1661 QNSSTENDVQKQvlkPDEISRYVKTINLQTEVTKKF 1696
                  556679999998443599999999987666665555 PP

  == domain 6  score: 8.2 bits;  conditional E-value: 0.00099
        YnfE   32 qkeqlelYekqLkqesssdedfDevvdavvkcAagDls 69  
                  q   +e+  kq++   +sded+D +++ ++k   +++ 
  EFC39804.1 1760 QIAIIENLLKQIRGTPISDEDWDAIINNIIKLYIKEMN 1797
                  4445788888999999***************9888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1885 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1079  (0.0601818); expected 358.6 (0.02)
Passed bias filter:                      388  (0.0216409); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.99u 0.31s 00:00:01.30 Elapsed: 00:00:00.49
# Mc/sec: 11569.62
//
Query:       EFC39805.1  [L=1341]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-10   41.3  14.2    3.2e-10   40.2  14.2    1.5  1  TM2       TM2 domain
    4.5e-07   29.9   0.1    1.5e-06   28.3   0.1    2.0  1  PPR_2     PPR repeat family
    0.00019   21.5   0.1     0.0013   18.8   0.0    2.5  2  PPR_3     Pentatricopeptide repeat domain
     0.0011   18.9  13.0     0.0011   18.9  13.0    6.1  6  LMP       LMP repeated region
  ------ inclusion threshold ------
        0.2   12.0   0.8        3.9    7.9   0.1    3.3  3  PPR       PPR repeat
        9.9    6.8  11.6        2.2    8.8   6.0    3.0  3  KI67R     KI67R (NUC007) repeat


Domain annotation for each model (and alignments):
>> TM2  TM2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.2  14.2   1.1e-13   3.2e-10       7      50 ..     291     333 ..     286     334 .. 0.94

  Alignments for each domain:
  == domain 1  score: 40.2 bits;  conditional E-value: 1.1e-13
         TM2   7 vaylLwffLGglGvHRFYlGktgsGvlqlltfvGglgiwwlidl 50 
                 +a+ L++f+G++G++RFYlG++g G+++++tf Gg+g+ w++d+
  EFC39805.1 291 TALGLSIFFGFCGFDRFYLGYVGYGLFKMFTF-GGIGLLWIYDV 333
                 7999****************************.*********97 PP

>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.1   5.1e-10   1.5e-06       5      46 ..      60     101 ..      57     103 .. 0.95

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 5.1e-10
       PPR_2   5 tyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilik 46 
                  yN +I  ++++ ++++A  +f+eM+  ++ P++ T+s+li 
  EFC39805.1  60 HYNEIIWKCVENAQSDKAKYMFDEMRAENIVPDVETFSMLIG 101
                 5***************************************95 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   4.3e-07    0.0013      13      58 ..      56     101 ..      47     103 .. 0.91
   2 ?   -2.4   0.0       1.8   5.4e+03      26      44 ..     538     556 ..     535     557 .. 0.82

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 4.3e-07
       PPR_3  13 ldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailg 58 
                 + v  Y+ ++  ++ +   + a + +++m+ + i P v t+++++g
  EFC39805.1  56 ITVDHYNEIIWKCVENAQSDKAKYMFDEMRAENIVPDVETFSMLIG 101
                 55778***************************************98 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.8
       PPR_3  26 anagnkklalevlermkkk 44 
                 ++++n +  +++l +m +k
  EFC39805.1 538 VKTQNDETTNQILHEMIEK 556
                 5788999999****99776 PP

>> LMP  LMP repeated region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   4.4      0.36   1.1e+03      12      78 ..     373     437 ..     364     447 .. 0.65
   2 !   18.9  13.0   3.6e-07    0.0011      16     137 ..     450     570 ..     440     585 .. 0.86
   3 ?   -4.0   3.6         4   1.2e+04      64      89 ..     648     661 ..     588     702 .. 0.53
   4 ?   -2.6   2.3       1.6   4.7e+03      59     114 ..     775     831 ..     729     837 .. 0.57
   5 ?   -1.3   0.1      0.63   1.9e+03      68     101 ..     901     937 ..     884     938 .. 0.79
   6 ?    1.2  10.0      0.11   3.2e+02      12      87 ..    1072    1145 ..    1054    1177 .. 0.72

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 0.36
         LMP  12 nDkeiqkakkeLekeiqkanqalnsnn..tasmqsakssLdakvteitkkLekFnkdkeakFkeLeqtR 78 
                 + ++i +  + L   +++ n+++ns     +s+ s+ s L   + e    Lek +++ke+k ++L q R
  EFC39805.1 373 KREKIRHNLDALTMSMRSGNNSVNSSVdlSDSFSSISSRLSINLNE---MLEK-QQNKEKKLEQLAQKR 437
                 5566666667777778888888865421134555555555554444...4444.789999999999987 PP

  == domain 2  score: 18.9 bits;  conditional E-value: 3.6e-07
         LMP  16 iqkakkeLekeiqka.nqalnsnntasmqsakssLdakvteitkkLekFnkdkeakFkeLeqtRkdieeFlkdvknnpnYaelvkdLtskkdsknsvtk 113
                 i +   e  k++q a nq++  + +a+m+++k+  ++k+ +++ +Le+ + dke   ++++  R++++  ++d  n  +  +l+++  s ++++n  t+
  EFC39805.1 450 IEQRLIEYRKQLQIAiNQKI--QLEAEMENLKQNFEDKLVNYELQLEELKLDKEMAEEHVNSYREQLDGIVNDLANAGYTGDLIQNYSSTVKTQNDETT 546
                 55555555666665524555..45799************************************************************************ PP

         LMP 114 ssnkseieaaneeLkqaLakakaa 137
                      e+++ n++L + +++ + +
  EFC39805.1 547 NQILHEMIEKNKDLSKIINDLESK 570
                 ****************99886654 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 4
         LMP  64 nkdkeakFkeLeqtRkdieeFlkdvk 89 
                  kdke k + L+            +k
  EFC39805.1 648 SKDKESKSNSLQ------------IK 661
                 233333333333............22 PP

  == domain 4  score: -2.6 bits;  conditional E-value: 1.6
         LMP  59 kLekFnkdke..akFkeLeqtRkdieeFlkdvknnpnYaelvk..dLtskkdsknsvtks 114
                 +Le F+k     ++Fke+e+  kd+ e  ++ +  + + e++k  dLt++ ++ n vt+s
  EFC39805.1 775 ILESFRKRYSyiTNFKEMENVVKDVMEL-DN-VA-DRFLEVLKrdDLTEDFSNENTVTIS 831
                 3455555433224666666666666653.22.22.3344444333577777777777766 PP

  == domain 5  score: -1.3 bits;  conditional E-value: 0.63
         LMP  68 eakFkeLeqtRkdieeFl...kdvknnpnYaelvkdL 101
                 +a+F+ L+q  + i++ l    +++ n+++ +l ++L
  EFC39805.1 901 QAEFESLNQNCRIIQKLLtetPQIVCNEKFHNLCEQL 937
                 689************9996323577788888888776 PP

  == domain 6  score: 1.2 bits;  conditional E-value: 0.11
         LMP   12 nDkeiqkakkeLekeiqkanqalnsnntasmq.sakssLdakvteitkkLekFnkdkeakFkeLeqtRkdieeFlkd 87  
                  +D  i +  +   ++++k nq+l++   ++++  +++ L++k  e++k L + n dk+ +Fk+L q  +d+e F ++
  EFC39805.1 1072 KDLSIYENMRPSMEKVEKENQSLKR-TLEEIElKLRKTLEQK-DELEKSLAESN-DKDEEFKKLTQKLRDLEGFREK 1145
                  5556665555556678888888844.4555543678888888.78999998865.9***************999754 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.9   0.1    0.0013       3.9       3      31 .]      61      89 ..      59      89 .. 0.90
   2 ?    0.8   0.0      0.26   7.6e+02       6      31 .]      99     124 ..      94     124 .. 0.72
   3 ?   -3.4   0.0       5.5   1.7e+04      22      30 ..     549     557 ..     548     557 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0013
         PPR  3 ynslIsgycknGkleeAlelfkeMkekGi 31
                yn +I  ++ n + ++A+ +f+eM+ ++i
  EFC39805.1 61 YNEIIWKCVENAQSDKAKYMFDEMRAENI 89
                888999999999************98875 PP

  == domain 2  score: 0.8 bits;  conditional E-value: 0.26
         PPR   6 lIsgycknGkleeAlelfkeMkekGi 31 
                 lI +     ++  A+ +++eM+  G+
  EFC39805.1  99 LIGSTLFDANPLRAVNYLEEMIHLGV 124
                 55555555577889*******99986 PP

  == domain 3  score: -3.4 bits;  conditional E-value: 5.5
         PPR  22 lfkeMkekG 30 
                 +++eM+ek+
  EFC39805.1 549 ILHEMIEKN 557
                 799***985 PP

>> KI67R  KI67R (NUC007) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.5   0.1       5.2   1.6e+04      60      88 ..     142     170 ..     136     181 .. 0.68
   2 ?    8.8   6.0   0.00074       2.2      14     108 ..    1049    1145 ..    1041    1148 .. 0.83
   3 ?   -2.4   0.0       2.4   7.1e+03       2      38 ..    1184    1219 ..    1183    1229 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.5 bits;  conditional E-value: 5.2
       KI67R  60 gddkdiklfketpkqkldpaenvtgskRr 88 
                 + ++  klfke + ++  + e+v    R 
  EFC39805.1 142 KHNNTSKLFKEFSGKQTVTNEEVLAAVRS 170
                 55667788888777666666666555554 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00074
       KI67R   14 pvntptsrkrqlktslqk.vdveeelsalrkptqtpgetththkepegddkdikl.fketpkqkldpaenvtgskRrprtpKekaqslEDlagfkEL 108 
                   +  p++r+    t  ++ + v+++ls  ++   + ++  + ++  +   ++i+l +++t +qk + ++++++s  + +  K+ +q l Dl gf+E 
  EFC39805.1 1049 MIMNPKNRESLKDTFEERlISVKKDLSIYENMRPSMEKVEKENQSLKRTLEEIELkLRKTLEQKDELEKSLAESNDKDEEFKKLTQKLRDLEGFREK 1145
                  5555665555555444333689999**99999999999999999999999999975799************************************95 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 2.4
       KI67R    2 ttkipckSpqpepvntptsrkrqlktslqkvdveeel 38  
                  t ++p kSpq    ++   + r   t+   vd   el
  EFC39805.1 1184 TGELPTKSPQRRASRMAPFSSRGAPTNTDHVDR-LEL 1219
                  567899999999999988888888888888887.444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1341 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2822  (0.157399); expected 358.6 (0.02)
Passed bias filter:                      542  (0.0302304); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.22u 0.37s 00:00:01.59 Elapsed: 00:00:00.61
# Mc/sec: 6593.99
//
Query:       EFC39806.1  [L=329]
Description: hypothetical protein NAEGRDRAFT_60869 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.8e-72  242.1   0.0      4e-71  239.8   0.0    1.8  1  Actin     Actin
    2.8e-06   26.4   0.0    0.00083   18.3   0.0    2.2  2  MreB_Mbl  MreB/Mbl protein
  ------ inclusion threshold ------
       0.12   11.4   0.0       0.32   10.0   0.0    1.7  2  PilM_2    Type IV pilus assembly protein PilM;


Domain annotation for each model (and alignments):
>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  239.8   0.0   6.8e-75     4e-71      47     404 ..      11     323 ..       4     325 .. 0.94

  Alignments for each domain:
  == domain 1  score: 239.8 bits;  conditional E-value: 6.8e-75
       Actin  47 yvgdealtkrpelevrspv.edGvvedwdaveelwehvlkeelkvdpeehpllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstg 144
                 y+g+ al+++ ++  +s v ++Gv++dwd++e+l+e+ +keel++  +e ++  te+ lnp+++re+++ ++fE f++ +l ++ ++++s+fasg++++
  EFC39806.1  11 YIGE-ALKRMRGMVNESEVtRNGVIVDWDNFENLLEYLIKEELHMYASEECFFCTEAILNPKSERERMTSLLFERFGILGLDFGYQPIMSLFASGRNSA 108
                 6674.466666666666666******************************************************************************* PP

       Actin 145 lvvDsGasvtsvvpVldGyvLkkairrsdl.gGkaLteqlkellssknvevtprylikkkkvveaessaekeelekltesyktleeeevleeiKesvce 242
                 +++++G++ t +vp+ d +v+++ai rs++  G+ +t++l++ll++k                              + s++t++e e+++e+Ke+v+ 
  EFC39806.1 109 IIIEMGEDLTQIVPIWDCFVIENAILRSNIvNGRMVTDHLRQLLNQK------------------------------GFSFHTSSELEIVREMKEKVVC 177
                 ***************************99637**************8..............................78******************99 PP

       Actin 243 vsedpegdeeksssspeksYeLPDgseiklgeeRfkvpEiLFdpsligsesaleeekskllgiselivaainacdvdlrpeLlanivvtGGnsllpglt 341
                  + +p+       +s + +Y LPD ++i+++ e    +E+LF+p +++++           g++e+++++  +c++d r +L+ niv++GGnsl+ gl 
  EFC39806.1 178 FNGEPN------INSQKIDYFLPDLTKIEMSGEQNLSAECLFNPFILNKNVD---------GLHEMVHNSFTKCPIDSRLDLYGNIVLCGGNSLIDGLD 261
                 988887......5678899*************************99888766.........************************************** PP

       Actin 342 eRlekelaqlaskgvkvkiiapeeerkysaWiGGSiLAslgtfqqlwvskqEYeEqGssvver 404
                 +Rle+el  l++k+v+ k i+    +++s++iG+Si++s++t    w++k+ Y+E+G+++++r
  EFC39806.1 262 KRLEQELDLLLPKNVRKKFISMD-SPQFSSFIGASIYSSRSTITTGWITKESYQEYGPNICRR 323
                 **********************9.************************************987 PP

>> MreB_Mbl  MreB/Mbl protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.9   0.0   0.00082       4.9      48      86 ..      18      52 ..       5      68 .. 0.74
   2 !   18.3   0.0   1.4e-07   0.00083     246     299 ..     218     270 ..     202     279 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.00082
                TTTTS-GTTEEEE-SEETTEESSHHHHHHHHHHHHHHHH CS
    MreB_Mbl 48 kmlgktpgnikavrPlkdGviadlevaeellkyfikkvk 86
                +m g     ++     ++Gvi+d +  e+ll+y+ik+  
  EFC39806.1 18 RMRG----MVNESEVTRNGVIVDWDNFENLLEYLIKEEL 52
                4433....444445569******************9754 PP

  == domain 2  score: 18.3 bits;  conditional E-value: 1.4e-07
                 HHHHHHHHHHHHHHHHHTS-HHHHHHHHHH-EEEESGGGGSBTHHHHHHHHHSS CS
    MreB_Mbl 246 lkepvsaiveavkevLektppeLaadivdrgivltGGgallkgldkllseetgl 299
                 l+++v  + e+v++   k+p +   d++ + ivl+GG +l+ gldk l++e++l
  EFC39806.1 218 LNKNVDGLHEMVHNSFTKCPIDSRLDLYGN-IVLCGGNSLIDGLDKRLEQELDL 270
                 78899999*******************986.99*****************9987 PP

>> PilM_2  Type IV pilus assembly protein PilM;
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.28   1.7e+03      32      60 ..     129     157 ..     108     162 .. 0.80
   2 ?   10.0   0.0   5.3e-05      0.32     277     300 ..     247     270 ..     205     287 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.28
      PilM_2  32 ekdavvdreikdieavsealkrvvkklkt 60 
                  ++a+   +i +   v++ l++++++ + 
  EFC39806.1 129 IENAILRSNIVNGRMVTDHLRQLLNQKGF 157
                 57888999999999999999999988765 PP

  == domain 2  score: 10.0 bits;  conditional E-value: 5.3e-05
      PilM_2 277 kilLaGGtaslpgleelleeelgi 300
                 +i+L+GG++ + gl++ le+el++
  EFC39806.1 247 NIVLCGGNSLIDGLDKRLEQELDL 270
                 7*******************9975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       536  (0.0298957); expected 358.6 (0.02)
Passed bias filter:                      481  (0.026828); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.35s 00:00:00.99 Elapsed: 00:00:00.56
# Mc/sec: 1760.39
//
Query:       EFC39807.1  [L=697]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.7e-46  158.9   0.0      5e-46  157.4   0.0    1.7  1  Glyco_hydro_15  Glycosyl hydrolases family 15


Domain annotation for each model (and alignments):
>> Glyco_hydro_15  Glycosyl hydrolases family 15
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  157.4   0.0   2.8e-50     5e-46       4     378 ..     296     649 ..     293     693 .. 0.85

  Alignments for each domain:
  == domain 1  score: 157.4 bits;  conditional E-value: 2.8e-50
                     HHHHHHCBCSTTSSBTTS-TT-B-S-S-BSSS.........B--SEEHHHHHHHHHHHH................HH..HHHTTT-HCCHHHHHH CS
  Glyco_hydro_15   4 ldlylrnvktlilleqnpvtGlliASpstsdp.........DYrytWvRDsvyvilavwglgyr.........dedr..akayeleqslvklmrg 78 
                     ++ + r++ +l+ll+++  tG++ A+ sts+p         DYr+tW+RD+++++  ++++g+           e+r  +   +++qs +k +  
      EFC39807.1 296 REQVKRSALALKLLTYEK-TGAILAAASTSLPegiggvrnwDYRFTWIRDASFTLYSFMSIGFMeeatkfvkyLEARisEMNLKYKQSDEKGSPP 389
                     567899************.*******************************************552344466443333112222334555555556 PP

                     HHHHHHHHCTS-BTTB-TTSCGGGG--EE-TTS-B--S-..-S--BTTHHHHHHHHHHHHHCTTHCHCCCCHHHHTHHHHHHHHHHHTTS-EE-T CS
  Glyco_hydro_15  79 lleamvrqagkvekfketqstkgLhakyftktgstvvGddewghlQlDatslyllalaqmtasglqiistldevafvqnlvdYieaayktpdfgl 173
                      l+ m++++g+ e  + +  +   h++++++++++++G+ ++++lQlD++++ +  ++ + + g  i+++ ++    + +  ++++++++ d+g 
      EFC39807.1 390 PLQVMYSIDGEHELIE-RTID---HLSGYMNSKPVRIGNGAYDQLQLDIYGELMDSMYIYDKYGNSISYDFWKH--LRFITNWVCNNWDEKDEGV 478
                     79*********88877.5666...9*************************************************..888899************* PP

                     TS--ECEEHH..HHHHHHHHHHHHHHHHHHCT-HHHHCCHHHHHHHHHHHHHSTTT..GGGEETTCCECECSCH.....HHHTTS--S-BCHHHH CS
  Glyco_hydro_15 174 WEenqgeselnassvgmakAlleaideadlfgakgdaqlvektkdeilnklqgkygckrgfwplfntylildgsfaedkeqvqeyrealdaslll 268
                     WE+++g++++++s ++ ++ l++ai++a++    +d +++ k +++i +++     +++g+  +   ++  +gs            + ldas+l+
      EFC39807.1 479 WEVRGGRQHFVYSRIMTWVCLDRAIKIAQSRSFPADVDKWIKVRNQIFEQV-----IEKGYNRELESFTSFYGS------------DTLDASTLI 556
                     ***************************************************.....******************............********* PP

                     HHHHCS-TTS-TT-TT-TTTSHHHHHHHHHHHHHHHHHSGGGTT-STTS--SBTT--CGSS.SBSCT--BHHHHHHHHHHHHHHHHHHHHHTE-E CS
  Glyco_hydro_15 269 lpelyfvpaddvdeeyqnpqsprllaqslyildsllsegflavgeldplvrRysedvkpdk.lglsGrpyylctlwtvetlldelyekagkgrlw 362
                     +p + f ++ d            +++++++i +  ++ g+++++     v+Ry  ++ +d+  g++++ + lct+w    l +++ +  + g+  
      EFC39807.1 557 IPLVSFLSPSD----------TLVVNTIKAINKPPEENGLVSSSL----VYRYLVEKTDDGfSGGEEGTFNLCTFW----LIESIARACSYGESK 633
                     ***********..........*******************98885....***9888877651567888999*****....444444444444455 PP

                     EEECCCHHHHHHHTTT CS
  Glyco_hydro_15 363 glvryalglleklves 378
                      l+++ + +le+++  
      EFC39807.1 634 DLLQEGRMMLEQMITY 649
                     7899999999998877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (697 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       350  (0.0195214); expected 358.6 (0.02)
Passed bias filter:                      286  (0.0159518); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.71u 0.35s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 3850.23
//
Query:       EFC39808.1  [L=224]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.4e-11   44.7   0.9    2.8e-11   43.8   0.9    1.5  1  TLD       TLD


Domain annotation for each model (and alignments):
>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.8   0.9   1.5e-15   2.8e-11       1     136 [.      61     220 ..      61     223 .. 0.77

  Alignments for each domain:
  == domain 1  score: 43.8 bits;  conditional E-value: 1.5e-15
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnk.kfygdsesflfsl.spkfkvykstgknkaylntssdg...lgfGggqp 94 
                 l++++s+dg+s s ++++++++g +++++k++ +++fG+++s+++k +++  +++d+e+f f + ++++ +++  +++ +y +   ++   ++fG    
  EFC39808.1  61 LIFRASRDGFSDSDFHKHCDDQGKIVIILKSKCGDLFGGYTSESMKLDERgMYVKDEEMFTFRFdNNRLCIFRLLPEDRIYALYRYSSfhlFAFG---- 155
                 69*******************************************87777578999********999999****999988877777555679***.... PP

         TLD  95 kfsLwidsslekgtsrhs......etfengllsg..................aseerfkikdiEVW 136
                  + +wi ++ +++ ++ s      + f  + l +                       f i+d+EV+
  EFC39808.1 156 -YCFWIGTNANTSATSGShdemedHIFPECKLLKkeggnqvneygellenqyFPRIGFLIEDLEVY 220
                 .899**999999777655566666555444444345555555555555454434455666666666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (224 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       344  (0.0191868); expected 358.6 (0.02)
Passed bias filter:                      294  (0.016398); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.29s 00:00:00.71 Elapsed: 00:00:00.44
# Mc/sec: 1522.70
//
Query:       EFC39809.1  [L=117]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
      3e-07   30.1   0.3    4.7e-07   29.5   0.3    1.3  1  RRM_1         RNA recognition motif. (a.k.a. RRM, RBD, or RNP
  ------ inclusion threshold ------
      0.019   14.8   0.1      0.033   14.0   0.1    1.4  1  RRM_occluded  Occluded RNA-recognition motif
      0.097   12.7   0.1        0.2   11.7   0.1    1.5  1  Nup35_RRM_2   Nup53/35/40-type RNA recognition motif


Domain annotation for each model (and alignments):
>> RRM_1  RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.5   0.3   7.9e-11   4.7e-07       1      57 [.      15      71 ..      15      77 .. 0.94

  Alignments for each domain:
  == domain 1  score: 29.5 bits;  conditional E-value: 7.9e-11
                EEEESETTTSSHHHHHHHHHT.TSCEEEEEEEEETTTSEEEEEEEEESSHHHHHHHHH CS
       RRM_1  1 lfVgnLppdvteeeLkelFsk.fGpiksiklvrdetgkskgfafVeFeskedAekAle 57
                ++V  Lp+ + e++++e+F+k  G+i+si++++ ++      a ++F+++  AekA+e
  EFC39809.1 15 IVVFELPFVAEEKQIREFFEKvSGGISSIDVIK-ANALVFSSAVIQFNKEKGAEKAIE 71
                68999****************99**********.7**********************9 PP

>> RRM_occluded  Occluded RNA-recognition motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0   0.1   5.6e-06     0.033       2      55 ..      13      70 ..      12      82 .. 0.83

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 5.6e-06
  RRM_occluded  2 rtisllplsDtvnkariralveekegeikkivLvpd....heGAivefkdekiagkas 55
                  rti +++l+    +++ir+++e+ +g i  i +        ++A+++f++ek a ka+
    EFC39809.1 13 RTIVVFELPFVAEEKQIREFFEKVSGGISSIDVIKAnalvFSSAVIQFNKEKGAEKAI 70
                  89**********************8888888665541222589*********999985 PP

>> Nup35_RRM_2  Nup53/35/40-type RNA recognition motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.1   3.3e-05       0.2      14      52 ..      26      69 ..      23      70 .. 0.84

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3.3e-05
  Nup35_RRM_2 14 ielVlehFas.fGeIvkhyvp....kevsvmyvkfesekdaekA 52
                 ++ ++e+F+   G I  ++v        s+++++f +ek aekA
   EFC39809.1 26 EKQIREFFEKvSGGISSIDVIkanaLVFSSAVIQFNKEKGAEKA 69
                 6789*****66*********96665335899************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (117 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       454  (0.0253221); expected 358.6 (0.02)
Passed bias filter:                      361  (0.020135); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.41u 0.30s 00:00:00.71 Elapsed: 00:00:00.45
# Mc/sec: 782.29
//
Query:       EFC39810.1  [L=150]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (150 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1796  (0.100173); expected 358.6 (0.02)
Passed bias filter:                      453  (0.0252663); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.54
# Mc/sec: 835.35
//
Query:       EFC39811.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-13   48.7   0.8    1.4e-12   47.4   0.5    1.9  2  TP6A_N    Type IIB DNA topoisomerase


Domain annotation for each model (and alignments):
>> TP6A_N  Type IIB DNA topoisomerase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0      0.39     7e+03       8      21 ..      61      74 ..      60      75 .. 0.86
   2 !   47.4   0.5   7.8e-17   1.4e-12       4      62 .]     124     182 ..     121     182 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 0.39
                HHHHHHHHHHHTT- CS
      TP6A_N  8 kvlelihelleegk 21
                +vle++ +l+e+++
  EFC39811.1 61 YVLEFLFKLIENDE 74
                799*****999986 PP

  == domain 2  score: 47.4 bits;  conditional E-value: 7.8e-17
                 HHHHHHHHHHHHHHHTT--EEHHHHHHHGGGS-SSHHHHHHHHHHHHHHHTS-GGGGTE CS
      TP6A_N   4 aqllkvlelihelleegkvvTkRdiYYrdvelFksQaesdrliddievllgvsReeLnv 62 
                   ++++++ +h ll+ +k++T+R+++Y++v++F++Q +++r++  +  +l+v R+ Ln+
  EFC39811.1 124 HLVWLLMKDVHLLLNCRKKITQRELFYMNVTTFRDQIQCNRCLSTVGDVLKVDRSLLNI 182
                 5689******************************************************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       619  (0.0345251); expected 358.6 (0.02)
Passed bias filter:                      364  (0.0203023); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.54
# Mc/sec: 2089.64
//
Query:       EFC39812.1  [L=222]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.9e-40  136.7   0.5      9e-40  136.3   0.5    1.1  1  DUF775    Protein of unknown function (DUF775)
  ------ inclusion threshold ------
      0.056   13.8   0.1      0.094   13.1   0.1    1.3  1  P22_AR_N  P22_AR N-terminal domain


Domain annotation for each model (and alignments):
>> DUF775  Protein of unknown function (DUF775)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  136.3   0.5     1e-43     9e-40       1     197 [.       1     197 [.       1     198 [. 0.92

  Alignments for each domain:
  == domain 1  score: 136.3 bits;  conditional E-value: 1e-43
      DUF775   1 mFgvivagrpvqtelqqvsetkfvfslpk...aksishivvFllpnvtl.pegtaaavYlqlpekeefklLGalsneKpSAifkvknekss.seaesas 94 
                 mFg++ +grp+ ++++qv e+++++++p+    +sis++++F lpnv + p +++ ++Y++   ++++++L++l+ +KpS++++v  + +s s+++sa+
  EFC39812.1   1 MFGLVSPGRPCYANFNQVGENRWFIQIPDkvnGQSISELTIFALPNVGMpPLSHGFTIYISKD-SNNWEFLDFLTIDKPSTHIHVPLSFDSsSSVQSAF 98 
                 9***************************977789***************66699*******95.789*******************9988865566777 PP

      DUF775  95 eass.aeesstltiGisiEpleqvaaqlaelkaeqsassssaassskseessaavtkelaqkiiknafnylaSFad.ka........geevvplkafek 183
                 +  + +++ ++l +Gis+Ep++++++ ++++  +q++++s+              +++l++ i++++fn+++SF++  +        ++ v+p++ +++
  EFC39812.1  99 QGINyNNNVDQLFVGISLEPIDTINNLTCNAVGKQQMEQSQ--------------VQQLVKAIANDLFNFMSSFTKpYQvnesgtmrEMLVLPTNILDT 183
                 7666699*************************999987764..............99*******************7446899**99999********* PP

      DUF775 184 WwekFerklendpn 197
                 W +kF +kl+ +p+
  EFC39812.1 184 WLQKFLNKLRLNPH 197
                 ***********995 PP

>> P22_AR_N  P22_AR N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.1   0.1     1e-05     0.094      36      80 ..     141     188 ..     123     205 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.1 bits;  conditional E-value: 1e-05
    P22_AR_N  36 sQveKlkedeklssvvieit...vpsdgktremlclplrklpgwLakI 80 
                 +Q  K  +++ ++ +   +    v+++g  reml+lp + l  wL+k 
  EFC39812.1 141 QQLVKAIANDLFNFMSSFTKpyqVNESGTMREMLVLPTNILDTWLQKF 188
                 45555444555544443333345999*******************985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (222 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       694  (0.0387082); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.52
# Mc/sec: 1279.16
//
Query:       EFC39813.1  [L=136]
Description: hypothetical protein NAEGRDRAFT_81223 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.4e-05   23.5   0.7    5.5e-05   23.2   0.7    1.1  1  ASF1_hist_chap  ASF1 like histone chaperone


Domain annotation for each model (and alignments):
>> ASF1_hist_chap  ASF1 like histone chaperone
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.7     3e-09   5.5e-05       4     116 ..       6     119 ..       4     130 .. 0.84

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 3e-09
                     EEEEEEEESS-SEETTS-EEEEEEEEESS--SS-EEEEEEEESSSSSGGGEEEEEEEEEES--.SEEEEEEEEE----GGGSSSGGGSEEEEEEE CS
  ASF1_hist_chap   4 vnvtnvkvlnnpakfsdpfkfeitfeclekLeedlewkliyvgsaeseeedqeLdsvlvGPik.vGvnkFvfeadppdvskipkedvlgvtvill 97 
                     v ++ v++ n+   ++d f+++ ++++le+Le +++wk++yv    ++++  +L +  v   +    ++F+ + d ++++ + +  + +v+vi++
      EFC39813.1   6 VLLKRVTLENKAGLLEDGFVVDFSLNVLENLE-NVHWKITYVVDMANTKQSVVLGQSEVMNYSpSEETTFKYQIDRINLDGVSPMLLNNVAVIVV 99 
                     6678899999999******************7.69*******************999887665156789****************9999*99999 PP

                     EE.EETTEEEEEEEEEEEEE CS
  ASF1_hist_chap  98 ta.sYkeqeFvrvGYyvnne 116
                          k++e ++    v+ e
      EFC39813.1 100 ALvDQKDEELFKCSMVVQAE 119
                     75145667777766666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (136 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       503  (0.0280551); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.56u 0.30s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 783.81
//
Query:       EFC39814.1  [L=507]
Description: U4/U6-associated splicing factor HPRP3 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.8e-43  146.5  19.9    9.8e-43  146.5  19.9    2.5  2  PRP3      pre-mRNA processing factor 3 (PRP3)
    6.3e-26   91.2   0.0    6.3e-26   91.2   0.0    4.1  4  DUF1115   Protein of unknown function (DUF1115)


Domain annotation for each model (and alignments):
>> PRP3  pre-mRNA processing factor 3 (PRP3)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -5.0   6.5         2   1.8e+04      29      56 ..      12      45 ..       2      93 .. 0.45
   2 !  146.5  19.9   1.1e-46   9.8e-43       3     223 .]      96     345 ..      94     345 .. 0.80

  Alignments for each domain:
  == domain 1  score: -5.0 bits;  conditional E-value: 2
        PRP3 29 ikqaeqlrekaqleelkkeiaeeakka......g 56
                + q+++  +++q+e++ +  ae+++++       
  EFC39814.1 12 STQQQRAEHQQQQENDGRDGAEQKEEEvdygslI 45
                3333333333333333333333333334444440 PP

  == domain 2  score: 146.5 bits;  conditional E-value: 1.1e-46
        PRP3   3 yldprlka..kvkkrkkralkfvekGkfikqaeqlrekaqleelkkeiaeeakkaglesdlklaekapkk......................eedevpn 77 
                 ++d++l+   +++k+++r+l f+e+G+fi++a+ +re +++e++++ ++e+ +k+  e+++ ++ek+  +                       e+++p 
  EFC39814.1  96 FYDSTLSVpkAERKKRNRGLAFHEQGEFIEKAKMMRELEEEERQRALLKEQLEKERKEQEKIEKEKERLRliqeeleigelhmmlgcrriedFESTIP- 193
                 789999854345556699*****************99999999998887776666444333333333333577788889999999*****99888999. PP

        PRP3  78 dvEWWDavllkkkekkealkeeekkke......keeeees....klk.kitnyveHPvplkppkektkpaakplyLTkkErKklRrqrRkekekekqdk 165
                 d  WWD+++lk+ +k +++  +++ +           e++    k k     +veHP+ ++p k+k  + + pl+LTkkE+Kk+R+q+R ++eke+q k
  EFC39814.1 194 DAFWWDKKILKSCKKADENV-NNHVDIyqrdfdA---ENEvysiKEKlVKHDFVEHPIIVDPLKKKVDAGPLPLMLTKKEQKKMRTQQRIQREKENQRK 288
                 9*********9775444333.2222224445532...222222333456678**************999****************************** PP

        PRP3 166 irlGLepppepKvklsNLmrvlgdeavqdPtkvEaeVreqmaeRekkHeerNeeRklt 223
                 i lGL ppp+pK  + N m+ l   + qd t++E++++++++eR ++HeerN++ klt
  EFC39814.1 289 IALGLTPPPPPKANMGNYMKALLA-SGQDATELEMKIKKEIEERMQAHEERNNNEKLT 345
                 **********************85.569****************************97 PP

>> DUF1115  Protein of unknown function (DUF1115)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   1.2      0.13   1.1e+03      75      97 ..      14      36 ..       4      56 .. 0.44
   2 ?   -2.4   1.5      0.51   4.5e+03      72      92 ..     137     157 ..     108     170 .. 0.52
   3 ?   -8.7   9.9         2   1.8e+04      76      76 ..     330     330 ..     184     365 .. 0.71
   4 !   91.2   0.0   7.1e-30   6.3e-26       2     145 ..     369     497 ..     368     498 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.13
     DUF1115 75 keaakekkeeeekdedekeeekd 97
                +++ +e+++++e+d ++  e+k+
  EFC39814.1 14 QQQRAEHQQQQENDGRDGAEQKE 36
                11122222222222222222232 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.51
     DUF1115  72 eeekeaakekkeeeekdedek 92 
                 e++ +  ke+ e+e k++++ 
  EFC39814.1 137 ERQRALLKEQLEKERKEQEKI 157
                 222222222222222222222 PP

  == domain 3  score: -8.7 bits;  conditional E-value: 2
     DUF1115  76 e 76 
                 e
  EFC39814.1 330 E 330
                 1 PP

  == domain 4  score: 91.2 bits;  conditional E-value: 7.1e-30
     DUF1115   2 vfriksLsnpkhrfkvdknAkqlsltGvvllg......pkfnlvvveGgekaikkYkklmlrrikWteeeredeeeeeekeaakekkeeeekdedekee 94 
                 ++ i+++++p++rfk++  Ak+ ++tG+vl        ++  l+++eGg+k +kkY+ ++l++i+W++ e              + ++e++ +++++++
  EFC39814.1 369 LYSIPNIAHPQTRFKIN-TAKEKGITGAVLSYpsqtrdKDRILLIAEGGKKFLKKYDDVILNKIDWSKVE--------------GVQSENTIPTQSDNQ 452
                 699*************9.8**********999555544446**************************554..............333344444444433 PP

     DUF1115  95 ekdlsnnkcelvweGevkkrnFkkwkfkeceteeearevLekkgvehywdl 145
                 +      +++++w+G+v krnF+ +kf+++e+ee ++++L+++g+ hy+d+
  EFC39814.1 453 P------SARMLWKGTVLKRNFQYFKFQKFEDEESIKNYLNDHGCIHYFDV 497
                 3......3899**************************************96 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (507 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2983  (0.166378); expected 358.6 (0.02)
Passed bias filter:                      604  (0.0336884); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                        16  (0.000892409); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.78u 0.39s 00:00:01.17 Elapsed: 00:00:00.56
# Mc/sec: 2735.13
//
Query:       EFC39815.1  [L=766]
Description: viral A-type inclusion protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     0.0016   18.5  13.9     0.0016   18.5  13.9    4.1  5  TPR_MLP1_2       TPR/MLP1/MLP2-like protein
  ------ inclusion threshold ------
      0.058   13.8   0.2        1.7    9.1   0.0    3.1  2  YvfG             YvfG protein
       0.14   12.1   6.8          4    7.5   1.5    3.0  2  PilJ             Type IV pili methyl-accepting chemotaxis tra
        2.8    6.0  50.6       0.59    8.2   9.9    3.5  3  HOOK             HOOK protein


Domain annotation for each model (and alignments):
>> TPR_MLP1_2  TPR/MLP1/MLP2-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.1       1.1     5e+03     112     128 ..      46      62 ..      39      63 .. 0.83
   2 ?   -2.3   0.2      0.97   4.3e+03      98     116 ..     176     194 ..     147     197 .. 0.64
   3 ?    4.1  20.8      0.01        46       8     103 ..     440     535 ..     435     551 .. 0.90
   4 ?   -2.9   9.2       1.5   6.8e+03       2      72 ..     500     570 ..     499     575 .. 0.57
   5 !   18.5  13.9   3.5e-07    0.0016       2      89 ..     577     664 ..     576     671 .. 0.94

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 1.1
  TPR_MLP1_2 112 iedlneqNklLhdQlEs 128
                 + d ++ N +L+ Q E 
  EFC39815.1  46 LADQQQENGTLIAQVEL 62 
                 5789999*****99996 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 0.97
  TPR_MLP1_2  98 keelekelselekriedln 116
                 ++++ ++l+el  ++e+ +
  EFC39815.1 176 QQKYATKLEELHGKLEECK 194
                 3444455555555555544 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.01
  TPR_MLP1_2   8 eeikslkeekeeaeaklqklqedlekqaeiakeaqqkYerelvkhaedvkelqalreelnelkaeiaelkaeaesakaeleeseesweeqkeelek 103
                 +e+++l+++++e++ kl+++ ++ e+ +++ ++ q + ++ ++ + e+ ++l+a+ +e +elk  ++e k++ es ++ ++e++ + ++  ++l +
  EFC39815.1 440 KELTELSQKNSELNMKLSEITQQNEAYEKQIETLQSNLQSVILTKDETCTKLEAILKENEELKRLLEEHKKSSESHSKLIAEEQMKTSNLMTSLTE 535
                 7999**************************************************************************999999887776665554 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 1.5
  TPR_MLP1_2   2 elksleeeikslkeekeeaeaklqklqedlekqaeiakeaqqkYerelvkhaedvkelqalreelnelkae 72 
                 elk+l ee+k+ +e+ +++ a++q   ++l +   + +   + Y++ +   ++++ke ++l+++l+  +++
  EFC39815.1 500 ELKRLLEEHKKSSESHSKLIAEEQMKTSNLMTSLTEKELELEIYQKNMHISEDAMKESADLKKKLEASESK 570
                 55666666666666666666666655555555555555555556666666666666666666666555444 PP

  == domain 5  score: 18.5 bits;  conditional E-value: 3.5e-07
  TPR_MLP1_2   2 elksleeeikslkeekeeaeaklqklqedlekqaeiakeaqqkYerelvkhaedvkelqalreelnelkaeiaelkaeaesakaelee 89 
                 +++sle+e+k+++++ +++ a++  l++   +q+e++ e q+   +  +++++ +++l++++++l+el++ i++l++e e+a  ++ e
  EFC39815.1 577 QISSLETEVKNYESKHKQLLADMDLLKKTNDTQKESLDENQKTIDSLKLEKSTLTDNLSSVKNQLEELQKSITNLNKEKEAAILKNYE 664
                 789*****************************************************************************99766555 PP

>> YvfG  YvfG protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   0.0      0.16   7.3e+02      37      55 ..      42      60 ..      34      63 .. 0.84
   2 ?    9.1   0.0   0.00038       1.7      12      38 ..     456     482 ..     450     507 .. 0.85

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.16
                HHHHHHHSSS-HHHHHHHH CS
        YvfG 37 vssllaDrlaknavllkRi 55
                 ss+laD+   n  l+  +
  EFC39815.1 42 SSSILADQQQENGTLIAQV 60
                69**********9999765 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00038
                 HHHHHHC-SS.S-CCHHHHHHHHHHHH CS
        YvfG  12 lkeyieqneayedkiqalnaYYkvvvs 38 
                 l e  +qneaye++i+ l +  ++v+ 
  EFC39815.1 456 LSEITQQNEAYEKQIETLQSNLQSVIL 482
                 66889****************999975 PP

>> PilJ  Type IV pili methyl-accepting chemotaxis transducer N-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   1.5   0.00088         4      28      96 ..     440     516 ..     435     529 .. 0.57
   2 ?    6.3   0.3    0.0022       9.6      48      99 ..     610     659 ..     579     672 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00088
        PilJ  28 keallaaaga.......ydaaearaqlretiaqfdrtlaalrlgdpapgllvpaeavraqleaveqlWqelkkpa...e 96 
                 ke++++ + +       ++++++ ++ +++i++++ +l++  l+ ++ +  + + a+ ++ e++ +l +e kk+     
  EFC39815.1 440 KELTELSQKNselnmklSEITQQNEAYEKQIETLQSNLQSVILTKDE-TCTKLE-AILKENEELKRLLEEHKKSSeshS 516
                 55566666663333333566666666666666666666666666666.344444.677777777777766666664443 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0022
        PilJ  48 retiaqfdrtlaalrlgdpapgllvpaeavraqleaveqlWqelkkpaeaal 99 
                 +e++++ ++t+++l+l  ++ +      +v++qle++++   +l k  eaa+
  EFC39815.1 610 KESLDENQKTIDSLKLEKSTLTDNLS--SVKNQLEELQKSITNLNKEKEAAI 659
                 688999999*****999999777666..9***********999999876655 PP

>> HOOK  HOOK protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.1   0.4      0.68   3.1e+03     494     517 ..     169     192 ..     141     201 .. 0.43
   2 ?    3.4  28.4    0.0038        17     118     336 ..     375     593 ..     368     609 .. 0.63
   3 ?    8.2   9.9   0.00013      0.59     482     543 ..     608     669 ..     596     687 .. 0.85

  Alignments for each domain:
  == domain 1  score: -4.1 bits;  conditional E-value: 0.68
        HOOK 494 kneLetenrlanqrileLeaqvee 517
                 ++ +e  +++   +++eL+ ++ee
  EFC39815.1 169 LKYIEIIQQKYATKLEELHGKLEE 192
                 333333333333333333333333 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.0038
        HOOK 118 CekKqeyIqqimtl.eEsvqhvvmtaiQellske.glaslseeslgeldsqlrklleelkeaqeekd..elaQrcheldkqlsllqeEknaLlaenkkl 212
                   +K ++I+  ++l +E+v + v++  Q l + +   + ++    ++ d +  k++++l ++++ k+  el+Q+  el+++ls +++ ++a  +++++l
  EFC39815.1 375 YVNKSSFITPDLSLsDETVNELVKKHSQSLFKFKiKYSDIDDSLENSSDFSFVKTFSFLGSTKNSKEltELSQKNSELNMKLSEITQQNEAYEKQIETL 473
                 568999999999986799999*********99995556666666677778888999999888887766699************9999999999999999 PP

        HOOK 213 qerlselengeesgtiql..tskkylelqkqleqlqeelfrlEtarddyrlkceelekevlelqqrneeltslae....EaqaLkDEv....DvLresa 301
                 q++l+++  +++++ ++l  + k + el++ le+               +  +e   k ++e q+++ +l+++      E +  +  +    D+++esa
  EFC39815.1 474 QSNLQSVILTKDETCTKLeaILKENEELKRLLEE--------------HKKSSESHSKLIAEEQMKTSNLMTSLTekelELEIYQKNMhiseDAMKESA 558
                 9999988744443333110022222223333332..............223333333333333333333332222000022222222222227777777 PP

        HOOK 302 dkvkkleatvetykkkledlndLrrqvklleerna 336
                 d  kklea+    k +l +++ L  +vk  e +  
  EFC39815.1 559 DLKKKLEASESKSKGQLVQISSLETEVKNYESKHK 593
                 77777777777777777777777777777776654 PP

  == domain 3  score: 8.2 bits;  conditional E-value: 0.00013
        HOOK 482 elqelledanrrkneLetenrlanqrileLeaqveelqkalqeqgskaedssllkkkleehl 543
                 + +e l+++++++++L+ e+ + ++ ++++++q+eelqk+ ++ + ++e ++l++ + +e+l
  EFC39815.1 608 TQKESLDENQKTIDSLKLEKSTLTDNLSSVKNQLEELQKSITNLNKEKEAAILKNYEHKELL 669
                 34578**************************************9999999777766666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (766 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2836  (0.158179); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                       131  (0.0073066); expected 17.9 (0.001)
Passed Fwd filter:                        49  (0.002733); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 1.22u 0.29s 00:00:01.51 Elapsed: 00:00:00.56
# Mc/sec: 4144.09
//
Query:       EFC39816.1  [L=987]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      4e-14   52.9   3.5      4e-14   52.9   3.5    3.3  3  RGS             Regulator of G protein signaling domain
    3.1e-11   43.8  22.1    3.1e-11   43.8  22.1    4.8  4  SLX9            Ribosome biogenesis protein SLX9
  ------ inclusion threshold ------
       0.21   10.4   7.0       0.39    9.5   7.0    1.4  1  Androgen_recep  Androgen receptor


Domain annotation for each model (and alignments):
>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.3       1.8   1.1e+04      70      82 ..     142     154 ..     119     179 .. 0.49
   2 !    4.4   0.8    0.0072        43      23     103 ..     331     422 ..     316     434 .. 0.78
   3 !   52.9   3.5   6.7e-18     4e-14       4     117 ..     799     918 ..     796     919 .. 0.92

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 1.8
                 HHHHHHHHHHHCS CS
         RGS  70 kklreelekrlek 82 
                 kk+++e+e++ + 
  EFC39816.1 142 KKMKNEIEQFTNV 154
                 3334444433333 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.0072
                 TCTHHHHHHHH.HHHHHTSSHHHHHHHH.HHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS..........STTTTTTHHHHHHHHHHHHH CS
         RGS  23 fseenlsFwla.veefkkakeqeelkkk.akeIyneylapsspkelnidkklreelekrleke..........qpsrklfeeaqeevfellek 103
                 ++e+n +F+++ v+++kka+++e +++  ak I+ +y  p+s +  ni+k+l++ ++++ +            ++s + f ++  +v+e l+k
  EFC39816.1 331 TQEDNKDFLEKiVDGWKKASSKEVFLSSiAKLIFTNYK-PASYTLENIQKELFDCINTKSNIGtsniasnnlqNNSTEDFTAVYWKVYEQLKK 422
                 56788899988357799997777777776888999987.8888888*******9998886655667888888777777777777777777765 PP

  == domain 3  score: 52.9 bits;  conditional E-value: 6.7e-18
                 HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTS...SHHHHHHHHHHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS....STTTTTTHHHHH CS
         RGS   4 slledqpgrslFreFlesefseenlsFwlaveefkka...keqeelkkkakeIyneylapsspkelnidkklreelekrleke....qpsrklfeeaqe 95 
                  ll d++g++lF eF+e++ + en++++++ e ++++    ++++++k++k+I +++l++ss+ke+n++++ r+ +e+    +    ++s++++e +++
  EFC39816.1 799 ALLRDPSGMQLFYEFCEQQLCTENIELFKELEILEQRlsnISSSKRSKHIKSIHDRFLSSSSDKEVNVSHSSRKLVERERFSKkidvETSKTVLEFLKR 897
                 5899********************************999889999*****************************9987654444899************ PP

                 HHHHHHHHHHHHHHHTSHHHHH CS
         RGS  96 evfellekdsypkFlkselylr 117
                  v++ l  ds+++F++++ y++
  EFC39816.1 898 DVCTNL-FDSFSRFIQTKEYRT 918
                 *****9.59*********9986 PP

>> SLX9  Ribosome biogenesis protein SLX9
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.8  22.1   5.1e-15   3.1e-11       3     131 .]      68     175 ..      66     175 .. 0.83
   2 ?   -5.0   8.8         3   1.8e+04      25      98 ..     207     320 ..     194     326 .. 0.62
   3 ?   -0.8   0.9      0.31   1.9e+03      69     112 ..     693     734 ..     656     764 .. 0.66
   4 ?   -1.6   0.4      0.56   3.4e+03      14     107 ..     852     879 ..     821     906 .. 0.53

  Alignments for each domain:
  == domain 1  score: 43.8 bits;  conditional E-value: 5.1e-15
        SLX9   3 klsKkdKrkiKheaflsKieksisksaskkkkkrkrrpskklvtdlesLadaLpdleeeegekkekkekeqaqqgkvkkaekslkskpgalkrkkklek 101
                 k+ Kk+ +  K++ +l++i++  +k + +k+kk+  +++++ + +++++ + L+                +++ +++kk+ek +k++ + +k++kk+ k
  EFC39816.1  68 KTLKKQEKFEKRKGLLQRITE--TKESMNKNKKQ--QQKQQGIFSFDPMSKLLQ----------------NEETSDMKKPEKPKKESNEVAKKNKKM-K 145
                 67799999*************..66666666665..3469**************................233456677777677777888888888.* PP

        SLX9 102 kEmerfkkvLahpsfksnpfaaLrehisnt 131
                 +E+e+f++vL+hp f+snp++++++h++n+
  EFC39816.1 146 NEIEQFTNVLNHPVFQSNPLQVIQQHLKNK 175
                 ***************************995 PP

  == domain 2  score: -5.0 bits;  conditional E-value: 3
        SLX9  25 isksaskkkkkrkrrpskklvtdlesLadaLpdle.........................................eeege.kkekkekeqaqqgkvkk 81 
                 ++k++++k k + +r++++   ++es  +a   +                                          +++++ ++ ++  +q+qq+  ++
  EFC39816.1 207 YKKKQARKVKFNTKRAKESFDKNVESVDKAVAGVPpnimtsniglplggtapmsllknnkqpvkiltggsinpllqQQQQQqHQITSAHQQQQQQAPSE 305
                 556666666666666777777777777777776657777777777777777777777777777777777777776422222222233332333333333 PP

        SLX9  82 aekslkskpgalkrkkk 98 
                   +s + +++ +krk+ 
  EFC39816.1 306 --PSWRDEINREKRKEL 320
                 ..589999999999985 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.31
        SLX9  69 kekeqaqqgkvkkaek.slkskpgalkrkkklekkEmerfkkvLa 112
                 k+k+q+  +++++++k s+ ++ +++kr        m + k++L+
  EFC39816.1 693 KDKKQRHPNDINSSNKhSNDQSNSQEKR---FSLVNMPNSKNILN 734
                 3444444444444332233333333333...33445555555555 PP

  == domain 4  score: -1.6 bits;  conditional E-value: 0.56
        SLX9  14 heaflsKiek.sisksaskkkkkrkrrpskklvtdlesLadaLpdleeeegekkekkekeqaqqgkvkkaekslkskpgalkrkkklekkEmerf 107
                 h +fls  +  +++ s+s++k+                                                                    E+erf
  EFC39816.1 852 HDRFLSSSSDkEVNVSHSSRKLV-------------------------------------------------------------------ERERF 879
                 22222222223222222222222...................................................................33333 PP

>> Androgen_recep  Androgen receptor
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   7.0   6.5e-05      0.39     161     211 ..     252     302 ..     115     314 .. 0.64

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 6.5e-05
  Androgen_recep 161 sllgpsfpglsscsadlkdilaeastmqllqqqqqehhhqqhqhqqqqqqe 211
                      l g +   l     +   il+  s   llqqqqq++h+    hqqqqqq 
      EFC39816.1 252 PLGGTAPMSLLKNNKQPVKILTGGSINPLLQQQQQQQHQITSAHQQQQQQA 302
                     4444444455555556667999999999********999999999999885 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (987 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2772  (0.15461); expected 358.6 (0.02)
Passed bias filter:                      426  (0.0237604); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.94u 0.30s 00:00:01.24 Elapsed: 00:00:00.53
# Mc/sec: 5641.51
//
Query:       EFC39817.1  [L=523]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.8e-13   50.7  54.4       0.05   14.5   0.5   10.7 10  SHIPPO-rpt  Sperm-tail PG-rich repeat
  ------ inclusion threshold ------
        9.1    5.6  10.7        4.3    6.7   0.9    3.4  3  HMMR_N      Hyaluronan mediated motility receptor N-terminal


Domain annotation for each model (and alignments):
>> SHIPPO-rpt  Sperm-tail PG-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.0   0.3    0.0058        52       3      29 ..      23      50 ..      21      52 .. 0.85
   2 !   13.2   0.2   1.5e-05      0.14       1      22 [.      61      81 ..      61      90 .. 0.71
   3 !    5.5   4.3    0.0041        37       1      12 [.      99     118 ..      99     166 .. 0.78
   4 !    4.9   0.0    0.0061        55       3      16 ..     178     192 ..     176     203 .. 0.80
   5 !   14.5   0.5   5.6e-06      0.05       1      31 []     211     239 ..     211     239 .. 0.79
   6 !    9.7   2.1    0.0002       1.8       1      24 [.     251     280 ..     251     291 .. 0.70
   7 ?    1.6   0.4     0.067   6.1e+02       2       7 ..     291     296 ..     290     312 .. 0.86
   8 !    9.7   0.6   0.00019       1.7       2      25 ..     332     356 ..     332     365 .. 0.81
   9 !   11.9   0.3   3.8e-05      0.34       2      31 .]     374     405 ..     373     405 .. 0.90
  10 !    5.3   0.1    0.0047        42       3      11 ..     501     509 ..     499     519 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.0058
  SHIPPO-rpt  3 GPGtYkpnknvpsnksaPkys....fGqrkr 29
                GPG+Y      p   ++Pky     f+++kr
  EFC39817.1 23 GPGSYISHE--PFL-KQPKYAsapfFSTEKR 50
                9********..888.8999998888888887 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 1.5e-05
  SHIPPO-rpt  1 lPGPGtYkpnknvpsnksaPky 22
                +PGPGtY+ ++ ++s+   ++ 
  EFC39817.1 61 TPGPGTYSSPTAFTSK-TDRSS 81
                7**********77777.44444 PP

  == domain 3  score: 5.5 bits;  conditional E-value: 0.0041
  SHIPPO-rpt   1 lPGPGtYkpnk........n 12 
                 +PGPG+Y +++        +
  EFC39817.1  99 NPGPGSYQVKSdidsflekK 118
                 7********99888766641 PP

  == domain 4  score: 4.9 bits;  conditional E-value: 0.0061
  SHIPPO-rpt   3 GPGtYkpnk.nvpsn 16 
                 GPG+Y ++  ++p++
  EFC39817.1 178 GPGQYFVEEiTAPRK 192
                 9*******9655555 PP

  == domain 5  score: 14.5 bits;  conditional E-value: 5.6e-06
  SHIPPO-rpt   1 lPGPGtYkpnknvpsnksaPkys..fGqrkrds 31 
                 +PGPG+Y+ +   +    +++y   fG+r+++s
  EFC39817.1 211 NPGPGAYDSKV--NDM--SRSYGsiFGSRTQRS 239
                 7**********..555..5555556****9986 PP

  == domain 6  score: 9.7 bits;  conditional E-value: 0.0002
  SHIPPO-rpt   1 lPGPGtYkpnk.nvpsn.ksaPkys....f 24 
                 + GPG+Y+ +  ++ ++ k++P  s     
  EFC39817.1 251 NLGPGAYDSKEpKLAHKtKHQPFGSttsrP 280
                 57*********8777777788866644440 PP

  == domain 7  score: 1.6 bits;  conditional E-value: 0.067
  SHIPPO-rpt   2 PGPGtY 7  
                 PGPG Y
  EFC39817.1 291 PGPGEY 296
                 ****99 PP

  == domain 8  score: 9.7 bits;  conditional E-value: 0.00019
  SHIPPO-rpt   2 PGPGtYkpnknvpsn.ksaPkysfG 25 
                 PGPG+Y+   ++++  +++P   fG
  EFC39817.1 332 PGPGSYNDSNYLTNDlTKKPRGAFG 356
                 9*********888888888877755 PP

  == domain 9  score: 11.9 bits;  conditional E-value: 3.8e-05
  SHIPPO-rpt   2 PGPGtYkpnk...nvpsnksaPkysfGqrkrds 31 
                 P PG+Y+++    +v +  +a++ +f +r+ +s
  EFC39817.1 374 PPPGSYNVPEklnQVRKT-DARSSTFQSRTTRS 405
                 99*********9988888.999******99876 PP

  == domain 10  score: 5.3 bits;  conditional E-value: 0.0047
  SHIPPO-rpt   3 GPGtYkpnk 11 
                 GPGtY+  +
  EFC39817.1 501 GPGTYDHSP 509
                 9*****877 PP

>> HMMR_N  Hyaluronan mediated motility receptor N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.1   0.3     0.057   5.1e+02       5      15 ..     100     110 ..      98     148 .. 0.77
   2 ?    3.4   0.2    0.0047        42       5      24 ..     212     231 ..     209     272 .. 0.83
   3 ?    6.7   0.9   0.00048       4.3       3      42 ..     372     411 ..     370     449 .. 0.74

  Alignments for each domain:
  == domain 1  score: -0.1 bits;  conditional E-value: 0.057
      HMMR_N   5 PppGaYdvKts 15 
                 P pG+Y vK+ 
  EFC39817.1 100 PGPGSYQVKSD 110
                 99******975 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.0047
      HMMR_N   5 PppGaYdvKtsdalkgpvsF 24 
                 P pGaYd K +d++++  s 
  EFC39817.1 212 PGPGAYDSKVNDMSRSYGSI 231
                 99************998885 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.00048
      HMMR_N   3 caPppGaYdvKtsdalkgpvsFeksqRfkkqk.esqqnlss 42 
                  aPppG+Y+v ++   +   +  +s+ f+ ++ +s+ n ++
  EFC39817.1 372 KAPPPGSYNV-PEKLNQVRKTDARSSTFQSRTtRSSDNNER 411
                 69********.999999999999*****9777433333222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       412  (0.0229795); expected 358.6 (0.02)
Passed bias filter:                      287  (0.0160076); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.50
# Mc/sec: 3132.17
//
Query:       EFC39818.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    6.5e-29  100.1   0.1    1.5e-28   98.9   0.0    1.7  2  Pirin     Pirin
    2.2e-24   85.8   0.2      1e-23   83.6   0.2    2.0  2  Pirin_C   Pirin C-terminal cupin domain


Domain annotation for each model (and alignments):
>> Pirin  Pirin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   98.9   0.0   1.7e-32   1.5e-28       2     108 .]      27     123 ..      26     123 .. 0.92
   2 ?   -3.5   0.0       1.2     1e+04      50      61 ..     198     209 ..     191     218 .. 0.76

  Alignments for each domain:
  == domain 1  score: 98.9 bits;  conditional E-value: 1.7e-32
                 EEECCGTCC.TTCCEECTCEECCEEESS.S.ETTEEEET-EEEEEEEBSEEEEEEEECSEEEEEETTS-EEEEETT-EEEEE-TT-EEEEEEE-SSSS- CS
       Pirin   2 vrvrralgkaaelqsvdpFlfldefdpaelevgeedvigagfpphphrgletvtylleGevehrDslGnkgvirpGdvqwmtAgsGivhsEmneeeees 100
                 v+v r++g+ ++++  dpFl+lde++  +         + gfp+hph+g+et++y+l G+ +hrDslG++g +++Gd+qwmtAg+Gi h+E++  + ++
  EFC39818.1  27 VKVCRTIGG-PTVSVHDPFLLLDEAKIPNA--------KNGFPEHPHKGFETLSYILTGQTRHRDSLGRSGYLSSGDAQWMTAGRGIRHEETPIGD-GP 115
                 567778888.899999*******9994444........48*******************************************************6.** PP

                 EEEEEEEE CS
       Pirin 101 leglqlWv 108
                 ++g+q+W+
  EFC39818.1 116 MHGFQIWI 123
                 *******8 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 1.2
                 SEEEEEEEECSE CS
       Pirin  50 gletvtylleGe 61 
                 g++ + yl+eG+
  EFC39818.1 198 GFQGLIYLFEGN 209
                 777788888886 PP

>> Pirin_C  Pirin C-terminal cupin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0      0.22     2e+03      17      34 ..      64      81 ..      49     106 .. 0.68
   2 !   83.6   0.2   1.1e-27     1e-23       8     103 ..     187     283 .]     179     283 .] 0.91

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.22
                -TT-EEEEEEEES-EEES CS
     Pirin_C 17 pegleaavyvleGelevg 34
                 +g+e++ y+l+G+ +  
  EFC39818.1 64 HKGFETLSYILTGQTRHR 81
                688999999999987644 PP

  == domain 2  score: 83.6 bits;  conditional E-value: 1.1e-27
                 TT-EEEEE--TT-EEEEEEEES-EEESSTTEEE-TTEEEEE-...SSSEEEEE--SS-EEEEEEEE----S--EEETTEEESSHHHHHHHHHHHHTT-T CS
     Pirin_C   8 agaelelplpegleaavyvleGelevggerseieeeqlavlg...dgdslvvkaeekgarvlLlaGePlgepvvqyGpfVmntkeeieqafedyregrf 103
                 +++++  ++p+g++ ++y +eG++ +++++  + e++ ++++   ++++ +++++++++++l+l+G+P++epv+ +GpfVmnt+eei+qa+e+y +g f
  EFC39818.1 187 KNEKFIETIPKGFQGLIYLFEGNGIFENQQ--VVEKSAVLFDetiENTQFEFESTSDQVQFLILSGQPIKEPVARQGPFVMNTREEIMQAYEEYYSGVF 283
                 456677779********************6..8899999999899999**********************************************98876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       339  (0.0189079); expected 358.6 (0.02)
Passed bias filter:                      302  (0.0168442); expected 358.6 (0.02)
Passed Vit filter:                        18  (0.00100396); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.59u 0.30s 00:00:00.88 Elapsed: 00:00:00.53
# Mc/sec: 1616.47
//
Query:       EFC39819.1  [L=907]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.1e-11   44.7   0.0      2e-11   43.8   0.0    1.4  1  Pkinase      Protein kinase domain
    6.3e-07   29.9   0.0    0.00067   20.2   0.0    4.1  4  RCC1         Regulator of chromosome condensation (RCC1) repe
    2.7e-05   23.6   0.0    4.7e-05   22.8   0.0    1.4  1  Pkinase_Tyr  Protein tyrosine kinase
    0.00027   20.7   2.8        1.1    9.1   0.1    4.5  4  RCC1_2       Regulator of chromosome condensation (RCC1) repe


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   43.8   0.0   4.4e-15     2e-11     136     259 ..     681     808 ..     631     811 .. 0.78

  Alignments for each domain:
  == domain 1  score: 43.8 bits;  conditional E-value: 4.4e-15
                 E...EEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT...SHH... CS
     Pkinase 136 e...lKitDFGlakelessskltsfvgtseYlAPEvl.keneyskkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilg...etkekl 227
                 e   + i+DFGl +  +  + + sf gt+  l+PE   ++ +++k++D++slG+++yellt +     + ++++++  +++  k+ +  +       + 
  EFC39819.1 681 EaikIAIGDFGLLTSTNDLN-TISFRGTPITLSPECStGNFKIDKNSDIFSLGCVFYELLTLEIQIIRNVKNQETKFLMHEAIKTDE--NethSIICNK 776
                 23337789********9988.99*************9556677******************99877755555555555555222222..2323444555 PP

                 HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 228 peaseiseeakdllkkllkkdpkkRltaeell 259
                  +++ i+e +++l+ ++l+  p +R+t++ ++
  EFC39819.1 777 LKNNGIPELIIRLVISMLQLHPLTRPTIDTIV 808
                 566667*********************99887 PP

>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   1.5e-07   0.00067       3      41 ..     243     284 ..     241     293 .. 0.78
   2 ?   -0.5   0.0      0.45     2e+03       1      15 [.     296     310 ..     296     335 .. 0.67
   3 ?    4.1   0.0     0.016        72       4      46 ..     387     432 ..     386     436 .. 0.66
   4 ?   -3.3   0.0       3.4   1.5e+04      29      45 ..     674     690 ..     669     690 .. 0.77

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 1.5e-07
                 EEEEEE--GGGTTSSSS---E.EEEEE-..GGGTTS-EEEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesv.lvPtkv..eglsgnrvvkva 41 
                 +++  G+n+++qLGlg+++    +Pt++  ++++g++++k++
  EFC39819.1 243 SIWVAGNNNNYQLGLGHNKPLtQIPTRLqfNNFKGEKIKKIT 284
                 68999*************666567****54555555999986 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.45
                 TTEEEEEE--GGGTT CS
        RCC1   1 dGrVysWGrndyGqL 15 
                 +G++y++G n y   
  EFC39819.1 296 SGNLYGCGINYYSDI 310
                 599999999988655 PP

  == domain 3  score: 4.1 bits;  conditional E-value: 0.016
                 EEEEE--GGGTTSSSS-.....--EEEEEE-GGGTTS..-EEEEEEETTE CS
        RCC1   4 VysWGrndyGqLGlgtt.....esvlvPtkveglsgn..rvvkvacGddh 46 
                 +y  G n++G  Gl +t     e      k++ + ++  +++++ c  + 
  EFC39819.1 387 IYVYGENQFGKFGLNHTndiygEF----EKLTYFIEQdiPIIDIECSKNN 432
                 89************9995444322....3555555555666666666665 PP

  == domain 4  score: -3.3 bits;  conditional E-value: 3.4
                 -GGGTTS-EEEEEEETT CS
        RCC1  29 veglsgnrvvkvacGdd 45 
                 +++ ++ +++k+a Gd+
  EFC39819.1 674 IAFQTSMEAIKIAIGDF 690
                 555556699*****985 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.8   0.0   1.1e-08   4.7e-05     141     256 ..     684     808 ..     676     811 .. 0.62

  Alignments for each domain:
  == domain 1  score: 22.8 bits;  conditional E-value: 1.1e-08
                  EEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHH.HSEEEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHH....HHHHHHTTEE........S- CS
  Pkinase_Tyr 141 vvkisDfGLardiekddeyvkkeeaklpvkWmapEslk.ekkftsksDvWsfGvllwEiftlgespypglknee....vleklkegkr........le 225
                  ++ i+DfGL  ++ +d ++   + + +p+  ++pE+ + + k+ ++sD++s G + +E++tl  + ++++kn+e    + e++k++++          
   EFC39819.1 684 KIAIGDFGLLTST-NDLNTI--SFRGTPIT-LSPECSTgNFKIDKNSDIFSLGCVFYELLTLEIQIIRNVKNQEtkflMHEAIKTDENethsiicnKL 777
                  67899******99.444444..34445665.67887661567****************************9999344333333332221111111112 PP

                  BBTTSBHHHHHHHHHHT-SSGGGS--HHHHH CS
  Pkinase_Tyr 226 kpekcpeelyelmkkcweedpeeRptfselv 256
                  k++ +pe + +l+ + ++ +p  Rpt+ ++v
   EFC39819.1 778 KNNGIPELIIRLVISMLQLHPLTRPTIDTIV 808
                  2333445555555566666666666666555 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.1     0.032   1.4e+02      11      30 .]     235     254 ..     232     254 .. 0.89
   2 !    9.1   0.1   0.00025       1.1      11      27 ..     290     306 ..     288     308 .. 0.91
   3 ?   -1.8   0.0      0.65   2.9e+03      12      29 ..     379     396 ..     368     396 .. 0.76
   4 !    5.5   0.1    0.0033        15       1      24 [.     423     446 ..     423     450 .. 0.86

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.032
      RCC1_2  11 scaLtedGeVlcWGsNsdGQ 30 
                 +++++ed  ++  G+N++ Q
  EFC39819.1 235 TFIVMEDESIWVAGNNNNYQ 254
                 67899***********9977 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.00025
      RCC1_2  11 scaLtedGeVlcWGsNs 27 
                 +++Lte+G+++++G N 
  EFC39819.1 290 TLFLTESGNLYGCGINY 306
                 799***********986 PP

  == domain 3  score: -1.8 bits;  conditional E-value: 0.65
      RCC1_2  12 caLtedGeVlcWGsNsdG 29 
                 ++Lt++ +++ +G N +G
  EFC39819.1 379 LILTSTFNIYVYGENQFG 396
                 677777789999999988 PP

  == domain 4  score: 5.5 bits;  conditional E-value: 0.0033
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWG 24 
                 ++++ +  +   +L+++G V+c G
  EFC39819.1 423 IIDIECSKNNCYFLSNSGSVYCSG 446
                 6778888888889*********98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (907 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1364  (0.0760779); expected 358.6 (0.02)
Passed bias filter:                      374  (0.0208601); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.82u 0.33s 00:00:01.14 Elapsed: 00:00:00.52
# Mc/sec: 5275.47
//
Query:       EFC39820.1  [L=151]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.7e-21   72.2   9.9    4.9e-07   28.8   0.5    3.5  3  EF-hand_1     EF hand
      4e-20   72.0  17.1    1.7e-11   44.4   3.2    2.3  2  EF-hand_7     EF-hand domain pair
    4.2e-18   64.9  10.2    2.4e-06   27.3   0.5    3.2  3  EF-hand_8     EF-hand domain pair
    1.4e-17   62.0  12.0      1e-05   25.1   0.5    3.7  3  EF-hand_6     EF-hand domain
    4.5e-16   57.5   6.9    4.8e-05   22.7   0.2    3.3  3  EF-hand_5     EF hand
    4.1e-07   29.9  12.7     0.0019   18.1   0.8    3.1  3  EF-hand_4     Cytoskeletal-regulatory complex EF hand
      0.001   19.3   9.2     0.0058   16.9   6.4    2.7  2  SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca
  ------ inclusion threshold ------
      0.011   13.6   0.7      0.013   13.4   0.7    1.0  1  PolC_DP2      DNA polymerase II large subunit DP2
      0.043   13.8   0.2          1    9.4   0.0    2.8  3  Vps23_core    Vps23 core domain
        0.1   13.0   0.2         14    6.1   0.0    2.9  3  EF-hand_9     EF-hand domain
       0.24   11.3   7.5        3.7    7.4   0.3    2.9  3  Caleosin      Caleosin related protein


Domain annotation for each model (and alignments):
>> EF-hand_1  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.0   0.5   2.5e-09     4e-06       6      26 ..      16      36 ..      14      39 .. 0.93
   2 !   22.3   0.1   3.6e-08   5.8e-05       5      28 ..      81     104 ..      77     105 .. 0.89
   3 !   28.8   0.5     3e-10   4.9e-07       3      28 ..     121     146 ..     119     147 .. 0.91

  Alignments for each domain:
  == domain 1  score: 26.0 bits;  conditional E-value: 2.5e-09
                HHHHTTTSSSEEEHHHHHHHH CS
   EF-hand_1  6 FrefDkDgdGkIdfeEfkell 26
                F++fD+D++GkIdf Ef+ ++
  EFC39820.1 16 FNLFDTDHSGKIDFREFVVAF 36
                99***************9887 PP

  == domain 2  score: 22.3 bits;  conditional E-value: 3.6e-08
                 HHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   5 iFrefDkDgdGkIdfeEfkellkk 28 
                 +F+ fD ++d  I+f+E++++ ++
  EFC39820.1  81 LFNTFDINKDNSITFDELLHMRRS 104
                 7******************99776 PP

  == domain 3  score: 28.8 bits;  conditional E-value: 3e-10
                 HHHHHHHTTTSSSEEEHHHHHHHHHH CS
   EF-hand_1   3 keiFrefDkDgdGkIdfeEfkellkk 28 
                 + iF+ +D+D++G Idf+Ef++++k+
  EFC39820.1 121 RIIFDQLDTDKNGIIDFNEFVHAFKS 146
                 669********************996 PP

>> EF-hand_7  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.9   6.1   2.7e-13   4.4e-10       4      69 ..      12     101 ..       9     103 .. 0.89
   2 !   44.4   3.2   1.1e-14   1.7e-11       1      71 []      75     145 ..      75     145 .. 0.87

  Alignments for each domain:
  == domain 1  score: 39.9 bits;  conditional E-value: 2.7e-13
   EF-hand_7   4 lkeaFkelDtdgdgyldkeellrllrkifqga........................gegsklsdeelellfkefDtdkdGvisfdEFlkl 69 
                 ++  F+++Dtd++g++d +e+  ++  ++ +                           +++ +++ l +lf+ fD +kd +i+fdE+l++
  EFC39820.1  12 IENHFNLFDTDHSGKIDFREFVVAFLMFYNQLnnnnnnnlnnninnnnnlnnnnnlNNNNNNTEQVLYHLFNTFDINKDNSITFDELLHM 101
                 6778****************8887777777778888********************55555599**********************9875 PP

  == domain 2  score: 44.4 bits;  conditional E-value: 1.1e-14
   EF-hand_7   1 eeklkeaFkelDtdgdgyldkeellrllrkifqgagegsklsdeelellfkefDtdkdGvisfdEFlklyr 71 
                 e++l+  F+ +D ++d++++ +ell++ r+++ +   +++    e + +f+ +Dtdk+G i+f+EF+++++
  EFC39820.1  75 EQVLYHLFNTFDINKDNSITFDELLHMRRSMSKFQNLNENQLLNETRIIFDQLDTDKNGIIDFNEFVHAFK 145
                 5799*********************9999987666444444557899********************9985 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.6   0.5   4.2e-08   6.8e-05      32      53 ..      16      37 ..      12      38 .. 0.92
   2 !   20.6   0.2   1.8e-07   0.00029      24      49 ..      74      99 ..      67     104 .. 0.92
   3 !   27.3   0.5   1.5e-09   2.4e-06      26      52 ..     118     144 ..     101     146 .. 0.91

  Alignments for each domain:
  == domain 1  score: 22.6 bits;  conditional E-value: 4.2e-08
   EF-hand_8 32 frefDtdgdGkisfeEFcvlle 53
                f++fDtd++Gki+f EF+v + 
  EFC39820.1 16 FNLFDTDHSGKIDFREFVVAFL 37
                9*****************9985 PP

  == domain 2  score: 20.6 bits;  conditional E-value: 1.8e-07
   EF-hand_8 24 seeevdilfrefDtdgdGkisfeEFc 49
                +e+ + +lf++fD+++d+ i+f+E +
  EFC39820.1 74 TEQVLYHLFNTFDINKDNSITFDELL 99
                68899*******************86 PP

  == domain 3  score: 27.3 bits;  conditional E-value: 1.5e-09
   EF-hand_8  26 eevdilfrefDtdgdGkisfeEFcvll 52 
                 +e +i+f+ +Dtd++G+i+f+EF+  +
  EFC39820.1 118 NETRIIFDQLDTDKNGIIDFNEFVHAF 144
                 5899*******************9776 PP

>> EF-hand_6  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   1.1   4.4e-08   7.2e-05       4      26 ..      14      36 ..      11      46 .. 0.86
   2 !   20.7   0.1   1.6e-07   0.00026       2      25 ..      78     101 ..      77     106 .. 0.91
   3 !   25.1   0.5   6.3e-09     1e-05       5      29 ..     123     146 ..     119     148 .. 0.91

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 4.4e-08
   EF-hand_6  4 eaFklfDkdgdGkidaeElrkal 26
                  F+lfD+d++Gkid+ E++ a+
  EFC39820.1 14 NHFNLFDTDHSGKIDFREFVVAF 36
                56*****************7654 PP

  == domain 2  score: 20.7 bits;  conditional E-value: 1.6e-07
   EF-hand_6   2 lreaFklfDkdgdGkidaeElrka 25 
                 l+++F+ fD ++d++i+++El ++
  EFC39820.1  78 LYHLFNTFDINKDNSITFDELLHM 101
                 689******************987 PP

  == domain 3  score: 25.1 bits;  conditional E-value: 6.3e-09
   EF-hand_6   5 aFklfDkdgdGkidaeElrkalrka 29 
                 +F+++D+d++G id++E+++a++ +
  EFC39820.1 123 IFDQLDTDKNGIIDFNEFVHAFK-S 146
                 8********************99.5 PP

>> EF-hand_5  EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.7   0.2   2.9e-08   4.8e-05       3      21 ..      14      32 ..      12      38 .. 0.86
   2 !   18.1   0.0   8.2e-07    0.0013       3      22 ..      80      99 ..      78     105 .. 0.88
   3 !   19.0   0.7   4.3e-07   0.00071       4      21 ..     123     140 ..     121     145 .. 0.90

  Alignments for each domain:
  == domain 1  score: 22.7 bits;  conditional E-value: 2.9e-08
                HHHHHH-SS-SSCE-HHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeEL 21
                  F+ +D++++GkI++ E+
  EFC39820.1 14 NHFNLFDTDHSGKIDFREF 32
                45****************9 PP

  == domain 2  score: 18.1 bits;  conditional E-value: 8.2e-07
                HHHHHH-SS-SSCE-HHHHH CS
   EF-hand_5  3 dtFqaiDlNgDGkIskeELk 22
                ++F+ +D N+D  I+++EL 
  EFC39820.1 80 HLFNTFDINKDNSITFDELL 99
                68****************94 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 4.3e-07
                 HHHHH-SS-SSCE-HHHH CS
   EF-hand_5   4 tFqaiDlNgDGkIskeEL 21 
                  F+++D+++ G I++ E+
  EFC39820.1 123 IFDQLDTDKNGIIDFNEF 140
                 5****************9 PP

>> EF-hand_4  Cytoskeletal-regulatory complex EF hand
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.8   1.2e-06    0.0019      46      82 ..      13      49 ..       5      58 .. 0.83
   2 !    9.0   2.4   0.00083       1.4      22      72 ..      57     105 ..      48     120 .. 0.69
   3 !   10.4   0.3    0.0003      0.49      46      70 ..     121     145 ..     102     150 .. 0.73

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.2e-06
   EF-hand_4 46 ekiwdladidedgkldfeefciamrlifdlvngeikd 82
                e+ ++l d d+ gk+df ef++a  + ++ +n++ ++
  EFC39820.1 13 ENHFNLFDTDHSGKIDFREFVVAFLMFYNQLNNNNNN 49
                5678999*********************999877653 PP

  == domain 2  score: 9.0 bits;  conditional E-value: 0.00083
   EF-hand_4  22 ednkltgdkvapvlknskleedklekiwdladidedgkldfeefciamrli 72 
                 ++n+l++    ++ +n + +e+ l ++++  di++d+++ f+e+  + r +
  EFC39820.1  57 NNNNLNN--NNNLNNNNNNTEQVLYHLFNTFDINKDNSITFDELLHMRRSM 105
                 3333333..34555677788999********************87655544 PP

  == domain 3  score: 10.4 bits;  conditional E-value: 0.0003
   EF-hand_4  46 ekiwdladidedgkldfeefciamr 70 
                   i+d  d d++g +df+ef+ a +
  EFC39820.1 121 RIIFDQLDTDKNGIIDFNEFVHAFK 145
                 4589999*************98765 PP

>> SPARC_Ca_bdg  Secreted protein acidic and rich in cysteine Ca binding region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.0   0.0      0.32   5.2e+02      90     111 ..      12      33 ..       6      35 .. 0.83
   2 !   16.9   6.4   3.6e-06    0.0058      31     112 ..      47     142 ..      36     143 .. 0.68

  Alignments for each domain:
  == domain 1  score: 1.0 bits;  conditional E-value: 0.32
  SPARC_Ca_bdg  90 ikpflescDadkdkkislkEwc 111
                   i++ ++  D+d+ +ki+ +E++
    EFC39820.1  12 IENHFNLFDTDHSGKIDFREFV 33 
                   5667888899999999999986 PP

  == domain 2  score: 16.9 bits;  conditional E-value: 3.6e-06
  SPARC_Ca_bdg  31 eeek......ehleelekkeeeknlkeckepvawkFsklDtnsdkvlsksELaplraplvklehC........ikpflescDadkdkkislkEwce 112
                   ++++      ++ + +++++ ++n +++++ +   F+++D n+d++++  EL ++r ++ k+++         ++  +++ D+dk++ i+ +E+++
    EFC39820.1  47 NNNNlnnninNNNNLNNNNNLNNNNNNTEQVLYHLFNTFDINKDNSITFDELLHMRRSMSKFQNLnenqllneTRIIFDQLDTDKNGIIDFNEFVH 142
                   33333334423333444555666677777788889**********************998876541111222255688999***********9975 PP

>> PolC_DP2  DNA polymerase II large subunit DP2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.7   7.9e-06     0.013     461     539 ..      35     114 ..      27     143 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 7.9e-06
    PolC_DP2 461 kytylwhdisveelekLaeavaekkkleeeklvleleeevkeiLekllvehkvkee.kivieealallkslgldleeekl 539
                 ++ ++++++++++ ++L++ ++++++l++++   +++++++++L +l+ +++++++ +i+ +e l + +s++  ++ ++ 
  EFC39820.1  35 AFLMFYNQLNNNNNNNLNNNINNNNNLNNNNNLNNNNNNTEQVLYHLFNTFDINKDnSITFDELLHMRRSMSKFQNLNEN 114
                 5889*********************999888889999999***********99765156669999999999874443333 PP

>> Vps23_core  Vps23 core domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.9   0.0      0.97   1.6e+03      35      45 ..      23      33 ..      16      34 .. 0.85
   2 ?    9.4   0.0   0.00062         1      20      55 ..      71     109 ..      62     112 .. 0.86
   3 ?    0.7   0.0      0.32   5.3e+02      35      46 ..     131     142 ..     114     146 .. 0.84

  Alignments for each domain:
  == domain 1  score: -0.9 bits;  conditional E-value: 0.97
  Vps23_core 35 drgkidldtfl 45
                ++gkid+ +f+
  EFC39820.1 23 HSGKIDFREFV 33
                689****9997 PP

  == domain 2  score: 9.4 bits;  conditional E-value: 0.00062
  Vps23_core  20 dkAieDtiylLdkald...rgkidldtflKqvReLareq 55 
                 ++  e ++y+L + +d   +++i++d+ l + R++++ q
  EFC39820.1  71 NNNTEQVLYHLFNTFDinkDNSITFDELLHMRRSMSKFQ 109
                 667899*********6666****************9866 PP

  == domain 3  score: 0.7 bits;  conditional E-value: 0.32
  Vps23_core  35 drgkidldtflK 46 
                 ++g id+++f+ 
  EFC39820.1 131 KNGIIDFNEFVH 142
                 58999**99985 PP

>> EF-hand_9  EF-hand domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0    0.0088        14       2      18 ..      14      30 ..      13      49 .. 0.85
   2 ?    1.4   0.0      0.25   4.1e+02      36      60 ..      77     100 ..      67     110 .. 0.61
   3 ?    2.0   0.0      0.17   2.7e+02       3      19 ..     123     139 ..     121     146 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.0088
   EF-hand_9  2 tvFevcDtqktGrVpvs 18
                  F+++Dt+  G++   
  EFC39820.1 14 NHFNLFDTDHSGKIDFR 30
                56***********9765 PP

  == domain 2  score: 1.4 bits;  conditional E-value: 0.25
   EF-hand_9  36 eLeelakelDPdgedasvdldtflr 60 
                  L  l + +D +  d+s+ +d  l+
  EFC39820.1  77 VLYHLFNTFDINK-DNSITFDELLH 100
                 5555666666443.46666666544 PP

  == domain 3  score: 2.0 bits;  conditional E-value: 0.17
   EF-hand_9   3 vFevcDtqktGrVpvsr 19 
                 +F+  Dt+k G +   +
  EFC39820.1 123 IFDQLDTDKNGIIDFNE 139
                 69999999999997655 PP

>> Caleosin  Caleosin related protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.3   0.3     0.005       8.2       5      31 ..      11      37 ..       7      46 .. 0.85
   2 ?    7.4   0.3    0.0023       3.7      72     125 ..      55     108 ..      49     116 .. 0.81
   3 ?    0.9   0.1      0.24   3.9e+02      14      31 ..     128     145 ..     121     148 .. 0.81

  Alignments for each domain:
  == domain 1  score: 6.3 bits;  conditional E-value: 0.005
    Caleosin  5 vLqqHvaFfDrdkdGiiypldtyrgfr 31
                 +++H++ fD+d+ G i + +   +f 
  EFC39820.1 11 FIENHFNLFDTDHSGKIDFREFVVAFL 37
                5789*************9999888775 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0023
    Caleosin  72 ihkakhgSdsgaYdeeGrfvpqkfeeifskyakekkdaltlkevlellkgqrea 125
                 i++++   + +  +++ + ++q + ++f+ ++ +k++++t++e+l++ ++  + 
  EFC39820.1  55 INNNNNLNNNNNLNNNNNNTEQVLYHLFNTFDINKDNSITFDELLHMRRSMSKF 108
                 55556666666777778888999999********************99876655 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.24
    Caleosin  14 DrdkdGiiypldtyrgfr 31 
                 D+dk+Gii + +  ++f+
  EFC39820.1 128 DTDKNGIIDFNEFVHAFK 145
                 899999999998888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1980  (0.110436); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.53u 0.31s 00:00:00.84 Elapsed: 00:00:00.49
# Mc/sec: 920.57
//
Query:       EFC39821.1  [L=228]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.015   15.6   2.8      0.015   15.6   2.8    2.4  3  DUF4061   Domain of unknown function (DUF4061)
      0.025   14.8   3.0      0.025   14.8   3.0    3.7  4  KxDL      Uncharacterized conserved protein
        2.5    8.0  15.8        1.4    8.9   5.6    2.5  2  IL2       Interleukin 2


Domain annotation for each model (and alignments):
>> DUF4061  Domain of unknown function (DUF4061)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   2.4       1.2   7.5e+03      80      80 ..      53      53 ..      15      88 .. 0.56
   2 ?   -1.4   0.6      0.51     3e+03      78      78 ..      80      80 ..      53     112 .. 0.57
   3 ?   15.6   2.8   2.6e-06     0.015       7      87 ..     120     211 ..     114     212 .. 0.73

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.2
     DUF4061 80 L 80
                +
  EFC39821.1 53 M 53
                0 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.51
     DUF4061 78 s 78
                +
  EFC39821.1 80 N 80
                2 PP

  == domain 3  score: 15.6 bits;  conditional E-value: 2.6e-06
     DUF4061   7 eegLlklledFhsGklkafGkdc....sleqleeiReqQekLarlhfeldaeeeelaekeedalr.......esdenlkkLvskLeqLsksI 87 
                 ee L ++ + F  G ++afG ++    +l+ +++i   Q +     +e++ ++++l +++ d+++       e+++ +++Lv++L+ ++ sI
  EFC39821.1 120 EEELKSIDQTFSIGAMNAFGMKQseneILNLIDQISTLQVRSFLGSMEIELKHQNLLNNNFDNFQsvsqlfqEKEKSISNLVKDLKIITRSI 211
                 788999999***********999444445556666666766555555666666655555555555666777799999**********99999 PP

>> KxDL  Uncharacterized conserved protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.6   1.4      0.11   6.8e+02      17      31 ..      15      29 ..       2      50 .. 0.82
   2 ?   -2.1   1.1       0.8   4.8e+03      12      26 ..      64      78 ..      45      97 .. 0.68
   3 ?    1.6   0.1     0.055   3.3e+02      35      72 ..     115     152 ..      98     162 .. 0.73
   4 ?   14.8   3.0   4.2e-06     0.025      40      80 ..     180     220 ..     151     224 .. 0.81

  Alignments for each domain:
  == domain 1  score: 0.6 bits;  conditional E-value: 0.11
        KxDL 17 lQaqtsgrlnkknre 31
                +Q q+s  ln++n  
  EFC39821.1 15 QQPQLSSSLNNTNTN 29
                799*********976 PP

  == domain 2  score: -2.1 bits;  conditional E-value: 0.8
        KxDL 12 deilalQaqtsgrln 26
                ++  ++Q+q s+ l 
  EFC39821.1 64 NSPQQQQQQQSNNLL 78
                555555555555553 PP

  == domain 3  score: 1.6 bits;  conditional E-value: 0.055
        KxDL  35 lnalsqerlaklrarfkqgtkllkevkkdLesifkkir 72 
                 ++ +s+e+l+++ + f  g+  +  +k+  + i   i+
  EFC39821.1 115 VIGFSEEELKSIDQTFSIGAMNAFGMKQSENEILNLID 152
                 46789999999999999999998888876555555555 PP

  == domain 4  score: 14.8 bits;  conditional E-value: 4.2e-06
        KxDL  40 qerlaklrarfkqgtkllkevkkdLesifkkirslkaklak 80 
                    ++++++ f+++ k ++++ kdL+ i++ i+ +++k+ +
  EFC39821.1 180 FDNFQSVSQLFQEKEKSISNLVKDLKIITRSINDINQKIHQ 220
                 3579999*******************************987 PP

>> IL2  Interleukin 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.9   5.6   0.00023       1.4      14     110 ..      60     156 ..      36     165 .. 0.83
   2 ?    5.8   1.4     0.002        12      62     110 ..     165     210 ..     155     227 .. 0.63

  Alignments for each domain:
  == domain 1  score: 8.9 bits;  conditional E-value: 0.00023
                 XXXXXXXXXXXXXHHHHHHHHHHHHHHHH.HHBTT--HHHHTCEEEE-BSS--SGGGHHHHHHTHHHHHHHHHHHHHHSS--TTHHHHHHHHHHHHHH CS
         IL2  14 saPtssstketqqqleqllldlqlllekv.knyknlklsrmltfklylPkkatelkhlqcleeelkpleevlnlaqsknfeledikelisninvtvlk 110
                 s+P  s ++++qqq ++ll +  ll +   + ++n+++++  t++    ++  +++ +   eeelk++++ +++     f +++ ++ i n+   +  
  EFC39821.1  60 SSPLNSPQQQQQQQSNNLLTNN-LLQQSFqSPNNNSTINNNSTINSSNNNNLNNFDVIGFSEEELKSIDQTFSIGAMNAFGMKQSENEILNLIDQIST 156
                 7899999999999999999873.34444403456788889999999999999999999999********************99999998887555554 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.002
                 SS--SGGGHHHHHHTHHHHHHHHHHHHHHSS--TTHHHHHHHHHHHHHH CS
         IL2  62 kkatelkhlqcleeelkpleevlnlaqsknfeledikelisninvtvlk 110
                  +  elkh + l++++  +++v +l q+k+ +++   +l+++++++  +
  EFC39821.1 165 SMEIELKHQNLLNNNFDNFQSVSQLFQEKEKSIS---NLVKDLKIITRS 210
                 5667889999999999999999988888865543...333333333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (228 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2382  (0.132857); expected 358.6 (0.02)
Passed bias filter:                      322  (0.0179597); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.60u 0.35s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 1283.36
//
Query:       EFC39822.1  [L=161]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      8e-15   54.2   1.1    2.9e-14   52.4   1.2    1.9  2  PC4            Transcriptional Coactivator p15 (PC4)
    4.5e-13   48.9   5.4      1e-12   47.8   5.4    1.6  1  DEK_C          DEK C terminal domain
  ------ inclusion threshold ------
      0.028   14.2   0.5      0.032   13.9   0.5    1.1  1  Cytochrom_C1   Cytochrome C1 family
      0.039   14.2  12.1      0.052   13.8  12.1    1.1  1  MPM1           Mitochondrial peculiar membrane protein 1
      0.058   11.2   5.9      0.058   11.2   5.9    1.0  1  PI3K_1B_p101   Phosphoinositide 3-kinase gamma adapter protei
       0.11   12.3   3.4       0.11   12.3   3.4    1.1  1  MID_MedPIWI    MID domain of medPIWI
       0.13   12.2   0.2       0.16   11.8   0.2    1.2  1  DUF3323        Protein of unknown function N-terminus (DUF332
       0.14   12.2   1.4       0.21   11.6   0.4    1.8  2  Peptidase_S24  Peptidase S24-like
       0.21   12.0   4.4       0.26   11.6   4.4    1.4  1  AIF_C          Apoptosis-inducing factor, mitochondrion-assoc
       0.22   11.6   2.5       0.24   11.5   2.5    1.2  1  RP-C_C         Replication protein C C-terminal region
        0.3    9.3  10.3       0.31    9.3  10.3    1.0  1  CDC45          CDC45-like protein
        1.3    8.1   3.1        1.3    8.2   3.1    1.1  1  Zip            ZIP Zinc transporter
        1.3    7.7   4.6        1.3    7.7   4.6    1.1  1  Presenilin     Presenilin
        1.6    7.5   9.3        1.7    7.4   9.3    1.0  1  ALMT           Aluminium activated malate transporter
        3.4    8.8   5.4        8.4    7.5   5.4    2.1  1  DUF3298        Protein of unknown function (DUF3298)
        6.6    6.9   8.8         21    5.3   8.7    1.9  1  DUF4530        Domain of unknown function (DUF4530)


Domain annotation for each model (and alignments):
>> PC4  Transcriptional Coactivator p15 (PC4)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       2.4   2.6e+03      22      34 ..      31      44 ..      28      47 .. 0.63
   2 !   52.4   1.2   2.6e-17   2.9e-14       5      50 ..     108     149 ..     106     151 .. 0.94

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 2.4
                EEEEEECT.TEEEE CS
         PC4 22 IReyyekd.gelkP 34
                IRe  ekd g  + 
  EFC39822.1 31 IREALEKDlGVSLS 44
                77777776565554 PP

  == domain 2  score: 52.4 bits;  conditional E-value: 2.6e-17
                 CCEEEEEEEETTEEEEEEEEEEECTTEEEEEEEEEEEEHHHHHHHH CS
         PC4   5 kkrrvtvrefkGktlvdIReyyekdgelkPgkKGIsLtleqweaLk 50 
                  k+r+tv+efk +++v IReyye+    kP+kKG++++ ++w  +k
  EFC39822.1 108 DKKRITVNEFKKSKYVHIREYYED----KPTKKGVAMSRDEWTRFK 149
                 79*********************5....**************9998 PP

>> DEK_C  DEK C terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.8   5.4   8.9e-16     1e-12       2      53 ..       5      57 ..       4      58 .. 0.94

  Alignments for each domain:
  == domain 1  score: 47.8 bits;  conditional E-value: 8.9e-16
       DEK_C  2 sdeeirkaireiLrea.DLdtvTkkkvReqLeeklgvdLsekKafIkalIdei 53
                +++ +rk++ +iL+++ D dtv+ k++Re+Le+ lgv Ls++K+ +k +I+e+
  EFC39822.1  5 DEKILRKKVAAILKSQsDDDTVSLKTIREALEKDLGVSLSSQKDVLKTIIKEE 57
                68889**********88*********************************987 PP

>> Cytochrom_C1  Cytochrome C1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.5   2.9e-05     0.032      43     130 ..      43     136 ..      24     159 .. 0.80

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.9e-05
  Cytochrom_C1  43 lglteeevkalaaeyevkdgpddegemfeRpgkpaDklpspyaneeaaraanggalppDLsllvkArk.......ggadYiyslLtgYeeppagv 130
                   l  +++ +k++ +e   k+++++e+e ++R+ + +D+  +p + ++++  + ++a   DL +    +k       + ++Y++ + + Ye++p++ 
    EFC39822.1  43 LSSQKDVLKTIIKEEMNKNQEEEEEESNKRKHNDSDNEDEPSEKKQKSSHKITKADNGDLVVFFTDKKritvnefKKSKYVH-IREYYEDKPTKK 136
                   44556668999999999999999**************************************999998888999888888987.556667777644 PP

>> MPM1  Mitochondrial peculiar membrane protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8  12.1   4.6e-05     0.052      33     159 ..       7     133 ..       4     140 .. 0.68

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 4.6e-05
        MPM1  33 sevpeellkkkkkklkdeiltkEdvendkkhkyGlFFkeftdyLn..Wksemkelikekreeeikkkkeeekkkkesektkedlmlkkssekdskkkvv 129
                 + +++++++  k++++d+ ++   + ++ ++  G+  ++ +d L+   k+em+++++e++ee+ k+k+ ++++++++ ++k++ + +k +++d++  vv
  EFC39822.1   7 KILRKKVAAILKSQSDDDTVSLKTIREALEKDLGVSLSSQKDVLKtiIKEEMNKNQEEEEEESNKRKH-NDSDNEDEPSEKKQKSSHKITKADNGDLVV 104
                 5667888888899999****************************844477777766555554444433.333333333333444444444445566666 PP

        MPM1 130 ssssktsvntteegneeklkevktyfddgt 159
                     k +++ + e ++ k+ ++++y++d  
  EFC39822.1 105 FFTDKKRITVN-EFKKSKYVHIREYYEDKP 133
                 66666666555.555599********9975 PP

>> PI3K_1B_p101  Phosphoinositide 3-kinase gamma adapter protein p101 subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   5.9   5.2e-05     0.058     260     342 ..      14      95 ..       2     144 .. 0.78

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 5.2e-05
  PI3K_1B_p101 260 lelpassgkksegklqtlelpvakcytysWekdnfDvLneilekeselaspeeledeeeedeedvdeeedleeeeeeeeedsl 342
                   +++ +s++++++ +l+t++ +  k   +s +++  DvL++i+++e+++++ ee+e++++ +++d d+e++ +e++++++++++
    EFC39822.1  14 AAILKSQSDDDTVSLKTIREALEKDLGVSLSSQ-KDVLKTIIKEEMNKNQEEEEEESNKRKHNDSDNEDEPSEKKQKSSHKIT 95 
                   456667788888889999999999888888765.5*************99999999988888889999998888887776555 PP

>> MID_MedPIWI  MID domain of medPIWI
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   3.4   9.9e-05      0.11      59     146 ..       7      90 ..       1     136 [. 0.56

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 9.9e-05
  MID_MedPIWI  59 klseepvsdwflkssnselssklklyaqvckhklapylss.......llsnpkssssttsassssssssssssssssssaqksqeesestkerek 146
                  k   ++v+ ++++ ++ + +  lk  +++++++l+ +lss       +           +++ ++++++++++s++ +++++++e++ s+k++++
   EFC39822.1   7 KILRKKVAAILKS-QSDDDTVSLKTIREALEKDLGVSLSSqkdvlktI----------IKEEMNKNQEEEEEESNKRKHNDSDNEDEPSEKKQKS 90 
                  5556666666666.445666789*****************44432111..........1111111111111111111111111111111111111 PP

>> DUF3323  Protein of unknown function N-terminus (DUF3323)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.2   0.00015      0.16      28      81 ..      20      74 ..       4     104 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 0.00015
     DUF3323 28 pgesvrvsladldaalrk.srfarsdleevlealfgeplltrkeeraaeaeawaa 81
                +++  +vsl+++ +al+k  +++ s+ ++vl+ +++e+++ ++ee+++e +++++
  EFC39822.1 20 QSDDDTVSLKTIREALEKdLGVSLSSQKDVLKTIIKEEMNKNQEEEEEESNKRKH 74
                567789*******999762799********************9999999999876 PP

>> Peptidase_S24  Peptidase S24-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       2.5   2.8e+03      41      51 ..      48      58 ..      22      80 .. 0.64
   2 ?   11.6   0.4   0.00019      0.21      21      55 ..      93     126 ..      85     135 .. 0.82

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 2.5
                   EEEEEEEEETT CS
  Peptidase_S24 41 ayiKrviglpg 51
                   +  K +i+++ 
     EFC39822.1 48 DVLKTIIKEEM 58
                   44555554443 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 0.00019
                    CTS---TTSEEEEEETTCE-EEEEEEEEETTEEEE CS
  Peptidase_S24  21 kfsepkrGdivvfrlpgeeeayiKrviglpgdrvl 55 
                    k +++++Gd+vvf +++++ +++ ++++ +  +++
     EFC39822.1  93 KITKADNGDLVVFFTDKKR-ITVNEFKKSKYVHIR 126
                    6789**************8.999999987766666 PP

>> AIF_C  Apoptosis-inducing factor, mitochondrion-associated, C-term
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   4.4   0.00024      0.26      48     110 ..      45     112 ..      14     131 .. 0.69

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00024
       AIF_C  48 tekdtpkaaveesseesksekeeeaskekseeks.....eeekkkkekkeeeedygkGvvfylrddkv 110
                 ++kd  k++++e+ +++++e+eee++k k+++++     +e+k+k+++k ++ d g  vvf+  ++++
  EFC39822.1  45 SQKDVLKTIIKEEMNKNQEEEEEESNKRKHNDSDnedepSEKKQKSSHKITKADNGDLVVFFTDKKRI 112
                 56666666655544444444444443333333332333345566666677777888889999877765 PP

>> RP-C_C  Replication protein C C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   2.5   0.00021      0.24      35      85 ..      27      92 ..       2     156 .. 0.52

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00021
      RP-C_C 35 lreevenalesalkaenssanes...........qnerhiqnsnp....dsssesepasekereek 85
                  +++++ale+ l ++ ss ++            ++e++ ++sn+    ds++e ep+ +k++++ 
  EFC39822.1 27 SLKTIREALEKDLGVSLSSQKDVlktiikeemnkNQEEEEEESNKrkhnDSDNEDEPSEKKQKSSH 92
                333444444333333333333331111111111111111122222111123333333333332222 PP

>> CDC45  CDC45-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3  10.3   0.00027      0.31     108     181 ..      22     107 ..       9     159 .. 0.52

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00027
       CDC45 108 DDgdieeeleeereayealeeeeesdeede.....eeeeeddddeeeeeeeeedeedeeedeeeskkkrksksdeeee.........s 181
                 DD ++  +l++ rea e+    + s+++d      +ee +++++eeeee+++++++d+++++e s+kk+ks+++ +++         +
  EFC39822.1  22 DDDTV--SLKTIREALEKDLGVSLSSQKDVlktiiKEEMNKNQEEEEEESNKRKHNDSDNEDEPSEKKQKSSHKITKAdngdlvvffT 107
                 55554..777778888877777777644446677644433333333343433334343333333344444333322221122233331 PP

>> Zip  ZIP Zinc transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2   3.1    0.0011       1.3     121     169 ..      47      96 ..      13     145 .. 0.61

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.0011
         Zip 121 saakksvsndkveeseekedhvaeadtdadskee.lrngkqeksesekeq 169
                 +++ k++ ++++++++e e++++++++++ds+ e +  +k++ks+++ ++
  EFC39822.1  47 KDVLKTIIKEEMNKNQEEEEEESNKRKHNDSDNEdEPSEKKQKSSHKITK 96 
                 44444444455544444444444433333333220233333333333332 PP

>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   4.6    0.0012       1.3     284     320 ..      57      93 ..       5     145 .. 0.49

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0012
  Presenilin 284 ssaeesseekeseessesseeeeeeeeeeeeseseer 320
                 + +++++ee+e++++++++++++e+e +e++++s ++
  EFC39822.1  57 EMNKNQEEEEEESNKRKHNDSDNEDEPSEKKQKSSHK 93 
                 1111111111111111111111111111111111111 PP

>> ALMT  Aluminium activated malate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   9.3    0.0015       1.7     307     397 ..       6      95 ..       1     150 [. 0.48

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.0015
        ALMT 307 akvlrelaesvkkmkklskveellkevkvaae.eLqskldskskLlvnsekweaakkkekaeeveekkeeekeseskkeeaeaveeaesese 397
                  k+lr++  ++ k +     + +lk+++ a+e +L  +l s+  +l    k+e++k++e++ee+++k ++++++++++ ++ ++++++++ +
  EFC39822.1   6 EKILRKKVAAILKSQSDDD-TVSLKTIREALEkDLGVSLSSQKDVLKTIIKEEMNKNQEEEEEESNKRKHNDSDNEDEPSE-KKQKSSHKIT 95 
                 5677777777766666666.5778888888753588888666654433333333333333333333333332222222222.1111111111 PP

>> DUF3298  Protein of unknown function (DUF3298)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   5.4    0.0075       8.4       8      51 ..      44      93 ..       4     155 .. 0.78

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0075
                T.HHHHHHHHHHHHHHHHTCH-TTS-HCCCCTT......TTTSS-TTTSS CS
     DUF3298  8 saylqrlakiikeqikkenekqqedeyaglper......rdkedilgyqn 51
                s ++++l+ iike+++k++e+++e++ +   ++      + +++++ +  
  EFC39822.1 44 SSQKDVLKTIIKEEMNKNQEEEEEESNKRKHNDsdnedePSEKKQKSSHK 93
                56789999999999988886666555544444476666633333333333 PP

>> DUF4530  Domain of unknown function (DUF4530)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   8.7     0.019        21      74     110 ..      38      72 ..      28      93 .. 0.77

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.019
     DUF4530  74 slglemgalreelvtileeeeeeeeeeeeeeeeepee 110
                 +lg+ + + ++ l ti+ ee ++++eeeeee+++  +
  EFC39822.1  38 DLGVSLSSQKDVLKTIIKEEMNKNQEEEEEESNK--R 72 
                 6788888888888899888888877777764443..2 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (161 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3389  (0.189023); expected 358.6 (0.02)
Passed bias filter:                      981  (0.0547158); expected 358.6 (0.02)
Passed Vit filter:                       176  (0.0098165); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              16  [number of targets reported over threshold]
# CPU time: 0.64u 0.33s 00:00:00.97 Elapsed: 00:00:00.51
# Mc/sec: 950.64
//
Query:       EFC39823.1  [L=306]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.8e-25   89.1   0.0    4.3e-25   88.5   0.0    1.3  1  NAD_binding_1  Oxidoreductase NAD-binding domain
    2.9e-23   82.1   0.0      7e-23   80.9   0.0    1.7  1  FAD_binding_6  Oxidoreductase FAD-binding domain
    4.7e-07   30.0   0.0    1.1e-05   25.6   0.0    2.1  2  NAD_binding_6  Ferric reductase NAD binding domain


Domain annotation for each model (and alignments):
>> NAD_binding_1  Oxidoreductase NAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.5   0.0   7.3e-29   4.3e-25       1     106 [.     164     275 ..     164     278 .. 0.90

  Alignments for each domain:
  == domain 1  score: 88.5 bits;  conditional E-value: 7.3e-29
                    EEEEGGGGHHHHHHHHHHHHH.CTTCSEEEEEEEESSGCGSTTHHHHHHHHHHCTTEEEEEEE....ESSCTTTSSSEESSHHHHHHHHHHH.HSS CS
  NAD_binding_1   1 miagGtGiaPvrsvlrailee.akdktkvvlvyGnrteedllyreeleelakklpgrlkvvav....vsreeagweggkgrvqdalleells.lkk 90 
                    +i gGtGi+P +++++++l + ++dktk++l+y+ rt ed+l+++el++lakk+p+++k++++     +++++++ +g+g+v+++++e++    ++
     EFC39823.1 164 FIVGGTGITPAYQIIQRVLSQtNEDKTKLTLLYASRTPEDILLKKELDTLAKKYPQQFKIYYTvdsdPNQKADSSIQGRGFVNKEMIEKAGIpKPS 259
                    799******************888***************************************876555555566689**********98777899 PP

                    TTEEEEEECSHHHHHH CS
  NAD_binding_1  91 eethvyvCGppgMika 106
                    e+++v vCGp ++ ++
     EFC39823.1 260 EDVLVSVCGPMPFYDM 275
                    **********998776 PP

>> FAD_binding_6  Oxidoreductase FAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   80.9   0.0   1.2e-26     7e-23       3      99 .]      51     154 ..      49     154 .. 0.92

  Alignments for each domain:
  == domain 1  score: 80.9 bits;  conditional E-value: 1.2e-26
                    EEEEEEECCTTEEEEEEEESTTTS.......-----TT-EEEEEECETTCCEEEEEE.BSSTTECCEEEEEEE--TT-HHHHHHHCS-TT-EEEEE CS
  FAD_binding_6   3 kltekeevsedtrifrfklpsekq.......klglpvGqhvflrlkikgeaviRsYtpissenekGelellvkvypgGkmsqaLdelkigdtleik 91 
                    kl+e + +s+dt+i++f+l++ k+       k++ pv++ +++++++ +e v+R+Ytpi+++++ G++ellvk yp Gk+s+++++l++gd++e+k
     EFC39823.1  51 KLKEITPLSHDTSIYTFALEDTKEdnltvpyKMNVPVASCIVAKAQVADEVVVRPYTPINKSDDVGKMELLVKSYPTGKLSKHFSQLAVGDQIEFK 146
                    7999***************9887644444445899************************************************************* PP

                    EEE-SEEC CS
  FAD_binding_6  92 GPlGkfeY 99 
                    GP+ k+ Y
     EFC39823.1 147 GPFVKIDY 154
                    ***99887 PP

>> NAD_binding_6  Ferric reductase NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.0   1.9e-09   1.1e-05       4      89 ..     162     240 ..     159     249 .. 0.86
   2 ?    2.2   0.0      0.03   1.8e+02     124     149 ..     249     274 ..     245     278 .. 0.77

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 1.9e-09
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6   4 vllvagGiGitpfisilkdllkkskkealktkkikliwvvressslewfkdvLneleeeksegnieihiYlTseyeaedasdqlis 89 
                    + ++ gG+Gitp++ i++ +l +++    +++k++l  + r  +++ + k  L++l+++ ++   + +iY+T +++ +++ d++i+
     EFC39823.1 162 MAFIVGGTGITPAYQIIQRVLSQTN---EDKTKLTLLYASRTPEDILLKK-ELDTLAKKYPQ---QFKIYYTVDSDPNQKADSSIQ 240
                    67899****************9997...88999************96555.77777777777...99*********9999998886 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.03
                    xxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6 124 vlkdiaskhknssvgvfvCGppklvk 149
                    +++++   ++++ v v vCGp  + +
     EFC39823.1 249 MIEKAGIPKPSEDVLVSVCGPMPFYD 274
                    5666666789999********87766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (306 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       556  (0.0310112); expected 358.6 (0.02)
Passed bias filter:                      463  (0.0258241); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.32s 00:00:00.93 Elapsed: 00:00:00.54
# Mc/sec: 1701.15
//
Query:       EFC39824.1  [L=567]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    7.4e-06   25.4   0.1    2.1e-05   23.9   0.0    1.7  1  LCAT           Lecithin:cholesterol acyltransferase
    0.00076   19.1   0.1      0.025   14.1   0.0    2.4  2  DUF676         Putative serine esterase (DUF676)
     0.0037   16.4   0.0     0.0091   15.1   0.0    1.7  2  DUF1749        Protein of unknown function (DUF1749)
     0.0059   16.2   0.0      0.018   14.6   0.0    1.8  1  DUF2974        Protein of unknown function (DUF2974)
  ------ inclusion threshold ------
      0.015   15.1   0.0      0.035   13.8   0.0    1.6  1  PGAP1          PGAP1-like protein
      0.055   12.9   3.2       0.14   11.6   3.2    1.6  1  Nop            snoRNA binding domain, fibrillarin
      0.089   12.4   0.0        1.5    8.4   0.0    2.2  2  Abhydrolase_1  alpha/beta hydrolase fold
       0.53   10.1   4.9       0.22   11.3   1.1    2.2  2  partial_CstF   Partial cleavage stimulation factor domain
       0.76    9.5   8.1       0.35   10.6   5.0    2.0  2  RMI1_N         RecQ mediated genome instability protein
        3.7    7.6   5.7          7    6.7   5.7    1.4  1  RP-C_C         Replication protein C C-terminal region
        7.7    5.8   7.3         14    4.9   7.3    1.3  1  DUF4820        Domain of unknown function (DUF4820)


Domain annotation for each model (and alignments):
>> LCAT  Lecithin:cholesterol acyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.9   0.0   1.3e-08   2.1e-05     114     177 ..     374     435 ..     352     446 .. 0.86

  Alignments for each domain:
  == domain 1  score: 23.9 bits;  conditional E-value: 1.3e-08
        LCAT 114 ealklsgkkvvliaHSmGnllvlyflkwveaeaWvdqhikafislgapllGsvkavkallsGen 177
                 e+  + ++k ++i+HS G+  + y l ++e+e    +++k+ isl ap++Gs  a   +  G  
  EFC39824.1 374 ETSSEMNQKLLVIGHSKGACDITYALAKYENEL--KPYVKGLISLQAPYAGSALANDITEFGAA 435
                 44557899*********************9999..9****************999888888876 PP

>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0     0.082   1.3e+02      48      77 ..     294     323 ..     289     330 .. 0.87
   2 !   14.1   0.0   1.5e-05     0.025      72     135 ..     373     429 ..     333     451 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.082
      DUF676  48 nesktfkgidvlgerlaeevlevvkkkkdk 77 
                 ++ +t+kg++  +e l +e++e++++ ++ 
  EFC39824.1 294 SQVDTGKGVESNAEFLKNEIIEYFNELNNI 323
                 5779********************998876 PP

  == domain 2  score: 14.1 bits;  conditional E-value: 1.5e-05
      DUF676  72 kkkkdk.nkkiSfvghSlGgliaraaiaklkekemtlkeaikglepvtfitlasPhLGvlyssks 135
                 k+ +++ n+k+ ++ghS G   +++a+ak +++ +  +      ++  +i+l  P+ G++  +  
  EFC39824.1 373 KETSSEmNQKLLVIGHSKGACDITYALAKYENELK--P------YVKGLISLQAPYAGSALANDI 429
                 333333699*******************9886665..3......56678*******999987766 PP

>> DUF1749  Protein of unknown function (DUF1749)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0       3.6   5.8e+03      29      39 ..     258     268 ..     238     273 .. 0.67
   2 !   15.1   0.0   5.6e-06    0.0091      96     144 ..     373     421 ..     355     470 .. 0.83

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 3.6
     DUF1749  29 kskallFigGL 39 
                 + + +lF+gGL
  EFC39824.1 258 NIRGILFVGGL 268
                 56789*****9 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 5.6e-06
     DUF1749  96 ktksGeekkekvvlmGHstGsqdvlyYltssnerdrekvdgai.lqapvs 144
                 k+ + +e ++k++++GHs G+ d+ y l + +++ +++v+g i lqap +
  EFC39824.1 373 KE-TSSEMNQKLLVIGHSKGACDITYALAKYENELKPYVKGLIsLQAPYA 421
                 33.3467899**************99999999999*******97899965 PP

>> DUF2974  Protein of unknown function (DUF2974)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.0   1.1e-05     0.018      78     122 ..     375     419 ..     366     437 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 1.1e-05
     DUF2974  78 ileesegkiylgGhSkGGnlAvyaamnaeddlqeriskiysfDgp 122
                   +e+++k+++ GhSkG+   +ya+++ e++l+  ++  +s+ +p
  EFC39824.1 375 TSSEMNQKLLVIGHSKGACDITYALAKYENELKPYVKGLISLQAP 419
                 55788999****************************999998877 PP

>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0   2.2e-05     0.035      41     139 ..     336     430 ..     294     438 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.2e-05
       PGAP1  41 qnkkeldfftvdfneelsaldGrtlldqaeylndaIkyIlslysssekeptsviliGHSmGGi.varaaltlknyikqsvntiltlasPhalpplsfdk 138
                 + +++ +  t+++n++   ++    +d  +   ++I+   +  ++s++ ++++++iGHS G   +  a+++++n  k  v+ +++l +P a + l++d 
  EFC39824.1 336 NEQQQQQHSTINTNNNSNNNNNDNNNDNNN---NMINS--EEKETSSEMNQKLLVIGHSKGACdITYALAKYENELKPYVKGLISLQAPYAGSALANDI 429
                 444445666666666666665555444333...33444..23356788899**********876999999*************************9995 PP

       PGAP1 139 d 139
                 +
  EFC39824.1 430 T 430
                 4 PP

>> Nop  snoRNA binding domain, fibrillarin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   3.2   8.6e-05      0.14      10     118 ..     303     419 ..     295     430 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 8.6e-05
                 HHHHHHHHHHHTTTSTCHHHHS-SHHHHHHHHHHCCC........CHCCT.HHTT........HHHHHHHHHHHHCHHHH-SSS-S-HHHHHHHHHHHH CS
         Nop  10 ntlhkrvrewYswhFpELeslvkdnleYakvvklign........eredlekkee.......deelakevimaakvtastsmgaelseedlknikelcd 93 
                 ++ ++++++   ++F EL+++ ++ ++  +  +  ++        ++       +       d++ +++  m+ + + +ts++++ +   + + k +cd
  EFC39824.1 303 ESNAEFLKNEIIEYFNELNNITTSRVNENNENNNEQQqqqhstinTN-------NnsnnnnnDNNNDNNNNMINSEEKETSSEMNQKLLVIGHSKGACD 394
                 55667777777788888888877765443333222221111211111.......0223333344466666677777678899999999999******** PP

                 HHHHHHHHHHHHHHHHHHHHHHHSH CS
         Nop  94 rvleleelrkelleYlesrmsaiAP 118
                  +  l+++ +el+ Y++  +s  AP
  EFC39824.1 395 ITYALAKYENELKPYVKGLISLQAP 419
                 ********************99999 PP

>> Abhydrolase_1  alpha/beta hydrolase fold
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.1      0.12   1.9e+02     164     223 ..      30     120 ..      14     141 .. 0.70
   2 ?    8.4   0.0   0.00092       1.5      72     106 ..     380     418 ..     340     434 .. 0.86

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.12
                    HCHHHCCHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHC...........................THHHHSEEEEEEE.....TTCS CS
  Abhydrolase_1 164 pdkskrfpssgsdnasslatgalksieqwpttdsaklllrlre...........................lknvlaptlvisg.....tsDp 223
                    + +s +  ss+s+ +ss++ +++ +i  ++++++ ++  ++++                           +k+vl + lv ++     +sD+
     EFC39824.1  30 EPSSLSSSSSSSPSSSSSKLTSKDNIIIAADELFEQFSSNIQNsltlpikklvnlisksnnikfekieriIKKVLPNYLV-QSyspeqESDH 120
                    67788889999999999999999999999999999999999887666666555555555555555555555555533333.22234444444 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.00092
                    TSSEEEEEETHHHHHHHHHHHHH....GGGEEEEEEESE CS
  Abhydrolase_1  72 ddkltlvGhSmGGmialayaaey....perVkalvllga 106
                    ++kl ++GhS G    ++++a+y    + +Vk+l++l a
     EFC39824.1 380 NQKLLVIGHSKGACDITYALAKYenelKPYVKGLISLQA 418
                    57999*******************************999 PP

>> partial_CstF  Partial cleavage stimulation factor domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.3   0.1       1.2   1.9e+03      13      27 ..      77      91 ..      68      99 .. 0.83
   2 ?   11.3   1.1   0.00013      0.22       8      49 ..     300     341 ..     293     344 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.3 bits;  conditional E-value: 1.2
  partial_CstF 13 aeeaLVdeViknkdi 27
                  + ++LV+ + k+++i
    EFC39824.1 77 PIKKLVNLISKSNNI 91
                  567999999999998 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 0.00013
  partial_CstF   8 sgvepaeeaLVdeViknkdiLqnilkskpedmtsWpsEqkqq 49 
                   +gve  +e L +e+i   + L+ni +s++++ ++ ++Eq+qq
    EFC39824.1 300 KGVESNAEFLKNEIIEYFNELNNITTSRVNENNENNNEQQQQ 341
                   8999************************************98 PP

>> RMI1_N  RecQ mediated genome instability protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   5.0   0.00021      0.35      63     140 ..     300     378 ..     280     407 .. 0.72
   2 ?   -2.7   0.0       2.4     4e+03     146     162 ..     439     456 ..     424     458 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00021
      RMI1_N  63 rksesspa.lkgpvvvQvldiedigsSaysqlealeavergeetrgrevirt.e.saaaasakadeenseekeeaqatsse 140
                 +  es+++ lk++++   +++ +i++S+++  ++ ++  ++++ ++ +++ + + +++++++++d++n+  ++e+++tsse
  EFC39824.1 300 KGVESNAEfLKNEIIEYFNELNNITTSRVNENNENNN--EQQQQQHSTINTNnNsNNNNNDNNNDNNNNMINSEEKETSSE 378
                 44444555799999999*************9999777..344444444444455566666777777777777777777632 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 2.4
      RMI1_N 146 mlkLeLtDg.gqkvkAiE 162
                 +lk++++D  g ++kAiE
  EFC39824.1 439 LLKILIEDVlGGELKAIE 456
                 578888888888888887 PP

>> RP-C_C  Replication protein C C-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   5.7    0.0043         7      34      96 ..     315     378 ..     294     413 .. 0.57

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0043
      RP-C_C  34 alreevenalesalkaenssanesqnerhiq.nsnpdsssesepasekereekeaaaasaeaep 96 
                 +  +e++n++ s+++++n++ ne+q+++h + n+n++s+++ + +++ ++++  ++++++++++
  EFC39824.1 315 EYFNELNNITTSRVNENNENNNEQQQQQHSTiNTNNNSNNNNNDNNNDNNNNMINSEEKETSSE 378
                 3445566666777777777777777777765244444444433333333333333333333322 PP

>> DUF4820  Domain of unknown function (DUF4820)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   7.3    0.0088        14     165     216 ..     328     383 ..     301     391 .. 0.55

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.0088
     DUF4820 165 artlterksekesae....sseskkrnkeerdaeseeessede...eeeetvkelleky 216
                 ++  +e+++e+++++    +++++++n+++ +++++++        ee+et +e+++k+
  EFC39824.1 328 VNENNENNNEQQQQQhstiNTNNNSNNNNNDNNNDNNNN---MinsEEKETSSEMNQKL 383
                 333333333333333000033333333333333333333...24458999999999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (567 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2774  (0.154721); expected 358.6 (0.02)
Passed bias filter:                      774  (0.0431703); expected 358.6 (0.02)
Passed Vit filter:                       153  (0.00853366); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.87u 0.36s 00:00:01.23 Elapsed: 00:00:00.52
# Mc/sec: 3301.05
//
Query:       EFC39825.1  [L=640]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.2e-28  100.2   2.7    1.2e-28  100.2   2.7    2.2  2  Pkinase         Protein kinase domain
      2e-20   73.2   0.8    3.4e-20   72.4   0.8    1.4  1  Pkinase_Tyr     Protein tyrosine kinase
    7.1e-06   25.6   0.3    7.1e-06   25.6   0.3    3.3  3  DUF4116         Domain of unknown function (DUF4116)
     0.0045   16.6   0.4     0.0045   16.6   0.4    2.1  2  RIO1            RIO1 family
  ------ inclusion threshold ------
      0.019   15.4   1.3       0.28   11.6   0.2    2.8  2  Telomere_reg-2  Telomere length regulation protein
      0.046   13.0   0.0      0.076   12.3   0.0    1.3  1  Kinase-like     Kinase-like


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.1      0.53   1.6e+03     184     222 ..     116     159 ..     110     194 .. 0.60
   2 !  100.2   2.7     4e-32   1.2e-28       5     222 ..     254     477 ..     251     616 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 0.53
                 HHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCT.....S CS
     Pkinase 184 Gvilyelltgkppfsgekgkekvekeldqlekilkilg.....e 222
                  ++ +++ + k  f++++++++v + +++ e+ + i +     +
  EFC39825.1 116 NCTTINMNNDKSFFHHRDDDDDVITCTEKNESNCTIEQkdhqgN 159
                 68889999999999988888888877777666666655332220 PP

  == domain 2  score: 100.2 bits;  conditional E-value: 4e-32
                 EEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH...HHSS--HHHH CS
     Pkinase   5 eklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle...rkgslseeea 100
                 ek+GeGsfG+V+++++ +++ +     +++ k+  + +   ++E    ++l hpn+v++ +++      ++ +ey+egg+la++++   +k ++ ++++
  EFC39825.1 254 EKIGEGSFGCVLRVTK-RNESTLKNEFVRVVKIIPNAT-MGVSEAVKGARLTHPNVVKVHHAMLIRYICCIEMEYIEGGSLANYIKfncKKFTIHKDTV 350
                 89*************5.555566666777777777664.67899999***************************************9999999****** PP

                 HHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH...TTSCB..SHHHHHHHHHHHHHHHHHSS CS
     Pkinase 101 kkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelessskltsfvgtseYlAPEvl...keney..skkvDvWslGvilyelltgk 194
                 k+++ q le l  + +++i+H D+Kp+Ni++ e+ ++ i+DFG++ + ++ s  ++  g+++Y+ P +    ++ e+  + ++D++slG+++ el++++
  EFC39825.1 351 KNMLFQCLEVLLLMKQHEIVHSDIKPDNIMVRESFDIAIGDFGVSLQNQTMS-SQTLGGSKRYMEPKLKanfNTDEFkpDFSTDLYSLGMTFEELIANS 448
                 *********************************************9998877.9*************998873344435899*************9988 PP

                 -STTTSSHHHHHHHHHHTHHHHHHHCT.S CS
     Pkinase 195 ppfsgekgkekvekeldqlekilkilg.e 222
                 p  ++ ++  +  k  d  ++i    +  
  EFC39825.1 449 PRNNKVHECIQGLKSKDSSQRIKACYEfA 477
                 87775555444444444444444444342 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.4   0.8   1.1e-23   3.4e-20       4     258 ..     253     508 ..     250     509 .. 0.74

  Alignments for each domain:
  == domain 1  score: 72.4 bits;  conditional E-value: 1.1e-23
                  EEEEEEESSEEEEEEEEET.TTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCTTTS CS
  Pkinase_Tyr   4 gkklGeGafGkVvegtlkg.ekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkekekl 100
                   +k+GeG+fG V + t ++ ++ k+e   +vK++ + ++       ++ea    +l hpn+vk++ +++ +   +i +ey++gG+L ++++ + k+ +
   EFC39825.1 253 AEKIGEGSFGCVLRVTKRNeSTLKNEFVRVVKIIPNATMG------VSEAVKGARLTHPNVVKVHHAMLIRYICCIEMEYIEGGSLANYIKFNCKKFT 344
                  589*************998444455555578888554444......5788888899*************999999****************9944433 PP

                  BHHH.HHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETT.SSTSGGGGS-HHHHHHSEEEHHHHHHHHHHHHH CS
  Pkinase_Tyr 101 tlkd.llsfalqvAkGmeyLeskklvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkke.eaklpvkWmapEslkekkftsksDvWsfGvllw 196
                    kd + ++ +q  + +  ++++++vH d+   N++++e+  + i+DfG++ + +++++++  + ++ +  k  a    +e k   ++D +s G++  
   EFC39825.1 345 IHKDtVKNMLFQCLEVLLLMKQHEIVHSDIKPDNIMVRESFDIAIGDFGVSLQNQTMSSQTLGGsKRYMEPKLKANFNTDEFKPDFSTDLYSLGMTFE 442
                  33441567999****************************************99966666654440445777788888888888999************ PP

                  HHHTTSSGTTTTSHHHHHHHHHHTTEES-BBTTSBHHHHHHH.......HHHT-SSGGGS--HHHHHHH CS
  Pkinase_Tyr 197 Eiftlgespypglkneevleklkegkrlekpekcpeelyelm.......kkcweedpeeRptfselvek 258
                  E++ ++ +     k +e+++ lk++   ++ + c e   e++       ++ w ++ e  p+++el+++
   EFC39825.1 443 ELIANSPRN---NKVHECIQGLKSKDSSQRIKACYEFASEIIvkenrnfNNIWFNEEEMKPHLRELRKQ 508
                  ***954443...344455555555555555555555444443111111156777777777777777766 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.1       4.5   1.3e+04      24      38 ..     132     146 ..     131     148 .. 0.80
   2 ?   -1.3   0.1      0.64   1.9e+03      15      28 ..     473     487 ..     461     489 .. 0.70
   3 !   25.6   0.3   2.4e-09   7.1e-06       2      40 ..     534     579 ..     533     602 .. 0.75

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 4.5
     DUF4116  24 knDkeivlkAvkqng 38 
                 + D + v+ + ++n 
  EFC39825.1 132 RDDDDDVITCTEKNE 146
                 789999999998885 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.64
     DUF4116  15 alkylseeL.knDke 28 
                 +++++se + k +++
  EFC39825.1 473 CYEFASEIIvKENRN 487
                 889999876566666 PP

  == domain 3  score: 25.6 bits;  conditional E-value: 2.4e-09
     DUF4116   2 rEivlea.vkkn.gsalkylseeLknDkeivlkAvkqngt.....a 40 
                 ++++l+a +k++ +++++ ++++Lk+Dkeiv+ A+k  g+     +
  EFC39825.1 534 KQFILNAlCKIHeWEIITLIDDSLKSDKEIVMTAIKERGSsavqdV 579
                 689999955555567*********************9997555552 PP

>> RIO1  RIO1 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.6   0.4   1.5e-06    0.0045      59     157 ..     291     400 ..     264     406 .. 0.68
   2 ?   -1.3   0.2      0.47   1.4e+03      26      58 ..     464     496 ..     449     573 .. 0.63

  Alignments for each domain:
  == domain 1  score: 16.6 bits;  conditional E-value: 1.5e-06
                 HHHHHHHHHTT--S--EEEEETTEEE.......EE--EETTEEGG....BHHHCG.-HHHHHHHHHHHHHHHHHHHHTSTEEESS-STTSEEEETT.EE CS
        RIO1  59 frnLkrleeagvpvPkpielkrhvlv.......mefigedgvaap....klkdve.eeeeaeelyeevleemrklykeaglvHaDLSeyNvlvded.kv 144
                 +   ++++ a +  P+++++++ +l+       me+i+  g  a     + k+ + +++  ++++ ++le +  l+k++++vH D+   N++v e  ++
  EFC39825.1 291 MGVSEAVKGARLTHPNVVKVHHAMLIryiccieMEYIEG-GSLANyikfNCKKFTiHKDTVKNMLFQCLE-VLLLMKQHEIVHSDIKPDNIMVRESfDI 387
                 555556666666666666666665555555555999992.222220111334444338888888888888.899999*******************9** PP

                 EE--GTTEEETTS CS
        RIO1 145 viIDvsQaveldh 157
                  i D++ +++ + 
  EFC39825.1 388 AIGDFGVSLQNQT 400
                 *999998877655 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.47
                 -HHHHCTTTSTTSTCG--GS-HHHHHHHHHHHH CS
        RIO1  26 kkrkkyvsgekrfkdrksktnprklvklwaekE 58 
                 k+ +++++  ++f ++   +++r+  ++w + E
  EFC39825.1 464 KDSSQRIKACYEFASEIIVKENRNFNNIWFNEE 496
                 555555555555555555555555555554443 PP

>> Telomere_reg-2  Telomere length regulation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.3   0.1      0.15   4.6e+02      13      49 ..      57      93 ..      34     113 .. 0.66
   2 ?   11.6   0.2   9.3e-05      0.28       5      62 ..     455     521 ..     454     541 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.3 bits;  conditional E-value: 0.15
  Telomere_reg-2 13 dkddyekieaaLksaeeLirrkadeveenaveLataL 49
                    +++d++   ++  +ae+L+++ +d+++e  + + ++L
      EFC39825.1 57 ESEDNDDNSLTVAAAEQLLNKMEDDINEGIETINQSL 93
                    4555566677777777777777777766666666655 PP

  == domain 2  score: 11.6 bits;  conditional E-value: 9.3e-05
  Telomere_reg-2   5 kdllelLrdkddyekieaaLksaeeLirrkad..........eveenaveLataLltledkfdienfe 62 
                      +++++L++kd+ ++i+a+ + a+e+i ++++          e++ +  eL ++L+ le+ ++ ++f+
      EFC39825.1 455 HECIQGLKSKDSSQRIKACYEFASEIIVKENRnfnniwfneeEMKPHLRELRKQLI-LEEMTSYKDFK 521
                     79*************************96666588777777777777777777776.34444666665 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   2.5e-05     0.076     142     197 ..     347     401 ..     301     447 .. 0.70

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 2.5e-05
  Kinase-like 142 etiarlllTlqlirlaanLqakglvhgkftvdnllldekgglmlggftaLvragtk 197
                  ++  + +l  q + +   ++++ +vh ++++dn++  e + + +g+f+   +  t 
   EFC39825.1 347 KDTVKNML-FQCLEVLLLMKQHEIVHSDIKPDNIMVRESFDIAIGDFGVSLQNQTM 401
                  45556666.788899999999**************************865555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (640 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1295  (0.0722293); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.71u 0.34s 00:00:01.05 Elapsed: 00:00:00.50
# Mc/sec: 3873.98
//
Query:       EFC39826.1  [L=460]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (460 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1263  (0.0704445); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.32s 00:00:00.98 Elapsed: 00:00:00.53
# Mc/sec: 2588.60
//
Query:       EFC39827.1  [L=329]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    5.7e-12   45.4  29.6    7.1e-12   45.0  29.6    1.0  1  Mg_trans_NIPA  Magnesium transporter NIPA
  ------ inclusion threshold ------
       0.41   10.9   3.9        0.7   10.1   3.9    1.3  1  CAF1A          Chromatin assembly factor 1 subunit A


Domain annotation for each model (and alignments):
>> Mg_trans_NIPA  Magnesium transporter NIPA
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   45.0  29.6   7.9e-16   7.1e-12      51     290 ..      13     255 ..       3     260 .. 0.89

  Alignments for each domain:
  == domain 1  score: 45.0 bits;  conditional E-value: 7.9e-16
  Mg_trans_NIPA  51 lWwaGlltmavGeaanfaayafaPatLvtPLGalsvivsavlasllLkekLkllgllGcllailGstvlvihaPkeeei...eslkevadllvdpa 143
                     ++ G+l   v  +  ++++af   tLv  + ++ v v    + ++  ek+ + + +G++++++G  + vi++ k+ +    ++++ ++ ++ d +
     EFC39827.1  13 RFYVGFLFSLV-WICEMVSFAFVELTLVVSVLSFGVFVGVFYTAWYNAEKITMRDYIGVFITVIGILISVIFSDKIYQPlhpITISFISGQILDFN 107
                    55566554443.46788999*******************************************************987522278899999999988 PP

  Mg_trans_NIPA 144 f.lvyvilvvvvvlvlilyveprkGktnilvyitlcsllgsltvisvkalgiaikltl.aGkaqlkyalawilllvlvicvvlqinyLnkaldifn 237
                      +++vil+v++ ++li+    r   +n+     + + +++   i  k     +k ++ +  +q+k++ ++++l++ v+  +l  ++    l  ++
     EFC39827.1 108 IpILFVILIVILPFILIVLGIFR-VFKNVFFNSSISATFAASNFIIFKLFIELVKTSVeTDDNQFKHWATYLILILSVVYTILHTHFTQVTLVQYE 202
                    65889999998888877665555.5799*********************9999****967789********************************* PP

  Mg_trans_NIPA 238 tsivtPvyyvlfttlvivasailfkefleasvddvlgelsGfllvllgvfllh 290
                     +i   +yy ++  +++  + ++f+e++++++ +++   +G ++ ++g++ll 
     EFC39827.1 203 FTISNVLYYTIMSFITVCGGELIFREWSDTEIFQLVLLFIGWFIQFIGILLLL 255
                    **************************************************985 PP

>> CAF1A  Chromatin assembly factor 1 subunit A
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   3.9   7.8e-05       0.7      34      72 ..     283     320 ..     260     324 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 7.8e-05
       CAF1A  34 ekeldYdyDSdaEWeeeeeeegedleseedeeeeeeddd 72 
                 + +ld+d DSd+E ++ e+ +   l ++e++e   e+ +
  EFC39827.1 283 NVDLDFDSDSDNENSKSEK-QQSALLQDEEDETMLEETE 320
                 5678999999999877655.4444444444444333332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (329 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1762  (0.0982765); expected 358.6 (0.02)
Passed bias filter:                      511  (0.0285013); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.52
# Mc/sec: 1890.46
//
Query:       EFC39828.1  [L=517]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.7e-08   32.3  44.2    0.00039   20.6   5.6    3.2  3  EamA             EamA-like transporter family
    2.1e-07   30.5   6.9    2.1e-07   30.5   6.9    2.3  2  PUNUT            Purine nucleobase transmembrane transport
    0.00092   18.6  20.0     0.0019   17.6   4.4    3.3  3  Sugar_transport  Sugar transport protein
  ------ inclusion threshold ------
      0.059   13.7   1.6       0.26   11.6   0.3    2.7  2  Orf78            Orf78 (ac78)
       0.33   10.7   0.0       0.33   10.7   0.0    2.3  2  Neurensin        Neurensin


Domain annotation for each model (and alignments):
>> EamA  EamA-like transporter family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.8   3.5   5.7e-05      0.21       2      67 ..     110     178 ..     109     185 .. 0.88
   2 !   20.6   5.6   1.1e-07   0.00039      62     136 ..     228     303 ..     217     304 .. 0.91
   3 !   12.2  19.3   4.4e-05      0.16       2     136 ..     320     460 ..     319     461 .. 0.83

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 5.7e-05
        EamA   2 lgillallaalfwaiyfvlskillrkv...spltltfvrfliagillliiallkegklaklslkdwlll 67 
                 lg+l +l+++++w +++ +++ +++++    p+ +t +++ + +i ll ++++  ++++ l+  +wl+ 
  EFC39828.1 110 LGLLCILVVVILWTLGGEAIQLIYSDMdyeKPFLVTYISTSLFSIYLLGFIFVGTWRRPLLKSVSWLIR 178
                 6999*******************9998777999********************9999977777777765 PP

  == domain 2  score: 20.6 bits;  conditional E-value: 1.1e-07
        EamA  62 kdwllllllgllgtvlafllffyalkktsasnaslitslePvftlilsvlll.gekltlkqllgivlillGvllil 136
                    + l+++ ++  ++ + +++yal +ts++  ++i++++ +ft + + l+    +++++ +++i++ l Gv+l++
  EFC39828.1 228 GKTFRLAVIVTFFWFFSNTAYNYALLYTSVASDTIISNTSCLFTFLVGLLIGvETHFSVLRFIAILVTLSGVALVT 303
                 5567789999999**************************************87889******************97 PP

  == domain 3  score: 12.2 bits;  conditional E-value: 4.4e-05
        EamA   2 lgillallaalfwaiyfvlskillrkvspltltfvrfliagillliiallkegkl....aklslkdwllllllgllgtvlafllffyalkktsasnasl 96 
                 lg +l llaa+ ++iy  + k+  ++vs  +++++  ++  ++  +i+++ +g +    + +s+k +++ ++ +l++ vl  ll+  a+  ts+ +a++
  EFC39828.1 320 LGNMLSLLAAMGYGIYSSILKKYEENVSMAMMFGFVGILNLFFNWPILFILWGLDvetfELPSWKIFFATVVNSLISAVLSDLLWALAVVLTSPVIATV 418
                 588999********************9999888877777777777777777777774455555555666666677************************ PP

        EamA  97 itslePvftlilsvlll..gekltlkqllgivlillGvllil 136
                  ++l+  f++++ +l+      ++++  +g++++l+G + ++
  EFC39828.1 419 GLTLTIPFAIVCDMLIRsdFSAFNVMYAFGTLFVLFGFIAVN 460
                 ****************75556778888889999999988776 PP

>> PUNUT  Purine nucleobase transmembrane transport
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.5   6.9     6e-11   2.1e-07      60     195 ..     216     351 ..     208     367 .. 0.83
   2 ?    0.5   1.4     0.076   2.7e+02     166     213 ..     394     443 ..     375     485 .. 0.65

  Alignments for each domain:
  == domain 1  score: 30.5 bits;  conditional E-value: 6e-11
       PUNUT  60 kqkettssslslkklvllyivlGllvavdnllyslgllylpvstfslilatqLaFtaifsali.nkqkftrfiinsvvlltisaallalssssdkpaee 157
                 +q e++s+ +   k + l++++ +  +++n+ y ++lly +v   ++i+ t+ +Ft ++  li ++  f ++ ++++++   + al+ ls+s  + ++ 
  EFC39828.1 216 TQVENQSNDVDVGKTFRLAVIVTFFWFFSNTAYNYALLYTSVASDTIISNTSCLFTFLVGLLIgVETHFSVLRFIAILVTLSGVALVTLSDSHHNGTG- 313
                 44566777888899999*******************************************9997899*********9966666666666665555555. PP

       PUNUT 158 skkkyvigfiltlaasllfaLlLslvellfekvlkket 195
                  k+  v g +l+l a++ ++++ s++++  e+v   + 
  EFC39828.1 314 MKTDTVLGNMLSLLAAMGYGIYSSILKKYEENVSMAMM 351
                 55999*****************9999887777765555 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.076
       PUNUT 166 filtlaasllfaLlLslvellfekvlkket..fslvlemqivlslvatvv 213
                 +i ++ + ll+aL + l+  + ++v  + t  f++v +m i   + a+ v
  EFC39828.1 394 LISAVLSDLLWALAVVLTSPVIATVGLTLTipFAIVCDMLIRSDFSAFNV 443
                 34444455555555555555555555555566777777776666655443 PP

>> Sugar_transport  Sugar transport protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.5   0.3     0.005        18     249     277 ..      93     121 ..      89     124 .. 0.89
   2 !   17.6   4.4   5.2e-07    0.0019      52     185 ..     228     358 ..     216     365 .. 0.87
   3 !    5.3   2.3    0.0029        10      52     120 ..     391     459 ..     375     462 .. 0.87

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.005
  Sugar_transport 249 illLkekktkkelvlviiGivlilvgavl 277
                      +llLk+ kt ++l+  + G+++ilv ++l
       EFC39828.1  93 LLLLKQSKTYRNLFKKFLGLLCILVVVIL 121
                      689*********************99887 PP

  == domain 2  score: 17.6 bits;  conditional E-value: 5.2e-07
  Sugar_transport  52 lkillvslisGllWaigqllqfkalklvgvskamPistglqLvgasLigvlvlgeWstsiqvilGllaliliviGivltslkekkekksee.en 144
                       k++ +++i  ++W ++ +    al + +v+  + is+++ L  + L+g l+  e   +   +l ++a+++ + G++l +l++++++ +   ++
       EFC39828.1 228 GKTFRLAVIVTFFWFFSNTAYNYALLYTSVASDTIISNTSCL-FTFLVGLLIGVE---THFSVLRFIAILVTLSGVALVTLSDSHHNGTGMkTD 317
                      5789999************999999*****999999998877.578999998766...4456899*************9999988888777578 PP

  Sugar_transport 145 lkkgllllllstigyviyvvlaqlvkvdgleailpqaiGmv 185
                      +  g +l ll+++gy iy+ + +  + +   a+++  +G++
       EFC39828.1 318 TVLGNMLSLLAAMGYGIYSSILKKYEENVSMAMMFGFVGIL 358
                      8888888899***************9999999999999986 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.0029
  Sugar_transport  52 lkillvslisGllWaigqllqfkalklvgvskamPistglqLvgasLigvlvlgeWstsiqvilGllal 120
                      +++l+ +++s llWa++ +l+  ++++vg + + P +  + +++ s ++++ +    ++  v++G++a+
       EFC39828.1 391 VNSLISAVLSDLLWALAVVLTSPVIATVGLTLTIPFAIVCDMLIRSDFSAFNVMYAFGTLFVLFGFIAV 459
                      45788899*********************************9999999999887777777778888876 PP

>> Orf78  Orf78 (ac78)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.3   7.3e-05      0.26      30      81 ..      52     120 ..      34     123 .. 0.61
   2 ?   -1.5   0.0       0.9   3.2e+03      44      85 ..     213     254 ..     196     264 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 7.3e-05
       Orf78  30 dndkaenkkekksaaeknditekesn.....................aaekaqalnillisllavvcvlvlly 81 
                 +n+++++++++++++ +  ++    +                       ++ +++ +l+ ++l ++c+lv+++
  EFC39828.1  52 NNTSSDDNNKNNNITIDDPME----EkdeeeeeehferpknlssfllLLKQSKTYRNLFKKFLGLLCILVVVI 120
                 111111111111122222222....1233466678899999**99998899999**************99986 PP

  == domain 2  score: -1.5 bits;  conditional E-value: 0.9
       Orf78  44 aeknditekesnaaekaqalnillisllavvcvlvllyviyY 85 
                  +++++++++++    +++  ++++++  +++     y+++Y
  EFC39828.1 213 LSQTQVENQSNDVDVGKTFRLAVIVTFFWFFSNTAYNYALLY 254
                 333334444444445556666666666666666666666666 PP

>> Neurensin  Neurensin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.2      0.96   3.4e+03      47      58 ..     290     301 ..     247     330 .. 0.66
   2 ?   10.7   0.0   9.1e-05      0.33      40      72 ..     440     472 ..     429     482 .. 0.87

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.96
   Neurensin  47 vgtlvlllGvta 58 
                 +++lv l Gv+ 
  EFC39828.1 290 IAILVTLSGVAL 301
                 344444444443 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 9.1e-05
   Neurensin  40 lwkvslvvgtlvlllGvtallvGylvprrlelv 72 
                   +v+ ++gtl++l+G +a+ ++y +p++   +
  EFC39828.1 440 AFNVMYAFGTLFVLFGFIAVNTSYYLPKKARKY 472
                 5689999*********************98766 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (517 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1739  (0.0969937); expected 358.6 (0.02)
Passed bias filter:                      687  (0.0383178); expected 358.6 (0.02)
Passed Vit filter:                        89  (0.00496402); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.74u 0.36s 00:00:01.10 Elapsed: 00:00:00.53
# Mc/sec: 2952.61
//
Query:       EFC39829.1  [L=1419]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.7e-16   57.9   2.9    5.6e-15   55.2   2.9    1.9  1  PhoD            PhoD-like phosphatase
    6.3e-15   55.3   0.2      2e-12   47.3   0.2    2.7  1  C2              C2 domain
    8.2e-07   29.8   0.0    2.4e-06   28.3   0.0    1.8  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
     0.0021   17.9   0.1     0.0062   16.4   0.1    1.8  1  F-box-like      F-box-like
  ------ inclusion threshold ------
      0.025   13.2   0.0        2.2    6.8   0.0    2.2  2  Actin           Actin
      0.086   12.8   0.1       0.31   11.0   0.1    2.1  1  F-box           F-box domain


Domain annotation for each model (and alignments):
>> PhoD  PhoD-like phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   55.2   2.9   1.9e-18   5.6e-15       3     346 ..     351     708 ..     349     710 .. 0.66

  Alignments for each domain:
  == domain 1  score: 55.2 bits;  conditional E-value: 1.9e-18
        PhoD   3 vvSCqnyea..gyfnayrelaee.edlDlvlhlGDyiYeyg.pgeyase....aaelgreveppkeivtladYReryaqyktdadlqaahaaapfivvw 93 
                 +vSC+  e       +++++ e+ ++lD+++h+GD iY +  ++ ++ +    ++++  e+   +e +  + +R+ y+++   +  +++ ++++ ++++
  EFC39829.1 351 AVSCNLIERriPDKDVWERMLEKvDELDILMHCGDQIYSDCgHNAFDEAkricDGRIKLEKD--EENEIKELFRKYYRLNWNHPPTRRIMSQVSNLMIL 447
                 6777777641244689999999856***************5333333322123444444444..44555566*************************** PP

        PhoD  94 DDHEvaNnswsggaenhqeetegdfek.rkaaAlqAyfEwmP.irea.k......pgeeeriyrsfeyGdladlflLDtRqyrrdqavsyegdeleaae 183
                 DDHE++++ w +++  ++   +g++e      A+  y E++  +re         + ++++ y    +Gd  ++++LD+R  r+ ++            
  EFC39829.1 448 DDHEIRDD-WGSDECDKD---KGSVEYyIGRLAREVYWEYQRsLREDvLsmnyeeTFKKHEGYY-HVFGD-YAILFLDLRAARSFNSE----------- 529
                 ********.*99777776...666654156789*******641455544222211222233333.34899.567779******99984........... PP

        PhoD 184 aevkdpartlLGeeQeqwLkaeLkasrar.......Wkvlaqqvlmskvd..ld..aelaega....lpvnlDawd.GypaeRe.rlleti....keak 261
                     + ++ +L ++Q ++L+++L + +++         +   +v++  ++  ++        +    l+   D w+ G + + +  +l+ i    ke+ 
  EFC39829.1 530 ---LSGDKPFLTQPQWDDLNNWLFKDNNAlasenikALICVCSVPLVFLNkkMTdsLP----KitskLSDMRDHWNyGHQFNEQiGILNSInrwkKEQP 621
                 ...2345678888888888888776666555555553333444444433311222333....1444478888999536666555755555544447788 PP

        PhoD 262 irnvVvLtGDvHaawandldykdpdgeavgvEfvtgsvssgglgeyla.......eaadateeallaanpelkytelderGyveldlteeav 346
                  r+ V+++GDvH   ++++ +   ++e v   + t+svs ++++  l        +++++ +e+   + ++ k+t+ ++ G++++ ++ e+v
  EFC39829.1 622 NREAVFVAGDVHIGGVTEI-M--YNNEMVLKQLTTSSVSNNEFSWCLGlsmrfmlTKSSELKEGW--TFKHQKWTRKRNYGILNIATDGEKV 708
                 89*****************.3..33335899**********999988888866443333333333..6678888888888888887776665 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   47.3   0.2   6.7e-16     2e-12       3     101 ..       3     143 ..       1     145 [. 0.90

  Alignments for each domain:
  == domain 1  score: 47.3 bits;  conditional E-value: 6.7e-16
                 EEEEEEEEESSSSSSTTSSCEEEEEEEE.............ECEEEEEE-SCSSSSSSEEEEEEEEEESC...........................HT CS
          C2   3 levtvieAknLpnkdkkgssdpyvkvsl.............dgkqkakTrviknslnPvWnekftfevae...........................le 61 
                 +++tv+++++Lp++d++g sd ++++++             +++++++T+++ ++lnPv+ne+f+f+ +e                           + 
  EFC39829.1   3 FRITVVKCTDLPPMDANGLSDGFCELWVvnsktnkyleppkNQNEIKRTQIVMKNLNPVFNETFEFDFSEklkrreidfatrvseeddidddyilddPM 101
                 79************************************************99*******************9999999999999999999999999999 PP

                 TSEEEEEEEEECSSSTEEEEEEEEEEGHH..HHTTHHHHEEE CS
          C2  62 eakLeveVfdndrlskddfiGkveiplst..llsgeeaegwy 101
                 +  L +++ d+d+++k+d+iG v +++    l+ +e++++++
  EFC39829.1 102 DNLLMIRIVDYDKFTKNDVIGFVLLQVFGlnLKPNEKQRRTF 143
                 999999999999999999999999998775555555555555 PP

>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.3   0.0   8.1e-10   2.4e-06       2      91 ..     831     923 ..     830     927 .. 0.74

  Alignments for each domain:
  == domain 1  score: 28.3 bits;  conditional E-value: 8.1e-10
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--........EEE................---TT-EEEEE-..B-TEEE--B CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekeseeGGe........lelyekdk......eavkikpkkgrlvlFesdellpHevlpv 82 
                      +++y+eg+++kpH+D     +++++ +ltvl+yL+  +s++ G                +      +  +   + g+++lF+ +++  H+++pv
      EFC39829.1 831 RISKYEEGGYFKPHMDGQFVIDDNRKSILTVLIYLS--QSFSAGTnyyhciekK------DnslllqHVLSTNCNIGDCILFNHEIF--HSGEPV 915
                     5789************8774444468*********6..6777776465443330......2466655555556799********999..****** PP

                     .-SS-EEEE CS
  2OG-FeII_Oxy_3  83 tkggeRlsl 91 
                        g++++l
      EFC39829.1 916 DY-GTKYVL 923
                     55.599987 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.4   0.1   2.1e-06    0.0062       3      44 ..     999    1040 ..     998    1044 .. 0.75

  Alignments for each domain:
  == domain 1  score: 16.4 bits;  conditional E-value: 2.1e-06
  F-box-like    3 rLPdEiLlqIFsyLppsdLlr.lalVCrrWrrvaldtplLWrr 44  
                   LP E+L+ IFsyL p++ +  +    r  +  a+d  + W++
  EFC39829.1  999 TLPSEVLSLIFSYLTPTEVCTsIVYLNRNLNASARDQ-YTWKQ 1040
                  7*************88877664677777777777666.77765 PP

>> Actin  Actin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.0   0.00074       2.2      80     171 ..    1169    1259 ..    1160    1317 .. 0.92
   2 ?    4.1   0.0    0.0048        14     328     395 ..    1329    1395 ..    1278    1399 .. 0.74

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.00074
       Actin   80 wehvlkeelkvdpeehpllltepplnppkqrekalEivfEkfkvpalylaksavlsafasgkstglvvDsGasvtsvvpVldGyvLkkairr 171 
                  +e++l++ l    +++p+ll++p + ++++ e + +i+f   ++pal +  s +l + ++g  +  ++D+  +   v+ V +G +L  +++ 
  EFC39829.1 1169 IEYILRDSLDLSLKQYPVLLAKPFMFSSEDEEILKDILFG-AGIPALHIEHSYTLISLYYGMPNCTIIDIRPDYVGVAVVENGKPLPTSTFF 1259
                  789999*********************************6.69******************************************9988765 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.0048
       Actin  328 ivvtGGnsllpglteRlekelaqlaskgvkvkiiapeeerkysaW...iGGSiLAslgtfqqlwvskqEYe 395 
                   ++ G  sl+pgl  Rl k+l+ ++ ++     + p     + +W    GG i+++l++f++ +    +Ye
  EFC39829.1 1329 TIIRGELSLVPGLVTRLIKDLSGKFVEKNFTFTHDP----ENCVWdilKGGKIMSNLSDFKEKCQKSGNYE 1395
                  689999*****************6655444444444....455553337**********999887777777 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1    0.0001      0.31       4      24 ..     998    1018 ..     995    1020 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.0001
                  HHS-HHHHHHHHHTS-HHHHH CS
       F-box    4 srLPsevlrhILerLplsdll 24  
                  s LPsevl  I+++L +++++
  EFC39829.1  998 STLPSEVLSLIFSYLTPTEVC 1018
                  67*****************99 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      379  (0.0211389); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.86u 0.33s 00:00:01.19 Elapsed: 00:00:00.52
# Mc/sec: 8221.76
//
Query:       EFC39830.1  [L=497]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
      0.031   14.8   1.9        8.1    7.1   0.0    3.6  3  PepSY_like  Putative beta-lactamase-inhibitor-like, PepSY-lik


Domain annotation for each model (and alignments):
>> PepSY_like  Putative beta-lactamase-inhibitor-like, PepSY-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0      0.01   1.8e+02      34      65 ..      24      59 ..      13      63 .. 0.61
   2 ?    7.1   0.0   0.00045       8.1      33      68 ..      70     105 ..      65     114 .. 0.79
   3 ?    1.9   0.6     0.018   3.2e+02      36      70 ..     113     149 ..      99     159 .. 0.72

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.01
                GGS-HHHHHHHHHHTTT....EEEEEEEECSSEEEE CS
  PepSY_like 34 silpkavlkaiknsypd....ekvtkierkkkeyei 65
                + l++++ k+ik+  ++    e v+k+  ++  y i
  EFC39830.1 24 ASLHQSISKTIKEVLKNdnfrERVEKVYLPRLYYQI 59
                345555555555553332444899998888877776 PP

  == domain 2  score: 7.1 bits;  conditional E-value: 0.00045
                 GGGS-HHHHHHHHHHTTTEEEEEEEECSSEEEEEET CS
  PepSY_like  33 lsilpkavlkaiknsypdekvtkierkkkeyeiele 68 
                 l+ l  ++++a+kn++ de v++i r + e+ +  e
  EFC39830.1  70 LDSLMIPIMNAFKNKFGDEAVRRISRVEFEVDFMME 105
                 5667779*****************997755555555 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.018
                 S-HHHHHHHHHH..TTTEEEEEEEECSSEEEEEETTS CS
  PepSY_like  36 lpkavlkaikns..ypdekvtkierkkkeyeielene 70 
                 ++ +v k+i  s   +de+++ ie+++k + +++e++
  EFC39830.1 113 VEHTVDKTIILSneRSDEEFKSIENPNKLFHVDFEKK 149
                 55555554433213667**************999984 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (497 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       950  (0.0529868); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        48  (0.00267723); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.28s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 3164.55
//
Query:       EFC39831.1  [L=1412]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.6e-51  173.4  40.8    2.7e-31  109.2  19.9    2.2  2  ABC_membrane     ABC transporter transmembrane region
    9.8e-48  162.2   0.7    3.9e-27   95.4   0.1    2.8  2  ABC_tran         ABC transporter
    2.6e-06   27.4   0.3     0.0012   18.8   0.0    2.6  2  RsgA_GTPase      RsgA GTPase
    3.5e-06   27.3   0.6       0.11   12.5   0.0    2.8  2  DUF87            Helicase HerA, central domain
    1.4e-05   24.7   5.2      0.023   14.4   0.8    2.6  2  AAA_29           P-loop containing region of AAA domain
    3.4e-05   23.9   3.0       0.14   12.2   0.1    2.9  2  MMR_HSR1         50S ribosome-binding GTPase
    9.4e-05   21.6   0.1      0.025   13.6   0.0    2.4  2  T2SSE            Type II/IV secretion system protein
    0.00022   21.3   1.4       0.13   12.4   0.0    3.1  2  Dynamin_N        Dynamin family
    0.00024   20.6  13.2     0.0038   16.7   0.1    3.7  4  SMC_N            RecF/RecN/SMC N terminal domain
     0.0015   18.8   0.3        2.9    8.1   0.2    2.8  2  AAA_22           AAA domain
     0.0016   17.7   0.5        1.6    7.8   0.0    2.7  3  NB-ARC           NB-ARC domain
     0.0023   18.3   0.1        2.3    8.6   0.0    2.5  2  AAA_16           AAA ATPase domain
     0.0036   16.9   0.1       0.54    9.8   0.0    2.4  2  AAA_7            P-loop containing dynein motor region
     0.0062   16.5   0.0        2.9    7.8   0.0    2.6  2  NACHT            NACHT domain
     0.0081   15.5   0.7        1.6    8.0   0.0    2.3  2  FtsK_SpoIIIE     FtsK/SpoIIIE family
  ------ inclusion threshold ------
      0.012   15.9   0.7        6.2    7.1   0.0    3.3  3  Roc              Ras of Complex, Roc, domain of DAPkinase
      0.012   15.2   0.0        5.6    6.5   0.0    2.3  2  AAA_25           AAA domain
      0.022   14.5   0.9        1.7    8.4   0.0    2.7  2  AAA_24           AAA domain
      0.022   15.1   0.2        4.1    7.8   0.0    3.1  2  RNA_helicase     RNA helicase
      0.042   13.1   1.3        9.1    5.5   0.0    3.0  3  Septin           Septin
      0.047   13.4   0.1        7.3    6.3   0.0    2.4  2  AAA_30           AAA domain
      0.055   14.0  12.0      0.084   13.4   0.6    3.8  3  AAA_23           AAA domain
        0.1   12.4   4.8        4.5    7.0   0.1    3.3  3  AAA_21           AAA domain, putative AbiEii toxin, Type IV T
       0.11   12.2   0.1         20    4.9   0.0    2.6  2  Viral_helicase1  Viral (Superfamily 1) RNA helicase
       0.12   11.4   0.2        4.2    6.3   0.0    2.2  2  MeaB             Methylmalonyl Co-A mutase-associated GTPase 
       0.17   11.1   1.1        5.6    6.2   0.0    2.7  2  Zeta_toxin       Zeta toxin
       0.29   10.7   2.4         13    5.3   0.2    2.6  2  cobW             CobW/HypB/UreG, nucleotide-binding domain
       0.56    9.9   6.2        5.6    6.7   0.0    3.3  3  ATP_bind_1       Conserved hypothetical ATP binding protein
        6.7    6.6   6.6         14    5.6   0.2    3.1  2  NTPase_1         NTPase


Domain annotation for each model (and alignments):
>> ABC_membrane  ABC transporter transmembrane region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   69.9  12.9   4.3e-22   2.6e-19      42     273 ..     267     495 ..     236     496 .. 0.87
   2 !  109.2  19.9   4.4e-34   2.7e-31       2     271 ..     843    1110 ..     843    1113 .. 0.92

  Alignments for each domain:
  == domain 1  score: 69.9 bits;  conditional E-value: 4.3e-22
                   HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHSCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane  42 vysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtnsvGellsrltndvsklrdglgeklglffqslltfvgglivmfy 138
                    + +ll+l+ ++ +i+   ++y   ++   ++ ++++ +f+ki r   s  ++ ++Ge+++++t+d  ++ +++ +++ +++ +++++vg+  ++++
    EFC39831.1 267 GIVILLFLCNILPTIFINQYTYGVGNLWFAWRGCIQAAVFQKINRITSSERSKFKSGEITNLFTTDPTRIATLILYFHECWVVPVSLLVGLSMICIF 363
                   4556667777777777777777779999*************************************************************98888888 PP

                   HSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHHHHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
  ABC_membrane 139 lgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgirtVkafgreeyflekfekaleeakkagikkaianglligitqllg 235
                   +g + ++++++ ++l+ +++ v+akil+k++   +k ++++ + ++E l+gir +k f  ee++ ek  ++++++ k  + + ++++ ++ ++ +l+
    EFC39831.1 364 FGYS-AFIGVGAMLLVSPLIPVLAKILTKVEGWLSKFRDERVKNLNELLNGIRIIKFFVFEEKMKEKVMESRKKESKGLF-ASVLTMSSQRFAAVLM 458
                   8887.9*****************************************************************999988755.5556666899999999 PP

                   HHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHHHH CS
  ABC_membrane 236 llsyalalwfGttlvisgelsvgdlvvflslfailfga 273
                   +++   ++++++++   g+l+++++++ l lf ++  +
    EFC39831.1 459 SIVGGSVTFISYAYF-GGQLTISNMFTGLILFDTFRVP 495
                   999999999999999.88*********99999998876 PP

  == domain 2  score: 109.2 bits;  conditional E-value: 4.4e-34
                    HHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSTCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSTHHHHHHSC CS
  ABC_membrane    2 iliillailagvlsplfplvlgrildtlldkgdpetealnvysllllllglaqfilallqsyllnvtgerlskrlrrklfkkilrqpmsffdtns 96  
                    i+++l++i++++ s+      + ++++++ +    +  +  y ++++++gl ++++a l++  +  ++ ++s+  ++k++++il++p++ffd+n+
    EFC39831.1  843 IILVLFSIISCLFSVSSKAGGQIWISVMNNDYLGLD--IFTYVWIFFGIGLTDAFFASLKELAFGLASLKASNSFHKKMLNNILHAPTRFFDQNP 935 
                    577889999999999888888899999988655555..889****************************************************** PP

                    HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTHH CS
  ABC_membrane   97 vGellsrltndvsklrdglgeklglffqslltfvgglivmfylgwkltlvllailpliilvsaviakilkklkkkeqkavakassvaeEslsgir 191 
                    +G++l+r+t dv  l++ + + l +f++ +++++ +l+++ ++ + + +v+++i++++++v+ ++  +++++++ e+ ++++a s+++  l+g++
    EFC39831.1  936 TGRILNRFTQDVVVLDTQMIFALPQFITTIISVCFTLVMISIVTPLFLIVVIPIALVFFVVQEYYRATSREIRRLESISRSPAMSHFNSCLEGVK 1030
                    *********************************************************************************************** PP

                    HHHHTTTHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTSSTHHHHHHHHHHHHHHH CS
  ABC_membrane  192 tVkafgreeyflekfekaleeakkagikkaianglligitqllgllsyalalwfGttlvisgelsvgdlvvflslfailf 271 
                    t+ka   +e  ++    +++  +k ++ + ++n++l++++ql++ l+++++++f++ + + +  +   l  +++++ +l+
    EFC39831.1 1031 TIKAALIHESIYKDNFMKIDFTNKHSYGRFLINRWLGVRIQLVAQLVIFFTALFAIITKHFQHNNEALLALVITYSLQLS 1110
                    ***988888888888899************************************99988877666666666677776665 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   64.5   0.1   2.3e-20   1.4e-17       2     135 ..     578     714 ..     577     716 .. 0.74
   2 !   95.4   0.1   6.3e-30   3.9e-27       1     137 []    1180    1326 ..    1180    1326 .. 0.92

  Alignments for each domain:
  == domain 1  score: 64.5 bits;  conditional E-value: 2.3e-20
                 EEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH.................HHHT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.................xxxx RF
    ABC_tran   2 knvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren.................esde 83 
                 +n++l l++g+++ i+G++G+GKStL++ ++g++   eG+++++            + +++ + ++p + + + vr+n                  +  
  EFC39831.1 578 SNLNLILEKGKLYSIIGDTGSGKSTLISSIIGESIVSEGSLKVN-----------PQLSLSLCDENPWMINSS-VRNNiifdkslefdsekynrvLEVC 664
                 799**************************************777...........444555555555555544.5555555555542221111124444 PP

                 CHHHHHHHSTTGGTTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEEST CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  84 eiekalsklglkelkdtvvksspssLSgGqkqrvalarallkkpkllllDEp 135
                 ++++ l+++++  +++t ++ s+ +LS Gq+ r++lara  ++++++++D  
  EFC39831.1 665 QLKDDLEQFSN--FDETEIGFSGINLSVGQRHRISLARACYSNSDIIIMDST 714
                 46666666665..5599999999***************************76 PP

  == domain 2  score: 95.4 bits;  conditional E-value: 6.3e-30
                  EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--SEEEEEETTCEGGGB-HHHCCHCEEEE-SS--S-TTSBHHHH......HHHTCHHHHHHH CS
                  xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx......xxxxxxxxxxxx RF
    ABC_tran    1 lknvslklkegekvaivGenGaGKStLlkllagllkpteGeilldgkdlkeqeleslrkeigvlpqepqlfpeltvren......esdeeiekalsk 91  
                  l+ ++l++k+g+k+++vG++G+GKStLl  l +  +  eG+i++dg d++++ l+ lrk++ ++pq p lf+++ +r n       +d ei kal++
  EFC39831.1 1180 LNSIQLEIKPGTKIGVVGRTGSGKSTLLISLFRFIEASEGNITIDGVDISQIGLKTLRKSLLIIPQIPILFSGT-IRYNldpfneFQDHEIWKALER 1275
                  6899**********************************************************************.99999***98777779999999 PP

                  STTGG......TTCBGESTTSGGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                  xxxxx......xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran   92 lglke......lkdtvvksspssLSgGqkqrvalarallkkpkllllDEpta 137 
                  + +ke      l   +v++++s++S G++q ++l+r++l+++k++++DE ta
  EFC39831.1 1276 VHMKEkiqqigLSG-NVTENGSNFSIGERQLLSLCRCILRRAKIIIFDESTA 1326
                  99999666663444.445888****************************996 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0     2e-06    0.0012      20     124 ..     501     612 ..     497     623 .. 0.70
   2 ?    6.0   0.0     0.016        10      95     121 ..    1185    1212 ..    1162    1240 .. 0.77

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 2e-06
                  EEEEESTTTT--HHHHHHHHHHHHHTT-EEEEEEE-GGG--HHH.....HHHHHHHHHHHTTSEE..EE--TTTHTTHHHHHHHCTT.SEEEEECSTT CS
  RsgA_GTPase  20 livvslkepelslnlldrfLvlaeekgiepvivlnKiDlleeee.....eleelkeelealgyev..llvsaktkegleelkellkd.ktsvlvGqSG 109
                  l++++l++  +s +++ rfL   e+ +++ +   nK+ l +e +     + ++  e+  a+++e   +++ ++ ++ +++l+  l++ k+  ++G +G
   EFC39831.1 501 LVLSGLVSSYVSAKRVGRFLYSDEQVHLP-HDHYNKAHLWNEVSnrsssDHSTNLEDNVAIEFENasIKWTEDGETIVSNLNLILEKgKLYSIIGDTG 597
                  56777888888999999999988888775.5577999999999877655333333333333333300333333345567777788878********** PP

                  SSHHHHHHHHCTT-- CS
  RsgA_GTPase 110 vGKStLinallpele 124
                   GKStLi ++++e  
   EFC39831.1 598 SGKSTLISSIIGESI 612
                  **********99865 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.016
                   HHCTT.SEEEEECSTTSSHHHHHHHHCT CS
  RsgA_GTPase   95 ellkd.ktsvlvGqSGvGKStLinallp 121 
                    ++k    + +vG +G GKStL+ +l  
   EFC39831.1 1185 LEIKPgTKIGVVGRTGSGKSTLLISLFR 1212
                   555552344589**********988865 PP

>> DUF87  Helicase HerA, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.5   0.0   0.00018      0.11      27      48 ..     591     612 ..     585     656 .. 0.90
   2 !   11.9   0.2   0.00029      0.18      25      45 ..    1192    1212 ..    1184    1223 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 0.00018
       DUF87  27 AilgsTGsGKSntvavLleell 48 
                  i+g TGsGKS+++++++ e +
  EFC39831.1 591 SIIGDTGSGKSTLISSIIGESI 612
                 69***************97655 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 0.00029
       DUF87   25 HlAilgsTGsGKSntvavLle 45  
                   ++++g+TGsGKS++  +L++
  EFC39831.1 1192 KIGVVGRTGSGKSTLLISLFR 1212
                  589************999987 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.4   0.8   3.8e-05     0.023      22      41 ..     586     606 ..     578     609 .. 0.82
   2 !   11.4   0.2   0.00032       0.2      17      39 ..    1185    1207 ..    1180    1212 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 3.8e-05
      AAA_29  22 kg.atlltGpsGsGKSTllDA 41 
                 kg  + ++G++GsGKSTl+ +
  EFC39831.1 586 KGkLYSIIGDTGSGKSTLISS 606
                 455788************965 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 0.00032
      AAA_29   17 ieidlkgatlltGpsGsGKSTll 39  
                  +ei++   + ++G++GsGKSTll
  EFC39831.1 1185 LEIKPGTKIGVVGRTGSGKSTLL 1207
                  56666667789***********8 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.8   0.3   0.00064       0.4       3      24 ..     591     611 ..     590     621 .. 0.84
   2 !   12.2   0.1   0.00023      0.14       1      22 [.    1192    1213 ..    1192    1242 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.8 bits;  conditional E-value: 0.00064
                 EEEESTTSSHHHHHHHHHTSTE CS
    MMR_HSR1   3 aivGrpNvGKStLinaltgeka 24 
                  i+G + +GKStLi++++ge +
  EFC39831.1 591 SIIGDTGSGKSTLISSIIGE-S 611
                 59****************97.3 PP

  == domain 2  score: 12.2 bits;  conditional E-value: 0.00023
                  EEEEEESTTSSHHHHHHHHHTS CS
    MMR_HSR1    1 evaivGrpNvGKStLinaltge 22  
                  ++++vGr+ +GKStL+ +l++ 
  EFC39831.1 1192 KIGVVGRTGSGKSTLLISLFRF 1213
                  699*************999874 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.4   0.1     0.013       8.2     122     152 ..     580     610 ..     540     618 .. 0.75
   2 !   13.6   0.0   4.1e-05     0.025     116     161 ..    1177    1222 ..    1157    1232 .. 0.80

  Alignments for each domain:
  == domain 1  score: 5.4 bits;  conditional E-value: 0.013
       T2SSE 122 lrkavrerglilvsGgTgsGKttllyallke 152
                 l+  +++ +l  + G TgsGK+tl+ +++ e
  EFC39831.1 580 LNLILEKGKLYSIIGDTGSGKSTLISSIIGE 610
                 44444455555677**********9998765 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 4.1e-05
       T2SSE  116 ekiaevlrkavrerglilvsGgTgsGKttllyallkeinksderiv 161 
                  + + + ++  ++    i v G TgsGK+tll +l  +i++s+ +i 
  EFC39831.1 1177 DPVLNSIQLEIKPGTKIGVVGRTGSGKSTLLISLFRFIEASEGNIT 1222
                  556677777888888999***********************88885 PP

>> Dynamin_N  Dynamin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0    0.0002      0.13       3      28 ..     592     617 ..     591     680 .. 0.86
   2 ?    6.5   0.3     0.013       8.2       1      19 [.    1193    1211 ..    1193    1234 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.0002
                 EEEBTTTTHHHHHHHHHTS--S---S CS
   Dynamin_N   3 vvGsqSsGKSSvlnaLlgedilprgp 28 
                 ++G++ sGKS+++ +++ge i   g+
  EFC39831.1 592 IIGDTGSGKSTLISSIIGESIVSEGS 617
                 79******************987776 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.013
                  EEEEEBTTTTHHHHHHHHH CS
   Dynamin_N    1 iavvGsqSsGKSSvlnaLl 19  
                  i vvG + sGKS++l +L 
  EFC39831.1 1193 IGVVGRTGSGKSTLLISLF 1211
                  79************97775 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.2       7.2   4.5e+03     189     213 ..     222     246 ..     212     251 .. 0.79
   2 !    6.5   0.5    0.0083       5.1      26      44 ..     589     607 ..     580     621 .. 0.86
   3 ?    4.9   0.1     0.025        15      27      48 ..    1193    1213 ..    1180    1222 .. 0.73
   4 !   16.7   0.1   6.1e-06    0.0038     117     208 ..    1263    1365 ..    1221    1373 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 7.2
                 TSEEEEE-SSHHHCCC-SCEEEEEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 189 naQfivislreemlekadklvgvtk 213
                 n+Q+ v+++++e+l++a  +   t+
  EFC39831.1 222 NVQYSVVAFQNETLQNAALITNSTF 246
                 78999**********9987776666 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0083
                 EEEEEESTTSSHHHHHHHH CS
                 xxxxxxxxxxxxxxxxxxx RF
       SMC_N  26 ftaivGpNGSGKsnlldAi 44 
                 + +i+G  GSGKs l+ +i
  EFC39831.1 589 LYSIIGDTGSGKSTLISSI 607
                 678**************99 PP

  == domain 3  score: 4.9 bits;  conditional E-value: 0.025
                  EEEEESTTSSHHHHHHHHHHHC CS
                  xxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N   27 taivGpNGSGKsnlldAilFvL 48  
                    +vG+ GSGKs ll ++ F +
  EFC39831.1 1193 IGVVGRTGSGKSTLLISL-FRF 1213
                  359***********9888.654 PP

  == domain 4  score: 16.7 bits;  conditional E-value: 6.1e-06
                  EE-HHHHHHHHHCTT-STT...............CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHHHHCTTSEEEEE-SS CS
                  xxxxxxxxxxxxxxxxxxx...............xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N  117 evtkkevsellesagiske...............lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellkeksknaQfivislr 198 
                  e + +e+ + le+++++++               ++S Ge++L++l         ++a + ++De  a  D++  ++v ++++e+ k++ +i +++r
  EFC39831.1 1263 EFQDHEIWKALERVHMKEKiqqiglsgnvtengsNFSIGERQLLSLCRC----ILRRAKIIIFDESTAFVDHNSDEIVQKVIREEFKESTIITVAHR 1355
                  455577777777777777788888888888888899******9887644....468899************************************** PP

                  HHHCCC-SCE CS
                  xxxxxxxxxx RF
       SMC_N  199 eemlekadkl 208 
                   +++ ++d +
  EFC39831.1 1356 LDTIIDSDMV 1365
                  9998887765 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.1   0.2    0.0048       2.9       5      24 ..     587     606 ..     584     613 .. 0.85
   2 !    7.5   0.0    0.0077       4.8      10      30 ..    1195    1215 ..    1188    1339 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.0048
      AAA_22   5 agilvvtGesGtGKTtllrr 24 
                  ++  ++G +G+GK+tl+  
  EFC39831.1 587 GKLYSIIGDTGSGKSTLISS 606
                 67889***********9865 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0077
      AAA_22   10 vtGesGtGKTtllrrlleqld 30  
                  v+G +G+GK+tll  l++  +
  EFC39831.1 1195 VVGRTGSGKSTLLISLFRFIE 1215
                  89**********999988764 PP

>> NB-ARC  NB-ARC domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0     0.004       2.5      22      50 ..     589     617 ..     574     668 .. 0.80
   2 !    7.8   0.0    0.0026       1.6      21      43 ..    1191    1213 ..    1173    1235 .. 0.79
   3 ?   -3.3   0.0       6.7   4.1e+03      83     111 ..    1295    1323 ..    1261    1355 .. 0.63

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.004
                 EEEEEESTTSSHHHHHHHHCCSHCCCCCC CS
      NB-ARC  22 vvalvGmgGvGKttlakqilnksdevegr 50 
                 + ++ G  G+GK+tl+++i+ +s   eg 
  EFC39831.1 589 LYSIIGDTGSGKSTLISSIIGESIVSEGS 617
                 4589***************9986655555 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0026
                  EEEEEEESTTSSHHHHHHHHCCS CS
      NB-ARC   21 lvvalvGmgGvGKttlakqilnk 43  
                    +++vG+ G+GK+tl+ + ++ 
  EFC39831.1 1191 TKIGVVGRTGSGKSTLLISLFRF 1213
                  4599************9888775 PP

  == domain 3  score: -3.3 bits;  conditional E-value: 6.7
                  SSSS-STTSHHHHHHHHCCCTTEEEEEEE CS
      NB-ARC   83 leekeeveslkrklvrlLltkrfllvlDD 111 
                   ++++ +e     l+r +l++  ++++D 
  EFC39831.1 1295 GSNFSIGERQLLSLCRCILRRAKIIIFDE 1323
                  34444444466778888888888888875 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.1     0.012       7.2      25      44 ..     588     607 ..     574     630 .. 0.80
   2 !    8.6   0.0    0.0037       2.3      29      52 ..    1195    1218 ..    1182    1274 .. 0.87

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.012
      AAA_16  25 elvllsGesGvGKsslvrel 44 
                  l  ++G+ G+GKs+l+ ++
  EFC39831.1 588 KLYSIIGDTGSGKSTLISSI 607
                 57789************876 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0037
      AAA_16   29 lsGesGvGKsslvrellralekdg 52  
                  ++G  G+GKs+l+ +l+r +e+++
  EFC39831.1 1195 VVGRTGSGKSTLLISLFRFIEASE 1218
                  89***************9999884 PP

>> AAA_7  P-loop containing dynein motor region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.8   0.0   0.00087      0.54      21      54 ..     575     608 ..     557     627 .. 0.80
   2 ?    4.4   0.0     0.039        24      29      58 ..    1186    1215 ..    1180    1224 .. 0.80

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00087
       AAA_7  21 rysyllelllknkkpvllvGptGtGKtviikdll 54 
                  +   l+l+l+++k   ++G+tG+GK+++i++++
  EFC39831.1 575 TIVSNLNLILEKGKLYSIIGDTGSGKSTLISSII 608
                 555668999*********************9954 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.039
       AAA_7   29 llknkkpvllvGptGtGKtviikdllkkld 58  
                   +k + ++ +vG tG+GK++++ +l++ ++
  EFC39831.1 1186 EIKPGTKIGVVGRTGSGKSTLLISLFRFIE 1215
                  5677788899**********9988777655 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0048       2.9       4      21 ..     591     608 ..     588     648 .. 0.90
   2 ?    5.9   0.0     0.018        11       5      22 ..    1195    1212 ..    1192    1221 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0048
                 EEEC-TTTCHHHHHHHHH CS
       NACHT   4 ilqGeaGsGKTtLlqkla 21 
                  + G+ GsGK+tL+ +++
  EFC39831.1 591 SIIGDTGSGKSTLISSII 608
                 589***********9998 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.018
                  EEC-TTTCHHHHHHHHHH CS
       NACHT    5 lqGeaGsGKTtLlqklal 22  
                  + G+ GsGK+tLl +l +
  EFC39831.1 1195 VVGRTGSGKSTLLISLFR 1212
                  79***********98876 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.3     0.018        11      44      60 ..     592     608 ..     582     615 .. 0.91
   2 !    8.0   0.0    0.0026       1.6      41      59 ..    1192    1210 ..    1174    1213 .. 0.81

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.018
                   EE--TTSSHHHHHHHHH CS
  FtsK_SpoIIIE  44 vaGatgsGKStalntLi 60 
                   ++G tgsGKSt + ++i
    EFC39831.1 592 IIGDTGSGKSTLISSII 608
                   89**********99988 PP

  == domain 2  score: 8.0 bits;  conditional E-value: 0.0026
                    SEEEE--TTSSHHHHHHHH CS
  FtsK_SpoIIIE   41 hllvaGatgsGKStalntL 59  
                     + v+G+tgsGKSt l +L
    EFC39831.1 1192 KIGVVGRTGSGKSTLLISL 1210
                    6779**********99776 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.1   0.0      0.01       6.2       4      24 ..     592     612 ..     590     637 .. 0.86
   2 ?    5.1   0.1      0.04        25       1      36 [.    1192    1228 ..    1192    1240 .. 0.67
   3 ?   -1.6   0.0       4.8     3e+03      79     119 ..    1315    1357 ..    1301    1358 .. 0.59

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.01
                 EESSTTSSHHHHHHCHCT-CC CS
         Roc   4 lvGdsgvGKtsllkrfvedkf 24 
                 ++Gd+g+GK++l+++++ +++
  EFC39831.1 592 IIGDTGSGKSTLISSIIGESI 612
                 89************9997765 PP

  == domain 2  score: 5.1 bits;  conditional E-value: 0.04
                  EEEEESSTTSSHHHHHHCHCT.-CCC-EEETTTTEEE CS
         Roc    1 KvvlvGdsgvGKtsllkrfve.dkfsekekstigvdf 36  
                  K+ +vG +g+GK++ll ++ +  + se + ++ gvd+
  EFC39831.1 1192 KIGVVGRTGSGKSTLLISLFRfIEASEGNITIDGVDI 1228
                  8999***********9887751233334444445555 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 4.8
                  TSCEEEEEEEGHHH...HCHHHHHHHH.HHHCSSS-EEEEEE-TT CS
         Roc   79 eaalailvydsrss...enlkeWlkel.kkvagkspvilvgnkiD 119 
                  +a+  i+++d+++    +n +e ++++ +++ ++s +i v+ ++D
  EFC39831.1 1315 RAK--IIIFDESTAfvdHNSDEIVQKViREEFKESTIITVAHRLD 1357
                  444..4455533321225666666654266778888888988887 PP

>> AAA_25  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.1   0.0     0.012       7.5      29      53 ..     583     607 ..     560     614 .. 0.88
   2 ?    6.5   0.0     0.009       5.6      32      55 ..    1189    1212 ..    1167    1220 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.1 bits;  conditional E-value: 0.012
      AAA_25  29 llpagelallaGapgtGKttlaldl 53 
                 +l +g+l  ++G++g+GK+tl +++
  EFC39831.1 583 ILEKGKLYSIIGDTGSGKSTLISSI 607
                 688999***************9875 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.009
      AAA_25   32 agelallaGapgtGKttlaldlal 55  
                   g+ + ++G++g+GK+tl+++l  
  EFC39831.1 1189 PGTKIGVVGRTGSGKSTLLISLFR 1212
                  57777899************9965 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.6   0.3     0.075        46       6      22 ..     591     607 ..     586     619 .. 0.84
   2 ?    8.4   0.0    0.0027       1.7       3      88 ..    1191    1338 ..    1190    1348 .. 0.75

  Alignments for each domain:
  == domain 1  score: 3.6 bits;  conditional E-value: 0.075
      AAA_24   6 liyGpsgiGKTtlakel 22 
                  i+G+ g+GK+tl++++
  EFC39831.1 591 SIIGDTGSGKSTLISSI 607
                 69************987 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0027
      AAA_24    3 lkiliyGpsgiGKTtlakelgpkplfidtekGlksldadkfpdie....................swedfldevvel.................... 59  
                   ki ++G  g+GK+tl+ +l   + fi   +G   +d+ ++ +i                     +          +                    
  EFC39831.1 1191 TKIGVVGRTGSGKSTLLISL---FRFIEASEGNITIDGVDISQIGlktlrkslliipqipilfsgT----------Irynldpfnefqdheiwkale 1274
                  699*****************...9999999999999999999995555555555555555555442..........044444444446666777777 PP

      AAA_24   60 ...................................aaeladyktlviDtideleelclaevirq 88  
                                                     ++ l++ k++++D  + ++++ ++e+ ++
  EFC39831.1 1275 rvhmkekiqqiglsgnvtengsnfsigerqllslcRCILRRAKIIIFDESTAFVDHNSDEIVQK 1338
                  7777777777788888888899999999999999988999999999999888888888887665 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.8   0.0    0.0067       4.1       3      78 ..     592     668 ..     590     680 .. 0.77
   2 ?    3.8   0.0      0.12        76       3      23 ..    1195    1215 ..    1193    1226 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0067
  RNA_helicase   3 lyGpsgeGKStlakeLa.kallkklklkkkdsvysrnpeddfwdgYtgqevvvidDfgqvkdeenpsdlaelirlvs 78 
                   + G++g GKStl+ +++ +++ ++  lk ++++    ++++ w   ++   ++i+D +   d+e+++ + e+++l +
    EFC39831.1 592 IIGDTGSGKSTLISSIIgESIVSEGSLKVNPQLSLSLCDENPWMINSSVRNNIIFDKSLEFDSEKYNRVLEVCQLKD 668
                   78************966155566666677677766888888888888888888888888877778888888888865 PP

  == domain 2  score: 3.8 bits;  conditional E-value: 0.12
  RNA_helicase    3 lyGpsgeGKStlakeLakall 23  
                    ++G++g GKStl  +L + ++
    EFC39831.1 1195 VVGRTGSGKSTLLISLFRFIE 1215
                    78**********999877665 PP

>> Septin  Septin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       2.3   1.4e+03     144     196 ..     381     435 ..     378     450 .. 0.69
   2 ?    5.5   0.0     0.015       9.1       9      34 ..     592     617 ..     589     640 .. 0.87
   3 ?    4.8   0.1     0.023        14       8      26 ..    1194    1212 ..    1190    1230 .. 0.86

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2.3
                 EEEEESSGGGS-HHHHHHHHHHHHHHHHH..TT--------SSSS-SCCHHHHHH CS
      Septin 144 liPviaKaDtltkeElkefKkkireelee..eeikiyklpdeeededeeakelse 196
                 liPv+aK  t ++  l++f+ +  ++l+e  + i+i k++  ee+ +e+++e  +
  EFC39831.1 381 LIPVLAKILTKVEGWLSKFRDERVKNLNEllNGIRIIKFFVFEEKMKEKVMESRK 435
                 8999999655555558888877777777634579999988888877666555443 PP

  == domain 2  score: 5.5 bits;  conditional E-value: 0.015
                 EEEBTTSSCCCCCCTTSSSS------ CS
      Septin   9 vvGesglGkttlintlfetdlieeek 34 
                 ++G+ g Gk+tli +++ +++++e +
  EFC39831.1 592 IIGDTGSGKSTLISSIIGESIVSEGS 617
                 79***************999998754 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.023
                  EEEEBTTSSCCCCCCTTSS CS
      Septin    8 mvvGesglGkttlintlfe 26  
                   vvG+ g Gk+tl+ +lf+
  EFC39831.1 1194 GVVGRTGSGKSTLLISLFR 1212
                  59***************97 PP

>> AAA_30  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.4   0.0     0.044        27      13      38 ..     583     607 ..     578     620 .. 0.79
   2 ?    6.3   0.0     0.012       7.3      23      49 ..    1195    1221 ..    1188    1245 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.4 bits;  conditional E-value: 0.044
      AAA_30  13 lltsgdrvavltGpAGtGKttalkal 38 
                 +l++g ++  + G  G+GK+t+++++
  EFC39831.1 583 ILEKG-KLYSIIGDTGSGKSTLISSI 607
                 45555.488899**********9987 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.012
      AAA_30   23 ltGpAGtGKttalkalreaweaaggrv 49  
                  ++G+ G+GK+t+l +l + +ea++g++
  EFC39831.1 1195 VVGRTGSGKSTLLISLFRFIEASEGNI 1221
                  79**************99999995444 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.6   0.00014     0.084      18      39 ..     586     607 ..     560     609 .. 0.83
   2 ?   -1.0   0.2       3.5   2.2e+03     141     161 ..     788     808 ..     715     830 .. 0.55
   3 ?    6.4   0.2     0.019        12      24      36 ..    1195    1207 ..    1183    1212 .. 0.87

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 0.00014
      AAA_23  18 skgltlItGpNGaGKTTildAi 39 
                 + +l+ I+G++G+GK+T++  i
  EFC39831.1 586 KGKLYSIIGDTGSGKSTLISSI 607
                 458999************9876 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 3.5
      AAA_23 141 erfeefelkdkkerleeleke 161
                 e+fe++e +dk+e++++  k+
  EFC39831.1 788 EEFENNESNDKEEQVKKDPKS 808
                 223333333333333222111 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.019
      AAA_23   24 ItGpNGaGKTTil 36  
                  ++G +G+GK+T+l
  EFC39831.1 1195 VVGRTGSGKSTLL 1207
                  69**********8 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.1    0.0074       4.5       3      19 ..     591     607 ..     589     689 .. 0.81
   2 ?    5.3   0.7     0.024        15       3      19 ..    1194    1210 ..    1193    1269 .. 0.75
   3 ?   -2.0   0.0       3.9   2.4e+03     236     265 ..    1297    1323 ..    1256    1352 .. 0.79

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0074
      AAA_21   3 vliGpNgsGKSnLLdal 19 
                  +iG+ gsGKS+L+  +
  EFC39831.1 591 SIIGDTGSGKSTLISSI 607
                 59************887 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.024
      AAA_21    3 vliGpNgsGKSnLLdal 19  
                  +++G+ gsGKS+LL  l
  EFC39831.1 1194 GVVGRTGSGKSTLLISL 1210
                  68***********9666 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 3.9
      AAA_21  236 elSdGtkrllalltallralkkgsllliDE 265 
                  ++S G ++ll l   +lr++   +++++DE
  EFC39831.1 1297 NFSIGERQLLSLCRCILRRA---KIIIFDE 1323
                  67889999988888888888...8899988 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   0.0     0.032        20       7      22 ..     596     611 ..     592     658 .. 0.77
   2 ?    4.4   0.1     0.044        27       3      21 ..    1195    1213 ..    1193    1226 .. 0.84

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.032
  Viral_helicase1   7 pGcGKStlirkllrts 22 
                       G+GKStli +++ +s
       EFC39831.1 596 TGSGKSTLISSIIGES 611
                      7***********9985 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.044
  Viral_helicase1    3 vhGvpGcGKStlirkllrt 21  
                       v G  G+GKStl+ +l+r 
       EFC39831.1 1195 VVGRTGSGKSTLLISLFRF 1213
                       56889***********998 PP

>> MeaB  Methylmalonyl Co-A mutase-associated GTPase MeaB
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1     0.084        52      33      57 ..     591     616 ..     570     621 .. 0.76
   2 ?    6.3   0.0    0.0068       4.2      22      56 ..    1183    1217 ..    1170    1230 .. 0.73

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.084
                 EEEE-TTSSHHHHHHHHH.HHHHCTT CS
        MeaB  33 GltGvPGaGkstlvealg.lelrrrG 57 
                  + G  G+Gkstl++ ++ ++++++G
  EFC39831.1 591 SIIGDTGSGKSTLISSIIgESIVSEG 616
                 578999********987514555555 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0068
                  HGGG-S-SEEEEEEE-TTSSHHHHHHHHHHHHHCT CS
        MeaB   22 llakaGraqvvGltGvPGaGkstlvealglelrrr 56  
                  +  +    +++G+ G  G+Gkstl+  l   + + 
  EFC39831.1 1183 IQLEIKPGTKIGVVGRTGSGKSTLLISLFRFIEAS 1217
                  5555556789*************998877666554 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.0    0.0091       5.6      16      50 ..     587     621 ..     576     624 .. 0.82
   2 ?    2.5   0.0      0.12        73      21      50 ..    1195    1224 ..    1186    1230 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0091
  Zeta_toxin  16 PklillgGqpGAGKselaellkdelerqgnvvrld 50 
                  kl+ + G +G+GKs+l++ +  e    ++ ++++
  EFC39831.1 587 GKLYSIIGDTGSGKSTLISSIIGESIVSEGSLKVN 621
                 5788899************9999987666666666 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.12
  Zeta_toxin   21 lgGqpGAGKselaellkdelerqgnvvrld 50  
                  ++G +G+GKs+l+  l + +e+ ++ +++d
  EFC39831.1 1195 VVGRTGSGKSTLLISLFRFIEASEGNITID 1224
                  78*********9988777777666666666 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.2     0.036        22       4      21 ..     591     608 ..     588     620 .. 0.83
   2 ?    5.3   0.2     0.021        13       3      21 ..    1193    1211 ..    1191    1223 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.036
                 EEEESTTCCHHHHHHHHH CS
        cobW   4 vltGflGsGKTtLlnhll 21 
                  + G  GsGK+tL+++++
  EFC39831.1 591 SIIGDTGSGKSTLISSII 608
                 578999*********998 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.021
                  EEEEESTTCCHHHHHHHHH CS
        cobW    3 tvltGflGsGKTtLlnhll 21  
                  ++++G  GsGK+tLl +l 
  EFC39831.1 1193 IGVVGRTGSGKSTLLISLF 1211
                  6799***********9886 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.2     0.037        23       1      16 [.     592     607 ..     592     617 .. 0.90
   2 ?   -1.0   0.3         2   1.2e+03     126     157 ..     946     977 ..     929     987 .. 0.80
   3 ?    6.7   0.0     0.009       5.6       1      24 [.    1195    1218 ..    1195    1225 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.037
  ATP_bind_1   1 vvGpaGsGKttfvgal 16 
                 ++G  GsGK+t+++++
  EFC39831.1 592 IIGDTGSGKSTLISSI 607
                 79***********987 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 2
  ATP_bind_1 126 vvyLvDsqrltdptkfisgllsalsamlrlel 157
                  v+++D+q++    +fi +++s + +++++++
  EFC39831.1 946 DVVVLDTQMIFALPQFITTIISVCFTLVMISI 977
                 58999*******99999999999988877654 PP

  == domain 3  score: 6.7 bits;  conditional E-value: 0.009
  ATP_bind_1    1 vvGpaGsGKttfvgalseilelrg 24  
                  vvG  GsGK+t+  +l  ++e+++
  EFC39831.1 1195 VVGRTGSGKSTLLISLFRFIEASE 1218
                  89**************99999875 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.1      0.11        67       4      21 ..     592     609 ..     590     619 .. 0.83
   2 ?    5.6   0.2     0.022        14       2      34 ..    1193    1227 ..    1192    1239 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.11
                 EE--TTSSHHHHHHHHHH CS
    NTPase_1   4 iTGppGvGKtTlvkkvle 21 
                 i G  G+GK+Tl++ ++ 
  EFC39831.1 592 IIGDTGSGKSTLISSIIG 609
                 6799**********9985 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.022
                  EEEE--TTSSHHHHHHHHHHHH.....GGGEEEEE CS
    NTPase_1    2 vfiTGppGvGKtTlvkkvlellkss..gvkvgGfy 34  
                  + + G+ G+GK+Tl+  + + ++ s  +++++G+ 
  EFC39831.1 1193 IGVVGRTGSGKSTLLISLFRFIEASegNITIDGVD 1227
                  7899***********99999987664578888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1412 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1111  (0.0619666); expected 358.6 (0.02)
Passed bias filter:                      540  (0.0301188); expected 358.6 (0.02)
Passed Vit filter:                        81  (0.00451782); expected 17.9 (0.001)
Passed Fwd filter:                        31  (0.00172904); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              29  [number of targets reported over threshold]
# CPU time: 1.01u 0.35s 00:00:01.36 Elapsed: 00:00:00.51
# Mc/sec: 8310.47
//
Query:       EFC39832.1  [L=703]
Description: long-chain fatty-acid-CoA ligase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      6e-79  265.6   0.0    7.7e-79  265.3   0.0    1.1  1  AMP-binding  AMP-binding enzyme


Domain annotation for each model (and alignments):
>> AMP-binding  AMP-binding enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  265.3   0.0   4.3e-83   7.7e-79       5     422 ..      77     556 ..      73     557 .. 0.84

  Alignments for each domain:
  == domain 1  score: 265.3 bits;  conditional E-value: 4.3e-83
                  HHHSTTSEEEEE......CCSTEEEEHHHHHHHHHHHHHHHHHTTSSTT-EEEEEESSSHHHHHHHHHHHHTT-EEEEEETTS-HHHHHHHHHHHTES CS
  AMP-binding   5 aaktpdkvalvd......sgegqtlTYreldervnrlAagLrslGvkkgdrVaillpnspewvvallailkaGavvvplnptltaeelayiledseak 96 
                   ++ p+++al +       +e+  +T++e++++v+++A+ L++lG+k+g+++ i++ n  ew  ++l++l +++++  ++ ++++ ++ ++l++seak
   EFC39832.1  77 SKQMPNRPALWYknqssqAKEYIPITFKEYNDHVQEVAKSLLALGIKRGETCCIMSGNNKEWNYLDLGCLTVNVICGGIYFSSSELQVLHLLNHSEAK 174
                  67899*****77999999999***************************************************************************** PP

                  EEEETCTCCC.HHHHHHHHSCC-EECEEEEESCCS-HCCHCCCHCCCCSCTTS........................-TSCCCS-BTTSEEEEEEE-- CS
  AMP-binding  97 vliatvdsel.leklleaaakleavklvivldadellkeeelkeeeeseekae........................kpeeeeelkpddlayiiYTSG 169
                  +++  v++++  ek++++ +kl + ++v+ + +  +  +e+lke+ e+  +a                         ++   +++k +d++++iYTSG
   EFC39832.1 175 MVV--VEKKDhFEKVKRCISKLTDLQKVVFINE--SVLNECLKENPEPLLNASgiqvqlwswsdfiklgenitqdqvDE-IFKSIKTNDVCTVIYTSG 267
                  ***..9***************999999888774..34445677776666555257789999************999633.6678999*********** PP

                  SSSS-EEEEEEHHHHHHHHHHHH.HHHCSCCTT.......T-EEEESS-TTSCHHHHHHHHHHHHTT-EEEE-TTCGCCHHHHHHHHHHHHT-SEEEE CS
  AMP-binding 170 TTGkPKGVmlshrnlvanvaslk.letrfklke.......ddvvlsilplahifglilelllallsGatvvllpkdaaldpklllelieklkvtviag 259
                  TTG PK+V+l+ r++++++ ++  + ++ ++++       ++++ls+lplahi++  l ++++l +G +v++++   +     ll++++  ++++++g
   EFC39832.1 268 TTGAPKAVQLTYRAVTSATLAARtIAKYNETHPdfdienhNNTYLSVLPLAHIAERLLTIYIPLRCGYQVYFAESIFT-----LLNDLQVVRPHIFFG 360
                  ***************999999878666655555677777899******************************996644.....689************ PP

                  EHHHHHHH..................HHCCCHHCHHHHC..........................................CGTT-SEEEEESS-EBH CS
  AMP-binding 260 vPrvleal..................lesgalkaakkak..........................................dlsslrlvllggeplsp 297
                  vPr++e++                  +           +                                           + + r++ +g +p+s+
   EFC39832.1 361 VPRIYEKIksgietnlskvnpivrylI-----------QhcmkqvskyntlvamgrstsslldfrakliykfivgplkrkiGFDRTRVFGVGSAPISK 447
                  ********7776655444333333221...........03333334445556666656666655555555555555555554446666889******* PP

                  HHHHHHHHHHTCEEEEEEEEGGGSSECEECHCTTTCTSTTS-BEE-TTEEEEEE-TTTSCBEETTSEEEEEEEETTS-SEBTT-HHHHHHHEEETCCE CS
  AMP-binding 298 ellrffralfgeevlegYGlTEttgvvtvlpleedkkklgsvGkplpgvevkivDeetgepvpdgeeGellvrgpgvmkgYlkkpeataeafdsegrw 395
                  +++ ff+ l    ++++YG +E +++ + ++   +     svG p+pg+e+ki D +          Ge+l++ p++m gY k+++ t+ af+ e+++
   EFC39832.1 448 DVMIFFSGLDAM-LINIYGSSESSAMGSSIR--PRALHFDSVGVPMPGTEIKI-DVD----------GEVLIKAPSTMVGYAKDEKSTKAAFT-EDGF 530
                  *********887.**************8433..33346899************.888..........*************************9.867* PP

                  EEEEEEEEEETTSEEEEEEECCCEEEE CS
  AMP-binding 396 lrTGDlgrldedGyleivgRkkdlikl 422
                  lrTGDlg l+ +G l+i+gRkkd+i +
   EFC39832.1 531 LRTGDLGILR-NGFLKITGRKKDIIMT 556
                  *******999.9************975 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (703 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       855  (0.0476881); expected 358.6 (0.02)
Passed bias filter:                      588  (0.032796); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.75u 0.34s 00:00:01.09 Elapsed: 00:00:00.51
# Mc/sec: 4108.47
//
Query:       EFC39833.1  [L=291]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.3e-21   75.8   0.1    2.1e-21   75.1   0.1    1.3  1  SRF-TF    SRF-type transcription factor (DNA-binding and dime
  ------ inclusion threshold ------
        1.7    9.8   5.9        2.7    9.1   0.2    2.9  3  MRI       Modulator of retrovirus infection


Domain annotation for each model (and alignments):
>> SRF-TF  SRF-type transcription factor (DNA-binding and dimerisation domain)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.1   0.1   2.3e-25   2.1e-21       1      48 []      75     122 ..      75     122 .. 0.99

  Alignments for each domain:
  == domain 1  score: 75.1 bits;  conditional E-value: 2.3e-25
      SRF-TF   1 kIeneraRqvtFsKRrnGLfKKAsELsvLcgvevavvvfspngklytf 48 
                 +I+++++R++tFsKR++G++KKA+ELs+L+g++v ++v s++g++ytf
  EFC39833.1  75 FIQDKSRRHITFSKRKAGIMKKAYELSTLTGTQVLLLVASETGHVYTF 122
                 69*********************************************9 PP

>> MRI  Modulator of retrovirus infection
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.6   0.1     0.032   2.9e+02      23      59 ..      28      64 ..      14      87 .. 0.71
   2 ?    9.1   0.2    0.0003       2.7      28      75 ..     126     179 ..     121     191 .. 0.68
   3 ?   -0.9   0.2       0.4   3.6e+03      70      82 ..     226     238 ..     183     267 .. 0.54

  Alignments for each domain:
  == domain 1  score: 2.6 bits;  conditional E-value: 0.032
         MRI 23 kqekpleqlal.agadkpelspacsespssssgsrsee 59
                +q +++ q+++ aga +  ++ +  esp+ s gs+s  
  EFC39833.1 28 NQGMAMTQMTQgAGATQSTQVTSEVESPPQS-GSNSKK 64
                4445555554425666666666777888888.787765 PP

  == domain 2  score: 9.1 bits;  conditional E-value: 0.0003
         MRI  28 leqlalagadkpelspacsespssss......gsrseeedsgkdapapglspsq 75 
                   q+  + ++ ++l ++c ++p++s+      g++ e+e+  +d  +  ++++q
  EFC39833.1 126 KLQPLITQTEGKNLIQQCLNAPEASQqqmmggGDEDEDEEGDEDEYQGMMGNPQ 179
                 5677788999999************99999634444444444444444444444 PP

  == domain 3  score: -0.9 bits;  conditional E-value: 0.4
         MRI  70 glspsqgpagsds 82 
                 g +++q p+ +++
  EFC39833.1 226 GQGSQQVPQNQNQ 238
                 2333333333222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (291 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1264  (0.0705003); expected 358.6 (0.02)
Passed bias filter:                      369  (0.0205812); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                        11  (0.000613531); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.62u 0.31s 00:00:00.93 Elapsed: 00:00:00.51
# Mc/sec: 1725.63
//
Query:       EFC39834.1  [L=496]
Description: guanine nucleotide-binding protein G(o) subunit alpha [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.5e-43  147.0  13.6      2e-41  142.3  13.6    2.1  1  G-alpha   G-protein alpha subunit


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  142.3  13.6   1.1e-45     2e-41      50     330 ..      74     399 ..      63     490 .. 0.73

  Alignments for each domain:
  == domain 1  score: 142.3 bits;  conditional E-value: 1.1e-45
                 ---HHHHHCCHHHHHHHHHHHHHHHHHHHHHTT.......HHHC-SS-SCCCS-HCHHHH.............HHCCHHC-HCHHHHHHHHC.CSHHHH CS
     G-alpha  50 gfseeelatwraviqlnivrsiktilealesleselsesfelqelkerldplkkveasliaklssateee...qeiefnpraevgedikaLw.ndpgiq 144
                 +f+++   ++ +++ +ni++++k++ + ++++ +++  ++  +++k+++d +k+ +  l  + ss++ ++   +++++++  e++e ++++w ++p+iq
  EFC39834.1  74 SFQTS--TQFLSLLGHNILDQAKKVNDLHTTQVQSI--PIYGNNRKDSVDLSKAPKLVLVGTGSSDSIDNilgDTTFLSD--EICERLVDFWmDEPIIQ 166
                 46655..77999*******************87777..789*****************999888888888**99999999..**********7788*** PP

                 HHHC.CGCCTT--TTHHHHHCT......HHHHCSTT---................-C.................HHHHCS-----SEEEEEEECT-TEE CS
     G-alpha 145 elye.rrnkiklednaeyFldd......leritspdYlp................td.................dDilkarlktvGisetkfevdskle 203
                 ++y   +  +k+ ++ + + ++        r+ + + lp                 d                 + i+ + +kt+Gi+e+ ++++++++
  EFC39834.1 167 MCYFfASIAYKFIEGYGDYSRNraeksvYIRHLNLENLPtlidqledvlsyetegDDlqskfssaikddshivtELIVSTYVKTTGIIEIPVKFGDNNL 265
                 **9864458887566666544444444422333333333333333333333335511555555556656556657777778*************99*** PP

                 EEEEEE-SSHHHHHGTCCCT....TTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHCCCS-GGGCCTT- CS
     G-alpha 204 frivdvgGqrserkkWvpff....ddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKlkkgklskyfpsy 298
                 + ++d+gGqr+erkkW++++    +  + ++Flv+lse++q++yed+++nr+ esl+lF+e++n++ + + p++L+++K+ ++eeKlk  +l+  +p  
  EFC39834.1 266 IGLYDTGGQRNERKKWKNIMndnsQTLSGVLFLVPLSEYNQICYEDDSINRTIESLNLFSELVNRNTFGSLPFFLIFTKKLVMEEKLKLYDLTY-VPFK 363
                 *******************999999999***********************************************************9999986.6766 PP

                 -H.CCHHHHHHHHHH....HHHHCCCCCCESGGSCE CS
     G-alpha 299 egrkndlesvlkylr....nkFeeihkeksnnrrki 330
                 ++ ++dl+ +lk  +    +  ++i+k+k+++  ++
  EFC39834.1 364 TELPQDLKVELKLNEenkkDLLVNILKMKNSQIDNL 399
                 655555555554443222233333333333333333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (496 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       751  (0.0418874); expected 358.6 (0.02)
Passed bias filter:                      383  (0.021362); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.68u 0.31s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 2840.71
//
Query:       EFC39835.1  [L=304]
Description: hypothetical protein NAEGRDRAFT_81159 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
  ------ inclusion threshold ------
      0.076   13.3   0.0       0.14   12.5   0.0    1.3  1  DUF3619      Protein of unknown function (DUF3619)


Domain annotation for each model (and alignments):
>> DUF3619  Protein of unknown function (DUF3619)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   7.7e-06      0.14      55     126 ..     176     249 ..     160     251 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.7e-06
     DUF3619  55 agagasltlgeee....agswlrrlalalpllalvvgLvgiaywqdqqrvaelaeiDaaLLaddLPpaAYlDkgFa 126
                 +g+++++  +  +    ++ ++ +l+  +   ++v+ + +i+ +++++  + + e+D+a+L  +  ++A +D+ F+
  EFC39835.1 176 KGSKKTIDED--NesrpRNVYIGQLHYSIIHTLVVLTFEAISDAEEEEAEEIIVEVDMAILRGEKELDAEADDKFD 249
                 3343433322..1346689999*****999999************************************9999997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (304 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1031  (0.0575046); expected 358.6 (0.02)
Passed bias filter:                      428  (0.0238719); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.62u 0.35s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 1739.49
//
Query:       EFC39836.1  [L=126]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    3.3e-13   50.1   0.0    3.8e-13   49.9   0.0    1.1  1  Rhodanese  Rhodanese-like domain


Domain annotation for each model (and alignments):
>> Rhodanese  Rhodanese-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.9   0.0   2.1e-17   3.8e-13       2     105 ..      15     125 ..      14     126 .] 0.82

  Alignments for each domain:
  == domain 1  score: 49.9 bits;  conditional E-value: 2.1e-17
   Rhodanese   2 akelkellekgkva.....llDvRppeeYek.gh..IpgAvnvskdtlsrakkseapllelpeellel.gidnkktvvvycdgggraaaaaa.llkklG 90 
                  k+lkel+e+ ++      l+DvR+++e +   h  +p Avn+   ++++ ++  + ++e++++ l   + + ++ ++vyc++g r+a a++ l++++G
  EFC39836.1  15 KKQLKELIESSSPSsvkyfLFDVRSEQEANGiFHpiLPTAVNI---PIYHLEPIFEMDDEDFKSQLGIeKPKSDDLIIVYCEHGIRSAMAQQvLIEEYG 110
                 68899999888877889***********444445536******...888888888888888888888888889*************77775537778** PP

   Rhodanese  91 yknvsvldGGfkawk 105
                 y nv +++G+ ++w+
  EFC39836.1 111 YSNVINYRGSAHDWY 125
                 **************8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (126 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       506  (0.0282224); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.50
# Mc/sec: 764.92
//
Query:       EFC39837.1  [L=151]
Description: nucleoside diphosphate kinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-56  187.5   0.0    1.1e-55  187.3   0.0    1.0  1  NDK       Nucleoside diphosphate kinase


Domain annotation for each model (and alignments):
>> NDK  Nucleoside diphosphate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  187.3   0.0   6.1e-60   1.1e-55       1     135 []       4     138 ..       4     138 .. 0.99

  Alignments for each domain:
  == domain 1  score: 187.3 bits;  conditional E-value: 6.1e-60
                 EEEEEEE-HHHHHTT-HHHHHHHHHHHT-EEEEEEEECE-HHHHHHHTGGGTTSTTHHHHHHHHTSSEEEEEEEESTTHHHHHHHHH--SSTTTSSTTS CS
         NDK   1 ertlvliKPdavkrgligeiisrleekglkivalkmlrlteeqaeehYaehkgkpffeelvefmtsgpvvalvlegedaiekvreliGatnpaeaapgt 99 
                 ert++ +KPdav+rglig ii+r+e+kg+k+va+k+++ t e+a++hYaeh gkpff  lvef+tsgpv+a+v+eg+ +i+++r+liG t+p e+apgt
  EFC39837.1   4 ERTFIALKPDAVQRGLIGPIITRFEQKGFKLVAMKLITPTAELASKHYAEHDGKPFFAGLVEFLTSGPVCAMVWEGQGVIAAARKLIGVTKPLESAPGT 102
                 89************************************************************************************************* PP

                 HHHHH-SSSTT-SEEE-SSHHHHHHHHHHHSTGGGS CS
         NDK 100 iRadfgvslgeNlvHgSdseesaereiklfFkeeei 135
                 iR+df++++g+N++HgSds+ sae ei+l+Fk+eei
  EFC39837.1 103 IRGDFAINVGRNIIHGSDSTTSAEAEIALWFKPEEI 138
                 *********************************996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (151 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       247  (0.0137766); expected 358.6 (0.02)
Passed bias filter:                      238  (0.0132746); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.48u 0.27s 00:00:00.75 Elapsed: 00:00:00.47
# Mc/sec: 974.27
//
Query:       EFC39838.1  [L=372]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    9.2e-07   29.0   0.1    2.1e-06   27.8   0.1    1.6  1  Arrestin_N  Arrestin (or S-antigen), N-terminal domain
    9.8e-05   22.8   1.3     0.0034   17.8   0.1    2.3  2  Arrestin_C  Arrestin (or S-antigen), C-terminal domain


Domain annotation for each model (and alignments):
>> Arrestin_N  Arrestin (or S-antigen), N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   27.8   0.1   2.4e-10   2.1e-06      15     138 ..      25     150 ..      14     157 .. 0.82

  Alignments for each domain:
  == domain 1  score: 27.8 bits;  conditional E-value: 2.4e-10
                 T--EEEEEEE-CCCCTT.CEEEEEEEEEEEESSSSTTTTCCCEEEEEEEEEE.EEESTSSSSS.SSSSHHHHHHHH-TTEEEEEE---TTS--SE.... CS
  Arrestin_N  15 getvdGkvlleteelkkarkvkielsgkartgweesevagktfrkdltlkkk.qeyleteksllkskkdsqekLpkGehafpFsfelPknlpsSf.... 108
                  +t++G + le +e+ + + ++i+  + +  g e++e + +  +++l  k++ +++l++e ++ ++      kL kG h+++Fs +lP+++p Sf    
  EFC39838.1  25 SDTIEGDIRLEIKENCN-QVIRIKDITLFLQGLEKLEYQVEGPNRSLAWKSDeKKVLQSEVPIAGD-----GKLTKGPHVYSFSERLPTDIPGSFfeet 117
                 489*************9.9***************99999777666666666537788888887666.....99*************************9 PP

                 ....CSGEEEEEEEEEEEEECCCE--C.CCEEEE CS
  Arrestin_N 109 ....eGkaggvrYevkvtldrpwkidkkkkkvft 138
                     +  + ++ Y+ +++++     +k +++ +t
  EFC39838.1 118 tylgKQIKAQISYFASCVVELRVGNEK-ESQHVT 150
                 9966666789******99987776666.444444 PP

>> Arrestin_C  Arrestin (or S-antigen), C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    3.7   0.1    0.0088        79       5      96 ..      13     114 ..      11     160 .. 0.61
   2 !   17.8   0.1   3.8e-07    0.0034       9     129 ..     184     302 ..     180     306 .. 0.79

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.0088
                 EEEEEEES-SEEETT--EEEEEEEE.E.-SSSEEEEEEEEEE..EEEEEESS.......SEEEEEEEEEEEEE---.B-TTEE.EEEEEEE.----B-- CS
  Arrestin_C   5 vsleaslpkkgyvpGetipvtvkid.n.dskkkvkkikvslv..qhvdvcafnr.....snkkeknvvaksdsvkv.tsaakdkletevelqiPeeltp 93 
                 ++le++l+k++y    + ++ ++i+ n +   ++k i++ l   +++++  +++      +++ek+v++++++     + +k++   +++ ++P+++++
  EFC39838.1  13 INLEIKLQKEWYSDTIEGDIRLEIKeNcNQVIRIKDITLFLQglEKLEYQVEGPnrslaWKSDEKKVLQSEVPIAGdGKLTKGPHVYSFSERLPTDIPG 111
                 7899********655555566666644266688999998775226666666666666643334444444433322246666777776666678877777 PP

                 --- CS
  Arrestin_C  94 ssa 96 
                 s +
  EFC39838.1 112 SFF 114
                 544 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 3.8e-07
                 EEES-SEEETT--EEEEEEEEE-SSSEEEEEEEEEEEEEEEESS..SEEEEEEEEEEEEE---...B-TTEE.EEEEEEE.----B--.....---S-- CS
  Arrestin_C   9 aslpkkgyvpGetipvtvkidndskkkvkkikvslvqhvdvcafnrsnkkeknvvaksdsvkv...tsaakdkletevelqiPeeltp.....ssarnv 99 
                 +s  ++ y+  ++ ++  ++ n+   +v  i+v+l q ++  ++  +++  +n++ +  ++++    ++ kd  ++++ l  P +l       ++ + +
  EFC39838.1 184 ISSRRNIYCRRDKCQFYSEVLNEGISSVSFITVRLLQILKLNME--KQNTSENIMLEVYKKTFngiLPKCKDLRNITFDL-HP-DLVDyflypQT-TYG 277
                 66667777777778888888899999999***************..6666666666666666656688999999988999.99.77766888644.49* PP

                 -EEEEEEEEEEEEEEESSEEEEEEEEEEEE CS
  Arrestin_C 100 elikvsYklkvkltlsgsggelslelPivl 129
                 +li+v+Y l+++l+       +++++Pi +
  EFC39838.1 278 SLIRVEYMLQFSLDNL-----IEINIPIEV 302
                 *************965.....999999976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (372 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       523  (0.0291706); expected 358.6 (0.02)
Passed bias filter:                      333  (0.0185733); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.56u 0.31s 00:00:00.87 Elapsed: 00:00:00.50
# Mc/sec: 2235.16
//
Query:       EFC39839.1  [L=707]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
   1.5e-228  759.9  33.2   1.9e-228  759.6  33.2    1.1  1  HSP90           Hsp90 protein
    2.3e-13   50.6   0.0    4.4e-13   49.7   0.0    1.5  1  HATPase_c       Histidine kinase-, DNA gyrase B-, and HSP90-l
    9.2e-09   35.2   0.0    2.6e-08   33.8   0.0    1.8  1  HATPase_c_3     Histidine kinase-, DNA gyrase B-, and HSP90-l
  ------ inclusion threshold ------
      0.021   14.8   0.1      0.053   13.5   0.1    1.8  1  Cofac_haem_bdg  Haem-binding uptake, Tiki superfamily, ChaN
       0.07   13.0   0.3       0.27   11.2   0.1    2.2  2  ProQ            ProQ/FINO family
        2.7    8.6   7.4        1.1    9.9   0.1    3.7  3  TipAS           TipAS antibiotic-recognition domain
          8    7.0   6.5        4.9    7.7   1.5    2.9  3  GOLD_2          Golgi-dynamics membrane-trafficking


Domain annotation for each model (and alignments):
>> HSP90  Hsp90 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  759.6  33.2  7.4e-232  1.9e-228       1     515 [.     184     698 ..     184     700 .. 0.96

  Alignments for each domain:
  == domain 1  score: 759.6 bits;  conditional E-value: 7.4e-232
                 GGGSHHHHHHHHHHCCTTSSS-EEEEEEEEXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXX..XXXXXXXXXXEEEEEEESXXSXGGGSXGGGSX CS
       HSP90   1 eyleekklkelvkkySeFinfpiyllkekeeekeveeeeeeeeeeeee...eeeeakveeeeeeeeekkktkkvketvkewellNkqkpiWlrkpkevt 96 
                 eylee+klk+lvkk+SeFi +pi+l++ek+eekev+e+++ +++e+++   +e+ +k+ee++e +  +kk+kkvke++ke ellNk+kp+W+r+pk vt
  EFC39839.1 184 EYLEERKLKDLVKKHSEFIGYPISLQVEKTEEKEVDEDDSMSDDEKKDedkKEDGPKIEEVKEVD--DKKKKKVKEVKKELELLNKNKPLWTRDPKTVT 280
                 8***********************************88765555544434477888999998875..79999*************************** PP

                 HHHHHHHHHHTTTTTSXXSEEEEEEEXSSSXEEEEEEEXSSXXTTTTTTTTTSXXTTEEEEETTEEEESXXTTSSXGGGTTXEEEEEESSSXSSSTHHH CS
       HSP90  97 eeeYkeFYkslskdsedplavkhfsaegevefkaiLfvPkrapsdlfekykkkkknnikLYvrrVfitdefedllPkyLsFvkGvvdsddLPLNvsREt 195
                 +eeY++FYk+l++d+e++lavkhfs+eg+ efk++Lf Pkrap+dlfe   kkk nnikLYvr+Vfi+d++e+l+P+yL+FvkG+vds+dLPLN+sRE 
  EFC39839.1 281 KEEYSSFYKALTNDWEEHLAVKHFSVEGNFEFKSLLFTPKRAPFDLFEP--KKKLNNIKLYVRKVFIMDNCEELIPEYLNFVKGIVDSEDLPLNISREH 377
                 ************************************************8..79********************************************** PP

                 HHTCHHHHHHHHHHHHHHHHHHHTSXHHH..HHTHHHHHHHHHHHHHHHXGGGHHHHHTTXEEEET.TEEEEEEEHHHHHHHSXTTXXEEEEEEXSSHH CS
       HSP90 196 lqqnkilkvikkklvrKvlemlkklaeekeeykkfykefsknlklGiiedsanrkklakLlrfkss.kseeeltsLedYvermkekqksiYyiageske 293
                 lqqnki+kvi+k+lv+K++em+++lae+ke++k+fy++f+knlklGi+eds+nr+kla+Llrf+ss +++e++tsL++Y+ermke+q+ iYyi+ges++
  EFC39839.1 378 LQQNKIMKVIRKNLVKKCIEMFTELAENKEDFKTFYEAFGKNLKLGIHEDSQNRQKLAELLRFHSSqTKGEDWTSLKEYIERMKEGQEFIYYITGESRK 476
                 ******************************************************************445679*************************** PP

                 HHHTSGGGHHHHHTTXXEEEEXSTTHHHHHHTXSEETTEEEEETTBSTXXXXXXHHHHHHHHHHHHHHHHHHHHHHHTTTTTESEEEEXSSXSSXSEEE CS
       HSP90 294 evekspflerlkkkgyevlylvdpiDeyvvqqlkeyegkklvnvakegleleeeeeekkkkeelkkkfeeltkllkevlkdkvekvkvserlvdsPcvl 392
                 +v++spf+e+++kkg+evly++dpiDey+vqqlke+egkklv+v+kegl+l+e+eeekkkkeelk++fe+l+kl+k++l+d+vekv+vs+rl dsPc+l
  EFC39839.1 477 AVASSPFIEKCTKKGVEVLYMTDPIDEYMVQQLKEFEGKKLVCVTKEGLKLPETEEEKKKKEELKASFEALCKLMKDILGDRVEKVVVSDRLGDSPCCL 575
                 *************************************************************************************************** PP

                 EBXTTSXXHHHHHHHHHHHHHHHSSTSSSSSXEEEEEXTTSHHHHHHHHHHHHTTTXHHHHHHHHHHHHHHHHHTTXXXSXHHHHHHHHHHHHTTTTHX CS
       HSP90 393 vtseygwsanmerimkaqalrdkskssymsskktleinprhpiikeLkkkveedkedeeakdlaellyetallesGfsledpasfakrierllklslgi 491
                 vt+eygwsanmerimkaqal+d+s++sym skkt+einp+++i++eL+kk+e++k+d++++dl++ll+etall+sGfs+e+p+++a+ri+r++kl+l+i
  EFC39839.1 576 VTGEYGWSANMERIMKAQALKDNSMASYMVSKKTMEINPENSIVNELRKKAEANKADKTVRDLVWLLFETALLTSGFSMEEPHTYASRIHRMIKLGLSI 674
                 *************************************************************************************************** PP

                 XSTTTTTTGGGXGGGXXXXXXXXX CS
       HSP90 492 dedeeveeeeeveeeeeeeeeeee 515
                 de++ ++e++e++++e++ ee+++
  EFC39839.1 675 DEEDLASEKTETTSQENKVEESPA 698
                 999999988888888888777765 PP

>> HATPase_c  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   49.7   0.0   1.7e-16   4.4e-13       1     111 [.      27     181 ..      27     182 .. 0.74

  Alignments for each domain:
  == domain 1  score: 49.7 bits;  conditional E-value: 1.7e-16
                 EHHHHHHHHHHHHHHHHHHH..........HSTTTEEEEEEEEEETEEEEEEEESSSSSTTHHHT.......GTCS.TTCH.....HCSTCHTSTSSSH CS
   HATPase_c   1 gdekrLrqiisnlvdNavkf..........atkageieveikaseddlvisveDnGiGipkedlk.......klfe.kfsq.....ddstkrggggtGl 76 
                 ++e +Lr++isn++d+++k+            +++e+ +++ +++++++++++D+G+G+ k dl        ++++  f++     +d + +g++g+G+
  EFC39839.1  27 NKEVFLRELISNASDALDKIrymsltepsvLDTEKELCIHLIPDKVNKTLTIRDTGCGMAKHDLInclgtvaRSGTkQFMEmlqagADVSLIGQFGVGF 125
                 5799****************8887766543225557777888788***************************888888888987666666666777776 PP

                 .HHHHH.............HH.HHH.HTTTEEEE...EEET..TTEEEEEEEEESS CS
   HATPase_c  77 .Glsiv.............kk.lve.lmgGeiwv...esep..grGttftftlple 111
                  ++++v             ++ ++e   gG++++   es +   rGt+++++++ +
  EFC39839.1 126 ySAYLVadrvvvttkhnddEQyIWEsSAGGSFTItldESGEklSRGTKIVLHMKDD 181
                 64444477666666666664556666677877775452222668899999998865 PP

>> HATPase_c_3  Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.8   0.0     1e-11   2.6e-08       1      99 [.      25     146 ..      25     164 .. 0.81

  Alignments for each domain:
  == domain 1  score: 33.8 bits;  conditional E-value: 1e-11
  HATPase_c_3   1 ysl.ekAlaelvdNsldAdaen................vkievnknrgktgeivieDdGkGmseeelknal.rlatsskeakr.......kstslGkk 73 
                  ys+ e+ l el+ N+ dA  +                   i++  ++  +++++i+D G Gm + +l+n l ++a+s +++         +   +G++
   EFC39839.1  25 YSNkEVFLRELISNASDALDKIrymsltepsvldtekeLCIHLIPDK-VNKTLTIRDTGCGMAKHDLINCLgTVARSGTKQFMemlqagaDVSLIGQF 121
                  566677899********988878899999999999999667766665.479******************7746888877744334433334555**** PP

  HATPase_c_3  74 GiGlklAslslgkkltvitkkegess 99 
                  G+G + ++  +++++ v+tk++++++
   EFC39839.1 122 GVG-FYSAYLVADRVVVTTKHNDDEQ 146
                  ***.999999**********998765 PP

>> Cofac_haem_bdg  Haem-binding uptake, Tiki superfamily, ChaN
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.1   2.1e-05     0.053     157     185 ..     549     608 ..     387     620 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 2.1e-05
                     -..............................TTTHHHHHHHHHHHHHHHHHHHHHHHH.- CS
  Cofac_haem_bdg 157 g..............................eakeealerfveaQvlwDetMAesiaa.a 185
                     +                               + ++++er+++aQ+l+D+ MA+ +++  
      EFC39839.1 549 KlmkdilgdrvekvvvsdrlgdspcclvtgeYGWSANMERIMKAQALKDNSMASYMVSkK 608
                     13333344444457777777777777888777778899****************999742 PP

>> ProQ  ProQ/FINO family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       3.1   7.9e+03      42      64 ..     182     204 ..     172     212 .. 0.74
   2 ?   11.2   0.1    0.0001      0.27      15      73 ..     412     465 ..     382     480 .. 0.84

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 3.1
        ProQ  42 dkeklskkklrkaLktytsslrY 64 
                 + e l+++kl++++k++ +   Y
  EFC39839.1 182 QLEYLEERKLKDLVKKHSEFIGY 204
                 55678889999999998876666 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.0001
        ProQ  15 FPkaFskegeakPLkiGIfedllerladkeklskkklrkaLktytsslrYlkavkegaa 73 
                 F +aF      k Lk+GI+ed ++r++  e l  ++ ++  +++ts ++Y + +keg++
  EFC39839.1 412 FYEAFG-----KNLKLGIHEDSQNRQKLAELLRFHSSQTKGEDWTSLKEYIERMKEGQE 465
                 334444.....56***********88888888888889999***************985 PP

>> TipAS  TipAS antibiotic-recognition domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.6      0.64   1.6e+03      18      52 ..     265     299 ..     233     307 .. 0.63
   2 ?    9.9   0.1   0.00041       1.1      29      83 ..     401     451 ..     398     489 .. 0.77
   3 ?   -0.8   0.1      0.84   2.2e+03      27      49 ..     530     552 ..     521     563 .. 0.73

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.64
                 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXX CS
       TipAS  18 seekiaklskedweelkaelkelfaklaaalaagk 52 
                 ++++   ++ + ++  k+e+  ++++l+++ +++ 
  EFC39839.1 265 LNKNKPLWTRDPKTVTKEEYSSFYKALTNDWEEHL 299
                 33444445666666666777777777777666655 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.00041
                 XXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
       TipAS  29 dweelkaelkelfaklaaalaagkdpdseeaqelaeehralieefwgecskeila 83 
                 +++e k+ +k+++++++++l+ g   ds+  q+lae +r + ++++ge     + 
  EFC39839.1 401 ELAENKEDFKTFYEAFGKNLKLGIHEDSQNRQKLAELLRFHSSQTKGE----DWT 451
                 56788999***********************************87774....222 PP

  == domain 3  score: -0.8 bits;  conditional E-value: 0.84
                 XXXXXXXXXXXXXXXXXXXXX.. CS
       TipAS  27 kedweelkaelkelfaklaaala 49 
                 +e+ +++k+elk+ f++l ++++
  EFC39839.1 530 TEEEKKKKEELKASFEALCKLMK 552
                 56777788888888888877773 PP

>> GOLD_2  Golgi-dynamics membrane-trafficking
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.0       1.5   3.8e+03      33      60 ..     121     148 ..      99     181 .. 0.71
   2 ?    7.7   1.5    0.0019       4.9      31      83 ..     202     256 ..     193     278 .. 0.68
   3 ?    0.1   0.1      0.41     1e+03      24      78 ..     643     697 ..     632     706 .. 0.72

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 1.5
      GOLD_2  33 fGvyfewteatskavsvkvsesddeede 60 
                 fGv f  +   ++ v v   + dde+  
  EFC39839.1 121 FGVGFYSAYLVADRVVVTTKHNDDEQYI 148
                 7887777777777887777777776654 PP

  == domain 2  score: 7.7 bits;  conditional E-value: 0.0019
      GOLD_2  31 iGfGvyfewteatskavsvkvsesddeedeeeeee....eekveeedvekgsvkaak 83 
                 iG+ ++++ ++++ k+v  + s sdde+++e+++e        e ++v+  ++k+ k
  EFC39839.1 202 IGYPISLQVEKTEEKEVDEDDSMSDDEKKDEDKKEdgpkI--EEVKEVDDKKKKKVK 256
                 8999999999*******99999999998888777734221..222222222222222 PP

  == domain 3  score: 0.1 bits;  conditional E-value: 0.41
      GOLD_2  24 fatdeydiGfGvyfewteatskavsvkvsesddeedeeeeeeeekveeedvekgs 78 
                 f t     Gf +   +t a+  +  +k + s deed  +e+ e++++e++ve++ 
  EFC39839.1 643 FETALLTSGFSMEEPHTYASRIHRMIKLGLSIDEEDLASEKTETTSQENKVEESP 697
                 5566666677777777777777777888888899988888888888999988765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (707 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1809  (0.100898); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        65  (0.00362541); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.75u 0.28s 00:00:01.03 Elapsed: 00:00:00.46
# Mc/sec: 4574.49
//
Query:       EFC39840.1  [L=5338]
Description: ATS1 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    7.8e-29  100.1   0.3     0.0017   19.0   0.0   10.2 10  RCC1             Regulator of chromosome condensation (RCC1) 
    1.4e-11   43.8  28.2    2.3e-05   24.0   0.0    7.8 10  RCC1_2           Regulator of chromosome condensation (RCC1) 
    7.7e-09   35.2   6.8    7.7e-09   35.2   6.8    4.5  4  Ephrin_rec_like  Putative ephrin-receptor like
  ------ inclusion threshold ------
       0.16   11.6   2.6       0.45   10.1   2.6    1.7  1  AcrZ             Multidrug efflux pump-associated protein Acr
        1.1    9.2  15.1          1    9.3   2.7    3.3  3  LapA_dom         Lipopolysaccharide assembly protein A domain
        2.8    8.9   7.6         35    5.5   0.1    3.0  2  DUF4834          Domain of unknown function (DUF4834)


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0      0.13   3.8e+02       4      48 ..     175     226 ..     173     227 .. 0.79
   2 !   10.8   0.0   0.00019      0.57       5      33 ..     235     265 ..     232     286 .. 0.75
   3 !   19.0   0.0   5.6e-07    0.0017       1      41 [.     290     329 ..     290     337 .. 0.72
   4 ?    0.8   0.0      0.27     8e+02       2      32 ..     342     375 ..     341     379 .. 0.83
   5 !    9.9   0.0   0.00038       1.1       9      49 ..     699     747 ..     693     748 .. 0.78
   6 !   12.8   0.0   4.5e-05      0.14       2      34 ..     752     787 ..     752     797 .. 0.74
   7 ?    0.3   0.0      0.38   1.1e+03       8      49 ..     985    1038 ..     984    1039 .. 0.66
   8 !   17.0   0.0   2.3e-06    0.0069       1      50 []    1042    1089 ..    1042    1089 .. 0.88
   9 !   10.9   0.0   0.00019      0.55       5      31 ..    1096    1124 ..    1094    1135 .. 0.80
  10 ?   -1.6   0.4       1.5   4.5e+03       5      19 ..    1205    1219 ..    1204    1220 .. 0.92

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.13
                 EEEEE--GGGTTSSSS---E.EEEEE-GGGTTS......-EEEEEEETTEEE CS
        RCC1   4 VysWGrndyGqLGlgttesv.lvPtkveglsgn......rvvkvacGddhtv 48 
                 +y+ G+n y  L l +++s+ + P +++ l++       ++ +  cG++ ++
  EFC39840.1 175 IYGTGSNIYKSLSLSNENSKsNSPIRLTILENFlksqsdWIDQLYCGYSSVF 226
                 8999**********999555488****6666556666989999999998665 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 0.00019
                 EEEE--GGGTTSSSS-..--EEEEEE-GGGT CS
        RCC1   5 ysWGrndyGqLGlgtt..esvlvPtkvegls 33 
                   +Grnd +qLGlg++   ++ +Pt  ++l+
  EFC39840.1 235 IVFGRNDVNQLGLGSEfrANSITPTIHPFLT 265
                 579*************865556798887765 PP

  == domain 3  score: 19.0 bits;  conditional E-value: 5.6e-07
                 TTEEEEEE--GGGTTSSSS-.......--EEEEEE-GGGTTS-EEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt.......esvlvPtkveglsgnrvvkva 41 
                 dG+Vy+ G n+++q+Glg +       ++v++P k+        +k++
  EFC39840.1 290 DGSVYCAGLNNHHQCGLGINeytisnfVQVPIPEKI--------TKIS 329
                 9****************9998776444444556555........4444 PP

  == domain 4  score: 0.8 bits;  conditional E-value: 0.27
                 TEEEEEE--GGGTTSSSS---E...EEEEE-GGG CS
        RCC1   2 GrVysWGrndyGqLGlgttesv...lvPtkvegl 32 
                 G+++s G+n    LG+  t+++   ++P+k+e+l
  EFC39840.1 342 GEILSSGWNLGFILGQNITDENyvsSTPVKIENL 375
                 899999999999****99955537788****987 PP

  == domain 5  score: 9.9 bits;  conditional E-value: 0.00038
                 --GGGTTSSSS-...--E...EEEEE-GGGTTS...-EEEEEEETTEEEE CS
        RCC1   9 rndyGqLGlgtt...esv...lvPtkveglsgn...rvvkvacGddhtva 49 
                  n+y+qLGl +    + +   + P++v++l++n   ++v +   +++t++
  EFC39840.1 699 DNQYNQLGLTDFatrQ-KvyeSQPVLVSLLNNNyhkEIVNIYPSNYFTLF 747
                 69*******8885431.134444********9999999999988888887 PP

  == domain 6  score: 12.8 bits;  conditional E-value: 4.5e-05
                 TEEEEEE--GGGTTSSSS-..--E.EEEEE-GGGTT CS
        RCC1   2 GrVysWGrndyGqLGlgtt..esv.lvPtkveglsg 34 
                 G++++ G+n+++qLG+g++   ++  +P  +e + +
  EFC39840.1 752 GNLFGIGKNTEYQLGIGHNlnIDKfIIPLIIEKPVS 787
                 89*****************55222233777766544 PP

  == domain 7  score: 0.3 bits;  conditional E-value: 0.38
                  E--GGGTTSSSS-......--E..........EEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1    8 GrndyGqLGlgtt......esv..........lvPtkveglsgnrvvkvacGddhtva 49  
                  G n yG LG g          +          l+P  +++    +v+++++G+++ ++
  EFC39840.1  985 GDNFYGELGMGGYssisisT-SnlqlltnnilLLPIYLANE---NVKSITSGNNFIIV 1038
                  78889999996664444331.13444444455558888775...8*******999776 PP

  == domain 8  score: 17.0 bits;  conditional E-value: 2.3e-06
                  TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1    1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtval 50  
                  +G+++s G n +GqLG+ +t s+   tk+e+     +++v+c ++h++al
  EFC39840.1 1042 SGNLFSVGDNRFGQLGQNDTISRYFLTKIESTI--TFTSVTCNSFHCIAL 1089
                  59******************8885667776655..************997 PP

  == domain 9  score: 10.9 bits;  conditional E-value: 0.00019
                  EEEE--GGGTTSSSS-..--EEEEEE-GG CS
        RCC1    5 ysWGrndyGqLGlgtt..esvlvPtkveg 31  
                  y+WG n++GqL l +t  + v +P+++ +
  EFC39840.1 1096 YGWGDNTFGQLCLDSTtkKVVYTPSQIIF 1124
                  9************9996444488**9976 PP

  == domain 10  score: -1.6 bits;  conditional E-value: 1.5
                  EEEE--GGGTTSSSS CS
        RCC1    5 ysWGrndyGqLGlgt 19  
                  y+ G n +G LG g+
  EFC39840.1 1205 YCLGENKFGTLGFGH 1219
                  899*********996 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.6   0.3       1.8   5.3e+03      21      30 .]      71      80 ..      61      80 .. 0.75
   2 ?    1.0   0.0      0.13   3.8e+02      11      26 ..     166     181 ..     163     183 .. 0.92
   3 ?   -2.5   0.0       1.7   5.1e+03       7      30 .]     221     244 ..     217     244 .. 0.76
   4 !   12.6   0.2   3.1e-05     0.092       4      30 .]     277     303 ..     275     303 .. 0.95
   5 ?   -3.4   0.1       3.1   9.2e+03      22      27 ..     402     407 ..     401     408 .. 0.82
   6 ?   -2.0   0.1       1.2   3.5e+03      16      25 ..     592     601 ..     591     606 .. 0.80
   7 ?   -2.0   0.0       1.2   3.5e+03       5      19 ..     966     980 ..     962     980 .. 0.83
   8 !   24.0   0.0   7.8e-09   2.3e-05       1      30 []    1026    1055 ..    1026    1055 .. 0.99
   9 !   19.5   1.4     2e-07   0.00061       2      30 .]    1077    1105 ..    1076    1105 .. 0.97
  10 ?    0.5   0.1      0.19   5.8e+02       4      24 ..    1136    1156 ..    1130    1157 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.6 bits;  conditional E-value: 1.8
      RCC1_2 21 lcWGsNsdGQ 30
                ++ G+N++GQ
  EFC39840.1 71 VGKGDNTVGQ 80
                5569*****9 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.13
      RCC1_2  11 scaLtedGeVlcWGsN 26 
                 +++++ ++e++++GsN
  EFC39840.1 166 TFIILKNQEIYGTGSN 181
                 78999**********9 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 1.7
      RCC1_2   7 GdyHscaLtedGeVlcWGsNsdGQ 30 
                 G++  ++ t  +++  +G+N++ Q
  EFC39840.1 221 GYSSVFIKTKANRIIVFGRNDVNQ 244
                 55555555778999******9988 PP

  == domain 4  score: 12.6 bits;  conditional E-value: 3.1e-05
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +s+G +++++   dG V+c G N++ Q
  EFC39840.1 277 ISFGLNFTLISFKDGSVYCAGLNNHHQ 303
                 9**********************9987 PP

  == domain 5  score: -3.4 bits;  conditional E-value: 3.1
      RCC1_2  22 cWGsNs 27 
                 +WGsN 
  EFC39840.1 402 AWGSNQ 407
                 8****7 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 1.2
      RCC1_2  16 edGeVlcWGs 25 
                 ++++V+ +G+
  EFC39840.1 592 NNNRVYVFGN 601
                 89*******8 PP

  == domain 7  score: -2.0 bits;  conditional E-value: 1.2
      RCC1_2   5 saGdyHscaLtedGe 19 
                  +Gd+++++++ dGe
  EFC39840.1 966 TIGDNFAIFIDYDGE 980
                 68*********9996 PP

  == domain 8  score: 24.0 bits;  conditional E-value: 7.8e-09
      RCC1_2    1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30  
                  Vks+ +G+++ ++Lte+G++++ G+N +GQ
  EFC39840.1 1026 VKSITSGNNFIIVLTESGNLFSVGDNRFGQ 1055
                  89***************************9 PP

  == domain 9  score: 19.5 bits;  conditional E-value: 2e-07
      RCC1_2    2 ksvsaGdyHscaLtedGeVlcWGsNsdGQ 30  
                  +sv ++++H +aL ++++ ++WG+N++GQ
  EFC39840.1 1077 TSVTCNSFHCIALGSNNKYYGWGDNTFGQ 1105
                  699*************************9 PP

  == domain 10  score: 0.5 bits;  conditional E-value: 0.19
      RCC1_2    4 vsaGdyHscaLtedGeVlcWG 24  
                  +s+G + s++ +++G+V ++G
  EFC39840.1 1136 MSIGQNSSIFYSNSGDVIACG 1156
                  57899999999*********9 PP

>> Ephrin_rec_like  Putative ephrin-receptor like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.2      0.35     1e+03       5      21 ..    4631    4647 ..    4627    4651 .. 0.72
   2 !   35.2   6.8   2.6e-12   7.7e-09       8      48 .]    4650    4690 ..    4643    4690 .. 0.91
   3 !    4.6   4.9     0.009        27      14      34 ..    4692    4712 ..    4691    4727 .. 0.82
   4 ?    3.2   1.5     0.025        75      11      32 ..    4768    4786 ..    4762    4792 .. 0.78

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.35
  Ephrin_rec_like    5 ntgletCipCprgtYqn 21  
                       ++ +e C pC++g+ +n
       EFC39840.1 4631 SSFNELCKPCKIGYSKN 4647
                       556788******98665 PP

  == domain 2  score: 35.2 bits;  conditional E-value: 2.6e-12
  Ephrin_rec_like    8 letCipCprgtYqneegqlsClaCPlgtttkkpgatsesdC 48  
                         +C +C rg+Y ++ g+l+C++CP+ +tt  +g+ts++ C
       EFC39840.1 4650 GGPCVACDRGYYASQPGSLECTKCPSLQTTLDTGSTSIDYC 4690
                       479*************************************9 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.009
  Ephrin_rec_like   14 CprgtYqneegqlsClaCPlg 34  
                       Cp  tY  ++ ++sC  CP g
       EFC39840.1 4692 CPSQTYYYNIYKNSCVTCPKG 4712
                       *******************55 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.025
  Ephrin_rec_like   11 CipCprgtYqneegqlsClaCP 32  
                       C +C+ g+Y+++    sC++C 
       EFC39840.1 4768 CGLCEDGFYRSSR---SCSRCS 4786
                       99*******9865...555554 PP

>> AcrZ  Multidrug efflux pump-associated protein AcrZ
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   2.6   0.00015      0.45      14      40 ..    4881    4907 ..    4877    4911 .. 0.89

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00015
        AcrZ   14 MvPvvmAiiLglIygLGEvfNviSkiG 40  
                  ++Pv++ i++ ++y++GE+ N+i k+ 
  EFC39840.1 4881 LIPVMLLILFVVLYLMGELRNIIAKFA 4907
                  79*********************9985 PP

>> LapA_dom  Lipopolysaccharide assembly protein A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   0.3   0.00079       2.4      12      46 ..    5032    5066 ..    5026    5072 .. 0.87
   2 ?   -4.3   0.6       5.6   1.7e+04      27      40 ..    5115    5128 ..    5112    5131 .. 0.80
   3 ?    9.3   2.7   0.00033         1      12      60 ..    5172    5220 ..    5167    5224 .. 0.75

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00079
    LapA_dom   12 faqvelpLsllllvafgiGallgwllslwsylrlr 46  
                  +++v +p s++ ++ fg+Ga + +l s+++y + +
  EFC39840.1 5032 TWWVMFPFSVIYFILFGLGAAAFFLYSAIRYRKVK 5066
                  577799**********************9888766 PP

  == domain 2  score: -4.3 bits;  conditional E-value: 5.6
    LapA_dom   27 fgiGallgwllslw 40  
                  +++G++l++l +++
  EFC39840.1 5115 IALGFVLIFLSFVI 5128
                  68999999998775 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00033
    LapA_dom   12 faqvelpLsllllvafgiGallgwllslwsylrlrrelrrlkkkikkle 60  
                  ++  +l L+l ++++++  a+l++ + +  + r+r+e+++ k+k+++ +
  EFC39840.1 5172 LWIRTLALVLTIIIFVLTAAVLVLAVLWDIRTRKRKEAKKIKEKLEEIK 5220
                  5666889999999999999998888888555588888888888887766 PP

>> DUF4834  Domain of unknown function (DUF4834)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.1     0.012        35       3      64 ..    5179    5234 ..    5174    5249 .. 0.61
   2 ?    3.4   3.9     0.051   1.5e+02      22      74 ..    5265    5317 ..    5261    5332 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.012
     DUF4834    3 fLlfilifiiailviglsilsvilrtvfglgsrkkssksaqkqfgnstnsnqqksqsrsetk 64  
                  ++l i+if+++ +v++l++l+ i  +      rk++ k+ +++ ++ +ns ++ ++++s  k
  EFC39840.1 5179 LVLTIIIFVLTAAVLVLAVLWDIRTRK-----RKEA-KKIKEKLEEIKNSISNGTTDKSDDK 5234
                  567777888888888888887775444.....3333.3555555555555555554444443 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.051
     DUF4834   22 lsvilrtvfglgsrkkssksaqkqfgnstnsnqqksqsrsetkeegeiieeer 74  
                  ++ ++ ++f+l +rkk++++ ++++++ +++ ++k++s+se+++++++ + ++
  EFC39840.1 5265 INDVFSNLFSLERRKKKTDKIKQKGAKIKSKITNKTKSTSEKTNGDDSFDYSD 5317
                  7889**************99999888888888888887777777766655444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (5338 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1372  (0.0765241); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 1.91u 0.35s 00:00:02.25 Elapsed: 00:00:00.58
# Mc/sec: 27605.65
//
Query:       EFC39841.1  [L=527]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00012   22.4  16.8      0.053   14.0   4.6    6.2  8  LRR_4     Leucine Rich repeats (2 copies)
     0.0093   15.7  11.2        0.9    9.3   3.9    4.3  3  LRR_8     Leucine rich repeat
  ------ inclusion threshold ------
      0.016   15.3   6.7      0.032   14.4   1.6    3.4  3  FNIP      FNIP Repeat
       0.03   14.0   1.0       0.47   10.1   0.1    2.9  3  DUF1699   Protein of unknown function (DUF1699)
      0.066   13.3   7.1        4.3    7.6   0.0    4.9  5  LRR_6     Leucine Rich repeat


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.0     0.014        50       6      33 ..     202     233 ..     198     238 .. 0.69
   2 !    6.2   0.8    0.0042        15       2      15 ..     341     354 ..     332     362 .. 0.63
   3 !   14.0   4.6   1.5e-05     0.053       2      36 ..     341     374 ..     340     380 .. 0.83
   4 !   12.5   0.9   4.1e-05      0.15       2      32 ..     363     394 ..     362     398 .. 0.81
   5 ?   -1.8   0.0       1.3   4.8e+03      18      30 ..     405     418 ..     401     439 .. 0.69
   6 ?   -0.3   0.0      0.47   1.7e+03      21      33 ..     434     445 ..     411     460 .. 0.71
   7 ?    2.5   0.2     0.058   2.1e+02       8      33 ..     446     473 ..     436     481 .. 0.63
   8 ?    2.2   0.0     0.074   2.7e+02      19      37 ..     484     502 ..     463     508 .. 0.72

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.014
                 EE--SS---E-S-HH.....H-TT--EEE-..-S CS
       LRR_4   6 LdLsnNqltdiplle.....klpnLkeLdL.sgN 33 
                 Ld+++  + ++p+l       +pn ++++L s N
  EFC39841.1 202 LDIAG--IETFPSLInelvlMCPNIEHVNLgSYN 233
                 55666..66667733456677*********5556 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0042
                 S--EEE--SS---E CS
       LRR_4   2 nLevLdLsnNqltd 15 
                 +Le+L L+ N++++
  EFC39841.1 341 KLEKLVLNENNIKE 354
                 56777777666664 PP

  == domain 3  score: 14.0 bits;  conditional E-value: 1.5e-05
                 S--EEE--SS---E-S-HHH-TT.--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpn.LkeLdLsgNnli 36 
                 +Le+L L+ N++++ +++++lp+ L+ LdL +N++i
  EFC39841.1 341 KLEKLVLNENNIKE-GNIQSLPHsLTCLDL-SNTQI 374
                 8************6.458889999******.66576 PP

  == domain 4  score: 12.5 bits;  conditional E-value: 4.1e-05
                 S--EEE--SS---E-S-.HH.H-TT--EEE-.- CS
       LRR_4   2 nLevLdLsnNqltdipl.le.klpnLkeLdLsg 32 
                 +L+ LdLsn+q+ d  l +  +lp+Lk+L L +
  EFC39841.1 363 SLTCLDLSNTQIPDNFLqIVaSLPQLKSLGL-N 394
                 89***********966652257******988.4 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 1.3
                 -HHH-TT.--EEE- CS
       LRR_4  18 lleklpn.LkeLdL 30 
                  l +l++ L+eL++
  EFC39841.1 405 HLVGLKHtLEELHI 418
                 45667777888887 PP

  == domain 6  score: -0.3 bits;  conditional E-value: 0.47
                 H-TT--EEE-.-S CS
       LRR_4  21 klpnLkeLdLsgN 33 
                 ++ +Lk L L  N
  EFC39841.1 434 QIESLKRLFL-MN 445
                 4778888887.33 PP

  == domain 7  score: 2.5 bits;  conditional E-value: 0.058
                 --.SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   8 Ls.nNqltdipl..leklpnLkeLdLsgN 33 
                 Ls + q+ d ++  l+kl+nL+ + L  +
  EFC39841.1 446 LSqD-QINDTGGyeLAKLKNLEIVGLEYC 473
                 3333.466655655668999998877555 PP

  == domain 8  score: 2.2 bits;  conditional E-value: 0.074
                 HHH-TT--EEE-.-S---- CS
       LRR_4  19 leklpnLkeLdLsgNnlit 37 
                  +++pn k++++ g+ +i+
  EFC39841.1 484 AASCPNIKKIHIDGCHNIK 502
                 347********98876665 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.4   0.1       1.2   4.2e+03       3      28 ..     283     308 ..     276     310 .. 0.63
   2 !    9.3   3.9   0.00025       0.9       2      57 ..     341     394 ..     340     395 .. 0.91
   3 !    7.6   0.1   0.00086       3.1      21      60 ..     435     474 ..     432     475 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.4 bits;  conditional E-value: 1.2
                 -SEEE-TTS--SEE-TTSSTT-TT-- CS
       LRR_8   3 LtsLdLsnNrltslddeaFkglsnLk 28 
                 L++L+L +      + ea  +++nLk
  EFC39841.1 283 LEKLVLKCETSVICCHEAILNWKNLK 308
                 66666666655555666666666666 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00025
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLs 57 
                 +L++L+L+ N++++ + ++    ++L+ LdLsn ++     +  ++Lp+L+sL L+
  EFC39841.1 341 KLEKLVLNENNIKEGNIQSLP--HSLTCLDLSNTQIPDNFLQIVASLPQLKSLGLN 394
                 799********9999999998..79************98899**********9985 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.00086
                 STT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS- CS
       LRR_8  21 FkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNr 60 
                  ++l++L  ++Ls+ +++      ++ L++L+   L+++ 
  EFC39841.1 435 IESLKRLFLMNLSQDQINDTGGYELAKLKNLEIVGLEYCY 474
                 5789****************************99999876 PP

>> FNIP  FNIP Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.8   0.0     0.078   2.8e+02       9      26 ..     209     235 ..     203     239 .. 0.74
   2 ?   14.4   1.6   8.9e-06     0.032      13      43 ..     341     371 ..     306     372 .. 0.94
   3 ?   -3.1   0.0       2.6   9.4e+03      31      42 ..     384     394 ..     378     396 .. 0.70

  Alignments for each domain:
  == domain 1  score: 1.8 bits;  conditional E-value: 0.078
        FNIP   9 eLP..........snleiLilgrdFnqk 26 
                 ++P          +n+e+ +l  ++nqk
  EFC39841.1 209 TFPslinelvlmcPNIEHVNL-GSYNQK 235
                 555555555566689******.788887 PP

  == domain 2  score: 14.4 bits;  conditional E-value: 8.9e-06
        FNIP  13 nleiLilgrdFnqkiligsLPnSlkeLyFgy 43 
                  le+L l+ +  ++ +i sLP+Sl+ L +++
  EFC39841.1 341 KLEKLVLNENNIKEGNIQSLPHSLTCLDLSN 371
                 69**************************997 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 2.6
        FNIP  31 sLPnSlkeLyFg 42 
                 sLP +lk+L ++
  EFC39841.1 384 SLP-QLKSLGLN 394
                 677.67777664 PP

>> DUF1699  Protein of unknown function (DUF1699)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.0       0.1   3.7e+02      33      63 ..     214     243 ..     211     259 .. 0.74
   2 ?   -2.7   0.0       1.2   4.3e+03      22      44 ..     367     389 ..     331     397 .. 0.56
   3 ?   10.1   0.1   0.00013      0.47      12      53 ..     459     500 ..     456     516 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.1
     DUF1699  33 ilslvkkcpklkaiqvpeSykktlsksakmf 63 
                 i +lv  cp+++ +++  Sy+++    ak++
  EFC39841.1 214 INELVLMCPNIEHVNLG-SYNQKENYHAKQI 243
                 6689999*******997.5655554444444 PP

  == domain 2  score: -2.7 bits;  conditional E-value: 1.2
     DUF1699  22 vHlafrpsntdilslvkkcpklk 44 
                 + l+     +++l++v + p+lk
  EFC39841.1 367 LDLSNTQIPDNFLQIVASLPQLK 389
                 33333333344555555555555 PP

  == domain 3  score: 10.1 bits;  conditional E-value: 0.00013
     DUF1699  12 ietlnenekivHlafr.psntdilslvkkcpklkaiqvpeSyk 53 
                 +++l +n +iv l ++  s++++ s+  +cp++k i++   ++
  EFC39841.1 459 LAKL-KNLEIVGLEYCyISHKTVNSIAASCPNIKKIHIDGCHN 500
                 5566.677899999984599******************88775 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.1      0.58   2.1e+03       4      15 ..     341     352 ..     341     353 .. 0.89
   2 ?    5.2   0.1     0.007        25       3      15 ..     362     374 ..     361     377 .. 0.88
   3 ?    7.6   0.0    0.0012       4.3       3      24 .]     411     433 ..     409     433 .. 0.92
   4 ?   -1.0   0.0      0.72   2.6e+03      14      24 .]     450     460 ..     446     460 .. 0.90
   5 ?   -2.3   0.0       1.8   6.6e+03       1      15 [.     486     501 ..     486     502 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.58
       LRR_6   4 hLteLdLsgNdI 15 
                 +L++L L+ N+I
  EFC39841.1 341 KLEKLVLNENNI 352
                 5999*******9 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.007
       LRR_6   3 thLteLdLsgNdI 15 
                 ++Lt LdLs  +I
  EFC39841.1 362 HSLTCLDLSNTQI 374
                 79*******9998 PP

  == domain 3  score: 7.6 bits;  conditional E-value: 0.0012
       LRR_6   3 thLteLdLsgNd.IgDeGaeaLa 24 
                 ++L+eL+++     gDeG++ ++
  EFC39841.1 411 HTLEELHITQSSsCGDEGVMYIS 433
                 89*****************9875 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 0.72
       LRR_6  14 dIgDeGaeaLa 24 
                 +I+D G+  La
  EFC39841.1 450 QINDTGGYELA 460
                 69*****9987 PP

  == domain 5  score: -2.3 bits;  conditional E-value: 1.8
       LRR_6   1 snthLteLdLsgNd.I 15 
                 s++++++ ++ g++ I
  EFC39841.1 486 SCPNIKKIHIDGCHnI 501
                 5899999999999755 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (527 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       736  (0.0410508); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.60u 0.29s 00:00:00.88 Elapsed: 00:00:00.46
# Mc/sec: 3423.01
//
Query:       EFC39842.1  [L=848]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.9e-07   29.3   0.1    6.3e-06   26.7   0.0    2.3  2  AAA_16           AAA ATPase domain
    0.00011   22.5   1.4    0.00011   22.5   1.4    3.3  4  UPF0231          Uncharacterised protein family (UPF0231)
     0.0012   18.5   0.2     0.0034   17.0   0.2    1.8  1  cobW             CobW/HypB/UreG, nucleotide-binding domain
     0.0074   16.0   0.1      0.017   14.9   0.1    1.6  1  AAA_24           AAA domain
     0.0094   16.5   3.4     0.0094   16.5   3.4    3.4  4  ABC_tran         ABC transporter
  ------ inclusion threshold ------
      0.011   14.8   0.0      0.021   13.9   0.0    1.3  1  T2SSE            Type II/IV secretion system protein
      0.017   14.5   0.7       0.28   10.5   0.0    2.9  3  FtsK_SpoIIIE     FtsK/SpoIIIE family
      0.022   14.7   0.1      0.078   12.9   0.1    2.0  1  NTPase_1         NTPase
      0.024   14.6   0.0      0.088   12.7   0.0    2.0  1  NACHT            NACHT domain
      0.025   13.5   0.6      0.053   12.4   0.0    1.7  2  TrwB_AAD_bind    Type IV secretion-system coupling protein DN
      0.026   14.6   2.3       0.13   12.3   0.3    3.2  2  AAA_14           AAA domain
      0.027   14.7   1.5       0.32   11.2   0.5    3.0  2  AAA_22           AAA domain
      0.039   13.7   0.3        0.1   12.3   0.3    1.7  1  AAA_29           P-loop containing region of AAA domain
      0.065   13.1   2.6       0.13   12.2   0.6    2.6  2  HATPase_c_5      GHKL domain
      0.069   13.6   0.6        1.7    9.1   0.1    3.0  2  AAA              ATPase family associated with various cellul
      0.099   12.5   0.4        0.3   11.0   0.1    2.0  1  MobB             Molybdopterin guanine dinucleotide synthesis
       0.12   12.6   0.0       0.39   10.9   0.0    2.0  1  AAA_33           AAA domain
       0.71   10.3   4.8        1.4    9.4   0.5    3.3  2  MitMem_reg       Maintenance of mitochondrial structure and f
       0.78    9.9   2.9        1.2    9.2   0.0    2.9  3  Sigma54_activ_2  Sigma-54 interaction domain
        5.5    6.7   7.0         15    5.3   0.1    3.0  3  Viral_helicase1  Viral (Superfamily 1) RNA helicase


Domain annotation for each model (and alignments):
>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.7   0.0     7e-09   6.3e-06      25     152 ..      87     278 ..      77     284 .. 0.64
   2 ?   -1.9   0.0       4.3   3.9e+03      59      89 ..     790     820 ..     775     831 .. 0.62

  Alignments for each domain:
  == domain 1  score: 26.7 bits;  conditional E-value: 7e-09
      AAA_16  25 elvllsGesGvGKsslvrellralekd.....................ggiflrgkcdqlesaipysalaqalareellrqlldeaesaeleawrekle 102
                 + vl+ G++G+GK++ + +  r ++++                      +i ++ ++             + + + + +          + +    +le
  EFC39842.1  87 SGVLILGPKGSGKTTFLSKTIRKVREQdsnilendgvhtividlgsikSWIQTYSTT-------------NKFQKASSIY---------LINTLTNQLE 163
                 89***************8888888888899999985544444333332122222222.............2222222222.........2222222222 PP

      AAA_16 103 eala...............................................................avpelagaea.srllellkrll.allsrderp 136
                 ++++                                                               +v+++  +++ +++  +l++++  l+++  ++
  EFC39842.1 164 KEYErfkkkheimlknekvepsttvtssnqeqkpienelttteeeehhetglkavvqvleawveylqEVRNVQEELSeKDISVALAKFMnLLAQNSFSK 262
                 222222222224444555555555666666666666666677888888888998899999999988877777777779999999999996666666667 PP

      AAA_16 137 lvlvlDdlqwadeasl 152
                 +v+++Dd q   e+++
  EFC39842.1 263 TVIFCDDYQEMFEHPQ 278
                 *********9999887 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 4.3
      AAA_16  59 kcdql.esaipysalaqalareellrqlldea 89 
                  +++  e+   ys ++q+l +eel ++++de+
  EFC39842.1 790 YFTEDtERISQYSEYLQQL-EEELKQEENDEL 820
                 4444434446677888888.546666666554 PP

>> UPF0231  Uncharacterised protein family (UPF0231)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.5   1.4   1.2e-07   0.00011      20     120 ..     129     228 ..     114     229 .. 0.85
   2 ?   -2.0   0.1       4.6   4.1e+03      21      66 ..     394     438 ..     388     463 .. 0.63
   3 ?   -1.9   0.0       4.3   3.8e+03      36      80 ..     727     769 ..     723     790 .. 0.54
   4 ?   -0.8   0.1       1.9   1.7e+03      26      56 ..     785     815 ..     776     826 .. 0.75

  Alignments for each domain:
  == domain 1  score: 22.5 bits;  conditional E-value: 1.2e-07
     UPF0231  20 eheaigrWlneevgkdlekiqevlaaieelkasqeeelqlkgkeysllldedevevkanalaleedeeeeleedlslydeesiafCGleDfeelleswq 118
                 +   i +W++++ ++++ + ++ +  i++l ++ e+e++   k+ +++l++++ve ++    ++++e++ +e++l+ ++ee+  + Gl+   ++le+w 
  EFC39842.1 129 DLGSIKSWIQTYSTTNKFQKASSIYLINTLTNQLEKEYERFKKKHEIMLKNEKVEPSTTVT-SSNQEQKPIENELTTTEEEEHHETGLKAVVQVLEAWV 226
                 556678899999888877777777899******9*********************887766.45566688****************************9 PP

     UPF0231 119 ef 120
                 e+
  EFC39842.1 227 EY 228
                 86 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 4.6
     UPF0231  21 heaigrWlneevgkdlekiqevlaaieelkasqeeelqlkgkeysl 66 
                 h+ + + ++e +  +++k+ +  ++ ++l++++  +++++ k +++
  EFC39842.1 394 HKLVKSIFEEKL-GNVRKVIAFQKQKDQLESGEFANITIEDKPFTI 438
                 556666666666.566666677777777777777777777777664 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 4.3
     UPF0231  36 lekiqevlaaieelkasqeeelqlkgkeysll.ldedevevkanal 80 
                 ++++++ ++++++lk++   +++   +++ l+ l++ + +vk+ +l
  EFC39842.1 727 TSNVKNYISVVNSLKSN---NFESVNHHFALFaLEKTHTNVKNYKL 769
                 44445555555555554...44444555554324444444555544 PP

  == domain 4  score: -0.8 bits;  conditional E-value: 1.9
     UPF0231  26 rWlneevgkdlekiqevlaaieelkasqeee 56 
                 ++++++ ++d+e+i++  + +++l+++ ++e
  EFC39842.1 785 SYVEDYFTEDTERISQYSEYLQQLEEELKQE 815
                 5778888888888888888888888874433 PP

>> cobW  CobW/HypB/UreG, nucleotide-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.2   3.7e-06    0.0034       4      38 ..      90     124 ..      88     252 .. 0.87

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 3.7e-06
                 EEEESTTCCHHHHHHHHHCT--SS-EEEEESS-SS CS
        cobW   4 vltGflGsGKTtLlnhllenraglklavivNefge 38 
                 ++ G+ GsGKTt+l++++++ ++++  +++N+  +
  EFC39842.1  90 LILGPKGSGKTTFLSKTIRKVREQDSNILENDGVH 124
                 6889***************************9654 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1   1.9e-05     0.017       5      91 ..      89     175 ..      87     239 .. 0.74

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 1.9e-05
      AAA_24   5 iliyGpsgiGKTtlakel.....gpkplfidtekGlksldadkfpdieswedfldevvelaaeladyktlviDtideleelclaevirqnek 91 
                 +li Gp g+GKTt++++      +++  ++  + G+ ++ ++++ +i+sw++ +++ +++   ++  +++ i t++   e   + +++++e+
  EFC39842.1  89 VLILGPKGSGKTTFLSKTirkvrEQDSNILEND-GV-HTIVIDLGSIKSWIQTYSTTNKF---QKASSIYLINTLTNQLEKEYERFKKKHEI 175
                 79**************99666644444444333.44.44444455566666655555555...44455667777776666666666666665 PP

>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.5   3.4   1.1e-05    0.0094      14      80 ..      89     206 ..      83     265 .. 0.68
   2 ?   -2.4   0.0       6.9   6.2e+03      52      74 ..     403     425 ..     373     486 .. 0.60
   3 ?   -1.6   0.0       3.9   3.5e+03      39      97 ..     571     675 ..     555     685 .. 0.48
   4 ?   -1.0   0.1       2.6   2.4e+03      53      93 ..     794     836 ..     722     843 .. 0.55

  Alignments for each domain:
  == domain 1  score: 16.5 bits;  conditional E-value: 1.1e-05
                 EEEEESTTSSHHHHHHHHTTSS--SEEEE....................................EETTCEGGG........B-HHHCCHCEEEE-SS- CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx....................................xxxxxxxxx........xxxxxxxxxxxxxxxxx RF
    ABC_tran  14 vaivGenGaGKStLlkllagllkpteGei....................................lldgkdlke........qeleslrkeigvlpqep 68 
                 v i+G+ G+GK+t+l+  +++++ +  +i                                    l                +e e+++k+ +++ +++
  EFC39842.1  89 VLILGPKGSGKTTFLSKTIRKVREQDSNIlendgvhtividlgsikswiqtysttnkfqkassiyL-------IntltnqleKEYERFKKKHEIMLKNE 180
                 78**********************999997888888888888888887777776665555555442.......03333334467777777777777777 PP

                 -S-TTSBHHHH..............H CS
                 xxxxxxxxxxx..............x RF
    ABC_tran  69 qlfpeltvren..............e 80 
                 ++ p +tv ++              e
  EFC39842.1 181 KVEPSTTVTSSnqeqkpieneltttE 206
                 88888886665333333333333330 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 6.9
                 B-HHHCCHCEEEE-SS--S-TTS CS
                 xxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  52 qeleslrkeigvlpqepqlfpel 74 
                 ++l  +rk i++ +q++ql ++ 
  EFC39842.1 403 EKLGNVRKVIAFQKQKDQLESGE 425
                 56666677777777776665443 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 3.9
                 EEEEEET.TCEGGG.....B-HHHCCHCEEE.E-SS--S-.TTSBHHHH......................................HHHTCHHHHHHH CS
                 xxxxxxx.xxxxxx.....xxxxxxxxxxxx.xxxxxxxx.xxxxxxxx......................................xxxxxxxxxxxx RF
    ABC_tran  39 eGeilld.gkdlke.....qeleslrkeigv.lpqepqlf.peltvren......................................esdeeiekalsk 91 
                  G+++++ gk+l+      +++ + + ei   l+qep+l+ ++l+v  n                                       sd+++++al++
  EFC39842.1 571 IGKVEYRaGKKLEIlkeklKQRIKPKTEIDAlLEQEPKLDmKGLSVCLNqpsplisffgrdlsdfskgslisikpgsppfnvnihevSSDSQVAEALKS 669
                 344443333333333333333444555554303344444312333333355555555555566666666666666666666666655666666666666 PP

                 STTGGT CS
                 xxxxxx RF
    ABC_tran  92 lglkel 97 
                 +  k+l
  EFC39842.1 670 ICEKDL 675
                 665555 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 2.6
                 -HHHCCHCEEEE-SS--S-TTSBHHHH.....HHHTCHHHHHHHST CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxx.....xxxxxxxxxxxxxx RF
    ABC_tran  53 eleslrkeigvlpqepqlfpeltvren.....esdeeiekalsklg 93 
                 ++e+ ++ +++l+q     +el+ +en      +++ +e+++s++g
  EFC39842.1 794 DTERISQYSEYLQQL---EEELKQEENdelnfGDTNTVEAMMSQMG 836
                 233333333333333...2222222222334444444555555555 PP

>> T2SSE  Type II/IV secretion system protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.9   0.0   2.3e-05     0.021     131     161 ..      88     118 ..      71     123 .. 0.89

  Alignments for each domain:
  == domain 1  score: 13.9 bits;  conditional E-value: 2.3e-05
       T2SSE 131 lilvsGgTgsGKttllyallkeinksderiv 161
                  +l+ G+ gsGKtt+l   + ++ ++d +i+
  EFC39842.1  88 GVLILGPKGSGKTTFLSKTIRKVREQDSNIL 118
                 58999*********************99996 PP

>> FtsK_SpoIIIE  FtsK/SpoIIIE family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.5   0.0   0.00032      0.28      27      57 ..      75     104 ..      60     113 .. 0.75
   2 ?    0.6   0.1      0.34   3.1e+02     100     161 ..     213     275 ..     200     283 .. 0.80
   3 ?   -2.3   0.0       2.5   2.3e+03     115     162 ..     304     351 ..     300     381 .. 0.66

  Alignments for each domain:
  == domain 1  score: 10.5 bits;  conditional E-value: 0.00032
                   TS-EEEEEGGGS-.SEEEE--TTSSHHHHHH CS
  FtsK_SpoIIIE  27 sgnplvldlkkmashllvaGatgsGKStaln 57 
                    + ++v+ + k    +l++G +gsGK+t+l 
    EFC39842.1  75 DDGKVVAPAEKLS-GVLILGPKGSGKTTFLS 104
                   4445555555555.9**************97 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.34
                   -SHHHHHHHHHHHHHHHHHHHHHHHHTT-SSHHHHHHHH.HHHHHTT---B-TT-........ CS
  FtsK_SpoIIIE 100 tdperalraleeLvkemeeryalfreagvrsiaaydgei.aedpldifgdvflvlDnyddlaa 161
                   t+ + ++++le+ v+ ++e+ ++ +e   ++i+++ +++    ++++f   +++ D+y+++ +
    EFC39842.1 213 TGLKAVVQVLEAWVEYLQEVRNVQEELSEKDISVALAKFmNLLAQNSFSKTVIFCDDYQEMFE 275
                   7788999999999999999999999999999999555540556778899999999**998765 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 2.5
                   HHHHHHHHHHHTT-SSHHH.HHHHHHHHHHTT---B-TT-......... CS
  FtsK_SpoIIIE 115 emeeryalfreagvrsiaa.ydgeiaedpldifgdvflvlDnyddlaae 162
                   + ee  +lf+ +++   ++ +++ i    l +++dv+l+l ny++ ++ 
    EFC39842.1 304 ACEEKTNLFKYTNTYRGKSeKHNLINFGRL-SNEDVDLFLENYKKTNEN 351
                   567777788877777777744444444444.467999999999887764 PP

>> NTPase_1  NTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   8.7e-05     0.078       2      29 ..      89     116 ..      88     126 .. 0.88

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 8.7e-05
                 EEEE--TTSSHHHHHHHHHHHH...GGG CS
    NTPase_1   2 vfiTGppGvGKtTlvkkvlellkssgvk 29 
                 v+i Gp G+GKtT+++k ++++++++ +
  EFC39842.1  89 VLILGPKGSGKTTFLSKTIRKVREQDSN 116
                 6789******************998766 PP

>> NACHT  NACHT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   0.0   9.9e-05     0.088       3      29 ..      89     115 ..      87     133 .. 0.89

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 9.9e-05
                 EEEEC-TTTCHHHHHHHHHHHHCTS-S CS
       NACHT   3 vilqGeaGsGKTtLlqklalawaegkl 29 
                 v++ G+ GsGKTt+l k +++ +e++ 
  EFC39842.1  89 VLILGPKGSGKTTFLSKTIRKVREQDS 115
                 799**************9999998875 PP

>> TrwB_AAD_bind  Type IV secretion-system coupling protein DNA-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   5.9e-05     0.053      16      46 ..      87     117 ..      80     135 .. 0.79
   2 ?   -2.5   0.1         2   1.8e+03      91     169 ..     196     275 ..     189     295 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 5.9e-05
  TrwB_AAD_bind  16 qhilivGttGsGKtqalekllrairargdra 46 
                    + +li+G  GsGKt+ l+k +r++r++   +
     EFC39842.1  87 SGVLILGPKGSGKTTFLSKTIRKVREQDSNI 117
                    5789**********************99443 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2
  TrwB_AAD_bind  91 aeiAaalipedggssdpfWaeaartvlaetlrelvrekkksnaallralltadleeLkel.lagteaaalva.eeaertaa 169
                    + i ++l +++++++++   +a  +vl++ ++ l++  ++ +++l ++ ++  l+++ +l ++++++++++  ++ +++++
     EFC39842.1 196 KPIENELTTTEEEEHHETGLKAVVQVLEAWVEYLQEV-RNVQEELSEKDISVALAKFMNLlAQNSFSKTVIFcDDYQEMFE 275
                    5566666677677777777777778888877777777.5555677766555555555554045566666554466666665 PP

>> AAA_14  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.3   0.00014      0.13       5      35 ..      89     119 ..      87     187 .. 0.86
   2 ?   -1.0   0.1       1.8   1.6e+03      51      78 ..     250     275 ..     223     293 .. 0.63

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00014
      AAA_14   5 lvitGaRrvGKTtllkqlikellvkkesily 35 
                 ++i G++ +GKTt+l + i++   ++++il+
  EFC39842.1  89 VLILGPKGSGKTTFLSKTIRKVREQDSNILE 119
                 689****************998866666654 PP

  == domain 2  score: -1.0 bits;  conditional E-value: 1.8
      AAA_14  51 kllelileklke.ekktylflDEiqevpe 78 
                 k+++l+ +   +   kt++f D  qe+ e
  EFC39842.1 250 KFMNLLAQ---NsFSKTVIFCDDYQEMFE 275
                 33333333...234689999999998754 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.5   0.00036      0.32       8      57 ..      89     140 ..      84     306 .. 0.88
   2 ?   -0.7   0.0       1.8   1.6e+03      49      82 ..     793     835 ..     767     839 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 0.00036
      AAA_22   8 lvvtGesGtGKTtllrrlleqldeeakaee..erpevvfvtlpsstsskdll 57 
                 +++ G++G+GKTt l +  ++  e+ +      +++++ ++l s +s+ + +
  EFC39842.1  89 VLILGPKGSGKTTFLSKTIRKVREQDSNILenDGVHTIVIDLGSIKSWIQTY 140
                 5799*********999999987554443336777777777777766776655 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.8
      AAA_22  49 sstsskdllrellralglelka.........erlsseelleal 82 
                 ++t++ + ++e l++l++elk           +++ e++++++
  EFC39842.1 793 EDTERISQYSEYLQQLEEELKQeendelnfgDTNTVEAMMSQM 835
                 4555555566777777777766555578777777777777776 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.3   0.00012       0.1      21      39 ..      86     103 ..      73     106 .. 0.78

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 0.00012
      AAA_29  21 lkgatlltGpsGsGKSTll 39 
                 l+g +l+ Gp GsGK+T+l
  EFC39842.1  86 LSG-VLILGPKGSGKTTFL 103
                 345.9************97 PP

>> HATPase_c_5  GHKL domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.2   0.6   0.00014      0.13       8      80 ..     152     224 ..     147     240 .. 0.87
   2 ?   -1.9   0.0       3.5   3.1e+03      31      56 ..     299     324 ..     294     337 .. 0.80

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00014
  HATPase_c_5   8 vilgnlLdNAieacskieeekrfIrltvrekkksliisieNsyegekkklesskskkeehGiGlksireivkk 80 
                  + l n L N +e   +  ++k++I l+ ++ + s++++ +N+ ++ +++  ++++++e+h +Glk + ++++ 
   EFC39842.1 152 IYLINTLTNQLEKEYERFKKKHEIMLKNEKVEPSTTVTSSNQEQKPIENELTTTEEEEHHETGLKAVVQVLEA 224
                  56789999999986555557*************************9999999999************999876 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 3.5
  HATPase_c_5  31 IrltvrekkksliisieNsyegekkk 56 
                  I++    ++k+ +++ +N+y+g+++k
   EFC39842.1 299 IEFVYACEEKTNLFKYTNTYRGKSEK 324
                  7777788889999999****998765 PP

>> AAA  ATPase family associated with various cellular activities (AAA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.1   0.1    0.0019       1.7       1      31 [.      89     122 ..      89     207 .. 0.75
   2 ?    1.0   0.0      0.57   5.2e+02      47     109 ..     249     305 ..     216     326 .. 0.69

  Alignments for each domain:
  == domain 1  score: 9.1 bits;  conditional E-value: 0.0019
                 EEEESSTTSSHHHHHHHHHHHH...THEEEEEET CS
         AAA   1 vllyGppGtGKTllakavakel...gvefleisg 31 
                 vl+ Gp+G GKT++ +  ++++   ++++le +g
  EFC39842.1  89 VLILGPKGSGKTTFLSKTIRKVreqDSNILENDG 122
                 799***********99999997444233333333 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.57
                 HHHHHHHHHTS.TSEEEEEETGGGHHHHHTTCCCHHHHHHHHHHHHHHHHTTTSSSTEEEEEEE CS
         AAA  47 relfkeakeka.kpsilfiDEidalaksrsgseseeeervvnqLlteldgvkkkeskvivigat 109
                 +++++ + +++ +++++f D+  +++++       +++++  +++++++ +k  + ++ ++ a+
  EFC39842.1 249 AKFMNLLAQNSfSKTVIFCDDYQEMFEHP------QTNKAYFTMFPFIEILKLPD-NIEFVYAC 305
                 334444444456679**********9988......55666666666666665543.35555555 PP

>> MobB  Molybdopterin guanine dinucleotide synthesis protein B
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.1   0.00034       0.3       3      29 ..      90     116 ..      88     120 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00034
        MobB   3 givgksgsGKTtLleklipelkarglr 29 
                  i g +gsGKTt+l+k i+++++++ +
  EFC39842.1  90 LILGPKGSGKTTFLSKTIRKVREQDSN 116
                 68999***************9998866 PP

>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.0   0.00044      0.39       2      32 ..      89     122 ..      89     196 .. 0.72

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00044
      AAA_33   2 vllvGlpGsGKstlaerllkklg...avllssdt 32 
                 vl+ G++GsGK+t++ + ++k       +l+ d 
  EFC39842.1  89 VLILGPKGSGKTTFLSKTIRKVReqdSNILENDG 122
                 6789***********9997665444466666665 PP

>> MitMem_reg  Maintenance of mitochondrial structure and function
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.4   0.5    0.0015       1.4      20      74 ..     202     258 ..     142     284 .. 0.78
   2 ?    0.7   0.3      0.78     7e+02      37      57 ..     795     814 ..     717     835 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.0015
  MitMem_reg  20 stlstglnrqyyslkilqerldlikdYlkkveegelpvnhe.ilrnlqkllnllP.h 74 
                  t++++ ++++++lk + + l+   +Yl++v + + + +++ i   l+k++nll  +
  EFC39842.1 202 LTTTEEEEHHETGLKAVVQVLEAWVEYLQEVRNVQEELSEKdISVALAKFMNLLAqN 258
                 5667777888888999****************7776667776*********999842 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.78
  MitMem_reg  37 qerldlikdYlkkveegelpv 57 
                  er+++ ++Yl+++ee+ l++
  EFC39842.1 795 TERISQYSEYLQQLEEE-LKQ 814
                 46777777788777743.322 PP

>> Sigma54_activ_2  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.7   0.1       3.3     3e+03      76     112 ..       6      42 ..       5      48 .. 0.82
   2 ?    9.2   0.0    0.0014       1.2      21      57 ..      86     123 ..      78     166 .. 0.79
   3 ?   -3.1   0.1       8.5   7.6e+03      80     120 ..     387     426 ..     384     428 .. 0.70

  Alignments for each domain:
  == domain 1  score: -1.7 bits;  conditional E-value: 3.3
                      EE-TT--HHHHHHHHHHHHHHTTTT-EEEEEEEE-TT CS
  Sigma54_activ_2  76 kdiadlskaeqkeLlellakaeksslrlVstsskdle 112
                      + + +ls++ +++ + l+a+   +++r+ s+s+ +l 
       EFC39842.1   6 NTLSKLSSKSLTRQQSLIARFLVEQCRMFSSSGVKLS 42 
                      5677899999999999999988999999999987765 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.0014
                      SS-EEEEEETT--HH.HHHHCC--TTS-EE--SSTTHH CS
  Sigma54_activ_2  21 klpvfltGekGsgke.lvArlLhknsgpwleifvverl 57 
                       + v+++G+kGsgk+ + ++++ k ++++++i + +  
       EFC39842.1  86 LSGVLILGPKGSGKTtFLSKTIRKVREQDSNILENDGV 123
                      567**********97267**********9999765443 PP

  == domain 3  score: -3.1 bits;  conditional E-value: 8.5
                      T--HHHHHHHHHHHHHHTTTT-EEEEEEEE-TTT..----H CS
  Sigma54_activ_2  80 dlskaeqkeLlellakaeksslrlVstsskdleqlleagaf 120
                      d +++ q +L + + +++  ++r V +  k+ +q le+g+f
       EFC39842.1 387 DSKQNYQHKLVKSIFEEKLGNVRKVIAFQKQKDQ-LESGEF 426
                      5567788888888888887788877776666666.666666 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.1     0.016        15       3      39 ..      91     123 ..      89     143 .. 0.69
   2 ?    2.2   3.0      0.14   1.3e+02     112     199 ..     137     232 ..     130     248 .. 0.69
   3 ?   -1.9   0.0       2.6   2.3e+03      82     103 ..     254     275 ..     246     289 .. 0.70

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.016
  Viral_helicase1   3 vhGvpGcGKStlirkllrtsliltvnrptaelltegk 39 
                      + G  G+GK+t + k +r+   +++ + +++l ++g+
       EFC39842.1  91 ILGPKGSGKTTFLSKTIRK---VRE-QDSNILENDGV 123
                      66667*************9...333.44477777776 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.14
  Viral_helicase1 112 ahlpsslshrvgrrttyllpsdvaeilsak..vgteveversgel...kvetepkgqe.kvlvyltftqalkealgvr..evttvhevqGltfd 197
                       + +s++ ++ + +  yl+++++++++++   ++++ e++ ++e      +++++ qe k + ++  t ++ e++     +v  v e++ +  +
       EFC39842.1 137 IQTYSTTNKFQKASSIYLINTLTNQLEKEYerFKKKHEIMLKNEKvepSTTVTSSNQEqKPIENELTTTEEEEHHETGlkAVVQVLEAWVEYLQ 230
                      566788899999999***************8844444444444445664444444444577777777777777666656667777777766666 PP

  Viral_helicase1 198 kV 199
                      +V
       EFC39842.1 231 EV 232
                      66 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 2.6
  Viral_helicase1  82 laalskaklvilfGDplQipfh 103
                      l+a+++ +  ++f+D +Q  f+
       EFC39842.1 254 LLAQNSFSKTVIFCDDYQEMFE 275
                      45666667889999**996555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (848 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2036  (0.113559); expected 358.6 (0.02)
Passed bias filter:                      675  (0.0376485); expected 358.6 (0.02)
Passed Vit filter:                        88  (0.00490825); expected 17.9 (0.001)
Passed Fwd filter:                        21  (0.00117129); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              20  [number of targets reported over threshold]
# CPU time: 0.85u 0.31s 00:00:01.15 Elapsed: 00:00:00.48
# Mc/sec: 5298.35
//
Query:       EFC39843.1  [L=441]
Description: glucokinase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.4e-28   98.6   0.0      9e-28   97.2   0.0    1.5  1  Glucokinase  Glucokinase


Domain annotation for each model (and alignments):
>> Glucokinase  Glucokinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   97.2   0.0     5e-32     9e-28       4     262 ..      53     338 ..      50     351 .. 0.81

  Alignments for each domain:
  == domain 1  score: 97.2 bits;  conditional E-value: 5e-32
  Glucokinase   4 DiGGTkarlalveaeeeelelleiekyasadyasleealqaflaeaeaevkr.pksavlAvAgpvegdeveltNlp...Wviseeelakelgle.ave 96 
                  D+G T++r+a+  + ++e  +  ++k++++  ++l e l  + ++  + vk+  +++ +A Agpv+g++v++tN +     +  ++l ++l  + + +
   EFC39843.1  53 DVGATNTRIAIQFIVNDEDDEVFMTKFPCNTATNLAEHLTFYGKALVKIVKQgSAAGTIALAGPVTGEKVRITNYKendQEFYYSQLTDTLFPAhKNT 150
                  ***********99999999999*********************988555544155599****************752226788899998886554899 PP

  Glucokinase  97 liNDfeavayaiplleaedlvq..lgggk.......kd.....aeapiavlGaGTGLGvallipekerrv.vlasEGGhvdfapes......eeevel 173
                  l+ND+ea  y+i  +++++ ++  +++ +       ++     +++++avl+ GTGLG +l++ ++++++ v++ E+Ghv  a         +e+ e 
   EFC39843.1 151 LLNDLEASCYGIINVGTNNRLHefFCPYDsannfatPQtvrlsDTSEYAVLAMGTGLGTGLIVGASGGKFnVIPLEAGHVHVATPGtnscdfHEDRER 248
                  ************9988776554223333333344441145566999*****************99999988*********998654112222467788 PP

  Glucokinase 174 leilrkkl....grvsaErvlSGpGLvnlyealaaadkleeellepaeiteaalegedplarealelFlailGsvagdlaLkllargGvyiaG 262
                  +e+l++k+      + +E+++SG+GL+  ye+  ++   +++ +++a+i+e    ++d+ +r a+ +  ++l ++a ++a+ + +  Gv++aG
   EFC39843.1 249 IEFLSQKIysgiYPIEYEDICSGRGLEYCYEFEIRNIP-NAQRKNAAQIAESY--STDVHSRDAMITHYRYLMQAAQNIAILIPTCRGVFLAG 338
                  9999999988767899***************9887764.66778999999987..589**********************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (441 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       576  (0.0321267); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.44
# Mc/sec: 2983.41
//
Query:       EFC39844.1  [L=290]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00043   20.9   0.0    0.00097   19.8   0.0    1.6  2  NAD_binding_1  Oxidoreductase NAD-binding domain
  ------ inclusion threshold ------
      0.052   13.7   0.3       0.28   11.3   0.3    2.3  1  NAD_binding_6  Ferric reductase NAD binding domain


Domain annotation for each model (and alignments):
>> NAD_binding_1  Oxidoreductase NAD-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.0         2   1.8e+04      64      78 ..      89     103 ..      69     105 .. 0.62
   2 !   19.8   0.0   1.1e-07   0.00097       7     106 ..     170     271 ..     169     274 .. 0.82

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 2
                    SSCTTTSSSEESSHH CS
  NAD_binding_1  64 sreeagweggkgrvq 78 
                     ++ +++e ++ +vq
     EFC39844.1  89 LDPRNNDENSTKYVQ 103
                    344555666777777 PP

  == domain 2  score: 19.8 bits;  conditional E-value: 1.1e-07
                    GGHHHHHHHHHHHHHCT....TCSEEEEEEEESSGCGSTTHHHHHHHHHHCTTEEEEEEE.ESSCTTTSSSEESSHHHHHHHHHHHHSSTTEEEEE CS
  NAD_binding_1   7 GiaPvrsvlraileeak....dktkvvlvyGnrteedllyreeleelakklpgrlkvvav.vsreeagweggkgrvqdalleellslkkeethvyv 97 
                    Gi+P ++++ +il +++    ++ k++l+y + +++ l +r+ l+ l+   +g+l+v+++ ++ +++ we     +  + +e+l + + +++ +++
     EFC39844.1 170 GISPSFQLMSEILVNSQgnksNQPKIHLYYIVSKSNYL-LRQSLDDLKIPFQGKLEVTTImNKGDKKPWEALSENL--HNIEKLRQNSTSGCPIII 262
                    9*************96679999999*****98877655.7********************7777777785555544..445566666689****** PP

                    ECSHHHHHH CS
  NAD_binding_1  98 CGppgMika 106
                    CG + ++  
     EFC39844.1 263 CGTKDFESN 271
                    **9999865 PP

>> NAD_binding_6  Ferric reductase NAD binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.3   3.1e-05      0.28      12      59 ..     170     215 ..     159     288 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 3.1e-05
                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  NAD_binding_6  12 GitpfisilkdllkkskkealktkkikliwvvressslewfkdvLnel 59 
                    Gi+p   ++ ++l +s++++ +++ki+l+ +v +s+ l  ++++L+ l
     EFC39844.1 170 GISPSFQLMSEILVNSQGNKSNQPKIHLYYIVSKSNYL--LRQSLDDL 215
                    9******************************9877654..44445555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (290 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      315  (0.0175693); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.52u 0.26s 00:00:00.78 Elapsed: 00:00:00.45
# Mc/sec: 1948.77
//
Query:       EFC39845.1  [L=205]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (205 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1009  (0.0562775); expected 358.6 (0.02)
Passed bias filter:                      503  (0.0280551); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.52u 0.31s 00:00:00.83 Elapsed: 00:00:00.49
# Mc/sec: 1246.17
//
Query:       EFC39846.1  [L=776]
Description: aimless RasGEF-like protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-42  144.0   1.6    1.1e-41  143.0   1.6    1.6  1  RasGEF    RasGEF domain
    3.5e-17   62.5   3.9    1.6e-16   60.4   0.1    3.4  4  RasGEF_N  RasGEF N-terminal motif


Domain annotation for each model (and alignments):
>> RasGEF  RasGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  143.0   1.6   1.2e-45   1.1e-41       1     176 [.     528     711 ..     528     712 .. 0.96

  Alignments for each domain:
  == domain 1  score: 143.0 bits;  conditional E-value: 1.2e-45
      RasGEF   1 elAeqltlieaelfskikpeellgsawsked...rspnveaviarfnrlsnwvaseilseeslkkRakviekfikiakecrklnNfnslmailsaLqss 96 
                 elA+q+t+++++l+++i+++ell+++wsk +   rs++v  + ++fn+lsnw + +i++e+sl++R   ++k++kia  +++lnNfnslma  s  +ss
  EFC39846.1 528 ELAKQITFMDHNLYRNIEAHELLNCSWSKPKlrhRSKHVLLSSEFFNKLSNWFSCQIITEDSLRERKAKLTKLMKIAVAMFRLNNFNSLMALNSVYSSS 626
                 79***************************998755599************************************************************* PP

      RasGEF  97 pvsrLkktweavskkslktleeleelmspennfknyrealkssasskpciPflglyltdltfieegnpdtl.....egk.iNfeKr 176
                  v+rLk +  ++++ ++k +++   +ms++++ k+yr+ +k++a + p   +lg+yltdlt+ie+gnpd +     +   iN++Kr
  EFC39846.1 627 GVFRLKYAIGEIDEGTKKDFTDAIAVMSNDSSSKRYRTYIKQEA-KPPLNIYLGIYLTDLTMIEDGNPDVIkhpktQRSlINWKKR 711
                 *******************************************5.888889******************99****96667*****8 PP

>> RasGEF_N  RasGEF N-terminal motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.0   0.0         2   1.8e+04      91     102 ..      29      40 ..      25      69 .. 0.67
   2 ?   -3.0   0.0         1     9e+03      40      51 ..     258     276 ..     254     319 .. 0.52
   3 !   60.4   0.1   1.8e-20   1.6e-16       2      99 ..     373     459 ..     372     464 .. 0.88
   4 ?    2.3   0.1     0.022     2e+02      23      49 ..     463     490 ..     458     605 .. 0.78

  Alignments for each domain:
  == domain 1  score: -4.0 bits;  conditional E-value: 2
    RasGEF_N  91 dfsddkallskl 102
                 +f++d+++l+++
  EFC39846.1  29 NFTTDSQTLKQF 40 
                 455555555443 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 1
    RasGEF_N  40 eLlekLierye.......i 51 
                  Ll+++ +++        i
  EFC39846.1 258 ALLQLIYQHFAqrglyktI 276
                 5666666666544443331 PP

  == domain 3  score: 60.4 bits;  conditional E-value: 1.8e-20
    RasGEF_N   2 vkagtlekLierLtskrlldddfletFLltyrsFttpaeLlekLieryeinppnnlesdesnswnsksssnirlrvlsvlkewvenhyy.dfsddkall 99 
                 ++++tl+kLie+Lts+   d +f++ FL+tyrsFt p+ Ll+kL +ry+++++  ++++           +i+lr+  ++++w+e++++ d+++++ ++
  EFC39846.1 373 LRGATLNKLIEKLTST-SADGKFIQCFLVTYRSFTVPEILLQKLCQRYRVPKSIPESEK----------VQIQLRTGVIFNKWIEEYFSlDWNENM-IR 459
                 689*************.66779**************************88777777777..........469*****************9999995.44 PP

  == domain 4  score: 2.3 bits;  conditional E-value: 0.022
    RasGEF_N  23 dfletFLltyrsFttp.aeLlekLiery 49 
                  f+e+FLl yr   +  ++L +kL++  
  EFC39846.1 463 VFIEDFLLKYRKLAKMgEKLKQKLAQKL 490
                 699********98764134555555555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (776 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1005  (0.0560544); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.29s 00:00:00.98 Elapsed: 00:00:00.48
# Mc/sec: 4903.89
//
Query:       EFC39847.1  [L=290]
Description: Hypothetical protein NAEGRDRAFT_72267 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      0.006   16.4   0.1      0.012   15.5   0.1    1.5  1  F-box     F-box domain
     0.0072   17.1   0.1      0.015   16.1   0.1    1.6  1  Stm1_N    Stm1
  ------ inclusion threshold ------
      0.059   13.2   1.5        3.1    7.6   0.0    3.2  3  AHD       ANC1 homology domain (AHD)
       0.28   11.3   1.5        8.8    6.5   0.4    2.8  2  HTH_22    HTH domain


Domain annotation for each model (and alignments):
>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.5   0.1   2.7e-06     0.012      10      31 ..      60      81 ..      31      93 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.5 bits;  conditional E-value: 2.7e-06
                HHHHHHHTS-HHHHHHHCTT-H CS
       F-box 10 vlrhILerLplsdllalrrVSk 31
                ++  +Le+Lpl+dll+++ V k
  EFC39847.1 60 LWFIVLEFLPLRDLLRCSVVNK 81
                7888****************98 PP

>> Stm1_N  Stm1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   0.1   3.4e-06     0.015       3      14 ..       2      16 ..       1      50 [. 0.55

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 3.4e-06
      Stm1_N  3 skNlFDLLGdD...d 14
                skN FDLLGdD   +
  EFC39847.1  2 SKNQFDLLGDDslvK 16
                9**********4441 PP

>> AHD  ANC1 homology domain (AHD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   0.0    0.0007       3.1      15      35 ..     105     125 ..     103     131 .. 0.91
   2 ?    2.8   0.0     0.023     1e+02       4      25 ..     141     161 ..     139     166 .. 0.86
   3 ?   -2.2   0.1      0.82   3.7e+03      36      45 ..     274     283 ..     270     283 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0007
         AHD  15 sltdrkvlqrivdiIeetGly 35 
                 + +d+k++ +iv+ I +tG +
  EFC39847.1 105 NENDKKEMGKIVKNIDNTGVF 125
                 679****************98 PP

  == domain 2  score: 2.8 bits;  conditional E-value: 0.023
         AHD   4 eeLkeLqkklmsltdrkvlqri 25 
                 ++L+ +++++m+  d + ++ri
  EFC39847.1 141 QKLQTIKNTIMQEPD-SKMKRI 161
                 689************.778888 PP

  == domain 3  score: -2.2 bits;  conditional E-value: 0.82
         AHD  36 eitestfDFD 45 
                 + t+ +f+FD
  EFC39847.1 274 NTTSHSFEFD 283
                 567899***9 PP

>> HTH_22  HTH domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.0      0.03   1.4e+02      21      39 ..     108     126 ..      92     127 .. 0.80
   2 ?    6.5   0.4     0.002       8.8       5      48 ..     168     211 ..     164     221 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.03
      HTH_22  21 tkeekieivraLdekGiFl 39 
                 +k+e  +iv++ d+ G+F 
  EFC39847.1 108 DKKEMGKIVKNIDNTGVFA 126
                 6788889***********6 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.002
      HTH_22   5 iieevladlgkpverltkeekieivraLdekGiFllkgavekvA 48 
                 +iee +++++ ++e l+++ +  ++++L +k + ++k  v+++A
  EFC39847.1 168 AIEEEIESVQEEAELLKQHVRSFLIEKLSKKKTENMKTKVKECA 211
                 7999999************************9999999999998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (290 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1378  (0.0768587); expected 358.6 (0.02)
Passed bias filter:                      494  (0.0275531); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.55u 0.29s 00:00:00.84 Elapsed: 00:00:00.47
# Mc/sec: 1871.71
//
Query:       EFC39848.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.3e-09   35.9   0.2    1.2e-08   34.7   0.1    1.6  2  BtpA      BtpA family
  ------ inclusion threshold ------
        3.2    7.1  11.8        7.4    6.0  11.8    1.6  1  zf-RanBP  Zn-finger in Ran binding protein and others


Domain annotation for each model (and alignments):
>> BtpA  BtpA family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0      0.31   2.8e+03      28      50 ..      94     116 ..      91     121 .. 0.82
   2 !   34.7   0.1   1.3e-12   1.2e-08     168     232 ..     219     284 ..     196     303 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.31
        BtpA  28 idkAvkeakaleegGvDavilen 50 
                 + +A+k+ak l +  vD++ l n
  EFC39848.1  94 VAHALKNAKLLYDHHVDGLFLIN 116
                 567999999999999**998766 PP

  == domain 2  score: 34.7 bits;  conditional E-value: 1.3e-12
        BtpA 168 vergladavilsGkatGgevdleelklaketvk.vkvlvgsGvseenlekllsiadGvivgtsikk 232
                 +  + +d ++ sG atG + + e+lk+ +e+vk  +  + sGv+++nl   ++ ad +ivgt+i +
  EFC39848.1 219 IASSYVDVILTSGEATGMQIKEEKLKKFTELVKcNPLGIASGVTNKNLITSIKHADVFIVGTYIEH 284
                 356899999************************88999*************************975 PP

>> zf-RanBP  Zn-finger in Ran binding protein and others
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0  11.8   0.00082       7.4       4      27 ..      30      53 ..      29      56 .. 0.90

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.00082
                SEE-SSS--EEESSSSB-TTT--B CS
    zf-RanBP  4 dWdCskClvqNfawstkCvaCqap 27
                 W+C++C+ qN  +   C++C++ 
  EFC39848.1 30 EWTCPSCSHQNQKSYKCCENCSFQ 53
                5********************875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1238  (0.0690501); expected 358.6 (0.02)
Passed bias filter:                      536  (0.0298957); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.45
# Mc/sec: 2110.89
//
Query:       EFC39849.1  [L=130]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.4e-20   73.2   0.4      3e-20   72.9   0.4    1.1  1  NFACT-R_1    NFACT protein RNA binding domain
    4.8e-07   29.9   0.1    9.6e-07   29.0   0.0    1.5  1  NFACT-R_2    NFACT protein RNA binding domain
  ------ inclusion threshold ------
      0.027   14.4   0.1      0.048   13.6   0.1    1.3  1  Baculo_IE-1  Baculovirus immediate-early protein (IE-0)


Domain annotation for each model (and alignments):
>> NFACT-R_1  NFACT protein RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   72.9   0.4     5e-24     3e-20       1     105 [.       1     105 [.       1     109 [. 0.88

  Alignments for each domain:
  == domain 1  score: 72.9 bits;  conditional E-value: 5e-24
   NFACT-R_1   1 kvfwFkssdg.ylvimGkDkqeneelikkyleesdvwfhvdkessahvylrlsege..leeipeelleeaaqlakanSiagnklssvdvvyvpasnlsk 96 
                 +v+ +++sd+ yl+i+G++++en+++ +++ ++ d+wfh +  ss+hv+l++++ +   ++ p++++  a+ l+ka+S++++ + + +v+y p + ++ 
  EFC39849.1   1 MVVQYQTSDNqYLIIVGENAKENDKIRQEASQN-DLWFHLEDVSSPHVILKPNNSSssSSSFPAQAIYYAGVLCKAYSKQKATQ-TSSVIYAPRKSVKT 97 
                 89999988888**************99999777.*****************766665445********************9999.9**********998 PP

   NFACT-R_1  97 tapldtGsv 105
                  +++  G+v
  EFC39849.1  98 VKEI-DGRV 105
                 8874.4555 PP

>> NFACT-R_2  NFACT protein RNA binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.0   0.0   1.6e-10   9.6e-07       8      86 ..      10      96 ..       7     106 .. 0.82

  Alignments for each domain:
  == domain 1  score: 29.0 bits;  conditional E-value: 1.6e-10
   NFACT-R_2  8 ekaklIvgReeeEnkflkgll.kkdfvslrakshkGplvlid........gelseedlelaarivarYskgkeeeevevkvkkkegee 86
                +++ +Ivg +++En+++++ + ++d++ ++ +++++p v+++         ++ ++ +  a  ++  Ysk+k +++ +v ++ +++ +
  EFC39849.1 10 NQYLIIVGENAKENDKIRQEAsQNDLW-FHLEDVSSPHVILKpnnsssssSSFPAQAIYYAGVLCKAYSKQKATQTSSVIYAPRKSVK 96
                6788*****************999999.*************75555443333446788999999***********9999998766655 PP

>> Baculo_IE-1  Baculovirus immediate-early protein (IE-0)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.1     8e-06     0.048      32      90 ..      68     126 ..      63     129 .. 0.90

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 8e-06
  Baculo_IE-1  32 vndycckklvkklkaaldelleeseksleviklinervqvlnvflekklyqcnicedts 90 
                     + ck++ k+++++  +++   +ks++++k i+ rv+v    +++k+y+ +  ++t 
   EFC39849.1  68 YAGVLCKAYSKQKATQTSSVIYAPRKSVKTVKEIDGRVEVKGHVEKMKVYRDDTIKETL 126
                  55678************************************999999***998888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       967  (0.053935); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.42u 0.29s 00:00:00.71 Elapsed: 00:00:00.43
# Mc/sec: 897.92
//
Query:       EFC39850.1  [L=2047]
Description: B-lectin domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    2.2e-55  184.7 285.9    2.7e-05   24.5   7.6   17.7 17  EGF_2         EGF-like domain
    1.4e-09   38.2   0.7      4e-09   36.8   0.7    1.8  1  RGS           Regulator of G protein signaling domain
  ------ inclusion threshold ------
      0.013   16.1   0.0       0.74   10.4   0.0    3.6  3  B_lectin      D-mannose binding lectin


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   4.0   5.9e-05      0.35       5      26 ..      45      65 ..      41      70 .. 0.76
   2 !   18.1  12.5   4.4e-07    0.0027       6      32 .]     213     238 ..     209     238 .. 0.91
   3 !   16.6  11.9   1.2e-06    0.0075       5      32 .]     252     278 ..     243     278 .. 0.91
   4 !    6.2   8.1    0.0022        13       7      32 .]     293     318 ..     288     318 .. 0.89
   5 !   12.3  10.1   2.9e-05      0.17       6      32 .]     332     357 ..     329     357 .. 0.91
   6 !   17.9   9.2   4.8e-07    0.0029       6      32 .]     371     396 ..     367     396 .. 0.92
   7 !   12.6  11.0   2.2e-05      0.13       5      32 .]     409     435 ..     401     435 .. 0.89
   8 !   17.4  11.4     7e-07    0.0042       6      32 .]     449     474 ..     445     474 .. 0.92
   9 !   18.4   8.6   3.6e-07    0.0021       5      32 .]     487     513 ..     483     513 .. 0.86
  10 !   21.0  11.7   5.4e-08   0.00032       5      32 .]     526     552 ..     518     552 .. 0.90
  11 !   22.2   7.4   2.3e-08   0.00014       5      32 .]     565     591 ..     562     591 .. 0.91
  12 !   13.4   6.9   1.3e-05     0.076       4      32 .]     603     630 ..     599     630 .. 0.90
  13 !   16.9  11.4     1e-06    0.0061       6      32 .]     645     670 ..     640     670 .. 0.89
  14 !   22.3   8.1   2.1e-08   0.00012       5      32 .]     683     709 ..     675     709 .. 0.91
  15 !   19.9   8.6   1.2e-07    0.0007       4      32 .]     721     748 ..     717     748 .. 0.91
  16 !   24.5   7.6   4.4e-09   2.7e-05       6      32 .]     763     788 ..     758     788 .. 0.91
  17 !   15.8   9.7   2.3e-06     0.014       5      32 .]     801     827 ..     793     827 .. 0.88

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5.9e-05
       EGF_2  5 deiCgghGtCvnqcGqCdC.dsg 26
                ++ CgghG C ++   C+C d +
  EFC39850.1 45 SNVCGGHGFCQSTD-SCYCvD-S 65
                689*******9777.7***53.3 PP

  == domain 2  score: 18.1 bits;  conditional E-value: 4.4e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++C+ghG+C++    C+C++gy+G +C
  EFC39850.1 213 NACNGHGSCNSRD-SCSCNNGYSGSQC 238
                 68********888.6************ PP

  == domain 3  score: 16.6 bits;  conditional E-value: 1.2e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ghGtC +++  C+C  gy G  C
  EFC39850.1 252 GTVCNGHGTCTAPN-TCQCTGGYNGTFC 278
                 688********999.9***********9 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.0022
       EGF_2   7 iCgghGtCvnqcGqCd.CdsgyqGktC 32 
                 +C+g GtC +++  C  C +g++G  C
  EFC39850.1 293 ACSGFGTCSSPN-TCTnCLAGRYGSEC 318
                 7********999.9*66*********9 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 2.9e-05
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+g+G C +++ +C C+  y+G++C
  EFC39850.1 332 NVCSGRGECGSKN-NCTCSEPYFGDNC 357
                 57*******8777.8************ PP

  == domain 6  score: 17.9 bits;  conditional E-value: 4.8e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghG C +++ +C C+ gy+G +C
  EFC39850.1 371 LVCSGHGACSSPE-NCTCQEGYFGENC 396
                 68***********.8************ PP

  == domain 7  score: 12.6 bits;  conditional E-value: 2.2e-05
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C g G C ++   C+Cd +++Gk C
  EFC39850.1 409 SNVCTGFGNCTAFD-SCQCDEQHYGKFC 435
                 789********999.7************ PP

  == domain 8  score: 17.4 bits;  conditional E-value: 7e-07
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ hG+C++++ +C Cd +y+G +C
  EFC39850.1 449 SVCSSHGQCNSFN-NCTCDENYSGQNC 474
                 57********999.8************ PP

  == domain 9  score: 18.4 bits;  conditional E-value: 3.6e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g+GtC +  ++C+C++ ++G +C
  EFC39850.1 487 SSVCSGRGTCSAY-NNCSCSAPFYGSDC 513
                 789*******955.58************ PP

  == domain 10  score: 21.0 bits;  conditional E-value: 5.4e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 d+ C+ hG+C++++ +C C++gy+G+ C
  EFC39850.1 526 DSSCSSHGSCDSPN-NCTCKPGYYGNRC 552
                 789********999.8************ PP

  == domain 11  score: 22.2 bits;  conditional E-value: 2.3e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+ hG+C +++ +C+C++g++G+ C
  EFC39850.1 565 SGVCSTHGQCLSPN-NCFCEAGFYGPEC 591
                 568********999.8************ PP

  == domain 12  score: 13.4 bits;  conditional E-value: 1.3e-05
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C +hG C +++ +C+C+ gy+  +C
  EFC39850.1 603 SSNVCFQHGACLSPN-NCSCQEGYFSFDC 630
                 4789********999.8********9999 PP

  == domain 13  score: 16.9 bits;  conditional E-value: 1e-06
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghG+C  ++ +C C+sgy+G +C
  EFC39850.1 645 NVCNGHGSCPYPN-NCTCQSGYYGYQC 670
                 78*******8788.8*********999 PP

  == domain 14  score: 22.3 bits;  conditional E-value: 2.1e-08
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+ hG+C +++ +C+C++gy+G+ C
  EFC39850.1 683 STVCSTHGQCLSPN-NCFCEAGYYGPEC 709
                 568********999.8************ PP

  == domain 15  score: 19.9 bits;  conditional E-value: 1.2e-07
       EGF_2   4 sdeiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 s++ C +hGtC +++ +C+C+ gy+G +C
  EFC39850.1 721 SSNVCFQHGTCLSPN-NCSCQEGYYGFDC 748
                 4789********999.8************ PP

  == domain 16  score: 24.5 bits;  conditional E-value: 4.4e-09
       EGF_2   6 eiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 + C+ghG+C  +  +C C +gy+GktC
  EFC39850.1 763 NVCNGHGSCFVPD-NCTCHPGYYGKTC 788
                 68*******9899.8************ PP

  == domain 17  score: 15.8 bits;  conditional E-value: 2.3e-06
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 ++ C+g G+C +++ +C+C +g++ k+C
  EFC39850.1 801 SNVCSGKGQCLSPN-NCSCVDGFTNKDC 827
                 789********999.8************ PP

>> RGS  Regulator of G protein signaling domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.8   0.7   6.7e-13     4e-09       4     117 ..    1887    2026 ..    1884    2027 .. 0.90

  Alignments for each domain:
  == domain 1  score: 36.8 bits;  conditional E-value: 6.7e-13
                  HHHTSHHHHHHHHHHHHHTTCTHHHHHHHHHHHHHTSSHHHHHHHH...HHHHHHHHTSTTSTTSSTS-HHHHHHHHHHHCSS.............. CS
         RGS    4 slledqpgrslFreFlesefseenlsFwlaveefkkakeqeelkkk...akeIyneylapsspkelnidkklreelekrleke.............. 83  
                  + le++ g +lF +F+e+efs+enl ++ +++     ++ e+l      a++Iy++y++++++ e+ni++k r+   +  ek               
  EFC39850.1 1887 NTLESEEGYELFANFCEKEFSSENLFLFSDIKASPDVASGENLGGLlffAERIYEKYIKTGAEMEVNIPSKSRTAFVQLYEKCkkvetnsslellds 1983
                  679999*************************999888666665555566*************************999998888899*********** PP

                  ..........STTTTTTHHHHHHHHHHHHHHHHHHHHTSHHHHH CS
         RGS   84 ..........qpsrklfeeaqeevfellekdsypkFlkselylr 117 
                            +  +++f+ + ++v   l  d +++F+ ++ y +
  EFC39850.1 1984 nslaksgietNIVKDCFDLMMRQVVMNL-GDTFSRFVFTPEYVN 2026
                  *************************999.699*****9999976 PP

>> B_lectin  D-mannose binding lectin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   0.0   0.00012      0.74      13      63 ..      89     140 ..      81     149 .. 0.75
   2 ?    0.4   0.0      0.16   9.6e+02      18      42 ..     161     185 ..     155     195 .. 0.80
   3 ?   -1.9   0.0      0.83   4.9e+03      41      77 ..    1967    2001 ..    1946    2009 .. 0.75

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.00012
    B_lectin  13 kdssgvlkisedgnLvllnesksvvwstssssssa.kntvaqLldsGnLvle 63 
                 ++s+ +lk ++dgnLv++++s  vv+s s+ ++++ +  +++L+ +G L ++
  EFC39850.1  89 TNSQFELKQQNDGNLVVYTRSGGVVFSFSTWQQTPdTPYTLVLSGDGTLQVK 140
                 56777899999***********999998555555505556999999999983 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.16
    B_lectin  18 vlkisedgnLvllnesksvvwstss 42 
                 +l +++dgn+vl+ ++++v + + +
  EFC39850.1 161 KLLVQNDGNIVLYGAQREVCFASGT 185
                 688999******9999999998833 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 0.83
    B_lectin   41 ssssssakntvaqLldsGnLvlesssnseevlWqsfd 77  
                  ++ ++ ++n++++Llds  L+   s  +++++ + fd
  EFC39850.1 1967 EKCKKVETNSSLELLDSNSLAK--SGIETNIVKDCFD 2001
                  567788899999****999987..7777777777777 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (2047 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1488  (0.082994); expected 358.6 (0.02)
Passed bias filter:                      450  (0.025099); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 1.13u 0.30s 00:00:01.43 Elapsed: 00:00:00.49
# Mc/sec: 12581.94
//
Query:       EFC39851.1  [L=337]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      9e-44  149.6   2.2    1.2e-43  149.3   2.2    1.1  1  DUF5565          Family of unknown function (DUF5565)
  ------ inclusion threshold ------
      0.042   13.5   0.2      0.064   12.9   0.2    1.3  1  Methyltransf_28  Putative S-adenosyl-L-methionine-dependent m
       0.12   12.4   0.0       0.29   11.2   0.0    1.7  1  DUF3663          Peptidase


Domain annotation for each model (and alignments):
>> DUF5565  Family of unknown function (DUF5565)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  149.3   2.2   1.9e-47   1.2e-43       5     279 ..      18     314 ..      14     332 .. 0.76

  Alignments for each domain:
  == domain 1  score: 149.3 bits;  conditional E-value: 1.9e-47
     DUF5565   5 gsvqqkipcvfvtevkeepsrkrekqsfkvlateevnkkale....advkkavatekvdGtcvyvttykGkpylwarldrkPnkqaekrfkkfq....k 95 
                  +vq ki+c+f++e  e++         kvla +++ kk+++    +d  +  +t k+dGtc++v +    + l+ r+drk n    k+ k+fq    +
  EFC39851.1  18 FPVQTKISCLFEIEFLEKEK--------KVLAVNRLYKKVVNlptnSDDIRVNPTIKIDGTCCLVRQ----EKLFKRYDRKLNASGSKKNKQFQkeisQ 104
                 579***********998653........345555444444331111343445699**********85....66*********************77555 PP

     DUF5565  96 skkeskeftwnveedfkevPeswipakevkrk...dGkplPdesGhiPGwvPveknnkqycwhssvv.dyeae.valvlres...aeeedlleitavpl 186
                 ++ +++ +++++++dfke P+ wip  ++ +    + ++   +s h+ Gw+Pv+ n     whss++   + e  a++l +    ++e+ ++ +   +l
  EFC39851.1 105 GTADTNILQFDISKDFKEGPKGWIPCDSIAHLfteENNSNVVSSQHLVGWIPVDSNDAADKWHSSAIvSINNEpHAIMLIPYfdqNDEQAKFSVEFRKL 203
                 567778999*****************9999852213444455678******************9975233332256666554222566778899999** PP

     DUF5565 187 eelleqtleliGtnvnanPyglGskkkPvhllvphGalk.........iknaPaldfqellswfqeake..gkveGivwhc....edG....tliklhr 266
                 + l++qtleliG+++n+n y++ +++k  h+lvphG  +         ++n  +l  ++l swf+  ++  +k eGiv+h     e+G    +lik+hr
  EFC39851.1 204 SSLENQTLELIGSKINGNVYNFPANEK-QHFLVPHGWASyswkasnafLENVKELTVEKLKSWFEDESNimSKSEGIVFHImyktEEGkdkeMLIKIHR 301
                 **********************98766.6*******643222233333678899999*******8766533899****996333344433337****** PP

     DUF5565 267 hhlGlkwPvedtl 279
                 hhl l wP +   
  EFC39851.1 302 HHLNLDWPLKGSA 314
                 ********98765 PP

>> Methyltransf_28  Putative S-adenosyl-L-methionine-dependent methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.2   1.1e-05     0.064     101     229 ..     141     310 ..      79     313 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 1.1e-05
  Methyltransf_28 101 eetgfilanEffDaLPihqfertedgw.rellveltpe...........kkakekefrlt...lspsetdplsevlpklskrlka......... 170
                      +  +++ ++ ++  +P+++     d+w    +v++++e           +++++ +f  +   ls  e+++l+ + +k++ ++ +         
       EFC39851.1 141 NNSNVVSSQHLVGWIPVDSND-AADKWhSSAIVSINNEphaimlipyfdQNDEQAKFSVEfrkLSSLENQTLELIGSKINGNVYNfpanekqhf 233
                      566677777777777888777.556674677888888899999999987666666665443355777777888888888888777999999999 PP

  Methyltransf_28 171 .leegsrieispeaeallediaerlak...............egGaaLiiDYgesssepngtLrairkhklv.d.pl 229
                       ++ g+ ++   +++a+le+++e+  +               ++G+++ i Y +++++ ++ L +i++h+l+ d pl
       EFC39851.1 234 lVPHGWASYSWKASNAFLENVKELTVEklkswfedesnimskSEGIVFHIMYKTEEGKDKEMLIKIHRHHLNlDwPL 310
                      999999999999999999999999988899999999999999************99**************9876565 PP

>> DUF3663  Peptidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.2   0.0   4.8e-05      0.29       6      61 ..     158     217 ..     154     225 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.2 bits;  conditional E-value: 4.8e-05
                 ESS---GGG-TT-SEEE-SS-EEEE-....-SS-HHHHHHHHHHHHHHTT--EEEE-SS- CS
     DUF3663   6 seqaaaaaWgekAllsfneegatihl....lekdelraiqrAaRkldgqgikeveLaGeg 61 
                  ++ aa++W + A++s+n+e   i l    +++de ++     Rkl +   +++eL G++
  EFC39851.1 158 DSNDAADKWHSSAIVSINNEPHAIMLipyfDQNDEQAKFSVEFRKLSSLENQTLELIGSK 217
                 677899**************99999766657779999999999******99999999985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (337 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       819  (0.0456802); expected 358.6 (0.02)
Passed bias filter:                      498  (0.0277762); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.49u 0.26s 00:00:00.75 Elapsed: 00:00:00.44
# Mc/sec: 2326.36
//
Query:       EFC39852.1  [L=541]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (541 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       574  (0.0320152); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        27  (0.00150594); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 3507.52
//
Query:       EFC39853.1  [L=184]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.085   12.9   0.0       0.13   12.3   0.0    1.3  1  NLPC_P60  NlpC/P60 family


Domain annotation for each model (and alignments):
>> NLPC_P60  NlpC/P60 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.3   0.0   7.1e-06      0.13      23      82 ..      97     155 ..      91     175 .. 0.66

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 7.1e-06
                 HHHTT.T----SSHHHHCCCSEE..EEG.GG--TTEEEEESGTGGESEEEEEEETTEEEEEE CS
    NLPC_P60  23 afaka.gielprssgeqeaagkkkeisk.selkrGDLvffktkkgisHvgiYlgngkmlhas 82 
                 a++ +   +lp +    ++    k++++  +++ GD++++++    + vgiY+g+gk++ a 
  EFC39853.1  97 AYKLVgKSNLPLDEDGYYESSSVKKVPRyGDFNYGDVLVTNG---GNTVGIYVGDGKIVYAI 155
                 555554455555555554444444444315788899888888...999*********98764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (184 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       650  (0.0362541); expected 358.6 (0.02)
Passed bias filter:                      564  (0.0314574); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.24s 00:00:00.64 Elapsed: 00:00:00.39
# Mc/sec: 1413.61
//
Query:       EFC39854.1  [L=154]
Description: polyubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.4e-68  226.6   6.6    8.6e-34  115.1   0.7    2.0  2  ubiquitin      Ubiquitin family
    5.9e-34  115.7   6.8    1.8e-16   59.7   0.7    2.0  2  Rad60-SLD      Ubiquitin-2 like Rad60 SUMO-like
    9.9e-13   48.4   2.2    8.2e-05   23.0   0.2    3.2  2  Ubiquitin_2    Ubiquitin-like domain
    7.9e-09   35.8   1.1     0.0038   17.5   0.2    2.1  2  Ubiquitin_5    Ubiquitin-like domain
    9.6e-09   35.1   0.4     0.0048   16.8   0.1    2.2  2  TBK1_ULD       TANK binding kinase 1 ubiquitin-like domain
    6.8e-08   32.6   0.7       0.02   15.0   0.1    2.8  2  Rad60-SLD_2    Ubiquitin-2 like Rad60 SUMO-like
    1.4e-06   28.8   0.1      0.038   14.5   0.2    2.1  2  DUF2407        DUF2407 ubiquitin-like domain
      4e-06   26.8   8.6        1.8    8.7   0.2    4.0  4  Ubiquitin_4    Ubiquitin-like domain
    5.4e-06   26.3   0.0        0.1   12.4   0.0    2.1  2  Sde2_N_Ubi     Silencing defective 2 N-terminal ubiquitin dom
     0.0028   17.8   0.2        3.5    7.9   0.0    2.2  2  DUF3861        Domain of Unknown Function with PDB structure 
     0.0079   16.6   0.1        8.8    6.8   0.0    3.0  3  DUF2870        Protein of unknown function (DUF2870)
     0.0083   15.9   0.7        4.3    7.3   0.1    2.4  2  ACT_5          ACT domain
  ------ inclusion threshold ------
      0.017   15.3   0.4        7.6    6.8   0.1    2.2  2  YcgR_2         Flagellar protein YcgR
      0.021   14.9   1.8        6.2    7.0   0.1    2.2  2  ProRS-C_2      Prolyl-tRNA synthetase, C-terminal
      0.035   14.3   2.2        6.9    7.0   0.2    2.4  2  Tash_PEST      Tash protein PEST motif
      0.039   14.0   0.0         12    6.0   0.0    2.3  2  RBD            Raf-like Ras-binding domain
      0.046   13.8   1.2        0.8    9.9   0.1    2.5  3  UDP-g_GGTase   UDP-glucose:Glycoprotein Glucosyltransferase
      0.047   14.2   0.3         13    6.3   0.0    2.3  2  UN_NPL4        Nuclear pore localisation protein NPL4
      0.073   12.9   0.1         13    5.6   0.0    2.2  2  DUF1866        Domain of unknown function (DUF1866)
      0.088   12.6   1.0         19    5.1   0.0    3.0  4  NETI           NETI protein
       0.15   12.4   1.7         31    5.0   0.1    3.2  2  FERM_f0        N-terminal or F0 domain of Talin-head FERM
       0.16   10.6   3.7        5.9    5.4   0.4    2.9  3  Plexin_cytopl  Plexin cytoplasmic RasGAP domain
       0.22   11.3   1.7         17    5.3   0.1    2.3  2  PI3K_p85B      PI3-kinase family, p85-binding domain
       0.32   10.6   1.1         24    4.6   0.1    2.3  2  HAMP_N3        HAMP N-terminal domain 3


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  115.1   0.7   1.2e-36   8.6e-34       1      72 []       3      74 ..       3      74 .. 0.99
   2 !  115.1   0.7   1.2e-36   8.6e-34       1      72 []      80     151 ..      80     151 .. 0.99

  Alignments for each domain:
  == domain 1  score: 115.1 bits;  conditional E-value: 1.2e-36
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72
                i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC39854.1  3 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 74
                9********************************************************************986 PP

  == domain 2  score: 115.1 bits;  conditional E-value: 1.2e-36
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC39854.1  80 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 151
                 9********************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.7   0.7   2.4e-19   1.8e-16       1      72 []       1      71 [.       1      71 [. 0.98
   2 !   59.7   0.7   2.4e-19   1.8e-16       1      72 []      78     148 ..      78     148 .. 0.98

  Alignments for each domain:
  == domain 1  score: 59.7 bits;  conditional E-value: 2.4e-19
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72
                ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC39854.1  1 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 71
                89************************************.******************************986 PP

  == domain 2  score: 59.7 bits;  conditional E-value: 2.4e-19
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC39854.1  78 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 148
                 89************************************.******************************986 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.9   0.2   1.2e-07     9e-05      16      80 ..      13      69 ..       2      70 .. 0.86
   2 !   23.0   0.2   1.1e-07   8.2e-05      15      80 ..      89     146 ..      78     147 .. 0.85

  Alignments for each domain:
  == domain 1  score: 22.9 bits;  conditional E-value: 1.2e-07
                 EEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2 16 serrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80
                  +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC39854.1 13 ITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 69
                 55667899************************99........5667899*********9999995 PP

  == domain 2  score: 23.0 bits;  conditional E-value: 1.1e-07
                  EEEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2  15 sserrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                    +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC39854.1  89 TITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 146
                  556678899************************99........5667899*********9999995 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.1   5.5e-06    0.0041      32      93 ..      11      73 ..       4      77 .. 0.85
   2 !   17.5   0.2   5.1e-06    0.0038      32      93 ..      88     150 ..      79     154 .] 0.85

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 5.5e-06
  Ubiquitin_5 32 kkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93
                 k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+l
   EFC39854.1 11 KTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLRL 73
                 55678888888999999**********************************999875466665 PP

  == domain 2  score: 17.5 bits;  conditional E-value: 5.1e-06
  Ubiquitin_5  32 kkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                  k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+l
   EFC39854.1  88 KTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLRL 150
                  55678888888999999**********************************999875467765 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.1   6.5e-06    0.0049      19      53 ..      17      51 ..       4      71 .. 0.86
   2 !   16.8   0.1   6.5e-06    0.0048      19      53 ..      94     128 ..      80     147 .. 0.86

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 6.5e-06
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53
                +++++t++++  +++++  i++++Q l+f g++l 
  EFC39854.1 17 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 51
                6899****************************973 PP

  == domain 2  score: 16.8 bits;  conditional E-value: 6.5e-06
    TBK1_ULD  19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 +++++t++++  +++++  i++++Q l+f g++l 
  EFC39854.1  94 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 128
                 7899****************************973 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.0   0.1   2.6e-05      0.02      12      87 ..      10      71 ..       1      74 [. 0.72
   2 !   15.0   0.1   2.6e-05      0.02      12      87 ..      87     148 ..      78     151 .. 0.72

  Alignments for each domain:
  == domain 1  score: 15.0 bits;  conditional E-value: 2.6e-05
                 S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2 12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87
                 G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+
   EFC39854.1 10 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVL 71
                 66.6667788889999999998.....5566644..34559****************965433......3566665 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 2.6e-05
                  S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                  G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+
   EFC39854.1  87 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVL 148
                  66.6667788889999999998.....5566644..34559****************965433......3566665 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.2   5.1e-05     0.038      14      68 ..      13      63 ..       6     110 .. 0.70
   2 !   13.4   0.0   0.00012     0.088      14      64 ..      90     136 ..      80     147 .. 0.81

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 5.1e-05
     DUF2407 14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslasslklp 68
                ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++   ++
  EFC39854.1 13 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSDYNIQK 63
                566666..6789999999999987..67777789**************9754444 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 0.00012
     DUF2407  14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslass 64 
                 ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++ 
  EFC39854.1  90 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSDY 136
                 566666..7789999999999987..77777789************99874 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.2    0.0024       1.8       1      32 [.       1      32 [.       1      36 [. 0.94
   2 ?    6.4   0.0     0.012       9.1      58      86 ..      43      70 ..      39      73 .. 0.84
   3 !    8.7   0.2    0.0024       1.8       1      32 [.      78     109 ..      78     113 .. 0.94
   4 ?    6.4   0.0     0.012       9.1      58      86 ..     120     147 ..     116     150 .. 0.84

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.0024
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32
                 +++ vk l g+++ ++v++n t++++k  i+ 
   EFC39854.1  1 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 32
                 7899*************************997 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.012
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnkselsFv 86
                 L+f g++L+ d  +l++y i+++s+l+ v
   EFC39854.1 43 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 70
                 889999986.6789************976 PP

  == domain 3  score: 8.7 bits;  conditional E-value: 0.0024
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32 
                  +++ vk l g+++ ++v++n t++++k  i+ 
   EFC39854.1  78 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 109
                  7899*************************997 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.012
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L+f g++L+ d  +l++y i+++s+l+ v
   EFC39854.1 120 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 147
                  889999986.6789************976 PP

>> Sde2_N_Ubi  Silencing defective 2 N-terminal ubiquitin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.0   0.00016      0.12       2      88 ..       2      76 ..       1      77 [. 0.84
   2 !   12.4   0.0   0.00014       0.1       2      88 ..      79     153 ..      78     154 .] 0.84

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00016
  Sde2_N_Ubi  2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGG 88
                +++v+++ g+    t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGG
  EFC39854.1  2 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGG 76
                8999*99996....999*****************998877555.45555554.66..99999****999999....99********9 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 0.00014
  Sde2_N_Ubi   2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGG 88 
                 +++v+++ g+    t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGG
  EFC39854.1  79 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGG 153
                 8999*99996....999*****************998877555.45555554.66..99999****999999....9*********9 PP

>> DUF3861  Domain of Unknown Function with PDB structure (DUF3861)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.8   0.0    0.0048       3.6      19      59 ..       9      49 ..       5      55 .. 0.86
   2 !    7.9   0.0    0.0047       3.5      19      59 ..      86     126 ..      81     131 .. 0.86

  Alignments for each domain:
  == domain 1  score: 7.8 bits;  conditional E-value: 0.0048
     DUF3861 19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59
                + k++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC39854.1  9 TGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 49
                5579*************************999887776665 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0047
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC39854.1  86 TGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 126
                 5579*************************999887776665 PP

>> DUF2870  Protein of unknown function (DUF2870)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.6   0.0       4.8   3.6e+03      27      41 ..      25      39 ..       6      43 .. 0.52
   2 ?    6.8   0.0     0.012       8.8       3      26 ..      43      66 ..      41      79 .. 0.77
   3 ?    6.4   0.0     0.015        11       3      25 ..     120     142 ..     117     152 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.6 bits;  conditional E-value: 4.8
     DUF2870 27 kiivklqkkgsgaPa 41
                 +  k+q k+  +P 
  EFC39854.1 25 NVKSKIQDKEGIPPD 39
                334466666555554 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.012
     DUF2870  3 lWwagkelqrgkklsdyvGkNekt 26
                l +agk+l++g++lsdy  + e t
  EFC39854.1 43 LIFAGKQLEDGRTLSDYNIQKEST 66
                889*************97666655 PP

  == domain 3  score: 6.4 bits;  conditional E-value: 0.015
     DUF2870   3 lWwagkelqrgkklsdyvGkNek 25 
                 l +agk+l++g++lsdy  + e 
  EFC39854.1 120 LIFAGKQLEDGRTLSDYNIQKES 142
                 889*************9766555 PP

>> ACT_5  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.1   0.1    0.0066         5      34      53 ..      11      30 ..       1      31 [. 0.83
   2 !    7.3   0.1    0.0057       4.3      33      53 ..      87     107 ..      77     108 .. 0.82

  Alignments for each domain:
  == domain 1  score: 7.1 bits;  conditional E-value: 0.0066
       ACT_5 34 vrieltVesersvelLsnQl 53
                 +i+l+Ves++++e++ +++
  EFC39854.1 11 KTITLEVESNDTIENVKSKI 30
                58**************9998 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0057
       ACT_5  33 tvrieltVesersvelLsnQl 53 
                   +i+l+Ves++++e++ +++
  EFC39854.1  87 GKTITLEVESNDTIENVKSKI 107
                 468**************9998 PP

>> YcgR_2  Flagellar protein YcgR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.8   0.1      0.01       7.6       3      26 ..      10      33 ..       9      46 .. 0.88
   2 ?    6.8   0.1      0.01       7.6       3      26 ..      87     110 ..      86     123 .. 0.88

  Alignments for each domain:
  == domain 1  score: 6.8 bits;  conditional E-value: 0.01
                TSEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2  3 Gdkveieiesgdgekryksrvvdi 26
                G+ +++e+es+d  +++ks+++d 
  EFC39854.1 10 GKTITLEVESNDTIENVKSKIQDK 33
                899*******************85 PP

  == domain 2  score: 6.8 bits;  conditional E-value: 0.01
                 TSEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2   3 Gdkveieiesgdgekryksrvvdi 26 
                 G+ +++e+es+d  +++ks+++d 
  EFC39854.1  87 GKTITLEVESNDTIENVKSKIQDK 110
                 899*******************85 PP

>> ProRS-C_2  Prolyl-tRNA synthetase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.1    0.0083       6.2       6      26 ..      16      36 ..      12      37 .. 0.85
   2 ?    7.0   0.1    0.0083       6.2       6      26 ..      93     113 ..      89     114 .. 0.85

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0083
                S--....HHHHHHHCTTT-SE CS
   ProRS-C_2  6 aenvnlllenikeklsekkGv 26
                ++++n   en+k k+++k G+
  EFC39854.1 16 EVESNDTIENVKSKIQDKEGI 36
                57789*************997 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0083
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n   en+k k+++k G+
  EFC39854.1  93 EVESNDTIENVKSKIQDKEGI 113
                 57789*************997 PP

>> Tash_PEST  Tash protein PEST motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.2    0.0092       6.9       7      14 ..      12      19 ..      12      21 .. 0.90
   2 ?    7.0   0.2    0.0092       6.9       7      14 ..      89      96 ..      89      98 .. 0.90

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0092
   Tash_PEST  7 TIpVEigS 14
                TI++E++S
  EFC39854.1 12 TITLEVES 19
                9******* PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.0092
   Tash_PEST  7 TIpVEigS 14
                TI++E++S
  EFC39854.1 89 TITLEVES 96
                9******* PP

>> RBD  Raf-like Ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.0   0.0     0.017        12       9      42 ..      10      43 ..       9      62 .. 0.85
   2 ?    6.0   0.0     0.017        13       9      42 ..      87     120 ..      86     138 .. 0.85

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.017
         RBD  9 gqrtvvevkpgetvrdaLekalkkRglnpsacaV 42
                g++ + ev++++t++++ +k+  k g+ p++  +
  EFC39854.1 10 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRL 43
                578899*********************9987665 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.017
         RBD   9 gqrtvvevkpgetvrdaLekalkkRglnpsacaV 42 
                 g++ + ev++++t++++ +k+  k g+ p++  +
  EFC39854.1  87 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRL 120
                 578899*********************9987655 PP

>> UDP-g_GGTase  UDP-glucose:Glycoprotein Glucosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.2   0.1      0.25   1.8e+02      81     104 ..       2      25 ..       1      29 [. 0.86
   2 ?    9.9   0.1    0.0011       0.8      52     104 ..      49     102 ..      48     106 .. 0.83
   3 ?   -2.5   0.0       7.2   5.4e+03      53      68 ..     127     142 ..     126     146 .. 0.79

  Alignments for each domain:
  == domain 1  score: 2.2 bits;  conditional E-value: 0.25
                   EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  81 evvltsfegktlyprvkrkpgkek 104
                   ++++++++gkt++++v+ ++  e+
    EFC39854.1   2 QIFVKTLTGKTITLEVESNDTIEN 25 
                   6899************99987776 PP

  == domain 2  score: 9.9 bits;  conditional E-value: 0.0011
                   EE-TTHHHHHEEEEE--SS-S--TT--.--EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  52 elregrssdiyeiesvgaeglsspkde.gkevvltsfegktlyprvkrkpgkek 104
                   +l++gr+ + y+i++ ++ +l  + +  g ++++++++gkt++++v+ ++  e+
    EFC39854.1  49 QLEDGRTLSDYNIQKESTLHLVLRLRGgGMQIFVKTLTGKTITLEVESNDTIEN 102
                   5889**********999998644443448*****************99987776 PP

  == domain 3  score: -2.5 bits;  conditional E-value: 7.2
                   E-TTHHHHHEEEEE-- CS
  UDP-g_GGTase  53 lregrssdiyeiesvg 68 
                   l++gr+ + y+i++ +
    EFC39854.1 127 LEDGRTLSDYNIQKES 142
                   7889999999998765 PP

>> UN_NPL4  Nuclear pore localisation protein NPL4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.2   0.0      0.02        15      16      46 ..      13      43 ..       3      71 .. 0.83
   2 ?    6.3   0.0     0.018        13      16      46 ..      90     120 ..      76     147 .. 0.82

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.02
                EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4 16 kRieisekstlktllekvaeelkfsengfsl 46
                + +e++++ t+++ ++k++++ +++  ++ l
  EFC39854.1 13 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 43
                568999*****************99988776 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.018
                 EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4  16 kRieisekstlktllekvaeelkfsengfsl 46 
                 + +e++++ t+++ ++k++++ +++  ++ l
  EFC39854.1  90 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 120
                 568999*****************99988776 PP

>> DUF1866  Domain of unknown function (DUF1866)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5   0.0     0.018        14      92     118 ..       6      32 ..       1      50 [. 0.86
   2 ?    5.6   0.0     0.017        13      92     118 ..      83     109 ..      77     127 .. 0.86

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.018
                 SEETTEEEEEEEXXXXXXXXXXXXXXX CS
     DUF1866  92 vkvlgralkiklkskdWlksleeeill 118
                 ++++g+++++++ s+d ++++++ i  
  EFC39854.1   6 KTLTGKTITLEVESNDTIENVKSKIQD 32 
                 6789*******************9943 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.017
                 SEETTEEEEEEEXXXXXXXXXXXXXXX CS
     DUF1866  92 vkvlgralkiklkskdWlksleeeill 118
                 ++++g+++++++ s+d ++++++ i  
  EFC39854.1  83 KTLTGKTITLEVESNDTIENVKSKIQD 109
                 6789*******************9943 PP

>> NETI  NETI protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.1   0.0     0.026        19       2      19 ..      15      32 ..      14      40 .. 0.81
   2 ?   -0.7   0.0       1.7   1.2e+03      39      56 .]      31      48 ..      27      48 .. 0.74
   3 ?    5.1   0.0     0.026        19       2      19 ..      92     109 ..      91     117 .. 0.81
   4 ?   -0.7   0.0       1.7   1.2e+03      39      56 .]     108     125 ..     104     125 .. 0.74

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.026
        NETI  2 feVeeneTIedcLeRmkk 19
                 eVe n+TIe++ ++++ 
  EFC39854.1 15 LEVESNDTIENVKSKIQD 32
                59**********999973 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 1.7
        NETI 39 ngkkeiepvrqkIvFegk 56
                + k+ i p +q+ +F gk
  EFC39854.1 31 QDKEGIPPDQQRLIFAGK 48
                556667788999999986 PP

  == domain 3  score: 5.1 bits;  conditional E-value: 0.026
        NETI   2 feVeeneTIedcLeRmkk 19 
                  eVe n+TIe++ ++++ 
  EFC39854.1  92 LEVESNDTIENVKSKIQD 109
                 59**********999973 PP

  == domain 4  score: -0.7 bits;  conditional E-value: 1.7
        NETI  39 ngkkeiepvrqkIvFegk 56 
                 + k+ i p +q+ +F gk
  EFC39854.1 108 QDKEGIPPDQQRLIFAGK 125
                 556667788999999986 PP

>> FERM_f0  N-terminal or F0 domain of Talin-head FERM
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.0   0.1     0.041        31      58      78 ..      47      67 ..       4      69 .. 0.69
   2 ?    5.0   0.1     0.041        31      58      78 ..     124     144 ..      81     146 .. 0.69

  Alignments for each domain:
  == domain 1  score: 5.0 bits;  conditional E-value: 0.041
     FERM_f0 58 gvWlenertLeyYllrngdel 78
                g+ le +rtL+ Y ++++++l
  EFC39854.1 47 GKQLEDGRTLSDYNIQKESTL 67
                466999999999999999887 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.041
     FERM_f0  58 gvWlenertLeyYllrngdel 78 
                 g+ le +rtL+ Y ++++++l
  EFC39854.1 124 GKQLEDGRTLSDYNIQKESTL 144
                 466999999999999999887 PP

>> Plexin_cytopl  Plexin cytoplasmic RasGAP domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.2     0.015        11     200     223 ..       9      32 ..       1      36 [. 0.83
   2 ?    5.4   0.4    0.0079       5.9     200     223 ..      86     109 ..      54     113 .. 0.74
   3 ?   -1.3   0.0      0.89   6.7e+02     271     289 ..     131     149 ..     115     151 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.015
                    ---EEEEEEETT-BHHHHHHHHHH CS
  Plexin_cytopl 200 esekvevkvldcDtitQvkeKild 223
                      ++++++v + Dti+ vk+Ki d
     EFC39854.1   9 TGKTITLEVESNDTIENVKSKIQD 32 
                    5678999**************976 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0079
                    ---EEEEEEETT-BHHHHHHHHHH CS
  Plexin_cytopl 200 esekvevkvldcDtitQvkeKild 223
                      ++++++v + Dti+ vk+Ki d
     EFC39854.1  86 TGKTITLEVESNDTIENVKSKIQD 109
                    678999***************976 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.89
                    -BTTTTT--TTEEEEEE-T CS
  Plexin_cytopl 271 nTlahYkvsdgavlalvkk 289
                     Tl++Y+++ +++l+lv +
     EFC39854.1 131 RTLSDYNIQKESTLHLVLR 149
                    6999*****9999999865 PP

>> PI3K_p85B  PI3-kinase family, p85-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.1     0.022        17       1      18 [.      13      30 ..      13      34 .. 0.92
   2 ?    5.3   0.1     0.022        17       1      18 [.      90     107 ..      90     111 .. 0.92

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.022
   PI3K_p85B  1 itlrvsreatLseiKeeL 18
                itl+v+++ t++++K+++
  EFC39854.1 13 ITLEVESNDTIENVKSKI 30
                89*************986 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.022
   PI3K_p85B   1 itlrvsreatLseiKeeL 18 
                 itl+v+++ t++++K+++
  EFC39854.1  90 ITLEVESNDTIENVKSKI 107
                 89*************986 PP

>> HAMP_N3  HAMP N-terminal domain 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.1     0.032        24      32      43 .]      20      31 ..      20      31 .. 0.93
   2 ?    4.6   0.1     0.032        24      32      43 .]      97     108 ..      97     108 .. 0.93

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.032
                HHHHHHHHHHH- CS
     HAMP_N3 32 netieqvRgnLk 43
                n+tie+v+++++
  EFC39854.1 20 NDTIENVKSKIQ 31
                9********986 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.032
                 HHHHHHHHHHH- CS
     HAMP_N3  32 netieqvRgnLk 43 
                 n+tie+v+++++
  EFC39854.1  97 NDTIENVKSKIQ 108
                 9********986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       420  (0.0234257); expected 358.6 (0.02)
Passed bias filter:                      325  (0.0181271); expected 358.6 (0.02)
Passed Vit filter:                        46  (0.00256568); expected 17.9 (0.001)
Passed Fwd filter:                        24  (0.00133861); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              24  [number of targets reported over threshold]
# CPU time: 0.44u 0.26s 00:00:00.70 Elapsed: 00:00:00.42
# Mc/sec: 1111.80
//
Query:       EFC39855.1  [L=602]
Description: CAP-Gly domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    3.1e-15   56.1   1.1    1.6e-08   34.3   0.1    2.5  2  LRR_9        Leucine-rich repeat
    5.3e-14   52.0   0.1    1.2e-13   50.9   0.1    1.5  1  CAP_GLY      CAP-Gly domain
    2.5e-13   49.9  15.3     0.0015   18.8   0.4    5.6  5  LRR_4        Leucine Rich repeats (2 copies)
    3.5e-12   45.9  17.1    0.00013   21.6   0.1    4.7  5  LRR_8        Leucine rich repeat
    0.00016   21.5   8.1        3.6    7.9   0.2    6.5  7  LRR_6        Leucine Rich repeat
    0.00092   19.6   0.0     0.0027   18.1   0.0    1.8  1  Ubiquitin_2  Ubiquitin-like domain
  ------ inclusion threshold ------
        6.1    7.8   5.3         99    4.1   0.1    4.5  5  LRR_1        Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.0   0.1   1.4e-07   0.00037      22     124 ..     179     287 ..     158     293 .. 0.75
   2 !   34.3   0.1   6.2e-12   1.6e-08      40     168 ..     300     435 ..     291     440 .. 0.89

  Alignments for each domain:
  == domain 1  score: 20.0 bits;  conditional E-value: 1.4e-07
       LRR_9  22 reldlrgykipvien.lGatldqfdtidlsdndirkldgf....PllkrlktlllnnnrivriaegleevlPnleelvltnnel..qela.dldPlasl 112
                  +l+l+  k++ ie  +Ga  +    idls n i    ++      + +l  l++++nr  ++    +++ Pnl+ lv+++ ++  + ++ ++ Pl  +
  EFC39855.1 179 TDLGLQDCKVSSIEKgIGANFENVRGIDLSANLIETWSQVetllEEFPKLTNLIISSNRFSQVVVSKGRTYPNLKMLVVNDVSFgwKTFVeEILPL--F 275
                 579999*******955****************99865554100134578999***************************99875113333133333..4 PP

       LRR_9 113 kklellsllknp 124
                 +++e + + +n 
  EFC39855.1 276 PNIEEVHFRDNN 287
                 555555555555 PP

  == domain 2  score: 34.3 bits;  conditional E-value: 6.2e-12
       LRR_9  40 tldqfdtidlsdndirkld....gfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtnk...key 131
                 tl    +++ls n+i + d    +f  +  l  llln n +  ++   e    +l+++ +++n+++e   l+ l +++ le l l +np+ +k   ++ 
  EFC39855.1 300 TLSSIQSLNLSGNKIANWDavwnSFSNFATLTRLLLNYNALSSVKFMKEGGFSSLKSISVASNKIEEYDSLNELNNMPLLEELRLESNPIQEKygvNNV 398
                 566677899999999987733335899999****************99*******************************************98555689 PP

       LRR_9 132 rlyviyklkqlrlldfrkvklkereeaeklfkskkgk 168
                 r+y + +++ l  ++   v++kere+aek++  + g+
  EFC39855.1 399 RQYAVARIRGLISFNGSEVRKKEREDAEKYYLKQCGR 435
                 ***********99999*************99777665 PP

>> CAP_GLY  CAP-Gly domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.9   0.1   4.5e-17   1.2e-13       9      63 ..      59     117 ..      52     119 .. 0.82

  Alignments for each domain:
  == domain 1  score: 50.9 bits;  conditional E-value: 4.5e-17
     CAP_GLY   9 egrrGvvryvGpvpfakg.ewvGveld.epnGkndGsvkgkrYFeck..pnrGvFvrpe 63 
                 +  rG vr++G++++a++  +vGve+d e++Gk+dG+ +g+rYF ++  +++++F++ e
  EFC39855.1  59 DVSRGFVRFIGKIDQASSqLFVGVEWDyEERGKHDGELNGVRYFVTStgKKSASFIKLE 117
                 6689*********966662688*****5569*************75533789***9976 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.7   0.0   0.00047       1.2       2      38 ..     177     214 ..     176     223 .. 0.86
   2 !    5.7   0.1     0.008        21       1      33 [.     226     258 ..     226     264 .. 0.77
   3 !   18.8   0.4     6e-07    0.0015       1      37 [.     276     315 ..     276     323 .. 0.84
   4 !   15.4   0.2   7.5e-06     0.019       3      43 ..     330     371 ..     328     372 .. 0.86
   5 !   16.4   1.9   3.5e-06     0.009       2      36 ..     353     389 ..     352     397 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00047
                 S--EEE--SS---E-S-.HH.H-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdipl.le.klpnLkeLdLsgNnlitd 38 
                 +L+ L L+++++++i+  ++ ++ n + +dLs N li++
  EFC39855.1 177 KLTDLGLQDCKVSSIEKgIGaNFENVRGIDLSAN-LIET 214
                 899**************95547*********999.8865 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.008
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgN 33 
                 p+L++L +s+N+ + +     +  pnLk L +  N
  EFC39855.1 226 PKLTNLIISSNRFSQVVVskGRTYPNLKMLVV--N 258
                 79**********99555535335999999977..3 PP

  == domain 3  score: 18.8 bits;  conditional E-value: 6e-07
                 SS--EEE--SS---E-S-....HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl....leklpnLkeLdLsgNnlit 37 
                 pn e++++++N++td +l    l  l + ++L+LsgN +i 
  EFC39855.1 276 PNIEEVHFRDNNVTDEDLkssqLPTLSSIQSLNLSGN-KIA 315
                 799************9998766336999*********.654 PP

  == domain 4  score: 15.4 bits;  conditional E-value: 7.5e-06
                 --EEE--SS---E-S-..HHH-TT--EEE-.-S-----GGGGX CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeLdLsgNnlitdldeLk 43 
                 L+ L L+ N l+++ +   +++ +Lk++++ +N +i+  d+L+
  EFC39855.1 330 LTRLLLNYNALSSVKFmkEGGFSSLKSISVASN-KIEEYDSLN 371
                 99**************96557*********777.888877775 PP

  == domain 5  score: 16.4 bits;  conditional E-value: 3.5e-06
                 S--EEE--SS---E-S-HH...H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqltdiplle...klpnLkeLdLsgNnli 36 
                 +L++++ ++N++ + ++l+   ++p L+eL L +N +i
  EFC39855.1 353 SLKSISVASNKIEEYDSLNelnNMPLLEELRLESN-PI 389
                 799**************666648*********777.66 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.1   5.2e-08   0.00013       2      61 .]     177     238 ..     176     238 .. 0.92
   2 !    7.5   0.1    0.0014       3.5       1      31 [.     226     256 ..     226     259 .. 0.92
   3 !   14.3   4.5   9.8e-06     0.025       3      61 .]     278     340 ..     276     340 .. 0.80
   4 !   20.7   3.5     1e-07   0.00026       2      61 .]     329     389 ..     328     389 .. 0.96
   5 ?   -2.8   0.0       2.2   5.5e+03       3      17 ..     510     524 ..     509     526 .. 0.82

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 5.2e-08
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGG..GGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttls..pgafsgLpsLrsLdLsgNrL 61 
                 +Lt L L++ + +s++++   +++n++ +dLs Nl++t s  +  ++ +p+L+ L +s+Nr+
  EFC39855.1 177 KLTDLGLQDCKVSSIEKGIGANFENVRGIDLSANLIETWSqvETLLEEFPKLTNLIISSNRF 238
                 79************************************77224679**************85 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0014
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLd 31 
                 p+Lt+L++s+Nr++ +  +  ++ +nLk+L 
  EFC39855.1 226 PKLTNLIISSNRFSQVVVSKGRTYPNLKMLV 256
                 79****************999999***9996 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 9.8e-06
                 -SEEE-TTS--S..EE-TTSSTT-TT--EEE--SS---G..GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   3 LtsLdLsnNrlt..slddeaFkglsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsgNrL 61 
                  ++++ ++N+ t  +l+ ++  +ls+ ++L+Ls N++      +++fs+++ L+ L L++N L
  EFC39855.1 278 IEEVHFRDNNVTdeDLKSSQLPTLSSIQSLNLSGNKIANwdAVWNSFSNFATLTRLLLNYNAL 340
                 55666666665422688899999**************995545899***************87 PP

  == domain 4  score: 20.7 bits;  conditional E-value: 1e-07
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---G.GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNlltt.lspgafsgLpsLrsLdLsgNrL 61 
                 +Lt+L L+ N l+s++     g+s+Lk+++  +N+++   s + + ++p L++L L++N++
  EFC39855.1 329 TLTRLLLNYNALSSVKFMKEGGFSSLKSISVASNKIEEyDSLNELNNMPLLEELRLESNPI 389
                 69************************************7789*****************97 PP

  == domain 5  score: -2.8 bits;  conditional E-value: 2.2
                 -SEEE-TTS--SEE- CS
       LRR_8   3 LtsLdLsnNrltsld 17 
                  ++L L + rl +l+
  EFC39855.1 510 IQKLKLMCQRLFKLE 524
                 589999999998887 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.44   1.1e+03       4      16 ..     177     189 ..     176     190 .. 0.87
   2 ?    1.0   0.0      0.23   5.9e+02       4      15 ..     227     238 ..     226     240 .. 0.87
   3 !    7.0   0.0    0.0028       7.1       4      21 ..     277     294 ..     276     295 .. 0.88
   4 !    7.9   0.2    0.0014       3.6       3      16 ..     302     315 ..     300     316 .. 0.87
   5 ?   -1.7   0.1       1.6   4.2e+03       4      16 ..     329     341 ..     328     343 .. 0.86
   6 ?    1.6   0.0      0.14   3.7e+02       3      15 ..     352     364 ..     352     365 .. 0.91
   7 ?    0.6   0.0      0.31   7.9e+02       4      16 ..     378     390 ..     375     391 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.44
       LRR_6   4 hLteLdLsgNdIg 16 
                 +Lt L L++++++
  EFC39855.1 177 KLTDLGLQDCKVS 189
                 699*******975 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.23
       LRR_6   4 hLteLdLsgNdI 15 
                 +Lt L +s+N +
  EFC39855.1 227 KLTNLIISSNRF 238
                 8*********86 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0028
       LRR_6   4 hLteLdLsgNdIgDeGae 21 
                 +++e++ ++N+++De ++
  EFC39855.1 277 NIEEVHFRDNNVTDEDLK 294
                 7899***********987 PP

  == domain 4  score: 7.9 bits;  conditional E-value: 0.0014
       LRR_6   3 thLteLdLsgNdIg 16 
                 +++++L+LsgN+I 
  EFC39855.1 302 SSIQSLNLSGNKIA 315
                 7899********95 PP

  == domain 5  score: -1.7 bits;  conditional E-value: 1.6
       LRR_6   4 hLteLdLsgNdIg 16 
                 +Lt L L++N ++
  EFC39855.1 329 TLTRLLLNYNALS 341
                 89***9****886 PP

  == domain 6  score: 1.6 bits;  conditional E-value: 0.14
       LRR_6   3 thLteLdLsgNdI 15 
                 ++L++ ++++N+I
  EFC39855.1 352 SSLKSISVASNKI 364
                 68**********9 PP

  == domain 7  score: 0.6 bits;  conditional E-value: 0.31
       LRR_6   4 hLteLdLsgNdIg 16 
                  L+eL L +N I+
  EFC39855.1 378 LLEELRLESNPIQ 390
                 599*******995 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.1   0.0   1.1e-06    0.0027       7      80 ..     492     563 ..     486     569 .. 0.88

  Alignments for each domain:
  == domain 1  score: 18.1 bits;  conditional E-value: 1.1e-06
                  EETTSS.SEEEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2   7 tssltkavsserrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                  +ss     + e++++ + ti++lK   ++++  +++++rL ++ d + +  + l dd +  ++Y vkdg +i  
   EFC39855.1 492 VSSSQ-GHVVEKKIPYGFTIQKLKLMCQRLFKLEASKQRLFYI-DVGHSLPEPLGDDFKDIDFYAVKDGGTIIM 563
                  44444.4789*********************************.9************************98865 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.6     4e+03       1      14 [.     227     240 ..     227     245 .. 0.84
   2 ?    4.1   0.1     0.039        99       2      22 ..     304     326 ..     303     327 .. 0.72
   3 ?   -2.9   0.1         7   1.8e+04       2      12 ..     330     340 ..     329     345 .. 0.80
   4 ?   -2.7   0.0       6.5   1.7e+04       1      12 [.     353     364 ..     353     373 .. 0.81
   5 ?    2.3   0.0      0.16     4e+02       2      12 ..     379     389 ..     378     409 .. 0.90

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.6
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L+ L +s+n++++
  EFC39855.1 227 KLTNLIISSNRFSQ 240
                 789999****9876 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.039
       LRR_1   2 LrhLdLsnnpl..lglppnsfqn 22 
                  ++L+Ls+n +   +   nsf+n
  EFC39855.1 304 IQSLNLSGNKIanWDAVWNSFSN 326
                 689******98665556666665 PP

  == domain 3  score: -2.9 bits;  conditional E-value: 7
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L L++n l
  EFC39855.1 330 LTRLLLNYNAL 340
                 89999999976 PP

  == domain 4  score: -2.7 bits;  conditional E-value: 6.5
       LRR_1   1 nLrhLdLsnnpl 12 
                 +L+++ + +n +
  EFC39855.1 353 SLKSISVASNKI 364
                 699999999987 PP

  == domain 5  score: 2.3 bits;  conditional E-value: 0.16
       LRR_1   2 LrhLdLsnnpl 12 
                 L++L L++np+
  EFC39855.1 379 LEELRLESNPI 389
                 99********8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (602 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1026  (0.0572257); expected 358.6 (0.02)
Passed bias filter:                      439  (0.0244855); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.26s 00:00:00.91 Elapsed: 00:00:00.45
# Mc/sec: 4060.91
//
Query:       EFC39856.1  [L=1168]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.4e-07   30.5   0.1    6.7e-07   29.0   0.1    1.7  1  hSac2     Inositol phosphatase
    0.00037   20.4   0.2        5.8    7.1   0.0    4.9  4  Arm       Armadillo/beta-catenin-like repeat
  ------ inclusion threshold ------
       0.17   12.6   1.4        9.4    7.0   0.0    3.5  3  DUF4259   Domain of unknown function (DUF4259)


Domain annotation for each model (and alignments):
>> hSac2  Inositol phosphatase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.0   0.1   1.1e-10   6.7e-07      18      73 ..     884     934 ..     875     965 .. 0.84

  Alignments for each domain:
  == domain 1  score: 29.0 bits;  conditional E-value: 1.1e-10
       hSac2  18 kklvlsdedeeflggWlLlspdesntksekeeervlLLTdkalyickydfnlekvs 73 
                 +k v+sd +e f++gW +l++++        +er+lLLT++++y + +d +++k+ 
  EFC39856.1 884 SKSVISD-EELFIKGWRILKMNKDGM----LQERILLLTNTSYYTVCFDPKSKKID 934
                 4667799.9***************88....**********************9984 PP

>> Arm  Armadillo/beta-catenin-like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.1      0.84     5e+03      14      41 .]      47      75 ..      45      75 .. 0.81
   2 ?    2.9   0.0      0.02   1.2e+02      12      39 ..      88     116 ..      80     123 .. 0.82
   3 ?    3.9   0.0      0.01        61      10      27 ..     266     283 ..     262     286 .. 0.86
   4 !    7.1   0.0   0.00097       5.8       2      24 ..     510     534 ..     509     540 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.84
                HHHHHHHTT.TSSHHHHHHHHHHHHHHTT CS
         Arm 14 vppLvrLLs.sedeevqeeAawALsNLaa 41
                ++  ++ L  +e+ ++   +++A+++La+
  EFC39856.1 47 LQLVIQILGeTENRMIINSILSAIQHLAS 75
                66677888888999999999999999986 PP

  == domain 2  score: 2.9 bits;  conditional E-value: 0.02
                 THHHHHHHHTT.TSSHHHHHHHHHHHHHH CS
         Arm  12 GavppLvrLLs.sedeevqeeAawALsNL 39 
                 ++++ Lv  +s    +++q  A+ A++ L
  EFC39856.1  88 NCIQLLVPHMSqFNFPNIQSGALDAMAEL 116
                 78899999999999999999998888766 PP

  == domain 3  score: 3.9 bits;  conditional E-value: 0.01
                 HTTHHHHHHHHTTTSSHH CS
         Arm  10 eaGavppLvrLLssedee 27 
                 e+G+v+pL++ +++++ e
  EFC39856.1 266 ESGIVEPLIEIMYHTSLE 283
                 89***********98876 PP

  == domain 4  score: 7.1 bits;  conditional E-value: 0.00097
                 HHHHHHHHHTTHHHHHHHHTT..TS CS
         Arm   2 senkdavieaGavppLvrLLs..se 24 
                 +++++ + e+G++++L+++++  +e
  EFC39856.1 510 DDCIQKLGEMGVIKRLLKMIDerNE 534
                 799*****************94444 PP

>> DUF4259  Domain of unknown function (DUF4259)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   0.0    0.0016       9.4      12     116 ..     108     210 ..     106     216 .. 0.90
   2 ?    0.6   0.0      0.15   9.1e+02      89     121 ..     604     639 ..     529     643 .. 0.75
   3 ?    0.9   0.0      0.12     7e+02      10     100 ..     710     798 ..     709     847 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.0016
     DUF4259  12 tAaDflaeledakpedrleliiealeevadaeedeyleadegaealaaaelvaallggeteieeaesekidlpedieefveklqksddadlrelarral 110
                 +A+D++ael +  ++++ e ++++++e++  +  + ++ + +a+   a +++++l++++  + +++++k  ++e +e  +  lq ++ + + ++a++++
  EFC39856.1 108 GALDAMAELLKGSKKNQ-ENLVQYVSEFF-NPLMGIIQRENDATTKKAFAVLDSLFENPICVHAVFGDKDRYDEYLEPLIICLQIENNRLVLQWALQTI 204
                 69**********87766.99999999977.57789**********************************8788999999999999999*********** PP

     DUF4259 111 drvlae 116
                 ++ +++
  EFC39856.1 205 EKACRQ 210
                 998876 PP

  == domain 2  score: 0.6 bits;  conditional E-value: 0.15
     DUF4259  89 efveklqksdd..adlrelarraldrvlaek.sElk 121
                 + +  ++k +   +++r++a++++++  +++ s+l+
  EFC39856.1 604 KKIRDISKREVvfEEVRKMAKQVIKVFKENNkSSLR 639
                 333344433337799***********9999988876 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.12
     DUF4259  10 nDtAaDflaeledakpedrleliiealeevadaeedeyleadegaealaaaelvaallggeteieeaesek.i.dlpedieefveklqksdd...a 100
                 +D+A+ +l++l+ +   ++  + iea+ e+a+  ++    +  +   l++ e++  + ++e+++++ e+e+    ++ +i + + k++ s+d    
  EFC39856.1 710 SDEAITLLGRLDLY---EEFYMAIEAFIEAAE-INA---NIFNANVPLVVLEVLPPVKKEENSKKKDEEEEeAvPCELEIGDLIMKYKLSPDgilW 798
                 68888999999998...456788888888443.333...345666669999999999999999888777775579999999999999888875552 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1168 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1369  (0.0763567); expected 358.6 (0.02)
Passed bias filter:                      471  (0.0262703); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.97u 0.40s 00:00:01.37 Elapsed: 00:00:00.61
# Mc/sec: 5775.09
//
Query:       EFC39857.1  [L=1190]
Description: hypothetical protein NAEGRDRAFT_59175 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
  ------ inclusion threshold ------
       0.17   12.4  15.6         28    5.3   0.0    5.7  5  LRR_4         Leucine Rich repeats (2 copies)


Domain annotation for each model (and alignments):
>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.3   0.0    0.0015        28      12      30 ..     285     303 ..     282     308 .. 0.87
   2 ?    3.5   3.4    0.0059   1.1e+02      19      31 ..     350     363 ..     323     373 .. 0.64
   3 ?    5.0   0.6    0.0019        34       1      29 [.     381     409 ..     381     429 .. 0.76
   4 ?   -0.3   0.1     0.091   1.6e+03       3      28 ..     405     430 ..     403     447 .. 0.66
   5 ?    0.2   0.1     0.063   1.1e+03      13      28 ..     437     454 ..     425     459 .. 0.75

  Alignments for each domain:
  == domain 1  score: 5.3 bits;  conditional E-value: 0.0015
                 ---E-S-HHH-TT--EEE- CS
       LRR_4  12 qltdiplleklpnLkeLdL 30 
                 +l+ i+ le l+nLk+L L
  EFC39857.1 285 HLKQIDHLEELKNLKHLCL 303
                 58899**99********76 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.0059
                 HHH.-TT--EEE-. CS
       LRR_4  19 lek.lpnLkeLdLs 31 
                 +++ lpnL++L+L 
  EFC39857.1 350 INNsLPNLTYLNLK 363
                 3455********94 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.0019
                 SS--EEE--.S..S---E-S-HHH-TT--EEE CS
       LRR_4   1 pnLevLdLs.n..NqltdiplleklpnLkeLd 29 
                 ++L++L L+ +  N++ ++++   l++L++L 
  EFC39857.1 381 KKLKTLILGsHeqNCVAKLGN---LKQLEYLE 409
                 68*******6367*****888...*****997 PP

  == domain 4  score: -0.3 bits;  conditional E-value: 0.091
                 --EEE--SS---E-S-..HHH-TT--EE CS
       LRR_4   3 LevLdLsnNqltdipl..leklpnLkeL 28 
                 Le+L  s+  l+  +   +++l nLk+L
  EFC39857.1 405 LEYLEASD--LSAKDVntISQLVNLKSL 430
                 66666666..442222235568888888 PP

  == domain 5  score: 0.2 bits;  conditional E-value: 0.063
                 --E-S-..HHH-TT--EE CS
       LRR_4  13 ltdipl..leklpnLkeL 28 
                 +td ++  lekl+nL+++
  EFC39857.1 437 ITDEEGkdLEKLKNLEQF 454
                 788777788999999986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1190 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      5247  (0.292654); expected 358.6 (0.02)
Passed bias filter:                     1058  (0.0590105); expected 358.6 (0.02)
Passed Vit filter:                       728  (0.0406046); expected 17.9 (0.001)
Passed Fwd filter:                       254  (0.014167); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 4.53u 0.41s 00:00:04.94 Elapsed: 00:00:00.95
# Mc/sec: 3799.40
//
Query:       EFC39858.1  [L=218]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       444  (0.0247643); expected 358.6 (0.02)
Passed bias filter:                      283  (0.0157845); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.58u 0.33s 00:00:00.90 Elapsed: 00:00:00.56
# Mc/sec: 1163.14
//
Query:       EFC39859.1  [L=1084]
Description: S_TKc domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    1.8e-36  125.9   1.5    4.1e-36  124.7   1.5    1.6  1  Pkinase      Protein kinase domain
      3e-25   87.7   7.1    9.8e-12   44.4   0.0    6.4  7  DUF4116      Domain of unknown function (DUF4116)
    6.9e-22   77.4  22.5    4.6e-07   30.3   0.3    7.5  9  Sel1         Sel1 repeat
    1.4e-17   63.9   4.7    2.3e-16   59.9   1.3    2.9  2  Pkinase_Tyr  Protein tyrosine kinase
    5.9e-10   39.1   5.9    1.3e-09   38.0   4.5    2.3  2  PX           PX domain
    0.00013   21.9   3.9       0.16   12.3   0.4    4.7  5  TPR_8        Tetratricopeptide repeat
     0.0014   18.4   5.6       0.15   11.9   0.3    4.0  3  TPR_1        Tetratricopeptide repeat
     0.0043   17.3   1.0         10    6.5   0.0    3.8  4  TPR_12       Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.025   14.7   8.1        2.2    8.6   0.2    4.9  5  TPR_2        Tetratricopeptide repeat
      0.043   13.9   1.9       0.16   12.1   0.1    3.0  3  TPR_7        Tetratricopeptide repeat


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  124.7   1.5   2.3e-39   4.1e-36       1     259 [.     172     444 ..     172     448 .. 0.88

  Alignments for each domain:
  == domain 1  score: 124.7 bits;  conditional E-value: 2.3e-39
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHS...CTTB--EEEEEEESSEEEEEEE--TTEBHHHHHHHHSS-- CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklk...hpnivrlyevfeekdelylvleyveggeladllerkgsls 96 
                 y+  + +G+G++GkVy  v +++g ++A+K+i     + +    v + +k++ +++    ++i+r++++f+  +++y+v+ey ++g+l+++ + ++++s
  EFC39859.1 172 YKLSKFIGNGTYGKVYHSV-DDSGYEYAIKEIPALYVDTMF---VENNVKLISECNetfLRYILRILDTFQIANNYYVVTEYFNKGSLNNIRN-DVKMS 265
                 677899*************.6*************9999877...56677777777766699****************************9986.799** PP

                 HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEE.TTTE...EEE-SGTTSEESSSSCS.......................BCTTTSCGGGS-HHH CS
     Pkinase  97 eeeakkiakqilegleylHskgiiHrDlKpeNiLid.ekge...lKitDFGlakelesssk.......................ltsfvgtseYlAPEv 168
                  +++ +i+ q++++l++l sk+++H D+K  Ni+++  +g+   l ++D+Gl+++++ s +                        +  vgt+ Y APE+
  EFC39859.1 266 VSTILQIIIQMVTSLRFLNSKKMVHLDIKEGNIFVQfFNGHrisLILGDLGLSRKINPSIQlntinnninnieivkeslfeslsSSASVGTPLYQAPEM 364
                 ************************************9888899999*************99*********************999999*********** PP

                 H.TTSCB.SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHHCTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHH CS
     Pkinase 169 l.keney.skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilkilgetkeklpeaseiseeakdllkkllkkdpkkRltaeell 259
                 l +en++  +k+D++slG++++  l+gk     +++k   e + +++ ++++ l     + pe++     + +ll+k+l+ d ++R   + +l
  EFC39859.1 365 LqQENPFiHEKSDIYSLGCTILYYLFGKIKVL-NQEK---ELDWEKINSLFQKL-----EEPEWK----YIYELLQKMLTIDVNERADTKTIL 444
                 *8788889*******************99988.2333...33444433344444.....446665....5689*************9988887 PP

>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.3   0.1       4.5     8e+03       4      19 ..     118     133 ..     117     134 .. 0.74
   2 ?   -2.2   0.0       1.9   3.5e+03      25      33 ..     335     343 ..     326     366 .. 0.61
   3 ?    3.1   0.4     0.044        79      12      38 ..     501     527 ..     495     539 .. 0.86
   4 !   21.4   0.0   8.2e-08   0.00015       4      38 ..     570     604 ..     567     605 .. 0.96
   5 !   44.4   0.0   5.5e-15   9.8e-12       1      45 [.     592     636 ..     592     639 .. 0.95
   6 !   34.8   0.0   5.3e-12   9.6e-09       1      45 [.     641     685 ..     641     691 .. 0.96
   7 ?   -2.8   0.0         3   5.5e+03       1      11 [.     711     721 ..     705     725 .. 0.68

  Alignments for each domain:
  == domain 1  score: -3.3 bits;  conditional E-value: 4.5
     DUF4116   4 ivleavkkngsalkyl 19 
                 ++l+ + + ++  +y+
  EFC39859.1 118 FILKFINIPNELMQYV 133
                 7788888877777775 PP

  == domain 2  score: -2.2 bits;  conditional E-value: 1.9
     DUF4116  25 nDkeivlkA 33 
                 n++eiv++ 
  EFC39859.1 335 NNIEIVKES 343
                 566666664 PP

  == domain 3  score: 3.1 bits;  conditional E-value: 0.044
     DUF4116  12 ngsalkylseeLknDkeivlkAvkqng 38 
                 ng+ l+ l+e +kn+ +    A +qn+
  EFC39859.1 501 NGNQLEDLPEHFKNNSNYFNIAAQQNS 527
                 8999***********987777777765 PP

  == domain 4  score: 21.4 bits;  conditional E-value: 8.2e-08
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqng 38 
                 ++l  v+k+g+ l+++ + Lk ++ iv+ Avkqn+
  EFC39859.1 570 FALSSVSKDGKTLRFVGHLLKMNRTIVMTAVKQNP 604
                 78999*****************************8 PP

  == domain 5  score: 44.4 bits;  conditional E-value: 5.5e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 +r iv+ avk+n++a++y++++L++Dkei+++A+  ng  l+y+ 
  EFC39859.1 592 NRTIVMTAVKQNPLAIQYAPSSLRKDKEIAKEALVYNGRTLEYLE 636
                 688****************************************86 PP

  == domain 6  score: 34.8 bits;  conditional E-value: 5.3e-12
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 D+Eivl av+ +g a+k++s++L+++ +i+ +Avk +  a++ya+
  EFC39859.1 641 DEEIVLAAVSVHGIAIKFASPRLRSHENIIRRAVKVDERAIEYAD 685
                 9******************************************97 PP

  == domain 7  score: -2.8 bits;  conditional E-value: 3
     DUF4116   1 DrEivleavkk 11 
                 D+ +v+ +vk+
  EFC39859.1 711 DEKLVMDYVKQ 721
                 56667777766 PP

>> Sel1  Sel1 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.6   2.8e+03       5      19 ..     379     393 ..     378     400 .. 0.76
   2 ?   -3.0   0.1       7.5   1.3e+04      28      35 ..     538     545 ..     538     546 .. 0.89
   3 ?   -2.3   0.0       4.7   8.3e+03      24      36 ..     796     808 ..     795     810 .. 0.82
   4 ?   -1.0   0.1       1.8   3.3e+03      28      38 .]     828     838 ..     828     838 .. 0.92
   5 ?    5.9   0.1     0.012        22      25      37 ..     861     873 ..     843     874 .. 0.71
   6 !   30.3   0.3   2.6e-10   4.6e-07       1      36 [.     875     908 ..     875     909 .. 0.95
   7 !   29.0   0.1   6.5e-10   1.2e-06       2      37 ..     912     945 ..     911     946 .. 0.90
   8 !   22.6   0.1     7e-08   0.00013       3      33 ..     949     978 ..     947     980 .. 0.89
   9 ?   -1.2   0.0       2.1   3.8e+03      19      37 ..    1018    1036 ..    1005    1037 .. 0.71

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.6
        Sel1   5 yrLG.mfylylnGlgv 19 
                 y LG ++++yl+G+ +
  EFC39859.1 379 YSLGcTILYYLFGK-I 393
                 7799999******8.4 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 7.5
        Sel1  28 ewyekAAe 35 
                 +++e+AA+
  EFC39859.1 538 YYLELAAD 545
                 89*****8 PP

  == domain 3  score: -2.3 bits;  conditional E-value: 4.7
        Sel1  24 ekAiewyekAAeq 36 
                 ++A+ w++k A++
  EFC39859.1 796 DSAVDWLKKCASH 808
                 5799*****8887 PP

  == domain 4  score: -1.0 bits;  conditional E-value: 1.8
        Sel1  28 ewyekAAeqGd 38 
                 ew+ k A +Gd
  EFC39859.1 828 EWFLKGAHLGD 838
                 7******9997 PP

  == domain 5  score: 5.9 bits;  conditional E-value: 0.012
        Sel1  25 kAiewyekAAeqG 37 
                 ++++w ++AA qG
  EFC39859.1 861 QGFYWCKRAAHQG 873
                 59**********9 PP

  == domain 6  score: 30.3 bits;  conditional E-value: 2.6e-10
        Sel1   1 aeAmyrLGmfylylnGlgvpkDpekAiewyekAAeq 36 
                 + A+y +   ++y +Gl v ++pekA++w+++AAe+
  EFC39859.1 875 PRAQYHMS--QCYKYGLAVNRNPEKAFKWMKLAAEN 908
                 57******..************************96 PP

  == domain 7  score: 29.0 bits;  conditional E-value: 6.5e-10
        Sel1   2 eAmyrLGmfylylnGlgvpkDpekAiewyekAAeqG 37 
                  A+y+LG+fy    G+g+ +D++kA++w+e +A++ 
  EFC39859.1 912 VAQYQLGLFY--GGGKGTVQDVKKAFYWLETSAKKK 945
                 59*****777..******************999875 PP

  == domain 8  score: 22.6 bits;  conditional E-value: 7e-08
        Sel1   3 AmyrLGmfylylnGl.gvpkDpekAiewyekA 33 
                 A++ LG  ++y++G+ +v+ +++kAie+++k+
  EFC39859.1 949 ALNELG--LIYMKGRyDVKVNYDKAIEYFKKS 978
                 899***..777****66*************96 PP

  == domain 9  score: -1.2 bits;  conditional E-value: 2.1
        Sel1   19 vpkDpekAiewyekAAeqG 37  
                  +++ +e++iew+ k+ ++G
  EFC39859.1 1018 LKQKREEGIEWMMKSISLG 1036
                  6777899****98887777 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.9   1.3   1.3e-19   2.3e-16       2     257 ..     173     445 ..     172     447 .. 0.75
   2 ?   -1.3   0.1       0.6   1.1e+03      63     114 ..     698     752 ..     662     760 .. 0.72

  Alignments for each domain:
  == domain 1  score: 59.9 bits;  conditional E-value: 1.3e-19
                  EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-B...TTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTC CS
  Pkinase_Tyr   2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkh...pnivkllgvctkeepllivteyvkgGdLlkfLrkke 96 
                  +l+k +G+G++GkV++   +     + ++ a+K + + + ++    + +++k++++++    + i+++l     ++++++vtey ++G+L++   +  
   EFC39859.1 173 KLSKFIGNGTYGKVYHSVDD-----SGYEYAIKEIPALYVDT--MFVENNVKLISECNEtflRYILRILDTFQIANNYYVVTEYFNKGSLNNIR-N-- 260
                  57889**********98877.....999*******8777766..334447888888754122678999999999999*************9964.3.. PP

                  TTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE....TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS.................. CS
  Pkinase_Tyr  97 kekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse....nkvvkisDfGLardiekddeyvkkeeaklpvkWm.................. 172
                  + k++++++l++++q+   +++L+skk+vH d+   N++++     +    ++D GL+r+i+ + + ++ +++  +++ +                  
   EFC39859.1 261 DVKMSVSTILQIIIQMVTSLRFLNSKKMVHLDIKEGNIFVQFfnghRISLILGDLGLSRKINPSIQLNTINNNINNIEIVkeslfeslsssasvgtpl 358
                  47**************************************9644335567789*******96554443333333333222112222222222222222 PP

                  ..-HHHHHHSE..EEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHH.HTTEES-BBTTSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 173 ..apEslkekk..ftsksDvWsfGvllwEiftlgespypglkneevlekl.kegkrlekpekcpeelyelmkkcweedpeeRptfselve 257
                    apE+l++++  + +ksD++s G ++   +  g+  + + ++e   ek+ +  ++le+pe  ++ +yel++k ++ d +eR++ +++++
   EFC39859.1 359 yqAPEMLQQENpfIHEKSDIYSLGCTILYYLF-GKIKVLNQEKELDWEKInSLFQKLEEPE--WKYIYELLQKMLTIDVNERADTKTILD 445
                  227777777769999*********98765444.8888888877777788835567799999..99******************9999876 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.6
                  B--EEEEEE.SSSSEEEEEE--TTE...BHHHHHHHTCTTTSBHHHHHHHHHHHHH CS
  Pkinase_Tyr  63 ivkllgvct.keepllivteyvkgG...dLlkfLrkkekekltlkdllsfalqvAk 114
                  i + + +c+  +    +v++yvk+    + ++fL    ++k+++++++++a ++ +
   EFC39859.1 698 ICQNIDACYyLKYDEKLVMDYVKQTndsNAKTFLLLM-EKKVSMSKMIQLADDIGN 752
                  4555555554344457889998876444788899888.999999999999988876 PP

>> PX  PX domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.0   4.5   7.3e-13   1.3e-09       8      99 ..      16     107 ..       5     120 .. 0.84
   2 ?   -1.8   0.0       1.7     3e+03      67     110 ..     209     250 ..     164     252 .. 0.76

  Alignments for each domain:
  == domain 1  score: 38.0 bits;  conditional E-value: 7.3e-13
                 EEEEEEETTSSEEEEEEEEEETTS......SSEEEEEEEHHHHHHHHHHHHHHHTTSTSTSSSTSGSSSSSCTTSHHHHHHHHHHHHHHHHHHHTSCH CS
          PX   8 vleretsgskkhsyylyevelktg......akewtvkRrYsdFeeLhskLlrkfprvkiPplPkkvlfgsvrkkdeefiekrrkgLeeyLqrllnhpe 99 
                 ++++  +++k ++ y+  ++l++         +w++  rYs++ ++hs L + f+  k+P++P+k+lf +    ++e+iekr  +L++y+++l+++  
  EFC39859.1  16 TITPDDRHTKPYTNYILDISLQSDknpqeiFYQWSIEYRYSQLRSFHSLLSKYFK--KLPTFPPKKLFNR----SSEMIEKRLVELKKYFKQLFKNRN 107
                 44444458999999999999999899999999***********************..***********87....9*******************9865 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 1.7
                 GSSSSSCTTSHHHHHHHHHHHHHHHHHHHTSCHHHH.SHHHHHHH CS
          PX  67 vlfgsvrkkdeefiekrrkgLeeyLqrllnhpelrn.sevlteFL 110
                  +f+    ++ + i +  +++ +y+ r+l   ++ n + v+te++
  EFC39859.1 209 TMFV---ENNVKLISECNETFLRYILRILDTFQIANnYYVVTEYF 250
                 3444...37788888889999999999999999999888888877 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.0       6.3   1.1e+04       4      23 ..     249     268 ..     249     272 .. 0.75
   2 ?   -2.3   0.0       4.1   7.3e+03      15      28 ..     793     806 ..     793     807 .. 0.84
   3 ?   -2.4   0.0       4.4   7.9e+03       3      13 ..     949     959 ..     949     964 .. 0.85
   4 !    6.6   0.1     0.006        11      16      28 ..     967     979 ..     965     981 .. 0.92
   5 !   12.3   0.4   8.8e-05      0.16       3      30 ..    1008    1035 ..    1007    1035 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 6.3
                 HHHHHHHHHHTT-HHHHHHH CS
       TPR_8   4 yynlgsiylklgdyeeAkey 23 
                 y+n+gs+    +d ++++++
  EFC39859.1 249 YFNKGSLNNIRNDVKMSVST 268
                 89999998887777777665 PP

  == domain 2  score: -2.3 bits;  conditional E-value: 4.1
                 T-HHHHHHHHHHHH CS
       TPR_8  15 gdyeeAkeyyekal 28 
                 g  ++A+ +++k+ 
  EFC39859.1 793 GHVDSAVDWLKKCA 806
                 56799*******96 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 4.4
                 HHHHHHHHHHH CS
       TPR_8   3 ayynlgsiylk 13 
                 a++ lg+iy+k
  EFC39859.1 949 ALNELGLIYMK 959
                 57899****86 PP

  == domain 4  score: 6.6 bits;  conditional E-value: 0.006
                 -HHHHHHHHHHHH CS
       TPR_8  16 dyeeAkeyyekal 28 
                 +y++A+ey++k l
  EFC39859.1 967 NYDKAIEYFKKSL 979
                 79*********98 PP

  == domain 5  score: 12.3 bits;  conditional E-value: 8.8e-05
                  HHHHHHHHHHHTT-HHHHHHHHHHHHHH CS
       TPR_8    3 ayynlgsiylklgdyeeAkeyyekalel 30  
                  +y+n+g +y+ +++ ee +e+++k ++l
  EFC39859.1 1008 LYLNIGECYFLKQKREEGIEWMMKSISL 1035
                  69***********************997 PP

>> TPR_1  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.8   0.1      0.27   4.8e+02       3      13 ..     949     959 ..     947     960 .. 0.90
   2 !   11.9   0.3   8.5e-05      0.15      16      30 ..     967     981 ..     962     985 .. 0.87
   3 !    5.4   0.1    0.0094        17       3      22 ..    1008    1027 ..    1007    1035 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.8 bits;  conditional E-value: 0.27
                 HHHHHHHHHHH CS
       TPR_1   3 alynlGnayfk 13 
                 al+ lG++y+k
  EFC39859.1 949 ALNELGLIYMK 959
                 99*******97 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 8.5e-05
                 -HHHHHHHHHHHHHH CS
       TPR_1  16 kydeAleyyekALel 30 
                 +yd+A+ey++k L+ 
  EFC39859.1 967 NYDKAIEYFKKSLQT 981
                 8***********985 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.0094
                  HHHHHHHHHHHTT-HHHHHH CS
       TPR_1    3 alynlGnayfklgkydeAle 22  
                   + n+G +yf ++k +e +e
  EFC39859.1 1008 LYLNIGECYFLKQKREEGIE 1027
                  699**********9998777 PP

>> TPR_12  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1     0.086   1.5e+02      46      71 ..     780     805 ..     771     808 .. 0.87
   2 ?   -2.6   0.0         4   7.1e+03      47      62 ..     949     963 ..     948     964 .. 0.80
   3 !    6.5   0.0    0.0058        10      18      35 ..     967     984 ..     966     990 .. 0.68
   4 ?    3.7   0.0     0.042        75       6      31 ..    1009    1034 ..    1006    1038 .. 0.87

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.086
      TPR_12  46 ttlrnLgrlyralgryeeAlelleea 71 
                 +++  L+r++++ g+ + A+++l+++
  EFC39859.1 780 QAQLILARWLQMYGHVDSAVDWLKKC 805
                 667779*****************997 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 4
      TPR_12  47 tlrnLgrlyralgrye 62 
                 +l+ Lg +y + gry+
  EFC39859.1 949 ALNELGLIY-MKGRYD 963
                 688899998.888887 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.0058
      TPR_12  18 rydeAlellekaleiarr 35 
                 +yd+A+e+++k+l+  + 
  EFC39859.1 967 NYDKAIEYFKKSLQTLED 984
                 577777777777776554 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.042
      TPR_12    6 lnnlaavlrrlgrydeAlellekale 31  
                  + n++++++  ++ +e +e+  k++ 
  EFC39859.1 1009 YLNIGECYFLKQKREEGIEWMMKSIS 1034
                  679*****999999******999976 PP

>> TPR_2  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0       1.2   2.1e+03       7      28 ..     785     806 ..     780     809 .. 0.85
   2 ?   -3.4   0.0       8.5   1.5e+04      14      28 ..     892     906 ..     889     907 .. 0.78
   3 ?   -0.1   0.1      0.73   1.3e+03       3      13 ..     949     959 ..     947     963 .. 0.81
   4 ?    8.6   0.2    0.0012       2.2      16      29 ..     967     980 ..     967     985 .. 0.89
   5 ?    6.2   0.1     0.007        12       3      30 ..    1008    1035 ..    1006    1037 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 1.2
       TPR_2   7 lGlayyklgdyeeAleafekAl 28 
                 l++ +   g+ + A+++++k+ 
  EFC39859.1 785 LARWLQMYGHVDSAVDWLKKCA 806
                 88889999***********986 PP

  == domain 2  score: -3.4 bits;  conditional E-value: 8.5
       TPR_2  14 lgdyeeAleafekAl 28 
                 + ++e+A ++++ A 
  EFC39859.1 892 NRNPEKAFKWMKLAA 906
                 578999999988775 PP

  == domain 3  score: -0.1 bits;  conditional E-value: 0.73
       TPR_2   3 alynlGlayyk 13 
                 al++lGl+y+k
  EFC39859.1 949 ALNELGLIYMK 959
                 899******95 PP

  == domain 4  score: 8.6 bits;  conditional E-value: 0.0012
       TPR_2  16 dyeeAleafekAle 29 
                 +y++A+e+f+k+l+
  EFC39859.1 967 NYDKAIEYFKKSLQ 980
                 8***********98 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.007
       TPR_2    3 alynlGlayyklgdyeeAleafekAlel 30  
                  ++ n+G++y+ +++ ee +e++ k+++l
  EFC39859.1 1008 LYLNIGECYFLKQKREEGIEWMMKSISL 1035
                  799******************9998876 PP

>> TPR_7  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       6.6   1.2e+04      17      32 ..     672     685 ..     671     687 .. 0.70
   2 ?   12.1   0.1   8.8e-05      0.16       1      30 [.     949     983 ..     949     996 .. 0.75
   3 ?   -1.5   0.0       1.9   3.4e+03       2      17 ..    1009    1024 ..    1008    1024 .. 0.85

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 6.6
       TPR_7  17 eAielyeqsLaltkdp 32 
                 +A+++ e+  a+++++
  EFC39859.1 672 RAVKVDER--AIEYAD 685
                 68888888..777665 PP

  == domain 2  score: 12.1 bits;  conditional E-value: 8.8e-05
       TPR_7   1 aLlnLarlysr.....lGdyeeAielyeqsLaltk 30 
                 aL+ L+ +y +       +y++Aie++++sL++ +
  EFC39859.1 949 ALNELGLIYMKgrydvKVNYDKAIEYFKKSLQTLE 983
                 5677777777766666679************5544 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1.9
       TPR_7    2 LlnLarlysrlGdyee 17  
                  +ln++++y+  +++ee
  EFC39859.1 1009 YLNIGECYFLKQKREE 1024
                  89******99888875 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1084 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       743  (0.0414412); expected 358.6 (0.02)
Passed bias filter:                      323  (0.0180155); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.75u 0.32s 00:00:01.07 Elapsed: 00:00:00.47
# Mc/sec: 6868.77
//
Query:       EFC39860.1  [L=409]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    0.00014   21.1   6.6     0.0002   20.7   6.6    1.2  1  G-alpha        G-protein alpha subunit
  ------ inclusion threshold ------
      0.011   16.0   1.1        5.3    7.4   0.0    2.8  2  GIY-YIG        GIY-YIG catalytic domain
       0.11   12.7   0.0       0.24   11.6   0.0    1.5  1  OCRL_clath_bd  Inositol polyphosphate 5-phosphatase clathrin 


Domain annotation for each model (and alignments):
>> G-alpha  G-protein alpha subunit
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.7   6.6   3.3e-08    0.0002     204     344 ..     117     262 ..      43     271 .. 0.79

  Alignments for each domain:
  == domain 1  score: 20.7 bits;  conditional E-value: 3.3e-08
                 EEEEEE-SSH.HHHHGTCCCTTTECEEEEEEEGGGTT-B-SS-TTSBHHHHHHHHHHCCCC-GGGTTSEEEEEEE-HHHHHHHC..CCS-GGGCCTT-- CS
     G-alpha 204 frivdvgGqr.serkkWvpffddvdaiiFlvslsefdqvlyedekvnrleeslklFkeicnnkllkntpiiLflnKlDileeKl..kkgklskyfpsye 299
                 ++ +++ G r +  + W ++ +++++ i + sl  fd+  +   ++  + +s+ + ke +++k  k+ +i+++++  D+l eK   ++++l++  +  +
  EFC39860.1 117 VKKYTTLGNRqARLRRWQELNSNAKFGIVIQSLISFDHPFEF--SEYEFFDSIGIIKEYLTHKASKELRIVFMFTMADLLYEKStfQSKNLKEPTR--D 211
                 4445556777366699**********************6655..468999*********************************9664557777321..1 PP

                 ...........H.CCHHHHHHHHHHHHHHCCCCCCESGGSCEEEEEE-TT-HHHHH CS
     G-alpha 300 ...........grkndlesvlkylrnkFeeihkeksnnrrkiythftsatdtkevq 344
                            ++ + ++svl++ +n Fe +     ++++k+ +h+++ + t+e  
  EFC39860.1 212 rielkhignmnKERDLINSVLDFYQNVFETF-----RENEKFEYHIINNLSTDESY 262
                 2234444444388888**************9.....56669*****9977776654 PP

>> GIY-YIG  GIY-YIG catalytic domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.4   0.0   0.00089       5.3      25      57 ..     131     166 ..     123     182 .. 0.90
   2 ?    6.4   0.3    0.0018        11      44      75 ..     228     260 ..     202     263 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.4 bits;  conditional E-value: 0.00089
                 HHHHHHHHHHHHT--S-H...S.STEEEEEEEE--- CS
     GIY-YIG  25 kRlkqHnagkkakytrkk...gkkpfeliileifpt 57 
                 +R+++ n+++k ++ ++    +  pfe++ +e+f++
  EFC39860.1 131 RRWQELNSNAKFGIVIQSlisFDHPFEFSEYEFFDS 166
                 8********************9***********986 PP

  == domain 2  score: 6.4 bits;  conditional E-value: 0.0018
                 .STEEEEEEEE----HHHHHHHHHHHHHHTT.S CS
     GIY-YIG  44 kkpfeliileifptksealelEkklikkyks.n 75 
                 ++++  ++  +f+t++e  ++E+++i+++++ +
  EFC39860.1 228 INSVLDFYQNVFETFRENEKFEYHIINNLSTdE 260
                 66777778899999*************997754 PP

>> OCRL_clath_bd  Inositol polyphosphate 5-phosphatase clathrin binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0     4e-05      0.24      61      87 ..      84     110 ..      78     120 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 4e-05
  OCRL_clath_bd  61 distnsgvkiRvrgerapelllElqDd 87 
                    +is+n+   iR++g+r++el lE+ ++
     EFC39860.1  84 EISMNQLKFIRIQGDRTRELKLEIGNE 110
                    578888888***************877 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (409 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       757  (0.0422221); expected 358.6 (0.02)
Passed bias filter:                      432  (0.024095); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.48u 0.26s 00:00:00.74 Elapsed: 00:00:00.41
# Mc/sec: 3020.92
//
Query:       EFC39861.1  [L=197]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.7e-09   35.7   0.0    1.6e-08   35.0   0.0    1.3  1  Ank_2     Ankyrin repeats (3 copies)
    3.7e-08   33.5   0.1    7.3e-08   32.5   0.1    1.5  1  Ank       Ankyrin repeat
      7e-08   32.6   0.0    1.3e-07   31.7   0.0    1.4  1  Ank_5     Ankyrin repeats (many copies)
    2.3e-06   27.5   0.0    1.1e-05   25.4   0.0    2.1  2  Ank_3     Ankyrin repeat
    1.1e-05   25.9   0.0    2.4e-05   24.8   0.0    1.6  1  Ank_4     Ankyrin repeats (many copies)


Domain annotation for each model (and alignments):
>> Ank_2  Ankyrin repeats (3 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.0   0.0   4.5e-12   1.6e-08      37      80 ..      64     110 ..      53     126 .. 0.75

  Alignments for each domain:
  == domain 1  score: 35.0 bits;  conditional E-value: 4.5e-12
       Ank_2  37 gnl.eivklLleh..adndgrtpLhyAarsghleivklLlekgadin 80 
                 ++l e++k +l+   +d + +tpLh+A+r+gh+ +vklLlekgad+ 
  EFC39861.1  64 NSLnEFIKQFLSIktQDVNSQTPLHLAVREGHTSCVKLLLEKGADPL 110
                 33336777777734677778888888888888888888888888875 PP

>> Ank  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.5   0.1     2e-11   7.3e-08       3      31 ..      84     113 ..      82     114 .. 0.93

  Alignments for each domain:
  == domain 1  score: 32.5 bits;  conditional E-value: 2e-11
                 BBHHHHHHHHTTHHHHHHHH.TTTSTTCBT CS
         Ank   3 nTPLHlAatngkkriiklLL.hGAnlnald 31 
                  TPLHlA+++g+++++klLL +GA++ ++d
  EFC39861.1  84 QTPLHLAVREGHTSCVKLLLeKGADPLSVD 113
                 6*******************99***98887 PP

>> Ank_5  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   31.7   0.0   3.6e-11   1.3e-07      12      55 ..      79     122 ..      71     123 .. 0.91

  Alignments for each domain:
  == domain 1  score: 31.7 bits;  conditional E-value: 3.6e-11
       Ank_5  12 ldgggntpLhvAakygaadvvrlLlargadlnltdsrGltaldl 55 
                 +d +++tpLh+A++ g+ ++v+lLl+ gad+   d  G+t++d+
  EFC39861.1  79 QDVNSQTPLHLAVREGHTSCVKLLLEKGADPLSVDHIGKTVVDY 122
                 566677*************************************8 PP

>> Ank_3  Ankyrin repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.2   0.0       1.4     5e+03      13      30 ..      64      82 ..      56      83 .. 0.66
   2 !   25.4   0.0     3e-09   1.1e-05       2      29 ..      83     109 ..      82     111 .. 0.93

  Alignments for each domain:
  == domain 1  score: -1.2 bits;  conditional E-value: 1.4
       Ank_3 13 gnl.eivkfLlenkgadvn 30
                ++l e +k +l +k  dvn
  EFC39861.1 64 NSLnEFIKQFLSIKTQDVN 82
                3333478888888888887 PP

  == domain 2  score: 25.4 bits;  conditional E-value: 3e-09
       Ank_3   2 GetpLhlAarsgnleivkfLlenkgadv 29 
                  +tpLhlA+r g+++ vk+Lle kgad+
  EFC39861.1  83 SQTPLHLAVREGHTSCVKLLLE-KGADP 109
                 58********************.9***8 PP

>> Ank_4  Ankyrin repeats (many copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   24.8   0.0   6.6e-09   2.4e-05       3      41 ..      85     122 ..      67     129 .. 0.91

  Alignments for each domain:
  == domain 1  score: 24.8 bits;  conditional E-value: 6.6e-09
       Ank_4   3 taLhyaaisgrlelvrlLlekgadinaqdnrsGetalhi 41 
                 t+Lh a+ +g++ +v+lLlekgad+  + +  G t +++
  EFC39861.1  85 TPLHLAVREGHTSCVKLLLEKGADPLSV-DHIGKTVVDY 122
                 7899999999999999999999999999.8889988876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (197 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       947  (0.0528195); expected 358.6 (0.02)
Passed bias filter:                      452  (0.0252106); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.45u 0.24s 00:00:00.69 Elapsed: 00:00:00.42
# Mc/sec: 1397.35
//
Query:       EFC39862.1  [L=122]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (122 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       376  (0.0209716); expected 358.6 (0.02)
Passed bias filter:                      310  (0.0172904); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.39u 0.26s 00:00:00.65 Elapsed: 00:00:00.43
# Mc/sec: 858.11
//
Query:       EFC39863.1  [L=180]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.8e-06   26.5   0.0    9.7e-06   25.6   0.0    1.4  1  CMD        Carboxymuconolactone decarboxylase family
  ------ inclusion threshold ------
       0.02   14.8   0.2       0.16   11.9   0.0    2.4  3  Pou        Pou domain - N-terminal to homeobox domain
      0.082   12.8   0.3        1.3    8.9   0.0    2.6  3  EF-hand_8  EF-hand domain pair
       0.17   12.2   0.0        1.4    9.3   0.0    2.1  2  DUF2929    Protein of unknown function (DUF2929)


Domain annotation for each model (and alignments):
>> CMD  Carboxymuconolactone decarboxylase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   25.6   0.0   2.2e-09   9.7e-06      20      62 ..      47      90 ..      36      93 .. 0.90

  Alignments for each domain:
  == domain 1  score: 25.6 bits;  conditional E-value: 2.2e-09
                TS-HHHHHHHHHHHHHHTT-HHHHHHHHHHHH.HTT--HHHHHH CS
         CMD 20 gLdpkereLialavsaangceyCvdaHtraAl.eaGvteeeiae 62
                 L+  +r+++   +s +ng eyC ++H++ ++ +aG t ee+ e
  EFC39863.1 47 TLTFIQRHIVEYIASSMNGDEYCTQMHAKFLKtKAGFTNEELLE 90
                577789***********************************987 PP

>> Pou  Pou domain - N-terminal to homeobox domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.41   1.8e+03      12      36 ..      40      64 ..      36      76 .. 0.72
   2 ?   11.9   0.0   3.6e-05      0.16      37      60 ..     119     143 ..     110     148 .. 0.84
   3 ?   -1.7   0.0      0.66     3e+03      33      45 ..     166     178 ..     158     179 .. 0.73

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.41
         Pou 12 efkqkRiklgltQadvglaLgklyg 36
                ++k++  +l++ Q  + + +++ ++
  EFC39863.1 40 NLKKEHATLTFIQRHIVEYIASSMN 64
                5788888999999888777766553 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 3.6e-05
         Pou  37 k.efSqttIcrFEkLdlslknmlkl 60 
                 k ++Sq  I+ FE+++++  +m+++
  EFC39863.1 119 KgKLSQEDISTFENMKITRDQMYEI 143
                 3377*****************9976 PP

  == domain 3  score: -1.7 bits;  conditional E-value: 0.66
         Pou  33 klygkefSqttIc 45 
                 + + +++Sqtt  
  EFC39863.1 166 ERFCDNVSQTTTT 178
                 5566788999876 PP

>> EF-hand_8  EF-hand domain pair
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.0   0.0      0.74   3.3e+03      20      28 ..      79      88 ..      71      91 .. 0.58
   2 ?    0.5   0.0      0.12   5.6e+02      38      48 ..     117     127 ..     116     130 .. 0.73
   3 ?    8.9   0.0   0.00029       1.3       1      20 [.     131     150 ..     131     158 .. 0.85

  Alignments for each domain:
  == domain 1  score: -2.0 bits;  conditional E-value: 0.74
   EF-hand_8 20 kk.glseeev 28
                 k g+++ee+
  EFC39863.1 79 TKaGFTNEEL 88
                3346777775 PP

  == domain 2  score: 0.5 bits;  conditional E-value: 0.12
   EF-hand_8  38 dgdGkisfeEF 48 
                 +++Gk+s+e+ 
  EFC39863.1 117 NKKGKLSQEDI 127
                 67888888875 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.00029
   EF-hand_8   1 ekgkItreelrrilrilglk 20 
                 e++kItr+ +++i+++++lk
  EFC39863.1 131 ENMKITRDQMYEIITSIHLK 150
                 589***********888998 PP

>> DUF2929  Protein of unknown function (DUF2929)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.0   0.0      0.24   1.1e+03      16      33 ..      14      31 ..      12      35 .. 0.79
   2 ?    9.3   0.0   0.00031       1.4      10      29 ..      49      68 ..      49      74 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.0 bits;  conditional E-value: 0.24
     DUF2929 16 vvgYIgsaLtgvtydftt 33
                + g+I ++L ++  d+ t
  EFC39863.1 14 MFGFIPNSLAEMCKDPFT 31
                89*******998666655 PP

  == domain 2  score: 9.3 bits;  conditional E-value: 0.00031
     DUF2929 10 sfiLgevvgYIgsaLtgvty 29
                +fi  ++v YI+s+++g +y
  EFC39863.1 49 TFIQRHIVEYIASSMNGDEY 68
                678889***********988 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (180 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       741  (0.0413297); expected 358.6 (0.02)
Passed bias filter:                      419  (0.02337); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.48u 0.33s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 1113.29
//
Query:       EFC39864.1  [L=765]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    8.9e-06   25.4   4.6        1.2    9.4   0.1    4.6  4  LRR_6          Leucine Rich repeat
     0.0011   19.2   0.7         59    4.8   0.0    4.8  3  LRR_1          Leucine Rich Repeat
  ------ inclusion threshold ------
      0.049   14.2   7.6       0.34   11.6   7.6    2.6  1  SlyX           SlyX
       0.12   12.6   0.0       0.38   11.1   0.0    1.8  1  NAAA-beta      beta subunit of N-acylethanolamine-hydrolyzing
        0.5    9.0   4.4       0.83    8.3   4.4    1.3  1  Tweety         Tweety
        1.7    9.1   4.0         10    6.6   1.6    2.6  2  FAA_hydro_N_2  Fumarylacetoacetase N-terminal domain 2


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   0.0     0.014        42       2      18 ..     354     370 ..     353     371 .. 0.92
   2 ?    2.6   0.1     0.058   1.7e+02       4      18 ..     384     398 ..     383     399 .. 0.88
   3 !    7.3   0.0    0.0019       5.6       5      22 ..     436     453 ..     434     455 .. 0.83
   4 !    9.4   0.1    0.0004       1.2       2      23 ..     461     482 ..     460     483 .. 0.88

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.014
       LRR_6   2 nthLteLdLsgNdIgDe 18 
                 +++L+ L+L+  ++gDe
  EFC39864.1 354 KSSLRCLSLKNTGLGDE 370
                 589*************8 PP

  == domain 2  score: 2.6 bits;  conditional E-value: 0.058
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 +L +L +sg++++D+
  EFC39864.1 384 KLSKLTVSGCCLSDD 398
                 578999*******97 PP

  == domain 3  score: 7.3 bits;  conditional E-value: 0.0019
       LRR_6   5 LteLdLsgNdIgDeGaea 22 
                 Lt+LdLs+N ++D+ a+a
  EFC39864.1 436 LTSLDLSDNYFSDSTAKA 453
                 9********998876665 PP

  == domain 4  score: 9.4 bits;  conditional E-value: 0.0004
       LRR_6   2 nthLteLdLsgNdIgDeGaeaL 23 
                 +++L++L+Ls N Ig  G++ +
  EFC39864.1 461 DQTLKKLNLSKNIIGVTGISLF 482
                 58*************9999865 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.3     0.031        93       1      23 []     384     406 ..     384     406 .. 0.88
   2 ?    4.3   0.0     0.028        84       2      16 ..     436     450 ..     435     457 .. 0.81
   3 ?    4.8   0.0      0.02        59       2      14 ..     464     476 ..     463     487 .. 0.79

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.031
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +L +L +s+++l++ +++++ nL
  EFC39864.1 384 KLSKLTVSGCCLSDDSSQYILNL 406
                 68899*******99999988876 PP

  == domain 2  score: 4.3 bits;  conditional E-value: 0.028
       LRR_1   2 LrhLdLsnnpllglp 16 
                 L++LdLs+n +++ +
  EFC39864.1 436 LTSLDLSDNYFSDST 450
                 89*******997655 PP

  == domain 3  score: 4.8 bits;  conditional E-value: 0.02
       LRR_1   2 LrhLdLsnnpllg 14 
                 L++L+Ls n+++ 
  EFC39864.1 464 LKKLNLSKNIIGV 476
                 9********9943 PP

>> SlyX  SlyX
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   7.6   0.00011      0.34       9      58 ..     661     710 ..     659     730 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 0.00011
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHT-XXXXXXXXXXX CS
        SlyX   9 EiklafqedtieeLndvvaeqqqqidrlqrqlrllaerlkeleessgase 58 
                 E ++  qe+ + +L++++++  q + +lq++ + l+++l + +e+ ++s+
  EFC39864.1 661 ENRIQSQERSLTDLQQALVQLTQLVNELQEEKQTLNKQLIDTNEKLEKSQ 710
                 779999*********************************77777766554 PP

>> NAAA-beta  beta subunit of N-acylethanolamine-hydrolyzing acid amidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.1   0.0   0.00013      0.38       5      28 ..     215     238 ..     212     245 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.1 bits;  conditional E-value: 0.00013
   NAAA-beta   5 wytinLDlpPeeRWtqvakdykpe 28 
                  + i+LDl P+e+W+  +++ k +
  EFC39864.1 215 LFEIDLDLIPQEHWKRCLAALKNS 238
                 699***********9988887765 PP

>> Tweety  Tweety
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   4.4   0.00028      0.83     279     342 ..     656     724 ..     642     734 .. 0.80

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00028
      Tweety 279 npFq..qrLtesqkaltemqeqveellriavelfptae...kkLlaiqellnsternlhqLtAlldcrs 342
                 n+F+   r+++ +++lt++q+++ +l++   el ++ +   k+L   +e l+++++n++ Lt +++  s
  EFC39864.1 656 NKFEneNRIQSQERSLTDLQQALVQLTQLVNELQEEKQtlnKQLIDTNEKLEKSQTNVQSLTSIVEANS 724
                 666422577888899999999888888887766655555559**********************98765 PP

>> FAA_hydro_N_2  Fumarylacetoacetase N-terminal domain 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.14   4.1e+02      40      58 ..     226     244 ..     224     257 .. 0.90
   2 ?    6.6   1.6    0.0034        10      32      71 ..     671     710 ..     659     713 .. 0.85

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.14
  FAA_hydro_N_2  40 dnWdevepaLeelyeaLna 58 
                    ++W+++ +aL++  +++n+
     EFC39864.1 226 EHWKRCLAALKNSRQSFNS 244
                    89************99986 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0034
  FAA_hydro_N_2  32 aptlqaaLdnWdevepaLeelyeaLnagtakeafafdpee 71 
                     + lq+aL + +++ ++L+e+ ++Ln++  ++ +++++++
     EFC39864.1 671 LTDLQQALVQLTQLVNELQEEKQTLNKQLIDTNEKLEKSQ 710
                    678************************9999999998876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (765 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2792  (0.155725); expected 358.6 (0.02)
Passed bias filter:                      472  (0.0263261); expected 358.6 (0.02)
Passed Vit filter:                        79  (0.00440627); expected 17.9 (0.001)
Passed Fwd filter:                        20  (0.00111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.94u 0.34s 00:00:01.28 Elapsed: 00:00:00.58
# Mc/sec: 3961.53
//
Query:       EFC39865.1  [L=321]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.3e-05   25.0   0.7    3.6e-05   23.7   0.0    2.2  2  SNARE           SNARE domain
  ------ inclusion threshold ------
      0.017   14.8  30.0      0.024   14.3   0.2    3.2  3  Syntaxin        Syntaxin
      0.066   13.2   0.9       0.27   11.2   0.0    2.3  2  T2SSF           Type II secretion system (T2SS), protein F


Domain annotation for each model (and alignments):
>> SNARE  SNARE domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.9   0.2       1.2   7.1e+03      13      27 ..      52      66 ..      47      72 .. 0.50
   2 !   23.7   0.0   6.1e-09   3.6e-05       4      52 ..     267     315 ..     264     316 .. 0.97

  Alignments for each domain:
  == domain 1  score: -2.9 bits;  conditional E-value: 1.2
                HHHHHHHHHHHHHHH CS
       SNARE 13 aqsnveraqkeLkka 27
                ++  +++ ++ L+k 
  EFC39865.1 52 VSKELQETADLLQKL 66
                333444444555554 PP

  == domain 2  score: 23.7 bits;  conditional E-value: 6.1e-09
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHCTXXXXXXXXXXXXXXXXXXX CS
       SNARE   4 DrIdtnVenaqsnveraqkeLkkavkyqksnRklkciillilviillvv 52 
                 +rId+n  +a  ++e++++eL  + ++ + n  l  + +++lvi++++v
  EFC39865.1 267 QRIDQNLTTAAHDLEQGKEELWNVWENTRGNTGLILKVFGVLVIFIIIV 315
                 79*********************************************98 PP

>> Syntaxin  Syntaxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   9.6     0.031   1.8e+02      23      86 ..      11      77 ..       5      96 .. 0.59
   2 ?    9.6  13.7   0.00011      0.65       3     126 ..      44     163 ..      42     172 .. 0.88
   3 ?   14.3   0.2     4e-06     0.024     133     199 ..     203     262 ..     198     263 .. 0.74

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.031
    Syntaxin 23 kklkkqneesktstraksvk.lkkrmesd..ikeikkraesvkarLeaLdksnkenekksgegsavd 86
                +++ +++++ k+  ++++vk +kk++++d  ++e + +a++v ++L++  +  ++  k  +++++ d
  EFC39865.1 11 QSIIQNQQQKKQYEQSETVKkTKKKSDKDvtVAEFNGKARQVSKELQETADLLQKLTKLVKKKTPFD 77
                4444455555555555555555555555411567888888899998888888777777766666554 PP

  == domain 2  score: 9.6 bits;  conditional E-value: 0.00011
    Syntaxin   3 effkeveeikkeiekleeevkklkkqneesktstraksvklkkrmesdikeikkraesvkarLeaLdksnkenekksgegsavdRirksqtaaLrkklk 101
                 ef  ++++++ke+++ +++++kl+k  ++     +++++     ++s++ ++k++  +    L++L++ ++++++k+++++ ++  ++++ ++L++kl 
  EFC39865.1  44 EFNGKARQVSKELQETADLLQKLTKLVKKKTPFDDNSEL-----IKSLTLKVKEQLSNQDYSLRSLQEIVDKKQEKEKKSNQQTQHSTQIITGLNSKLL 137
                 577788999999999999999999998887777777777.....66779999999999999********9999999999999***************** PP

    Syntaxin 102 evmteynelrekireeykerieRr.l 126
                  + ++++++ ++ ++++k+  +Rr +
  EFC39865.1 138 YATEQFQNVLKTRTTQMKTDKKRRnM 163
                 *******************9999965 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 4e-06
    Syntaxin 133 vseeeieelietgesevflqkllqeqrgarealsei.eeRhkevlelekslkeLhqlFldmavLVEeQ 199
                 +++e+i+eli++g+      +l  +q  a +  ++i  +R +++l++e+++++L  +F  +a+++ + 
  EFC39865.1 203 IQNEKIDELISEGS------QL--QQANASSINRNIlASRTDDILSIEREVEKLGGMFNHLAMMIKSH 262
                 67899999999996......22..122222222333489*************************9765 PP

>> T2SSF  Type II secretion system (T2SS), protein F
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.4   0.2      0.17     1e+03      68      98 ..      88     118 ..      41     123 .. 0.52
   2 ?   11.2   0.0   4.6e-05      0.27      46     123 ..     239     315 ..     206     318 .. 0.88

  Alignments for each domain:
  == domain 1  score: -0.4 bits;  conditional E-value: 0.17
                 HHHHHHHT-HHHHHHHHHHHHHHHHHHHHHH CS
       T2SSF  68 irageeggnLaevLerlaeyleeerelrrkl 98 
                 + + e+ +n +  L+ l+e + +++e ++k+
  EFC39865.1  88 LKVKEQLSNQDYSLRSLQEIVDKKQEKEKKS 118
                 4455666666666777777777776666665 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 4.6e-05
                 SSHHHHHCT-TT.TS-HHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHHHHHHHHHHHTTXXXXXXXXXXXXXXXXXX CS
       T2SSF  46 gslsealertpssefpelvvqlirageeggnLaevLerlaeyleeerelrrkllaallepllllvvallvllillail 123
                  s+++ +e+ +   f  l++++ + ge ++++++ L  +a++le+  e  ++++ ++ +   l++ ++ vl+i+++i+
  EFC39865.1 239 LSIEREVEKLGG-MFNHLAMMIKSHGELTQRIDQNLTTAAHDLEQGKEELWNVWENTRGNTGLILKVFGVLVIFIIIV 315
                 466677777776.88********************************************9999999999999999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (321 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3978  (0.221875); expected 358.6 (0.02)
Passed bias filter:                      674  (0.0375927); expected 358.6 (0.02)
Passed Vit filter:                        69  (0.00384851); expected 17.9 (0.001)
Passed Fwd filter:                        17  (0.000948185); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.78u 0.37s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 1744.46
//
Query:       EFC39866.1  [L=700]
Description: rho family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.7e-33  113.8   0.0      1e-32  113.0   0.0    1.4  1  Ras         Ras family
    1.3e-22   79.5   0.0    5.5e-06   26.3   0.0    6.3  6  Kelch_4     Galactose oxidase, central domain
    3.1e-21   75.2   0.0    2.6e-05   24.4   0.0    5.5  7  Kelch_3     Galactose oxidase, central domain
    2.7e-19   68.7   0.4     0.0025   17.8   0.0    5.4  5  Kelch_5     Kelch motif
    3.2e-14   52.6   0.6     0.0015   18.8   0.0    5.8  5  Kelch_6     Kelch motif
    8.9e-14   51.7   0.0    1.9e-13   50.7   0.0    1.6  1  Roc         Ras of Complex, Roc, domain of DAPkinase
    2.5e-13   49.4   0.9    0.00012   21.6   0.0    5.8  6  Kelch_1     Kelch motif
    2.1e-08   33.8   4.7      0.076   13.0   0.0    5.6  7  Kelch_2     Kelch motif
    7.3e-05   22.5   1.9    0.00022   21.0   1.9    1.8  1  F-box       F-box domain
     0.0014   18.2   0.0     0.0026   17.3   0.0    1.5  1  GTP_EFTU    Elongation factor Tu GTP binding domain
      0.003   17.4   0.3     0.0073   16.2   0.3    1.6  1  F-box-like  F-box-like
  ------ inclusion threshold ------
      0.018   14.8   0.0        0.5   10.1   0.0    2.5  2  PduV-EutP   Ethanolamine utilisation - propanediol utilisatio


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  113.0   0.0   6.7e-36     1e-32       1     160 [.     508     682 ..     508     684 .. 0.97

  Alignments for each domain:
  == domain 1  score: 113.0 bits;  conditional E-value: 6.7e-36
                 EEEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHH.HHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvk.kwveeik 98 
                 K+vl+G+ a+GKt++         + +y++T+ +d+y+ +++ ++ + ++ +wDTAGq ++++lr+l+y +++ +l+ +   s+ s ++   kw +ei+
  EFC39866.1 508 KVVLIGNAAIGKTCFYQALRGIPLELDYIPTV-FDNYSVQCHSEDVTFNIALWDTAGQADYDRLRPLSYPQTDIFLVGFCCLSELSMKETIyKWKKEIE 605
                 9*******************************.******************************************************87655******* PP

                 HHST.TTSEEEEEEETTTGGG.............G-SS-HHHHHHHHHHHT.SEEEEEBTTTTCTHHHHHHHHHHHH CS
         Ras  99 rvae.envpivLvGnKvDlee.............kravsteegeelakelg.lkfletSAktnenveeafeellrei 160
                 ++++  ++pi+L+ +K+Dl++             k+ +s++ege la++lg ++++etSA tn +++ + e +++++
  EFC39866.1 606 TYMPdIKLPIILMSTKIDLRDdpvqsrkllvtemKKPISYQEGELLARKLGcATYVETSALTNAGMDRICELIIKTV 682
                 ***97579*******************************************999***************99999876 PP

>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.4   0.0   0.00069         1       2      44 ..      11      60 ..      10      69 .. 0.79
   2 !   13.2   0.0   4.6e-05     0.069      10      45 ..      83     118 ..      71     123 .. 0.85
   3 !   26.3   0.0   3.7e-09   5.5e-06       1      44 [.     126     169 ..     126     174 .. 0.90
   4 !   17.9   0.0   1.5e-06    0.0023       1      38 [.     177     214 ..     177     214 .. 0.89
   5 ?    1.5   0.0       0.2     3e+02       2      25 ..     237     263 ..     236     273 .. 0.81
   6 ?    2.0   0.0      0.15   2.2e+02      16      27 ..     322     333 ..     315     336 .. 0.86

  Alignments for each domain:
  == domain 1  score: 9.4 bits;  conditional E-value: 0.00069
     Kelch_4  2 Raghsatsi.....pdgtiylfGGrgedg..tllndlylldlstntWrrl 44
                R ghs++        ++ +y+fGG  +d    ++ndl  +++++ +W++ 
  EFC39866.1 11 RTGHSCVLYnshhhKNNCVYMFGGTLSDQktFPSNDLIEINVENQEWKEF 60
                667777776555556689*********9999999*************865 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 4.6e-05
     Kelch_4  10 ipdgtiylfGGrgedgtllndlylldlstntWrrlg 45 
                  +d++ ++fGG + +  l n ++ +++  ++W+ l+
  EFC39866.1  83 HDDNEMIIFGGKSKKKHLQNKVWSFNFYRKEWKCLS 118
                 48999***************************9983 PP

  == domain 3  score: 26.3 bits;  conditional E-value: 3.7e-09
     Kelch_4   1 pRaghsatsipdgtiylfGGrgedgtll.ndlylldlstntWrrl 44 
                 pR+ghs ++ + +t+++fGG  e+ +l+ n+l +++l++++W+ +
  EFC39866.1 126 PRFGHSGVVFG-NTLFVFGGLDEKKKLCrNELIAFNLKSKQWKLI 169
                 9*********6.9***********96655999**********865 PP

  == domain 4  score: 17.9 bits;  conditional E-value: 1.5e-06
     Kelch_4   1 pRaghsatsipd.gtiylfGGrgedgtllndlylldlst 38 
                 +R++h+++ +p  g+ ylfGG++++  +lnd  ++ lst
  EFC39866.1 177 GRCHHASVLDPEsGDWYLFGGQSGK-NVLNDFVRIKLST 214
                 59********777************.6****88887775 PP

  == domain 5  score: 1.5 bits;  conditional E-value: 0.2
     Kelch_4   2 Raghsatsi...pdgtiylfGGrgedg 25 
                 R+ghs++      + ++y +GG++ + 
  EFC39866.1 237 RFGHSMVLEkfeSGLKFYSIGGYNMKK 263
                 999999999885557*******99765 PP

  == domain 6  score: 2.0 bits;  conditional E-value: 0.15
     Kelch_4  16 ylfGGrgedgtl 27 
                 ++fGG +e++++
  EFC39866.1 322 FVFGGLYENTKP 333
                 79******9765 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1         6   8.9e+03      39      48 ..       9      18 ..       8      19 .. 0.82
   2 !   19.6   0.0   5.6e-07   0.00084       1      48 [.      26      77 ..      26      78 .. 0.87
   3 !   16.4   0.0   5.5e-06    0.0082       1      49 []      85     135 ..      85     135 .. 0.84
   4 !   24.4   0.0   1.8e-08   2.6e-05       1      47 [.     136     184 ..     136     186 .. 0.91
   5 !    7.7   0.0    0.0029       4.4       5      30 ..     193     223 ..     190     244 .. 0.70
   6 ?   -2.8   0.0       5.6   8.4e+03       3      26 ..     252     273 ..     251     282 .. 0.71
   7 ?   -3.2   0.0       7.5   1.1e+04       5      11 ..     322     328 ..     322     333 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 6
     Kelch_3 39 paRaghaata 48
                p R+gh++++
  EFC39866.1  9 PSRTGHSCVL 18
                68*****986 PP

  == domain 2  score: 19.6 bits;  conditional E-value: 5.6e-07
     Kelch_3  1 gdrlyifGGlgd.dgqdrlndvyvydldtntWa...eiaslppaRaghaata 48
                ++++y fGG    + + ++nd+ ++++++ +W+   ++  +p++  +h+a++
  EFC39866.1 26 NNCVYMFGGTLSdQKTFPSNDLIEINVENQEWKefeNSKASPGPLFHHCACL 77
                689********84559999**************55555999*********96 PP

  == domain 3  score: 16.4 bits;  conditional E-value: 5.5e-06
     Kelch_3   1 gdrlyifGGlgddgqdrl.ndvyvydldtntWa...eiaslppaRaghaatai 49 
                 ++++ ifGG+     ++l n v+++++ + +W+   e + + ++R gh+++++
  EFC39866.1  85 DNEMIIFGGKS--KKKHLqNKVWSFNFYRKEWKclsEGDKMVSPRFGHSGVVF 135
                 589********..555555**************6444499*********9975 PP

  == domain 4  score: 24.4 bits;  conditional E-value: 1.8e-08
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaei..aslppaRaghaat 47 
                 g++l++fGGl+     + n++ +++l + +W+ i  + + ++R++ha++
  EFC39866.1 136 GNTLFVFGGLDEKKKLCRNELIAFNLKSKQWKLIemSVSISGRCHHASV 184
                 89*********9999999**************887688899*****987 PP

  == domain 5  score: 7.7 bits;  conditional E-value: 0.0029
     Kelch_3   5 yifGGlgddgqdrlndvyvydldtn.......t 30 
                 y+fGG    g ++lnd+ ++ l+t        +
  EFC39866.1 193 YLFGGQS--GKNVLNDFVRIKLSTYdegaakcE 223
                 9******..*************99766444443 PP

  == domain 6  score: -2.8 bits;  conditional E-value: 5.6
     Kelch_3   3 rlyifGGlgddgqdrlndvyvydl 26 
                 ++y +GG++  + +   d  ++dl
  EFC39866.1 252 KFYSIGGYN--MKKDFLDCVSLDL 273
                 589999999..7666666666666 PP

  == domain 7  score: -3.2 bits;  conditional E-value: 7.5
     Kelch_3   5 yifGGlg 11 
                 ++fGGl 
  EFC39866.1 322 FVFGGLY 328
                 79***97 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.8   0.0   1.4e-05     0.021       3      35 ..       9      48 ..       9      54 .. 0.83
   2 !   17.8   0.0   1.6e-06    0.0025       2      35 ..      67     105 ..      66     110 .. 0.83
   3 !   14.3   0.0     2e-05      0.03       4      40 ..     126     162 ..     125     164 .. 0.80
   4 !   14.1   0.0   2.4e-05     0.036       6      33 ..     179     206 ..     176     209 .. 0.78
   5 ?    0.4   0.0      0.45   6.7e+02       4      24 ..     236     260 ..     235     267 .. 0.66

  Alignments for each domain:
  == domain 1  score: 14.8 bits;  conditional E-value: 1.4e-05
     Kelch_5  3 ppRaghcavtvs......ekiYvyGGkvg.rdgsvsddvy 35
                p+R+gh+ v ++      + +Y++GG  + +   +s+d+ 
  EFC39866.1  9 PSRTGHSCVLYNshhhknNCVYMFGGTLSdQKTFPSNDLI 48
                69*******99656654466********999999999986 PP

  == domain 2  score: 17.8 bits;  conditional E-value: 1.6e-06
     Kelch_5   2 PppRaghcavtv......sekiYvyGGkvgrdgsvsddvy 35 
                 P p+++hca+ +      +++++++GGk+   +++ ++v+
  EFC39866.1  67 PGPLFHHCACLHklenhdDNEMIIFGGKS-KKKHLQNKVW 105
                 99********88555554599********.4888888888 PP

  == domain 3  score: 14.3 bits;  conditional E-value: 2e-05
     Kelch_5   4 pRaghcavtvsekiYvyGGkvgrdgsvs.ddvyvLdlp 40 
                 pR+gh+ v+ ++ ++v+GG + + ++++ +++  ++l+
  EFC39866.1 126 PRFGHSGVVFGNTLFVFGGLD-EKKKLCrNELIAFNLK 162
                 9******************99.6777766666666665 PP

  == domain 4  score: 14.1 bits;  conditional E-value: 2.4e-05
     Kelch_5   6 aghcavtv..sekiYvyGGkvgrdgsvsdd 33 
                  +h++v +  s+ +Y++GG +g  ++v +d
  EFC39866.1 179 CHHASVLDpeSGDWYLFGGQSG--KNVLND 206
                 4677777755599********6..888888 PP

  == domain 5  score: 0.4 bits;  conditional E-value: 0.45
     Kelch_5   4 pRaghcavtvsek....iYvyGGkv 24 
                 +R+gh++v  +++     Y +GG++
  EFC39866.1 236 SRFGHSMVLEKFEsglkFYSIGGYN 260
                 799****987533333355566666 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   9.8e-07    0.0015       2      42 ..      11      59 ..      10      65 .. 0.86
   2 ?    3.3   0.0     0.073   1.1e+02      11      40 ..      85     114 ..      74     116 .. 0.79
   3 !   18.3   0.0   1.4e-06    0.0021       1      44 [.     126     170 ..     126     173 .. 0.89
   4 ?    1.8   0.0      0.22   3.3e+02      13      32 ..     191     209 ..     178     214 .. 0.66
   5 ?    2.4   0.0      0.14   2.1e+02       4      40 ..     239     280 ..     236     282 .. 0.59

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 9.8e-07
     Kelch_6  2 raghslvsvg......gkiYifGGytds..spylnkvwvydpetksWeq 42
                r+ghs+v+++      + +Y+fGG   +  + ++n+++ +++e+  W++
  EFC39866.1 11 RTGHSCVLYNshhhknNCVYMFGGTLSDqkTFPSNDLIEINVENQEWKE 59
                99********55555445*******7778******************87 PP

  == domain 2  score: 3.3 bits;  conditional E-value: 0.073
     Kelch_6  11 ggkiYifGGytdsspylnkvwvydpetksW 40 
                 ++   ifGG +     +nkvw +++  k W
  EFC39866.1  85 DNEMIIFGGKSKKKHLQNKVWSFNFYRKEW 114
                 5567899**99988899*******877777 PP

  == domain 3  score: 18.3 bits;  conditional E-value: 1.4e-06
     Kelch_6   1 praghslvsvggkiYifGGytds.spylnkvwvydpetksWeqlp 44 
                 pr ghs v+ g+++++fGG++       n ++ +++++k W+ ++
  EFC39866.1 126 PRFGHSGVVFGNTLFVFGGLDEKkKLCRNELIAFNLKSKQWKLIE 170
                 6889*****************9995555999**********9875 PP

  == domain 4  score: 1.8 bits;  conditional E-value: 0.22
     Kelch_6  13 kiYifGGytdsspylnkvwv 32 
                   Y+fGG+++  + ln++ +
  EFC39866.1 191 DWYLFGGQSG-KNVLNDFVR 209
                 5599999999.888888766 PP

  == domain 5  score: 2.4 bits;  conditional E-value: 0.14
     Kelch_6   4 ghslvs..vgg..kiYifGGytdsspylnkvwv.ydpetksW 40 
                 ghs+v+    +  k+Y +GGy+    +l++v + ++ ++k W
  EFC39866.1 239 GHSMVLekFESglKFYSIGGYNMKKDFLDCVSLdLNNISKGW 280
                 677777443333599******984444444444444556666 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   50.7   0.0   1.3e-16   1.9e-13       1     120 []     508     624 ..     508     624 .. 0.84

  Alignments for each domain:
  == domain 1  score: 50.7 bits;  conditional E-value: 1.3e-16
                 EEEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE....GHHHHCH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd....srssenl 95 
                 Kvvl+G++++GKt++ + +     + ++ +t+  +++  +++       +++v ++++++WDtaGq +++ l+pl + + +++++ +      + +e++
  EFC39866.1 508 KVVLIGNAAIGKTCFYQALRGIPLELDYIPTVFDNYSV-QCH-------SEDV-TFNIALWDTAGQADYDRLRPLSYPQTDIFLVGFCclseLSMKETI 597
                 9******************************9888755.342.......1233.5899**************************977644223345789 PP

                 HHHHHHHHHHCSSS..-EEEEEE-TTT CS
         Roc  96 keWlkelkkvagks..pvilvgnkiDl 120
                  +W ke++++++++  p+il+ +kiDl
  EFC39866.1 598 YKWKKEIETYMPDIklPIILMSTKIDL 624
                 9**********987558999*****95 PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0    0.0025       3.7       9      41 ..      24      59 ..      11      62 .. 0.91
   2 !    7.9   0.0    0.0016       2.3      11      43 ..      85     118 ..      83     119 .. 0.94
   3 !   21.6   0.0   7.8e-08   0.00012       1      40 [.     126     167 ..     126     170 .. 0.95
   4 ?   -3.0   0.0       3.9   5.9e+03      31      39 ..     184     192 ..     178     192 .. 0.67
   5 ?    4.3   0.0      0.02        30      15      31 ..     193     209 ..     193     214 .. 0.86
   6 ?    0.7   0.0      0.26     4e+02      13      29 ..     252     269 ..     249     278 .. 0.81

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.0025
                EETTEEEEEEEBCS...SSBEEEEEEEETTTTEEEE CS
     Kelch_1  9 vvggkiYviGGsdg...gnalssvevyDpetntWre 41
                  ++++Y +GG  +     +++++  +++e+++W e
  EFC39866.1 24 HKNNCVYMFGGTLSdqkTFPSNDLIEINVENQEWKE 59
                569*******************************86 PP

  == domain 2  score: 7.9 bits;  conditional E-value: 0.0016
                 TTEEEEEEEBCS.SSBEEEEEEEETTTTEEEEEC CS
     Kelch_1  11 ggkiYviGGsdg.gnalssvevyDpetntWrelp 43 
                 ++++ ++GG +      + v+ +++  ++W +l+
  EFC39866.1  85 DNEMIIFGGKSKkKHLQNKVWSFNFYRKEWKCLS 118
                 89****************************9987 PP

  == domain 3  score: 21.6 bits;  conditional E-value: 7.8e-08
                 BBBSEEEEEETTEEEEEEEBCS..SSBEEEEEEEETTTTEEE CS
     Kelch_1   1 aragagavvvggkiYviGGsdg..gnalssvevyDpetntWr 40 
                 +r g++ vv+g+ ++v+GG d+    + + + ++++++++W 
  EFC39866.1 126 PRFGHSGVVFGNTLFVFGGLDEkkKLCRNELIAFNLKSKQWK 167
                 799**************************************7 PP

  == domain 4  score: -3.0 bits;  conditional E-value: 3.9
                 EEETTTTEE CS
     Kelch_1  31 vyDpetntW 39 
                 v+Dpe++ W
  EFC39866.1 184 VLDPESGDW 192
                 678887777 PP

  == domain 5  score: 4.3 bits;  conditional E-value: 0.02
                 EEEEEBCSSSBEEEEEE CS
     Kelch_1  15 YviGGsdggnalssvev 31 
                 Y +GG++g n l+++ +
  EFC39866.1 193 YLFGGQSGKNVLNDFVR 209
                 99***********9866 PP

  == domain 6  score: 0.7 bits;  conditional E-value: 0.26
                 EEEEEEEBCS.SSBEEEE CS
     Kelch_1  13 kiYviGGsdg.gnalssv 29 
                 k Y iGG++    +l++v
  EFC39866.1 252 KFYSIGGYNMkKDFLDCV 269
                 6699*****986666665 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.8   0.0    0.0095        14       2      20 ..      11      35 ..      10      59 .. 0.76
   2 ?    5.3   0.1     0.014        21      10      46 ..      78     118 ..      69     121 .. 0.82
   3 !   13.0   0.0   5.1e-05     0.076       1      44 [.     126     168 ..     126     170 .. 0.94
   4 ?   -2.9   0.0       5.3   7.9e+03       3      19 ..     179     197 ..     177     207 .. 0.57
   5 !    6.7   0.1    0.0051       7.6       2      32 ..     237     273 ..     236     280 .. 0.76
   6 ?   -3.3   0.0         7     1e+04      15      23 ..     322     330 ..     322     338 .. 0.72
   7 ?   -2.6   0.0       4.2   6.3e+03       8      18 ..     574     584 ..     573     602 .. 0.84

  Alignments for each domain:
  == domain 1  score: 5.8 bits;  conditional E-value: 0.0095
     Kelch_2  2 rgghsssvp......ggkiyvvGGa 20
                r ghs++        ++++y++GG 
  EFC39866.1 11 RTGHSCVLYnshhhkNNCVYMFGGT 35
                789****888**************7 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.014
     Kelch_2  10 p......ggkiyvvGGahtdnpnlsssdvhvldlekhvWeevt 46 
                        ++ ++++GG   + + + +++v+ +++  ++W++++
  EFC39866.1  78 HklenhdDNEMIIFGGK--SKKKHLQNKVWSFNFYRKEWKCLS 118
                 466666688999****9..9********************987 PP

  == domain 3  score: 13.0 bits;  conditional E-value: 5.1e-05
     Kelch_2   1 rrgghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWee 44 
                 +r+ghs +v g+ ++v+GG  +  + l  + +  ++l++++W++
  EFC39866.1 126 PRFGHSGVVFGNTLFVFGGL-DEKKKLCRNELIAFNLKSKQWKL 168
                 799*****************.999999999************86 PP

  == domain 4  score: -2.9 bits;  conditional E-value: 5.3
     Kelch_2   3 gghsss.vp.ggkiyvvGG 19 
                 ++h+s+  p  g  y++GG
  EFC39866.1 179 CHHASVlDPeSGDWYLFGG 197
                 4555443223444555555 PP

  == domain 5  score: 6.7 bits;  conditional E-value: 0.0051
     Kelch_2   2 rgghsssvp....ggkiyvvGGa..htdnpnlsssdv 32 
                 r+ghs++      g k y++GG+    d  +++s d+
  EFC39866.1 237 RFGHSMVLEkfesGLKFYSIGGYnmKKDFLDCVSLDL 273
                 78999999999999*********55555555555554 PP

  == domain 6  score: -3.3 bits;  conditional E-value: 7
     Kelch_2  15 yvvGGahtd 23 
                 +v+GG ++ 
  EFC39866.1 322 FVFGGLYEN 330
                 89***9444 PP

  == domain 7  score: -2.6 bits;  conditional E-value: 4.2
     Kelch_2   8 svpggkiyvvG 18 
                 s+p+  i++vG
  EFC39866.1 574 SYPQTDIFLVG 584
                 78999999998 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.0   1.9   1.5e-07   0.00022       5      36 ..     362     393 ..     361     393 .. 0.96

  Alignments for each domain:
  == domain 1  score: 21.0 bits;  conditional E-value: 1.5e-07
                 HS-HHHHHHHHHTS-HHHHHHHCTT-HHHHHH CS
       F-box   5 rLPsevlrhILerLplsdllalrrVSkgwril 36 
                 +L +++ r IL++L+  dll l +V+k++ri+
  EFC39866.1 362 ELNDDIFRSILSFLSIPDLLKLELVCKRLRIC 393
                 699***************************98 PP

>> GTP_EFTU  Elongation factor Tu GTP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.0   1.7e-06    0.0026      65     191 ..     549     681 ..     507     683 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.7e-06
                 TTCSSEEEEEEEESSSGGGHHHHHHHHHT-SEEEEEEETTTB.STHHHHHHHHHHHHTTTE.....EEEEEESCGST...HHHHHHHHHHHHHHHHHHH CS
    GTP_EFTU  65 ketkkylinliDtPGHvdFskevirglrvlDgavlvvdaveG.vepqteevlrlalkegvp.....iivfiNKmDrl...kaelkeiveevkqklsrke 154
                 +e  +++i+l Dt G +d+ +    ++ ++D+ ++ +++ +   +  t   ++  ++  +p     ii++ +K+D      ++ k +v+e+k+ +s +e
  EFC39866.1 549 SEDVTFNIALWDTAGQADYDRLRPLSYPQTDIFLVGFCCLSElSMKETIYKWKKEIETYMPdiklpIILMSTKIDLRddpVQSRKLLVTEMKKPISYQE 647
                 45667889999************************999987755667766666555444333334499*******997777778888999999996666 PP

                 HHHHHHHHTTTTTEEEEEEBTTTTBTHHHHHHHHHHH CS
    GTP_EFTU 155 eklekygekgekevpvvfgSalkgegvktllealvel 191
                 ++l + +       + v +Sal++ g++ + e +++ 
  EFC39866.1 648 GELLARKLG---CATYVETSALTNAGMDRICELIIKT 681
                 666555444...579*****************99986 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.3   4.9e-06    0.0073       6      43 ..     365     403 ..     363     407 .. 0.79

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 4.9e-06
  F-box-like   6 dEiLlqIFsyLppsdLlrlalVCrrWrrvaldt.plLWr 43 
                 d+i   I+s+L+  dLl l lVC+r r + l+t  ++W+
  EFC39866.1 365 DDIFRSILSFLSIPDLLKLELVCKRLRICNLTTeDEFWK 403
                 577889*******************98765444345665 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.1   0.0   0.00034       0.5       3      29 ..     508     536 ..     506     548 .. 0.84
   2 ?    1.9   0.0      0.11   1.7e+02     115     141 ..     652     678 ..     611     680 .. 0.81

  Alignments for each domain:
  == domain 1  score: 10.1 bits;  conditional E-value: 0.00034
   PduV-EutP   3 killiGkvgsGKttLtqalkg..eelkYk 29 
                 k++liG+   GKt   qal+g   el Y 
  EFC39866.1 508 KVVLIGNAAIGKTCFYQALRGipLELDYI 536
                 89******************955666665 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.11
   PduV-EutP 115 LksaGaekifevsavekegieellkyl 141
                  ++ G+++  e+sa+++ g++++ + +
  EFC39866.1 652 ARKLGCATYVETSALTNAGMDRICELI 678
                 35789***************9998765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (700 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       537  (0.0299515); expected 358.6 (0.02)
Passed bias filter:                      384  (0.0214178); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 3801.97
//
Query:       EFC39867.1  [L=311]
Description: hypothetical protein NAEGRDRAFT_81173 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.7e-22   78.2   0.0    7.4e-22   77.6   0.0    1.3  1  CH        Calponin homology (CH) domain
    5.8e-10   38.6   6.1    1.1e-09   37.7   6.1    1.5  1  SHOCT     Short C-terminal domain
  ------ inclusion threshold ------
      0.034   14.0   2.1       0.18   11.7   0.4    2.6  2  DUF2847   Protein of unknown function (DUF2847)


Domain annotation for each model (and alignments):
>> CH  Calponin homology (CH) domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   77.6   0.0   1.2e-25   7.4e-22       3     106 ..      39     140 ..      37     143 .. 0.92

  Alignments for each domain:
  == domain 1  score: 77.6 bits;  conditional E-value: 1.2e-25
                 HHHHHHHHHHHHHTTSTTSSTTSCHHHHHTTSHHHHHHHHHHSTTTSSGGGSTTTHHHHHHHHHHHHHHHHHHTTCHTTSS.-HHHHHTTSHH.HHHHH CS
          CH   3 qkkellrWinshleeagpkvkvedfeedlrDGvlLckLlnklapglvdkkklnksefkkleNinlaldvaekklgvpkvli.eaedlvegknk.svltl 99 
                  ++e+ +Wi+s+++e+  +   +df+e+l+DG+lLckL+nk++pg+++k + +k +f ++eNi ++l++a+ +lg++k +   ++dl+e kn  +v++ 
  EFC39867.1  39 KEREVQQWIESVVGEKFAS---NDFQESLKDGHLLCKLINKIKPGSIPKINQSKLPFMQMENIGYFLKAAA-DLGLQKHDAfMTVDLYESKNIpQVIQS 133
                 688999*******997665...79*************************999888*************888.*********************9***99 PP

                 HHHHHHH CS
          CH 100 laqLfra 106
                 l  + ++
  EFC39867.1 134 LFIFGSV 140
                 9887765 PP

>> SHOCT  Short C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.7   6.1   1.9e-13   1.1e-09       1      28 []     282     309 ..     282     309 .. 0.97

  Alignments for each domain:
  == domain 1  score: 37.7 bits;  conditional E-value: 1.9e-13
       SHOCT   1 daLekLkeLyarGeIteEEFeakKakLL 28 
                 ++LekL++L+++G++teEEF++kK+++L
  EFC39867.1 282 EELEKLASLRDKGILTEEEFQQKKRQIL 309
                 69*************************8 PP

>> DUF2847  Protein of unknown function (DUF2847)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.4     3e-05      0.18       5      71 ..     165     231 ..     161     234 .. 0.92
   2 ?    5.4   0.6    0.0029        17      22      70 ..     214     262 ..     205     273 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 3e-05
     DUF2847   5 teeqleeileeskekpvlifKhstrcsiSaealkelekeleeeeeevkvylldviesrevSneiaek 71 
                 teeql+++ +e  ++ ++ +Kh+t  siS+e++k+  +  ++ +++++++ ++  + r++S e+ ++
  EFC39867.1 165 TEEQLRKANAEVGQQYMASIKHDTGRSISREVVKTRDTGDASVTSQLSTASIKHDTGRSISREVVKT 231
                 689*******************************999999998889***************999765 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.0029
     DUF2847  22 lifKhstrcsiSaealkelekeleeeeeevkvylldviesrevSneiae 70 
                 + +Kh+t  siS+e++k+ ++  ++ +++ +   +   ++r++Sne+ +
  EFC39867.1 214 ASIKHDTGRSISREVVKTSSTGDKRFTSQQNEKSISHGQDRSISNEVVK 262
                 568**************999998888888899999999*******9965 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (311 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       926  (0.0516482); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.52u 0.27s 00:00:00.79 Elapsed: 00:00:00.44
# Mc/sec: 2102.00
//
Query:       EFC39868.1  [L=857]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (857 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1242  (0.0692732); expected 358.6 (0.02)
Passed bias filter:                      413  (0.0230353); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.81u 0.33s 00:00:01.14 Elapsed: 00:00:00.55
# Mc/sec: 4697.22
//
Query:       EFC39869.1  [L=376]
Description: ran family small GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      7e-30  103.8   0.0    1.2e-29  103.0   0.0    1.3  1  Ras              Ras family
    2.6e-21   76.1   0.0      5e-21   75.1   0.0    1.5  1  Roc              Ras of Complex, Roc, domain of DAPkinase
    1.6e-07   30.9   0.0      3e-07   30.1   0.0    1.4  1  Arf              ADP-ribosylation factor family
    0.00025   20.5   0.0    0.00057   19.3   0.0    1.6  1  Gtr1_RagA        Gtr1/RagA G protein conserved region
    0.00027   21.0   0.0    0.00049   20.2   0.0    1.4  1  MMR_HSR1         50S ribosome-binding GTPase
    0.00082   19.1   0.1     0.0024   17.6   0.0    1.8  2  PduV-EutP        Ethanolamine utilisation - propanediol utili
     0.0039   16.9   0.1     0.0065   16.2   0.1    1.5  1  AAA_24           AAA domain
  ------ inclusion threshold ------
      0.014   15.3   0.1      0.033   14.1   0.1    1.6  1  F-box-like       F-box-like
      0.019   14.7   0.0      0.058   13.2   0.0    1.7  1  ATP_bind_1       Conserved hypothetical ATP binding protein
      0.028   14.1   0.0      0.045   13.5   0.0    1.3  1  Sigma54_activat  Sigma-54 interaction domain
      0.038   14.3   0.0       0.14   12.4   0.0    2.0  2  AAA_22           AAA domain
      0.056   13.2   0.0       0.13   12.0   0.0    1.6  1  RuvB_N           Holliday junction DNA helicase RuvB P-loop d
      0.086   12.2   0.0       0.21   11.0   0.0    1.6  1  TniB             Bacterial TniB protein
       0.18   12.2   0.0       0.43   10.9   0.0    1.6  2  AAA_16           AAA ATPase domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  103.0   0.0   9.2e-33   1.2e-29       1     151 [.     197     346 ..     197     354 .. 0.92

  Alignments for each domain:
  == domain 1  score: 103.0 bits;  conditional E-value: 9.2e-33
                 EEEEEESTTSSHHHHHHHHHHSSCSSS.CTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHH CS
         Ras   1 KlvlvGdsavGKtslllrfvkdkFkee.yesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeik 98 
                 K++++G+++vGKt++  +  +   +++   +Tig++  + ++++ g e+++++wDT Gqe+f  lr++ y +++++++++d+tsr s++++ +w+++ik
  EFC39869.1 197 KILIIGNGGVGKTTFCRSMQDLPLNDNrNLPTIGCEINSYRLKIAGLEANINLWDTVGQEKFGFLRDTLYVNTSVCIICFDLTSRYSYKSILNWFRDIK 295
                 89*************9999998887651579******************************************************************** PP

                 HHSTTTSEEEEEEETTTGGGG-SS-HHHHHHHHHHHTSEEEEEBTTTTCTHHH CS
         Ras  99 rvaeenvpivLvGnKvDleekravsteegeelakelglkfletSAktnenvee 151
                 rv +e ++++ vG+K Dl+++ +v+ ++   +  ++ ++++  S  ++ n + 
  EFC39869.1 296 RVEPE-CEVIFVGTKLDLTDNLKVTPKQIT-FPINKYCPYIGLSSLQQINNRA 346
                 ****5.******************999976.7777889999999999888665 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   75.1   0.0   3.9e-24     5e-21       1     120 []     197     312 ..     197     312 .. 0.89

  Alignments for each domain:
  == domain 1  score: 75.1 bits;  conditional E-value: 3.9e-24
                 EEEEESSTTSSHHHHHHCHCT-CCC-E.EETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE..GH.HHHCH CS
         Roc   1 KvvlvGdsgvGKtsllkrfvedkfsek.ekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd..sr.ssenl 95 
                 K++++G++gvGKt++++++++   +++ + +tig+++ + ++ ki g+       + ++n+WDt Gqe+f  l++  + + +++i+++d  sr s++++
  EFC39869.1 197 KILIIGNGGVGKTTFCRSMQDLPLNDNrNLPTIGCEINSYRL-KIAGL-------EANINLWDTVGQEKFGFLRDTLYVNTSVCIICFDltSRySYKSI 287
                 9********************9998761569********998.78886.......3579******************************6533355889 PP

                 HHHHHHHHHHCSSS-EEEEEE-TTT CS
         Roc  96 keWlkelkkvagkspvilvgnkiDl 120
                  +W++++k+v +++ vi+vg+k+Dl
  EFC39869.1 288 LNWFRDIKRVEPECEVIFVGTKLDL 312
                 9**********************95 PP

>> Arf  ADP-ribosylation factor family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.1   0.0   2.3e-10     3e-07      11     133 ..     191     318 ..     182     334 .. 0.78

  Alignments for each domain:
  == domain 1  score: 30.1 bits;  conditional E-value: 2.3e-10
                 .TTEE.EEEEEESTTSSHHHHHHHHHHSSCEE..CSSSSSEEEEE..EEET..TEEEEEEEE-SSGGGGGGGGGGCTTESEEEEEEETT-CTTHHHHHH CS
         Arf  11 kkkel.rilllGLDnaGKtTilkklkleelvt..tvPTigfnvee..leik..nlkftvwDvGGqeklRplWknYfektdavifvvDsadreRleeake 102
                 ++ e+ +il++G  + GKtT    +++  l++    PTig ++++  l+i   + ++++wD  Gqek   l ++ + +t + i + D + r   ++  +
  EFC39869.1 191 RNTEMkKILIIGNGGVGKTTFCRSMQDLPLNDnrNLPTIGCEINSyrLKIAglEANINLWDTVGQEKFGFLRDTLYVNTSVCIICFDLTSRYSYKSILN 289
                 4555527***************99999877654489****9887622555522567999****************************998877666666 PP

                 HHHHHCTSGCCT.TSEEEEEEE-TTSTTSS-H CS
         Arf 103 eLkalleeeelk.evallvlaNKqDlpealse 133
                  ++ +    +++ e+ ++ ++ K Dl++ l+ 
  EFC39869.1 290 WFRDIK---RVEpECEVIFVGTKLDLTDNLKV 318
                 665554...44447888999999999988765 PP

>> Gtr1_RagA  Gtr1/RagA G protein conserved region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.0   4.5e-07   0.00057       1     124 [.     197     313 ..     197     324 .. 0.78

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 4.5e-07
   Gtr1_RagA   1 kvLLmGksgsGKtsmrsiiFdnylardtlrl.gatidveksevrflg.nltlnlwDcgGqeafveeylssqkeeifrnvgvliyVfDvesr.eleedle 96 
                 k+L++G++g GKt+ ++ + + +  +d ++l ++  +++  ++++ g + ++nlwD  Gqe+f        +++++ n +v i  fD +sr +++    
  EFC39869.1 197 KILIIGNGGVGKTTFCRSM-QDLPLNDNRNLpTIGCEINSYRLKIAGlEANINLWDTVGQEKFG-----FLRDTLYVNTSVCIICFDLTSRySYK---- 285
                 89************99886.6678888888834566777777777773579*********9875.....5689****************773344.... PP

   Gtr1_RagA  97 tlkeilealrqyspeakvfvlihKmDli 124
                 ++ + ++ +++++pe +v     K+Dl 
  EFC39869.1 286 SILNWFRDIKRVEPECEVIFVGTKLDLT 313
                 4455667788889999888877888876 PP

>> MMR_HSR1  50S ribosome-binding GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.2   0.0   3.8e-07   0.00049       1      93 [.     197     287 ..     197     309 .. 0.77

  Alignments for each domain:
  == domain 1  score: 20.2 bits;  conditional E-value: 3.8e-07
                 EEEEEESTTSSHHHHHHHHHTS.TEEESSSTTSSSSEEEEEEEETT..EEEEEEECGGCSSHHHHHHHHHHHHHHHHCTSEEEEEEETTTT.CSHHH CS
    MMR_HSR1   1 evaivGrpNvGKStLinaltge.kaivsdkpgtTrdinegrvklkg..keielvDtpGliegaseekglgkaflaleeadlillvvdasee.klkpl 93 
                 +++i+G+  vGK+t+ +++ +       + p    +in +r+k+ g   +i+l+Dt+G  e    + g+ ++ l   ++++ ++++d++++ ++k +
  EFC39869.1 197 KILIIGNGGVGKTTFCRSMQDLpLNDNRNLPTIGCEINSYRLKIAGleANINLWDTVG-QE----KFGFLRDTLY-VNTSVCIICFDLTSRySYKSI 287
                 589****************99867899999*************8876789********.55....6688888885.556899999997733233333 PP

>> PduV-EutP  Ethanolamine utilisation - propanediol utilisation
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.6   0.0   1.9e-06    0.0024       1      27 [.     195     221 ..     195     226 .. 0.92
   2 ?   -3.0   0.0       4.3   5.5e+03      91     103 ..     302     314 ..     280     330 .. 0.71

  Alignments for each domain:
  == domain 1  score: 17.6 bits;  conditional E-value: 1.9e-06
   PduV-EutP   1 mkkilliGkvgsGKttLtqalkgeelk 27 
                 mkkil+iG+ g+GKtt ++++++  l+
  EFC39869.1 195 MKKILIIGNGGVGKTTFCRSMQDLPLN 221
                 9*********************98875 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.3
   PduV-EutP  91 eviGiitkidlae 103
                 evi + tk+dl++
  EFC39869.1 302 EVIFVGTKLDLTD 314
                 5666777777762 PP

>> AAA_24  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.2   0.1   5.1e-06    0.0065       3      23 ..     196     216 ..     194     308 .. 0.89

  Alignments for each domain:
  == domain 1  score: 16.2 bits;  conditional E-value: 5.1e-06
      AAA_24   3 lkiliyGpsgiGKTtlakelg 23 
                 +kili+G  g+GKTt++++++
  EFC39869.1 196 KKILIIGNGGVGKTTFCRSMQ 216
                 79*****************93 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.1   0.1   2.5e-05     0.033       2      33 ..      13      46 ..      12      54 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.1 bits;  conditional E-value: 2.5e-05
  F-box-like  2 srLPdEi.LlqIFsyLp.psdLlrlalVCrrWrr 33
                 +LP Ei L qI +yL+ +  + +l +VC+ +r 
  EFC39869.1 13 INLPKEIwLYQICEYLDiLDMIFSLGRVCKAFRY 46
                58****83559*****83557999*******986 PP

>> ATP_bind_1  Conserved hypothetical ATP binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   4.5e-05     0.058       1      27 [.     200     226 ..     200     240 .. 0.85

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 4.5e-05
  ATP_bind_1   1 vvGpaGsGKttfvgalseilelrgrsv 27 
                 ++G  G+GKttf+++++++  + +r++
  EFC39869.1 200 IIGNGGVGKTTFCRSMQDLPLNDNRNL 226
                 79***************9887777766 PP

>> Sigma54_activat  Sigma-54 interaction domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0   3.5e-05     0.045      10      58 ..     183     231 ..     173     243 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 3.5e-05
                      HHHHHHHHHCTSSS-EEEECSTTSSHHHHHHHHHHHSTTTTS-EEEEET CS
  Sigma54_activat  10 elleqikkvaktdlsvlitGesGtGKellaraiheaskrkekpfvavnc 58 
                      +l+e+ ++  +   ++li G+ G+GK+++ r++ +   ++++++ ++ c
       EFC39869.1 183 QLVESSSARNTEMKKILIIGNGGVGKTTFCRSMQDLPLNDNRNLPTIGC 231
                      445555555555689*******************988888877777777 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   0.00011      0.14       8      31 ..     198     221 ..     192     300 .. 0.80
   2 ?   -1.9   0.0       2.9   3.7e+03     107     134 ..     286     313 ..     276     316 .. 0.71

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00011
      AAA_22   8 lvvtGesGtGKTtllrrlleqlde 31 
                 ++++G  G+GKTt +r +++   +
  EFC39869.1 198 ILIIGNGGVGKTTFCRSMQDLPLN 221
                 79***************9998754 PP

  == domain 2  score: -1.9 bits;  conditional E-value: 2.9
      AAA_22 107 ealeeLrsllnlsrkgvqliLvGtp.elr 134
                  +l+++r++    +  + +i+vGt  +l 
  EFC39869.1 286 SILNWFRDIKR-VEPECEVIFVGTKlDLT 313
                 56777777766.66778888999877765 PP

>> RuvB_N  Holliday junction DNA helicase RuvB P-loop domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.0   0.0   9.9e-05      0.13      21      51 ..     183     213 ..     161     226 .. 0.86

  Alignments for each domain:
  == domain 1  score: 12.0 bits;  conditional E-value: 9.9e-05
      RuvB_N  21 ifieaakkreealdhvllyGpPGlGkttlak 51 
                  ++e++ +r++++  +l++G  G+Gktt+++
  EFC39869.1 183 QLVESSSARNTEMKKILIIGNGGVGKTTFCR 213
                 468999**********************976 PP

>> TniB  Bacterial TniB protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   0.0   0.00016      0.21      29      58 ..     189     218 ..     169     230 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 0.00016
        TniB  29 ypkrkrmpnlllvGdsnnGKtmivekFarl 58 
                  +++++m+++l++G+  +GKt+ +++ ++l
  EFC39869.1 189 SARNTEMKKILIIGNGGVGKTTFCRSMQDL 218
                 36799******************9988766 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.0       7.5   9.6e+03      76      99 ..      98     120 ..      73     147 .. 0.49
   2 ?   10.9   0.0   0.00034      0.43      24      46 ..     193     217 ..     182     238 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 7.5
      AAA_16  76 lareellrqlldeaesaeleawre 99 
                 l++e+++++ ++ + s e++ +++
  EFC39869.1  98 LTNEGIFEKKDTSHVS-EQSNAQQ 120
                 4444444444444444.2222222 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 0.00034
      AAA_16  24 p..elvllsGesGvGKsslvrellr 46 
                 +    +l++G+ GvGK++  r+ ++
  EFC39869.1 193 TemKKILIIGNGGVGKTTFCRSMQD 217
                 334779************9998874 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (376 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       815  (0.0454571); expected 358.6 (0.02)
Passed bias filter:                      527  (0.0293937); expected 358.6 (0.02)
Passed Vit filter:                        80  (0.00446204); expected 17.9 (0.001)
Passed Fwd filter:                        14  (0.000780858); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              14  [number of targets reported over threshold]
# CPU time: 0.62u 0.29s 00:00:00.90 Elapsed: 00:00:00.47
# Mc/sec: 2387.79
//
Query:       EFC39870.1  [L=308]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    1.8e-14   53.8   0.0    2.5e-12   46.7   0.0    2.1  2  SBP_bac_3  Bacterial extracellular solute-binding proteins, f


Domain annotation for each model (and alignments):
>> SBP_bac_3  Bacterial extracellular solute-binding proteins, family 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.1   0.0   0.00076        14     186     219 ..      18      51 ..       2      57 .. 0.84
   2 !   46.7   0.0   1.4e-16   2.5e-12      46     183 ..     130     265 ..     117     278 .. 0.85

  Alignments for each domain:
  == domain 1  score: 5.1 bits;  conditional E-value: 0.00076
                 EEEEEEETTTHHHHHHHHHHHHHHHHTTHHHHHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 186 eyaiavrkgdseLrkainkalaelkadgtlakis 219
                 +++i++   ++++ +a+++a++++++d +++k +
  EFC39870.1  18 NVGIFAITVSQDFTNAFDAAVQAMITDSEWNKFY 51 
                 667777788899*******************988 PP

  == domain 2  score: 46.7 bits;  conditional E-value: 1.4e-16
                 SGGGHHHHHHTTSSSEEESSEB--HHHHTTEEEESESEEEEEEEEEEETTSHGTCCHSSCGCGTTS..EEEEETTSHHHHHHHHHHHCTSEEEEESSHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3  46 swdelipalksgkvDiaiaaititpeReekvdFsqpyfsagqvllvrkkdaskissiksladLkgk..kvgvqagstaeellkeelkkgaeivefdtle 142
                  +d++ +a+++g +D++ a+i +t+eR   + +  p+ s + + +  k d++   si+++++L+ +  +vg+  g++ ++++k +l+  a+ v++  ++
  EFC39870.1 130 FFDTMKNAVNNGDCDMITANILVTAERSSSIHYQCPFGSGSNGWIRTKRDPQ--LSITDISQLNKTgiMVGAYEGTAFATYVKTNLP-AATFVPYSGIN 225
                 689999***************************************9985543..678888899544449**************9887.99********* PP

                 HHHHHHHTTSSSEEEEEHHHHHHHHHHCCGCCEEEEECGGC CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
   SBP_bac_3 143 ealqaLkngrvdavvadspvlaylvkknpdkkvvlveepls 183
                   + a+ +g+v a+++d +  +++++ +  +k+   +++ +
  EFC39870.1 226 LQYDAVLDGSVHAIIGDAIQYYNWANVQMSGKCNC-TVKTY 265
                 ********************999998877666655.55555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (308 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       759  (0.0423336); expected 358.6 (0.02)
Passed bias filter:                      433  (0.0241508); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.32s 00:00:00.90 Elapsed: 00:00:00.53
# Mc/sec: 1751.01
//
Query:       EFC39871.1  [L=407]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.3e-28   98.8   0.9    4.3e-25   88.6   0.9    3.2  1  Pkinase         Protein kinase domain
    8.4e-17   61.3   0.1    4.5e-14   52.4   0.0    3.1  3  Pkinase_Tyr     Protein tyrosine kinase
    9.9e-09   34.5   0.0    1.5e-08   33.9   0.0    1.3  1  Pkinase_fungal  Fungal protein kinase
     0.0021   17.5   0.1     0.0057   16.0   0.0    1.6  2  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.011   15.2   0.0      0.022   14.3   0.0    1.4  1  YrbL-PhoP_reg   PhoP regulatory network protein YrbL
      0.022   14.1   0.0       0.04   13.2   0.0    1.4  1  Kinase-like     Kinase-like
      0.032   14.2   0.0      0.081   12.8   0.0    1.6  2  APH             Phosphotransferase enzyme family
      0.065   13.7   0.1       0.12   12.9   0.1    1.5  1  TEX33           Testis-expressed sequence 33 protein family


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   88.6   0.9   1.9e-28   4.3e-25      45     204 ..      36     202 ..      11     232 .. 0.76

  Alignments for each domain:
  == domain 1  score: 88.6 bits;  conditional E-value: 1.9e-28
                 HHHHHHHHHHHSCTTB--EEEEE..EESSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTE....E CS
     Pkinase  45 vlrEikilkklkhpnivrlyevf..eekdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekge....l 137
                 +++  + +kk++hp ++ + + f  e ++ l++v  y e g    +l+  g+++  +  +i+ ++ ++l+ylHs++++HrD+Kp+NiL+++k++    +
  EFC39871.1  36 IAKDGEAIKKFDHPLLLSIERLFwyEAEKLLLIVSPYYELG----HLR--GQFTLGQYWSILCNLTNALKYLHSQQVVHRDIKPANILVEKKDKfevkV 128
                 44455678899999999887754115577778999999977....553..67999***********************************766679777 PP

                 EE-SGTTSEESSSSCSBCTTTSCGGGS-HHHH.........TTSCBSHHHHHHHHHHHHHHHHHSS-STTTSSHHH CS
     Pkinase 138 KitDFGlakelessskltsfvgtseYlAPEvl.........keneyskkvDvWslGvilyelltgkppfsgekgke 204
                  ++DFGlak ++s+s     vgt +++APE++         +++   +k+D++slG ++  l+ +  p   e +k 
  EFC39871.1 129 VLADFGLAKSFDSCS--AGSVGTTYFVAPELMkgydgehsaRRRVANEKSDIFSLGKTISVLILNDKPEDLEFKKG 202
                 89***********99..899************999887765556679*************9999998876333333 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.0     0.042        94       2      17 ..      12      27 ..      11      32 .. 0.87
   2 !   52.4   0.0     2e-17   4.5e-14      47     194 ..      35     184 ..      27     195 .. 0.83
   3 ?    2.9   0.0     0.025        57     232     257 ..     203     228 ..     195     230 .. 0.89

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.042
                 EEEEEEEEESSEEEEE CS
  Pkinase_Tyr  2 elgkklGeGafGkVve 17
                 +l k++GeGa+G+V++
   EFC39871.1 12 SLVKRIGEGAYGSVYR 27
                 6789**********97 PP

  == domain 2  score: 52.4 bits;  conditional E-value: 2e-17
                  HHHHHHHHHHTS-BTTB--EEEEEE..SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST-SGGGEEEEE.... CS
  Pkinase_Tyr  47 elleeakimkklkhpnivkllgvct..keepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdlaarNvLlse.... 138
                  ++ ++ + +kk++hp ++++  +     e+ lliv  y + G+L+         ++tl +  s+  ++ ++++yL+s+++vHrd+   N+L+++    
   EFC39871.1  35 KIAKDGEAIKKFDHPLLLSIERLFWyeAEKLLLIVSPYYELGHLR--------GQFTLGQYWSILCNLTNALKYLHSQQVVHRDIKPANILVEKkdkf 124
                  66778889999******99998887645555899999****9874........458999**********************************95544 PP

                  TTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS-HHHHHHSE.........EEHHHHHHHHHHH CS
  Pkinase_Tyr 139 nkvvkisDfGLardiekddeyvkkeeaklpvkWmapEslkekk.........ftsksDvWsfGvl 194
                  + +v ++DfGLa++       + + ++     ++apE +k             ++ksD++s G +
   EFC39871.1 125 EVKVVLADFGLAKSF-----DSCSAGSVGTTYFVAPELMKGYDgehsarrrvANEKSDIFSLGKT 184
                  446778********9.....4556677778889999999987777888888899*******9965 PP

  == domain 3  score: 2.9 bits;  conditional E-value: 0.025
                  HHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 232 eelyelmkkcweedpeeRptfselve 257
                  ++l+el+++ ++++pe+Rp+  e+++
   EFC39871.1 203 NSLTELLNRMMKYKPENRPSTDEIIS 228
                  67899***************999975 PP

>> Pkinase_fungal  Fungal protein kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.9   0.0   6.7e-12   1.5e-08     317     395 ..      96     195 ..      82     256 .. 0.79

  Alignments for each domain:
  == domain 1  score: 33.9 bits;  conditional E-value: 6.7e-12
  Pkinase_fungal 317 kghrsLflkagiLHrDiSenNilitdskkegerkglLiDLDlakelsddssesgarertGTleFmaievlkgee..Hsyr............... 394
                     ++++ L+  ++++HrDi   Nil+  +k++ e k +L+D+ lak+ +    ++g    +GT++F+a e++kg +  Hs r               
      EFC39871.1  96 NALKYLH-SQQVVHRDIKPANILVE-KKDKFEVKVVLADFGLAKSFDSC--SAG---SVGTTYFVAPELMKGYDgeHSARrrvaneksdifslgk 183
                     6788999.99************988.777789***************53..444...68************94445*998555555555555555 PP

  Pkinase_fungal 395 ...........h 395
                                 
      EFC39871.1 184 tisvlilndkpE 195
                     555555555553 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.0   0.0   2.6e-06    0.0057     128     166 ..      95     133 ..      88     139 .. 0.88
   2 ?   -2.4   0.0       1.1   2.5e+03     146     173 ..     319     345 ..     315     355 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.0 bits;  conditional E-value: 2.6e-06
         Kdo 128 grliaklhragvnHadlyaknillqqeeeeeaeiwliDl 166
                   + + lh+ +v H+d+ + nil++++++ e +++l D+
  EFC39871.1  95 TNALKYLHSQQVVHRDIKPANILVEKKDKFEVKVVLADF 133
                 567789*********************999999999999 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.1
         Kdo 146 aknillqqeeeeeaeiwliDldkarlrl 173
                 +  i+l+  +  +++  liD   +  ++
  EFC39871.1 319 IESIYLRIYN-TKFNTGLIDVTNCLSKS 345
                 6779999986.999999***99888776 PP

>> YrbL-PhoP_reg  PhoP regulatory network protein YrbL
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.3   0.0   9.8e-06     0.022     128     166 ..      94     132 ..      88     142 .. 0.90

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 9.8e-06
  YrbL-PhoP_reg 128 LdefleelldnhivtndlsakNivvkknsegeeelvlvD 166
                    L + l++l  +++v +d++++Ni+v+k+++ e ++vl D
     EFC39871.1  94 LTNALKYLHSQQVVHRDIKPANILVEKKDKFEVKVVLAD 132
                    677789**************************9999998 PP

>> Kinase-like  Kinase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.2   0.0   1.8e-05      0.04     153     256 ..      94     201 ..      87     220 .. 0.75

  Alignments for each domain:
  == domain 1  score: 13.2 bits;  conditional E-value: 1.8e-05
  Kinase-like 153 lirlaanLqakglvhgkftvdnllldekgg....lmlggftaLvragtkvvlsevekg.faPpEllgsrggytrknktkmthkldaWqlGlviyriwc 245
                  l +   +L+++++vh ++++ n+l ++k +    ++l +f+ L +  ++  + +v  + f  pEl+    g +  ++     k d   lG +i  +  
   EFC39871.1  94 LTNALKYLHSQQVVHRDIKPANILVEKKDKfevkVVLADFG-LAKSFDSCSAGSVGTTyFVAPELMKGYDGEHSARRRVANEKSDIFSLGKTISVLIL 190
                  5677789******************9865411115667775.88888888887777652578888877666556677777888999999999888877 PP

  Kinase-like 246 lklPltlatee 256
                   + P +l  ++
   EFC39871.1 191 NDKPEDLEFKK 201
                  77777776655 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.1   0.0       1.4     3e+03       2      31 ..      14      40 ..      14      52 .. 0.80
   2 ?   12.8   0.0   3.6e-05     0.081     163     190 ..     101     129 ..      55     138 .. 0.76

  Alignments for each domain:
  == domain 1  score: -2.1 bits;  conditional E-value: 1.4
                EEEE--.SSCEEEEEEETT--EEEEEE-TT CS
         APH  2 vrelsggasnrtylvttpagryvlrrnppa 31
                v++++ ga+  +y+++ ++   vl+++ ++
  EFC39871.1 14 VKRIGEGAYGSVYRIGKDK---VLKIAKDG 40
                578999**********965...88888877 PP

  == domain 2  score: 12.8 bits;  conditional E-value: 3.6e-05
                 SS-EEEE-SS-SGGGEEEC...TTEEEEE CS
         APH 163 elptvllHgDlhpgNllvd.pddgrvtGv 190
                   +++++H+D++p N+lv+ +d+ +v+ v
  EFC39871.1 101 LHSQQVVHRDIKPANILVEkKDKFEVKVV 129
                 4589***************7666666444 PP

>> TEX33  Testis-expressed sequence 33 protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.9   0.1   5.4e-05      0.12      47      97 ..     250     302 ..     194     310 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 5.4e-05
       TEX33  47 lpplkssstvssykd..LsdslrsdvlqGapqetkSlmkasyTkevieksvrd 97 
                  + +++ +++s y++  Lsd l + ++ G + + +S +k syT ++++  v +
  EFC39871.1 250 DNDIEIFDEMSFYTEssLSDGLLKMLISGESSQSQSAVKHSYTFDLHDDGVVN 302
                 44555556677775433999999999*********************977655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (407 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       697  (0.0388756); expected 358.6 (0.02)
Passed bias filter:                      366  (0.0204139); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.65u 0.32s 00:00:00.97 Elapsed: 00:00:00.53
# Mc/sec: 2303.01
//
Query:       EFC39872.1  [L=559]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.4e-91  292.9  29.7    1.1e-05   25.0   0.0   18.3 18  LRR_6       Leucine Rich repeat
    4.4e-51  170.5  17.5    8.5e-08   31.9   1.0    7.9  8  LRR_8       Leucine rich repeat
    7.2e-45  150.2  27.7    1.2e-05   25.6   0.9   10.8 14  LRR_4       Leucine Rich repeats (2 copies)
    1.2e-25   86.1   2.3        3.6    8.5   0.0   15.2 16  LRR_1       Leucine Rich Repeat
    6.6e-10   38.8  11.1      0.055   13.0   0.7    5.6  6  LRR_9       Leucine-rich repeat
    5.1e-09   36.2   2.1        2.9    7.7   0.0    7.9  9  DUF4347     Domain of unknown function (DUF4347)
    0.00066   19.9  16.1        8.7    6.7   0.1    8.1  8  DUF424      Protein of unknown function (DUF424)
  ------ inclusion threshold ------
      0.018   14.9  23.3      0.059   13.2   3.1    3.6  3  Beta_helix  Right handed beta helix region
       0.29   11.1  20.5        9.6    6.3   0.0    8.8 12  ApoB100_C   Apolipoprotein B100 C terminal
       0.83   10.6   4.1         15    6.6   0.1    4.4  6  bZIP_C      Basic leucine-zipper C terminal


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.0   7.9e-06     0.014       5      23 ..     125     143 ..     122     144 .. 0.91
   2 !    8.8   0.1   0.00099       1.8       5      24 .]     149     168 ..     146     168 .. 0.91
   3 !   23.8   0.1   1.5e-08   2.8e-05       5      24 .]     173     192 ..     170     192 .. 0.92
   4 !   10.7   0.0   0.00024      0.44       5      24 .]     197     216 ..     194     216 .. 0.92
   5 !   15.1   0.0   9.7e-06     0.017       5      24 .]     221     240 ..     218     240 .. 0.92
   6 !   18.3   0.1   8.9e-07    0.0016       4      23 ..     244     263 ..     242     264 .. 0.89
   7 !    9.2   0.1   0.00078       1.4       5      24 .]     269     288 ..     266     288 .. 0.91
   8 !   14.5   0.0   1.5e-05     0.027       5      23 ..     293     311 ..     290     312 .. 0.91
   9 !   18.6   0.0   7.2e-07    0.0013       5      24 .]     317     336 ..     314     336 .. 0.94
  10 !   13.0   0.0   4.5e-05     0.081       5      23 ..     341     359 ..     338     360 .. 0.89
  11 !   17.6   0.0   1.5e-06    0.0027       5      23 ..     365     383 ..     362     384 .. 0.91
  12 !   16.2   0.0   4.2e-06    0.0076       5      24 .]     389     408 ..     386     408 .. 0.94
  13 !   14.7   0.0   1.3e-05     0.023       5      23 ..     413     431 ..     410     432 .. 0.90
  14 !   25.0   0.0   6.3e-09   1.1e-05       5      24 .]     437     456 ..     434     456 .. 0.94
  15 !   15.3   0.0   8.6e-06     0.015       5      23 ..     461     479 ..     458     480 .. 0.89
  16 !   12.1   0.0   9.2e-05      0.17       5      24 .]     485     504 ..     482     504 .. 0.89
  17 !   24.9   0.0   6.9e-09   1.2e-05       5      24 .]     509     528 ..     506     528 .. 0.93
  18 !   21.5   0.1   8.5e-08   0.00015       5      23 ..     533     551 ..     530     552 .. 0.93

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 7.9e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L ++ N IgDeG++ +
  EFC39872.1 125 LTSLGIAENRIGDEGVKFI 143
                 9***************977 PP

  == domain 2  score: 8.8 bits;  conditional E-value: 0.00099
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt Ld+ +N+Ig eGa++++
  EFC39872.1 149 LTLLDICCNEIGVEGATSIS 168
                 889*************9986 PP

  == domain 3  score: 23.8 bits;  conditional E-value: 1.5e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++sgN IgDeGa+ ++
  EFC39872.1 173 LTSLNISGNRIGDEGAKLIS 192
                 9****************985 PP

  == domain 4  score: 10.7 bits;  conditional E-value: 0.00024
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L++++N I  eGa++++
  EFC39872.1 197 LTLLNIADNRICVEGAKSIS 216
                 899**************996 PP

  == domain 5  score: 15.1 bits;  conditional E-value: 9.7e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++s+N+Ig +Ga+ ++
  EFC39872.1 221 LTSLSISDNEIGVVGAKLIS 240
                 9***************9985 PP

  == domain 6  score: 18.3 bits;  conditional E-value: 8.9e-07
       LRR_6   4 hLteLdLsgNdIgDeGaeaL 23 
                  Lt L++s N+IgDeGa+ +
  EFC39872.1 244 QLTLLNISNNEIGDEGAKFI 263
                 5899*************977 PP

  == domain 7  score: 9.2 bits;  conditional E-value: 0.00078
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 L +Ld+s N I+ eGa++++
  EFC39872.1 269 LISLDISNNLIDIEGAKSIS 288
                 679**************996 PP

  == domain 8  score: 14.5 bits;  conditional E-value: 1.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++ +N+IgDeG++ +
  EFC39872.1 293 LTSLEIYYNEIGDEGVKFI 311
                 9***************977 PP

  == domain 9  score: 18.6 bits;  conditional E-value: 7.2e-07
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+sgN+Ig  Ga++++
  EFC39872.1 317 LTSLDISGNQIGVGGAKSIS 336
                 9****************996 PP

  == domain 10  score: 13.0 bits;  conditional E-value: 4.5e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++ +N IgDeGa ++
  EFC39872.1 341 LTFLQIFSNRIGDEGANSI 359
                 999************9776 PP

  == domain 11  score: 17.6 bits;  conditional E-value: 1.5e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++ +N+IgDeG++ +
  EFC39872.1 365 LTSLNIYYNQIGDEGVKFI 383
                 9***************977 PP

  == domain 12  score: 16.2 bits;  conditional E-value: 4.2e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+Ld+ gN+Ig  Ga++++
  EFC39872.1 389 LTSLDIGGNQIGVGGAKSIS 408
                 9****************996 PP

  == domain 13  score: 14.7 bits;  conditional E-value: 1.3e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L++ +N IgDeG++ +
  EFC39872.1 413 LTFLQIFSNRIGDEGVKFI 431
                 999*************977 PP

  == domain 14  score: 25.0 bits;  conditional E-value: 6.3e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++sgN IgDeGa++++
  EFC39872.1 437 LTSLNISGNRIGDEGAKSIS 456
                 9****************996 PP

  == domain 15  score: 15.3 bits;  conditional E-value: 8.6e-06
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt L +s+N+IgDeG++ +
  EFC39872.1 461 LTLLYISSNEIGDEGVKFI 479
                 88899***********977 PP

  == domain 16  score: 12.1 bits;  conditional E-value: 9.2e-05
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt L++ +N IgDeG+++++
  EFC39872.1 485 LTLLQIYSNRIGDEGVKSIS 504
                 77889999*********996 PP

  == domain 17  score: 24.9 bits;  conditional E-value: 6.9e-09
       LRR_6   5 LteLdLsgNdIgDeGaeaLa 24 
                 Lt+L++sgN IgDeG+++++
  EFC39872.1 509 LTSLNISGNRIGDEGVKSIS 528
                 9****************996 PP

  == domain 18  score: 21.5 bits;  conditional E-value: 8.5e-08
       LRR_6   5 LteLdLsgNdIgDeGaeaL 23 
                 Lt+L++s N IgDeG++ L
  EFC39872.1 533 LTSLNISNNRIGDEGVKLL 551
                 9***************986 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.9   0.0       1.6   2.9e+03       8      22 ..      43      57 ..      42      64 .. 0.81
   2 !   30.5   0.0   1.3e-10   2.3e-07       2      61 .]     124     183 ..     123     183 .. 0.98
   3 !   31.9   1.0   4.7e-11   8.5e-08       2      61 .]     196     255 ..     195     255 .. 0.98
   4 !   18.1   0.1   9.2e-07    0.0017      20      61 .]     262     303 ..     259     303 .. 0.91
   5 !   25.9   0.0   3.4e-09   6.2e-06       2      61 .]     292     351 ..     291     351 .. 0.98
   6 !   25.5   0.0   4.7e-09   8.4e-06       2      61 .]     364     423 ..     357     423 .. 0.98
   7 !   20.5   0.0   1.6e-07   0.00029      22      61 .]     432     471 ..     426     473 .. 0.75
   8 !   30.2   0.3   1.6e-10   2.8e-07       2      61 .]     484     543 ..     478     543 .. 0.98

  Alignments for each domain:
  == domain 1  score: -1.9 bits;  conditional E-value: 1.6
                -TTS--SEE-TTSST CS
       LRR_8  8 LsnNrltslddeaFk 22
                +++  ++ +dd++F 
  EFC39872.1 43 ICFEIISMIDDSWFI 57
                67778999*****95 PP

  == domain 2  score: 30.5 bits;  conditional E-value: 1.3e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL +  Nr+ + + ++ + +++L+ Ld+ +N++ +  + ++s +++L+sL++sgNr+
  EFC39872.1 124 QLTSLGIAENRIGDEGVKFISEMKQLTLLDICCNEIGVEGATSISEMKQLTSLNISGNRI 183
                 7*********************************************************98 PP

  == domain 3  score: 31.9 bits;  conditional E-value: 4.7e-11
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L++ +Nr+ + + ++ + +++L++L++s+N++ ++ ++ +s +++L+ L++s+N +
  EFC39872.1 196 QLTLLNIADNRICVEGAKSISEMKQLTSLSISDNEIGVVGAKLISEMNQLTLLNISNNEI 255
                 79********************************************************87 PP

  == domain 4  score: 18.1 bits;  conditional E-value: 9.2e-07
                 SSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  20 aFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + + +++L +Ld+snNl++   ++++s +++L+sL + +N +
  EFC39872.1 262 FISEMKQLISLDISNNLIDIEGAKSISEMKQLTSLEIYYNEI 303
                 55679*******************************999976 PP

  == domain 5  score: 25.9 bits;  conditional E-value: 3.4e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL +  N + + + ++ +++++L++Ld+s N++ +  ++++s +++L++L + +Nr+
  EFC39872.1 292 QLTSLEIYYNEIGDEGVKFISKMEQLTSLDISGNQIGVGGAKSISEMKQLTFLQIFSNRI 351
                 79********************************************************97 PP

  == domain 6  score: 25.5 bits;  conditional E-value: 4.7e-09
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +LtsL++  N++ + + ++ + +++L++Ld++ N++ +  ++++s +++L++L + +Nr+
  EFC39872.1 364 QLTSLNIYYNQIGDEGVKFISEMEQLTSLDIGGNQIGVGGAKSISEMKQLTFLQIFSNRI 423
                 7*********************************************************97 PP

  == domain 7  score: 20.5 bits;  conditional E-value: 1.6e-07
                 TT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8  22 kglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 + +++L++L++s N++    ++++s +++L+ L++s+N +
  EFC39872.1 432 SEMKQLTSLNISGNRIGDEGAKSISEMKQLTLLYISSNEI 471
                 5577888888888888888888888888888888888865 PP

  == domain 8  score: 30.2 bits;  conditional E-value: 1.6e-10
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 +Lt L++ +Nr+ + + ++ + +++L++L++s N++     +++s +++L+sL++s+Nr+
  EFC39872.1 484 QLTLLQIYSNRIGDEGVKSISEMKQLTSLNISGNRIGDEGVKSISEMKQLTSLNISNNRI 543
                 799*******************************************************98 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.0    0.0004      0.72       1      36 [.     123     159 ..     123     169 .. 0.84
   2 !   19.9   0.2   4.1e-07   0.00074       1      36 [.     171     207 ..     171     217 .. 0.86
   3 ?    5.9   0.0      0.01        18      18      38 ..     217     230 ..     208     236 .. 0.75
   4 !   17.8   1.0   1.9e-06    0.0034       1      38 [.     219     257 ..     219     260 .. 0.86
   5 !   19.3   3.4   6.2e-07    0.0011       2      41 ..     244     283 ..     243     289 .. 0.85
   6 !   17.6   0.2   2.2e-06    0.0039       1      37 [.     267     304 ..     267     307 .. 0.77
   7 !   16.8   0.0   3.9e-06     0.007       1      36 [.     291     327 ..     291     337 .. 0.88
   8 !   18.4   0.0   1.2e-06    0.0021       1      38 [.     339     377 ..     339     380 .. 0.86
   9 !   18.6   0.0     1e-06    0.0019       1      36 [.     363     399 ..     363     409 .. 0.87
  10 !   21.9   0.0   9.5e-08   0.00017       1      38 [.     411     449 ..     411     457 .. 0.88
  11 !   20.7   0.2   2.3e-07   0.00042       1      37 [.     435     472 ..     435     480 .. 0.86
  12 !   12.2   0.1   0.00011      0.19       1      38 [.     459     497 ..     459     504 .. 0.86
  13 !   18.4   0.1   1.2e-06    0.0022       1      38 [.     483     521 ..     483     528 .. 0.86
  14 !   25.6   0.9   6.6e-09   1.2e-05       1      38 [.     507     545 ..     507     552 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.0004
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L ++ N++ d +  + + +++L+ Ld+  +n i
  EFC39872.1 123 KQLTSLGIAENRIGDEGVkFISeMKQLTLLDI-CCNEI 159
                 589************99996655********9.55565 PP

  == domain 2  score: 19.9 bits;  conditional E-value: 4.1e-07
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L++s+N++ d +  l + +++L+ L++ +N +i
  EFC39872.1 171 KQLTSLNISGNRIGDEGAkLISeMKQLTLLNIADN-RI 207
                 58*************99996655*********777.65 PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.01
                 -HHH-TT--EEE-.-S----- CS
       LRR_4  18 lleklpnLkeLdLsgNnlitd 38 
                     +++L++L++s+N     
  EFC39872.1 217 E---MKQLTSLSISDN----E 230
                 3...999999999888....3 PP

  == domain 4  score: 17.8 bits;  conditional E-value: 1.9e-06
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L++s+N +  ++  l + + +L+ L++s+N  i+d
  EFC39872.1 219 KQLTSLSISDNEIGVVGAkLISeMNQLTLLNISNN-EIGD 257
                 58*************99996655*********555.7765 PP

  == domain 5  score: 19.3 bits;  conditional E-value: 6.2e-07
                 S--EEE--SS---E-S-.HHH.-TT--EEE-.-S-----GGG CS
       LRR_4   2 nLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitdlde 41 
                 +L+ L++snN + d +  + + +++L +Ld+ +Nnli d+++
  EFC39872.1 244 QLTLLNISNNEIGDEGAkFISeMKQLISLDI-SNNLI-DIEG 283
                 5999**********999*6655*********.55577.8865 PP

  == domain 6  score: 17.6 bits;  conditional E-value: 2.2e-06
                 SS--EEE--SS---E-S-...HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl...leklpnLkeLdLsgNnlit 37 
                 ++L++Ld+snN +  i++   ++ +++L++L +  N  i+
  EFC39872.1 267 KQLISLDISNNLID-IEGaksISEMKQLTSLEIYYN-EIG 304
                 589******85555.899665335*********777.554 PP

  == domain 7  score: 16.8 bits;  conditional E-value: 3.9e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnli 36 
                 ++L++L +  N + d +   ++k+ +L++Ld+sgN +i
  EFC39872.1 291 KQLTSLEIYYNEIGDEGVkfISKMEQLTSLDISGN-QI 327
                 58*************99995557************.66 PP

  == domain 8  score: 18.4 bits;  conditional E-value: 1.2e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L +++N++ d +   ++ +++L++L++  N +i+d
  EFC39872.1 339 KQLTFLQIFSNRIGDEGAnsISEMKQLTSLNIYYN-QIGD 377
                 58*************99986445*********777.9876 PP

  == domain 9  score: 18.6 bits;  conditional E-value: 1e-06
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnli 36 
                 ++L++L++  Nq+ d +  + + + +L++Ld+ gN +i
  EFC39872.1 363 KQLTSLNIYYNQIGDEGVkFISeMEQLTSLDIGGN-QI 399
                 58*************99996655*********878.77 PP

  == domain 10  score: 21.9 bits;  conditional E-value: 9.5e-08
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L++L +++N++ d +  + + +++L++L++sgN +i+d
  EFC39872.1 411 KQLTFLQIFSNRIGDEGVkFISeMKQLTSLNISGN-RIGD 449
                 58*************99996655************.7765 PP

  == domain 11  score: 20.7 bits;  conditional E-value: 2.3e-07
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S---- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlit 37 
                 ++L++L++s+N++ d +   ++ +++L+ L++s+N  i+
  EFC39872.1 435 KQLTSLNISGNRIGDEGAksISEMKQLTLLYISSN-EIG 472
                 58*************99986445*********999.554 PP

  == domain 12  score: 12.2 bits;  conditional E-value: 0.00011
                 SS--EEE--SS---E-S-.HHH.-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl.lek.lpnLkeLdLsgNnlitd 38 
                 ++L+ L++s+N + d +  + + +++L+ L + +N +i+d
  EFC39872.1 459 KQLTLLYISSNEIGDEGVkFISeMKQLTLLQIYSN-RIGD 497
                 589************99996655*********666.8865 PP

  == domain 13  score: 18.4 bits;  conditional E-value: 1.2e-06
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L+ L + +N++ d +   ++ +++L++L++sgN +i+d
  EFC39872.1 483 KQLTLLQIYSNRIGDEGVksISEMKQLTSLNISGN-RIGD 521
                 57999*********999986445************.7765 PP

  == domain 14  score: 25.6 bits;  conditional E-value: 6.6e-09
                 SS--EEE--SS---E-S-..HHH-TT--EEE-.-S----- CS
       LRR_4   1 pnLevLdLsnNqltdipl..leklpnLkeLdLsgNnlitd 38 
                 ++L++L++s+N++ d +   ++ +++L++L++ +Nn+i+d
  EFC39872.1 507 KQLTSLNISGNRIGDEGVksISEMKQLTSLNI-SNNRIGD 545
                 58************999986445*********.6669876 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.0      0.64   1.2e+03       2      20 ..     149     167 ..     148     170 .. 0.77
   2 !    6.6   0.0    0.0088        16       1      18 [.     172     189 ..     172     194 .. 0.80
   3 ?    1.7   0.0      0.34   6.1e+02       2      21 ..     197     216 ..     196     218 .. 0.81
   4 ?    1.7   0.0      0.34   6.1e+02       1      14 [.     220     233 ..     220     242 .. 0.78
   5 ?    4.9   0.0     0.031        55       2      18 ..     245     261 ..     244     266 .. 0.79
   6 ?    4.3   0.0     0.049        88       2      15 ..     269     282 ..     268     290 .. 0.74
   7 ?    0.3   0.0      0.99   1.8e+03       1      20 [.     292     311 ..     292     314 .. 0.78
   8 !    7.7   0.0    0.0038       6.8       1      21 [.     316     336 ..     316     338 .. 0.85
   9 ?    0.2   0.0       1.1     2e+03       2      21 ..     341     360 ..     340     362 .. 0.87
  10 ?    3.1   0.0      0.12   2.1e+02       1      17 [.     364     380 ..     364     386 .. 0.79
  11 ?    6.3   0.0     0.011        20       1      21 [.     388     408 ..     388     411 .. 0.86
  12 !    8.5   0.0     0.002       3.6       1      21 [.     436     456 ..     436     458 .. 0.88
  13 ?    2.2   0.0      0.24   4.4e+02       2      17 ..     461     476 ..     460     482 .. 0.78
  14 ?   -1.6   0.0       4.3   7.8e+03       2      21 ..     485     504 ..     484     506 .. 0.81
  15 !    8.1   0.0    0.0028         5       1      21 [.     508     528 ..     508     530 .. 0.87
  16 !    6.8   0.3     0.007        13       1      16 [.     532     547 ..     532     555 .. 0.79

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.64
       LRR_1   2 LrhLdLsnnpllglppnsf 20 
                 L+ Ld++ n ++  ++ s+
  EFC39872.1 149 LTLLDICCNEIGVEGATSI 167
                 899******9977666665 PP

  == domain 2  score: 6.6 bits;  conditional E-value: 0.0088
       LRR_1   1 nLrhLdLsnnpllglppn 18 
                 +L++L++s+n++++ ++ 
  EFC39872.1 172 QLTSLNISGNRIGDEGAK 189
                 599********9776655 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.34
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L++ +n++   ++ s++
  EFC39872.1 197 LTLLNIADNRICVEGAKSIS 216
                 899*******9877777765 PP

  == domain 4  score: 1.7 bits;  conditional E-value: 0.34
       LRR_1   1 nLrhLdLsnnpllg 14 
                 +L++L +s+n ++ 
  EFC39872.1 220 QLTSLSISDNEIGV 233
                 599*******9854 PP

  == domain 5  score: 4.9 bits;  conditional E-value: 0.031
       LRR_1   2 LrhLdLsnnpllglppn 18 
                 L+ L++snn +++ ++ 
  EFC39872.1 245 LTLLNISNNEIGDEGAK 261
                 899*******9877665 PP

  == domain 6  score: 4.3 bits;  conditional E-value: 0.049
       LRR_1   2 LrhLdLsnnpllgl 15 
                 L +Ld+snn ++  
  EFC39872.1 269 LISLDISNNLIDIE 282
                 899******98544 PP

  == domain 7  score: 0.3 bits;  conditional E-value: 0.99
       LRR_1   1 nLrhLdLsnnpllglppnsf 20 
                 +L++L + +n +++ +   +
  EFC39872.1 292 QLTSLEIYYNEIGDEGVKFI 311
                 599*******9987766655 PP

  == domain 8  score: 7.7 bits;  conditional E-value: 0.0038
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld+s+n+++  ++ s++
  EFC39872.1 316 QLTSLDISGNQIGVGGAKSIS 336
                 599*********988888876 PP

  == domain 9  score: 0.2 bits;  conditional E-value: 1.1
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L + +n++++ ++ns++
  EFC39872.1 341 LTFLQIFSNRIGDEGANSIS 360
                 88899999*********997 PP

  == domain 10  score: 3.1 bits;  conditional E-value: 0.12
       LRR_1   1 nLrhLdLsnnpllglpp 17 
                 +L++L++ +n++++ + 
  EFC39872.1 364 QLTSLNIYYNQIGDEGV 380
                 599********977655 PP

  == domain 11  score: 6.3 bits;  conditional E-value: 0.011
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++Ld+++n+++  ++ s++
  EFC39872.1 388 QLTSLDIGGNQIGVGGAKSIS 408
                 599*********988888876 PP

  == domain 12  score: 8.5 bits;  conditional E-value: 0.002
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++s+n++++ ++ s++
  EFC39872.1 436 QLTSLNISGNRIGDEGAKSIS 456
                 599*********999999987 PP

  == domain 13  score: 2.2 bits;  conditional E-value: 0.24
       LRR_1   2 LrhLdLsnnpllglpp 17 
                 L+ L++s+n +++ + 
  EFC39872.1 461 LTLLYISSNEIGDEGV 476
                 899******9976655 PP

  == domain 14  score: -1.6 bits;  conditional E-value: 4.3
       LRR_1   2 LrhLdLsnnpllglppnsfq 21 
                 L+ L + +n++++ +  s++
  EFC39872.1 485 LTLLQIYSNRIGDEGVKSIS 504
                 78899999999988888876 PP

  == domain 15  score: 8.1 bits;  conditional E-value: 0.0028
       LRR_1   1 nLrhLdLsnnpllglppnsfq 21 
                 +L++L++s+n++++ +  s++
  EFC39872.1 508 QLTSLNISGNRIGDEGVKSIS 528
                 599*********999988876 PP

  == domain 16  score: 6.8 bits;  conditional E-value: 0.007
       LRR_1   1 nLrhLdLsnnpllglp 16 
                 +L++L++snn++++ +
  EFC39872.1 532 QLTSLNISNNRIGDEG 547
                 599********97665 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.7   0.5   0.00065       1.2      12     146 ..      65     201 ..      59     205 .. 0.59
   2 !   13.0   0.7   3.1e-05     0.055      42     146 ..     219     321 ..     211     323 .. 0.65
   3 !    7.0   0.1    0.0021       3.8      43     126 ..     268     352 ..     264     370 .. 0.84
   4 !    5.4   0.0    0.0064        11      41     120 ..     314     394 ..     307     401 .. 0.76
   5 !    9.1   0.0   0.00048      0.85      43     127 ..     388     473 ..     381     489 .. 0.77
   6 !    8.2   0.2   0.00088       1.6      50     125 ..     467     543 ..     460     549 .. 0.74

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00065
       LRR_9  12 saqyinairereldlrgykipvien...lGatldqf.dtidlsdndirkldgfPl...lkrlktlllnnnrivriaegleevlPnleelvltnnelqel 103
                 s+q++n irer   +  +k    e    l     qf ++i      +  ld+  +   +k+l +l +++nri    ++  +++ ++++l l + + +e+
  EFC39872.1  65 SKQFFNVIRERSKLVIQFKKKFTEKrieLFM-KSQFmNSIANVKFSVYSLDNAKFiseMKQLTSLGIAENRIG---DEGVKFISEMKQLTLLDICCNEI 159
                 5677777777766666665555543111222.33442566666666777777766111556667778888875...55556777777777777666666 PP

       LRR_9 104 ad..ldPlaslkklellsllknpvtnkkeyrlyviyklkqlrlld 146
                 +      + ++k+l++l +  n +    +    +i  +kql+ll+
  EFC39872.1 160 GVegATSISEMKQLTSLNISGNRIG---DEGAKLISEMKQLTLLN 201
                 5301355666666666666666655...44567888888888876 PP

  == domain 2  score: 13.0 bits;  conditional E-value: 3.1e-05
       LRR_9  42 dqfdtidlsdndirkldg..fPllkrlktlllnnnrivriaegleevlPnleelvlt..nnelqeladldPlaslkklellsllknpvtnkkeyrlyvi 136
                  q+ ++ +sdn+i  +    +  +++l  l ++nn    i+++ ++++ ++++l+    +n+l ++   + + ++k+l++l +  n + ++       i
  EFC39872.1 219 KQLTSLSISDNEIGVVGAklISEMNQLTLLNISNNE---IGDEGAKFISEMKQLISLdiSNNLIDIEGAKSISEMKQLTSLEIYYNEIGDE---GVKFI 311
                 68889999****987654225567777777777776...5666677777777776431134455566667777788888877777766543...45667 PP

       LRR_9 137 yklkqlrlld 146
                  k++ql+ ld
  EFC39872.1 312 SKMEQLTSLD 321
                 7777777666 PP

  == domain 3  score: 7.0 bits;  conditional E-value: 0.0021
       LRR_9  43 qfdtidlsdn..dirkldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvt 126
                 q+ ++d+s+n  di    ++  +k+l +l +  n i   + ++   + +l++l +++n++   +  + + ++k+l++l +++n + 
  EFC39872.1 268 QLISLDISNNliDIEGAKSISEMKQLTSLEIYYNEIGDEGVKFISKMEQLTSLDISGNQIGVGG-AKSISEMKQLTFLQIFSNRIG 352
                 666788888866777888899999999999999999999999999999999999*****98655.599************999876 PP

  == domain 4  score: 5.4 bits;  conditional E-value: 0.0064
       LRR_9  41 ldqfdtidlsdndir..kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsl 120
                 ++q+ ++d+s n+i      ++  +k+l  l + +nri   + +    + +l++l +  n++ + + ++ + ++++l++l +
  EFC39872.1 314 MEQLTSLDISGNQIGvgGAKSISEMKQLTFLQIFSNRIGDEGANSISEMKQLTSLNIYYNQIGDEG-VKFISEMEQLTSLDI 394
                 578888899999885224677888999999999999999888888888888999988888888754.477777777777766 PP

  == domain 5  score: 9.1 bits;  conditional E-value: 0.00048
       LRR_9  43 qfdtidlsdndir..kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpvtn 127
                 q+ ++d+  n+i      ++  +k+l  l + +nri   + ++   + +l++l +++n++ + +  + + ++k+l+ll + +n + +
  EFC39872.1 388 QLTSLDIGGNQIGvgGAKSISEMKQLTFLQIFSNRIGDEGVKFISEMKQLTSLNISGNRIGDEGA-KSISEMKQLTLLYISSNEIGD 473
                 6666666666664113566778999999********99999999999*************99988.899999999999998887754 PP

  == domain 6  score: 8.2 bits;  conditional E-value: 0.00088
       LRR_9  50 sdndirk..ldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlaslkklellsllknpv 125
                 s n+i +  +  +  +k+l  l + +nri   + +    + +l++l +++n++ + + ++ + ++k+l++l + +n +
  EFC39872.1 467 SSNEIGDegVKFISEMKQLTLLQIYSNRIGDEGVKSISEMKQLTSLNISGNRIGDEG-VKSISEMKQLTSLNISNNRI 543
                 556664311333445677777888899998777766677889999999999999966.59999999999999988876 PP

>> DUF4347  Domain of unknown function (DUF4347)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.5   0.0      0.13   2.3e+02     103     123 ..     136     156 ..     129     165 .. 0.88
   2 ?    0.3   0.0       0.3   5.4e+02     103     122 ..     184     203 ..     165     209 .. 0.86
   3 ?    1.2   0.0      0.16   2.9e+02     103     122 ..     256     275 ..     218     279 .. 0.77
   4 !    7.7   0.0    0.0016       2.9      92     132 ..     295     333 ..     282     340 .. 0.79
   5 !    6.1   0.0    0.0051       9.2      88     131 ..     363     404 ..     353     409 .. 0.78
   6 ?    3.7   0.0     0.028        50     103     123 ..     424     444 ..     407     454 .. 0.81
   7 ?    3.7   0.0     0.028        50      93     123 ..     462     492 ..     450     502 .. 0.80
   8 ?   -1.4   0.0         1   1.8e+03     100     123 ..     495     516 ..     488     522 .. 0.75
   9 ?   -1.4   0.0       1.1   1.9e+03     103     129 ..     520     544 ..     503     547 .. 0.78

  Alignments for each domain:
  == domain 1  score: 1.5 bits;  conditional E-value: 0.13
     DUF4347 103 geaGeafvekLaqltgadvaA 123
                 g++G +f+++++qlt  d+  
  EFC39872.1 136 GDEGVKFISEMKQLTLLDICC 156
                 689************999965 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.3
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +++++++qlt  ++a
  EFC39872.1 184 GDEGAKLISEMKQLTLLNIA 203
                 578************99998 PP

  == domain 3  score: 1.2 bits;  conditional E-value: 0.16
     DUF4347 103 geaGeafvekLaqltgadva 122
                 g++G +f+++++ql+  d++
  EFC39872.1 256 GDEGAKFISEMKQLISLDIS 275
                 78899999999999988885 PP

  == domain 4  score: 7.7 bits;  conditional E-value: 0.0016
     DUF4347  92 dillYgCnvAageaGeafvekLaqltgadvaAstdltGnaa 132
                  + +Y  +++  ++G +f++k++qlt  d++ ++  +G a+
  EFC39872.1 295 SLEIYYNEIG--DEGVKFISKMEQLTSLDISGNQIGVGGAK 333
                 5666666665..56****************99988888765 PP

  == domain 5  score: 6.1 bits;  conditional E-value: 0.0051
     DUF4347  88 sedadillYgCnvAageaGeafvekLaqltgadvaAstdltGna 131
                 ++   + +Y  +++   +G +f+++++qlt  d+  ++  +G a
  EFC39872.1 363 KQLTSLNIYYNQIGD--EGVKFISEMEQLTSLDIGGNQIGVGGA 404
                 455566677777765..5****************9888777766 PP

  == domain 6  score: 3.7 bits;  conditional E-value: 0.028
     DUF4347 103 geaGeafvekLaqltgadvaA 123
                 g++G +f+++++qlt  +++ 
  EFC39872.1 424 GDEGVKFISEMKQLTSLNISG 444
                 567**************9964 PP

  == domain 7  score: 3.7 bits;  conditional E-value: 0.028
     DUF4347  93 illYgCnvAageaGeafvekLaqltgadvaA 123
                  llY  +   g++G +f+++++qlt  ++ +
  EFC39872.1 462 TLLYISSNEIGDEGVKFISEMKQLTLLQIYS 492
                 57888888899**************998865 PP

  == domain 8  score: -1.4 bits;  conditional E-value: 1
     DUF4347 100 vAageaGeafvekLaqltgadvaA 123
                 ++  ++G + +++++qlt  +++ 
  EFC39872.1 495 IG--DEGVKSISEMKQLTSLNISG 516
                 54..569999********999964 PP

  == domain 9  score: -1.4 bits;  conditional E-value: 1.1
     DUF4347 103 geaGeafvekLaqltgadvaAstdltG 129
                 g++G + +++++qlt  ++  s++++G
  EFC39872.1 520 GDEGVKSISEMKQLTSLNI--SNNRIG 544
                 5679999999999999998..445555 PP

>> DUF424  Protein of unknown function (DUF424)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.7   0.0      0.99   1.8e+03      23      62 ..      87     134 ..      82     150 .. 0.58
   2 ?    4.7   0.0     0.021        37      21      63 ..     141     183 ..     137     189 .. 0.73
   3 ?    4.3   0.0     0.027        48      44      66 ..     188     210 ..     183     214 .. 0.87
   4 ?    3.7   0.5     0.042        75       8      57 ..     222     276 ..     215     327 .. 0.72
   5 ?   -0.2   0.0      0.69   1.2e+03      43      58 ..     355     370 ..     329     382 .. 0.77
   6 ?    2.5   0.0     0.096   1.7e+02      44      63 ..     428     447 ..     408     454 .. 0.83
   7 !    6.7   0.1    0.0049       8.7      19      65 ..     475     521 ..     456     526 .. 0.71
   8 ?   -0.1   0.0      0.63   1.1e+03      44      63 ..     524     543 ..     520     550 .. 0.79

  Alignments for each domain:
  == domain 1  score: -0.7 bits;  conditional E-value: 0.99
                 EETTEEEE--HHHH--EEE........-HHHHHHHHHHHEEEEEESHH CS
      DUF424  23 kegelllnvsegfyggela........seeeaikeLekatiaNivgee 62 
                 +e+ ++l  + +f  +  +        +++++i+e++++t   i +++
  EFC39872.1  87 TEKRIELFMKSQFMNSIANvkfsvyslDNAKFISEMKQLTSLGIAENR 134
                 555555555555544444333333333455777777777776666655 PP

  == domain 2  score: 4.7 bits;  conditional E-value: 0.021
                 EEEETTEEEE--HHHH--EEE-HHHHHHHHHHHEEEEEESHHH CS
      DUF424  21 tfkegelllnvsegfyggelaseeeaikeLekatiaNivgeea 63 
                 +f  ++ +l++   +  +  ++ +++i+e++++t  Ni g+++
  EFC39872.1 141 KFISEMKQLTLLDICCNEIGVEGATSISEMKQLTSLNISGNRI 183
                 5666665555555555555566679***************985 PP

  == domain 3  score: 4.3 bits;  conditional E-value: 0.027
                 HHHHHHHHHHEEEEEESHHHHHH CS
      DUF424  44 eeaikeLekatiaNivgeeavvl 66 
                 +++i+e++++t  Ni +++++v+
  EFC39872.1 188 AKLISEMKQLTLLNIADNRICVE 210
                 5789***************9986 PP

  == domain 4  score: 3.7 bits;  conditional E-value: 0.042
                 EEEEEEEGG..GTT-EEEETT...EEEE--HHHH--EEE-HHHHHHHHHHH...EEEE CS
      DUF424   8 klvavcdke..llgktfkege...lllnvsegfyggelaseeeaikeLeka...tiaN 57 
                 + ++++d+e  ++g ++  ++   +lln+s+  +g e a   ++i+e++++   +i+N
  EFC39872.1 222 TSLSISDNEigVVGAKLISEMnqlTLLNISNNEIGDEGA---KFISEMKQLislDISN 276
                 566666666334777777777555677777887777777...6666666654444443 PP

  == domain 5  score: -0.2 bits;  conditional E-value: 0.69
                 HHHHHHHHHHHEEEEE CS
      DUF424  43 eeeaikeLekatiaNi 58 
                  +++i+e++++t  Ni
  EFC39872.1 355 GANSISEMKQLTSLNI 370
                 3578999999999998 PP

  == domain 6  score: 2.5 bits;  conditional E-value: 0.096
                 HHHHHHHHHHEEEEEESHHH CS
      DUF424  44 eeaikeLekatiaNivgeea 63 
                  ++i+e++++t  Ni g+++
  EFC39872.1 428 VKFISEMKQLTSLNISGNRI 447
                 589**************985 PP

  == domain 7  score: 6.7 bits;  conditional E-value: 0.0049
                 T-EEEETTEEEE--HHHH--EEE-H.HHHHHHHHHHEEEEEESHHHHH CS
      DUF424  19 gktfkegelllnvsegfyggelase.eeaikeLekatiaNivgeeavv 65 
                 g +f  ++ +l++  ++y++++ +e  ++i+e++++t  Ni g+++ +
  EFC39872.1 475 GVKFISEMKQLTLL-QIYSNRIGDEgVKSISEMKQLTSLNISGNRIGD 521
                 56677777666664.4677777643379***************99755 PP

  == domain 8  score: -0.1 bits;  conditional E-value: 0.63
                 HHHHHHHHHHEEEEEESHHH CS
      DUF424  44 eeaikeLekatiaNivgeea 63 
                  ++i+e++++t  Ni  +++
  EFC39872.1 524 VKSISEMKQLTSLNISNNRI 543
                 57999*********987765 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.9   4.9     0.012        21      22     140 ..     136     261 ..      47     279 .. 0.79
   2 ?    5.3   7.3     0.009        16      22     157 ..     232     374 ..     222     399 .. 0.77
   3 ?   13.2   3.1   3.3e-05     0.059      21     136 ..     421     545 ..     399     555 .. 0.78

  Alignments for each domain:
  == domain 1  score: 4.9 bits;  conditional E-value: 0.012
                 SS-SEEE-SSS-.....EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---SEEE-TT.--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEEST CS
  Beta_helix  22 ggyGiylrgssn....vvienneiannsgsGiyilgs.snntisnntisdnngggialf.gasnnlienneitdnggsGiyln.yssnntienNiidnn 113
                 g+ G+++ + ++      i  nei   + + i+  ++ +  +is+n+i d ++  i  + +     i +n+i   g   i+ + + ++++i++N i  +
  EFC39872.1 136 GDEGVKFISEMKqltlLDICCNEIGVEGATSISEMKQlTSLNISGNRIGDEGAKLISEMkQLTLLNIADNRICVEGAKSISEMkQLTSLSISDNEIGVV 234
                 556666666666542222223666667777777777789999999999999966666554777788999999999999996665799999999999999 PP

                 T--SEE---TT---EEES-EEES-SSE CS
  Beta_helix 114 agsGividdsssnvtvtnNtitnnkga 140
                 ++  i+ +++ + ++++nN i + + +
  EFC39872.1 235 GAKLISEMNQLTLLNISNNEIGDEGAK 261
                 999999999999999999999876644 PP

  == domain 2  score: 5.3 bits;  conditional E-value: 0.009
                 SS-SEEE-SSS-.....EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EEEST CS
  Beta_helix  22 ggyGiylrgssn....vvienneiannsgsGiyilgs.snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntienNiidnn 113
                 g  G +l + +n      i+nnei + +   i+  ++     isnn i   +  +   +++     i++nei d g   i+ + + ++++i++N+i   
  EFC39872.1 232 GVVGAKLISEMNqltlLNISNNEIGDEGAKFISEMKQlISLDISNNLIDIEGaKSISEMKQLTSLEIYYNEIGDEGVKFISKMeQLTSLDISGNQIGVG 330
                 44577777777777777888888888555555555556778888888855553355566699999999999999977666433358889*******999 PP

                 T--SEE---TT---EEES-EEES-SSEEEE-TT-SS--EEES-E CS
  Beta_helix 114 agsGividdsssnvtvtnNtitnnkgaGiavvgsssnvtvrnNt 157
                 ++  i+ + + + + ++ N+i + + ++i  + + +++ ++ N+
  EFC39872.1 331 GAKSISEMKQLTFLQIFSNRIGDEGANSISEMKQLTSLNIYYNQ 374
                 99999999999999999999999999999877777766666665 PP

  == domain 3  score: 13.2 bits;  conditional E-value: 3.3e-05
                 -..SS-SEEE-SSS-.....EEES-EEES-SS-SEEE-TT.-S-EEES-EEE---.SEEE-TT--S--EEES-EEES-SS-SEE-T.T-S--EEES-EE CS
  Beta_helix  21 s..ggyGiylrgssn....vvienneiannsgsGiyilgs.snntisnntisdnn.gggialfgasnnlienneitdnggsGiyln.yssnntienNii 110
                 +  g+ G+++ + ++      i++n+i + +   i+  ++ +   is n+i d +  +   +++     i+ n+i d g   i+ + + +++ i++N+i
  EFC39872.1 421 NriGDEGVKFISEMKqltsLNISGNRIGDEGAKSISEMKQlTLLYISSNEIGDEGvKFISEMKQLTLLQIYSNRIGDEGVKSISEMkQLTSLNISGNRI 519
                 245788888888888777777788888888888888877788888888888888877777788888888999999999999996664788899999999 PP

                 ESTT--SEE---TT---EEES-EEES CS
  Beta_helix 111 dnnagsGividdsssnvtvtnNtitn 136
                  + +   i+ + + ++++++nN+i +
  EFC39872.1 520 GDEGVKSISEMKQLTSLNISNNRIGD 545
                 99998999999888899999999864 PP

>> ApoB100_C  Apolipoprotein B100 C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   0.0      0.33   5.9e+02      19      32 ..     117     130 ..     111     133 .. 0.86
   2 ?   -0.7   0.0      0.79   1.4e+03      17      28 ..     139     150 ..     128     155 .. 0.75
   3 ?   -0.5   0.0      0.68   1.2e+03      15      32 ..     185     202 ..     176     206 .. 0.79
   4 ?   -1.3   0.0       1.2   2.2e+03      19      33 ..     213     227 ..     199     229 .. 0.85
   5 ?    6.2   0.1    0.0056        10      15      34 ..     257     276 ..     244     279 .. 0.83
   6 ?   -2.2   0.1       2.3   4.1e+03      11      30 ..     301     320 ..     285     323 .. 0.61
   7 ?   -1.0   0.0      0.96   1.7e+03       6      32 ..     344     370 ..     340     372 .. 0.87
   8 ?    1.6   0.1      0.15   2.8e+02       9      32 ..     371     394 ..     364     396 .. 0.86
   9 ?    6.3   0.0    0.0054       9.6       6      32 ..     416     442 ..     412     444 .. 0.92
  10 ?    0.2   0.1      0.42   7.5e+02      15      32 ..     473     490 ..     464     495 .. 0.78
  11 ?   -0.7   0.1      0.82   1.5e+03       6      32 ..     488     514 ..     484     516 .. 0.86
  12 ?   -2.7   0.0       3.3   5.9e+03      19      34 ..     525     540 ..     518     541 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.33
   ApoB100_C  19 kliaeskrLiDLsI 32 
                 k+i+e k+L  L I
  EFC39872.1 117 KFISEMKQLTSLGI 130
                 9********98877 PP

  == domain 2  score: -0.7 bits;  conditional E-value: 0.79
   ApoB100_C  17 yEkliaeskrLi 28 
                   k+i+e k+L 
  EFC39872.1 139 GVKFISEMKQLT 150
                 559******996 PP

  == domain 3  score: -0.5 bits;  conditional E-value: 0.68
   ApoB100_C  15 dyyEkliaeskrLiDLsI 32 
                 d   kli+e k+L  L I
  EFC39872.1 185 DEGAKLISEMKQLTLLNI 202
                 55669*******987766 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 1.2
   ApoB100_C  19 kliaeskrLiDLsIe 33 
                 k i+e k+L  LsI 
  EFC39872.1 213 KSISEMKQLTSLSIS 227
                 779*********995 PP

  == domain 5  score: 6.2 bits;  conditional E-value: 0.0056
   ApoB100_C  15 dyyEkliaeskrLiDLsIek 34 
                 d   k+i+e k+Li L I +
  EFC39872.1 257 DEGAKFISEMKQLISLDISN 276
                 55669***********9976 PP

  == domain 6  score: -2.2 bits;  conditional E-value: 2.3
   ApoB100_C  11 dqlsdyyEkliaeskrLiDL 30 
                 + + d   k+i++ ++L  L
  EFC39872.1 301 NEIGDEGVKFISKMEQLTSL 320
                 44444445777777776655 PP

  == domain 7  score: -1.0 bits;  conditional E-value: 0.96
   ApoB100_C   6 LqefsdqlsdyyEkliaeskrLiDLsI 32 
                 Lq fs+++ d     i+e k+L  L I
  EFC39872.1 344 LQIFSNRIGDEGANSISEMKQLTSLNI 370
                 899999999999999******998877 PP

  == domain 8  score: 1.6 bits;  conditional E-value: 0.15
   ApoB100_C   9 fsdqlsdyyEkliaeskrLiDLsI 32 
                  ++q+ d   k+i+e ++L  L I
  EFC39872.1 371 YYNQIGDEGVKFISEMEQLTSLDI 394
                 6899999999********988876 PP

  == domain 9  score: 6.3 bits;  conditional E-value: 0.0054
   ApoB100_C   6 LqefsdqlsdyyEkliaeskrLiDLsI 32 
                 Lq fs+++ d   k+i+e k+L  L I
  EFC39872.1 416 LQIFSNRIGDEGVKFISEMKQLTSLNI 442
                 899*******************99988 PP

  == domain 10  score: 0.2 bits;  conditional E-value: 0.42
   ApoB100_C  15 dyyEkliaeskrLiDLsI 32 
                 d   k+i+e k+L  L I
  EFC39872.1 473 DEGVKFISEMKQLTLLQI 490
                 55569*******987766 PP

  == domain 11  score: -0.7 bits;  conditional E-value: 0.82
   ApoB100_C   6 LqefsdqlsdyyEkliaeskrLiDLsI 32 
                 Lq  s+++ d   k i+e k+L  L I
  EFC39872.1 488 LQIYSNRIGDEGVKSISEMKQLTSLNI 514
                 788889999999999*******99987 PP

  == domain 12  score: -2.7 bits;  conditional E-value: 3.3
   ApoB100_C  19 kliaeskrLiDLsIek 34 
                 k i+e k+L  L I +
  EFC39872.1 525 KSISEMKQLTSLNISN 540
                 669999**99999875 PP

>> bZIP_C  Basic leucine-zipper C terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0       1.7     3e+03      63     118 ..     123     183 ..      82     189 .. 0.57
   2 ?   -0.8   0.0       1.6   2.9e+03      81     119 ..     165     208 ..     135     213 .. 0.58
   3 ?    0.9   0.1      0.49   8.8e+02     106     112 ..     315     321 ..     248     380 .. 0.59
   4 ?   -0.4   0.0       1.2   2.2e+03     101     112 ..     382     393 ..     342     428 .. 0.48
   5 ?   -1.4   0.0       2.6   4.6e+03      73     111 ..     421     440 ..     387     467 .. 0.54
   6 ?    6.6   0.1    0.0086        15      54     119 ..     474     544 ..     422     548 .. 0.85

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 1.7
      bZIP_C  63 staddlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkri 118
                 +  ++l++ +n ++d ++  + e ++l    +  +++g      ++++++ +sL+   +ri
  EFC39872.1 123 KQLTSLGIAENRIGDEGVKFISEMKQLTLLDICCNEIGvegatSISEMKQLTSLNISGNRI 183
                 4444444555555555544333333333333344555555555666667777776666665 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 1.6
      bZIP_C  81 velqekadlanaavaagkmg.....rtasLqrvasLehlqkrir 119
                 +++ e ++l + +++++ +g      ++++++ + L+   +ri+
  EFC39872.1 165 TSISEMKQLTSLNISGNRIGdegakLISEMKQLTLLNIADNRIC 208
                 23444445556666777777654444444555555555556665 PP

  == domain 3  score: 0.9 bits;  conditional E-value: 0.49
      bZIP_C 106 qrvasLe 112
                 ++ +sL+
  EFC39872.1 315 EQLTSLD 321
                 3333333 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 1.2
      bZIP_C 101 rtasLqrvasLe 112
                  ++++++ +sL+
  EFC39872.1 382 FISEMEQLTSLD 393
                 233333333333 PP

  == domain 5  score: -1.4 bits;  conditional E-value: 2.6
      bZIP_C  73 nglpdissvelqekadlanaavaagkmgrtasLqrvasL 111
                 n ++d ++                     ++++++ +sL
  EFC39872.1 421 NRIGDEGVK-------------------FISEMKQLTSL 440
                 333333333...................23333333333 PP

  == domain 6  score: 6.6 bits;  conditional E-value: 0.0086
      bZIP_C  54 dpkhyfnltstaddlqvlnnglpdissvelqekadlanaavaagkmg.....rtasLqrvasLehlqkrir 119
                 +  ++ + ++  + lq+ +n ++d ++ ++ e ++l + +++++ +g      ++++++ +sL+   +ri 
  EFC39872.1 474 EGVKFISEMKQLTLLQIYSNRIGDEGVKSISEMKQLTSLNISGNRIGdegvkSISEMKQLTSLNISNNRIG 544
                 5556666677777789999999999999999999999999999*999998888999999999999999995 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (559 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       390  (0.0217525); expected 358.6 (0.02)
Passed bias filter:                      167  (0.00931452); expected 358.6 (0.02)
Passed Vit filter:                        21  (0.00117129); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              10  [number of targets reported over threshold]
# CPU time: 0.75u 0.31s 00:00:01.06 Elapsed: 00:00:00.51
# Mc/sec: 3320.28
//
Query:       EFC39873.1  [L=1258]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    6.7e-52  176.3   0.1    7.2e-48  163.1   0.0    2.3  2  Pkinase_Tyr  Protein tyrosine kinase
    1.2e-44  152.7   0.1    2.5e-44  151.6   0.1    1.5  1  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
      0.026   14.4   0.0      0.042   13.8   0.0    1.2  1  APH          Phosphotransferase enzyme family


Domain annotation for each model (and alignments):
>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  163.1   0.0   1.2e-51   7.2e-48       2     230 ..     964    1195 ..     963    1215 .. 0.86
   2 !   11.2   0.0   2.7e-05      0.16     229     259 .]    1219    1249 ..    1198    1249 .. 0.88

  Alignments for each domain:
  == domain 1  score: 163.1 bits;  conditional E-value: 1.2e-51
                   EEEEEEEEESSEEEEEEEEETTTTSSEEEEEEEEESTTSSHHHHHHHHHHHHHHHTS-BTTB--EEEEEESSSSEEEEEE--TTEBHHHHHHHTCT CS
  Pkinase_Tyr    2 elgkklGeGafGkVvegtlkgekekkevkVavKtlkeeateeekeelleeakimkklkhpnivkllgvctkeepllivteyvkgGdLlkfLrkkek 97  
                   ++ kk+GeG  ++V+ gt++      ++kVa+K+lk+e +e+ ++++ +ea+i+++++hpn++ ++gvc+ +++ +ivtey+++G+L+kf+ ++++
   EFC39873.1  964 TIIKKIGEGGAANVYYGTWT------NIKVAIKSLKSEINEDFEQNFEREASILSNIRHPNVLTFYGVCLTDKSRYIVTEYMEKGTLEKFIYESRN 1053
                   7899****************......9****************************************************************99977 PP

                   TTSBH...HHHHHHHHHHHHHHHHHHHTT..EEEST-SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSGGGGS....-HHHHHHSEEEH CS
  Pkinase_Tyr   98 ekltl...kdllsfalqvAkGmeyLeskk..lvHrdlaarNvLlsenkvvkisDfGLardiekddeyvkkeeaklpvkWm....apEslkekkfts 184 
                   + +++   k++l +   +++Gm+yL++ k  ++Hrdl + N+Ll+e++  k+sDfGL + + ++  +++ ++a   + +m        +++k+  +
   EFC39873.1 1054 RGMNIellKTILTLLCGISNGMQYLHALKpaVIHRDLKSSNILLDERNNPKVSDFGLVKVLGTNTMQTQMTKAIGTIFFMesfmTDHPIDNKEAAT 1149
                   7777511256788999**********877669***************************9977766666666666665552222777788899*** PP

                   HHHHHHHHHHHHHHHTTSSGTTTTS.HHHHHHHHHHTTEES-BBTTS CS
  Pkinase_Tyr  185 ksDvWsfGvllwEiftlgespypgl.kneevleklkegkrlekpekc 230 
                   k Dv+sf++l+wE+f   +spy+++ ++ ++ + + +g+r + p ++
   EFC39873.1 1150 KLDVYSFSILMWELFF-RKSPYHHVkNTFKIPQLVCDGERPQIPFSV 1195
                   ***************9.89******5556777777****99988654 PP

  == domain 2  score: 11.2 bits;  conditional E-value: 2.7e-05
                   TSBHHHHHHHHHHT-SSGGGS--HHHHHHHH CS
  Pkinase_Tyr  229 kcpeelyelmkkcweedpeeRptfselvekl 259 
                   +c ++  +l+ kcw+++p eRp fs+++++l
   EFC39873.1 1219 QCIDRYFSLVVKCWNHNPLERPLFSNIRQEL 1249
                   7899999********************9986 PP

>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  151.6   0.1   4.1e-48   2.5e-44       3     260 ..     965    1247 ..     963    1249 .. 0.81

  Alignments for each domain:
  == domain 1  score: 151.6 bits;  conditional E-value: 4.1e-48
                  EEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHHHHHHHHHHHHHHHSCTTB--EEEEEEESSEEEEEEE--TTEBHHHHHH..HHSS--H CS
     Pkinase    3 kleklGeGsfGkVykaveketgkivAvKkikkekakkkkekkvlrEikilkklkhpnivrlyevfeekdelylvleyveggeladlle..rkgslse 97  
                   ++k+GeG+ ++Vy ++  +t+ +vA+K +k e +++  e+++ rE +il +++hpn++++y+v+ +++++y+v+ey+e+g+l++++   r++ ++ 
  EFC39873.1  965 IIKKIGEGGAANVYYGT--WTNIKVAIKSLKSEINED-FEQNFEREASILSNIRHPNVLTFYGVCLTDKSRYIVTEYMEKGTLEKFIYesRNRGMNI 1058
                  689**************..9**********9886665.667*********************************************99776666777 PP

                  HHHH...HHHHHHHHHHHHHHHTT..EE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCS...BCTTTSCGGGS-HHHH....TTSCBSHHHHHHH CS
     Pkinase   98 eeak...kiakqilegleylHskg..iiHrDlKpeNiLidekgelKitDFGlakelesssk...ltsfvgtseYlAPEvl....keneyskkvDvWs 182 
                  e +k    ++  i +g++ylH+ +  +iHrDlK++NiL+de+++ K++DFGl+k l +++    +t+ +gt  ++   +     +++e  +k Dv+s
  EFC39873.1 1059 ELLKtilTLLCGISNGMQYLHALKpaVIHRDLKSSNILLDERNNPKVSDFGLVKVLGTNTMqtqMTKAIGTIFFMESFMTdhpiDNKEAATKLDVYS 1155
                  76661114556899*******77667******************************998878889999999877655554444499999******** PP

                  HHHHHHHHHHSS-STTTSSHHHHHHHHHHT..HHHHHHHCT...SHH...HHHTTS...................-HHHHHHHHHHT-SSGCCSTTH CS
     Pkinase  183 lGvilyelltgkppfsgekgkekvekeldq..lekilkilg...etkeklpeasei...................seeakdllkkllkkdpkkRlta 255 
                    ++++el+++k p+++ k++ k+ + + +    +i   +g   e          i                    +   +l+ k+++ +p +R+ +
  EFC39873.1 1156 FSILMWELFFRKSPYHHVKNTFKIPQLVCDgeRPQIPFSVGnqeE----------IrewllesngesnsdvviqcIDRYFSLVVKCWNHNPLERPLF 1242
                  ****************88887766666655233333333333330..........2333333455666666776689999999**********9998 PP

                  HHHHT CS
     Pkinase  256 eellq 260 
                  +++ q
  EFC39873.1 1243 SNIRQ 1247
                  88765 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.0     7e-06     0.042     163     196 ..    1080    1111 ..    1051    1113 .. 0.84

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 7e-06
                  SS-EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH  163 elptvllHgDlhpgNllvdpddgrvtGviDfeda 196 
                  +l++ ++H+Dl++ N+l+d+++++   v Df+++
  EFC39873.1 1080 ALKPAVIHRDLKSSNILLDERNNPK--VSDFGLV 1111
                  57889**************999998..9999887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1258 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1125  (0.0627475); expected 358.6 (0.02)
Passed bias filter:                      538  (0.0300073); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.97u 0.30s 00:00:01.27 Elapsed: 00:00:00.51
# Mc/sec: 7492.52
//
Query:       EFC39874.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       999  (0.0557198); expected 358.6 (0.02)
Passed bias filter:                      606  (0.0338); expected 358.6 (0.02)
Passed Vit filter:                        52  (0.00290033); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.66u 0.33s 00:00:00.99 Elapsed: 00:00:00.54
# Mc/sec: 2849.90
//
Query:       EFC39875.1  [L=154]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    4.3e-18   65.9   1.0    5.2e-18   65.6   1.0    1.0  1  Cass2      Integron-associated effector binding protein
    2.2e-08   34.5   0.3    2.8e-08   34.2   0.3    1.1  1  GyrI-like  GyrI-like small molecule binding domain


Domain annotation for each model (and alignments):
>> Cass2  Integron-associated effector binding protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.6   1.0   5.8e-22   5.2e-18       8     148 ..      13     151 ..       9     152 .. 0.88

  Alignments for each domain:
  == domain 1  score: 65.6 bits;  conditional E-value: 5.8e-22
                 EEEEEEEEETTCCCCH.....HHHHHHHHHHHHHHHCTTSBSTEEEEEEEC-TT.-CCGEEEEEEEEE-TT.SSS-TT-EEEEE--EEEEEEEEESSST CS
       Cass2   8 ftvaGiryegskeeed..lnkeigklwreflekgrlkkikkdkrvfgiyhdyes.eenkfsyyagvevpsd.sevpeglvkkeiPggkYavftiegdfe 102
                 + + G+++++++++e      +ig+lw +f ++     + ++++++++y++yes  ++ +++y++++ ++   +++e + + +    +++vf+  g+++
  EFC39875.1  13 IQLSGVKCRTTNKDEMnpSTARIGQLWGQFFQQST---QPIQSKIYSVYTNYESdHNGAYDIYVATPSSESnRNLTETIQIPQENDEEFLVFSGSGKMP 108
                 6778999999999998788899**********993...3468************99********999999656667777777777789*********** PP

                 T-HHHHHHHHHHCHCC.HCTEEE-SSEEEEEESTTHHHTEEEEEEEE CS
       Cass2 103 edlaeaweaiygellp.nsnyerrggpdfEvykeepaekseielyIP 148
                 e   ++w+ i++ + + +  y r+ + dfE+y++++    ++ +yI+
  EFC39875.1 109 ETCINLWQSIWQYFDKhHVEYSRAFSLDFEEYDDKE----NVKIYIA 151
                 **************997799999999******9855....9999997 PP

>> GyrI-like  GyrI-like small molecule binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   34.2   0.3   3.1e-12   2.8e-08      13     155 .]      15     153 ..       8     153 .. 0.81

  Alignments for each domain:
  == domain 1  score: 34.2 bits;  conditional E-value: 3.1e-12
                 EEEEEEEEEHCCCHH.....HHHHHHHHHHHHHHHHCTT--SSEEEEEEEEE-STTCCCEEEEEEEECCCCC...CGBTTSEEEEE-SEEEEEEEEECE CS
   GyrI-like  13 vvgirhrgdyneegg.....ipklweelyawaseiklsnavspligvssdepeetedeelkydigvtveirv...egpeglefleipageyAvfrhkGp 103
                 + g++ r+++++e++     i++lw+++++++ +      +s+++ v+ +++    d+   ydi+v+++      + +e +++ +  + e++vf+  G 
  EFC39875.1  15 LSGVKCRTTNKDEMNpstarIGQLWGQFFQQSTQP----IQSKIYSVYTNYE---SDHNGAYDIYVATPSSEsnrNLTETIQIPQENDEEFLVFSGSGK 106
                 56899999999999996666666666666666555....569********95...7999999999999988866777777777777789********** PP

                 G.GGHHHHHHHHHHTHHHHTT-..EEEESEEEEEEECCCTSSCGCEEEEEEEEEC CS
   GyrI-like 104 y.ddlqatyaklygewlpesgy..errdgpsiEiYlsdprereeelkteiyipvk 155
                 + +++ + ++ ++  +++++    +r++  ++E Y+         ++++iyi +k
  EFC39875.1 107 MpETCINLWQSIWQ-YFDKHHVeySRAFSLDFEEYDDK-------ENVKIYIALK 153
                 **************.887776556***********886.......4578888775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (154 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       648  (0.0361426); expected 358.6 (0.02)
Passed bias filter:                      406  (0.0226449); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.53u 0.33s 00:00:00.86 Elapsed: 00:00:00.52
# Mc/sec: 895.31
//
Query:       EFC39876.1  [L=374]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.4e-51  173.5  22.8    7.5e-51  173.0  22.8    1.2  1  HlyIII    Haemolysin-III related
  ------ inclusion threshold ------
        1.5    8.2  12.4        2.3    7.6  12.4    1.2  1  SelP_N    Selenoprotein P, N terminal region


Domain annotation for each model (and alignments):
>> HlyIII  Haemolysin-III related
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  173.0  22.8   8.3e-55   7.5e-51       1     224 []     115     354 ..     115     354 .. 0.96

  Alignments for each domain:
  == domain 1  score: 173.0 bits;  conditional E-value: 8.3e-55
      HlyIII   1 fslhnEtlniwtHllgailfivlailllslaevken.skla................kvvvlvfllgallcllcSalyHtlsihseeklrkffaklDys 82 
                 f+++nEt+n wt +l a++f++++i ++++ e + + ++++                k +++v+ +++++ +++S +yH +s++se  + +++ ++D s
  EFC39876.1 115 FQINNETVNNWTAILSALVFFYFTIDVIFFWEPTLIgETKNgyssyfnhvvsenfleKSMFVVYCVSSIITFGASLFYHWFSCMSE-SAFHTLLRIDIS 212
                 899*****************9999999999999888633337889999999999999*****************************.99999******* PP

      HlyIII  83 gIslliagsylplilyalakapkagllylslilalgvlgiisklvplfsrpearplravlfillgllgvipllhlllvltqlgeaa.elalvllvlggv 180
                 +I+lli gsy p+++ya++++   g +y+s+i++l++ ++ + ++p+fsr+ +r +r+++f   +l+g++pl+h +++l+++++ a ++ l  ++++++
  EFC39876.1 213 SIALLIGGSYYPPLYYAFYCTQSVGVFYISTITILCLSCVAMFIIPRFSREDYRQFRVRVFGFTALYGLCPLVH-IIYLYGFDNDAlNNRLLGIMYMYL 310
                 **************************************************************************.999*****999************* PP

      HlyIII 181 lylvGavfYalrvPErlkpgkfdivghsHqiFHvfvvlgalfhy 224
                 +y +G++fY++++PErl+pgkfdi+ hsHq++H+fv  ++l+h+
  EFC39876.1 311 CYAAGVFFYSTKLPERLWPGKFDIFCHSHQFWHIFVFSATLLHF 354
                 ******************************************96 PP

>> SelP_N  Selenoprotein P, N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6  12.4   0.00025       2.3     170     214 ..      12      55 ..       2      77 .. 0.46

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.00025
      SelP_N 170 aaeekpaeaeektehehahshkqghkhhekhghhHkekeelsesq 214
                 ++++  +++ +  + +++ ++ + h+h+++h++hH+e++ + ++ 
  EFC39876.1  12 RTQQSIKTE-DIATTSTSPEQLKDHQHQHNHHQHHHEENMHAHEL 55 
                 222222222.33333333333355555555555555544443332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (374 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1652  (0.0921412); expected 358.6 (0.02)
Passed bias filter:                      676  (0.0377043); expected 358.6 (0.02)
Passed Vit filter:                        63  (0.00351386); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.49
# Mc/sec: 2288.29
//
Query:       EFC39877.1  [L=283]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.072   13.1   0.0        0.2   11.6   0.0    1.7  1  Slx4      Slx4 endonuclease


Domain annotation for each model (and alignments):
>> Slx4  Slx4 endonuclease
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.0   1.1e-05       0.2       6      25 ..      98     117 ..      94     136 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 1.1e-05
                 HHHHT-HHHHHHHHTT--EE CS
        Slx4   6 eaiksdpslhekILlYePIv 25 
                 e++k+dps+ ekIL Ye+I+
  EFC39877.1  98 EVLKQDPSFQEKILEYETIQ 117
                 6789***************6 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (283 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       981  (0.0547158); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.50u 0.33s 00:00:00.83 Elapsed: 00:00:00.50
# Mc/sec: 1712.87
//
Query:       EFC39878.1  [L=434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
      0.006   16.9   7.5      0.006   16.9   7.5    6.7  7  Alanine_zipper  Alanine-zipper, major outer membrane lipoprot
  ------ inclusion threshold ------
        3.2    8.3  27.2          8    7.1   0.2    6.3  6  HisKA_3         Histidine kinase
        5.6    7.4  55.6        2.6    8.5   8.7    6.0  6  DUF2564         Protein of unknown function (DUF2564)


Domain annotation for each model (and alignments):
>> Alanine_zipper  Alanine-zipper, major outer membrane lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.2      0.34     2e+03      42      69 .]      33      60 ..      20      61 .. 0.76
   2 ?   -7.0  17.9         3   1.8e+04       9      68 ..      66     130 ..      58     131 .. 0.53
   3 !    7.4  25.8   0.00097       5.8       8      65 ..     131     181 ..     125     196 .. 0.53
   4 ?    0.7   3.9      0.12   7.1e+02      27      51 ..     241     263 ..     222     264 .. 0.73
   5 ?   -0.4  22.6      0.25   1.5e+03      15      58 ..     255     298 ..     252     316 .. 0.58
   6 ?   -2.0   5.6      0.82   4.9e+03      24      53 ..     297     326 ..     292     344 .. 0.51
   7 !   16.9   7.5     1e-06     0.006       2      54 ..     354     406 ..     352     414 .. 0.80

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.34
  Alanine_zipper 42 eaaAeeAqkaAeeaneradrmFeksmrK 69
                    +a+A  A+k  +++ ++  ++++k  +K
      EFC39878.1 33 QAKAVPANKPKQQKGKKFGKLLKKGASK 60
                    7889999999999999999999996655 PP

  == domain 2  score: -7.0 bits;  conditional E-value: 3
  Alanine_zipper   9 kadqa.eqdaaaaksaadeAkskAde..AaarAenA..eaaAeeAqkaAeeaneradrmFeksmr 68 
                      a +a ++  +++k+a+++ k++A++  A+ rA  A  +++A++A+++  +++ +++r+   ++r
      EFC39878.1  66 AAKKAiKKSKKELKKATKKVKKAAKKnlAKWRALWAkyKRIAQRALRKFRRTQRKLKRARRSASR 130
                     22222022333444444444444443335555555577788888888887777777777665555 PP

  == domain 3  score: 7.4 bits;  conditional E-value: 0.00097
  Alanine_zipper   8 akadqaeqdaaaaksaadeAkskAdeAaarAenAeaaAeeAqkaAeeaneradrmFek 65 
                     +++ +++++a++ak++a++A++k ++A++++++A       +k+ + a+++a r ++k
      EFC39878.1 131 KTVRKLKKQAKKAKKTAKKAQKKVKKASRKVKKA-------KKQVKKAAKKAARKLQK 181
                     4444555555555555555555555555555555.......44444444444444433 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.12
  Alanine_zipper  27 AkskAdeAaarAenAeaaAeeAqka 51 
                      ks+A++A++ A   +++A++A+k+
      EFC39878.1 241 KKSAAKKAKKVAG--KKTAKKAKKQ 263
                     5788888888666..8899998875 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.25
  Alanine_zipper  15 qdaaaaksaadeAkskAdeAaarAenAeaaAeeAqkaAeeaner 58 
                     ++a++ak++ ++Ak++ ++A++ +++A++aA++ +k+A  + ++
      EFC39878.1 255 KTAKKAKKQVKKAKKAEKKAKKLVKQAKKAAKSGNKKAAKKIAK 298
                     45666666666666666666666666666666666655544333 PP

  == domain 6  score: -2.0 bits;  conditional E-value: 0.82
  Alanine_zipper  24 adeAkskAdeAaarAenAeaaAeeAqkaAe 53 
                     a++A   A++  + A++    A+ A ++A+
      EFC39878.1 297 AKKAIVNAKKSIEVAKKSVTVAKVAVEKAK 326
                     444444444333333333333333333332 PP

  == domain 7  score: 16.9 bits;  conditional E-value: 1e-06
  Alanine_zipper   2 qveelqakadqaeqdaaaaksaadeAkskAdeAaarAenAeaaAeeAqkaAee 54 
                     +++++q+k++ +++++++ak++ ++A++kA++  ++A++  ++A++ qk+A++
      EFC39878.1 354 EIKKIQKKVEVVKKTVKKAKKNVKKAQKKARKVVKKAKKVIKKAKKVQKQAKR 406
                     57888888999999999999999999999988888888888888888888876 PP

>> HisKA_3  Histidine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.1    0.0018        10      26      61 ..      66     101 ..      62     108 .. 0.90
   2 ?    5.8   2.9    0.0033        20      22      65 ..     119     163 ..     112     166 .. 0.83
   3 ?    1.7   0.6     0.061   3.7e+02      30      61 ..     171     202 ..     157     208 .. 0.53
   4 ?    0.7   0.5      0.13   7.6e+02      27      54 ..     260     279 ..     242     294 .. 0.49
   5 ?   -0.4   0.0      0.28   1.7e+03      37      60 ..     317     340 ..     296     354 .. 0.50
   6 ?    7.1   0.2    0.0013         8      31      62 ..     358     389 ..     345     410 .. 0.79

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0018
                 HHHHHTTT-HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
     HisKA_3  26 lakrllekdpekaaeqlreieelarealqevRrllh 61 
                 +ak++++k++++++++ ++++++a+++l+  R+l +
  EFC39878.1  66 AAKKAIKKSKKELKKATKKVKKAAKKNLAKWRALWA 101
                 799999**************************9876 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.0033
                 HHHHHHHHHT.TT-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHTT CS
     HisKA_3  22 lqlelakrll.ekdpekaaeqlreieelarealqevRrllhnLrp 65 
                  +l+ a+r++ +k   k+++q+++++++a++a++ v++++++ ++
  EFC39878.1 119 RKLKRARRSAsRKTVRKLKKQAKKAKKTAKKAQKKVKKASRKVKK 163
                 5788888888566666********************999988765 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.061
                 HTTT-HHHHHHHHHHHHHHHHHHHHHHHHHHH CS
     HisKA_3  30 llekdpekaaeqlreieelarealqevRrllh 61 
                 +++k++ k+++++++  +l++++++ + ++++
  EFC39878.1 171 AAKKAARKLQKKAARKLKLSKTSIKKLNATVK 202
                 22333335555555555555555555555554 PP

  == domain 4  score: 0.7 bits;  conditional E-value: 0.13
                 HHHHTTT-HHHHHHHHHHHHHHHHHHHH CS
     HisKA_3  27 akrllekdpekaaeqlreieelarealq 54 
                 ak+++        ++++++e+ a++ ++
  EFC39878.1 260 AKKQV--------KKAKKAEKKAKKLVK 279
                 22222........222222222222222 PP

  == domain 5  score: -0.4 bits;  conditional E-value: 0.28
                 HHHHHHHHHHHHHHHHHHHHHHHH CS
     HisKA_3  37 kaaeqlreieelarealqevRrll 60 
                  a+ +++++++   + ++ +++l+
  EFC39878.1 317 VAKVAVEKAKQVFTTIVNKLKELV 340
                 333333333333333333333333 PP

  == domain 6  score: 7.1 bits;  conditional E-value: 0.0013
                 TTT-HHHHHHHHHHHHHHHHHHHHHHHHHHHH CS
     HisKA_3  31 lekdpekaaeqlreieelarealqevRrllhn 62 
                 ++k+ e ++++++++++++++a++ +R+++++
  EFC39878.1 358 IQKKVEVVKKTVKKAKKNVKKAQKKARKVVKK 389
                 56667778888888888888888888888765 PP

>> DUF2564  Protein of unknown function (DUF2564)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   1.0   0.00079       4.7      27      57 ..      59      90 ..      55     105 .. 0.74
   2 ?    2.5   5.3     0.031   1.9e+02      23      48 ..     146     171 ..     108     173 .. 0.63
   3 ?    3.2   7.7      0.02   1.2e+02      23      54 ..     146     177 ..     131     199 .. 0.82
   4 ?    8.5   8.7   0.00043       2.6      12      53 ..     245     286 ..     241     292 .. 0.90
   5 ?    4.8   1.2    0.0062        37      27      65 ..     297     327 ..     289     348 .. 0.45
   6 ?    5.2   6.7    0.0048        28       4      54 ..     354     403 ..     351     427 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00079
     DUF2564 27 dpdqle.sAtqAiedAreqlssaeehatgvde 57
                +++q++ +A++Ai++ +++l++a+++  +  +
  EFC39878.1 59 SKKQIKkAAKKAIKKSKKELKKATKKVKKAAK 90
                56677515789**********99987766555 PP

  == domain 2  score: 2.5 bits;  conditional E-value: 0.031
     DUF2564  23 TmsmdpdqlesAtqAiedAreqlssa 48 
                 T ++ ++ +++A + +++A++q ++a
  EFC39878.1 146 TAKKAQKKVKKASRKVKKAKKQVKKA 171
                 44455555555555555555555555 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.02
     DUF2564  23 TmsmdpdqlesAtqAiedAreqlssaeehatg 54 
                 T ++ ++ +++A + +++A++q ++a+++a+ 
  EFC39878.1 146 TAKKAQKKVKKASRKVKKAKKQVKKAAKKAAR 177
                 7788899999*************999998864 PP

  == domain 4  score: 8.5 bits;  conditional E-value: 0.00043
     DUF2564  12 vetAqkmvGqATmsmdpdqlesAtqAiedAreqlssaeehat 53 
                  + A+k+ G+ T ++ ++q+++A++A ++A++  ++a++ a 
  EFC39878.1 245 AKKAKKVAGKKTAKKAKKQVKKAKKAEKKAKKLVKQAKKAAK 286
                 5789***************************99999998775 PP

  == domain 5  score: 4.8 bits;  conditional E-value: 0.0062
     DUF2564  27 dpdqlesAtqAiedAreqlssaeehatgvdeeFleeseq 65 
                  ++ + +A+++ie A++  + a+          +e+ +q
  EFC39878.1 297 AKKAIVNAKKSIEVAKKSVTVAK--------VAVEKAKQ 327
                 33344444444444444433333........22222222 PP

  == domain 6  score: 5.2 bits;  conditional E-value: 0.0048
     DUF2564   4 dlkqvelavetAqkmvGqATmsmdpdqlesAtqAiedAreqlssaeehatg 54 
                 ++k+++  ve  +k+v +A ++  + q ++A + +++A++ +++a++++ +
  EFC39878.1 354 EIKKIQKKVEVVKKTVKKAKKNVKKAQ-KKARKVVKKAKKVIKKAKKVQKQ 403
                 677777777777777777777776665.66777777777777777777653 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      6325  (0.35278); expected 358.6 (0.02)
Passed bias filter:                     1020  (0.0568911); expected 358.6 (0.02)
Passed Vit filter:                       703  (0.0392102); expected 17.9 (0.001)
Passed Fwd filter:                       259  (0.0144459); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 4.09u 0.50s 00:00:04.59 Elapsed: 00:00:00.92
# Mc/sec: 1418.98
//
Query:       EFC39879.1  [L=389]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
  ------ inclusion threshold ------
        1.9    7.1   7.4       0.17   10.6   2.9    1.5  2  Presenilin  Presenilin


Domain annotation for each model (and alignments):
>> Presenilin  Presenilin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   2.9   9.3e-06      0.17     235     337 ..      46     169 ..      10     193 .. 0.40
   2 ?   -3.0   0.1      0.13   2.3e+03     237     244 ..     372     379 ..     340     388 .. 0.53

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 9.3e-06
  Presenilin 235 seeeeeaekkkeeasesskeeeseeesseksaqsse...................seeeseeesseaessaeesseekeseessesseeeeeeeeeeee 314
                 s++e+++++++++++++s++ +s++e+        +                   ++e+ ee++ e++ s+ee++ee+  ++++++ e  ++++     
  EFC39879.1  46 SDKENTSDNESTRTTRTSETLHSSWEND-------TlselsmnsiltkqteasdnEDEDLEEDEMETNGSEEETEEEEVIQKKRRHGEVVSKSK----- 132
                 1111111111111111111111111111.......01112222233322222222111111111111111111111111111111111111122..... PP

  Presenilin 315 ses.......ee....rgvkLGLGD..FiFY...SvLvg 337
                   +       +e    + + L LG   Fi Y   SvL+g
  EFC39879.1 133 --RiktegetNEhhipSHLLLTLGQtlFIPYagdSVLIG 169
                 ..1222222222222235556666522444555556665 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 0.13
  Presenilin 237 eeeeaekk 244
                 +++++++k
  EFC39879.1 372 SKKASKEK 379
                 11111111 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (389 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2020  (0.112667); expected 358.6 (0.02)
Passed bias filter:                      442  (0.0246528); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.29s 00:00:00.86 Elapsed: 00:00:00.46
# Mc/sec: 2527.78
//
Query:       EFC39880.1  [L=260]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (260 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       576  (0.0321267); expected 358.6 (0.02)
Passed bias filter:                      405  (0.0225891); expected 358.6 (0.02)
Passed Vit filter:                        25  (0.00139439); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.53u 0.28s 00:00:00.81 Elapsed: 00:00:00.48
# Mc/sec: 1634.24
//
Query:       EFC39881.1  [L=290]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    7.9e-17   61.4   7.2    5.6e-16   58.6   7.2    2.4  1  DUF4498   Domain of unknown function (DUF4498)
  ------ inclusion threshold ------
      0.025   15.0   0.1       0.11   13.0   0.1    2.1  2  CdiI_4    CDI immunity protein


Domain annotation for each model (and alignments):
>> DUF4498  Domain of unknown function (DUF4498)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.6   7.2   6.2e-20   5.6e-16      16     246 .]      21     288 ..      13     288 .. 0.66

  Alignments for each domain:
  == domain 1  score: 58.6 bits;  conditional E-value: 6.2e-20
     DUF4498  16 evkelLlkWslkg.rikvqafsfdkkfqpy........nkeeflldffkdpeVasal...klleksgawlalg..sevskv.eveevpctvvsmsfFdk 99 
                 + +e L+kW+l   +  +++f +d +++++        +ke +l++ +++++  ++l    l++ +++++  g  ++ ++v +v +++ +  +m++ ++
  EFC39881.1  21 DLREHLEKWDLGTeSTFYESFYVDLDMNQHdealvnteSKELLLKRALANSDQIKELaneYLNRLKERFICCGalHQLDTVqDVSPMNIKLADMTLIQR 119
                 566677777775413444555555444332011111113344445555555544555443233333333333300233344257888888889999887 PP

     DUF4498 100 ..llseg.ivresgsivkcldevve.dftisdeLrkvllded..................seeyelfseedr....eeflfrlfkhlvlGGelcQyede 172
                   l++e+ +  +s + +kclde+++ ++++sde rk++                       ++y l+ +++     +e+l ++   lv+GG++ Qyed+
  EFC39881.1 120 efLTNESlLYLKSLNTRKCLDEQIDsEMYVSDEYRKAMAYMLwaegctyynedtfiencnFQQYGLVEDSWTnicaRELLLHIHARLVIGGKFGQYEDN 218
                 656777766678889********9857********986544344479999*******99999999998888533337********************** PP

     DUF4498 173 lqpYlettkslYkdlvsvqk......dpetkkisvtstvykvkaldekgealypsekeeeqnfaylivdplkrhvtvlyh 246
                 l+pY + tk lYk+ vsvqk      +++++  s++s++yk   +          ++  +++   liv p+ ++vt++ h
  EFC39881.1 219 LMPYFNNTKLLYKNIVSVQKvssvdsNQSSQGFSIASKAYKCPVT----------NDLVDKSYFLLIVHPIDKKVTIMLH 288
                 ********************4444433444445555555554444..........2233667778889999999998876 PP

>> CdiI_4  CDI immunity protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.1   1.2e-05      0.11      22      75 ..     143     197 ..     126     204 .. 0.82
   2 ?   -1.6   0.0      0.43   3.8e+03      10      27 ..     264     281 ..     227     287 .. 0.70

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 1.2e-05
      CdiI_4  22 l.enlvkkegfalegtycifpdenspdeeeyF.egVeFtvgypvdekdvidiVsek 75 
                 + +++   + +++  +y+ +++ ++ ++e+ F e+ +F+  y++ e+++++i   +
  EFC39881.1 143 IdSEMYVSDEYRKAMAYMLWAEGCTYYNEDTFiENCNFQQ-YGLVEDSWTNICARE 197
                 5566666778889999**********************98.********9987655 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.43
      CdiI_4  10 svlyndgvFlealenlvk 27 
                 ++l+++ +Fl +++ + k
  EFC39881.1 264 NDLVDKSYFLLIVHPIDK 281
                 455666666666655554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (290 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       636  (0.0354733); expected 358.6 (0.02)
Passed bias filter:                      357  (0.0199119); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.51u 0.28s 00:00:00.79 Elapsed: 00:00:00.46
# Mc/sec: 1901.55
//
Query:       EFC39882.1  [L=218]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      3e-11   43.1   0.0    1.1e-10   41.3   0.0    1.8  2  RWP-RK    RWP-RK domain


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.3   0.0     6e-15   1.1e-10       1      46 [.      60     105 ..      60     107 .. 0.97
   2 ?   -1.2   0.0      0.11   2.1e+03      14      32 ..     180     210 ..     178     214 .. 0.78

  Alignments for each domain:
  == domain 1  score: 41.3 bits;  conditional E-value: 6e-15
      RWP-RK   1 nltleelqqyFslplkeAAksLgvskttLKricRelgIsRWPyRki 46 
                 ++t+e++++yF+ p   AA+ L+vs +tLKr+  e+   RWPy k+
  EFC39882.1  60 TITKEDMSRYFNAPQVMAARLLNVSVSTLKRRFYEMYEGRWPYQKM 105
                 69******************************************97 PP

  == domain 2  score: -1.2 bits;  conditional E-value: 0.11
      RWP-RK  14 plkeAAksLg............vskttLKri 32 
                 +l+++ k+Lg            v+ t +K+ 
  EFC39882.1 180 NLENVTKDLGklkggsrqkyslVGVTGVKKT 210
                 6778888888888888888888999999886 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (218 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       885  (0.0493614); expected 358.6 (0.02)
Passed bias filter:                      391  (0.0218082); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.41u 0.24s 00:00:00.64 Elapsed: 00:00:00.38
# Mc/sec: 1719.37
//
Query:       EFC39883.1  [L=514]
Description: nicotinamide-nucleotide adenylyltransferase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    0.00062   20.0   0.0       0.39   10.9   0.0    2.9  2  CTP_transf_like  Cytidylyltransferase-like
  ------ inclusion threshold ------
       0.05   13.9   0.4       0.92    9.8   0.1    2.6  2  DUF4263          Domain of unknown function (DUF4263)
       0.15   12.5   0.0       0.36   11.3   0.0    1.7  1  FumaraseC_C      Fumarase C C-terminus


Domain annotation for each model (and alignments):
>> CTP_transf_like  Cytidylyltransferase-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.0   0.0    0.0022        13       4      37 ..     254     289 ..     251     301 .. 0.73
   2 !   10.9   0.0   6.6e-05      0.39      43     142 ..     330     478 ..     315     479 .. 0.73

  Alignments for each domain:
  == domain 1  score: 6.0 bits;  conditional E-value: 0.0022
                      E--TT--HHHHHHHHHHHHHSSES..EEEEEESSTH CS
  CTP_transf_like   4 GtFDpiHlGHlrlleqakklleed..livgvpsdep 37 
                      G  +p+H++H + +e+ak+ +e+   l+ +v s+++
       EFC39883.1 254 GAINPPHKMHQQGFEVAKEFVENYqtLMKAVESKPK 289
                      6779***************99996444444444443 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 6.6e-05
                      SCSSTHHHHHHHHHHHTTCTTEEEEEEESEHH.................................HHHHHTTTT.....EEEEEEEHHHHHHHH CS
  CTP_transf_like  43 kplasaeeRlemlelakevdevisvdpweltr.................................evlkklkpd.....klylvigadvledfs 98 
                        l +a eRl m+ l +++d++    pwe+ +                                   + +   d      ++  +gad++  + 
       EFC39883.1 330 VRLYTATERLTMCALQTQDDPFTCEYPWESCQpkfisfsqvgntcstilrsaecpismlmpknpnTNQYQ---DscsylRVCYTCGADLILRAG 420
                      567899**************************************************99999975533333...234478888888888888853 PP

                      CHH.................HHHHHHHHHHHEEEEEEHTTCEEE..EEEECCTTTCSHHHHHH CS
  CTP_transf_like  99 ewk.................eleeilgnvklvvvsrpekqanvl..lkaekrtngiSstkire 142
                        +                 ++ee++++ + +  + p     v+   +++ ++n  Sst++r+
       EFC39883.1 421 LRRfdyfedmlslvvgrhgvNVEEVMKSINEAHNNMP-----VFyvEIENMQENALSSTEVRT 478
                      3333333334455555555555555555555555555.....44355677788999****995 PP

>> DUF4263  Domain of unknown function (DUF4263)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8   0.1   0.00015      0.92      42      94 ..      52     104 ..       6     124 .. 0.81
   2 ?    1.1   0.0     0.071   4.2e+02      43      85 ..     455     500 ..     426     507 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00015
     DUF4263  42 l..ngnivlvEikkpdknlltkekkkgniapseelsgaisQikkylllldknkek 94 
                 +  n +++l+E++k+  nl+  ++++ ++++++  +g+  Q+++ l +l++  e+
  EFC39883.1  52 RdfNESFDLIELEKHVRNLIS-NNNH-VMVITSYSKGKGCQVLELLQRLKRSNEE 104
                 334899**************8.4555.799***9999999**9999999865554 PP

  == domain 2  score: 1.1 bits;  conditional E-value: 0.071
     DUF4263  43 ngnivlvEikkpdknlltkekkk...gniapseelsgaisQikkyl 85 
                 n+ ++ vEi++ ++n l  ++ +   +nia +e++++  ++++k l
  EFC39883.1 455 NMPVFYVEIENMQENALSSTEVRtclENIAKNEDVKNSRMRLEKVL 500
                 5566779**********97777799999999999999999988876 PP

>> FumaraseC_C  Fumarase C C-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0     6e-05      0.36      14      53 ..     266     305 ..     263     306 .. 0.91

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 6e-05
                  HHHHHHHHHHHT--HHHHHHHTT-.-HHHHHHHT-HHHHH CS
  FumaraseC_C  14 AakIAkeAlkegktlreavlelgllteeeldelldpekMt 53 
                  + ++Ake +++ +tl  av  +  l +e l+++l+p k +
   EFC39883.1 266 GFEVAKEFVENYQTLMKAVESKPKLNRELLQKILRPIKVV 305
                  569*********************************8866 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (514 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1119  (0.0624129); expected 358.6 (0.02)
Passed bias filter:                      640  (0.0356964); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.67u 0.30s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 3074.76
//
Query:       EFC39884.1  [L=573]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    9.4e-11   41.5   0.0    2.2e-10   40.4   0.0    1.6  1  MTS              Methyltransferase small domain
    2.1e-06   27.4   0.1    4.6e-06   26.2   0.1    1.5  1  PrmA             Ribosomal protein L11 methyltransferase (Prm
    0.00025   20.4   0.4    0.00053   19.3   0.4    1.5  1  N6_Mtase         N-6 DNA Methylase
    0.00042   20.1   0.1     0.0012   18.6   0.1    1.7  1  Methyltransf_16  Lysine methyltransferase
    0.00073   20.2   0.0     0.0019   18.8   0.0    1.8  1  Methyltransf_25  Methyltransferase domain
     0.0011   18.8   0.0     0.0022   17.8   0.0    1.4  1  Methyltransf_23  Methyltransferase domain
     0.0013   18.5   0.1      0.003   17.4   0.1    1.7  1  Methyltransf_31  Methyltransferase domain
  ------ inclusion threshold ------
      0.012   16.3   0.0      0.054   14.2   0.0    2.2  1  Methyltransf_12  Methyltransferase domain


Domain annotation for each model (and alignments):
>> MTS  Methyltransferase small domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   40.4   0.0   9.7e-14   2.2e-10      26     117 ..     330     438 ..     298     444 .. 0.73

  Alignments for each domain:
  == domain 1  score: 40.4 bits;  conditional E-value: 9.7e-14
                 HCHCC..TCSEEEEET-TTSHHHHHHHHH....TTC.EEEEEESBHHHHHHHHHHHHHTTGC.....EEEEE-STTTTST......TS-EEEEEE---S CS
         MTS  26 tlpke..lsgkvlDlGcGaGvlgaalake....speaevtlvdvdarAlesakenleankle.....vevvasdvleeve......ekkfdlivsNPPf 107
                 +l+++   + ++lDlG+G Gv ++ + k      +++e+++vd++  Ale++k n+e+n  +     +++v+ d++++ +       ++++li++NPP 
  EFC39884.1 330 KLTNSkkPKLEILDLGAGSGVFSIYVSKLisenVSDLEIKFVDINPWALECSKFNFENNFKScnnisGKYVQVDLTSDNNlneskdSNSINLILCNPPW 428
                 44444345667*************98876111155678******************9986555566667777666654322111126899********9 PP

                 TTTCHCHHHH CS
         MTS 108 hagkatelav 117
                  + ++++++ 
  EFC39884.1 429 ISIEKKDYEH 438
                 8877766655 PP

>> PrmA  Ribosomal protein L11 methyltransferase (PrmA)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   26.2   0.1     2e-09   4.6e-06     156     233 ..     332     425 ..     325     426 .. 0.68

  Alignments for each domain:
  == domain 1  score: 26.2 bits;  conditional E-value: 2e-09
        PrmA 156 eklvkegeevlDvGtGSGiLaiaaakLgakkv.....vavDiDevAvkvakeNaelN.....kvea.klevalseell..k...eekadvivaN 233
                  +  k++ e+lD+G+GSG+ +i ++kL  ++v       vDi++ A++ +k N+e N     +++   ++v l+++    +   ++++++i++N
  EFC39884.1 332 TNSKKPKLEILDLGAGSGVFSIYVSKLISENVsdleiKFVDINPWALECSKFNFENNfkscnNISGkYVQVDLTSDNNlnEskdSNSINLILCN 425
                 556777889******************9887611111579**************9997755544443344433322222212235667777777 PP

>> N6_Mtase  N-6 DNA Methylase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.4   2.4e-07   0.00053      32     190 ..     321     492 ..     313     534 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 2.4e-07
    N6_Mtase  32 revsklivell..epksgesvyDpacGsggllvqaekvlkeedgktkelsiyGqeknettyrLakmNl.....llhgieykkvk..irlgdtlekpkfe 121
                 ++v +li + l   +k++  ++D  +Gsg + + ++k +   +++ ++l+i  +++n+ + + +k N+        +i  k v+   + ++ l++ k  
  EFC39884.1 321 QSVNELINSKLtnSKKPKLEILDLGAGSGVFSIYVSKLI---SENVSDLEIKFVDINPWALECSKFNFennfkSCNNISGKYVQvdLTSDNNLNESK-- 414
                 56777777666665566667*****************99...5888888999999999999999999844433467888887772244455555554.. PP

    N6_Mtase 122 kdkkfdvvvaNppfnqkewkektlekderfrea......vapksnadlafl...lhiieslkpkGraavvlangvLfr 190
                 + ++++ ++ Npp+ + e k+ + +++er + +             d+ fl   lh++++ ++k + +++l ++v   
  EFC39884.1 415 DSNSINLILCNPPWISIEKKDYEHIQNERMKFGsfkntiDLSIFDTDYEFLdqfLHLLQKSQNKQTFGMLLVSNVGHL 492
                 469***********9988888889999988888744423112235667776433677777788888888777776555 PP

>> Methyltransf_16  Lysine methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.6   0.1   5.3e-07    0.0012      36     125 ..     327     423 ..     314     425 .. 0.81

  Alignments for each domain:
  == domain 1  score: 18.6 bits;  conditional E-value: 5.3e-07
  Methyltransf_16  36 lakelganelsklsvlELGsGtGlvGlavael....lpeakviltDlee.llellkknielnkn...alkskvkvevLdWgeeleedllekeev 121
                      ++++l +++  kl++l+LG+G+G++ + v +l    ++++++   D++  +le+ k n e n +   +++ k +   L+ +++l ++  +++++
       EFC39884.1 327 INSKLTNSKKPKLEILDLGAGSGVFSIYVSKLisenVSDLEIKFVDINPwALECSKFNFENNFKscnNISGKYVQVDLTSDNNL-NESKDSNSI 419
                      4444777888899*****************999986699********9989********9986555567777777789999999.666688889 PP

  Methyltransf_16 122 Dlil 125
                      +lil
       EFC39884.1 420 NLIL 423
                      9998 PP

>> Methyltransf_25  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   8.6e-07    0.0019       1      84 [.     341     438 ..     341     445 .. 0.75

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 8.6e-07
                      EEEET-TTSHHHHHHHCTS..T..SSEEEEEESSHHHHHHHHHHHHH.....TTTTEEEEESBC...CGBS..SSTTTEEEEEEEST.GGGSSH CS
  Methyltransf_25   1 vLdlGcGtGrltlalakrl..g..kakvtgvDiseemleaareraee.....eglnvefvqgda...edlp..fedgsfDlvvssga.lhhlsd 79 
                      +LdlG+G+G ++++++k +  +  + ++  vDi++ +le  + ++e+     ++++ ++vq d+   ++l+   +++s++l++++   +  +++
       EFC39884.1 341 ILDLGAGSGVFSIYVSKLIseNvsDLEIKFVDINPWALECSKFNFENnfkscNNISGKYVQVDLtsdNNLNesKDSNSINLILCN-PpWISIEK 433
                      8*************99998763569***************997776655445555888999999543335433588899999995.43666676 PP

                      HHHHH CS
  Methyltransf_25  80 edlek 84 
                      +d+e+
       EFC39884.1 434 KDYEH 438
                      66665 PP

>> Methyltransf_23  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   9.8e-07    0.0022      18      88 ..     332     424 ..     312     439 .. 0.63

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 9.8e-07
  Methyltransf_23  18 pk.lraggrvLdiGcGtGillevl....rengf..svtgvDlspeaveiae.kakkaqkdqfdeq..............eaaepqgkfdlIvl 88 
                      ++ ++++ ++Ld+G+G+G ++ +     +en+   ++ +vD++p+a e  + ++ +++k++ + +              ++++++++++lI +
       EFC39884.1 332 TNsKKPKLEILDLGAGSGVFSIYVskliSENVSdlEIKFVDINPWALECSKfNFENNFKSCNNISgkyvqvdltsdnnlNESKDSNSINLILC 424
                      23256666***********9888844445576666899*******999876744444444443322222233322222334444556666655 PP

>> Methyltransf_31  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.1   1.3e-06     0.003       3      82 ..     337     426 ..     335     519 .. 0.76

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.3e-06
  Methyltransf_31   3 kglrvlDlGCGtGeltfelae...elgpkaevvGiDiseeaielArenaqklgld..nve..Feqgdieeleklled....ekfDlilsne 82 
                       +l++lDlG+G+G +++   +   e  ++ e+  +Di++ a+e ++ n ++++ +  n++    q d ++ ++l ++    ++++lil+n 
       EFC39884.1 337 PKLEILDLGAGSGVFSIYVSKlisENVSDLEIKFVDINPWALECSKFNFENNFKScnNISgkYVQVDLTSDNNL-NEskdsNSINLILCNP 426
                      6789***********9988876657778999*****************99877666655311445555552222.2223578888888884 PP

>> Methyltransf_12  Methyltransferase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   2.4e-05     0.054       1      42 [.     342     387 ..     342     426 .. 0.69

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 2.4e-05
  Methyltransf_12   1 LeiGcGtGsllrallekl....pdieytgvDispsaiedakeklak 42 
                      L++G+G+G ++ ++ + +    +d+e+ +vDi+p a+e  k  +  
       EFC39884.1 342 LDLGAGSGVFSIYVSKLIsenvSDLEIKFVDINPWALECSKFNFEN 387
                      8************************************333222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (573 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       866  (0.0483016); expected 358.6 (0.02)
Passed bias filter:                      348  (0.0194099); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               8  [number of targets reported over threshold]
# CPU time: 0.58u 0.28s 00:00:00.86 Elapsed: 00:00:00.45
# Mc/sec: 3814.93
//
Query:       EFC39885.1  [L=299]
Description: hypothetical protein NAEGRDRAFT_59183 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    9.3e-39  133.4   1.6    1.7e-38  132.5   1.6    1.5  1  Maf1      Maf1 regulator
  ------ inclusion threshold ------
      0.034   13.9   0.2       0.17   11.7   0.0    2.0  2  YfkB      YfkB-like domain
       0.19   12.1   1.9        2.4    8.6   0.0    2.6  2  DUF3873   Domain of unknown function, B. Theta Gene descripti


Domain annotation for each model (and alignments):
>> Maf1  Maf1 regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  132.5   1.6   2.9e-42   1.7e-38       2     174 .]      27     242 ..      26     242 .. 0.80

  Alignments for each domain:
  == domain 1  score: 132.5 bits;  conditional E-value: 2.9e-42
        Maf1   2 egrlelYsckaagsdkklykkiekeleselessskeslsls.....................aaseslssssPfg........................ 55 
                 +g++e +sck++++d+kl k+ie++  ++ ++s ++sl +s                     +           +                        
  EFC39885.1  27 YGKIEVFSCKQTSQDRKLTKEIESRRRTSSNASLSSSLPTStngtrlstlsqsvqtqqmqipT-----------Kattvahhqvdvvsppalsppcfyd 114
                 689**********************99888887777777778898988888666555555550...........2444555555555555567777777 PP

        Maf1  56 ........plsdkssrktlayLiatLnasfpdYDFsslrsseFkkekslksvinnidstLsslveekyeelreklWklideeidlkdCdiYsYkpdeds 146
                         p+  +++r+t++ Li+tLn s+pdYDF +++++ F+++ +l+  i+ni+++L +++e+++    ++lW+ ++e idl++C++YsY pd++ 
  EFC39885.1 115 ltsqfnddPF-GNEKRQTYIDLISTLNNSYPDYDFRHVKPEFFTQV-TLQDSIQNINNSLHEVYENEQ---FSSLWTNVNEIIDLNHCEVYSYLPDQNL 208
                 7776666444.789******************************99.***************766654...579**********************986 PP

        Maf1 147 d.pfkee.....galwsfnYFffnkklKrvlfls 174
                 d p+ +      + lws nYFf n+ lKr++f++
  EFC39885.1 209 DdPMADPlslggSKLWSWNYFFVNRPLKRLVFFT 242
                 558854422223689*****************95 PP

>> YfkB  YfkB-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   0.0   2.9e-05      0.17      24      63 ..      14      53 ..       7      60 .. 0.89
   2 ?   -0.8   0.1      0.19   1.2e+03      93     124 ..     162     192 ..     155     203 .. 0.68

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 2.9e-05
        YfkB 24 klldvrdedvwmlfGtlPfyacseeeedrellkrlaeekn 63
                 lld  d  +  l+G + +++c+++++dr+l+k++++ + 
  EFC39885.1 14 CLLDGYDLGITYLYGKIEVFSCKQTSQDRKLTKEIESRRR 53
                58999999999***********************988764 PP

  == domain 2  score: -0.8 bits;  conditional E-value: 0.19
        YfkB  93 eealgnikeekledvfekwkesklakslnchc 124
                 +++++ni+ ++l++v+e+ + s+l +++n   
  EFC39885.1 162 QDSIQNIN-NSLHEVYENEQFSSLWTNVNEII 192
                 45677775.68999999888777777776544 PP

>> DUF3873  Domain of unknown function, B. Theta Gene description (DUF3873)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.0   0.00041       2.4      15      49 ..     125     159 ..     122     170 .. 0.90
   2 ?    1.8   0.7     0.053   3.2e+02      26      45 ..     273     292 ..     260     295 .. 0.76

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.00041
     DUF3873  15 GeEkYekfqlgarrkrikyyqYDYrhtdgeLFSvv 49 
                 G+Ek +++   +     +y  YD+rh   e F  v
  EFC39885.1 125 GNEKRQTYIDLISTLNNSYPDYDFRHVKPEFFTQV 159
                 889999999999999999**************877 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.053
     DUF3873  26 arrkrikyyqYDYrhtdgeL 45 
                 +   +   +++DY + d e+
  EFC39885.1 273 YSNTKNANVHFDYNESDSEM 292
                 555667789********997 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (299 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       965  (0.0538234); expected 358.6 (0.02)
Passed bias filter:                      515  (0.0287244); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.55u 0.27s 00:00:00.82 Elapsed: 00:00:00.45
# Mc/sec: 1977.26
//
Query:       EFC39886.1  [L=766]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    0.00061   20.0   0.2     0.0023   18.2   0.1    2.1  2  Invasin_D3  Invasin, domain 3
  ------ inclusion threshold ------
        0.1   13.4   0.1        0.3   11.9   0.0    1.8  2  Filamin     Filamin/ABP280 repeat


Domain annotation for each model (and alignments):
>> Invasin_D3  Invasin, domain 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.4   0.0       1.5   1.3e+04      25      44 ..     102     122 ..     100     135 .. 0.63
   2 !   18.2   0.1   2.6e-07    0.0023      38      86 ..     267     314 ..     253     321 .. 0.77

  Alignments for each domain:
  == domain 1  score: -3.4 bits;  conditional E-value: 1.5
  Invasin_D3  25 tvtlkDangnpvsg.ltvtfs 44 
                  v++ D++g  ++  ++ ++ 
  EFC39886.1 102 RVQVLDQHGTDITSmASFVVD 122
                 688999999986652444444 PP

  == domain 2  score: 18.2 bits;  conditional E-value: 2.6e-07
  Invasin_D3  38 gltvtfsttsagtlsavtdngdGtytatLtattagtatitptvnGvaia 86 
                 g++ ++++ ++g l++   ++dG+y+a L a++ag + it++v+Gv+ +
  EFC39886.1 267 GQETSINMLDNGLLGDR-MENDGIYSAALNAQEAGDYVITVSVKGVIKG 314
                 55555554456766764.5667***********************6544 PP

>> Filamin  Filamin/ABP280 repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.1   0.0       1.6   1.4e+04      51      56 ..      84      89 ..      50     129 .. 0.50
   2 ?   11.9   0.0   3.3e-05       0.3      45      94 ..     259     310 ..     173     320 .. 0.86

  Alignments for each domain:
  == domain 1  score: -3.1 bits;  conditional E-value: 1.6
                ESSTS. CS
     Filamin 51 gsphga 56
                 s+++ 
  EFC39886.1 84 DSSEQV 89
                333222 PP

  == domain 2  score: 11.9 bits;  conditional E-value: 3.3e-05
                 EEEE..ESSTS.....EEEEEEEE-S........SSEEEEEE--SSSCEEEEEEEETT CS
     Filamin  45 qvrivtgsphgaatkssvkievvdne........dgtytvsYtpeepgtyrvsvkldg 94 
                 q++i   sp+g+    ++ i++ dn+        dg y +  +++e+g+y ++v+++g
  EFC39886.1 259 QMEI--LSPSGQ----ETSINMLDNGllgdrmenDGIYSAALNAQEAGDYVITVSVKG 310
                 4555..888888....889999999999999999*********************998 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (766 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       514  (0.0286686); expected 358.6 (0.02)
Passed bias filter:                      387  (0.0215851); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.69u 0.31s 00:00:01.00 Elapsed: 00:00:00.50
# Mc/sec: 4580.15
//
Query:       EFC39887.1  [L=693]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
  ------ inclusion threshold ------
      0.037   15.1   0.5         27    5.9   0.0    3.9  4  RNase_J_C  Ribonuclease J C-terminal domain


Domain annotation for each model (and alignments):
>> RNase_J_C  Ribonuclease J C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0    0.0015        27      41      73 .]      15      47 ..       2      47 .. 0.80
   2 ?    1.9   0.0     0.028     5e+02      36      59 ..      77     100 ..      63     102 .. 0.80
   3 ?    2.2   0.0     0.021   3.7e+02       3      15 ..     274     286 ..     274     316 .. 0.88
   4 ?   -2.8   0.0      0.76   1.4e+04      26      52 ..     526     552 ..     524     554 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.0015
   RNase_J_C 41 wnelkrkirealkkflykktkrrPmIlPviveV 73
                 ++ k+++ e+ + ++ +k ++rP+Il +++ V
  EFC39887.1 15 KASQKEEVEEEEQLLVAEKKEKRPLILGILLSV 47
                345688899999999************999876 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.028
   RNase_J_C  36 ekesdwnelkrkirealkkflykk 59 
                 ++    n+l ++ire++++fl+++
  EFC39887.1  77 QAMEAVNVLISNIREKVSNFLNSQ 100
                 455678899999********9987 PP

  == domain 3  score: 2.2 bits;  conditional E-value: 0.021
   RNase_J_C   3 eivsRGfvyvkes 15 
                 e+++RGfv v e 
  EFC39887.1 274 EVLTRGFVIVSEF 286
                 799*****99986 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 0.76
   RNase_J_C  26 vretieealeekesdwnelkrkireal 52 
                 v   i++ +e+  sd ++l++ i + l
  EFC39887.1 526 VNVRINNMNEKYFSDPDVLSQTISKVL 552
                 566688888888999999999998776 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (693 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       957  (0.0533772); expected 358.6 (0.02)
Passed bias filter:                      473  (0.0263818); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.66u 0.27s 00:00:00.93 Elapsed: 00:00:00.44
# Mc/sec: 4703.70
//
Query:       EFC39888.1  [L=207]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
      4e-05   23.5   0.0    0.00015   21.7   0.0    1.9  2  RWP-RK    RWP-RK domain
  ------ inclusion threshold ------
      0.027   14.1   5.3      0.037   13.6   5.3    1.2  1  SR-25     Nuclear RNA-splicing-associated protein


Domain annotation for each model (and alignments):
>> RWP-RK  RWP-RK domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0      0.49   4.4e+03      38      43 ..      40      45 ..      32      47 .. 0.82
   2 !   21.7   0.0   1.6e-08   0.00015       4      43 ..     109     152 ..     107     153 .. 0.89

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 0.49
      RWP-RK 38 IsRWPy 43
                I+ WP+
  EFC39888.1 40 ITMWPH 45
                788**8 PP

  == domain 2  score: 21.7 bits;  conditional E-value: 1.6e-08
      RWP-RK   4 leelqqyFslplkeAAksLgvskttLKricR....elgIsRWPy 43 
                 + +l ++ +lp + A++ Lg+s +tLKr+       lgI++WP+
  EFC39888.1 109 KYDLLRVLHLPQTLASQVLGCSFSTLKRRFYeskeDLGIEKWPQ 152
                 56888999********************98777779*******6 PP

>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   5.3   4.1e-06     0.037      39     104 ..      25      85 ..       7     122 .. 0.51

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 4.1e-06
       SR-25  39 rkassasekeeerskekkkkkrrrssssssssssssssssssssssssddrkkrgkkkdkkkkkkk 104
                 rk+s ++++  + s++   + +++s+s  sss + sssss s + +s   +++  ++k kk++k  
  EFC39888.1  25 RKKSPTNKT--HVSSSSITMWPHESNSVLSSSDICSSSSSPSNTTTS---NNNMDHHKIKKSRKTI 85 
                 222222221..222222222233222222222222222222222222...3333344444444333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (207 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1132  (0.0631379); expected 358.6 (0.02)
Passed bias filter:                      493  (0.0274974); expected 358.6 (0.02)
Passed Vit filter:                        47  (0.00262145); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.50u 0.31s 00:00:00.81 Elapsed: 00:00:00.46
# Mc/sec: 1348.00
//
Query:       EFC39889.1  [L=601]
Description: peroxisomal acyl-CoA oxidase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
      5e-27   94.6   0.0      1e-26   93.6   0.0    1.5  1  ACOX           Acyl-CoA oxidase
    1.1e-16   60.8   0.0    1.7e-16   60.2   0.0    1.3  1  Acyl-CoA_dh_M  Acyl-CoA dehydrogenase, middle domain
     0.0013   18.9   0.1     0.0053   17.0   0.1    1.9  1  Acyl-CoA_dh_1  Acyl-CoA dehydrogenase, C-terminal domain
     0.0051   17.4   0.0      0.011   16.3   0.0    1.5  1  Acyl-CoA_ox_N  Acyl-coenzyme A oxidase N-terminal


Domain annotation for each model (and alignments):
>> ACOX  Acyl-CoA oxidase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   93.6   0.0   2.3e-30     1e-26       5     146 ..     456     595 ..     452     595 .. 0.94

  Alignments for each domain:
  == domain 1  score: 93.6 bits;  conditional E-value: 2.3e-30
                 HHHHHHHHHHHHHHHHHHHHHHHHCTTSCHHHHHHHTHHHHHHHHHHHHHHHHHHHHHHHHTC.SSTTCHHHHHHHHHHHHHHHHHHTHHHHHHTTSS- CS
        ACOX   5 llealevraarllkeaakkleeekksgkskeeawneqsvelvsaakahaelvvlksfvekles.lseelkevLkkLckLyalstiekhlgdflesgyls 102
                  l+a+e+r+a+ll+e+a +++ +k +++  ++a+ e   +l+++ +a++e v+l+ +++ +e+ +++elk++Lk + +Lyal++i+k+ gdf+    ++
  EFC39889.1 456 HLQAFEYRTAKLLQECALEINVNK-KKQGIFRAFGESLPKLIRLGRAYVEQVALHDYLHGIEQvQDPELKPILKMMGDLYALDIISKNVGDFID--LIK 551
                 589*****************7665.66777*******************************996778*************************98..59* PP

                 HHHHHHHHHHHHHHHHHHHGCHHHHHHTT---HHHH--CCC-TT CS
        ACOX 103 pdqldllreailellkelrpnavaLvDafdfsDfiLnSaLGryD 146
                 +++l+ +++ ++ l++elr +av+LvD+f+f+Df L++++ ++D
  EFC39889.1 552 KNKLSAIHDMVEWLCEELRVHAVSLVDSFGFPDFLLDAPIAKRD 595
                 ****************************************9988 PP

>> Acyl-CoA_dh_M  Acyl-CoA dehydrogenase, middle domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   60.2   0.0   3.8e-20   1.7e-16       1      97 []     103     213 ..     103     213 .. 0.91

  Alignments for each domain:
  == domain 1  score: 60.2 bits;  conditional E-value: 3.8e-20
                    EEE---SS-SS-GGG---EE.EEETT.EEEEE....E.EEEEEETTTT.-SEEEEEEE.TS-------EEEEEEE...GG......GEEE-----B CS
  Acyl-CoA_dh_M   1 afalTEpqaGsdvasvktta.aerdggeyvln....G.eKiwitnaai.atlalvlar.tekpdrarglslflvp.rdap......gvsvrrieek 81 
                    afa+TE ++Gs+v+++ktta ++++++e+vln    G  K+w +naa  at+a+v+ar   k + + g+  fl p rd +      gv  ++  +k
     EFC39889.1 103 AFAMTEIEHGSNVRELKTTAiFDEQTNEFVLNtpnkGaIKWWLGNAAChATMATVFARlILKGK-DYGVHAFLCPiRDPKsmellpGVIAGDCGDK 197
                    79**********************************769*******988*********744445.79********64444899**9********** PP

                    SS-TTS-EEEEEEE.. CS
  Acyl-CoA_dh_M  82 lGlrglptgelvfedv 97 
                    +Gl+g+++g l+fe+v
     EFC39889.1 198 IGLHGVDNGFLEFENV 213
                    **************97 PP

>> Acyl-CoA_dh_1  Acyl-CoA dehydrogenase, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.0   0.1   1.2e-06    0.0053       5     145 ..     246     403 ..     243     408 .. 0.80

  Alignments for each domain:
  == domain 1  score: 17.0 bits;  conditional E-value: 1.2e-06
                    HHHTTTT--S-----..-SHHHHHHHHHHHHHHHTSB-C.......C-BGGGSHHHHHHHHHHHHHHHHHHHHHHHHHH--------......... CS
  Acyl-CoA_dh_1   5 rvametlnheRlavaaaalglarraleealeyarrrkaf.......gkplidhqlvreklaemaaeleaarllvyraaealdagkpd......... 84 
                    ++++  l  +R++++ ++l + r     a +ya +r++f        +p++d+ + + +l  + a   +   + +++++++ + + +         
     EFC39889.1 246 AAVLGELITGRVTIVSGSLNCRRVGCMIATRYASQRTQFsagkefpEQPILDYKSHKTRLMPIIASSYVFEFIKRNVVKKYCRLHLEkvsddelqe 341
                    5677788889999*99999999999999********998443333334677777777777777777777766666666644333333555667778 PP

                    .HHHHHHHHHHHHHHHHHHHHHHHHHHGGGTTSGGGHHHHHHHHTHHHHHSSS-HHHHHHHH CS
  Acyl-CoA_dh_1  85 .raeasmaKlfaselaqevadlamqllGgaGyleeypverlyrdarvlrigeGtseiqrnii 145
                      a ++ +K+  s   q+  +   +++Gg+Gy++ +++  l +d  vl  +eG + ++++++
     EFC39889.1 342 iHALSAGVKAAMSWDTQTHLQTLREMCGGHGYSAYNRLGTLRNDHDVLKTFEGDNTVLIQQL 403
                    8888888************************************************9998876 PP

>> Acyl-CoA_ox_N  Acyl-coenzyme A oxidase N-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.3   0.0   2.4e-06     0.011      44     123 ..      20      99 ..       6     101 .. 0.71

  Alignments for each domain:
  == domain 1  score: 16.3 bits;  conditional E-value: 2.4e-06
                    HHHHHHHHHHHHHHHHHHHHTTSBTTCHHHHHHHH..HHHHTHSS--TTH..HHHHTHHHHHHHHS-HHHHHHHHHHHHTTS CS
  Acyl-CoA_ox_N  44 eeryeealrkatrllkklrelqierkeseeeallagplgtglldeslplg..lhfsMFlptlkgqgteeQqakWlpraenle 123
                    ee  e al++++ l +       + k+++e  l ++ + +g++d s+ ++  +++ +F   ++++gt++ +  +l+rae++e
     EFC39889.1  20 EEAREVALKQVIFLCQSGYFNVTDMKKNPE--LFLQRMEAGIIDASMNVKlgVQLLLFAGSIMNLGTKKHHDLYLKRAERCE 99 
                    555555555555555444443333333333..3444678999999998887799999***********************98 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (601 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       449  (0.0250432); expected 358.6 (0.02)
Passed bias filter:                      427  (0.0238162); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.60u 0.28s 00:00:00.88 Elapsed: 00:00:00.44
# Mc/sec: 4057.77
//
Query:       EFC39890.1  [L=231]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0028   18.2   0.7     0.0051   17.3   0.3    1.6  1  DUF4773   Domain of unknown function (DUF4773)


Domain annotation for each model (and alignments):
>> DUF4773  Domain of unknown function (DUF4773)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.3   2.8e-07    0.0051      22     100 ..     133     210 ..     114     218 .. 0.77

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 2.8e-07
     DUF4773  22 lkkkvCvnvkynpedlslkvkvslnekvllkktis.aknpppiCvplleklakvCvrlsdikakeenlkaCleleaklle 100
                 l +k+ + +++n ++ + ++ ++ n+++++++t++ +   ppiC ++    + +C+r+++++++++    C++l++++  
  EFC39890.1 133 LYGKAETILSINLNQHTANIIMKANNEMIYQHTFTlGDLIPPICADIF-YKVGLCLRINNVHFHSQ-SPQCFKLNLQVYL 210
                 555556667778888899999*************9667789******7.5699********98755.5679999988764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (231 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       897  (0.0500307); expected 358.6 (0.02)
Passed bias filter:                      443  (0.0247086); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.45u 0.29s 00:00:00.74 Elapsed: 00:00:00.44
# Mc/sec: 1574.05
//
Query:       EFC39891.1  [L=327]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
      2e-09   37.2   0.0    4.3e-09   36.1   0.0    1.5  1  Pkinase      Protein kinase domain
  ------ inclusion threshold ------
      0.055   12.7   0.0      0.086   12.1   0.0    1.3  1  Pkinase_Tyr  Protein tyrosine kinase


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.1   0.0   4.8e-13   4.3e-09     133     260 ..     156     280 ..     150     282 .. 0.83

  Alignments for each domain:
  == domain 1  score: 36.1 bits;  conditional E-value: 4.8e-13
                 TTTEEEE-SGTTSEESSSSCS..........BCTTTSCGGGS-HHHHTTSCB..SHHHHHHHHHHHHHHHHHSS-STTTSSHHHHHHHHHHTHHHHHHH CS
     Pkinase 133 ekgelKitDFGlakelesssk..........ltsfvgtseYlAPEvlkeney..skkvDvWslGvilyelltgkppfsgekgkekvekeldqlekilki 219
                 +++  K +DF l+k + + ++          l+s  gt  Y +PE  k++++   +k+D++slG +++e+l g+ + ++   ++              i
  EFC39891.1 156 NENRAKFIDFELSKSFLTVTDdlaydvhdelLQSTSGTYFYNPPEKGKGQDHciHPKSDIYSLGKVFMEILLGRLLEKHALLSK--------------I 240
                 455699********9999888899***********************6666556********************9988222222..............2 PP

                 CTSHH...HHHTTS-HHHHHHHHHHT-SSGCCSTTHHHHHT CS
     Pkinase 220 lgetkeklpeaseiseeakdllkkllkkdpkkRltaeellq 260
                  +  ++k +  + +  ++ +l+k+++k ++k+R++ae++lq
  EFC39891.1 241 TN-PRVKEEYFDIVHIKLHELIKEMIKIERKSRPSAEQCLQ 280
                 22.2555667777889***********************97 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   9.6e-06     0.086     141     257 ..     159     280 ..     153     282 .. 0.68

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 9.6e-06
                  EEEE-STTTHEET...TTSSEE....EETTSSTSGGGGS-HHHHHHSE..EEHHHHHHHHHHHHHHHHTTSSGTTTTSHHHHHHHHH.HTTEES-BBT CS
  Pkinase_Tyr 141 vvkisDfGLardi...ekddey....vkkeeaklpvkWmapEslkekk..ftsksDvWsfGvllwEiftlgespypglkneevlekl.kegkrlekpe 228
                   +k  Df L+++    ++d  y    +  +++   + + +pE  k +   +  ksD++s G + +Ei+  g+     l+++ +l+k+ + + + e  +
   EFC39891.1 159 RAKFIDFELSKSFltvTDDLAYdvhdELLQSTSGTYFYNPPEKGKGQDhcIHPKSDIYSLGKVFMEILL-GRL----LEKHALLSKItNPRVKEEYFD 251
                  55666666666553222333333221223455566778899987655544999**************98.554....455666666634444555667 PP

                  TSBHHHHHHHHHHT-SSGGGS--HHHHHH CS
  Pkinase_Tyr 229 kcpeelyelmkkcweedpeeRptfselve 257
                   ++ +l+el+k+  + + ++Rp+ +++++
   EFC39891.1 252 IVHIKLHELIKEMIKIERKSRPSAEQCLQ 280
                  78899******************999987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (327 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       928  (0.0517597); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.23s 00:00:00.70 Elapsed: 00:00:00.39
# Mc/sec: 2498.06
//
Query:       EFC39892.1  [L=281]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (281 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1171  (0.0653132); expected 358.6 (0.02)
Passed bias filter:                      355  (0.0198003); expected 358.6 (0.02)
Passed Vit filter:                        26  (0.00145016); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.50u 0.30s 00:00:00.80 Elapsed: 00:00:00.47
# Mc/sec: 1787.33
//
Query:       EFC39893.1  [L=524]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.9e-72  243.3   0.0    2.6e-72  242.8   0.0    1.2  1  Copine         Copine
    4.6e-21   75.0   2.9    1.8e-09   37.8   1.5    3.3  2  C2             C2 domain
    0.00052   20.2   0.0     0.0014   18.8   0.0    1.7  1  vWA-TerF-like  vWA found in TerF C terminus
  ------ inclusion threshold ------
       0.14   12.1   0.0       0.25   11.3   0.0    1.3  1  VWA_3          von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> Copine  Copine
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  242.8   0.0   5.8e-76   2.6e-72       1     217 [.     306     520 ..     306     521 .. 0.96

  Alignments for each domain:
  == domain 1  score: 242.8 bits;  conditional E-value: 5.8e-76
      Copine   1 sLHyispeqpneYekallsvgeilqaydsdklipafGFGaklpsdaevsdefvlnfneenkevegiegvleaYrealpnlqlygPTnfapviekvakia 99 
                 sLH+ +  + neYe a+ s+ +il+ yd+dkl+p+fGFGaklp+  ++s++f+ln+n++n+++ g++g+l++Yr al+++qlygPTnf+p i++++  a
  EFC39893.1 306 SLHFGG--KFNEYEMAIKSITDILSYYDNDKLFPSFGFGAKLPT-GDISHCFALNGNPSNPNCVGVDGILQSYRLALNTVQLYGPTNFSPTIQTAIAYA 401
                 566655..89*******************************987.58**************************************************** PP

      Copine 100 ea....sakeasqYfvLliitDGvvtdmketidaivaAsklplSiiivGvGdadfekmrelddddalkssdgriakRdivqfVdfrdlksnasakeaal 194
                 ++    +++++++Y +Lli+tDG +td+ +ti+ +v+Ask+plS++ivGvG adf++m+ ld+dd++ s+  +i  RdivqfV+fr+++    ++ + l
  EFC39893.1 402 SQlsveQSQNNQKYLILLILTDGEITDLPDTIKELVKASKYPLSVVIVGVGSADFSQMHLLDGDDKRLSNGNEISIRDIVQFVPFRKFNY---QNYHLL 497
                 99877678999*******************************************************************************...88999* PP

      Copine 195 akavLaeiPkqlkaylelrklkp 217
                 a++ L+eiP+q+++y+++ k+kp
  EFC39893.1 498 ARETLMEIPSQVVQYFKSMKIKP 520
                 ******************99987 PP

>> C2  C2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   37.8   1.5   3.9e-13   1.8e-09       8      98 ..      20     138 ..      16     143 .. 0.88
   2 !   31.1   0.0   4.9e-11   2.2e-07       8      87 ..     175     263 ..     170     276 .. 0.79

  Alignments for each domain:
  == domain 1  score: 37.8 bits;  conditional E-value: 3.9e-13
                 EEEESSSSSSTTSSCEEEEEEEE........................ECEEEEEE-SCSSSSSSEEEEEEEEEESCHTTSEEEEEEEEECS....SSTE CS
          C2   8 ieAknLpnkdkkgssdpyvkvsl........................dgkqkakTrviknslnPvWnekftfevaeleeakLeveVfdndr....lskd 78 
                 i++ nL+nkd+ ++sdp + v+l                        +  ++++T++ kn+lnP + ++f ++ +++e + +++ ++d d+    l++d
  EFC39893.1  20 ISCSNLKNKDILSKSDPLALVKLgekqsinsttnsttttsstsnniyNYIEIGRTEIQKNNLNPSFIKTFIVNYKFEEIQPIQFFIYDVDNesstLNDD 118
                 789********************99999988888888888888888888888888878******************************88878877999 PP

                 EEEEEEEEEGHHHHTTHHHH CS
          C2  79 dfiGkveiplstllsgeeae 98 
                 df+Gk+e+++s++ s+ + +
  EFC39893.1 119 DFLGKCELKISDIVSKPNST 138
                 9***********88876655 PP

  == domain 2  score: 31.1 bits;  conditional E-value: 4.9e-11
                 EEEESSSSSSTTSSCEEEEEEEE....ECEEEEEE-SCSSSSSSEEEEEEEEEESC....HTTSEEEEEEEEECSSSTEE..EEEEEEEE CS
          C2   8 ieAknLpnkdkkgssdpyvkvsl....dgkqkakTrviknslnPvWnekftfevae....leeakLeveVfdndrlskdd..fiGkveip 87 
                 ie+knL++kd +g+sdp+  +s     +    +k+++i n+lnP++n  ft+++ +    +e+ +L ++++d+d+ s+ d  + Gk++++
  EFC39893.1 175 IEGKNLAKKDLFGKSDPFFIISRnvngKLIDLYKSEIIMNNLNPIFN-PFTISMFKlcnlDENLQLILTIYDWDKHSDPDlkVTGKIQVK 263
                 799***************99999998778889**************8.4444444444599**************877775556655544 PP

>> vWA-TerF-like  vWA found in TerF C terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   3.1e-07    0.0014      98     159 ..     407     469 ..     369     489 .. 0.74

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 3.1e-07
  vWA-TerF-like  98 rkepaelptl.vlFitDGgvkkkkeiekalreaskepiFwqFvglgkseygvLeklDdlegRv 159
                    +++++++  l +l +tDG++++  ++ k+l +ask p+    vg+g++++  ++ lD  ++R 
     EFC39893.1 407 EQSQNNQKYLiLLILTDGEITDLPDTIKELVKASKYPLSVVIVGVGSADFSQMHLLDGDDKRL 469
                    222233334404567***************************************999866664 PP

>> VWA_3  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   5.6e-05      0.25      61     135 ..     372     453 ..     355     462 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5.6e-05
       VWA_3  61 lqealqkikelelslgasnlegaLkealr...qp.....akpgevrsvilltDgssaqgeervsdlisrarekirfhalglgs 135
                 lq  + ++++ +l +g +n   ++++a++   q      + ++    +++ltDg ++   + + +l+++++  ++++ +g gs
  EFC39893.1 372 LQSYRLALNTVQL-YGPTNFSPTIQTAIAyasQLsveqsQNNQKYLILLILTDGEITDLPDTIKELVKASKYPLSVVIVGVGS 453
                 78888999*****.***********999543322555558999999999******9887778888998887888888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (524 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       692  (0.0385967); expected 358.6 (0.02)
Passed bias filter:                      414  (0.0230911); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.56u 0.27s 00:00:00.83 Elapsed: 00:00:00.46
# Mc/sec: 3419.23
//
Query:       EFC39894.1  [L=462]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    6.9e-52  176.4   0.0    8.9e-52  176.0   0.0    1.1  1  CN_hydrolase  Carbon-nitrogen hydrolase
  ------ inclusion threshold ------
      0.014   15.6   0.0      0.027   14.7   0.0    1.4  1  DUF2267       Uncharacterized conserved protein (DUF2267)
       0.51   10.3   2.3        1.1    9.3   2.3    1.5  1  DUF3377       Domain of unknown function (DUF3377)


Domain annotation for each model (and alignments):
>> CN_hydrolase  Carbon-nitrogen hydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  176.0   0.0   1.5e-55   8.9e-52      19     260 ..     157     410 ..     133     411 .. 0.95

  Alignments for each domain:
  == domain 1  score: 176.0 bits;  conditional E-value: 1.5e-55
                   HHHHHHHHHHHHTTESEEEEETTTTTBS....SSHHHHHHHHB.HSSSHHHHHHHHHHHHHTEEEEEEEEEEEC.CTTEEEEEEEEEEEETTSEEEE CS
  CN_hydrolase  19 qklleliaeAarkgadLivlPElfitgy....keeahfleaAe.aglgetlallaalarkngiavviglierel.tngklqayntavlldldgklvg 109
                   +k++++i++A   g+++i+l+E++ +++    +e++ ++e++e a+ g ++++l++la+k+++++v  ++er+  +n+++  +ntav++ + g+++g
    EFC39894.1 157 SKIEKIIDSAYLMGVNVIGLQEAWTMPFafctREKQPWMEFSEeAETGRSTQFLSKLAKKYNMVIVSSILERDSeHNDVI--WNTAVVIGNRGNYIG 251
                   6899999999999*******************888888888888889*************************88******..*************** PP

                   EEE-SS--EECTTSCECCGHHTSCS-SS.S-EEEETTEEEEEEEGGGGGSHHHHHHHHHTT-SEEEEBH.GCCCTCHHHHHHHHHHHHHHHHHHTSE CS
  CN_hydrolase 110 kyrKlhLfpgeprpptaverelfepgdg.ipvfdtpvgkiGaaiCyeigfpellralalkgaeilvnlserapvpksmgppqwellgraralengcf 205
                   k rK+h    +pr ++++e +++ +g+  +pvf+t++g+iG++iCy ++ p+++  ++l+gaei++n    + + + +++p w++ +r+ a++n +f
    EFC39894.1 252 KVRKNH----IPRVGDFNEATYYLEGNLgHPVFETDFGRIGINICYGRHIPLNWQSYGLNGAEIVFNP---SATVGTLSEPMWSIEARNAAIANSYF 341
                   ******....69*******************************************************2...356789******************** PP

                   EEEEEBEEE..............HCETTEEEE--EEEE-TTS-EEEECCSSSTEEEEEEEEHHHHHHHH CS
  CN_hydrolase 206 viaanqvgg..............yeqlilwpvghSaiidpdGrilaglgeeeegvliaeidladvratr 260
                   v+ +n+vg+              ++++ ++++g+S++ +pd +   +l++  +g+l++eidl++ r+++
    EFC39894.1 342 VASINRVGTevfpneftsadgkkAHKDFGHFYGSSYVSAPDASRSPELTRLGDGLLVTEIDLNLNRQVK 410
                   **************************************************************9988876 PP

>> DUF2267  Uncharacterized conserved protein (DUF2267)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   0.0   4.6e-06     0.027      68     115 ..      39      86 ..      28      93 .. 0.93

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 4.6e-06
                 -SHHHHHHHHHHTS.....EHHHHHHHHHHHHHHHS-HHHHHHHHHTS CS
     DUF2267  68 fdreeflervaeelgvdpedaeqaaraVfaalkealsegeiedvaaqL 115
                 +++ee l r ++  +++p d+ +  ++V +alk++l+++++ +v++ L
  EFC39894.1  39 VKSEEVLIRMENNQHIKPNDPMTSLSTVYDALKQHLPQETFSQVRRIL 86 
                 678999**************************************9977 PP

>> DUF3377  Domain of unknown function (DUF3377)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.3   2.3   0.00018       1.1      24      46 ..       8      30 ..       1      39 [. 0.83

  Alignments for each domain:
  == domain 1  score: 9.3 bits;  conditional E-value: 0.00018
     DUF3377 24 sgtvnaiaVvvPlvLllciLvli 46
                ++t++  +Vvv  +LllciL ++
  EFC39894.1  8 KSTTTTTMVVVFNMLLLCILTIT 30
                5677999*************876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (462 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       723  (0.0403257); expected 358.6 (0.02)
Passed bias filter:                      404  (0.0225333); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.61u 0.27s 00:00:00.88 Elapsed: 00:00:00.48
# Mc/sec: 2922.82
//
Query:       EFC39895.1  [L=179]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.017   13.9   0.0      0.092   11.5   0.0    1.9  2  DCD       2'-deoxycytidine 5'-triphosphate deaminase (DCD)
      0.032   13.9   0.0      0.062   13.0   0.0    1.5  1  dUTPase   dUTPase


Domain annotation for each model (and alignments):
>> DCD  2'-deoxycytidine 5'-triphosphate deaminase (DCD)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0     1e-05     0.092      38     140 ..      26     123 ..       1     149 [. 0.66
   2 ?    1.8   0.0    0.0091        81     307     353 ..     120     166 ..     108     168 .. 0.81

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 1e-05
         DCD  38 rLgkkayrvr.asFlpgkgekvaekleelklheldLt.egavlekgcvYivplleslaLpadlsaaanpksstGRlDvftRvitdkgeefdeveagYkG 134
                  Lg+++y v+  s l+  ++++ +  ++ +++ +d+  eg +l+ g +Y+   +e  + +++     + ksstGRl + +   + kg+       g++G
  EFC39895.1  26 NLGSNSYDVHlGSKLAIYKDEILDAKKNNEIELFDIPdEGYILQPGELYLGVTEEY-TETHEHVPFLEGKSSTGRLGISIHATAGKGD------VGFQG 117
                 3666666665346677777788877788888888887699*********9655555.55555567899********998776665553......46666 PP

         DCD 135 plylei 140
                    lei
  EFC39895.1 118 TWTLEI 123
                 666665 PP

  == domain 2  score: 1.8 bits;  conditional E-value: 0.0091
         DCD 307 vLevRsrevPFiledgqivgrlvyermaekp.ealYGeelgsnYqgqg 353
                  Le+ + + P  + +g  +g+l+y  +++ +    Y ++ +++Y++q+
  EFC39895.1 120 TLEINCVK-PTRVYKGMPIGQLIYFPVNKDTiLVPYCKKSNAKYNAQS 166
                 57777765.889999**********9998651567*********9996 PP

>> dUTPase  dUTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.0   0.0   6.9e-06     0.062      24     120 ..      66     163 ..      51     171 .. 0.81

  Alignments for each domain:
  == domain 1  score: 13.0 bits;  conditional E-value: 6.9e-06
                 EEEETTEEEEEEEEEEEE--TTEEEEEEE-HHHHHHHEEEEE..EEEETTBTSEEEEEEEE-SSS-EEE-TT-EEEEEEEEEBEC..GEEEEESSTTTE CS
     dUTPase  24 ltvkpgetvlvptdisiklpdglaalilpRSglaakglivvp..gvidsdyrGevkvvlfnltkkdvkikkgdRiAqLifarilt..aeleevetlkat 118
                 ++++pge +l +t+ + +  +++ +++ ++S+  ++g+ ++   g  d  ++G    +l  +  k+ ++ kg  i qLi+ ++++  + +   ++ +a+
  EFC39895.1  66 YILQPGELYLGVTEEYTE-THEHVPFLEGKSSTGRLGISIHAtaGKGDVGFQG--TWTLEINCVKPTRVYKGMPIGQLIYFPVNKdtILVPYCKKSNAK 161
                 678888888888888888.8899*****************9988888999***..888888888899****************9974444444444555 PP

                 SS CS
     dUTPase 119 er 120
                 ++
  EFC39895.1 162 YN 163
                 54 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (179 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       285  (0.015896); expected 358.6 (0.02)
Passed bias filter:                      247  (0.0137766); expected 358.6 (0.02)
Passed Vit filter:                        17  (0.000948185); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.47u 0.26s 00:00:00.73 Elapsed: 00:00:00.44
# Mc/sec: 1210.52
//
Query:       EFC39896.1  [L=148]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.36   10.2  11.3       0.53    9.7  11.3    1.3  1  SelP_N    Selenoprotein P, N terminal region


Domain annotation for each model (and alignments):
>> SelP_N  Selenoprotein P, N terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7  11.3   2.9e-05      0.53     157     213 ..      19      71 ..       5      94 .. 0.40

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 2.9e-05
      SelP_N 157 sseaeeeckevtkaaeekpaeaeektehehahshkqghkhhekhghhHke.keelses 213
                 ss+++ +++++ ++++++++  + + eh+ +h+h     h++kh+ hH + ++e++++
  EFC39896.1  19 SSISNTTTTNTNNNNNNTTNYYDIVIEHKVHHKH-----HNSKHHYHHYDmSTEHEHT 71 
                 2222222222222233333333333333333333.....2222222222212222222 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (148 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2176  (0.121368); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.49u 0.29s 00:00:00.78 Elapsed: 00:00:00.47
# Mc/sec: 942.07
//
Query:       EFC39897.1  [L=768]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
     1e-164  549.6  19.8   1.4e-164  549.1  19.8    1.2  1  Cullin        Cullin family
      8e-25   86.7   2.6      8e-25   86.7   2.6    3.0  3  Cullin_Nedd8  Cullin protein neddylation domain
     0.0082   16.3   1.6      0.063   13.5   0.0    3.2  4  DHHA2         DHHA2 domain
  ------ inclusion threshold ------
      0.012   15.4   0.0      0.045   13.5   0.0    2.0  1  UPF0167       Uncharacterised protein family (UPF0167)


Domain annotation for each model (and alignments):
>> Cullin  Cullin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  549.1  19.8  3.2e-168  1.4e-164       1     618 []      38     667 ..      38     667 .. 0.94

  Alignments for each domain:
  == domain 1  score: 549.1 bits;  conditional E-value: 3.2e-168
      Cullin   1 Wekleeaiqeil.......kknvsklsfeelYravynlvlsk.....ekkqgekLydklkelieehlkellkellkeesdeelLkalkkeWedhktsmk 87 
                 W+ l++++++++       +k +  +++ +lY++v nl+++k     +    e Lyd+++++i+++lk+l+   lke++++ lL +  k+W+dh+  ++
  EFC39897.1  38 WKYLQQGFNKLIdfldknmSKPFDYNEYADLYSTVFNLCTQKvdtnkKGGATELLYDRYRTCISDYLKSLVVVALKEKQGDGLLMEAVKRWRDHQLVVR 136
                 777777777777655543246777899*************99998663345689******************999************************ PP

      Cullin  88 mirdifmyldrvyvk..klpsvydlglelfrdhvfriklkdrlieallkliekeRegevidrsllksviemlvelgedsedkkvYeeeFekafleatee 184
                 ++ ++++yldr+y+k  ++++++++gl+++++ v+  ++k+ + +all++i keReg+ idrs++k+ i ++ e+g  s   + Y e+Fe+ +l++t++
  EFC39897.1 137 YMVKLYNYLDRYYTKhnNRDDLRNVGLKCYQELVYG-SIKKDMAQALLDKIYKEREGDLIDRSMMKDGITLFIEMGLGS--LNAYDEDFERTLLQNTQS 232
                 *************999999****************5.799***********************************9987..69**************** PP

      Cullin 185 fYraeaeellaensvaseYlkkaeerleeEeervekyldsstkkkllevleeelikkhleelleee...lkklle.dekledLkrlykllsrvdgleeL 279
                 +Y+ ++++++ae+ ++++Y+kk+ee+le Ee+r++ yl+++tk+kl++ +++eli+kh ++ll+++   l +ll+  +k+edL+r+y+l++r++ l+++
  EFC39897.1 233 YYSIQSSKWIAED-SCPDYMKKTEEKLESEERRATAYLHTNTKPKLISKVQDELIRKHQTTLLNMDgsgLVALLKtGDKHEDLSRMYTLFDRIESLQPM 330
                 ***********97.899************************************************8899*****8645********************* PP

      Cullin 280 rkaleeyikeegkaivkdakekektedakkyveklLelkdkfdklvkeafnndkefekaldeafeefvnknkv......nsksaellakYiDelLkkgl 372
                  ++l+++i+eeg +i +++ + +++ dak y+e+lL+l+  ++klv+  f++++ f  al++af++fvn + v       s +ael++ Y+D+++k+  
  EFC39897.1 331 SEKLRDFITEEGVKIHTNQCQ-QENIDAKGYIEELLKLHLTYSKLVNIQFKQNPLFLDALRDAFTHFVNLEVVspgdknRSTTAELISTYCDSIMKEV- 427
                 ************999999765.8889*******************************************7766999988788**************96. PP

      Cullin 373 kglseeeleekldkvlvlfryiedKDvFekyYkkhLakRLllgksasddaEksmiskLkeecGseftskLegMfkDiklskdlnkefkeyleeekkkkk 471
                  ++ ee+l+e l+++++lf y++dKD+F ++Y++hL+kRLl     + daE+++i kLk+ +G++ft+kLegM+kD ++s++l ++fk+y++ +k+ + 
  EFC39897.1 428 DKVGEENLDELLENIVKLFGYLKDKDMFLAFYREHLSKRLLVASRLNLDAERNFIGKLKMRMGMSFTQKLEGMIKDKSISENLRNDFKNYTT-NKSITL 525
                 556799************************************************************************************98.566669 PP

      Cullin 472 kvdlsvkVLtagaWpterskesevsvklpeeledlieeFeefYkskhsgrkLtWlhslgsaelkatfpkkkyelqvstfqmvvLllFndeeeklsyeei 570
                  +d++ +VLt g+Wp+ ++ +   ++++p+el+ ++++F++fY s  ++rkL W+hslg+a ++ +f+++++e++++t+q+++LllFn++  ++++++i
  EFC39897.1 526 PFDFNPEVLTLGCWPQ-MKID---KMTIPQELSVCLDTFKKFYDSITQQRKLDWIHSLGTAIVTGRFSAGTKEISTNTYQACILLLFNNQ-AEMTFQDI 619
                 9**************3.4445...8*********************************************99****************55.8******* PP

      Cullin 571 qeatglpekeLkrtLqsLavakkarvLlkepkskdveptdefsvNaeF 618
                 q++ +lp +e+kr+L sL+  k a++L ++ ++k v+ptd+f+vNa+F
  EFC39897.1 620 QNSLNLPPTEIKRNLLSLCATKAANLLSTDGNKKAVNPTDKFTVNADF 667
                 ******************8888999999999779************99 PP

>> Cullin_Nedd8  Cullin protein neddylation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.2   0.0         4   1.8e+04      41      53 ..     275     287 ..     271     289 .. 0.57
   2 ?   -1.3   0.0      0.52   2.3e+03      28      51 ..     614     637 ..     600     640 .. 0.81
   3 !   86.7   2.6   1.8e-28     8e-25       1      63 []     698     760 ..     698     760 .. 0.98

  Alignments for each domain:
  == domain 1  score: -4.2 bits;  conditional E-value: 4
  Cullin_Nedd8  41 iadikkrIesLie 53 
                   +++i k+ ++Li+
    EFC39897.1 275 PKLISKVQDELIR 287
                   5555555556655 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 0.52
  Cullin_Nedd8  28 evieqlskrftpsiadikkrIesL 51 
                    + ++++++ ++ +++ik+++ sL
    EFC39897.1 614 MTFQDIQNSLNLPPTEIKRNLLSL 637
                   466788999999999999998887 PP

  == domain 3  score: 86.7 bits;  conditional E-value: 1.8e-28
  Cullin_Nedd8   1 dRklaiqaaIVRiMKsrktlshneLvsevieqlskrftpsiadikkrIesLiekeYleRdend 63 
                   +Rk++i+aa+VRiMK+rk l+++eL++e+i+qls++f+p++++ik+r+e+Li +eYleRd++d
    EFC39897.1 698 ERKYVIDAALVRIMKTRKILKYQELMTETIKQLSSHFQPDPKLIKRRVEDLIAREYLERDAKD 760
                   79**********************************************************976 PP

>> DHHA2  DHHA2 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.4   6.3e+03      60      91 ..     196     230 ..     166     274 .. 0.52
   2 !   13.5   0.0   1.4e-05     0.063      10     138 ..     501     657 ..     494     658 .. 0.74
   3 ?   -1.6   0.1      0.62   2.8e+03      34      75 ..     674     724 ..     666     751 .. 0.58
   4 ?   -1.3   0.0      0.49   2.2e+03       7      27 ..     742     762 ..     739     766 .. 0.84

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.4
                 HHHH.HHT-SEEEEEEE........ETTTEEEEEE CS
       DHHA2  60 ekfaeerkldllvlmttfe...eegdirrelllaa 91 
                 ++ + ++++ l++ m   +    ++d++r+ll  +
  EFC39897.1 196 DRSMMKDGITLFIEMGLGSlnaYDEDFERTLLQNT 230
                 44443555666666666555556666666665444 PP

  == domain 2  score: 13.5 bits;  conditional E-value: 1.4e-05
                 STTS-HHHHTTTTEEEEE...ETTEEEEEEEEEES-HHHHHT.THHH............HHHHHHHHH.HHT-SEEEEEEE.................E CS
       DHHA2  10 lsglsledllrrDyKeft..geggvkvgiasvpvslsewleekrkge............llaalekfaeerkldllvlmttfe............eegd 82 
                 ++++s+++ lr+D+K +t  ++ ++ + +   +++l +w + k ++             +++  +++ ++rkld +  + t              +++ 
  EFC39897.1 501 IKDKSISENLRNDFKNYTtnKSITLPFDFNPEVLTLGCWPQMKIDKMtipqelsvcldtFKKFYDSITQQRKLDWIHSLGTAIvtgrfsagtkeiSTNT 599
                 7899**************997778888888888889999988886668899999967767777777779999*99999999666677888655544444 PP

                 TTTEEEEEE...STTHHHHHT---BTEEET....................T---HHHHTHH CS
       DHHA2  83 irrelllaaldaaeklaealekaseeleLeewkeg.....aewrrvykqgnvkasRKqvaP 138
                 ++  +ll++   +++++  +++ +++l+L++ + +      + +++ +   ++ ++K v P
  EFC39897.1 600 YQACILLLF---NNQAEMTFQDIQNSLNLPPTEIKrnllsLCATKAANLLSTDGNKKAVNP 657
                 444556655...6667777877777899999888877777666666666666666666655 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 0.62
                 EEEEEEEES-HHHHHT.THHH........HHHHHHHHH.HHT.-SEEEEEE CS
       DHHA2  34 vgiasvpvslsewleekrkge........llaalekfaeerk.ldllvlmt 75 
                 + i  v+v++ ++ +++ +++        + aal ++++ rk l+   lmt
  EFC39897.1 674 IKIPNVVVHVTQQQKQDISQKaqeerkyvIDAALVRIMKTRKiLKYQELMT 724
                 555555555554444433333333355556666666666666555555555 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.49
                 HT-STTS-HHHHTTTTEEEEE CS
       DHHA2   7 ksdlsglsledllrrDyKeft 27 
                 k  +++l +++ l+rD K+ +
  EFC39897.1 742 KRRVEDLIAREYLERDAKDSS 762
                 667899999*********865 PP

>> UPF0167  Uncharacterised protein family (UPF0167)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.5   0.0     1e-05     0.045      73     137 ..     205     281 ..     146     301 .. 0.65

  Alignments for each domain:
  == domain 1  score: 13.5 bits;  conditional E-value: 1e-05
     UPF0167  73 e..........eeldeelleellkrtpgyiswqqeqWla..hCddacaflgevgaeelealkiklekeelaaikddl 137
                 +          + +de+  + ll++t +y s+q+ +W+a   C d+++  +e   +e +++++ l++++  ++ +++
  EFC39897.1 205 TlfiemglgslNAYDEDFERTLLQNTQSYYSIQSSKWIAedSCPDYMKKTEEKLESEERRATAYLHTNTKPKLISKV 281
                 144446666667899**********************9844699999877776666655555555555544444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (768 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1118  (0.0623571); expected 358.6 (0.02)
Passed bias filter:                      485  (0.0270511); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.72u 0.30s 00:00:01.02 Elapsed: 00:00:00.47
# Mc/sec: 4886.72
//
Query:       EFC39898.1  [L=810]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    4.1e-48  164.0   1.7    5.3e-27   94.8   1.5    3.9  2  Pkinase         Protein kinase domain
    2.2e-23   82.9   1.1    3.7e-18   65.8   0.8    3.1  2  Pkinase_Tyr     Protein tyrosine kinase
     0.0025   17.2   0.1     0.0062   15.9   0.1    1.6  1  Kdo             Lipopolysaccharide kinase (Kdo/WaaP) family
  ------ inclusion threshold ------
      0.023   14.6   0.0      0.046   13.6   0.0    1.5  1  APH             Phosphotransferase enzyme family
        3.7    8.3   6.0       0.66   10.7   0.3    2.7  3  CtnDOT_TraJ     Homologues of TraJ from Bacteroides conjugati


Domain annotation for each model (and alignments):
>> Pkinase  Protein kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   94.8   1.5   1.5e-30   5.3e-27       1     156 [.     233     417 ..     233     425 .. 0.87
   2 !   61.5   0.0   2.2e-20   7.8e-17     153     264 .]     477     611 ..     466     611 .. 0.77

  Alignments for each domain:
  == domain 1  score: 94.8 bits;  conditional E-value: 1.5e-30
                 EEEEEEEEEESSEEEEEEEETTTTEEEEEEEEECHCHCHHHH........................HHHHHHHHHHHHHS.CTTB--EEEEEEE..... CS
     Pkinase   1 yekleklGeGsfGkVykaveketgkivAvKkikkekakkkke........................kkvlrEikilkklk.hpnivrlyevfee..... 69 
                 y++ e +G+G++G+V  ++e +t++++A+Kk  +   ++++                          ++lrE+k+l++++ +p+iv+l++v+       
  EFC39898.1 233 YKVTEIIGSGTYGVVAICKELQTDQQFALKKNIRVFPDENDLnqstnsttnngkyvafnnsgklhqLRMLRELKMLHHFRnCPYIVNLKDVYVPnqlnq 331
                 78899*************************8655443333333456677888********999988799***********9***********9866665 PP

                 SSEEEEEEE--TTEBHHHHHHHHSS--HHHHHHHHHHHHHHHHHHHHTTEE-SS-SGGGEEEETTTEEEE-SGTTSEESSSSCSBCT CS
     Pkinase  70 kdelylvleyveggeladllerkgslseeeakkiakqilegleylHskgiiHrDlKpeNiLidekgelKitDFGlakelesssklts 156
                  +++ +++ ++e + l d+    +sls++++k +++qi+ ++ y+ +++i+HrDlKpeNiL++++ ++ i+DFGla+ + +s + ++
  EFC39898.1 332 LRDIEMITSLMEAD-LRDIFDSGQSLSPKHVKWFMYQICLSVYYMQKAKILHRDLKPENILVNSQCDVAICDFGLARGYYNSLQNKK 417
                 66788*******77.******9999****************************************************9998876444 PP

  == domain 2  score: 61.5 bits;  conditional E-value: 2.2e-20
                 S.BCTTTSCGGGS-HHHH..TTSCBSHHHHHHHHHHHHHHHHHSS..-STTTSSHHHHHHHHHHTHHHHHHHCT.SHH...HHHTTS............ CS
     Pkinase 153 k.ltsfvgtseYlAPEvl..keneyskkvDvWslGvilyelltgk..ppfsgekgkekvekeldqlekilkilg.etkeklpeasei............ 233
                 k  +++v++++Y++PE+l   ++ y k+ D+Ws+G+i+yell+gk   +f+g+         +dq+++i+k lg +   +  + se             
  EFC39898.1 477 KlSSNYVVSRWYRPPELLtnATQVYNKTLDMWSVGCIMYELLSGKgeVLFKGSG-------SIDQIQRIIKQLGtP-AIDDFNGSEAardyiynkfpic 567
                 246899************8777899*****************975327788444.......566666666666642.2222222222344567778999 PP

                 .............-HHHHHHHHHHT-SSGCCSTTHHHHHTSGGG CS
     Pkinase 234 .............seeakdllkkllkkdpkkRltaeellqhpyl 264
                               + a+dl+k++l+ ++ kR+   ++l hpy+
  EFC39898.1 568 krrsftkrlppntCPMAIDLMKRMLTFNMYKRINPLDALLHPYF 611
                 99999****9999999***************************8 PP

>> Pkinase_Tyr  Protein tyrosine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   65.8   0.8     1e-21   3.7e-18      38     168 ..     291     424 ..     233     429 .. 0.79
   2 !   13.6   0.0   8.5e-06     0.031     158     201 ..     474     520 ..     466     575 .. 0.78

  Alignments for each domain:
  == domain 1  score: 65.8 bits;  conditional E-value: 1e-21
                  TTSSHHHHHHHHHHHHHHHTS.-BTTB--EEEEEE.....SSSSEEEEEE--TTEBHHHHHHHTCTTTSBHHHHHHHHHHHHHHHHHHHHTTEEEST- CS
  Pkinase_Tyr  38 eeateeekeelleeakimkkl.khpnivkllgvct.....keepllivteyvkgGdLlkfLrkkekekltlkdllsfalqvAkGmeyLeskklvHrdl 129
                  +++ + ++ ++l+e+k+++++ + p iv+l  v++     + + + ++t +++  dL++   +   ++l+ k++  f++q++  + y+++ k++Hrdl
   EFC39898.1 291 NNSGKLHQLRMLRELKMLHHFrNCPYIVNLKDVYVpnqlnQLRDIEMITSLMEA-DLRDIFDSG--QSLSPKHVKWFMYQICLSVYYMQKAKILHRDL 385
                  3445556889*************************65443334499*****985.9****9996..9******************************* PP

                  SGGGEEEEETTEEEE-STTTHEETTTSSEEEETTSSTSG CS
  Pkinase_Tyr 130 aarNvLlsenkvvkisDfGLardiekddeyvkkeeaklp 168
                     N+L++++  v i+DfGLar  +++ + +k+ ++  p
   EFC39898.1 386 KPENILVNSQCDVAICDFGLARGYYNSLQNKKQLSSSSP 424
                  ************************988888777776666 PP

  == domain 2  score: 13.6 bits;  conditional E-value: 8.5e-06
                  EEEETTSSTSGGGGS.-HHHHHHSE..EEHHHHHHHHHHHHHHHHTT CS
  Pkinase_Tyr 158 eyvkkeeaklpvkWm.apEslkekk..ftsksDvWsfGvllwEiftl 201
                  +++k +++ +  +W+ +pE l++ +  +++  D+Ws G +++E+++ 
   EFC39898.1 474 NQTKLSSNYVVSRWYrPPELLTNATqvYNKTLDMWSVGCIMYELLSG 520
                  445555566677787699*99987666*****************993 PP

>> Kdo  Lipopolysaccharide kinase (Kdo/WaaP) family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.1   1.7e-06    0.0062      53     166 ..     296     403 ..     289     420 .. 0.78

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 1.7e-06
         Kdo  53 lgrtravrEfrllkrLeeagvav.pkpvaagavkvgleyrAlllterlegaqdLedllakwaelaeelkrallkavgrliaklhragvnHadlyaknil 150
                 l+++r+ rE+++l+ +++    v +k v+   ++ +  +   ++t  +e   dL d+  ++++l+ +  +  + ++   +  + +a++ H+dl + nil
  EFC39898.1 296 LHQLRMLRELKMLHHFRNCPYIVnLKDVYVP-NQLNQLRDIEMITSLME--ADLRDIFDSGQSLSPKHVKWFMYQICLSVYYMQKAKILHRDLKPENIL 391
                 7788888888888888887666624444444.44445566677777777..59999999999999999999**************************** PP

         Kdo 151 lqqeeeeeaeiwliDl 166
                 ++ +      +++ D+
  EFC39898.1 392 VNSQC----DVAICDF 403
                 *9997....5666665 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   1.3e-05     0.046     165     196 ..     377     406 ..     292     408 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.3e-05
                 -EEEE-SS-SGGGEEEC..TTEEEEE---TT- CS
         APH 165 ptvllHgDlhpgNllvdpddgrvtGviDfeda 196
                 ++ +lH+Dl+p N+lv+  +  v ++ Df++a
  EFC39898.1 377 KAKILHRDLKPENILVN-SQCDV-AICDFGLA 406
                 56699************.54555.9*****98 PP

>> CtnDOT_TraJ  Homologues of TraJ from Bacteroides conjugative transposon
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.3   0.00018      0.66      18      45 ..      61      88 ..      59     100 .. 0.90
   2 ?   -2.5   0.8       2.4   8.8e+03      37      49 ..     122     134 ..     109     150 .. 0.50
   3 ?   -2.4   0.0       2.2     8e+03      31      50 ..     234     253 ..     232     262 .. 0.80

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.00018
  CtnDOT_TraJ 18 yivhAgGGgallqkvnslassststals 45
                 yi + gGGg+  ++ ns+++ +tst++s
   EFC39898.1 61 YITKSGGGGSNCNNTNSTVNCTTSTITS 88
                 9***********************9987 PP

  == domain 2  score: -2.5 bits;  conditional E-value: 2.4
  CtnDOT_TraJ  37 ssststalsaaka 49 
                  + +t+t+++++ +
   EFC39898.1 122 NTTTNTTTTTTIT 134
                  2233333333333 PP

  == domain 3  score: -2.4 bits;  conditional E-value: 2.2
  CtnDOT_TraJ  31 kvnslassststalsaakag 50 
                  kv++++ s+t ++++  k++
   EFC39898.1 234 KVTEIIGSGTYGVVAICKEL 253
                  899******99998877665 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (810 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      3722  (0.207597); expected 358.6 (0.02)
Passed bias filter:                      337  (0.0187964); expected 358.6 (0.02)
Passed Vit filter:                        76  (0.00423894); expected 17.9 (0.001)
Passed Fwd filter:                        28  (0.00156172); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 1.13u 0.34s 00:00:01.47 Elapsed: 00:00:00.53
# Mc/sec: 4633.55
//
Query:       EFC39899.1  [L=155]
Description: hypothetical protein NAEGRDRAFT_59158 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    0.00021   21.0  22.1     0.0003   20.5  22.1    1.2  1  SR-25        Nuclear RNA-splicing-associated protein
     0.0069   15.2  13.9     0.0082   14.9  13.9    1.0  1  MAP65_ASE1   Microtubule associated protein (MAP65/ASE1 famil
  ------ inclusion threshold ------
      0.014   16.2   5.3      0.019   15.8   5.3    1.3  1  Chorion_2    Chorion family 2
       0.23   10.9   6.1        0.3   10.6   6.1    1.1  1  Sec62        Translocation protein Sec62
       0.32    9.8  14.8       0.33    9.8  14.8    1.0  1  Apt1         Golgi-body localisation protein domain
       0.51    8.8  19.1       0.57    8.7  19.1    1.0  1  Macoilin     Macoilin family
       0.52    8.4  11.4       0.59    8.2  11.4    1.0  1  Hid1         High-temperature-induced dauer-formation protein
       0.83    8.5  10.5       0.98    8.3  10.5    1.1  1  NUC194       NUC194 domain
          1    9.3  12.4        1.4    9.0  12.4    1.1  1  CDK2AP       Cyclin-dependent kinase 2-associated protein
        1.8    7.9   6.1        2.2    7.7   6.1    1.1  1  FAM70        FAM70 protein
        2.9    7.5  21.9        3.6    7.2  21.9    1.1  1  PAP1         Transcription factor PAP1
        3.2    6.6  12.0        3.6    6.5  12.0    1.1  1  Miga         Mitoguardin
        3.3    7.9   7.7        4.3    7.5   7.7    1.2  1  Shisa        Wnt and FGF inhibitory regulator
        3.8    7.1  19.7         32    4.0  19.7    1.9  1  FAM220       FAM220 family
          4    5.7  13.7        4.7    5.5  13.7    1.2  1  Herpes_pp85  Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV U


Domain annotation for each model (and alignments):
>> SR-25  Nuclear RNA-splicing-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.5  22.1   2.5e-07    0.0003      21     134 ..      26     137 ..      18     145 .. 0.34

  Alignments for each domain:
  == domain 1  score: 20.5 bits;  conditional E-value: 2.5e-07
       SR-25  21 kksskdssrsssasksqsrkassasekeeerskekkkkkrrrssssssssssssssssssssssssddrkkrgkkkdkkkkkkkkk....kkkkkekkk 115
                 kks+k+++++s   +s+  k  s+++      k+  +   +++ss s+ssssssssss ssss ss++    +kkk++k +   k      ++  +k  
  EFC39899.1  26 KKSKKNQQEKSNKKSSTMTKLESVNT-----LKSTLQI-DTTNSSYSNSSSSSSSSSSPSSSSLSSNGSPSSNKKKRTKPNLTIKTtnnaSSNGSRKCN 118
                 22322222222222222222222222.....1111111.222222233333333333333344444443333333333333222221111223333333 PP

       SR-25 116 akekakaeaaaaealpgps 134
                 a+    +e++ +e+l+g +
  EFC39899.1 119 ANFVIPKEHHLTEHLSGDV 137
                 3334555566666666655 PP

>> MAP65_ASE1  Microtubule associated protein (MAP65/ASE1 family)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9  13.9   6.9e-06    0.0082     399     524 ..       7     119 ..       6     138 .. 0.53

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 6.9e-06
                 ETTEEHHHHHHHHHHHHH...HHHHHHHHHHHHHHHHHHHHHHHCXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXX CS
  MAP65_ASE1 399 vdGeklleiieeqweeleekyqererqksarklkkasqteeeilkgskmrtpskrrvtapkTPsklksmskvsssssslkktpsnskslsankntalst 497
                 +++e ++++i + ++++ +k  ++++q++++k+ +++++  e +++ k      ++ ++  T s+ +++s+ ssssss    ps+s ++s+       +
  EFC39899.1   7 FHDEAFTSVILKFQNLFTSKKSKKNQQEKSNKKSSTMTKL-ESVNTLK------STLQIDTTNSSYSNSSSSSSSSSS----PSSSSLSSN----GSPS 90 
                 99****************9999998888888666666665.3333322......334444454443333333333333....443333332....2333 PP

                 XXXXXXXXXXXXXXXX.XXX....XXXXX CS
  MAP65_ASE1 498 anerkrklpsanvisk.nsa.agrakrsl 524
                  n++kr+ p+ ++    n++ +g++k + 
  EFC39899.1  91 SNKKKRTKPNLTIKTTnNASsNGSRKCNA 119
                 34455555555543332222333333332 PP

>> Chorion_2  Chorion family 2
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.8   5.3   1.6e-05     0.019      39      90 ..      61     114 ..      18     120 .. 0.68

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 1.6e-05
   Chorion_2  39 sgrrygdsspsdseaislaklalAapeagsyev..eaeprrrikgsyngpsrgy 90 
                  +++y++ss+s+s+++s ++++l++  + s ++    +p   ik  +n++s+g 
  EFC39899.1  61 TNSSYSNSSSSSSSSSSPSSSSLSSNGSPSSNKkkRTKPNLTIKTTNNASSNGS 114
                 688888888888888888877777655444333004455556777777777654 PP

>> Sec62  Translocation protein Sec62
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   6.1   0.00025       0.3      21      89 ..      25     109 ..      12     122 .. 0.49

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00025
       Sec62  21 kkkskkkkeklkevkkkekaekvfkelkksqlalrveklkekekkkkkee................kkkkkkkkkkvkleieeeq 89 
                 +kkskk++++++++k+++ ++ ++ ++ ks+l++++++++ +++++++++                ++kkk++k ++++++++++
  EFC39899.1  25 SKKSKKNQQEKSNKKSSTMTKLESVNTLKSTLQIDTTNSSYSNSSSSSSSssspsssslssngspsSNKKKRTKPNLTIKTTNNA 109
                 3333333333333333333333333333444444444443333333222234566788999999555555555555555555554 PP

>> Apt1  Golgi-body localisation protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.8  14.8   0.00027      0.33     295     388 ..      22     106 ..       1     139 [. 0.38

  Alignments for each domain:
  == domain 1  score: 9.8 bits;  conditional E-value: 0.00027
        Apt1 295 iFPkrdsdaqeasmvkessseeddesdeesessssss............ssssssassssssssrssslelrlkptsstssssssessssssskkrsse 381
                 +F  ++s+++++         e++++++++ ++ +s+            +ss s++ssssssss++ss++l+            s+ s ss +kkr++ 
  EFC39899.1  22 LFTSKKSKKNQQ---------EKSNKKSSTMTKLESVntlkstlqidttNSSYSNSSSSSSSSSSPSSSSLS------------SNGSPSSNKKKRTKP 99 
                 444333333333.........122222222222222222222222222222333333333333333333333............333333333222222 PP

        Apt1 382 essless 388
                 + +++++
  EFC39899.1 100 NLTIKTT 106
                 2222211 PP

>> Macoilin  Macoilin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.7  19.1   0.00048      0.57     292     392 ..      25     123 ..       7     141 .. 0.53

  Alignments for each domain:
  == domain 1  score: 8.7 bits;  conditional E-value: 0.00048
    Macoilin 292 kskskrlsksessgsesellveesvkskssssssssnknskkasagsagssnssskkhsessksvtsssssknskkqklpaGkssaalkdaaenslpnn 390
                   ksk+ ++++s++++s++++ esv+  +s+ + ++  ns+ ++++s++ss+ss+ + s ss+  +ss+++k   k +l+   +++a+ +   ++ +n 
  EFC39899.1  25 SKKSKKNQQEKSNKKSSTMTKLESVNTLKSTLQIDT-TNSSYSNSSSSSSSSSSPSSSSLSSNGSPSSNKKK-RTKPNLTIKTTNNASSNGSRKCNANF 121
                 334444445555666666777777777777666654.44444444455566666666666666655555444.35554443333333333333333333 PP

    Macoilin 391 ql 392
                  +
  EFC39899.1 122 VI 123
                 33 PP

>> Hid1  High-temperature-induced dauer-formation protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.2  11.4   0.00049      0.59     600     696 ..      25     118 ..      12     139 .. 0.65

  Alignments for each domain:
  == domain 1  score: 8.2 bits;  conditional E-value: 0.00049
        Hid1 600 eenssessrieesrsesrspslsevpelksslaitddeskaereksatessssqavsqlremsekarakesaesteesrqesatskkspsgmsqsae 696
                 +++s+++++ ++++++s   +l++v++lks+l+i   +s+ +++ s+++ssss++ s   ++s+++   ++++++++ +   +t ++  s+ s++ +
  EFC39899.1  25 SKKSKKNQQEKSNKKSSTMTKLESVNTLKSTLQIDTTNSSYSNSSSSSSSSSSPSSS---SLSSNGSPSSNKKKRTKPNLTIKTTNNASSNGSRKCN 118
                 34455555556666777778899999*********9999999999999988888666...4444444444444444444443333333333334433 PP

>> NUC194  NUC194 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3  10.5   0.00082      0.98     196     261 ..      28      95 ..      13     121 .. 0.66

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.00082
      NUC194 196 areaaeveaeesqsksykylssqyladssLsedisqydfsssveqsfssssssen...sassdsqseek 261
                 + +++++e+++++s+ ++ l+s +  +s+L+ d ++  +s+s ++s+ssss s++   s+ s s++++k
  EFC39899.1  28 S-KKNQQEKSNKKSSTMTKLESVNTLKSTLQIDTTNSSYSNSSSSSSSSSSPSSSslsSNGSPSSNKKK 95 
                 3.3455666666889999*********************999944444444443322222222333333 PP

>> CDK2AP  Cyclin-dependent kinase 2-associated protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.0  12.4    0.0012       1.4      25     103 ..      28     110 ..      21     122 .. 0.47

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.0012
      CDK2AP  25 gkkkeersqvqefynyqqqreqkeqqprveItaisssrgss..agsgassgsnsasdyatssgslrkrdrqq...skqqsaaal 103
                 +kk+++++ ++    +++ +++++ +  ++I   +ss ++s  ++s++ss+ +s+s ++++s s++k++r++   + +++++a 
  EFC39899.1  28 SKKNQQEKSNKKSSTMTKLESVNTLKSTLQIDTTNSSYSNSssSSSSSSSP-SSSSLSSNGSPSSNKKKRTKpnlTIKTTNNAS 110
                 344444444444444555555555566666666555555551033333333.23333444445555555555434444444443 PP

>> FAM70  FAM70 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.7   6.1    0.0018       2.2     223     314 ..      24     112 ..       6     127 .. 0.64

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.0018
       FAM70 223 Plaqaesaeseaappkvlyepaqqilsyagfyesapalppysaydlqlqslfpasepsgesdlslsedaqppsqs..asqssasylltsnappl 314
                   ++  s ++++++++ ++++  +  s+++++++ +   + s+y    +s +++s+ps+   +sls++  p s+    ++ + +   t+na+++
  EFC39899.1  24 TSKK--SKKNQQEKSNKKSSTMTKLESVNTLKSTLQIDTTNSSYSNSSSSSSSSSSPSS---SSLSSNGSPSSNKkkRTKPNLTIKTTNNASSN 112
                 3333..355556666677778888999999999999999999**999999999999999...55555544443330033333444444444443 PP

>> PAP1  Transcription factor PAP1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.2  21.9     0.003       3.6      90     185 ..      26     114 ..       8     128 .. 0.41

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.003
        PAP1  90 tkednnnys.nsaanegltrgstassaesqsstysansgtstssdSPsssseshqgqlSScgTSPEPstqSPaakksketsstieeeevahttidge 185
                 +k+++n+++ ++++++ +t+     s ++ +st ++++ +s+ s+S ssss+s+    SS+  S   s +S ++k++k +  ti+  + a   ++g+
  EFC39899.1  26 KKSKKNQQEkSNKKSSTMTKL---ESVNTLKSTLQIDTTNSSYSNSSSSSSSSS--SPSSSSLSSNGSPSSNKKKRTKPNL-TIKTTNNA--SSNGS 114
                 222222222122222222222...223333444444444444433333333333..2233333333333344444433343.44444443..44444 PP

>> Miga  Mitoguardin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.5  12.0     0.003       3.6      68     143 ..      25     107 ..       5     131 .. 0.42

  Alignments for each domain:
  == domain 1  score: 6.5 bits;  conditional E-value: 0.003
        Miga  68 sekksrssssksndtlslasskassssa...........klsgslqslasvksvnsssssaaan.saswdkeeeeelklenitvltpe 143
                 s+k+++++++ksn++ s++++ +s ++            ++s+s+ s +s +s +sss s++++ s++ +k+++      n+t  t++
  EFC39899.1  25 SKKSKKNQQEKSNKKSSTMTKLESVNTLkstlqidttnsSYSNSSSSSSSSSSPSSSSLSSNGSpSSNKKKRTK-----PNLTIKTTN 107
                 11111222222222222211111111111122333333355555555555555555555555532222222222.....222222222 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5   7.7    0.0036       4.3     112     175 ..      29      93 ..      14     113 .. 0.51

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.0036
       Shisa 112 kkkqrekrpgrenlssalaevgpivtettsattvvhsrysepqqssssssypgat...nqgyqpvpv 175
                 kk q+ek+++++++ + l +v++ +   t +   ++s+ys++++ssssss+p ++    +g ++++ 
  EFC39899.1  29 KKNQQEKSNKKSSTMTKLESVNTLKS--TLQIDTTNSSYSNSSSSSSSSSSPSSSslsSNGSPSSNK 93 
                 23333333444444444444444333..444444555565555555555555555442444443333 PP

>> FAM220  FAM220 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.0  19.7     0.027        32      10     139 ..      25     147 ..      20     152 .. 0.60

  Alignments for each domain:
  == domain 1  score: 4.0 bits;  conditional E-value: 0.027
      FAM220  10 srlsvkdsdeeDlsqdslklttklkkrsqkesvspsdapswtaqsvldsnkrsrakeakslekksalskasllkhskkkvlPplkessrrssasassss 108
                 s++s k+++e+     s+k++  + k  + +    + + + t++s  +s ++s ++++ s   +s +s+ s++  +kk   P l++ ++++ +s+ +s+
  EFC39899.1  25 SKKSKKNQQEK-----SNKKSSTMTKLESVNTLKSTLQIDTTNSSYSNSSSSSSSSSSPS--SSSLSSNGSPSSNKKKRTKPNLTIKTTNNASSN-GSR 115
                 45555555554.....44444444433333334344444777777777775555544444..444446778888888889999999888865555.555 PP

      FAM220 109 kavslssapkkenf.dsvlcyideavvsdWLe 139
                 k  + +++pk++++ ++ +  + + v  dW  
  EFC39899.1 116 KCNANFVIPKEHHLtEHLSGDVIQDVFLDWVY 147
                 55666688887776256667788888888875 PP

>> Herpes_pp85  Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.5  13.7    0.0039       4.7     474     515 ..      55      99 ..      21     112 .. 0.78

  Alignments for each domain:
  == domain 1  score: 5.5 bits;  conditional E-value: 0.0039
  Herpes_pp85 474 vfrrpvtdaaasssassssssasPnsvslpsdrssst...rtrvP 515
                   ++   t++  s s ssssss sP+s sl s+ s s    +++ P
   EFC39899.1  55 TLQIDTTNSSYSNSSSSSSSSSSPSSSSLSSNGSPSSnkkKRTKP 99 
                  56667899999********************99987756533333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (155 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2988  (0.166657); expected 358.6 (0.02)
Passed bias filter:                      716  (0.0399353); expected 358.6 (0.02)
Passed Vit filter:                       117  (0.00652574); expected 17.9 (0.001)
Passed Fwd filter:                        18  (0.00100396); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              15  [number of targets reported over threshold]
# CPU time: 0.52u 0.29s 00:00:00.81 Elapsed: 00:00:00.44
# Mc/sec: 1069.57
//
Query:       EFC39900.1  [L=408]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.058   13.2   1.7       0.92    9.4   0.0    3.1  3  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0      0.14   2.5e+03      12      22 ..      54      64 ..      48      65 .. 0.69
   2 ?    1.0   0.2     0.022   3.9e+02       8      14 ..     100     106 ..      95     111 .. 0.88
   3 ?    9.4   0.0   5.1e-05      0.92      11      27 ..     183     200 ..     180     202 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 0.14
      RCC1_2 12 caLtedGeVlc 22
                ++L+ed+e++ 
  EFC39900.1 54 LILSEDDELFV 64
                45778998886 PP

  == domain 2  score: 1.0 bits;  conditional E-value: 0.022
      RCC1_2   8 dyHscaL 14 
                 +yH+c+L
  EFC39900.1 100 SYHACVL 106
                 69****7 PP

  == domain 3  score: 9.4 bits;  conditional E-value: 5.1e-05
      RCC1_2  11 sca.LtedGeVlcWGsNs 27 
                 +c+ +t+ G+++++GsN 
  EFC39900.1 183 ACSfITSHGRLFACGSNQ 200
                 67779************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (408 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       610  (0.0340231); expected 358.6 (0.02)
Passed bias filter:                      456  (0.0254337); expected 358.6 (0.02)
Passed Vit filter:                        31  (0.00172904); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.63u 0.29s 00:00:00.92 Elapsed: 00:00:00.51
# Mc/sec: 2396.53
//
Query:       EFC39901.1  [L=211]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
       0.02   14.1   3.6      0.025   13.8   3.6    1.3  1  CitMHS    Citrate transporter
          1    7.6  14.3        1.1    7.5  14.3    1.2  1  DUF2070   Predicted membrane protein (DUF2070)


Domain annotation for each model (and alignments):
>> CitMHS  Citrate transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   3.6   2.7e-06     0.025      37     108 ..      76     166 ..      28     209 .. 0.78

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.7e-06
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxx...........xxxxxxxxxxxx....xxxxxxxxxxxxxxxxx.......xxxxxxxxxxxxxx RF
      CitMHS  37 iillllgamiigaaleetGlfdrlaakll...........rlaggkrdllvl....lvlltallsafvsndgv.......vlimipivlslakr 108
                 ii++l+  m +++  +  G+f +l+++ l           +++  kr+ +++    ++ + +ll  fvsn+ +       +   i  + ++ k 
  EFC39901.1  76 IIFTLFTCMAYFNTFTNIGIFSYLVQFALgfcmlilqfwlSKVVQKRKYFAIscilIFTGLFLLRVFVSNTLTqyflafvF---ILFITPVSKF 166
                 78**************************************55555666566667655666678889999999999995553...4444444332 PP

>> DUF2070  Predicted membrane protein (DUF2070)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.5  14.3   0.00012       1.1      67     175 ..      60     163 ..      20     206 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.5 bits;  conditional E-value: 0.00012
     DUF2070  67 tykrslflalltelivviisllaillsall.qalvllalvlslalvfalrllvlvavsdesllkavlpaliqpllailllvlyfspesfllllllslif 164
                 + +r +++ + ++ +++i++l+ +++++ + +++ ++++++ +al f + +l +++    + +k+ +++ i  +++++ll ++      +   l+  ++
  EFC39901.1  60 NFQRVFVFEYQSLNYFIIFTLFTCMAYFNTfTNIGIFSYLVQFALGFCMLILQFWLSKVVQKRKYFAISCILIFTGLFLLRVF------VSNTLTQYFL 152
                 5667778888888899999999999999999***********************************99888888887777777......4555555555 PP

     DUF2070 165 alavylfivvv 175
                 a +++lfi+ v
  EFC39901.1 153 AFVFILFITPV 163
                 55555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (211 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1382  (0.0770818); expected 358.6 (0.02)
Passed bias filter:                      370  (0.020637); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.57u 0.31s 00:00:00.87 Elapsed: 00:00:00.51
# Mc/sec: 1254.35
//
Query:       EFC39902.1  [L=417]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    2.2e-27   94.8  17.1    1.7e-08   34.4   0.1    6.2  6  Kelch_4   Galactose oxidase, central domain
    1.8e-17   63.2  15.3    0.00029   21.0   0.1    6.1  6  Kelch_3   Galactose oxidase, central domain
    3.5e-15   55.7  10.9      0.017   15.4   0.3    5.4  5  Kelch_6   Kelch motif
    2.5e-14   52.9  11.5    0.00032   20.6   0.2    6.0  6  Kelch_5   Kelch motif
    1.1e-09   37.9   7.7      0.024   14.6   0.1    4.8  4  Kelch_2   Kelch motif
    1.7e-08   33.9  16.8     0.0053   16.3   0.2    5.3  6  Kelch_1   Kelch motif
  ------ inclusion threshold ------
      0.014   15.2   1.7      0.042   13.7   1.7    1.8  1  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> Kelch_4  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.3   0.2   3.3e-07   0.00086       4      44 ..      84     122 ..      83     126 .. 0.91
   2 !   11.8   0.2   7.2e-05      0.19       2      41 ..     132     173 ..     131     186 .. 0.88
   3 !   27.6   0.1   8.2e-10   2.1e-06      11      45 ..     202     234 ..     191     238 .. 0.82
   4 !    7.8   0.1    0.0013       3.3       1      43 [.     242     289 ..     242     297 .. 0.76
   5 !   34.4   0.1   6.5e-12   1.7e-08       6      44 ..     304     342 ..     299     349 .. 0.90
   6 ?    1.7   0.0       0.1   2.6e+02       4      24 ..     351     373 ..     350     382 .. 0.71

  Alignments for each domain:
  == domain 1  score: 19.3 bits;  conditional E-value: 3.3e-07
     Kelch_4   4 ghsatsipdgtiylfGGrgedgtllndlylldlstntW.rrl 44 
                 +h++++  dg +y +GGr+e +   + ++++dl t tW +++
  EFC39902.1  84 SHTCVVHHDGIVYFWGGRNETN---GKIHRFDLRTYTWmKPI 122
                 6*******************98...9************7766 PP

  == domain 2  score: 11.8 bits;  conditional E-value: 7.2e-05
     Kelch_4   2 Raghsatsipdg.tiylfGGrgedg.tllndlylldlstntW 41 
                 R +h++t   ++  +++fGG  ++  + +ndl + d  t +W
  EFC39902.1 132 RYYHGFTKQENDpIFWMFGGLDNQEsKYYNDLIRVDGRTCQW 173
                 8899999997777***********77******9999999999 PP

  == domain 3  score: 27.6 bits;  conditional E-value: 8.2e-10
     Kelch_4  11 pdgtiylfGGrgedgtllndlylldlstntWrrlg 45 
                  + ++ lfGG+g+  ++++d++ +++s ++W++l+
  EFC39902.1 202 SNHSLLLFGGCGD--ESYSDVWEFNISLRKWTKLA 234
                 4579*********..69****************96 PP

  == domain 4  score: 7.8 bits;  conditional E-value: 0.0013
     Kelch_4   1 pRaghsatsi..pd.gtiylfGGrgedg..tllndlylldlstntWrr 43 
                 pR++ s +    ++ + ++++GG  + +  tl n l++l+lst  W++
  EFC39902.1 242 PRGYSSGILMkkDNtDVLVIYGGDIGVDnqTLTNQLCILNLSTLVWKT 289
                 667777777654224899999997665568*************99986 PP

  == domain 5  score: 34.4 bits;  conditional E-value: 6.5e-12
     Kelch_4   6 satsipdgtiylfGGrgedgtllndlylldlstntWrrl 44 
                 +++ i +++ ++fGG+++d  +++d y+++l+ ntW+ l
  EFC39902.1 304 TTCKISNDEMFIFGGCNDDYIPYSDSYIYNLKYNTWTLL 342
                 677889******************************976 PP

  == domain 6  score: 1.7 bits;  conditional E-value: 0.1
     Kelch_4   4 ghsatsi..pdgtiylfGGrged 24 
                 ++s++ i   +g i l+GG+ e+
  EFC39902.1 351 NCSSIFIdeERGIINLYGGYDEQ 373
                 566666634459999*****996 PP

>> Kelch_3  Galactose oxidase, central domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    5.7   0.1    0.0074        19      13      45 ..     100     136 ..      95     138 .. 0.74
   2 !   13.7   0.3   2.2e-05     0.056       4      44 ..     146     195 ..     146     198 .. 0.82
   3 !   21.0   0.1   1.1e-07   0.00029       1      37 [.     203     236 ..     203     248 .. 0.86
   4 !   13.7   0.1   2.2e-05     0.057       2      48 ..     257     305 ..     256     306 .. 0.88
   5 !   14.9   0.1   9.7e-06     0.025       1      33 [.     310     341 ..     310     354 .. 0.84
   6 ?   -0.5   0.0      0.67   1.7e+03       6      18 ..     366     378 ..     366     386 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.7 bits;  conditional E-value: 0.0074
     Kelch_3  13 dgqdrlndvyvydldtntWaeiaslpp....aRagha 45 
                 ++++ ++  +++dl t tW +  s++      R++h 
  EFC39902.1 100 GRNETNGKIHRFDLRTYTWMKPISSNLdkkdSRYYHG 136
                 35688899************88665554555777775 PP

  == domain 2  score: 13.7 bits;  conditional E-value: 2.2e-05
     Kelch_3   4 lyifGGlgddgqdrlndvyvydl.....dtntWaei....aslppaRagh 44 
                 ++ fGGl+ +  +++nd+ ++d      ++++++e     +++p+ R+gh
  EFC39902.1 146 FWMFGGLDNQESKYYNDLIRVDGrtcqwNWEQFTEPtdgnSEWPSRRRGH 195
                 589*****7779999*******98874444466666789999*******9 PP

  == domain 3  score: 21.0 bits;  conditional E-value: 1.1e-07
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWaeiasl 37 
                 +++l++fGG+g    ++++dv++++++  +W+++a++
  EFC39902.1 203 NHSLLLFGGCG---DESYSDVWEFNISLRKWTKLATT 236
                 5789*******...8*****************99765 PP

  == domain 4  score: 13.7 bits;  conditional E-value: 2.2e-05
     Kelch_3   2 drlyifGGlgd.dgqdrlndvyvydldtntWaeiasl.ppaRaghaata 48 
                 d l+i+GG  + d+q+ +n++  ++l+t  W++ +++ +p+  gha+t+
  EFC39902.1 257 DVLVIYGGDIGvDNQTLTNQLCILNLSTLVWKTYDNSiTPPLFGHAGTT 305
                 778899997778**********************886488*****9985 PP

  == domain 5  score: 14.9 bits;  conditional E-value: 9.7e-06
     Kelch_3   1 gdrlyifGGlgddgqdrlndvyvydldtntWae 33 
                 +d+++ifGG++dd   +++d y y+l  ntW+ 
  EFC39902.1 310 NDEMFIFGGCNDD-YIPYSDSYIYNLKYNTWTL 341
                 699********65.99***********99**94 PP

  == domain 6  score: -0.5 bits;  conditional E-value: 0.67
     Kelch_3   6 ifGGlgddgqdrl 18 
                 ++GG++ ++++ +
  EFC39902.1 366 LYGGYDEQRRTDT 378
                 79****9888765 PP

>> Kelch_6  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.4   0.3   6.5e-06     0.017       4      40 ..      84     118 ..      81     119 .. 0.84
   2 !   15.2   0.1   7.9e-06      0.02      14      40 ..     146     173 ..     131     183 .. 0.84
   3 !   10.7   0.0    0.0002       0.5      12      44 ..     204     234 ..     194     243 .. 0.84
   4 !    9.8   0.0   0.00039         1      14      43 ..     259     290 ..     250     298 .. 0.86
   5 !    7.8   0.1    0.0017       4.4       6      43 ..     304     342 ..     299     351 .. 0.77

  Alignments for each domain:
  == domain 1  score: 15.4 bits;  conditional E-value: 6.5e-06
     Kelch_6   4 ghslvsvggki.YifGGytdsspylnkvwvydpetksW 40 
                 +h++v++ + i Y +GG++    +  k++++d++t +W
  EFC39902.1  84 SHTCVVHHDGIvYFWGGRNE---TNGKIHRFDLRTYTW 118
                 799999666652777***98...9***********999 PP

  == domain 2  score: 15.2 bits;  conditional E-value: 7.9e-06
     Kelch_6  14 iYifGGytds.spylnkvwvydpetksW 40 
                 +++fGG++++ s+y+n++++ d +t+ W
  EFC39902.1 146 FWMFGGLDNQeSKYYNDLIRVDGRTCQW 173
                 589**********************997 PP

  == domain 3  score: 10.7 bits;  conditional E-value: 0.0002
     Kelch_6  12 gkiYifGGytdsspylnkvwvydpetksWeqlp 44 
                  ++ +fGG +d  +++++vw ++++ ++W++l+
  EFC39902.1 204 HSLLLFGGCGD--ESYSDVWEFNISLRKWTKLA 234
                 56888988888..8999*************987 PP

  == domain 4  score: 9.8 bits;  conditional E-value: 0.00039
     Kelch_6  14 iYifGGytds..spylnkvwvydpetksWeql 43 
                 ++i+GG  +    + +n++++++++t +W++ 
  EFC39902.1 259 LVIYGGDIGVdnQTLTNQLCILNLSTLVWKTY 290
                 6889999888899****************985 PP

  == domain 5  score: 7.8 bits;  conditional E-value: 0.0017
     Kelch_6   6 slvs.vggkiYifGGytdsspylnkvwvydpetksWeql 43 
                 +++   ++  +ifGG +d+  ++++ ++y+++ ++W+ l
  EFC39902.1 304 TTCKiSNDEMFIFGGCNDDYIPYSDSYIYNLKYNTWTLL 342
                 55552345789********6666666**********987 PP

>> Kelch_5  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.4   0.1    0.0002       0.5       7      40 ..      85     114 ..      84     116 .. 0.80
   2 ?    4.5   0.1     0.014        37       5      35 ..     132     164 ..     130     167 .. 0.70
   3 !   16.9   0.0   1.8e-06    0.0047       1      39 [.     188     225 ..     188     226 .. 0.84
   4 ?    3.2   0.1     0.037        94      17      41 ..     259     284 ..     241     285 .. 0.79
   5 !   20.6   0.2   1.2e-07   0.00032       3      40 ..     296     335 ..     296     336 .. 0.91
   6 ?   -0.9   0.0      0.68   1.7e+03      19      24 ..     366     371 ..     352     381 .. 0.83

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 0.0002
     Kelch_5   7 ghcavtvsekiYvyGGkvgrdgsvsddvyvLdlp 40 
                 + c+v +++ +Y++GG++    + +++++++dl+
  EFC39902.1  85 HTCVVHHDGIVYFWGGRN----ETNGKIHRFDLR 114
                 689***************....666666666665 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.014
     Kelch_5   5 Raghcavtvsek..iYvyGGkvgrdgsvsddvy 35 
                 R++h + + ++    +++GG + +++++++d+ 
  EFC39902.1 132 RYYHGFTKQENDpiFWMFGGLDNQESKYYNDLI 164
                 66666666543332368*****889999**986 PP

  == domain 3  score: 16.9 bits;  conditional E-value: 1.8e-06
     Kelch_5   1 iPppRaghcavtv..sekiYvyGGkvgrdgsvsddvyvLdl 39 
                 +P+ R+gh + +   +++++++GG +   +++++dv+ +++
  EFC39902.1 188 WPSRRRGHVFLYResNHSLLLFGGCG---DESYSDVWEFNI 225
                 588888888887644599********...********9985 PP

  == domain 4  score: 3.2 bits;  conditional E-value: 0.037
     Kelch_5  17 iYvyGGkvg.rdgsvsddvyvLdlps 41 
                 + +yGG +g  ++ +++ + +L+l +
  EFC39902.1 259 LVIYGGDIGvDNQTLTNQLCILNLST 284
                 667****************9999975 PP

  == domain 5  score: 20.6 bits;  conditional E-value: 1.2e-07
     Kelch_5   3 ppRaghcavtv...sekiYvyGGkvgrdgsvsddvyvLdlp 40 
                 pp++gh+  t+   +++++++GG +  d ++++d y+++l+
  EFC39902.1 296 PPLFGHAGTTCkisNDEMFIFGGCN-DDYIPYSDSYIYNLK 335
                 699********6655**********.699*********985 PP

  == domain 6  score: -0.9 bits;  conditional E-value: 0.68
     Kelch_5  19 vyGGkv 24 
                 +yGG++
  EFC39902.1 366 LYGGYD 371
                 7****9 PP

>> Kelch_2  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.5   0.3   9.9e-06     0.025       4      42 ..      84     118 ..      82     121 .. 0.92
   2 !   14.6   0.1   9.2e-06     0.024       9      46 ..     201     234 ..     191     237 .. 0.85
   3 !    9.1   0.1   0.00052       1.3       3      45 ..     302     342 ..     300     345 .. 0.79
   4 ?   -0.4   0.0      0.52   1.3e+03       8      20 ..     358     370 ..     351     381 .. 0.70

  Alignments for each domain:
  == domain 1  score: 14.5 bits;  conditional E-value: 9.9e-06
     Kelch_2   4 ghsssvp.ggkiyvvGGahtdnpnlsssdvhvldlekhvW 42 
                  h+++v  +g +y++GG+     n+   ++h +dl++++W
  EFC39902.1  84 SHTCVVHhDGIVYFWGGR-----NETNGKIHRFDLRTYTW 118
                 58999888**********.....999999*********** PP

  == domain 2  score: 14.6 bits;  conditional E-value: 9.2e-06
     Kelch_2   9 vpggkiyvvGGahtdnpnlsssdvhvldlekhvWeevt 46 
                  +++ ++++GG     +++s sdv+ ++ + ++W++++
  EFC39902.1 201 ESNHSLLLFGGC----GDESYSDVWEFNISLRKWTKLA 234
                 5699********....*******************986 PP

  == domain 3  score: 9.1 bits;  conditional E-value: 0.00052
     Kelch_2   3 gghsssvpggkiyvvGGahtdnpnlsssdvhvldlekhvWeev 45 
                 +g+++  +++ ++++GG  +d+   + sd ++++l+ ++W+++
  EFC39902.1 302 AGTTCKISNDEMFIFGGC-NDDYIPY-SDSYIYNLKYNTWTLL 342
                 78999999**********.4333344.66679*******9987 PP

  == domain 4  score: -0.4 bits;  conditional E-value: 0.52
     Kelch_2   8 svpggkiyvvGGa 20 
                    +g i ++GG+
  EFC39902.1 358 DEERGIINLYGGY 370
                 455899999**** PP

>> Kelch_1  Kelch motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   10.2   0.4   0.00017      0.45       4      40 ..      85     119 ..      84     120 .. 0.94
   2 ?   -1.4   0.1      0.71   1.8e+03      17      39 ..     149     173 ..     149     174 .. 0.85
   3 !   14.7   0.0   6.5e-06     0.017      11      44 ..     203     235 ..     201     237 .. 0.93
   4 ?   -1.7   0.0      0.88   2.3e+03      14      39 ..     259     287 ..     256     289 .. 0.68
   5 !   16.3   0.2   2.1e-06    0.0053       9      41 ..     308     341 ..     301     343 .. 0.90
   6 ?    0.9   0.0      0.14   3.5e+02      13      28 ..     363     378 ..     361     381 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.2 bits;  conditional E-value: 0.00017
                 SEEEEEETTEEEEEEEBCSSSBEEEEEEEETTTTEEE CS
     Kelch_1   4 gagavvvggkiYviGGsdggnalssvevyDpetntWr 40 
                 + ++v ++g +Y  GG+++      + ++D++t tW 
  EFC39902.1  85 HTCVVHHDGIVYFWGGRNE--TNGKIHRFDLRTYTWM 119
                 789***************9..***************6 PP

  == domain 2  score: -1.4 bits;  conditional E-value: 0.71
                 EEEBCS..SSBEEEEEEEETTTTEE CS
     Kelch_1  17 iGGsdg..gnalssvevyDpetntW 39 
                 +GG d+  +++ +++ + D +t +W
  EFC39902.1 149 FGGLDNqeSKYYNDLIRVDGRTCQW 173
                 7999999999999999988888888 PP

  == domain 3  score: 14.7 bits;  conditional E-value: 6.5e-06
                 TTEEEEEEEBCSSSBEEEEEEEETTTTEEEEECC CS
     Kelch_1  11 ggkiYviGGsdggnalssvevyDpetntWrelps 44 
                 ++ +  +GG+ + ++ s+v+ ++    +W++l++
  EFC39902.1 203 NHSLLLFGGCGD-ESYSDVWEFNISLRKWTKLAT 235
                 788999******.******************986 PP

  == domain 4  score: -1.7 bits;  conditional E-value: 0.88
                 EEEEEEBCS...SSBEEEEEEEETTTTEE CS
     Kelch_1  14 iYviGGsdg...gnalssvevyDpetntW 39 
                 + + GG  g   ++ ++ + ++++ t  W
  EFC39902.1 259 LVIYGGDIGvdnQTLTNQLCILNLSTLVW 287
                 66788888877777777666666666666 PP

  == domain 5  score: 16.3 bits;  conditional E-value: 2.1e-06
                 EETTEEEEEEEBCS.SSBEEEEEEEETTTTEEEE CS
     Kelch_1   9 vvggkiYviGGsdg.gnalssvevyDpetntWre 41 
                   +++++++GG+++ + + s+ ++y+++ ntW+ 
  EFC39902.1 308 ISNDEMFIFGGCNDdYIPYSDSYIYNLKYNTWTL 341
                 6799****************************96 PP

  == domain 6  score: 0.9 bits;  conditional E-value: 0.14
                 EEEEEEEBCSSSBEEE CS
     Kelch_1  13 kiYviGGsdggnalss 28 
                  i   GG+d+++++++
  EFC39902.1 363 IINLYGGYDEQRRTDT 378
                 56779*****999876 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.7   1.7   1.6e-05     0.042       8      26 ..      83     102 ..      78     106 .. 0.83

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 1.6e-05
      RCC1_2   8 dyHscaLtedGeVlcWG.sN 26 
                 d+H+c+++ dG+V+ WG +N
  EFC39902.1  83 DSHTCVVHHDGIVYFWGgRN 102
                 79***************534 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (417 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       561  (0.0312901); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.63u 0.32s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 2369.30
//
Query:       EFC39903.1  [L=318]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    3.8e-24   84.8   8.7    8.6e-23   80.5   5.4    2.2  2  DUF4476         Domain of unknown function (DUF4476)
  ------ inclusion threshold ------
      0.023   14.7   7.1      0.083   12.9   3.3    2.6  3  OMP_b-brl_2     Outer membrane protein beta-barrel domain
       0.18   11.9   7.9       0.45   10.6   7.8    1.6  1  OMP_b-brl       Outer membrane protein beta-barrel domain
       0.71    8.7   4.4       0.81    8.5   0.6    2.1  2  DUF3769         Protein of unknown function (DUF3769)
        7.4    6.8   8.2        4.2    7.6   1.3    3.1  3  Pericardin_rpt  Pericardin like repeat


Domain annotation for each model (and alignments):
>> DUF4476  Domain of unknown function (DUF4476)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.2   0.0    0.0035        13       8      29 ..     196     217 ..     193     227 .. 0.75
   2 !   80.5   5.4   2.4e-26   8.6e-23       2      91 .]     223     316 ..     222     316 .. 0.96

  Alignments for each domain:
  == domain 1  score: 6.2 bits;  conditional E-value: 0.0035
     DUF4476   8 eqlveklkkasfdddklklleq 29 
                 +++++  k+ +fd+dk+k++  
  EFC39903.1 196 QKIIAACKNSTFDSDKVKAVVS 217
                 6788889999999999999874 PP

  == domain 2  score: 80.5 bits;  conditional E-value: 2.4e-26
     DUF4476   2 msdksfeqlveklkkasfdddklklleq.alank..aftcsqvvqllklfsfdddrlkalkllapnivDkqns.etiidsftfssdkkkareil 91 
                 +s+   ++lv++lk + f++d++k+++q +++n+  +++c+ +v++l+++++d+d++k+l++++++i+D+++s eti+ +f+fs+d++kar++l
  EFC39903.1 223 CSPIMAMDLVTILKLFDFANDQVKVINQlKSTNNiaQMSCNDAVSILNVLDMDNDKIKVLDVICSQIYDRRQSaETIVGTFSFSNDQDKARKML 316
                 8899999*********************878888************************************9999*****************986 PP

>> OMP_b-brl_2  Outer membrane protein beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.1     0.025        89      37      67 ..      27      57 ..      10      69 .. 0.79
   2 ?   12.9   3.3   2.3e-05     0.083      23     112 ..      47     144 ..      31     148 .. 0.67
   3 ?   10.0   2.6   0.00019      0.66      12      76 ..     101     167 ..      80     192 .. 0.59

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.025
  OMP_b-brl_2 37 snprlgfsvgvvveyrleegwglqpglgyss 67
                 +  +++++v+++v++  + + ++qp++ +s 
   EFC39903.1 27 VTVSGNVHVQPSVTVSGNVHTTVQPTMTVSA 57
                 556899*******************998875 PP

  == domain 2  score: 12.9 bits;  conditional E-value: 2.3e-05
  OMP_b-brl_2  23 sklsps...aeseensqsnprlgfsvgvvveyrleegwglqpglgy.ssrgmefefeget.nnedkktkitstylelPllakyki..kks.nvrlflf 112
                  ++++p+     s++n +s  + + svg++v +  ++   +qp++g  +s+g+++ + + t  +++++t+++s+y ++ ++ ++ +  + +  v++ ++
   EFC39903.1  47 TTVQPTmtvSASTNNGYSTVSTQPSVGLSVGVSAQPTVHVQPTVGMtVSNGYSTMNAQPTiGMTMNTTTYESNYNTVTMQPTVDMsiGVQpTVGVNMN 144
                  333333444244566666677777777777777778888887776436788888888888889***********999999998875444444555444 PP

  == domain 3  score: 10.0 bits;  conditional E-value: 0.00019
  OMP_b-brl_2  12 leigvkgGfnasklspsaese.ensqsnprlgfsvgv..vveyrleegw.glqpglgyssrgmefefeg 76 
                   + +++ G++++++++  es+ +++ + p++  s+gv   v +++++g+ g+++g++ +   m++++  
   EFC39903.1 101 MNAQPTIGMTMNTTTY--ESNyNTVTMQPTVDMSIGVqpTVGVNMNMGMpGVGIGFNMGMPNMTVSTHT 167
                  4455667777777777..443134455555555544433777777777766777777777777777652 PP

>> OMP_b-brl  Outer membrane protein beta-barrel domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   7.8   0.00013      0.45      28     121 ..      53     168 ..      27     175 .. 0.67

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00013
   OMP_b-brl  28 lglskvkvdgv.gsdsgfgfgvgagyefndnvgvegglsysgdkdysgs..........gktdikinlls............vpvnagyafnlsdsvlp 103
                 +++s  +++g+ ++++ + +g+++g+  ++ v v++ ++ + ++ ys++          ++t++++n+++            v+ ++g+++n++   ++
  EFC39903.1  53 MTVSASTNNGYsTVSTQPSVGLSVGVSAQPTVHVQPTVGMTVSNGYSTMnaqptigmtmNTTTYESNYNTvtmqptvdmsigVQPTVGVNMNMGM-PGV 150
                 444444556664566679************9999****999999999999898888888777777777775555555555444444555555533.456 PP

   OMP_b-brl 104 yggaGlgytkvevdvsgn 121
                  +g+++g  + +v+++ +
  EFC39903.1 151 GIGFNMGMPNMTVSTHTT 168
                 666666655555555444 PP

>> DUF3769  Protein of unknown function (DUF3769)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.9   0.2     0.045   1.6e+02     314     341 ..      54      81 ..      38      90 .. 0.77
   2 ?    8.5   0.6   0.00022      0.81     300     343 ..      97     140 ..      83     144 .. 0.92

  Alignments for each domain:
  == domain 1  score: 0.9 bits;  conditional E-value: 0.045
     DUF3769 314 tgltgvaslYsngdsQssltgsvGlegq 341
                 t   ++ + Ys  ++Q+s+++svG+++q
  EFC39903.1  54 TVSASTNNGYSTVSTQPSVGLSVGVSAQ 81 
                 223456678***************9876 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.00022
     DUF3769 300 rytpepvvpglslvtgltgvaslYsngdsQssltgsvGlegqlG 343
                  y+    +p + +++++t+  s+Y+  + Q+++ +s+G++ ++G
  EFC39903.1  97 GYSTMNAQPTIGMTMNTTTYESNYNTVTMQPTVDMSIGVQPTVG 140
                 5899999*********************************9998 PP

>> Pericardin_rpt  Pericardin like repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.6   1.3    0.0012       4.2       6      30 ..      68      91 ..      61      95 .. 0.89
   2 ?   -2.4   0.0       1.6   5.6e+03      25      30 ..     103     108 ..      96     109 .. 0.64
   3 ?    2.1   0.3     0.061   2.2e+02       5      22 ..     134     149 ..     131     154 .. 0.71

  Alignments for each domain:
  == domain 1  score: 7.6 bits;  conditional E-value: 0.0012
  Pericardin_rpt  6 tQpGvGgqtGigGGQpGYgtQpGvG 30
                    tQp vG + G+ + Qp    Qp vG
      EFC39903.1 68 TQPSVGLSVGV-SAQPTVHVQPTVG 91
                    89999999999.7999999999998 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 1.6
  Pericardin_rpt  25 tQpGvG 30 
                     +Qp +G
      EFC39903.1 103 AQPTIG 108
                     466665 PP

  == domain 3  score: 2.1 bits;  conditional E-value: 0.061
  Pericardin_rpt   5 GtQpGvGgqtGigGGQpG 22 
                     G Qp vG+   +  G pG
      EFC39903.1 134 GVQPTVGVNMNM--GMPG 149
                     788888877766..6666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (318 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       909  (0.0507); expected 358.6 (0.02)
Passed bias filter:                      400  (0.0223102); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.62u 0.36s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 1765.47
//
Query:       EFC39904.1  [L=422]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    1.8e-16   60.3   2.3    4.9e-16   58.9   2.4    1.6  1  EcKinase        Ecdysteroid kinase
    1.5e-09   37.2   5.8    3.3e-08   32.8   5.8    2.1  1  DUF1679         Protein of unknown function (DUF1679)
    3.6e-07   30.4   0.0    5.4e-07   29.8   0.0    1.2  1  APH             Phosphotransferase enzyme family
    0.00015   21.4   1.6    0.00032   20.3   1.6    1.5  1  Choline_kinase  Choline/ethanolamine kinase


Domain annotation for each model (and alignments):
>> EcKinase  Ecdysteroid kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   58.9   2.4   1.1e-19   4.9e-16      37     286 ..      82     346 ..      51     349 .. 0.77

  Alignments for each domain:
  == domain 1  score: 58.9 bits;  conditional E-value: 1.1e-19
    EcKinase  37 eeekrellkslklfkkEiamYekvlP..eleallreagdefklapkcykaeeeee..eevlvleDLkekgyknadRlkgldlehlklvlkkLAkfHAaS 131
                 +  +r++l+++ ++kkEia+Y+ +l   ++++ll     +++++p +y ae +++  +++++   L+++g k  d   g + e ++l+lk+ A      
  EFC39904.1  82 HHVDRDFLAETSAYKKEIAFYQYLLNtnSINNLL-----NRNVVPPVYVAEIDRNnkDQFILI--LRKSG-KALDQIVGCSTELIRLILKEWALIQSEF 172
                 4556888899999999999999888611344555.....5679*****999555443777776..88888.667888********************99 PP

    EcKinase 132 lalkeekpevfkelk......kglleedyvssalkeafeelleellkaalealreelpelekea...................ekleklkenlferlle 205
                   ++e+++++ ++l         +l+ + +s  +k++    +ee+++++ ++ +++++++  +                     + +    ++fe ++e
  EFC39904.1 173 WYTAEDEEKFKAQLVvngydvMTPLHHTVTSMINKKNNILPVEEVVEEVKQVWKDKWEDYH-YVlkyfssqtgmkqlaenalvIDEQVSSGKIFEIVEE 270
                 9999999999889874333222334444445555555555569999999999999999995.4458999997777666654321112223367777777 PP

    EcKinase 206 lveekeeefnvlnHGDlwvnNimfkydeegepedvilvDFQlsrygSpalDLlyflytsteeelrkekfdellriYhesLv 286
                  ++  + + ++lnH D+ + N++   +     e+v +vDFQ + +gS   DL +f+ +++ +e+ +++f +l++ Y++sL+
  EFC39904.1 271 GCQVLTANNRTLNHCDFRLDNMLQVSE-----ESVAFVDFQCIGFGSCGYDLGFFISSCLLSEQVNDNFHNLMESYWNSLI 346
                 7779*****************998776.....46********************************************996 PP

>> DUF1679  Protein of unknown function (DUF1679)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.8   5.8   7.3e-12   3.3e-08     218     376 ..     229     382 ..      59     416 .. 0.89

  Alignments for each domain:
  == domain 1  score: 32.8 bits;  conditional E-value: 7.3e-12
     DUF1679 218 lkkifeqlrkilgaeeeekveelvdiveeylkeililekaskvskvlGi.kkvlvhgDlwsaNiLfseeeegklklkkviDyQlvslgnpaeDlvrlll 315
                  ++    l+   +++  +++ e   +++e + + +i+e + + ++vl   +  l+h D    N+L   ee+      + +D+Q + +g+ + Dl+ ++ 
  EFC39904.1 229 WEDYHYVLKYFSSQTGMKQLAENALVIDEQVSSGKIFEIVEEGCQVLTAnNRTLNHCDFRLDNMLQVSEES-----VAFVDFQCIGFGSCGYDLGFFIS 322
                 5555555666667777888888888999999999***************9999************999777.....799******************** PP

     DUF1679 316 scLsgedRrarkeelLeqyyetflkaledngeepytleqLkdsYklyfplmallllPllgp 376
                 scL  e   ++ ++l+e y+++++ +     e+ y+leqLk   + ++++   l ++++++
  EFC39904.1 323 SCLLSEQVNDNFHNLMESYWNSLICNK-PIIEKTYSLEQLKRETRKAAVIQLSLYMSMFSA 382
                 ***********************9876.66799********99999999888777777764 PP

>> APH  Phosphotransferase enzyme family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   29.8   0.0   1.2e-10   5.4e-07     156     213 ..     272     324 ..     217     343 .. 0.71

  Alignments for each domain:
  == domain 1  score: 29.8 bits;  conditional E-value: 1.2e-10
                 HHHH--SSS-EEEE-SS-SGGGEEEC..TTEEEEE---TT-EEEECCHHHHCCHHHCS CS
         APH 156 laallpgelptvllHgDlhpgNllvdpddgrvtGviDfedaglgpplyDlavllrswt 213
                 +  l +    ++l H+D++++N+l  ++   v +++Df++ g g   yDl++++ s +
  EFC39904.1 272 CQVLTA--NNRTLNHCDFRLDNMLQVSE-ESV-AFVDFQCIGFGSCGYDLGFFISS-C 324
                 444444..789***************44.554.8*****************99944.3 PP

>> Choline_kinase  Choline/ethanolamine kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.3   1.6   7.2e-08   0.00032      84     204 ..     215     338 ..     191     345 .. 0.61

  Alignments for each domain:
  == domain 1  score: 20.3 bits;  conditional E-value: 7.2e-08
                     .TTSSSS-HHHH.HHHHH........HHCCS.TT..ECHHGGCCHCCCTHHHHHHHHHTHHHHHH.CHGG-EEEE-S--SGGGEEE.-CTTEEEE CS
  Choline_kinase  84 eseskespslwk.tmqkw........llnkeaqtkakkekkkkqlklinledlekelekleklle.elespvvfcHnDlqegNillnkeekklvl 168
                     e+ ++e +++wk +++++         + + +q+ ++    ++q+++ ++ ++      +e+ ++  + ++ ++ H+D    N+l+  +e+++ +
      EFC39904.1 215 EEVVEEVKQVWKdKWEDYhyvlkyfsSQTGMKQLAENALVIDEQVSSGKIFEI------VEEGCQvLTANNRTLNHCDFRLDNMLQ-VSEESVAF 302
                     55566666777523444454433222222223333333333333333333333......3333323466778999**********9.9999**** PP

                     --GTT-EEEEHHHHHHHHHHHTTEEHHHCSTSHEE- CS
  Choline_kinase 169 IDFEYagynyrgfDlanhfiEwagdyeeeeaffkld 204
                     +DF   g+  +g+Dl+ +++   ++++ ++ f++l 
      EFC39904.1 303 VDFQCIGFGSCGYDLGFFISSCLLSEQVNDNFHNLM 338
                     ******************999988777776666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (422 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       990  (0.0552178); expected 358.6 (0.02)
Passed bias filter:                      570  (0.0317921); expected 358.6 (0.02)
Passed Vit filter:                        40  (0.00223102); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 2433.99
//
Query:       EFC39905.1  [L=356]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     0.0002   20.3   3.5    0.00026   19.9   3.5    1.2  1  DUF2207   Predicted membrane protein (DUF2207)
  ------ inclusion threshold ------
      0.023   15.4  16.2      0.062   14.0  16.2    1.8  1  GRP       Glycine rich protein family
      0.041   14.1   0.1      0.069   13.4   0.1    1.3  1  Shisa     Wnt and FGF inhibitory regulator


Domain annotation for each model (and alignments):
>> DUF2207  Predicted membrane protein (DUF2207)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.9   3.5   4.4e-08   0.00026       2     254 ..      34     269 ..      33     323 .. 0.69

  Alignments for each domain:
  == domain 1  score: 19.9 bits;  conditional E-value: 4.4e-08
     DUF2207   2 IesydvdatvqedG.sldvtEtitydfdgsrhgiyrdrdlplr....................tydvdgsgnsvrikirddvtepyykessddgtlstg 79 
                 I+s  ++++  e G s+ ++E ++y+f+gs+  i   r++p +                     +   +sg+++++ +  +   p +++++ ++     
  EFC39905.1  34 ISSIVSNIQFLEKGsSMNIVEDFEYNFNGSYSRIG--RPIPRDiatsvdplsikvfisdstysISSKLESGSESYFIV--STLSPATPSNALTK----- 123
                 55566666666555279******************..88854444445555565555555544333333444444444..22245555555555..... PP

     DUF2207  80 thtyeisYtvknavtkykdvaelywnvigngwdvpienvtitvtlPseaksggdlrawlHg.ldgsttvkkddgsvtftarnlppgeglevrvlf.... 173
                    ++is+ + + +++  d+    w +  +++   i++++ t+ +       +++  +  + ++g++++ +++ + tf++  l+++++   ++ +    
  EFC39905.1 124 -FSFRISFSLIPNLEVSTDTV---WRYHYQDN-SFISSISTTILFD------SSISSYNLTcVNGQVSTIDNQYKATFNMTGLNSNSYFKPEIKIiglg 211
                 .9******************9...88888877.78********997......2333333346889999999999*********************7764 PP

     DUF2207 174 ..ptnnarktsgnkldeilkeeqkntreraarlslallillilllilllllllllliklllwkkygrepkvkevdpeYer.dvP 254
                                          +++ + +   + li++++++i+l+ ++ + ++k    k++g    +k+ +  + r dvP
  EFC39905.1 212 tsM----------------------KSDFYFQAIGIPLIIVGVIAIILIGAVTIYFLK----KNWGTSSVYKPSVSAHPRvDVP 269
                 321......................344555555555555555555555555555555....6677777777765555555666 PP

>> GRP  Glycine rich protein family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.0  16.2     1e-05     0.062      43      78 ..     318     350 ..     271     355 .. 0.54

  Alignments for each domain:
  == domain 1  score: 14.0 bits;  conditional E-value: 1e-05
         GRP  43 ekyggggkhggGgygggggggngGGGykgggGgygg 78 
                   ++ gg++ggG y+gggg+ +gGGG   ggG ygg
  EFC39905.1 318 SYDYSGGYGGGGDYSGGGGYDYGGGG---GGGDYGG 350
                 22233344455555555555555554...3333433 PP

>> Shisa  Wnt and FGF inhibitory regulator
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.1   1.2e-05     0.069      80     181 ..     216     316 ..     178     322 .. 0.73

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.2e-05
       Shisa  80 kdiyvpvlivktifivfvivgvvvivcccgclkkkqrekrpgrenlssalaev.gpivtettsattvvhsrysepqqssssssypgatnqgyqpvpv.. 175
                 +d   + +i+  ++iv vi ++++  + +  lkk   +++   ++  sa   v  p+ t  t+ +t v+ +  +  +s  ++s +  ++ gy++ +v  
  EFC39905.1 216 SD-FYFQAIGIPLIIVGVIAIILIGAVTIYFLKKNWGTSSV-YKPSVSAHPRVdVPMST--TAPSTKVDQPTRQKETSYYAPSTTSEPYGGYSTTTVee 310
                 45.34558999999999***********9999999988874.44444555555468777..67778888888777777777777777799999999854 PP

       Shisa 176 qpgmpa 181
                 ++++++
  EFC39905.1 311 TYKYEP 316
                 444443 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (356 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       816  (0.0455129); expected 358.6 (0.02)
Passed bias filter:                      430  (0.0239835); expected 358.6 (0.02)
Passed Vit filter:                        53  (0.0029561); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.65u 0.35s 00:00:01.00 Elapsed: 00:00:00.57
# Mc/sec: 1889.24
//
Query:       EFC39906.1  [L=624]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
      1e-28  100.5   0.7    1.3e-27   96.9   0.0    2.6  3  PseudoU_synth_2  RNA pseudouridylate synthase


Domain annotation for each model (and alignments):
>> PseudoU_synth_2  RNA pseudouridylate synthase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0      0.27   4.9e+03     114     148 ..     206     240 ..     174     244 .. 0.81
   2 ?    0.7   0.2     0.027   4.8e+02      71     119 ..     267     370 ..     256     406 .. 0.57
   3 !   96.9   0.0     7e-32   1.3e-27       2     160 .]     419     577 ..     418     577 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 0.27
  PseudoU_synth_2 114 eeldgkkavtylkvlksgsseksakvslvelelet 148
                      +e+++k+a t+ k+  +g ++++++ +l+e ++ t
       EFC39906.1 206 FEEQKKEAATRGKPFGKGNDKQQEDSTLLENTPTT 240
                      56778888888888888888888888888877776 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.027
  PseudoU_synth_2  71 feerkvrKkYlalvf..........................................................gapeeeegaikkkiskdtekq 106
                       ++ +++KkY+ l++                                                           +++e+ ++i+++i     k+
       EFC39906.1 267 VNSSSLKKKYVTLTVsqehddmrldkfltktlainfgliqkitrkkqlfkngiavkennervfkgdiikipkdFIDSEKRQEIDEHITG---KR 357
                      45667999999999866666666666666555555555555555555555555444444444444444444444444444444444444...55 PP

  PseudoU_synth_2 107 egarrkaeeldgk 119
                      e +++ ++e d+ 
       EFC39906.1 358 EQFNKAQRETDKI 370
                      5555544444444 PP

  == domain 3  score: 96.9 bits;  conditional E-value: 7e-32
  PseudoU_synth_2   2 lvvvnKPagvpvqpeakdgsekekettatssraeeekkelklvhRLDkatsGllllAksseaanklakafeerk..vrKkYlalvfgapeeeeg 93 
                      ++++nKP+g+ vq++  ++    + + ++     + + ++klvhRLD++t+G+l++A++++ a ++++ ++e +  ++K Y+a+++g p +++g
       EFC39906.1 419 IIALNKPYGICVQGGS-NQTFHIDALLDALTGLDGFNVRPKLVHRLDRDTTGVLIVARNRAGAIRMQQWLQESTvpLKKCYWAVTVGVPTPTTG 511
                      799*************.55555555555566666777789******************************9999788***************** PP

  PseudoU_synth_2  94 aikkkiskd...tekqegarrkaeeldgkkavtylkvlksgsseksakvslveleletGrkhQiRvhlaa 160
                      +ik  i+ +   +  +++  ++ +++  k +v+ +k+++++      k ++v+l ++tGrkhQ+Rvh+a+
       EFC39906.1 512 RIKMVIDIQkdaNGVEKVVPVDNKTDSSKISVSEYKTIDHM----TDKLAWVALYPVTGRKHQLRVHCAS 577
                      ****9999777767777777888888899999999999999....99*********************95 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (624 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1168  (0.0651459); expected 358.6 (0.02)
Passed bias filter:                      465  (0.0259356); expected 358.6 (0.02)
Passed Vit filter:                        38  (0.00211947); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.72u 0.33s 00:00:01.05 Elapsed: 00:00:00.55
# Mc/sec: 3440.40
//
Query:       EFC39907.1  [L=536]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-45  153.1  12.8    5.5e-13   48.9   0.0    8.9  9  PPR_2          PPR repeat family
    3.5e-37  124.0  16.7    0.00078   19.5   0.0   12.3 12  PPR            PPR repeat
    1.9e-29  102.1   1.9    2.9e-29  101.5   0.7    1.9  2  DYW_deaminase  DYW family of nucleic acid deaminases
    3.5e-25   87.9  10.3    9.5e-10   38.4   0.0    6.1  7  PPR_3          Pentatricopeptide repeat domain
    2.8e-14   53.0   0.0    2.9e-09   36.6   0.0    3.4  4  PPR_long       Pentacotripeptide-repeat region of PRORP
    1.3e-10   40.8  13.9       0.02   14.6   0.1    8.3  9  PPR_1          PPR repeat
     0.0009   18.4   2.2       0.28   10.2   0.0    3.1  3  AEP1           ATPase expression protein 1
     0.0053   16.5   0.9         14    5.4   0.0    5.1  7  RPN7           26S proteasome subunit RPN7
     0.0058   17.3   0.0         34    5.6   0.0    4.8  5  TPR_14         Tetratricopeptide repeat
      0.007   16.5   5.7         28    5.3   0.3    5.7  6  TPR_8          Tetratricopeptide repeat
  ------ inclusion threshold ------
      0.035   13.3   0.0      0.067   12.4   0.0    1.4  1  Aldo_ket_red   Aldo/keto reductase family
       0.16   11.6   0.0       0.34   10.6   0.0    1.4  1  CCDC85         CCDC85 family


Domain annotation for each model (and alignments):
>> PPR_2  PPR repeat family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.9   0.0     0.085   1.3e+02      10      33 ..       1      24 [.       1      27 [. 0.89
   2 !   38.5   0.1   6.3e-13   9.4e-10       2      49 ..      27      74 ..      26      75 .. 0.96
   3 ?    5.3   0.0     0.015        23       7      33 ..     102     128 ..     100     130 .. 0.89
   4 !   48.9   0.0   3.7e-16   5.5e-13       2      49 ..     131     178 ..     130     179 .. 0.96
   5 ?   -2.8   0.0         5   7.4e+03      12      30 ..     211     229 ..     209     231 .. 0.85
   6 !   37.2   0.0   1.6e-12   2.4e-09       3      49 ..     237     283 ..     235     299 .. 0.96
   7 ?    2.4   0.0      0.12   1.8e+02       8      26 ..     308     326 ..     301     328 .. 0.85
   8 !    8.1   0.0    0.0021       3.1       5      39 ..     334     369 ..     331     369 .. 0.90
   9 !    9.7   0.1   0.00064      0.95      12      35 ..     374     397 ..     370     398 .. 0.92

  Alignments for each domain:
  == domain 1  score: 2.9 bits;  conditional E-value: 0.085
       PPR_2 10 IsglckkgkveeAfklfneMkkrg 33
                +s + k g++e A++ f++ kk g
  EFC39907.1  1 MSFYTKCGHPELAMEEFEKLKKTG 24
                67799****************975 PP

  == domain 2  score: 38.5 bits;  conditional E-value: 6.3e-13
       PPR_2  2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49
                d+ ++N+l++++  +g+++ A++ f  M+ ++++Pn++ ++il+kg++
  EFC39907.1 27 DIGSWNCLLQAYISAGNISTAIQTFTTMQGNNISPNDIKFTILLKGCA 74
                6789******************************************97 PP

  == domain 3  score: 5.3 bits;  conditional E-value: 0.015
       PPR_2   7 NtlIsglckkgkveeAfklfneMkkrg 33 
                 +++++ + k gk+  A++l++e  + g
  EFC39907.1 102 TSIMNFYTKCGKPYVAVDLYDEFCEAG 128
                 689******************987766 PP

  == domain 4  score: 48.9 bits;  conditional E-value: 3.7e-16
       PPR_2   2 dvvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49 
                 +v t+++lI+++ + g+ +eAf +fneM k++++Pn +Ty +l++++ 
  EFC39907.1 131 NVGTCTALIQAFIEIGDANEAFTVFNEMLKQNFQPNIVTYLVLLQACS 178
                 899*******************************************86 PP

  == domain 5  score: -2.8 bits;  conditional E-value: 5
       PPR_2  12 glckkgkveeAfklfneMk 30 
                 ++ k g++e   ++f+e  
  EFC39907.1 211 YFSKIGELEASKQIFDELL 229
                 6789999999999**9976 PP

  == domain 6  score: 37.2 bits;  conditional E-value: 1.6e-12
       PPR_2   3 vvtyNtlIsglckkgkveeAfklfneMkkrglePnsyTysilikglc 49 
                 + t+N ++s ++++g+ +eAf ++    ++++eP+++T++il+++l 
  EFC39907.1 237 IETCNNILSVFAHHGEGSEAFNFYISFIEKNIEPTEKTFTILLNALS 283
                 569******************************************96 PP

  == domain 7  score: 2.4 bits;  conditional E-value: 0.12
       PPR_2   8 tlIsglckkgkveeAfklf 26 
                 ++ ++l++kg +e+A ++ 
  EFC39907.1 308 AMVDALARKGLLEQAESVI 326
                 899************9876 PP

  == domain 8  score: 8.1 bits;  conditional E-value: 0.0021
       PPR_2   5 tyNtlIsglckkgkveeAfklfneMkk.rglePnsy 39 
                  +Ntl+ g+ k +++e   ++f+ M +   leP++y
  EFC39907.1 334 LWNTLMCGCRKFNNLELGERVFKIMISiDELEPSAY 369
                 6************************99778888876 PP

  == domain 9  score: 9.7 bits;  conditional E-value: 0.00064
       PPR_2  12 glckkgkveeAfklfneMkkrgle 35 
                  +++ g ve+A k+ + Mk++g++
  EFC39907.1 374 IYMNYGLVEKANKIRELMKEKGIQ 397
                 6999******************97 PP

>> PPR  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.5   0.1      0.14   2.1e+02       8      28 ..       2      22 ..       1      24 [. 0.83
   2 !   15.7   0.0   8.4e-06     0.013       2      31 .]      30      59 ..      29      59 .. 0.95
   3 !    8.9   0.0    0.0013         2       3      25 ..      66      88 ..      65      91 .. 0.92
   4 !   11.0   0.0   0.00027       0.4       4      30 ..     102     128 ..     100     129 .. 0.93
   5 !   19.5   0.0   5.2e-07   0.00078       2      30 ..     134     162 ..     133     163 .. 0.94
   6 ?    2.3   0.0      0.16   2.4e+02       1      30 [.     168     197 ..     168     198 .. 0.78
   7 ?    1.8   0.1      0.24   3.5e+02      10      28 ..     212     230 ..     211     232 .. 0.90
   8 !   11.3   0.0   0.00023      0.34       2      31 .]     239     268 ..     238     268 .. 0.92
   9 !   14.8   0.0   1.7e-05     0.025       2      27 ..     274     299 ..     273     300 .. 0.93
  10 !    9.5   0.0   0.00082       1.2       5      24 ..     308     327 ..     307     328 .. 0.92
  11 !   15.3   0.2   1.1e-05     0.017       2      28 ..     334     360 ..     333     362 .. 0.94
  12 !    9.6   0.1   0.00079       1.2       9      31 .]     374     396 ..     370     396 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.5 bits;  conditional E-value: 0.14
         PPR  8 sgycknGkleeAlelfkeMke 28
                s y k+G +e A+e f+++k+
  EFC39907.1  2 SFYTKCGHPELAMEEFEKLKK 22
                669**********98888776 PP

  == domain 2  score: 15.7 bits;  conditional E-value: 8.4e-06
         PPR  2 tynslIsgycknGkleeAlelfkeMkekGi 31
                ++n+l+++y ++G+++ A++ f  M+ ++i
  EFC39907.1 30 SWNCLLQAYISAGNISTAIQTFTTMQGNNI 59
                8************************99876 PP

  == domain 3  score: 8.9 bits;  conditional E-value: 0.0013
         PPR  3 ynslIsgycknGkleeAlelfke 25
                +++l++g++ n+++ee +e+++ 
  EFC39907.1 66 FTILLKGCADNRLYEEGVEIHRM 88
                79*****************9876 PP

  == domain 4  score: 11.0 bits;  conditional E-value: 0.00027
         PPR   4 nslIsgycknGkleeAlelfkeMkekG 30 
                 +s+++ y k+Gk+  A++l++e  e G
  EFC39907.1 102 TSIMNFYTKCGKPYVAVDLYDEFCEAG 128
                 799*******************99988 PP

  == domain 5  score: 19.5 bits;  conditional E-value: 5.2e-07
         PPR   2 tynslIsgycknGkleeAlelfkeMkekG 30 
                 t+++lI+++   G+  eA+ +f+eM++ +
  EFC39907.1 134 TCTALIQAFIEIGDANEAFTVFNEMLKQN 162
                 89***********************9977 PP

  == domain 6  score: 2.3 bits;  conditional E-value: 0.16
         PPR   1 vtynslIsgycknGkleeAlelfkeMkekG 30 
                 vty +l++++++    +   +++k ++++G
  EFC39907.1 168 VTYLVLLQACSRFVSTDSGNRVIKHIQDNG 197
                 8**********9877777777777766666 PP

  == domain 7  score: 1.8 bits;  conditional E-value: 0.24
         PPR  10 ycknGkleeAlelfkeMke 28 
                 ++k G+le  +++f+e+++
  EFC39907.1 212 FSKIGELEASKQIFDELLK 230
                 6899************986 PP

  == domain 8  score: 11.3 bits;  conditional E-value: 0.00023
         PPR   2 tynslIsgycknGkleeAlelfkeMkekGi 31 
                 t+n ++s+++++G+ +eA+ ++   +ek+i
  EFC39907.1 239 TCNNILSVFAHHGEGSEAFNFYISFIEKNI 268
                 99********************99988875 PP

  == domain 9  score: 14.8 bits;  conditional E-value: 1.7e-05
         PPR   2 tynslIsgycknGkleeAlelfkeMk 27 
                 t+++l+++++++G++e + ++f  +k
  EFC39907.1 274 TFTILLNALSHSGMVEHVYSVFSSIK 299
                 9*********************8765 PP

  == domain 10  score: 9.5 bits;  conditional E-value: 0.00082
         PPR   5 slIsgycknGkleeAlelfk 24 
                 +++++++++G+le A+++++
  EFC39907.1 308 AMVDALARKGLLEQAESVID 327
                 7***************9976 PP

  == domain 11  score: 15.3 bits;  conditional E-value: 1.1e-05
         PPR   2 tynslIsgycknGkleeAlelfkeMke 28 
                  +n+l+ g+ k ++le  +++fk M++
  EFC39907.1 334 LWNTLMCGCRKFNNLELGERVFKIMIS 360
                 6************************86 PP

  == domain 12  score: 9.6 bits;  conditional E-value: 0.00079
         PPR   9 gycknGkleeAlelfkeMkekGi 31 
                  y   G++e+A ++ + MkekGi
  EFC39907.1 374 IYMNYGLVEKANKIRELMKEKGI 396
                 68889*****************7 PP

>> DYW_deaminase  DYW family of nucleic acid deaminases
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       1.8   2.7e+03      16      72 ..     212     266 ..     203     268 .. 0.68
   2 !  101.5   0.7   1.9e-32   2.9e-29       5     127 .]     404     526 ..     400     526 .. 0.91

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 1.8
  DYW_deaminase  16 asgdkahpeskeieekleelsqrllsigyapdlekalhdvkeeekekkplllsHsEK 72 
                    +s+ +    sk+i ++l +  + l      ++l++ +h+ +  e  +  +++s  EK
     EFC39907.1 212 FSKIGELEASKQIFDELLKYEKALSIETCNNILSVFAHHGEGSEAFN--FYISFIEK 266
                    55555566788898888877655555556688888888887777644..77776666 PP

  == domain 2  score: 101.5 bits;  conditional E-value: 1.9e-32
  DYW_deaminase   5 lvegkkkvvkfasgdkahpeskeieekleelsqrllsigyapdleka...lhdvkeeekekkplllsHsEKlalaygllktesgaqiriiknlrvC 97 
                      e ++ ++kf+sg  ++   +e+e+  +e++++++++gy+pd++ +    ++ k+e+  k  +ll+HsEK a+a ++   +++ +i  + nlrvC
     EFC39907.1 404 YHEENGITYKFVSGNDNFDRFNEVEQMRDEIFRKIIKAGYVPDVRWVpntEFKTKDERV-K--ALLRHSEKTAIAHAFVLNKDRKKILLTTNLRVC 496
                    5677899***********************************99865221678888866.6..8******************************** PP

  DYW_deaminase  98 eDChsafkliskilkaeivvrdaerfrhfk 127
                    +DChsa+ +isk++++ei+vrda+rf+hfk
     EFC39907.1 497 NDCHSATAFISKVMDCEIIVRDAKRFHHFK 526
                    *****************************7 PP

>> PPR_3  Pentatricopeptide repeat domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       1.7   2.6e+03      26      45 ..       5      24 ..       2      26 .. 0.83
   2 !   26.1   0.0   4.3e-09   6.5e-06      13      63 .]      26      76 ..      17      76 .. 0.94
   3 !   38.4   0.0   6.3e-13   9.5e-10      13      60 ..     130     177 ..     120     179 .. 0.95
   4 !   14.5   0.0   1.8e-05     0.028       2      60 ..     224     282 ..     223     284 .. 0.90
   5 ?   -2.0   0.0       2.6   3.9e+03      18      41 ..     335     358 ..     332     369 .. 0.86
   6 !    9.3   0.1   0.00076       1.1      23      51 ..     373     403 ..     362     406 .. 0.84
   7 ?   -0.3   0.1      0.76   1.1e+03      19      35 ..     472     488 ..     471     492 .. 0.87

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.7
       PPR_3 26 anagnkklalevlermkkkg 45
                 + g  +la+e +e++kk g
  EFC39907.1  5 TKCGHPELAMEEFEKLKKTG 24
                55677899*********976 PP

  == domain 2  score: 26.1 bits;  conditional E-value: 4.3e-09
       PPR_3 13 ldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgviggr 63
                +d+  ++ LL+ay+ agn   a +++  m+ + i+P+ + + ++l+ + ++
  EFC39907.1 26 VDIGSWNCLLQAYISAGNISTAIQTFTTMQGNNISPNDIKFTILLKGCADN 76
                688999****************************************99775 PP

  == domain 3  score: 38.4 bits;  conditional E-value: 6.3e-13
       PPR_3  13 ldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvi 60 
                 ++v t+t+L++a++  g+ + a+ v+++m k+  +P++vty ++l+++
  EFC39907.1 130 VNVGTCTALIQAFIEIGDANEAFTVFNEMLKQNFQPNIVTYLVLLQAC 177
                 799********************************************9 PP

  == domain 4  score: 14.5 bits;  conditional E-value: 1.8e-05
       PPR_3   2 ilremerkgikldvvtYthLLtayanagnkklalevlermkkkgikPtvvtyNailgvi 60 
                 i++e+ + +  l++ t++ +L+++a  g+   a++      +k i+Pt  t+ ++l++ 
  EFC39907.1 224 IFDELLKYEKALSIETCNNILSVFAHHGEGSEAFNFYISFIEKNIEPTEKTFTILLNAL 282
                 5666666666789*******************************************985 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 2.6
       PPR_3  18 YthLLtayanagnkklalevlerm 41 
                 +++L+ ++ +  n++l ++v++ m
  EFC39907.1 335 WNTLMCGCRKFNNLELGERVFKIM 358
                 688999999999999999999987 PP

  == domain 6  score: 9.3 bits;  conditional E-value: 0.00076
       PPR_3  23 tayanagnkklalevlermkkkgik..Ptvv 51 
                 + y+n g  + a+++ e mk+kgi+  P +v
  EFC39907.1 373 HIYMNYGLVEKANKIRELMKEKGIQvmPGIV 403
                 7899*******************96336665 PP

  == domain 7  score: -0.3 bits;  conditional E-value: 0.76
       PPR_3  19 thLLtayanagnkklal 35 
                 t++ +a+++++++k +l
  EFC39907.1 472 TAIAHAFVLNKDRKKIL 488
                 7889*********9886 PP

>> PPR_long  Pentacotripeptide-repeat region of PRORP
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.3   0.0   0.00011      0.16     127     174 ..      30      77 ..      11     110 .. 0.82
   2 !   17.4   0.0   1.4e-06    0.0021      90     155 ..     132     197 ..     117     198 .. 0.92
   3 !   36.6   0.0   1.9e-12   2.9e-09      25     187 ..     146     299 ..     139     310 .. 0.95
   4 ?   -2.2   0.0       1.4   2.1e+03     133     158 ..     373     398 ..     370     399 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00011
                 HHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHHHHHHHHTT CS
    PPR_long 127 syaPaLaayckagdadkaleveehlkasgveleEaelaaLLkvsakag 174
                 s++ +L+ay  ag++  a++    ++  ++++++  ++ LLk +a+  
  EFC39907.1  30 SWNCLLQAYISAGNISTAIQTFTTMQGNNISPNDIKFTILLKGCADNR 77 
                 78889*************************************999764 PP

  == domain 2  score: 17.4 bits;  conditional E-value: 1.4e-06
                 HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S---HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCT CS
    PPR_long  90 EatvtalarlaaakedgdlafelvkemekagvsPrLRsyaPaLaayckagdadkaleveehlkasg 155
                   t tal++     +d+++af++ +em k++ +P + +y  +L+a ++   +d +  v +h++  g
  EFC39907.1 132 VGTCTALIQAFIEIGDANEAFTVFNEMLKQNFQPNIVTYLVLLQACSRFVSTDSGNRVIKHIQDNG 197
                 5689**************************************************999999998766 PP

  == domain 3  score: 36.6 bits;  conditional E-value: 1.9e-12
                 T-HHHHHHHHHHHHHSSS---HHHHHHHHHHHHHC.HCSTTTHHHHHHHHHHHHHHHHHTT----HHHHHHHHHHHHHTT-HHHHHHHHHHHHHH-S-- CS
    PPR_long  25 kDaaaAlelydkavaegvrlaqyhynvllylcskaeaaseskknkalargfevfeamkakgvspnEatvtalarlaaakedgdlafelvkemekagvsP 123
                 +Da++A+ +++++ +++ + +  +y vll  cs+  +          ++g +v ++++ +g   nE + +++a   ++ ++ + + ++  e+ k++ + 
  EFC39907.1 146 GDANEAFTVFNEMLKQNFQPNIVTYLVLLQACSRFVS---------TDSGNRVIKHIQDNGLYNNEIIQSSIALYFSKIGELEASKQIFDELLKYEKAL 235
                 79******************************88742.........35789************************************************ PP

                 -HHHHHHHHHHHHHTT-HHHHHHHHHHHHHCT----HHHHHHHHHHHHHTT-HHHHHHHHHHHH CS
    PPR_long 124 rLRsyaPaLaayckagdadkaleveehlkasgveleEaelaaLLkvsakagredkvYelLhklr 187
                  + + + +L  + + g+   a++    +  +++e++E+ ++ LL++  + g  ++vY+++ +++
  EFC39907.1 236 SIETCNNILSVFAHHGEGSEAFNFYISFIEKNIEPTEKTFTILLNALSHSGMVEHVYSVFSSIK 299
                 **********************************************************998876 PP

  == domain 4  score: -2.2 bits;  conditional E-value: 1.4
                 HHHHHTT-HHHHHHHHHHHHHCT--- CS
    PPR_long 133 aayckagdadkaleveehlkasgvel 158
                 + y++ g ++ka ++ e +k +g+++
  EFC39907.1 373 HIYMNYGLVEKANKIRELMKEKGIQV 398
                 568899999***********999985 PP

>> PPR_1  PPR repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    6.4   0.0    0.0047         7       6      33 ..      27      54 ..      26      55 .. 0.91
   2 ?    4.4   0.0     0.021        31       2      20 ..      58      76 ..      57      87 .. 0.80
   3 ?   -0.3   0.0      0.59   8.8e+02      17      24 ..     124     131 ..     120     132 .. 0.87
   4 !   14.6   0.1   1.3e-05      0.02       6      33 ..     131     158 ..     127     159 .. 0.95
   5 ?    3.0   0.0     0.057        85       2      13 ..     162     173 ..     161     177 .. 0.78
   6 !    8.1   0.0    0.0014       2.1       1      24 [.     266     289 ..     266     297 .. 0.88
   7 ?    5.3   0.0     0.011        17      13      31 ..     309     327 ..     307     328 .. 0.90
   8 ?   -0.4   0.4      0.67     1e+03      10      33 ..     335     358 ..     332     359 .. 0.84
   9 ?   -2.8   0.1       3.6   5.4e+03      21      34 .]     379     392 ..     379     392 .. 0.86

  Alignments for each domain:
  == domain 1  score: 6.4 bits;  conditional E-value: 0.0047
                -HHHHHHHHHHHHHTS-HHHHHHHHHHH CS
       PPR_1  6 dvvTYNtLIdGlCkaGrvdeAfelfdeM 33
                d+ ++N+L+ ++  aG++  A++ f  M
  EFC39907.1 27 DIGSWNCLLQAYISAGNISTAIQTFTTM 54
                56689********************999 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.021
                S----HHHHHHHHHHHHHT CS
       PPR_1  2 GlkPdvvTYNtLIdGlCka 20
                +++P+ + +++L++G+  +
  EFC39907.1 58 NISPNDIKFTILLKGCADN 76
                799************7655 PP

  == domain 3  score: -0.3 bits;  conditional E-value: 0.59
                 HHHTS-HH CS
       PPR_1  17 lCkaGrvd 24 
                 +C aG+v+
  EFC39907.1 124 FCEAGLVN 131
                 9****996 PP

  == domain 4  score: 14.6 bits;  conditional E-value: 1.3e-05
                 -HHHHHHHHHHHHHTS-HHHHHHHHHHH CS
       PPR_1   6 dvvTYNtLIdGlCkaGrvdeAfelfdeM 33 
                 +v T + LI ++   G+ +eAf +f+eM
  EFC39907.1 131 NVGTCTALIQAFIEIGDANEAFTVFNEM 158
                 999************************* PP

  == domain 5  score: 3.0 bits;  conditional E-value: 0.057
                 S----HHHHHHH CS
       PPR_1   2 GlkPdvvTYNtL 13 
                 +++P++vTY  L
  EFC39907.1 162 NFQPNIVTYLVL 173
                 679******655 PP

  == domain 6  score: 8.1 bits;  conditional E-value: 0.0014
                 SS----HHHHHHHHHHHHHTS-HH CS
       PPR_1   1 kGlkPdvvTYNtLIdGlCkaGrvd 24 
                 k+++P+  T+++L+++l   G+v+
  EFC39907.1 266 KNIEPTEKTFTILLNALSHSGMVE 289
                 689**************9999987 PP

  == domain 7  score: 5.3 bits;  conditional E-value: 0.011
                 HHHHHHHTS-HHHHHHHHH CS
       PPR_1  13 LIdGlCkaGrvdeAfelfd 31 
                 ++d+l ++G+++ A+ + d
  EFC39907.1 309 MVDALARKGLLEQAESVID 327
                 89*************9877 PP

  == domain 8  score: -0.4 bits;  conditional E-value: 0.67
                 HHHHHHHHHHTS-HHHHHHHHHHH CS
       PPR_1  10 YNtLIdGlCkaGrvdeAfelfdeM 33 
                 +NtL  G+ k ++++  +++f+ M
  EFC39907.1 335 WNTLMCGCRKFNNLELGERVFKIM 358
                 8******99999999888888877 PP

  == domain 9  score: -2.8 bits;  conditional E-value: 3.6
                 S-HHHHHHHHHHHH CS
       PPR_1  21 GrvdeAfelfdeMe 34 
                 G+v++A ++ + M+
  EFC39907.1 379 GLVEKANKIRELMK 392
                 899***99998885 PP

>> AEP1  ATPase expression protein 1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.5   0.0      0.35   5.2e+02     235     265 ..      33      63 ..      29      69 .. 0.79
   2 !   10.2   0.0   0.00019      0.28     222     278 ..     123     177 ..      92     195 .. 0.75
   3 !    5.6   0.5    0.0048       7.2     230     277 ..     202     249 ..     192     296 .. 0.82

  Alignments for each domain:
  == domain 1  score: -0.5 bits;  conditional E-value: 0.35
        AEP1 235 ellefyikskdltesktllekLikkkiipse 265
                 +ll+ yi+++++ ++ ++++++  ++i p++
  EFC39907.1  33 CLLQAYISAGNISTAIQTFTTMQGNNISPND 63 
                 7888888888888888888888778877764 PP

  == domain 2  score: 10.2 bits;  conditional E-value: 0.00019
        AEP1 222 qncltkfspl.vlqellefyikskdltesktllekLikkkiipseesieaYLellekk 278
                 + c+  + ++ +  +l++ +i+++d +e+ t++++++k+++ p+   i +YL ll+  
  EFC39907.1 123 EFCEAGLVNVgTCTALIQAFIEIGDANEAFTVFNEMLKQNFQPN---IVTYLVLLQAC 177
                 66777776654778999************************997...66777776543 PP

  == domain 3  score: 5.6 bits;  conditional E-value: 0.0048
        AEP1 230 plvlqellefyikskdltesktllekLikkkiipseesieaYLellek 277
                 +++  ++  ++ k+++l+ sk+++++L+k +++ s e+ ++ L    +
  EFC39907.1 202 EIIQSSIALYFSKIGELEASKQIFDELLKYEKALSIETCNNILSVFAH 249
                 45566677999******************8888888888777766555 PP

>> RPN7  26S proteasome subunit RPN7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.4   0.0       1.1   1.7e+03      43      62 ..       1      20 [.       1      24 [. 0.88
   2 ?    0.0   0.0      0.41   6.1e+02      42      68 ..      34      60 ..      18      70 .. 0.83
   3 !    5.4   0.0     0.009        14      32      82 ..      94     145 ..      83     146 .. 0.83
   4 ?    4.8   0.0     0.013        20      41      72 ..     137     168 ..     133     175 .. 0.84
   5 ?    0.0   0.0       0.4   5.9e+02      41      68 ..     207     234 ..     191     249 .. 0.81
   6 ?   -1.2   0.0      0.96   1.4e+03      41      71 ..     242     272 ..     226     283 .. 0.76
   7 ?   -1.8   0.0       1.5   2.2e+03      42      65 ..     371     394 ..     367     400 .. 0.76

  Alignments for each domain:
  == domain 1  score: -1.4 bits;  conditional E-value: 1.1
                HHHHHHCT-HHHHHHHHHTC CS
        RPN7 43 aehYlkigdleeAlkaysri 62
                + +Y+k+g+ e A++ ++++
  EFC39907.1  1 MSFYTKCGHPELAMEEFEKL 20
                689************99985 PP

  == domain 2  score: 0.0 bits;  conditional E-value: 0.41
                HHHHHHHCT-HHHHHHHHHTCCCC--S CS
        RPN7 42 laehYlkigdleeAlkaysrireycts 68
                l + Y+++g+++ A++++  +    +s
  EFC39907.1 34 LLQAYISAGNISTAIQTFTTMQGNNIS 60
                6788*************9988766555 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.009
                 HHHHHHHHHHHHHHHHHCT-HHHHHHHHHT.CCCC--SHHHHHHHHHHHHHH CS
        RPN7  32 keeirrakldlaehYlkigdleeAlkaysr.ireyctslkhkidmllnlirv 82 
                 +  + ++   ++++Y+k+g+   A+ +y + +   +++ + +  ++ ++i++
  EFC39907.1  94 ENITTELATSIMNFYTKCGKPYVAVDLYDEfCEAGLVNVGTCTALIQAFIEI 145
                 55566778899*******************8888899999999888888887 PP

  == domain 4  score: 4.8 bits;  conditional E-value: 0.013
                 HHHHHHHHCT-HHHHHHHHHTCCCC--SHHHH CS
        RPN7  41 dlaehYlkigdleeAlkaysrireyctslkhk 72 
                 +l + +++igd +eA+  +++++++  +++ +
  EFC39907.1 137 ALIQAFIEIGDANEAFTVFNEMLKQNFQPNIV 168
                 78899*****************9988777655 PP

  == domain 5  score: 0.0 bits;  conditional E-value: 0.4
                 HHHHHHHHCT-HHHHHHHHHTCCCC--S CS
        RPN7  41 dlaehYlkigdleeAlkaysrireycts 68 
                  +a ++ kig+le + + + ++++y   
  EFC39907.1 207 SIALYFSKIGELEASKQIFDELLKYEKA 234
                 67889**********9999999888665 PP

  == domain 6  score: -1.2 bits;  conditional E-value: 0.96
                 HHHHHHHHCT-HHHHHHHHHTCCCC--SHHH CS
        RPN7  41 dlaehYlkigdleeAlkaysrireyctslkh 71 
                 ++   ++ +g+ +eA++ y   +e+ + +  
  EFC39907.1 242 NILSVFAHHGEGSEAFNFYISFIEKNIEPTE 272
                 5667899999999****99997777666544 PP

  == domain 7  score: -1.8 bits;  conditional E-value: 1.5
                 HHHHHHHCT-HHHHHHHHHTCCCC CS
        RPN7  42 laehYlkigdleeAlkaysrirey 65 
                 l + Y++ g +e+A k  + + e+
  EFC39907.1 371 LSHIYMNYGLVEKANKIRELMKEK 394
                 678899999999998877666665 PP

>> TPR_14  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   0.0       4.3   6.5e+03      10      27 ..       3      20 ..       1      24 [. 0.85
   2 ?    4.6   0.0     0.049        73       4      25 ..      31      52 ..      28      70 .. 0.86
   3 ?   -1.9   0.0       5.8   8.6e+03       9      29 ..     106     126 ..     103     128 .. 0.83
   4 ?    5.6   0.0     0.023        34       6      33 ..     137     166 ..     136     176 .. 0.78
   5 ?   -1.5   0.1       4.3   6.4e+03       7      22 ..     309     324 ..     308     327 .. 0.81

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 4.3
      TPR_14 10 allalGdpdeAiallrra 27
                ++   G p+ A++ ++++
  EFC39907.1  3 FYTKCGHPELAMEEFEKL 20
                78899********99975 PP

  == domain 2  score: 4.6 bits;  conditional E-value: 0.049
      TPR_14  4 llalaeallalGdpdeAiallr 25
                + +l++a+  +G+  +Ai+ + 
  EFC39907.1 31 WNCLLQAYISAGNISTAIQTFT 52
                789***************9885 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 5.8
      TPR_14   9 eallalGdpdeAiallrrala 29 
                  ++   G+p  A++l+++ ++
  EFC39907.1 106 NFYTKCGKPYVAVDLYDEFCE 126
                 57889999********98765 PP

  == domain 4  score: 5.6 bits;  conditional E-value: 0.023
      TPR_14   6 alaeallalGdpdeAiallrralala..Pd 33 
                 al +a+ + Gd  eA ++++++l+++  P+
  EFC39907.1 137 ALIQAFIEIGDANEAFTVFNEMLKQNfqPN 166
                 68999*******************853365 PP

  == domain 5  score: -1.5 bits;  conditional E-value: 4.3
      TPR_14   7 laeallalGdpdeAia 22 
                 +++al++ G +++A+ 
  EFC39907.1 309 MVDALARKGLLEQAES 324
                 7889999999999986 PP

>> TPR_8  Tetratricopeptide repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.0      0.07     1e+02      10      27 ..       3      20 ..       2      22 .. 0.89
   2 ?    2.3   0.0      0.17   2.5e+02       3      24 ..      30      51 ..      28      53 .. 0.86
   3 ?    0.3   0.0      0.72   1.1e+03      10      29 ..     141     160 ..     138     164 .. 0.84
   4 ?    5.3   0.3     0.019        28       7      32 ..     208     233 ..     206     237 .. 0.88
   5 ?   -2.7   0.0       6.8     1e+04       9      22 ..     311     324 ..     307     326 .. 0.76
   6 ?    1.4   0.1      0.33   4.9e+02       3      20 ..     367     384 ..     365     387 .. 0.82

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.07
                HHHHTT-HHHHHHHHHHH CS
       TPR_8 10 iylklgdyeeAkeyyeka 27
                 y k g  e A+e +ek 
  EFC39907.1  3 FYTKCGHPELAMEEFEKL 20
                6999************96 PP

  == domain 2  score: 2.3 bits;  conditional E-value: 0.17
                HHHHHHHHHHHTT-HHHHHHHH CS
       TPR_8  3 ayynlgsiylklgdyeeAkeyy 24
                +++ l ++y++ g++  A++++
  EFC39907.1 30 SWNCLLQAYISAGNISTAIQTF 51
                5666899************998 PP

  == domain 3  score: 0.3 bits;  conditional E-value: 0.72
                 HHHHTT-HHHHHHHHHHHHH CS
       TPR_8  10 iylklgdyeeAkeyyekale 29 
                 + ++ gd +eA  ++++ l+
  EFC39907.1 141 AFIEIGDANEAFTVFNEMLK 160
                 67899********9998766 PP

  == domain 4  score: 5.3 bits;  conditional E-value: 0.019
                 HHHHHHHTT-HHHHHHHHHHHHHHHH CS
       TPR_8   7 lgsiylklgdyeeAkeyyekaleldp 32 
                 +++  +k g++e++k+ + + l++++
  EFC39907.1 208 IALYFSKIGELEASKQIFDELLKYEK 233
                 5667799***************9876 PP

  == domain 5  score: -2.7 bits;  conditional E-value: 6.8
                 HHHHHTT-HHHHHH CS
       TPR_8   9 siylklgdyeeAke 22 
                 +++  +g +e+A++
  EFC39907.1 311 DALARKGLLEQAES 324
                 67778899999986 PP

  == domain 6  score: 1.4 bits;  conditional E-value: 0.33
                 HHHHHHHHHHHTT-HHHH CS
       TPR_8   3 ayynlgsiylklgdyeeA 20 
                 + y+l++iy++ g  e+A
  EFC39907.1 367 SAYLLSHIYMNYGLVEKA 384
                 5699******98887777 PP

>> Aldo_ket_red  Aldo/keto reductase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   0.0   4.5e-05     0.067     159     260 ..     373     488 ..     357     493 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 4.5e-05
                   EEE-B-BTT-HHHHTTHHHHHHHTT-EEEEBSTTGG..GTTGTTTSS---SSSCCC-------................TS-HHHHHHHHHHHHHHH CS
  Aldo_ket_red 159 avqveynllreleeegllelckkkgvpliaysplgg..Glltgkyqseedkedkeprkdlkrd................ertsknldaaeelselak 237
                    ++++y l+  +++++++el+k+kg+++++  + +   G+  + +  +++++++++ ++++++                  + ++ +++e++++l +
    EFC39907.1 373 HIYMNYGLV--EKANKIRELMKEKGIQVMPGIVYHEenGITYKFVSGNDNFDRFNEVEQMRDEifrkiikagyvpdvrwVPNTEFKTKDERVKALLR 467
                   5789*****..******************7766665558888888889999999999999999*************977667778899999999999 PP

                   HTT--HHHHHHHHHTTSTT-SEE CS
  Aldo_ket_red 238 ehgvslaqlalryalsqpavgiv 260
                   +  ++  ++a++++l+++++ i+
    EFC39907.1 468 HSEKT--AIAHAFVLNKDRKKIL 488
                   87765..6899999999888776 PP

>> CCDC85  CCDC85 family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.6   0.0   0.00023      0.34      86     124 ..     185     223 ..     177     243 .. 0.82

  Alignments for each domain:
  == domain 1  score: 10.6 bits;  conditional E-value: 0.00023
      CCDC85  86 kgkkvareWqrlGryaakvlrkevalylqklkeLearqe 124
                  g +v +  q  G y  ++++  +aly  k+ eLea ++
  EFC39907.1 185 SGNRVIKHIQDNGLYNNEIIQSSIALYFSKIGELEASKQ 223
                 689999*****************************8653 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (536 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       867  (0.0483574); expected 358.6 (0.02)
Passed bias filter:                      590  (0.0329076); expected 358.6 (0.02)
Passed Vit filter:                        54  (0.00301188); expected 17.9 (0.001)
Passed Fwd filter:                        12  (0.000669307); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.73u 0.33s 00:00:01.06 Elapsed: 00:00:00.53
# Mc/sec: 3028.59
//
Query:       EFC39908.1  [L=818]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.8e-29  102.4   0.0    1.2e-28  100.3   0.0    2.0  2  ABC_tran       ABC transporter
    2.1e-17   63.2  10.4    2.1e-17   63.2  10.4    1.9  2  ABC2_membrane  ABC-2 type transporter
    0.00012   22.0   0.9       0.04   13.7   0.2    2.4  2  AAA_21         AAA domain, putative AbiEii toxin, Type IV TA 
    0.00052   19.9   0.1     0.0011   18.9   0.1    1.5  1  RsgA_GTPase    RsgA GTPase
    0.00097   18.8   0.4     0.0027   17.4   0.4    1.8  1  AAA_29         P-loop containing region of AAA domain
      0.001   18.6   0.1     0.0072   15.8   0.1    2.1  1  SMC_N          RecF/RecN/SMC N terminal domain
     0.0055   16.7   1.1      0.016   15.2   1.1    1.8  1  DUF4446        Protein of unknown function (DUF4446)
  ------ inclusion threshold ------
      0.014   15.9   0.2      0.014   15.9   0.2    2.8  3  AAA_23         AAA domain
      0.072   13.4  17.3       0.29   11.5   3.7    4.5  4  EGF            EGF-like domain
       0.14   12.1   5.4        2.1    8.3   0.1    3.2  2  cEGF           Complement Clr-like EGF-like
       0.18   12.2   0.0       0.33   11.3   0.0    1.4  1  AAA_16         AAA ATPase domain
        5.4    7.8  28.1      0.045   14.4   4.5    4.5  5  hEGF           Human growth factor-like EGF


Domain annotation for each model (and alignments):
>> ABC_tran  ABC transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  100.3   0.0   8.1e-32   1.2e-28       1     137 []     391     544 ..     391     544 .. 0.96
   2 ?   -1.3   0.0       1.9   2.8e+03      87     111 ..     627     651 ..     575     698 .. 0.71

  Alignments for each domain:
  == domain 1  score: 100.3 bits;  conditional E-value: 8.1e-32
                 EEEEEEEEETTSEEEEEESTTSSHHHHHHHHTTSS--..SEEEEEETTCEGGGB-HHHCCHCEEEE-SS.--S-TTSBHHHH................H CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxx................x RF
    ABC_tran   1 lknvslklkegekvaivGenGaGKStLlkllagllkp..teGeilldgkdlkeqeleslrkeigvlpqe.pqlfpeltvren................e 80 
                 l+ +s ++k+g+++ai+G++GaGK++Ll ++ag +k     Ge+l+++k++++   +++++  g+++q  ++l  +ltv e+                e
  EFC39908.1 391 LHGLSHTFKPGTVTAIMGPSGAGKTSLLDIIAGRSKSgdVFGELLVNNKPIDY---NQYKRVAGYVSQSdDHLMGTLTVFESimfsaelrlpdtvpytE 486
                 678999****************************9986677899*******99...999999******999**************************** PP

                 HHTCHHHHHHHSTTGGTTCBGESTTS.GGS-HHHHHHHHHHHHHHHTSSEEEEESTTT CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  81 sdeeiekalsklglkelkdtvvkssp.ssLSgGqkqrvalarallkkpkllllDEpta 137
                 +++++e ++++lg+++++d+++++ + + +SgG+k+rv++a+ l+ +p++l+lDEpt+
  EFC39908.1 487 KKRRVESVMEELGISHIRDRKIGDAMtRGISGGEKRRVSIACELVIAPQILFLDEPTS 544
                 **********************99999*****************************96 PP

  == domain 2  score: -1.3 bits;  conditional E-value: 1.9
                 HHHHHSTTGGTTCBGESTTSGGS-H CS
                 xxxxxxxxxxxxxxxxxxxxxxxxx RF
    ABC_tran  87 kalsklglkelkdtvvksspssLSg 111
                 +++s+++ +e++ t ++++ +sLS+
  EFC39908.1 627 DVMSEMSENETQGTSINQNNQSLSY 651
                 4455555555555555555555554 PP

>> ABC2_membrane  ABC-2 type transporter
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.0   0.6      0.67     1e+03     102     119 ..     292     309 ..     284     317 .. 0.49
   2 !   63.2  10.4   1.4e-20   2.1e-17       1     122 [.     693     814 ..     693     818 .] 0.92

  Alignments for each domain:
  == domain 1  score: -1.0 bits;  conditional E-value: 0.67
  ABC2_membrane 102 lvelpvsllqaliflliv 119
                    ++++++ ++++++++ i+
     EFC39908.1 292 VGSVIFVAIMIVLIFSII 309
                    334333344444443333 PP

  == domain 2  score: 63.2 bits;  conditional E-value: 1.4e-20
  ABC2_membrane   1 tqikallkreflqrwrdpslgllwrliqplllalvfgtvfgnlgnsedgl.nrpgllffsvlflafsaltsvapvferergvlerelvsplyslsa 95 
                    tq+++l kr+f++++r+ +l   +  ++ ++++l++g +++++ n+ ++  nr+g +ff++  l f+a++s+  +f++er +++re+++++y   +
     EFC39908.1 693 TQLYILSKRSFRNFYRNFYLM-PAHYLSAIIMGLLLGAIYFQQSNNIQACqNRMGSIFFMCALLNFAAMSSL-ELFITERTIYVRERANGYYLSIS 786
                    699***************888.89*****************999655555499************8888888.*********************** PP

  ABC2_membrane  96 yvlakvlve.lpvsllqalifllivyfl 122
                    y+++k++++ +p+ ++  +i+  i+y+ 
     EFC39908.1 787 YFFSKTFFDlIPLRVIPPIIMGSIAYVS 814
                    **************************86 PP

>> AAA_21  AAA domain, putative AbiEii toxin, Type IV TA system
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.7   0.2   2.7e-05      0.04       1      21 [.     403     423 ..     403     448 .. 0.78
   2 !    6.5   0.1    0.0043       6.4     238     299 ..     517     576 ..     428     577 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.7 bits;  conditional E-value: 2.7e-05
      AAA_21   1 lnvliGpNgsGKSnLLdaldl 21 
                 ++++ Gp g+GK++LLd++ +
  EFC39908.1 403 VTAIMGPSGAGKTSLLDIIAG 423
                 699****************54 PP

  == domain 2  score: 6.5 bits;  conditional E-value: 0.0043
      AAA_21 238 SdGtkrllalltallralkkgsllliDEpEngLHP.kllrrllellkelsrngaQviltTHSp 299
                 S G kr   ++  l  a+    +l++DEp +gL+  ++++++ ++ +++++++  ++++ H+p
  EFC39908.1 517 SGGEKRRVSIACELVIAP---QILFLDEPTSGLDSyHAVSTIKTICDLATKHNRTIVFSIHQP 576
                 555555555555555555...9***********987777777777777777888888876665 PP

>> RsgA_GTPase  RsgA GTPase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.9   0.1   7.5e-07    0.0011      57     123 ..     360     425 ..     326     473 .. 0.73

  Alignments for each domain:
  == domain 1  score: 18.9 bits;  conditional E-value: 7.5e-07
                  GG--HHHHHHHHHHHHHHTTSEEEE--TTTHTTHHHHHHHCTT.SEEEEECSTTSSHHHHHHHHCTT- CS
  RsgA_GTPase  57 Dlleeeeeleelkeelealgyevllvsaktkegleelkellkd.ktsvlvGqSGvGKStLinallpel 123
                    ++ee+ + + ++e e+ + ++ l s+++ + l+ l++ +k   +++++G+SG+GK++L++ ++++ 
   EFC39908.1 360 SGVNEED-IAKEEKE-EERERALHLKSKNRITLLHGLSHTFKPgTVTAIMGPSGAGKTSLLDIIAGRS 425
                  4444444.2222222.222233444445555778889999998899****************999874 PP

>> AAA_29  P-loop containing region of AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.4   1.8e-06    0.0027      13      42 ..     392     421 ..     386     445 .. 0.89

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 1.8e-06
      AAA_29  13 dghtieidlkgatlltGpsGsGKSTllDAi 42 
                 +g ++++++  +t ++GpsG+GK++llD i
  EFC39908.1 392 HGLSHTFKPGTVTAIMGPSGAGKTSLLDII 421
                 56677888888*****************55 PP

>> SMC_N  RecF/RecN/SMC N terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   0.1   4.8e-06    0.0072      25     206 ..     402     582 ..     392     595 .. 0.71

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 4.8e-06
                 SEEEEEESTTSSHHHHHHHHHHHCTT.TTTTTTCHCCCCCC--BTTCSSTTEEEEEEEEEETTEESSSSSSC.EEEEEEEETTSEEEEEETTEEE-HHH CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N  25 sftaivGpNGSGKsnlldAilFvLGersakklrseklsdlihkskekasvkkaeveitfdnedkklkiekee.vsisrrvkrkgeseykingkevtkke 122
                  +tai+Gp G+GK++lld i    G +++     + + +l+ ++k  +  +  +v+ +++++d++l  + +   si+ +++     ++   +k+ + + 
  EFC39908.1 402 TVTAIMGPSGAGKTSLLDII---AGRSKS----GDVFGELLVNNKPIDYNQYKRVAGYVSQSDDHLMGTLTVfESIMFSAELRLPDTVPYTEKKRRVES 493
                 489***************99...675444....777888888878888899999999999999884333322124444444444456666677777777 PP

                 HHHHHHCTT-STT........CS-HHHHHHHHHHHHHHHHCCS--SEEEECTTTTTS-HHHHHHHHHHHH.HHCTTSEEEEE-SSHHHCCC-S CS
                 xxxxxxxxxxxxx........xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxx RF
       SMC_N 123 vsellesagiske........lLSgGektLvalaLlfAiqkvkpaplyllDeidaaLDeknvkkvaellk.eksknaQfivislreemlekad 206
                 v+e l  ++i            +SgGek  v++a  + i    p+ + +lDe  + LD  +     + +   ++k+   iv s+++   +  +
  EFC39908.1 494 VMEELGISHIRDRkigdamtrGISGGEKRRVSIACELVIA---PQ-ILFLDEPTSGLDSYHAVSTIKTICdLATKHNRTIVFSIHQPRSNIFQ 582
                 77777777776668999999999*****999988766553...44.6679********98866655555526777899999999775544443 PP

>> DUF4446  Protein of unknown function (DUF4446)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.2   1.1     1e-05     0.016       4      74 ..     295     373 ..     292     380 .. 0.79

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 1e-05
     DUF4446   4 lvlavlvvillillivllvklkklkkkykklmk........gkdgksleellkekleeveelkeeseelekeieeleek 74 
                 +++++++++l++ +i+  ++++k+k++y+ +mk        + + ++l  +++++ +++++l+e s  +e++i++ e++
  EFC39908.1 295 VIFVAIMIVLIFSIIYSKLQTRKVKHEYEDMMKtgnnefgaKLEIRNLTYIIRTTAKKINSLQEVSGVNEEDIAKEEKE 373
                 5678889999999999****************96555554233567888899999999999999888888888776665 PP

>> AAA_23  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.5   3.6         2   2.9e+03      96     153 ..     321     377 ..     299     393 .. 0.47
   2 ?   15.9   0.2   9.6e-06     0.014      17      39 ..     398     421 ..     388     423 .. 0.85
   3 ?   -2.0   0.4       2.9   4.4e+03      90     114 ..     649     675 ..     619     707 .. 0.44

  Alignments for each domain:
  == domain 1  score: -1.5 bits;  conditional E-value: 2
      AAA_23  96 lskkkgkttkkaklelleideleqfisellgskkiilnlilflgqerfeefelkdkke 153
                 ++++++kt +++ + +lei++l+ +i++   +k ++l+ ++   +e+ +++e++++ e
  EFC39908.1 321 EYEDMMKTGNNEFGAKLEIRNLTYIIRTT-AKKINSLQEVSGVNEEDIAKEEKEEERE 377
                 33444444444444444444444444432.1122223333333333332222222222 PP

  == domain 2  score: 15.9 bits;  conditional E-value: 9.6e-06
      AAA_23  17 Fsk.gltlItGpNGaGKTTildAi 39 
                 F++  +t+I Gp GaGKT++ld i
  EFC39908.1 398 FKPgTVTAIMGPSGAGKTSLLDII 421
                 555259****************88 PP

  == domain 3  score: -2.0 bits;  conditional E-value: 2.9
      AAA_23  90 iererelskkkg..kttkkaklellei 114
                 ++++++  k++g  ++ ++++  l+++
  EFC39908.1 649 LSYQQPIFKQSGygSENQESQNLLVKT 675
                 222222222222002222222222222 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   3.7   0.00019      0.29       1      29 [.      18      44 ..      16      47 .. 0.77
   2 ?    6.7   0.3    0.0061       9.1      18      30 ..      88     100 ..      81     102 .. 0.84
   3 ?   -1.6   0.2       2.4   3.6e+03       6      16 ..     106     116 ..     101     124 .. 0.64
   4 ?    2.2   0.0      0.16   2.4e+02       5      15 ..     261     271 ..     258     276 .. 0.87

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 0.00019
                GCSTT.STTT-EEEEETTTEEEEEECTTEE CS
         EGF  1 Cspnp.CsngGtCvdtgrggytCiCpeGyt 29
                C+++  C+n G C +   +  tC C +G++
  EFC39908.1 18 CDSDArCMNAGYC-S--TDNTTCVCLPGFK 44
                7774448888888.4..569********97 PP

  == domain 2  score: 6.7 bits;  conditional E-value: 0.0061
                 TEEEEEECTTEES CS
         EGF  18 ggytCiCpeGytG 30 
                  ++ C C++G+ G
  EFC39908.1  88 KSPVCSCQPGWEG 100
                 6789*******99 PP

  == domain 3  score: -1.6 bits;  conditional E-value: 2.4
                 STTT-EEEEET CS
         EGF   6 CsngGtCvdtg 16 
                 Csn+  C +  
  EFC39908.1 106 CSNDYVCQQRL 116
                 88887776655 PP

  == domain 4  score: 2.2 bits;  conditional E-value: 0.16
                 TSTTT-EEEEE CS
         EGF   5 pCsngGtCvdt 15 
                 +C++ ++Cvd+
  EFC39908.1 261 TCDHAAECVDV 271
                 6*******996 PP

>> cEGF  Complement Clr-like EGF-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.3   0.1    0.0014       2.1       3      13 ..      36      45 ..      34      58 .. 0.74
   2 ?    3.6   1.6     0.042        63       2      11 ..      90      99 ..      89     109 .. 0.81

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0014
                EEE-STTEEE. CS
        cEGF  3 rCsCppGYklt 13
                +C C pG+k +
  EFC39908.1 36 TCVCLPGFK-N 45
                8********.4 PP

  == domain 2  score: 3.6 bits;  conditional E-value: 0.042
                EEEE-STTEE CS
        cEGF  2 YrCsCppGYk 11
                  CsC pG +
  EFC39908.1 90 PVCSCQPGWE 99
                57******87 PP

>> AAA_16  AAA ATPase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   0.00022      0.33      20      45 ..     398     422 ..     384     464 .. 0.74

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 0.00022
      AAA_16  20 rsgrpelvllsGesGvGKsslvrell 45 
                  +++  ++ + G+sG GK+sl++ ++
  EFC39908.1 398 FKPG-TVTAIMGPSGAGKTSLLDIIA 422
                 3333.6899*************8776 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.4   4.5     3e-05     0.045       1      22 []      24      43 ..      24      43 .. 0.91
   2 ?   10.5   0.2    0.0005      0.74      10      22 .]      86      98 ..      82      98 .. 0.83
   3 ?   -1.7   0.6       3.6   5.4e+03       7      17 ..     106     113 ..     106     124 .. 0.65
   4 ?   -2.8   0.5       8.2   1.2e+04       1       8 [.     240     248 ..     240     253 .. 0.78
   5 ?   -2.7   0.1       7.4   1.1e+04       7      16 ..     741     752 ..     740     752 .. 0.73

  Alignments for each domain:
  == domain 1  score: 14.4 bits;  conditional E-value: 3e-05
                --TT-EES..-SS.-EE--TTX CS
        hEGF  1 CnngGtCidgvggykCiCpPGy 22
                C n G C    ++++C+C+PG+
  EFC39908.1 24 CMNAGYCS--TDNTTCVCLPGF 43
                9*******..6667*******9 PP

  == domain 2  score: 10.5 bits;  conditional E-value: 0.0005
                .-SS.-EE--TTX CS
        hEGF 10 gvggykCiCpPGy 22
                   +++C C PG+
  EFC39908.1 86 DDKSPVCSCQPGW 98
                55689******** PP

  == domain 3  score: -1.7 bits;  conditional E-value: 3.6
                 ES..-SS.-EE CS
        hEGF   7 CidgvggykCi 17 
                 C    + y+C+
  EFC39908.1 106 CS---NDYVCQ 113
                 44...556664 PP

  == domain 4  score: -2.8 bits;  conditional E-value: 8.2
                 --TT-.EES CS
        hEGF   1 CnngG.tCi 8  
                 Cnn + +C 
  EFC39908.1 240 CNNETkSCS 248
                 999987886 PP

  == domain 5  score: -2.7 bits;  conditional E-value: 7.4
                 ES..-SS...-E CS
        hEGF   7 Cidgvgg..ykC 16 
                 C+++ g+  ++C
  EFC39908.1 741 CQNRMGSifFMC 752
                 777777777888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (818 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1371  (0.0764683); expected 358.6 (0.02)
Passed bias filter:                      710  (0.0396006); expected 358.6 (0.02)
Passed Vit filter:                        94  (0.0052429); expected 17.9 (0.001)
Passed Fwd filter:                        15  (0.000836633); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              12  [number of targets reported over threshold]
# CPU time: 0.86u 0.34s 00:00:01.20 Elapsed: 00:00:00.54
# Mc/sec: 4540.91
//
Query:       EFC39909.1  [L=466]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.6e-35  121.5   1.1    1.1e-11   45.1   0.0    7.2  7  RCC1      Regulator of chromosome condensation (RCC1) repeat
    8.3e-21   73.3  12.8    0.00034   20.3   0.1    7.1  7  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.0     2e-05      0.18       4      42 ..      30      78 ..      29      81 .. 0.70
   2 ?    1.7   0.0     0.045     4e+02      24      50 .]     123     152 ..      99     152 .. 0.68
   3 !   13.6   0.0   8.7e-06     0.078       1      50 []     155     204 ..     155     204 .. 0.92
   4 !   22.7   0.0   1.3e-08   0.00011       4      49 ..     210     254 ..     208     254 .. 0.88
   5 !   45.1   0.0   1.2e-15   1.1e-11       1      50 []     258     307 ..     258     307 .. 0.98
   6 !    4.3   0.0    0.0072        64      22      45 ..     336     359 ..     324     363 .. 0.81
   7 !   12.4   0.1   2.1e-05      0.19       1      20 [.     367     386 ..     367     398 .. 0.81

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 2e-05
                EEEEE--GGGTTSSSS-..--EEEEEE-......GGGTTS..-EEEEEE CS
        RCC1  4 VysWGrndyGqLGlgtt..esvlvPtkv......eglsgn..rvvkvac 42
                V+s Grn+ +qLG  ++  +s  +P+ +      +gl++   +v +v c
  EFC39909.1 30 VLSMGRNHCHQLGFSNQnaQSIYYPKYLnptlrmNGLEEGyeKVEHVYC 78
                89************99954555777555322222555555888888887 PP

  == domain 2  score: 1.7 bits;  conditional E-value: 0.045
                 EEEEE-GGGTTS...-EEEEEEETTEEEEE CS
        RCC1  24 lvPtkveglsgn...rvvkvacGddhtval 50 
                 + Ptk+++  ++    + k++ G+ h ++l
  EFC39909.1 123 TAPTKLPFVWKDsedFIDKITLGSEHLFVL 152
                 4499998877667845555*******9986 PP

  == domain 3  score: 13.6 bits;  conditional E-value: 8.7e-06
                 TTEEEEEE--GGGTTSSSS-...--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgtt...esvlvPtkveglsgnrvvkvacGddhtval 50 
                 +G++y+ G+n    LGl+++   ++    ++++  +g+ + k++cG + t+++
  EFC39909.1 155 KGKIYGLGSNKCFELGLPKErmyDQL---SRITINNGEVIRKIVCGESCTFFI 204
                 599**************999898777...99*9999999999*********97 PP

  == domain 4  score: 22.7 bits;  conditional E-value: 1.3e-08
                 EEEEE--GGGTTSSSS---E.EEEEE-GGGTTS-EEEEEEETTEEEE CS
        RCC1   4 VysWGrndyGqLGlgttesv.lvPtkveglsgnrvvkvacGddhtva 49 
                 V++ G n+yG LG+ + ++v +vP  +++ +  ++ ++ cG++ht++
  EFC39909.1 210 VFASGLNNYGKLGTYNAKDViTVPLMLPTMN--NIEDIYCGSSHTIF 254
                 9*************888777699*8888877..************85 PP

  == domain 5  score: 45.1 bits;  conditional E-value: 1.2e-15
                 TTEEEEEE--GGGTTSSSS---EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   1 dGrVysWGrndyGqLGlgttesvlvPtkveglsgnrvvkvacGddhtval 50 
                 dG++y++G+n  GqLGlg+te +  P+++e+++++++v+v cG ++t++l
  EFC39909.1 258 DGSLYGCGNNLLGQLGLGSTELHAGPVLIEPFTDQEIVSVKCGENFTMFL 307
                 9**********************99***********************96 PP

  == domain 6  score: 4.3 bits;  conditional E-value: 0.0072
                 -EEEEEE-GGGTTS..-EEEEEEETT CS
        RCC1  22 svlvPtkveglsgn..rvvkvacGdd 45 
                 ++  P k++ ++++   ++++ cG+d
  EFC39909.1 336 CR--PIKITYFDSKnvLITSIECGSD 359
                 33..9*******999999******98 PP

  == domain 7  score: 12.4 bits;  conditional E-value: 2.1e-05
                 TTEEEEEE--GGGTTSSSS- CS
        RCC1   1 dGrVysWGrndyGqLGlgtt 20 
                 +G+Vy+ G n+yG LG+  +
  EFC39909.1 367 NGDVYGAGANSYGALGHIEH 386
                 69**************9544 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.9   0.0     0.023   2.1e+02      20      30 .]      30      40 ..      13      40 .. 0.78
   2 ?    0.4   0.1     0.069   6.2e+02      11      25 ..      87     102 ..      74     105 .. 0.81
   3 !   12.7   0.0   9.7e-06     0.087       4      28 ..     142     166 ..     139     167 .. 0.90
   4 !   10.1   0.0   6.2e-05      0.56       1      29 [.     191     219 ..     191     220 .. 0.95
   5 !   20.3   0.1   3.8e-08   0.00034       1      30 []     242     271 ..     242     271 .. 0.96
   6 !   17.0   0.0   4.1e-07    0.0037       1      25 [.     294     318 ..     294     322 .. 0.93
   7 !   12.1   1.0   1.5e-05      0.13       1      29 [.     351     379 ..     351     380 .. 0.96

  Alignments for each domain:
  == domain 1  score: 1.9 bits;  conditional E-value: 0.023
      RCC1_2 20 VlcWGsNsdGQ 30
                Vl+ G+N + Q
  EFC39909.1 30 VLSMGRNHCHQ 40
                99999999987 PP

  == domain 2  score: 0.4 bits;  conditional E-value: 0.069
      RCC1_2  11 scaLtedGe.VlcWGs 25 
                 s++Lt++ + ++ +Gs
  EFC39909.1  87 SVFLTSSRKhLFVCGS 102
                 7889998777999996 PP

  == domain 3  score: 12.7 bits;  conditional E-value: 9.7e-06
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsd 28 
                 +  G+ H ++Lt+ G++++ GsN +
  EFC39909.1 142 ITLGSEHLFVLTNKGKIYGLGSNKC 166
                 67799******************98 PP

  == domain 4  score: 10.1 bits;  conditional E-value: 6.2e-05
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 ++++ +G + ++++t+ + V++ G N++G
  EFC39909.1 191 IRKIVCGESCTFFITSANYVFASGLNNYG 219
                 67899***********************9 PP

  == domain 5  score: 20.3 bits;  conditional E-value: 3.8e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 ++++ +G++H+++  +dG ++++G+N  GQ
  EFC39909.1 242 IEDIYCGSSHTIFKKTDGSLYGCGNNLLGQ 271
                 68999*********************9999 PP

  == domain 6  score: 17.0 bits;  conditional E-value: 4.1e-07
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGs 25 
                 ++sv +G +++++L ++GeV+ +G 
  EFC39909.1 294 IVSVKCGENFTMFLNASGEVFVTGY 318
                 79**********************6 PP

  == domain 7  score: 12.1 bits;  conditional E-value: 1.5e-05
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWGsNsdG 29 
                 ++s+ +G++ + + t +G+V++ G Ns+G
  EFC39909.1 351 ITSIECGSDVAYFTTHNGDVYGAGANSYG 379
                 689*************************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (466 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       513  (0.0286129); expected 358.6 (0.02)
Passed bias filter:                      410  (0.022868); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.66u 0.30s 00:00:00.96 Elapsed: 00:00:00.50
# Mc/sec: 2785.25
//
Query:       EFC39910.1  [L=419]
Description: hypothetical protein NAEGRDRAFT_81162 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    5.2e-10   39.0   7.5    9.2e-10   38.2   7.5    1.4  1  ZZ        Zinc finger, ZZ type
    4.9e-07   29.6   0.0      1e-06   28.6   0.0    1.5  1  PB1       PB1 domain


Domain annotation for each model (and alignments):
>> ZZ  Zinc finger, ZZ type
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   38.2   7.5     1e-13   9.2e-10       2      40 ..     238     277 ..     237     281 .. 0.90

  Alignments for each domain:
  == domain 1  score: 38.2 bits;  conditional E-value: 1e-13
                 SS-EE-TTT-S..EESSEEEESSSSS-EE-HHHHHH..H- CS
          ZZ   2 hkkytCdgCseapligvRyhclrcsdYDLCqsCfst.hka 40 
                 h+++tCdgC++ +++g R++c  c+d+D C  Cf +  + 
  EFC39910.1 238 HFGVTCDGCGKYAFVGKRFKCDDCDDFDFCEDCFASeTVR 277
                 899*******************************985554 PP

>> PB1  PB1 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   28.6   0.0   1.1e-10     1e-06      23      74 ..      84     135 ..      74     146 .. 0.88

  Alignments for each domain:
  == domain 1  score: 28.6 bits;  conditional E-value: 1.1e-10
                 -HHHHHHHHHHHHTSTCCSEEEEEEETTSSEEEESSHHHHHHHHHHHHHTSS CS
         PB1  23 sfeeLrakvekrfklsdedvklkYpdedgdlVtitsDeDLeealeearslks 74 
                 ++ +L + + ++++l+ e+  + Y+d+++++V i+sDe+L   ++ +r+++ 
  EFC39910.1  84 NYADLTRYLTEKCGLTLENALIRYQDDENHWVDISSDEELAYGIQLCRESRT 135
                 799**************************************99999999744 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (419 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       747  (0.0416643); expected 358.6 (0.02)
Passed bias filter:                      502  (0.0279993); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.65u 0.34s 00:00:00.99 Elapsed: 00:00:00.55
# Mc/sec: 2300.47
//
Query:       EFC39911.1  [L=636]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
     1e-101  340.7  18.0   1.2e-101  340.4  18.0    1.1  1  FPN1      Ferroportin1 (FPN1)


Domain annotation for each model (and alignments):
>> FPN1  Ferroportin1 (FPN1)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  340.4  18.0  6.9e-106  1.2e-101       2     435 .]     143     601 ..     142     601 .. 0.91

  Alignments for each domain:
  == domain 1  score: 340.4 bits;  conditional E-value: 6.9e-106
        FPN1   2 salllLyvshllstwgdrmweFavslflaeLypnsLllvavyglveslsvlllgaivGklvdklarlkvlraslllqnlsvvvsaallvll..lvvksl 98 
                 ++l++ y+sh+l++wgdrmw+Fa++++   ++p++Ll+ a +g++++l  ++lg+ +G +vd+++r kv+   l++qn+sv++   l+ ll  +   s+
  EFC39911.1 143 RKLNVFYASHFLASWGDRMWAFALPVIFGDMFPETLLPMALMGFIQKLIGIILGPHMGYMVDTMPRFKVMSIALIVQNASVALTTLLIFLLgyFGWRSE 241
                 567899*****************************************************************************9988877622444444 PP

        FPN1  99 lae.............dsalltvlfvvvvllaavakLastaetiaieRdWvvvisgeesaklaklNavlrriDllckllapllvglllsfvslkiaigf 184
                  ++             +++l++vlf+   l++++  L+s+++++a ++dW  v++ +e+  l+++N+++rr+D+++ +++p+l+gl+l+f+++ki++++
  EFC39911.1 242 DSKpqtetdalfiwpfETVLSMVLFFSCALIGSLSDLSSMVTSVARTKDWCLVVARGEKLPLERINSMMRRLDMVSLIVSPVLFGLILTFAGYKIGAIV 340
                 444899********************************************************************************************* PP

        FPN1 185 ilvvnlvsvvveyillakvYrkvpalaekeekkeeeeeeakee.......etkakeaksesslvkrvaeavktv.vagWkeYvrqpvflaslalslLyl 275
                 ++ +n++s+v eyi ++ vY+++ +l+ ++ ++e + +e+ e         +++ + ++++++v+  +++v ++   gWk+Y+ q+vfl+sla ++L++
  EFC39911.1 341 VCLWNVFSLVPEYICIRYVYNNTKELHITKLEQELKIKEERERellaaneGMQQIDLEQKEETVNLKHQNVFKIlFMGWKSYLTQKVFLSSLAFVFLFI 439
                 ***************************99988888777777767899999444444455555555544444444389********************** PP

        FPN1 276 tVLsFdtlmtaylkseglsasvisllrgvsavtgilgTfafpllekrigllrtGlislvaqlsclllavasvllpg..spmskisvvlllagvalsRlG 372
                 tVL+   l  +ylks+ + ++v++ ++++sa+ g+l Tf++p l  ri + r Gl+sl +q+  l++ v  +++ +  s+  + +v+++l+g+++sRlG
  EFC39911.1 440 TVLTHSGLLLSYLKSHKIHSAVLGTFQALSAISGLLSTFIAPYLIMRINVFRGGLVSLYFQFFSLVAGVLCFIVFNfwSEQFYFAVYFFLIGIIMSRLG 538
                 *****************************************************************9877766655411233799*************** PP

        FPN1 373 lwsfdlavtqllQegvpesernvvggvqnslqslldllkfilviiapnpeeFgilvliSvvav 435
                 l++fdla +q++Q+ v++++ ++v++++ sl +++dl+ f  +++++ p+ F +l++ S+  v
  EFC39911.1 539 LYAFDLAEIQIMQQLVDQKDSGIVNSTEGSLTKIADLIVFFSALFFSTPSRFVFLACGSLCCV 601
                 ***********************************************************9876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (636 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1450  (0.0808746); expected 358.6 (0.02)
Passed bias filter:                      523  (0.0291706); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.78u 0.32s 00:00:01.10 Elapsed: 00:00:00.52
# Mc/sec: 3651.57
//
Query:       EFC39912.1  [L=652]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
     0.0013   18.6   0.7     0.0033   17.3   0.3    1.9  2  F-box-like  F-box-like


Domain annotation for each model (and alignments):
>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.3   0.3   1.9e-07    0.0033       6      35 ..      11      42 ..      11      46 .. 0.86
   2 ?   -3.5   0.0      0.56     1e+04      20      35 ..     344     359 ..     326     362 .. 0.75

  Alignments for each domain:
  == domain 1  score: 17.3 bits;  conditional E-value: 1.9e-07
  F-box-like  6 dEiLlqIFsyL.ppsdLlr.lalVCrrWrrva 35
                +++L++ ++   ++ ++++  +lVC++Wr+v 
  EFC39912.1 11 NDLLCYLLQNFaDFHEIVNsYSLVCKQWRSVS 42
                578899998666999****88*********96 PP

  == domain 2  score: -3.5 bits;  conditional E-value: 0.56
  F-box-like  20 dLlrlalVCrrWrrva 35 
                 ++ +l++ C   r++ 
  EFC39912.1 344 SIRNLSRLCLNLRSLS 359
                 6778888887777765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (652 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       681  (0.0379832); expected 358.6 (0.02)
Passed bias filter:                      378  (0.0210832); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.69u 0.36s 00:00:01.04 Elapsed: 00:00:00.57
# Mc/sec: 3471.59
//
Query:       EFC39913.1  [L=681]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    1.5e-74  251.5  14.5    1.9e-74  251.2  14.5    1.1  1  SGT1      SGT1 protein


Domain annotation for each model (and alignments):
>> SGT1  SGT1 protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  251.2  14.5   1.1e-78   1.9e-74       1     540 [.      48     627 ..      48     651 .. 0.79

  Alignments for each domain:
  == domain 1  score: 251.2 bits;  conditional E-value: 1.1e-78
        SGT1   1 veYklflkqedssdk.ekeeeklqelle........eilakvapllve.YiWqkdpFnLkvrtek...............gdlpahlgGvtkfGdnieD 74 
                 v Y++f+ q + +++ ++e++++++ +e        ei + +++ + e Y+Wq d Fn++ ++                 + + + + G+++f +   D
  EFC39913.1  48 VSYRIFIVQPELTSRfKDETKTIEDFNEelffekscEIHNFLKERIPEnYVWQGDMFNITFVSPPeqledcteemflrnnQPVYPYICGRVNFSETNID 146
                 6788887755443331344455555544111111115666666555335***********9988889***********999999***********999* PP

        SGT1  75 EWFiVyLlkeitkefp.elvarvedndgeflLieaaevlPkWln..PdtsenrvfiykGelhiipkssksseve....lkakep..slsqalellsknp 164
                 EWFi yLl e++k+f  ++v++++d+dgeflLieaa+++ +W+n  P+ ++nrvfiy+G+lhi+p + ++ + +     + ++p  ++++a+e++ +++
  EFC39913.1 147 EWFITYLLVELSKNFKdQVVVQISDQDGEFLLIEAADYIAEWMNdePELTTNRVFIYNGKLHILPDQPETPSYSyyevFPISKPiqNIHKAVEMVFRES 245
                 ***************725789*********************976699*****************87766555431122333333379*********** PP

        SGT1 165 eetlasesiqsaikkrlkgYp.ekikeslhrahvyvPasvaavLkqrPsLvapAVqaFylRdpvdlkacrtmktFpp...........etrvltsvtft 251
                 + +++++siq++i++rl+ +p e ++    +  +y+P  v+ +L+++P++v++ +     +++v+ k+++++ +F+p           +     sv++ 
  EFC39913.1 246 KYCQSEDSIQNCISTRLSSFPkEAVEFGSQKIACYLPLDVIRLLDKHPQIVSKCIYYLTRKNTVTEKFLKSFSRFLPtepssdngslrDYFTYYSVNVN 344
                 ********************82456778999***************************************************999998889999***** PP

        SGT1 252 rclYAqLvqqkf....tpdkrsgyklpsr.sdpeykaaelGmklAhGfEiLcskakkasseseselekekkwkaylesLkkkgYFkgelegSaeYkell 345
                 rc Y qL+  +     +p   s y+  ++ +d++ ka+elG k+ +G+E+ +   k+            ++++ y+++L ++gYF  e++g  ++++l+
  EFC39913.1 345 RCQYVQLISSRIdvndVPKLASIYRPSNKrTDKQEKAYELGFKILCGLEMYYHAEKPI--------DIFDSFEDYVDHLYDHGYFGLEMSGTDKFNNLV 435
                 *********9984444577789998665558999****************99887764........456689*************************** PP

        SGT1 346 ekAeeyfkqsvasssssasspgeeilelLksaleleleelkkeeeelppedddsWLeiseeeLdkllqeragekelveesskeeeasydleevtksmka 444
                 +k ++y+ +  ++      +    i + L + ++l+++e+k+++      d d+WL+  +ee++k  +++  +++     + e++ +++++++ +++k+
  EFC39913.1 436 TKSKTYYDEFGKT------ANCYFIEQALMEGSTLSMKEIKQRK---LIVDTDDWLDSANEEMEKYFSQKGFSES----GEGEQDIEKKAKDMMDKVKS 521
                 *******988765......5667788999899999*****9999...678999*************998876443....35678888999********* PP

        SGT1 445 Fldk.vSsheGaelPe...........skeekevsfdvdsflkalekllgskieeeldsddld.edssedsdeedeedeeee.eaeeeskeeekeslks 529
                 F+++  S++ G+ + +            ++++     + +  + l+++l+++  +   ++ ++  + +e++de+++ d++e+ + + e++e+ + ++++
  EFC39913.1 522 FIEEeESNIGGVKTKSkhktskddwsfISSSST----APNDQSRLDNFLKETFGKYPIEELIEkFNIEEEVDEDEDIDDNENdDDDWEDEETIDPEMED 616
                 **85279******95544443332222222222....2344556666666655444444333332333333333333333342557778888899**** PP

        SGT1 530 YmdqmdeELaq 540
                  m++md+EL q
  EFC39913.1 617 LMQKMDDELYQ 627
                 ********976 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (681 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1441  (0.0803726); expected 358.6 (0.02)
Passed bias filter:                      621  (0.0346366); expected 358.6 (0.02)
Passed Vit filter:                        49  (0.002733); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.83u 0.35s 00:00:01.18 Elapsed: 00:00:00.55
# Mc/sec: 3737.10
//
Query:       EFC39914.1  [L=253]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (253 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1051  (0.0586201); expected 358.6 (0.02)
Passed bias filter:                      532  (0.0296726); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.57u 0.32s 00:00:00.88 Elapsed: 00:00:00.51
# Mc/sec: 1485.42
//
Query:       EFC39915.1  [L=772]
Description: TLDc domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.3e-20   72.0  64.8    6.9e-05   22.9  11.2    6.6  5  Pentapeptide_4   Pentapeptide repeats (9 copies)
    7.8e-17   61.8   3.1    7.8e-17   61.8   3.1    3.4  3  TLD              TLD
    8.2e-11   41.3  31.7      4e-05   23.2   0.6    8.0  7  Pentapeptide     Pentapeptide repeats (8 copies)
    2.1e-09   37.4  56.2    0.00061   19.9   8.4    7.5  8  Pentapeptide_3   Pentapeptide repeats (9 copies)
    0.00031   21.0   0.1     0.0016   18.8   0.1    2.3  1  BTB_2            BTB/POZ domain
     0.0097   15.8   2.9     0.0097   15.8   2.9    2.9  2  Beta_helix       Right handed beta helix region
  ------ inclusion threshold ------
      0.016   15.6   2.3      0.029   14.7   2.3    1.3  1  CENP-B_dimeris   Centromere protein B dimerisation domain
      0.024   14.5   3.1       0.11   12.4   3.1    2.2  1  zf-RING_6        zf-RING of BARD1-type protein
      0.038   14.2   5.9      0.059   13.6   5.9    1.2  1  RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc3
      0.062   13.8   0.5        2.6    8.5   0.0    2.7  2  HTH_40           Helix-turn-helix domain
       0.43   11.3   7.2      0.092   13.4   3.6    1.7  2  FYDLN_acid       Protein of unknown function (FYDLN_acid)


Domain annotation for each model (and alignments):
>> Pentapeptide_4  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.56   9.2e+02      42      68 ..     276     292 ..     267     296 .. 0.52
   2 !   19.5  16.9     5e-07   0.00081       2      77 .]     297     386 ..     275     435 .. 0.70
   3 !   15.9  11.4   6.8e-06     0.011       8      60 ..     439     493 ..     436     498 .. 0.49
   4 !   22.9  11.2   4.2e-08   6.9e-05       2      69 ..     461     533 ..     457     534 .. 0.70
   5 !   21.6  12.9   1.1e-07   0.00018       3      61 ..     532     589 ..     530     603 .. 0.83

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.56
  Pentapeptide_4  42 nlsdvdfaevdlkrasFsgcnlknvnf 68 
                      +++            Fsg++++ ++f
      EFC39915.1 276 YFRNM----------KFSGMEIALITF 292
                     44444..........444444444444 PP

  == domain 2  score: 19.5 bits;  conditional E-value: 5e-07
  Pentapeptide_4   2 eftrcsfnncklsnvnFsearlrdcnFtecrl...............snvnFdecnlsdvdfaevdlkrasFsgcnlknvnfsd.klkdidF 77 
                     +f++c f ++++ nv F+++ +  +nF ++++                +++F +c+l+ + f++v  k+++ ++c+l+ ++fsd  +++ dF
      EFC39915.1 297 DFINCDFSKTTFRNVRFENCLIDKANFAGAKMiscrvqlqfnqsnniESCRFVNCTLDGSFFTGV--KSLQCKECTLNVCTFSDmDMRHFDF 386
                     56677777777777777777666666666666665655555444444333444444444444444..3445566666666665445555554 PP

  == domain 3  score: 15.9 bits;  conditional E-value: 6.8e-06
  Pentapeptide_4   8 fnncklsnvnFsea...rlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsg 60 
                     f +c++s+++F+++   +l++  F++c+l n  F++c+++ ++f+++++  ++F +
      EFC39915.1 439 FTECIFSDFTFENChleNLKNNKFKDCKLLNIGFSDCSFQ-TKFENCEIICVEFWR 493
                     4455555555555533334444555555555555555553.455555544444444 PP

  == domain 4  score: 22.9 bits;  conditional E-value: 4.2e-08
  Pentapeptide_4   2 eftrcsfnncklsnvnFsearlrdcnFtecrl......snvnFdecnlsdvdfaevdlkrasFsgcnlknvnfs 69 
                     +f++c+++n  +s+++F + ++++c +  + +       + +F e++l d+ f+e+++ +++F++ ++kn  f+
      EFC39915.1 461 KFKDCKLLNIGFSDCSFQT-KFENCEIICVEFwrcsfdREFVFPESQLYDITFTECSFHSINFENYQFKNLLFD 533
                     3555555555555555555.777777666666777778888888888888888888888888888888888885 PP

  == domain 5  score: 21.6 bits;  conditional E-value: 1.1e-07
  Pentapeptide_4   3 ftrcsfnncklsnvnFsearlrdcnFtecrlsnvnFdecnlsdvdfaevdlkrasFsgc 61 
                     f  c+f++++l+++nFs+++lr c+F ++++ ++ F+  n ++ d +  ++k++ F  +
      EFC39915.1 532 FDKCKFLDSNLKKCNFSTCKLRMCDFANSNFEQAIFNADN-DTFDCNSEKFKNIFFNSN 589
                     899*******************************997544.777777777777777665 PP

>> TLD  TLD
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.3      0.58   9.5e+02     103     138 ..     456     494 ..     430     495 .. 0.62
   2 ?   -0.5   0.3      0.78   1.3e+03      99     120 ..     537     567 ..     537     586 .. 0.55
   3 !   61.8   3.1   4.8e-20   7.8e-17       1     138 [.     612     770 ..     612     771 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.58
         TLD 103 slekgtsrhsetfengllsg.........aseerfkikdiEVWgl 138
                 +l++++++ +       l +         ++ e+ +i ++E W++
  EFC39915.1 456 NLKNNKFKDC------KLLNigfsdcsfqTKFENCEIICVEFWRC 494
                 4444444444......33334444444445667778999999987 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 0.78
         TLD  99 widsslekgtsrhs.........etfengll 120
                 ++ds+l+k+ ++++         + fe+ ++
  EFC39915.1 537 FLDSNLKKCNFSTCklrmcdfanSNFEQAIF 567
                 5777777777777755554444333333333 PP

  == domain 3  score: 61.8 bits;  conditional E-value: 4.8e-20
         TLD   1 llyssskdgsslstllekienkgptlllikdekkyifGaflsqpwkssnkkfygdsesflfsl......spkfkvyks...tgkn..kaylntssdglg 88 
                 lly+ s+dg+++s+++e ++nkgptl++i+++ ++ifG+f+ q+w +++ ++++d++ f+f++      +  + ++++   ++ +  +a+    s+ + 
  EFC39915.1 612 LLYRGSRDGFKASKFHELCDNKGPTLTIIQSDFGHIFGGFTMQSWANTGVEYVSDTSAFIFKIfqkvtsNGMVYIFNKfniKPGQhrFAISAKASYLPI 710
                 69***************************99999*****************************8888764445555556553222324444444555** PP

         TLD  89 fGggqpkfsLwidsslekgtsrhs...........etfengllsg..aseerfkikdiEVWgl 138
                 fGgg+   +++i ++++++  + s           + ++++++s+  a+  +f++ +iEV+++
  EFC39915.1 711 FGGGN---DFCIADNCNENLNSYSkfghtyylpdtGNYSSKSISKylAGCANFRVLEIEVFQI 770
                 ***86...7777776665433333355545555577788888877**999***********87 PP

>> Pentapeptide  Pentapeptide repeats (8 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.2   0.6   2.4e-08     4e-05       2      36 ..     297     331 ..     297     333 .. 0.94
   2 ?    4.1   0.1     0.023        37       6      20 ..     346     360 ..     342     362 .. 0.57
   3 ?    2.4   0.1     0.079   1.3e+02       6      20 ..     374     388 ..     365     390 .. 0.54
   4 ?    2.5   0.1     0.073   1.2e+02       8      24 ..     439     455 ..     438     458 .. 0.58
   5 ?   -0.2   0.0       0.5   8.1e+02      18      33 ..     481     496 ..     472     498 .. 0.60
   6 !   15.5   2.0   6.2e-06      0.01       3      39 ..     512     548 ..     512     548 .. 0.98
   7 !   13.3   1.8     3e-05     0.049       1      23 [.     545     567 ..     545     569 .. 0.64

  Alignments for each domain:
  == domain 1  score: 23.2 bits;  conditional E-value: 2.4e-08
                   B-TT-B-CCSCCEECCCESEEECT-B-TT-EECCE CS
  Pentapeptide   2 nLsgAnLsganLsganlsgAnLtgAnlsgAdLsga 36 
                   ++ ++++s + ++++ ++++  ++An+ gA++  +
    EFC39915.1 297 DFINCDFSKTTFRNVRFENCLIDKANFAGAKMISC 331
                   799***************************99877 PP

  == domain 2  score: 4.1 bits;  conditional E-value: 0.023
                   -B-CCSCCEECCCES CS
  Pentapeptide   6 AnLsganLsganlsg 20 
                   +++ ++ L+g++++g
    EFC39915.1 346 CRFVNCTLDGSFFTG 360
                   555566666666655 PP

  == domain 3  score: 2.4 bits;  conditional E-value: 0.079
                   -B-CCSCCEECCCES CS
  Pentapeptide   6 AnLsganLsganlsg 20 
                   + +s  ++++ ++s+
    EFC39915.1 374 CTFSDMDMRHFDFSN 388
                   445555555555555 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.073
                   -CCSCCEECCCESEEEC CS
  Pentapeptide   8 LsganLsganlsgAnLt 24 
                   ++++++s+  ++++ L 
    EFC39915.1 439 FTECIFSDFTFENCHLE 455
                   55566666666666554 PP

  == domain 5  score: -0.2 bits;  conditional E-value: 0.5
                   CESEEECT-B-TT-EE CS
  Pentapeptide  18 lsgAnLtgAnlsgAdL 33 
                   ++++  +++++ ++ +
    EFC39915.1 481 FENCEIICVEFWRCSF 496
                   5555555555555555 PP

  == domain 6  score: 15.5 bits;  conditional E-value: 6.2e-06
                   -TT-B-CCSCCEECCCESEEECT-B-TT-EECCEEEC CS
  Pentapeptide   3 LsgAnLsganLsganlsgAnLtgAnlsgAdLsganLs 39 
                   ++++ ++  n+++  +++  ++++ + +++L+ +n+s
    EFC39915.1 512 FTECSFHSINFENYQFKNLLFDKCKFLDSNLKKCNFS 548
                   899*********************************7 PP

  == domain 7  score: 13.3 bits;  conditional E-value: 3e-05
                   -B-TT-B-CCSCCEECCCESEEE CS
  Pentapeptide   1 AnLsgAnLsganLsganlsgAnL 23 
                   +n+s + L+ +++ ++n+++A +
    EFC39915.1 545 CNFSTCKLRMCDFANSNFEQAIF 567
                   66666666666666666666666 PP

>> Pentapeptide_3  Pentapeptide repeats (9 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.7   1.7   4.4e-07   0.00072      12      42 ..     298     326 ..     290     332 .. 0.58
   2 !    7.4   0.8    0.0029       4.7      17      40 ..     337     360 ..     336     365 .. 0.73
   3 ?    5.0   5.4     0.017        28       1      46 [.     348     388 ..     343     390 .. 0.47
   4 !    6.2   1.3     0.007        11      12      29 ..     439     455 ..     428     458 .. 0.61
   5 ?    4.6   6.6     0.022        35       1      46 [.     439     483 ..     439     484 .. 0.80
   6 !    6.6   1.4    0.0053       8.7       1      40 [.     462     498 ..     457     506 .. 0.89
   7 !    7.2   0.3    0.0035       5.6       1      25 [.     502     524 ..     502     530 .. 0.84
   8 !   19.9   8.4   3.8e-07   0.00061       1      43 [.     532     572 ..     532     577 .. 0.92

  Alignments for each domain:
  == domain 1  score: 19.7 bits;  conditional E-value: 4.4e-07
  Pentapeptide_3  12 FrgatFsgaasFsnadFgsadFsgarFtgdv 42 
                     F ++ Fs+++ F+n +F+++  ++a+F  ++
      EFC39915.1 298 FINCDFSKTT-FRNVRFENCLIDKANFA-GA 326
                     5555555553.55555555555555554.33 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0029
  Pentapeptide_3  17 FsgaasFsnadFgsadFsgarFtg 40 
                     F+++ + ++++F +++++g+ Ftg
      EFC39915.1 337 FNQSNNIESCRFVNCTLDGSFFTG 360
                     677777777888888888887773 PP

  == domain 3  score: 5.0 bits;  conditional E-value: 0.017
  Pentapeptide_3   1 FsganFsgaadFr........gatFsgaasFsnadFgsadFsgarFtgdvdFsg 46 
                     F++++++g+ +F+        +           ++++ ++Fs+  +    dFs+
      EFC39915.1 348 FVNCTLDGS-FFTgvkslqckE-----------CTLNVCTFSDMDMR-HFDFSN 388
                     556666666.666333333333...........44444444444444.444444 PP

  == domain 4  score: 6.2 bits;  conditional E-value: 0.007
  Pentapeptide_3  12 FrgatFsgaasFsnadFg 29 
                     F+++ Fs+ + F+n++++
      EFC39915.1 439 FTECIFSDFT-FENCHLE 455
                     6666666663.6666554 PP

  == domain 5  score: 4.6 bits;  conditional E-value: 0.022
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaas..FsnadFgsadFsgarFtgdvdFsg 46 
                     F++++Fs+  +F++++ ++  +  F+++ + ++ Fs++ F   + F++
      EFC39915.1 439 FTECIFSDF-TFENCHLENLKNnkFKDCKLLNIGFSDCSFQ--TKFEN 483
                     89999****.*****99999944699999888888888884..55555 PP

  == domain 6  score: 6.6 bits;  conditional E-value: 0.0053
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFtg 40 
                     F+++ + +   F+++ F+    F+n+ +  + F ++ F++
      EFC39915.1 462 FKDCKLLNI-GFSDCSFQTK--FENCEIICVEFWRCSFDR 498
                     889999999.9999999999..99*999999999999986 PP

  == domain 7  score: 7.2 bits;  conditional E-value: 0.0035
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsn 25 
                     F ++++++  +F+++ F++  +F+n
      EFC39915.1 502 FPESQLYDI-TFTECSFHSI-NFEN 524
                     678999999.9999999999.8987 PP

  == domain 8  score: 19.9 bits;  conditional E-value: 3.8e-07
  Pentapeptide_3   1 FsganFsgaadFrgatFsgaasFsnadFgsadFsgarFtgdvd 43 
                     F+ + F ++ ++ +++Fs +   + +dF +++F+ a+F+ d d
      EFC39915.1 532 FDKCKFLDS-NLKKCNFSTC-KLRMCDFANSNFEQAIFNADND 572
                     99*******.**********.7*****************9866 PP

>> BTB_2  BTB/POZ domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.1   9.6e-07    0.0016       3      68 ..     159     227 ..     157     240 .. 0.79

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 9.6e-07
                 EEETTEEEEEEHHHHHTS....TTSTTTSSGG....GGEETTTTEEEE-S-HHHHHHHHHHHHS.S-B-- CS
       BTB_2   3 lnVgGtrfetskstLsrk....pdtlLgkllkteelddydeetneyffDRspklFetiLnyyrtggkLhr 68 
                  n+gG    t+k+  +       + l+ kllk e+++ ++e+++++f+D +p++F+++L++++  g++  
  EFC39915.1 159 FNIGGQLIMTNKKYFTSTkredETNLFIKLLKGERTNIFTEKNGSFFVDCDPTVFKHLLEWFKF-GNIIA 227
                 79***999999986654322225567889999999*************************9998.55554 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.8   2.9   5.9e-06    0.0097      39     149 ..     301     425 ..     261     434 .. 0.67
   2 !    8.4  12.2    0.0011       1.8      11     134 ..     311     486 ..     304     608 .. 0.74

  Alignments for each domain:
  == domain 1  score: 15.8 bits;  conditional E-value: 5.9e-06
                 -EEES-SS-SEEE-TT.-S-EEES-EEE---............SEEE-TT--S--EEES-EEES-SS-SEE-TT-S--EEES-EEESTT--SEE---TT CS
  Beta_helix  39 neiannsgsGiyilgs.snntisnntisdnn............gggialfgasnnlienneitdnggsGiylnyssnntienNiidnnagsGividdss 124
                 +              + s++t++n +++++             +  + l+ ++ n ie +++ ++  +G ++++ ++++ ++++++ ++ s + ++  +
  EFC39915.1 301 C--------------DfSKTTFRNVRFENCLidkanfagakmiSCRVQLQFNQSNNIESCRFVNCTLDGSFFTGVKSLQCKECTLNVCTFSDMDMRHFD 385
                 3..............244444444444444444444666669999999999999999999999999999999999999999999999998888888888 PP

                 ---EEES-EEES-S...............SEEEE-TT-SS CS
  Beta_helix 125 snvtvtnNtitnnk...............gaGiavvgsss 149
                  ++t++++t++++                + Gi+v +s+ 
  EFC39915.1 386 FSNTIKGSTLKKCQinlskispdllnsltIQGIEVKHSQI 425
                 7888899988887766666666666666666666666655 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0011
                 .EEESEEEES-SS-SEEE-SSS-.............EEES-EEES-SS-SEEE-TT-S-EEES-EEE---................SEEE-TT--S--E CS
  Beta_helix  11 vtiknntisnsggyGiylrgssn............vvienneiannsgsGiyilgssnntisnntisdnn................gggialfgasnnl 81 
                 v ++n+ i++++ +G +  +++             +++ n+++ ++ ++G+  l+++++t+  +t+sd                     i+l++ s+ l
  EFC39915.1 311 VRFENCLIDKANFAGAKMISCRVqlqfnqsnniesCRFVNCTLDGSFFTGVKSLQCKECTLNVCTFSDMDmrhfdfsntikgstlkKCQINLSKISPDL 409
                 445555555555555555555555555555446666666666666888888888888888888888888877666666666666666666666666666 PP

                 EES-EEES-...........SS-..............SEE-TT-S--EEES-EEESTT--SEE---TT---EEES-EE CS
  Beta_helix  82 ienneitdn...........ggs..............GiylnyssnntienNiidnnagsGividdsssnvtvtnNti 134
                 ++  +i              + +               +++++++   ++nN +++++   i ++d s +++++n+ i
  EFC39915.1 410 LNSLTIQGIevkhsqigslfE-TnlnlaycftecifsDFTFENCHLENLKNNKFKDCKLLNIGFSDCSFQTKFENCEI 486
                 666666666555444333330.03333333333334455555577777777777777766666666666666677765 PP

>> CENP-B_dimeris  Centromere protein B dimerisation domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.7   2.3   1.8e-05     0.029       6      76 ..     116     189 ..     112     203 .. 0.60

  Alignments for each domain:
  == domain 1  score: 14.7 bits;  conditional E-value: 1.8e-05
  CENP-B_dimeris   6 leagedsesesdeeeee...eeedeededeeddedddevpvpsfgeamayfamvkryltsfpiddrvqshilhl 76 
                     le  e  + e+ ee e+   eee+ ede e+dd+d+ e+    f      +   k+y+ts   +d  +  i  l
      EFC39915.1 116 LEEIERKQKEAVEEAEKkqvEEEQSEDEFEDDDDDEMELDPIYFNIGGQLIMTNKKYFTSTKREDETNLFIKLL 189
                     55556566665555444111455555666666666666554455555555666799***999999887776555 PP

>> zf-RING_6  zf-RING of BARD1-type protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.4   3.1   6.7e-05      0.11       5      48 ..      26      67 ..      22      74 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 6.7e-05
   zf-RING_6  5 ekllrcsrctdilrepvclggcehifcsncisdcfgsgcpvcyt 48
                e    cs c+  l +pv    ce +fc  c      s cp c+ 
  EFC39915.1 26 EEEWLCSSCSLPLSDPVFHTICENMFCLACAKSL--STCPKCHD 67
                55667*************************8764..89999975 PP

>> RNA_pol_3_Rpc31  DNA-directed RNA polymerase III subunit Rpc31
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   5.9   3.6e-05     0.059     159     212 ..     104     151 ..      57     160 .. 0.60

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 3.6e-05
  RNA_pol_3_Rpc31 159 eadeedeegkelleklkelaeeeddeeekkekedeeeeeeeeeddefddddedg 212
                      e+ ee  + k +le+++++++e  +     e+e+++ e ee+ +def+ddd+d+
       EFC39915.1 104 EHLEECSTRKTILEEIERKQKEAVE-----EAEKKQVE-EEQSEDEFEDDDDDE 151
                      3345555666667776654444444.....22222222.366789999888753 PP

>> HTH_40  Helix-turn-helix domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.1   0.4      0.17   2.7e+02      27      64 ..     100     135 ..      96     165 .. 0.54
   2 ?    8.5   0.0    0.0016       2.6      28      69 ..     211     255 ..     209     267 .. 0.78

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.17
      HTH_40  27 sTIegHLaelieegeeidlerlvseeeekeIeeaiek.v 64 
                 + I +HL e+   +    + + +++++++++eea +k v
  EFC39915.1 100 GRILEHLEECSTRKT---ILEEIERKQKEAVEEAEKKqV 135
                 568999999999963...333344455555554444321 PP

  == domain 2  score: 8.5 bits;  conditional E-value: 0.0016
      HTH_40  28 TIegHLaelieegeeidlerlvseeeekeIeeaiekvgsek....l 69 
                 T+ +HL+e  + g+ i  ++l s+  ++++++a++ ++ ++    l
  EFC39915.1 211 TVFKHLLEWFKFGNIIASSDL-SPTLKQQLISACKVFKLKNywkeL 255
                 9************97777776.889999999999999844442233 PP

>> FYDLN_acid  Protein of unknown function (FYDLN_acid)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.1       6.3     1e+04      28      34 ..      61      67 ..      59      81 .. 0.67
   2 ?   13.4   3.6   5.7e-05     0.092      27      89 ..      88     151 ..      83     181 .. 0.54

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 6.3
  FYDLN_acid 28 vcpkcge 34
                +cpkc++
  EFC39915.1 61 TCPKCHD 67
                6888875 PP

  == domain 2  score: 13.4 bits;  conditional E-value: 5.7e-05
  FYDLN_acid  27 ivcpkcgeefepeev......lksraaaaeaeeakkkkeeeedeedeeeeedvsdedadeeeee.ddddd 89 
                 +vc +c++e    ++        +r++  e+ e+k+k+     + +e+ e+++ +e++ e+e e dddd+
  EFC39915.1  88 VVCSYCNKEEARGRIlehleeCSTRKTILEEIERKQKE-----AVEEA-EKKQVEEEQSEDEFEdDDDDE 151
                 79999999998888843332222222222222222222.....22222.222222233333322022332 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (772 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1815  (0.101233); expected 358.6 (0.02)
Passed bias filter:                      727  (0.0405488); expected 358.6 (0.02)
Passed Vit filter:                       105  (0.00585643); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              11  [number of targets reported over threshold]
# CPU time: 0.89u 0.37s 00:00:01.26 Elapsed: 00:00:00.55
# Mc/sec: 4239.26
//
Query:       EFC39916.1  [L=680]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.1e-30  103.7  28.6    1.4e-09   37.6   0.0    9.5 10  DUF4116   Domain of unknown function (DUF4116)


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    2.1   0.3    0.0092   1.7e+02       1      26 [.     118     144 ..      98     165 .. 0.71
   2 ?   -2.4   0.0      0.23     4e+03      23      31 ..     195     203 ..     192     227 .. 0.69
   3 !   37.6   0.0   7.6e-14   1.4e-09       3      49 .]     231     277 ..     229     277 .. 0.97
   4 !    8.5   0.0   8.8e-05       1.6       6      26 ..     284     304 ..     283     315 .. 0.95
   5 !   11.6   0.3   9.6e-06      0.17       2      33 ..     323     356 ..     322     356 .. 0.91
   6 !   16.2   0.6   3.5e-07    0.0064       1      49 []     371     419 ..     371     419 .. 0.84
   7 !   11.4   0.0   1.1e-05       0.2      20      44 ..     446     470 ..     441     472 .. 0.91
   8 !   36.3   0.0   1.9e-13   3.3e-09       1      49 []     452     499 ..     452     499 .. 0.97
   9 !    2.6   0.1    0.0064   1.2e+02       1      17 [.     526     542 ..     504     562 .. 0.82
  10 ?    1.8   0.1     0.011     2e+02       1      38 [.     572     618 ..     572     626 .. 0.77

  Alignments for each domain:
  == domain 1  score: 2.1 bits;  conditional E-value: 0.0092
     DUF4116   1 DrEivleavkkngsalkyls.eeLknD 26 
                 D+E++ ++v++n   + +ls  ++++ 
  EFC39916.1 118 DEELIYKIVENNFTLFAKLSaISFTKE 144
                 566666666666554444444444444 PP

  == domain 2  score: -2.4 bits;  conditional E-value: 0.23
     DUF4116  23 LknDkeivl 31 
                 + nD +++ 
  EFC39916.1 195 ILNDEDFME 203
                 578888875 PP

  == domain 3  score: 37.6 bits;  conditional E-value: 7.6e-14
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 E+++e ++ +g++l+++s +L+n + +v  A+ +n +a+ +a e+Lr
  EFC39916.1 231 EFMKEFIEFDGMNLRFASGKLRNEWSFVEIALSNNVNAYQFATENLR 277
                 9********************************************98 PP

  == domain 4  score: 8.5 bits;  conditional E-value: 8.8e-05
     DUF4116   6 leavkkngsalkylseeLknD 26 
                 leavkk    l+y+ ++L++D
  EFC39916.1 284 LEAVKKSTDTLQYIGSNLRSD 304
                 99*****************99 PP

  == domain 5  score: 11.6 bits;  conditional E-value: 9.6e-06
     DUF4116   2 rEivleavkkngsalkyls..eeLknDkeivlkA 33 
                 +++v  ++  n++++  ++  +e++ Dk+++l A
  EFC39916.1 323 KDFVISLINYNPKNYLLIPldSEYRLDKDVMLLA 356
                 89***************76559*********976 PP

  == domain 6  score: 16.2 bits;  conditional E-value: 3.5e-07
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 Dr ++ e ++k  +  ky++e+ +nD+e ++ +++ n+  ++yas e+r
  EFC39916.1 371 DRNLIREMMSKLKKPSKYFDESCQNDFEMIKGCMRLNPQLFRYASIEIR 419
                 66666666666655669****************************8887 PP

  == domain 7  score: 11.4 bits;  conditional E-value: 1.1e-05
     DUF4116  20 seeLknDkeivlkAvkqngtalsya 44 
                 s+e+k++k+++l++v + g++l y+
  EFC39916.1 446 SHEIKQNKNFALRCVGKFGSSLQYL 470
                 89********************997 PP

  == domain 8  score: 36.3 bits;  conditional E-value: 1.9e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++ ++l +v k+gs+l+yl   + nDke+v+kAv+q+  ++s+ase L+
  EFC39916.1 452 NKNFALRCVGKFGSSLQYLR-HFWNDKEVVMKAVEQDFQSFSFASETLK 499
                 799****************9.8************************997 PP

  == domain 9  score: 2.6 bits;  conditional E-value: 0.0064
     DUF4116   1 DrEivleavkkngsalk 17 
                 D E+  e+v+k++++l+
  EFC39916.1 526 DLEFLEECVTKHNLYLY 542
                 77888888888877654 PP

  == domain 10  score: 1.8 bits;  conditional E-value: 0.011
     DUF4116   1 DrEivleavkkngs........alkylseeLknDk.eivlkAvkqng 38 
                 D+E +l++++k  +        ++ y  +++ n++  ++ +A+k n+
  EFC39916.1 572 DEETCLKILEKKENfqlytrftHFLYRKNRWNNNRpSFLERACKVNP 618
                 899999**999988787777666666667777777888888888887 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (680 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       940  (0.052429); expected 358.6 (0.02)
Passed bias filter:                      480  (0.0267723); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.55u 0.24s 00:00:00.79 Elapsed: 00:00:00.41
# Mc/sec: 5017.07
//
Query:       EFC39917.1  [L=650]
Description: hypothetical protein NAEGRDRAFT_72272 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.2e-07   29.2  40.8      0.052   13.6   0.3   10.9 12  LRR_6       Leucine Rich repeat
    4.3e-05   23.2  46.9      0.088   12.6   7.8    9.0  8  LRR_8       Leucine rich repeat
    0.00019   21.8  69.8      0.062   13.7   0.6   10.6 11  LRR_4       Leucine Rich repeats (2 copies)
     0.0034   17.3   0.0      0.011   15.6   0.0    1.9  1  F-box-like  F-box-like
  ------ inclusion threshold ------
       0.82    9.2  29.3       0.18   11.3   0.9    5.0  6  LRR_9       Leucine-rich repeat


Domain annotation for each model (and alignments):
>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.2   0.0     0.015        55       8      16 ..      89      97 ..      84      98 .. 0.84
   2 ?    0.1   0.1      0.32   1.1e+03       4      18 ..     138     152 ..     137     155 .. 0.89
   3 !    9.9   0.5   0.00023      0.83       2      17 ..     163     178 ..     162     181 .. 0.89
   4 ?   -1.3   0.1      0.91   3.3e+03       2      10 ..     242     250 ..     241     253 .. 0.89
   5 !    8.2   0.3   0.00077       2.8       2      16 ..     267     281 ..     266     283 .. 0.89
   6 ?   -1.8   0.1       1.2   4.4e+03       3      13 ..     294     304 ..     292     306 .. 0.86
   7 ?   -1.6   0.0       1.1   3.8e+03       3      16 ..     445     458 ..     443     459 .. 0.83
   8 !    7.2   0.3    0.0016       5.9       8      24 .]     475     491 ..     469     491 .. 0.81
   9 !   13.6   0.3   1.5e-05     0.052       1      23 [.     493     515 ..     493     515 .. 0.92
  10 ?   -2.7   0.0       2.5     9e+03       3      15 ..     522     535 ..     521     537 .. 0.73
  11 !    6.2   0.0    0.0035        12       3      23 ..     584     604 ..     582     605 .. 0.86
  12 ?    1.6   0.1       0.1   3.7e+02       8      20 ..     617     629 ..     615     632 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.2 bits;  conditional E-value: 0.015
       LRR_6  8 LdLsgNdIg 16
                L+Ls+N+I+
  EFC39917.1 89 LNLSFNCID 97
                9******97 PP

  == domain 2  score: 0.1 bits;  conditional E-value: 0.32
       LRR_6   4 hLteLdLsgNdIgDe 18 
                 + ++L+L+ + ++D+
  EFC39917.1 138 TFESLELMNCSLNDD 152
                 6789******99996 PP

  == domain 3  score: 9.9 bits;  conditional E-value: 0.00023
       LRR_6   2 nthLteLdLsgNdIgD 17 
                  ++Lt+Ld+++N I+ 
  EFC39917.1 163 LQNLTKLDVRSNRITT 178
                 589***********96 PP

  == domain 4  score: -1.3 bits;  conditional E-value: 0.91
       LRR_6   2 nthLteLdL 10 
                 n+++t+L+L
  EFC39917.1 242 NNTITSLSL 250
                 99*****97 PP

  == domain 5  score: 8.2 bits;  conditional E-value: 0.00077
       LRR_6   2 nthLteLdLsgNdIg 16 
                  ++L++L+Ls N +g
  EFC39917.1 267 LSNLKYLNLSKNRLG 281
                 589*********998 PP

  == domain 6  score: -1.8 bits;  conditional E-value: 1.2
       LRR_6   3 thLteLdLsgN 13 
                 ++L+eL L +N
  EFC39917.1 294 RNLEELILESN 304
                 79****99998 PP

  == domain 7  score: -1.6 bits;  conditional E-value: 1.1
       LRR_6   3 thLteLdLsgNdIg 16 
                  +L++L + ++ ++
  EFC39917.1 445 KKLRKLKMFSCSLT 458
                 5899**99999887 PP

  == domain 8  score: 7.2 bits;  conditional E-value: 0.0016
       LRR_6   8 LdLsgNdIgDeGaeaLa 24 
                 L L +N+Ig+eG+  ++
  EFC39917.1 475 LILCDNNIGNEGLYNIC 491
                 66679********9887 PP

  == domain 9  score: 13.6 bits;  conditional E-value: 1.5e-05
       LRR_6   1 snthLteLdLsgNdIgDeGaeaL 23 
                 ++++L++Ld+  N+Ig +G++ L
  EFC39917.1 493 NCCNLRSLDVENNGIGIDGVKYL 515
                 69***************999865 PP

  == domain 10  score: -2.7 bits;  conditional E-value: 2.5
       LRR_6   3 thLteLdLsgNd.I 15 
                 ++L +L+L   + I
  EFC39917.1 522 SKLAYLNLGNSQeI 535
                 57889999876655 PP

  == domain 11  score: 6.2 bits;  conditional E-value: 0.0035
       LRR_6   3 thLteLdLsgNdIgDeGaeaL 23 
                 ++L  L L +N+I D Gae +
  EFC39917.1 584 PNLSILVLYDNNICDRGAEVF 604
                 678899999*********976 PP

  == domain 12  score: 1.6 bits;  conditional E-value: 0.1
       LRR_6   8 LdLsgNdIgDeGa 20 
                  d+s Nd++D G+
  EFC39917.1 617 FDVSNNDMTDYGV 629
                 59********775 PP

>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.7   0.2   0.00083         3      25      57 ..      84     117 ..      78     118 .. 0.78
   2 !    8.2   0.5   0.00058       2.1      21      39 ..     160     178 ..     140     186 .. 0.84
   3 !   12.6   7.8   2.4e-05     0.088      22      59 ..     265     304 ..     243     306 .. 0.83
   4 !    4.9   0.7    0.0063        23       1      36 [.     294     330 ..     294     342 .. 0.88
   5 ?    2.9   0.2     0.026        93      13      55 ..     382     423 ..     380     429 .. 0.73
   6 ?    3.7   2.0     0.015        53       2      61 .]     446     507 ..     445     507 .. 0.79
   7 !    5.0   0.8    0.0056        20       2      37 ..     496     535 ..     495     540 .. 0.69
   8 !    7.8   0.1   0.00079       2.8       2      38 ..     558     597 ..     557     616 .. 0.76

  Alignments for each domain:
  == domain 1  score: 7.7 bits;  conditional E-value: 0.00083
                 TT--EEE--SS---GGG.GGGGTT--S-.EEE-- CS
       LRR_8  25 snLkvLdLsnNllttls.pgafsgLpsLrsLdLs 57 
                 +++k+L+Ls N+++  + +   s L sLr+L L+
  EFC39917.1  84 KKVKMLNLSFNCIDYCHfETLTSRLQSLRHLCLN 117
                 789***********96514555789999999775 PP

  == domain 2  score: 8.2 bits;  conditional E-value: 0.00058
                 STT-TT--EEE--SS---G CS
       LRR_8  21 FkglsnLkvLdLsnNlltt 39 
                  k+l+nL+ Ld ++N++tt
  EFC39917.1 160 CKNLQNLTKLDVRSNRITT 178
                 5789999999999999987 PP

  == domain 3  score: 12.6 bits;  conditional E-value: 2.4e-05
                 TT-TT--EEE--SS---G..GGGGGGTT--S-.EEE--SS CS
       LRR_8  22 kglsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsgN 59 
                 ++lsnLk+L+Ls N+l    l  + +  L++L++L L++N
  EFC39917.1 265 NKLSNLKYLNLSKNRLGQdfLVLNDCFTLRNLEELILESN 304
                 45************99766799*****************9 PP

  == domain 4  score: 4.9 bits;  conditional E-value: 0.0063
                 TT-SEEE-TTS-.-SEE-TTSSTT-TT--EEE--SS- CS
       LRR_8   1 pnLtsLdLsnNr.ltslddeaFkglsnLkvLdLsnNl 36 
                 +nL++L+L +N   ++ ++    +++nLk ++L  N+
  EFC39917.1 294 RNLEELILESNFiAHETCQLLIDKFENLKLFSLLGNN 330
                 79**********8899999999999999999997775 PP

  == domain 5  score: 2.9 bits;  conditional E-value: 0.026
                 -SEE-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE CS
       LRR_8  13 ltslddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLd 55 
                 ++s +  +F++ ++L+++ L +N l + +  g+   L +L+++ 
  EFC39917.1 382 IHSFSHNFFRTTKSLQIFTLIDNeLFEKI--GTSKVLGNLEEIE 423
                 77888999***************444445..5666666666655 PP

  == domain 6  score: 3.7 bits;  conditional E-value: 0.015
                 T-SEEE-TTS--SEE-TTSSTT.-TT--EEE--SS---G..GGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkg.lsnLkvLdLsnNlltt..lspgafsgLpsLrsLdLsgNrL 61 
                 +L++L   + +lt+ +  + ++ l+n+  L L +N++    l  + + ++ +LrsLd+++N +
  EFC39917.1 446 KLRKLKMFSCSLTGFPSIFNSTiLRNMSQLILCDNNIGNegLY-NICTNCCNLRSLDVENNGI 507
                 6888888888888888888788999999999999999766686.55555559*****999976 PP

  == domain 7  score: 5.0 bits;  conditional E-value: 0.0056
                 T-SEEE-TTS--SEE-T...TSSTT-TT--EEE--SS.-- CS
       LRR_8   2 nLtsLdLsnNrltsldd...eaFkglsnLkvLdLsnN.ll 37 
                 nL+sLd+ nN +   +    ++ k++s+L +L+L+n  ++
  EFC39917.1 496 NLRSLDVENNGIGIDGVkylTSCKTMSKLAYLNLGNSqEI 535
                 7899999999855444411134566999*****9998555 PP

  == domain 8  score: 7.8 bits;  conditional E-value: 0.00079
                 T-SEEE-TTS--SEE-TTSS...TT-TT--EEE--SS--- CS
       LRR_8   2 nLtsLdLsnNrltslddeaF...kglsnLkvLdLsnNllt 38 
                 nL sL  + N +t+++ +     +gl+nL +L L +N++ 
  EFC39917.1 558 NLVSLFCCGNTITAISAQYIvskSGLPNLSILVLYDNNIC 597
                 6778888888888888886633357999999999999985 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.6   2.6     0.013        47       2      31 ..      85     117 ..      84     148 .. 0.81
   2 !    6.2   3.1    0.0041        15      22      37 ..     163     177 ..     140     215 .. 0.67
   3 !   11.2   6.3   0.00011      0.39       4      36 ..     246     280 ..     239     288 .. 0.79
   4 !    7.2  10.5     0.002         7       2      36 ..     269     306 ..     268     340 .. 0.87
   5 ?   -1.8   0.0       1.4   4.8e+03      19      39 ..     390     410 ..     382     418 .. 0.74
   6 ?    3.5   0.1     0.028     1e+02       2      42 ..     418     460 ..     417     465 .. 0.66
   7 ?    4.9   0.9      0.01        37       1      36 [.     445     482 ..     445     489 .. 0.84
   8 !   11.4   2.0   9.8e-05      0.35       6      38 ..     475     508 ..     470     514 .. 0.79
   9 !   12.4   0.7   4.5e-05      0.16       1      39 [.     495     535 ..     495     543 .. 0.77
  10 !   13.7   0.6   1.7e-05     0.062       2      34 ..     558     595 ..     557     599 .. 0.83
  11 ?   -2.1   0.1       1.7     6e+03       7      17 ..     618     628 ..     615     639 .. 0.72

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.013
                 S--EEE--SS---.E-S-..HHH.-TT--EEE-. CS
       LRR_4   2 nLevLdLsnNqlt.dipl..lek.lpnLkeLdLs 31 
                 + + L+Ls N++     +  l + l +L++L L+
  EFC39917.1  85 KVKMLNLSFNCIDyC-HFetLTSrLQSLRHLCLN 117
                 7789****99**944.334655779999999884 PP

  == domain 2  score: 6.2 bits;  conditional E-value: 0.0041
                 -TT--EEE-.-S---- CS
       LRR_4  22 lpnLkeLdLsgNnlit 37 
                 l nL++Ld+ + n+it
  EFC39917.1 163 LQNLTKLDV-RSNRIT 177
                 555555555.333442 PP

  == domain 3  score: 11.2 bits;  conditional E-value: 0.00011
                 -EEE--SS---E-S-...HHH-TT--EEE-.-S--- CS
       LRR_4   4 evLdLsnNqltdipl...leklpnLkeLdLsgNnli 36 
                 ++L+L ++ l++ +    l+kl nLk+L+Ls N ++
  EFC39917.1 246 TSLSLIQCSLKKYDIiplLNKLSNLKYLNLSKN-RL 280
                 567777777777777776779*********999.55 PP

  == domain 4  score: 7.2 bits;  conditional E-value: 0.002
                 S--EEE--SS---.E-S-..HH...H-TT--EEE-.-S--- CS
       LRR_4   2 nLevLdLsnNqlt.dipl..le...klpnLkeLdLsgNnli 36 
                 nL++L+Ls N+l  d  +  l+    l nL+eL L +N +i
  EFC39917.1 269 NLKYLNLSKNRLGqD--FlvLNdcfTLRNLEELILESN-FI 306
                 9************55..644558877*******99666.65 PP

  == domain 5  score: -1.8 bits;  conditional E-value: 1.4
                 HHH-TT--EEE-.-S-----G CS
       LRR_4  19 leklpnLkeLdLsgNnlitdl 39 
                 ++  ++L+ ++L +N l +++
  EFC39917.1 390 FRTTKSLQIFTLIDNELFEKI 410
                 556789999999888555666 PP

  == domain 6  score: 3.5 bits;  conditional E-value: 0.028
                 S--EEE--SS---E-S-....HH..H-TT--EEE-.-S-----GGGG CS
       LRR_4   2 nLevLdLsnNqltdipl....le..klpnLkeLdLsgNnlitdldeL 42 
                 nLe++  +++ + +++     ++  +l++L++L + ++    +l+++
  EFC39917.1 418 NLEEIEVNDCSVITLEMmsslFKseSLKKLRKLKMFSC----SLTGF 460
                 67777777777666666655422447999999998556....66555 PP

  == domain 7  score: 4.9 bits;  conditional E-value: 0.01
                 SS--EEE--SS---E-S-.HH.H.-TT--EEE-.-S--- CS
       LRR_4   1 pnLevLdLsnNqltdipl.le.k.lpnLkeLdLsgNnli 36 
                 ++L++L  +++ lt +p+ ++   l n+ +L L +N +i
  EFC39917.1 445 KKLRKLKMFSCSLTGFPSiFNsTiLRNMSQLILCDN-NI 482
                 69****************988867999***998777.34 PP

  == domain 8  score: 11.4 bits;  conditional E-value: 9.8e-05
                 EE--SS---E-S-HH...H-TT--EEE-.-S----- CS
       LRR_4   6 LdLsnNqltdiplle...klpnLkeLdLsgNnlitd 38 
                 L L +N++   +l +   ++ nL++Ld+ +Nn i  
  EFC39917.1 475 LILCDNNIGNEGLYNictNCCNLRSLDV-ENNGI-G 508
                 88999****7666446668*********.77788.4 PP

  == domain 9  score: 12.4 bits;  conditional E-value: 4.5e-05
                 SS--EEE--SS---E-S-...HH..H.-TT--EEE-.-S-----G CS
       LRR_4   1 pnLevLdLsnNqltdipl...le..k.lpnLkeLdLsgNnlitdl 39 
                 +nL++Ld  nN +  i++   l   k + +L +L+L gN   + +
  EFC39917.1 495 CNLRSLDVENNGIG-IDGvkyLTscKtMSKLAYLNL-GN--SQEI 535
                 69**********99.888666447866*********.77..3333 PP

  == domain 10  score: 13.7 bits;  conditional E-value: 1.7e-05
                 S--EEE--SS---E-S-..HH...H-TT--EEE-.-S- CS
       LRR_4   2 nLevLdLsnNqltdipl..le...klpnLkeLdLsgNn 34 
                 nL +L + +N +t i+   +    +lpnL  L L +Nn
  EFC39917.1 558 NLVSLFCCGNTITAISAqyIVsksGLPNLSILVLYDNN 595
                 8999*************76225656*********8884 PP

  == domain 11  score: -2.1 bits;  conditional E-value: 1.7
                 E--SS---E-S CS
       LRR_4   7 dLsnNqltdip 17 
                 d snN +td +
  EFC39917.1 618 DVSNNDMTDYG 628
                 77888888855 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.6   0.0     3e-06     0.011       3      40 ..       6      42 ..       5      46 .. 0.89

  Alignments for each domain:
  == domain 1  score: 15.6 bits;  conditional E-value: 3e-06
  F-box-like  3 rLPdEiLlqIFsyLppsdLlrlalVCrrWrrvaldtpl 40
                +LPd+++  IF +++p++L +    +++++ ++   +l
  EFC39917.1  6 YLPDDVIYSIFTFISPETLKSYVSISSQFYKIITE-RL 42
                7*******************************943.35 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.5   2.7       0.1   3.6e+02      56     149 ..      76     173 ..      69     194 .. 0.65
   2 ?    0.3   0.0      0.12   4.4e+02      79     126 ..     209     256 ..     183     260 .. 0.77
   3 ?    9.3   4.6   0.00021      0.76      48     124 ..     249     330 ..     211     339 .. 0.80
   4 ?    1.5   0.4     0.051   1.8e+02      83     127 ..     412     459 ..     384     482 .. 0.58
   5 ?   -2.0   0.0       0.6   2.2e+03      86     116 ..     468     498 ..     462     511 .. 0.67
   6 ?   11.3   0.9   4.9e-05      0.18      36     141 ..     528     637 ..     515     641 .. 0.78

  Alignments for each domain:
  == domain 1  score: 0.5 bits;  conditional E-value: 0.1
       LRR_9  56 kldgfPllkrlktlllnnnrivria.egleevlPnleelvltnnelqeladldPlaslkkle....llsllknpvtnkkeyrlyviyklkqlrlldfrk 149
                 ++d++  +k++k+l l+ n i     e l   l +l++l l+     +  +l+ l s +kl+    +l l+++++ +     l     l++l+ ld r 
  EFC39917.1  76 RMDEWLIFKKVKMLNLSFNCIDYCHfETLTSRLQSLRHLCLNYVV-LDWQNLNCLLSDEKLTltfeSLELMNCSLNDDMMELLTSCKNLQNLTKLDVRS 173
                 567777888888888888888665437788888888888886654.45566666666665541111456666666655555555556666666666654 PP

  == domain 2  score: 0.3 bits;  conditional E-value: 0.12
       LRR_9  79 iaegleevlPnleelvltnnelqeladl.dPlaslkklellsllknpvt 126
                 i++  +  + +le l++ + e +++ d  +  ++ + +++lsl+++++ 
  EFC39917.1 209 ISQ-TSTLICKLERLLFEDTEYKRIEDYcNACVENNTITSLSLIQCSLK 256
                 543.456789999999999999999985367889999999***999875 PP

  == domain 3  score: 9.3 bits;  conditional E-value: 0.00021
       LRR_9  48 dlsdndirkldgfPllkrl...ktlllnnnrivriaeglee..vlPnleelvltnnelqeladldPlaslkklellsllknp 124
                  l    ++k d +Pll++l   k l l++nr+ +    l++  +l nleel+l +n + + +    + ++++l+l+sll n 
  EFC39917.1 249 SLIQCSLKKYDIIPLLNKLsnlKYLNLSKNRLGQDFLVLNDcfTLRNLEELILESNFIAHETCQLLIDKFENLKLFSLLGNN 330
                 555678999******9985222777888999988777777733589***********976555456789**********986 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.051
       LRR_9  83 leevlPnleelvltnnelqeladldPla...slkklellsllknpvtn 127
                  ++vl nlee+ +++ ++  l  +  l    slkkl+ l ++++++t 
  EFC39917.1 412 TSKVLGNLEEIEVNDCSVITLEMMSSLFkseSLKKLRKLKMFSCSLTG 459
                 456777777777666666555555555312256666666666666655 PP

  == domain 5  score: -2.0 bits;  conditional E-value: 0.6
       LRR_9  86 vlPnleelvltnnelqeladldPlaslkkle 116
                 +l n+++l+l +n++ + +  +  ++  +l+
  EFC39917.1 468 ILRNMSQLILCDNNIGNEGLYNICTNCCNLR 498
                 5678888888888887655444444444444 PP

  == domain 6  score: 11.3 bits;  conditional E-value: 4.9e-05
       LRR_9  36 nlGatld..qfdtidlsdndirkldgfPllkrlktlllnnnrivriaegl...eevlPnleelvltnnelqeladldPlaslkklellsllknpvtnkk 129
                 nlG + +   f  i ++d+ i+ l +  +l+ l +l+   n i+ i+ +    +  lPnl+ lvl +n++ + +      ++++l+   +++ +  + +
  EFC39917.1 528 NLGNSQEiqNFKNI-IDDDCIQLLCSSIYLNNLVSLFCCGNTITAISAQYivsKSGLPNLSILVLYDNNICDRGAEVFSENVESLRHYNIFDVSNNDMT 625
                 77776542168888.888889999999*******************9985333567*************998877555567788888777777777777 PP

       LRR_9 130 eyrlyviyklkq 141
                 +y   ++  + q
  EFC39917.1 626 DYGVNLMSNISQ 637
                 777666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (650 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       752  (0.0419432); expected 358.6 (0.02)
Passed bias filter:                      358  (0.0199677); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.76u 0.30s 00:00:01.06 Elapsed: 00:00:00.54
# Mc/sec: 3639.99
//
Query:       EFC39918.1  [L=1434]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.5e-14   54.2   0.2    5.2e-14   52.4   0.2    2.0  1  G8            G8 domain
    3.5e-11   43.3  60.6    1.3e-05   25.4   6.4    4.9  4  EGF_2         EGF-like domain
     0.0022   18.2   2.2     0.0022   18.2   2.2    5.2  5  EGF           EGF-like domain
  ------ inclusion threshold ------
      0.016   15.2   1.3      0.016   15.2   1.3    3.5  4  EGF_Tenascin  Tenascin EGF domain
        0.1   13.5   0.0       0.22   12.5   0.0    1.6  1  CHRD          CHRD domain
        3.5    7.5  26.4       0.19   11.5  11.7    4.2  3  Beta_helix    Right handed beta helix region


Domain annotation for each model (and alignments):
>> G8  G8 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   52.4   0.2   1.7e-17   5.2e-14      13     123 .]      49     166 ..      43     166 .. 0.87

  Alignments for each domain:
  == domain 1  score: 52.4 bits;  conditional E-value: 1.7e-17
          G8  13 nvvIpagktvlldvsspk.lrsllve..GtLifsddksdielnaeyilvqggGkleiGteeepfkgkatItLyG......teewsstelpdlgaKvlav 102
                 n +I+ +++ lld+s+   l  ++v+   +Lif ++  +++l  + i v +gGkl++G++++p++gk+ +t+yG          ++ ++++ gaK+la+
  EFC39918.1  49 NSTITISQNTLLDKSPGVlLYGIIVQqnASLIF-NN-VNLNLTLQFIRVDKGGKLIAGSSSCPITGKIVVTFYGnrtasnIIGIDPFDGSSGGAKGLAA 145
                 5678889999***6665548999999*******.77.8************************************76654444445556899999***** PP

          G8 103 sngGtlelhGqprkktwtkLa 123
                 ++g  ++++G+    +w +La
  EFC39918.1 146 MSGSFIQIVGSVDGLSWVELA 166
                 *****************9996 PP

>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.9  14.9   3.6e-05      0.11       1      32 []    1292    1319 ..    1292    1319 .. 0.94
   2 !   11.2  11.2   0.00012      0.36       1      32 []    1324    1351 ..    1324    1351 .. 0.86
   3 !   11.3   4.2   0.00011      0.34       5      32 .]    1363    1389 ..    1357    1389 .. 0.93
   4 !   25.4   6.4   4.4e-09   1.3e-05       6      32 .]    1405    1430 ..    1401    1430 .. 0.90

  Alignments for each domain:
  == domain 1  score: 12.9 bits;  conditional E-value: 3.6e-05
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  C +s   C+g+G C ++   C+C++g+ G tC
  EFC39918.1 1292 CAQS---CNGNGNCTAPF-TCQCNQGWIGETC 1319
                  8887...*******9888.8************ PP

  == domain 2  score: 11.2 bits;  conditional E-value: 0.00012
       EGF_2    1 CsasdeiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  Cs +   C ++G+C+++   C C+sgy   +C
  EFC39918.1 1324 CSLN---CTNRGQCISPD-TCLCNSGYGATQC 1351
                  8766...********999.9******966666 PP

  == domain 3  score: 11.3 bits;  conditional E-value: 0.00011
       EGF_2    5 deiCgghGtCvnqcGqCdCdsgyqGktC 32  
                  ++ C+g G C ++   C C+ g+ G+ C
  EFC39918.1 1363 GLVCSGVGNCTSPD-TCACPLGRIGNEC 1389
                  678********999.9***********9 PP

  == domain 4  score: 25.4 bits;  conditional E-value: 4.4e-09
       EGF_2    6 eiCgghGtCvnqc.GqCdCdsgyqGktC 32  
                  + C+ hG+C+  + G+C+C+ g+ G +C
  EFC39918.1 1405 LVCSKHGICI--TdGKCSCNEGWKGTKC 1430
                  57*******9..559************* PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -7.6   4.7         6   1.8e+04       1       7 [.     892     898 ..     892     898 .. 0.87
   2 !    6.3   9.0    0.0039        12       6      32 .]    1296    1318 ..    1290    1318 .. 0.86
   3 ?    3.4  11.6     0.032        96       1      28 [.    1324    1346 ..    1319    1347 .. 0.91
   4 ?    3.9   3.1     0.023        68       6      31 ..    1366    1387 ..    1362    1388 .. 0.86
   5 !   18.2   2.2   7.5e-07    0.0022       3      30 ..    1402    1427 ..    1401    1429 .. 0.90

  Alignments for each domain:
  == domain 1  score: -7.6 bits;  conditional E-value: 6
                 GCSTTST CS
         EGF   1 CspnpCs 7  
                 C+ n+C+
  EFC39918.1 892 CPNNNCQ 898
                 99999*7 PP

  == domain 2  score: 6.3 bits;  conditional E-value: 0.0039
                  STTT-EEEEETTTEEEEEECTTEESTT CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGkr 32  
                  C+++G C       +tC+C +G+ G++
  EFC39918.1 1296 CNGNGNC----TAPFTCQCNQGWIGET 1318
                  *******....6789**********86 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.032
                  GCSTTSTTT-EEEEETTTEEEEEECTTE CS
         EGF    1 CspnpCsngGtCvdtgrggytCiCpeGy 28  
                  Cs  +C n+G C+++     tC C +Gy
  EFC39918.1 1324 CS-LNCTNRGQCISPD----TCLCNSGY 1346
                  66.68***********....*******9 PP

  == domain 4  score: 3.9 bits;  conditional E-value: 0.023
                  STTT-EEEEETTTEEEEEECTTEEST CS
         EGF    6 CsngGtCvdtgrggytCiCpeGytGk 31  
                  Cs+ G C ++     tC Cp G  G+
  EFC39918.1 1366 CSGVGNCTSPD----TCACPLGRIGN 1387
                  99999997777....*******9996 PP

  == domain 5  score: 18.2 bits;  conditional E-value: 7.5e-07
                  STT..STTT-EEEEETTTEEEEEECTTEES CS
         EGF    3 pnp..CsngGtCvdtgrggytCiCpeGytG 30  
                  +np  Cs++G+C++ g    +C C eG++G
  EFC39918.1 1402 SNPlvCSKHGICITDG----KCSCNEGWKG 1427
                  79999*******7777....********99 PP

>> EGF_Tenascin  Tenascin EGF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -4.4   2.8         6   1.8e+04       1      28 [.    1291    1319 ..    1291    1320 .. 0.74
   2 ?    7.8   8.0    0.0012       3.6       2      29 .]    1324    1352 ..    1323    1352 .. 0.91
   3 ?   -6.2   3.8         6   1.8e+04       6      19 ..    1366    1380 ..    1364    1389 .. 0.53
   4 ?   15.2   1.3   5.4e-06     0.016       3      28 ..    1404    1430 ..    1403    1431 .. 0.92

  Alignments for each domain:
  == domain 1  score: -4.4 bits;  conditional E-value: 6
  EGF_Tenascin    1 YCPLGCssRGvCvDG.qCiCDsEYsGDDC 28  
                    +C   C   G C     C C+  + G+ C
    EFC39918.1 1291 FCAQSCNGNGNCTAPfTCQCNQGWIGETC 1319
                    57778889999975426888888888877 PP

  == domain 2  score: 7.8 bits;  conditional E-value: 0.0012
  EGF_Tenascin    2 CPLGCssRGvCvD.GqCiCDsEYsGDDCs 29  
                    C L C  RG C+    C+C+s Y    Cs
    EFC39918.1 1324 CSLNCTNRGQCISpDTCLCNSGYGATQCS 1352
                    99**********7357********99998 PP

  == domain 3  score: -6.2 bits;  conditional E-value: 6
  EGF_Tenascin    6 CssRGvCvD.GqCiC 19  
                    Cs  G C     C C
    EFC39918.1 1366 CSGVGNCTSpDTCAC 1380
                    666666653123444 PP

  == domain 4  score: 15.2 bits;  conditional E-value: 5.4e-06
  EGF_Tenascin    3 PLGCssRGvCv.DGqCiCDsEYsGDDC 28  
                    PL Cs  G+C+ DG+C C+  + G  C
    EFC39918.1 1404 PLVCSKHGICItDGKCSCNEGWKGTKC 1430
                    9*********87*******99999988 PP

>> CHRD  CHRD domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.0   7.4e-05      0.22       5     116 .]     925    1033 ..     921    1033 .. 0.76

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.4e-05
        CHRD    5 LsgaqevppavttgasGtavltldddgktlsysvtvsglsdvtaaHiheg...aagengpvvvtleetekekesaetvpgaatlteeqlaalkagel 98  
                  L++ q+ +   ++g+ G + + l  +++t+ ++v+   l     +H+ +      g+ g++v  l e++   ++ ++++++ +++ ++  +l++ge+
  EFC39918.1  925 LQPCQVSSSMINAGGNGKVLAGLLANKRTVDFTVYHD-L-----SHLATQiqvGIGKIGEIVRFLQEPSIYPSPYSVSRFSMDFSYDEIISLLKGEV 1015
                  5566644466777888888888867788888877653.5.....34333344447899999999999988888777777999999899999****** PP

        CHRD   99 yvnvhteefpgGeiRGql 116 
                  +v + t ++p+G +R ql
  EFC39918.1 1016 FVLLRTSTNPNGHLRAQL 1033
                  ****************97 PP

>> Beta_helix  Right handed beta helix region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.2   0.3     0.096   2.9e+02     100     155 ..      49      83 ..      27     136 .. 0.62
   2 ?   11.5  11.7   6.5e-05      0.19      13     122 ..     327     474 ..     318     484 .. 0.68
   3 ?    1.3   1.5     0.091   2.7e+02      11      90 ..     529     609 ..     510     693 .. 0.56

  Alignments for each domain:
  == domain 1  score: 1.2 bits;  conditional E-value: 0.096
                 -S--EEES-EEESTT....--SEE---TT---EEES-EEES-SSEEEE-TT-SS--EEES CS
  Beta_helix 100 ssnntienNiidnna....gsGividdsssnvtvtnNtitnnkgaGiavvgsssnvtvrn 155
                 +s +ti+ N++ + +     +Gi +++++                        s + ++n
  EFC39918.1  49 NSTITISQNTLLDKSpgvlLYGIIVQQNA------------------------S-LIFNN 83 
                 33344444444444433333333333333........................3.22222 PP

  == domain 2  score: 11.5 bits;  conditional E-value: 6.5e-05
                 EESEEEES-SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT..-S-EEES-EE................E---SEEE-TT--S--EEES-EEES-SS- CS
  Beta_helix  13 iknntisnsggyGiylrgssnvvienneiannsgsGiyilgs..snntisnnti................sdnngggialfgasnnlienneitdnggs 93 
                 +k+n i+ns++ +i++ +s+ + ienn+++n +g+ + ++++   +n ++nn                  +dn  + +    +  n +e+n+ +  +  
  EFC39918.1 327 LKDNSIYNSYQRCITVHDSNYIQIENNVCYNINGHAFFLENGseMYNLFKNNLGakvlpiidsdplqiipTDND-VSVFWITNAMNYFEGNRAIGGKF- 423
                 67888888888888888888888888888888888888887777777777777766666777666666666666.55655566668888888888855. PP

                 SEE-TT............-S-..........-EEES-EEESTT--SEE--- CS
  Beta_helix  94 Giylny............ssn..........ntienNiidnnagsGividd 122
                 G++++             ++            +++nN++++ ++ G++idd
  EFC39918.1 424 GYWFSLpeyaiglvqdkyANTtlirprmlplGSFKNNVVHSANHVGLHIDD 474
                 666665566666655554222334444444455588888888888888876 PP

  == domain 3  score: 1.3 bits;  conditional E-value: 0.091
                 .EEESEEEES-SS-SEEE-SSS-.EEES-EEES-SS-SEEE-TT-S-EEES-EE...E---SEEE-TT.--S--EEES-EEES- CS
  Beta_helix  11 vtiknntisnsggyGiylrgssnvvienneiannsgsGiyilgssnntisnnti...sdnngggialf.gasnnlienneitdn 90 
                 +t++n+ + + ++ Gi + g  + v+e+++++    ++++ ++ +++ +s+++    s+  ++ ++ f ++++    +n++++n
  EFC39918.1 529 ITLRNMFVGD-SRIGIDVAGEPS-VVEDSVFEA-ESDNVGETYRAGIDVSRSYPgffSNTEEFKAYEFyDNGGPSYVRNTVFRN 609
                 4666666666.688888888888.888888888.44444444444444444443222222222222222333444444444444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1434 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       449  (0.0250432); expected 358.6 (0.02)
Passed bias filter:                      248  (0.0138323); expected 358.6 (0.02)
Passed Vit filter:                        32  (0.00178482); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.92u 0.32s 00:00:01.24 Elapsed: 00:00:00.58
# Mc/sec: 7455.71
//
Query:       EFC39919.1  [L=546]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (546 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1202  (0.0670422); expected 358.6 (0.02)
Passed bias filter:                      360  (0.0200792); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         8  (0.000446204); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.83u 0.36s 00:00:01.19 Elapsed: 00:00:00.56
# Mc/sec: 2913.49
//
Query:       EFC39920.1  [L=397]
Description: A20-like zinc finger domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.2e-07   31.6  12.0    2.1e-07   30.8  12.0    1.4  1  zf-A20      A20-like zinc finger
    2.8e-05   23.9   0.0    5.4e-05   23.0   0.0    1.4  1  F-box-like  F-box-like
     0.0011   18.5   0.9      0.087   12.3   0.3    2.3  2  PRORP       Protein-only RNase P
  ------ inclusion threshold ------
      0.018   15.6   2.8       0.16   12.5   2.9    2.4  3  DUF16       Protein of unknown function DUF16
      0.018   14.9   0.0      0.031   14.2   0.0    1.5  1  F-box       F-box domain
       0.11   13.2   1.2       0.32   11.7   1.2    1.7  1  Fmp27_SW    RNA pol II promoter Fmp27 protein domain
       0.15   12.2   0.6       0.38   10.9   0.1    1.9  2  Holin_SPP1  SPP1 phage holin
       0.24   11.1   0.5       0.42   10.3   0.5    1.3  1  EMC3_TMCO1  Integral membrane protein EMC3/TMCO1-like
        1.2    9.3   4.5       0.98    9.5   0.8    2.4  3  ArfGap      Putative GTPase activating protein for Arf


Domain annotation for each model (and alignments):
>> zf-A20  A20-like zinc finger
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   30.8  12.0     1e-10   2.1e-07       3      24 .]       4      25 ..       3      25 .. 0.99

  Alignments for each domain:
  == domain 1  score: 30.8 bits;  conditional E-value: 1e-10
      zf-A20  3 CrngCGFyGnpatnglCSkCYk 24
                Cr+gCGF+G+ a++g+CS C+k
  EFC39920.1  4 CRGGCGFFGSEANKGYCSQCFK 25
                *********************8 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   23.0   0.0   2.7e-08   5.4e-05       8      47 ..     101     139 ..      98     140 .. 0.88

  Alignments for each domain:
  == domain 1  score: 23.0 bits;  conditional E-value: 2.7e-08
  F-box-like   8 iLlqIFsyLppsdLlrlalVCrrWrrvaldtplLWrrlvl 47 
                 i ++I +yL psd +    +C++++ +a+ + ++W++l++
  EFC39920.1 101 IFSHISQYLTPSDVSKFGTTCKSFNKIASEE-SVWKNLYI 139
                 44566679********************988.******98 PP

>> PRORP  Protein-only RNase P
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.3   0.3   4.4e-05     0.087       3      60 ..      16      73 ..      15     118 .. 0.82
   2 ?    4.4   0.0     0.011        23     127     148 ..     241     263 ..     233     275 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.3 bits;  conditional E-value: 4.4e-05
       PRORP  3 ksGkCssCkekLesidlseeefeelresllkkvleredkfkkttPeelerfqkfvekt 60
                ++G Cs+C +kL s +++ ++f++ ++   +kv + e++  k   eel + +++ + +
  EFC39920.1 16 NKGYCSQCFKKLPSDQVTTDDFDQWKKAHEEKVKKIEEENTKKRLEELAKQEEYENPR 73
                68*********************************9999999999***9999987655 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.011
       PRORP 127 keaaalfltdnlseDD.pflLYA 148
                 ++ ++l++t + seD+ ++lLY 
  EFC39920.1 241 EKVKSLYVTREKSEDEtWYLLYI 263
                 56789**********84689995 PP

>> DUF16  Protein of unknown function DUF16
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   2.9     8e-05      0.16       4      55 ..      18      68 ..      15      85 .. 0.78
   2 ?   -1.6   0.0       1.9   3.9e+03      57      75 ..     236     254 ..     229     273 .. 0.69
   3 ?   -1.5   0.0       1.8   3.5e+03      84     104 .]     298     318 ..     278     318 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 8e-05
                XXXXXXXXX.X.XTTB-BHHHHHHB-..BHHHHHHHHHHHH....HHHHHHHH CS
       DUF16  4 GsfneivKkiPvkteYVTrkqlnefkdsnkqrLkkieakvd.klgeqinkleq 55
                G   + +Kk+P  ++ VT  +++++k+  ++++kkie++ + k+ e+++k+e+
  EFC39920.1 18 GYCSQCFKKLP--SDQVTTDDFDQWKKAHEEKVKKIEEENTkKRLEELAKQEE 68
                7778899**99..778********************98654145566666554 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 1.9
                 HHHHHHHHHHHHHHHHHHH CS
       DUF16  57 vekqgekikelkveqkaqg 75 
                 +e + ek+k l v+ ++ +
  EFC39920.1 236 IELLVEKVKSLYVTREKSE 254
                 5566666666666665554 PP

  == domain 3  score: -1.5 bits;  conditional E-value: 1.8
                 HHHHHHHHHHHHHHHHHHHC- CS
       DUF16  84 tleliletLqkinkRlDsieg 104
                  +  + + L++++ RlDs e+
  EFC39920.1 298 KFYTVNNGLTTFGIRLDSWES 318
                 5567888999999****9885 PP

>> F-box  F-box domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   14.2   0.0   1.6e-05     0.031      10      45 ..     101     136 ..      23     139 .. 0.80

  Alignments for each domain:
  == domain 1  score: 14.2 bits;  conditional E-value: 1.6e-05
                 HHHHHHHTS-HHHHHHHCTT-HHHHHHHTTHHHHHH CS
       F-box  10 vlrhILerLplsdllalrrVSkgwrilidsdrlwck 45 
                 +  hI ++L +sd+  +  ++k+++++  + + w+ 
  EFC39920.1 101 IFSHISQYLTPSDVSKFGTTCKSFNKIASEESVWKN 136
                 678*************************99999986 PP

>> Fmp27_SW  RNA pol II promoter Fmp27 protein domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.7   1.2   0.00016      0.32      11      63 ..      38      90 ..      32     109 .. 0.85

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00016
    Fmp27_SW 11 ksWirri.kaakekqkeeikeirerlygkeelskedkdknekilplpkrppLlr 63
                 +W++ + +++k+ ++e+ k++ e+l ++ee+ + +++k + i++ +k ppL++
  EFC39920.1 38 DQWKKAHeEKVKKIEEENTKKRLEELAKQEEYEN-PRKKRKPIVEEKKWPPLTS 90
                58*****89999999999************9755.5555566*********986 PP

>> Holin_SPP1  SPP1 phage holin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.9   0.1   0.00019      0.38      53      69 ..     132     148 ..     112     151 .. 0.86
   2 ?   -3.0   0.0       4.4   8.7e+03      18      28 ..     302     312 ..     301     315 .. 0.86

  Alignments for each domain:
  == domain 1  score: 10.9 bits;  conditional E-value: 0.00019
  Holin_SPP1  53 awyKNnyvTkkakkqke 69 
                 +++KN y+Tk++k++ +
  EFC39920.1 132 SVWKNLYITKYGKQALQ 148
                 79***********9865 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 4.4
  Holin_SPP1  18 lnqlltilGkn 28 
                 +n  lt++G++
  EFC39920.1 302 VNNGLTTFGIR 312
                 79999999985 PP

>> EMC3_TMCO1  Integral membrane protein EMC3/TMCO1-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.5   0.00021      0.42      27      83 ..      17      73 ..      13     112 .. 0.85

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 0.00021
  EMC3_TMCO1 27 tgllsellqkllidkkkmekeqkrekelqkrarelqkngdklklkklekrqeelmed 83
                +g+ s+  +kl+ d+ +++ + + +k++++++++ ++++ k++l++l+k++e+ +  
  EFC39920.1 17 KGYCSQCFKKLPSDQVTTDDFDQWKKAHEEKVKKIEEENTKKRLEELAKQEEYENPR 73
                68999999****************************************999886555 PP

>> ArfGap  Putative GTPase activating protein for Arf
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.5   0.8   0.00049      0.98      39      97 ..      20      76 ..      18      85 .. 0.83
   2 ?    0.2   0.1      0.39   7.8e+02      59      94 ..     140     172 ..     119     189 .. 0.61
   3 ?   -3.5   0.0       5.2     1e+04      51      83 ..     241     274 ..     238     283 .. 0.56

  Alignments for each domain:
  == domain 1  score: 9.5 bits;  conditional E-value: 0.00049
                HHHHHCCS.TTT--EEETTTS---HHHHHHHHHTCHHHHHHHHTTTC-TTTSG-TTCGH CS
      ArfGap 39 CsgvHrslgvhiskvrsltldkwedeelellkalgNkkaneileaklpkeekrsksssk 97
                Cs ++++l     +v   + d+w++++ e +k++ ++++++ le+  ++ee++++++++
  EFC39920.1 20 CSQCFKKL--PSDQVTTDDFDQWKKAHEEKVKKIEEENTKKRLEELAKQEEYENPRKKR 76
                99999999..688999999**************************99999888444333 PP

  == domain 2  score: 0.2 bits;  conditional E-value: 0.39
                 S---HHHHHHHHHTCHHHHHHHHTTTC-TTTSG-TT CS
      ArfGap  59 dkwedeelellkalgNkkaneileaklpkeekrsks 94 
                 +k+ ++ l+++  +g+k ++++++ + ++ ++  ++
  EFC39920.1 140 TKYGKQALQTF--VGDKSVRSVWQDQAKEISST-SR 172
                 44444444444..79999999999888655544.33 PP

  == domain 3  score: -3.5 bits;  conditional E-value: 5.2
                 --EEETTTS---H.HHHHHHHHTCHHHHHHHHTT CS
      ArfGap  51 skvrsltldkwed.eelellkalgNkkaneilea 83 
                 +kv+sl +++ ++ +e   l  + N+k  e++ a
  EFC39920.1 241 EKVKSLYVTREKSeDETWYLLYILNEKKLEFFSA 274
                 5777777666333033444445566666666655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (397 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1693  (0.094428); expected 358.6 (0.02)
Passed bias filter:                      798  (0.0445089); expected 358.6 (0.02)
Passed Vit filter:                        73  (0.00407162); expected 17.9 (0.001)
Passed Fwd filter:                         9  (0.00050198); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               9  [number of targets reported over threshold]
# CPU time: 0.68u 0.34s 00:00:01.02 Elapsed: 00:00:00.52
# Mc/sec: 2287.72
//
Query:       EFC39921.1  [L=331]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.1e-62  212.1   0.1    1.2e-62  212.0   0.1    1.0  1  PALP        Pyridoxal-phosphate dependent enzyme
  ------ inclusion threshold ------
      0.069   13.1   0.0       0.14   12.1   0.0    1.6  1  ADH_zinc_N  Zinc-binding dehydrogenase


Domain annotation for each model (and alignments):
>> PALP  Pyridoxal-phosphate dependent enzyme
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  212.0   0.1   1.4e-66   1.2e-62       2     292 ..       8     300 ..       7     302 .. 0.91

  Alignments for each domain:
  == domain 1  score: 212.0 bits;  conditional E-value: 1.4e-66
                 GGCSSS--EEEECCTCCCCCCE..EEEEEGGGSTTSBTTHHHHHHHHHHHHTT....TTTSEEEEEBSSHHHHHHHHHHHHHT-EEEEEEETTS-HHHH CS
        PALP   2 tlgigpTPlvrlprlskelgvp..lflKlEslnptgSfKdRgaeyllarlkeg....tgaktvveassGNhgralAaaaallGlkvtivvpadaspekv 94 
                 t  ig+TPl+ l++l++e+g+   + lKlEsl p+ S+KdR a ++++ ++++     g+++++e +sGN+g+++A++aa  G+++ti +p+++s e++
  EFC39921.1   8 TELIGNTPLLYLNKLTAEHGAVakIALKLESLEPMSSVKDRIALSMIEVAEKEgkiqPGKTVLIEPTSGNTGIGIAFIAASKGYECTIIMPDSMSIERR 106
                 7889*****************99**************************77777998899999************************************ PP

                 HHHHHTT-EEEEE..CCHHHHHHHHHHHHHHHSTTCEE--TTTSHHHHHH.HHTHHHHHHHHTTTTEEEEEEE-SSSHHHHHHHHHHHH.....HSTT- CS
        PALP  95 allrllGaevvev..ggdydeavaaaaelaaegegaylvsqfdnptvieg.ygtiglEileqlggkpdavvvpvGgGgliaGiaaglke.....rrpdv 185
                   lr+lGa+++++   ++ + ava+a++la+++e+ +++ qfdnp++ +  y+t+g+Ei+++++gk+d +v ++G+Gg+++G+++++ e     +r +v
  EFC39921.1 107 VVLRSLGAKLILTpaAKGMKGAVAVAEKLAQRTENSFILGQFDNPANPLIhYNTTGPEIYRDTDGKIDIFVSGAGTGGTFSGCMKYFNEqtekeGRAKV 205
                 *************88777***********************************************************************8776666669 PP

                 EEEEEEECTTCGGTTCCS..S.SS..B.SSS.CCSTCS.CGTTCCHHHHSEEEEEEEEEEHHHHHHHHHHHHHHHSB-B-HHHHHHHHHH.HHHHHHCC CS
        PALP 186 rvigvepegsdalarslragrrvtvpvsdtiadglavg.spselafelldrlvdeivtvsdeealeamrllarregivvepssaaalaal.klreagel 282
                 r i+ epe+s+ + +           +s++ ++g+++g  p +l+ +l+d    ei  v ++ a++ +++ a +eg++v+ ss+aa+ a+ + +++ e 
  EFC39921.1 206 RGIVLEPEESAVISGNT---------PSPHKIQGIGAGfIPNTLDTSLID----EIFKVHSDNAVKFAKEAALKEGLFVGISSGAAIYAAlEVAKRPEN 291
                 99999*********999.........89**********988888888885....5566***********************666665555366666666 PP

                 TTCEEEEEEE CS
        PALP 283 kegdrvvvil 292
                 +++  +v+i+
  EFC39921.1 292 EGK-LIVAII 300
                 666.899887 PP

>> ADH_zinc_N  Zinc-binding dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.1   0.0   1.6e-05      0.14       1      54 [.      79     139 ..      79     219 .. 0.77

  Alignments for each domain:
  == domain 1  score: 12.1 bits;  conditional E-value: 1.6e-05
                 HHHHHHHHHHHHTT-EEEE.EESSHHHHHHHHHTTESEEEET.....TTC.HHHHHHHHHT CS
  ADH_zinc_N   1 gvGlaavqlAkalGaevia.vdsseeklelakklGadeviny.....kea.dlverikelt 54 
                 g+G+a +++ k + +++i+  + s e++  +++lGa+ ++++     k a  + e++++ t
  EFC39921.1  79 GIGIAFIAASKGYECTIIMpDSMSIERRVVLRSLGAKLILTPaakgmKGAvAVAEKLAQRT 139
                 8******************55567789999999*********8866655556777777666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (331 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       474  (0.0264376); expected 358.6 (0.02)
Passed bias filter:                      446  (0.0248759); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.60u 0.32s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1923.47
//
Query:       EFC39922.1  [L=452]
Description: ATS1 domain-containing protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    3.5e-20   72.3   0.3     0.0013   19.3   0.0    8.0  7  RCC1      Regulator of chromosome condensation (RCC1) repeat
    6.4e-15   54.5   0.8    0.00027   20.6   0.0    4.9  4  RCC1_2    Regulator of chromosome condensation (RCC1) repeat
  ------ inclusion threshold ------
      0.088   13.3   1.5        9.9    6.7   0.1    2.9  2  FucT_N    Alpha-(1,3)-fucosyltransferase FucT N-terminal doma


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.3   0.0   8.2e-06     0.049       7      33 ..       8      34 ..       7      54 .. 0.82
   2 ?    3.9   0.0     0.014        84      29      50 .]     103     130 ..      85     130 .. 0.72
   3 ?    4.2   0.0     0.011        68       4      20 ..     137     153 ..     134     163 .. 0.85
   4 !   11.6   0.0   5.6e-05      0.33       6      48 ..     209     251 ..     206     253 .. 0.93
   5 !   19.3   0.0   2.2e-07    0.0013       4      50 .]     263     309 ..     261     309 .. 0.76
   6 !    6.4   0.1    0.0023        14      24      49 ..     334     358 ..     312     359 .. 0.64
   7 ?    0.8   0.0      0.13     8e+02       8      49 ..     369     414 ..     366     415 .. 0.56

  Alignments for each domain:
  == domain 1  score: 14.3 bits;  conditional E-value: 8.2e-06
                EE--GGGTTSSSS---EEEEEE-GGGT CS
        RCC1  7 WGrndyGqLGlgttesvlvPtkvegls 33
                +Grn++ qLGl  + s+ +Ptk+++ +
  EFC39922.1  8 FGRNENEQLGLNVRTSKCLPTKLNFKN 34
                9***********9999999****8865 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.014
                 -GGGTTS......-EEEEEEETTEEEEE CS
        RCC1  29 veglsgn......rvvkvacGddhtval 50 
                  e+ s++      +v++va G +h+v+l
  EFC39922.1 103 FENISNDiyilkkNVIDVAIGFSHCVFL 130
                 45555446777779***********986 PP

  == domain 3  score: 4.2 bits;  conditional E-value: 0.011
                 EEEEE--GGGTTSSSS- CS
        RCC1   4 VysWGrndyGqLGlgtt 20 
                 +y++G n + +LG  ++
  EFC39922.1 137 LYGFGTNGNCRLGVSHE 153
                 8************8776 PP

  == domain 4  score: 11.6 bits;  conditional E-value: 5.6e-05
                 EEE--GGGTTSSSS---EEEEEE-GGGTTS..-EEEEEEETTEEE CS
        RCC1   6 sWGrndyGqLGlgttesvlvPtkveglsgn..rvvkvacGddhtv 48 
                  +G++ +G L ++++++v  P+k +++s++   + k++ G++h+ 
  EFC39922.1 209 VFGWSYRGELSTKSDKQV--PRKETFFSERnlTIEKIFTGYSHVY 251
                 69****************..********99*************85 PP

  == domain 5  score: 19.3 bits;  conditional E-value: 2.2e-07
                 EEEEE--GGGTTSSSS-......--EEEEEE-GGGTTS-EEEEEEETTEEEEE CS
        RCC1   4 VysWGrndyGqLGlgtt......esvlvPtkveglsgnrvvkvacGddhtval 50 
                 ++ +G+n+++qLGl +t       +     k+++ +  +++++a G+d+++ l
  EFC39922.1 263 LFVCGWNEDNQLGLTHTnniftiTE----NKLPFVP--DIKDIALGYDFSLIL 309
                 89************99944444322....2445555..9**********9975 PP

  == domain 6  score: 6.4 bits;  conditional E-value: 0.0023
                 EEE..EE-GGGTTS-EEEEEEETTEEEE CS
        RCC1  24 lvP..tkveglsgnrvvkvacGddhtva 49 
                 ++P  +k+++    +v+ +++G++h+++
  EFC39922.1 334 NYPnaKKIKLE---NVSRISAGYYHCIL 358
                 55655566554...8**********986 PP

  == domain 7  score: 0.8 bits;  conditional E-value: 0.13
                 E--GGGTTSSSS---EEEEEE-GGGTTS.......-EEEEEEETTEEEE CS
        RCC1   8 GrndyGqLGlgttesvlvPtkveglsgn.......rvvkvacGddhtva 49 
                 G nd  q+G  +++    P + +g +++       + + va+G++ t+ 
  EFC39922.1 369 GVNDCAQCGFNDDDMI--P-RSPGVNRElviehtaNLSLVAAGQYSTAI 414
                 6677777777776444..3.12222222233345578889999998876 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.5   0.2   4.2e-07    0.0025       1      27 [.     117     144 ..     117     146 .. 0.88
   2 !    5.6   0.0    0.0023        14       2      30 .]     241     273 ..     240     273 .. 0.68
   3 !   20.6   0.0   4.6e-08   0.00027       1      24 [.     296     319 ..     296     320 .. 0.97
   4 !    4.9   0.1    0.0039        23       1      12 [.     346     357 ..     346     363 .. 0.79

  Alignments for each domain:
  == domain 1  score: 17.5 bits;  conditional E-value: 4.2e-07
      RCC1_2   1 VksvsaGdyHscaLted.GeVlcWGsNs 27 
                 V++v++G +H ++Lt + + ++++G N+
  EFC39922.1 117 VIDVAIGFSHCVFLTKNeNMLYGFGTNG 144
                 89*************76377*****996 PP

  == domain 2  score: 5.6 bits;  conditional E-value: 0.0023
      RCC1_2   2 ksvsaGdyH..sca.Lte.dGeVlcWGsNsdGQ 30 
                 +++  G++H  +++  +e + +++ +G+N+d Q
  EFC39922.1 241 EKIFTGYSHvyYLVkTMEmETKLFVCGWNEDNQ 273
                 6677788884444444444455*********98 PP

  == domain 3  score: 20.6 bits;  conditional E-value: 4.6e-08
      RCC1_2   1 VksvsaGdyHscaLtedGeVlcWG 24 
                 +k+++ G+++s++Lt dG+V+ +G
  EFC39922.1 296 IKDIALGYDFSLILTKDGTVYVFG 319
                 79*********************9 PP

  == domain 4  score: 4.9 bits;  conditional E-value: 0.0039
      RCC1_2   1 VksvsaGdyHsc 12 
                 V  +saG+yH +
  EFC39922.1 346 VSRISAGYYHCI 357
                 567*******65 PP

>> FucT_N  Alpha-(1,3)-fucosyltransferase FucT N-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.1    0.0017       9.9      59      80 ..     104     130 ..      98     137 .. 0.88
   2 ?    4.5   0.2    0.0083        49      14      76 ..     240     305 ..     230     311 .. 0.67

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.0017
      FucT_N  59 ENitpd.....fnlvDlaigFdklkfe 80 
                 ENi +d     +n++D+aigF +  f 
  EFC39922.1 104 ENISNDiyilkKNVIDVAIGFSHCVFL 130
                 999999999999**********99876 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.0083
      FucT_N  14 nellveilsqrfklels.dspdlllysvfge.ealkyekcvkifftgENitpd.fnlvDlaigFdk 76 
                  e++++  s+ + l  + +    l++  ++e ++l   ++ +if ++EN  p   ++ D+a+g+d 
  EFC39922.1 240 IEKIFTGYSHVYYLVKTmEMETKLFVCGWNEdNQLGLTHTNNIFTITENKLPFvPDIKDIALGYDF 305
                 5555555555555544423333345555666577888999*********88863478899999996 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (452 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       471  (0.0262703); expected 358.6 (0.02)
Passed bias filter:                      346  (0.0192983); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.31s 00:00:00.95 Elapsed: 00:00:00.53
# Mc/sec: 2564.55
//
Query:       EFC39923.1  [L=508]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model       Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
    2.5e-79  266.8   0.0    3.2e-79  266.5   0.0    1.1  1  Aminotran_3  Aminotransferase class-III


Domain annotation for each model (and alignments):
>> Aminotran_3  Aminotransferase class-III
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  266.5   0.0   1.8e-83   3.2e-79      10     406 .]      71     496 ..      63     496 .. 0.85

  Alignments for each domain:
  == domain 1  score: 266.5 bits;  conditional E-value: 1.8e-83
                  CEEEEEEEBTEEEETTS-EEEESSHHHHTTTT-BT-HHHHHHHHHHHTT-S--.-TTTCEEHHHHHHHHHHHHHCT-.....SEEEEESSHHHHHHHH CS
  Aminotran_3  10 llvitkaeGvyltdvdgkrylDlvssiavvnlGhahPkvvkavkeqaaklshv.sfgaltnepalklaekllklapk...gldkvflansGseAvetA 103
                   +v +ka+ +y++dv++ +ylD++++     +Gh  +++++++ +q++++++  ++ ++++++a+k+aekl++++ +   ++++v +   GseAve++
   EFC39923.1  71 SIVFQKAKDSYYWDVNNVQYLDMIGGLHTCHIGHGREEMAQVAYNQMKTMEFApNIYNYSHSSAIKCAEKLVSITKHeypSMERVYFTSGGSEAVEAS 168
                  4999***********************************************98356788999*********777765222589*************** PP

                  HHHHHHH.HHHTSHCTT-EEEEETTT---SSHHHHHHSS--TTTTTTCTTB.......-TSEEEE-TTBGGGTB-HH........HHHHHHHHHHHHH CS
  Aminotran_3 104 lKlarky.arekkatektkiiafkgafHGrtlgalsvtgskkkyktlfgpf.......lpevvrlkypdeevlkene........eeeaalleeleal 185
                  + la +y +  ++++ k+kii+f++++HG t+ + s+ ++  k + +++++       + + ++l  + +    +n         ++   ++e+le+l
   EFC39923.1 169 IHLAERYwSLLNNSQTKKKIISFRNCYHGSTFVSSSLNEQVGKDEYGYQNLkgptdrfSKDSIFLSIDFPHDFIVNSfqkhtqhaNNGFFIAEQLENL 266
                  ****876155666999******************998776554444444443333777666666665555444444455555543344468999**** PP

                  H.CHTCCCEEEEEE-SCETTTTSEB--CCHHHHHHHHHHHHT-EEEEE-TTTTTTTTSSSSGGGGCTS--SEEEE-GGGGTT.SS-EEEEEEHHHHTT CS
  Aminotran_3 186 e.kkkkdevaAvivEpiqgegGvvvaspeflaklrelckkhdvllivDEvqtGfGrTGklfAlehagvspDlmtlaKaltgG.lplsavlataevmqa 281
                  +  +  +++aA+i Epiqg  G   + ++f+  +r +c+k++vlli+DEv+tGfG TGk+f+l h+g++pD+++++K++t+G lpl  ++  + + q+
   EFC39923.1 267 IkLEGPENIAAFIAEPIQGVNGALEPHKDFFPLARRICDKYGVLLIADEVMTGFGKTGKWFGLSHYGIEPDIVVFGKGVTSGyLPLGGMMLARHLCQV 364
                  96677899****************************************************************************************** PP

                  S-TTS......B--TTTT-HHHHHHHHHHHHHHHHTTHHHHHHHHHHHHHHHHHHHCTT-TTEEEEEEETTEEEEEEBCCCETTCHHHHHHHHH.CTE CS
  Aminotran_3 282 lapgs......hgsTfgGnplacavalavleiieeekllenaqelgaalkegLeelqkkyevikevRgkGlmiaielkeeaevkekeilkkake.kGv 372
                  l + +      h  Tf+G p+ c ++++ lei+ +e+l+++a+ +g +lk+ L +  +   ++kev g+G+m+++ + e++ +k  +i +++ +   +
   EFC39923.1 365 LFKANiehpflHEFTFSGHPVCCEIVMKNLEIMFDENLVQRAAVMGTQLKSTLVQRLQGIPHFKEVSGMGFMLGLIFDEHVSAK--RIHEELATcYHI 460
                  9999899*********************************************988777778**************888888866..455444431334 PP

                  E-EEETT..TEEEE---TT--HHHHHHHHHHHHHHH CS
  Aminotran_3 373 lilsaGd..nvirllppliitdeeidelleilkkal 406
                  l+  + +  +v+ ++pp+ i++ +++ +++++++++
   EFC39923.1 461 LVDYSRQndRVVLITPPFNIHERDLNIFVDSIEQCV 496
                  4444333459**********************9985 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (508 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       515  (0.0287244); expected 358.6 (0.02)
Passed bias filter:                      402  (0.0224218); expected 358.6 (0.02)
Passed Vit filter:                        23  (0.00128284); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.64u 0.30s 00:00:00.94 Elapsed: 00:00:00.50
# Mc/sec: 3026.67
//
Query:       EFC39924.1  [L=313]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.4e-20   72.8   0.0    1.3e-17   63.9   0.0    2.1  2  adh_short      short chain dehydrogenase
    9.7e-10   38.4   0.0    3.8e-09   36.5   0.0    1.8  2  adh_short_C2   Enoyl-(Acyl carrier protein) reductase
    3.8e-08   33.5   0.0      5e-08   33.1   0.0    1.1  1  KR             KR domain
  ------ inclusion threshold ------
      0.014   14.9   0.0      0.038   13.4   0.0    1.7  2  Epimerase      NAD dependent epimerase/dehydratase family
       0.16   11.3   0.0       0.34   10.3   0.0    1.5  2  GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase


Domain annotation for each model (and alignments):
>> adh_short  short chain dehydrogenase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   63.9   0.0   3.6e-21   1.3e-17       2     138 ..       7     151 ..       6     160 .. 0.88
   2 !    7.0   0.0   0.00097       3.5     147     189 ..     183     231 ..     176     236 .. 0.86

  Alignments for each domain:
  == domain 1  score: 63.9 bits;  conditional E-value: 3.6e-21
                 EEEEESTTSHHHHHHHHHHHHT...T-EEEEEESCHHHHHHHHHHHHHT....TSEEEEEE-TTTSHHHHHHHHHHH.HHHHSSESEEEE---SS--SS CS
   adh_short   2 vvlvtGassGIGraiakelake...Gakvvvvdrseekleevakelkee....gakalaiqvDvtdreevealveka.vkklgkldvLvnNAGitgsgp 92 
                 +v+vtGa  G+G +  k l+++    ++vv++ r e+k +++++++ e     ++++++i++D++d ++v+++v +  ++kl +l +L+ NA+  +  p
  EFC39924.1   7 TVIVTGANCGLGFESTKYLLSDkidEWHVVLACRDESKGKQAIQQIVEIdqeyASRLTFIELDLADLDSVRNFVTNFnQEKLPPLKALICNAAT-QAPP 104
                 89******************96333689****************998886667788*****************998725678***********9.5677 PP

                 GGGCSHHHHHHHHHHHTHHHHHHHHHHHHHHH.HCTTEEEEEEEEGG CS
   adh_short  93 fselseeewervievNltgvflltravlpaml.kqssGrIvnvsSva 138
                   +++++ ++ v+ vN  g fllt +++p++  + +  +Ivnv+S +
  EFC39924.1 105 NISTTKQGYDIVFGVNHLGHFLLTNLLIPHFAkNDEINSIVNVTSDT 151
                 77888888**********************996677799******75 PP

  == domain 2  score: 7.0 bits;  conditional E-value: 0.00097
                 HHHHHHHHHHHHHHHHHHHHHGGGT.....EEEEEEEESSBS.SHHHHH CS
   adh_short 147 aaYsAsKaavagltrslakelaptg.....irvnavaPGlvd.Tdmake 189
                 + Y++sK   + +t +l++ l ++       rvn+ +PG++  T +a+ 
  EFC39924.1 183 SRYATSKLCNILFTYELKNRLDKSDefknhFRVNCFNPGFMPeTSLARY 231
                 78*****************99998777888*********9987887765 PP

>> adh_short_C2  Enoyl-(Acyl carrier protein) reductase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   36.5   0.0   1.1e-12   3.8e-09      18     130 ..      32     151 ..      12     157 .. 0.82
   2 ?   -0.9   0.0      0.28   9.9e+02     162     180 ..     211     229 ..     207     243 .. 0.73

  Alignments for each domain:
  == domain 1  score: 36.5 bits;  conditional E-value: 1.1e-12
                   T-EEEEEESSGGH.HHHHHHHHHHTT...SEE..EE--TTSHHHHHHHHHHHH.HHHSSEEEEEE-----EGCSS-GGGH-HHHHHHHHHHHTHHHH CS
  adh_short_C2  18 Gaevvltdlneea.kkrveelaeelg...aev..lecDVtdeeqvealveevv.ekfgklDilvnnagiapklkgpfletsreefdraldvnlyslf 107
                    ++vvl+ ++e++ k+++++++e  +   +++  +e+D +d ++v+++v +   ek+  l  l+ na+   +   p ++t+++++d ++ vn  + f
    EFC39924.1  32 EWHVVLACRDESKgKQAIQQIVEIDQeyaSRLtfIELDLADLDSVRNFVTNFNqEKLPPLKALICNAATQAP---PNISTTKQGYDIVFGVNHLGHF 125
                   5789*******99999998887743322144257**************998861567*************99...889******************* PP

                   HHHHHHHHHCTSC...CEEEEEEEGG CS
  adh_short_C2 108 llakaalplmkeg...gsivnlssvg 130
                   ll++ ++p+++++    sivn++s  
    EFC39924.1 126 LLTNLLIPHFAKNdeiNSIVNVTSDT 151
                   ********8888879********975 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 0.28
                   GTEEEEEEEE--BHCTGGG CS
  adh_short_C2 162 kgiRvNavspgpikTlaas 180
                   +  RvN+  pg++  ++ +
    EFC39924.1 211 NHFRVNCFNPGFMPETSLA 229
                   578********99655443 PP

>> KR  KR domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   33.1   0.0   1.4e-11     5e-08       2      97 ..       7     106 ..       6     136 .. 0.86

  Alignments for each domain:
  == domain 1  score: 33.1 bits;  conditional E-value: 1.4e-11
                 EEEEETTTSHHHHHHHHHHHHHH..S-EEEEE-SS..--HHHHHHHHHHHHT.T-EEEE----TT-HHHHHHHHHHHHHHS.S---EEEE--------- CS
          KR   2 tylitGGlGgLGlelarwlaekg..arhlvllsRsaaadedskaliaeleal.gaevevvaaDvsdkdavealleeikaee.ppikGvihaAgvlrdkl 96 
                 t+++tG+  gLG e ++ l+++   + h+vl  R++++ +++ ++i e+ +    + +++++D++d d+v++ ++++++e+ pp+k  i  A + +   
  EFC39924.1   7 TVIVTGANCGLGFESTKYLLSDKidEWHVVLACRDESKGKQAIQQIVEIDQEyASRLTFIELDLADLDSVRNFVTNFNQEKlPPLKALICNAATQAPPN 105
                 689****************98776788********99999999999999987577*************************9******999888766555 PP

                 T CS
          KR  97 l 97 
                 +
  EFC39924.1 106 I 106
                 4 PP

>> Epimerase  NAD dependent epimerase/dehydratase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.4   0.0   1.1e-05     0.038       1      63 [.       8      83 ..       8     115 .. 0.79
   2 ?   -1.8   0.0      0.49   1.8e+03     118     150 ..     164     193 ..     162     202 .. 0.69

  Alignments for each domain:
  == domain 1  score: 13.4 bits;  conditional E-value: 1.1e-05
                EEEETTTSHHHHHHHHHHHHCT...SEEEEEES-STTTTCHHCHHC...........EEEE--TT-HHHHHHHHHHH CS
   Epimerase  1 ilVtGatGfiGsalvkallekg...yevigldrlssasntarledl...........elveldltdrsalerlfkee 63
                ++VtGa+  +G   +k+ll+ +   ++v+   r++s++++a ++ +           +++eldl d +++++++ ++
  EFC39924.1  8 VIVTGANCGLGFESTKYLLSDKideWHVVLACRDESKGKQAIQQ-IveidqeyasrlTFIELDLADLDSVRNFVTNF 83
                68********************5443333334444444444433.3599************************9865 PP

  == domain 2  score: -1.8 bits;  conditional E-value: 0.49
                 GGTSCSS..SSBSTCSTTS----SSHHHHHHHHHH CS
   Epimerase 118 vYGkdae..qpkeettltgplkpnspYaaaKlage 150
                 +YG++++  +p +et      k  s Ya +Kl+  
  EFC39924.1 164 TYGPVDKliIPPQETP-----KRDSRYATSKLCNI 193
                 5777777644544444.....78899999999865 PP

>> GDP_Man_Dehyd  GDP-mannose 4,6 dehydratase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.3   0.0   9.5e-05      0.34       2      74 ..      10      83 ..       9      96 .. 0.75
   2 ?   -2.8   0.0      0.87   3.1e+03     133     165 ..     165     197 ..     164     205 .. 0.63

  Alignments for each domain:
  == domain 1  score: 10.3 bits;  conditional E-value: 9.5e-05
                   EETTTSHHHHHHHHHHHHCT.-CCEEEEE.EESS-TTHHHHHCTTT...TTGCCEEEEE--TT-HHHHHHHHHHH CS
  GDP_Man_Dehyd  2 iTGiaGfiGsylaelLlekg.yevhgivr.rsssfntgriehlakdpkeeleenlklhkgDltDssslerllaev 74
                   +TG +   G   +++Ll+ +  e h++   r++s   + i+++ + ++ e+ ++l++++ Dl D +s+++ + + 
     EFC39924.1 10 VTGANCGLGFESTKYLLSDKiDEWHVVLAcRDESKGKQAIQQIVEIDQ-EYASRLTFIELDLADLDSVRNFVTNF 83
                   677776677777888887651445544333666777799999998776.5689***************9998776 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 0.87
                    G-S-SSSSB-TTS-----SHHHHHHHHHHHHHH CS
  GDP_Man_Dehyd 133 YGkvqevpqtEttpfyPrsPYaaaKlyadwivv 165
                    YG v++  +  +   +  s Ya +Kl    ++ 
     EFC39924.1 165 YGPVDKLIIPPQETPKRDSRYATSKLCNILFTY 197
                    666666555544445566788888887666555 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (313 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       502  (0.0279993); expected 358.6 (0.02)
Passed bias filter:                      461  (0.0257125); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.52u 0.24s 00:00:00.76 Elapsed: 00:00:00.44
# Mc/sec: 2159.93
//
Query:       EFC39925.1  [L=118]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.092   13.1   0.1       0.14   12.5   0.1    1.4  1  Ntox44    Bacterial toxin 44


Domain annotation for each model (and alignments):
>> Ntox44  Bacterial toxin 44
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.5   0.1   7.6e-06      0.14      18      73 ..      35      93 ..      24     114 .. 0.75

  Alignments for each domain:
  == domain 1  score: 12.5 bits;  conditional E-value: 7.6e-06
      Ntox44 18 qksklkkiavk.rllk...ssvkdsiykyddlgNihYGyvGraagfseetLlkgaglaqi 73
                +ks++ ++ ++ +  +      ++s +++ +++N+  G +G aa   +++L  g ++ ++
  EFC39925.1 35 AKSWNYTCIIYdAE-EdslCATYQSSMDSAIISNVLAGLTGVAAAAAQSVLTGGFEITAA 93
                55666555555333.23555566679************************9988666554 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (118 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       526  (0.0293379); expected 358.6 (0.02)
Passed bias filter:                      309  (0.0172346); expected 358.6 (0.02)
Passed Vit filter:                        22  (0.00122706); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.39u 0.22s 00:00:00.61 Elapsed: 00:00:00.39
# Mc/sec: 896.64
//
Query:       EFC39926.1  [L=381]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    5.5e-11   42.1  16.0      1e-08   34.8   6.5    5.5  5  LRR_8       Leucine rich repeat
    6.3e-09   36.0  39.3    1.3e-05   25.4   2.6    7.4  5  LRR_4       Leucine Rich repeats (2 copies)
     0.0017   17.9   1.6     0.0017   17.9   1.6    2.7  2  LRR_9       Leucine-rich repeat
  ------ inclusion threshold ------
      0.015   15.2   0.9      0.015   15.2   0.9    1.9  2  F-box-like  F-box-like
      0.024   14.7  22.4       0.33   11.1   0.2    6.5  7  LRR_6       Leucine Rich repeat
        0.9   10.3  29.9        3.4    8.6   0.1    7.2  7  LRR_1       Leucine Rich Repeat


Domain annotation for each model (and alignments):
>> LRR_8  Leucine rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.8   2.1    0.0082        24      11      58 ..      98     144 ..      96     146 .. 0.88
   2 ?   -1.6   0.0      0.82   2.4e+03      45      49 ..     225     229 ..     203     239 .. 0.52
   3 !    5.7   2.2    0.0041        12      20      60 ..     270     315 ..     268     316 .. 0.61
   4 !   34.8   6.5   3.5e-12     1e-08       2      61 .]     305     362 ..     304     362 .. 0.94
   5 !   20.6   2.0   9.6e-08   0.00029       1      32 [.     350     381 .]     350     381 .] 0.97

  Alignments for each domain:
  == domain 1  score: 4.8 bits;  conditional E-value: 0.0082
                 S--SEE-TTSSTT-TT--EEE--SS.---GGGGGGGTT--S-.EEE--S CS
       LRR_8  11 NrltslddeaFkglsnLkvLdLsnN.llttlspgafsgLpsLrsLdLsg 58 
                  rl +l++   ++l+nL++L + n  + + l+   f+  +sL+sL L +
  EFC39926.1  98 KRLANLEQLIVSKLTNLQELIIYNDgSYNLLE--KFMKIESLQSLELHN 144
                 578899999999**********9998888885..***********9975 PP

  == domain 2  score: -1.6 bits;  conditional E-value: 0.82
                 GTT-- CS
       LRR_8  45 fsgLp 49 
                 f++L+
  EFC39926.1 225 FENLT 229
                 33332 PP

  == domain 3  score: 5.7 bits;  conditional E-value: 0.0041
                 SSTT-TT--EEE--..SS---GGGGG...GGTT--S-.EEE--SS- CS
       LRR_8  20 aFkglsnLkvLdLs..nNllttlspg...afsgLpsLrsLdLsgNr 60 
                 +F++++nL+vL+L+  +N  + +  +    f++L +L++LdLs + 
  EFC39926.1 270 FFSNFRNLTVLKLNgcSNDRRDITGNglsNFVNLINLTELDLSFCS 315
                 7888888888888633454444444411156677778888888775 PP

  == domain 4  score: 34.8 bits;  conditional E-value: 3.5e-12
                 T-SEEE-TTS--SEE-TTSSTT-TT--EEE--SS---GGGGGGGTT--S-.EEE--SS-- CS
       LRR_8   2 nLtsLdLsnNrltslddeaFkglsnLkvLdLsnNllttlspgafsgLpsLrsLdLsgNrL 61 
                 nLt+LdLs+ ++++++    +++++L++L+LsnNl++  s + f+ L++L+ L+L++Nr+
  EFC39926.1 305 NLTELDLSFCSIQKVE--YLSSVTSLRILKLSNNLISDESLKDFHKLSNLTALYLDNNRI 362
                 8************996..677779**********************************98 PP

  == domain 5  score: 20.6 bits;  conditional E-value: 9.6e-08
                 TT-SEEE-TTS--SEE-TTSSTT-TT--EEE- CS
       LRR_8   1 pnLtsLdLsnNrltslddeaFkglsnLkvLdL 32 
                 +nLt L+L+nNr+t+l+    + ls+Lk+L+L
  EFC39926.1 350 SNLTALYLDNNRITKLGVNYLSALSSLKILNL 381
                 69*****************************8 PP

>> LRR_4  Leucine Rich repeats (2 copies)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   9.7       3.7   1.1e+04      22      36 ..     111     128 ..      96     248 .. 0.81
   2 ?   -0.3   0.0      0.55   1.6e+03      16      38 ..     243     262 ..     235     269 .. 0.73
   3 !    6.3   1.0    0.0045        13      16      33 ..     268     285 ..     250     300 .. 0.77
   4 !   25.4   2.6   4.4e-09   1.3e-05       2      38 ..     305     340 ..     304     348 .. 0.89
   5 !   18.0   2.7   9.5e-07    0.0028       2      30 ..     351     381 .]     350     381 .] 0.94

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 3.7
                 -TT--EEE-.-S....--- CS
       LRR_4  22 lpnLkeLdLsgN....nli 36 
                 l+nL+eL +  N    nl+
  EFC39926.1 111 LTNLQELII-YNdgsyNLL 128
                 555555544.332222233 PP

  == domain 2  score: -0.3 bits;  conditional E-value: 0.55
                 -S-HHH-TT--EEE-.-S----- CS
       LRR_4  16 iplleklpnLkeLdLsgNnlitd 38 
                 + +l ++ nLk++ + ++  ++d
  EFC39926.1 243 LKFLTSIVNLKKFEC-RC--LWD 262
                 455777889999988.76..655 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0045
                 -S-HHH-TT--EEE-.-S CS
       LRR_4  16 iplleklpnLkeLdLsgN 33 
                 +++++++ nL++L L+g+
  EFC39926.1 268 LEFFSNFRNLTVLKLNGC 285
                 456778*********886 PP

  == domain 4  score: 25.4 bits;  conditional E-value: 4.4e-09
                 S--EEE--SS---E-S-HHH-TT--EEE-.-S----- CS
       LRR_4   2 nLevLdLsnNqltdiplleklpnLkeLdLsgNnlitd 38 
                 nL++LdLs + +++++ l++ ++L+ L L +Nnli+d
  EFC39926.1 305 NLTELDLSFCSIQKVEYLSSVTSLRILKL-SNNLISD 340
                 9****************************.6669966 PP

  == domain 5  score: 18.0 bits;  conditional E-value: 9.5e-07
                 S--EEE--SS---E-S-..HHH-TT--EEE- CS
       LRR_4   2 nLevLdLsnNqltdipl..leklpnLkeLdL 30 
                 nL+ L+L nN++t+++   l+ l +Lk L+L
  EFC39926.1 351 NLTALYLDNNRITKLGVnyLSALSSLKILNL 381
                 9****************98778*******98 PP

>> LRR_9  Leucine-rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.3      0.14   4.1e+02      75     118 ..      99     140 ..      87     148 .. 0.60
   2 !   17.9   1.6   5.6e-07    0.0017      16     118 ..     301     379 ..     295     381 .] 0.50

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 0.14
       LRR_9  75 rivriaegleevlPnleelvltnnelqeladldPlaslkklell 118
                 r+ ++++ +   l nl+el++ n+   +l   + ++++++l++l
  EFC39926.1  99 RLANLEQLIVSKLTNLQELIIYNDGSYNLL--EKFMKIESLQSL 140
                 455555556667788888888775433332..234444444443 PP

  == domain 2  score: 17.9 bits;  conditional E-value: 5.6e-07
       LRR_9  16 inairereldlrgykipvienlGatldqfdtidlsdndir..kldgfPllkrlktlllnnnrivriaegleevlPnleelvltnnelqeladldPlasl 112
                 +n i   eldl    i  +e l  ++  +  ++ls+n i    l +f  l  l +l+l+nnri++++ +   +l +l+                     
  EFC39926.1 301 VNLINLTELDLSFCSIQKVEYLS-SVTSLRILKLSNNLISdeSLKDFHKLSNLTALYLDNNRITKLGVNYLSALSSLK--------------------- 377
                 55555555555555555555554.334455555555555311355555555555555555555555555544444444..................... PP

       LRR_9 113 kklell 118
                     +l
  EFC39926.1 378 ----IL 379
                 ....43 PP

>> F-box-like  F-box-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   15.2   0.9   4.9e-06     0.015       7      33 ..      14      41 ..       7      46 .. 0.79
   2 ?   -3.0   0.1       2.3   6.9e+03      11      24 ..     185     199 ..     184     209 .. 0.61

  Alignments for each domain:
  == domain 1  score: 15.2 bits;  conditional E-value: 4.9e-06
  F-box-like  7 EiLlqIFsyLpps.dLlrlalVCrrWrr 33
                 i  +I+sy +    L++++lVCr+W++
  EFC39926.1 14 VIFFEILSYCDYLwILSSVRLVCRDWNE 41
                47889***9975537888********96 PP

  == domain 2  score: -3.0 bits;  conditional E-value: 2.3
  F-box-like  11 qIFsyLppsdLlr.l 24 
                  I+s ++ s++ + l
  EFC39926.1 185 SILSSMSESSWNSiL 199
                 677777666666544 PP

>> LRR_6  Leucine Rich repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.5   0.0       2.6   7.7e+03       2      10 ..     204     212 ..     204     213 .. 0.85
   2 ?   -0.4   0.2      0.56   1.7e+03       3      13 ..     275     285 ..     275     286 .. 0.87
   3 ?   -1.9   0.1       1.6   4.8e+03       9      16 ..     291     298 ..     291     300 .. 0.57
   4 ?   10.0   0.2   0.00025      0.74       3      16 ..     304     317 ..     302     319 .. 0.87
   5 ?   11.1   0.2   0.00011      0.33       3      21 ..     326     344 ..     326     346 .. 0.91
   6 ?    5.5   0.2    0.0071        21       2      20 ..     349     367 ..     348     371 .. 0.86
   7 ?   -1.6   0.1       1.3   3.8e+03       3      10 ..     374     381 .]     372     381 .] 0.86

  Alignments for each domain:
  == domain 1  score: -2.5 bits;  conditional E-value: 2.6
       LRR_6   2 nthLteLdL 10 
                 + +L+ Ld+
  EFC39926.1 204 CKTLQQLDV 212
                 679****97 PP

  == domain 2  score: -0.4 bits;  conditional E-value: 0.56
       LRR_6   3 thLteLdLsgN 13 
                 ++Lt L L+g+
  EFC39926.1 275 RNLTVLKLNGC 285
                 589*****998 PP

  == domain 3  score: -1.9 bits;  conditional E-value: 1.6
       LRR_6   9 dLsgNdIg 16 
                 d++gN+++
  EFC39926.1 291 DITGNGLS 298
                 56666654 PP

  == domain 4  score: 10.0 bits;  conditional E-value: 0.00025
       LRR_6   3 thLteLdLsgNdIg 16 
                  +LteLdLs++ I+
  EFC39926.1 304 INLTELDLSFCSIQ 317
                 58*********997 PP

  == domain 5  score: 11.1 bits;  conditional E-value: 0.00011
       LRR_6   3 thLteLdLsgNdIgDeGae 21 
                 t+L+ L Ls N I+De ++
  EFC39926.1 326 TSLRILKLSNNLISDESLK 344
                 69**************987 PP

  == domain 6  score: 5.5 bits;  conditional E-value: 0.0071
       LRR_6   2 nthLteLdLsgNdIgDeGa 20 
                  ++Lt+L L  N I+  G+
  EFC39926.1 349 LSNLTALYLDNNRITKLGV 367
                 589************9887 PP

  == domain 7  score: -1.6 bits;  conditional E-value: 1.3
       LRR_6   3 thLteLdL 10 
                 ++L+ L+L
  EFC39926.1 374 SSLKILNL 381
                 79****98 PP

>> LRR_1  Leucine Rich Repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.4      0.85   2.5e+03       1      17 [.     113     139 ..     113     154 .. 0.53
   2 ?   -0.5   0.1       1.1   3.1e+03       2      13 ..     181     200 ..     181     230 .. 0.64
   3 ?    4.6   0.5     0.024        71       1      13 [.     276     290 ..     276     303 .. 0.71
   4 ?    7.6   0.1    0.0023       6.9       1      12 [.     305     316 ..     305     324 .. 0.88
   5 ?    6.4   1.1    0.0057        17       1      23 []     327     349 ..     327     349 .. 0.93
   6 ?    8.6   0.1    0.0011       3.4       1      23 []     351     373 ..     351     373 .. 0.92
   7 ?   -2.6   0.2       5.4   1.6e+04       1       7 [.     375     381 .]     375     381 .] 0.88

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 0.85
       LRR_1   1 nLrhLdL....snnpl......lglpp 17 
                 nL++L +    s+n l      ++l++
  EFC39926.1 113 NLQELIIyndgSYNLLekfmkiESLQS 139
                 667776644444444444444433333 PP

  == domain 2  score: -0.5 bits;  conditional E-value: 1.1
       LRR_1   2 LrhLdL.......snnpl.l 13 
                 L++L +       s+n++ +
  EFC39926.1 181 LEKLSIlssmsesSWNSIlE 200
                 56666666666667777632 PP

  == domain 3  score: 4.6 bits;  conditional E-value: 0.024
       LRR_1   1 nLrhLdLsnnpl..l 13 
                 nL++L L+++++   
  EFC39926.1 276 NLTVLKLNGCSNdrR 290
                 8**********9552 PP

  == domain 4  score: 7.6 bits;  conditional E-value: 0.0023
       LRR_1   1 nLrhLdLsnnpl 12 
                 nL++LdLs +++
  EFC39926.1 305 NLTELDLSFCSI 316
                 8*********98 PP

  == domain 5  score: 6.4 bits;  conditional E-value: 0.0057
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 +Lr L Lsnn +++ +  +f++L
  EFC39926.1 327 SLRILKLSNNLISDESLKDFHKL 349
                 69************999999987 PP

  == domain 6  score: 8.6 bits;  conditional E-value: 0.0011
       LRR_1   1 nLrhLdLsnnpllglppnsfqnL 23 
                 nL+ L+L nn+++ l+ n+++ L
  EFC39926.1 351 NLTALYLDNNRITKLGVNYLSAL 373
                 89***************999865 PP

  == domain 7  score: -2.6 bits;  conditional E-value: 5.4
       LRR_1   1 nLrhLdL 7  
                 +L+ L+L
  EFC39926.1 375 SLKILNL 381
                 69****8 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (381 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       540  (0.0301188); expected 358.6 (0.02)
Passed bias filter:                      292  (0.0162865); expected 358.6 (0.02)
Passed Vit filter:                        29  (0.00161749); expected 17.9 (0.001)
Passed Fwd filter:                         6  (0.000334653); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.58u 0.31s 00:00:00.88 Elapsed: 00:00:00.50
# Mc/sec: 2304.38
//
Query:       EFC39927.1  [L=293]
Description: polyubiquitin [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
     2e-120  392.7  16.4    3.3e-33  113.2   0.7    4.0  4  ubiquitin        Ubiquitin family
    3.3e-57  190.2  16.8    6.7e-16   57.9   0.7    4.0  4  Rad60-SLD        Ubiquitin-2 like Rad60 SUMO-like
    2.3e-20   72.9   9.1    0.00028   21.3   0.2    5.4  4  Ubiquitin_2      Ubiquitin-like domain
    5.4e-17   61.5   0.9      0.015   15.2   0.1    4.2  4  TBK1_ULD         TANK binding kinase 1 ubiquitin-like domain
    2.9e-15   56.4   7.3      0.013   15.8   0.1    4.1  4  Ubiquitin_5      Ubiquitin-like domain
    1.7e-13   50.7   3.4      0.065   13.3   0.0    5.0  4  Rad60-SLD_2      Ubiquitin-2 like Rad60 SUMO-like
    1.9e-12   47.6   1.6      0.035   14.7   0.1    4.1  4  DUF2407          DUF2407 ubiquitin-like domain
    2.1e-08   34.1  20.6        4.7    7.3   0.2    7.9  8  Ubiquitin_4      Ubiquitin-like domain
    2.5e-07   30.7   0.1        0.4   10.5   0.0    3.7  4  Sde2_N_Ubi       Silencing defective 2 N-terminal ubiquitin d
    5.6e-05   23.2   1.0        9.3    6.5   0.0    4.0  4  DUF3861          Domain of Unknown Function with PDB structur
    6.3e-05   23.3   0.3         28    5.2   0.0    4.8  4  DUF2870          Protein of unknown function (DUF2870)
    0.00067   19.8   0.8          2    8.6   0.1    2.8  2  UDP-g_GGTase     UDP-glucose:Glycoprotein Glucosyltransferase
    0.00081   18.8   0.3        1.2    8.4   0.0    2.3  2  Methyltrans_RNA  RNA methyltransferase
     0.0019   18.0   2.8         11    6.0   0.1    3.4  3  ACT_5            ACT domain
     0.0022   18.1   9.2         15    5.8   0.1    4.2  4  ProRS-C_2        Prolyl-tRNA synthetase, C-terminal
     0.0024   18.3   1.6         42    4.7   0.0    4.1  4  UN_NPL4          Nuclear pore localisation protein NPL4
     0.0032   17.5   2.1        1.3    9.0   0.0    3.3  3  DUF218           DUF218 domain
     0.0035   17.4   0.0         37    4.5   0.0    3.6  3  RBD              Raf-like Ras-binding domain
  ------ inclusion threshold ------
      0.011   15.2   0.0         21    4.4   0.0    3.4  4  DUF969           Protein of unknown function (DUF969)
      0.012   15.7   2.7         21    5.4   0.1    3.4  3  YcgR_2           Flagellar protein YcgR
      0.016   15.3   6.8         15    5.9   0.2    3.4  3  Tash_PEST        Tash protein PEST motif
       0.04   14.7   0.0    1.3e+02    3.4   0.0    3.7  4  Big_7            Bacterial Ig domain
      0.071   13.7   0.4    1.2e+02    3.3   0.0    3.4  3  ACT_4            ACT domain
       0.13   12.5   0.0         87    3.4   0.0    3.8  3  ORF11CD3         ORF11CD3 domain
       0.18   12.3   3.6         88    3.7   3.6    3.2  1  Phage_sheath_1N  Phage tail sheath protein beta-sandwich doma
       0.28   10.8   4.4         51    3.5   0.1    3.4  3  HAMP_N3          HAMP N-terminal domain 3
       0.73    9.6   8.4         41    4.0   0.1    4.0  4  PI3K_p85B        PI3-kinase family, p85-binding domain


Domain annotation for each model (and alignments):
>> ubiquitin  Ubiquitin family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   78.2   0.1   4.3e-25   2.8e-22       1      70 [.       3      72 ..       3      74 .. 0.98
   2 !   98.3   0.3   2.4e-31   1.6e-28      10      72 .]      76     138 ..      72     138 .. 0.97
   3 !  113.2   0.7     5e-36   3.3e-33       1      72 []     143     214 ..     143     214 .. 0.99
   4 !  113.2   0.7     5e-36   3.3e-33       1      72 []     219     290 ..     219     290 .. 0.99

  Alignments for each domain:
  == domain 1  score: 78.2 bits;  conditional E-value: 4.3e-25
                EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEES CS
   ubiquitin  1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlr 70
                +++ktl+g +++++ve +d++e++Ke + ek+gip+ +qrLi++Gk Led +t+++y ++++st+ l+l+
  EFC39927.1  3 LFIKTLSGHSFPIDVECTDSIEKIKELVNEKQGIPPPSQRLILNGKKLEDGKTIQDYEMKQDSTIYLALS 72
                79*****************************************************************987 PP

  == domain 2  score: 98.3 bits;  conditional E-value: 2.4e-31
                 EEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin  10 kitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 +itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC39927.1  76 TITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 138
                 89**********************************************************986 PP

  == domain 3  score: 113.2 bits;  conditional E-value: 5e-36
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC39927.1 143 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 214
                 9********************************************************************986 PP

  == domain 4  score: 113.2 bits;  conditional E-value: 5e-36
                 EEEEETTSEEEEEEEETTSBHHHHHHHHHHHHTSSGGGEEEEETTEEE-TTSBHGGHTTSTTEEEEEEESSC CS
   ubiquitin   1 itvktldgkkitleveesdtveelKekiaekegipaeqqrLiysGkvLedertleeygiqdgstlhlvlrlr 72 
                 i+vktl+gk+itleve++dt+e++K ki++kegip++qqrLi++Gk+Led rtl++y+iq++stlhlvlrlr
  EFC39927.1 219 IFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLR 290
                 9********************************************************************986 PP

>> Rad60-SLD  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   39.6   0.1   5.3e-13   3.5e-10       1      68 [.       1      67 [.       1      71 [. 0.97
   2 !   45.9   0.3   5.6e-15   3.7e-12      11      72 .]      75     135 ..      66     135 .. 0.93
   3 !   57.9   0.7     1e-18   6.7e-16       1      72 []     141     211 ..     141     211 .. 0.98
   4 !   57.9   0.7     1e-18   6.7e-16       1      72 []     217     287 ..     217     287 .. 0.98

  Alignments for each domain:
  == domain 1  score: 39.6 bits;  conditional E-value: 5.3e-13
                EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEE CS
   Rad60-SLD  1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdti 68
                +++++k+ +g  + i V+ t  ++k++e   +k+gip+  ++rLi +G++L++ +t++d++++ ++ti
  EFC39927.1  1 MQLFIKTLSGHSFPIDVECTDSIEKIKELVNEKQGIPP-PSQRLILNGKKLEDGKTIQDYEMKQDSTI 67
                79************************************.***************************99 PP

  == domain 2  score: 45.9 bits;  conditional E-value: 5.6e-15
                 --EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD  11 kevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 ++++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC39927.1  75 DTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 135
                 68999***********************.******************************986 PP

  == domain 3  score: 57.9 bits;  conditional E-value: 1e-18
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC39927.1 141 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 211
                 89************************************.******************************986 PP

  == domain 4  score: 57.9 bits;  conditional E-value: 1e-18
                 EEEEEEESSS--EEEEEETTSBHHHHHHHHHHHHT----TT-EEEETTEE--TTSBGGGSS--TTEEEEEEX CS
   Rad60-SLD   1 ikiilkgkdgkevkikVkptttvskLieayrkkkgipeeqkvrLiFDGeeLdpnstvedldiedgdtidvvi 72 
                 ++i++k+ +gk+++++V+++ t+++++++ ++k+gip+ +++rLiF G++L++  t+ d+ i++++t+++v+
  EFC39927.1 217 MQIFVKTLTGKTITLEVESNDTIENVKSKIQDKEGIPP-DQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVL 287
                 89************************************.******************************986 PP

>> Ubiquitin_2  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.4   0.1   0.00024      0.16      21      81 ..      18      82 ..       5      85 .. 0.80
   2 !   20.3   0.1   8.6e-07   0.00057      20      80 ..      81     133 ..      75     134 .. 0.90
   3 !   21.3   0.2   4.3e-07   0.00028      16      80 ..     153     209 ..     141     210 .. 0.85
   4 !   21.3   0.2   4.3e-07   0.00028      16      80 ..     229     285 ..     217     286 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.4 bits;  conditional E-value: 0.00024
                 ETTSBHHHHHHHHHHHH---TTCEEEEE..E.-SSSSEEECS..SGCCSBCCCCT--TTEEEEEE CS
  Ubiquitin_2 21 sksltieelKekLelitGtspasmrLql..yddkkdnevskl..ddddalLgsYgvkdgmrihVi 81
                 + +++ie++Ke +    G++p s+rL l  ++ ++++++++   ++d++   + + +d  ++ V+
   EFC39927.1 18 ECTDSIEKIKELVNEKQGIPPPSQRLILngKKLEDGKTIQDYemKQDSTIYLALSWRDTITLEVE 82
                 55789***********************7755678888887776778887778888888888776 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 8.6e-07
                  EETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2  20 fsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC39927.1  81 VESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 133
                  57899***********************99........56678999********9999995 PP

  == domain 3  score: 21.3 bits;  conditional E-value: 4.3e-07
                  EEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2  16 serrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                   +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC39927.1 153 ITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 209
                  55678899************************99........56678999********9999995 PP

  == domain 4  score: 21.3 bits;  conditional E-value: 4.3e-07
                  EEEEEETTSBHHHHHHHHHHHH---TTCEEEEEE.-SSSSEEECSSGCCSBCCCCT--TTEEEEE CS
  Ubiquitin_2  16 serrfsksltieelKekLelitGtspasmrLqlyddkkdnevsklddddalLgsYgvkdgmrihV 80 
                   +  +++++tie++K+k++   G++p+++rL +          k  +d ++L++Y+++  +++h 
   EFC39927.1 229 ITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFA--------GKQLEDGRTLSDYNIQKESTLHL 285
                  55678899************************99........56678999********9999995 PP

>> TBK1_ULD  TANK binding kinase 1 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   11.7   0.0   0.00028      0.19      19      60 ..      17      56 ..      10      79 .. 0.83
   2 !   15.1   0.0   2.4e-05     0.016      19      53 ..      81     115 ..      70     135 .. 0.86
   3 !   15.2   0.1   2.2e-05     0.015      19      53 ..     157     191 ..     143     211 .. 0.86
   4 !   15.2   0.1   2.3e-05     0.016      19      53 ..     233     267 ..     219     285 .. 0.86

  Alignments for each domain:
  == domain 1  score: 11.7 bits;  conditional E-value: 0.00028
    TBK1_ULD 19 ihpyntvaifqeevakqTkiaaekQellfeghrlllepslka 60
                ++ ++ ++++ e+v ++  i++ +Q l+++g++l  e+ + +
  EFC39927.1 17 VECTDSIEKIKELVNEKQGIPPPSQRLILNGKKL--EDGKTI 56
                66789999************************87..444444 PP

  == domain 2  score: 15.1 bits;  conditional E-value: 2.4e-05
    TBK1_ULD  19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 +++++t++++  +++++  i++++Q l+f g++l 
  EFC39927.1  81 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 115
                 6889****************************973 PP

  == domain 3  score: 15.2 bits;  conditional E-value: 2.2e-05
    TBK1_ULD  19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 +++++t++++  +++++  i++++Q l+f g++l 
  EFC39927.1 157 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 191
                 6899****************************973 PP

  == domain 4  score: 15.2 bits;  conditional E-value: 2.3e-05
    TBK1_ULD  19 ihpyntvaifqeevakqTkiaaekQellfeghrll 53 
                 +++++t++++  +++++  i++++Q l+f g++l 
  EFC39927.1 233 VESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLE 267
                 6899****************************974 PP

>> Ubiquitin_5  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   12.2   0.1   0.00027      0.18      45      88 ..      24      67 ..      12      77 .. 0.73
   2 !   15.0   0.0   3.6e-05     0.024      35      93 ..      78     137 ..      70     142 .. 0.85
   3 !   15.8   0.1     2e-05     0.013      32      93 ..     151     213 ..     142     218 .. 0.85
   4 !   15.7   0.1   2.2e-05     0.015      32      92 ..     227     288 ..     217     292 .. 0.85

  Alignments for each domain:
  == domain 1  score: 12.2 bits;  conditional E-value: 0.00027
  Ubiquitin_5 45 kelvskiaeefglkensiKlilngklleldktLeeQgvknnskv 88
                 +++ + + e+ g+   s +lilngk+le +kt+++  +k++s +
   EFC39927.1 24 EKIKELVNEKQGIPPPSQRLILNGKKLEDGKTIQDYEMKQDSTI 67
                 3334444555566666789********************99987 PP

  == domain 2  score: 15.0 bits;  conditional E-value: 3.6e-05
  Ubiquitin_5  35 lletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+l
   EFC39927.1  78 TLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLRL 137
                  566666667889999999*****99***********************999875467765 PP

  == domain 3  score: 15.8 bits;  conditional E-value: 2e-05
  Ubiquitin_5  32 kkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLkl 93 
                  k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+l
   EFC39927.1 151 KTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLRL 213
                  55678888888999999**********************************999875467765 PP

  == domain 4  score: 15.7 bits;  conditional E-value: 2.2e-05
  Ubiquitin_5  32 kkklletkLdvtgkelvskiaeefglkensiKlilngklleldktLeeQgvknnskv.mvLk 92 
                  k  +le++ + t +++ ski ++ g+  ++ +li  gk+le ++tL + +++++s + +vL+
   EFC39927.1 227 KTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLhLVLR 288
                  55678888888999999**********************************99987546666 PP

>> Rad60-SLD_2  Ubiquitin-2 like Rad60 SUMO-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.9   0.0    0.0049       3.3      51      71 ..      41      61 ..       9      70 .. 0.87
   2 !   13.1   0.0   0.00011     0.075      14      87 ..      75     135 ..      67     139 .. 0.73
   3 !   13.3   0.0   9.8e-05     0.065      12      87 ..     150     211 ..     141     215 .. 0.72
   4 !   13.3   0.0    0.0001     0.068      12      87 ..     226     287 ..     217     290 .. 0.72

  Alignments for each domain:
  == domain 1  score: 7.9 bits;  conditional E-value: 0.0049
                 EEEEETTEEE-TTSBCCCCS- CS
  Rad60-SLD_2 51 lklilaGkiLennktlkelrl 71
                  +lil+Gk Le+ kt++++++
   EFC39927.1 41 QRLILNGKKLEDGKTIQDYEM 61
                 59**************99876 PP

  == domain 2  score: 13.1 bits;  conditional E-value: 0.00011
                  EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  14 DigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                  D+  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+
   EFC39927.1  75 DTITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVL 135
                  56666778888888888888.....4566634..34559****************965433......3566665 PP

  == domain 3  score: 13.3 bits;  conditional E-value: 9.8e-05
                  S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                  G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+
   EFC39927.1 150 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVL 211
                  66.6667778888888888888.....4566644..34559****************965433......3566665 PP

  == domain 4  score: 13.3 bits;  conditional E-value: 0.0001
                  S-EEEEEEEETT-BHHHHHHHHHHHS-TT-SSS--SCCCEEEEETTEEE-TTSBCCCCS-TTTTTTTS-EEEEEEE CS
  Rad60-SLD_2  12 GsDigpvkfsdaatvaelkekviaqWPkdkeekpksvndlklilaGkiLennktlkelrlplgevkggvtvmHvvv 87 
                  G+ +  ++ ++++t++++k k+     +dke  p  +++ +li aGk Le+ +tl++++++        +++H+v+
   EFC39927.1 226 GK-TITLEVESNDTIENVKSKI-----QDKEGIP--PDQQRLIFAGKQLEDGRTLSDYNIQKE------STLHLVL 287
                  66.6667778888888888888.....4566644..34559****************965433......3566665 PP

>> DUF2407  DUF2407 ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.0     0.028        18      27      63 ..      24      58 ..      12      68 .. 0.71
   2 !   14.7   0.1   5.3e-05     0.035       8      64 ..      70     123 ..      64     152 .. 0.83
   3 !   11.8   0.0   0.00042      0.28      14      64 ..     153     199 ..     144     212 .. 0.81
   4 !   11.7   0.0   0.00043      0.28      14      63 ..     229     274 ..     217     285 .. 0.82

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.028
     DUF2407 27 agLkqliRerlpaelasrrLrLIyaGrlLedttslas 63
                +++k+l+ e+    +     rLI +G+ Led +++++
  EFC39927.1 24 EKIKELVNEKQ--GIPPPSQRLILNGKKLEDGKTIQD 58
                55666666655..344444599*********999875 PP

  == domain 2  score: 14.7 bits;  conditional E-value: 5.3e-05
     DUF2407   8 sasipD.leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslass 64 
                 + s +D ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++ 
  EFC39927.1  70 ALSWRDtITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSDY 123
                 5588898999999..78899*******9997..777778899************9874 PP

  == domain 3  score: 11.8 bits;  conditional E-value: 0.00042
     DUF2407  14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslass 64 
                 ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++ 
  EFC39927.1 153 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSDY 199
                 566666..6789999999999987..67777789************99874 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 0.00043
     DUF2407  14 leLdipdpntttvagLkqliRerlpaelasrrLrLIyaGrlLedttslas 63 
                 ++L+++  ++ t++++k  i ++    +   + rLI+aG+ Led  +l++
  EFC39927.1 229 ITLEVE--SNDTIENVKSKIQDKE--GIPPDQQRLIFAGKQLEDGRTLSD 274
                 566666..6789999999999987..67777789************9986 PP

>> Ubiquitin_4  Ubiquitin-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    6.7   0.0     0.012       7.7       1      33 [.       1      33 [.       1      35 [. 0.93
   2 ?    5.0   0.1     0.037        25      58      84 ..      43      68 ..      40      73 .. 0.86
   3 ?    1.7   0.1      0.41   2.7e+02      11      32 ..      75      96 ..      66     100 .. 0.84
   4 ?    5.1   0.0     0.036        24      58      86 ..     107     134 ..     103     137 .. 0.83
   5 !    7.3   0.2    0.0071       4.7       1      32 [.     141     172 ..     141     176 .. 0.94
   6 ?    5.1   0.0     0.036        24      58      86 ..     183     210 ..     179     213 .. 0.83
   7 !    7.3   0.2    0.0071       4.7       1      32 [.     217     248 ..     217     252 .. 0.94
   8 ?    5.1   0.0     0.036        24      58      86 ..     259     286 ..     255     289 .. 0.83

  Alignments for each domain:
  == domain 1  score: 6.7 bits;  conditional E-value: 0.012
  Ubiquitin_4  1 lkvtvkkldgeslevvvkqnatvkdLkkaierk 33
                 +++ +k l+g+s+++ v+ + +++ +k+++++k
   EFC39927.1  1 MQLFIKTLSGHSFPIDVECTDSIEKIKELVNEK 33
                 7899*************************9875 PP

  == domain 2  score: 5.0 bits;  conditional E-value: 0.037
  Ubiquitin_4 58 LsfegekLkddkaklkeygirnksels 84
                 L+ +g+kL+ d +++++y ++++s+++
   EFC39927.1 43 LILNGKKLE-DGKTIQDYEMKQDSTIY 68
                 889999996.6789********99985 PP

  == domain 3  score: 1.7 bits;  conditional E-value: 0.41
  Ubiquitin_4 11 eslevvvkqnatvkdLkkaier 32
                  ++ ++v++n t++++k  i+ 
   EFC39927.1 75 DTITLEVESNDTIENVKSKIQD 96
                 678899************9996 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.036
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L+f g++L+ d  +l++y i+++s+l+ v
   EFC39927.1 107 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 134
                  889999986.6789***********9976 PP

  == domain 5  score: 7.3 bits;  conditional E-value: 0.0071
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32 
                  +++ vk l g+++ ++v++n t++++k  i+ 
   EFC39927.1 141 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 172
                  7899*************************997 PP

  == domain 6  score: 5.1 bits;  conditional E-value: 0.036
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L+f g++L+ d  +l++y i+++s+l+ v
   EFC39927.1 183 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 210
                  889999986.6789***********9976 PP

  == domain 7  score: 7.3 bits;  conditional E-value: 0.0071
  Ubiquitin_4   1 lkvtvkkldgeslevvvkqnatvkdLkkaier 32 
                  +++ vk l g+++ ++v++n t++++k  i+ 
   EFC39927.1 217 MQIFVKTLTGKTITLEVESNDTIENVKSKIQD 248
                  7899*************************997 PP

  == domain 8  score: 5.1 bits;  conditional E-value: 0.036
  Ubiquitin_4  58 LsfegekLkddkaklkeygirnkselsFv 86 
                  L+f g++L+ d  +l++y i+++s+l+ v
   EFC39927.1 259 LIFAGKQLE-DGRTLSDYNIQKESTLHLV 286
                  889999986.6789***********9976 PP

>> Sde2_N_Ubi  Silencing defective 2 N-terminal ubiquitin domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0       2.2   1.5e+03       2      41 ..       2      40 ..       1      63 [. 0.66
   2 ?    5.9   0.0     0.015        10      14      88 ..      74     140 ..      65     142 .. 0.81
   3 !   10.3   0.0   0.00071      0.47       2      88 ..     142     216 ..     141     217 .. 0.84
   4 !   10.5   0.0    0.0006       0.4       2      88 ..     218     292 ..     217     293 .] 0.84

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 2.2
  Sde2_N_Ubi  2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpes 41
                ++++++++g ++p +++ t  s   +++lv++ +  +p+s
  EFC39927.1  2 QLFIKTLSGHSFPIDVECT-DSIEKIKELVNEKQGIPPPS 40
                6789999998777777664.34445666666655555555 PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.015
  Sde2_N_Ubi  14 pstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGG 88 
                   t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGG
  EFC39927.1  74 RDTITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGG 140
                 678999999************9998777555.44555544.66..899999999999999....99********9 PP

  == domain 3  score: 10.3 bits;  conditional E-value: 0.00071
  Sde2_N_Ubi   2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGG 88 
                 +++v+++ g+    t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGG
  EFC39927.1 142 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGG 216
                 8999999996....999*****************998877555.45555544.66..99999****999999....99********9 PP

  == domain 4  score: 10.5 bits;  conditional E-value: 0.0006
  Sde2_N_Ubi   2 nvlvssfdgltlpstlsltlpstatvsdlvdklserlpeslkesliLttvsnkqlllssdvslssllassadsellslrllvrlrGG 88 
                 +++v+++ g+    t++l++ s+ t++++ +k++++      +   L  + + ql  ++  +ls++  ++++    +l+l++rlrGG
  EFC39927.1 218 QIFVKTLTGK----TITLEVESNDTIENVKSKIQDKEGIPPDQ-QRLIFAGK-QL--EDGRTLSDYNIQKES----TLHLVLRLRGG 292
                 8999999996....999*****************998877555.45555554.66..99999****999999....9*********9 PP

>> DUF3861  Domain of Unknown Function with PDB structure (DUF3861)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.2   0.0       1.8   1.2e+03      24      54 ..      14      44 ..       6      52 .. 0.77
   2 ?    5.7   0.0     0.025        17      21      59 ..      75     113 ..      60     121 .. 0.88
   3 ?    6.5   0.0     0.014       9.3      19      59 ..     149     189 ..     141     197 .. 0.87
   4 ?    6.4   0.0     0.015       9.8      19      59 ..     225     265 ..     217     269 .. 0.86

  Alignments for each domain:
  == domain 1  score: -0.2 bits;  conditional E-value: 1.8
     DUF3861 24 eFeaenhdDilkiverlkkkedldadeaaal 54
                 +++e+ d i ki e +++k+++ + +++ +
  EFC39927.1 14 PIDVECTDSIEKIKELVNEKQGIPPPSQRLI 44
                578999999****999999999986655555 PP

  == domain 2  score: 5.7 bits;  conditional E-value: 0.025
     DUF3861  21 kpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                  ++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC39927.1  75 DTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 113
                 489************************999887776665 PP

  == domain 3  score: 6.5 bits;  conditional E-value: 0.014
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC39927.1 149 TGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 189
                 5579*************************999887776665 PP

  == domain 4  score: 6.4 bits;  conditional E-value: 0.015
     DUF3861  19 eekpleFeaenhdDilkiverlkkkedldadeaaalavglk 59 
                 + k++++e+e+ d i ++  ++++ke++ +d+++ +  g +
  EFC39927.1 225 TGKTITLEVESNDTIENVKSKIQDKEGIPPDQQRLIFAGKQ 265
                 5579*************************999887766655 PP

>> DUF2870  Protein of unknown function (DUF2870)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.4   0.0      0.65   4.3e+02       3      24 ..      43      64 ..      41      71 .. 0.81
   2 ?    5.2   0.0     0.042        28       3      25 ..     107     129 ..     105     140 .. 0.79
   3 ?    5.2   0.0     0.042        28       3      25 ..     183     205 ..     181     216 .. 0.79
   4 ?    5.1   0.0     0.043        29       3      25 ..     259     281 ..     256     291 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.4 bits;  conditional E-value: 0.65
     DUF2870  3 lWwagkelqrgkklsdyvGkNe 24
                l + gk+l++gk+++dy  k +
  EFC39927.1 43 LILNGKKLEDGKTIQDYEMKQD 64
                56789***********976665 PP

  == domain 2  score: 5.2 bits;  conditional E-value: 0.042
     DUF2870   3 lWwagkelqrgkklsdyvGkNek 25 
                 l +agk+l++g++lsdy  + e 
  EFC39927.1 107 LIFAGKQLEDGRTLSDYNIQKES 129
                 789*************9766555 PP

  == domain 3  score: 5.2 bits;  conditional E-value: 0.042
     DUF2870   3 lWwagkelqrgkklsdyvGkNek 25 
                 l +agk+l++g++lsdy  + e 
  EFC39927.1 183 LIFAGKQLEDGRTLSDYNIQKES 205
                 789*************9766555 PP

  == domain 4  score: 5.1 bits;  conditional E-value: 0.043
     DUF2870   3 lWwagkelqrgkklsdyvGkNek 25 
                 l +agk+l++g++lsdy  + e 
  EFC39927.1 259 LIFAGKQLEDGRTLSDYNIQKES 281
                 889*************9765555 PP

>> UDP-g_GGTase  UDP-glucose:Glycoprotein Glucosyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.6   0.1    0.0029         2      52     104 ..     113     165 ..     112     169 .. 0.86
   2 !    8.6   0.1    0.0029         2      52     104 ..     189     241 ..     188     245 .. 0.86

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0029
                   EE-TTHHHHHEEEEE--SS-S--TT----EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  52 elregrssdiyeiesvgaeglsspkdegkevvltsfegktlyprvkrkpgkek 104
                   +l++gr+ + y+i++ ++ +l  + + g ++++++++gkt++++v+ ++  e+
    EFC39927.1 113 QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESNDTIEN 165
                   5889**********99999865555679*****************99987776 PP

  == domain 2  score: 8.6 bits;  conditional E-value: 0.0029
                   EE-TTHHHHHEEEEE--SS-S--TT----EEEE-STT-EEE--EEEE-TT--- CS
  UDP-g_GGTase  52 elregrssdiyeiesvgaeglsspkdegkevvltsfegktlyprvkrkpgkek 104
                   +l++gr+ + y+i++ ++ +l  + + g ++++++++gkt++++v+ ++  e+
    EFC39927.1 189 QLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESNDTIEN 241
                   5889**********99999865555679*****************99987776 PP

>> Methyltrans_RNA  RNA methyltransferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    8.3   0.0    0.0019       1.3       2      61 ..     124     182 ..     123     188 .. 0.82
   2 !    8.4   0.0    0.0018       1.2       2      61 ..     200     258 ..     199     267 .. 0.82

  Alignments for each domain:
  == domain 1  score: 8.3 bits;  conditional E-value: 0.0019
                      EEEHHHHHHHHTTTT--TT-EEEEEESSSEEEEEEEEEEESSEE.EEEEEEEEE---SSSS CS
  Methyltrans_RNA   2 sltdeeahHlvkVlRlkegdeiklfdgdgkeyeaeieeiskkkv.tvkilekeeenkespe 61 
                      ++++e + Hl  VlRl+ g +i +    gk ++ e+e+++  +  + ki++ke +++++++
       EFC39927.1 124 NIQKESTLHL--VLRLRGGMQIFVKTLTGKTITLEVESNDTIENvKSKIQDKEGIPPDQQR 182
                      5788999999..*************************998765427777777777766655 PP

  == domain 2  score: 8.4 bits;  conditional E-value: 0.0018
                      EEEHHHHHHHHTTTT--TT-EEEEEESSSEEEEEEEEEEESSE.EEEEEEEEEE---SSSS CS
  Methyltrans_RNA   2 sltdeeahHlvkVlRlkegdeiklfdgdgkeyeaeieeiskkk.vtvkilekeeenkespe 61 
                      ++++e + Hl  VlRl+ g +i +    gk ++ e+e+++  + v+ ki++ke +++++++
       EFC39927.1 200 NIQKESTLHL--VLRLRGGMQIFVKTLTGKTITLEVESNDTIEnVKSKIQDKEGIPPDQQR 258
                      5788999999..*************************998765157778777777776655 PP

>> ACT_5  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.5   0.1     0.047        31      35      53 ..      76      94 ..      74      95 .. 0.91
   2 ?    6.0   0.1     0.016        11      33      53 ..     150     170 ..     140     171 .. 0.82
   3 ?    6.0   0.1     0.016        11      33      53 ..     226     246 ..     216     247 .. 0.82

  Alignments for each domain:
  == domain 1  score: 4.5 bits;  conditional E-value: 0.047
       ACT_5 35 rieltVesersvelLsnQl 53
                +i+l+Ves++++e++ +++
  EFC39927.1 76 TITLEVESNDTIENVKSKI 94
                59*************9998 PP

  == domain 2  score: 6.0 bits;  conditional E-value: 0.016
       ACT_5  33 tvrieltVesersvelLsnQl 53 
                   +i+l+Ves++++e++ +++
  EFC39927.1 150 GKTITLEVESNDTIENVKSKI 170
                 468**************9998 PP

  == domain 3  score: 6.0 bits;  conditional E-value: 0.016
       ACT_5  33 tvrieltVesersvelLsnQl 53 
                   +i+l+Ves++++e++ +++
  EFC39927.1 226 GKTITLEVESNDTIENVKSKI 246
                 468**************9998 PP

>> ProRS-C_2  Prolyl-tRNA synthetase, C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   0.1       0.1        68      12      26 ..      22      36 ..      15      37 .. 0.82
   2 ?    5.8   0.1     0.023        15       6      26 ..      80     100 ..      76     101 .. 0.85
   3 ?    5.8   0.1     0.023        15       6      26 ..     156     176 ..     152     177 .. 0.85
   4 ?    5.8   0.1     0.023        15       6      26 ..     232     252 ..     228     253 .. 0.85

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.1
                .HHHHHHHCTTT-SE CS
   ProRS-C_2 12 llenikeklsekkGv 26
                  e+ike ++ek+G+
  EFC39927.1 22 SIEKIKELVNEKQGI 36
                579**********98 PP

  == domain 2  score: 5.8 bits;  conditional E-value: 0.023
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n   en+k k+++k G+
  EFC39927.1  80 EVESNDTIENVKSKIQDKEGI 100
                 56789*************997 PP

  == domain 3  score: 5.8 bits;  conditional E-value: 0.023
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n   en+k k+++k G+
  EFC39927.1 156 EVESNDTIENVKSKIQDKEGI 176
                 56789*************997 PP

  == domain 4  score: 5.8 bits;  conditional E-value: 0.023
                 S--....HHHHHHHCTTT-SE CS
   ProRS-C_2   6 aenvnlllenikeklsekkGv 26 
                 ++++n   en+k k+++k G+
  EFC39927.1 232 EVESNDTIENVKSKIQDKEGI 252
                 56789*************997 PP

>> UN_NPL4  Nuclear pore localisation protein NPL4
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.4   0.0       1.4   9.6e+02      19      77 ..      16      69 ..       7      72 .. 0.73
   2 ?    4.5   0.0     0.073        48      16      46 ..      77     107 ..      71     134 .. 0.84
   3 ?    4.7   0.0     0.064        42      16      46 ..     153     183 ..     140     210 .. 0.83
   4 ?    4.7   0.0     0.066        44      16      46 ..     229     259 ..     216     285 .. 0.84

  Alignments for each domain:
  == domain 1  score: 0.4 bits;  conditional E-value: 1.4
                EE-TTSBHHHHHHHHHHHSS-STTT-EEESSTTCGCCCSSSSSSCCCTCH--TT-EEEE CS
     UN_NPL4 19 eisekstlktllekvaeelkfsengfslylernkttelvssssksvkevglkhGdmlyL 77
                +++ +  +++++e+v+e+ +++   + l l+ +k   l  ++ k++++ ++k+   +yL
  EFC39927.1 16 DVECTDSIEKIKELVNEKQGIPPPSQRLILNGKK---L--EDGKTIQDYEMKQDSTIYL 69
                5666777888999999999999888888887544...4..4556777777766666666 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.073
                 EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4  16 kRieisekstlktllekvaeelkfsengfsl 46 
                 + +e++++ t+++ ++k++++ +++  ++ l
  EFC39927.1  77 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 107
                 568999****************999988776 PP

  == domain 3  score: 4.7 bits;  conditional E-value: 0.064
                 EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4  16 kRieisekstlktllekvaeelkfsengfsl 46 
                 + +e++++ t+++ ++k++++ +++  ++ l
  EFC39927.1 153 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 183
                 568999****************999988776 PP

  == domain 4  score: 4.7 bits;  conditional E-value: 0.066
                 EEEEE-TTSBHHHHHHHHHHHSS-STTT-EE CS
     UN_NPL4  16 kRieisekstlktllekvaeelkfsengfsl 46 
                 + +e++++ t+++ ++k++++ +++  ++ l
  EFC39927.1 229 ITLEVESNDTIENVKSKIQDKEGIPPDQQRL 259
                 568999***************9999888776 PP

>> DUF218  DUF218 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.0     0.002       1.3      27      74 ..      33      91 ..      18      95 .. 0.81
   2 ?    3.2   0.1      0.12        82      58      74 ..     151     167 ..      97     171 .. 0.75
   3 ?    3.3   0.1      0.12        80      58      74 ..     227     243 ..     171     247 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.002
      DUF218 27 g........kiivsGg..gadedvseaeamaeylrelgvp.eeailledrsrnTeenar 74
                +        ++i+ G+  ++++++++ e+ ++  + l  + ++ i+le +s++T en++
  EFC39927.1 33 KqgipppsqRLILNGKklEDGKTIQDYEMKQDSTIYLALSwRDTITLEVESNDTIENVK 91
                4446654445999999986668999999999999999999999**************86 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.12
      DUF218  58 eailledrsrnTeenar 74 
                 + i+le +s++T en++
  EFC39927.1 151 KTITLEVESNDTIENVK 167
                 3699***********86 PP

  == domain 3  score: 3.3 bits;  conditional E-value: 0.12
      DUF218  58 eailledrsrnTeenar 74 
                 + i+le +s++T en++
  EFC39927.1 227 KTITLEVESNDTIENVK 243
                 3699***********86 PP

>> RBD  Raf-like Ras-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.1   0.0     0.072        48      10      42 ..      75     107 ..      66     123 .. 0.82
   2 ?    4.5   0.0     0.056        37       9      42 ..     150     183 ..     149     199 .. 0.85
   3 ?    4.5   0.0     0.056        37       9      42 ..     226     259 ..     225     275 .. 0.85

  Alignments for each domain:
  == domain 1  score: 4.1 bits;  conditional E-value: 0.072
         RBD  10 qrtvvevkpgetvrdaLekalkkRglnpsacaV 42 
                  + + ev++++t++++ +k+  k g+ p++  +
  EFC39927.1  75 DTITLEVESNDTIENVKSKIQDKEGIPPDQQRL 107
                 67899*********************9987655 PP

  == domain 2  score: 4.5 bits;  conditional E-value: 0.056
         RBD   9 gqrtvvevkpgetvrdaLekalkkRglnpsacaV 42 
                 g++ + ev++++t++++ +k+  k g+ p++  +
  EFC39927.1 150 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRL 183
                 578899*********************9987655 PP

  == domain 3  score: 4.5 bits;  conditional E-value: 0.056
         RBD   9 gqrtvvevkpgetvrdaLekalkkRglnpsacaV 42 
                 g++ + ev++++t++++ +k+  k g+ p++  +
  EFC39927.1 226 GKTITLEVESNDTIENVKSKIQDKEGIPPDQQRL 259
                 578899*********************9987655 PP

>> DUF969  Protein of unknown function (DUF969)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.8   0.0       2.6   1.7e+03      69     109 ..      31      71 ..      30      74 .. 0.86
   2 ?    4.4   0.0     0.033        22      70     117 ..      96     143 ..      92     150 .. 0.88
   3 ?    4.4   0.0     0.032        21      70     117 ..     172     219 ..     167     226 .. 0.88
   4 ?    1.5   0.0      0.25   1.6e+02      70     113 ..     248     291 ..     243     293 .] 0.90

  Alignments for each domain:
  == domain 1  score: -1.8 bits;  conditional E-value: 2.6
      DUF969  69 leraGLkeraaklikkikkatagrlllvYllirelaaalgl 109
                  e++G+   +++li + kk+  g+ +  Y + +  ++ l l
  EFC39927.1  31 NEKQGIPPPSQRLILNGKKLEDGKTIQDYEMKQDSTIYLAL 71 
                 58899999999***************999998888887776 PP

  == domain 2  score: 4.4 bits;  conditional E-value: 0.033
      DUF969  70 eraGLkeraaklikkikkatagrlllvYllirelaaalglslgGhaqf 117
                 ++ G+    ++li   k++  gr l+ Y + +e +  l l+l G  q+
  EFC39927.1  96 DKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQI 143
                 67888889999*****************************99887774 PP

  == domain 3  score: 4.4 bits;  conditional E-value: 0.032
      DUF969  70 eraGLkeraaklikkikkatagrlllvYllirelaaalglslgGhaqf 117
                 ++ G+    ++li   k++  gr l+ Y + +e +  l l+l G  q+
  EFC39927.1 172 DKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQI 219
                 67888889999*****************************99887774 PP

  == domain 4  score: 1.5 bits;  conditional E-value: 0.25
      DUF969  70 eraGLkeraaklikkikkatagrlllvYllirelaaalglslgG 113
                 ++ G+    ++li   k++  gr l+ Y + +e +  l l+l G
  EFC39927.1 248 DKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRG 291
                 67888889999***************************999987 PP

>> YcgR_2  Flagellar protein YcgR
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.1      0.13        87       4      26 ..      75      97 ..      75     109 .. 0.87
   2 ?    5.4   0.1     0.031        21       3      26 ..     150     173 ..     149     185 .. 0.89
   3 ?    5.4   0.1     0.031        21       3      26 ..     226     249 ..     225     261 .. 0.89

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.13
                SEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2  4 dkveieiesgdgekryksrvvdi 26
                d +++e+es+d  +++ks+++d 
  EFC39927.1 75 DTITLEVESNDTIENVKSKIQDK 97
                5799*********99******85 PP

  == domain 2  score: 5.4 bits;  conditional E-value: 0.031
                 TSEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2   3 Gdkveieiesgdgekryksrvvdi 26 
                 G+ +++e+es+d  +++ks+++d 
  EFC39927.1 150 GKTITLEVESNDTIENVKSKIQDK 173
                 899*******************85 PP

  == domain 3  score: 5.4 bits;  conditional E-value: 0.031
                 TSEEEEEEEETTEEEEEEEEEEEE CS
      YcgR_2   3 Gdkveieiesgdgekryksrvvdi 26 
                 G+ +++e+es+d  +++ks+++d 
  EFC39927.1 226 GKTITLEVESNDTIENVKSKIQDK 249
                 899*******************85 PP

>> Tash_PEST  Tash protein PEST motif
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.9   0.2     0.022        15       7      14 ..      76      83 ..      76      85 .. 0.90
   2 ?    5.9   0.2     0.022        15       7      14 ..     152     159 ..     152     161 .. 0.90
   3 ?    5.9   0.2     0.022        15       7      14 ..     228     235 ..     228     237 .. 0.90

  Alignments for each domain:
  == domain 1  score: 5.9 bits;  conditional E-value: 0.022
   Tash_PEST  7 TIpVEigS 14
                TI++E++S
  EFC39927.1 76 TITLEVES 83
                9******* PP

  == domain 2  score: 5.9 bits;  conditional E-value: 0.022
   Tash_PEST   7 TIpVEigS 14 
                 TI++E++S
  EFC39927.1 152 TITLEVES 159
                 9******* PP

  == domain 3  score: 5.9 bits;  conditional E-value: 0.022
   Tash_PEST   7 TIpVEigS 14 
                 TI++E++S
  EFC39927.1 228 TITLEVES 235
                 9******* PP

>> Big_7  Bacterial Ig domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.6   0.0       3.6   2.4e+03      13      39 ..       7      31 ..       6      58 .. 0.80
   2 ?    2.4   0.0      0.41   2.7e+02      17      42 ..      75      98 ..      62     119 .. 0.75
   3 ?    3.4   0.0       0.2   1.3e+02      13      42 ..     147     174 ..     146     195 .. 0.77
   4 ?    3.4   0.0       0.2   1.3e+02      13      42 ..     223     250 ..     222     270 .. 0.77

  Alignments for each domain:
  == domain 1  score: -0.6 bits;  conditional E-value: 3.6
                -EBTSEEEEEEEEE-SS-EEEEEEEET CS
       Big_7 13 tvsggtvtisasAsddggvskVefyvd 39
                t+sg ++ i ++ +d+  ++k++  v+
  EFC39927.1  7 TLSGHSFPIDVECTDS--IEKIKELVN 31
                5667889999999999..666665555 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.41
                SEEEEEEEEE-SS-EEEEEEEETTEE CS
       Big_7 17 gtvtisasAsddggvskVefyvdgtl 42
                +t+t++++ +d  ++++V+  +++++
  EFC39927.1 75 DTITLEVESND--TIENVKSKIQDKE 98
                45555555555..5999998888776 PP

  == domain 3  score: 3.4 bits;  conditional E-value: 0.2
                 -EBTSEEEEEEEEE-SS-EEEEEEEETTEE CS
       Big_7  13 tvsggtvtisasAsddggvskVefyvdgtl 42 
                 t++g+t+t++++ +d   +++V+  +++++
  EFC39927.1 147 TLTGKTITLEVESNDT--IENVKSKIQDKE 174
                 5667788888887777..999988887766 PP

  == domain 4  score: 3.4 bits;  conditional E-value: 0.2
                 -EBTSEEEEEEEEE-SS-EEEEEEEETTEE CS
       Big_7  13 tvsggtvtisasAsddggvskVefyvdgtl 42 
                 t++g+t+t++++ +d   +++V+  +++++
  EFC39927.1 223 TLTGKTITLEVESNDT--IENVKSKIQDKE 250
                 5667788888887777..999988887766 PP

>> ACT_4  ACT domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.3   0.0      0.18   1.2e+02      51      75 ..      76     100 ..      51     101 .. 0.82
   2 ?    3.2   0.0       0.2   1.3e+02      51      75 ..     152     176 ..     145     177 .. 0.86
   3 ?    3.2   0.0       0.2   1.3e+02      51      75 ..     228     252 ..     221     253 .. 0.86

  Alignments for each domain:
  == domain 1  score: 3.3 bits;  conditional E-value: 0.18
       ACT_4  51 kitveVkdvehLsrviakLraipgV 75 
                 +it+eV++ + +++v  k++  +g+
  EFC39927.1  76 TITLEVESNDTIENVKSKIQDKEGI 100
                 69****************9976665 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.2
       ACT_4  51 kitveVkdvehLsrviakLraipgV 75 
                 +it+eV++ + +++v  k++  +g+
  EFC39927.1 152 TITLEVESNDTIENVKSKIQDKEGI 176
                 69****************9976665 PP

  == domain 3  score: 3.2 bits;  conditional E-value: 0.2
       ACT_4  51 kitveVkdvehLsrviakLraipgV 75 
                 +it+eV++ + +++v  k++  +g+
  EFC39927.1 228 TITLEVESNDTIENVKSKIQDKEGI 252
                 69****************9976665 PP

>> ORF11CD3  ORF11CD3 domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.4   0.0      0.13        87      24      50 ..     117     143 ..     116     145 .. 0.93
   2 ?    3.4   0.0      0.13        87      24      50 ..     193     219 ..     192     221 .. 0.93
   3 ?   -0.2   0.0       1.7   1.1e+03      24      37 ..     269     282 ..     268     290 .. 0.76

  Alignments for each domain:
  == domain 1  score: 3.4 bits;  conditional E-value: 0.13
    ORF11CD3  24 GrgLsewKqkKpqltqkveeLeeklQl 50 
                 Gr+Ls++ ++K   +  v +L+  +Q+
  EFC39927.1 117 GRTLSDYNIQKESTLHLVLRLRGGMQI 143
                 9***********999999999999997 PP

  == domain 2  score: 3.4 bits;  conditional E-value: 0.13
    ORF11CD3  24 GrgLsewKqkKpqltqkveeLeeklQl 50 
                 Gr+Ls++ ++K   +  v +L+  +Q+
  EFC39927.1 193 GRTLSDYNIQKESTLHLVLRLRGGMQI 219
                 9***********999999999999997 PP

  == domain 3  score: -0.2 bits;  conditional E-value: 1.7
    ORF11CD3  24 GrgLsewKqkKpql 37 
                 Gr+Ls++ ++K   
  EFC39927.1 269 GRTLSDYNIQKEST 282
                 9******9988655 PP

>> Phage_sheath_1N  Phage tail sheath protein beta-sandwich domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.7   3.6      0.13        88      26      39 ..     149     162 ..      49     284 .. 0.60

  Alignments for each domain:
  == domain 1  score: 3.7 bits;  conditional E-value: 0.13
                      GGGGEEEEEEEHSS CS
  Phage_sheath_1N  26 rGnritvevtsgad 39 
                      +G+ it+ev+s+++
       EFC39927.1 149 TGKTITLEVESNDT 162
                      44444444444444 PP

>> HAMP_N3  HAMP N-terminal domain 3
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.5   0.1     0.077        51      32      43 .]      84      95 ..      84      95 .. 0.93
   2 ?    3.5   0.1     0.077        51      32      43 .]     160     171 ..     160     171 .. 0.93
   3 ?    3.5   0.1     0.077        51      32      43 .]     236     247 ..     236     247 .. 0.93

  Alignments for each domain:
  == domain 1  score: 3.5 bits;  conditional E-value: 0.077
                HHHHHHHHHHH- CS
     HAMP_N3 32 netieqvRgnLk 43
                n+tie+v+++++
  EFC39927.1 84 NDTIENVKSKIQ 95
                9********986 PP

  == domain 2  score: 3.5 bits;  conditional E-value: 0.077
                 HHHHHHHHHHH- CS
     HAMP_N3  32 netieqvRgnLk 43 
                 n+tie+v+++++
  EFC39927.1 160 NDTIENVKSKIQ 171
                 9********986 PP

  == domain 3  score: 3.5 bits;  conditional E-value: 0.077
                 HHHHHHHHHHH- CS
     HAMP_N3  32 netieqvRgnLk 43 
                 n+tie+v+++++
  EFC39927.1 236 NDTIENVKSKIQ 247
                 9********986 PP

>> PI3K_p85B  PI3-kinase family, p85-binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.0         2   1.3e+03       3      18 ..      15      30 ..      14      36 .. 0.78
   2 ?    4.0   0.1     0.062        41       1      18 [.      77      94 ..      77      97 .. 0.92
   3 ?    4.0   0.1     0.062        41       1      18 [.     153     170 ..     153     173 .. 0.92
   4 ?    4.0   0.1     0.062        41       1      18 [.     229     246 ..     229     249 .. 0.92

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 2
   PI3K_p85B  3 lrvsreatLseiKeeL 18
                ++v+ + ++++iKe +
  EFC39927.1 15 IDVECTDSIEKIKELV 30
                6788899999999854 PP

  == domain 2  score: 4.0 bits;  conditional E-value: 0.062
   PI3K_p85B  1 itlrvsreatLseiKeeL 18
                itl+v+++ t++++K+++
  EFC39927.1 77 ITLEVESNDTIENVKSKI 94
                89*************986 PP

  == domain 3  score: 4.0 bits;  conditional E-value: 0.062
   PI3K_p85B   1 itlrvsreatLseiKeeL 18 
                 itl+v+++ t++++K+++
  EFC39927.1 153 ITLEVESNDTIENVKSKI 170
                 89*************986 PP

  == domain 4  score: 4.0 bits;  conditional E-value: 0.062
   PI3K_p85B   1 itlrvsreatLseiKeeL 18 
                 itl+v+++ t++++K+++
  EFC39927.1 229 ITLEVESNDTIENVKSKI 246
                 89*************986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (293 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       377  (0.0210274); expected 358.6 (0.02)
Passed bias filter:                      258  (0.0143901); expected 358.6 (0.02)
Passed Vit filter:                        43  (0.00239835); expected 17.9 (0.001)
Passed Fwd filter:                        28  (0.00156172); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              27  [number of targets reported over threshold]
# CPU time: 0.67u 0.32s 00:00:00.99 Elapsed: 00:00:00.53
# Mc/sec: 1650.47
//
Query:       EFC39928.1  [L=631]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
   9.6e-136  441.4   5.9    2.3e-15   56.1   0.0   11.3 15  DUF4116   Domain of unknown function (DUF4116)
     0.0028   17.6   0.3        1.5    8.8   0.0    3.5  3  AfsA      A-factor biosynthesis hotdog domain
  ------ inclusion threshold ------
      0.069   13.8   0.1       0.33   11.6   0.1    2.2  1  VWA_2     von Willebrand factor type A domain


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   13.8   0.0   5.9e-06     0.035      13      47 ..      90     124 ..      86     126 .. 0.82
   2 !   27.3   0.1   3.7e-10   2.2e-06       3      41 ..     105     142 ..     103     150 .. 0.95
   3 !   32.5   0.0   8.4e-12     5e-08       1      45 [.     127     171 ..     127     175 .. 0.94
   4 !   44.5   0.0   1.6e-15   9.5e-12       1      49 []     152     200 ..     152     200 .. 0.98
   5 !   27.8   0.0   2.5e-10   1.5e-06       1      44 [.     177     220 ..     177     225 .. 0.95
   6 !   52.2   0.0   6.1e-18   3.6e-14       1      49 []     228     276 ..     228     276 .. 0.98
   7 !   49.2   0.0   5.4e-17   3.2e-13       3      49 .]     255     301 ..     255     301 .. 0.98
   8 !   37.2   0.0   2.9e-13   1.7e-09       1      49 []     278     326 ..     278     326 .. 0.97
   9 !   30.1   0.0     5e-11     3e-07       4      49 .]     306     351 ..     303     351 .. 0.97
  10 !   43.7   0.0   2.7e-15   1.6e-11       2      48 ..     329     375 ..     328     376 .. 0.96
  11 !   39.0   0.1   7.9e-14   4.7e-10       1      49 []     353     401 ..     353     401 .. 0.96
  12 !   56.1   0.0   3.8e-19   2.3e-15       1      49 []     403     451 ..     403     451 .. 0.99
  13 !   26.7   0.0   5.5e-10   3.3e-06      18      49 .]     445     476 ..     442     476 .. 0.96
  14 !   27.3   0.1   3.5e-10   2.1e-06      10      49 .]     504     543 ..     499     543 .. 0.88
  15 !   28.9   0.6   1.2e-10   6.9e-07       1      44 [.     545     588 ..     545     593 .. 0.95

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 5.9e-06
     DUF4116  13 gsalkylseeLknDkeivlkAvkqngtalsyasee 47 
                 + + +y++  +  + +++ kAvk n t+l+y++ +
  EFC39928.1  90 PQICQYFPMVWLGNVDFIRKAVKENATILKYVPIS 124
                 556678888888899*****************955 PP

  == domain 2  score: 27.3 bits;  conditional E-value: 3.7e-10
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 +++ +avk n  +lky++ +L  D+ei+l Avk +g++l
  EFC39928.1 105 DFIRKAVKENATILKYVPISLI-DREIMLDAVKLDGKIL 142
                 8********************8.*************988 PP

  == domain 3  score: 32.5 bits;  conditional E-value: 8.4e-12
     DUF4116   1 DrEivleavkkngsalky.lseeLknDkeivlkAvkqngtalsyas 45 
                 DrEi+l avk +g++l + +  e++ D eiv +A+ qng alsya 
  EFC39928.1 127 DREIMLDAVKLDGKILFNgAV-EFRTDEEIVWQAISQNGLALSYAG 171
                 9***************99666.**********************96 PP

  == domain 4  score: 44.5 bits;  conditional E-value: 1.6e-15
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eiv++a+++ng+al y+ + ++ Dk +vl+A+ +n  a++y s+ L+
  EFC39928.1 152 DEEIVWQAISQNGLALSYAGPFFQDDKRFVLQAISSNAMAYEYTSHRLK 200
                 9********************************************9986 PP

  == domain 5  score: 27.8 bits;  conditional E-value: 2.5e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 D+ +vl+a+++n +a++y s++Lk D ++v + +++ ++ l ++
  EFC39928.1 177 DKRFVLQAISSNAMAYEYTSHRLKLDLDVVEATLQKEPYMLQHV 220
                 899***********************************999876 PP

  == domain 6  score: 52.2 bits;  conditional E-value: 6.1e-18
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++++vl+avk+ g +l+++s+eLknD e+v +Av ++g+al yase+L+
  EFC39928.1 228 NKQLVLQAVKRAGGVLQFASDELKNDYEVVYEAVTNYGYALAYASENLK 276
                 799*******************************************997 PP

  == domain 7  score: 49.2 bits;  conditional E-value: 5.4e-17
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 E+v eav+++g+al y+se+Lk ++ iv+kAv+qng al+y+s eLr
  EFC39928.1 255 EVVYEAVTNYGYALAYASENLKGNRSIVIKAVQQNGRALEYVSLELR 301
                 899****************************************9998 PP

  == domain 8  score: 37.2 bits;  conditional E-value: 2.9e-13
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +r iv +av++ng al+y+s eL++ + +vl+A++ + ta++ ase+++
  EFC39928.1 278 NRSIVIKAVQQNGRALEYVSLELRSERAVVLEAMQHDATAYYWASESMK 326
                 799******************************************9875 PP

  == domain 9  score: 30.1 bits;  conditional E-value: 5e-11
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 +vlea++++  a++ +se++k+ k+++l Av++ g++l y++ +Lr
  EFC39928.1 306 VVLEAMQHDATAYYWASESMKRQKDLALMAVQKQGICLQYVPSNLR 351
                 8*****************************************9998 PP

  == domain 10  score: 43.7 bits;  conditional E-value: 2.7e-15
     DUF4116   2 rEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeL 48 
                 ++++l av+k g +l+y++++L+ D+e+vl+A+kq+ +a+ y++  L
  EFC39928.1 329 KDLALMAVQKQGICLQYVPSNLRADREVVLAALKQDFFAFQYVDSTL 375
                 799****************************************9877 PP

  == domain 11  score: 39.0 bits;  conditional E-value: 7.9e-14
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 DrE+vl a+k++ +a++y+++ L+++k iv++A++ n+++l  ++ eL+
  EFC39928.1 353 DREVVLAALKQDFFAFQYVDSTLQRNKSIVMEAIEFNPFVLMSVCAELK 401
                 9****************************************99998886 PP

  == domain 12  score: 56.1 bits;  conditional E-value: 3.8e-19
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+E+v  av+kng  l+++s++L nD+++vl+Av+++g a s+as eL+
  EFC39928.1 403 DKEVVISAVSKNGHTLQFASPRLLNDRQVVLEAVRNCGRAVSFASTELK 451
                 9**********************************************97 PP

  == domain 13  score: 26.7 bits;  conditional E-value: 5.5e-10
     DUF4116  18 ylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 ++s eLk+D+e+v +Av+q+ +al+ as+e+r
  EFC39928.1 445 FASTELKSDWEVVYEAVNQDVFALNWASNEIR 476
                 99****************************98 PP

  == domain 14  score: 27.3 bits;  conditional E-value: 3.5e-10
     DUF4116  10 kkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 + +g   + +++eLk D+e++ +A+k n +a+++++e++r
  EFC39928.1 504 REDGRFMRCANDELKMDREFITEAIKLNAIAFPFIPEKFR 543
                 5567777889***************************987 PP

  == domain 15  score: 28.9 bits;  conditional E-value: 1.2e-10
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsya 44 
                 D+ ++le++++ng ++++l + +k D ei+++A k + t+++++
  EFC39928.1 545 DKKFILELLQHNGDVYEHLKKQYKVDLEIMIEAAKHCATCYRFF 588
                 999**************************************997 PP

>> AfsA  A-factor biosynthesis hotdog domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    0.1   0.0      0.12   7.2e+02      70      98 ..     177     205 ..     159     237 .. 0.73
   2 !    3.9   0.0    0.0084        50      65      92 ..     348     375 ..     295     388 .. 0.84
   3 !    8.8   0.0   0.00025       1.5      19      84 ..     402     467 ..     390     474 .. 0.86

  Alignments for each domain:
  == domain 1  score: 0.1 bits;  conditional E-value: 0.12
        AfsA  70 dtafildslslsfaafaeldvpvvvrvev 98 
                 d++f+l+++s + +a++++   + + ++v
  EFC39928.1 177 DKRFVLQAISSNAMAYEYTSHRLKLDLDV 205
                 899********999998887755555544 PP

  == domain 2  score: 3.9 bits;  conditional E-value: 0.0084
        AfsA  65 lgvpldtafildslslsfaafaeldvpv 92 
                 + + +d++++l++l+ +f+af ++d+++
  EFC39928.1 348 SNLRADREVVLAALKQDFFAFQYVDSTL 375
                 56889*******************9954 PP

  == domain 3  score: 8.8 bits;  conditional E-value: 0.00025
        AfsA  19 gegrlsvtarlprshefffdhesdhvdgllllEalRQaaiavaHtalgvpldtafildslslsfaa 84 
                 +  +++++a+ ++ h++ f+ +    d  ++lEa+R  + av+ ++ ++  d++++  +++ +++a
  EFC39928.1 402 DDKEVVISAVSKNGHTLQFASPRLLNDRQVVLEAVRNCGRAVSFASTELKSDWEVVYEAVNQDVFA 467
                 4567888999999*********************************************99988765 PP

>> VWA_2  von Willebrand factor type A domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.6   0.1   5.5e-05      0.33       8      93 ..     187     279 ..     185     293 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.6 bits;  conditional E-value: 5.5e-05
       VWA_2   8 SgSmrngdygptrleaakdaveallkslpgd..rvglvtfsdgpevlipl.tkdkakilnalrnleak.....gggtnlaaaLqlarkalkkrr 93 
                 S+ m+ + y+  rl    d vea l++ p +  +v+l +fs++ +++++  ++  + ++ a ++l+ +     +  tn++ aL +a++ lk +r
  EFC39928.1 187 SNAMAYE-YTSHRLKLDLDVVEATLQKEPYMlqHVNLHAFSNNKQLVLQAvKRAGGVLQFASDELKNDyevvyEAVTNYGYALAYASENLKGNR 279
                 6777765.8999**************9986666**********999998725556666667778887799999999***************987 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (631 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       746  (0.0416086); expected 358.6 (0.02)
Passed bias filter:                      438  (0.0244297); expected 358.6 (0.02)
Passed Vit filter:                        28  (0.00156172); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.73u 0.35s 00:00:01.08 Elapsed: 00:00:00.55
# Mc/sec: 3442.35
//
Query:       EFC39929.1  [L=524]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    0.00054   20.3   7.3    0.00054   20.3   7.3    2.3  2  EGF_2     EGF-like domain
     0.0037   17.2   0.0       0.38   10.9   0.0    3.2  3  NHL       NHL repeat
  ------ inclusion threshold ------
        7.2    7.0   9.2        5.3    7.4   4.1    2.6  2  EGF       EGF-like domain
        9.6    7.0  14.1        6.5    7.5   7.2    2.8  2  hEGF      Human growth factor-like EGF


Domain annotation for each model (and alignments):
>> EGF_2  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   0.5      0.45     2e+03       5      14 ..     242     251 ..     238     253 .. 0.70
   2 !   20.3   7.3   1.2e-07   0.00054       5      32 .]     259     285 ..     255     285 .. 0.91

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.45
       EGF_2   5 deiCgghGtC 14 
                 + iC+++ tC
  EFC39929.1 242 GMICSNQTTC 251
                 5678888777 PP

  == domain 2  score: 20.3 bits;  conditional E-value: 1.2e-07
       EGF_2   5 deiCgghGtCvnqcGqCdCdsgyqGktC 32 
                 +  C+g+G+C +++ +C C+ gy G +C
  EFC39929.1 259 SKVCSGNGICQSFN-NCACKVGYMGSDC 285
                 568********999.8************ PP

>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.9   8.5e+03      13      26 ..      93     106 ..      92     107 .. 0.77
   2 ?    2.4   0.0      0.04   1.8e+02       4      20 ..     144     160 ..     141     167 .. 0.84
   3 !   10.9   0.0   8.5e-05      0.38       1      26 [.     198     223 ..     198     223 .. 0.96

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.9
                 TEEEEEECCCTEEE CS
         NHL  13 GdiyVaDsenhrvq 26 
                 ++++ aD+ n+r++
  EFC39929.1  93 NELVFADTINFRIR 106
                 66777999999997 PP

  == domain 2  score: 2.4 bits;  conditional E-value: 0.04
                 EEEEEEETTTEEEEEEC CS
         NHL   4 PhGvavdsnGdiyVaDs 20 
                 P++va +snG+ ++a++
  EFC39929.1 144 PASVAFLSNGEMIIAER 160
                 99*********999986 PP

  == domain 3  score: 10.9 bits;  conditional E-value: 8.5e-05
                 BSSEEEEEEETTTEEEEEECCCTEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvq 26 
                 +n+P +++v+++++i+  D++n+r++
  EFC39929.1 198 LNDPLSLTVLKGDRILFVDRGNNRIR 223
                 799*********************96 PP

>> EGF  EGF-like domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    1.6   0.2     0.081   3.6e+02       5      13 ..     242     252 ..     239     258 .. 0.80
   2 ?    7.4   4.1    0.0012       5.3       6      30 ..     262     282 ..     257     284 .. 0.80

  Alignments for each domain:
  == domain 1  score: 1.6 bits;  conditional E-value: 0.081
                 T..STTT-EEE CS
         EGF   5 p..CsngGtCv 13 
                    Csn+ tC+
  EFC39929.1 242 GmiCSNQTTCF 252
                 455*******5 PP

  == domain 2  score: 7.4 bits;  conditional E-value: 0.0012
                 STTT-EEEEETTTEEEEEECTTEES CS
         EGF   6 CsngGtCvdtgrggytCiCpeGytG 30 
                 Cs++G+C        +C C++Gy G
  EFC39929.1 262 CSGNGICQ----SFNNCACKVGYMG 282
                 *******4....555********77 PP

>> hEGF  Human growth factor-like EGF
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.6     0.048   2.1e+02       1      13 [.     245     253 ..     245     255 .. 0.88
   2 ?    7.5   7.2    0.0014       6.5       1      22 []     262     280 ..     262     280 .. 0.91

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.048
                 --TT-EES..-SS CS
        hEGF   1 CnngGtCidgvgg 13 
                 C+n +tC+    g
  EFC39929.1 245 CSNQTTCF----G 253
                 *******9....4 PP

  == domain 2  score: 7.5 bits;  conditional E-value: 0.0014
                 --TT-EES..-SS..-EE--TTX CS
        hEGF   1 CnngGtCidgvgg.ykCiCpPGy 22 
                 C+++G+C+    + + C C+ Gy
  EFC39929.1 262 CSGNGICQ----SfNNCACKVGY 280
                 ********....5588******9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (524 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1016  (0.056668); expected 358.6 (0.02)
Passed bias filter:                      594  (0.0331307); expected 358.6 (0.02)
Passed Vit filter:                        64  (0.00356964); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.70u 0.34s 00:00:01.04 Elapsed: 00:00:00.53
# Mc/sec: 2984.78
//
Query:       EFC39930.1  [L=747]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model        Description
    ------- ------ -----    ------- ------ -----   ---- --  --------     -----------
    1.3e-39  132.3   7.8    5.2e-05   23.1   0.0   10.8 11  NHL           NHL repeat
    6.4e-06   25.9   0.3        1.8    8.1   0.0    4.8  4  SGL           SMP-30/Gluconolactonase/LRE-like region
  ------ inclusion threshold ------
       0.56   10.4   8.0         25    5.2   0.0    5.0  6  Arylesterase  Arylesterase


Domain annotation for each model (and alignments):
>> NHL  NHL repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.0   0.0   0.00026       1.5       3      26 ..      57      81 ..      55      81 .. 0.93
   2 !   11.4   0.0   4.4e-05      0.26       3      20 ..     115     132 ..     113     135 .. 0.88
   3 !   18.4   0.3   2.7e-07    0.0016       1      27 [.     171     197 ..     171     198 .. 0.95
   4 !   11.7   0.0   3.5e-05      0.21       4      19 ..     269     284 ..     268     291 .. 0.88
   5 !    6.1   0.0     0.002        12      14      27 ..     335     348 ..     323     349 .. 0.84
   6 !    8.1   0.1   0.00049       2.9      11      25 ..     391     405 ..     388     407 .. 0.86
   7 !   16.1   0.0   1.4e-06    0.0084       1      27 [.     499     525 ..     499     526 .. 0.94
   8 !   23.1   0.0   8.7e-09   5.2e-05       6      28 .]     559     581 ..     554     581 .. 0.94
   9 !   19.9   0.0   8.9e-08   0.00053       1      23 [.     610     633 ..     610     638 .. 0.92
  10 ?   -0.1   0.0      0.19   1.1e+03      12      27 ..     679     694 ..     670     695 .. 0.84
  11 ?   -2.9   0.0       1.5   8.9e+03       7      18 ..     731     742 ..     730     742 .. 0.85

  Alignments for each domain:
  == domain 1  score: 9.0 bits;  conditional E-value: 0.00026
                SEEEEEEE.TTTEEEEEECCCTEEE CS
         NHL  3 yPhGvavd.snGdiyVaDsenhrvq 26
                +P Gvav+  nG++y +D +nh+v+
  EFC39930.1 57 FPLGVAVSpLNGNVYFSDMYNHQVR 81
                8*******99************995 PP

  == domain 2  score: 11.4 bits;  conditional E-value: 4.4e-05
                 SEEEEEEETTTEEEEEEC CS
         NHL   3 yPhGvavdsnGdiyVaDs 20 
                  P++va++snG++y+a++
  EFC39930.1 115 TPSSVALNSNGELYIAEY 132
                 69**************86 PP

  == domain 3  score: 18.4 bits;  conditional E-value: 2.7e-07
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P++v+ +snGd++++D++n r+++
  EFC39930.1 171 LNQPRCVVPVSNGDVFICDTYNYRIRK 197
                 79***********************86 PP

  == domain 4  score: 11.7 bits;  conditional E-value: 3.5e-05
                 EEEEEEETTTEEEEEE CS
         NHL   4 PhGvavdsnGdiyVaD 19 
                 P G++ dsnGd+yVa+
  EFC39930.1 269 PKGIVFDSNGDLYVAE 284
                 99*************8 PP

  == domain 5  score: 6.1 bits;  conditional E-value: 0.002
                 EEEEEECCCTEEEE CS
         NHL  14 diyVaDsenhrvqv 27 
                  +y+aD  n+r+++
  EFC39930.1 335 KLYIADASNNRIRH 348
                 79**********86 PP

  == domain 6  score: 8.1 bits;  conditional E-value: 0.00049
                 TTTEEEEEECCCTEE CS
         NHL  11 snGdiyVaDsenhrv 25 
                 +++++++aD++n rv
  EFC39930.1 391 QTDELLIADTNNYRV 405
                 899***********9 PP

  == domain 7  score: 16.1 bits;  conditional E-value: 1.4e-06
                 BSSEEEEEEETTTEEEEEECCCTEEEE CS
         NHL   1 fnyPhGvavdsnGdiyVaDsenhrvqv 27 
                 +n+P+G+a   nGd+y++Ds nh +++
  EFC39930.1 499 LNEPAGLAFAINGDLYICDSINHAIRK 525
                 799********************9986 PP

  == domain 8  score: 23.1 bits;  conditional E-value: 8.7e-09
                 EEEEETTTEEEEEECCCTEEEEE CS
         NHL   6 GvavdsnGdiyVaDsenhrvqvF 28 
                 G++v++nGd+++aD++n+r++++
  EFC39930.1 559 GLSVLPNGDLLIADYNNNRIRKY 581
                 99******************997 PP

  == domain 9  score: 19.9 bits;  conditional E-value: 8.9e-08
                 BSSEEEEEEE.TTTEEEEEECCCT CS
         NHL   1 fnyPhGvavd.snGdiyVaDsenh 23 
                 +n+P++va++ s+Gd+++aD++n 
  EFC39930.1 610 LNHPTDVAYNaSTGDVFIADFGNK 633
                 79*******************996 PP

  == domain 10  score: -0.1 bits;  conditional E-value: 0.19
                 TTEEEEEECCCTEEEE CS
         NHL  12 nGdiyVaDsenhrvqv 27 
                 +G+++++Ds n  +++
  EFC39930.1 679 TGELFISDSVNYLIRK 694
                 69*******9988875 PP

  == domain 11  score: -2.9 bits;  conditional E-value: 1.5
                 EEEETTTEEEEE CS
         NHL   7 vavdsnGdiyVa 18 
                 ++ ++ Gd+++a
  EFC39930.1 731 ITFSPKGDLFIA 742
                 67889****997 PP

>> SGL  SMP-30/Gluconolactonase/LRE-like region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    4.6   0.0    0.0034        20     129     202 ..      51     132 ..      28     152 .. 0.70
   2 !    8.1   0.0   0.00031       1.8      11      78 ..     238     304 ..     227     321 .. 0.80
   3 !    6.1   0.1    0.0012         7      96     210 ..     456     581 ..     328     594 .. 0.56
   4 ?   -1.4   0.0      0.24   1.4e+03     192     213 ..     620     641 ..     559     651 .. 0.65

  Alignments for each domain:
  == domain 1  score: 4.6 bits;  conditional E-value: 0.0034
         SGL 129 vlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge........gepDGlavDaeGnvwvAvw 202
                 ++ ++t+p G+a+sp +  +Y+ D  ++++  +d +  +       ++a ++            +p ++a+ ++G++++A +
  EFC39930.1  51 TQVGMTFPLGVAVSPLNGNVYFSDMYNHQVRYVDSNGFSHLAAGSPTLAAGESSYftlandtlLTPSSVALNSNGELYIAEY 132
                 5566777778888888888888888777777777766666555555555555555666666555577777777777777755 PP

  == domain 2  score: 8.1 bits;  conditional E-value: 0.00031
         SGL  11 egaLlwvDilgqrihrldpatgketvldtpesvGaiaprkdgrlvvasksglalldlasgeletlade 78 
                 +g+++++D  ++ i  + +++  +t+++  ++ G++++  +g l+va+++   ++++++g  +++a +
  EFC39930.1 238 SGEMYFSDFDNNAIKYIANNGSVYTYVSSFGPKGIVFD-SNGDLYVAEATYDQIVKFSNGVRTVIANN 304
                 67889999999999999988888888888889999999.88999999988888888888777777665 PP

  == domain 3  score: 6.1 bits;  conditional E-value: 0.0012
         SGL  96 dGrlwfGtmgdeeakgeev.......galyrldpdgklervlddltipNGlawspdgktlYlaDsltrkiwaydvdaeggklsnrrvfadlkkge.... 183
                  G +++Gt  +  + +++        g++  l +d   + ++++l+ p Gla+   g+ lY++Ds ++ i ++d ++      +   +a +k+g+    
  EFC39930.1 456 SGDVFIGTTFKILKVSKKDkrvstvaGSVSTLAGD-NFNSIASQLNEPAGLAFAINGD-LYICDSINHAIRKIDHETGIISTIAGNGIAGFKDGNasia 552
                 56666665433332222223567777888888887.8888889999999999988775.7889999999998888654444444555566666666665 PP

         SGL 184 ..gepDGlavDaeGnvwvAvwgggkvvrf 210
                   +   Gl v  +G + +A +++++++++
  EFC39930.1 553 qfNSNLGLSVLPNGDLLIADYNNNRIRKY 581
                 55334466666666666666666666665 PP

  == domain 4  score: -1.4 bits;  conditional E-value: 0.24
         SGL 192 DaeGnvwvAvwgggkvvrfdpd 213
                  ++G v++A +g++ ++++++ 
  EFC39930.1 620 ASTGDVFIADFGNKVIRKISNS 641
                 3477777777777777777776 PP

>> Arylesterase  Arylesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    5.2   0.0    0.0042        25      46      78 ..      48      80 ..      41      86 .. 0.87
   2 ?    1.9   0.2     0.045   2.7e+02      47      78 ..     261     290 ..     234     296 .. 0.70
   3 ?   -2.6   0.0       1.1   6.5e+03      65      78 ..     333     346 ..     324     352 .. 0.79
   4 ?    2.5   0.0     0.029   1.7e+02      30      79 ..     476     524 ..     464     530 .. 0.84
   5 ?    0.8   0.0     0.093   5.6e+02      34      77 ..     591     634 ..     578     641 .. 0.80
   6 ?   -3.2   0.0       1.7     1e+04      54      78 ..     668     692 ..     659     699 .. 0.79

  Alignments for each domain:
  == domain 1  score: 5.2 bits;  conditional E-value: 0.0042
  Arylesterase 46 vkvvasglssanGInidadkkyiyvadilresi 78
                  vk    g++++ G+ +++ +  +y +d+ ++++
    EFC39930.1 48 VKATQVGMTFPLGVAVSPLNGNVYFSDMYNHQV 80
                  67777899**********************998 PP

  == domain 2  score: 1.9 bits;  conditional E-value: 0.045
  Arylesterase  47 kvvasglssanGInidadkkyiyvadilresi 78 
                    + +s++  + GI++d++   +yva+ + ++i
    EFC39930.1 261 YTYVSSF-GPKGIVFDSNGD-LYVAEATYDQI 290
                   3444444.499*****9875.8****999888 PP

  == domain 3  score: -2.6 bits;  conditional E-value: 1.1
  Arylesterase  65 kkyiyvadilresi 78 
                    k +y+ad  ++ i
    EFC39930.1 333 GKKLYIADASNNRI 346
                   6899****999888 PP

  == domain 4  score: 2.5 bits;  conditional E-value: 0.029
  Arylesterase  30 slqlawtavvYyspsevkvvasglssanGInidadkkyiyvadilresih 79 
                   ++ +  ++v    +++ +  as+l+ + G+ +  +   +y+ d++++ i 
    EFC39930.1 476 RVSTVAGSVSTLAGDNFNSIASQLNEPAGLAFAING-DLYICDSINHAIR 524
                   5677777888888999999***********998766.68*******9985 PP

  == domain 5  score: 0.8 bits;  conditional E-value: 0.093
  Arylesterase  34 awtavvYyspsevkvvasglssanGInidadkkyiyvadilres 77 
                   + ++   ys++      ++l+ ++ + ++a    +++ad  ++ 
    EFC39930.1 591 IAGGLAGYSGDGQLATSAQLNHPTDVAYNASTGDVFIADFGNKV 634
                   55666668888888888899******************986655 PP

  == domain 6  score: -3.2 bits;  conditional E-value: 1.7
  Arylesterase  54 ssanGInidadkkyiyvadilresi 78 
                   +s+ G+ i +    ++++d+++  i
    EFC39930.1 668 ISPYGLSIHPITGELFISDSVNYLI 692
                   6789999999999999999987655 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (747 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       441  (0.024597); expected 358.6 (0.02)
Passed bias filter:                      303  (0.0169); expected 358.6 (0.02)
Passed Vit filter:                        19  (0.00105974); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.66u 0.31s 00:00:00.97 Elapsed: 00:00:00.50
# Mc/sec: 4505.96
//
Query:       EFC39931.1  [L=943]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    8.2e-08   33.0   0.0    1.7e-07   32.1   0.0    1.5  1  2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily


Domain annotation for each model (and alignments):
>> 2OG-FeII_Oxy_3  2OG-Fe(II) oxygenase superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.1   0.0   9.3e-12   1.7e-07       2      93 ..     182     268 ..     181     271 .. 0.75

  Alignments for each domain:
  == domain 1  score: 32.1 bits;  conditional E-value: 9.3e-12
                     EEEEE-TT-EEEEE-SS----TT.-.EEEEEEEEE....ET-B--EEE..............---TT-E....EEEE-..B-TEEE--B.-SS-E CS
  2OG-FeII_Oxy_3   2 qvlrygegqeykpHvDnfekeegsgqrrltvllyLnekeseeGGelelyekdk....eavkikpkkgrl....vlFesdellpHevlpvtkggeR 88 
                     ++l y+eg++++ H D+    e+++ +++t+++ L  ++s++GGe+++++k+k    ++ +       +    v F++d    H+v+ v++ g R
      EFC39931.1 182 KMLLYEEGGFFDFHRDT----EKENGMIATLVVQL--PSSFTGGEIVVRHKEKeniyKTSED-AT---FnpyyVSFYCDVS--HKVETVKS-GYR 263
                     6789************7....44578*********..578********87777654322222.23...1444599999766..******66.59* PP

                     EEEEE CS
  2OG-FeII_Oxy_3  89 lsltg 93 
                     l+l +
      EFC39931.1 264 LALIY 268
                     99876 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (943 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       890  (0.0496402); expected 358.6 (0.02)
Passed bias filter:                      477  (0.0266049); expected 358.6 (0.02)
Passed Vit filter:                        33  (0.00184059); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.80u 0.29s 00:00:01.09 Elapsed: 00:00:00.50
# Mc/sec: 5699.82
//
Query:       EFC39932.1  [L=1232]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (1232 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       755  (0.0421105); expected 358.6 (0.02)
Passed bias filter:                      316  (0.0176251); expected 358.6 (0.02)
Passed Vit filter:                        24  (0.00133861); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.81u 0.31s 00:00:01.12 Elapsed: 00:00:00.52
# Mc/sec: 7188.84
//
Query:       EFC39933.1  [L=110]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    1.6e-10   41.7   0.0    1.8e-10   41.5   0.0    1.0  1  Lipase_GDSL_2  GDSL-like Lipase/Acylhydrolase family
    0.00015   21.8   0.0    0.00017   21.6   0.0    1.1  1  Lipase_GDSL    GDSL-like Lipase/Acylhydrolase


Domain annotation for each model (and alignments):
>> Lipase_GDSL_2  GDSL-like Lipase/Acylhydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   41.5   0.0     2e-14   1.8e-10       1      94 [.      10     100 ..      10     107 .. 0.72

  Alignments for each domain:
  == domain 1  score: 41.5 bits;  conditional E-value: 2e-14
                    EEESHHHHTCTTBCCHCHHCCCCCCCHHHTT-EEEEE..EEHCCH-H..HHHHHHHHCTGGG-T....SEEEEE--CCCCCTT--HHHHHHH..HH CS
  Lipase_GDSL_2   1 alGDSiTaGygadgggrsypaylarllaarlgldvvnn.lgvsGattallrllerlrdllrlkp....dlvtiliGtNDlgrgvpaaaaaandnle 91 
                    alGDS+T Gy   ++g sy+ y a++l+  l +++++  +g +G+ t  +++ erl++ l++ +    + v+i  GtNDl+   ++    +n  l 
     EFC39933.1  10 ALGDSLTKGYY--NNGFSYHPY-ANRLSFLLTNKYHVEpFGENGEET--QEMKERLDQILDYYAkdafKGVIIIGGTNDLASYSSDMI-IEN--LI 97 
                    79********9..666777777.7777777766667777********..999999995555555544556*********976655543.334..55 PP

                    HHH CS
  Lipase_GDSL_2  92 eli 94 
                     ++
     EFC39933.1  98 GMY 100
                    555 PP

>> Lipase_GDSL  GDSL-like Lipase/Acylhydrolase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.6   0.0   1.9e-08   0.00017       1      95 [.       8      88 ..       8     105 .. 0.70

  Alignments for each domain:
  == domain 1  score: 21.6 bits;  conditional E-value: 1.9e-08
                 EEEEESHHHHTTTHHHHHHHCCCCEECCCTTC.GCEEEEEEECTTHHHHHHHCCH..ECTTTECHHHHHCTTSEEEEE--CTCC-EECSSCTTTCEE CS
                 xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx..xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RF
  Lipase_GDSL  1 ivafGDSltdGdgaatlntiqlktpknlnefdlaldrianignkgasdnelqqll..nkyplkseqlkalhpdlviislGtNDsnlgkkstdaakke 95
                 i+a+GDSlt G+  + ++     ++ +++ ++ ++  ++  +  + + ++++ ++  ++y +++       ++ vii  GtND+         a ++
   EFC39933.1  8 ILALGDSLTKGYYNNGFSYHPYANRLSFLLTNKYHVEPFGENGEETQEMKERLDQilDYYAKDA-------FKGVIIIGGTNDL---------ASYS 88
                 89**********8888888888888887777555555555555555555555444666666666.......779**********.........3333 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (110 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       480  (0.0267723); expected 358.6 (0.02)
Passed bias filter:                      431  (0.0240393); expected 358.6 (0.02)
Passed Vit filter:                        39  (0.00217525); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.49u 0.32s 00:00:00.81 Elapsed: 00:00:00.49
# Mc/sec: 671.82
//
Query:       EFC39934.1  [L=223]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model     Description
    ------- ------ -----    ------- ------ -----   ---- --  --------  -----------
    2.5e-44  149.1   3.6      6e-23   80.6   0.0    3.0  3  Mito_carr  Mitochondrial carrier protein


Domain annotation for each model (and alignments):
>> Mito_carr  Mitochondrial carrier protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    9.6   0.1   4.6e-05      0.82      70      95 ..       2      27 ..       1      29 [. 0.91
   2 !   80.6   0.0   3.4e-27     6e-23       5      91 ..      38     122 ..      36     127 .. 0.95
   3 !   58.8   0.3   2.2e-20   3.9e-16       6      93 ..     136     223 .]     133     223 .] 0.91

  Alignments for each domain:
  == domain 1  score: 9.6 bits;  conditional E-value: 4.6e-05
                HHHHHHHHHHHHHHHHHHHHHHHHCT CS
   Mito_carr 70 pnllrvapasalkfvlyetlkrlllk 95
                 n+ r++p++a +f++ + lk+++ +
  EFC39934.1  2 TNIYRYFPTQAFNFSFKDALKKMFPD 27
                699********************976 PP

  == domain 2  score: 80.6 bits;  conditional E-value: 3.4e-27
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSSHHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   5 vlkellaGglagavatlvttPldvvKtrlqtqkksskksksaaildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkr 91 
                 +l +l++Gglaga++ ++++Pld+++trl ++ +++++  ++++ d++ k+yk+ G+r+ly G+++++ +++p+++++f+ly+tl++
  EFC39934.1  38 FLVQLASGGLAGAGSLCIVYPLDYARTRLASDVGNHRD--FNGLGDCMVKTYKQGGFRALYNGFGVSVAGIIPYRGVYFGLYDTLRE 122
                 67899*****************************9887..778*****************************************987 PP

  == domain 3  score: 58.8 bits;  conditional E-value: 2.2e-20
                 HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCSSTTTSCSS.HHHHHHHHHHHHHHHGGGTTHHHHHHHHHHHHHHHHHHHHHHHHHH CS
   Mito_carr   6 lkellaGglagavatlvttPldvvKtrlqtqkksskksksaa.ildvlkkiykeeGlrglyrGllpnllrvapasalkfvlyetlkrll 93 
                  ++++ + +  ++a+ + +P+d+v+ rl++q+++ +++  +  ++d+++ki+keeG  ++++G+++n lr++  sal +vly++++ ++
  EFC39934.1 136 SSKFALAQTVSIAAGYASYPFDTVRRRLMMQSEKPREQWVYTgTVDCFSKILKEEGTVAMFKGAGANALRTV-GSALVLVLYDQMQGMF 223
                 567888889999**********************988766557*****************************.***********99775 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (223 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       261  (0.0145574); expected 358.6 (0.02)
Passed bias filter:                      230  (0.0128284); expected 358.6 (0.02)
Passed Vit filter:                        15  (0.000836633); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.58u 0.32s 00:00:00.89 Elapsed: 00:00:00.55
# Mc/sec: 1229.07
//
Query:       EFC39935.1  [L=130]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
      0.082   12.2   0.0       0.14   11.5   0.0    1.3  1  ThiF      ThiF family


Domain annotation for each model (and alignments):
>> ThiF  ThiF family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.5   0.0   7.8e-06      0.14      30      70 ..      65     109 ..      64     116 .. 0.89

  Alignments for each domain:
  == domain 1  score: 11.5 bits;  conditional E-value: 7.8e-06
                 HHHHHHHHHHHTTT....EEEEEESSB--GGGGGTBTTS-GGGTT CS
                 xxxxxxxxxxxxxx....xxxxxxxxxxxxxxxxxxxxxxxxxxx RF
        ThiF  30 GsellknLalsGvg....kltlvDnDkielsNlnRqflfreediG 70 
                 G + l +L ++ +     ++  +D D   +s +nR++lf++++iG
  EFC39935.1  65 GRWTLGYLTRADIAyrkkQIMKIDPDYWFKSSPNRWILFKRSSIG 109
                 6677888888888777889999**********************9 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (130 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       403  (0.0224776); expected 358.6 (0.02)
Passed bias filter:                      332  (0.0185175); expected 358.6 (0.02)
Passed Vit filter:                        20  (0.00111551); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.42u 0.28s 00:00:00.70 Elapsed: 00:00:00.44
# Mc/sec: 890.93
//
Query:       EFC39936.1  [L=539]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------

   [No hits detected that satisfy reporting thresholds]


Domain annotation for each model (and alignments):

   [No targets detected that satisfy reporting thresholds]


Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (539 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       980  (0.05466); expected 358.6 (0.02)
Passed bias filter:                      495  (0.0276089); expected 358.6 (0.02)
Passed Vit filter:                        36  (0.00200792); expected 17.9 (0.001)
Passed Fwd filter:                         0  (0); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               0  [number of targets reported over threshold]
# CPU time: 0.67u 0.31s 00:00:00.98 Elapsed: 00:00:00.52
# Mc/sec: 3130.92
//
Query:       EFC39937.1  [L=482]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    6.2e-51  169.9  10.4    5.4e-17   61.3   0.0    7.5  8  DUF4116          Domain of unknown function (DUF4116)
  ------ inclusion threshold ------
       0.11   12.7   0.0       0.22   11.8   0.0    1.4  1  Herpes_heli_pri  Herpesvirus helicase-primase complex compone
       0.67   10.5   4.6       0.51   10.8   0.1    2.8  3  Pep1_7           Elicitor peptide 1-7


Domain annotation for each model (and alignments):
>> DUF4116  Domain of unknown function (DUF4116)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.3   0.0      0.66   3.9e+03      27      32 ..      78      83 ..      64     101 .. 0.48
   2 !   25.5   0.0   1.3e-09   7.7e-06       5      39 ..     149     183 ..     145     210 .. 0.79
   3 ?    0.2   0.0       0.1   6.3e+02      15      43 ..     201     227 ..     189     227 .. 0.80
   4 !   26.5   0.0   6.5e-10   3.9e-06       4      41 ..     305     342 ..     303     342 .. 0.96
   5 !   61.3   0.0     9e-21   5.4e-17       1      49 []     327     375 ..     327     375 .. 0.99
   6 !   42.9   0.0   4.8e-15   2.8e-11       1      45 [.     377     422 ..     377     426 .. 0.95
   7 !   36.4   0.1   5.2e-13   3.1e-09       3      46 ..     405     448 ..     405     451 .. 0.95
   8 !   17.4   0.4   4.5e-07    0.0027       2      34 ..     429     462 ..     428     472 .. 0.90

  Alignments for each domain:
  == domain 1  score: -2.3 bits;  conditional E-value: 0.66
     DUF4116 27 keivlk 32
                +e++ +
  EFC39937.1 78 REFAFE 83
                233333 PP

  == domain 2  score: 25.5 bits;  conditional E-value: 1.3e-09
     DUF4116   5 vleavkkngsalkylseeLknDkeivlkAvkqngt 39 
                 +l av+++g+al+++s+eL+ D ++v++A+ ++ +
  EFC39937.1 149 ALAAVSTCGLALEFASKELRDDVDVVIAAMYSDAF 183
                 799***************************99875 PP

  == domain 3  score: 0.2 bits;  conditional E-value: 0.1
     DUF4116  15 alkylseeLknDkeivlkAvkqngtalsy 43 
                 a+ ++s +Lk  ke+   A++++g+++++
  EFC39937.1 201 AYDFASLRLK--KELHSVAINIYGDFFRF 227
                 7889998887..89999999999998876 PP

  == domain 4  score: 26.5 bits;  conditional E-value: 6.5e-10
     DUF4116   4 ivleavkkngsalkylseeLknDkeivlkAvkqngtal 41 
                 iv+e+v   +++lk+ see+k D eiv  Av++ng al
  EFC39937.1 305 IVKECVGYSPLSLKNTSEEFKDDEEIVRIAVEKNGLAL 342
                 9**********************************886 PP

  == domain 5  score: 61.3 bits;  conditional E-value: 9e-21
     DUF4116   1 DrEivleavkkngsalkylseeLknDkeivlkAvkqngtalsyaseeLr 49 
                 D+Eiv  av+kng+al+++s++Lkn kei++ Av++ng+al+++++eL+
  EFC39937.1 327 DEEIVRIAVEKNGLALQFASDRLKNKKEIAKIAVRWNGDALKFVPKELQ 375
                 9**********************************************97 PP

  == domain 6  score: 42.9 bits;  conditional E-value: 4.8e-15
     DUF4116   1 DrEivleavkkn.gsalkylseeLknDkeivlkAvkqngtalsyas 45 
                 D +ivl av+   g+a+++++ +L+n+kei+l+ vk+n+ ++++as
  EFC39937.1 377 DFDIVLDAVTFPsGNAIEHVPISLRNNKEIMLASVKSNPESIKFAS 422
                 88**********99*******************************9 PP

  == domain 7  score: 36.4 bits;  conditional E-value: 5.2e-13
     DUF4116   3 EivleavkkngsalkylseeLknDkeivlkAvkqngtalsyase 46 
                 Ei+l  vk+n++++k++s  L+nD ++v++Av + g+ l+++ +
  EFC39937.1 405 EIMLASVKSNPESIKFASYVLRNDYDVVKEAVYRRGSLLEFVED 448
                 9****************************************976 PP

  == domain 8  score: 17.4 bits;  conditional E-value: 4.5e-07
     DUF4116   2 rEivleavkkngsalkyl.seeLknDkeivlkAv 34 
                  ++v+eav + gs l+++ ++ ++nDk+i++ A+
  EFC39937.1 429 YDVVKEAVYRRGSLLEFVeDPLIRNDKDIIIIAC 462
                 599**************768999********998 PP

>> Herpes_heli_pri  Herpesvirus helicase-primase complex component
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.8   0.0   3.6e-05      0.22      74     115 ..      41      82 ..       9      91 .. 0.82

  Alignments for each domain:
  == domain 1  score: 11.8 bits;  conditional E-value: 3.6e-05
  Herpes_heli_pri  74 GPlcyraklsvPvdvnYaeYlekiltavekvseletnkemtl 115
                       P+  ++  +vP +v Y+  ++ il+a+ek  + + ++e+ +
       EFC39937.1  41 SPILMQQIRDVPKNVKYELIIHPILKAFEKCNQDNDEREFAF 82 
                      488899999**********************99999887654 PP

>> Pep1_7  Elicitor peptide 1-7
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.2   0.0         1   6.1e+03      22      32 ..      61      71 ..      59      72 .. 0.90
   2 ?   10.8   0.1   8.5e-05      0.51      19      71 ..     295     347 ..     291     354 .. 0.75
   3 ?   -0.6   0.1      0.31   1.9e+03      13      27 ..     463     477 ..     460     478 .. 0.83

  Alignments for each domain:
  == domain 1  score: -2.2 bits;  conditional E-value: 1
      Pep1_7 22 ihqilraflkc 32
                ih il+af kc
  EFC39937.1 61 IHPILKAFEKC 71
                899*****999 PP

  == domain 2  score: 10.8 bits;  conditional E-value: 8.5e-05
      Pep1_7  19 fsfihqilrafl.kclGLesssskspsssseeeeeetetvevtsrglvakvlkr 71 
                 +++ ++ lra++ +c G+ s+ s ++ s++ +++ee     v+++gl  + ++ 
  EFC39937.1 295 CKLKQEYLRAIVkECVGY-SPLSLKNTSEEFKDDEEIVRIAVEKNGLALQFASD 347
                 99999*******99***8.55555565777777899889999999998884433 PP

  == domain 3  score: -0.6 bits;  conditional E-value: 0.31
      Pep1_7  13 yylwipfsfihqilr 27 
                  +l +pf +i++ ++
  EFC39937.1 463 LSLESPFRCIQDLFQ 477
                 56889******9986 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (482 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       734  (0.0409393); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        34  (0.00189637); expected 17.9 (0.001)
Passed Fwd filter:                         3  (0.000167327); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.64u 0.32s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2811.22
//
Query:       EFC39938.1  [L=629]
Description: pescadillo family protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
    2.7e-88  296.1   7.1    2.7e-88  296.1   7.1    2.1  2  Pescadillo_N    Pescadillo N-terminus
      1e-06   29.0   3.0    1.1e-06   28.9   0.0    2.6  2  BRCT_2          BRCT domain, a BRCA1 C-terminus domain
  ------ inclusion threshold ------
       0.69    9.8   3.0       0.48   10.3   0.4    2.0  2  PS_pyruv_trans  Polysaccharide pyruvyl transferase


Domain annotation for each model (and alignments):
>> Pescadillo_N  Pescadillo N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  296.1   7.1   4.5e-92   2.7e-88       7     251 ..      16     263 ..      11     279 .. 0.94
   2 ?   -5.0   4.0       2.8   1.7e+04      85     115 ..     508     538 ..     482     558 .. 0.60

  Alignments for each domain:
  == domain 1  score: 296.1 bits;  conditional E-value: 4.5e-92
  Pescadillo_N   7 eakkyitrkqalkkLqlslkdFRrLCilKGiyPrepkk..kkkankgstaaktyYyakdikfLlhepilekfreikafakklkkalakkekekakrl 101
                   ++ ky+ ++ a  +Lqls ++FR++ ilKGi+P+ p+k  k k+  + ++ ktyYy+kdi+f++h+p+++k+re+k++ ++++ka+++++ e+ +rl
    EFC39938.1  16 TKVKYLAKNTAQERLQLSRANFRHMLILKGIHPKVPEKnvKAKNATKYAKDKTYYYKKDINFIAHDPLIDKLREYKTYLRRVSKAKGRGDIEHFERL 112
                   6789******************************99994555566667889********************************************** PP

  Pescadillo_N 102 eknkpkykldhiikeRYPtfidAlrdldDaLsliflfatlp.ktkkikekliekcerlaeefqayviksrslrkvFlSiKGiYyqaeikgqkvtWlv 197
                   ++ +p+ + dh++keRYP+f+ Al+dl+D+L+++f+f++lp    k+++++ e+++rl++ef   v++++slrkvFlS KGiYyqa+++g +vtW+v
    EFC39938.1 113 QELEPEFTYDHLVKERYPSFQAALNDLNDCLCILFMFTQLPaGLGKVTAEMSENAKRLCDEFCSLVCQTNSLRKVFLSFKGIYYQANVQGVDVTWIV 209
                   *****************************************6779**************************************************** PP

  Pescadillo_N 198 PykfaqklekdvdfkvmltflefYetllkfvnfkLykslnlkyppkldeekdek 251
                   Py+f q +++++df+++ +f++fY tll f+n+kLy + n++ypp+  +++d++
    EFC39938.1 210 PYDFPQVIPENIDFNIFRSFMQFYITLLTFINYKLYFDNNMEYPPNYTTKNDKS 263
                   **********************************************88777664 PP

  == domain 2  score: -5.0 bits;  conditional E-value: 2.8
  Pescadillo_N  85 klkkalakkekekakrleknkpkykldhiik 115
                   k kk+++++e+ ++++l +++ k kl + ik
    EFC39938.1 508 KNKKEEKEQEQIEMRKLMASRKKRKLYEYIK 538
                   3333333344444455555555555555444 PP

>> BRCT_2  BRCT domain, a BRCA1 C-terminus domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.0   1.8       1.7     1e+04       3      12 ..     224     234 ..     223     250 .. 0.82
   2 !   28.9   0.0   1.9e-10   1.1e-06       3      84 ..     309     395 ..     307     396 .. 0.78

  Alignments for each domain:
  == domain 1  score: -3.0 bits;  conditional E-value: 1.7
      BRCT_2   3 klF.eglrFYi 12 
                 ++F + ++FYi
  EFC39938.1 224 NIFrSFMQFYI 234
                 678788***** PP

  == domain 2  score: 28.9 bits;  conditional E-value: 1.9e-10
      BRCT_2   3 klFeglrFYindaepspsreklkklIeknGGev....veti......tsavyiviaesneeelaekrkrrvvspkyIkdCikkgkllpleny 84 
                 + F+g+ FY      +  ++ l+ +++++GGe+    +          ++ +++++ ++   ++  ++r++v+p+y++d++++   lp+e+y
  EFC39938.1 309 GMFKGMVFYF---SRECPKASLEFIVKSFGGECgwasE--DspfdetYDKITHMVVDRKVPAEKMIKDREYVQPQYLFDSVNAMIKLPVEPY 395
                 68********...445579**************66551..0344444445555555555555899999**********************99 PP

>> PS_pyruv_trans  Polysaccharide pyruvyl transferase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.1      0.76   4.5e+03     191     224 ..      73     107 ..      42     143 .. 0.50
   2 ?   10.3   0.4   8.1e-05      0.48     172     231 ..     516     587 ..     500     609 .. 0.82

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.76
                     ---SSS---HH........................ CS
  PS_pyruv_trans 191 leellakvydllle.kgarllllpivkkdgleldd 224
                     ++ ++++ + l+++ ++++ +l  ++k +g ++++
      EFC39938.1  73 KDINFIAHDPLIDKlREYKTYLRRVSKAKGRGDIE 107
                     22222223333334444444444444444444444 PP

  == domain 2  score: 10.3 bits;  conditional E-value: 8.1e-05
                     -............------------SS--EE---SSS---HH.............................. CS
  PS_pyruv_trans 172 t............dkrkylrvakssekdledleellakvydlllekgarllllpivkkdglelddlyllllr 231
                     +             krk+++++k+ ++++++++++l+++  +l+++ga++     +++ ++++++++++++ 
      EFC39938.1 516 QeqiemrklmasrKKRKLYEYIKKLQRGKNAYNRQLLQRRMKLDKEGASIEEGETEETMQDDVEEEITRKSA 587
                     155556667777779*************************************************99998764 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (629 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2879  (0.160578); expected 358.6 (0.02)
Passed bias filter:                      544  (0.0303419); expected 358.6 (0.02)
Passed Vit filter:                        86  (0.0047967); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               3  [number of targets reported over threshold]
# CPU time: 0.88u 0.33s 00:00:01.21 Elapsed: 00:00:00.53
# Mc/sec: 3564.21
//
Query:       EFC39939.1  [L=241]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    3.5e-10   39.9  19.6    7.2e-09   35.6  16.7    2.4  2  BCAS2          Breast carcinoma amplified sequence 2 (BCAS2)
  ------ inclusion threshold ------
      0.034   14.5   1.4       0.08   13.3   1.4    1.8  1  Thioredoxin_8  Thioredoxin-like
       0.91    9.7  26.0       0.11   12.7   1.7    2.3  2  Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
        1.8    7.9   6.7        3.2    7.0   6.7    1.4  1  DUF4407        Domain of unknown function (DUF4407)
        5.4    7.5  15.4       0.16   12.4   4.3    2.9  3  DUF2681        Protein of unknown function (DUF2681)


Domain annotation for each model (and alignments):
>> BCAS2  Breast carcinoma amplified sequence 2 (BCAS2)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.0       1.1   4.1e+03       2      11 ..       9      18 ..       8      19 .. 0.87
   2 !   35.6  16.7     2e-12   7.2e-09      17     204 ..      57     231 ..      50     234 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 1.1
       BCAS2  2 vvDaLPYiDa 11
                ++DaL Y+D+
  EFC39939.1  9 ILDALSYVDR 18
                78*******7 PP

  == domain 2  score: 35.6 bits;  conditional E-value: 2e-12
       BCAS2  17 elreaveklieeElrrsrkkksdlaelPppkeekl..espllaaeleRveageplealDlsRYeleaPsaekkedleaweealrnakaqlehqalRqeN 113
                  l+++++++i+eE+++ + ++  +++    +e+++  +++ l + ++++ +++++            P  + ++++e++ e++++ +    + +   ++
  EFC39939.1  57 ILKRQIDNMIKEEMKNCEMEEY-HPNTTSSYEPQFsnSTTGLSEHYKQMIEKQEFV-----------PFFS-EKEKEEYLETIKKNEPLYYYHN--CIH 140
                 57999*************9996.999999999999877788888888887777773...........3322.4567788888888777666655..689 PP

       BCAS2 114 leLlekygknaWrvhneqleaelkklekeleetkeeieevnrqRkseQeeageeLksleekWrelvsknleieaaceeleaeieelkrqaa 204
                  eL ++yg+++ r  ne l++++k le+e +++ +eie++n++Rk+eQ +++ eL +l ek ++    + ++ ++c++le   ++lk+ ++
  EFC39939.1 141 TELAKNYGEESLRKANEYLQKQIKLLEREKTQVLQEIENINKKRKREQYDLKYELDKLIEKSTKTNHLIFKLARECTTLESLNKKLKQSRE 231
                 9******************************************************************************999998888765 PP

>> Thioredoxin_8  Thioredoxin-like
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.3   1.4   2.2e-05      0.08      10      79 ..      84     148 ..      81     204 .. 0.92

  Alignments for each domain:
  == domain 1  score: 13.3 bits;  conditional E-value: 2.2e-05
                    -SSSHHHHHHHHHHHHHHHHHHHTTSEEEEEEE-SS-HHHHHHHGGGS-TTSEE.EE-TT-HHHHTT-S- CS
  Thioredoxin_8  10 aswcppckaftpklkelyeklkkkkkveivyvsldkkeeefekylkknkkpwlsvpfddkkrnklkkkyn 79 
                    +s+ p+  + t  l+e y+++    k e+v   + k++ee+ +++kkn      + ++++ + +l+k+y+
     EFC39939.1  84 SSYEPQFSNSTTGLSEHYKQMI--EKQEFVPFFSEKEKEEYLETIKKN---EPLYYYHNCIHTELAKNYG 148
                    6788888999999999999997..89999999999999**********...77779999*********97 PP

>> Jnk-SapK_ap_N  JNK_SAPK-associated protein-1
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.7   1.7   3.1e-05      0.11      39     109 ..      42     112 ..      41     149 .. 0.84
   2 ?    2.2  17.3     0.054   1.9e+02      39     129 ..     150     236 ..     138     241 .] 0.49

  Alignments for each domain:
  == domain 1  score: 12.7 bits;  conditional E-value: 3.1e-05
  Jnk-SapK_ap_N  39 eslasrneeeeaeleelreeleqLeteyerekelrkraeeeleeiedqweeerkelqekveqleeenrele 109
                    +s +s+ e ++ ++e l+++++++ +e ++  e ++ + ++   +e q+ + +  l+e+ +q+ e+++ + 
     EFC39939.1  42 DSSLSKGEYHQFQVEILKRQIDNMIKEEMKNCEMEEYHPNTTSSYEPQFSNSTTGLSEHYKQMIEKQEFVP 112
                    678899999****************************************************9988776554 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.054
  Jnk-SapK_ap_N  39 eslasrneeeeaeleelreeleqLeteyerekelrkraeeeleeiedqweeerkelqekveqleeenrelelkaknaadqlsrleekeael 129
                    esl + ne  + ++++l++e +q  +e e+ +++rkr++ +l    d++ e+  + +  + +l  e+  le    +++++l++  e+++e+
     EFC39939.1 150 ESLRKANEYLQKQIKLLEREKTQVLQEIENINKKRKREQYDLKYELDKLIEKSTKTNHLIFKLARECTTLE----SLNKKLKQSRENKTEE 236
                    34445555555555555555555555555555555555555554444444444455555555555555555....3333333333333333 PP

>> DUF4407  Domain of unknown function (DUF4407)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    7.0   6.7   0.00089       3.2     101     204 ..     132     231 ..     131     241 .] 0.66

  Alignments for each domain:
  == domain 1  score: 7.0 bits;  conditional E-value: 0.00089
     DUF4407 101 LkiFekeIdaelaeeqqeeakelkeqlaaaltaelaeleaqiaalqaeidaaearldalraeaqkeldgtk..gtgtt.gvaGkgpaakekkaqldaaq 196
                 L ++++ I++ela+++ ee  +  ++    l+++++ le++ ++  +ei++ ++++++++ +++ eld     +t+t+  +     +     + l+ ++
  EFC39939.1 132 LYYYHNCIHTELAKNYGEESLRKANE---YLQKQIKLLEREKTQVLQEIENINKKRKREQYDLKYELDKLIekSTKTNhLIFKLARE----CTTLESLN 223
                 56788899999999999998888444...589**********************************996444322211012222222....33333333 PP

     DUF4407 197 aelaelka 204
                 ++l++ ++
  EFC39939.1 224 KKLKQSRE 231
                 33333333 PP

>> DUF2681  Protein of unknown function (DUF2681)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.4   0.2      0.06   2.1e+02      37      70 ..      53      87 ..      32      89 .. 0.77
   2 ?   12.4   4.3   4.4e-05      0.16      29      77 ..     153     201 ..     133     209 .. 0.84
   3 ?   -1.3   0.3      0.83     3e+03      55      69 ..     223     237 ..     210     241 .] 0.61

  Alignments for each domain:
  == domain 1  score: 2.4 bits;  conditional E-value: 0.06
     DUF2681 37 aekqqlkvek.avaeaevknakvkqkneentrrls 70
                 + + lk ++ +++++e+kn ++   + ++t++ +
  EFC39939.1 53 FQVEILKRQIdNMIKEEMKNCEMEEYHPNTTSSYE 87
                56666777762478999***999998888887765 PP

  == domain 2  score: 12.4 bits;  conditional E-value: 4.4e-05
     DUF2681  29 rkknaklqaekqqlkvekavaeaevknakvkqkneentrrlsrdsvddq 77 
                 rk+n+ lq+++  l+ ek++  +e++n ++k+k e+   + + d+++++
  EFC39939.1 153 RKANEYLQKQIKLLEREKTQVLQEIENINKKRKREQYDLKYELDKLIEK 201
                 69********************************998777777777776 PP

  == domain 3  score: -1.3 bits;  conditional E-value: 0.83
     DUF2681  55 nakvkqkneentrrl 69 
                 n k kq  e++t+ +
  EFC39939.1 223 NKKLKQSRENKTEES 237
                 455555555555444 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (241 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2576  (0.143678); expected 358.6 (0.02)
Passed bias filter:                      447  (0.0249317); expected 358.6 (0.02)
Passed Vit filter:                        62  (0.00345808); expected 17.9 (0.001)
Passed Fwd filter:                        10  (0.000557756); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.65u 0.31s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 1399.91
//
Query:       EFC39940.1  [L=931]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.7e-48  164.7   0.0    5.1e-48  163.8   0.0    1.5  1  PGAP1          PGAP1-like protein
    0.00069   19.0   0.0      0.039   13.3   0.0    2.4  2  DUF915         Alpha/beta hydrolase of unknown function (DUF9
    0.00087   18.9   0.0      0.002   17.7   0.0    1.6  1  DUF676         Putative serine esterase (DUF676)
     0.0012   19.5   0.0      0.002   18.8   0.0    1.3  1  Abhydrolase_6  Alpha/beta hydrolase family
  ------ inclusion threshold ------
      0.021   14.7   0.0      0.044   13.6   0.0    1.5  1  Palm_thioest   Palmitoyl protein thioesterase
      0.071   12.4   0.0       0.15   11.3   0.0    1.5  1  Hydrolase_4    Serine aminopeptidase, S33


Domain annotation for each model (and alignments):
>> PGAP1  PGAP1-like protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !  163.8   0.0   1.7e-51   5.1e-48       3     231 .]     107     348 ..     105     348 .. 0.86

  Alignments for each domain:
  == domain 1  score: 163.8 bits;  conditional E-value: 1.7e-51
       PGAP1   3 sGipVlFvpGnagsykqvrslAseaaeayqe.....................lrkllknqnkkeldfftvdfneelsaldGrtlldqaeylndaIkyIl 80 
                  Gip+lFv+Gn gs+kq r+l+     ++ +                      ++ +k + ++++d f vdfne+lsal G  l +qa+y+  ++kyI+
  EFC39940.1 107 RGIPILFVHGNSGSMKQGRALGVSP-LEFISrlekyqlqdrvyldmfqgsflRENVEKAKLPQDFDVFLVDFNEQLSALSGDVLVRQAKYVRGVMKYIT 204
                 69*******************9888.44444577777777777777777775555588899999*********************************** PP

       PGAP1  81 slysssekeptsviliGHSmGGivaraaltlknyikqsvntiltlasPhalpplsfdkdilklyervnefwkkeleekeklenvllvsitggirdsmvp 179
                 sly+s+e++p+++i +GHSmGGiv +aa  l       ++t++tl++P +  p+ +d+d   +y+++ + ++          +v + si+gg +d +++
  EFC39940.1 205 SLYTSEENKPKEIIAVGHSMGGIVLKAASALTVKDILPIRTLITLSTPFKRHPVLLDRDSDLFYQQLVRLPH---------PKVDIFSIGGGWHDELIR 294
                 ************************88777777666788******************************9954.........35999************* PP

       PGAP1 180 aeyssleelvpstngl..svattsipkvwlsidhlaivwckqlrrvvarallev 231
                 ++++    l ++ +++   + tts+p++  s+dh+ai+wckq    +a++l+++
  EFC39940.1 295 SDLTGNPLLGKNNSNFyhIMSTTSVPNTHCSTDHQAITWCKQIILPIAKFLVHY 348
                 ****95555544444321345789***************************985 PP

>> DUF915  Alpha/beta hydrolase of unknown function (DUF915)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    3.0   0.0     0.018        53       4      25 ..     101     122 ..      98     127 .. 0.85
   2 !   13.3   0.0   1.3e-05     0.039      84     145 ..     191     255 ..     184     270 .. 0.78

  Alignments for each domain:
  == domain 1  score: 3.0 bits;  conditional E-value: 0.018
      DUF915   4 lksekkkeiPtifihGyggtae 25 
                  ks+ ++ iP++f+hG +g+ +
  EFC39940.1 101 PKSKYYRGIPILFVHGNSGSMK 122
                 5788899***********9865 PP

  == domain 2  score: 13.3 bits;  conditional E-value: 1.3e-05
      DUF915  84 kqakwlkkvlseLkkkYni.....kkfnavGhSmGglaltsYleeyaddkslPqlkklvtiggpfng 145
                  qak++  v++++ + Y       k++ avGhSmGg+ l    + + +d  l ++++l+t+ +pf  
  EFC39940.1 191 RQAKYVRGVMKYITSLYTSeenkpKEIIAVGHSMGGIVLKAASALTVKD-IL-PIRTLITLSTPFKR 255
                 699***********99975222226799********9887655544444.47.79999999999975 PP

>> DUF676  Putative serine esterase (DUF676)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.7   0.0   6.6e-07     0.002      62     126 ..     198     253 ..     112     254 .. 0.81

  Alignments for each domain:
  == domain 1  score: 17.7 bits;  conditional E-value: 6.6e-07
      DUF676  62 rlaeevlevvkkkkdknkkiSfvghSlGgliaraaiaklkekemtlkeaikglepvtfitlasPh 126
                  +++++ +   ++++k k i  vghS+Gg++ +aa a+  +           l + t+itl++P+
  EFC39940.1 198 GVMKYITSLYTSEENKPKEIIAVGHSMGGIVLKAASALTVKD---------ILPIRTLITLSTPF 253
                 578899999999999999***************999954422.........234679*******8 PP

>> Abhydrolase_6  Alpha/beta hydrolase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.8   0.0   6.6e-07     0.002      27     121 ..     170     277 ..     111     322 .. 0.50

  Alignments for each domain:
  == domain 1  score: 18.8 bits;  conditional E-value: 6.6e-07
                    CEEEEE--TTSTS-GGCS--HHHCHHHHHHHCCTT.............TTSEEEEEETCHHHHHHHHHHCC.......EE.EEES-..----TTTS CS
  Abhydrolase_6  27 vhvlapDlpGhGrsdpppldledladlaalldelaa...........gggpvvlvGHSlGGalalaaapla.....lvvg.vlldppptalpagll 105
                    + v+ +D+  +   +    d+  l+++a +++++ +            ++++++vGHS+GG++  aa +l+     ++++ + l++p    p +l 
     EFC39940.1 170 FDVFLVDFNEQL--SALSGDV--LVRQAKYVRGVMKyitslytseenKPKEIIAVGHSMGGIVLKAASALTvkdilPIRTlITLSTPFKRHPVLLD 261
                    333333332222..1111222..23334444444447777777888899999**********7777666768888765667777775433333334 PP

                    ----TTHHHHHHTT-C CS
  Abhydrolase_6 106 aaalelllallallrl 121
                    ++   ++++l +l ++
     EFC39940.1 262 RDSDLFYQQLVRLPHP 277
                    4444444444443333 PP

>> Palm_thioest  Palmitoyl protein thioesterase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.0   1.5e-05     0.044      41     102 ..     167     252 ..     110     272 .. 0.62

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.5e-05
  Palm_thioest  41 edrkasffgnlndqvea.................vckk........lelangfhaiGfSQGglflRalie.rcddkknvrnlislggp 102
                    +  + f+ ++n+q++a                             ++++++++a+G+S Gg++l a    +++d  ++r+li+l++p
    EFC39940.1 167 PQDFDVFLVDFNEQLSAlsgdvlvrqakyvrgvmK--YitslytseENKPKEIIAVGHSMGGIVLKAASAlTVKDILPIRTLITLSTP 252
                   45556667777777777777766555555555330..2455555578899****************975515555566*******988 PP

>> Hydrolase_4  Serine aminopeptidase, S33
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.3   0.0   5.1e-05      0.15      57     115 ..     194     257 ..     188     312 .. 0.71

  Alignments for each domain:
  == domain 1  score: 11.3 bits;  conditional E-value: 5.1e-05
  Hydrolase_4  57 dyvdDlaafvekvkeehpel..plfllGhSmGGliallyl.lrypd..kvaglilsaPalkika 115
                  +yv+ + ++++ + + ++++  +++ +GhSmGG++  ++  l+ +d   ++ li  ++ +k ++
   EFC39940.1 194 KYVRGVMKYITSLYTSEENKpkEIIAVGHSMGGIVLKAASaLTVKDilPIRTLITLSTPFKRHP 257
                  56666666666666444444349**********9865555333333446777777777776654 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (931 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       986  (0.0549947); expected 358.6 (0.02)
Passed bias filter:                      389  (0.0216967); expected 358.6 (0.02)
Passed Vit filter:                        35  (0.00195214); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               6  [number of targets reported over threshold]
# CPU time: 0.78u 0.31s 00:00:01.09 Elapsed: 00:00:00.49
# Mc/sec: 5678.78
//
Query:       EFC39941.1  [L=322]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        0.7   10.1   8.1       0.58   10.4   1.5    2.9  2  RhoGEF    RhoGEF domain


Domain annotation for each model (and alignments):
>> RhoGEF  RhoGEF domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.4   1.5   3.2e-05      0.58     141     182 .]     111     152 ..      26     152 .. 0.82
   2 ?   -2.6   0.1      0.32   5.7e+03      47      94 ..     159     196 ..     155     214 .. 0.57

  Alignments for each domain:
  == domain 1  score: 10.4 bits;  conditional E-value: 3.2e-05
                 HHHHHHHHHHHHHHHTS-TTSHHHHHHHHHHHHHHHHHHHHH CS
      RhoGEF 141 qRlprYpLLLkellkntpeshpdyealkkaleaikevaseiN 182
                  R+prY LL +++l   ++++ + + ++ +l +++e+++ +N
  EFC39941.1 111 GRMPRYSLLYQDILSRESDEDIKDRIINPILAKLNEICTLLN 152
                 6***************9999888889999*****99999887 PP

  == domain 2  score: -2.6 bits;  conditional E-value: 0.32
                 HHHHHHHHHH..HHHHHHHH.HHHTTSS-S-SHHHHHHHHSTHHHHHHHH CS
      RhoGEF  47 eilelhrsfl..leeLeerlkeseeqkeaqsigdvflkfadkfkkYseYc 94 
                 +++++ ++++  +e+Le+ l           i dv l++ +   +Y +++
  EFC39941.1 159 SVMNMRDEKFfqIENLENEL----------VIVDVTLNIKKF--MYGKFL 196
                 55566644442555555544..........355555555422..255544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (322 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       897  (0.0500307); expected 358.6 (0.02)
Passed bias filter:                      417  (0.0232584); expected 358.6 (0.02)
Passed Vit filter:                        30  (0.00167327); expected 17.9 (0.001)
Passed Fwd filter:                         1  (5.57756e-05); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.59u 0.35s 00:00:00.94 Elapsed: 00:00:00.55
# Mc/sec: 1768.90
//
Query:       EFC39942.1  [L=176]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    8.1e-20   71.4   0.0    7.5e-09   35.9   0.0    2.1  2  AAA_33           AAA domain
    5.8e-08   32.5   0.9    0.00025   20.6   0.0    2.1  2  KTI12            Chromatin associated protein KTI12
    2.3e-06   27.0   0.0     0.0016   17.8   0.0    2.1  2  Zeta_toxin       Zeta toxin
    6.9e-06   25.5   0.0     0.0046   16.3   0.0    2.1  2  6PF2K            6-phosphofructo-2-kinase
    9.9e-06   26.1   0.3    0.00014   22.4   0.3    2.2  1  AAA_18           AAA domain
      0.001   19.2   0.7     0.0036   17.4   0.7    1.9  1  tRNA_lig_kinase  tRNA ligase kinase domain
     0.0012   19.1   0.1      0.002   18.4   0.1    1.7  1  AAA_22           AAA domain
     0.0061   16.4   0.2      0.014   15.3   0.2    1.8  1  Sushi_2          Beta-2-glycoprotein-1 fifth domain
  ------ inclusion threshold ------
       0.02   14.7   0.1      0.035   13.8   0.1    1.4  1  Viral_helicase1  Viral (Superfamily 1) RNA helicase
      0.023   14.8   0.4       0.41   10.7   0.1    2.1  2  SKI              Shikimate kinase
      0.044   14.2   0.1       0.14   12.6   0.0    1.8  2  AAA_17           AAA domain
      0.079   12.8   0.2        1.5    8.6   0.1    2.4  2  dNK              Deoxynucleoside kinase
      0.096   13.1   0.2       0.22   11.9   0.0    1.7  2  RNA_helicase     RNA helicase


Domain annotation for each model (and alignments):
>> AAA_33  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   35.9   0.0   5.5e-12   7.5e-09       1      33 [.      20      53 ..      20      61 .. 0.93
   2 !   33.8   0.0   2.4e-11   3.2e-08      61     143 .]      61     144 ..      56     144 .. 0.93

  Alignments for each domain:
  == domain 1  score: 35.9 bits;  conditional E-value: 5.5e-12
      AAA_33  1 lvllvGlpGsGKstlaerllkklg.avllssdtl 33
                l++++G pGsGKst++e+l kk + +v++++dtl
  EFC39942.1 20 LIICCGFPGSGKSTFSEQLEKKSTnFVRVNQDTL 53
                79******************************98 PP

  == domain 2  score: 33.8 bits;  conditional E-value: 2.4e-11
      AAA_33  61 elarkalsagrnvildatnlsrrerarflklarrlgvpv.rivvvetdeetlkeRlakRaangddrsevpeealdrqkarferp 143
                 ++ +k  +++++vild  n+ +++r+ ++  a++lgv++  +v++ t +e++k +++ R+++ + +++   e++d++ ++f++p
  EFC39942.1  61 KVMEKSFKHNKSVILDRCNIHPKDRKMWITEAKKLGVKHiDLVWFATTPEQCKLNVKSRKNHPTLQADKADEVVDEFAKGFKPP 144
                 667788899****************************95489*********************999***************998 PP

>> KTI12  Chromatin associated protein KTI12
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   20.6   0.0   1.8e-07   0.00025       3      26 ..      20      43 ..      19      54 .. 0.88
   2 !   10.7   0.2   0.00019      0.27      59     169 ..      58     170 ..      49     175 .. 0.72

  Alignments for each domain:
  == domain 1  score: 20.6 bits;  conditional E-value: 1.8e-07
                EEEEE--TTSSHHHHHHHHHHHHH CS
       KTI12  3 LvvltGlPssGKstrakeLakale 26
                L++ +G+P sGKst++++L+k+ +
  EFC39942.1 20 LIICCGFPGSGKSTFSEQLEKKST 43
                9******************99755 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.00019
                 HHHHHHHHHHTT.SEEEE-S---SHHHHHHHHHHHHHTT-EEE.EEEEE--HHHHHHHHHHTT-S......S-HHHHHHHHHH---TTSS-GGGS-SEE CS
       KTI12  59 slrsavkrdLskekvVIvDslnyikgfRYeLyciakaakttlc.vvyvvapldvlvkwneereekee....yekelldaLiqRyeePdsknrWDsPlft 152
                 + ++ ++++ +++k VI+D  n     R   + +ak+   +++ +v  +++++++    ++r+++        +e++d+ ++ +  P+   +++ P   
  EFC39942.1  58 ECKKVMEKSFKHNKSVILDRCNIHPKDRKMWITEAKKLGVKHIdLVWFATTPEQCKLNVKSRKNHPTlqadKADEVVDEFAKGFKPPQ---QYEGPYEH 153
                 567788999*************99999999999*****98876588888888888776677777767222234455555555555554...55666666 PP

                 EE.TTS---HHHHHHHH CS
       KTI12 153 vlsaeeklpldeilkal 169
                 +++ + + + ++i+k++
  EFC39942.1 154 LYQVNSEKESQDIVKTI 170
                 66666666666666665 PP

>> Zeta_toxin  Zeta toxin
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.8   0.0   1.1e-06    0.0016      17      54 ..      19      53 ..       4      57 .. 0.85
   2 !    7.3   0.0    0.0018       2.5      85     146 ..      60     122 ..      54     142 .. 0.89

  Alignments for each domain:
  == domain 1  score: 17.8 bits;  conditional E-value: 1.1e-06
  Zeta_toxin 17 klillgGqpGAGKselaellkdelerqgnvvrldpDdl 54
                 li+  G pG+GKs+ +e l+++     n+vr+++D+l
  EFC39942.1 19 YLIICCGFPGSGKSTFSEQLEKKS---TNFVRVNQDTL 53
                467889*****************6...8********86 PP

  == domain 2  score: 7.3 bits;  conditional E-value: 0.0018
  Zeta_toxin  85 ekllqeaiengyniivegtlrspdvvkklaealkkaGYe.vevvvvavkkelSrlgvldRyee 146
                 +k++++ +++  ++i+++   +p + k  ++++kk G + + +v  a+ +e+  l v++R   
  EFC39942.1  60 KKVMEKSFKHNKSVILDRCNIHPKDRKMWITEAKKLGVKhIDLVWFATTPEQCKLNVKSRKNH 122
                 689999*****************************9*86489******************865 PP

>> 6PF2K  6-phosphofructo-2-kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !    7.2   0.0     0.002       2.7       5      35 ..      10      40 ..       6      54 .. 0.82
   2 !   16.3   0.0   3.3e-06    0.0046     101     186 ..      74     163 ..      56     175 .. 0.83

  Alignments for each domain:
  == domain 1  score: 7.2 bits;  conditional E-value: 0.002
                HHHHT..S-EEEEEESSTTSSHHHHHHHHHH CS
       6PF2K  5 tvtnlknsklvivlvGLpargKtyiskkltr 35
                ++ + + +  +i+  G p  gK++ s++l +
  EFC39942.1 10 STAKVTPETYLIICCGFPGSGKSTFSEQLEK 40
                55666778899****************9965 PP

  == domain 2  score: 16.3 bits;  conditional E-value: 3.3e-06
                 EEES---SHHHHHHHHHHHHHTT-EEEEEEEE--HHHHHHHHHHHHTTTSGGGTTS-HHHHHHHHHHHHH...HHHTT-----..TTTTTT CS
       6PF2K 101 ifDAtNttrerRklilefveennlkvlflesicsdeeiikeNikevklsspDYkdketeeaikdflkRle...nyekqyepld..deedee 186
                 i D  N+  ++Rk+ ++++++ ++k + l  +++ +e  k N+k  k + p  +  + +e++++f+k  +   +ye  ye l   ++e e+
  EFC39942.1  74 ILDRCNIHPKDRKMWITEAKKLGVKHIDLVWFATTPEQCKLNVKSRKNH-PTLQADKADEVVDEFAKGFKppqQYEGPYEHLYqvNSEKES 163
                 8899*******************************************99.****************9985444899999999733333333 PP

>> AAA_18  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.4   0.3     1e-07   0.00014       1      38 [.      21      52 ..      21     135 .. 0.73

  Alignments for each domain:
  == domain 1  score: 22.4 bits;  conditional E-value: 1e-07
      AAA_18  1 IlltGtpGvGKttlakeLskrl.gf....gvnlrdvakengll 38
                I+ +G pG+GK+t+++ L+k+  +f                  
  EFC39942.1 21 IICCGFPGSGKSTFSEQLEKKStNFvrvnQ-----------DT 52
                7889**************999655543331...........22 PP

>> tRNA_lig_kinase  tRNA ligase kinase domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   17.4   0.7   2.6e-06    0.0036       4      85 ..      23     100 ..      20     158 .. 0.83

  Alignments for each domain:
  == domain 1  score: 17.4 bits;  conditional E-value: 2.6e-06
                      EE--TTSSHHHHHHHHHHH-TTSEEEEGGGS-TT.-SS-HHHHHHHTTSSTT--EEEEES---SHHHHHHHHHHHHHHHHHH- CS
  tRNA_lig_kinase   4 piatiGCGkttvaltlenlfgeWghvqnDnitgk.dkkklvkealellkkdeskvvlvDrnnhqkreRkqlfeeidelkeeyl 85 
                           G Gk+t ++ le+   ++  v +D + +  + kk+++++   +  +++k v++Dr n + ++Rk  ++e ++l  +++
       EFC39942.1  23 CCGFPGSGKSTFSEQLEKKSTNFVRVNQDTLGDAsECKKVMEKS---F--KHNKSVILDRCNIHPKDRKMWITEAKKLGVKHI 100
                      5555699************************8764556666655...4..5568899************99999888877766 PP

>> AAA_22  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   18.4   0.1   1.5e-06     0.002       6      30 ..      19      43 ..      15     175 .. 0.78

  Alignments for each domain:
  == domain 1  score: 18.4 bits;  conditional E-value: 1.5e-06
      AAA_22  6 gilvvtGesGtGKTtllrrlleqld 30
                ++++++G +G+GK+t  ++l ++ +
  EFC39942.1 19 YLIICCGFPGSGKSTFSEQLEKKST 43
                789****************999864 PP

>> Sushi_2  Beta-2-glycoprotein-1 fifth domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.3   0.2     1e-05     0.014       6      55 ..      73     120 ..      68     168 .. 0.86

  Alignments for each domain:
  == domain 1  score: 15.3 bits;  conditional E-value: 1e-05
     Sushi_2   6 ipvkrarvlykgekvkiedllknrvlHgekvsffCknkekkCsytveaqC 55 
                 + ++r  +  k++k++i++ +k +v+H + v+f    + ++C  +v+++ 
  EFC39942.1  73 VILDRCNIHPKDRKMWITEAKKLGVKHIDLVWFA--TTPEQCKLNVKSRK 120
                 6678999999********************9984..45566777776665 PP

>> Viral_helicase1  Viral (Superfamily 1) RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.8   0.1   2.5e-05     0.035       4      40 ..      24      66 ..      21      96 .. 0.77

  Alignments for each domain:
  == domain 1  score: 13.8 bits;  conditional E-value: 2.5e-05
  Viral_helicase1  4 hGvpGcGKStlirkllrts.liltvnrptaelltegk.....p 40
                      G+pG+GKSt   +l ++s   ++vn+ t  +++e k     +
       EFC39942.1 24 CGFPGSGKSTFSEQLEKKStNFVRVNQDTLGDASECKkvmekS 66
                     69********999999998999999999999999988664333 PP

>> SKI  Shikimate kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    2.7   0.1     0.092   1.3e+02       1      15 [.      27      41 ..      27      72 .. 0.76
   2 ?   10.7   0.1    0.0003      0.41      83     153 ..      91     170 ..      54     174 .. 0.67

  Alignments for each domain:
  == domain 1  score: 2.7 bits;  conditional E-value: 0.092
                TTSSHHHHHHHHHHH CS
         SKI  1 mGaGKstvGkllAkk 15
                +G+GKst+ ++l kk
  EFC39942.1 27 PGSGKSTFSEQLEKK 41
                69******9998655 PP

  == domain 2  score: 10.7 bits;  conditional E-value: 0.0003
                 H......HHSEEEEEE--HHHHHHHHHHTTSSGGGCSCHHHHHHHHHHH.HHHH.HHCC.SSCEEEECTSSHHHHHHHHH CS
         SKI  83 k......ekgiviyLdvsleellerlkadkeRPllqekskeeelleela.erep.lyee.aadvvvdeseeskeevaeei 153
                 +      ++  +++  +++e+    +k++k+ P+lq+++ +e ++e+ +  + p  ye  +++    +se++++ ++++i
  EFC39942.1  91 EakklgvKHIDLVWFATTPEQCKLNVKSRKNHPTLQADKADEVVDEFAKgFKPPqQYEGpYEHLYQVNSEKESQDIVKTI 170
                 344444477779****************************9998888876554413444344433333333335555555 PP

>> AAA_17  AAA domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   12.6   0.0   9.8e-05      0.14       2      21 ..      25      45 ..      24      66 .. 0.86
   2 ?   -0.9   0.0       1.5     2e+03      70      86 ..      69      85 ..      46     135 .. 0.54

  Alignments for each domain:
  == domain 1  score: 12.6 bits;  conditional E-value: 9.8e-05
                E-TTSSHHHHHHHHHHHH.TE CS
      AAA_17  2 GgPGsGKgtqceklveky.gf 21
                G PGsGK+t +e+l +k  +f
  EFC39942.1 25 GFPGSGKSTFSEQLEKKStNF 45
                99************9875355 PP

  == domain 2  score: -0.9 bits;  conditional E-value: 1.5
                HSSEEEEEE-SEEEETT CS
      AAA_17 70 kkkgvlvdghprikeqa 86
                 +k v++d      +++
  EFC39942.1 69 HNKSVILDRCNIHPKDR 85
                34445555443333333 PP

>> dNK  Deoxynucleoside kinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.6   0.1    0.0011       1.5       5      46 ..      25      67 ..      21      76 .. 0.62
   2 ?    2.2   0.0     0.099   1.4e+02     126     146 ..     102     122 ..      56     130 .. 0.69

  Alignments for each domain:
  == domain 1  score: 8.6 bits;  conditional E-value: 0.0011
                ESTTSSHHHHHHHHHCCST..CEEEE-HHHHCCSSSS..HHHHHHH CS
         dNK  5 GnIgaGKstlvklLskklg..vkvfeEpvdkwtnvqk..nlLekfY 46
                G  g+GKst+ ++L+kk    v v ++   +     +  +++ek +
  EFC39942.1 25 GFPGSGKSTFSEQLEKKSTnfVRVNQDTLGDA---SEckKVMEKSF 67
                5569***********99843333333333333...22335665555 PP

  == domain 2  score: 2.2 bits;  conditional E-value: 0.099
                 EEEEE--HHHHHHHHHHCTTC CS
         dNK 126 liYLkasletclerikkRgre 146
                 l++  +++e+c+ ++k R+++
  EFC39942.1 102 LVWFATTPEQCKLNVKSRKNH 122
                 688899999999999998875 PP

>> RNA_helicase  RNA helicase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.9   0.0   0.00016      0.22       1      56 [.      21      76 ..      21      99 .. 0.67
   2 ?   -2.0   0.0       3.4   4.6e+03      50      64 ..     146     160 ..     114     174 .. 0.58

  Alignments for each domain:
  == domain 1  score: 11.9 bits;  conditional E-value: 0.00016
  RNA_helicase  1 iwlyGpsgeGKStlakeLakallkklklkkkdsvysrnpeddfwdgYtgqevvvid 56
                  i+ +G +g GKSt++++L k+ ++ +  +++    + ++++ + +++++++ v+ d
    EFC39942.1 21 IICCGFPGSGKSTFSEQLEKKSTNFVRVNQDTLGDASECKKVMEKSFKHNKSVILD 76
                  6789*************999888777555533333344444444556665555555 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 3.4
  RNA_helicase  50 qevvvidDfgqvkde 64 
                   q    ++ ++qv++e
    EFC39942.1 146 QYEGPYEHLYQVNSE 160
                   333334444555544 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (176 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       745  (0.0415528); expected 358.6 (0.02)
Passed bias filter:                      454  (0.0253221); expected 358.6 (0.02)
Passed Vit filter:                        77  (0.00429472); expected 17.9 (0.001)
Passed Fwd filter:                        13  (0.000725082); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):              13  [number of targets reported over threshold]
# CPU time: 0.57u 0.35s 00:00:00.92 Elapsed: 00:00:00.52
# Mc/sec: 1014.36
//
Query:       EFC39943.1  [L=523]
Description: hypothetical protein NAEGRDRAFT_81174 [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
    4.8e-10   39.9   0.3     0.0078   16.8   0.0    4.5  3  RCC1      Regulator of chromosome condensation (RCC1) repeat
    1.9e-09   37.1   1.5     0.0001   22.0   0.1    2.8  2  RCC1_2    Regulator of chromosome condensation (RCC1) repeat


Domain annotation for each model (and alignments):
>> RCC1  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.8   0.0   8.7e-07    0.0078       4      48 ..      83     139 ..      81     141 .. 0.88
   2 !   14.9   0.3   3.6e-06     0.032       3      49 ..     146     223 ..     144     224 .. 0.67
   3 ?    1.9   0.0     0.039   3.5e+02      35      49 ..     272     287 ..     259     288 .. 0.77

  Alignments for each domain:
  == domain 1  score: 16.8 bits;  conditional E-value: 8.7e-07
                 EEEEE--GGGTTSSSS-........--EEEEEE-GGGTTS.......-EEEEEEETTEEE CS
        RCC1   4 VysWGrndyGqLGlgtt........esvlvPtkveglsgn.......rvvkvacGddhtv 48 
                 +++ G+nd  qLG   +        ++v   t+++gls+n       rv  +acG +h++
  EFC39943.1  83 IFTSGSNDSAQLGFDRNdvssmeewKEV---TQIKGLSDNeseeilsRVNIIACGRSHSL 139
                 89************77766666666677...****************************8 PP

  == domain 2  score: 14.9 bits;  conditional E-value: 3.6e-06
                 EEEEEE--GGGTTSSSS---E.........EE.......EEE-.......GGGTTS...........-EEE.EEEETTEEEE CS
        RCC1   3 rVysWGrndyGqLGlgttesv.........lv.......Ptkv.......eglsgn...........rvvk.vacGddhtva 49 
                 +V+++G+n+y+qL + ++e v         l+       P+ +       +    +             v+ vacG++ht+ 
  EFC39943.1 146 KVFGCGKNNYNQLQTEPSEYVelfsplndyLTsamsnalPSIIrtrnwseK----QesfirqhfsniQTVDfVACGWFHTII 223
                 7**************999555444545544114555556988877755550....34445556887755556********86 PP

  == domain 3  score: 1.9 bits;  conditional E-value: 0.039
                 S.-EEEEEEETTEEEE CS
        RCC1  35 n.rvvkvacGddhtva 49 
                 + rv++ +cG + +++
  EFC39943.1 272 TyRVTDLTCGTFSSAL 287
                 269********99986 PP

>> RCC1_2  Regulator of chromosome condensation (RCC1) repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   22.0   0.1   1.1e-08    0.0001       4      30 .]     131     157 ..     125     157 .. 0.97
   2 !   13.2   0.1   6.5e-06     0.058       4      27 ..     214     237 ..     210     240 .. 0.89

  Alignments for each domain:
  == domain 1  score: 22.0 bits;  conditional E-value: 1.1e-08
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNsdGQ 30 
                 +++G++Hs++ t+d +V+++G N++ Q
  EFC39943.1 131 IACGRSHSLIATSDAKVFGCGKNNYNQ 157
                 8***********************998 PP

  == domain 2  score: 13.2 bits;  conditional E-value: 6.5e-06
      RCC1_2   4 vsaGdyHscaLtedGeVlcWGsNs 27 
                 v++G++H++++++ +++l+ G+  
  EFC39943.1 214 VACGWFHTIIVVNRNIILGAGHSY 237
                 9*****************999865 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (523 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1000  (0.0557756); expected 358.6 (0.02)
Passed bias filter:                      561  (0.0312901); expected 358.6 (0.02)
Passed Vit filter:                        45  (0.0025099); expected 17.9 (0.001)
Passed Fwd filter:                         2  (0.000111551); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               2  [number of targets reported over threshold]
# CPU time: 0.73u 0.31s 00:00:01.04 Elapsed: 00:00:00.51
# Mc/sec: 3074.91
//
Query:       EFC39944.1  [L=418]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    1.8e-37  129.2  16.3      1e-20   74.4   9.0    2.1  2  TauE             Sulfite exporter TauE/SafE
  ------ inclusion threshold ------
      0.056   13.5   0.1      0.056   13.5   0.1    3.4  4  Gly-zipper_Omp   Glycine zipper
       0.21   11.8   0.0       0.45   10.7   0.0    1.5  1  PRCH             Photosynthetic reaction centre, H-chain N-te
       0.24   11.2   3.3        2.2    8.1   1.7    2.6  2  PAP2             PAP2 superfamily


Domain annotation for each model (and alignments):
>> TauE  Sulfite exporter TauE/SafE
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   59.5   0.7   7.9e-20   3.6e-16     119     233 ..     137     255 ..      96     257 .. 0.89
   2 !   74.4   9.0   2.3e-24     1e-20       1     110 [.     296     416 ..     296     418 .] 0.96

  Alignments for each domain:
  == domain 1  score: 59.5 bits;  conditional E-value: 7.9e-20
        TauE 119 rerrptaillvligglvGllsGllGiGgGfllvpllllll..glplkkavatslllilvislagalgyal..agavdwpllllllpgallGallGarla 213
                 + ++ + + l+ + +++G ++G++G Gg ++l+pl + l+   l+ k++vat l+ +++ +++ga ++++    +vd+ + +l++  a+++a +G++l+
  EFC39944.1 137 VFNTWDFVKLFGVSIVGGTFGGMVGLGGNIILIPLITQLFphLLSAKQIVATCLVTVVTAGFVGAGTLYFvgDNSVDIVTSILIATFAAFTARFGVKLS 235
                 4556677778888888*************************99*********************99986656888999999999999************ PP

        TauE 214 rrlsertlrrlfallllvlg 233
                 + + +rtl++++a+++l+++
  EFC39944.1 236 SSIQDRTLKLILACFMLFVA 255
                 *****************987 PP

  == domain 2  score: 74.4 bits;  conditional E-value: 2.3e-24
        TauE   1 lllagllaGfvagllGiGggliavPlLllll...........ppavavatsllavvatslsgalahrrrgnvdwrlllllllgsliGallGallllllp 88 
                 l+++g ++G+++gllG+Ggg+++vP+L +l            + +++++tsl+a+++ s +++++h+r gnv ++l+ +l+ gs++Ga+ G++l++ ++
  EFC39944.1 296 LFVLGSIIGVMSGLLGVGGGILIVPALSFLWsdkspikkehtSTKLVIGTSLAAMTIPSSVALYSHWRVGNVILKLAPILMTGSAVGAYSGGFLASNMD 394
                 5899*************************75789999****99999***************************************************** PP

        TauE  89 sellkllfgvlllllallmllr 110
                 +++lk  f++ +lll+++ +++
  EFC39944.1 395 EQVLKHTFSLTMLLLGIRQFWK 416
                 ******************9987 PP

>> Gly-zipper_Omp  Glycine zipper
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.8   4.1      0.35   1.6e+03      29      39 ..     151     161 ..     148     166 .. 0.77
   2 ?   -4.1   0.3       3.8   1.7e+04      26      28 ..     199     201 ..     194     208 .. 0.58
   3 ?   -4.0   3.9       3.6   1.6e+04       9      23 ..     299     315 ..     293     318 .. 0.57
   4 ?   13.5   0.1   1.2e-05     0.056      27      45 ..     378     396 ..     374     397 .. 0.93

  Alignments for each domain:
  == domain 1  score: -0.8 bits;  conditional E-value: 0.35
  Gly-zipper_Omp  29 avGaavGgliG 39 
                     +vG++ Gg++G
      EFC39944.1 151 IVGGTFGGMVG 161
                     67888888777 PP

  == domain 2  score: -4.1 bits;  conditional E-value: 3.8
  Gly-zipper_Omp  26 iGA 28 
                     +GA
      EFC39944.1 199 VGA 201
                     333 PP

  == domain 3  score: -4.0 bits;  conditional E-value: 3.6
  Gly-zipper_Omp   9 aGaliGgavg..grgtG 23 
                     +G++iG  +g  g g G
      EFC39944.1 299 LGSIIGVMSGllGVGGG 315
                     56666666654444444 PP

  == domain 4  score: 13.5 bits;  conditional E-value: 1.2e-05
  Gly-zipper_Omp  27 GAavGaavGgliGaamdkq 45 
                     G avGa++Gg  + +md+q
      EFC39944.1 378 GSAVGAYSGGFLASNMDEQ 396
                     99***************98 PP

>> PRCH  Photosynthetic reaction centre, H-chain N-terminal region
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   10.7   0.0    0.0001      0.45      11      57 ..     244     289 ..     240     295 .. 0.87

  Alignments for each domain:
  == domain 1  score: 10.7 bits;  conditional E-value: 0.0001
                 HHHHHHHHHHHHHHHHHHHHHTTSSS-S-B-TTSSB-S---SS---- CS
        PRCH  11 qlvlyaFwiFfagLifYlrrEdkREGYPleseetekekvqgvlavpe 57 
                 +l+l  F++F a L+  l+ +d++E  P++++++e++++++ l++p+
  EFC39944.1 244 KLILACFMLFVAPLVSLLHSDDEKE-KPVSDSTKEQSETNQKLKLPS 289
                 58999********************.599999999987777777775 PP

>> PAP2  PAP2 superfamily
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    8.1   1.7   0.00049       2.2      70     126 ..     171     227 ..     165     236 .. 0.85
   2 ?    1.5   0.0     0.052   2.3e+02      70     110 ..     321     363 ..     313     367 .. 0.73

  Alignments for each domain:
  == domain 1  score: 8.1 bits;  conditional E-value: 0.00049
        PAP2  70 llalllrrkrkkiglvllalillllavlvalsRlylgvHflsDvlaGlliGialaal 126
                 l++ l++ + + ++ v+++l++++ a +v+++ ly+      D+++++li+++ a+ 
  EFC39944.1 171 LITQLFPHLLSAKQIVATCLVTVVTAGFVGAGTLYFVGDNSVDIVTSILIATFAAFT 227
                 55666666666667899***********************************99875 PP

  == domain 2  score: 1.5 bits;  conditional E-value: 0.052
        PAP2  70 llalllrrkrkkig..lvllalillllavlvalsRlylgvHfl 110
                 +l++l+ +k + ++  ++  ++i + la++++ s ++l+ H++
  EFC39944.1 321 ALSFLWSDKSPIKKehTSTKLVIGTSLAAMTIPSSVALYSHWR 363
                 4444454444444477666778889999**************7 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (418 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1097  (0.0611858); expected 358.6 (0.02)
Passed bias filter:                      612  (0.0341346); expected 358.6 (0.02)
Passed Vit filter:                        50  (0.00278878); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.67u 0.35s 00:00:01.02 Elapsed: 00:00:00.54
# Mc/sec: 2339.60
//
Query:       EFC39945.1  [L=119]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model          Description
    ------- ------ -----    ------- ------ -----   ---- --  --------       -----------
     0.0072   16.3   4.3     0.0085   16.1   4.3    1.1  1  Alpha-2-MRAP_C  Alpha-2-macroglobulin RAP, C-terminal domain
  ------ inclusion threshold ------
      0.028   14.4   1.1      0.052   13.6   0.3    1.9  2  U62_UL91        Functional domain of U62 and UL91 proteins
       0.26   11.2   9.1       0.29   11.0   5.2    2.0  2  DrrA_P4M        DrrA phosphatidylinositol 4-phosphate binding
       0.44   10.5   5.5        1.5    8.7   1.6    2.0  2  Lipoprotein_20  YfhG lipoprotein


Domain annotation for each model (and alignments):
>> Alpha-2-MRAP_C  Alpha-2-macroglobulin RAP, C-terminal domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   16.1   4.3   1.9e-06    0.0085      20      94 ..      15      96 ..       7     111 .. 0.76

  Alignments for each domain:
  == domain 1  score: 16.1 bits;  conditional E-value: 1.9e-06
  Alpha-2-MRAP_C 20 teeeLekLkeEfkhhqeKideYnsLleelekeeekheNaiseeeldkvneieeeee........kkkeylekenelkekhrel 94
                    +++ L+ Lk Ef   ++K+d + +++++++++++ ++N+i + + d++ + ++++e        +kk++    nelk++ + +
      EFC39945.1 15 SSSSLNDLKMEFYSLETKLD-FTKIIQKINNSTKVQQNVITKYKNDSYFRVNKNSEkfmdemeaQKKTQIVYLNELKQRVKMI 96
                    6788**************97.999****************9999999888888877455555444444444455555555544 PP

>> U62_UL91  Functional domain of U62 and UL91 proteins
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   13.6   0.3   1.2e-05     0.052       3      30 ..      17      44 ..      15      55 .. 0.90
   2 ?   -2.0   0.0      0.83   3.7e+03       6      13 ..      87      94 ..      85     117 .. 0.46

  Alignments for each domain:
  == domain 1  score: 13.6 bits;  conditional E-value: 1.2e-05
    U62_UL91  3 slLaelkddfeacetkeDlFkiiDklsk 30
                s L++lk +f + etk D  kii k+ +
  EFC39945.1 17 SSLNDLKMEFYSLETKLDFTKIIQKINN 44
                89***********************975 PP

  == domain 2  score: -2.0 bits;  conditional E-value: 0.83
    U62_UL91  6 aelkddfe 13
                +elk+  +
  EFC39945.1 87 NELKQRVK 94
                55554332 PP

>> DrrA_P4M  DrrA phosphatidylinositol 4-phosphate binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   11.0   5.2   6.5e-05      0.29      35      99 ..      19      83 ..      16      86 .. 0.89
   2 ?    3.2   0.2     0.017        77      31      59 ..      80     110 ..      80     118 .. 0.79

  Alignments for each domain:
  == domain 1  score: 11.0 bits;  conditional E-value: 6.5e-05
                HHHHHHHHTT--SHHHHHHHHHHHHTSHHHHHHHS-SSHHHHHHT---HHHHHHHHHHHHHHHTT CS
    DrrA_P4M 35 LkdfKdkleeistkeeLeklvkefkkseeykilktgQglftrlfglkTssvkalekivkeaekei 99
                L+d+K ++ +++tk +++k+++++++s +++     + +  + f+++ +s k ++++ ++++++i
  EFC39945.1 19 LNDLKMEFYSLETKLDFTKIIQKINNSTKVQQNVITKYKNDSYFRVNKNSEKFMDEMEAQKKTQI 83
                99*************************9987665666666778*****************99998 PP

  == domain 2  score: 3.2 bits;  conditional E-value: 0.017
                 HHHH..HHHHHHHHTT--SHHHHHHHHHHHH CS
    DrrA_P4M  31 KtkI..LkdfKdkleeistkeeLeklvkefk 59 
                 Kt+I  L+++K++++ is+ e + +l+k ++
  EFC39945.1  80 KTQIvyLNELKQRVKMISDLEIFYNLRKILR 110
                 56665589************99999888665 PP

>> Lipoprotein_20  YfhG lipoprotein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    4.7   0.4    0.0057        26     123     163 ..      11      53 ..       4      61 .. 0.80
   2 ?    8.7   1.6   0.00033       1.5     117     166 ..      58     107 ..      46     113 .. 0.86

  Alignments for each domain:
  == domain 1  score: 4.7 bits;  conditional E-value: 0.0057
  Lipoprotein_20 123 lqeesdskldslreqqaaLeaeLeett..rKLenLtdiERqLs 163
                      q +s s l+ l+ +   Le++L+ t+  +K++n t +   + 
      EFC39945.1  11 SQVQSSSSLNDLKMEFYSLETKLDFTKiiQKINNSTKVQQNVI 53 
                     5788999***************987654499999999877655 PP

  == domain 2  score: 8.7 bits;  conditional E-value: 0.00033
  Lipoprotein_20 117 raryqrlqeesdskldslreqqaaLeaeLeettrKLenLtdiERqLssRk 166
                        y r++++s++ +d++ +q+++    L+e +++++ ++d+E     Rk
      EFC39945.1  58 NDSYFRVNKNSEKFMDEMEAQKKTQIVYLNELKQRVKMISDLEIFYNLRK 107
                     46799*************************************97776666 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (119 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      2449  (0.136594); expected 358.6 (0.02)
Passed bias filter:                      530  (0.029561); expected 358.6 (0.02)
Passed Vit filter:                        42  (0.00234257); expected 17.9 (0.001)
Passed Fwd filter:                         4  (0.000223102); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               4  [number of targets reported over threshold]
# CPU time: 0.57u 0.33s 00:00:00.89 Elapsed: 00:00:00.55
# Mc/sec: 656.98
//
Query:       EFC39946.1  [L=425]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model    Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
  ------ inclusion threshold ------
        2.2    8.0  23.1       0.16   11.7   3.1    2.7  3  DUF1282   Protein of unknown function (DUF1282)


Domain annotation for each model (and alignments):
>> DUF1282  Protein of unknown function (DUF1282)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.7   0.2      0.24   4.2e+03     110     125 ..      44      59 ..      25      75 .. 0.67
   2 ?   11.7   3.1     9e-06      0.16      63     131 ..     161     226 ..     101     231 .. 0.72
   3 ?    6.3   7.0    0.0004       7.2      66     147 ..     252     361 ..     249     372 .. 0.88

  Alignments for each domain:
  == domain 1  score: -2.7 bits;  conditional E-value: 0.24
     DUF1282 110 flgglalglsllllva 125
                 +l++++l++++ l v+
  EFC39946.1  44 SLLAFILLYIPTLIVY 59 
                 3455555555555444 PP

  == domain 2  score: 11.7 bits;  conditional E-value: 9e-06
     DUF1282  63 liisvvfylalgvlvlayliklmgrtydsqhsyskifafaayalvplflgglalglsllllvalvslll 131
                   is+  yl+  +l+l  ++k+ ++ ++ +++ +k++ ++ y  v+l+l  +a+++ l  lv++++l+l
  EFC39946.1 161 DYISIYWYLFNYTLILPIWLKVCMSWMGQTTK-KKAITITIY--VILILCNIAAFVGLAPLVVMAILAL 226
                 4689999*******************999999.566666655..5666777777766666666555555 PP

  == domain 3  score: 6.3 bits;  conditional E-value: 0.0004
     DUF1282  66 svvfylalgvlvlayliklmgrtydsqhs.......yskifafaayalvplflgglalglsllllva.....................lvslllllyvv 136
                 +v+++la+ ++ +a +i+++  t  sq++        +++++  ++a v+l +g ++ ++ + +  +                     +v+l++++y +
  EFC39946.1 252 AVLAVLAMSIACVAIIIHMIKATSKSQPEdgelyilQKQTIVKLTVAVVILGIGVIVRLVAVAIYAIdlpsyviyplvkaipdvsfalCVILIFWPYRL 350
                 7999*******************99999999998876788888888888888888888888888888999***************************99 PP

     DUF1282 137 vLlylGvptlm 147
                  +l + v+ +m
  EFC39946.1 351 PVLSHPVQFVM 361
                 99999888888 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (425 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1327  (0.0740142); expected 358.6 (0.02)
Passed bias filter:                      510  (0.0284455); expected 358.6 (0.02)
Passed Vit filter:                        37  (0.0020637); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               1  [number of targets reported over threshold]
# CPU time: 0.70u 0.30s 00:00:01.00 Elapsed: 00:00:00.51
# Mc/sec: 2500.88
//
Query:       EFC39947.1  [L=405]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model      Description
    ------- ------ -----    ------- ------ -----   ---- --  --------   -----------
    1.9e-24   86.8   1.4    1.9e-24   86.8   1.4    1.5  2  RNA_ligase  RNA ligase
    9.2e-24   83.4   0.7    9.2e-24   83.4   0.7    2.1  2  T4_Rnl2_C   T4 RNA ligase 2 C-terminal
     0.0078   15.1   0.2      0.011   14.6   0.2    1.4  1  Trehalase   Trehalase
  ------ inclusion threshold ------
       0.05   13.5   0.0       0.33   10.9   0.0    2.3  2  DUF3437     Domain of unknown function (DUF3437)
       0.18   11.6   4.0       0.22   11.3   2.6    1.9  2  DUF2286     Uncharacterized protein conserved in archaea (DUF


Domain annotation for each model (and alignments):
>> RNA_ligase  RNA ligase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   86.8   1.4   5.3e-28   1.9e-24       2     161 .]      35     276 ..      34     276 .. 0.75
   2 ?   -3.1   0.1       2.4   8.4e+03     100     110 ..     366     377 ..     335     403 .. 0.49

  Alignments for each domain:
  == domain 1  score: 86.8 bits;  conditional E-value: 5.3e-28
                 EEEEEEE-SSEEEEEEEETT..............EEEEETTCEB..........C.TTTHHHHHHTHHHHHHHHHHHHH..................EC CS
  RNA_ligase   2 evvvtEKlDGtnfriylvke..............vgvasRsqil..........p.fgeekfkefkrwaaalrkklkekla................ne 59 
                 ++vv+EK++G+nf++++ ++              ++vasR+q++          +   +e+ + f + ++  r++++e+++                ++
  EFC39947.1  35 PWVVSEKIHGCNFSFVMWRDnyqtansclvediqCQVASRRQYVgldeeekqkkKkSPHEDDDFFPEAVEIVRNRYEEQIKkvfksicdiysndnfkVR 133
                 7*****************77788999******************8876655443132333333344444444445555555555577788889999977 PP

                 CEEEEEEEES......SS.......TTSS.............EEEEEEEEEEE.....CTTBECE--HHHH.HHHHHCCT...B..EEEEE.SSHHHHH CS
  RNA_ligase  60 elilyGElig.....hsi.....kygglpk............efyvFdifdir.....dkeeqrylspdev.ealakglg...tvpvlyegkflaaeel 127
                 +  +yGE++g     ++i     +                  +fy+Fd++++      +kee+ yl +d++ + l +  g   +++ + +g   ++ee+
  EFC39947.1 134 RANFYGEIFGgqyphDQIenvkgR-----YpiqkhvyytpdyDFYMFDVYVFGlnvetKKEEGFYLAYDKMiQLLTE-CGisrYAKEVMRG---TLEEC 223
                 8*********66554333544443.....0444558888889********99888777777**********666666.5544544444444...67999 PP

                 CCC.................H.HHHTC--EEEEEESSSSBE.TTE.BSEEEEE CS
  RNA_ligase 128 lel................ll.skgnkrEGlVikpeselyk.nkg.raifKvk 161
                 le+                l+ s  n++EG+Vikp +++++ +kg r+i+K k
  EFC39947.1 224 LEYdcnyptkipqlfynlpLVeSCPNICEGVVIKPIRDMFTkEKGeRFIIKKK 276
                 9999999*******99974236999****************9999******76 PP

  == domain 2  score: -3.1 bits;  conditional E-value: 2.4
                 HHHH.HHHHHCC CS
  RNA_ligase 100 pdev.ealakgl 110
                  ++v ++   ++
  EFC39947.1 366 LAKVdQKAISKY 377
                 333322222222 PP

>> T4_Rnl2_C  T4 RNA ligase 2 C-terminal
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   83.4   0.7   2.6e-27   9.2e-24       4      81 ..     304     383 ..     301     384 .. 0.94
   2 ?   -3.7   0.2       3.9   1.4e+04      51      63 ..     387     399 ..     385     404 .. 0.37

  Alignments for each domain:
  == domain 1  score: 83.4 bits;  conditional E-value: 2.6e-27
                 -TTTHHHHHHHGGG--HHHHHHHHHTSS--S..TTTHHHHHHHHHHHHHHHHHHT...T--SSSSSSHHHHHHHHHHHHH CS
   T4_Rnl2_C   4 seeleelleeierYvtenRLnNviSKigeit..rknfgkvlkafvqDaledfnkeeeaelsslskeeqkvikkklnkeiq 81 
                 +++++ +++ i +Y+++nRL+++iSKig+i    k ++k+l++fvqD+l df+ke+++e++sl+k +qk+i+k+l++e++
  EFC39947.1 304 ESVSTPVFDLIVQYLNDNRLESAISKIGNIItsFKLRNKCLALFVQDILADFKKEHSNEWDSLAKVDQKAISKYLSDEAK 383
                 56778999********************99889********************************************987 PP

  == domain 2  score: -3.7 bits;  conditional E-value: 3.9
                 HHHHHT...T--S CS
   T4_Rnl2_C  51 edfnkeeeaelss 63 
                 +d+  e+ +e ++
  EFC39947.1 387 TDYVYEYTTEEQK 399
                 5555555222222 PP

>> Trehalase  Trehalase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.6   0.2   3.1e-06     0.011     321     372 ..     345     399 ..     264     405 .] 0.84

  Alignments for each domain:
  == domain 1  score: 14.6 bits;  conditional E-value: 3.1e-06
                 H.HCCCHCC-..CCHHHHHHHHHHHHHHHHHHHCEETTTTEE--EETTTTEE--- CS
   Trehalase 321 a.efedklgd..setseefeekaekrkkaidkvLWneeagvylDYdlkkkkqtny 372
                 a +++d l d  +e+s+e+++ a+  +kai k+L +e++++  DY  + ++++++
  EFC39947.1 345 AlFVQDILADfkKEHSNEWDSLAKVDQKAISKYLSDEAKEIITDYVYEYTTEEQK 399
                 334555555577999*****************************98776544333 PP

>> DUF3437  Domain of unknown function (DUF3437)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -1.1   0.0      0.52   1.9e+03      23      49 ..     231     257 ..     225     282 .. 0.52
   2 ?   10.9   0.0   9.1e-05      0.33      46      64 ..     347     365 ..     323     390 .. 0.80

  Alignments for each domain:
  == domain 1  score: -1.1 bits;  conditional E-value: 0.52
     DUF3437  23 PkwlpevleeLaraardpapirktvkk 49 
                 P+ +p+++ +L   ++ p+ ++  v k
  EFC39947.1 231 PTKIPQLFYNLPLVESCPNICEGVVIK 257
                 556666666655555555544443332 PP

  == domain 2  score: 10.9 bits;  conditional E-value: 9.1e-05
     DUF3437  46 tvkktlseFkrthqDtWee 64 
                  v+++l++Fk+ h+++W+ 
  EFC39947.1 347 FVQDILADFKKEHSNEWDS 365
                 5899*************54 PP

>> DUF2286  Uncharacterized protein conserved in archaea (DUF2286)
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -2.8   0.0       1.4   4.9e+03     107     125 ..     313     331 ..     301     341 .. 0.64
   2 ?   11.3   2.6   6.1e-05      0.22      90     137 ..     359     403 ..     351     404 .. 0.86

  Alignments for each domain:
  == domain 1  score: -2.8 bits;  conditional E-value: 1.4
     DUF2286 107 vvapyiddeakkeleeeaa 125
                 ++  y++d+  +  + ++ 
  EFC39947.1 313 LIVQYLNDNRLESAISKIG 331
                 6778888887666555555 PP

  == domain 2  score: 11.3 bits;  conditional E-value: 6.1e-05
     DUF2286  90 fdnewidedtyvdkkvyvvapyiddeakkeleeeaaevtkeekeeeae 137
                 ++new     +vd+k   ++ y++deak+ +++++ e t+ee+++++e
  EFC39947.1 359 HSNEWD-SLAKVDQKA--ISKYLSDEAKEIITDYVYEYTTEEQKQQEE 403
                 577777.677888888..9**********************9987765 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (405 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                      1336  (0.0745161); expected 358.6 (0.02)
Passed bias filter:                      567  (0.0316247); expected 358.6 (0.02)
Passed Vit filter:                        41  (0.0022868); expected 17.9 (0.001)
Passed Fwd filter:                         5  (0.000278878); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               5  [number of targets reported over threshold]
# CPU time: 0.63u 0.33s 00:00:00.96 Elapsed: 00:00:00.52
# Mc/sec: 2321.90
//
Query:       EFC39948.1  [L=315]
Description: predicted protein [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model           Description
    ------- ------ -----    ------- ------ -----   ---- --  --------        -----------
    3.6e-08   33.3   0.0    4.6e-08   32.9   0.0    1.1  1  NmrA             NmrA-like family
      8e-05   22.9   0.0    0.00017   21.9   0.0    1.6  1  Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding doma
    0.00065   19.6   0.0    0.00096   19.1   0.0    1.3  1  NAD_binding_10   NAD(P)H-binding
     0.0011   19.1   0.0      0.011   15.9   0.0    2.2  2  DapB_N           Dihydrodipicolinate reductase, N-terminus
     0.0053   15.8   0.1       0.01   14.9   0.1    1.4  1  3Beta_HSD        3-beta hydroxysteroid dehydrogenase/isomeras
  ------ inclusion threshold ------
       0.17   11.0   0.0       0.43    9.7   0.0    1.6  2  NAD_binding_4    Male sterility protein
       0.39   10.7   2.5        1.1    9.2   0.7    2.4  2  Pox_A_type_inc   Viral A-type inclusion protein repeat


Domain annotation for each model (and alignments):
>> NmrA  NmrA-like family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   32.9   0.0   1.8e-11   4.6e-08       1     226 [.      10     239 ..      10     245 .. 0.81

  Alignments for each domain:
  == domain 1  score: 32.9 bits;  conditional E-value: 1.8e-11
                 EEESSTTSHHHHHHHHHHHH...HT-EEEEEES-S-SHHHHHHHHSTTEEE.ES-.T.T-HHHHHHHHTT-SEEEE---GG..S-HHHHHHHHHHHHHH CS
        NmrA   1 IlviGaTGrqGksvvrallk...aghkvralvRdtkselakslkeaGvelv.kgd.l.ddkeslvealkgvdvvfsvtgfy..skeiedgkklvdAake 91 
                 +l++Ga+G++G ++v+ l +   ++ k   lv  +++++++  +++ +  + + d l d+ e  v++lk+  +v   ++f+  ++e++  +++++   +
  EFC39948.1  10 VLILGASGHLGCQIVKNLCEnhqKDVKCSLLVPSESRDKLNVWEKKLNGKIfCFDvLkDSCEDFVNILKDFTLVLNCMNFFdhEEELKAETRVIESCIK 108
                 79****************998888899999**9998877777666555444455534255699****************999999************** PP

                 HS-SEEEEEE---GG.GT.SSS---TTTHHHHHHHHHHHHC.TS-EEEEEE-EEGGG-BSSS-SS-BEEE-TTS.-EEEEESS-TTS-EE-HHHHHHHH CS
        NmrA  92 aGvkhfiySslgddndrsnaeepavphfdsKaeieeyvral.gipytfvyagffmenflsllaqlkvgdtappedkvtllgpgnpkavlldaeeDiGaf 189
                 a vk +i+S +  d  + +  e  +p  d   ++   + +   +    +++g+f e +l++    ++ dt++ +  +++ g g+ +  +  + eD+++f
  EFC39948.1 109 ANVKYYIPSDFSIDFTKLDNTE-MLPRIDVRKKVHALLNQNtQLKWISILCGIFIEKLLQVS---FIVDTKKHA--LNFYGTGDEEFEIS-NYEDVAKF 200
                 *************999998877.8998888888888888777999999********999943...567888877..77777777545555.99****** PP

                 HHHHHHH..HHHHTTEEEEE-SEEE-HHHHHHHHHHHHT CS
        NmrA 190 vikilkd..prklkgkriklagntlsgneivelfekkig 226
                 v +++ +   +k++ + +++ ++ +++n+    ++ + g
  EFC39948.1 201 VSELIARkeFTKFEYQFVPIYSDRITMNKFGGWLKDVWG 239
                 ***998833455677788888899999886655555555 PP

>> Sacchrp_dh_NADP  Saccharopine dehydrogenase NADP binding domain
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   21.9   0.0   6.6e-08   0.00017       1      96 [.      10     113 ..      10     144 .. 0.86

  Alignments for each domain:
  == domain 1  score: 21.9 bits;  conditional E-value: 6.6e-08
                      EEEE--.SHHHHHHHHHHHCTCCT-G..EEEEEESSHHHHHHHHCHHTTTCEEEEE--TTTHHHHHHHHHTTSSEEEE-SSGG.......GHHH CS
  Sacchrp_dh_NADP   1 vliiGa.GsvGqavaellarhfdvda..eitvadrskeklealaakalgvrfeaialdaenyeavLaallkegdlvvnlsppi.......ssld 84 
                      vli+Ga G  G  +++ l ++++ d    + v + s++kl ++ +k+l+ ++ +  + ++  e+  + +lk+ +lv+n++  +           
       EFC39948.1  10 VLILGAsGHLGCQIVKNLCENHQKDVkcSLLVPSESRDKL-NVWEKKLNGKIFCFDVLKDSCED-FVNILKDFTLVLNCMNFFdheeelkAETR 101
                      89*********8888777666666556999*********6.55567799999999*********.******************77776655668 PP

                      HHHHHHHHT-EE CS
  Sacchrp_dh_NADP  85 vlkaCietgvhy 96 
                      v++ Ci++ v y
       EFC39948.1 102 VIESCIKANVKY 113
                      999999999998 PP

>> NAD_binding_10  NAD(P)H-binding
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   19.1   0.0   3.8e-07   0.00096       1     182 [.      14     206 ..      14     208 .. 0.72

  Alignments for each domain:
  == domain 1  score: 19.1 bits;  conditional E-value: 3.8e-07
                     TTTSHHHHHHHHHHHHC-..T-EEEEEETT..HHHCHHHHCTTTCEEEE--TT-C..CHHHHHHTT-SEEEES---TCCHHHH..HHHHHHHHHH CS
  NAD_binding_10   1 GAtGkvGrllvkellarg..ghevtalvRn..peklaeleaeeglevvegdvtdv..edlaealkgadaVvsalggggkdeeg..aknivdaake 87 
                     GA+G+ G ++vk l +++  +++  +lv +   +kl+  e++ + +++  dv++   ed  + lk+   V+ +++  + +ee     ++++ + +
      EFC39948.1  14 GASGHLGCQIVKNLCENHqkDVKCSLLVPSesRDKLNVWEKKLNGKIFCFDVLKDscEDFVNILKDFTLVLNCMNFFDHEEELkaETRVIESCIK 108
                     9****************97778888888762256777778889999*****9864459****************88777555555999******* PP

                     CT--EEEEEEETTTTSGCGCHHHHHHH.HCCHHHHHHHHHHHHHH.HHSSSEEEEEEE-CEE-ST.--SEEEEETTSS--.......--EE.EHH CS
  NAD_binding_10  88 agvkRfvlvsaigvgdevpgefgewnk.ellkaylaakraaeell.rasgldwTivrpggLtdep.ttkyrvvekgepfk.......ggsi.sra 171
                     a+vk ++  s + ++      f ++++ e+l + ++  ++  +ll ++++l+w  +  g + ++  +  + v +k+  ++       + +i + +
      EFC39948.1 109 ANVKYYIP-SDFSID------FTKLDNtEMLPR-IDVRKKVHALLnQNTQLKWISILCGIFIEKLlQVSFIVDTKKHALNfygtgdeEFEIsNYE 195
                     ***88887.777787......444444055555.555555555551669*****99999988875455555554433322222221144774568 PP

                     HHHHHHHHHCT CS
  NAD_binding_10 172 dVAdvlvavld 182
                     dVA+++ ++++
      EFC39948.1 196 DVAKFVSELIA 206
                     99999988875 PP

>> DapB_N  Dihydrodipicolinate reductase, N-terminus
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   15.9   0.0   4.2e-06     0.011       2      83 ..       9      89 ..       8     103 .. 0.80
   2 ?    0.7   0.0      0.21   5.3e+02      67      93 ..     113     142 ..      93     146 .. 0.73

  Alignments for each domain:
  == domain 1  score: 15.9 bits;  conditional E-value: 4.2e-06
                EEEEETTTSHHHHHHHHHHHHSTTEEEEEEEETTCSTTTTTBHHHHSSSS.--S-BEBSSHHHHHHH.-SEEEE-S-HHHHHHH CS
      DapB_N  2 kvavvGasGrmGkevvkaveeaedlelvaavdrkeselegkdagellglg.klgvavtddleevlek.advliDFTtpeavlen 83
                +v+++GasG +G ++vk + e+ +  + + +  ++   e++d  ++ +++ + +++ +d l++ +e+ +++l DFT    +++ 
  EFC39948.1  9 NVLILGASGHLGCQIVKNLCENHQKDVKCSLLVPS---ESRDKLNVWEKKlNGKIFCFDVLKDSCEDfVNILKDFTLVLNCMNF 89
                799****************9976666666666665...45677777777767788899*********999******77666655 PP

  == domain 2  score: 0.7 bits;  conditional E-value: 0.21
                 H...-SEEEE-S-HHHHHHHHHHHHHTT-E CS
      DapB_N  67 k...advliDFTtpeavlenlklalekgvk 93 
                     +d  iDFT+ + +  + ++ ++k+v+
  EFC39948.1 113 YyipSDFSIDFTKLDNTEMLPRIDVRKKVH 142
                 24457899****999998888887777776 PP

>> 3Beta_HSD  3-beta hydroxysteroid dehydrogenase/isomerase family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   14.9   0.1   3.9e-06      0.01       1     111 [.      11     114 ..      11     123 .. 0.61

  Alignments for each domain:
  == domain 1  score: 14.9 bits;  conditional E-value: 3.9e-06
   3Beta_HSD   1 vvtGgaGFlGralvkeLvrleelkevrvlDlrespelleelskvnvkk...viegDvtdkd..kleealegvdvvihlaslvdvagkltedeimkvnvk 94 
                 +++G++G lG ++vk+L + ++ k+v+   l+ s++  ++l+  + k    + + Dv++ +  +  + l++  +v+      d              +k
  EFC39948.1  11 LILGASGHLGCQIVKNLCENHQ-KDVKCSLLVPSESR-DKLNVWEKKLngkIFCFDVLKDSceDFVNILKDFTLVLNCMNFFDHE----------EELK 97 
                 699***************9996.9**99877665554.44433333311225555555543113445555555544443333333..........3445 PP

   3Beta_HSD  95 GTrnvleacvkagvrvl 111
                     v+e+c+ka+v++ 
  EFC39948.1  98 AETRVIESCIKANVKYY 114
                 55678888888888775 PP

>> NAD_binding_4  Male sterility protein
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?    9.7   0.0   0.00017      0.43       3      35 ..      14      47 ..      12      68 .. 0.86
   2 ?   -2.8   0.0       1.1   2.8e+03     178     216 ..     197     235 ..     184     249 .. 0.75

  Alignments for each domain:
  == domain 1  score: 9.7 bits;  conditional E-value: 0.00017
                   -TTSHHHHHHHHHHHHHS-.T.EEEEEE-SSSHH CS
  NAD_binding_4  3 GaTGFLGkvLlekLLrttpev.kiyllvRaksge 35
                   Ga+G LG+ ++++L +++++  k+ llv ++s +
     EFC39948.1 14 GASGHLGCQIVKNLCENHQKDvKCSLLVPSESRD 47
                   9**************9998877*99999877664 PP

  == domain 2  score: -2.8 bits;  conditional E-value: 1.1
                    HHHHHHHHHHHHHHHHH---EEEEEE-EEE--SSST--- CS
  NAD_binding_4 178 qsKalaEklvrearrrsglpvvivRpsiitgesktGwin 216
                      K+++E + r+++ + ++++v +    it + + Gw++
     EFC39948.1 197 VAKFVSELIARKEFTKFEYQFVPIYSDRITMNKFGGWLK 235
                    578999999999887777777777777777777777765 PP

>> Pox_A_type_inc  Viral A-type inclusion protein repeat
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -0.0   0.0      0.36   9.1e+02       8      13 ..       3       8 ..       3       9 .. 0.89
   2 ?    9.2   0.7   0.00044       1.1      10      21 ..     251     262 ..     247     264 .. 0.89

  Alignments for each domain:
  == domain 1  score: -0.0 bits;  conditional E-value: 0.36
  Pox_A_type_inc  8 sRIsDL 13
                    s+IsDL
      EFC39948.1  3 SKISDL 8 
                    79***9 PP

  == domain 2  score: 9.2 bits;  conditional E-value: 0.00044
  Pox_A_type_inc  10 IsDLErqLseCr 21 
                     IsDL+++L eC 
      EFC39948.1 251 ISDLDKKLRECE 262
                     9**********5 PP



Internal pipeline statistics summary:
-------------------------------------
Query sequence(s):                         1  (315 residues searched)
Target model(s):                       17929  (3037991 nodes)
Passed MSV filter:                       842  (0.046963); expected 358.6 (0.02)
Passed bias filter:                      524  (0.0292264); expected 358.6 (0.02)
Passed Vit filter:                        57  (0.00317921); expected 17.9 (0.001)
Passed Fwd filter:                         7  (0.000390429); expected 0.2 (1e-05)
Initial search space (Z):              17929  [actual number of targets]
Domain search space  (domZ):               7  [number of targets reported over threshold]
# CPU time: 0.65u 0.33s 00:00:00.98 Elapsed: 00:00:00.54
# Mc/sec: 1746.56
//
Query:       EFC39949.1  [L=387]
Description: rab family GTPase [Naegleria gruberi]
Scores for complete sequence (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Model         Description
    ------- ------ -----    ------- ------ -----   ---- --  --------      -----------
    2.3e-23   82.6   0.0    4.1e-23   81.8   0.0    1.4  1  Ras            Ras family
    2.6e-14   53.5   0.0    7.9e-14   51.9   0.0    1.9  1  Roc            Ras of Complex, Roc, domain of DAPkinase
    1.3e-08   34.5   0.0    2.5e-08   33.6   0.0    1.5  1  Arf            ADP-ribosylation factor family
    0.00046   20.0   0.0      0.001   18.9   0.0    1.5  1  F-box          F-box domain
  ------ inclusion threshold ------
       0.14   12.1   0.0       0.28   11.1   0.0    1.5  1  F-box-like     F-box-like
       0.38   10.2   1.8        4.6    6.6   1.8    2.2  1  Hist_deacetyl  Histone deacetylase domain


Domain annotation for each model (and alignments):
>> Ras  Ras family
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   81.8   0.0   1.4e-26   4.1e-23       2     146 ..     201     367 ..     200     376 .. 0.88

  Alignments for each domain:
  == domain 1  score: 81.8 bits;  conditional E-value: 1.4e-26
                 EEEEESTTSSHHHHHHHHHHSSCSSSCTTTSSEEEEEEEEEETTEEEEEEEEEETTSGGGHHHHHHHHTTESEEEEEEETTBHHHHHTHHHHHHHHHHH CS
         Ras   2 lvlvGdsavGKtslllrfvkdkFkeeyesTigvdfytkeievdgkevkleiwDTAGqeefkslrelyyrdaegillvyditsresfenvkkwveeikrv 100
                 + l+G   +GK+  l r  +++F++ y +Tigv+fy k ++ ++  +k+ iwDT G  +f++   +yyr+a++++ ++d+++++sfe++kk v ++ ++
  EFC39949.1 201 VTLLGPMKCGKSEYLKRLHQSEFSSIYRPTIGVEFYPKYFNDSQCMMKFLIWDTSGDPQFSHNSLSYYRGARVVFFCFDLSDSASFEDMKKQVVDLDQQ 299
                 5799*****************************************************************************************999999 PP

                 ST...........TTSEEEEEEETTTGGG...........G-SS-HHHHHHHHHHHTSEEEEEBTTTT CS
         Ras 101 ae...........envpivLvGnKvDlee...........kravsteegeelakelglkfletSAktn 146
                              +++ ++++G K Dl++            + v t +     ++ +l ++e+S k++
  EFC39949.1 300 FYifremkedtrkDSILFIILGMKRDLKRqvsqqviseyiAELVPTYNDAMKFSNAKLVYFEISSKED 367
                 88889999999998899***********8787666666665555544444344677799999999886 PP

>> Roc  Ras of Complex, Roc, domain of DAPkinase
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 !   51.9   0.0   2.7e-17   7.9e-14       2      97 ..     201     291 ..     200     326 .. 0.76

  Alignments for each domain:
  == domain 1  score: 51.9 bits;  conditional E-value: 2.7e-17
                 EEEESSTTSSHHHHHHCHCT-CCC-EEETTTTEEEEEEECGGSGGCTTBTTTTCEEEEEEEE-SGGCTTTT-HHHHCTSCEEEEEEE...GHHHHCHHH CS
         Roc   2 vvlvGdsgvGKtsllkrfvedkfsekekstigvdfltkevtkikgvendkkvkkvklniWDtaGqerfrslhplylreaalailvyd...srssenlke 97 
                 v l+G  + GK+  lkr+ +++fs+ +++tigv+f+ k ++       d++   +k+ iWDt+G  +f+    +y+r+a ++++++d   s s+e++k+
  EFC39949.1 201 VTLLGPMKCGKSEYLKRLHQSEFSSIYRPTIGVEFYPKYFN-------DSQ-CMMKFLIWDTSGDPQFSHNSLSYYRGARVVFFCFDlsdSASFEDMKK 291
                 789*********************************99763.......222.3589******************************9654334443332 PP

>> Arf  ADP-ribosylation factor family
   #    score  